term p.value Adjusted.p.value fold_change gene_coverage subcluster cluster subset_cluster decreased atrioventricular cushion size 0.000381315423762376 0.164354007169681 6.54500061899063 0.454545454545455 1.2 1 2 abnormal aerobic respiration 0.000700415696384751 0.231763982429525 4.79966712059313 0.333333333333333 1.2 1 2 liver vascular congestion 0.001990677089537 0.330120617348219 4.79966712059313 0.333333333333333 1.2 1 2 vasculature congestion 0.00274181294333245 0.349756907514845 4.49968792555606 0.3125 1.2 1 2 abnormal optic stalk morphology 0.00130697991646728 0.280025971871635 4.31970040853382 0.3 1.2 1 2 abnormal touch/ nociception 0.00367840678249935 0.397827690063789 4.23500040052335 0.294117647058824 1.2 1 2 abnormal heart shape 0.00482378796946651 0.413764571518895 3.99972260049428 0.277777777777778 1.2 1 2 increased effector memory CD8-positive, alpha-beta T cell number 0.00482378796946651 0.413764571518895 3.99972260049428 0.277777777777778 1.2 1 2 pulmonary vascular congestion 0.00224926997809457 0.339094489121834 3.92700037139438 0.272727272727273 1.2 1 2 short humerus 4.33133235276758e-05 0.0528004363317837 3.86314670681886 0.268292682926829 1.2 1 2 abnormal pain threshold 0.000502345869256281 0.192243899965384 3.83973369647451 0.266666666666667 1.2 1 2 abnormal dopamine level 0.00783228082964818 0.518158872725382 3.59975034044485 0.25 1.2 1 2 shortened head 0.00170050920568095 0.313334566602324 3.59975034044485 0.25 1.2 1 2 decreased oocyte number 6.52909894816774e-05 0.0528004363317837 3.45576032682705 0.24 1.2 1 2 abnormal nest building behavior 0.00451574969553075 0.413764571518895 3.45576032682705 0.24 1.2 1 2 abnormal vertebrae development 0.00451574969553075 0.413764571518895 3.45576032682705 0.24 1.2 1 2 abnormal hair cycle 0.00260886209735229 0.341554971955991 3.35976698441519 0.233333333333333 1.2 1 2 abnormal synaptic transmission 0.00260886209735229 0.341554971955991 3.35976698441519 0.233333333333333 1.2 1 2 cleft upper lip 0.0119421705806135 0.595962830367755 3.27250030949532 0.227272727272727 1.2 1 2 increased circulating creatine kinase level 0.0119421705806135 0.595962830367755 3.27250030949532 0.227272727272727 1.2 1 2 increased adenoma incidence 0.0119421705806135 0.595962830367755 3.27250030949532 0.227272727272727 1.2 1 2 abnormal nose morphology 0.00318345551087104 0.377087884918653 3.25138740427277 0.225806451612903 1.2 1 2 short ulna 0.00106061043158052 0.251263661767289 3.16075639648816 0.219512195121951 1.2 1 2 abnormal respiratory electron transport chain 0.00220829047680354 0.339094489121834 3.11329759173608 0.216216216216216 1.2 1 2 premature aging 0.00813152984003005 0.518645653258327 3.08550029180987 0.214285714285714 1.2 1 2 abnormal inner cell mass apoptosis 0.0173104549511504 0.678106404582466 2.99979195037071 0.208333333333333 1.2 1 2 abnormal truncus arteriosus septation 0.0173104549511504 0.678106404582466 2.99979195037071 0.208333333333333 1.2 1 2 short sternum 0.0097004484998301 0.561159666123892 2.97910373002332 0.206896551724138 1.2 1 2 increased B cell derived lymphoma incidence 0.00122395819854945 0.276781456262887 2.87980027235588 0.2 1.2 1 2 short radius 0.00761259856521203 0.518158872725382 2.79980582034599 0.194444444444444 1.2 1 2 small cranium 0.0134629186019484 0.637885905187553 2.78690348937666 0.193548387096774 1.2 1 2 pulmonary edema 0.0240701731635767 0.700287201688854 2.76903872341911 0.192307692307692 1.2 1 2 abnormal pancreas morphology 0.00506115020897774 0.419653704827738 2.74266692605322 0.19047619047619 1.2 1 2 abnormal hair follicle development 0.00887360378584068 0.525549748030445 2.72413539276907 0.189189189189189 1.2 1 2 osteoporosis 0.0067754681408699 0.50310379105713 2.61800024759625 0.181818181818182 1.2 1 2 increased cardiomyocyte apoptosis 0.0181401298496663 0.692214877656388 2.61800024759625 0.181818181818182 1.2 1 2 single kidney 0.0181401298496663 0.692214877656388 2.61800024759625 0.181818181818182 1.2 1 2 abnormal ovulation 0.0323262827483931 0.816361709001299 2.57125024317489 0.178571428571429 1.2 1 2 absent corpus callosum 0.0323262827483931 0.816361709001299 2.57125024317489 0.178571428571429 1.2 1 2 increased bone resorption 0.0323262827483931 0.816361709001299 2.57125024317489 0.178571428571429 1.2 1 2 abnormal mitotic spindle morphology 0.0323262827483931 0.816361709001299 2.57125024317489 0.178571428571429 1.2 1 2 increased susceptibility to weight gain 0.020850141336419 0.692214877656388 2.54100024031401 0.176470588235294 1.2 1 2 decreased brain weight 0.00340536199569716 0.385038089286213 2.52614058978586 0.175438596491228 1.2 1 2 abnormal locomotor behavior 0.000268388408054321 0.133523233007025 2.50417414987468 0.173913043478261 1.2 1 2 increased mortality induced by gamma-irradiation 0.0370399982168438 0.842726407892208 2.4825864416861 0.172413793103448 1.2 1 2 abnormal liver development 0.0238214230670568 0.697126939756516 2.4684002334479 0.171428571428571 1.2 1 2 impaired behavioral response to xenobiotic 0.0238214230670568 0.697126939756516 2.4684002334479 0.171428571428571 1.2 1 2 impaired adaptive thermogenesis 0.0238214230670568 0.697126939756516 2.4684002334479 0.171428571428571 1.2 1 2 Leydig cell hyperplasia 0.0154726504531838 0.678106404582466 2.45836608615746 0.170731707317073 1.2 1 2 muscular ventricular septal defect 0.00498505705021879 0.419653704827738 2.39983356029657 0.166666666666667 1.2 1 2 abnormal locomotor activation 0.000740592428412282 0.231763982429525 2.37346176293067 0.164835164835165 1.2 1 2 abnormal contextual conditioning behavior 0.00851409257581269 0.525549748030445 2.35620022283663 0.163636363636364 1.2 1 2 abnormal double-strand DNA break repair 0.0198268466682935 0.692214877656388 2.34402347749897 0.162790697674419 1.2 1 2 abnormal cranial ganglia morphology 0.0476707154243869 0.842726407892208 2.32241957448055 0.161290322580645 1.2 1 2 increased neuron apoptosis 0.00208571640157336 0.334723841865402 2.31095083584114 0.160493827160494 1.2 1 2 microcephaly 0.00470049815048082 0.413764571518895 2.29549297071845 0.159420289855072 1.2 1 2 embryonic lethality, incomplete penetrance 0.022296026389698 0.692214877656388 2.29075021664672 0.159090909090909 1.2 1 2 decreased birth body size 0.000396431776087672 0.164354007169681 2.27352653080727 0.157894736842105 1.2 1 2 impaired branching involved in ureteric bud morphogenesis 0.034390492423126 0.842726407892208 2.27352653080727 0.157894736842105 1.2 1 2 dehydration 0.00525677320404917 0.428728634264666 2.2627002139939 0.157142857142857 1.2 1 2 abnormal cued conditioning behavior 0.016321135903873 0.678106404582466 2.25866688027912 0.156862745098039 1.2 1 2 failure of chorioallantoic fusion 0.016321135903873 0.678106404582466 2.25866688027912 0.156862745098039 1.2 1 2 abnormal tooth morphology 0.00792396869363544 0.518158872725382 2.24984396277803 0.15625 1.2 1 2 abnormal long term potentiation 0.0535946750330421 0.842726407892208 2.24984396277803 0.15625 1.2 1 2 abnormal auditory brainstem response waveform shape 0.0535946750330421 0.842726407892208 2.24984396277803 0.15625 1.2 1 2 oxidative stress 0.00194361643612098 0.330120617348219 2.23984465627679 0.155555555555556 1.2 1 2 abnormal brain morphology 4.38379639936213e-05 0.0528004363317837 2.23586977667382 0.15527950310559 1.2 1 2 eyelids open at birth 0.0182227693165858 0.692214877656388 2.21523097873529 0.153846153846154 1.2 1 2 atrial septal defect 0.0278548690722231 0.768854994110583 2.19115238114034 0.152173913043478 1.2 1 2 reduced long term potentiation 0.000898649421066691 0.248376714989266 2.18556270669866 0.151785714285714 1.2 1 2 decreased brown adipose tissue amount 0.0599258438157877 0.842726407892208 2.18166687299688 0.151515151515152 1.2 1 2 dilated heart atrium 0.0599258438157877 0.842726407892208 2.18166687299688 0.151515151515152 1.2 1 2 increased osteoblast cell number 0.0599258438157877 0.842726407892208 2.18166687299688 0.151515151515152 1.2 1 2 abnormal coat/ hair morphology 0.0202778119371406 0.692214877656388 2.17343416781576 0.150943396226415 1.2 1 2 abnormal kidney development 0.0148311881687451 0.678106404582466 2.15985020426691 0.15 1.2 1 2 abnormal skin pigmentation 0.0428870852081271 0.842726407892208 2.15985020426691 0.15 1.2 1 2 abnormal femur morphology 0.0108888989671862 0.595962830367755 2.1491046808626 0.149253731343284 1.2 1 2 kidney cysts 0.0080197453668049 0.518158872725382 2.14039209431856 0.148648648648649 1.2 1 2 limb grasping 5.03601400414074e-05 0.0528004363317837 2.1361155866376 0.148351648351648 1.2 1 2 decreased heart weight 0.00592226265865757 0.460363386356585 2.13318538693028 0.148148148148148 1.2 1 2 axon degeneration 0.022492136036749 0.692214877656388 2.13318538693028 0.148148148148148 1.2 1 2 lung hemorrhage 0.0666630338984375 0.842726407892208 2.11750020026167 0.147058823529412 1.2 1 2 abnormal brown adipose tissue morphology 0.0666630338984375 0.842726407892208 2.11750020026167 0.147058823529412 1.2 1 2 abnormal osteoclast morphology 0.0342839845754439 0.842726407892208 2.09985436525949 0.145833333333333 1.2 1 2 abnormal joint morphology 0.0248713774769084 0.719390133416393 2.094400198077 0.145454545454545 1.2 1 2 perimembraneous ventricular septal defect 0.0132881369733518 0.635658475407937 2.08681179156223 0.144927536231884 1.2 1 2 abnormal nervous system electrophysiology 0.00791813704178408 0.518158872725382 2.05700019453991 0.142857142857143 1.2 1 2 absent kidney 0.0378390500710796 0.842726407892208 2.05700019453991 0.142857142857143 1.2 1 2 skin edema 0.0525919946101327 0.842726407892208 2.05700019453991 0.142857142857143 1.2 1 2 increased T cell derived lymphoma incidence 0.0378390500710796 0.842726407892208 2.05700019453991 0.142857142857143 1.2 1 2 abnormal reproductive system morphology 0.0525919946101327 0.842726407892208 2.05700019453991 0.142857142857143 1.2 1 2 abnormal artery morphology 0.0738033023703342 0.871438061180357 2.05700019453991 0.142857142857143 1.2 1 2 abnormal cornea morphology 0.0117959659710197 0.595962830367755 2.03062839717402 0.141025641025641 1.2 1 2 incomplete embryo turning 0.0301458193268025 0.808201246875771 2.02091247182869 0.140350877192982 1.2 1 2 abnormal facial morphology 0.0301458193268025 0.808201246875771 2.02091247182869 0.140350877192982 1.2 1 2 abnormal interventricular septum morphology 0.041627550935733 0.842726407892208 2.01586019064911 0.14 1.2 1 2 abnormal hindlimb morphology 0.041627550935733 0.842726407892208 2.01586019064911 0.14 1.2 1 2 increased body length 0.041627550935733 0.842726407892208 2.01586019064911 0.14 1.2 1 2 increased oxygen consumption 0.00951722236663024 0.55703742675277 2.0091629807134 0.13953488372093 1.2 1 2 decreased oxygen consumption 0.0579052618439445 0.842726407892208 2.0091629807134 0.13953488372093 1.2 1 2 heart right ventricle hypertrophy 0.0813420304998356 0.930291038475131 1.99986130024714 0.138888888888889 1.2 1 2 reduced long term depression 0.0813420304998356 0.930291038475131 1.99986130024714 0.138888888888889 1.2 1 2 abnormal lysosome morphology 0.0813420304998356 0.930291038475131 1.99986130024714 0.138888888888889 1.2 1 2 abnormal response to novel object 0.0456535715089835 0.842726407892208 1.97633352024423 0.137254901960784 1.2 1 2 increased kidney weight 0.0456535715089835 0.842726407892208 1.97633352024423 0.137254901960784 1.2 1 2 astrocytosis 0.0192461563697788 0.692214877656388 1.97246593996978 0.136986301369863 1.2 1 2 reduced fertility 0.00167677774782072 0.313334566602324 1.96820881923603 0.136690647482014 1.2 1 2 abnormal astrocyte morphology 0.0635277727051413 0.842726407892208 1.96350018569719 0.136363636363636 1.2 1 2 increased erythroid progenitor cell number 0.0892730114142267 0.96396048807612 1.94581099483505 0.135135135135135 1.2 1 2 abnormal humerus morphology 0.0892730114142267 0.96396048807612 1.94581099483505 0.135135135135135 1.2 1 2 distended pericardium 0.0499205851833563 0.842726407892208 1.93832710639338 0.134615384615385 1.2 1 2 abnormal hair growth 0.0499205851833563 0.842726407892208 1.93832710639338 0.134615384615385 1.2 1 2 abnormal neurocranium morphology 0.0228679112343011 0.692214877656388 1.91986684823725 0.133333333333333 1.2 1 2 abnormal cell migration 0.0694597744239324 0.842726407892208 1.91986684823725 0.133333333333333 1.2 1 2 abnormal heart development 0.00141457869065414 0.281501159440174 1.9137913202365 0.132911392405063 1.2 1 2 polydactyly 0.0108000513777357 0.595962830367755 1.91007160921563 0.13265306122449 1.2 1 2 decreased grip strength 0.000211968191511866 0.117171305863504 1.90671707530412 0.132420091324201 1.2 1 2 ventricular septal defect 0.00312709797095047 0.377087884918653 1.90575018023551 0.132352941176471 1.2 1 2 pericardial edema 0.0312489669318515 0.808201246875771 1.90575018023551 0.132352941176471 1.2 1 2 decreased hair follicle number 0.0975885445946966 0.982978901917165 1.89460544233939 0.131578947368421 1.2 1 2 incomplete somite formation 0.0975885445946966 0.982978901917165 1.89460544233939 0.131578947368421 1.2 1 2 hyporesponsive to tactile stimuli 0.0975885445946966 0.982978901917165 1.89460544233939 0.131578947368421 1.2 1 2 abnormal kidney morphology 0.00100742017285972 0.250595767998856 1.89244017897672 0.131428571428571 1.2 1 2 abnormal maternal nurturing 0.042889703152226 0.842726407892208 1.88839362121697 0.131147540983607 1.2 1 2 decreased spleen weight 0.0339430914256264 0.842726407892208 1.87813061240601 0.130434782608696 1.2 1 2 abnormal forelimb morphology 0.0757005102266888 0.884061122952527 1.87813061240601 0.130434782608696 1.2 1 2 abnormal vitelline vasculature morphology 0.00756334838146175 0.518158872725382 1.87813061240601 0.130434782608696 1.2 1 2 abnormal nervous system physiology 0.00756334838146175 0.518158872725382 1.87813061240601 0.130434782608696 1.2 1 2 impaired limb coordination 0.0591883598883874 0.842726407892208 1.866537213564 0.12962962962963 1.2 1 2 abnormal apoptosis 0.0591883598883874 0.842726407892208 1.866537213564 0.12962962962963 1.2 1 2 decreased startle reflex 0.00883393540823341 0.525549748030445 1.84602581561274 0.128205128205128 1.2 1 2 absent gastric milk in neonates 0.0291880193353004 0.793499432749286 1.84602581561274 0.128205128205128 1.2 1 2 abnormal iris morphology 0.106279535656478 0.982978901917165 1.84602581561274 0.128205128205128 1.2 1 2 increased circulating creatinine level 0.0232276245073612 0.692214877656388 1.84173273232062 0.127906976744186 1.2 1 2 abnormal tibia morphology 0.0822482421489001 0.936350125150522 1.83817038661013 0.127659574468085 1.2 1 2 abnormal cell nucleus morphology 0.0822482421489001 0.936350125150522 1.83817038661013 0.127659574468085 1.2 1 2 decreased liver weight 0.0398022161355774 0.842726407892208 1.8252255247326 0.126760563380282 1.2 1 2 embryonic lethality, complete penetrance 5.32089673539954e-05 0.0528004363317837 1.80551741213535 0.125391849529781 1.2 1 2 abnormal digit morphology 0.0429737096509358 0.842726407892208 1.79987517022242 0.125 1.2 1 2 hydrops fetalis 0.0429737096509358 0.842726407892208 1.79987517022242 0.125 1.2 1 2 impaired ovarian folliculogenesis 0.115335600006242 0.982978901917165 1.79987517022242 0.125 1.2 1 2 short mandible 0.0694460641261928 0.842726407892208 1.79987517022242 0.125 1.2 1 2 perinatal lethality, incomplete penetrance 0.000791957326894859 0.231763982429525 1.7839470713709 0.123893805309735 1.2 1 2 increased bone trabecula number 0.12474516909118 0.982978901917165 1.75597577582676 0.121951219512195 1.2 1 2 hydroencephaly 0.0170727718320484 0.678106404582466 1.75292190491227 0.121739130434783 1.2 1 2 impaired coordination 7.42920712206001e-05 0.0528004363317837 1.74785565663218 0.121387283236994 1.2 1 2 abnormal neuron morphology 0.0267413188238521 0.747404837913845 1.7453334983975 0.121212121212121 1.2 1 2 pale yolk sac 0.0423108186962402 0.842726407892208 1.73481944117824 0.120481927710843 1.2 1 2 kyphosis 0.00870955378746082 0.525549748030445 1.72788016341353 0.12 1.2 1 2 short stride length 0.103701934594489 0.982978901917165 1.72788016341353 0.12 1.2 1 2 abnormal digestive system physiology 0.103701934594489 0.982978901917165 1.72788016341353 0.12 1.2 1 2 abnormal circulating protein level 0.103701934594489 0.982978901917165 1.72788016341353 0.12 1.2 1 2 abnormal cytotoxic T cell physiology 0.134495598075106 1 1.71416682878326 0.119047619047619 1.2 1 2 ataxia 0.0031370643940606 0.377087884918653 1.71077243902329 0.118811881188119 1.2 1 2 syndactyly 0.0866969087741557 0.96396048807612 1.70835609377044 0.11864406779661 1.2 1 2 hyperactivity 8.75957922488845e-05 0.054473633304775 1.70769827471238 0.118598382749326 1.2 1 2 abnormal axial skeleton morphology 0.0573361866828116 0.842726407892208 1.70514489810545 0.118421052631579 1.2 1 2 abnormal cervical vertebrae morphology 0.111441716339223 0.982978901917165 1.69400016020934 0.117647058823529 1.2 1 2 abnormal blood vessel morphology 0.0131580257377767 0.635545417916883 1.68815878034655 0.117241379310345 1.2 1 2 increased erythrocyte cell number 0.0929411725515617 0.968436157929962 1.6798834922076 0.116666666666667 1.2 1 2 reduced female fertility 0.00243179529686835 0.341554971955991 1.67574584813812 0.116379310344828 1.2 1 2 abnormal organ of Corti morphology 0.144573273894995 1 1.67430248392784 0.116279069767442 1.2 1 2 abnormal intestinal mucosa morphology 0.144573273894995 1 1.67430248392784 0.116279069767442 1.2 1 2 respiratory distress 0.00885590971946037 0.525549748030445 1.66462443488779 0.115606936416185 1.2 1 2 abnormal excitatory postsynaptic currents 0.0655527205057901 0.842726407892208 1.66142323405147 0.115384615384615 1.2 1 2 abnormal heart ventricle morphology 0.0655527205057901 0.842726407892208 1.66142323405147 0.115384615384615 1.2 1 2 decreased kidney weight 0.119466211707379 0.982978901917165 1.66142323405147 0.115384615384615 1.2 1 2 abnormal brain wave pattern 0.119466211707379 0.982978901917165 1.66142323405147 0.115384615384615 1.2 1 2 increased percent body fat/body weight 0.119466211707379 0.982978901917165 1.66142323405147 0.115384615384615 1.2 1 2 prenatal lethality, incomplete penetrance 0.000751369518911175 0.231763982429525 1.65777976204697 0.115131578947368 1.2 1 2 abnormal long bone morphology 0.0994293259922163 0.982978901917165 1.65234441856485 0.114754098360656 1.2 1 2 increased osteoclast cell number 0.0994293259922163 0.982978901917165 1.65234441856485 0.114754098360656 1.2 1 2 cleft palate 0.0230840926967215 0.692214877656388 1.64874061394421 0.114503816793893 1.2 1 2 abnormal erythropoiesis 0.0397461003309315 0.842726407892208 1.64560015563193 0.114285714285714 1.2 1 2 domed cranium 0.0832041084545608 0.940773726276 1.64560015563193 0.114285714285714 1.2 1 2 abnormal action potential 0.0832041084545608 0.940773726276 1.64560015563193 0.114285714285714 1.2 1 2 embryonic lethality between somite formation and embryo turning, complete penetrance 0.0832041084545608 0.940773726276 1.64560015563193 0.114285714285714 1.2 1 2 hunched posture 0.0699251045364143 0.842726407892208 1.64039256020272 0.113924050632911 1.2 1 2 abnormal nervous system morphology 0.0699251045364143 0.842726407892208 1.64039256020272 0.113924050632911 1.2 1 2 decreased anxiety-related response 0.0287708935580797 0.786457117865089 1.63891072410497 0.113821138211382 1.2 1 2 renal interstitial fibrosis 0.154963722765489 1 1.63625015474766 0.113636363636364 1.2 1 2 abnormal photoreceptor outer segment morphology 0.154963722765489 1 1.63625015474766 0.113636363636364 1.2 1 2 decreased macrophage cell number 0.154963722765489 1 1.63625015474766 0.113636363636364 1.2 1 2 cochlear hair cell degeneration 0.154963722765489 1 1.63625015474766 0.113636363636364 1.2 1 2 embryonic growth arrest 0.00403547326479693 0.404394182866274 1.6348211153112 0.11353711790393 1.2 1 2 decreased body length 0.00191741274524395 0.330120617348219 1.62908409567577 0.113138686131387 1.2 1 2 abnormal cell cycle 0.0359179306336675 0.842726407892208 1.62771319741854 0.11304347826087 1.2 1 2 corneal opacity 0.0887154598601459 0.96396048807612 1.6224226886512 0.112676056338028 1.2 1 2 abnormal posture 0.0744747751887915 0.875914909135314 1.61988765320018 0.1125 1.2 1 2 prenatal lethality, complete penetrance 0.00240128660659821 0.341554971955991 1.60564403674518 0.111510791366906 1.2 1 2 short snout 0.0476816796085863 0.842726407892208 1.59988904019771 0.111111111111111 1.2 1 2 gliosis 0.113125755403547 0.982978901917165 1.59988904019771 0.111111111111111 1.2 1 2 abnormal maxilla morphology 0.136341043092165 1 1.59988904019771 0.111111111111111 1.2 1 2 trabecula carnea hypoplasia 0.165651716308184 1 1.59988904019771 0.111111111111111 1.2 1 2 abnormal ovarian follicle morphology 0.165651716308184 1 1.59988904019771 0.111111111111111 1.2 1 2 thrombocytopenia 0.0264538139419534 0.743546465317616 1.58885532267911 0.110344827586207 1.2 1 2 increased blood urea nitrogen level 0.0264538139419534 0.743546465317616 1.58885532267911 0.110344827586207 1.2 1 2 abnormal vertebrae morphology 0.0505520671755582 0.842726407892208 1.58521115909498 0.110091743119266 1.2 1 2 increased thermal nociceptive threshold 0.070765708639015 0.842726407892208 1.58230784195378 0.10989010989011 1.2 1 2 abnormal excitatory postsynaptic potential 0.0841077470681618 0.94883456159661 1.58037819824408 0.109756097560976 1.2 1 2 abnormal learning/memory/conditioning 0.145175507165892 1 1.57080014855775 0.109090909090909 1.2 1 2 small testis 0.00406426314438466 0.404394182866274 1.56510884367167 0.108695652173913 1.2 1 2 embryonic lethality between implantation and placentation, complete penetrance 0.176621375586415 1 1.56510884367167 0.108695652173913 1.2 1 2 abnormal neural tube closure 0.0891911572755577 0.96396048807612 1.56133749706042 0.108433734939759 1.2 1 2 abnormal heart morphology 0.00862101702392245 0.525549748030445 1.55833348071206 0.108225108225108 1.2 1 2 small seminiferous tubules 0.106482177512276 0.982978901917165 1.55664879586804 0.108108108108108 1.2 1 2 increased anxiety-related response 0.0366628830187324 0.842726407892208 1.55384906781792 0.107913669064748 1.2 1 2 kinked tail 0.0669693069804509 0.842726407892208 1.5528334801919 0.107843137254902 1.2 1 2 abnormal eye development 0.154263040330656 1 1.54275014590493 0.107142857142857 1.2 1 2 delayed bone ossification 0.112809666174481 0.982978901917165 1.5358934785898 0.106666666666667 1.2 1 2 abnormal limb morphology 0.112809666174481 0.982978901917165 1.5358934785898 0.106666666666667 1.2 1 2 decreased hemoglobin content 0.0408084133104679 0.842726407892208 1.53180865550845 0.106382978723404 1.2 1 2 hepatic necrosis 0.187856272424214 1 1.53180865550845 0.106382978723404 1.2 1 2 abnormal tail morphology 0.13541300192395 1 1.52716681109781 0.106060606060606 1.2 1 2 abnormal cardiovascular system physiology 0.0505503814731253 0.842726407892208 1.51568435387152 0.105263157894737 1.2 1 2 abnormal circulating amino acid level 0.163594209969779 1 1.51568435387152 0.105263157894737 1.2 1 2 impaired glucose tolerance 0.0111056649677553 0.595962830367755 1.50957272341236 0.104838709677419 1.2 1 2 abnormal glucose homeostasis 0.0279683816237745 0.768854994110583 1.50319244985609 0.104395604395604 1.2 1 2 embryonic lethality during organogenesis, incomplete penetrance 0.0150275672443782 0.678106404582466 1.50250448992481 0.104347826086957 1.2 1 2 increased susceptibility to pharmacologically induced seizures 0.0935197153799831 0.968436157929962 1.49989597518535 0.104166666666667 1.2 1 2 abnormal cardiovascular system morphology 0.199339527479924 1 1.49989597518535 0.104166666666667 1.2 1 2 small heart 0.199339527479924 1 1.49989597518535 0.104166666666667 1.2 1 2 vertebral transformation 0.199339527479924 1 1.49989597518535 0.104166666666667 1.2 1 2 abnormal phalanx morphology 0.199339527479924 1 1.49989597518535 0.104166666666667 1.2 1 2 enlarged heart 0.016541929747067 0.678106404582466 1.48955186501166 0.103448275862069 1.2 1 2 perinatal lethality, complete penetrance 0.0213819822566375 0.692214877656388 1.48722079793027 0.103286384976526 1.2 1 2 abnormal myocardial fiber morphology 0.0985366578127471 0.982978901917165 1.48443313008035 0.103092783505155 1.2 1 2 decreased mean corpuscular hemoglobin 0.1513761542269 1 1.48225014018317 0.102941176470588 1.2 1 2 double outlet right ventricle 0.0874530178020925 0.96396048807612 1.4802711680334 0.102803738317757 1.2 1 2 increased body weight 0.0201815518447175 0.692214877656388 1.47846888982556 0.102678571428571 1.2 1 2 abnormal suckling behavior 0.117251890170661 0.982978901917165 1.47262513927289 0.102272727272727 1.2 1 2 hyperglycemia 0.117251890170661 0.982978901917165 1.47262513927289 0.102272727272727 1.2 1 2 short femur 0.117251890170661 0.982978901917165 1.47262513927289 0.102272727272727 1.2 1 2 organ of Corti degeneration 0.211053904630434 1 1.4692858532428 0.102040816326531 1.2 1 2 decreased urine osmolality 0.211053904630434 1 1.4692858532428 0.102040816326531 1.2 1 2 decreased bone mineral density 0.0145716395222725 0.678106404582466 1.46155276980468 0.101503759398496 1.2 1 2 abnormal coat appearance 0.159671850456479 1 1.46076825409356 0.101449275362319 1.2 1 2 abnormal placenta morphology 0.140077087784572 1 1.45812672018019 0.10126582278481 1.2 1 2 abnormal visceral yolk sac morphology 0.140077087784572 1 1.45812672018019 0.10126582278481 1.2 1 2 increased heart weight 0.0680397036845497 0.842726407892208 1.45025912996339 0.100719424460432 1.2 1 2 decreased insulin secretion 0.129683915398177 1 1.43990013617794 0.1 1.2 1 2 impaired fertilization 0.16816826623447 1 1.43990013617794 0.1 1.2 1 2 abnormal axon extension 0.222981901301094 1 1.43990013617794 0.1 1.2 1 2 respiratory failure 0.0665886650337562 0.842726407892208 1.43036437368669 0.0993377483443709 1.2 1 2 cataract 0.0943176075000878 0.968436157929962 1.4280001350525 0.0991735537190083 1.2 1 2 abnormal bone mineralization 0.0943176075000878 0.968436157929962 1.4280001350525 0.0991735537190083 1.2 1 2 increased grip strength 0.136150547847354 1 1.4240770577584 0.0989010989010989 1.2 1 2 abnormal neural tube morphology 0.0621907514598502 0.842726407892208 1.42212359128685 0.0987654320987654 1.2 1 2 neonatal lethality, complete penetrance 0.00355969404694281 0.393543952967567 1.42095408175455 0.0986842105263158 1.2 1 2 increased circulating free fatty acid level 0.176858416931662 1 1.4196198525698 0.0985915492957746 1.2 1 2 abnormal skeletal muscle fiber morphology 0.176858416931662 1 1.4196198525698 0.0985915492957746 1.2 1 2 abnormal spatial learning 0.0649958790268644 0.842726407892208 1.41339890667773 0.098159509202454 1.2 1 2 impaired balance 0.125920621436886 0.983445983749621 1.41166680017445 0.0980392156862745 1.2 1 2 increased lung adenocarcinoma incidence 0.235105834449124 1 1.41166680017445 0.0980392156862745 1.2 1 2 cochlear inner hair cell degeneration 0.235105834449124 1 1.41166680017445 0.0980392156862745 1.2 1 2 increased bone mineral density 0.116576387626893 0.982978901917165 1.40167269893428 0.0973451327433628 1.2 1 2 abnormal cranium morphology 0.0959351237444617 0.980035401701637 1.39691804256069 0.0970149253731343 1.2 1 2 decreased body weight 7.42135229450567e-06 0.0369212276651657 1.39570287836311 0.0969305331179321 1.2 1 2 increased tumor incidence 0.108026932837802 0.982978901917165 1.39345174468833 0.0967741935483871 1.2 1 2 pericardial effusion 0.213541878295052 1 1.39345174468833 0.0967741935483871 1.2 1 2 abnormal cell morphology 0.121907128138127 0.982978901917165 1.38937732438222 0.0964912280701754 1.2 1 2 postnatal lethality 0.0739189671996203 0.871438061180357 1.38785555294259 0.0963855421686747 1.2 1 2 abnormal lipid level 0.170300336775494 1 1.38785555294259 0.0963855421686747 1.2 1 2 absent corpus luteum 0.247407921974841 1 1.38451936170956 0.0961538461538462 1.2 1 2 kinked neural tube 0.247407921974841 1 1.38451936170956 0.0961538461538462 1.2 1 2 cleft secondary palate 0.156519361224479 1 1.3786277899576 0.0957446808510638 1.2 1 2 abnormal skeleton morphology 0.127371601068644 0.988570538715292 1.37729578243107 0.0956521739130435 1.2 1 2 arrest of spermatogenesis 0.178284364541424 1 1.37133346302661 0.0952380952380952 1.2 1 2 decreased exploration in new environment 0.178284364541424 1 1.37133346302661 0.0952380952380952 1.2 1 2 abnormal humoral immune response 0.144141194956983 1 1.37133346302661 0.0952380952380952 1.2 1 2 postnatal lethality, incomplete penetrance 0.0033670224060849 0.385038089286213 1.36891914354945 0.0950704225352113 1.2 1 2 decreased leukocyte cell number 0.109041146054038 0.982978901917165 1.36632859637323 0.0948905109489051 1.2 1 2 impaired righting response 0.163621138719926 1 1.36411591848436 0.0947368421052632 1.2 1 2 abnormal intestine morphology 0.204016554204282 1 1.36206769638454 0.0945945945945946 1.2 1 2 abnormal mesoderm development 0.259870359395535 1 1.35839635488485 0.0943396226415094 1.2 1 2 abnormal pancreatic islet morphology 0.259870359395535 1 1.35839635488485 0.0943396226415094 1.2 1 2 cyanosis 0.0751662431061253 0.88196240437022 1.34990637766682 0.09375 1.2 1 2 decreased circulating LDL cholesterol level 0.234848389408475 1 1.34990637766682 0.09375 1.2 1 2 decreased body size 0.00135087906028527 0.280025971871635 1.33524574031538 0.0927318295739348 1.2 1 2 abnormal chondrocyte morphology 0.272475391671388 1 1.33324086683143 0.0925925925925926 1.2 1 2 increased cell proliferation 0.272475391671388 1 1.33324086683143 0.0925925925925926 1.2 1 2 abnormal trabecular bone morphology 0.150537557791893 1 1.33100012587877 0.092436974789916 1.2 1 2 decreased monocyte cell number 0.245738980859888 1 1.32913858724117 0.0923076923076923 1.2 1 2 decreased embryo size 0.0128452423343891 0.626520398172412 1.32543108769517 0.0920502092050209 1.2 1 2 abnormal spleen morphology 0.101525691128317 0.982978901917165 1.32404610223259 0.0919540229885057 1.2 1 2 short limbs 0.203178799114266 1 1.32404610223259 0.0919540229885057 1.2 1 2 increased bone mineral content 0.170408428216232 1 1.32100929924582 0.0917431192660551 1.2 1 2 postnatal growth retardation 0.00630566304934171 0.475313237431439 1.31755568016282 0.0915032679738562 1.2 1 2 weight loss 0.105371503654159 0.982978901917165 1.31648012450554 0.0914285714285714 1.2 1 2 increased circulating calcium level 0.285205380121938 1 1.30900012379813 0.0909090909090909 1.2 1 2 abnormal skin morphology 0.256771578753482 1 1.30900012379813 0.0909090909090909 1.2 1 2 abnormal CNS synaptic transmission 0.193488872670772 1 1.30900012379813 0.0909090909090909 1.2 1 2 increased T cell number 0.211771490008626 1 1.30900012379813 0.0909090909090909 1.2 1 2 decreased circulating total protein level 0.285205380121938 1 1.30900012379813 0.0909090909090909 1.2 1 2 increased insulin sensitivity 0.138254397381627 1 1.30900012379813 0.0909090909090909 1.2 1 2 abnormal gait 0.0474737533035372 0.842726407892208 1.30476387744279 0.0906148867313916 1.2 1 2 abnormal hepatocyte morphology 0.184338150350508 1 1.29720732989004 0.0900900900900901 1.2 1 2 increased circulating alanine transaminase level 0.242463948581151 1 1.29221807092892 0.0897435897435897 1.2 1 2 abnormal seminal vesicle morphology 0.298042864415201 1 1.28562512158745 0.0892857142857143 1.2 1 2 abnormal pulmonary alveolus morphology 0.20923925893946 1 1.28307932926747 0.0891089108910891 1.2 1 2 abnormal seminiferous tubule morphology 0.154319344027032 1 1.28210286098036 0.089041095890411 1.2 1 2 decreased B cell proliferation 0.252418226714152 1 1.27586088015767 0.0886075949367089 1.2 1 2 abnormal myocardium layer morphology 0.252418226714152 1 1.27586088015767 0.0886075949367089 1.2 1 2 abnormal embryo size 0.1987641064711 1 1.27424790812207 0.0884955752212389 1.2 1 2 abnormal extraembryonic tissue morphology 0.217302352891322 1 1.27050012015701 0.0882352941176471 1.2 1 2 decreased circulating alanine transaminase level 0.279213701586311 1 1.270500120157 0.0882352941176471 1.2 1 2 preweaning lethality, incomplete penetrance 0.0400570017906574 0.842726407892208 1.26739376289501 0.0880195599022005 1.2 1 2 embryonic lethality before implantation, complete penetrance 0.188996284369429 1 1.26711211983659 0.088 1.2 1 2 abnormal craniofacial bone morphology 0.310970619650338 1 1.26307029489293 0.087719298245614 1.2 1 2 increased hepatocellular carcinoma incidence 0.310970619650338 1 1.26307029489293 0.087719298245614 1.2 1 2 abnormal retinal pigment epithelium morphology 0.262491705503182 1 1.2599126191557 0.0875 1.2 1 2 male infertility 0.0279724128510584 0.768854994110583 1.25955479109005 0.0874751491053678 1.2 1 2 abnormal craniofacial morphology 0.225484108132455 1 1.25816516753412 0.087378640776699 1.2 1 2 premature death 0.00608695164511781 0.465885914376325 1.25426841130483 0.0871080139372822 1.2 1 2 decreased T cell number 0.163284103392557 1 1.25208707493734 0.0869565217391304 1.2 1 2 improved glucose tolerance 0.137486768239041 1 1.24889297525638 0.086734693877551 1.2 1 2 cachexia 0.233779399728043 1 1.2460674255386 0.0865384615384615 1.2 1 2 decreased bone mineral content 0.131409091454855 1 1.2460674255386 0.0865384615384615 1.2 1 2 increased circulating alkaline phosphatase level 0.16875249832177 1 1.244358142376 0.0864197530864197 1.2 1 2 abnormal eye morphology 0.192583613989939 1 1.24307925425434 0.0863309352517986 1.2 1 2 decreased circulating glucose level 0.0980589366441262 0.982978901917165 1.23862377305629 0.0860215053763441 1.2 1 2 hypoglycemia 0.256658795188041 1 1.23862377305629 0.0860215053763441 1.2 1 2 abnormal definitive hematopoiesis 0.256658795188041 1 1.23862377305629 0.0860215053763441 1.2 1 2 embryonic lethality during organogenesis, complete penetrance 0.0308474336969197 0.808201246875771 1.23420011672395 0.0857142857142857 1.2 1 2 pallor 0.166048402119099 1 1.23420011672395 0.0857142857142857 1.2 1 2 anemia 0.144123172406925 1 1.22835082707123 0.0853080568720379 1.2 1 2 neonatal lethality, incomplete penetrance 0.12371650926323 0.982978901917165 1.21837703830441 0.0846153846153846 1.2 1 2 abnormal ovary morphology 0.313635078421741 1 1.2168170164884 0.0845070422535211 1.2 1 2 alopecia 0.275385857131689 1 1.21254748309721 0.0842105263157895 1.2 1 2 lethality throughout fetal growth and development, complete penetrance 0.173406354666932 1 1.21254748309721 0.0842105263157895 1.2 1 2 decreased total body fat amount 0.100462942613832 0.982978901917165 1.20710191056833 0.0838323353293413 1.2 1 2 abnormal eating behavior 0.350127857054334 1 1.19991678014828 0.0833333333333333 1.2 1 2 intracranial hemorrhage 0.350127857054334 1 1.19991678014828 0.0833333333333333 1.2 1 2 abnormal long bone epiphyseal plate morphology 0.350127857054334 1 1.19991678014828 0.0833333333333333 1.2 1 2 abnormal forebrain development 0.325262360000466 1 1.19991678014828 0.0833333333333333 1.2 1 2 abnormal heart left ventricle morphology 0.325262360000466 1 1.19991678014828 0.0833333333333333 1.2 1 2 postnatal lethality, complete penetrance 0.0938952009189701 0.968436157929962 1.19369959475891 0.0829015544041451 1.2 1 2 decreased erythrocyte cell number 0.220813785334207 1 1.19227399810912 0.0828025477707006 1.2 1 2 increased circulating triglyceride level 0.233038107802027 1 1.19164149200933 0.0827586206896552 1.2 1 2 decreased B cell number 0.185195312627094 1 1.18826710267111 0.0825242718446602 1.2 1 2 abnormal lung development 0.314328716053502 1 1.18580011214654 0.0823529411764706 1.2 1 2 circling 0.314328716053502 1 1.18580011214654 0.0823529411764706 1.2 1 2 hypoactivity 0.105621669673411 0.982978901917165 1.18400276449645 0.0822281167108753 1.2 1 2 decreased hematocrit 0.240087549334117 1 1.18347956398187 0.0821917808219178 1.2 1 2 seminiferous tubule degeneration 0.336946422443904 1 1.18347956398187 0.0821917808219178 1.2 1 2 increased total body fat amount 0.253894354214474 1 1.18200757447443 0.082089552238806 1.2 1 2 increased double-negative T cell number 0.363250884430489 1 1.18024601326061 0.0819672131147541 1.2 1 2 decreased litter size 0.150733407821435 1 1.1785659477613 0.0818505338078292 1.2 1 2 embryonic lethality between implantation and somite formation, complete penetrance 0.173518936682576 1 1.17542868259424 0.0816326530612245 1.2 1 2 abnormal embryonic tissue morphology 0.24721687164393 1 1.17542868259424 0.0816326530612245 1.2 1 2 increased sensitivity to induced morbidity/mortality 0.216550075624839 1 1.17383163275375 0.0815217391304348 1.2 1 2 abnormal rib morphology 0.261552585504066 1 1.17325196281165 0.0814814814814815 1.2 1 2 decreased IgG level 0.294572640084122 1 1.16748659690103 0.0810810810810811 1.2 1 2 abnormal angiogenesis 0.348675528465047 1 1.16748659690103 0.0810810810810811 1.2 1 2 decreased cell proliferation 0.222543810603184 1 1.16748659690103 0.0810810810810811 1.2 1 2 deafness 0.313855707693923 1 1.16355566559833 0.0808080808080808 1.2 1 2 prenatal lethality 0.376383253389738 1 1.16120978724027 0.0806451612903226 1.2 1 2 increased eosinophil cell number 0.376383253389738 1 1.16120978724027 0.0806451612903226 1.2 1 2 abnormal retinal pigmentation 0.335579018509746 1 1.15854033945351 0.0804597701149425 1.2 1 2 abnormal coat/hair pigmentation 0.303579786177465 1 1.1570626094287 0.0803571428571429 1.2 1 2 decreased heart rate 0.323643176421793 1 1.15192010894235 0.08 1.2 1 2 increased or absent threshold for auditory brainstem response 0.183346655644426 1 1.14594128484749 0.0795847750865052 1.2 1 2 increased liver weight 0.346278434553052 1 1.14537510832336 0.0795454545454545 1.2 1 2 abnormal hair follicle morphology 0.389510085880736 1 1.14277788585551 0.0793650793650794 1.2 1 2 increased circulating aspartate transaminase level 0.389510085880736 1 1.14277788585551 0.0793650793650794 1.2 1 2 reduced male fertility 0.222656672518951 1 1.14177103309264 0.079295154185022 1.2 1 2 abnormal behavior 0.196738276367274 1 1.13948931639981 0.079136690647482 1.2 1 2 no abnormal phenotype detected 0.00995538747819591 0.569287962115226 1.13698166372552 0.0789625360230548 1.2 1 2 abnormal blood homeostasis 0.321778617270315 1 1.13676326540364 0.0789473684210526 1.2 1 2 anophthalmia 0.357015518622012 1 1.13250572508377 0.0786516853932584 1.2 1 2 increased startle reflex 0.357015518622012 1 1.13250572508377 0.0786516853932584 1.2 1 2 abnormal muscle physiology 0.357015518622012 1 1.13250572508377 0.0786516853932584 1.2 1 2 microphthalmia 0.291492389535349 1 1.12933344013956 0.0784313725490196 1.2 1 2 abnormal testis morphology 0.330958728667987 1 1.1268783674436 0.0782608695652174 1.2 1 2 lethality throughout fetal growth and development, incomplete penetrance 0.274277270231937 1 1.12617887745761 0.0782122905027933 1.2 1 2 abnormal lens morphology 0.319544663492089 1 1.12492198138901 0.078125 1.2 1 2 abnormal osteoclast physiology 0.402617009310589 1 1.12492198138901 0.078125 1.2 1 2 polyuria 0.384018865155308 1 1.12200010611268 0.0779220779220779 1.2 1 2 abnormal cytokine secretion 0.299090823719815 1 1.12200010611268 0.0779220779220779 1.2 1 2 abnormal bone structure 0.27285572484966 1 1.11909337008648 0.077720207253886 1.2 1 2 abnormal lipid homeostasis 0.336845282923721 1 1.10761548936765 0.0769230769230769 1.2 1 2 increased embryonic tissue cell apoptosis 0.395815108203154 1 1.10761548936765 0.0769230769230769 1.2 1 2 abnormal B cell differentiation 0.378567860833289 1 1.10761548936765 0.0769230769230769 1.2 1 2 spleen hypoplasia 0.373245346564252 1 1.09706677042129 0.0761904761904762 1.2 1 2 increased circulating HDL cholesterol level 0.373245346564252 1 1.09706677042129 0.0761904761904762 1.2 1 2 abnormal spermatogenesis 0.308934094889055 1 1.09557619057017 0.0760869565217391 1.2 1 2 abnormal response to infection 0.407601153257045 1 1.09359504013514 0.0759493670886076 1.2 1 2 impaired swimming 0.428716293069021 1 1.09083343649844 0.0757575757575758 1.2 1 2 abnormal lung morphology 0.368082613174484 1 1.08900010299172 0.0756302521008403 1.2 1 2 edema 0.326542981686216 1 1.08829661455309 0.0755813953488372 1.2 1 2 extramedullary hematopoiesis 0.38324990561276 1 1.08671708390788 0.0754716981132075 1.2 1 2 lethargy 0.400167804821678 1 1.08379580142426 0.0752688172043011 1.2 1 2 increased circulating insulin level 0.345684968552973 1 1.07992510213345 0.075 1.2 1 2 rib fusion 0.441682613639444 1 1.0745523404313 0.0746268656716418 1.2 1 2 internal hemorrhage 0.441682613639444 1 1.0745523404313 0.0746268656716418 1.2 1 2 decreased white adipose tissue amount 0.441682613639444 1 1.0745523404313 0.0746268656716418 1.2 1 2 abnormal skeleton development 0.431102100582259 1 1.06659269346514 0.0740740740740741 1.2 1 2 abnormal embryo development 0.389564468823215 1 1.05875010013084 0.0735294117647059 1.2 1 2 abnormal inhibitory postsynaptic currents 0.454576971738899 1 1.05875010013084 0.0735294117647059 1.2 1 2 sparse hair 0.442797530762814 1 1.05358546549605 0.0731707317073171 1.2 1 2 abnormal developmental patterning 0.442797530762814 1 1.05358546549605 0.0731707317073171 1.2 1 2 abnormal response/metabolism to endogenous compounds 0.442797530762814 1 1.05358546549605 0.0731707317073171 1.2 1 2 retinal degeneration 0.432514185139269 1 1.04992718262975 0.0729166666666667 1.2 1 2 abnormal epidermal layer morphology 0.467387778922474 1 1.04340589578112 0.072463768115942 1.2 1 2 thymus hypoplasia 0.407283891146431 1 1.04340589578112 0.072463768115942 1.2 1 2 hemorrhage 0.358334365027861 1 1.04162988574574 0.0723404255319149 1.2 1 2 preweaning lethality, complete penetrance 0.247621002228089 1 1.03127982726258 0.0716216216216216 1.2 1 2 female infertility 0.367507834908016 1 1.02850009726996 0.0714285714285714 1.2 1 2 decreased circulating cholesterol level 0.410202991765355 1 1.02287987815919 0.0710382513661202 1.2 1 2 abnormal motor coordination/ balance 0.464612141992738 1 1.01811120739854 0.0707070707070707 1.2 1 2 decreased circulating serum albumin level 0.464612141992738 1 1.01811120739854 0.0707070707070707 1.2 1 2 cardiac fibrosis 0.477553931787593 1 1.0164000961256 0.0705882352941176 1.2 1 2 decreased lymphocyte cell number 0.452444228799826 1 1.01242978325011 0.0703125 1.2 1 2 seizures 0.463181608776146 1 1.01045623591434 0.0701754385964912 1.2 1 2 abnormal enzyme/coenzyme activity 0.4422258258674 1 1.00884722916926 0.0700636942675159 1.2 1 2 cochlear outer hair cell degeneration 0.505211805785402 1 0.999930650123569 0.0694444444444444 1.2 1 2 increased susceptibility to bacterial infection induced morbidity/mortality 0.505211805785402 1 0.999930650123569 0.0694444444444444 1.2 1 2 azoospermia 0.459009084383764 1 0.996157326915555 0.0691823899371069 1.2 1 2 increased leukocyte cell number 0.469164864131151 1 0.993034576674441 0.0689655172413793 1.2 1 2 decreased percent body fat/body weight 0.517584260442865 1 0.98623296998489 0.0684931506849315 1.2 1 2 decreased neutrophil cell number 0.492705744876713 1 0.984547101660129 0.0683760683760684 1.2 1 2 abnormal motor capabilities/coordination/movement 0.489534146184827 1 0.981750092848595 0.0681818181818182 1.2 1 2 small kidney 0.511640280960568 1 0.981750092848595 0.0681818181818182 1.2 1 2 abnormal retina morphology 0.499174503406732 1 0.959933424118626 0.0666666666666667 1.2 1 2 abnormal eye electrophysiology 0.531306605729757 1 0.952000090035001 0.0661157024793388 1.2 1 2 enlarged spleen 0.505654685084823 1 0.949934117617391 0.0659722222222222 1.2 1 2 small ovary 0.544856063713358 1 0.949384705172267 0.0659340659340659 1.2 1 2 obese 0.56566920111548 1 0.935000088427233 0.0649350649350649 1.2 1 2 abnormal axon morphology 0.55760351006193 1 0.933268606781998 0.0648148148148148 1.2 1 2 increased rib number 0.577303043095776 1 0.923012907806371 0.0641025641025641 1.2 1 2 small liver 0.577303043095776 1 0.923012907806371 0.0641025641025641 1.2 1 2 increased sensitivity to xenobiotic induced morbidity/mortality 0.577304813882492 1 0.916300086658689 0.0636363636363636 1.2 1 2 abnormal somite development 0.588769387003798 1 0.91132920011262 0.0632911392405063 1.2 1 2 increased inflammatory response 0.587499185030258 1 0.909410612322909 0.0631578947368421 1.2 1 2 abnormal social investigation 0.600062893860318 1 0.899937585111212 0.0625 1.2 1 2 increased circulating cholesterol level 0.596171430124076 1 0.899937585111212 0.0625 1.2 1 2 abnormal neuron differentiation 0.596575303461178 1 0.899937585111212 0.0625 1.2 1 2 increased spleen weight 0.606039614606741 1 0.891973535685449 0.0619469026548673 1.2 1 2 cardiac hypertrophy 0.6180717578282 1 0.881571511945677 0.0612244897959184 1.2 1 2 insulin resistance 0.630822999927037 1 0.872666749198751 0.0606060606060606 1.2 1 2 increased mean corpuscular hemoglobin 0.627972378204682 1 0.872666749198751 0.0606060606060606 1.2 1 2 enlarged liver 0.637722357071335 1 0.863940081706763 0.06 1.2 1 2 hydronephrosis 0.643419337009177 1 0.85708341439163 0.0595238095238095 1.2 1 2 abnormal T cell differentiation 0.647318862250332 1 0.855386219511647 0.0594059405940594 1.2 1 2 lung inflammation 0.66397558374287 1 0.84700008010467 0.0588235294117647 1.2 1 2 decreased cardiac muscle contractility 0.675163796034013 1 0.830711617025734 0.0576923076923077 1.2 1 2 teratozoospermia 0.683709636184508 1 0.818125077373829 0.0568181818181818 1.2 1 2 increased circulating glucose level 0.702811801287601 1 0.816964616271171 0.0567375886524823 1.2 1 2 infertility 0.701554131669677 1 0.807420637109125 0.0560747663551402 1.2 1 2 increased T cell proliferation 0.701554131669677 1 0.807420637109125 0.0560747663551402 1.2 1 2 abnormal liver morphology 0.732325939263332 1 0.80441348389829 0.0558659217877095 1.2 1 2 thin ventricular wall 0.702662668708324 1 0.799944520098855 0.0555555555555556 1.2 1 2 abnormal renal glomerulus morphology 0.718323706728615 1 0.792605579547489 0.055045871559633 1.2 1 2 small spleen 0.711837471324311 1 0.79115392097689 0.0549450549450549 1.2 1 2 decreased birth weight 0.746522162322107 1 0.757842176935758 0.0526315789473684 1.2 1 2 increased B cell number 0.778766944177614 1 0.738410326245097 0.0512820512820513 1.2 1 2 increased monocyte cell number 0.785398513201621 1 0.71995006808897 0.05 1.2 1 2 decreased T cell proliferation 0.852727845903826 1 0.681033848192269 0.0472972972972973 1.2 1 2 decreased circulating HDL cholesterol level 0.845158084945041 1 0.674953188833409 0.046875 1.2 1 2 abnormal dendritic cell physiology 0.83183241061067 1 0.672850530924271 0.0467289719626168 1.2 1 2 liver inflammation 0.896206026087112 1 0.599958390074141 0.0416666666666667 1.2 1 2 increased neutrophil cell number 0.915082062422259 1 0.595820746004665 0.0413793103448276 1.2 1 2 abnormal immune system physiology 0.911152539473525 1 0.580604893620137 0.0403225806451613 1.2 1 2 absent popliteal lymph nodes 0.000224127456034543 0.00325082826172552 2.32099853157122 1 1.1 1 1 gastric polyps 0.00247377041640824 0.0218020336211967 2.32099853157122 1 1.1 1 1 sirenomelia 0.00247377041640824 0.0218020336211967 2.32099853157122 1 1.1 1 1 thyroid hypoplasia 0.00247377041640824 0.0218020336211967 2.32099853157122 1 1.1 1 1 abnormal response to vitamins 0.00247377041640824 0.0218020336211967 2.32099853157122 1 1.1 1 1 abnormal inner cell mass proliferation 0.00247377041640824 0.0218020336211967 2.32099853157122 1 1.1 1 1 corneal deposits 0.00247377041640824 0.0218020336211967 2.32099853157122 1 1.1 1 1 abnormal olfactory bulb granule cell layer morphology 0.00247377041640824 0.0218020336211967 2.32099853157122 1 1.1 1 1 absent cervical lymph nodes 0.000444694907678638 0.0054357669918949 2.06310980584108 0.888888888888889 1.1 1 1 abnormal cerebellar layer morphology 0.000444694907678638 0.0054357669918949 2.06310980584108 0.888888888888889 1.1 1 1 liver cysts 0.00132083014158636 0.0133288640048522 2.03087371512482 0.875 1.1 1 1 elevated level of mitotic sister chromatid exchange 0.00132083014158636 0.0133288640048522 2.03087371512482 0.875 1.1 1 1 binucleate 0.00132083014158636 0.0133288640048522 2.03087371512482 0.875 1.1 1 1 abnormal kidney epithelium morphology 0.00132083014158636 0.0133288640048522 2.03087371512482 0.875 1.1 1 1 abnormal thymus epithelium morphology 0.00132083014158636 0.0133288640048522 2.03087371512482 0.875 1.1 1 1 abnormal olfactory bulb glomerular layer morphology 0.00132083014158636 0.0133288640048522 2.03087371512482 0.875 1.1 1 1 abnormal heart echocardiography feature 0.00132083014158636 0.0133288640048522 2.03087371512482 0.875 1.1 1 1 increased cornea thickness 0.00132083014158636 0.0133288640048522 2.03087371512482 0.875 1.1 1 1 abnormal kidney blood vessel morphology 2.62808812374185e-05 0.000554014339644732 1.98942731277533 0.857142857142857 1.1 1 1 mammary gland hyperplasia 0.00386766404001543 0.02983198232415 1.98942731277533 0.857142857142857 1.1 1 1 abnormal lacrimal gland morphology 0.00386766404001543 0.02983198232415 1.98942731277533 0.857142857142857 1.1 1 1 abnormal gastrulation movements 0.00386766404001543 0.02983198232415 1.98942731277533 0.857142857142857 1.1 1 1 abnormal lymph node primary follicle morphology 0.00386766404001543 0.02983198232415 1.98942731277533 0.857142857142857 1.1 1 1 abnormal nephron morphology 0.00386766404001543 0.02983198232415 1.98942731277533 0.857142857142857 1.1 1 1 abnormal optic tract morphology 0.00386766404001543 0.02983198232415 1.98942731277533 0.857142857142857 1.1 1 1 heart hemorrhage 0.00386766404001543 0.02983198232415 1.98942731277533 0.857142857142857 1.1 1 1 abnormal T wave 0.00386766404001543 0.02983198232415 1.98942731277533 0.857142857142857 1.1 1 1 decreased collagen level 0.00386766404001543 0.02983198232415 1.98942731277533 0.857142857142857 1.1 1 1 thin tail 0.0111194590868618 0.0634395744921303 1.93416544297602 0.833333333333333 1.1 1 1 non-obstructive hydrocephaly 0.0111194590868618 0.0634395744921303 1.93416544297602 0.833333333333333 1.1 1 1 abnormal lymph node cortex morphology 0.0111194590868618 0.0634395744921303 1.93416544297602 0.833333333333333 1.1 1 1 abnormal cervical lymph node morphology 0.0111194590868618 0.0634395744921303 1.93416544297602 0.833333333333333 1.1 1 1 chromatolysis 0.0111194590868618 0.0634395744921303 1.93416544297602 0.833333333333333 1.1 1 1 decreased liver function 0.0111194590868618 0.0634395744921303 1.93416544297602 0.833333333333333 1.1 1 1 abnormal zona pellucida morphology 0.0111194590868618 0.0634395744921303 1.93416544297602 0.833333333333333 1.1 1 1 abnormal milk ejection 0.0111194590868618 0.0634395744921303 1.93416544297602 0.833333333333333 1.1 1 1 decreased prostate gland weight 0.0111194590868618 0.0634395744921303 1.93416544297602 0.833333333333333 1.1 1 1 decreased platelet ADP level 0.0111194590868618 0.0634395744921303 1.93416544297602 0.833333333333333 1.1 1 1 absent sperm mitochondrial sheath 0.0111194590868618 0.0634395744921303 1.93416544297602 0.833333333333333 1.1 1 1 increased erythrocyte clearance 0.0111194590868618 0.0634395744921303 1.93416544297602 0.833333333333333 1.1 1 1 enlarged lymphatic vessel 0.0111194590868618 0.0634395744921303 1.93416544297602 0.833333333333333 1.1 1 1 myocardium hypoplasia 0.0111194590868618 0.0634395744921303 1.93416544297602 0.833333333333333 1.1 1 1 persistent hyperplastic primary vitreous 0.0111194590868618 0.0634395744921303 1.93416544297602 0.833333333333333 1.1 1 1 abnormal kidney collecting duct epithelium morphology 0.0111194590868618 0.0634395744921303 1.93416544297602 0.833333333333333 1.1 1 1 absent midbrain 0.0111194590868618 0.0634395744921303 1.93416544297602 0.833333333333333 1.1 1 1 increased bone trabecular spacing 0.0111194590868618 0.0634395744921303 1.93416544297602 0.833333333333333 1.1 1 1 ectopic bone 0.0111194590868618 0.0634395744921303 1.93416544297602 0.833333333333333 1.1 1 1 increased cardiac cell glucose uptake 0.0111194590868618 0.0634395744921303 1.93416544297602 0.833333333333333 1.1 1 1 decreased atrioventricular cushion size 0.000594464145534409 0.0068778119163574 1.89899879855827 0.818181818181818 1.1 1 1 abnormal coronary vessel morphology 9.50792441424714e-05 0.00158911425252399 1.85679882525697 0.8 1.1 1 1 retarded hair growth 0.00163137183838142 0.0158827297376665 1.85679882525697 0.8 1.1 1 1 abnormal mammary gland physiology 0.00163137183838142 0.0158827297376665 1.85679882525697 0.8 1.1 1 1 absent inguinal lymph nodes 0.00163137183838142 0.0158827297376665 1.85679882525697 0.8 1.1 1 1 absent axillary lymph nodes 0.00163137183838142 0.0158827297376665 1.85679882525697 0.8 1.1 1 1 intestinal obstruction 0.000254912053925613 0.00357827963891112 1.82364170337739 0.785714285714286 1.1 1 1 abnormal embryonic hematopoiesis 2.82889978929991e-08 1.36638606327836e-06 1.81328010279001 0.78125 1.1 1 1 heart hyperplasia 0.00438730346026337 0.0328908024376711 1.80522108011095 0.777777777777778 1.1 1 1 abnormal geniculate ganglion morphology 0.00438730346026337 0.0328908024376711 1.80522108011095 0.777777777777778 1.1 1 1 abnormal kindling response 0.00438730346026337 0.0328908024376711 1.80522108011095 0.777777777777778 1.1 1 1 liver hyperplasia 0.00438730346026337 0.0328908024376711 1.80522108011095 0.777777777777778 1.1 1 1 eye opacity 0.00438730346026337 0.0328908024376711 1.80522108011095 0.777777777777778 1.1 1 1 prolonged RR interval 0.00438730346026337 0.0328908024376711 1.80522108011095 0.777777777777778 1.1 1 1 abnormal heart left ventricle pressure 0.00438730346026337 0.0328908024376711 1.80522108011095 0.777777777777778 1.1 1 1 increased cardiac muscle glycogen level 0.00438730346026337 0.0328908024376711 1.80522108011095 0.777777777777778 1.1 1 1 coloboma 0.000107320614091988 0.00173915327396625 1.77488123002505 0.764705882352941 1.1 1 1 abnormal neuron proliferation 4.48316812782396e-05 0.000851288604424587 1.74074889867841 0.75 1.1 1 1 decreased creatinine clearance 0.000275444411689493 0.00368608986724681 1.74074889867841 0.75 1.1 1 1 kidney degeneration 0.000275444411689493 0.00368608986724681 1.74074889867841 0.75 1.1 1 1 abnormal thymus involution 0.00173877345690747 0.0163523590701601 1.74074889867841 0.75 1.1 1 1 dilated bile duct 0.00173877345690747 0.0163523590701601 1.74074889867841 0.75 1.1 1 1 small intestinal inflammation 0.00173877345690747 0.0163523590701601 1.74074889867841 0.75 1.1 1 1 absent ovary 0.00173877345690747 0.0163523590701601 1.74074889867841 0.75 1.1 1 1 pale placenta 0.00173877345690747 0.0163523590701601 1.74074889867841 0.75 1.1 1 1 abnormal somatic nervous system physiology 0.00173877345690747 0.0163523590701601 1.74074889867841 0.75 1.1 1 1 persistent right dorsal aorta 0.00173877345690747 0.0163523590701601 1.74074889867841 0.75 1.1 1 1 abnormal pulmonary valve cusp morphology 0.00173877345690747 0.0163523590701601 1.74074889867841 0.75 1.1 1 1 spinning 0.0115081657353027 0.064113241358489 1.74074889867841 0.75 1.1 1 1 abnormal erythrocyte cell number 0.0115081657353027 0.064113241358489 1.74074889867841 0.75 1.1 1 1 decreased aerobic running capacity 0.0115081657353027 0.064113241358489 1.74074889867841 0.75 1.1 1 1 hypospadia 0.0115081657353027 0.064113241358489 1.74074889867841 0.75 1.1 1 1 abnormal umbilical artery morphology 0.0115081657353027 0.064113241358489 1.74074889867841 0.75 1.1 1 1 colon polyps 0.0115081657353027 0.064113241358489 1.74074889867841 0.75 1.1 1 1 pulmonary interstitial fibrosis 0.0115081657353027 0.064113241358489 1.74074889867841 0.75 1.1 1 1 abnormal eyelid aperture 0.0115081657353027 0.064113241358489 1.74074889867841 0.75 1.1 1 1 abnormal skin development 0.0115081657353027 0.064113241358489 1.74074889867841 0.75 1.1 1 1 tau protein deposits 0.0115081657353027 0.064113241358489 1.74074889867841 0.75 1.1 1 1 abnormal NK cell morphology 0.0115081657353027 0.064113241358489 1.74074889867841 0.75 1.1 1 1 abnormal somite size 0.0115081657353027 0.064113241358489 1.74074889867841 0.75 1.1 1 1 abnormal olfactory bulb mitral cell layer morphology 0.0115081657353027 0.064113241358489 1.74074889867841 0.75 1.1 1 1 abnormal anterior commissure pars posterior morphology 0.0115081657353027 0.064113241358489 1.74074889867841 0.75 1.1 1 1 abnormal bronchiole epithelium morphology 0.0115081657353027 0.064113241358489 1.74074889867841 0.75 1.1 1 1 increased airway resistance 0.0115081657353027 0.064113241358489 1.74074889867841 0.75 1.1 1 1 abnormal foramen magnum morphology 0.0115081657353027 0.064113241358489 1.74074889867841 0.75 1.1 1 1 small thymus medulla 0.0115081657353027 0.064113241358489 1.74074889867841 0.75 1.1 1 1 increased mammary gland apoptosis 0.0115081657353027 0.064113241358489 1.74074889867841 0.75 1.1 1 1 absent incisors 0.000694452280829252 0.00769465500473392 1.70206558981889 0.733333333333333 1.1 1 1 placental labyrinth hypoplasia 0.000694452280829252 0.00769465500473392 1.70206558981889 0.733333333333333 1.1 1 1 abnormal glial cell morphology 0.000694452280829252 0.00769465500473392 1.70206558981889 0.733333333333333 1.1 1 1 abnormal branching involved in lung morphogenesis 0.000694452280829252 0.00769465500473392 1.70206558981889 0.733333333333333 1.1 1 1 increased bone volume 4.62774821769597e-05 0.000868794240869337 1.6879989320518 0.727272727272727 1.1 1 1 abnormal proximal-distal axis patterning 0.00439645901930679 0.0328908024376711 1.6879989320518 0.727272727272727 1.1 1 1 cyclopia 0.00439645901930679 0.0328908024376711 1.6879989320518 0.727272727272727 1.1 1 1 abnormal mitral valve morphology 0.000279327815065738 0.00368608986724681 1.67627671724588 0.722222222222222 1.1 1 1 increased circulating renin level 0.000279327815065738 0.00368608986724681 1.67627671724588 0.722222222222222 1.1 1 1 long tibia 0.000279327815065738 0.00368608986724681 1.67627671724588 0.722222222222222 1.1 1 1 increased effector memory CD8-positive, alpha-beta T cell number 0.000279327815065738 0.00368608986724681 1.67627671724588 0.722222222222222 1.1 1 1 amyloid beta deposits 0.00171545189658141 0.0163523590701601 1.65785609397944 0.714285714285714 1.1 1 1 abnormal maternal decidual layer morphology 0.00171545189658141 0.0163523590701601 1.65785609397944 0.714285714285714 1.1 1 1 multiple persisting craniopharyngeal ducts 0.00171545189658141 0.0163523590701601 1.65785609397944 0.714285714285714 1.1 1 1 failure of atrioventricular cushion closure 0.0292489467039779 0.128432047530706 1.65785609397944 0.714285714285714 1.1 1 1 excessive tearing 0.0292489467039779 0.128432047530706 1.65785609397944 0.714285714285714 1.1 1 1 limp posture 0.0292489467039779 0.128432047530706 1.65785609397944 0.714285714285714 1.1 1 1 abnormal circulating free fatty acids level 0.0292489467039779 0.128432047530706 1.65785609397944 0.714285714285714 1.1 1 1 abnormal tumor incidence 0.0292489467039779 0.128432047530706 1.65785609397944 0.714285714285714 1.1 1 1 abnormal brain ventricular system morphology 0.0292489467039779 0.128432047530706 1.65785609397944 0.714285714285714 1.1 1 1 absent tunnel of Corti 0.0292489467039779 0.128432047530706 1.65785609397944 0.714285714285714 1.1 1 1 renal necrosis 0.0292489467039779 0.128432047530706 1.65785609397944 0.714285714285714 1.1 1 1 abnormal cochlear nerve compound action potential 0.0292489467039779 0.128432047530706 1.65785609397944 0.714285714285714 1.1 1 1 abnormal MHC II cell surface expression on macrophages 0.0292489467039779 0.128432047530706 1.65785609397944 0.714285714285714 1.1 1 1 abnormal gallbladder morphology 0.0292489467039779 0.128432047530706 1.65785609397944 0.714285714285714 1.1 1 1 atherosclerotic lesions 0.0292489467039779 0.128432047530706 1.65785609397944 0.714285714285714 1.1 1 1 abnormal renal/urinary system physiology 0.0292489467039779 0.128432047530706 1.65785609397944 0.714285714285714 1.1 1 1 uremia 0.0292489467039779 0.128432047530706 1.65785609397944 0.714285714285714 1.1 1 1 abnormal prostaglandin level 0.0292489467039779 0.128432047530706 1.65785609397944 0.714285714285714 1.1 1 1 abnormal sperm annulus morphology 0.0292489467039779 0.128432047530706 1.65785609397944 0.714285714285714 1.1 1 1 decreased T-helper 17 cell number 0.0292489467039779 0.128432047530706 1.65785609397944 0.714285714285714 1.1 1 1 heart block 0.0292489467039779 0.128432047530706 1.65785609397944 0.714285714285714 1.1 1 1 abnormal conotruncal ridge morphology 0.0292489467039779 0.128432047530706 1.65785609397944 0.714285714285714 1.1 1 1 abnormal aortic valve cusp morphology 0.0292489467039779 0.128432047530706 1.65785609397944 0.714285714285714 1.1 1 1 thick pulmonary valve 0.0292489467039779 0.128432047530706 1.65785609397944 0.714285714285714 1.1 1 1 increased right ventricle systolic pressure 0.0292489467039779 0.128432047530706 1.65785609397944 0.714285714285714 1.1 1 1 decreased CD8-positive, naive alpha-beta T cell number 0.0292489467039779 0.128432047530706 1.65785609397944 0.714285714285714 1.1 1 1 dysmyelination 0.0292489467039779 0.128432047530706 1.65785609397944 0.714285714285714 1.1 1 1 decreased hair follicle number 2.32244296918642e-07 8.75314679674426e-06 1.64913053559008 0.710526315789474 1.1 1 1 hemolytic anemia 4.59598229881838e-05 0.000866098936993236 1.64404062652961 0.708333333333333 1.1 1 1 abnormal testis development 0.000678941525923503 0.00759041368869534 1.63835190463851 0.705882352941177 1.1 1 1 abnormal cell proliferation 0.000271476994827721 0.00368608986724681 1.62469897209985 0.7 1.1 1 1 abnormal circulating enzyme level 0.000271476994827721 0.00368608986724681 1.62469897209985 0.7 1.1 1 1 anencephaly 0.000271476994827721 0.00368608986724681 1.62469897209985 0.7 1.1 1 1 abnormal Peyer's patch T cell area morphology 0.000271476994827721 0.00368608986724681 1.62469897209985 0.7 1.1 1 1 spleen atrophy 0.000271476994827721 0.00368608986724681 1.62469897209985 0.7 1.1 1 1 abnormal physiological neovascularization 0.000271476994827721 0.00368608986724681 1.62469897209985 0.7 1.1 1 1 absent ductus venosus valve 0.000271476994827721 0.00368608986724681 1.62469897209985 0.7 1.1 1 1 fused cornea and lens 0.0108178105779879 0.0633016694180401 1.62469897209985 0.7 1.1 1 1 impaired basement membrane formation 0.0108178105779879 0.0633016694180401 1.62469897209985 0.7 1.1 1 1 abnormal tibialis anterior morphology 0.0108178105779879 0.0633016694180401 1.62469897209985 0.7 1.1 1 1 peritoneal inflammation 0.0108178105779879 0.0633016694180401 1.62469897209985 0.7 1.1 1 1 bifid ureter 0.0108178105779879 0.0633016694180401 1.62469897209985 0.7 1.1 1 1 absent CD4-positive, alpha beta T cells 0.0108178105779879 0.0633016694180401 1.62469897209985 0.7 1.1 1 1 abnormal gas homeostasis 0.0108178105779879 0.0633016694180401 1.62469897209985 0.7 1.1 1 1 abnormal respiratory conducting tube morphology 0.0108178105779879 0.0633016694180401 1.62469897209985 0.7 1.1 1 1 abnormal cerebellar granule cell migration 0.0108178105779879 0.0633016694180401 1.62469897209985 0.7 1.1 1 1 abnormal retinal blood vessel pattern 0.0108178105779879 0.0633016694180401 1.62469897209985 0.7 1.1 1 1 acanthocytosis 0.0108178105779879 0.0633016694180401 1.62469897209985 0.7 1.1 1 1 thick aortic valve 0.0108178105779879 0.0633016694180401 1.62469897209985 0.7 1.1 1 1 decreased macrophage cytokine production 0.0108178105779879 0.0633016694180401 1.62469897209985 0.7 1.1 1 1 decreased macrophage apoptosis 0.0108178105779879 0.0633016694180401 1.62469897209985 0.7 1.1 1 1 decreased circulating lactate level 0.0108178105779879 0.0633016694180401 1.62469897209985 0.7 1.1 1 1 decreased circulating creatinine level 1.64480434589986e-08 8.70521449026789e-07 1.6104887770086 0.693877551020408 1.1 1 1 abnormal nasal bone morphology 4.43462283155721e-05 0.000848548022576813 1.60684513724161 0.692307692307692 1.1 1 1 abnormal bile duct development 0.00413854314333792 0.0315786075737825 1.60684513724161 0.692307692307692 1.1 1 1 increased mortality induced by gamma-irradiation 1.80643498313863e-05 0.000401205983978335 1.60068864246291 0.689655172413793 1.1 1 1 poor circulation 0.00161626959293673 0.0158598446249709 1.59568649045521 0.6875 1.1 1 1 abnormal epicardium morphology 0.00161626959293673 0.0158598446249709 1.59568649045521 0.6875 1.1 1 1 embryonic lethality between somite formation and embryo turning, incomplete penetrance 0.00161626959293673 0.0158598446249709 1.59568649045521 0.6875 1.1 1 1 abnormal triglyceride level 0.000640083317798156 0.00730370299551795 1.58805162686452 0.684210526315789 1.1 1 1 oliguria 0.000640083317798156 0.00730370299551795 1.58805162686452 0.684210526315789 1.1 1 1 decreased circulating magnesium level 0.000640083317798156 0.00730370299551795 1.58805162686452 0.684210526315789 1.1 1 1 decreased blood urea nitrogen level 2.12547524076069e-07 8.07193841433925e-06 1.58249899879856 0.681818181818182 1.1 1 1 intestinal inflammation 0.000256053779186404 0.00357827963891112 1.58249899879856 0.681818181818182 1.1 1 1 increased circulating creatine kinase level 0.000256053779186404 0.00357827963891112 1.58249899879856 0.681818181818182 1.1 1 1 abnormal keratinocyte physiology 0.000103211834976652 0.00169593493078694 1.57827900146843 0.68 1.1 1 1 abnormal cochlear outer hair cell morphology 0.000103211834976652 0.00169593493078694 1.57827900146843 0.68 1.1 1 1 abnormal mitotic spindle morphology 4.18513751796433e-05 0.000813322623120022 1.57496328928047 0.678571428571429 1.1 1 1 abnormal object recognition memory 1.70514272147847e-05 0.00038212094771871 1.57228932783857 0.67741935483871 1.1 1 1 abnormal placenta vasculature 3.44566207895126e-08 1.61718573988514e-06 1.56221055009601 0.673076923076923 1.1 1 1 extramedullary hematopoiesis 5.17920786320713e-15 9.54317004424276e-13 1.55463109190148 0.669811320754717 1.1 1 1 vascular ring 0.000588382012941418 0.00682331122233929 1.54733235438081 0.666666666666667 1.1 1 1 enlarged pericardium 1.58433805657309e-05 0.000363229577486227 1.54733235438081 0.666666666666667 1.1 1 1 abnormal brain vasculature morphology 3.88150292917022e-05 0.000766288772723089 1.54733235438081 0.666666666666667 1.1 1 1 abnormal atrioventricular cushion morphology 9.55065651265677e-05 0.00158911425252399 1.54733235438081 0.666666666666667 1.1 1 1 thin epidermis 9.55065651265677e-05 0.00158911425252399 1.54733235438081 0.666666666666667 1.1 1 1 prolonged QT interval 0.000236257225322636 0.00334866010250745 1.54733235438081 0.666666666666667 1.1 1 1 abnormal thyroid cartilage morphology 0.00147816894763903 0.0147077810290084 1.54733235438081 0.666666666666667 1.1 1 1 absent ureter 0.00147816894763903 0.0147077810290084 1.54733235438081 0.666666666666667 1.1 1 1 decreased hepatocyte number 0.00375745112808573 0.0294729225802342 1.54733235438081 0.666666666666667 1.1 1 1 abnormal pup retrieval 0.00375745112808573 0.0294729225802342 1.54733235438081 0.666666666666667 1.1 1 1 delayed intramembranous bone ossification 0.00375745112808573 0.0294729225802342 1.54733235438081 0.666666666666667 1.1 1 1 abnormal pericyte morphology 0.00375745112808573 0.0294729225802342 1.54733235438081 0.666666666666667 1.1 1 1 immune system phenotype 0.00375745112808573 0.0294729225802342 1.54733235438081 0.666666666666667 1.1 1 1 abnormal cerebral aqueduct morphology 0.00375745112808573 0.0294729225802342 1.54733235438081 0.666666666666667 1.1 1 1 ostium primum atrial septal defect 0.00375745112808573 0.0294729225802342 1.54733235438081 0.666666666666667 1.1 1 1 heterochrony 0.00375745112808573 0.0294729225802342 1.54733235438081 0.666666666666667 1.1 1 1 abnormal mineral level 0.00971183014410543 0.0590664486148222 1.54733235438081 0.666666666666667 1.1 1 1 abnormal glossopharyngeal nerve morphology 0.00971183014410543 0.0590664486148222 1.54733235438081 0.666666666666667 1.1 1 1 interstitial pneumonia 0.00971183014410543 0.0590664486148222 1.54733235438081 0.666666666666667 1.1 1 1 increased osteosarcoma incidence 0.00971183014410543 0.0590664486148222 1.54733235438081 0.666666666666667 1.1 1 1 decreased left ventricle systolic pressure 0.00971183014410543 0.0590664486148222 1.54733235438081 0.666666666666667 1.1 1 1 decreased cochlear nerve compound action potential 0.00971183014410543 0.0590664486148222 1.54733235438081 0.666666666666667 1.1 1 1 abnormal cochlear outer hair cell physiology 0.00971183014410543 0.0590664486148222 1.54733235438081 0.666666666666667 1.1 1 1 decreased red blood cell distribution width 0.00971183014410543 0.0590664486148222 1.54733235438081 0.666666666666667 1.1 1 1 increased skeletal muscle glycogen level 0.00971183014410543 0.0590664486148222 1.54733235438081 0.666666666666667 1.1 1 1 distorted hair follicle pattern 0.0257498902853812 0.122355018309237 1.54733235438081 0.666666666666667 1.1 1 1 decreased level of surface class I molecules 0.0257498902853812 0.122355018309237 1.54733235438081 0.666666666666667 1.1 1 1 abnormal taste sensitivity 0.0257498902853812 0.122355018309237 1.54733235438081 0.666666666666667 1.1 1 1 biliary cyst 0.0257498902853812 0.122355018309237 1.54733235438081 0.666666666666667 1.1 1 1 decreased cellular sensitivity to ionizing radiation 0.0257498902853812 0.122355018309237 1.54733235438081 0.666666666666667 1.1 1 1 decreased cochlear hair cell number 0.0257498902853812 0.122355018309237 1.54733235438081 0.666666666666667 1.1 1 1 abnormal hair cell mechanoelectric transduction 0.0257498902853812 0.122355018309237 1.54733235438081 0.666666666666667 1.1 1 1 abnormal gallbladder physiology 0.0257498902853812 0.122355018309237 1.54733235438081 0.666666666666667 1.1 1 1 decreased susceptibility to atherosclerosis 0.0257498902853812 0.122355018309237 1.54733235438081 0.666666666666667 1.1 1 1 positive geotaxis 0.0257498902853812 0.122355018309237 1.54733235438081 0.666666666666667 1.1 1 1 multiflagellated sperm 0.0257498902853812 0.122355018309237 1.54733235438081 0.666666666666667 1.1 1 1 abnormal telomere morphology 0.0257498902853812 0.122355018309237 1.54733235438081 0.666666666666667 1.1 1 1 iris coloboma 0.0257498902853812 0.122355018309237 1.54733235438081 0.666666666666667 1.1 1 1 decreased effector memory CD4-positive, alpha-beta T cell number 0.0257498902853812 0.122355018309237 1.54733235438081 0.666666666666667 1.1 1 1 abnormal pulmonary alveolar parenchyma morphology 0.0257498902853812 0.122355018309237 1.54733235438081 0.666666666666667 1.1 1 1 abnormal ductus venosus valve topology 0.0257498902853812 0.122355018309237 1.54733235438081 0.666666666666667 1.1 1 1 abnormal coronary sinus connection 0.0257498902853812 0.122355018309237 1.54733235438081 0.666666666666667 1.1 1 1 abnormal spongiotrophoblast layer morphology 3.55006044876446e-05 0.000715042539781506 1.52315528634361 0.65625 1.1 1 1 decreased trophoblast giant cell number 8.7046723341332e-05 0.00147298451912628 1.52065421033976 0.655172413793103 1.1 1 1 no spontaneous movement 0.000214402425336471 0.00313721195896748 1.51757596295041 0.653846153846154 1.1 1 1 abnormal hematopoietic stem cell physiology 0.000531044070599033 0.00623100059252403 1.51369469450297 0.652173913043478 1.1 1 1 delayed endochondral bone ossification 2.24214038195786e-06 6.80161487819534e-05 1.51134788102312 0.651162790697674 1.1 1 1 head bobbing 5.43177444848147e-06 0.000147136870951291 1.50864904552129 0.65 1.1 1 1 increased urine calcium level 0.00132463791760038 0.0133402300406112 1.50864904552129 0.65 1.1 1 1 abnormal lung development 4.68767602113224e-11 4.48484388560248e-09 1.50182257925197 0.647058823529412 1.1 1 1 lung hemorrhage 3.21031777630685e-05 0.000657256417165702 1.50182257925197 0.647058823529412 1.1 1 1 abnormal vagus nerve morphology 0.00333470438246099 0.0269758606548673 1.50182257925197 0.647058823529412 1.1 1 1 abnormal heart rate 0.00333470438246099 0.0269758606548673 1.50182257925197 0.647058823529412 1.1 1 1 abnormal involuntary movement 0.00333470438246099 0.0269758606548673 1.50182257925197 0.647058823529412 1.1 1 1 abnormal tarsal bone morphology 0.00333470438246099 0.0269758606548673 1.50182257925197 0.647058823529412 1.1 1 1 increased hepatoma incidence 0.00333470438246099 0.0269758606548673 1.50182257925197 0.647058823529412 1.1 1 1 abnormal electroretinogram waveform feature 0.00333470438246099 0.0269758606548673 1.50182257925197 0.647058823529412 1.1 1 1 trabecula carnea hypoplasia 2.02947629237725e-06 6.2712077978738e-05 1.49575460923479 0.644444444444444 1.1 1 1 shortened head 0.000192085907031031 0.00287839574541981 1.4920704845815 0.642857142857143 1.1 1 1 prolonged QRS complex duration 0.000192085907031031 0.00287839574541981 1.4920704845815 0.642857142857143 1.1 1 1 subcutaneous edema 0.000192085907031031 0.00287839574541981 1.4920704845815 0.642857142857143 1.1 1 1 abnormal blood flow velocity 0.00850010738749963 0.0532594889833887 1.4920704845815 0.642857142857143 1.1 1 1 abnormal spleen periarteriolar lymphoid sheath morphology 0.00850010738749963 0.0532594889833887 1.4920704845815 0.642857142857143 1.1 1 1 increased hemangioma incidence 0.00850010738749963 0.0532594889833887 1.4920704845815 0.642857142857143 1.1 1 1 failure of zygotic cell division 0.00850010738749963 0.0532594889833887 1.4920704845815 0.642857142857143 1.1 1 1 abnormal voluntary movement 0.00850010738749963 0.0532594889833887 1.4920704845815 0.642857142857143 1.1 1 1 vascular smooth muscle hypoplasia 0.00850010738749963 0.0532594889833887 1.4920704845815 0.642857142857143 1.1 1 1 split sternum 0.00850010738749963 0.0532594889833887 1.4920704845815 0.642857142857143 1.1 1 1 abnormal viscerocranium morphology 0.00850010738749963 0.0532594889833887 1.4920704845815 0.642857142857143 1.1 1 1 decreased cornea thickness 0.00850010738749963 0.0532594889833887 1.4920704845815 0.642857142857143 1.1 1 1 decreased tongue size 0.00850010738749963 0.0532594889833887 1.4920704845815 0.642857142857143 1.1 1 1 abnormal renal tubule epithelial cell primary cilium morphology 0.00850010738749963 0.0532594889833887 1.4920704845815 0.642857142857143 1.1 1 1 decreased response to antigen 0.00850010738749963 0.0532594889833887 1.4920704845815 0.642857142857143 1.1 1 1 impaired macrophage chemotaxis 1.18617236588469e-05 0.000283711900013285 1.48781957152001 0.641025641025641 1.1 1 1 mandible hypoplasia 0.000472782363715496 0.00564050901555058 1.48543906020558 0.64 1.1 1 1 abnormal egg cylinder morphology 0.000472782363715496 0.00564050901555058 1.48543906020558 0.64 1.1 1 1 heart right ventricle hypertrophy 2.87608776947943e-05 0.000591261845171907 1.48286017294828 0.638888888888889 1.1 1 1 impaired wound healing 2.87608776947943e-05 0.000591261845171907 1.48286017294828 0.638888888888889 1.1 1 1 renal hypoplasia 2.87608776947943e-05 0.000591261845171907 1.48286017294828 0.638888888888889 1.1 1 1 abnormal retinal blood vessel morphology 2.87608776947943e-05 0.000591261845171907 1.48286017294828 0.638888888888889 1.1 1 1 pale yolk sac 2.18586711516824e-10 1.81244814966033e-08 1.48208339967801 0.63855421686747 1.1 1 1 decreased circulating total protein level 2.8360530228363e-07 1.0451380584156e-05 1.47699906554532 0.636363636363636 1.1 1 1 increased skin papilloma incidence 0.00116995642201269 0.0120757950197368 1.47699906554532 0.636363636363636 1.1 1 1 increased myocardial infarction size 0.00116995642201269 0.0120757950197368 1.47699906554532 0.636363636363636 1.1 1 1 prolonged PR interval 0.00116995642201269 0.0120757950197368 1.47699906554532 0.636363636363636 1.1 1 1 abnormal sperm midpiece morphology 0.00116995642201269 0.0120757950197368 1.47699906554532 0.636363636363636 1.1 1 1 impaired humoral immune response 0.00116995642201269 0.0120757950197368 1.47699906554532 0.636363636363636 1.1 1 1 premature suture closure 0.0220551758056799 0.108209565713272 1.47699906554532 0.636363636363636 1.1 1 1 abnormal sphenoid bone morphology 0.0220551758056799 0.108209565713272 1.47699906554532 0.636363636363636 1.1 1 1 abnormal thrombopoiesis 0.0220551758056799 0.108209565713272 1.47699906554532 0.636363636363636 1.1 1 1 loss of cortex neurons 0.0220551758056799 0.108209565713272 1.47699906554532 0.636363636363636 1.1 1 1 pulmonary hypertension 0.0220551758056799 0.108209565713272 1.47699906554532 0.636363636363636 1.1 1 1 abnormal ureter development 0.0220551758056799 0.108209565713272 1.47699906554532 0.636363636363636 1.1 1 1 pathological neovascularization 0.0220551758056799 0.108209565713272 1.47699906554532 0.636363636363636 1.1 1 1 abnormal palate development 0.0220551758056799 0.108209565713272 1.47699906554532 0.636363636363636 1.1 1 1 abnormal aorta smooth muscle morphology 0.0220551758056799 0.108209565713272 1.47699906554532 0.636363636363636 1.1 1 1 abnormal palatal shelf elevation 0.0220551758056799 0.108209565713272 1.47699906554532 0.636363636363636 1.1 1 1 common atrioventricular valve 0.0220551758056799 0.108209565713272 1.47699906554532 0.636363636363636 1.1 1 1 reduced sympathetic cervical ganglion size 0.0220551758056799 0.108209565713272 1.47699906554532 0.636363636363636 1.1 1 1 liver hypoplasia 6.7948707882711e-07 2.3805973360316e-05 1.47294137580481 0.634615384615385 1.1 1 1 thick ventricular wall 1.05882835149926e-05 0.000262073186502927 1.47185272733785 0.634146341463415 1.1 1 1 abnormal optic cup morphology 0.00017035601306342 0.00260775743074004 1.46996573666177 0.633333333333333 1.1 1 1 abnormal fat pad morphology 0.00017035601306342 0.00260775743074004 1.46996573666177 0.633333333333333 1.1 1 1 abnormal placenta morphology 1.1104128108105e-09 7.8600115756863e-08 1.46898641238685 0.632911392405063 1.1 1 1 abnormal reproductive system physiology 2.55665530201758e-05 0.000541249367129255 1.4658938094134 0.631578947368421 1.1 1 1 kyphoscoliosis 0.00291488717022339 0.0243314826709083 1.4658938094134 0.631578947368421 1.1 1 1 thin dermal layer 0.00291488717022339 0.0243314826709083 1.4658938094134 0.631578947368421 1.1 1 1 unresponsive to tactile stimuli 0.00291488717022339 0.0243314826709083 1.4658938094134 0.631578947368421 1.1 1 1 altered susceptibility to infection 0.00291488717022339 0.0243314826709083 1.4658938094134 0.631578947368421 1.1 1 1 decreased germ cell number 0.00291488717022339 0.0243314826709083 1.4658938094134 0.631578947368421 1.1 1 1 decreased eye pigmentation 0.00291488717022339 0.0243314826709083 1.4658938094134 0.631578947368421 1.1 1 1 decreased liver regeneration 0.00291488717022339 0.0243314826709083 1.4658938094134 0.631578947368421 1.1 1 1 embryonic lethality between implantation and somite formation, incomplete penetrance 0.00291488717022339 0.0243314826709083 1.4658938094134 0.631578947368421 1.1 1 1 abnormal heart valve morphology 0.000416525387693305 0.00515476070590595 1.4613694458041 0.62962962962963 1.1 1 1 abnormal trigeminal nerve morphology 0.000416525387693305 0.00515476070590595 1.4613694458041 0.62962962962963 1.1 1 1 abnormal type II pneumocyte morphology 0.000416525387693305 0.00515476070590595 1.4613694458041 0.62962962962963 1.1 1 1 abnormal liver development 6.18384890241627e-05 0.00111466116991018 1.45891336270191 0.628571428571429 1.1 1 1 abnormal artery morphology 6.18384890241627e-05 0.00111466116991018 1.45891336270191 0.628571428571429 1.1 1 1 enhanced long term potentiation 5.37031152051263e-07 1.92210790032736e-05 1.45062408223201 0.625 1.1 1 1 overriding aortic valve 3.46145558254935e-06 0.000100706090778848 1.45062408223201 0.625 1.1 1 1 kidney cortex cysts 0.000149859565550186 0.00232258983991332 1.45062408223201 0.625 1.1 1 1 failure of primitive streak formation 0.000149859565550186 0.00232258983991332 1.45062408223201 0.625 1.1 1 1 increased fibroblast apoptosis 0.000149859565550186 0.00232258983991332 1.45062408223201 0.625 1.1 1 1 abnormal cardiac muscle contractility 0.00102235547939302 0.0107758866736871 1.45062408223201 0.625 1.1 1 1 failure of tooth eruption 0.00732608702000074 0.0491203273915144 1.45062408223201 0.625 1.1 1 1 abnormal hair follicle orientation 0.00732608702000074 0.0491203273915144 1.45062408223201 0.625 1.1 1 1 delayed hair appearance 0.00732608702000074 0.0491203273915144 1.45062408223201 0.625 1.1 1 1 disorganized retinal layers 0.00732608702000074 0.0491203273915144 1.45062408223201 0.625 1.1 1 1 abnormal extraembryonic endoderm formation 0.00732608702000074 0.0491203273915144 1.45062408223201 0.625 1.1 1 1 small epididymis 0.00732608702000074 0.0491203273915144 1.45062408223201 0.625 1.1 1 1 decreased circulating triiodothyronine level 0.00732608702000074 0.0491203273915144 1.45062408223201 0.625 1.1 1 1 abnormal pulmonary alveolus wall morphology 0.00732608702000074 0.0491203273915144 1.45062408223201 0.625 1.1 1 1 abnormal ear pigmentation 0.0588169149851032 0.210817112428594 1.45062408223201 0.625 1.1 1 1 pointed snout 0.0588169149851032 0.210817112428594 1.45062408223201 0.625 1.1 1 1 abnormal urination 0.0588169149851032 0.210817112428594 1.45062408223201 0.625 1.1 1 1 abnormal atrial thrombosis 0.0588169149851032 0.210817112428594 1.45062408223201 0.625 1.1 1 1 abnormal hepatobiliary system morphology 0.0588169149851032 0.210817112428594 1.45062408223201 0.625 1.1 1 1 short ureter 0.0588169149851032 0.210817112428594 1.45062408223201 0.625 1.1 1 1 decreased corneal stroma thickness 0.0588169149851032 0.210817112428594 1.45062408223201 0.625 1.1 1 1 decreased susceptibility to age related obesity 0.0588169149851032 0.210817112428594 1.45062408223201 0.625 1.1 1 1 abnormal perineum morphology 0.0588169149851032 0.210817112428594 1.45062408223201 0.625 1.1 1 1 liver failure 0.0588169149851032 0.210817112428594 1.45062408223201 0.625 1.1 1 1 increased cardiac output 0.0588169149851032 0.210817112428594 1.45062408223201 0.625 1.1 1 1 abnormal extraembryonic tissue physiology 0.0588169149851032 0.210817112428594 1.45062408223201 0.625 1.1 1 1 long femur 0.0588169149851032 0.210817112428594 1.45062408223201 0.625 1.1 1 1 accumulation of giant lysosomes in kidney/renal tubule cells 0.0588169149851032 0.210817112428594 1.45062408223201 0.625 1.1 1 1 abnormal choroid pigmentation 0.0588169149851032 0.210817112428594 1.45062408223201 0.625 1.1 1 1 non-pigmented tail tip 0.0588169149851032 0.210817112428594 1.45062408223201 0.625 1.1 1 1 Sertoli cell hypoplasia 0.0588169149851032 0.210817112428594 1.45062408223201 0.625 1.1 1 1 stomach epithelial hyperplasia 0.0588169149851032 0.210817112428594 1.45062408223201 0.625 1.1 1 1 absent outer ear 0.0588169149851032 0.210817112428594 1.45062408223201 0.625 1.1 1 1 abnormal cerebellum deep nucleus morphology 0.0588169149851032 0.210817112428594 1.45062408223201 0.625 1.1 1 1 increased caudal vertebrae number 0.0588169149851032 0.210817112428594 1.45062408223201 0.625 1.1 1 1 abnormal lateral plate mesoderm morphology 0.0588169149851032 0.210817112428594 1.45062408223201 0.625 1.1 1 1 pleural effusion 0.0588169149851032 0.210817112428594 1.45062408223201 0.625 1.1 1 1 sinoatrial block 0.0588169149851032 0.210817112428594 1.45062408223201 0.625 1.1 1 1 delayed suture closure 0.0588169149851032 0.210817112428594 1.45062408223201 0.625 1.1 1 1 abnormal visual evoked potential 0.0588169149851032 0.210817112428594 1.45062408223201 0.625 1.1 1 1 abnormal stomach position or orientation 0.0588169149851032 0.210817112428594 1.45062408223201 0.625 1.1 1 1 decreased alveolar lamellar body number 0.0588169149851032 0.210817112428594 1.45062408223201 0.625 1.1 1 1 increased aorta wall thickness 0.0588169149851032 0.210817112428594 1.45062408223201 0.625 1.1 1 1 abnormal macrophage activation involved in immune response 0.0588169149851032 0.210817112428594 1.45062408223201 0.625 1.1 1 1 increased testis apoptosis 0.0588169149851032 0.210817112428594 1.45062408223201 0.625 1.1 1 1 absent hypoglossal canal 0.0588169149851032 0.210817112428594 1.45062408223201 0.625 1.1 1 1 abnormal umbilical vein topology 0.0588169149851032 0.210817112428594 1.45062408223201 0.625 1.1 1 1 increased brain apoptosis 0.0588169149851032 0.210817112428594 1.45062408223201 0.625 1.1 1 1 decreased basal metabolism 0.0588169149851032 0.210817112428594 1.45062408223201 0.625 1.1 1 1 hydrops fetalis 1.323421588452e-08 7.15654608972685e-07 1.45062408223201 0.625 1.1 1 1 decreased hemoglobin content 2.11528787673456e-15 4.57545964641498e-13 1.44856645942033 0.624113475177305 1.1 1 1 polyuria 4.95590845417008e-09 3.04390673574027e-07 1.44685622747297 0.623376623376623 1.1 1 1 abnormal hepatocyte morphology 2.83482489315004e-12 3.4398180105906e-10 1.4427828709767 0.621621621621622 1.1 1 1 lethality throughout fetal growth and development, complete penetrance 6.81222711535178e-20 3.38908298988751e-17 1.44146224592318 0.621052631578947 1.1 1 1 short sternum 0.000363968207614174 0.00463105328102434 1.44061977821662 0.620689655172414 1.1 1 1 increased retinal apoptosis 0.000363968207614174 0.00463105328102434 1.44061977821662 0.620689655172414 1.1 1 1 abnormal erythropoiesis 1.56863996294507e-11 1.66042208843654e-09 1.43680861478218 0.619047619047619 1.1 1 1 abnormal reproductive system morphology 1.98283732331008e-05 0.000436487419622462 1.43680861478218 0.619047619047619 1.1 1 1 abnormal eye pigmentation 0.00252105376267121 0.0219653983700338 1.43680861478218 0.619047619047619 1.1 1 1 left pulmonary isomerism 0.00252105376267121 0.0219653983700338 1.43680861478218 0.619047619047619 1.1 1 1 abnormal erythrocyte physiology 0.00252105376267121 0.0219653983700338 1.43680861478218 0.619047619047619 1.1 1 1 abnormal brown adipose tissue morphology 0.000130958357146872 0.00208152660321306 1.43355791655869 0.617647058823529 1.1 1 1 increased circulating alanine transaminase level 9.1183426615631e-09 5.09705109452544e-07 1.42830678865921 0.615384615384615 1.1 1 1 ventricular hypoplasia 0.00088619026512194 0.00952223880989557 1.42830678865921 0.615384615384615 1.1 1 1 abnormal ocular fundus morphology 0.00088619026512194 0.00952223880989557 1.42830678865921 0.615384615384615 1.1 1 1 absent trabeculae carneae 0.0186290893453335 0.0950362247095564 1.42830678865921 0.615384615384615 1.1 1 1 excessive scratching 0.0186290893453335 0.0950362247095564 1.42830678865921 0.615384615384615 1.1 1 1 abnormal soleus morphology 0.0186290893453335 0.0950362247095564 1.42830678865921 0.615384615384615 1.1 1 1 small otic vesicle 0.0186290893453335 0.0950362247095564 1.42830678865921 0.615384615384615 1.1 1 1 increased cochlear inner hair cell number 0.0186290893453335 0.0950362247095564 1.42830678865921 0.615384615384615 1.1 1 1 abnormal exocrine pancreas morphology 0.0186290893453335 0.0950362247095564 1.42830678865921 0.615384615384615 1.1 1 1 increased renin activity 0.0186290893453335 0.0950362247095564 1.42830678865921 0.615384615384615 1.1 1 1 increased prostaglandin level 0.0186290893453335 0.0950362247095564 1.42830678865921 0.615384615384615 1.1 1 1 absent hypoglossal nerve 0.0186290893453335 0.0950362247095564 1.42830678865921 0.615384615384615 1.1 1 1 embryonic lethality between somite formation and embryo turning, complete penetrance 5.76199887516688e-08 2.53680923928807e-06 1.42575624082232 0.614285714285714 1.1 1 1 osteopetrosis 0.000315976443510848 0.00409370522517309 1.42254748709204 0.612903225806452 1.1 1 1 absent mature ovarian follicles 0.000315976443510848 0.00409370522517309 1.42254748709204 0.612903225806452 1.1 1 1 decreased thymus weight 0.000315976443510848 0.00409370522517309 1.42254748709204 0.612903225806452 1.1 1 1 pale kidney 0.000315976443510848 0.00409370522517309 1.42254748709204 0.612903225806452 1.1 1 1 abnormal heart shape 0.00625211720860976 0.0432003932122688 1.41838799151574 0.611111111111111 1.1 1 1 absent spleen 0.00625211720860976 0.0432003932122688 1.41838799151574 0.611111111111111 1.1 1 1 abnormal thymus cortex morphology 0.00625211720860976 0.0432003932122688 1.41838799151574 0.611111111111111 1.1 1 1 abnormal Peyer's patch follicle morphology 0.00625211720860976 0.0432003932122688 1.41838799151574 0.611111111111111 1.1 1 1 abnormal bile duct morphology 0.00625211720860976 0.0432003932122688 1.41838799151574 0.611111111111111 1.1 1 1 acidosis 0.00625211720860976 0.0432003932122688 1.41838799151574 0.611111111111111 1.1 1 1 abnormal metacarpal bone morphology 0.00625211720860976 0.0432003932122688 1.41838799151574 0.611111111111111 1.1 1 1 atrioventricular block 0.00625211720860976 0.0432003932122688 1.41838799151574 0.611111111111111 1.1 1 1 primary atelectasis 0.00625211720860976 0.0432003932122688 1.41838799151574 0.611111111111111 1.1 1 1 increased effector memory CD4-positive, alpha-beta T cell number 0.00625211720860976 0.0432003932122688 1.41838799151574 0.611111111111111 1.1 1 1 abnormal metanephric mesenchyme morphology 0.00625211720860976 0.0432003932122688 1.41838799151574 0.611111111111111 1.1 1 1 abnormal cell differentiation 4.13127153028884e-05 0.000808467844976483 1.41524300705562 0.609756097560976 1.1 1 1 abnormal nasal cavity morphology 0.00216382007976726 0.0196441695197849 1.41278171486944 0.608695652173913 1.1 1 1 decreased epididymis weight 0.00216382007976726 0.0196441695197849 1.41278171486944 0.608695652173913 1.1 1 1 abnormal corneal stroma morphology 0.00216382007976726 0.0196441695197849 1.41278171486944 0.608695652173913 1.1 1 1 abnormal vertebral artery topology 0.00216382007976726 0.0196441695197849 1.41278171486944 0.608695652173913 1.1 1 1 pale liver 4.41506945136605e-08 1.99681550186783e-06 1.41141802595547 0.608108108108108 1.1 1 1 kidney cysts 4.41506945136605e-08 1.99681550186783e-06 1.41141802595547 0.608108108108108 1.1 1 1 abnormal trophoblast layer morphology 5.5338898034463e-06 0.000148816766335921 1.41080302899427 0.607843137254902 1.1 1 1 premature aging 0.000763386403262273 0.00836530254676169 1.40917767988253 0.607142857142857 1.1 1 1 abnormal ovarian folliculogenesis 0.000272873133548945 0.00368608986724681 1.40666577670983 0.606060606060606 1.1 1 1 decreased brown adipose tissue amount 0.000272873133548945 0.00368608986724681 1.40666577670983 0.606060606060606 1.1 1 1 dilated heart atrium 0.000272873133548945 0.00368608986724681 1.40666577670983 0.606060606060606 1.1 1 1 impaired branching involved in ureteric bud morphogenesis 9.84710817074585e-05 0.00163297877164869 1.40481490068784 0.605263157894737 1.1 1 1 abnormal vasculogenesis 3.57918532676628e-05 0.000717723771662718 1.40339446095004 0.604651162790698 1.1 1 1 thymus atrophy 1.30828475502149e-05 0.000307014936614712 1.40226994615761 0.604166666666667 1.1 1 1 absent gastric milk in neonates 3.35081354604599e-08 1.60291321072873e-06 1.39855039722881 0.602564102564103 1.1 1 1 abnormal contextual conditioning behavior 4.15787233335996e-06 0.000116866750612801 1.39259911894273 0.6 1.1 1 1 abnormal learning/memory/conditioning 4.15787233335996e-06 0.000116866750612801 1.39259911894273 0.6 1.1 1 1 abnormal interventricular septum morphology 1.13112612545249e-05 0.000275850611476772 1.39259911894273 0.6 1.1 1 1 increased B cell derived lymphoma incidence 1.13112612545249e-05 0.000275850611476772 1.39259911894273 0.6 1.1 1 1 abnormal embryonic epiblast morphology 0.000234638159330934 0.00333521383620399 1.39259911894273 0.6 1.1 1 1 holoprosencephaly 0.000234638159330934 0.00333521383620399 1.39259911894273 0.6 1.1 1 1 decreased circulating thyroxine level 0.000234638159330934 0.00333521383620399 1.39259911894273 0.6 1.1 1 1 abnormal primitive streak morphology 0.00184671515290932 0.0171153901812462 1.39259911894273 0.6 1.1 1 1 increased pre-B cell number 0.00184671515290932 0.0171153901812462 1.39259911894273 0.6 1.1 1 1 absent mesoderm 1.53368533418839e-06 4.92263518554015e-05 1.39259911894273 0.6 1.1 1 1 muscular ventricular septal defect 1.53368533418839e-06 4.92263518554015e-05 1.39259911894273 0.6 1.1 1 1 emphysema 0.000654386499440304 0.00744982342040163 1.39259911894273 0.6 1.1 1 1 abnormal hyoid bone morphology 0.0053002610491579 0.0381603454696969 1.39259911894273 0.6 1.1 1 1 absent placental labyrinth 0.0053002610491579 0.0381603454696969 1.39259911894273 0.6 1.1 1 1 abnormal heart electrocardiography waveform feature 0.0053002610491579 0.0381603454696969 1.39259911894273 0.6 1.1 1 1 vagina atresia 0.0156140917766205 0.0818546960892381 1.39259911894273 0.6 1.1 1 1 abnormal seizure response to electrical stimulation 0.0156140917766205 0.0818546960892381 1.39259911894273 0.6 1.1 1 1 increased airway responsiveness 0.0156140917766205 0.0818546960892381 1.39259911894273 0.6 1.1 1 1 abnormal lymph node B cell domain morphology 0.0156140917766205 0.0818546960892381 1.39259911894273 0.6 1.1 1 1 abnormal olfactory nerve morphology 0.0156140917766205 0.0818546960892381 1.39259911894273 0.6 1.1 1 1 abnormal Muller cell morphology 0.0156140917766205 0.0818546960892381 1.39259911894273 0.6 1.1 1 1 abnormal aorta wall morphology 0.0156140917766205 0.0818546960892381 1.39259911894273 0.6 1.1 1 1 lactation failure 0.0156140917766205 0.0818546960892381 1.39259911894273 0.6 1.1 1 1 enlarged testis 0.0481480098464711 0.183412212087438 1.39259911894273 0.6 1.1 1 1 abnormal prostate gland epithelium morphology 0.0481480098464711 0.183412212087438 1.39259911894273 0.6 1.1 1 1 abnormal epidermis suprabasal layer morphology 0.0481480098464711 0.183412212087438 1.39259911894273 0.6 1.1 1 1 abnormal immune cell physiology 0.0481480098464711 0.183412212087438 1.39259911894273 0.6 1.1 1 1 decreased incidence of induced tumors 0.0481480098464711 0.183412212087438 1.39259911894273 0.6 1.1 1 1 ketoaciduria 0.0481480098464711 0.183412212087438 1.39259911894273 0.6 1.1 1 1 acrania 0.0481480098464711 0.183412212087438 1.39259911894273 0.6 1.1 1 1 cochlear ganglion hypoplasia 0.0481480098464711 0.183412212087438 1.39259911894273 0.6 1.1 1 1 absent seminal vesicle 0.0481480098464711 0.183412212087438 1.39259911894273 0.6 1.1 1 1 abnormal glial cell physiology 0.0481480098464711 0.183412212087438 1.39259911894273 0.6 1.1 1 1 abnormal pillar cell morphology 0.0481480098464711 0.183412212087438 1.39259911894273 0.6 1.1 1 1 abnormal ear physiology 0.0481480098464711 0.183412212087438 1.39259911894273 0.6 1.1 1 1 increased heart rate variability 0.0481480098464711 0.183412212087438 1.39259911894273 0.6 1.1 1 1 abnormal embryonic erythrocyte morphology 0.0481480098464711 0.183412212087438 1.39259911894273 0.6 1.1 1 1 abnormal corneal endothelium morphology 0.0481480098464711 0.183412212087438 1.39259911894273 0.6 1.1 1 1 increased susceptibility to atherosclerosis 0.0481480098464711 0.183412212087438 1.39259911894273 0.6 1.1 1 1 osteosclerosis 0.0481480098464711 0.183412212087438 1.39259911894273 0.6 1.1 1 1 vascular smooth muscle hyperplasia 0.0481480098464711 0.183412212087438 1.39259911894273 0.6 1.1 1 1 increased platelet aggregation 0.0481480098464711 0.183412212087438 1.39259911894273 0.6 1.1 1 1 abnormal spinal cord dorsal column morphology 0.0481480098464711 0.183412212087438 1.39259911894273 0.6 1.1 1 1 abnormal sperm principal piece morphology 0.0481480098464711 0.183412212087438 1.39259911894273 0.6 1.1 1 1 decreased transitional stage T2 B cell number 0.0481480098464711 0.183412212087438 1.39259911894273 0.6 1.1 1 1 increased circulating fructosamine level 0.0481480098464711 0.183412212087438 1.39259911894273 0.6 1.1 1 1 abnormal heart and great artery attachment 0.0481480098464711 0.183412212087438 1.39259911894273 0.6 1.1 1 1 abnormal left subclavian artery morphology 0.0481480098464711 0.183412212087438 1.39259911894273 0.6 1.1 1 1 thin ventricle myocardium compact layer 0.0481480098464711 0.183412212087438 1.39259911894273 0.6 1.1 1 1 thick aortic valve cusps 0.0481480098464711 0.183412212087438 1.39259911894273 0.6 1.1 1 1 abnormal adaptive thermogenesis 0.0481480098464711 0.183412212087438 1.39259911894273 0.6 1.1 1 1 increased fatty acid oxidation 0.0481480098464711 0.183412212087438 1.39259911894273 0.6 1.1 1 1 decreased cardiac muscle contractility 4.26214139151726e-10 3.26217744966129e-08 1.38367220151361 0.596153846153846 1.1 1 1 pulmonary hypoplasia 2.66008780787189e-05 0.00055839395966931 1.38272252944668 0.595744680851064 1.1 1 1 hydronephrosis 2.18286663982939e-08 1.09694560940921e-06 1.38154674498287 0.595238095238095 1.1 1 1 spina bifida 7.29073359937521e-05 0.00128894510027339 1.38154674498287 0.595238095238095 1.1 1 1 increased brown adipose tissue amount 0.000201044565477226 0.00298566183059462 1.38005318093424 0.594594594594595 1.1 1 1 impaired skeletal muscle contractility 0.000201044565477226 0.00298566183059462 1.38005318093424 0.594594594594595 1.1 1 1 increased lymphocyte cell number 4.23735742498062e-07 1.5275980571941e-05 1.37914405499159 0.594202898550725 1.1 1 1 polydipsia 0.000558762649761044 0.00652545582760844 1.37809287812041 0.59375 1.1 1 1 edema 1.90146350522895e-15 4.50465758976859e-13 1.37640610593177 0.593023255813954 1.1 1 1 increased circulating creatinine level 1.88588924592736e-08 9.77322812342562e-07 1.37640610593177 0.593023255813954 1.1 1 1 abnormal trigeminal ganglion morphology 0.00156933917774541 0.0155217940542414 1.37540653722739 0.592592592592593 1.1 1 1 increased brain weight 0.00156933917774541 0.0155217940542414 1.37540653722739 0.592592592592593 1.1 1 1 decreased urine osmolality 2.28390060336631e-05 0.000491879026049671 1.37365219215439 0.591836734693878 1.1 1 1 abnormal tail movements 0.00447263881028907 0.0329973643693365 1.37149913229208 0.590909090909091 1.1 1 1 increased coping response 0.00447263881028907 0.0329973643693365 1.37149913229208 0.590909090909091 1.1 1 1 abnormal vascular branching morphogenesis 0.00447263881028907 0.0329973643693365 1.37149913229208 0.590909090909091 1.1 1 1 abnormal cochlear sensory epithelium morphology 0.00447263881028907 0.0329973643693365 1.37149913229208 0.590909090909091 1.1 1 1 abnormal circulating lipid level 0.00447263881028907 0.0329973643693365 1.37149913229208 0.590909090909091 1.1 1 1 embryonic lethality before implantation, incomplete penetrance 0.00447263881028907 0.0329973643693365 1.37149913229208 0.590909090909091 1.1 1 1 abnormal vascular development 9.84045812808732e-07 3.33035912838329e-05 1.37149913229208 0.590909090909091 1.1 1 1 abnormal heart looping 0.00017175023416437 0.00262103501523847 1.36879400579841 0.58974358974359 1.1 1 1 enlarged liver sinusoidal spaces 0.00047560852840905 0.00566065174362446 1.36529325386542 0.588235294117647 1.1 1 1 distended urinary bladder 0.0130280622164861 0.070297841135595 1.36529325386542 0.588235294117647 1.1 1 1 decreased vasoconstriction 0.0130280622164861 0.070297841135595 1.36529325386542 0.588235294117647 1.1 1 1 aminoaciduria 0.0130280622164861 0.070297841135595 1.36529325386542 0.588235294117647 1.1 1 1 increased regulatory T cell number 0.0130280622164861 0.070297841135595 1.36529325386542 0.588235294117647 1.1 1 1 abnormal ectoplacental cone morphology 0.0130280622164861 0.070297841135595 1.36529325386542 0.588235294117647 1.1 1 1 cleft palate 9.37013443533632e-12 1.05946406399541e-09 1.36425104527469 0.587786259541985 1.1 1 1 abnormal inner ear morphology 5.33795851224581e-05 0.000978830654881549 1.36232522505267 0.58695652173913 1.1 1 1 abnormal cell death 5.33795851224581e-05 0.000978830654881549 1.36232522505267 0.58695652173913 1.1 1 1 failure to gastrulate 5.33795851224581e-05 0.000978830654881549 1.36232522505267 0.58695652173913 1.1 1 1 perinatal lethality, complete penetrance 4.47357925819524e-18 1.48373712063476e-15 1.36208834012395 0.586854460093897 1.1 1 1 abnormal mammary gland development 0.000146358396086771 0.00228972647965938 1.3586332867734 0.585365853658537 1.1 1 1 palatal shelves fail to meet at midline 0.000146358396086771 0.00228972647965938 1.3586332867734 0.585365853658537 1.1 1 1 atrioventricular septal defect 1.67262815973072e-05 0.000376530547269697 1.35756517884354 0.584905660377358 1.1 1 1 increased spleen weight 4.03612431573844e-10 3.1374560110623e-08 1.3556274609177 0.584070796460177 1.1 1 1 reduced long term depression 0.000403786952835803 0.00503468694325344 1.35391581008321 0.583333333333333 1.1 1 1 abnormal trophoblast giant cell morphology 0.000403786952835803 0.00503468694325344 1.35391581008321 0.583333333333333 1.1 1 1 abnormal adrenal gland morphology 0.00376187052029121 0.0294729225802342 1.35391581008321 0.583333333333333 1.1 1 1 abnormal impulse conducting system conduction 0.00376187052029121 0.0294729225802342 1.35391581008321 0.583333333333333 1.1 1 1 increased hemangiosarcoma incidence 0.00376187052029121 0.0294729225802342 1.35391581008321 0.583333333333333 1.1 1 1 mesocardia 0.0393358597318841 0.157819275940422 1.35391581008321 0.583333333333333 1.1 1 1 abnormal superior cervical ganglion morphology 0.0393358597318841 0.157819275940422 1.35391581008321 0.583333333333333 1.1 1 1 abnormal mating frequency 0.0393358597318841 0.157819275940422 1.35391581008321 0.583333333333333 1.1 1 1 impaired embryo implantation 0.0393358597318841 0.157819275940422 1.35391581008321 0.583333333333333 1.1 1 1 abnormal embryonic growth/weight/body size 0.0393358597318841 0.157819275940422 1.35391581008321 0.583333333333333 1.1 1 1 altered tumor susceptibility 0.0393358597318841 0.157819275940422 1.35391581008321 0.583333333333333 1.1 1 1 abnormal respiratory function 0.0393358597318841 0.157819275940422 1.35391581008321 0.583333333333333 1.1 1 1 abnormal corticospinal tract morphology 0.0393358597318841 0.157819275940422 1.35391581008321 0.583333333333333 1.1 1 1 decreased synaptic depression 0.0393358597318841 0.157819275940422 1.35391581008321 0.583333333333333 1.1 1 1 abnormal aorta elastic fiber morphology 0.0393358597318841 0.157819275940422 1.35391581008321 0.583333333333333 1.1 1 1 loss of dopaminergic neurons 0.0393358597318841 0.157819275940422 1.35391581008321 0.583333333333333 1.1 1 1 abnormal vascular endothelial cell development 0.0393358597318841 0.157819275940422 1.35391581008321 0.583333333333333 1.1 1 1 abnormal defecation 0.0393358597318841 0.157819275940422 1.35391581008321 0.583333333333333 1.1 1 1 abnormal rostral-caudal body axis extension 0.0393358597318841 0.157819275940422 1.35391581008321 0.583333333333333 1.1 1 1 increased hepatocyte proliferation 0.0393358597318841 0.157819275940422 1.35391581008321 0.583333333333333 1.1 1 1 decreased renal glomerular filtration rate 0.0393358597318841 0.157819275940422 1.35391581008321 0.583333333333333 1.1 1 1 decreased keratinocyte proliferation 0.0393358597318841 0.157819275940422 1.35391581008321 0.583333333333333 1.1 1 1 impaired macrophage phagocytosis 0.000124456617557765 0.00199732797532219 1.3494177509135 0.581395348837209 1.1 1 1 lethality throughout fetal growth and development, incomplete penetrance 6.92268974728092e-15 1.23001362474009e-12 1.34851311331512 0.581005586592179 1.1 1 1 increased tumor incidence 9.59797738638677e-11 8.68180681768622e-09 1.34767656671877 0.580645161290323 1.1 1 1 abnormal cranial ganglia morphology 0.00112295426918878 0.0117614683983457 1.34767656671877 0.580645161290323 1.1 1 1 microcephaly 1.42734336208977e-06 4.67173238578725e-05 1.34550639511375 0.579710144927536 1.1 1 1 absent vitelline blood vessels 1.21630047023887e-05 0.000288147373306589 1.34373599196228 0.578947368421053 1.1 1 1 persistence of hyaloid vascular system 0.000342083105660654 0.00439757997587017 1.34373599196228 0.578947368421053 1.1 1 1 abnormal stationary movement 0.010840808511391 0.0633016694180401 1.34373599196228 0.578947368421053 1.1 1 1 abnormal neural crest cell migration 0.010840808511391 0.0633016694180401 1.34373599196228 0.578947368421053 1.1 1 1 increased liver cholesterol level 0.010840808511391 0.0633016694180401 1.34373599196228 0.578947368421053 1.1 1 1 increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 0.010840808511391 0.0633016694180401 1.34373599196228 0.578947368421053 1.1 1 1 decreased susceptibility to weight gain 0.010840808511391 0.0633016694180401 1.34373599196228 0.578947368421053 1.1 1 1 right-sided stomach 0.010840808511391 0.0633016694180401 1.34373599196228 0.578947368421053 1.1 1 1 small placenta 0.000105641069172073 0.00171753045467668 1.3410213737967 0.577777777777778 1.1 1 1 small liver 3.87609126154579e-07 1.40755868804309e-05 1.33903761436801 0.576923076923077 1.1 1 1 decreased kidney weight 3.29445986733307e-05 0.000668977054693145 1.33903761436801 0.576923076923077 1.1 1 1 abnormal kidney cortex morphology 0.00315652181807393 0.0259136898430986 1.33903761436801 0.576923076923077 1.1 1 1 abnormal ureter morphology 0.00315652181807393 0.0259136898430986 1.33903761436801 0.576923076923077 1.1 1 1 thick skin 0.00315652181807393 0.0259136898430986 1.33903761436801 0.576923076923077 1.1 1 1 abnormal erythrocyte osmotic lysis 0.00315652181807393 0.0259136898430986 1.33903761436801 0.576923076923077 1.1 1 1 pulmonary edema 0.00315652181807393 0.0259136898430986 1.33903761436801 0.576923076923077 1.1 1 1 decreased Peyer's patch number 0.00315652181807393 0.0259136898430986 1.33903761436801 0.576923076923077 1.1 1 1 abnormal skin morphology 3.26965645532597e-06 9.62517210961344e-05 1.33633248787434 0.575757575757576 1.1 1 1 increased osteoblast cell number 0.000946755564620326 0.0100858863682786 1.33633248787434 0.575757575757576 1.1 1 1 myeloid hyperplasia 0.000946755564620326 0.0100858863682786 1.33633248787434 0.575757575757576 1.1 1 1 abnormal cell nucleus morphology 8.95308396315055e-05 0.00150478353772547 1.33333958196644 0.574468085106383 1.1 1 1 abnormal nervous system physiology 1.12173029522357e-09 7.8600115756863e-08 1.33205133116261 0.573913043478261 1.1 1 1 abnormal dermal layer morphology 0.00079690235384653 0.00869427458418089 1.32628487518355 0.571428571428571 1.1 1 1 decreased glycogen level 0.00079690235384653 0.00869427458418089 1.32628487518355 0.571428571428571 1.1 1 1 increased bone resorption 0.00264394287705625 0.0226614430658477 1.32628487518355 0.571428571428571 1.1 1 1 decreased circulating progesterone level 0.00264394287705625 0.0226614430658477 1.32628487518355 0.571428571428571 1.1 1 1 increased triglyceride level 0.00264394287705625 0.0226614430658477 1.32628487518355 0.571428571428571 1.1 1 1 abnormal hematopoietic system physiology 0.00900587076447347 0.0560753530078292 1.32628487518355 0.571428571428571 1.1 1 1 liver degeneration 0.00900587076447347 0.0560753530078292 1.32628487518355 0.571428571428571 1.1 1 1 absent segment of posterior cerebral artery 0.00900587076447347 0.0560753530078292 1.32628487518355 0.571428571428571 1.1 1 1 megacephaly 0.0321343986224452 0.134225395588245 1.32628487518355 0.571428571428571 1.1 1 1 irregularly shaped pupil 0.0321343986224452 0.134225395588245 1.32628487518355 0.571428571428571 1.1 1 1 absent visceral yolk sac blood islands 0.0321343986224452 0.134225395588245 1.32628487518355 0.571428571428571 1.1 1 1 increased lactate dehydrogenase level 0.0321343986224452 0.134225395588245 1.32628487518355 0.571428571428571 1.1 1 1 enlarged stomach 0.0321343986224452 0.134225395588245 1.32628487518355 0.571428571428571 1.1 1 1 lysosomal protein accumulation 0.0321343986224452 0.134225395588245 1.32628487518355 0.571428571428571 1.1 1 1 abnormal glucose tolerance 0.0321343986224452 0.134225395588245 1.32628487518355 0.571428571428571 1.1 1 1 spina bifida occulta 0.0321343986224452 0.134225395588245 1.32628487518355 0.571428571428571 1.1 1 1 increased stomach tumor incidence 0.0321343986224452 0.134225395588245 1.32628487518355 0.571428571428571 1.1 1 1 increased lung compliance 0.0321343986224452 0.134225395588245 1.32628487518355 0.571428571428571 1.1 1 1 decreased compact bone area 0.0321343986224452 0.134225395588245 1.32628487518355 0.571428571428571 1.1 1 1 testis degeneration 0.0321343986224452 0.134225395588245 1.32628487518355 0.571428571428571 1.1 1 1 double outlet right ventricle 6.71062309384048e-09 3.92768822257134e-07 1.32318607874621 0.570093457943925 1.1 1 1 abnormal liver physiology 2.08920067758721e-08 1.06058911948943e-06 1.32296916299559 0.57 1.1 1 1 decreased B cell proliferation 6.38224062171754e-07 2.25188986475495e-05 1.32208777114816 0.569620253164557 1.1 1 1 abnormal cued conditioning behavior 6.40589582769579e-05 0.00115051739143634 1.31978347873658 0.568627450980392 1.1 1 1 decreased macrophage cell number 0.000206033037923659 0.00302364119076757 1.31874916566547 0.568181818181818 1.1 1 1 increased erythroid progenitor cell number 0.000669886336243939 0.00757930322426216 1.31732349089177 0.567567567567568 1.1 1 1 abnormal lactation 0.00221171499403287 0.0200059674460246 1.31523250122369 0.566666666666667 1.1 1 1 pallor 3.01658387850535e-13 4.54772872592852e-11 1.31302202643172 0.565714285714286 1.1 1 1 decreased spleen weight 4.54126218178735e-06 0.000126925726710068 1.31186873523591 0.565217391304348 1.1 1 1 abnormal vitelline vasculature morphology 3.50688963723827e-09 2.20845265129878e-07 1.31186873523591 0.565217391304348 1.1 1 1 abnormal myelin sheath morphology 0.000173580998436573 0.00263282154640838 1.31186873523591 0.565217391304348 1.1 1 1 atrial septal defect 0.000173580998436573 0.00263282154640838 1.31186873523591 0.565217391304348 1.1 1 1 abnormal cardiovascular development 0.00747410315996743 0.0499780419634919 1.31186873523591 0.565217391304348 1.1 1 1 decreased effector memory CD8-positive, alpha-beta T cell number 0.00747410315996743 0.0499780419634919 1.31186873523591 0.565217391304348 1.1 1 1 abnormal heart ventricle morphology 1.22157954444552e-06 4.0515721557443e-05 1.30928122293761 0.564102564102564 1.1 1 1 decreased trabecular bone volume 0.0005625138805382 0.00655387952149308 1.30928122293761 0.564102564102564 1.1 1 1 decreased liver weight 3.84157412884501e-06 0.000109838110867839 1.307604806519 0.563380281690141 1.1 1 1 vertebral transformation 0.000146108335248067 0.00228972647965938 1.30556167400881 0.5625 1.1 1 1 increased circulating follicle stimulating hormone level 0.00184834349416731 0.0171153901812462 1.30556167400881 0.5625 1.1 1 1 abnormal heart atrium morphology 0.00184834349416731 0.0171153901812462 1.30556167400881 0.5625 1.1 1 1 increased fatty acid level 0.00184834349416731 0.0171153901812462 1.30556167400881 0.5625 1.1 1 1 abnormal auditory brainstem response waveform shape 0.00184834349416731 0.0171153901812462 1.30556167400881 0.5625 1.1 1 1 absent mandible 0.0262700978922745 0.122797653292683 1.30556167400881 0.5625 1.1 1 1 vasculature congestion 0.0262700978922745 0.122797653292683 1.30556167400881 0.5625 1.1 1 1 mixed cellular infiltration to dermis 0.0262700978922745 0.122797653292683 1.30556167400881 0.5625 1.1 1 1 small pancreas 0.0262700978922745 0.122797653292683 1.30556167400881 0.5625 1.1 1 1 increased cochlear outer hair cell number 0.0262700978922745 0.122797653292683 1.30556167400881 0.5625 1.1 1 1 blepharitis 0.0262700978922745 0.122797653292683 1.30556167400881 0.5625 1.1 1 1 dystonia 0.0262700978922745 0.122797653292683 1.30556167400881 0.5625 1.1 1 1 increased heart left ventricle size 0.0262700978922745 0.122797653292683 1.30556167400881 0.5625 1.1 1 1 increased hepatocellular carcinoma incidence 3.84850496996204e-05 0.000762801283886899 1.30301671947858 0.56140350877193 1.1 1 1 liver fibrosis 0.000471939540661828 0.00564050901555058 1.30202356649117 0.560975609756098 1.1 1 1 hemopericardium 0.000471939540661828 0.00564050901555058 1.30202356649117 0.560975609756098 1.1 1 1 increased bone trabecula number 0.000471939540661828 0.00564050901555058 1.30202356649117 0.560975609756098 1.1 1 1 lethality at weaning, incomplete penetrance 0.000471939540661828 0.00564050901555058 1.30202356649117 0.560975609756098 1.1 1 1 respiratory distress 1.07990446887897e-12 1.40710954426649e-10 1.30136911885785 0.560693641618497 1.1 1 1 decreased erythrocyte cell number 1.21203130974853e-11 1.33996794799976e-09 1.30094185209087 0.560509554140127 1.1 1 1 small ovary 2.36584180733911e-07 8.84967142218954e-06 1.30077939681464 0.56043956043956 1.1 1 1 kyphosis 3.74233211683153e-11 3.79961271045651e-09 1.29975917767988 0.56 1.1 1 1 decreased heart rate 6.4229266103166e-08 2.75466033502803e-06 1.29975917767988 0.56 1.1 1 1 decreased oocyte number 0.000122888578463309 0.00197854588302576 1.29975917767988 0.56 1.1 1 1 ruffled hair 0.00619934098786816 0.0432003932122688 1.29975917767988 0.56 1.1 1 1 diaphragmatic hernia 0.00619934098786816 0.0432003932122688 1.29975917767988 0.56 1.1 1 1 impaired conditioned place preference behavior 0.00619934098786816 0.0432003932122688 1.29975917767988 0.56 1.1 1 1 ventricular septal defect 3.57277652764693e-10 2.86686503629733e-08 1.29702859117215 0.558823529411765 1.1 1 1 pericardial edema 8.63637985339575e-06 0.000221474174075484 1.29702859117215 0.558823529411765 1.1 1 1 decreased mean corpuscular hemoglobin 8.63637985339575e-06 0.000221474174075484 1.29702859117215 0.558823529411765 1.1 1 1 kidney failure 0.000395665595912868 0.00497079883754171 1.29544104087696 0.558139534883721 1.1 1 1 neonatal lethality, incomplete penetrance 5.9747505152493e-18 1.74849316549208e-15 1.29440302722241 0.557692307692308 1.1 1 1 increased susceptibility to injury 0.000103290107342401 0.00169593493078694 1.29440302722241 0.557692307692308 1.1 1 1 decreased circulating cholesterol level 4.72953057806707e-13 6.72268989310963e-11 1.29367131267904 0.557377049180328 1.1 1 1 impaired fertilization 7.28126329234244e-06 0.000192682366379807 1.29312775330396 0.557142857142857 1.1 1 1 abnormal response to infection 1.9549407221611e-06 6.11687427217073e-05 1.29270804290043 0.556962025316456 1.1 1 1 decreased bone mineral density 3.63218217039585e-18 1.29072187840853e-15 1.29138264162609 0.556390977443609 1.1 1 1 respiratory failure 5.94794568154808e-11 5.58321316333994e-09 1.29115150100651 0.556291390728477 1.1 1 1 irregular heartbeat 0.000331522998863142 0.00428396602427047 1.28944362865068 0.555555555555556 1.1 1 1 decreased circulating serum albumin level 1.2075709046429e-07 5.00638770883202e-06 1.28944362865068 0.555555555555556 1.1 1 1 abnormal osteoblast physiology 8.67673008443098e-05 0.00147298451912628 1.28944362865068 0.555555555555556 1.1 1 1 abnormal fetal cardiomyocyte proliferation 0.0051405001184846 0.0372256012947029 1.28944362865068 0.555555555555556 1.1 1 1 thick interventricular septum 0.0051405001184846 0.0372256012947029 1.28944362865068 0.555555555555556 1.1 1 1 delayed kidney development 0.0214979934763316 0.10738204572766 1.28944362865068 0.555555555555556 1.1 1 1 right pulmonary isomerism 0.0214979934763316 0.10738204572766 1.28944362865068 0.555555555555556 1.1 1 1 absent allantois 0.0214979934763316 0.10738204572766 1.28944362865068 0.555555555555556 1.1 1 1 abnormal eye anterior chamber morphology 0.0214979934763316 0.10738204572766 1.28944362865068 0.555555555555556 1.1 1 1 darkened coat color 0.0214979934763316 0.10738204572766 1.28944362865068 0.555555555555556 1.1 1 1 increased gastrointestinal tumor incidence 0.0214979934763316 0.10738204572766 1.28944362865068 0.555555555555556 1.1 1 1 abnormal hypoglossal nerve topology 0.0214979934763316 0.10738204572766 1.28944362865068 0.555555555555556 1.1 1 1 abnormal head movements 0.100150695859756 0.274064748021059 1.28944362865068 0.555555555555556 1.1 1 1 synostosis 0.100150695859756 0.274064748021059 1.28944362865068 0.555555555555556 1.1 1 1 absent parathyroid glands 0.100150695859756 0.274064748021059 1.28944362865068 0.555555555555556 1.1 1 1 abnormal sympathetic neuron morphology 0.100150695859756 0.274064748021059 1.28944362865068 0.555555555555556 1.1 1 1 abnormal vagina orifice morphology 0.100150695859756 0.274064748021059 1.28944362865068 0.555555555555556 1.1 1 1 multifocal hepatic necrosis 0.100150695859756 0.274064748021059 1.28944362865068 0.555555555555556 1.1 1 1 abnormal lung volume 0.100150695859756 0.274064748021059 1.28944362865068 0.555555555555556 1.1 1 1 abnormal gut-associated lymphoid tissue morphology 0.100150695859756 0.274064748021059 1.28944362865068 0.555555555555556 1.1 1 1 abnormal posterior semicircular canal morphology 0.100150695859756 0.274064748021059 1.28944362865068 0.555555555555556 1.1 1 1 abnormal NMDA-mediated synaptic currents 0.100150695859756 0.274064748021059 1.28944362865068 0.555555555555556 1.1 1 1 abnormal postural reflex 0.100150695859756 0.274064748021059 1.28944362865068 0.555555555555556 1.1 1 1 decreased circulating bicarbonate level 0.100150695859756 0.274064748021059 1.28944362865068 0.555555555555556 1.1 1 1 genetic imprinting 0.100150695859756 0.274064748021059 1.28944362865068 0.555555555555556 1.1 1 1 abnormal lens capsule morphology 0.100150695859756 0.274064748021059 1.28944362865068 0.555555555555556 1.1 1 1 abnormal abdominal wall morphology 0.100150695859756 0.274064748021059 1.28944362865068 0.555555555555556 1.1 1 1 premature bone ossification 0.100150695859756 0.274064748021059 1.28944362865068 0.555555555555556 1.1 1 1 decreased fear-related response 0.100150695859756 0.274064748021059 1.28944362865068 0.555555555555556 1.1 1 1 abnormal thymus physiology 0.100150695859756 0.274064748021059 1.28944362865068 0.555555555555556 1.1 1 1 abnormal posterior eye segment morphology 0.100150695859756 0.274064748021059 1.28944362865068 0.555555555555556 1.1 1 1 abnormal inguinal fat pad morphology 0.100150695859756 0.274064748021059 1.28944362865068 0.555555555555556 1.1 1 1 abnormal liver vasculature morphology 0.100150695859756 0.274064748021059 1.28944362865068 0.555555555555556 1.1 1 1 abnormal hyoid bone lesser horn morphology 0.100150695859756 0.274064748021059 1.28944362865068 0.555555555555556 1.1 1 1 abnormal hippocampus granule cell morphology 0.100150695859756 0.274064748021059 1.28944362865068 0.555555555555556 1.1 1 1 abnormal ventricle myocardium morphology 0.100150695859756 0.274064748021059 1.28944362865068 0.555555555555556 1.1 1 1 shortened ST segment 0.100150695859756 0.274064748021059 1.28944362865068 0.555555555555556 1.1 1 1 fusion of atlas and occipital bones 0.100150695859756 0.274064748021059 1.28944362865068 0.555555555555556 1.1 1 1 abnormal pulmonary alveolar system morphology 0.100150695859756 0.274064748021059 1.28944362865068 0.555555555555556 1.1 1 1 reduced AMPA-mediated synaptic currents 0.100150695859756 0.274064748021059 1.28944362865068 0.555555555555556 1.1 1 1 abnormal infrahyoid muscle connection 0.100150695859756 0.274064748021059 1.28944362865068 0.555555555555556 1.1 1 1 symmetric azygos veins 0.100150695859756 0.274064748021059 1.28944362865068 0.555555555555556 1.1 1 1 cerebellum atrophy 0.100150695859756 0.274064748021059 1.28944362865068 0.555555555555556 1.1 1 1 increased bone mineralization 0.100150695859756 0.274064748021059 1.28944362865068 0.555555555555556 1.1 1 1 decreased platelet dense granule number 0.100150695859756 0.274064748021059 1.28944362865068 0.555555555555556 1.1 1 1 small seminiferous tubules 5.16789223937574e-06 0.00014204565685577 1.28595864587054 0.554054054054054 1.1 1 1 abnormal bone mineralization 6.39406996981868e-09 3.8325901325118e-07 1.28518100508489 0.553719008264463 1.1 1 1 increased respiratory quotient 0.000277643099814276 0.00368608986724681 1.28395663448621 0.553191489361702 1.1 1 1 decreased bone trabecula number 0.000277643099814276 0.00368608986724681 1.28395663448621 0.553191489361702 1.1 1 1 decreased birth body size 1.97807800276085e-08 1.01452969729229e-06 1.28265708323673 0.552631578947368 1.1 1 1 increased bone marrow cell number 0.00107481973872917 0.0112810721522735 1.28265708323673 0.552631578947368 1.1 1 1 internal hemorrhage 1.62486513441239e-05 0.000369118906105098 1.28174545773336 0.552238805970149 1.1 1 1 decreased white adipose tissue amount 1.62486513441239e-05 0.000369118906105098 1.28174545773336 0.552238805970149 1.1 1 1 embryonic lethality during organogenesis, incomplete penetrance 1.85669381384082e-15 4.50465758976859e-13 1.28159484134585 0.552173913043478 1.1 1 1 enlarged spleen 5.77213444099761e-19 2.20895144953563e-16 1.28138460597161 0.552083333333333 1.1 1 1 dermatitis 6.11405982581924e-05 0.00111012582603835 1.28055091397033 0.551724137931034 1.1 1 1 abnormal cornea morphology 3.66174297552709e-06 0.000105301568226863 1.27952483150721 0.551282051282051 1.1 1 1 abnormal excitatory postsynaptic currents 3.66174297552709e-06 0.000105301568226863 1.27952483150721 0.551282051282051 1.1 1 1 organ of Corti degeneration 0.000232425774217898 0.0033323291836716 1.27891755821271 0.551020408163265 1.1 1 1 abnormal long bone hypertrophic chondrocyte zone 0.000232425774217898 0.0033323291836716 1.27891755821271 0.551020408163265 1.1 1 1 perimembraneous ventricular septal defect 1.36562015153673e-05 0.000317474778219403 1.27823107535806 0.550724637681159 1.1 1 1 anophthalmia 8.31423470192386e-07 2.84608335517355e-05 1.27785312412348 0.550561797752809 1.1 1 1 increased bone mineral content 5.16462611975403e-08 2.31477612124111e-06 1.27761387058966 0.55045871559633 1.1 1 1 intracranial hemorrhage 5.12930424671425e-05 0.000952174948783708 1.27654919236417 0.55 1.1 1 1 abnormal skin pigmentation 0.00089644628395753 0.00961168160062222 1.27654919236417 0.55 1.1 1 1 decreased myocardial infarction size 0.0176125887430093 0.0911785941690646 1.27654919236417 0.55 1.1 1 1 decreased circulating VLDL cholesterol level 0.0176125887430093 0.0911785941690646 1.27654919236417 0.55 1.1 1 1 abnormal sperm mitochondrial sheath morphology 0.0176125887430093 0.0911785941690646 1.27654919236417 0.55 1.1 1 1 increased skin tumor incidence 0.0176125887430093 0.0911785941690646 1.27654919236417 0.55 1.1 1 1 decreased IgG level 4.353682203943e-08 1.99681550186783e-06 1.27550369753013 0.54954954954955 1.1 1 1 increased grip strength 6.99997744576486e-07 2.43530683864896e-05 1.27527391844572 0.549450549450549 1.1 1 1 abnormal CD4-positive, alpha-beta T cell physiology 1.1473384460355e-05 0.000277087804321679 1.27491468635602 0.549295774647887 1.1 1 1 abnormal extraembryonic tissue morphology 1.59925982914638e-07 6.31453781746289e-06 1.27427370360773 0.549019607843137 1.1 1 1 abnormal dendritic spine morphology 0.000194507246516257 0.00290592658083598 1.27427370360773 0.549019607843137 1.1 1 1 hemorrhage 2.07052773388093e-15 4.57545964641498e-13 1.27408004499016 0.548936170212766 1.1 1 1 increased eosinophil cell number 4.30173874584943e-05 0.000826299237861039 1.27280564634551 0.548387096774194 1.1 1 1 pericardial effusion 4.30173874584943e-05 0.000826299237861039 1.27280564634551 0.548387096774194 1.1 1 1 abnormal intestine physiology 0.00353378158848641 0.0284015563856541 1.27280564634551 0.548387096774194 1.1 1 1 abnormal seminiferous tubule morphology 4.50608329132565e-10 3.39663096580986e-08 1.2717800172993 0.547945205479452 1.1 1 1 decreased bone marrow cell number 9.63645746438661e-06 0.000242128161036987 1.2717800172993 0.547945205479452 1.1 1 1 abnormal fertility/fecundity 9.63645746438661e-06 0.000242128161036987 1.2717800172993 0.547945205479452 1.1 1 1 skin edema 0.000747511495874482 0.00820942536859944 1.27102300538424 0.547619047619048 1.1 1 1 increased circulating bilirubin level 0.000162729452317271 0.00251422057539884 1.26998032859557 0.547169811320755 1.1 1 1 decreased lymphocyte cell number 5.9976551926879e-09 3.63882129068565e-07 1.26929607195301 0.546875 1.1 1 1 decreased circulating LDL cholesterol level 3.60665211890813e-05 0.000717723771662718 1.26929607195301 0.546875 1.1 1 1 decreased caudal vertebrae number 3.60665211890813e-05 0.000717723771662718 1.26929607195301 0.546875 1.1 1 1 abnormal neurocranium morphology 8.09134882654403e-06 0.000211033948830296 1.26881253059227 0.546666666666667 1.1 1 1 muscular atrophy 0.000623224665499917 0.00717718220106965 1.26599919903885 0.545454545454545 1.1 1 1 abnormal locomotor coordination 0.0029302490096237 0.024337210054888 1.26599919903885 0.545454545454545 1.1 1 1 abnormal T cell subpopulation ratio 0.0029302490096237 0.024337210054888 1.26599919903885 0.545454545454545 1.1 1 1 cardiovascular system phenotype 0.0029302490096237 0.024337210054888 1.26599919903885 0.545454545454545 1.1 1 1 abnormal long bone epiphysis morphology 0.0144457491094948 0.0771111607507902 1.26599919903885 0.545454545454545 1.1 1 1 aphakia 0.0144457491094948 0.0771111607507902 1.26599919903885 0.545454545454545 1.1 1 1 abnormal lysosome physiology 0.0144457491094948 0.0771111607507902 1.26599919903885 0.545454545454545 1.1 1 1 abnormal basement membrane morphology 0.0144457491094948 0.0771111607507902 1.26599919903885 0.545454545454545 1.1 1 1 cleft upper lip 0.0144457491094948 0.0771111607507902 1.26599919903885 0.545454545454545 1.1 1 1 abnormal mesenteric lymph node morphology 0.0144457491094948 0.0771111607507902 1.26599919903885 0.545454545454545 1.1 1 1 abnormal cerebral cortex pyramidal cell morphology 0.0144457491094948 0.0771111607507902 1.26599919903885 0.545454545454545 1.1 1 1 increased mast cell number 0.0794594106954205 0.256862964844569 1.26599919903885 0.545454545454545 1.1 1 1 abnormal large intestine morphology 0.0794594106954205 0.256862964844569 1.26599919903885 0.545454545454545 1.1 1 1 abnormal sebaceous gland morphology 0.0794594106954205 0.256862964844569 1.26599919903885 0.545454545454545 1.1 1 1 social withdrawal 0.0794594106954205 0.256862964844569 1.26599919903885 0.545454545454545 1.1 1 1 failure of somite differentiation 0.0794594106954205 0.256862964844569 1.26599919903885 0.545454545454545 1.1 1 1 retinal detachment 0.0794594106954205 0.256862964844569 1.26599919903885 0.545454545454545 1.1 1 1 rectal hemorrhage 0.0794594106954205 0.256862964844569 1.26599919903885 0.545454545454545 1.1 1 1 abnormal coronal suture morphology 0.0794594106954205 0.256862964844569 1.26599919903885 0.545454545454545 1.1 1 1 enlarged placenta 0.0794594106954205 0.256862964844569 1.26599919903885 0.545454545454545 1.1 1 1 abnormal spinal cord ventral horn morphology 0.0794594106954205 0.256862964844569 1.26599919903885 0.545454545454545 1.1 1 1 increased glycogen level 0.0794594106954205 0.256862964844569 1.26599919903885 0.545454545454545 1.1 1 1 increased circulating triiodothyronine level 0.0794594106954205 0.256862964844569 1.26599919903885 0.545454545454545 1.1 1 1 enhanced behavioral response to addictive substance 0.0794594106954205 0.256862964844569 1.26599919903885 0.545454545454545 1.1 1 1 palatal shelf hypoplasia 0.0794594106954205 0.256862964844569 1.26599919903885 0.545454545454545 1.1 1 1 decreased core body temperature 0.0794594106954205 0.256862964844569 1.26599919903885 0.545454545454545 1.1 1 1 decreased embryonic cilium length 0.0794594106954205 0.256862964844569 1.26599919903885 0.545454545454545 1.1 1 1 hypolactation 0.0794594106954205 0.256862964844569 1.26599919903885 0.545454545454545 1.1 1 1 thin hypoglossal nerve 0.0794594106954205 0.256862964844569 1.26599919903885 0.545454545454545 1.1 1 1 increased leukocyte cell number 8.28179079718123e-10 5.97129119072125e-08 1.2645440275457 0.544827586206897 1.1 1 1 increased blood urea nitrogen level 8.28179079718123e-10 5.97129119072125e-08 1.2645440275457 0.544827586206897 1.1 1 1 decreased circulating glucose level 1.72291821975204e-17 4.7619545240369e-15 1.26448665519292 0.544802867383513 1.1 1 1 abnormal nervous system morphology 5.70042344482537e-06 0.000152471003430141 1.26332831465269 0.544303797468354 1.1 1 1 abnormal blood homeostasis 5.68526656979408e-08 2.52537510577906e-06 1.26229744699487 0.543859649122807 1.1 1 1 increased macrophage cell number 0.000113826316690308 0.00183859066731909 1.26229744699487 0.543859649122807 1.1 1 1 abnormal sleep pattern 0.000519549189847149 0.00612501710779518 1.26141224541914 0.543478260869565 1.1 1 1 embryonic lethality between implantation and placentation, complete penetrance 0.000519549189847149 0.00612501710779518 1.26141224541914 0.543478260869565 1.1 1 1 abnormal neural tube morphology 1.14553531512683e-10 1.01768539156357e-08 1.26078932579177 0.54320987654321 1.1 1 1 ovary cysts 0.00243017616524962 0.0217057924993121 1.25997063142438 0.542857142857143 1.1 1 1 increased red blood cell distribution width 0.00243017616524962 0.0217057924993121 1.25997063142438 0.542857142857143 1.1 1 1 impaired adaptive thermogenesis 0.00243017616524962 0.0217057924993121 1.25997063142438 0.542857142857143 1.1 1 1 abnormal neural tube closure 4.01264001570008e-06 0.000114073623303474 1.25837269783982 0.542168674698795 1.1 1 1 abnormal forebrain development 1.7781617789613e-05 0.000396697526920739 1.25720753793441 0.541666666666667 1.1 1 1 small lymph nodes 0.0118612871886757 0.0654937888608895 1.25720753793441 0.541666666666667 1.1 1 1 abnormal tumor morphology 0.0118612871886757 0.0654937888608895 1.25720753793441 0.541666666666667 1.1 1 1 abnormal retinal ganglion layer morphology 0.0118612871886757 0.0654937888608895 1.25720753793441 0.541666666666667 1.1 1 1 abnormal lung saccule morphology 0.0118612871886757 0.0654937888608895 1.25720753793441 0.541666666666667 1.1 1 1 abnormal cardiovascular system physiology 6.55113082133289e-09 3.87998521858704e-07 1.25648040806863 0.541353383458647 1.1 1 1 decreased hematocrit 1.27337444234887e-09 8.67813404203514e-08 1.25588276708306 0.541095890410959 1.1 1 1 embryonic lethality during organogenesis, complete penetrance 9.747661912978e-33 1.21236545042664e-29 1.25582599118943 0.541071428571429 1.1 1 1 abnormal long bone morphology 7.9568631448464e-05 0.00139877717829014 1.25562215642377 0.540983606557377 1.1 1 1 abnormal intestine morphology 1.4893593023223e-05 0.000344630815304812 1.25459380084931 0.540540540540541 1.1 1 1 abnormal breathing pattern 0.00201583809789349 0.0185033109539116 1.25459380084931 0.540540540540541 1.1 1 1 abnormal calcium ion homeostasis 0.00201583809789349 0.0185033109539116 1.25459380084931 0.540540540540541 1.1 1 1 anemia 3.6212834247545e-13 5.29878971710401e-11 1.2539992066309 0.540284360189573 1.1 1 1 kidney inflammation 0.000361012917060243 0.00461706751253138 1.25333920704846 0.54 1.1 1 1 abnormal eye morphology 3.89386976678268e-09 2.42150026121798e-07 1.25233733717872 0.539568345323741 1.1 1 1 abnormal testis morphology 8.71968170636692e-08 3.67630648213351e-06 1.25132094745579 0.539130434782609 1.1 1 1 decreased circulating HDL cholesterol level 1.68646146685027e-08 8.83173241850538e-07 1.25116327092511 0.5390625 1.1 1 1 increased insulin sensitivity 2.75084291120515e-09 1.77733032249943e-07 1.24976844007681 0.538461538461538 1.1 1 1 distended pericardium 0.000300927242219089 0.00395016630617405 1.24976844007681 0.538461538461538 1.1 1 1 abnormal brain wave pattern 0.000300927242219089 0.00395016630617405 1.24976844007681 0.538461538461538 1.1 1 1 increased vascular permeability 0.00167250990661865 0.0162197598156487 1.24976844007681 0.538461538461538 1.1 1 1 decreased B-1 B cell number 0.00167250990661865 0.0162197598156487 1.24976844007681 0.538461538461538 1.1 1 1 abnormal Mullerian duct morphology 0.0097492966859614 0.0591496963568999 1.24976844007681 0.538461538461538 1.1 1 1 decreased bone resorption 0.0097492966859614 0.0591496963568999 1.24976844007681 0.538461538461538 1.1 1 1 short premaxilla 0.0634937585161931 0.222451724378916 1.24976844007681 0.538461538461538 1.1 1 1 absent teeth 0.0634937585161931 0.222451724378916 1.24976844007681 0.538461538461538 1.1 1 1 abnormal renal/urinary system morphology 0.0634937585161931 0.222451724378916 1.24976844007681 0.538461538461538 1.1 1 1 small trigeminal ganglion 0.0634937585161931 0.222451724378916 1.24976844007681 0.538461538461538 1.1 1 1 abnormal grip strength 0.0634937585161931 0.222451724378916 1.24976844007681 0.538461538461538 1.1 1 1 abnormal pulmonary alveolus epithelial cell morphology 0.0634937585161931 0.222451724378916 1.24976844007681 0.538461538461538 1.1 1 1 dystrophic cardiac calcinosis 0.0634937585161931 0.222451724378916 1.24976844007681 0.538461538461538 1.1 1 1 abnormal tail bud morphology 0.0634937585161931 0.222451724378916 1.24976844007681 0.538461538461538 1.1 1 1 abnormal telomere length 0.0634937585161931 0.222451724378916 1.24976844007681 0.538461538461538 1.1 1 1 axonal dystrophy 0.0634937585161931 0.222451724378916 1.24976844007681 0.538461538461538 1.1 1 1 abnormal vestibulocochlear ganglion morphology 0.0634937585161931 0.222451724378916 1.24976844007681 0.538461538461538 1.1 1 1 increased circulating thyroid-stimulating hormone level 0.0634937585161931 0.222451724378916 1.24976844007681 0.538461538461538 1.1 1 1 abnormal vertebral arch development 0.0634937585161931 0.222451724378916 1.24976844007681 0.538461538461538 1.1 1 1 increased circulating thyroxine level 0.0634937585161931 0.222451724378916 1.24976844007681 0.538461538461538 1.1 1 1 increased circulating triglyceride level 2.31168052534342e-09 1.5334147484778e-07 1.24853714112107 0.537931034482759 1.1 1 1 thrombocytopenia 2.31168052534342e-09 1.5334147484778e-07 1.24853714112107 0.537931034482759 1.1 1 1 abnormal lung morphology 6.14776762603718e-08 2.67622396725826e-06 1.24826811781982 0.53781512605042 1.1 1 1 hypoglycemia 1.66355374267043e-06 5.27145214636012e-05 1.24784867288775 0.537634408602151 1.1 1 1 maternal effect 4.6468873898715e-05 0.000869107697917695 1.24710368860543 0.537313432835821 1.1 1 1 abnormal neuronal precursor proliferation 0.000250845548025908 0.00353528782274473 1.24646217436232 0.537037037037037 1.1 1 1 axon degeneration 0.000250845548025908 0.00353528782274473 1.24646217436232 0.537037037037037 1.1 1 1 abnormal coat/hair pigmentation 1.88253702842209e-07 7.26017187317822e-06 1.24339207048458 0.535714285714286 1.1 1 1 abnormal circulating cholesterol level 0.00802114308936341 0.0522797245773669 1.24339207048458 0.535714285714286 1.1 1 1 lymphoid hyperplasia 0.00802114308936341 0.0522797245773669 1.24339207048458 0.535714285714286 1.1 1 1 abnormal ovulation 0.00802114308936341 0.0522797245773669 1.24339207048458 0.535714285714286 1.1 1 1 hypoxia 0.00802114308936341 0.0522797245773669 1.24339207048458 0.535714285714286 1.1 1 1 increased circulating free fatty acid level 3.24572326371629e-05 0.000661781690040514 1.24222456619305 0.535211267605634 1.1 1 1 abnormal cell morphology 1.57890262475098e-07 6.28403244650891e-06 1.24193781075302 0.535087719298246 1.1 1 1 abnormal organ of Corti morphology 0.00115213428083034 0.0120164948577169 1.24146433084042 0.534883720930233 1.1 1 1 decreased oxygen consumption 0.00115213428083034 0.0120164948577169 1.24146433084042 0.534883720930233 1.1 1 1 decreased bone mineral content 2.12804890738267e-12 2.6467608285572e-10 1.23860979329041 0.533653846153846 1.1 1 1 delayed bone ossification 2.26675863908562e-05 0.000490309749106564 1.23786588350465 0.533333333333333 1.1 1 1 spleen hyperplasia 2.26675863908562e-05 0.000490309749106564 1.23786588350465 0.533333333333333 1.1 1 1 increased circulating corticosterone level 0.000956597998799094 0.0101472815437644 1.23786588350465 0.533333333333333 1.1 1 1 abnormal cell migration 0.000956597998799094 0.0101472815437644 1.23786588350465 0.533333333333333 1.1 1 1 liver inflammation 9.31041393901775e-08 3.89237893669019e-06 1.23786588350465 0.533333333333333 1.1 1 1 abnormal kidney development 0.000145324717343257 0.00228972647965938 1.23786588350465 0.533333333333333 1.1 1 1 disorganized myocardium 0.0066052952619423 0.045263559129701 1.23786588350465 0.533333333333333 1.1 1 1 abnormal spleen marginal zone morphology 0.0066052952619423 0.045263559129701 1.23786588350465 0.533333333333333 1.1 1 1 abnormal synaptic transmission 0.0066052952619423 0.045263559129701 1.23786588350465 0.533333333333333 1.1 1 1 macrocytosis 0.0510147493033876 0.190539322660926 1.23786588350465 0.533333333333333 1.1 1 1 abnormal epidermis stratum spinosum morphology 0.0510147493033876 0.190539322660926 1.23786588350465 0.533333333333333 1.1 1 1 no suckling reflex 0.0510147493033876 0.190539322660926 1.23786588350465 0.533333333333333 1.1 1 1 abnormal ear development 0.0510147493033876 0.190539322660926 1.23786588350465 0.533333333333333 1.1 1 1 abnormal placenta size 0.0510147493033876 0.190539322660926 1.23786588350465 0.533333333333333 1.1 1 1 abnormal dendritic cell morphology 0.0510147493033876 0.190539322660926 1.23786588350465 0.533333333333333 1.1 1 1 decreased thymocyte apoptosis 0.0510147493033876 0.190539322660926 1.23786588350465 0.533333333333333 1.1 1 1 liver vascular congestion 0.0510147493033876 0.190539322660926 1.23786588350465 0.533333333333333 1.1 1 1 decreased leukocyte cell number 1.26893517641265e-08 6.93731044247576e-07 1.23673644382992 0.532846715328467 1.1 1 1 embryonic growth arrest 2.07431438193517e-13 3.22491064066484e-11 1.23651450153576 0.532751091703057 1.1 1 1 abnormal heart development 1.223440547977e-09 8.45363434192443e-08 1.23394858640495 0.531645569620253 1.1 1 1 abnormal placenta labyrinth morphology 1.58297082693242e-05 0.000363229577486227 1.23394858640495 0.531645569620253 1.1 1 1 weight loss 1.68185577601957e-10 1.41817499757582e-08 1.2334449339207 0.531428571428571 1.1 1 1 decreased embryo size 4.1867394037335e-26 2.60362856669677e-23 1.23333394773868 0.531380753138075 1.1 1 1 abnormal diaphragm morphology 0.00544394476204805 0.0389692448794087 1.23303046989721 0.53125 1.1 1 1 abnormal depression-related behavior 0.00544394476204805 0.0389692448794087 1.23303046989721 0.53125 1.1 1 1 increased exploration in new environment 1.32282950256503e-05 0.000308970740622583 1.23213502293287 0.530864197530864 1.1 1 1 abnormal liver morphology 1.18430209330996e-10 1.03366717793282e-08 1.23181486312439 0.53072625698324 1.1 1 1 cardiac hypertrophy 1.76316702114341e-06 5.55174425961295e-05 1.23155024124187 0.530612244897959 1.1 1 1 enlarged liver 1.47545689659028e-06 4.79764579120041e-05 1.23012922173275 0.53 1.1 1 1 decreased neutrophil cell number 1.99137124086358e-07 7.62082455638176e-06 1.22993084578988 0.52991452991453 1.1 1 1 prenatal lethality, incomplete penetrance 6.69896532545464e-17 1.75407118390194e-14 1.22921303810186 0.529605263157895 1.1 1 1 cardiac fibrosis 9.23784393234498e-06 0.000235683454171365 1.22876392847888 0.529411764705882 1.1 1 1 lung inflammation 2.26980077107066e-08 1.11804542931451e-06 1.22876392847888 0.529411764705882 1.1 1 1 abnormal oocyte morphology 0.00449029460865142 0.0329973643693365 1.22876392847888 0.529411764705882 1.1 1 1 thin skin 0.00449029460865142 0.0329973643693365 1.22876392847888 0.529411764705882 1.1 1 1 impaired synaptic plasticity 0.00449029460865142 0.0329973643693365 1.22876392847888 0.529411764705882 1.1 1 1 abnormal bone marrow cavity morphology 0.0411673880275365 0.162541122551513 1.22876392847888 0.529411764705882 1.1 1 1 abnormal interatrial septum morphology 0.0411673880275365 0.162541122551513 1.22876392847888 0.529411764705882 1.1 1 1 hydroureter 0.0411673880275365 0.162541122551513 1.22876392847888 0.529411764705882 1.1 1 1 abnormal cranial suture morphology 0.0411673880275365 0.162541122551513 1.22876392847888 0.529411764705882 1.1 1 1 abnormal glutamate-mediated receptor currents 0.0411673880275365 0.162541122551513 1.22876392847888 0.529411764705882 1.1 1 1 abnormal embryonic-extraembryonic boundary morphology 0.0411673880275365 0.162541122551513 1.22876392847888 0.529411764705882 1.1 1 1 abnormal tendon morphology 0.0411673880275365 0.162541122551513 1.22876392847888 0.529411764705882 1.1 1 1 abnormal placenta development 0.000455708766909125 0.00554315676130293 1.22618790347159 0.528301886792453 1.1 1 1 abnormal muscle physiology 6.45140660908213e-06 0.000171635015402051 1.22569585375109 0.528089887640449 1.1 1 1 abnormal lysosome morphology 0.00370639449717041 0.0294729225802342 1.22497144721814 0.527777777777778 1.1 1 1 abnormal B cell differentiation 5.39145281415954e-06 0.000147136870951291 1.2242629617079 0.527472527472527 1.1 1 1 female infertility 1.3179685302731e-14 2.18563114603623e-12 1.22157817451117 0.526315789473684 1.1 1 1 abnormal craniofacial bone morphology 0.000314970061159675 0.00409370522517309 1.22157817451117 0.526315789473684 1.1 1 1 enlarged adrenal glands 0.0333393101040433 0.137190295920277 1.22157817451117 0.526315789473684 1.1 1 1 small superior vagus ganglion 0.0333393101040433 0.137190295920277 1.22157817451117 0.526315789473684 1.1 1 1 flaky skin 0.0333393101040433 0.137190295920277 1.22157817451117 0.526315789473684 1.1 1 1 stereotypic behavior 0.0333393101040433 0.137190295920277 1.22157817451117 0.526315789473684 1.1 1 1 delayed sexual maturation 0.0333393101040433 0.137190295920277 1.22157817451117 0.526315789473684 1.1 1 1 decreased tumor incidence 0.0333393101040433 0.137190295920277 1.22157817451117 0.526315789473684 1.1 1 1 increased liver adenoma incidence 0.0333393101040433 0.137190295920277 1.22157817451117 0.526315789473684 1.1 1 1 abnormal photoreceptor inner segment morphology 0.0333393101040433 0.137190295920277 1.22157817451117 0.526315789473684 1.1 1 1 increased left ventricle weight 0.0333393101040433 0.137190295920277 1.22157817451117 0.526315789473684 1.1 1 1 abnormal blastocyst morphology 0.0333393101040433 0.137190295920277 1.22157817451117 0.526315789473684 1.1 1 1 decreased fertilization frequency 0.0333393101040433 0.137190295920277 1.22157817451117 0.526315789473684 1.1 1 1 reduced female fertility 6.89775990462668e-13 9.27469068257237e-11 1.22052508987797 0.525862068965517 1.1 1 1 increased mean corpuscular hemoglobin 2.63023417248811e-06 7.93055455038082e-05 1.21911033981519 0.525252525252525 1.1 1 1 prenatal lethality, complete penetrance 4.57907789670028e-15 8.76188943695534e-13 1.21894167485395 0.525179856115108 1.1 1 1 decreased circulating phosphate level 0.00253026443692828 0.0219687008267334 1.21852422907489 0.525 1.1 1 1 impaired ovarian folliculogenesis 0.00253026443692828 0.0219687008267334 1.21852422907489 0.525 1.1 1 1 abnormal pulmonary alveolus morphology 2.1983164942471e-06 6.70958561894438e-05 1.21794972448787 0.524752475247525 1.1 1 1 abnormal maternal nurturing 0.000217883156951303 0.00317879385874701 1.21757300016851 0.524590163934426 1.1 1 1 sparse hair 1.97409958561799e-05 0.000436487419622462 1.21710898606783 0.524390243902439 1.1 1 1 arrest of spermatogenesis 1.64723051332748e-05 0.000372498718354738 1.21576113558492 0.523809523809524 1.1 1 1 abnormal stapes morphology 0.0270799785193987 0.122797653292683 1.21576113558492 0.523809523809524 1.1 1 1 embryonic lethality at implantation, complete penetrance 0.0270799785193987 0.122797653292683 1.21576113558492 0.523809523809524 1.1 1 1 increased muscle cell glucose uptake 0.0270799785193987 0.122797653292683 1.21576113558492 0.523809523809524 1.1 1 1 infertility 1.28363069254409e-06 4.22918059298465e-05 1.21472820343914 0.523364485981308 1.1 1 1 increased T cell number 1.14715752375596e-05 0.000277087804321679 1.21324923241223 0.522727272727273 1.1 1 1 abnormal gametogenesis 0.00173141624047795 0.0163523590701601 1.21324923241223 0.522727272727273 1.1 1 1 renal interstitial fibrosis 0.00173141624047795 0.0163523590701601 1.21324923241223 0.522727272727273 1.1 1 1 abnormal cranium morphology 7.12621950650279e-08 3.03016598673944e-06 1.2124619194775 0.522388059701492 1.1 1 1 oxidative stress 9.57426235271194e-06 0.000242128161036987 1.21207701093164 0.522222222222222 1.1 1 1 perinatal lethality, incomplete penetrance 3.0460905063084e-12 3.60816673068673e-10 1.21184879082037 0.52212389380531 1.1 1 1 abnormal cell cycle 6.26697335759178e-07 2.22701374671565e-05 1.21095575560238 0.521739130434783 1.1 1 1 abnormal sternum morphology 0.000104508887058373 0.00171030168787962 1.21095575560238 0.521739130434783 1.1 1 1 abnormal pulmonary artery morphology 0.0220511810544337 0.108209565713272 1.21095575560237 0.521739130434783 1.1 1 1 abnormal cranial nerve morphology 0.0220511810544337 0.108209565713272 1.21095575560237 0.521739130434783 1.1 1 1 abnormal Wolffian duct morphology 0.0220511810544337 0.108209565713272 1.21095575560237 0.521739130434783 1.1 1 1 dilated heart 0.0220511810544337 0.108209565713272 1.21095575560237 0.521739130434783 1.1 1 1 abnormal basicranium morphology 0.0220511810544337 0.108209565713272 1.21095575560237 0.521739130434783 1.1 1 1 abnormal ovary morphology 8.70123757904919e-05 0.00147298451912628 1.20953444603007 0.52112676056338 1.1 1 1 atelectasis 8.70123757904919e-05 0.00147298451912628 1.20953444603007 0.52112676056338 1.1 1 1 corneal opacity 8.70123757904919e-05 0.00147298451912628 1.20953444603007 0.52112676056338 1.1 1 1 cyanosis 1.59401375840915e-10 1.36727904277336e-08 1.20885340186001 0.520833333333333 1.1 1 1 abnormal osteoclast morphology 0.00118721334120979 0.0122235738876698 1.20885340186001 0.520833333333333 1.1 1 1 seminiferous tubule degeneration 7.24571674003155e-05 0.00128740859934489 1.20819101643433 0.520547945205479 1.1 1 1 spontaneous skin ulceration 0.0179950622395505 0.0928687081346099 1.20691923641703 0.52 1.1 1 1 abnormal nest building behavior 0.0179950622395505 0.0928687081346099 1.20691923641703 0.52 1.1 1 1 abnormal vertebrae development 0.0179950622395505 0.0928687081346099 1.20691923641703 0.52 1.1 1 1 abnormal leukocyte migration 0.000815528714961624 0.00882548596086975 1.20513385293121 0.519230769230769 1.1 1 1 increased neuron apoptosis 3.48944047482117e-05 0.000705689689521761 1.20348072007397 0.518518518518518 1.1 1 1 abnormal chondrocyte morphology 0.000676330694937205 0.00757930322426216 1.20348072007397 0.518518518518518 1.1 1 1 increased cell proliferation 0.000676330694937205 0.00757930322426216 1.20348072007397 0.518518518518518 1.1 1 1 diluted coat color 0.000676330694937205 0.00757930322426216 1.20348072007397 0.518518518518518 1.1 1 1 abnormal cell adhesion 0.000676330694937205 0.00757930322426216 1.20348072007397 0.518518518518518 1.1 1 1 decreased circulating fructosamine level 0.0147126160663211 0.0784515165379929 1.20348072007397 0.518518518518518 1.1 1 1 postnatal lethality, incomplete penetrance 1.67202860940841e-27 1.18833461882955e-24 1.20136191598933 0.517605633802817 1.1 1 1 glomerulosclerosis 0.000465669419464331 0.00563675270519476 1.20051648184718 0.517241379310345 1.1 1 1 abnormal middle ear morphology 0.0120487402004057 0.0658708598868335 1.20051648184718 0.517241379310345 1.1 1 1 abnormal parietal bone morphology 0.0120487402004057 0.0658708598868335 1.20051648184718 0.517241379310345 1.1 1 1 abnormal microglial cell morphology 0.0120487402004057 0.0658708598868335 1.20051648184718 0.517241379310345 1.1 1 1 decreased granulocyte number 0.0120487402004057 0.0658708598868335 1.20051648184718 0.517241379310345 1.1 1 1 abnormal spinal nerve morphology 0.0120487402004057 0.0658708598868335 1.20051648184718 0.517241379310345 1.1 1 1 abnormal outer ear morphology 0.0120487402004057 0.0658708598868335 1.20051648184718 0.517241379310345 1.1 1 1 abnormal embryonic erythropoiesis 0.0120487402004057 0.0658708598868335 1.20051648184718 0.517241379310345 1.1 1 1 increased double-positive T cell number 0.0120487402004057 0.0658708598868335 1.20051648184718 0.517241379310345 1.1 1 1 abnormal spermatogenesis 8.26986355116893e-10 5.97129119072125e-08 1.19834163314818 0.516304347826087 1.1 1 1 impaired glucose tolerance 1.10306074826921e-12 1.40710954426649e-10 1.19793472597224 0.516129032258065 1.1 1 1 abnormal definitive hematopoiesis 1.17092949067873e-05 0.000281419044257327 1.19793472597224 0.516129032258065 1.1 1 1 abnormal capillary morphology 0.00988157651362854 0.0597337097877302 1.19793472597224 0.516129032258065 1.1 1 1 small cranium 0.00988157651362854 0.0597337097877302 1.19793472597224 0.516129032258065 1.1 1 1 preaxial polydactyly 0.00988157651362854 0.0597337097877302 1.19793472597224 0.516129032258065 1.1 1 1 impaired righting response 9.76500428507511e-06 0.000244125107126878 1.19714661102094 0.515789473684211 1.1 1 1 abnormal myocardial fiber morphology 8.1444257639029e-06 0.000211033948830296 1.19639099565527 0.515463917525773 1.1 1 1 abnormal tail morphology 0.000221612960621968 0.00322375578682542 1.19566591020336 0.515151515151515 1.1 1 1 increased cardiomyocyte apoptosis 0.00811474649899895 0.0522797245773669 1.19566591020336 0.515151515151515 1.1 1 1 decreased circulating alanine transaminase level 0.000184196951400066 0.00278534903712866 1.19463159713224 0.514705882352941 1.1 1 1 thymus hypoplasia 1.27199710894988e-07 5.18193099283665e-06 1.19413692566345 0.514492753623188 1.1 1 1 abnormal kidney morphology 2.92759283302617e-09 1.86727876209041e-07 1.1936563876652 0.514285714285714 1.1 1 1 thick pulmonary interalveolar septum 0.0066715964899004 0.0454051881494589 1.1936563876652 0.514285714285714 1.1 1 1 abnormal intestinal goblet cell morphology 0.0066715964899004 0.0454051881494589 1.1936563876652 0.514285714285714 1.1 1 1 abnormal midbrain development 0.0066715964899004 0.0454051881494589 1.1936563876652 0.514285714285714 1.1 1 1 decreased triglyceride level 0.0066715964899004 0.0454051881494589 1.1936563876652 0.514285714285714 1.1 1 1 decreased bone volume 0.0066715964899004 0.0454051881494589 1.1936563876652 0.514285714285714 1.1 1 1 abnormal digit morphology 0.000127345531766316 0.00203058980941482 1.19273535650188 0.513888888888889 1.1 1 1 increased susceptibility to bacterial infection induced morbidity/mortality 0.000127345531766316 0.00203058980941482 1.19273535650188 0.513888888888889 1.1 1 1 abnormal pancreatic beta cell physiology 0.00549087069640718 0.039192369748387 1.19186411080684 0.513513513513513 1.1 1 1 abnormal chromosome morphology 0.00549087069640718 0.039192369748387 1.19186411080684 0.513513513513513 1.1 1 1 abnormal retinal pigment epithelium morphology 6.10311638067506e-05 0.00111012582603835 1.18951174743025 0.5125 1.1 1 1 decreased anxiety-related response 7.7597705741629e-07 2.68089295878197e-05 1.18880412592672 0.51219512195122 1.1 1 1 thin ventricular wall 2.44400651995705e-05 0.000519612497298561 1.18628813835862 0.511111111111111 1.1 1 1 decreased insulin secretion 2.44400651995705e-05 0.000519612497298561 1.18628813835862 0.511111111111111 1.1 1 1 abnormal ectoderm development 0.0025414534931422 0.0219890976145782 1.18628813835862 0.511111111111111 1.1 1 1 abnormal myocardial trabeculae morphology 0.0025414534931422 0.0219890976145782 1.18628813835862 0.511111111111111 1.1 1 1 abnormal locomotor behavior 2.036213352139e-05 0.000445167999424544 1.18572751069399 0.510869565217391 1.1 1 1 increased anxiety-related response 1.83685259007147e-07 7.13932940281686e-06 1.18554601252918 0.510791366906475 1.1 1 1 increased monocyte cell number 9.82461188521915e-06 0.000244387220644826 1.18370925110132 0.51 1.1 1 1 small lung 0.00143661928505554 0.0143517689621512 1.18325415335003 0.509803921568627 1.1 1 1 decreased B cell number 2.89016649681804e-10 2.35714398715898e-08 1.18303323211154 0.509708737864078 1.1 1 1 abnormal mesoderm development 0.00118918789178536 0.0122235738876698 1.1823954783476 0.509433962264151 1.1 1 1 abnormal brain morphology 2.54574475903692e-08 1.24167452707928e-06 1.18212347570708 0.509316770186335 1.1 1 1 short snout 4.74973013081418e-06 0.000131277263337781 1.18198999292979 0.509259259259259 1.1 1 1 abnormal head morphology 0.000984862677310342 0.0104027427168131 1.18159925243626 0.509090909090909 1.1 1 1 decreased susceptibility to induced arthritis 0.000816023975130203 0.00882548596086975 1.18085890202746 0.508771929824561 1.1 1 1 premature death 4.61469010759347e-38 7.65269442842584e-35 1.18071702302926 0.508710801393728 1.1 1 1 enlarged heart 2.83200329235046e-11 2.93525341238407e-09 1.1805078738164 0.508620689655172 1.1 1 1 abnormal thoracic vertebrae morphology 0.000676424247552241 0.00757930322426216 1.18016874486672 0.508474576271186 1.1 1 1 increased B cell proliferation 0.000676424247552241 0.00757930322426216 1.18016874486672 0.508474576271186 1.1 1 1 decreased susceptibility to hepatic steatosis 0.000465342104783324 0.00563675270519476 1.17891988905205 0.507936507936508 1.1 1 1 decreased T cell proliferation 1.28116082837971e-07 5.18193099283665e-06 1.17618168829623 0.506756756756757 1.1 1 1 abnormal somite development 0.000105585796996755 0.00171753045467668 1.17518912990948 0.506329113924051 1.1 1 1 embryonic lethality between implantation and somite formation, complete penetrance 1.38290296485282e-11 1.49563961959625e-09 1.17470946087686 0.506122448979592 1.1 1 1 abnormal lipid level 7.30618127190142e-05 0.00128894510027339 1.1744811846505 0.506024096385542 1.1 1 1 increased startle reflex 4.21203496102136e-05 0.000815364744400048 1.17353858337871 0.50561797752809 1.1 1 1 alopecia 2.43224303303184e-05 0.000519612497298561 1.17271504753072 0.505263157894737 1.1 1 1 abnormal dendritic cell physiology 8.14384942181514e-06 0.000211033948830296 1.17134505331632 0.504672897196262 1.1 1 1 abnormal embryo size 4.72060039289812e-06 0.000131201044439487 1.17076917079256 0.504424778761062 1.1 1 1 preweaning lethality, incomplete penetrance 5.88932248658198e-18 1.74849316549208e-15 1.16901148533905 0.503667481662592 1.1 1 1 abnormal blood vessel morphology 2.61261814509888e-07 9.699832292438e-06 1.16850270899792 0.503448275862069 1.1 1 1 decreased T cell number 6.18624635647638e-08 2.67622396725826e-06 1.16770733575943 0.503105590062112 1.1 1 1 decreased total body fat amount 7.5148688316696e-15 1.28918870474332e-12 1.16744836318552 0.502994011976048 1.1 1 1 decreased cell proliferation 7.16524177264219e-09 4.09736526653965e-07 1.16677223478986 0.502702702702703 1.1 1 1 decreased body weight 1.65704469441885e-51 8.2437973547338e-48 1.16612365641139 0.502423263327948 1.1 1 1 neonatal lethality, complete penetrance 1.3442461930194e-19 5.57302067522628e-17 1.16558917484607 0.50219298245614 1.1 1 1 abnormal immune system physiology 2.69719006260753e-06 8.08344612136896e-05 1.16049926578561 0.5 1.1 1 1 reduced long term potentiation 8.01728230750082e-06 0.000211033948830296 1.16049926578561 0.5 1.1 1 1 cleft secondary palate 4.14390553706539e-05 0.000808467844976483 1.16049926578561 0.5 1.1 1 1 small kidney 7.18585224021399e-05 0.00128134820412418 1.16049926578561 0.5 1.1 1 1 domed cranium 0.000379320453313113 0.00478964277977852 1.16049926578561 0.5 1.1 1 1 short stride length 0.00248915680338487 0.0218020336211967 1.16049926578561 0.5 1.1 1 1 abnormal digestive system physiology 0.00248915680338487 0.0218020336211967 1.16049926578561 0.5 1.1 1 1 decreased circulating alkaline phosphatase level 0.00248915680338487 0.0218020336211967 1.16049926578561 0.5 1.1 1 1 abnormal circulating protein level 0.00248915680338487 0.0218020336211967 1.16049926578561 0.5 1.1 1 1 curly tail 0.00301297543743459 0.0249825880020618 1.16049926578561 0.5 1.1 1 1 abnormal myelopoiesis 0.00442385832036265 0.0329471484188685 1.16049926578561 0.5 1.1 1 1 omphalocele 0.00442385832036265 0.0329471484188685 1.16049926578561 0.5 1.1 1 1 lethality, incomplete penetrance 0.00442385832036265 0.0329471484188685 1.16049926578561 0.5 1.1 1 1 disheveled coat 0.00536682912421877 0.038583778747093 1.16049926578561 0.5 1.1 1 1 myoclonus 0.0214040890432787 0.10738204572766 1.16049926578561 0.5 1.1 1 1 small superior cervical ganglion 0.0214040890432787 0.10738204572766 1.16049926578561 0.5 1.1 1 1 abnormal retinal inner nuclear layer morphology 0.0214040890432787 0.10738204572766 1.16049926578561 0.5 1.1 1 1 abnormal hormone level 0.0214040890432787 0.10738204572766 1.16049926578561 0.5 1.1 1 1 abnormal brainstem morphology 0.0214040890432787 0.10738204572766 1.16049926578561 0.5 1.1 1 1 decreased metastatic potential 0.0322410749201916 0.134225395588245 1.16049926578561 0.5 1.1 1 1 ocular hypertelorism 0.0322410749201916 0.134225395588245 1.16049926578561 0.5 1.1 1 1 increased stereotypic behavior 0.0322410749201916 0.134225395588245 1.16049926578561 0.5 1.1 1 1 abnormal startle reflex 0.0322410749201916 0.134225395588245 1.16049926578561 0.5 1.1 1 1 blindness 0.0322410749201916 0.134225395588245 1.16049926578561 0.5 1.1 1 1 abnormal sensory capabilities/reflexes/nociception 0.0322410749201916 0.134225395588245 1.16049926578561 0.5 1.1 1 1 abnormal primitive streak formation 0.0322410749201916 0.134225395588245 1.16049926578561 0.5 1.1 1 1 abnormal facial nerve morphology 0.0397142079293025 0.157936198599744 1.16049926578561 0.5 1.1 1 1 increased activated T cell number 0.0397142079293025 0.157936198599744 1.16049926578561 0.5 1.1 1 1 abnormal oogenesis 0.0397142079293025 0.157936198599744 1.16049926578561 0.5 1.1 1 1 abnormal chorion morphology 0.0397142079293025 0.157936198599744 1.16049926578561 0.5 1.1 1 1 abnormal female reproductive system physiology 0.0397142079293025 0.157936198599744 1.16049926578561 0.5 1.1 1 1 abnormal blood-brain barrier function 0.0397142079293025 0.157936198599744 1.16049926578561 0.5 1.1 1 1 decreased circulating estradiol level 0.0397142079293025 0.157936198599744 1.16049926578561 0.5 1.1 1 1 abnormal occipital bone morphology 0.0397142079293025 0.157936198599744 1.16049926578561 0.5 1.1 1 1 failure of palatal shelf elevation 0.0397142079293025 0.157936198599744 1.16049926578561 0.5 1.1 1 1 rough coat 0.0397142079293025 0.157936198599744 1.16049926578561 0.5 1.1 1 1 increased adenoma incidence 0.0397142079293025 0.157936198599744 1.16049926578561 0.5 1.1 1 1 abnormal tympanic ring morphology 0.0757594007145008 0.249667084915636 1.16049926578561 0.5 1.1 1 1 abnormal bone marrow cell number 0.0757594007145008 0.249667084915636 1.16049926578561 0.5 1.1 1 1 decreased mast cell number 0.0757594007145008 0.249667084915636 1.16049926578561 0.5 1.1 1 1 abnormal mouth morphology 0.0757594007145008 0.249667084915636 1.16049926578561 0.5 1.1 1 1 disorganized yolk sac vascular plexus 0.0757594007145008 0.249667084915636 1.16049926578561 0.5 1.1 1 1 intraventricular hemorrhage 0.0757594007145008 0.249667084915636 1.16049926578561 0.5 1.1 1 1 abnormal olfaction 0.0757594007145008 0.249667084915636 1.16049926578561 0.5 1.1 1 1 increased intestinal adenocarcinoma incidence 0.0757594007145008 0.249667084915636 1.16049926578561 0.5 1.1 1 1 abnormal pulmonary elastic fiber morphology 0.0757594007145008 0.249667084915636 1.16049926578561 0.5 1.1 1 1 abnormal epididymis epithelium morphology 0.0757594007145008 0.249667084915636 1.16049926578561 0.5 1.1 1 1 sepsis 0.0757594007145008 0.249667084915636 1.16049926578561 0.5 1.1 1 1 impaired behavioral response to addictive substance 0.0757594007145008 0.249667084915636 1.16049926578561 0.5 1.1 1 1 translucent skin 0.0948531184099409 0.265109137128908 1.16049926578561 0.5 1.1 1 1 increased aggression towards males 0.0948531184099409 0.265109137128908 1.16049926578561 0.5 1.1 1 1 abnormal adrenal gland secretion 0.0948531184099409 0.265109137128908 1.16049926578561 0.5 1.1 1 1 abnormal fluid regulation 0.0948531184099409 0.265109137128908 1.16049926578561 0.5 1.1 1 1 abnormal kidney medulla morphology 0.0948531184099409 0.265109137128908 1.16049926578561 0.5 1.1 1 1 decreased coping response 0.0948531184099409 0.265109137128908 1.16049926578561 0.5 1.1 1 1 absent olfactory bulb 0.0948531184099409 0.265109137128908 1.16049926578561 0.5 1.1 1 1 abnormal uterus development 0.0948531184099409 0.265109137128908 1.16049926578561 0.5 1.1 1 1 abnormal pancreas development 0.0948531184099409 0.265109137128908 1.16049926578561 0.5 1.1 1 1 decreased CNS synapse formation 0.0948531184099409 0.265109137128908 1.16049926578561 0.5 1.1 1 1 premature hair loss 0.0948531184099409 0.265109137128908 1.16049926578561 0.5 1.1 1 1 increased pulmonary respiratory rate 0.0948531184099409 0.265109137128908 1.16049926578561 0.5 1.1 1 1 pulmonary alveolar hemorrhage 0.0948531184099409 0.265109137128908 1.16049926578561 0.5 1.1 1 1 abnormal vitelline vein topology 0.0948531184099409 0.265109137128908 1.16049926578561 0.5 1.1 1 1 amyloidosis 0.119582961658957 0.319337216453736 1.16049926578561 0.5 1.1 1 1 abnormal enteric nervous system morphology 0.119582961658957 0.319337216453736 1.16049926578561 0.5 1.1 1 1 myocarditis 0.119582961658957 0.319337216453736 1.16049926578561 0.5 1.1 1 1 increased papilloma incidence 0.119582961658957 0.319337216453736 1.16049926578561 0.5 1.1 1 1 increased growth rate 0.119582961658957 0.319337216453736 1.16049926578561 0.5 1.1 1 1 abnormal AMPA-mediated synaptic currents 0.119582961658957 0.319337216453736 1.16049926578561 0.5 1.1 1 1 increased urine phosphate level 0.119582961658957 0.319337216453736 1.16049926578561 0.5 1.1 1 1 stria vascularis degeneration 0.119582961658957 0.319337216453736 1.16049926578561 0.5 1.1 1 1 abnormal B cell proliferation 0.119582961658957 0.319337216453736 1.16049926578561 0.5 1.1 1 1 hematuria 0.119582961658957 0.319337216453736 1.16049926578561 0.5 1.1 1 1 increased fibrosarcoma incidence 0.119582961658957 0.319337216453736 1.16049926578561 0.5 1.1 1 1 prenatal growth retardation 0.119582961658957 0.319337216453736 1.16049926578561 0.5 1.1 1 1 embryonic lethality between implantation and placentation, incomplete penetrance 0.119582961658957 0.319337216453736 1.16049926578561 0.5 1.1 1 1 ataxia 2.40667604661533e-09 1.57542280683043e-07 1.16049926578561 0.5 1.1 1 1 increased oxygen consumption 8.63652791146032e-05 0.00147298451912628 1.16049926578561 0.5 1.1 1 1 abnormal angiogenesis 0.000261594919641888 0.003635292528543 1.16049926578561 0.5 1.1 1 1 increased granulocyte number 0.000261594919641888 0.003635292528543 1.16049926578561 0.5 1.1 1 1 increased erythrocyte cell number 0.000966251291617578 0.0102278727144627 1.16049926578561 0.5 1.1 1 1 abnormal maxilla morphology 0.00170204508863352 0.0163523590701601 1.16049926578561 0.5 1.1 1 1 abnormal apoptosis 0.00170204508863352 0.0163523590701601 1.16049926578561 0.5 1.1 1 1 decreased tumor growth/size 0.00170204508863352 0.0163523590701601 1.16049926578561 0.5 1.1 1 1 decreased IgA level 0.00205770985514945 0.0188528665365903 1.16049926578561 0.5 1.1 1 1 abnormal forelimb morphology 0.00364952846862863 0.0291435058289365 1.16049926578561 0.5 1.1 1 1 abnormal allantois morphology 0.00364952846862863 0.0291435058289365 1.16049926578561 0.5 1.1 1 1 delayed wound healing 0.00364952846862863 0.0291435058289365 1.16049926578561 0.5 1.1 1 1 increased grooming behavior 0.00792032734029388 0.0522797245773669 1.16049926578561 0.5 1.1 1 1 decreased total retina thickness 0.00792032734029388 0.0522797245773669 1.16049926578561 0.5 1.1 1 1 abnormal uterus morphology 0.00963679848263036 0.0590664486148222 1.16049926578561 0.5 1.1 1 1 abnormal epidermis stratum granulosum morphology 0.00963679848263036 0.0590664486148222 1.16049926578561 0.5 1.1 1 1 abnormal retinal photoreceptor morphology 0.0117391983893464 0.065108709015606 1.16049926578561 0.5 1.1 1 1 overexpanded pulmonary alveoli 0.0117391983893464 0.065108709015606 1.16049926578561 0.5 1.1 1 1 increased metastatic potential 0.0174921851388692 0.0909337733185727 1.16049926578561 0.5 1.1 1 1 abnormal response to new environment 0.0174921851388692 0.0909337733185727 1.16049926578561 0.5 1.1 1 1 enhanced paired-pulse facilitation 0.0174921851388692 0.0909337733185727 1.16049926578561 0.5 1.1 1 1 abnormal leukocyte cell number 0.0262408277931396 0.122797653292683 1.16049926578561 0.5 1.1 1 1 abnormal Schwann cell morphology 0.0262408277931396 0.122797653292683 1.16049926578561 0.5 1.1 1 1 small seminal vesicle 0.0262408277931396 0.122797653292683 1.16049926578561 0.5 1.1 1 1 increased leukemia incidence 0.0262408277931396 0.122797653292683 1.16049926578561 0.5 1.1 1 1 increased thymocyte apoptosis 0.0262408277931396 0.122797653292683 1.16049926578561 0.5 1.1 1 1 abnormal vascular regression 0.0490660314650774 0.185207516342003 1.16049926578561 0.5 1.1 1 1 small gonad 0.0490660314650774 0.185207516342003 1.16049926578561 0.5 1.1 1 1 increased mammary adenocarcinoma incidence 0.0490660314650774 0.185207516342003 1.16049926578561 0.5 1.1 1 1 abnormal hearing physiology 0.0490660314650774 0.185207516342003 1.16049926578561 0.5 1.1 1 1 abnormal fibula morphology 0.0490660314650774 0.185207516342003 1.16049926578561 0.5 1.1 1 1 decreased paired-pulse facilitation 0.0490660314650774 0.185207516342003 1.16049926578561 0.5 1.1 1 1 decreased skin tensile strength 0.0490660314650774 0.185207516342003 1.16049926578561 0.5 1.1 1 1 abnormal thymocyte activation 0.0490660314650774 0.185207516342003 1.16049926578561 0.5 1.1 1 1 abnormal postnatal subventricular zone morphology 0.0490660314650774 0.185207516342003 1.16049926578561 0.5 1.1 1 1 abnormal incus morphology 0.0490660314650774 0.185207516342003 1.16049926578561 0.5 1.1 1 1 abnormal response to tactile stimuli 0.0490660314650774 0.185207516342003 1.16049926578561 0.5 1.1 1 1 lowered ear position 0.0608367825787413 0.215986447912804 1.16049926578561 0.5 1.1 1 1 underdeveloped hair follicles 0.0608367825787413 0.215986447912804 1.16049926578561 0.5 1.1 1 1 abnormal retinal rod cell morphology 0.0608367825787413 0.215986447912804 1.16049926578561 0.5 1.1 1 1 abnormal white adipose tissue morphology 0.0608367825787413 0.215986447912804 1.16049926578561 0.5 1.1 1 1 decreased cellular sensitivity to gamma-irradiation 0.0608367825787413 0.215986447912804 1.16049926578561 0.5 1.1 1 1 abnormal body wall morphology 0.0608367825787413 0.215986447912804 1.16049926578561 0.5 1.1 1 1 decreased activity of thyroid 0.0608367825787413 0.215986447912804 1.16049926578561 0.5 1.1 1 1 abnormal neutrophil morphology 0.0608367825787413 0.215986447912804 1.16049926578561 0.5 1.1 1 1 abnormal anterior eye segment morphology 0.0608367825787413 0.215986447912804 1.16049926578561 0.5 1.1 1 1 abnormal pregnancy 0.0608367825787413 0.215986447912804 1.16049926578561 0.5 1.1 1 1 abnormal macrophage chemotaxis 0.0608367825787413 0.215986447912804 1.16049926578561 0.5 1.1 1 1 impaired leukocyte tethering or rolling 0.0608367825787413 0.215986447912804 1.16049926578561 0.5 1.1 1 1 increased adipocyte glucose uptake 0.0608367825787413 0.215986447912804 1.16049926578561 0.5 1.1 1 1 abnormal lateral semicircular canal morphology 0.15215338187304 0.380957762867829 1.16049926578561 0.5 1.1 1 1 abnormal auchene hair morphology 0.15215338187304 0.380957762867829 1.16049926578561 0.5 1.1 1 1 kidney hemorrhage 0.15215338187304 0.380957762867829 1.16049926578561 0.5 1.1 1 1 jaundice 0.15215338187304 0.380957762867829 1.16049926578561 0.5 1.1 1 1 abnormal respiratory mechanics 0.15215338187304 0.380957762867829 1.16049926578561 0.5 1.1 1 1 decreased circulating parathyroid hormone level 0.15215338187304 0.380957762867829 1.16049926578561 0.5 1.1 1 1 abnormal primordial germ cell migration 0.15215338187304 0.380957762867829 1.16049926578561 0.5 1.1 1 1 primary sex reversal 0.15215338187304 0.380957762867829 1.16049926578561 0.5 1.1 1 1 abnormal hypaxial muscle morphology 0.15215338187304 0.380957762867829 1.16049926578561 0.5 1.1 1 1 lymphedema 0.15215338187304 0.380957762867829 1.16049926578561 0.5 1.1 1 1 abnormal hindlimb zeugopod morphology 0.15215338187304 0.380957762867829 1.16049926578561 0.5 1.1 1 1 absent pharyngeal arches 0.15215338187304 0.380957762867829 1.16049926578561 0.5 1.1 1 1 abnormal plasma membrane morphology 0.15215338187304 0.380957762867829 1.16049926578561 0.5 1.1 1 1 abnormal placental transport 0.15215338187304 0.380957762867829 1.16049926578561 0.5 1.1 1 1 abnormal cochlear inner hair cell physiology 0.15215338187304 0.380957762867829 1.16049926578561 0.5 1.1 1 1 abnormal gonadal fat pad morphology 0.15215338187304 0.380957762867829 1.16049926578561 0.5 1.1 1 1 decreased thyroxine level 0.15215338187304 0.380957762867829 1.16049926578561 0.5 1.1 1 1 abnormal developmental vascular remodeling 0.15215338187304 0.380957762867829 1.16049926578561 0.5 1.1 1 1 crystalluria 0.15215338187304 0.380957762867829 1.16049926578561 0.5 1.1 1 1 ventricular premature beat 0.15215338187304 0.380957762867829 1.16049926578561 0.5 1.1 1 1 abnormal hippocampus neuron morphology 0.15215338187304 0.380957762867829 1.16049926578561 0.5 1.1 1 1 aorta stenosis 0.15215338187304 0.380957762867829 1.16049926578561 0.5 1.1 1 1 abnormal inferior vena cava valve morphology 0.15215338187304 0.380957762867829 1.16049926578561 0.5 1.1 1 1 sinus bradycardia 0.15215338187304 0.380957762867829 1.16049926578561 0.5 1.1 1 1 fusion of atlas and odontoid process 0.15215338187304 0.380957762867829 1.16049926578561 0.5 1.1 1 1 abnormal pulmonary interalveolar septum morphology 0.15215338187304 0.380957762867829 1.16049926578561 0.5 1.1 1 1 increased compact bone area 0.15215338187304 0.380957762867829 1.16049926578561 0.5 1.1 1 1 lethality during fetal growth through weaning, complete penetrance 0.15215338187304 0.380957762867829 1.16049926578561 0.5 1.1 1 1 reduced male fertility 3.93402812361245e-10 3.10663331983681e-08 1.15538693421827 0.497797356828194 1.1 1 1 abnormal spatial learning 1.22566651474083e-07 5.0394139758972e-06 1.15337963838815 0.496932515337423 1.1 1 1 increased heart weight 1.06668132405325e-06 3.56157019272813e-05 1.15215035020442 0.496402877697842 1.1 1 1 hyperactivity 2.33905058254873e-15 4.84865693674163e-13 1.15111517468761 0.495956873315364 1.1 1 1 preweaning lethality, complete penetrance 2.99406939035719e-29 2.48258253617117e-26 1.15108981227924 0.495945945945946 1.1 1 1 cataract 5.44184608141459e-06 0.000147136870951291 1.15090836276259 0.495867768595041 1.1 1 1 increased bone mineral density 1.1256127697286e-05 0.000275850611476772 1.15022936077866 0.495575221238938 1.1 1 1 limb grasping 3.39227673663837e-08 1.60729302521675e-06 1.14774652660115 0.494505494505495 1.1 1 1 small spleen 8.39946930754296e-05 0.00146109649667924 1.14774652660115 0.494505494505495 1.1 1 1 hypoactivity 3.1641933784726e-15 6.29674482316048e-13 1.14510802883885 0.493368700265252 1.1 1 1 male infertility 9.1013098792968e-20 4.11627424086378e-17 1.14434917659973 0.493041749502982 1.1 1 1 abnormal embryo development 2.1339899319932e-06 6.55345673559641e-05 1.14343310011229 0.492647058823529 1.1 1 1 decreased monocyte cell number 0.000933369351921057 0.00998604844259626 1.14264543092737 0.492307692307692 1.1 1 1 embryonic lethality, complete penetrance 5.64419502346155e-13 7.79996395603367e-11 1.14230962212126 0.492163009404389 1.1 1 1 increased osteoclast cell number 0.0013584928142407 0.0136260115944505 1.14147468765798 0.491803278688525 1.1 1 1 increased double-negative T cell number 0.0013584928142407 0.0136260115944505 1.14147468765798 0.491803278688525 1.1 1 1 decreased body size 4.42698772407672e-30 4.40485278545634e-27 1.14013962954376 0.491228070175439 1.1 1 1 abnormal embryo turning 0.00239361384240944 0.0215338677504285 1.13939927913496 0.490909090909091 1.1 1 1 abnormal axon morphology 2.70522595959492e-05 0.000565483157520367 1.13900853864143 0.490740740740741 1.1 1 1 enlarged kidney 0.00289406433838897 0.0243314826709083 1.13860305322362 0.490566037735849 1.1 1 1 abnormal thrombosis 0.00350121210947078 0.0281853240204161 1.13774437822119 0.490196078431373 1.1 1 1 improved glucose tolerance 2.21965921143496e-08 1.10428045768889e-06 1.13681560730019 0.489795918367347 1.1 1 1 increased fluid intake 0.0042384285086095 0.0321926440157745 1.13681560730019 0.489795918367347 1.1 1 1 increased susceptibility to pharmacologically induced seizures 8.09262989493368e-05 0.00141763499039771 1.13632219774841 0.489583333333333 1.1 1 1 hepatic necrosis 0.00513440279463064 0.0372256012947029 1.13580779204549 0.48936170212766 1.1 1 1 increased cellular sensitivity to gamma-irradiation 0.00513440279463064 0.0372256012947029 1.13580779204549 0.48936170212766 1.1 1 1 neuron degeneration 0.00513440279463064 0.0372256012947029 1.13580779204549 0.48936170212766 1.1 1 1 small testis 3.95891283730064e-11 3.93911827311414e-09 1.13527102087723 0.489130434782609 1.1 1 1 abnormal ovarian follicle morphology 0.00622441945944309 0.0432003932122688 1.1347103932126 0.488888888888889 1.1 1 1 decreased osteoclast cell number 0.00622441945944309 0.0432003932122688 1.1347103932126 0.488888888888889 1.1 1 1 abnormal metabolism 0.00622441945944309 0.0432003932122688 1.1347103932126 0.488888888888889 1.1 1 1 cardiomyopathy 0.00622441945944309 0.0432003932122688 1.1347103932126 0.488888888888889 1.1 1 1 hyperglycemia 0.000168580932158455 0.00259656389315268 1.1341242824723 0.488636363636364 1.1 1 1 abnormal axon guidance 0.00755196679329915 0.0503633174218007 1.13351091076734 0.488372093023256 1.1 1 1 abnormal double-strand DNA break repair 0.00755196679329915 0.0503633174218007 1.13351091076734 0.488372093023256 1.1 1 1 Leydig cell hyperplasia 0.0091707721380285 0.0570307392333647 1.1321944056445 0.48780487804878 1.1 1 1 increased rib number 0.000423913454261098 0.00522022137363604 1.13074287435521 0.487179487179487 1.1 1 1 increased urine protein level 0.000423913454261098 0.00522022137363604 1.13074287435521 0.487179487179487 1.1 1 1 abnormal iris morphology 0.0111473908177767 0.0635260816935156 1.13074287435521 0.487179487179487 1.1 1 1 abnormal bone structure 4.36781583516484e-08 1.99681550186783e-06 1.13043451796733 0.487046632124352 1.1 1 1 increased trabecular bone volume 0.0135645195432629 0.0731132012218126 1.12913442076438 0.486486486486487 1.1 1 1 abnormal neuromuscular synapse morphology 0.000739444336970166 0.00815684163287489 1.12826317506934 0.486111111111111 1.1 1 1 abnormal inflammatory response 0.000739444336970166 0.00815684163287489 1.12826317506934 0.486111111111111 1.1 1 1 increased T cell proliferation 4.47723817321024e-05 0.000851288604424587 1.12796190319349 0.485981308411215 1.1 1 1 abnormal retina morphology 1.43149256212343e-08 7.65771558770329e-07 1.12734214390602 0.485714285714286 1.1 1 1 decreased bone mineralization 0.0165252668499343 0.0862677886447254 1.12734214390602 0.485714285714286 1.1 1 1 abnormal epidermis stratum basale morphology 0.0201587016922304 0.102336266243721 1.12533262136786 0.484848484848485 1.1 1 1 abnormal QRS complex 0.0201587016922304 0.102336266243721 1.12533262136786 0.484848484848485 1.1 1 1 head tossing 0.0201587016922304 0.102336266243721 1.12533262136786 0.484848484848485 1.1 1 1 increased or absent threshold for auditory brainstem response 4.17442114125406e-11 4.07210689759587e-09 1.12435915024211 0.484429065743945 1.1 1 1 increased inflammatory response 0.000133805235361647 0.00212000333096877 1.12385192055027 0.484210526315789 1.1 1 1 decreased litter size 8.50618949588491e-11 7.83672087815323e-09 1.12333025015547 0.483985765124555 1.1 1 1 prenatal lethality 0.00188131379615023 0.0173646310498097 1.12306380559898 0.483870967741935 1.1 1 1 abnormal postnatal growth/weight/body size 0.0246271307250323 0.119648413434605 1.12306380559898 0.483870967741935 1.1 1 1 abnormal CD8-positive, alpha beta T cell morphology 0.0246271307250323 0.119648413434605 1.12306380559898 0.483870967741935 1.1 1 1 abnormal podocyte morphology 0.0246271307250323 0.119648413434605 1.12306380559898 0.483870967741935 1.1 1 1 increased sensitivity to induced morbidity/mortality 1.46129390811123e-07 5.86285257488175e-06 1.12265689842304 0.483695652173913 1.1 1 1 microphthalmia 1.5747433504937e-06 5.02201805686292e-05 1.12257445317824 0.483660130718954 1.1 1 1 abnormal glucose homeostasis 1.74744265749332e-07 6.84529702443251e-06 1.12224104823224 0.483516483516484 1.1 1 1 abnormal eating behavior 0.00227028299416121 0.0204984716804937 1.12181595692609 0.483333333333333 1.1 1 1 abnormal spleen morphology 3.57405203143497e-07 1.30741976885213e-05 1.12048204972404 0.482758620689655 1.1 1 1 abnormal spermiogenesis 0.00274090476008746 0.0232696265894797 1.12048204972404 0.482758620689655 1.1 1 1 cochlear ganglion degeneration 0.00274090476008746 0.0232696265894797 1.12048204972404 0.482758620689655 1.1 1 1 abnormal embryonic neuroepithelium morphology 0.00274090476008746 0.0232696265894797 1.12048204972404 0.482758620689655 1.1 1 1 abnormal enzyme/coenzyme level 0.00274090476008746 0.0232696265894797 1.12048204972404 0.482758620689655 1.1 1 1 blood in lymph vessels 0.0301357479632936 0.131976537075164 1.12048204972404 0.482758620689655 1.1 1 1 short tail 0.000402301706526046 0.00503468694325344 1.11855350919095 0.481927710843373 1.1 1 1 postnatal lethality, complete penetrance 5.44653785262389e-14 8.74081477961414e-12 1.11840861884002 0.481865284974093 1.1 1 1 increased circulating alkaline phosphatase level 1.04623402339601e-06 3.51690153134807e-05 1.11751781149725 0.481481481481481 1.1 1 1 decreased heart weight 0.000483659809950477 0.00572906560596101 1.11751781149725 0.481481481481481 1.1 1 1 abnormal small intestine morphology 0.004000939356019 0.0306225743018377 1.11751781149725 0.481481481481481 1.1 1 1 impaired limb coordination 0.004000939356019 0.0306225743018377 1.11751781149725 0.481481481481481 1.1 1 1 neurodegeneration 0.004000939356019 0.0306225743018377 1.11751781149725 0.481481481481481 1.1 1 1 abnormal long bone epiphyseal plate proliferative zone 0.004000939356019 0.0306225743018377 1.11751781149725 0.481481481481481 1.1 1 1 decreased platelet aggregation 0.004000939356019 0.0306225743018377 1.11751781149725 0.481481481481481 1.1 1 1 rectal prolapse 0.0369455958251854 0.150659294451063 1.11751781149725 0.481481481481481 1.1 1 1 wrinkled skin 0.0369455958251854 0.150659294451063 1.11751781149725 0.481481481481481 1.1 1 1 abnormal eye muscle morphology 0.0369455958251854 0.150659294451063 1.11751781149725 0.481481481481481 1.1 1 1 abnormal myocardium layer morphology 0.000581604736091698 0.00676047561228084 1.116429673414 0.481012658227848 1.1 1 1 abnormal snout morphology 0.00483778827087941 0.0353421389832967 1.11586467864001 0.480769230769231 1.1 1 1 abnormal female meiosis 0.00483778827087941 0.0353421389832967 1.11586467864001 0.480769230769231 1.1 1 1 abnormal heart morphology 7.25655046932317e-09 4.10242483919122e-07 1.11528500867708 0.480519480519481 1.1 1 1 postnatal growth retardation 4.98698198388804e-21 2.75669281887144e-18 1.11498949065676 0.480392156862745 1.1 1 1 increased circulating chloride level 0.00585314085189372 0.0415991081973875 1.11407929515419 0.48 1.1 1 1 decreased respiratory quotient 0.00585314085189372 0.0415991081973875 1.11407929515419 0.48 1.1 1 1 decreased placenta weight 0.0453912404715525 0.177393103963844 1.11407929515419 0.48 1.1 1 1 decreased acute inflammation 0.0453912404715525 0.177393103963844 1.11407929515419 0.48 1.1 1 1 abnormal energy expenditure 0.0453912404715525 0.177393103963844 1.11407929515419 0.48 1.1 1 1 abnormal preimplantation embryo development 0.0453912404715525 0.177393103963844 1.11407929515419 0.48 1.1 1 1 abnormal kidney physiology 0.00708611596325099 0.0480947161216558 1.11214512971121 0.479166666666667 1.1 1 1 increased B cell number 4.02767761195249e-05 0.000792003799188287 1.11090528006828 0.478632478632479 1.1 1 1 abnormal carpal bone morphology 0.0559053158979323 0.206021441920158 1.11004277596884 0.478260869565217 1.1 1 1 bidirectional circling 0.0559053158979323 0.206021441920158 1.11004277596884 0.478260869565217 1.1 1 1 abnormal circulating insulin level 0.0559053158979323 0.206021441920158 1.11004277596884 0.478260869565217 1.1 1 1 abnormal postnatal growth 0.0559053158979323 0.206021441920158 1.11004277596884 0.478260869565217 1.1 1 1 increased susceptibility to age related obesity 0.0559053158979323 0.206021441920158 1.11004277596884 0.478260869565217 1.1 1 1 abnormal B cell morphology 0.0559053158979323 0.206021441920158 1.11004277596884 0.478260869565217 1.1 1 1 increased susceptibility to fungal infection 0.0559053158979323 0.206021441920158 1.11004277596884 0.478260869565217 1.1 1 1 abnormal lens development 0.0559053158979323 0.206021441920158 1.11004277596884 0.478260869565217 1.1 1 1 abnormal chondrocyte physiology 0.0559053158979323 0.206021441920158 1.11004277596884 0.478260869565217 1.1 1 1 azoospermia 2.0262861137754e-06 6.2712077978738e-05 1.10940810314096 0.477987421383648 1.1 1 1 increased total body fat amount 1.28855496401354e-05 0.00030381805431125 1.10853661209372 0.477611940298507 1.1 1 1 teratozoospermia 0.0003788991262963 0.00478964277977852 1.10774929915899 0.477272727272727 1.1 1 1 osteoporosis 0.0104080658338064 0.0626120042602017 1.10774929915899 0.477272727272727 1.1 1 1 abnormal astrocyte morphology 0.0104080658338064 0.0626120042602017 1.10774929915899 0.477272727272727 1.1 1 1 embryonic lethality, incomplete penetrance 0.0104080658338064 0.0626120042602017 1.10774929915899 0.477272727272727 1.1 1 1 abnormal nervous system electrophysiology 0.000546568153434422 0.00639806250196764 1.10523739598629 0.476190476190476 1.1 1 1 abnormal hair follicle morphology 0.00256813679081634 0.0221429471998463 1.10523739598629 0.476190476190476 1.1 1 1 skin lesions 0.00256813679081634 0.0221429471998463 1.10523739598629 0.476190476190476 1.1 1 1 abnormal cartilage morphology 0.0126289021505827 0.0688157592542706 1.10523739598629 0.476190476190476 1.1 1 1 abnormal optic nerve morphology 0.0126289021505827 0.0688157592542706 1.10523739598629 0.476190476190476 1.1 1 1 abnormal muscle morphology 0.0126289021505827 0.0688157592542706 1.10523739598629 0.476190476190476 1.1 1 1 small ears 0.0690533523247853 0.238841492273665 1.10523739598629 0.476190476190476 1.1 1 1 abnormal scapula morphology 0.0690533523247853 0.238841492273665 1.10523739598629 0.476190476190476 1.1 1 1 abnormal salivary gland morphology 0.0690533523247853 0.238841492273665 1.10523739598629 0.476190476190476 1.1 1 1 abnormal anxiety-related response 0.0690533523247853 0.238841492273665 1.10523739598629 0.476190476190476 1.1 1 1 abnormal associative learning 0.0690533523247853 0.238841492273665 1.10523739598629 0.476190476190476 1.1 1 1 dry skin 0.0690533523247853 0.238841492273665 1.10523739598629 0.476190476190476 1.1 1 1 abnormal bile salt homeostasis 0.0690533523247853 0.238841492273665 1.10523739598629 0.476190476190476 1.1 1 1 decreased vocalization 0.0690533523247853 0.238841492273665 1.10523739598629 0.476190476190476 1.1 1 1 abnormal female reproductive system morphology 0.0153371789133739 0.0816069145390751 1.10247430249633 0.475 1.1 1 1 reduced fertility 1.21204674723131e-05 0.000288147373306589 1.10205685671727 0.474820143884892 1.1 1 1 abnormal motor coordination/ balance 0.000205560231894386 0.00302364119076757 1.10188819175603 0.474747474747475 1.1 1 1 deafness 0.000205560231894386 0.00302364119076757 1.10188819175603 0.474747474747475 1.1 1 1 abnormal CNS synaptic transmission 0.000205560231894386 0.00302364119076757 1.10188819175603 0.474747474747475 1.1 1 1 impaired coordination 8.8161787070881e-12 1.02001137366891e-09 1.10012647161179 0.473988439306358 1.1 1 1 abnormal facial morphology 0.00450757038485039 0.0330754611572724 1.09942035706005 0.473684210526316 1.1 1 1 incomplete somite formation 0.0186442925259351 0.0950362247095564 1.09942035706005 0.473684210526316 1.1 1 1 abnormal retinal outer nuclear layer morphology 0.0186442925259351 0.0950362247095564 1.09942035706005 0.473684210526316 1.1 1 1 abnormal compact bone morphology 0.0186442925259351 0.0950362247095564 1.09942035706005 0.473684210526316 1.1 1 1 abnormal nail morphology 0.0855845078059697 0.256862964844569 1.09942035706005 0.473684210526316 1.1 1 1 short vibrissae 0.0855845078059697 0.256862964844569 1.09942035706005 0.473684210526316 1.1 1 1 decreased grooming behavior 0.0855845078059697 0.256862964844569 1.09942035706005 0.473684210526316 1.1 1 1 decreased chemically-elicited antinociception 0.0855845078059697 0.256862964844569 1.09942035706005 0.473684210526316 1.1 1 1 increased malignant tumor incidence 0.0855845078059697 0.256862964844569 1.09942035706005 0.473684210526316 1.1 1 1 abnormal metatarsal bone morphology 0.0855845078059697 0.256862964844569 1.09942035706005 0.473684210526316 1.1 1 1 abnormal optic vesicle formation 0.0855845078059697 0.256862964844569 1.09942035706005 0.473684210526316 1.1 1 1 absent amnion 0.0855845078059697 0.256862964844569 1.09942035706005 0.473684210526316 1.1 1 1 increased circulating VLDL cholesterol level 0.0855845078059697 0.256862964844569 1.09942035706005 0.473684210526316 1.1 1 1 Leydig cell hypoplasia 0.0855845078059697 0.256862964844569 1.09942035706005 0.473684210526316 1.1 1 1 shortened RR interval 0.0855845078059697 0.256862964844569 1.09942035706005 0.473684210526316 1.1 1 1 lethargy 0.000354590071933837 0.00454661239141969 1.09810683214122 0.473118279569892 1.1 1 1 abnormal platelet physiology 0.00544198981649656 0.0389692448794087 1.09719930583367 0.472727272727273 1.1 1 1 abnormal limb bone morphology 0.022688633283838 0.110989135287211 1.09602708435308 0.472222222222222 1.1 1 1 dehydration 0.00198311566432172 0.0182703711666677 1.09418502202643 0.471428571428571 1.1 1 1 abnormal retinal pigmentation 0.000612363992143202 0.00706847067497083 1.09380390568299 0.471264367816092 1.1 1 1 kinked tail 0.000229934780006586 0.0033157261754573 1.09223460309234 0.470588235294118 1.1 1 1 impaired balance 0.000229934780006586 0.0033157261754573 1.09223460309234 0.470588235294118 1.1 1 1 distended abdomen 0.00794374417849193 0.0522797245773669 1.09223460309234 0.470588235294118 1.1 1 1 abnormal gastrulation 0.00794374417849193 0.0522797245773669 1.09223460309234 0.470588235294118 1.1 1 1 abnormal cervical vertebrae morphology 0.00794374417849193 0.0522797245773669 1.09223460309234 0.470588235294118 1.1 1 1 abnormal gluconeogenesis 0.00794374417849193 0.0522797245773669 1.09223460309234 0.470588235294118 1.1 1 1 decreased susceptibility to injury 0.00238626396752802 0.0215066363015433 1.09223460309234 0.470588235294118 1.1 1 1 abnormal endoderm development 0.0276427046281272 0.124117739643441 1.09223460309234 0.470588235294118 1.1 1 1 abnormal spleen red pulp morphology 0.0276427046281272 0.124117739643441 1.09223460309234 0.470588235294118 1.1 1 1 increased aggression towards mice 0.106507856436247 0.288918530954377 1.09223460309234 0.470588235294118 1.1 1 1 hyperlipidemia 0.106507856436247 0.288918530954377 1.09223460309234 0.470588235294118 1.1 1 1 nephrocalcinosis 0.106507856436247 0.288918530954377 1.09223460309234 0.470588235294118 1.1 1 1 abnormal duodenum morphology 0.106507856436247 0.288918530954377 1.09223460309234 0.470588235294118 1.1 1 1 decreased growth hormone level 0.106507856436247 0.288918530954377 1.09223460309234 0.470588235294118 1.1 1 1 increased circulating magnesium level 0.106507856436247 0.288918530954377 1.09223460309234 0.470588235294118 1.1 1 1 delayed heart development 0.106507856436247 0.288918530954377 1.09223460309234 0.470588235294118 1.1 1 1 abnormal ductus venosus valve morphology 0.106507856436247 0.288918530954377 1.09223460309234 0.470588235294118 1.1 1 1 abnormal cell cytoskeleton morphology 0.106507856436247 0.288918530954377 1.09223460309234 0.470588235294118 1.1 1 1 decreased startle reflex 8.70147030094194e-05 0.00147298451912628 1.09106768578134 0.47008547008547 1.1 1 1 decreased double-positive T cell number 0.000275472216231724 0.00368608986724681 1.09086930983847 0.47 1.1 1 1 postnatal lethality 3.41033165036486e-06 9.9802352709207e-05 1.09058967146117 0.469879518072289 1.1 1 1 absent kidney 0.00960522409620308 0.0590664486148222 1.08944829032935 0.469387755102041 1.1 1 1 abnormal epidermis stratum corneum morphology 0.00960522409620308 0.0590664486148222 1.08944829032935 0.469387755102041 1.1 1 1 increased T cell derived lymphoma incidence 0.00960522409620308 0.0590664486148222 1.08944829032935 0.469387755102041 1.1 1 1 abnormal lens morphology 4.7330502677869e-05 0.000881907306450931 1.08796806167401 0.46875 1.1 1 1 abnormal urine homeostasis 0.00039548692733168 0.00497079883754171 1.08796806167401 0.46875 1.1 1 1 abnormal vertebral body morphology 0.0337223564248763 0.138081253673876 1.08796806167401 0.46875 1.1 1 1 abnormal crypts of Lieberkuhn morphology 0.0337223564248763 0.138081253673876 1.08796806167401 0.46875 1.1 1 1 abnormal lymphatic vessel morphology 0.0337223564248763 0.138081253673876 1.08796806167401 0.46875 1.1 1 1 abnormal lumbar vertebrae morphology 0.0337223564248763 0.138081253673876 1.08796806167401 0.46875 1.1 1 1 decreased susceptibility to parasitic infection 0.0337223564248763 0.138081253673876 1.08796806167401 0.46875 1.1 1 1 bradykinesia 0.0337223564248763 0.138081253673876 1.08796806167401 0.46875 1.1 1 1 altered response to myocardial infarction 0.0140687564113742 0.0756670952936074 1.08313264806657 0.466666666666667 1.1 1 1 abnormal autopod morphology 0.0140687564113742 0.0756670952936074 1.08313264806657 0.466666666666667 1.1 1 1 abnormal microglial cell physiology 0.041198865434665 0.162541122551513 1.08313264806657 0.466666666666667 1.1 1 1 liver hemorrhage 0.041198865434665 0.162541122551513 1.08313264806657 0.466666666666667 1.1 1 1 abnormal fontanelle morphology 0.133211691378176 0.342849541958833 1.08313264806657 0.466666666666667 1.1 1 1 abnormal prostate gland morphology 0.133211691378176 0.342849541958833 1.08313264806657 0.466666666666667 1.1 1 1 audiogenic seizures 0.133211691378176 0.342849541958833 1.08313264806657 0.466666666666667 1.1 1 1 absent egg cylinders 0.133211691378176 0.342849541958833 1.08313264806657 0.466666666666667 1.1 1 1 abnormal cricoid cartilage morphology 0.133211691378176 0.342849541958833 1.08313264806657 0.466666666666667 1.1 1 1 abnormal bronchus morphology 0.133211691378176 0.342849541958833 1.08313264806657 0.466666666666667 1.1 1 1 increased alcohol consumption 0.133211691378176 0.342849541958833 1.08313264806657 0.466666666666667 1.1 1 1 abnormal energy homeostasis 0.133211691378176 0.342849541958833 1.08313264806657 0.466666666666667 1.1 1 1 absent chorion 0.133211691378176 0.342849541958833 1.08313264806657 0.466666666666667 1.1 1 1 abnormal secondary palate development 0.133211691378176 0.342849541958833 1.08313264806657 0.466666666666667 1.1 1 1 bicuspid aortic valve 0.133211691378176 0.342849541958833 1.08313264806657 0.466666666666667 1.1 1 1 herniated liver 0.133211691378176 0.342849541958833 1.08313264806657 0.466666666666667 1.1 1 1 abnormal suckling behavior 0.000816024832562832 0.00882548596086975 1.08137431584568 0.465909090909091 1.1 1 1 increased liver weight 0.000816024832562832 0.00882548596086975 1.08137431584568 0.465909090909091 1.1 1 1 decreased percent body fat/body weight 0.00220267424176837 0.0199604815169356 1.0810130147044 0.465753424657534 1.1 1 1 thrombocytosis 0.00604627915480525 0.0428493430130429 1.08046483366246 0.46551724137931 1.1 1 1 abnormal T cell differentiation 0.000366019247349456 0.00464526978460088 1.08006862360245 0.465346534653465 1.1 1 1 no abnormal phenotype detected 2.31460217048411e-49 5.75757289907923e-46 1.0795653112265 0.465129682997118 1.1 1 1 abnormal homeostasis 0.0170436285482207 0.0888805576807106 1.0795342007308 0.465116279069767 1.1 1 1 abnormal skeletal muscle fiber morphology 0.00264649214497638 0.0226614430658477 1.07877396537817 0.464788732394366 1.1 1 1 rib bifurcation 0.0504149017028378 0.189436658588835 1.07760646108664 0.464285714285714 1.1 1 1 absent corpus callosum 0.0504149017028378 0.189436658588835 1.07760646108664 0.464285714285714 1.1 1 1 enhanced coordination 0.0504149017028378 0.189436658588835 1.07760646108664 0.464285714285714 1.1 1 1 corneal vascularization 0.0504149017028378 0.189436658588835 1.07760646108664 0.464285714285714 1.1 1 1 abnormal renal tubule epithelium morphology 0.0504149017028378 0.189436658588835 1.07760646108664 0.464285714285714 1.1 1 1 abnormal behavior 7.14618322294479e-09 4.09736526653965e-07 1.0770101099737 0.464028776978417 1.1 1 1 embryonic lethality before implantation, complete penetrance 8.94232218943665e-05 0.00150478353772547 1.07694331864905 0.464 1.1 1 1 abnormal food intake 0.00318035195490565 0.0260642216857022 1.076405116091 0.463768115942029 1.1 1 1 decreased body length 1.01207010072202e-08 5.59449861232451e-07 1.07579129018082 0.463503649635036 1.1 1 1 abnormal excitatory postsynaptic potential 0.00140627911298146 0.0140769388070076 1.07558468536227 0.463414634146341 1.1 1 1 arrested B cell differentiation 0.0206627120375359 0.104468488197908 1.07558468536227 0.463414634146341 1.1 1 1 abnormal cholesterol homeostasis 0.0206627120375359 0.104468488197908 1.07558468536227 0.463414634146341 1.1 1 1 decreased birth weight 0.000627762040760611 0.00721273938287308 1.07498879356983 0.463157894736842 1.1 1 1 abnormal mandible morphology 0.00879077047440703 0.0549423154650439 1.0745363572089 0.462962962962963 1.1 1 1 decreased compact bone thickness 0.00382267487062324 0.02983198232415 1.07389484296579 0.462686567164179 1.1 1 1 insulin resistance 6.91082908989934e-05 0.00123674009792263 1.07258265474124 0.462121212121212 1.1 1 1 abnormal lipid homeostasis 8.24714303244024e-05 0.00143963286268036 1.07123009149441 0.461538461538462 1.1 1 1 absent corpus luteum 0.0106059920993027 0.0633016694180401 1.07123009149441 0.461538461538462 1.1 1 1 abnormal skin condition 0.0106059920993027 0.0633016694180401 1.07123009149441 0.461538461538462 1.1 1 1 abnormal leukocyte adhesion 0.025070208275785 0.121445264042873 1.07123009149441 0.461538461538462 1.1 1 1 failure of heart looping 0.025070208275785 0.121445264042873 1.07123009149441 0.461538461538462 1.1 1 1 abnormal circulating hormone level 0.025070208275785 0.121445264042873 1.07123009149441 0.461538461538462 1.1 1 1 increased susceptibility to otitis media 0.0618058799101924 0.2190058778869 1.07123009149441 0.461538461538462 1.1 1 1 decreased circulating glycerol level 0.0618058799101924 0.2190058778869 1.07123009149441 0.461538461538462 1.1 1 1 short hair 0.167659421495612 0.398521558500081 1.07123009149441 0.461538461538462 1.1 1 1 abnormal sympathetic ganglion morphology 0.167659421495612 0.398521558500081 1.07123009149441 0.461538461538462 1.1 1 1 pup cannibalization 0.167659421495612 0.398521558500081 1.07123009149441 0.461538461538462 1.1 1 1 abnormal otolith morphology 0.167659421495612 0.398521558500081 1.07123009149441 0.461538461538462 1.1 1 1 anal atresia 0.167659421495612 0.398521558500081 1.07123009149441 0.461538461538462 1.1 1 1 abnormal insulin secretion 0.167659421495612 0.398521558500081 1.07123009149441 0.461538461538462 1.1 1 1 increased circulating ammonia level 0.167659421495612 0.398521558500081 1.07123009149441 0.461538461538462 1.1 1 1 orthokeratosis 0.167659421495612 0.398521558500081 1.07123009149441 0.461538461538462 1.1 1 1 abnormal aorta tunica media morphology 0.167659421495612 0.398521558500081 1.07123009149441 0.461538461538462 1.1 1 1 decreased cardiac stroke volume 0.167659421495612 0.398521558500081 1.07123009149441 0.461538461538462 1.1 1 1 abnormal cytokine secretion 2.0401669119356e-05 0.000445167999424544 1.07007075156855 0.461038961038961 1.1 1 1 gliosis 0.00552622498848109 0.0393882081915379 1.06839614945342 0.46031746031746 1.1 1 1 abnormal hindlimb morphology 0.0128014431561703 0.0694516681591573 1.06765932452276 0.46 1.1 1 1 increased body length 0.0128014431561703 0.0694516681591573 1.06765932452276 0.46 1.1 1 1 testicular atrophy 0.0128014431561703 0.0694516681591573 1.06765932452276 0.46 1.1 1 1 abnormal T cell activation 0.00290985461156885 0.0243314826709083 1.06640473072191 0.459459459459459 1.1 1 1 abnormal long bone metaphysis morphology 0.0304441299633269 0.132072929200835 1.06640473072191 0.459459459459459 1.1 1 1 decreased circulating chloride level 0.0304441299633269 0.132072929200835 1.06640473072191 0.459459459459459 1.1 1 1 abnormal hair follicle development 0.0304441299633269 0.132072929200835 1.06640473072191 0.459459459459459 1.1 1 1 cochlear outer hair cell degeneration 0.00349094081469535 0.0281481856614414 1.06379099363681 0.458333333333333 1.1 1 1 abnormal intestinal epithelium morphology 0.0154582642132153 0.0817267422537152 1.06379099363681 0.458333333333333 1.1 1 1 abnormal cardiovascular system morphology 0.0154582642132153 0.0817267422537152 1.06379099363681 0.458333333333333 1.1 1 1 small heart 0.0154582642132153 0.0817267422537152 1.06379099363681 0.458333333333333 1.1 1 1 abnormal lymph node morphology 0.0154582642132153 0.0817267422537152 1.06379099363681 0.458333333333333 1.1 1 1 abnormal phalanx morphology 0.0154582642132153 0.0817267422537152 1.06379099363681 0.458333333333333 1.1 1 1 abnormal malleus morphology 0.0759289044175591 0.249667084915636 1.06379099363681 0.458333333333333 1.1 1 1 abnormal foregut morphology 0.0759289044175591 0.249667084915636 1.06379099363681 0.458333333333333 1.1 1 1 abnormal body weight 0.0759289044175591 0.249667084915636 1.06379099363681 0.458333333333333 1.1 1 1 curly vibrissae 0.0759289044175591 0.249667084915636 1.06379099363681 0.458333333333333 1.1 1 1 apnea 0.0759289044175591 0.249667084915636 1.06379099363681 0.458333333333333 1.1 1 1 hypopigmentation 0.0759289044175591 0.249667084915636 1.06379099363681 0.458333333333333 1.1 1 1 increased body temperature 0.0759289044175591 0.249667084915636 1.06379099363681 0.458333333333333 1.1 1 1 abnormal truncus arteriosus septation 0.0759289044175591 0.249667084915636 1.06379099363681 0.458333333333333 1.1 1 1 abnormal colon morphology 0.00799619359959263 0.0522797245773669 1.06215187038005 0.457627118644068 1.1 1 1 abnormal humoral immune response 0.000527950281778227 0.00620934433060681 1.06102790014684 0.457142857142857 1.1 1 1 thick epidermis 0.00418855093644999 0.0319112418205799 1.06102790014684 0.457142857142857 1.1 1 1 increased carcinoma incidence 0.0370047574939738 0.150776960305094 1.06102790014684 0.457142857142857 1.1 1 1 decreased grip strength 8.35232502221785e-07 2.84608335517355e-05 1.05981668108275 0.45662100456621 1.1 1 1 seizures 0.000338743210640292 0.00436592609568771 1.05870108457635 0.456140350877193 1.1 1 1 incomplete embryo turning 0.00962205167958597 0.0590664486148222 1.05870108457635 0.456140350877193 1.1 1 1 decreased brain weight 0.00962205167958597 0.0590664486148222 1.05870108457635 0.456140350877193 1.1 1 1 abnormal circulating amino acid level 0.00962205167958597 0.0590664486148222 1.05870108457635 0.456140350877193 1.1 1 1 abnormal embryonic tissue morphology 5.35159674628706e-05 0.000978830654881549 1.05787007901545 0.45578231292517 1.1 1 1 increased sensitivity to xenobiotic induced morbidity/mortality 0.000481992664642395 0.00572294392982318 1.05499933253237 0.454545454545455 1.1 1 1 decreased circulating calcium level 0.0115814210226658 0.0644491829840741 1.05499933253237 0.454545454545455 1.1 1 1 abnormal photoreceptor outer segment morphology 0.0225732641435659 0.110533453852599 1.05499933253237 0.454545454545455 1.1 1 1 cochlear hair cell degeneration 0.0225732641435659 0.110533453852599 1.05499933253237 0.454545454545455 1.1 1 1 abnormal enterocyte morphology 0.093502639321021 0.263705006021587 1.05499933253237 0.454545454545455 1.1 1 1 increased body size 0.093502639321021 0.263705006021587 1.05499933253237 0.454545454545455 1.1 1 1 abnormal germ layer development 0.093502639321021 0.263705006021587 1.05499933253237 0.454545454545455 1.1 1 1 testis hypoplasia 0.093502639321021 0.263705006021587 1.05499933253237 0.454545454545455 1.1 1 1 abnormal tracheal cartilage morphology 0.093502639321021 0.263705006021587 1.05499933253237 0.454545454545455 1.1 1 1 decreased cardiac output 0.093502639321021 0.263705006021587 1.05499933253237 0.454545454545455 1.1 1 1 pulmonary vascular congestion 0.093502639321021 0.263705006021587 1.05499933253237 0.454545454545455 1.1 1 1 increased mammary gland tumor incidence 0.093502639321021 0.263705006021587 1.05499933253237 0.454545454545455 1.1 1 1 abnormal ear position 0.212731691187723 0.454053433148469 1.05499933253237 0.454545454545455 1.1 1 1 abnormal awl hair morphology 0.212731691187723 0.454053433148469 1.05499933253237 0.454545454545455 1.1 1 1 enlarged cranium 0.212731691187723 0.454053433148469 1.05499933253237 0.454545454545455 1.1 1 1 abnormal stomach epithelium morphology 0.212731691187723 0.454053433148469 1.05499933253237 0.454545454545455 1.1 1 1 delayed hepatic development 0.212731691187723 0.454053433148469 1.05499933253237 0.454545454545455 1.1 1 1 abnormal enteric ganglia morphology 0.212731691187723 0.454053433148469 1.05499933253237 0.454545454545455 1.1 1 1 abnormal glossopharyngeal ganglion morphology 0.212731691187723 0.454053433148469 1.05499933253237 0.454545454545455 1.1 1 1 abnormal eye distance/ position 0.212731691187723 0.454053433148469 1.05499933253237 0.454545454545455 1.1 1 1 abnormal food preference 0.212731691187723 0.454053433148469 1.05499933253237 0.454545454545455 1.1 1 1 abnormal hemoglobin 0.212731691187723 0.454053433148469 1.05499933253237 0.454545454545455 1.1 1 1 focal hepatic necrosis 0.212731691187723 0.454053433148469 1.05499933253237 0.454545454545455 1.1 1 1 vasculitis 0.212731691187723 0.454053433148469 1.05499933253237 0.454545454545455 1.1 1 1 secondary sex reversal 0.212731691187723 0.454053433148469 1.05499933253237 0.454545454545455 1.1 1 1 abnormal fear/anxiety-related behavior 0.212731691187723 0.454053433148469 1.05499933253237 0.454545454545455 1.1 1 1 abnormal primary sex determination 0.212731691187723 0.454053433148469 1.05499933253237 0.454545454545455 1.1 1 1 abnormal larynx morphology 0.212731691187723 0.454053433148469 1.05499933253237 0.454545454545455 1.1 1 1 decreased post-tetanic potentiation 0.212731691187723 0.454053433148469 1.05499933253237 0.454545454545455 1.1 1 1 variable body spotting 0.212731691187723 0.454053433148469 1.05499933253237 0.454545454545455 1.1 1 1 patent ductus arteriosus 0.212731691187723 0.454053433148469 1.05499933253237 0.454545454545455 1.1 1 1 fused joints 0.212731691187723 0.454053433148469 1.05499933253237 0.454545454545455 1.1 1 1 abnormal frequency of paradoxical sleep 0.212731691187723 0.454053433148469 1.05499933253237 0.454545454545455 1.1 1 1 impaired luteinization 0.212731691187723 0.454053433148469 1.05499933253237 0.454545454545455 1.1 1 1 abnormal radial glial cell morphology 0.212731691187723 0.454053433148469 1.05499933253237 0.454545454545455 1.1 1 1 abnormal lymph circulation 0.212731691187723 0.454053433148469 1.05499933253237 0.454545454545455 1.1 1 1 abnormal pituitary gland development 0.212731691187723 0.454053433148469 1.05499933253237 0.454545454545455 1.1 1 1 pharyngeal arch hypoplasia 0.212731691187723 0.454053433148469 1.05499933253237 0.454545454545455 1.1 1 1 abnormal dorsal-ventral polarity of the somites 0.212731691187723 0.454053433148469 1.05499933253237 0.454545454545455 1.1 1 1 abnormal Bruch membrane morphology 0.212731691187723 0.454053433148469 1.05499933253237 0.454545454545455 1.1 1 1 abnormal platelet aggregation 0.212731691187723 0.454053433148469 1.05499933253237 0.454545454545455 1.1 1 1 aberrant origin of the right subclavian artery 0.212731691187723 0.454053433148469 1.05499933253237 0.454545454545455 1.1 1 1 shortened PR interval 0.212731691187723 0.454053433148469 1.05499933253237 0.454545454545455 1.1 1 1 abnormal extraembryonic ectoderm morphology 0.212731691187723 0.454053433148469 1.05499933253237 0.454545454545455 1.1 1 1 abnormal dendritic cell chemotaxis 0.212731691187723 0.454053433148469 1.05499933253237 0.454545454545455 1.1 1 1 abnormal brain ependyma motile cilium morphology 0.212731691187723 0.454053433148469 1.05499933253237 0.454545454545455 1.1 1 1 abnormal phrenic nerve innervation pattern to diaphragm 0.212731691187723 0.454053433148469 1.05499933253237 0.454545454545455 1.1 1 1 chylous ascites 0.212731691187723 0.454053433148469 1.05499933253237 0.454545454545455 1.1 1 1 abnormal tooth development 0.0450254020354148 0.176657235903934 1.05499933253237 0.454545454545455 1.1 1 1 dextrocardia 0.0450254020354148 0.176657235903934 1.05499933253237 0.454545454545455 1.1 1 1 decreased systemic arterial blood pressure 0.0450254020354148 0.176657235903934 1.05499933253237 0.454545454545455 1.1 1 1 single kidney 0.0450254020354148 0.176657235903934 1.05499933253237 0.454545454545455 1.1 1 1 abnormal middle ear ossicle morphology 0.0450254020354148 0.176657235903934 1.05499933253237 0.454545454545455 1.1 1 1 abnormal osteoclast physiology 0.00723991111226586 0.0490716046097039 1.05170245961821 0.453125 1.1 1 1 decreased exploration in new environment 0.00240746759906915 0.0216194066883918 1.04997552618698 0.452380952380952 1.1 1 1 abnormal spleen white pulp morphology 0.027299337596323 0.122797653292683 1.04997552618698 0.452380952380952 1.1 1 1 abnormal cytotoxic T cell physiology 0.027299337596323 0.122797653292683 1.04997552618698 0.452380952380952 1.1 1 1 hydroencephaly 0.000438953693705161 0.00539208549674858 1.04949498818872 0.452173913043478 1.1 1 1 astrocytosis 0.00455376073736012 0.0333651836058418 1.04921851427192 0.452054794520548 1.1 1 1 autoimmune response 0.0548461763720094 0.203474815399513 1.04819288522571 0.451612903225806 1.1 1 1 abnormal T cell proliferation 0.0548461763720094 0.203474815399513 1.04819288522571 0.451612903225806 1.1 1 1 abnormal mitochondrial ATP synthesis coupled electron transport 0.0548461763720094 0.203474815399513 1.04819288522571 0.451612903225806 1.1 1 1 abnormal social investigation 0.00344074087483204 0.0277884510589114 1.04444933920705 0.45 1.1 1 1 epidermal hyperplasia 0.0104336071572074 0.0626898497670374 1.04444933920705 0.45 1.1 1 1 abnormal pericardium morphology 0.11546326117579 0.311006889198461 1.04444933920705 0.45 1.1 1 1 increased urine glucose level 0.11546326117579 0.311006889198461 1.04444933920705 0.45 1.1 1 1 abnormal hair texture 0.11546326117579 0.311006889198461 1.04444933920705 0.45 1.1 1 1 abnormal trachea morphology 0.11546326117579 0.311006889198461 1.04444933920705 0.45 1.1 1 1 abnormal heart right ventricle morphology 0.11546326117579 0.311006889198461 1.04444933920705 0.45 1.1 1 1 abnormal optic stalk morphology 0.11546326117579 0.311006889198461 1.04444933920705 0.45 1.1 1 1 abnormal renal glomerulus morphology 0.000742044615090896 0.00816741584087878 1.04338466098156 0.44954128440367 1.1 1 1 hyperkeratosis 0.00653194037990401 0.04500886896125 1.04276745621316 0.449275362318841 1.1 1 1 increased sarcoma incidence 0.0202274080122622 0.102580382121309 1.04208097335851 0.448979591836735 1.1 1 1 increased embryonic tissue cell apoptosis 0.00411313896393493 0.0314329744171679 1.04147370006401 0.448717948717949 1.1 1 1 decreased retinal photoreceptor cell number 0.0668917141162175 0.232880530250652 1.04044761760089 0.448275862068966 1.1 1 1 aphagia 0.0668917141162175 0.232880530250652 1.04044761760089 0.448275862068966 1.1 1 1 abnormal CD8-positive, alpha-beta T cell physiology 0.0668917141162175 0.232880530250652 1.04044761760089 0.448275862068966 1.1 1 1 decreased bone strength 0.0668917141162175 0.232880530250652 1.04044761760089 0.448275862068966 1.1 1 1 rib fusion 0.00782328382743292 0.0521028608319663 1.03925307383786 0.447761194029851 1.1 1 1 spleen hypoplasia 0.00105241271865149 0.0110692458251399 1.03892315222712 0.447619047619048 1.1 1 1 abnormal axial skeleton morphology 0.00491670004206004 0.0358659570516843 1.03834144833449 0.447368421052632 1.1 1 1 increased systemic arterial blood pressure 0.0243730402949093 0.11876187606971 1.03704189708501 0.446808510638298 1.1 1 1 abnormal craniofacial morphology 0.00125307793818241 0.0128537376133145 1.03656245099297 0.446601941747573 1.1 1 1 increased body weight 2.91725389081521e-06 8.63889173024146e-05 1.03616005873715 0.446428571428571 1.1 1 1 abnormal eye development 0.0150429457286459 0.0801270396145751 1.03616005873715 0.446428571428571 1.1 1 1 abnormal enzyme/coenzyme activity 8.70321073558392e-05 0.00147298451912628 1.03484010961774 0.445859872611465 1.1 1 1 increased circulating aspartate transaminase level 0.0112224187489087 0.0638804728556299 1.03155490292054 0.444444444444444 1.1 1 1 albuminuria 0.0293768703293194 0.128766458051422 1.03155490292054 0.444444444444444 1.1 1 1 lethality at weaning, complete penetrance 0.0293768703293194 0.128766458051422 1.03155490292054 0.444444444444444 1.1 1 1 abnormal palate morphology 0.0816941071781977 0.256862964844569 1.03155490292054 0.444444444444444 1.1 1 1 abnormal bone trabecula morphology 0.0816941071781977 0.256862964844569 1.03155490292054 0.444444444444444 1.1 1 1 abnormal heart left ventricle morphology 0.00702414124895317 0.0477392113572978 1.03155490292054 0.444444444444444 1.1 1 1 abnormal megakaryocyte differentiation 0.143044715522251 0.364014045894219 1.03155490292054 0.444444444444444 1.1 1 1 abnormal stomach glandular epithelium morphology 0.143044715522251 0.364014045894219 1.03155490292054 0.444444444444444 1.1 1 1 abnormal radius morphology 0.143044715522251 0.364014045894219 1.03155490292054 0.444444444444444 1.1 1 1 abnormal phrenic nerve morphology 0.143044715522251 0.364014045894219 1.03155490292054 0.444444444444444 1.1 1 1 blepharoptosis 0.143044715522251 0.364014045894219 1.03155490292054 0.444444444444444 1.1 1 1 eye inflammation 0.143044715522251 0.364014045894219 1.03155490292054 0.444444444444444 1.1 1 1 abnormal thymus medulla morphology 0.143044715522251 0.364014045894219 1.03155490292054 0.444444444444444 1.1 1 1 increased circulating glycerol level 0.143044715522251 0.364014045894219 1.03155490292054 0.444444444444444 1.1 1 1 absent inner cell mass 0.143044715522251 0.364014045894219 1.03155490292054 0.444444444444444 1.1 1 1 jerky movement 0.143044715522251 0.364014045894219 1.03155490292054 0.444444444444444 1.1 1 1 abnormal glycogen homeostasis 0.143044715522251 0.364014045894219 1.03155490292054 0.444444444444444 1.1 1 1 decreased lactate dehydrogenase level 0.143044715522251 0.364014045894219 1.03155490292054 0.444444444444444 1.1 1 1 decreased pulmonary respiratory rate 0.143044715522251 0.364014045894219 1.03155490292054 0.444444444444444 1.1 1 1 small thoracic cage 0.143044715522251 0.364014045894219 1.03155490292054 0.444444444444444 1.1 1 1 abnormal aerobic respiration 0.143044715522251 0.364014045894219 1.03155490292054 0.444444444444444 1.1 1 1 abnormal skeleton morphology 0.000857866899156801 0.009257891156844 1.02931239226202 0.443478260869565 1.1 1 1 decreased IgM level 0.00211328789450721 0.0193264839617158 1.02889625626353 0.443298969072165 1.1 1 1 increased circulating cholesterol level 4.59479867078668e-05 0.000866098936993236 1.02862434921906 0.443181818181818 1.1 1 1 short femur 0.00333242613910012 0.0269758606548673 1.02862434921906 0.443181818181818 1.1 1 1 hunched posture 0.00527598930030355 0.0381512307689101 1.02829048867079 0.443037974683544 1.1 1 1 cachexia 0.0015984146867628 0.015778002116359 1.02659550434881 0.442307692307692 1.1 1 1 decreased body temperature 0.0216975988925327 0.108209565713272 1.02659550434881 0.442307692307692 1.1 1 1 abnormal blood circulation 0.0354184405927376 0.144787791248044 1.02555749069426 0.441860465116279 1.1 1 1 obese 0.00629385345388251 0.0434284617656941 1.02485649446002 0.441558441558442 1.1 1 1 abnormal nervous system development 0.0587485841990627 0.210817112428594 1.02396994039907 0.441176470588235 1.1 1 1 abnormal direction of heart looping 0.0587485841990627 0.210817112428594 1.02396994039907 0.441176470588235 1.1 1 1 decreased osteoblast cell number 0.0587485841990627 0.210817112428594 1.02396994039907 0.441176470588235 1.1 1 1 syndactyly 0.0160973821488738 0.0841223489397551 1.02281291221783 0.440677966101695 1.1 1 1 increased hemoglobin content 0.0160973821488738 0.0841223489397551 1.02281291221783 0.440677966101695 1.1 1 1 abnormal inner ear vestibule morphology 0.0999227832322783 0.274064748021059 1.02123935389134 0.44 1.1 1 1 abnormal feces composition 0.0999227832322783 0.274064748021059 1.02123935389134 0.44 1.1 1 1 decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 0.0999227832322783 0.274064748021059 1.02123935389134 0.44 1.1 1 1 increased liver glycogen level 0.0999227832322783 0.274064748021059 1.02123935389134 0.44 1.1 1 1 increased thermal nociceptive threshold 0.00355825223127394 0.0285521045977223 1.02021913475658 0.43956043956044 1.1 1 1 increased tumor growth/size 0.0427151572477337 0.168389783920345 1.01897496508005 0.439024390243902 1.1 1 1 decreased rib number 0.00423133618446265 0.0321879166937335 1.01706677226155 0.438202247191011 1.1 1 1 abnormal neuron differentiation 0.00152950729803448 0.0151882211730968 1.01543685756241 0.4375 1.1 1 1 retinal degeneration 0.00318533603716722 0.0260642216857022 1.01543685756241 0.4375 1.1 1 1 oligodactyly 0.0313067550251157 0.13244141687921 1.01543685756241 0.4375 1.1 1 1 scoliosis 0.0712758141086685 0.238841492273665 1.01543685756241 0.4375 1.1 1 1 pancreatic islet hyperplasia 0.0712758141086685 0.238841492273665 1.01543685756241 0.4375 1.1 1 1 abnormal intestinal absorption 0.177896806338811 0.420045852650966 1.01543685756241 0.4375 1.1 1 1 abnormal meiosis 0.177896806338811 0.420045852650966 1.01543685756241 0.4375 1.1 1 1 paternal imprinting 0.177896806338811 0.420045852650966 1.01543685756241 0.4375 1.1 1 1 decreased cochlear coiling 0.177896806338811 0.420045852650966 1.01543685756241 0.4375 1.1 1 1 impaired muscle relaxation 0.177896806338811 0.420045852650966 1.01543685756241 0.4375 1.1 1 1 abnormal level of surface class II molecules 0.177896806338811 0.420045852650966 1.01543685756241 0.4375 1.1 1 1 abnormal Langerhans cell physiology 0.177896806338811 0.420045852650966 1.01543685756241 0.4375 1.1 1 1 impaired somite development 0.177896806338811 0.420045852650966 1.01543685756241 0.4375 1.1 1 1 decreased liver cholesterol level 0.177896806338811 0.420045852650966 1.01543685756241 0.4375 1.1 1 1 abnormal thoracic cage shape 0.177896806338811 0.420045852650966 1.01543685756241 0.4375 1.1 1 1 abnormal urinary bladder physiology 0.177896806338811 0.420045852650966 1.01543685756241 0.4375 1.1 1 1 dilated respiratory conducting tubes 0.177896806338811 0.420045852650966 1.01543685756241 0.4375 1.1 1 1 decreased fibroblast apoptosis 0.177896806338811 0.420045852650966 1.01543685756241 0.4375 1.1 1 1 increased circulating calcium level 0.0230855305572394 0.112709042710762 1.01279935923108 0.436363636363636 1.1 1 1 acanthosis 0.0515302387586581 0.192032163164288 1.01171730863361 0.435897435897436 1.1 1 1 increased hepatocyte apoptosis 0.0515302387586581 0.192032163164288 1.01171730863361 0.435897435897436 1.1 1 1 abnormal response to injury 0.0515302387586581 0.192032163164288 1.01171730863361 0.435897435897436 1.1 1 1 circling 0.00597909277986453 0.0424336470468274 1.01031700786041 0.435294117647059 1.1 1 1 abnormal coat appearance 0.012723546784124 0.0692556293774802 1.00912979633531 0.434782608695652 1.1 1 1 abnormal immune system morphology 0.0376088218225887 0.153112838434844 1.00912979633531 0.434782608695652 1.1 1 1 abnormal blood vessel physiology 0.122423657338782 0.32604801673471 1.00912979633531 0.434782608695652 1.1 1 1 abnormal innervation pattern to muscle 0.122423657338782 0.32604801673471 1.00912979633531 0.434782608695652 1.1 1 1 conjunctivitis 0.122423657338782 0.32604801673471 1.00912979633531 0.434782608695652 1.1 1 1 abnormal cochlear ganglion morphology 0.122423657338782 0.32604801673471 1.00912979633531 0.434782608695652 1.1 1 1 increased neutrophil cell number 0.00045148299118692 0.00550521539498757 1.00843384475163 0.43448275862069 1.1 1 1 abnormal long bone epiphyseal plate morphology 0.0204285042013246 0.103494713239908 1.00576603034753 0.433333333333333 1.1 1 1 delayed eyelid opening 0.0865391866374049 0.256862964844569 1.00576603034753 0.433333333333333 1.1 1 1 salivary gland inflammation 0.0865391866374049 0.256862964844569 1.00576603034753 0.433333333333333 1.1 1 1 abnormal pain threshold 0.0865391866374049 0.256862964844569 1.00576603034753 0.433333333333333 1.1 1 1 increased circulating phosphate level 0.062182248784944 0.220026093673611 1.00367504067945 0.432432432432432 1.1 1 1 decreased width of hypertrophic chondrocyte zone 0.062182248784944 0.220026093673611 1.00367504067945 0.432432432432432 1.1 1 1 decreased sensitivity to induced morbidity/mortality 0.0451807746941081 0.177127150593528 1.00224936590575 0.431818181818182 1.1 1 1 increased kidney weight 0.0330948110137182 0.137190295920277 1.00121505283464 0.431372549019608 1.1 1 1 cochlear inner hair cell degeneration 0.0330948110137182 0.137190295920277 1.00121505283464 0.431372549019608 1.1 1 1 failure of chorioallantoic fusion 0.0330948110137182 0.137190295920277 1.00121505283464 0.431372549019608 1.1 1 1 abnormal vertebrae morphology 0.00268780045801758 0.0229756138808204 1.0007975319619 0.431192660550459 1.1 1 1 abnormal visceral yolk sac morphology 0.010021188753758 0.0605041432644979 0.998910760423056 0.430379746835443 1.1 1 1 abnormal eye electrophysiology 0.00180812375652931 0.0169405191878217 0.997453914394243 0.429752066115702 1.1 1 1 abnormal seminal vesicle morphology 0.0291174691786845 0.128432047530706 0.994713656387665 0.428571428571429 1.1 1 1 abnormal pancreas morphology 0.054277021986292 0.201814786533485 0.994713656387665 0.428571428571429 1.1 1 1 increased circulating serum albumin level 0.0750564542278792 0.249667084915636 0.994713656387665 0.428571428571429 1.1 1 1 abnormal hippocampus pyramidal cell morphology 0.0750564542278792 0.249667084915636 0.994713656387665 0.428571428571429 1.1 1 1 abnormal jaw morphology 0.105153511284718 0.286808508027122 0.994713656387665 0.428571428571429 1.1 1 1 reddish skin 0.105153511284718 0.286808508027122 0.994713656387665 0.428571428571429 1.1 1 1 abnormal respiration 0.105153511284718 0.286808508027122 0.994713656387665 0.428571428571429 1.1 1 1 straub tail 0.105153511284718 0.286808508027122 0.994713656387665 0.428571428571429 1.1 1 1 failure of blastocyst to hatch from the zona pellucida 0.105153511284718 0.286808508027122 0.994713656387665 0.428571428571429 1.1 1 1 increased incidence of induced tumors 0.150270692814044 0.380957762867829 0.994713656387665 0.428571428571429 1.1 1 1 abnormal embryonic/fetal subventricular zone morphology 0.150270692814044 0.380957762867829 0.994713656387665 0.428571428571429 1.1 1 1 increased keratinocyte proliferation 0.150270692814044 0.380957762867829 0.994713656387665 0.428571428571429 1.1 1 1 complete atrioventricular septal defect 0.150270692814044 0.380957762867829 0.994713656387665 0.428571428571429 1.1 1 1 midline facial cleft 0.222264148809865 0.462469318414504 0.994713656387665 0.428571428571429 1.1 1 1 abnormal placing response 0.222264148809865 0.462469318414504 0.994713656387665 0.428571428571429 1.1 1 1 absent otoliths 0.222264148809865 0.462469318414504 0.994713656387665 0.428571428571429 1.1 1 1 abnormal prepulse inhibition 0.222264148809865 0.462469318414504 0.994713656387665 0.428571428571429 1.1 1 1 abnormal imprinting 0.222264148809865 0.462469318414504 0.994713656387665 0.428571428571429 1.1 1 1 abnormal decidualization 0.222264148809865 0.462469318414504 0.994713656387665 0.428571428571429 1.1 1 1 skeletal muscle necrosis 0.222264148809865 0.462469318414504 0.994713656387665 0.428571428571429 1.1 1 1 abnormal iris pigmentation 0.222264148809865 0.462469318414504 0.994713656387665 0.428571428571429 1.1 1 1 abnormal renal reabsorbtion 0.222264148809865 0.462469318414504 0.994713656387665 0.428571428571429 1.1 1 1 abnormal response/metabolism to endogenous compounds 0.0105307548521775 0.0631972320742857 0.990670104938935 0.426829268292683 1.1 1 1 abnormal inhibitory postsynaptic currents 0.0189791629148699 0.0966441509738769 0.989837609052431 0.426470588235294 1.1 1 1 abnormal male meiosis 0.0256193169274443 0.122355018309237 0.989278062636913 0.426229508196721 1.1 1 1 polyphagia 0.0347479098447933 0.142163529175861 0.988573448632186 0.425925925925926 1.1 1 1 abnormal tibia morphology 0.0474131044356846 0.183412212087438 0.987658949604774 0.425531914893617 1.1 1 1 abnormal T-helper 1 physiology 0.0474131044356846 0.183412212087438 0.987658949604774 0.425531914893617 1.1 1 1 short limbs 0.00932100360142164 0.0578926253646351 0.987091329518794 0.425287356321839 1.1 1 1 perinatal lethality 0.0652016704102324 0.22779375722676 0.986424375917768 0.425 1.1 1 1 abnormal pancreatic beta cell morphology 0.0652016704102324 0.22779375722676 0.986424375917768 0.425 1.1 1 1 increased susceptibility to weight loss 0.0652016704102324 0.22779375722676 0.986424375917768 0.425 1.1 1 1 diarrhea 0.0906182230047504 0.256862964844569 0.984666043696881 0.424242424242424 1.1 1 1 abnormal gait 2.90190497658594e-06 8.63889173024146e-05 0.983983196232458 0.423948220064725 1.1 1 1 abnormal stomach morphology 0.127875179001808 0.331515901789472 0.981960917203208 0.423076923076923 1.1 1 1 heart inflammation 0.127875179001808 0.331515901789472 0.981960917203208 0.423076923076923 1.1 1 1 abnormal tectorial membrane morphology 0.127875179001808 0.331515901789472 0.981960917203208 0.423076923076923 1.1 1 1 abnormal rib morphology 0.00185087033517798 0.0171153901812462 0.979977157774515 0.422222222222222 1.1 1 1 decreased eosinophil cell number 0.0267695063875468 0.122797653292683 0.979171255506608 0.421875 1.1 1 1 abnormal frontal bone morphology 0.0783174265795173 0.256862964844569 0.977262539608934 0.421052631578947 1.1 1 1 decreased neuron apoptosis 0.0783174265795173 0.256862964844569 0.977262539608934 0.421052631578947 1.1 1 1 shiny skin 0.184833957497728 0.434364165588662 0.977262539608934 0.421052631578947 1.1 1 1 abnormal long term depression 0.184833957497728 0.434364165588662 0.977262539608934 0.421052631578947 1.1 1 1 abnormal neurotransmitter level 0.184833957497728 0.434364165588662 0.977262539608934 0.421052631578947 1.1 1 1 abnormal response to novelty 0.184833957497728 0.434364165588662 0.977262539608934 0.421052631578947 1.1 1 1 abnormal digestive system development 0.184833957497728 0.434364165588662 0.977262539608934 0.421052631578947 1.1 1 1 maternal imprinting 0.184833957497728 0.434364165588662 0.977262539608934 0.421052631578947 1.1 1 1 abnormal sternebra morphology 0.184833957497728 0.434364165588662 0.977262539608934 0.421052631578947 1.1 1 1 abnormal cochlear inner hair cell morphology 0.184833957497728 0.434364165588662 0.977262539608934 0.421052631578947 1.1 1 1 abnormal behavioral response to xenobiotic 0.184833957497728 0.434364165588662 0.977262539608934 0.421052631578947 1.1 1 1 thin interventricular septum 0.184833957497728 0.434364165588662 0.977262539608934 0.421052631578947 1.1 1 1 abnormal epidermal layer morphology 0.0235144846096607 0.114690746012806 0.975492136457469 0.420289855072464 1.1 1 1 abnormal axon extension 0.0494313543398199 0.186445024898108 0.974819383259912 0.42 1.1 1 1 abnormal skeleton development 0.0153918949724692 0.0817267422537152 0.974246297202734 0.419753086419753 1.1 1 1 abnormal retinal photoreceptor layer morphology 0.109428582940191 0.296356668550598 0.973321964852447 0.419354838709677 1.1 1 1 inner cell mass degeneration 0.109428582940191 0.296356668550598 0.973321964852447 0.419354838709677 1.1 1 1 decreased double-negative T cell number 0.109428582940191 0.296356668550598 0.973321964852447 0.419354838709677 1.1 1 1 abnormal left-right axis patterning 0.0678552005896511 0.236069666387073 0.971580780657719 0.418604651162791 1.1 1 1 abnormal T-helper 2 physiology 0.0431302449577226 0.169891503297442 0.970599385929782 0.418181818181818 1.1 1 1 abnormal locomotor activation 0.0119540084152367 0.0658708598868335 0.969208178018751 0.417582417582418 1.1 1 1 increased food intake 0.0159878682946177 0.0837259418586559 0.967082721488008 0.416666666666667 1.1 1 1 abnormal pharyngeal arch morphology 0.0940555952034483 0.264964091810394 0.967082721488008 0.416666666666667 1.1 1 1 head tilt 0.0940555952034483 0.264964091810394 0.967082721488008 0.416666666666667 1.1 1 1 abnormal vasodilation 0.155634195139655 0.388448889001793 0.967082721488008 0.416666666666667 1.1 1 1 decreased ovulation rate 0.155634195139655 0.388448889001793 0.967082721488008 0.416666666666667 1.1 1 1 decreased fatty acid level 0.155634195139655 0.388448889001793 0.967082721488008 0.416666666666667 1.1 1 1 increased circulating total protein level 0.155634195139655 0.388448889001793 0.967082721488008 0.416666666666667 1.1 1 1 abnormal cellular extravasation 0.155634195139655 0.388448889001793 0.967082721488008 0.416666666666667 1.1 1 1 abnormal inner cell mass apoptosis 0.155634195139655 0.388448889001793 0.967082721488008 0.416666666666667 1.1 1 1 absent optic nerve 0.279266497993985 0.496698746879043 0.967082721488008 0.416666666666667 1.1 1 1 abnormal pilomotor reflex 0.279266497993985 0.496698746879043 0.967082721488008 0.416666666666667 1.1 1 1 ear inflammation 0.279266497993985 0.496698746879043 0.967082721488008 0.416666666666667 1.1 1 1 abnormal tracheal ciliated epithelium morphology 0.279266497993985 0.496698746879043 0.967082721488008 0.416666666666667 1.1 1 1 increased circulating parathyroid hormone level 0.279266497993985 0.496698746879043 0.967082721488008 0.416666666666667 1.1 1 1 small thyroid gland 0.279266497993985 0.496698746879043 0.967082721488008 0.416666666666667 1.1 1 1 impaired sperm capacitation 0.279266497993985 0.496698746879043 0.967082721488008 0.416666666666667 1.1 1 1 delayed somite formation 0.279266497993985 0.496698746879043 0.967082721488008 0.416666666666667 1.1 1 1 abnormal anogenital distance 0.279266497993985 0.496698746879043 0.967082721488008 0.416666666666667 1.1 1 1 abnormal amacrine cell morphology 0.279266497993985 0.496698746879043 0.967082721488008 0.416666666666667 1.1 1 1 abnormal palatine bone morphology 0.279266497993985 0.496698746879043 0.967082721488008 0.416666666666667 1.1 1 1 abnormal fatty acid level 0.279266497993985 0.496698746879043 0.967082721488008 0.416666666666667 1.1 1 1 abnormal patella morphology 0.279266497993985 0.496698746879043 0.967082721488008 0.416666666666667 1.1 1 1 abnormal thymus corticomedullary boundary morphology 0.279266497993985 0.496698746879043 0.967082721488008 0.416666666666667 1.1 1 1 hydrometra 0.279266497993985 0.496698746879043 0.967082721488008 0.416666666666667 1.1 1 1 reduced cerebellar foliation 0.279266497993985 0.496698746879043 0.967082721488008 0.416666666666667 1.1 1 1 abnormal behavioral response to addictive substance 0.279266497993985 0.496698746879043 0.967082721488008 0.416666666666667 1.1 1 1 impaired behavioral response to cocaine 0.279266497993985 0.496698746879043 0.967082721488008 0.416666666666667 1.1 1 1 decreased oligodendrocyte number 0.279266497993985 0.496698746879043 0.967082721488008 0.416666666666667 1.1 1 1 abnormal aorta elastic tissue morphology 0.279266497993985 0.496698746879043 0.967082721488008 0.416666666666667 1.1 1 1 decreased mammary gland epithelial cell proliferation 0.279266497993985 0.496698746879043 0.967082721488008 0.416666666666667 1.1 1 1 abnormal colon goblet cell morphology 0.279266497993985 0.496698746879043 0.967082721488008 0.416666666666667 1.1 1 1 abnormal vitelline vein connection 0.279266497993985 0.496698746879043 0.967082721488008 0.416666666666667 1.1 1 1 scaly skin 0.081129617233669 0.256862964844569 0.962365244797822 0.414634146341463 1.1 1 1 abnormal circulating glucose level 0.132161838697777 0.342272330828443 0.960413185477746 0.413793103448276 1.1 1 1 stomach inflammation 0.132161838697777 0.342272330828443 0.960413185477746 0.413793103448276 1.1 1 1 abnormal limb morphology 0.025282171656278 0.122352922169244 0.959346059716104 0.413333333333333 1.1 1 1 abnormal lymphocyte physiology 0.0701852720350704 0.238841492273665 0.958673306518547 0.41304347826087 1.1 1 1 increased circulating insulin level 0.00175255973321115 0.0164509144768405 0.957411894273128 0.4125 1.1 1 1 abnormal trabecular bone morphology 0.00660380062844487 0.045263559129701 0.955705277705796 0.411764705882353 1.1 1 1 abnormal response to novel object 0.0608669346680908 0.215986447912804 0.955705277705796 0.411764705882353 1.1 1 1 abnormal vision 0.112926970168732 0.30516658152604 0.955705277705796 0.411764705882353 1.1 1 1 increased width of hypertrophic chondrocyte zone 0.112926970168732 0.30516658152604 0.955705277705796 0.411764705882353 1.1 1 1 abnormal skin physiology 0.112926970168732 0.30516658152604 0.955705277705796 0.411764705882353 1.1 1 1 increased susceptibility to viral infection induced morbidity/mortality 0.112926970168732 0.30516658152604 0.955705277705796 0.411764705882353 1.1 1 1 abnormal adipose tissue morphology 0.227869071270607 0.472156863628183 0.955705277705796 0.411764705882353 1.1 1 1 abnormal urinary bladder morphology 0.227869071270607 0.472156863628183 0.955705277705796 0.411764705882353 1.1 1 1 increased incidence of corneal inflammation 0.227869071270607 0.472156863628183 0.955705277705796 0.411764705882353 1.1 1 1 abnormal dorsal-ventral axis patterning 0.227869071270607 0.472156863628183 0.955705277705796 0.411764705882353 1.1 1 1 abnormal melanosome morphology 0.227869071270607 0.472156863628183 0.955705277705796 0.411764705882353 1.1 1 1 pancytopenia 0.227869071270607 0.472156863628183 0.955705277705796 0.411764705882353 1.1 1 1 increased brain size 0.227869071270607 0.472156863628183 0.955705277705796 0.411764705882353 1.1 1 1 enhanced behavioral response to cocaine 0.227869071270607 0.472156863628183 0.955705277705796 0.411764705882353 1.1 1 1 common atrium 0.227869071270607 0.472156863628183 0.955705277705796 0.411764705882353 1.1 1 1 short mandible 0.0528967250461431 0.196829623862799 0.953267254038179 0.410714285714286 1.1 1 1 small lens 0.0969519920201148 0.270823223076963 0.952204525772808 0.41025641025641 1.1 1 1 abnormal NK cell physiology 0.046053635238337 0.17969947867508 0.951228906381647 0.409836065573771 1.1 1 1 increased circulating HDL cholesterol level 0.0116306713042015 0.0646509382551984 0.950504160548213 0.40952380952381 1.1 1 1 abnormal abdominal fat pad morphology 0.189571652924599 0.443403372496417 0.949499399279135 0.409090909090909 1.1 1 1 intestinal ulcer 0.189571652924599 0.443403372496417 0.949499399279135 0.409090909090909 1.1 1 1 intracerebral hemorrhage 0.189571652924599 0.443403372496417 0.949499399279135 0.409090909090909 1.1 1 1 abnormal channel response 0.189571652924599 0.443403372496417 0.949499399279135 0.409090909090909 1.1 1 1 abnormal retinal outer plexiform layer morphology 0.189571652924599 0.443403372496417 0.949499399279135 0.409090909090909 1.1 1 1 abnormal limb posture 0.189571652924599 0.443403372496417 0.949499399279135 0.409090909090909 1.1 1 1 abnormal temporal bone morphology 0.189571652924599 0.443403372496417 0.949499399279135 0.409090909090909 1.1 1 1 decreased susceptibility to viral infection induced morbidity/mortality 0.189571652924599 0.443403372496417 0.949499399279135 0.409090909090909 1.1 1 1 impaired swimming 0.0401593642526866 0.159578943416227 0.949499399279135 0.409090909090909 1.1 1 1 abnormal respiratory system physiology 0.0722289324490808 0.241491222402001 0.947346339416824 0.408163265306122 1.1 1 1 abnormal craniofacial development 0.0722289324490808 0.241491222402001 0.947346339416824 0.408163265306122 1.1 1 1 abnormal brain commissure morphology 0.15962466588054 0.393934062966776 0.94559199434383 0.407407407407407 1.1 1 1 abnormal skin appearance 0.15962466588054 0.393934062966776 0.94559199434383 0.407407407407407 1.1 1 1 decreased bone ossification 0.15962466588054 0.393934062966776 0.94559199434383 0.407407407407407 1.1 1 1 neonatal lethality 0.135533108982811 0.348463678134101 0.942905653450808 0.40625 1.1 1 1 abnormal long term potentiation 0.135533108982811 0.348463678134101 0.942905653450808 0.40625 1.1 1 1 increased white adipose tissue amount 0.115787422306974 0.311374284311998 0.940945350636981 0.405405405405405 1.1 1 1 abnormal branching of the mammary ductal tree 0.115787422306974 0.311374284311998 0.940945350636981 0.405405405405405 1.1 1 1 abnormal vocalization 0.115787422306974 0.311374284311998 0.940945350636981 0.405405405405405 1.1 1 1 kinked neural tube 0.0740184678963351 0.2473081784985 0.937326330057607 0.403846153846154 1.1 1 1 impaired natural killer cell mediated cytotoxicity 0.0641418933328068 0.224564334504373 0.936543267125229 0.403508771929825 1.1 1 1 abnormal femur morphology 0.0484711636786162 0.184501942847066 0.935327766454073 0.402985074626866 1.1 1 1 abnormal motor capabilities/coordination/movement 0.00879032196039139 0.0549423154650439 0.931916077070262 0.401515151515151 1.1 1 1 abnormal joint morphology 0.0755820171655824 0.249667084915636 0.928399412628488 0.4 1.1 1 1 abnormal rostral-caudal axis patterning 0.0755820171655824 0.249667084915636 0.928399412628488 0.4 1.1 1 1 abnormal thyroid gland morphology 0.192775136411239 0.446394331896176 0.928399412628488 0.4 1.1 1 1 increased cellular sensitivity to ionizing radiation 0.192775136411239 0.446394331896176 0.928399412628488 0.4 1.1 1 1 abnormal posture 0.0376710089235308 0.153240612751076 0.928399412628487 0.4 1.1 1 1 abnormal incisor morphology 0.0655075417459176 0.228701768551537 0.928399412628487 0.4 1.1 1 1 impaired behavioral response to xenobiotic 0.138173980795967 0.355070017799553 0.928399412628487 0.4 1.1 1 1 abnormal heart tube morphology 0.162576940071358 0.393934062966776 0.928399412628487 0.4 1.1 1 1 gastrointestinal hemorrhage 0.162576940071358 0.393934062966776 0.928399412628487 0.4 1.1 1 1 brain inflammation 0.231081088379019 0.47643117061153 0.928399412628487 0.4 1.1 1 1 abnormal dopamine level 0.231081088379019 0.47643117061153 0.928399412628487 0.4 1.1 1 1 abnormal lens epithelium morphology 0.231081088379019 0.47643117061153 0.928399412628487 0.4 1.1 1 1 abnormal male reproductive system physiology 0.231081088379019 0.47643117061153 0.928399412628487 0.4 1.1 1 1 dilated vasculature 0.231081088379019 0.47643117061153 0.928399412628487 0.4 1.1 1 1 kidney atrophy 0.231081088379019 0.47643117061153 0.928399412628487 0.4 1.1 1 1 abnormal induced retinal neovascularization 0.231081088379019 0.47643117061153 0.928399412628487 0.4 1.1 1 1 enhanced behavioral response to xenobiotic 0.231081088379019 0.47643117061153 0.928399412628487 0.4 1.1 1 1 abnormal circulating cytokine level 0.231081088379019 0.47643117061153 0.928399412628487 0.4 1.1 1 1 decreased muscle cell glucose uptake 0.231081088379019 0.47643117061153 0.928399412628487 0.4 1.1 1 1 interdigital webbing 0.281632453764325 0.496698746879043 0.928399412628487 0.4 1.1 1 1 abnormal apical ectodermal ridge morphology 0.281632453764325 0.496698746879043 0.928399412628487 0.4 1.1 1 1 abnormal respiratory system morphology 0.281632453764325 0.496698746879043 0.928399412628487 0.4 1.1 1 1 arthritis 0.281632453764325 0.496698746879043 0.928399412628487 0.4 1.1 1 1 dilated ureter 0.281632453764325 0.496698746879043 0.928399412628487 0.4 1.1 1 1 abnormal rostral migratory stream morphology 0.281632453764325 0.496698746879043 0.928399412628487 0.4 1.1 1 1 abnormal trophectoderm morphology 0.281632453764325 0.496698746879043 0.928399412628487 0.4 1.1 1 1 abnormal zygomatic bone morphology 0.281632453764325 0.496698746879043 0.928399412628487 0.4 1.1 1 1 decreased trabecular bone mass 0.281632453764325 0.496698746879043 0.928399412628487 0.4 1.1 1 1 decreased brown adipose tissue mass 0.281632453764325 0.496698746879043 0.928399412628487 0.4 1.1 1 1 polydactyly 0.025733908897738 0.122355018309237 0.923662680931403 0.397959183673469 1.1 1 1 abnormal coat/ hair morphology 0.088957894447464 0.256862964844569 0.91964092760369 0.39622641509434 1.1 1 1 abnormal male reproductive system morphology 0.120007885232961 0.32030001557617 0.917604070621179 0.395348837209302 1.1 1 1 hyporesponsive to tactile stimuli 0.140224376042272 0.360152953438463 0.916183630883376 0.394736842105263 1.1 1 1 abnormal neuron morphology 0.0303976559410003 0.132072929200835 0.914332754861389 0.393939393939394 1.1 1 1 abnormal aorta morphology 0.164727784868551 0.394000350827424 0.914332754861389 0.393939393939394 1.1 1 1 absent vibrissae 0.164727784868551 0.394000350827424 0.914332754861389 0.393939393939394 1.1 1 1 decreased inflammatory response 0.0454343246493655 0.177422107637828 0.911820851688693 0.392857142857143 1.1 1 1 increased circulating luteinizing hormone level 0.194870707089602 0.446394331896176 0.911820851688693 0.392857142857143 1.1 1 1 abnormal spleen germinal center morphology 0.194870707089602 0.446394331896176 0.911820851688693 0.392857142857143 1.1 1 1 decreased food intake 0.052072953668438 0.193909389596167 0.910771575679845 0.392405063291139 1.1 1 1 impaired hematopoiesis 0.104563048943747 0.28598195079447 0.910195502576949 0.392156862745098 1.1 1 1 fragile skeleton 0.232738221515482 0.478064678794188 0.908216816701781 0.391304347826087 1.1 1 1 blistering 0.232738221515482 0.478064678794188 0.908216816701781 0.391304347826087 1.1 1 1 hypotension 0.232738221515482 0.478064678794188 0.908216816701781 0.391304347826087 1.1 1 1 failure of embryo implantation 0.232738221515482 0.478064678794188 0.908216816701781 0.391304347826087 1.1 1 1 pancreas inflammation 0.232738221515482 0.478064678794188 0.908216816701781 0.391304347826087 1.1 1 1 abnormal crista ampullaris morphology 0.232738221515482 0.478064678794188 0.908216816701781 0.391304347826087 1.1 1 1 abnormal ulna morphology 0.232738221515482 0.478064678794188 0.908216816701781 0.391304347826087 1.1 1 1 abnormal palatal shelf fusion at midline 0.232738221515482 0.478064678794188 0.908216816701781 0.391304347826087 1.1 1 1 abnormal hepatocyte physiology 0.232738221515482 0.478064678794188 0.908216816701781 0.391304347826087 1.1 1 1 abnormal tooth morphology 0.0791473037466872 0.256862964844569 0.906640051395007 0.390625 1.1 1 1 abnormal cochlea morphology 0.105730267461572 0.288223605819901 0.902610540055474 0.388888888888889 1.1 1 1 abnormal systemic arterial blood pressure 0.166249317082115 0.397257614065092 0.902610540055474 0.388888888888889 1.1 1 1 narrow eye opening 0.166249317082115 0.397257614065092 0.902610540055474 0.388888888888889 1.1 1 1 abnormal mammary gland morphology 0.281848206746833 0.496698746879043 0.902610540055474 0.388888888888889 1.1 1 1 thick dermal layer 0.281848206746833 0.496698746879043 0.902610540055474 0.388888888888889 1.1 1 1 abnormal iron level 0.281848206746833 0.496698746879043 0.902610540055474 0.388888888888889 1.1 1 1 abnormal redox activity 0.281848206746833 0.496698746879043 0.902610540055474 0.388888888888889 1.1 1 1 decreased heart rate variability 0.281848206746833 0.496698746879043 0.902610540055474 0.388888888888889 1.1 1 1 abnormal sperm axoneme morphology 0.281848206746833 0.496698746879043 0.902610540055474 0.388888888888889 1.1 1 1 decreased tumor latency 0.281848206746833 0.496698746879043 0.902610540055474 0.388888888888889 1.1 1 1 decreased fluid intake 0.281848206746833 0.496698746879043 0.902610540055474 0.388888888888889 1.1 1 1 increased circulating LDL cholesterol level 0.122723764308059 0.326672406330975 0.899979022445983 0.387755102040816 1.1 1 1 increased lung adenoma incidence 0.196144323522621 0.446394331896176 0.898451044479181 0.387096774193548 1.1 1 1 abnormal nose morphology 0.196144323522621 0.446394331896176 0.898451044479181 0.387096774193548 1.1 1 1 decreased neuronal precursor cell number 0.196144323522621 0.446394331896176 0.898451044479181 0.387096774193548 1.1 1 1 decreased susceptibility to bacterial infection induced morbidity/mortality 0.196144323522621 0.446394331896176 0.898451044479181 0.387096774193548 1.1 1 1 hypertension 0.142961036640805 0.364014045894219 0.896749432652516 0.386363636363636 1.1 1 1 abnormal circadian rhythm 0.142961036640805 0.364014045894219 0.896749432652516 0.386363636363636 1.1 1 1 abnormal amino acid level 0.142961036640805 0.364014045894219 0.896749432652516 0.386363636363636 1.1 1 1 increased autoantibody level 0.16726961605612 0.398521558500081 0.892691742912007 0.384615384615385 1.1 1 1 eyelids open at birth 0.123653412098379 0.328970976037132 0.892691742912007 0.384615384615385 1.1 1 1 abnormal xiphoid process morphology 0.233337609792133 0.478702931429221 0.892691742912007 0.384615384615385 1.1 1 1 absent common myeloid progenitor cells 0.349020920805469 0.545123720251024 0.892691742912007 0.384615384615385 1.1 1 1 absent myocardial trabeculae 0.349020920805469 0.545123720251024 0.892691742912007 0.384615384615385 1.1 1 1 abnormal mast cell morphology 0.349020920805469 0.545123720251024 0.892691742912007 0.384615384615385 1.1 1 1 tight skin 0.349020920805469 0.545123720251024 0.892691742912007 0.384615384615385 1.1 1 1 lymphoid hypoplasia 0.349020920805469 0.545123720251024 0.892691742912007 0.384615384615385 1.1 1 1 absent lateral semicircular canal 0.349020920805469 0.545123720251024 0.892691742912007 0.384615384615385 1.1 1 1 tracheoesophageal fistula 0.349020920805469 0.545123720251024 0.892691742912007 0.384615384615385 1.1 1 1 decreased alcohol consumption 0.349020920805469 0.545123720251024 0.892691742912007 0.384615384615385 1.1 1 1 muscle fatigue 0.349020920805469 0.545123720251024 0.892691742912007 0.384615384615385 1.1 1 1 decreased endocochlear potential 0.349020920805469 0.545123720251024 0.892691742912007 0.384615384615385 1.1 1 1 small pituitary gland 0.349020920805469 0.545123720251024 0.892691742912007 0.384615384615385 1.1 1 1 increased circulating glucose level 0.02278144370233 0.111333676246652 0.888893054644296 0.382978723404255 1.1 1 1 short maxilla 0.1967949558732 0.446628137573016 0.887440615012525 0.382352941176471 1.1 1 1 decreased regulatory T cell number 0.1967949558732 0.446628137573016 0.887440615012525 0.382352941176471 1.1 1 1 decreased cytotoxic T cell cytolysis 0.1967949558732 0.446628137573016 0.887440615012525 0.382352941176471 1.1 1 1 increased susceptibility to weight gain 0.1967949558732 0.446628137573016 0.887440615012525 0.382352941176471 1.1 1 1 abnormal vibrissa morphology 0.167885913669237 0.398869350766215 0.884189916789036 0.380952380952381 1.1 1 1 abnormal tumor vascularization 0.280810562572851 0.496698746879043 0.884189916789036 0.380952380952381 1.1 1 1 increased bone ossification 0.280810562572851 0.496698746879043 0.884189916789036 0.380952380952381 1.1 1 1 increased susceptibility to induced arthritis 0.233192793329052 0.478603195879551 0.8803787533546 0.379310344827586 1.1 1 1 polychromatophilia 0.233192793329052 0.478603195879551 0.8803787533546 0.379310344827586 1.1 1 1 malocclusion 0.1969652530322 0.446628137573016 0.878215660594515 0.378378378378378 1.1 1 1 skin inflammation 0.1969652530322 0.446628137573016 0.878215660594515 0.378378378378378 1.1 1 1 abnormal humerus morphology 0.1969652530322 0.446628137573016 0.878215660594515 0.378378378378378 1.1 1 1 abnormal developmental patterning 0.0826916468188805 0.256862964844569 0.877450664374485 0.378048780487805 1.1 1 1 decreased body height 0.279000637340978 0.496698746879043 0.870374449339207 0.375 1.1 1 1 abnormal nursing 0.279000637340978 0.496698746879043 0.870374449339207 0.375 1.1 1 1 decreased aggression towards mice 0.343873842219633 0.545123720251024 0.870374449339207 0.375 1.1 1 1 abnormal molar crown morphology 0.343873842219633 0.545123720251024 0.870374449339207 0.375 1.1 1 1 increased thymus weight 0.343873842219633 0.545123720251024 0.870374449339207 0.375 1.1 1 1 abnormal intestinal lipid absorption 0.343873842219633 0.545123720251024 0.870374449339207 0.375 1.1 1 1 loose skin 0.343873842219633 0.545123720251024 0.870374449339207 0.375 1.1 1 1 decreased skeletal muscle weight 0.343873842219633 0.545123720251024 0.870374449339207 0.375 1.1 1 1 decreased adipocyte glucose uptake 0.343873842219633 0.545123720251024 0.870374449339207 0.375 1.1 1 1 abnormal intestinal mucosa morphology 0.19625807866851 0.446448990112409 0.86362736058464 0.372093023255814 1.1 1 1 decreased susceptibility to pharmacologically induced seizures 0.276698165034246 0.496698746879043 0.859629085767118 0.37037037037037 1.1 1 1 decreased threshold for auditory brainstem response 0.230064097942992 0.476308317630623 0.855104722157817 0.368421052631579 1.1 1 1 irregular coat pigmentation 0.338439852142144 0.545123720251024 0.855104722157817 0.368421052631579 1.1 1 1 abnormal ear morphology 0.338439852142144 0.545123720251024 0.855104722157817 0.368421052631579 1.1 1 1 abnormal nasal septum morphology 0.338439852142144 0.545123720251024 0.855104722157817 0.368421052631579 1.1 1 1 osteoarthritis 0.338439852142144 0.545123720251024 0.855104722157817 0.368421052631579 1.1 1 1 abnormal hair cycle 0.2740756557414 0.496698746879043 0.851032794909447 0.366666666666667 1.1 1 1 arrested T cell differentiation 0.2740756557414 0.496698746879043 0.851032794909447 0.366666666666667 1.1 1 1 abnormal cellular respiration 0.2740756557414 0.496698746879043 0.851032794909447 0.366666666666667 1.1 1 1 short ulna 0.228472407020418 0.473209918787085 0.849145804233373 0.365853658536585 1.1 1 1 abnormal basisphenoid bone morphology 0.332947082371852 0.545123720251024 0.843999466025898 0.363636363636364 1.1 1 1 abnormal skeleton physiology 0.271244347891053 0.496698746879043 0.843999466025898 0.363636363636364 1.1 1 1 abnormal innervation 0.224828129735995 0.467608672841378 0.839510107164058 0.361702127659574 1.1 1 1 short radius 0.268278491506395 0.496698746879043 0.83813835862294 0.361111111111111 1.1 1 1 abnormal stomach mucosa morphology 0.327502481613956 0.539690243799083 0.835559471365639 0.36 1.1 1 1 increased sacral vertebrae number 0.188153925851969 0.441748834881333 0.834108847283407 0.359375 1.1 1 1 abnormal action potential 0.185096782490625 0.434776436681236 0.828928046989721 0.357142857142857 1.1 1 1 abnormal somite shape 0.322157863892382 0.531058771658251 0.828928046989721 0.357142857142857 1.1 1 1 abnormal vasoconstriction 0.419441349691916 0.637555977609924 0.828928046989721 0.357142857142857 1.1 1 1 absent atrioventricular cushions 0.419441349691916 0.637555977609924 0.828928046989721 0.357142857142857 1.1 1 1 abnormal olfactory system physiology 0.419441349691916 0.637555977609924 0.828928046989721 0.357142857142857 1.1 1 1 abnormal ventral body wall morphology 0.419441349691916 0.637555977609924 0.828928046989721 0.357142857142857 1.1 1 1 abnormal vascular endothelial cell migration 0.419441349691916 0.637555977609924 0.828928046989721 0.357142857142857 1.1 1 1 abnormal sagittal suture morphology 0.419441349691916 0.637555977609924 0.828928046989721 0.357142857142857 1.1 1 1 abnormal squamosal bone morphology 0.419441349691916 0.637555977609924 0.828928046989721 0.357142857142857 1.1 1 1 abnormal positive T cell selection 0.419441349691916 0.637555977609924 0.828928046989721 0.357142857142857 1.1 1 1 increased B-1 B cell number 0.419441349691916 0.637555977609924 0.828928046989721 0.357142857142857 1.1 1 1 increased circulating growth hormone level 0.419441349691916 0.637555977609924 0.828928046989721 0.357142857142857 1.1 1 1 increased susceptibility to parasitic infection 0.155691876315492 0.388448889001793 0.825243922336433 0.355555555555556 1.1 1 1 abnormal cartilage development 0.25901158646038 0.496698746879043 0.825243922336433 0.355555555555556 1.1 1 1 abnormal hair shaft morphology 0.255887382377757 0.496698746879043 0.822020313264807 0.354166666666667 1.1 1 1 enlarged sebaceous gland 0.407149171828194 0.620958654152442 0.819175952319254 0.352941176470588 1.1 1 1 abnormal touch/ nociception 0.407149171828194 0.620958654152442 0.819175952319254 0.352941176470588 1.1 1 1 absence seizures 0.407149171828194 0.620958654152442 0.819175952319254 0.352941176470588 1.1 1 1 abnormal circulating chemokine level 0.407149171828194 0.620958654152442 0.819175952319254 0.352941176470588 1.1 1 1 abnormal survival 0.407149171828194 0.620958654152442 0.819175952319254 0.352941176470588 1.1 1 1 increased trabecular bone mass 0.407149171828194 0.620958654152442 0.819175952319254 0.352941176470588 1.1 1 1 decreased body fat mass 0.407149171828194 0.620958654152442 0.819175952319254 0.352941176470588 1.1 1 1 waved hair 0.396248417245365 0.606005495172361 0.812349486049927 0.35 1.1 1 1 nuclear cataracts 0.396248417245365 0.606005495172361 0.812349486049927 0.35 1.1 1 1 abnormal hair growth 0.284147036577324 0.496698746879043 0.803422568620806 0.346153846153846 1.1 1 1 abnormal nerve conduction 0.377354472578451 0.577642615716244 0.803422568620806 0.346153846153846 1.1 1 1 lordosis 0.368981585241504 0.564999503409197 0.800344321231455 0.344827586206897 1.1 1 1 absent long term depression 0.368981585241504 0.564999503409197 0.800344321231455 0.344827586206897 1.1 1 1 enlarged epididymis 0.368981585241504 0.564999503409197 0.800344321231455 0.344827586206897 1.1 1 1 increased dopamine level 0.36116146933637 0.553536139848565 0.797843245227607 0.34375 1.1 1 1 abnormal serotonin level 0.36116146933637 0.553536139848565 0.797843245227607 0.34375 1.1 1 1 short humerus 0.340272565731332 0.545123720251024 0.792536083951148 0.341463414634146 1.1 1 1 abnormal pancreatic islet morphology 0.316728054202122 0.522281097002174 0.788263652231735 0.339622641509434 1.1 1 1 trunk curl 0.453967344581622 0.67761402319039 0.773666177190406 0.333333333333333 1.1 1 1 increased vasoconstriction 0.453967344581622 0.67761402319039 0.773666177190406 0.333333333333333 1.1 1 1 decreased cochlear outer hair cell number 0.453967344581622 0.67761402319039 0.773666177190406 0.333333333333333 1.1 1 1 increased acute inflammation 0.453967344581622 0.67761402319039 0.773666177190406 0.333333333333333 1.1 1 1 abnormal clavicle morphology 0.453967344581622 0.67761402319039 0.773666177190406 0.333333333333333 1.1 1 1 abnormal reflex 0.396576620040386 0.606321046312514 0.773666177190406 0.333333333333333 1.1 1 1 decreased sensitivity to xenobiotic induced morbidity/mortality 0.406120030059028 0.620721090489606 0.773666177190406 0.333333333333333 1.1 1 1 abnormal estrous cycle 0.416434549991556 0.63492549378118 0.773666177190406 0.333333333333333 1.1 1 1 abnormal single cell response 0.427682626350554 0.649884259649971 0.773666177190406 0.333333333333333 1.1 1 1 abnormal digestive system morphology 0.440087393572384 0.665481696967359 0.773666177190406 0.333333333333333 1.1 1 1 abnormal osteoblast morphology 0.440087393572384 0.665481696967359 0.773666177190406 0.333333333333333 1.1 1 1 decreased chondrocyte number 0.488345797655711 0.684701499840551 0.773666177190406 0.333333333333333 1.1 1 1 cortical renal glomerulopathies 0.469799654368874 0.684701499840551 0.773666177190406 0.333333333333333 1.1 1 1 decreased salivation 0.488345797655711 0.684701499840551 0.773666177190406 0.333333333333333 1.1 1 1 hyperpigmentation 0.488345797655711 0.684701499840551 0.773666177190406 0.333333333333333 1.1 1 1 altered righting response 0.488345797655711 0.684701499840551 0.773666177190406 0.333333333333333 1.1 1 1 joint inflammation 0.488345797655711 0.684701499840551 0.773666177190406 0.333333333333333 1.1 1 1 decreased aggression towards males 0.488345797655711 0.684701499840551 0.773666177190406 0.333333333333333 1.1 1 1 increased susceptibility to autoimmune disorder 0.469799654368874 0.684701499840551 0.773666177190406 0.333333333333333 1.1 1 1 abnormal microglial cell activation 0.488345797655711 0.684701499840551 0.773666177190406 0.333333333333333 1.1 1 1 increased percent body fat/body weight 0.392362787605681 0.600432134216629 0.758787981475206 0.326923076923077 1.1 1 1 increased insulin secretion 0.439618279733412 0.665176685423882 0.752756280509584 0.324324324324324 1.1 1 1 abnormal respiratory electron transport chain 0.439618279733412 0.665176685423882 0.752756280509584 0.324324324324324 1.1 1 1 abnormal bone remodeling 0.451204210569491 0.674501486653611 0.750911289625983 0.323529411764706 1.1 1 1 abnormal eyelid morphology 0.463813912624806 0.684701499840551 0.748709203732651 0.32258064516129 1.1 1 1 abnormal stria vascularis morphology 0.47766804014653 0.684701499840551 0.746035242290749 0.321428571428571 1.1 1 1 parakeratosis 0.510443466946181 0.684701499840551 0.738499532772661 0.318181818181818 1.1 1 1 abnormal retinal layer morphology 0.510443466946181 0.684701499840551 0.738499532772661 0.318181818181818 1.1 1 1 increased susceptibility to ischemic brain injury 0.530427255396596 0.709375160107006 0.732946904706701 0.315789473684211 1.1 1 1 increased lung adenocarcinoma incidence 0.474483008154019 0.684701499840551 0.728156402061559 0.313725490196078 1.1 1 1 reduced male mating frequency 0.554014868308474 0.734797112725848 0.725312041116006 0.3125 1.1 1 1 white spotting 0.554014868308474 0.734797112725848 0.725312041116006 0.3125 1.1 1 1 increased pancreatic beta cell number 0.554014868308474 0.734797112725848 0.725312041116006 0.3125 1.1 1 1 bowed tibia 0.554014868308474 0.734797112725848 0.725312041116006 0.3125 1.1 1 1 abnormal wound healing 0.554014868308474 0.734797112725848 0.725312041116006 0.3125 1.1 1 1 decreased circulating growth hormone level 0.554014868308474 0.734797112725848 0.725312041116006 0.3125 1.1 1 1 decreased circulating prolactin level 0.554014868308474 0.734797112725848 0.725312041116006 0.3125 1.1 1 1 abnormal fertilization 0.554014868308474 0.734797112725848 0.725312041116006 0.3125 1.1 1 1 focal hair loss 0.526576944853791 0.704415246208016 0.720309889108309 0.310344827586207 1.1 1 1 abnormal lens fiber morphology 0.524536757832966 0.701874763372513 0.714153394329606 0.307692307692308 1.1 1 1 abnormal retinal cone cell morphology 0.564716067664297 0.748192393243642 0.706390857434719 0.304347826086957 1.1 1 1 abnormal sacral vertebrae morphology 0.564716067664297 0.748192393243642 0.706390857434719 0.304347826086957 1.1 1 1 abnormal regulatory T cell physiology 0.564716067664297 0.748192393243642 0.706390857434719 0.304347826086957 1.1 1 1 belly spot 0.555845455015428 0.737028555091086 0.703332888354915 0.303030303030303 1.1 1 1 hypoalgesia 0.641518522613324 0.820219167329452 0.663142437591777 0.285714285714286 1.1 1 1 decreased pancreatic beta cell number 0.737055464258765 0.909090564485234 0.61438196423944 0.264705882352941 1.1 1 1 eyelids fail to open 0.721388505187451 0.890990023164739 0.610789087255584 0.263157894736842 1.1 1 1 decreased liver glycogen level 0.721388505187451 0.890990023164739 0.610789087255584 0.263157894736842 1.1 1 1 cryptorchism 0.747777806861124 0.909090564485234 0.601740360036983 0.259259259259259 1.1 1 1 abnormal basioccipital bone morphology 0.76587384966756 0.914160845032656 0.580249632892805 0.25 1.1 1 1 abnormal eye physiology 0.903426612542897 1 0.541566324033284 0.233333333333333 1.1 1 1 abnormal body temperature homeostasis 0.939008159979998 1 0.449225522239591 0.193548387096774 1.1 1 1 abnormal blood pressure regulation 1.69325858886215e-05 0.000946512525796538 7.99602227525855 1 1.3 1 3 delayed limb development 9.21954565952468e-05 0.00375960980787994 6.66335189604879 0.833333333333333 1.3 1 3 abnormal vascular endothelial cell development 4.12486253157517e-07 4.18799818256867e-05 5.99701670644391 0.75 1.3 1 3 arteritis 0.000292914196869981 0.00971498752952105 5.71144448232754 0.714285714285714 1.3 1 3 abnormal artery development 0.000117077837610907 0.00448047878549431 5.33068151683903 0.666666666666667 1.3 1 3 abnormal umbilical artery morphology 0.000709255020706258 0.0177313755176564 4.9975139220366 0.625 1.3 1 3 increased cardiac output 0.000709255020706258 0.0177313755176564 4.9975139220366 0.625 1.3 1 3 elevated level of mitotic sister chromatid exchange 0.000709255020706258 0.0177313755176564 4.9975139220366 0.625 1.3 1 3 abnormal olfactory bulb mitral cell layer morphology 0.000709255020706258 0.0177313755176564 4.9975139220366 0.625 1.3 1 3 abnormal hepatic vein morphology 0.000709255020706258 0.0177313755176564 4.9975139220366 0.625 1.3 1 3 abnormal bronchiole epithelium morphology 0.000709255020706258 0.0177313755176564 4.9975139220366 0.625 1.3 1 3 increased atrioventricular cushion size 0.000265030465090148 0.00884917156928513 4.79761336515513 0.6 1.3 1 3 increased circulating fructosamine level 0.000265030465090148 0.00884917156928513 4.79761336515513 0.6 1.3 1 3 decreased circulating lactate level 0.000265030465090148 0.00884917156928513 4.79761336515513 0.6 1.3 1 3 abnormal germ cell morphology 0.00144947649957544 0.0276289102888423 4.44223459736586 0.555555555555556 1.3 1 3 increased neuronal precursor cell number 0.00144947649957544 0.0276289102888423 4.44223459736586 0.555555555555556 1.3 1 3 iris coloboma 0.00144947649957544 0.0276289102888423 4.44223459736586 0.555555555555556 1.3 1 3 abnormal ductus venosus valve topology 0.00144947649957544 0.0276289102888423 4.44223459736586 0.555555555555556 1.3 1 3 abnormal vascular regression 2.0300210076953e-06 0.000157802414270065 4.3978122513922 0.55 1.3 1 3 abnormal vascular branching morphogenesis 7.72724619441808e-07 7.11908329948703e-05 4.36146669559557 0.545454545454545 1.3 1 3 liver vascular congestion 7.22770464313085e-05 0.00309981298272207 4.26454521347123 0.533333333333333 1.3 1 3 abnormal lymphatic vessel morphology 5.48797482763577e-08 7.00068583781743e-06 3.99801113762928 0.5 1.3 1 3 dilated vasculature 1.82827326853535e-05 0.000999523023182785 3.99801113762928 0.5 1.3 1 3 fused cornea and lens 0.00263392253406075 0.0413367968673572 3.99801113762928 0.5 1.3 1 3 bifid ureter 0.00263392253406075 0.0413367968673572 3.99801113762928 0.5 1.3 1 3 abnormal developmental vascular remodeling 0.00263392253406075 0.0413367968673572 3.99801113762928 0.5 1.3 1 3 abnormal blood flow velocity 0.00035172606904176 0.0108934676806607 3.99801113762928 0.5 1.3 1 3 decreased circulating fructosamine level 1.7142710778945e-06 0.000139811452664346 3.84993665105041 0.481481481481481 1.3 1 3 delayed intramembranous bone ossification 0.000596243963825903 0.0158536812399085 3.73147706178732 0.466666666666667 1.3 1 3 abnormal pericyte morphology 0.000596243963825903 0.0158536812399085 3.73147706178732 0.466666666666667 1.3 1 3 absent hypoglossal nerve 0.00161017445638842 0.0297792487752134 3.6904718193501 0.461538461538462 1.3 1 3 enlarged pericardium 6.93030709454965e-07 6.63043803757395e-05 3.63455557966298 0.454545454545455 1.3 1 3 pulmonary vascular congestion 5.18570070809982e-05 0.00230346973417827 3.63455557966298 0.454545454545455 1.3 1 3 abnormal sebaceous gland morphology 0.00438878675177137 0.0593321035056049 3.63455557966298 0.454545454545455 1.3 1 3 palatal shelf hypoplasia 0.00438878675177137 0.0593321035056049 3.63455557966298 0.454545454545455 1.3 1 3 chylous ascites 0.00438878675177137 0.0593321035056049 3.63455557966298 0.454545454545455 1.3 1 3 thin hypoglossal nerve 0.00438878675177137 0.0593321035056049 3.63455557966298 0.454545454545455 1.3 1 3 abnormal capillary morphology 1.79963538511051e-06 0.000142114064141664 3.61110683398773 0.451612903225806 1.3 1 3 absent ductus venosus valve 0.000136668863877574 0.00511223757737541 3.59821002386635 0.45 1.3 1 3 abnormal mammary gland morphology 0.00036129088790131 0.0108934676806607 3.55378767789269 0.444444444444444 1.3 1 3 thick dermal layer 0.00036129088790131 0.0108934676806607 3.55378767789269 0.444444444444444 1.3 1 3 increased circulating renin level 0.00036129088790131 0.0108934676806607 3.55378767789269 0.444444444444444 1.3 1 3 abnormal pregnancy 0.00036129088790131 0.0108934676806607 3.55378767789269 0.444444444444444 1.3 1 3 liver hypoplasia 1.48617033901558e-09 3.08070726525105e-07 3.53670216021051 0.442307692307692 1.3 1 3 abnormal embryonic hematopoiesis 2.87157564083582e-06 0.000207999257953207 3.49825974542562 0.4375 1.3 1 3 vasculature congestion 0.000958536764078936 0.0219756700520401 3.49825974542562 0.4375 1.3 1 3 small pancreas 0.000958536764078936 0.0219756700520401 3.49825974542562 0.4375 1.3 1 3 abnormal artery morphology 1.74652574460757e-06 0.000140144606119721 3.42686668939652 0.428571428571429 1.3 1 3 abnormal fluid regulation 0.00255401074689843 0.0409877531155474 3.42686668939652 0.428571428571429 1.3 1 3 incomplete somite formation 1.05478612071864e-06 9.04751888030216e-05 3.3667462211615 0.421052631578947 1.3 1 3 right-sided stomach 0.000563396911945118 0.0151797119844775 3.3667462211615 0.421052631578947 1.3 1 3 mesocardia 0.00684019732455864 0.0810237659278077 3.3316759480244 0.416666666666667 1.3 1 3 impaired embryo implantation 0.00684019732455864 0.0810237659278077 3.3316759480244 0.416666666666667 1.3 1 3 interstitial pneumonia 0.00684019732455864 0.0810237659278077 3.3316759480244 0.416666666666667 1.3 1 3 dilated bile duct 0.00684019732455864 0.0810237659278077 3.3316759480244 0.416666666666667 1.3 1 3 delayed somite formation 0.00684019732455864 0.0810237659278077 3.3316759480244 0.416666666666667 1.3 1 3 abnormal patella morphology 0.00684019732455864 0.0810237659278077 3.3316759480244 0.416666666666667 1.3 1 3 abnormal aorta elastic tissue morphology 0.00684019732455864 0.0810237659278077 3.3316759480244 0.416666666666667 1.3 1 3 abnormal adipose tissue morphology 0.0014738584189487 0.027986433718587 3.29247976040058 0.411764705882353 1.3 1 3 pale yolk sac 2.75637443086033e-12 9.14197519568677e-10 3.27547900432278 0.409638554216867 1.3 1 3 abnormal germ layer development 0.000328971257017055 0.0106969412003912 3.27110002169668 0.409090909090909 1.3 1 3 abnormal cricoid cartilage morphology 0.0038591886022801 0.0554897783131316 3.19840891010342 0.4 1.3 1 3 heterochrony 0.0038591886022801 0.0554897783131316 3.19840891010342 0.4 1.3 1 3 abnormal liver development 1.02220727066378e-05 0.0006054144251848 3.19840891010342 0.4 1.3 1 3 trabecula carnea hypoplasia 5.65957584915933e-07 5.63127796991354e-05 3.19840891010342 0.4 1.3 1 3 abnormal vascular development 2.70474345868321e-09 4.98374026183296e-07 3.14994816904125 0.393939393939394 1.3 1 3 premature aging 0.00011116261537153 0.00432057821463563 3.14129446528015 0.392857142857143 1.3 1 3 hypoxia 0.00011116261537153 0.00432057821463563 3.14129446528015 0.392857142857143 1.3 1 3 abnormal cell differentiation 3.52613766093638e-06 0.000243646317543868 3.12039893668626 0.390243902439024 1.3 1 3 abnormal mitral valve morphology 0.00218185593870613 0.0364252795136342 3.1095642181561 0.388888888888889 1.3 1 3 absent spleen 0.00218185593870613 0.0364252795136342 3.1095642181561 0.388888888888889 1.3 1 3 increased gastrointestinal tumor incidence 0.00218185593870613 0.0364252795136342 3.1095642181561 0.388888888888889 1.3 1 3 excessive scratching 0.010108961617165 0.107946503509852 3.07539318279175 0.384615384615385 1.3 1 3 skin edema 5.10890810286074e-06 0.000334431813312265 3.04610372390802 0.380952380952381 1.3 1 3 left pulmonary isomerism 0.00123697516392952 0.0261870274065929 3.04610372390802 0.380952380952381 1.3 1 3 abnormal tumor vascularization 0.00123697516392952 0.0261870274065929 3.04610372390802 0.380952380952381 1.3 1 3 abnormal tumor morphology 0.000703243733597406 0.0177313755176564 2.99850835322196 0.375 1.3 1 3 delayed hair appearance 0.0055995797052008 0.0699947463150101 2.99850835322196 0.375 1.3 1 3 increased heart left ventricle size 0.0055995797052008 0.0699947463150101 2.99850835322196 0.375 1.3 1 3 abnormal pulmonary alveolus wall morphology 0.0055995797052008 0.0699947463150101 2.99850835322196 0.375 1.3 1 3 abnormal vitelline vasculature morphology 1.69567049935723e-13 7.02996727858518e-11 2.98981702466189 0.373913043478261 1.3 1 3 abnormal vasculogenesis 7.29813263851707e-06 0.000448249504649659 2.97526410242179 0.372093023255814 1.3 1 3 thick pulmonary interalveolar septum 5.34679062597672e-05 0.00235400737736586 2.96995113081032 0.371428571428571 1.3 1 3 short vibrissae 0.00312595703765005 0.0475105071738528 2.94590294351631 0.368421052631579 1.3 1 3 abnormal brain vasculature morphology 0.000229009495745506 0.00804480569389157 2.93187483426147 0.366666666666667 1.3 1 3 liver fibrosis 1.78043620708734e-05 0.000984185570028837 2.92537400314337 0.365853658536585 1.3 1 3 subcutaneous edema 0.000561775456805591 0.0151797119844775 2.85572224116377 0.357142857142857 1.3 1 3 midline facial cleft 0.0143061565450909 0.124748197837098 2.85572224116377 0.357142857142857 1.3 1 3 abnormal adrenal gland secretion 0.0143061565450909 0.124748197837098 2.85572224116377 0.357142857142857 1.3 1 3 abnormal endplate potential 0.0143061565450909 0.124748197837098 2.85572224116377 0.357142857142857 1.3 1 3 decreased vascular permeability 0.0143061565450909 0.124748197837098 2.85572224116377 0.357142857142857 1.3 1 3 amyloid beta deposits 0.0143061565450909 0.124748197837098 2.85572224116377 0.357142857142857 1.3 1 3 vascular smooth muscle hypoplasia 0.0143061565450909 0.124748197837098 2.85572224116377 0.357142857142857 1.3 1 3 abnormal maternal decidual layer morphology 0.0143061565450909 0.124748197837098 2.85572224116377 0.357142857142857 1.3 1 3 abnormal viscerocranium morphology 0.0143061565450909 0.124748197837098 2.85572224116377 0.357142857142857 1.3 1 3 increased pulmonary respiratory rate 0.0143061565450909 0.124748197837098 2.85572224116377 0.357142857142857 1.3 1 3 pulmonary alveolar hemorrhage 0.0143061565450909 0.124748197837098 2.85572224116377 0.357142857142857 1.3 1 3 abnormal vitelline vein topology 0.0143061565450909 0.124748197837098 2.85572224116377 0.357142857142857 1.3 1 3 pericardial edema 1.31003795428035e-07 1.5142403254946e-05 2.82212550891478 0.352941176470588 1.3 1 3 abnormal interatrial septum morphology 0.00784997313406559 0.0875641622017407 2.82212550891478 0.352941176470588 1.3 1 3 increased cell proliferation 2.75626162509832e-06 0.000204662710221853 2.81341524499838 0.351851851851852 1.3 1 3 abnormal angiogenesis 4.42342540396007e-08 6.11292816241704e-06 2.8094132318476 0.351351351351351 1.3 1 3 abnormal circulating enzyme level 0.0043526126778259 0.0593321035056049 2.79860779634049 0.35 1.3 1 3 abnormal dopamine level 0.0043526126778259 0.0593321035056049 2.79860779634049 0.35 1.3 1 3 abnormal heart right ventricle morphology 0.0043526126778259 0.0593321035056049 2.79860779634049 0.35 1.3 1 3 abnormal induced retinal neovascularization 0.0043526126778259 0.0593321035056049 2.79860779634049 0.35 1.3 1 3 abnormal Mullerian duct morphology 0.00136755348912616 0.0269906800615733 2.76785386451258 0.346153846153846 1.3 1 3 blood in lymph vessels 0.000772625021054989 0.018750290145115 2.75724906043398 0.344827586206897 1.3 1 3 abnormal vertebral body morphology 0.00043824309450288 0.0127500549424083 2.74863265712013 0.34375 1.3 1 3 abnormal heart atrium morphology 0.00043824309450288 0.0127500549424083 2.74863265712013 0.34375 1.3 1 3 hemopericardium 8.14130431695888e-05 0.00337524908140587 2.73034906960048 0.341463414634146 1.3 1 3 intracranial hemorrhage 3.96974675269202e-06 0.000270540960200586 2.66534075841952 0.333333333333333 1.3 1 3 incomplete embryo turning 6.87935698158872e-06 0.000433225328903847 2.66534075841952 0.333333333333333 1.3 1 3 abnormal cell adhesion 1.19349670793536e-05 0.000698546602585698 2.66534075841952 0.333333333333333 1.3 1 3 abnormal pharyngeal arch morphology 0.000336496581226238 0.0107123648450191 2.66534075841952 0.333333333333333 1.3 1 3 abnormal retinal blood vessel morphology 0.000336496581226238 0.0107123648450191 2.66534075841952 0.333333333333333 1.3 1 3 abnormal cellular respiration 0.00104443278370973 0.022890101757515 2.66534075841952 0.333333333333333 1.3 1 3 abnormal brain commissure morphology 0.00185090908411396 0.033242861709267 2.66534075841952 0.333333333333333 1.3 1 3 vascular ring 0.00591043143477409 0.0726034478716076 2.66534075841952 0.333333333333333 1.3 1 3 lowered ear position 0.0106840317317454 0.111198865827266 2.66534075841952 0.333333333333333 1.3 1 3 eye inflammation 0.0106840317317454 0.111198865827266 2.66534075841952 0.333333333333333 1.3 1 3 absent inner cell mass 0.0106840317317454 0.111198865827266 2.66534075841952 0.333333333333333 1.3 1 3 darkened coat color 0.0106840317317454 0.111198865827266 2.66534075841952 0.333333333333333 1.3 1 3 jerky movement 0.0106840317317454 0.111198865827266 2.66534075841952 0.333333333333333 1.3 1 3 abnormal enteric neuron morphology 0.0195296405164963 0.155978669900868 2.66534075841952 0.333333333333333 1.3 1 3 abnormal pup retrieval 0.0195296405164963 0.155978669900868 2.66534075841952 0.333333333333333 1.3 1 3 placental labyrinth hypoplasia 0.0195296405164963 0.155978669900868 2.66534075841952 0.333333333333333 1.3 1 3 abnormal olfactory nerve morphology 0.0195296405164963 0.155978669900868 2.66534075841952 0.333333333333333 1.3 1 3 abnormal energy homeostasis 0.0195296405164963 0.155978669900868 2.66534075841952 0.333333333333333 1.3 1 3 abnormal coronary vessel morphology 0.0195296405164963 0.155978669900868 2.66534075841952 0.333333333333333 1.3 1 3 decreased circulating serum albumin level 3.32985223590908e-09 5.71241892194747e-07 2.66534075841952 0.333333333333333 1.3 1 3 failure of heart looping 0.000191884112828017 0.00686779468575097 2.66534075841952 0.333333333333333 1.3 1 3 enlarged liver sinusoidal spaces 0.000787699322473326 0.0190233210160427 2.58694838317188 0.323529411764706 1.3 1 3 abnormal object recognition memory 0.0013896427792452 0.0270487357011144 2.57936202427695 0.32258064516129 1.3 1 3 pale kidney 0.0013896427792452 0.0270487357011144 2.57936202427695 0.32258064516129 1.3 1 3 lymphoid hyperplasia 0.00246155132862844 0.039760447597164 2.57015001704739 0.321428571428571 1.3 1 3 absent corpus callosum 0.00246155132862844 0.039760447597164 2.57015001704739 0.321428571428571 1.3 1 3 small liver 5.98813655691983e-07 5.84136850405415e-05 2.56282765232646 0.320512820512821 1.3 1 3 spontaneous skin ulceration 0.0043819873825023 0.0593321035056049 2.55872712808274 0.32 1.3 1 3 abnormal tail movements 0.00784924331932488 0.0875641622017407 2.54418890576408 0.318181818181818 1.3 1 3 abnormal basement membrane morphology 0.00784924331932488 0.0875641622017407 2.54418890576408 0.318181818181818 1.3 1 3 abnormal blood-brain barrier function 0.00784924331932488 0.0875641622017407 2.54418890576408 0.318181818181818 1.3 1 3 increased circulating creatine kinase level 0.00784924331932488 0.0875641622017407 2.54418890576408 0.318181818181818 1.3 1 3 abnormal blood vessel morphology 2.07162314545167e-11 6.0625442050718e-09 2.53666913559926 0.317241379310345 1.3 1 3 lethality throughout fetal growth and development, complete penetrance 2.48284747481348e-14 1.23521661871971e-11 2.52505966587112 0.315789473684211 1.3 1 3 absent vitelline blood vessels 2.75399042465043e-05 0.00139807166965672 2.52505966587112 0.315789473684211 1.3 1 3 abnormal stationary movement 0.0141723738982509 0.124748197837098 2.52505966587112 0.315789473684211 1.3 1 3 maternal imprinting 0.0141723738982509 0.124748197837098 2.52505966587112 0.315789473684211 1.3 1 3 oliguria 0.0141723738982509 0.124748197837098 2.52505966587112 0.315789473684211 1.3 1 3 decreased liver glycogen level 0.0141723738982509 0.124748197837098 2.52505966587112 0.315789473684211 1.3 1 3 thin interventricular septum 0.0141723738982509 0.124748197837098 2.52505966587112 0.315789473684211 1.3 1 3 embryonic lethality between implantation and somite formation, incomplete penetrance 0.0141723738982509 0.124748197837098 2.52505966587112 0.315789473684211 1.3 1 3 abnormal apoptosis 4.77586024015648e-05 0.00215999133588896 2.51726627184066 0.314814814814815 1.3 1 3 scoliosis 0.0018220971814008 0.0328439618748876 2.4987569610183 0.3125 1.3 1 3 abnormal spongiotrophoblast layer morphology 0.0018220971814008 0.0328439618748876 2.4987569610183 0.3125 1.3 1 3 abnormal hair follicle orientation 0.0258614863398124 0.188929360558835 2.4987569610183 0.3125 1.3 1 3 disorganized yolk sac vascular plexus 0.0258614863398124 0.188929360558835 2.4987569610183 0.3125 1.3 1 3 blepharitis 0.0258614863398124 0.188929360558835 2.4987569610183 0.3125 1.3 1 3 embryonic lethality between somite formation and embryo turning, incomplete penetrance 0.0258614863398124 0.188929360558835 2.4987569610183 0.3125 1.3 1 3 thin ventricular wall 2.60377038820884e-07 2.75611865560404e-05 2.48765137452488 0.311111111111111 1.3 1 3 abnormal cell migration 0.000251068645124223 0.00861455206628896 2.48765137452488 0.311111111111111 1.3 1 3 abnormal spinal nerve morphology 0.00322156816703651 0.0480215776484043 2.48152415439059 0.310344827586207 1.3 1 3 increased mortality induced by gamma-irradiation 0.00322156816703651 0.0480215776484043 2.48152415439059 0.310344827586207 1.3 1 3 abnormal embryonic erythropoiesis 0.00322156816703651 0.0480215776484043 2.48152415439059 0.310344827586207 1.3 1 3 decreased circulating total protein level 6.20086748326738e-05 0.00268254919384828 2.47149779417083 0.309090909090909 1.3 1 3 ventricular septal defect 3.88329797451136e-10 8.78154882872456e-08 2.46935982030044 0.308823529411765 1.3 1 3 increased vascular permeability 0.000765626574239814 0.0186715304257013 2.4603145462334 0.307692307692308 1.3 1 3 increased hepatocyte apoptosis 0.000765626574239814 0.0186715304257013 2.4603145462334 0.307692307692308 1.3 1 3 abnormal stomach morphology 0.00572173577955835 0.0709866222027501 2.4603145462334 0.307692307692308 1.3 1 3 thick skin 0.00572173577955835 0.0709866222027501 2.4603145462334 0.307692307692308 1.3 1 3 abnormal ocular fundus morphology 0.00572173577955835 0.0709866222027501 2.4603145462334 0.307692307692308 1.3 1 3 hemorrhage 4.06326646820573e-16 2.88782152561764e-13 2.44984512263241 0.306382978723404 1.3 1 3 impaired wound healing 0.00134150744248058 0.0269906800615733 2.44322902855122 0.305555555555556 1.3 1 3 decreased effector memory CD8-positive, alpha-beta T cell number 0.0102191294556241 0.108632839832756 2.43357199681782 0.304347826086957 1.3 1 3 abnormal aorta morphology 0.00235700483553902 0.0386999968871506 2.42303705310865 0.303030303030303 1.3 1 3 dilated heart atrium 0.00235700483553902 0.0386999968871506 2.42303705310865 0.303030303030303 1.3 1 3 kidney failure 0.000564471701935345 0.0151797119844775 2.4174020832177 0.302325581395349 1.3 1 3 atrioventricular septal defect 0.000138209350654181 0.0051312799963026 2.41389351705919 0.30188679245283 1.3 1 3 decreased embryo size 5.72152563966077e-30 1.42322950286562e-26 2.40884353062182 0.301255230125523 1.3 1 3 perinatal lethality, incomplete penetrance 7.19113338668787e-15 3.97509873319691e-12 2.40588280848487 0.300884955752212 1.3 1 3 embryonic lethality during organogenesis, complete penetrance 1.57690296070664e-34 7.84509222951553e-31 2.39880668257757 0.3 1.3 1 3 embryonic lethality between somite formation and embryo turning, complete penetrance 1.48058288872031e-05 0.000837034076293582 2.39880668257757 0.3 1.3 1 3 delayed eyelid opening 0.00415462618846228 0.0580597339539321 2.39880668257757 0.3 1.3 1 3 abnormal lactation 0.00415462618846228 0.0580597339539321 2.39880668257757 0.3 1.3 1 3 abnormal basioccipital bone morphology 0.0183808429927187 0.149111062929718 2.39880668257757 0.3 1.3 1 3 abnormal trachea morphology 0.0183808429927187 0.149111062929718 2.39880668257757 0.3 1.3 1 3 kidney atrophy 0.0183808429927187 0.149111062929718 2.39880668257757 0.3 1.3 1 3 abnormal neuron proliferation 0.0183808429927187 0.149111062929718 2.39880668257757 0.3 1.3 1 3 double outlet right ventricle 1.0542061760098e-07 1.27918920137775e-05 2.39133376456331 0.299065420560748 1.3 1 3 internal hemorrhage 2.5453448912392e-05 0.00130547328184691 2.3868723209727 0.298507462686567 1.3 1 3 abnormal cell morphology 4.6070751311753e-08 6.1946483182695e-06 2.38477857332273 0.298245614035088 1.3 1 3 abnormal axon morphology 1.33922762455804e-07 1.5142403254946e-05 2.36919178526179 0.296296296296296 1.3 1 3 abnormal atrioventricular cushion morphology 0.00735155754606126 0.084332572838004 2.36919178526179 0.296296296296296 1.3 1 3 corneal opacity 1.88355116606414e-05 0.00101855076643143 2.3650206729638 0.295774647887324 1.3 1 3 lethality, incomplete penetrance 0.000720456417462364 0.0178362275017734 2.36246112678094 0.295454545454545 1.3 1 3 abnormal extraembryonic tissue morphology 3.8905500094006e-07 4.03239297849333e-05 2.35177125742899 0.294117647058824 1.3 1 3 overexpanded pulmonary alveoli 0.00301088213264973 0.0463750421360136 2.35177125742899 0.294117647058824 1.3 1 3 increased incidence of corneal inflammation 0.0333662835088736 0.218035104423838 2.35177125742899 0.294117647058824 1.3 1 3 common atrium 0.0333662835088736 0.218035104423838 2.35177125742899 0.294117647058824 1.3 1 3 delayed heart development 0.0333662835088736 0.218035104423838 2.35177125742899 0.294117647058824 1.3 1 3 scaly skin 0.00125232123214034 0.0262441879627655 2.3402992025147 0.292682926829268 1.3 1 3 increased bone trabecula number 0.00125232123214034 0.0262441879627655 2.3402992025147 0.292682926829268 1.3 1 3 small heart 0.000526558965423603 0.0147009626754362 2.33217316361708 0.291666666666667 1.3 1 3 abnormal lymph node morphology 0.000526558965423603 0.0147009626754362 2.33217316361708 0.291666666666667 1.3 1 3 vertebral transformation 0.000526558965423603 0.0147009626754362 2.33217316361708 0.291666666666667 1.3 1 3 decreased body height 0.0130694513188728 0.119085202035517 2.33217316361708 0.291666666666667 1.3 1 3 abnormal body weight 0.0130694513188728 0.119085202035517 2.33217316361708 0.291666666666667 1.3 1 3 ocular hypertelorism 0.0130694513188728 0.119085202035517 2.33217316361708 0.291666666666667 1.3 1 3 abnormal vasodilation 0.0130694513188728 0.119085202035517 2.33217316361708 0.291666666666667 1.3 1 3 abnormal inner cell mass apoptosis 0.0130694513188728 0.119085202035517 2.33217316361708 0.291666666666667 1.3 1 3 pericardial effusion 9.51755753958909e-05 0.00384958119995575 2.32142582184926 0.290322580645161 1.3 1 3 abnormal eyelid morphology 0.00528575576496017 0.0669127545739668 2.32142582184926 0.290322580645161 1.3 1 3 microcephaly 4.07838310603351e-05 0.00191414678797327 2.31768761601697 0.289855072463768 1.3 1 3 albuminuria 0.000911145199974733 0.0210834761389502 2.30996199063025 0.288888888888889 1.3 1 3 small placenta 0.000911145199974733 0.0210834761389502 2.30996199063025 0.288888888888889 1.3 1 3 distended pericardium 0.000384449412869256 0.0113847370775271 2.30654488709381 0.288461538461538 1.3 1 3 abnormal eye morphology 9.72515776731351e-09 1.56073096427047e-06 2.30101360439095 0.287769784172662 1.3 1 3 abnormal cell cycle 1.98237144707343e-07 2.14397781504137e-05 2.2945107398568 0.28695652173913 1.3 1 3 disheveled coat 0.0015780543751469 0.0294393115206974 2.28457779293102 0.285714285714286 1.3 1 3 abnormal cytotoxic T cell physiology 0.0015780543751469 0.0294393115206974 2.28457779293102 0.285714285714286 1.3 1 3 abnormal eye pigmentation 0.0233690076158965 0.175886252479705 2.28457779293102 0.285714285714286 1.3 1 3 trunk curl 0.0233690076158965 0.175886252479705 2.28457779293102 0.285714285714286 1.3 1 3 complete atrioventricular septal defect 0.0233690076158965 0.175886252479705 2.28457779293102 0.285714285714286 1.3 1 3 absent segment of posterior cerebral artery 0.0233690076158965 0.175886252479705 2.28457779293102 0.285714285714286 1.3 1 3 abnormal embryonic tissue morphology 5.31659601415807e-09 8.81668839014546e-07 2.28457779293101 0.285714285714286 1.3 1 3 ovary cysts 0.00380146666953736 0.0551378911981002 2.28457779293101 0.285714285714286 1.3 1 3 rib bifurcation 0.00930756003303439 0.100444926603788 2.28457779293101 0.285714285714286 1.3 1 3 straub tail 0.00930756003303439 0.100444926603788 2.28457779293101 0.285714285714286 1.3 1 3 corneal vascularization 0.00930756003303439 0.100444926603788 2.28457779293101 0.285714285714286 1.3 1 3 abnormal renal tubule epithelium morphology 0.00930756003303439 0.100444926603788 2.28457779293101 0.285714285714286 1.3 1 3 lethality throughout fetal growth and development, incomplete penetrance 1.44263511152795e-10 3.77742614729029e-08 2.27819629071612 0.284916201117318 1.3 1 3 edema 3.29346009498808e-10 7.80236379645985e-08 2.27793657841668 0.284883720930233 1.3 1 3 abnormal heart development 1.71833189166719e-09 3.41948046441771e-07 2.27734811637111 0.284810126582278 1.3 1 3 kidney cysts 3.7488663823707e-05 0.0017762485954566 2.26914145649229 0.283783783783784 1.3 1 3 abnormal cell death 0.00114233172815611 0.0246021660068254 2.25974542561655 0.282608695652174 1.3 1 3 abnormal allantois morphology 0.00114233172815611 0.0246021660068254 2.25974542561655 0.282608695652174 1.3 1 3 increased fibroblast apoptosis 0.00664110042809209 0.07999872791709 2.24888126491647 0.28125 1.3 1 3 abnormal facial morphology 0.000350112951294919 0.0108934676806607 2.24449748077433 0.280701754385965 1.3 1 3 pallor 6.32262192573196e-10 1.36761061219637e-07 2.23888623707239 0.28 1.3 1 3 abnormal interventricular septum morphology 0.000827117456975721 0.0197832180214145 2.23888623707239 0.28 1.3 1 3 abnormal circulating protein level 0.000827117456975721 0.0197832180214145 2.23888623707239 0.28 1.3 1 3 abnormal keratinocyte physiology 0.0164479095163502 0.139638822259116 2.23888623707239 0.28 1.3 1 3 increased cellular sensitivity to ionizing radiation 0.0164479095163502 0.139638822259116 2.23888623707239 0.28 1.3 1 3 decreased placenta weight 0.0164479095163502 0.139638822259116 2.23888623707239 0.28 1.3 1 3 delayed endochondral bone ossification 0.00197040895832558 0.0334566026200333 2.23144807681634 0.27906976744186 1.3 1 3 abnormal placenta morphology 3.40807261040854e-05 0.00164613215891092 2.22674038045175 0.278481012658228 1.3 1 3 abnormal myocardium layer morphology 3.40807261040854e-05 0.00164613215891092 2.22674038045175 0.278481012658228 1.3 1 3 decreased tumor growth/size 0.000599093884040762 0.0158536812399085 2.22111729868293 0.277777777777778 1.3 1 3 abnormal bile duct morphology 0.0420902265000767 0.255676284295338 2.22111729868293 0.277777777777778 1.3 1 3 acidosis 0.0420902265000767 0.255676284295338 2.22111729868293 0.277777777777778 1.3 1 3 decreased tumor latency 0.0420902265000767 0.255676284295338 2.22111729868293 0.277777777777778 1.3 1 3 increased effector memory CD4-positive, alpha-beta T cell number 0.0420902265000767 0.255676284295338 2.22111729868293 0.277777777777778 1.3 1 3 increased effector memory CD8-positive, alpha-beta T cell number 0.0420902265000767 0.255676284295338 2.22111729868293 0.277777777777778 1.3 1 3 abnormal hypoglossal nerve topology 0.0420902265000767 0.255676284295338 2.22111729868293 0.277777777777778 1.3 1 3 hepatic necrosis 0.00142041741844087 0.0274964072246821 2.21166573570981 0.276595744680851 1.3 1 3 decreased trophoblast giant cell number 0.0116260331248431 0.114449888811311 2.20579924834719 0.275862068965517 1.3 1 3 increased susceptibility to induced arthritis 0.0116260331248431 0.114449888811311 2.20579924834719 0.275862068965517 1.3 1 3 increased lymphocyte cell number 0.00013454558623852 0.00507094160255028 2.20180323521612 0.27536231884058 1.3 1 3 distended abdomen 0.00102484196630916 0.0226603945883915 2.19498650693372 0.274509803921569 1.3 1 3 abnormal trophoblast layer morphology 0.00102484196630916 0.0226603945883915 2.19498650693372 0.274509803921569 1.3 1 3 failure of chorioallantoic fusion 0.00102484196630916 0.0226603945883915 2.19498650693372 0.274509803921569 1.3 1 3 hydronephrosis 3.0699538560446e-05 0.00151218024097246 2.18938705155889 0.273809523809524 1.3 1 3 alopecia 9.69504472964631e-06 0.000581118644939643 2.18838504375497 0.273684210526316 1.3 1 3 kyphosis 3.22216000205481e-08 4.58007028863506e-06 2.185579421904 0.273333333333333 1.3 1 3 abnormal rostral-caudal axis patterning 0.000740061548291045 0.0182267633799404 2.18073334779779 0.272727272727273 1.3 1 3 omphalocele 0.00243914116114927 0.0396559714925413 2.18073334779779 0.272727272727273 1.3 1 3 decreased blood urea nitrogen level 0.00243914116114927 0.0396559714925413 2.18073334779779 0.272727272727273 1.3 1 3 decreased sensitivity to induced morbidity/mortality 0.00243914116114927 0.0396559714925413 2.18073334779779 0.272727272727273 1.3 1 3 myeloid hyperplasia 0.00824763627529948 0.0913852794423495 2.18073334779779 0.272727272727273 1.3 1 3 increased skin papilloma incidence 0.0291889192271109 0.20395347353213 2.18073334779779 0.272727272727273 1.3 1 3 increased myocardial infarction size 0.0291889192271109 0.20395347353213 2.18073334779779 0.272727272727273 1.3 1 3 decreased cardiac output 0.0291889192271109 0.20395347353213 2.18073334779779 0.272727272727273 1.3 1 3 cleft upper lip 0.0291889192271109 0.20395347353213 2.18073334779779 0.272727272727273 1.3 1 3 decreased circulating estradiol level 0.0291889192271109 0.20395347353213 2.18073334779779 0.272727272727273 1.3 1 3 abnormal occipital bone morphology 0.0291889192271109 0.20395347353213 2.18073334779779 0.272727272727273 1.3 1 3 rough coat 0.0291889192271109 0.20395347353213 2.18073334779779 0.272727272727273 1.3 1 3 increased mammary gland tumor incidence 0.0291889192271109 0.20395347353213 2.18073334779779 0.272727272727273 1.3 1 3 syndactyly 0.000534849094322402 0.0147009626754362 2.1684128204091 0.271186440677966 1.3 1 3 curly tail 0.00175242198670441 0.0318186108899797 2.16558936621586 0.270833333333333 1.3 1 3 malocclusion 0.0058691150822334 0.0722743750844336 2.16108710142123 0.27027027027027 1.3 1 3 increased circulating phosphate level 0.0058691150822334 0.0722743750844336 2.16108710142123 0.27027027027027 1.3 1 3 eyelids open at birth 0.00126077606494491 0.0262441879627655 2.15277522795423 0.269230769230769 1.3 1 3 abnormal hair growth 0.00126077606494491 0.0262441879627655 2.15277522795423 0.269230769230769 1.3 1 3 small seminal vesicle 0.0203996577351682 0.161128112139528 2.15277522795423 0.269230769230769 1.3 1 3 pulmonary edema 0.0203996577351682 0.161128112139528 2.15277522795423 0.269230769230769 1.3 1 3 abnormal cornea morphology 8.7297021215511e-05 0.00358927835162948 2.15277522795423 0.269230769230769 1.3 1 3 disorganized myocardium 0.0143429083744362 0.124748197837098 2.13227260673561 0.266666666666667 1.3 1 3 liver hemorrhage 0.0143429083744362 0.124748197837098 2.13227260673561 0.266666666666667 1.3 1 3 abnormal fat pad morphology 0.0143429083744362 0.124748197837098 2.13227260673561 0.266666666666667 1.3 1 3 embryonic growth arrest 5.26065994667434e-11 1.4539879574836e-08 2.12994479821298 0.266375545851528 1.3 1 3 abnormal epidermis stratum corneum morphology 0.00214598728709257 0.0361908025535102 2.12139366486451 0.26530612244898 1.3 1 3 increased fluid intake 0.00214598728709257 0.0361908025535102 2.12139366486451 0.26530612244898 1.3 1 3 decreased mean corpuscular hemoglobin 0.000341636694825851 0.0107572313718899 2.11659413168609 0.264705882352941 1.3 1 3 abnormal nervous system development 0.0101328677666534 0.107946503509852 2.11659413168609 0.264705882352941 1.3 1 3 abnormal direction of heart looping 0.0101328677666534 0.107946503509852 2.11659413168609 0.264705882352941 1.3 1 3 abnormal cardiovascular system physiology 8.46174784071714e-07 7.6540355468305e-05 2.10421638822593 0.263157894736842 1.3 1 3 abnormal triglyceride level 0.052060888143586 0.290899037288757 2.10421638822593 0.263157894736842 1.3 1 3 flaky skin 0.052060888143586 0.290899037288757 2.10421638822593 0.263157894736842 1.3 1 3 thin dermal layer 0.052060888143586 0.290899037288757 2.10421638822593 0.263157894736842 1.3 1 3 delayed sexual maturation 0.052060888143586 0.290899037288757 2.10421638822593 0.263157894736842 1.3 1 3 decreased tumor incidence 0.052060888143586 0.290899037288757 2.10421638822593 0.263157894736842 1.3 1 3 abnormal nasal septum morphology 0.052060888143586 0.290899037288757 2.10421638822593 0.263157894736842 1.3 1 3 abnormal pancreas morphology 0.00511362830792872 0.0652315405947318 2.09419631018676 0.261904761904762 1.3 1 3 abnormal muscle morphology 0.00511362830792872 0.0652315405947318 2.09419631018676 0.261904761904762 1.3 1 3 thymus hypoplasia 7.46538348874641e-07 7.00760053896479e-05 2.08591885441527 0.260869565217391 1.3 1 3 atrial septal defect 0.00364857993658034 0.0537032106049917 2.08591885441527 0.260869565217391 1.3 1 3 abnormal pulmonary artery morphology 0.0358841391464592 0.224133858141094 2.08591885441527 0.260869565217391 1.3 1 3 abnormal cranial nerve morphology 0.0358841391464592 0.224133858141094 2.08591885441527 0.260869565217391 1.3 1 3 conjunctivitis 0.0358841391464592 0.224133858141094 2.08591885441527 0.260869565217391 1.3 1 3 abnormal hematopoietic stem cell physiology 0.0358841391464592 0.224133858141094 2.08591885441527 0.260869565217391 1.3 1 3 abnormal axon extension 0.00260937398416064 0.0413367968673572 2.07896579156722 0.26 1.3 1 3 abnormal maxilla morphology 0.00186994157851965 0.0332577451601639 2.07304281210407 0.259259259259259 1.3 1 3 abnormal neuronal precursor proliferation 0.00186994157851965 0.0332577451601639 2.07304281210407 0.259259259259259 1.3 1 3 abnormal heart valve morphology 0.0249664928013556 0.185109242454164 2.07304281210407 0.259259259259259 1.3 1 3 abnormal trigeminal nerve morphology 0.0249664928013556 0.185109242454164 2.07304281210407 0.259259259259259 1.3 1 3 abnormal type II pneumocyte morphology 0.0249664928013556 0.185109242454164 2.07304281210407 0.259259259259259 1.3 1 3 cryptorchism 0.0249664928013556 0.185109242454164 2.07304281210407 0.259259259259259 1.3 1 3 abnormal eye muscle morphology 0.0249664928013556 0.185109242454164 2.07304281210407 0.259259259259259 1.3 1 3 thick interventricular septum 0.0249664928013556 0.185109242454164 2.07304281210407 0.259259259259259 1.3 1 3 increased heart weight 9.00493201006334e-07 7.85956785088862e-05 2.07091224395186 0.258992805755396 1.3 1 3 abnormal podocyte morphology 0.0174932223255582 0.146021444747738 2.06348961942156 0.258064516129032 1.3 1 3 preaxial polydactyly 0.0174932223255582 0.146021444747738 2.06348961942156 0.258064516129032 1.3 1 3 abnormal mitochondrial ATP synthesis coupled electron transport 0.0174932223255582 0.146021444747738 2.06348961942156 0.258064516129032 1.3 1 3 abnormal kidney morphology 5.26226718639407e-08 6.88941559271329e-06 2.05612001363791 0.257142857142857 1.3 1 3 abnormal hippocampus pyramidal cell morphology 0.0123245066079628 0.114449888811311 2.05612001363791 0.257142857142857 1.3 1 3 decreased bone mineralization 0.0123245066079628 0.114449888811311 2.05612001363791 0.257142857142857 1.3 1 3 abnormal heart looping 0.00872141455134676 0.0955705669448241 2.05026212186117 0.256410256410256 1.3 1 3 abnormal circulating hormone level 0.00872141455134676 0.0955705669448241 2.05026212186117 0.256410256410256 1.3 1 3 anemia 3.09988982375622e-09 5.50783995470971e-07 2.04637536902352 0.255924170616114 1.3 1 3 abnormal axon guidance 0.00619410995935481 0.0755286692347798 2.04549407041498 0.255813953488372 1.3 1 3 abnormal double-strand DNA break repair 0.00619410995935481 0.0755286692347798 2.04549407041498 0.255813953488372 1.3 1 3 abnormal cervical vertebrae morphology 0.00315145072710984 0.0475105071738528 2.03820175643845 0.254901960784314 1.3 1 3 increased kidney weight 0.00315145072710984 0.0475105071738528 2.03820175643845 0.254901960784314 1.3 1 3 abnormal thrombosis 0.00315145072710984 0.0475105071738528 2.03820175643845 0.254901960784314 1.3 1 3 abnormal dendritic spine morphology 0.00315145072710984 0.0475105071738528 2.03820175643845 0.254901960784314 1.3 1 3 decreased susceptibility to hepatic steatosis 0.00116209283781445 0.0249198787419262 2.03073581593868 0.253968253968254 1.3 1 3 abnormal rib morphology 3.51125842232794e-06 0.000243646317543868 2.01381301747252 0.251851851851852 1.3 1 3 abnormal eating behavior 0.00193864243144674 0.0332577451601639 1.99900556881464 0.25 1.3 1 3 abnormal eye physiology 0.00193864243144674 0.0332577451601639 1.99900556881464 0.25 1.3 1 3 muscular ventricular septal defect 0.00193864243144674 0.0332577451601639 1.99900556881464 0.25 1.3 1 3 abnormal placenta vasculature 0.00378167561449814 0.0551378911981002 1.99900556881464 0.25 1.3 1 3 enlarged heart 2.13685942138429e-09 4.08879831591801e-07 1.99900556881464 0.25 1.3 1 3 insulin resistance 5.75376312462611e-06 0.000366986814679678 1.99900556881464 0.25 1.3 1 3 hydrops fetalis 0.000720619442785215 0.0178362275017734 1.99900556881464 0.25 1.3 1 3 decreased circulating LDL cholesterol level 0.00139185454060006 0.0270487357011144 1.99900556881464 0.25 1.3 1 3 overriding aortic valve 0.00529922116625988 0.0669127545739668 1.99900556881464 0.25 1.3 1 3 abnormal systemic arterial blood pressure 0.0148501405326871 0.128262932552289 1.99900556881464 0.25 1.3 1 3 abnormal epidermis stratum granulosum morphology 0.0148501405326871 0.128262932552289 1.99900556881464 0.25 1.3 1 3 renal hypoplasia 0.0148501405326871 0.128262932552289 1.99900556881464 0.25 1.3 1 3 abnormal diaphragm morphology 0.0211105962913803 0.161128112139528 1.99900556881464 0.25 1.3 1 3 decreased metastatic potential 0.043489035088988 0.261934563641302 1.99900556881464 0.25 1.3 1 3 decreased ovulation rate 0.043489035088988 0.261934563641302 1.99900556881464 0.25 1.3 1 3 abnormal hyoid bone morphology 0.0632875698605418 0.321548796131559 1.99900556881464 0.25 1.3 1 3 decreased skin tensile strength 0.0632875698605418 0.321548796131559 1.99900556881464 0.25 1.3 1 3 absent placental labyrinth 0.0632875698605418 0.321548796131559 1.99900556881464 0.25 1.3 1 3 abnormal male reproductive system physiology 0.0632875698605418 0.321548796131559 1.99900556881464 0.25 1.3 1 3 abnormal response to tactile stimuli 0.0632875698605418 0.321548796131559 1.99900556881464 0.25 1.3 1 3 abnormal sperm mitochondrial sheath morphology 0.0632875698605418 0.321548796131559 1.99900556881464 0.25 1.3 1 3 increased skin tumor incidence 0.0632875698605418 0.321548796131559 1.99900556881464 0.25 1.3 1 3 abnormal heart electrocardiography waveform feature 0.0632875698605418 0.321548796131559 1.99900556881464 0.25 1.3 1 3 abnormal seminal vesicle morphology 0.00270494123023933 0.0423178698755996 1.99900556881464 0.25 1.3 1 3 small superior cervical ganglion 0.0301861370574627 0.208642081239391 1.99900556881464 0.25 1.3 1 3 abnormal ovulation 0.0301861370574627 0.208642081239391 1.99900556881464 0.25 1.3 1 3 abnormal hormone level 0.0301861370574627 0.208642081239391 1.99900556881464 0.25 1.3 1 3 decreased cell proliferation 1.11377040983143e-07 1.31928756878842e-05 1.98820013330753 0.248648648648649 1.3 1 3 anophthalmia 0.000233116964383395 0.00811018809655518 1.97654483208638 0.247191011235955 1.3 1 3 abnormal lung development 0.000322464059775767 0.010554333535424 1.97548785624035 0.247058823529412 1.3 1 3 abnormal neural tube morphology 8.80425897763801e-07 7.82164078816948e-05 1.97432648771816 0.246913580246914 1.3 1 3 decreased heart weight 0.000446453237718673 0.0129134003351767 1.97432648771816 0.246913580246914 1.3 1 3 decreased total body fat amount 3.12879511014963e-12 9.7285972956215e-10 1.96309528913533 0.245508982035928 1.3 1 3 extramedullary hematopoiesis 7.60955170850998e-05 0.00318130418065858 1.96128848261059 0.245283018867925 1.3 1 3 cardiac hypertrophy 0.000144866142034922 0.00533858560462029 1.95820953679801 0.244897959183673 1.3 1 3 increased insulin sensitivity 5.08818623942199e-06 0.000334431813312265 1.9570683890493 0.244755244755245 1.3 1 3 prenatal lethality, complete penetrance 2.54677883768962e-10 6.33511235875293e-08 1.95586156373231 0.244604316546763 1.3 1 3 sparse hair 0.000529561063951702 0.0147009626754362 1.95024933542892 0.24390243902439 1.3 1 3 lethality at weaning, incomplete penetrance 0.0125298685304873 0.11522383722583 1.95024933542892 0.24390243902439 1.3 1 3 decreased T cell proliferation 4.37557088867655e-06 0.000294168448258998 1.94497839127911 0.243243243243243 1.3 1 3 abnormal intestine morphology 0.00101813431877975 0.0226603945883915 1.94497839127911 0.243243243243243 1.3 1 3 pale liver 0.00101813431877975 0.0226603945883915 1.94497839127911 0.243243243243243 1.3 1 3 increased white adipose tissue amount 0.0177368987131901 0.147807489276584 1.94497839127911 0.243243243243243 1.3 1 3 abnormal heart morphology 1.30362565411018e-08 2.00428307076468e-06 1.93842964248692 0.242424242424242 1.3 1 3 abnormal tooth development 0.0252267434965261 0.18565539777399 1.93842964248692 0.242424242424242 1.3 1 3 belly spot 0.0252267434965261 0.18565539777399 1.93842964248692 0.242424242424242 1.3 1 3 abnormal epidermis stratum basale morphology 0.0252267434965261 0.18565539777399 1.93842964248692 0.242424242424242 1.3 1 3 decreased circulating HDL cholesterol level 2.14526750284732e-05 0.0011476027770608 1.93653664478918 0.2421875 1.3 1 3 increased blood urea nitrogen level 7.08324839702736e-06 0.000440489509690139 1.93007434230379 0.241379310344828 1.3 1 3 glomerulosclerosis 0.00382405199036137 0.0553042402675809 1.93007434230379 0.241379310344828 1.3 1 3 abnormal middle ear morphology 0.0360916246723871 0.224133858141094 1.93007434230379 0.241379310344828 1.3 1 3 abnormal outer ear morphology 0.0360916246723871 0.224133858141094 1.93007434230379 0.241379310344828 1.3 1 3 short snout 0.000106142688830671 0.00419095140422688 1.92496832552521 0.240740740740741 1.3 1 3 abnormal somite development 0.000866978334676251 0.0202498460798796 1.9230939649356 0.240506329113924 1.3 1 3 abnormal placenta labyrinth morphology 0.000866978334676251 0.0202498460798796 1.9230939649356 0.240506329113924 1.3 1 3 decreased B cell proliferation 0.000866978334676251 0.0202498460798796 1.9230939649356 0.240506329113924 1.3 1 3 decreased heart rate 0.000201913731931678 0.00717514868828643 1.91904534606205 0.24 1.3 1 3 short stride length 0.00749426560178791 0.0851108776175784 1.91904534606205 0.24 1.3 1 3 increased B cell derived lymphoma incidence 0.00749426560178791 0.0851108776175784 1.91904534606205 0.24 1.3 1 3 decreased oocyte number 0.00749426560178791 0.0851108776175784 1.91904534606205 0.24 1.3 1 3 ruffled hair 0.0520283379014 0.290899037288757 1.91904534606205 0.24 1.3 1 3 mandible hypoplasia 0.0520283379014 0.290899037288757 1.91904534606205 0.24 1.3 1 3 abnormal feces composition 0.0520283379014 0.290899037288757 1.91904534606205 0.24 1.3 1 3 diaphragmatic hernia 0.0520283379014 0.290899037288757 1.91904534606205 0.24 1.3 1 3 increased liver glycogen level 0.0520283379014 0.290899037288757 1.91904534606205 0.24 1.3 1 3 abnormal CD4-positive, alpha-beta T cell physiology 0.00166983946108782 0.030654801914804 1.91454054478022 0.23943661971831 1.3 1 3 failure to gastrulate 0.0105317735344097 0.110772882312237 1.912092283214 0.239130434782609 1.3 1 3 abnormal myelin sheath morphology 0.0105317735344097 0.110772882312237 1.912092283214 0.239130434782609 1.3 1 3 small kidney 0.000532383525926659 0.0147009626754362 1.90814167932306 0.238636363636364 1.3 1 3 abnormal associative learning 0.0757621205619935 0.366463153904018 1.90381482744251 0.238095238095238 1.3 1 3 abnormal clavicle morphology 0.0757621205619935 0.366463153904018 1.90381482744251 0.238095238095238 1.3 1 3 embryonic lethality at implantation, complete penetrance 0.0757621205619935 0.366463153904018 1.90381482744251 0.238095238095238 1.3 1 3 increased muscle cell glucose uptake 0.0757621205619935 0.366463153904018 1.90381482744251 0.238095238095238 1.3 1 3 abnormal erythropoiesis 0.000172043180490621 0.00620228132565826 1.90381482744251 0.238095238095238 1.3 1 3 persistence of hyaloid vascular system 0.0210111202760751 0.161128112139528 1.89379474940334 0.236842105263158 1.3 1 3 increased grooming behavior 0.0210111202760751 0.161128112139528 1.89379474940334 0.236842105263158 1.3 1 3 decreased neuron apoptosis 0.0210111202760751 0.161128112139528 1.89379474940334 0.236842105263158 1.3 1 3 embryonic lethality between implantation and somite formation, complete penetrance 1.81463664978422e-08 2.65524039196368e-06 1.89293588557141 0.236734693877551 1.3 1 3 abnormal platelet physiology 0.00630405472319218 0.0763082049826791 1.88996890142475 0.236363636363636 1.3 1 3 abnormal neuromuscular synapse morphology 0.00196323473947225 0.0334489480440906 1.88794970388049 0.236111111111111 1.3 1 3 abnormal heart left ventricle morphology 0.00196323473947225 0.0334489480440906 1.88794970388049 0.236111111111111 1.3 1 3 decreased T cell number 5.18873856292166e-06 0.000335246420136821 1.88725991589953 0.236024844720497 1.3 1 3 short maxilla 0.0298710129518715 0.207553476865308 1.88141700594319 0.235294117647059 1.3 1 3 lung hemorrhage 0.0298710129518715 0.207553476865308 1.88141700594319 0.235294117647059 1.3 1 3 thin skin 0.0298710129518715 0.207553476865308 1.88141700594319 0.235294117647059 1.3 1 3 impaired hematopoiesis 0.00883051633245811 0.0961308944288383 1.88141700594319 0.235294117647059 1.3 1 3 abnormal gastrulation 0.00883051633245811 0.0961308944288383 1.88141700594319 0.235294117647059 1.3 1 3 abnormal gluconeogenesis 0.00883051633245811 0.0961308944288383 1.88141700594319 0.235294117647059 1.3 1 3 preweaning lethality, complete penetrance 3.26102821811226e-22 3.2447230770217e-19 1.88014577823647 0.235135135135135 1.3 1 3 decreased circulating cholesterol level 1.46635663891832e-06 0.000121585404643644 1.87884676413179 0.234972677595628 1.3 1 3 embryonic lethality during organogenesis, incomplete penetrance 7.40732208985984e-08 9.21285684926317e-06 1.87732696897375 0.234782608695652 1.3 1 3 increased sacral vertebrae number 0.0037971840704467 0.0551378911981002 1.87406772076372 0.234375 1.3 1 3 decreased hemoglobin content 2.51837216752527e-05 0.00130547328184691 1.87140946867753 0.234042553191489 1.3 1 3 increased respiratory quotient 0.0124015450286716 0.11447445765519 1.87140946867753 0.234042553191489 1.3 1 3 polyuria 0.00165722695086746 0.030535941039132 1.8692000123981 0.233766233766234 1.3 1 3 abnormal incisor morphology 0.00529319555815841 0.0669127545739668 1.86573853089366 0.233333333333333 1.3 1 3 increased metastatic potential 0.0427107991978505 0.258499058405482 1.86573853089366 0.233333333333333 1.3 1 3 abnormal optic cup morphology 0.0427107991978505 0.258499058405482 1.86573853089366 0.233333333333333 1.3 1 3 decreased bone marrow cell number 0.00229862534648149 0.0379922295639382 1.8620873791698 0.232876712328767 1.3 1 3 increased oxygen consumption 0.00101003472172981 0.0226603945883915 1.85954006401362 0.232558139534884 1.3 1 3 abnormal left-right axis patterning 0.017469665915395 0.146021444747738 1.85954006401362 0.232558139534884 1.3 1 3 abnormal homeostasis 0.017469665915395 0.146021444747738 1.85954006401362 0.232558139534884 1.3 1 3 impaired macrophage phagocytosis 0.017469665915395 0.146021444747738 1.85954006401362 0.232558139534884 1.3 1 3 preweaning lethality, incomplete penetrance 2.01841392177314e-12 7.17257804344385e-10 1.85726678765174 0.232273838630807 1.3 1 3 decreased cardiac muscle contractility 0.000378230608446405 0.0112676483653944 1.84523590967505 0.230769230769231 1.3 1 3 increased grip strength 0.000851977975319096 0.0201837639391072 1.84523590967505 0.230769230769231 1.3 1 3 abnormal snout morphology 0.0103451685478461 0.1095440880032 1.84523590967505 0.230769230769231 1.3 1 3 abnormal leukocyte cell number 0.0615169419512695 0.321548796131559 1.84523590967505 0.230769230769231 1.3 1 3 abnormal kidney cortex morphology 0.0615169419512695 0.321548796131559 1.84523590967505 0.230769230769231 1.3 1 3 heart inflammation 0.0615169419512695 0.321548796131559 1.84523590967505 0.230769230769231 1.3 1 3 decreased circulating glycerol level 0.0615169419512695 0.321548796131559 1.84523590967505 0.230769230769231 1.3 1 3 abnormal erythrocyte osmotic lysis 0.0615169419512695 0.321548796131559 1.84523590967505 0.230769230769231 1.3 1 3 decreased bone resorption 0.0615169419512695 0.321548796131559 1.84523590967505 0.230769230769231 1.3 1 3 decreased Peyer's patch number 0.0615169419512695 0.321548796131559 1.84523590967505 0.230769230769231 1.3 1 3 increased urine protein level 0.00193423177354845 0.0332577451601639 1.84523590967505 0.230769230769231 1.3 1 3 abnormal heart ventricle morphology 0.00193423177354845 0.0332577451601639 1.84523590967505 0.230769230769231 1.3 1 3 abnormal liver physiology 0.000520991227289994 0.0147009626754362 1.83908512330947 0.23 1.3 1 3 abnormal retinal pigmentation 0.00117659249718262 0.025122522203792 1.83816604028932 0.229885057471264 1.3 1 3 abnormal renal glomerulus morphology 0.000319333447842947 0.0105210854504547 1.8339500631327 0.229357798165138 1.3 1 3 abnormal embryonic epiblast morphology 0.0350699777945111 0.221412613613823 1.82766223434481 0.228571428571429 1.3 1 3 decreased glycogen level 0.0350699777945111 0.221412613613823 1.82766223434481 0.228571428571429 1.3 1 3 decreased bone volume 0.0350699777945111 0.221412613613823 1.82766223434481 0.228571428571429 1.3 1 3 impaired adaptive thermogenesis 0.0350699777945111 0.221412613613823 1.82766223434481 0.228571428571429 1.3 1 3 increased macrophage cell number 0.00862335422847807 0.0949141311652177 1.82365420312914 0.228070175438596 1.3 1 3 abnormal embryo development 7.43322039952168e-05 0.00316070696475388 1.82262272450746 0.227941176470588 1.3 1 3 increased leukocyte cell number 4.58537118164333e-05 0.00209286436960326 1.81978437988643 0.227586206896552 1.3 1 3 thrombocytopenia 4.58537118164333e-05 0.00209286436960326 1.81978437988643 0.227586206896552 1.3 1 3 abnormal suckling behavior 0.00136606572402261 0.0269906800615733 1.81727778983149 0.227272727272727 1.3 1 3 abnormal circadian rhythm 0.0204178717065631 0.161128112139528 1.81727778983149 0.227272727272727 1.3 1 3 increased activated T cell number 0.0894601209546059 0.41380847889257 1.81727778983149 0.227272727272727 1.3 1 3 abnormal tracheal cartilage morphology 0.0894601209546059 0.41380847889257 1.81727778983149 0.227272727272727 1.3 1 3 prolonged PR interval 0.0894601209546059 0.41380847889257 1.81727778983149 0.227272727272727 1.3 1 3 abnormal circulating lipid level 0.0894601209546059 0.41380847889257 1.81727778983149 0.227272727272727 1.3 1 3 abnormal limb posture 0.0894601209546059 0.41380847889257 1.81727778983149 0.227272727272727 1.3 1 3 abnormal sperm midpiece morphology 0.0894601209546059 0.41380847889257 1.81727778983149 0.227272727272727 1.3 1 3 increased adenoma incidence 0.0894601209546059 0.41380847889257 1.81727778983149 0.227272727272727 1.3 1 3 increased bone volume 0.0894601209546059 0.41380847889257 1.81727778983149 0.227272727272727 1.3 1 3 spleen hyperplasia 0.00311374212815836 0.0475105071738528 1.81243171572527 0.226666666666667 1.3 1 3 abnormal limb morphology 0.00311374212815836 0.0475105071738528 1.81243171572527 0.226666666666667 1.3 1 3 abnormal coat/ hair morphology 0.0120530023096861 0.114449888811311 1.81042013779439 0.226415094339623 1.3 1 3 prenatal lethality 0.00718528070033657 0.084332572838004 1.80555341699387 0.225806451612903 1.3 1 3 decreased thymus weight 0.0500659257856024 0.283507410637996 1.80555341699387 0.225806451612903 1.3 1 3 inner cell mass degeneration 0.0500659257856024 0.283507410637996 1.80555341699387 0.225806451612903 1.3 1 3 abnormal CD8-positive, alpha beta T cell morphology 0.0500659257856024 0.283507410637996 1.80555341699387 0.225806451612903 1.3 1 3 abnormal skeletal muscle fiber morphology 0.00431492877111406 0.0593321035056049 1.80192051273432 0.225352112676056 1.3 1 3 liver inflammation 0.000262458040484954 0.00884917156928513 1.79910501193317 0.225 1.3 1 3 abnormal retinal pigment epithelium morphology 0.00260594038833334 0.0413367968673572 1.79910501193317 0.225 1.3 1 3 abnormal craniofacial development 0.0168841705633738 0.142370760258957 1.79502540873151 0.224489795918367 1.3 1 3 rib fusion 0.00598602639985533 0.073350939259311 1.79015424072953 0.223880597014925 1.3 1 3 prenatal lethality, incomplete penetrance 1.32947419769315e-08 2.00428307076468e-06 1.78858392999204 0.223684210526316 1.3 1 3 decreased B cell number 2.88481382889875e-06 0.000207999257953207 1.78551953719366 0.223300970873786 1.3 1 3 neonatal lethality, incomplete penetrance 1.64778543544716e-07 1.82171834252213e-05 1.78372804601922 0.223076923076923 1.3 1 3 reduced fertility 0.000114255964512465 0.00440638312751562 1.78328554340299 0.223021582733813 1.3 1 3 abnormal long bone epiphyseal plate proliferative zone 0.0139689504817676 0.124748197837098 1.77689383894635 0.222222222222222 1.3 1 3 abnormal trigeminal ganglion morphology 0.0719599274226735 0.350637256540451 1.77689383894635 0.222222222222222 1.3 1 3 increased brain weight 0.0719599274226735 0.350637256540451 1.77689383894635 0.222222222222222 1.3 1 3 abnormal fetal cardiomyocyte proliferation 0.0719599274226735 0.350637256540451 1.77689383894635 0.222222222222222 1.3 1 3 decreased bone ossification 0.0719599274226735 0.350637256540451 1.77689383894635 0.222222222222222 1.3 1 3 increased circulating alkaline phosphatase level 3.65584866006617e-05 0.00174883145036819 1.77689383894634 0.222222222222222 1.3 1 3 microphthalmia 5.92487452482924e-05 0.0025856360316689 1.77689383894634 0.222222222222222 1.3 1 3 increased susceptibility to bacterial infection induced morbidity/mortality 0.00498684135158314 0.064700150217769 1.77689383894634 0.222222222222222 1.3 1 3 abnormal lysosome morphology 0.0408470741550324 0.250263785617347 1.77689383894634 0.222222222222222 1.3 1 3 abnormal ectoderm development 0.0237127514922475 0.177935050790243 1.77689383894634 0.222222222222222 1.3 1 3 increased inflammatory response 0.0015254380055153 0.0287464169599947 1.76754176610979 0.221052631578947 1.3 1 3 perinatal lethality, complete penetrance 3.2033604180306e-06 0.000227667401138604 1.76438050205236 0.220657276995305 1.3 1 3 decreased double-positive T cell number 0.00127579496729288 0.0264461665095087 1.75912490055688 0.22 1.3 1 3 increased body length 0.0195326052961288 0.155978669900868 1.75912490055688 0.22 1.3 1 3 reduced female fertility 1.41026221146806e-06 0.000118916178000908 1.75774627602666 0.219827586206897 1.3 1 3 respiratory distress 2.9690494426935e-05 0.00147710209774002 1.75635171364061 0.219653179190751 1.3 1 3 thick ventricular wall 0.0334034453730038 0.218035104423838 1.75522440188602 0.219512195121951 1.3 1 3 decreased hematocrit 0.000126483790341696 0.00480348745763309 1.75255282745393 0.219178082191781 1.3 1 3 seminiferous tubule degeneration 0.00574142830038359 0.0710537457572347 1.75255282745393 0.219178082191781 1.3 1 3 cyanosis 1.29887027492046e-05 0.000742744783647047 1.74912987271281 0.21875 1.3 1 3 kidney cortex cysts 0.0581734180439845 0.319087932490433 1.74912987271281 0.21875 1.3 1 3 polydipsia 0.0581734180439845 0.319087932490433 1.74912987271281 0.21875 1.3 1 3 bradykinesia 0.0581734180439845 0.319087932490433 1.74912987271281 0.21875 1.3 1 3 increased fatty acid level 0.0581734180439845 0.319087932490433 1.74912987271281 0.21875 1.3 1 3 pancreatic islet hyperplasia 0.0581734180439845 0.319087932490433 1.74912987271281 0.21875 1.3 1 3 abnormal lung morphology 0.000545869552690135 0.0149214342012825 1.74703007694725 0.218487394957983 1.3 1 3 postnatal lethality, incomplete penetrance 1.09135800925616e-13 4.93591463277216e-11 1.74561049671137 0.21830985915493 1.3 1 3 abnormal head morphology 0.0161079911585793 0.137456699852371 1.74458667823823 0.218181818181818 1.3 1 3 abnormal embryo turning 0.0161079911585793 0.137456699852371 1.74458667823823 0.218181818181818 1.3 1 3 abnormal learning/memory/conditioning 0.0161079911585793 0.137456699852371 1.74458667823823 0.218181818181818 1.3 1 3 abnormal liver morphology 2.85401907124795e-05 0.00143421665449077 1.74215010466527 0.217877094972067 1.3 1 3 abnormal inner ear morphology 0.0273741342583136 0.194551882764443 1.73826571201273 0.217391304347826 1.3 1 3 abnormal forelimb morphology 0.0273741342583136 0.194551882764443 1.73826571201273 0.217391304347826 1.3 1 3 delayed wound healing 0.0273741342583136 0.194551882764443 1.73826571201273 0.217391304347826 1.3 1 3 embryonic lethality between implantation and placentation, complete penetrance 0.0273741342583136 0.194551882764443 1.73826571201273 0.217391304347826 1.3 1 3 fragile skeleton 0.104342338123536 0.413872040164636 1.73826571201273 0.217391304347826 1.3 1 3 abnormal blood vessel physiology 0.104342338123536 0.413872040164636 1.73826571201273 0.217391304347826 1.3 1 3 abnormal postnatal growth 0.104342338123536 0.413872040164636 1.73826571201273 0.217391304347826 1.3 1 3 abnormal nasal cavity morphology 0.104342338123536 0.413872040164636 1.73826571201273 0.217391304347826 1.3 1 3 dilated heart 0.104342338123536 0.413872040164636 1.73826571201273 0.217391304347826 1.3 1 3 abnormal chondrocyte physiology 0.104342338123536 0.413872040164636 1.73826571201273 0.217391304347826 1.3 1 3 abnormal vertebral artery topology 0.104342338123536 0.413872040164636 1.73826571201273 0.217391304347826 1.3 1 3 epidermal hyperplasia 0.0132984577155006 0.12050970334174 1.73247149297269 0.216666666666667 1.3 1 3 absent mesoderm 0.0132984577155006 0.12050970334174 1.73247149297269 0.216666666666667 1.3 1 3 abnormal long bone epiphyseal plate morphology 0.0132984577155006 0.12050970334174 1.73247149297269 0.216666666666667 1.3 1 3 decreased erythrocyte cell number 0.000101782944980864 0.00405096121023838 1.73162265833625 0.21656050955414 1.3 1 3 decreased IgG level 0.0010204466110479 0.0226603945883915 1.72886968113698 0.216216216216216 1.3 1 3 small seminiferous tubules 0.00658581509240532 0.0795253157396031 1.72886968113698 0.216216216216216 1.3 1 3 abnormal vocalization 0.0472222949665749 0.279983351516511 1.72886968113698 0.216216216216216 1.3 1 3 increased insulin secretion 0.0472222949665749 0.279983351516511 1.72886968113698 0.216216216216216 1.3 1 3 abnormal chromosome morphology 0.0472222949665749 0.279983351516511 1.72886968113698 0.216216216216216 1.3 1 3 abnormal hair follicle development 0.0472222949665749 0.279983351516511 1.72886968113698 0.216216216216216 1.3 1 3 abnormal respiratory electron transport chain 0.0472222949665749 0.279983351516511 1.72886968113698 0.216216216216216 1.3 1 3 hyperglycemia 0.0033036857705073 0.0487710288079342 1.72641390033991 0.215909090909091 1.3 1 3 increased liver weight 0.0033036857705073 0.0487710288079342 1.72641390033991 0.215909090909091 1.3 1 3 small lung 0.0224756797611382 0.170192552224753 1.72463225544792 0.215686274509804 1.3 1 3 abnormal lipid homeostasis 0.000436822345755376 0.0127500549424083 1.72222018236338 0.215384615384615 1.3 1 3 abnormal response to infection 0.0054657987315788 0.0688413890876064 1.72066302125817 0.215189873417722 1.3 1 3 abnormal definitive hematopoiesis 0.00274993557209699 0.0428869262419515 1.7195746828513 0.21505376344086 1.3 1 3 polydactyly 0.0022898486318621 0.0379733231450464 1.71343334469826 0.214285714285714 1.3 1 3 reddish skin 0.0833527793404582 0.39455763769627 1.71343334469826 0.214285714285714 1.3 1 3 failure of blastocyst to hatch from the zona pellucida 0.0833527793404582 0.39455763769627 1.71343334469826 0.214285714285714 1.3 1 3 increased triglyceride level 0.0833527793404582 0.39455763769627 1.71343334469826 0.214285714285714 1.3 1 3 abnormal mitotic spindle morphology 0.0833527793404582 0.39455763769627 1.71343334469826 0.214285714285714 1.3 1 3 cleft palate 0.000497512146027563 0.014307068939232 1.70907346341404 0.213740458015267 1.3 1 3 decreased startle reflex 0.000971526916475344 0.0221713138048846 1.70855176821764 0.213675213675214 1.3 1 3 abnormal craniofacial morphology 0.00190741920254648 0.0332577451601639 1.70788825296785 0.213592233009709 1.3 1 3 abnormal muscle physiology 0.00377129249035364 0.0551378911981002 1.70701599134733 0.213483146067416 1.3 1 3 delayed bone ossification 0.00752739420135367 0.0851108776175784 1.70581808538849 0.213333333333333 1.3 1 3 abnormal neurocranium morphology 0.00752739420135367 0.0851108776175784 1.70581808538849 0.213333333333333 1.3 1 3 abnormal cell nucleus morphology 0.0314207799960546 0.216807739917298 1.70128133516139 0.212765957446809 1.3 1 3 abnormal posture 0.00623750653848631 0.0756868171438278 1.69915473349244 0.2125 1.3 1 3 abnormal embryo size 0.00132484668070614 0.0269906800615733 1.69827021775403 0.212389380530973 1.3 1 3 abnormal motor coordination/ balance 0.00260757068615397 0.0413367968673572 1.69612593717606 0.212121212121212 1.3 1 3 dextrocardia 0.0670436765759927 0.335555624713846 1.69612593717606 0.212121212121212 1.3 1 3 decreased brown adipose tissue amount 0.0670436765759927 0.335555624713846 1.69612593717606 0.212121212121212 1.3 1 3 abnormal skin condition 0.0257302071598264 0.188929360558835 1.69146625053546 0.211538461538462 1.3 1 3 atelectasis 0.0103709076280416 0.1095440880032 1.68930048068843 0.211267605633803 1.3 1 3 increased circulating free fatty acid level 0.0103709076280416 0.1095440880032 1.68930048068843 0.211267605633803 1.3 1 3 oxidative stress 0.00429244803718895 0.0593321035056049 1.68804914699903 0.211111111111111 1.3 1 3 abnormal blood homeostasis 0.00150430476451166 0.0284559551461806 1.68337311058075 0.210526315789474 1.3 1 3 abnormal craniofacial bone morphology 0.0211148182447819 0.161128112139528 1.68337311058075 0.210526315789474 1.3 1 3 increased bone marrow cell number 0.0542119415507082 0.30168278435657 1.68337311058075 0.210526315789474 1.3 1 3 impaired branching involved in ureteric bud morphogenesis 0.0542119415507082 0.30168278435657 1.68337311058075 0.210526315789474 1.3 1 3 abnormal retina morphology 2.54212648630399e-05 0.00130547328184691 1.67535704814941 0.20952380952381 1.3 1 3 abnormal organ of Corti morphology 0.0440215426858809 0.26450141891577 1.67358605761226 0.209302325581395 1.3 1 3 abnormal intestinal mucosa morphology 0.0440215426858809 0.26450141891577 1.67358605761226 0.209302325581395 1.3 1 3 postnatal growth retardation 1.11598765065925e-12 4.27079889386907e-10 1.6723706719495 0.209150326797386 1.3 1 3 decreased white adipose tissue amount 0.0142945761659161 0.124748197837098 1.67081062468089 0.208955223880597 1.3 1 3 small spleen 0.00487165095289135 0.064700150217769 1.66949915637266 0.208791208791209 1.3 1 3 abnormal kidney physiology 0.035870183490412 0.224133858141094 1.6658379740122 0.208333333333333 1.3 1 3 abnormal foregut morphology 0.12035636523789 0.434838719722951 1.6658379740122 0.208333333333333 1.3 1 3 abnormal startle reflex 0.12035636523789 0.434838719722951 1.6658379740122 0.208333333333333 1.3 1 3 blindness 0.12035636523789 0.434838719722951 1.6658379740122 0.208333333333333 1.3 1 3 abnormal sensory capabilities/reflexes/nociception 0.12035636523789 0.434838719722951 1.6658379740122 0.208333333333333 1.3 1 3 abnormal primitive streak formation 0.12035636523789 0.434838719722951 1.6658379740122 0.208333333333333 1.3 1 3 decreased fatty acid level 0.12035636523789 0.434838719722951 1.6658379740122 0.208333333333333 1.3 1 3 increased body temperature 0.12035636523789 0.434838719722951 1.6658379740122 0.208333333333333 1.3 1 3 increased circulating total protein level 0.12035636523789 0.434838719722951 1.6658379740122 0.208333333333333 1.3 1 3 abnormal lung saccule morphology 0.12035636523789 0.434838719722951 1.6658379740122 0.208333333333333 1.3 1 3 decreased body length 2.2662234412543e-06 0.000170825176064245 1.66340609375817 0.208029197080292 1.3 1 3 obese 0.0097328917644299 0.104807654822595 1.66151112213165 0.207792207792208 1.3 1 3 decreased body weight 9.34166484115476e-24 1.5491594194915e-20 1.65991738670553 0.207592891760905 1.3 1 3 increased circulating bilirubin level 0.0293123322396249 0.204528545430763 1.65955179297819 0.207547169811321 1.3 1 3 abnormal response/metabolism to endogenous compounds 0.00804534103033596 0.0895426658298017 1.65771193511458 0.207317073170732 1.3 1 3 abnormal embryonic neuroepithelium morphology 0.0240117744861625 0.179907497091353 1.65434943626039 0.206896551724138 1.3 1 3 lordosis 0.0956817762103899 0.413872040164636 1.65434943626039 0.206896551724138 1.3 1 3 abnormal circulating glucose level 0.0956817762103899 0.413872040164636 1.65434943626039 0.206896551724138 1.3 1 3 decreased bone strength 0.0956817762103899 0.413872040164636 1.65434943626039 0.206896551724138 1.3 1 3 increased double-positive T cell number 0.0956817762103899 0.413872040164636 1.65434943626039 0.206896551724138 1.3 1 3 decreased body size 1.75574975222368e-15 1.0918568771641e-12 1.65331287646323 0.206766917293233 1.3 1 3 premature death 1.35234376192526e-16 1.12131836926303e-13 1.65306848431594 0.206736353077816 1.3 1 3 cataract 0.00160280863975073 0.0297536305326861 1.65207071802863 0.206611570247934 1.3 1 3 increased circulating insulin level 0.000331716921492571 0.0107123648450191 1.64917959427208 0.20625 1.3 1 3 abnormal myocardial fiber morphology 0.00457029293314017 0.0612862731600333 1.64866438665125 0.206185567010309 1.3 1 3 abnormal vision 0.076681033811876 0.366463153904018 1.64623988020029 0.205882352941176 1.3 1 3 increased width of hypertrophic chondrocyte zone 0.076681033811876 0.366463153904018 1.64623988020029 0.205882352941176 1.3 1 3 decreased regulatory T cell number 0.076681033811876 0.366463153904018 1.64623988020029 0.205882352941176 1.3 1 3 increased susceptibility to weight gain 0.076681033811876 0.366463153904018 1.64623988020029 0.205882352941176 1.3 1 3 abnormal skin physiology 0.076681033811876 0.366463153904018 1.64623988020029 0.205882352941176 1.3 1 3 increased susceptibility to viral infection induced morbidity/mortality 0.076681033811876 0.366463153904018 1.64623988020029 0.205882352941176 1.3 1 3 abnormal coat/hair pigmentation 0.00261424032649568 0.0413367968673572 1.64204028866917 0.205357142857143 1.3 1 3 abnormal brain morphology 0.00037338420556947 0.0111902796548681 1.63893624275486 0.204968944099379 1.3 1 3 muscular atrophy 0.0500910580805625 0.283507410637996 1.63555001084834 0.204545454545455 1.3 1 3 abnormal photoreceptor outer segment morphology 0.0500910580805625 0.283507410637996 1.63555001084834 0.204545454545455 1.3 1 3 decreased macrophage cell number 0.0500910580805625 0.283507410637996 1.63555001084834 0.204545454545455 1.3 1 3 decreased leukocyte cell number 0.00104208484660815 0.022890101757515 1.63422353070978 0.204379562043796 1.3 1 3 decreased circulating creatinine level 0.0407383919332423 0.249905671846955 1.63184128066501 0.204081632653061 1.3 1 3 diluted coat color 0.0332373833869838 0.218035104423838 1.62881935236748 0.203703703703704 1.3 1 3 impaired limb coordination 0.0332373833869838 0.218035104423838 1.62881935236748 0.203703703703704 1.3 1 3 decreased platelet aggregation 0.0332373833869838 0.218035104423838 1.62881935236748 0.203703703703704 1.3 1 3 increased spleen weight 0.00294375203597523 0.0454818831645242 1.62750895868094 0.20353982300885 1.3 1 3 increased B cell proliferation 0.0271899336958866 0.194353333530224 1.62630961530682 0.203389830508475 1.3 1 3 abnormal osteoclast physiology 0.0222934138616507 0.169069716405049 1.62419202466189 0.203125 1.3 1 3 abnormal sternum morphology 0.0183145568919019 0.149111062929718 1.62238133121188 0.202898550724638 1.3 1 3 hyperkeratosis 0.0183145568919019 0.149111062929718 1.62238133121188 0.202898550724638 1.3 1 3 abnormal food intake 0.0183145568919019 0.149111062929718 1.62238133121188 0.202898550724638 1.3 1 3 increased granulocyte number 0.0150715586594716 0.129949747540505 1.62081532606592 0.202702702702703 1.3 1 3 abnormal nervous system morphology 0.0124214447301899 0.11447445765519 1.61944754941945 0.20253164556962 1.3 1 3 impaired glucose tolerance 2.22526897786341e-05 0.00117773544307133 1.6121012651731 0.201612903225806 1.3 1 3 increased tumor incidence 0.00228234212802724 0.0379733231450464 1.6121012651731 0.201612903225806 1.3 1 3 decreased circulating glucose level 8.54887348331604e-06 0.000518666409506065 1.60493637066121 0.200716845878136 1.3 1 3 embryonic lethality, complete penetrance 2.0664422767199e-06 0.000158162312718177 1.60421763516159 0.200626959247649 1.3 1 3 abnormal skeleton morphology 0.00370840918667783 0.0544228191850213 1.59920445505171 0.2 1.3 1 3 abnormal response to new environment 0.108924520463525 0.413872040164636 1.59920445505171 0.2 1.3 1 3 increased sensitivity to xenobiotic induced morbidity/mortality 0.00446999278592509 0.0602661628996676 1.59920445505171 0.2 1.3 1 3 decreased monocyte cell number 0.0251191923636393 0.18565539777399 1.59920445505171 0.2 1.3 1 3 increased circulating calcium level 0.0375197314440849 0.231588913069879 1.59920445505171 0.2 1.3 1 3 decreased circulating alkaline phosphatase level 0.0460398385925206 0.275629599275319 1.59920445505171 0.2 1.3 1 3 impaired ovarian folliculogenesis 0.0700801827495195 0.343835216152721 1.59920445505171 0.2 1.3 1 3 abnormal skin pigmentation 0.0700801827495195 0.343835216152721 1.59920445505171 0.2 1.3 1 3 increased susceptibility to weight loss 0.0700801827495195 0.343835216152721 1.59920445505171 0.2 1.3 1 3 abnormal dermal layer morphology 0.0870837978162172 0.409491393322949 1.59920445505171 0.2 1.3 1 3 increased circulating serum albumin level 0.0870837978162172 0.409491393322949 1.59920445505171 0.2 1.3 1 3 decreased triglyceride level 0.0870837978162172 0.409491393322949 1.59920445505171 0.2 1.3 1 3 increased red blood cell distribution width 0.0870837978162172 0.409491393322949 1.59920445505171 0.2 1.3 1 3 abnormal egg cylinder morphology 0.137438372072013 0.471881229163743 1.59920445505171 0.2 1.3 1 3 abnormal vertebrae development 0.137438372072013 0.471881229163743 1.59920445505171 0.2 1.3 1 3 decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 0.137438372072013 0.471881229163743 1.59920445505171 0.2 1.3 1 3 abnormal myocardial trabeculae morphology 0.0566856347276413 0.314393570535134 1.59920445505171 0.2 1.3 1 3 lethality at weaning, complete penetrance 0.0566856347276413 0.314393570535134 1.59920445505171 0.2 1.3 1 3 respiratory failure 0.00113951199923461 0.0246021660068254 1.58861369707124 0.198675496688742 1.3 1 3 increased neuron apoptosis 0.0156590688938201 0.134317013356474 1.57946119017453 0.197530864197531 1.3 1 3 abnormal maternal nurturing 0.0344432565989575 0.218565308137517 1.57298798857545 0.19672131147541 1.3 1 3 increased B cell number 0.00463269227004441 0.0619560323749219 1.57186762676023 0.196581196581197 1.3 1 3 impaired balance 0.00814138953595764 0.0904094038870296 1.56784750495266 0.196078431372549 1.3 1 3 abnormal mammary gland development 0.0789715130226143 0.376324978244738 1.56019946834313 0.195121951219512 1.3 1 3 increased bone mineral density 0.00622489217589664 0.0756868171438278 1.55674769960786 0.194690265486726 1.3 1 3 abnormal trophoblast giant cell morphology 0.0982443862861583 0.413872040164636 1.55478210907805 0.194444444444444 1.3 1 3 weight loss 0.000844044443958771 0.0200914885583487 1.55351289919309 0.194285714285714 1.3 1 3 abnormal cranium morphology 0.00328762911278358 0.0487710288079342 1.55146700863226 0.194029850746269 1.3 1 3 abnormal postnatal growth/weight/body size 0.123050583186226 0.442324170051644 1.54761721456617 0.193548387096774 1.3 1 3 abnormal nose morphology 0.123050583186226 0.442324170051644 1.54761721456617 0.193548387096774 1.3 1 3 decreased neuronal precursor cell number 0.123050583186226 0.442324170051644 1.54761721456617 0.193548387096774 1.3 1 3 decreased double-negative T cell number 0.123050583186226 0.442324170051644 1.54761721456617 0.193548387096774 1.3 1 3 small cranium 0.123050583186226 0.442324170051644 1.54761721456617 0.193548387096774 1.3 1 3 abnormal intestine physiology 0.123050583186226 0.442324170051644 1.54761721456617 0.193548387096774 1.3 1 3 increased circulating triglyceride level 0.00252469819288177 0.0406484579598279 1.54405947384303 0.193103448275862 1.3 1 3 decreased birth body size 0.00692251308377558 0.081804044161006 1.54309201803235 0.192982456140351 1.3 1 3 short tail 0.0195131521936394 0.155978669900868 1.54140188438719 0.192771084337349 1.3 1 3 abnormal vertebrae morphology 0.00835373150458969 0.0921503641581679 1.54051805303146 0.192660550458716 1.3 1 3 cachexia 0.0100893931918401 0.107946503509852 1.53769659139588 0.192307692307692 1.3 1 3 decreased IgA level 0.0579912389872498 0.319087932490433 1.53769659139588 0.192307692307692 1.3 1 3 abnormal female meiosis 0.0579912389872498 0.319087932490433 1.53769659139588 0.192307692307692 1.3 1 3 increased percent body fat/body weight 0.0579912389872498 0.319087932490433 1.53769659139588 0.192307692307692 1.3 1 3 ventricular hypoplasia 0.155514903053142 0.515447463483932 1.53769659139588 0.192307692307692 1.3 1 3 abnormal Schwann cell morphology 0.155514903053142 0.515447463483932 1.53769659139588 0.192307692307692 1.3 1 3 increased susceptibility to otitis media 0.155514903053142 0.515447463483932 1.53769659139588 0.192307692307692 1.3 1 3 increased thymocyte apoptosis 0.155514903053142 0.515447463483932 1.53769659139588 0.192307692307692 1.3 1 3 increased embryonic tissue cell apoptosis 0.0237071048371286 0.177935050790243 1.53769659139588 0.192307692307692 1.3 1 3 embryonic lethality before implantation, complete penetrance 0.00528881353787173 0.0669127545739668 1.53523627684964 0.192 1.3 1 3 increased body weight 0.000251077396906915 0.00861455206628896 1.53495070462553 0.191964285714286 1.3 1 3 increased mean corpuscular hemoglobin 0.0121970359580733 0.114449888811311 1.53459013363548 0.191919191919192 1.3 1 3 abnormal fertility/fecundity 0.0288496216036313 0.20395347353213 1.53348372402219 0.191780821917808 1.3 1 3 cleft secondary palate 0.0147601478872512 0.12815311647308 1.53115320164525 0.191489361702128 1.3 1 3 abnormal T-helper 1 physiology 0.0714878831800909 0.350396274700446 1.53115320164525 0.191489361702128 1.3 1 3 decreased circulating alanine transaminase level 0.0351731383879514 0.221782463219339 1.52865131732884 0.191176470588235 1.3 1 3 enlarged spleen 4.4146395129911e-05 0.00205260108197483 1.52701814284452 0.190972222222222 1.3 1 3 abnormal cartilage morphology 0.0885026518210486 0.41380847889257 1.52305186195401 0.19047619047619 1.3 1 3 gliosis 0.0429746319549827 0.259464555796163 1.52305186195401 0.19047619047619 1.3 1 3 increased or absent threshold for auditory brainstem response 4.87073104212835e-05 0.00218305287698996 1.52173434304228 0.190311418685121 1.3 1 3 increased sensitivity to induced morbidity/mortality 0.00105841092288009 0.0230947120233703 1.52098249801114 0.190217391304348 1.3 1 3 abnormal visceral yolk sac morphology 0.0263521814246925 0.189393521964911 1.51823207758074 0.189873417721519 1.3 1 3 reduced male fertility 0.00033805854887799 0.0107123648450191 1.51466501249391 0.18942731277533 1.3 1 3 abnormal long bone metaphysis morphology 0.110149540927394 0.413872040164636 1.51276097099486 0.189189189189189 1.3 1 3 increased erythroid progenitor cell number 0.110149540927394 0.413872040164636 1.51276097099486 0.189189189189189 1.3 1 3 no abnormal phenotype detected 7.08466746336717e-23 8.81155515756291e-20 1.51163994598548 0.189048991354467 1.3 1 3 enlarged kidney 0.0646607521843717 0.325847486475279 1.50868344816199 0.188679245283019 1.3 1 3 decreased spleen weight 0.03908673766382 0.240664009749387 1.50649695041103 0.188405797101449 1.3 1 3 perimembraneous ventricular septal defect 0.03908673766382 0.240664009749387 1.50649695041103 0.188405797101449 1.3 1 3 cardiac fibrosis 0.0240512118022309 0.179931998069322 1.50513360475455 0.188235294117647 1.3 1 3 abnormal osteoclast morphology 0.0797073523392473 0.378743149845038 1.49925417661098 0.1875 1.3 1 3 abnormal tooth morphology 0.0477472207457514 0.279983351516511 1.49925417661098 0.1875 1.3 1 3 abnormal serotonin level 0.138022236680589 0.473232686068871 1.49925417661098 0.1875 1.3 1 3 abnormal glucose homeostasis 0.00169832972658917 0.0310631999624306 1.49376240307028 0.186813186813187 1.3 1 3 kinked tail 0.0165425452519959 0.140203002774582 1.48945512970502 0.186274509803922 1.3 1 3 increased neutrophil cell number 0.004999908187877 0.064700150217769 1.48891449263435 0.186206896551724 1.3 1 3 hyperactivity 1.29595046149037e-05 0.000742744783647047 1.48713082747396 0.185983827493261 1.3 1 3 increased exploration in new environment 0.0322900039365085 0.218035104423838 1.48074486578862 0.185185185185185 1.3 1 3 abnormal chondrocyte morphology 0.0718024269110509 0.350637256540451 1.48074486578862 0.185185185185185 1.3 1 3 abnormal mandible morphology 0.0718024269110509 0.350637256540451 1.48074486578862 0.185185185185185 1.3 1 3 abnormal palate morphology 0.174504670241885 0.56188947043965 1.48074486578862 0.185185185185185 1.3 1 3 abnormal skin appearance 0.174504670241885 0.56188947043965 1.48074486578862 0.185185185185185 1.3 1 3 abnormal bone trabecula morphology 0.174504670241885 0.56188947043965 1.48074486578862 0.185185185185185 1.3 1 3 abnormal compact bone morphology 0.122780611754388 0.442324170051644 1.47295147175815 0.184210526315789 1.3 1 3 improved glucose tolerance 0.00172384704294927 0.0314144287130865 1.46865715259851 0.183673469387755 1.3 1 3 increased circulating LDL cholesterol level 0.0884753684305987 0.41380847889257 1.46865715259851 0.183673469387755 1.3 1 3 absent kidney 0.0884753684305987 0.41380847889257 1.46865715259851 0.183673469387755 1.3 1 3 increased bone mineral content 0.0166149026685474 0.140576770027251 1.46716005050616 0.18348623853211 1.3 1 3 abnormal behavior 0.000229620584629669 0.00804480569389157 1.46689617279923 0.183453237410072 1.3 1 3 abnormal kidney development 0.0647110184196132 0.325847486475279 1.46593741713073 0.183333333333333 1.3 1 3 ataxia 0.00157995903035703 0.0294393115206974 1.46461794150775 0.183168316831683 1.3 1 3 decreased liver weight 0.0478171407384199 0.279983351516511 1.46406041659664 0.183098591549296 1.3 1 3 abnormal testis morphology 0.0151392068223035 0.130082131158825 1.46014319809069 0.182608695652174 1.3 1 3 abnormal nervous system physiology 0.0151392068223035 0.130082131158825 1.46014319809069 0.182608695652174 1.3 1 3 decreased circulating calcium level 0.0794208036814877 0.377742350205929 1.45382223186519 0.181818181818182 1.3 1 3 abnormal T-helper 2 physiology 0.0794208036814877 0.377742350205929 1.45382223186519 0.181818181818182 1.3 1 3 hypertension 0.109465030124949 0.413872040164636 1.45382223186519 0.181818181818182 1.3 1 3 abnormal astrocyte morphology 0.109465030124949 0.413872040164636 1.45382223186519 0.181818181818182 1.3 1 3 renal interstitial fibrosis 0.109465030124949 0.413872040164636 1.45382223186519 0.181818181818182 1.3 1 3 embryonic lethality, incomplete penetrance 0.109465030124949 0.413872040164636 1.45382223186519 0.181818181818182 1.3 1 3 decreased systemic arterial blood pressure 0.153795250037166 0.511109798887711 1.45382223186519 0.181818181818182 1.3 1 3 abnormal QRS complex 0.153795250037166 0.511109798887711 1.45382223186519 0.181818181818182 1.3 1 3 cardiovascular system phenotype 0.153795250037166 0.511109798887711 1.45382223186519 0.181818181818182 1.3 1 3 limb grasping 0.0032239611928778 0.0480215776484043 1.44982821474468 0.181318681318681 1.3 1 3 small testis 0.000356689192172099 0.0108934676806607 1.44855476001061 0.181159420289855 1.3 1 3 spleen hypoplasia 0.0220089963658229 0.167167567816746 1.44689926885631 0.180952380952381 1.3 1 3 postnatal lethality 0.0050472737772255 0.0647169769115898 1.44506426661299 0.180722891566265 1.3 1 3 abnormal neural tube closure 0.0391487152247252 0.24074766161064 1.44506426661299 0.180722891566265 1.3 1 3 abnormal forebrain development 0.0526513265403818 0.293655100379372 1.44372624414391 0.180555555555556 1.3 1 3 decreased bone mineral density 0.000505414563447433 0.0144507899606378 1.44289123764064 0.180451127819549 1.3 1 3 abnormal hepatocyte morphology 0.0200011734825394 0.158955012900373 1.44072473428082 0.18018018018018 1.3 1 3 abnormal hindlimb morphology 0.0977904847365182 0.413872040164636 1.43928400954654 0.18 1.3 1 3 kidney inflammation 0.0977904847365182 0.413872040164636 1.43928400954654 0.18 1.3 1 3 increased circulating chloride level 0.0977904847365182 0.413872040164636 1.43928400954654 0.18 1.3 1 3 increased rib number 0.0475360274303369 0.279983351516511 1.43518348530282 0.179487179487179 1.3 1 3 small lens 0.136113900563858 0.471216150871718 1.43518348530282 0.179487179487179 1.3 1 3 abnormal iris morphology 0.136113900563858 0.471216150871718 1.43518348530282 0.179487179487179 1.3 1 3 abnormal response to injury 0.136113900563858 0.471216150871718 1.43518348530282 0.179487179487179 1.3 1 3 decreased compact bone thickness 0.0642012503572381 0.323936329135152 1.43212339258362 0.17910447761194 1.3 1 3 maternal effect 0.0642012503572381 0.323936329135152 1.43212339258362 0.17910447761194 1.3 1 3 increased food intake 0.0429435454845864 0.259464555796163 1.42786112058188 0.178571428571429 1.3 1 3 abnormal eye development 0.0875182268921685 0.411145589035447 1.42786112058188 0.178571428571429 1.3 1 3 shortened head 0.194320298698717 0.581941394461375 1.42786112058188 0.178571428571429 1.3 1 3 increased bone resorption 0.194320298698717 0.581941394461375 1.42786112058188 0.178571428571429 1.3 1 3 prolonged QRS complex duration 0.194320298698717 0.581941394461375 1.42786112058188 0.178571428571429 1.3 1 3 abnormal T cell differentiation 0.0290810955757738 0.20395347353213 1.42503367281836 0.178217821782178 1.3 1 3 abnormal pulmonary alveolus morphology 0.0290810955757738 0.20395347353213 1.42503367281836 0.178217821782178 1.3 1 3 astrocytosis 0.0578083626100111 0.319087932490433 1.42394917230632 0.178082191780822 1.3 1 3 decreased percent body fat/body weight 0.0578083626100111 0.319087932490433 1.42394917230632 0.178082191780822 1.3 1 3 increased T cell proliferation 0.026357338492912 0.189393521964911 1.41985442270946 0.177570093457944 1.3 1 3 increased circulating glucose level 0.012425368268101 0.11447445765519 1.41773444596783 0.177304964539007 1.3 1 3 hunched posture 0.0520987019546297 0.290899037288757 1.41701660574202 0.177215189873418 1.3 1 3 abnormal spleen red pulp morphology 0.170319724942586 0.555269090163411 1.41106275445739 0.176470588235294 1.3 1 3 abnormal bone structure 0.00452374866512827 0.0608260800243598 1.40862568579684 0.176165803108808 1.3 1 3 abnormal B cell differentiation 0.0424181404566693 0.257353961916988 1.40589402641909 0.175824175824176 1.3 1 3 decreased brain weight 0.0960948226078394 0.413872040164636 1.40281092548396 0.175438596491228 1.3 1 3 increased hepatocellular carcinoma incidence 0.0960948226078394 0.413872040164636 1.40281092548396 0.175438596491228 1.3 1 3 perinatal lethality 0.150121052827506 0.505654866497523 1.39930389817025 0.175 1.3 1 3 abnormal pancreatic beta cell morphology 0.150121052827506 0.505654866497523 1.39930389817025 0.175 1.3 1 3 abnormal hair follicle morphology 0.0859545864880214 0.405715434324389 1.39613087345784 0.174603174603175 1.3 1 3 abnormal epidermal layer morphology 0.077018364780968 0.367369477263007 1.39061256961018 0.173913043478261 1.3 1 3 abnormal coat appearance 0.077018364780968 0.367369477263007 1.39061256961018 0.173913043478261 1.3 1 3 abnormal spermatogenesis 0.0069681912412597 0.0821487000598744 1.39061256961018 0.173913043478261 1.3 1 3 abnormal locomotor behavior 0.046251179763504 0.276562042456048 1.39061256961018 0.173913043478261 1.3 1 3 postnatal lethality, complete penetrance 0.000151453261889194 0.00553676420446608 1.38791060218218 0.173575129533679 1.3 1 3 abnormal leukocyte migration 0.118041677852991 0.429595718594461 1.38392693225629 0.173076923076923 1.3 1 3 decreased kidney weight 0.118041677852991 0.429595718594461 1.38392693225629 0.173076923076923 1.3 1 3 increased susceptibility to injury 0.118041677852991 0.429595718594461 1.38392693225629 0.173076923076923 1.3 1 3 decreased body temperature 0.118041677852991 0.429595718594461 1.38392693225629 0.173076923076923 1.3 1 3 abnormal spleen morphology 0.00988287105500891 0.106192836930171 1.37862453021699 0.172413793103448 1.3 1 3 short limbs 0.0558757803414409 0.310594421451026 1.37862453021699 0.172413793103448 1.3 1 3 absent long term depression 0.214869990883785 0.589867840222085 1.37862453021699 0.172413793103448 1.3 1 3 short sternum 0.214869990883785 0.589867840222085 1.37862453021699 0.172413793103448 1.3 1 3 abnormal CD8-positive, alpha-beta T cell physiology 0.214869990883785 0.589867840222085 1.37862453021699 0.172413793103448 1.3 1 3 abnormal enzyme/coenzyme activity 0.0142710943118477 0.124748197837098 1.37511211103173 0.171974522292994 1.3 1 3 abnormal lens morphology 0.0252219821628342 0.18565539777399 1.37431632856006 0.171875 1.3 1 3 abnormal humoral immune response 0.0409300683468303 0.250463825369595 1.37074667575861 0.171428571428571 1.3 1 3 domed cranium 0.0839949143644411 0.396842069290688 1.37074667575861 0.171428571428571 1.3 1 3 dehydration 0.0839949143644411 0.396842069290688 1.37074667575861 0.171428571428571 1.3 1 3 increased carcinoma incidence 0.187540951244593 0.581941394461375 1.37074667575861 0.171428571428571 1.3 1 3 abnormal intestinal goblet cell morphology 0.187540951244593 0.581941394461375 1.37074667575861 0.171428571428571 1.3 1 3 holoprosencephaly 0.187540951244593 0.581941394461375 1.37074667575861 0.171428571428571 1.3 1 3 neonatal lethality, complete penetrance 7.60026312784855e-05 0.00318130418065858 1.36774065234686 0.171052631578947 1.3 1 3 decreased anxiety-related response 0.0301954368828868 0.208642081239391 1.36517453480024 0.170731707317073 1.3 1 3 Leydig cell hyperplasia 0.164769487493219 0.54394704729845 1.36517453480024 0.170731707317073 1.3 1 3 arrested B cell differentiation 0.164769487493219 0.54394704729845 1.36517453480024 0.170731707317073 1.3 1 3 increased cellular sensitivity to gamma-irradiation 0.145484948475002 0.490703470280091 1.36102506812912 0.170212765957447 1.3 1 3 abnormal innervation 0.145484948475002 0.490703470280091 1.36102506812912 0.170212765957447 1.3 1 3 increased systemic arterial blood pressure 0.145484948475002 0.490703470280091 1.36102506812912 0.170212765957447 1.3 1 3 increased monocyte cell number 0.0492144582115907 0.283507410637996 1.35932378679395 0.17 1.3 1 3 azoospermia 0.0166846820313634 0.140927492539954 1.35781510334579 0.169811320754717 1.3 1 3 abnormal mesoderm development 0.128960503557935 0.462565612978175 1.35781510334579 0.169811320754717 1.3 1 3 abnormal pancreatic islet morphology 0.128960503557935 0.462565612978175 1.35781510334579 0.169811320754717 1.3 1 3 reduced long term potentiation 0.0400378491554206 0.245911480923725 1.35646806455279 0.169642857142857 1.3 1 3 abnormal colon morphology 0.114674956863473 0.418807609008169 1.35525801275569 0.169491525423729 1.3 1 3 abnormal ovary morphology 0.0913531056104115 0.413872040164636 1.35144038455074 0.169014084507042 1.3 1 3 abnormal cytokine secretion 0.0198631751630906 0.158110874298201 1.34997778673196 0.168831168831169 1.3 1 3 increased startle reflex 0.0658477404648397 0.330901524053109 1.34764420369526 0.168539325842697 1.3 1 3 decreased rib number 0.0658477404648397 0.330901524053109 1.34764420369526 0.168539325842697 1.3 1 3 decreased bone mineral content 0.00832028141497861 0.0919853334211525 1.34548451747139 0.168269230769231 1.3 1 3 decreased litter size 0.00288728555473466 0.0447484287688626 1.33741297842403 0.167259786476868 1.3 1 3 male infertility 9.68347929040646e-05 0.00388510560240098 1.33531982330361 0.166998011928429 1.3 1 3 abnormal digit morphology 0.0990934614244177 0.413872040164636 1.33267037920976 0.166666666666667 1.3 1 3 abnormal tail morphology 0.111016340240255 0.413872040164636 1.33267037920976 0.166666666666667 1.3 1 3 abnormal small intestine morphology 0.140392118887312 0.476202746492064 1.33267037920976 0.166666666666667 1.3 1 3 neurodegeneration 0.140392118887312 0.476202746492064 1.33267037920976 0.166666666666667 1.3 1 3 abnormal cardiovascular system morphology 0.158640467702153 0.525107336539062 1.33267037920976 0.166666666666667 1.3 1 3 thymus atrophy 0.158640467702153 0.525107336539062 1.33267037920976 0.166666666666667 1.3 1 3 abnormal reproductive system morphology 0.180022854627653 0.567922448809495 1.33267037920976 0.166666666666667 1.3 1 3 heart right ventricle hypertrophy 0.20540026423628 0.581941394461375 1.33267037920976 0.166666666666667 1.3 1 3 abnormal uterus morphology 0.20540026423628 0.581941394461375 1.33267037920976 0.166666666666667 1.3 1 3 reduced long term depression 0.20540026423628 0.581941394461375 1.33267037920976 0.166666666666667 1.3 1 3 abnormal limb bone morphology 0.20540026423628 0.581941394461375 1.33267037920976 0.166666666666667 1.3 1 3 narrow eye opening 0.20540026423628 0.581941394461375 1.33267037920976 0.166666666666667 1.3 1 3 abnormal hair cycle 0.236059084967837 0.619079571805477 1.33267037920976 0.166666666666667 1.3 1 3 emphysema 0.236059084967837 0.619079571805477 1.33267037920976 0.166666666666667 1.3 1 3 abnormal pain threshold 0.236059084967837 0.619079571805477 1.33267037920976 0.166666666666667 1.3 1 3 enhanced paired-pulse facilitation 0.236059084967837 0.619079571805477 1.33267037920976 0.166666666666667 1.3 1 3 abnormal synaptic transmission 0.236059084967837 0.619079571805477 1.33267037920976 0.166666666666667 1.3 1 3 abnormal microglial cell physiology 0.236059084967837 0.619079571805477 1.33267037920976 0.166666666666667 1.3 1 3 abnormal bone mineralization 0.0454457930205245 0.272729578138853 1.3216565744229 0.165289256198347 1.3 1 3 increased circulating cholesterol level 0.0198326576599973 0.158110874298201 1.31752639762783 0.164772727272727 1.3 1 3 abnormal contextual conditioning behavior 0.152321289253669 0.510527644832276 1.30844000867867 0.163636363636364 1.3 1 3 abnormal long bone hypertrophic chondrocyte zone 0.172331218779529 0.561091500934658 1.30547302453201 0.163265306122449 1.3 1 3 increased T cell derived lymphoma incidence 0.172331218779529 0.561091500934658 1.30547302453201 0.163265306122449 1.3 1 3 abnormal male reproductive system morphology 0.195841511434041 0.581941394461375 1.30167804480953 0.162790697674419 1.3 1 3 decreased oxygen consumption 0.195841511434041 0.581941394461375 1.30167804480953 0.162790697674419 1.3 1 3 increased brown adipose tissue amount 0.223835888102516 0.59422814477589 1.29665226085274 0.162162162162162 1.3 1 3 decreased circulating chloride level 0.223835888102516 0.59422814477589 1.29665226085274 0.162162162162162 1.3 1 3 decreased width of hypertrophic chondrocyte zone 0.223835888102516 0.59422814477589 1.29665226085274 0.162162162162162 1.3 1 3 lung inflammation 0.0458777798155944 0.274990306726003 1.29347419158594 0.161764705882353 1.3 1 3 female infertility 0.00776174600457986 0.0875616471038204 1.29259006705307 0.161654135338346 1.3 1 3 hypoglycemia 0.0891940008470494 0.41380847889257 1.28968101213848 0.161290322580645 1.3 1 3 lethargy 0.0891940008470494 0.41380847889257 1.28968101213848 0.161290322580645 1.3 1 3 abnormal cranial ganglia morphology 0.257791489156608 0.66128634260312 1.28968101213848 0.161290322580645 1.3 1 3 abnormal retinal photoreceptor layer morphology 0.257791489156608 0.66128634260312 1.28968101213848 0.161290322580645 1.3 1 3 short mandible 0.164730386301616 0.54394704729845 1.2850750085237 0.160714285714286 1.3 1 3 abnormal trabecular bone morphology 0.0669676762828735 0.335555624713846 1.27667582546145 0.159663865546218 1.3 1 3 hypoactivity 0.00281364325493963 0.0437433599791395 1.27257648943107 0.159151193633952 1.3 1 3 osteoporosis 0.212183007897923 0.587363843684855 1.27209445288204 0.159090909090909 1.3 1 3 cochlear hair cell degeneration 0.212183007897923 0.587363843684855 1.27209445288204 0.159090909090909 1.3 1 3 impaired coordination 0.00419321593405263 0.0584348719101172 1.27104400329254 0.158959537572254 1.3 1 3 abnormal developmental patterning 0.119485930751936 0.434533995241874 1.26766206802879 0.158536585365854 1.3 1 3 abnormal frontal bone morphology 0.24278375241779 0.636044849014484 1.26252983293556 0.157894736842105 1.3 1 3 decreased threshold for auditory brainstem response 0.24278375241779 0.636044849014484 1.26252983293556 0.157894736842105 1.3 1 3 thick epidermis 0.150246033098772 0.505733433468464 1.25651778611206 0.157142857142857 1.3 1 3 increased total body fat amount 0.0663453760829795 0.333065838559862 1.25310796851067 0.156716417910448 1.3 1 3 decreased lymphocyte cell number 0.0735492585884066 0.358030882071745 1.24937848050915 0.15625 1.3 1 3 increased circulating follicle stimulating hormone level 0.279970980355871 0.686522919928321 1.24937848050915 0.15625 1.3 1 3 neonatal lethality 0.279970980355871 0.686522919928321 1.24937848050915 0.15625 1.3 1 3 abnormal lumbar vertebrae morphology 0.279970980355871 0.686522919928321 1.24937848050915 0.15625 1.3 1 3 decreased susceptibility to parasitic infection 0.279970980355871 0.686522919928321 1.24937848050915 0.15625 1.3 1 3 abnormal auditory brainstem response waveform shape 0.279970980355871 0.686522919928321 1.24937848050915 0.15625 1.3 1 3 abnormal autopod morphology 0.229002574114816 0.603436338040894 1.24382568726244 0.155555555555556 1.3 1 3 increased circulating corticosterone level 0.229002574114816 0.603436338040894 1.24382568726244 0.155555555555556 1.3 1 3 abnormal metabolism 0.229002574114816 0.603436338040894 1.24382568726244 0.155555555555556 1.3 1 3 cardiomyopathy 0.229002574114816 0.603436338040894 1.24382568726244 0.155555555555556 1.3 1 3 abnormal gait 0.0107623100922438 0.111779734256603 1.24210054761298 0.155339805825243 1.3 1 3 decreased grip strength 0.0282285844978211 0.200338384988102 1.2413915861132 0.155251141552511 1.3 1 3 decreased exploration in new environment 0.136965370037397 0.471232860260062 1.23747963783763 0.154761904761905 1.3 1 3 decreased neutrophil cell number 0.0965035779949803 0.413872040164636 1.2301572731167 0.153846153846154 1.3 1 3 increased circulating alanine transaminase level 0.15341662577057 0.510875310045909 1.2301572731167 0.153846153846154 1.3 1 3 absent gastric milk in neonates 0.15341662577057 0.510875310045909 1.2301572731167 0.153846153846154 1.3 1 3 kinked neural tube 0.216325617336884 0.589867840222085 1.2301572731167 0.153846153846154 1.3 1 3 acanthosis 0.262178270936687 0.66128634260312 1.2301572731167 0.153846153846154 1.3 1 3 impaired macrophage chemotaxis 0.262178270936687 0.66128634260312 1.2301572731167 0.153846153846154 1.3 1 3 abnormal spatial learning 0.0602166554320522 0.321548796131559 1.22638378454886 0.153374233128834 1.3 1 3 abnormal thoracic vertebrae morphology 0.204628639766255 0.581941394461375 1.21973221148012 0.152542372881356 1.3 1 3 abnormal immune system morphology 0.246253602206476 0.64411759777982 1.21678599840891 0.152173913043478 1.3 1 3 abnormal lymphocyte physiology 0.246253602206476 0.64411759777982 1.21678599840891 0.152173913043478 1.3 1 3 decreased food intake 0.163731607304206 0.541598900490973 1.21458566206459 0.151898734177215 1.3 1 3 increased cardiomyocyte apoptosis 0.302502360769925 0.691801147065167 1.21151852655433 0.151515151515152 1.3 1 3 abnormal locomotor coordination 0.302502360769925 0.691801147065167 1.21151852655433 0.151515151515152 1.3 1 3 abnormal T cell subpopulation ratio 0.302502360769925 0.691801147065167 1.21151852655433 0.151515151515152 1.3 1 3 increased osteoblast cell number 0.302502360769925 0.691801147065167 1.21151852655433 0.151515151515152 1.3 1 3 abnormal middle ear ossicle morphology 0.302502360769925 0.691801147065167 1.21151852655433 0.151515151515152 1.3 1 3 decreased sensitivity to xenobiotic induced morbidity/mortality 0.302502360769925 0.691801147065167 1.21151852655433 0.151515151515152 1.3 1 3 abnormal placenta development 0.231857193119808 0.610635010995789 1.20694675852959 0.150943396226415 1.3 1 3 increased erythrocyte cell number 0.218739385980492 0.589867840222085 1.19940334128878 0.15 1.3 1 3 abnormal female reproductive system morphology 0.281953074132424 0.686522919928321 1.19940334128878 0.15 1.3 1 3 abnormal dendritic cell physiology 0.134581893722072 0.471216150871718 1.19566688228165 0.149532710280374 1.3 1 3 seizures 0.128312673021618 0.460906533055993 1.19238928666136 0.149122807017544 1.3 1 3 pulmonary hypoplasia 0.263888116609484 0.66128634260312 1.19089693461298 0.148936170212766 1.3 1 3 abnormal osteoblast physiology 0.247764162551546 0.64480380668358 1.1845958926309 0.148148148148148 1.3 1 3 axon degeneration 0.247764162551546 0.64480380668358 1.1845958926309 0.148148148148148 1.3 1 3 abnormal long bone morphology 0.233212266729993 0.613554218393293 1.17974099143159 0.147540983606557 1.3 1 3 increased double-negative T cell number 0.233212266729993 0.613554218393293 1.17974099143159 0.147540983606557 1.3 1 3 impaired righting response 0.166949489385133 0.550676607242655 1.17836117740652 0.147368421052632 1.3 1 3 decreased susceptibility to injury 0.219967933587516 0.589867840222085 1.17588562871449 0.147058823529412 1.3 1 3 abnormal oocyte morphology 0.325292470395329 0.724409149604637 1.17588562871449 0.147058823529412 1.3 1 3 abnormal endoderm development 0.325292470395329 0.724409149604637 1.17588562871449 0.147058823529412 1.3 1 3 impaired synaptic plasticity 0.325292470395329 0.724409149604637 1.17588562871449 0.147058823529412 1.3 1 3 abnormal bone remodeling 0.325292470395329 0.724409149604637 1.17588562871449 0.147058823529412 1.3 1 3 decreased osteoblast cell number 0.325292470395329 0.724409149604637 1.17588562871449 0.147058823529412 1.3 1 3 abnormal cholesterol homeostasis 0.30204168898486 0.691801147065167 1.17014960125735 0.146341463414634 1.3 1 3 abnormal intestinal epithelium morphology 0.281857227398541 0.686522919928321 1.16608658180854 0.145833333333333 1.3 1 3 abnormal hair shaft morphology 0.281857227398541 0.686522919928321 1.16608658180854 0.145833333333333 1.3 1 3 abnormal axial skeleton morphology 0.220355767667274 0.589867840222085 1.15731901352426 0.144736842105263 1.3 1 3 abnormal lipid level 0.208250753202523 0.581941394461375 1.15605141329039 0.144578313253012 1.3 1 3 decreased insulin secretion 0.197089155704347 0.581941394461375 1.15498099531512 0.144444444444444 1.3 1 3 increased susceptibility to parasitic infection 0.197089155704347 0.581941394461375 1.15498099531512 0.144444444444444 1.3 1 3 decreased IgM level 0.186754624297459 0.581941394461375 1.15406507065587 0.144329896907216 1.3 1 3 increased anxiety-related response 0.137761271314918 0.47266367227015 1.15050680219548 0.143884892086331 1.3 1 3 arrest of spermatogenesis 0.22013165039671 0.589867840222085 1.14228889646551 0.142857142857143 1.3 1 3 abnormal nervous system electrophysiology 0.22013165039671 0.589867840222085 1.14228889646551 0.142857142857143 1.3 1 3 organ of Corti degeneration 0.300111562168376 0.690589741807432 1.14228889646551 0.142857142857143 1.3 1 3 abnormal respiratory system physiology 0.300111562168376 0.690589741807432 1.14228889646551 0.142857142857143 1.3 1 3 decreased urine osmolality 0.300111562168376 0.690589741807432 1.14228889646551 0.142857142857143 1.3 1 3 abnormal vibrissa morphology 0.322378161377728 0.721488848426874 1.14228889646551 0.142857142857143 1.3 1 3 spina bifida 0.322378161377728 0.721488848426874 1.14228889646551 0.142857142857143 1.3 1 3 impaired fertilization 0.247433717398605 0.64480380668358 1.14228889646551 0.142857142857143 1.3 1 3 skin lesions 0.263130979181409 0.66128634260312 1.14228889646551 0.142857142857143 1.3 1 3 increased circulating aspartate transaminase level 0.263130979181409 0.66128634260312 1.14228889646551 0.142857142857143 1.3 1 3 enhanced long term potentiation 0.280556319957319 0.686522919928321 1.14228889646551 0.142857142857143 1.3 1 3 decreased circulating thyroxine level 0.348251056920452 0.768658249632144 1.14228889646551 0.142857142857143 1.3 1 3 abnormal eye electrophysiology 0.185958458884991 0.581941394461375 1.12340808825947 0.140495867768595 1.3 1 3 decreased susceptibility to induced arthritis 0.297365587788032 0.686522919928321 1.12224874038717 0.140350877192982 1.3 1 3 infertility 0.206796944127528 0.581941394461375 1.12093770213905 0.14018691588785 1.3 1 3 enlarged liver 0.218432456344365 0.589867840222085 1.1194431185362 0.14 1.3 1 3 testicular atrophy 0.318601672827242 0.715918393096445 1.1194431185362 0.14 1.3 1 3 increased circulating creatinine level 0.244692585277558 0.640708216713605 1.11572403840817 0.13953488372093 1.3 1 3 abnormal blood circulation 0.342897618125353 0.761569486684656 1.11572403840817 0.13953488372093 1.3 1 3 dermatitis 0.314398979189821 0.706793909385161 1.10289962417359 0.137931034482759 1.3 1 3 thrombocytosis 0.314398979189821 0.706793909385161 1.10289962417359 0.137931034482759 1.3 1 3 abnormal cued conditioning behavior 0.337278414439824 0.749423899883039 1.09749325346686 0.137254901960784 1.3 1 3 abnormal response to novel object 0.337278414439824 0.749423899883039 1.09749325346686 0.137254901960784 1.3 1 3 abnormal immune system physiology 0.214032803339765 0.589867840222085 1.0962288603177 0.137096774193548 1.3 1 3 abnormal seminiferous tubule morphology 0.191477077095028 0.581941394461375 1.09534551715871 0.136986301369863 1.3 1 3 abnormal motor capabilities/coordination/movement 0.212277425315652 0.587363843684855 1.09036667389889 0.136363636363636 1.3 1 3 increased T cell number 0.270210126892856 0.676204920166981 1.09036667389889 0.136363636363636 1.3 1 3 teratozoospermia 0.270210126892856 0.676204920166981 1.09036667389889 0.136363636363636 1.3 1 3 abnormal skin morphology 0.309993223922854 0.697519805072907 1.09036667389889 0.136363636363636 1.3 1 3 abnormal myelopoiesis 0.363536767108631 0.777499907058603 1.09036667389889 0.136363636363636 1.3 1 3 abnormal amino acid level 0.363536767108631 0.777499907058603 1.09036667389889 0.136363636363636 1.3 1 3 abnormal branching of the mammary ductal tree 0.39433144786133 0.799754974769717 1.08054355071062 0.135135135135135 1.3 1 3 impaired skeletal muscle contractility 0.39433144786133 0.799754974769717 1.08054355071062 0.135135135135135 1.3 1 3 abnormal calcium ion homeostasis 0.39433144786133 0.799754974769717 1.08054355071062 0.135135135135135 1.3 1 3 abnormal humerus morphology 0.39433144786133 0.799754974769717 1.08054355071062 0.135135135135135 1.3 1 3 increased trabecular bone volume 0.39433144786133 0.799754974769717 1.08054355071062 0.135135135135135 1.3 1 3 absent corpus luteum 0.35609329398917 0.775980787383321 1.07638761397711 0.134615384615385 1.3 1 3 abnormal neuron differentiation 0.260671035080059 0.66128634260312 1.07089584043641 0.133928571428571 1.3 1 3 altered response to myocardial infarction 0.384234335261527 0.791211017353516 1.06613630336781 0.133333333333333 1.3 1 3 abnormal ovarian follicle morphology 0.384234335261527 0.791211017353516 1.06613630336781 0.133333333333333 1.3 1 3 irregular heartbeat 0.384234335261527 0.791211017353516 1.06613630336781 0.133333333333333 1.3 1 3 decreased osteoclast cell number 0.384234335261527 0.791211017353516 1.06613630336781 0.133333333333333 1.3 1 3 decreased hair follicle number 0.41729321989823 0.843230612913767 1.05210819411297 0.131578947368421 1.3 1 3 abnormal retinal outer nuclear layer morphology 0.41729321989823 0.843230612913767 1.05210819411297 0.131578947368421 1.3 1 3 abnormal CNS synaptic transmission 0.304911911710817 0.691801147065167 1.04998272301375 0.131313131313131 1.3 1 3 increased osteoclast cell number 0.366458718977974 0.777499907058603 1.0486586590503 0.131147540983607 1.3 1 3 abnormal male meiosis 0.366458718977974 0.777499907058603 1.0486586590503 0.131147540983607 1.3 1 3 abnormal NK cell physiology 0.366458718977974 0.777499907058603 1.0486586590503 0.131147540983607 1.3 1 3 decreased inflammatory response 0.32950464133908 0.73280536015285 1.04709815509338 0.130952380952381 1.3 1 3 hydroencephaly 0.295213762837809 0.686522919928321 1.04295942720764 0.130434782608696 1.3 1 3 abnormal cochlea morphology 0.393948625372859 0.799754974769717 1.03652140605203 0.12962962962963 1.3 1 3 polyphagia 0.393948625372859 0.799754974769717 1.03652140605203 0.12962962962963 1.3 1 3 abnormal excitatory postsynaptic currents 0.366420430341547 0.777499907058603 1.02513106093058 0.128205128205128 1.3 1 3 abnormal lens fiber morphology 0.440104241804339 0.853929474613872 1.02513106093058 0.128205128205128 1.3 1 3 decreased B-1 B cell number 0.440104241804339 0.853929474613872 1.02513106093058 0.128205128205128 1.3 1 3 neuron degeneration 0.425571932333486 0.853929474613872 1.02076880109684 0.127659574468085 1.3 1 3 decreased bone trabecula number 0.425571932333486 0.853929474613872 1.02076880109684 0.127659574468085 1.3 1 3 abnormal joint morphology 0.412898043530453 0.835188232426901 1.01767556230563 0.127272727272727 1.3 1 3 increased susceptibility to pharmacologically induced seizures 0.378979357544616 0.782199824502399 0.999502784407319 0.125 1.3 1 3 abnormal urine homeostasis 0.378979357544616 0.782199824502399 0.999502784407319 0.125 1.3 1 3 abnormal inflammatory response 0.407797915924736 0.825384309082817 0.999502784407319 0.125 1.3 1 3 cochlear outer hair cell degeneration 0.407797915924736 0.825384309082817 0.999502784407319 0.125 1.3 1 3 decreased eosinophil cell number 0.419168372339136 0.845645844439255 0.999502784407319 0.125 1.3 1 3 oligodactyly 0.44610260446705 0.854915430363473 0.999502784407319 0.125 1.3 1 3 abnormal phalanx morphology 0.44610260446705 0.854915430363473 0.999502784407319 0.125 1.3 1 3 head bobbing 0.462697265757469 0.880274912865549 0.999502784407319 0.125 1.3 1 3 abnormal skeleton development 0.412977497843251 0.835188232426901 0.98716324385908 0.123456790123457 1.3 1 3 impaired natural killer cell mediated cytotoxicity 0.450625382316301 0.858950680851953 0.98196764783877 0.12280701754386 1.3 1 3 abnormal circulating amino acid level 0.450625382316301 0.858950680851953 0.98196764783877 0.12280701754386 1.3 1 3 increased tumor growth/size 0.485010540309221 0.912259900959687 0.975124667714458 0.121951219512195 1.3 1 3 palatal shelves fail to meet at midline 0.485010540309221 0.912259900959687 0.975124667714458 0.121951219512195 1.3 1 3 abnormal T cell activation 0.440714946434184 0.853929474613872 0.972489195639554 0.121621621621622 1.3 1 3 impaired swimming 0.454193842732752 0.865421052315374 0.969214821243461 0.121212121212121 1.3 1 3 deafness 0.421191242882331 0.849382421296959 0.969214821243461 0.121212121212121 1.3 1 3 small ovary 0.432152152082364 0.853929474613872 0.966552143163122 0.120879120879121 1.3 1 3 abnormal spermiogenesis 0.469323123921897 0.891734259239537 0.965037171151894 0.120689655172414 1.3 1 3 abnormal optic nerve morphology 0.506987888813477 0.920132028117216 0.951907413721256 0.119047619047619 1.3 1 3 increased hemoglobin content 0.487860371531864 0.91727337428988 0.948680608928981 0.11864406779661 1.3 1 3 circling 0.474945758394673 0.897741317634308 0.940708502971594 0.117647058823529 1.3 1 3 retinal degeneration 0.505300613847409 0.920132028117216 0.916210885706709 0.114583333333333 1.3 1 3 increased circulating HDL cholesterol level 0.505150064726274 0.920132028117216 0.913831117172406 0.114285714285714 1.3 1 3 abnormal action potential 0.52282372221628 0.944804946613147 0.913831117172406 0.114285714285714 1.3 1 3 increased eosinophil cell number 0.542175421340653 0.974599446258516 0.902776708496933 0.112903225806452 1.3 1 3 abnormal locomotor activation 0.56482255680575 0.985962182494248 0.878683766511929 0.10989010989011 1.3 1 3 abnormal excitatory postsynaptic potential 0.568204708709393 0.991518213198607 0.877612200943012 0.109756097560976 1.3 1 3 decreased caudal vertebrae number 0.577013252840266 1 0.874564936356404 0.109375 1.3 1 3 abnormal sleep pattern 0.590608137316972 1 0.869132856006364 0.108695652173913 1.3 1 3 abnormal enzyme/coenzyme level 0.636064804548489 1 0.827174718130195 0.103448275862069 1.3 1 3 abnormal inhibitory postsynaptic currents 0.642563967531141 1 0.823119940100145 0.102941176470588 1.3 1 3 short femur 0.65482476776998 1 0.81777500542417 0.102272727272727 1.3 1 3 increased sarcoma incidence 0.64785071196675 1 0.815920640332505 0.102040816326531 1.3 1 3 abnormal neuron morphology 0.673253070403605 1 0.807679017702884 0.101010101010101 1.3 1 3 abnormal social investigation 0.677132178372526 1 0.799602227525855 0.1 1.3 1 3 decreased respiratory quotient 0.665763259907598 1 0.799602227525855 0.1 1.3 1 3 increased lung adenocarcinoma incidence 0.683068792219255 1 0.783923752476329 0.0980392156862745 1.3 1 3 decreased birth weight 0.742014128479732 1 0.757517899761337 0.0947368421052632 1.3 1 3 increased thermal nociceptive threshold 0.806221924798241 1 0.702947013209543 0.0879120879120879 1.3 1 3 cochlear ganglion degeneration 0.786940805165963 1 0.689312265108496 0.0862068965517241 1.3 1 3 decreased mast cell histamine storage 0.0021012421251205 0.0245391539259964 2.43117224638414 1 10.1 10 1 abnormal pulmonary trunk morphology 0.0021012421251205 0.0245391539259964 2.43117224638414 1 10.1 10 1 decreased sensitivity to skin irradiation 0.0021012421251205 0.0245391539259964 2.43117224638414 1 10.1 10 1 improved righting response 0.0021012421251205 0.0245391539259964 2.43117224638414 1 10.1 10 1 abnormal mismatch repair 0.0021012421251205 0.0245391539259964 2.43117224638414 1 10.1 10 1 decreased leukotriene level 0.0021012421251205 0.0245391539259964 2.43117224638414 1 10.1 10 1 prolonged ST segment 0.0021012421251205 0.0245391539259964 2.43117224638414 1 10.1 10 1 decreased platelet alpha-granule number 0.0021012421251205 0.0245391539259964 2.43117224638414 1 10.1 10 1 failure of atrioventricular cushion closure 0.000178339921825633 0.00362139229013276 2.43117224638414 1 10.1 10 1 thymus cortex atrophy 0.000612178268240242 0.00976149642466412 2.43117224638414 1 10.1 10 1 abnormal ear pigmentation 0.00106306725344279 0.0151107416739369 2.12727571558612 0.875 10.1 10 1 altered response to CNS ischemic injury 0.00106306725344279 0.0151107416739369 2.12727571558612 0.875 10.1 10 1 tau protein deposits 0.00106306725344279 0.0151107416739369 2.12727571558612 0.875 10.1 10 1 abnormal kidney epithelium morphology 0.00106306725344279 0.0151107416739369 2.12727571558612 0.875 10.1 10 1 abnormal tumor incidence 0.00321520834672789 0.0334637270396888 2.08386192547212 0.857142857142857 10.1 10 1 decreased tidal volume 0.00321520834672789 0.0334637270396888 2.08386192547212 0.857142857142857 10.1 10 1 absent popliteal lymph nodes 0.00321520834672789 0.0334637270396888 2.08386192547212 0.857142857142857 10.1 10 1 heart hemorrhage 0.00321520834672789 0.0334637270396888 2.08386192547212 0.857142857142857 10.1 10 1 abnormal conotruncal ridge morphology 0.00321520834672789 0.0334637270396888 2.08386192547212 0.857142857142857 10.1 10 1 impaired embryo implantation 0.000157412821884348 0.00334670422595996 2.02597687198678 0.833333333333333 10.1 10 1 ectopic digits 0.00954656140952179 0.0706554586523516 2.02597687198678 0.833333333333333 10.1 10 1 jumpy 0.00954656140952179 0.0706554586523516 2.02597687198678 0.833333333333333 10.1 10 1 abnormal parental behavior 0.00954656140952179 0.0706554586523516 2.02597687198678 0.833333333333333 10.1 10 1 enlarged pancreas 0.00954656140952179 0.0706554586523516 2.02597687198678 0.833333333333333 10.1 10 1 abnormal leukocyte tethering or rolling 0.00954656140952179 0.0706554586523516 2.02597687198678 0.833333333333333 10.1 10 1 impaired granulocyte bactericidal activity 0.00954656140952179 0.0706554586523516 2.02597687198678 0.833333333333333 10.1 10 1 abnormal olfactory bulb layer morphology 0.00954656140952179 0.0706554586523516 2.02597687198678 0.833333333333333 10.1 10 1 myocardium hypoplasia 0.00954656140952179 0.0706554586523516 2.02597687198678 0.833333333333333 10.1 10 1 abnormal spinal cord ventral horn morphology 0.000453697144141093 0.00759980906431629 1.98914092885975 0.818181818181818 10.1 10 1 decreased mast cell number 2.37257905885447e-05 0.000737723801112562 1.97532745018711 0.8125 10.1 10 1 abnormal primordial germ cell migration 0.0012858665023411 0.0173095447453598 1.94493779710731 0.8 10.1 10 1 peritoneal inflammation 0.0012858665023411 0.0173095447453598 1.94493779710731 0.8 10.1 10 1 abnormal gas homeostasis 0.0012858665023411 0.0173095447453598 1.94493779710731 0.8 10.1 10 1 abnormal hippocampus neuron morphology 0.0012858665023411 0.0173095447453598 1.94493779710731 0.8 10.1 10 1 decreased macrophage apoptosis 0.0012858665023411 0.0173095447453598 1.94493779710731 0.8 10.1 10 1 heart hyperplasia 0.00357106420387918 0.035746568238026 1.89091174718767 0.777777777777778 10.1 10 1 decreased level of surface class I molecules 0.00357106420387918 0.035746568238026 1.89091174718767 0.777777777777778 10.1 10 1 increased neuronal precursor cell number 0.00357106420387918 0.035746568238026 1.89091174718767 0.777777777777778 10.1 10 1 abnormal gallbladder physiology 0.00357106420387918 0.035746568238026 1.89091174718767 0.777777777777778 10.1 10 1 liver hyperplasia 0.00357106420387918 0.035746568238026 1.89091174718767 0.777777777777778 10.1 10 1 abnormal leukopoiesis 0.00357106420387918 0.035746568238026 1.89091174718767 0.777777777777778 10.1 10 1 retropulsion 0.00357106420387918 0.035746568238026 1.89091174718767 0.777777777777778 10.1 10 1 abnormal T cell proliferation 3.69079888460592e-08 2.82488068475607e-06 1.88219786816837 0.774193548387097 10.1 10 1 embryonic lethality before implantation, incomplete penetrance 4.1461739133282e-06 0.000170472853047998 1.87863309947865 0.772727272727273 10.1 10 1 enhanced behavioral response to cocaine 7.37311716446789e-05 0.00183406289466139 1.85913171782317 0.764705882352941 10.1 10 1 abnormal thymus involution 0.00134255011091133 0.0174391300307673 1.82337918478811 0.75 10.1 10 1 increased papilloma incidence 0.00134255011091133 0.0174391300307673 1.82337918478811 0.75 10.1 10 1 abnormal vascular endothelial cell development 0.00134255011091133 0.0174391300307673 1.82337918478811 0.75 10.1 10 1 abnormal fatty acid level 0.00134255011091133 0.0174391300307673 1.82337918478811 0.75 10.1 10 1 decreased mammary gland epithelial cell proliferation 0.00134255011091133 0.0174391300307673 1.82337918478811 0.75 10.1 10 1 disorganized yolk sac vascular plexus 0.000195430343586155 0.00381280768369066 1.82337918478811 0.75 10.1 10 1 abnormal epicardium morphology 0.000195430343586155 0.00381280768369066 1.82337918478811 0.75 10.1 10 1 small pancreas 0.000195430343586155 0.00381280768369066 1.82337918478811 0.75 10.1 10 1 absent mammary gland 0.00967163162658321 0.0706554586523516 1.82337918478811 0.75 10.1 10 1 abnormal erythrocyte cell number 0.00967163162658321 0.0706554586523516 1.82337918478811 0.75 10.1 10 1 abnormal urination 0.00967163162658321 0.0706554586523516 1.82337918478811 0.75 10.1 10 1 decreased aerobic running capacity 0.00967163162658321 0.0706554586523516 1.82337918478811 0.75 10.1 10 1 abnormal cellular cholesterol metabolism 0.00967163162658321 0.0706554586523516 1.82337918478811 0.75 10.1 10 1 increased cardiac output 0.00967163162658321 0.0706554586523516 1.82337918478811 0.75 10.1 10 1 absent interparietal bone 0.00967163162658321 0.0706554586523516 1.82337918478811 0.75 10.1 10 1 abnormal NK cell morphology 0.00967163162658321 0.0706554586523516 1.82337918478811 0.75 10.1 10 1 abnormal choroid pigmentation 0.00967163162658321 0.0706554586523516 1.82337918478811 0.75 10.1 10 1 abnormal somite size 0.00967163162658321 0.0706554586523516 1.82337918478811 0.75 10.1 10 1 abnormal olfactory bulb mitral cell layer morphology 0.00967163162658321 0.0706554586523516 1.82337918478811 0.75 10.1 10 1 abnormal cerebellum deep nucleus morphology 0.00967163162658321 0.0706554586523516 1.82337918478811 0.75 10.1 10 1 increased caudal vertebrae number 0.00967163162658321 0.0706554586523516 1.82337918478811 0.75 10.1 10 1 abnormal heart echocardiography feature 0.00967163162658321 0.0706554586523516 1.82337918478811 0.75 10.1 10 1 decreased vascular endothelial cell proliferation 0.00967163162658321 0.0706554586523516 1.82337918478811 0.75 10.1 10 1 abnormal lymph node B cell domain morphology 0.000508809408151126 0.00835421387970908 1.78285964734837 0.733333333333333 10.1 10 1 liver vascular congestion 0.000508809408151126 0.00835421387970908 1.78285964734837 0.733333333333333 10.1 10 1 abnormal stomach epithelium morphology 0.00350498479087446 0.035596099204667 1.76812527009756 0.727272727272727 10.1 10 1 abnormal crista ampullaris neuroepithelium morphology 0.00350498479087446 0.035596099204667 1.76812527009756 0.727272727272727 10.1 10 1 decreased core body temperature 0.00350498479087446 0.035596099204667 1.76812527009756 0.727272727272727 10.1 10 1 abnormal megakaryocyte differentiation 0.000194238727545675 0.00381280768369066 1.75584662238855 0.722222222222222 10.1 10 1 abnormal neutrophil morphology 0.000194238727545675 0.00381280768369066 1.75584662238855 0.722222222222222 10.1 10 1 decreased lactate dehydrogenase level 0.000194238727545675 0.00381280768369066 1.75584662238855 0.722222222222222 10.1 10 1 abnormal macrophage chemotaxis 0.000194238727545675 0.00381280768369066 1.75584662238855 0.722222222222222 10.1 10 1 abnormal cytotoxic T cell physiology 1.77444005934779e-08 1.47130654920921e-06 1.7365516045601 0.714285714285714 10.1 10 1 shortened head 4.51043290750308e-06 0.000176688218226991 1.7365516045601 0.714285714285714 10.1 10 1 lymphoid hyperplasia 4.51043290750308e-06 0.000176688218226991 1.7365516045601 0.714285714285714 10.1 10 1 increased hemangioma incidence 0.00129778094271743 0.0173095447453598 1.7365516045601 0.714285714285714 10.1 10 1 abnormal iris pigmentation 0.00129778094271743 0.0173095447453598 1.7365516045601 0.714285714285714 10.1 10 1 pulmonary alveolar hemorrhage 0.00129778094271743 0.0173095447453598 1.7365516045601 0.714285714285714 10.1 10 1 testis degeneration 0.00129778094271743 0.0173095447453598 1.7365516045601 0.714285714285714 10.1 10 1 cochlear degeneration 0.0253749440665065 0.14259747171786 1.7365516045601 0.714285714285714 10.1 10 1 abnormal circulating free fatty acids level 0.0253749440665065 0.14259747171786 1.7365516045601 0.714285714285714 10.1 10 1 decreased mortality induced by ionizing radiation 0.0253749440665065 0.14259747171786 1.7365516045601 0.714285714285714 10.1 10 1 absent deltoid tuberosity 0.0253749440665065 0.14259747171786 1.7365516045601 0.714285714285714 10.1 10 1 abnormal body temperature 0.0253749440665065 0.14259747171786 1.7365516045601 0.714285714285714 10.1 10 1 increased tumor latency 0.0253749440665065 0.14259747171786 1.7365516045601 0.714285714285714 10.1 10 1 decreased DN2 thymocyte number 0.0253749440665065 0.14259747171786 1.7365516045601 0.714285714285714 10.1 10 1 decreased DN4 thymocyte number 0.0253749440665065 0.14259747171786 1.7365516045601 0.714285714285714 10.1 10 1 arteritis 0.0253749440665065 0.14259747171786 1.7365516045601 0.714285714285714 10.1 10 1 decreased brain cholesterol level 0.0253749440665065 0.14259747171786 1.7365516045601 0.714285714285714 10.1 10 1 altered tumor pathology 0.0253749440665065 0.14259747171786 1.7365516045601 0.714285714285714 10.1 10 1 dilated pulmonary alveolar ducts 0.0253749440665065 0.14259747171786 1.7365516045601 0.714285714285714 10.1 10 1 parturition failure 0.0253749440665065 0.14259747171786 1.7365516045601 0.714285714285714 10.1 10 1 ductus venosus stenosis 0.0253749440665065 0.14259747171786 1.7365516045601 0.714285714285714 10.1 10 1 abnormal melanosome morphology 0.000487508356245695 0.0081115520813456 1.71612158568292 0.705882352941177 10.1 10 1 abnormal immune cell physiology 0.0089031921741347 0.0680389878130877 1.7018205724689 0.7 10.1 10 1 acrania 0.0089031921741347 0.0680389878130877 1.7018205724689 0.7 10.1 10 1 lymphedema 0.0089031921741347 0.0680389878130877 1.7018205724689 0.7 10.1 10 1 osteosclerosis 0.0089031921741347 0.0680389878130877 1.7018205724689 0.7 10.1 10 1 absent inguinal lymph nodes 0.0089031921741347 0.0680389878130877 1.7018205724689 0.7 10.1 10 1 absent axillary lymph nodes 0.0089031921741347 0.0680389878130877 1.7018205724689 0.7 10.1 10 1 abnormal inferior vena cava valve morphology 0.0089031921741347 0.0680389878130877 1.7018205724689 0.7 10.1 10 1 abnormal xiphoid process morphology 2.72424763698514e-05 0.000821401939030369 1.68311924749671 0.692307692307692 10.1 10 1 absent hypoglossal nerve 0.00323238487766256 0.0335677275831593 1.68311924749671 0.692307692307692 10.1 10 1 abnormal vascular branching morphogenesis 0.000171084587154273 0.00350265769996916 1.65761744071646 0.681818181818182 10.1 10 1 abnormal ovulation 2.52074663176211e-05 0.000778926366025868 1.6497240243321 0.678571428571429 10.1 10 1 decreased susceptibility to bacterial infection induced morbidity/mortality 9.7514023396688e-06 0.00034164244112572 1.64692313464732 0.67741935483871 10.1 10 1 increased brain weight 5.94013275309009e-05 0.0015312000231411 1.62078149758943 0.666666666666667 10.1 10 1 hemolytic anemia 0.000154755895137843 0.00330433724596896 1.62078149758943 0.666666666666667 10.1 10 1 abnormal cardiac muscle contractility 0.000154755895137843 0.00330433724596896 1.62078149758943 0.666666666666667 10.1 10 1 abnormal cellular extravasation 0.000154755895137843 0.00330433724596896 1.62078149758943 0.666666666666667 10.1 10 1 abnormal tumor vascularization 0.000405911718846759 0.00698758062720633 1.62078149758943 0.666666666666667 10.1 10 1 absent allantois 0.00107404761364574 0.0151800763576351 1.62078149758943 0.666666666666667 10.1 10 1 primary atelectasis 0.00107404761364574 0.0151800763576351 1.62078149758943 0.666666666666667 10.1 10 1 abnormal mating frequency 0.00782985415080075 0.062325639040374 1.62078149758943 0.666666666666667 10.1 10 1 myocarditis 0.00782985415080075 0.062325639040374 1.62078149758943 0.666666666666667 10.1 10 1 abnormal embryonic growth/weight/body size 0.00782985415080075 0.062325639040374 1.62078149758943 0.666666666666667 10.1 10 1 abnormal respiratory function 0.00782985415080075 0.062325639040374 1.62078149758943 0.666666666666667 10.1 10 1 pale placenta 0.00782985415080075 0.062325639040374 1.62078149758943 0.666666666666667 10.1 10 1 abnormal palatine bone morphology 0.00782985415080075 0.062325639040374 1.62078149758943 0.666666666666667 10.1 10 1 abnormal head movements 0.0218727664719912 0.130947067627144 1.62078149758943 0.666666666666667 10.1 10 1 abnormal kindling response 0.0218727664719912 0.130947067627144 1.62078149758943 0.666666666666667 10.1 10 1 genetic imprinting 0.0218727664719912 0.130947067627144 1.62078149758943 0.666666666666667 10.1 10 1 enlarged otoliths 0.0218727664719912 0.130947067627144 1.62078149758943 0.666666666666667 10.1 10 1 abnormal artery development 0.0218727664719912 0.130947067627144 1.62078149758943 0.666666666666667 10.1 10 1 premature bone ossification 0.0218727664719912 0.130947067627144 1.62078149758943 0.666666666666667 10.1 10 1 abnormal thymus physiology 0.0218727664719912 0.130947067627144 1.62078149758943 0.666666666666667 10.1 10 1 small scapula 0.0218727664719912 0.130947067627144 1.62078149758943 0.666666666666667 10.1 10 1 abnormal inguinal fat pad morphology 0.0218727664719912 0.130947067627144 1.62078149758943 0.666666666666667 10.1 10 1 decreased susceptibility to atherosclerosis 0.0218727664719912 0.130947067627144 1.62078149758943 0.666666666666667 10.1 10 1 absent cervical lymph nodes 0.0218727664719912 0.130947067627144 1.62078149758943 0.666666666666667 10.1 10 1 axonal spheroids 0.0218727664719912 0.130947067627144 1.62078149758943 0.666666666666667 10.1 10 1 decreased susceptibility to parasitic infection induced morbidity/mortality 0.0218727664719912 0.130947067627144 1.62078149758943 0.666666666666667 10.1 10 1 decreased effector memory CD4-positive, alpha-beta T cell number 0.0218727664719912 0.130947067627144 1.62078149758943 0.666666666666667 10.1 10 1 cerebellum atrophy 0.0218727664719912 0.130947067627144 1.62078149758943 0.666666666666667 10.1 10 1 decreased platelet dense granule number 0.0218727664719912 0.130947067627144 1.62078149758943 0.666666666666667 10.1 10 1 impaired macrophage chemotaxis 1.34823368163108e-06 6.32779487369304e-05 1.62078149758943 0.666666666666667 10.1 10 1 absent chorion 0.00287572401185003 0.0310341148784249 1.62078149758943 0.666666666666667 10.1 10 1 abnormal secondary palate development 0.00287572401185003 0.0310341148784249 1.62078149758943 0.666666666666667 10.1 10 1 lordosis 5.30834931549706e-05 0.00141984074433322 1.5928369890103 0.655172413793103 10.1 10 1 abnormal embryonic erythropoiesis 5.30834931549706e-05 0.00141984074433322 1.5928369890103 0.655172413793103 10.1 10 1 ventricular hypoplasia 0.000137690372687708 0.00304448712942822 1.58961262263578 0.653846153846154 10.1 10 1 spleen hyperplasia 9.0814358511742e-11 1.30338938963727e-08 1.58836586763764 0.653333333333333 10.1 10 1 dilated heart 0.000359148204221106 0.00626934145964914 1.58554711720705 0.652173913043478 10.1 10 1 abnormal vasculogenesis 1.090265619312e-06 5.37036777829424e-05 1.58308890462223 0.651162790697674 10.1 10 1 abnormal pericardium morphology 0.000943440869192479 0.0138047597771547 1.58026196014969 0.65 10.1 10 1 decreased myocardial infarction size 0.000943440869192479 0.0138047597771547 1.58026196014969 0.65 10.1 10 1 abnormal spleen red pulp morphology 1.82295676195487e-05 0.000600609926538112 1.57311145354268 0.647058823529412 10.1 10 1 abnormal dorsal-ventral axis patterning 0.00250125750576607 0.027530433830058 1.57311145354268 0.647058823529412 10.1 10 1 pancytopenia 0.00250125750576607 0.027530433830058 1.57311145354268 0.647058823529412 10.1 10 1 abnormal kidney blood vessel morphology 0.00671467196056379 0.0571034068441108 1.56289644410409 0.642857142857143 10.1 10 1 absent visceral yolk sac blood islands 0.00671467196056379 0.0571034068441108 1.56289644410409 0.642857142857143 10.1 10 1 abnormal antigen presentation 0.00671467196056379 0.0571034068441108 1.56289644410409 0.642857142857143 10.1 10 1 decreased coping response 0.00671467196056379 0.0571034068441108 1.56289644410409 0.642857142857143 10.1 10 1 vascular smooth muscle hypoplasia 0.00671467196056379 0.0571034068441108 1.56289644410409 0.642857142857143 10.1 10 1 increased B-1 B cell number 0.00671467196056379 0.0571034068441108 1.56289644410409 0.642857142857143 10.1 10 1 abnormal viscerocranium morphology 0.00671467196056379 0.0571034068441108 1.56289644410409 0.642857142857143 10.1 10 1 spina bifida occulta 0.00671467196056379 0.0571034068441108 1.56289644410409 0.642857142857143 10.1 10 1 increased lung compliance 0.00671467196056379 0.0571034068441108 1.56289644410409 0.642857142857143 10.1 10 1 decreased response to antigen 0.00671467196056379 0.0571034068441108 1.56289644410409 0.642857142857143 10.1 10 1 decreased B-1 B cell number 6.27259268888618e-06 0.000231156656497843 1.55844374768214 0.641025641025641 10.1 10 1 abnormal interventricular septum morphology 3.36864942497366e-07 1.90443532832318e-05 1.55595023768585 0.64 10.1 10 1 abnormal lysosome physiology 0.000816859199308617 0.0123898613309767 1.54710961133536 0.636363636363636 10.1 10 1 decreased circulating estradiol level 0.000816859199308617 0.0123898613309767 1.54710961133536 0.636363636363636 10.1 10 1 abnormal thrombopoiesis 0.0183500550948401 0.115121720172546 1.54710961133536 0.636363636363636 10.1 10 1 decreased atrioventricular cushion size 0.0183500550948401 0.115121720172546 1.54710961133536 0.636363636363636 10.1 10 1 abnormal eye distance/ position 0.0183500550948401 0.115121720172546 1.54710961133536 0.636363636363636 10.1 10 1 patent ductus arteriosus 0.0183500550948401 0.115121720172546 1.54710961133536 0.636363636363636 10.1 10 1 abnormal radial glial cell morphology 0.0183500550948401 0.115121720172546 1.54710961133536 0.636363636363636 10.1 10 1 abnormal dorsal-ventral polarity of the somites 0.0183500550948401 0.115121720172546 1.54710961133536 0.636363636363636 10.1 10 1 abnormal fat pad morphology 0.000105178979504014 0.0024451655281891 1.53974242270996 0.633333333333333 10.1 10 1 decreased B cell proliferation 3.17779875591745e-10 4.05373046427931e-08 1.53871661163553 0.632911392405063 10.1 10 1 increased T cell derived lymphoma incidence 7.47322318493583e-07 3.87284222344331e-05 1.53808856403895 0.63265306122449 10.1 10 1 kyphoscoliosis 0.0021430208594364 0.0247929940616736 1.53547720824262 0.631578947368421 10.1 10 1 decreased tumor incidence 0.0021430208594364 0.0247929940616736 1.53547720824262 0.631578947368421 10.1 10 1 increased left ventricle weight 0.0021430208594364 0.0247929940616736 1.53547720824262 0.631578947368421 10.1 10 1 decreased liver regeneration 0.0021430208594364 0.0247929940616736 1.53547720824262 0.631578947368421 10.1 10 1 abnormal lymphocyte physiology 1.88840692007898e-06 8.69891150684528e-05 1.53269554663348 0.630434782608696 10.1 10 1 abnormal atrioventricular cushion morphology 0.000270781749454283 0.00498940445753726 1.53073808105668 0.62962962962963 10.1 10 1 abnormal liver development 3.55561398492612e-05 0.00102249592919118 1.52816541201289 0.628571428571429 10.1 10 1 impaired muscle relaxation 0.00567152511460996 0.0502956104192238 1.51948265399009 0.625 10.1 10 1 abnormal pulmonary elastic fiber morphology 0.00567152511460996 0.0502956104192238 1.51948265399009 0.625 10.1 10 1 sepsis 0.00567152511460996 0.0502956104192238 1.51948265399009 0.625 10.1 10 1 decreased circulating triiodothyronine level 0.00567152511460996 0.0502956104192238 1.51948265399009 0.625 10.1 10 1 decreased creatinine clearance 0.00567152511460996 0.0502956104192238 1.51948265399009 0.625 10.1 10 1 failure of vascular branching 0.0515471314663788 0.232710507300576 1.51948265399009 0.625 10.1 10 1 dermal cysts 0.0515471314663788 0.232710507300576 1.51948265399009 0.625 10.1 10 1 dry eyes 0.0515471314663788 0.232710507300576 1.51948265399009 0.625 10.1 10 1 head spot 0.0515471314663788 0.232710507300576 1.51948265399009 0.625 10.1 10 1 hypospadia 0.0515471314663788 0.232710507300576 1.51948265399009 0.625 10.1 10 1 abnormal umbilical artery morphology 0.0515471314663788 0.232710507300576 1.51948265399009 0.625 10.1 10 1 abnormal perineum morphology 0.0515471314663788 0.232710507300576 1.51948265399009 0.625 10.1 10 1 abnormal platelet shape 0.0515471314663788 0.232710507300576 1.51948265399009 0.625 10.1 10 1 pulmonary interstitial fibrosis 0.0515471314663788 0.232710507300576 1.51948265399009 0.625 10.1 10 1 binucleate 0.0515471314663788 0.232710507300576 1.51948265399009 0.625 10.1 10 1 abnormal skin development 0.0515471314663788 0.232710507300576 1.51948265399009 0.625 10.1 10 1 abnormal extraembryonic tissue physiology 0.0515471314663788 0.232710507300576 1.51948265399009 0.625 10.1 10 1 non-pigmented tail tip 0.0515471314663788 0.232710507300576 1.51948265399009 0.625 10.1 10 1 abnormal ilium morphology 0.0515471314663788 0.232710507300576 1.51948265399009 0.625 10.1 10 1 abnormal mast cell differentiation 0.0515471314663788 0.232710507300576 1.51948265399009 0.625 10.1 10 1 choroidal neovascularization 0.0515471314663788 0.232710507300576 1.51948265399009 0.625 10.1 10 1 increased pulmonary ventilation 0.0515471314663788 0.232710507300576 1.51948265399009 0.625 10.1 10 1 abnormal epidermal lamellar body morphology 0.0515471314663788 0.232710507300576 1.51948265399009 0.625 10.1 10 1 abnormal sphingomyelin level 0.0515471314663788 0.232710507300576 1.51948265399009 0.625 10.1 10 1 abnormal circulating serum amyloid protein level 0.0515471314663788 0.232710507300576 1.51948265399009 0.625 10.1 10 1 heart right ventricle hypoplasia 0.0515471314663788 0.232710507300576 1.51948265399009 0.625 10.1 10 1 abnormal hepatic vein morphology 0.0515471314663788 0.232710507300576 1.51948265399009 0.625 10.1 10 1 myocardial trabeculae hypoplasia 0.0515471314663788 0.232710507300576 1.51948265399009 0.625 10.1 10 1 delayed suture closure 0.0515471314663788 0.232710507300576 1.51948265399009 0.625 10.1 10 1 decreased lung compliance 0.0515471314663788 0.232710507300576 1.51948265399009 0.625 10.1 10 1 increased aorta wall thickness 0.0515471314663788 0.232710507300576 1.51948265399009 0.625 10.1 10 1 abnormal macrophage activation involved in immune response 0.0515471314663788 0.232710507300576 1.51948265399009 0.625 10.1 10 1 absent Reichert's membrane 0.0515471314663788 0.232710507300576 1.51948265399009 0.625 10.1 10 1 increased cornea thickness 0.0515471314663788 0.232710507300576 1.51948265399009 0.625 10.1 10 1 absent hypoglossal canal 0.0515471314663788 0.232710507300576 1.51948265399009 0.625 10.1 10 1 increased mammary gland apoptosis 0.0515471314663788 0.232710507300576 1.51948265399009 0.625 10.1 10 1 increased mortality induced by gamma-irradiation 0.000232005016085441 0.0043720642235798 1.50900346327292 0.620689655172414 10.1 10 1 abnormal response to infection 1.31376950560657e-09 1.48545529327106e-07 1.50794227940282 0.620253164556962 10.1 10 1 abnormal erythropoiesis 3.18783427703415e-12 6.34379021129795e-10 1.50501139061875 0.619047619047619 10.1 10 1 abnormal eye pigmentation 0.00181692573850427 0.022156544258372 1.50501139061875 0.619047619047619 10.1 10 1 left pulmonary isomerism 0.00181692573850427 0.022156544258372 1.50501139061875 0.619047619047619 10.1 10 1 abnormal erythrocyte physiology 0.00181692573850427 0.022156544258372 1.50501139061875 0.619047619047619 10.1 10 1 decreased regulatory T cell number 7.77468525237611e-05 0.00192433130002842 1.50160638747256 0.617647058823529 10.1 10 1 abnormal leukocyte adhesion 2.62627708684951e-05 0.000801578436016951 1.49610599777486 0.615384615384615 10.1 10 1 abnormal placenta vasculature 1.21939973665441e-06 5.94756244103498e-05 1.49610599777486 0.615384615384615 10.1 10 1 absent teeth 0.0151858049878219 0.10140856350928 1.49610599777486 0.615384615384615 10.1 10 1 absent common myeloid progenitor cells 0.0151858049878219 0.10140856350928 1.49610599777486 0.615384615384615 10.1 10 1 abnormal mast cell morphology 0.0151858049878219 0.10140856350928 1.49610599777486 0.615384615384615 10.1 10 1 lymphoid hypoplasia 0.0151858049878219 0.10140856350928 1.49610599777486 0.615384615384615 10.1 10 1 abnormal otolith morphology 0.0151858049878219 0.10140856350928 1.49610599777486 0.615384615384615 10.1 10 1 abnormal afterhyperpolarization 0.0151858049878219 0.10140856350928 1.49610599777486 0.615384615384615 10.1 10 1 extramedullary hematopoiesis 5.89556260732159e-12 1.08579300159677e-09 1.49081316995254 0.613207547169811 10.1 10 1 inner cell mass degeneration 0.000197499608156733 0.00382319280381225 1.49007331229996 0.612903225806452 10.1 10 1 abnormal CD8-positive, alpha beta T cell morphology 0.000197499608156733 0.00382319280381225 1.49007331229996 0.612903225806452 10.1 10 1 pallor 1.35714732287041e-18 6.13800721025482e-16 1.48648817350345 0.611428571428571 10.1 10 1 abnormal lysosome morphology 6.62632698358803e-05 0.00169056290991541 1.48571637279031 0.611111111111111 10.1 10 1 abnormal mitral valve morphology 0.00474401590766947 0.0437875308732015 1.48571637279031 0.611111111111111 10.1 10 1 abnormal phrenic nerve morphology 0.00474401590766947 0.0437875308732015 1.48571637279031 0.611111111111111 10.1 10 1 abnormal thymus medulla morphology 0.00474401590766947 0.0437875308732015 1.48571637279031 0.611111111111111 10.1 10 1 abnormal hypoglossal nerve topology 0.00474401590766947 0.0437875308732015 1.48571637279031 0.611111111111111 10.1 10 1 increased B cell proliferation 3.59649908751701e-07 2.0104025798199e-05 1.48342713338693 0.610169491525424 10.1 10 1 abnormal allantois morphology 7.62014864026138e-06 0.00027273553586547 1.47984397605991 0.608695652173913 10.1 10 1 increased granulocyte number 1.48573837388759e-08 1.31991935894477e-06 1.4784155552336 0.608108108108108 10.1 10 1 increased bone marrow cell number 5.622122493491e-05 0.0014877691172935 1.47149899123251 0.605263157894737 10.1 10 1 decreased hair follicle number 5.622122493491e-05 0.0014877691172935 1.47149899123251 0.605263157894737 10.1 10 1 abnormal osteoclast morphology 6.48190072277718e-06 0.000236256313122533 1.46883323219042 0.604166666666667 10.1 10 1 increased B cell derived lymphoma incidence 5.4965282603224e-06 0.000207160818902303 1.45870334783048 0.6 10.1 10 1 decreased acute inflammation 0.00127928740993837 0.0173095447453598 1.45870334783048 0.6 10.1 10 1 abnormal circulating enzyme level 0.0039423908448023 0.0383823766201398 1.45870334783048 0.6 10.1 10 1 abnormal induced retinal neovascularization 0.0039423908448023 0.0383823766201398 1.45870334783048 0.6 10.1 10 1 abnormal neuron proliferation 0.0039423908448023 0.0383823766201398 1.45870334783048 0.6 10.1 10 1 increased cranium width 0.0413271279187761 0.201571040584227 1.45870334783048 0.6 10.1 10 1 decreased incidence of induced tumors 0.0413271279187761 0.201571040584227 1.45870334783048 0.6 10.1 10 1 abnormal airway responsiveness 0.0413271279187761 0.201571040584227 1.45870334783048 0.6 10.1 10 1 impaired basement membrane formation 0.0413271279187761 0.201571040584227 1.45870334783048 0.6 10.1 10 1 abnormal submandibular gland morphology 0.0413271279187761 0.201571040584227 1.45870334783048 0.6 10.1 10 1 increased platelet aggregation 0.0413271279187761 0.201571040584227 1.45870334783048 0.6 10.1 10 1 decreased transitional stage T2 B cell number 0.0413271279187761 0.201571040584227 1.45870334783048 0.6 10.1 10 1 abnormal cerebellar granule cell migration 0.0413271279187761 0.201571040584227 1.45870334783048 0.6 10.1 10 1 acanthocytosis 0.0413271279187761 0.201571040584227 1.45870334783048 0.6 10.1 10 1 abnormal heart and great artery attachment 0.0413271279187761 0.201571040584227 1.45870334783048 0.6 10.1 10 1 abnormal left subclavian artery morphology 0.0413271279187761 0.201571040584227 1.45870334783048 0.6 10.1 10 1 thin ventricle myocardium compact layer 0.0413271279187761 0.201571040584227 1.45870334783048 0.6 10.1 10 1 abnormal adaptive thermogenesis 0.0413271279187761 0.201571040584227 1.45870334783048 0.6 10.1 10 1 decreased macrophage cytokine production 0.0413271279187761 0.201571040584227 1.45870334783048 0.6 10.1 10 1 thick pulmonary interalveolar septum 0.000141032921535509 0.00305060341147461 1.45870334783048 0.6 10.1 10 1 increased circulating serum albumin level 0.000141032921535509 0.00305060341147461 1.45870334783048 0.6 10.1 10 1 abnormal kidney development 6.46787177781233e-07 3.38712232574909e-05 1.45870334783048 0.6 10.1 10 1 abnormal response to new environment 0.000422244070957582 0.0072182523172675 1.45870334783048 0.6 10.1 10 1 decreased hepatocyte number 0.0124730938836344 0.0873343166507914 1.45870334783048 0.6 10.1 10 1 vagina atresia 0.0124730938836344 0.0873343166507914 1.45870334783048 0.6 10.1 10 1 abnormal dendritic cell morphology 0.0124730938836344 0.0873343166507914 1.45870334783048 0.6 10.1 10 1 abnormal leukocyte migration 4.64821550076725e-06 0.000180663063408727 1.44935268534439 0.596153846153846 10.1 10 1 increased circulating phosphate level 0.000118506710605607 0.00271691652194883 1.44556187622841 0.594594594594595 10.1 10 1 abnormal embryonic hematopoiesis 0.000353552017900586 0.00619338482061767 1.44350852129058 0.59375 10.1 10 1 decreased blood urea nitrogen level 3.36387505386138e-05 0.000978671251050314 1.43660178195427 0.590909090909091 10.1 10 1 abnormal germ layer development 0.00326146629512021 0.0335677275831593 1.43660178195427 0.590909090909091 10.1 10 1 intestinal inflammation 0.00326146629512021 0.0335677275831593 1.43660178195427 0.590909090909091 10.1 10 1 increased skin papilloma incidence 0.00326146629512021 0.0335677275831593 1.43660178195427 0.590909090909091 10.1 10 1 failure of palatal shelf elevation 0.00326146629512021 0.0335677275831593 1.43660178195427 0.590909090909091 10.1 10 1 small lung 9.628548924728e-06 0.000341128724807604 1.43010132140244 0.588235294117647 10.1 10 1 abnormal bone marrow cavity morphology 0.0102004788415298 0.0739757758551177 1.43010132140244 0.588235294117647 10.1 10 1 hyperlipidemia 0.0102004788415298 0.0739757758551177 1.43010132140244 0.588235294117647 10.1 10 1 increased regulatory T cell number 0.0102004788415298 0.0739757758551177 1.43010132140244 0.588235294117647 10.1 10 1 abnormal ectoplacental cone morphology 0.0102004788415298 0.0739757758551177 1.43010132140244 0.588235294117647 10.1 10 1 failure to gastrulate 2.81965323413276e-05 0.000845046677097017 1.42699240548634 0.58695652173913 10.1 10 1 short sternum 0.000885313300268952 0.0131084335382084 1.42516993753553 0.586206896551724 10.1 10 1 abnormal CD8-positive, alpha-beta T cell physiology 0.000885313300268952 0.0131084335382084 1.42516993753553 0.586206896551724 10.1 10 1 reduced long term depression 0.000245710433914992 0.00459552409295896 1.41818381039075 0.583333333333333 10.1 10 1 small lymph nodes 0.00268952691956353 0.0291511904680361 1.41818381039075 0.583333333333333 10.1 10 1 abnormal tumor morphology 0.00268952691956353 0.0291511904680361 1.41818381039075 0.583333333333333 10.1 10 1 increased hemangiosarcoma incidence 0.00268952691956353 0.0291511904680361 1.41818381039075 0.583333333333333 10.1 10 1 interstitial pneumonia 0.0330783364164951 0.169131267905512 1.41818381039075 0.583333333333333 10.1 10 1 abnormal gastrocnemius morphology 0.0330783364164951 0.169131267905512 1.41818381039075 0.583333333333333 10.1 10 1 small intestinal inflammation 0.0330783364164951 0.169131267905512 1.41818381039075 0.583333333333333 10.1 10 1 absent ovary 0.0330783364164951 0.169131267905512 1.41818381039075 0.583333333333333 10.1 10 1 increased osteosarcoma incidence 0.0330783364164951 0.169131267905512 1.41818381039075 0.583333333333333 10.1 10 1 abnormal defecation 0.0330783364164951 0.169131267905512 1.41818381039075 0.583333333333333 10.1 10 1 abnormal B cell proliferation 0.0330783364164951 0.169131267905512 1.41818381039075 0.583333333333333 10.1 10 1 abnormal somatic nervous system physiology 0.0330783364164951 0.169131267905512 1.41818381039075 0.583333333333333 10.1 10 1 decreased keratinocyte proliferation 0.0330783364164951 0.169131267905512 1.41818381039075 0.583333333333333 10.1 10 1 impaired behavioral response to cocaine 0.0330783364164951 0.169131267905512 1.41818381039075 0.583333333333333 10.1 10 1 decreased red blood cell distribution width 0.0330783364164951 0.169131267905512 1.41818381039075 0.583333333333333 10.1 10 1 persistent right dorsal aorta 0.0330783364164951 0.169131267905512 1.41818381039075 0.583333333333333 10.1 10 1 abnormal placenta morphology 6.80478543352589e-08 4.6375078810673e-06 1.41561928270469 0.582278481012658 10.1 10 1 increased T cell proliferation 5.02914542604649e-10 5.95714249870983e-08 1.40871662874595 0.579439252336449 10.1 10 1 thrombocytopenia 4.69252824833084e-13 1.11168228740219e-10 1.40840323238805 0.579310344827586 10.1 10 1 stereotypic behavior 0.00832038409898993 0.0654966944501185 1.4075207742224 0.578947368421053 10.1 10 1 maternal imprinting 0.00832038409898993 0.0654966944501185 1.4075207742224 0.578947368421053 10.1 10 1 absent amnion 0.00832038409898993 0.0654966944501185 1.4075207742224 0.578947368421053 10.1 10 1 Leydig cell hypoplasia 0.00832038409898993 0.0654966944501185 1.4075207742224 0.578947368421053 10.1 10 1 trabecula carnea hypoplasia 5.76130232183656e-05 0.00150532473281745 1.40467729791084 0.577777777777778 10.1 10 1 abnormal myocardial trabeculae morphology 5.76130232183656e-05 0.00150532473281745 1.40467729791084 0.577777777777778 10.1 10 1 liver hypoplasia 1.64199126846744e-05 0.000544593770708367 1.40259937291393 0.576923076923077 10.1 10 1 abnormal leukocyte cell number 0.00221276189420375 0.0253651853079807 1.40259937291393 0.576923076923077 10.1 10 1 increased leukemia incidence 0.00221276189420375 0.0253651853079807 1.40259937291393 0.576923076923077 10.1 10 1 increased spleen weight 2.9680631494336e-10 3.88581951800846e-08 1.3984619116369 0.575221238938053 10.1 10 1 decreased tumor growth/size 1.36707405158244e-05 0.000465835164837168 1.39567295625756 0.574074074074074 10.1 10 1 decreased erythrocyte cell number 1.6391827593306e-13 4.29207064614196e-11 1.39366561894632 0.573248407643312 10.1 10 1 abnormal spleen white pulp morphology 0.000140234187725576 0.00305060341147461 1.38924128364808 0.571428571428571 10.1 10 1 abnormal spleen germinal center morphology 0.00181743224139447 0.022156544258372 1.38924128364808 0.571428571428571 10.1 10 1 abnormal brainstem morphology 0.00181743224139447 0.022156544258372 1.38924128364808 0.571428571428571 10.1 10 1 prolonged QRS complex duration 0.00181743224139447 0.022156544258372 1.38924128364808 0.571428571428571 10.1 10 1 subcutaneous edema 0.00181743224139447 0.022156544258372 1.38924128364808 0.571428571428571 10.1 10 1 abnormal embryonic/fetal subventricular zone morphology 0.00677634431986632 0.0572365246032852 1.38924128364808 0.571428571428571 10.1 10 1 increased acute inflammation 0.00677634431986632 0.0572365246032852 1.38924128364808 0.571428571428571 10.1 10 1 vascular ring 0.00677634431986632 0.0572365246032852 1.38924128364808 0.571428571428571 10.1 10 1 absent segment of posterior cerebral artery 0.00677634431986632 0.0572365246032852 1.38924128364808 0.571428571428571 10.1 10 1 abnormal blood flow velocity 0.0264806490241659 0.146067271983839 1.38924128364808 0.571428571428571 10.1 10 1 increased aggression towards males 0.0264806490241659 0.146067271983839 1.38924128364808 0.571428571428571 10.1 10 1 abnormal spleen periarteriolar lymphoid sheath morphology 0.0264806490241659 0.146067271983839 1.38924128364808 0.571428571428571 10.1 10 1 absent otoliths 0.0264806490241659 0.146067271983839 1.38924128364808 0.571428571428571 10.1 10 1 abnormal kidney medulla morphology 0.0264806490241659 0.146067271983839 1.38924128364808 0.571428571428571 10.1 10 1 intestinal obstruction 0.0264806490241659 0.146067271983839 1.38924128364808 0.571428571428571 10.1 10 1 amyloid beta deposits 0.0264806490241659 0.146067271983839 1.38924128364808 0.571428571428571 10.1 10 1 failure of zygotic cell division 0.0264806490241659 0.146067271983839 1.38924128364808 0.571428571428571 10.1 10 1 lysosomal protein accumulation 0.0264806490241659 0.146067271983839 1.38924128364808 0.571428571428571 10.1 10 1 decreased tongue size 0.0264806490241659 0.146067271983839 1.38924128364808 0.571428571428571 10.1 10 1 abnormal dermal layer morphology 0.000500556202880221 0.0082733126555784 1.38924128364808 0.571428571428571 10.1 10 1 increased carcinoma incidence 0.000500556202880221 0.0082733126555784 1.38924128364808 0.571428571428571 10.1 10 1 abnormal inflammatory response 7.88310415343801e-07 4.0018819554443e-05 1.38441752919097 0.569444444444444 10.1 10 1 abnormal myelopoiesis 0.000116000174021679 0.00267176326739746 1.38134786726372 0.568181818181818 10.1 10 1 lung inflammation 2.08261064169072e-11 3.3422541749714e-09 1.37647252184984 0.566176470588235 10.1 10 1 enlarged spleen 1.8490886436776e-22 1.31417371461372e-19 1.37597595889102 0.565972222222222 10.1 10 1 abnormal immune system morphology 9.58544613585145e-05 0.00227083783456481 1.37414083491278 0.565217391304348 10.1 10 1 abnormal postnatal growth 0.00551386217405388 0.0497848717167297 1.37414083491278 0.565217391304348 10.1 10 1 increased susceptibility to fungal infection 0.00551386217405388 0.0497848717167297 1.37414083491278 0.565217391304348 10.1 10 1 abnormal chondrocyte physiology 0.00551386217405388 0.0497848717167297 1.37414083491278 0.565217391304348 10.1 10 1 abnormal response to injury 0.000339853989664203 0.00599565105879224 1.37143049796028 0.564102564102564 10.1 10 1 decreased circulating total protein level 2.25992184798206e-05 0.000707113911554136 1.37029708432561 0.563636363636364 10.1 10 1 scoliosis 0.00122184160386213 0.0169555598394097 1.36753438859108 0.5625 10.1 10 1 abnormal spongiotrophoblast layer morphology 0.00122184160386213 0.0169555598394097 1.36753438859108 0.5625 10.1 10 1 abnormal epididymis epithelium morphology 0.0212179680152373 0.12975091302085 1.36753438859108 0.5625 10.1 10 1 increased thymus weight 0.0212179680152373 0.12975091302085 1.36753438859108 0.5625 10.1 10 1 abnormal Langerhans cell physiology 0.0212179680152373 0.12975091302085 1.36753438859108 0.5625 10.1 10 1 kidney degeneration 0.0212179680152373 0.12975091302085 1.36753438859108 0.5625 10.1 10 1 decreased birth body size 1.59303699723191e-09 1.76119090249527e-07 1.36486862954899 0.56140350877193 10.1 10 1 abnormal cell differentiation 0.000279653017924344 0.00513385152831591 1.36382833333744 0.560975609756098 10.1 10 1 abnormal inner ear vestibule morphology 0.00448437720454103 0.0426573166206341 1.36145645797512 0.56 10.1 10 1 abnormal primitive streak morphology 0.00448437720454103 0.0426573166206341 1.36145645797512 0.56 10.1 10 1 abnormal preimplantation embryo development 0.00448437720454103 0.0426573166206341 1.36145645797512 0.56 10.1 10 1 abnormal oocyte morphology 0.00100067017962831 0.0145140937132677 1.35859625533231 0.558823529411765 10.1 10 1 decreased cytotoxic T cell cytolysis 0.00100067017962831 0.0145140937132677 1.35859625533231 0.558823529411765 10.1 10 1 abnormal cytokine secretion 4.00103579022184e-12 7.65582809859755e-10 1.35766761811062 0.558441558441558 10.1 10 1 abnormal spleen morphology 2.01630185162153e-13 5.01555085590856e-11 1.35530866608771 0.557471264367816 10.1 10 1 abnormal vitelline vasculature morphology 2.57137007341883e-09 2.72182257771461e-07 1.35300020668335 0.556521739130435 10.1 10 1 increased susceptibility to bacterial infection induced morbidity/mortality 2.52168509107407e-06 0.000108149856276668 1.35065124799119 0.555555555555556 10.1 10 1 lowered ear position 0.0170210575088552 0.108563796290454 1.35065124799119 0.555555555555556 10.1 10 1 abnormal Peyer's patch follicle morphology 0.0170210575088552 0.108563796290454 1.35065124799119 0.555555555555556 10.1 10 1 increased circulating glycerol level 0.0170210575088552 0.108563796290454 1.35065124799119 0.555555555555556 10.1 10 1 absent ureter 0.0170210575088552 0.108563796290454 1.35065124799119 0.555555555555556 10.1 10 1 absent inner cell mass 0.0170210575088552 0.108563796290454 1.35065124799119 0.555555555555556 10.1 10 1 jerky movement 0.0170210575088552 0.108563796290454 1.35065124799119 0.555555555555556 10.1 10 1 abnormal pregnancy 0.0170210575088552 0.108563796290454 1.35065124799119 0.555555555555556 10.1 10 1 small thoracic cage 0.0170210575088552 0.108563796290454 1.35065124799119 0.555555555555556 10.1 10 1 increased gastrointestinal tumor incidence 0.0170210575088552 0.108563796290454 1.35065124799119 0.555555555555556 10.1 10 1 decreased tumor latency 0.0170210575088552 0.108563796290454 1.35065124799119 0.555555555555556 10.1 10 1 impaired leukocyte tethering or rolling 0.0170210575088552 0.108563796290454 1.35065124799119 0.555555555555556 10.1 10 1 abnormal sympathetic neuron morphology 0.0886400877093631 0.295565976108634 1.35065124799119 0.555555555555556 10.1 10 1 abnormal lens vesicle development 0.0886400877093631 0.295565976108634 1.35065124799119 0.555555555555556 10.1 10 1 long gestation period 0.0886400877093631 0.295565976108634 1.35065124799119 0.555555555555556 10.1 10 1 abnormal thymus lobule morphology 0.0886400877093631 0.295565976108634 1.35065124799119 0.555555555555556 10.1 10 1 abnormal posterior semicircular canal morphology 0.0886400877093631 0.295565976108634 1.35065124799119 0.555555555555556 10.1 10 1 decreased circulating bicarbonate level 0.0886400877093631 0.295565976108634 1.35065124799119 0.555555555555556 10.1 10 1 abnormal lens capsule morphology 0.0886400877093631 0.295565976108634 1.35065124799119 0.555555555555556 10.1 10 1 decreased susceptibility to induced choroidal neovascularization 0.0886400877093631 0.295565976108634 1.35065124799119 0.555555555555556 10.1 10 1 decreased fear-related response 0.0886400877093631 0.295565976108634 1.35065124799119 0.555555555555556 10.1 10 1 impaired febrile response 0.0886400877093631 0.295565976108634 1.35065124799119 0.555555555555556 10.1 10 1 abnormal bony labyrinth 0.0886400877093631 0.295565976108634 1.35065124799119 0.555555555555556 10.1 10 1 absent adrenal gland 0.0886400877093631 0.295565976108634 1.35065124799119 0.555555555555556 10.1 10 1 increased tidal volume 0.0886400877093631 0.295565976108634 1.35065124799119 0.555555555555556 10.1 10 1 enhanced conditioned place preference behavior 0.0886400877093631 0.295565976108634 1.35065124799119 0.555555555555556 10.1 10 1 decreased transitional stage T1 B cell number 0.0886400877093631 0.295565976108634 1.35065124799119 0.555555555555556 10.1 10 1 abnormal hippocampus granule cell morphology 0.0886400877093631 0.295565976108634 1.35065124799119 0.555555555555556 10.1 10 1 abnormal cerebellar layer morphology 0.0886400877093631 0.295565976108634 1.35065124799119 0.555555555555556 10.1 10 1 shortened ST segment 0.0886400877093631 0.295565976108634 1.35065124799119 0.555555555555556 10.1 10 1 iris coloboma 0.0886400877093631 0.295565976108634 1.35065124799119 0.555555555555556 10.1 10 1 abnormal pulmonary alveolar system morphology 0.0886400877093631 0.295565976108634 1.35065124799119 0.555555555555556 10.1 10 1 abnormal pulmonary alveolar parenchyma morphology 0.0886400877093631 0.295565976108634 1.35065124799119 0.555555555555556 10.1 10 1 abnormal oxidative phosphorylation 0.0886400877093631 0.295565976108634 1.35065124799119 0.555555555555556 10.1 10 1 increased core body temperature 0.0886400877093631 0.295565976108634 1.35065124799119 0.555555555555556 10.1 10 1 decreased bone trabecular spacing 0.0886400877093631 0.295565976108634 1.35065124799119 0.555555555555556 10.1 10 1 increased myeloid cell number 0.0886400877093631 0.295565976108634 1.35065124799119 0.555555555555556 10.1 10 1 abnormal infrahyoid muscle connection 0.0886400877093631 0.295565976108634 1.35065124799119 0.555555555555556 10.1 10 1 abnormal coronary sinus connection 0.0886400877093631 0.295565976108634 1.35065124799119 0.555555555555556 10.1 10 1 increased cardiac muscle glycogen level 0.0886400877093631 0.295565976108634 1.35065124799119 0.555555555555556 10.1 10 1 decreased fatty acid oxidation 0.0886400877093631 0.295565976108634 1.35065124799119 0.555555555555556 10.1 10 1 abnormal apoptosis 4.43502118195218e-05 0.0012123203505611 1.35065124799119 0.555555555555556 10.1 10 1 abnormal cell adhesion 4.43502118195218e-05 0.0012123203505611 1.35065124799119 0.555555555555556 10.1 10 1 abnormal bone trabecula morphology 0.00364627593370696 0.0362804455403842 1.35065124799119 0.555555555555556 10.1 10 1 decreased lymphocyte cell number 4.33174955787955e-10 5.25620830498799e-08 1.3485408554162 0.5546875 10.1 10 1 abnormal T cell activation 2.08347502625982e-06 9.25472165682376e-05 1.34700083921283 0.554054054054054 10.1 10 1 short mandible 3.65257882329504e-05 0.00104434365780993 1.34582749353408 0.553571428571429 10.1 10 1 incomplete somite formation 0.000670243992198006 0.0104528647686053 1.34354255721229 0.552631578947368 10.1 10 1 decreased neuron apoptosis 0.000670243992198006 0.0104528647686053 1.34354255721229 0.552631578947368 10.1 10 1 thrombocytosis 3.00691062949452e-05 0.000890439308436621 1.34133641179815 0.551724137931034 10.1 10 1 decreased trophoblast giant cell number 0.00296465555354895 0.0317869857304009 1.34133641179815 0.551724137931034 10.1 10 1 blood in lymph vessels 0.00296465555354895 0.0317869857304009 1.34133641179815 0.551724137931034 10.1 10 1 organ of Corti degeneration 0.000127470150108052 0.00288256362176164 1.33962552351779 0.551020408163265 10.1 10 1 abnormal vascular regression 0.013671264742997 0.0927892798041066 1.33714473551128 0.55 10.1 10 1 abnormal hearing physiology 0.013671264742997 0.0927892798041066 1.33714473551128 0.55 10.1 10 1 abnormal Peyer's patch T cell area morphology 0.013671264742997 0.0927892798041066 1.33714473551128 0.55 10.1 10 1 abnormal physiological neovascularization 0.013671264742997 0.0927892798041066 1.33714473551128 0.55 10.1 10 1 increased skin tumor incidence 0.013671264742997 0.0927892798041066 1.33714473551128 0.55 10.1 10 1 absent ductus venosus valve 0.013671264742997 0.0927892798041066 1.33714473551128 0.55 10.1 10 1 anemia 3.63449422268059e-15 1.20544058385573e-12 1.33656862834389 0.549763033175355 10.1 10 1 abnormal CD4-positive, alpha-beta T cell physiology 4.86901219025411e-06 0.000187777795709412 1.33543264238002 0.549295774647887 10.1 10 1 failure of chorioallantoic fusion 0.000104635016494782 0.00244393993925607 1.33476123330894 0.549019607843137 10.1 10 1 abnormal embryo size 9.50264065451e-09 9.26973279533084e-07 1.33391751571519 0.548672566371681 10.1 10 1 osteopetrosis 0.00241060988218017 0.0270218488391995 1.33322348995259 0.548387096774194 10.1 10 1 abnormal postnatal growth/weight/body size 0.00241060988218017 0.0270218488391995 1.33322348995259 0.548387096774194 10.1 10 1 abnormal capillary morphology 0.00241060988218017 0.0270218488391995 1.33322348995259 0.548387096774194 10.1 10 1 astrocytosis 4.0115808258377e-06 0.000166313455071188 1.3321491761009 0.547945205479452 10.1 10 1 spina bifida 0.000448423180796536 0.00756239093038227 1.33135623016274 0.547619047619048 10.1 10 1 lethality throughout fetal growth and development, complete penetrance 1.37277784462105e-13 3.79420543166097e-11 1.33074691381027 0.547368421052632 10.1 10 1 increased inflammatory response 1.59704695593181e-07 9.80902297007501e-06 1.33074691381027 0.547368421052632 10.1 10 1 decreased neutrophil cell number 6.48983103075742e-09 6.58916517918738e-07 1.32987199802209 0.547008547008547 10.1 10 1 abnormal ovarian folliculogenesis 0.00196038476650418 0.0234445053205729 1.32609395257317 0.545454545454545 10.1 10 1 decreased brown adipose tissue amount 0.00196038476650418 0.0234445053205729 1.32609395257317 0.545454545454545 10.1 10 1 increased cardiomyocyte apoptosis 0.00196038476650418 0.0234445053205729 1.32609395257317 0.545454545454545 10.1 10 1 abnormal locomotor coordination 0.00196038476650418 0.0234445053205729 1.32609395257317 0.545454545454545 10.1 10 1 abnormal T cell subpopulation ratio 0.00196038476650418 0.0234445053205729 1.32609395257317 0.545454545454545 10.1 10 1 abnormal channel response 0.0109941979495617 0.078137335427242 1.32609395257317 0.545454545454545 10.1 10 1 abnormal blood-brain barrier function 0.0109941979495617 0.078137335427242 1.32609395257317 0.545454545454545 10.1 10 1 abnormal mesenteric lymph node morphology 0.0109941979495617 0.078137335427242 1.32609395257317 0.545454545454545 10.1 10 1 pulmonary vascular congestion 0.0109941979495617 0.078137335427242 1.32609395257317 0.545454545454545 10.1 10 1 absent semicircular canals 0.0688996153074993 0.282094713743142 1.32609395257317 0.545454545454545 10.1 10 1 abnormal sphenoid bone morphology 0.0688996153074993 0.282094713743142 1.32609395257317 0.545454545454545 10.1 10 1 abnormal hemoglobin 0.0688996153074993 0.282094713743142 1.32609395257317 0.545454545454545 10.1 10 1 impaired myelopoiesis 0.0688996153074993 0.282094713743142 1.32609395257317 0.545454545454545 10.1 10 1 abnormal proximal-distal axis patterning 0.0688996153074993 0.282094713743142 1.32609395257317 0.545454545454545 10.1 10 1 abnormal palate development 0.0688996153074993 0.282094713743142 1.32609395257317 0.545454545454545 10.1 10 1 palatal shelf hypoplasia 0.0688996153074993 0.282094713743142 1.32609395257317 0.545454545454545 10.1 10 1 common atrioventricular valve 0.0688996153074993 0.282094713743142 1.32609395257317 0.545454545454545 10.1 10 1 abnormal dendritic cell chemotaxis 0.0688996153074993 0.282094713743142 1.32609395257317 0.545454545454545 10.1 10 1 abnormal pulmonary alveolar sac morphology 0.0688996153074993 0.282094713743142 1.32609395257317 0.545454545454545 10.1 10 1 thin hypoglossal nerve 0.0688996153074993 0.282094713743142 1.32609395257317 0.545454545454545 10.1 10 1 increased insulin sensitivity 1.82372666001561e-10 2.52028892599379e-08 1.32609395257317 0.545454545454545 10.1 10 1 abnormal T cell differentiation 8.96897372211641e-08 5.91020426061713e-06 1.32390567872404 0.544554455445545 10.1 10 1 abnormal nervous system morphology 2.24009346116639e-06 9.86235837991397e-05 1.32329628600656 0.544303797468354 10.1 10 1 pericardial edema 1.13162682910045e-05 0.000388265067225845 1.32284372229725 0.544117647058823 10.1 10 1 decreased susceptibility to induced arthritis 5.77923666267606e-05 0.00150532473281745 1.32221648487559 0.543859649122807 10.1 10 1 abnormal myelin sheath morphology 0.000299852744867849 0.00544440659021004 1.32128926433921 0.543478260869565 10.1 10 1 embryonic lethality between implantation and placentation, complete penetrance 0.000299852744867849 0.00544440659021004 1.32128926433921 0.543478260869565 10.1 10 1 abnormal artery morphology 0.00159455552701665 0.0201409743941904 1.31977921946568 0.542857142857143 10.1 10 1 decreased circulating thyroxine level 0.00159455552701665 0.0201409743941904 1.31977921946568 0.542857142857143 10.1 10 1 decreased body height 0.00885171292936066 0.0680389878130877 1.31688496679141 0.541666666666667 10.1 10 1 decreased metastatic potential 0.00885171292936066 0.0680389878130877 1.31688496679141 0.541666666666667 10.1 10 1 abnormal primitive streak formation 0.00885171292936066 0.0680389878130877 1.31688496679141 0.541666666666667 10.1 10 1 prolonged QT interval 0.00885171292936066 0.0680389878130877 1.31688496679141 0.541666666666667 10.1 10 1 decreased T cell proliferation 1.93739231412674e-10 2.60500723318393e-08 1.31414716020764 0.540540540540541 10.1 10 1 short stride length 0.000200468477740958 0.00386562277814443 1.31283301304744 0.54 10.1 10 1 embryonic lethality, complete penetrance 1.42049971210159e-20 7.63336242259402e-18 1.31085149334819 0.539184952978056 10.1 10 1 decreased monocyte cell number 2.61373850983133e-05 0.000801578436016951 1.309092748053 0.538461538461538 10.1 10 1 abnormal brain wave pattern 0.000163913810719104 0.00341201342396461 1.309092748053 0.538461538461538 10.1 10 1 heart inflammation 0.00713459506660116 0.0587212135004652 1.309092748053 0.538461538461538 10.1 10 1 abnormal erythrocyte osmotic lysis 0.00713459506660116 0.0587212135004652 1.309092748053 0.538461538461538 10.1 10 1 decreased bone resorption 0.00713459506660116 0.0587212135004652 1.309092748053 0.538461538461538 10.1 10 1 increased thymocyte apoptosis 0.00713459506660116 0.0587212135004652 1.309092748053 0.538461538461538 10.1 10 1 absent trabeculae carneae 0.0539529564166137 0.239443316835552 1.309092748053 0.538461538461538 10.1 10 1 abnormal renal/urinary system morphology 0.0539529564166137 0.239443316835552 1.309092748053 0.538461538461538 10.1 10 1 uterus hypoplasia 0.0539529564166137 0.239443316835552 1.309092748053 0.538461538461538 10.1 10 1 abnormal pulmonary alveolus epithelial cell morphology 0.0539529564166137 0.239443316835552 1.309092748053 0.538461538461538 10.1 10 1 abnormal lung interstitium morphology 0.0539529564166137 0.239443316835552 1.309092748053 0.538461538461538 10.1 10 1 abnormal coping response 0.0539529564166137 0.239443316835552 1.309092748053 0.538461538461538 10.1 10 1 abnormal telomere length 0.0539529564166137 0.239443316835552 1.309092748053 0.538461538461538 10.1 10 1 axonal dystrophy 0.0539529564166137 0.239443316835552 1.309092748053 0.538461538461538 10.1 10 1 muscle fatigue 0.0539529564166137 0.239443316835552 1.309092748053 0.538461538461538 10.1 10 1 abnormal exocrine pancreas morphology 0.0539529564166137 0.239443316835552 1.309092748053 0.538461538461538 10.1 10 1 hyperalgesia 0.0539529564166137 0.239443316835552 1.309092748053 0.538461538461538 10.1 10 1 increased prostaglandin level 0.0539529564166137 0.239443316835552 1.309092748053 0.538461538461538 10.1 10 1 abnormal heart development 7.39536801368022e-11 1.14974862087685e-08 1.3079091198902 0.537974683544304 10.1 10 1 abnormal lung morphology 1.57297879807257e-08 1.3492361242088e-06 1.30752120813937 0.53781512605042 10.1 10 1 abnormal definitive hematopoiesis 5.71521435661339e-07 3.024807598314e-05 1.3070818528947 0.537634408602151 10.1 10 1 increased cell proliferation 0.000134028379125143 0.0029767463667303 1.30562953972482 0.537037037037037 10.1 10 1 diluted coat color 0.000134028379125143 0.0029767463667303 1.30562953972482 0.537037037037037 10.1 10 1 abnormal mandible morphology 0.000134028379125143 0.0029767463667303 1.30562953972482 0.537037037037037 10.1 10 1 decreased platelet aggregation 0.000134028379125143 0.0029767463667303 1.30562953972482 0.537037037037037 10.1 10 1 liver fibrosis 0.000859322498775687 0.0128741642256753 1.3045314492793 0.536585365853659 10.1 10 1 increased bone trabecula number 0.000859322498775687 0.0128741642256753 1.3045314492793 0.536585365853659 10.1 10 1 abnormal stria vascularis morphology 0.0057564801940675 0.0505980370414944 1.30241370342008 0.535714285714286 10.1 10 1 reddish skin 0.0057564801940675 0.0505980370414944 1.30241370342008 0.535714285714286 10.1 10 1 abnormal somite shape 0.0057564801940675 0.0505980370414944 1.30241370342008 0.535714285714286 10.1 10 1 premature aging 0.0057564801940675 0.0505980370414944 1.30241370342008 0.535714285714286 10.1 10 1 hypoxia 0.0057564801940675 0.0505980370414944 1.30241370342008 0.535714285714286 10.1 10 1 edema 1.91137667249931e-11 3.16969964856135e-09 1.30039445736826 0.534883720930233 10.1 10 1 impaired macrophage phagocytosis 0.000699659699328944 0.0108099596402531 1.30039445736826 0.534883720930233 10.1 10 1 kidney failure 0.000699659699328944 0.0108099596402531 1.30039445736826 0.534883720930233 10.1 10 1 embryonic lethality between implantation and somite formation, complete penetrance 1.20610610762803e-15 4.28598420389246e-13 1.29993291541356 0.53469387755102 10.1 10 1 cochlear ganglion degeneration 8.96227766373638e-05 0.00214362170082156 1.29941964892945 0.53448275862069 10.1 10 1 abnormal embryonic neuroepithelium morphology 8.96227766373638e-05 0.00214362170082156 1.29941964892945 0.53448275862069 10.1 10 1 abnormal cell migration 0.000569813312071153 0.0092127143110254 1.29662519807154 0.533333333333333 10.1 10 1 abnormal eating behavior 7.32938538229662e-05 0.00183234634557415 1.29662519807154 0.533333333333333 10.1 10 1 abnormal synaptic transmission 0.00464898719261239 0.0432312360434517 1.29662519807154 0.533333333333333 10.1 10 1 liver hemorrhage 0.00464898719261239 0.0432312360434517 1.29662519807154 0.533333333333333 10.1 10 1 abnormal cellular respiration 0.00464898719261239 0.0432312360434517 1.29662519807154 0.533333333333333 10.1 10 1 absent incisors 0.0424892834704876 0.203645650544967 1.29662519807154 0.533333333333333 10.1 10 1 abnormal prostate gland morphology 0.0424892834704876 0.203645650544967 1.29662519807154 0.533333333333333 10.1 10 1 hyperpigmentation 0.0424892834704876 0.203645650544967 1.29662519807154 0.533333333333333 10.1 10 1 audiogenic seizures 0.0424892834704876 0.203645650544967 1.29662519807154 0.533333333333333 10.1 10 1 increased airway responsiveness 0.0424892834704876 0.203645650544967 1.29662519807154 0.533333333333333 10.1 10 1 abnormal bronchus morphology 0.0424892834704876 0.203645650544967 1.29662519807154 0.533333333333333 10.1 10 1 delayed intramembranous bone ossification 0.0424892834704876 0.203645650544967 1.29662519807154 0.533333333333333 10.1 10 1 abnormal pericyte morphology 0.0424892834704876 0.203645650544967 1.29662519807154 0.533333333333333 10.1 10 1 decreased aggression towards males 0.0424892834704876 0.203645650544967 1.29662519807154 0.533333333333333 10.1 10 1 abnormal trophectoderm morphology 0.0424892834704876 0.203645650544967 1.29662519807154 0.533333333333333 10.1 10 1 abnormal olfactory nerve morphology 0.0424892834704876 0.203645650544967 1.29662519807154 0.533333333333333 10.1 10 1 abnormal energy homeostasis 0.0424892834704876 0.203645650544967 1.29662519807154 0.533333333333333 10.1 10 1 abnormal aorta wall morphology 0.0424892834704876 0.203645650544967 1.29662519807154 0.533333333333333 10.1 10 1 bicuspid aortic valve 0.0424892834704876 0.203645650544967 1.29662519807154 0.533333333333333 10.1 10 1 abnormal coronary vessel morphology 0.0424892834704876 0.203645650544967 1.29662519807154 0.533333333333333 10.1 10 1 abnormal dendritic cell physiology 1.4502655492776e-07 9.13300140209629e-06 1.29511044900837 0.532710280373832 10.1 10 1 abnormal myocardium layer morphology 6.50595274327377e-06 0.000236256313122533 1.29252195377385 0.531645569620253 10.1 10 1 increased dopamine level 0.00375788059760731 0.0368746666136023 1.29156025589157 0.53125 10.1 10 1 increased fibroblast apoptosis 0.00375788059760731 0.0368746666136023 1.29156025589157 0.53125 10.1 10 1 increased sarcoma incidence 0.000378237653258305 0.00655655862355424 1.2900097633875 0.530612244897959 10.1 10 1 abnormal vascular development 4.01053045036663e-05 0.00110846605503189 1.28925800944614 0.53030303030303 10.1 10 1 pale yolk sac 4.37234805411552e-06 0.000176040463578132 1.28881420290244 0.530120481927711 10.1 10 1 increased B cell number 5.43494505908509e-08 3.77286548559504e-06 1.2883134980839 0.52991452991453 10.1 10 1 impaired hematopoiesis 0.000308281121642904 0.00553449280085155 1.28709118926219 0.529411764705882 10.1 10 1 increased lung adenocarcinoma incidence 0.000308281121642904 0.00553449280085155 1.28709118926219 0.529411764705882 10.1 10 1 abnormal thrombosis 0.000308281121642904 0.00553449280085155 1.28709118926219 0.529411764705882 10.1 10 1 short maxilla 0.00304006367673956 0.0321110759910389 1.28709118926219 0.529411764705882 10.1 10 1 enlarged liver sinusoidal spaces 0.00304006367673956 0.0321110759910389 1.28709118926219 0.529411764705882 10.1 10 1 thin skin 0.00304006367673956 0.0321110759910389 1.28709118926219 0.529411764705882 10.1 10 1 increased susceptibility to viral infection induced morbidity/mortality 0.00304006367673956 0.0321110759910389 1.28709118926219 0.529411764705882 10.1 10 1 abnormal adipose tissue morphology 0.0336126433356583 0.170635612851939 1.28709118926219 0.529411764705882 10.1 10 1 abnormal interatrial septum morphology 0.0336126433356583 0.170635612851939 1.28709118926219 0.529411764705882 10.1 10 1 absence seizures 0.0336126433356583 0.170635612851939 1.28709118926219 0.529411764705882 10.1 10 1 aminoaciduria 0.0336126433356583 0.170635612851939 1.28709118926219 0.529411764705882 10.1 10 1 increased brain size 0.0336126433356583 0.170635612851939 1.28709118926219 0.529411764705882 10.1 10 1 abnormal circulating chemokine level 0.0336126433356583 0.170635612851939 1.28709118926219 0.529411764705882 10.1 10 1 increased trabecular bone mass 0.0336126433356583 0.170635612851939 1.28709118926219 0.529411764705882 10.1 10 1 embryonic lethality between somite formation and embryo turning, complete penetrance 2.68408089511687e-05 0.000814225759341856 1.28504818737447 0.528571428571429 10.1 10 1 abnormal muscle physiology 2.40909824946826e-06 0.00010430688312223 1.28387747842758 0.528089887640449 10.1 10 1 abnormal trophoblast giant cell morphology 0.00246122612382065 0.0273316963526958 1.28311868559163 0.527777777777778 10.1 10 1 abnormal platelet physiology 0.000204941159265198 0.00390236136130139 1.28189082082073 0.527272727272727 10.1 10 1 increased macrophage cell number 0.000167156320753684 0.00345063359232191 1.27956434020218 0.526315789473684 10.1 10 1 impaired branching involved in ureteric bud morphogenesis 0.00199400280745801 0.0237893620314235 1.27956434020218 0.526315789473684 10.1 10 1 flaky skin 0.0266884724087055 0.146067271983839 1.27956434020218 0.526315789473684 10.1 10 1 shiny skin 0.0266884724087055 0.146067271983839 1.27956434020218 0.526315789473684 10.1 10 1 abnormal stationary movement 0.0266884724087055 0.146067271983839 1.27956434020218 0.526315789473684 10.1 10 1 unresponsive to tactile stimuli 0.0266884724087055 0.146067271983839 1.27956434020218 0.526315789473684 10.1 10 1 increased malignant tumor incidence 0.0266884724087055 0.146067271983839 1.27956434020218 0.526315789473684 10.1 10 1 abnormal sternebra morphology 0.0266884724087055 0.146067271983839 1.27956434020218 0.526315789473684 10.1 10 1 increased liver cholesterol level 0.0266884724087055 0.146067271983839 1.27956434020218 0.526315789473684 10.1 10 1 decreased circulating magnesium level 0.0266884724087055 0.146067271983839 1.27956434020218 0.526315789473684 10.1 10 1 decreased liver glycogen level 0.0266884724087055 0.146067271983839 1.27956434020218 0.526315789473684 10.1 10 1 abnormal immune system physiology 4.53683686390813e-08 3.27112513013666e-06 1.27440480657233 0.524193548387097 10.1 10 1 abnormal pancreas morphology 0.00131131174855275 0.0174391300307673 1.27347117667741 0.523809523809524 10.1 10 1 abnormal scapula morphology 0.0212556772084408 0.12975091302085 1.27347117667741 0.523809523809524 10.1 10 1 trunk curl 0.0212556772084408 0.12975091302085 1.27347117667741 0.523809523809524 10.1 10 1 liver degeneration 0.0212556772084408 0.12975091302085 1.27347117667741 0.523809523809524 10.1 10 1 embryonic lethality at implantation, complete penetrance 0.0212556772084408 0.12975091302085 1.27347117667741 0.523809523809524 10.1 10 1 skin lesions 9.08182060235445e-05 0.0021618209328571 1.27347117667741 0.523809523809524 10.1 10 1 increased T cell number 4.4231272255812e-06 0.000176040463578132 1.27084003788262 0.522727272727273 10.1 10 1 abnormal inner ear morphology 0.000864315749020213 0.0128741642256753 1.26843769376564 0.521739130434783 10.1 10 1 abnormal cell death 0.000864315749020213 0.0128741642256753 1.26843769376564 0.521739130434783 10.1 10 1 fragile skeleton 0.0169727460682974 0.108563796290454 1.26843769376564 0.521739130434783 10.1 10 1 bidirectional circling 0.0169727460682974 0.108563796290454 1.26843769376564 0.521739130434783 10.1 10 1 abnormal crista ampullaris morphology 0.0169727460682974 0.108563796290454 1.26843769376564 0.521739130434783 10.1 10 1 abnormal corneal stroma morphology 0.0169727460682974 0.108563796290454 1.26843769376564 0.521739130434783 10.1 10 1 abnormal palatal shelf fusion at midline 0.0169727460682974 0.108563796290454 1.26843769376564 0.521739130434783 10.1 10 1 abnormal hematopoietic stem cell physiology 0.0169727460682974 0.108563796290454 1.26843769376564 0.521739130434783 10.1 10 1 increased susceptibility to pharmacologically induced seizures 1.98871569293384e-06 8.92768383434098e-05 1.26623554499174 0.520833333333333 10.1 10 1 decreased percent body fat/body weight 3.29828409588548e-05 0.00096523313982531 1.26554171729585 0.520547945205479 10.1 10 1 increased circulating chloride level 0.000570820926735435 0.0092127143110254 1.26420956811975 0.52 10.1 10 1 abnormal nest building behavior 0.0135829932979153 0.0927892798041066 1.26420956811975 0.52 10.1 10 1 abnormal egg cylinder morphology 0.0135829932979153 0.0927892798041066 1.26420956811975 0.52 10.1 10 1 increased pre-B cell number 0.0135829932979153 0.0927892798041066 1.26420956811975 0.52 10.1 10 1 abnormal cochlear outer hair cell morphology 0.0135829932979153 0.0927892798041066 1.26420956811975 0.52 10.1 10 1 decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 0.0135829932979153 0.0927892798041066 1.26420956811975 0.52 10.1 10 1 neurodegeneration 0.000377644959239114 0.00655655862355424 1.26060783145844 0.518518518518518 10.1 10 1 abnormal type II pneumocyte morphology 0.0108912464404872 0.0778505043698621 1.26060783145844 0.518518518518518 10.1 10 1 abnormal palate morphology 0.0108912464404872 0.0778505043698621 1.26060783145844 0.518518518518518 10.1 10 1 thick interventricular septum 0.0108912464404872 0.0778505043698621 1.26060783145844 0.518518518518518 10.1 10 1 embryonic lethality during organogenesis, complete penetrance 9.3781249688477e-30 1.37780502129673e-26 1.25899991330607 0.517857142857143 10.1 10 1 dermatitis 0.000250227975164029 0.0046450902106009 1.25750288606076 0.517241379310345 10.1 10 1 increased susceptibility to induced arthritis 0.00874772088033742 0.0680389878130877 1.25750288606076 0.517241379310345 10.1 10 1 enlarged epididymis 0.00874772088033742 0.0680389878130877 1.25750288606076 0.517241379310345 10.1 10 1 liver inflammation 1.81868190878735e-07 1.09011355376109e-05 1.25610566063181 0.516666666666667 10.1 10 1 absent mesoderm 0.000203792802534198 0.00389949689464475 1.25610566063181 0.516666666666667 10.1 10 1 intracranial hemorrhage 0.000203792802534198 0.00389949689464475 1.25610566063181 0.516666666666667 10.1 10 1 abnormal B cell differentiation 5.38026958245663e-06 0.000204753948576084 1.25566039098961 0.516483516483517 10.1 10 1 hypoglycemia 4.40135539417084e-06 0.000176040463578132 1.25479857877891 0.516129032258065 10.1 10 1 pale kidney 0.00703658965707343 0.0587212135004652 1.25479857877891 0.516129032258065 10.1 10 1 enlarged pericardium 0.00566771991815435 0.0502956104192238 1.2524220663191 0.515151515151515 10.1 10 1 belly spot 0.00566771991815435 0.0502956104192238 1.2524220663191 0.515151515151515 10.1 10 1 decreased circulating serum albumin level 2.41111388121737e-06 0.00010430688312223 1.2524220663191 0.515151515151515 10.1 10 1 ovary cysts 0.00457060171762265 0.0430431607251859 1.25031715528327 0.514285714285714 10.1 10 1 abnormal midbrain development 0.00457060171762265 0.0430431607251859 1.25031715528327 0.514285714285714 10.1 10 1 decreased triglyceride level 0.00457060171762265 0.0430431607251859 1.25031715528327 0.514285714285714 10.1 10 1 abnormal forebrain development 5.98410646077101e-05 0.00153458400218226 1.24935240439185 0.513888888888889 10.1 10 1 decreased hematocrit 1.37329077344409e-08 1.2519927689048e-06 1.24888985259459 0.513698630136986 10.1 10 1 abnormal branching of the mammary ductal tree 0.00368982785512566 0.0364224078953376 1.24843980219726 0.513513513513513 10.1 10 1 decreased width of hypertrophic chondrocyte zone 0.00368982785512566 0.0364224078953376 1.24843980219726 0.513513513513513 10.1 10 1 increased trabecular bone volume 0.00368982785512566 0.0364224078953376 1.24843980219726 0.513513513513513 10.1 10 1 reduced female fertility 1.06237672196165e-12 2.40242008716327e-10 1.24702369534359 0.512931034482759 10.1 10 1 increased hepatocyte apoptosis 0.00298169103093581 0.031900887911625 1.24675499814571 0.512820512820513 10.1 10 1 abnormal bone mineralization 2.67242218164188e-07 1.5459651574033e-05 1.24572462211419 0.512396694214876 10.1 10 1 sparse hair 2.16958388626718e-05 0.000687495530839441 1.24523456522115 0.51219512195122 10.1 10 1 abnormal mammary gland development 0.00241159816775971 0.0270218488391995 1.24523456522115 0.51219512195122 10.1 10 1 arrested B cell differentiation 0.00241159816775971 0.0270218488391995 1.24523456522115 0.51219512195122 10.1 10 1 palatal shelves fail to meet at midline 0.00241159816775971 0.0270218488391995 1.24523456522115 0.51219512195122 10.1 10 1 embryonic lethality before implantation, complete penetrance 1.79321767828182e-07 1.08795828651854e-05 1.24476019014868 0.512 10.1 10 1 oxidative stress 9.66817089404466e-06 0.000341128724807604 1.24259914815189 0.511111111111111 10.1 10 1 decreased osteoclast cell number 0.00158131453484053 0.0201203064215642 1.24259914815189 0.511111111111111 10.1 10 1 preweaning lethality, incomplete penetrance 6.34354491068187e-21 3.94489199133029e-18 1.24233496208872 0.511002444987775 10.1 10 1 reduced fertility 4.44609595254437e-08 3.25284225939827e-06 1.24182179491564 0.510791366906475 10.1 10 1 increased cellular sensitivity to gamma-irradiation 0.00128184193258074 0.0173095447453598 1.24144965772807 0.51063829787234 10.1 10 1 abnormal cell nucleus morphology 0.00128184193258074 0.0173095447453598 1.24144965772807 0.51063829787234 10.1 10 1 neuron degeneration 0.00128184193258074 0.0173095447453598 1.24144965772807 0.51063829787234 10.1 10 1 increased leukocyte cell number 2.44760685344897e-08 1.99620395014895e-06 1.24073618091329 0.510344827586207 10.1 10 1 absent kidney 0.00103974225567543 0.0149500512196107 1.24039400325721 0.510204081632653 10.1 10 1 increased fluid intake 0.00103974225567543 0.0149500512196107 1.24039400325721 0.510204081632653 10.1 10 1 increased monocyte cell number 3.5321290593481e-06 0.000147666740086191 1.23989784565591 0.51 10.1 10 1 respiratory failure 1.34794675937084e-08 1.2519927689048e-06 1.23973684087138 0.509933774834437 10.1 10 1 abnormal enzyme/coenzyme activity 7.42599257837654e-09 7.38886261548466e-07 1.23881388350784 0.509554140127389 10.1 10 1 increased sensitivity to xenobiotic induced morbidity/mortality 1.29442974989141e-06 6.17852733563221e-05 1.23768768906829 0.509090909090909 10.1 10 1 absent vitelline blood vessels 0.000452547649615028 0.00759980906431629 1.23691219552877 0.508771929824561 10.1 10 1 internal hemorrhage 0.000161567838894379 0.00339750616003518 1.23372919965762 0.507462686567164 10.1 10 1 decreased white adipose tissue amount 0.000161567838894379 0.00339750616003518 1.23372919965762 0.507462686567164 10.1 10 1 thymus hypoplasia 7.88225239625842e-08 5.29921698261968e-06 1.23320331338326 0.507246376811594 10.1 10 1 decreased bone marrow cell number 8.74453500245883e-05 0.00211961095075791 1.23223798789333 0.506849315068493 10.1 10 1 abnormal neural tube closure 3.15993211758034e-05 0.000930216703252202 1.23023173913414 0.506024096385542 10.1 10 1 increased grip strength 1.4051358901446e-05 0.000475547690712203 1.22894421245792 0.505494505494505 10.1 10 1 decreased B cell number 9.16957359543809e-11 1.30338938963727e-08 1.22738793021335 0.504854368932039 10.1 10 1 abnormal embryonic tissue morphology 5.11853342285172e-08 3.63781482552676e-06 1.22385541654712 0.503401360544218 10.1 10 1 abnormal brain morphology 1.26939954709956e-08 1.21447360515775e-06 1.22313634755972 0.503105590062112 10.1 10 1 abnormal abdominal fat pad morphology 0.0315171564673199 0.163988563317037 1.21558612319207 0.5 10.1 10 1 abnormal long bone epiphysis morphology 0.0315171564673199 0.163988563317037 1.21558612319207 0.5 10.1 10 1 abnormal tracheal cartilage morphology 0.0315171564673199 0.163988563317037 1.21558612319207 0.5 10.1 10 1 abnormal cochlear sensory epithelium morphology 0.0315171564673199 0.163988563317037 1.21558612319207 0.5 10.1 10 1 decreased susceptibility to viral infection induced morbidity/mortality 0.0315171564673199 0.163988563317037 1.21558612319207 0.5 10.1 10 1 increased circulating creatine kinase level 0.0315171564673199 0.163988563317037 1.21558612319207 0.5 10.1 10 1 increased mammary gland tumor incidence 0.0315171564673199 0.163988563317037 1.21558612319207 0.5 10.1 10 1 increased bone volume 0.0315171564673199 0.163988563317037 1.21558612319207 0.5 10.1 10 1 small gonad 0.0397056800744139 0.197141475419371 1.21558612319207 0.5 10.1 10 1 brain inflammation 0.0397056800744139 0.197141475419371 1.21558612319207 0.5 10.1 10 1 anencephaly 0.0397056800744139 0.197141475419371 1.21558612319207 0.5 10.1 10 1 abnormal trachea morphology 0.0397056800744139 0.197141475419371 1.21558612319207 0.5 10.1 10 1 decreased paired-pulse facilitation 0.0397056800744139 0.197141475419371 1.21558612319207 0.5 10.1 10 1 abnormal hyoid bone morphology 0.0397056800744139 0.197141475419371 1.21558612319207 0.5 10.1 10 1 abnormal thymocyte activation 0.0397056800744139 0.197141475419371 1.21558612319207 0.5 10.1 10 1 abnormal heart right ventricle morphology 0.0397056800744139 0.197141475419371 1.21558612319207 0.5 10.1 10 1 dilated vasculature 0.0397056800744139 0.197141475419371 1.21558612319207 0.5 10.1 10 1 kidney atrophy 0.0397056800744139 0.197141475419371 1.21558612319207 0.5 10.1 10 1 abnormal auchene hair morphology 0.13595304749995 0.402359554617639 1.21558612319207 0.5 10.1 10 1 kidney hemorrhage 0.13595304749995 0.402359554617639 1.21558612319207 0.5 10.1 10 1 enlarged testis 0.13595304749995 0.402359554617639 1.21558612319207 0.5 10.1 10 1 abnormal prostate gland epithelium morphology 0.13595304749995 0.402359554617639 1.21558612319207 0.5 10.1 10 1 fused cornea and lens 0.13595304749995 0.402359554617639 1.21558612319207 0.5 10.1 10 1 absent trophoblast giant cells 0.13595304749995 0.402359554617639 1.21558612319207 0.5 10.1 10 1 abnormal mammary gland physiology 0.13595304749995 0.402359554617639 1.21558612319207 0.5 10.1 10 1 aneurysm 0.13595304749995 0.402359554617639 1.21558612319207 0.5 10.1 10 1 absent CD4-positive, alpha beta T cells 0.13595304749995 0.402359554617639 1.21558612319207 0.5 10.1 10 1 increased atrioventricular cushion size 0.13595304749995 0.402359554617639 1.21558612319207 0.5 10.1 10 1 abnormal hindlimb zeugopod morphology 0.13595304749995 0.402359554617639 1.21558612319207 0.5 10.1 10 1 abnormal ear physiology 0.13595304749995 0.402359554617639 1.21558612319207 0.5 10.1 10 1 abnormal plasma membrane morphology 0.13595304749995 0.402359554617639 1.21558612319207 0.5 10.1 10 1 abnormal embryonic erythrocyte morphology 0.13595304749995 0.402359554617639 1.21558612319207 0.5 10.1 10 1 decreased cochlear inner hair cell number 0.13595304749995 0.402359554617639 1.21558612319207 0.5 10.1 10 1 abnormal corneal endothelium morphology 0.13595304749995 0.402359554617639 1.21558612319207 0.5 10.1 10 1 tachypnea 0.13595304749995 0.402359554617639 1.21558612319207 0.5 10.1 10 1 vascular smooth muscle hyperplasia 0.13595304749995 0.402359554617639 1.21558612319207 0.5 10.1 10 1 abnormal developmental vascular remodeling 0.13595304749995 0.402359554617639 1.21558612319207 0.5 10.1 10 1 protruding tongue 0.13595304749995 0.402359554617639 1.21558612319207 0.5 10.1 10 1 increased circulating fructosamine level 0.13595304749995 0.402359554617639 1.21558612319207 0.5 10.1 10 1 abnormal vibrissa follicle morphology 0.13595304749995 0.402359554617639 1.21558612319207 0.5 10.1 10 1 decreased circulating lactate level 0.13595304749995 0.402359554617639 1.21558612319207 0.5 10.1 10 1 increased fatty acid oxidation 0.13595304749995 0.402359554617639 1.21558612319207 0.5 10.1 10 1 impaired balance 7.35536772477337e-06 0.000265166336454692 1.21558612319207 0.5 10.1 10 1 abnormal locomotor behavior 2.02002896773509e-05 0.0006483641364182 1.21558612319207 0.5 10.1 10 1 increased oxygen consumption 3.71148162442795e-05 0.00104710807443829 1.21558612319207 0.5 10.1 10 1 increased circulating creatinine level 3.71148162442795e-05 0.00104710807443829 1.21558612319207 0.5 10.1 10 1 small liver 8.37773109133526e-05 0.00205316316154645 1.21558612319207 0.5 10.1 10 1 pale liver 0.000126060300250186 0.00286369860157385 1.21558612319207 0.5 10.1 10 1 decreased circulating LDL cholesterol level 0.000352025696302474 0.00618843759400992 1.21558612319207 0.5 10.1 10 1 prenatal lethality 0.000432760608156552 0.00732307491693485 1.21558612319207 0.5 10.1 10 1 increased erythrocyte cell number 0.000532234794960687 0.00869242098465123 1.21558612319207 0.5 10.1 10 1 enhanced long term potentiation 0.000806141840023162 0.0123023179574087 1.21558612319207 0.5 10.1 10 1 impaired limb coordination 0.000992870621260238 0.0144854291518172 1.21558612319207 0.5 10.1 10 1 distended pericardium 0.00122352683062273 0.0169555598394097 1.21558612319207 0.5 10.1 10 1 abnormal skin condition 0.00122352683062273 0.0169555598394097 1.21558612319207 0.5 10.1 10 1 increased susceptibility to injury 0.00122352683062273 0.0169555598394097 1.21558612319207 0.5 10.1 10 1 vertebral transformation 0.00186144395765804 0.0225867948071115 1.21558612319207 0.5 10.1 10 1 increased grooming behavior 0.00538565290279328 0.0488934729770011 1.21558612319207 0.5 10.1 10 1 abnormal lumbar vertebrae morphology 0.0103152987165396 0.0743747987170789 1.21558612319207 0.5 10.1 10 1 abnormal depression-related behavior 0.0103152987165396 0.0743747987170789 1.21558612319207 0.5 10.1 10 1 decreased susceptibility to parasitic infection 0.0103152987165396 0.0743747987170789 1.21558612319207 0.5 10.1 10 1 abnormal auditory brainstem response waveform shape 0.0103152987165396 0.0743747987170789 1.21558612319207 0.5 10.1 10 1 gastrointestinal hemorrhage 0.0128464545680624 0.0890114266836787 1.21558612319207 0.5 10.1 10 1 increased metastatic potential 0.0128464545680624 0.0890114266836787 1.21558612319207 0.5 10.1 10 1 abnormal spleen marginal zone morphology 0.0128464545680624 0.0890114266836787 1.21558612319207 0.5 10.1 10 1 abnormal brain vasculature morphology 0.0128464545680624 0.0890114266836787 1.21558612319207 0.5 10.1 10 1 rib bifurcation 0.016026012686907 0.105462186663178 1.21558612319207 0.5 10.1 10 1 abnormal hormone level 0.016026012686907 0.105462186663178 1.21558612319207 0.5 10.1 10 1 increased bone resorption 0.016026012686907 0.105462186663178 1.21558612319207 0.5 10.1 10 1 decreased circulating progesterone level 0.016026012686907 0.105462186663178 1.21558612319207 0.5 10.1 10 1 corneal vascularization 0.016026012686907 0.105462186663178 1.21558612319207 0.5 10.1 10 1 abnormal kidney cortex morphology 0.0200313915292293 0.124259567154509 1.21558612319207 0.5 10.1 10 1 thick skin 0.0200313915292293 0.124259567154509 1.21558612319207 0.5 10.1 10 1 decreased circulating glycerol level 0.0200313915292293 0.124259567154509 1.21558612319207 0.5 10.1 10 1 pulmonary edema 0.0200313915292293 0.124259567154509 1.21558612319207 0.5 10.1 10 1 decreased Peyer's patch number 0.0200313915292293 0.124259567154509 1.21558612319207 0.5 10.1 10 1 blindness 0.0250937792072342 0.14259747171786 1.21558612319207 0.5 10.1 10 1 abnormal thyroid cartilage morphology 0.0502042291624615 0.232710507300576 1.21558612319207 0.5 10.1 10 1 abnormal metacarpal bone morphology 0.0502042291624615 0.232710507300576 1.21558612319207 0.5 10.1 10 1 darkened coat color 0.0502042291624615 0.232710507300576 1.21558612319207 0.5 10.1 10 1 decreased pulmonary respiratory rate 0.0502042291624615 0.232710507300576 1.21558612319207 0.5 10.1 10 1 increased effector memory CD8-positive, alpha-beta T cell number 0.0502042291624615 0.232710507300576 1.21558612319207 0.5 10.1 10 1 increased adipocyte glucose uptake 0.0502042291624615 0.232710507300576 1.21558612319207 0.5 10.1 10 1 failure of tooth eruption 0.063760598925738 0.266120168205467 1.21558612319207 0.5 10.1 10 1 abnormal mouth morphology 0.063760598925738 0.266120168205467 1.21558612319207 0.5 10.1 10 1 poor circulation 0.063760598925738 0.266120168205467 1.21558612319207 0.5 10.1 10 1 increased intestinal adenocarcinoma incidence 0.063760598925738 0.266120168205467 1.21558612319207 0.5 10.1 10 1 bowed radius 0.063760598925738 0.266120168205467 1.21558612319207 0.5 10.1 10 1 increased cochlear outer hair cell number 0.063760598925738 0.266120168205467 1.21558612319207 0.5 10.1 10 1 small epididymis 0.063760598925738 0.266120168205467 1.21558612319207 0.5 10.1 10 1 abnormal level of surface class II molecules 0.063760598925738 0.266120168205467 1.21558612319207 0.5 10.1 10 1 dystonia 0.063760598925738 0.266120168205467 1.21558612319207 0.5 10.1 10 1 abnormal intestinal lipid absorption 0.063760598925738 0.266120168205467 1.21558612319207 0.5 10.1 10 1 loose skin 0.063760598925738 0.266120168205467 1.21558612319207 0.5 10.1 10 1 decreased liver cholesterol level 0.063760598925738 0.266120168205467 1.21558612319207 0.5 10.1 10 1 abnormal thoracic cage shape 0.063760598925738 0.266120168205467 1.21558612319207 0.5 10.1 10 1 dilated respiratory conducting tubes 0.063760598925738 0.266120168205467 1.21558612319207 0.5 10.1 10 1 abnormal pulmonary alveolus wall morphology 0.063760598925738 0.266120168205467 1.21558612319207 0.5 10.1 10 1 absent atrioventricular cushions 0.0814252638090616 0.290611309859591 1.21558612319207 0.5 10.1 10 1 abnormal adrenal gland secretion 0.0814252638090616 0.290611309859591 1.21558612319207 0.5 10.1 10 1 abnormal fluid regulation 0.0814252638090616 0.290611309859591 1.21558612319207 0.5 10.1 10 1 abnormal prepulse inhibition 0.0814252638090616 0.290611309859591 1.21558612319207 0.5 10.1 10 1 absent olfactory bulb 0.0814252638090616 0.290611309859591 1.21558612319207 0.5 10.1 10 1 abnormal voluntary movement 0.0814252638090616 0.290611309859591 1.21558612319207 0.5 10.1 10 1 abnormal vascular endothelial cell migration 0.0814252638090616 0.290611309859591 1.21558612319207 0.5 10.1 10 1 abnormal decidualization 0.0814252638090616 0.290611309859591 1.21558612319207 0.5 10.1 10 1 skeletal muscle necrosis 0.0814252638090616 0.290611309859591 1.21558612319207 0.5 10.1 10 1 abnormal maternal decidual layer morphology 0.0814252638090616 0.290611309859591 1.21558612319207 0.5 10.1 10 1 abnormal positive T cell selection 0.0814252638090616 0.290611309859591 1.21558612319207 0.5 10.1 10 1 increased circulating growth hormone level 0.0814252638090616 0.290611309859591 1.21558612319207 0.5 10.1 10 1 increased pulmonary respiratory rate 0.0814252638090616 0.290611309859591 1.21558612319207 0.5 10.1 10 1 increased stomach tumor incidence 0.0814252638090616 0.290611309859591 1.21558612319207 0.5 10.1 10 1 abnormal vitelline vein topology 0.0814252638090616 0.290611309859591 1.21558612319207 0.5 10.1 10 1 abnormal rectum morphology 0.104720894198504 0.338083354080179 1.21558612319207 0.5 10.1 10 1 amyloidosis 0.104720894198504 0.338083354080179 1.21558612319207 0.5 10.1 10 1 mesocardia 0.104720894198504 0.338083354080179 1.21558612319207 0.5 10.1 10 1 abnormal superior cervical ganglion morphology 0.104720894198504 0.338083354080179 1.21558612319207 0.5 10.1 10 1 abnormal enteric nervous system morphology 0.104720894198504 0.338083354080179 1.21558612319207 0.5 10.1 10 1 increased circulating parathyroid hormone level 0.104720894198504 0.338083354080179 1.21558612319207 0.5 10.1 10 1 increased fear-related response 0.104720894198504 0.338083354080179 1.21558612319207 0.5 10.1 10 1 delayed somite formation 0.104720894198504 0.338083354080179 1.21558612319207 0.5 10.1 10 1 abnormal rostral-caudal body axis extension 0.104720894198504 0.338083354080179 1.21558612319207 0.5 10.1 10 1 vestibular saccular macula degeneration 0.104720894198504 0.338083354080179 1.21558612319207 0.5 10.1 10 1 bowed ulna 0.104720894198504 0.338083354080179 1.21558612319207 0.5 10.1 10 1 abnormal thymus corticomedullary boundary morphology 0.104720894198504 0.338083354080179 1.21558612319207 0.5 10.1 10 1 reduced cerebellar foliation 0.104720894198504 0.338083354080179 1.21558612319207 0.5 10.1 10 1 increased fibrosarcoma incidence 0.104720894198504 0.338083354080179 1.21558612319207 0.5 10.1 10 1 abnormal pulmonary valve cusp morphology 0.104720894198504 0.338083354080179 1.21558612319207 0.5 10.1 10 1 prenatal growth retardation 0.104720894198504 0.338083354080179 1.21558612319207 0.5 10.1 10 1 abnormal vitelline vein connection 0.104720894198504 0.338083354080179 1.21558612319207 0.5 10.1 10 1 preweaning lethality, complete penetrance 4.17847852965491e-33 1.03939653425166e-29 1.21230075529155 0.498648648648649 10.1 10 1 abnormal cell cycle 3.12718128733504e-06 0.000131845143258405 1.20501580907736 0.495652173913044 10.1 10 1 decreased IgM level 1.91724412545357e-05 0.000619369449618929 1.20305430748906 0.494845360824742 10.1 10 1 increased neuron apoptosis 9.72106657464301e-05 0.00228124085890797 1.20057888710328 0.493827160493827 10.1 10 1 abnormal somite development 0.000119201230362192 0.00272030330757754 1.20019895707572 0.493670886075949 10.1 10 1 embryonic growth arrest 8.95819052575421e-11 1.30338938963727e-08 1.19966141415462 0.493449781659389 10.1 10 1 abnormal epidermal layer morphology 0.000331870664370124 0.0058756461040618 1.19796893300088 0.492753623188406 10.1 10 1 increased lymphocyte cell number 0.000331870664370124 0.0058756461040618 1.19796893300088 0.492753623188406 10.1 10 1 rib fusion 0.000407689211988571 0.00699397872290739 1.19744304672652 0.492537313432836 10.1 10 1 increased tumor incidence 1.97735701890295e-06 8.92768383434098e-05 1.19597989539865 0.491935483870968 10.1 10 1 decreased embryo size 1.53434420554654e-20 7.63336242259402e-18 1.19524158556542 0.49163179916318 10.1 10 1 abnormal cell morphology 5.39151100773207e-06 0.000204753948576084 1.19426005085537 0.491228070175439 10.1 10 1 abnormal craniofacial bone morphology 0.00114754312731377 0.0161728811852295 1.19426005085537 0.491228070175439 10.1 10 1 abnormal embryo turning 0.00141342013823528 0.0182643251629104 1.19348455731585 0.490909090909091 10.1 10 1 abnormal coat/ hair morphology 0.00174185998061158 0.0217732497576448 1.19265053596203 0.490566037735849 10.1 10 1 abnormal dendritic spine morphology 0.00214789556594599 0.0247929940616736 1.1917511011687 0.490196078431373 10.1 10 1 abnormal respiratory system physiology 0.00265027759156133 0.0289147610044246 1.19077824312693 0.489795918367347 10.1 10 1 increased neutrophil cell number 3.75690954870222e-07 2.07673611164373e-05 1.19043606547086 0.489655172413793 10.1 10 1 decreased hemoglobin content 5.59864378566129e-07 2.99497342297472e-05 1.18972258865607 0.48936170212766 10.1 10 1 increased respiratory quotient 0.00327243173423764 0.0335677275831593 1.18972258865607 0.48936170212766 10.1 10 1 abnormal behavior 2.59529177212496e-12 5.37982356930069e-10 1.1893504514685 0.489208633093525 10.1 10 1 decreased leukocyte cell number 8.3454164222139e-07 4.19378249500143e-05 1.18896744896159 0.489051094890511 10.1 10 1 irregular heartbeat 0.00404367660932675 0.0392149924588705 1.18857309823225 0.488888888888889 10.1 10 1 abnormal left-right axis patterning 0.00500077933804703 0.0457348361029109 1.18731667846667 0.488372093023256 10.1 10 1 abnormal homeostasis 0.00500077933804703 0.0457348361029109 1.18731667846667 0.488372093023256 10.1 10 1 abnormal blood circulation 0.00500077933804703 0.0457348361029109 1.18731667846667 0.488372093023256 10.1 10 1 perinatal lethality, complete penetrance 1.0440203966648e-09 1.20790731939707e-07 1.18705123767113 0.488262910798122 10.1 10 1 decreased exploration in new environment 0.000111543792013314 0.0025810714663546 1.1866435964494 0.488095238095238 10.1 10 1 hyperactivity 9.59524213843292e-16 3.67202535682337e-13 1.18609751103916 0.487870619946092 10.1 10 1 Leydig cell hyperplasia 0.00618995073105037 0.0540263243631151 1.185937681163 0.48780487804878 10.1 10 1 abnormal heart ventricle morphology 0.000205511291791148 0.00390236136130139 1.18441724823843 0.487179487179487 10.1 10 1 decreased trabecular bone volume 0.0076694166810579 0.0618401101916743 1.18441724823843 0.487179487179487 10.1 10 1 small seminiferous tubules 0.000309264120328991 0.00553449280085155 1.18273244418688 0.486486486486487 10.1 10 1 abnormal long bone metaphysis morphology 0.00951275048055005 0.0706554586523516 1.18273244418688 0.486486486486487 10.1 10 1 increased erythroid progenitor cell number 0.00951275048055005 0.0706554586523516 1.18273244418688 0.486486486486487 10.1 10 1 abnormal hepatocyte morphology 1.12658831670276e-05 0.000388265067225845 1.18273244418688 0.486486486486487 10.1 10 1 lethality throughout fetal growth and development, incomplete penetrance 3.02845847115242e-08 2.39152077682274e-06 1.18163120354983 0.486033519553073 10.1 10 1 impaired behavioral response to xenobiotic 0.0118132186880741 0.0834811974050693 1.18085509110087 0.485714285714286 10.1 10 1 decreased bone mineralization 0.0118132186880741 0.0834811974050693 1.18085509110087 0.485714285714286 10.1 10 1 prenatal lethality, complete penetrance 6.11099578788134e-12 1.08579300159677e-09 1.18060522756064 0.485611510791367 10.1 10 1 decreased circulating alanine transaminase level 0.000572206778312935 0.0092127143110254 1.17983359015701 0.485294117647059 10.1 10 1 decreased mean corpuscular hemoglobin 0.000572206778312935 0.0092127143110254 1.17983359015701 0.485294117647059 10.1 10 1 cardiovascular system phenotype 0.0146894905267845 0.0988906838575817 1.17875018006504 0.484848484848485 10.1 10 1 abnormal heart morphology 4.13685548828166e-10 5.14521401355031e-08 1.17875018006504 0.484848484848485 10.1 10 1 abnormal object recognition memory 0.0182932029221146 0.115121720172546 1.17637366760523 0.483870967741935 10.1 10 1 decreased double-negative T cell number 0.0182932029221146 0.115121720172546 1.17637366760523 0.483870967741935 10.1 10 1 small cranium 0.0182932029221146 0.115121720172546 1.17637366760523 0.483870967741935 10.1 10 1 abnormal mitochondrial ATP synthesis coupled electron transport 0.0182932029221146 0.115121720172546 1.17637366760523 0.483870967741935 10.1 10 1 decreased heart weight 0.000232954638280723 0.00437339368093056 1.1705644149257 0.481481481481481 10.1 10 1 abnormal cochlea morphology 0.00243735010000927 0.0272069752481306 1.1705644149257 0.481481481481481 10.1 10 1 abnormal fetal cardiomyocyte proliferation 0.0285186691116327 0.150936573223801 1.1705644149257 0.481481481481481 10.1 10 1 abnormal eye muscle morphology 0.0285186691116327 0.150936573223801 1.1705644149257 0.481481481481481 10.1 10 1 abnormal skin appearance 0.0285186691116327 0.150936573223801 1.1705644149257 0.481481481481481 10.1 10 1 decreased circulating fructosamine level 0.0285186691116327 0.150936573223801 1.1705644149257 0.481481481481481 10.1 10 1 abnormal cardiovascular system physiology 2.92099529372471e-06 0.000124204714412653 1.16988739675628 0.481203007518797 10.1 10 1 decreased cell proliferation 3.88810350535851e-08 2.93080529381191e-06 1.1695909725848 0.481081081081081 10.1 10 1 absent corpus luteum 0.00300379254309715 0.0319997171347074 1.16883281076161 0.480769230769231 10.1 10 1 abnormal hair growth 0.00300379254309715 0.0319997171347074 1.16883281076161 0.480769230769231 10.1 10 1 prenatal lethality, incomplete penetrance 2.52283124295807e-12 5.37982356930069e-10 1.16760246043449 0.480263157894737 10.1 10 1 abnormal liver physiology 5.20905352695972e-05 0.00140842615742525 1.16696267826439 0.48 10.1 10 1 abnormal hindlimb morphology 0.00370407513643446 0.0364906411955672 1.16696267826439 0.48 10.1 10 1 spontaneous skin ulceration 0.0357191200466055 0.179860953675974 1.16696267826439 0.48 10.1 10 1 abnormal keratinocyte physiology 0.0357191200466055 0.179860953675974 1.16696267826439 0.48 10.1 10 1 small heart 0.00457054048869089 0.0430431607251859 1.1649367013924 0.479166666666667 10.1 10 1 thymus atrophy 0.00457054048869089 0.0430431607251859 1.1649367013924 0.479166666666667 10.1 10 1 decreased T cell number 4.16886826329721e-07 2.27913402306633e-05 1.1627345526185 0.478260869565217 10.1 10 1 abnormal blood vessel physiology 0.0448495326664238 0.213722629325152 1.1627345526185 0.478260869565217 10.1 10 1 conjunctivitis 0.0448495326664238 0.213722629325152 1.1627345526185 0.478260869565217 10.1 10 1 abnormal cardiovascular development 0.0448495326664238 0.213722629325152 1.1627345526185 0.478260869565217 10.1 10 1 abnormal hepatocyte physiology 0.0448495326664238 0.213722629325152 1.1627345526185 0.478260869565217 10.1 10 1 hypertension 0.00697379707433041 0.0585069822003268 1.16033220850152 0.477272727272727 10.1 10 1 abnormal circadian rhythm 0.00697379707433041 0.0585069822003268 1.16033220850152 0.477272727272727 10.1 10 1 abnormal lipid homeostasis 5.96447423595755e-06 0.000221442233760364 1.15948214827551 0.476923076923077 10.1 10 1 infertility 3.91348892441795e-05 0.00109379816848198 1.15878303332328 0.476635514018692 10.1 10 1 disheveled coat 0.00862455631658105 0.0674641001179099 1.15770106970673 0.476190476190476 10.1 10 1 small ears 0.0564784099525713 0.247777856714323 1.15770106970673 0.476190476190476 10.1 10 1 abnormal hematopoietic system physiology 0.0564784099525713 0.247777856714323 1.15770106970673 0.476190476190476 10.1 10 1 increased incidence of induced tumors 0.0564784099525713 0.247777856714323 1.15770106970673 0.476190476190476 10.1 10 1 abnormal clavicle morphology 0.0564784099525713 0.247777856714323 1.15770106970673 0.476190476190476 10.1 10 1 complete atrioventricular septal defect 0.0564784099525713 0.247777856714323 1.15770106970673 0.476190476190476 10.1 10 1 increased bone ossification 0.0564784099525713 0.247777856714323 1.15770106970673 0.476190476190476 10.1 10 1 increased muscle cell glucose uptake 0.0564784099525713 0.247777856714323 1.15770106970673 0.476190476190476 10.1 10 1 gliosis 0.00146763116291437 0.0188182088543788 1.15770106970673 0.476190476190476 10.1 10 1 abnormal NK cell physiology 0.00180355706432558 0.022156544258372 1.15580319910066 0.475409836065574 10.1 10 1 abnormal pulmonary alveolus morphology 7.13711791224419e-05 0.00180239399052867 1.15540859234098 0.475247524752475 10.1 10 1 abnormal kidney morphology 2.36975310371923e-07 1.38700255188272e-05 1.15307026542791 0.474285714285714 10.1 10 1 abnormal reproductive system physiology 0.0132271383005311 0.0912690888282139 1.15160790618196 0.473684210526316 10.1 10 1 abnormal compact bone morphology 0.0132271383005311 0.0912690888282139 1.15160790618196 0.473684210526316 10.1 10 1 abnormal triglyceride level 0.0713684102408421 0.288899789217404 1.15160790618196 0.473684210526316 10.1 10 1 irregular coat pigmentation 0.0713684102408421 0.288899789217404 1.15160790618196 0.473684210526316 10.1 10 1 enlarged adrenal glands 0.0713684102408421 0.288899789217404 1.15160790618196 0.473684210526316 10.1 10 1 altered susceptibility to infection 0.0713684102408421 0.288899789217404 1.15160790618196 0.473684210526316 10.1 10 1 delayed sexual maturation 0.0713684102408421 0.288899789217404 1.15160790618196 0.473684210526316 10.1 10 1 abnormal metatarsal bone morphology 0.0713684102408421 0.288899789217404 1.15160790618196 0.473684210526316 10.1 10 1 abnormal response to novelty 0.0713684102408421 0.288899789217404 1.15160790618196 0.473684210526316 10.1 10 1 oliguria 0.0713684102408421 0.288899789217404 1.15160790618196 0.473684210526316 10.1 10 1 decreased eye pigmentation 0.0713684102408421 0.288899789217404 1.15160790618196 0.473684210526316 10.1 10 1 abnormal behavioral response to xenobiotic 0.0713684102408421 0.288899789217404 1.15160790618196 0.473684210526316 10.1 10 1 increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 0.0713684102408421 0.288899789217404 1.15160790618196 0.473684210526316 10.1 10 1 decreased susceptibility to weight gain 0.0713684102408421 0.288899789217404 1.15160790618196 0.473684210526316 10.1 10 1 kidney cysts 0.000721210946720004 0.0111084348604707 1.14987876518169 0.472972972972973 10.1 10 1 small spleen 0.000194711989417804 0.00381280768369066 1.14879567686284 0.472527472527473 10.1 10 1 small ovary 0.000194711989417804 0.00381280768369066 1.14879567686284 0.472527472527473 10.1 10 1 decreased body size 7.79132400308012e-28 7.75236738306472e-25 1.14856132441958 0.472431077694236 10.1 10 1 abnormal uterus morphology 0.0164061188671816 0.107113440110536 1.14805356079251 0.472222222222222 10.1 10 1 short radius 0.0164061188671816 0.107113440110536 1.14805356079251 0.472222222222222 10.1 10 1 head tilt 0.0164061188671816 0.107113440110536 1.14805356079251 0.472222222222222 10.1 10 1 narrow eye opening 0.0164061188671816 0.107113440110536 1.14805356079251 0.472222222222222 10.1 10 1 premature death 1.10778293169586e-29 1.37780502129673e-26 1.14640642512423 0.471544715447154 10.1 10 1 abnormal extraembryonic tissue morphology 9.69428223385036e-05 0.00228124085890797 1.14408105712195 0.470588235294118 10.1 10 1 cochlear inner hair cell degeneration 0.00508734586575755 0.0462697361647967 1.14408105712195 0.470588235294118 10.1 10 1 decreased susceptibility to injury 0.00132905621354146 0.0174391300307673 1.14408105712195 0.470588235294118 10.1 10 1 abnormal endoderm development 0.0203731477420871 0.126065186588163 1.14408105712195 0.470588235294118 10.1 10 1 hydroureter 0.0905587816724755 0.300153190420097 1.14408105712195 0.470588235294118 10.1 10 1 distended urinary bladder 0.0905587816724755 0.300153190420097 1.14408105712195 0.470588235294118 10.1 10 1 abnormal touch/ nociception 0.0905587816724755 0.300153190420097 1.14408105712195 0.470588235294118 10.1 10 1 increased hepatoma incidence 0.0905587816724755 0.300153190420097 1.14408105712195 0.470588235294118 10.1 10 1 abnormal survival 0.0905587816724755 0.300153190420097 1.14408105712195 0.470588235294118 10.1 10 1 delayed heart development 0.0905587816724755 0.300153190420097 1.14408105712195 0.470588235294118 10.1 10 1 postnatal lethality 8.55965823945393e-07 4.25842997412833e-05 1.1423580434817 0.469879518072289 10.1 10 1 abnormal nervous system physiology 3.96736223977735e-05 0.0011026607342398 1.14159392438907 0.469565217391304 10.1 10 1 abnormal long bone hypertrophic chondrocyte zone 0.0062692345899978 0.0545269966525158 1.14116248299664 0.469387755102041 10.1 10 1 abnormal craniofacial development 0.0062692345899978 0.0545269966525158 1.14116248299664 0.469387755102041 10.1 10 1 increased exploration in new environment 0.000532902191018819 0.00869242098465123 1.14054994274812 0.469135802469136 10.1 10 1 abnormal osteoclast physiology 0.00200035782008852 0.0238080864950726 1.13961199049257 0.46875 10.1 10 1 kidney cortex cysts 0.0253325301623278 0.14259747171786 1.13961199049257 0.46875 10.1 10 1 polydipsia 0.0253325301623278 0.14259747171786 1.13961199049257 0.46875 10.1 10 1 failure of primitive streak formation 0.0253325301623278 0.14259747171786 1.13961199049257 0.46875 10.1 10 1 increased circulating follicle stimulating hormone level 0.0253325301623278 0.14259747171786 1.13961199049257 0.46875 10.1 10 1 abnormal lymphatic vessel morphology 0.0253325301623278 0.14259747171786 1.13961199049257 0.46875 10.1 10 1 neonatal lethality 0.0253325301623278 0.14259747171786 1.13961199049257 0.46875 10.1 10 1 abnormal heart atrium morphology 0.0253325301623278 0.14259747171786 1.13961199049257 0.46875 10.1 10 1 decreased IgG level 5.90041998406317e-05 0.0015288848656622 1.13892753884662 0.468468468468468 10.1 10 1 hunched posture 0.000652063043462028 0.0102334815180555 1.13865029261029 0.468354430379747 10.1 10 1 abnormal visceral yolk sac morphology 0.000652063043462028 0.0102334815180555 1.13865029261029 0.468354430379747 10.1 10 1 cleft secondary palate 0.000215557491762197 0.00407756091831532 1.13799551958407 0.468085106382979 10.1 10 1 abnormal T-helper 1 physiology 0.00773021483353946 0.0622294802538169 1.13799551958407 0.468085106382979 10.1 10 1 increased bone mineral content 7.1961164928025e-05 0.00180811512887335 1.13752095931735 0.467889908256881 10.1 10 1 pericardial effusion 0.00245516904128164 0.0273254272491637 1.13716121201839 0.467741935483871 10.1 10 1 double outlet right ventricle 8.7766805197212e-05 0.00211961095075791 1.13606179737577 0.467289719626168 10.1 10 1 increased susceptibility to parasitic infection 0.000321589848734617 0.00573444264320688 1.1345470483126 0.466666666666667 10.1 10 1 abnormal hair cycle 0.0315451367023928 0.163988563317037 1.1345470483126 0.466666666666667 10.1 10 1 disorganized myocardium 0.0315451367023928 0.163988563317037 1.1345470483126 0.466666666666667 10.1 10 1 abnormal enteric neuron morphology 0.115494246605314 0.356662865835777 1.1345470483126 0.466666666666667 10.1 10 1 abnormal epidermis stratum spinosum morphology 0.115494246605314 0.356662865835777 1.1345470483126 0.466666666666667 10.1 10 1 no suckling reflex 0.115494246605314 0.356662865835777 1.1345470483126 0.466666666666667 10.1 10 1 immune system phenotype 0.115494246605314 0.356662865835777 1.1345470483126 0.466666666666667 10.1 10 1 abnormal cerebral aqueduct morphology 0.115494246605314 0.356662865835777 1.1345470483126 0.466666666666667 10.1 10 1 abnormal Muller cell morphology 0.115494246605314 0.356662865835777 1.1345470483126 0.466666666666667 10.1 10 1 decreased thymocyte apoptosis 0.115494246605314 0.356662865835777 1.1345470483126 0.466666666666667 10.1 10 1 lactation failure 0.115494246605314 0.356662865835777 1.1345470483126 0.466666666666667 10.1 10 1 ostium primum atrial septal defect 0.115494246605314 0.356662865835777 1.1345470483126 0.466666666666667 10.1 10 1 decreased brown adipose tissue mass 0.115494246605314 0.356662865835777 1.1345470483126 0.466666666666667 10.1 10 1 small kidney 0.000392852391737719 0.00678625225310817 1.13270525115625 0.465909090909091 10.1 10 1 abnormal fertility/fecundity 0.00119576321354311 0.0168048643711214 1.13232679968576 0.465753424657534 10.1 10 1 ataxia 1.21556512643311e-07 7.8538136415646e-06 1.13133758000054 0.465346534653465 10.1 10 1 decreased body weight 1.1073748868689e-39 5.50919006217278e-36 1.13114314532897 0.465266558966074 10.1 10 1 embryonic lethality during organogenesis, incomplete penetrance 1.73477610914013e-08 1.46279849880884e-06 1.13102361027436 0.465217391304348 10.1 10 1 decreased oxygen consumption 0.0117756667326976 0.0834529088250291 1.13077778901588 0.465116279069767 10.1 10 1 abnormal ovary morphology 0.00146414180755129 0.0188182088543788 1.12998146662925 0.464788732394366 10.1 10 1 atelectasis 0.00146414180755129 0.0188182088543788 1.12998146662925 0.464788732394366 10.1 10 1 abnormal coat/hair pigmentation 7.91466965963053e-05 0.00194928126518128 1.12875854296407 0.464285714285714 10.1 10 1 increased triglyceride level 0.0393456380130616 0.197141475419371 1.12875854296407 0.464285714285714 10.1 10 1 hemorrhage 1.5685020094157e-08 1.3492361242088e-06 1.12765010576967 0.463829787234043 10.1 10 1 abnormal sternum morphology 0.00179309195908175 0.022156544258372 1.12750017223612 0.463768115942029 10.1 10 1 microcephaly 0.00179309195908175 0.022156544258372 1.12750017223612 0.463768115942029 10.1 10 1 short humerus 0.01454947049742 0.0983473039737292 1.12664079710485 0.463414634146341 10.1 10 1 abnormal embryo development 1.6197124737028e-05 0.000540810037360498 1.12620479060442 0.463235294117647 10.1 10 1 abnormal maxilla morphology 0.00559014558437426 0.0502910927346509 1.12554270665932 0.462962962962963 10.1 10 1 abnormal small intestine morphology 0.00559014558437426 0.0502910927346509 1.12554270665932 0.462962962962963 10.1 10 1 decreased compact bone thickness 0.00219637588957852 0.0252939121542897 1.1248707408643 0.462686567164179 10.1 10 1 decreased startle reflex 7.11287716608149e-05 0.00180239399052867 1.12207949833114 0.461538461538462 10.1 10 1 increased autoantibody level 0.017990899688651 0.114309994828913 1.12207949833114 0.461538461538462 10.1 10 1 eyelids open at birth 0.00687324871375214 0.057858565737592 1.12207949833114 0.461538461538462 10.1 10 1 kinked neural tube 0.00687324871375214 0.057858565737592 1.12207949833114 0.461538461538462 10.1 10 1 abnormal nasal bone morphology 0.0491657444900707 0.230319754084842 1.12207949833114 0.461538461538462 10.1 10 1 no spontaneous movement 0.0491657444900707 0.230319754084842 1.12207949833114 0.461538461538462 10.1 10 1 short hair 0.148236269440123 0.431184017374584 1.12207949833114 0.461538461538462 10.1 10 1 tight skin 0.148236269440123 0.431184017374584 1.12207949833114 0.461538461538462 10.1 10 1 pup cannibalization 0.148236269440123 0.431184017374584 1.12207949833114 0.461538461538462 10.1 10 1 abnormal intercostal muscle morphology 0.148236269440123 0.431184017374584 1.12207949833114 0.461538461538462 10.1 10 1 abnormal tail bud morphology 0.148236269440123 0.431184017374584 1.12207949833114 0.461538461538462 10.1 10 1 increased synaptic depression 0.148236269440123 0.431184017374584 1.12207949833114 0.461538461538462 10.1 10 1 vestibular hair cell degeneration 0.148236269440123 0.431184017374584 1.12207949833114 0.461538461538462 10.1 10 1 increased cochlear inner hair cell number 0.148236269440123 0.431184017374584 1.12207949833114 0.461538461538462 10.1 10 1 increased circulating thyroid-stimulating hormone level 0.148236269440123 0.431184017374584 1.12207949833114 0.461538461538462 10.1 10 1 abnormal vertebral arch development 0.148236269440123 0.431184017374584 1.12207949833114 0.461538461538462 10.1 10 1 increased circulating ammonia level 0.148236269440123 0.431184017374584 1.12207949833114 0.461538461538462 10.1 10 1 small pituitary gland 0.148236269440123 0.431184017374584 1.12207949833114 0.461538461538462 10.1 10 1 increased circulating thyroxine level 0.148236269440123 0.431184017374584 1.12207949833114 0.461538461538462 10.1 10 1 increased renin activity 0.148236269440123 0.431184017374584 1.12207949833114 0.461538461538462 10.1 10 1 orthokeratosis 0.148236269440123 0.431184017374584 1.12207949833114 0.461538461538462 10.1 10 1 empty decidua capsularis 0.148236269440123 0.431184017374584 1.12207949833114 0.461538461538462 10.1 10 1 abnormal aorta tunica media morphology 0.148236269440123 0.431184017374584 1.12207949833114 0.461538461538462 10.1 10 1 abnormal bone structure 4.26132594317154e-07 2.30435832253026e-05 1.12111051776263 0.461139896373057 10.1 10 1 abnormal skeleton morphology 8.65747855237279e-05 0.00211132136264974 1.12045329615965 0.460869565217391 10.1 10 1 neonatal lethality, complete penetrance 1.16785206910139e-14 3.63129002736214e-12 1.11961879767691 0.460526315789474 10.1 10 1 perinatal lethality, incomplete penetrance 5.46022743643905e-08 3.77286548559504e-06 1.11876952930952 0.460176991150442 10.1 10 1 decreased double-positive T cell number 0.000258950431822433 0.00478913902719928 1.11833923333671 0.46 10.1 10 1 kidney inflammation 0.00845437042081096 0.0664462762141146 1.11833923333671 0.46 10.1 10 1 short limbs 0.000640633201069365 0.0101179370645082 1.11778034316512 0.459770114942529 10.1 10 1 abnormal angiogenesis 0.00159913264034276 0.0201409743941904 1.1170250861765 0.459459459459459 10.1 10 1 abnormal intestine morphology 0.00159913264034276 0.0201409743941904 1.1170250861765 0.459459459459459 10.1 10 1 increased white adipose tissue amount 0.0222654819958184 0.132659608298439 1.1170250861765 0.459459459459459 10.1 10 1 impaired skeletal muscle contractility 0.0222654819958184 0.132659608298439 1.1170250861765 0.459459459459459 10.1 10 1 increased double-negative T cell number 0.00404166806703 0.0392149924588705 1.11594791637305 0.459016393442623 10.1 10 1 cardiac fibrosis 0.000781685431241539 0.0119658000628513 1.1154790306939 0.458823529411765 10.1 10 1 decreased circulating glucose level 2.17232111852216e-09 2.34941251405385e-07 1.11537651447014 0.458781362007168 10.1 10 1 curly tail 0.0104037854330266 0.0748238288091415 1.11428727959273 0.458333333333333 10.1 10 1 abnormal malleus morphology 0.061565939439584 0.266120168205467 1.11428727959273 0.458333333333333 10.1 10 1 abnormal startle reflex 0.061565939439584 0.266120168205467 1.11428727959273 0.458333333333333 10.1 10 1 decreased ovulation rate 0.061565939439584 0.266120168205467 1.11428727959273 0.458333333333333 10.1 10 1 abnormal osteoblast morphology 0.061565939439584 0.266120168205467 1.11428727959273 0.458333333333333 10.1 10 1 hypopigmentation 0.061565939439584 0.266120168205467 1.11428727959273 0.458333333333333 10.1 10 1 increased circulating total protein level 0.061565939439584 0.266120168205467 1.11428727959273 0.458333333333333 10.1 10 1 impaired fertilization 0.00239040961768362 0.0270218488391995 1.11139302691846 0.457142857142857 10.1 10 1 domed cranium 0.00239040961768362 0.0270218488391995 1.11139302691846 0.457142857142857 10.1 10 1 abnormal action potential 0.00239040961768362 0.0270218488391995 1.11139302691846 0.457142857142857 10.1 10 1 abnormal intestinal goblet cell morphology 0.0275815090507297 0.147142875886656 1.11139302691846 0.457142857142857 10.1 10 1 decreased glycogen level 0.0275815090507297 0.147142875886656 1.11139302691846 0.457142857142857 10.1 10 1 abnormal neural tube morphology 5.85442698549978e-06 0.000218990783856101 1.11053547057053 0.45679012345679 10.1 10 1 abnormal spermatogenesis 1.47455345463966e-06 6.85598452040402e-05 1.10988298204493 0.456521739130435 10.1 10 1 atrial septal defect 0.0128086624813166 0.0890114266836787 1.10988298204493 0.456521739130435 10.1 10 1 seizures 0.000139266932430359 0.00305060341147461 1.10895576150856 0.456140350877193 10.1 10 1 incomplete embryo turning 0.00607597676602115 0.0531247529190777 1.10895576150856 0.456140350877193 10.1 10 1 impaired natural killer cell mediated cytotoxicity 0.00607597676602115 0.0531247529190777 1.10895576150856 0.456140350877193 10.1 10 1 ventricular septal defect 3.44652328772315e-05 0.00099688682304783 1.10832852408689 0.455882352941176 10.1 10 1 impaired glucose tolerance 2.91445173700763e-08 2.33861248251822e-06 1.10775187032826 0.455645161290323 10.1 10 1 thin ventricular wall 0.000695297996390664 0.0108097110376361 1.10753402335278 0.455555555555556 10.1 10 1 increased blood urea nitrogen level 2.08781861976565e-05 0.000665826771367572 1.10660253973347 0.455172413793103 10.1 10 1 abnormal contextual conditioning behavior 0.0074524700108243 0.060286241144473 1.10507829381097 0.454545454545455 10.1 10 1 osteoporosis 0.015777224781337 0.104516236068111 1.10507829381097 0.454545454545455 10.1 10 1 omphalocele 0.015777224781337 0.104516236068111 1.10507829381097 0.454545454545455 10.1 10 1 decreased macrophage cell number 0.015777224781337 0.104516236068111 1.10507829381097 0.454545454545455 10.1 10 1 abnormal amino acid level 0.015777224781337 0.104516236068111 1.10507829381097 0.454545454545455 10.1 10 1 decreased sensitivity to induced morbidity/mortality 0.015777224781337 0.104516236068111 1.10507829381097 0.454545454545455 10.1 10 1 head tossing 0.0342017298586139 0.172920331348175 1.10507829381097 0.454545454545455 10.1 10 1 decreased sensitivity to xenobiotic induced morbidity/mortality 0.0342017298586139 0.172920331348175 1.10507829381097 0.454545454545455 10.1 10 1 myeloid hyperplasia 0.0342017298586139 0.172920331348175 1.10507829381097 0.454545454545455 10.1 10 1 intestinal ulcer 0.0772794545236145 0.290611309859591 1.10507829381097 0.454545454545455 10.1 10 1 abnormal oogenesis 0.0772794545236145 0.290611309859591 1.10507829381097 0.454545454545455 10.1 10 1 abnormal chorion morphology 0.0772794545236145 0.290611309859591 1.10507829381097 0.454545454545455 10.1 10 1 prolonged PR interval 0.0772794545236145 0.290611309859591 1.10507829381097 0.454545454545455 10.1 10 1 abnormal circulating lipid level 0.0772794545236145 0.290611309859591 1.10507829381097 0.454545454545455 10.1 10 1 abnormal limb posture 0.0772794545236145 0.290611309859591 1.10507829381097 0.454545454545455 10.1 10 1 abnormal basement membrane morphology 0.0772794545236145 0.290611309859591 1.10507829381097 0.454545454545455 10.1 10 1 cleft upper lip 0.0772794545236145 0.290611309859591 1.10507829381097 0.454545454545455 10.1 10 1 abnormal cerebral cortex pyramidal cell morphology 0.0772794545236145 0.290611309859591 1.10507829381097 0.454545454545455 10.1 10 1 increased adenoma incidence 0.0772794545236145 0.290611309859591 1.10507829381097 0.454545454545455 10.1 10 1 impaired humoral immune response 0.0772794545236145 0.290611309859591 1.10507829381097 0.454545454545455 10.1 10 1 abnormal ear position 0.191830907660326 0.49823504793006 1.10507829381097 0.454545454545455 10.1 10 1 abnormal enteric ganglia morphology 0.191830907660326 0.49823504793006 1.10507829381097 0.454545454545455 10.1 10 1 abnormal food preference 0.191830907660326 0.49823504793006 1.10507829381097 0.454545454545455 10.1 10 1 vasculitis 0.191830907660326 0.49823504793006 1.10507829381097 0.454545454545455 10.1 10 1 abnormal fear/anxiety-related behavior 0.191830907660326 0.49823504793006 1.10507829381097 0.454545454545455 10.1 10 1 abnormal bronchiole morphology 0.191830907660326 0.49823504793006 1.10507829381097 0.454545454545455 10.1 10 1 abnormal vestibular ganglion morphology 0.191830907660326 0.49823504793006 1.10507829381097 0.454545454545455 10.1 10 1 decreased post-tetanic potentiation 0.191830907660326 0.49823504793006 1.10507829381097 0.454545454545455 10.1 10 1 allodynia 0.191830907660326 0.49823504793006 1.10507829381097 0.454545454545455 10.1 10 1 rectal hemorrhage 0.191830907660326 0.49823504793006 1.10507829381097 0.454545454545455 10.1 10 1 abnormal nerve fiber response 0.191830907660326 0.49823504793006 1.10507829381097 0.454545454545455 10.1 10 1 pulmonary hypertension 0.191830907660326 0.49823504793006 1.10507829381097 0.454545454545455 10.1 10 1 dilated renal glomerular capsule 0.191830907660326 0.49823504793006 1.10507829381097 0.454545454545455 10.1 10 1 pathological neovascularization 0.191830907660326 0.49823504793006 1.10507829381097 0.454545454545455 10.1 10 1 cyclopia 0.191830907660326 0.49823504793006 1.10507829381097 0.454545454545455 10.1 10 1 abnormal Bruch membrane morphology 0.191830907660326 0.49823504793006 1.10507829381097 0.454545454545455 10.1 10 1 increased glycogen level 0.191830907660326 0.49823504793006 1.10507829381097 0.454545454545455 10.1 10 1 abnormal platelet aggregation 0.191830907660326 0.49823504793006 1.10507829381097 0.454545454545455 10.1 10 1 abnormal superovulation 0.191830907660326 0.49823504793006 1.10507829381097 0.454545454545455 10.1 10 1 enhanced behavioral response to addictive substance 0.191830907660326 0.49823504793006 1.10507829381097 0.454545454545455 10.1 10 1 abnormal aorta smooth muscle morphology 0.191830907660326 0.49823504793006 1.10507829381097 0.454545454545455 10.1 10 1 increased number of Howell-Jolly bodies 0.191830907660326 0.49823504793006 1.10507829381097 0.454545454545455 10.1 10 1 aberrant origin of the right subclavian artery 0.191830907660326 0.49823504793006 1.10507829381097 0.454545454545455 10.1 10 1 shortened PR interval 0.191830907660326 0.49823504793006 1.10507829381097 0.454545454545455 10.1 10 1 increased subcutaneous adipose tissue amount 0.191830907660326 0.49823504793006 1.10507829381097 0.454545454545455 10.1 10 1 reduced sympathetic cervical ganglion size 0.191830907660326 0.49823504793006 1.10507829381097 0.454545454545455 10.1 10 1 reduced male fertility 1.49993232735453e-07 9.32770416073596e-06 1.10313101928443 0.45374449339207 10.1 10 1 short snout 0.000250135298922364 0.0046450902106009 1.10303185252614 0.453703703703704 10.1 10 1 kyphosis 1.86030392563391e-05 0.000608882370396624 1.10213141836081 0.453333333333333 10.1 10 1 increased anxiety-related response 3.72538953116737e-05 0.00104710807443829 1.10189821238993 0.453237410071942 10.1 10 1 decreased caudal vertebrae number 0.00437223976930354 0.0418372875963529 1.10162492414281 0.453125 10.1 10 1 azoospermia 1.12767087957527e-05 0.000388265067225845 1.10090818704188 0.452830188679245 10.1 10 1 abnormal pancreatic islet morphology 0.00914309478418177 0.0694456435897776 1.10090818704188 0.452830188679245 10.1 10 1 increased circulating bilirubin level 0.00914309478418177 0.0694456435897776 1.10090818704188 0.452830188679245 10.1 10 1 alopecia 0.00061661766788544 0.00976965890996836 1.10042533257387 0.452631578947368 10.1 10 1 impaired righting response 0.00061661766788544 0.00976965890996836 1.10042533257387 0.452631578947368 10.1 10 1 postnatal growth retardation 1.22725807243668e-17 5.08800742531042e-15 1.10038351674576 0.452614379084967 10.1 10 1 skin edema 0.0194439648207218 0.121524780129511 1.0998160162214 0.452380952380952 10.1 10 1 seminiferous tubule degeneration 0.00258143994041491 0.0282256345133279 1.09902307028324 0.452054794520548 10.1 10 1 distended abdomen 0.0112201405910335 0.0796293857922848 1.0964110130752 0.450980392156863 10.1 10 1 abnormal posture 0.00186596435491916 0.0225867948071115 1.09402751087286 0.45 10.1 10 1 decreased circulating phosphate level 0.0239761884948892 0.141832981881182 1.09402751087286 0.45 10.1 10 1 impaired ovarian folliculogenesis 0.0239761884948892 0.141832981881182 1.09402751087286 0.45 10.1 10 1 abnormal pancreatic beta cell morphology 0.0239761884948892 0.141832981881182 1.09402751087286 0.45 10.1 10 1 abnormal dopamine level 0.0972742803770105 0.319221335669939 1.09402751087286 0.45 10.1 10 1 absent placental labyrinth 0.0972742803770105 0.319221335669939 1.09402751087286 0.45 10.1 10 1 abnormal postnatal subventricular zone morphology 0.0972742803770105 0.319221335669939 1.09402751087286 0.45 10.1 10 1 abnormal incus morphology 0.0972742803770105 0.319221335669939 1.09402751087286 0.45 10.1 10 1 decreased circulating VLDL cholesterol level 0.0972742803770105 0.319221335669939 1.09402751087286 0.45 10.1 10 1 abnormal circulating cytokine level 0.0972742803770105 0.319221335669939 1.09402751087286 0.45 10.1 10 1 epidermal hyperplasia 0.00654268436445572 0.0566084429794212 1.09402751087286 0.45 10.1 10 1 abnormal incisor morphology 0.00654268436445572 0.0566084429794212 1.09402751087286 0.45 10.1 10 1 abnormal coat appearance 0.00384485629876988 0.0376538584377562 1.09226579185374 0.449275362318841 10.1 10 1 improved glucose tolerance 1.99190533791326e-06 8.92768383434098e-05 1.09154672286635 0.448979591836735 10.1 10 1 abnormal enzyme/coenzyme level 0.00800475932558084 0.063616098474065 1.08983583458599 0.448275862068966 10.1 10 1 abnormal microglial cell morphology 0.0527734623039137 0.236956656102862 1.08983583458599 0.448275862068966 10.1 10 1 decreased granulocyte number 0.0527734623039137 0.236956656102862 1.08983583458599 0.448275862068966 10.1 10 1 aphagia 0.0527734623039137 0.236956656102862 1.08983583458599 0.448275862068966 10.1 10 1 absent long term depression 0.0527734623039137 0.236956656102862 1.08983583458599 0.448275862068966 10.1 10 1 abnormal outer ear morphology 0.0527734623039137 0.236956656102862 1.08983583458599 0.448275862068966 10.1 10 1 abnormal spatial learning 1.57564874163363e-05 0.000529652195245088 1.08880720236836 0.447852760736196 10.1 10 1 abnormal humoral immune response 0.000481502030272086 0.00803849865974372 1.08823900552433 0.447619047619048 10.1 10 1 persistence of hyaloid vascular system 0.0295822364158128 0.15639917765002 1.08762968917185 0.447368421052632 10.1 10 1 hepatic necrosis 0.0169104855814443 0.108563796290454 1.08626845051206 0.446808510638298 10.1 10 1 decreased litter size 3.14457687969183e-08 2.44441718382295e-06 1.08148231600718 0.444839857651246 10.1 10 1 abnormal CNS synaptic transmission 0.000859609521995418 0.0128741642256753 1.08052099839295 0.444444444444444 10.1 10 1 abnormal neuron morphology 0.000859609521995418 0.0128741642256753 1.08052099839295 0.444444444444444 10.1 10 1 cochlear outer hair cell degeneration 0.00410673311012437 0.0396718392677063 1.08052099839295 0.444444444444444 10.1 10 1 increased circulating corticosterone level 0.0207688826214396 0.128036172294501 1.08052099839295 0.444444444444444 10.1 10 1 cardiomyopathy 0.0207688826214396 0.128036172294501 1.08052099839295 0.444444444444444 10.1 10 1 lethality at weaning, complete penetrance 0.0207688826214396 0.128036172294501 1.08052099839295 0.444444444444444 10.1 10 1 heart right ventricle hypertrophy 0.0365218211975681 0.183549450277677 1.08052099839295 0.444444444444444 10.1 10 1 abnormal heart shape 0.122842423680487 0.375393770153821 1.08052099839295 0.444444444444444 10.1 10 1 right pulmonary isomerism 0.122842423680487 0.375393770153821 1.08052099839295 0.444444444444444 10.1 10 1 abnormal retinal rod cell morphology 0.122842423680487 0.375393770153821 1.08052099839295 0.444444444444444 10.1 10 1 thick dermal layer 0.122842423680487 0.375393770153821 1.08052099839295 0.444444444444444 10.1 10 1 abnormal thymus cortex morphology 0.122842423680487 0.375393770153821 1.08052099839295 0.444444444444444 10.1 10 1 abnormal bile duct morphology 0.122842423680487 0.375393770153821 1.08052099839295 0.444444444444444 10.1 10 1 abnormal white adipose tissue morphology 0.122842423680487 0.375393770153821 1.08052099839295 0.444444444444444 10.1 10 1 acidosis 0.122842423680487 0.375393770153821 1.08052099839295 0.444444444444444 10.1 10 1 decreased cellular sensitivity to gamma-irradiation 0.122842423680487 0.375393770153821 1.08052099839295 0.444444444444444 10.1 10 1 increased circulating renin level 0.122842423680487 0.375393770153821 1.08052099839295 0.444444444444444 10.1 10 1 abnormal body wall morphology 0.122842423680487 0.375393770153821 1.08052099839295 0.444444444444444 10.1 10 1 decreased activity of thyroid 0.122842423680487 0.375393770153821 1.08052099839295 0.444444444444444 10.1 10 1 abnormal eye anterior chamber morphology 0.122842423680487 0.375393770153821 1.08052099839295 0.444444444444444 10.1 10 1 increased susceptibility to autoimmune disorder 0.122842423680487 0.375393770153821 1.08052099839295 0.444444444444444 10.1 10 1 abnormal aerobic respiration 0.122842423680487 0.375393770153821 1.08052099839295 0.444444444444444 10.1 10 1 decreased susceptibility to hepatic steatosis 0.00698876940879331 0.0585338851999103 1.08052099839295 0.444444444444444 10.1 10 1 abnormal chondrocyte morphology 0.0119854541440278 0.084458405618326 1.08052099839295 0.444444444444444 10.1 10 1 abnormal heart valve morphology 0.0656834047928214 0.272539565341356 1.08052099839295 0.444444444444444 10.1 10 1 female infertility 9.02865374486234e-08 5.91020426061713e-06 1.07848994388469 0.443609022556391 10.1 10 1 decreased grip strength 1.30401079445504e-06 6.17852733563221e-05 1.07682058401489 0.442922374429224 10.1 10 1 thick epidermis 0.00500095494271026 0.0457348361029109 1.07666199482726 0.442857142857143 10.1 10 1 cleft palate 0.000163086597269677 0.00340905807317918 1.07639687244489 0.442748091603053 10.1 10 1 increased osteoclast cell number 0.00852878554182324 0.0669254070513732 1.07609263364544 0.442622950819672 10.1 10 1 decreased cardiac muscle contractility 0.000754535848722476 0.0115858513808467 1.07532618590068 0.442307692307692 10.1 10 1 abnormal female meiosis 0.0146676755281876 0.0988776229711831 1.07532618590068 0.442307692307692 10.1 10 1 decreased body temperature 0.0146676755281876 0.0988776229711831 1.07532618590068 0.442307692307692 10.1 10 1 abnormal organ of Corti morphology 0.0255147008070742 0.14278474298672 1.07423889956509 0.441860465116279 10.1 10 1 delayed endochondral bone ossification 0.0255147008070742 0.14278474298672 1.07423889956509 0.441860465116279 10.1 10 1 abnormal double-strand DNA break repair 0.0255147008070742 0.14278474298672 1.07423889956509 0.441860465116279 10.1 10 1 kinked tail 0.00091380136117891 0.0134501827569973 1.07257599105183 0.441176470588235 10.1 10 1 abnormal brown adipose tissue morphology 0.0451190315295562 0.213982060876589 1.07257599105183 0.441176470588235 10.1 10 1 increased width of hypertrophic chondrocyte zone 0.0451190315295562 0.213982060876589 1.07257599105183 0.441176470588235 10.1 10 1 abnormal direction of heart looping 0.0451190315295562 0.213982060876589 1.07257599105183 0.441176470588235 10.1 10 1 abnormal skin physiology 0.0451190315295562 0.213982060876589 1.07257599105183 0.441176470588235 10.1 10 1 abnormal colon morphology 0.0104076561881258 0.0748238288091415 1.07136404077945 0.440677966101695 10.1 10 1 decreased inflammatory response 0.00257857160060281 0.0282256345133279 1.07087348947873 0.44047619047619 10.1 10 1 delayed bone ossification 0.00435958425383283 0.0418372875963529 1.06971578840902 0.44 10.1 10 1 abnormal limb morphology 0.00435958425383283 0.0418372875963529 1.06971578840902 0.44 10.1 10 1 decreased circulating alkaline phosphatase level 0.0179513495131694 0.114204557324831 1.06971578840902 0.44 10.1 10 1 mandible hypoplasia 0.0818741546769245 0.290611309859591 1.06971578840902 0.44 10.1 10 1 abnormal feces composition 0.0818741546769245 0.290611309859591 1.06971578840902 0.44 10.1 10 1 impaired swimming 0.00741326103943521 0.0600667323635019 1.06824235068394 0.439393939393939 10.1 10 1 abnormal skin morphology 0.00741326103943521 0.0600667323635019 1.06824235068394 0.439393939393939 10.1 10 1 impaired coordination 3.15523110138954e-09 3.2702655686277e-07 1.06802942615719 0.439306358381503 10.1 10 1 abnormal developmental patterning 0.00312869605568566 0.0329772518581274 1.0673439130467 0.439024390243902 10.1 10 1 thick ventricular wall 0.0313536199711695 0.163988563317037 1.0673439130467 0.439024390243902 10.1 10 1 short ulna 0.0313536199711695 0.163988563317037 1.0673439130467 0.439024390243902 10.1 10 1 hemopericardium 0.0313536199711695 0.163988563317037 1.0673439130467 0.439024390243902 10.1 10 1 polydactyly 0.00133935101229029 0.0174391300307673 1.0667388428012 0.438775510204082 10.1 10 1 cardiac hypertrophy 0.00133935101229029 0.0174391300307673 1.0667388428012 0.438775510204082 10.1 10 1 decreased brain weight 0.0126995905304307 0.0886121499142956 1.06630361683515 0.43859649122807 10.1 10 1 neonatal lethality, incomplete penetrance 3.08454983919472e-07 1.76386614367744e-05 1.06597552341458 0.438461538461538 10.1 10 1 small testis 1.37557016918523e-07 8.77366870730323e-06 1.06584000656696 0.438405797101449 10.1 10 1 postnatal lethality, incomplete penetrance 4.75846306574365e-14 1.39255022071027e-11 1.06577797420713 0.438380281690141 10.1 10 1 anophthalmia 0.00224994077344424 0.025732081259506 1.06534514167395 0.438202247191011 10.1 10 1 abnormal urine homeostasis 0.00162088154225683 0.0203633476584034 1.06363785779306 0.4375 10.1 10 1 abnormal tooth morphology 0.00902384801728529 0.0687498374976942 1.06363785779306 0.4375 10.1 10 1 decreased eosinophil cell number 0.00902384801728529 0.0687498374976942 1.06363785779306 0.4375 10.1 10 1 abnormal intestinal epithelium morphology 0.0219712523635469 0.131220864956358 1.06363785779306 0.4375 10.1 10 1 abnormal kidney physiology 0.0219712523635469 0.131220864956358 1.06363785779306 0.4375 10.1 10 1 abnormal vertebral body morphology 0.0557786879772297 0.24644668977506 1.06363785779306 0.4375 10.1 10 1 pancreatic islet hyperplasia 0.0557786879772297 0.24644668977506 1.06363785779306 0.4375 10.1 10 1 abnormal bone marrow cell number 0.155731528133873 0.438215131485303 1.06363785779306 0.4375 10.1 10 1 mixed cellular infiltration to dermis 0.155731528133873 0.438215131485303 1.06363785779306 0.4375 10.1 10 1 reduced male mating frequency 0.155731528133873 0.438215131485303 1.06363785779306 0.4375 10.1 10 1 abnormal extraembryonic endoderm formation 0.155731528133873 0.438215131485303 1.06363785779306 0.4375 10.1 10 1 white spotting 0.155731528133873 0.438215131485303 1.06363785779306 0.4375 10.1 10 1 large intestinal inflammation 0.155731528133873 0.438215131485303 1.06363785779306 0.4375 10.1 10 1 increased pancreatic beta cell number 0.155731528133873 0.438215131485303 1.06363785779306 0.4375 10.1 10 1 bowed tibia 0.155731528133873 0.438215131485303 1.06363785779306 0.4375 10.1 10 1 abnormal wound healing 0.155731528133873 0.438215131485303 1.06363785779306 0.4375 10.1 10 1 decreased circulating growth hormone level 0.155731528133873 0.438215131485303 1.06363785779306 0.4375 10.1 10 1 decreased skeletal muscle weight 0.155731528133873 0.438215131485303 1.06363785779306 0.4375 10.1 10 1 embryonic lethality between somite formation and embryo turning, incomplete penetrance 0.155731528133873 0.438215131485303 1.06363785779306 0.4375 10.1 10 1 decreased fibroblast apoptosis 0.155731528133873 0.438215131485303 1.06363785779306 0.4375 10.1 10 1 decreased circulating cholesterol level 1.88256397809721e-05 0.000612140901374746 1.0628075394029 0.437158469945355 10.1 10 1 abnormal skeletal muscle fiber morphology 0.00643511624418835 0.0558720825738867 1.06149774137899 0.436619718309859 10.1 10 1 abnormal learning/memory/conditioning 0.015494861214895 0.103333692418368 1.06087516205853 0.436363636363636 10.1 10 1 increased rib number 0.0046028063328239 0.0430431607251859 1.05974174842386 0.435897435897436 10.1 10 1 abnormal cornea morphology 0.0046028063328239 0.0430431607251859 1.05974174842386 0.435897435897436 10.1 10 1 increased circulating alanine transaminase level 0.0046028063328239 0.0430431607251859 1.05974174842386 0.435897435897436 10.1 10 1 increased urine protein level 0.0046028063328239 0.0430431607251859 1.05974174842386 0.435897435897436 10.1 10 1 abnormal lung development 0.00330057188601793 0.0337867183805333 1.0582749778378 0.435294117647059 10.1 10 1 abnormal axon morphology 0.00102028518061752 0.0147555778301517 1.05801014425976 0.435185185185185 10.1 10 1 hyperkeratosis 0.00781561003627632 0.062325639040374 1.05703141147137 0.434782608695652 10.1 10 1 abnormal forelimb morphology 0.0268921288830726 0.147020155157457 1.05703141147137 0.434782608695652 10.1 10 1 abnormal cranial nerve morphology 0.102225548259915 0.334147242176791 1.05703141147137 0.434782608695652 10.1 10 1 abnormal nasal cavity morphology 0.102225548259915 0.334147242176791 1.05703141147137 0.434782608695652 10.1 10 1 abnormal B cell morphology 0.102225548259915 0.334147242176791 1.05703141147137 0.434782608695652 10.1 10 1 abnormal basicranium morphology 0.102225548259915 0.334147242176791 1.05703141147137 0.434782608695652 10.1 10 1 decreased effector memory CD8-positive, alpha-beta T cell number 0.102225548259915 0.334147242176791 1.05703141147137 0.434782608695652 10.1 10 1 abnormal vertebral artery topology 0.102225548259915 0.334147242176791 1.05703141147137 0.434782608695652 10.1 10 1 abnormal blood vessel morphology 0.000169042578540054 0.00347515218279656 1.05630242429104 0.43448275862069 10.1 10 1 abnormal motor coordination/ balance 0.00170772394233815 0.0214003189247665 1.05596370297493 0.434343434343434 10.1 10 1 abnormal glucose homeostasis 2.8669048637041e-05 0.000854062975863945 1.05528905200191 0.434065934065934 10.1 10 1 enlarged kidney 0.0189031874319255 0.118293531413622 1.0550370125818 0.433962264150943 10.1 10 1 increased bone mineral density 0.000889404230373221 0.0131299289201981 1.05422513338781 0.433628318584071 10.1 10 1 male infertility 6.69939715826506e-12 1.14929313318513e-09 1.053669084914 0.433399602385686 10.1 10 1 abnormal heart tube morphology 0.0690068877639002 0.282094713743142 1.05350797343313 0.433333333333333 10.1 10 1 arrested T cell differentiation 0.0690068877639002 0.282094713743142 1.05350797343313 0.433333333333333 10.1 10 1 salivary gland inflammation 0.0690068877639002 0.282094713743142 1.05350797343313 0.433333333333333 10.1 10 1 abnormal lactation 0.0690068877639002 0.282094713743142 1.05350797343313 0.433333333333333 10.1 10 1 abnormal estrous cycle 0.0690068877639002 0.282094713743142 1.05350797343313 0.433333333333333 10.1 10 1 emphysema 0.0690068877639002 0.282094713743142 1.05350797343313 0.433333333333333 10.1 10 1 cachexia 0.00148603277479793 0.0189564437297942 1.05194952968545 0.432692307692308 10.1 10 1 malocclusion 0.0473837939227105 0.222600920458437 1.05131772816612 0.432432432432432 10.1 10 1 abnormal vocalization 0.0473837939227105 0.222600920458437 1.05131772816612 0.432432432432432 10.1 10 1 abnormal chromosome morphology 0.0473837939227105 0.222600920458437 1.05131772816612 0.432432432432432 10.1 10 1 abnormal hair follicle development 0.0473837939227105 0.222600920458437 1.05131772816612 0.432432432432432 10.1 10 1 abnormal calcium ion homeostasis 0.0473837939227105 0.222600920458437 1.05131772816612 0.432432432432432 10.1 10 1 abnormal respiratory electron transport chain 0.0473837939227105 0.222600920458437 1.05131772816612 0.432432432432432 10.1 10 1 cyanosis 2.19457762253049e-05 0.00069101415646134 1.05097550234314 0.432291666666667 10.1 10 1 abnormal skeleton development 0.00483596652242894 0.0445535804612667 1.05050652621537 0.432098765432099 10.1 10 1 abnormal astrocyte morphology 0.0329151825866346 0.169131267905512 1.04982437912042 0.431818181818182 10.1 10 1 cochlear hair cell degeneration 0.0329151825866346 0.169131267905512 1.04982437912042 0.431818181818182 10.1 10 1 lethality, incomplete penetrance 0.0329151825866346 0.169131267905512 1.04982437912042 0.431818181818182 10.1 10 1 abnormal eye morphology 0.000294268089036437 0.00538229317263335 1.04942686894279 0.431654676258993 10.1 10 1 decreased birth weight 0.00249033866911519 0.027530433830058 1.04924275896579 0.431578947368421 10.1 10 1 abnormal trophoblast layer morphology 0.0230577838678933 0.137051941150262 1.04874096902845 0.431372549019608 10.1 10 1 hydrops fetalis 0.00819560105287097 0.0649253427357214 1.04675471719317 0.430555555555556 10.1 10 1 abnormal placenta labyrinth morphology 0.00585066901203811 0.0513352351585354 1.04632729591216 0.430379746835443 10.1 10 1 abnormal rib morphology 0.000425115161599875 0.0072182523172675 1.04450363177985 0.42962962962963 10.1 10 1 increased sensitivity to induced morbidity/mortality 4.53898345842566e-05 0.00123395861779605 1.04381851882797 0.429347826086957 10.1 10 1 increased thermal nociceptive threshold 0.00362618669012622 0.0361528632933426 1.04193096273606 0.428571428571429 10.1 10 1 abnormal locomotor activation 0.00362618669012622 0.0361528632933426 1.04193096273606 0.428571428571429 10.1 10 1 abnormal seminal vesicle morphology 0.0197701345454831 0.123408305349784 1.04193096273606 0.428571428571429 10.1 10 1 myoclonus 0.0854367298776409 0.291128582973468 1.04193096273606 0.428571428571429 10.1 10 1 small superior cervical ganglion 0.0854367298776409 0.291128582973468 1.04193096273606 0.428571428571429 10.1 10 1 abnormal respiration 0.0854367298776409 0.291128582973468 1.04193096273606 0.428571428571429 10.1 10 1 straub tail 0.0854367298776409 0.291128582973468 1.04193096273606 0.428571428571429 10.1 10 1 failure of blastocyst to hatch from the zona pellucida 0.0854367298776409 0.291128582973468 1.04193096273606 0.428571428571429 10.1 10 1 abnormal renal tubule epithelium morphology 0.0854367298776409 0.291128582973468 1.04193096273606 0.428571428571429 10.1 10 1 translucent skin 0.19834452366342 0.49823504793006 1.04193096273606 0.428571428571429 10.1 10 1 decreased vascular permeability 0.19834452366342 0.49823504793006 1.04193096273606 0.428571428571429 10.1 10 1 abnormal ventral body wall morphology 0.19834452366342 0.49823504793006 1.04193096273606 0.428571428571429 10.1 10 1 abnormal hair cuticle 0.19834452366342 0.49823504793006 1.04193096273606 0.428571428571429 10.1 10 1 decreased CNS synapse formation 0.19834452366342 0.49823504793006 1.04193096273606 0.428571428571429 10.1 10 1 abnormal glucose tolerance 0.19834452366342 0.49823504793006 1.04193096273606 0.428571428571429 10.1 10 1 decreased compact bone area 0.19834452366342 0.49823504793006 1.04193096273606 0.428571428571429 10.1 10 1 multiple persisting craniopharyngeal ducts 0.19834452366342 0.49823504793006 1.04193096273606 0.428571428571429 10.1 10 1 decreased bone mineral density 1.23365320489014e-06 5.95866475177521e-05 1.04193096273606 0.428571428571429 10.1 10 1 abnormal nervous system electrophysiology 0.00505877560612983 0.0460941550192232 1.04193096273606 0.428571428571429 10.1 10 1 increased food intake 0.00505877560612983 0.0460941550192232 1.04193096273606 0.428571428571429 10.1 10 1 abnormal vibrissa morphology 0.0402858613340054 0.199425034961868 1.04193096273606 0.428571428571429 10.1 10 1 abnormal muscle morphology 0.0402858613340054 0.199425034961868 1.04193096273606 0.428571428571429 10.1 10 1 abnormal salivary gland morphology 0.12787118319534 0.389803392400011 1.04193096273606 0.428571428571429 10.1 10 1 abnormal anxiety-related response 0.12787118319534 0.389803392400011 1.04193096273606 0.428571428571429 10.1 10 1 hypoalgesia 0.12787118319534 0.389803392400011 1.04193096273606 0.428571428571429 10.1 10 1 dry skin 0.12787118319534 0.389803392400011 1.04193096273606 0.428571428571429 10.1 10 1 increased startle reflex 0.00437294262313639 0.0418372875963529 1.03802859957975 0.426966292134831 10.1 10 1 abnormal neurocranium morphology 0.00855328075957437 0.0670119240612323 1.03730015845723 0.426666666666667 10.1 10 1 abnormal long bone epiphyseal plate proliferative zone 0.0240356992261721 0.142016156354164 1.03549929012658 0.425925925925926 10.1 10 1 abnormal retinal pigment epithelium morphology 0.00736984465970087 0.0599100934346598 1.03324820471326 0.425 10.1 10 1 abnormal female reproductive system morphology 0.0493031275163969 0.230529191159844 1.03324820471326 0.425 10.1 10 1 head bobbing 0.0493031275163969 0.230529191159844 1.03324820471326 0.425 10.1 10 1 postnatal lethality, complete penetrance 1.38411260883948e-08 1.2519927689048e-06 1.03293328602849 0.424870466321244 10.1 10 1 increased mean corpuscular hemoglobin 0.0032661981385412 0.0335677275831593 1.03140640755691 0.424242424242424 10.1 10 1 dilated heart atrium 0.0716774992225258 0.289209698809461 1.03140640755691 0.424242424242424 10.1 10 1 abnormal QRS complex 0.0716774992225258 0.289209698809461 1.03140640755691 0.424242424242424 10.1 10 1 increased osteoblast cell number 0.0716774992225258 0.289209698809461 1.03140640755691 0.424242424242424 10.1 10 1 abnormal middle ear ossicle morphology 0.0716774992225258 0.289209698809461 1.03140640755691 0.424242424242424 10.1 10 1 abnormal excitatory postsynaptic currents 0.0088888993144235 0.0680389878130877 1.02857287347021 0.423076923076923 10.1 10 1 increased susceptibility to otitis media 0.105860322147284 0.341318925912338 1.02857287347021 0.423076923076923 10.1 10 1 abnormal ocular fundus morphology 0.105860322147284 0.341318925912338 1.02857287347021 0.423076923076923 10.1 10 1 weight loss 0.000138862672985178 0.00305060341147461 1.02803854989958 0.422857142857143 10.1 10 1 decreased anxiety-related response 0.00126956792643041 0.0173095447453598 1.02781265700793 0.422764227642276 10.1 10 1 increased circulating free fatty acid level 0.0124813465605453 0.0873343166507914 1.02725587875386 0.422535211267606 10.1 10 1 decreased liver weight 0.0124813465605453 0.0873343166507914 1.02725587875386 0.422535211267606 10.1 10 1 altered response to myocardial infarction 0.0417913248688927 0.203237381449405 1.0264949484733 0.422222222222222 10.1 10 1 abnormal ovarian follicle morphology 0.0417913248688927 0.203237381449405 1.0264949484733 0.422222222222222 10.1 10 1 small placenta 0.0417913248688927 0.203237381449405 1.0264949484733 0.422222222222222 10.1 10 1 decreased total body fat amount 2.16800454598439e-07 1.28402650193718e-05 1.02633319383283 0.422155688622754 10.1 10 1 abnormal renal glomerulus morphology 0.0024390574795309 0.0272069752481306 1.02599929663918 0.422018348623853 10.1 10 1 respiratory distress 0.000165869951827526 0.00343834587642475 1.02587036986152 0.421965317919075 10.1 10 1 increased sacral vertebrae number 0.0175924873124851 0.112064819948288 1.02565079144331 0.421875 10.1 10 1 hypoactivity 4.10567094050348e-08 3.04861387000072e-06 1.0253485070957 0.421750663129974 10.1 10 1 abnormal lipid level 0.00764697875075251 0.0617592845535613 1.02519311594512 0.421686746987952 10.1 10 1 small superior vagus ganglion 0.16027806981841 0.448472101994707 1.02365147216174 0.421052631578947 10.1 10 1 thin dermal layer 0.16027806981841 0.448472101994707 1.02365147216174 0.421052631578947 10.1 10 1 decreased grooming behavior 0.16027806981841 0.448472101994707 1.02365147216174 0.421052631578947 10.1 10 1 abnormal digestive system development 0.16027806981841 0.448472101994707 1.02365147216174 0.421052631578947 10.1 10 1 increased liver adenoma incidence 0.16027806981841 0.448472101994707 1.02365147216174 0.421052631578947 10.1 10 1 abnormal blastocyst morphology 0.16027806981841 0.448472101994707 1.02365147216174 0.421052631578947 10.1 10 1 decreased fertilization frequency 0.16027806981841 0.448472101994707 1.02365147216174 0.421052631578947 10.1 10 1 shortened RR interval 0.16027806981841 0.448472101994707 1.02365147216174 0.421052631578947 10.1 10 1 thin interventricular septum 0.16027806981841 0.448472101994707 1.02365147216174 0.421052631578947 10.1 10 1 abnormal gait 7.84775563925773e-07 4.0018819554443e-05 1.02282327517779 0.420711974110032 10.1 10 1 increased circulating triglyceride level 0.000596930797492979 0.00957977650815344 1.02276901399609 0.420689655172414 10.1 10 1 abnormal trabecular bone morphology 0.00182151288475863 0.022156544258372 1.02150094385888 0.420168067226891 10.1 10 1 decreased heart rate 0.00406627606062893 0.0393574385245698 1.02109234348134 0.42 10.1 10 1 reduced long term potentiation 0.00252510366454505 0.0277315468677961 1.02022406767906 0.419642857142857 10.1 10 1 lethargy 0.00566388839054931 0.0502956104192238 1.01952384525787 0.419354838709677 10.1 10 1 increased lung adenoma incidence 0.0881807277527319 0.295565976108634 1.01952384525787 0.419354838709677 10.1 10 1 abnormal retinal photoreceptor layer morphology 0.0881807277527319 0.295565976108634 1.01952384525787 0.419354838709677 10.1 10 1 preaxial polydactyly 0.0881807277527319 0.295565976108634 1.01952384525787 0.419354838709677 10.1 10 1 spleen hypoplasia 0.00350594745935413 0.035596099204667 1.01877694134193 0.419047619047619 10.1 10 1 abnormal liver morphology 0.000177765063168461 0.00362139229013276 1.0186475892671 0.418994413407821 10.1 10 1 abnormal male reproductive system morphology 0.0509210969133955 0.232710507300576 1.01770001011429 0.418604651162791 10.1 10 1 decreased circulating calcium level 0.0301744265467776 0.159191698907973 1.0166720303061 0.418181818181818 10.1 10 1 abnormal joint morphology 0.0301744265467776 0.159191698907973 1.0166720303061 0.418181818181818 10.1 10 1 limb grasping 0.000183602132838551 0.00371309191411298 1.01521478420437 0.417582417582418 10.1 10 1 abnormal craniofacial morphology 0.0041997180766633 0.04049146789031 1.01495540383027 0.41747572815534 10.1 10 1 insulin resistance 0.00140407797962645 0.0181908540329209 1.01298843599339 0.416666666666667 10.1 10 1 hydronephrosis 0.00949569528262587 0.0706554586523516 1.01298843599339 0.416666666666667 10.1 10 1 oligodactyly 0.0430821432879762 0.206288414684968 1.01298843599339 0.416666666666667 10.1 10 1 abnormal pharyngeal arch morphology 0.0738081392394673 0.290611309859591 1.01298843599339 0.416666666666667 10.1 10 1 abnormal adrenal gland morphology 0.131268125988722 0.398206662679203 1.01298843599339 0.416666666666667 10.1 10 1 abnormal body weight 0.131268125988722 0.398206662679203 1.01298843599339 0.416666666666667 10.1 10 1 curly vibrissae 0.131268125988722 0.398206662679203 1.01298843599339 0.416666666666667 10.1 10 1 abnormal nursing 0.131268125988722 0.398206662679203 1.01298843599339 0.416666666666667 10.1 10 1 abnormal sensory capabilities/reflexes/nociception 0.131268125988722 0.398206662679203 1.01298843599339 0.416666666666667 10.1 10 1 abnormal truncus arteriosus septation 0.131268125988722 0.398206662679203 1.01298843599339 0.416666666666667 10.1 10 1 abnormal mineral level 0.254052345847341 0.558314124616683 1.01298843599339 0.416666666666667 10.1 10 1 abnormal pilomotor reflex 0.254052345847341 0.558314124616683 1.01298843599339 0.416666666666667 10.1 10 1 increased litter size 0.254052345847341 0.558314124616683 1.01298843599339 0.416666666666667 10.1 10 1 increased growth rate 0.254052345847341 0.558314124616683 1.01298843599339 0.416666666666667 10.1 10 1 abnormal corticospinal tract morphology 0.254052345847341 0.558314124616683 1.01298843599339 0.416666666666667 10.1 10 1 abnormal AMPA-mediated synaptic currents 0.254052345847341 0.558314124616683 1.01298843599339 0.416666666666667 10.1 10 1 decreased synaptic depression 0.254052345847341 0.558314124616683 1.01298843599339 0.416666666666667 10.1 10 1 small thyroid gland 0.254052345847341 0.558314124616683 1.01298843599339 0.416666666666667 10.1 10 1 abnormal alisphenoid bone morphology 0.254052345847341 0.558314124616683 1.01298843599339 0.416666666666667 10.1 10 1 loss of dopaminergic neurons 0.254052345847341 0.558314124616683 1.01298843599339 0.416666666666667 10.1 10 1 decreased left ventricle systolic pressure 0.254052345847341 0.558314124616683 1.01298843599339 0.416666666666667 10.1 10 1 increased hepatocyte proliferation 0.254052345847341 0.558314124616683 1.01298843599339 0.416666666666667 10.1 10 1 stria vascularis degeneration 0.254052345847341 0.558314124616683 1.01298843599339 0.416666666666667 10.1 10 1 absent cochlear hair cells 0.254052345847341 0.558314124616683 1.01298843599339 0.416666666666667 10.1 10 1 decreased cochlear nerve compound action potential 0.254052345847341 0.558314124616683 1.01298843599339 0.416666666666667 10.1 10 1 decreased prostaglandin level 0.254052345847341 0.558314124616683 1.01298843599339 0.416666666666667 10.1 10 1 increased or absent threshold for auditory brainstem response 4.39308330988979e-06 0.000176040463578132 1.00948328569584 0.41522491349481 10.1 10 1 atrioventricular septal defect 0.0365254182462112 0.183549450277677 1.00916583812172 0.415094339622642 10.1 10 1 abnormal cholesterol homeostasis 0.0620173620275996 0.266120168205467 1.00804702898855 0.414634146341463 10.1 10 1 glomerulosclerosis 0.031022513695184 0.163492590713496 1.00600230884861 0.413793103448276 10.1 10 1 focal hair loss 0.108493154047331 0.349129004777148 1.00600230884861 0.413793103448276 10.1 10 1 increased double-positive T cell number 0.108493154047331 0.349129004777148 1.00600230884861 0.413793103448276 10.1 10 1 abnormal sleep pattern 0.0522759442663215 0.235786783975476 1.0041798408978 0.41304347826087 10.1 10 1 increased circulating aspartate transaminase level 0.0263905273554722 0.146067271983839 1.00334092707917 0.412698412698413 10.1 10 1 abnormal response to novel object 0.0441820458970801 0.211351613786513 1.0010709249817 0.411764705882353 10.1 10 1 lung hemorrhage 0.0902684266076045 0.300153190420097 1.0010709249817 0.411764705882353 10.1 10 1 impaired synaptic plasticity 0.0902684266076045 0.300153190420097 1.0010709249817 0.411764705882353 10.1 10 1 increased susceptibility to weight gain 0.0902684266076045 0.300153190420097 1.0010709249817 0.411764705882353 10.1 10 1 abnormal heart rate 0.201352450656851 0.49823504793006 1.0010709249817 0.411764705882353 10.1 10 1 abnormal glutamate-mediated receptor currents 0.201352450656851 0.49823504793006 1.0010709249817 0.411764705882353 10.1 10 1 abnormal involuntary movement 0.201352450656851 0.49823504793006 1.0010709249817 0.411764705882353 10.1 10 1 abnormal tarsal bone morphology 0.201352450656851 0.49823504793006 1.0010709249817 0.411764705882353 10.1 10 1 increased circulating magnesium level 0.201352450656851 0.49823504793006 1.0010709249817 0.411764705882353 10.1 10 1 common atrium 0.201352450656851 0.49823504793006 1.0010709249817 0.411764705882353 10.1 10 1 abnormal electroretinogram waveform feature 0.201352450656851 0.49823504793006 1.0010709249817 0.411764705882353 10.1 10 1 decreased body fat mass 0.201352450656851 0.49823504793006 1.0010709249817 0.411764705882353 10.1 10 1 abnormal seminiferous tubule morphology 0.00131603847529501 0.0174391300307673 0.999111882075674 0.410958904109589 10.1 10 1 absent gastric milk in neonates 0.0163745148988317 0.107113440110536 0.997403998516571 0.41025641025641 10.1 10 1 increased embryonic tissue cell apoptosis 0.0163745148988317 0.107113440110536 0.997403998516571 0.41025641025641 10.1 10 1 acanthosis 0.0754894787783314 0.290611309859591 0.997403998516571 0.41025641025641 10.1 10 1 increased vascular permeability 0.0754894787783314 0.290611309859591 0.997403998516571 0.41025641025641 10.1 10 1 abnormal circulating hormone level 0.0754894787783314 0.290611309859591 0.997403998516571 0.41025641025641 10.1 10 1 no abnormal phenotype detected 2.13298898535766e-27 1.76860336702573e-24 0.996290182812175 0.409798270893372 10.1 10 1 short tail 0.0139965591988522 0.0947386149854281 0.995901884060973 0.409638554216867 10.1 10 1 abnormal motor capabilities/coordination/movement 0.0025004697841547 0.027530433830058 0.994570464429876 0.409090909090909 10.1 10 1 hyperglycemia 0.0119749060811619 0.084458405618326 0.994570464429876 0.409090909090909 10.1 10 1 renal interstitial fibrosis 0.0633867299088454 0.266120168205467 0.994570464429876 0.409090909090909 10.1 10 1 abnormal basisphenoid bone morphology 0.162896226121919 0.452237011694502 0.994570464429876 0.409090909090909 10.1 10 1 abnormal enterocyte morphology 0.162896226121919 0.452237011694502 0.994570464429876 0.409090909090909 10.1 10 1 abnormal tail movements 0.162896226121919 0.452237011694502 0.994570464429876 0.409090909090909 10.1 10 1 increased activated T cell number 0.162896226121919 0.452237011694502 0.994570464429876 0.409090909090909 10.1 10 1 testis hypoplasia 0.162896226121919 0.452237011694502 0.994570464429876 0.409090909090909 10.1 10 1 increased myocardial infarction size 0.162896226121919 0.452237011694502 0.994570464429876 0.409090909090909 10.1 10 1 decreased cardiac output 0.162896226121919 0.452237011694502 0.994570464429876 0.409090909090909 10.1 10 1 abnormal female reproductive system physiology 0.162896226121919 0.452237011694502 0.994570464429876 0.409090909090909 10.1 10 1 abnormal occipital bone morphology 0.162896226121919 0.452237011694502 0.994570464429876 0.409090909090909 10.1 10 1 rough coat 0.162896226121919 0.452237011694502 0.994570464429876 0.409090909090909 10.1 10 1 abnormal epidermis stratum corneum morphology 0.0534007368646435 0.239443316835552 0.992315202605772 0.408163265306122 10.1 10 1 axon degeneration 0.045112100072488 0.213982060876589 0.990477581860206 0.407407407407407 10.1 10 1 abnormal trigeminal nerve morphology 0.133481952828477 0.402359554617639 0.990477581860206 0.407407407407407 10.1 10 1 abnormal trigeminal ganglion morphology 0.133481952828477 0.402359554617639 0.990477581860206 0.407407407407407 10.1 10 1 thin epidermis 0.133481952828477 0.402359554617639 0.990477581860206 0.407407407407407 10.1 10 1 abnormal diaphragm morphology 0.110350544441233 0.354647260074377 0.987663725093557 0.40625 10.1 10 1 bradykinesia 0.110350544441233 0.354647260074377 0.987663725093557 0.40625 10.1 10 1 perimembraneous ventricular septal defect 0.0275465841117714 0.147142875886656 0.986562650706608 0.405797101449275 10.1 10 1 increased brown adipose tissue amount 0.0918247383190742 0.304146520064843 0.985610370155733 0.405405405405405 10.1 10 1 abnormal cartilage morphology 0.0767947824992438 0.290611309859591 0.984045909250724 0.404761904761905 10.1 10 1 decreased bone trabecula number 0.064483448018951 0.268456195727432 0.982814312368057 0.404255319148936 10.1 10 1 deafness 0.0106660352270107 0.0765707435128112 0.982291816720865 0.404040404040404 10.1 10 1 decreased IgA level 0.0543240405480947 0.240660820771835 0.981819561039749 0.403846153846154 10.1 10 1 decreased kidney weight 0.0543240405480947 0.240660820771835 0.981819561039749 0.403846153846154 10.1 10 1 increased hepatocellular carcinoma incidence 0.0458909543064662 0.21722882747352 0.980999327488338 0.403508771929825 10.1 10 1 abnormal facial morphology 0.0458909543064662 0.21722882747352 0.980999327488338 0.403508771929825 10.1 10 1 increased eosinophil cell number 0.0388572849294941 0.195070628177834 0.980311389671024 0.403225806451613 10.1 10 1 abnormal cranium morphology 0.00365815087649458 0.0363259493224761 0.979726129139878 0.402985074626866 10.1 10 1 abnormal femur morphology 0.0329675154203992 0.169131267905512 0.979726129139878 0.402985074626866 10.1 10 1 polyuria 0.0238498480442503 0.14159068498824 0.978783631661148 0.402597402597403 10.1 10 1 abnormal response/metabolism to endogenous compounds 0.0203283613620329 0.125944704577975 0.978398586959471 0.402439024390244 10.1 10 1 abnormal myocardial fiber morphology 0.0126729211934286 0.0885502569344201 0.977481624834861 0.402061855670103 10.1 10 1 enlarged liver 0.012864163976998 0.0890114266836787 0.972468898553656 0.4 10.1 10 1 abnormal circulating protein level 0.065345347870639 0.271363193369306 0.972468898553656 0.4 10.1 10 1 decreased oocyte number 0.065345347870639 0.271363193369306 0.972468898553656 0.4 10.1 10 1 decreased respiratory quotient 0.065345347870639 0.271363193369306 0.972468898553656 0.4 10.1 10 1 diaphragmatic hernia 0.164197440196587 0.453844756307973 0.972468898553656 0.4 10.1 10 1 increased cellular sensitivity to ionizing radiation 0.164197440196587 0.453844756307973 0.972468898553656 0.4 10.1 10 1 increased liver glycogen level 0.164197440196587 0.453844756307973 0.972468898553656 0.4 10.1 10 1 abnormal cell proliferation 0.202280596112676 0.49823504793006 0.972468898553656 0.4 10.1 10 1 abnormal lens epithelium morphology 0.202280596112676 0.49823504793006 0.972468898553656 0.4 10.1 10 1 enhanced behavioral response to xenobiotic 0.202280596112676 0.49823504793006 0.972468898553656 0.4 10.1 10 1 abnormal sperm mitochondrial sheath morphology 0.202280596112676 0.49823504793006 0.972468898553656 0.4 10.1 10 1 abnormal heart electrocardiography waveform feature 0.202280596112676 0.49823504793006 0.972468898553656 0.4 10.1 10 1 abnormal metabolism 0.0777836666021475 0.290611309859591 0.972468898553656 0.4 10.1 10 1 abnormal testis morphology 0.00808519618535627 0.0641528724436164 0.972468898553656 0.4 10.1 10 1 abnormal long bone epiphyseal plate morphology 0.0465350957221849 0.220068537279344 0.972468898553656 0.4 10.1 10 1 abnormal rostral-caudal axis patterning 0.0550705490896286 0.243750873417173 0.972468898553656 0.4 10.1 10 1 abnormal embryonic epiblast morphology 0.11159926208689 0.356662865835777 0.972468898553656 0.4 10.1 10 1 abnormal hippocampus pyramidal cell morphology 0.11159926208689 0.356662865835777 0.972468898553656 0.4 10.1 10 1 increased red blood cell distribution width 0.11159926208689 0.356662865835777 0.972468898553656 0.4 10.1 10 1 decreased bone volume 0.11159926208689 0.356662865835777 0.972468898553656 0.4 10.1 10 1 abnormal optic cup morphology 0.134817331569617 0.402359554617639 0.972468898553656 0.4 10.1 10 1 decreased chondrocyte number 0.253578041702157 0.558314124616683 0.972468898553656 0.4 10.1 10 1 macrocytosis 0.253578041702157 0.558314124616683 0.972468898553656 0.4 10.1 10 1 abnormal pup retrieval 0.253578041702157 0.558314124616683 0.972468898553656 0.4 10.1 10 1 abnormal seizure response to electrical stimulation 0.253578041702157 0.558314124616683 0.972468898553656 0.4 10.1 10 1 abnormal respiratory system morphology 0.253578041702157 0.558314124616683 0.972468898553656 0.4 10.1 10 1 abnormal cricoid cartilage morphology 0.253578041702157 0.558314124616683 0.972468898553656 0.4 10.1 10 1 altered righting response 0.253578041702157 0.558314124616683 0.972468898553656 0.4 10.1 10 1 abnormal glial cell morphology 0.253578041702157 0.558314124616683 0.972468898553656 0.4 10.1 10 1 abnormal ear development 0.253578041702157 0.558314124616683 0.972468898553656 0.4 10.1 10 1 abnormal placenta size 0.253578041702157 0.558314124616683 0.972468898553656 0.4 10.1 10 1 abnormal microglial cell activation 0.253578041702157 0.558314124616683 0.972468898553656 0.4 10.1 10 1 decreased trabecular bone mass 0.253578041702157 0.558314124616683 0.972468898553656 0.4 10.1 10 1 heterochrony 0.253578041702157 0.558314124616683 0.972468898553656 0.4 10.1 10 1 increased body weight 0.000424400360001465 0.0072182523172675 0.965956830036556 0.397321428571429 10.1 10 1 abnormal hair follicle morphology 0.0470590991229297 0.222335249892284 0.964750891422278 0.396825396825397 10.1 10 1 abnormal placenta development 0.0660043864337058 0.273643185423072 0.963294663661641 0.39622641509434 10.1 10 1 overriding aortic valve 0.0785049924978654 0.290611309859591 0.962339014193722 0.395833333333333 10.1 10 1 abnormal lymph node morphology 0.0785049924978654 0.290611309859591 0.962339014193722 0.395833333333333 10.1 10 1 abnormal intestinal mucosa morphology 0.0937121923053751 0.309368385347871 0.961161120663497 0.395348837209302 10.1 10 1 increased circulating alkaline phosphatase level 0.00293931077196204 0.0316516690270804 0.960463109682624 0.395061728395062 10.1 10 1 abnormal axial skeleton morphology 0.0341840500289463 0.172920331348175 0.959673255151634 0.394736842105263 10.1 10 1 abnormal frontal bone morphology 0.112364536439913 0.356662865835777 0.959673255151634 0.394736842105263 10.1 10 1 corneal opacity 0.0402492268650078 0.199425034961868 0.958772153503605 0.394366197183099 10.1 10 1 decreased body length 0.000161851047221776 0.00339750616003518 0.958272272297399 0.394160583941606 10.1 10 1 abnormal tooth development 0.135488023833393 0.402359554617639 0.957734521302843 0.393939393939394 10.1 10 1 abnormal epidermis stratum basale morphology 0.135488023833393 0.402359554617639 0.957734521302843 0.393939393939394 10.1 10 1 decreased rib number 0.0249941895394707 0.14259747171786 0.956078973297134 0.393258426966292 10.1 10 1 abnormal jaw morphology 0.164570038267253 0.453844756307973 0.955103382508055 0.392857142857143 10.1 10 1 increased circulating luteinizing hormone level 0.164570038267253 0.453844756307973 0.955103382508055 0.392857142857143 10.1 10 1 absent corpus callosum 0.164570038267253 0.453844756307973 0.955103382508055 0.392857142857143 10.1 10 1 enhanced coordination 0.164570038267253 0.453844756307973 0.955103382508055 0.392857142857143 10.1 10 1 enlarged heart 0.000606483789947804 0.00970179053051552 0.953606355262745 0.392241379310345 10.1 10 1 abnormal cued conditioning behavior 0.078999091079387 0.290611309859591 0.953400880934957 0.392156862745098 10.1 10 1 hydroencephaly 0.013554323019929 0.0927892798041066 0.951328270324229 0.391304347826087 10.1 10 1 abnormal pulmonary artery morphology 0.201898804747494 0.49823504793006 0.951328270324229 0.391304347826087 10.1 10 1 abnormal innervation pattern to muscle 0.201898804747494 0.49823504793006 0.951328270324229 0.391304347826087 10.1 10 1 blistering 0.201898804747494 0.49823504793006 0.951328270324229 0.391304347826087 10.1 10 1 abnormal circulating insulin level 0.201898804747494 0.49823504793006 0.951328270324229 0.391304347826087 10.1 10 1 failure of embryo implantation 0.201898804747494 0.49823504793006 0.951328270324229 0.391304347826087 10.1 10 1 pancreas inflammation 0.201898804747494 0.49823504793006 0.951328270324229 0.391304347826087 10.1 10 1 abnormal cochlear ganglion morphology 0.201898804747494 0.49823504793006 0.951328270324229 0.391304347826087 10.1 10 1 abnormal sacral vertebrae morphology 0.201898804747494 0.49823504793006 0.951328270324229 0.391304347826087 10.1 10 1 increased susceptibility to age related obesity 0.201898804747494 0.49823504793006 0.951328270324229 0.391304347826087 10.1 10 1 decreased epididymis weight 0.201898804747494 0.49823504793006 0.951328270324229 0.391304347826087 10.1 10 1 abnormal regulatory T cell physiology 0.201898804747494 0.49823504793006 0.951328270324229 0.391304347826087 10.1 10 1 abnormal lens development 0.201898804747494 0.49823504793006 0.951328270324229 0.391304347826087 10.1 10 1 obese 0.0407803491681139 0.201571040584227 0.947209966123691 0.38961038961039 10.1 10 1 decreased bone mineral content 0.00148484934223642 0.0189564437297942 0.946754576716901 0.389423076923077 10.1 10 1 abnormal osteoblast physiology 0.0792994777544811 0.290611309859591 0.945455873593833 0.388888888888889 10.1 10 1 impaired wound healing 0.135648158444341 0.402359554617639 0.945455873593833 0.388888888888889 10.1 10 1 abnormal reflex 0.135648158444341 0.402359554617639 0.945455873593833 0.388888888888889 10.1 10 1 abnormal retinal blood vessel morphology 0.135648158444341 0.402359554617639 0.945455873593833 0.388888888888889 10.1 10 1 underdeveloped hair follicles 0.251313376914538 0.558314124616683 0.945455873593833 0.388888888888889 10.1 10 1 cortical renal glomerulopathies 0.251313376914538 0.558314124616683 0.945455873593833 0.388888888888889 10.1 10 1 abnormal radius morphology 0.251313376914538 0.558314124616683 0.945455873593833 0.388888888888889 10.1 10 1 abnormal mammary gland morphology 0.251313376914538 0.558314124616683 0.945455873593833 0.388888888888889 10.1 10 1 absent spleen 0.251313376914538 0.558314124616683 0.945455873593833 0.388888888888889 10.1 10 1 eye inflammation 0.251313376914538 0.558314124616683 0.945455873593833 0.388888888888889 10.1 10 1 abnormal redox activity 0.251313376914538 0.558314124616683 0.945455873593833 0.388888888888889 10.1 10 1 increased effector memory CD4-positive, alpha-beta T cell number 0.251313376914538 0.558314124616683 0.945455873593833 0.388888888888889 10.1 10 1 abnormal metanephric mesenchyme morphology 0.251313376914538 0.558314124616683 0.945455873593833 0.388888888888889 10.1 10 1 decreased fluid intake 0.251313376914538 0.558314124616683 0.945455873593833 0.388888888888889 10.1 10 1 increased total body fat amount 0.0101562812369842 0.0739757758551177 0.943439976208771 0.388059701492537 10.1 10 1 absent mature ovarian follicles 0.164272028717125 0.453844756307973 0.941098934084184 0.387096774193548 10.1 10 1 autoimmune response 0.164272028717125 0.453844756307973 0.941098934084184 0.387096774193548 10.1 10 1 teratozoospermia 0.034970190866161 0.176446956956543 0.939316549739327 0.386363636363636 10.1 10 1 muscular atrophy 0.112806001962449 0.356662865835777 0.939316549739327 0.386363636363636 10.1 10 1 abnormal blood homeostasis 0.0187652964576748 0.117578526293366 0.938347182814932 0.385964912280702 10.1 10 1 failure of heart looping 0.135411447478403 0.402359554617639 0.935066248609285 0.384615384615385 10.1 10 1 abnormal tectorial membrane morphology 0.200658138977402 0.49823504793006 0.935066248609285 0.384615384615385 10.1 10 1 abnormal nerve conduction 0.200658138977402 0.49823504793006 0.935066248609285 0.384615384615385 10.1 10 1 abnormal membranous labyrinth morphology 0.320187393601852 0.584179409504396 0.935066248609285 0.384615384615385 10.1 10 1 absent myocardial trabeculae 0.320187393601852 0.584179409504396 0.935066248609285 0.384615384615385 10.1 10 1 increased foot pad pigmentation 0.320187393601852 0.584179409504396 0.935066248609285 0.384615384615385 10.1 10 1 abnormal grip strength 0.320187393601852 0.584179409504396 0.935066248609285 0.384615384615385 10.1 10 1 abnormal digestion 0.320187393601852 0.584179409504396 0.935066248609285 0.384615384615385 10.1 10 1 abnormal soleus morphology 0.320187393601852 0.584179409504396 0.935066248609285 0.384615384615385 10.1 10 1 anal atresia 0.320187393601852 0.584179409504396 0.935066248609285 0.384615384615385 10.1 10 1 absent lateral semicircular canal 0.320187393601852 0.584179409504396 0.935066248609285 0.384615384615385 10.1 10 1 abnormal insulin secretion 0.320187393601852 0.584179409504396 0.935066248609285 0.384615384615385 10.1 10 1 small otic vesicle 0.320187393601852 0.584179409504396 0.935066248609285 0.384615384615385 10.1 10 1 decreased endocochlear potential 0.320187393601852 0.584179409504396 0.935066248609285 0.384615384615385 10.1 10 1 abnormal hair follicle inner root sheath morphology 0.320187393601852 0.584179409504396 0.935066248609285 0.384615384615385 10.1 10 1 muscular ventricular septal defect 0.0794267860878902 0.290611309859591 0.931949361113921 0.383333333333333 10.1 10 1 increased systemic arterial blood pressure 0.11261475436328 0.356662865835777 0.931087243296054 0.382978723404255 10.1 10 1 abnormal retinal photoreceptor morphology 0.16348110783031 0.453102234794313 0.929565858911583 0.382352941176471 10.1 10 1 overexpanded pulmonary alveoli 0.16348110783031 0.453102234794313 0.929565858911583 0.382352941176471 10.1 10 1 abnormal vision 0.16348110783031 0.453102234794313 0.929565858911583 0.382352941176471 10.1 10 1 increased circulating calcium level 0.0942644042827724 0.310573120070724 0.928265766801217 0.381818181818182 10.1 10 1 abnormal T-helper 2 physiology 0.0942644042827724 0.310573120070724 0.928265766801217 0.381818181818182 10.1 10 1 increased heart weight 0.0139430823156758 0.094505224142353 0.926993734232802 0.381294964028777 10.1 10 1 increased circulating insulin level 0.00890178725107179 0.0680389878130877 0.926884418933954 0.38125 10.1 10 1 abnormal retina morphology 0.00318945264251644 0.0334637270396888 0.926160855765387 0.380952380952381 10.1 10 1 arrest of spermatogenesis 0.0482815562461616 0.226604473891183 0.926160855765387 0.380952380952381 10.1 10 1 abnormal reproductive system morphology 0.13486343603499 0.402359554617639 0.926160855765387 0.380952380952381 10.1 10 1 decreased cochlear outer hair cell number 0.248071004061806 0.558314124616683 0.926160855765387 0.380952380952381 10.1 10 1 abnormal stapes morphology 0.248071004061806 0.558314124616683 0.926160855765387 0.380952380952381 10.1 10 1 decreased vocalization 0.248071004061806 0.558314124616683 0.926160855765387 0.380952380952381 10.1 10 1 abnormal digestive system physiology 0.112214713238811 0.356662865835777 0.923845453625974 0.38 10.1 10 1 abnormal spermiogenesis 0.0939618444648945 0.309986854252553 0.922168783111226 0.379310344827586 10.1 10 1 abnormal middle ear morphology 0.198839245290538 0.49823504793006 0.922168783111226 0.379310344827586 10.1 10 1 abnormal parietal bone morphology 0.198839245290538 0.49823504793006 0.922168783111226 0.379310344827586 10.1 10 1 decreased retinal photoreceptor cell number 0.198839245290538 0.49823504793006 0.922168783111226 0.379310344827586 10.1 10 1 polychromatophilia 0.198839245290538 0.49823504793006 0.922168783111226 0.379310344827586 10.1 10 1 increased retinal apoptosis 0.198839245290538 0.49823504793006 0.922168783111226 0.379310344827586 10.1 10 1 abnormal breathing pattern 0.162323283737982 0.452237011694502 0.919903012145351 0.378378378378378 10.1 10 1 skin inflammation 0.162323283737982 0.452237011694502 0.919903012145351 0.378378378378378 10.1 10 1 abnormal excitatory postsynaptic potential 0.0565931857414526 0.248062642346896 0.919101702901322 0.378048780487805 10.1 10 1 abnormal ectoderm development 0.134069562716918 0.402359554617639 0.918442848634009 0.377777777777778 10.1 10 1 albuminuria 0.134069562716918 0.402359554617639 0.918442848634009 0.377777777777778 10.1 10 1 abnormal mesoderm development 0.111643186284316 0.356662865835777 0.917423489201563 0.377358490566038 10.1 10 1 abnormal maternal nurturing 0.0935360195246323 0.308991830766963 0.916671502735004 0.377049180327869 10.1 10 1 abnormal long bone morphology 0.0935360195246323 0.308991830766963 0.916671502735004 0.377049180327869 10.1 10 1 abnormal male meiosis 0.0935360195246323 0.308991830766963 0.916671502735004 0.377049180327869 10.1 10 1 decreased spleen weight 0.0787370817904897 0.290611309859591 0.91609388994185 0.376811594202899 10.1 10 1 circling 0.0563925217851204 0.247777856714323 0.915264845697559 0.376470588235294 10.1 10 1 abnormal vertebrae morphology 0.0348291054672216 0.175913502232921 0.914477633961007 0.376146788990826 10.1 10 1 abnormal skin pigmentation 0.160890088193671 0.449931528253801 0.911689592394053 0.375 10.1 10 1 abnormal digestive system morphology 0.244277212002757 0.558314124616683 0.911689592394053 0.375 10.1 10 1 abnormal foregut morphology 0.244277212002757 0.558314124616683 0.911689592394053 0.375 10.1 10 1 increased stereotypic behavior 0.244277212002757 0.558314124616683 0.911689592394053 0.375 10.1 10 1 decreased circulating HDL cholesterol level 0.0253952482295526 0.14259747171786 0.911689592394053 0.375 10.1 10 1 absent mandible 0.312285949843128 0.584179409504396 0.911689592394053 0.375 10.1 10 1 vasculature congestion 0.312285949843128 0.584179409504396 0.911689592394053 0.375 10.1 10 1 delayed hair appearance 0.312285949843128 0.584179409504396 0.911689592394053 0.375 10.1 10 1 abnormal meiosis 0.312285949843128 0.584179409504396 0.911689592394053 0.375 10.1 10 1 abnormal olfaction 0.312285949843128 0.584179409504396 0.911689592394053 0.375 10.1 10 1 decreased circulating prolactin level 0.312285949843128 0.584179409504396 0.911689592394053 0.375 10.1 10 1 impaired behavioral response to addictive substance 0.312285949843128 0.584179409504396 0.911689592394053 0.375 10.1 10 1 impaired somite development 0.312285949843128 0.584179409504396 0.911689592394053 0.375 10.1 10 1 decreased midbrain size 0.312285949843128 0.584179409504396 0.911689592394053 0.375 10.1 10 1 maternal effect 0.0923876482505031 0.305807418527114 0.907153823277664 0.373134328358209 10.1 10 1 abnormal gastrulation 0.13193648889597 0.399260360253923 0.905730836888209 0.372549019607843 10.1 10 1 abnormal cervical vertebrae morphology 0.13193648889597 0.399260360253923 0.905730836888209 0.372549019607843 10.1 10 1 abnormal gluconeogenesis 0.13193648889597 0.399260360253923 0.905730836888209 0.372549019607843 10.1 10 1 increased kidney weight 0.13193648889597 0.399260360253923 0.905730836888209 0.372549019607843 10.1 10 1 holoprosencephaly 0.19413856213324 0.49823504793006 0.903006834371252 0.371428571428571 10.1 10 1 impaired adaptive thermogenesis 0.19413856213324 0.49823504793006 0.903006834371252 0.371428571428571 10.1 10 1 abnormal neuronal precursor proliferation 0.130668897184219 0.397844408501524 0.90043416532746 0.37037037037037 10.1 10 1 rectal prolapse 0.240173542594417 0.558314124616683 0.90043416532746 0.37037037037037 10.1 10 1 wrinkled skin 0.240173542594417 0.558314124616683 0.90043416532746 0.37037037037037 10.1 10 1 decreased susceptibility to pharmacologically induced seizures 0.240173542594417 0.558314124616683 0.90043416532746 0.37037037037037 10.1 10 1 decreased bone ossification 0.240173542594417 0.558314124616683 0.90043416532746 0.37037037037037 10.1 10 1 delayed wound healing 0.157452227145327 0.442806574362918 0.898476699750661 0.369565217391304 10.1 10 1 abnormal circulating amino acid level 0.129303261747058 0.393927573295538 0.895695038141526 0.368421052631579 10.1 10 1 hyporesponsive to tactile stimuli 0.191465886328522 0.49823504793006 0.895695038141526 0.368421052631579 10.1 10 1 abnormal nail morphology 0.304417306053946 0.579814738751295 0.895695038141526 0.368421052631579 10.1 10 1 short vibrissae 0.304417306053946 0.579814738751295 0.895695038141526 0.368421052631579 10.1 10 1 abnormal long term depression 0.304417306053946 0.579814738751295 0.895695038141526 0.368421052631579 10.1 10 1 decreased chemically-elicited antinociception 0.304417306053946 0.579814738751295 0.895695038141526 0.368421052631579 10.1 10 1 abnormal nasal septum morphology 0.304417306053946 0.579814738751295 0.895695038141526 0.368421052631579 10.1 10 1 osteoarthritis 0.304417306053946 0.579814738751295 0.895695038141526 0.368421052631579 10.1 10 1 abnormal cochlear inner hair cell morphology 0.304417306053946 0.579814738751295 0.895695038141526 0.368421052631579 10.1 10 1 increased circulating VLDL cholesterol level 0.304417306053946 0.579814738751295 0.895695038141526 0.368421052631579 10.1 10 1 embryonic lethality between implantation and somite formation, incomplete penetrance 0.304417306053946 0.579814738751295 0.895695038141526 0.368421052631579 10.1 10 1 abnormal retinal pigmentation 0.0754700571248701 0.290611309859591 0.894224274532098 0.367816091954023 10.1 10 1 increased circulating LDL cholesterol level 0.155537793014956 0.438215131485303 0.893083682345195 0.36734693877551 10.1 10 1 microphthalmia 0.027697295974749 0.1472158626863 0.88984082220596 0.366013071895425 10.1 10 1 increased tumor growth/size 0.188667805875492 0.49823504793006 0.889453260872247 0.365853658536585 10.1 10 1 lethality at weaning, incomplete penetrance 0.188667805875492 0.49823504793006 0.889453260872247 0.365853658536585 10.1 10 1 abnormal snout morphology 0.153536317182514 0.435486418462376 0.888312936178821 0.365384615384615 10.1 10 1 increased circulating cholesterol level 0.0228021400485921 0.135694553518835 0.884062635048779 0.363636363636364 10.1 10 1 embryonic lethality, incomplete penetrance 0.185788418978092 0.49823504793006 0.884062635048779 0.363636363636364 10.1 10 1 dextrocardia 0.231560288110811 0.558314124616683 0.884062635048779 0.363636363636364 10.1 10 1 single kidney 0.231560288110811 0.558314124616683 0.884062635048779 0.363636363636364 10.1 10 1 diarrhea 0.231560288110811 0.558314124616683 0.884062635048779 0.363636363636364 10.1 10 1 abnormal facial nerve morphology 0.296742305741741 0.567150584350811 0.884062635048779 0.363636363636364 10.1 10 1 intracerebral hemorrhage 0.296742305741741 0.567150584350811 0.884062635048779 0.363636363636364 10.1 10 1 increased coping response 0.296742305741741 0.567150584350811 0.884062635048779 0.363636363636364 10.1 10 1 aphakia 0.296742305741741 0.567150584350811 0.884062635048779 0.363636363636364 10.1 10 1 parakeratosis 0.296742305741741 0.567150584350811 0.884062635048779 0.363636363636364 10.1 10 1 abnormal social investigation 0.102386208650739 0.334452651370603 0.881299939314251 0.3625 10.1 10 1 pulmonary hypoplasia 0.182860128388488 0.493345519920134 0.879360174224051 0.361702127659574 10.1 10 1 abnormal digit morphology 0.121606105693611 0.37507152872022 0.877923311194273 0.361111111111111 10.1 10 1 abnormal systemic arterial blood pressure 0.227198355522618 0.550030082104634 0.877923311194273 0.361111111111111 10.1 10 1 abnormal limb bone morphology 0.227198355522618 0.550030082104634 0.877923311194273 0.361111111111111 10.1 10 1 testicular atrophy 0.179907025389037 0.485905239582224 0.875222008698291 0.36 10.1 10 1 abnormal axon extension 0.179907025389037 0.485905239582224 0.875222008698291 0.36 10.1 10 1 ruffled hair 0.289322083643726 0.558314124616683 0.875222008698291 0.36 10.1 10 1 abnormal thyroid gland morphology 0.289322083643726 0.558314124616683 0.875222008698291 0.36 10.1 10 1 decreased placenta weight 0.289322083643726 0.558314124616683 0.875222008698291 0.36 10.1 10 1 abnormal vertebrae development 0.289322083643726 0.558314124616683 0.875222008698291 0.36 10.1 10 1 small lens 0.222856372084589 0.54004405802281 0.872728498701999 0.358974358974359 10.1 10 1 abnormal neuron differentiation 0.0784562651416265 0.290611309859591 0.86827580228005 0.357142857142857 10.1 10 1 abnormal interparietal bone morphology 0.387877876900982 0.670032096382772 0.86827580228005 0.357142857142857 10.1 10 1 midline facial cleft 0.387877876900982 0.670032096382772 0.86827580228005 0.357142857142857 10.1 10 1 abnormal vasoconstriction 0.387877876900982 0.670032096382772 0.86827580228005 0.357142857142857 10.1 10 1 megacephaly 0.387877876900982 0.670032096382772 0.86827580228005 0.357142857142857 10.1 10 1 irregularly shaped pupil 0.387877876900982 0.670032096382772 0.86827580228005 0.357142857142857 10.1 10 1 abnormal sagittal suture morphology 0.387877876900982 0.670032096382772 0.86827580228005 0.357142857142857 10.1 10 1 enlarged stomach 0.387877876900982 0.670032096382772 0.86827580228005 0.357142857142857 10.1 10 1 abnormal pancreas development 0.387877876900982 0.670032096382772 0.86827580228005 0.357142857142857 10.1 10 1 split sternum 0.387877876900982 0.670032096382772 0.86827580228005 0.357142857142857 10.1 10 1 abnormal renal reabsorbtion 0.387877876900982 0.670032096382772 0.86827580228005 0.357142857142857 10.1 10 1 abnormal thoracic vertebrae morphology 0.171058583160215 0.471477258294774 0.865332494475711 0.355932203389831 10.1 10 1 decreased insulin secretion 0.111735120377836 0.356662865835777 0.864416798714361 0.355555555555556 10.1 10 1 abnormal autopod morphology 0.214322960363567 0.519618288405822 0.864416798714361 0.355555555555556 10.1 10 1 abnormal podocyte morphology 0.275302458034426 0.558314124616683 0.862674022910502 0.354838709677419 10.1 10 1 abnormal inhibitory postsynaptic currents 0.162424627854309 0.452237011694502 0.858060792841461 0.352941176470588 10.1 10 1 increased incidence of corneal inflammation 0.37279513121746 0.646672167994026 0.858060792841461 0.352941176470588 10.1 10 1 decreased vasoconstriction 0.37279513121746 0.646672167994026 0.858060792841461 0.352941176470588 10.1 10 1 nephrocalcinosis 0.37279513121746 0.646672167994026 0.858060792841461 0.352941176470588 10.1 10 1 abnormal duodenum morphology 0.37279513121746 0.646672167994026 0.858060792841461 0.352941176470588 10.1 10 1 abnormal testis development 0.37279513121746 0.646672167994026 0.858060792841461 0.352941176470588 10.1 10 1 abnormal embryonic-extraembryonic boundary morphology 0.37279513121746 0.646672167994026 0.858060792841461 0.352941176470588 10.1 10 1 coloboma 0.37279513121746 0.646672167994026 0.858060792841461 0.352941176470588 10.1 10 1 abnormal cell cytoskeleton morphology 0.37279513121746 0.646672167994026 0.858060792841461 0.352941176470588 10.1 10 1 increased circulating HDL cholesterol level 0.103669056871285 0.338083354080179 0.856698791582983 0.352380952380952 10.1 10 1 decreased circulating chloride level 0.262339019405962 0.558314124616683 0.854195654134968 0.351351351351351 10.1 10 1 increased insulin secretion 0.262339019405962 0.558314124616683 0.854195654134968 0.351351351351351 10.1 10 1 increased mammary adenocarcinoma incidence 0.359413996022322 0.626080052594906 0.850910286234449 0.35 10.1 10 1 abnormal hair texture 0.359413996022322 0.626080052594906 0.850910286234449 0.35 10.1 10 1 spleen atrophy 0.359413996022322 0.626080052594906 0.850910286234449 0.35 10.1 10 1 abnormal male reproductive system physiology 0.359413996022322 0.626080052594906 0.850910286234449 0.35 10.1 10 1 nuclear cataracts 0.359413996022322 0.626080052594906 0.850910286234449 0.35 10.1 10 1 decreased muscle cell glucose uptake 0.359413996022322 0.626080052594906 0.850910286234449 0.35 10.1 10 1 abnormal tail morphology 0.186911595365399 0.49823504793006 0.847226691921746 0.348484848484849 10.1 10 1 abnormal Wolffian duct morphology 0.347325506272007 0.606935157605632 0.845625129177092 0.347826086956522 10.1 10 1 abnormal eye electrophysiology 0.106952507843495 0.344617050855819 0.843877969819289 0.347107438016529 10.1 10 1 decreased circulating creatinine level 0.239175862586587 0.558314124616683 0.843467922214906 0.346938775510204 10.1 10 1 small seminal vesicle 0.33626181905531 0.588221712306669 0.841559623748356 0.346153846153846 10.1 10 1 abnormal Mullerian duct morphology 0.33626181905531 0.588221712306669 0.841559623748356 0.346153846153846 10.1 10 1 abnormal head morphology 0.228774298671764 0.553575941581724 0.83985950329634 0.345454545454545 10.1 10 1 abnormal circulating glucose level 0.326036670575633 0.584179409504396 0.838335257373842 0.344827586206897 10.1 10 1 decreased bone strength 0.326036670575633 0.584179409504396 0.838335257373842 0.344827586206897 10.1 10 1 increased fatty acid level 0.316514502142495 0.584179409504396 0.835715459694548 0.34375 10.1 10 1 abnormal serotonin level 0.316514502142495 0.584179409504396 0.835715459694548 0.34375 10.1 10 1 scaly skin 0.29125136503829 0.558314124616683 0.830156376814097 0.341463414634146 10.1 10 1 short femur 0.181927471893709 0.49109559016343 0.82880872035823 0.340909090909091 10.1 10 1 increased circulating glucose level 0.117988641562382 0.364139883233779 0.827633105152048 0.340425531914894 10.1 10 1 increased body length 0.269708293870173 0.558314124616683 0.826598563770608 0.34 10.1 10 1 increased hemoglobin content 0.250892730144284 0.558314124616683 0.824126185214963 0.338983050847458 10.1 10 1 abnormal neuromuscular synapse morphology 0.253611819866061 0.558314124616683 0.810390748794714 0.333333333333333 10.1 10 1 polyphagia 0.293718819366353 0.562452319610319 0.810390748794714 0.333333333333333 10.1 10 1 abnormal aorta morphology 0.358991609158336 0.626080052594906 0.810390748794714 0.333333333333333 10.1 10 1 abnormal skeleton physiology 0.358991609158336 0.626080052594906 0.810390748794714 0.333333333333333 10.1 10 1 abnormal single cell response 0.384305957285757 0.666174960800223 0.810390748794714 0.333333333333333 10.1 10 1 ocular hypertelorism 0.398849653406632 0.686838707406713 0.810390748794714 0.333333333333333 10.1 10 1 abnormal vasodilation 0.398849653406632 0.686838707406713 0.810390748794714 0.333333333333333 10.1 10 1 apnea 0.398849653406632 0.686838707406713 0.810390748794714 0.333333333333333 10.1 10 1 abnormal impulse conducting system conduction 0.398849653406632 0.686838707406713 0.810390748794714 0.333333333333333 10.1 10 1 abnormal retinal ganglion layer morphology 0.398849653406632 0.686838707406713 0.810390748794714 0.333333333333333 10.1 10 1 decreased fatty acid level 0.398849653406632 0.686838707406713 0.810390748794714 0.333333333333333 10.1 10 1 increased body temperature 0.398849653406632 0.686838707406713 0.810390748794714 0.333333333333333 10.1 10 1 abnormal associative learning 0.415085492002581 0.708422066110751 0.810390748794714 0.333333333333333 10.1 10 1 increased keratinocyte proliferation 0.415085492002581 0.708422066110751 0.810390748794714 0.333333333333333 10.1 10 1 abnormal iron level 0.433536008368922 0.722076210791895 0.810390748794714 0.333333333333333 10.1 10 1 decreased heart rate variability 0.433536008368922 0.722076210791895 0.810390748794714 0.333333333333333 10.1 10 1 long tibia 0.433536008368922 0.722076210791895 0.810390748794714 0.333333333333333 10.1 10 1 abnormal sperm axoneme morphology 0.433536008368922 0.722076210791895 0.810390748794714 0.333333333333333 10.1 10 1 atrioventricular block 0.433536008368922 0.722076210791895 0.810390748794714 0.333333333333333 10.1 10 1 abnormal eye physiology 0.279179454776259 0.558314124616683 0.810390748794714 0.333333333333333 10.1 10 1 delayed eyelid opening 0.371102723983177 0.645537081054652 0.810390748794714 0.333333333333333 10.1 10 1 abnormal pain threshold 0.371102723983177 0.645537081054652 0.810390748794714 0.333333333333333 10.1 10 1 enhanced paired-pulse facilitation 0.371102723983177 0.645537081054652 0.810390748794714 0.333333333333333 10.1 10 1 abnormal microglial cell physiology 0.371102723983177 0.645537081054652 0.810390748794714 0.333333333333333 10.1 10 1 abnormal fontanelle morphology 0.455027794500394 0.734988077155669 0.810390748794714 0.333333333333333 10.1 10 1 interdigital webbing 0.455027794500394 0.734988077155669 0.810390748794714 0.333333333333333 10.1 10 1 placental labyrinth hypoplasia 0.455027794500394 0.734988077155669 0.810390748794714 0.333333333333333 10.1 10 1 joint inflammation 0.455027794500394 0.734988077155669 0.810390748794714 0.333333333333333 10.1 10 1 arthritis 0.455027794500394 0.734988077155669 0.810390748794714 0.333333333333333 10.1 10 1 increased alcohol consumption 0.455027794500394 0.734988077155669 0.810390748794714 0.333333333333333 10.1 10 1 abnormal branching involved in lung morphogenesis 0.455027794500394 0.734988077155669 0.810390748794714 0.333333333333333 10.1 10 1 abnormal suckling behavior 0.248636590619996 0.558314124616683 0.801181763012956 0.329545454545455 10.1 10 1 dehydration 0.28607671970944 0.558314124616683 0.798813738097646 0.328571428571429 10.1 10 1 abnormal lens morphology 0.205565826869475 0.498629931094898 0.797728393344796 0.328125 10.1 10 1 increased percent body fat/body weight 0.334379702943666 0.58534096486444 0.794806311317892 0.326923076923077 10.1 10 1 decreased urine osmolality 0.343956139127108 0.601258535543698 0.793852162084617 0.326530612244898 10.1 10 1 perinatal lethality 0.376428098160961 0.652746527832269 0.790130980074846 0.325 10.1 10 1 abnormal nervous system development 0.402177237412239 0.69208984992248 0.78655572677134 0.323529411764706 10.1 10 1 decreased osteoblast cell number 0.402177237412239 0.69208984992248 0.78655572677134 0.323529411764706 10.1 10 1 abnormal eyelid morphology 0.416721898244487 0.710483702455903 0.78424911173682 0.32258064516129 10.1 10 1 abnormal body temperature homeostasis 0.416721898244487 0.710483702455903 0.78424911173682 0.32258064516129 10.1 10 1 decreased thymus weight 0.416721898244487 0.710483702455903 0.78424911173682 0.32258064516129 10.1 10 1 syndactyly 0.347967104856672 0.607842818350401 0.782919875954215 0.322033898305085 10.1 10 1 abnormal circulating cholesterol level 0.432683547316611 0.721864737726406 0.781448222052045 0.321428571428571 10.1 10 1 abnormal retinal inner nuclear layer morphology 0.432683547316611 0.721864737726406 0.781448222052045 0.321428571428571 10.1 10 1 abnormal heart left ventricle morphology 0.341487173923998 0.597152439462879 0.776624467594934 0.319444444444444 10.1 10 1 abnormal tibia morphology 0.390458820156169 0.674022425495122 0.775906036080045 0.319148936170213 10.1 10 1 abnormal innervation 0.390458820156169 0.674022425495122 0.775906036080045 0.319148936170213 10.1 10 1 abnormal photoreceptor outer segment morphology 0.402782446991588 0.692503143783477 0.773554805667681 0.318181818181818 10.1 10 1 increased body size 0.470312312257639 0.737521500066449 0.773554805667681 0.318181818181818 10.1 10 1 decreased airway responsiveness 0.470312312257639 0.737521500066449 0.773554805667681 0.318181818181818 10.1 10 1 abnormal retinal outer plexiform layer morphology 0.470312312257639 0.737521500066449 0.773554805667681 0.318181818181818 10.1 10 1 abnormal temporal bone morphology 0.470312312257639 0.737521500066449 0.773554805667681 0.318181818181818 10.1 10 1 abnormal sperm midpiece morphology 0.470312312257639 0.737521500066449 0.773554805667681 0.318181818181818 10.1 10 1 decreased total retina thickness 0.430167459776474 0.718148695432201 0.767738604121308 0.315789473684211 10.1 10 1 decreased threshold for auditory brainstem response 0.430167459776474 0.718148695432201 0.767738604121308 0.315789473684211 10.1 10 1 abnormal ear morphology 0.493129255591219 0.737521500066449 0.767738604121308 0.315789473684211 10.1 10 1 abnormal neurotransmitter level 0.493129255591219 0.737521500066449 0.767738604121308 0.315789473684211 10.1 10 1 decreased germ cell number 0.493129255591219 0.737521500066449 0.767738604121308 0.315789473684211 10.1 10 1 abnormal neural crest cell migration 0.493129255591219 0.737521500066449 0.767738604121308 0.315789473684211 10.1 10 1 increased susceptibility to ischemic brain injury 0.493129255591219 0.737521500066449 0.767738604121308 0.315789473684211 10.1 10 1 eyelids fail to open 0.493129255591219 0.737521500066449 0.767738604121308 0.315789473684211 10.1 10 1 abnormal hair shaft morphology 0.427148206010272 0.713587080221996 0.759741326995044 0.3125 10.1 10 1 abnormal long term potentiation 0.462270714654483 0.737521500066449 0.759741326995044 0.3125 10.1 10 1 abnormal hair follicle orientation 0.519910451162788 0.761199086090309 0.759741326995044 0.3125 10.1 10 1 disorganized retinal layers 0.519910451162788 0.761199086090309 0.759741326995044 0.3125 10.1 10 1 abnormal intestinal absorption 0.519910451162788 0.761199086090309 0.759741326995044 0.3125 10.1 10 1 intraventricular hemorrhage 0.519910451162788 0.761199086090309 0.759741326995044 0.3125 10.1 10 1 paternal imprinting 0.519910451162788 0.761199086090309 0.759741326995044 0.3125 10.1 10 1 decreased cochlear coiling 0.519910451162788 0.761199086090309 0.759741326995044 0.3125 10.1 10 1 abnormal pancreatic alpha cell morphology 0.519910451162788 0.761199086090309 0.759741326995044 0.3125 10.1 10 1 abnormal fertilization 0.519910451162788 0.761199086090309 0.759741326995044 0.3125 10.1 10 1 abnormal cartilage development 0.440884364655928 0.73406951611889 0.756364698875066 0.311111111111111 10.1 10 1 abnormal spinal nerve morphology 0.480674641850051 0.737521500066449 0.754501731636458 0.310344827586207 10.1 10 1 abnormal iris morphology 0.471414603291774 0.737521500066449 0.748052998887428 0.307692307692308 10.1 10 1 abnormal ureter morphology 0.501116581453901 0.741759890726914 0.748052998887428 0.307692307692308 10.1 10 1 abnormal Schwann cell morphology 0.501116581453901 0.741759890726914 0.748052998887428 0.307692307692308 10.1 10 1 increased liver weight 0.41458416781302 0.708052260511423 0.745927848322407 0.306818181818182 10.1 10 1 renal hypoplasia 0.48853297462426 0.737521500066449 0.742858186395154 0.305555555555556 10.1 10 1 abnormal food intake 0.451593097333018 0.734988077155669 0.739921988029956 0.304347826086957 10.1 10 1 abnormal carpal bone morphology 0.524119039876352 0.766683982177258 0.739921988029956 0.304347826086957 10.1 10 1 hypotension 0.524119039876352 0.766683982177258 0.739921988029956 0.304347826086957 10.1 10 1 abnormal ulna morphology 0.524119039876352 0.766683982177258 0.739921988029956 0.304347826086957 10.1 10 1 decreased food intake 0.446381460223808 0.734988077155669 0.738583973585055 0.30379746835443 10.1 10 1 absent vibrissae 0.507174673565851 0.750280702048798 0.736718862540649 0.303030303030303 10.1 10 1 decreased systemic arterial blood pressure 0.507174673565851 0.750280702048798 0.736718862540649 0.303030303030303 10.1 10 1 abnormal axon guidance 0.494892308714071 0.737521500066449 0.735005562860322 0.302325581395349 10.1 10 1 waved hair 0.550435795406461 0.801785856087825 0.729351673915242 0.3 10.1 10 1 increased urine glucose level 0.550435795406461 0.801785856087825 0.729351673915242 0.3 10.1 10 1 abnormal fibula morphology 0.550435795406461 0.801785856087825 0.729351673915242 0.3 10.1 10 1 abnormal optic stalk morphology 0.550435795406461 0.801785856087825 0.729351673915242 0.3 10.1 10 1 abnormal response to tactile stimuli 0.550435795406461 0.801785856087825 0.729351673915242 0.3 10.1 10 1 cataract 0.475705177354795 0.737521500066449 0.723323974130819 0.297520661157025 10.1 10 1 abnormal humerus morphology 0.530724682600825 0.776118546719314 0.722780938114204 0.297297297297297 10.1 10 1 abnormal brain commissure morphology 0.550300002156277 0.801785856087825 0.720347332261968 0.296296296296296 10.1 10 1 abnormal gametogenesis 0.533519024920273 0.779975653534634 0.718300890977133 0.295454545454545 10.1 10 1 decreased pancreatic beta cell number 0.550923605296522 0.801785856087825 0.715050660701218 0.294117647058824 10.1 10 1 abnormal urinary bladder morphology 0.581208501140007 0.828513551052016 0.715050660701218 0.294117647058824 10.1 10 1 abnormal vagus nerve morphology 0.581208501140007 0.828513551052016 0.715050660701218 0.294117647058824 10.1 10 1 abnormal cranial suture morphology 0.581208501140007 0.828513551052016 0.715050660701218 0.294117647058824 10.1 10 1 decreased growth hormone level 0.581208501140007 0.828513551052016 0.715050660701218 0.294117647058824 10.1 10 1 abnormal ductus venosus valve morphology 0.581208501140007 0.828513551052016 0.715050660701218 0.294117647058824 10.1 10 1 retinal degeneration 0.536693414012979 0.784385938517794 0.709091905195374 0.291666666666667 10.1 10 1 abnormal cardiovascular system morphology 0.553080537401323 0.801785856087825 0.709091905195374 0.291666666666667 10.1 10 1 abnormal inner cell mass apoptosis 0.575700551952119 0.821839381911562 0.709091905195374 0.291666666666667 10.1 10 1 abnormal lung saccule morphology 0.575700551952119 0.821839381911562 0.709091905195374 0.291666666666667 10.1 10 1 abnormal retinal outer nuclear layer morphology 0.571692440047783 0.816586244397852 0.703760387111199 0.289473684210526 10.1 10 1 abnormal eye development 0.587750644204575 0.837599385539318 0.69462064182404 0.285714285714286 10.1 10 1 abnormal mitotic spindle morphology 0.597346584092143 0.844981306755307 0.69462064182404 0.285714285714286 10.1 10 1 abnormal bile salt homeostasis 0.604575916768012 0.854964521296435 0.69462064182404 0.285714285714286 10.1 10 1 abnormal lens fiber morphology 0.611087304487643 0.863927064457523 0.685715248980142 0.282051282051282 10.1 10 1 abnormal crypts of Lieberkuhn morphology 0.616338843367186 0.865832294423688 0.68376719429554 0.28125 10.1 10 1 abnormal energy expenditure 0.624431640253394 0.865832294423688 0.68072822898756 0.28 10.1 10 1 impaired conditioned place preference behavior 0.624431640253394 0.865832294423688 0.68072822898756 0.28 10.1 10 1 abnormal stomach glandular epithelium morphology 0.63800561374427 0.865832294423688 0.675325623995595 0.277777777777778 10.1 10 1 delayed kidney development 0.63800561374427 0.865832294423688 0.675325623995595 0.277777777777778 10.1 10 1 abnormal epidermis stratum granulosum morphology 0.633292780224123 0.865832294423688 0.675325623995595 0.277777777777778 10.1 10 1 blepharoptosis 0.63800561374427 0.865832294423688 0.675325623995595 0.277777777777778 10.1 10 1 abnormal anterior eye segment morphology 0.63800561374427 0.865832294423688 0.675325623995595 0.277777777777778 10.1 10 1 abnormal glycogen homeostasis 0.63800561374427 0.865832294423688 0.675325623995595 0.277777777777778 10.1 10 1 stomach inflammation 0.641793038279607 0.865832294423688 0.670668205899073 0.275862068965517 10.1 10 1 abnormal pancreatic beta cell physiology 0.671280964529047 0.889617154643583 0.657073580103822 0.27027027027027 10.1 10 1 abnormal bone remodeling 0.695562055671306 0.919591078119784 0.643545594631096 0.264705882352941 10.1 10 1 abnormal optic vesicle formation 0.689747170227503 0.912145712887248 0.63978217010109 0.263157894736842 10.1 10 1 abnormal photoreceptor inner segment morphology 0.689747170227503 0.912145712887248 0.63978217010109 0.263157894736842 10.1 10 1 right-sided stomach 0.689747170227503 0.912145712887248 0.63978217010109 0.263157894736842 10.1 10 1 decreased neuronal precursor cell number 0.721670001588418 0.950129615952511 0.627399289389456 0.258064516129032 10.1 10 1 abnormal intestine physiology 0.721670001588418 0.950129615952511 0.627399289389456 0.258064516129032 10.1 10 1 increased susceptibility to weight loss 0.770283951433688 0.979091123756412 0.607793061596035 0.25 10.1 10 1 abnormal optic nerve morphology 0.823329397158735 1 0.578850534853367 0.238095238095238 10.1 10 1 abnormal heart looping 0.844202145134127 1 0.561039749165571 0.230769230769231 10.1 10 1 abnormal stomach morphology 0.813425618704464 1 0.561039749165571 0.230769230769231 10.1 10 1 abnormal phalanx morphology 0.867724616246154 1 0.557143639796366 0.229166666666667 10.1 10 1 abnormal retinal layer morphology 0.813308132523211 1 0.552539146905487 0.227272727272727 10.1 10 1 abnormal cranial ganglia morphology 0.842114972762245 1 0.548974378215774 0.225806451612903 10.1 10 1 abnormal nose morphology 0.842114972762245 1 0.548974378215774 0.225806451612903 10.1 10 1 cryptorchism 0.842487015570167 1 0.540260499196476 0.222222222222222 10.1 10 1 abnormal adaptive thermogenesis 6.21078537267698e-05 0.000903469509621871 1.63385093167702 1 11.2 11 2 pancreas cysts 0.000163653784410178 0.00210926833533843 1.63385093167702 1 11.2 11 2 increased neuronal precursor cell number 0.000163653784410178 0.00210926833533843 1.63385093167702 1 11.2 11 2 abnormal extraembryonic tissue physiology 0.000431205853950869 0.00480997561301698 1.63385093167702 1 11.2 11 2 abnormal kidney epithelium morphology 0.000431205853950869 0.00480997561301698 1.63385093167702 1 11.2 11 2 decreased white adipose tissue mass 0.000431205853950869 0.00480997561301698 1.63385093167702 1 11.2 11 2 broad head 0.00113611504299321 0.0103363201791581 1.63385093167702 1 11.2 11 2 abnormal brain ventricular system morphology 0.00113611504299321 0.0103363201791581 1.63385093167702 1 11.2 11 2 decreased mortality induced by ionizing radiation 0.00113611504299321 0.0103363201791581 1.63385093167702 1 11.2 11 2 decreased cardiomyocyte apoptosis 0.00113611504299321 0.0103363201791581 1.63385093167702 1 11.2 11 2 abnormal renal filtration rate 0.00113611504299321 0.0103363201791581 1.63385093167702 1 11.2 11 2 decreased DN2 thymocyte number 0.00113611504299321 0.0103363201791581 1.63385093167702 1 11.2 11 2 ductus venosus stenosis 0.00113611504299321 0.0103363201791581 1.63385093167702 1 11.2 11 2 decreased liver function 0.0029932227767783 0.0224943856714079 1.63385093167702 1 11.2 11 2 decreased prostate gland weight 0.0029932227767783 0.0224943856714079 1.63385093167702 1 11.2 11 2 myocardium hypoplasia 0.0029932227767783 0.0224943856714079 1.63385093167702 1 11.2 11 2 decreased capillary density 0.0029932227767783 0.0224943856714079 1.63385093167702 1 11.2 11 2 increased cardiac cell glucose uptake 0.0029932227767783 0.0224943856714079 1.63385093167702 1 11.2 11 2 absent neurocranium 0.00788560181479947 0.0483734513299968 1.63385093167702 1 11.2 11 2 abnormal tooth eruption 0.00788560181479947 0.0483734513299968 1.63385093167702 1 11.2 11 2 decreased sensitivity to skin irradiation 0.00788560181479947 0.0483734513299968 1.63385093167702 1 11.2 11 2 vascular inflammation 0.00788560181479947 0.0483734513299968 1.63385093167702 1 11.2 11 2 increased urine microalbumin level 0.00788560181479947 0.0483734513299968 1.63385093167702 1 11.2 11 2 absent vas deferens 0.00788560181479947 0.0483734513299968 1.63385093167702 1 11.2 11 2 absent uterus 0.00788560181479947 0.0483734513299968 1.63385093167702 1 11.2 11 2 abnormal response to vitamins 0.00788560181479947 0.0483734513299968 1.63385093167702 1 11.2 11 2 increased heart right ventricle weight 0.00788560181479947 0.0483734513299968 1.63385093167702 1 11.2 11 2 decreased unsaturated fatty acid level 0.00788560181479947 0.0483734513299968 1.63385093167702 1 11.2 11 2 abnormal hemoglobin content 0.00788560181479947 0.0483734513299968 1.63385093167702 1 11.2 11 2 increased placenta apoptosis 0.00788560181479947 0.0483734513299968 1.63385093167702 1 11.2 11 2 decreased DN3 thymocyte number 0.00788560181479947 0.0483734513299968 1.63385093167702 1 11.2 11 2 hemolysis 0.00788560181479947 0.0483734513299968 1.63385093167702 1 11.2 11 2 leptocytosis 0.00788560181479947 0.0483734513299968 1.63385093167702 1 11.2 11 2 increased thyroid carcinoma incidence 0.00788560181479947 0.0483734513299968 1.63385093167702 1 11.2 11 2 aorta hypoplasia 0.00788560181479947 0.0483734513299968 1.63385093167702 1 11.2 11 2 pale lung 0.00788560181479947 0.0483734513299968 1.63385093167702 1 11.2 11 2 decreased pre-pro B cell number 0.00788560181479947 0.0483734513299968 1.63385093167702 1 11.2 11 2 delayed optic fissure closure 0.00788560181479947 0.0483734513299968 1.63385093167702 1 11.2 11 2 cystinuria 0.00788560181479947 0.0483734513299968 1.63385093167702 1 11.2 11 2 impaired somite development 5.0367765394477e-06 9.86533987549303e-05 1.5317352484472 0.9375 11.2 11 2 testis degeneration 3.07725017499129e-05 0.000495447236912028 1.51714729370009 0.928571428571429 11.2 11 2 absent ovary 0.000184448807625487 0.00231725459074948 1.4976966873706 0.916666666666667 11.2 11 2 hematuria 0.000184448807625487 0.00231725459074948 1.4976966873706 0.916666666666667 11.2 11 2 embryonic lethality before implantation, incomplete penetrance 3.6206787019202e-07 9.84310193554809e-06 1.48531902879729 0.909090909090909 11.2 11 2 abnormal eye distance/ position 0.000447493733842988 0.00493632223030791 1.48531902879729 0.909090909090909 11.2 11 2 common atrioventricular valve 0.000447493733842988 0.00493632223030791 1.48531902879729 0.909090909090909 11.2 11 2 ketoaciduria 0.00107756716056085 0.0100579673992312 1.47046583850932 0.9 11.2 11 2 absent seminal vesicle 0.00107756716056085 0.0100579673992312 1.47046583850932 0.9 11.2 11 2 thin ventricle myocardium compact layer 0.00107756716056085 0.0100579673992312 1.47046583850932 0.9 11.2 11 2 decreased circulating lactate level 0.00107756716056085 0.0100579673992312 1.47046583850932 0.9 11.2 11 2 increased fatty acid oxidation 0.00107756716056085 0.0100579673992312 1.47046583850932 0.9 11.2 11 2 embryonic lethality between implantation and somite formation, incomplete penetrance 4.95673300614985e-06 9.7856137720617e-05 1.46186662307944 0.894736842105263 11.2 11 2 decreased circulating bicarbonate level 0.0025716224102764 0.0198046772308438 1.45231193926846 0.888888888888889 11.2 11 2 liver hyperplasia 0.0025716224102764 0.0198046772308438 1.45231193926846 0.888888888888889 11.2 11 2 positive geotaxis 0.0025716224102764 0.0198046772308438 1.45231193926846 0.888888888888889 11.2 11 2 enhanced conditioned place preference behavior 0.0025716224102764 0.0198046772308438 1.45231193926846 0.888888888888889 11.2 11 2 decreased transitional stage T1 B cell number 0.0025716224102764 0.0198046772308438 1.45231193926846 0.888888888888889 11.2 11 2 iris coloboma 0.0025716224102764 0.0198046772308438 1.45231193926846 0.888888888888889 11.2 11 2 abnormal pulmonary alveolar system morphology 0.0025716224102764 0.0198046772308438 1.45231193926846 0.888888888888889 11.2 11 2 increased cardiac muscle glycogen level 0.0025716224102764 0.0198046772308438 1.45231193926846 0.888888888888889 11.2 11 2 aminoaciduria 2.76173408504998e-05 0.000454954538845155 1.44163317500913 0.882352941176471 11.2 11 2 failure of vascular branching 0.00607047936628962 0.0401604186799081 1.42961956521739 0.875 11.2 11 2 clubfoot 0.00607047936628962 0.0401604186799081 1.42961956521739 0.875 11.2 11 2 increased sensitivity to skin irradiation 0.00607047936628962 0.0401604186799081 1.42961956521739 0.875 11.2 11 2 short ureter 0.00607047936628962 0.0401604186799081 1.42961956521739 0.875 11.2 11 2 abnormal neuron apoptosis 0.00607047936628962 0.0401604186799081 1.42961956521739 0.875 11.2 11 2 elevated level of mitotic sister chromatid exchange 0.00607047936628962 0.0401604186799081 1.42961956521739 0.875 11.2 11 2 binucleate 0.00607047936628962 0.0401604186799081 1.42961956521739 0.875 11.2 11 2 abnormal somite size 0.00607047936628962 0.0401604186799081 1.42961956521739 0.875 11.2 11 2 craniofacial phenotype 0.00607047936628962 0.0401604186799081 1.42961956521739 0.875 11.2 11 2 stomach epithelial hyperplasia 0.00607047936628962 0.0401604186799081 1.42961956521739 0.875 11.2 11 2 abnormal mitotic spindle assembly checkpoint 0.00607047936628962 0.0401604186799081 1.42961956521739 0.875 11.2 11 2 abnormal sphingomyelin level 0.00607047936628962 0.0401604186799081 1.42961956521739 0.875 11.2 11 2 abnormal cerebellum deep nucleus morphology 0.00607047936628962 0.0401604186799081 1.42961956521739 0.875 11.2 11 2 pleural effusion 0.00607047936628962 0.0401604186799081 1.42961956521739 0.875 11.2 11 2 abnormal anterior commissure pars posterior morphology 0.00607047936628962 0.0401604186799081 1.42961956521739 0.875 11.2 11 2 increased circulating ferritin level 0.00607047936628962 0.0401604186799081 1.42961956521739 0.875 11.2 11 2 abnormal heart echocardiography feature 0.00607047936628962 0.0401604186799081 1.42961956521739 0.875 11.2 11 2 increased brain apoptosis 0.00607047936628962 0.0401604186799081 1.42961956521739 0.875 11.2 11 2 decreased hepatocyte number 0.000149702454471459 0.00197551647478915 1.41600414078675 0.866666666666667 11.2 11 2 vagina atresia 0.000149702454471459 0.00197551647478915 1.41600414078675 0.866666666666667 11.2 11 2 decreased brown adipose tissue mass 0.000149702454471459 0.00197551647478915 1.41600414078675 0.866666666666667 11.2 11 2 increased hemangioma incidence 0.000344178990465149 0.00392727173753237 1.40044365572316 0.857142857142857 11.2 11 2 multiple persisting craniopharyngeal ducts 0.000344178990465149 0.00392727173753237 1.40044365572316 0.857142857142857 11.2 11 2 abnormal vitelline vein topology 0.000344178990465149 0.00392727173753237 1.40044365572316 0.857142857142857 11.2 11 2 asymmetric rib joints 0.0141358691794888 0.0756193001805988 1.40044365572316 0.857142857142857 11.2 11 2 abnormal lacrimal gland morphology 0.0141358691794888 0.0756193001805988 1.40044365572316 0.857142857142857 11.2 11 2 abnormal gastrulation movements 0.0141358691794888 0.0756193001805988 1.40044365572316 0.857142857142857 11.2 11 2 detached tectorial membrane 0.0141358691794888 0.0756193001805988 1.40044365572316 0.857142857142857 11.2 11 2 abnormal renal/urinary system physiology 0.0141358691794888 0.0756193001805988 1.40044365572316 0.857142857142857 11.2 11 2 decreased tidal volume 0.0141358691794888 0.0756193001805988 1.40044365572316 0.857142857142857 11.2 11 2 uremia 0.0141358691794888 0.0756193001805988 1.40044365572316 0.857142857142857 11.2 11 2 abnormal spinal cord central canal morphology 0.0141358691794888 0.0756193001805988 1.40044365572316 0.857142857142857 11.2 11 2 abnormal sperm annulus morphology 0.0141358691794888 0.0756193001805988 1.40044365572316 0.857142857142857 11.2 11 2 decreased skeletal muscle glycogen level 0.0141358691794888 0.0756193001805988 1.40044365572316 0.857142857142857 11.2 11 2 coronary fistula 0.0141358691794888 0.0756193001805988 1.40044365572316 0.857142857142857 11.2 11 2 increased compact bone volume 0.0141358691794888 0.0756193001805988 1.40044365572316 0.857142857142857 11.2 11 2 embryonic lethality at implantation, incomplete penetrance 0.0141358691794888 0.0756193001805988 1.40044365572316 0.857142857142857 11.2 11 2 small tail bud 0.0141358691794888 0.0756193001805988 1.40044365572316 0.857142857142857 11.2 11 2 abnormal Mullerian duct morphology 1.36634851988437e-06 3.22091437677887e-05 1.38248924988055 0.846153846153846 11.2 11 2 absent common myeloid progenitor cells 0.000783420534522029 0.00770260308151599 1.38248924988055 0.846153846153846 11.2 11 2 increased foot pad pigmentation 0.000783420534522029 0.00770260308151599 1.38248924988055 0.846153846153846 11.2 11 2 abnormal tail bud morphology 0.000783420534522029 0.00770260308151599 1.38248924988055 0.846153846153846 11.2 11 2 abnormal coping response 0.000783420534522029 0.00770260308151599 1.38248924988055 0.846153846153846 11.2 11 2 pale kidney 2.01082092174048e-07 5.71647662037651e-06 1.37032658785814 0.838709677419355 11.2 11 2 decreased cellular sensitivity to gamma-irradiation 0.000107024582049109 0.00144686765134325 1.36154244306418 0.833333333333333 11.2 11 2 delayed somite formation 0.0017627183649305 0.0149906390863747 1.36154244306418 0.833333333333333 11.2 11 2 decreased red blood cell distribution width 0.0017627183649305 0.0149906390863747 1.36154244306418 0.833333333333333 11.2 11 2 embryonic lethality between implantation and placentation, incomplete penetrance 0.0017627183649305 0.0149906390863747 1.36154244306418 0.833333333333333 11.2 11 2 thin tail 0.0323474970049053 0.142596500048028 1.36154244306418 0.833333333333333 11.2 11 2 abnormal lens induction 0.0323474970049053 0.142596500048028 1.36154244306418 0.833333333333333 11.2 11 2 abnormal lacrimal gland physiology 0.0323474970049053 0.142596500048028 1.36154244306418 0.833333333333333 11.2 11 2 abnormal lymph node cortex morphology 0.0323474970049053 0.142596500048028 1.36154244306418 0.833333333333333 11.2 11 2 chromatolysis 0.0323474970049053 0.142596500048028 1.36154244306418 0.833333333333333 11.2 11 2 abnormal hippocampal fimbria morphology 0.0323474970049053 0.142596500048028 1.36154244306418 0.833333333333333 11.2 11 2 loss of hippocampal neurons 0.0323474970049053 0.142596500048028 1.36154244306418 0.833333333333333 11.2 11 2 pancreas fibrosis 0.0323474970049053 0.142596500048028 1.36154244306418 0.833333333333333 11.2 11 2 enlarged pancreas 0.0323474970049053 0.142596500048028 1.36154244306418 0.833333333333333 11.2 11 2 abnormal milk ejection 0.0323474970049053 0.142596500048028 1.36154244306418 0.833333333333333 11.2 11 2 shortened QT interval 0.0323474970049053 0.142596500048028 1.36154244306418 0.833333333333333 11.2 11 2 abnormal cholesterol level 0.0323474970049053 0.142596500048028 1.36154244306418 0.833333333333333 11.2 11 2 abnormal blastocoele morphology 0.0323474970049053 0.142596500048028 1.36154244306418 0.833333333333333 11.2 11 2 increased triiodothyronine level 0.0323474970049053 0.142596500048028 1.36154244306418 0.833333333333333 11.2 11 2 delayed chorioallantoic fusion 0.0323474970049053 0.142596500048028 1.36154244306418 0.833333333333333 11.2 11 2 absent sperm mitochondrial sheath 0.0323474970049053 0.142596500048028 1.36154244306418 0.833333333333333 11.2 11 2 abnormal neural crest cell morphology 0.0323474970049053 0.142596500048028 1.36154244306418 0.833333333333333 11.2 11 2 increased erythrocyte clearance 0.0323474970049053 0.142596500048028 1.36154244306418 0.833333333333333 11.2 11 2 enlarged lymphatic vessel 0.0323474970049053 0.142596500048028 1.36154244306418 0.833333333333333 11.2 11 2 kidney microaneurysm 0.0323474970049053 0.142596500048028 1.36154244306418 0.833333333333333 11.2 11 2 abnormal intestinal enteroendocrine cell morphology 0.0323474970049053 0.142596500048028 1.36154244306418 0.833333333333333 11.2 11 2 absent alveolar lamellar bodies 0.0323474970049053 0.142596500048028 1.36154244306418 0.833333333333333 11.2 11 2 ectopic ureteric bud 0.0323474970049053 0.142596500048028 1.36154244306418 0.833333333333333 11.2 11 2 abnormal kidney collecting duct epithelium morphology 0.0323474970049053 0.142596500048028 1.36154244306418 0.833333333333333 11.2 11 2 increased bone trabecular spacing 0.0323474970049053 0.142596500048028 1.36154244306418 0.833333333333333 11.2 11 2 decreased hippocampus volume 0.0323474970049053 0.142596500048028 1.36154244306418 0.833333333333333 11.2 11 2 abnormal cell nucleus morphology 3.01375657021125e-10 1.51448878149505e-08 1.35574864543412 0.829787234042553 11.2 11 2 decreased triglyceride level 6.57075191341509e-08 2.08213317001529e-06 1.35376220053239 0.828571428571429 11.2 11 2 decreased bone mineralization 6.57075191341509e-08 2.08213317001529e-06 1.35376220053239 0.828571428571429 11.2 11 2 increased triglyceride level 2.16387636883221e-06 4.76340041369038e-05 1.34209183673469 0.821428571428571 11.2 11 2 abnormal amino acid level 3.15199129402776e-09 1.32891158371085e-07 1.33678712591756 0.818181818181818 11.2 11 2 abnormal thrombopoiesis 0.00391289758079123 0.028090426355608 1.33678712591756 0.818181818181818 11.2 11 2 delayed hepatic development 0.00391289758079123 0.028090426355608 1.33678712591756 0.818181818181818 11.2 11 2 abnormal proximal-distal axis patterning 0.00391289758079123 0.028090426355608 1.33678712591756 0.818181818181818 11.2 11 2 loss of cortex neurons 0.00391289758079123 0.028090426355608 1.33678712591756 0.818181818181818 11.2 11 2 abnormal radial glial cell morphology 0.00391289758079123 0.028090426355608 1.33678712591756 0.818181818181818 11.2 11 2 palatal shelf hypoplasia 0.00391289758079123 0.028090426355608 1.33678712591756 0.818181818181818 11.2 11 2 abnormal palatal shelf elevation 0.00391289758079123 0.028090426355608 1.33678712591756 0.818181818181818 11.2 11 2 abnormal heart valve morphology 4.7136036169812e-06 9.38007119779259e-05 1.33128594432942 0.814814814814815 11.2 11 2 decreased bone ossification 4.7136036169812e-06 9.38007119779259e-05 1.33128594432942 0.814814814814815 11.2 11 2 kidney failure 6.8297674879721e-09 2.59374757653902e-07 1.3298786653185 0.813953488372093 11.2 11 2 increased fibroblast apoptosis 6.82449243192124e-07 1.75009535303135e-05 1.32750388198758 0.8125 11.2 11 2 disorganized yolk sac vascular plexus 0.000518708332728972 0.00547892559517332 1.32750388198758 0.8125 11.2 11 2 decreased creatinine clearance 0.000518708332728972 0.00547892559517332 1.32750388198758 0.8125 11.2 11 2 kidney degeneration 0.000518708332728972 0.00547892559517332 1.32750388198758 0.8125 11.2 11 2 liver degeneration 7.17949378539483e-05 0.00103530381398085 1.32264123040521 0.80952380952381 11.2 11 2 increased muscle cell glucose uptake 7.17949378539483e-05 0.00103530381398085 1.32264123040521 0.80952380952381 11.2 11 2 abnormal erythropoiesis 1.3755395285465e-18 2.85137881438284e-16 1.30708074534161 0.8 11.2 11 2 abnormal pericardium morphology 0.000154470209993989 0.00202234024926341 1.30708074534161 0.8 11.2 11 2 increased skin tumor incidence 0.000154470209993989 0.00202234024926341 1.30708074534161 0.8 11.2 11 2 increased cranium width 0.00854784340913862 0.0514836815501993 1.30708074534161 0.8 11.2 11 2 jaundice 0.00854784340913862 0.0514836815501993 1.30708074534161 0.8 11.2 11 2 decreased incidence of induced tumors 0.00854784340913862 0.0514836815501993 1.30708074534161 0.8 11.2 11 2 abnormal neuron specification 0.00854784340913862 0.0514836815501993 1.30708074534161 0.8 11.2 11 2 acrania 0.00854784340913862 0.0514836815501993 1.30708074534161 0.8 11.2 11 2 abnormal pillar cell morphology 0.00854784340913862 0.0514836815501993 1.30708074534161 0.8 11.2 11 2 abnormal spinal cord dorsal column morphology 0.00854784340913862 0.0514836815501993 1.30708074534161 0.8 11.2 11 2 decreased transitional stage T2 B cell number 0.00854784340913862 0.0514836815501993 1.30708074534161 0.8 11.2 11 2 abnormal cerebellar granule cell migration 0.00854784340913862 0.0514836815501993 1.30708074534161 0.8 11.2 11 2 acanthocytosis 0.00854784340913862 0.0514836815501993 1.30708074534161 0.8 11.2 11 2 fusion of atlas and odontoid process 0.00854784340913862 0.0514836815501993 1.30708074534161 0.8 11.2 11 2 ruffled hair 2.18498058962436e-05 0.00037226980936237 1.30708074534161 0.8 11.2 11 2 delayed intramembranous bone ossification 0.0011220851344399 0.0103363201791581 1.30708074534161 0.8 11.2 11 2 abnormal placenta size 0.0011220851344399 0.0103363201791581 1.30708074534161 0.8 11.2 11 2 immune system phenotype 0.0011220851344399 0.0103363201791581 1.30708074534161 0.8 11.2 11 2 kidney cysts 2.40341744452803e-13 1.95833853857816e-11 1.30266493201276 0.797297297297297 11.2 11 2 abnormal brown adipose tissue morphology 9.72244827837375e-07 2.39451387054007e-05 1.29746985750822 0.794117647058823 11.2 11 2 increased circulating bilirubin level 9.90149330463201e-10 4.56110455468002e-08 1.29474979491386 0.792452830188679 11.2 11 2 kyphoscoliosis 0.000328773975350286 0.00378622807261035 1.28988231448186 0.789473684210526 11.2 11 2 abnormal digestive system development 0.000328773975350286 0.00378622807261035 1.28988231448186 0.789473684210526 11.2 11 2 decreased liver regeneration 0.000328773975350286 0.00378622807261035 1.28988231448186 0.789473684210526 11.2 11 2 increased respiratory quotient 1.39049848749844e-08 5.16248505619755e-07 1.2862230738734 0.787234042553192 11.2 11 2 abnormal blood flow velocity 0.00239397286273059 0.0191707330200832 1.28374001774623 0.785714285714286 11.2 11 2 megacephaly 0.00239397286273059 0.0191707330200832 1.28374001774623 0.785714285714286 11.2 11 2 irregularly shaped pupil 0.00239397286273059 0.0191707330200832 1.28374001774623 0.785714285714286 11.2 11 2 amyloid beta deposits 0.00239397286273059 0.0191707330200832 1.28374001774623 0.785714285714286 11.2 11 2 failure of zygotic cell division 0.00239397286273059 0.0191707330200832 1.28374001774623 0.785714285714286 11.2 11 2 lysosomal protein accumulation 0.00239397286273059 0.0191707330200832 1.28374001774623 0.785714285714286 11.2 11 2 abnormal renal tubule epithelial cell primary cilium morphology 0.00239397286273059 0.0191707330200832 1.28374001774623 0.785714285714286 11.2 11 2 failure to gastrulate 2.9015179400084e-08 1.00243414941263e-06 1.27866594652984 0.782608695652174 11.2 11 2 abnormal sacral vertebrae morphology 9.77362896330416e-05 0.0013465439836022 1.27866594652984 0.782608695652174 11.2 11 2 abnormal Wolffian duct morphology 9.77362896330416e-05 0.0013465439836022 1.27866594652984 0.782608695652174 11.2 11 2 increased embryonic tissue cell apoptosis 4.65579971729801e-13 3.61915681149338e-11 1.27775521579869 0.782051282051282 11.2 11 2 increased fatty acid level 4.28376132787051e-06 8.6632978073804e-05 1.27644604037267 0.78125 11.2 11 2 abnormal cell differentiation 1.9458186219367e-07 5.56347565754889e-06 1.27520072716255 0.780487804878049 11.2 11 2 abnormal liver physiology 3.41726449481651e-16 5.15178510960974e-14 1.27440372670807 0.78 11.2 11 2 abnormal apoptosis 2.81273216552345e-09 1.19601218149395e-07 1.2707729468599 0.777777777777778 11.2 11 2 increased brain weight 2.93580588580725e-05 0.000480448496114837 1.2707729468599 0.777777777777778 11.2 11 2 abnormal trophoblast giant cell morphology 1.3111185075934e-06 3.1511181523078e-05 1.2707729468599 0.777777777777778 11.2 11 2 delayed kidney development 0.000691404725782181 0.00700557741500276 1.2707729468599 0.777777777777778 11.2 11 2 abnormal thymus cortex morphology 0.000691404725782181 0.00700557741500276 1.2707729468599 0.777777777777778 11.2 11 2 abnormal bile duct morphology 0.000691404725782181 0.00700557741500276 1.2707729468599 0.777777777777778 11.2 11 2 abnormal redox activity 0.000691404725782181 0.00700557741500276 1.2707729468599 0.777777777777778 11.2 11 2 long tibia 0.000691404725782181 0.00700557741500276 1.2707729468599 0.777777777777778 11.2 11 2 abnormal anterior eye segment morphology 0.000691404725782181 0.00700557741500276 1.2707729468599 0.777777777777778 11.2 11 2 abnormal glycogen homeostasis 0.000691404725782181 0.00700557741500276 1.2707729468599 0.777777777777778 11.2 11 2 decreased lactate dehydrogenase level 0.000691404725782181 0.00700557741500276 1.2707729468599 0.777777777777778 11.2 11 2 small thoracic cage 0.000691404725782181 0.00700557741500276 1.2707729468599 0.777777777777778 11.2 11 2 abnormal aerobic respiration 0.000691404725782181 0.00700557741500276 1.2707729468599 0.777777777777778 11.2 11 2 abnormal metanephric mesenchyme morphology 0.000691404725782181 0.00700557741500276 1.2707729468599 0.777777777777778 11.2 11 2 distorted hair follicle pattern 0.0183164787123359 0.093942764529764 1.2707729468599 0.777777777777778 11.2 11 2 renal tubular acidosis 0.0183164787123359 0.093942764529764 1.2707729468599 0.777777777777778 11.2 11 2 synostosis 0.0183164787123359 0.093942764529764 1.2707729468599 0.777777777777778 11.2 11 2 abnormal geniculate ganglion morphology 0.0183164787123359 0.093942764529764 1.2707729468599 0.777777777777778 11.2 11 2 biliary cyst 0.0183164787123359 0.093942764529764 1.2707729468599 0.777777777777778 11.2 11 2 premature neuronal precursor differentiation 0.0183164787123359 0.093942764529764 1.2707729468599 0.777777777777778 11.2 11 2 decreased fear-related response 0.0183164787123359 0.093942764529764 1.2707729468599 0.777777777777778 11.2 11 2 short frontal bone 0.0183164787123359 0.093942764529764 1.2707729468599 0.777777777777778 11.2 11 2 abnormal posterior eye segment morphology 0.0183164787123359 0.093942764529764 1.2707729468599 0.777777777777778 11.2 11 2 abnormal inguinal fat pad morphology 0.0183164787123359 0.093942764529764 1.2707729468599 0.777777777777778 11.2 11 2 decreased susceptibility to atherosclerosis 0.0183164787123359 0.093942764529764 1.2707729468599 0.777777777777778 11.2 11 2 eye opacity 0.0183164787123359 0.093942764529764 1.2707729468599 0.777777777777778 11.2 11 2 decreased effector memory CD4-positive, alpha-beta T cell number 0.0183164787123359 0.093942764529764 1.2707729468599 0.777777777777778 11.2 11 2 abnormal oxidative phosphorylation 0.0183164787123359 0.093942764529764 1.2707729468599 0.777777777777778 11.2 11 2 abnormal lung lobe morphology 0.0183164787123359 0.093942764529764 1.2707729468599 0.777777777777778 11.2 11 2 abnormal infrahyoid muscle connection 0.0183164787123359 0.093942764529764 1.2707729468599 0.777777777777778 11.2 11 2 renal interstitial fibrosis 1.24179884078183e-07 3.67735073386286e-06 1.2625211744777 0.772727272727273 11.2 11 2 abnormal lysosome physiology 0.00020354863939658 0.00251279027542924 1.2625211744777 0.772727272727273 11.2 11 2 abnormal vascular branching morphogenesis 0.00020354863939658 0.00251279027542924 1.2625211744777 0.772727272727273 11.2 11 2 prolonged PR interval 0.00020354863939658 0.00251279027542924 1.2625211744777 0.772727272727273 11.2 11 2 abnormal blood-brain barrier function 0.00020354863939658 0.00251279027542924 1.2625211744777 0.772727272727273 11.2 11 2 abnormal placenta morphology 1.28428531756694e-12 9.25988326796452e-11 1.26158109914301 0.772151898734177 11.2 11 2 abnormal circulating amino acid level 1.80400925904756e-09 7.87275970505403e-08 1.26121826304893 0.771929824561403 11.2 11 2 decreased glycogen level 2.7069725296092e-06 5.80482255810594e-05 1.26039929015084 0.771428571428571 11.2 11 2 vertebral transformation 3.83826833633066e-08 1.29900578049286e-06 1.25942675983437 0.770833333333333 11.2 11 2 increased hepatocyte apoptosis 8.28470540404598e-07 2.09220352208775e-05 1.25680840898232 0.769230769230769 11.2 11 2 increased thymocyte apoptosis 6.07153281300142e-05 0.000885839279482417 1.25680840898232 0.769230769230769 11.2 11 2 tight skin 0.00502704446629208 0.034591350234859 1.25680840898232 0.769230769230769 11.2 11 2 orthokeratosis 0.00502704446629208 0.034591350234859 1.25680840898232 0.769230769230769 11.2 11 2 abnormal embryonic-extraembryonic boundary morphology 0.00143462819640908 0.0124674399737622 1.24941541834125 0.764705882352941 11.2 11 2 increased brain size 0.00143462819640908 0.0124674399737622 1.24941541834125 0.764705882352941 11.2 11 2 enhanced behavioral response to cocaine 0.00143462819640908 0.0124674399737622 1.24941541834125 0.764705882352941 11.2 11 2 increased circulating magnesium level 0.00143462819640908 0.0124674399737622 1.24941541834125 0.764705882352941 11.2 11 2 abnormal cell cytoskeleton morphology 0.00143462819640908 0.0124674399737622 1.24941541834125 0.764705882352941 11.2 11 2 decreased hair follicle number 1.69174254701067e-06 3.79117980692707e-05 1.24688623733246 0.763157894736842 11.2 11 2 impaired branching involved in ureteric bud morphogenesis 1.69174254701067e-06 3.79117980692707e-05 1.24688623733246 0.763157894736842 11.2 11 2 abnormal erythrocyte physiology 0.000419031080842119 0.00470582308620664 1.24483880508725 0.761904761904762 11.2 11 2 embryonic lethality between implantation and placentation, complete penetrance 1.59440984448864e-07 4.63870700370234e-06 1.24314744801512 0.760869565217391 11.2 11 2 spontaneous skin ulceration 0.000124291477477193 0.00166671186104861 1.24172670807453 0.76 11.2 11 2 increased mortality induced by gamma-irradiation 3.72729245209662e-05 0.000581294042294066 1.23947312058257 0.758620689655172 11.2 11 2 blood in lymph vessels 3.72729245209662e-05 0.000581294042294066 1.23947312058257 0.758620689655172 11.2 11 2 decreased brown adipose tissue amount 1.12692595949191e-05 0.000204615206148623 1.23776585733107 0.757575757575758 11.2 11 2 atrioventricular septal defect 3.0637712304679e-08 1.05119047390192e-06 1.23309504277511 0.754716981132076 11.2 11 2 decreased mean corpuscular hemoglobin 5.69033714590109e-10 2.77543404910372e-08 1.22538819875776 0.75 11.2 11 2 abnormal urine homeostasis 1.65596645080555e-13 1.42041949875132e-11 1.22538819875776 0.75 11.2 11 2 abnormal retinal blood vessel morphology 6.89453459565656e-06 0.000130917212264853 1.22538819875776 0.75 11.2 11 2 failure of primitive streak formation 2.26994821793647e-05 0.000382813301160473 1.22538819875776 0.75 11.2 11 2 abnormal spongiotrophoblast layer morphology 2.26994821793647e-05 0.000382813301160473 1.22538819875776 0.75 11.2 11 2 pancreatic islet hyperplasia 2.26994821793647e-05 0.000382813301160473 1.22538819875776 0.75 11.2 11 2 premature aging 7.5244424851707e-05 0.00108191044403827 1.22538819875776 0.75 11.2 11 2 dilated vasculature 0.000851685271419176 0.00816403511620501 1.22538819875776 0.75 11.2 11 2 abnormal neuron proliferation 0.000851685271419176 0.00816403511620501 1.22538819875776 0.75 11.2 11 2 absent ductus venosus valve 0.000851685271419176 0.00816403511620501 1.22538819875776 0.75 11.2 11 2 abnormal bone marrow cell number 0.0029322155395727 0.0222036108209653 1.22538819875776 0.75 11.2 11 2 intraventricular hemorrhage 0.0029322155395727 0.0222036108209653 1.22538819875776 0.75 11.2 11 2 increased thymus weight 0.0029322155395727 0.0222036108209653 1.22538819875776 0.75 11.2 11 2 blepharitis 0.0029322155395727 0.0222036108209653 1.22538819875776 0.75 11.2 11 2 dystonia 0.0029322155395727 0.0222036108209653 1.22538819875776 0.75 11.2 11 2 decreased circulating triiodothyronine level 0.0029322155395727 0.0222036108209653 1.22538819875776 0.75 11.2 11 2 decreased liver cholesterol level 0.0029322155395727 0.0222036108209653 1.22538819875776 0.75 11.2 11 2 impaired embryo implantation 0.0103634352283734 0.0608714170733858 1.22538819875776 0.75 11.2 11 2 abnormal thymus involution 0.0103634352283734 0.0608714170733858 1.22538819875776 0.75 11.2 11 2 abnormal embryonic growth/weight/body size 0.0103634352283734 0.0608714170733858 1.22538819875776 0.75 11.2 11 2 abnormal respiratory function 0.0103634352283734 0.0608714170733858 1.22538819875776 0.75 11.2 11 2 abnormal corticospinal tract morphology 0.0103634352283734 0.0608714170733858 1.22538819875776 0.75 11.2 11 2 increased urine phosphate level 0.0103634352283734 0.0608714170733858 1.22538819875776 0.75 11.2 11 2 dilated bile duct 0.0103634352283734 0.0608714170733858 1.22538819875776 0.75 11.2 11 2 abnormal rostral-caudal body axis extension 0.0103634352283734 0.0608714170733858 1.22538819875776 0.75 11.2 11 2 increased hepatocyte proliferation 0.0103634352283734 0.0608714170733858 1.22538819875776 0.75 11.2 11 2 pale placenta 0.0103634352283734 0.0608714170733858 1.22538819875776 0.75 11.2 11 2 abnormal fatty acid level 0.0103634352283734 0.0608714170733858 1.22538819875776 0.75 11.2 11 2 hemoperitoneum 0.0103634352283734 0.0608714170733858 1.22538819875776 0.75 11.2 11 2 increased skeletal muscle glycogen level 0.0103634352283734 0.0608714170733858 1.22538819875776 0.75 11.2 11 2 abnormal pulmonary valve cusp morphology 0.0103634352283734 0.0608714170733858 1.22538819875776 0.75 11.2 11 2 prenatal growth retardation 0.0103634352283734 0.0608714170733858 1.22538819875776 0.75 11.2 11 2 abnormal colon goblet cell morphology 0.0103634352283734 0.0608714170733858 1.22538819875776 0.75 11.2 11 2 abnormal urination 0.0383320386190864 0.160523478223868 1.22538819875776 0.75 11.2 11 2 abnormal secondary sex determination 0.0383320386190864 0.160523478223868 1.22538819875776 0.75 11.2 11 2 coarse hair 0.0383320386190864 0.160523478223868 1.22538819875776 0.75 11.2 11 2 early eyelid opening 0.0383320386190864 0.160523478223868 1.22538819875776 0.75 11.2 11 2 colon polyps 0.0383320386190864 0.160523478223868 1.22538819875776 0.75 11.2 11 2 liver failure 0.0383320386190864 0.160523478223868 1.22538819875776 0.75 11.2 11 2 liver cysts 0.0383320386190864 0.160523478223868 1.22538819875776 0.75 11.2 11 2 increased left ventricle systolic pressure 0.0383320386190864 0.160523478223868 1.22538819875776 0.75 11.2 11 2 abnormal forelimb zeugopod morphology 0.0383320386190864 0.160523478223868 1.22538819875776 0.75 11.2 11 2 abnormal skin development 0.0383320386190864 0.160523478223868 1.22538819875776 0.75 11.2 11 2 tau protein deposits 0.0383320386190864 0.160523478223868 1.22538819875776 0.75 11.2 11 2 absent interparietal bone 0.0383320386190864 0.160523478223868 1.22538819875776 0.75 11.2 11 2 accumulation of giant lysosomes in kidney/renal tubule cells 0.0383320386190864 0.160523478223868 1.22538819875776 0.75 11.2 11 2 Sertoli cell hypoplasia 0.0383320386190864 0.160523478223868 1.22538819875776 0.75 11.2 11 2 abnormal epidermal lamellar body morphology 0.0383320386190864 0.160523478223868 1.22538819875776 0.75 11.2 11 2 abnormal brain ependyma morphology 0.0383320386190864 0.160523478223868 1.22538819875776 0.75 11.2 11 2 heart right ventricle hypoplasia 0.0383320386190864 0.160523478223868 1.22538819875776 0.75 11.2 11 2 anomalous pulmonary venous connection 0.0383320386190864 0.160523478223868 1.22538819875776 0.75 11.2 11 2 increased heart right ventricle size 0.0383320386190864 0.160523478223868 1.22538819875776 0.75 11.2 11 2 lung situs inversus 0.0383320386190864 0.160523478223868 1.22538819875776 0.75 11.2 11 2 abnormal bronchiole epithelium morphology 0.0383320386190864 0.160523478223868 1.22538819875776 0.75 11.2 11 2 abnormal maxillary prominence morphology 0.0383320386190864 0.160523478223868 1.22538819875776 0.75 11.2 11 2 abnormal foramen magnum morphology 0.0383320386190864 0.160523478223868 1.22538819875776 0.75 11.2 11 2 absent ureteric bud 0.0383320386190864 0.160523478223868 1.22538819875776 0.75 11.2 11 2 increased aorta wall thickness 0.0383320386190864 0.160523478223868 1.22538819875776 0.75 11.2 11 2 impaired neuron differentiation 0.0383320386190864 0.160523478223868 1.22538819875776 0.75 11.2 11 2 increased cornea thickness 0.0383320386190864 0.160523478223868 1.22538819875776 0.75 11.2 11 2 increased circulating lactate level 0.0383320386190864 0.160523478223868 1.22538819875776 0.75 11.2 11 2 increased testis apoptosis 0.0383320386190864 0.160523478223868 1.22538819875776 0.75 11.2 11 2 embryo cyst 0.0383320386190864 0.160523478223868 1.22538819875776 0.75 11.2 11 2 increased mammary gland apoptosis 0.0383320386190864 0.160523478223868 1.22538819875776 0.75 11.2 11 2 decreased basal metabolism 0.0383320386190864 0.160523478223868 1.22538819875776 0.75 11.2 11 2 absent mesoderm 5.88647756405021e-09 2.27017254892634e-07 1.22538819875776 0.75 11.2 11 2 abnormal hepatocyte morphology 3.18424981073694e-15 3.77181971628959e-13 1.22170835431705 0.747747747747748 11.2 11 2 abnormal blood homeostasis 1.98112153286167e-15 2.52719990409918e-13 1.21822218589953 0.745614035087719 11.2 11 2 abnormal head morphology 3.77667308483725e-08 1.28691428747023e-06 1.21796160361378 0.745454545454545 11.2 11 2 pale liver 2.17644289519592e-10 1.15189397910635e-08 1.21434866543562 0.743243243243243 11.2 11 2 abnormal postnatal growth/weight/body size 4.52976643271461e-05 0.000693402707777082 1.21221198156682 0.741935483870968 11.2 11 2 abnormal nose morphology 4.52976643271461e-05 0.000693402707777082 1.21221198156682 0.741935483870968 11.2 11 2 abnormal mitochondrial ATP synthesis coupled electron transport 4.52976643271461e-05 0.000693402707777082 1.21221198156682 0.741935483870968 11.2 11 2 abnormal enzyme/coenzyme level 2.31642259741726e-08 8.29079310946106e-07 1.21130327693296 0.741379310344828 11.2 11 2 decreased circulating alkaline phosphatase level 2.4143729510446e-07 6.74803675923982e-06 1.20904968944099 0.74 11.2 11 2 dilated heart 0.000503350297059939 0.0053507857433188 1.20762894950041 0.739130434782609 11.2 11 2 abnormal hepatocyte physiology 0.000503350297059939 0.0053507857433188 1.20762894950041 0.739130434782609 11.2 11 2 abnormal hematopoietic stem cell physiology 0.000503350297059939 0.0053507857433188 1.20762894950041 0.739130434782609 11.2 11 2 decreased embryo size 6.45555784309016e-58 1.07054667564578e-54 1.20658865874893 0.738493723849372 11.2 11 2 abnormal pancreas morphology 2.54238481041043e-06 5.49928888338777e-05 1.20593759242828 0.738095238095238 11.2 11 2 increased hepatocellular carcinoma incidence 4.55673823847494e-08 1.50130945274257e-06 1.20389016018307 0.736842105263158 11.2 11 2 persistence of hyaloid vascular system 8.29252235762182e-06 0.000154514227450069 1.20389016018307 0.736842105263158 11.2 11 2 delayed sexual maturation 0.00170677082699148 0.0146147760142558 1.20389016018307 0.736842105263158 11.2 11 2 oliguria 0.00170677082699148 0.0146147760142558 1.20389016018307 0.736842105263158 11.2 11 2 abnormal blastocyst morphology 0.00170677082699148 0.0146147760142558 1.20389016018307 0.736842105263158 11.2 11 2 increased liver cholesterol level 0.00170677082699148 0.0146147760142558 1.20389016018307 0.736842105263158 11.2 11 2 increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 0.00170677082699148 0.0146147760142558 1.20389016018307 0.736842105263158 11.2 11 2 enlarged kidney 1.46871712050733e-07 4.323590339955e-06 1.20226766670573 0.735849056603774 11.2 11 2 abnormal direction of heart looping 2.71674464980494e-05 0.000449030054245169 1.20136097917428 0.735294117647059 11.2 11 2 abnormal neural tube closure 5.04014133929333e-11 2.91566315848655e-09 1.20078201002769 0.734939759036145 11.2 11 2 abnormal ectoderm development 1.53596526470968e-06 3.52139501932289e-05 1.19815734989648 0.733333333333333 11.2 11 2 abnormal myocardial trabeculae morphology 1.53596526470968e-06 3.52139501932289e-05 1.19815734989648 0.733333333333333 11.2 11 2 macrocytosis 0.00589166411552997 0.040097166860139 1.19815734989648 0.733333333333333 11.2 11 2 abnormal cricoid cartilage morphology 0.00589166411552997 0.040097166860139 1.19815734989648 0.733333333333333 11.2 11 2 abnormal trophectoderm morphology 0.00589166411552997 0.040097166860139 1.19815734989648 0.733333333333333 11.2 11 2 decreased thymocyte apoptosis 0.00589166411552997 0.040097166860139 1.19815734989648 0.733333333333333 11.2 11 2 abnormal branching involved in lung morphogenesis 0.00589166411552997 0.040097166860139 1.19815734989648 0.733333333333333 11.2 11 2 thick ventricular wall 4.98760610697444e-06 9.80764441984104e-05 1.19550068171489 0.731707317073171 11.2 11 2 decreased bone resorption 0.000296855311419533 0.00347495335132277 1.19396798853321 0.730769230769231 11.2 11 2 embryonic lethality between implantation and somite formation, complete penetrance 4.88488290525686e-29 2.20929931396844e-26 1.19371149702117 0.730612244897959 11.2 11 2 decreased susceptibility to hepatic steatosis 1.68266796522601e-08 6.11041834087548e-07 1.19297052154195 0.73015873015873 11.2 11 2 abnormal chromosome morphology 1.62520453668293e-05 0.000288764020357056 1.19226959879134 0.72972972972973 11.2 11 2 oligodactyly 9.25723368948328e-07 2.30273688025897e-05 1.19134963768116 0.729166666666667 11.2 11 2 small heart 9.25723368948328e-07 2.30273688025897e-05 1.19134963768116 0.729166666666667 11.2 11 2 single kidney 5.31800757378865e-05 0.000804166798771993 1.18825522303783 0.727272727272727 11.2 11 2 abnormal facial nerve morphology 0.000993650924696891 0.00938029098741372 1.18825522303783 0.727272727272727 11.2 11 2 abnormal germ layer development 0.000993650924696891 0.00938029098741372 1.18825522303783 0.727272727272727 11.2 11 2 aphakia 0.000993650924696891 0.00938029098741372 1.18825522303783 0.727272727272727 11.2 11 2 abnormal circulating lipid level 0.000993650924696891 0.00938029098741372 1.18825522303783 0.727272727272727 11.2 11 2 abnormal sphenoid bone morphology 0.0209076989513983 0.100877204196338 1.18825522303783 0.727272727272727 11.2 11 2 decreased atrioventricular cushion size 0.0209076989513983 0.100877204196338 1.18825522303783 0.727272727272727 11.2 11 2 abnormal large intestine morphology 0.0209076989513983 0.100877204196338 1.18825522303783 0.727272727272727 11.2 11 2 abnormal food preference 0.0209076989513983 0.100877204196338 1.18825522303783 0.727272727272727 11.2 11 2 impaired myelopoiesis 0.0209076989513983 0.100877204196338 1.18825522303783 0.727272727272727 11.2 11 2 pharyngeal arch hypoplasia 0.0209076989513983 0.100877204196338 1.18825522303783 0.727272727272727 11.2 11 2 abnormal dorsal-ventral polarity of the somites 0.0209076989513983 0.100877204196338 1.18825522303783 0.727272727272727 11.2 11 2 increased glycogen level 0.0209076989513983 0.100877204196338 1.18825522303783 0.727272727272727 11.2 11 2 abnormal palate development 0.0209076989513983 0.100877204196338 1.18825522303783 0.727272727272727 11.2 11 2 increased number of Howell-Jolly bodies 0.0209076989513983 0.100877204196338 1.18825522303783 0.727272727272727 11.2 11 2 aorta dilation 0.0209076989513983 0.100877204196338 1.18825522303783 0.727272727272727 11.2 11 2 abnormal pulmonary alveolar sac morphology 0.0209076989513983 0.100877204196338 1.18825522303783 0.727272727272727 11.2 11 2 abnormal brain ependyma motile cilium morphology 0.0209076989513983 0.100877204196338 1.18825522303783 0.727272727272727 11.2 11 2 hypolactation 0.0209076989513983 0.100877204196338 1.18825522303783 0.727272727272727 11.2 11 2 abnormal extraembryonic tissue morphology 1.33714373341156e-12 9.50327153388932e-11 1.18534283278529 0.725490196078431 11.2 11 2 abnormal gastrulation 5.56886237491779e-07 1.4429734539175e-05 1.18534283278529 0.725490196078431 11.2 11 2 abnormal gluconeogenesis 5.56886237491779e-07 1.4429734539175e-05 1.18534283278529 0.725490196078431 11.2 11 2 polychromatophilia 0.000174919613219901 0.00220869308570814 1.18313343328336 0.724137931034483 11.2 11 2 narrow eye opening 3.15644680804475e-05 0.000506558802258794 1.18000345065562 0.722222222222222 11.2 11 2 abnormal mitral valve morphology 0.00336700922003902 0.0249640400442535 1.18000345065562 0.722222222222222 11.2 11 2 cortical renal glomerulopathies 0.00336700922003902 0.0249640400442535 1.18000345065562 0.722222222222222 11.2 11 2 right pulmonary isomerism 0.00336700922003902 0.0249640400442535 1.18000345065562 0.722222222222222 11.2 11 2 abnormal body wall morphology 0.00336700922003902 0.0249640400442535 1.18000345065562 0.722222222222222 11.2 11 2 increased effector memory CD4-positive, alpha-beta T cell number 0.00336700922003902 0.0249640400442535 1.18000345065562 0.722222222222222 11.2 11 2 increased adipocyte glucose uptake 0.00336700922003902 0.0249640400442535 1.18000345065562 0.722222222222222 11.2 11 2 abnormal placenta labyrinth morphology 7.07764859018452e-10 3.34317655360234e-08 1.17885446969101 0.721518987341772 11.2 11 2 abnormal double-strand DNA break repair 5.78817395547172e-06 0.000111613044296402 1.17789253213925 0.720930232558139 11.2 11 2 delayed bone ossification 2.24747124288293e-09 9.72275602899354e-08 1.17637267080745 0.72 11.2 11 2 abnormal thyroid gland morphology 0.00057909954829133 0.00607810179904929 1.17637267080745 0.72 11.2 11 2 abnormal preimplantation embryo development 0.00057909954829133 0.00607810179904929 1.17637267080745 0.72 11.2 11 2 decreased cell proliferation 6.65768479776917e-21 1.57723723185246e-18 1.17460634547591 0.718918918918919 11.2 11 2 scoliosis 0.000103048574260365 0.00139691187178561 1.17433035714286 0.71875 11.2 11 2 small liver 1.35461853454299e-09 5.96391788438176e-08 1.17302118171683 0.717948717948718 11.2 11 2 abnormal iris morphology 1.87219903358673e-05 0.000324536243626968 1.17302118171683 0.717948717948718 11.2 11 2 abnormal allantois morphology 3.44913785612679e-06 7.20985749337428e-05 1.17211045098569 0.717391304347826 11.2 11 2 abnormal mesoderm development 6.41766793666891e-07 1.65429523237968e-05 1.17144029063635 0.716981132075472 11.2 11 2 decreased hemoglobin content 4.72225172837283e-16 6.90976539666318e-14 1.17034712127219 0.716312056737589 11.2 11 2 small kidney 1.55432816543018e-10 8.31482002474749e-09 1.16968873517787 0.715909090909091 11.2 11 2 lethality throughout fetal growth and development, complete penetrance 4.6576069188021e-21 1.21955760110739e-18 1.16949329846355 0.715789473684211 11.2 11 2 lethality throughout fetal growth and development, incomplete penetrance 7.58613143789471e-20 1.71550017743301e-17 1.16834033103161 0.715083798882682 11.2 11 2 abnormal embryonic tissue morphology 1.72687574723762e-16 2.86373561416905e-14 1.1670363797693 0.714285714285714 11.2 11 2 absent kidney 2.05407618730918e-06 4.54179068082808e-05 1.1670363797693 0.714285714285714 11.2 11 2 abnormal reproductive system morphology 1.11006593483845e-05 0.000202292235378069 1.1670363797693 0.714285714285714 11.2 11 2 ovary cysts 6.07178280007044e-05 0.000885839279482417 1.1670363797693 0.714285714285714 11.2 11 2 abnormal embryonic epiblast morphology 6.07178280007044e-05 0.000885839279482417 1.1670363797693 0.714285714285714 11.2 11 2 abnormal mitotic spindle morphology 0.0003379652790452 0.00388308836778261 1.1670363797693 0.714285714285714 11.2 11 2 abnormal eye pigmentation 0.00193332074786182 0.0162196808104765 1.1670363797693 0.714285714285714 11.2 11 2 trunk curl 0.00193332074786182 0.0162196808104765 1.1670363797693 0.714285714285714 11.2 11 2 absent segment of posterior cerebral artery 0.00193332074786182 0.0162196808104765 1.1670363797693 0.714285714285714 11.2 11 2 abnormal fluid regulation 0.0116097234751958 0.0666186554660889 1.1670363797693 0.714285714285714 11.2 11 2 increased lactate dehydrogenase level 0.0116097234751958 0.0666186554660889 1.1670363797693 0.714285714285714 11.2 11 2 abnormal ventral body wall morphology 0.0116097234751958 0.0666186554660889 1.1670363797693 0.714285714285714 11.2 11 2 absent olfactory bulb 0.0116097234751958 0.0666186554660889 1.1670363797693 0.714285714285714 11.2 11 2 vascular smooth muscle hypoplasia 0.0116097234751958 0.0666186554660889 1.1670363797693 0.714285714285714 11.2 11 2 split sternum 0.0116097234751958 0.0666186554660889 1.1670363797693 0.714285714285714 11.2 11 2 abnormal glucose tolerance 0.0116097234751958 0.0666186554660889 1.1670363797693 0.714285714285714 11.2 11 2 decreased tongue size 0.0116097234751958 0.0666186554660889 1.1670363797693 0.714285714285714 11.2 11 2 increased stomach tumor incidence 0.0116097234751958 0.0666186554660889 1.1670363797693 0.714285714285714 11.2 11 2 failure of atrioventricular cushion closure 0.0778765665684466 0.252744604400809 1.1670363797693 0.714285714285714 11.2 11 2 cellular necrosis 0.0778765665684466 0.252744604400809 1.1670363797693 0.714285714285714 11.2 11 2 mammary gland hyperplasia 0.0778765665684466 0.252744604400809 1.1670363797693 0.714285714285714 11.2 11 2 abnormal oculomotor nerve morphology 0.0778765665684466 0.252744604400809 1.1670363797693 0.714285714285714 11.2 11 2 skin photosensitivity 0.0778765665684466 0.252744604400809 1.1670363797693 0.714285714285714 11.2 11 2 absent epidermis stratum corneum 0.0778765665684466 0.252744604400809 1.1670363797693 0.714285714285714 11.2 11 2 excessive tearing 0.0778765665684466 0.252744604400809 1.1670363797693 0.714285714285714 11.2 11 2 limp posture 0.0778765665684466 0.252744604400809 1.1670363797693 0.714285714285714 11.2 11 2 abnormal circulating alanine transaminase level 0.0778765665684466 0.252744604400809 1.1670363797693 0.714285714285714 11.2 11 2 abnormal axial mesoderm 0.0778765665684466 0.252744604400809 1.1670363797693 0.714285714285714 11.2 11 2 abnormal tumor incidence 0.0778765665684466 0.252744604400809 1.1670363797693 0.714285714285714 11.2 11 2 decreased cholesterol efflux 0.0778765665684466 0.252744604400809 1.1670363797693 0.714285714285714 11.2 11 2 calcinosis 0.0778765665684466 0.252744604400809 1.1670363797693 0.714285714285714 11.2 11 2 aorta coarctation 0.0778765665684466 0.252744604400809 1.1670363797693 0.714285714285714 11.2 11 2 abnormal locus ceruleus morphology 0.0778765665684466 0.252744604400809 1.1670363797693 0.714285714285714 11.2 11 2 renal necrosis 0.0778765665684466 0.252744604400809 1.1670363797693 0.714285714285714 11.2 11 2 abnormal organ of Corti supporting cell morphology 0.0778765665684466 0.252744604400809 1.1670363797693 0.714285714285714 11.2 11 2 absent vestibular saccule 0.0778765665684466 0.252744604400809 1.1670363797693 0.714285714285714 11.2 11 2 abnormal vestibular saccular macula morphology 0.0778765665684466 0.252744604400809 1.1670363797693 0.714285714285714 11.2 11 2 urolithiasis 0.0778765665684466 0.252744604400809 1.1670363797693 0.714285714285714 11.2 11 2 absent fibula 0.0778765665684466 0.252744604400809 1.1670363797693 0.714285714285714 11.2 11 2 abnormal thyroid hormone level 0.0778765665684466 0.252744604400809 1.1670363797693 0.714285714285714 11.2 11 2 retinal pigment epithelium atrophy 0.0778765665684466 0.252744604400809 1.1670363797693 0.714285714285714 11.2 11 2 decreased brain cholesterol level 0.0778765665684466 0.252744604400809 1.1670363797693 0.714285714285714 11.2 11 2 abnormal retina inner limiting membrane morphology 0.0778765665684466 0.252744604400809 1.1670363797693 0.714285714285714 11.2 11 2 heart block 0.0778765665684466 0.252744604400809 1.1670363797693 0.714285714285714 11.2 11 2 abnormal aortic valve cusp morphology 0.0778765665684466 0.252744604400809 1.1670363797693 0.714285714285714 11.2 11 2 thick pulmonary valve 0.0778765665684466 0.252744604400809 1.1670363797693 0.714285714285714 11.2 11 2 thick mitral valve cusps 0.0778765665684466 0.252744604400809 1.1670363797693 0.714285714285714 11.2 11 2 increased circulating lactate dehydrogenase level 0.0778765665684466 0.252744604400809 1.1670363797693 0.714285714285714 11.2 11 2 impaired mammary gland growth during pregnancy 0.0778765665684466 0.252744604400809 1.1670363797693 0.714285714285714 11.2 11 2 decreased CD8-positive, naive alpha-beta T cell number 0.0778765665684466 0.252744604400809 1.1670363797693 0.714285714285714 11.2 11 2 decreased areal bone mineral density 0.0778765665684466 0.252744604400809 1.1670363797693 0.714285714285714 11.2 11 2 decreased femur compact bone thickness 0.0778765665684466 0.252744604400809 1.1670363797693 0.714285714285714 11.2 11 2 fragmented Meckel's cartilage 0.0778765665684466 0.252744604400809 1.1670363797693 0.714285714285714 11.2 11 2 embryo tumor 0.0778765665684466 0.252744604400809 1.1670363797693 0.714285714285714 11.2 11 2 short limbs 2.95150615929066e-10 1.49834113698684e-08 1.16435353751696 0.71264367816092 11.2 11 2 eyelids open at birth 1.22276260741998e-06 2.96743608386068e-05 1.16254777830865 0.711538461538462 11.2 11 2 decreased birth body size 7.4922879868647e-13 5.56330339323163e-11 1.16089408303367 0.710526315789474 11.2 11 2 microcephaly 2.57985024927687e-08 9.00082790323741e-07 1.16027095148078 0.710144927536232 11.2 11 2 decreased heart rate 2.03792739395184e-11 1.23642546157444e-09 1.16003416149068 0.71 11.2 11 2 small cranium 0.000197525972801759 0.00246907466002199 1.15950711280305 0.709677419354839 11.2 11 2 increased oxygen consumption 5.57972713717817e-10 2.7484299512338e-08 1.15889426549184 0.709302325581395 11.2 11 2 increased circulating creatinine level 5.57972713717817e-10 2.7484299512338e-08 1.15889426549184 0.709302325581395 11.2 11 2 abnormal primitive streak formation 0.001114652227893 0.0103363201791581 1.15731107660455 0.708333333333333 11.2 11 2 increased body temperature 0.001114652227893 0.0103363201791581 1.15731107660455 0.708333333333333 11.2 11 2 abnormal embryo size 1.41166794842172e-12 9.89161696253248e-11 1.15670862419612 0.707964601769911 11.2 11 2 abnormal lipid homeostasis 3.13784869538687e-14 3.18587699174483e-12 1.15626373626374 0.707692307692308 11.2 11 2 palatal shelves fail to meet at midline 2.11053076849603e-05 0.000360820981899235 1.15565065899106 0.707317073170732 11.2 11 2 decreased erythrocyte cell number 8.12819078974578e-17 1.4442053278209e-14 1.15514301538948 0.707006369426752 11.2 11 2 abnormal embryonic neuroepithelium morphology 4.32988380559218e-07 1.14580701770325e-05 1.15496358963375 0.706896551724138 11.2 11 2 preweaning lethality, complete penetrance 3.00313172243988e-74 1.49405803191384e-70 1.15473518549606 0.706756756756757 11.2 11 2 increased bone mineral content 4.41610762706266e-12 2.89080729534694e-10 1.15418827283606 0.706422018348624 11.2 11 2 abnormal lung development 1.05002349088604e-09 4.79253841023674e-08 1.15330654000731 0.705882352941177 11.2 11 2 small lung 2.31297704086907e-06 5.04695648172089e-05 1.15330654000731 0.705882352941177 11.2 11 2 increased kidney weight 2.31297704086907e-06 5.04695648172089e-05 1.15330654000731 0.705882352941177 11.2 11 2 hyperlipidemia 0.0065264251631654 0.0426101905337899 1.15330654000731 0.705882352941177 11.2 11 2 nephrocalcinosis 0.0065264251631654 0.0426101905337899 1.15330654000731 0.705882352941177 11.2 11 2 increased hepatoma incidence 0.0065264251631654 0.0426101905337899 1.15330654000731 0.705882352941177 11.2 11 2 increased trabecular bone mass 0.0065264251631654 0.0426101905337899 1.15330654000731 0.705882352941177 11.2 11 2 prenatal lethality, complete penetrance 2.57732117050575e-28 9.86320986405084e-26 1.15192367844855 0.705035971223022 11.2 11 2 polydactyly 7.19730312256647e-11 4.06892989031457e-09 1.15036443148688 0.704081632653061 11.2 11 2 abnormal maxilla morphology 1.37150545193953e-06 3.22091437677887e-05 1.14974695192087 0.703703703703704 11.2 11 2 abnormal neuronal precursor proliferation 1.37150545193953e-06 3.22091437677887e-05 1.14974695192087 0.703703703703704 11.2 11 2 abnormal osteoblast physiology 1.37150545193953e-06 3.22091437677887e-05 1.14974695192087 0.703703703703704 11.2 11 2 abnormal atrioventricular cushion morphology 0.000644906301672542 0.00668418510587687 1.14974695192087 0.703703703703704 11.2 11 2 abnormal type II pneumocyte morphology 0.000644906301672542 0.00668418510587687 1.14974695192087 0.703703703703704 11.2 11 2 increased neuron apoptosis 3.29256323789606e-09 1.37651278222966e-07 1.14974695192086 0.703703703703704 11.2 11 2 embryonic lethality during organogenesis, complete penetrance 1.16823739272407e-54 1.45299525720056e-51 1.14661324312334 0.701785714285714 11.2 11 2 enlarged liver 8.03674413149585e-11 4.49244966901032e-09 1.14369565217391 0.7 11.2 11 2 abnormal kidney development 4.82502992424769e-07 1.26339599332275e-05 1.14369565217391 0.7 11.2 11 2 abnormal brain vasculature morphology 0.000374248424787936 0.00423155889390905 1.14369565217391 0.7 11.2 11 2 increased urine glucose level 0.00370197045666021 0.026886573754576 1.14369565217391 0.7 11.2 11 2 increased mammary adenocarcinoma incidence 0.00370197045666021 0.026886573754576 1.14369565217391 0.7 11.2 11 2 abnormal trachea morphology 0.00370197045666021 0.026886573754576 1.14369565217391 0.7 11.2 11 2 decreased myocardial infarction size 0.00370197045666021 0.026886573754576 1.14369565217391 0.7 11.2 11 2 abnormal lens epithelium morphology 0.00370197045666021 0.026886573754576 1.14369565217391 0.7 11.2 11 2 abnormal physiological neovascularization 0.00370197045666021 0.026886573754576 1.14369565217391 0.7 11.2 11 2 kidney atrophy 0.00370197045666021 0.026886573754576 1.14369565217391 0.7 11.2 11 2 increased urine calcium level 0.00370197045666021 0.026886573754576 1.14369565217391 0.7 11.2 11 2 abnormal sperm mitochondrial sheath morphology 0.00370197045666021 0.026886573754576 1.14369565217391 0.7 11.2 11 2 abnormal prostate gland epithelium morphology 0.0411099610864629 0.165032564239577 1.14369565217391 0.7 11.2 11 2 fused cornea and lens 0.0411099610864629 0.165032564239577 1.14369565217391 0.7 11.2 11 2 abnormal mammary gland physiology 0.0411099610864629 0.165032564239577 1.14369565217391 0.7 11.2 11 2 abnormal primordial germ cell migration 0.0411099610864629 0.165032564239577 1.14369565217391 0.7 11.2 11 2 aneurysm 0.0411099610864629 0.165032564239577 1.14369565217391 0.7 11.2 11 2 abnormal hypaxial muscle morphology 0.0411099610864629 0.165032564239577 1.14369565217391 0.7 11.2 11 2 bifid ureter 0.0411099610864629 0.165032564239577 1.14369565217391 0.7 11.2 11 2 increased atrioventricular cushion size 0.0411099610864629 0.165032564239577 1.14369565217391 0.7 11.2 11 2 abnormal hindlimb zeugopod morphology 0.0411099610864629 0.165032564239577 1.14369565217391 0.7 11.2 11 2 increased heart rate variability 0.0411099610864629 0.165032564239577 1.14369565217391 0.7 11.2 11 2 abnormal gas homeostasis 0.0411099610864629 0.165032564239577 1.14369565217391 0.7 11.2 11 2 abnormal plasma membrane morphology 0.0411099610864629 0.165032564239577 1.14369565217391 0.7 11.2 11 2 abnormal placental transport 0.0411099610864629 0.165032564239577 1.14369565217391 0.7 11.2 11 2 osteosclerosis 0.0411099610864629 0.165032564239577 1.14369565217391 0.7 11.2 11 2 vascular smooth muscle hyperplasia 0.0411099610864629 0.165032564239577 1.14369565217391 0.7 11.2 11 2 crystalluria 0.0411099610864629 0.165032564239577 1.14369565217391 0.7 11.2 11 2 increased circulating fructosamine level 0.0411099610864629 0.165032564239577 1.14369565217391 0.7 11.2 11 2 abnormal left subclavian artery morphology 0.0411099610864629 0.165032564239577 1.14369565217391 0.7 11.2 11 2 abnormal inferior vena cava valve morphology 0.0411099610864629 0.165032564239577 1.14369565217391 0.7 11.2 11 2 thick aortic valve 0.0411099610864629 0.165032564239577 1.14369565217391 0.7 11.2 11 2 abnormal circadian temperature homeostasis 0.0411099610864629 0.165032564239577 1.14369565217391 0.7 11.2 11 2 lethality during fetal growth through weaning, complete penetrance 0.0411099610864629 0.165032564239577 1.14369565217391 0.7 11.2 11 2 pale yolk sac 3.66610509112424e-09 1.49498957609369e-07 1.14172715707551 0.698795180722892 11.2 11 2 abnormal liver morphology 4.78051930361231e-18 9.5132334141885e-16 1.14095735452306 0.698324022346369 11.2 11 2 abnormal organ of Corti morphology 2.33602410243368e-05 0.000392625672621878 1.13989599884443 0.697674418604651 11.2 11 2 enlarged pericardium 0.000217746120862067 0.00267478259577477 1.13874458874459 0.696969696969697 11.2 11 2 abnormal somite development 1.14268106128384e-08 4.2743144961557e-07 1.13749115496501 0.69620253164557 11.2 11 2 increased lymphocyte cell number 1.00850145067783e-07 3.09709550439644e-06 1.13659195247097 0.695652173913043 11.2 11 2 abnormal cell death 1.37389712233229e-05 0.000245868279985724 1.13659195247097 0.695652173913043 11.2 11 2 abnormal forelimb morphology 1.37389712233229e-05 0.000245868279985724 1.13659195247097 0.695652173913043 11.2 11 2 abnormal pulmonary artery morphology 0.00211433807358136 0.0176787091026341 1.13659195247097 0.695652173913043 11.2 11 2 hydrops fetalis 5.98779491852586e-08 1.92188901417201e-06 1.13461870255349 0.694444444444444 11.2 11 2 cataract 2.18576538088698e-12 1.48961407807024e-10 1.13424362199066 0.694214876033058 11.2 11 2 increased circulating LDL cholesterol level 8.08829554864768e-06 0.000151846303224612 1.13369248320446 0.693877551020408 11.2 11 2 increased urine protein level 2.1121974695056e-08 7.61462493535535e-07 1.13112756808409 0.692307692307692 11.2 11 2 increased insulin sensitivity 3.22356752690209e-14 3.20744968926758e-12 1.13112756808409 0.692307692307692 11.2 11 2 liver hypoplasia 4.76595951612951e-06 9.44647354292602e-05 1.13112756808409 0.692307692307692 11.2 11 2 heart inflammation 0.00121414908125287 0.0109625983289165 1.13112756808409 0.692307692307692 11.2 11 2 decreased circulating glycerol level 0.00121414908125287 0.0109625983289165 1.13112756808409 0.692307692307692 11.2 11 2 absent myocardial trabeculae 0.0223703144430564 0.105827423614097 1.13112756808409 0.692307692307692 11.2 11 2 absent trabeculae carneae 0.0223703144430564 0.105827423614097 1.13112756808409 0.692307692307692 11.2 11 2 pup cannibalization 0.0223703144430564 0.105827423614097 1.13112756808409 0.692307692307692 11.2 11 2 abnormal grip strength 0.0223703144430564 0.105827423614097 1.13112756808409 0.692307692307692 11.2 11 2 increased pituitary adenoma incidence 0.0223703144430564 0.105827423614097 1.13112756808409 0.692307692307692 11.2 11 2 anal atresia 0.0223703144430564 0.105827423614097 1.13112756808409 0.692307692307692 11.2 11 2 abnormal vertebral arch development 0.0223703144430564 0.105827423614097 1.13112756808409 0.692307692307692 11.2 11 2 increased circulating ammonia level 0.0223703144430564 0.105827423614097 1.13112756808409 0.692307692307692 11.2 11 2 increased circulating thyroxine level 0.0223703144430564 0.105827423614097 1.13112756808409 0.692307692307692 11.2 11 2 absent hypoglossal nerve 0.0223703144430564 0.105827423614097 1.13112756808409 0.692307692307692 11.2 11 2 double outlet right ventricle 5.84672317639802e-11 3.34338480489427e-09 1.12995298078598 0.691588785046729 11.2 11 2 disheveled coat 4.34233693588603e-05 0.000672994587415359 1.12813516711032 0.69047619047619 11.2 11 2 perinatal lethality, incomplete penetrance 2.37958222883652e-21 6.57690088247872e-19 1.12779090859122 0.690265486725664 11.2 11 2 embryonic lethality, complete penetrance 2.00256617345568e-29 9.96276671294201e-27 1.12679374598415 0.689655172413793 11.2 11 2 abnormal spinal nerve morphology 0.000700288980879196 0.00708117414608536 1.12679374598415 0.689655172413793 11.2 11 2 oxidative stress 2.63465048802146e-09 1.12994708430231e-07 1.12554175293306 0.688888888888889 11.2 11 2 abnormal autopod morphology 2.54547302957395e-05 0.000423536064285298 1.12554175293306 0.688888888888889 11.2 11 2 small placenta 2.54547302957395e-05 0.000423536064285298 1.12554175293306 0.688888888888889 11.2 11 2 extramedullary hematopoiesis 1.0728355018273e-10 5.86522705669321e-09 1.12519922653229 0.688679245283019 11.2 11 2 embryonic lethality before implantation, complete penetrance 2.62496631664975e-12 1.741227656711e-10 1.12408944099379 0.688 11.2 11 2 overriding aortic valve 1.49419282784137e-05 0.000266437609982467 1.12327251552795 0.6875 11.2 11 2 kidney cortex cysts 0.00040537624959283 0.00456277566000979 1.12327251552795 0.6875 11.2 11 2 abnormal tympanic ring morphology 0.012402450982636 0.0698779089905028 1.12327251552795 0.6875 11.2 11 2 vasculature congestion 0.012402450982636 0.0698779089905028 1.12327251552795 0.6875 11.2 11 2 abnormal hair follicle orientation 0.012402450982636 0.0698779089905028 1.12327251552795 0.6875 11.2 11 2 delayed hair appearance 0.012402450982636 0.0698779089905028 1.12327251552795 0.6875 11.2 11 2 poor circulation 0.012402450982636 0.0698779089905028 1.12327251552795 0.6875 11.2 11 2 increased heart left ventricle size 0.012402450982636 0.0698779089905028 1.12327251552795 0.6875 11.2 11 2 embryonic lethality between somite formation and embryo turning, incomplete penetrance 0.012402450982636 0.0698779089905028 1.12327251552795 0.6875 11.2 11 2 decreased fibroblast apoptosis 0.012402450982636 0.0698779089905028 1.12327251552795 0.6875 11.2 11 2 decreased white adipose tissue amount 3.42328789757907e-07 9.35761389585487e-06 1.12174840085288 0.686567164179104 11.2 11 2 embryonic lethality between somite formation and embryo turning, complete penetrance 2.0253367875962e-07 5.72502870357449e-06 1.12035492457853 0.685714285714286 11.2 11 2 abnormal liver development 0.000235375966814131 0.00287008685024584 1.12035492457853 0.685714285714286 11.2 11 2 increased red blood cell distribution width 0.000235375966814131 0.00287008685024584 1.12035492457853 0.685714285714286 11.2 11 2 embryonic growth arrest 5.1822784421517e-21 1.28909176248523e-18 1.12015107542922 0.685589519650655 11.2 11 2 decreased rib number 4.81805291436403e-09 1.93304945556138e-07 1.11983041384605 0.685393258426966 11.2 11 2 increased circulating alkaline phosphatase level 2.91409783805586e-15 3.5714371840449e-13 1.11949045318611 0.685185185185185 11.2 11 2 abnormal cell adhesion 5.16678419537255e-06 0.000100802946556778 1.11949045318611 0.685185185185185 11.2 11 2 decreased hematocrit 7.02999850781476e-14 6.35895319570517e-12 1.1190759806007 0.684931506849315 11.2 11 2 decreased percent body fat/body weight 1.19886310373037e-07 3.61475390367187e-06 1.1190759806007 0.684931506849315 11.2 11 2 abnormal cell morphology 4.13102482034277e-11 2.41786452720062e-09 1.11789800588428 0.684210526315789 11.2 11 2 decreased neuron apoptosis 0.000137022357358371 0.00182757701838578 1.11789800588428 0.684210526315789 11.2 11 2 abnormal triglyceride level 0.00696419240497533 0.0448212900578943 1.11789800588428 0.684210526315789 11.2 11 2 decreased germ cell number 0.00696419240497533 0.0448212900578943 1.11789800588428 0.684210526315789 11.2 11 2 increased liver adenoma incidence 0.00696419240497533 0.0448212900578943 1.11789800588428 0.684210526315789 11.2 11 2 increased circulating VLDL cholesterol level 0.00696419240497533 0.0448212900578943 1.11789800588428 0.684210526315789 11.2 11 2 decreased susceptibility to weight gain 0.00696419240497533 0.0448212900578943 1.11789800588428 0.684210526315789 11.2 11 2 abnormal developmental patterning 2.49310671091587e-08 8.83832669956379e-07 1.11580063626723 0.682926829268293 11.2 11 2 Leydig cell hyperplasia 7.99446232542691e-05 0.00112989914968747 1.11580063626723 0.682926829268293 11.2 11 2 liver fibrosis 7.99446232542691e-05 0.00112989914968747 1.11580063626723 0.682926829268293 11.2 11 2 increased bone trabecula number 7.99446232542691e-05 0.00112989914968747 1.11580063626723 0.682926829268293 11.2 11 2 abnormal astrocyte morphology 4.67335270965119e-05 0.000713188028543394 1.11398927159797 0.681818181818182 11.2 11 2 abnormal enterocyte morphology 0.00394689894035806 0.0281719113748656 1.11398927159797 0.681818181818182 11.2 11 2 abnormal tail movements 0.00394689894035806 0.0281719113748656 1.11398927159797 0.681818181818182 11.2 11 2 intestinal inflammation 0.00394689894035806 0.0281719113748656 1.11398927159797 0.681818181818182 11.2 11 2 intracerebral hemorrhage 0.00394689894035806 0.0281719113748656 1.11398927159797 0.681818181818182 11.2 11 2 abnormal forebrain development 2.18197880829612e-07 6.13296303461761e-06 1.11192632850242 0.680555555555556 11.2 11 2 abnormal cornea morphology 7.63794667678523e-08 2.37492404481291e-06 1.11018076126772 0.67948717948718 11.2 11 2 failure of blastocyst to hatch from the zona pellucida 0.00129289290499693 0.0115271365633687 1.10868456078083 0.678571428571429 11.2 11 2 abnormal hormone level 0.00129289290499693 0.0115271365633687 1.10868456078083 0.678571428571429 11.2 11 2 hypoxia 0.00129289290499693 0.0115271365633687 1.10868456078083 0.678571428571429 11.2 11 2 subcutaneous edema 0.00129289290499693 0.0115271365633687 1.10868456078083 0.678571428571429 11.2 11 2 decreased circulating cholesterol level 2.75458195449504e-16 4.28251413237901e-14 1.10709024878661 0.677595628415301 11.2 11 2 decreased circulating glucose level 5.0272195875281e-24 1.78645838913945e-21 1.10680224403927 0.67741935483871 11.2 11 2 hypoglycemia 5.58083998941044e-09 2.17701176510777e-07 1.10680224403927 0.67741935483871 11.2 11 2 lethargy 5.58083998941044e-09 2.17701176510777e-07 1.10680224403927 0.67741935483871 11.2 11 2 prenatal lethality 1.92105793521811e-06 4.26663536951344e-05 1.10680224403927 0.67741935483871 11.2 11 2 abnormal eyelid morphology 0.000745365573958903 0.00746115438721437 1.10680224403927 0.67741935483871 11.2 11 2 decreased thymus weight 0.000745365573958903 0.00746115438721437 1.10680224403927 0.67741935483871 11.2 11 2 abnormal brain morphology 1.86232694128533e-14 1.93022427768636e-12 1.10614752517264 0.677018633540373 11.2 11 2 decreased liver weight 3.94703362862051e-07 1.05625983667231e-05 1.10457527775348 0.676056338028169 11.2 11 2 malocclusion 0.000250346291185979 0.00302299222973361 1.1039533322142 0.675675675675676 11.2 11 2 increased erythroid progenitor cell number 0.000250346291185979 0.00302299222973361 1.1039533322142 0.675675675675676 11.2 11 2 atrial septal defect 4.9667299045401e-05 0.000755641629207554 1.10107345395625 0.673913043478261 11.2 11 2 decreased circulating creatinine level 2.90775457835564e-05 0.000477428350736611 1.10034858663962 0.673469387755102 11.2 11 2 microphthalmia 1.69103874365138e-13 1.42591826265519e-11 1.09991271871067 0.673202614379085 11.2 11 2 distended pericardium 1.70491935759304e-05 0.000299716388834819 1.09970735785953 0.673076923076923 11.2 11 2 abnormal placenta vasculature 1.70491935759304e-05 0.000299716388834819 1.09970735785953 0.673076923076923 11.2 11 2 kinked neural tube 1.70491935759304e-05 0.000299716388834819 1.09970735785953 0.673076923076923 11.2 11 2 abnormal neural tube morphology 3.56633825786344e-14 3.47892800644522e-12 1.0993194540296 0.672839506172839 11.2 11 2 abnormal embryo turning 1.00100133183462e-05 0.000184885842035488 1.09913608130999 0.672727272727273 11.2 11 2 glomerulosclerosis 5.88419820992536e-06 0.000113026587236983 1.09862390233455 0.672413793103448 11.2 11 2 decreased circulating HDL cholesterol level 1.92774528175295e-11 1.18401639218777e-09 1.0977435947205 0.671875 11.2 11 2 abnormal axial skeleton morphology 2.47514646223432e-07 6.87924784894734e-06 1.09639996730958 0.671052631578947 11.2 11 2 abnormal renal glomerulus morphology 7.82209015729898e-10 3.63690640491238e-08 1.09423044048094 0.669724770642202 11.2 11 2 abnormal cell cycle 2.7579272401297e-10 1.41450391955106e-08 1.09396975425331 0.669565217391304 11.2 11 2 pallor 8.46689153520159e-15 9.36061897502842e-13 1.09234605146406 0.668571428571429 11.2 11 2 increased rib number 2.60943380356936e-07 7.17233876947931e-06 1.08923395445135 0.666666666666667 11.2 11 2 increased circulating alanine transaminase level 2.60943380356936e-07 7.17233876947931e-06 1.08923395445135 0.666666666666667 11.2 11 2 perimembraneous ventricular septal defect 1.26700211242055e-06 3.05987160645255e-05 1.08923395445135 0.666666666666667 11.2 11 2 gliosis 3.64673290952627e-06 7.59100260455781e-05 1.08923395445135 0.666666666666667 11.2 11 2 increased cell proliferation 1.79385196668082e-05 0.000312042431267031 1.08923395445135 0.666666666666667 11.2 11 2 distended abdomen 3.05819674566657e-05 0.000493978208106856 1.08923395445135 0.666666666666667 11.2 11 2 abnormal trophoblast layer morphology 3.05819674566657e-05 0.000493978208106856 1.08923395445135 0.666666666666667 11.2 11 2 abnormal kidney physiology 5.22129571236976e-05 0.000791949578324377 1.08923395445135 0.666666666666667 11.2 11 2 abnormal lysosome morphology 0.000452176972076181 0.00496596122754746 1.08923395445135 0.666666666666667 11.2 11 2 belly spot 0.000780636507054358 0.00770260308151599 1.08923395445135 0.666666666666667 11.2 11 2 increased cardiomyocyte apoptosis 0.000780636507054358 0.00770260308151599 1.08923395445135 0.666666666666667 11.2 11 2 abnormal trigeminal ganglion morphology 0.00235263464041354 0.0190935682480544 1.08923395445135 0.666666666666667 11.2 11 2 thin epidermis 0.00235263464041354 0.0190935682480544 1.08923395445135 0.666666666666667 11.2 11 2 abnormal eye muscle morphology 0.00235263464041354 0.0190935682480544 1.08923395445135 0.666666666666667 11.2 11 2 abnormal body weight 0.00411370976495806 0.0291534274653367 1.08923395445135 0.666666666666667 11.2 11 2 blindness 0.00411370976495806 0.0291534274653367 1.08923395445135 0.666666666666667 11.2 11 2 abnormal impulse conducting system conduction 0.00411370976495806 0.0291534274653367 1.08923395445135 0.666666666666667 11.2 11 2 decreased fatty acid level 0.00411370976495806 0.0291534274653367 1.08923395445135 0.666666666666667 11.2 11 2 abnormal heart shape 0.0128452570494182 0.0709269187800836 1.08923395445135 0.666666666666667 11.2 11 2 abnormal phrenic nerve morphology 0.0128452570494182 0.0709269187800836 1.08923395445135 0.666666666666667 11.2 11 2 absent allantois 0.0128452570494182 0.0709269187800836 1.08923395445135 0.666666666666667 11.2 11 2 absent ureter 0.0128452570494182 0.0709269187800836 1.08923395445135 0.666666666666667 11.2 11 2 abnormal eye anterior chamber morphology 0.0128452570494182 0.0709269187800836 1.08923395445135 0.666666666666667 11.2 11 2 abnormal pregnancy 0.0128452570494182 0.0709269187800836 1.08923395445135 0.666666666666667 11.2 11 2 increased effector memory CD8-positive, alpha-beta T cell number 0.0128452570494182 0.0709269187800836 1.08923395445135 0.666666666666667 11.2 11 2 abnormal hypoglossal nerve topology 0.0128452570494182 0.0709269187800836 1.08923395445135 0.666666666666667 11.2 11 2 abnormal mineral level 0.0419962263974481 0.165032564239577 1.08923395445135 0.666666666666667 11.2 11 2 amyloidosis 0.0419962263974481 0.165032564239577 1.08923395445135 0.666666666666667 11.2 11 2 mesocardia 0.0419962263974481 0.165032564239577 1.08923395445135 0.666666666666667 11.2 11 2 abnormal glossopharyngeal nerve morphology 0.0419962263974481 0.165032564239577 1.08923395445135 0.666666666666667 11.2 11 2 abnormal mating frequency 0.0419962263974481 0.165032564239577 1.08923395445135 0.666666666666667 11.2 11 2 myocarditis 0.0419962263974481 0.165032564239577 1.08923395445135 0.666666666666667 11.2 11 2 decreased circulating ketone body level 0.0419962263974481 0.165032564239577 1.08923395445135 0.666666666666667 11.2 11 2 abnormal vascular endothelial cell development 0.0419962263974481 0.165032564239577 1.08923395445135 0.666666666666667 11.2 11 2 increased osteosarcoma incidence 0.0419962263974481 0.165032564239577 1.08923395445135 0.666666666666667 11.2 11 2 abnormal nucleotide metabolism 0.0419962263974481 0.165032564239577 1.08923395445135 0.666666666666667 11.2 11 2 abnormal amacrine cell morphology 0.0419962263974481 0.165032564239577 1.08923395445135 0.666666666666667 11.2 11 2 decreased renal glomerular filtration rate 0.0419962263974481 0.165032564239577 1.08923395445135 0.666666666666667 11.2 11 2 abnormal thymus corticomedullary boundary morphology 0.0419962263974481 0.165032564239577 1.08923395445135 0.666666666666667 11.2 11 2 reduced cerebellar foliation 0.0419962263974481 0.165032564239577 1.08923395445135 0.666666666666667 11.2 11 2 increased type II pneumocyte number 0.0419962263974481 0.165032564239577 1.08923395445135 0.666666666666667 11.2 11 2 heart hyperplasia 0.0783631584325874 0.252744604400809 1.08923395445135 0.666666666666667 11.2 11 2 abnormal head movements 0.0783631584325874 0.252744604400809 1.08923395445135 0.666666666666667 11.2 11 2 thick tail 0.0783631584325874 0.252744604400809 1.08923395445135 0.666666666666667 11.2 11 2 dilated uterus 0.0783631584325874 0.252744604400809 1.08923395445135 0.666666666666667 11.2 11 2 abnormal lens vesicle development 0.0783631584325874 0.252744604400809 1.08923395445135 0.666666666666667 11.2 11 2 abnormal ion homeostasis 0.0783631584325874 0.252744604400809 1.08923395445135 0.666666666666667 11.2 11 2 abnormal lung volume 0.0783631584325874 0.252744604400809 1.08923395445135 0.666666666666667 11.2 11 2 increased pheochromocytoma incidence 0.0783631584325874 0.252744604400809 1.08923395445135 0.666666666666667 11.2 11 2 abnormal germ cell morphology 0.0783631584325874 0.252744604400809 1.08923395445135 0.666666666666667 11.2 11 2 abnormal thymus physiology 0.0783631584325874 0.252744604400809 1.08923395445135 0.666666666666667 11.2 11 2 absent adrenal gland 0.0783631584325874 0.252744604400809 1.08923395445135 0.666666666666667 11.2 11 2 abnormal liver vasculature morphology 0.0783631584325874 0.252744604400809 1.08923395445135 0.666666666666667 11.2 11 2 abnormal cerebellar layer morphology 0.0783631584325874 0.252744604400809 1.08923395445135 0.666666666666667 11.2 11 2 prolonged RR interval 0.0783631584325874 0.252744604400809 1.08923395445135 0.666666666666667 11.2 11 2 fusion of atlas and occipital bones 0.0783631584325874 0.252744604400809 1.08923395445135 0.666666666666667 11.2 11 2 symmetric azygos veins 0.0783631584325874 0.252744604400809 1.08923395445135 0.666666666666667 11.2 11 2 decreased fatty acid oxidation 0.0783631584325874 0.252744604400809 1.08923395445135 0.666666666666667 11.2 11 2 albuminuria 8.92911206980569e-05 0.00124432304054015 1.08923395445135 0.666666666666667 11.2 11 2 abnormal scapula morphology 0.00723926987425702 0.0462328210839906 1.08923395445135 0.666666666666667 11.2 11 2 left pulmonary isomerism 0.00723926987425702 0.0462328210839906 1.08923395445135 0.666666666666667 11.2 11 2 abnormal embryonic/fetal subventricular zone morphology 0.00723926987425702 0.0462328210839906 1.08923395445135 0.666666666666667 11.2 11 2 complete atrioventricular septal defect 0.00723926987425702 0.0462328210839906 1.08923395445135 0.666666666666667 11.2 11 2 vascular ring 0.00723926987425702 0.0462328210839906 1.08923395445135 0.666666666666667 11.2 11 2 abnormal apical ectodermal ridge morphology 0.0230458421945274 0.106755968333675 1.08923395445135 0.666666666666667 11.2 11 2 absent egg cylinders 0.0230458421945274 0.106755968333675 1.08923395445135 0.666666666666667 11.2 11 2 abnormal lymph node B cell domain morphology 0.0230458421945274 0.106755968333675 1.08923395445135 0.666666666666667 11.2 11 2 abnormal energy homeostasis 0.0230458421945274 0.106755968333675 1.08923395445135 0.666666666666667 11.2 11 2 abnormal coronary vessel morphology 0.0230458421945274 0.106755968333675 1.08923395445135 0.666666666666667 11.2 11 2 heterochrony 0.0230458421945274 0.106755968333675 1.08923395445135 0.666666666666667 11.2 11 2 prenatal lethality, incomplete penetrance 5.77241644941463e-24 1.91451812238919e-21 1.08565094802223 0.664473684210526 11.2 11 2 abnormal bone structure 1.24343791621015e-15 1.67191990085013e-13 1.08359025520548 0.663212435233161 11.2 11 2 short tail 1.61739117032773e-07 4.67820992580258e-06 1.08267230412333 0.662650602409639 11.2 11 2 abnormal enzyme/coenzyme activity 6.27425479963611e-13 4.72945721639237e-11 1.08229615856312 0.662420382165605 11.2 11 2 abnormal angiogenesis 7.8286047267109e-07 1.98710757731565e-05 1.08187426556992 0.662162162162162 11.2 11 2 ventricular septal defect 2.37873865387329e-11 1.42581021723128e-09 1.08122488125685 0.661764705882353 11.2 11 2 pericardial effusion 6.47240975233957e-06 0.000123372561371224 1.08044980965738 0.661290322580645 11.2 11 2 abnormal interventricular septum morphology 5.43693964108776e-05 0.000817183526115154 1.07834161490683 0.66 11.2 11 2 testicular atrophy 5.43693964108776e-05 0.000817183526115154 1.07834161490683 0.66 11.2 11 2 increased cellular sensitivity to gamma-irradiation 9.28768321105264e-05 0.00128708144777122 1.07764635919123 0.659574468085106 11.2 11 2 abnormal glucose homeostasis 1.81868641551419e-14 1.92509891854959e-12 1.07726435055628 0.659340659340659 11.2 11 2 small spleen 5.91463608112949e-08 1.92188901417201e-06 1.07726435055628 0.659340659340659 11.2 11 2 increased grip strength 5.91463608112949e-08 1.92188901417201e-06 1.07726435055628 0.659340659340659 11.2 11 2 abnormal nervous system morphology 4.81677977215467e-07 1.26339599332275e-05 1.07544618287601 0.658227848101266 11.2 11 2 decreased total retina thickness 0.000468276933162149 0.00513144877198611 1.07490192873488 0.657894736842105 11.2 11 2 decreased bone marrow cell number 1.37900454724402e-06 3.22091437677887e-05 1.07431294137667 0.657534246575342 11.2 11 2 seminiferous tubule degeneration 1.37900454724402e-06 3.22091437677887e-05 1.07431294137667 0.657534246575342 11.2 11 2 abnormal midbrain development 0.000806828814859991 0.0078635771882911 1.07367346938775 0.657142857142857 11.2 11 2 decreased circulating thyroxine level 0.000806828814859991 0.0078635771882911 1.07367346938775 0.657142857142857 11.2 11 2 polydipsia 0.00139443610229414 0.0123220596961161 1.07221467391304 0.65625 11.2 11 2 bradykinesia 0.00139443610229414 0.0123220596961161 1.07221467391304 0.65625 11.2 11 2 hemorrhage 9.03037532109487e-18 1.72792758547873e-15 1.07069380203515 0.65531914893617 11.2 11 2 preweaning lethality, incomplete penetrance 7.78678246160818e-30 4.30436030516675e-27 1.07059180853164 0.655256723716381 11.2 11 2 lordosis 0.00241884036082061 0.0192539692721321 1.07045405868494 0.655172413793103 11.2 11 2 decreased trophoblast giant cell number 0.00241884036082061 0.0192539692721321 1.07045405868494 0.655172413793103 11.2 11 2 decreased bone strength 0.00241884036082061 0.0192539692721321 1.07045405868494 0.655172413793103 11.2 11 2 increased blood urea nitrogen level 1.59962559769038e-11 9.94767168563703e-10 1.07045405868494 0.655172413793103 11.2 11 2 increased circulating calcium level 3.29609527481045e-05 0.00052390012754575 1.06942970073405 0.654545454545455 11.2 11 2 abnormal contextual conditioning behavior 3.29609527481045e-05 0.00052390012754575 1.06942970073405 0.654545454545455 11.2 11 2 azoospermia 2.08489976198085e-12 1.44060782164649e-10 1.06868237040509 0.654088050314465 11.2 11 2 decreased body temperature 5.61438736758321e-05 0.00084131256487128 1.06828714763497 0.653846153846154 11.2 11 2 abnormal ureter morphology 0.00421441212132347 0.0296062900972343 1.06828714763497 0.653846153846154 11.2 11 2 thick skin 0.00421441212132347 0.0296062900972343 1.06828714763497 0.653846153846154 11.2 11 2 abnormal digit morphology 2.41298640190348e-06 5.242186615489e-05 1.06654158040028 0.652777777777778 11.2 11 2 perinatal lethality, complete penetrance 5.86689962907726e-16 8.10772934851649e-14 1.06622196949815 0.652582159624413 11.2 11 2 decreased spleen weight 4.08558857750865e-06 8.39909222029155e-05 1.06555495544153 0.652173913043478 11.2 11 2 abnormal nasal cavity morphology 0.00738295056556441 0.0467900370237999 1.06555495544153 0.652173913043478 11.2 11 2 anophthalmia 1.80618663567888e-07 5.19409162572395e-06 1.06475678693559 0.651685393258427 11.2 11 2 abnormal left-right axis patterning 0.000279928723299216 0.00333168755601339 1.0639029322548 0.651162790697674 11.2 11 2 delayed endochondral bone ossification 0.000279928723299216 0.00333168755601339 1.0639029322548 0.651162790697674 11.2 11 2 decreased oxygen consumption 0.000279928723299216 0.00333168755601339 1.0639029322548 0.651162790697674 11.2 11 2 abnormal retinal pigment epithelium morphology 8.68414932190763e-07 2.18200216547932e-05 1.06200310559006 0.65 11.2 11 2 decreased circulating phosphate level 0.000479958613383457 0.00521352423926354 1.06200310559006 0.65 11.2 11 2 small gonad 0.0130226045947034 0.0710388792309752 1.06200310559006 0.65 11.2 11 2 absent placental labyrinth 0.0130226045947034 0.0710388792309752 1.06200310559006 0.65 11.2 11 2 abnormal postnatal subventricular zone morphology 0.0130226045947034 0.0710388792309752 1.06200310559006 0.65 11.2 11 2 decreased bone mineral content 2.94329496574555e-15 3.5714371840449e-13 1.06043209507883 0.649038461538462 11.2 11 2 increased circulating phosphate level 0.000824787459873478 0.00799866981066384 1.05979519892563 0.648648648648649 11.2 11 2 abnormal respiratory electron transport chain 0.000824787459873478 0.00799866981066384 1.05979519892563 0.648648648648649 11.2 11 2 short snout 1.40969952328511e-08 5.1950037987729e-07 1.05897745571659 0.648148148148148 11.2 11 2 abnormal chondrocyte morphology 5.75500267484353e-05 0.000857219709800795 1.05897745571659 0.648148148148148 11.2 11 2 abnormal small intestine morphology 5.75500267484353e-05 0.000857219709800795 1.05897745571659 0.648148148148148 11.2 11 2 abnormal ovary morphology 4.19331667258729e-06 8.58508248811596e-05 1.05855130784708 0.647887323943662 11.2 11 2 embryonic lethality during organogenesis, incomplete penetrance 1.4074166311244e-16 2.41444749649789e-14 1.05845125573859 0.647826086956522 11.2 11 2 enlarged liver sinusoidal spaces 0.00142108189777071 0.0124674399737622 1.05719766167337 0.647058823529412 11.2 11 2 abnormal adipose tissue morphology 0.0231751649849987 0.106755968333675 1.05719766167337 0.647058823529412 11.2 11 2 abnormal vagus nerve morphology 0.0231751649849987 0.106755968333675 1.05719766167337 0.647058823529412 11.2 11 2 increased incidence of corneal inflammation 0.0231751649849987 0.106755968333675 1.05719766167337 0.647058823529412 11.2 11 2 abnormal dorsal-ventral axis patterning 0.0231751649849987 0.106755968333675 1.05719766167337 0.647058823529412 11.2 11 2 abnormal testis development 0.0231751649849987 0.106755968333675 1.05719766167337 0.647058823529412 11.2 11 2 abnormal ectoplacental cone morphology 0.0231751649849987 0.106755968333675 1.05719766167337 0.647058823529412 11.2 11 2 abnormal ductus venosus valve morphology 0.0231751649849987 0.106755968333675 1.05719766167337 0.647058823529412 11.2 11 2 impaired balance 3.98855426254993e-08 1.34074712541797e-06 1.05719766167336 0.647058823529412 11.2 11 2 failure of chorioallantoic fusion 9.79796828269341e-05 0.0013465439836022 1.05719766167336 0.647058823529412 11.2 11 2 osteopetrosis 0.00245601467324865 0.0193082348535427 1.0540973752755 0.645161290322581 11.2 11 2 abnormal capillary morphology 0.00245601467324865 0.0193082348535427 1.0540973752755 0.645161290322581 11.2 11 2 inner cell mass degeneration 0.00245601467324865 0.0193082348535427 1.0540973752755 0.645161290322581 11.2 11 2 abnormal podocyte morphology 0.00245601467324865 0.0193082348535427 1.0540973752755 0.645161290322581 11.2 11 2 preaxial polydactyly 0.00245601467324865 0.0193082348535427 1.0540973752755 0.645161290322581 11.2 11 2 trabecula carnea hypoplasia 0.000285153619789128 0.00336170440391211 1.05292615596963 0.644444444444444 11.2 11 2 abnormal metabolism 0.000285153619789128 0.00336170440391211 1.05292615596963 0.644444444444444 11.2 11 2 abnormal fertility/fecundity 4.28210744686484e-06 8.6632978073804e-05 1.05193142176466 0.643835616438356 11.2 11 2 abnormal vitelline vasculature morphology 8.79007282996944e-09 3.31292517644681e-07 1.05134755603565 0.643478260869565 11.2 11 2 abnormal eye development 5.86061829798564e-05 0.000870345553208315 1.05033274179237 0.642857142857143 11.2 11 2 myoclonus 0.00426016976416344 0.0296062900972343 1.05033274179237 0.642857142857143 11.2 11 2 abnormal somite shape 0.00426016976416344 0.0296062900972343 1.05033274179237 0.642857142857143 11.2 11 2 abnormal brainstem morphology 0.00426016976416344 0.0296062900972343 1.05033274179237 0.642857142857143 11.2 11 2 abnormal renal tubule epithelium morphology 0.00426016976416344 0.0296062900972343 1.05033274179237 0.642857142857143 11.2 11 2 prolonged QRS complex duration 0.00426016976416344 0.0296062900972343 1.05033274179237 0.642857142857143 11.2 11 2 midline facial cleft 0.0417393781852056 0.165032564239577 1.05033274179237 0.642857142857143 11.2 11 2 abnormal kidney blood vessel morphology 0.0417393781852056 0.165032564239577 1.05033274179237 0.642857142857143 11.2 11 2 abnormal sagittal suture morphology 0.0417393781852056 0.165032564239577 1.05033274179237 0.642857142857143 11.2 11 2 increased circulating growth hormone level 0.0417393781852056 0.165032564239577 1.05033274179237 0.642857142857143 11.2 11 2 abnormal viscerocranium morphology 0.0417393781852056 0.165032564239577 1.05033274179237 0.642857142857143 11.2 11 2 spina bifida occulta 0.0417393781852056 0.165032564239577 1.05033274179237 0.642857142857143 11.2 11 2 sternebra fusion 0.0417393781852056 0.165032564239577 1.05033274179237 0.642857142857143 11.2 11 2 abnormal renal reabsorbtion 0.0417393781852056 0.165032564239577 1.05033274179237 0.642857142857143 11.2 11 2 pulmonary alveolar hemorrhage 0.0417393781852056 0.165032564239577 1.05033274179237 0.642857142857143 11.2 11 2 decreased compact bone area 0.0417393781852056 0.165032564239577 1.05033274179237 0.642857142857143 11.2 11 2 cleft palate 1.15471921611379e-09 5.22248009106011e-08 1.04766013939595 0.641221374045801 11.2 11 2 abnormal kidney morphology 2.5653713780119e-12 1.72469224400125e-10 1.04566459627329 0.64 11.2 11 2 increased circulating chloride level 0.000169348758339386 0.00214926038963889 1.04566459627329 0.64 11.2 11 2 abnormal circulating protein level 0.000169348758339386 0.00214926038963889 1.04566459627329 0.64 11.2 11 2 decreased oocyte number 0.000169348758339386 0.00214926038963889 1.04566459627329 0.64 11.2 11 2 abnormal keratinocyte physiology 0.00742216859680078 0.0468595035140659 1.04566459627329 0.64 11.2 11 2 abnormal cochlear outer hair cell morphology 0.00742216859680078 0.0468595035140659 1.04566459627329 0.64 11.2 11 2 abnormal embryo development 7.01440958610384e-10 3.34317655360234e-08 1.04518405188162 0.639705882352941 11.2 11 2 heart right ventricle hypertrophy 0.00143428976747749 0.0124674399737622 1.04384920634921 0.638888888888889 11.2 11 2 renal hypoplasia 0.00143428976747749 0.0124674399737622 1.04384920634921 0.638888888888889 11.2 11 2 decreased total body fat amount 8.44583371641993e-22 2.47164839642289e-19 1.04194685163834 0.637724550898204 11.2 11 2 thymus hypoplasia 7.12315004385625e-10 3.34317655360234e-08 1.04187595643172 0.63768115942029 11.2 11 2 polyuria 4.40520140567171e-06 8.87282469361003e-05 1.0397233201581 0.636363636363636 11.2 11 2 decreased circulating total protein level 0.000100580906249015 0.00137367734284307 1.0397233201581 0.636363636363636 11.2 11 2 omphalocele 0.000491674528416798 0.00527172581653787 1.0397233201581 0.636363636363636 11.2 11 2 lethality, incomplete penetrance 0.000491674528416798 0.00527172581653787 1.0397233201581 0.636363636363636 11.2 11 2 abnormal aorta morphology 0.00246858539396376 0.0193100822876882 1.0397233201581 0.636363636363636 11.2 11 2 abnormal QRS complex 0.00246858539396376 0.0193100822876882 1.0397233201581 0.636363636363636 11.2 11 2 testis hypoplasia 0.0130009190085802 0.0710388792309752 1.0397233201581 0.636363636363636 11.2 11 2 increased skin papilloma incidence 0.0130009190085802 0.0710388792309752 1.0397233201581 0.636363636363636 11.2 11 2 abnormal chorion morphology 0.0130009190085802 0.0710388792309752 1.0397233201581 0.636363636363636 11.2 11 2 increased myocardial infarction size 0.0130009190085802 0.0710388792309752 1.0397233201581 0.636363636363636 11.2 11 2 parakeratosis 0.0130009190085802 0.0710388792309752 1.0397233201581 0.636363636363636 11.2 11 2 cleft upper lip 0.0130009190085802 0.0710388792309752 1.0397233201581 0.636363636363636 11.2 11 2 abnormal mesenteric lymph node morphology 0.0130009190085802 0.0710388792309752 1.0397233201581 0.636363636363636 11.2 11 2 increased adenoma incidence 0.0130009190085802 0.0710388792309752 1.0397233201581 0.636363636363636 11.2 11 2 absent semicircular canals 0.076463919822826 0.252744604400809 1.0397233201581 0.636363636363636 11.2 11 2 abnormal stomach epithelium morphology 0.076463919822826 0.252744604400809 1.0397233201581 0.636363636363636 11.2 11 2 abnormal enteric ganglia morphology 0.076463919822826 0.252744604400809 1.0397233201581 0.636363636363636 11.2 11 2 abnormal hemoglobin 0.076463919822826 0.252744604400809 1.0397233201581 0.636363636363636 11.2 11 2 focal hepatic necrosis 0.076463919822826 0.252744604400809 1.0397233201581 0.636363636363636 11.2 11 2 vasculitis 0.076463919822826 0.252744604400809 1.0397233201581 0.636363636363636 11.2 11 2 secondary sex reversal 0.076463919822826 0.252744604400809 1.0397233201581 0.636363636363636 11.2 11 2 abnormal fear/anxiety-related behavior 0.076463919822826 0.252744604400809 1.0397233201581 0.636363636363636 11.2 11 2 fatigue 0.076463919822826 0.252744604400809 1.0397233201581 0.636363636363636 11.2 11 2 patent ductus arteriosus 0.076463919822826 0.252744604400809 1.0397233201581 0.636363636363636 11.2 11 2 impaired luteinization 0.076463919822826 0.252744604400809 1.0397233201581 0.636363636363636 11.2 11 2 dilated renal glomerular capsule 0.076463919822826 0.252744604400809 1.0397233201581 0.636363636363636 11.2 11 2 pathological neovascularization 0.076463919822826 0.252744604400809 1.0397233201581 0.636363636363636 11.2 11 2 abnormal coronal suture morphology 0.076463919822826 0.252744604400809 1.0397233201581 0.636363636363636 11.2 11 2 increased circulating triiodothyronine level 0.076463919822826 0.252744604400809 1.0397233201581 0.636363636363636 11.2 11 2 abnormal aorta smooth muscle morphology 0.076463919822826 0.252744604400809 1.0397233201581 0.636363636363636 11.2 11 2 decreased colon length 0.076463919822826 0.252744604400809 1.0397233201581 0.636363636363636 11.2 11 2 reduced sympathetic cervical ganglion size 0.076463919822826 0.252744604400809 1.0397233201581 0.636363636363636 11.2 11 2 increased circulating aspartate transaminase level 3.5354392192189e-05 0.000554852054120316 1.03736567090604 0.634920634920635 11.2 11 2 abnormal testis morphology 2.58717264354362e-08 9.00082790323741e-07 1.03714015662976 0.634782608695652 11.2 11 2 decreased grip strength 1.68038531696829e-14 1.81737325041679e-12 1.03701040868998 0.634703196347032 11.2 11 2 abnormal mammary gland development 0.000839555561514948 0.0080945521677071 1.03610059081957 0.634146341463415 11.2 11 2 increased circulating free fatty acid level 1.25011227019514e-05 0.000226156674335303 1.03553932289388 0.633802816901408 11.2 11 2 abnormal retina morphology 7.79349141721222e-14 6.9236821072555e-12 1.03477225672878 0.633333333333333 11.2 11 2 increased erythrocyte cell number 5.97570251594731e-05 0.000879559763811772 1.03477225672878 0.633333333333333 11.2 11 2 abnormal lactation 0.00426092536876779 0.0296062900972343 1.03477225672878 0.633333333333333 11.2 11 2 abnormal fat pad morphology 0.00426092536876779 0.0296062900972343 1.03477225672878 0.633333333333333 11.2 11 2 abnormal cellular respiration 0.00426092536876779 0.0296062900972343 1.03477225672878 0.633333333333333 11.2 11 2 abnormal eye morphology 1.21861682813488e-09 5.46181866664055e-08 1.0343804459538 0.633093525179856 11.2 11 2 abnormal vertebrae morphology 7.24990661601949e-08 2.26844562356585e-06 1.03427260812582 0.63302752293578 11.2 11 2 abnormal visceral yolk sac morphology 4.44104387287481e-06 8.90894889820653e-05 1.03408286815001 0.632911392405063 11.2 11 2 abnormal craniofacial development 0.00028976559084788 0.00339996182657595 1.03366079350995 0.63265306122449 11.2 11 2 incomplete embryo turning 0.00010105847386544 0.00137367734284307 1.03190585158549 0.631578947368421 11.2 11 2 decreased brain weight 0.00010105847386544 0.00137367734284307 1.03190585158549 0.631578947368421 11.2 11 2 abnormal facial morphology 0.00010105847386544 0.00137367734284307 1.03190585158549 0.631578947368421 11.2 11 2 incomplete somite formation 0.00143594836280718 0.0124674399737622 1.03190585158549 0.631578947368421 11.2 11 2 irregular coat pigmentation 0.0229270821541773 0.106755968333675 1.03190585158549 0.631578947368421 11.2 11 2 shiny skin 0.0229270821541773 0.106755968333675 1.03190585158549 0.631578947368421 11.2 11 2 increased malignant tumor incidence 0.0229270821541773 0.106755968333675 1.03190585158549 0.631578947368421 11.2 11 2 abnormal neurotransmitter level 0.0229270821541773 0.106755968333675 1.03190585158549 0.631578947368421 11.2 11 2 abnormal neural crest cell migration 0.0229270821541773 0.106755968333675 1.03190585158549 0.631578947368421 11.2 11 2 abnormal optic vesicle formation 0.0229270821541773 0.106755968333675 1.03190585158549 0.631578947368421 11.2 11 2 abnormal cochlear inner hair cell morphology 0.0229270821541773 0.106755968333675 1.03190585158549 0.631578947368421 11.2 11 2 absent amnion 0.0229270821541773 0.106755968333675 1.03190585158549 0.631578947368421 11.2 11 2 decreased eye pigmentation 0.0229270821541773 0.106755968333675 1.03190585158549 0.631578947368421 11.2 11 2 eyelids fail to open 0.0229270821541773 0.106755968333675 1.03190585158549 0.631578947368421 11.2 11 2 Leydig cell hypoplasia 0.0229270821541773 0.106755968333675 1.03190585158549 0.631578947368421 11.2 11 2 decreased body length 2.36724554120878e-17 4.36186909907913e-15 1.03159201160629 0.631386861313869 11.2 11 2 abnormal spermatogenesis 4.59771636818393e-12 2.97060245866429e-10 1.03003645692682 0.630434782608696 11.2 11 2 astrocytosis 1.25582102380007e-05 0.000226366289616136 1.02954990215264 0.63013698630137 11.2 11 2 abnormal axon morphology 1.22023474705928e-07 3.64781378594157e-06 1.02872095698183 0.62962962962963 11.2 11 2 abnormal long bone epiphyseal plate proliferative zone 0.000171006035520398 0.00216477106034092 1.02872095698183 0.62962962962963 11.2 11 2 abnormal trigeminal nerve morphology 0.00737943383887038 0.0467900370237999 1.02872095698183 0.62962962962963 11.2 11 2 abnormal fetal cardiomyocyte proliferation 0.00737943383887038 0.0467900370237999 1.02872095698183 0.62962962962963 11.2 11 2 decreased circulating fructosamine level 0.00737943383887038 0.0467900370237999 1.02872095698183 0.62962962962963 11.2 11 2 thick interventricular septum 0.00737943383887038 0.0467900370237999 1.02872095698183 0.62962962962963 11.2 11 2 increased tumor incidence 1.58092010776087e-08 5.78314524713996e-07 1.02774494089361 0.629032258064516 11.2 11 2 abnormal dermal layer morphology 0.00246058711500423 0.0193082348535427 1.02699201419698 0.628571428571429 11.2 11 2 abnormal artery morphology 0.00246058711500423 0.0193082348535427 1.02699201419698 0.628571428571429 11.2 11 2 increased circulating serum albumin level 0.00246058711500423 0.0193082348535427 1.02699201419698 0.628571428571429 11.2 11 2 decreased body weight 1.01042056412151e-72 2.51342115325226e-69 1.02676577128007 0.62843295638126 11.2 11 2 absent gastric milk in neonates 7.48770934504413e-06 0.000141103613604525 1.02639353400223 0.628205128205128 11.2 11 2 abnormal vasculogenesis 0.000838098771007049 0.0080945521677071 1.02590639895999 0.627906976744186 11.2 11 2 abnormal homeostasis 0.000838098771007049 0.0080945521677071 1.02590639895999 0.627906976744186 11.2 11 2 decreased leukocyte cell number 3.43263686327248e-09 1.41135275989922e-07 1.02562905200163 0.627737226277372 11.2 11 2 abnormal blood vessel morphology 1.24030320204663e-09 5.5093825269482e-08 1.02538230884558 0.627586206896552 11.2 11 2 impaired hematopoiesis 0.000289549306570883 0.00339996182657595 1.02516136889538 0.627450980392157 11.2 11 2 impaired glucose tolerance 3.86888271025788e-15 4.47620732175185e-13 1.02115683229814 0.625 11.2 11 2 liver inflammation 4.40476211760176e-08 1.46091276900458e-06 1.02115683229814 0.625 11.2 11 2 abnormal coat/hair pigmentation 1.22449226583365e-07 3.64781378594157e-06 1.02115683229814 0.625 11.2 11 2 thymus atrophy 0.000490595776249265 0.00527172581653787 1.02115683229814 0.625 11.2 11 2 abnormal vertebral body morphology 0.00422531229150616 0.0296062900972343 1.02115683229814 0.625 11.2 11 2 abnormal embryonic hematopoiesis 0.00422531229150616 0.0296062900972343 1.02115683229814 0.625 11.2 11 2 ocular hypertelorism 0.0128316852332417 0.0709269187800836 1.02115683229814 0.625 11.2 11 2 hemolytic anemia 0.0128316852332417 0.0709269187800836 1.02115683229814 0.625 11.2 11 2 increased hemangiosarcoma incidence 0.0128316852332417 0.0709269187800836 1.02115683229814 0.625 11.2 11 2 hypopigmentation 0.0128316852332417 0.0709269187800836 1.02115683229814 0.625 11.2 11 2 abnormal inner cell mass apoptosis 0.0128316852332417 0.0709269187800836 1.02115683229814 0.625 11.2 11 2 abnormal lung saccule morphology 0.0128316852332417 0.0709269187800836 1.02115683229814 0.625 11.2 11 2 absent mandible 0.0407848275476798 0.165032564239577 1.02115683229814 0.625 11.2 11 2 abnormal meiosis 0.0407848275476798 0.165032564239577 1.02115683229814 0.625 11.2 11 2 abnormal olfaction 0.0407848275476798 0.165032564239577 1.02115683229814 0.625 11.2 11 2 increased intestinal adenocarcinoma incidence 0.0407848275476798 0.165032564239577 1.02115683229814 0.625 11.2 11 2 small pancreas 0.0407848275476798 0.165032564239577 1.02115683229814 0.625 11.2 11 2 increased cochlear outer hair cell number 0.0407848275476798 0.165032564239577 1.02115683229814 0.625 11.2 11 2 abnormal thoracic cage shape 0.0407848275476798 0.165032564239577 1.02115683229814 0.625 11.2 11 2 abnormal pulmonary alveolus wall morphology 0.0407848275476798 0.165032564239577 1.02115683229814 0.625 11.2 11 2 abnormal ear pigmentation 0.143784113150713 0.377387385917969 1.02115683229814 0.625 11.2 11 2 abnormal exoccipital bone morphology 0.143784113150713 0.377387385917969 1.02115683229814 0.625 11.2 11 2 abnormal bone marrow development 0.143784113150713 0.377387385917969 1.02115683229814 0.625 11.2 11 2 enlarged pituitary gland 0.143784113150713 0.377387385917969 1.02115683229814 0.625 11.2 11 2 abnormal pupil morphology 0.143784113150713 0.377387385917969 1.02115683229814 0.625 11.2 11 2 absent eyelids 0.143784113150713 0.377387385917969 1.02115683229814 0.625 11.2 11 2 spinning 0.143784113150713 0.377387385917969 1.02115683229814 0.625 11.2 11 2 abnormal erythrocyte cell number 0.143784113150713 0.377387385917969 1.02115683229814 0.625 11.2 11 2 abnormal thyroid physiology 0.143784113150713 0.377387385917969 1.02115683229814 0.625 11.2 11 2 hypospadia 0.143784113150713 0.377387385917969 1.02115683229814 0.625 11.2 11 2 absent tympanic ring 0.143784113150713 0.377387385917969 1.02115683229814 0.625 11.2 11 2 abnormal cellular cholesterol metabolism 0.143784113150713 0.377387385917969 1.02115683229814 0.625 11.2 11 2 decreased susceptibility to age related obesity 0.143784113150713 0.377387385917969 1.02115683229814 0.625 11.2 11 2 abnormal perineum morphology 0.143784113150713 0.377387385917969 1.02115683229814 0.625 11.2 11 2 increased cardiac output 0.143784113150713 0.377387385917969 1.02115683229814 0.625 11.2 11 2 abnormal platelet shape 0.143784113150713 0.377387385917969 1.02115683229814 0.625 11.2 11 2 abnormal lateral ganglionic eminence morphology 0.143784113150713 0.377387385917969 1.02115683229814 0.625 11.2 11 2 long femur 0.143784113150713 0.377387385917969 1.02115683229814 0.625 11.2 11 2 small frontal bone 0.143784113150713 0.377387385917969 1.02115683229814 0.625 11.2 11 2 abnormal NK cell morphology 0.143784113150713 0.377387385917969 1.02115683229814 0.625 11.2 11 2 abnormal choroid pigmentation 0.143784113150713 0.377387385917969 1.02115683229814 0.625 11.2 11 2 non-pigmented tail tip 0.143784113150713 0.377387385917969 1.02115683229814 0.625 11.2 11 2 abnormal vertebral body development 0.143784113150713 0.377387385917969 1.02115683229814 0.625 11.2 11 2 ocular hypertension 0.143784113150713 0.377387385917969 1.02115683229814 0.625 11.2 11 2 absent outer ear 0.143784113150713 0.377387385917969 1.02115683229814 0.625 11.2 11 2 abnormal corneocyte envelope morphology 0.143784113150713 0.377387385917969 1.02115683229814 0.625 11.2 11 2 hypergranulosis 0.143784113150713 0.377387385917969 1.02115683229814 0.625 11.2 11 2 decreased hippocampus pyramidal cell number 0.143784113150713 0.377387385917969 1.02115683229814 0.625 11.2 11 2 increased caudal vertebrae number 0.143784113150713 0.377387385917969 1.02115683229814 0.625 11.2 11 2 abnormal lateral plate mesoderm morphology 0.143784113150713 0.377387385917969 1.02115683229814 0.625 11.2 11 2 decreased quadriceps weight 0.143784113150713 0.377387385917969 1.02115683229814 0.625 11.2 11 2 abnormal hepatic vein morphology 0.143784113150713 0.377387385917969 1.02115683229814 0.625 11.2 11 2 myocardial trabeculae hypoplasia 0.143784113150713 0.377387385917969 1.02115683229814 0.625 11.2 11 2 sinoatrial block 0.143784113150713 0.377387385917969 1.02115683229814 0.625 11.2 11 2 abnormal heart right ventricle pressure 0.143784113150713 0.377387385917969 1.02115683229814 0.625 11.2 11 2 abnormal stomach position or orientation 0.143784113150713 0.377387385917969 1.02115683229814 0.625 11.2 11 2 abnormal branching involved in ureteric bud morphogenesis 0.143784113150713 0.377387385917969 1.02115683229814 0.625 11.2 11 2 increased cardiac stroke volume 0.143784113150713 0.377387385917969 1.02115683229814 0.625 11.2 11 2 prolonged PQ interval 0.143784113150713 0.377387385917969 1.02115683229814 0.625 11.2 11 2 absent hypoglossal canal 0.143784113150713 0.377387385917969 1.02115683229814 0.625 11.2 11 2 retropleural edema 0.143784113150713 0.377387385917969 1.02115683229814 0.625 11.2 11 2 abnormal umbilical vein topology 0.143784113150713 0.377387385917969 1.02115683229814 0.625 11.2 11 2 postnatal growth retardation 4.81961133196532e-35 2.99719579706593e-32 1.01982198676572 0.624183006535948 11.2 11 2 abnormal definitive hematopoiesis 1.59034582432639e-06 3.61277190686017e-05 1.01896079609965 0.623655913978495 11.2 11 2 thin ventricular wall 2.6562028431104e-06 5.72061001925291e-05 1.01661835748792 0.622222222222222 11.2 11 2 edema 9.77498222008533e-11 5.40339294943605e-09 1.01640726563628 0.622093023255814 11.2 11 2 small seminiferous tubules 2.09998127319341e-05 0.000360255408073697 1.01563706563707 0.621621621621622 11.2 11 2 skin inflammation 0.00243561498711267 0.0193082348535427 1.01563706563707 0.621621621621622 11.2 11 2 abnormal tail morphology 5.94486516778868e-05 0.000877617335600851 1.01496800301148 0.621212121212121 11.2 11 2 anemia 1.01411564541404e-12 7.41944902343361e-11 1.01438138412175 0.62085308056872 11.2 11 2 thrombocytopenia 3.42223713705478e-09 1.41135275989922e-07 1.01411437138574 0.620689655172414 11.2 11 2 dermatitis 0.000169334976794537 0.00214926038963889 1.01411437138574 0.620689655172414 11.2 11 2 abnormal outer ear morphology 0.00727325424236079 0.0463903075073653 1.01411437138574 0.620689655172414 11.2 11 2 abnormal hindlimb morphology 0.000486235159677529 0.00524733171235511 1.01298757763975 0.62 11.2 11 2 short stride length 0.000486235159677529 0.00524733171235511 1.01298757763975 0.62 11.2 11 2 kidney inflammation 0.000486235159677529 0.00524733171235511 1.01298757763975 0.62 11.2 11 2 atelectasis 3.5173485214309e-05 0.00055375977513034 1.01252733794069 0.619718309859155 11.2 11 2 corneal opacity 3.5173485214309e-05 0.00055375977513034 1.01252733794069 0.619718309859155 11.2 11 2 decreased body size 1.37532681931294e-43 9.77464418011695e-41 1.01143152913339 0.619047619047619 11.2 11 2 spina bifida 0.00141145100523404 0.0124502992039704 1.01143152913339 0.619047619047619 11.2 11 2 small ears 0.0224205235154288 0.105827423614097 1.01143152913339 0.619047619047619 11.2 11 2 abnormal hematopoietic system physiology 0.0224205235154288 0.105827423614097 1.01143152913339 0.619047619047619 11.2 11 2 embryonic lethality at implantation, complete penetrance 0.0224205235154288 0.105827423614097 1.01143152913339 0.619047619047619 11.2 11 2 increased bone ossification 0.0224205235154288 0.105827423614097 1.01143152913339 0.619047619047619 11.2 11 2 abnormal behavior 5.01474890327645e-16 7.12810736965723e-14 1.01087179945485 0.618705035971223 11.2 11 2 abnormal myocardial fiber morphology 1.57322596135808e-06 3.59027484300755e-05 1.01062944227444 0.618556701030928 11.2 11 2 abnormal rostral-caudal axis patterning 0.000285027673388353 0.00336170440391211 1.01001693958216 0.618181818181818 11.2 11 2 enlarged spleen 1.81112472984045e-16 2.90656307450201e-14 1.0098106452726 0.618055555555556 11.2 11 2 kinked tail 9.37740566094627e-07 2.32102453548297e-05 1.00914322250639 0.617647058823529 11.2 11 2 pericardial edema 5.8903455934297e-05 0.000872156825217642 1.00914322250639 0.617647058823529 11.2 11 2 premature death 4.19858161228019e-46 3.48132392018233e-43 1.00763628887398 0.616724738675958 11.2 11 2 abnormal incisor morphology 0.000167485325565189 0.00214752447084231 1.00754140786749 0.616666666666667 11.2 11 2 abnormal seminiferous tubule morphology 5.60115589816671e-09 2.17701176510777e-07 1.00716838254063 0.616438356164384 11.2 11 2 abnormal heart ventricle morphology 2.06131107867036e-05 0.000354845073231316 1.00544672718586 0.615384615384615 11.2 11 2 small lens 0.00239682330421945 0.0191707330200832 1.00544672718586 0.615384615384615 11.2 11 2 decreased trabecular bone volume 0.00239682330421945 0.0191707330200832 1.00544672718586 0.615384615384615 11.2 11 2 decreased kidney weight 0.000479801192814988 0.00521352423926354 1.00544672718586 0.615384615384615 11.2 11 2 abnormal nasal bone morphology 0.0125545789575645 0.0704160431949081 1.00544672718586 0.615384615384615 11.2 11 2 ventricular hypoplasia 0.0125545789575645 0.0704160431949081 1.00544672718586 0.615384615384615 11.2 11 2 abnormal kidney cortex morphology 0.0125545789575645 0.0704160431949081 1.00544672718586 0.615384615384615 11.2 11 2 abnormal erythrocyte osmotic lysis 0.0125545789575645 0.0704160431949081 1.00544672718586 0.615384615384615 11.2 11 2 uterus hypoplasia 0.073397685524475 0.249251525927825 1.00544672718586 0.615384615384615 11.2 11 2 abnormal telomere length 0.073397685524475 0.249251525927825 1.00544672718586 0.615384615384615 11.2 11 2 axonal dystrophy 0.073397685524475 0.249251525927825 1.00544672718586 0.615384615384615 11.2 11 2 abnormal retinal inner plexiform layer morphology 0.073397685524475 0.249251525927825 1.00544672718586 0.615384615384615 11.2 11 2 abnormal exocrine pancreas morphology 0.073397685524475 0.249251525927825 1.00544672718586 0.615384615384615 11.2 11 2 increased renin activity 0.073397685524475 0.249251525927825 1.00544672718586 0.615384615384615 11.2 11 2 abnormal aorta tunica media morphology 0.073397685524475 0.249251525927825 1.00544672718586 0.615384615384615 11.2 11 2 abnormal heart morphology 3.54141111396595e-13 2.7965905225366e-11 1.00435858137721 0.614718614718615 11.2 11 2 abnormal craniofacial bone morphology 0.000281075626430619 0.00333735379831105 1.00324180015256 0.614035087719298 11.2 11 2 increased circulating cholesterol level 2.58933400338398e-10 1.34186840279534e-08 1.00259034443817 0.613636363636364 11.2 11 2 hyperglycemia 7.24772894350391e-06 0.000137100576022555 1.00259034443817 0.613636363636364 11.2 11 2 osteoporosis 0.00138830197982686 0.0123115906410671 1.00259034443817 0.613636363636364 11.2 11 2 abnormal limb morphology 3.43734643724633e-05 0.0005446114180032 1.00209523809524 0.613333333333333 11.2 11 2 abnormal cranial ganglia morphology 0.0071187006366731 0.0457565060302954 1.00139250651172 0.612903225806452 11.2 11 2 abnormal respiratory system physiology 0.000807696068988292 0.0078635771882911 1.00031689694511 0.612244897959184 11.2 11 2 decreased urine osmolality 0.000807696068988292 0.0078635771882911 1.00031689694511 0.612244897959184 11.2 11 2 reduced female fertility 5.71585154352723e-13 4.37482483523815e-11 1.00002944956093 0.612068965517241 11.2 11 2 abnormal cranium morphology 4.19240860487522e-08 1.39981428250028e-06 0.999819226847131 0.611940298507463 11.2 11 2 abnormal craniofacial morphology 1.52150624707951e-06 3.52069468800956e-05 0.999345715491769 0.611650485436893 11.2 11 2 increased heart weight 2.5049327932432e-08 8.83832669956379e-07 0.999117476205371 0.611510791366906 11.2 11 2 diluted coat color 0.000471614183304904 0.00514535210952171 0.998464458247067 0.611111111111111 11.2 11 2 neurodegeneration 0.000471614183304904 0.00514535210952171 0.998464458247067 0.611111111111111 11.2 11 2 abnormal pharyngeal arch morphology 0.00407334008968911 0.029032760667913 0.998464458247067 0.611111111111111 11.2 11 2 abnormal megakaryocyte differentiation 0.0394078774551966 0.162835706262129 0.998464458247067 0.611111111111111 11.2 11 2 abnormal radius morphology 0.0394078774551966 0.162835706262129 0.998464458247067 0.611111111111111 11.2 11 2 abnormal iron level 0.0394078774551966 0.162835706262129 0.998464458247067 0.611111111111111 11.2 11 2 abnormal thyroid cartilage morphology 0.0394078774551966 0.162835706262129 0.998464458247067 0.611111111111111 11.2 11 2 abnormal thymus medulla morphology 0.0394078774551966 0.162835706262129 0.998464458247067 0.611111111111111 11.2 11 2 abnormal white adipose tissue morphology 0.0394078774551966 0.162835706262129 0.998464458247067 0.611111111111111 11.2 11 2 abnormal metacarpal bone morphology 0.0394078774551966 0.162835706262129 0.998464458247067 0.611111111111111 11.2 11 2 increased circulating renin level 0.0394078774551966 0.162835706262129 0.998464458247067 0.611111111111111 11.2 11 2 absent inner cell mass 0.0394078774551966 0.162835706262129 0.998464458247067 0.611111111111111 11.2 11 2 decreased pulmonary respiratory rate 0.0394078774551966 0.162835706262129 0.998464458247067 0.611111111111111 11.2 11 2 increased gastrointestinal tumor incidence 0.0394078774551966 0.162835706262129 0.998464458247067 0.611111111111111 11.2 11 2 atrioventricular block 0.0394078774551966 0.162835706262129 0.998464458247067 0.611111111111111 11.2 11 2 primary atelectasis 0.0394078774551966 0.162835706262129 0.998464458247067 0.611111111111111 11.2 11 2 decreased birth weight 4.24157783619635e-06 8.6482990717528e-05 0.997508989865969 0.610526315789474 11.2 11 2 short humerus 0.00234694827404188 0.0190935682480544 0.996250568095743 0.609756097560976 11.2 11 2 abnormal cholesterol homeostasis 0.00234694827404188 0.0190935682480544 0.996250568095743 0.609756097560976 11.2 11 2 decreased circulating LDL cholesterol level 0.000162184795868596 0.00210122229022464 0.995627911490683 0.609375 11.2 11 2 increased sacral vertebrae number 0.000162184795868596 0.00210122229022464 0.995627911490683 0.609375 11.2 11 2 abnormal myelin sheath morphology 0.0013596150579051 0.0120787230590677 0.994517958412098 0.608695652173913 11.2 11 2 abnormal blood vessel physiology 0.0217399810310491 0.104196922571743 0.994517958412098 0.608695652173913 11.2 11 2 abnormal ulna morphology 0.0217399810310491 0.104196922571743 0.994517958412098 0.608695652173913 11.2 11 2 abnormal chondrocyte physiology 0.0217399810310491 0.104196922571743 0.994517958412098 0.608695652173913 11.2 11 2 abnormal vertebral artery topology 0.0217399810310491 0.104196922571743 0.994517958412098 0.608695652173913 11.2 11 2 decreased litter size 5.56626536929708e-15 6.29367504823931e-13 0.994265157710926 0.608540925266904 11.2 11 2 abnormal heart development 5.19010994653644e-09 2.0656637587215e-07 0.992719553424011 0.607594936708861 11.2 11 2 postnatal lethality, incomplete penetrance 1.54570944137447e-28 6.40825372569833e-26 0.99239185110664 0.607394366197183 11.2 11 2 hydronephrosis 1.96536185647301e-05 0.000339502612359486 0.991980922803904 0.607142857142857 11.2 11 2 lymphoid hyperplasia 0.0122001146815992 0.0695252812611183 0.991980922803904 0.607142857142857 11.2 11 2 insulin resistance 1.10493061268986e-07 3.37241091909942e-06 0.99021268586486 0.606060606060606 11.2 11 2 decreased bone mineral density 6.63108753564055e-14 6.10919638700217e-12 0.98890977443609 0.605263157894737 11.2 11 2 increased exploration in new environment 3.25591659866278e-05 0.000520841963933998 0.988378958668814 0.604938271604938 11.2 11 2 hypoactivity 5.20210926590238e-19 1.12523885208106e-16 0.988111438786101 0.604774535809019 11.2 11 2 abnormal blood circulation 0.00228834265758119 0.0187245143445171 0.987909865665174 0.604651162790698 11.2 11 2 abnormal pancreatic islet morphology 0.000772208032756664 0.00768346992592881 0.986476034220087 0.60377358490566 11.2 11 2 thrombocytosis 0.000451115745442047 0.00496526733091633 0.985944527736132 0.603448275862069 11.2 11 2 decreased circulating alanine transaminase level 0.000155250426250057 0.00202722013279274 0.985116002922908 0.602941176470588 11.2 11 2 increased bone mineral density 1.38606965160927e-06 3.22228809194211e-05 0.983202330566702 0.601769911504425 11.2 11 2 small testis 6.00741967090344e-14 5.639040162782e-12 0.982678458907192 0.601449275362319 11.2 11 2 spleen hypoplasia 3.83282578587923e-06 7.94512845197882e-05 0.980310559006211 0.6 11.2 11 2 abnormal learning/memory/conditioning 0.000751493948179736 0.00749234948335508 0.980310559006211 0.6 11.2 11 2 abnormal platelet physiology 0.000751493948179736 0.00749234948335508 0.980310559006211 0.6 11.2 11 2 abnormal cell proliferation 0.037783798493388 0.160523478223868 0.980310559006211 0.6 11.2 11 2 abnormal vascular regression 0.037783798493388 0.160523478223868 0.980310559006211 0.6 11.2 11 2 waved hair 0.037783798493388 0.160523478223868 0.980310559006211 0.6 11.2 11 2 abnormal circulating enzyme level 0.037783798493388 0.160523478223868 0.980310559006211 0.6 11.2 11 2 spleen atrophy 0.037783798493388 0.160523478223868 0.980310559006211 0.6 11.2 11 2 abnormal heart right ventricle morphology 0.037783798493388 0.160523478223868 0.980310559006211 0.6 11.2 11 2 decreased circulating VLDL cholesterol level 0.037783798493388 0.160523478223868 0.980310559006211 0.6 11.2 11 2 abnormal induced retinal neovascularization 0.037783798493388 0.160523478223868 0.980310559006211 0.6 11.2 11 2 abnormal auchene hair morphology 0.134242954451774 0.377387385917969 0.980310559006211 0.6 11.2 11 2 retarded hair growth 0.134242954451774 0.377387385917969 0.980310559006211 0.6 11.2 11 2 enlarged testis 0.134242954451774 0.377387385917969 0.980310559006211 0.6 11.2 11 2 abnormal epidermis suprabasal layer morphology 0.134242954451774 0.377387385917969 0.980310559006211 0.6 11.2 11 2 abnormal gland morphology 0.134242954451774 0.377387385917969 0.980310559006211 0.6 11.2 11 2 abnormal respiratory mechanics 0.134242954451774 0.377387385917969 0.980310559006211 0.6 11.2 11 2 decreased circulating parathyroid hormone level 0.134242954451774 0.377387385917969 0.980310559006211 0.6 11.2 11 2 rickets 0.134242954451774 0.377387385917969 0.980310559006211 0.6 11.2 11 2 absent CD4-positive, alpha beta T cells 0.134242954451774 0.377387385917969 0.980310559006211 0.6 11.2 11 2 absent pharyngeal arches 0.134242954451774 0.377387385917969 0.980310559006211 0.6 11.2 11 2 abnormal ear physiology 0.134242954451774 0.377387385917969 0.980310559006211 0.6 11.2 11 2 abnormal reproductive system development 0.134242954451774 0.377387385917969 0.980310559006211 0.6 11.2 11 2 abnormal embryonic erythrocyte morphology 0.134242954451774 0.377387385917969 0.980310559006211 0.6 11.2 11 2 abnormal deltoid tuberosity morphology 0.134242954451774 0.377387385917969 0.980310559006211 0.6 11.2 11 2 abnormal respiratory conducting tube morphology 0.134242954451774 0.377387385917969 0.980310559006211 0.6 11.2 11 2 abnormal gonadal fat pad morphology 0.134242954451774 0.377387385917969 0.980310559006211 0.6 11.2 11 2 increased susceptibility to atherosclerosis 0.134242954451774 0.377387385917969 0.980310559006211 0.6 11.2 11 2 tachypnea 0.134242954451774 0.377387385917969 0.980310559006211 0.6 11.2 11 2 protruding tongue 0.134242954451774 0.377387385917969 0.980310559006211 0.6 11.2 11 2 abnormal hippocampus neuron morphology 0.134242954451774 0.377387385917969 0.980310559006211 0.6 11.2 11 2 abnormal retinal blood vessel pattern 0.134242954451774 0.377387385917969 0.980310559006211 0.6 11.2 11 2 umbilical hernia 0.134242954451774 0.377387385917969 0.980310559006211 0.6 11.2 11 2 increased T-helper 17 cell number 0.134242954451774 0.377387385917969 0.980310559006211 0.6 11.2 11 2 abnormal vibrissa follicle morphology 0.134242954451774 0.377387385917969 0.980310559006211 0.6 11.2 11 2 increased kidney iron level 0.134242954451774 0.377387385917969 0.980310559006211 0.6 11.2 11 2 abnormal heart and great artery attachment 0.134242954451774 0.377387385917969 0.980310559006211 0.6 11.2 11 2 thick aortic valve cusps 0.134242954451774 0.377387385917969 0.980310559006211 0.6 11.2 11 2 decreased trabecular bone connectivity density 0.134242954451774 0.377387385917969 0.980310559006211 0.6 11.2 11 2 domed cranium 0.000151335468514072 0.00199178295200399 0.980310559006211 0.6 11.2 11 2 epidermal hyperplasia 0.000439300292036751 0.00487839051982775 0.980310559006211 0.6 11.2 11 2 abnormal eating behavior 0.000439300292036751 0.00487839051982775 0.980310559006211 0.6 11.2 11 2 increased B cell derived lymphoma incidence 0.00128988743295444 0.0115271365633687 0.980310559006211 0.6 11.2 11 2 abnormal axon extension 0.00128988743295444 0.0115271365633687 0.980310559006211 0.6 11.2 11 2 irregular heartbeat 0.00222301502974418 0.0183104300877108 0.980310559006211 0.6 11.2 11 2 abnormal cell migration 0.00222301502974418 0.0183104300877108 0.980310559006211 0.6 11.2 11 2 thick pulmonary interalveolar septum 0.00671088539318265 0.0435857112677332 0.980310559006211 0.6 11.2 11 2 holoprosencephaly 0.00671088539318265 0.0435857112677332 0.980310559006211 0.6 11.2 11 2 abnormal hippocampus pyramidal cell morphology 0.00671088539318265 0.0435857112677332 0.980310559006211 0.6 11.2 11 2 decreased bone volume 0.00671088539318265 0.0435857112677332 0.980310559006211 0.6 11.2 11 2 increased metastatic potential 0.0117917475527503 0.0672751652235466 0.980310559006211 0.6 11.2 11 2 emphysema 0.0117917475527503 0.0672751652235466 0.980310559006211 0.6 11.2 11 2 disorganized myocardium 0.0117917475527503 0.0672751652235466 0.980310559006211 0.6 11.2 11 2 liver hemorrhage 0.0117917475527503 0.0672751652235466 0.980310559006211 0.6 11.2 11 2 abnormal optic cup morphology 0.0117917475527503 0.0672751652235466 0.980310559006211 0.6 11.2 11 2 abnormal egg cylinder morphology 0.0209459601879029 0.100877204196338 0.980310559006211 0.6 11.2 11 2 decreased placenta weight 0.0209459601879029 0.100877204196338 0.980310559006211 0.6 11.2 11 2 abnormal vertebrae development 0.0209459601879029 0.100877204196338 0.980310559006211 0.6 11.2 11 2 abnormal energy expenditure 0.0209459601879029 0.100877204196338 0.980310559006211 0.6 11.2 11 2 increased liver glycogen level 0.0209459601879029 0.100877204196338 0.980310559006211 0.6 11.2 11 2 abnormal fontanelle morphology 0.0697796821712227 0.245338458517196 0.980310559006211 0.6 11.2 11 2 absent incisors 0.0697796821712227 0.245338458517196 0.980310559006211 0.6 11.2 11 2 abnormal pup retrieval 0.0697796821712227 0.245338458517196 0.980310559006211 0.6 11.2 11 2 placental labyrinth hypoplasia 0.0697796821712227 0.245338458517196 0.980310559006211 0.6 11.2 11 2 altered righting response 0.0697796821712227 0.245338458517196 0.980310559006211 0.6 11.2 11 2 abnormal glial cell morphology 0.0697796821712227 0.245338458517196 0.980310559006211 0.6 11.2 11 2 abnormal pericyte morphology 0.0697796821712227 0.245338458517196 0.980310559006211 0.6 11.2 11 2 abnormal ear development 0.0697796821712227 0.245338458517196 0.980310559006211 0.6 11.2 11 2 abnormal olfactory nerve morphology 0.0697796821712227 0.245338458517196 0.980310559006211 0.6 11.2 11 2 abnormal dendritic cell morphology 0.0697796821712227 0.245338458517196 0.980310559006211 0.6 11.2 11 2 abnormal cerebral aqueduct morphology 0.0697796821712227 0.245338458517196 0.980310559006211 0.6 11.2 11 2 absent chorion 0.0697796821712227 0.245338458517196 0.980310559006211 0.6 11.2 11 2 abnormal secondary palate development 0.0697796821712227 0.245338458517196 0.980310559006211 0.6 11.2 11 2 ostium primum atrial septal defect 0.0697796821712227 0.245338458517196 0.980310559006211 0.6 11.2 11 2 herniated liver 0.0697796821712227 0.245338458517196 0.980310559006211 0.6 11.2 11 2 cyanosis 5.75223596192498e-10 2.77838581656085e-08 0.978608630952381 0.598958333333333 11.2 11 2 abnormal retinal pigmentation 3.02542740991018e-05 0.000493491848009939 0.976554579852931 0.597701149425287 11.2 11 2 decreased compact bone thickness 0.000250336892348854 0.00302299222973361 0.975433392045981 0.597014925373134 11.2 11 2 rib fusion 0.000250336892348854 0.00302299222973361 0.975433392045981 0.597014925373134 11.2 11 2 absent vitelline blood vessels 0.000729366822955613 0.00734534401660764 0.974577748719625 0.596491228070175 11.2 11 2 decreased cardiac muscle contractility 6.12759839671618e-06 0.00011724923855255 0.974026516961299 0.596153846153846 11.2 11 2 abnormal neuron morphology 1.03260945777556e-05 0.000188868825457111 0.973709141100445 0.595959595959596 11.2 11 2 increased mean corpuscular hemoglobin 1.03260945777556e-05 0.000188868825457111 0.973709141100445 0.595959595959596 11.2 11 2 pulmonary hypoplasia 0.00215266950489942 0.0177899182506223 0.973358001850139 0.595744680851064 11.2 11 2 hepatic necrosis 0.00215266950489942 0.0177899182506223 0.973358001850139 0.595744680851064 11.2 11 2 abnormal innervation 0.00215266950489942 0.0177899182506223 0.973358001850139 0.595744680851064 11.2 11 2 decreased bone trabecula number 0.00215266950489942 0.0177899182506223 0.973358001850139 0.595744680851064 11.2 11 2 increased or absent threshold for auditory brainstem response 8.08314162398662e-14 7.05502273321639e-12 0.972395710202239 0.595155709342561 11.2 11 2 abnormal myocardium layer morphology 8.4238281705314e-05 0.00118721091071937 0.972037896061011 0.594936708860759 11.2 11 2 abnormal intestine morphology 0.000142887531772118 0.00190070981434837 0.971478932348497 0.594594594594595 11.2 11 2 increased white adipose tissue amount 0.00647533690680123 0.0424997376138999 0.971478932348497 0.594594594594595 11.2 11 2 decreased width of hypertrophic chondrocyte zone 0.00647533690680123 0.0424997376138999 0.971478932348497 0.594594594594595 11.2 11 2 abnormal pulmonary alveolus morphology 1.00340054974033e-05 0.000184885842035488 0.970604513867536 0.594059405940594 11.2 11 2 abnormal lens morphology 7.24936785093714e-07 1.84951820812371e-05 0.97009899068323 0.59375 11.2 11 2 increased circulating follicle stimulating hormone level 0.0113474989873017 0.0657969783937368 0.97009899068323 0.59375 11.2 11 2 abnormal heart atrium morphology 0.0113474989873017 0.0657969783937368 0.97009899068323 0.59375 11.2 11 2 kyphosis 8.91527351539852e-08 2.7548748906278e-06 0.969418219461698 0.593333333333333 11.2 11 2 syndactyly 0.000706184710654057 0.00712630615720879 0.969233603537214 0.593220338983051 11.2 11 2 increased circulating triglyceride level 1.49356032890413e-07 4.37086037429297e-06 0.96904262154637 0.593103448275862 11.2 11 2 increased spleen weight 3.43737707841612e-06 7.20985749337428e-05 0.96874347276425 0.592920353982301 11.2 11 2 impaired limb coordination 0.00120943545014104 0.0109598203359775 0.968207959512307 0.592592592592593 11.2 11 2 abnormal bone trabecula morphology 0.0200820627665742 0.100877204196338 0.968207959512307 0.592592592592593 11.2 11 2 male infertility 1.95117444604392e-22 6.06693304316781e-20 0.967967351172468 0.592445328031809 11.2 11 2 hydroencephaly 3.33444942470376e-06 7.02918893555136e-05 0.966103159600324 0.591304347826087 11.2 11 2 abnormal myelopoiesis 0.00358840141433744 0.0264448350972528 0.965457368718238 0.590909090909091 11.2 11 2 decreased blood urea nitrogen level 0.00358840141433744 0.0264448350972528 0.965457368718238 0.590909090909091 11.2 11 2 decreased sensitivity to induced morbidity/mortality 0.00358840141433744 0.0264448350972528 0.965457368718238 0.590909090909091 11.2 11 2 increased body size 0.0360266189142102 0.156808774364126 0.965457368718238 0.590909090909091 11.2 11 2 decreased cardiac output 0.0360266189142102 0.156808774364126 0.965457368718238 0.590909090909091 11.2 11 2 abnormal retinal outer plexiform layer morphology 0.0360266189142102 0.156808774364126 0.965457368718238 0.590909090909091 11.2 11 2 abnormal occipital bone morphology 0.0360266189142102 0.156808774364126 0.965457368718238 0.590909090909091 11.2 11 2 failure of palatal shelf elevation 0.0360266189142102 0.156808774364126 0.965457368718238 0.590909090909091 11.2 11 2 abnormal lipid level 7.90723425756367e-05 0.00112717737625728 0.964562598218963 0.590361445783133 11.2 11 2 reduced fertility 3.94903175117689e-07 1.05625983667231e-05 0.963854506456946 0.589928057553957 11.2 11 2 increased autoantibody level 0.0062276320396135 0.0410908082189352 0.963553113553114 0.58974358974359 11.2 11 2 decreased startle reflex 3.23092526494493e-06 6.83993752897917e-05 0.963553113553114 0.58974358974359 11.2 11 2 alopecia 2.67976867308358e-05 0.000444394971619694 0.963112128146453 0.589473684210526 11.2 11 2 infertility 9.13400845270475e-06 0.000169558552433605 0.961986997155628 0.588785046728972 11.2 11 2 abnormal oocyte morphology 0.0108812013864994 0.0635375315702285 0.961088783339423 0.588235294117647 11.2 11 2 overexpanded pulmonary alveoli 0.0108812013864994 0.0635375315702285 0.961088783339423 0.588235294117647 11.2 11 2 abnormal spleen red pulp morphology 0.0108812013864994 0.0635375315702285 0.961088783339423 0.588235294117647 11.2 11 2 abnormal nervous system development 0.0108812013864994 0.0635375315702285 0.961088783339423 0.588235294117647 11.2 11 2 abnormal bone marrow cavity morphology 0.06594148835151 0.235167673511658 0.961088783339423 0.588235294117647 11.2 11 2 abnormal interatrial septum morphology 0.06594148835151 0.235167673511658 0.961088783339423 0.588235294117647 11.2 11 2 hydroureter 0.06594148835151 0.235167673511658 0.961088783339423 0.588235294117647 11.2 11 2 abnormal melanosome morphology 0.06594148835151 0.235167673511658 0.961088783339423 0.588235294117647 11.2 11 2 coloboma 0.06594148835151 0.235167673511658 0.961088783339423 0.588235294117647 11.2 11 2 delayed heart development 0.06594148835151 0.235167673511658 0.961088783339423 0.588235294117647 11.2 11 2 abnormal locomotor behavior 4.36944902717639e-05 0.000675093444416227 0.95899945989738 0.58695652173913 11.2 11 2 abnormal bone mineralization 3.02377864086582e-06 6.42876014457584e-05 0.958705918587342 0.586776859504132 11.2 11 2 spleen hyperplasia 0.000219208661265445 0.0026861159847182 0.958525879917184 0.586666666666667 11.2 11 2 enlarged heart 1.3384963180949e-10 7.23806432882839e-09 0.957774684086528 0.586206896551724 11.2 11 2 abnormal parietal bone morphology 0.0191798336371872 0.097766057730539 0.957774684086528 0.586206896551724 11.2 11 2 abnormal microglial cell morphology 0.0191798336371872 0.097766057730539 0.957774684086528 0.586206896551724 11.2 11 2 decreased granulocyte number 0.0191798336371872 0.097766057730539 0.957774684086528 0.586206896551724 11.2 11 2 focal hair loss 0.0191798336371872 0.097766057730539 0.957774684086528 0.586206896551724 11.2 11 2 abnormal embryonic erythropoiesis 0.0191798336371872 0.097766057730539 0.957774684086528 0.586206896551724 11.2 11 2 reduced male fertility 2.23176279848241e-10 1.16873893920526e-08 0.957278299176403 0.585903083700441 11.2 11 2 decreased circulating serum albumin level 2.50151551784131e-05 0.000419024905766347 0.957205596336031 0.585858585858586 11.2 11 2 thick epidermis 0.000372182458237402 0.00421778526134641 0.956969831410825 0.585714285714286 11.2 11 2 short ulna 0.00597279635127482 0.0401604186799081 0.956400545371913 0.585365853658537 11.2 11 2 hemopericardium 0.00597279635127482 0.0401604186799081 0.956400545371913 0.585365853658537 11.2 11 2 abnormal rib morphology 1.00373890932012e-06 2.44784366366058e-05 0.956105360018403 0.585185185185185 11.2 11 2 cleft secondary palate 4.21582796164786e-05 0.000655429503412441 0.955976608959958 0.585106382978723 11.2 11 2 abnormal coat/ hair morphology 0.00192477475812255 0.0162196808104765 0.955648658150709 0.584905660377358 11.2 11 2 neonatal lethality, incomplete penetrance 1.51576279119557e-11 9.54546821037718e-10 0.955174390826565 0.584615384615385 11.2 11 2 abnormal muscle physiology 7.11240152333126e-05 0.00103160925885053 0.954609533114663 0.584269662921348 11.2 11 2 arrest of spermatogenesis 0.000120131851650864 0.00161528638368391 0.953079710144928 0.583333333333333 11.2 11 2 short radius 0.0104034488180736 0.0610343842805613 0.953079710144928 0.583333333333333 11.2 11 2 abnormal digestive system morphology 0.0342115951479795 0.149562992848153 0.953079710144928 0.583333333333333 11.2 11 2 abnormal nursing 0.0342115951479795 0.149562992848153 0.953079710144928 0.583333333333333 11.2 11 2 abnormal startle reflex 0.0342115951479795 0.149562992848153 0.953079710144928 0.583333333333333 11.2 11 2 abnormal cardiac muscle contractility 0.0342115951479795 0.149562992848153 0.953079710144928 0.583333333333333 11.2 11 2 abnormal osteoblast morphology 0.0342115951479795 0.149562992848153 0.953079710144928 0.583333333333333 11.2 11 2 abnormal superior cervical ganglion morphology 0.124718690618355 0.376045748985646 0.953079710144928 0.583333333333333 11.2 11 2 abnormal enteric nervous system morphology 0.124718690618355 0.376045748985646 0.953079710144928 0.583333333333333 11.2 11 2 absent optic nerve 0.124718690618355 0.376045748985646 0.953079710144928 0.583333333333333 11.2 11 2 altered tumor susceptibility 0.124718690618355 0.376045748985646 0.953079710144928 0.583333333333333 11.2 11 2 decreased synaptic depression 0.124718690618355 0.376045748985646 0.953079710144928 0.583333333333333 11.2 11 2 abnormal aorta elastic fiber morphology 0.124718690618355 0.376045748985646 0.953079710144928 0.583333333333333 11.2 11 2 abnormal alisphenoid bone morphology 0.124718690618355 0.376045748985646 0.953079710144928 0.583333333333333 11.2 11 2 loss of dopaminergic neurons 0.124718690618355 0.376045748985646 0.953079710144928 0.583333333333333 11.2 11 2 abnormal defecation 0.124718690618355 0.376045748985646 0.953079710144928 0.583333333333333 11.2 11 2 abnormal B cell proliferation 0.124718690618355 0.376045748985646 0.953079710144928 0.583333333333333 11.2 11 2 decreased prostaglandin level 0.124718690618355 0.376045748985646 0.953079710144928 0.583333333333333 11.2 11 2 decreased mammary gland epithelial cell proliferation 0.124718690618355 0.376045748985646 0.953079710144928 0.583333333333333 11.2 11 2 abnormal vitelline vein connection 0.124718690618355 0.376045748985646 0.953079710144928 0.583333333333333 11.2 11 2 muscular ventricular septal defect 0.00107982289671829 0.0100601477737331 0.953079710144927 0.583333333333333 11.2 11 2 female infertility 1.36504932002548e-11 8.70656457323944e-10 0.952055994022323 0.582706766917293 11.2 11 2 hunched posture 0.000203176046093167 0.00251279027542924 0.951356238698011 0.582278481012658 11.2 11 2 maternal effect 0.000608491295400117 0.00634642388808298 0.951047557244832 0.582089552238806 11.2 11 2 absent mature ovarian follicles 0.0182621202057802 0.093942764529764 0.948687637747946 0.580645161290323 11.2 11 2 abnormal retinal photoreceptor layer morphology 0.0182621202057802 0.093942764529764 0.948687637747946 0.580645161290323 11.2 11 2 abnormal spleen morphology 5.9711702224632e-08 1.92188901417201e-06 0.948384736203327 0.580459770114943 11.2 11 2 decreased respiratory quotient 0.00316811651944841 0.0237370175967709 0.947633540372671 0.58 11.2 11 2 abnormal sternum morphology 0.000583892604043437 0.00610265904436155 0.947159960392475 0.579710144927536 11.2 11 2 hyperkeratosis 0.000583892604043437 0.00610265904436155 0.947159960392475 0.579710144927536 11.2 11 2 ataxia 6.65834563412496e-09 2.54809765613628e-07 0.946339401020847 0.579207920792079 11.2 11 2 increased macrophage cell number 0.00176851991392745 0.0150143115559541 0.945913697286695 0.578947368421053 11.2 11 2 abnormal retinal outer nuclear layer morphology 0.00992232408012886 0.0594026020440927 0.945913697286695 0.578947368421053 11.2 11 2 small superior vagus ganglion 0.0620689709940981 0.22279446659137 0.945913697286695 0.578947368421053 11.2 11 2 abnormal stationary movement 0.0620689709940981 0.22279446659137 0.945913697286695 0.578947368421053 11.2 11 2 decreased tumor incidence 0.0620689709940981 0.22279446659137 0.945913697286695 0.578947368421053 11.2 11 2 osteoarthritis 0.0620689709940981 0.22279446659137 0.945913697286695 0.578947368421053 11.2 11 2 increased left ventricle weight 0.0620689709940981 0.22279446659137 0.945913697286695 0.578947368421053 11.2 11 2 abnormal sternebra morphology 0.0620689709940981 0.22279446659137 0.945913697286695 0.578947368421053 11.2 11 2 decreased circulating magnesium level 0.0620689709940981 0.22279446659137 0.945913697286695 0.578947368421053 11.2 11 2 decreased liver glycogen level 0.0620689709940981 0.22279446659137 0.945913697286695 0.578947368421053 11.2 11 2 thin interventricular septum 0.0620689709940981 0.22279446659137 0.945913697286695 0.578947368421053 11.2 11 2 decreased lymphocyte cell number 4.05618756246375e-06 8.37325025861293e-05 0.944570069875776 0.578125 11.2 11 2 abnormal osteoclast physiology 0.000992601737312311 0.00938029098741372 0.944570069875776 0.578125 11.2 11 2 abnormal tooth morphology 0.000992601737312311 0.00938029098741372 0.944570069875776 0.578125 11.2 11 2 abnormal female meiosis 0.00302764090410282 0.0227187232246026 0.942606306736742 0.576923076923077 11.2 11 2 increased leukemia incidence 0.032388752774728 0.142596500048028 0.942606306736742 0.576923076923077 11.2 11 2 abnormal nerve conduction 0.032388752774728 0.142596500048028 0.942606306736742 0.576923076923077 11.2 11 2 abnormal vascular development 0.000949666525517816 0.00908575185471372 0.940702051571617 0.575757575757576 11.2 11 2 abnormal tooth development 0.0173454324641994 0.0907397755093504 0.940702051571617 0.575757575757576 11.2 11 2 dextrocardia 0.0173454324641994 0.0907397755093504 0.940702051571617 0.575757575757576 11.2 11 2 abnormal epidermis stratum basale morphology 0.0173454324641994 0.0907397755093504 0.940702051571617 0.575757575757576 11.2 11 2 decreased systemic arterial blood pressure 0.0173454324641994 0.0907397755093504 0.940702051571617 0.575757575757576 11.2 11 2 dilated heart atrium 0.0173454324641994 0.0907397755093504 0.940702051571617 0.575757575757576 11.2 11 2 cardiovascular system phenotype 0.0173454324641994 0.0907397755093504 0.940702051571617 0.575757575757576 11.2 11 2 myeloid hyperplasia 0.0173454324641994 0.0907397755093504 0.940702051571617 0.575757575757576 11.2 11 2 increased circulating insulin level 4.09655690842638e-07 1.0898593914129e-05 0.939464285714286 0.575 11.2 11 2 abnormal posture 0.000303072688144249 0.00353111621432703 0.939464285714286 0.575 11.2 11 2 impaired ovarian folliculogenesis 0.00944395656290754 0.0566068480728494 0.939464285714286 0.575 11.2 11 2 abnormal skin pigmentation 0.00944395656290754 0.0566068480728494 0.939464285714286 0.575 11.2 11 2 increased susceptibility to weight loss 0.00944395656290754 0.0566068480728494 0.939464285714286 0.575 11.2 11 2 abnormal tibia morphology 0.00520128297318937 0.0357408602094159 0.938595216069777 0.574468085106383 11.2 11 2 polyphagia 0.00288892773844542 0.02211140845964 0.937951460777548 0.574074074074074 11.2 11 2 decreased platelet aggregation 0.00288892773844542 0.02211140845964 0.937951460777548 0.574074074074074 11.2 11 2 abnormal long bone morphology 0.00161500668841567 0.0139490595049791 0.937455452601568 0.573770491803279 11.2 11 2 increased double-negative T cell number 0.00161500668841567 0.0139490595049791 0.937455452601568 0.573770491803279 11.2 11 2 increased startle reflex 0.000164577633999657 0.00211569439056406 0.936251657477842 0.573033707865168 11.2 11 2 increased sensitivity to xenobiotic induced morbidity/mortality 3.05162589561092e-05 0.000493978208106856 0.935750988142293 0.572727272727273 11.2 11 2 decreased neutrophil cell number 1.74606201008225e-05 0.000304795035093305 0.935624037797951 0.572649572649573 11.2 11 2 impaired coordination 2.44054250033861e-13 1.95833853857816e-11 0.934978278820953 0.572254335260116 11.2 11 2 limb grasping 1.14983212425949e-07 3.48805781597009e-06 0.933629103815439 0.571428571428571 11.2 11 2 small ovary 0.000157326296083957 0.00204894848957509 0.933629103815439 0.571428571428571 11.2 11 2 increased body weight 4.26172549465024e-09 1.72374669397439e-07 0.933629103815439 0.571428571428571 11.2 11 2 abnormal cardiovascular system physiology 5.49366330766752e-06 0.000106761620920492 0.933629103815439 0.571428571428571 11.2 11 2 cardiac hypertrophy 8.95687281569297e-05 0.00124470509100761 0.933629103815439 0.571428571428571 11.2 11 2 increased food intake 0.000276988007696427 0.00332051888744512 0.933629103815439 0.571428571428571 11.2 11 2 short mandible 0.00275279343466592 0.0211350723517915 0.933629103815439 0.571428571428571 11.2 11 2 abnormal long bone hypertrophic chondrocyte zone 0.0049500870959743 0.0341562875207658 0.933629103815439 0.571428571428571 11.2 11 2 increased fluid intake 0.0049500870959743 0.0341562875207658 0.933629103815439 0.571428571428571 11.2 11 2 impaired adaptive thermogenesis 0.016441622710922 0.0868334108140518 0.933629103815439 0.571428571428571 11.2 11 2 rib bifurcation 0.0305913268798741 0.138734595467068 0.933629103815439 0.571428571428571 11.2 11 2 small superior cervical ganglion 0.0305913268798741 0.138734595467068 0.933629103815439 0.571428571428571 11.2 11 2 abnormal ovulation 0.0305913268798741 0.138734595467068 0.933629103815439 0.571428571428571 11.2 11 2 absent corpus callosum 0.0305913268798741 0.138734595467068 0.933629103815439 0.571428571428571 11.2 11 2 increased bone resorption 0.0305913268798741 0.138734595467068 0.933629103815439 0.571428571428571 11.2 11 2 corneal vascularization 0.0305913268798741 0.138734595467068 0.933629103815439 0.571428571428571 11.2 11 2 abnormal associative learning 0.0582681651306671 0.210671599945544 0.933629103815439 0.571428571428571 11.2 11 2 abnormal bile salt homeostasis 0.0582681651306671 0.210671599945544 0.933629103815439 0.571428571428571 11.2 11 2 increased keratinocyte proliferation 0.0582681651306671 0.210671599945544 0.933629103815439 0.571428571428571 11.2 11 2 translucent skin 0.115608761976834 0.354595308776048 0.933629103815439 0.571428571428571 11.2 11 2 abnormal placing response 0.115608761976834 0.354595308776048 0.933629103815439 0.571428571428571 11.2 11 2 extended life span 0.115608761976834 0.354595308776048 0.933629103815439 0.571428571428571 11.2 11 2 absent visceral yolk sac blood islands 0.115608761976834 0.354595308776048 0.933629103815439 0.571428571428571 11.2 11 2 decreased vascular permeability 0.115608761976834 0.354595308776048 0.933629103815439 0.571428571428571 11.2 11 2 intestinal obstruction 0.115608761976834 0.354595308776048 0.933629103815439 0.571428571428571 11.2 11 2 abnormal uterus development 0.115608761976834 0.354595308776048 0.933629103815439 0.571428571428571 11.2 11 2 abnormal squamosal bone morphology 0.115608761976834 0.354595308776048 0.933629103815439 0.571428571428571 11.2 11 2 decreased CNS synapse formation 0.115608761976834 0.354595308776048 0.933629103815439 0.571428571428571 11.2 11 2 abnormal iris pigmentation 0.115608761976834 0.354595308776048 0.933629103815439 0.571428571428571 11.2 11 2 premature hair loss 0.115608761976834 0.354595308776048 0.933629103815439 0.571428571428571 11.2 11 2 increased pulmonary respiratory rate 0.115608761976834 0.354595308776048 0.933629103815439 0.571428571428571 11.2 11 2 decreased response to antigen 0.115608761976834 0.354595308776048 0.933629103815439 0.571428571428571 11.2 11 2 decreased double-positive T cell number 8.55861021703634e-05 0.00119941086844383 0.931295031055901 0.57 11.2 11 2 respiratory failure 1.66039372464976e-06 3.75475399096935e-05 0.930537616716713 0.56953642384106 11.2 11 2 increased lung adenocarcinoma incidence 0.00470468558619782 0.0325532834371824 0.929052490561442 0.568627450980392 11.2 11 2 abnormal dendritic spine morphology 0.00470468558619782 0.0325532834371824 0.929052490561442 0.568627450980392 11.2 11 2 increased liver weight 0.000252256110976979 0.0030313385316678 0.928324392998306 0.568181818181818 11.2 11 2 teratozoospermia 0.000252256110976979 0.0030313385316678 0.928324392998306 0.568181818181818 11.2 11 2 muscular atrophy 0.00851272559071981 0.0514836815501993 0.928324392998306 0.568181818181818 11.2 11 2 abnormal skeleton development 0.00044482077259852 0.00492869341576311 0.927865961199295 0.567901234567901 11.2 11 2 increased granulocyte number 0.000786777799909115 0.00772035415098194 0.927320799059929 0.567567567567568 11.2 11 2 increased brown adipose tissue amount 0.0155590957016184 0.0823473416122889 0.927320799059929 0.567567567567568 11.2 11 2 abnormal branching of the mammary ductal tree 0.0155590957016184 0.0823473416122889 0.927320799059929 0.567567567567568 11.2 11 2 abnormal breathing pattern 0.0155590957016184 0.0823473416122889 0.927320799059929 0.567567567567568 11.2 11 2 abnormal hair follicle development 0.0155590957016184 0.0823473416122889 0.927320799059929 0.567567567567568 11.2 11 2 increased trabecular bone volume 0.0155590957016184 0.0823473416122889 0.927320799059929 0.567567567567568 11.2 11 2 postnatal lethality, complete penetrance 4.63060348733507e-14 4.43024083644077e-12 0.926977601132816 0.567357512953368 11.2 11 2 cachexia 7.79778590572018e-05 0.0011147696804873 0.926896201624462 0.567307692307692 11.2 11 2 intracranial hemorrhage 0.00249064836161321 0.0194520810031801 0.925848861283644 0.566666666666667 11.2 11 2 enhanced paired-pulse facilitation 0.0288411769783738 0.131516824443089 0.925848861283644 0.566666666666667 11.2 11 2 hyperactivity 2.08593754445655e-13 1.72958988061189e-11 0.924821282081331 0.566037735849057 11.2 11 2 deafness 0.000130368787344671 0.00174350730387026 0.924198506807203 0.565656565656566 11.2 11 2 abnormal coat appearance 0.00132811781872178 0.0118200109984631 0.923480961382663 0.565217391304348 11.2 11 2 fragile skeleton 0.0545992481623198 0.198862688819956 0.923480961382663 0.565217391304348 11.2 11 2 abnormal cranial nerve morphology 0.0545992481623198 0.198862688819956 0.923480961382663 0.565217391304348 11.2 11 2 hypotension 0.0545992481623198 0.198862688819956 0.923480961382663 0.565217391304348 11.2 11 2 pancreas inflammation 0.0545992481623198 0.198862688819956 0.923480961382663 0.565217391304348 11.2 11 2 abnormal cardiovascular development 0.0545992481623198 0.198862688819956 0.923480961382663 0.565217391304348 11.2 11 2 decreased epididymis weight 0.0545992481623198 0.198862688819956 0.923480961382663 0.565217391304348 11.2 11 2 abnormal palatal shelf fusion at midline 0.0545992481623198 0.198862688819956 0.923480961382663 0.565217391304348 11.2 11 2 cardiac fibrosis 0.000403314790376324 0.0045498663993701 0.922645232005846 0.564705882352941 11.2 11 2 abnormal lens fiber morphology 0.0147036902502076 0.0784039217521787 0.92165949992037 0.564102564102564 11.2 11 2 abnormal circulating hormone level 0.0147036902502076 0.0784039217521787 0.92165949992037 0.564102564102564 11.2 11 2 decreased circulating calcium level 0.00423530460731394 0.0296062900972343 0.92089779785432 0.563636363636364 11.2 11 2 abnormal gait 4.09560028283511e-11 2.41786452720062e-09 0.920032563468613 0.563106796116505 11.2 11 2 decreased B cell number 6.66675468586199e-08 2.09918383304832e-06 0.920032563468612 0.563106796116505 11.2 11 2 retinal degeneration 0.000207394449233499 0.00255392917063528 0.919041149068323 0.5625 11.2 11 2 decreased caudal vertebrae number 0.00224462115444675 0.0184273766392287 0.919041149068323 0.5625 11.2 11 2 curly tail 0.00763380755166843 0.048134591342903 0.919041149068323 0.5625 11.2 11 2 abnormal lymphatic vessel morphology 0.0271523474866811 0.124043093430889 0.919041149068323 0.5625 11.2 11 2 neonatal lethality 0.0271523474866811 0.124043093430889 0.919041149068323 0.5625 11.2 11 2 failure of tooth eruption 0.107058780972921 0.332470309201174 0.919041149068323 0.5625 11.2 11 2 abnormal mouth morphology 0.107058780972921 0.332470309201174 0.919041149068323 0.5625 11.2 11 2 disorganized retinal layers 0.107058780972921 0.332470309201174 0.919041149068323 0.5625 11.2 11 2 abnormal intestinal absorption 0.107058780972921 0.332470309201174 0.919041149068323 0.5625 11.2 11 2 white spotting 0.107058780972921 0.332470309201174 0.919041149068323 0.5625 11.2 11 2 abnormal epicardium morphology 0.107058780972921 0.332470309201174 0.919041149068323 0.5625 11.2 11 2 increased pancreatic beta cell number 0.107058780972921 0.332470309201174 0.919041149068323 0.5625 11.2 11 2 abnormal amnion morphology 0.107058780972921 0.332470309201174 0.919041149068323 0.5625 11.2 11 2 abnormal level of surface class II molecules 0.107058780972921 0.332470309201174 0.919041149068323 0.5625 11.2 11 2 abnormal intestinal lipid absorption 0.107058780972921 0.332470309201174 0.919041149068323 0.5625 11.2 11 2 decreased skeletal muscle weight 0.107058780972921 0.332470309201174 0.919041149068323 0.5625 11.2 11 2 decreased midbrain size 0.107058780972921 0.332470309201174 0.919041149068323 0.5625 11.2 11 2 increased circulating HDL cholesterol level 0.000112457820941221 0.00151619961838097 0.918068618751849 0.561904761904762 11.2 11 2 neonatal lethality, complete penetrance 1.9449533098527e-15 2.52719990409918e-13 0.917249645853765 0.56140350877193 11.2 11 2 sparse hair 0.000642807576048992 0.00668418510587687 0.916550522648084 0.560975609756098 11.2 11 2 scaly skin 0.0138793279444382 0.0755085939650392 0.916550522648084 0.560975609756098 11.2 11 2 lethality at weaning, incomplete penetrance 0.0138793279444382 0.0755085939650392 0.916550522648084 0.560975609756098 11.2 11 2 respiratory distress 9.9031771284493e-07 2.42701015832686e-05 0.916089828743762 0.560693641618497 11.2 11 2 abnormal skin morphology 0.00212824338550152 0.0177485748439069 0.915946734424995 0.560606060606061 11.2 11 2 abnormal locomotor activation 0.000346430832697863 0.00394392080702945 0.915674697972835 0.56043956043956 11.2 11 2 postnatal lethality 1.71725960272213e-06 3.83110606436888e-05 0.915350220758812 0.560240963855422 11.2 11 2 abnormal neurocranium morphology 0.00113647580663306 0.0103363201791581 0.91495652173913 0.56 11.2 11 2 increased monocyte cell number 0.00018736493211197 0.00234796105102532 0.91495652173913 0.56 11.2 11 2 decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 0.0510951305517133 0.198862688819956 0.91495652173913 0.56 11.2 11 2 decreased T cell number 2.83444264579703e-06 6.05208247332198e-05 0.913332818949886 0.559006211180124 11.2 11 2 abnormal endoderm development 0.0255334584959527 0.117077378817847 0.913034344172452 0.558823529411765 11.2 11 2 increased susceptibility to weight gain 0.0255334584959527 0.117077378817847 0.913034344172452 0.558823529411765 11.2 11 2 increased inflammatory response 0.000312139473274039 0.00362825672789333 0.911516835567179 0.557894736842105 11.2 11 2 abnormal snout morphology 0.00681922018536104 0.044173984924702 0.911186096512183 0.557692307692308 11.2 11 2 abnormal skin condition 0.00681922018536104 0.044173984924702 0.911186096512183 0.557692307692308 11.2 11 2 abnormal maternal nurturing 0.00359330824638047 0.0264448350972528 0.910671011098666 0.557377049180328 11.2 11 2 increased osteoclast cell number 0.00359330824638047 0.0264448350972528 0.910671011098666 0.557377049180328 11.2 11 2 abnormal skeleton morphology 8.70145332395844e-05 0.00121600365973857 0.909273561976776 0.556521739130435 11.2 11 2 improved glucose tolerance 3.8325017327599e-07 1.03623348480872e-05 0.908621181391811 0.556122448979592 11.2 11 2 abnormal mandible morphology 0.00643770474611675 0.0423645252803318 0.907694962042788 0.555555555555556 11.2 11 2 axon degeneration 0.00643770474611675 0.0423645252803318 0.907694962042788 0.555555555555556 11.2 11 2 rectal prolapse 0.0477721152849204 0.186697779687729 0.907694962042788 0.555555555555556 11.2 11 2 cryptorchism 0.0477721152849204 0.186697779687729 0.907694962042788 0.555555555555556 11.2 11 2 abnormal skin appearance 0.0477721152849204 0.186697779687729 0.907694962042788 0.555555555555556 11.2 11 2 decreased heart weight 0.000966867316359681 0.00923256218596816 0.907694962042788 0.555555555555556 11.2 11 2 abnormal neuromuscular synapse morphology 0.00180672416870723 0.0152864842505416 0.907694962042788 0.555555555555556 11.2 11 2 abnormal ovarian follicle morphology 0.0123326014691303 0.0698779089905028 0.907694962042788 0.555555555555556 11.2 11 2 cardiomyopathy 0.0123326014691303 0.0698779089905028 0.907694962042788 0.555555555555556 11.2 11 2 abnormal limb bone morphology 0.0239893400769825 0.110263055188876 0.907694962042788 0.555555555555556 11.2 11 2 underdeveloped hair follicles 0.099108501971902 0.310298802586666 0.907694962042788 0.555555555555556 11.2 11 2 abnormal retinal rod cell morphology 0.099108501971902 0.310298802586666 0.907694962042788 0.555555555555556 11.2 11 2 abnormal Peyer's patch follicle morphology 0.099108501971902 0.310298802586666 0.907694962042788 0.555555555555556 11.2 11 2 acidosis 0.099108501971902 0.310298802586666 0.907694962042788 0.555555555555556 11.2 11 2 decreased activity of thyroid 0.099108501971902 0.310298802586666 0.907694962042788 0.555555555555556 11.2 11 2 abnormal neutrophil morphology 0.099108501971902 0.310298802586666 0.907694962042788 0.555555555555556 11.2 11 2 jerky movement 0.099108501971902 0.310298802586666 0.907694962042788 0.555555555555556 11.2 11 2 decreased fluid intake 0.099108501971902 0.310298802586666 0.907694962042788 0.555555555555556 11.2 11 2 crypts of Lieberkuhn abscesses 0.225560306548371 0.511235774523074 0.907694962042788 0.555555555555556 11.2 11 2 absent parathyroid glands 0.225560306548371 0.511235774523074 0.907694962042788 0.555555555555556 11.2 11 2 small geniculate ganglion 0.225560306548371 0.511235774523074 0.907694962042788 0.555555555555556 11.2 11 2 abnormal kindling response 0.225560306548371 0.511235774523074 0.907694962042788 0.555555555555556 11.2 11 2 multifocal hepatic necrosis 0.225560306548371 0.511235774523074 0.907694962042788 0.555555555555556 11.2 11 2 decreased level of surface class I molecules 0.225560306548371 0.511235774523074 0.907694962042788 0.555555555555556 11.2 11 2 abnormal taste sensitivity 0.225560306548371 0.511235774523074 0.907694962042788 0.555555555555556 11.2 11 2 abnormal thymus lobule morphology 0.225560306548371 0.511235774523074 0.907694962042788 0.555555555555556 11.2 11 2 abnormal NMDA-mediated synaptic currents 0.225560306548371 0.511235774523074 0.907694962042788 0.555555555555556 11.2 11 2 genetic imprinting 0.225560306548371 0.511235774523074 0.907694962042788 0.555555555555556 11.2 11 2 abnormal lens capsule morphology 0.225560306548371 0.511235774523074 0.907694962042788 0.555555555555556 11.2 11 2 abnormal abdominal wall morphology 0.225560306548371 0.511235774523074 0.907694962042788 0.555555555555556 11.2 11 2 priapism 0.225560306548371 0.511235774523074 0.907694962042788 0.555555555555556 11.2 11 2 premature bone ossification 0.225560306548371 0.511235774523074 0.907694962042788 0.555555555555556 11.2 11 2 abnormal ovary physiology 0.225560306548371 0.511235774523074 0.907694962042788 0.555555555555556 11.2 11 2 decreased cellular sensitivity to ionizing radiation 0.225560306548371 0.511235774523074 0.907694962042788 0.555555555555556 11.2 11 2 abnormal optic chiasm morphology 0.225560306548371 0.511235774523074 0.907694962042788 0.555555555555556 11.2 11 2 multiflagellated sperm 0.225560306548371 0.511235774523074 0.907694962042788 0.555555555555556 11.2 11 2 abnormal hyoid bone lesser horn morphology 0.225560306548371 0.511235774523074 0.907694962042788 0.555555555555556 11.2 11 2 abnormal telomere morphology 0.225560306548371 0.511235774523074 0.907694962042788 0.555555555555556 11.2 11 2 retropulsion 0.225560306548371 0.511235774523074 0.907694962042788 0.555555555555556 11.2 11 2 abnormal ventricle myocardium morphology 0.225560306548371 0.511235774523074 0.907694962042788 0.555555555555556 11.2 11 2 shortened ST segment 0.225560306548371 0.511235774523074 0.907694962042788 0.555555555555556 11.2 11 2 decreased airway resistance 0.225560306548371 0.511235774523074 0.907694962042788 0.555555555555556 11.2 11 2 abnormal ureteric bud invasion 0.225560306548371 0.511235774523074 0.907694962042788 0.555555555555556 11.2 11 2 decreased bone trabecular spacing 0.225560306548371 0.511235774523074 0.907694962042788 0.555555555555556 11.2 11 2 increased myeloid cell number 0.225560306548371 0.511235774523074 0.907694962042788 0.555555555555556 11.2 11 2 trigeminal neuroma 0.225560306548371 0.511235774523074 0.907694962042788 0.555555555555556 11.2 11 2 abnormal ductus venosus valve topology 0.225560306548371 0.511235774523074 0.907694962042788 0.555555555555556 11.2 11 2 abnormal coronary sinus connection 0.225560306548371 0.511235774523074 0.907694962042788 0.555555555555556 11.2 11 2 cerebellum atrophy 0.225560306548371 0.511235774523074 0.907694962042788 0.555555555555556 11.2 11 2 decreased bone mineral density of femur 0.225560306548371 0.511235774523074 0.907694962042788 0.555555555555556 11.2 11 2 increased bone mineralization 0.225560306548371 0.511235774523074 0.907694962042788 0.555555555555556 11.2 11 2 increased endoplasmic reticulum stress 0.225560306548371 0.511235774523074 0.907694962042788 0.555555555555556 11.2 11 2 decreased platelet dense granule number 0.225560306548371 0.511235774523074 0.907694962042788 0.555555555555556 11.2 11 2 abnormal spatial learning 5.62999016343225e-06 0.000108985218144262 0.902126281294059 0.552147239263804 11.2 11 2 abnormal spermiogenesis 0.00572686792539727 0.0392440329598504 0.901434996787321 0.551724137931034 11.2 11 2 decreased retinal photoreceptor cell number 0.0446362416401039 0.175130364479114 0.901434996787321 0.551724137931034 11.2 11 2 organ of Corti degeneration 0.0109274644745658 0.0636582385959774 0.900285207250602 0.551020408163265 11.2 11 2 abnormal epidermis stratum corneum morphology 0.0109274644745658 0.0636582385959774 0.900285207250602 0.551020408163265 11.2 11 2 no abnormal phenotype detected 5.8466148661445e-50 5.81738179181378e-47 0.900265988866415 0.551008645533141 11.2 11 2 abnormal pancreatic beta cell morphology 0.0211322536457966 0.10167597861493 0.89861801242236 0.55 11.2 11 2 abnormal basioccipital bone morphology 0.0917508484949661 0.289632278719833 0.89861801242236 0.55 11.2 11 2 anencephaly 0.0917508484949661 0.289632278719833 0.89861801242236 0.55 11.2 11 2 abnormal hair texture 0.0917508484949661 0.289632278719833 0.89861801242236 0.55 11.2 11 2 abnormal fibula morphology 0.0917508484949661 0.289632278719833 0.89861801242236 0.55 11.2 11 2 abnormal optic stalk morphology 0.0917508484949661 0.289632278719833 0.89861801242236 0.55 11.2 11 2 abnormal heart electrocardiography waveform feature 0.0917508484949661 0.289632278719833 0.89861801242236 0.55 11.2 11 2 decreased muscle cell glucose uptake 0.0917508484949661 0.289632278719833 0.89861801242236 0.55 11.2 11 2 increased thermal nociceptive threshold 0.000731522055705982 0.00735216611542881 0.89772029213023 0.549450549450549 11.2 11 2 abnormal object recognition memory 0.0416871744879519 0.165032564239577 0.895982768984171 0.548387096774194 11.2 11 2 autoimmune response 0.0416871744879519 0.165032564239577 0.895982768984171 0.548387096774194 11.2 11 2 decreased neuronal precursor cell number 0.0416871744879519 0.165032564239577 0.895982768984171 0.548387096774194 11.2 11 2 decreased double-negative T cell number 0.0416871744879519 0.165032564239577 0.895982768984171 0.548387096774194 11.2 11 2 decreased susceptibility to bacterial infection induced morbidity/mortality 0.0416871744879519 0.165032564239577 0.895982768984171 0.548387096774194 11.2 11 2 abnormal intestine physiology 0.0416871744879519 0.165032564239577 0.895982768984171 0.548387096774194 11.2 11 2 skin edema 0.0198186250386038 0.100712624685449 0.894727891156463 0.547619047619048 11.2 11 2 abnormal vibrissa morphology 0.0198186250386038 0.100712624685449 0.894727891156463 0.547619047619048 11.2 11 2 increased T cell number 0.00114308598990611 0.0103774686127426 0.891191417278374 0.545454545454545 11.2 11 2 obese 0.00226067953786851 0.0185286337741282 0.891191417278374 0.545454545454545 11.2 11 2 abnormal joint morphology 0.00908058491268016 0.0546262514396418 0.891191417278374 0.545454545454545 11.2 11 2 abnormal circadian rhythm 0.018579417778068 0.0951932064324285 0.891191417278374 0.545454545454545 11.2 11 2 abnormal ovarian folliculogenesis 0.0389206455136591 0.162642205394726 0.891191417278374 0.545454545454545 11.2 11 2 abnormal skeleton physiology 0.0389206455136591 0.162642205394726 0.891191417278374 0.545454545454545 11.2 11 2 abnormal abdominal fat pad morphology 0.0849580205904151 0.270246900535368 0.891191417278374 0.545454545454545 11.2 11 2 abnormal cochlear sensory epithelium morphology 0.0849580205904151 0.270246900535368 0.891191417278374 0.545454545454545 11.2 11 2 abnormal limb posture 0.0849580205904151 0.270246900535368 0.891191417278374 0.545454545454545 11.2 11 2 abnormal basement membrane morphology 0.0849580205904151 0.270246900535368 0.891191417278374 0.545454545454545 11.2 11 2 decreased circulating estradiol level 0.0849580205904151 0.270246900535368 0.891191417278374 0.545454545454545 11.2 11 2 abnormal sperm midpiece morphology 0.0849580205904151 0.270246900535368 0.891191417278374 0.545454545454545 11.2 11 2 abnormal cerebral cortex pyramidal cell morphology 0.0849580205904151 0.270246900535368 0.891191417278374 0.545454545454545 11.2 11 2 pulmonary vascular congestion 0.0849580205904151 0.270246900535368 0.891191417278374 0.545454545454545 11.2 11 2 increased circulating creatine kinase level 0.0849580205904151 0.270246900535368 0.891191417278374 0.545454545454545 11.2 11 2 rough coat 0.0849580205904151 0.270246900535368 0.891191417278374 0.545454545454545 11.2 11 2 increased mammary gland tumor incidence 0.0849580205904151 0.270246900535368 0.891191417278374 0.545454545454545 11.2 11 2 increased bone volume 0.0849580205904151 0.270246900535368 0.891191417278374 0.545454545454545 11.2 11 2 premature suture closure 0.203577796006512 0.47172777602813 0.891191417278374 0.545454545454545 11.2 11 2 abnormal awl hair morphology 0.203577796006512 0.47172777602813 0.891191417278374 0.545454545454545 11.2 11 2 abnormal glossopharyngeal ganglion morphology 0.203577796006512 0.47172777602813 0.891191417278374 0.545454545454545 11.2 11 2 failure of somite differentiation 0.203577796006512 0.47172777602813 0.891191417278374 0.545454545454545 11.2 11 2 abnormal primary sex determination 0.203577796006512 0.47172777602813 0.891191417278374 0.545454545454545 11.2 11 2 abnormal larynx morphology 0.203577796006512 0.47172777602813 0.891191417278374 0.545454545454545 11.2 11 2 abnormal bronchiole morphology 0.203577796006512 0.47172777602813 0.891191417278374 0.545454545454545 11.2 11 2 abnormal nerve fiber response 0.203577796006512 0.47172777602813 0.891191417278374 0.545454545454545 11.2 11 2 abnormal spinal cord ventral horn morphology 0.203577796006512 0.47172777602813 0.891191417278374 0.545454545454545 11.2 11 2 abnormal superovulation 0.203577796006512 0.47172777602813 0.891191417278374 0.545454545454545 11.2 11 2 decreased palatine bone horizontal plate size 0.203577796006512 0.47172777602813 0.891191417278374 0.545454545454545 11.2 11 2 shortened PR interval 0.203577796006512 0.47172777602813 0.891191417278374 0.545454545454545 11.2 11 2 abnormal extraembryonic ectoderm morphology 0.203577796006512 0.47172777602813 0.891191417278374 0.545454545454545 11.2 11 2 decreased core body temperature 0.203577796006512 0.47172777602813 0.891191417278374 0.545454545454545 11.2 11 2 abnormal phrenic nerve innervation pattern to diaphragm 0.203577796006512 0.47172777602813 0.891191417278374 0.545454545454545 11.2 11 2 thin hypoglossal nerve 0.203577796006512 0.47172777602813 0.891191417278374 0.545454545454545 11.2 11 2 decreased B cell proliferation 0.00212982898126883 0.0177485748439069 0.88931126660901 0.544303797468354 11.2 11 2 abnormal sleep pattern 0.0174121748121433 0.090993245473123 0.887962462867945 0.543478260869565 11.2 11 2 weight loss 8.1925364490799e-06 0.00015322507080516 0.886947648624667 0.542857142857143 11.2 11 2 increased carcinoma incidence 0.0363300134906767 0.157991098877724 0.886947648624667 0.542857142857143 11.2 11 2 abnormal colon morphology 0.00801222630878174 0.049029306133074 0.886156437519739 0.542372881355932 11.2 11 2 abnormal thoracic vertebrae morphology 0.00801222630878174 0.049029306133074 0.886156437519739 0.542372881355932 11.2 11 2 decreased metastatic potential 0.0786937471792671 0.252744604400809 0.885002587991718 0.541666666666667 11.2 11 2 curly vibrissae 0.0786937471792671 0.252744604400809 0.885002587991718 0.541666666666667 11.2 11 2 abnormal retinal ganglion layer morphology 0.0786937471792671 0.252744604400809 0.885002587991718 0.541666666666667 11.2 11 2 abnormal truncus arteriosus septation 0.0786937471792671 0.252744604400809 0.885002587991718 0.541666666666667 11.2 11 2 circling 0.00177826462606375 0.0150713228529253 0.884201680672269 0.541176470588235 11.2 11 2 abnormal vocalization 0.0339072746362343 0.148886753146748 0.883162665771361 0.540540540540541 11.2 11 2 increased body length 0.0152819949232411 0.0813132884953205 0.88227950310559 0.54 11.2 11 2 abnormal nervous system physiology 0.00036327206717828 0.00412620669911402 0.880858763165001 0.539130434782609 11.2 11 2 increased circulating glucose level 8.54503109456435e-05 0.00119941086844383 0.880657239769173 0.539007092198582 11.2 11 2 abnormal heart looping 0.0316437221857804 0.142596500048028 0.879765886287626 0.538461538461538 11.2 11 2 decreased B-1 B cell number 0.0316437221857804 0.142596500048028 0.879765886287626 0.538461538461538 11.2 11 2 abnormal B cell differentiation 0.00148194337134775 0.0128443698126394 0.879765886287625 0.538461538461538 11.2 11 2 abnormal brain wave pattern 0.014312803719923 0.0764835644539385 0.879765886287625 0.538461538461538 11.2 11 2 abnormal leukocyte cell number 0.0729192379581963 0.248815643924573 0.879765886287625 0.538461538461538 11.2 11 2 short premaxilla 0.184593196561215 0.433798371701485 0.879765886287625 0.538461538461538 11.2 11 2 short hair 0.184593196561215 0.433798371701485 0.879765886287625 0.538461538461538 11.2 11 2 excessive scratching 0.184593196561215 0.433798371701485 0.879765886287625 0.538461538461538 11.2 11 2 abnormal digestion 0.184593196561215 0.433798371701485 0.879765886287625 0.538461538461538 11.2 11 2 abnormal pulmonary alveolus epithelial cell morphology 0.184593196561215 0.433798371701485 0.879765886287625 0.538461538461538 11.2 11 2 abnormal lung interstitium morphology 0.184593196561215 0.433798371701485 0.879765886287625 0.538461538461538 11.2 11 2 abnormal bile duct development 0.184593196561215 0.433798371701485 0.879765886287625 0.538461538461538 11.2 11 2 abnormal soleus morphology 0.184593196561215 0.433798371701485 0.879765886287625 0.538461538461538 11.2 11 2 tracheoesophageal fistula 0.184593196561215 0.433798371701485 0.879765886287625 0.538461538461538 11.2 11 2 small interparietal bone 0.184593196561215 0.433798371701485 0.879765886287625 0.538461538461538 11.2 11 2 increased cochlear inner hair cell number 0.184593196561215 0.433798371701485 0.879765886287625 0.538461538461538 11.2 11 2 empty decidua capsularis 0.184593196561215 0.433798371701485 0.879765886287625 0.538461538461538 11.2 11 2 increased prostaglandin level 0.184593196561215 0.433798371701485 0.879765886287625 0.538461538461538 11.2 11 2 increased leukocyte cell number 7.59581445644039e-05 0.00108902527149253 0.878899121867638 0.537931034482759 11.2 11 2 abnormal lung morphology 0.000322391974637497 0.00373869481077284 0.878709744767472 0.53781512605042 11.2 11 2 abnormal femur morphology 0.00622072517714032 0.0410908082189352 0.877890052841383 0.537313432835821 11.2 11 2 abnormal response/metabolism to endogenous compounds 0.00275286972541927 0.0211350723517915 0.876700499924254 0.536585365853659 11.2 11 2 shortened head 0.0675961019061281 0.240551221017874 0.875277284826974 0.535714285714286 11.2 11 2 abnormal retinal inner nuclear layer morphology 0.0675961019061281 0.240551221017874 0.875277284826974 0.535714285714286 11.2 11 2 enhanced coordination 0.0675961019061281 0.240551221017874 0.875277284826974 0.535714285714286 11.2 11 2 decreased insulin secretion 0.00214328544463663 0.0177899182506223 0.871387163561077 0.533333333333333 11.2 11 2 abnormal long bone epiphyseal plate morphology 0.011000827320648 0.0639358830843734 0.871387163561076 0.533333333333333 11.2 11 2 abnormal eye physiology 0.011000827320648 0.0639358830843734 0.871387163561076 0.533333333333333 11.2 11 2 abnormal hair cycle 0.0626877441106527 0.224529537041395 0.871387163561076 0.533333333333333 11.2 11 2 salivary gland inflammation 0.0626877441106527 0.224529537041395 0.871387163561076 0.533333333333333 11.2 11 2 interdigital webbing 0.167984853183247 0.400251266564489 0.871387163561076 0.533333333333333 11.2 11 2 abnormal prostate gland morphology 0.167984853183247 0.400251266564489 0.871387163561076 0.533333333333333 11.2 11 2 abnormal epidermis stratum spinosum morphology 0.167984853183247 0.400251266564489 0.871387163561076 0.533333333333333 11.2 11 2 no suckling reflex 0.167984853183247 0.400251266564489 0.871387163561076 0.533333333333333 11.2 11 2 audiogenic seizures 0.167984853183247 0.400251266564489 0.871387163561076 0.533333333333333 11.2 11 2 abnormal seizure response to electrical stimulation 0.167984853183247 0.400251266564489 0.871387163561076 0.533333333333333 11.2 11 2 abnormal respiratory system morphology 0.167984853183247 0.400251266564489 0.871387163561076 0.533333333333333 11.2 11 2 abnormal zygomatic bone morphology 0.167984853183247 0.400251266564489 0.871387163561076 0.533333333333333 11.2 11 2 liver vascular congestion 0.167984853183247 0.400251266564489 0.871387163561076 0.533333333333333 11.2 11 2 bicuspid aortic valve 0.167984853183247 0.400251266564489 0.871387163561076 0.533333333333333 11.2 11 2 increased sensitivity to induced morbidity/mortality 1.71255311381599e-05 0.000299998300747695 0.870203213610586 0.532608695652174 11.2 11 2 neuron degeneration 0.0240029927174981 0.110263055188876 0.869069644509053 0.531914893617021 11.2 11 2 decreased food intake 0.00423863403317484 0.0296062900972343 0.86862960924601 0.531645569620253 11.2 11 2 abnormal lumbar vertebrae morphology 0.0581599784227252 0.210671599945544 0.867983307453416 0.53125 11.2 11 2 abnormal depression-related behavior 0.0581599784227252 0.210671599945544 0.867983307453416 0.53125 11.2 11 2 abnormal auditory brainstem response waveform shape 0.0581599784227252 0.210671599945544 0.867983307453416 0.53125 11.2 11 2 increased T cell derived lymphoma incidence 0.0224032478065153 0.105827423614097 0.866941310685765 0.530612244897959 11.2 11 2 abnormal motor capabilities/coordination/movement 0.000301934411833614 0.00352611196918364 0.866436100131752 0.53030303030303 11.2 11 2 abnormal cervical vertebrae morphology 0.0209117173604106 0.100877204196338 0.86497990500548 0.529411764705882 11.2 11 2 abnormal response to novel object 0.0209117173604106 0.100877204196338 0.86497990500548 0.529411764705882 11.2 11 2 short maxilla 0.0539812309085788 0.198862688819956 0.86497990500548 0.529411764705882 11.2 11 2 increased width of hypertrophic chondrocyte zone 0.0539812309085788 0.198862688819956 0.86497990500548 0.529411764705882 11.2 11 2 abnormal skin physiology 0.0539812309085788 0.198862688819956 0.86497990500548 0.529411764705882 11.2 11 2 abnormal heart rate 0.153315735172008 0.377387385917969 0.86497990500548 0.529411764705882 11.2 11 2 abnormal cranial suture morphology 0.153315735172008 0.377387385917969 0.86497990500548 0.529411764705882 11.2 11 2 abnormal duodenum morphology 0.153315735172008 0.377387385917969 0.86497990500548 0.529411764705882 11.2 11 2 abnormal involuntary movement 0.153315735172008 0.377387385917969 0.86497990500548 0.529411764705882 11.2 11 2 abnormal tarsal bone morphology 0.153315735172008 0.377387385917969 0.86497990500548 0.529411764705882 11.2 11 2 common atrium 0.153315735172008 0.377387385917969 0.86497990500548 0.529411764705882 11.2 11 2 decreased body fat mass 0.153315735172008 0.377387385917969 0.86497990500548 0.529411764705882 11.2 11 2 abnormal placenta development 0.0195211451524947 0.0994039888778517 0.863166529942576 0.528301886792453 11.2 11 2 abnormal heart left ventricle morphology 0.00740300667543191 0.0468574531937325 0.862310213940649 0.527777777777778 11.2 11 2 abnormal neuron differentiation 0.0010701379318231 0.0100579673992312 0.860689330079858 0.526785714285714 11.2 11 2 impaired righting response 0.00253312838668009 0.0197528428271684 0.859921542987904 0.526315789473684 11.2 11 2 abnormal frontal bone morphology 0.0465573947563121 0.182380345600514 0.859921542987904 0.526315789473684 11.2 11 2 abnormal reproductive system physiology 0.0465573947563121 0.182380345600514 0.859921542987904 0.526315789473684 11.2 11 2 flaky skin 0.140263536391684 0.377387385917969 0.859921542987904 0.526315789473684 11.2 11 2 stereotypic behavior 0.140263536391684 0.377387385917969 0.859921542987904 0.526315789473684 11.2 11 2 abnormal metatarsal bone morphology 0.140263536391684 0.377387385917969 0.859921542987904 0.526315789473684 11.2 11 2 increased susceptibility to ischemic brain injury 0.140263536391684 0.377387385917969 0.859921542987904 0.526315789473684 11.2 11 2 increased hemoglobin content 0.0158890239791725 0.0840041384658697 0.858464048847247 0.525423728813559 11.2 11 2 abnormal motor coordination/ balance 0.00222673775366281 0.0183107773958223 0.858184327749545 0.525252525252525 11.2 11 2 abnormal male meiosis 0.0148381913120323 0.079036404472549 0.857102128092862 0.524590163934426 11.2 11 2 abnormal anxiety-related response 0.128581800195695 0.377387385917969 0.855826678497486 0.523809523809524 11.2 11 2 dry skin 0.128581800195695 0.377387385917969 0.855826678497486 0.523809523809524 11.2 11 2 abnormal stapes morphology 0.128581800195695 0.377387385917969 0.855826678497486 0.523809523809524 11.2 11 2 increased T cell proliferation 0.00172055026024774 0.0147074528260009 0.855099553027225 0.523364485981308 11.2 11 2 abnormal suckling behavior 0.00436789373329054 0.0303072124450773 0.854058441558442 0.522727272727273 11.2 11 2 hypertension 0.0373922611693777 0.160523478223868 0.854058441558442 0.522727272727273 11.2 11 2 abnormal gametogenesis 0.0373922611693777 0.160523478223868 0.854058441558442 0.522727272727273 11.2 11 2 abnormal photoreceptor outer segment morphology 0.0373922611693777 0.160523478223868 0.854058441558442 0.522727272727273 11.2 11 2 increased total body fat amount 0.00053220863691736 0.00560961434038954 0.853504218040234 0.522388059701492 11.2 11 2 lung inflammation 0.000499426436237355 0.00534332585006633 0.852966295213738 0.522058823529412 11.2 11 2 abnormal carpal bone morphology 0.118076681421065 0.360608649521055 0.852443964353227 0.521739130434783 11.2 11 2 bidirectional circling 0.118076681421065 0.360608649521055 0.852443964353227 0.521739130434783 11.2 11 2 failure of embryo implantation 0.118076681421065 0.360608649521055 0.852443964353227 0.521739130434783 11.2 11 2 abnormal postnatal growth 0.118076681421065 0.360608649521055 0.852443964353227 0.521739130434783 11.2 11 2 abnormal crista ampullaris morphology 0.118076681421065 0.360608649521055 0.852443964353227 0.521739130434783 11.2 11 2 abnormal lens development 0.118076681421065 0.360608649521055 0.852443964353227 0.521739130434783 11.2 11 2 increased B cell number 0.0012465031055611 0.0112343350546494 0.851836810532463 0.521367521367521 11.2 11 2 abnormal intestinal epithelium morphology 0.0323605319204449 0.142596500048028 0.850964026915114 0.520833333333333 11.2 11 2 abnormal cardiovascular system morphology 0.0323605319204449 0.142596500048028 0.850964026915114 0.520833333333333 11.2 11 2 abnormal phalanx morphology 0.0323605319204449 0.142596500048028 0.850964026915114 0.520833333333333 11.2 11 2 abnormal nest building behavior 0.108592248525784 0.336183221167252 0.84960248447205 0.52 11.2 11 2 abnormal primitive streak morphology 0.108592248525784 0.336183221167252 0.84960248447205 0.52 11.2 11 2 abnormal feces composition 0.108592248525784 0.336183221167252 0.84960248447205 0.52 11.2 11 2 diaphragmatic hernia 0.108592248525784 0.336183221167252 0.84960248447205 0.52 11.2 11 2 increased cellular sensitivity to ionizing radiation 0.108592248525784 0.336183221167252 0.84960248447205 0.52 11.2 11 2 abnormal response to infection 0.00805223249441426 0.049213583120038 0.84794795188301 0.518987341772152 11.2 11 2 reduced long term potentiation 0.00198744383208394 0.0166456785599623 0.846101375332742 0.517857142857143 11.2 11 2 seizures 0.00186167302322757 0.0157246575391463 0.845589517271439 0.517543859649123 11.2 11 2 cochlear ganglion degeneration 0.0226577401633958 0.106755968333675 0.845095309488113 0.517241379310345 11.2 11 2 abnormal circulating glucose level 0.0921959521911535 0.290484396549074 0.845095309488113 0.517241379310345 11.2 11 2 short sternum 0.0921959521911535 0.290484396549074 0.845095309488113 0.517241379310345 11.2 11 2 enlarged epididymis 0.0921959521911535 0.290484396549074 0.845095309488113 0.517241379310345 11.2 11 2 impaired swimming 0.017108832892584 0.0901657241955568 0.841680782985131 0.515151515151515 11.2 11 2 abnormal locomotor coordination 0.0786017696386082 0.252744604400809 0.841680782985131 0.515151515151515 11.2 11 2 abnormal T cell subpopulation ratio 0.0786017696386082 0.252744604400809 0.841680782985131 0.515151515151515 11.2 11 2 increased osteoblast cell number 0.0786017696386082 0.252744604400809 0.841680782985131 0.515151515151515 11.2 11 2 diarrhea 0.0786017696386082 0.252744604400809 0.841680782985131 0.515151515151515 11.2 11 2 abnormal T cell differentiation 0.00385344540835733 0.0279459051116293 0.841190578685198 0.514851485148515 11.2 11 2 cochlear outer hair cell degeneration 0.0138875102468364 0.0755085939650392 0.839617839889579 0.513888888888889 11.2 11 2 failure of heart looping 0.0622559974621349 0.223304677270455 0.837872272654882 0.512820512820513 11.2 11 2 altered response to myocardial infarction 0.0495965052288343 0.193675520811186 0.835079365079365 0.511111111111111 11.2 11 2 abnormal hair follicle morphology 0.0256903837770372 0.117688452385599 0.829892536724835 0.507936507936508 11.2 11 2 abnormal epidermal layer morphology 0.0207534209897571 0.100877204196338 0.828764965343415 0.507246376811594 11.2 11 2 decreased IgM level 0.00785932445193734 0.0483734513299968 0.825347377857463 0.505154639175258 11.2 11 2 abnormal dendritic cell physiology 0.00559662814952701 0.0384044483364095 0.824560283276252 0.504672897196262 11.2 11 2 short femur 0.0141285703800129 0.0756193001805988 0.816925465838509 0.5 11.2 11 2 impaired fertilization 0.0266219987489543 0.121844014513383 0.816925465838509 0.5 11.2 11 2 decreased eosinophil cell number 0.0330329945994165 0.145304286588945 0.816925465838509 0.5 11.2 11 2 abnormal seminal vesicle morphology 0.0442536195932715 0.173766185853611 0.816925465838509 0.5 11.2 11 2 cochlear hair cell degeneration 0.0695496564668103 0.245338458517196 0.816925465838509 0.5 11.2 11 2 embryonic lethality, incomplete penetrance 0.0695496564668103 0.245338458517196 0.816925465838509 0.5 11.2 11 2 abnormal cartilage morphology 0.0751457098490352 0.252744604400809 0.816925465838509 0.5 11.2 11 2 abnormal spleen white pulp morphology 0.0751457098490352 0.252744604400809 0.816925465838509 0.5 11.2 11 2 abnormal cytotoxic T cell physiology 0.0751457098490352 0.252744604400809 0.816925465838509 0.5 11.2 11 2 abnormal uterus morphology 0.0952189796314391 0.299629616487293 0.816925465838509 0.5 11.2 11 2 reduced long term depression 0.0952189796314391 0.299629616487293 0.816925465838509 0.5 11.2 11 2 decreased osteoblast cell number 0.103222308368638 0.322975461719479 0.816925465838509 0.5 11.2 11 2 abnormal circulating cholesterol level 0.132405407460397 0.377387385917969 0.816925465838509 0.5 11.2 11 2 abnormal foregut morphology 0.157459615662863 0.378070264441479 0.816925465838509 0.5 11.2 11 2 decreased body height 0.157459615662863 0.378070264441479 0.816925465838509 0.5 11.2 11 2 abnormal vasodilation 0.157459615662863 0.378070264441479 0.816925465838509 0.5 11.2 11 2 apnea 0.157459615662863 0.378070264441479 0.816925465838509 0.5 11.2 11 2 prolonged QT interval 0.157459615662863 0.378070264441479 0.816925465838509 0.5 11.2 11 2 decreased ovulation rate 0.157459615662863 0.378070264441479 0.816925465838509 0.5 11.2 11 2 increased circulating total protein level 0.157459615662863 0.378070264441479 0.816925465838509 0.5 11.2 11 2 abnormal long bone epiphysis morphology 0.172205579800975 0.408157579566389 0.816925465838509 0.5 11.2 11 2 abnormal oogenesis 0.172205579800975 0.408157579566389 0.816925465838509 0.5 11.2 11 2 abnormal tracheal cartilage morphology 0.172205579800975 0.408157579566389 0.816925465838509 0.5 11.2 11 2 abnormal female reproductive system physiology 0.172205579800975 0.408157579566389 0.816925465838509 0.5 11.2 11 2 abnormal retinal layer morphology 0.172205579800975 0.408157579566389 0.816925465838509 0.5 11.2 11 2 decreased susceptibility to viral infection induced morbidity/mortality 0.172205579800975 0.408157579566389 0.816925465838509 0.5 11.2 11 2 abnormal dopamine level 0.188776224288401 0.441750571888428 0.816925465838509 0.5 11.2 11 2 abnormal Peyer's patch T cell area morphology 0.188776224288401 0.441750571888428 0.816925465838509 0.5 11.2 11 2 abnormal hyoid bone morphology 0.188776224288401 0.441750571888428 0.816925465838509 0.5 11.2 11 2 decreased skin tensile strength 0.188776224288401 0.441750571888428 0.816925465838509 0.5 11.2 11 2 abnormal response to tactile stimuli 0.188776224288401 0.441750571888428 0.816925465838509 0.5 11.2 11 2 abnormal mammary gland morphology 0.207522968372114 0.479752215451332 0.816925465838509 0.5 11.2 11 2 thick dermal layer 0.207522968372114 0.479752215451332 0.816925465838509 0.5 11.2 11 2 increased circulating glycerol level 0.207522968372114 0.479752215451332 0.816925465838509 0.5 11.2 11 2 decreased heart rate variability 0.207522968372114 0.479752215451332 0.816925465838509 0.5 11.2 11 2 darkened coat color 0.207522968372114 0.479752215451332 0.816925465838509 0.5 11.2 11 2 decreased mast cell number 0.228910925393573 0.516477031216792 0.816925465838509 0.5 11.2 11 2 mixed cellular infiltration to dermis 0.228910925393573 0.516477031216792 0.816925465838509 0.5 11.2 11 2 reduced male mating frequency 0.228910925393573 0.516477031216792 0.816925465838509 0.5 11.2 11 2 abnormal extraembryonic endoderm formation 0.228910925393573 0.516477031216792 0.816925465838509 0.5 11.2 11 2 large intestinal inflammation 0.228910925393573 0.516477031216792 0.816925465838509 0.5 11.2 11 2 small epididymis 0.228910925393573 0.516477031216792 0.816925465838509 0.5 11.2 11 2 abnormal epididymis epithelium morphology 0.228910925393573 0.516477031216792 0.816925465838509 0.5 11.2 11 2 loose skin 0.228910925393573 0.516477031216792 0.816925465838509 0.5 11.2 11 2 decreased adipocyte glucose uptake 0.228910925393573 0.516477031216792 0.816925465838509 0.5 11.2 11 2 abnormal adrenal gland secretion 0.253577631145596 0.556975150088008 0.816925465838509 0.5 11.2 11 2 absent otoliths 0.253577631145596 0.556975150088008 0.816925465838509 0.5 11.2 11 2 abnormal kidney medulla morphology 0.253577631145596 0.556975150088008 0.816925465838509 0.5 11.2 11 2 abnormal voluntary movement 0.253577631145596 0.556975150088008 0.816925465838509 0.5 11.2 11 2 abnormal pancreas development 0.253577631145596 0.556975150088008 0.816925465838509 0.5 11.2 11 2 abnormal maternal decidual layer morphology 0.253577631145596 0.556975150088008 0.816925465838509 0.5 11.2 11 2 ear inflammation 0.282436901394669 0.591674160109291 0.816925465838509 0.5 11.2 11 2 interstitial pneumonia 0.282436901394669 0.591674160109291 0.816925465838509 0.5 11.2 11 2 increased papilloma incidence 0.282436901394669 0.591674160109291 0.816925465838509 0.5 11.2 11 2 increased circulating parathyroid hormone level 0.282436901394669 0.591674160109291 0.816925465838509 0.5 11.2 11 2 abnormal gastrocnemius morphology 0.282436901394669 0.591674160109291 0.816925465838509 0.5 11.2 11 2 decreased left ventricle systolic pressure 0.282436901394669 0.591674160109291 0.816925465838509 0.5 11.2 11 2 stria vascularis degeneration 0.282436901394669 0.591674160109291 0.816925465838509 0.5 11.2 11 2 small parietal bone 0.282436901394669 0.591674160109291 0.816925465838509 0.5 11.2 11 2 abnormal palatine bone morphology 0.282436901394669 0.591674160109291 0.816925465838509 0.5 11.2 11 2 hydrometra 0.282436901394669 0.591674160109291 0.816925465838509 0.5 11.2 11 2 impaired behavioral response to cocaine 0.282436901394669 0.591674160109291 0.816925465838509 0.5 11.2 11 2 abnormal aorta elastic tissue morphology 0.282436901394669 0.591674160109291 0.816925465838509 0.5 11.2 11 2 absent maxillary shelf 0.316877658644968 0.599070484338175 0.816925465838509 0.5 11.2 11 2 absent trophoblast giant cells 0.316877658644968 0.599070484338175 0.816925465838509 0.5 11.2 11 2 abnormal PNS synaptic transmission 0.316877658644968 0.599070484338175 0.816925465838509 0.5 11.2 11 2 delayed dark adaptation 0.316877658644968 0.599070484338175 0.816925465838509 0.5 11.2 11 2 abnormal tibialis anterior morphology 0.316877658644968 0.599070484338175 0.816925465838509 0.5 11.2 11 2 lymphedema 0.316877658644968 0.599070484338175 0.816925465838509 0.5 11.2 11 2 cochlear ganglion hypoplasia 0.316877658644968 0.599070484338175 0.816925465838509 0.5 11.2 11 2 abnormal submandibular gland morphology 0.316877658644968 0.599070484338175 0.816925465838509 0.5 11.2 11 2 decreased cochlear inner hair cell number 0.316877658644968 0.599070484338175 0.816925465838509 0.5 11.2 11 2 abnormal cochlear inner hair cell physiology 0.316877658644968 0.599070484338175 0.816925465838509 0.5 11.2 11 2 decreased thyroxine level 0.316877658644968 0.599070484338175 0.816925465838509 0.5 11.2 11 2 abnormal developmental vascular remodeling 0.316877658644968 0.599070484338175 0.816925465838509 0.5 11.2 11 2 increased platelet aggregation 0.316877658644968 0.599070484338175 0.816925465838509 0.5 11.2 11 2 ventricular premature beat 0.316877658644968 0.599070484338175 0.816925465838509 0.5 11.2 11 2 increased serotonin level 0.316877658644968 0.599070484338175 0.816925465838509 0.5 11.2 11 2 aorta stenosis 0.316877658644968 0.599070484338175 0.816925465838509 0.5 11.2 11 2 sinus bradycardia 0.316877658644968 0.599070484338175 0.816925465838509 0.5 11.2 11 2 abnormal pulmonary interalveolar septum morphology 0.316877658644968 0.599070484338175 0.816925465838509 0.5 11.2 11 2 decreased macrophage cytokine production 0.316877658644968 0.599070484338175 0.816925465838509 0.5 11.2 11 2 absent corpus luteum 0.0513462725928626 0.198862688819956 0.816925465838509 0.5 11.2 11 2 increased bone marrow cell number 0.0879198744460336 0.279489696721417 0.816925465838509 0.5 11.2 11 2 abnormal heart tube morphology 0.121704160271655 0.369939039549948 0.816925465838509 0.5 11.2 11 2 delayed eyelid opening 0.121704160271655 0.369939039549948 0.816925465838509 0.5 11.2 11 2 abnormal microglial cell physiology 0.121704160271655 0.369939039549948 0.816925465838509 0.5 11.2 11 2 abnormal Schwann cell morphology 0.144265259093371 0.377387385917969 0.816925465838509 0.5 11.2 11 2 small seminal vesicle 0.144265259093371 0.377387385917969 0.816925465838509 0.5 11.2 11 2 no spontaneous movement 0.144265259093371 0.377387385917969 0.816925465838509 0.5 11.2 11 2 abnormal ocular fundus morphology 0.144265259093371 0.377387385917969 0.816925465838509 0.5 11.2 11 2 increased anxiety-related response 0.00326225923435445 0.0244056235953585 0.811048304213772 0.496402877697842 11.2 11 2 abnormal eye electrophysiology 0.00596356211451711 0.0401604186799081 0.810174015707613 0.495867768595041 11.2 11 2 abnormal skeletal muscle fiber morphology 0.0337034748505866 0.148122603694054 0.805419473361911 0.492957746478873 11.2 11 2 internal hemorrhage 0.0389360535929886 0.162642205394726 0.804732548437935 0.492537313432836 11.2 11 2 increased sarcoma incidence 0.0759720576862424 0.252744604400809 0.800253517556091 0.489795918367347 11.2 11 2 abnormal T-helper 1 physiology 0.0820334005261114 0.26296144820709 0.799544072948328 0.48936170212766 11.2 11 2 decreased osteoclast cell number 0.0886352793900918 0.281045579965396 0.798771566597653 0.488888888888889 11.2 11 2 lethality at weaning, complete penetrance 0.0886352793900918 0.281045579965396 0.798771566597653 0.488888888888889 11.2 11 2 decreased exploration in new environment 0.0275021219673152 0.12552574017192 0.797474859509021 0.488095238095238 11.2 11 2 acanthosis 0.112300557580738 0.347231369772637 0.795978659022137 0.487179487179487 11.2 11 2 impaired macrophage chemotaxis 0.112300557580738 0.347231369772637 0.795978659022137 0.487179487179487 11.2 11 2 abnormal long bone metaphysis morphology 0.121726674923269 0.369939039549948 0.794846399194225 0.486486486486487 11.2 11 2 abnormal pancreatic beta cell physiology 0.121726674923269 0.369939039549948 0.794846399194225 0.486486486486487 11.2 11 2 abnormal calcium ion homeostasis 0.121726674923269 0.369939039549948 0.794846399194225 0.486486486486487 11.2 11 2 abnormal humerus morphology 0.121726674923269 0.369939039549948 0.794846399194225 0.486486486486487 11.2 11 2 abnormal intestinal goblet cell morphology 0.132076552996347 0.377387385917969 0.793584738243123 0.485714285714286 11.2 11 2 impaired behavioral response to xenobiotic 0.132076552996347 0.377387385917969 0.793584738243123 0.485714285714286 11.2 11 2 absent vibrissae 0.143466094739622 0.377387385917969 0.792170148691888 0.484848484848485 11.2 11 2 increased eosinophil cell number 0.0606095859732423 0.21897798853804 0.790573031456622 0.483870967741935 11.2 11 2 increased lung adenoma incidence 0.156031480799892 0.377387385917969 0.790573031456622 0.483870967741935 11.2 11 2 abnormal middle ear morphology 0.169934232378358 0.403928717669532 0.788755622188906 0.482758620689655 11.2 11 2 aphagia 0.169934232378358 0.403928717669532 0.788755622188906 0.482758620689655 11.2 11 2 stomach inflammation 0.169934232378358 0.403928717669532 0.788755622188906 0.482758620689655 11.2 11 2 abnormal CD8-positive, alpha-beta T cell physiology 0.169934232378358 0.403928717669532 0.788755622188906 0.482758620689655 11.2 11 2 increased retinal apoptosis 0.169934232378358 0.403928717669532 0.788755622188906 0.482758620689655 11.2 11 2 abnormal cochlea morphology 0.0816309921623678 0.261840223086899 0.78666896710375 0.481481481481481 11.2 11 2 abnormal brain commissure morphology 0.185368013188472 0.435208053616163 0.78666896710375 0.481481481481481 11.2 11 2 decreased susceptibility to pharmacologically induced seizures 0.185368013188472 0.435208053616163 0.78666896710375 0.481481481481481 11.2 11 2 abnormal hair growth 0.0880431271914032 0.279524287030779 0.785505255613951 0.480769230769231 11.2 11 2 increased susceptibility to injury 0.0880431271914032 0.279524287030779 0.785505255613951 0.480769230769231 11.2 11 2 abnormal inner ear vestibule morphology 0.202567954558629 0.47172777602813 0.784248447204969 0.48 11.2 11 2 abnormal trabecular bone morphology 0.0169668053783927 0.0895120432211067 0.78260086643353 0.478991596638655 11.2 11 2 abnormal CD4-positive, alpha-beta T cell physiology 0.0559261946076256 0.203089648301414 0.782407488408713 0.47887323943662 11.2 11 2 blistering 0.221823736649225 0.510913467513839 0.781406967323792 0.478260869565217 11.2 11 2 abnormal circulating insulin level 0.221823736649225 0.510913467513839 0.781406967323792 0.478260869565217 11.2 11 2 conjunctivitis 0.221823736649225 0.510913467513839 0.781406967323792 0.478260869565217 11.2 11 2 abnormal corneal stroma morphology 0.221823736649225 0.510913467513839 0.781406967323792 0.478260869565217 11.2 11 2 abnormal basicranium morphology 0.221823736649225 0.510913467513839 0.781406967323792 0.478260869565217 11.2 11 2 decreased IgG level 0.0222218133630243 0.105827423614097 0.780127021431369 0.477477477477477 11.2 11 2 skin lesions 0.0747634065013659 0.252744604400809 0.778024253179533 0.476190476190476 11.2 11 2 abnormal optic nerve morphology 0.129656038574601 0.377387385917969 0.778024253179533 0.476190476190476 11.2 11 2 increased incidence of induced tumors 0.243498428009043 0.54666276143727 0.778024253179533 0.476190476190476 11.2 11 2 decreased cochlear outer hair cell number 0.243498428009043 0.54666276143727 0.778024253179533 0.476190476190476 11.2 11 2 abnormal clavicle morphology 0.243498428009043 0.54666276143727 0.778024253179533 0.476190476190476 11.2 11 2 abnormal female reproductive system morphology 0.14039361716847 0.377387385917969 0.776079192546584 0.475 11.2 11 2 perinatal lethality 0.14039361716847 0.377387385917969 0.776079192546584 0.475 11.2 11 2 abnormal compact bone morphology 0.152152795352781 0.377387385917969 0.773929388689114 0.473684210526316 11.2 11 2 short vibrissae 0.2680564571545 0.584903892255981 0.773929388689114 0.473684210526316 11.2 11 2 unresponsive to tactile stimuli 0.2680564571545 0.584903892255981 0.773929388689114 0.473684210526316 11.2 11 2 abnormal long term depression 0.2680564571545 0.584903892255981 0.773929388689114 0.473684210526316 11.2 11 2 abnormal nasal septum morphology 0.2680564571545 0.584903892255981 0.773929388689114 0.473684210526316 11.2 11 2 maternal imprinting 0.2680564571545 0.584903892255981 0.773929388689114 0.473684210526316 11.2 11 2 abnormal photoreceptor inner segment morphology 0.2680564571545 0.584903892255981 0.773929388689114 0.473684210526316 11.2 11 2 decreased fertilization frequency 0.2680564571545 0.584903892255981 0.773929388689114 0.473684210526316 11.2 11 2 shortened RR interval 0.2680564571545 0.584903892255981 0.773929388689114 0.473684210526316 11.2 11 2 right-sided stomach 0.2680564571545 0.584903892255981 0.773929388689114 0.473684210526316 11.2 11 2 head tilt 0.165054381796528 0.395351732998425 0.77154071773637 0.472222222222222 11.2 11 2 decreased anxiety-related response 0.0231598740394097 0.106755968333675 0.770433772660708 0.471544715447154 11.2 11 2 impaired synaptic plasticity 0.179238349291607 0.424018443997026 0.768871026671538 0.470588235294118 11.2 11 2 decreased pancreatic beta cell number 0.179238349291607 0.424018443997026 0.768871026671538 0.470588235294118 11.2 11 2 abnormal glutamate-mediated receptor currents 0.296106650034965 0.599070484338175 0.768871026671538 0.470588235294118 11.2 11 2 absence seizures 0.296106650034965 0.599070484338175 0.768871026671538 0.470588235294118 11.2 11 2 increased regulatory T cell number 0.296106650034965 0.599070484338175 0.768871026671538 0.470588235294118 11.2 11 2 abnormal circulating chemokine level 0.296106650034965 0.599070484338175 0.768871026671538 0.470588235294118 11.2 11 2 abnormal survival 0.296106650034965 0.599070484338175 0.768871026671538 0.470588235294118 11.2 11 2 abnormal electroretinogram waveform feature 0.296106650034965 0.599070484338175 0.768871026671538 0.470588235294118 11.2 11 2 cochlear inner hair cell degeneration 0.116885458858506 0.358290300567509 0.768871026671538 0.470588235294118 11.2 11 2 abnormal long term potentiation 0.194868030040671 0.455791466597243 0.765867624223602 0.46875 11.2 11 2 increased circulating corticosterone level 0.147134999353293 0.377387385917969 0.762463768115942 0.466666666666667 11.2 11 2 abnormal response to new environment 0.212135545471724 0.490187802471818 0.762463768115942 0.466666666666667 11.2 11 2 abnormal enteric neuron morphology 0.32847131186265 0.599070484338175 0.762463768115942 0.466666666666667 11.2 11 2 joint inflammation 0.32847131186265 0.599070484338175 0.762463768115942 0.466666666666667 11.2 11 2 arthritis 0.32847131186265 0.599070484338175 0.762463768115942 0.466666666666667 11.2 11 2 dilated ureter 0.32847131186265 0.599070484338175 0.762463768115942 0.466666666666667 11.2 11 2 decreased aggression towards males 0.32847131186265 0.599070484338175 0.762463768115942 0.466666666666667 11.2 11 2 abnormal Muller cell morphology 0.32847131186265 0.599070484338175 0.762463768115942 0.466666666666667 11.2 11 2 abnormal aorta wall morphology 0.32847131186265 0.599070484338175 0.762463768115942 0.466666666666667 11.2 11 2 decreased trabecular bone mass 0.32847131186265 0.599070484338175 0.762463768115942 0.466666666666667 11.2 11 2 impaired macrophage phagocytosis 0.159065424357713 0.381557611465583 0.759930665896288 0.465116279069767 11.2 11 2 abnormal axon guidance 0.159065424357713 0.381557611465583 0.759930665896288 0.465116279069767 11.2 11 2 abnormal CNS synaptic transmission 0.0515756054523972 0.198862688819956 0.759163059163059 0.464646464646465 11.2 11 2 abnormal jaw morphology 0.231268938152804 0.521088300412227 0.758573646850044 0.464285714285714 11.2 11 2 reddish skin 0.231268938152804 0.521088300412227 0.758573646850044 0.464285714285714 11.2 11 2 straub tail 0.231268938152804 0.521088300412227 0.758573646850044 0.464285714285714 11.2 11 2 decreased tumor growth/size 0.131426981558311 0.377387385917969 0.75641246836899 0.462962962962963 11.2 11 2 abnormal social investigation 0.07991693756633 0.25650758993064 0.755656055900621 0.4625 11.2 11 2 increased vascular permeability 0.186311856300247 0.43701154412717 0.754085045389393 0.461538461538462 11.2 11 2 increased percent body fat/body weight 0.141607457430308 0.377387385917969 0.754085045389393 0.461538461538462 11.2 11 2 abnormal xiphoid process morphology 0.252541693528849 0.556173052370971 0.754085045389393 0.461538461538462 11.2 11 2 increased susceptibility to otitis media 0.252541693528849 0.556173052370971 0.754085045389393 0.461538461538462 11.2 11 2 pulmonary edema 0.252541693528849 0.556173052370971 0.754085045389393 0.461538461538462 11.2 11 2 decreased Peyer's patch number 0.252541693528849 0.556173052370971 0.754085045389393 0.461538461538462 11.2 11 2 abnormal membranous labyrinth morphology 0.366302934109058 0.599070484338175 0.754085045389393 0.461538461538462 11.2 11 2 absent teeth 0.366302934109058 0.599070484338175 0.754085045389393 0.461538461538462 11.2 11 2 abnormal sympathetic ganglion morphology 0.366302934109058 0.599070484338175 0.754085045389393 0.461538461538462 11.2 11 2 lymphoid hypoplasia 0.366302934109058 0.599070484338175 0.754085045389393 0.461538461538462 11.2 11 2 increased synaptic depression 0.366302934109058 0.599070484338175 0.754085045389393 0.461538461538462 11.2 11 2 absent lateral semicircular canal 0.366302934109058 0.599070484338175 0.754085045389393 0.461538461538462 11.2 11 2 abnormal vestibulocochlear ganglion morphology 0.366302934109058 0.599070484338175 0.754085045389393 0.461538461538462 11.2 11 2 small otic vesicle 0.366302934109058 0.599070484338175 0.754085045389393 0.461538461538462 11.2 11 2 decreased endocochlear potential 0.366302934109058 0.599070484338175 0.754085045389393 0.461538461538462 11.2 11 2 increased circulating thyroid-stimulating hormone level 0.366302934109058 0.599070484338175 0.754085045389393 0.461538461538462 11.2 11 2 small pituitary gland 0.366302934109058 0.599070484338175 0.754085045389393 0.461538461538462 11.2 11 2 abnormal cytokine secretion 0.0235174651969513 0.108232552594665 0.753268936032911 0.461038961038961 11.2 11 2 abnormal immune system physiology 0.0414499688099788 0.165032564239577 0.751044379883791 0.459677419354839 11.2 11 2 impaired skeletal muscle contractility 0.201882932638799 0.471534079754942 0.750688265905657 0.459459459459459 11.2 11 2 decreased circulating chloride level 0.201882932638799 0.471534079754942 0.750688265905657 0.459459459459459 11.2 11 2 increased insulin secretion 0.201882932638799 0.471534079754942 0.750688265905657 0.459459459459459 11.2 11 2 abnormal lymph node morphology 0.164619547791217 0.394500120549761 0.7488483436853 0.458333333333333 11.2 11 2 abnormal osteoclast morphology 0.164619547791217 0.394500120549761 0.7488483436853 0.458333333333333 11.2 11 2 abnormal adrenal gland morphology 0.276285685176147 0.591674160109291 0.7488483436853 0.458333333333333 11.2 11 2 abnormal tumor morphology 0.276285685176147 0.591674160109291 0.7488483436853 0.458333333333333 11.2 11 2 increased B cell proliferation 0.135898225191436 0.377387385917969 0.74769449415728 0.457627118644068 11.2 11 2 abnormal inner ear morphology 0.177623439255482 0.420598101045228 0.745888468809074 0.456521739130435 11.2 11 2 decreased susceptibility to injury 0.121356618953278 0.369939039549948 0.744843807088053 0.455882352941176 11.2 11 2 increased neutrophil cell number 0.0376035812912238 0.160523478223868 0.743683872349539 0.455172413793103 11.2 11 2 abnormal T-helper 2 physiology 0.157174022133937 0.378070264441479 0.742659514398645 0.454545454545455 11.2 11 2 abnormal middle ear ossicle morphology 0.237702976124879 0.534858573596234 0.742659514398645 0.454545454545455 11.2 11 2 head tossing 0.237702976124879 0.534858573596234 0.742659514398645 0.454545454545455 11.2 11 2 decreased sensitivity to xenobiotic induced morbidity/mortality 0.237702976124879 0.534858573596234 0.742659514398645 0.454545454545455 11.2 11 2 abnormal temporal bone morphology 0.302909134849101 0.599070484338175 0.742659514398645 0.454545454545455 11.2 11 2 social withdrawal 0.411294210843682 0.633299809210644 0.742659514398645 0.454545454545455 11.2 11 2 abnormal hypothalamus secretion 0.411294210843682 0.633299809210644 0.742659514398645 0.454545454545455 11.2 11 2 abnormal vestibular ganglion morphology 0.411294210843682 0.633299809210644 0.742659514398645 0.454545454545455 11.2 11 2 retinal detachment 0.411294210843682 0.633299809210644 0.742659514398645 0.454545454545455 11.2 11 2 pulmonary hypertension 0.411294210843682 0.633299809210644 0.742659514398645 0.454545454545455 11.2 11 2 abnormal ureter development 0.411294210843682 0.633299809210644 0.742659514398645 0.454545454545455 11.2 11 2 abnormal hair medulla 0.411294210843682 0.633299809210644 0.742659514398645 0.454545454545455 11.2 11 2 abnormal pituitary gland development 0.411294210843682 0.633299809210644 0.742659514398645 0.454545454545455 11.2 11 2 abnormal Bruch membrane morphology 0.411294210843682 0.633299809210644 0.742659514398645 0.454545454545455 11.2 11 2 enhanced behavioral response to addictive substance 0.411294210843682 0.633299809210644 0.742659514398645 0.454545454545455 11.2 11 2 aberrant origin of the right subclavian artery 0.411294210843682 0.633299809210644 0.742659514398645 0.454545454545455 11.2 11 2 increased pancreatic beta cell proliferation 0.411294210843682 0.633299809210644 0.742659514398645 0.454545454545455 11.2 11 2 decreased embryonic cilium length 0.411294210843682 0.633299809210644 0.742659514398645 0.454545454545455 11.2 11 2 chylous ascites 0.411294210843682 0.633299809210644 0.742659514398645 0.454545454545455 11.2 11 2 abnormal cued conditioning behavior 0.182017935923347 0.430389368449929 0.736834733893557 0.450980392156863 11.2 11 2 decreased paired-pulse facilitation 0.332922102226763 0.599070484338175 0.735232919254658 0.45 11.2 11 2 abnormal male reproductive system physiology 0.332922102226763 0.599070484338175 0.735232919254658 0.45 11.2 11 2 abnormal incus morphology 0.332922102226763 0.599070484338175 0.735232919254658 0.45 11.2 11 2 enhanced behavioral response to xenobiotic 0.332922102226763 0.599070484338175 0.735232919254658 0.45 11.2 11 2 absent long term depression 0.281103386594541 0.591674160109291 0.732415934889698 0.448275862068966 11.2 11 2 increased double-positive T cell number 0.281103386594541 0.591674160109291 0.732415934889698 0.448275862068966 11.2 11 2 increased grooming behavior 0.242140662822719 0.544351467484423 0.730933311539719 0.447368421052632 11.2 11 2 hyporesponsive to tactile stimuli 0.242140662822719 0.544351467484423 0.730933311539719 0.447368421052632 11.2 11 2 enhanced long term potentiation 0.185516294481274 0.435350738228462 0.729397737355812 0.446428571428571 11.2 11 2 wrinkled skin 0.306280637801151 0.599070484338175 0.726155969634231 0.444444444444444 11.2 11 2 abnormal palate morphology 0.306280637801151 0.599070484338175 0.726155969634231 0.444444444444444 11.2 11 2 increased susceptibility to bacterial infection induced morbidity/mortality 0.155745112070034 0.377387385917969 0.72615596963423 0.444444444444444 11.2 11 2 abnormal cartilage development 0.227455205842116 0.515295832907344 0.72615596963423 0.444444444444444 11.2 11 2 abnormal systemic arterial blood pressure 0.262072877672062 0.574619905869771 0.72615596963423 0.444444444444444 11.2 11 2 abnormal epidermis stratum granulosum morphology 0.262072877672062 0.574619905869771 0.72615596963423 0.444444444444444 11.2 11 2 impaired wound healing 0.262072877672062 0.574619905869771 0.72615596963423 0.444444444444444 11.2 11 2 absent spleen 0.366973595365247 0.599070484338175 0.72615596963423 0.444444444444444 11.2 11 2 decreased tumor latency 0.366973595365247 0.599070484338175 0.72615596963423 0.444444444444444 11.2 11 2 abnormal macrophage chemotaxis 0.366973595365247 0.599070484338175 0.72615596963423 0.444444444444444 11.2 11 2 impaired leukocyte tethering or rolling 0.366973595365247 0.599070484338175 0.72615596963423 0.444444444444444 11.2 11 2 dehydration 0.166558601356868 0.398762772738412 0.723562555456965 0.442857142857143 11.2 11 2 abnormal male reproductive system morphology 0.245188950384431 0.550209755598801 0.721934132601473 0.441860465116279 11.2 11 2 abnormal retinal photoreceptor morphology 0.283859260466936 0.592863064997064 0.720816587504567 0.441176470588235 11.2 11 2 abnormal vision 0.283859260466936 0.592863064997064 0.720816587504567 0.441176470588235 11.2 11 2 decreased regulatory T cell number 0.283859260466936 0.592863064997064 0.720816587504567 0.441176470588235 11.2 11 2 decreased inflammatory response 0.14993536374598 0.377387385917969 0.719672434191068 0.44047619047619 11.2 11 2 mandible hypoplasia 0.334206759232768 0.599070484338175 0.718894409937888 0.44 11.2 11 2 increased pre-B cell number 0.334206759232768 0.599070484338175 0.718894409937888 0.44 11.2 11 2 abnormal serotonin level 0.307705119476858 0.599070484338175 0.714809782608696 0.4375 11.2 11 2 abnormal pituitary gland morphology 0.405907168005265 0.633299809210644 0.714809782608696 0.4375 11.2 11 2 paternal imprinting 0.405907168005265 0.633299809210644 0.714809782608696 0.4375 11.2 11 2 decreased cochlear coiling 0.405907168005265 0.633299809210644 0.714809782608696 0.4375 11.2 11 2 impaired muscle relaxation 0.405907168005265 0.633299809210644 0.714809782608696 0.4375 11.2 11 2 abnormal pulmonary elastic fiber morphology 0.405907168005265 0.633299809210644 0.714809782608696 0.4375 11.2 11 2 decreased aggression towards mice 0.405907168005265 0.633299809210644 0.714809782608696 0.4375 11.2 11 2 abnormal molar crown morphology 0.405907168005265 0.633299809210644 0.714809782608696 0.4375 11.2 11 2 bowed radius 0.405907168005265 0.633299809210644 0.714809782608696 0.4375 11.2 11 2 sepsis 0.405907168005265 0.633299809210644 0.714809782608696 0.4375 11.2 11 2 decreased circulating prolactin level 0.405907168005265 0.633299809210644 0.714809782608696 0.4375 11.2 11 2 impaired behavioral response to addictive substance 0.405907168005265 0.633299809210644 0.714809782608696 0.4375 11.2 11 2 abnormal response to injury 0.285281104226448 0.595582666188241 0.712191431756649 0.435897435897436 11.2 11 2 abnormal immune system morphology 0.265787333985681 0.582507483074344 0.710369970294356 0.434782608695652 11.2 11 2 abnormal B cell morphology 0.365282518079775 0.599070484338175 0.710369970294356 0.434782608695652 11.2 11 2 decreased effector memory CD8-positive, alpha-beta T cell number 0.365282518079775 0.599070484338175 0.710369970294356 0.434782608695652 11.2 11 2 gastrointestinal hemorrhage 0.333843500394342 0.599070484338175 0.708002070393375 0.433333333333333 11.2 11 2 abnormal pain threshold 0.333843500394342 0.599070484338175 0.708002070393375 0.433333333333333 11.2 11 2 abnormal thrombosis 0.266449351689938 0.583701243794558 0.704798441115577 0.431372549019608 11.2 11 2 abnormal inflammatory response 0.219837852204791 0.507749913982745 0.703463595583161 0.430555555555556 11.2 11 2 abnormal humoral immune response 0.175048303124782 0.41469776573609 0.700221827861579 0.428571428571429 11.2 11 2 abnormal stria vascularis morphology 0.362539412537411 0.599070484338175 0.700221827861579 0.428571428571429 11.2 11 2 abnormal muscle morphology 0.307380467896899 0.599070484338175 0.700221827861579 0.428571428571429 11.2 11 2 decreased circulating progesterone level 0.362539412537411 0.599070484338175 0.700221827861579 0.428571428571429 11.2 11 2 abnormal salivary gland morphology 0.399989857890053 0.629531649162611 0.700221827861579 0.428571428571429 11.2 11 2 increased vasoconstriction 0.399989857890053 0.629531649162611 0.700221827861579 0.428571428571429 11.2 11 2 abnormal tumor vascularization 0.399989857890053 0.629531649162611 0.700221827861579 0.428571428571429 11.2 11 2 abnormal interparietal bone morphology 0.450846911331655 0.686761599471826 0.700221827861579 0.428571428571429 11.2 11 2 abnormal vasoconstriction 0.450846911331655 0.686761599471826 0.700221827861579 0.428571428571429 11.2 11 2 abnormal pinna reflex 0.450846911331655 0.686761599471826 0.700221827861579 0.428571428571429 11.2 11 2 abnormal vascular endothelial cell migration 0.450846911331655 0.686761599471826 0.700221827861579 0.428571428571429 11.2 11 2 abnormal hair cuticle 0.450846911331655 0.686761599471826 0.700221827861579 0.428571428571429 11.2 11 2 abnormal decidualization 0.450846911331655 0.686761599471826 0.700221827861579 0.428571428571429 11.2 11 2 decreased cornea thickness 0.450846911331655 0.686761599471826 0.700221827861579 0.428571428571429 11.2 11 2 increased lung compliance 0.450846911331655 0.686761599471826 0.700221827861579 0.428571428571429 11.2 11 2 abnormal excitatory postsynaptic potential 0.220486851167642 0.509012568240843 0.69737539766702 0.426829268292683 11.2 11 2 decreased T cell proliferation 0.142300553336401 0.377387385917969 0.695490599294947 0.425675675675676 11.2 11 2 abnormal stomach morphology 0.39409447408231 0.621038963750234 0.691244624940277 0.423076923076923 11.2 11 2 abnormal tectorial membrane morphology 0.39409447408231 0.621038963750234 0.691244624940277 0.423076923076923 11.2 11 2 thin dermal layer 0.438913332245789 0.670431018705189 0.687937234390324 0.421052631578947 11.2 11 2 decreased grooming behavior 0.438913332245789 0.670431018705189 0.687937234390324 0.421052631578947 11.2 11 2 altered susceptibility to infection 0.438913332245789 0.670431018705189 0.687937234390324 0.421052631578947 11.2 11 2 abnormal food intake 0.281621158738638 0.591674160109291 0.686690971284544 0.420289855072464 11.2 11 2 abnormal T cell proliferation 0.388374605844099 0.612413205728809 0.685163293929072 0.419354838709677 11.2 11 2 increased susceptibility to pharmacologically induced seizures 0.258722802216458 0.568025569738252 0.680771221532091 0.416666666666667 11.2 11 2 abnormal hair shaft morphology 0.348496307073018 0.599070484338175 0.680771221532091 0.416666666666667 11.2 11 2 abnormal reflex 0.382871166556987 0.60392645961351 0.680771221532091 0.416666666666667 11.2 11 2 abnormal malleus morphology 0.42885168443951 0.655867546906413 0.680771221532091 0.416666666666667 11.2 11 2 increased stereotypic behavior 0.42885168443951 0.655867546906413 0.680771221532091 0.416666666666667 11.2 11 2 abnormal adipose tissue distribution 0.503335146164405 0.726455570689851 0.680771221532091 0.416666666666667 11.2 11 2 abnormal supraoccipital bone morphology 0.503335146164405 0.726455570689851 0.680771221532091 0.416666666666667 11.2 11 2 abnormal esophagus morphology 0.503335146164405 0.726455570689851 0.680771221532091 0.416666666666667 11.2 11 2 abnormal tracheal ciliated epithelium morphology 0.503335146164405 0.726455570689851 0.680771221532091 0.416666666666667 11.2 11 2 increased growth rate 0.503335146164405 0.726455570689851 0.680771221532091 0.416666666666667 11.2 11 2 abnormal AMPA-mediated synaptic currents 0.503335146164405 0.726455570689851 0.680771221532091 0.416666666666667 11.2 11 2 small thyroid gland 0.503335146164405 0.726455570689851 0.680771221532091 0.416666666666667 11.2 11 2 absent tail 0.503335146164405 0.726455570689851 0.680771221532091 0.416666666666667 11.2 11 2 impaired sperm capacitation 0.503335146164405 0.726455570689851 0.680771221532091 0.416666666666667 11.2 11 2 bowed ulna 0.503335146164405 0.726455570689851 0.680771221532091 0.416666666666667 11.2 11 2 decreased cochlear nerve compound action potential 0.503335146164405 0.726455570689851 0.680771221532091 0.416666666666667 11.2 11 2 increased placenta weight 0.503335146164405 0.726455570689851 0.680771221532091 0.416666666666667 11.2 11 2 abnormal anogenital distance 0.503335146164405 0.726455570689851 0.680771221532091 0.416666666666667 11.2 11 2 abnormal patella morphology 0.503335146164405 0.726455570689851 0.680771221532091 0.416666666666667 11.2 11 2 abnormal somatic nervous system physiology 0.503335146164405 0.726455570689851 0.680771221532091 0.416666666666667 11.2 11 2 decreased keratinocyte proliferation 0.503335146164405 0.726455570689851 0.680771221532091 0.416666666666667 11.2 11 2 abnormal behavioral response to addictive substance 0.503335146164405 0.726455570689851 0.680771221532091 0.416666666666667 11.2 11 2 persistent right dorsal aorta 0.503335146164405 0.726455570689851 0.680771221532091 0.416666666666667 11.2 11 2 decreased compensatory feeding amount 0.503335146164405 0.726455570689851 0.680771221532091 0.416666666666667 11.2 11 2 decreased monocyte cell number 0.317922626836595 0.599070484338175 0.678676540850454 0.415384615384615 11.2 11 2 arrested B cell differentiation 0.377587584533457 0.599070484338175 0.677450386305105 0.414634146341463 11.2 11 2 increased tumor growth/size 0.377587584533457 0.599070484338175 0.677450386305105 0.414634146341463 11.2 11 2 delayed wound healing 0.372514173350127 0.599070484338175 0.674851471779638 0.41304347826087 11.2 11 2 abnormal lymphocyte physiology 0.372514173350127 0.599070484338175 0.674851471779638 0.41304347826087 11.2 11 2 lung hemorrhage 0.412084116140492 0.633299809210644 0.672762148337596 0.411764705882353 11.2 11 2 increased susceptibility to viral infection induced morbidity/mortality 0.412084116140492 0.633299809210644 0.672762148337596 0.411764705882353 11.2 11 2 distended urinary bladder 0.482767530584476 0.710268388834351 0.672762148337596 0.411764705882353 11.2 11 2 enlarged sebaceous gland 0.482767530584476 0.710268388834351 0.672762148337596 0.411764705882353 11.2 11 2 decreased vasoconstriction 0.482767530584476 0.710268388834351 0.672762148337596 0.411764705882353 11.2 11 2 pancytopenia 0.482767530584476 0.710268388834351 0.672762148337596 0.411764705882353 11.2 11 2 decreased macrophage cell number 0.398100856713381 0.62715381955322 0.66839356295878 0.409090909090909 11.2 11 2 abnormal basisphenoid bone morphology 0.467199589226096 0.704125403332271 0.66839356295878 0.409090909090909 11.2 11 2 intestinal ulcer 0.467199589226096 0.704125403332271 0.66839356295878 0.409090909090909 11.2 11 2 increased coping response 0.467199589226096 0.704125403332271 0.66839356295878 0.409090909090909 11.2 11 2 impaired humoral immune response 0.467199589226096 0.704125403332271 0.66839356295878 0.409090909090909 11.2 11 2 increased dopamine level 0.443569517569054 0.677335282352991 0.663751940993789 0.40625 11.2 11 2 abnormal T cell activation 0.365075368551311 0.599070484338175 0.662371999328521 0.405405405405405 11.2 11 2 abnormal nervous system electrophysiology 0.355919852721723 0.599070484338175 0.661320615202603 0.404761904761905 11.2 11 2 increased systemic arterial blood pressure 0.417442700160119 0.638811883511717 0.66049292982688 0.404255319148936 11.2 11 2 abnormal hearing physiology 0.509574152258473 0.735033751083185 0.653540372670807 0.4 11.2 11 2 nuclear cataracts 0.509574152258473 0.735033751083185 0.653540372670807 0.4 11.2 11 2 abnormal digestive system physiology 0.435720968307591 0.666168351976111 0.653540372670807 0.4 11.2 11 2 arrested T cell differentiation 0.477477109977343 0.710268388834351 0.653540372670807 0.4 11.2 11 2 abnormal spleen marginal zone morphology 0.477477109977343 0.710268388834351 0.653540372670807 0.4 11.2 11 2 decreased chondrocyte number 0.532430644310991 0.759609074170285 0.653540372670807 0.4 11.2 11 2 hyperpigmentation 0.532430644310991 0.759609074170285 0.653540372670807 0.4 11.2 11 2 increased airway responsiveness 0.532430644310991 0.759609074170285 0.653540372670807 0.4 11.2 11 2 abnormal bronchus morphology 0.532430644310991 0.759609074170285 0.653540372670807 0.4 11.2 11 2 abnormal rostral migratory stream morphology 0.532430644310991 0.759609074170285 0.653540372670807 0.4 11.2 11 2 abnormal microglial cell activation 0.532430644310991 0.759609074170285 0.653540372670807 0.4 11.2 11 2 abnormal excitatory postsynaptic currents 0.414647887984797 0.634730228530574 0.649351011307533 0.397435897435897 11.2 11 2 abnormal intestinal mucosa morphology 0.473170388338144 0.710268388834351 0.645941066011845 0.395348837209302 11.2 11 2 decreased threshold for auditory brainstem response 0.484957059619067 0.710268388834351 0.644941157240928 0.394736842105263 11.2 11 2 abnormal NK cell physiology 0.460093995779313 0.700632883073793 0.642826596069647 0.39344262295082 11.2 11 2 increased circulating luteinizing hormone level 0.513948710870909 0.740699547098137 0.641870008873114 0.392857142857143 11.2 11 2 abnormal respiration 0.513948710870909 0.740699547098137 0.641870008873114 0.392857142857143 11.2 11 2 abnormal spleen germinal center morphology 0.513948710870909 0.740699547098137 0.641870008873114 0.392857142857143 11.2 11 2 abnormal innervation pattern to muscle 0.532717706391589 0.759609074170285 0.63933297326492 0.391304347826087 11.2 11 2 abnormal cochlear ganglion morphology 0.532717706391589 0.759609074170285 0.63933297326492 0.391304347826087 11.2 11 2 lowered ear position 0.55645458026944 0.788482351706199 0.635386473429952 0.388888888888889 11.2 11 2 abnormal stomach glandular epithelium morphology 0.55645458026944 0.788482351706199 0.635386473429952 0.388888888888889 11.2 11 2 abnormal sperm axoneme morphology 0.55645458026944 0.788482351706199 0.635386473429952 0.388888888888889 11.2 11 2 abnormal CD8-positive, alpha beta T cell morphology 0.533752375745708 0.759609074170285 0.632458425165297 0.387096774193548 11.2 11 2 abnormal leukocyte adhesion 0.535040981605488 0.759609074170285 0.628404204491161 0.384615384615385 11.2 11 2 abnormal leukocyte migration 0.52307384438523 0.753632312718366 0.628404204491161 0.384615384615385 11.2 11 2 abnormal renal/urinary system morphology 0.588980278698998 0.800371825313034 0.628404204491161 0.384615384615385 11.2 11 2 small trigeminal ganglion 0.588980278698998 0.800371825313034 0.628404204491161 0.384615384615385 11.2 11 2 dystrophic cardiac calcinosis 0.588980278698998 0.800371825313034 0.628404204491161 0.384615384615385 11.2 11 2 abnormal GABAergic neuron morphology 0.588980278698998 0.800371825313034 0.628404204491161 0.384615384615385 11.2 11 2 muscle fatigue 0.588980278698998 0.800371825313034 0.628404204491161 0.384615384615385 11.2 11 2 vestibular hair cell degeneration 0.588980278698998 0.800371825313034 0.628404204491161 0.384615384615385 11.2 11 2 hyperalgesia 0.588980278698998 0.800371825313034 0.628404204491161 0.384615384615385 11.2 11 2 abnormal hair follicle inner root sheath morphology 0.588980278698998 0.800371825313034 0.628404204491161 0.384615384615385 11.2 11 2 decreased cardiac stroke volume 0.588980278698998 0.800371825313034 0.628404204491161 0.384615384615385 11.2 11 2 thin skin 0.551759221224859 0.782720879838516 0.624707709170625 0.382352941176471 11.2 11 2 abnormal bone remodeling 0.551759221224859 0.782720879838516 0.624707709170625 0.382352941176471 11.2 11 2 increased acute inflammation 0.577010641100578 0.800371825313034 0.622419402543626 0.380952380952381 11.2 11 2 decreased vocalization 0.577010641100578 0.800371825313034 0.622419402543626 0.380952380952381 11.2 11 2 increased susceptibility to parasitic infection 0.554541293209323 0.786443253624967 0.617232574189096 0.377777777777778 11.2 11 2 abnormal crypts of Lieberkuhn morphology 0.5878620906517 0.800371825313034 0.612694099378882 0.375 11.2 11 2 head bobbing 0.583508206119023 0.800371825313034 0.612694099378882 0.375 11.2 11 2 abnormal sensory capabilities/reflexes/nociception 0.595037319562836 0.800371825313034 0.612694099378882 0.375 11.2 11 2 small lymph nodes 0.595037319562836 0.800371825313034 0.612694099378882 0.375 11.2 11 2 decreased susceptibility to parasitic infection 0.5878620906517 0.800371825313034 0.612694099378882 0.375 11.2 11 2 decreased circulating growth hormone level 0.608344730094426 0.800371825313034 0.612694099378882 0.375 11.2 11 2 increased circulating estradiol level 0.608344730094426 0.800371825313034 0.612694099378882 0.375 11.2 11 2 abnormal pancreatic alpha cell morphology 0.608344730094426 0.800371825313034 0.612694099378882 0.375 11.2 11 2 abnormal cellular extravasation 0.595037319562836 0.800371825313034 0.612694099378882 0.375 11.2 11 2 dilated respiratory conducting tubes 0.608344730094426 0.800371825313034 0.612694099378882 0.375 11.2 11 2 enlarged adrenal glands 0.625020308283236 0.803193832030618 0.601945080091533 0.368421052631579 11.2 11 2 abnormal response to novelty 0.625020308283236 0.803193832030618 0.601945080091533 0.368421052631579 11.2 11 2 impaired natural killer cell mediated cytotoxicity 0.61842694460815 0.803193832030618 0.601945080091533 0.368421052631579 11.2 11 2 decreased IgA level 0.63487583327209 0.813000584434658 0.596983994266603 0.365384615384615 11.2 11 2 decreased airway responsiveness 0.639759813600282 0.814855810147679 0.594127611518916 0.363636363636364 11.2 11 2 impaired conditioned place preference behavior 0.653024892367179 0.828802788064003 0.588186335403727 0.36 11.2 11 2 abnormal zigzag hair morphology 0.665721038347522 0.842095643472902 0.58351818988465 0.357142857142857 11.2 11 2 increased aggression towards males 0.665721038347522 0.842095643472902 0.58351818988465 0.357142857142857 11.2 11 2 abnormal olfactory system physiology 0.665721038347522 0.842095643472902 0.58351818988465 0.357142857142857 11.2 11 2 abnormal spleen periarteriolar lymphoid sheath morphology 0.665721038347522 0.842095643472902 0.58351818988465 0.357142857142857 11.2 11 2 abnormal endplate potential 0.665721038347522 0.842095643472902 0.58351818988465 0.357142857142857 11.2 11 2 decreased coping response 0.665721038347522 0.842095643472902 0.58351818988465 0.357142857142857 11.2 11 2 abnormal prepulse inhibition 0.665721038347522 0.842095643472902 0.58351818988465 0.357142857142857 11.2 11 2 abnormal imprinting 0.665721038347522 0.842095643472902 0.58351818988465 0.357142857142857 11.2 11 2 abnormal positive T cell selection 0.665721038347522 0.842095643472902 0.58351818988465 0.357142857142857 11.2 11 2 abnormal tendon morphology 0.676841384372582 0.855944557003964 0.576653270003654 0.352941176470588 11.2 11 2 decreased susceptibility to induced arthritis 0.718042043636085 0.907586170500387 0.573281028658603 0.350877192982456 11.2 11 2 brain inflammation 0.6871836230658 0.868802674651171 0.571847826086957 0.35 11.2 11 2 abnormal diaphragm morphology 0.722564845066607 0.908338324296513 0.561636257763975 0.34375 11.2 11 2 abnormal action potential 0.774573341729455 0.928554789181696 0.560177462289263 0.342857142857143 11.2 11 2 abnormal inhibitory postsynaptic currents 0.795712893575509 0.950689636296388 0.552626050420168 0.338235294117647 11.2 11 2 eye inflammation 0.737034786424153 0.911899543014215 0.544616977225673 0.333333333333333 11.2 11 2 increased susceptibility to autoimmune disorder 0.737034786424153 0.911899543014215 0.544616977225673 0.333333333333333 11.2 11 2 decreased salivation 0.732366235365788 0.908338324296513 0.544616977225673 0.333333333333333 11.2 11 2 increased alcohol consumption 0.732366235365788 0.908338324296513 0.544616977225673 0.333333333333333 11.2 11 2 greasy coat 0.732366235365788 0.908338324296513 0.544616977225673 0.333333333333333 11.2 11 2 abnormal neurotransmitter secretion 0.732366235365788 0.908338324296513 0.544616977225673 0.333333333333333 11.2 11 2 lactation failure 0.732366235365788 0.908338324296513 0.544616977225673 0.333333333333333 11.2 11 2 hypoalgesia 0.742270114048412 0.912870785642529 0.544616977225673 0.333333333333333 11.2 11 2 decreased cytotoxic T cell cytolysis 0.801523377010441 0.955108694760945 0.528598830836683 0.323529411764706 11.2 11 2 abnormal body temperature homeostasis 0.798202024715769 0.951378790838752 0.527048687637748 0.32258064516129 11.2 11 2 decreased acute inflammation 0.792333501218327 0.946879454374532 0.522832298136646 0.32 11.2 11 2 increased activated T cell number 0.790108254257539 0.945619731482724 0.519861660079051 0.318181818181818 11.2 11 2 abnormal nail morphology 0.788733776335345 0.944626803825839 0.515952925792743 0.315789473684211 11.2 11 2 bowed tibia 0.788739646852771 0.944626803825839 0.510578416149068 0.3125 11.2 11 2 abnormal wound healing 0.788739646852771 0.944626803825839 0.510578416149068 0.3125 11.2 11 2 abnormal fertilization 0.788739646852771 0.944626803825839 0.510578416149068 0.3125 11.2 11 2 increased susceptibility to induced arthritis 0.831376074318586 0.985488675181074 0.507057185692868 0.310344827586207 11.2 11 2 increased susceptibility to age related obesity 0.83090920536306 0.985169994442618 0.497258979206049 0.304347826086957 11.2 11 2 increased susceptibility to fungal infection 0.83090920536306 0.985169994442618 0.497258979206049 0.304347826086957 11.2 11 2 abnormal thymocyte activation 0.832255270593721 0.986295848309614 0.490155279503106 0.3 11.2 11 2 abnormal estrous cycle 0.862451761680064 1 0.490155279503106 0.3 11.2 11 2 abnormal synaptic transmission 0.862451761680064 1 0.490155279503106 0.3 11.2 11 2 increased aggression towards mice 0.835363922886182 0.988894347612323 0.480544391669711 0.294117647058824 11.2 11 2 decreased growth hormone level 0.835363922886182 0.988894347612323 0.480544391669711 0.294117647058824 11.2 11 2 abnormal stomach mucosa morphology 0.893466522729778 1 0.457478260869565 0.28 11.2 11 2 blepharoptosis 0.873182821525425 1 0.453847481021394 0.277777777777778 11.2 11 2 abnormal retinal cone cell morphology 0.921073308098527 1 0.426221982176614 0.260869565217391 11.2 11 2 abnormal regulatory T cell physiology 0.921073308098527 1 0.426221982176614 0.260869565217391 11.2 11 2 abnormal single cell response 0.935211182456367 1 0.423590982286634 0.259259259259259 11.2 11 2 abnormal channel response 0.959487097982231 1 0.371329757199322 0.227272727272727 11.2 11 2 embryonic lethality between implantation and placentation, incomplete penetrance 5.72415429142659e-06 0.000114829304838094 1.73360193392425 1 11.3 11 3 decreased cardiomyocyte apoptosis 0.000875763646027244 0.00839484419843071 1.73360193392425 1 11.3 11 3 abnormal thyroid hormone level 0.000875763646027244 0.00839484419843071 1.73360193392425 1 11.3 11 3 abnormal renal filtration rate 0.000875763646027244 0.00839484419843071 1.73360193392425 1 11.3 11 3 abnormal retina inner limiting membrane morphology 0.000875763646027244 0.00839484419843071 1.73360193392425 1 11.3 11 3 ductus venosus stenosis 0.000875763646027244 0.00839484419843071 1.73360193392425 1 11.3 11 3 thin tail 0.00239472358480749 0.0194669114941458 1.73360193392425 1 11.3 11 3 abnormal lacrimal gland physiology 0.00239472358480749 0.0194669114941458 1.73360193392425 1 11.3 11 3 absent ectoplacental cone 0.00239472358480749 0.0194669114941458 1.73360193392425 1 11.3 11 3 abnormal hippocampal fimbria morphology 0.00239472358480749 0.0194669114941458 1.73360193392425 1 11.3 11 3 bile duct inflammation 0.00239472358480749 0.0194669114941458 1.73360193392425 1 11.3 11 3 increased triiodothyronine level 0.00239472358480749 0.0194669114941458 1.73360193392425 1 11.3 11 3 aminoaciduria 3.73663096234353e-08 1.27326979709994e-06 1.73360193392425 1 11.3 11 3 abnormal plasma membrane morphology 4.28201527273883e-05 0.000643595951114068 1.73360193392425 1 11.3 11 3 abnormal kidney epithelium morphology 0.000320255226042277 0.00367960681191761 1.73360193392425 1 11.3 11 3 abnormal cerebellum deep nucleus morphology 0.000320255226042277 0.00367960681191761 1.73360193392425 1 11.3 11 3 abnormal tooth eruption 0.00654789433882185 0.0428203811863781 1.73360193392425 1 11.3 11 3 absent lungs 0.00654789433882185 0.0428203811863781 1.73360193392425 1 11.3 11 3 increased urine microalbumin level 0.00654789433882185 0.0428203811863781 1.73360193392425 1 11.3 11 3 increased lysosomal enzyme secretion 0.00654789433882185 0.0428203811863781 1.73360193392425 1 11.3 11 3 bile duct proliferation 0.00654789433882185 0.0428203811863781 1.73360193392425 1 11.3 11 3 gastric polyps 0.00654789433882185 0.0428203811863781 1.73360193392425 1 11.3 11 3 premature endochondral bone ossification 0.00654789433882185 0.0428203811863781 1.73360193392425 1 11.3 11 3 increased heart right ventricle weight 0.00654789433882185 0.0428203811863781 1.73360193392425 1 11.3 11 3 hemolysis 0.00654789433882185 0.0428203811863781 1.73360193392425 1 11.3 11 3 increased response to stress-induced hyperthermia 0.00654789433882185 0.0428203811863781 1.73360193392425 1 11.3 11 3 leptocytosis 0.00654789433882185 0.0428203811863781 1.73360193392425 1 11.3 11 3 aorta hypoplasia 0.00654789433882185 0.0428203811863781 1.73360193392425 1 11.3 11 3 enlarged aortic valve 0.00654789433882185 0.0428203811863781 1.73360193392425 1 11.3 11 3 abnormal paranode morphology 0.00654789433882185 0.0428203811863781 1.73360193392425 1 11.3 11 3 pale lung 0.00654789433882185 0.0428203811863781 1.73360193392425 1 11.3 11 3 abnormal lung alveolus development 0.00654789433882185 0.0428203811863781 1.73360193392425 1 11.3 11 3 cystinuria 0.00654789433882185 0.0428203811863781 1.73360193392425 1 11.3 11 3 increased liver adenoma incidence 1.69642939255719e-07 4.87846024738266e-06 1.64235972687561 0.947368421052632 11.3 11 3 testis degeneration 1.93524218723591e-05 0.000329720201421186 1.60977322435824 0.928571428571429 11.3 11 3 multiple persisting craniopharyngeal ducts 1.93524218723591e-05 0.000329720201421186 1.60977322435824 0.928571428571429 11.3 11 3 decreased red blood cell distribution width 0.00012491065845378 0.00164399610001999 1.58913510609723 0.916666666666667 11.3 11 3 abnormal thrombopoiesis 0.000314458050285043 0.00362976519760577 1.57600175811296 0.909090909090909 11.3 11 3 delayed hepatic development 0.000314458050285043 0.00362976519760577 1.57600175811296 0.909090909090909 11.3 11 3 abnormal eye distance/ position 0.000314458050285043 0.00362976519760577 1.57600175811296 0.909090909090909 11.3 11 3 fatigue 0.000314458050285043 0.00362976519760577 1.57600175811296 0.909090909090909 11.3 11 3 pharyngeal arch hypoplasia 0.000314458050285043 0.00362976519760577 1.57600175811296 0.909090909090909 11.3 11 3 common atrioventricular valve 0.000314458050285043 0.00362976519760577 1.57600175811296 0.909090909090909 11.3 11 3 reduced sympathetic cervical ganglion size 0.000314458050285043 0.00362976519760577 1.57600175811296 0.909090909090909 11.3 11 3 absent ductus venosus valve 1.1098970418515e-06 2.69353062595668e-05 1.56024174053183 0.9 11.3 11 3 abnormal mammary gland physiology 0.000785689893697496 0.00778646856801801 1.56024174053183 0.9 11.3 11 3 decreased transitional stage T2 B cell number 0.000785689893697496 0.00778646856801801 1.56024174053183 0.9 11.3 11 3 abnormal inferior vena cava valve morphology 0.000785689893697496 0.00778646856801801 1.56024174053183 0.9 11.3 11 3 decreased cellular sensitivity to gamma-irradiation 6.73682704203645e-06 0.000131434174643652 1.54097949682156 0.888888888888889 11.3 11 3 dilated uterus 0.0019454400197853 0.0166298352206733 1.54097949682156 0.888888888888889 11.3 11 3 pancreas cysts 0.0019454400197853 0.0166298352206733 1.54097949682156 0.888888888888889 11.3 11 3 liver hyperplasia 0.0019454400197853 0.0166298352206733 1.54097949682156 0.888888888888889 11.3 11 3 positive geotaxis 0.0019454400197853 0.0166298352206733 1.54097949682156 0.888888888888889 11.3 11 3 decreased transitional stage T1 B cell number 0.0019454400197853 0.0166298352206733 1.54097949682156 0.888888888888889 11.3 11 3 abnormal infrahyoid muscle connection 0.0019454400197853 0.0166298352206733 1.54097949682156 0.888888888888889 11.3 11 3 impaired somite development 3.98939292819083e-05 0.000612568821535474 1.51690169218372 0.875 11.3 11 3 early eyelid opening 0.00476432258592201 0.0335254665699604 1.51690169218372 0.875 11.3 11 3 colon polyps 0.00476432258592201 0.0335254665699604 1.51690169218372 0.875 11.3 11 3 liver cysts 0.00476432258592201 0.0335254665699604 1.51690169218372 0.875 11.3 11 3 elevated level of mitotic sister chromatid exchange 0.00476432258592201 0.0335254665699604 1.51690169218372 0.875 11.3 11 3 binucleate 0.00476432258592201 0.0335254665699604 1.51690169218372 0.875 11.3 11 3 abnormal extraembryonic tissue physiology 0.00476432258592201 0.0335254665699604 1.51690169218372 0.875 11.3 11 3 ocular hypertension 0.00476432258592201 0.0335254665699604 1.51690169218372 0.875 11.3 11 3 craniofacial phenotype 0.00476432258592201 0.0335254665699604 1.51690169218372 0.875 11.3 11 3 stomach epithelial hyperplasia 0.00476432258592201 0.0335254665699604 1.51690169218372 0.875 11.3 11 3 abnormal pulmonary acinus morphology 0.00476432258592201 0.0335254665699604 1.51690169218372 0.875 11.3 11 3 abnormal foramen magnum morphology 0.00476432258592201 0.0335254665699604 1.51690169218372 0.875 11.3 11 3 increased circulating ferritin level 0.00476432258592201 0.0335254665699604 1.51690169218372 0.875 11.3 11 3 increased circulating lactate level 0.00476432258592201 0.0335254665699604 1.51690169218372 0.875 11.3 11 3 increased brain apoptosis 0.00476432258592201 0.0335254665699604 1.51690169218372 0.875 11.3 11 3 decreased basal metabolism 0.00476432258592201 0.0335254665699604 1.51690169218372 0.875 11.3 11 3 subcutaneous edema 1.18657146171194e-07 3.55614037470898e-06 1.48594451479222 0.857142857142857 11.3 11 3 abnormal blood flow velocity 0.000228995662740816 0.00280073683403888 1.48594451479222 0.857142857142857 11.3 11 3 irregularly shaped pupil 0.000228995662740816 0.00280073683403888 1.48594451479222 0.857142857142857 11.3 11 3 failure of atrioventricular cushion closure 0.0115084832174889 0.0646945807988785 1.48594451479222 0.857142857142857 11.3 11 3 skin photosensitivity 0.0115084832174889 0.0646945807988785 1.48594451479222 0.857142857142857 11.3 11 3 abnormal lacrimal gland morphology 0.0115084832174889 0.0646945807988785 1.48594451479222 0.857142857142857 11.3 11 3 abnormal axial mesoderm 0.0115084832174889 0.0646945807988785 1.48594451479222 0.857142857142857 11.3 11 3 abnormal gastrulation movements 0.0115084832174889 0.0646945807988785 1.48594451479222 0.857142857142857 11.3 11 3 abnormal brain ventricular system morphology 0.0115084832174889 0.0646945807988785 1.48594451479222 0.857142857142857 11.3 11 3 decreased mortality induced by ionizing radiation 0.0115084832174889 0.0646945807988785 1.48594451479222 0.857142857142857 11.3 11 3 abnormal talus morphology 0.0115084832174889 0.0646945807988785 1.48594451479222 0.857142857142857 11.3 11 3 urolithiasis 0.0115084832174889 0.0646945807988785 1.48594451479222 0.857142857142857 11.3 11 3 decreased tidal volume 0.0115084832174889 0.0646945807988785 1.48594451479222 0.857142857142857 11.3 11 3 uremia 0.0115084832174889 0.0646945807988785 1.48594451479222 0.857142857142857 11.3 11 3 arteritis 0.0115084832174889 0.0646945807988785 1.48594451479222 0.857142857142857 11.3 11 3 decreased brain cholesterol level 0.0115084832174889 0.0646945807988785 1.48594451479222 0.857142857142857 11.3 11 3 abnormal conotruncal ridge morphology 0.0115084832174889 0.0646945807988785 1.48594451479222 0.857142857142857 11.3 11 3 increased compact bone volume 0.0115084832174889 0.0646945807988785 1.48594451479222 0.857142857142857 11.3 11 3 impaired branching involved in bronchus morphogenesis 0.0115084832174889 0.0646945807988785 1.48594451479222 0.857142857142857 11.3 11 3 decreased CD8-positive, naive alpha-beta T cell number 0.0115084832174889 0.0646945807988785 1.48594451479222 0.857142857142857 11.3 11 3 decreased circulating fructosamine level 2.79431118991102e-07 7.68049622641289e-06 1.47677201778733 0.851851851851852 11.3 11 3 abnormal Mullerian duct morphology 6.54179600806115e-07 1.6689966738515e-05 1.46689394408975 0.846153846153846 11.3 11 3 tracheoesophageal fistula 0.000540761270397811 0.00572948788917116 1.46689394408975 0.846153846153846 11.3 11 3 increased fibroblast apoptosis 3.65572617477336e-08 1.2569797035825e-06 1.46272663174859 0.84375 11.3 11 3 embryonic lethality between implantation and somite formation, incomplete penetrance 2.80425306864602e-05 0.000451493819304658 1.45987531277832 0.842105263157895 11.3 11 3 absent inner cell mass 6.50176812387148e-05 0.000943040711844333 1.44466827827021 0.833333333333333 11.3 11 3 dilated bile duct 0.00126219500944136 0.011500769545734 1.44466827827021 0.833333333333333 11.3 11 3 absent ovary 0.00126219500944136 0.011500769545734 1.44466827827021 0.833333333333333 11.3 11 3 pale placenta 0.00126219500944136 0.011500769545734 1.44466827827021 0.833333333333333 11.3 11 3 abnormal pulmonary valve cusp morphology 0.00126219500944136 0.011500769545734 1.44466827827021 0.833333333333333 11.3 11 3 echinocytosis 0.0273137481088937 0.124895125773664 1.44466827827021 0.833333333333333 11.3 11 3 delayed brain development 0.0273137481088937 0.124895125773664 1.44466827827021 0.833333333333333 11.3 11 3 abnormal parental behavior 0.0273137481088937 0.124895125773664 1.44466827827021 0.833333333333333 11.3 11 3 abnormal hepatobiliary system physiology 0.0273137481088937 0.124895125773664 1.44466827827021 0.833333333333333 11.3 11 3 liver cirrhosis 0.0273137481088937 0.124895125773664 1.44466827827021 0.833333333333333 11.3 11 3 loss of hippocampal neurons 0.0273137481088937 0.124895125773664 1.44466827827021 0.833333333333333 11.3 11 3 esophageal atresia 0.0273137481088937 0.124895125773664 1.44466827827021 0.833333333333333 11.3 11 3 enlarged pancreas 0.0273137481088937 0.124895125773664 1.44466827827021 0.833333333333333 11.3 11 3 abnormal leukocyte tethering or rolling 0.0273137481088937 0.124895125773664 1.44466827827021 0.833333333333333 11.3 11 3 abnormal heart left atrium morphology 0.0273137481088937 0.124895125773664 1.44466827827021 0.833333333333333 11.3 11 3 absent parietal bone 0.0273137481088937 0.124895125773664 1.44466827827021 0.833333333333333 11.3 11 3 decreased prostate gland weight 0.0273137481088937 0.124895125773664 1.44466827827021 0.833333333333333 11.3 11 3 abnormal blastocoele morphology 0.0273137481088937 0.124895125773664 1.44466827827021 0.833333333333333 11.3 11 3 abnormal eyelid development 0.0273137481088937 0.124895125773664 1.44466827827021 0.833333333333333 11.3 11 3 absent sperm mitochondrial sheath 0.0273137481088937 0.124895125773664 1.44466827827021 0.833333333333333 11.3 11 3 abnormal olfactory bulb layer morphology 0.0273137481088937 0.124895125773664 1.44466827827021 0.833333333333333 11.3 11 3 increased erythrocyte clearance 0.0273137481088937 0.124895125773664 1.44466827827021 0.833333333333333 11.3 11 3 myocardium hypoplasia 0.0273137481088937 0.124895125773664 1.44466827827021 0.833333333333333 11.3 11 3 abnormal intestinal enteroendocrine cell morphology 0.0273137481088937 0.124895125773664 1.44466827827021 0.833333333333333 11.3 11 3 delayed limb development 0.0273137481088937 0.124895125773664 1.44466827827021 0.833333333333333 11.3 11 3 abnormal Rathke's pouch development 0.0273137481088937 0.124895125773664 1.44466827827021 0.833333333333333 11.3 11 3 ciliary body hypoplasia 0.0273137481088937 0.124895125773664 1.44466827827021 0.833333333333333 11.3 11 3 additional anastomosis between intracranial vertebral arteries 0.0273137481088937 0.124895125773664 1.44466827827021 0.833333333333333 11.3 11 3 abnormal platelet alpha-granule morphology 0.0273137481088937 0.124895125773664 1.44466827827021 0.833333333333333 11.3 11 3 decreased capillary density 0.0273137481088937 0.124895125773664 1.44466827827021 0.833333333333333 11.3 11 3 increased cardiac cell glucose uptake 0.0273137481088937 0.124895125773664 1.44466827827021 0.833333333333333 11.3 11 3 blood in lymph vessels 4.47676509145972e-07 1.16606839424147e-05 1.4347050487649 0.827586206896552 11.3 11 3 abnormal Wolffian duct morphology 8.06182746428246e-06 0.000150780419679719 1.43210594541569 0.826086956521739 11.3 11 3 abnormal interatrial septum morphology 0.000149297519803894 0.00189962956783726 1.4276721808788 0.823529411764706 11.3 11 3 abnormal head morphology 7.50866879369987e-12 4.6694534060821e-10 1.41840158230166 0.818181818181818 11.3 11 3 embryonic lethality before implantation, incomplete penetrance 1.83356218193873e-05 0.000316735133859208 1.41840158230166 0.818181818181818 11.3 11 3 premature suture closure 0.00290623318905354 0.0223815946061012 1.41840158230166 0.818181818181818 11.3 11 3 loss of cortex neurons 0.00290623318905354 0.0223815946061012 1.41840158230166 0.818181818181818 11.3 11 3 abnormal dorsal-ventral polarity of the somites 0.00290623318905354 0.0223815946061012 1.41840158230166 0.818181818181818 11.3 11 3 abnormal palate development 0.00290623318905354 0.0223815946061012 1.41840158230166 0.818181818181818 11.3 11 3 palatal shelf hypoplasia 0.00290623318905354 0.0223815946061012 1.41840158230166 0.818181818181818 11.3 11 3 abnormal brain ependyma motile cilium morphology 0.00290623318905354 0.0223815946061012 1.41840158230166 0.818181818181818 11.3 11 3 abnormal eye muscle morphology 2.30307292079217e-06 5.04748360393878e-05 1.4125645387531 0.814814814814815 11.3 11 3 absent mandible 0.000339132208496192 0.00386968517722145 1.40855157131346 0.8125 11.3 11 3 liver degeneration 4.13304178995855e-05 0.000623800795511133 1.40339204174821 0.80952380952381 11.3 11 3 liver fibrosis 1.09344410163352e-08 4.12112454971723e-07 1.39533814193903 0.804878048780488 11.3 11 3 embryonic lethality between implantation and placentation, complete penetrance 1.42638382945347e-09 6.06517910387265e-08 1.39441894685212 0.804347826086957 11.3 11 3 liver hemorrhage 1.45681968104209e-06 3.40384444454383e-05 1.3868815471394 0.8 11.3 11 3 vagina atresia 0.000760973887165737 0.00763275219485795 1.3868815471394 0.8 11.3 11 3 abnormal placenta size 0.000760973887165737 0.00763275219485795 1.3868815471394 0.8 11.3 11 3 immune system phenotype 0.000760973887165737 0.00763275219485795 1.3868815471394 0.8 11.3 11 3 heterochrony 0.000760973887165737 0.00763275219485795 1.3868815471394 0.8 11.3 11 3 increased mammary adenocarcinoma incidence 9.22501168154142e-05 0.00125394625999094 1.3868815471394 0.8 11.3 11 3 increased skin tumor incidence 9.22501168154142e-05 0.00125394625999094 1.3868815471394 0.8 11.3 11 3 fused cornea and lens 0.00658444052413653 0.0428203811863781 1.3868815471394 0.8 11.3 11 3 decreased incidence of induced tumors 0.00658444052413653 0.0428203811863781 1.3868815471394 0.8 11.3 11 3 abnormal respiratory mechanics 0.00658444052413653 0.0428203811863781 1.3868815471394 0.8 11.3 11 3 ketoaciduria 0.00658444052413653 0.0428203811863781 1.3868815471394 0.8 11.3 11 3 impaired basement membrane formation 0.00658444052413653 0.0428203811863781 1.3868815471394 0.8 11.3 11 3 acrania 0.00658444052413653 0.0428203811863781 1.3868815471394 0.8 11.3 11 3 bifid ureter 0.00658444052413653 0.0428203811863781 1.3868815471394 0.8 11.3 11 3 absent seminal vesicle 0.00658444052413653 0.0428203811863781 1.3868815471394 0.8 11.3 11 3 abnormal hindlimb zeugopod morphology 0.00658444052413653 0.0428203811863781 1.3868815471394 0.8 11.3 11 3 vascular smooth muscle hyperplasia 0.00658444052413653 0.0428203811863781 1.3868815471394 0.8 11.3 11 3 crystalluria 0.00658444052413653 0.0428203811863781 1.3868815471394 0.8 11.3 11 3 abnormal spinal cord dorsal column morphology 0.00658444052413653 0.0428203811863781 1.3868815471394 0.8 11.3 11 3 abnormal hippocampus neuron morphology 0.00658444052413653 0.0428203811863781 1.3868815471394 0.8 11.3 11 3 acanthocytosis 0.00658444052413653 0.0428203811863781 1.3868815471394 0.8 11.3 11 3 fusion of atlas and odontoid process 0.00658444052413653 0.0428203811863781 1.3868815471394 0.8 11.3 11 3 abnormal adaptive thermogenesis 0.00658444052413653 0.0428203811863781 1.3868815471394 0.8 11.3 11 3 lethality during fetal growth through weaning, complete penetrance 0.00658444052413653 0.0428203811863781 1.3868815471394 0.8 11.3 11 3 abnormal amino acid level 6.93796614469278e-09 2.71782532046036e-07 1.37900153834884 0.795454545454545 11.3 11 3 increased hepatocyte apoptosis 5.32512911305096e-08 1.73153708087768e-06 1.37799128081159 0.794871794871795 11.3 11 3 abnormal blastocyst morphology 0.00020367449580967 0.00254315620150318 1.36863310572967 0.789473684210526 11.3 11 3 decreased liver regeneration 0.00020367449580967 0.00254315620150318 1.36863310572967 0.789473684210526 11.3 11 3 embryonic lethality between somite formation and embryo turning, complete penetrance 8.30257823893475e-13 6.16497414010454e-11 1.3621158052262 0.785714285714286 11.3 11 3 lymphoid hyperplasia 7.01137185250027e-06 0.000135199902969724 1.3621158052262 0.785714285714286 11.3 11 3 premature aging 7.01137185250027e-06 0.000135199902969724 1.3621158052262 0.785714285714286 11.3 11 3 abnormal maternal decidual layer morphology 0.00168390183180679 0.0146714739286143 1.3621158052262 0.785714285714286 11.3 11 3 split sternum 0.00168390183180679 0.0146714739286143 1.3621158052262 0.785714285714286 11.3 11 3 abnormal renal tubule epithelial cell primary cilium morphology 0.00168390183180679 0.0146714739286143 1.3621158052262 0.785714285714286 11.3 11 3 abnormal vitelline vein topology 0.00168390183180679 0.0146714739286143 1.3621158052262 0.785714285714286 11.3 11 3 failure to gastrulate 9.37372751014298e-09 3.58725341253549e-07 1.35673194828855 0.782608695652174 11.3 11 3 increased embryonic tissue cell apoptosis 6.90493010962945e-14 6.60615909527048e-12 1.35576561499205 0.782051282051282 11.3 11 3 abnormal bile duct morphology 0.000444276954782019 0.00476352984922531 1.34835705971886 0.777777777777778 11.3 11 3 abnormal body wall morphology 0.000444276954782019 0.00476352984922531 1.34835705971886 0.777777777777778 11.3 11 3 abnormal anterior eye segment morphology 0.000444276954782019 0.00476352984922531 1.34835705971886 0.777777777777778 11.3 11 3 abnormal aerobic respiration 0.000444276954782019 0.00476352984922531 1.34835705971886 0.777777777777778 11.3 11 3 abnormal hypoglossal nerve topology 0.000444276954782019 0.00476352984922531 1.34835705971886 0.777777777777778 11.3 11 3 abnormal ion homeostasis 0.0146304115674005 0.0792016295406067 1.34835705971886 0.777777777777778 11.3 11 3 short frontal bone 0.0146304115674005 0.0792016295406067 1.34835705971886 0.777777777777778 11.3 11 3 eye opacity 0.0146304115674005 0.0792016295406067 1.34835705971886 0.777777777777778 11.3 11 3 abnormal pulmonary alveolar system morphology 0.0146304115674005 0.0792016295406067 1.34835705971886 0.777777777777778 11.3 11 3 trigeminal neuroma 0.0146304115674005 0.0792016295406067 1.34835705971886 0.777777777777778 11.3 11 3 symmetric azygos veins 0.0146304115674005 0.0792016295406067 1.34835705971886 0.777777777777778 11.3 11 3 decreased fatty acid oxidation 0.0146304115674005 0.0792016295406067 1.34835705971886 0.777777777777778 11.3 11 3 cerebellum atrophy 0.0146304115674005 0.0792016295406067 1.34835705971886 0.777777777777778 11.3 11 3 increased endoplasmic reticulum stress 0.0146304115674005 0.0792016295406067 1.34835705971886 0.777777777777778 11.3 11 3 abnormal mesoderm development 1.62361081102076e-09 6.84530829222734e-08 1.34108828850744 0.773584905660377 11.3 11 3 abnormal germ layer development 0.00011951272457226 0.00159403701004556 1.33960149439601 0.772727272727273 11.3 11 3 kidney cysts 1.44279302268651e-12 1.04027467940078e-10 1.3353420301849 0.77027027027027 11.3 11 3 liver hypoplasia 3.45503408225673e-09 1.3974629722949e-07 1.3335399491725 0.769230769230769 11.3 11 3 decreased circulating glycerol level 3.25781950073213e-05 0.00051290038025767 1.3335399491725 0.769230769230769 11.3 11 3 increased circulating thyroxine level 0.00366697413958651 0.0278097505250654 1.3335399491725 0.769230769230769 11.3 11 3 absent hypoglossal nerve 0.00366697413958651 0.0278097505250654 1.3335399491725 0.769230769230769 11.3 11 3 abnormal gastrulation 7.3123162523012e-09 2.84209166837488e-07 1.32569559653031 0.764705882352941 11.3 11 3 abnormal testis development 0.000956094946746163 0.0090947846272699 1.32569559653031 0.764705882352941 11.3 11 3 abnormal ductus venosus valve morphology 0.000956094946746163 0.0090947846272699 1.32569559653031 0.764705882352941 11.3 11 3 abnormal erythropoiesis 1.38633345042035e-16 1.97057397595464e-14 1.32083956870419 0.761904761904762 11.3 11 3 abnormal embryonic/fetal subventricular zone morphology 0.000255193153346065 0.00302282366165875 1.32083956870419 0.761904761904762 11.3 11 3 vascular ring 0.000255193153346065 0.00302282366165875 1.32083956870419 0.761904761904762 11.3 11 3 embryonic lethality at implantation, complete penetrance 0.000255193153346065 0.00302282366165875 1.32083956870419 0.761904761904762 11.3 11 3 absent segment of posterior cerebral artery 0.000255193153346065 0.00302282366165875 1.32083956870419 0.761904761904762 11.3 11 3 increased muscle cell glucose uptake 0.000255193153346065 0.00302282366165875 1.32083956870419 0.761904761904762 11.3 11 3 corneal opacity 1.35402719304259e-11 8.01938724450817e-10 1.31851414692831 0.76056338028169 11.3 11 3 abnormal egg cylinder morphology 6.91795916047482e-05 0.000997589762996007 1.31753746978243 0.76 11.3 11 3 increased mortality induced by gamma-irradiation 1.89615834908268e-05 0.000325289234023666 1.31514629470116 0.758620689655172 11.3 11 3 malocclusion 1.45732435515143e-06 3.40384444454383e-05 1.31191497702376 0.756756756756757 11.3 11 3 anophthalmia 1.11788649837167e-13 1.01117915079983e-11 1.30507111879691 0.752808988764045 11.3 11 3 abnormal mineral level 0.00783834772789007 0.0491750062373935 1.30020145044319 0.75 11.3 11 3 amyloidosis 0.00783834772789007 0.0491750062373935 1.30020145044319 0.75 11.3 11 3 interstitial pneumonia 0.00783834772789007 0.0491750062373935 1.30020145044319 0.75 11.3 11 3 abnormal embryonic growth/weight/body size 0.00783834772789007 0.0491750062373935 1.30020145044319 0.75 11.3 11 3 increased osteosarcoma incidence 0.00783834772789007 0.0491750062373935 1.30020145044319 0.75 11.3 11 3 delayed somite formation 0.00783834772789007 0.0491750062373935 1.30020145044319 0.75 11.3 11 3 decreased left ventricle systolic pressure 0.00783834772789007 0.0491750062373935 1.30020145044319 0.75 11.3 11 3 abnormal rostral-caudal body axis extension 0.00783834772789007 0.0491750062373935 1.30020145044319 0.75 11.3 11 3 increased hepatocyte proliferation 0.00783834772789007 0.0491750062373935 1.30020145044319 0.75 11.3 11 3 hemoperitoneum 0.00783834772789007 0.0491750062373935 1.30020145044319 0.75 11.3 11 3 prenatal growth retardation 0.00783834772789007 0.0491750062373935 1.30020145044319 0.75 11.3 11 3 abnormal vitelline vein connection 0.00783834772789007 0.0491750062373935 1.30020145044319 0.75 11.3 11 3 decreased mean corpuscular hemoglobin 1.22281208570201e-10 6.27163930553351e-09 1.30020145044319 0.75 11.3 11 3 abnormal brainstem morphology 3.97068576619049e-05 0.000611583953151631 1.30020145044319 0.75 11.3 11 3 increased triglyceride level 3.97068576619049e-05 0.000611583953151631 1.30020145044319 0.75 11.3 11 3 anencephaly 0.000537947632792437 0.00571856725030422 1.30020145044319 0.75 11.3 11 3 abnormal optic stalk morphology 0.000537947632792437 0.00571856725030422 1.30020145044319 0.75 11.3 11 3 dilated vasculature 0.000537947632792437 0.00571856725030422 1.30020145044319 0.75 11.3 11 3 abnormal neuron proliferation 0.000537947632792437 0.00571856725030422 1.30020145044319 0.75 11.3 11 3 decreased creatinine clearance 0.00202649892317437 0.01720449171125 1.30020145044319 0.75 11.3 11 3 increased heart left ventricle size 0.00202649892317437 0.01720449171125 1.30020145044319 0.75 11.3 11 3 decreased midbrain size 0.00202649892317437 0.01720449171125 1.30020145044319 0.75 11.3 11 3 failure of vascular branching 0.0317409651121898 0.135198032048925 1.30020145044319 0.75 11.3 11 3 abnormal esophageal epithelium morphology 0.0317409651121898 0.135198032048925 1.30020145044319 0.75 11.3 11 3 abnormal cecum morphology 0.0317409651121898 0.135198032048925 1.30020145044319 0.75 11.3 11 3 clubfoot 0.0317409651121898 0.135198032048925 1.30020145044319 0.75 11.3 11 3 enlarged pituitary gland 0.0317409651121898 0.135198032048925 1.30020145044319 0.75 11.3 11 3 abnormal pupil morphology 0.0317409651121898 0.135198032048925 1.30020145044319 0.75 11.3 11 3 abnormal urination 0.0317409651121898 0.135198032048925 1.30020145044319 0.75 11.3 11 3 abnormal atrial thrombosis 0.0317409651121898 0.135198032048925 1.30020145044319 0.75 11.3 11 3 abnormal hepatobiliary system morphology 0.0317409651121898 0.135198032048925 1.30020145044319 0.75 11.3 11 3 abnormal secondary sex determination 0.0317409651121898 0.135198032048925 1.30020145044319 0.75 11.3 11 3 abnormal pulmonary circulation 0.0317409651121898 0.135198032048925 1.30020145044319 0.75 11.3 11 3 coarse hair 0.0317409651121898 0.135198032048925 1.30020145044319 0.75 11.3 11 3 abnormal thyroid physiology 0.0317409651121898 0.135198032048925 1.30020145044319 0.75 11.3 11 3 hypospadia 0.0317409651121898 0.135198032048925 1.30020145044319 0.75 11.3 11 3 abnormal cellular cholesterol metabolism 0.0317409651121898 0.135198032048925 1.30020145044319 0.75 11.3 11 3 calcified muscle 0.0317409651121898 0.135198032048925 1.30020145044319 0.75 11.3 11 3 abnormal platelet shape 0.0317409651121898 0.135198032048925 1.30020145044319 0.75 11.3 11 3 abnormal forelimb zeugopod morphology 0.0317409651121898 0.135198032048925 1.30020145044319 0.75 11.3 11 3 lymph node inflammation 0.0317409651121898 0.135198032048925 1.30020145044319 0.75 11.3 11 3 tau protein deposits 0.0317409651121898 0.135198032048925 1.30020145044319 0.75 11.3 11 3 absent interparietal bone 0.0317409651121898 0.135198032048925 1.30020145044319 0.75 11.3 11 3 abnormal choroid pigmentation 0.0317409651121898 0.135198032048925 1.30020145044319 0.75 11.3 11 3 Sertoli cell hypoplasia 0.0317409651121898 0.135198032048925 1.30020145044319 0.75 11.3 11 3 abnormal base-excision repair 0.0317409651121898 0.135198032048925 1.30020145044319 0.75 11.3 11 3 abnormal sphingomyelin level 0.0317409651121898 0.135198032048925 1.30020145044319 0.75 11.3 11 3 abnormal olfactory bulb mitral cell layer morphology 0.0317409651121898 0.135198032048925 1.30020145044319 0.75 11.3 11 3 increased caudal vertebrae number 0.0317409651121898 0.135198032048925 1.30020145044319 0.75 11.3 11 3 abnormal lateral plate mesoderm morphology 0.0317409651121898 0.135198032048925 1.30020145044319 0.75 11.3 11 3 decreased quadriceps weight 0.0317409651121898 0.135198032048925 1.30020145044319 0.75 11.3 11 3 pleural effusion 0.0317409651121898 0.135198032048925 1.30020145044319 0.75 11.3 11 3 heart right ventricle hypoplasia 0.0317409651121898 0.135198032048925 1.30020145044319 0.75 11.3 11 3 abnormal hepatic vein morphology 0.0317409651121898 0.135198032048925 1.30020145044319 0.75 11.3 11 3 anomalous pulmonary venous connection 0.0317409651121898 0.135198032048925 1.30020145044319 0.75 11.3 11 3 increased heart right ventricle size 0.0317409651121898 0.135198032048925 1.30020145044319 0.75 11.3 11 3 abnormal stomach position or orientation 0.0317409651121898 0.135198032048925 1.30020145044319 0.75 11.3 11 3 lung situs inversus 0.0317409651121898 0.135198032048925 1.30020145044319 0.75 11.3 11 3 decreased alveolar lamellar body number 0.0317409651121898 0.135198032048925 1.30020145044319 0.75 11.3 11 3 abnormal bronchiole epithelium morphology 0.0317409651121898 0.135198032048925 1.30020145044319 0.75 11.3 11 3 abnormal macrophage activation involved in immune response 0.0317409651121898 0.135198032048925 1.30020145044319 0.75 11.3 11 3 absent Reichert's membrane 0.0317409651121898 0.135198032048925 1.30020145044319 0.75 11.3 11 3 decreased cranium length 0.0317409651121898 0.135198032048925 1.30020145044319 0.75 11.3 11 3 increased cornea thickness 0.0317409651121898 0.135198032048925 1.30020145044319 0.75 11.3 11 3 abnormal umbilical vein topology 0.0317409651121898 0.135198032048925 1.30020145044319 0.75 11.3 11 3 embryo cyst 0.0317409651121898 0.135198032048925 1.30020145044319 0.75 11.3 11 3 abnormal placenta morphology 5.84604988979245e-12 3.82685502654177e-10 1.29471536837381 0.746835443037975 11.3 11 3 decreased circulating total protein level 1.10273289312315e-08 4.12488431826142e-07 1.29232144165263 0.745454545454545 11.3 11 3 small lung 3.89945953371499e-08 1.31079805271838e-06 1.29170340174748 0.745098039215686 11.3 11 3 decreased embryo size 1.27380312225776e-64 2.11239017774412e-61 1.29113449472183 0.744769874476987 11.3 11 3 abnormal developmental patterning 3.4312228656442e-12 2.27604450087732e-10 1.28963070694365 0.74390243902439 11.3 11 3 increased circulating serum albumin level 6.28832810550147e-06 0.000123726042625805 1.28781857948659 0.742857142857143 11.3 11 3 decreased triglyceride level 6.28832810550147e-06 0.000123726042625805 1.28781857948659 0.742857142857143 11.3 11 3 pale kidney 2.26658011782473e-05 0.000374625783593955 1.28622078968574 0.741935483870968 11.3 11 3 abnormal heart valve morphology 8.2272342728664e-05 0.00112756172196998 1.28414958068463 0.740740740740741 11.3 11 3 abnormal atrioventricular cushion morphology 8.2272342728664e-05 0.00112756172196998 1.28414958068463 0.740740740740741 11.3 11 3 abnormal type II pneumocyte morphology 8.2272342728664e-05 0.00112756172196998 1.28414958068463 0.740740740740741 11.3 11 3 abnormal fetal cardiomyocyte proliferation 8.2272342728664e-05 0.00112756172196998 1.28414958068463 0.740740740740741 11.3 11 3 abnormal urine homeostasis 9.63033016234395e-14 8.87238751067799e-12 1.28214309696481 0.739583333333333 11.3 11 3 abnormal pulmonary artery morphology 0.000301388479949996 0.00353633888620573 1.28135795116141 0.739130434782609 11.3 11 3 abnormal sacral vertebrae morphology 0.000301388479949996 0.00353633888620573 1.28135795116141 0.739130434782609 11.3 11 3 abnormal vertebral artery topology 0.000301388479949996 0.00353633888620573 1.28135795116141 0.739130434782609 11.3 11 3 decreased hair follicle number 3.59726137788878e-06 7.55121322995641e-05 1.27739089868103 0.736842105263158 11.3 11 3 persistence of hyaloid vascular system 3.59726137788878e-06 7.55121322995641e-05 1.27739089868103 0.736842105263158 11.3 11 3 enlarged liver sinusoidal spaces 1.28910168246754e-05 0.000226617698596325 1.27470730435607 0.735294117647059 11.3 11 3 decreased hepatocyte number 0.00422195367956968 0.0309796748611492 1.27130808487779 0.733333333333333 11.3 11 3 abnormal trophectoderm morphology 0.00422195367956968 0.0309796748611492 1.27130808487779 0.733333333333333 11.3 11 3 decreased thymocyte apoptosis 0.00422195367956968 0.0309796748611492 1.27130808487779 0.733333333333333 11.3 11 3 abnormal branching involved in lung morphogenesis 0.00422195367956968 0.0309796748611492 1.27130808487779 0.733333333333333 11.3 11 3 Leydig cell hyperplasia 2.05196206435365e-06 4.68280333493551e-05 1.26848921994458 0.731707317073171 11.3 11 3 distended pericardium 9.35800551828052e-08 2.87383194157072e-06 1.26686295171388 0.730769230769231 11.3 11 3 increased thymocyte apoptosis 0.000168526239512048 0.00213337924064234 1.26686295171388 0.730769230769231 11.3 11 3 pale liver 2.04743454185875e-10 1.00851354908389e-08 1.26506087070148 0.72972972972973 11.3 11 3 abnormal lung development 9.719019461903e-12 5.9693977559219e-10 1.26450964592122 0.729411764705882 11.3 11 3 enlarged pericardium 2.61748192612972e-05 0.000425554659558673 1.26080140649037 0.727272727272727 11.3 11 3 intracerebral hemorrhage 0.000617007630076213 0.00640837778628218 1.26080140649037 0.727272727272727 11.3 11 3 abnormal circulating lipid level 0.000617007630076213 0.00640837778628218 1.26080140649037 0.727272727272727 11.3 11 3 abnormal cerebral cortex pyramidal cell morphology 0.000617007630076213 0.00640837778628218 1.26080140649037 0.727272727272727 11.3 11 3 abnormal stomach epithelium morphology 0.0163929934176911 0.0865765841327105 1.26080140649037 0.727272727272727 11.3 11 3 failure of somite differentiation 0.0163929934176911 0.0865765841327105 1.26080140649037 0.727272727272727 11.3 11 3 abnormal proximal-distal axis patterning 0.0163929934176911 0.0865765841327105 1.26080140649037 0.727272727272727 11.3 11 3 vasculitis 0.0163929934176911 0.0865765841327105 1.26080140649037 0.727272727272727 11.3 11 3 abnormal primary sex determination 0.0163929934176911 0.0865765841327105 1.26080140649037 0.727272727272727 11.3 11 3 impaired luteinization 0.0163929934176911 0.0865765841327105 1.26080140649037 0.727272727272727 11.3 11 3 abnormal radial glial cell morphology 0.0163929934176911 0.0865765841327105 1.26080140649037 0.727272727272727 11.3 11 3 abnormal coronal suture morphology 0.0163929934176911 0.0865765841327105 1.26080140649037 0.727272727272727 11.3 11 3 increased glycogen level 0.0163929934176911 0.0865765841327105 1.26080140649037 0.727272727272727 11.3 11 3 abnormal palatal shelf elevation 0.0163929934176911 0.0865765841327105 1.26080140649037 0.727272727272727 11.3 11 3 increased number of Howell-Jolly bodies 0.0163929934176911 0.0865765841327105 1.26080140649037 0.727272727272727 11.3 11 3 aorta dilation 0.0163929934176911 0.0865765841327105 1.26080140649037 0.727272727272727 11.3 11 3 hypolactation 0.0163929934176911 0.0865765841327105 1.26080140649037 0.727272727272727 11.3 11 3 thin hypoglossal nerve 0.0163929934176911 0.0865765841327105 1.26080140649037 0.727272727272727 11.3 11 3 microphthalmia 1.39718972816051e-19 2.574451443555e-17 1.25771120696466 0.725490196078431 11.3 11 3 abnormal trophoblast layer morphology 1.88430728962939e-07 5.35681643766069e-06 1.25771120696466 0.725490196078431 11.3 11 3 abnormal spinal nerve morphology 9.41632023609847e-05 0.00126954453047669 1.25536691766929 0.724137931034483 11.3 11 3 abnormal embryonic erythropoiesis 9.41632023609847e-05 0.00126954453047669 1.25536691766929 0.724137931034483 11.3 11 3 polychromatophilia 9.41632023609847e-05 0.00126954453047669 1.25536691766929 0.724137931034483 11.3 11 3 oxidative stress 6.45183869358954e-12 4.11511506418051e-10 1.25204584116752 0.722222222222222 11.3 11 3 abnormal trophoblast giant cell morphology 1.4733842852304e-05 0.000257196028737588 1.25204584116752 0.722222222222222 11.3 11 3 abnormal mitral valve morphology 0.00228682172585294 0.0188672273401631 1.25204584116752 0.722222222222222 11.3 11 3 right pulmonary isomerism 0.00228682172585294 0.0188672273401631 1.25204584116752 0.722222222222222 11.3 11 3 abnormal metacarpal bone morphology 0.00228682172585294 0.0188672273401631 1.25204584116752 0.722222222222222 11.3 11 3 abnormal redox activity 0.00228682172585294 0.0188672273401631 1.25204584116752 0.722222222222222 11.3 11 3 abnormal eye anterior chamber morphology 0.00228682172585294 0.0188672273401631 1.25204584116752 0.722222222222222 11.3 11 3 abnormal glycogen homeostasis 0.00228682172585294 0.0188672273401631 1.25204584116752 0.722222222222222 11.3 11 3 increased effector memory CD4-positive, alpha-beta T cell number 0.00228682172585294 0.0188672273401631 1.25204584116752 0.722222222222222 11.3 11 3 increased effector memory CD8-positive, alpha-beta T cell number 0.00228682172585294 0.0188672273401631 1.25204584116752 0.722222222222222 11.3 11 3 increased adipocyte glucose uptake 0.00228682172585294 0.0188672273401631 1.25204584116752 0.722222222222222 11.3 11 3 increased circulating creatinine level 2.2369738137528e-11 1.25044322735058e-09 1.24980604538725 0.720930232558139 11.3 11 3 kidney failure 2.34300323311466e-06 5.11247415997607e-05 1.24980604538725 0.720930232558139 11.3 11 3 abnormal primitive streak morphology 0.000340947830582281 0.00387263803001563 1.24819339242546 0.72 11.3 11 3 abnormal preimplantation embryo development 0.000340947830582281 0.00387263803001563 1.24819339242546 0.72 11.3 11 3 decreased brain weight 6.10967471542438e-08 1.94843793007925e-06 1.24697682966481 0.719298245614035 11.3 11 3 abnormal circulating amino acid level 6.10967471542438e-08 1.94843793007925e-06 1.24697682966481 0.719298245614035 11.3 11 3 kidney cortex cysts 5.26073019009892e-05 0.000778932520706611 1.24602639000806 0.71875 11.3 11 3 increased fatty acid level 5.26073019009892e-05 0.000778932520706611 1.24602639000806 0.71875 11.3 11 3 pancreatic islet hyperplasia 5.26073019009892e-05 0.000778932520706611 1.24602639000806 0.71875 11.3 11 3 embryonic lethality between implantation and somite formation, complete penetrance 2.50135711257062e-29 1.24442516350388e-26 1.2453630219211 0.718367346938775 11.3 11 3 abnormal iris morphology 8.2885359133738e-06 0.000154439948198632 1.24463728589434 0.717948717948718 11.3 11 3 atrioventricular septal defect 2.13692132232567e-07 6.00631840597187e-06 1.24295987715324 0.716981132075472 11.3 11 3 absent mesoderm 3.47369007328079e-08 1.21701465595577e-06 1.24241471931238 0.716666666666667 11.3 11 3 decreased hemoglobin content 2.59166267053854e-17 4.02922555810289e-15 1.24179996685354 0.716312056737589 11.3 11 3 decreased glycogen level 2.93977386226099e-05 0.000471786289185433 1.23828709566018 0.714285714285714 11.3 11 3 small superior cervical ganglion 0.000188686055395562 0.00237048769089122 1.23828709566018 0.714285714285714 11.3 11 3 abnormal somite shape 0.000188686055395562 0.00237048769089122 1.23828709566018 0.714285714285714 11.3 11 3 abnormal scapula morphology 0.00124483383140837 0.0114262883971524 1.23828709566018 0.714285714285714 11.3 11 3 abnormal salivary gland morphology 0.00124483383140837 0.0114262883971524 1.23828709566018 0.714285714285714 11.3 11 3 abnormal hematopoietic system physiology 0.00124483383140837 0.0114262883971524 1.23828709566018 0.714285714285714 11.3 11 3 midline facial cleft 0.00862465490903582 0.0523903030188684 1.23828709566018 0.714285714285714 11.3 11 3 abnormal kidney blood vessel morphology 0.00862465490903582 0.0523903030188684 1.23828709566018 0.714285714285714 11.3 11 3 abnormal fluid regulation 0.00862465490903582 0.0523903030188684 1.23828709566018 0.714285714285714 11.3 11 3 increased hemangioma incidence 0.00862465490903582 0.0523903030188684 1.23828709566018 0.714285714285714 11.3 11 3 absent olfactory bulb 0.00862465490903582 0.0523903030188684 1.23828709566018 0.714285714285714 11.3 11 3 lysosomal protein accumulation 0.00862465490903582 0.0523903030188684 1.23828709566018 0.714285714285714 11.3 11 3 increased pulmonary respiratory rate 0.00862465490903582 0.0523903030188684 1.23828709566018 0.714285714285714 11.3 11 3 abnormal renal reabsorbtion 0.00862465490903582 0.0523903030188684 1.23828709566018 0.714285714285714 11.3 11 3 asymmetric rib joints 0.0668269103374056 0.218295389972812 1.23828709566018 0.714285714285714 11.3 11 3 broad head 0.0668269103374056 0.218295389972812 1.23828709566018 0.714285714285714 11.3 11 3 abnormal foot pad morphology 0.0668269103374056 0.218295389972812 1.23828709566018 0.714285714285714 11.3 11 3 mammary gland hyperplasia 0.0668269103374056 0.218295389972812 1.23828709566018 0.714285714285714 11.3 11 3 abnormal oculomotor nerve morphology 0.0668269103374056 0.218295389972812 1.23828709566018 0.714285714285714 11.3 11 3 abnormal circulating free fatty acids level 0.0668269103374056 0.218295389972812 1.23828709566018 0.714285714285714 11.3 11 3 decreased activated T cell number 0.0668269103374056 0.218295389972812 1.23828709566018 0.714285714285714 11.3 11 3 abnormal tumor incidence 0.0668269103374056 0.218295389972812 1.23828709566018 0.714285714285714 11.3 11 3 detached tectorial membrane 0.0668269103374056 0.218295389972812 1.23828709566018 0.714285714285714 11.3 11 3 decreased cholesterol efflux 0.0668269103374056 0.218295389972812 1.23828709566018 0.714285714285714 11.3 11 3 aorta coarctation 0.0668269103374056 0.218295389972812 1.23828709566018 0.714285714285714 11.3 11 3 increased ectoderm apoptosis 0.0668269103374056 0.218295389972812 1.23828709566018 0.714285714285714 11.3 11 3 renal necrosis 0.0668269103374056 0.218295389972812 1.23828709566018 0.714285714285714 11.3 11 3 abnormal vestibular saccular macula morphology 0.0668269103374056 0.218295389972812 1.23828709566018 0.714285714285714 11.3 11 3 abnormal strial marginal cell morphology 0.0668269103374056 0.218295389972812 1.23828709566018 0.714285714285714 11.3 11 3 abnormal cochlear nerve compound action potential 0.0668269103374056 0.218295389972812 1.23828709566018 0.714285714285714 11.3 11 3 abnormal ciliary body morphology 0.0668269103374056 0.218295389972812 1.23828709566018 0.714285714285714 11.3 11 3 increased thyroid-stimulating hormone level 0.0668269103374056 0.218295389972812 1.23828709566018 0.714285714285714 11.3 11 3 abnormal renal/urinary system physiology 0.0668269103374056 0.218295389972812 1.23828709566018 0.714285714285714 11.3 11 3 retinal pigment epithelium atrophy 0.0668269103374056 0.218295389972812 1.23828709566018 0.714285714285714 11.3 11 3 abnormal spinal cord central canal morphology 0.0668269103374056 0.218295389972812 1.23828709566018 0.714285714285714 11.3 11 3 abnormal sperm annulus morphology 0.0668269103374056 0.218295389972812 1.23828709566018 0.714285714285714 11.3 11 3 decreased DN2 thymocyte number 0.0668269103374056 0.218295389972812 1.23828709566018 0.714285714285714 11.3 11 3 focal dorsal hair loss 0.0668269103374056 0.218295389972812 1.23828709566018 0.714285714285714 11.3 11 3 decreased skeletal muscle glycogen level 0.0668269103374056 0.218295389972812 1.23828709566018 0.714285714285714 11.3 11 3 abnormal aortic valve cusp morphology 0.0668269103374056 0.218295389972812 1.23828709566018 0.714285714285714 11.3 11 3 thick mitral valve cusps 0.0668269103374056 0.218295389972812 1.23828709566018 0.714285714285714 11.3 11 3 embryonic lethality at implantation, incomplete penetrance 0.0668269103374056 0.218295389972812 1.23828709566018 0.714285714285714 11.3 11 3 small tail bud 0.0668269103374056 0.218295389972812 1.23828709566018 0.714285714285714 11.3 11 3 impaired mammary gland growth during pregnancy 0.0668269103374056 0.218295389972812 1.23828709566018 0.714285714285714 11.3 11 3 absent heart tube 0.0668269103374056 0.218295389972812 1.23828709566018 0.714285714285714 11.3 11 3 absent connection between subcutaneous lymph vessels and lymph sac 0.0668269103374056 0.218295389972812 1.23828709566018 0.714285714285714 11.3 11 3 embryo tumor 0.0668269103374056 0.218295389972812 1.23828709566018 0.714285714285714 11.3 11 3 decreased cell proliferation 6.34141811207215e-22 1.43402523216177e-19 1.23694840690812 0.713513513513514 11.3 11 3 abnormal fertility/fecundity 1.83862342253602e-09 7.68668195556026e-08 1.23489452827481 0.712328767123288 11.3 11 3 abnormal hepatocyte morphology 1.30330592077636e-13 1.13753455366007e-11 1.23382479981996 0.711711711711712 11.3 11 3 eyelids open at birth 4.22395724287265e-07 1.10600985701534e-05 1.23352445298457 0.711538461538462 11.3 11 3 kinked neural tube 4.22395724287265e-07 1.10600985701534e-05 1.23352445298457 0.711538461538462 11.3 11 3 abnormal ectoderm development 2.62107930030832e-06 5.64496515975494e-05 1.23278359745725 0.711111111111111 11.3 11 3 abnormal myocardial trabeculae morphology 2.62107930030832e-06 5.64496515975494e-05 1.23278359745725 0.711111111111111 11.3 11 3 pale yolk sac 1.72393299460304e-10 8.66319863449505e-09 1.2323194470064 0.710843373493976 11.3 11 3 decreased birth body size 7.4434957323063e-14 6.98705495626865e-12 1.23176979515671 0.710526315789474 11.3 11 3 increased circulating alkaline phosphatase level 5.23949775563206e-19 9.3094647622391e-17 1.23064334815611 0.709876543209877 11.3 11 3 abnormal embryo turning 2.38448289353321e-07 6.62726390800432e-06 1.22928137132811 0.709090909090909 11.3 11 3 pallor 2.85974061323712e-20 5.92800397952278e-18 1.2283807988949 0.708571428571429 11.3 11 3 oligodactyly 1.47389371766111e-06 3.41052150947164e-05 1.22796803652968 0.708333333333333 11.3 11 3 vertebral transformation 1.47389371766111e-06 3.41052150947164e-05 1.22796803652968 0.708333333333333 11.3 11 3 abnormal foregut morphology 0.000680521949140875 0.00693769814954068 1.22796803652968 0.708333333333333 11.3 11 3 abnormal truncus arteriosus septation 0.000680521949140875 0.00693769814954068 1.22796803652968 0.708333333333333 11.3 11 3 abnormal lung saccule morphology 0.000680521949140875 0.00693769814954068 1.22796803652968 0.708333333333333 11.3 11 3 abnormal extraembryonic tissue morphology 2.99514917180281e-12 2.01363069320527e-10 1.22371901218183 0.705882352941177 11.3 11 3 failure of chorioallantoic fusion 8.28894304736417e-07 2.05161650052919e-05 1.22371901218183 0.705882352941177 11.3 11 3 abnormal dorsal-ventral axis patterning 0.00459546846660206 0.0330860428673592 1.22371901218183 0.705882352941177 11.3 11 3 abnormal embryonic-extraembryonic boundary morphology 0.00459546846660206 0.0330860428673592 1.22371901218183 0.705882352941177 11.3 11 3 abnormal ectoplacental cone morphology 0.00459546846660206 0.0330860428673592 1.22371901218183 0.705882352941177 11.3 11 3 abnormal tarsal bone morphology 0.00459546846660206 0.0330860428673592 1.22371901218183 0.705882352941177 11.3 11 3 increased brain size 0.00459546846660206 0.0330860428673592 1.22371901218183 0.705882352941177 11.3 11 3 increased hepatoma incidence 0.00459546846660206 0.0330860428673592 1.22371901218183 0.705882352941177 11.3 11 3 increased circulating alanine transaminase level 1.15942231021754e-09 5.05975964327392e-08 1.22241162007479 0.705128205128205 11.3 11 3 abnormal cell cycle 1.61395405293258e-13 1.33823690222326e-11 1.22105875345969 0.704347826086957 11.3 11 3 embryonic lethality before implantation, complete penetrance 1.53227364969641e-14 1.65718726244339e-12 1.22045576148268 0.704 11.3 11 3 embryonic growth arrest 2.77892608457834e-25 9.2167715138515e-23 1.21882057363234 0.703056768558952 11.3 11 3 increased erythroid progenitor cell number 3.22730215590295e-05 0.000509708832559275 1.21820676437921 0.702702702702703 11.3 11 3 abnormal chromosome morphology 3.22730215590295e-05 0.000509708832559275 1.21820676437921 0.702702702702703 11.3 11 3 abnormal humerus morphology 3.22730215590295e-05 0.000509708832559275 1.21820676437921 0.702702702702703 11.3 11 3 increased cellular sensitivity to gamma-irradiation 2.88108997424466e-06 6.15168352869837e-05 1.21720986850001 0.702127659574468 11.3 11 3 embryonic lethality during organogenesis, complete penetrance 1.66809507848086e-59 2.07469325386057e-56 1.21661707148613 0.701785714285714 11.3 11 3 abnormal cell morphology 3.12888545796071e-13 2.55183691038599e-11 1.2165627606486 0.701754385964912 11.3 11 3 abnormal incisor morphology 1.47598633254304e-07 4.26920465372189e-06 1.21352135374698 0.7 11.3 11 3 abnormal optic cup morphology 0.00020549724482498 0.00254315620150318 1.21352135374698 0.7 11.3 11 3 abnormal brain vasculature morphology 0.00020549724482498 0.00254315620150318 1.21352135374698 0.7 11.3 11 3 abnormal fat pad morphology 0.00020549724482498 0.00254315620150318 1.21352135374698 0.7 11.3 11 3 abnormal cellular respiration 0.00020549724482498 0.00254315620150318 1.21352135374698 0.7 11.3 11 3 abnormal pericardium morphology 0.00247133498983297 0.0198946465605486 1.21352135374698 0.7 11.3 11 3 abnormal circulating enzyme level 0.00247133498983297 0.0198946465605486 1.21352135374698 0.7 11.3 11 3 abnormal lens epithelium morphology 0.00247133498983297 0.0198946465605486 1.21352135374698 0.7 11.3 11 3 kidney atrophy 0.00247133498983297 0.0198946465605486 1.21352135374698 0.7 11.3 11 3 abnormal auchene hair morphology 0.0334043440016832 0.138089367743607 1.21352135374698 0.7 11.3 11 3 increased cranium width 0.0334043440016832 0.138089367743607 1.21352135374698 0.7 11.3 11 3 jaundice 0.0334043440016832 0.138089367743607 1.21352135374698 0.7 11.3 11 3 abnormal prostate gland epithelium morphology 0.0334043440016832 0.138089367743607 1.21352135374698 0.7 11.3 11 3 abnormal epidermis suprabasal layer morphology 0.0334043440016832 0.138089367743607 1.21352135374698 0.7 11.3 11 3 abnormal gland morphology 0.0334043440016832 0.138089367743607 1.21352135374698 0.7 11.3 11 3 abnormal tibialis anterior morphology 0.0334043440016832 0.138089367743607 1.21352135374698 0.7 11.3 11 3 aneurysm 0.0334043440016832 0.138089367743607 1.21352135374698 0.7 11.3 11 3 abnormal pillar cell morphology 0.0334043440016832 0.138089367743607 1.21352135374698 0.7 11.3 11 3 abnormal embryonic erythrocyte morphology 0.0334043440016832 0.138089367743607 1.21352135374698 0.7 11.3 11 3 abnormal placental transport 0.0334043440016832 0.138089367743607 1.21352135374698 0.7 11.3 11 3 abnormal deltoid tuberosity morphology 0.0334043440016832 0.138089367743607 1.21352135374698 0.7 11.3 11 3 abnormal corneal endothelium morphology 0.0334043440016832 0.138089367743607 1.21352135374698 0.7 11.3 11 3 protruding tongue 0.0334043440016832 0.138089367743607 1.21352135374698 0.7 11.3 11 3 abnormal cerebellar granule cell migration 0.0334043440016832 0.138089367743607 1.21352135374698 0.7 11.3 11 3 abnormal left subclavian artery morphology 0.0334043440016832 0.138089367743607 1.21352135374698 0.7 11.3 11 3 thick aortic valve cusps 0.0334043440016832 0.138089367743607 1.21352135374698 0.7 11.3 11 3 thick aortic valve 0.0334043440016832 0.138089367743607 1.21352135374698 0.7 11.3 11 3 decreased circulating lactate level 0.0334043440016832 0.138089367743607 1.21352135374698 0.7 11.3 11 3 increased fatty acid oxidation 0.0334043440016832 0.138089367743607 1.21352135374698 0.7 11.3 11 3 abnormal embryo size 6.04379429869462e-13 4.55573888424329e-11 1.21198719274351 0.699115044247788 11.3 11 3 embryonic lethality, complete penetrance 7.1668463414258e-34 3.96167339428815e-31 1.21189100710065 0.699059561128527 11.3 11 3 abnormal neural tube closure 7.20164758278901e-10 3.22776547066444e-08 1.21143267671815 0.698795180722892 11.3 11 3 decreased susceptibility to hepatic steatosis 8.30750272910461e-08 2.58311412983096e-06 1.21076960464551 0.698412698412698 11.3 11 3 preweaning lethality, complete penetrance 2.07877932766679e-76 1.03419271551423e-72 1.20883594311475 0.697297297297297 11.3 11 3 increased bone mineral content 2.05210148363171e-12 1.43791618043208e-10 1.20874997227746 0.697247706422018 11.3 11 3 decreased bone mineral content 2.42158339342263e-22 6.69298743459866e-20 1.20852057893758 0.697115384615385 11.3 11 3 increased cardiomyocyte apoptosis 0.00011340201197228 0.00151842044933279 1.20826801455327 0.696969696969697 11.3 11 3 abnormal somite development 2.45523076323083e-09 1.01789775392278e-07 1.20693805526372 0.69620253164557 11.3 11 3 abnormal allantois morphology 5.5852053578891e-06 0.00011295283193292 1.20598395403426 0.695652173913043 11.3 11 3 hypotension 0.00133842283036472 0.0120846707460335 1.20598395403426 0.695652173913043 11.3 11 3 abnormal hepatocyte physiology 0.00133842283036472 0.0120846707460335 1.20598395403426 0.695652173913043 11.3 11 3 abnormal hematopoietic stem cell physiology 0.00133842283036472 0.0120846707460335 1.20598395403426 0.695652173913043 11.3 11 3 heart right ventricle hypertrophy 6.27247744642146e-05 0.000915119510145067 1.20389023189184 0.694444444444444 11.3 11 3 hemorrhage 1.48115982086843e-24 4.60548131801278e-22 1.20245580948789 0.693617021276596 11.3 11 3 small liver 4.70894747213787e-09 1.88927529628112e-07 1.20018595425525 0.692307692307692 11.3 11 3 abnormal placenta vasculature 1.743516110747e-06 4.01573733841034e-05 1.20018595425525 0.692307692307692 11.3 11 3 heart inflammation 0.000728896410490305 0.00738545751973374 1.20018595425525 0.692307692307692 11.3 11 3 absent myocardial trabeculae 0.0172239383015731 0.0873209883788731 1.20018595425525 0.692307692307692 11.3 11 3 abnormal renal/urinary system morphology 0.0172239383015731 0.0873209883788731 1.20018595425525 0.692307692307692 11.3 11 3 increased foot pad pigmentation 0.0172239383015731 0.0873209883788731 1.20018595425525 0.692307692307692 11.3 11 3 tight skin 0.0172239383015731 0.0873209883788731 1.20018595425525 0.692307692307692 11.3 11 3 abnormal grip strength 0.0172239383015731 0.0873209883788731 1.20018595425525 0.692307692307692 11.3 11 3 increased pituitary adenoma incidence 0.0172239383015731 0.0873209883788731 1.20018595425525 0.692307692307692 11.3 11 3 abnormal pulmonary alveolus epithelial cell morphology 0.0172239383015731 0.0873209883788731 1.20018595425525 0.692307692307692 11.3 11 3 abnormal tail bud morphology 0.0172239383015731 0.0873209883788731 1.20018595425525 0.692307692307692 11.3 11 3 abnormal bile duct development 0.0172239383015731 0.0873209883788731 1.20018595425525 0.692307692307692 11.3 11 3 abnormal coping response 0.0172239383015731 0.0873209883788731 1.20018595425525 0.692307692307692 11.3 11 3 abnormal telomere length 0.0172239383015731 0.0873209883788731 1.20018595425525 0.692307692307692 11.3 11 3 axonal dystrophy 0.0172239383015731 0.0873209883788731 1.20018595425525 0.692307692307692 11.3 11 3 increased circulating thyroid-stimulating hormone level 0.0172239383015731 0.0873209883788731 1.20018595425525 0.692307692307692 11.3 11 3 abnormal exocrine pancreas morphology 0.0172239383015731 0.0873209883788731 1.20018595425525 0.692307692307692 11.3 11 3 increased circulating ammonia level 0.0172239383015731 0.0873209883788731 1.20018595425525 0.692307692307692 11.3 11 3 increased prostaglandin level 0.0172239383015731 0.0873209883788731 1.20018595425525 0.692307692307692 11.3 11 3 increased circulating calcium level 9.75400961874227e-07 2.40228702243776e-05 1.19776133616585 0.690909090909091 11.3 11 3 decreased liver weight 2.83891316695393e-08 1.00882807182827e-06 1.1964295036942 0.690140845070423 11.3 11 3 decreased trophoblast giant cell number 0.000398736839916846 0.00445778826648609 1.19558754063742 0.689655172413793 11.3 11 3 abnormal outer ear morphology 0.000398736839916846 0.00445778826648609 1.19558754063742 0.689655172413793 11.3 11 3 lethality throughout fetal growth and development, complete penetrance 1.14283028109113e-19 2.18676178785706e-17 1.19527291233725 0.689473684210526 11.3 11 3 trabecula carnea hypoplasia 1.07333360823406e-05 0.000196317452241341 1.19425911003671 0.688888888888889 11.3 11 3 decreased circulating HDL cholesterol level 1.39296271729681e-13 1.17457449466977e-11 1.19185132957293 0.6875 11.3 11 3 small heart 5.9769217387285e-06 0.000118940742600697 1.19185132957293 0.6875 11.3 11 3 failure of tooth eruption 0.00905195414363942 0.0534813193603255 1.19185132957293 0.6875 11.3 11 3 intraventricular hemorrhage 0.00905195414363942 0.0534813193603255 1.19185132957293 0.6875 11.3 11 3 abnormal molar crown morphology 0.00905195414363942 0.0534813193603255 1.19185132957293 0.6875 11.3 11 3 blepharitis 0.00905195414363942 0.0534813193603255 1.19185132957293 0.6875 11.3 11 3 dystonia 0.00905195414363942 0.0534813193603255 1.19185132957293 0.6875 11.3 11 3 decreased circulating triiodothyronine level 0.00905195414363942 0.0534813193603255 1.19185132957293 0.6875 11.3 11 3 decreased fibroblast apoptosis 0.00905195414363942 0.0534813193603255 1.19185132957293 0.6875 11.3 11 3 abnormal vitelline vasculature morphology 2.58591143645028e-12 1.78679297171391e-10 1.19090915460884 0.68695652173913 11.3 11 3 increased mean corpuscular hemoglobin 8.5391958863751e-11 4.47184205628591e-09 1.19075688390757 0.686868686868687 11.3 11 3 abnormal embryonic epiblast morphology 0.000120582941079911 0.00159547907412915 1.18875561183377 0.685714285714286 11.3 11 3 decreased circulating thyroxine level 0.000120582941079911 0.00159547907412915 1.18875561183377 0.685714285714286 11.3 11 3 increased hepatocellular carcinoma incidence 1.03924467062274e-06 2.54691735780695e-05 1.18614869163238 0.684210526315789 11.3 11 3 impaired branching involved in ureteric bud morphogenesis 6.65889428809631e-05 0.000963023229165091 1.18614869163238 0.684210526315789 11.3 11 3 abnormal triglyceride level 0.00481934714540766 0.033580184941741 1.18614869163238 0.684210526315789 11.3 11 3 irregular coat pigmentation 0.00481934714540766 0.033580184941741 1.18614869163238 0.684210526315789 11.3 11 3 decreased germ cell number 0.00481934714540766 0.033580184941741 1.18614869163238 0.684210526315789 11.3 11 3 abnormal optic vesicle formation 0.00481934714540766 0.033580184941741 1.18614869163238 0.684210526315789 11.3 11 3 increased left ventricle weight 0.00481934714540766 0.033580184941741 1.18614869163238 0.684210526315789 11.3 11 3 increased liver cholesterol level 0.00481934714540766 0.033580184941741 1.18614869163238 0.684210526315789 11.3 11 3 decreased liver glycogen level 0.00481934714540766 0.033580184941741 1.18614869163238 0.684210526315789 11.3 11 3 abnormal embryo development 4.75946091953995e-14 4.83230981116557e-12 1.18547779305114 0.683823529411765 11.3 11 3 abnormal placenta labyrinth morphology 9.57697556337717e-09 3.63705751357263e-07 1.1849937269862 0.683544303797468 11.3 11 3 prenatal lethality, complete penetrance 4.06991664262719e-27 1.55752579208233e-24 1.18483585412089 0.683453237410072 11.3 11 3 lethality at weaning, incomplete penetrance 3.68553724166501e-05 0.000576589552744763 1.18392327194827 0.682926829268293 11.3 11 3 muscular atrophy 2.04386298271343e-05 0.00034585776663263 1.18200131858472 0.681818181818182 11.3 11 3 abnormal mesenteric lymph node morphology 0.00259017569140584 0.0207506023586861 1.18200131858472 0.681818181818182 11.3 11 3 increased adenoma incidence 0.00259017569140584 0.0207506023586861 1.18200131858472 0.681818181818182 11.3 11 3 lethality throughout fetal growth and development, incomplete penetrance 8.61704412480807e-18 1.38289659744904e-15 1.18156109462994 0.681564245810056 11.3 11 3 perinatal lethality, incomplete penetrance 4.70945080134289e-22 1.17147588683404e-19 1.18130397267405 0.68141592920354 11.3 11 3 increased grip strength 9.59308551456679e-10 4.22350446327166e-08 1.18113538355279 0.681318681318681 11.3 11 3 microcephaly 1.02113184983137e-07 3.11664475638715e-06 1.18085928832522 0.681159420289855 11.3 11 3 abnormal interventricular septum morphology 6.31686730190039e-06 0.000123726042625805 1.17884931506849 0.68 11.3 11 3 decreased circulating alkaline phosphatase level 6.31686730190039e-06 0.000123726042625805 1.17884931506849 0.68 11.3 11 3 spontaneous skin ulceration 0.00140211695107788 0.0125685258227252 1.17884931506849 0.68 11.3 11 3 enlarged kidney 3.51914904451149e-06 7.45011340274241e-05 1.17754093625044 0.679245283018868 11.3 11 3 increased circulating bilirubin level 3.51914904451149e-06 7.45011340274241e-05 1.17754093625044 0.679245283018868 11.3 11 3 abnormal mitotic spindle morphology 0.000763287087768528 0.00764054982223023 1.17637274087717 0.678571428571429 11.3 11 3 increased insulin sensitivity 3.02736591028255e-14 3.1377386257616e-12 1.17593977336121 0.678321678321678 11.3 11 3 short limbs 3.20183206957699e-09 1.31645574761533e-07 1.17566108162679 0.67816091954023 11.3 11 3 osteopetrosis 0.000417414272899702 0.00462502451598222 1.17437550362611 0.67741935483871 11.3 11 3 abnormal postnatal growth/weight/body size 0.000417414272899702 0.00462502451598222 1.17437550362611 0.67741935483871 11.3 11 3 inner cell mass degeneration 0.000417414272899702 0.00462502451598222 1.17437550362611 0.67741935483871 11.3 11 3 decreased neuronal precursor cell number 0.000417414272899702 0.00462502451598222 1.17437550362611 0.67741935483871 11.3 11 3 abnormal brain morphology 9.8281754034214e-16 1.16417077695289e-13 1.17368081240835 0.677018633540373 11.3 11 3 decreased circulating serum albumin level 3.20952540432308e-10 1.55023193072887e-08 1.17324575326187 0.676767676767677 11.3 11 3 abnormal endoderm development 0.000229125606322376 0.00280073683403888 1.17273072000758 0.676470588235294 11.3 11 3 abnormal respiratory electron transport chain 0.000126165926350017 0.00165613584061038 1.17135265805693 0.675675675675676 11.3 11 3 abnormal blood homeostasis 1.82136230850522e-11 1.02969062327426e-09 1.17094165712428 0.675438596491228 11.3 11 3 edema 1.86412290765931e-16 2.5761142960014e-14 1.16917339729775 0.674418604651163 11.3 11 3 abnormal forelimb morphology 2.13728062462074e-05 0.0003592219968746 1.16829695547069 0.673913043478261 11.3 11 3 polydactyly 5.98387397499527e-10 2.75646046533347e-08 1.16752783305103 0.673469387755102 11.3 11 3 increased sarcoma incidence 1.18711200299644e-05 0.00021244180629163 1.16752783305103 0.673469387755102 11.3 11 3 abnormal neural tube morphology 1.92308689358586e-15 2.17439938536128e-13 1.16643586912188 0.672839506172839 11.3 11 3 decreased hematocrit 6.2191426763969e-14 6.06671270883815e-12 1.16365061318203 0.671232876712329 11.3 11 3 abnormal visceral yolk sac morphology 3.52992861707519e-08 1.22806957132511e-06 1.16304939870868 0.670886075949367 11.3 11 3 small kidney 6.24843189915226e-09 2.46713878557798e-07 1.16230129660831 0.670454545454545 11.3 11 3 abnormal liver morphology 1.15452595641895e-16 1.68934312740714e-14 1.16219124061961 0.670391061452514 11.3 11 3 abnormal liver physiology 6.24691420754948e-10 2.85122919106043e-08 1.16151329572925 0.67 11.3 11 3 cataract 1.12301682632786e-11 6.73133579636277e-10 1.16051038551954 0.669421487603306 11.3 11 3 increased blood urea nitrogen level 1.14961218921089e-13 1.02130725737931e-11 1.15971991441829 0.668965517241379 11.3 11 3 decreased erythrocyte cell number 1.16623458790282e-14 1.28933712773701e-12 1.15941530612769 0.668789808917197 11.3 11 3 abnormal kidney development 2.12567189273619e-06 4.78516636486992e-05 1.15573462261617 0.666666666666667 11.3 11 3 increased erythrocyte cell number 2.12567189273619e-06 4.78516636486992e-05 1.15573462261617 0.666666666666667 11.3 11 3 muscular ventricular septal defect 2.12567189273619e-06 4.78516636486992e-05 1.15573462261617 0.666666666666667 11.3 11 3 abnormal fontanelle morphology 0.0174300573679681 0.0873209883788731 1.15573462261617 0.666666666666667 11.3 11 3 macrocytosis 0.0174300573679681 0.0873209883788731 1.15573462261617 0.666666666666667 11.3 11 3 placental labyrinth hypoplasia 0.0174300573679681 0.0873209883788731 1.15573462261617 0.666666666666667 11.3 11 3 delayed intramembranous bone ossification 0.0174300573679681 0.0873209883788731 1.15573462261617 0.666666666666667 11.3 11 3 abnormal glial cell morphology 0.0174300573679681 0.0873209883788731 1.15573462261617 0.666666666666667 11.3 11 3 abnormal olfactory nerve morphology 0.0174300573679681 0.0873209883788731 1.15573462261617 0.666666666666667 11.3 11 3 abnormal secondary palate development 0.0174300573679681 0.0873209883788731 1.15573462261617 0.666666666666667 11.3 11 3 increased exploration in new environment 3.66355893506457e-08 1.2569797035825e-06 1.15573462261617 0.666666666666667 11.3 11 3 increased rib number 6.53051794962027e-08 2.05628650628866e-06 1.15573462261617 0.666666666666667 11.3 11 3 abnormal cornea morphology 6.53051794962027e-08 2.05628650628866e-06 1.15573462261617 0.666666666666667 11.3 11 3 abnormal forebrain development 2.07884854535441e-07 5.87629063246488e-06 1.15573462261617 0.666666666666667 11.3 11 3 failure of heart looping 0.000130238364085184 0.00169641195832865 1.15573462261617 0.666666666666667 11.3 11 3 abnormal lysosome morphology 0.000236299274311306 0.0028649829872829 1.15573462261617 0.666666666666667 11.3 11 3 narrow eye opening 0.000236299274311306 0.0028649829872829 1.15573462261617 0.666666666666667 11.3 11 3 abnormal epidermis stratum basale morphology 0.000429997776915704 0.00472238176634796 1.15573462261617 0.666666666666667 11.3 11 3 decreased brown adipose tissue amount 0.000429997776915704 0.00472238176634796 1.15573462261617 0.666666666666667 11.3 11 3 abnormal QRS complex 0.000429997776915704 0.00472238176634796 1.15573462261617 0.666666666666667 11.3 11 3 thin epidermis 0.00143993074272573 0.0127922418661795 1.15573462261617 0.666666666666667 11.3 11 3 abnormal palate morphology 0.00143993074272573 0.0127922418661795 1.15573462261617 0.666666666666667 11.3 11 3 abnormal bone trabecula morphology 0.00143993074272573 0.0127922418661795 1.15573462261617 0.666666666666667 11.3 11 3 ocular hypertelorism 0.00265422459281239 0.0208821583297937 1.15573462261617 0.666666666666667 11.3 11 3 abnormal nursing 0.00265422459281239 0.0208821583297937 1.15573462261617 0.666666666666667 11.3 11 3 hemolytic anemia 0.00265422459281239 0.0208821583297937 1.15573462261617 0.666666666666667 11.3 11 3 blindness 0.00265422459281239 0.0208821583297937 1.15573462261617 0.666666666666667 11.3 11 3 increased hemangiosarcoma incidence 0.00265422459281239 0.0208821583297937 1.15573462261617 0.666666666666667 11.3 11 3 abnormal osteoblast morphology 0.00265422459281239 0.0208821583297937 1.15573462261617 0.666666666666667 11.3 11 3 increased body temperature 0.00265422459281239 0.0208821583297937 1.15573462261617 0.666666666666667 11.3 11 3 abnormal eye pigmentation 0.0049243373066822 0.0340202648499215 1.15573462261617 0.666666666666667 11.3 11 3 left pulmonary isomerism 0.0049243373066822 0.0340202648499215 1.15573462261617 0.666666666666667 11.3 11 3 abnormal phrenic nerve morphology 0.00921276194810029 0.0534813193603255 1.15573462261617 0.666666666666667 11.3 11 3 abnormal iron level 0.00921276194810029 0.0534813193603255 1.15573462261617 0.666666666666667 11.3 11 3 absent allantois 0.00921276194810029 0.0534813193603255 1.15573462261617 0.666666666666667 11.3 11 3 increased circulating renin level 0.00921276194810029 0.0534813193603255 1.15573462261617 0.666666666666667 11.3 11 3 decreased lactate dehydrogenase level 0.00921276194810029 0.0534813193603255 1.15573462261617 0.666666666666667 11.3 11 3 small thoracic cage 0.00921276194810029 0.0534813193603255 1.15573462261617 0.666666666666667 11.3 11 3 abnormal metanephric mesenchyme morphology 0.00921276194810029 0.0534813193603255 1.15573462261617 0.666666666666667 11.3 11 3 mesocardia 0.0335022847972933 0.138089367743607 1.15573462261617 0.666666666666667 11.3 11 3 abnormal respiratory function 0.0335022847972933 0.138089367743607 1.15573462261617 0.666666666666667 11.3 11 3 small thyroid gland 0.0335022847972933 0.138089367743607 1.15573462261617 0.666666666666667 11.3 11 3 decreased circulating ketone body level 0.0335022847972933 0.138089367743607 1.15573462261617 0.666666666666667 11.3 11 3 hematuria 0.0335022847972933 0.138089367743607 1.15573462261617 0.666666666666667 11.3 11 3 abnormal fatty acid level 0.0335022847972933 0.138089367743607 1.15573462261617 0.666666666666667 11.3 11 3 abnormal thymus corticomedullary boundary morphology 0.0335022847972933 0.138089367743607 1.15573462261617 0.666666666666667 11.3 11 3 distorted hair follicle pattern 0.0659620722017682 0.218295389972812 1.15573462261617 0.666666666666667 11.3 11 3 crypts of Lieberkuhn abscesses 0.0659620722017682 0.218295389972812 1.15573462261617 0.666666666666667 11.3 11 3 renal tubular acidosis 0.0659620722017682 0.218295389972812 1.15573462261617 0.666666666666667 11.3 11 3 abnormal urinary bladder urothelium morphology 0.0659620722017682 0.218295389972812 1.15573462261617 0.666666666666667 11.3 11 3 synostosis 0.0659620722017682 0.218295389972812 1.15573462261617 0.666666666666667 11.3 11 3 abnormal geniculate ganglion morphology 0.0659620722017682 0.218295389972812 1.15573462261617 0.666666666666667 11.3 11 3 abnormal lens vesicle development 0.0659620722017682 0.218295389972812 1.15573462261617 0.666666666666667 11.3 11 3 abnormal kindling response 0.0659620722017682 0.218295389972812 1.15573462261617 0.666666666666667 11.3 11 3 decreased level of surface class I molecules 0.0659620722017682 0.218295389972812 1.15573462261617 0.666666666666667 11.3 11 3 increased pheochromocytoma incidence 0.0659620722017682 0.218295389972812 1.15573462261617 0.666666666666667 11.3 11 3 abnormal posterior semicircular canal morphology 0.0659620722017682 0.218295389972812 1.15573462261617 0.666666666666667 11.3 11 3 abnormal postural reflex 0.0659620722017682 0.218295389972812 1.15573462261617 0.666666666666667 11.3 11 3 decreased circulating bicarbonate level 0.0659620722017682 0.218295389972812 1.15573462261617 0.666666666666667 11.3 11 3 abnormal lens capsule morphology 0.0659620722017682 0.218295389972812 1.15573462261617 0.666666666666667 11.3 11 3 biliary cyst 0.0659620722017682 0.218295389972812 1.15573462261617 0.666666666666667 11.3 11 3 premature bone ossification 0.0659620722017682 0.218295389972812 1.15573462261617 0.666666666666667 11.3 11 3 premature neuronal precursor differentiation 0.0659620722017682 0.218295389972812 1.15573462261617 0.666666666666667 11.3 11 3 decreased fear-related response 0.0659620722017682 0.218295389972812 1.15573462261617 0.666666666666667 11.3 11 3 decreased cellular sensitivity to ionizing radiation 0.0659620722017682 0.218295389972812 1.15573462261617 0.666666666666667 11.3 11 3 small scapula 0.0659620722017682 0.218295389972812 1.15573462261617 0.666666666666667 11.3 11 3 increased neuronal precursor cell number 0.0659620722017682 0.218295389972812 1.15573462261617 0.666666666666667 11.3 11 3 abnormal gallbladder physiology 0.0659620722017682 0.218295389972812 1.15573462261617 0.666666666666667 11.3 11 3 abnormal posterior eye segment morphology 0.0659620722017682 0.218295389972812 1.15573462261617 0.666666666666667 11.3 11 3 abnormal intervertebral disk development 0.0659620722017682 0.218295389972812 1.15573462261617 0.666666666666667 11.3 11 3 hemothorax 0.0659620722017682 0.218295389972812 1.15573462261617 0.666666666666667 11.3 11 3 absent adrenal gland 0.0659620722017682 0.218295389972812 1.15573462261617 0.666666666666667 11.3 11 3 abnormal inguinal fat pad morphology 0.0659620722017682 0.218295389972812 1.15573462261617 0.666666666666667 11.3 11 3 decreased susceptibility to atherosclerosis 0.0659620722017682 0.218295389972812 1.15573462261617 0.666666666666667 11.3 11 3 enhanced conditioned place preference behavior 0.0659620722017682 0.218295389972812 1.15573462261617 0.666666666666667 11.3 11 3 abnormal liver vasculature morphology 0.0659620722017682 0.218295389972812 1.15573462261617 0.666666666666667 11.3 11 3 abnormal hippocampus granule cell morphology 0.0659620722017682 0.218295389972812 1.15573462261617 0.666666666666667 11.3 11 3 abnormal cerebellar layer morphology 0.0659620722017682 0.218295389972812 1.15573462261617 0.666666666666667 11.3 11 3 abnormal incisor color 0.0659620722017682 0.218295389972812 1.15573462261617 0.666666666666667 11.3 11 3 abnormal telomere morphology 0.0659620722017682 0.218295389972812 1.15573462261617 0.666666666666667 11.3 11 3 shortened ST segment 0.0659620722017682 0.218295389972812 1.15573462261617 0.666666666666667 11.3 11 3 iris coloboma 0.0659620722017682 0.218295389972812 1.15573462261617 0.666666666666667 11.3 11 3 decreased effector memory CD4-positive, alpha-beta T cell number 0.0659620722017682 0.218295389972812 1.15573462261617 0.666666666666667 11.3 11 3 abnormal pulmonary alveolar parenchyma morphology 0.0659620722017682 0.218295389972812 1.15573462261617 0.666666666666667 11.3 11 3 abnormal oxidative phosphorylation 0.0659620722017682 0.218295389972812 1.15573462261617 0.666666666666667 11.3 11 3 decreased pancreatic beta cell proliferation 0.0659620722017682 0.218295389972812 1.15573462261617 0.666666666666667 11.3 11 3 increased myeloid cell number 0.0659620722017682 0.218295389972812 1.15573462261617 0.666666666666667 11.3 11 3 abnormal ductus venosus valve topology 0.0659620722017682 0.218295389972812 1.15573462261617 0.666666666666667 11.3 11 3 abnormal coronary sinus connection 0.0659620722017682 0.218295389972812 1.15573462261617 0.666666666666667 11.3 11 3 increased cardiac muscle glycogen level 0.0659620722017682 0.218295389972812 1.15573462261617 0.666666666666667 11.3 11 3 decreased platelet dense granule number 0.0659620722017682 0.218295389972812 1.15573462261617 0.666666666666667 11.3 11 3 double outlet right ventricle 3.77665662369899e-10 1.7894158764669e-08 1.15033399353852 0.663551401869159 11.3 11 3 perinatal lethality, complete penetrance 1.43421771452394e-18 2.46042521715745e-16 1.14759564640056 0.661971830985915 11.3 11 3 decreased total body fat amount 3.1357785666971e-28 1.41822712448346e-25 1.14708391436305 0.661676646706587 11.3 11 3 pericardial effusion 2.18556559159529e-06 4.89783280098494e-05 1.1464141821112 0.661290322580645 11.3 11 3 decreased circulating cholesterol level 4.34092894568883e-16 5.68318986968472e-14 1.14626138800456 0.66120218579235 11.3 11 3 extramedullary hematopoiesis 6.90529623217485e-10 3.12307715955181e-08 1.14483146579904 0.660377358490566 11.3 11 3 increased B cell derived lymphoma incidence 2.26529047373831e-05 0.000374625783593955 1.14417727639001 0.66 11.3 11 3 abnormal embryonic tissue morphology 4.13262730398674e-13 3.21247200583344e-11 1.14394141218131 0.659863945578231 11.3 11 3 hepatic necrosis 4.07842727149268e-05 0.000618602916941344 1.1434395734394 0.659574468085106 11.3 11 3 abnormal cell nucleus morphology 4.07842727149268e-05 0.000618602916941344 1.1434395734394 0.659574468085106 11.3 11 3 increased respiratory quotient 4.07842727149268e-05 0.000618602916941344 1.1434395734394 0.659574468085106 11.3 11 3 osteoporosis 7.35547516385568e-05 0.00103080250535724 1.14260127463189 0.659090909090909 11.3 11 3 renal interstitial fibrosis 7.35547516385568e-05 0.00103080250535724 1.14260127463189 0.659090909090909 11.3 11 3 decreased blood urea nitrogen level 7.35547516385568e-05 0.00103080250535724 1.14260127463189 0.659090909090909 11.3 11 3 thick ventricular wall 0.000132918164536076 0.00171757887939475 1.14164029795012 0.658536585365854 11.3 11 3 abnormal cell differentiation 0.000132918164536076 0.00171757887939475 1.14164029795012 0.658536585365854 11.3 11 3 abnormal myocardium layer morphology 1.23094307382254e-07 3.66703101333362e-06 1.14110507043115 0.658227848101266 11.3 11 3 astrocytosis 3.91465207137612e-07 1.04706419651055e-05 1.13990264148444 0.657534246575342 11.3 11 3 abnormal liver development 0.000437165714703769 0.00474868871321234 1.13922412800737 0.657142857142857 11.3 11 3 thick pulmonary interalveolar septum 0.000437165714703769 0.00474868871321234 1.13922412800737 0.657142857142857 11.3 11 3 increased red blood cell distribution width 0.000437165714703769 0.00474868871321234 1.13922412800737 0.657142857142857 11.3 11 3 failure of primitive streak formation 0.000796331284251695 0.00778698143027895 1.13767626913779 0.65625 11.3 11 3 abnormal lumbar vertebrae morphology 0.000796331284251695 0.00778698143027895 1.13767626913779 0.65625 11.3 11 3 abnormal embryonic hematopoiesis 0.000796331284251695 0.00778698143027895 1.13767626913779 0.65625 11.3 11 3 abnormal spongiotrophoblast layer morphology 0.000796331284251695 0.00778698143027895 1.13767626913779 0.65625 11.3 11 3 bradykinesia 0.000796331284251695 0.00778698143027895 1.13767626913779 0.65625 11.3 11 3 abnormal embryonic neuroepithelium morphology 7.15158370326991e-06 0.000137371154145822 1.13580816360555 0.655172413793103 11.3 11 3 abnormal retinal pigmentation 3.9611028722026e-08 1.32258300598711e-06 1.13580816360555 0.655172413793103 11.3 11 3 abnormal platelet physiology 1.28227208731752e-05 0.000226216440936336 1.13472126584133 0.654545454545455 11.3 11 3 abnormal ureter morphology 0.00267375574996555 0.0208821583297937 1.13350895679663 0.653846153846154 11.3 11 3 thick skin 0.00267375574996555 0.0208821583297937 1.13350895679663 0.653846153846154 11.3 11 3 abnormal erythrocyte osmotic lysis 0.00267375574996555 0.0208821583297937 1.13350895679663 0.653846153846154 11.3 11 3 decreased bone resorption 0.00267375574996555 0.0208821583297937 1.13350895679663 0.653846153846154 11.3 11 3 abnormal lipid homeostasis 2.37170200447225e-11 1.31102416358327e-09 1.13350895679663 0.653846153846154 11.3 11 3 decreased body length 3.32735375811931e-22 8.71241312981241e-20 1.13253556997241 0.653284671532847 11.3 11 3 increased tumor incidence 7.44608757033063e-11 3.94088145344626e-09 1.13243352135375 0.653225806451613 11.3 11 3 decreased circulating creatinine level 4.13777412097837e-05 0.000623800795511133 1.13214820174645 0.653061224489796 11.3 11 3 abnormal bone structure 4.88968878597757e-16 6.23748761800985e-14 1.13178157344278 0.652849740932642 11.3 11 3 abnormal digit morphology 7.10559132323091e-07 1.79732291752237e-05 1.13165681797833 0.652777777777778 11.3 11 3 abnormal cell death 7.44924880739359e-05 0.00103713925895487 1.13060995690712 0.652173913043478 11.3 11 3 dilated heart 0.00493721230585795 0.0340202648499215 1.13060995690712 0.652173913043478 11.3 11 3 abnormal corneal stroma morphology 0.00493721230585795 0.0340202648499215 1.13060995690712 0.652173913043478 11.3 11 3 decreased effector memory CD8-positive, alpha-beta T cell number 0.00493721230585795 0.0340202648499215 1.13060995690712 0.652173913043478 11.3 11 3 prenatal lethality, incomplete penetrance 3.65013720653761e-24 1.06820191779556e-21 1.12912231222698 0.651315789473684 11.3 11 3 abnormal organ of Corti morphology 0.000134340132143045 0.00171810323242069 1.128857073253 0.651162790697674 11.3 11 3 abnormal homeostasis 0.000134340132143045 0.00171810323242069 1.128857073253 0.651162790697674 11.3 11 3 abnormal double-strand DNA break repair 0.000134340132143045 0.00171810323242069 1.128857073253 0.651162790697674 11.3 11 3 increased circulating aspartate transaminase level 4.04625685021612e-06 8.33840748122046e-05 1.1282171316015 0.650793650793651 11.3 11 3 intracranial hemorrhage 7.23707592498921e-06 0.000137733364123757 1.12684125705077 0.65 11.3 11 3 decreased circulating phosphate level 0.000242746051867736 0.00291002797118551 1.12684125705077 0.65 11.3 11 3 increased urine glucose level 0.0091799411486178 0.0534813193603255 1.12684125705077 0.65 11.3 11 3 abnormal trachea morphology 0.0091799411486178 0.0534813193603255 1.12684125705077 0.65 11.3 11 3 decreased myocardial infarction size 0.0091799411486178 0.0534813193603255 1.12684125705077 0.65 11.3 11 3 absent placental labyrinth 0.0091799411486178 0.0534813193603255 1.12684125705077 0.65 11.3 11 3 abnormal physiological neovascularization 0.0091799411486178 0.0534813193603255 1.12684125705077 0.65 11.3 11 3 abnormal postnatal subventricular zone morphology 0.0091799411486178 0.0534813193603255 1.12684125705077 0.65 11.3 11 3 increased urine calcium level 0.0091799411486178 0.0534813193603255 1.12684125705077 0.65 11.3 11 3 abnormal enzyme/coenzyme activity 4.57365622077045e-13 3.50060610743584e-11 1.12628915452404 0.64968152866242 11.3 11 3 decreased circulating glucose level 6.27248589389287e-22 1.43402523216177e-19 1.12466648759961 0.648745519713262 11.3 11 3 small spleen 4.07408305963208e-08 1.34228895507746e-06 1.1239836714454 0.648351648351648 11.3 11 3 abnormal osteoblast physiology 2.32190794736625e-05 0.000378737443873676 1.12363088309905 0.648148148148148 11.3 11 3 abnormal eye morphology 1.39934918954083e-11 8.19030849172425e-10 1.12247607232506 0.647482014388489 11.3 11 3 abnormal brown adipose tissue morphology 0.00079826342300347 0.00778698143027895 1.12174242783334 0.647058823529412 11.3 11 3 abnormal direction of heart looping 0.00079826342300347 0.00778698143027895 1.12174242783334 0.647058823529412 11.3 11 3 nephrocalcinosis 0.0172221778848746 0.0873209883788731 1.12174242783334 0.647058823529412 11.3 11 3 absence seizures 0.0172221778848746 0.0873209883788731 1.12174242783334 0.647058823529412 11.3 11 3 abnormal duodenum morphology 0.0172221778848746 0.0873209883788731 1.12174242783334 0.647058823529412 11.3 11 3 abnormal involuntary movement 0.0172221778848746 0.0873209883788731 1.12174242783334 0.647058823529412 11.3 11 3 coloboma 0.0172221778848746 0.0873209883788731 1.12174242783334 0.647058823529412 11.3 11 3 abnormal cell cytoskeleton morphology 0.0172221778848746 0.0873209883788731 1.12174242783334 0.647058823529412 11.3 11 3 abnormal osteoclast morphology 7.48408028069947e-05 0.00103713925895487 1.11961791565941 0.645833333333333 11.3 11 3 abnormal nervous system morphology 4.06564665247898e-07 1.07939737513924e-05 1.11916074215363 0.645569620253165 11.3 11 3 prenatal lethality 7.27907629486279e-06 0.000137733364123757 1.11845286059629 0.645161290322581 11.3 11 3 abnormal eyelid morphology 0.00145394649773853 0.0128418072111102 1.11845286059629 0.645161290322581 11.3 11 3 abnormal nose morphology 0.00145394649773853 0.0128418072111102 1.11845286059629 0.645161290322581 11.3 11 3 abnormal mitochondrial ATP synthesis coupled electron transport 0.00145394649773853 0.0128418072111102 1.11845286059629 0.645161290322581 11.3 11 3 abnormal thoracic vertebrae morphology 1.30088682352373e-05 0.000227884223486991 1.11655717778172 0.644067796610169 11.3 11 3 seminiferous tubule degeneration 1.28738276631222e-06 3.06581462626703e-05 1.11615466978685 0.643835616438356 11.3 11 3 decreased percent body fat/body weight 1.28738276631222e-06 3.06581462626703e-05 1.11615466978685 0.643835616438356 11.3 11 3 abnormal pancreas morphology 0.000242637789569921 0.00291002797118551 1.11445838609416 0.642857142857143 11.3 11 3 corneal vascularization 0.00265788932164871 0.0208821583297937 1.11445838609416 0.642857142857143 11.3 11 3 extended life span 0.0327026484081401 0.137877691381777 1.11445838609416 0.642857142857143 11.3 11 3 absent visceral yolk sac blood islands 0.0327026484081401 0.137877691381777 1.11445838609416 0.642857142857143 11.3 11 3 increased lactate dehydrogenase level 0.0327026484081401 0.137877691381777 1.11445838609416 0.642857142857143 11.3 11 3 amyloid beta deposits 0.0327026484081401 0.137877691381777 1.11445838609416 0.642857142857143 11.3 11 3 failure of zygotic cell division 0.0327026484081401 0.137877691381777 1.11445838609416 0.642857142857143 11.3 11 3 abnormal sagittal suture morphology 0.0327026484081401 0.137877691381777 1.11445838609416 0.642857142857143 11.3 11 3 abnormal decidualization 0.0327026484081401 0.137877691381777 1.11445838609416 0.642857142857143 11.3 11 3 abnormal viscerocranium morphology 0.0327026484081401 0.137877691381777 1.11445838609416 0.642857142857143 11.3 11 3 abnormal glucose tolerance 0.0327026484081401 0.137877691381777 1.11445838609416 0.642857142857143 11.3 11 3 spina bifida occulta 0.0327026484081401 0.137877691381777 1.11445838609416 0.642857142857143 11.3 11 3 pulmonary alveolar hemorrhage 0.0327026484081401 0.137877691381777 1.11445838609416 0.642857142857143 11.3 11 3 enlarged spleen 1.1686827770252e-21 2.52791165900017e-19 1.11359846449996 0.642361111111111 11.3 11 3 increased neuron apoptosis 4.07892877439554e-07 1.07939737513924e-05 1.11292963659335 0.641975308641975 11.3 11 3 thrombocytopenia 1.42800716850406e-11 8.26085542245082e-10 1.1118964127928 0.641379310344828 11.3 11 3 decreased caudal vertebrae number 7.28118085719558e-06 0.000137733364123757 1.11058873892023 0.640625 11.3 11 3 decreased rib number 1.2957723363143e-07 3.81447773559979e-06 1.11028438464812 0.640449438202247 11.3 11 3 enlarged liver 2.33028824014912e-08 8.40085796720424e-07 1.10950523771152 0.64 11.3 11 3 delayed bone ossification 1.28795026510514e-06 3.06581462626703e-05 1.10950523771152 0.64 11.3 11 3 abnormal hindlimb morphology 7.46663393829403e-05 0.00103713925895487 1.10950523771152 0.64 11.3 11 3 short stride length 7.46663393829403e-05 0.00103713925895487 1.10950523771152 0.64 11.3 11 3 abnormal thyroid gland morphology 0.00488019373367372 0.0339091673533893 1.10950523771152 0.64 11.3 11 3 diaphragmatic hernia 0.00488019373367372 0.0339091673533893 1.10950523771152 0.64 11.3 11 3 embryonic lethality during organogenesis, incomplete penetrance 3.15064538557792e-17 4.7498366040152e-15 1.10799775776898 0.639130434782609 11.3 11 3 abnormal axon morphology 7.44190369089693e-09 2.87003650094668e-07 1.1075790133405 0.638888888888889 11.3 11 3 hydrops fetalis 2.28987275718559e-06 5.04748360393878e-05 1.1075790133405 0.638888888888889 11.3 11 3 abnormal tibia morphology 0.0001339775740016 0.00171810323242069 1.1065544259091 0.638297872340426 11.3 11 3 spleen hypoplasia 1.31581940542438e-08 4.81338348675462e-07 1.10620313878976 0.638095238095238 11.3 11 3 glomerulosclerosis 2.31834917255449e-05 0.000378737443873676 1.10591847508961 0.637931034482759 11.3 11 3 thrombocytosis 2.31834917255449e-05 0.000378737443873676 1.10591847508961 0.637931034482759 11.3 11 3 hyperkeratosis 4.07283018680718e-06 8.33840748122046e-05 1.10548529119808 0.63768115942029 11.3 11 3 increased lymphocyte cell number 4.07283018680718e-06 8.33840748122046e-05 1.10548529119808 0.63768115942029 11.3 11 3 perimembraneous ventricular septal defect 4.07283018680718e-06 8.33840748122046e-05 1.10548529119808 0.63768115942029 11.3 11 3 abnormal retinal pigment epithelium morphology 7.23040739811105e-07 1.80760184952776e-05 1.10517123287671 0.6375 11.3 11 3 abnormal tail morphology 7.24713959786744e-06 0.000137733364123757 1.10320123067907 0.636363636363636 11.3 11 3 abnormal astrocyte morphology 0.000240714548025899 0.00289964861120787 1.10320123067907 0.636363636363636 11.3 11 3 dextrocardia 0.00143741492208968 0.0127922418661795 1.10320123067907 0.636363636363636 11.3 11 3 abnormal tail movements 0.0090091201334158 0.0534813193603255 1.10320123067907 0.636363636363636 11.3 11 3 intestinal inflammation 0.0090091201334158 0.0534813193603255 1.10320123067907 0.636363636363636 11.3 11 3 testis hypoplasia 0.0090091201334158 0.0534813193603255 1.10320123067907 0.636363636363636 11.3 11 3 aphakia 0.0090091201334158 0.0534813193603255 1.10320123067907 0.636363636363636 11.3 11 3 decreased cardiac output 0.0090091201334158 0.0534813193603255 1.10320123067907 0.636363636363636 11.3 11 3 prolonged PR interval 0.0090091201334158 0.0534813193603255 1.10320123067907 0.636363636363636 11.3 11 3 abnormal basement membrane morphology 0.0090091201334158 0.0534813193603255 1.10320123067907 0.636363636363636 11.3 11 3 increased mammary gland tumor incidence 0.0090091201334158 0.0534813193603255 1.10320123067907 0.636363636363636 11.3 11 3 increased bone volume 0.0090091201334158 0.0534813193603255 1.10320123067907 0.636363636363636 11.3 11 3 decreased atrioventricular cushion size 0.0631742075236693 0.218295389972812 1.10320123067907 0.636363636363636 11.3 11 3 abnormal hemoglobin 0.0631742075236693 0.218295389972812 1.10320123067907 0.636363636363636 11.3 11 3 focal hepatic necrosis 0.0631742075236693 0.218295389972812 1.10320123067907 0.636363636363636 11.3 11 3 secondary sex reversal 0.0631742075236693 0.218295389972812 1.10320123067907 0.636363636363636 11.3 11 3 abnormal bronchiole morphology 0.0631742075236693 0.218295389972812 1.10320123067907 0.636363636363636 11.3 11 3 retinal detachment 0.0631742075236693 0.218295389972812 1.10320123067907 0.636363636363636 11.3 11 3 patent ductus arteriosus 0.0631742075236693 0.218295389972812 1.10320123067907 0.636363636363636 11.3 11 3 fused joints 0.0631742075236693 0.218295389972812 1.10320123067907 0.636363636363636 11.3 11 3 increased circulating triiodothyronine level 0.0631742075236693 0.218295389972812 1.10320123067907 0.636363636363636 11.3 11 3 abnormal aorta smooth muscle morphology 0.0631742075236693 0.218295389972812 1.10320123067907 0.636363636363636 11.3 11 3 abnormal pulmonary alveolar sac morphology 0.0631742075236693 0.218295389972812 1.10320123067907 0.636363636363636 11.3 11 3 decreased embryonic cilium length 0.0631742075236693 0.218295389972812 1.10320123067907 0.636363636363636 11.3 11 3 abnormal angiogenesis 2.27736325383277e-06 5.04748360393878e-05 1.10107149857351 0.635135135135135 11.3 11 3 abnormal intestine morphology 2.27736325383277e-06 5.04748360393878e-05 1.10107149857351 0.635135135135135 11.3 11 3 anemia 1.64912167868949e-15 1.9079954305768e-13 1.10096046988555 0.635071090047393 11.3 11 3 hemopericardium 0.000433114389909281 0.00473570129626082 1.09935732395197 0.634146341463415 11.3 11 3 increased bone trabecula number 0.000433114389909281 0.00473570129626082 1.09935732395197 0.634146341463415 11.3 11 3 cleft palate 4.28299981708e-10 1.99139477476383e-08 1.09838901157033 0.633587786259542 11.3 11 3 epidermal hyperplasia 2.29783276802114e-05 0.000378533709301495 1.09794789148536 0.633333333333333 11.3 11 3 abnormal behavior 1.07987404696141e-19 2.14894935345322e-17 1.09753215960672 0.633093525179856 11.3 11 3 abnormal renal glomerulus morphology 1.30298574591762e-08 4.80174376736309e-07 1.09741773798875 0.63302752293578 11.3 11 3 decreased birth weight 1.2757301522205e-07 3.77783184958154e-06 1.09490648458374 0.631578947368421 11.3 11 3 incomplete somite formation 0.00078056865795518 0.00778222259183772 1.09490648458374 0.631578947368421 11.3 11 3 small superior vagus ganglion 0.0167443301812876 0.0873209883788731 1.09490648458374 0.631578947368421 11.3 11 3 thin dermal layer 0.0167443301812876 0.0873209883788731 1.09490648458374 0.631578947368421 11.3 11 3 abnormal long term depression 0.0167443301812876 0.0873209883788731 1.09490648458374 0.631578947368421 11.3 11 3 decreased tumor incidence 0.0167443301812876 0.0873209883788731 1.09490648458374 0.631578947368421 11.3 11 3 abnormal neural crest cell migration 0.0167443301812876 0.0873209883788731 1.09490648458374 0.631578947368421 11.3 11 3 absent amnion 0.0167443301812876 0.0873209883788731 1.09490648458374 0.631578947368421 11.3 11 3 decreased eye pigmentation 0.0167443301812876 0.0873209883788731 1.09490648458374 0.631578947368421 11.3 11 3 decreased susceptibility to weight gain 0.0167443301812876 0.0873209883788731 1.09490648458374 0.631578947368421 11.3 11 3 abnormal craniofacial morphology 4.05457634272592e-08 1.34228895507746e-06 1.09402063791336 0.631067961165049 11.3 11 3 hydronephrosis 7.11703748245041e-07 1.79732291752237e-05 1.09382026783316 0.630952380952381 11.3 11 3 abnormal myelin sheath morphology 0.000237260902665438 0.0028649829872829 1.09292295834355 0.630434782608696 11.3 11 3 atrial septal defect 0.000237260902665438 0.0028649829872829 1.09292295834355 0.630434782608696 11.3 11 3 abnormal chondrocyte morphology 7.30104632121388e-05 0.00103080250535724 1.09152714358194 0.62962962962963 11.3 11 3 abnormal mandible morphology 7.30104632121388e-05 0.00103080250535724 1.09152714358194 0.62962962962963 11.3 11 3 neurodegeneration 7.30104632121388e-05 0.00103080250535724 1.09152714358194 0.62962962962963 11.3 11 3 abnormal cell adhesion 7.30104632121388e-05 0.00103080250535724 1.09152714358194 0.62962962962963 11.3 11 3 decreased platelet aggregation 7.30104632121388e-05 0.00103080250535724 1.09152714358194 0.62962962962963 11.3 11 3 abnormal kidney morphology 1.4277275263858e-12 1.04027467940078e-10 1.08969264418096 0.628571428571429 11.3 11 3 abnormal blood circulation 0.000425390086477775 0.00470292373383762 1.08854074920825 0.627906976744186 11.3 11 3 abnormal dendritic spine morphology 0.000130257159413376 0.00169641195832865 1.08775023305051 0.627450980392157 11.3 11 3 internal hemorrhage 1.25605270931052e-05 0.000222379438748037 1.08673554066894 0.626865671641791 11.3 11 3 spleen hyperplasia 3.93816362776842e-06 8.19764186114974e-05 1.0863905452592 0.626666666666667 11.3 11 3 decreased circulating LDL cholesterol level 2.22683545212203e-05 0.000370518607836357 1.08350120870266 0.625 11.3 11 3 abnormal osteoclast physiology 2.22683545212203e-05 0.000370518607836357 1.08350120870266 0.625 11.3 11 3 abnormal tooth morphology 2.22683545212203e-05 0.000370518607836357 1.08350120870266 0.625 11.3 11 3 abnormal eye development 7.16524130652853e-05 0.00102729324207433 1.08350120870266 0.625 11.3 11 3 overriding aortic valve 0.000232538859325937 0.00283549221849642 1.08350120870266 0.625 11.3 11 3 abnormal digestive system morphology 0.00874219182760053 0.0528461778156897 1.08350120870266 0.625 11.3 11 3 decreased metastatic potential 0.00874219182760053 0.0528461778156897 1.08350120870266 0.625 11.3 11 3 abnormal primitive streak formation 0.00874219182760053 0.0528461778156897 1.08350120870266 0.625 11.3 11 3 vasculature congestion 0.0313935627418492 0.135198032048925 1.08350120870266 0.625 11.3 11 3 abnormal hair follicle orientation 0.0313935627418492 0.135198032048925 1.08350120870266 0.625 11.3 11 3 disorganized retinal layers 0.0313935627418492 0.135198032048925 1.08350120870266 0.625 11.3 11 3 poor circulation 0.0313935627418492 0.135198032048925 1.08350120870266 0.625 11.3 11 3 disorganized yolk sac vascular plexus 0.0313935627418492 0.135198032048925 1.08350120870266 0.625 11.3 11 3 increased intestinal adenocarcinoma incidence 0.0313935627418492 0.135198032048925 1.08350120870266 0.625 11.3 11 3 abnormal epicardium morphology 0.0313935627418492 0.135198032048925 1.08350120870266 0.625 11.3 11 3 large intestinal inflammation 0.0313935627418492 0.135198032048925 1.08350120870266 0.625 11.3 11 3 increased pancreatic beta cell number 0.0313935627418492 0.135198032048925 1.08350120870266 0.625 11.3 11 3 increased thymus weight 0.0313935627418492 0.135198032048925 1.08350120870266 0.625 11.3 11 3 kidney degeneration 0.0313935627418492 0.135198032048925 1.08350120870266 0.625 11.3 11 3 decreased liver cholesterol level 0.0313935627418492 0.135198032048925 1.08350120870266 0.625 11.3 11 3 abnormal ear pigmentation 0.125303485712766 0.339666734471754 1.08350120870266 0.625 11.3 11 3 abnormal exoccipital bone morphology 0.125303485712766 0.339666734471754 1.08350120870266 0.625 11.3 11 3 schistocytosis 0.125303485712766 0.339666734471754 1.08350120870266 0.625 11.3 11 3 increased sensitivity to skin irradiation 0.125303485712766 0.339666734471754 1.08350120870266 0.625 11.3 11 3 dermal cysts 0.125303485712766 0.339666734471754 1.08350120870266 0.625 11.3 11 3 dry eyes 0.125303485712766 0.339666734471754 1.08350120870266 0.625 11.3 11 3 absent eyelids 0.125303485712766 0.339666734471754 1.08350120870266 0.625 11.3 11 3 abnormal erythrocyte cell number 0.125303485712766 0.339666734471754 1.08350120870266 0.625 11.3 11 3 abnormal neuron apoptosis 0.125303485712766 0.339666734471754 1.08350120870266 0.625 11.3 11 3 decreased susceptibility to age related obesity 0.125303485712766 0.339666734471754 1.08350120870266 0.625 11.3 11 3 loss of GABAergic neurons 0.125303485712766 0.339666734471754 1.08350120870266 0.625 11.3 11 3 abnormal perineum morphology 0.125303485712766 0.339666734471754 1.08350120870266 0.625 11.3 11 3 liver failure 0.125303485712766 0.339666734471754 1.08350120870266 0.625 11.3 11 3 increased left ventricle systolic pressure 0.125303485712766 0.339666734471754 1.08350120870266 0.625 11.3 11 3 abnormal skin development 0.125303485712766 0.339666734471754 1.08350120870266 0.625 11.3 11 3 abnormal miscarriage rate 0.125303485712766 0.339666734471754 1.08350120870266 0.625 11.3 11 3 non-pigmented tail tip 0.125303485712766 0.339666734471754 1.08350120870266 0.625 11.3 11 3 abnormal somite size 0.125303485712766 0.339666734471754 1.08350120870266 0.625 11.3 11 3 abnormal ilium morphology 0.125303485712766 0.339666734471754 1.08350120870266 0.625 11.3 11 3 hypergranulosis 0.125303485712766 0.339666734471754 1.08350120870266 0.625 11.3 11 3 abnormal mitotic spindle assembly checkpoint 0.125303485712766 0.339666734471754 1.08350120870266 0.625 11.3 11 3 skin fibrosis 0.125303485712766 0.339666734471754 1.08350120870266 0.625 11.3 11 3 abnormal olfactory bulb glomerular layer morphology 0.125303485712766 0.339666734471754 1.08350120870266 0.625 11.3 11 3 abnormal brain ependyma morphology 0.125303485712766 0.339666734471754 1.08350120870266 0.625 11.3 11 3 myocardial trabeculae hypoplasia 0.125303485712766 0.339666734471754 1.08350120870266 0.625 11.3 11 3 delayed suture closure 0.125303485712766 0.339666734471754 1.08350120870266 0.625 11.3 11 3 abnormal heart right ventricle pressure 0.125303485712766 0.339666734471754 1.08350120870266 0.625 11.3 11 3 abnormal maxillary prominence morphology 0.125303485712766 0.339666734471754 1.08350120870266 0.625 11.3 11 3 abnormal bronchus epithelium morphology 0.125303485712766 0.339666734471754 1.08350120870266 0.625 11.3 11 3 absent ureteric bud 0.125303485712766 0.339666734471754 1.08350120870266 0.625 11.3 11 3 decreased surfactant secretion 0.125303485712766 0.339666734471754 1.08350120870266 0.625 11.3 11 3 increased aorta wall thickness 0.125303485712766 0.339666734471754 1.08350120870266 0.625 11.3 11 3 lethality during fetal growth through weaning, incomplete penetrance 0.125303485712766 0.339666734471754 1.08350120870266 0.625 11.3 11 3 impaired neuron differentiation 0.125303485712766 0.339666734471754 1.08350120870266 0.625 11.3 11 3 abnormal heart echocardiography feature 0.125303485712766 0.339666734471754 1.08350120870266 0.625 11.3 11 3 prolonged PQ interval 0.125303485712766 0.339666734471754 1.08350120870266 0.625 11.3 11 3 absent hypoglossal canal 0.125303485712766 0.339666734471754 1.08350120870266 0.625 11.3 11 3 retropleural edema 0.125303485712766 0.339666734471754 1.08350120870266 0.625 11.3 11 3 abnormal vertebrae morphology 3.88776138709195e-08 1.31079805271838e-06 1.08151313309036 0.623853211009174 11.3 11 3 lethargy 3.85431617598147e-07 1.03649853921664e-05 1.08117109857642 0.623655913978495 11.3 11 3 cardiac fibrosis 1.21855149806009e-06 2.94286102080046e-05 1.08095179409395 0.623529411764706 11.3 11 3 abnormal sternum morphology 1.23207563504175e-05 0.000218913438726167 1.08036062548903 0.623188405797101 11.3 11 3 abnormal long bone morphology 3.94840145497902e-05 0.000611583953151631 1.07994874572331 0.622950819672131 11.3 11 3 increased granulocyte number 6.82428113297556e-06 0.000132620307174037 1.07764444541237 0.621621621621622 11.3 11 3 increased circulating phosphate level 0.00137234592556476 0.0123238645842684 1.07764444541237 0.621621621621622 11.3 11 3 decreased width of hypertrophic chondrocyte zone 0.00137234592556476 0.0123238645842684 1.07764444541237 0.621621621621622 11.3 11 3 alopecia 3.77829479793626e-07 1.02157699020288e-05 1.07665804317401 0.621052631578947 11.3 11 3 preweaning lethality, incomplete penetrance 5.87341566668856e-26 2.08716021012683e-23 1.07661342595785 0.621026894865526 11.3 11 3 dermatitis 7.00164059281321e-05 0.00100673878466028 1.07602878657368 0.620689655172414 11.3 11 3 lordosis 0.00462472766104104 0.0332485839793051 1.07602878657368 0.620689655172414 11.3 11 3 decreased leukocyte cell number 1.21724955279135e-09 5.22053148718706e-08 1.07559244075592 0.62043795620438 11.3 11 3 kyphosis 2.18367650202638e-10 1.06507750956679e-08 1.07483319903304 0.62 11.3 11 3 kidney inflammation 0.000226785528147056 0.00279271782804852 1.07483319903304 0.62 11.3 11 3 abnormal bone mineralization 1.19163144159435e-08 4.42415404621783e-07 1.07454665325884 0.619834710743802 11.3 11 3 increased circulating free fatty acid level 1.20437419683307e-05 0.00021475848133493 1.0743448604601 0.619718309859155 11.3 11 3 gliosis 3.8539995962893e-05 0.000601054795973018 1.07318214957216 0.619047619047619 11.3 11 3 abnormal reproductive system morphology 0.000742638865460742 0.00750940722696583 1.07318214957216 0.619047619047619 11.3 11 3 trunk curl 0.0160952973917632 0.0863798322804984 1.07318214957216 0.619047619047619 11.3 11 3 abnormal erythrocyte physiology 0.0160952973917632 0.0863798322804984 1.07318214957216 0.619047619047619 11.3 11 3 abnormal clavicle morphology 0.0160952973917632 0.0863798322804984 1.07318214957216 0.619047619047619 11.3 11 3 abnormal tumor vascularization 0.0160952973917632 0.0863798322804984 1.07318214957216 0.619047619047619 11.3 11 3 reduced fertility 1.19172774706163e-09 5.15551786228837e-08 1.07258824688839 0.618705035971223 11.3 11 3 abnormal rostral-caudal axis patterning 0.000124168735134959 0.00163856619972525 1.07168119551681 0.618181818181818 11.3 11 3 pericardial edema 2.12509453003457e-05 0.000358384585997356 1.0707541356591 0.617647058823529 11.3 11 3 abnormal retinal photoreceptor morphology 0.00246989042061356 0.0198946465605486 1.0707541356591 0.617647058823529 11.3 11 3 decreased heart weight 3.69202279321539e-06 7.71756865388511e-05 1.07012465057053 0.617283950617284 11.3 11 3 decreased bone marrow cell number 1.17356739782538e-05 0.000211020109768135 1.06865872639166 0.616438356164384 11.3 11 3 ventricular hypoplasia 0.00841049450760679 0.0517209025653199 1.066831959338 0.615384615384615 11.3 11 3 abnormal kidney cortex morphology 0.00841049450760679 0.0517209025653199 1.066831959338 0.615384615384615 11.3 11 3 increased leukemia incidence 0.00841049450760679 0.0517209025653199 1.066831959338 0.615384615384615 11.3 11 3 abnormal nerve conduction 0.00841049450760679 0.0517209025653199 1.066831959338 0.615384615384615 11.3 11 3 short premaxilla 0.0595476391904454 0.215341384263885 1.066831959338 0.615384615384615 11.3 11 3 absent common myeloid progenitor cells 0.0595476391904454 0.215341384263885 1.066831959338 0.615384615384615 11.3 11 3 absent trabeculae carneae 0.0595476391904454 0.215341384263885 1.066831959338 0.615384615384615 11.3 11 3 pup cannibalization 0.0595476391904454 0.215341384263885 1.066831959338 0.615384615384615 11.3 11 3 abnormal lung interstitium morphology 0.0595476391904454 0.215341384263885 1.066831959338 0.615384615384615 11.3 11 3 anal atresia 0.0595476391904454 0.215341384263885 1.066831959338 0.615384615384615 11.3 11 3 abnormal vertebral arch development 0.0595476391904454 0.215341384263885 1.066831959338 0.615384615384615 11.3 11 3 increased renin activity 0.0595476391904454 0.215341384263885 1.066831959338 0.615384615384615 11.3 11 3 abnormal spermatogenesis 6.43380489205544e-12 4.11511506418051e-10 1.06465770942087 0.614130434782609 11.3 11 3 incomplete embryo turning 0.000120500819322088 0.00159547907412915 1.06449241556752 0.614035087719298 11.3 11 3 abnormal heart development 1.98755044904459e-10 9.88806348399681e-09 1.06429992145983 0.613924050632911 11.3 11 3 decreased body weight 9.87701277674907e-73 2.45690692821633e-69 1.06424674457386 0.61389337641357 11.3 11 3 abnormal myelopoiesis 0.000718698294607228 0.00729698778708359 1.06380118672625 0.613636363636364 11.3 11 3 embryonic lethality, incomplete penetrance 0.000718698294607228 0.00729698778708359 1.06380118672625 0.613636363636364 11.3 11 3 abnormal capillary morphology 0.00445189560471258 0.0323331104137884 1.06253021756648 0.612903225806452 11.3 11 3 abnormal podocyte morphology 0.00445189560471258 0.0323331104137884 1.06253021756648 0.612903225806452 11.3 11 3 small cranium 0.00445189560471258 0.0323331104137884 1.06253021756648 0.612903225806452 11.3 11 3 abnormal definitive hematopoiesis 1.10474967002312e-06 2.69353062595668e-05 1.06253021756648 0.612903225806452 11.3 11 3 decreased bone mineral density 2.10676777204057e-16 2.83274855835184e-14 1.06231998206637 0.612781954887218 11.3 11 3 increased T cell derived lymphoma incidence 0.000390539745977469 0.0043858583210788 1.0613889391373 0.612244897959184 11.3 11 3 increased heart weight 3.35816669636571e-09 1.36941633724749e-07 1.06011629052922 0.611510791366906 11.3 11 3 thin ventricular wall 1.93246305520483e-06 4.43041645144886e-05 1.05942340406482 0.611111111111111 11.3 11 3 abnormal long bone epiphyseal plate proliferative zone 0.000213006477595745 0.00262954646659759 1.05942340406482 0.611111111111111 11.3 11 3 abnormal uterus morphology 0.00237862007524792 0.0194669114941458 1.05942340406482 0.611111111111111 11.3 11 3 abnormal limb bone morphology 0.00237862007524792 0.0194669114941458 1.05942340406482 0.611111111111111 11.3 11 3 lowered ear position 0.0298084029283769 0.133721194381132 1.05942340406482 0.611111111111111 11.3 11 3 abnormal megakaryocyte differentiation 0.0298084029283769 0.133721194381132 1.05942340406482 0.611111111111111 11.3 11 3 abnormal radius morphology 0.0298084029283769 0.133721194381132 1.05942340406482 0.611111111111111 11.3 11 3 abnormal mammary gland morphology 0.0298084029283769 0.133721194381132 1.05942340406482 0.611111111111111 11.3 11 3 absent ureter 0.0298084029283769 0.133721194381132 1.05942340406482 0.611111111111111 11.3 11 3 long tibia 0.0298084029283769 0.133721194381132 1.05942340406482 0.611111111111111 11.3 11 3 darkened coat color 0.0298084029283769 0.133721194381132 1.05942340406482 0.611111111111111 11.3 11 3 jerky movement 0.0298084029283769 0.133721194381132 1.05942340406482 0.611111111111111 11.3 11 3 increased gastrointestinal tumor incidence 0.0298084029283769 0.133721194381132 1.05942340406482 0.611111111111111 11.3 11 3 decreased tumor latency 0.0298084029283769 0.133721194381132 1.05942340406482 0.611111111111111 11.3 11 3 atrioventricular block 0.0298084029283769 0.133721194381132 1.05942340406482 0.611111111111111 11.3 11 3 primary atelectasis 0.0298084029283769 0.133721194381132 1.05942340406482 0.611111111111111 11.3 11 3 polyuria 1.10487160315903e-05 0.000200161756304237 1.0581726090187 0.61038961038961 11.3 11 3 azoospermia 3.26725503482754e-10 1.56294171137183e-08 1.05760621126197 0.610062893081761 11.3 11 3 abnormal lens morphology 1.82204851920401e-08 6.61656305331383e-07 1.05641367848509 0.609375 11.3 11 3 increased sacral vertebrae number 6.39237566119021e-05 0.00092988505597723 1.05641367848509 0.609375 11.3 11 3 abnormal ulna morphology 0.0153431989762836 0.0829700162032728 1.05523595977998 0.608695652173913 11.3 11 3 thymus hypoplasia 5.66469152919006e-09 2.25454722861764e-07 1.05523595977998 0.608695652173913 11.3 11 3 postnatal growth retardation 1.46882948768077e-34 9.13428337651478e-32 1.05375803826768 0.607843137254902 11.3 11 3 kinked tail 5.75829435916343e-07 1.48432717289316e-05 1.05375803826768 0.607843137254902 11.3 11 3 abnormal cervical vertebrae morphology 0.00037640449968426 0.00424628658940861 1.05375803826768 0.607843137254902 11.3 11 3 hunched posture 1.06797613995093e-05 0.000196058350415346 1.05332775732107 0.607594936708861 11.3 11 3 premature death 4.3797609704174e-48 4.35786216556532e-45 1.05304740004923 0.607433217189315 11.3 11 3 abnormal coat/hair pigmentation 1.77772578130406e-07 5.08286538045269e-06 1.05254403131115 0.607142857142857 11.3 11 3 abnormal jaw morphology 0.00803737389778385 0.0499824189268433 1.05254403131115 0.607142857142857 11.3 11 3 reddish skin 0.00803737389778385 0.0499824189268433 1.05254403131115 0.607142857142857 11.3 11 3 absent corpus callosum 0.00803737389778385 0.0499824189268433 1.05254403131115 0.607142857142857 11.3 11 3 failure of blastocyst to hatch from the zona pellucida 0.00803737389778385 0.0499824189268433 1.05254403131115 0.607142857142857 11.3 11 3 hypoxia 0.00803737389778385 0.0499824189268433 1.05254403131115 0.607142857142857 11.3 11 3 belly spot 0.00426159790195029 0.031087169446045 1.05066783874197 0.606060606060606 11.3 11 3 single kidney 0.00426159790195029 0.031087169446045 1.05066783874197 0.606060606060606 11.3 11 3 increased osteoblast cell number 0.00426159790195029 0.031087169446045 1.05066783874197 0.606060606060606 11.3 11 3 myeloid hyperplasia 0.00426159790195029 0.031087169446045 1.05066783874197 0.606060606060606 11.3 11 3 atelectasis 3.38870459079576e-05 0.000531823512277883 1.04992793181328 0.605633802816901 11.3 11 3 abnormal axial skeleton morphology 1.86667211224224e-05 0.000321338884373881 1.04928538105942 0.605263157894737 11.3 11 3 increased oxygen consumption 5.69122468892113e-06 0.000114630942620982 1.0482244251635 0.604651162790698 11.3 11 3 abnormal vasculogenesis 0.00122784288037586 0.0113330581259182 1.0482244251635 0.604651162790698 11.3 11 3 delayed endochondral bone ossification 0.00122784288037586 0.0113330581259182 1.0482244251635 0.604651162790698 11.3 11 3 curly tail 0.000664849499517129 0.00681984795896437 1.0473845017459 0.604166666666667 11.3 11 3 thymus atrophy 0.000664849499517129 0.00681984795896437 1.0473845017459 0.604166666666667 11.3 11 3 abnormal coat/ hair morphology 0.00036155981464811 0.00409740336645637 1.04670305444483 0.60377358490566 11.3 11 3 decreased circulating alanine transaminase level 5.92740198257526e-05 0.000867318378332704 1.04525998957198 0.602941176470588 11.3 11 3 decreased body size 5.46113345300109e-43 3.88130556124006e-40 1.0449405140571 0.602756892230576 11.3 11 3 short tail 9.91211741150582e-06 0.000182639941193487 1.0443385144122 0.602409638554217 11.3 11 3 increased spleen weight 2.87060344372764e-07 7.80396291395903e-06 1.0432294823615 0.601769911504425 11.3 11 3 abnormal rib morphology 2.64595176896205e-08 9.47022305797568e-07 1.04016116035455 0.6 11.3 11 3 abnormal limb morphology 3.12886110818436e-05 0.000498912949141577 1.04016116035455 0.6 11.3 11 3 decreased oocyte number 0.000636171072723085 0.00656148142097419 1.04016116035455 0.6 11.3 11 3 abnormal cell migration 0.00117362228812519 0.0109135904363043 1.04016116035455 0.6 11.3 11 3 small placenta 0.00117362228812519 0.0109135904363043 1.04016116035455 0.6 11.3 11 3 abnormal metabolism 0.00117362228812519 0.0109135904363043 1.04016116035455 0.6 11.3 11 3 ovary cysts 0.00406069827288334 0.0300177918389221 1.04016116035455 0.6 11.3 11 3 increased carcinoma incidence 0.00406069827288334 0.0300177918389221 1.04016116035455 0.6 11.3 11 3 holoprosencephaly 0.00406069827288334 0.0300177918389221 1.04016116035455 0.6 11.3 11 3 abnormal hippocampus pyramidal cell morphology 0.00406069827288334 0.0300177918389221 1.04016116035455 0.6 11.3 11 3 decreased bone volume 0.00406069827288334 0.0300177918389221 1.04016116035455 0.6 11.3 11 3 impaired adaptive thermogenesis 0.00406069827288334 0.0300177918389221 1.04016116035455 0.6 11.3 11 3 decreased bone mineralization 0.00406069827288334 0.0300177918389221 1.04016116035455 0.6 11.3 11 3 abnormal heart tube morphology 0.00764015476323568 0.0488557454332873 1.04016116035455 0.6 11.3 11 3 delayed eyelid opening 0.00764015476323568 0.0488557454332873 1.04016116035455 0.6 11.3 11 3 abnormal lactation 0.00764015476323568 0.0488557454332873 1.04016116035455 0.6 11.3 11 3 enhanced paired-pulse facilitation 0.00764015476323568 0.0488557454332873 1.04016116035455 0.6 11.3 11 3 ruffled hair 0.0145351889684908 0.0792016295406067 1.04016116035455 0.6 11.3 11 3 abnormal nest building behavior 0.0145351889684908 0.0792016295406067 1.04016116035455 0.6 11.3 11 3 abnormal keratinocyte physiology 0.0145351889684908 0.0792016295406067 1.04016116035455 0.6 11.3 11 3 abnormal vertebrae development 0.0145351889684908 0.0792016295406067 1.04016116035455 0.6 11.3 11 3 decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 0.0145351889684908 0.0792016295406067 1.04016116035455 0.6 11.3 11 3 absent incisors 0.0556115349683982 0.204120830896894 1.04016116035455 0.6 11.3 11 3 decreased chondrocyte number 0.0556115349683982 0.204120830896894 1.04016116035455 0.6 11.3 11 3 abnormal epidermis stratum spinosum morphology 0.0556115349683982 0.204120830896894 1.04016116035455 0.6 11.3 11 3 abnormal apical ectodermal ridge morphology 0.0556115349683982 0.204120830896894 1.04016116035455 0.6 11.3 11 3 abnormal cricoid cartilage morphology 0.0556115349683982 0.204120830896894 1.04016116035455 0.6 11.3 11 3 abnormal lymph node B cell domain morphology 0.0556115349683982 0.204120830896894 1.04016116035455 0.6 11.3 11 3 dilated ureter 0.0556115349683982 0.204120830896894 1.04016116035455 0.6 11.3 11 3 abnormal ear development 0.0556115349683982 0.204120830896894 1.04016116035455 0.6 11.3 11 3 absent chorion 0.0556115349683982 0.204120830896894 1.04016116035455 0.6 11.3 11 3 abnormal aorta wall morphology 0.0556115349683982 0.204120830896894 1.04016116035455 0.6 11.3 11 3 ostium primum atrial septal defect 0.0556115349683982 0.204120830896894 1.04016116035455 0.6 11.3 11 3 abnormal coronary vessel morphology 0.0556115349683982 0.204120830896894 1.04016116035455 0.6 11.3 11 3 herniated liver 0.0556115349683982 0.204120830896894 1.04016116035455 0.6 11.3 11 3 abnormal testis morphology 2.76066463577216e-07 7.63017031275918e-06 1.04016116035455 0.6 11.3 11 3 abnormal basioccipital bone morphology 0.0280909137302924 0.127627667404753 1.04016116035455 0.6 11.3 11 3 small gonad 0.0280909137302924 0.127627667404753 1.04016116035455 0.6 11.3 11 3 spleen atrophy 0.0280909137302924 0.127627667404753 1.04016116035455 0.6 11.3 11 3 abnormal response to tactile stimuli 0.0280909137302924 0.127627667404753 1.04016116035455 0.6 11.3 11 3 abnormal sperm mitochondrial sheath morphology 0.0280909137302924 0.127627667404753 1.04016116035455 0.6 11.3 11 3 retarded hair growth 0.114798664501896 0.338343220318087 1.04016116035455 0.6 11.3 11 3 enlarged testis 0.114798664501896 0.338343220318087 1.04016116035455 0.6 11.3 11 3 decreased circulating parathyroid hormone level 0.114798664501896 0.338343220318087 1.04016116035455 0.6 11.3 11 3 primary sex reversal 0.114798664501896 0.338343220318087 1.04016116035455 0.6 11.3 11 3 rickets 0.114798664501896 0.338343220318087 1.04016116035455 0.6 11.3 11 3 abnormal submandibular gland morphology 0.114798664501896 0.338343220318087 1.04016116035455 0.6 11.3 11 3 increased atrioventricular cushion size 0.114798664501896 0.338343220318087 1.04016116035455 0.6 11.3 11 3 absent pharyngeal arches 0.114798664501896 0.338343220318087 1.04016116035455 0.6 11.3 11 3 abnormal ear physiology 0.114798664501896 0.338343220318087 1.04016116035455 0.6 11.3 11 3 abnormal utricular macula morphology 0.114798664501896 0.338343220318087 1.04016116035455 0.6 11.3 11 3 abnormal respiratory conducting tube morphology 0.114798664501896 0.338343220318087 1.04016116035455 0.6 11.3 11 3 osteosclerosis 0.114798664501896 0.338343220318087 1.04016116035455 0.6 11.3 11 3 decreased thyroxine level 0.114798664501896 0.338343220318087 1.04016116035455 0.6 11.3 11 3 increased circulating fructosamine level 0.114798664501896 0.338343220318087 1.04016116035455 0.6 11.3 11 3 abnormal retinal blood vessel pattern 0.114798664501896 0.338343220318087 1.04016116035455 0.6 11.3 11 3 increased kidney iron level 0.114798664501896 0.338343220318087 1.04016116035455 0.6 11.3 11 3 abnormal heart and great artery attachment 0.114798664501896 0.338343220318087 1.04016116035455 0.6 11.3 11 3 aorta stenosis 0.114798664501896 0.338343220318087 1.04016116035455 0.6 11.3 11 3 thin ventricle myocardium compact layer 0.114798664501896 0.338343220318087 1.04016116035455 0.6 11.3 11 3 abnormal pulmonary interalveolar septum morphology 0.114798664501896 0.338343220318087 1.04016116035455 0.6 11.3 11 3 decreased trabecular bone connectivity density 0.114798664501896 0.338343220318087 1.04016116035455 0.6 11.3 11 3 reduced female fertility 3.96254445848991e-13 3.12915217158529e-11 1.03866667592876 0.599137931034483 11.3 11 3 abnormal myocardial fiber morphology 2.79487435689488e-06 5.9933189334276e-05 1.03658672337739 0.597938144329897 11.3 11 3 abnormal spleen morphology 4.10344199043102e-10 1.92590791532022e-08 1.03617586855243 0.597701149425287 11.3 11 3 abnormal craniofacial bone morphology 0.000330730460824786 0.0037912074714362 1.03407834655131 0.596491228070175 11.3 11 3 pulmonary hypoplasia 0.0011182681029946 0.0104574883691694 1.03278413084849 0.595744680851064 11.3 11 3 abnormal retina morphology 1.10316652721993e-11 6.69299204014528e-10 1.03190591305015 0.595238095238095 11.3 11 3 disheveled coat 0.0020700254163977 0.017454875333184 1.03190591305015 0.595238095238095 11.3 11 3 spina bifida 0.0020700254163977 0.017454875333184 1.03190591305015 0.595238095238095 11.3 11 3 abnormal long bone metaphysis morphology 0.00385448882811654 0.0290107139483809 1.0307903390901 0.594594594594595 11.3 11 3 abnormal vocalization 0.00385448882811654 0.0290107139483809 1.0307903390901 0.594594594594595 11.3 11 3 skin inflammation 0.00385448882811654 0.0290107139483809 1.0307903390901 0.594594594594595 11.3 11 3 abnormal vertebral body morphology 0.00723163031795032 0.0467238452361076 1.02932614826753 0.59375 11.3 11 3 abnormal lymphatic vessel morphology 0.00723163031795032 0.0467238452361076 1.02932614826753 0.59375 11.3 11 3 short snout 1.35764799422297e-06 3.21633274821871e-05 1.02731966454771 0.592592592592593 11.3 11 3 abnormal skeleton development 2.7349179457104e-05 0.000441760285061988 1.02731966454771 0.592592592592593 11.3 11 3 abnormal maxilla morphology 0.000577637395815186 0.00606275536746952 1.02731966454771 0.592592592592593 11.3 11 3 abnormal apoptosis 0.000577637395815186 0.00606275536746952 1.02731966454771 0.592592592592593 11.3 11 3 abnormal trigeminal ganglion morphology 0.0137039290462738 0.0757522744502357 1.02731966454771 0.592592592592593 11.3 11 3 thick interventricular septum 0.0137039290462738 0.0757522744502357 1.02731966454771 0.592592592592593 11.3 11 3 increased circulating LDL cholesterol level 0.00106259864214965 0.00997439291451791 1.02600930783272 0.591836734693878 11.3 11 3 absent kidney 0.00106259864214965 0.00997439291451791 1.02600930783272 0.591836734693878 11.3 11 3 abnormal respiratory system physiology 0.00106259864214965 0.00997439291451791 1.02600930783272 0.591836734693878 11.3 11 3 increased fluid intake 0.00106259864214965 0.00997439291451791 1.02600930783272 0.591836734693878 11.3 11 3 abnormal skeleton morphology 7.20071910950299e-07 1.80760184952776e-05 1.02508636092912 0.591304347826087 11.3 11 3 omphalocele 0.00196327394870835 0.0167534955314306 1.02440114277342 0.590909090909091 11.3 11 3 abnormal long bone epiphysis morphology 0.0263308867649317 0.123697980788985 1.02440114277342 0.590909090909091 11.3 11 3 abnormal enterocyte morphology 0.0263308867649317 0.123697980788985 1.02440114277342 0.590909090909091 11.3 11 3 increased body size 0.0263308867649317 0.123697980788985 1.02440114277342 0.590909090909091 11.3 11 3 increased myocardial infarction size 0.0263308867649317 0.123697980788985 1.02440114277342 0.590909090909091 11.3 11 3 abnormal lysosome physiology 0.0263308867649317 0.123697980788985 1.02440114277342 0.590909090909091 11.3 11 3 abnormal vascular branching morphogenesis 0.0263308867649317 0.123697980788985 1.02440114277342 0.590909090909091 11.3 11 3 parakeratosis 0.0263308867649317 0.123697980788985 1.02440114277342 0.590909090909091 11.3 11 3 abnormal blood-brain barrier function 0.0263308867649317 0.123697980788985 1.02440114277342 0.590909090909091 11.3 11 3 cleft upper lip 0.0263308867649317 0.123697980788985 1.02440114277342 0.590909090909091 11.3 11 3 abnormal temporal bone morphology 0.0263308867649317 0.123697980788985 1.02440114277342 0.590909090909091 11.3 11 3 abnormal sperm midpiece morphology 0.0263308867649317 0.123697980788985 1.02440114277342 0.590909090909091 11.3 11 3 pulmonary vascular congestion 0.0263308867649317 0.123697980788985 1.02440114277342 0.590909090909091 11.3 11 3 increased circulating creatine kinase level 0.0263308867649317 0.123697980788985 1.02440114277342 0.590909090909091 11.3 11 3 abnormal heart ventricle morphology 4.72353133880403e-05 0.000707818325618978 1.02238062769892 0.58974358974359 11.3 11 3 abnormal heart looping 0.00364701446551244 0.0277429617215969 1.02238062769892 0.58974358974359 11.3 11 3 abnormal cranium morphology 1.13008415243031e-07 3.4281516209395e-06 1.0220489013434 0.58955223880597 11.3 11 3 increased inflammatory response 7.59143912603465e-06 0.000143058369894024 1.02191271894482 0.589473684210526 11.3 11 3 abnormal gluconeogenesis 0.00100726617706426 0.00954504615408517 1.01976584348486 0.588235294117647 11.3 11 3 increased kidney weight 0.00100726617706426 0.00954504615408517 1.01976584348486 0.588235294117647 11.3 11 3 abnormal nervous system development 0.0068211800181456 0.0441866804560864 1.01976584348486 0.588235294117647 11.3 11 3 decreased osteoblast cell number 0.0068211800181456 0.0441866804560864 1.01976584348486 0.588235294117647 11.3 11 3 abnormal vagus nerve morphology 0.0516383982518129 0.191574221702289 1.01976584348486 0.588235294117647 11.3 11 3 increased incidence of corneal inflammation 0.0516383982518129 0.191574221702289 1.01976584348486 0.588235294117647 11.3 11 3 hyperlipidemia 0.0516383982518129 0.191574221702289 1.01976584348486 0.588235294117647 11.3 11 3 abnormal survival 0.0516383982518129 0.191574221702289 1.01976584348486 0.588235294117647 11.3 11 3 postnatal lethality, incomplete penetrance 1.98053153978455e-27 8.21095367535677e-25 1.01940677100476 0.588028169014085 11.3 11 3 abnormal glucose homeostasis 8.82411264376087e-10 3.91963932167056e-08 1.01920553258184 0.587912087912088 11.3 11 3 abnormal hair follicle morphology 0.000284359635080777 0.00336030685160776 1.01814716754282 0.587301587301587 11.3 11 3 small testis 5.87713838466467e-14 5.84775269274135e-12 1.01754896121641 0.58695652173913 11.3 11 3 enlarged heart 6.67699314892166e-12 4.20481530580826e-10 1.0162494095418 0.586206896551724 11.3 11 3 abnormal mammary gland development 0.00344133310852572 0.0262184260565321 1.01479137595566 0.585365853658537 11.3 11 3 palatal shelves fail to meet at midline 0.00344133310852572 0.0262184260565321 1.01479137595566 0.585365853658537 11.3 11 3 abnormal pancreatic islet morphology 0.000952783964556027 0.0090947846272699 1.01399358399343 0.584905660377358 11.3 11 3 impaired glucose tolerance 1.80792986640165e-12 1.28492158362118e-10 1.01359790491539 0.584677419354839 11.3 11 3 decreased grip strength 3.61432936379009e-11 1.97596577855557e-09 1.01324679243061 0.584474885844749 11.3 11 3 retinal degeneration 1.17492603830701e-05 0.000211020109768135 1.01126779478915 0.583333333333333 11.3 11 3 abnormal kidney physiology 0.00175305414786304 0.0152472803944382 1.01126779478915 0.583333333333333 11.3 11 3 abnormal adrenal gland morphology 0.0245846089844397 0.117265992039873 1.01126779478915 0.583333333333333 11.3 11 3 abnormal body weight 0.0245846089844397 0.117265992039873 1.01126779478915 0.583333333333333 11.3 11 3 abnormal tumor morphology 0.0245846089844397 0.117265992039873 1.01126779478915 0.583333333333333 11.3 11 3 decreased fatty acid level 0.0245846089844397 0.117265992039873 1.01126779478915 0.583333333333333 11.3 11 3 abnormal inner cell mass apoptosis 0.0245846089844397 0.117265992039873 1.01126779478915 0.583333333333333 11.3 11 3 abnormal adipose tissue distribution 0.104714899340596 0.316498556633939 1.01126779478915 0.583333333333333 11.3 11 3 abnormal glossopharyngeal nerve morphology 0.104714899340596 0.316498556633939 1.01126779478915 0.583333333333333 11.3 11 3 absent optic nerve 0.104714899340596 0.316498556633939 1.01126779478915 0.583333333333333 11.3 11 3 impaired embryo implantation 0.104714899340596 0.316498556633939 1.01126779478915 0.583333333333333 11.3 11 3 abnormal thymus involution 0.104714899340596 0.316498556633939 1.01126779478915 0.583333333333333 11.3 11 3 myocarditis 0.104714899340596 0.316498556633939 1.01126779478915 0.583333333333333 11.3 11 3 abnormal corticospinal tract morphology 0.104714899340596 0.316498556633939 1.01126779478915 0.583333333333333 11.3 11 3 increased urine phosphate level 0.104714899340596 0.316498556633939 1.01126779478915 0.583333333333333 11.3 11 3 abnormal aorta elastic fiber morphology 0.104714899340596 0.316498556633939 1.01126779478915 0.583333333333333 11.3 11 3 loss of dopaminergic neurons 0.104714899340596 0.316498556633939 1.01126779478915 0.583333333333333 11.3 11 3 small intestinal inflammation 0.104714899340596 0.316498556633939 1.01126779478915 0.583333333333333 11.3 11 3 abnormal vascular endothelial cell development 0.104714899340596 0.316498556633939 1.01126779478915 0.583333333333333 11.3 11 3 impaired sperm capacitation 0.104714899340596 0.316498556633939 1.01126779478915 0.583333333333333 11.3 11 3 abnormal defecation 0.104714899340596 0.316498556633939 1.01126779478915 0.583333333333333 11.3 11 3 decreased renal glomerular filtration rate 0.104714899340596 0.316498556633939 1.01126779478915 0.583333333333333 11.3 11 3 reduced cerebellar foliation 0.104714899340596 0.316498556633939 1.01126779478915 0.583333333333333 11.3 11 3 decreased prostaglandin level 0.104714899340596 0.316498556633939 1.01126779478915 0.583333333333333 11.3 11 3 decreased mammary gland epithelial cell proliferation 0.104714899340596 0.316498556633939 1.01126779478915 0.583333333333333 11.3 11 3 increased fibrosarcoma incidence 0.104714899340596 0.316498556633939 1.01126779478915 0.583333333333333 11.3 11 3 increased type II pneumocyte number 0.104714899340596 0.316498556633939 1.01126779478915 0.583333333333333 11.3 11 3 abnormal colon goblet cell morphology 0.104714899340596 0.316498556633939 1.01126779478915 0.583333333333333 11.3 11 3 abnormal seminiferous tubule morphology 8.37172246543133e-08 2.58691424009446e-06 1.00928879714768 0.582191780821918 11.3 11 3 small seminiferous tubules 0.000132551952324788 0.00171757887939475 1.00736328592896 0.581081081081081 11.3 11 3 abnormal retinal photoreceptor layer morphology 0.0120546674442677 0.0675360028549906 1.00660757453666 0.580645161290323 11.3 11 3 preaxial polydactyly 0.0120546674442677 0.0675360028549906 1.00660757453666 0.580645161290323 11.3 11 3 decreased susceptibility to bacterial infection induced morbidity/mortality 0.0120546674442677 0.0675360028549906 1.00660757453666 0.580645161290323 11.3 11 3 hypoglycemia 2.00639445397953e-05 0.000340676191418026 1.00660757453666 0.580645161290323 11.3 11 3 increased circulating chloride level 0.001651474809453 0.0144904535750065 1.00548912167607 0.58 11.3 11 3 testicular atrophy 0.001651474809453 0.0144904535750065 1.00548912167607 0.58 11.3 11 3 increased leukocyte cell number 1.34595468130483e-07 3.91586230379621e-06 1.00429353413543 0.579310344827586 11.3 11 3 abnormal blood vessel morphology 1.34595468130483e-07 3.91586230379621e-06 1.00429353413543 0.579310344827586 11.3 11 3 abnormal facial morphology 0.000847864182203725 0.0082152321294985 1.00366427753509 0.578947368421053 11.3 11 3 decreased total retina thickness 0.00601977157991506 0.0410814315638922 1.00366427753509 0.578947368421053 11.3 11 3 kyphoscoliosis 0.0477715029556248 0.183229627327891 1.00366427753509 0.578947368421053 11.3 11 3 flaky skin 0.0477715029556248 0.183229627327891 1.00366427753509 0.578947368421053 11.3 11 3 delayed sexual maturation 0.0477715029556248 0.183229627327891 1.00366427753509 0.578947368421053 11.3 11 3 abnormal nasal septum morphology 0.0477715029556248 0.183229627327891 1.00366427753509 0.578947368421053 11.3 11 3 abnormal metatarsal bone morphology 0.0477715029556248 0.183229627327891 1.00366427753509 0.578947368421053 11.3 11 3 abnormal digestive system development 0.0477715029556248 0.183229627327891 1.00366427753509 0.578947368421053 11.3 11 3 abnormal sternebra morphology 0.0477715029556248 0.183229627327891 1.00366427753509 0.578947368421053 11.3 11 3 eyelids fail to open 0.0477715029556248 0.183229627327891 1.00366427753509 0.578947368421053 11.3 11 3 decreased circulating magnesium level 0.0477715029556248 0.183229627327891 1.00366427753509 0.578947368421053 11.3 11 3 increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 0.0477715029556248 0.183229627327891 1.00366427753509 0.578947368421053 11.3 11 3 thin interventricular septum 0.0477715029556248 0.183229627327891 1.00366427753509 0.578947368421053 11.3 11 3 decreased lymphocyte cell number 8.14269357876434e-07 2.02549502771763e-05 1.00223861804996 0.578125 11.3 11 3 albuminuria 0.00304384990529585 0.0234051828112007 1.00163667293401 0.577777777777778 11.3 11 3 abnormal xiphoid process morphology 0.0228870450515144 0.10990641808039 1.00015496187938 0.576923076923077 11.3 11 3 respiratory failure 1.14023892365677e-07 3.43799311829845e-06 0.998830253320597 0.576158940397351 11.3 11 3 abnormal heart morphology 6.40497859941081e-11 3.42631919699664e-09 0.998134446804874 0.575757575757576 11.3 11 3 neuron degeneration 0.0028548946750699 0.0221923453257387 0.995898983318189 0.574468085106383 11.3 11 3 increased or absent threshold for auditory brainstem response 3.88328020548918e-13 3.11601919714656e-11 0.995771353049918 0.57439446366782 11.3 11 3 diluted coat color 0.00145841629633714 0.0128418072111102 0.995215925030591 0.574074074074074 11.3 11 3 impaired limb coordination 0.00145841629633714 0.0128418072111102 0.995215925030591 0.574074074074074 11.3 11 3 hydroencephaly 4.41528557561405e-06 9.00247776175406e-05 0.994936762078268 0.573913043478261 11.3 11 3 ventricular septal defect 6.48613906881377e-07 1.66332690037879e-05 0.994271697397734 0.573529411764706 11.3 11 3 reduced male fertility 1.70663034518689e-10 8.66319863449505e-09 0.992811680220939 0.572687224669604 11.3 11 3 domed cranium 0.000364209089571594 0.00411804595595154 0.990629676528145 0.571428571428571 11.3 11 3 short mandible 0.00136765413380192 0.0123238645842684 0.990629676528145 0.571428571428571 11.3 11 3 abnormal long bone hypertrophic chondrocyte zone 0.00267366148881424 0.0208821583297937 0.990629676528145 0.571428571428571 11.3 11 3 decreased urine osmolality 0.00267366148881424 0.0208821583297937 0.990629676528145 0.571428571428571 11.3 11 3 abnormal craniofacial development 0.00267366148881424 0.0208821583297937 0.990629676528145 0.571428571428571 11.3 11 3 abnormal optic nerve morphology 0.00526974336469637 0.0361115333875543 0.990629676528145 0.571428571428571 11.3 11 3 abnormal vibrissa morphology 0.00526974336469637 0.0361115333875543 0.990629676528145 0.571428571428571 11.3 11 3 abnormal dermal layer morphology 0.010501822345162 0.0604705626934966 0.990629676528145 0.571428571428571 11.3 11 3 increased bone resorption 0.0212593359109271 0.102585059318004 0.990629676528145 0.571428571428571 11.3 11 3 prolonged QRS complex duration 0.0212593359109271 0.102585059318004 0.990629676528145 0.571428571428571 11.3 11 3 small ears 0.0440850688483312 0.177589649814128 0.990629676528145 0.571428571428571 11.3 11 3 decreased cochlear outer hair cell number 0.0440850688483312 0.177589649814128 0.990629676528145 0.571428571428571 11.3 11 3 abnormal bile salt homeostasis 0.0440850688483312 0.177589649814128 0.990629676528145 0.571428571428571 11.3 11 3 megacephaly 0.0953409602335192 0.293879353879652 0.990629676528145 0.571428571428571 11.3 11 3 translucent skin 0.0953409602335192 0.293879353879652 0.990629676528145 0.571428571428571 11.3 11 3 abnormal placing response 0.0953409602335192 0.293879353879652 0.990629676528145 0.571428571428571 11.3 11 3 abnormal kidney medulla morphology 0.0953409602335192 0.293879353879652 0.990629676528145 0.571428571428571 11.3 11 3 intestinal obstruction 0.0953409602335192 0.293879353879652 0.990629676528145 0.571428571428571 11.3 11 3 abnormal ventral body wall morphology 0.0953409602335192 0.293879353879652 0.990629676528145 0.571428571428571 11.3 11 3 decreased CNS synapse formation 0.0953409602335192 0.293879353879652 0.990629676528145 0.571428571428571 11.3 11 3 abnormal iris pigmentation 0.0953409602335192 0.293879353879652 0.990629676528145 0.571428571428571 11.3 11 3 decreased tongue size 0.0953409602335192 0.293879353879652 0.990629676528145 0.571428571428571 11.3 11 3 sternebra fusion 0.0953409602335192 0.293879353879652 0.990629676528145 0.571428571428571 11.3 11 3 increased stomach tumor incidence 0.0953409602335192 0.293879353879652 0.990629676528145 0.571428571428571 11.3 11 3 decreased B cell proliferation 0.000177681873802051 0.00224357188366803 0.987494772488499 0.569620253164557 11.3 11 3 decreased litter size 2.7165091965506e-12 1.85131962367661e-10 0.987104304013811 0.569395017793594 11.3 11 3 abnormal spermiogenesis 0.00128101234553711 0.011650889248715 0.986359721025869 0.568965517241379 11.3 11 3 female infertility 1.50787901485017e-11 8.62264149296507e-10 0.984112376024671 0.567669172932331 11.3 11 3 hypoactivity 9.72142900471113e-16 1.16417077695289e-13 0.984060514216951 0.56763925729443 11.3 11 3 abnormal hair follicle development 0.00977707633398432 0.0565592497227581 0.98393623276782 0.567567567567568 11.3 11 3 increased trabecular bone volume 0.00977707633398432 0.0565592497227581 0.98393623276782 0.567567567567568 11.3 11 3 decreased white adipose tissue amount 0.000618418242754447 0.00640964741188203 0.983236917748085 0.567164179104478 11.3 11 3 liver inflammation 5.8257257128673e-06 0.000116397531813313 0.982374429223744 0.566666666666667 11.3 11 3 abnormal eating behavior 0.00119858255163746 0.0111041865817437 0.982374429223744 0.566666666666667 11.3 11 3 impaired coordination 2.02273149464965e-14 2.14108280550681e-12 0.982040401876167 0.566473988439306 11.3 11 3 increased bone mineral density 1.10642176851588e-05 0.000200161756304237 0.981863042222587 0.566371681415929 11.3 11 3 abnormal placenta development 0.00233616625128936 0.0192424289737824 0.981284113542031 0.566037735849057 11.3 11 3 limb grasping 2.96886786656592e-08 1.04752607348691e-06 0.981104391176913 0.565934065934066 11.3 11 3 abnormal neuron morphology 4.00970905923868e-05 0.000613793925221921 0.980623316159174 0.565656565656566 11.3 11 3 failure of embryo implantation 0.0406148808901742 0.164543186016789 0.97986196265284 0.565217391304348 11.3 11 3 abnormal B cell morphology 0.0406148808901742 0.164543186016789 0.97986196265284 0.565217391304348 11.3 11 3 abnormal palatal shelf fusion at midline 0.0406148808901742 0.164543186016789 0.97986196265284 0.565217391304348 11.3 11 3 decreased neutrophil cell number 9.74324866636967e-06 0.000180195769944941 0.977929296059836 0.564102564102564 11.3 11 3 small lens 0.00909039843384789 0.0534813193603255 0.977929296059836 0.564102564102564 11.3 11 3 acanthosis 0.00909039843384789 0.0534813193603255 0.977929296059836 0.564102564102564 11.3 11 3 decreased B-1 B cell number 0.00909039843384789 0.0534813193603255 0.977929296059836 0.564102564102564 11.3 11 3 abnormal ovary morphology 0.000541278252846321 0.00572948788917116 0.976677145872819 0.563380281690141 11.3 11 3 abnormal lung morphology 9.13596923258719e-06 0.000169594951239258 0.97606159304979 0.563025210084034 11.3 11 3 scoliosis 0.0182557151781043 0.088780237547477 0.975151087832393 0.5625 11.3 11 3 polydipsia 0.0182557151781043 0.088780237547477 0.975151087832393 0.5625 11.3 11 3 increased circulating follicle stimulating hormone level 0.0182557151781043 0.088780237547477 0.975151087832393 0.5625 11.3 11 3 abnormal tympanic ring morphology 0.0867489278311043 0.271773246826035 0.975151087832393 0.5625 11.3 11 3 decreased mast cell number 0.0867489278311043 0.271773246826035 0.975151087832393 0.5625 11.3 11 3 delayed hair appearance 0.0867489278311043 0.271773246826035 0.975151087832393 0.5625 11.3 11 3 abnormal pituitary gland morphology 0.0867489278311043 0.271773246826035 0.975151087832393 0.5625 11.3 11 3 abnormal intestinal absorption 0.0867489278311043 0.271773246826035 0.975151087832393 0.5625 11.3 11 3 abnormal olfaction 0.0867489278311043 0.271773246826035 0.975151087832393 0.5625 11.3 11 3 white spotting 0.0867489278311043 0.271773246826035 0.975151087832393 0.5625 11.3 11 3 impaired muscle relaxation 0.0867489278311043 0.271773246826035 0.975151087832393 0.5625 11.3 11 3 abnormal pulmonary elastic fiber morphology 0.0867489278311043 0.271773246826035 0.975151087832393 0.5625 11.3 11 3 decreased aggression towards mice 0.0867489278311043 0.271773246826035 0.975151087832393 0.5625 11.3 11 3 small pancreas 0.0867489278311043 0.271773246826035 0.975151087832393 0.5625 11.3 11 3 bowed tibia 0.0867489278311043 0.271773246826035 0.975151087832393 0.5625 11.3 11 3 increased cochlear outer hair cell number 0.0867489278311043 0.271773246826035 0.975151087832393 0.5625 11.3 11 3 small epididymis 0.0867489278311043 0.271773246826035 0.975151087832393 0.5625 11.3 11 3 abnormal amnion morphology 0.0867489278311043 0.271773246826035 0.975151087832393 0.5625 11.3 11 3 decreased skeletal muscle weight 0.0867489278311043 0.271773246826035 0.975151087832393 0.5625 11.3 11 3 dilated respiratory conducting tubes 0.0867489278311043 0.271773246826035 0.975151087832393 0.5625 11.3 11 3 abnormal pulmonary alveolus wall morphology 0.0867489278311043 0.271773246826035 0.975151087832393 0.5625 11.3 11 3 embryonic lethality between somite formation and embryo turning, incomplete penetrance 0.0867489278311043 0.271773246826035 0.975151087832393 0.5625 11.3 11 3 decreased adipocyte glucose uptake 0.0867489278311043 0.271773246826035 0.975151087832393 0.5625 11.3 11 3 abnormal muscle physiology 0.000128356839222613 0.00168046125034868 0.973933670743963 0.561797752808989 11.3 11 3 neonatal lethality, incomplete penetrance 9.50522828576901e-11 4.9258865335105e-09 0.973484162895927 0.561538461538462 11.3 11 3 absent vitelline blood vessels 0.00203298527184762 0.0172301562648073 0.97325020851888 0.56140350877193 11.3 11 3 increased tumor growth/size 0.00844270750990064 0.0517909616051241 0.972508401957509 0.560975609756098 11.3 11 3 abnormal cholesterol homeostasis 0.00844270750990064 0.0517909616051241 0.972508401957509 0.560975609756098 11.3 11 3 infertility 3.08925439788032e-05 0.000494181370722012 0.972113233976218 0.560747663551402 11.3 11 3 increased monocyte cell number 5.88176129143036e-05 0.000863178832591918 0.970817082997583 0.56 11.3 11 3 decreased double-positive T cell number 5.88176129143036e-05 0.000863178832591918 0.970817082997583 0.56 11.3 11 3 abnormal axon extension 0.00397462635345582 0.0296903395021662 0.970817082997583 0.56 11.3 11 3 abnormal circulating protein level 0.00397462635345582 0.0296903395021662 0.970817082997583 0.56 11.3 11 3 decreased respiratory quotient 0.00397462635345582 0.0296903395021662 0.970817082997583 0.56 11.3 11 3 mandible hypoplasia 0.0373747799138293 0.152284627413023 0.970817082997583 0.56 11.3 11 3 increased cellular sensitivity to ionizing radiation 0.0373747799138293 0.152284627413023 0.970817082997583 0.56 11.3 11 3 abnormal cochlear outer hair cell morphology 0.0373747799138293 0.152284627413023 0.970817082997583 0.56 11.3 11 3 increased liver glycogen level 0.0373747799138293 0.152284627413023 0.970817082997583 0.56 11.3 11 3 abnormal colon morphology 0.00189412943954625 0.0163598853502475 0.969641759652549 0.559322033898305 11.3 11 3 increased hemoglobin content 0.00189412943954625 0.0163598853502475 0.969641759652549 0.559322033898305 11.3 11 3 impaired balance 5.49936990724806e-05 0.000811850602034395 0.968777551310613 0.558823529411765 11.3 11 3 short maxilla 0.0168879194631126 0.0873209883788731 0.968777551310613 0.558823529411765 11.3 11 3 abnormal oocyte morphology 0.0168879194631126 0.0873209883788731 0.968777551310613 0.558823529411765 11.3 11 3 abnormal spleen red pulp morphology 0.0168879194631126 0.0873209883788731 0.968777551310613 0.558823529411765 11.3 11 3 increased susceptibility to weight gain 0.0168879194631126 0.0873209883788731 0.968777551310613 0.558823529411765 11.3 11 3 abnormal male reproductive system morphology 0.00783397913093014 0.0491750062373935 0.967591777074003 0.558139534883721 11.3 11 3 abnormal left-right axis patterning 0.00783397913093014 0.0491750062373935 0.967591777074003 0.558139534883721 11.3 11 3 decreased cardiac muscle contractility 5.13941716319212e-05 0.000767825837443867 0.966816463150065 0.557692307692308 11.3 11 3 decreased kidney weight 0.00369538230773247 0.0279400106093754 0.966816463150065 0.557692307692308 11.3 11 3 abnormal female meiosis 0.00369538230773247 0.0279400106093754 0.966816463150065 0.557692307692308 11.3 11 3 thick epidermis 0.000848769711469795 0.0082152321294985 0.965863934614942 0.557142857142857 11.3 11 3 improved glucose tolerance 4.27605386613436e-08 1.39956368315911e-06 0.964094953049713 0.556122448979592 11.3 11 3 abnormal small intestine morphology 0.0034333536949796 0.0262184260565321 0.963112185513475 0.555555555555556 11.3 11 3 abnormal neuronal precursor proliferation 0.0034333536949796 0.0262184260565321 0.963112185513475 0.555555555555556 11.3 11 3 axon degeneration 0.0034333536949796 0.0262184260565321 0.963112185513475 0.555555555555556 11.3 11 3 irregular heartbeat 0.00726352737161865 0.0467477990605469 0.963112185513475 0.555555555555556 11.3 11 3 decreased osteoclast cell number 0.00726352737161865 0.0467477990605469 0.963112185513475 0.555555555555556 11.3 11 3 lethality at weaning, complete penetrance 0.00726352737161865 0.0467477990605469 0.963112185513475 0.555555555555556 11.3 11 3 rectal prolapse 0.0343659400580651 0.140641105989941 0.963112185513475 0.555555555555556 11.3 11 3 abnormal trigeminal nerve morphology 0.0343659400580651 0.140641105989941 0.963112185513475 0.555555555555556 11.3 11 3 increased brain weight 0.0343659400580651 0.140641105989941 0.963112185513475 0.555555555555556 11.3 11 3 abnormal brain commissure morphology 0.0343659400580651 0.140641105989941 0.963112185513475 0.555555555555556 11.3 11 3 cryptorchism 0.0343659400580651 0.140641105989941 0.963112185513475 0.555555555555556 11.3 11 3 abnormal skin appearance 0.0343659400580651 0.140641105989941 0.963112185513475 0.555555555555556 11.3 11 3 decreased bone ossification 0.0343659400580651 0.140641105989941 0.963112185513475 0.555555555555556 11.3 11 3 abnormal neuromuscular synapse morphology 0.000790593634107588 0.00778698143027895 0.963112185513475 0.555555555555556 11.3 11 3 abnormal pharyngeal arch morphology 0.0156095905896484 0.0842274546458795 0.963112185513475 0.555555555555556 11.3 11 3 abnormal retinal blood vessel morphology 0.0156095905896484 0.0842274546458795 0.963112185513475 0.555555555555556 11.3 11 3 abnormal heart shape 0.078925892406108 0.252512099498641 0.963112185513475 0.555555555555556 11.3 11 3 abnormal stomach glandular epithelium morphology 0.078925892406108 0.252512099498641 0.963112185513475 0.555555555555556 11.3 11 3 cortical renal glomerulopathies 0.078925892406108 0.252512099498641 0.963112185513475 0.555555555555556 11.3 11 3 delayed kidney development 0.078925892406108 0.252512099498641 0.963112185513475 0.555555555555556 11.3 11 3 absent spleen 0.078925892406108 0.252512099498641 0.963112185513475 0.555555555555556 11.3 11 3 eye inflammation 0.078925892406108 0.252512099498641 0.963112185513475 0.555555555555556 11.3 11 3 abnormal thyroid cartilage morphology 0.078925892406108 0.252512099498641 0.963112185513475 0.555555555555556 11.3 11 3 abnormal thymus cortex morphology 0.078925892406108 0.252512099498641 0.963112185513475 0.555555555555556 11.3 11 3 acidosis 0.078925892406108 0.252512099498641 0.963112185513475 0.555555555555556 11.3 11 3 abnormal pregnancy 0.078925892406108 0.252512099498641 0.963112185513475 0.555555555555556 11.3 11 3 heart hyperplasia 0.199480252601512 0.45712310303663 0.963112185513475 0.555555555555556 11.3 11 3 abnormal head movements 0.199480252601512 0.45712310303663 0.963112185513475 0.555555555555556 11.3 11 3 thick tail 0.199480252601512 0.45712310303663 0.963112185513475 0.555555555555556 11.3 11 3 abnormal cholinergic neuron morphology 0.199480252601512 0.45712310303663 0.963112185513475 0.555555555555556 11.3 11 3 abnormal germ cell morphology 0.199480252601512 0.45712310303663 0.963112185513475 0.555555555555556 11.3 11 3 long gestation period 0.199480252601512 0.45712310303663 0.963112185513475 0.555555555555556 11.3 11 3 abnormal thymus lobule morphology 0.199480252601512 0.45712310303663 0.963112185513475 0.555555555555556 11.3 11 3 abnormal gut-associated lymphoid tissue morphology 0.199480252601512 0.45712310303663 0.963112185513475 0.555555555555556 11.3 11 3 yellow coat color 0.199480252601512 0.45712310303663 0.963112185513475 0.555555555555556 11.3 11 3 abnormal abdominal wall morphology 0.199480252601512 0.45712310303663 0.963112185513475 0.555555555555556 11.3 11 3 abnormal ovary physiology 0.199480252601512 0.45712310303663 0.963112185513475 0.555555555555556 11.3 11 3 abnormal thymus physiology 0.199480252601512 0.45712310303663 0.963112185513475 0.555555555555556 11.3 11 3 abnormal stria vascularis vasculature morphology 0.199480252601512 0.45712310303663 0.963112185513475 0.555555555555556 11.3 11 3 abnormal optic chiasm morphology 0.199480252601512 0.45712310303663 0.963112185513475 0.555555555555556 11.3 11 3 multiflagellated sperm 0.199480252601512 0.45712310303663 0.963112185513475 0.555555555555556 11.3 11 3 abnormal hyoid bone lesser horn morphology 0.199480252601512 0.45712310303663 0.963112185513475 0.555555555555556 11.3 11 3 abnormal ventricle myocardium morphology 0.199480252601512 0.45712310303663 0.963112185513475 0.555555555555556 11.3 11 3 prolonged RR interval 0.199480252601512 0.45712310303663 0.963112185513475 0.555555555555556 11.3 11 3 fusion of atlas and occipital bones 0.199480252601512 0.45712310303663 0.963112185513475 0.555555555555556 11.3 11 3 abnormal heart left ventricle pressure 0.199480252601512 0.45712310303663 0.963112185513475 0.555555555555556 11.3 11 3 decreased bone trabecular spacing 0.199480252601512 0.45712310303663 0.963112185513475 0.555555555555556 11.3 11 3 male infertility 3.33238495253782e-18 5.52620504629188e-16 0.961580396749239 0.554671968190855 11.3 11 3 abnormal pulmonary alveolus morphology 8.52242153433186e-05 0.0011648089871786 0.961205032670874 0.554455445544555 11.3 11 3 weight loss 2.83925725734054e-07 7.76115651388418e-06 0.960910786232301 0.554285714285714 11.3 11 3 postnatal lethality 5.71464063615532e-07 1.48074672733712e-05 0.960791433259225 0.55421686746988 11.3 11 3 abnormal neuron differentiation 3.90393312763123e-05 0.000606939603436417 0.959672499136641 0.553571428571429 11.3 11 3 increased bone marrow cell number 0.0144184527948935 0.0792016295406067 0.958043174010772 0.552631578947368 11.3 11 3 decreased neuron apoptosis 0.0144184527948935 0.0792016295406067 0.958043174010772 0.552631578947368 11.3 11 3 abnormal retinal outer nuclear layer morphology 0.0144184527948935 0.0792016295406067 0.958043174010772 0.552631578947368 11.3 11 3 maternal effect 0.00141821353190113 0.0126899502180002 0.957362262017872 0.552238805970149 11.3 11 3 focal hair loss 0.0315822649502185 0.135198032048925 0.956470032509934 0.551724137931034 11.3 11 3 stomach inflammation 0.0315822649502185 0.135198032048925 0.956470032509934 0.551724137931034 11.3 11 3 short sternum 0.0315822649502185 0.135198032048925 0.956470032509934 0.551724137931034 11.3 11 3 lung inflammation 7.70867141562297e-06 0.000144719397331035 0.956030478267052 0.551470588235294 11.3 11 3 increased urine protein level 0.000637024226398097 0.00656148142097419 0.955703630240294 0.551282051282051 11.3 11 3 absent gastric milk in neonates 0.000637024226398097 0.00656148142097419 0.955703630240294 0.551282051282051 11.3 11 3 cardiac hypertrophy 0.000140825358890444 0.00179642605251271 0.955250045223569 0.551020408163265 11.3 11 3 neonatal lethality, complete penetrance 5.51348128606273e-16 6.85739234954052e-14 0.954241415383746 0.550438596491228 11.3 11 3 abnormal skin pigmentation 0.0133111472963088 0.0738271547370525 0.95348106365834 0.55 11.3 11 3 increased susceptibility to weight loss 0.0133111472963088 0.0738271547370525 0.95348106365834 0.55 11.3 11 3 abnormal cell proliferation 0.0718255564532533 0.232033859321386 0.95348106365834 0.55 11.3 11 3 abnormal vascular regression 0.0718255564532533 0.232033859321386 0.95348106365834 0.55 11.3 11 3 abnormal fibula morphology 0.0718255564532533 0.232033859321386 0.95348106365834 0.55 11.3 11 3 abnormal Peyer's patch T cell area morphology 0.0718255564532533 0.232033859321386 0.95348106365834 0.55 11.3 11 3 abnormal hyoid bone morphology 0.0718255564532533 0.232033859321386 0.95348106365834 0.55 11.3 11 3 abnormal heart right ventricle morphology 0.0718255564532533 0.232033859321386 0.95348106365834 0.55 11.3 11 3 abnormal incus morphology 0.0718255564532533 0.232033859321386 0.95348106365834 0.55 11.3 11 3 decreased circulating VLDL cholesterol level 0.0718255564532533 0.232033859321386 0.95348106365834 0.55 11.3 11 3 abnormal heart electrocardiography waveform feature 0.0718255564532533 0.232033859321386 0.95348106365834 0.55 11.3 11 3 ataxia 7.62349709805866e-08 2.38533950080766e-06 0.95262284487917 0.54950495049505 11.3 11 3 postnatal lethality, complete penetrance 1.33250196145827e-13 1.14296504452671e-11 0.952133704642337 0.549222797927461 11.3 11 3 increased lung adenocarcinoma incidence 0.00576902149496986 0.0394785171079437 0.951781453919199 0.549019607843137 11.3 11 3 sparse hair 0.000550459866977809 0.00581430538899066 0.951366914958432 0.548780487804878 11.3 11 3 abnormal cranial ganglia morphology 0.0290136048156001 0.131579474892991 0.950684931506849 0.548387096774194 11.3 11 3 abnormal object recognition memory 0.0290136048156001 0.131579474892991 0.950684931506849 0.548387096774194 11.3 11 3 cachexia 0.000113538172291819 0.00151842044933279 0.950147213785409 0.548076923076923 11.3 11 3 abnormal cartilage morphology 0.0122836641067268 0.0684336270223584 0.949353440006139 0.547619047619048 11.3 11 3 skin edema 0.0122836641067268 0.0684336270223584 0.949353440006139 0.547619047619048 11.3 11 3 cyanosis 2.3226396508561e-07 6.49164733876915e-06 0.948063557614827 0.546875 11.3 11 3 abnormal neurocranium morphology 0.00105397579850901 0.00996868744787518 0.947702390545259 0.546666666666667 11.3 11 3 abnormal joint morphology 0.00493703499513288 0.0340202648499215 0.945601054867775 0.545454545454545 11.3 11 3 increased T cell number 0.000441069194362012 0.00476352984922531 0.945601054867775 0.545454545454545 11.3 11 3 abnormal skin morphology 0.00218506419096842 0.0183626593751147 0.945601054867775 0.545454545454545 11.3 11 3 abnormal gametogenesis 0.0113316395529858 0.0646945807988785 0.945601054867775 0.545454545454545 11.3 11 3 abnormal T cell subpopulation ratio 0.0266477070756604 0.124832714408108 0.945601054867775 0.545454545454545 11.3 11 3 abnormal middle ear ossicle morphology 0.0266477070756604 0.124832714408108 0.945601054867775 0.545454545454545 11.3 11 3 decreased sensitivity to xenobiotic induced morbidity/mortality 0.0266477070756604 0.124832714408108 0.945601054867775 0.545454545454545 11.3 11 3 abnormal chorion morphology 0.0653900873484109 0.218295389972812 0.945601054867775 0.545454545454545 11.3 11 3 abnormal tracheal cartilage morphology 0.0653900873484109 0.218295389972812 0.945601054867775 0.545454545454545 11.3 11 3 abnormal retinal outer plexiform layer morphology 0.0653900873484109 0.218295389972812 0.945601054867775 0.545454545454545 11.3 11 3 abnormal ear position 0.176748012875767 0.412246302886518 0.945601054867775 0.545454545454545 11.3 11 3 abnormal sphenoid bone morphology 0.176748012875767 0.412246302886518 0.945601054867775 0.545454545454545 11.3 11 3 abnormal awl hair morphology 0.176748012875767 0.412246302886518 0.945601054867775 0.545454545454545 11.3 11 3 enlarged cranium 0.176748012875767 0.412246302886518 0.945601054867775 0.545454545454545 11.3 11 3 abnormal large intestine morphology 0.176748012875767 0.412246302886518 0.945601054867775 0.545454545454545 11.3 11 3 impaired myelopoiesis 0.176748012875767 0.412246302886518 0.945601054867775 0.545454545454545 11.3 11 3 abnormal fear/anxiety-related behavior 0.176748012875767 0.412246302886518 0.945601054867775 0.545454545454545 11.3 11 3 abnormal larynx morphology 0.176748012875767 0.412246302886518 0.945601054867775 0.545454545454545 11.3 11 3 allodynia 0.176748012875767 0.412246302886518 0.945601054867775 0.545454545454545 11.3 11 3 abnormal frequency of paradoxical sleep 0.176748012875767 0.412246302886518 0.945601054867775 0.545454545454545 11.3 11 3 dilated renal glomerular capsule 0.176748012875767 0.412246302886518 0.945601054867775 0.545454545454545 11.3 11 3 pathological neovascularization 0.176748012875767 0.412246302886518 0.945601054867775 0.545454545454545 11.3 11 3 abnormal pituitary gland development 0.176748012875767 0.412246302886518 0.945601054867775 0.545454545454545 11.3 11 3 abnormal spinal cord ventral horn morphology 0.176748012875767 0.412246302886518 0.945601054867775 0.545454545454545 11.3 11 3 cyclopia 0.176748012875767 0.412246302886518 0.945601054867775 0.545454545454545 11.3 11 3 chylous ascites 0.176748012875767 0.412246302886518 0.945601054867775 0.545454545454545 11.3 11 3 decreased colon length 0.176748012875767 0.412246302886518 0.945601054867775 0.545454545454545 11.3 11 3 abnormal locomotor behavior 0.000379987123915578 0.00427700439248869 0.942174964089269 0.543478260869565 11.3 11 3 respiratory distress 1.41527313940917e-06 3.33695917941262e-05 0.941957120166936 0.543352601156069 11.3 11 3 abnormal midbrain development 0.0244714097906789 0.117265992039873 0.941098192701738 0.542857142857143 11.3 11 3 abnormal lipid level 0.000779372457657678 0.00778222259183772 0.939904662970981 0.542168674698795 11.3 11 3 curly vibrissae 0.0595597476878605 0.215341384263885 0.939034380875638 0.541666666666667 11.3 11 3 abnormal vasodilation 0.0595597476878605 0.215341384263885 0.939034380875638 0.541666666666667 11.3 11 3 small lymph nodes 0.0595597476878605 0.215341384263885 0.939034380875638 0.541666666666667 11.3 11 3 hypopigmentation 0.0595597476878605 0.215341384263885 0.939034380875638 0.541666666666667 11.3 11 3 increased circulating total protein level 0.0595597476878605 0.215341384263885 0.939034380875638 0.541666666666667 11.3 11 3 abnormal cardiovascular system physiology 2.69521306107291e-05 0.00043676498302403 0.938491272500348 0.541353383458647 11.3 11 3 increased osteoclast cell number 0.0039001078922538 0.0293097232084028 0.937850226549187 0.540983606557377 11.3 11 3 abnormal branching of the mammary ductal tree 0.0224713720669003 0.108119029045289 0.937082126445543 0.540540540540541 11.3 11 3 decreased circulating chloride level 0.0224713720669003 0.108119029045289 0.937082126445543 0.540540540540541 11.3 11 3 decreased T cell number 4.5966189707263e-06 9.33395076708709e-05 0.936791107151616 0.540372670807453 11.3 11 3 increased body length 0.00888323824263013 0.0534813193603255 0.936145044319098 0.54 11.3 11 3 abnormal nervous system physiology 0.000110391462571962 0.00148431763863652 0.934637564376555 0.539130434782609 11.3 11 3 small ovary 0.000574326505537708 0.00605354738358072 0.933477964420752 0.538461538461538 11.3 11 3 abnormal snout morphology 0.00818826721341345 0.0506674494859849 0.933477964420752 0.538461538461538 11.3 11 3 abnormal skin condition 0.00818826721341345 0.0506674494859849 0.933477964420752 0.538461538461538 11.3 11 3 increased susceptibility to injury 0.00818826721341345 0.0506674494859849 0.933477964420752 0.538461538461538 11.3 11 3 abnormal lens fiber morphology 0.0206345162161134 0.099763574514251 0.933477964420752 0.538461538461538 11.3 11 3 increased vascular permeability 0.0206345162161134 0.099763574514251 0.933477964420752 0.538461538461538 11.3 11 3 short hair 0.157410036182438 0.372911871432204 0.933477964420752 0.538461538461538 11.3 11 3 excessive scratching 0.157410036182438 0.372911871432204 0.933477964420752 0.538461538461538 11.3 11 3 lymphoid hypoplasia 0.157410036182438 0.372911871432204 0.933477964420752 0.538461538461538 11.3 11 3 dystrophic cardiac calcinosis 0.157410036182438 0.372911871432204 0.933477964420752 0.538461538461538 11.3 11 3 abnormal soleus morphology 0.157410036182438 0.372911871432204 0.933477964420752 0.538461538461538 11.3 11 3 abnormal GABAergic neuron morphology 0.157410036182438 0.372911871432204 0.933477964420752 0.538461538461538 11.3 11 3 orthokeratosis 0.157410036182438 0.372911871432204 0.933477964420752 0.538461538461538 11.3 11 3 empty decidua capsularis 0.157410036182438 0.372911871432204 0.933477964420752 0.538461538461538 11.3 11 3 abnormal aorta tunica media morphology 0.157410036182438 0.372911871432204 0.933477964420752 0.538461538461538 11.3 11 3 decreased cardiac stroke volume 0.157410036182438 0.372911871432204 0.933477964420752 0.538461538461538 11.3 11 3 increased circulating triglyceride level 1.72752760775888e-05 0.000299458182878064 0.932558281697185 0.537931034482759 11.3 11 3 increased cell proliferation 0.00754688940584231 0.0485087529639089 0.931008445996359 0.537037037037037 11.3 11 3 scaly skin 0.0189482881016234 0.0919685202981235 0.930225427959356 0.536585365853659 11.3 11 3 short humerus 0.0189482881016234 0.0919685202981235 0.930225427959356 0.536585365853659 11.3 11 3 abnormal epidermal layer morphology 0.00284073002775318 0.0221167948170142 0.929612631234745 0.536231884057971 11.3 11 3 abnormal coat appearance 0.00284073002775318 0.0221167948170142 0.929612631234745 0.536231884057971 11.3 11 3 increased food intake 0.00108853962946764 0.0101986528372909 0.928715321745136 0.535714285714286 11.3 11 3 abnormal circulating cholesterol level 0.0494889448432242 0.184563343774393 0.928715321745136 0.535714285714286 11.3 11 3 shortened head 0.0494889448432242 0.184563343774393 0.928715321745136 0.535714285714286 11.3 11 3 abnormal ovulation 0.0494889448432242 0.184563343774393 0.928715321745136 0.535714285714286 11.3 11 3 straub tail 0.0494889448432242 0.184563343774393 0.928715321745136 0.535714285714286 11.3 11 3 abnormal retinal inner nuclear layer morphology 0.0494889448432242 0.184563343774393 0.928715321745136 0.535714285714286 11.3 11 3 abnormal skeletal muscle fiber morphology 0.00262352124982538 0.0208821583297937 0.927843288579178 0.535211267605634 11.3 11 3 decreased oxygen consumption 0.0174008018288931 0.0873209883788731 0.927275453029253 0.534883720930233 11.3 11 3 abnormal enzyme/coenzyme level 0.00640955825410211 0.0428203811863781 0.926580343993998 0.53448275862069 11.3 11 3 increased liver weight 0.000930887188653399 0.00890608416067435 0.925901032891363 0.534090909090909 11.3 11 3 abnormal eye physiology 0.00590648437152876 0.0403636809730159 0.924587698092936 0.533333333333333 11.3 11 3 emphysema 0.045146519309143 0.181424825172041 0.924587698092936 0.533333333333333 11.3 11 3 disorganized myocardium 0.045146519309143 0.181424825172041 0.924587698092936 0.533333333333333 11.3 11 3 abnormal microglial cell physiology 0.045146519309143 0.181424825172041 0.924587698092936 0.533333333333333 11.3 11 3 no suckling reflex 0.140746017679372 0.339666734471754 0.924587698092936 0.533333333333333 11.3 11 3 audiogenic seizures 0.140746017679372 0.339666734471754 0.924587698092936 0.533333333333333 11.3 11 3 abnormal seizure response to electrical stimulation 0.140746017679372 0.339666734471754 0.924587698092936 0.533333333333333 11.3 11 3 arthritis 0.140746017679372 0.339666734471754 0.924587698092936 0.533333333333333 11.3 11 3 abnormal pericyte morphology 0.140746017679372 0.339666734471754 0.924587698092936 0.533333333333333 11.3 11 3 abnormal zygomatic bone morphology 0.140746017679372 0.339666734471754 0.924587698092936 0.533333333333333 11.3 11 3 abnormal cerebral aqueduct morphology 0.140746017679372 0.339666734471754 0.924587698092936 0.533333333333333 11.3 11 3 abnormal Muller cell morphology 0.140746017679372 0.339666734471754 0.924587698092936 0.533333333333333 11.3 11 3 liver vascular congestion 0.140746017679372 0.339666734471754 0.924587698092936 0.533333333333333 11.3 11 3 abnormal autopod morphology 0.0159809106174053 0.0861376276506947 0.924587698092936 0.533333333333333 11.3 11 3 neonatal lethality 0.0412058797380957 0.166551805976071 0.92097602739726 0.53125 11.3 11 3 hyperactivity 5.4389616682339e-11 2.94117764124605e-09 0.920537954132286 0.53099730458221 11.3 11 3 decreased heart rate 0.000581081429527617 0.00608606339347346 0.918809024979855 0.53 11.3 11 3 distended abdomen 0.012386732083748 0.068930639951506 0.91778925913637 0.529411764705882 11.3 11 3 overexpanded pulmonary alveoli 0.0376274681397767 0.153188751223722 0.91778925913637 0.529411764705882 11.3 11 3 abnormal adipose tissue morphology 0.126248273607807 0.339666734471754 0.91778925913637 0.529411764705882 11.3 11 3 abnormal bone marrow cavity morphology 0.126248273607807 0.339666734471754 0.91778925913637 0.529411764705882 11.3 11 3 hydroureter 0.126248273607807 0.339666734471754 0.91778925913637 0.529411764705882 11.3 11 3 distended urinary bladder 0.126248273607807 0.339666734471754 0.91778925913637 0.529411764705882 11.3 11 3 abnormal heart rate 0.126248273607807 0.339666734471754 0.91778925913637 0.529411764705882 11.3 11 3 abnormal cranial suture morphology 0.126248273607807 0.339666734471754 0.91778925913637 0.529411764705882 11.3 11 3 decreased vasoconstriction 0.126248273607807 0.339666734471754 0.91778925913637 0.529411764705882 11.3 11 3 increased regulatory T cell number 0.126248273607807 0.339666734471754 0.91778925913637 0.529411764705882 11.3 11 3 increased circulating magnesium level 0.126248273607807 0.339666734471754 0.91778925913637 0.529411764705882 11.3 11 3 abnormal circulating chemokine level 0.126248273607807 0.339666734471754 0.91778925913637 0.529411764705882 11.3 11 3 common atrium 0.126248273607807 0.339666734471754 0.91778925913637 0.529411764705882 11.3 11 3 increased trabecular bone mass 0.126248273607807 0.339666734471754 0.91778925913637 0.529411764705882 11.3 11 3 abnormal electroretinogram waveform feature 0.126248273607807 0.339666734471754 0.91778925913637 0.529411764705882 11.3 11 3 delayed heart development 0.126248273607807 0.339666734471754 0.91778925913637 0.529411764705882 11.3 11 3 decreased body fat mass 0.126248273607807 0.339666734471754 0.91778925913637 0.529411764705882 11.3 11 3 dehydration 0.00392438444088879 0.0294476811363827 0.916332450788535 0.528571428571429 11.3 11 3 no abnormal phenotype detected 1.12543402623769e-45 9.33172380088755e-43 0.916261079774376 0.528530259365994 11.3 11 3 renal hypoplasia 0.0343757959565364 0.140641105989941 0.914956576237801 0.527777777777778 11.3 11 3 short radius 0.0343757959565364 0.140641105989941 0.914956576237801 0.527777777777778 11.3 11 3 abnormal locomotor activation 0.00118042082049135 0.0109563313095978 0.914427393718288 0.527472527472527 11.3 11 3 abnormal contextual conditioning behavior 0.0104578808639414 0.0602873201600327 0.914081019705516 0.527272727272727 11.3 11 3 seizures 0.000334609141456201 0.00382685167527494 0.91242207048645 0.526315789473684 11.3 11 3 short vibrissae 0.113541880684423 0.338343220318087 0.91242207048645 0.526315789473684 11.3 11 3 abnormal stationary movement 0.113541880684423 0.338343220318087 0.91242207048645 0.526315789473684 11.3 11 3 increased malignant tumor incidence 0.113541880684423 0.338343220318087 0.91242207048645 0.526315789473684 11.3 11 3 abnormal neurotransmitter level 0.113541880684423 0.338343220318087 0.91242207048645 0.526315789473684 11.3 11 3 increased susceptibility to ischemic brain injury 0.113541880684423 0.338343220318087 0.91242207048645 0.526315789473684 11.3 11 3 oliguria 0.113541880684423 0.338343220318087 0.91242207048645 0.526315789473684 11.3 11 3 abnormal photoreceptor inner segment morphology 0.113541880684423 0.338343220318087 0.91242207048645 0.526315789473684 11.3 11 3 increased circulating VLDL cholesterol level 0.113541880684423 0.338343220318087 0.91242207048645 0.526315789473684 11.3 11 3 Leydig cell hypoplasia 0.113541880684423 0.338343220318087 0.91242207048645 0.526315789473684 11.3 11 3 shortened RR interval 0.113541880684423 0.338343220318087 0.91242207048645 0.526315789473684 11.3 11 3 right-sided stomach 0.113541880684423 0.338343220318087 0.91242207048645 0.526315789473684 11.3 11 3 abnormal male meiosis 0.00812041703831485 0.0504357987086347 0.909430522714363 0.524590163934426 11.3 11 3 abnormal response/metabolism to endogenous compounds 0.00240428887388792 0.0195127849063498 0.90908394096028 0.524390243902439 11.3 11 3 decreased B cell number 2.39973303702201e-06 5.2133938249714e-05 0.908878683804949 0.524271844660194 11.3 11 3 decreased exploration in new environment 0.00221603975325052 0.0185915645403395 0.908077203484133 0.523809523809524 11.3 11 3 abnormal spleen white pulp morphology 0.0262793744960097 0.123697980788985 0.908077203484133 0.523809523809524 11.3 11 3 abnormal associative learning 0.102340092818667 0.313704227832946 0.908077203484133 0.523809523809524 11.3 11 3 increased keratinocyte proliferation 0.102340092818667 0.313704227832946 0.908077203484133 0.523809523809524 11.3 11 3 complete atrioventricular septal defect 0.102340092818667 0.313704227832946 0.908077203484133 0.523809523809524 11.3 11 3 increased bone ossification 0.102340092818667 0.313704227832946 0.908077203484133 0.523809523809524 11.3 11 3 increased circulating cholesterol level 1.49853681008432e-05 0.000260672050005925 0.906201010914951 0.522727272727273 11.3 11 3 insulin resistance 0.000164328904939783 0.00208555179100872 0.906201010914951 0.522727272727273 11.3 11 3 hyperglycemia 0.00188284352925186 0.0163190706585854 0.906201010914951 0.522727272727273 11.3 11 3 lethality, incomplete penetrance 0.0240479795596487 0.115370008012779 0.906201010914951 0.522727272727273 11.3 11 3 rib fusion 0.00631247707213087 0.0428203811863781 0.905612950557447 0.522388059701492 11.3 11 3 increased sensitivity to induced morbidity/mortality 1.09701678244263e-05 0.000199914230500077 0.904487965525698 0.521739130434783 11.3 11 3 abnormal inner ear morphology 0.0220140194008574 0.106123785386885 0.904487965525698 0.521739130434783 11.3 11 3 abnormal blood vessel physiology 0.0924175853028509 0.287002176580327 0.904487965525698 0.521739130434783 11.3 11 3 abnormal carpal bone morphology 0.0924175853028509 0.287002176580327 0.904487965525698 0.521739130434783 11.3 11 3 blistering 0.0924175853028509 0.287002176580327 0.904487965525698 0.521739130434783 11.3 11 3 abnormal postnatal growth 0.0924175853028509 0.287002176580327 0.904487965525698 0.521739130434783 11.3 11 3 abnormal nasal cavity morphology 0.0924175853028509 0.287002176580327 0.904487965525698 0.521739130434783 11.3 11 3 abnormal cardiovascular development 0.0924175853028509 0.287002176580327 0.904487965525698 0.521739130434783 11.3 11 3 abnormal cardiovascular system morphology 0.0201590182330751 0.097654445676289 0.902917673918883 0.520833333333333 11.3 11 3 obese 0.0041584865251252 0.0306950600333796 0.900572433207405 0.519480519480519 11.3 11 3 abnormal hair growth 0.0169210741437094 0.0873209883788731 0.90013946569144 0.519230769230769 11.3 11 3 abnormal brain wave pattern 0.0169210741437094 0.0873209883788731 0.90013946569144 0.519230769230769 11.3 11 3 wrinkled skin 0.0757199650018003 0.243982533040378 0.898904706479243 0.518518518518518 11.3 11 3 increased body weight 2.29986326890531e-06 5.04748360393878e-05 0.897758144353632 0.517857142857143 11.3 11 3 aphagia 0.0686746733000161 0.223660344829092 0.896690655478063 0.517241379310345 11.3 11 3 increased retinal apoptosis 0.0686746733000161 0.223660344829092 0.896690655478063 0.517241379310345 11.3 11 3 increased lung adenoma incidence 0.0623549614355885 0.218295389972812 0.894762288477035 0.516129032258065 11.3 11 3 decreased thymus weight 0.0623549614355885 0.218295389972812 0.894762288477035 0.516129032258065 11.3 11 3 abnormal CD8-positive, alpha beta T cell morphology 0.0623549614355885 0.218295389972812 0.894762288477035 0.516129032258065 11.3 11 3 decreased double-negative T cell number 0.0623549614355885 0.218295389972812 0.894762288477035 0.516129032258065 11.3 11 3 abnormal vascular development 0.00924751555928944 0.0536205010576515 0.893067662930677 0.515151515151515 11.3 11 3 abnormal tooth development 0.056673938191933 0.207165938651629 0.893067662930677 0.515151515151515 11.3 11 3 abnormal ovarian folliculogenesis 0.056673938191933 0.207165938651629 0.893067662930677 0.515151515151515 11.3 11 3 decreased systemic arterial blood pressure 0.056673938191933 0.207165938651629 0.893067662930677 0.515151515151515 11.3 11 3 dilated heart atrium 0.056673938191933 0.207165938651629 0.893067662930677 0.515151515151515 11.3 11 3 abnormal gait 6.03603160649582e-08 1.94843793007925e-06 0.89204759706782 0.514563106796116 11.3 11 3 increased circulating HDL cholesterol level 0.00130992620336483 0.0118921220104745 0.891566708875331 0.514285714285714 11.3 11 3 abnormal artery morphology 0.0515574122741155 0.191574221702289 0.891566708875331 0.514285714285714 11.3 11 3 abnormal intestinal goblet cell morphology 0.0515574122741155 0.191574221702289 0.891566708875331 0.514285714285714 11.3 11 3 abnormal breathing pattern 0.0469415767289304 0.183229627327891 0.890228020123266 0.513513513513513 11.3 11 3 decreased startle reflex 0.000802360178122261 0.00779637087140283 0.889026632781669 0.512820512820513 11.3 11 3 increased B cell number 0.000802360178122261 0.00779637087140283 0.889026632781669 0.512820512820513 11.3 11 3 abnormal posture 0.00510730440027438 0.0351436229479461 0.88847099113618 0.5125 11.3 11 3 cardiomyopathy 0.0324817334538122 0.137877691381777 0.886063210672397 0.511111111111111 11.3 11 3 increased macrophage cell number 0.0189936485476322 0.0920988318951952 0.882008001470235 0.508771929824561 11.3 11 3 syndactyly 0.0173934504400243 0.0873209883788731 0.881492508775045 0.508474576271186 11.3 11 3 skin lesions 0.0146008070488554 0.0792016295406067 0.880559712469463 0.507936507936508 11.3 11 3 abnormal femur morphology 0.0122714946066649 0.0684336270223584 0.879738294827234 0.507462686567164 11.3 11 3 decreased spleen weight 0.0112548309754379 0.0645822192650559 0.879363299816651 0.507246376811594 11.3 11 3 abnormal dendritic cell physiology 0.00226075875125389 0.0188672273401631 0.874901910578596 0.504672897196262 11.3 11 3 increased anxiety-related response 0.000606181857035146 0.00633561919905431 0.873036945141711 0.503597122302158 11.3 11 3 abnormal phalanx morphology 0.0391784926713554 0.159372854488956 0.866800966962127 0.5 11.3 11 3 abnormal frontal bone morphology 0.0624640933109529 0.218295389972812 0.866800966962127 0.5 11.3 11 3 abnormal reproductive system physiology 0.0624640933109529 0.218295389972812 0.866800966962127 0.5 11.3 11 3 increased metastatic potential 0.0922028272908891 0.287002176580327 0.866800966962127 0.5 11.3 11 3 abnormal response to new environment 0.0922028272908891 0.287002176580327 0.866800966962127 0.5 11.3 11 3 salivary gland inflammation 0.0922028272908891 0.287002176580327 0.866800966962127 0.5 11.3 11 3 rib bifurcation 0.101950985160376 0.313283601712706 0.866800966962127 0.5 11.3 11 3 abnormal respiration 0.101950985160376 0.313283601712706 0.866800966962127 0.5 11.3 11 3 abnormal spleen germinal center morphology 0.101950985160376 0.313283601712706 0.866800966962127 0.5 11.3 11 3 abnormal leukocyte cell number 0.112909788299592 0.338343220318087 0.866800966962127 0.5 11.3 11 3 abnormal stomach morphology 0.112909788299592 0.338343220318087 0.866800966962127 0.5 11.3 11 3 increased susceptibility to otitis media 0.112909788299592 0.338343220318087 0.866800966962127 0.5 11.3 11 3 decreased Peyer's patch number 0.112909788299592 0.338343220318087 0.866800966962127 0.5 11.3 11 3 abnormal malleus morphology 0.125275422917841 0.339666734471754 0.866800966962127 0.5 11.3 11 3 abnormal sensory capabilities/reflexes/nociception 0.125275422917841 0.339666734471754 0.866800966962127 0.5 11.3 11 3 prolonged QT interval 0.125275422917841 0.339666734471754 0.866800966962127 0.5 11.3 11 3 abnormal interparietal bone morphology 0.219479112131356 0.496096584667648 0.866800966962127 0.5 11.3 11 3 abnormal vasoconstriction 0.219479112131356 0.496096584667648 0.866800966962127 0.5 11.3 11 3 increased aggression towards males 0.219479112131356 0.496096584667648 0.866800966962127 0.5 11.3 11 3 abnormal pinna reflex 0.219479112131356 0.496096584667648 0.866800966962127 0.5 11.3 11 3 abnormal antigen presentation 0.219479112131356 0.496096584667648 0.866800966962127 0.5 11.3 11 3 absent otoliths 0.219479112131356 0.496096584667648 0.866800966962127 0.5 11.3 11 3 abnormal voluntary movement 0.219479112131356 0.496096584667648 0.866800966962127 0.5 11.3 11 3 abnormal vascular endothelial cell migration 0.219479112131356 0.496096584667648 0.866800966962127 0.5 11.3 11 3 abnormal uterus development 0.219479112131356 0.496096584667648 0.866800966962127 0.5 11.3 11 3 abnormal hair cuticle 0.219479112131356 0.496096584667648 0.866800966962127 0.5 11.3 11 3 vascular smooth muscle hypoplasia 0.219479112131356 0.496096584667648 0.866800966962127 0.5 11.3 11 3 abnormal pancreas development 0.219479112131356 0.496096584667648 0.866800966962127 0.5 11.3 11 3 premature hair loss 0.219479112131356 0.496096584667648 0.866800966962127 0.5 11.3 11 3 increased circulating growth hormone level 0.219479112131356 0.496096584667648 0.866800966962127 0.5 11.3 11 3 decreased cornea thickness 0.219479112131356 0.496096584667648 0.866800966962127 0.5 11.3 11 3 abnormal esophagus morphology 0.248781126410939 0.542606796972566 0.866800966962127 0.5 11.3 11 3 increased papilloma incidence 0.248781126410939 0.542606796972566 0.866800966962127 0.5 11.3 11 3 altered tumor susceptibility 0.248781126410939 0.542606796972566 0.866800966962127 0.5 11.3 11 3 increased growth rate 0.248781126410939 0.542606796972566 0.866800966962127 0.5 11.3 11 3 increased circulating parathyroid hormone level 0.248781126410939 0.542606796972566 0.866800966962127 0.5 11.3 11 3 decreased synaptic depression 0.248781126410939 0.542606796972566 0.866800966962127 0.5 11.3 11 3 abnormal alisphenoid bone morphology 0.248781126410939 0.542606796972566 0.866800966962127 0.5 11.3 11 3 increased fear-related response 0.248781126410939 0.542606796972566 0.866800966962127 0.5 11.3 11 3 abnormal nucleotide metabolism 0.248781126410939 0.542606796972566 0.866800966962127 0.5 11.3 11 3 small parietal bone 0.248781126410939 0.542606796972566 0.866800966962127 0.5 11.3 11 3 abnormal cochlear outer hair cell physiology 0.248781126410939 0.542606796972566 0.866800966962127 0.5 11.3 11 3 abnormal B cell proliferation 0.248781126410939 0.542606796972566 0.866800966962127 0.5 11.3 11 3 decreased keratinocyte proliferation 0.248781126410939 0.542606796972566 0.866800966962127 0.5 11.3 11 3 abnormal aorta elastic tissue morphology 0.248781126410939 0.542606796972566 0.866800966962127 0.5 11.3 11 3 increased skeletal muscle glycogen level 0.248781126410939 0.542606796972566 0.866800966962127 0.5 11.3 11 3 persistent right dorsal aorta 0.248781126410939 0.542606796972566 0.866800966962127 0.5 11.3 11 3 abnormal respiratory motile cilium morphology 0.248781126410939 0.542606796972566 0.866800966962127 0.5 11.3 11 3 teratozoospermia 0.00679153573465865 0.0441095173367191 0.866800966962127 0.5 11.3 11 3 abnormal inflammatory response 0.0134879750565232 0.0747245834144799 0.866800966962127 0.5 11.3 11 3 cochlear ganglion degeneration 0.0249462308314906 0.118763156350876 0.866800966962127 0.5 11.3 11 3 abnormal digestive system physiology 0.035759767781452 0.146183109870767 0.866800966962127 0.5 11.3 11 3 hypertension 0.0471134931158533 0.183229627327891 0.866800966962127 0.5 11.3 11 3 abnormal pancreatic beta cell morphology 0.0568136572311693 0.207524188491239 0.866800966962127 0.5 11.3 11 3 abnormal epidermis stratum granulosum morphology 0.0687390285916948 0.223660344829092 0.866800966962127 0.5 11.3 11 3 impaired wound healing 0.0687390285916948 0.223660344829092 0.866800966962127 0.5 11.3 11 3 abnormal bone remodeling 0.0757204082440893 0.243982533040378 0.866800966962127 0.5 11.3 11 3 abnormal heart atrium morphology 0.0835040431330815 0.265961981169706 0.866800966962127 0.5 11.3 11 3 abnormal depression-related behavior 0.0835040431330815 0.265961981169706 0.866800966962127 0.5 11.3 11 3 intestinal ulcer 0.139290098288924 0.339666734471754 0.866800966962127 0.5 11.3 11 3 increased skin papilloma incidence 0.139290098288924 0.339666734471754 0.866800966962127 0.5 11.3 11 3 increased coping response 0.139290098288924 0.339666734471754 0.866800966962127 0.5 11.3 11 3 abnormal retinal layer morphology 0.139290098288924 0.339666734471754 0.866800966962127 0.5 11.3 11 3 failure of palatal shelf elevation 0.139290098288924 0.339666734471754 0.866800966962127 0.5 11.3 11 3 waved hair 0.155258204915592 0.370105208172051 0.866800966962127 0.5 11.3 11 3 abnormal hearing physiology 0.155258204915592 0.370105208172051 0.866800966962127 0.5 11.3 11 3 decreased muscle cell glucose uptake 0.155258204915592 0.370105208172051 0.866800966962127 0.5 11.3 11 3 underdeveloped hair follicles 0.173570654809506 0.408087905329533 0.866800966962127 0.5 11.3 11 3 abnormal Peyer's patch follicle morphology 0.173570654809506 0.408087905329533 0.866800966962127 0.5 11.3 11 3 abnormal white adipose tissue morphology 0.173570654809506 0.408087905329533 0.866800966962127 0.5 11.3 11 3 decreased activity of thyroid 0.173570654809506 0.408087905329533 0.866800966962127 0.5 11.3 11 3 decreased heart rate variability 0.173570654809506 0.408087905329533 0.866800966962127 0.5 11.3 11 3 abnormal neutrophil morphology 0.173570654809506 0.408087905329533 0.866800966962127 0.5 11.3 11 3 decreased pulmonary respiratory rate 0.173570654809506 0.408087905329533 0.866800966962127 0.5 11.3 11 3 abnormal mouth morphology 0.19474310752764 0.450626493000004 0.866800966962127 0.5 11.3 11 3 abnormal meiosis 0.19474310752764 0.450626493000004 0.866800966962127 0.5 11.3 11 3 paternal imprinting 0.19474310752764 0.450626493000004 0.866800966962127 0.5 11.3 11 3 bowed radius 0.19474310752764 0.450626493000004 0.866800966962127 0.5 11.3 11 3 abnormal epididymis epithelium morphology 0.19474310752764 0.450626493000004 0.866800966962127 0.5 11.3 11 3 sepsis 0.19474310752764 0.450626493000004 0.866800966962127 0.5 11.3 11 3 abnormal thoracic cage shape 0.19474310752764 0.450626493000004 0.866800966962127 0.5 11.3 11 3 abnormal lateral semicircular canal morphology 0.284161840701128 0.577209993061859 0.866800966962127 0.5 11.3 11 3 kidney hemorrhage 0.284161840701128 0.577209993061859 0.866800966962127 0.5 11.3 11 3 abnormal grooming behavior 0.284161840701128 0.577209993061859 0.866800966962127 0.5 11.3 11 3 absent trophoblast giant cells 0.284161840701128 0.577209993061859 0.866800966962127 0.5 11.3 11 3 abnormal immune cell physiology 0.284161840701128 0.577209993061859 0.866800966962127 0.5 11.3 11 3 rhinitis 0.284161840701128 0.577209993061859 0.866800966962127 0.5 11.3 11 3 abnormal neuron specification 0.284161840701128 0.577209993061859 0.866800966962127 0.5 11.3 11 3 delayed dark adaptation 0.284161840701128 0.577209993061859 0.866800966962127 0.5 11.3 11 3 intestinal edema 0.284161840701128 0.577209993061859 0.866800966962127 0.5 11.3 11 3 peritoneal inflammation 0.284161840701128 0.577209993061859 0.866800966962127 0.5 11.3 11 3 abnormal hypaxial muscle morphology 0.284161840701128 0.577209993061859 0.866800966962127 0.5 11.3 11 3 lymphedema 0.284161840701128 0.577209993061859 0.866800966962127 0.5 11.3 11 3 abnormal glial cell physiology 0.284161840701128 0.577209993061859 0.866800966962127 0.5 11.3 11 3 increased left ventricle diastolic pressure 0.284161840701128 0.577209993061859 0.866800966962127 0.5 11.3 11 3 increased heart rate variability 0.284161840701128 0.577209993061859 0.866800966962127 0.5 11.3 11 3 abnormal reproductive system development 0.284161840701128 0.577209993061859 0.866800966962127 0.5 11.3 11 3 abnormal cochlear inner hair cell physiology 0.284161840701128 0.577209993061859 0.866800966962127 0.5 11.3 11 3 absent coat pigmentation 0.284161840701128 0.577209993061859 0.866800966962127 0.5 11.3 11 3 ascites 0.284161840701128 0.577209993061859 0.866800966962127 0.5 11.3 11 3 increased susceptibility to atherosclerosis 0.284161840701128 0.577209993061859 0.866800966962127 0.5 11.3 11 3 increased platelet aggregation 0.284161840701128 0.577209993061859 0.866800966962127 0.5 11.3 11 3 increased serotonin level 0.284161840701128 0.577209993061859 0.866800966962127 0.5 11.3 11 3 increased compact bone area 0.284161840701128 0.577209993061859 0.866800966962127 0.5 11.3 11 3 abnormal circadian temperature homeostasis 0.284161840701128 0.577209993061859 0.866800966962127 0.5 11.3 11 3 decreased anxiety-related response 0.00210332603852305 0.0177056633530493 0.859753804629102 0.495934959349593 11.3 11 3 abnormal trabecular bone morphology 0.0024821920175876 0.0199497662156677 0.85951692522295 0.495798319327731 11.3 11 3 increased thermal nociceptive threshold 0.00802741242638317 0.0499824189268433 0.857275681610895 0.494505494505495 11.3 11 3 abnormal B cell differentiation 0.00802741242638317 0.0499824189268433 0.857275681610895 0.494505494505495 11.3 11 3 increased startle reflex 0.00873985821996378 0.0528461778156897 0.857061630254688 0.49438202247191 11.3 11 3 decreased compact bone thickness 0.0226137145031928 0.108698772611965 0.853863639097021 0.492537313432836 11.3 11 3 impaired hematopoiesis 0.0463084212458555 0.183229627327891 0.849804869570713 0.490196078431373 11.3 11 3 abnormal response to novel object 0.0463084212458555 0.183229627327891 0.849804869570713 0.490196078431373 11.3 11 3 abnormal innervation 0.055676777392379 0.204120830896894 0.848358393196976 0.48936170212766 11.3 11 3 decreased bone trabecula number 0.055676777392379 0.204120830896894 0.848358393196976 0.48936170212766 11.3 11 3 decreased insulin secretion 0.0111317341741754 0.0639496276172319 0.847538723251858 0.488888888888889 11.3 11 3 abnormal cartilage development 0.061109089314327 0.218295389972812 0.847538723251858 0.488888888888889 11.3 11 3 short femur 0.0121221284097445 0.0677613357735715 0.847100944985715 0.488636363636364 11.3 11 3 arrest of spermatogenesis 0.0143840518969417 0.0792016295406067 0.846162848701124 0.488095238095238 11.3 11 3 short ulna 0.0737806946449238 0.238195299064566 0.845659479963051 0.48780487804878 11.3 11 3 abnormal circulating hormone level 0.0811723308860012 0.259199195223271 0.844575301142586 0.487179487179487 11.3 11 3 decreased trabecular bone volume 0.0811723308860012 0.259199195223271 0.844575301142586 0.487179487179487 11.3 11 3 increased brown adipose tissue amount 0.0893892461458925 0.279341394205914 0.843373913800989 0.486486486486487 11.3 11 3 impaired skeletal muscle contractility 0.0893892461458925 0.279341394205914 0.843373913800989 0.486486486486487 11.3 11 3 abnormal calcium ion homeostasis 0.0893892461458925 0.279341394205914 0.843373913800989 0.486486486486487 11.3 11 3 abnormal humoral immune response 0.00777836570475767 0.0491750062373935 0.842035225048924 0.485714285714286 11.3 11 3 abnormal motor capabilities/coordination/movement 0.00331957509226209 0.0254859353148208 0.840534270993578 0.484848484848485 11.3 11 3 abnormal motor coordination/ balance 0.0100083238385413 0.0577626578848525 0.840534270993578 0.484848484848485 11.3 11 3 deafness 0.0100083238385413 0.0577626578848525 0.840534270993578 0.484848484848485 11.3 11 3 abnormal skeleton physiology 0.108755906607104 0.328114393796447 0.840534270993578 0.484848484848485 11.3 11 3 abnormal locomotor coordination 0.108755906607104 0.328114393796447 0.840534270993578 0.484848484848485 11.3 11 3 cardiovascular system phenotype 0.108755906607104 0.328114393796447 0.840534270993578 0.484848484848485 11.3 11 3 decreased IgM level 0.0108889588685272 0.0626272489837257 0.839992689633402 0.484536082474227 11.3 11 3 absent mature ovarian follicles 0.120185201530234 0.339666734471754 0.83883964544722 0.483870967741935 11.3 11 3 abnormal microglial cell morphology 0.133008876230046 0.339666734471754 0.836911278446192 0.482758620689655 11.3 11 3 decreased granulocyte number 0.133008876230046 0.339666734471754 0.836911278446192 0.482758620689655 11.3 11 3 absent long term depression 0.133008876230046 0.339666734471754 0.836911278446192 0.482758620689655 11.3 11 3 increased sensitivity to xenobiotic induced morbidity/mortality 0.00824197463555724 0.0509364270955245 0.835280931799868 0.481818181818182 11.3 11 3 abnormal cochlea morphology 0.0538136775149352 0.199495563067662 0.834697227445012 0.481481481481481 11.3 11 3 increased circulating insulin level 0.00178700078371102 0.0155154082006323 0.834295930701047 0.48125 11.3 11 3 decreased body temperature 0.0589483833130958 0.215163761542665 0.833462468232815 0.480769230769231 11.3 11 3 abnormal feces composition 0.163751078433022 0.387380701476122 0.832128928283642 0.48 11.3 11 3 abnormal energy expenditure 0.163751078433022 0.387380701476122 0.832128928283642 0.48 11.3 11 3 abnormal intestinal epithelium morphology 0.0708551993357211 0.230244687586684 0.830684260005372 0.479166666666667 11.3 11 3 cleft secondary palate 0.0161134196126415 0.0863839036345814 0.829915819431824 0.478723404255319 11.3 11 3 abnormal spatial learning 0.00203989604927236 0.0172593245665476 0.829576385558846 0.478527607361963 11.3 11 3 abnormal sleep pattern 0.0777554276379236 0.250377509707877 0.829113968398557 0.478260869565217 11.3 11 3 abnormal cranial nerve morphology 0.182256568526158 0.424298749844471 0.829113968398557 0.478260869565217 11.3 11 3 conjunctivitis 0.182256568526158 0.424298749844471 0.829113968398557 0.478260869565217 11.3 11 3 pancreas inflammation 0.182256568526158 0.424298749844471 0.829113968398557 0.478260869565217 11.3 11 3 abnormal basicranium morphology 0.182256568526158 0.424298749844471 0.829113968398557 0.478260869565217 11.3 11 3 increased total body fat amount 0.00512975270795293 0.0352493366326876 0.827988983366808 0.477611940298507 11.3 11 3 abnormal circadian rhythm 0.0853870260244252 0.271091547205817 0.827400923009303 0.477272727272727 11.3 11 3 abnormal photoreceptor outer segment morphology 0.0853870260244252 0.271091547205817 0.827400923009303 0.477272727272727 11.3 11 3 cochlear hair cell degeneration 0.0853870260244252 0.271091547205817 0.827400923009303 0.477272727272727 11.3 11 3 decreased sensitivity to induced morbidity/mortality 0.0853870260244252 0.271091547205817 0.827400923009303 0.477272727272727 11.3 11 3 increased T cell proliferation 0.0120913821037926 0.0676654960251608 0.826296248879785 0.476635514018692 11.3 11 3 increased incidence of induced tumors 0.20336557954916 0.464742194881521 0.825524730440121 0.476190476190476 11.3 11 3 dry skin 0.20336557954916 0.464742194881521 0.825524730440121 0.476190476190476 11.3 11 3 abnormal stapes morphology 0.20336557954916 0.464742194881521 0.825524730440121 0.476190476190476 11.3 11 3 abnormal maternal nurturing 0.0515482335958021 0.191574221702289 0.824171411209892 0.475409836065574 11.3 11 3 abnormal female reproductive system morphology 0.10321113085942 0.315984846784994 0.823460918614021 0.475 11.3 11 3 impaired ovarian folliculogenesis 0.10321113085942 0.315984846784994 0.823460918614021 0.475 11.3 11 3 abnormal compact bone morphology 0.113621883697338 0.338343220318087 0.821179863437805 0.473684210526316 11.3 11 3 enlarged adrenal glands 0.22759655152208 0.503688987465458 0.821179863437805 0.473684210526316 11.3 11 3 shiny skin 0.22759655152208 0.503688987465458 0.821179863437805 0.473684210526316 11.3 11 3 stereotypic behavior 0.22759655152208 0.503688987465458 0.821179863437805 0.473684210526316 11.3 11 3 abnormal cochlear inner hair cell morphology 0.22759655152208 0.503688987465458 0.821179863437805 0.473684210526316 11.3 11 3 reduced long term potentiation 0.0126302808086792 0.0702074268415408 0.820365200874871 0.473214285714286 11.3 11 3 decreased circulating calcium level 0.067449018899894 0.220038602640638 0.819520914218739 0.472727272727273 11.3 11 3 abnormal learning/memory/conditioning 0.067449018899894 0.220038602640638 0.819520914218739 0.472727272727273 11.3 11 3 abnormal heart left ventricle morphology 0.0412445879321648 0.166551805976071 0.818645357686454 0.472222222222222 11.3 11 3 cochlear outer hair cell degeneration 0.0412445879321648 0.166551805976071 0.818645357686454 0.472222222222222 11.3 11 3 increased susceptibility to bacterial infection induced morbidity/mortality 0.0412445879321648 0.166551805976071 0.818645357686454 0.472222222222222 11.3 11 3 head tilt 0.125205951247763 0.339666734471754 0.818645357686454 0.472222222222222 11.3 11 3 abnormal thrombosis 0.0808759519340223 0.258584743490849 0.815812674787885 0.470588235294118 11.3 11 3 impaired synaptic plasticity 0.138120794040895 0.339666734471754 0.815812674787884 0.470588235294118 11.3 11 3 decreased pancreatic beta cell number 0.138120794040895 0.339666734471754 0.815812674787884 0.470588235294118 11.3 11 3 enhanced behavioral response to cocaine 0.255627404345269 0.547616442895411 0.815812674787884 0.470588235294118 11.3 11 3 organ of Corti degeneration 0.0886305670100707 0.277493436674073 0.813731520005262 0.469387755102041 11.3 11 3 abnormal long term potentiation 0.152550929527721 0.364175083685419 0.812625906526994 0.46875 11.3 11 3 abnormal auditory brainstem response waveform shape 0.152550929527721 0.364175083685419 0.812625906526994 0.46875 11.3 11 3 decreased IgG level 0.0167761330428921 0.0873209883788731 0.812137842919471 0.468468468468468 11.3 11 3 decreased food intake 0.0392217945950436 0.159418650416946 0.811940146268322 0.468354430379747 11.3 11 3 abnormal long bone epiphyseal plate morphology 0.0697402081329755 0.226769631020623 0.809014235831319 0.466666666666667 11.3 11 3 abnormal hair cycle 0.168714169051807 0.398742513554747 0.809014235831319 0.466666666666667 11.3 11 3 abnormal spleen marginal zone morphology 0.168714169051807 0.398742513554747 0.809014235831319 0.466666666666667 11.3 11 3 interdigital webbing 0.288370569776841 0.577209993061859 0.809014235831319 0.466666666666667 11.3 11 3 decreased salivation 0.288370569776841 0.577209993061859 0.809014235831319 0.466666666666667 11.3 11 3 abnormal prostate gland morphology 0.288370569776841 0.577209993061859 0.809014235831319 0.466666666666667 11.3 11 3 hyperpigmentation 0.288370569776841 0.577209993061859 0.809014235831319 0.466666666666667 11.3 11 3 abnormal pup retrieval 0.288370569776841 0.577209993061859 0.809014235831319 0.466666666666667 11.3 11 3 absent egg cylinders 0.288370569776841 0.577209993061859 0.809014235831319 0.466666666666667 11.3 11 3 abnormal respiratory system morphology 0.288370569776841 0.577209993061859 0.809014235831319 0.466666666666667 11.3 11 3 abnormal bronchus morphology 0.288370569776841 0.577209993061859 0.809014235831319 0.466666666666667 11.3 11 3 abnormal energy homeostasis 0.288370569776841 0.577209993061859 0.809014235831319 0.466666666666667 11.3 11 3 bicuspid aortic valve 0.288370569776841 0.577209993061859 0.809014235831319 0.466666666666667 11.3 11 3 abnormal microglial cell activation 0.288370569776841 0.577209993061859 0.809014235831319 0.466666666666667 11.3 11 3 decreased brown adipose tissue mass 0.288370569776841 0.577209993061859 0.809014235831319 0.466666666666667 11.3 11 3 impaired macrophage phagocytosis 0.117071790883366 0.339666734471754 0.806326480895002 0.465116279069767 11.3 11 3 abnormal CNS synaptic transmission 0.027445650607034 0.125383022745633 0.805512009702179 0.464646464646465 11.3 11 3 abnormal seminal vesicle morphology 0.0833067275529111 0.265673698445982 0.804886612179118 0.464285714285714 11.3 11 3 myoclonus 0.186869778069751 0.434631671761108 0.804886612179118 0.464285714285714 11.3 11 3 abnormal renal tubule epithelium morphology 0.186869778069751 0.434631671761108 0.804886612179118 0.464285714285714 11.3 11 3 impaired macrophage chemotaxis 0.141435786107056 0.339666734471754 0.800123969503502 0.461538461538462 11.3 11 3 abnormal Schwann cell morphology 0.20732932711882 0.472931408718996 0.800123969503502 0.461538461538462 11.3 11 3 small seminal vesicle 0.20732932711882 0.472931408718996 0.800123969503502 0.461538461538462 11.3 11 3 abnormal ocular fundus morphology 0.20732932711882 0.472931408718996 0.800123969503502 0.461538461538462 11.3 11 3 pulmonary edema 0.20732932711882 0.472931408718996 0.800123969503502 0.461538461538462 11.3 11 3 abnormal membranous labyrinth morphology 0.327099203749655 0.577209993061859 0.800123969503502 0.461538461538462 11.3 11 3 absent teeth 0.327099203749655 0.577209993061859 0.800123969503502 0.461538461538462 11.3 11 3 uterus hypoplasia 0.327099203749655 0.577209993061859 0.800123969503502 0.461538461538462 11.3 11 3 absent lateral semicircular canal 0.327099203749655 0.577209993061859 0.800123969503502 0.461538461538462 11.3 11 3 abnormal vestibulocochlear ganglion morphology 0.327099203749655 0.577209993061859 0.800123969503502 0.461538461538462 11.3 11 3 abnormal retinal inner plexiform layer morphology 0.327099203749655 0.577209993061859 0.800123969503502 0.461538461538462 11.3 11 3 small otic vesicle 0.327099203749655 0.577209993061859 0.800123969503502 0.461538461538462 11.3 11 3 small interparietal bone 0.327099203749655 0.577209993061859 0.800123969503502 0.461538461538462 11.3 11 3 decreased endocochlear potential 0.327099203749655 0.577209993061859 0.800123969503502 0.461538461538462 11.3 11 3 small pituitary gland 0.327099203749655 0.577209993061859 0.800123969503502 0.461538461538462 11.3 11 3 increased white adipose tissue amount 0.155650150584353 0.370684298304049 0.796519807478712 0.459459459459459 11.3 11 3 decreased body height 0.230471384040887 0.508145708614788 0.794567553048617 0.458333333333333 11.3 11 3 increased stereotypic behavior 0.230471384040887 0.508145708614788 0.794567553048617 0.458333333333333 11.3 11 3 abnormal startle reflex 0.230471384040887 0.508145708614788 0.794567553048617 0.458333333333333 11.3 11 3 abnormal impulse conducting system conduction 0.230471384040887 0.508145708614788 0.794567553048617 0.458333333333333 11.3 11 3 abnormal retinal ganglion layer morphology 0.230471384040887 0.508145708614788 0.794567553048617 0.458333333333333 11.3 11 3 abnormal cellular extravasation 0.230471384040887 0.508145708614788 0.794567553048617 0.458333333333333 11.3 11 3 increased B cell proliferation 0.0929568286615921 0.288496707792527 0.79334325789754 0.457627118644068 11.3 11 3 abnormal eye electrophysiology 0.0276350275109862 0.126132350336841 0.788000879056479 0.454545454545455 11.3 11 3 abnormal aorta morphology 0.189046781961569 0.439079243818303 0.788000879056479 0.454545454545455 11.3 11 3 abnormal abdominal fat pad morphology 0.25676181393269 0.547616442895411 0.788000879056479 0.454545454545455 11.3 11 3 abnormal basisphenoid bone morphology 0.25676181393269 0.547616442895411 0.788000879056479 0.454545454545455 11.3 11 3 abnormal facial nerve morphology 0.25676181393269 0.547616442895411 0.788000879056479 0.454545454545455 11.3 11 3 abnormal cochlear sensory epithelium morphology 0.25676181393269 0.547616442895411 0.788000879056479 0.454545454545455 11.3 11 3 decreased circulating estradiol level 0.25676181393269 0.547616442895411 0.788000879056479 0.454545454545455 11.3 11 3 impaired humoral immune response 0.25676181393269 0.547616442895411 0.788000879056479 0.454545454545455 11.3 11 3 absent semicircular canals 0.37367336388893 0.585885981174787 0.788000879056479 0.454545454545455 11.3 11 3 increased mast cell number 0.37367336388893 0.585885981174787 0.788000879056479 0.454545454545455 11.3 11 3 abnormal sebaceous gland morphology 0.37367336388893 0.585885981174787 0.788000879056479 0.454545454545455 11.3 11 3 abnormal glossopharyngeal ganglion morphology 0.37367336388893 0.585885981174787 0.788000879056479 0.454545454545455 11.3 11 3 social withdrawal 0.37367336388893 0.585885981174787 0.788000879056479 0.454545454545455 11.3 11 3 abnormal food preference 0.37367336388893 0.585885981174787 0.788000879056479 0.454545454545455 11.3 11 3 variable body spotting 0.37367336388893 0.585885981174787 0.788000879056479 0.454545454545455 11.3 11 3 abnormal nerve fiber response 0.37367336388893 0.585885981174787 0.788000879056479 0.454545454545455 11.3 11 3 pulmonary hypertension 0.37367336388893 0.585885981174787 0.788000879056479 0.454545454545455 11.3 11 3 abnormal ureter development 0.37367336388893 0.585885981174787 0.788000879056479 0.454545454545455 11.3 11 3 abnormal hair medulla 0.37367336388893 0.585885981174787 0.788000879056479 0.454545454545455 11.3 11 3 abnormal Bruch membrane morphology 0.37367336388893 0.585885981174787 0.788000879056479 0.454545454545455 11.3 11 3 abnormal platelet aggregation 0.37367336388893 0.585885981174787 0.788000879056479 0.454545454545455 11.3 11 3 abnormal superovulation 0.37367336388893 0.585885981174787 0.788000879056479 0.454545454545455 11.3 11 3 decreased palatine bone horizontal plate size 0.37367336388893 0.585885981174787 0.788000879056479 0.454545454545455 11.3 11 3 decreased core body temperature 0.37367336388893 0.585885981174787 0.788000879056479 0.454545454545455 11.3 11 3 increased pancreatic beta cell proliferation 0.37367336388893 0.585885981174787 0.788000879056479 0.454545454545455 11.3 11 3 abnormal phrenic nerve innervation pattern to diaphragm 0.37367336388893 0.585885981174787 0.788000879056479 0.454545454545455 11.3 11 3 autoimmune response 0.208679201128398 0.475574450578919 0.782917002417405 0.451612903225806 11.3 11 3 abnormal intestine physiology 0.208679201128398 0.475574450578919 0.782917002417405 0.451612903225806 11.3 11 3 perinatal lethality 0.172710504036939 0.407800074790589 0.780120870265915 0.45 11.3 11 3 abnormal hair texture 0.286782471472844 0.577209993061859 0.780120870265915 0.45 11.3 11 3 decreased paired-pulse facilitation 0.286782471472844 0.577209993061859 0.780120870265915 0.45 11.3 11 3 enhanced behavioral response to xenobiotic 0.286782471472844 0.577209993061859 0.780120870265915 0.45 11.3 11 3 abnormal epidermis stratum corneum morphology 0.144586444049782 0.345493544259205 0.778351888700686 0.448979591836735 11.3 11 3 increased neutrophil cell number 0.0249325871304021 0.118763156350876 0.777131901414321 0.448275862068966 11.3 11 3 decreased retinal photoreceptor cell number 0.230631760814511 0.508145708614788 0.777131901414321 0.448275862068966 11.3 11 3 increased double-positive T cell number 0.230631760814511 0.508145708614788 0.777131901414321 0.448275862068966 11.3 11 3 increased grooming behavior 0.189673033302413 0.440328203770185 0.775558759913482 0.447368421052632 11.3 11 3 circling 0.0755937637863559 0.243890385756888 0.77502204104849 0.447058823529412 11.3 11 3 altered response to myocardial infarction 0.172952194361863 0.407983483617955 0.77048974841078 0.444444444444444 11.3 11 3 increased circulating corticosterone level 0.172952194361863 0.407983483617955 0.77048974841078 0.444444444444444 11.3 11 3 abnormal thymus medulla morphology 0.321272803973879 0.577209993061859 0.77048974841078 0.444444444444444 11.3 11 3 increased circulating glycerol level 0.321272803973879 0.577209993061859 0.77048974841078 0.444444444444444 11.3 11 3 decreased fluid intake 0.321272803973879 0.577209993061859 0.77048974841078 0.444444444444444 11.3 11 3 abnormal suckling behavior 0.0822417979216072 0.262445763091723 0.768300857080067 0.443181818181818 11.3 11 3 abnormal response to infection 0.0961851630064299 0.296297947960984 0.768051489713277 0.443037974683544 11.3 11 3 impaired fertilization 0.112925024642199 0.338343220318087 0.767737999309313 0.442857142857143 11.3 11 3 abnormal action potential 0.112925024642199 0.338343220318087 0.767737999309313 0.442857142857143 11.3 11 3 increased double-negative T cell number 0.133215875142453 0.339666734471754 0.767332003540244 0.442622950819672 11.3 11 3 absent corpus luteum 0.158128272552106 0.374435105162649 0.76678547077419 0.442307692307692 11.3 11 3 increased width of hypertrophic chondrocyte zone 0.229251509267365 0.506900559380063 0.764824382613642 0.441176470588235 11.3 11 3 abnormal skin physiology 0.229251509267365 0.506900559380063 0.764824382613642 0.441176470588235 11.3 11 3 decreased inflammatory response 0.0962797211116916 0.296405700823432 0.763610375657112 0.44047619047619 11.3 11 3 abnormal inner ear vestibule morphology 0.282894481304209 0.577209993061859 0.762784850926672 0.44 11.3 11 3 decreased acute inflammation 0.282894481304209 0.577209993061859 0.762784850926672 0.44 11.3 11 3 impaired swimming 0.13303593235338 0.339666734471754 0.76173418308793 0.439393939393939 11.3 11 3 decreased T cell proliferation 0.0393637955764401 0.159865210606359 0.761379227737004 0.439189189189189 11.3 11 3 abnormal lymph node morphology 0.18815887986587 0.437221124396405 0.758450846091861 0.4375 11.3 11 3 abnormal hair shaft morphology 0.18815887986587 0.437221124396405 0.758450846091861 0.4375 11.3 11 3 abnormal crypts of Lieberkuhn morphology 0.25233452348448 0.547616442895411 0.758450846091861 0.4375 11.3 11 3 abnormal bone marrow cell number 0.361191929303998 0.577209993061859 0.758450846091861 0.4375 11.3 11 3 mixed cellular infiltration to dermis 0.361191929303998 0.577209993061859 0.758450846091861 0.4375 11.3 11 3 abnormal extraembryonic endoderm formation 0.361191929303998 0.577209993061859 0.758450846091861 0.4375 11.3 11 3 decreased cochlear coiling 0.361191929303998 0.577209993061859 0.758450846091861 0.4375 11.3 11 3 abnormal level of surface class II molecules 0.361191929303998 0.577209993061859 0.758450846091861 0.4375 11.3 11 3 abnormal pancreatic alpha cell morphology 0.361191929303998 0.577209993061859 0.758450846091861 0.4375 11.3 11 3 abnormal T-helper 2 physiology 0.171475708726544 0.405076757319352 0.75648084389422 0.436363636363636 11.3 11 3 increased autoantibody level 0.226947269771553 0.503147356111174 0.755672637864419 0.435897435897436 11.3 11 3 increased eosinophil cell number 0.156723461343401 0.372911871432204 0.754955680902498 0.435483870967742 11.3 11 3 fragile skeleton 0.314073541168484 0.577209993061859 0.753739971271415 0.434782608695652 11.3 11 3 bidirectional circling 0.314073541168484 0.577209993061859 0.753739971271415 0.434782608695652 11.3 11 3 abnormal circulating insulin level 0.314073541168484 0.577209993061859 0.753739971271415 0.434782608695652 11.3 11 3 decreased epididymis weight 0.314073541168484 0.577209993061859 0.753739971271415 0.434782608695652 11.3 11 3 abnormal lens development 0.314073541168484 0.577209993061859 0.753739971271415 0.434782608695652 11.3 11 3 abnormal chondrocyte physiology 0.314073541168484 0.577209993061859 0.753739971271415 0.434782608695652 11.3 11 3 gastrointestinal hemorrhage 0.277980507456579 0.577209993061859 0.75122750470051 0.433333333333333 11.3 11 3 abnormal synaptic transmission 0.277980507456579 0.577209993061859 0.75122750470051 0.433333333333333 11.3 11 3 increased insulin secretion 0.248673664112423 0.542606796972566 0.749665701156434 0.432432432432432 11.3 11 3 abnormal pancreatic beta cell physiology 0.248673664112423 0.542606796972566 0.749665701156434 0.432432432432432 11.3 11 3 abnormal cued conditioning behavior 0.202971526887646 0.464481760011978 0.747828285222228 0.431372549019608 11.3 11 3 cochlear inner hair cell degeneration 0.202971526887646 0.464481760011978 0.747828285222228 0.431372549019608 11.3 11 3 abnormal cytotoxic T cell physiology 0.244590960176118 0.53794872983032 0.742972257396109 0.428571428571429 11.3 11 3 abnormal stria vascularis morphology 0.306514572965411 0.577209993061859 0.742972257396109 0.428571428571429 11.3 11 3 abnormal anxiety-related response 0.349345140415607 0.577209993061859 0.742972257396109 0.428571428571429 11.3 11 3 hypoalgesia 0.349345140415607 0.577209993061859 0.742972257396109 0.428571428571429 11.3 11 3 enhanced coordination 0.306514572965411 0.577209993061859 0.742972257396109 0.428571428571429 11.3 11 3 abnormal hormone level 0.306514572965411 0.577209993061859 0.742972257396109 0.428571428571429 11.3 11 3 abnormal zigzag hair morphology 0.407814272463379 0.623310600769681 0.742972257396109 0.428571428571429 11.3 11 3 abnormal adrenal gland secretion 0.407814272463379 0.623310600769681 0.742972257396109 0.428571428571429 11.3 11 3 abnormal spleen periarteriolar lymphoid sheath morphology 0.407814272463379 0.623310600769681 0.742972257396109 0.428571428571429 11.3 11 3 abnormal endplate potential 0.407814272463379 0.623310600769681 0.742972257396109 0.428571428571429 11.3 11 3 decreased coping response 0.407814272463379 0.623310600769681 0.742972257396109 0.428571428571429 11.3 11 3 decreased vascular permeability 0.407814272463379 0.623310600769681 0.742972257396109 0.428571428571429 11.3 11 3 skeletal muscle necrosis 0.407814272463379 0.623310600769681 0.742972257396109 0.428571428571429 11.3 11 3 increased lung compliance 0.407814272463379 0.623310600769681 0.742972257396109 0.428571428571429 11.3 11 3 decreased compact bone area 0.407814272463379 0.623310600769681 0.742972257396109 0.428571428571429 11.3 11 3 abnormal immune system physiology 0.0921071626831176 0.287002176580327 0.740975020145044 0.42741935483871 11.3 11 3 polyphagia 0.217383513230914 0.494731463094143 0.738386008893664 0.425925925925926 11.3 11 3 decreased tumor growth/size 0.217383513230914 0.494731463094143 0.738386008893664 0.425925925925926 11.3 11 3 abnormal T cell differentiation 0.125831522044827 0.339666734471754 0.738068150086564 0.425742574257426 11.3 11 3 increased circulating glucose level 0.0835751401327165 0.266018120384047 0.737702950606066 0.425531914893617 11.3 11 3 increased systemic arterial blood pressure 0.240279636776386 0.528700218028535 0.737702950606066 0.425531914893617 11.3 11 3 abnormal T-helper 1 physiology 0.240279636776386 0.528700218028535 0.737702950606066 0.425531914893617 11.3 11 3 decreased IgA level 0.235856580067043 0.51942739523397 0.733446972044877 0.423076923076923 11.3 11 3 abnormal nasal bone morphology 0.338308927706829 0.577209993061859 0.733446972044877 0.423076923076923 11.3 11 3 no spontaneous movement 0.338308927706829 0.577209993061859 0.733446972044877 0.423076923076923 11.3 11 3 abnormal tectorial membrane morphology 0.338308927706829 0.577209993061859 0.733446972044877 0.423076923076923 11.3 11 3 abnormal ovarian follicle morphology 0.261427880386169 0.549938141615725 0.731965260990241 0.422222222222222 11.3 11 3 abnormal cytokine secretion 0.0863864144436263 0.271773246826035 0.731715101981017 0.422077922077922 11.3 11 3 decreased eosinophil cell number 0.2101388943483 0.478681776274172 0.731363315874295 0.421875 11.3 11 3 hyporesponsive to tactile stimuli 0.29158321379243 0.577209993061859 0.72993765638916 0.421052631578947 11.3 11 3 decreased grooming behavior 0.389400987575188 0.597185546604981 0.72993765638916 0.421052631578947 11.3 11 3 unresponsive to tactile stimuli 0.389400987575188 0.597185546604981 0.72993765638916 0.421052631578947 11.3 11 3 abnormal ear morphology 0.389400987575188 0.597185546604981 0.72993765638916 0.421052631578947 11.3 11 3 osteoarthritis 0.389400987575188 0.597185546604981 0.72993765638916 0.421052631578947 11.3 11 3 impaired righting response 0.155633097696638 0.370684298304049 0.72993765638916 0.421052631578947 11.3 11 3 abnormal T cell activation 0.202762715362745 0.464431173540358 0.726238647995296 0.418918918918919 11.3 11 3 abnormal intestinal mucosa morphology 0.284422927597406 0.577209993061859 0.725693832805502 0.418604651162791 11.3 11 3 abnormal systemic arterial blood pressure 0.31842644154042 0.577209993061859 0.722334139135106 0.416666666666667 11.3 11 3 reduced long term depression 0.31842644154042 0.577209993061859 0.722334139135106 0.416666666666667 11.3 11 3 abnormal cardiac muscle contractility 0.373789367688196 0.585885981174787 0.722334139135106 0.416666666666667 11.3 11 3 decreased ovulation rate 0.373789367688196 0.585885981174787 0.722334139135106 0.416666666666667 11.3 11 3 abnormal supraoccipital bone morphology 0.462882104944638 0.674688016649903 0.722334139135106 0.416666666666667 11.3 11 3 abnormal rectum morphology 0.462882104944638 0.674688016649903 0.722334139135106 0.416666666666667 11.3 11 3 abnormal superior cervical ganglion morphology 0.462882104944638 0.674688016649903 0.722334139135106 0.416666666666667 11.3 11 3 abnormal pilomotor reflex 0.462882104944638 0.674688016649903 0.722334139135106 0.416666666666667 11.3 11 3 ear inflammation 0.462882104944638 0.674688016649903 0.722334139135106 0.416666666666667 11.3 11 3 abnormal gastrocnemius morphology 0.462882104944638 0.674688016649903 0.722334139135106 0.416666666666667 11.3 11 3 stria vascularis degeneration 0.462882104944638 0.674688016649903 0.722334139135106 0.416666666666667 11.3 11 3 increased placenta weight 0.462882104944638 0.674688016649903 0.722334139135106 0.416666666666667 11.3 11 3 abnormal amacrine cell morphology 0.462882104944638 0.674688016649903 0.722334139135106 0.416666666666667 11.3 11 3 abnormal palatine bone morphology 0.462882104944638 0.674688016649903 0.722334139135106 0.416666666666667 11.3 11 3 hydrometra 0.462882104944638 0.674688016649903 0.722334139135106 0.416666666666667 11.3 11 3 impaired behavioral response to cocaine 0.462882104944638 0.674688016649903 0.722334139135106 0.416666666666667 11.3 11 3 decreased compensatory feeding amount 0.462882104944638 0.674688016649903 0.722334139135106 0.416666666666667 11.3 11 3 abnormal middle ear morphology 0.360078910954282 0.577209993061859 0.71735252438245 0.413793103448276 11.3 11 3 abnormal social investigation 0.224842785213715 0.502816873188414 0.715110797743755 0.4125 11.3 11 3 thin skin 0.347768857028316 0.577209993061859 0.713836090439399 0.411764705882353 11.3 11 3 decreased regulatory T cell number 0.347768857028316 0.577209993061859 0.713836090439399 0.411764705882353 11.3 11 3 abnormal urinary bladder morphology 0.435087096775109 0.657321076968165 0.713836090439399 0.411764705882353 11.3 11 3 enlarged sebaceous gland 0.435087096775109 0.657321076968165 0.713836090439399 0.411764705882353 11.3 11 3 abnormal melanosome morphology 0.435087096775109 0.657321076968165 0.713836090439399 0.411764705882353 11.3 11 3 pancytopenia 0.435087096775109 0.657321076968165 0.713836090439399 0.411764705882353 11.3 11 3 enhanced long term potentiation 0.285260469974811 0.577209993061859 0.712015080004605 0.410714285714286 11.3 11 3 abnormal response to injury 0.336547348763474 0.577209993061859 0.711221306225335 0.41025641025641 11.3 11 3 abnormal oogenesis 0.413441289519166 0.63074836410851 0.709200791150831 0.409090909090909 11.3 11 3 abnormal female reproductive system physiology 0.413441289519166 0.63074836410851 0.709200791150831 0.409090909090909 11.3 11 3 abnormal limb posture 0.413441289519166 0.63074836410851 0.709200791150831 0.409090909090909 11.3 11 3 abnormal occipital bone morphology 0.413441289519166 0.63074836410851 0.709200791150831 0.409090909090909 11.3 11 3 rough coat 0.413441289519166 0.63074836410851 0.709200791150831 0.409090909090909 11.3 11 3 decreased susceptibility to pharmacologically induced seizures 0.395420030801881 0.606229477115365 0.706282269376548 0.407407407407407 11.3 11 3 abnormal diaphragm morphology 0.379824085474107 0.591296452322191 0.704275785656728 0.40625 11.3 11 3 abnormal serotonin level 0.379824085474107 0.591296452322191 0.704275785656728 0.40625 11.3 11 3 abnormal nervous system electrophysiology 0.262931383695479 0.55286713181953 0.701696020874103 0.404761904761905 11.3 11 3 abnormal muscle morphology 0.353490074205659 0.577209993061859 0.701696020874103 0.404761904761905 11.3 11 3 increased percent body fat/body weight 0.33151409386133 0.577209993061859 0.700108473315564 0.403846153846154 11.3 11 3 impaired behavioral response to xenobiotic 0.397880234480344 0.60981335999375 0.693440773569702 0.4 11.3 11 3 abnormal enteric neuron morphology 0.487443407587738 0.705155845521662 0.693440773569702 0.4 11.3 11 3 altered righting response 0.487443407587738 0.705155845521662 0.693440773569702 0.4 11.3 11 3 joint inflammation 0.487443407587738 0.705155845521662 0.693440773569702 0.4 11.3 11 3 decreased aggression towards males 0.487443407587738 0.705155845521662 0.693440773569702 0.4 11.3 11 3 abnormal rostral migratory stream morphology 0.487443407587738 0.705155845521662 0.693440773569702 0.4 11.3 11 3 abnormal dendritic cell morphology 0.487443407587738 0.705155845521662 0.693440773569702 0.4 11.3 11 3 lactation failure 0.487443407587738 0.705155845521662 0.693440773569702 0.4 11.3 11 3 decreased monocyte cell number 0.325403619064718 0.577209993061859 0.693440773569702 0.4 11.3 11 3 head bobbing 0.38288870526567 0.591296452322191 0.693440773569702 0.4 11.3 11 3 increased pre-B cell number 0.434385958610853 0.657059940434477 0.693440773569702 0.4 11.3 11 3 decreased placenta weight 0.434385958610853 0.657059940434477 0.693440773569702 0.4 11.3 11 3 brain inflammation 0.457813331643418 0.674688016649903 0.693440773569702 0.4 11.3 11 3 abnormal induced retinal neovascularization 0.457813331643418 0.674688016649903 0.693440773569702 0.4 11.3 11 3 nuclear cataracts 0.457813331643418 0.674688016649903 0.693440773569702 0.4 11.3 11 3 abnormal excitatory postsynaptic currents 0.318952501067253 0.577209993061859 0.688995640405794 0.397435897435897 11.3 11 3 abnormal inhibitory postsynaptic currents 0.337843004003658 0.577209993061859 0.688341944352277 0.397058823529412 11.3 11 3 decreased susceptibility to injury 0.337843004003658 0.577209993061859 0.688341944352277 0.397058823529412 11.3 11 3 increased susceptibility to pharmacologically induced seizures 0.304298621549915 0.577209993061859 0.686217432178351 0.395833333333333 11.3 11 3 decreased threshold for auditory brainstem response 0.414508157530132 0.632182122535992 0.684316552864837 0.394736842105263 11.3 11 3 diarrhea 0.432380803511655 0.654424854721777 0.682934095182282 0.393939393939394 11.3 11 3 head tossing 0.432380803511655 0.654424854721777 0.682934095182282 0.393939393939394 11.3 11 3 abnormal NK cell physiology 0.372340272899987 0.585885981174787 0.682072892035772 0.39344262295082 11.3 11 3 decreased circulating progesterone level 0.452947091754891 0.674688016649903 0.6810579026131 0.392857142857143 11.3 11 3 abnormal lymphocyte physiology 0.413407015607887 0.63074836410851 0.678365974144274 0.391304347826087 11.3 11 3 abnormal innervation pattern to muscle 0.477320556316033 0.692121762655863 0.678365974144274 0.391304347826087 11.3 11 3 abnormal crista ampullaris morphology 0.477320556316033 0.692121762655863 0.678365974144274 0.391304347826087 11.3 11 3 abnormal excitatory postsynaptic potential 0.361771707335529 0.577209993061859 0.676527583970441 0.390243902439024 11.3 11 3 blepharoptosis 0.507514374012254 0.7259585999744 0.674178529859432 0.388888888888889 11.3 11 3 increased susceptibility to autoimmune disorder 0.507514374012254 0.7259585999744 0.674178529859432 0.388888888888889 11.3 11 3 abnormal macrophage chemotaxis 0.507514374012254 0.7259585999744 0.674178529859432 0.388888888888889 11.3 11 3 impaired leukocyte tethering or rolling 0.507514374012254 0.7259585999744 0.674178529859432 0.388888888888889 11.3 11 3 decreased macrophage cell number 0.444262668768112 0.670775956637741 0.669800747198007 0.386363636363636 11.3 11 3 impaired natural killer cell mediated cytotoxicity 0.424595107328467 0.647367655212725 0.66910951835673 0.385964912280702 11.3 11 3 abnormal leukocyte migration 0.440359982041556 0.665085279495064 0.666769974586252 0.384615384615385 11.3 11 3 abnormal leukocyte adhesion 0.463233663009294 0.674688016649903 0.666769974586252 0.384615384615385 11.3 11 3 abnormal mast cell morphology 0.547746418191502 0.775480486767991 0.666769974586252 0.384615384615385 11.3 11 3 abnormal digestion 0.547746418191502 0.775480486767991 0.666769974586252 0.384615384615385 11.3 11 3 abnormal otolith morphology 0.547746418191502 0.775480486767991 0.666769974586252 0.384615384615385 11.3 11 3 increased synaptic depression 0.547746418191502 0.775480486767991 0.666769974586252 0.384615384615385 11.3 11 3 abnormal dopaminergic neuron morphology 0.547746418191502 0.775480486767991 0.666769974586252 0.384615384615385 11.3 11 3 abnormal afterhyperpolarization 0.547746418191502 0.775480486767991 0.666769974586252 0.384615384615385 11.3 11 3 vestibular hair cell degeneration 0.547746418191502 0.775480486767991 0.666769974586252 0.384615384615385 11.3 11 3 increased cochlear inner hair cell number 0.547746418191502 0.775480486767991 0.666769974586252 0.384615384615385 11.3 11 3 total cataracts 0.547746418191502 0.775480486767991 0.666769974586252 0.384615384615385 11.3 11 3 increased susceptibility to viral infection induced morbidity/mortality 0.48475962752515 0.702703714142663 0.662847798265156 0.382352941176471 11.3 11 3 increased acute inflammation 0.524562987783608 0.749268120649856 0.660419784352097 0.380952380952381 11.3 11 3 abnormal parietal bone morphology 0.509699868910819 0.728456434309487 0.657573147350579 0.379310344827586 11.3 11 3 increased susceptibility to induced arthritis 0.509699868910819 0.728456434309487 0.657573147350579 0.379310344827586 11.3 11 3 abnormal CD8-positive, alpha-beta T cell physiology 0.509699868910819 0.728456434309487 0.657573147350579 0.379310344827586 11.3 11 3 abnormal wound healing 0.563194294557982 0.776946651389156 0.650100725221595 0.375 11.3 11 3 abnormal intestinal lipid absorption 0.563194294557982 0.776946651389156 0.650100725221595 0.375 11.3 11 3 loose skin 0.563194294557982 0.776946651389156 0.650100725221595 0.375 11.3 11 3 impaired behavioral response to addictive substance 0.563194294557982 0.776946651389156 0.650100725221595 0.375 11.3 11 3 abnormal axon guidance 0.523340699631472 0.747736927244852 0.645061184716002 0.372093023255814 11.3 11 3 abnormal immune system morphology 0.534457629525946 0.758826114980474 0.640678975580703 0.369565217391304 11.3 11 3 decreased susceptibility to induced arthritis 0.533612903857932 0.757843047871314 0.638695449340515 0.368421052631579 11.3 11 3 maternal imprinting 0.576413849433877 0.776946651389156 0.638695449340515 0.368421052631579 11.3 11 3 arrested T cell differentiation 0.564635425676016 0.776946651389156 0.635654042438893 0.366666666666667 11.3 11 3 abnormal CD4-positive, alpha-beta T cell physiology 0.542057027883049 0.769396209334713 0.634840144817333 0.366197183098592 11.3 11 3 arrested B cell differentiation 0.558475302447182 0.776946651389156 0.634244609972288 0.365853658536585 11.3 11 3 decreased susceptibility to viral infection induced morbidity/mortality 0.588061101077575 0.776946651389156 0.630400703245183 0.363636363636364 11.3 11 3 abnormal food intake 0.569230673253555 0.776946651389156 0.628116642726179 0.36231884057971 11.3 11 3 abnormal reflex 0.585641983336843 0.776946651389156 0.626022920583759 0.361111111111111 11.3 11 3 absent atrioventricular cushions 0.625486499151569 0.798100880553747 0.619143547830091 0.357142857142857 11.3 11 3 abnormal prepulse inhibition 0.625486499151569 0.798100880553747 0.619143547830091 0.357142857142857 11.3 11 3 abnormal imprinting 0.625486499151569 0.798100880553747 0.619143547830091 0.357142857142857 11.3 11 3 enlarged stomach 0.625486499151569 0.798100880553747 0.619143547830091 0.357142857142857 11.3 11 3 abnormal positive T cell selection 0.625486499151569 0.798100880553747 0.619143547830091 0.357142857142857 11.3 11 3 abnormal respiratory motile cilium physiology 0.625486499151569 0.798100880553747 0.619143547830091 0.357142857142857 11.3 11 3 decreased response to antigen 0.625486499151569 0.798100880553747 0.619143547830091 0.357142857142857 11.3 11 3 abnormal body temperature homeostasis 0.616894223368879 0.789573899905043 0.615149073327961 0.354838709677419 11.3 11 3 abnormal T cell proliferation 0.616894223368879 0.789573899905043 0.615149073327961 0.354838709677419 11.3 11 3 abnormal vision 0.625091844575369 0.798100880553747 0.611859506090913 0.352941176470588 11.3 11 3 abnormal touch/ nociception 0.633070947894094 0.807571273275159 0.611859506090913 0.352941176470588 11.3 11 3 abnormal dopamine level 0.640275666705662 0.816134112698096 0.606760676873489 0.35 11.3 11 3 decreased skin tensile strength 0.640275666705662 0.816134112698096 0.606760676873489 0.35 11.3 11 3 abnormal male reproductive system physiology 0.640275666705662 0.816134112698096 0.606760676873489 0.35 11.3 11 3 abnormal cochlear ganglion morphology 0.647122724950397 0.824439323080211 0.602991977017132 0.347826086956522 11.3 11 3 increased susceptibility to age related obesity 0.647122724950397 0.824439323080211 0.602991977017132 0.347826086956522 11.3 11 3 delayed wound healing 0.653367670622448 0.832182324973547 0.602991977017132 0.347826086956522 11.3 11 3 abnormal circulating glucose level 0.659864441213751 0.840027020224773 0.597793770318709 0.344827586206897 11.3 11 3 enlarged epididymis 0.659864441213751 0.840027020224773 0.597793770318709 0.344827586206897 11.3 11 3 increased dopamine level 0.665816768866996 0.8471709527144 0.595925664786463 0.34375 11.3 11 3 decreased susceptibility to parasitic infection 0.665816768866996 0.8471709527144 0.595925664786463 0.34375 11.3 11 3 increased alcohol consumption 0.694508044933485 0.879352735071481 0.577867311308085 0.333333333333333 11.3 11 3 abnormal neurotransmitter secretion 0.694508044933485 0.879352735071481 0.577867311308085 0.333333333333333 11.3 11 3 abnormal estrous cycle 0.707478948982619 0.882383183149574 0.577867311308085 0.333333333333333 11.3 11 3 abnormal pain threshold 0.707478948982619 0.882383183149574 0.577867311308085 0.333333333333333 11.3 11 3 increased vasoconstriction 0.698132006166689 0.879352735071481 0.577867311308085 0.333333333333333 11.3 11 3 abnormal sperm axoneme morphology 0.695849234835014 0.879352735071481 0.577867311308085 0.333333333333333 11.3 11 3 decreased vocalization 0.698132006166689 0.879352735071481 0.577867311308085 0.333333333333333 11.3 11 3 apnea 0.700964452679227 0.882190273736189 0.577867311308085 0.333333333333333 11.3 11 3 absent vibrissae 0.710943739904025 0.8835735963084 0.577867311308085 0.333333333333333 11.3 11 3 lung hemorrhage 0.75200334201773 0.90323916623327 0.560871213916671 0.323529411764706 11.3 11 3 increased activated T cell number 0.749498428541609 0.901100696470398 0.551600615339536 0.318181818181818 11.3 11 3 decreased airway responsiveness 0.749498428541609 0.901100696470398 0.551600615339536 0.318181818181818 11.3 11 3 abnormal nail morphology 0.750973258866309 0.90221974471381 0.54745324229187 0.315789473684211 11.3 11 3 altered susceptibility to infection 0.750973258866309 0.90221974471381 0.54745324229187 0.315789473684211 11.3 11 3 abnormal response to novelty 0.750973258866309 0.90221974471381 0.54745324229187 0.315789473684211 11.3 11 3 abnormal Langerhans cell physiology 0.754196113285987 0.905217289167137 0.54175060435133 0.3125 11.3 11 3 abnormal fertilization 0.754196113285987 0.905217289167137 0.54175060435133 0.3125 11.3 11 3 abnormal urinary bladder physiology 0.754196113285987 0.905217289167137 0.54175060435133 0.3125 11.3 11 3 increased susceptibility to parasitic infection 0.883621339045406 1 0.539342823887546 0.311111111111111 11.3 11 3 abnormal retinal cone cell morphology 0.794287798862764 0.9453544974503 0.527617979889991 0.304347826086957 11.3 11 3 increased susceptibility to fungal infection 0.794287798862764 0.9453544974503 0.527617979889991 0.304347826086957 11.3 11 3 abnormal circulating cytokine level 0.798415084078015 0.950039474596537 0.520080580177276 0.3 11.3 11 3 abnormal glutamate-mediated receptor currents 0.804664932199275 0.957018416851875 0.509882921742428 0.294117647058824 11.3 11 3 decreased growth hormone level 0.804664932199275 0.957018416851875 0.509882921742428 0.294117647058824 11.3 11 3 impaired conditioned place preference behavior 0.865205553151312 1 0.485408541498791 0.28 11.3 11 3 abnormal stomach mucosa morphology 0.865205553151312 1 0.485408541498791 0.28 11.3 11 3 abnormal retinal rod cell morphology 0.846517123493222 0.987437910757041 0.481556092756737 0.277777777777778 11.3 11 3 thick dermal layer 0.846517123493222 0.987437910757041 0.481556092756737 0.277777777777778 11.3 11 3 decreased bone strength 0.88667115647318 1 0.478235016254967 0.275862068965517 11.3 11 3 decreased fertilization frequency 0.880639932288548 1 0.456211035243225 0.263157894736842 11.3 11 3 abnormal regulatory T cell physiology 0.899312190011618 1 0.452243982762849 0.260869565217391 11.3 11 3 abnormal single cell response 0.91466160349313 1 0.449452353239622 0.259259259259259 11.3 11 3 abnormal thymocyte activation 0.908048215025393 1 0.433400483481064 0.25 11.3 11 3 abnormal channel response 0.94679043692875 1 0.39400043952824 0.227272727272727 11.3 11 3 decreased cytotoxic T cell cytolysis 0.986125624978774 1 0.356918045219699 0.205882352941176 11.3 11 3 increased circulating luteinizing hormone level 0.991217836353247 1 0.309571773915045 0.178571428571429 11.3 11 3 increased urine microalbumin level 0.000220775430266384 0.00673839119984822 4.383907316299 1 11.1 11 1 cystinuria 0.000220775430266384 0.00673839119984822 4.383907316299 1 11.1 11 1 aminoaciduria 9.89528490052911e-10 2.59100223053328e-07 3.86815351438147 0.882352941176471 11.1 11 1 abnormal hippocampal fimbria morphology 0.00111975236211112 0.0233086527259532 3.65325609691583 0.833333333333333 11.1 11 1 increased cardiac cell glucose uptake 0.00111975236211112 0.0233086527259532 3.65325609691583 0.833333333333333 11.1 11 1 abnormal pillar cell morphology 4.43113141463277e-05 0.00196829274891054 3.5071258530392 0.8 11.1 11 1 dilated uterus 0.000192219394812129 0.00620968499474247 3.40970569045478 0.777777777777778 11.1 11 1 abnormal infrahyoid muscle connection 0.000192219394812129 0.00620968499474247 3.40970569045478 0.777777777777778 11.1 11 1 abnormal coronary sinus connection 0.000192219394812129 0.00620968499474247 3.40970569045478 0.777777777777778 11.1 11 1 anomalous pulmonary venous connection 0.000812007902277744 0.018530914283632 3.28793048722425 0.75 11.1 11 1 failure of atrioventricular cushion closure 0.00331606766473055 0.049696624517412 3.131362368785 0.714285714285714 11.1 11 1 abnormal lacrimal gland morphology 0.00331606766473055 0.049696624517412 3.131362368785 0.714285714285714 11.1 11 1 uremia 0.00331606766473055 0.049696624517412 3.131362368785 0.714285714285714 11.1 11 1 abnormal spinal cord central canal morphology 0.00331606766473055 0.049696624517412 3.131362368785 0.714285714285714 11.1 11 1 coronary fistula 0.00331606766473055 0.049696624517412 3.131362368785 0.714285714285714 11.1 11 1 ductus venosus stenosis 0.00331606766473055 0.049696624517412 3.131362368785 0.714285714285714 11.1 11 1 abnormal inferior vena cava valve morphology 0.000537338249698997 0.0131042048639829 3.0687351214093 0.7 11.1 11 1 thick aortic valve 0.000537338249698997 0.0131042048639829 3.0687351214093 0.7 11.1 11 1 abnormal geniculate ganglion morphology 0.00205158491720898 0.035439704733037 2.92260487753267 0.666666666666667 11.1 11 1 abnormal posterior semicircular canal morphology 0.00205158491720898 0.035439704733037 2.92260487753267 0.666666666666667 11.1 11 1 biliary cyst 0.00205158491720898 0.035439704733037 2.92260487753267 0.666666666666667 11.1 11 1 positive geotaxis 0.00205158491720898 0.035439704733037 2.92260487753267 0.666666666666667 11.1 11 1 dilated bile duct 0.000340742149889052 0.0096868125468459 2.92260487753267 0.666666666666667 11.1 11 1 increased urine calcium level 6.43224266852074e-06 0.000400005090948634 2.84953975559435 0.65 11.1 11 1 absent ductus venosus valve 6.43224266852074e-06 0.000400005090948634 2.84953975559435 0.65 11.1 11 1 irregularly shaped pupil 0.000211182113948444 0.00660774224461325 2.8182261319065 0.642857142857143 11.1 11 1 abnormal glucose tolerance 0.000211182113948444 0.00660774224461325 2.8182261319065 0.642857142857143 11.1 11 1 abnormal renal reabsorbtion 0.000211182113948444 0.00660774224461325 2.8182261319065 0.642857142857143 11.1 11 1 decreased atrioventricular cushion size 0.00124001139146754 0.0247753280022129 2.78975920128118 0.636363636363636 11.1 11 1 focal hepatic necrosis 0.00124001139146754 0.0247753280022129 2.78975920128118 0.636363636363636 11.1 11 1 abnormal palatal shelf elevation 0.00124001139146754 0.0247753280022129 2.78975920128118 0.636363636363636 11.1 11 1 common atrioventricular valve 0.00124001139146754 0.0247753280022129 2.78975920128118 0.636363636363636 11.1 11 1 failure of vascular branching 0.00748950060215189 0.085069099305264 2.73994207268688 0.625 11.1 11 1 abnormal pupil morphology 0.00748950060215189 0.085069099305264 2.73994207268688 0.625 11.1 11 1 tau protein deposits 0.00748950060215189 0.085069099305264 2.73994207268688 0.625 11.1 11 1 abnormal kidney epithelium morphology 0.00748950060215189 0.085069099305264 2.73994207268688 0.625 11.1 11 1 Sertoli cell hypoplasia 0.00748950060215189 0.085069099305264 2.73994207268688 0.625 11.1 11 1 stomach epithelial hyperplasia 0.00748950060215189 0.085069099305264 2.73994207268688 0.625 11.1 11 1 abnormal bronchiole epithelium morphology 0.00748950060215189 0.085069099305264 2.73994207268688 0.625 11.1 11 1 abnormal foramen magnum morphology 0.00748950060215189 0.085069099305264 2.73994207268688 0.625 11.1 11 1 lethality during fetal growth through weaning, incomplete penetrance 0.00748950060215189 0.085069099305264 2.73994207268688 0.625 11.1 11 1 increased circulating ferritin level 0.00748950060215189 0.085069099305264 2.73994207268688 0.625 11.1 11 1 absent hypoglossal canal 0.00748950060215189 0.085069099305264 2.73994207268688 0.625 11.1 11 1 decreased white adipose tissue mass 0.00748950060215189 0.085069099305264 2.73994207268688 0.625 11.1 11 1 increased brain apoptosis 0.00748950060215189 0.085069099305264 2.73994207268688 0.625 11.1 11 1 absent hypoglossal nerve 0.000741308364078366 0.0173145967666191 2.69778911772246 0.615384615384615 11.1 11 1 enlarged pericardium 1.0796612014102e-07 1.45170661540967e-05 2.6569135250297 0.606060606060606 11.1 11 1 decreased circulating parathyroid hormone level 0.00432295491847395 0.0592319450299015 2.6303443897794 0.6 11.1 11 1 absent seminal vesicle 0.00432295491847395 0.0592319450299015 2.6303443897794 0.6 11.1 11 1 abnormal placental transport 0.00432295491847395 0.0592319450299015 2.6303443897794 0.6 11.1 11 1 thick aortic valve cusps 0.00432295491847395 0.0592319450299015 2.6303443897794 0.6 11.1 11 1 abnormal secondary palate development 0.000440736733475359 0.0115724590097519 2.6303443897794 0.6 11.1 11 1 heterochrony 0.000440736733475359 0.0115724590097519 2.6303443897794 0.6 11.1 11 1 abnormal mineral level 0.00249898832967742 0.0401047320649845 2.55727926784108 0.583333333333333 11.1 11 1 amyloidosis 0.00249898832967742 0.0401047320649845 2.55727926784108 0.583333333333333 11.1 11 1 abnormal rostral-caudal body axis extension 0.00249898832967742 0.0401047320649845 2.55727926784108 0.583333333333333 11.1 11 1 pale placenta 0.00249898832967742 0.0401047320649845 2.55727926784108 0.583333333333333 11.1 11 1 abnormal pulmonary valve cusp morphology 0.00249898832967742 0.0401047320649845 2.55727926784108 0.583333333333333 11.1 11 1 prenatal growth retardation 0.00249898832967742 0.0401047320649845 2.55727926784108 0.583333333333333 11.1 11 1 abnormal vitelline vein connection 0.00249898832967742 0.0401047320649845 2.55727926784108 0.583333333333333 11.1 11 1 multiple persisting craniopharyngeal ducts 0.00144814336425159 0.0276034989929183 2.505089895028 0.571428571428571 11.1 11 1 abnormal vitelline vein topology 0.00144814336425159 0.0276034989929183 2.505089895028 0.571428571428571 11.1 11 1 abnormal amino acid level 1.74632184121802e-08 2.71498473751864e-06 2.49085642971534 0.568181818181818 11.1 11 1 abnormal Wolffian duct morphology 5.41579800428869e-05 0.00232272371304623 2.47786065703857 0.565217391304348 11.1 11 1 increased thymus weight 0.000841364248766803 0.0187703459085867 2.46594786541819 0.5625 11.1 11 1 abnormal circulating amino acid level 2.71121431433473e-10 8.51452230669106e-08 2.46114094950119 0.56140350877193 11.1 11 1 abnormal eye muscle morphology 1.89688831670466e-05 0.00101473326619416 2.43550406461056 0.555555555555556 11.1 11 1 abnormal mitral valve morphology 0.000490035321578025 0.0123127561861145 2.43550406461056 0.555555555555556 11.1 11 1 abnormal bile duct morphology 0.000490035321578025 0.0123127561861145 2.43550406461056 0.555555555555556 11.1 11 1 abnormal hypoglossal nerve topology 0.000490035321578025 0.0123127561861145 2.43550406461056 0.555555555555556 11.1 11 1 heart hyperplasia 0.0142868952083305 0.132854773198962 2.43550406461056 0.555555555555556 11.1 11 1 distorted hair follicle pattern 0.0142868952083305 0.132854773198962 2.43550406461056 0.555555555555556 11.1 11 1 abnormal lens vesicle development 0.0142868952083305 0.132854773198962 2.43550406461056 0.555555555555556 11.1 11 1 abnormal postural reflex 0.0142868952083305 0.132854773198962 2.43550406461056 0.555555555555556 11.1 11 1 enlarged otoliths 0.0142868952083305 0.132854773198962 2.43550406461056 0.555555555555556 11.1 11 1 pancreas cysts 0.0142868952083305 0.132854773198962 2.43550406461056 0.555555555555556 11.1 11 1 abnormal stria vascularis vasculature morphology 0.0142868952083305 0.132854773198962 2.43550406461056 0.555555555555556 11.1 11 1 iris coloboma 0.0142868952083305 0.132854773198962 2.43550406461056 0.555555555555556 11.1 11 1 abnormal ductus venosus valve topology 0.0142868952083305 0.132854773198962 2.43550406461056 0.555555555555556 11.1 11 1 pale kidney 6.65412857220081e-06 0.000408694933909865 2.40407820571235 0.548387096774194 11.1 11 1 renal interstitial fibrosis 9.77758885532685e-08 1.36787104044088e-05 2.39122217252673 0.545454545454545 11.1 11 1 premature suture closure 0.00802248715088164 0.0886930523903025 2.39122217252673 0.545454545454545 11.1 11 1 delayed hepatic development 0.00802248715088164 0.0886930523903025 2.39122217252673 0.545454545454545 11.1 11 1 impaired luteinization 0.00802248715088164 0.0886930523903025 2.39122217252673 0.545454545454545 11.1 11 1 abnormal radial glial cell morphology 0.00802248715088164 0.0886930523903025 2.39122217252673 0.545454545454545 11.1 11 1 thin hypoglossal nerve 0.00802248715088164 0.0886930523903025 2.39122217252673 0.545454545454545 11.1 11 1 increased foot pad pigmentation 0.00454961495620966 0.0606818616813486 2.36056547800715 0.538461538461538 11.1 11 1 abnormal coping response 0.00454961495620966 0.0606818616813486 2.36056547800715 0.538461538461538 11.1 11 1 increased circulating ammonia level 0.00454961495620966 0.0606818616813486 2.36056547800715 0.538461538461538 11.1 11 1 herniated liver 0.00259946522799586 0.0411841988786376 2.33808390202613 0.533333333333333 11.1 11 1 polydipsia 1.17359488517197e-05 0.000678910994619831 2.32895076178384 0.53125 11.1 11 1 abnormal interatrial septum morphology 0.00149393765104877 0.0282598472013978 2.32089210862888 0.529411764705882 11.1 11 1 nephrocalcinosis 0.00149393765104877 0.0282598472013978 2.32089210862888 0.529411764705882 11.1 11 1 increased circulating calcium level 1.28521777999416e-08 2.14381927266333e-06 2.31151476677584 0.527272727272727 11.1 11 1 decreased liver regeneration 0.000862627397141634 0.0189892535432727 2.30731964015737 0.526315789473684 11.1 11 1 embryonic lethality between implantation and somite formation, incomplete penetrance 0.000862627397141634 0.0189892535432727 2.30731964015737 0.526315789473684 11.1 11 1 liver degeneration 0.000500025738529934 0.0123762589511762 2.29633240377567 0.523809523809524 11.1 11 1 absent segment of posterior cerebral artery 0.000500025738529934 0.0123762589511762 2.29633240377567 0.523809523809524 11.1 11 1 abnormal atrioventricular cushion morphology 9.91087926463784e-05 0.00370726498808821 2.27313712696985 0.518518518518518 11.1 11 1 small thoracic cage 0.00249783998051951 0.0401047320649845 2.1919536581495 0.5 11.1 11 1 increased adipocyte glucose uptake 0.00249783998051951 0.0401047320649845 2.1919536581495 0.5 11.1 11 1 persistence of hyaloid vascular system 1.14637014294953e-05 0.000678910994619831 2.1919536581495 0.5 11.1 11 1 increased fatty acid level 5.63815794887785e-05 0.00237710472844638 2.1919536581495 0.5 11.1 11 1 abnormal Mullerian duct morphology 0.000281568507860196 0.00824001956826162 2.1919536581495 0.5 11.1 11 1 curly vibrissae 0.000483506442140271 0.0123127561861145 2.1919536581495 0.5 11.1 11 1 intestinal inflammation 0.000832726351472492 0.0186613225161065 2.1919536581495 0.5 11.1 11 1 increased urine glucose level 0.00143919838642834 0.0276034989929183 2.1919536581495 0.5 11.1 11 1 vasculature congestion 0.00435756620722492 0.0592319450299015 2.1919536581495 0.5 11.1 11 1 abnormal intestinal absorption 0.00435756620722492 0.0592319450299015 2.1919536581495 0.5 11.1 11 1 increased cochlear outer hair cell number 0.00435756620722492 0.0592319450299015 2.1919536581495 0.5 11.1 11 1 dystonia 0.00435756620722492 0.0592319450299015 2.1919536581495 0.5 11.1 11 1 abnormal embryonic growth/weight/body size 0.0135459859720859 0.128855220288962 2.1919536581495 0.5 11.1 11 1 abnormal defecation 0.0135459859720859 0.128855220288962 2.1919536581495 0.5 11.1 11 1 reduced cerebellar foliation 0.0135459859720859 0.128855220288962 2.1919536581495 0.5 11.1 11 1 increased fibrosarcoma incidence 0.0135459859720859 0.128855220288962 2.1919536581495 0.5 11.1 11 1 abnormal lateral semicircular canal morphology 0.0242508354981871 0.19303665056557 2.1919536581495 0.5 11.1 11 1 bifid ureter 0.0242508354981871 0.19303665056557 2.1919536581495 0.5 11.1 11 1 abnormal ear physiology 0.0242508354981871 0.19303665056557 2.1919536581495 0.5 11.1 11 1 decreased thyroxine level 0.0242508354981871 0.19303665056557 2.1919536581495 0.5 11.1 11 1 crystalluria 0.0242508354981871 0.19303665056557 2.1919536581495 0.5 11.1 11 1 abnormal heart and great artery attachment 0.0242508354981871 0.19303665056557 2.1919536581495 0.5 11.1 11 1 increased fatty acid oxidation 0.0242508354981871 0.19303665056557 2.1919536581495 0.5 11.1 11 1 increased triglyceride level 0.000164384861346392 0.00552577489998851 2.1919536581495 0.5 11.1 11 1 subcutaneous edema 0.000164384861346392 0.00552577489998851 2.1919536581495 0.5 11.1 11 1 abnormal blood flow velocity 0.00765108654816771 0.0859236017542536 2.1919536581495 0.5 11.1 11 1 absent olfactory bulb 0.00765108654816771 0.0859236017542536 2.1919536581495 0.5 11.1 11 1 abnormal viscerocranium morphology 0.00765108654816771 0.0859236017542536 2.1919536581495 0.5 11.1 11 1 increased cardiomyocyte apoptosis 9.06088321459327e-05 0.00350278892261992 2.12553082002376 0.484848484848485 11.1 11 1 blood in lymph vessels 0.000263633141302106 0.00785374178429926 2.11636904924779 0.482758620689655 11.1 11 1 abnormal type II pneumocyte morphology 0.000450995386273027 0.0117471311345985 2.11077018932915 0.481481481481481 11.1 11 1 embryonic lethality between implantation and placentation, complete penetrance 6.00886443330804e-06 0.000388235072152046 2.09665132518648 0.478260869565217 11.1 11 1 abnormal cranial nerve morphology 0.00132951032965603 0.0260068961721248 2.09665132518648 0.478260869565217 11.1 11 1 oxidative stress 2.73833883230265e-10 8.51452230669106e-08 2.09453349556508 0.477777777777778 11.1 11 1 abnormal triglyceride level 0.0039695313055596 0.0559445276066828 2.07658767614163 0.473684210526316 11.1 11 1 abnormal neural crest cell migration 0.0039695313055596 0.0559445276066828 2.07658767614163 0.473684210526316 11.1 11 1 decreased eye pigmentation 0.0039695313055596 0.0559445276066828 2.07658767614163 0.473684210526316 11.1 11 1 abnormal vagus nerve morphology 0.00690301381271483 0.0825557242533626 2.06301520767012 0.470588235294118 11.1 11 1 common atrium 0.00690301381271483 0.0825557242533626 2.06301520767012 0.470588235294118 11.1 11 1 abnormal survival 0.00690301381271483 0.0825557242533626 2.06301520767012 0.470588235294118 11.1 11 1 kidney cortex cysts 0.000240923425981981 0.00726420632885064 2.05495655451516 0.46875 11.1 11 1 abnormal optic cup morphology 0.000410154289106912 0.0110897695016679 2.04582341427287 0.466666666666667 11.1 11 1 absent incisors 0.0120712552033181 0.121814390743423 2.04582341427287 0.466666666666667 11.1 11 1 vagina atresia 0.0120712552033181 0.121814390743423 2.04582341427287 0.466666666666667 11.1 11 1 abnormal pup retrieval 0.0120712552033181 0.121814390743423 2.04582341427287 0.466666666666667 11.1 11 1 audiogenic seizures 0.0120712552033181 0.121814390743423 2.04582341427287 0.466666666666667 11.1 11 1 placental labyrinth hypoplasia 0.0120712552033181 0.121814390743423 2.04582341427287 0.466666666666667 11.1 11 1 absent myocardial trabeculae 0.0212571611285512 0.177738448091667 2.02334183829185 0.461538461538462 11.1 11 1 abnormal pulmonary alveolus epithelial cell morphology 0.0212571611285512 0.177738448091667 2.02334183829185 0.461538461538462 11.1 11 1 abnormal bile duct development 0.0212571611285512 0.177738448091667 2.02334183829185 0.461538461538462 11.1 11 1 tracheoesophageal fistula 0.0212571611285512 0.177738448091667 2.02334183829185 0.461538461538462 11.1 11 1 increased cochlear inner hair cell number 0.0212571611285512 0.177738448091667 2.02334183829185 0.461538461538462 11.1 11 1 abnormal exocrine pancreas morphology 0.0212571611285512 0.177738448091667 2.02334183829185 0.461538461538462 11.1 11 1 abnormal iris morphology 7.55886273221543e-05 0.00303268887844933 2.02334183829185 0.461538461538462 11.1 11 1 increased circulating serum albumin level 0.000216225027615731 0.00669760185819565 2.0040719160224 0.457142857142857 11.1 11 1 failure to gastrulate 2.38603254977677e-05 0.00121127672807545 2.00134899222346 0.456521739130435 11.1 11 1 increased myocardial infarction size 0.00350987949538891 0.0507606118882553 1.99268514377227 0.454545454545455 11.1 11 1 aphakia 0.00350987949538891 0.0507606118882553 1.99268514377227 0.454545454545455 11.1 11 1 abnormal vascular branching morphogenesis 0.00350987949538891 0.0507606118882553 1.99268514377227 0.454545454545455 11.1 11 1 abnormal basement membrane morphology 0.00350987949538891 0.0507606118882553 1.99268514377227 0.454545454545455 11.1 11 1 pulmonary vascular congestion 0.00350987949538891 0.0507606118882553 1.99268514377227 0.454545454545455 11.1 11 1 embryonic lethality before implantation, incomplete penetrance 0.00350987949538891 0.0507606118882553 1.99268514377227 0.454545454545455 11.1 11 1 abnormal sphenoid bone morphology 0.0377744591209418 0.239398642199599 1.99268514377227 0.454545454545455 11.1 11 1 abnormal stomach epithelium morphology 0.0377744591209418 0.239398642199599 1.99268514377227 0.454545454545455 11.1 11 1 failure of somite differentiation 0.0377744591209418 0.239398642199599 1.99268514377227 0.454545454545455 11.1 11 1 abnormal larynx morphology 0.0377744591209418 0.239398642199599 1.99268514377227 0.454545454545455 11.1 11 1 abnormal bronchiole morphology 0.0377744591209418 0.239398642199599 1.99268514377227 0.454545454545455 11.1 11 1 patent ductus arteriosus 0.0377744591209418 0.239398642199599 1.99268514377227 0.454545454545455 11.1 11 1 pharyngeal arch hypoplasia 0.0377744591209418 0.239398642199599 1.99268514377227 0.454545454545455 11.1 11 1 abnormal crista ampullaris neuroepithelium morphology 0.0377744591209418 0.239398642199599 1.99268514377227 0.454545454545455 11.1 11 1 abnormal palate development 0.0377744591209418 0.239398642199599 1.99268514377227 0.454545454545455 11.1 11 1 decreased palatine bone horizontal plate size 0.0377744591209418 0.239398642199599 1.99268514377227 0.454545454545455 11.1 11 1 increased number of Howell-Jolly bodies 0.0377744591209418 0.239398642199599 1.99268514377227 0.454545454545455 11.1 11 1 aorta dilation 0.0377744591209418 0.239398642199599 1.99268514377227 0.454545454545455 11.1 11 1 waved hair 0.00603980369393971 0.0758788469125001 1.97275829233455 0.45 11.1 11 1 absent placental labyrinth 0.00603980369393971 0.0758788469125001 1.97275829233455 0.45 11.1 11 1 abnormal respiratory system physiology 2.1248841279563e-05 0.00111276826700869 1.968284917522 0.448979591836735 11.1 11 1 abnormal spinal nerve morphology 0.00105344457655082 0.0223969520014543 1.96519983144438 0.448275862068966 11.1 11 1 abnormal urine homeostasis 3.37514084704114e-09 6.71653028561187e-07 1.96362515209226 0.447916666666667 11.1 11 1 decreased cellular sensitivity to gamma-irradiation 0.0104271528784711 0.109128818674484 1.94840325168844 0.444444444444444 11.1 11 1 abnormal eye anterior chamber morphology 0.0104271528784711 0.109128818674484 1.94840325168844 0.444444444444444 11.1 11 1 decreased pulmonary respiratory rate 0.0104271528784711 0.109128818674484 1.94840325168844 0.444444444444444 11.1 11 1 abnormal blood homeostasis 4.59547744710582e-10 1.34485295878538e-07 1.92276636679781 0.43859649122807 11.1 11 1 failure of primitive streak formation 0.000916187491287553 0.0199040732277536 1.91795945088081 0.4375 11.1 11 1 small pancreas 0.0180707910891684 0.15911891268781 1.91795945088081 0.4375 11.1 11 1 embryonic lethality between somite formation and embryo turning, incomplete penetrance 0.0180707910891684 0.15911891268781 1.91795945088081 0.4375 11.1 11 1 decreased adipocyte glucose uptake 0.0180707910891684 0.15911891268781 1.91795945088081 0.4375 11.1 11 1 increased circulating bilirubin level 2.73298497260172e-05 0.00133300002340133 1.902450344809 0.433962264150943 11.1 11 1 increased neuron apoptosis 2.78578084790498e-07 3.22308365542494e-05 1.89428093914154 0.432098765432099 11.1 11 1 increased circulating creatinine level 1.47220872901344e-07 1.87800985303637e-05 1.88609965933794 0.430232558139535 11.1 11 1 abnormal liver development 0.000788770210571345 0.0181672768407057 1.878817421271 0.428571428571429 11.1 11 1 decreased glycogen level 0.000788770210571345 0.0181672768407057 1.878817421271 0.428571428571429 11.1 11 1 trunk curl 0.00884991268736979 0.0957137296079668 1.878817421271 0.428571428571429 11.1 11 1 decreased cochlear outer hair cell number 0.00884991268736979 0.0957137296079668 1.878817421271 0.428571428571429 11.1 11 1 vascular ring 0.00884991268736979 0.0957137296079668 1.878817421271 0.428571428571429 11.1 11 1 abnormal somite shape 0.00260764274306952 0.0411841988786376 1.878817421271 0.428571428571429 11.1 11 1 midline facial cleft 0.0314617170638388 0.226996944682918 1.878817421271 0.428571428571429 11.1 11 1 translucent skin 0.0314617170638388 0.226996944682918 1.878817421271 0.428571428571429 11.1 11 1 absent otoliths 0.0314617170638388 0.226996944682918 1.878817421271 0.428571428571429 11.1 11 1 intestinal obstruction 0.0314617170638388 0.226996944682918 1.878817421271 0.428571428571429 11.1 11 1 amyloid beta deposits 0.0314617170638388 0.226996944682918 1.878817421271 0.428571428571429 11.1 11 1 abnormal ventral body wall morphology 0.0314617170638388 0.226996944682918 1.878817421271 0.428571428571429 11.1 11 1 premature hair loss 0.0314617170638388 0.226996944682918 1.878817421271 0.428571428571429 11.1 11 1 spina bifida occulta 0.0314617170638388 0.226996944682918 1.878817421271 0.428571428571429 11.1 11 1 decreased tongue size 0.0314617170638388 0.226996944682918 1.878817421271 0.428571428571429 11.1 11 1 decreased mean corpuscular hemoglobin 3.92601196922099e-06 0.000283071152853253 1.86960753195104 0.426470588235294 11.1 11 1 abnormal nerve conduction 0.00440153501553708 0.0596665850198827 1.85473001843419 0.423076923076923 11.1 11 1 abnormal myocardial trabeculae morphology 0.000208218889613543 0.00660774224461325 1.85098308910402 0.422222222222222 11.1 11 1 abnormal metabolism 0.000208218889613543 0.00660774224461325 1.85098308910402 0.422222222222222 11.1 11 1 kyphoscoliosis 0.0151236049314976 0.138308703187869 1.84585571212589 0.421052631578947 11.1 11 1 increased liver adenoma incidence 0.0151236049314976 0.138308703187869 1.84585571212589 0.421052631578947 11.1 11 1 abnormal blastocyst morphology 0.0151236049314976 0.138308703187869 1.84585571212589 0.421052631578947 11.1 11 1 increased liver cholesterol level 0.0151236049314976 0.138308703187869 1.84585571212589 0.421052631578947 11.1 11 1 abnormal hindlimb morphology 0.000107537192056693 0.0039050914633726 1.84124107284558 0.42 11.1 11 1 kidney inflammation 0.000107537192056693 0.0039050914633726 1.84124107284558 0.42 11.1 11 1 decreased neuronal precursor cell number 0.00221314848503877 0.037836473240783 1.83841274554474 0.419354838709677 11.1 11 1 abnormal organ of Corti morphology 0.00034535103522807 0.00976205341056619 1.83512399286935 0.418604651162791 11.1 11 1 hydrops fetalis 4.78201585703822e-06 0.000333119218117541 1.82662804845792 0.416666666666667 11.1 11 1 absent mesoderm 2.89097472982546e-05 0.00137087717343731 1.82662804845792 0.416666666666667 11.1 11 1 abnormal kidney physiology 0.000177712173179956 0.00585744383100397 1.82662804845792 0.416666666666667 11.1 11 1 abnormal body weight 0.00743117709810559 0.085069099305264 1.82662804845792 0.416666666666667 11.1 11 1 abnormal inner cell mass apoptosis 0.00743117709810559 0.085069099305264 1.82662804845792 0.416666666666667 11.1 11 1 abnormal glossopharyngeal nerve morphology 0.0550805113701246 0.300796425978452 1.82662804845792 0.416666666666667 11.1 11 1 impaired embryo implantation 0.0550805113701246 0.300796425978452 1.82662804845792 0.416666666666667 11.1 11 1 increased papilloma incidence 0.0550805113701246 0.300796425978452 1.82662804845792 0.416666666666667 11.1 11 1 decreased left ventricle systolic pressure 0.0550805113701246 0.300796425978452 1.82662804845792 0.416666666666667 11.1 11 1 hematuria 0.0550805113701246 0.300796425978452 1.82662804845792 0.416666666666667 11.1 11 1 abnormal fatty acid level 0.0550805113701246 0.300796425978452 1.82662804845792 0.416666666666667 11.1 11 1 decreased renal glomerular filtration rate 0.0550805113701246 0.300796425978452 1.82662804845792 0.416666666666667 11.1 11 1 persistent right dorsal aorta 0.0550805113701246 0.300796425978452 1.82662804845792 0.416666666666667 11.1 11 1 polyuria 2.49958645734443e-06 0.000200571655246589 1.82188356002036 0.415584415584416 11.1 11 1 abnormal lipid homeostasis 1.0840921757095e-09 2.69667928707737e-07 1.82100765446266 0.415384615384615 11.1 11 1 abnormal extraembryonic tissue morphology 9.89816230268779e-08 1.36787104044088e-05 1.80513830671135 0.411764705882353 11.1 11 1 abnormal gastrulation 0.000151003615325771 0.0052169651822619 1.80513830671135 0.411764705882353 11.1 11 1 failure of chorioallantoic fusion 0.000151003615325771 0.0052169651822619 1.80513830671135 0.411764705882353 11.1 11 1 overexpanded pulmonary alveoli 0.00186609289582597 0.0336370005678775 1.80513830671135 0.411764705882353 11.1 11 1 absence seizures 0.0258882351826858 0.197536763855616 1.80513830671135 0.411764705882353 11.1 11 1 abnormal duodenum morphology 0.0258882351826858 0.197536763855616 1.80513830671135 0.411764705882353 11.1 11 1 abnormal embryonic-extraembryonic boundary morphology 0.0258882351826858 0.197536763855616 1.80513830671135 0.411764705882353 11.1 11 1 abnormal ductus venosus valve morphology 0.0258882351826858 0.197536763855616 1.80513830671135 0.411764705882353 11.1 11 1 increased hepatocyte apoptosis 0.00094724165390127 0.0204892488180818 1.79852607848164 0.41025641025641 11.1 11 1 abnormal neural tube closure 1.82173599437388e-06 0.000153647538085712 1.79581745486947 0.409638554216867 11.1 11 1 abnormal circulating lipid level 0.0125468587433566 0.124841244496398 1.79341662939505 0.409090909090909 11.1 11 1 cleft upper lip 0.0125468587433566 0.124841244496398 1.79341662939505 0.409090909090909 11.1 11 1 increased exploration in new environment 2.96540216800728e-06 0.000223528420997519 1.78603631404774 0.407407407407407 11.1 11 1 abnormal heart valve morphology 0.00619708864715657 0.0768840798493863 1.78603631404774 0.407407407407407 11.1 11 1 abnormal fetal cardiomyocyte proliferation 0.00619708864715657 0.0768840798493863 1.78603631404774 0.407407407407407 11.1 11 1 decreased circulating fructosamine level 0.00619708864715657 0.0768840798493863 1.78603631404774 0.407407407407407 11.1 11 1 perimembraneous ventricular septal defect 1.77754371709679e-05 0.000971789010171046 1.77897688197641 0.405797101449275 11.1 11 1 kidney cysts 9.24935853793845e-06 0.000554404322002937 1.77725972282392 0.405405405405405 11.1 11 1 abnormal visceral yolk sac morphology 4.8210218501433e-06 0.000333119218117541 1.77575992558947 0.40506329113924 11.1 11 1 abnormal vibrissa morphology 0.000796412306206106 0.0182587613980432 1.77443867564483 0.404761904761905 11.1 11 1 decreased white adipose tissue amount 2.89330860725462e-05 0.00137087717343731 1.76664921701601 0.402985074626866 11.1 11 1 increased susceptibility to weight loss 0.00130908504240712 0.0259470043265953 1.7535629265196 0.4 11.1 11 1 abnormal pericardium morphology 0.0211794724232028 0.177738448091667 1.7535629265196 0.4 11.1 11 1 abnormal cell proliferation 0.0211794724232028 0.177738448091667 1.7535629265196 0.4 11.1 11 1 abnormal optic stalk morphology 0.0211794724232028 0.177738448091667 1.7535629265196 0.4 11.1 11 1 dilated vasculature 0.0211794724232028 0.177738448091667 1.7535629265196 0.4 11.1 11 1 kidney atrophy 0.0211794724232028 0.177738448091667 1.7535629265196 0.4 11.1 11 1 increased erythrocyte cell number 9.08260846267274e-05 0.00350278892261992 1.7535629265196 0.4 11.1 11 1 small placenta 0.000667372492113369 0.0158309964493287 1.7535629265196 0.4 11.1 11 1 thick pulmonary interalveolar septum 0.00258430801932907 0.0410764613295914 1.7535629265196 0.4 11.1 11 1 decreased triglyceride level 0.00258430801932907 0.0410764613295914 1.7535629265196 0.4 11.1 11 1 abnormal hair cycle 0.00514429137403453 0.0659609525407778 1.7535629265196 0.4 11.1 11 1 abnormal brain vasculature morphology 0.00514429137403453 0.0659609525407778 1.7535629265196 0.4 11.1 11 1 abnormal thyroid gland morphology 0.0103554058204366 0.109128818674484 1.7535629265196 0.4 11.1 11 1 increased cellular sensitivity to ionizing radiation 0.0103554058204366 0.109128818674484 1.7535629265196 0.4 11.1 11 1 altered righting response 0.0443886916375192 0.263665175944796 1.7535629265196 0.4 11.1 11 1 delayed intramembranous bone ossification 0.0443886916375192 0.263665175944796 1.7535629265196 0.4 11.1 11 1 abnormal placenta size 0.0443886916375192 0.263665175944796 1.7535629265196 0.4 11.1 11 1 abnormal rostral migratory stream morphology 0.0443886916375192 0.263665175944796 1.7535629265196 0.4 11.1 11 1 decreased thymocyte apoptosis 0.0443886916375192 0.263665175944796 1.7535629265196 0.4 11.1 11 1 absent chorion 0.0443886916375192 0.263665175944796 1.7535629265196 0.4 11.1 11 1 liver vascular congestion 0.0443886916375192 0.263665175944796 1.7535629265196 0.4 11.1 11 1 ostium primum atrial septal defect 0.0443886916375192 0.263665175944796 1.7535629265196 0.4 11.1 11 1 decreased brown adipose tissue mass 0.0443886916375192 0.263665175944796 1.7535629265196 0.4 11.1 11 1 perinatal lethality, incomplete penetrance 7.33303993539393e-14 4.05354151984276e-11 1.74580379852615 0.398230088495575 11.1 11 1 lethargy 1.52093850919824e-06 0.000132748580408092 1.74413516885014 0.397849462365591 11.1 11 1 pale yolk sac 5.57308889504785e-06 0.000374677260173825 1.74299929443213 0.397590361445783 11.1 11 1 decreased bone marrow cell number 2.05401788912107e-05 0.0010870998934444 1.74155222154344 0.397260273972603 11.1 11 1 abnormal mesoderm development 0.000286363881561265 0.00833134684659236 1.737019880043 0.39622641509434 11.1 11 1 overriding aortic valve 0.000557757675006956 0.0135358265032176 1.73529664603502 0.395833333333333 11.1 11 1 small spleen 2.45075008566656e-06 0.000199876748790019 1.73429300425015 0.395604395604396 11.1 11 1 kidney failure 0.00109133698338406 0.0229380232379035 1.73317265993216 0.395348837209302 11.1 11 1 corneal opacity 3.31908305269315e-05 0.0015432185221634 1.728864857132 0.394366197183099 11.1 11 1 abnormal tooth development 0.00425695186737735 0.0592319450299015 1.7269937912693 0.393939393939394 11.1 11 1 dextrocardia 0.00425695186737735 0.0592319450299015 1.7269937912693 0.393939393939394 11.1 11 1 absent corpus callosum 0.00851967129097761 0.0933598340806467 1.72224930283175 0.392857142857143 11.1 11 1 premature aging 0.00851967129097761 0.0933598340806467 1.72224930283175 0.392857142857143 11.1 11 1 pale liver 2.78164853410972e-05 0.00134356324827144 1.71801773206312 0.391891891891892 11.1 11 1 abnormal allantois morphology 0.00090780214160392 0.0198084019933311 1.71544199333439 0.391304347826087 11.1 11 1 abnormal pulmonary artery morphology 0.017278140870259 0.152951513931563 1.71544199333439 0.391304347826087 11.1 11 1 bidirectional circling 0.017278140870259 0.152951513931563 1.71544199333439 0.391304347826087 11.1 11 1 abnormal hematopoietic stem cell physiology 0.017278140870259 0.152951513931563 1.71544199333439 0.391304347826087 11.1 11 1 abnormal tooth morphology 0.000103251875772136 0.00380502282938056 1.7124637954293 0.390625 11.1 11 1 abnormal cholesterol homeostasis 0.00178064758186518 0.0323311011670776 1.71079309904351 0.390243902439024 11.1 11 1 cortical renal glomerulopathies 0.0357271057399134 0.231134396691897 1.70485284522739 0.388888888888889 11.1 11 1 right pulmonary isomerism 0.0357271057399134 0.231134396691897 1.70485284522739 0.388888888888889 11.1 11 1 abnormal phrenic nerve morphology 0.0357271057399134 0.231134396691897 1.70485284522739 0.388888888888889 11.1 11 1 abnormal white adipose tissue morphology 0.0357271057399134 0.231134396691897 1.70485284522739 0.388888888888889 11.1 11 1 acidosis 0.0357271057399134 0.231134396691897 1.70485284522739 0.388888888888889 11.1 11 1 absent allantois 0.0357271057399134 0.231134396691897 1.70485284522739 0.388888888888889 11.1 11 1 abnormal body wall morphology 0.0357271057399134 0.231134396691897 1.70485284522739 0.388888888888889 11.1 11 1 decreased lactate dehydrogenase level 0.0357271057399134 0.231134396691897 1.70485284522739 0.388888888888889 11.1 11 1 abnormal pregnancy 0.0357271057399134 0.231134396691897 1.70485284522739 0.388888888888889 11.1 11 1 abnormal metanephric mesenchyme morphology 0.0357271057399134 0.231134396691897 1.70485284522739 0.388888888888889 11.1 11 1 polydactyly 2.32455729738386e-06 0.000192744542574745 1.699882428769 0.387755102040816 11.1 11 1 abnormal capillary morphology 0.0069955395144529 0.0828638311533409 1.69699638050284 0.387096774193548 11.1 11 1 delayed bone ossification 3.73529842598234e-05 0.0017048724467213 1.69511082896895 0.386666666666667 11.1 11 1 eyelids open at birth 0.000625084785492406 0.014950946191465 1.68611819857654 0.384615384615385 11.1 11 1 increased leukemia incidence 0.0140765750734989 0.132854773198962 1.68611819857654 0.384615384615385 11.1 11 1 decreased circulating glycerol level 0.0140765750734989 0.132854773198962 1.68611819857654 0.384615384615385 11.1 11 1 short premaxilla 0.0762201052711081 0.377308481317177 1.68611819857654 0.384615384615385 11.1 11 1 absent trabeculae carneae 0.0762201052711081 0.377308481317177 1.68611819857654 0.384615384615385 11.1 11 1 small trigeminal ganglion 0.0762201052711081 0.377308481317177 1.68611819857654 0.384615384615385 11.1 11 1 uterus hypoplasia 0.0762201052711081 0.377308481317177 1.68611819857654 0.384615384615385 11.1 11 1 pup cannibalization 0.0762201052711081 0.377308481317177 1.68611819857654 0.384615384615385 11.1 11 1 excessive scratching 0.0762201052711081 0.377308481317177 1.68611819857654 0.384615384615385 11.1 11 1 abnormal tail bud morphology 0.0762201052711081 0.377308481317177 1.68611819857654 0.384615384615385 11.1 11 1 abnormal telomere length 0.0762201052711081 0.377308481317177 1.68611819857654 0.384615384615385 11.1 11 1 axonal dystrophy 0.0762201052711081 0.377308481317177 1.68611819857654 0.384615384615385 11.1 11 1 abnormal GABAergic neuron morphology 0.0762201052711081 0.377308481317177 1.68611819857654 0.384615384615385 11.1 11 1 vestibular hair cell degeneration 0.0762201052711081 0.377308481317177 1.68611819857654 0.384615384615385 11.1 11 1 increased circulating alanine transaminase level 3.11489144595283e-05 0.00146194197581277 1.68611819857654 0.384615384615385 11.1 11 1 lethality throughout fetal growth and development, complete penetrance 1.14098670397919e-10 4.36646834792035e-08 1.68434333731488 0.384210526315789 11.1 11 1 increased respiratory quotient 0.00121844436916471 0.0247753280022129 1.67894322751877 0.382978723404255 11.1 11 1 decreased hemoglobin content 3.20940579113779e-08 4.69611582673838e-06 1.67894322751877 0.382978723404255 11.1 11 1 abnormal cell cycle 5.96456390182484e-07 6.05585824726093e-05 1.67732106014918 0.382608695652174 11.1 11 1 short maxilla 0.00573700742119489 0.0724406393919913 1.67619985623197 0.382352941176471 11.1 11 1 abnormal learning/memory/conditioning 0.000517757480277923 0.0127517003187261 1.67385552076871 0.381818181818182 11.1 11 1 hydronephrosis 2.1602207247257e-05 0.00111948938599066 1.67005993001867 0.380952380952381 11.1 11 1 abnormal pancreas morphology 0.0023863308284246 0.0401047320649845 1.67005993001867 0.380952380952381 11.1 11 1 abnormal eye pigmentation 0.0287668937991001 0.215860175943474 1.67005993001867 0.380952380952381 11.1 11 1 abnormal bile salt homeostasis 0.0287668937991001 0.215860175943474 1.67005993001867 0.380952380952381 11.1 11 1 increased B cell derived lymphoma incidence 0.00100625038613833 0.0215779985820613 1.66588478019362 0.38 11.1 11 1 decreased oocyte number 0.00100625038613833 0.0215779985820613 1.66588478019362 0.38 11.1 11 1 abnormal placenta morphology 4.13538307773517e-05 0.00187032098288477 1.66477493024013 0.379746835443038 11.1 11 1 lordosis 0.0114621392010376 0.117092695123536 1.66286139583755 0.379310344827586 11.1 11 1 increased mortality induced by gamma-irradiation 0.0114621392010376 0.117092695123536 1.66286139583755 0.379310344827586 11.1 11 1 decreased trophoblast giant cell number 0.0114621392010376 0.117092695123536 1.66286139583755 0.379310344827586 11.1 11 1 abnormal outer ear morphology 0.0114621392010376 0.117092695123536 1.66286139583755 0.379310344827586 11.1 11 1 abnormal intestine morphology 7.92767895653703e-05 0.00315521622470174 1.65877574130232 0.378378378378378 11.1 11 1 increased erythroid progenitor cell number 0.00470135923671635 0.0618763550335023 1.65877574130232 0.378378378378378 11.1 11 1 abnormal respiratory electron transport chain 0.00470135923671635 0.0618763550335023 1.65877574130232 0.378378378378378 11.1 11 1 abnormal developmental patterning 3.43497852688367e-05 0.00158231649733762 1.6573308146984 0.378048780487805 11.1 11 1 albuminuria 0.00196360357026271 0.0348890277216321 1.65614276393518 0.377777777777778 11.1 11 1 abnormal coat/ hair morphology 0.000830370181814301 0.0186613225161065 1.65430464766 0.377358490566038 11.1 11 1 atrioventricular septal defect 0.000830370181814301 0.0186613225161065 1.65430464766 0.377358490566038 11.1 11 1 increased osteoclast cell number 0.000354321783161104 0.00990309478217132 1.65294866024389 0.377049180327869 11.1 11 1 microcephaly 0.00015222182344899 0.0052227832528188 1.65190710469238 0.376811594202899 11.1 11 1 abnormal auditory brainstem response waveform shape 0.00933253751361408 0.100279425767235 1.64396524361213 0.375 11.1 11 1 poor circulation 0.0601794319665298 0.32123677471404 1.64396524361213 0.375 11.1 11 1 disorganized yolk sac vascular plexus 0.0601794319665298 0.32123677471404 1.64396524361213 0.375 11.1 11 1 abnormal olfaction 0.0601794319665298 0.32123677471404 1.64396524361213 0.375 11.1 11 1 decreased aggression towards mice 0.0601794319665298 0.32123677471404 1.64396524361213 0.375 11.1 11 1 decreased circulating triiodothyronine level 0.0601794319665298 0.32123677471404 1.64396524361213 0.375 11.1 11 1 kidney degeneration 0.0601794319665298 0.32123677471404 1.64396524361213 0.375 11.1 11 1 increased heart left ventricle size 0.0601794319665298 0.32123677471404 1.64396524361213 0.375 11.1 11 1 abnormal pulmonary alveolus wall morphology 0.0601794319665298 0.32123677471404 1.64396524361213 0.375 11.1 11 1 decreased fatty acid level 0.0231863191335511 0.187259639106196 1.64396524361213 0.375 11.1 11 1 abnormal liver morphology 2.31892879147467e-09 4.80694614066103e-07 1.64090385582141 0.374301675977654 11.1 11 1 lethality throughout fetal growth and development, incomplete penetrance 2.31892879147467e-09 4.80694614066103e-07 1.64090385582141 0.374301675977654 11.1 11 1 cleft palate 3.15539834931668e-07 3.48846817507788e-05 1.6397821259439 0.374045801526718 11.1 11 1 abnormal cervical vertebrae morphology 0.00132752854776528 0.0260068961721248 1.63322037273884 0.372549019607843 11.1 11 1 increased kidney weight 0.00132752854776528 0.0260068961721248 1.63322037273884 0.372549019607843 11.1 11 1 abnormal homeostasis 0.00315373458844864 0.0484253999306543 1.63122132699498 0.372093023255814 11.1 11 1 decreased oxygen consumption 0.00315373458844864 0.0484253999306543 1.63122132699498 0.372093023255814 11.1 11 1 ovary cysts 0.00759996615866107 0.0859236017542536 1.6283084317682 0.371428571428571 11.1 11 1 impaired adaptive thermogenesis 0.00759996615866107 0.0859236017542536 1.6283084317682 0.371428571428571 11.1 11 1 abnormal apoptosis 0.00109103276187987 0.0229380232379035 1.62366937640704 0.37037037037037 11.1 11 1 increased brain weight 0.0187115670889944 0.163602893264933 1.62366937640704 0.37037037037037 11.1 11 1 abnormal palate morphology 0.0187115670889944 0.163602893264933 1.62366937640704 0.37037037037037 11.1 11 1 atrial septal defect 0.00258252164913166 0.0410764613295914 1.62013966037137 0.369565217391304 11.1 11 1 decreased birth body size 3.34928371125396e-06 0.000248696812887887 1.61512374811016 0.368421052631579 11.1 11 1 absent vitelline blood vessels 0.00089651208442894 0.0196482274010307 1.61512374811016 0.368421052631579 11.1 11 1 decreased tumor incidence 0.0477458145448224 0.269314543492621 1.61512374811016 0.368421052631579 11.1 11 1 decreased germ cell number 0.0477458145448224 0.269314543492621 1.61512374811016 0.368421052631579 11.1 11 1 abnormal optic vesicle formation 0.0477458145448224 0.269314543492621 1.61512374811016 0.368421052631579 11.1 11 1 absent amnion 0.0477458145448224 0.269314543492621 1.61512374811016 0.368421052631579 11.1 11 1 increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 0.0477458145448224 0.269314543492621 1.61512374811016 0.368421052631579 11.1 11 1 decreased susceptibility to weight gain 0.0477458145448224 0.269314543492621 1.61512374811016 0.368421052631579 11.1 11 1 decreased urine osmolality 0.00211481395864335 0.036279998083623 1.610414932518 0.36734693877551 11.1 11 1 decreased circulating creatinine level 0.00211481395864335 0.036279998083623 1.610414932518 0.36734693877551 11.1 11 1 enhanced paired-pulse facilitation 0.0151198405745657 0.138308703187869 1.60743268264297 0.366666666666667 11.1 11 1 liver hemorrhage 0.0151198405745657 0.138308703187869 1.60743268264297 0.366666666666667 11.1 11 1 decreased liver weight 0.000259930981938005 0.00779010021169625 1.605374510194 0.366197183098592 11.1 11 1 microphthalmia 1.11390958956657e-07 1.45834216002466e-05 1.60456738374342 0.366013071895425 11.1 11 1 Leydig cell hyperplasia 0.0050454209581256 0.0652568505120271 1.60386853035329 0.365853658536585 11.1 11 1 decreased kidney weight 0.00173196586543756 0.031562381613743 1.60181228864771 0.365384615384615 11.1 11 1 abnormal vitelline vasculature morphology 4.33450834566351e-06 0.000308059700281085 1.60107919377877 0.365217391304348 11.1 11 1 impaired swimming 0.000497195979153042 0.0123762589511762 1.59414811501782 0.363636363636364 11.1 11 1 abnormal joint morphology 0.00141861863708098 0.0273551461995267 1.59414811501782 0.363636363636364 11.1 11 1 abnormal aorta morphology 0.0122328721686064 0.122451788810497 1.59414811501782 0.363636363636364 11.1 11 1 abnormal ovarian folliculogenesis 0.0122328721686064 0.122451788810497 1.59414811501782 0.363636363636364 11.1 11 1 single kidney 0.0122328721686064 0.122451788810497 1.59414811501782 0.363636363636364 11.1 11 1 intracerebral hemorrhage 0.0380354852595251 0.239830848119312 1.59414811501782 0.363636363636364 11.1 11 1 increased adenoma incidence 0.0380354852595251 0.239830848119312 1.59414811501782 0.363636363636364 11.1 11 1 abnormal erythropoiesis 1.54252800695284e-05 0.000862255824111279 1.58655693351773 0.361904761904762 11.1 11 1 spleen hypoplasia 1.54252800695284e-05 0.000862255824111279 1.58655693351773 0.361904761904762 11.1 11 1 abnormal tibia morphology 0.00335549877444627 0.0498316609040901 1.58566860376772 0.361702127659574 11.1 11 1 hepatic necrosis 0.00335549877444627 0.0498316609040901 1.58566860376772 0.361702127659574 11.1 11 1 increased cellular sensitivity to gamma-irradiation 0.00335549877444627 0.0498316609040901 1.58566860376772 0.361702127659574 11.1 11 1 head tilt 0.00990888946447674 0.106242941995198 1.58307764199686 0.361111111111111 11.1 11 1 increased oxygen consumption 9.83254274900609e-05 0.00370582577093222 1.58024566052638 0.36046511627907 11.1 11 1 abnormal embryo development 1.14460751778656e-06 0.000103534952745238 1.57949601837243 0.360294117647059 11.1 11 1 abnormal interventricular septum morphology 0.0027383809681774 0.0429761681914277 1.57820663386764 0.36 11.1 11 1 abnormal primitive streak morphology 0.0304037078721779 0.226305943939754 1.57820663386764 0.36 11.1 11 1 abnormal eye morphology 9.45895375384779e-07 9.04967210103707e-05 1.5769450778054 0.359712230215827 11.1 11 1 anophthalmia 8.09454585198757e-05 0.00319606076298716 1.57623633844458 0.359550561797753 11.1 11 1 absent gastric milk in neonates 0.000226617110543493 0.00687451295703584 1.57371031867144 0.358974358974359 11.1 11 1 enlarged kidney 0.00223579874746232 0.0380928040021405 1.571589415277 0.358490566037736 11.1 11 1 liver inflammation 5.9034442283643e-06 0.000386442566264637 1.57090012167381 0.358333333333333 11.1 11 1 embryonic lethality, complete penetrance 2.74254713946404e-13 1.36441720188336e-10 1.56666280268992 0.357366771159875 11.1 11 1 shortened head 0.0243737314212259 0.193088079332164 1.5656811843925 0.357142857142857 11.1 11 1 small superior cervical ganglion 0.0243737314212259 0.193088079332164 1.5656811843925 0.357142857142857 11.1 11 1 abnormal renal tubule epithelium morphology 0.0243737314212259 0.193088079332164 1.5656811843925 0.357142857142857 11.1 11 1 abnormal kidney blood vessel morphology 0.101085876497369 0.411877342812783 1.5656811843925 0.357142857142857 11.1 11 1 abnormal pinna reflex 0.101085876497369 0.411877342812783 1.5656811843925 0.357142857142857 11.1 11 1 extended life span 0.101085876497369 0.411877342812783 1.5656811843925 0.357142857142857 11.1 11 1 abnormal adrenal gland secretion 0.101085876497369 0.411877342812783 1.5656811843925 0.357142857142857 11.1 11 1 abnormal fluid regulation 0.101085876497369 0.411877342812783 1.5656811843925 0.357142857142857 11.1 11 1 vascular smooth muscle hypoplasia 0.101085876497369 0.411877342812783 1.5656811843925 0.357142857142857 11.1 11 1 enlarged stomach 0.101085876497369 0.411877342812783 1.5656811843925 0.357142857142857 11.1 11 1 abnormal pancreas development 0.101085876497369 0.411877342812783 1.5656811843925 0.357142857142857 11.1 11 1 split sternum 0.101085876497369 0.411877342812783 1.5656811843925 0.357142857142857 11.1 11 1 lysosomal protein accumulation 0.101085876497369 0.411877342812783 1.5656811843925 0.357142857142857 11.1 11 1 abnormal iris pigmentation 0.101085876497369 0.411877342812783 1.5656811843925 0.357142857142857 11.1 11 1 decreased cornea thickness 0.101085876497369 0.411877342812783 1.5656811843925 0.357142857142857 11.1 11 1 increased lung compliance 0.101085876497369 0.411877342812783 1.5656811843925 0.357142857142857 11.1 11 1 pulmonary alveolar hemorrhage 0.101085876497369 0.411877342812783 1.5656811843925 0.357142857142857 11.1 11 1 abnormal renal tubule epithelial cell primary cilium morphology 0.101085876497369 0.411877342812783 1.5656811843925 0.357142857142857 11.1 11 1 decreased response to antigen 0.101085876497369 0.411877342812783 1.5656811843925 0.357142857142857 11.1 11 1 abnormal enzyme/coenzyme activity 3.0077937824636e-07 3.40085774267192e-05 1.56368668606843 0.356687898089172 11.1 11 1 embryonic lethality during organogenesis, incomplete penetrance 6.39437176426847e-10 1.76733330706865e-07 1.56295826059356 0.356521739130435 11.1 11 1 postnatal lethality 1.69469440290672e-07 2.05636698889291e-05 1.55813573290145 0.355421686746988 11.1 11 1 decreased thymus weight 0.0195882061576276 0.169480566320343 1.55558001546094 0.354838709677419 11.1 11 1 oligodactyly 0.00431004460055522 0.0592319450299015 1.55263384118923 0.354166666666667 11.1 11 1 abnormal gluconeogenesis 0.00350793683385677 0.0507606118882553 1.54726140575259 0.352941176470588 11.1 11 1 small lung 0.00350793683385677 0.0507606118882553 1.54726140575259 0.352941176470588 11.1 11 1 abnormal brown adipose tissue morphology 0.0157760711217401 0.14141613302821 1.54726140575259 0.352941176470588 11.1 11 1 increased susceptibility to weight gain 0.0157760711217401 0.14141613302821 1.54726140575259 0.352941176470588 11.1 11 1 distended urinary bladder 0.0788837211213537 0.383248547440171 1.54726140575259 0.352941176470588 11.1 11 1 hyperlipidemia 0.0788837211213537 0.383248547440171 1.54726140575259 0.352941176470588 11.1 11 1 abnormal testis development 0.0788837211213537 0.383248547440171 1.54726140575259 0.352941176470588 11.1 11 1 abnormal ectoplacental cone morphology 0.0788837211213537 0.383248547440171 1.54726140575259 0.352941176470588 11.1 11 1 abnormal melanosome morphology 0.0788837211213537 0.383248547440171 1.54726140575259 0.352941176470588 11.1 11 1 abnormal tarsal bone morphology 0.0788837211213537 0.383248547440171 1.54726140575259 0.352941176470588 11.1 11 1 increased brain size 0.0788837211213537 0.383248547440171 1.54726140575259 0.352941176470588 11.1 11 1 increased circulating magnesium level 0.0788837211213537 0.383248547440171 1.54726140575259 0.352941176470588 11.1 11 1 abnormal ovary morphology 0.000668243066202821 0.0158309964493287 1.543629336725 0.352112676056338 11.1 11 1 impaired limb coordination 0.00285724313963563 0.0447005805650542 1.54248590758669 0.351851851851852 11.1 11 1 abnormal hepatocyte morphology 2.63080064541521e-05 0.00129586467435056 1.54029175978073 0.351351351351351 11.1 11 1 abnormal long bone metaphysis morphology 0.0127296350045137 0.124856389321554 1.54029175978073 0.351351351351351 11.1 11 1 muscular ventricular septal defect 0.00189941440082545 0.0339913188636928 1.53436756070465 0.35 11.1 11 1 impaired ovarian folliculogenesis 0.0102884088618133 0.109128818674484 1.53436756070465 0.35 11.1 11 1 head bobbing 0.0102884088618133 0.109128818674484 1.53436756070465 0.35 11.1 11 1 abnormal skin pigmentation 0.0102884088618133 0.109128818674484 1.53436756070465 0.35 11.1 11 1 decreased circulating VLDL cholesterol level 0.0620507679949253 0.326059208631231 1.53436756070465 0.35 11.1 11 1 enhanced behavioral response to xenobiotic 0.0620507679949253 0.326059208631231 1.53436756070465 0.35 11.1 11 1 abnormal sperm mitochondrial sheath morphology 0.0620507679949253 0.326059208631231 1.53436756070465 0.35 11.1 11 1 abnormal neuron proliferation 0.0620507679949253 0.326059208631231 1.53436756070465 0.35 11.1 11 1 decreased muscle cell glucose uptake 0.0620507679949253 0.326059208631231 1.53436756070465 0.35 11.1 11 1 enlarged liver 7.27738846046432e-05 0.00296762357301721 1.53436756070465 0.35 11.1 11 1 abnormal liver physiology 7.27738846046432e-05 0.00296762357301721 1.53436756070465 0.35 11.1 11 1 decreased embryo size 1.08245737740125e-17 1.07704509051425e-14 1.53161615443919 0.349372384937238 11.1 11 1 delayed endochondral bone ossification 0.00832749253666572 0.0916576888714866 1.52926999405779 0.348837209302326 11.1 11 1 decreased spleen weight 0.0010340267672358 0.0220784685278888 1.52483732740835 0.347826086956522 11.1 11 1 abnormal cardiovascular development 0.0491060689338002 0.272961902632935 1.52483732740835 0.347826086956522 11.1 11 1 abnormal crista ampullaris morphology 0.0491060689338002 0.272961902632935 1.52483732740835 0.347826086956522 11.1 11 1 abnormal vertebral artery topology 0.0491060689338002 0.272961902632935 1.52483732740835 0.347826086956522 11.1 11 1 abnormal forebrain development 0.000845166044646088 0.0187709869290817 1.5221900403816 0.347222222222222 11.1 11 1 cataract 1.84427220952868e-05 0.000997310243739694 1.52168683706246 0.347107438016529 11.1 11 1 organ of Corti degeneration 0.00547626087907089 0.0695010149831063 1.520947436267 0.346938775510204 11.1 11 1 abnormal long bone hypertrophic chondrocyte zone 0.00547626087907089 0.0695010149831063 1.520947436267 0.346938775510204 11.1 11 1 absent kidney 0.00547626087907089 0.0695010149831063 1.520947436267 0.346938775510204 11.1 11 1 decreased cardiac muscle contractility 7.52343633766545e-05 0.00303268887844933 1.51750637871888 0.346153846153846 11.1 11 1 abnormal snout morphology 0.00444815675831398 0.0598096753313839 1.51750637871888 0.346153846153846 11.1 11 1 liver hypoplasia 0.00444815675831398 0.0598096753313839 1.51750637871888 0.346153846153846 11.1 11 1 kinked neural tube 0.00444815675831398 0.0598096753313839 1.51750637871888 0.346153846153846 11.1 11 1 abnormal leukocyte cell number 0.039047484059714 0.242224030608906 1.51750637871888 0.346153846153846 11.1 11 1 abnormal stomach morphology 0.039047484059714 0.242224030608906 1.51750637871888 0.346153846153846 11.1 11 1 abnormal kidney cortex morphology 0.039047484059714 0.242224030608906 1.51750637871888 0.346153846153846 11.1 11 1 abnormal Schwann cell morphology 0.039047484059714 0.242224030608906 1.51750637871888 0.346153846153846 11.1 11 1 increased thymocyte apoptosis 0.039047484059714 0.242224030608906 1.51750637871888 0.346153846153846 11.1 11 1 embryonic growth arrest 7.22611526220435e-09 1.3314786455358e-06 1.5123523056228 0.344978165938865 11.1 11 1 abnormal retinal pigmentation 0.000310237098915711 0.00887028486842334 1.51169217803414 0.344827586206897 11.1 11 1 abnormal enzyme/coenzyme level 0.00294291811658438 0.0458966069906184 1.51169217803414 0.344827586206897 11.1 11 1 polychromatophilia 0.0311693062739566 0.226996944682918 1.51169217803414 0.344827586206897 11.1 11 1 hemorrhage 4.91390774815096e-09 9.40257347963502e-07 1.51104890476689 0.34468085106383 11.1 11 1 abnormal maternal nurturing 0.00239668197133893 0.0401047320649845 1.50921399413572 0.344262295081967 11.1 11 1 abnormal lens morphology 1.56161427635834e-05 0.000863225669431417 1.50696813997778 0.34375 11.1 11 1 scoliosis 0.0249602230663966 0.19555450355169 1.50696813997778 0.34375 11.1 11 1 increased dopamine level 0.0249602230663966 0.19555450355169 1.50696813997778 0.34375 11.1 11 1 abnormal heart atrium morphology 0.0249602230663966 0.19555450355169 1.50696813997778 0.34375 11.1 11 1 increased fibroblast apoptosis 0.0249602230663966 0.19555450355169 1.50696813997778 0.34375 11.1 11 1 abnormal embryonic epiblast morphology 0.0200418650155204 0.171884903219973 1.5030539370168 0.342857142857143 11.1 11 1 impaired behavioral response to xenobiotic 0.0200418650155204 0.171884903219973 1.5030539370168 0.342857142857143 11.1 11 1 prenatal lethality, incomplete penetrance 5.82346076709192e-11 2.41430977635686e-08 1.49975776610229 0.342105263157895 11.1 11 1 decreased neuron apoptosis 0.0161296892765361 0.143808609589189 1.49975776610229 0.342105263157895 11.1 11 1 abnormal retinal outer nuclear layer morphology 0.0161296892765361 0.143808609589189 1.49975776610229 0.342105263157895 11.1 11 1 abnormal somite development 0.000708664606667079 0.0167090351571977 1.49829743721611 0.341772151898734 11.1 11 1 abnormal brain morphology 1.82215170795116e-06 0.000153647538085712 1.49760808941891 0.341614906832298 11.1 11 1 small kidney 0.000387950315298027 0.0106632752409264 1.4945138578292 0.340909090909091 11.1 11 1 abnormal astrocyte morphology 0.0105070762100659 0.109128818674484 1.4945138578292 0.340909090909091 11.1 11 1 abnormal photoreceptor outer segment morphology 0.0105070762100659 0.109128818674484 1.4945138578292 0.340909090909091 11.1 11 1 decreased blood urea nitrogen level 0.0105070762100659 0.109128818674484 1.4945138578292 0.340909090909091 11.1 11 1 lethality, incomplete penetrance 0.0105070762100659 0.109128818674484 1.4945138578292 0.340909090909091 11.1 11 1 decreased cell proliferation 3.84495013181088e-07 4.06992061824662e-05 1.49289816717209 0.340540540540541 11.1 11 1 abnormal renal glomerulus morphology 9.6273366672612e-05 0.00368430768612496 1.48811532755104 0.339449541284404 11.1 11 1 abnormal bone mineralization 4.36663830332934e-05 0.00195711941973545 1.48545619808479 0.338842975206612 11.1 11 1 pericardial edema 0.00198980074903566 0.0351037543491221 1.4827921805129 0.338235294117647 11.1 11 1 increased circulating free fatty acid level 0.00162242079270272 0.0300057377089072 1.481884163256 0.338028169014085 11.1 11 1 abnormal muscle physiology 0.000482379127075529 0.0123127561861145 1.4777215672918 0.337078651685393 11.1 11 1 abnormal pulmonary alveolus morphology 0.000216746512395879 0.00669760185819565 1.47577077974422 0.336633663366337 11.1 11 1 reduced female fertility 3.20341062981284e-08 4.69611582673838e-06 1.47389987358328 0.336206896551724 11.1 11 1 decreased body length 2.1283440164173e-09 4.80694614066103e-07 1.47196887992521 0.335766423357664 11.1 11 1 abnormal glucose homeostasis 1.07352216237619e-06 0.000100769297317387 1.46933157304527 0.335164835164835 11.1 11 1 embryonic lethality during organogenesis, complete penetrance 2.61979849319735e-17 2.1722495839428e-14 1.46391190740699 0.333928571428571 11.1 11 1 cochlear outer hair cell degeneration 0.00201104816673103 0.035353231906314 1.46130243876633 0.333333333333333 11.1 11 1 incomplete embryo turning 0.00563930835208574 0.07138819097106 1.46130243876633 0.333333333333333 11.1 11 1 abnormal iron level 0.100462028812074 0.411877342812783 1.46130243876633 0.333333333333333 11.1 11 1 abnormal thyroid cartilage morphology 0.100462028812074 0.411877342812783 1.46130243876633 0.333333333333333 11.1 11 1 abnormal thymus cortex morphology 0.100462028812074 0.411877342812783 1.46130243876633 0.333333333333333 11.1 11 1 abnormal neutrophil morphology 0.100462028812074 0.411877342812783 1.46130243876633 0.333333333333333 11.1 11 1 darkened coat color 0.100462028812074 0.411877342812783 1.46130243876633 0.333333333333333 11.1 11 1 decreased tumor latency 0.100462028812074 0.411877342812783 1.46130243876633 0.333333333333333 11.1 11 1 abnormal macrophage chemotaxis 0.100462028812074 0.411877342812783 1.46130243876633 0.333333333333333 11.1 11 1 increased effector memory CD4-positive, alpha-beta T cell number 0.100462028812074 0.411877342812783 1.46130243876633 0.333333333333333 11.1 11 1 increased effector memory CD8-positive, alpha-beta T cell number 0.100462028812074 0.411877342812783 1.46130243876633 0.333333333333333 11.1 11 1 abnormal aerobic respiration 0.100462028812074 0.411877342812783 1.46130243876633 0.333333333333333 11.1 11 1 thymus hypoplasia 2.48781785814233e-05 0.00125019129739981 1.46130243876633 0.333333333333333 11.1 11 1 gliosis 0.00372392965320442 0.0532372127146321 1.46130243876633 0.333333333333333 11.1 11 1 abnormal kidney development 0.0045804315967925 0.0607670591841139 1.46130243876633 0.333333333333333 11.1 11 1 abnormal incisor morphology 0.0045804315967925 0.0607670591841139 1.46130243876633 0.333333333333333 11.1 11 1 abnormal chondrocyte morphology 0.00695028974745303 0.0825557242533626 1.46130243876633 0.333333333333333 11.1 11 1 neurodegeneration 0.00695028974745303 0.0825557242533626 1.46130243876633 0.333333333333333 11.1 11 1 distended abdomen 0.00857605737827745 0.0933607996869372 1.46130243876633 0.333333333333333 11.1 11 1 abnormal trophoblast layer morphology 0.00857605737827745 0.0933607996869372 1.46130243876633 0.333333333333333 11.1 11 1 abnormal dendritic spine morphology 0.00857605737827745 0.0933607996869372 1.46130243876633 0.333333333333333 11.1 11 1 small heart 0.0105959225084306 0.109140195609612 1.46130243876633 0.333333333333333 11.1 11 1 abnormal reproductive system morphology 0.0162491461471642 0.144614493885763 1.46130243876633 0.333333333333333 11.1 11 1 decreased brown adipose tissue amount 0.0313238985152917 0.226996944682918 1.46130243876633 0.333333333333333 11.1 11 1 head tossing 0.0313238985152917 0.226996944682918 1.46130243876633 0.333333333333333 11.1 11 1 abnormal heart tube morphology 0.0391940391236521 0.242224030608906 1.46130243876633 0.333333333333333 11.1 11 1 abnormal lactation 0.0391940391236521 0.242224030608906 1.46130243876633 0.333333333333333 11.1 11 1 abnormal microglial cell physiology 0.0391940391236521 0.242224030608906 1.46130243876633 0.333333333333333 11.1 11 1 abnormal cellular respiration 0.0391940391236521 0.242224030608906 1.46130243876633 0.333333333333333 11.1 11 1 abnormal brain commissure morphology 0.0492154425450738 0.272961902632935 1.46130243876633 0.333333333333333 11.1 11 1 cryptorchism 0.0492154425450738 0.272961902632935 1.46130243876633 0.333333333333333 11.1 11 1 abnormal adrenal gland morphology 0.0620659438339249 0.326059208631231 1.46130243876633 0.333333333333333 11.1 11 1 blindness 0.0620659438339249 0.326059208631231 1.46130243876633 0.333333333333333 11.1 11 1 abnormal primitive streak formation 0.0620659438339249 0.326059208631231 1.46130243876633 0.333333333333333 11.1 11 1 prolonged QT interval 0.0620659438339249 0.326059208631231 1.46130243876633 0.333333333333333 11.1 11 1 decreased ovulation rate 0.0620659438339249 0.326059208631231 1.46130243876633 0.333333333333333 11.1 11 1 increased circulating total protein level 0.0620659438339249 0.326059208631231 1.46130243876633 0.333333333333333 11.1 11 1 abnormal lung saccule morphology 0.0620659438339249 0.326059208631231 1.46130243876633 0.333333333333333 11.1 11 1 abnormal hematopoietic system physiology 0.0786927050928381 0.383248547440171 1.46130243876633 0.333333333333333 11.1 11 1 abnormal stapes morphology 0.0786927050928381 0.383248547440171 1.46130243876633 0.333333333333333 11.1 11 1 abnormal tumor vascularization 0.0786927050928381 0.383248547440171 1.46130243876633 0.333333333333333 11.1 11 1 complete atrioventricular septal defect 0.0786927050928381 0.383248547440171 1.46130243876633 0.333333333333333 11.1 11 1 increased bone ossification 0.0786927050928381 0.383248547440171 1.46130243876633 0.333333333333333 11.1 11 1 abnormal fontanelle morphology 0.129434468927293 0.4866419251151 1.46130243876633 0.333333333333333 11.1 11 1 abnormal bronchus morphology 0.129434468927293 0.4866419251151 1.46130243876633 0.333333333333333 11.1 11 1 abnormal glial cell morphology 0.129434468927293 0.4866419251151 1.46130243876633 0.333333333333333 11.1 11 1 abnormal pericyte morphology 0.129434468927293 0.4866419251151 1.46130243876633 0.333333333333333 11.1 11 1 abnormal olfactory nerve morphology 0.129434468927293 0.4866419251151 1.46130243876633 0.333333333333333 11.1 11 1 abnormal cerebral aqueduct morphology 0.129434468927293 0.4866419251151 1.46130243876633 0.333333333333333 11.1 11 1 bicuspid aortic valve 0.129434468927293 0.4866419251151 1.46130243876633 0.333333333333333 11.1 11 1 abnormal coronary vessel morphology 0.129434468927293 0.4866419251151 1.46130243876633 0.333333333333333 11.1 11 1 abnormal branching involved in lung morphogenesis 0.129434468927293 0.4866419251151 1.46130243876633 0.333333333333333 11.1 11 1 increased rib number 0.00133824430554049 0.0260068961721248 1.46130243876633 0.333333333333333 11.1 11 1 increased urine protein level 0.00133824430554049 0.0260068961721248 1.46130243876633 0.333333333333333 11.1 11 1 small lens 0.0201768774917425 0.172178328510153 1.46130243876633 0.333333333333333 11.1 11 1 failure of heart looping 0.0201768774917425 0.172178328510153 1.46130243876633 0.333333333333333 11.1 11 1 decreased body weight 1.91077168121213e-36 9.50608911403033e-33 1.4589416916924 0.332794830371567 11.1 11 1 abnormal testis morphology 0.000148412184664849 0.0051996522444199 1.44859546103793 0.330434782608696 11.1 11 1 abnormal nervous system morphology 0.00164709472385575 0.0301260891587587 1.44280493954144 0.329113924050633 11.1 11 1 abnormal myocardium layer morphology 0.00164709472385575 0.0301260891587587 1.44280493954144 0.329113924050633 11.1 11 1 decreased percent body fat/body weight 0.00247620670099651 0.0401047320649845 1.4412845971394 0.328767123287671 11.1 11 1 embryonic lethality between somite formation and embryo turning, complete penetrance 0.0030391672214637 0.0469560774123662 1.4404266896411 0.328571428571429 11.1 11 1 enlarged heart 1.59698172563938e-07 1.98624602126398e-05 1.43610756913243 0.327586206896552 11.1 11 1 glomerulosclerosis 0.00695293436425305 0.0825557242533626 1.43610756913243 0.327586206896552 11.1 11 1 prenatal lethality, complete penetrance 1.06357864036975e-08 1.88975133422839e-06 1.43502002080291 0.327338129496403 11.1 11 1 distended pericardium 0.0105810376794026 0.109140195609612 1.43320046879006 0.326923076923077 11.1 11 1 abnormal hair growth 0.0105810376794026 0.109140195609612 1.43320046879006 0.326923076923077 11.1 11 1 abnormal placenta vasculature 0.0105810376794026 0.109140195609612 1.43320046879006 0.326923076923077 11.1 11 1 cardiac hypertrophy 0.000600737295726188 0.0144380098852067 1.431479940016 0.326530612244898 11.1 11 1 increased T cell derived lymphoma incidence 0.0130781826923627 0.125849050086082 1.431479940016 0.326530612244898 11.1 11 1 decreased circulating glucose level 1.2927553402995e-08 2.14381927266333e-06 1.42987657986813 0.326164874551971 11.1 11 1 pallor 6.42785181109122e-06 0.000400005090948634 1.42790124016596 0.325714285714286 11.1 11 1 abnormal blood circulation 0.0200733927177496 0.171884903219973 1.4273186611206 0.325581395348837 11.1 11 1 abnormal cell morphology 0.00026989507639172 0.00794513612454915 1.42284711143038 0.324561403508772 11.1 11 1 malocclusion 0.0310501373285759 0.226996944682918 1.42180777825913 0.324324324324324 11.1 11 1 abnormal chromosome morphology 0.0310501373285759 0.226996944682918 1.42180777825913 0.324324324324324 11.1 11 1 abnormal hair follicle development 0.0310501373285759 0.226996944682918 1.42180777825913 0.324324324324324 11.1 11 1 increased blood urea nitrogen level 4.5518297609033e-05 0.00200401354517645 1.42099064735209 0.324137931034483 11.1 11 1 abnormal axon morphology 0.000401789338665968 0.0109229615293071 1.42071070435616 0.324074074074074 11.1 11 1 atelectasis 0.00371802488524501 0.0532372127146321 1.420138989787 0.323943661971831 11.1 11 1 impaired balance 0.000598878234467255 0.0144380098852067 1.41832295527321 0.323529411764706 11.1 11 1 enlarged liver sinusoidal spaces 0.0387598159643817 0.242224030608906 1.41832295527321 0.323529411764706 11.1 11 1 abnormal endoderm development 0.0387598159643817 0.242224030608906 1.41832295527321 0.323529411764706 11.1 11 1 abnormal spleen red pulp morphology 0.0387598159643817 0.242224030608906 1.41832295527321 0.323529411764706 11.1 11 1 hyperactivity 1.24741402792429e-10 4.43277484923095e-08 1.41797541228 0.323450134770889 11.1 11 1 increased mean corpuscular hemoglobin 0.00073152842430685 0.0171667637307858 1.4170205466825 0.323232323232323 11.1 11 1 hypoglycemia 0.00109272593113229 0.0229380232379035 1.41416365041903 0.32258064516129 11.1 11 1 prenatal lethality 0.00690584738868433 0.0825557242533626 1.41416365041903 0.32258064516129 11.1 11 1 abnormal cranial ganglia morphology 0.0485301500598542 0.271278086008736 1.41416365041903 0.32258064516129 11.1 11 1 absent mature ovarian follicles 0.0485301500598542 0.271278086008736 1.41416365041903 0.32258064516129 11.1 11 1 abnormal postnatal growth/weight/body size 0.0485301500598542 0.271278086008736 1.41416365041903 0.32258064516129 11.1 11 1 abnormal retinal photoreceptor layer morphology 0.0485301500598542 0.271278086008736 1.41416365041903 0.32258064516129 11.1 11 1 decreased double-negative T cell number 0.0485301500598542 0.271278086008736 1.41416365041903 0.32258064516129 11.1 11 1 preaxial polydactyly 0.0485301500598542 0.271278086008736 1.41416365041903 0.32258064516129 11.1 11 1 abnormal intestine physiology 0.0485301500598542 0.271278086008736 1.41416365041903 0.32258064516129 11.1 11 1 abnormal mitochondrial ATP synthesis coupled electron transport 0.0485301500598542 0.271278086008736 1.41416365041903 0.32258064516129 11.1 11 1 decreased hematocrit 5.51519741725437e-05 0.0023451373633197 1.41125783469899 0.321917808219178 11.1 11 1 short limbs 0.00163503808193985 0.0301260891587587 1.41091269949853 0.32183908045977 11.1 11 1 increased body weight 7.48546177687134e-07 7.44803446798699e-05 1.40911306595325 0.321428571428571 11.1 11 1 abnormal neuron differentiation 0.000399470712536358 0.0109195977740021 1.40911306595325 0.321428571428571 11.1 11 1 abnormal eye development 0.0104840559835635 0.109128818674484 1.40911306595325 0.321428571428571 11.1 11 1 decreased circulating progesterone level 0.0609825688668966 0.324826852369176 1.40911306595325 0.321428571428571 11.1 11 1 decreased heart weight 0.00245126341832529 0.0401047320649845 1.40718012621943 0.320987654320988 11.1 11 1 weight loss 1.38500014988055e-05 0.000791997212144337 1.40285034121568 0.32 11.1 11 1 spleen hyperplasia 0.00368324290345251 0.0529599232505094 1.40285034121568 0.32 11.1 11 1 mandible hypoplasia 0.0769658195806292 0.379866024219871 1.40285034121568 0.32 11.1 11 1 abnormal nest building behavior 0.0769658195806292 0.379866024219871 1.40285034121568 0.32 11.1 11 1 abnormal embryonic tissue morphology 6.66129747661773e-05 0.0027616629121811 1.40165744126567 0.319727891156463 11.1 11 1 abnormal cell nucleus morphology 0.0197927438763483 0.170656673803869 1.39911935626564 0.319148936170213 11.1 11 1 neuron degeneration 0.0197927438763483 0.170656673803869 1.39911935626564 0.319148936170213 11.1 11 1 increased grip strength 0.00161826660163721 0.0300057377089072 1.39706936453485 0.318681318681319 11.1 11 1 insulin resistance 0.000177783722307859 0.00585744383100397 1.39487960064059 0.318181818181818 11.1 11 1 teratozoospermia 0.00197928221862689 0.035042452091348 1.39487960064059 0.318181818181818 11.1 11 1 abnormal circadian rhythm 0.0245376737546685 0.193462641726586 1.39487960064059 0.318181818181818 11.1 11 1 muscular atrophy 0.0245376737546685 0.193462641726586 1.39487960064059 0.318181818181818 11.1 11 1 abnormal enterocyte morphology 0.0976660743483841 0.408309848641354 1.39487960064059 0.318181818181818 11.1 11 1 intestinal ulcer 0.0976660743483841 0.408309848641354 1.39487960064059 0.318181818181818 11.1 11 1 increased body size 0.0976660743483841 0.408309848641354 1.39487960064059 0.318181818181818 11.1 11 1 abnormal germ layer development 0.0976660743483841 0.408309848641354 1.39487960064059 0.318181818181818 11.1 11 1 abnormal chorion morphology 0.0976660743483841 0.408309848641354 1.39487960064059 0.318181818181818 11.1 11 1 abnormal cochlear sensory epithelium morphology 0.0976660743483841 0.408309848641354 1.39487960064059 0.318181818181818 11.1 11 1 decreased cardiac output 0.0976660743483841 0.408309848641354 1.39487960064059 0.318181818181818 11.1 11 1 prolonged PR interval 0.0976660743483841 0.408309848641354 1.39487960064059 0.318181818181818 11.1 11 1 abnormal blood-brain barrier function 0.0976660743483841 0.408309848641354 1.39487960064059 0.318181818181818 11.1 11 1 decreased circulating estradiol level 0.0976660743483841 0.408309848641354 1.39487960064059 0.318181818181818 11.1 11 1 abnormal occipital bone morphology 0.0976660743483841 0.408309848641354 1.39487960064059 0.318181818181818 11.1 11 1 increased circulating creatine kinase level 0.0976660743483841 0.408309848641354 1.39487960064059 0.318181818181818 11.1 11 1 abnormal lung development 0.00242195408855579 0.0401047320649845 1.39253526517733 0.317647058823529 11.1 11 1 circling 0.00242195408855579 0.0401047320649845 1.39253526517733 0.317647058823529 11.1 11 1 cardiac fibrosis 0.00242195408855579 0.0401047320649845 1.39253526517733 0.317647058823529 11.1 11 1 anemia 2.85275675075138e-06 0.000221647423726467 1.39204639901437 0.317535545023697 11.1 11 1 abnormal blood vessel morphology 9.75432313642414e-05 0.00370440897738245 1.39075680379141 0.317241379310345 11.1 11 1 liver fibrosis 0.0304773834049518 0.226305943939754 1.39001939297285 0.317073170731707 11.1 11 1 abnormal cell differentiation 0.0304773834049518 0.226305943939754 1.39001939297285 0.317073170731707 11.1 11 1 intracranial hemorrhage 0.0103227769207424 0.109128818674484 1.38823731682802 0.316666666666667 11.1 11 1 abnormal placenta labyrinth morphology 0.00363197975502444 0.0523742008152075 1.38731244186677 0.316455696202532 11.1 11 1 ventricular septal defect 0.000175604750596164 0.00585744383100397 1.38608834265336 0.316176470588235 11.1 11 1 abnormal heart morphology 1.28803305042478e-06 0.00011442793617613 1.38539062376548 0.316017316017316 11.1 11 1 increased hepatocellular carcinoma incidence 0.0127200933519379 0.124856389321554 1.38439178409442 0.315789473684211 11.1 11 1 increased macrophage cell number 0.0127200933519379 0.124856389321554 1.38439178409442 0.315789473684211 11.1 11 1 decreased hair follicle number 0.0379364979679788 0.239814583723881 1.38439178409442 0.315789473684211 11.1 11 1 impaired branching involved in ureteric bud morphogenesis 0.0379364979679788 0.239814583723881 1.38439178409442 0.315789473684211 11.1 11 1 irregular coat pigmentation 0.124792589243113 0.477204559173318 1.38439178409442 0.315789473684211 11.1 11 1 enlarged adrenal glands 0.124792589243113 0.477204559173318 1.38439178409442 0.315789473684211 11.1 11 1 short vibrissae 0.124792589243113 0.477204559173318 1.38439178409442 0.315789473684211 11.1 11 1 abnormal stationary movement 0.124792589243113 0.477204559173318 1.38439178409442 0.315789473684211 11.1 11 1 stereotypic behavior 0.124792589243113 0.477204559173318 1.38439178409442 0.315789473684211 11.1 11 1 oliguria 0.124792589243113 0.477204559173318 1.38439178409442 0.315789473684211 11.1 11 1 abnormal photoreceptor inner segment morphology 0.124792589243113 0.477204559173318 1.38439178409442 0.315789473684211 11.1 11 1 increased left ventricle weight 0.124792589243113 0.477204559173318 1.38439178409442 0.315789473684211 11.1 11 1 decreased liver glycogen level 0.124792589243113 0.477204559173318 1.38439178409442 0.315789473684211 11.1 11 1 seminiferous tubule degeneration 0.00545906284607481 0.0695010149831063 1.38123107225859 0.315068493150685 11.1 11 1 increased circulating alkaline phosphatase level 5.28881717353644e-05 0.00228798829898641 1.38011896994598 0.314814814814815 11.1 11 1 diluted coat color 0.0156917858760054 0.14139536886715 1.38011896994598 0.314814814814815 11.1 11 1 polyphagia 0.0156917858760054 0.14139536886715 1.38011896994598 0.314814814814815 11.1 11 1 abnormal long bone epiphyseal plate proliferative zone 0.0156917858760054 0.14139536886715 1.38011896994598 0.314814814814815 11.1 11 1 abnormal neuronal precursor proliferation 0.0156917858760054 0.14139536886715 1.38011896994598 0.314814814814815 11.1 11 1 axon degeneration 0.0156917858760054 0.14139536886715 1.38011896994598 0.314814814814815 11.1 11 1 premature death 2.2149295592962e-20 5.14946151488405e-17 1.37983610071664 0.314750290360046 11.1 11 1 increased startle reflex 0.00238382723725893 0.0401047320649845 1.37920679613901 0.314606741573034 11.1 11 1 decreased body size 6.31627242584006e-19 7.85586382963857e-16 1.37889816590357 0.31453634085213 11.1 11 1 abnormal retina morphology 4.96203116025445e-06 0.000338165822222821 1.3777994422654 0.314285714285714 11.1 11 1 abnormal artery morphology 0.0473388768159431 0.269314543492621 1.3777994422654 0.314285714285714 11.1 11 1 abnormal midbrain development 0.0473388768159431 0.269314543492621 1.3777994422654 0.314285714285714 11.1 11 1 decreased bone mineralization 0.0473388768159431 0.269314543492621 1.3777994422654 0.314285714285714 11.1 11 1 cochlear inner hair cell degeneration 0.0193818963186133 0.167987690217947 1.37534347178008 0.313725490196078 11.1 11 1 kyphosis 0.000115218485938022 0.00415370990972215 1.37362429244035 0.313333333333333 11.1 11 1 decreased litter size 1.75915860511037e-07 2.08376525248193e-05 1.37289624140325 0.313167259786477 11.1 11 1 deafness 0.00156838918417577 0.0292237310534624 1.37273865459868 0.313131313131313 11.1 11 1 reduced male fertility 2.70043411199339e-06 0.00021324856678043 1.37117805928295 0.312775330396476 11.1 11 1 decreased circulating HDL cholesterol level 0.000378865603619945 0.0104714243222735 1.36997103634344 0.3125 11.1 11 1 decreased circulating LDL cholesterol level 0.0101117775352403 0.108185146748001 1.36997103634344 0.3125 11.1 11 1 abnormal vertebral body morphology 0.0592437532386985 0.319325755539031 1.36997103634344 0.3125 11.1 11 1 increased circulating follicle stimulating hormone level 0.0592437532386985 0.319325755539031 1.36997103634344 0.3125 11.1 11 1 neonatal lethality 0.0592437532386985 0.319325755539031 1.36997103634344 0.3125 11.1 11 1 abnormal depression-related behavior 0.0592437532386985 0.319325755539031 1.36997103634344 0.3125 11.1 11 1 abnormal tympanic ring morphology 0.160914031182186 0.501383658457645 1.36997103634344 0.3125 11.1 11 1 abnormal bone marrow cell number 0.160914031182186 0.501383658457645 1.36997103634344 0.3125 11.1 11 1 abnormal hair follicle orientation 0.160914031182186 0.501383658457645 1.36997103634344 0.3125 11.1 11 1 delayed hair appearance 0.160914031182186 0.501383658457645 1.36997103634344 0.3125 11.1 11 1 abnormal extraembryonic endoderm formation 0.160914031182186 0.501383658457645 1.36997103634344 0.3125 11.1 11 1 white spotting 0.160914031182186 0.501383658457645 1.36997103634344 0.3125 11.1 11 1 increased intestinal adenocarcinoma incidence 0.160914031182186 0.501383658457645 1.36997103634344 0.3125 11.1 11 1 large intestinal inflammation 0.160914031182186 0.501383658457645 1.36997103634344 0.3125 11.1 11 1 abnormal epididymis epithelium morphology 0.160914031182186 0.501383658457645 1.36997103634344 0.3125 11.1 11 1 abnormal level of surface class II molecules 0.160914031182186 0.501383658457645 1.36997103634344 0.3125 11.1 11 1 sepsis 0.160914031182186 0.501383658457645 1.36997103634344 0.3125 11.1 11 1 decreased circulating growth hormone level 0.160914031182186 0.501383658457645 1.36997103634344 0.3125 11.1 11 1 blepharitis 0.160914031182186 0.501383658457645 1.36997103634344 0.3125 11.1 11 1 abnormal intestinal lipid absorption 0.160914031182186 0.501383658457645 1.36997103634344 0.3125 11.1 11 1 decreased creatinine clearance 0.160914031182186 0.501383658457645 1.36997103634344 0.3125 11.1 11 1 impaired behavioral response to addictive substance 0.160914031182186 0.501383658457645 1.36997103634344 0.3125 11.1 11 1 decreased liver cholesterol level 0.160914031182186 0.501383658457645 1.36997103634344 0.3125 11.1 11 1 decreased skeletal muscle weight 0.160914031182186 0.501383658457645 1.36997103634344 0.3125 11.1 11 1 extramedullary hematopoiesis 0.00126054655612109 0.0250848764668098 1.3648013343195 0.311320754716981 11.1 11 1 abnormal cell migration 0.0296982479755192 0.221512419307658 1.36388227618191 0.311111111111111 11.1 11 1 cardiomyopathy 0.0296982479755192 0.221512419307658 1.36388227618191 0.311111111111111 11.1 11 1 postnatal growth retardation 4.6936647861621e-14 2.91887278889455e-11 1.36101697728237 0.310457516339869 11.1 11 1 dermatitis 0.015315314896396 0.139548885731814 1.36052296023072 0.310344827586207 11.1 11 1 thrombocytosis 0.015315314896396 0.139548885731814 1.36052296023072 0.310344827586207 11.1 11 1 abnormal microglial cell morphology 0.0743985370337196 0.37236692328245 1.36052296023072 0.310344827586207 11.1 11 1 aphagia 0.0743985370337196 0.37236692328245 1.36052296023072 0.310344827586207 11.1 11 1 decreased heart rate 0.00187467608087716 0.0336697238352486 1.35901126805269 0.31 11.1 11 1 perinatal lethality, complete penetrance 8.38234059467924e-06 0.000508562737299137 1.358393816318 0.309859154929577 11.1 11 1 disheveled coat 0.0368555587274084 0.237508296203182 1.35692369314017 0.30952380952381 11.1 11 1 increased heart weight 0.00029935169526399 0.00860852418461474 1.35617276691264 0.309352517985612 11.1 11 1 increased sensitivity to xenobiotic induced morbidity/mortality 0.00123330195123593 0.0247753280022129 1.35502589776515 0.309090909090909 11.1 11 1 decreased circulating calcium level 0.0188768972985018 0.16418280430078 1.35502589776515 0.309090909090909 11.1 11 1 abnormal head morphology 0.0188768972985018 0.16418280430078 1.35502589776515 0.309090909090909 11.1 11 1 abnormal embryo turning 0.0188768972985018 0.16418280430078 1.35502589776515 0.309090909090909 11.1 11 1 infertility 0.00150241928548574 0.0283126361564075 1.35204618166231 0.308411214953271 11.1 11 1 decreased bone mineral density 9.26117631352996e-07 9.03418669800226e-05 1.35143007494932 0.308270676691729 11.1 11 1 abnormal cardiovascular system physiology 0.00044196325866389 0.0115724590097519 1.35143007494932 0.308270676691729 11.1 11 1 preweaning lethality, incomplete penetrance 1.40086627735785e-09 3.31871891897873e-07 1.35054357421436 0.308068459657702 11.1 11 1 increased insulin sensitivity 0.000292663187701684 0.0084651125512551 1.34889455886123 0.307692307692308 11.1 11 1 absent corpus luteum 0.0232933890471514 0.187515550986373 1.34889455886123 0.307692307692308 11.1 11 1 abnormal skin condition 0.0232933890471514 0.187515550986373 1.34889455886123 0.307692307692308 11.1 11 1 abnormal ureter morphology 0.0938184131454805 0.404109615063866 1.34889455886123 0.307692307692308 11.1 11 1 small seminal vesicle 0.0938184131454805 0.404109615063866 1.34889455886123 0.307692307692308 11.1 11 1 no spontaneous movement 0.0938184131454805 0.404109615063866 1.34889455886123 0.307692307692308 11.1 11 1 heart inflammation 0.0938184131454805 0.404109615063866 1.34889455886123 0.307692307692308 11.1 11 1 small liver 0.00639076032545585 0.0773454462955294 1.34889455886123 0.307692307692308 11.1 11 1 abnormal cornea morphology 0.00639076032545585 0.0773454462955294 1.34889455886123 0.307692307692308 11.1 11 1 abnormal suckling behavior 0.00416101400862268 0.0584775273810673 1.34506247204628 0.306818181818182 11.1 11 1 decreased leukocyte cell number 0.00043147604419317 0.0114791086623584 1.34397158601867 0.306569343065693 11.1 11 1 impaired glucose tolerance 2.89589598838601e-06 0.000221647423726467 1.34345546789808 0.306451612903226 11.1 11 1 increased eosinophil cell number 0.0148833170405372 0.137885479099949 1.34345546789808 0.306451612903226 11.1 11 1 respiratory distress 8.5584684504166e-05 0.00335262838904115 1.34304675008004 0.30635838150289 11.1 11 1 decreased circulating cholesterol level 5.69159954239706e-05 0.00237947123726264 1.34152355034286 0.306010928961749 11.1 11 1 heart right ventricle hypertrophy 0.0571203073868994 0.309894797437104 1.33952723553581 0.305555555555556 11.1 11 1 abnormal pharyngeal arch morphology 0.0571203073868994 0.309894797437104 1.33952723553581 0.305555555555556 11.1 11 1 narrow eye opening 0.0571203073868994 0.309894797437104 1.33952723553581 0.305555555555556 11.1 11 1 decreased birth weight 0.00331643805824739 0.049696624517412 1.33824539129127 0.305263157894737 11.1 11 1 abnormal colon morphology 0.018305486894159 0.160900701940708 1.33746324904037 0.305084745762712 11.1 11 1 abnormal sternum morphology 0.0117503277965676 0.119790739319516 1.3342326614823 0.304347826086957 11.1 11 1 abnormal myelin sheath morphology 0.0356085974689159 0.231134396691897 1.3342326614823 0.304347826086957 11.1 11 1 abnormal blood vessel physiology 0.118911076717264 0.471005260086298 1.3342326614823 0.304347826086957 11.1 11 1 hypotension 0.118911076717264 0.471005260086298 1.3342326614823 0.304347826086957 11.1 11 1 failure of embryo implantation 0.118911076717264 0.471005260086298 1.3342326614823 0.304347826086957 11.1 11 1 abnormal postnatal growth 0.118911076717264 0.471005260086298 1.3342326614823 0.304347826086957 11.1 11 1 abnormal cochlear ganglion morphology 0.118911076717264 0.471005260086298 1.3342326614823 0.304347826086957 11.1 11 1 dilated heart 0.118911076717264 0.471005260086298 1.3342326614823 0.304347826086957 11.1 11 1 abnormal ulna morphology 0.118911076717264 0.471005260086298 1.3342326614823 0.304347826086957 11.1 11 1 abnormal chondrocyte physiology 0.118911076717264 0.471005260086298 1.3342326614823 0.304347826086957 11.1 11 1 abnormal palatal shelf fusion at midline 0.118911076717264 0.471005260086298 1.3342326614823 0.304347826086957 11.1 11 1 abnormal basicranium morphology 0.118911076717264 0.471005260086298 1.3342326614823 0.304347826086957 11.1 11 1 postnatal lethality, complete penetrance 1.47281682531541e-08 2.36363345353037e-06 1.32880092229788 0.303108808290155 11.1 11 1 belly spot 0.071382820509745 0.359807023339394 1.32845676251485 0.303030303030303 11.1 11 1 abnormal kidney morphology 0.000119091001338449 0.00426242972416391 1.32769764436484 0.302857142857143 11.1 11 1 preweaning lethality, complete penetrance 5.40846627436092e-15 3.84387424499223e-12 1.32702059304186 0.302702702702703 11.1 11 1 abnormal lung morphology 0.00138508179821056 0.0268123811132201 1.32622406207365 0.302521008403361 11.1 11 1 edema 0.000144123877020152 0.00508522190195218 1.32536732818342 0.302325581395349 11.1 11 1 abnormal placenta development 0.0277706023038263 0.20933143403263 1.323443718128 0.30188679245283 11.1 11 1 decreased grip strength 2.26371271442754e-05 0.00116102791281206 1.32117754737778 0.301369863013699 11.1 11 1 abnormal seminiferous tubule morphology 0.000481708218796252 0.0123127561861145 1.32117754737778 0.301369863013699 11.1 11 1 postnatal lethality, incomplete penetrance 1.44482144761511e-11 6.53453336535017e-09 1.31980308289987 0.301056338028169 11.1 11 1 abnormal embryo size 0.0020444945855485 0.035439704733037 1.31905175888642 0.300884955752212 11.1 11 1 female infertility 3.60089388883467e-06 0.000263447751425772 1.31846836580421 0.300751879699248 11.1 11 1 abnormal retinal pigment epithelium morphology 0.00897788910756294 0.0968871980696868 1.3151721948897 0.3 11.1 11 1 abnormal basioccipital bone morphology 0.151681941206622 0.501383658457645 1.3151721948897 0.3 11.1 11 1 abnormal dopamine level 0.151681941206622 0.501383658457645 1.3151721948897 0.3 11.1 11 1 abnormal fibula morphology 0.151681941206622 0.501383658457645 1.3151721948897 0.3 11.1 11 1 abnormal trachea morphology 0.151681941206622 0.501383658457645 1.3151721948897 0.3 11.1 11 1 abnormal lens epithelium morphology 0.151681941206622 0.501383658457645 1.3151721948897 0.3 11.1 11 1 increased skin tumor incidence 0.151681941206622 0.501383658457645 1.3151721948897 0.3 11.1 11 1 abnormal heart electrocardiography waveform feature 0.151681941206622 0.501383658457645 1.3151721948897 0.3 11.1 11 1 thick epidermis 0.0139150489692811 0.132113298897278 1.3151721948897 0.3 11.1 11 1 decreased circulating alkaline phosphatase level 0.0342602246142212 0.226996944682918 1.3151721948897 0.3 11.1 11 1 increased circulating chloride level 0.0342602246142212 0.226996944682918 1.3151721948897 0.3 11.1 11 1 abnormal axon extension 0.0342602246142212 0.226996944682918 1.3151721948897 0.3 11.1 11 1 abnormal estrous cycle 0.0894861789951772 0.392599149515529 1.3151721948897 0.3 11.1 11 1 emphysema 0.0894861789951772 0.392599149515529 1.3151721948897 0.3 11.1 11 1 abnormal synaptic transmission 0.0894861789951772 0.392599149515529 1.3151721948897 0.3 11.1 11 1 decreased erythrocyte cell number 0.000373869139495918 0.0103910556926938 1.31237989723601 0.299363057324841 11.1 11 1 double outlet right ventricle 0.00301883050444794 0.0468792281415076 1.3110750852483 0.299065420560748 11.1 11 1 abnormal spermatogenesis 0.000131590898574533 0.00467617657434502 1.31040707824155 0.298913043478261 11.1 11 1 abnormal craniofacial bone morphology 0.0267067846387242 0.203159409140142 1.30748112942251 0.298245614035088 11.1 11 1 decreased brain weight 0.0267067846387242 0.203159409140142 1.30748112942251 0.298245614035088 11.1 11 1 increased white adipose tissue amount 0.0681499947192669 0.344559170455643 1.30332379673754 0.297297297297297 11.1 11 1 decreased caudal vertebrae number 0.020888355752842 0.177738448091667 1.30147248452627 0.296875 11.1 11 1 abnormal neural tube morphology 0.000422780426292914 0.011369365517877 1.29893550112563 0.296296296296296 11.1 11 1 abnormal maxilla morphology 0.0328564197471194 0.226996944682918 1.29893550112563 0.296296296296296 11.1 11 1 abnormal osteoblast physiology 0.0328564197471194 0.226996944682918 1.29893550112563 0.296296296296296 11.1 11 1 abnormal trigeminal nerve morphology 0.11259861129302 0.452121138969148 1.29893550112563 0.296296296296296 11.1 11 1 abnormal trigeminal ganglion morphology 0.11259861129302 0.452121138969148 1.29893550112563 0.296296296296296 11.1 11 1 wrinkled skin 0.11259861129302 0.452121138969148 1.29893550112563 0.296296296296296 11.1 11 1 thin epidermis 0.11259861129302 0.452121138969148 1.29893550112563 0.296296296296296 11.1 11 1 embryonic lethality before implantation, complete penetrance 0.00184529037332942 0.0333829803902322 1.2976365656245 0.296 11.1 11 1 hypertension 0.052343057756326 0.288699237624969 1.29524534345198 0.295454545454545 11.1 11 1 omphalocele 0.052343057756326 0.288699237624969 1.29524534345198 0.295454545454545 11.1 11 1 decreased sensitivity to induced morbidity/mortality 0.052343057756326 0.288699237624969 1.29524534345198 0.295454545454545 11.1 11 1 increased embryonic tissue cell apoptosis 0.0128808657223214 0.124856389321554 1.29269061890868 0.294871794871795 11.1 11 1 abnormal coat/hair pigmentation 0.00340887081085195 0.0504736079880609 1.29168697712381 0.294642857142857 11.1 11 1 abnormal direction of heart looping 0.0849757390703132 0.392599149515529 1.28938450479382 0.294117647058824 11.1 11 1 increased aggression towards mice 0.195093327040866 0.522383908519003 1.28938450479382 0.294117647058824 11.1 11 1 abnormal dorsal-ventral axis patterning 0.195093327040866 0.522383908519003 1.28938450479382 0.294117647058824 11.1 11 1 pancytopenia 0.195093327040866 0.522383908519003 1.28938450479382 0.294117647058824 11.1 11 1 coloboma 0.195093327040866 0.522383908519003 1.28938450479382 0.294117647058824 11.1 11 1 delayed heart development 0.195093327040866 0.522383908519003 1.28938450479382 0.294117647058824 11.1 11 1 abnormal neurocranium morphology 0.0157169123584993 0.14139536886715 1.28594614611437 0.293333333333333 11.1 11 1 abnormal limb morphology 0.0157169123584993 0.14139536886715 1.28594614611437 0.293333333333333 11.1 11 1 abnormal mammary gland development 0.0648408298115023 0.337980055278605 1.28309482428263 0.292682926829268 11.1 11 1 thick ventricular wall 0.0648408298115023 0.337980055278605 1.28309482428263 0.292682926829268 11.1 11 1 increased tumor growth/size 0.0648408298115023 0.337980055278605 1.28309482428263 0.292682926829268 11.1 11 1 hemopericardium 0.0648408298115023 0.337980055278605 1.28309482428263 0.292682926829268 11.1 11 1 ataxia 0.000155013546847217 0.00528213969565003 1.28044817654278 0.292079207920792 11.1 11 1 abnormal heart left ventricle morphology 0.0191824209902604 0.166548943152785 1.27863963392054 0.291666666666667 11.1 11 1 vertebral transformation 0.049872274373291 0.276296842992341 1.27863963392054 0.291666666666667 11.1 11 1 hemolytic anemia 0.142317896139816 0.501383658457645 1.27863963392054 0.291666666666667 11.1 11 1 abnormal retinal ganglion layer morphology 0.142317896139816 0.501383658457645 1.27863963392054 0.291666666666667 11.1 11 1 hypopigmentation 0.142317896139816 0.501383658457645 1.27863963392054 0.291666666666667 11.1 11 1 increased body temperature 0.142317896139816 0.501383658457645 1.27863963392054 0.291666666666667 11.1 11 1 abnormal cellular extravasation 0.142317896139816 0.501383658457645 1.27863963392054 0.291666666666667 11.1 11 1 abnormal truncus arteriosus septation 0.142317896139816 0.501383658457645 1.27863963392054 0.291666666666667 11.1 11 1 abnormal behavior 1.16901195762871e-05 0.000678910994619831 1.27732551302237 0.29136690647482 11.1 11 1 abnormal craniofacial morphology 0.00607578477025447 0.0761386126751032 1.27686620863078 0.29126213592233 11.1 11 1 limb grasping 0.000351373920481646 0.00987618787794457 1.27663235035081 0.291208791208791 11.1 11 1 abnormal heart development 0.00083255876432878 0.0186613225161065 1.27632744651743 0.291139240506329 11.1 11 1 abnormal rostral-caudal axis patterning 0.0385916084439882 0.242224030608906 1.27531849201425 0.290909090909091 11.1 11 1 decreased startle reflex 0.00381216290832583 0.0543424368736992 1.27395597225783 0.290598290598291 11.1 11 1 increased tumor incidence 0.00302477029817567 0.0468792281415076 1.27274728537713 0.290322580645161 11.1 11 1 abnormal definitive hematopoiesis 0.00933005399989563 0.100279425767235 1.27274728537713 0.290322580645161 11.1 11 1 abnormal eyelid morphology 0.106240918105082 0.430063928049457 1.27274728537713 0.290322580645161 11.1 11 1 abnormal object recognition memory 0.106240918105082 0.430063928049457 1.27274728537713 0.290322580645161 11.1 11 1 abnormal nose morphology 0.106240918105082 0.430063928049457 1.27274728537713 0.290322580645161 11.1 11 1 decreased susceptibility to bacterial infection induced morbidity/mortality 0.106240918105082 0.430063928049457 1.27274728537713 0.290322580645161 11.1 11 1 embryonic lethality between implantation and somite formation, complete penetrance 4.71624622056052e-05 0.00205818639888496 1.2704384467642 0.289795918367347 11.1 11 1 increased circulating triglyceride level 0.00151926429645676 0.0284148115596706 1.26982142954868 0.289655172413793 11.1 11 1 thrombocytopenia 0.00151926429645676 0.0284148115596706 1.26982142954868 0.289655172413793 11.1 11 1 seizures 0.00461127054274501 0.061013486569565 1.26902580208655 0.289473684210526 11.1 11 1 abnormal frontal bone morphology 0.0804591970994216 0.385094648079626 1.26902580208655 0.289473684210526 11.1 11 1 incomplete somite formation 0.0804591970994216 0.385094648079626 1.26902580208655 0.289473684210526 11.1 11 1 abnormal autopod morphology 0.0615425117297786 0.326059208631231 1.26646211359749 0.288888888888889 11.1 11 1 abnormal brain wave pattern 0.0474187736208218 0.269314543492621 1.2645886489324 0.288461538461538 11.1 11 1 increased susceptibility to injury 0.0474187736208218 0.269314543492621 1.2645886489324 0.288461538461538 11.1 11 1 increased percent body fat/body weight 0.0474187736208218 0.269314543492621 1.2645886489324 0.288461538461538 11.1 11 1 syndactyly 0.0367424110495933 0.237394149313931 1.2631597352048 0.288135593220339 11.1 11 1 increased sensitivity to induced morbidity/mortality 0.000469095809040995 0.012154956510307 1.26275591176004 0.28804347826087 11.1 11 1 abnormal tail morphology 0.028597304880937 0.215236901335342 1.26203392438911 0.287878787878788 11.1 11 1 lung inflammation 0.00266110219248375 0.0418955171126794 1.25714989217398 0.286764705882353 11.1 11 1 hypoactivity 1.12279227157497e-06 0.000103442436131213 1.25586734790528 0.286472148541114 11.1 11 1 cyanosis 0.000431218092805514 0.0114791086623584 1.25580678331482 0.286458333333333 11.1 11 1 increased fluid intake 0.0583093017266164 0.316000845413852 1.252544947514 0.285714285714286 11.1 11 1 abnormal B cell differentiation 0.0131183482338429 0.125991858037391 1.252544947514 0.285714285714286 11.1 11 1 impaired fertilization 0.02721962312355 0.205489567586739 1.252544947514 0.285714285714286 11.1 11 1 domed cranium 0.02721962312355 0.205489567586739 1.252544947514 0.285714285714286 11.1 11 1 abnormal action potential 0.02721962312355 0.205489567586739 1.252544947514 0.285714285714286 11.1 11 1 decreased susceptibility to hepatic steatosis 0.0349310428838288 0.229263770906396 1.252544947514 0.285714285714286 11.1 11 1 increased circulating aspartate transaminase level 0.0349310428838288 0.229263770906396 1.252544947514 0.285714285714286 11.1 11 1 decreased circulating thyroxine level 0.100030483972061 0.411877342812783 1.252544947514 0.285714285714286 11.1 11 1 increased red blood cell distribution width 0.100030483972061 0.411877342812783 1.252544947514 0.285714285714286 11.1 11 1 small ears 0.180877635652135 0.501383658457645 1.252544947514 0.285714285714286 11.1 11 1 abnormal scapula morphology 0.180877635652135 0.501383658457645 1.252544947514 0.285714285714286 11.1 11 1 abnormal erythrocyte physiology 0.180877635652135 0.501383658457645 1.252544947514 0.285714285714286 11.1 11 1 embryonic lethality at implantation, complete penetrance 0.180877635652135 0.501383658457645 1.252544947514 0.285714285714286 11.1 11 1 short mandible 0.0450141256985524 0.266919279320975 1.252544947514 0.285714285714286 11.1 11 1 rib bifurcation 0.133245028263469 0.492126217973838 1.252544947514 0.285714285714286 11.1 11 1 abnormal circulating cholesterol level 0.133245028263469 0.492126217973838 1.252544947514 0.285714285714286 11.1 11 1 abnormal jaw morphology 0.133245028263469 0.492126217973838 1.252544947514 0.285714285714286 11.1 11 1 lymphoid hyperplasia 0.133245028263469 0.492126217973838 1.252544947514 0.285714285714286 11.1 11 1 increased bone resorption 0.133245028263469 0.492126217973838 1.252544947514 0.285714285714286 11.1 11 1 hypoxia 0.133245028263469 0.492126217973838 1.252544947514 0.285714285714286 11.1 11 1 corneal vascularization 0.133245028263469 0.492126217973838 1.252544947514 0.285714285714286 11.1 11 1 prolonged QRS complex duration 0.133245028263469 0.492126217973838 1.252544947514 0.285714285714286 11.1 11 1 respiratory failure 0.00193526263284477 0.0345087154064614 1.24839744768779 0.28476821192053 11.1 11 1 enlarged spleen 2.60531202760221e-05 0.00129586467435056 1.24819583311291 0.284722222222222 11.1 11 1 abnormal vertebrae morphology 0.00778175650256837 0.086998288989388 1.24679932848871 0.284403669724771 11.1 11 1 increased bone mineral content 0.00778175650256837 0.086998288989388 1.24679932848871 0.284403669724771 11.1 11 1 alopecia 0.0125052636819203 0.124841244496398 1.24595260568498 0.284210526315789 11.1 11 1 increased liver weight 0.0158975944860924 0.142249159295521 1.24542821485767 0.284090909090909 11.1 11 1 decreased compact bone thickness 0.0331704346630238 0.226996944682918 1.24319759715942 0.283582089552239 11.1 11 1 impaired coordination 5.81048295245363e-06 0.000385428702512757 1.24168473120608 0.283236994219653 11.1 11 1 increased spleen weight 0.00742124227538325 0.085069099305264 1.24146047895193 0.283185840707965 11.1 11 1 abnormal forelimb morphology 0.0717589021961791 0.361336577354242 1.23893032851928 0.282608695652174 11.1 11 1 decreased neutrophil cell number 0.00707284349743132 0.0835805140135886 1.23648667895613 0.282051282051282 11.1 11 1 abnormal skeletal muscle fiber morphology 0.0314690937240137 0.226996944682918 1.23490346938 0.28169014084507 11.1 11 1 abnormal rib morphology 0.00423009879003331 0.0592319450299015 1.23398872606935 0.281481481481481 11.1 11 1 abnormal crypts of Lieberkuhn morphology 0.124631113052797 0.477204559173318 1.23297393270909 0.28125 11.1 11 1 bradykinesia 0.124631113052797 0.477204559173318 1.23297393270909 0.28125 11.1 11 1 abnormal serotonin level 0.124631113052797 0.477204559173318 1.23297393270909 0.28125 11.1 11 1 pancreatic islet hyperplasia 0.124631113052797 0.477204559173318 1.23297393270909 0.28125 11.1 11 1 retinal degeneration 0.0143912165319341 0.133575190758157 1.23297393270909 0.28125 11.1 11 1 neonatal lethality, complete penetrance 4.11391419285821e-07 4.26390064780616e-05 1.2305704747506 0.280701754385965 11.1 11 1 short stride length 0.0676617206036586 0.343905917823144 1.22749404856372 0.28 11.1 11 1 abnormal digestive system physiology 0.0676617206036586 0.343905917823144 1.22749404856372 0.28 11.1 11 1 abnormal circulating protein level 0.0676617206036586 0.343905917823144 1.22749404856372 0.28 11.1 11 1 decreased respiratory quotient 0.0676617206036586 0.343905917823144 1.22749404856372 0.28 11.1 11 1 ruffled hair 0.167732592579499 0.501383658457645 1.22749404856372 0.28 11.1 11 1 abnormal egg cylinder morphology 0.167732592579499 0.501383658457645 1.22749404856372 0.28 11.1 11 1 abnormal cochlear outer hair cell morphology 0.167732592579499 0.501383658457645 1.22749404856372 0.28 11.1 11 1 abnormal energy expenditure 0.167732592579499 0.501383658457645 1.22749404856372 0.28 11.1 11 1 increased liver glycogen level 0.167732592579499 0.501383658457645 1.22749404856372 0.28 11.1 11 1 decreased circulating alanine transaminase level 0.0382632660376287 0.240961707009117 1.22491527955413 0.279411764705882 11.1 11 1 abnormal male reproductive system morphology 0.0883860766632865 0.392599149515529 1.22341599524623 0.27906976744186 11.1 11 1 abnormal left-right axis patterning 0.0883860766632865 0.392599149515529 1.22341599524623 0.27906976744186 11.1 11 1 abnormal mandible morphology 0.0637585580167576 0.334245338391327 1.21775203230528 0.277777777777778 11.1 11 1 abnormal cell adhesion 0.0637585580167576 0.334245338391327 1.21775203230528 0.277777777777778 11.1 11 1 renal hypoplasia 0.116534398043278 0.465471789347705 1.21775203230528 0.277777777777778 11.1 11 1 abnormal lysosome morphology 0.116534398043278 0.465471789347705 1.21775203230528 0.277777777777778 11.1 11 1 abnormal megakaryocyte differentiation 0.231489980205786 0.581853286315772 1.21775203230528 0.277777777777778 11.1 11 1 abnormal heart shape 0.231489980205786 0.581853286315772 1.21775203230528 0.277777777777778 11.1 11 1 delayed kidney development 0.231489980205786 0.581853286315772 1.21775203230528 0.277777777777778 11.1 11 1 abnormal radius morphology 0.231489980205786 0.581853286315772 1.21775203230528 0.277777777777778 11.1 11 1 abnormal retinal rod cell morphology 0.231489980205786 0.581853286315772 1.21775203230528 0.277777777777778 11.1 11 1 absent ureter 0.231489980205786 0.581853286315772 1.21775203230528 0.277777777777778 11.1 11 1 long tibia 0.231489980205786 0.581853286315772 1.21775203230528 0.277777777777778 11.1 11 1 abnormal anterior eye segment morphology 0.231489980205786 0.581853286315772 1.21775203230528 0.277777777777778 11.1 11 1 abnormal glycogen homeostasis 0.231489980205786 0.581853286315772 1.21775203230528 0.277777777777778 11.1 11 1 increased gastrointestinal tumor incidence 0.231489980205786 0.581853286315772 1.21775203230528 0.277777777777778 11.1 11 1 atrioventricular block 0.231489980205786 0.581853286315772 1.21775203230528 0.277777777777778 11.1 11 1 primary atelectasis 0.231489980205786 0.581853286315772 1.21775203230528 0.277777777777778 11.1 11 1 cleft secondary palate 0.0198899447948662 0.171198054246469 1.21257010876355 0.276595744680851 11.1 11 1 male infertility 3.59203139871466e-07 3.884860045349e-05 1.21145748899714 0.276341948310139 11.1 11 1 cochlear ganglion degeneration 0.0600549784679224 0.32123677471404 1.20935374242731 0.275862068965517 11.1 11 1 stomach inflammation 0.155662739208136 0.501383658457645 1.20935374242731 0.275862068965517 11.1 11 1 short sternum 0.155662739208136 0.501383658457645 1.20935374242731 0.275862068965517 11.1 11 1 decreased circulating phosphate level 0.108963127231752 0.439652520663395 1.20557451198222 0.275 11.1 11 1 perinatal lethality 0.108963127231752 0.439652520663395 1.20557451198222 0.275 11.1 11 1 abnormal response to novel object 0.0779544421026066 0.383248547440171 1.20342553780757 0.274509803921569 11.1 11 1 abnormal thrombosis 0.0779544421026066 0.383248547440171 1.20342553780757 0.274509803921569 11.1 11 1 increased bone mineral density 0.0133345237474949 0.127821301818472 1.20266483898468 0.274336283185841 11.1 11 1 increased food intake 0.0305612461738173 0.226590461571894 1.20035557470092 0.273809523809524 11.1 11 1 reduced fertility 0.0071249449159781 0.0839966847322063 1.1984782591321 0.273381294964029 11.1 11 1 no abnormal phenotype detected 3.10520292354817e-20 5.14946151488405e-17 1.19767842531742 0.273198847262248 11.1 11 1 abnormal skeleton physiology 0.144599222756442 0.501383658457645 1.19561108626336 0.272727272727273 11.1 11 1 increased osteoblast cell number 0.144599222756442 0.501383658457645 1.19561108626336 0.272727272727273 11.1 11 1 diarrhea 0.144599222756442 0.501383658457645 1.19561108626336 0.272727272727273 11.1 11 1 abnormal motor coordination/ balance 0.0214414856497843 0.178399593949701 1.19561108626336 0.272727272727273 11.1 11 1 hyperglycemia 0.0288694584818475 0.21630354811324 1.19561108626336 0.272727272727273 11.1 11 1 abnormal myelopoiesis 0.101902208753397 0.414524520480907 1.19561108626336 0.272727272727273 11.1 11 1 cochlear hair cell degeneration 0.101902208753397 0.414524520480907 1.19561108626336 0.272727272727273 11.1 11 1 testis hypoplasia 0.212081971141042 0.560035990672338 1.19561108626336 0.272727272727273 11.1 11 1 increased coping response 0.212081971141042 0.560035990672338 1.19561108626336 0.272727272727273 11.1 11 1 abnormal lysosome physiology 0.212081971141042 0.560035990672338 1.19561108626336 0.272727272727273 11.1 11 1 abnormal retinal layer morphology 0.212081971141042 0.560035990672338 1.19561108626336 0.272727272727273 11.1 11 1 rough coat 0.212081971141042 0.560035990672338 1.19561108626336 0.272727272727273 11.1 11 1 abnormal skeleton development 0.0368520480635182 0.237508296203182 1.19069087603183 0.271604938271605 11.1 11 1 abnormal intestinal epithelium morphology 0.0953259541794689 0.408309848641354 1.18730823149765 0.270833333333333 11.1 11 1 curly tail 0.0953259541794689 0.408309848641354 1.18730823149765 0.270833333333333 11.1 11 1 thymus atrophy 0.0953259541794689 0.408309848641354 1.18730823149765 0.270833333333333 11.1 11 1 abnormal angiogenesis 0.0471801275855315 0.269314543492621 1.18483981521595 0.27027027027027 11.1 11 1 small seminiferous tubules 0.0471801275855315 0.269314543492621 1.18483981521595 0.27027027027027 11.1 11 1 abnormal branching of the mammary ductal tree 0.134454547422541 0.494756933008239 1.18483981521595 0.27027027027027 11.1 11 1 decreased width of hypertrophic chondrocyte zone 0.134454547422541 0.494756933008239 1.18483981521595 0.27027027027027 11.1 11 1 abnormal spleen morphology 0.00390471860481693 0.0555027858827549 1.18415887279341 0.270114942528736 11.1 11 1 increased or absent threshold for auditory brainstem response 0.000267621745027061 0.00792510822327161 1.18319989851669 0.269896193771626 11.1 11 1 abnormal hair follicle morphology 0.0645403671890421 0.337980055278605 1.18295911709656 0.26984126984127 11.1 11 1 decreased total body fat amount 0.000101901572822073 0.00378328600589411 1.18129239061949 0.269461077844311 11.1 11 1 thick skin 0.19496413237098 0.522383908519003 1.18028273900358 0.269230769230769 11.1 11 1 increased susceptibility to otitis media 0.19496413237098 0.522383908519003 1.18028273900358 0.269230769230769 11.1 11 1 abnormal heart ventricle morphology 0.0444123452144199 0.263665175944796 1.18028273900358 0.269230769230769 11.1 11 1 increased circulating insulin level 0.00614460888297003 0.0768076110371254 1.17817509125536 0.26875 11.1 11 1 rib fusion 0.0606140112745146 0.323209760011479 1.17776614467734 0.26865671641791 11.1 11 1 sparse hair 0.0418081027478813 0.25741993956771 1.17617025559241 0.268292682926829 11.1 11 1 short humerus 0.12514130295251 0.478170493232519 1.17617025559241 0.268292682926829 11.1 11 1 abnormal CD4-positive, alpha-beta T cell physiology 0.0569350607149129 0.309894797437104 1.173158295911 0.267605633802817 11.1 11 1 abnormal eye physiology 0.0782023482568232 0.383248547440171 1.16904195101307 0.266666666666667 11.1 11 1 altered response to myocardial infarction 0.116578462216531 0.465471789347705 1.16904195101307 0.266666666666667 11.1 11 1 irregular heartbeat 0.116578462216531 0.465471789347705 1.16904195101307 0.266666666666667 11.1 11 1 abnormal ectoderm development 0.116578462216531 0.465471789347705 1.16904195101307 0.266666666666667 11.1 11 1 delayed eyelid opening 0.179726942921939 0.501383658457645 1.16904195101307 0.266666666666667 11.1 11 1 abnormal fat pad morphology 0.179726942921939 0.501383658457645 1.16904195101307 0.266666666666667 11.1 11 1 increased anxiety-related response 0.0121889034186321 0.122451788810497 1.16693935757599 0.266187050359712 11.1 11 1 decreased B cell proliferation 0.0502594614353352 0.278132169789536 1.16534245116809 0.265822784810127 11.1 11 1 abnormal osteoclast physiology 0.0732625824270603 0.367791470811932 1.16447538089192 0.265625 11.1 11 1 increased circulating LDL cholesterol level 0.108693078676332 0.439275439817021 1.163077451263 0.26530612244898 11.1 11 1 increased sarcoma incidence 0.108693078676332 0.439275439817021 1.163077451263 0.26530612244898 11.1 11 1 abnormal retinal photoreceptor morphology 0.166063676883448 0.501383658457645 1.16044605431444 0.264705882352941 11.1 11 1 abnormal bone remodeling 0.166063676883448 0.501383658457645 1.16044605431444 0.264705882352941 11.1 11 1 abnormal nervous system development 0.166063676883448 0.501383658457645 1.16044605431444 0.264705882352941 11.1 11 1 small testis 0.000766829020484261 0.0178269830696692 1.15951171771676 0.264492753623188 11.1 11 1 decreased bone mineral content 0.00317704740390096 0.0486332641058685 1.15920626152137 0.264423076923077 11.1 11 1 small ovary 0.0417428439011309 0.25733661512779 1.15619533616677 0.263736263736264 11.1 11 1 increased thermal nociceptive threshold 0.0417428439011309 0.25733661512779 1.15619533616677 0.263736263736264 11.1 11 1 abnormal reproductive system physiology 0.153738601109369 0.501383658457645 1.15365982007868 0.263157894736842 11.1 11 1 hyporesponsive to tactile stimuli 0.153738601109369 0.501383658457645 1.15365982007868 0.263157894736842 11.1 11 1 flaky skin 0.269596191263883 0.654902857196201 1.15365982007868 0.263157894736842 11.1 11 1 unresponsive to tactile stimuli 0.269596191263883 0.654902857196201 1.15365982007868 0.263157894736842 11.1 11 1 abnormal long term depression 0.269596191263883 0.654902857196201 1.15365982007868 0.263157894736842 11.1 11 1 abnormal neurotransmitter level 0.269596191263883 0.654902857196201 1.15365982007868 0.263157894736842 11.1 11 1 abnormal nasal septum morphology 0.269596191263883 0.654902857196201 1.15365982007868 0.263157894736842 11.1 11 1 abnormal response to novelty 0.269596191263883 0.654902857196201 1.15365982007868 0.263157894736842 11.1 11 1 abnormal digestive system development 0.269596191263883 0.654902857196201 1.15365982007868 0.263157894736842 11.1 11 1 maternal imprinting 0.269596191263883 0.654902857196201 1.15365982007868 0.263157894736842 11.1 11 1 abnormal sternebra morphology 0.269596191263883 0.654902857196201 1.15365982007868 0.263157894736842 11.1 11 1 Leydig cell hypoplasia 0.269596191263883 0.654902857196201 1.15365982007868 0.263157894736842 11.1 11 1 abnormal behavioral response to xenobiotic 0.269596191263883 0.654902857196201 1.15365982007868 0.263157894736842 11.1 11 1 decreased circulating serum albumin level 0.0369176447588554 0.237600624418248 1.15132919417954 0.262626262626263 11.1 11 1 abnormal optic nerve morphology 0.142566142042222 0.501383658457645 1.14816620188783 0.261904761904762 11.1 11 1 skin edema 0.142566142042222 0.501383658457645 1.14816620188783 0.261904761904762 11.1 11 1 abnormal dendritic cell physiology 0.0326739964258205 0.226996944682918 1.14719069959226 0.261682242990654 11.1 11 1 increased T cell proliferation 0.0326739964258205 0.226996944682918 1.14719069959226 0.261682242990654 11.1 11 1 increased circulating cholesterol level 0.00815621993309135 0.0899716056920831 1.14579395766906 0.261363636363636 11.1 11 1 abnormal nervous system physiology 0.028938220393383 0.216492701439218 1.14362799555626 0.260869565217391 11.1 11 1 abnormal corneal stroma morphology 0.244965816231787 0.607227172771869 1.14362799555626 0.260869565217391 11.1 11 1 abnormal lens development 0.244965816231787 0.607227172771869 1.14362799555626 0.260869565217391 11.1 11 1 abnormal hepatocyte physiology 0.244965816231787 0.607227172771869 1.14362799555626 0.260869565217391 11.1 11 1 decreased effector memory CD8-positive, alpha-beta T cell number 0.244965816231787 0.607227172771869 1.14362799555626 0.260869565217391 11.1 11 1 abnormal fertility/fecundity 0.0724441908649305 0.364050353083868 1.14101697273536 0.26027397260274 11.1 11 1 astrocytosis 0.0724441908649305 0.364050353083868 1.14101697273536 0.26027397260274 11.1 11 1 increased body length 0.123109501782947 0.477204559173318 1.13981590223774 0.26 11.1 11 1 obese 0.067841340976077 0.343905917823144 1.13867722501273 0.25974025974026 11.1 11 1 cachexia 0.038856258676589 0.242224030608906 1.13812978403916 0.259615384615385 11.1 11 1 abnormal small intestine morphology 0.114601840705025 0.459793675409274 1.13656856348493 0.259259259259259 11.1 11 1 abnormal skin appearance 0.223792064748267 0.58137911282064 1.13656856348493 0.259259259259259 11.1 11 1 thick interventricular septum 0.223792064748267 0.58137911282064 1.13656856348493 0.259259259259259 11.1 11 1 decreased rib number 0.0558623041157118 0.304397549809054 1.13291986825704 0.258426966292135 11.1 11 1 pericardial effusion 0.0995976785456428 0.411877342812783 1.13133092033523 0.258064516129032 11.1 11 1 autoimmune response 0.205287299379977 0.547616254378222 1.13133092033523 0.258064516129032 11.1 11 1 increased lung adenoma incidence 0.205287299379977 0.547616254378222 1.13133092033523 0.258064516129032 11.1 11 1 decreased lymphocyte cell number 0.0268938052440468 0.2039583553188 1.13022610498334 0.2578125 11.1 11 1 abnormal myocardial fiber morphology 0.0491711577757566 0.272961902632935 1.12987301966469 0.257731958762887 11.1 11 1 neonatal lethality, incomplete penetrance 0.00247493747395051 0.0401047320649845 1.12969919304628 0.257692307692308 11.1 11 1 abnormal skin morphology 0.0929660763788172 0.401829913105661 1.12918824813762 0.257575757575758 11.1 11 1 dehydration 0.0868398593605211 0.392599149515529 1.1272904527626 0.257142857142857 11.1 11 1 increased carcinoma incidence 0.188921320583543 0.508595005358835 1.1272904527626 0.257142857142857 11.1 11 1 holoprosencephaly 0.188921320583543 0.508595005358835 1.1272904527626 0.257142857142857 11.1 11 1 abnormal hippocampus pyramidal cell morphology 0.188921320583543 0.508595005358835 1.1272904527626 0.257142857142857 11.1 11 1 decreased bone volume 0.188921320583543 0.508595005358835 1.1272904527626 0.257142857142857 11.1 11 1 decreased B-1 B cell number 0.17431616801885 0.501383658457645 1.12407879905103 0.256410256410256 11.1 11 1 abnormal response to injury 0.17431616801885 0.501383658457645 1.12407879905103 0.256410256410256 11.1 11 1 abnormal circulating hormone level 0.17431616801885 0.501383658457645 1.12407879905103 0.256410256410256 11.1 11 1 abnormal response/metabolism to endogenous compounds 0.0710487477612926 0.358486328714433 1.1227079712473 0.25609756097561 11.1 11 1 abnormal double-strand DNA break repair 0.161190539516232 0.501383658457645 1.12146466230905 0.255813953488372 11.1 11 1 pulmonary hypoplasia 0.149327946879709 0.501383658457645 1.11929548501251 0.25531914893617 11.1 11 1 decreased T cell number 0.0184087401576679 0.161522896445146 1.11639875756683 0.254658385093168 11.1 11 1 decreased circulating total protein level 0.128740364421579 0.4866419251151 1.11590368051247 0.254545454545455 11.1 11 1 abnormal cranium morphology 0.0311237993984076 0.226996944682918 1.11233469219527 0.253731343283582 11.1 11 1 abnormal femur morphology 0.10396577851428 0.422228365802894 1.11233469219527 0.253731343283582 11.1 11 1 decreased food intake 0.0846188960814772 0.392599149515529 1.10984995349342 0.253164556962025 11.1 11 1 short tail 0.0791149528657782 0.383996966348533 1.10918136918408 0.253012048192771 11.1 11 1 increased inflammatory response 0.0648785834755915 0.337980055278605 1.10751342727554 0.252631578947368 11.1 11 1 abnormal uterus morphology 0.213050294763632 0.561401068034464 1.09597682907475 0.25 11.1 11 1 reduced long term depression 0.213050294763632 0.561401068034464 1.09597682907475 0.25 11.1 11 1 abnormal limb bone morphology 0.213050294763632 0.561401068034464 1.09597682907475 0.25 11.1 11 1 abnormal trophoblast giant cell morphology 0.213050294763632 0.561401068034464 1.09597682907475 0.25 11.1 11 1 short snout 0.0590655917965169 0.319325755539031 1.09597682907475 0.25 11.1 11 1 abnormal locomotor behavior 0.0767531288189578 0.37956939947745 1.09597682907475 0.25 11.1 11 1 arrest of spermatogenesis 0.0877697837661337 0.392599149515529 1.09597682907475 0.25 11.1 11 1 decreased exploration in new environment 0.0877697837661337 0.392599149515529 1.09597682907475 0.25 11.1 11 1 abnormal posture 0.0939465511421584 0.404311498211279 1.09597682907475 0.25 11.1 11 1 abnormal axial skeleton morphology 0.100629361151008 0.411877342812783 1.09597682907475 0.25 11.1 11 1 decreased susceptibility to injury 0.115734278165776 0.463962960414774 1.09597682907475 0.25 11.1 11 1 decreased eosinophil cell number 0.124288582406606 0.477204559173318 1.09597682907475 0.25 11.1 11 1 epidermal hyperplasia 0.133617308245511 0.492404524830679 1.09597682907475 0.25 11.1 11 1 abnormal eating behavior 0.133617308245511 0.492404524830679 1.09597682907475 0.25 11.1 11 1 abnormal long bone epiphyseal plate morphology 0.133617308245511 0.492404524830679 1.09597682907475 0.25 11.1 11 1 abnormal gametogenesis 0.180953316437176 0.501383658457645 1.09597682907475 0.25 11.1 11 1 abnormal hair shaft morphology 0.167328611113122 0.501383658457645 1.09597682907475 0.25 11.1 11 1 decreased body temperature 0.155008238734576 0.501383658457645 1.09597682907475 0.25 11.1 11 1 embryonic lethality, incomplete penetrance 0.180953316437176 0.501383658457645 1.09597682907475 0.25 11.1 11 1 abnormal pancreatic beta cell morphology 0.196100514947882 0.52479831192346 1.09597682907475 0.25 11.1 11 1 abnormal lymphatic vessel morphology 0.23217269482237 0.581853286315772 1.09597682907475 0.25 11.1 11 1 abnormal spongiotrophoblast layer morphology 0.23217269482237 0.581853286315772 1.09597682907475 0.25 11.1 11 1 abnormal malleus morphology 0.279181789595777 0.664260632949606 1.09597682907475 0.25 11.1 11 1 abnormal foregut morphology 0.279181789595777 0.664260632949606 1.09597682907475 0.25 11.1 11 1 decreased body height 0.279181789595777 0.664260632949606 1.09597682907475 0.25 11.1 11 1 abnormal startle reflex 0.279181789595777 0.664260632949606 1.09597682907475 0.25 11.1 11 1 abnormal vasodilation 0.279181789595777 0.664260632949606 1.09597682907475 0.25 11.1 11 1 abnormal sensory capabilities/reflexes/nociception 0.279181789595777 0.664260632949606 1.09597682907475 0.25 11.1 11 1 abnormal cardiac muscle contractility 0.279181789595777 0.664260632949606 1.09597682907475 0.25 11.1 11 1 abnormal osteoblast morphology 0.279181789595777 0.664260632949606 1.09597682907475 0.25 11.1 11 1 abnormal vascular regression 0.308900941282971 0.69247851090235 1.09597682907475 0.25 11.1 11 1 small gonad 0.308900941282971 0.69247851090235 1.09597682907475 0.25 11.1 11 1 abnormal circulating enzyme level 0.308900941282971 0.69247851090235 1.09597682907475 0.25 11.1 11 1 increased mammary adenocarcinoma incidence 0.308900941282971 0.69247851090235 1.09597682907475 0.25 11.1 11 1 anencephaly 0.308900941282971 0.69247851090235 1.09597682907475 0.25 11.1 11 1 decreased myocardial infarction size 0.308900941282971 0.69247851090235 1.09597682907475 0.25 11.1 11 1 abnormal hyoid bone morphology 0.308900941282971 0.69247851090235 1.09597682907475 0.25 11.1 11 1 abnormal heart right ventricle morphology 0.308900941282971 0.69247851090235 1.09597682907475 0.25 11.1 11 1 abnormal postnatal subventricular zone morphology 0.308900941282971 0.69247851090235 1.09597682907475 0.25 11.1 11 1 abnormal incus morphology 0.308900941282971 0.69247851090235 1.09597682907475 0.25 11.1 11 1 abnormal induced retinal neovascularization 0.308900941282971 0.69247851090235 1.09597682907475 0.25 11.1 11 1 nuclear cataracts 0.308900941282971 0.69247851090235 1.09597682907475 0.25 11.1 11 1 reduced long term potentiation 0.0553825465173233 0.302114220311056 1.09597682907475 0.25 11.1 11 1 abnormal ovulation 0.253974410243199 0.622731735317849 1.09597682907475 0.25 11.1 11 1 abnormal respiration 0.253974410243199 0.622731735317849 1.09597682907475 0.25 11.1 11 1 straub tail 0.253974410243199 0.622731735317849 1.09597682907475 0.25 11.1 11 1 abnormal hormone level 0.253974410243199 0.622731735317849 1.09597682907475 0.25 11.1 11 1 abnormal brainstem morphology 0.253974410243199 0.622731735317849 1.09597682907475 0.25 11.1 11 1 abnormal mitotic spindle morphology 0.253974410243199 0.622731735317849 1.09597682907475 0.25 11.1 11 1 increased circulating glucose level 0.039175339726706 0.242224030608906 1.08820394376216 0.24822695035461 11.1 11 1 abnormal epidermal layer morphology 0.12826740087246 0.4866419251151 1.08009310691425 0.246376811594203 11.1 11 1 increased lymphocyte cell number 0.12826740087246 0.4866419251151 1.08009310691425 0.246376811594203 11.1 11 1 increased total body fat amount 0.0487308516151103 0.272094261262821 1.07961896595423 0.246268656716418 11.1 11 1 abnormal long bone morphology 0.148333145057285 0.501383658457645 1.07800999581123 0.245901639344262 11.1 11 1 increased double-negative T cell number 0.148333145057285 0.501383658457645 1.07800999581123 0.245901639344262 11.1 11 1 abnormal facial morphology 0.159809457186656 0.501383658457645 1.07674916540677 0.245614035087719 11.1 11 1 thin ventricular wall 0.0998188322993096 0.411877342812783 1.07162178842864 0.244444444444444 11.1 11 1 abnormal cartilage development 0.201780475155621 0.539418519021608 1.07162178842864 0.244444444444444 11.1 11 1 short ulna 0.218990583333485 0.57613863145642 1.0692456869022 0.24390243902439 11.1 11 1 palatal shelves fail to meet at midline 0.218990583333485 0.57613863145642 1.0692456869022 0.24390243902439 11.1 11 1 lethality at weaning, incomplete penetrance 0.218990583333485 0.57613863145642 1.0692456869022 0.24390243902439 11.1 11 1 abnormal bone structure 0.026861710594271 0.2039583553188 1.06758364697437 0.243523316062176 11.1 11 1 hydroencephaly 0.0735168808806151 0.368696050787359 1.06738612918584 0.243478260869565 11.1 11 1 abnormal vocalization 0.23831321355184 0.592211906803398 1.06635583369435 0.243243243243243 11.1 11 1 increased circulating phosphate level 0.23831321355184 0.592211906803398 1.06635583369435 0.243243243243243 11.1 11 1 increased trabecular bone volume 0.23831321355184 0.592211906803398 1.06635583369435 0.243243243243243 11.1 11 1 decreased B cell number 0.0244216194409842 0.193159867597609 1.06405517385898 0.242718446601942 11.1 11 1 abnormal epidermis stratum basale morphology 0.260196205883467 0.636731984392645 1.06276541001188 0.242424242424242 11.1 11 1 absent vibrissae 0.260196205883467 0.636731984392645 1.06276541001188 0.242424242424242 11.1 11 1 decreased systemic arterial blood pressure 0.260196205883467 0.636731984392645 1.06276541001188 0.242424242424242 11.1 11 1 myeloid hyperplasia 0.260196205883467 0.636731984392645 1.06276541001188 0.242424242424242 11.1 11 1 abnormal CNS synaptic transmission 0.0957072905361192 0.408309848641354 1.06276541001188 0.242424242424242 11.1 11 1 abnormal locomotor activation 0.109556521404287 0.441688568870606 1.05984572481954 0.241758241758242 11.1 11 1 abnormal parietal bone morphology 0.285255396481628 0.67707328124814 1.0581845246239 0.241379310344828 11.1 11 1 decreased granulocyte number 0.285255396481628 0.67707328124814 1.0581845246239 0.241379310344828 11.1 11 1 increased cell proliferation 0.190758297174439 0.51298515050964 1.05538509466457 0.240740740740741 11.1 11 1 hunched posture 0.134872714217223 0.495928864176412 1.05435745581875 0.240506329113924 11.1 11 1 testicular atrophy 0.20631481595286 0.5500622772591 1.05213775591176 0.24 11.1 11 1 abnormal inner ear vestibule morphology 0.314376272864076 0.69247851090235 1.05213775591176 0.24 11.1 11 1 increased pre-B cell number 0.314376272864076 0.69247851090235 1.05213775591176 0.24 11.1 11 1 abnormal feces composition 0.314376272864076 0.69247851090235 1.05213775591176 0.24 11.1 11 1 diaphragmatic hernia 0.314376272864076 0.69247851090235 1.05213775591176 0.24 11.1 11 1 abnormal preimplantation embryo development 0.314376272864076 0.69247851090235 1.05213775591176 0.24 11.1 11 1 decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 0.314376272864076 0.69247851090235 1.05213775591176 0.24 11.1 11 1 azoospermia 0.0549765077664448 0.300796425978452 1.04772627685133 0.238993710691824 11.1 11 1 internal hemorrhage 0.167362133757031 0.501383658457645 1.04690323971319 0.238805970149254 11.1 11 1 spina bifida 0.242873221237005 0.603242274415427 1.04378745626167 0.238095238095238 11.1 11 1 abnormal anxiety-related response 0.348908224292606 0.708517518171908 1.04378745626167 0.238095238095238 11.1 11 1 increased incidence of induced tumors 0.348908224292606 0.708517518171908 1.04378745626167 0.238095238095238 11.1 11 1 abnormal associative learning 0.348908224292606 0.708517518171908 1.04378745626167 0.238095238095238 11.1 11 1 increased vasoconstriction 0.348908224292606 0.708517518171908 1.04378745626167 0.238095238095238 11.1 11 1 left pulmonary isomerism 0.348908224292606 0.708517518171908 1.04378745626167 0.238095238095238 11.1 11 1 abnormal embryonic/fetal subventricular zone morphology 0.348908224292606 0.708517518171908 1.04378745626167 0.238095238095238 11.1 11 1 increased keratinocyte proliferation 0.348908224292606 0.708517518171908 1.04378745626167 0.238095238095238 11.1 11 1 increased muscle cell glucose uptake 0.348908224292606 0.708517518171908 1.04378745626167 0.238095238095238 11.1 11 1 abnormal social investigation 0.147620207634046 0.501383658457645 1.04117798762101 0.2375 11.1 11 1 increased B cell proliferation 0.194386902907831 0.522383908519003 1.04024919369807 0.23728813559322 11.1 11 1 increased bone marrow cell number 0.264560507068469 0.646775686813578 1.03829383807082 0.236842105263158 11.1 11 1 increased grooming behavior 0.264560507068469 0.646775686813578 1.03829383807082 0.236842105263158 11.1 11 1 abnormal contextual conditioning behavior 0.209954323978896 0.55635490830769 1.03619627476158 0.236363636363636 11.1 11 1 abnormal gait 0.0150911615482645 0.138308703187869 1.03568036922274 0.236245954692557 11.1 11 1 kinked tail 0.124204919682622 0.477204559173318 1.03150760383506 0.235294117647059 11.1 11 1 abnormal trabecular bone morphology 0.10352265994581 0.420772249371246 1.03150760383506 0.235294117647059 11.1 11 1 abnormal inhibitory postsynaptic currents 0.183247627785109 0.501383658457645 1.03150760383506 0.235294117647059 11.1 11 1 increased width of hypertrophic chondrocyte zone 0.289160060960395 0.685686989169669 1.03150760383506 0.235294117647059 11.1 11 1 abnormal motor capabilities/coordination/movement 0.0924505799223463 0.399949247924933 1.02955399094901 0.234848484848485 11.1 11 1 decreased bone trabecula number 0.246276834357505 0.610172933729377 1.02602086126147 0.234042553191489 11.1 11 1 decreased insulin secretion 0.152281407646094 0.501383658457645 1.02291170713643 0.233333333333333 11.1 11 1 gastrointestinal hemorrhage 0.317372751912838 0.69247851090235 1.02291170713643 0.233333333333333 11.1 11 1 salivary gland inflammation 0.317372751912838 0.69247851090235 1.02291170713643 0.233333333333333 11.1 11 1 abnormal intestinal mucosa morphology 0.267625549031179 0.65362646363776 1.01951332937186 0.232558139534884 11.1 11 1 abnormal axon guidance 0.267625549031179 0.65362646363776 1.01951332937186 0.232558139534884 11.1 11 1 abnormal neuron morphology 0.144095811816751 0.501383658457645 1.01848351792805 0.232323232323232 11.1 11 1 abnormal coat appearance 0.199845432136098 0.534532809073702 1.01655821827223 0.231884057971014 11.1 11 1 abnormal excitatory postsynaptic potential 0.175041139241543 0.501383658457645 1.01578340255709 0.231707317073171 11.1 11 1 impaired righting response 0.154192159460727 0.501383658457645 1.01522064166924 0.231578947368421 11.1 11 1 ventricular hypoplasia 0.350199915012004 0.708517518171908 1.01167091914592 0.230769230769231 11.1 11 1 abnormal ocular fundus morphology 0.350199915012004 0.708517518171908 1.01167091914592 0.230769230769231 11.1 11 1 abnormal tectorial membrane morphology 0.350199915012004 0.708517518171908 1.01167091914592 0.230769230769231 11.1 11 1 abnormal erythrocyte osmotic lysis 0.350199915012004 0.708517518171908 1.01167091914592 0.230769230769231 11.1 11 1 decreased bone resorption 0.350199915012004 0.708517518171908 1.01167091914592 0.230769230769231 11.1 11 1 abnormal excitatory postsynaptic currents 0.187894579117356 0.506928162206533 1.01167091914592 0.230769230769231 11.1 11 1 abnormal lens fiber morphology 0.291633808783354 0.690565539598852 1.01167091914592 0.230769230769231 11.1 11 1 increased autoantibody level 0.291633808783354 0.690565539598852 1.01167091914592 0.230769230769231 11.1 11 1 decreased trabecular bone volume 0.291633808783354 0.690565539598852 1.01167091914592 0.230769230769231 11.1 11 1 improved glucose tolerance 0.0706792241649999 0.356983898701395 1.00650933282375 0.229591836734694 11.1 11 1 abnormal lipid level 0.189675703399365 0.510349715744642 1.00354504830941 0.228915662650602 11.1 11 1 abnormal response to infection 0.203540375317395 0.543831024277143 0.998864958144076 0.227848101265823 11.1 11 1 abnormal T cell differentiation 0.168156968947691 0.501383658457645 0.99831552747403 0.227722772277228 11.1 11 1 abnormal cytokine secretion 0.112084957309947 0.451516326005658 0.996342571886137 0.227272727272727 11.1 11 1 abnormal vascular development 0.233767528612336 0.581853286315772 0.996342571886136 0.227272727272727 11.1 11 1 osteoporosis 0.293117382147063 0.69247851090235 0.996342571886136 0.227272727272727 11.1 11 1 abnormal abdominal fat pad morphology 0.38915123992542 0.757633122050863 0.996342571886136 0.227272727272727 11.1 11 1 abnormal basisphenoid bone morphology 0.38915123992542 0.757633122050863 0.996342571886136 0.227272727272727 11.1 11 1 abnormal tail movements 0.38915123992542 0.757633122050863 0.996342571886136 0.227272727272727 11.1 11 1 increased activated T cell number 0.38915123992542 0.757633122050863 0.996342571886136 0.227272727272727 11.1 11 1 increased skin papilloma incidence 0.38915123992542 0.757633122050863 0.996342571886136 0.227272727272727 11.1 11 1 abnormal tracheal cartilage morphology 0.38915123992542 0.757633122050863 0.996342571886136 0.227272727272727 11.1 11 1 parakeratosis 0.38915123992542 0.757633122050863 0.996342571886136 0.227272727272727 11.1 11 1 abnormal limb posture 0.38915123992542 0.757633122050863 0.996342571886136 0.227272727272727 11.1 11 1 abnormal mesenteric lymph node morphology 0.38915123992542 0.757633122050863 0.996342571886136 0.227272727272727 11.1 11 1 abnormal cerebral cortex pyramidal cell morphology 0.38915123992542 0.757633122050863 0.996342571886136 0.227272727272727 11.1 11 1 decreased IgM level 0.179819936415459 0.501383658457645 0.994288257304928 0.22680412371134 11.1 11 1 abnormal nervous system electrophysiology 0.204893956247371 0.547153747896227 0.991598083448583 0.226190476190476 11.1 11 1 abnormal body temperature homeostasis 0.350064342234922 0.708517518171908 0.989914555293323 0.225806451612903 11.1 11 1 inner cell mass degeneration 0.350064342234922 0.708517518171908 0.989914555293323 0.225806451612903 11.1 11 1 abnormal podocyte morphology 0.350064342234922 0.708517518171908 0.989914555293323 0.225806451612903 11.1 11 1 small cranium 0.350064342234922 0.708517518171908 0.989914555293323 0.225806451612903 11.1 11 1 abnormal female reproductive system morphology 0.319369281187201 0.69247851090235 0.986379146167275 0.225 11.1 11 1 abnormal craniofacial development 0.293890724049918 0.69247851090235 0.984142458761 0.224489795918367 11.1 11 1 abnormal spermiogenesis 0.272047533124527 0.660212915753425 0.98259991572219 0.224137931034483 11.1 11 1 abnormal digit morphology 0.253498894731097 0.622731735317849 0.974201625844222 0.222222222222222 11.1 11 1 abnormal cochlea morphology 0.294140301923517 0.69247851090235 0.974201625844222 0.222222222222222 11.1 11 1 short radius 0.349091895255415 0.708517518171908 0.974201625844222 0.222222222222222 11.1 11 1 abnormal retinal blood vessel morphology 0.349091895255415 0.708517518171908 0.974201625844222 0.222222222222222 11.1 11 1 rectal prolapse 0.386316443658788 0.757633122050863 0.974201625844222 0.222222222222222 11.1 11 1 abnormal bone trabecula morphology 0.386316443658788 0.757633122050863 0.974201625844222 0.222222222222222 11.1 11 1 decreased bone ossification 0.386316443658788 0.757633122050863 0.974201625844222 0.222222222222222 11.1 11 1 trabecula carnea hypoplasia 0.319213641287474 0.69247851090235 0.974201625844222 0.222222222222222 11.1 11 1 increased circulating corticosterone level 0.319213641287474 0.69247851090235 0.974201625844222 0.222222222222222 11.1 11 1 decreased osteoclast cell number 0.319213641287474 0.69247851090235 0.974201625844222 0.222222222222222 11.1 11 1 lethality at weaning, complete penetrance 0.319213641287474 0.69247851090235 0.974201625844222 0.222222222222222 11.1 11 1 increased bone trabecula number 0.347600789958559 0.708517518171908 0.962321118211976 0.219512195121951 11.1 11 1 increased sacral vertebrae number 0.293547135204872 0.69247851090235 0.958979725440406 0.21875 11.1 11 1 abnormal long term potentiation 0.383074003510438 0.757633122050863 0.958979725440406 0.21875 11.1 11 1 abnormal platelet physiology 0.317634063210388 0.69247851090235 0.956488869010691 0.218181818181818 11.1 11 1 abnormal T-helper 2 physiology 0.317634063210388 0.69247851090235 0.956488869010691 0.218181818181818 11.1 11 1 abnormal immune system physiology 0.208645747790084 0.555978894084449 0.954560464032847 0.217741935483871 11.1 11 1 abnormal skeleton morphology 0.222117753875608 0.58137911282064 0.953023329630217 0.217391304347826 11.1 11 1 hyperkeratosis 0.292863724257967 0.69247851090235 0.953023329630217 0.217391304347826 11.1 11 1 abnormal food intake 0.292863724257967 0.69247851090235 0.953023329630217 0.217391304347826 11.1 11 1 abnormal cell death 0.345776689088681 0.705305054619184 0.953023329630217 0.217391304347826 11.1 11 1 fragile skeleton 0.429202746506985 0.803223684542179 0.953023329630217 0.217391304347826 11.1 11 1 abnormal carpal bone morphology 0.429202746506985 0.803223684542179 0.953023329630217 0.217391304347826 11.1 11 1 blistering 0.429202746506985 0.803223684542179 0.953023329630217 0.217391304347826 11.1 11 1 conjunctivitis 0.429202746506985 0.803223684542179 0.953023329630217 0.217391304347826 11.1 11 1 pancreas inflammation 0.429202746506985 0.803223684542179 0.953023329630217 0.217391304347826 11.1 11 1 abnormal nasal cavity morphology 0.429202746506985 0.803223684542179 0.953023329630217 0.217391304347826 11.1 11 1 increased susceptibility to age related obesity 0.429202746506985 0.803223684542179 0.953023329630217 0.217391304347826 11.1 11 1 decreased epididymis weight 0.429202746506985 0.803223684542179 0.953023329630217 0.217391304347826 11.1 11 1 abnormal breathing pattern 0.379651531587435 0.757633122050863 0.947871852172757 0.216216216216216 11.1 11 1 impaired skeletal muscle contractility 0.379651531587435 0.757633122050863 0.947871852172757 0.216216216216216 11.1 11 1 increased insulin secretion 0.379651531587435 0.757633122050863 0.947871852172757 0.216216216216216 11.1 11 1 abnormal humerus morphology 0.379651531587435 0.757633122050863 0.947871852172757 0.216216216216216 11.1 11 1 increased T cell number 0.270978970306828 0.657940642887491 0.94652544329183 0.215909090909091 11.1 11 1 increased lung adenocarcinoma incidence 0.343734413138084 0.703932378387763 0.945548636848804 0.215686274509804 11.1 11 1 abnormal seminal vesicle morphology 0.341548185870191 0.701569869820067 0.9394087106355 0.214285714285714 11.1 11 1 abnormal stria vascularis morphology 0.422409725499402 0.803223684542179 0.9394087106355 0.214285714285714 11.1 11 1 myoclonus 0.422409725499402 0.803223684542179 0.9394087106355 0.214285714285714 11.1 11 1 increased circulating luteinizing hormone level 0.422409725499402 0.803223684542179 0.9394087106355 0.214285714285714 11.1 11 1 abnormal spleen germinal center morphology 0.422409725499402 0.803223684542179 0.9394087106355 0.214285714285714 11.1 11 1 increased leukocyte cell number 0.219801151652225 0.577965501833942 0.937249150381166 0.213793103448276 11.1 11 1 increased B cell number 0.250409759289701 0.620103809092215 0.936732332542521 0.213675213675214 11.1 11 1 abnormal innervation 0.372668541718729 0.752445614874462 0.932746237510426 0.212765957446809 11.1 11 1 abnormal T-helper 1 physiology 0.372668541718729 0.752445614874462 0.932746237510426 0.212765957446809 11.1 11 1 abnormal locomotor coordination 0.416156487486931 0.803223684542179 0.929919733760394 0.212121212121212 11.1 11 1 abnormal QRS complex 0.416156487486931 0.803223684542179 0.929919733760394 0.212121212121212 11.1 11 1 abnormal middle ear ossicle morphology 0.416156487486931 0.803223684542179 0.929919733760394 0.212121212121212 11.1 11 1 decreased IgA level 0.369201991908787 0.746051953593102 0.927365009217096 0.211538461538462 11.1 11 1 abnormal spatial learning 0.253666903201969 0.622731735317849 0.914434654933534 0.208588957055215 11.1 11 1 abnormal inflammatory response 0.355879450981857 0.719715556355584 0.913314024228958 0.208333333333333 11.1 11 1 abnormal cardiovascular system morphology 0.399752913814583 0.772938494452992 0.913314024228958 0.208333333333333 11.1 11 1 abnormal lymph node morphology 0.399752913814583 0.772938494452992 0.913314024228958 0.208333333333333 11.1 11 1 abnormal osteoclast morphology 0.399752913814583 0.772938494452992 0.913314024228958 0.208333333333333 11.1 11 1 abnormal nursing 0.468681945694144 0.816133244602158 0.913314024228958 0.208333333333333 11.1 11 1 increased stereotypic behavior 0.468681945694144 0.816133244602158 0.913314024228958 0.208333333333333 11.1 11 1 apnea 0.468681945694144 0.816133244602158 0.913314024228958 0.208333333333333 11.1 11 1 small lymph nodes 0.468681945694144 0.816133244602158 0.913314024228958 0.208333333333333 11.1 11 1 increased hemangiosarcoma incidence 0.468681945694144 0.816133244602158 0.913314024228958 0.208333333333333 11.1 11 1 increased neutrophil cell number 0.28608452171636 0.67871745137763 0.907015306820483 0.206896551724138 11.1 11 1 abnormal middle ear morphology 0.458189115677952 0.803223684542179 0.907015306820483 0.206896551724138 11.1 11 1 focal hair loss 0.458189115677952 0.803223684542179 0.907015306820483 0.206896551724138 11.1 11 1 decreased retinal photoreceptor cell number 0.458189115677952 0.803223684542179 0.907015306820483 0.206896551724138 11.1 11 1 absent long term depression 0.458189115677952 0.803223684542179 0.907015306820483 0.206896551724138 11.1 11 1 increased retinal apoptosis 0.458189115677952 0.803223684542179 0.907015306820483 0.206896551724138 11.1 11 1 abnormal eye electrophysiology 0.31100608112099 0.69247851090235 0.905765974441942 0.206611570247934 11.1 11 1 abnormal oocyte morphology 0.449081486956772 0.803223684542179 0.902569153355677 0.205882352941176 11.1 11 1 lung hemorrhage 0.449081486956772 0.803223684542179 0.902569153355677 0.205882352941176 11.1 11 1 impaired synaptic plasticity 0.449081486956772 0.803223684542179 0.902569153355677 0.205882352941176 11.1 11 1 abnormal vision 0.449081486956772 0.803223684542179 0.902569153355677 0.205882352941176 11.1 11 1 abnormal skin physiology 0.449081486956772 0.803223684542179 0.902569153355677 0.205882352941176 11.1 11 1 increased susceptibility to viral infection induced morbidity/mortality 0.449081486956772 0.803223684542179 0.902569153355677 0.205882352941176 11.1 11 1 short femur 0.365986495871407 0.739854862641303 0.896708314697523 0.204545454545455 11.1 11 1 abnormal epidermis stratum corneum morphology 0.426897065036293 0.803223684542179 0.89467496251 0.204081632653061 11.1 11 1 decreased platelet aggregation 0.420648043542965 0.803223684542179 0.89301815702387 0.203703703703704 11.1 11 1 abnormal T cell activation 0.399163899710574 0.772700545159574 0.888629861411959 0.202702702702703 11.1 11 1 decreased double-positive T cell number 0.396026502745506 0.766925594067299 0.8767814632598 0.2 11.1 11 1 abnormal ovarian follicle morphology 0.462241215422425 0.806611731577188 0.8767814632598 0.2 11.1 11 1 abnormal dermal layer morphology 0.4816367515761 0.835183980164202 0.8767814632598 0.2 11.1 11 1 increased metastatic potential 0.49339320661923 0.852598542178072 0.8767814632598 0.2 11.1 11 1 abnormal response to new environment 0.49339320661923 0.852598542178072 0.8767814632598 0.2 11.1 11 1 arrested T cell differentiation 0.49339320661923 0.852598542178072 0.8767814632598 0.2 11.1 11 1 abnormal spleen marginal zone morphology 0.49339320661923 0.852598542178072 0.8767814632598 0.2 11.1 11 1 abnormal keratinocyte physiology 0.507258363901661 0.87231605959584 0.8767814632598 0.2 11.1 11 1 abnormal stomach mucosa morphology 0.507258363901661 0.87231605959584 0.8767814632598 0.2 11.1 11 1 decreased IgG level 0.405162178676087 0.783093177511086 0.86888253115836 0.198198198198198 11.1 11 1 increased susceptibility to pharmacologically induced seizures 0.419837421303758 0.803223684542179 0.86764832301751 0.197916666666667 11.1 11 1 abnormal NK cell physiology 0.463921959801766 0.809260781912267 0.862407996648984 0.19672131147541 11.1 11 1 abnormal cued conditioning behavior 0.480860990105188 0.834761198841033 0.859589669862549 0.196078431372549 11.1 11 1 abnormal inner ear morphology 0.490570424530632 0.84890012592692 0.857720996667196 0.195652173913043 11.1 11 1 abnormal immune system morphology 0.490570424530632 0.84890012592692 0.857720996667196 0.195652173913043 11.1 11 1 abnormal sleep pattern 0.490570424530632 0.84890012592692 0.857720996667196 0.195652173913043 11.1 11 1 delayed wound healing 0.490570424530632 0.84890012592692 0.857720996667196 0.195652173913043 11.1 11 1 scaly skin 0.501385697185597 0.862813505187943 0.855396549521756 0.195121951219512 11.1 11 1 arrested B cell differentiation 0.501385697185597 0.862813505187943 0.855396549521756 0.195121951219512 11.1 11 1 increased susceptibility to bacterial infection induced morbidity/mortality 0.471973789611999 0.821577887795554 0.852426422613695 0.194444444444444 11.1 11 1 maternal effect 0.479830795699687 0.834761198841033 0.85060888226697 0.194029850746269 11.1 11 1 osteopetrosis 0.527792134071464 0.891904166781771 0.848498190251419 0.193548387096774 11.1 11 1 abnormal CD8-positive, alpha beta T cell morphology 0.527792134071464 0.891904166781771 0.848498190251419 0.193548387096774 11.1 11 1 abnormal nasal bone morphology 0.544653232684913 0.898225183470062 0.843059099288269 0.192307692307692 11.1 11 1 abnormal xiphoid process morphology 0.544653232684913 0.898225183470062 0.843059099288269 0.192307692307692 11.1 11 1 pulmonary edema 0.544653232684913 0.898225183470062 0.843059099288269 0.192307692307692 11.1 11 1 decreased Peyer's patch number 0.544653232684913 0.898225183470062 0.843059099288269 0.192307692307692 11.1 11 1 increased systemic arterial blood pressure 0.518494554670293 0.880505279922337 0.839471613759383 0.191489361702128 11.1 11 1 increased circulating HDL cholesterol level 0.489744696967439 0.848651991436088 0.835029965009333 0.19047619047619 11.1 11 1 abnormal humoral immune response 0.489744696967439 0.848651991436088 0.835029965009333 0.19047619047619 11.1 11 1 abnormal muscle morphology 0.530849895545655 0.89676680147356 0.835029965009333 0.19047619047619 11.1 11 1 abnormal embryonic neuroepithelium morphology 0.522530814513442 0.885117739940203 0.831430697918776 0.189655172413793 11.1 11 1 increased brown adipose tissue amount 0.544892058983865 0.898225183470062 0.829387870651162 0.189189189189189 11.1 11 1 decreased circulating chloride level 0.544892058983865 0.898225183470062 0.829387870651162 0.189189189189189 11.1 11 1 abnormal calcium ion homeostasis 0.544892058983865 0.898225183470062 0.829387870651162 0.189189189189189 11.1 11 1 skin inflammation 0.544892058983865 0.898225183470062 0.829387870651162 0.189189189189189 11.1 11 1 abnormal pancreatic islet morphology 0.53362519094492 0.898225183470062 0.82715232383 0.188679245283019 11.1 11 1 abnormal lumbar vertebrae morphology 0.561188625739393 0.898877467177553 0.821982621806063 0.1875 11.1 11 1 abnormal embryonic hematopoiesis 0.561188625739393 0.898877467177553 0.821982621806063 0.1875 11.1 11 1 abnormal phalanx morphology 0.545896471790842 0.898225183470062 0.821982621806063 0.1875 11.1 11 1 abnormal vasculogenesis 0.559639970578616 0.898225183470062 0.815610663497488 0.186046511627907 11.1 11 1 decreased susceptibility to pharmacologically induced seizures 0.580638866554487 0.919668373482512 0.811834688203519 0.185185185185185 11.1 11 1 abnormal compact bone morphology 0.575274223908799 0.91838023438403 0.807561874055079 0.184210526315789 11.1 11 1 decreased total retina thickness 0.575274223908799 0.91838023438403 0.807561874055079 0.184210526315789 11.1 11 1 dilated heart atrium 0.593417989795496 0.936035034633035 0.797074057508909 0.181818181818182 11.1 11 1 cardiovascular system phenotype 0.593417989795496 0.936035034633035 0.797074057508909 0.181818181818182 11.1 11 1 abnormal neuromuscular synapse morphology 0.592736410425272 0.936035034633035 0.791538820998431 0.180555555555556 11.1 11 1 abnormal leukocyte adhesion 0.604651749283522 0.95124561527321 0.786855159335718 0.179487179487179 11.1 11 1 decreased anxiety-related response 0.614213316588712 0.965469589266617 0.784113503728276 0.178861788617886 11.1 11 1 decreased inflammatory response 0.611150369105427 0.960958623988464 0.78284059219625 0.178571428571429 11.1 11 1 failure of blastocyst to hatch from the zona pellucida 0.615036505914287 0.966458186015028 0.78284059219625 0.178571428571429 11.1 11 1 decreased pancreatic beta cell number 0.624347240403794 0.970921742257609 0.773630702876294 0.176470588235294 11.1 11 1 decreased osteoblast cell number 0.624347240403794 0.970921742257609 0.773630702876294 0.176470588235294 11.1 11 1 increased granulocyte number 0.634801612488971 0.970921742257609 0.770145879890365 0.175675675675676 11.1 11 1 skin lesions 0.640465731003382 0.970921742257609 0.765444134591889 0.174603174603175 11.1 11 1 abnormal lymphocyte physiology 0.640898357292659 0.970921742257609 0.762418663704174 0.173913043478261 11.1 11 1 abnormal female meiosis 0.648375546582256 0.979255720779212 0.758753189359442 0.173076923076923 11.1 11 1 abnormal circulating glucose level 0.647713045546857 0.97855220212439 0.755846089017069 0.172413793103448 11.1 11 1 increased susceptibility to induced arthritis 0.647713045546857 0.97855220212439 0.755846089017069 0.172413793103448 11.1 11 1 abnormal CD8-positive, alpha-beta T cell physiology 0.647713045546857 0.97855220212439 0.755846089017069 0.172413793103448 11.1 11 1 abnormal thoracic vertebrae morphology 0.677510157639775 1 0.743035138355763 0.169491525423729 11.1 11 1 increased hemoglobin content 0.677510157639775 1 0.743035138355763 0.169491525423729 11.1 11 1 decreased T cell proliferation 0.732273565504984 1 0.740524884509966 0.168918918918919 11.1 11 1 abnormal systemic arterial blood pressure 0.681922190607624 1 0.730651219383167 0.166666666666667 11.1 11 1 abnormal epidermis stratum granulosum morphology 0.681922190607624 1 0.730651219383167 0.166666666666667 11.1 11 1 impaired wound healing 0.681922190607624 1 0.730651219383167 0.166666666666667 11.1 11 1 abnormal reflex 0.681922190607624 1 0.730651219383167 0.166666666666667 11.1 11 1 abnormal cartilage morphology 0.685833264193064 1 0.730651219383167 0.166666666666667 11.1 11 1 abnormal cytotoxic T cell physiology 0.685833264193064 1 0.730651219383167 0.166666666666667 11.1 11 1 abnormal male meiosis 0.719052553403146 1 0.71867333054082 0.163934426229508 11.1 11 1 abnormal pancreatic beta cell physiology 0.708444151567061 1 0.710903889129567 0.162162162162162 11.1 11 1 enhanced long term potentiation 0.736371133739148 1 0.704556532976625 0.160714285714286 11.1 11 1 increased monocyte cell number 0.782723694112399 1 0.70142517060784 0.16 11.1 11 1 decreased macrophage cell number 0.733590024932578 1 0.697439800320296 0.159090909090909 11.1 11 1 impaired natural killer cell mediated cytotoxicity 0.755844418258077 1 0.692195892047211 0.157894736842105 11.1 11 1 decreased susceptibility to parasitic infection 0.734682527675453 1 0.684985518171719 0.15625 11.1 11 1 decreased monocyte cell number 0.791161765486647 1 0.674447279430615 0.153846153846154 11.1 11 1 abnormal leukocyte migration 0.774711505784149 1 0.674447279430615 0.153846153846154 11.1 11 1 abnormal heart looping 0.75682474277016 1 0.674447279430615 0.153846153846154 11.1 11 1 increased vascular permeability 0.75682474277016 1 0.674447279430615 0.153846153846154 11.1 11 1 abnormal T cell subpopulation ratio 0.75990833801116 1 0.664228381257424 0.151515151515152 11.1 11 1 thin skin 0.783280941046913 1 0.644692252396912 0.147058823529412 11.1 11 1 decreased regulatory T cell number 0.783280941046913 1 0.644692252396912 0.147058823529412 11.1 11 1 decreased cytotoxic T cell cytolysis 0.783280941046913 1 0.644692252396912 0.147058823529412 11.1 11 1 abnormal spleen white pulp morphology 0.817903550221274 1 0.626272473757 0.142857142857143 11.1 11 1 impaired macrophage phagocytosis 0.835341285544312 1 0.611707997623116 0.13953488372093 11.1 11 1 impaired hematopoiesis 0.859877339394401 1 0.601712768903784 0.137254901960784 11.1 11 1 increased susceptibility to parasitic infection 0.926621592818967 1 0.584520975506533 0.133333333333333 11.1 11 1 decreased threshold for auditory brainstem response 0.859416202312148 1 0.576829910039342 0.131578947368421 11.1 11 1 impaired macrophage chemotaxis 0.874503181656558 1 0.562039399525513 0.128205128205128 11.1 11 1 decreased tumor growth/size 0.951683409501859 1 0.487100812922111 0.111111111111111 11.1 11 1 cleft upper lip 4.81046738419358e-07 7.74500816710779e-06 0.936632985100188 1 11.5 11 5 abnormal pericardium morphology 1.80623386905028e-06 2.44850504047007e-05 0.936632985100188 1 11.5 11 5 anencephaly 1.80623386905028e-06 2.44850504047007e-05 0.936632985100188 1 11.5 11 5 increased skin tumor incidence 1.80623386905028e-06 2.44850504047007e-05 0.936632985100188 1 11.5 11 5 kyphoscoliosis 3.49984908733283e-06 4.47602807441666e-05 0.936632985100188 1 11.5 11 5 increased liver adenoma incidence 3.49984908733283e-06 4.47602807441666e-05 0.936632985100188 1 11.5 11 5 aminoaciduria 1.31390499053504e-05 0.000146562271926274 0.936632985100188 1 11.5 11 5 abnormal fontanelle morphology 4.93208525022096e-05 0.00047552566123739 0.936632985100188 1 11.5 11 5 decreased hepatocyte number 4.93208525022096e-05 0.00047552566123739 0.936632985100188 1 11.5 11 5 abnormal ear development 4.93208525022096e-05 0.00047552566123739 0.936632985100188 1 11.5 11 5 abnormal mineral level 0.000358624910067191 0.00269510412021794 0.936632985100188 1 11.5 11 5 abnormal thymus involution 0.000358624910067191 0.00269510412021794 0.936632985100188 1 11.5 11 5 increased osteosarcoma incidence 0.000358624910067191 0.00269510412021794 0.936632985100188 1 11.5 11 5 pale placenta 0.000358624910067191 0.00269510412021794 0.936632985100188 1 11.5 11 5 abnormal fatty acid level 0.000358624910067191 0.00269510412021794 0.936632985100188 1 11.5 11 5 decreased red blood cell distribution width 0.000358624910067191 0.00269510412021794 0.936632985100188 1 11.5 11 5 embryonic lethality between implantation and placentation, incomplete penetrance 0.000358624910067191 0.00269510412021794 0.936632985100188 1 11.5 11 5 absent semicircular canals 0.000694735894842263 0.0047024640501228 0.936632985100188 1 11.5 11 5 decreased atrioventricular cushion size 0.000694735894842263 0.0047024640501228 0.936632985100188 1 11.5 11 5 abnormal eye distance/ position 0.000694735894842263 0.0047024640501228 0.936632985100188 1 11.5 11 5 abnormal hypothalamus secretion 0.000694735894842263 0.0047024640501228 0.936632985100188 1 11.5 11 5 pharyngeal arch hypoplasia 0.000694735894842263 0.0047024640501228 0.936632985100188 1 11.5 11 5 increased glycogen level 0.000694735894842263 0.0047024640501228 0.936632985100188 1 11.5 11 5 abnormal palatal shelf elevation 0.000694735894842263 0.0047024640501228 0.936632985100188 1 11.5 11 5 increased number of Howell-Jolly bodies 0.000694735894842263 0.0047024640501228 0.936632985100188 1 11.5 11 5 aorta dilation 0.000694735894842263 0.0047024640501228 0.936632985100188 1 11.5 11 5 common atrioventricular valve 0.000694735894842263 0.0047024640501228 0.936632985100188 1 11.5 11 5 abnormal pulmonary alveolar sac morphology 0.000694735894842263 0.0047024640501228 0.936632985100188 1 11.5 11 5 abnormal respiratory mechanics 0.00134582013695553 0.00799234727553344 0.936632985100188 1 11.5 11 5 impaired basement membrane formation 0.00134582013695553 0.00799234727553344 0.936632985100188 1 11.5 11 5 increased heart rate variability 0.00134582013695553 0.00799234727553344 0.936632985100188 1 11.5 11 5 abnormal plasma membrane morphology 0.00134582013695553 0.00799234727553344 0.936632985100188 1 11.5 11 5 abnormal respiratory conducting tube morphology 0.00134582013695553 0.00799234727553344 0.936632985100188 1 11.5 11 5 osteosclerosis 0.00134582013695553 0.00799234727553344 0.936632985100188 1 11.5 11 5 crystalluria 0.00134582013695553 0.00799234727553344 0.936632985100188 1 11.5 11 5 increased circulating fructosamine level 0.00134582013695553 0.00799234727553344 0.936632985100188 1 11.5 11 5 abnormal left subclavian artery morphology 0.00134582013695553 0.00799234727553344 0.936632985100188 1 11.5 11 5 thin ventricle myocardium compact layer 0.00134582013695553 0.00799234727553344 0.936632985100188 1 11.5 11 5 abnormal pulmonary interalveolar septum morphology 0.00134582013695553 0.00799234727553344 0.936632985100188 1 11.5 11 5 decreased circulating lactate level 0.00134582013695553 0.00799234727553344 0.936632985100188 1 11.5 11 5 increased fatty acid oxidation 0.00134582013695553 0.00799234727553344 0.936632985100188 1 11.5 11 5 arrest of tooth development 0.0189468127333443 0.0705541866380149 0.936632985100188 1 11.5 11 5 abnormal urethra morphology 0.0189468127333443 0.0705541866380149 0.936632985100188 1 11.5 11 5 thin tail 0.0189468127333443 0.0705541866380149 0.936632985100188 1 11.5 11 5 abnormal lacrimal gland physiology 0.0189468127333443 0.0705541866380149 0.936632985100188 1 11.5 11 5 increased embryo size 0.0189468127333443 0.0705541866380149 0.936632985100188 1 11.5 11 5 absent ectoplacental cone 0.0189468127333443 0.0705541866380149 0.936632985100188 1 11.5 11 5 delayed brain development 0.0189468127333443 0.0705541866380149 0.936632985100188 1 11.5 11 5 non-obstructive hydrocephaly 0.0189468127333443 0.0705541866380149 0.936632985100188 1 11.5 11 5 abnormal blood gas level 0.0189468127333443 0.0705541866380149 0.936632985100188 1 11.5 11 5 abnormal hippocampal fimbria morphology 0.0189468127333443 0.0705541866380149 0.936632985100188 1 11.5 11 5 acidemia 0.0189468127333443 0.0705541866380149 0.936632985100188 1 11.5 11 5 phenotypic reversion 0.0189468127333443 0.0705541866380149 0.936632985100188 1 11.5 11 5 calcified joint 0.0189468127333443 0.0705541866380149 0.936632985100188 1 11.5 11 5 bile duct inflammation 0.0189468127333443 0.0705541866380149 0.936632985100188 1 11.5 11 5 esophageal atresia 0.0189468127333443 0.0705541866380149 0.936632985100188 1 11.5 11 5 enlarged pancreas 0.0189468127333443 0.0705541866380149 0.936632985100188 1 11.5 11 5 abnormal leukocyte tethering or rolling 0.0189468127333443 0.0705541866380149 0.936632985100188 1 11.5 11 5 decreased heart right ventricle size 0.0189468127333443 0.0705541866380149 0.936632985100188 1 11.5 11 5 matted coat 0.0189468127333443 0.0705541866380149 0.936632985100188 1 11.5 11 5 abnormal heart left atrium morphology 0.0189468127333443 0.0705541866380149 0.936632985100188 1 11.5 11 5 absent parietal bone 0.0189468127333443 0.0705541866380149 0.936632985100188 1 11.5 11 5 decreased prostate gland weight 0.0189468127333443 0.0705541866380149 0.936632985100188 1 11.5 11 5 osteomyelitis 0.0189468127333443 0.0705541866380149 0.936632985100188 1 11.5 11 5 abnormal heart size 0.0189468127333443 0.0705541866380149 0.936632985100188 1 11.5 11 5 increased triiodothyronine level 0.0189468127333443 0.0705541866380149 0.936632985100188 1 11.5 11 5 abnormal dermis papillary layer morphology 0.0189468127333443 0.0705541866380149 0.936632985100188 1 11.5 11 5 decreased platelet ADP level 0.0189468127333443 0.0705541866380149 0.936632985100188 1 11.5 11 5 abnormal right lung morphology 0.0189468127333443 0.0705541866380149 0.936632985100188 1 11.5 11 5 abnormal eyelid development 0.0189468127333443 0.0705541866380149 0.936632985100188 1 11.5 11 5 delayed chorioallantoic fusion 0.0189468127333443 0.0705541866380149 0.936632985100188 1 11.5 11 5 increased urine uric acid level 0.0189468127333443 0.0705541866380149 0.936632985100188 1 11.5 11 5 abnormal aorta tunica adventitia morphology 0.0189468127333443 0.0705541866380149 0.936632985100188 1 11.5 11 5 abnormal olfactory bulb layer morphology 0.0189468127333443 0.0705541866380149 0.936632985100188 1 11.5 11 5 abnormal renal water reabsorbtion 0.0189468127333443 0.0705541866380149 0.936632985100188 1 11.5 11 5 myocardium hypoplasia 0.0189468127333443 0.0705541866380149 0.936632985100188 1 11.5 11 5 cerebral arteriovenous malformation 0.0189468127333443 0.0705541866380149 0.936632985100188 1 11.5 11 5 increased total lung capacity 0.0189468127333443 0.0705541866380149 0.936632985100188 1 11.5 11 5 abnormal mandibular prominence morphology 0.0189468127333443 0.0705541866380149 0.936632985100188 1 11.5 11 5 abnormal endocrine pancreas development 0.0189468127333443 0.0705541866380149 0.936632985100188 1 11.5 11 5 thymus cortex atrophy 0.0189468127333443 0.0705541866380149 0.936632985100188 1 11.5 11 5 ectopic bone 0.0189468127333443 0.0705541866380149 0.936632985100188 1 11.5 11 5 decreased hippocampus volume 0.0189468127333443 0.0705541866380149 0.936632985100188 1 11.5 11 5 decreased capillary density 0.0189468127333443 0.0705541866380149 0.936632985100188 1 11.5 11 5 absent neurocranium 0.036698089373133 0.119172972996956 0.936632985100188 1 11.5 11 5 abnormal circulating HDL cholesterol level 0.036698089373133 0.119172972996956 0.936632985100188 1 11.5 11 5 small hair follicles 0.036698089373133 0.119172972996956 0.936632985100188 1 11.5 11 5 delayed intestine development 0.036698089373133 0.119172972996956 0.936632985100188 1 11.5 11 5 ulcerated paws 0.036698089373133 0.119172972996956 0.936632985100188 1 11.5 11 5 abnormal pineal gland morphology 0.036698089373133 0.119172972996956 0.936632985100188 1 11.5 11 5 optic nerve atrophy 0.036698089373133 0.119172972996956 0.936632985100188 1 11.5 11 5 absent lungs 0.036698089373133 0.119172972996956 0.936632985100188 1 11.5 11 5 decreased sensitivity to skin irradiation 0.036698089373133 0.119172972996956 0.936632985100188 1 11.5 11 5 kinked vibrissae 0.036698089373133 0.119172972996956 0.936632985100188 1 11.5 11 5 corneal scarring 0.036698089373133 0.119172972996956 0.936632985100188 1 11.5 11 5 vascular inflammation 0.036698089373133 0.119172972996956 0.936632985100188 1 11.5 11 5 abnormal respiratory sounds 0.036698089373133 0.119172972996956 0.936632985100188 1 11.5 11 5 increased hepatic hemangioma incidence 0.036698089373133 0.119172972996956 0.936632985100188 1 11.5 11 5 abnormal nasal mucosa morphology 0.036698089373133 0.119172972996956 0.936632985100188 1 11.5 11 5 abnormal oropharynx morphology 0.036698089373133 0.119172972996956 0.936632985100188 1 11.5 11 5 abnormal type I pneumocyte morphology 0.036698089373133 0.119172972996956 0.936632985100188 1 11.5 11 5 abnormal lung compliance 0.036698089373133 0.119172972996956 0.936632985100188 1 11.5 11 5 improved righting response 0.036698089373133 0.119172972996956 0.936632985100188 1 11.5 11 5 increased urine microalbumin level 0.036698089373133 0.119172972996956 0.936632985100188 1 11.5 11 5 abnormal urine osmolality 0.036698089373133 0.119172972996956 0.936632985100188 1 11.5 11 5 alkalosis 0.036698089373133 0.119172972996956 0.936632985100188 1 11.5 11 5 gastric polyps 0.036698089373133 0.119172972996956 0.936632985100188 1 11.5 11 5 epidermal cyst 0.036698089373133 0.119172972996956 0.936632985100188 1 11.5 11 5 sirenomelia 0.036698089373133 0.119172972996956 0.936632985100188 1 11.5 11 5 absent vas deferens 0.036698089373133 0.119172972996956 0.936632985100188 1 11.5 11 5 absent uterus 0.036698089373133 0.119172972996956 0.936632985100188 1 11.5 11 5 abnormal response to vitamins 0.036698089373133 0.119172972996956 0.936632985100188 1 11.5 11 5 decreased skin turgor 0.036698089373133 0.119172972996956 0.936632985100188 1 11.5 11 5 ectopic cartilage 0.036698089373133 0.119172972996956 0.936632985100188 1 11.5 11 5 increased allantois apoptosis 0.036698089373133 0.119172972996956 0.936632985100188 1 11.5 11 5 increased heart right ventricle weight 0.036698089373133 0.119172972996956 0.936632985100188 1 11.5 11 5 abnormal urinary system development 0.036698089373133 0.119172972996956 0.936632985100188 1 11.5 11 5 absent utricle 0.036698089373133 0.119172972996956 0.936632985100188 1 11.5 11 5 absent frontal bone 0.036698089373133 0.119172972996956 0.936632985100188 1 11.5 11 5 abnormal inner cell mass proliferation 0.036698089373133 0.119172972996956 0.936632985100188 1 11.5 11 5 abnormal tail pigmentation 0.036698089373133 0.119172972996956 0.936632985100188 1 11.5 11 5 decreased unsaturated fatty acid level 0.036698089373133 0.119172972996956 0.936632985100188 1 11.5 11 5 growth retardation of incisors 0.036698089373133 0.119172972996956 0.936632985100188 1 11.5 11 5 increased circulating atrial natriuretic factor 0.036698089373133 0.119172972996956 0.936632985100188 1 11.5 11 5 abnormal hemoglobin content 0.036698089373133 0.119172972996956 0.936632985100188 1 11.5 11 5 increased placenta apoptosis 0.036698089373133 0.119172972996956 0.936632985100188 1 11.5 11 5 absent optic chiasm 0.036698089373133 0.119172972996956 0.936632985100188 1 11.5 11 5 enlarged eye anterior chamber 0.036698089373133 0.119172972996956 0.936632985100188 1 11.5 11 5 abnormal arcus anterior morphology 0.036698089373133 0.119172972996956 0.936632985100188 1 11.5 11 5 palatal shelf fusion with tongue or mandible 0.036698089373133 0.119172972996956 0.936632985100188 1 11.5 11 5 abnormal hyoid bone greater horn morphology 0.036698089373133 0.119172972996956 0.936632985100188 1 11.5 11 5 abnormal cerebellum lobule morphology 0.036698089373133 0.119172972996956 0.936632985100188 1 11.5 11 5 aciduria 0.036698089373133 0.119172972996956 0.936632985100188 1 11.5 11 5 increased response to stress-induced hyperthermia 0.036698089373133 0.119172972996956 0.936632985100188 1 11.5 11 5 leptocytosis 0.036698089373133 0.119172972996956 0.936632985100188 1 11.5 11 5 increased T follicular helper cell number 0.036698089373133 0.119172972996956 0.936632985100188 1 11.5 11 5 increased thyroid carcinoma incidence 0.036698089373133 0.119172972996956 0.936632985100188 1 11.5 11 5 abnormal second pharyngeal arch artery morphology 0.036698089373133 0.119172972996956 0.936632985100188 1 11.5 11 5 increased renal carcinoma incidence 0.036698089373133 0.119172972996956 0.936632985100188 1 11.5 11 5 calcified aorta 0.036698089373133 0.119172972996956 0.936632985100188 1 11.5 11 5 aorta hypoplasia 0.036698089373133 0.119172972996956 0.936632985100188 1 11.5 11 5 decreased heart left ventricle size 0.036698089373133 0.119172972996956 0.936632985100188 1 11.5 11 5 enlarged aortic valve 0.036698089373133 0.119172972996956 0.936632985100188 1 11.5 11 5 abnormal skin adnexa morphology 0.036698089373133 0.119172972996956 0.936632985100188 1 11.5 11 5 increased Schwann cell number 0.036698089373133 0.119172972996956 0.936632985100188 1 11.5 11 5 trachea stenosis 0.036698089373133 0.119172972996956 0.936632985100188 1 11.5 11 5 abnormal lung alveolus development 0.036698089373133 0.119172972996956 0.936632985100188 1 11.5 11 5 impaired branching involved in terminal bronchiole morphogenesis 0.036698089373133 0.119172972996956 0.936632985100188 1 11.5 11 5 delayed optic fissure closure 0.036698089373133 0.119172972996956 0.936632985100188 1 11.5 11 5 abnormal mammary gland bud morphology 0.036698089373133 0.119172972996956 0.936632985100188 1 11.5 11 5 abnormal mitophagy 0.036698089373133 0.119172972996956 0.936632985100188 1 11.5 11 5 decreased small intestinal villus height 0.036698089373133 0.119172972996956 0.936632985100188 1 11.5 11 5 decreased neuronal precursor proliferation 0.036698089373133 0.119172972996956 0.936632985100188 1 11.5 11 5 cystinuria 0.036698089373133 0.119172972996956 0.936632985100188 1 11.5 11 5 decreased fibroblast chemotaxis 0.036698089373133 0.119172972996956 0.936632985100188 1 11.5 11 5 increased muscle cell glucose uptake 9.32151781700474e-07 1.38295541581964e-05 0.936632985100188 1 11.5 11 5 abnormal interparietal bone morphology 9.55533399045837e-05 0.000856536695541088 0.936632985100188 1 11.5 11 5 midline facial cleft 9.55533399045837e-05 0.000856536695541088 0.936632985100188 1 11.5 11 5 irregularly shaped pupil 9.55533399045837e-05 0.000856536695541088 0.936632985100188 1 11.5 11 5 increased hemangioma incidence 9.55533399045837e-05 0.000856536695541088 0.936632985100188 1 11.5 11 5 split sternum 9.55533399045837e-05 0.000856536695541088 0.936632985100188 1 11.5 11 5 lysosomal protein accumulation 9.55533399045837e-05 0.000856536695541088 0.936632985100188 1 11.5 11 5 abnormal renal tubule epithelial cell primary cilium morphology 9.55533399045837e-05 0.000856536695541088 0.936632985100188 1 11.5 11 5 abnormal exocrine pancreas morphology 0.000185118219235851 0.00151225474663113 0.936632985100188 1 11.5 11 5 increased prostaglandin level 0.000185118219235851 0.00151225474663113 0.936632985100188 1 11.5 11 5 synostosis 0.00260700765049389 0.0141747137280952 0.936632985100188 1 11.5 11 5 dilated uterus 0.00260700765049389 0.0141747137280952 0.936632985100188 1 11.5 11 5 decreased circulating bicarbonate level 0.00260700765049389 0.0141747137280952 0.936632985100188 1 11.5 11 5 premature bone ossification 0.00260700765049389 0.0141747137280952 0.936632985100188 1 11.5 11 5 decreased cochlear hair cell number 0.00260700765049389 0.0141747137280952 0.936632985100188 1 11.5 11 5 increased neuronal precursor cell number 0.00260700765049389 0.0141747137280952 0.936632985100188 1 11.5 11 5 liver hyperplasia 0.00260700765049389 0.0141747137280952 0.936632985100188 1 11.5 11 5 abnormal posterior eye segment morphology 0.00260700765049389 0.0141747137280952 0.936632985100188 1 11.5 11 5 positive geotaxis 0.00260700765049389 0.0141747137280952 0.936632985100188 1 11.5 11 5 enhanced conditioned place preference behavior 0.00260700765049389 0.0141747137280952 0.936632985100188 1 11.5 11 5 fusion of atlas and occipital bones 0.00260700765049389 0.0141747137280952 0.936632985100188 1 11.5 11 5 abnormal lung lobe morphology 0.00260700765049389 0.0141747137280952 0.936632985100188 1 11.5 11 5 abnormal infrahyoid muscle connection 0.00260700765049389 0.0141747137280952 0.936632985100188 1 11.5 11 5 increased cardiac muscle glycogen level 0.00260700765049389 0.0141747137280952 0.936632985100188 1 11.5 11 5 decreased fatty acid oxidation 0.00260700765049389 0.0141747137280952 0.936632985100188 1 11.5 11 5 cerebellum atrophy 0.00260700765049389 0.0141747137280952 0.936632985100188 1 11.5 11 5 decreased platelet dense granule number 0.00260700765049389 0.0141747137280952 0.936632985100188 1 11.5 11 5 increased sensitivity to skin irradiation 0.00504993269028218 0.0245825979786241 0.936632985100188 1 11.5 11 5 short ureter 0.00504993269028218 0.0245825979786241 0.936632985100188 1 11.5 11 5 hypospadia 0.00504993269028218 0.0245825979786241 0.936632985100188 1 11.5 11 5 early eyelid opening 0.00504993269028218 0.0245825979786241 0.936632985100188 1 11.5 11 5 abnormal eyelid aperture 0.00504993269028218 0.0245825979786241 0.936632985100188 1 11.5 11 5 binucleate 0.00504993269028218 0.0245825979786241 0.936632985100188 1 11.5 11 5 tau protein deposits 0.00504993269028218 0.0245825979786241 0.936632985100188 1 11.5 11 5 absent interparietal bone 0.00504993269028218 0.0245825979786241 0.936632985100188 1 11.5 11 5 abnormal kidney epithelium morphology 0.00504993269028218 0.0245825979786241 0.936632985100188 1 11.5 11 5 accumulation of giant lysosomes in kidney/renal tubule cells 0.00504993269028218 0.0245825979786241 0.936632985100188 1 11.5 11 5 ocular hypertension 0.00504993269028218 0.0245825979786241 0.936632985100188 1 11.5 11 5 craniofacial phenotype 0.00504993269028218 0.0245825979786241 0.936632985100188 1 11.5 11 5 stomach epithelial hyperplasia 0.00504993269028218 0.0245825979786241 0.936632985100188 1 11.5 11 5 abnormal frontonasal prominence morphology 0.00504993269028218 0.0245825979786241 0.936632985100188 1 11.5 11 5 abnormal cerebellum deep nucleus morphology 0.00504993269028218 0.0245825979786241 0.936632985100188 1 11.5 11 5 increased caudal vertebrae number 0.00504993269028218 0.0245825979786241 0.936632985100188 1 11.5 11 5 decreased quadriceps weight 0.00504993269028218 0.0245825979786241 0.936632985100188 1 11.5 11 5 delayed suture closure 0.00504993269028218 0.0245825979786241 0.936632985100188 1 11.5 11 5 lung situs inversus 0.00504993269028218 0.0245825979786241 0.936632985100188 1 11.5 11 5 abnormal bronchiole epithelium morphology 0.00504993269028218 0.0245825979786241 0.936632985100188 1 11.5 11 5 abnormal maxillary prominence morphology 0.00504993269028218 0.0245825979786241 0.936632985100188 1 11.5 11 5 increased aorta wall thickness 0.00504993269028218 0.0245825979786241 0.936632985100188 1 11.5 11 5 absent Reichert's membrane 0.00504993269028218 0.0245825979786241 0.936632985100188 1 11.5 11 5 abnormal umbilical vein topology 0.00504993269028218 0.0245825979786241 0.936632985100188 1 11.5 11 5 broad head 0.00978175711343805 0.0411362989343654 0.936632985100188 1 11.5 11 5 polyphalangy 0.00978175711343805 0.0411362989343654 0.936632985100188 1 11.5 11 5 maxilla hypoplasia 0.00978175711343805 0.0411362989343654 0.936632985100188 1 11.5 11 5 mammary gland hyperplasia 0.00978175711343805 0.0411362989343654 0.936632985100188 1 11.5 11 5 decreased Schwann cell number 0.00978175711343805 0.0411362989343654 0.936632985100188 1 11.5 11 5 skin photosensitivity 0.00978175711343805 0.0411362989343654 0.936632985100188 1 11.5 11 5 abnormal circulating alanine transaminase level 0.00978175711343805 0.0411362989343654 0.936632985100188 1 11.5 11 5 abnormal tumor incidence 0.00978175711343805 0.0411362989343654 0.936632985100188 1 11.5 11 5 abnormal brain ventricular system morphology 0.00978175711343805 0.0411362989343654 0.936632985100188 1 11.5 11 5 decreased mortality induced by ionizing radiation 0.00978175711343805 0.0411362989343654 0.936632985100188 1 11.5 11 5 decreased cardiomyocyte apoptosis 0.00978175711343805 0.0411362989343654 0.936632985100188 1 11.5 11 5 increased cell nucleus count 0.00978175711343805 0.0411362989343654 0.936632985100188 1 11.5 11 5 abnormal Purkinje cell innervation 0.00978175711343805 0.0411362989343654 0.936632985100188 1 11.5 11 5 renal necrosis 0.00978175711343805 0.0411362989343654 0.936632985100188 1 11.5 11 5 abnormal optic tract morphology 0.00978175711343805 0.0411362989343654 0.936632985100188 1 11.5 11 5 abnormal talus morphology 0.00978175711343805 0.0411362989343654 0.936632985100188 1 11.5 11 5 urolithiasis 0.00978175711343805 0.0411362989343654 0.936632985100188 1 11.5 11 5 absent fibula 0.00978175711343805 0.0411362989343654 0.936632985100188 1 11.5 11 5 abnormal renal filtration rate 0.00978175711343805 0.0411362989343654 0.936632985100188 1 11.5 11 5 increased keratinocyte apoptosis 0.00978175711343805 0.0411362989343654 0.936632985100188 1 11.5 11 5 uremia 0.00978175711343805 0.0411362989343654 0.936632985100188 1 11.5 11 5 postaxial polydactyly 0.00978175711343805 0.0411362989343654 0.936632985100188 1 11.5 11 5 decreased DN4 thymocyte number 0.00978175711343805 0.0411362989343654 0.936632985100188 1 11.5 11 5 increased oligodendrocyte number 0.00978175711343805 0.0411362989343654 0.936632985100188 1 11.5 11 5 decreased brain cholesterol level 0.00978175711343805 0.0411362989343654 0.936632985100188 1 11.5 11 5 abnormal retina inner limiting membrane morphology 0.00978175711343805 0.0411362989343654 0.936632985100188 1 11.5 11 5 coronary fistula 0.00978175711343805 0.0411362989343654 0.936632985100188 1 11.5 11 5 abnormal T wave 0.00978175711343805 0.0411362989343654 0.936632985100188 1 11.5 11 5 abnormal conotruncal ridge morphology 0.00978175711343805 0.0411362989343654 0.936632985100188 1 11.5 11 5 abnormal aortic valve cusp morphology 0.00978175711343805 0.0411362989343654 0.936632985100188 1 11.5 11 5 small lung saccule 0.00978175711343805 0.0411362989343654 0.936632985100188 1 11.5 11 5 dilated pulmonary alveolar ducts 0.00978175711343805 0.0411362989343654 0.936632985100188 1 11.5 11 5 small lung lobe 0.00978175711343805 0.0411362989343654 0.936632985100188 1 11.5 11 5 abnormal outer hair cell kinocilium morphology 0.00978175711343805 0.0411362989343654 0.936632985100188 1 11.5 11 5 ductus venosus stenosis 0.00978175711343805 0.0411362989343654 0.936632985100188 1 11.5 11 5 decreased hair follicle number 4.44675336940709e-10 1.24986429450849e-08 0.911984748650184 0.973684210526316 11.5 11 5 abnormal trigeminal nerve morphology 4.63347038284307e-07 7.50863685819032e-06 0.901942874540922 0.962962962962963 11.5 11 5 abnormal trigeminal ganglion morphology 4.63347038284307e-07 7.50863685819032e-06 0.901942874540922 0.962962962962963 11.5 11 5 increased thymocyte apoptosis 8.65935555583252e-07 1.29759921356225e-05 0.900608639519412 0.961538461538462 11.5 11 5 abnormal myocardial trabeculae morphology 1.07869467127434e-10 3.33323353390675e-09 0.895004852429069 0.955555555555556 11.5 11 5 abnormal amino acid level 2.00064291311776e-10 5.99590270648244e-09 0.894058758504725 0.954545454545455 11.5 11 5 abnormal circulating lipid level 1.04053576906039e-05 0.00011955347462068 0.894058758504725 0.954545454545455 11.5 11 5 abnormal hematopoietic system physiology 1.92878756160465e-05 0.000208675297633092 0.892031414381132 0.952380952380952 11.5 11 5 abnormal embryonic/fetal subventricular zone morphology 1.92878756160465e-05 0.000208675297633092 0.892031414381132 0.952380952380952 11.5 11 5 abnormal neural tube closure 2.06976944392488e-18 1.60892234117598e-16 0.891494046059215 0.951807228915663 11.5 11 5 increased mammary adenocarcinoma incidence 3.56785382347012e-05 0.000356427164091644 0.889801335845179 0.95 11.5 11 5 abnormal hyoid bone morphology 3.56785382347012e-05 0.000356427164091644 0.889801335845179 0.95 11.5 11 5 spleen atrophy 3.56785382347012e-05 0.000356427164091644 0.889801335845179 0.95 11.5 11 5 abnormal postnatal subventricular zone morphology 3.56785382347012e-05 0.000356427164091644 0.889801335845179 0.95 11.5 11 5 dilated vasculature 3.56785382347012e-05 0.000356427164091644 0.889801335845179 0.95 11.5 11 5 decreased circulating VLDL cholesterol level 3.56785382347012e-05 0.000356427164091644 0.889801335845179 0.95 11.5 11 5 absent ductus venosus valve 3.56785382347012e-05 0.000356427164091644 0.889801335845179 0.95 11.5 11 5 increased embryonic tissue cell apoptosis 4.43661749880586e-17 2.94295627420789e-15 0.88860052432582 0.948717948717949 11.5 11 5 decreased neuron apoptosis 7.95472032812811e-09 1.79885152874715e-07 0.887336512200179 0.947368421052632 11.5 11 5 abnormal nasal septum morphology 6.58473235453889e-05 0.000619263581546899 0.887336512200179 0.947368421052632 11.5 11 5 abnormal metatarsal bone morphology 6.58473235453889e-05 0.000619263581546899 0.887336512200179 0.947368421052632 11.5 11 5 decreased eye pigmentation 6.58473235453889e-05 0.000619263581546899 0.887336512200179 0.947368421052632 11.5 11 5 kidney cysts 5.0885285360629e-16 2.94365458917592e-14 0.886004175094773 0.945945945945946 11.5 11 5 abnormal head morphology 3.61763354552481e-12 1.38416876284798e-10 0.885543913185633 0.945454545454545 11.5 11 5 abnormal mitral valve morphology 0.000121220881401809 0.00103266076194178 0.884597819261289 0.944444444444444 11.5 11 5 underdeveloped hair follicles 0.000121220881401809 0.00103266076194178 0.884597819261289 0.944444444444444 11.5 11 5 delayed kidney development 0.000121220881401809 0.00103266076194178 0.884597819261289 0.944444444444444 11.5 11 5 decreased cellular sensitivity to gamma-irradiation 0.000121220881401809 0.00103266076194178 0.884597819261289 0.944444444444444 11.5 11 5 jerky movement 0.000121220881401809 0.00103266076194178 0.884597819261289 0.944444444444444 11.5 11 5 small thoracic cage 0.000121220881401809 0.00103266076194178 0.884597819261289 0.944444444444444 11.5 11 5 increased effector memory CD4-positive, alpha-beta T cell number 0.000121220881401809 0.00103266076194178 0.884597819261289 0.944444444444444 11.5 11 5 abnormal aerobic respiration 0.000121220881401809 0.00103266076194178 0.884597819261289 0.944444444444444 11.5 11 5 abnormal dorsal-ventral axis patterning 0.000222540264724527 0.00177142050720724 0.881536927153118 0.941176470588235 11.5 11 5 nephrocalcinosis 0.000222540264724527 0.00177142050720724 0.881536927153118 0.941176470588235 11.5 11 5 abnormal involuntary movement 0.000222540264724527 0.00177142050720724 0.881536927153118 0.941176470588235 11.5 11 5 coloboma 0.000222540264724527 0.00177142050720724 0.881536927153118 0.941176470588235 11.5 11 5 pancreatic islet hyperplasia 3.00921571719404e-07 5.16236144587598e-06 0.878093423531426 0.9375 11.5 11 5 increased fibroblast apoptosis 3.00921571719404e-07 5.16236144587598e-06 0.878093423531426 0.9375 11.5 11 5 absent mandible 0.00040728211367347 0.00300627376190729 0.878093423531426 0.9375 11.5 11 5 abnormal hair follicle orientation 0.00040728211367347 0.00300627376190729 0.878093423531426 0.9375 11.5 11 5 abnormal mouth morphology 0.00040728211367347 0.00300627376190729 0.878093423531426 0.9375 11.5 11 5 disorganized yolk sac vascular plexus 0.00040728211367347 0.00300627376190729 0.878093423531426 0.9375 11.5 11 5 intraventricular hemorrhage 0.00040728211367347 0.00300627376190729 0.878093423531426 0.9375 11.5 11 5 small pancreas 0.00040728211367347 0.00300627376190729 0.878093423531426 0.9375 11.5 11 5 decreased creatinine clearance 0.00040728211367347 0.00300627376190729 0.878093423531426 0.9375 11.5 11 5 kidney degeneration 0.00040728211367347 0.00300627376190729 0.878093423531426 0.9375 11.5 11 5 abnormal pulmonary alveolus wall morphology 0.00040728211367347 0.00300627376190729 0.878093423531426 0.9375 11.5 11 5 increased cellular sensitivity to gamma-irradiation 4.51696842643936e-10 1.26246729896269e-08 0.876847900944857 0.936170212765957 11.5 11 5 abnormal nose morphology 5.48007452762115e-07 8.57338703613686e-06 0.876205050577596 0.935483870967742 11.5 11 5 pale kidney 5.48007452762115e-07 8.57338703613686e-06 0.876205050577596 0.935483870967742 11.5 11 5 abnormal brain vasculature morphology 9.9595717086923e-07 1.46594287724095e-05 0.874190786093509 0.933333333333333 11.5 11 5 macrocytosis 0.000742808163537824 0.00490766349747765 0.874190786093509 0.933333333333333 11.5 11 5 interdigital webbing 0.000742808163537824 0.00490766349747765 0.874190786093509 0.933333333333333 11.5 11 5 abnormal cricoid cartilage morphology 0.000742808163537824 0.00490766349747765 0.874190786093509 0.933333333333333 11.5 11 5 delayed intramembranous bone ossification 0.000742808163537824 0.00490766349747765 0.874190786093509 0.933333333333333 11.5 11 5 abnormal trophectoderm morphology 0.000742808163537824 0.00490766349747765 0.874190786093509 0.933333333333333 11.5 11 5 abnormal olfactory nerve morphology 0.000742808163537824 0.00490766349747765 0.874190786093509 0.933333333333333 11.5 11 5 heterochrony 0.000742808163537824 0.00490766349747765 0.874190786093509 0.933333333333333 11.5 11 5 abnormal parietal bone morphology 1.80616989599717e-06 2.44850504047007e-05 0.872037606817417 0.931034482758621 11.5 11 5 decreased trophoblast giant cell number 1.80616989599717e-06 2.44850504047007e-05 0.872037606817417 0.931034482758621 11.5 11 5 abnormal outer ear morphology 1.80616989599717e-06 2.44850504047007e-05 0.872037606817417 0.931034482758621 11.5 11 5 increased triglyceride level 3.26796271672213e-06 4.20106318234951e-05 0.869730629021603 0.928571428571429 11.5 11 5 abnormal kidney blood vessel morphology 0.00134946165054233 0.00799234727553344 0.869730629021603 0.928571428571429 11.5 11 5 translucent skin 0.00134946165054233 0.00799234727553344 0.869730629021603 0.928571428571429 11.5 11 5 abnormal placing response 0.00134946165054233 0.00799234727553344 0.869730629021603 0.928571428571429 11.5 11 5 absent olfactory bulb 0.00134946165054233 0.00799234727553344 0.869730629021603 0.928571428571429 11.5 11 5 vascular smooth muscle hypoplasia 0.00134946165054233 0.00799234727553344 0.869730629021603 0.928571428571429 11.5 11 5 abnormal viscerocranium morphology 0.00134946165054233 0.00799234727553344 0.869730629021603 0.928571428571429 11.5 11 5 decreased tongue size 0.00134946165054233 0.00799234727553344 0.869730629021603 0.928571428571429 11.5 11 5 abnormal renal reabsorbtion 0.00134946165054233 0.00799234727553344 0.869730629021603 0.928571428571429 11.5 11 5 palatal shelves fail to meet at midline 1.59408295038622e-08 3.44807072963976e-07 0.868098864239199 0.926829268292683 11.5 11 5 abnormal maxilla morphology 8.13756330414689e-11 2.59515239988018e-09 0.867252763981656 0.925925925925926 11.5 11 5 abnormal Mullerian duct morphology 1.06176544998749e-05 0.000121153282424031 0.864584293938635 0.923076923076923 11.5 11 5 absent common myeloid progenitor cells 0.00244070520004327 0.0135670484583411 0.864584293938635 0.923076923076923 11.5 11 5 absent myocardial trabeculae 0.00244070520004327 0.0135670484583411 0.864584293938635 0.923076923076923 11.5 11 5 abnormal tail bud morphology 0.00244070520004327 0.0135670484583411 0.864584293938635 0.923076923076923 11.5 11 5 abnormal coping response 0.00244070520004327 0.0135670484583411 0.864584293938635 0.923076923076923 11.5 11 5 anal atresia 0.00244070520004327 0.0135670484583411 0.864584293938635 0.923076923076923 11.5 11 5 abnormal telomere length 0.00244070520004327 0.0135670484583411 0.864584293938635 0.923076923076923 11.5 11 5 absent hypoglossal nerve 0.00244070520004327 0.0135670484583411 0.864584293938635 0.923076923076923 11.5 11 5 abnormal vitelline vasculature morphology 3.6789008202731e-21 3.97881121323015e-19 0.863331273222782 0.921739130434783 11.5 11 5 abnormal cell morphology 6.59047474023072e-21 6.6913493536016e-19 0.862688275750173 0.921052631578947 11.5 11 5 short stride length 8.43797024821508e-10 2.22779889886244e-08 0.861702346292173 0.92 11.5 11 5 abnormal egg cylinder morphology 1.90588932163283e-05 0.000208391195057655 0.861702346292173 0.92 11.5 11 5 diaphragmatic hernia 1.90588932163283e-05 0.000208391195057655 0.861702346292173 0.92 11.5 11 5 abnormal hepatocyte morphology 3.77156806292436e-20 3.35063412733012e-18 0.860689770092065 0.918918918918919 11.5 11 5 malocclusion 1.65608089510594e-07 2.91130828733288e-06 0.860689770092065 0.918918918918919 11.5 11 5 abnormal lung saccule morphology 3.41064832219944e-05 0.000349135296356835 0.858580236341839 0.916666666666667 11.5 11 5 abnormal glossopharyngeal nerve morphology 0.00439195672736805 0.0221377758041095 0.858580236341839 0.916666666666667 11.5 11 5 absent optic nerve 0.00439195672736805 0.0221377758041095 0.858580236341839 0.916666666666667 11.5 11 5 abnormal embryonic growth/weight/body size 0.00439195672736805 0.0221377758041095 0.858580236341839 0.916666666666667 11.5 11 5 abnormal respiratory function 0.00439195672736805 0.0221377758041095 0.858580236341839 0.916666666666667 11.5 11 5 decreased synaptic depression 0.00439195672736805 0.0221377758041095 0.858580236341839 0.916666666666667 11.5 11 5 abnormal alisphenoid bone morphology 0.00439195672736805 0.0221377758041095 0.858580236341839 0.916666666666667 11.5 11 5 loss of dopaminergic neurons 0.00439195672736805 0.0221377758041095 0.858580236341839 0.916666666666667 11.5 11 5 abnormal vascular endothelial cell development 0.00439195672736805 0.0221377758041095 0.858580236341839 0.916666666666667 11.5 11 5 absent ovary 0.00439195672736805 0.0221377758041095 0.858580236341839 0.916666666666667 11.5 11 5 hematuria 0.00439195672736805 0.0221377758041095 0.858580236341839 0.916666666666667 11.5 11 5 decreased renal glomerular filtration rate 0.00439195672736805 0.0221377758041095 0.858580236341839 0.916666666666667 11.5 11 5 reduced cerebellar foliation 0.00439195672736805 0.0221377758041095 0.858580236341839 0.916666666666667 11.5 11 5 decreased mammary gland epithelial cell proliferation 0.00439195672736805 0.0221377758041095 0.858580236341839 0.916666666666667 11.5 11 5 increased skeletal muscle glycogen level 0.00439195672736805 0.0221377758041095 0.858580236341839 0.916666666666667 11.5 11 5 abnormal pulmonary valve cusp morphology 0.00439195672736805 0.0221377758041095 0.858580236341839 0.916666666666667 11.5 11 5 lethality throughout fetal growth and development, complete penetrance 5.75515151055072e-33 1.98148307000719e-30 0.857758628460173 0.91578947368421 11.5 11 5 abnormal liver development 5.27027376218801e-07 8.35019489391253e-06 0.856350157805886 0.914285714285714 11.5 11 5 abnormal dermal layer morphology 5.27027376218801e-07 8.35019489391253e-06 0.856350157805886 0.914285714285714 11.5 11 5 decreased triglyceride level 5.27027376218801e-07 8.35019489391253e-06 0.856350157805886 0.914285714285714 11.5 11 5 decreased glycogen level 5.27027376218801e-07 8.35019489391253e-06 0.856350157805886 0.914285714285714 11.5 11 5 decreased cell proliferation 1.02989854679269e-31 2.69670803699666e-29 0.855626889091523 0.913513513513514 11.5 11 5 abnormal pulmonary artery morphology 6.08328126359219e-05 0.000576463319740403 0.855186638569737 0.91304347826087 11.5 11 5 bidirectional circling 6.08328126359219e-05 0.000576463319740403 0.855186638569737 0.91304347826087 11.5 11 5 abnormal nasal cavity morphology 6.08328126359219e-05 0.000576463319740403 0.855186638569737 0.91304347826087 11.5 11 5 incomplete embryo turning 1.41320884295064e-10 4.33994690967865e-09 0.854472196933505 0.912280701754386 11.5 11 5 pericardial edema 2.38087960957514e-12 9.32667406113097e-11 0.853988898179584 0.911764705882353 11.5 11 5 abnormal brown adipose tissue morphology 9.36795929911997e-07 1.38295541581964e-05 0.853988898179584 0.911764705882353 11.5 11 5 abnormal nervous system development 9.36795929911997e-07 1.38295541581964e-05 0.853988898179584 0.911764705882353 11.5 11 5 enlarged pericardium 1.66086110912839e-06 2.28885983875727e-05 0.851484531909262 0.909090909090909 11.5 11 5 abnormal locomotor coordination 1.66086110912839e-06 2.28885983875727e-05 0.851484531909262 0.909090909090909 11.5 11 5 abnormal facial nerve morphology 0.000108113054870472 0.000951968934478938 0.851484531909262 0.909090909090909 11.5 11 5 abnormal tail movements 0.000108113054870472 0.000951968934478938 0.851484531909262 0.909090909090909 11.5 11 5 abnormal lysosome physiology 0.000108113054870472 0.000951968934478938 0.851484531909262 0.909090909090909 11.5 11 5 abnormal vascular branching morphogenesis 0.000108113054870472 0.000951968934478938 0.851484531909262 0.909090909090909 11.5 11 5 prolonged PR interval 0.000108113054870472 0.000951968934478938 0.851484531909262 0.909090909090909 11.5 11 5 abnormal occipital bone morphology 0.000108113054870472 0.000951968934478938 0.851484531909262 0.909090909090909 11.5 11 5 increased adenoma incidence 0.000108113054870472 0.000951968934478938 0.851484531909262 0.909090909090909 11.5 11 5 premature suture closure 0.00785666255808821 0.0355335420240807 0.851484531909262 0.909090909090909 11.5 11 5 abnormal thrombopoiesis 0.00785666255808821 0.0355335420240807 0.851484531909262 0.909090909090909 11.5 11 5 abnormal awl hair morphology 0.00785666255808821 0.0355335420240807 0.851484531909262 0.909090909090909 11.5 11 5 abnormal glossopharyngeal ganglion morphology 0.00785666255808821 0.0355335420240807 0.851484531909262 0.909090909090909 11.5 11 5 abnormal food preference 0.00785666255808821 0.0355335420240807 0.851484531909262 0.909090909090909 11.5 11 5 focal hepatic necrosis 0.00785666255808821 0.0355335420240807 0.851484531909262 0.909090909090909 11.5 11 5 failure of somite differentiation 0.00785666255808821 0.0355335420240807 0.851484531909262 0.909090909090909 11.5 11 5 abnormal proximal-distal axis patterning 0.00785666255808821 0.0355335420240807 0.851484531909262 0.909090909090909 11.5 11 5 abnormal fear/anxiety-related behavior 0.00785666255808821 0.0355335420240807 0.851484531909262 0.909090909090909 11.5 11 5 abnormal bronchiole morphology 0.00785666255808821 0.0355335420240807 0.851484531909262 0.909090909090909 11.5 11 5 fatigue 0.00785666255808821 0.0355335420240807 0.851484531909262 0.909090909090909 11.5 11 5 loss of cortex neurons 0.00785666255808821 0.0355335420240807 0.851484531909262 0.909090909090909 11.5 11 5 abnormal radial glial cell morphology 0.00785666255808821 0.0355335420240807 0.851484531909262 0.909090909090909 11.5 11 5 abnormal coronal suture morphology 0.00785666255808821 0.0355335420240807 0.851484531909262 0.909090909090909 11.5 11 5 abnormal spinal cord ventral horn morphology 0.00785666255808821 0.0355335420240807 0.851484531909262 0.909090909090909 11.5 11 5 abnormal superovulation 0.00785666255808821 0.0355335420240807 0.851484531909262 0.909090909090909 11.5 11 5 abnormal palate development 0.00785666255808821 0.0355335420240807 0.851484531909262 0.909090909090909 11.5 11 5 palatal shelf hypoplasia 0.00785666255808821 0.0355335420240807 0.851484531909262 0.909090909090909 11.5 11 5 abnormal brain ependyma motile cilium morphology 0.00785666255808821 0.0355335420240807 0.851484531909262 0.909090909090909 11.5 11 5 abnormal embryo turning 4.43312603839605e-10 1.24986429450849e-08 0.851484531909262 0.909090909090909 11.5 11 5 atrioventricular septal defect 1.38107236593295e-09 3.54166753634867e-08 0.848271382732246 0.905660377358491 11.5 11 5 embryonic lethality at implantation, complete penetrance 0.00019138983311192 0.00155582421524805 0.847429843662075 0.904761904761905 11.5 11 5 abnormal cell cycle 3.38124976108481e-19 2.75765861662244e-17 0.847042003916692 0.904347826086957 11.5 11 5 pale yolk sac 3.7001608454405e-14 1.84083002060665e-12 0.846355107018243 0.903614457831325 11.5 11 5 abnormal postnatal growth/weight/body size 5.17682120653561e-06 6.312422917283e-05 0.845991083316299 0.903225806451613 11.5 11 5 preaxial polydactyly 5.17682120653561e-06 6.312422917283e-05 0.845991083316299 0.903225806451613 11.5 11 5 abnormal craniofacial morphology 3.41817478018704e-17 2.3618638238098e-15 0.845697743828325 0.902912621359223 11.5 11 5 abnormal forebrain development 2.15442846046242e-12 8.50657269111155e-11 0.845571444882114 0.902777777777778 11.5 11 5 abnormal cell differentiation 1.46749888759589e-07 2.61677669024716e-06 0.845254157285536 0.902439024390244 11.5 11 5 liver hemorrhage 9.09808442214865e-06 0.00010550808857853 0.84296968659017 0.9 11.5 11 5 abnormal cell proliferation 0.000337366391341579 0.00256635748765192 0.84296968659017 0.9 11.5 11 5 abnormal vascular regression 0.000337366391341579 0.00256635748765192 0.84296968659017 0.9 11.5 11 5 abnormal incus morphology 0.000337366391341579 0.00256635748765192 0.84296968659017 0.9 11.5 11 5 abnormal otic capsule morphology 0.013957695272339 0.0558195610770793 0.84296968659017 0.9 11.5 11 5 abnormal auchene hair morphology 0.013957695272339 0.0558195610770793 0.84296968659017 0.9 11.5 11 5 jaundice 0.013957695272339 0.0558195610770793 0.84296968659017 0.9 11.5 11 5 abnormal mammary gland physiology 0.013957695272339 0.0558195610770793 0.84296968659017 0.9 11.5 11 5 decreased incidence of induced tumors 0.013957695272339 0.0558195610770793 0.84296968659017 0.9 11.5 11 5 abnormal gland morphology 0.013957695272339 0.0558195610770793 0.84296968659017 0.9 11.5 11 5 ketoaciduria 0.013957695272339 0.0558195610770793 0.84296968659017 0.9 11.5 11 5 acrania 0.013957695272339 0.0558195610770793 0.84296968659017 0.9 11.5 11 5 aneurysm 0.013957695272339 0.0558195610770793 0.84296968659017 0.9 11.5 11 5 intestinal edema 0.013957695272339 0.0558195610770793 0.84296968659017 0.9 11.5 11 5 peritoneal inflammation 0.013957695272339 0.0558195610770793 0.84296968659017 0.9 11.5 11 5 abnormal hypaxial muscle morphology 0.013957695272339 0.0558195610770793 0.84296968659017 0.9 11.5 11 5 bifid ureter 0.013957695272339 0.0558195610770793 0.84296968659017 0.9 11.5 11 5 absent seminal vesicle 0.013957695272339 0.0558195610770793 0.84296968659017 0.9 11.5 11 5 abnormal glial cell physiology 0.013957695272339 0.0558195610770793 0.84296968659017 0.9 11.5 11 5 increased atrioventricular cushion size 0.013957695272339 0.0558195610770793 0.84296968659017 0.9 11.5 11 5 absent pharyngeal arches 0.013957695272339 0.0558195610770793 0.84296968659017 0.9 11.5 11 5 abnormal ear physiology 0.013957695272339 0.0558195610770793 0.84296968659017 0.9 11.5 11 5 abnormal reproductive system development 0.013957695272339 0.0558195610770793 0.84296968659017 0.9 11.5 11 5 abnormal embryonic erythrocyte morphology 0.013957695272339 0.0558195610770793 0.84296968659017 0.9 11.5 11 5 tachypnea 0.013957695272339 0.0558195610770793 0.84296968659017 0.9 11.5 11 5 abnormal developmental vascular remodeling 0.013957695272339 0.0558195610770793 0.84296968659017 0.9 11.5 11 5 decreased transitional stage T2 B cell number 0.013957695272339 0.0558195610770793 0.84296968659017 0.9 11.5 11 5 increased serotonin level 0.013957695272339 0.0558195610770793 0.84296968659017 0.9 11.5 11 5 abnormal retinal blood vessel pattern 0.013957695272339 0.0558195610770793 0.84296968659017 0.9 11.5 11 5 aorta stenosis 0.013957695272339 0.0558195610770793 0.84296968659017 0.9 11.5 11 5 abnormal inferior vena cava valve morphology 0.013957695272339 0.0558195610770793 0.84296968659017 0.9 11.5 11 5 fusion of atlas and odontoid process 0.013957695272339 0.0558195610770793 0.84296968659017 0.9 11.5 11 5 increased compact bone area 0.013957695272339 0.0558195610770793 0.84296968659017 0.9 11.5 11 5 abnormal adaptive thermogenesis 0.013957695272339 0.0558195610770793 0.84296968659017 0.9 11.5 11 5 decreased macrophage apoptosis 0.013957695272339 0.0558195610770793 0.84296968659017 0.9 11.5 11 5 anophthalmia 1.05818719885244e-14 5.48383470238637e-13 0.841917289977697 0.898876404494382 11.5 11 5 abnormal craniofacial development 1.31006786535489e-08 2.87118397803549e-07 0.84105819070221 0.897959183673469 11.5 11 5 increased hepatocyte apoptosis 4.50740454200555e-07 7.4499460453414e-06 0.840568063551451 0.897435897435897 11.5 11 5 increased mortality induced by gamma-irradiation 1.59368338296718e-05 0.000176144017084688 0.839739917676031 0.896551724137931 11.5 11 5 embryonic lethality before implantation, complete penetrance 8.57495069474784e-20 7.23057283158822e-18 0.839223154649769 0.896 11.5 11 5 vertebral transformation 2.28716535586098e-08 4.78094438882705e-07 0.839067049152252 0.895833333333333 11.5 11 5 thymus atrophy 2.28716535586098e-08 4.78094438882705e-07 0.839067049152252 0.895833333333333 11.5 11 5 abnormal erythropoiesis 9.11776046195318e-17 5.81549465361757e-15 0.838509529518264 0.895238095238095 11.5 11 5 persistence of hyaloid vascular system 7.86829020536967e-07 1.19708696549584e-05 0.838040039300169 0.894736842105263 11.5 11 5 impaired branching involved in ureteric bud morphogenesis 7.86829020536967e-07 1.19708696549584e-05 0.838040039300169 0.894736842105263 11.5 11 5 abnormal triglyceride level 0.000591896123181379 0.00407850860502404 0.838040039300169 0.894736842105263 11.5 11 5 unresponsive to tactile stimuli 0.000591896123181379 0.00407850860502404 0.838040039300169 0.894736842105263 11.5 11 5 abnormal optic vesicle formation 0.000591896123181379 0.00407850860502404 0.838040039300169 0.894736842105263 11.5 11 5 increased left ventricle weight 0.000591896123181379 0.00407850860502404 0.838040039300169 0.894736842105263 11.5 11 5 abnormal sternebra morphology 0.000591896123181379 0.00407850860502404 0.838040039300169 0.894736842105263 11.5 11 5 abnormal blastocyst morphology 0.000591896123181379 0.00407850860502404 0.838040039300169 0.894736842105263 11.5 11 5 increased liver cholesterol level 0.000591896123181379 0.00407850860502404 0.838040039300169 0.894736842105263 11.5 11 5 embryonic lethality between implantation and somite formation, incomplete penetrance 0.000591896123181379 0.00407850860502404 0.838040039300169 0.894736842105263 11.5 11 5 decreased brain weight 1.17858723936427e-09 3.0698803747839e-08 0.838040039300168 0.894736842105263 11.5 11 5 abnormal lung development 9.78058138552319e-14 4.59041437669603e-12 0.837460080795463 0.894117647058824 11.5 11 5 abnormal embryo size 8.46162353791875e-18 6.37826925774936e-16 0.837167535355036 0.893805309734513 11.5 11 5 myoclonus 2.78177028976358e-05 0.000289525255053845 0.836279450982311 0.892857142857143 11.5 11 5 abnormal somite shape 2.78177028976358e-05 0.000289525255053845 0.836279450982311 0.892857142857143 11.5 11 5 premature aging 2.78177028976358e-05 0.000289525255053845 0.836279450982311 0.892857142857143 11.5 11 5 hypoxia 2.78177028976358e-05 0.000289525255053845 0.836279450982311 0.892857142857143 11.5 11 5 abnormal brainstem morphology 2.78177028976358e-05 0.000289525255053845 0.836279450982311 0.892857142857143 11.5 11 5 prolonged QRS complex duration 2.78177028976358e-05 0.000289525255053845 0.836279450982311 0.892857142857143 11.5 11 5 subcutaneous edema 2.78177028976358e-05 0.000289525255053845 0.836279450982311 0.892857142857143 11.5 11 5 lethargy 9.00734879862156e-15 4.76718726310024e-13 0.835919760895867 0.89247311827957 11.5 11 5 abnormal extraembryonic tissue morphology 4.78856509856268e-16 2.83608468635111e-14 0.83562354553056 0.892156862745098 11.5 11 5 increased circulating phosphate level 1.36964113055902e-06 1.92484876399184e-05 0.835375365089357 0.891891891891892 11.5 11 5 abnormal cell death 6.92337302498984e-08 1.31968508809672e-06 0.834825051937124 0.891304347826087 11.5 11 5 abnormal embryonic tissue morphology 2.08837711625014e-22 2.66401952649858e-20 0.834686537742345 0.891156462585034 11.5 11 5 decreased circulating total protein level 3.55859923011535e-09 8.27291176159993e-08 0.834454841271077 0.890909090909091 11.5 11 5 abnormal neural tube morphology 3.11594100424999e-24 4.55935485180696e-22 0.83256265342239 0.888888888888889 11.5 11 5 hydrops fetalis 1.67818442922865e-11 5.92125357121458e-10 0.83256265342239 0.888888888888889 11.5 11 5 abnormal chondrocyte morphology 6.16435486156627e-09 1.41325647171853e-07 0.83256265342239 0.888888888888889 11.5 11 5 heart right ventricle hypertrophy 2.37705579654527e-06 3.14517356058849e-05 0.83256265342239 0.888888888888889 11.5 11 5 abnormal pharyngeal arch morphology 2.37705579654527e-06 3.14517356058849e-05 0.83256265342239 0.888888888888889 11.5 11 5 abnormal trophoblast giant cell morphology 2.37705579654527e-06 3.14517356058849e-05 0.83256265342239 0.888888888888889 11.5 11 5 abnormal lysosome morphology 2.37705579654527e-06 3.14517356058849e-05 0.83256265342239 0.888888888888889 11.5 11 5 abnormal retinal blood vessel morphology 2.37705579654527e-06 3.14517356058849e-05 0.83256265342239 0.888888888888889 11.5 11 5 abnormal atrioventricular cushion morphology 4.83725543243141e-05 0.000473727279061934 0.83256265342239 0.888888888888889 11.5 11 5 abnormal skin appearance 4.83725543243141e-05 0.000473727279061934 0.83256265342239 0.888888888888889 11.5 11 5 decreased circulating fructosamine level 4.83725543243141e-05 0.000473727279061934 0.83256265342239 0.888888888888889 11.5 11 5 decreased bone ossification 4.83725543243141e-05 0.000473727279061934 0.83256265342239 0.888888888888889 11.5 11 5 abnormal megakaryocyte differentiation 0.00103309533130628 0.00651413089131651 0.83256265342239 0.888888888888889 11.5 11 5 cortical renal glomerulopathies 0.00103309533130628 0.00651413089131651 0.83256265342239 0.888888888888889 11.5 11 5 abnormal bile duct morphology 0.00103309533130628 0.00651413089131651 0.83256265342239 0.888888888888889 11.5 11 5 absent inner cell mass 0.00103309533130628 0.00651413089131651 0.83256265342239 0.888888888888889 11.5 11 5 abnormal anterior eye segment morphology 0.00103309533130628 0.00651413089131651 0.83256265342239 0.888888888888889 11.5 11 5 abnormal eye anterior chamber morphology 0.00103309533130628 0.00651413089131651 0.83256265342239 0.888888888888889 11.5 11 5 darkened coat color 0.00103309533130628 0.00651413089131651 0.83256265342239 0.888888888888889 11.5 11 5 decreased lactate dehydrogenase level 0.00103309533130628 0.00651413089131651 0.83256265342239 0.888888888888889 11.5 11 5 atrioventricular block 0.00103309533130628 0.00651413089131651 0.83256265342239 0.888888888888889 11.5 11 5 abnormal metanephric mesenchyme morphology 0.00103309533130628 0.00651413089131651 0.83256265342239 0.888888888888889 11.5 11 5 increased adipocyte glucose uptake 0.00103309533130628 0.00651413089131651 0.83256265342239 0.888888888888889 11.5 11 5 heart hyperplasia 0.0245933330085885 0.0862847896457881 0.83256265342239 0.888888888888889 11.5 11 5 distorted hair follicle pattern 0.0245933330085885 0.0862847896457881 0.83256265342239 0.888888888888889 11.5 11 5 abnormal cholinergic neuron morphology 0.0245933330085885 0.0862847896457881 0.83256265342239 0.888888888888889 11.5 11 5 abnormal ion homeostasis 0.0245933330085885 0.0862847896457881 0.83256265342239 0.888888888888889 11.5 11 5 decreased level of surface class I molecules 0.0245933330085885 0.0862847896457881 0.83256265342239 0.888888888888889 11.5 11 5 increased pheochromocytoma incidence 0.0245933330085885 0.0862847896457881 0.83256265342239 0.888888888888889 11.5 11 5 abnormal vomeronasal organ morphology 0.0245933330085885 0.0862847896457881 0.83256265342239 0.888888888888889 11.5 11 5 abnormal posterior semicircular canal morphology 0.0245933330085885 0.0862847896457881 0.83256265342239 0.888888888888889 11.5 11 5 abnormal NMDA-mediated synaptic currents 0.0245933330085885 0.0862847896457881 0.83256265342239 0.888888888888889 11.5 11 5 abnormal postural reflex 0.0245933330085885 0.0862847896457881 0.83256265342239 0.888888888888889 11.5 11 5 genetic imprinting 0.0245933330085885 0.0862847896457881 0.83256265342239 0.888888888888889 11.5 11 5 biliary cyst 0.0245933330085885 0.0862847896457881 0.83256265342239 0.888888888888889 11.5 11 5 pancreas cysts 0.0245933330085885 0.0862847896457881 0.83256265342239 0.888888888888889 11.5 11 5 abnormal artery development 0.0245933330085885 0.0862847896457881 0.83256265342239 0.888888888888889 11.5 11 5 abnormal thymus physiology 0.0245933330085885 0.0862847896457881 0.83256265342239 0.888888888888889 11.5 11 5 decreased cellular sensitivity to ionizing radiation 0.0245933330085885 0.0862847896457881 0.83256265342239 0.888888888888889 11.5 11 5 decreased muscle weight 0.0245933330085885 0.0862847896457881 0.83256265342239 0.888888888888889 11.5 11 5 hemothorax 0.0245933330085885 0.0862847896457881 0.83256265342239 0.888888888888889 11.5 11 5 absent adrenal gland 0.0245933330085885 0.0862847896457881 0.83256265342239 0.888888888888889 11.5 11 5 abnormal inguinal fat pad morphology 0.0245933330085885 0.0862847896457881 0.83256265342239 0.888888888888889 11.5 11 5 abnormal optic chiasm morphology 0.0245933330085885 0.0862847896457881 0.83256265342239 0.888888888888889 11.5 11 5 abnormal liver vasculature morphology 0.0245933330085885 0.0862847896457881 0.83256265342239 0.888888888888889 11.5 11 5 multiflagellated sperm 0.0245933330085885 0.0862847896457881 0.83256265342239 0.888888888888889 11.5 11 5 eye opacity 0.0245933330085885 0.0862847896457881 0.83256265342239 0.888888888888889 11.5 11 5 decreased transitional stage T1 B cell number 0.0245933330085885 0.0862847896457881 0.83256265342239 0.888888888888889 11.5 11 5 abnormal cerebellar layer morphology 0.0245933330085885 0.0862847896457881 0.83256265342239 0.888888888888889 11.5 11 5 axonal spheroids 0.0245933330085885 0.0862847896457881 0.83256265342239 0.888888888888889 11.5 11 5 abnormal telomere morphology 0.0245933330085885 0.0862847896457881 0.83256265342239 0.888888888888889 11.5 11 5 retropulsion 0.0245933330085885 0.0862847896457881 0.83256265342239 0.888888888888889 11.5 11 5 prolonged RR interval 0.0245933330085885 0.0862847896457881 0.83256265342239 0.888888888888889 11.5 11 5 iris coloboma 0.0245933330085885 0.0862847896457881 0.83256265342239 0.888888888888889 11.5 11 5 decreased effector memory CD4-positive, alpha-beta T cell number 0.0245933330085885 0.0862847896457881 0.83256265342239 0.888888888888889 11.5 11 5 abnormal pulmonary alveolar system morphology 0.0245933330085885 0.0862847896457881 0.83256265342239 0.888888888888889 11.5 11 5 abnormal oxidative phosphorylation 0.0245933330085885 0.0862847896457881 0.83256265342239 0.888888888888889 11.5 11 5 symmetric azygos veins 0.0245933330085885 0.0862847896457881 0.83256265342239 0.888888888888889 11.5 11 5 lethality throughout fetal growth and development, incomplete penetrance 1.54950104434395e-26 2.48669925664875e-24 0.831981254921397 0.888268156424581 11.5 11 5 double outlet right ventricle 2.29095021567366e-16 1.42468466537206e-14 0.831590033500167 0.88785046728972 11.5 11 5 polydactyly 4.30021674177135e-15 2.3509426692651e-13 0.831500711262412 0.887755102040816 11.5 11 5 pericardial effusion 5.53538173747095e-10 1.53016002633942e-08 0.830884099685651 0.887096774193548 11.5 11 5 abnormal mesoderm development 1.0654945371634e-08 2.35592680995018e-07 0.830599062258658 0.886792452830189 11.5 11 5 domed cranium 5.00211933799837e-11 1.67017071855986e-09 0.829589215374453 0.885714285714286 11.5 11 5 thick pulmonary interalveolar septum 4.11250222103427e-06 5.19281689077296e-05 0.829589215374453 0.885714285714286 11.5 11 5 abnormal artery morphology 4.11250222103427e-06 5.19281689077296e-05 0.829589215374453 0.885714285714286 11.5 11 5 increased circulating serum albumin level 4.11250222103427e-06 5.19281689077296e-05 0.829589215374453 0.885714285714286 11.5 11 5 abnormal embryonic epiblast morphology 4.11250222103427e-06 5.19281689077296e-05 0.829589215374453 0.885714285714286 11.5 11 5 decreased bone mineralization 4.11250222103427e-06 5.19281689077296e-05 0.829589215374453 0.885714285714286 11.5 11 5 preweaning lethality, complete penetrance 3.46414344425669e-104 8.61705681758852e-101 0.82904676383868 0.885135135135135 11.5 11 5 small liver 4.54208738864913e-12 1.68633468347235e-10 0.828559948357859 0.884615384615385 11.5 11 5 absent gastric milk in neonates 4.54208738864913e-12 1.68633468347235e-10 0.828559948357859 0.884615384615385 11.5 11 5 liver hypoplasia 1.83752724093509e-08 3.94038707916037e-07 0.828559948357859 0.884615384615385 11.5 11 5 abnormal placenta vasculature 1.83752724093509e-08 3.94038707916037e-07 0.828559948357859 0.884615384615385 11.5 11 5 ventricular hypoplasia 8.37750567091371e-05 0.000763334994739848 0.828559948357859 0.884615384615385 11.5 11 5 thick skin 8.37750567091371e-05 0.000763334994739848 0.828559948357859 0.884615384615385 11.5 11 5 increased leukemia incidence 8.37750567091371e-05 0.000763334994739848 0.828559948357859 0.884615384615385 11.5 11 5 microcephaly 8.61335553192212e-11 2.71211669438687e-09 0.82803785639292 0.884057971014493 11.5 11 5 kidney failure 3.57853882045468e-07 5.95425773637525e-06 0.827722172879236 0.883720930232558 11.5 11 5 abnormal double-strand DNA break repair 3.57853882045468e-07 5.95425773637525e-06 0.827722172879236 0.883720930232558 11.5 11 5 abnormal kidney development 1.6433606957191e-09 4.12915124303157e-08 0.8273591368385 0.883333333333333 11.5 11 5 decreased embryo size 1.61589399734983e-66 1.14843894811649e-63 0.826901924084267 0.882845188284519 11.5 11 5 abnormal blood vessel morphology 4.53079964738326e-21 4.79589962675143e-19 0.826820842019477 0.882758620689655 11.5 11 5 enlarged liver sinusoidal spaces 7.09134995325134e-06 8.37992066922219e-05 0.826440869206049 0.882352941176471 11.5 11 5 abnormal spleen red pulp morphology 7.09134995325134e-06 8.37992066922219e-05 0.826440869206049 0.882352941176471 11.5 11 5 abnormal bone marrow cavity morphology 0.00179284598079055 0.0104320570227286 0.826440869206049 0.882352941176471 11.5 11 5 abnormal interatrial septum morphology 0.00179284598079055 0.0104320570227286 0.826440869206049 0.882352941176471 11.5 11 5 abnormal embryonic-extraembryonic boundary morphology 0.00179284598079055 0.0104320570227286 0.826440869206049 0.882352941176471 11.5 11 5 abnormal tarsal bone morphology 0.00179284598079055 0.0104320570227286 0.826440869206049 0.882352941176471 11.5 11 5 increased brain size 0.00179284598079055 0.0104320570227286 0.826440869206049 0.882352941176471 11.5 11 5 enhanced behavioral response to cocaine 0.00179284598079055 0.0104320570227286 0.826440869206049 0.882352941176471 11.5 11 5 increased circulating magnesium level 0.00179284598079055 0.0104320570227286 0.826440869206049 0.882352941176471 11.5 11 5 increased trabecular bone mass 0.00179284598079055 0.0104320570227286 0.826440869206049 0.882352941176471 11.5 11 5 decreased body fat mass 0.00179284598079055 0.0104320570227286 0.826440869206049 0.882352941176471 11.5 11 5 abnormal cell cytoskeleton morphology 0.00179284598079055 0.0104320570227286 0.826440869206049 0.882352941176471 11.5 11 5 small lung 3.16152852225899e-08 6.58100602436756e-07 0.826440869206049 0.882352941176471 11.5 11 5 disheveled coat 6.15359261967113e-07 9.50749170275276e-06 0.825129058302547 0.880952380952381 11.5 11 5 skin edema 6.15359261967113e-07 9.50749170275276e-06 0.825129058302547 0.880952380952381 11.5 11 5 abnormal pancreas morphology 6.15359261967113e-07 9.50749170275276e-06 0.825129058302547 0.880952380952381 11.5 11 5 spina bifida 6.15359261967113e-07 9.50749170275276e-06 0.825129058302547 0.880952380952381 11.5 11 5 hemorrhage 6.37260886836484e-33 1.98148307000719e-30 0.82503416134357 0.880851063829787 11.5 11 5 abnormal liver physiology 1.01899979438172e-14 5.33634102847267e-13 0.824237026888166 0.88 11.5 11 5 abnormal hindlimb morphology 5.42626110474511e-08 1.06702169945087e-06 0.824237026888166 0.88 11.5 11 5 increased B cell derived lymphoma incidence 5.42626110474511e-08 1.06702169945087e-06 0.824237026888166 0.88 11.5 11 5 abnormal thyroid gland morphology 0.000144455476596879 0.00120241105597258 0.824237026888166 0.88 11.5 11 5 spontaneous skin ulceration 0.000144455476596879 0.00120241105597258 0.824237026888166 0.88 11.5 11 5 increased cellular sensitivity to ionizing radiation 0.000144455476596879 0.00120241105597258 0.824237026888166 0.88 11.5 11 5 thick ventricular wall 1.05504411634328e-06 1.530275358253e-05 0.822409450331873 0.878048780487805 11.5 11 5 liver fibrosis 1.05504411634328e-06 1.530275358253e-05 0.822409450331873 0.878048780487805 11.5 11 5 oxidative stress 3.25776362075626e-13 1.40933687071847e-11 0.82215562025461 0.877777777777778 11.5 11 5 abnormal circulating amino acid level 8.2746007829771e-09 1.8627212169824e-07 0.821607881666832 0.87719298245614 11.5 11 5 abnormal fertility/fecundity 6.71711188549893e-11 2.15597623421659e-09 0.821157685567288 0.876712328767123 11.5 11 5 abnormal brain morphology 2.61130504543899e-22 3.16859575635585e-20 0.820281061485258 0.875776397515528 11.5 11 5 abnormal urine homeostasis 8.65908632034842e-14 4.10275756606985e-12 0.819553861962665 0.875 11.5 11 5 small kidney 9.47388257941555e-13 3.89525337459441e-11 0.819553861962665 0.875 11.5 11 5 abnormal posture 1.0396095259522e-11 3.74786767508131e-10 0.819553861962665 0.875 11.5 11 5 overriding aortic valve 1.58618591784695e-07 2.80828289725572e-06 0.819553861962665 0.875 11.5 11 5 small heart 1.58618591784695e-07 2.80828289725572e-06 0.819553861962665 0.875 11.5 11 5 abnormal vasodilation 0.000247917118533413 0.00195465557005346 0.819553861962665 0.875 11.5 11 5 blindness 0.000247917118533413 0.00195465557005346 0.819553861962665 0.875 11.5 11 5 increased hemangiosarcoma incidence 0.000247917118533413 0.00195465557005346 0.819553861962665 0.875 11.5 11 5 abnormal osteoblast morphology 0.000247917118533413 0.00195465557005346 0.819553861962665 0.875 11.5 11 5 abnormal tympanic ring morphology 0.00309149051258827 0.0165023232833977 0.819553861962665 0.875 11.5 11 5 failure of tooth eruption 0.00309149051258827 0.0165023232833977 0.819553861962665 0.875 11.5 11 5 abnormal bone marrow cell number 0.00309149051258827 0.0165023232833977 0.819553861962665 0.875 11.5 11 5 poor circulation 0.00309149051258827 0.0165023232833977 0.819553861962665 0.875 11.5 11 5 abnormal pulmonary elastic fiber morphology 0.00309149051258827 0.0165023232833977 0.819553861962665 0.875 11.5 11 5 increased cochlear outer hair cell number 0.00309149051258827 0.0165023232833977 0.819553861962665 0.875 11.5 11 5 increased thymus weight 0.00309149051258827 0.0165023232833977 0.819553861962665 0.875 11.5 11 5 dystonia 0.00309149051258827 0.0165023232833977 0.819553861962665 0.875 11.5 11 5 decreased liver cholesterol level 0.00309149051258827 0.0165023232833977 0.819553861962665 0.875 11.5 11 5 abnormal thoracic cage shape 0.00309149051258827 0.0165023232833977 0.819553861962665 0.875 11.5 11 5 failure of vascular branching 0.0429045280755293 0.131596810835856 0.819553861962665 0.875 11.5 11 5 clubfoot 0.0429045280755293 0.131596810835856 0.819553861962665 0.875 11.5 11 5 abnormal pupil morphology 0.0429045280755293 0.131596810835856 0.819553861962665 0.875 11.5 11 5 absent eyelids 0.0429045280755293 0.131596810835856 0.819553861962665 0.875 11.5 11 5 spinning 0.0429045280755293 0.131596810835856 0.819553861962665 0.875 11.5 11 5 poor grooming 0.0429045280755293 0.131596810835856 0.819553861962665 0.875 11.5 11 5 abnormal urination 0.0429045280755293 0.131596810835856 0.819553861962665 0.875 11.5 11 5 abnormal hepatobiliary system morphology 0.0429045280755293 0.131596810835856 0.819553861962665 0.875 11.5 11 5 calcified muscle 0.0429045280755293 0.131596810835856 0.819553861962665 0.875 11.5 11 5 colon polyps 0.0429045280755293 0.131596810835856 0.819553861962665 0.875 11.5 11 5 abnormal perineum morphology 0.0429045280755293 0.131596810835856 0.819553861962665 0.875 11.5 11 5 liver failure 0.0429045280755293 0.131596810835856 0.819553861962665 0.875 11.5 11 5 liver cysts 0.0429045280755293 0.131596810835856 0.819553861962665 0.875 11.5 11 5 increased cardiac output 0.0429045280755293 0.131596810835856 0.819553861962665 0.875 11.5 11 5 elevated level of mitotic sister chromatid exchange 0.0429045280755293 0.131596810835856 0.819553861962665 0.875 11.5 11 5 bowed fibula 0.0429045280755293 0.131596810835856 0.819553861962665 0.875 11.5 11 5 abnormal choroid pigmentation 0.0429045280755293 0.131596810835856 0.819553861962665 0.875 11.5 11 5 abnormal olfactory tract morphology 0.0429045280755293 0.131596810835856 0.819553861962665 0.875 11.5 11 5 Sertoli cell hypoplasia 0.0429045280755293 0.131596810835856 0.819553861962665 0.875 11.5 11 5 hypergranulosis 0.0429045280755293 0.131596810835856 0.819553861962665 0.875 11.5 11 5 abnormal meiotic spindle morphology 0.0429045280755293 0.131596810835856 0.819553861962665 0.875 11.5 11 5 abnormal mitotic spindle assembly checkpoint 0.0429045280755293 0.131596810835856 0.819553861962665 0.875 11.5 11 5 abnormal sphingomyelin level 0.0429045280755293 0.131596810835856 0.819553861962665 0.875 11.5 11 5 abnormal olfactory bulb mitral cell layer morphology 0.0429045280755293 0.131596810835856 0.819553861962665 0.875 11.5 11 5 decreased hippocampus pyramidal cell number 0.0429045280755293 0.131596810835856 0.819553861962665 0.875 11.5 11 5 abnormal brain ependyma morphology 0.0429045280755293 0.131596810835856 0.819553861962665 0.875 11.5 11 5 pleural effusion 0.0429045280755293 0.131596810835856 0.819553861962665 0.875 11.5 11 5 heart right ventricle hypoplasia 0.0429045280755293 0.131596810835856 0.819553861962665 0.875 11.5 11 5 abnormal hepatic vein morphology 0.0429045280755293 0.131596810835856 0.819553861962665 0.875 11.5 11 5 anomalous pulmonary venous connection 0.0429045280755293 0.131596810835856 0.819553861962665 0.875 11.5 11 5 pulmonary artery hypoplasia 0.0429045280755293 0.131596810835856 0.819553861962665 0.875 11.5 11 5 abnormal visual evoked potential 0.0429045280755293 0.131596810835856 0.819553861962665 0.875 11.5 11 5 abnormal anterior commissure pars posterior morphology 0.0429045280755293 0.131596810835856 0.819553861962665 0.875 11.5 11 5 decreased alveolar lamellar body number 0.0429045280755293 0.131596810835856 0.819553861962665 0.875 11.5 11 5 abnormal pulmonary acinus morphology 0.0429045280755293 0.131596810835856 0.819553861962665 0.875 11.5 11 5 abnormal foramen magnum morphology 0.0429045280755293 0.131596810835856 0.819553861962665 0.875 11.5 11 5 abnormal macrophage activation involved in immune response 0.0429045280755293 0.131596810835856 0.819553861962665 0.875 11.5 11 5 lethality during fetal growth through weaning, incomplete penetrance 0.0429045280755293 0.131596810835856 0.819553861962665 0.875 11.5 11 5 increased circulating ferritin level 0.0429045280755293 0.131596810835856 0.819553861962665 0.875 11.5 11 5 abnormal heart echocardiography feature 0.0429045280755293 0.131596810835856 0.819553861962665 0.875 11.5 11 5 prolonged PQ interval 0.0429045280755293 0.131596810835856 0.819553861962665 0.875 11.5 11 5 increased circulating lactate level 0.0429045280755293 0.131596810835856 0.819553861962665 0.875 11.5 11 5 increased testis apoptosis 0.0429045280755293 0.131596810835856 0.819553861962665 0.875 11.5 11 5 absent hypoglossal canal 0.0429045280755293 0.131596810835856 0.819553861962665 0.875 11.5 11 5 decreased white adipose tissue mass 0.0429045280755293 0.131596810835856 0.819553861962665 0.875 11.5 11 5 decreased basal metabolism 0.0429045280755293 0.131596810835856 0.819553861962665 0.875 11.5 11 5 embryonic lethality between implantation and somite formation, complete penetrance 9.02758973488246e-33 2.64189758417884e-30 0.818120240046695 0.873469387755102 11.5 11 5 abnormal placenta morphology 1.76879107623455e-11 6.19699690441331e-10 0.818071847745734 0.873417721518987 11.5 11 5 impaired balance 2.29307734444908e-14 1.15232927157921e-12 0.817258192881537 0.872549019607843 11.5 11 5 pulmonary hypoplasia 2.70090744572247e-07 4.68188660016352e-06 0.817062816789526 0.872340425531915 11.5 11 5 increased oxygen consumption 2.73781543807465e-12 1.0558629305753e-10 0.816831091657141 0.872093023255814 11.5 11 5 increased circulating creatinine level 2.73781543807465e-12 1.0558629305753e-10 0.816831091657141 0.872093023255814 11.5 11 5 abnormal iris morphology 3.07223127162458e-06 3.98029962925319e-05 0.816551833164267 0.871794871794872 11.5 11 5 embryonic lethality between somite formation and embryo turning, complete penetrance 3.30895119574053e-10 9.57094895279601e-09 0.816208744158736 0.871428571428571 11.5 11 5 osteopetrosis 3.55666111275362e-05 0.000356427164091644 0.815777116055003 0.870967741935484 11.5 11 5 abnormal capillary morphology 3.55666111275362e-05 0.000356427164091644 0.815777116055003 0.870967741935484 11.5 11 5 inner cell mass degeneration 3.55666111275362e-05 0.000356427164091644 0.815777116055003 0.870967741935484 11.5 11 5 abnormal podocyte morphology 3.55666111275362e-05 0.000356427164091644 0.815777116055003 0.870967741935484 11.5 11 5 abnormal mitochondrial ATP synthesis coupled electron transport 3.55666111275362e-05 0.000356427164091644 0.815777116055003 0.870967741935484 11.5 11 5 impaired limb coordination 4.08060530820885e-08 8.28612710544451e-07 0.815217598142757 0.87037037037037 11.5 11 5 abnormal apoptosis 4.08060530820885e-08 8.28612710544451e-07 0.815217598142757 0.87037037037037 11.5 11 5 increased circulating alkaline phosphatase level 9.86257363121433e-22 1.16824532893551e-19 0.815217598142757 0.87037037037037 11.5 11 5 embryonic lethality during organogenesis, incomplete penetrance 3.98633193524963e-30 9.91600068893345e-28 0.814463465304512 0.869565217391304 11.5 11 5 abnormal forelimb morphology 4.58581669324833e-07 7.48014362259359e-06 0.814463465304512 0.869565217391304 11.5 11 5 failure to gastrulate 4.58581669324833e-07 7.48014362259359e-06 0.814463465304512 0.869565217391304 11.5 11 5 abnormal allantois morphology 4.58581669324833e-07 7.48014362259359e-06 0.814463465304512 0.869565217391304 11.5 11 5 embryonic lethality between implantation and placentation, complete penetrance 4.58581669324833e-07 7.48014362259359e-06 0.814463465304512 0.869565217391304 11.5 11 5 abnormal cranial nerve morphology 0.00042331466976748 0.00308796258371439 0.814463465304512 0.869565217391304 11.5 11 5 abnormal crista ampullaris morphology 0.00042331466976748 0.00308796258371439 0.814463465304512 0.869565217391304 11.5 11 5 abnormal chondrocyte physiology 0.00042331466976748 0.00308796258371439 0.814463465304512 0.869565217391304 11.5 11 5 abnormal palatal shelf fusion at midline 0.00042331466976748 0.00308796258371439 0.814463465304512 0.869565217391304 11.5 11 5 abnormal hepatocyte physiology 0.00042331466976748 0.00308796258371439 0.814463465304512 0.869565217391304 11.5 11 5 abnormal hematopoietic stem cell physiology 0.00042331466976748 0.00308796258371439 0.814463465304512 0.869565217391304 11.5 11 5 embryonic growth arrest 6.75068720057221e-30 1.59926994394508e-27 0.813929973951692 0.868995633187773 11.5 11 5 pallor 4.08655746376813e-23 5.64739538395734e-21 0.813532649915592 0.868571428571429 11.5 11 5 incomplete somite formation 5.21620105670458e-06 6.34489003841205e-05 0.813391802850164 0.868421052631579 11.5 11 5 decreased birth body size 1.59446827295104e-15 8.81386628659045e-14 0.813391802850164 0.868421052631579 11.5 11 5 enlarged kidney 6.9108850085777e-08 1.31968508809672e-06 0.812926741785069 0.867924528301887 11.5 11 5 increased circulating bilirubin level 6.9108850085777e-08 1.31968508809672e-06 0.812926741785069 0.867924528301887 11.5 11 5 embryonic lethality during organogenesis, complete penetrance 7.44303587774908e-71 7.40582069836034e-68 0.812863626354806 0.867857142857143 11.5 11 5 intracranial hemorrhage 1.04893436254747e-08 2.32966448824716e-07 0.81174858708683 0.866666666666667 11.5 11 5 abnormal incisor morphology 1.04893436254747e-08 2.32966448824716e-07 0.81174858708683 0.866666666666667 11.5 11 5 vagina atresia 0.00529270931607163 0.0252214835703605 0.81174858708683 0.866666666666667 11.5 11 5 no suckling reflex 0.00529270931607163 0.0252214835703605 0.81174858708683 0.866666666666667 11.5 11 5 abnormal apical ectodermal ridge morphology 0.00529270931607163 0.0252214835703605 0.81174858708683 0.866666666666667 11.5 11 5 placental labyrinth hypoplasia 0.00529270931607163 0.0252214835703605 0.81174858708683 0.866666666666667 11.5 11 5 abnormal pericyte morphology 0.00529270931607163 0.0252214835703605 0.81174858708683 0.866666666666667 11.5 11 5 abnormal placenta size 0.00529270931607163 0.0252214835703605 0.81174858708683 0.866666666666667 11.5 11 5 abnormal zygomatic bone morphology 0.00529270931607163 0.0252214835703605 0.81174858708683 0.866666666666667 11.5 11 5 decreased thymocyte apoptosis 0.00529270931607163 0.0252214835703605 0.81174858708683 0.866666666666667 11.5 11 5 abnormal secondary palate development 0.00529270931607163 0.0252214835703605 0.81174858708683 0.866666666666667 11.5 11 5 abnormal aorta wall morphology 0.00529270931607163 0.0252214835703605 0.81174858708683 0.866666666666667 11.5 11 5 abnormal coronary vessel morphology 0.00529270931607163 0.0252214835703605 0.81174858708683 0.866666666666667 11.5 11 5 abnormal branching involved in lung morphogenesis 0.00529270931607163 0.0252214835703605 0.81174858708683 0.866666666666667 11.5 11 5 edema 1.96764611189801e-22 2.64568632613313e-20 0.811385551046093 0.866279069767442 11.5 11 5 decreased erythrocyte cell number 1.36004952481551e-20 1.30120122806869e-18 0.811350866074048 0.866242038216561 11.5 11 5 distended pericardium 1.16729653307698e-07 2.11945264673648e-06 0.810547775567471 0.865384615384615 11.5 11 5 eyelids open at birth 1.16729653307698e-07 2.11945264673648e-06 0.810547775567471 0.865384615384615 11.5 11 5 kinked neural tube 1.16729653307698e-07 2.11945264673648e-06 0.810547775567471 0.865384615384615 11.5 11 5 decreased width of hypertrophic chondrocyte zone 8.82450965885725e-06 0.000102574615777605 0.810060960086649 0.864864864864865 11.5 11 5 abnormal respiratory electron transport chain 8.82450965885725e-06 0.000102574615777605 0.810060960086649 0.864864864864865 11.5 11 5 increased neuron apoptosis 3.77359963873205e-11 1.28586700018438e-09 0.809435913049545 0.864197530864197 11.5 11 5 abnormal astrocyte morphology 1.30996737615872e-06 1.84620048056363e-05 0.808910305313799 0.863636363636364 11.5 11 5 omphalocele 1.30996737615872e-06 1.84620048056363e-05 0.808910305313799 0.863636363636364 11.5 11 5 abnormal long bone epiphysis morphology 0.000718809428641094 0.0047936687767955 0.808910305313799 0.863636363636364 11.5 11 5 abnormal enterocyte morphology 0.000718809428641094 0.0047936687767955 0.808910305313799 0.863636363636364 11.5 11 5 increased myocardial infarction size 0.000718809428641094 0.0047936687767955 0.808910305313799 0.863636363636364 11.5 11 5 abnormal basement membrane morphology 0.000718809428641094 0.0047936687767955 0.808910305313799 0.863636363636364 11.5 11 5 abnormal blood-brain barrier function 0.000718809428641094 0.0047936687767955 0.808910305313799 0.863636363636364 11.5 11 5 abnormal mesenteric lymph node morphology 0.000718809428641094 0.0047936687767955 0.808910305313799 0.863636363636364 11.5 11 5 abnormal cerebral cortex pyramidal cell morphology 0.000718809428641094 0.0047936687767955 0.808910305313799 0.863636363636364 11.5 11 5 increased mammary gland tumor incidence 0.000718809428641094 0.0047936687767955 0.808910305313799 0.863636363636364 11.5 11 5 embryonic lethality before implantation, incomplete penetrance 0.000718809428641094 0.0047936687767955 0.808910305313799 0.863636363636364 11.5 11 5 abnormal vascular development 2.69581249115938e-09 6.51051803083394e-08 0.808910305313799 0.863636363636364 11.5 11 5 prenatal lethality, complete penetrance 9.21036042614513e-35 3.52473408615938e-32 0.808604015913832 0.863309352517986 11.5 11 5 abnormal eye morphology 4.48647571518036e-18 3.43387948969574e-16 0.808604015913832 0.863309352517986 11.5 11 5 astrocytosis 4.12757704579638e-10 1.17341118873354e-08 0.808327096730299 0.863013698630137 11.5 11 5 abnormal trophoblast layer morphology 1.96617230518007e-07 3.43217797132311e-06 0.808075516557025 0.862745098039216 11.5 11 5 failure of chorioallantoic fusion 1.96617230518007e-07 3.43217797132311e-06 0.808075516557025 0.862745098039216 11.5 11 5 short sternum 0.000102073134572411 0.000911694514358608 0.807442228534645 0.862068965517241 11.5 11 5 abnormal digit morphology 6.92926078445919e-10 1.85339098939164e-08 0.80654507050294 0.861111111111111 11.5 11 5 hydroencephaly 5.62591784947121e-15 3.04227622838253e-13 0.806318830651467 0.860869565217391 11.5 11 5 abnormal placenta labyrinth morphology 1.06406791254698e-10 3.30858616557576e-09 0.806215734010289 0.860759493670886 11.5 11 5 ventricular septal defect 2.11709708003762e-17 1.5264576772735e-15 0.805779847475897 0.860294117647059 11.5 11 5 abnormal interventricular septum morphology 3.30222344362414e-07 5.5501897405507e-06 0.805504367186162 0.86 11.5 11 5 increased circulating chloride level 3.30222344362414e-07 5.5501897405507e-06 0.805504367186162 0.86 11.5 11 5 increased hepatocellular carcinoma incidence 4.99131048029176e-08 1.00128103384885e-06 0.805175724033495 0.859649122807018 11.5 11 5 abnormal facial morphology 4.99131048029176e-08 1.00128103384885e-06 0.805175724033495 0.859649122807018 11.5 11 5 decreased circulating serum albumin level 6.54984005936586e-13 2.76147917757163e-11 0.804179835692081 0.858585858585859 11.5 11 5 rib bifurcation 0.000171701662884383 0.0014119268972724 0.802828272943019 0.857142857142857 11.5 11 5 lymphoid hyperplasia 0.000171701662884383 0.0014119268972724 0.802828272943019 0.857142857142857 11.5 11 5 straub tail 0.000171701662884383 0.0014119268972724 0.802828272943019 0.857142857142857 11.5 11 5 small ears 0.00121322574071953 0.00754474757509958 0.802828272943019 0.857142857142857 11.5 11 5 abnormal eye pigmentation 0.00121322574071953 0.00754474757509958 0.802828272943019 0.857142857142857 11.5 11 5 liver degeneration 0.00121322574071953 0.00754474757509958 0.802828272943019 0.857142857142857 11.5 11 5 abnormal stapes morphology 0.00121322574071953 0.00754474757509958 0.802828272943019 0.857142857142857 11.5 11 5 vascular ring 0.00121322574071953 0.00754474757509958 0.802828272943019 0.857142857142857 11.5 11 5 absent segment of posterior cerebral artery 0.00121322574071953 0.00754474757509958 0.802828272943019 0.857142857142857 11.5 11 5 abnormal blood flow velocity 0.00898816649704893 0.0392936101254995 0.802828272943019 0.857142857142857 11.5 11 5 absent atrioventricular cushions 0.00898816649704893 0.0392936101254995 0.802828272943019 0.857142857142857 11.5 11 5 extended life span 0.00898816649704893 0.0392936101254995 0.802828272943019 0.857142857142857 11.5 11 5 abnormal fluid regulation 0.00898816649704893 0.0392936101254995 0.802828272943019 0.857142857142857 11.5 11 5 increased lactate dehydrogenase level 0.00898816649704893 0.0392936101254995 0.802828272943019 0.857142857142857 11.5 11 5 abnormal kidney medulla morphology 0.00898816649704893 0.0392936101254995 0.802828272943019 0.857142857142857 11.5 11 5 intestinal obstruction 0.00898816649704893 0.0392936101254995 0.802828272943019 0.857142857142857 11.5 11 5 amyloid beta deposits 0.00898816649704893 0.0392936101254995 0.802828272943019 0.857142857142857 11.5 11 5 failure of zygotic cell division 0.00898816649704893 0.0392936101254995 0.802828272943019 0.857142857142857 11.5 11 5 abnormal vascular endothelial cell migration 0.00898816649704893 0.0392936101254995 0.802828272943019 0.857142857142857 11.5 11 5 abnormal sagittal suture morphology 0.00898816649704893 0.0392936101254995 0.802828272943019 0.857142857142857 11.5 11 5 abnormal decidualization 0.00898816649704893 0.0392936101254995 0.802828272943019 0.857142857142857 11.5 11 5 decreased CNS synapse formation 0.00898816649704893 0.0392936101254995 0.802828272943019 0.857142857142857 11.5 11 5 increased pulmonary respiratory rate 0.00898816649704893 0.0392936101254995 0.802828272943019 0.857142857142857 11.5 11 5 sternebra fusion 0.00898816649704893 0.0392936101254995 0.802828272943019 0.857142857142857 11.5 11 5 increased stomach tumor incidence 0.00898816649704893 0.0392936101254995 0.802828272943019 0.857142857142857 11.5 11 5 testis degeneration 0.00898816649704893 0.0392936101254995 0.802828272943019 0.857142857142857 11.5 11 5 asymmetric rib joints 0.0739371464527817 0.194007016668032 0.802828272943019 0.857142857142857 11.5 11 5 failure of atrioventricular cushion closure 0.0739371464527817 0.194007016668032 0.802828272943019 0.857142857142857 11.5 11 5 cellular necrosis 0.0739371464527817 0.194007016668032 0.802828272943019 0.857142857142857 11.5 11 5 abnormal oculomotor nerve morphology 0.0739371464527817 0.194007016668032 0.802828272943019 0.857142857142857 11.5 11 5 absent epidermis stratum corneum 0.0739371464527817 0.194007016668032 0.802828272943019 0.857142857142857 11.5 11 5 abnormal lacrimal gland morphology 0.0739371464527817 0.194007016668032 0.802828272943019 0.857142857142857 11.5 11 5 excessive tearing 0.0739371464527817 0.194007016668032 0.802828272943019 0.857142857142857 11.5 11 5 abnormal circulating free fatty acids level 0.0739371464527817 0.194007016668032 0.802828272943019 0.857142857142857 11.5 11 5 abnormal axial mesoderm 0.0739371464527817 0.194007016668032 0.802828272943019 0.857142857142857 11.5 11 5 abnormal gastrulation movements 0.0739371464527817 0.194007016668032 0.802828272943019 0.857142857142857 11.5 11 5 abnormal superior semicircular canal morphology 0.0739371464527817 0.194007016668032 0.802828272943019 0.857142857142857 11.5 11 5 detached tectorial membrane 0.0739371464527817 0.194007016668032 0.802828272943019 0.857142857142857 11.5 11 5 decreased lateral semicircular canal size 0.0739371464527817 0.194007016668032 0.802828272943019 0.857142857142857 11.5 11 5 decreased cholesterol efflux 0.0739371464527817 0.194007016668032 0.802828272943019 0.857142857142857 11.5 11 5 calcinosis 0.0739371464527817 0.194007016668032 0.802828272943019 0.857142857142857 11.5 11 5 aorta coarctation 0.0739371464527817 0.194007016668032 0.802828272943019 0.857142857142857 11.5 11 5 anuria 0.0739371464527817 0.194007016668032 0.802828272943019 0.857142857142857 11.5 11 5 increased ectoderm apoptosis 0.0739371464527817 0.194007016668032 0.802828272943019 0.857142857142857 11.5 11 5 abnormal vestibular saccular macula morphology 0.0739371464527817 0.194007016668032 0.802828272943019 0.857142857142857 11.5 11 5 utricular macular degeneration 0.0739371464527817 0.194007016668032 0.802828272943019 0.857142857142857 11.5 11 5 absent deltoid tuberosity 0.0739371464527817 0.194007016668032 0.802828272943019 0.857142857142857 11.5 11 5 abnormal cochlear nerve compound action potential 0.0739371464527817 0.194007016668032 0.802828272943019 0.857142857142857 11.5 11 5 abnormal gallbladder morphology 0.0739371464527817 0.194007016668032 0.802828272943019 0.857142857142857 11.5 11 5 abnormal ciliary body morphology 0.0739371464527817 0.194007016668032 0.802828272943019 0.857142857142857 11.5 11 5 abnormal thyroid hormone level 0.0739371464527817 0.194007016668032 0.802828272943019 0.857142857142857 11.5 11 5 increased chronic myelocytic leukemia incidence 0.0739371464527817 0.194007016668032 0.802828272943019 0.857142857142857 11.5 11 5 abnormal renal/urinary system physiology 0.0739371464527817 0.194007016668032 0.802828272943019 0.857142857142857 11.5 11 5 decreased tidal volume 0.0739371464527817 0.194007016668032 0.802828272943019 0.857142857142857 11.5 11 5 abnormal uterus physiology 0.0739371464527817 0.194007016668032 0.802828272943019 0.857142857142857 11.5 11 5 heart hemorrhage 0.0739371464527817 0.194007016668032 0.802828272943019 0.857142857142857 11.5 11 5 enhanced behavioral response to alcohol 0.0739371464527817 0.194007016668032 0.802828272943019 0.857142857142857 11.5 11 5 abnormal cerebellum white matter morphology 0.0739371464527817 0.194007016668032 0.802828272943019 0.857142857142857 11.5 11 5 decreased DN2 thymocyte number 0.0739371464527817 0.194007016668032 0.802828272943019 0.857142857142857 11.5 11 5 arteritis 0.0739371464527817 0.194007016668032 0.802828272943019 0.857142857142857 11.5 11 5 decreased skeletal muscle glycogen level 0.0739371464527817 0.194007016668032 0.802828272943019 0.857142857142857 11.5 11 5 heart right ventricle outflow tract stenosis 0.0739371464527817 0.194007016668032 0.802828272943019 0.857142857142857 11.5 11 5 heart block 0.0739371464527817 0.194007016668032 0.802828272943019 0.857142857142857 11.5 11 5 thick pulmonary valve 0.0739371464527817 0.194007016668032 0.802828272943019 0.857142857142857 11.5 11 5 altered tumor pathology 0.0739371464527817 0.194007016668032 0.802828272943019 0.857142857142857 11.5 11 5 increased right ventricle systolic pressure 0.0739371464527817 0.194007016668032 0.802828272943019 0.857142857142857 11.5 11 5 abnormal tricarboxylic acid cycle 0.0739371464527817 0.194007016668032 0.802828272943019 0.857142857142857 11.5 11 5 increased compact bone volume 0.0739371464527817 0.194007016668032 0.802828272943019 0.857142857142857 11.5 11 5 impaired branching involved in bronchus morphogenesis 0.0739371464527817 0.194007016668032 0.802828272943019 0.857142857142857 11.5 11 5 abnormal brain ependyma motile cilium physiology 0.0739371464527817 0.194007016668032 0.802828272943019 0.857142857142857 11.5 11 5 embryonic lethality at implantation, incomplete penetrance 0.0739371464527817 0.194007016668032 0.802828272943019 0.857142857142857 11.5 11 5 parturition failure 0.0739371464527817 0.194007016668032 0.802828272943019 0.857142857142857 11.5 11 5 impaired mammary gland growth during pregnancy 0.0739371464527817 0.194007016668032 0.802828272943019 0.857142857142857 11.5 11 5 decreased CD8-positive, naive alpha-beta T cell number 0.0739371464527817 0.194007016668032 0.802828272943019 0.857142857142857 11.5 11 5 fragmented Meckel's cartilage 0.0739371464527817 0.194007016668032 0.802828272943019 0.857142857142857 11.5 11 5 absent connection between subcutaneous lymph vessels and lymph sac 0.0739371464527817 0.194007016668032 0.802828272943019 0.857142857142857 11.5 11 5 holoprosencephaly 2.49644363465535e-05 0.000264251214519369 0.802828272943019 0.857142857142857 11.5 11 5 abnormal sternum morphology 3.23593356466013e-09 7.5937591906529e-08 0.800889074216103 0.855072463768116 11.5 11 5 cleft palate 2.74429172680286e-16 1.66498187083466e-14 0.800785452910085 0.854961832061069 11.5 11 5 increased circulating calcium level 1.39351303260631e-07 2.49378681194834e-06 0.800395459994706 0.854545454545454 11.5 11 5 perinatal lethality, complete penetrance 1.57768645429093e-25 2.37848185154465e-23 0.800315508395466 0.854460093896714 11.5 11 5 oligodactyly 9.22999068042203e-07 1.37482645614071e-05 0.800040674773078 0.854166666666667 11.5 11 5 curly tail 9.22999068042203e-07 1.37482645614071e-05 0.800040674773078 0.854166666666667 11.5 11 5 decreased rib number 1.9622183703637e-11 6.82659887591566e-10 0.799821425478813 0.853932584269663 11.5 11 5 decreased mean corpuscular hemoglobin 5.38421918855209e-09 1.24588327735101e-07 0.798892840232514 0.852941176470588 11.5 11 5 abnormal endoderm development 4.17276089805276e-05 0.000416021752861973 0.798892840232514 0.852941176470588 11.5 11 5 embryonic lethality, complete penetrance 4.00760080220059e-37 1.81252854463163e-34 0.798633767859722 0.852664576802508 11.5 11 5 abnormal heart valve morphology 0.000287339445421872 0.00223711070574932 0.797872542863123 0.851851851851852 11.5 11 5 thin epidermis 0.000287339445421872 0.00223711070574932 0.797872542863123 0.851851851851852 11.5 11 5 increased brain weight 0.000287339445421872 0.00223711070574932 0.797872542863123 0.851851851851852 11.5 11 5 abnormal type II pneumocyte morphology 0.000287339445421872 0.00223711070574932 0.797872542863123 0.851851851851852 11.5 11 5 abnormal palate morphology 0.000287339445421872 0.00223711070574932 0.797872542863123 0.851851851851852 11.5 11 5 abnormal kidney morphology 7.79405039152821e-21 7.75508013957057e-19 0.797476084456732 0.851428571428571 11.5 11 5 abnormal angiogenesis 1.37149061298307e-09 3.53531906714548e-08 0.797403757585295 0.851351351351351 11.5 11 5 pale liver 1.37149061298307e-09 3.53531906714548e-08 0.797403757585295 0.851351351351351 11.5 11 5 decreased hemoglobin content 5.06613083069424e-17 3.31631590561893e-15 0.797134455404416 0.851063829787234 11.5 11 5 abnormal cell nucleus morphology 1.53567266791101e-06 2.14605941653295e-05 0.797134455404416 0.851063829787234 11.5 11 5 neuron degeneration 1.53567266791101e-06 2.14605941653295e-05 0.797134455404416 0.851063829787234 11.5 11 5 abnormal blood homeostasis 5.1863577496767e-14 2.55466631729125e-12 0.796959645216827 0.850877192982456 11.5 11 5 epidermal hyperplasia 5.84771437411484e-08 1.13642105512583e-06 0.79613803733516 0.85 11.5 11 5 increased erythrocyte cell number 5.84771437411484e-08 1.13642105512583e-06 0.79613803733516 0.85 11.5 11 5 decreased circulating phosphate level 1.02628344941479e-05 0.000118188892612004 0.79613803733516 0.85 11.5 11 5 abnormal basioccipital bone morphology 0.00203423127027358 0.0115265382341812 0.79613803733516 0.85 11.5 11 5 abnormal circulating enzyme level 0.00203423127027358 0.0115265382341812 0.79613803733516 0.85 11.5 11 5 increased urine glucose level 0.00203423127027358 0.0115265382341812 0.79613803733516 0.85 11.5 11 5 abnormal hearing physiology 0.00203423127027358 0.0115265382341812 0.79613803733516 0.85 11.5 11 5 abnormal heart right ventricle morphology 0.00203423127027358 0.0115265382341812 0.79613803733516 0.85 11.5 11 5 abnormal optic stalk morphology 0.00203423127027358 0.0115265382341812 0.79613803733516 0.85 11.5 11 5 increased urine calcium level 0.00203423127027358 0.0115265382341812 0.79613803733516 0.85 11.5 11 5 abnormal sperm mitochondrial sheath morphology 0.00203423127027358 0.0115265382341812 0.79613803733516 0.85 11.5 11 5 abnormal neuron proliferation 0.00203423127027358 0.0115265382341812 0.79613803733516 0.85 11.5 11 5 decreased muscle cell glucose uptake 0.00203423127027358 0.0115265382341812 0.79613803733516 0.85 11.5 11 5 decreased percent body fat/body weight 2.2720569129649e-09 5.59578373366355e-08 0.795496507893311 0.849315068493151 11.5 11 5 single kidney 6.9434123153127e-05 0.000644467840833594 0.794718896448645 0.848484848484849 11.5 11 5 abnormal QRS complex 6.9434123153127e-05 0.000644467840833594 0.794718896448645 0.848484848484849 11.5 11 5 increased osteoblast cell number 6.9434123153127e-05 0.000644467840833594 0.794718896448645 0.848484848484849 11.5 11 5 abnormal coat/hair pigmentation 1.418610080489e-13 6.53480106521554e-12 0.794465478433195 0.848214285714286 11.5 11 5 abnormal somite development 5.78781022341498e-10 1.57346206893385e-08 0.794359620274843 0.848101265822785 11.5 11 5 abnormal nervous system morphology 5.78781022341498e-10 1.57346206893385e-08 0.794359620274843 0.848101265822785 11.5 11 5 cardiac fibrosis 1.47692146529222e-10 4.50778177290109e-09 0.793383234437807 0.847058823529412 11.5 11 5 abnormal skin condition 6.35998905174719e-07 9.79595836917718e-06 0.792535602777082 0.846153846153846 11.5 11 5 abnormal heart looping 1.70080348746446e-05 0.000186788020974298 0.792535602777082 0.846153846153846 11.5 11 5 abnormal nasal bone morphology 0.000478197785979459 0.00342800286058762 0.792535602777082 0.846153846153846 11.5 11 5 abnormal xiphoid process morphology 0.000478197785979459 0.00342800286058762 0.792535602777082 0.846153846153846 11.5 11 5 heart inflammation 0.000478197785979459 0.00342800286058762 0.792535602777082 0.846153846153846 11.5 11 5 decreased circulating glycerol level 0.000478197785979459 0.00342800286058762 0.792535602777082 0.846153846153846 11.5 11 5 decreased bone resorption 0.000478197785979459 0.00342800286058762 0.792535602777082 0.846153846153846 11.5 11 5 abnormal nerve conduction 0.000478197785979459 0.00342800286058762 0.792535602777082 0.846153846153846 11.5 11 5 short premaxilla 0.0151238401276544 0.0588741037833181 0.792535602777082 0.846153846153846 11.5 11 5 absent teeth 0.0151238401276544 0.0588741037833181 0.792535602777082 0.846153846153846 11.5 11 5 absent trabeculae carneae 0.0151238401276544 0.0588741037833181 0.792535602777082 0.846153846153846 11.5 11 5 abnormal renal/urinary system morphology 0.0151238401276544 0.0588741037833181 0.792535602777082 0.846153846153846 11.5 11 5 increased foot pad pigmentation 0.0151238401276544 0.0588741037833181 0.792535602777082 0.846153846153846 11.5 11 5 tight skin 0.0151238401276544 0.0588741037833181 0.792535602777082 0.846153846153846 11.5 11 5 pup cannibalization 0.0151238401276544 0.0588741037833181 0.792535602777082 0.846153846153846 11.5 11 5 abnormal grip strength 0.0151238401276544 0.0588741037833181 0.792535602777082 0.846153846153846 11.5 11 5 abnormal pulmonary alveolus epithelial cell morphology 0.0151238401276544 0.0588741037833181 0.792535602777082 0.846153846153846 11.5 11 5 abnormal lung interstitium morphology 0.0151238401276544 0.0588741037833181 0.792535602777082 0.846153846153846 11.5 11 5 abnormal bile duct development 0.0151238401276544 0.0588741037833181 0.792535602777082 0.846153846153846 11.5 11 5 abnormal soleus morphology 0.0151238401276544 0.0588741037833181 0.792535602777082 0.846153846153846 11.5 11 5 absent lateral semicircular canal 0.0151238401276544 0.0588741037833181 0.792535602777082 0.846153846153846 11.5 11 5 axonal dystrophy 0.0151238401276544 0.0588741037833181 0.792535602777082 0.846153846153846 11.5 11 5 tracheoesophageal fistula 0.0151238401276544 0.0588741037833181 0.792535602777082 0.846153846153846 11.5 11 5 increased cochlear inner hair cell number 0.0151238401276544 0.0588741037833181 0.792535602777082 0.846153846153846 11.5 11 5 small pituitary gland 0.0151238401276544 0.0588741037833181 0.792535602777082 0.846153846153846 11.5 11 5 orthokeratosis 0.0151238401276544 0.0588741037833181 0.792535602777082 0.846153846153846 11.5 11 5 empty decidua capsularis 0.0151238401276544 0.0588741037833181 0.792535602777082 0.846153846153846 11.5 11 5 abnormal aorta tunica media morphology 0.0151238401276544 0.0588741037833181 0.792535602777082 0.846153846153846 11.5 11 5 decreased cardiac stroke volume 0.0151238401276544 0.0588741037833181 0.792535602777082 0.846153846153846 11.5 11 5 abnormal embryonic neuroepithelium morphology 1.59684536001845e-07 2.81712966882687e-06 0.791293383963952 0.844827586206897 11.5 11 5 abnormal ectoderm development 4.20711272253189e-06 5.2988318467332e-05 0.79093452075127 0.844444444444444 11.5 11 5 decreased circulating HDL cholesterol level 6.54030025866075e-15 3.49870900933733e-13 0.790284081178284 0.84375 11.5 11 5 decreased circulating LDL cholesterol level 4.02606873131616e-08 8.24267157954647e-07 0.790284081178284 0.84375 11.5 11 5 polydipsia 0.000114987497741307 0.000998364400109953 0.790284081178284 0.84375 11.5 11 5 failure of primitive streak formation 0.000114987497741307 0.000998364400109953 0.790284081178284 0.84375 11.5 11 5 bradykinesia 0.000114987497741307 0.000998364400109953 0.790284081178284 0.84375 11.5 11 5 increased fatty acid level 0.000114987497741307 0.000998364400109953 0.790284081178284 0.84375 11.5 11 5 short tail 4.00352054453349e-10 1.14468475339392e-08 0.789931433217026 0.843373493975904 11.5 11 5 microphthalmia 1.74759775333603e-17 1.2976565407234e-15 0.789710163908002 0.843137254901961 11.5 11 5 distended abdomen 1.04834983127609e-06 1.52948399137788e-05 0.789710163908002 0.843137254901961 11.5 11 5 abnormal gastrulation 1.04834983127609e-06 1.52948399137788e-05 0.789710163908002 0.843137254901961 11.5 11 5 short snout 1.04146294904807e-12 4.21242127765377e-11 0.789200015223307 0.842592592592593 11.5 11 5 decreased hematocrit 1.113720308923e-16 7.01361840112904e-15 0.789081213474816 0.842465753424658 11.5 11 5 decreased total retina thickness 2.80688222036715e-05 0.000291528998879469 0.788743566400159 0.842105263157895 11.5 11 5 abnormal stationary movement 0.00338615777463906 0.017676951656694 0.788743566400159 0.842105263157895 11.5 11 5 stereotypic behavior 0.00338615777463906 0.017676951656694 0.788743566400159 0.842105263157895 11.5 11 5 delayed sexual maturation 0.00338615777463906 0.017676951656694 0.788743566400159 0.842105263157895 11.5 11 5 increased malignant tumor incidence 0.00338615777463906 0.017676951656694 0.788743566400159 0.842105263157895 11.5 11 5 abnormal ear morphology 0.00338615777463906 0.017676951656694 0.788743566400159 0.842105263157895 11.5 11 5 abnormal digestive system development 0.00338615777463906 0.017676951656694 0.788743566400159 0.842105263157895 11.5 11 5 oliguria 0.00338615777463906 0.017676951656694 0.788743566400159 0.842105263157895 11.5 11 5 absent amnion 0.00338615777463906 0.017676951656694 0.788743566400159 0.842105263157895 11.5 11 5 decreased liver regeneration 0.00338615777463906 0.017676951656694 0.788743566400159 0.842105263157895 11.5 11 5 Leydig cell hypoplasia 0.00338615777463906 0.017676951656694 0.788743566400159 0.842105263157895 11.5 11 5 increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 0.00338615777463906 0.017676951656694 0.788743566400159 0.842105263157895 11.5 11 5 ataxia 2.07065637889341e-22 2.66401952649858e-20 0.78825548251006 0.841584158415842 11.5 11 5 gliosis 6.61401321264229e-08 1.27537657879439e-06 0.787961082703333 0.841269841269841 11.5 11 5 infertility 1.70725972754192e-12 6.8496912455815e-11 0.787822137000159 0.841121495327103 11.5 11 5 renal interstitial fibrosis 6.92525824201242e-06 8.22271115847537e-05 0.787623192016068 0.840909090909091 11.5 11 5 decreased blood urea nitrogen level 6.92525824201242e-06 8.22271115847537e-05 0.787623192016068 0.840909090909091 11.5 11 5 cleft secondary palate 4.27239462237953e-11 1.43615967880663e-09 0.78717027471186 0.840425531914894 11.5 11 5 enlarged liver 1.09189153281228e-11 3.90802904729576e-10 0.786771707484158 0.84 11.5 11 5 ruffled hair 0.00079109073870022 0.00516492969164513 0.786771707484158 0.84 11.5 11 5 mandible hypoplasia 0.00079109073870022 0.00516492969164513 0.786771707484158 0.84 11.5 11 5 abnormal primitive streak morphology 0.00079109073870022 0.00516492969164513 0.786771707484158 0.84 11.5 11 5 abnormal preimplantation embryo development 0.00079109073870022 0.00516492969164513 0.786771707484158 0.84 11.5 11 5 increased liver glycogen level 0.00079109073870022 0.00516492969164513 0.786771707484158 0.84 11.5 11 5 increased insulin sensitivity 4.88602621439593e-16 2.85976240195527e-14 0.785985721762396 0.839160839160839 11.5 11 5 short limbs 2.7394345654005e-10 8.01687468403969e-09 0.785910435773721 0.839080459770115 11.5 11 5 prenatal lethality 1.08350726270318e-07 1.99646245627715e-06 0.785563148793706 0.838709677419355 11.5 11 5 abnormal eyelid morphology 0.000189463593003961 0.00154521536917165 0.785563148793706 0.838709677419355 11.5 11 5 abnormal lipid homeostasis 1.2084618105535e-14 6.19803866752954e-13 0.785330733660927 0.838461538461538 11.5 11 5 abnormal intestine morphology 6.92498279620435e-09 1.58035731243654e-07 0.784746555083942 0.837837837837838 11.5 11 5 increased erythroid progenitor cell number 4.61190320885795e-05 0.000456147484375115 0.784746555083942 0.837837837837838 11.5 11 5 abnormal hair follicle development 4.61190320885795e-05 0.000456147484375115 0.784746555083942 0.837837837837838 11.5 11 5 abnormal blood circulation 1.13552088083416e-05 0.00012897754297146 0.784157847990855 0.837209302325581 11.5 11 5 abnormal long bone hypertrophic chondrocyte zone 2.81950925311256e-06 3.69133119321973e-05 0.783713314063423 0.836734693877551 11.5 11 5 absent kidney 2.81950925311256e-06 3.69133119321973e-05 0.783713314063423 0.836734693877551 11.5 11 5 decreased cardiac muscle contractility 7.44296033377101e-12 2.70282683653363e-10 0.783529516381888 0.836538461538462 11.5 11 5 decreased circulating cholesterol level 9.70042208585695e-20 8.04326664618972e-18 0.783086594100157 0.836065573770492 11.5 11 5 decreased white adipose tissue amount 4.46369357606038e-08 9.02718517922779e-07 0.782857420382247 0.835820895522388 11.5 11 5 decreased body length 8.559612090484e-29 1.70336280600632e-26 0.782806399955997 0.835766423357664 11.5 11 5 abnormal heart development 3.59995800932319e-17 2.45339604060039e-15 0.782503506539398 0.835443037974684 11.5 11 5 abnormal visceral yolk sac morphology 2.86600529316033e-09 6.85498862186184e-08 0.782503506539398 0.835443037974684 11.5 11 5 abnormal myocardium layer morphology 2.86600529316033e-09 6.85498862186184e-08 0.782503506539398 0.835443037974684 11.5 11 5 small spleen 1.85727945220313e-10 5.59997895437003e-09 0.782242932611146 0.835164835164835 11.5 11 5 abnormal behavior 5.83148569776727e-29 1.2613757107127e-26 0.781650548716704 0.834532374100719 11.5 11 5 thrombocytopenia 8.85188014840431e-16 5.00432997026267e-14 0.781604077221537 0.83448275862069 11.5 11 5 abnormal enzyme/coenzyme activity 5.85260564829527e-17 3.78139131172324e-15 0.781521790115444 0.834394904458599 11.5 11 5 kyphosis 3.69518200975347e-16 2.2148831925932e-14 0.78052748758349 0.833333333333333 11.5 11 5 abnormal axon morphology 5.03624362001123e-12 1.85594903774488e-10 0.78052748758349 0.833333333333333 11.5 11 5 absent mesoderm 2.88236697534806e-07 4.97908878554048e-06 0.78052748758349 0.833333333333333 11.5 11 5 abnormal osteoblast physiology 1.14833036430105e-06 1.65113975791841e-05 0.78052748758349 0.833333333333333 11.5 11 5 axon degeneration 1.14833036430105e-06 1.65113975791841e-05 0.78052748758349 0.833333333333333 11.5 11 5 abnormal kidney physiology 4.5990406672551e-06 5.74880083406887e-05 0.78052748758349 0.833333333333333 11.5 11 5 reduced long term depression 7.54252678149891e-05 0.000694890198851057 0.78052748758349 0.833333333333333 11.5 11 5 renal hypoplasia 7.54252678149891e-05 0.000694890198851057 0.78052748758349 0.833333333333333 11.5 11 5 narrow eye opening 7.54252678149891e-05 0.000694890198851057 0.78052748758349 0.833333333333333 11.5 11 5 emphysema 0.000310495282541604 0.00239490547386741 0.78052748758349 0.833333333333333 11.5 11 5 abnormal optic cup morphology 0.000310495282541604 0.00239490547386741 0.78052748758349 0.833333333333333 11.5 11 5 ocular hypertelorism 0.00130030242593781 0.00790831854405944 0.78052748758349 0.833333333333333 11.5 11 5 hemolytic anemia 0.00130030242593781 0.00790831854405944 0.78052748758349 0.833333333333333 11.5 11 5 abnormal sensory capabilities/reflexes/nociception 0.00130030242593781 0.00790831854405944 0.78052748758349 0.833333333333333 11.5 11 5 abnormal impulse conducting system conduction 0.00130030242593781 0.00790831854405944 0.78052748758349 0.833333333333333 11.5 11 5 prolonged QT interval 0.00130030242593781 0.00790831854405944 0.78052748758349 0.833333333333333 11.5 11 5 increased body temperature 0.00130030242593781 0.00790831854405944 0.78052748758349 0.833333333333333 11.5 11 5 abnormal inner cell mass apoptosis 0.00130030242593781 0.00790831854405944 0.78052748758349 0.833333333333333 11.5 11 5 abnormal truncus arteriosus septation 0.00130030242593781 0.00790831854405944 0.78052748758349 0.833333333333333 11.5 11 5 abnormal heart shape 0.00559159922821187 0.0261695260210292 0.78052748758349 0.833333333333333 11.5 11 5 right pulmonary isomerism 0.00559159922821187 0.0261695260210292 0.78052748758349 0.833333333333333 11.5 11 5 abnormal phrenic nerve morphology 0.00559159922821187 0.0261695260210292 0.78052748758349 0.833333333333333 11.5 11 5 abnormal thyroid cartilage morphology 0.00559159922821187 0.0261695260210292 0.78052748758349 0.833333333333333 11.5 11 5 acidosis 0.00559159922821187 0.0261695260210292 0.78052748758349 0.833333333333333 11.5 11 5 absent allantois 0.00559159922821187 0.0261695260210292 0.78052748758349 0.833333333333333 11.5 11 5 abnormal redox activity 0.00559159922821187 0.0261695260210292 0.78052748758349 0.833333333333333 11.5 11 5 long tibia 0.00559159922821187 0.0261695260210292 0.78052748758349 0.833333333333333 11.5 11 5 abnormal glycogen homeostasis 0.00559159922821187 0.0261695260210292 0.78052748758349 0.833333333333333 11.5 11 5 primary atelectasis 0.00559159922821187 0.0261695260210292 0.78052748758349 0.833333333333333 11.5 11 5 increased effector memory CD8-positive, alpha-beta T cell number 0.00559159922821187 0.0261695260210292 0.78052748758349 0.833333333333333 11.5 11 5 abnormal hypoglossal nerve topology 0.00559159922821187 0.0261695260210292 0.78052748758349 0.833333333333333 11.5 11 5 amyloidosis 0.0251801917116891 0.0870950212885894 0.78052748758349 0.833333333333333 11.5 11 5 abnormal superior cervical ganglion morphology 0.0251801917116891 0.0870950212885894 0.78052748758349 0.833333333333333 11.5 11 5 abnormal mating frequency 0.0251801917116891 0.0870950212885894 0.78052748758349 0.833333333333333 11.5 11 5 myocarditis 0.0251801917116891 0.0870950212885894 0.78052748758349 0.833333333333333 11.5 11 5 abnormal gastrocnemius morphology 0.0251801917116891 0.0870950212885894 0.78052748758349 0.833333333333333 11.5 11 5 dilated bile duct 0.0251801917116891 0.0870950212885894 0.78052748758349 0.833333333333333 11.5 11 5 small intestinal inflammation 0.0251801917116891 0.0870950212885894 0.78052748758349 0.833333333333333 11.5 11 5 abnormal nucleotide metabolism 0.0251801917116891 0.0870950212885894 0.78052748758349 0.833333333333333 11.5 11 5 abnormal rostral-caudal body axis extension 0.0251801917116891 0.0870950212885894 0.78052748758349 0.833333333333333 11.5 11 5 vestibular saccular macula degeneration 0.0251801917116891 0.0870950212885894 0.78052748758349 0.833333333333333 11.5 11 5 abnormal palatine bone morphology 0.0251801917116891 0.0870950212885894 0.78052748758349 0.833333333333333 11.5 11 5 hemoperitoneum 0.0251801917116891 0.0870950212885894 0.78052748758349 0.833333333333333 11.5 11 5 decreased prostaglandin level 0.0251801917116891 0.0870950212885894 0.78052748758349 0.833333333333333 11.5 11 5 increased fibrosarcoma incidence 0.0251801917116891 0.0870950212885894 0.78052748758349 0.833333333333333 11.5 11 5 persistent right dorsal aorta 0.0251801917116891 0.0870950212885894 0.78052748758349 0.833333333333333 11.5 11 5 increased type II pneumocyte number 0.0251801917116891 0.0870950212885894 0.78052748758349 0.833333333333333 11.5 11 5 abnormal colon goblet cell morphology 0.0251801917116891 0.0870950212885894 0.78052748758349 0.833333333333333 11.5 11 5 abnormal ear shape 0.125454472572077 0.294192881845367 0.78052748758349 0.833333333333333 11.5 11 5 echinocytosis 0.125454472572077 0.294192881845367 0.78052748758349 0.833333333333333 11.5 11 5 poor arterial differentiation 0.125454472572077 0.294192881845367 0.78052748758349 0.833333333333333 11.5 11 5 absent organized vascular network 0.125454472572077 0.294192881845367 0.78052748758349 0.833333333333333 11.5 11 5 hemoglobinuria 0.125454472572077 0.294192881845367 0.78052748758349 0.833333333333333 11.5 11 5 absent radius 0.125454472572077 0.294192881845367 0.78052748758349 0.833333333333333 11.5 11 5 ectopic digits 0.125454472572077 0.294192881845367 0.78052748758349 0.833333333333333 11.5 11 5 epidermal necrosis 0.125454472572077 0.294192881845367 0.78052748758349 0.833333333333333 11.5 11 5 abnormal lens induction 0.125454472572077 0.294192881845367 0.78052748758349 0.833333333333333 11.5 11 5 hyperresponsive 0.125454472572077 0.294192881845367 0.78052748758349 0.833333333333333 11.5 11 5 jumpy 0.125454472572077 0.294192881845367 0.78052748758349 0.833333333333333 11.5 11 5 abnormal avoidance learning behavior 0.125454472572077 0.294192881845367 0.78052748758349 0.833333333333333 11.5 11 5 reduced NMDA-mediated synaptic currents 0.125454472572077 0.294192881845367 0.78052748758349 0.833333333333333 11.5 11 5 abnormal gustatory system physiology 0.125454472572077 0.294192881845367 0.78052748758349 0.833333333333333 11.5 11 5 abnormal parental behavior 0.125454472572077 0.294192881845367 0.78052748758349 0.833333333333333 11.5 11 5 abnormal hepatobiliary system physiology 0.125454472572077 0.294192881845367 0.78052748758349 0.833333333333333 11.5 11 5 abnormal internal nares morphology 0.125454472572077 0.294192881845367 0.78052748758349 0.833333333333333 11.5 11 5 abnormal pulmonary alveolar duct morphology 0.125454472572077 0.294192881845367 0.78052748758349 0.833333333333333 11.5 11 5 abnormal cervical lymph node morphology 0.125454472572077 0.294192881845367 0.78052748758349 0.833333333333333 11.5 11 5 chromatolysis 0.125454472572077 0.294192881845367 0.78052748758349 0.833333333333333 11.5 11 5 abnormal otolithic membrane morphology 0.125454472572077 0.294192881845367 0.78052748758349 0.833333333333333 11.5 11 5 increased post-tetanic potentiation 0.125454472572077 0.294192881845367 0.78052748758349 0.833333333333333 11.5 11 5 ectopic thymus 0.125454472572077 0.294192881845367 0.78052748758349 0.833333333333333 11.5 11 5 liver cirrhosis 0.125454472572077 0.294192881845367 0.78052748758349 0.833333333333333 11.5 11 5 decreased posterior semicircular canal size 0.125454472572077 0.294192881845367 0.78052748758349 0.833333333333333 11.5 11 5 loss of hippocampal neurons 0.125454472572077 0.294192881845367 0.78052748758349 0.833333333333333 11.5 11 5 decreased liver function 0.125454472572077 0.294192881845367 0.78052748758349 0.833333333333333 11.5 11 5 pancreas fibrosis 0.125454472572077 0.294192881845367 0.78052748758349 0.833333333333333 11.5 11 5 increased glycerol level 0.125454472572077 0.294192881845367 0.78052748758349 0.833333333333333 11.5 11 5 short perineum 0.125454472572077 0.294192881845367 0.78052748758349 0.833333333333333 11.5 11 5 ureter obstruction 0.125454472572077 0.294192881845367 0.78052748758349 0.833333333333333 11.5 11 5 abnormal lambdoidal suture morphology 0.125454472572077 0.294192881845367 0.78052748758349 0.833333333333333 11.5 11 5 abnormal metopic suture morphology 0.125454472572077 0.294192881845367 0.78052748758349 0.833333333333333 11.5 11 5 abnormal ST segment 0.125454472572077 0.294192881845367 0.78052748758349 0.833333333333333 11.5 11 5 shortened QT interval 0.125454472572077 0.294192881845367 0.78052748758349 0.833333333333333 11.5 11 5 abnormal cholesterol level 0.125454472572077 0.294192881845367 0.78052748758349 0.833333333333333 11.5 11 5 abnormal motor nerve collateral sprouting 0.125454472572077 0.294192881845367 0.78052748758349 0.833333333333333 11.5 11 5 abnormal physical strength 0.125454472572077 0.294192881845367 0.78052748758349 0.833333333333333 11.5 11 5 vestibular saccular degeneration 0.125454472572077 0.294192881845367 0.78052748758349 0.833333333333333 11.5 11 5 short scapula 0.125454472572077 0.294192881845367 0.78052748758349 0.833333333333333 11.5 11 5 enlarged interparietal bone 0.125454472572077 0.294192881845367 0.78052748758349 0.833333333333333 11.5 11 5 absent cochlear nerve compound action potential 0.125454472572077 0.294192881845367 0.78052748758349 0.833333333333333 11.5 11 5 abnormal blastocoele morphology 0.125454472572077 0.294192881845367 0.78052748758349 0.833333333333333 11.5 11 5 variegated coat color 0.125454472572077 0.294192881845367 0.78052748758349 0.833333333333333 11.5 11 5 decreased susceptibility to fungal infection 0.125454472572077 0.294192881845367 0.78052748758349 0.833333333333333 11.5 11 5 abnormal ligament morphology 0.125454472572077 0.294192881845367 0.78052748758349 0.833333333333333 11.5 11 5 abnormal thromboxane level 0.125454472572077 0.294192881845367 0.78052748758349 0.833333333333333 11.5 11 5 absent sperm mitochondrial sheath 0.125454472572077 0.294192881845367 0.78052748758349 0.833333333333333 11.5 11 5 abnormal neural crest cell morphology 0.125454472572077 0.294192881845367 0.78052748758349 0.833333333333333 11.5 11 5 exostosis 0.125454472572077 0.294192881845367 0.78052748758349 0.833333333333333 11.5 11 5 absent tongue 0.125454472572077 0.294192881845367 0.78052748758349 0.833333333333333 11.5 11 5 increased transitional stage T1 B cell number 0.125454472572077 0.294192881845367 0.78052748758349 0.833333333333333 11.5 11 5 ectopic hippocampus pyramidal cells 0.125454472572077 0.294192881845367 0.78052748758349 0.833333333333333 11.5 11 5 abnormal orbit morphology 0.125454472572077 0.294192881845367 0.78052748758349 0.833333333333333 11.5 11 5 abnormal oval cell physiology 0.125454472572077 0.294192881845367 0.78052748758349 0.833333333333333 11.5 11 5 abnormal synaptic dopamine release 0.125454472572077 0.294192881845367 0.78052748758349 0.833333333333333 11.5 11 5 enlarged lymphatic vessel 0.125454472572077 0.294192881845367 0.78052748758349 0.833333333333333 11.5 11 5 abnormal epiglottis morphology 0.125454472572077 0.294192881845367 0.78052748758349 0.833333333333333 11.5 11 5 kidney microaneurysm 0.125454472572077 0.294192881845367 0.78052748758349 0.833333333333333 11.5 11 5 absent third pharyngeal arch 0.125454472572077 0.294192881845367 0.78052748758349 0.833333333333333 11.5 11 5 thick myocardium 0.125454472572077 0.294192881845367 0.78052748758349 0.833333333333333 11.5 11 5 persistent hyperplastic primary vitreous 0.125454472572077 0.294192881845367 0.78052748758349 0.833333333333333 11.5 11 5 abnormal intestinal enteroendocrine cell morphology 0.125454472572077 0.294192881845367 0.78052748758349 0.833333333333333 11.5 11 5 ectopic ureteric bud 0.125454472572077 0.294192881845367 0.78052748758349 0.833333333333333 11.5 11 5 abnormal ureteric bud elongation 0.125454472572077 0.294192881845367 0.78052748758349 0.833333333333333 11.5 11 5 abnormal ureteric bud tip morphology 0.125454472572077 0.294192881845367 0.78052748758349 0.833333333333333 11.5 11 5 abnormal kidney collecting duct epithelium morphology 0.125454472572077 0.294192881845367 0.78052748758349 0.833333333333333 11.5 11 5 podocyte hypertrophy 0.125454472572077 0.294192881845367 0.78052748758349 0.833333333333333 11.5 11 5 increased total retina thickness 0.125454472572077 0.294192881845367 0.78052748758349 0.833333333333333 11.5 11 5 absent midbrain 0.125454472572077 0.294192881845367 0.78052748758349 0.833333333333333 11.5 11 5 delayed limb development 0.125454472572077 0.294192881845367 0.78052748758349 0.833333333333333 11.5 11 5 abnormal Rathke's pouch development 0.125454472572077 0.294192881845367 0.78052748758349 0.833333333333333 11.5 11 5 ciliary body hypoplasia 0.125454472572077 0.294192881845367 0.78052748758349 0.833333333333333 11.5 11 5 abnormal vertebral artery origin 0.125454472572077 0.294192881845367 0.78052748758349 0.833333333333333 11.5 11 5 additional anastomosis between intracranial vertebral arteries 0.125454472572077 0.294192881845367 0.78052748758349 0.833333333333333 11.5 11 5 abnormal Wolffian duct connection 0.125454472572077 0.294192881845367 0.78052748758349 0.833333333333333 11.5 11 5 abnormal platelet alpha-granule morphology 0.125454472572077 0.294192881845367 0.78052748758349 0.833333333333333 11.5 11 5 increased body fat mass 0.125454472572077 0.294192881845367 0.78052748758349 0.833333333333333 11.5 11 5 decreased tear production 0.125454472572077 0.294192881845367 0.78052748758349 0.833333333333333 11.5 11 5 abnormal excitatory synapse morphology 0.125454472572077 0.294192881845367 0.78052748758349 0.833333333333333 11.5 11 5 increased cardiac cell glucose uptake 0.125454472572077 0.294192881845367 0.78052748758349 0.833333333333333 11.5 11 5 abnormal liver morphology 6.75773917922677e-19 5.42254071236342e-17 0.779655389832 0.832402234636871 11.5 11 5 increased tumor incidence 2.22679057154383e-13 9.98043521930683e-12 0.778009656978382 0.830645161290323 11.5 11 5 syndactyly 4.67963789147779e-07 7.55883068509806e-06 0.777881631693377 0.830508474576271 11.5 11 5 extramedullary hematopoiesis 1.32190214497525e-11 4.69747369375132e-10 0.777582100837892 0.830188679245283 11.5 11 5 decreased heart rate 5.16669691504471e-11 1.71362114348983e-09 0.777405377633156 0.83 11.5 11 5 abnormal suckling behavior 7.92414932849833e-10 2.10816272242135e-08 0.776979635367202 0.829545454545455 11.5 11 5 sparse hair 3.11087051546623e-09 7.36980038783072e-08 0.776720036424546 0.829268292682927 11.5 11 5 abnormal developmental patterning 3.11087051546623e-09 7.36980038783072e-08 0.776720036424546 0.829268292682927 11.5 11 5 abnormal cholesterol homeostasis 3.01513758120231e-05 0.000311856745664896 0.776720036424546 0.829268292682927 11.5 11 5 increased bone trabecula number 3.01513758120231e-05 0.000311856745664896 0.776720036424546 0.829268292682927 11.5 11 5 abnormal bone structure 7.9037398735565e-20 6.89843962648133e-18 0.776483303710001 0.829015544041451 11.5 11 5 abnormal axial skeleton morphology 1.22374158614956e-08 2.69385592526286e-07 0.776419448175156 0.828947368421053 11.5 11 5 preweaning lethality, incomplete penetrance 2.04431468687282e-40 1.01704655671923e-37 0.776329051219961 0.828850855745721 11.5 11 5 increased carcinoma incidence 0.000122749610044737 0.00103857025505538 0.776067330511585 0.828571428571429 11.5 11 5 abnormal midbrain development 0.000122749610044737 0.00103857025505538 0.776067330511585 0.828571428571429 11.5 11 5 increased red blood cell distribution width 0.000122749610044737 0.00103857025505538 0.776067330511585 0.828571428571429 11.5 11 5 abnormal neuron morphology 8.34607345523833e-11 2.64469525094336e-09 0.775797017961772 0.828282828282828 11.5 11 5 decreased circulating glucose level 7.79789576926422e-28 1.33774246386516e-25 0.775491826373274 0.827956989247312 11.5 11 5 hypoglycemia 3.26559596141455e-10 9.50078357195168e-09 0.775491826373274 0.827956989247312 11.5 11 5 glomerulosclerosis 7.57325224480875e-07 1.15929015132072e-05 0.775144539393259 0.827586206896552 11.5 11 5 abnormal enzyme/coenzyme level 7.57325224480875e-07 1.15929015132072e-05 0.775144539393259 0.827586206896552 11.5 11 5 abnormal spinal nerve morphology 0.00050591859878185 0.00357013479282227 0.775144539393259 0.827586206896552 11.5 11 5 aphagia 0.00050591859878185 0.00357013479282227 0.775144539393259 0.827586206896552 11.5 11 5 abnormal embryonic erythropoiesis 0.00050591859878185 0.00357013479282227 0.775144539393259 0.827586206896552 11.5 11 5 polychromatophilia 0.00050591859878185 0.00357013479282227 0.775144539393259 0.827586206896552 11.5 11 5 blood in lymph vessels 0.00050591859878185 0.00357013479282227 0.775144539393259 0.827586206896552 11.5 11 5 abnormal neurocranium morphology 1.97532279258997e-08 4.21769566228973e-07 0.774283267682823 0.826666666666667 11.5 11 5 abnormal bone mineralization 9.35730991707919e-13 3.87938473645575e-11 0.774076847190238 0.826446280991736 11.5 11 5 abnormal nervous system physiology 3.64474588810223e-12 1.38416876284798e-10 0.773740292039286 0.826086956521739 11.5 11 5 decreased spleen weight 7.7874552750433e-08 1.47310228111561e-06 0.773740292039286 0.826086956521739 11.5 11 5 perimembraneous ventricular septal defect 7.7874552750433e-08 1.47310228111561e-06 0.773740292039286 0.826086956521739 11.5 11 5 abnormal inner ear morphology 1.20958242607391e-05 0.000136455160311059 0.773740292039286 0.826086956521739 11.5 11 5 abnormal myelin sheath morphology 1.20958242607391e-05 0.000136455160311059 0.773740292039286 0.826086956521739 11.5 11 5 abnormal basicranium morphology 0.00212240953329075 0.011985229770853 0.773740292039286 0.826086956521739 11.5 11 5 abnormal motor capabilities/coordination/movement 9.94481458333981e-14 4.62387407029117e-12 0.773431783150913 0.825757575757576 11.5 11 5 perinatal lethality 4.88068366684148e-05 0.000473911014795731 0.772722212707655 0.825 11.5 11 5 abnormal myocardial fiber morphology 2.16460222415614e-10 6.41005718165285e-09 0.772480812453764 0.824742268041237 11.5 11 5 anemia 6.08792849559097e-21 6.30988422199272e-19 0.772389286291151 0.824644549763033 11.5 11 5 abnormal craniofacial bone morphology 1.22154634217184e-06 1.74631984261635e-05 0.772311408766822 0.824561403508772 11.5 11 5 increased grip strength 8.46339682180907e-10 2.22779889886244e-08 0.77195026244521 0.824175824175824 11.5 11 5 abnormal embryo development 6.6014471358603e-14 3.18856305834029e-12 0.771344811258979 0.823529411764706 11.5 11 5 overexpanded pulmonary alveoli 0.000198731189291924 0.0016102404995559 0.771344811258979 0.823529411764706 11.5 11 5 abnormal direction of heart looping 0.000198731189291924 0.0016102404995559 0.771344811258979 0.823529411764706 11.5 11 5 abnormal adipose tissue morphology 0.00915183166097763 0.0396951721999684 0.771344811258979 0.823529411764706 11.5 11 5 hydroureter 0.00915183166097763 0.0396951721999684 0.771344811258979 0.823529411764706 11.5 11 5 abnormal vagus nerve morphology 0.00915183166097763 0.0396951721999684 0.771344811258979 0.823529411764706 11.5 11 5 abnormal cranial suture morphology 0.00915183166097763 0.0396951721999684 0.771344811258979 0.823529411764706 11.5 11 5 absence seizures 0.00915183166097763 0.0396951721999684 0.771344811258979 0.823529411764706 11.5 11 5 abnormal duodenum morphology 0.00915183166097763 0.0396951721999684 0.771344811258979 0.823529411764706 11.5 11 5 abnormal ectoplacental cone morphology 0.00915183166097763 0.0396951721999684 0.771344811258979 0.823529411764706 11.5 11 5 increased hepatoma incidence 0.00915183166097763 0.0396951721999684 0.771344811258979 0.823529411764706 11.5 11 5 abnormal survival 0.00915183166097763 0.0396951721999684 0.771344811258979 0.823529411764706 11.5 11 5 kinked tail 8.90294966088389e-11 2.78567135615707e-09 0.771344811258979 0.823529411764706 11.5 11 5 impaired hematopoiesis 4.86717167551556e-06 6.03844864979799e-05 0.771344811258979 0.823529411764706 11.5 11 5 increased lung adenocarcinoma incidence 4.86717167551556e-06 6.03844864979799e-05 0.771344811258979 0.823529411764706 11.5 11 5 abnormal cervical vertebrae morphology 4.86717167551556e-06 6.03844864979799e-05 0.771344811258979 0.823529411764706 11.5 11 5 decreased total body fat amount 4.79242496895098e-32 1.32457301225173e-29 0.771179853001652 0.823353293413174 11.5 11 5 trabecula carnea hypoplasia 1.94966812696101e-05 0.000208675297633092 0.77012045441571 0.822222222222222 11.5 11 5 abnormal autopod morphology 1.94966812696101e-05 0.000208675297633092 0.77012045441571 0.822222222222222 11.5 11 5 irregular heartbeat 1.94966812696101e-05 0.000208675297633092 0.77012045441571 0.822222222222222 11.5 11 5 abnormal cell migration 1.94966812696101e-05 0.000208675297633092 0.77012045441571 0.822222222222222 11.5 11 5 small placenta 1.94966812696101e-05 0.000208675297633092 0.77012045441571 0.822222222222222 11.5 11 5 cardiomyopathy 1.94966812696101e-05 0.000208675297633092 0.77012045441571 0.822222222222222 11.5 11 5 decreased bone mineral content 2.51217797644455e-20 2.35812932694559e-18 0.770020386789097 0.822115384615385 11.5 11 5 decreased grip strength 2.68367241017561e-21 2.96694894236081e-19 0.769835330219333 0.821917808219178 11.5 11 5 short mandible 1.96355138899477e-06 2.64733554478292e-05 0.769377094903726 0.821428571428571 11.5 11 5 abnormal eye development 1.96355138899477e-06 2.64733554478292e-05 0.769377094903726 0.821428571428571 11.5 11 5 abnormal circulating cholesterol level 0.000819273245094315 0.00529335635629119 0.769377094903726 0.821428571428571 11.5 11 5 abnormal jaw morphology 0.000819273245094315 0.00529335635629119 0.769377094903726 0.821428571428571 11.5 11 5 abnormal ovulation 0.000819273245094315 0.00529335635629119 0.769377094903726 0.821428571428571 11.5 11 5 failure of blastocyst to hatch from the zona pellucida 0.000819273245094315 0.00529335635629119 0.769377094903726 0.821428571428571 11.5 11 5 enhanced coordination 0.000819273245094315 0.00529335635629119 0.769377094903726 0.821428571428571 11.5 11 5 increased bone resorption 0.000819273245094315 0.00529335635629119 0.769377094903726 0.821428571428571 11.5 11 5 impaired righting response 5.56701436718462e-10 1.53016002633942e-08 0.769024977240155 0.821052631578947 11.5 11 5 decreased birth weight 5.56701436718462e-10 1.53016002633942e-08 0.769024977240155 0.821052631578947 11.5 11 5 increased circulating alanine transaminase level 2.08227409988207e-08 4.42705711406551e-07 0.768519372389898 0.82051282051282 11.5 11 5 abnormal muscle physiology 2.17388184436967e-09 5.40753108786956e-08 0.768249527104649 0.820224719101124 11.5 11 5 reduced fertility 6.97812740411989e-14 3.33809459956697e-12 0.76817381511814 0.820143884892086 11.5 11 5 decreased circulating alkaline phosphatase level 7.81809114970457e-06 9.15176552230123e-05 0.768039047782154 0.82 11.5 11 5 abnormal axon extension 7.81809114970457e-06 9.15176552230123e-05 0.768039047782154 0.82 11.5 11 5 abnormal maternal nurturing 7.93918167204203e-07 1.20418990300028e-05 0.767731955000154 0.819672131147541 11.5 11 5 hypoactivity 4.23685780732501e-35 1.75653063262016e-32 0.767691226514478 0.819628647214854 11.5 11 5 prenatal lethality, incomplete penetrance 1.837059800015e-28 3.51514327118256e-26 0.767176359506404 0.819078947368421 11.5 11 5 insulin resistance 4.31440255213423e-13 1.85035799110929e-11 0.766336078718336 0.818181818181818 11.5 11 5 cataract 4.06649458418392e-12 1.5326371633572e-10 0.766336078718336 0.818181818181818 11.5 11 5 polyuria 3.32775405542339e-08 6.89815684405473e-07 0.766336078718336 0.818181818181818 11.5 11 5 impaired swimming 3.21622796610177e-07 5.46100141001922e-06 0.766336078718336 0.818181818181818 11.5 11 5 osteoporosis 3.1289986356823e-05 0.000321627442407426 0.766336078718336 0.818181818181818 11.5 11 5 lethality, incomplete penetrance 3.1289986356823e-05 0.000321627442407426 0.766336078718336 0.818181818181818 11.5 11 5 abnormal tooth development 0.000319977683388118 0.00244905996131675 0.766336078718336 0.818181818181818 11.5 11 5 abnormal epidermis stratum basale morphology 0.000319977683388118 0.00244905996131675 0.766336078718336 0.818181818181818 11.5 11 5 decreased systemic arterial blood pressure 0.000319977683388118 0.00244905996131675 0.766336078718336 0.818181818181818 11.5 11 5 increased cardiomyocyte apoptosis 0.000319977683388118 0.00244905996131675 0.766336078718336 0.818181818181818 11.5 11 5 head tossing 0.000319977683388118 0.00244905996131675 0.766336078718336 0.818181818181818 11.5 11 5 abnormal basisphenoid bone morphology 0.00343809914507249 0.0177433021231697 0.766336078718336 0.818181818181818 11.5 11 5 intestinal inflammation 0.00343809914507249 0.0177433021231697 0.766336078718336 0.818181818181818 11.5 11 5 intracerebral hemorrhage 0.00343809914507249 0.0177433021231697 0.766336078718336 0.818181818181818 11.5 11 5 increased skin papilloma incidence 0.00343809914507249 0.0177433021231697 0.766336078718336 0.818181818181818 11.5 11 5 aphakia 0.00343809914507249 0.0177433021231697 0.766336078718336 0.818181818181818 11.5 11 5 abnormal cochlear sensory epithelium morphology 0.00343809914507249 0.0177433021231697 0.766336078718336 0.818181818181818 11.5 11 5 decreased cardiac output 0.00343809914507249 0.0177433021231697 0.766336078718336 0.818181818181818 11.5 11 5 parakeratosis 0.00343809914507249 0.0177433021231697 0.766336078718336 0.818181818181818 11.5 11 5 pulmonary vascular congestion 0.00343809914507249 0.0177433021231697 0.766336078718336 0.818181818181818 11.5 11 5 increased circulating creatine kinase level 0.00343809914507249 0.0177433021231697 0.766336078718336 0.818181818181818 11.5 11 5 abnormal sphenoid bone morphology 0.0414123424864676 0.13097673481893 0.766336078718336 0.818181818181818 11.5 11 5 abnormal stomach epithelium morphology 0.0414123424864676 0.13097673481893 0.766336078718336 0.818181818181818 11.5 11 5 delayed hepatic development 0.0414123424864676 0.13097673481893 0.766336078718336 0.818181818181818 11.5 11 5 impaired myelopoiesis 0.0414123424864676 0.13097673481893 0.766336078718336 0.818181818181818 11.5 11 5 vasculitis 0.0414123424864676 0.13097673481893 0.766336078718336 0.818181818181818 11.5 11 5 retinal detachment 0.0414123424864676 0.13097673481893 0.766336078718336 0.818181818181818 11.5 11 5 patent ductus arteriosus 0.0414123424864676 0.13097673481893 0.766336078718336 0.818181818181818 11.5 11 5 fused joints 0.0414123424864676 0.13097673481893 0.766336078718336 0.818181818181818 11.5 11 5 pulmonary hypertension 0.0414123424864676 0.13097673481893 0.766336078718336 0.818181818181818 11.5 11 5 pathological neovascularization 0.0414123424864676 0.13097673481893 0.766336078718336 0.818181818181818 11.5 11 5 abnormal hair medulla 0.0414123424864676 0.13097673481893 0.766336078718336 0.818181818181818 11.5 11 5 abnormal crista ampullaris neuroepithelium morphology 0.0414123424864676 0.13097673481893 0.766336078718336 0.818181818181818 11.5 11 5 increased circulating triiodothyronine level 0.0414123424864676 0.13097673481893 0.766336078718336 0.818181818181818 11.5 11 5 aberrant origin of the right subclavian artery 0.0414123424864676 0.13097673481893 0.766336078718336 0.818181818181818 11.5 11 5 decreased embryonic cilium length 0.0414123424864676 0.13097673481893 0.766336078718336 0.818181818181818 11.5 11 5 chylous ascites 0.0414123424864676 0.13097673481893 0.766336078718336 0.818181818181818 11.5 11 5 reduced sympathetic cervical ganglion size 0.0414123424864676 0.13097673481893 0.766336078718336 0.818181818181818 11.5 11 5 decreased leukocyte cell number 1.7751393890563e-13 8.10212702803222e-12 0.765714557162198 0.817518248175182 11.5 11 5 abnormal definitive hematopoiesis 1.41922728110621e-09 3.62084908897609e-08 0.765420503952842 0.817204301075269 11.5 11 5 corneal opacity 1.30510844030467e-07 2.36105981473299e-06 0.765136804729731 0.816901408450704 11.5 11 5 abnormal renal glomerulus morphology 6.12059682118821e-11 1.97727072632541e-09 0.764773721779053 0.81651376146789 11.5 11 5 increased bone mineral content 6.12059682118821e-11 1.97727072632541e-09 0.764773721779053 0.81651376146789 11.5 11 5 increased circulating LDL cholesterol level 1.25080691745552e-05 0.000140215466993674 0.764598355183827 0.816326530612245 11.5 11 5 abnormal frontal bone morphology 0.0001260556758646 0.00106112857432552 0.764095329950154 0.815789473684211 11.5 11 5 abnormal gait 3.20452033862071e-28 5.90462543875482e-26 0.763856026683649 0.815533980582524 11.5 11 5 abnormal locomotor behavior 2.25830350368322e-09 5.58958205513632e-08 0.76355949872298 0.815217391304348 11.5 11 5 diluted coat color 5.01875945585307e-06 6.17354675331165e-05 0.763182432303857 0.814814814814815 11.5 11 5 abnormal mandible morphology 5.01875945585307e-06 6.17354675331165e-05 0.763182432303857 0.814814814814815 11.5 11 5 abnormal small intestine morphology 5.01875945585307e-06 6.17354675331165e-05 0.763182432303857 0.814814814814815 11.5 11 5 abnormal eye muscle morphology 0.00131797448443284 0.00799234727553344 0.763182432303857 0.814814814814815 11.5 11 5 premature death 5.89059389815165e-76 7.32642616082611e-73 0.762578074977041 0.814169570267131 11.5 11 5 abnormal homeostasis 4.99898157251761e-05 0.000479189466729771 0.762375685546665 0.813953488372093 11.5 11 5 postnatal growth retardation 5.55654931115202e-54 3.45547910287266e-51 0.762162134934467 0.813725490196078 11.5 11 5 abnormal cranium morphology 7.11639720417854e-13 2.97513244460405e-11 0.761888025193437 0.813432835820896 11.5 11 5 decreased body weight 6.33952469444608e-109 3.15391353548692e-105 0.761865441030605 0.813408723747981 11.5 11 5 delayed bone ossification 8.42949687895295e-08 1.58251875369022e-06 0.761794827881487 0.813333333333333 11.5 11 5 increased or absent threshold for auditory brainstem response 4.64648787441176e-26 7.22383661724953e-24 0.761621977503613 0.813148788927336 11.5 11 5 increased sacral vertebrae number 8.15150478208531e-07 1.22890109972347e-05 0.761014300393903 0.8125 11.5 11 5 scoliosis 0.000512193339142126 0.00358896036934095 0.761014300393903 0.8125 11.5 11 5 kidney cortex cysts 0.000512193339142126 0.00358896036934095 0.761014300393903 0.8125 11.5 11 5 neonatal lethality 0.000512193339142126 0.00358896036934095 0.761014300393903 0.8125 11.5 11 5 abnormal diaphragm morphology 0.000512193339142126 0.00358896036934095 0.761014300393903 0.8125 11.5 11 5 abnormal embryonic hematopoiesis 0.000512193339142126 0.00358896036934095 0.761014300393903 0.8125 11.5 11 5 reduced male mating frequency 0.0148313241311662 0.058699950320248 0.761014300393903 0.8125 11.5 11 5 abnormal olfaction 0.0148313241311662 0.058699950320248 0.761014300393903 0.8125 11.5 11 5 white spotting 0.0148313241311662 0.058699950320248 0.761014300393903 0.8125 11.5 11 5 increased intestinal adenocarcinoma incidence 0.0148313241311662 0.058699950320248 0.761014300393903 0.8125 11.5 11 5 abnormal epicardium morphology 0.0148313241311662 0.058699950320248 0.761014300393903 0.8125 11.5 11 5 increased pancreatic beta cell number 0.0148313241311662 0.058699950320248 0.761014300393903 0.8125 11.5 11 5 blepharitis 0.0148313241311662 0.058699950320248 0.761014300393903 0.8125 11.5 11 5 decreased circulating triiodothyronine level 0.0148313241311662 0.058699950320248 0.761014300393903 0.8125 11.5 11 5 impaired behavioral response to addictive substance 0.0148313241311662 0.058699950320248 0.761014300393903 0.8125 11.5 11 5 increased heart left ventricle size 0.0148313241311662 0.058699950320248 0.761014300393903 0.8125 11.5 11 5 embryonic lethality between somite formation and embryo turning, incomplete penetrance 0.0148313241311662 0.058699950320248 0.761014300393903 0.8125 11.5 11 5 abnormal pulmonary alveolus morphology 5.97665241548106e-10 1.6159698786423e-08 0.76043470077441 0.811881188118812 11.5 11 5 neonatal lethality, incomplete penetrance 2.48311727342795e-23 3.52957383865831e-21 0.760113691754384 0.811538461538462 11.5 11 5 increased granulocyte number 1.3358942429859e-07 2.39930464218586e-06 0.759432150081234 0.810810810810811 11.5 11 5 abnormal branching of the mammary ductal tree 0.000201023420928174 0.00161827106653344 0.759432150081234 0.810810810810811 11.5 11 5 abnormal vocalization 0.000201023420928174 0.00161827106653344 0.759432150081234 0.810810810810811 11.5 11 5 abnormal breathing pattern 0.000201023420928174 0.00161827106653344 0.759432150081234 0.810810810810811 11.5 11 5 abnormal chromosome morphology 0.000201023420928174 0.00161827106653344 0.759432150081234 0.810810810810811 11.5 11 5 alopecia 2.31506967568799e-09 5.67363134805307e-08 0.759165682660153 0.810526315789474 11.5 11 5 abnormal spleen morphology 5.77319939557686e-16 3.30134103367757e-14 0.758995694822567 0.810344827586207 11.5 11 5 enlarged heart 8.33197299023472e-21 8.12775796596426e-19 0.758995694822566 0.810344827586207 11.5 11 5 increased monocyte cell number 9.44830530618793e-10 2.47396415254131e-08 0.758672717931153 0.81 11.5 11 5 postnatal lethality, incomplete penetrance 8.10213750153545e-49 4.47868156334876e-46 0.758540797792406 0.809859154929577 11.5 11 5 perinatal lethality, incomplete penetrance 3.19823994484528e-20 2.94652661585283e-18 0.75842405430679 0.809734513274336 11.5 11 5 abnormal hair follicle morphology 1.29130457152157e-06 1.83026787558969e-05 0.758226702223962 0.80952380952381 11.5 11 5 decreased susceptibility to hepatic steatosis 1.29130457152157e-06 1.83026787558969e-05 0.758226702223962 0.80952380952381 11.5 11 5 increased circulating aspartate transaminase level 1.29130457152157e-06 1.83026787558969e-05 0.758226702223962 0.80952380952381 11.5 11 5 hydronephrosis 2.20389724697222e-08 4.64592745918933e-07 0.758226702223962 0.80952380952381 11.5 11 5 abnormal scapula morphology 0.0055235047708783 0.0261459907089624 0.758226702223962 0.80952380952381 11.5 11 5 trunk curl 0.0055235047708783 0.0261459907089624 0.758226702223962 0.80952380952381 11.5 11 5 increased keratinocyte proliferation 0.0055235047708783 0.0261459907089624 0.758226702223962 0.80952380952381 11.5 11 5 complete atrioventricular septal defect 0.0055235047708783 0.0261459907089624 0.758226702223962 0.80952380952381 11.5 11 5 increased respiratory quotient 3.16131809973061e-05 0.000324279537034222 0.757277732634195 0.808510638297872 11.5 11 5 liver inflammation 2.63983677982457e-11 9.12026943029669e-10 0.757111662955986 0.808333333333333 11.5 11 5 decreased body size 1.6542969511699e-67 1.37168788867838e-64 0.757052976678724 0.808270676691729 11.5 11 5 abnormal motor coordination/ balance 1.49030510637131e-09 3.78270356838611e-08 0.7568751394749 0.808080808080808 11.5 11 5 limb grasping 2.42065428926249e-16 1.48675988754085e-14 0.756511257196306 0.807692307692308 11.5 11 5 increased rib number 8.55876986869695e-08 1.58880149614804e-06 0.756511257196306 0.807692307692308 11.5 11 5 increased urine protein level 8.55876986869695e-08 1.58880149614804e-06 0.756511257196306 0.807692307692308 11.5 11 5 abnormal heart ventricle morphology 8.55876986869695e-08 1.58880149614804e-06 0.756511257196306 0.807692307692308 11.5 11 5 decreased kidney weight 1.26317148375539e-05 0.000141219733296248 0.756511257196306 0.807692307692308 11.5 11 5 no spontaneous movement 0.00210524114012741 0.0119017894001521 0.756511257196306 0.807692307692308 11.5 11 5 abnormal erythrocyte osmotic lysis 0.00210524114012741 0.0119017894001521 0.756511257196306 0.807692307692308 11.5 11 5 abnormal rib morphology 1.81394500615233e-12 7.21950112448628e-11 0.756244410192004 0.807407407407407 11.5 11 5 cyanosis 4.08531472265987e-17 2.74654604665309e-15 0.756136003596506 0.807291666666667 11.5 11 5 absent vitelline blood vessels 5.0664815847998e-06 6.20831179418202e-05 0.755879251133485 0.807017543859649 11.5 11 5 increased blood urea nitrogen level 3.04873661392513e-13 1.3422535092281e-11 0.755765925908428 0.806896551724138 11.5 11 5 abnormal lung morphology 4.1543701768718e-11 1.4059858251658e-09 0.755603080416959 0.80672268907563 11.5 11 5 impaired glucose tolerance 1.46371820611857e-21 1.6782922432586e-19 0.75534918153241 0.806451612903226 11.5 11 5 abnormal cranial ganglia morphology 0.000814793988948442 0.00529335635629119 0.75534918153241 0.806451612903226 11.5 11 5 abnormal object recognition memory 0.000814793988948442 0.00529335635629119 0.75534918153241 0.806451612903226 11.5 11 5 reduced male fertility 8.0734142337478e-20 6.92504065739574e-18 0.755082979177685 0.806167400881057 11.5 11 5 cardiac hypertrophy 2.34531361674535e-09 5.69167572844298e-08 0.755040875744029 0.806122448979592 11.5 11 5 reduced female fertility 3.31682725137663e-20 3.00022101374522e-18 0.754958483679893 0.806034482758621 11.5 11 5 rib fusion 8.22401221045317e-07 1.23608642740195e-05 0.754898226797167 0.805970149253731 11.5 11 5 cochlear outer hair cell degeneration 3.32526239589533e-07 5.57009441736675e-06 0.754509904664041 0.805555555555556 11.5 11 5 abnormal excitatory postsynaptic potential 5.46654373044702e-08 1.07071082909346e-06 0.753875329470883 0.804878048780488 11.5 11 5 abnormal mammary gland development 0.000125760612701031 0.00106043906472479 0.753875329470883 0.804878048780488 11.5 11 5 Leydig cell hyperplasia 0.000125760612701031 0.00106043906472479 0.753875329470883 0.804878048780488 11.5 11 5 atrial septal defect 4.99224267505233e-05 0.000479189466729771 0.753378705406673 0.804347826086957 11.5 11 5 cochlear inner hair cell degeneration 1.99168609938794e-05 0.000211723041548184 0.752979458609955 0.803921568627451 11.5 11 5 abnormal dendritic spine morphology 1.99168609938794e-05 0.000211723041548184 0.752979458609955 0.803921568627451 11.5 11 5 impaired coordination 6.60730337940507e-29 1.36963892968918e-26 0.752554826178764 0.803468208092486 11.5 11 5 increased circulating free fatty acid level 5.22196249864432e-07 8.35019489391253e-06 0.751944790855081 0.802816901408451 11.5 11 5 abnormal glucose homeostasis 9.42594212036262e-16 5.26899573582068e-14 0.751364922113338 0.802197802197802 11.5 11 5 respiratory failure 3.08714283952904e-13 1.34723996725061e-11 0.75054696157035 0.801324503311258 11.5 11 5 increased circulating HDL cholesterol level 1.49787457883832e-09 3.78270356838611e-08 0.749306388080151 0.8 11.5 11 5 abnormal eating behavior 5.02570137706777e-06 6.17354675331165e-05 0.749306388080151 0.8 11.5 11 5 abnormal joint morphology 1.25137019789329e-05 0.000140215466993674 0.749306388080151 0.8 11.5 11 5 decreased oocyte number 3.12679812739578e-05 0.000321627442407426 0.749306388080151 0.8 11.5 11 5 abnormal metabolism 7.84632067056753e-05 0.000718884812819032 0.749306388080151 0.8 11.5 11 5 lethality at weaning, complete penetrance 7.84632067056753e-05 0.000718884812819032 0.749306388080151 0.8 11.5 11 5 abnormal heart tube morphology 0.00128761186374284 0.00790831854405944 0.749306388080151 0.8 11.5 11 5 abnormal hair cycle 0.00128761186374284 0.00790831854405944 0.749306388080151 0.8 11.5 11 5 abnormal lactation 0.00128761186374284 0.00790831854405944 0.749306388080151 0.8 11.5 11 5 abnormal fat pad morphology 0.00128761186374284 0.00790831854405944 0.749306388080151 0.8 11.5 11 5 abnormal nest building behavior 0.00333714917488816 0.0176245404937034 0.749306388080151 0.8 11.5 11 5 abnormal keratinocyte physiology 0.00333714917488816 0.0176245404937034 0.749306388080151 0.8 11.5 11 5 abnormal cochlear outer hair cell morphology 0.00333714917488816 0.0176245404937034 0.749306388080151 0.8 11.5 11 5 abnormal energy expenditure 0.00333714917488816 0.0176245404937034 0.749306388080151 0.8 11.5 11 5 decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 0.00333714917488816 0.0176245404937034 0.749306388080151 0.8 11.5 11 5 small gonad 0.00879386379210103 0.0390437324983013 0.749306388080151 0.8 11.5 11 5 abnormal trachea morphology 0.00879386379210103 0.0390437324983013 0.749306388080151 0.8 11.5 11 5 decreased paired-pulse facilitation 0.00879386379210103 0.0390437324983013 0.749306388080151 0.8 11.5 11 5 decreased myocardial infarction size 0.00879386379210103 0.0390437324983013 0.749306388080151 0.8 11.5 11 5 abnormal lens epithelium morphology 0.00879386379210103 0.0390437324983013 0.749306388080151 0.8 11.5 11 5 abnormal physiological neovascularization 0.00879386379210103 0.0390437324983013 0.749306388080151 0.8 11.5 11 5 kidney atrophy 0.00879386379210103 0.0390437324983013 0.749306388080151 0.8 11.5 11 5 abnormal induced retinal neovascularization 0.00879386379210103 0.0390437324983013 0.749306388080151 0.8 11.5 11 5 abnormal heart electrocardiography waveform feature 0.00879386379210103 0.0390437324983013 0.749306388080151 0.8 11.5 11 5 absent incisors 0.0237699952209582 0.0855066711672213 0.749306388080151 0.8 11.5 11 5 abnormal enteric neuron morphology 0.0237699952209582 0.0855066711672213 0.749306388080151 0.8 11.5 11 5 abnormal prostate gland morphology 0.0237699952209582 0.0855066711672213 0.749306388080151 0.8 11.5 11 5 abnormal pup retrieval 0.0237699952209582 0.0855066711672213 0.749306388080151 0.8 11.5 11 5 audiogenic seizures 0.0237699952209582 0.0855066711672213 0.749306388080151 0.8 11.5 11 5 abnormal glial cell morphology 0.0237699952209582 0.0855066711672213 0.749306388080151 0.8 11.5 11 5 abnormal rostral migratory stream morphology 0.0237699952209582 0.0855066711672213 0.749306388080151 0.8 11.5 11 5 immune system phenotype 0.0237699952209582 0.0855066711672213 0.749306388080151 0.8 11.5 11 5 abnormal energy homeostasis 0.0237699952209582 0.0855066711672213 0.749306388080151 0.8 11.5 11 5 abnormal cerebral aqueduct morphology 0.0237699952209582 0.0855066711672213 0.749306388080151 0.8 11.5 11 5 absent chorion 0.0237699952209582 0.0855066711672213 0.749306388080151 0.8 11.5 11 5 ostium primum atrial septal defect 0.0237699952209582 0.0855066711672213 0.749306388080151 0.8 11.5 11 5 herniated liver 0.0237699952209582 0.0855066711672213 0.749306388080151 0.8 11.5 11 5 decreased brown adipose tissue mass 0.0237699952209582 0.0855066711672213 0.749306388080151 0.8 11.5 11 5 abnormal lateral semicircular canal morphology 0.0671358839535862 0.191869745621567 0.749306388080151 0.8 11.5 11 5 retarded hair growth 0.0671358839535862 0.191869745621567 0.749306388080151 0.8 11.5 11 5 absent palatine bone horizontal plate 0.0671358839535862 0.191869745621567 0.749306388080151 0.8 11.5 11 5 abnormal prostate gland epithelium morphology 0.0671358839535862 0.191869745621567 0.749306388080151 0.8 11.5 11 5 abnormal epidermis suprabasal layer morphology 0.0671358839535862 0.191869745621567 0.749306388080151 0.8 11.5 11 5 fused cornea and lens 0.0671358839535862 0.191869745621567 0.749306388080151 0.8 11.5 11 5 rhinitis 0.0671358839535862 0.191869745621567 0.749306388080151 0.8 11.5 11 5 decreased circulating parathyroid hormone level 0.0671358839535862 0.191869745621567 0.749306388080151 0.8 11.5 11 5 abnormal PNS synaptic transmission 0.0671358839535862 0.191869745621567 0.749306388080151 0.8 11.5 11 5 abnormal tibialis anterior morphology 0.0671358839535862 0.191869745621567 0.749306388080151 0.8 11.5 11 5 abnormal scala media morphology 0.0671358839535862 0.191869745621567 0.749306388080151 0.8 11.5 11 5 cochlear ganglion hypoplasia 0.0671358839535862 0.191869745621567 0.749306388080151 0.8 11.5 11 5 abnormal submandibular gland morphology 0.0671358839535862 0.191869745621567 0.749306388080151 0.8 11.5 11 5 abnormal pillar cell morphology 0.0671358839535862 0.191869745621567 0.749306388080151 0.8 11.5 11 5 abnormal hindlimb zeugopod morphology 0.0671358839535862 0.191869745621567 0.749306388080151 0.8 11.5 11 5 abnormal gas homeostasis 0.0671358839535862 0.191869745621567 0.749306388080151 0.8 11.5 11 5 abnormal placental transport 0.0671358839535862 0.191869745621567 0.749306388080151 0.8 11.5 11 5 abnormal utricular macula morphology 0.0671358839535862 0.191869745621567 0.749306388080151 0.8 11.5 11 5 abnormal corneal endothelium morphology 0.0671358839535862 0.191869745621567 0.749306388080151 0.8 11.5 11 5 ascites 0.0671358839535862 0.191869745621567 0.749306388080151 0.8 11.5 11 5 increased susceptibility to atherosclerosis 0.0671358839535862 0.191869745621567 0.749306388080151 0.8 11.5 11 5 vascular smooth muscle hyperplasia 0.0671358839535862 0.191869745621567 0.749306388080151 0.8 11.5 11 5 increased platelet aggregation 0.0671358839535862 0.191869745621567 0.749306388080151 0.8 11.5 11 5 ventricular premature beat 0.0671358839535862 0.191869745621567 0.749306388080151 0.8 11.5 11 5 abnormal sperm principal piece morphology 0.0671358839535862 0.191869745621567 0.749306388080151 0.8 11.5 11 5 protruding tongue 0.0671358839535862 0.191869745621567 0.749306388080151 0.8 11.5 11 5 abnormal hippocampus neuron morphology 0.0671358839535862 0.191869745621567 0.749306388080151 0.8 11.5 11 5 abnormal cerebellar granule cell migration 0.0671358839535862 0.191869745621567 0.749306388080151 0.8 11.5 11 5 acanthocytosis 0.0671358839535862 0.191869745621567 0.749306388080151 0.8 11.5 11 5 abnormal vibrissa follicle morphology 0.0671358839535862 0.191869745621567 0.749306388080151 0.8 11.5 11 5 abnormal heart and great artery attachment 0.0671358839535862 0.191869745621567 0.749306388080151 0.8 11.5 11 5 thick aortic valve cusps 0.0671358839535862 0.191869745621567 0.749306388080151 0.8 11.5 11 5 thick aortic valve 0.0671358839535862 0.191869745621567 0.749306388080151 0.8 11.5 11 5 decreased macrophage cytokine production 0.0671358839535862 0.191869745621567 0.749306388080151 0.8 11.5 11 5 lethality during fetal growth through weaning, complete penetrance 0.0671358839535862 0.191869745621567 0.749306388080151 0.8 11.5 11 5 ovary cysts 0.000502657506280679 0.00357013479282227 0.749306388080151 0.8 11.5 11 5 impaired adaptive thermogenesis 0.000502657506280679 0.00357013479282227 0.749306388080151 0.8 11.5 11 5 cachexia 2.33397208569614e-09 5.69167572844298e-08 0.747505170801112 0.798076923076923 11.5 11 5 increased mean corpuscular hemoglobin 5.7225972327227e-09 1.31805190892571e-07 0.747414200231464 0.797979797979798 11.5 11 5 increased startle reflex 3.45056657112034e-08 7.12305754826709e-07 0.747201594855206 0.797752808988764 11.5 11 5 respiratory distress 1.35526875618608e-14 6.88006332859772e-13 0.747140762681075 0.797687861271676 11.5 11 5 decreased bone mineral density 1.4843187679071e-21 1.6782922432586e-19 0.746489446771579 0.796992481203007 11.5 11 5 abnormal osteoclast physiology 3.15929370682657e-06 4.07188761436844e-05 0.746379410001713 0.796875 11.5 11 5 abnormal tooth morphology 3.15929370682657e-06 4.07188761436844e-05 0.746379410001713 0.796875 11.5 11 5 increased hemoglobin content 7.84645603226138e-06 9.16340815974186e-05 0.746131361012014 0.796610169491525 11.5 11 5 abnormal long bone epiphyseal plate proliferative zone 1.95462690848283e-05 0.000208675297633092 0.745837377024224 0.796296296296296 11.5 11 5 decreased platelet aggregation 1.95462690848283e-05 0.000208675297633092 0.745837377024224 0.796296296296296 11.5 11 5 increased T cell derived lymphoma incidence 4.88676081588362e-05 0.000473911014795731 0.745483396304232 0.795918367346939 11.5 11 5 abnormal respiratory system physiology 4.88676081588362e-05 0.000473911014795731 0.745483396304232 0.795918367346939 11.5 11 5 decreased urine osmolality 4.88676081588362e-05 0.000473911014795731 0.745483396304232 0.795918367346939 11.5 11 5 decreased circulating creatinine level 4.88676081588362e-05 0.000473911014795731 0.745483396304232 0.795918367346939 11.5 11 5 increased T cell number 5.36420182015351e-08 1.06322326913401e-06 0.745048965420604 0.795454545454545 11.5 11 5 hypertension 0.000122711374379882 0.00103857025505538 0.745048965420604 0.795454545454545 11.5 11 5 abnormal cornea morphology 3.25069626303415e-07 5.50075303013432e-06 0.744503142002714 0.794871794871795 11.5 11 5 failure of heart looping 0.000309820786829363 0.00239490547386741 0.744503142002714 0.794871794871795 11.5 11 5 seminiferous tubule degeneration 8.0209566594894e-07 1.21289542191367e-05 0.744174152545355 0.794520547945205 11.5 11 5 decreased osteoblast cell number 0.000787642732044862 0.00516492969164513 0.743796782285444 0.794117647058823 11.5 11 5 thrombocytosis 1.22020207993594e-05 0.000137341749947541 0.742846850251874 0.793103448275862 11.5 11 5 abnormal middle ear morphology 0.00202046605595877 0.0115265382341812 0.742846850251874 0.793103448275862 11.5 11 5 retinal degeneration 2.13380089070002e-08 4.5173018856309e-07 0.741501113204316 0.791666666666667 11.5 11 5 abnormal phalanx morphology 7.6015412425747e-05 0.00069903267434028 0.741501113204316 0.791666666666667 11.5 11 5 abnormal malleus morphology 0.00524641654123199 0.0252214835703605 0.741501113204316 0.791666666666667 11.5 11 5 abnormal foregut morphology 0.00524641654123199 0.0252214835703605 0.741501113204316 0.791666666666667 11.5 11 5 abnormal adrenal gland morphology 0.00524641654123199 0.0252214835703605 0.741501113204316 0.791666666666667 11.5 11 5 abnormal body weight 0.00524641654123199 0.0252214835703605 0.741501113204316 0.791666666666667 11.5 11 5 abnormal nursing 0.00524641654123199 0.0252214835703605 0.741501113204316 0.791666666666667 11.5 11 5 abnormal startle reflex 0.00524641654123199 0.0252214835703605 0.741501113204316 0.791666666666667 11.5 11 5 abnormal primitive streak formation 0.00524641654123199 0.0252214835703605 0.741501113204316 0.791666666666667 11.5 11 5 hypopigmentation 0.00524641654123199 0.0252214835703605 0.741501113204316 0.791666666666667 11.5 11 5 enlarged spleen 2.35601540425394e-22 2.93029415904083e-20 0.741501113204316 0.791666666666667 11.5 11 5 increased thermal nociceptive threshold 5.23481738702237e-08 1.04172866001745e-06 0.741072251947402 0.791208791208791 11.5 11 5 internal hemorrhage 3.07214771932223e-06 3.98029962925319e-05 0.740918630004627 0.791044776119403 11.5 11 5 abnormal left-right axis patterning 0.000190919812223494 0.00155454347923385 0.740593523102475 0.790697674418605 11.5 11 5 decreased heart weight 3.16116722877661e-07 5.40440101826928e-06 0.740055691931013 0.790123456790123 11.5 11 5 hyperactivity 5.40582791530473e-28 9.60499781380038e-26 0.739712842680203 0.789757412398922 11.5 11 5 increased bone marrow cell number 0.000482152464916581 0.00344642027724136 0.739447093500149 0.789473684210526 11.5 11 5 hyporesponsive to tactile stimuli 0.000482152464916581 0.00344642027724136 0.739447093500149 0.789473684210526 11.5 11 5 small superior vagus ganglion 0.0138620046791098 0.0558195610770793 0.739447093500149 0.789473684210526 11.5 11 5 shiny skin 0.0138620046791098 0.0558195610770793 0.739447093500149 0.789473684210526 11.5 11 5 abnormal neurotransmitter level 0.0138620046791098 0.0558195610770793 0.739447093500149 0.789473684210526 11.5 11 5 decreased germ cell number 0.0138620046791098 0.0558195610770793 0.739447093500149 0.789473684210526 11.5 11 5 abnormal neural crest cell migration 0.0138620046791098 0.0558195610770793 0.739447093500149 0.789473684210526 11.5 11 5 eyelids fail to open 0.0138620046791098 0.0558195610770793 0.739447093500149 0.789473684210526 11.5 11 5 postnatal lethality 2.86301023100366e-13 1.27173891957529e-11 0.739150126795932 0.789156626506024 11.5 11 5 thin ventricular wall 8.07278162855757e-08 1.52129123492704e-06 0.738899354912371 0.788888888888889 11.5 11 5 abnormal snout morphology 4.70705875765469e-05 0.000464635264272462 0.738499084405918 0.788461538461538 11.5 11 5 circling 1.98172918123745e-07 3.44723869813158e-06 0.738287176490737 0.788235294117647 11.5 11 5 abnormal aorta morphology 0.0012261372033713 0.00757768023201515 0.737953260988027 0.787878787878788 11.5 11 5 dextrocardia 0.0012261372033713 0.00757768023201515 0.737953260988027 0.787878787878788 11.5 11 5 decreased brown adipose tissue amount 0.0012261372033713 0.00757768023201515 0.737953260988027 0.787878787878788 11.5 11 5 decreased sensitivity to xenobiotic induced morbidity/mortality 0.0012261372033713 0.00757768023201515 0.737953260988027 0.787878787878788 11.5 11 5 myeloid hyperplasia 0.0012261372033713 0.00757768023201515 0.737953260988027 0.787878787878788 11.5 11 5 abnormal tibia morphology 0.000117666636037426 0.0010180721987586 0.737349371249084 0.787234042553192 11.5 11 5 hepatic necrosis 0.000117666636037426 0.0010180721987586 0.737349371249084 0.787234042553192 11.5 11 5 abnormal long bone morphology 1.17419669587928e-05 0.000133066709840533 0.737022676800148 0.786885245901639 11.5 11 5 abnormal limb morphology 1.19860152865296e-06 1.71845608214653e-05 0.736817948278815 0.786666666666667 11.5 11 5 shortened head 0.00314654569534075 0.0167602407219703 0.735925916864434 0.785714285714286 11.5 11 5 absent corpus callosum 0.00314654569534075 0.0167602407219703 0.735925916864434 0.785714285714286 11.5 11 5 megacephaly 0.0376213101065407 0.12075226953551 0.735925916864434 0.785714285714286 11.5 11 5 absent otoliths 0.0376213101065407 0.12075226953551 0.735925916864434 0.785714285714286 11.5 11 5 abnormal ventral body wall morphology 0.0376213101065407 0.12075226953551 0.735925916864434 0.785714285714286 11.5 11 5 abnormal voluntary movement 0.0376213101065407 0.12075226953551 0.735925916864434 0.785714285714286 11.5 11 5 abnormal uterus development 0.0376213101065407 0.12075226953551 0.735925916864434 0.785714285714286 11.5 11 5 abnormal maternal decidual layer morphology 0.0376213101065407 0.12075226953551 0.735925916864434 0.785714285714286 11.5 11 5 abnormal squamosal bone morphology 0.0376213101065407 0.12075226953551 0.735925916864434 0.785714285714286 11.5 11 5 premature hair loss 0.0376213101065407 0.12075226953551 0.735925916864434 0.785714285714286 11.5 11 5 increased circulating growth hormone level 0.0376213101065407 0.12075226953551 0.735925916864434 0.785714285714286 11.5 11 5 spina bifida occulta 0.0376213101065407 0.12075226953551 0.735925916864434 0.785714285714286 11.5 11 5 increased lung compliance 0.0376213101065407 0.12075226953551 0.735925916864434 0.785714285714286 11.5 11 5 decreased compact bone area 0.0376213101065407 0.12075226953551 0.735925916864434 0.785714285714286 11.5 11 5 multiple persisting craniopharyngeal ducts 0.0376213101065407 0.12075226953551 0.735925916864434 0.785714285714286 11.5 11 5 abnormal vitelline vein topology 0.0376213101065407 0.12075226953551 0.735925916864434 0.785714285714286 11.5 11 5 decreased response to antigen 0.0376213101065407 0.12075226953551 0.735925916864434 0.785714285714286 11.5 11 5 thick epidermis 2.95417575658041e-06 3.84738858350459e-05 0.735925916864434 0.785714285714286 11.5 11 5 dehydration 2.95417575658041e-06 3.84738858350459e-05 0.735925916864434 0.785714285714286 11.5 11 5 abnormal cartilage morphology 0.000295431289571154 0.00228936240750233 0.735925916864434 0.785714285714286 11.5 11 5 abnormal optic nerve morphology 0.000295431289571154 0.00228936240750233 0.735925916864434 0.785714285714286 11.5 11 5 abnormal spatial learning 1.03394298159573e-12 4.21242127765377e-11 0.735515472962111 0.785276073619632 11.5 11 5 neonatal lethality, complete penetrance 6.22677085964706e-33 1.98148307000719e-30 0.735339054091815 0.785087719298246 11.5 11 5 abnormal gluconeogenesis 7.25447822924254e-05 0.000672086204664462 0.734614105960932 0.784313725490196 11.5 11 5 impaired skeletal muscle contractility 0.000745775245815819 0.00490771408456839 0.734117745078526 0.783783783783784 11.5 11 5 increased insulin secretion 0.000745775245815819 0.00490771408456839 0.734117745078526 0.783783783783784 11.5 11 5 increased trabecular bone volume 0.000745775245815819 0.00490771408456839 0.734117745078526 0.783783783783784 11.5 11 5 abnormal heart morphology 3.39612873000994e-17 2.3618638238098e-15 0.73389857274084 0.783549783549784 11.5 11 5 abnormal skeleton morphology 3.20302685902289e-09 7.5521604851369e-08 0.733017118774061 0.782608695652174 11.5 11 5 abnormal epidermal layer morphology 4.53009420053483e-06 5.67688127145108e-05 0.733017118774061 0.782608695652174 11.5 11 5 increased lymphocyte cell number 4.53009420053483e-06 5.67688127145108e-05 0.733017118774061 0.782608695652174 11.5 11 5 fragile skeleton 0.00817458174748675 0.0367376189645407 0.733017118774061 0.782608695652174 11.5 11 5 conjunctivitis 0.00817458174748675 0.0367376189645407 0.733017118774061 0.782608695652174 11.5 11 5 abnormal sacral vertebrae morphology 0.00817458174748675 0.0367376189645407 0.733017118774061 0.782608695652174 11.5 11 5 abnormal Wolffian duct morphology 0.00817458174748675 0.0367376189645407 0.733017118774061 0.782608695652174 11.5 11 5 dilated heart 0.00817458174748675 0.0367376189645407 0.733017118774061 0.782608695652174 11.5 11 5 abnormal B cell morphology 0.00817458174748675 0.0367376189645407 0.733017118774061 0.782608695652174 11.5 11 5 abnormal ulna morphology 0.00817458174748675 0.0367376189645407 0.733017118774061 0.782608695652174 11.5 11 5 abnormal cardiovascular system physiology 2.12747281318527e-10 6.33783068598606e-09 0.732404740228719 0.781954887218045 11.5 11 5 decreased circulating calcium level 4.47463012142869e-05 0.000444337023036083 0.732276697441965 0.781818181818182 11.5 11 5 abnormal rostral-caudal axis patterning 4.47463012142869e-05 0.000444337023036083 0.732276697441965 0.781818181818182 11.5 11 5 decreased caudal vertebrae number 1.11740974943286e-05 0.000127210835318729 0.731744519609522 0.78125 11.5 11 5 abnormal vertebral body morphology 0.00189551059539956 0.0109271902805479 0.731744519609522 0.78125 11.5 11 5 increased circulating follicle stimulating hormone level 0.00189551059539956 0.0109271902805479 0.731744519609522 0.78125 11.5 11 5 abnormal lymphatic vessel morphology 0.00189551059539956 0.0109271902805479 0.731744519609522 0.78125 11.5 11 5 abnormal heart atrium morphology 0.00189551059539956 0.0109271902805479 0.731744519609522 0.78125 11.5 11 5 abnormal spongiotrophoblast layer morphology 0.00189551059539956 0.0109271902805479 0.731744519609522 0.78125 11.5 11 5 abnormal auditory brainstem response waveform shape 0.00189551059539956 0.0109271902805479 0.731744519609522 0.78125 11.5 11 5 scaly skin 0.000454553952385927 0.00330132250090509 0.73103062251722 0.780487804878049 11.5 11 5 hemopericardium 0.000454553952385927 0.00330132250090509 0.73103062251722 0.780487804878049 11.5 11 5 lethality at weaning, incomplete penetrance 0.000454553952385927 0.00330132250090509 0.73103062251722 0.780487804878049 11.5 11 5 testicular atrophy 0.000111266285296133 0.000972846694812413 0.730573728378147 0.78 11.5 11 5 abnormal circulating protein level 0.000111266285296133 0.000972846694812413 0.730573728378147 0.78 11.5 11 5 decreased respiratory quotient 0.000111266285296133 0.000972846694812413 0.730573728378147 0.78 11.5 11 5 postnatal lethality, complete penetrance 5.40311160838098e-27 8.96016008389847e-25 0.730379607552219 0.77979274611399 11.5 11 5 decreased circulating alanine transaminase level 6.9209726798944e-06 8.22271115847537e-05 0.730022767798676 0.779411764705882 11.5 11 5 increased circulating triglyceride level 5.24471312499066e-11 1.72797667528666e-09 0.729927774595319 0.779310344827586 11.5 11 5 increased spleen weight 7.43032721296961e-09 1.68793962943031e-07 0.72941329813112 0.778761061946903 11.5 11 5 increased circulating cholesterol level 5.70681398538125e-13 2.42661534848476e-11 0.729083630447306 0.778409090909091 11.5 11 5 increased cell proliferation 6.83889064653582e-05 0.00063953911591195 0.728492321744591 0.777777777777778 11.5 11 5 abnormal cell adhesion 6.83889064653582e-05 0.00063953911591195 0.728492321744591 0.777777777777778 11.5 11 5 abnormal reflex 0.00114613218077515 0.00719042572428295 0.728492321744591 0.777777777777778 11.5 11 5 abnormal limb bone morphology 0.00114613218077515 0.00719042572428295 0.728492321744591 0.777777777777778 11.5 11 5 abnormal fetal cardiomyocyte proliferation 0.00486067443505843 0.0242546191719315 0.728492321744591 0.777777777777778 11.5 11 5 thick interventricular septum 0.00486067443505843 0.0242546191719315 0.728492321744591 0.777777777777778 11.5 11 5 lowered ear position 0.0216126451756579 0.0791191388880779 0.728492321744591 0.777777777777778 11.5 11 5 abnormal radius morphology 0.0216126451756579 0.0791191388880779 0.728492321744591 0.777777777777778 11.5 11 5 abnormal mammary gland morphology 0.0216126451756579 0.0791191388880779 0.728492321744591 0.777777777777778 11.5 11 5 absent spleen 0.0216126451756579 0.0791191388880779 0.728492321744591 0.777777777777778 11.5 11 5 abnormal thymus cortex morphology 0.0216126451756579 0.0791191388880779 0.728492321744591 0.777777777777778 11.5 11 5 abnormal metacarpal bone morphology 0.0216126451756579 0.0791191388880779 0.728492321744591 0.777777777777778 11.5 11 5 increased circulating renin level 0.0216126451756579 0.0791191388880779 0.728492321744591 0.777777777777778 11.5 11 5 abnormal body wall morphology 0.0216126451756579 0.0791191388880779 0.728492321744591 0.777777777777778 11.5 11 5 absent ureter 0.0216126451756579 0.0791191388880779 0.728492321744591 0.777777777777778 11.5 11 5 abnormal pregnancy 0.0216126451756579 0.0791191388880779 0.728492321744591 0.777777777777778 11.5 11 5 increased gastrointestinal tumor incidence 0.0216126451756579 0.0791191388880779 0.728492321744591 0.777777777777778 11.5 11 5 abnormal head movements 0.106993710809822 0.268023016756729 0.728492321744591 0.777777777777778 11.5 11 5 crypts of Lieberkuhn abscesses 0.106993710809822 0.268023016756729 0.728492321744591 0.777777777777778 11.5 11 5 renal tubular acidosis 0.106993710809822 0.268023016756729 0.728492321744591 0.777777777777778 11.5 11 5 abnormal urinary bladder urothelium morphology 0.106993710809822 0.268023016756729 0.728492321744591 0.777777777777778 11.5 11 5 absent parathyroid glands 0.106993710809822 0.268023016756729 0.728492321744591 0.777777777777778 11.5 11 5 abnormal geniculate ganglion morphology 0.106993710809822 0.268023016756729 0.728492321744591 0.777777777777778 11.5 11 5 wavy vibrissae 0.106993710809822 0.268023016756729 0.728492321744591 0.777777777777778 11.5 11 5 abnormal kindling response 0.106993710809822 0.268023016756729 0.728492321744591 0.777777777777778 11.5 11 5 abnormal germ cell morphology 0.106993710809822 0.268023016756729 0.728492321744591 0.777777777777778 11.5 11 5 abnormal laryngeal cartilage morphology 0.106993710809822 0.268023016756729 0.728492321744591 0.777777777777778 11.5 11 5 long gestation period 0.106993710809822 0.268023016756729 0.728492321744591 0.777777777777778 11.5 11 5 abnormal lens capsule morphology 0.106993710809822 0.268023016756729 0.728492321744591 0.777777777777778 11.5 11 5 premature neuronal precursor differentiation 0.106993710809822 0.268023016756729 0.728492321744591 0.777777777777778 11.5 11 5 decreased fear-related response 0.106993710809822 0.268023016756729 0.728492321744591 0.777777777777778 11.5 11 5 short frontal bone 0.106993710809822 0.268023016756729 0.728492321744591 0.777777777777778 11.5 11 5 abnormal hair cell mechanoelectric transduction 0.106993710809822 0.268023016756729 0.728492321744591 0.777777777777778 11.5 11 5 abnormal CNS synapse formation 0.106993710809822 0.268023016756729 0.728492321744591 0.777777777777778 11.5 11 5 abnormal gallbladder physiology 0.106993710809822 0.268023016756729 0.728492321744591 0.777777777777778 11.5 11 5 decreased thyroid-stimulating hormone level 0.106993710809822 0.268023016756729 0.728492321744591 0.777777777777778 11.5 11 5 decreased susceptibility to atherosclerosis 0.106993710809822 0.268023016756729 0.728492321744591 0.777777777777778 11.5 11 5 abnormal leukopoiesis 0.106993710809822 0.268023016756729 0.728492321744591 0.777777777777778 11.5 11 5 abnormal hyoid bone lesser horn morphology 0.106993710809822 0.268023016756729 0.728492321744591 0.777777777777778 11.5 11 5 abnormal ventricle myocardium morphology 0.106993710809822 0.268023016756729 0.728492321744591 0.777777777777778 11.5 11 5 shortened ST segment 0.106993710809822 0.268023016756729 0.728492321744591 0.777777777777778 11.5 11 5 decreased pancreatic beta cell proliferation 0.106993710809822 0.268023016756729 0.728492321744591 0.777777777777778 11.5 11 5 abnormal ductus venosus valve topology 0.106993710809822 0.268023016756729 0.728492321744591 0.777777777777778 11.5 11 5 abnormal coronary sinus connection 0.106993710809822 0.268023016756729 0.728492321744591 0.777777777777778 11.5 11 5 increased exploration in new environment 1.08530661486063e-06 1.56959314213128e-05 0.728492321744591 0.777777777777778 11.5 11 5 improved glucose tolerance 5.51862567025073e-14 2.69168261857818e-12 0.726368437424636 0.775510204081633 11.5 11 5 increased fluid intake 0.000169798736256893 0.00140323706458146 0.726368437424636 0.775510204081633 11.5 11 5 abnormal retinal pigment epithelium morphology 1.64702896107127e-06 2.28244264103887e-05 0.725890563452646 0.775 11.5 11 5 atelectasis 6.51065812401527e-06 7.80494558240384e-05 0.72556076310578 0.774647887323944 11.5 11 5 abnormal skeletal muscle fiber morphology 6.51065812401527e-06 7.80494558240384e-05 0.72556076310578 0.774647887323944 11.5 11 5 absent mature ovarian follicles 0.00290870172018081 0.0157291207151082 0.725135214271114 0.774193548387097 11.5 11 5 decreased thymus weight 0.00290870172018081 0.0157291207151082 0.725135214271114 0.774193548387097 11.5 11 5 decreased exploration in new environment 1.02122087395762e-06 1.49869435042453e-05 0.72477552418467 0.773809523809524 11.5 11 5 abnormal coat/ hair morphology 0.000104027784412107 0.000927487862814038 0.724565139417127 0.773584905660377 11.5 11 5 decreased lymphocyte cell number 1.70835391550844e-09 4.27088478877111e-08 0.724427074413427 0.7734375 11.5 11 5 muscular atrophy 0.000422828500891775 0.00308796258371439 0.723761852122873 0.772727272727273 11.5 11 5 cochlear hair cell degeneration 0.000422828500891775 0.00308796258371439 0.723761852122873 0.772727272727273 11.5 11 5 increased body size 0.012613883898618 0.052208046918157 0.723761852122873 0.772727272727273 11.5 11 5 abnormal germ layer development 0.012613883898618 0.052208046918157 0.723761852122873 0.772727272727273 11.5 11 5 abnormal chorion morphology 0.012613883898618 0.052208046918157 0.723761852122873 0.772727272727273 11.5 11 5 abnormal tracheal cartilage morphology 0.012613883898618 0.052208046918157 0.723761852122873 0.772727272727273 11.5 11 5 abnormal limb posture 0.012613883898618 0.052208046918157 0.723761852122873 0.772727272727273 11.5 11 5 failure of palatal shelf elevation 0.012613883898618 0.052208046918157 0.723761852122873 0.772727272727273 11.5 11 5 increased bone volume 0.012613883898618 0.052208046918157 0.723761852122873 0.772727272727273 11.5 11 5 abnormal skin morphology 1.59680304935064e-05 0.000176144017084688 0.723761852122873 0.772727272727273 11.5 11 5 hunched posture 2.49106376807136e-06 3.28727911038595e-05 0.723222937862171 0.772151898734177 11.5 11 5 small testis 1.45236022786119e-18 1.14690351327134e-16 0.722836325457754 0.771739130434783 11.5 11 5 decreased circulating thyroxine level 0.00174946786899899 0.0103001214772426 0.722545445648717 0.771428571428571 11.5 11 5 decreased bone volume 0.00174946786899899 0.0103001214772426 0.722545445648717 0.771428571428571 11.5 11 5 abnormal lipid level 1.54193247970248e-06 2.14877145280668e-05 0.722223024655567 0.771084337349398 11.5 11 5 abnormal osteoclast morphology 0.000257766206367616 0.00202909315930204 0.721987926014729 0.770833333333333 11.5 11 5 abnormal vertebrae morphology 3.8836096219583e-08 7.98386688811675e-07 0.721808905948769 0.770642201834862 11.5 11 5 increased heart weight 6.23080566681701e-10 1.6755815239143e-08 0.721005247523167 0.76978417266187 11.5 11 5 decreased startle reflex 1.50156515110771e-08 3.26213389814885e-07 0.72048691161553 0.769230769230769 11.5 11 5 abnormal hair growth 0.000157458764678688 0.00130559559046079 0.720486911615529 0.769230769230769 11.5 11 5 increased vascular permeability 0.00105659139187398 0.00664543890590775 0.720486911615529 0.769230769230769 11.5 11 5 decreased B-1 B cell number 0.00105659139187398 0.00664543890590775 0.720486911615529 0.769230769230769 11.5 11 5 increased susceptibility to otitis media 0.00744350929075734 0.0345120770936792 0.720486911615529 0.769230769230769 11.5 11 5 abnormal membranous labyrinth morphology 0.0587013636584716 0.173729496847648 0.720486911615529 0.769230769230769 11.5 11 5 uterus hypoplasia 0.0587013636584716 0.173729496847648 0.720486911615529 0.769230769230769 11.5 11 5 abnormal digestion 0.0587013636584716 0.173729496847648 0.720486911615529 0.769230769230769 11.5 11 5 increased pituitary adenoma incidence 0.0587013636584716 0.173729496847648 0.720486911615529 0.769230769230769 11.5 11 5 abnormal otolith morphology 0.0587013636584716 0.173729496847648 0.720486911615529 0.769230769230769 11.5 11 5 muscle fatigue 0.0587013636584716 0.173729496847648 0.720486911615529 0.769230769230769 11.5 11 5 abnormal vestibulocochlear ganglion morphology 0.0587013636584716 0.173729496847648 0.720486911615529 0.769230769230769 11.5 11 5 small otic vesicle 0.0587013636584716 0.173729496847648 0.720486911615529 0.769230769230769 11.5 11 5 abnormal vertebral arch development 0.0587013636584716 0.173729496847648 0.720486911615529 0.769230769230769 11.5 11 5 increased circulating ammonia level 0.0587013636584716 0.173729496847648 0.720486911615529 0.769230769230769 11.5 11 5 increased circulating thyroxine level 0.0587013636584716 0.173729496847648 0.720486911615529 0.769230769230769 11.5 11 5 increased renin activity 0.0587013636584716 0.173729496847648 0.720486911615529 0.769230769230769 11.5 11 5 increased inflammatory response 3.66588264119632e-07 6.0792553799839e-06 0.719728504340145 0.768421052631579 11.5 11 5 hyperkeratosis 1.48407576427731e-05 0.000164438238914914 0.719442727685652 0.768115942028985 11.5 11 5 decreased bone marrow cell number 9.14417200386657e-06 0.000105795943533107 0.718512974871377 0.767123287671233 11.5 11 5 female infertility 2.64706098733362e-17 1.88130405885496e-15 0.718320033685859 0.766917293233083 11.5 11 5 muscular ventricular septal defect 5.90564984003839e-05 0.000563927216011343 0.718085288576811 0.766666666666667 11.5 11 5 delayed eyelid opening 0.00442841554466821 0.0222314503882183 0.718085288576811 0.766666666666667 11.5 11 5 abnormal response to new environment 0.00442841554466821 0.0222314503882183 0.718085288576811 0.766666666666667 11.5 11 5 disorganized myocardium 0.00442841554466821 0.0222314503882183 0.718085288576811 0.766666666666667 11.5 11 5 abnormal cellular respiration 0.00442841554466821 0.0222314503882183 0.718085288576811 0.766666666666667 11.5 11 5 short maxilla 0.00265124423518221 0.0143994978930475 0.716248753311909 0.764705882352941 11.5 11 5 increased incidence of corneal inflammation 0.0332896746592787 0.113435706458844 0.716248753311909 0.764705882352941 11.5 11 5 hyperlipidemia 0.0332896746592787 0.113435706458844 0.716248753311909 0.764705882352941 11.5 11 5 abnormal glutamate-mediated receptor currents 0.0332896746592787 0.113435706458844 0.716248753311909 0.764705882352941 11.5 11 5 abnormal testis development 0.0332896746592787 0.113435706458844 0.716248753311909 0.764705882352941 11.5 11 5 common atrium 0.0332896746592787 0.113435706458844 0.716248753311909 0.764705882352941 11.5 11 5 abnormal electroretinogram waveform feature 0.0332896746592787 0.113435706458844 0.716248753311909 0.764705882352941 11.5 11 5 abnormal neuromuscular synapse morphology 1.37024709556323e-05 0.000152505129763469 0.715483530284866 0.763888888888889 11.5 11 5 abnormal contextual conditioning behavior 0.000144772708045744 0.00120241105597258 0.71524700680378 0.763636363636364 11.5 11 5 abnormal platelet physiology 0.000144772708045744 0.00120241105597258 0.71524700680378 0.763636363636364 11.5 11 5 seizures 5.02434645768165e-08 1.00386038662515e-06 0.714798857050144 0.763157894736842 11.5 11 5 abnormal colon morphology 8.85572173468879e-05 0.000803963788870013 0.714381090330652 0.76271186440678 11.5 11 5 abnormal thoracic vertebrae morphology 8.85572173468879e-05 0.000803963788870013 0.714381090330652 0.76271186440678 11.5 11 5 abnormal retina morphology 1.86343717470028e-13 8.42781813103082e-12 0.713625131504905 0.761904761904762 11.5 11 5 abnormal vibrissa morphology 0.000963746473393203 0.00620263739344267 0.713625131504905 0.761904761904762 11.5 11 5 abnormal salivary gland morphology 0.0192590126600138 0.0714493571838694 0.713625131504905 0.761904761904762 11.5 11 5 increased incidence of induced tumors 0.0192590126600138 0.0714493571838694 0.713625131504905 0.761904761904762 11.5 11 5 left pulmonary isomerism 0.0192590126600138 0.0714493571838694 0.713625131504905 0.761904761904762 11.5 11 5 abnormal erythrocyte physiology 0.0192590126600138 0.0714493571838694 0.713625131504905 0.761904761904762 11.5 11 5 increased bone ossification 0.0192590126600138 0.0714493571838694 0.713625131504905 0.761904761904762 11.5 11 5 decreased litter size 1.83307733115865e-17 1.34111172389916e-15 0.71330768260299 0.761565836298932 11.5 11 5 azoospermia 1.79847085385614e-10 5.45572713288676e-09 0.712783592434735 0.761006289308176 11.5 11 5 abnormal spermatogenesis 7.03749131361922e-12 2.5743764180335e-10 0.712655532141448 0.760869565217391 11.5 11 5 kidney inflammation 0.000355151497632629 0.00269510412021794 0.711841068676143 0.76 11.5 11 5 abnormal inner ear vestibule morphology 0.0112924298679873 0.0470517911166139 0.711841068676143 0.76 11.5 11 5 increased pre-B cell number 0.0112924298679873 0.0470517911166139 0.711841068676143 0.76 11.5 11 5 decreased B cell proliferation 7.7447181326846e-06 9.10874059340565e-05 0.711366824126725 0.759493670886076 11.5 11 5 abnormal cochlea morphology 0.000216427322551855 0.0017338581798639 0.711147266464958 0.759259259259259 11.5 11 5 neurodegeneration 0.000216427322551855 0.0017338581798639 0.711147266464958 0.759259259259259 11.5 11 5 abnormal neuronal precursor proliferation 0.000216427322551855 0.0017338581798639 0.711147266464958 0.759259259259259 11.5 11 5 no abnormal phenotype detected 7.38594636378075e-101 1.22483610532697e-97 0.710977314914668 0.759077809798271 11.5 11 5 abnormal neuron differentiation 1.10966401659516e-07 2.03711383120329e-06 0.710837533334964 0.758928571428571 11.5 11 5 cochlear ganglion degeneration 0.000132166275312883 0.00110881487298751 0.710549161110488 0.758620689655172 11.5 11 5 lordosis 0.00668565313339842 0.0310851629333244 0.710549161110488 0.758620689655172 11.5 11 5 abnormal tail morphology 4.9547068366793e-05 0.000476782717842931 0.709570443257718 0.757575757575758 11.5 11 5 belly spot 0.00398730244548788 0.0204714444440683 0.709570443257718 0.757575757575758 11.5 11 5 abnormal middle ear ossicle morphology 0.00398730244548788 0.0204714444440683 0.709570443257718 0.757575757575758 11.5 11 5 male infertility 3.81975733655045e-29 8.6378603406084e-27 0.709457589111674 0.757455268389662 11.5 11 5 abnormal long bone metaphysis morphology 0.00239168708953753 0.0133993730523077 0.708803340075818 0.756756756756757 11.5 11 5 abnormal pancreatic beta cell physiology 0.00239168708953753 0.0133993730523077 0.708803340075818 0.756756756756757 11.5 11 5 abnormal testis morphology 1.01718847252204e-07 1.88123146869783e-06 0.708583214814925 0.756521739130435 11.5 11 5 increased circulating insulin level 3.62258395762376e-10 1.04175463521261e-08 0.708328694982017 0.75625 11.5 11 5 decreased insulin secretion 2.68922774305693e-06 3.53939365653657e-05 0.707678255409031 0.755555555555556 11.5 11 5 albuminuria 0.000871778532543936 0.0056252894933931 0.707678255409031 0.755555555555556 11.5 11 5 organ of Corti degeneration 0.000528999239209016 0.00369630788632704 0.70725347854504 0.755102040816326 11.5 11 5 increased sarcoma incidence 0.000528999239209016 0.00369630788632704 0.70725347854504 0.755102040816326 11.5 11 5 abnormal pancreatic islet morphology 0.000321861780883551 0.00245969640536968 0.706892818943538 0.754716981132076 11.5 11 5 increased osteoclast cell number 0.000119939626375026 0.00103266076194178 0.706313398600142 0.754098360655738 11.5 11 5 thymus hypoplasia 8.5137159941155e-09 1.90791608426687e-07 0.705868336597243 0.753623188405797 11.5 11 5 abnormal seminiferous tubule morphology 3.27926321246115e-09 7.65931196337756e-08 0.705682386034388 0.753424657534247 11.5 11 5 abnormal skeleton development 1.04494280031554e-05 0.000119783189667508 0.705365581371747 0.753086419753086 11.5 11 5 hyperglycemia 5.8326970589698e-06 7.02606970178566e-05 0.702474738825141 0.75 11.5 11 5 increased liver weight 5.8326970589698e-06 7.02606970178566e-05 0.702474738825141 0.75 11.5 11 5 abnormal long bone epiphyseal plate morphology 0.000177059374186397 0.0014511867983152 0.702474738825141 0.75 11.5 11 5 abnormal seminal vesicle morphology 0.000290023490200062 0.00225447947460204 0.702474738825141 0.75 11.5 11 5 abnormal myelopoiesis 0.00129279115659843 0.00790831854405944 0.702474738825141 0.75 11.5 11 5 head bobbing 0.00214074760095067 0.0120614035274401 0.702474738825141 0.75 11.5 11 5 abnormal pancreatic beta cell morphology 0.00214074760095067 0.0120614035274401 0.702474738825141 0.75 11.5 11 5 abnormal stria vascularis morphology 0.0100030606542115 0.0419252120932622 0.702474738825141 0.75 11.5 11 5 reddish skin 0.0100030606542115 0.0419252120932622 0.702474738825141 0.75 11.5 11 5 abnormal hormone level 0.0100030606542115 0.0419252120932622 0.702474738825141 0.75 11.5 11 5 abnormal mitotic spindle morphology 0.0100030606542115 0.0419252120932622 0.702474738825141 0.75 11.5 11 5 decreased body height 0.0169590773662509 0.0654549339775782 0.702474738825141 0.75 11.5 11 5 decreased fatty acid level 0.0169590773662509 0.0654549339775782 0.702474738825141 0.75 11.5 11 5 increased circulating total protein level 0.0169590773662509 0.0654549339775782 0.702474738825141 0.75 11.5 11 5 abnormal hair texture 0.0290664273401363 0.0997279144946056 0.702474738825141 0.75 11.5 11 5 abnormal response to tactile stimuli 0.0290664273401363 0.0997279144946056 0.702474738825141 0.75 11.5 11 5 abnormal rectum morphology 0.0901087948108031 0.230839986706357 0.702474738825141 0.75 11.5 11 5 mesocardia 0.0901087948108031 0.230839986706357 0.702474738825141 0.75 11.5 11 5 impaired embryo implantation 0.0901087948108031 0.230839986706357 0.702474738825141 0.75 11.5 11 5 interstitial pneumonia 0.0901087948108031 0.230839986706357 0.702474738825141 0.75 11.5 11 5 increased papilloma incidence 0.0901087948108031 0.230839986706357 0.702474738825141 0.75 11.5 11 5 altered tumor susceptibility 0.0901087948108031 0.230839986706357 0.702474738825141 0.75 11.5 11 5 abnormal corticospinal tract morphology 0.0901087948108031 0.230839986706357 0.702474738825141 0.75 11.5 11 5 increased urine phosphate level 0.0901087948108031 0.230839986706357 0.702474738825141 0.75 11.5 11 5 abnormal aorta elastic fiber morphology 0.0901087948108031 0.230839986706357 0.702474738825141 0.75 11.5 11 5 absent tail 0.0901087948108031 0.230839986706357 0.702474738825141 0.75 11.5 11 5 decreased circulating ketone body level 0.0901087948108031 0.230839986706357 0.702474738825141 0.75 11.5 11 5 decreased left ventricle systolic pressure 0.0901087948108031 0.230839986706357 0.702474738825141 0.75 11.5 11 5 increased hepatocyte proliferation 0.0901087948108031 0.230839986706357 0.702474738825141 0.75 11.5 11 5 bowed ulna 0.0901087948108031 0.230839986706357 0.702474738825141 0.75 11.5 11 5 absent cochlear hair cells 0.0901087948108031 0.230839986706357 0.702474738825141 0.75 11.5 11 5 small parietal bone 0.0901087948108031 0.230839986706357 0.702474738825141 0.75 11.5 11 5 abnormal somatic nervous system physiology 0.0901087948108031 0.230839986706357 0.702474738825141 0.75 11.5 11 5 abnormal thymus corticomedullary boundary morphology 0.0901087948108031 0.230839986706357 0.702474738825141 0.75 11.5 11 5 decreased keratinocyte proliferation 0.0901087948108031 0.230839986706357 0.702474738825141 0.75 11.5 11 5 hydrometra 0.0901087948108031 0.230839986706357 0.702474738825141 0.75 11.5 11 5 abnormal aorta elastic tissue morphology 0.0901087948108031 0.230839986706357 0.702474738825141 0.75 11.5 11 5 prenatal growth retardation 0.0901087948108031 0.230839986706357 0.702474738825141 0.75 11.5 11 5 abnormal brain wave pattern 0.000476068386196658 0.00342800286058762 0.702474738825141 0.75 11.5 11 5 abnormal female meiosis 0.000476068386196658 0.00342800286058762 0.702474738825141 0.75 11.5 11 5 vasculature congestion 0.0505860084903345 0.151880140156556 0.702474738825141 0.75 11.5 11 5 delayed hair appearance 0.0505860084903345 0.151880140156556 0.702474738825141 0.75 11.5 11 5 disorganized retinal layers 0.0505860084903345 0.151880140156556 0.702474738825141 0.75 11.5 11 5 abnormal extraembryonic endoderm formation 0.0505860084903345 0.151880140156556 0.702474738825141 0.75 11.5 11 5 paternal imprinting 0.0505860084903345 0.151880140156556 0.702474738825141 0.75 11.5 11 5 large intestinal inflammation 0.0505860084903345 0.151880140156556 0.702474738825141 0.75 11.5 11 5 bowed tibia 0.0505860084903345 0.151880140156556 0.702474738825141 0.75 11.5 11 5 bowed radius 0.0505860084903345 0.151880140156556 0.702474738825141 0.75 11.5 11 5 impaired somite development 0.0505860084903345 0.151880140156556 0.702474738825141 0.75 11.5 11 5 decreased skeletal muscle weight 0.0505860084903345 0.151880140156556 0.702474738825141 0.75 11.5 11 5 abnormal urinary bladder physiology 0.0505860084903345 0.151880140156556 0.702474738825141 0.75 11.5 11 5 decreased midbrain size 0.0505860084903345 0.151880140156556 0.702474738825141 0.75 11.5 11 5 decreased fibroblast apoptosis 0.0505860084903345 0.151880140156556 0.702474738825141 0.75 11.5 11 5 decreased adipocyte glucose uptake 0.0505860084903345 0.151880140156556 0.702474738825141 0.75 11.5 11 5 abnormal exoccipital bone morphology 0.167035001584539 0.34452700368287 0.702474738825141 0.75 11.5 11 5 abnormal esophageal epithelium morphology 0.167035001584539 0.34452700368287 0.702474738825141 0.75 11.5 11 5 enlarged pituitary gland 0.167035001584539 0.34452700368287 0.702474738825141 0.75 11.5 11 5 abnormal hypoglossal nerve morphology 0.167035001584539 0.34452700368287 0.702474738825141 0.75 11.5 11 5 abnormal vagus ganglion morphology 0.167035001584539 0.34452700368287 0.702474738825141 0.75 11.5 11 5 unidirectional circling 0.167035001584539 0.34452700368287 0.702474738825141 0.75 11.5 11 5 abnormal erythrocyte cell number 0.167035001584539 0.34452700368287 0.702474738825141 0.75 11.5 11 5 abnormal atrial thrombosis 0.167035001584539 0.34452700368287 0.702474738825141 0.75 11.5 11 5 abnormal secondary sex determination 0.167035001584539 0.34452700368287 0.702474738825141 0.75 11.5 11 5 coarse hair 0.167035001584539 0.34452700368287 0.702474738825141 0.75 11.5 11 5 abnormal thyroid physiology 0.167035001584539 0.34452700368287 0.702474738825141 0.75 11.5 11 5 head spot 0.167035001584539 0.34452700368287 0.702474738825141 0.75 11.5 11 5 vascular smooth muscle hypertrophy 0.167035001584539 0.34452700368287 0.702474738825141 0.75 11.5 11 5 decreased aerobic running capacity 0.167035001584539 0.34452700368287 0.702474738825141 0.75 11.5 11 5 altered response to CNS ischemic injury 0.167035001584539 0.34452700368287 0.702474738825141 0.75 11.5 11 5 absent tympanic ring 0.167035001584539 0.34452700368287 0.702474738825141 0.75 11.5 11 5 abnormal soft palate morphology 0.167035001584539 0.34452700368287 0.702474738825141 0.75 11.5 11 5 abnormal cellular cholesterol metabolism 0.167035001584539 0.34452700368287 0.702474738825141 0.75 11.5 11 5 abnormal neuron apoptosis 0.167035001584539 0.34452700368287 0.702474738825141 0.75 11.5 11 5 decreased susceptibility to age related obesity 0.167035001584539 0.34452700368287 0.702474738825141 0.75 11.5 11 5 abnormal umbilical artery morphology 0.167035001584539 0.34452700368287 0.702474738825141 0.75 11.5 11 5 loss of GABAergic neurons 0.167035001584539 0.34452700368287 0.702474738825141 0.75 11.5 11 5 decreased circulating renin level 0.167035001584539 0.34452700368287 0.702474738825141 0.75 11.5 11 5 abnormal platelet shape 0.167035001584539 0.34452700368287 0.702474738825141 0.75 11.5 11 5 pulmonary interstitial fibrosis 0.167035001584539 0.34452700368287 0.702474738825141 0.75 11.5 11 5 abnormal forelimb zeugopod morphology 0.167035001584539 0.34452700368287 0.702474738825141 0.75 11.5 11 5 lymph node inflammation 0.167035001584539 0.34452700368287 0.702474738825141 0.75 11.5 11 5 abnormal miscarriage rate 0.167035001584539 0.34452700368287 0.702474738825141 0.75 11.5 11 5 abnormal extraembryonic tissue physiology 0.167035001584539 0.34452700368287 0.702474738825141 0.75 11.5 11 5 abnormal lateral ganglionic eminence morphology 0.167035001584539 0.34452700368287 0.702474738825141 0.75 11.5 11 5 long femur 0.167035001584539 0.34452700368287 0.702474738825141 0.75 11.5 11 5 thin stria vascularis 0.167035001584539 0.34452700368287 0.702474738825141 0.75 11.5 11 5 small frontal bone 0.167035001584539 0.34452700368287 0.702474738825141 0.75 11.5 11 5 absent cochlear microphonics 0.167035001584539 0.34452700368287 0.702474738825141 0.75 11.5 11 5 non-pigmented tail tip 0.167035001584539 0.34452700368287 0.702474738825141 0.75 11.5 11 5 abnormal somite size 0.167035001584539 0.34452700368287 0.702474738825141 0.75 11.5 11 5 ectrodactyly 0.167035001584539 0.34452700368287 0.702474738825141 0.75 11.5 11 5 abnormal ilium morphology 0.167035001584539 0.34452700368287 0.702474738825141 0.75 11.5 11 5 abnormal mast cell differentiation 0.167035001584539 0.34452700368287 0.702474738825141 0.75 11.5 11 5 absent outer ear 0.167035001584539 0.34452700368287 0.702474738825141 0.75 11.5 11 5 abnormal corneocyte envelope morphology 0.167035001584539 0.34452700368287 0.702474738825141 0.75 11.5 11 5 abnormal epidermal lamellar body morphology 0.167035001584539 0.34452700368287 0.702474738825141 0.75 11.5 11 5 impaired behavioral response to alcohol 0.167035001584539 0.34452700368287 0.702474738825141 0.75 11.5 11 5 abnormal base-excision repair 0.167035001584539 0.34452700368287 0.702474738825141 0.75 11.5 11 5 abnormal lateral plate mesoderm morphology 0.167035001584539 0.34452700368287 0.702474738825141 0.75 11.5 11 5 myocardial trabeculae hypoplasia 0.167035001584539 0.34452700368287 0.702474738825141 0.75 11.5 11 5 sinoatrial block 0.167035001584539 0.34452700368287 0.702474738825141 0.75 11.5 11 5 increased heart right ventricle size 0.167035001584539 0.34452700368287 0.702474738825141 0.75 11.5 11 5 abnormal heart right ventricle pressure 0.167035001584539 0.34452700368287 0.702474738825141 0.75 11.5 11 5 abnormal stomach position or orientation 0.167035001584539 0.34452700368287 0.702474738825141 0.75 11.5 11 5 decreased lung compliance 0.167035001584539 0.34452700368287 0.702474738825141 0.75 11.5 11 5 increased airway resistance 0.167035001584539 0.34452700368287 0.702474738825141 0.75 11.5 11 5 abnormal bronchus epithelium morphology 0.167035001584539 0.34452700368287 0.702474738825141 0.75 11.5 11 5 absent ureteric bud 0.167035001584539 0.34452700368287 0.702474738825141 0.75 11.5 11 5 abnormal branching involved in ureteric bud morphogenesis 0.167035001584539 0.34452700368287 0.702474738825141 0.75 11.5 11 5 abnormal kidney mesenchyme morphology 0.167035001584539 0.34452700368287 0.702474738825141 0.75 11.5 11 5 impaired neuron differentiation 0.167035001584539 0.34452700368287 0.702474738825141 0.75 11.5 11 5 increased cardiac stroke volume 0.167035001584539 0.34452700368287 0.702474738825141 0.75 11.5 11 5 increased cornea thickness 0.167035001584539 0.34452700368287 0.702474738825141 0.75 11.5 11 5 retropleural edema 0.167035001584539 0.34452700368287 0.702474738825141 0.75 11.5 11 5 embryo cyst 0.167035001584539 0.34452700368287 0.702474738825141 0.75 11.5 11 5 increased brain apoptosis 0.167035001584539 0.34452700368287 0.702474738825141 0.75 11.5 11 5 decreased vascular endothelial cell proliferation 0.167035001584539 0.34452700368287 0.702474738825141 0.75 11.5 11 5 weight loss 2.28480779332918e-10 6.72598743894242e-09 0.70113669170357 0.748571428571429 11.5 11 5 deafness 2.00728653985344e-06 2.69898663128942e-05 0.700109504014282 0.747474747474748 11.5 11 5 abnormal locomotor activation 5.26853688622287e-06 6.39291975828263e-05 0.699901571283657 0.747252747252747 11.5 11 5 abnormal response to infection 2.25396925387932e-05 0.000239093753476538 0.69951071039128 0.746835443037975 11.5 11 5 abnormal response to novel object 0.000700192455157942 0.00472653658671745 0.697883400662885 0.745098039215686 11.5 11 5 increased kidney weight 0.000700192455157942 0.00472653658671745 0.697883400662885 0.745098039215686 11.5 11 5 increased leukocyte cell number 1.36004137707228e-08 2.96763414514676e-07 0.697630085453933 0.744827586206897 11.5 11 5 increased systemic arterial blood pressure 0.00115308249815673 0.00722491867547826 0.697492648478864 0.74468085106383 11.5 11 5 abnormal male reproductive system morphology 0.00190462591651978 0.0109290818162467 0.697029198214094 0.744186046511628 11.5 11 5 abnormal vasculogenesis 0.00190462591651978 0.0109290818162467 0.697029198214094 0.744186046511628 11.5 11 5 abnormal axon guidance 0.00190462591651978 0.0109290818162467 0.697029198214094 0.744186046511628 11.5 11 5 delayed endochondral bone ossification 0.00190462591651978 0.0109290818162467 0.697029198214094 0.744186046511628 11.5 11 5 acanthosis 0.0031572680355476 0.0167635095804155 0.696470681228345 0.743589743589744 11.5 11 5 abnormal response to injury 0.0031572680355476 0.0167635095804155 0.696470681228345 0.743589743589744 11.5 11 5 decreased trabecular bone volume 0.0031572680355476 0.0167635095804155 0.696470681228345 0.743589743589744 11.5 11 5 small seminiferous tubules 5.35391621693904e-05 0.000512225638062918 0.696146137574464 0.743243243243243 11.5 11 5 spleen hypoplasia 1.62782899808924e-06 2.2621366663391e-05 0.695784503217283 0.742857142857143 11.5 11 5 abnormal lens morphology 1.33279091950853e-07 2.39930464218586e-06 0.695157293629046 0.7421875 11.5 11 5 increased lung adenoma incidence 0.0087975927900695 0.0390437324983013 0.694921247009817 0.741935483870968 11.5 11 5 decreased neuronal precursor cell number 0.0087975927900695 0.0390437324983013 0.694921247009817 0.741935483870968 11.5 11 5 small cranium 0.0087975927900695 0.0390437324983013 0.694921247009817 0.741935483870968 11.5 11 5 abnormal intestine physiology 0.0087975927900695 0.0390437324983013 0.694921247009817 0.741935483870968 11.5 11 5 abnormal bone trabecula morphology 0.0148230374498971 0.058699950320248 0.693802211185325 0.740740740740741 11.5 11 5 increased body length 0.00102379665754181 0.00651413089131651 0.693108408974139 0.74 11.5 11 5 abnormal digestive system physiology 0.00102379665754181 0.00651413089131651 0.693108408974139 0.74 11.5 11 5 abnormal coat appearance 0.000126792728767018 0.0010655301108377 0.692293945508835 0.739130434782609 11.5 11 5 blistering 0.0251919066601568 0.0870950212885894 0.692293945508835 0.739130434782609 11.5 11 5 abnormal circulating insulin level 0.0251919066601568 0.0870950212885894 0.692293945508835 0.739130434782609 11.5 11 5 abnormal cardiovascular development 0.0251919066601568 0.0870950212885894 0.692293945508835 0.739130434782609 11.5 11 5 abnormal vertebral artery topology 0.0251919066601568 0.0870950212885894 0.692293945508835 0.739130434782609 11.5 11 5 abnormal reproductive system morphology 0.00278685509125977 0.0151030545523065 0.691324346145377 0.738095238095238 11.5 11 5 abnormal spleen white pulp morphology 0.00278685509125977 0.0151030545523065 0.691324346145377 0.738095238095238 11.5 11 5 decreased B cell number 5.59773806234951e-11 1.83215439869663e-09 0.691107833666158 0.737864077669903 11.5 11 5 increased circulating glucose level 5.9672982488106e-08 1.1551482018612e-06 0.690849861350494 0.737588652482269 11.5 11 5 abnormal CNS synaptic transmission 5.51881653021469e-06 6.68031927927447e-05 0.690648564770846 0.737373737373737 11.5 11 5 increased grooming behavior 0.00462177693984521 0.0231088846992261 0.690150620600139 0.736842105263158 11.5 11 5 abnormal reproductive system physiology 0.00462177693984521 0.0231088846992261 0.690150620600139 0.736842105263158 11.5 11 5 abnormal compact bone morphology 0.00462177693984521 0.0231088846992261 0.690150620600139 0.736842105263158 11.5 11 5 irregular coat pigmentation 0.0433144385659923 0.132202044089455 0.690150620600139 0.736842105263158 11.5 11 5 enlarged adrenal glands 0.0433144385659923 0.132202044089455 0.690150620600139 0.736842105263158 11.5 11 5 thin dermal layer 0.0433144385659923 0.132202044089455 0.690150620600139 0.736842105263158 11.5 11 5 decreased tumor incidence 0.0433144385659923 0.132202044089455 0.690150620600139 0.736842105263158 11.5 11 5 increased susceptibility to ischemic brain injury 0.0433144385659923 0.132202044089455 0.690150620600139 0.736842105263158 11.5 11 5 abnormal cochlear inner hair cell morphology 0.0433144385659923 0.132202044089455 0.690150620600139 0.736842105263158 11.5 11 5 increased circulating VLDL cholesterol level 0.0433144385659923 0.132202044089455 0.690150620600139 0.736842105263158 11.5 11 5 decreased circulating magnesium level 0.0433144385659923 0.132202044089455 0.690150620600139 0.736842105263158 11.5 11 5 increased macrophage cell number 0.000552496188172431 0.00385507508577538 0.690150620600139 0.736842105263158 11.5 11 5 abnormal retinal photoreceptor morphology 0.00769857525189261 0.0354305382776741 0.688700724338374 0.735294117647059 11.5 11 5 lung hemorrhage 0.00769857525189261 0.0354305382776741 0.688700724338374 0.735294117647059 11.5 11 5 impaired synaptic plasticity 0.00769857525189261 0.0354305382776741 0.688700724338374 0.735294117647059 11.5 11 5 abnormal vision 0.00769857525189261 0.0354305382776741 0.688700724338374 0.735294117647059 11.5 11 5 abnormal epidermis stratum corneum morphology 0.00148782668306367 0.0088013528516549 0.688138519665444 0.73469387755102 11.5 11 5 spleen hyperplasia 9.99492303986938e-05 0.000894329894304859 0.686864189073472 0.733333333333333 11.5 11 5 gastrointestinal hemorrhage 0.0128930565024065 0.0531865307624149 0.686864189073471 0.733333333333333 11.5 11 5 increased metastatic potential 0.0128930565024065 0.0531865307624149 0.686864189073471 0.733333333333333 11.5 11 5 enhanced paired-pulse facilitation 0.0128930565024065 0.0531865307624149 0.686864189073471 0.733333333333333 11.5 11 5 abnormal synaptic transmission 0.0128930565024065 0.0531865307624149 0.686864189073471 0.733333333333333 11.5 11 5 abnormal epidermis stratum spinosum morphology 0.0757124260418928 0.197726676933552 0.686864189073471 0.733333333333333 11.5 11 5 absent egg cylinders 0.0757124260418928 0.197726676933552 0.686864189073471 0.733333333333333 11.5 11 5 abnormal respiratory system morphology 0.0757124260418928 0.197726676933552 0.686864189073471 0.733333333333333 11.5 11 5 abnormal bronchus morphology 0.0757124260418928 0.197726676933552 0.686864189073471 0.733333333333333 11.5 11 5 altered righting response 0.0757124260418928 0.197726676933552 0.686864189073471 0.733333333333333 11.5 11 5 abnormal Muller cell morphology 0.0757124260418928 0.197726676933552 0.686864189073471 0.733333333333333 11.5 11 5 liver vascular congestion 0.0757124260418928 0.197726676933552 0.686864189073471 0.733333333333333 11.5 11 5 abnormal microglial cell activation 0.0757124260418928 0.197726676933552 0.686864189073471 0.733333333333333 11.5 11 5 decreased trabecular bone mass 0.0757124260418928 0.197726676933552 0.686864189073471 0.733333333333333 11.5 11 5 decreased liver weight 0.000162454819084189 0.00134477990839241 0.685984721481828 0.732394366197183 11.5 11 5 increased body weight 2.85619525880764e-11 9.79970442246071e-10 0.685749149805495 0.732142857142857 11.5 11 5 increased tumor growth/size 0.00404853023477417 0.0207643689876304 0.685341208609894 0.731707317073171 11.5 11 5 decreased compact bone thickness 0.000264341417600633 0.00207428793779677 0.685000242834466 0.73134328358209 11.5 11 5 abnormal stomach morphology 0.021739500006183 0.0794082324014393 0.684462566034753 0.730769230769231 11.5 11 5 abnormal ureter morphology 0.021739500006183 0.0794082324014393 0.684462566034753 0.730769230769231 11.5 11 5 abnormal Schwann cell morphology 0.021739500006183 0.0794082324014393 0.684462566034753 0.730769230769231 11.5 11 5 increased brown adipose tissue amount 0.00671250211282948 0.031151770532954 0.68348893507311 0.72972972972973 11.5 11 5 skin inflammation 0.00671250211282948 0.031151770532954 0.68348893507311 0.72972972972973 11.5 11 5 abnormal cardiovascular system morphology 0.00214842991125163 0.0120909941272363 0.682961551635554 0.729166666666667 11.5 11 5 impaired fertilization 0.00023306328849921 0.00184926612485418 0.682404032001566 0.728571428571429 11.5 11 5 abnormal circadian rhythm 0.00353618527631003 0.0181928870213469 0.68118762552741 0.727272727272727 11.5 11 5 embryonic lethality, incomplete penetrance 0.00353618527631003 0.0181928870213469 0.68118762552741 0.727272727272727 11.5 11 5 abnormal skeleton physiology 0.0111775354919557 0.0466512072755701 0.68118762552741 0.727272727272727 11.5 11 5 dilated heart atrium 0.0111775354919557 0.0466512072755701 0.68118762552741 0.727272727272727 11.5 11 5 cardiovascular system phenotype 0.0111775354919557 0.0466512072755701 0.68118762552741 0.727272727272727 11.5 11 5 testis hypoplasia 0.0369793560237358 0.119851658773997 0.68118762552741 0.727272727272727 11.5 11 5 increased coping response 0.0369793560237358 0.119851658773997 0.68118762552741 0.727272727272727 11.5 11 5 abnormal sperm midpiece morphology 0.0369793560237358 0.119851658773997 0.68118762552741 0.727272727272727 11.5 11 5 abnormal ear position 0.135731994532569 0.294192881845367 0.68118762552741 0.727272727272727 11.5 11 5 enlarged cranium 0.135731994532569 0.294192881845367 0.68118762552741 0.727272727272727 11.5 11 5 abnormal large intestine morphology 0.135731994532569 0.294192881845367 0.68118762552741 0.727272727272727 11.5 11 5 abnormal sebaceous gland morphology 0.135731994532569 0.294192881845367 0.68118762552741 0.727272727272727 11.5 11 5 social withdrawal 0.135731994532569 0.294192881845367 0.68118762552741 0.727272727272727 11.5 11 5 abnormal hemoglobin 0.135731994532569 0.294192881845367 0.68118762552741 0.727272727272727 11.5 11 5 secondary sex reversal 0.135731994532569 0.294192881845367 0.68118762552741 0.727272727272727 11.5 11 5 abnormal primary sex determination 0.135731994532569 0.294192881845367 0.68118762552741 0.727272727272727 11.5 11 5 abnormal larynx morphology 0.135731994532569 0.294192881845367 0.68118762552741 0.727272727272727 11.5 11 5 abnormal vestibular ganglion morphology 0.135731994532569 0.294192881845367 0.68118762552741 0.727272727272727 11.5 11 5 allodynia 0.135731994532569 0.294192881845367 0.68118762552741 0.727272727272727 11.5 11 5 impaired luteinization 0.135731994532569 0.294192881845367 0.68118762552741 0.727272727272727 11.5 11 5 dilated renal glomerular capsule 0.135731994532569 0.294192881845367 0.68118762552741 0.727272727272727 11.5 11 5 abnormal pituitary gland development 0.135731994532569 0.294192881845367 0.68118762552741 0.727272727272727 11.5 11 5 cyclopia 0.135731994532569 0.294192881845367 0.68118762552741 0.727272727272727 11.5 11 5 abnormal dorsal-ventral polarity of the somites 0.135731994532569 0.294192881845367 0.68118762552741 0.727272727272727 11.5 11 5 abnormal aorta smooth muscle morphology 0.135731994532569 0.294192881845367 0.68118762552741 0.727272727272727 11.5 11 5 decreased core body temperature 0.135731994532569 0.294192881845367 0.68118762552741 0.727272727272727 11.5 11 5 increased pancreatic beta cell proliferation 0.135731994532569 0.294192881845367 0.68118762552741 0.727272727272727 11.5 11 5 hypolactation 0.135731994532569 0.294192881845367 0.68118762552741 0.727272727272727 11.5 11 5 thin hypoglossal nerve 0.135731994532569 0.294192881845367 0.68118762552741 0.727272727272727 11.5 11 5 increased anxiety-related response 3.17794576484685e-07 5.41447951373735e-06 0.680575046727475 0.726618705035971 11.5 11 5 abnormal nervous system electrophysiology 6.88526305320407e-05 0.000642667611438841 0.680173953465613 0.726190476190476 11.5 11 5 increased eosinophil cell number 0.000616731499085778 0.00424376100684889 0.679814263379169 0.725806451612903 11.5 11 5 abnormal cued conditioning behavior 0.00187903633527058 0.0109080580723117 0.679518048013862 0.725490196078431 11.5 11 5 abnormal female reproductive system morphology 0.00583718554493945 0.0272932312839039 0.679058914197637 0.725 11.5 11 5 abnormal retinal pigmentation 6.0609900835416e-05 0.000576463319740403 0.678251471969102 0.724137931034483 11.5 11 5 abnormal spermiogenesis 0.00100507500847371 0.00644361877210918 0.678251471969102 0.724137931034483 11.5 11 5 focal hair loss 0.0187112553963459 0.0705541866380149 0.678251471969102 0.724137931034483 11.5 11 5 stomach inflammation 0.0187112553963459 0.0705541866380149 0.678251471969102 0.724137931034483 11.5 11 5 decreased bone strength 0.0187112553963459 0.0705541866380149 0.678251471969102 0.724137931034483 11.5 11 5 decreased bone trabecula number 0.00308177804888694 0.0165023232833977 0.677564287093753 0.723404255319149 11.5 11 5 head tilt 0.00966831862741812 0.0411362989343654 0.676457155905692 0.722222222222222 11.5 11 5 abnormal stomach glandular epithelium morphology 0.063649951316693 0.186819178643391 0.676457155905692 0.722222222222222 11.5 11 5 abnormal iron level 0.063649951316693 0.186819178643391 0.676457155905692 0.722222222222222 11.5 11 5 abnormal thymus medulla morphology 0.063649951316693 0.186819178643391 0.676457155905692 0.722222222222222 11.5 11 5 abnormal Peyer's patch follicle morphology 0.063649951316693 0.186819178643391 0.676457155905692 0.722222222222222 11.5 11 5 abnormal white adipose tissue morphology 0.063649951316693 0.186819178643391 0.676457155905692 0.722222222222222 11.5 11 5 increased circulating glycerol level 0.063649951316693 0.186819178643391 0.676457155905692 0.722222222222222 11.5 11 5 abnormal neutrophil morphology 0.063649951316693 0.186819178643391 0.676457155905692 0.722222222222222 11.5 11 5 decreased pulmonary respiratory rate 0.063649951316693 0.186819178643391 0.676457155905692 0.722222222222222 11.5 11 5 abnormal macrophage chemotaxis 0.063649951316693 0.186819178643391 0.676457155905692 0.722222222222222 11.5 11 5 abnormal organ of Corti morphology 0.00506594712600471 0.0246123896014389 0.675247035769903 0.720930232558139 11.5 11 5 decreased oxygen consumption 0.00506594712600471 0.0246123896014389 0.675247035769903 0.720930232558139 11.5 11 5 abnormal vertebrae development 0.0315304566475002 0.108033072879692 0.674375749272136 0.72 11.5 11 5 abnormal dendritic cell physiology 1.39620856197461e-05 0.000155047714192493 0.674025606100136 0.719626168224299 11.5 11 5 abnormal response/metabolism to endogenous compounds 0.000138513699020884 0.00116011052631128 0.673918855133062 0.719512195121951 11.5 11 5 increased dopamine level 0.0160791824564621 0.0624397890535613 0.67320495804076 0.71875 11.5 11 5 abnormal lumbar vertebrae morphology 0.0160791824564621 0.0624397890535613 0.67320495804076 0.71875 11.5 11 5 decreased neutrophil cell number 6.71334661183432e-06 8.02858158506628e-05 0.672454450841161 0.717948717948718 11.5 11 5 increased autoantibody level 0.00834961778714821 0.0374903867247855 0.672454450841161 0.717948717948718 11.5 11 5 abnormal sleep pattern 0.00439002240749177 0.0221377758041095 0.671932358876222 0.717391304347826 11.5 11 5 abnormal placenta development 0.002329171933736 0.0130785895827727 0.671548177996361 0.716981132075472 11.5 11 5 small superior cervical ganglion 0.026872979439111 0.0925852304082944 0.669023560785849 0.714285714285714 11.5 11 5 abnormal respiration 0.026872979439111 0.0925852304082944 0.669023560785849 0.714285714285714 11.5 11 5 abnormal renal tubule epithelium morphology 0.026872979439111 0.0925852304082944 0.669023560785849 0.714285714285714 11.5 11 5 decreased cochlear outer hair cell number 0.0535849640404429 0.159919133833955 0.669023560785849 0.714285714285714 11.5 11 5 abnormal clavicle morphology 0.0535849640404429 0.159919133833955 0.669023560785849 0.714285714285714 11.5 11 5 increased aggression towards males 0.111401497538299 0.27697273875714 0.669023560785849 0.714285714285714 11.5 11 5 abnormal pinna reflex 0.111401497538299 0.27697273875714 0.669023560785849 0.714285714285714 11.5 11 5 absent visceral yolk sac blood islands 0.111401497538299 0.27697273875714 0.669023560785849 0.714285714285714 11.5 11 5 abnormal adrenal gland secretion 0.111401497538299 0.27697273875714 0.669023560785849 0.714285714285714 11.5 11 5 abnormal iris pigmentation 0.111401497538299 0.27697273875714 0.669023560785849 0.714285714285714 11.5 11 5 abnormal glucose tolerance 0.111401497538299 0.27697273875714 0.669023560785849 0.714285714285714 11.5 11 5 pulmonary alveolar hemorrhage 0.111401497538299 0.27697273875714 0.669023560785849 0.714285714285714 11.5 11 5 cochlear degeneration 0.254247787870313 0.447515668343032 0.669023560785849 0.714285714285714 11.5 11 5 growth retardation of molars 0.254247787870313 0.447515668343032 0.669023560785849 0.714285714285714 11.5 11 5 absent hair follicles 0.254247787870313 0.447515668343032 0.669023560785849 0.714285714285714 11.5 11 5 mottled coat 0.254247787870313 0.447515668343032 0.669023560785849 0.714285714285714 11.5 11 5 prostate gland epithelial hyperplasia 0.254247787870313 0.447515668343032 0.669023560785849 0.714285714285714 11.5 11 5 retina hyperplasia 0.254247787870313 0.447515668343032 0.669023560785849 0.714285714285714 11.5 11 5 limp posture 0.254247787870313 0.447515668343032 0.669023560785849 0.714285714285714 11.5 11 5 absent amniotic folds 0.254247787870313 0.447515668343032 0.669023560785849 0.714285714285714 11.5 11 5 decreased activated T cell number 0.254247787870313 0.447515668343032 0.669023560785849 0.714285714285714 11.5 11 5 increased colonic adenoma incidence 0.254247787870313 0.447515668343032 0.669023560785849 0.714285714285714 11.5 11 5 abnormal melanocyte morphology 0.254247787870313 0.447515668343032 0.669023560785849 0.714285714285714 11.5 11 5 absent tunnel of Corti 0.254247787870313 0.447515668343032 0.669023560785849 0.714285714285714 11.5 11 5 abnormal sinus venosus morphology 0.254247787870313 0.447515668343032 0.669023560785849 0.714285714285714 11.5 11 5 abnormal hard palate morphology 0.254247787870313 0.447515668343032 0.669023560785849 0.714285714285714 11.5 11 5 abnormal nephron morphology 0.254247787870313 0.447515668343032 0.669023560785849 0.714285714285714 11.5 11 5 abnormal organ of Corti supporting cell morphology 0.254247787870313 0.447515668343032 0.669023560785849 0.714285714285714 11.5 11 5 absent vestibular saccule 0.254247787870313 0.447515668343032 0.669023560785849 0.714285714285714 11.5 11 5 absent ulna 0.254247787870313 0.447515668343032 0.669023560785849 0.714285714285714 11.5 11 5 abnormal strial marginal cell morphology 0.254247787870313 0.447515668343032 0.669023560785849 0.714285714285714 11.5 11 5 abnormal negative T cell selection 0.254247787870313 0.447515668343032 0.669023560785849 0.714285714285714 11.5 11 5 increased prostate gland weight 0.254247787870313 0.447515668343032 0.669023560785849 0.714285714285714 11.5 11 5 increased thyroid-stimulating hormone level 0.254247787870313 0.447515668343032 0.669023560785849 0.714285714285714 11.5 11 5 atherosclerotic lesions 0.254247787870313 0.447515668343032 0.669023560785849 0.714285714285714 11.5 11 5 abnormal body temperature 0.254247787870313 0.447515668343032 0.669023560785849 0.714285714285714 11.5 11 5 retinal pigment epithelium atrophy 0.254247787870313 0.447515668343032 0.669023560785849 0.714285714285714 11.5 11 5 absent popliteal lymph nodes 0.254247787870313 0.447515668343032 0.669023560785849 0.714285714285714 11.5 11 5 abnormal spinal cord central canal morphology 0.254247787870313 0.447515668343032 0.669023560785849 0.714285714285714 11.5 11 5 abnormal sperm annulus morphology 0.254247787870313 0.447515668343032 0.669023560785849 0.714285714285714 11.5 11 5 increased DN3 thymocyte number 0.254247787870313 0.447515668343032 0.669023560785849 0.714285714285714 11.5 11 5 focal dorsal hair loss 0.254247787870313 0.447515668343032 0.669023560785849 0.714285714285714 11.5 11 5 decreased T-helper 17 cell number 0.254247787870313 0.447515668343032 0.669023560785849 0.714285714285714 11.5 11 5 long stride length 0.254247787870313 0.447515668343032 0.669023560785849 0.714285714285714 11.5 11 5 thick mitral valve cusps 0.254247787870313 0.447515668343032 0.669023560785849 0.714285714285714 11.5 11 5 absent heart tube 0.254247787870313 0.447515668343032 0.669023560785849 0.714285714285714 11.5 11 5 decreased volumetric bone mineral density 0.254247787870313 0.447515668343032 0.669023560785849 0.714285714285714 11.5 11 5 decreased areal bone mineral density 0.254247787870313 0.447515668343032 0.669023560785849 0.714285714285714 11.5 11 5 abnormal Mullerian duct topology 0.254247787870313 0.447515668343032 0.669023560785849 0.714285714285714 11.5 11 5 embryo tumor 0.254247787870313 0.447515668343032 0.669023560785849 0.714285714285714 11.5 11 5 abnormal tectorial membrane striated-sheet matrix morphology 0.254247787870313 0.447515668343032 0.669023560785849 0.714285714285714 11.5 11 5 lung inflammation 2.17510735640962e-06 2.91675447389161e-05 0.668039702608223 0.713235294117647 11.5 11 5 abnormal cartilage development 0.00620845457738509 0.0289475740604413 0.666050122737912 0.711111111111111 11.5 11 5 abnormal ovarian follicle morphology 0.00620845457738509 0.0289475740604413 0.666050122737912 0.711111111111111 11.5 11 5 decreased osteoclast cell number 0.00620845457738509 0.0289475740604413 0.666050122737912 0.711111111111111 11.5 11 5 decreased double-positive T cell number 6.14744797176479e-05 0.000581436381359883 0.665009419421134 0.71 11.5 11 5 autoimmune response 0.0229041900214525 0.083478641286979 0.664707279748521 0.709677419354839 11.5 11 5 abnormal CD8-positive, alpha beta T cell morphology 0.0229041900214525 0.083478641286979 0.664707279748521 0.709677419354839 11.5 11 5 increased B cell number 1.60233573646064e-05 0.000176363280727692 0.664449040712099 0.709401709401709 11.5 11 5 decreased food intake 0.000382568005107397 0.00286637925513449 0.663942369184944 0.708860759493671 11.5 11 5 abnormal hair shaft morphology 0.00534848066885835 0.0254628625144213 0.663448364445967 0.708333333333333 11.5 11 5 abnormal digestive system morphology 0.0451859206596424 0.137073143464464 0.663448364445967 0.708333333333333 11.5 11 5 abnormal cardiac muscle contractility 0.0451859206596424 0.137073143464464 0.663448364445967 0.708333333333333 11.5 11 5 decreased ovulation rate 0.0451859206596424 0.137073143464464 0.663448364445967 0.708333333333333 11.5 11 5 decreased T cell number 5.35228493474625e-07 8.45321192075003e-06 0.663205964605102 0.708074534161491 11.5 11 5 increased bone mineral density 2.55126338215013e-05 0.000269480580174031 0.663102998301018 0.707964601769911 11.5 11 5 dermatitis 0.00245330225029235 0.0136218512223264 0.662102627398409 0.706896551724138 11.5 11 5 abnormal trabecular bone morphology 1.9353956812728e-05 0.000208675297633092 0.661152695364839 0.705882352941177 11.5 11 5 abnormal oocyte morphology 0.0195270400681072 0.072121027719995 0.661152695364839 0.705882352941177 11.5 11 5 abnormal bone remodeling 0.0195270400681072 0.072121027719995 0.661152695364839 0.705882352941177 11.5 11 5 increased width of hypertrophic chondrocyte zone 0.0195270400681072 0.072121027719995 0.661152695364839 0.705882352941177 11.5 11 5 abnormal skin physiology 0.0195270400681072 0.072121027719995 0.661152695364839 0.705882352941177 11.5 11 5 distended urinary bladder 0.0920972096848684 0.235086515229461 0.661152695364839 0.705882352941177 11.5 11 5 abnormal heart rate 0.0920972096848684 0.235086515229461 0.661152695364839 0.705882352941177 11.5 11 5 abnormal touch/ nociception 0.0920972096848684 0.235086515229461 0.661152695364839 0.705882352941177 11.5 11 5 increased regulatory T cell number 0.0920972096848684 0.235086515229461 0.661152695364839 0.705882352941177 11.5 11 5 decreased growth hormone level 0.0920972096848684 0.235086515229461 0.661152695364839 0.705882352941177 11.5 11 5 pancytopenia 0.0920972096848684 0.235086515229461 0.661152695364839 0.705882352941177 11.5 11 5 delayed heart development 0.0920972096848684 0.235086515229461 0.661152695364839 0.705882352941177 11.5 11 5 abnormal ovary morphology 0.000984221467258762 0.00632622971526142 0.659600693732527 0.704225352112676 11.5 11 5 cryptorchism 0.0381660985773621 0.122185547247346 0.659112100626059 0.703703703703704 11.5 11 5 decreased eosinophil cell number 0.00182847636328156 0.0106269508263151 0.65857006764857 0.703125 11.5 11 5 decreased circulating chloride level 0.0166547940255368 0.064480622783693 0.658174530070402 0.702702702702703 11.5 11 5 abnormal calcium ion homeostasis 0.0166547940255368 0.064480622783693 0.658174530070402 0.702702702702703 11.5 11 5 abnormal humerus morphology 0.0166547940255368 0.064480622783693 0.658174530070402 0.702702702702703 11.5 11 5 increased food intake 0.000399067513980596 0.00298550508579468 0.657873168106085 0.702380952380952 11.5 11 5 abnormal innervation 0.00747374125277461 0.0346199839223032 0.657635925708643 0.702127659574468 11.5 11 5 increased total body fat amount 9.64072205723898e-06 0.000111282116553977 0.657041049249386 0.701492537313433 11.5 11 5 abnormal femur morphology 0.00157794112844468 0.00931228601899442 0.657041049249386 0.701492537313433 11.5 11 5 maternal effect 0.00157794112844468 0.00931228601899442 0.657041049249386 0.701492537313433 11.5 11 5 increased sensitivity to xenobiotic induced morbidity/mortality 6.70380946154853e-05 0.000629272680588753 0.655643089570132 0.7 11.5 11 5 abnormal social investigation 0.000636132012546651 0.00437121099781711 0.655643089570132 0.7 11.5 11 5 increased susceptibility to weight loss 0.0142119596856353 0.0567907625992253 0.655643089570132 0.7 11.5 11 5 waved hair 0.0765597980929894 0.19941622801708 0.655643089570132 0.7 11.5 11 5 abnormal dopamine level 0.0765597980929894 0.19941622801708 0.655643089570132 0.7 11.5 11 5 abnormal fibula morphology 0.0765597980929894 0.19941622801708 0.655643089570132 0.7 11.5 11 5 absent placental labyrinth 0.0765597980929894 0.19941622801708 0.655643089570132 0.7 11.5 11 5 enhanced behavioral response to xenobiotic 0.0765597980929894 0.19941622801708 0.655643089570132 0.7 11.5 11 5 absent maxillary shelf 0.199995306807705 0.40644471052628 0.655643089570132 0.7 11.5 11 5 kidney hemorrhage 0.199995306807705 0.40644471052628 0.655643089570132 0.7 11.5 11 5 enlarged testis 0.199995306807705 0.40644471052628 0.655643089570132 0.7 11.5 11 5 abnormal optic nerve innervation 0.199995306807705 0.40644471052628 0.655643089570132 0.7 11.5 11 5 abnormal pituitary secretion 0.199995306807705 0.40644471052628 0.655643089570132 0.7 11.5 11 5 abnormal immune cell physiology 0.199995306807705 0.40644471052628 0.655643089570132 0.7 11.5 11 5 alcohol preference 0.199995306807705 0.40644471052628 0.655643089570132 0.7 11.5 11 5 abnormal airway responsiveness 0.199995306807705 0.40644471052628 0.655643089570132 0.7 11.5 11 5 abnormal neuron specification 0.199995306807705 0.40644471052628 0.655643089570132 0.7 11.5 11 5 primary sex reversal 0.199995306807705 0.40644471052628 0.655643089570132 0.7 11.5 11 5 rickets 0.199995306807705 0.40644471052628 0.655643089570132 0.7 11.5 11 5 lymphedema 0.199995306807705 0.40644471052628 0.655643089570132 0.7 11.5 11 5 abnormal gonadal fat pad morphology 0.199995306807705 0.40644471052628 0.655643089570132 0.7 11.5 11 5 decreased thyroxine level 0.199995306807705 0.40644471052628 0.655643089570132 0.7 11.5 11 5 abnormal spinal cord dorsal column morphology 0.199995306807705 0.40644471052628 0.655643089570132 0.7 11.5 11 5 umbilical hernia 0.199995306807705 0.40644471052628 0.655643089570132 0.7 11.5 11 5 sinus bradycardia 0.199995306807705 0.40644471052628 0.655643089570132 0.7 11.5 11 5 decreased trabecular bone connectivity density 0.199995306807705 0.40644471052628 0.655643089570132 0.7 11.5 11 5 abnormal circadian temperature homeostasis 0.199995306807705 0.40644471052628 0.655643089570132 0.7 11.5 11 5 increased susceptibility to pharmacologically induced seizures 0.000223978907793057 0.0017800240675247 0.653691770851173 0.697916666666667 11.5 11 5 abnormal ovarian folliculogenesis 0.027352970474827 0.0940435577831819 0.652804807797101 0.696969696969697 11.5 11 5 diarrhea 0.027352970474827 0.0940435577831819 0.652804807797101 0.696969696969697 11.5 11 5 increased neutrophil cell number 7.50123884954147e-06 8.84328513660398e-05 0.652413320655993 0.696551724137931 11.5 11 5 increased sensitivity to induced morbidity/mortality 5.44179852463165e-07 8.56738850001343e-06 0.651570772243609 0.695652173913043 11.5 11 5 abnormal blood vessel physiology 0.0639220974262024 0.186956163842067 0.651570772243609 0.695652173913043 11.5 11 5 abnormal carpal bone morphology 0.0639220974262024 0.186956163842067 0.651570772243609 0.695652173913043 11.5 11 5 hypotension 0.0639220974262024 0.186956163842067 0.651570772243609 0.695652173913043 11.5 11 5 failure of embryo implantation 0.0639220974262024 0.186956163842067 0.651570772243609 0.695652173913043 11.5 11 5 pancreas inflammation 0.0639220974262024 0.186956163842067 0.651570772243609 0.695652173913043 11.5 11 5 abnormal lens development 0.0639220974262024 0.186956163842067 0.651570772243609 0.695652173913043 11.5 11 5 abnormal uterus morphology 0.0232035163344523 0.0843224936186271 0.650439572986242 0.694444444444444 11.5 11 5 abnormal epidermis stratum granulosum morphology 0.0232035163344523 0.0843224936186271 0.650439572986242 0.694444444444444 11.5 11 5 short radius 0.0232035163344523 0.0843224936186271 0.650439572986242 0.694444444444444 11.5 11 5 teratozoospermia 0.000560900583707102 0.00390823585986391 0.649256955580812 0.693181818181818 11.5 11 5 small ovary 0.000483812292440352 0.00344837558007271 0.648438220453977 0.692307692307692 11.5 11 5 abnormal B cell differentiation 0.000483812292440352 0.00344837558007271 0.648438220453977 0.692307692307692 11.5 11 5 absent corpus luteum 0.00757493687922557 0.034991003690016 0.648438220453977 0.692307692307692 11.5 11 5 increased susceptibility to injury 0.00757493687922557 0.034991003690016 0.648438220453977 0.692307692307692 11.5 11 5 decreased body temperature 0.00757493687922557 0.034991003690016 0.648438220453977 0.692307692307692 11.5 11 5 impaired macrophage chemotaxis 0.0197072767482824 0.0727327164856861 0.648438220453977 0.692307692307692 11.5 11 5 abnormal leukocyte cell number 0.0535601090904638 0.159919133833955 0.648438220453977 0.692307692307692 11.5 11 5 abnormal kidney cortex morphology 0.0535601090904638 0.159919133833955 0.648438220453977 0.692307692307692 11.5 11 5 small seminal vesicle 0.0535601090904638 0.159919133833955 0.648438220453977 0.692307692307692 11.5 11 5 pulmonary edema 0.0535601090904638 0.159919133833955 0.648438220453977 0.692307692307692 11.5 11 5 short hair 0.160775514903549 0.34109091114932 0.648438220453977 0.692307692307692 11.5 11 5 excessive scratching 0.160775514903549 0.34109091114932 0.648438220453977 0.692307692307692 11.5 11 5 lymphoid hypoplasia 0.160775514903549 0.34109091114932 0.648438220453977 0.692307692307692 11.5 11 5 vestibular hair cell degeneration 0.160775514903549 0.34109091114932 0.648438220453977 0.692307692307692 11.5 11 5 small interparietal bone 0.160775514903549 0.34109091114932 0.648438220453977 0.692307692307692 11.5 11 5 decreased endocochlear potential 0.160775514903549 0.34109091114932 0.648438220453977 0.692307692307692 11.5 11 5 hyperalgesia 0.160775514903549 0.34109091114932 0.648438220453977 0.692307692307692 11.5 11 5 abnormal inhibitory postsynaptic currents 0.00256324972907528 0.0141747137280952 0.647378680878071 0.691176470588235 11.5 11 5 abnormal learning/memory/conditioning 0.00648053881072068 0.030159663782353 0.647128244251039 0.690909090909091 11.5 11 5 decreased IgM level 0.00035999313442935 0.00270130594839519 0.646952680430027 0.690721649484536 11.5 11 5 arrest of spermatogenesis 0.000885982976125029 0.00570954055210106 0.646722775426321 0.69047619047619 11.5 11 5 abnormal muscle morphology 0.0167562678581527 0.0648230424528068 0.646722775426321 0.69047619047619 11.5 11 5 abnormal microglial cell morphology 0.0450101439785891 0.136790144345437 0.645953782827716 0.689655172413793 11.5 11 5 abnormal circulating glucose level 0.0450101439785891 0.136790144345437 0.645953782827716 0.689655172413793 11.5 11 5 decreased granulocyte number 0.0450101439785891 0.136790144345437 0.645953782827716 0.689655172413793 11.5 11 5 absent long term depression 0.0450101439785891 0.136790144345437 0.645953782827716 0.689655172413793 11.5 11 5 increased double-positive T cell number 0.0450101439785891 0.136790144345437 0.645953782827716 0.689655172413793 11.5 11 5 abnormal cytokine secretion 1.05156748986231e-05 0.00012026547728885 0.644695431302727 0.688311688311688 11.5 11 5 abnormal intestinal epithelium morphology 0.0121493145373905 0.0505797822790941 0.64393517725638 0.6875 11.5 11 5 reduced long term potentiation 0.000172055553715393 0.00141250227678891 0.643935177256379 0.6875 11.5 11 5 abnormal crypts of Lieberkuhn morphology 0.0379192066644312 0.121473311755019 0.643935177256379 0.6875 11.5 11 5 abnormal depression-related behavior 0.0379192066644312 0.121473311755019 0.643935177256379 0.6875 11.5 11 5 abnormal serotonin level 0.0379192066644312 0.121473311755019 0.643935177256379 0.6875 11.5 11 5 decreased mast cell number 0.130990544655321 0.294192881845367 0.643935177256379 0.6875 11.5 11 5 mixed cellular infiltration to dermis 0.130990544655321 0.294192881845367 0.643935177256379 0.6875 11.5 11 5 abnormal intestinal absorption 0.130990544655321 0.294192881845367 0.643935177256379 0.6875 11.5 11 5 decreased cochlear coiling 0.130990544655321 0.294192881845367 0.643935177256379 0.6875 11.5 11 5 impaired muscle relaxation 0.130990544655321 0.294192881845367 0.643935177256379 0.6875 11.5 11 5 decreased aggression towards mice 0.130990544655321 0.294192881845367 0.643935177256379 0.6875 11.5 11 5 abnormal molar crown morphology 0.130990544655321 0.294192881845367 0.643935177256379 0.6875 11.5 11 5 small epididymis 0.130990544655321 0.294192881845367 0.643935177256379 0.6875 11.5 11 5 abnormal wound healing 0.130990544655321 0.294192881845367 0.643935177256379 0.6875 11.5 11 5 abnormal level of surface class II molecules 0.130990544655321 0.294192881845367 0.643935177256379 0.6875 11.5 11 5 sepsis 0.130990544655321 0.294192881845367 0.643935177256379 0.6875 11.5 11 5 abnormal intestinal lipid absorption 0.130990544655321 0.294192881845367 0.643935177256379 0.6875 11.5 11 5 dilated respiratory conducting tubes 0.130990544655321 0.294192881845367 0.643935177256379 0.6875 11.5 11 5 abnormal thrombosis 0.0103587114291784 0.0433428001347037 0.642787342715816 0.686274509803922 11.5 11 5 abnormal eye electrophysiology 0.000110554582361479 0.000971747433300985 0.642483783167898 0.685950413223141 11.5 11 5 abnormal action potential 0.00298994509375775 0.0161508977648695 0.642262618354415 0.685714285714286 11.5 11 5 abnormal hippocampus pyramidal cell morphology 0.0320135126188602 0.109537293864395 0.642262618354415 0.685714285714286 11.5 11 5 abnormal retinal outer nuclear layer morphology 0.0270775699012892 0.0932255434317743 0.640854147700129 0.684210526315789 11.5 11 5 short vibrissae 0.107710228943211 0.268870240337419 0.640854147700129 0.684210526315789 11.5 11 5 abnormal long term depression 0.107710228943211 0.268870240337419 0.640854147700129 0.684210526315789 11.5 11 5 decreased fertilization frequency 0.107710228943211 0.268870240337419 0.640854147700129 0.684210526315789 11.5 11 5 decreased susceptibility to weight gain 0.107710228943211 0.268870240337419 0.640854147700129 0.684210526315789 11.5 11 5 decreased liver glycogen level 0.107710228943211 0.268870240337419 0.640854147700129 0.684210526315789 11.5 11 5 shortened RR interval 0.107710228943211 0.268870240337419 0.640854147700129 0.684210526315789 11.5 11 5 right-sided stomach 0.107710228943211 0.268870240337419 0.640854147700129 0.684210526315789 11.5 11 5 short ulna 0.0229397545537097 0.083547056299199 0.639651794702568 0.682926829268293 11.5 11 5 skin lesions 0.00551374147623891 0.0261459907089624 0.639289180306478 0.682539682539683 11.5 11 5 decreased sensitivity to induced morbidity/mortality 0.0194620578424828 0.072095113750076 0.638613398931947 0.681818181818182 11.5 11 5 abnormal oogenesis 0.0891684097905291 0.230839986706357 0.638613398931947 0.681818181818182 11.5 11 5 abnormal channel response 0.0891684097905291 0.230839986706357 0.638613398931947 0.681818181818182 11.5 11 5 abnormal retinal layer morphology 0.0891684097905291 0.230839986706357 0.638613398931947 0.681818181818182 11.5 11 5 decreased circulating estradiol level 0.0891684097905291 0.230839986706357 0.638613398931947 0.681818181818182 11.5 11 5 abnormal temporal bone morphology 0.0891684097905291 0.230839986706357 0.638613398931947 0.681818181818182 11.5 11 5 abnormal heart left ventricle morphology 0.00345727809714564 0.0178237912262172 0.637430781526517 0.680555555555556 11.5 11 5 abnormal excitatory postsynaptic currents 0.00253876439512871 0.0140806609428822 0.636430105260384 0.67948717948718 11.5 11 5 enhanced long term potentiation 0.0101996178792416 0.0427130462535579 0.635572382746556 0.678571428571429 11.5 11 5 abnormal retinal inner nuclear layer morphology 0.0620071278692259 0.183186140825059 0.635572382746556 0.678571428571429 11.5 11 5 corneal vascularization 0.0620071278692259 0.183186140825059 0.635572382746556 0.678571428571429 11.5 11 5 abnormal retinal photoreceptor layer morphology 0.051991064683117 0.155816594456932 0.634493312487224 0.67741935483871 11.5 11 5 decreased double-negative T cell number 0.051991064683117 0.155816594456932 0.634493312487224 0.67741935483871 11.5 11 5 decreased monocyte cell number 0.00634118003272953 0.029538736575683 0.634028482221666 0.676923076923077 11.5 11 5 decreased susceptibility to injury 0.00541961466014403 0.0257768479294613 0.633604666391304 0.676470588235294 11.5 11 5 decreased regulatory T cell number 0.0437162795070592 0.133265006463002 0.633604666391304 0.676470588235294 11.5 11 5 increased susceptibility to weight gain 0.0437162795070592 0.133265006463002 0.633604666391304 0.676470588235294 11.5 11 5 decreased IgG level 0.000476099660239543 0.00342800286058762 0.632860125067695 0.675675675675676 11.5 11 5 obese 0.00339520114371825 0.017705582484275 0.632531366561166 0.675324675324675 11.5 11 5 abnormal skin pigmentation 0.031120627570703 0.106702358486731 0.632227264942627 0.675 11.5 11 5 decreased anxiety-related response 0.000261001872158005 0.00205131803157358 0.63203689238468 0.67479674796748 11.5 11 5 abnormal immune system morphology 0.0223144769639486 0.0814486594979047 0.631209185610996 0.673913043478261 11.5 11 5 abnormal T cell differentiation 0.000994637375550467 0.00638493024950139 0.630604386008048 0.673267326732673 11.5 11 5 increased percent body fat/body weight 0.0160900119731991 0.0624397890535613 0.630426047663588 0.673076923076923 11.5 11 5 rectal prolapse 0.084348130116667 0.219243441656436 0.624421990066792 0.666666666666667 11.5 11 5 wrinkled skin 0.084348130116667 0.219243441656436 0.624421990066792 0.666666666666667 11.5 11 5 decreased susceptibility to pharmacologically induced seizures 0.084348130116667 0.219243441656436 0.624421990066792 0.666666666666667 11.5 11 5 decreased metastatic potential 0.101394450959322 0.257760548555251 0.624421990066792 0.666666666666667 11.5 11 5 curly vibrissae 0.101394450959322 0.257760548555251 0.624421990066792 0.666666666666667 11.5 11 5 increased stereotypic behavior 0.101394450959322 0.257760548555251 0.624421990066792 0.666666666666667 11.5 11 5 apnea 0.101394450959322 0.257760548555251 0.624421990066792 0.666666666666667 11.5 11 5 abnormal tumor morphology 0.101394450959322 0.257760548555251 0.624421990066792 0.666666666666667 11.5 11 5 abnormal adipose tissue distribution 0.226978393976101 0.439384245148288 0.624421990066792 0.666666666666667 11.5 11 5 abnormal supraoccipital bone morphology 0.226978393976101 0.439384245148288 0.624421990066792 0.666666666666667 11.5 11 5 decreased digestive secretion 0.226978393976101 0.439384245148288 0.624421990066792 0.666666666666667 11.5 11 5 abnormal enteric nervous system morphology 0.226978393976101 0.439384245148288 0.624421990066792 0.666666666666667 11.5 11 5 ear inflammation 0.226978393976101 0.439384245148288 0.624421990066792 0.666666666666667 11.5 11 5 abnormal tracheal ciliated epithelium morphology 0.226978393976101 0.439384245148288 0.624421990066792 0.666666666666667 11.5 11 5 increased growth rate 0.226978393976101 0.439384245148288 0.624421990066792 0.666666666666667 11.5 11 5 abnormal AMPA-mediated synaptic currents 0.226978393976101 0.439384245148288 0.624421990066792 0.666666666666667 11.5 11 5 increased circulating parathyroid hormone level 0.226978393976101 0.439384245148288 0.624421990066792 0.666666666666667 11.5 11 5 impaired sperm capacitation 0.226978393976101 0.439384245148288 0.624421990066792 0.666666666666667 11.5 11 5 abnormal defecation 0.226978393976101 0.439384245148288 0.624421990066792 0.666666666666667 11.5 11 5 stria vascularis degeneration 0.226978393976101 0.439384245148288 0.624421990066792 0.666666666666667 11.5 11 5 decreased cochlear nerve compound action potential 0.226978393976101 0.439384245148288 0.624421990066792 0.666666666666667 11.5 11 5 abnormal anogenital distance 0.226978393976101 0.439384245148288 0.624421990066792 0.666666666666667 11.5 11 5 abnormal patella morphology 0.226978393976101 0.439384245148288 0.624421990066792 0.666666666666667 11.5 11 5 impaired behavioral response to cocaine 0.226978393976101 0.439384245148288 0.624421990066792 0.666666666666667 11.5 11 5 decreased oligodendrocyte number 0.226978393976101 0.439384245148288 0.624421990066792 0.666666666666667 11.5 11 5 abnormal vitelline vein connection 0.226978393976101 0.439384245148288 0.624421990066792 0.666666666666667 11.5 11 5 small lens 0.0418181562073027 0.131596810835856 0.624421990066792 0.666666666666667 11.5 11 5 abnormal lens fiber morphology 0.0418181562073027 0.131596810835856 0.624421990066792 0.666666666666667 11.5 11 5 abnormal circulating hormone level 0.0418181562073027 0.131596810835856 0.624421990066792 0.666666666666667 11.5 11 5 absent vibrissae 0.0590516790436398 0.174662368158209 0.624421990066792 0.666666666666667 11.5 11 5 abnormal pain threshold 0.0704563263046914 0.191869745621567 0.624421990066792 0.666666666666667 11.5 11 5 abnormal spleen marginal zone morphology 0.0704563263046914 0.191869745621567 0.624421990066792 0.666666666666667 11.5 11 5 abnormal microglial cell physiology 0.0704563263046914 0.191869745621567 0.624421990066792 0.666666666666667 11.5 11 5 abnormal anxiety-related response 0.122509466198083 0.294192881845367 0.624421990066792 0.666666666666667 11.5 11 5 increased vasoconstriction 0.122509466198083 0.294192881845367 0.624421990066792 0.666666666666667 11.5 11 5 dry skin 0.122509466198083 0.294192881845367 0.624421990066792 0.666666666666667 11.5 11 5 decreased vocalization 0.122509466198083 0.294192881845367 0.624421990066792 0.666666666666667 11.5 11 5 eye inflammation 0.148991726421219 0.317853275705645 0.624421990066792 0.666666666666667 11.5 11 5 decreased activity of thyroid 0.148991726421219 0.317853275705645 0.624421990066792 0.666666666666667 11.5 11 5 increased susceptibility to autoimmune disorder 0.148991726421219 0.317853275705645 0.624421990066792 0.666666666666667 11.5 11 5 decreased tumor latency 0.148991726421219 0.317853275705645 0.624421990066792 0.666666666666667 11.5 11 5 decreased chondrocyte number 0.18277964053111 0.374517591285945 0.624421990066792 0.666666666666667 11.5 11 5 decreased salivation 0.18277964053111 0.374517591285945 0.624421990066792 0.666666666666667 11.5 11 5 hyperpigmentation 0.18277964053111 0.374517591285945 0.624421990066792 0.666666666666667 11.5 11 5 abnormal lymph node B cell domain morphology 0.18277964053111 0.374517591285945 0.624421990066792 0.666666666666667 11.5 11 5 joint inflammation 0.18277964053111 0.374517591285945 0.624421990066792 0.666666666666667 11.5 11 5 increased alcohol consumption 0.18277964053111 0.374517591285945 0.624421990066792 0.666666666666667 11.5 11 5 dilated ureter 0.18277964053111 0.374517591285945 0.624421990066792 0.666666666666667 11.5 11 5 decreased aggression towards males 0.18277964053111 0.374517591285945 0.624421990066792 0.666666666666667 11.5 11 5 abnormal dendritic cell morphology 0.18277964053111 0.374517591285945 0.624421990066792 0.666666666666667 11.5 11 5 bicuspid aortic valve 0.18277964053111 0.374517591285945 0.624421990066792 0.666666666666667 11.5 11 5 thick tail 0.287117583133974 0.474712521133771 0.624421990066792 0.666666666666667 11.5 11 5 abnormal sympathetic neuron morphology 0.287117583133974 0.474712521133771 0.624421990066792 0.666666666666667 11.5 11 5 small geniculate ganglion 0.287117583133974 0.474712521133771 0.624421990066792 0.666666666666667 11.5 11 5 abnormal vagina epithelium morphology 0.287117583133974 0.474712521133771 0.624421990066792 0.666666666666667 11.5 11 5 psoriasis 0.287117583133974 0.474712521133771 0.624421990066792 0.666666666666667 11.5 11 5 abnormal lens vesicle development 0.287117583133974 0.474712521133771 0.624421990066792 0.666666666666667 11.5 11 5 abnormal lung volume 0.287117583133974 0.474712521133771 0.624421990066792 0.666666666666667 11.5 11 5 abnormal taste sensitivity 0.287117583133974 0.474712521133771 0.624421990066792 0.666666666666667 11.5 11 5 abnormal gut-associated lymphoid tissue morphology 0.287117583133974 0.474712521133771 0.624421990066792 0.666666666666667 11.5 11 5 polycythemia 0.287117583133974 0.474712521133771 0.624421990066792 0.666666666666667 11.5 11 5 yellow coat color 0.287117583133974 0.474712521133771 0.624421990066792 0.666666666666667 11.5 11 5 absent posterior semicircular canal 0.287117583133974 0.474712521133771 0.624421990066792 0.666666666666667 11.5 11 5 priapism 0.287117583133974 0.474712521133771 0.624421990066792 0.666666666666667 11.5 11 5 abnormal ovary physiology 0.287117583133974 0.474712521133771 0.624421990066792 0.666666666666667 11.5 11 5 impaired febrile response 0.287117583133974 0.474712521133771 0.624421990066792 0.666666666666667 11.5 11 5 abnormal bony labyrinth 0.287117583133974 0.474712521133771 0.624421990066792 0.666666666666667 11.5 11 5 abnormal proprioceptive neuron morphology 0.287117583133974 0.474712521133771 0.624421990066792 0.666666666666667 11.5 11 5 decreased vestibular hair cell number 0.287117583133974 0.474712521133771 0.624421990066792 0.666666666666667 11.5 11 5 small scapula 0.287117583133974 0.474712521133771 0.624421990066792 0.666666666666667 11.5 11 5 abnormal intervertebral disk development 0.287117583133974 0.474712521133771 0.624421990066792 0.666666666666667 11.5 11 5 increased tidal volume 0.287117583133974 0.474712521133771 0.624421990066792 0.666666666666667 11.5 11 5 abnormal retinal development 0.287117583133974 0.474712521133771 0.624421990066792 0.666666666666667 11.5 11 5 abnormal hippocampus granule cell morphology 0.287117583133974 0.474712521133771 0.624421990066792 0.666666666666667 11.5 11 5 abnormal incisor color 0.287117583133974 0.474712521133771 0.624421990066792 0.666666666666667 11.5 11 5 abnormal heart left ventricle pressure 0.287117583133974 0.474712521133771 0.624421990066792 0.666666666666667 11.5 11 5 abnormal pulmonary alveolar parenchyma morphology 0.287117583133974 0.474712521133771 0.624421990066792 0.666666666666667 11.5 11 5 decreased airway resistance 0.287117583133974 0.474712521133771 0.624421990066792 0.666666666666667 11.5 11 5 abnormal ureteric bud invasion 0.287117583133974 0.474712521133771 0.624421990066792 0.666666666666667 11.5 11 5 increased core body temperature 0.287117583133974 0.474712521133771 0.624421990066792 0.666666666666667 11.5 11 5 decreased bone trabecular spacing 0.287117583133974 0.474712521133771 0.624421990066792 0.666666666666667 11.5 11 5 increased myeloid cell number 0.287117583133974 0.474712521133771 0.624421990066792 0.666666666666667 11.5 11 5 trigeminal neuroma 0.287117583133974 0.474712521133771 0.624421990066792 0.666666666666667 11.5 11 5 increased bone mineralization 0.287117583133974 0.474712521133771 0.624421990066792 0.666666666666667 11.5 11 5 enhanced leukocyte tethering or rolling 0.287117583133974 0.474712521133771 0.624421990066792 0.666666666666667 11.5 11 5 increased endoplasmic reticulum stress 0.287117583133974 0.474712521133771 0.624421990066792 0.666666666666667 11.5 11 5 adipose tissue inflammation 0.287117583133974 0.474712521133771 0.624421990066792 0.666666666666667 11.5 11 5 increased B cell proliferation 0.0174165360746445 0.0671684240088034 0.619130278286565 0.661016949152542 11.5 11 5 short humerus 0.0468980255320472 0.14218018100057 0.616807087748904 0.658536585365854 11.5 11 5 increased double-negative T cell number 0.019418804193145 0.0719884879738424 0.614185564000123 0.655737704918033 11.5 11 5 decreased retinal photoreceptor cell number 0.0943013972614356 0.240466146271472 0.61365609368633 0.655172413793103 11.5 11 5 increased retinal apoptosis 0.0943013972614356 0.240466146271472 0.61365609368633 0.655172413793103 11.5 11 5 abnormal leukocyte migration 0.0316119883300979 0.108237881584472 0.6124138748732 0.653846153846154 11.5 11 5 abnormal tectorial membrane morphology 0.113197385475963 0.281297199172287 0.6124138748732 0.653846153846154 11.5 11 5 abnormal postnatal growth 0.136505245473642 0.294192881845367 0.610847598978384 0.652173913043478 11.5 11 5 abnormal cochlear ganglion morphology 0.136505245473642 0.294192881845367 0.610847598978384 0.652173913043478 11.5 11 5 decreased effector memory CD8-positive, alpha-beta T cell number 0.136505245473642 0.294192881845367 0.610847598978384 0.652173913043478 11.5 11 5 impaired macrophage phagocytosis 0.0520604327273484 0.155930555580107 0.609900548437332 0.651162790697674 11.5 11 5 abnormal eye physiology 0.0252509226142467 0.0872384305596369 0.608811440315122 0.65 11.5 11 5 brain inflammation 0.165561029093623 0.34452700368287 0.608811440315122 0.65 11.5 11 5 decreased skin tensile strength 0.165561029093623 0.34452700368287 0.608811440315122 0.65 11.5 11 5 increased white adipose tissue amount 0.0732399372670294 0.194007016668032 0.607545720064987 0.648648648648649 11.5 11 5 abnormal humoral immune response 0.00444514964487513 0.0222929631887639 0.60658136177917 0.647619047619048 11.5 11 5 thin skin 0.087166578194038 0.226451032122892 0.606056637417769 0.647058823529412 11.5 11 5 abnormal urinary bladder morphology 0.202294992101151 0.408095842460635 0.606056637417769 0.647058823529412 11.5 11 5 abnormal melanosome morphology 0.202294992101151 0.408095842460635 0.606056637417769 0.647058823529412 11.5 11 5 abnormal lymph node morphology 0.0485019107952102 0.146953109747973 0.604908802877205 0.645833333333333 11.5 11 5 decreased susceptibility to bacterial infection induced morbidity/mortality 0.104029529253009 0.264189335392405 0.604279345225928 0.645161290322581 11.5 11 5 increased T cell proliferation 0.00487399116872649 0.024296699463341 0.603996971700122 0.644859813084112 11.5 11 5 altered response to myocardial infarction 0.0572831056977858 0.170751019081177 0.603607923731233 0.644444444444444 11.5 11 5 increased circulating corticosterone level 0.0572831056977858 0.170751019081177 0.603607923731233 0.644444444444444 11.5 11 5 decreased inflammatory response 0.0129720700263369 0.0534681428177516 0.602121204707264 0.642857142857143 11.5 11 5 abnormal cytotoxic T cell physiology 0.0677623611890491 0.191869745621567 0.602121204707264 0.642857142857143 11.5 11 5 abnormal zigzag hair morphology 0.249648746161 0.447515668343032 0.602121204707264 0.642857142857143 11.5 11 5 abnormal spleen periarteriolar lymphoid sheath morphology 0.249648746161 0.447515668343032 0.602121204707264 0.642857142857143 11.5 11 5 abnormal endplate potential 0.249648746161 0.447515668343032 0.602121204707264 0.642857142857143 11.5 11 5 abnormal prepulse inhibition 0.249648746161 0.447515668343032 0.602121204707264 0.642857142857143 11.5 11 5 abnormal imprinting 0.249648746161 0.447515668343032 0.602121204707264 0.642857142857143 11.5 11 5 enlarged stomach 0.249648746161 0.447515668343032 0.602121204707264 0.642857142857143 11.5 11 5 abnormal pancreas development 0.249648746161 0.447515668343032 0.602121204707264 0.642857142857143 11.5 11 5 decreased cornea thickness 0.249648746161 0.447515668343032 0.602121204707264 0.642857142857143 11.5 11 5 abnormal feces composition 0.149733418557326 0.319161849752655 0.599445110464121 0.64 11.5 11 5 decreased placenta weight 0.149733418557326 0.319161849752655 0.599445110464121 0.64 11.5 11 5 abnormal male meiosis 0.0355896779971091 0.119172972996956 0.59883092490012 0.639344262295082 11.5 11 5 impaired wound healing 0.0953620275556379 0.243046151172796 0.598404407147343 0.638888888888889 11.5 11 5 abnormal food intake 0.0282176543494287 0.0969494685002817 0.597273207889975 0.63768115942029 11.5 11 5 abnormal immune system physiology 0.00437847849713513 0.0221377758041095 0.596725853410604 0.637096774193548 11.5 11 5 short femur 0.0153632507867736 0.0597593218641114 0.596039172336484 0.636363636363636 11.5 11 5 abnormal T-helper 2 physiology 0.0490420145248455 0.14849910058497 0.596039172336484 0.636363636363636 11.5 11 5 abnormal gametogenesis 0.0738443037357885 0.194007016668032 0.596039172336484 0.636363636363636 11.5 11 5 decreased macrophage cell number 0.0738443037357885 0.194007016668032 0.596039172336484 0.636363636363636 11.5 11 5 abnormal abdominal fat pad morphology 0.180856314911303 0.372109250075985 0.596039172336484 0.636363636363636 11.5 11 5 abnormal female reproductive system physiology 0.180856314911303 0.372109250075985 0.596039172336484 0.636363636363636 11.5 11 5 abnormal retinal outer plexiform layer morphology 0.180856314911303 0.372109250075985 0.596039172336484 0.636363636363636 11.5 11 5 decreased susceptibility to viral infection induced morbidity/mortality 0.180856314911303 0.372109250075985 0.596039172336484 0.636363636363636 11.5 11 5 rough coat 0.180856314911303 0.372109250075985 0.596039172336484 0.636363636363636 11.5 11 5 increased mast cell number 0.312456103289194 0.513874087227683 0.596039172336484 0.636363636363636 11.5 11 5 decreased post-tetanic potentiation 0.312456103289194 0.513874087227683 0.596039172336484 0.636363636363636 11.5 11 5 variable body spotting 0.312456103289194 0.513874087227683 0.596039172336484 0.636363636363636 11.5 11 5 rectal hemorrhage 0.312456103289194 0.513874087227683 0.596039172336484 0.636363636363636 11.5 11 5 abnormal nerve fiber response 0.312456103289194 0.513874087227683 0.596039172336484 0.636363636363636 11.5 11 5 abnormal lymph circulation 0.312456103289194 0.513874087227683 0.596039172336484 0.636363636363636 11.5 11 5 abnormal ureter development 0.312456103289194 0.513874087227683 0.596039172336484 0.636363636363636 11.5 11 5 abnormal platelet aggregation 0.312456103289194 0.513874087227683 0.596039172336484 0.636363636363636 11.5 11 5 enhanced behavioral response to addictive substance 0.312456103289194 0.513874087227683 0.596039172336484 0.636363636363636 11.5 11 5 decreased palatine bone horizontal plate size 0.312456103289194 0.513874087227683 0.596039172336484 0.636363636363636 11.5 11 5 shortened PR interval 0.312456103289194 0.513874087227683 0.596039172336484 0.636363636363636 11.5 11 5 increased subcutaneous adipose tissue amount 0.312456103289194 0.513874087227683 0.596039172336484 0.636363636363636 11.5 11 5 abnormal phrenic nerve innervation pattern to diaphragm 0.312456103289194 0.513874087227683 0.596039172336484 0.636363636363636 11.5 11 5 decreased colon length 0.312456103289194 0.513874087227683 0.596039172336484 0.636363636363636 11.5 11 5 decreased T cell proliferation 0.00230660497256258 0.0129665081790947 0.594888517563633 0.635135135135135 11.5 11 5 abnormal T cell activation 0.0261941583641737 0.0904343774196836 0.594888517563633 0.635135135135135 11.5 11 5 decreased threshold for auditory brainstem response 0.103422481685306 0.2627818418715 0.591557674800119 0.631578947368421 11.5 11 5 abnormal nail morphology 0.219760007812089 0.428747466221625 0.591557674800119 0.631578947368421 11.5 11 5 flaky skin 0.219760007812089 0.428747466221625 0.591557674800119 0.631578947368421 11.5 11 5 decreased grooming behavior 0.219760007812089 0.428747466221625 0.591557674800119 0.631578947368421 11.5 11 5 maternal imprinting 0.219760007812089 0.428747466221625 0.591557674800119 0.631578947368421 11.5 11 5 osteoarthritis 0.219760007812089 0.428747466221625 0.591557674800119 0.631578947368421 11.5 11 5 abnormal photoreceptor inner segment morphology 0.219760007812089 0.428747466221625 0.591557674800119 0.631578947368421 11.5 11 5 thin interventricular septum 0.219760007812089 0.428747466221625 0.591557674800119 0.631578947368421 11.5 11 5 delayed wound healing 0.0799133758146168 0.208042409564479 0.590486012345771 0.630434782608696 11.5 11 5 polyphagia 0.0622831996794258 0.183783462873751 0.589731879507526 0.62962962962963 11.5 11 5 decreased tumor growth/size 0.0622831996794258 0.183783462873751 0.589731879507526 0.62962962962963 11.5 11 5 abnormal brain commissure morphology 0.162241119586767 0.34405352512539 0.589731879507526 0.62962962962963 11.5 11 5 abnormal intestinal goblet cell morphology 0.122738878244896 0.294192881845367 0.588740733491547 0.628571428571429 11.5 11 5 impaired behavioral response to xenobiotic 0.122738878244896 0.294192881845367 0.588740733491547 0.628571428571429 11.5 11 5 abnormal inflammatory response 0.0413520222038156 0.13097673481893 0.585395615687618 0.625 11.5 11 5 increased susceptibility to bacterial infection induced morbidity/mortality 0.0413520222038156 0.13097673481893 0.585395615687618 0.625 11.5 11 5 impaired ovarian folliculogenesis 0.111334677248981 0.27697273875714 0.585395615687618 0.625 11.5 11 5 abnormal amnion morphology 0.269094800324093 0.451364339720959 0.585395615687618 0.625 11.5 11 5 decreased circulating growth hormone level 0.269094800324093 0.451364339720959 0.585395615687618 0.625 11.5 11 5 abnormal ear pigmentation 0.399602431679938 0.605734947473398 0.585395615687618 0.625 11.5 11 5 schistocytosis 0.399602431679938 0.605734947473398 0.585395615687618 0.625 11.5 11 5 pointed snout 0.399602431679938 0.605734947473398 0.585395615687618 0.625 11.5 11 5 abnormal cecum morphology 0.399602431679938 0.605734947473398 0.585395615687618 0.625 11.5 11 5 absent mammary gland 0.399602431679938 0.605734947473398 0.585395615687618 0.625 11.5 11 5 dermal cysts 0.399602431679938 0.605734947473398 0.585395615687618 0.625 11.5 11 5 dry eyes 0.399602431679938 0.605734947473398 0.585395615687618 0.625 11.5 11 5 abnormal drinking behavior 0.399602431679938 0.605734947473398 0.585395615687618 0.625 11.5 11 5 abnormal circulating calcium level 0.399602431679938 0.605734947473398 0.585395615687618 0.625 11.5 11 5 preneoplasia 0.399602431679938 0.605734947473398 0.585395615687618 0.625 11.5 11 5 abnormal pulmonary circulation 0.399602431679938 0.605734947473398 0.585395615687618 0.625 11.5 11 5 urinary incontinence 0.399602431679938 0.605734947473398 0.585395615687618 0.625 11.5 11 5 hair follicle degeneration 0.399602431679938 0.605734947473398 0.585395615687618 0.625 11.5 11 5 abnormal ovary development 0.399602431679938 0.605734947473398 0.585395615687618 0.625 11.5 11 5 abnormal thermosensation 0.399602431679938 0.605734947473398 0.585395615687618 0.625 11.5 11 5 increased left ventricle systolic pressure 0.399602431679938 0.605734947473398 0.585395615687618 0.625 11.5 11 5 abnormal skin development 0.399602431679938 0.605734947473398 0.585395615687618 0.625 11.5 11 5 abnormal hair follicle melanocyte morphology 0.399602431679938 0.605734947473398 0.585395615687618 0.625 11.5 11 5 abnormal optic choroid morphology 0.399602431679938 0.605734947473398 0.585395615687618 0.625 11.5 11 5 abnormal canal of Schlemm morphology 0.399602431679938 0.605734947473398 0.585395615687618 0.625 11.5 11 5 abnormal vertebral body development 0.399602431679938 0.605734947473398 0.585395615687618 0.625 11.5 11 5 abnormal circulating corticosterone level 0.399602431679938 0.605734947473398 0.585395615687618 0.625 11.5 11 5 increased pulmonary ventilation 0.399602431679938 0.605734947473398 0.585395615687618 0.625 11.5 11 5 enlarged inguinal lymph nodes 0.399602431679938 0.605734947473398 0.585395615687618 0.625 11.5 11 5 urinary bladder inflammation 0.399602431679938 0.605734947473398 0.585395615687618 0.625 11.5 11 5 skin fibrosis 0.399602431679938 0.605734947473398 0.585395615687618 0.625 11.5 11 5 abnormal olfactory bulb glomerular layer morphology 0.399602431679938 0.605734947473398 0.585395615687618 0.625 11.5 11 5 abnormal sensory neuron physiology 0.399602431679938 0.605734947473398 0.585395615687618 0.625 11.5 11 5 decreased susceptibility to weight loss 0.399602431679938 0.605734947473398 0.585395615687618 0.625 11.5 11 5 abnormal circulating serum amyloid protein level 0.399602431679938 0.605734947473398 0.585395615687618 0.625 11.5 11 5 impaired mucociliary clearance 0.399602431679938 0.605734947473398 0.585395615687618 0.625 11.5 11 5 decreased cranium length 0.399602431679938 0.605734947473398 0.585395615687618 0.625 11.5 11 5 increased mammary gland apoptosis 0.399602431679938 0.605734947473398 0.585395615687618 0.625 11.5 11 5 abnormal CD8-positive, alpha-beta T cell physiology 0.174079176363087 0.35890754347549 0.581358404544945 0.620689655172414 11.5 11 5 abnormal CD4-positive, alpha-beta T cell physiology 0.0514417314456207 0.154356220712885 0.580448610484624 0.619718309859155 11.5 11 5 abnormal associative learning 0.235519818798875 0.447515668343032 0.579820419347736 0.619047619047619 11.5 11 5 hypoalgesia 0.235519818798875 0.447515668343032 0.579820419347736 0.619047619047619 11.5 11 5 abnormal bile salt homeostasis 0.235519818798875 0.447515668343032 0.579820419347736 0.619047619047619 11.5 11 5 abnormal tumor vascularization 0.235519818798875 0.447515668343032 0.579820419347736 0.619047619047619 11.5 11 5 decreased pancreatic beta cell number 0.15607062761811 0.332242778091612 0.578508608444234 0.617647058823529 11.5 11 5 increased susceptibility to viral infection induced morbidity/mortality 0.15607062761811 0.332242778091612 0.578508608444234 0.617647058823529 11.5 11 5 abnormal ocular fundus morphology 0.208191071487506 0.408095842460635 0.576389529292424 0.615384615384615 11.5 11 5 abnormal mast cell morphology 0.332903000492184 0.527553831616098 0.576389529292424 0.615384615384615 11.5 11 5 abnormal sympathetic ganglion morphology 0.332903000492184 0.527553831616098 0.576389529292424 0.615384615384615 11.5 11 5 small trigeminal ganglion 0.332903000492184 0.527553831616098 0.576389529292424 0.615384615384615 11.5 11 5 abnormal intercostal muscle morphology 0.332903000492184 0.527553831616098 0.576389529292424 0.615384615384615 11.5 11 5 increased synaptic depression 0.332903000492184 0.527553831616098 0.576389529292424 0.615384615384615 11.5 11 5 abnormal dopaminergic neuron morphology 0.332903000492184 0.527553831616098 0.576389529292424 0.615384615384615 11.5 11 5 abnormal GABAergic neuron morphology 0.332903000492184 0.527553831616098 0.576389529292424 0.615384615384615 11.5 11 5 abnormal insulin secretion 0.332903000492184 0.527553831616098 0.576389529292424 0.615384615384615 11.5 11 5 increased circulating thyroid-stimulating hormone level 0.332903000492184 0.527553831616098 0.576389529292424 0.615384615384615 11.5 11 5 decreased luteinizing hormone level 0.332903000492184 0.527553831616098 0.576389529292424 0.615384615384615 11.5 11 5 abnormal hair follicle inner root sheath morphology 0.332903000492184 0.527553831616098 0.576389529292424 0.615384615384615 11.5 11 5 abnormal photoreceptor outer segment morphology 0.126683287043126 0.294192881845367 0.574752059038752 0.613636363636364 11.5 11 5 abnormal systemic arterial blood pressure 0.165759643613729 0.34452700368287 0.572386824227893 0.611111111111111 11.5 11 5 abnormal retinal rod cell morphology 0.286057266741044 0.474712521133771 0.572386824227893 0.611111111111111 11.5 11 5 thick dermal layer 0.286057266741044 0.474712521133771 0.572386824227893 0.611111111111111 11.5 11 5 decreased heart rate variability 0.286057266741044 0.474712521133771 0.572386824227893 0.611111111111111 11.5 11 5 abnormal sperm axoneme morphology 0.286057266741044 0.474712521133771 0.572386824227893 0.611111111111111 11.5 11 5 decreased fluid intake 0.286057266741044 0.474712521133771 0.572386824227893 0.611111111111111 11.5 11 5 abnormal lymphocyte physiology 0.134112097080314 0.294192881845367 0.570124425713158 0.608695652173913 11.5 11 5 abnormal innervation pattern to muscle 0.249846867369885 0.447515668343032 0.570124425713158 0.608695652173913 11.5 11 5 abnormal corneal stroma morphology 0.249846867369885 0.447515668343032 0.570124425713158 0.608695652173913 11.5 11 5 increased circulating luteinizing hormone level 0.220472587970402 0.429969080812524 0.568670026667972 0.607142857142857 11.5 11 5 abnormal T cell subpopulation ratio 0.1959461570558 0.401330642796462 0.567656354606175 0.606060606060606 11.5 11 5 abnormal intestinal mucosa morphology 0.157066231106562 0.334219204343518 0.566336223548951 0.604651162790698 11.5 11 5 salivary gland inflammation 0.231965433900365 0.447515668343032 0.561979791060113 0.6 11.5 11 5 abnormal seizure response to electrical stimulation 0.349952404605834 0.545943309160873 0.561979791060113 0.6 11.5 11 5 increased airway responsiveness 0.349952404605834 0.545943309160873 0.561979791060113 0.6 11.5 11 5 arthritis 0.349952404605834 0.545943309160873 0.561979791060113 0.6 11.5 11 5 greasy coat 0.349952404605834 0.545943309160873 0.561979791060113 0.6 11.5 11 5 abnormal neurotransmitter secretion 0.349952404605834 0.545943309160873 0.561979791060113 0.6 11.5 11 5 increased cranium width 0.417800997623376 0.625742863104991 0.561979791060113 0.6 11.5 11 5 abnormal grooming behavior 0.417800997623376 0.625742863104991 0.561979791060113 0.6 11.5 11 5 absent trophoblast giant cells 0.417800997623376 0.625742863104991 0.561979791060113 0.6 11.5 11 5 impaired social transmission of food preference 0.417800997623376 0.625742863104991 0.561979791060113 0.6 11.5 11 5 abnormal primordial germ cell migration 0.417800997623376 0.625742863104991 0.561979791060113 0.6 11.5 11 5 abnormal bone healing 0.417800997623376 0.625742863104991 0.561979791060113 0.6 11.5 11 5 delayed dark adaptation 0.417800997623376 0.625742863104991 0.561979791060113 0.6 11.5 11 5 absent CD4-positive, alpha beta T cells 0.417800997623376 0.625742863104991 0.561979791060113 0.6 11.5 11 5 increased left ventricle diastolic pressure 0.417800997623376 0.625742863104991 0.561979791060113 0.6 11.5 11 5 abnormal deltoid tuberosity morphology 0.417800997623376 0.625742863104991 0.561979791060113 0.6 11.5 11 5 decreased cochlear inner hair cell number 0.417800997623376 0.625742863104991 0.561979791060113 0.6 11.5 11 5 abnormal cochlear inner hair cell physiology 0.417800997623376 0.625742863104991 0.561979791060113 0.6 11.5 11 5 decreased prolactin level 0.417800997623376 0.625742863104991 0.561979791060113 0.6 11.5 11 5 absent coat pigmentation 0.417800997623376 0.625742863104991 0.561979791060113 0.6 11.5 11 5 increased T-helper 17 cell number 0.417800997623376 0.625742863104991 0.561979791060113 0.6 11.5 11 5 increased kidney iron level 0.417800997623376 0.625742863104991 0.561979791060113 0.6 11.5 11 5 common ventricle 0.417800997623376 0.625742863104991 0.561979791060113 0.6 11.5 11 5 decreased IgA level 0.155413632182167 0.33112754608406 0.558377356502035 0.596153846153846 11.5 11 5 abnormal single cell response 0.27502736516131 0.461159805081738 0.55504176894826 0.592592592592593 11.5 11 5 impaired humoral immune response 0.314478213303148 0.517028787568791 0.55346494574102 0.590909090909091 11.5 11 5 abnormal leukocyte adhesion 0.224896514378826 0.438424827207938 0.552373298905239 0.58974358974359 11.5 11 5 decreased cytotoxic T cell cytolysis 0.252911199109643 0.447515668343032 0.550960579470699 0.588235294117647 11.5 11 5 abnormal circulating chemokine level 0.36452309778544 0.568317897675513 0.550960579470699 0.588235294117647 11.5 11 5 abnormal ductus venosus valve morphology 0.36452309778544 0.568317897675513 0.550960579470699 0.588235294117647 11.5 11 5 enlarged epididymis 0.286196587747431 0.474712521133771 0.549060715403559 0.586206896551724 11.5 11 5 small lymph nodes 0.326599950824545 0.527553831616098 0.546369241308443 0.583333333333333 11.5 11 5 abnormal retinal ganglion layer morphology 0.326599950824545 0.527553831616098 0.546369241308443 0.583333333333333 11.5 11 5 abnormal cellular extravasation 0.326599950824545 0.527553831616098 0.546369241308443 0.583333333333333 11.5 11 5 abnormal esophagus morphology 0.432124896327525 0.625742863104991 0.546369241308443 0.583333333333333 11.5 11 5 delayed somite formation 0.432124896327525 0.625742863104991 0.546369241308443 0.583333333333333 11.5 11 5 abnormal cochlear outer hair cell physiology 0.432124896327525 0.625742863104991 0.546369241308443 0.583333333333333 11.5 11 5 abnormal B cell proliferation 0.432124896327525 0.625742863104991 0.546369241308443 0.583333333333333 11.5 11 5 abnormal behavioral response to addictive substance 0.432124896327525 0.625742863104991 0.546369241308443 0.583333333333333 11.5 11 5 abnormal respiratory motile cilium morphology 0.432124896327525 0.625742863104991 0.546369241308443 0.583333333333333 11.5 11 5 abnormal T cell proliferation 0.296581716722625 0.490197355712644 0.543851410703335 0.580645161290323 11.5 11 5 decreased susceptibility to induced arthritis 0.208170360230404 0.408095842460635 0.542261201900109 0.578947368421053 11.5 11 5 abnormal response to novelty 0.377215997768356 0.578320366378296 0.542261201900109 0.578947368421053 11.5 11 5 abnormal behavioral response to xenobiotic 0.377215997768356 0.578320366378296 0.542261201900109 0.578947368421053 11.5 11 5 decreased Peyer's patch number 0.337640087768765 0.527728380976942 0.540365183711647 0.576923076923077 11.5 11 5 abnormal T-helper 1 physiology 0.257832218875051 0.447515668343032 0.53806575739798 0.574468085106383 11.5 11 5 abnormal vasoconstriction 0.443908672933764 0.625742863104991 0.535218848628679 0.571428571428571 11.5 11 5 abnormal olfactory system physiology 0.443908672933764 0.625742863104991 0.535218848628679 0.571428571428571 11.5 11 5 decreased vascular permeability 0.443908672933764 0.625742863104991 0.535218848628679 0.571428571428571 11.5 11 5 abnormal hair cuticle 0.443908672933764 0.625742863104991 0.535218848628679 0.571428571428571 11.5 11 5 skeletal muscle necrosis 0.443908672933764 0.625742863104991 0.535218848628679 0.571428571428571 11.5 11 5 abnormal positive T cell selection 0.443908672933764 0.625742863104991 0.535218848628679 0.571428571428571 11.5 11 5 increased susceptibility to age related obesity 0.39849896301639 0.605734947473398 0.529401252447933 0.565217391304348 11.5 11 5 decreased epididymis weight 0.39849896301639 0.605734947473398 0.529401252447933 0.565217391304348 11.5 11 5 increased susceptibility to fungal infection 0.39849896301639 0.605734947473398 0.529401252447933 0.565217391304348 11.5 11 5 abnormal long term potentiation 0.365788800271761 0.57011255681454 0.526856054118856 0.5625 11.5 11 5 abnormal pituitary gland morphology 0.453912181539501 0.625742863104991 0.526856054118856 0.5625 11.5 11 5 abnormal meiosis 0.453912181539501 0.625742863104991 0.526856054118856 0.5625 11.5 11 5 abnormal epididymis epithelium morphology 0.453912181539501 0.625742863104991 0.526856054118856 0.5625 11.5 11 5 decreased circulating prolactin level 0.453912181539501 0.625742863104991 0.526856054118856 0.5625 11.5 11 5 abnormal pancreatic alpha cell morphology 0.453912181539501 0.625742863104991 0.526856054118856 0.5625 11.5 11 5 abnormal Langerhans cell physiology 0.453912181539501 0.625742863104991 0.526856054118856 0.5625 11.5 11 5 loose skin 0.453912181539501 0.625742863104991 0.526856054118856 0.5625 11.5 11 5 arrested B cell differentiation 0.339619312327615 0.530655175511899 0.525428259934252 0.560975609756098 11.5 11 5 decreased acute inflammation 0.407598844430728 0.617668063065145 0.524514471656106 0.56 11.5 11 5 abnormal NK cell physiology 0.30438298874187 0.502924400196214 0.522057729400105 0.557377049180328 11.5 11 5 blepharoptosis 0.462605386590936 0.625742863104991 0.520351658388994 0.555555555555556 11.5 11 5 impaired leukocyte tethering or rolling 0.462605386590936 0.625742863104991 0.520351658388994 0.555555555555556 11.5 11 5 deformed nails 0.540208492362393 0.630433321487897 0.520351658388994 0.555555555555556 11.5 11 5 absent enteric neurons 0.540208492362393 0.630433321487897 0.520351658388994 0.555555555555556 11.5 11 5 small nodose ganglion 0.540208492362393 0.630433321487897 0.520351658388994 0.555555555555556 11.5 11 5 multifocal hepatic necrosis 0.540208492362393 0.630433321487897 0.520351658388994 0.555555555555556 11.5 11 5 abnormal thymus lobule morphology 0.540208492362393 0.630433321487897 0.520351658388994 0.555555555555556 11.5 11 5 enlarged otoliths 0.540208492362393 0.630433321487897 0.520351658388994 0.555555555555556 11.5 11 5 abnormal abdominal wall morphology 0.540208492362393 0.630433321487897 0.520351658388994 0.555555555555556 11.5 11 5 decreased susceptibility to induced choroidal neovascularization 0.540208492362393 0.630433321487897 0.520351658388994 0.555555555555556 11.5 11 5 brittle hair 0.540208492362393 0.630433321487897 0.520351658388994 0.555555555555556 11.5 11 5 abnormal stria vascularis vasculature morphology 0.540208492362393 0.630433321487897 0.520351658388994 0.555555555555556 11.5 11 5 increased circulating progesterone level 0.540208492362393 0.630433321487897 0.520351658388994 0.555555555555556 11.5 11 5 increased stomach mucosa thickness 0.540208492362393 0.630433321487897 0.520351658388994 0.555555555555556 11.5 11 5 abnormal oxygen consumption 0.540208492362393 0.630433321487897 0.520351658388994 0.555555555555556 11.5 11 5 reduced AMPA-mediated synaptic currents 0.540208492362393 0.630433321487897 0.520351658388994 0.555555555555556 11.5 11 5 abnormal olfactory neuron innervation pattern 0.540208492362393 0.630433321487897 0.520351658388994 0.555555555555556 11.5 11 5 decreased bone mineral density of femur 0.540208492362393 0.630433321487897 0.520351658388994 0.555555555555556 11.5 11 5 abnormal Peyer's patch T cell area morphology 0.470297413397717 0.625742863104991 0.515148141805104 0.55 11.5 11 5 abnormal male reproductive system physiology 0.470297413397717 0.625742863104991 0.515148141805104 0.55 11.5 11 5 increased activated T cell number 0.477201518460437 0.625742863104991 0.510890719145557 0.545454545454545 11.5 11 5 abnormal enteric ganglia morphology 0.544214870824394 0.63421620575108 0.510890719145557 0.545454545454545 11.5 11 5 abnormal frequency of paradoxical sleep 0.544214870824394 0.63421620575108 0.510890719145557 0.545454545454545 11.5 11 5 enlarged placenta 0.544214870824394 0.63421620575108 0.510890719145557 0.545454545454545 11.5 11 5 increased motor neuron number 0.544214870824394 0.63421620575108 0.510890719145557 0.545454545454545 11.5 11 5 abnormal Bruch membrane morphology 0.544214870824394 0.63421620575108 0.510890719145557 0.545454545454545 11.5 11 5 abnormal extraembryonic ectoderm morphology 0.544214870824394 0.63421620575108 0.510890719145557 0.545454545454545 11.5 11 5 impaired natural killer cell mediated cytotoxicity 0.389185705349352 0.596487641439626 0.509396886633436 0.543859649122807 11.5 11 5 dystrophic cardiac calcinosis 0.547883774802087 0.638342337152315 0.504340838130871 0.538461538461538 11.5 11 5 abnormal spleen germinal center morphology 0.494527825196042 0.625742863104991 0.501767670589387 0.535714285714286 11.5 11 5 arrested T cell differentiation 0.499468258325045 0.625742863104991 0.499537592053434 0.533333333333333 11.5 11 5 abnormal estrous cycle 0.499468258325045 0.625742863104991 0.499537592053434 0.533333333333333 11.5 11 5 lactation failure 0.551287265308541 0.642157374130178 0.499537592053434 0.533333333333333 11.5 11 5 enlarged sebaceous gland 0.554474900762818 0.645417087340903 0.495864521523629 0.529411764705882 11.5 11 5 decreased vasoconstriction 0.554474900762818 0.645417087340903 0.495864521523629 0.529411764705882 11.5 11 5 abnormal tendon morphology 0.554474900762818 0.645417087340903 0.495864521523629 0.529411764705882 11.5 11 5 altered susceptibility to infection 0.557482485282691 0.648766167083366 0.492964729000099 0.526315789473684 11.5 11 5 impaired conditioned place preference behavior 0.565664841198964 0.657980496835362 0.487049152252098 0.52 11.5 11 5 abnormal stomach mucosa morphology 0.565664841198964 0.657980496835362 0.487049152252098 0.52 11.5 11 5 increased susceptibility to induced arthritis 0.57057965133184 0.663542254646074 0.484465337120787 0.517241379310345 11.5 11 5 abnormal body temperature homeostasis 0.572908489658315 0.666094820296826 0.483423476180742 0.516129032258065 11.5 11 5 increased susceptibility to parasitic infection 0.581722888362778 0.676184899440378 0.478723525717874 0.511111111111111 11.5 11 5 intestinal ulcer 0.643472243385755 0.747611959561918 0.468316492550094 0.5 11.5 11 5 abnormal thymocyte activation 0.644667557167665 0.748825845647707 0.468316492550094 0.5 11.5 11 5 abnormal pilomotor reflex 0.656304845321264 0.760213412217297 0.468316492550094 0.5 11.5 11 5 increased litter size 0.656304845321264 0.760213412217297 0.468316492550094 0.5 11.5 11 5 small thyroid gland 0.656304845321264 0.760213412217297 0.468316492550094 0.5 11.5 11 5 increased fear-related response 0.656304845321264 0.760213412217297 0.468316492550094 0.5 11.5 11 5 increased placenta weight 0.656304845321264 0.760213412217297 0.468316492550094 0.5 11.5 11 5 abnormal amacrine cell morphology 0.656304845321264 0.760213412217297 0.468316492550094 0.5 11.5 11 5 decreased compensatory feeding amount 0.656304845321264 0.760213412217297 0.468316492550094 0.5 11.5 11 5 small petrosal ganglion 0.66261598710141 0.766809615219706 0.468316492550094 0.5 11.5 11 5 intestinal hypoperistalsis 0.66261598710141 0.766809615219706 0.468316492550094 0.5 11.5 11 5 absent inguinal lymph nodes 0.66261598710141 0.766809615219706 0.468316492550094 0.5 11.5 11 5 absent axillary lymph nodes 0.66261598710141 0.766809615219706 0.468316492550094 0.5 11.5 11 5 decreased susceptibility to parasitic infection 0.641725797864404 0.745757029753658 0.468316492550094 0.5 11.5 11 5 abnormal fertilization 0.648662349077581 0.753290192964745 0.468316492550094 0.5 11.5 11 5 abnormal antigen presentation 0.651858876670411 0.756296154719051 0.468316492550094 0.5 11.5 11 5 decreased coping response 0.651858876670411 0.756296154719051 0.468316492550094 0.5 11.5 11 5 increased B-1 B cell number 0.651858876670411 0.756296154719051 0.468316492550094 0.5 11.5 11 5 abnormal respiratory motile cilium physiology 0.651858876670411 0.756296154719051 0.468316492550094 0.5 11.5 11 5 increased acute inflammation 0.72133180829909 0.813562853386528 0.446015707190566 0.476190476190476 11.5 11 5 decreased circulating progesterone level 0.770545484514692 0.834268506085003 0.434865314510802 0.464285714285714 11.5 11 5 increased circulating adrenocorticotropin level 0.749237191480558 0.829635730197704 0.432292146969318 0.461538461538462 11.5 11 5 abnormal afterhyperpolarization 0.749237191480558 0.829635730197704 0.432292146969318 0.461538461538462 11.5 11 5 abnormal retinal inner plexiform layer morphology 0.749237191480558 0.829635730197704 0.432292146969318 0.461538461538462 11.5 11 5 decreased follicle stimulating hormone level 0.749237191480558 0.829635730197704 0.432292146969318 0.461538461538462 11.5 11 5 abnormal circulating cytokine level 0.793126819811019 0.857783897513005 0.421484843295085 0.45 11.5 11 5 increased circulating estradiol level 0.810789793583298 0.874226099496512 0.409776930981332 0.4375 11.5 11 5 abnormal retinal cone cell morphology 0.839314979011705 0.901660984794479 0.407231732652256 0.434782608695652 11.5 11 5 abnormal regulatory T cell physiology 0.839314979011705 0.901660984794479 0.407231732652256 0.434782608695652 11.5 11 5 decreased chemically-elicited antinociception 0.85568676793114 0.918653791639495 0.394371783200079 0.421052631578947 11.5 11 5 nuclear cataracts 0.897393400011221 0.951317316227536 0.374653194040075 0.4 11.5 11 5 decreased alcohol consumption 0.890662901002326 0.944383617324504 0.360243455807765 0.384615384615385 11.5 11 5 increased aggression towards mice 0.945097703409115 0.995102729527094 0.330576347682419 0.352941176470588 11.5 11 5 decreased airway responsiveness 0.98182940404308 1 0.298019586168242 0.318181818181818 11.5 11 5 aminoaciduria 1.90317579489151e-06 3.4430180289401e-05 1.16960859554873 1 11.4 11 4 testis degeneration 1.9466925048684e-05 0.000271282779039783 1.16960859554873 1 11.4 11 4 pale placenta 9.17138012868624e-05 0.00106606579766855 1.16960859554873 1 11.4 11 4 osteosclerosis 0.000432028178312473 0.0040249816237913 1.16960859554873 1 11.4 11 4 abnormal inferior vena cava valve morphology 0.000432028178312473 0.0040249816237913 1.16960859554873 1 11.4 11 4 heart hyperplasia 0.000937623066965351 0.00757252395803997 1.16960859554873 1 11.4 11 4 pancreas cysts 0.000937623066965351 0.00757252395803997 1.16960859554873 1 11.4 11 4 premature bone ossification 0.000937623066965351 0.00757252395803997 1.16960859554873 1 11.4 11 4 increased neuronal precursor cell number 0.000937623066965351 0.00757252395803997 1.16960859554873 1 11.4 11 4 liver hyperplasia 0.000937623066965351 0.00757252395803997 1.16960859554873 1 11.4 11 4 positive geotaxis 0.000937623066965351 0.00757252395803997 1.16960859554873 1 11.4 11 4 eye opacity 0.000937623066965351 0.00757252395803997 1.16960859554873 1 11.4 11 4 axonal spheroids 0.000937623066965351 0.00757252395803997 1.16960859554873 1 11.4 11 4 clubfoot 0.00203483644351144 0.0145869038998119 1.16960859554873 1 11.4 11 4 short ureter 0.00203483644351144 0.0145869038998119 1.16960859554873 1 11.4 11 4 elevated level of mitotic sister chromatid exchange 0.00203483644351144 0.0145869038998119 1.16960859554873 1 11.4 11 4 tau protein deposits 0.00203483644351144 0.0145869038998119 1.16960859554873 1 11.4 11 4 abnormal kidney epithelium morphology 0.00203483644351144 0.0145869038998119 1.16960859554873 1 11.4 11 4 accumulation of giant lysosomes in kidney/renal tubule cells 0.00203483644351144 0.0145869038998119 1.16960859554873 1 11.4 11 4 abnormal somite size 0.00203483644351144 0.0145869038998119 1.16960859554873 1 11.4 11 4 craniofacial phenotype 0.00203483644351144 0.0145869038998119 1.16960859554873 1 11.4 11 4 impaired behavioral response to alcohol 0.00203483644351144 0.0145869038998119 1.16960859554873 1 11.4 11 4 increased caudal vertebrae number 0.00203483644351144 0.0145869038998119 1.16960859554873 1 11.4 11 4 myocardial trabeculae hypoplasia 0.00203483644351144 0.0145869038998119 1.16960859554873 1 11.4 11 4 abnormal visual evoked potential 0.00203483644351144 0.0145869038998119 1.16960859554873 1 11.4 11 4 lung situs inversus 0.00203483644351144 0.0145869038998119 1.16960859554873 1 11.4 11 4 abnormal foramen magnum morphology 0.00203483644351144 0.0145869038998119 1.16960859554873 1 11.4 11 4 impaired neuron differentiation 0.00203483644351144 0.0145869038998119 1.16960859554873 1 11.4 11 4 abnormal umbilical vein topology 0.00203483644351144 0.0145869038998119 1.16960859554873 1 11.4 11 4 abnormal circulating alanine transaminase level 0.0044158645885583 0.027495527319246 1.16960859554873 1 11.4 11 4 decreased cardiomyocyte apoptosis 0.0044158645885583 0.027495527319246 1.16960859554873 1 11.4 11 4 renal necrosis 0.0044158645885583 0.027495527319246 1.16960859554873 1 11.4 11 4 decreased tidal volume 0.0044158645885583 0.027495527319246 1.16960859554873 1 11.4 11 4 decreased brain cholesterol level 0.0044158645885583 0.027495527319246 1.16960859554873 1 11.4 11 4 abnormal T wave 0.0044158645885583 0.027495527319246 1.16960859554873 1 11.4 11 4 decreased CD8-positive, naive alpha-beta T cell number 0.0044158645885583 0.027495527319246 1.16960859554873 1 11.4 11 4 ductus venosus stenosis 0.0044158645885583 0.027495527319246 1.16960859554873 1 11.4 11 4 echinocytosis 0.00958268042960463 0.0509678765261588 1.16960859554873 1 11.4 11 4 abnormal lacrimal gland physiology 0.00958268042960463 0.0509678765261588 1.16960859554873 1 11.4 11 4 non-obstructive hydrocephaly 0.00958268042960463 0.0509678765261588 1.16960859554873 1 11.4 11 4 acidemia 0.00958268042960463 0.0509678765261588 1.16960859554873 1 11.4 11 4 bile duct inflammation 0.00958268042960463 0.0509678765261588 1.16960859554873 1 11.4 11 4 enlarged pancreas 0.00958268042960463 0.0509678765261588 1.16960859554873 1 11.4 11 4 absent cochlear nerve compound action potential 0.00958268042960463 0.0509678765261588 1.16960859554873 1 11.4 11 4 decreased prostate gland weight 0.00958268042960463 0.0509678765261588 1.16960859554873 1 11.4 11 4 decreased platelet ADP level 0.00958268042960463 0.0509678765261588 1.16960859554873 1 11.4 11 4 delayed limb development 0.00958268042960463 0.0509678765261588 1.16960859554873 1 11.4 11 4 thymus cortex atrophy 0.00958268042960463 0.0509678765261588 1.16960859554873 1 11.4 11 4 additional anastomosis between intracranial vertebral arteries 0.00958268042960463 0.0509678765261588 1.16960859554873 1 11.4 11 4 decreased hippocampus volume 0.00958268042960463 0.0509678765261588 1.16960859554873 1 11.4 11 4 absent neurocranium 0.0207942510070859 0.0901101645011464 1.16960859554873 1 11.4 11 4 optic nerve atrophy 0.0207942510070859 0.0901101645011464 1.16960859554873 1 11.4 11 4 kinked vibrissae 0.0207942510070859 0.0901101645011464 1.16960859554873 1 11.4 11 4 vascular inflammation 0.0207942510070859 0.0901101645011464 1.16960859554873 1 11.4 11 4 abnormal respiratory sounds 0.0207942510070859 0.0901101645011464 1.16960859554873 1 11.4 11 4 increased hepatic hemangioma incidence 0.0207942510070859 0.0901101645011464 1.16960859554873 1 11.4 11 4 improved righting response 0.0207942510070859 0.0901101645011464 1.16960859554873 1 11.4 11 4 increased urine microalbumin level 0.0207942510070859 0.0901101645011464 1.16960859554873 1 11.4 11 4 abnormal sebaceous gland physiology 0.0207942510070859 0.0901101645011464 1.16960859554873 1 11.4 11 4 bile duct proliferation 0.0207942510070859 0.0901101645011464 1.16960859554873 1 11.4 11 4 gastric polyps 0.0207942510070859 0.0901101645011464 1.16960859554873 1 11.4 11 4 epidermal cyst 0.0207942510070859 0.0901101645011464 1.16960859554873 1 11.4 11 4 increased activity of parathyroid 0.0207942510070859 0.0901101645011464 1.16960859554873 1 11.4 11 4 sirenomelia 0.0207942510070859 0.0901101645011464 1.16960859554873 1 11.4 11 4 absent vas deferens 0.0207942510070859 0.0901101645011464 1.16960859554873 1 11.4 11 4 absent uterus 0.0207942510070859 0.0901101645011464 1.16960859554873 1 11.4 11 4 abnormal response to vitamins 0.0207942510070859 0.0901101645011464 1.16960859554873 1 11.4 11 4 increased heart right ventricle weight 0.0207942510070859 0.0901101645011464 1.16960859554873 1 11.4 11 4 erythroblastosis 0.0207942510070859 0.0901101645011464 1.16960859554873 1 11.4 11 4 abnormal iris pigment epithelium 0.0207942510070859 0.0901101645011464 1.16960859554873 1 11.4 11 4 abnormal mesangial cell morphology 0.0207942510070859 0.0901101645011464 1.16960859554873 1 11.4 11 4 increased placenta apoptosis 0.0207942510070859 0.0901101645011464 1.16960859554873 1 11.4 11 4 enlarged eye anterior chamber 0.0207942510070859 0.0901101645011464 1.16960859554873 1 11.4 11 4 abnormal arcus anterior morphology 0.0207942510070859 0.0901101645011464 1.16960859554873 1 11.4 11 4 abnormal cerebellum lobule morphology 0.0207942510070859 0.0901101645011464 1.16960859554873 1 11.4 11 4 aciduria 0.0207942510070859 0.0901101645011464 1.16960859554873 1 11.4 11 4 hemolysis 0.0207942510070859 0.0901101645011464 1.16960859554873 1 11.4 11 4 increased response to stress-induced hyperthermia 0.0207942510070859 0.0901101645011464 1.16960859554873 1 11.4 11 4 increased T follicular helper cell number 0.0207942510070859 0.0901101645011464 1.16960859554873 1 11.4 11 4 increased renal carcinoma incidence 0.0207942510070859 0.0901101645011464 1.16960859554873 1 11.4 11 4 calcified aorta 0.0207942510070859 0.0901101645011464 1.16960859554873 1 11.4 11 4 aorta hypoplasia 0.0207942510070859 0.0901101645011464 1.16960859554873 1 11.4 11 4 prolonged ST segment 0.0207942510070859 0.0901101645011464 1.16960859554873 1 11.4 11 4 decreased heart left ventricle size 0.0207942510070859 0.0901101645011464 1.16960859554873 1 11.4 11 4 enlarged aortic valve 0.0207942510070859 0.0901101645011464 1.16960859554873 1 11.4 11 4 abnormal paranode morphology 0.0207942510070859 0.0901101645011464 1.16960859554873 1 11.4 11 4 increased Schwann cell number 0.0207942510070859 0.0901101645011464 1.16960859554873 1 11.4 11 4 impaired branching involved in terminal bronchiole morphogenesis 0.0207942510070859 0.0901101645011464 1.16960859554873 1 11.4 11 4 abnormal eyelid margin morphology 0.0207942510070859 0.0901101645011464 1.16960859554873 1 11.4 11 4 abnormal mitophagy 0.0207942510070859 0.0901101645011464 1.16960859554873 1 11.4 11 4 decreased neuronal precursor proliferation 0.0207942510070859 0.0901101645011464 1.16960859554873 1 11.4 11 4 cystinuria 0.0207942510070859 0.0901101645011464 1.16960859554873 1 11.4 11 4 decreased fibroblast chemotaxis 0.0207942510070859 0.0901101645011464 1.16960859554873 1 11.4 11 4 increased liver adenoma incidence 9.38816025920994e-06 0.000139838614639429 1.10805024841459 0.947368421052632 11.4 11 4 abnormal bile duct morphology 1.93535471615294e-05 0.000270460385192721 1.10463034024047 0.944444444444444 11.4 11 4 abnormal involuntary movement 3.97834409631752e-05 0.000516769239665265 1.10080808992822 0.941176470588235 11.4 11 4 abnormal eyelid morphology 2.48332626197359e-08 6.97997070808962e-07 1.09414997648107 0.935483870967742 11.4 11 4 delayed intramembranous bone ossification 0.000166448811042924 0.00179238708861157 1.09163468917882 0.933333333333333 11.4 11 4 subcutaneous edema 2.08014083198241e-07 4.55889895996144e-06 1.08606512443811 0.928571428571429 11.4 11 4 increased hemangioma incidence 0.000338493728739694 0.00330846031528483 1.08606512443811 0.928571428571429 11.4 11 4 increased pulmonary respiratory rate 0.000338493728739694 0.00330846031528483 1.08606512443811 0.928571428571429 11.4 11 4 abnormal neural tube closure 1.13846671414681e-19 1.82705545254205e-17 1.0850585765934 0.927710843373494 11.4 11 4 decreased circulating fructosamine level 4.20427547104431e-07 8.5372532524267e-06 1.08297092180438 0.925925925925926 11.4 11 4 short hair 0.000685224770124137 0.00592868388063927 1.07963870358345 0.923076923076923 11.4 11 4 abnormal tail bud morphology 0.000685224770124137 0.00592868388063927 1.07963870358345 0.923076923076923 11.4 11 4 abnormal coping response 0.000685224770124137 0.00592868388063927 1.07963870358345 0.923076923076923 11.4 11 4 axonal dystrophy 0.000685224770124137 0.00592868388063927 1.07963870358345 0.923076923076923 11.4 11 4 abnormal exocrine pancreas morphology 0.000685224770124137 0.00592868388063927 1.07963870358345 0.923076923076923 11.4 11 4 abnormal glossopharyngeal nerve morphology 0.00137985101570028 0.0105287711704124 1.07214121258634 0.916666666666667 11.4 11 4 abnormal thymus involution 0.00137985101570028 0.0105287711704124 1.07214121258634 0.916666666666667 11.4 11 4 hematuria 0.00137985101570028 0.0105287711704124 1.07214121258634 0.916666666666667 11.4 11 4 embryonic lethality between implantation and placentation, incomplete penetrance 0.00137985101570028 0.0105287711704124 1.07214121258634 0.916666666666667 11.4 11 4 abnormal vitelline vein connection 0.00137985101570028 0.0105287711704124 1.07214121258634 0.916666666666667 11.4 11 4 abnormal amino acid level 4.27797112857659e-10 1.66272705973973e-08 1.06328054140794 0.909090909090909 11.4 11 4 intracerebral hemorrhage 1.35575191897908e-05 0.000196643317694487 1.06328054140794 0.909090909090909 11.4 11 4 abnormal eye distance/ position 0.00276172426989073 0.0183207920328804 1.06328054140794 0.909090909090909 11.4 11 4 abnormal dorsal-ventral polarity of the somites 0.00276172426989073 0.0183207920328804 1.06328054140794 0.909090909090909 11.4 11 4 aorta dilation 0.00276172426989073 0.0183207920328804 1.06328054140794 0.909090909090909 11.4 11 4 chylous ascites 0.00276172426989073 0.0183207920328804 1.06328054140794 0.909090909090909 11.4 11 4 thin hypoglossal nerve 0.00276172426989073 0.0183207920328804 1.06328054140794 0.909090909090909 11.4 11 4 abnormal head morphology 2.52656819707703e-12 1.42837236141571e-10 1.06328054140794 0.909090909090909 11.4 11 4 abnormal locomotor coordination 7.43505069104546e-08 1.88721312183424e-06 1.06328054140794 0.909090909090909 11.4 11 4 anencephaly 5.30002850567209e-05 0.000665849540800977 1.05264773599386 0.9 11.4 11 4 absent ductus venosus valve 5.30002850567209e-05 0.000665849540800977 1.05264773599386 0.9 11.4 11 4 retarded hair growth 0.00548797706484125 0.0321965635584731 1.05264773599386 0.9 11.4 11 4 increased cranium width 0.00548797706484125 0.0321965635584731 1.05264773599386 0.9 11.4 11 4 abnormal mammary gland physiology 0.00548797706484125 0.0321965635584731 1.05264773599386 0.9 11.4 11 4 abnormal gland morphology 0.00548797706484125 0.0321965635584731 1.05264773599386 0.9 11.4 11 4 ketoaciduria 0.00548797706484125 0.0321965635584731 1.05264773599386 0.9 11.4 11 4 abnormal plasma membrane morphology 0.00548797706484125 0.0321965635584731 1.05264773599386 0.9 11.4 11 4 abnormal deltoid tuberosity morphology 0.00548797706484125 0.0321965635584731 1.05264773599386 0.9 11.4 11 4 abnormal respiratory conducting tube morphology 0.00548797706484125 0.0321965635584731 1.05264773599386 0.9 11.4 11 4 protruding tongue 0.00548797706484125 0.0321965635584731 1.05264773599386 0.9 11.4 11 4 abnormal hippocampus neuron morphology 0.00548797706484125 0.0321965635584731 1.05264773599386 0.9 11.4 11 4 abnormal cerebellar granule cell migration 0.00548797706484125 0.0321965635584731 1.05264773599386 0.9 11.4 11 4 abnormal retinal blood vessel pattern 0.00548797706484125 0.0321965635584731 1.05264773599386 0.9 11.4 11 4 abnormal vibrissa follicle morphology 0.00548797706484125 0.0321965635584731 1.05264773599386 0.9 11.4 11 4 abnormal left subclavian artery morphology 0.00548797706484125 0.0321965635584731 1.05264773599386 0.9 11.4 11 4 abnormal adaptive thermogenesis 0.00548797706484125 0.0321965635584731 1.05264773599386 0.9 11.4 11 4 lethality during fetal growth through weaning, complete penetrance 0.00548797706484125 0.0321965635584731 1.05264773599386 0.9 11.4 11 4 increased fatty acid oxidation 0.00548797706484125 0.0321965635584731 1.05264773599386 0.9 11.4 11 4 abnormal embryonic erythropoiesis 1.12107781127929e-06 2.13692034908601e-05 1.04861460290576 0.896551724137931 11.4 11 4 vertebral transformation 2.88283390260258e-10 1.16602428174373e-08 1.04777436684574 0.895833333333333 11.4 11 4 abnormal circulating amino acid level 6.65227733818111e-12 3.52075316568628e-10 1.04649190128045 0.894736842105263 11.4 11 4 persistence of hyaloid vascular system 2.47945253711555e-08 6.97997070808962e-07 1.04649190128045 0.894736842105263 11.4 11 4 embryonic lethality between implantation and somite formation, incomplete penetrance 0.000104059335831244 0.00119010389829986 1.04649190128045 0.894736842105263 11.4 11 4 increased cellular sensitivity to gamma-irradiation 5.6237766517364e-10 2.13574723987699e-08 1.04518214921376 0.893617021276596 11.4 11 4 decreased cellular sensitivity to gamma-irradiation 0.000203222591376341 0.00210193844510872 1.03965208493221 0.888888888888889 11.4 11 4 absent inner cell mass 0.000203222591376341 0.00210193844510872 1.03965208493221 0.888888888888889 11.4 11 4 abnormal hypoglossal nerve topology 0.000203222591376341 0.00210193844510872 1.03965208493221 0.888888888888889 11.4 11 4 distorted hair follicle pattern 0.0108125434558802 0.054834254529056 1.03965208493221 0.888888888888889 11.4 11 4 synostosis 0.0108125434558802 0.054834254529056 1.03965208493221 0.888888888888889 11.4 11 4 abnormal geniculate ganglion morphology 0.0108125434558802 0.054834254529056 1.03965208493221 0.888888888888889 11.4 11 4 dilated uterus 0.0108125434558802 0.054834254529056 1.03965208493221 0.888888888888889 11.4 11 4 decreased level of surface class I molecules 0.0108125434558802 0.054834254529056 1.03965208493221 0.888888888888889 11.4 11 4 increased pheochromocytoma incidence 0.0108125434558802 0.054834254529056 1.03965208493221 0.888888888888889 11.4 11 4 decreased circulating bicarbonate level 0.0108125434558802 0.054834254529056 1.03965208493221 0.888888888888889 11.4 11 4 biliary cyst 0.0108125434558802 0.054834254529056 1.03965208493221 0.888888888888889 11.4 11 4 abnormal artery development 0.0108125434558802 0.054834254529056 1.03965208493221 0.888888888888889 11.4 11 4 decreased cellular sensitivity to ionizing radiation 0.0108125434558802 0.054834254529056 1.03965208493221 0.888888888888889 11.4 11 4 short frontal bone 0.0108125434558802 0.054834254529056 1.03965208493221 0.888888888888889 11.4 11 4 abnormal posterior eye segment morphology 0.0108125434558802 0.054834254529056 1.03965208493221 0.888888888888889 11.4 11 4 abnormal liver vasculature morphology 0.0108125434558802 0.054834254529056 1.03965208493221 0.888888888888889 11.4 11 4 decreased transitional stage T1 B cell number 0.0108125434558802 0.054834254529056 1.03965208493221 0.888888888888889 11.4 11 4 abnormal telomere morphology 0.0108125434558802 0.054834254529056 1.03965208493221 0.888888888888889 11.4 11 4 retropulsion 0.0108125434558802 0.054834254529056 1.03965208493221 0.888888888888889 11.4 11 4 iris coloboma 0.0108125434558802 0.054834254529056 1.03965208493221 0.888888888888889 11.4 11 4 abnormal oxidative phosphorylation 0.0108125434558802 0.054834254529056 1.03965208493221 0.888888888888889 11.4 11 4 abnormal lung lobe morphology 0.0108125434558802 0.054834254529056 1.03965208493221 0.888888888888889 11.4 11 4 abnormal infrahyoid muscle connection 0.0108125434558802 0.054834254529056 1.03965208493221 0.888888888888889 11.4 11 4 abnormal coronary sinus connection 0.0108125434558802 0.054834254529056 1.03965208493221 0.888888888888889 11.4 11 4 symmetric azygos veins 0.0108125434558802 0.054834254529056 1.03965208493221 0.888888888888889 11.4 11 4 increased cardiac muscle glycogen level 0.0108125434558802 0.054834254529056 1.03965208493221 0.888888888888889 11.4 11 4 decreased platelet dense granule number 0.0108125434558802 0.054834254529056 1.03965208493221 0.888888888888889 11.4 11 4 abnormal Mullerian duct morphology 8.26463825336345e-06 0.000126343896389704 1.0346537576008 0.884615384615385 11.4 11 4 increased thymocyte apoptosis 8.26463825336345e-06 0.000126343896389704 1.0346537576008 0.884615384615385 11.4 11 4 abnormal interatrial septum morphology 0.0003945450614138 0.00374591923765965 1.03200758430771 0.882352941176471 11.4 11 4 abnormal primitive streak morphology 1.59484017114197e-05 0.000227997984236532 1.02925556408289 0.88 11.4 11 4 abnormal egg cylinder morphology 1.59484017114197e-05 0.000227997984236532 1.02925556408289 0.88 11.4 11 4 thick ventricular wall 2.93567718468186e-08 8.20505280550127e-07 1.02697340096962 0.878048780487805 11.4 11 4 decreased cell proliferation 2.24361882483297e-32 8.58615665657231e-30 1.02419779718322 0.875675675675676 11.4 11 4 increased hemangiosarcoma incidence 3.06275736466676e-05 0.000407412243027196 1.02340752110514 0.875 11.4 11 4 failure of tooth eruption 0.000760949772994764 0.00642737711485391 1.02340752110514 0.875 11.4 11 4 abnormal hair follicle orientation 0.000760949772994764 0.00642737711485391 1.02340752110514 0.875 11.4 11 4 disorganized yolk sac vascular plexus 0.000760949772994764 0.00642737711485391 1.02340752110514 0.875 11.4 11 4 decreased creatinine clearance 0.000760949772994764 0.00642737711485391 1.02340752110514 0.875 11.4 11 4 schistocytosis 0.0210830616038863 0.0901101645011464 1.02340752110514 0.875 11.4 11 4 enlarged pituitary gland 0.0210830616038863 0.0901101645011464 1.02340752110514 0.875 11.4 11 4 increased sensitivity to skin irradiation 0.0210830616038863 0.0901101645011464 1.02340752110514 0.875 11.4 11 4 abnormal pupil morphology 0.0210830616038863 0.0901101645011464 1.02340752110514 0.875 11.4 11 4 abnormal urination 0.0210830616038863 0.0901101645011464 1.02340752110514 0.875 11.4 11 4 early eyelid opening 0.0210830616038863 0.0901101645011464 1.02340752110514 0.875 11.4 11 4 abnormal neuron apoptosis 0.0210830616038863 0.0901101645011464 1.02340752110514 0.875 11.4 11 4 decreased susceptibility to age related obesity 0.0210830616038863 0.0901101645011464 1.02340752110514 0.875 11.4 11 4 colon polyps 0.0210830616038863 0.0901101645011464 1.02340752110514 0.875 11.4 11 4 liver cysts 0.0210830616038863 0.0901101645011464 1.02340752110514 0.875 11.4 11 4 binucleate 0.0210830616038863 0.0901101645011464 1.02340752110514 0.875 11.4 11 4 lymph node inflammation 0.0210830616038863 0.0901101645011464 1.02340752110514 0.875 11.4 11 4 abnormal extraembryonic tissue physiology 0.0210830616038863 0.0901101645011464 1.02340752110514 0.875 11.4 11 4 Sertoli cell hypoplasia 0.0210830616038863 0.0901101645011464 1.02340752110514 0.875 11.4 11 4 ocular hypertension 0.0210830616038863 0.0901101645011464 1.02340752110514 0.875 11.4 11 4 stomach epithelial hyperplasia 0.0210830616038863 0.0901101645011464 1.02340752110514 0.875 11.4 11 4 hypergranulosis 0.0210830616038863 0.0901101645011464 1.02340752110514 0.875 11.4 11 4 abnormal mitotic spindle assembly checkpoint 0.0210830616038863 0.0901101645011464 1.02340752110514 0.875 11.4 11 4 abnormal sphingomyelin level 0.0210830616038863 0.0901101645011464 1.02340752110514 0.875 11.4 11 4 abnormal cerebellum deep nucleus morphology 0.0210830616038863 0.0901101645011464 1.02340752110514 0.875 11.4 11 4 abnormal brain ependyma morphology 0.0210830616038863 0.0901101645011464 1.02340752110514 0.875 11.4 11 4 abnormal hepatic vein morphology 0.0210830616038863 0.0901101645011464 1.02340752110514 0.875 11.4 11 4 anomalous pulmonary venous connection 0.0210830616038863 0.0901101645011464 1.02340752110514 0.875 11.4 11 4 delayed suture closure 0.0210830616038863 0.0901101645011464 1.02340752110514 0.875 11.4 11 4 decreased alveolar lamellar body number 0.0210830616038863 0.0901101645011464 1.02340752110514 0.875 11.4 11 4 abnormal bronchiole epithelium morphology 0.0210830616038863 0.0901101645011464 1.02340752110514 0.875 11.4 11 4 increased circulating ferritin level 0.0210830616038863 0.0901101645011464 1.02340752110514 0.875 11.4 11 4 prolonged PQ interval 0.0210830616038863 0.0901101645011464 1.02340752110514 0.875 11.4 11 4 increased circulating lactate level 0.0210830616038863 0.0901101645011464 1.02340752110514 0.875 11.4 11 4 decreased white adipose tissue mass 0.0210830616038863 0.0901101645011464 1.02340752110514 0.875 11.4 11 4 decreased basal metabolism 0.0210830616038863 0.0901101645011464 1.02340752110514 0.875 11.4 11 4 abnormal cell nucleus morphology 4.73028034287057e-09 1.52812627959617e-07 1.02029685994677 0.872340425531915 11.4 11 4 inner cell mass degeneration 2.46937732823792e-06 4.22170178968511e-05 1.01869135741341 0.870967741935484 11.4 11 4 pale kidney 2.46937732823792e-06 4.22170178968511e-05 1.01869135741341 0.870967741935484 11.4 11 4 embryonic lethality between implantation and placentation, complete penetrance 8.99228624031824e-09 2.77034661507021e-07 1.01705095265107 0.869565217391304 11.4 11 4 dilated heart 5.85105742568935e-05 0.000720520066653577 1.01705095265107 0.869565217391304 11.4 11 4 decreased hair follicle number 2.03629912545523e-07 4.48256112793795e-06 1.01571272771337 0.868421052631579 11.4 11 4 abnormal mesoderm development 7.6201191265261e-10 2.78750681282848e-08 1.01513198858947 0.867924528301887 11.4 11 4 disorganized myocardium 4.69214830671302e-06 7.53014123416041e-05 1.0136607828089 0.866666666666667 11.4 11 4 vagina atresia 0.00145678569376871 0.0109644611596056 1.0136607828089 0.866666666666667 11.4 11 4 abnormal placenta size 0.00145678569376871 0.0109644611596056 1.0136607828089 0.866666666666667 11.4 11 4 immune system phenotype 0.00145678569376871 0.0109644611596056 1.0136607828089 0.866666666666667 11.4 11 4 heterochrony 0.00145678569376871 0.0109644611596056 1.0136607828089 0.866666666666667 11.4 11 4 pale liver 4.80785064844488e-13 2.9169581678065e-11 1.01155337993404 0.864864864864865 11.4 11 4 increased circulating phosphate level 3.85598037557993e-07 7.95838172474681e-06 1.01155337993404 0.864864864864865 11.4 11 4 abnormal enterocyte morphology 0.000111143385417934 0.00124816781592375 1.01011651433754 0.863636363636364 11.4 11 4 embryonic lethality before implantation, incomplete penetrance 0.000111143385417934 0.00124816781592375 1.01011651433754 0.863636363636364 11.4 11 4 increased mortality induced by gamma-irradiation 8.87467684034372e-06 0.000132587138981111 1.00828327202477 0.862068965517241 11.4 11 4 blood in lymph vessels 8.87467684034372e-06 0.000132587138981111 1.00828327202477 0.862068965517241 11.4 11 4 abnormal lysosome morphology 7.27351500626008e-07 1.41350535766187e-05 1.00716295727808 0.861111111111111 11.4 11 4 abnormal cell morphology 7.28559728444378e-19 1.03559561400308e-16 1.00545300319102 0.859649122807018 11.4 11 4 increased embryonic tissue cell apoptosis 2.75772370909409e-13 1.71495943159289e-11 1.00466379361237 0.858974358974359 11.4 11 4 abnormal embryo size 1.3649391547105e-18 1.76603664093925e-16 1.00400029883387 0.858407079646018 11.4 11 4 abnormal pancreas morphology 1.13738352306123e-07 2.64846267564609e-06 1.00252165332749 0.857142857142857 11.4 11 4 abnormal midbrain development 1.36638916073166e-06 2.53648734128359e-05 1.00252165332749 0.857142857142857 11.4 11 4 decreased glycogen level 1.36638916073166e-06 2.53648734128359e-05 1.00252165332749 0.857142857142857 11.4 11 4 abnormal somite shape 1.67028066524807e-05 0.00023667972935234 1.00252165332749 0.857142857142857 11.4 11 4 premature aging 1.67028066524807e-05 0.00023667972935234 1.00252165332749 0.857142857142857 11.4 11 4 abnormal erythrocyte physiology 0.000209813898798912 0.00215666145976154 1.00252165332749 0.857142857142857 11.4 11 4 vascular ring 0.000209813898798912 0.00215666145976154 1.00252165332749 0.857142857142857 11.4 11 4 embryonic lethality at implantation, complete penetrance 0.000209813898798912 0.00215666145976154 1.00252165332749 0.857142857142857 11.4 11 4 midline facial cleft 0.0027656110184308 0.0183207920328804 1.00252165332749 0.857142857142857 11.4 11 4 abnormal blood flow velocity 0.0027656110184308 0.0183207920328804 1.00252165332749 0.857142857142857 11.4 11 4 translucent skin 0.0027656110184308 0.0183207920328804 1.00252165332749 0.857142857142857 11.4 11 4 irregularly shaped pupil 0.0027656110184308 0.0183207920328804 1.00252165332749 0.857142857142857 11.4 11 4 abnormal placing response 0.0027656110184308 0.0183207920328804 1.00252165332749 0.857142857142857 11.4 11 4 amyloid beta deposits 0.0027656110184308 0.0183207920328804 1.00252165332749 0.857142857142857 11.4 11 4 failure of zygotic cell division 0.0027656110184308 0.0183207920328804 1.00252165332749 0.857142857142857 11.4 11 4 absent olfactory bulb 0.0027656110184308 0.0183207920328804 1.00252165332749 0.857142857142857 11.4 11 4 vascular smooth muscle hypoplasia 0.0027656110184308 0.0183207920328804 1.00252165332749 0.857142857142857 11.4 11 4 split sternum 0.0027656110184308 0.0183207920328804 1.00252165332749 0.857142857142857 11.4 11 4 lysosomal protein accumulation 0.0027656110184308 0.0183207920328804 1.00252165332749 0.857142857142857 11.4 11 4 multiple persisting craniopharyngeal ducts 0.0027656110184308 0.0183207920328804 1.00252165332749 0.857142857142857 11.4 11 4 asymmetric rib joints 0.0405835754758826 0.150659946665654 1.00252165332749 0.857142857142857 11.4 11 4 cellular necrosis 0.0405835754758826 0.150659946665654 1.00252165332749 0.857142857142857 11.4 11 4 broad head 0.0405835754758826 0.150659946665654 1.00252165332749 0.857142857142857 11.4 11 4 mammary gland hyperplasia 0.0405835754758826 0.150659946665654 1.00252165332749 0.857142857142857 11.4 11 4 abnormal oculomotor nerve morphology 0.0405835754758826 0.150659946665654 1.00252165332749 0.857142857142857 11.4 11 4 absent epidermis stratum corneum 0.0405835754758826 0.150659946665654 1.00252165332749 0.857142857142857 11.4 11 4 limp posture 0.0405835754758826 0.150659946665654 1.00252165332749 0.857142857142857 11.4 11 4 abnormal circulating free fatty acids level 0.0405835754758826 0.150659946665654 1.00252165332749 0.857142857142857 11.4 11 4 abnormal axial mesoderm 0.0405835754758826 0.150659946665654 1.00252165332749 0.857142857142857 11.4 11 4 decreased activated T cell number 0.0405835754758826 0.150659946665654 1.00252165332749 0.857142857142857 11.4 11 4 abnormal tumor incidence 0.0405835754758826 0.150659946665654 1.00252165332749 0.857142857142857 11.4 11 4 abnormal brain ventricular system morphology 0.0405835754758826 0.150659946665654 1.00252165332749 0.857142857142857 11.4 11 4 decreased mortality induced by ionizing radiation 0.0405835754758826 0.150659946665654 1.00252165332749 0.857142857142857 11.4 11 4 aorta coarctation 0.0405835754758826 0.150659946665654 1.00252165332749 0.857142857142857 11.4 11 4 increased cell nucleus count 0.0405835754758826 0.150659946665654 1.00252165332749 0.857142857142857 11.4 11 4 abnormal Purkinje cell innervation 0.0405835754758826 0.150659946665654 1.00252165332749 0.857142857142857 11.4 11 4 increased ectoderm apoptosis 0.0405835754758826 0.150659946665654 1.00252165332749 0.857142857142857 11.4 11 4 abnormal optic tract morphology 0.0405835754758826 0.150659946665654 1.00252165332749 0.857142857142857 11.4 11 4 abnormal vestibular saccular macula morphology 0.0405835754758826 0.150659946665654 1.00252165332749 0.857142857142857 11.4 11 4 urolithiasis 0.0405835754758826 0.150659946665654 1.00252165332749 0.857142857142857 11.4 11 4 increased chronic myelocytic leukemia incidence 0.0405835754758826 0.150659946665654 1.00252165332749 0.857142857142857 11.4 11 4 abnormal renal/urinary system physiology 0.0405835754758826 0.150659946665654 1.00252165332749 0.857142857142857 11.4 11 4 abnormal renal filtration rate 0.0405835754758826 0.150659946665654 1.00252165332749 0.857142857142857 11.4 11 4 increased keratinocyte apoptosis 0.0405835754758826 0.150659946665654 1.00252165332749 0.857142857142857 11.4 11 4 uremia 0.0405835754758826 0.150659946665654 1.00252165332749 0.857142857142857 11.4 11 4 abnormal sperm annulus morphology 0.0405835754758826 0.150659946665654 1.00252165332749 0.857142857142857 11.4 11 4 abnormal cerebellum white matter morphology 0.0405835754758826 0.150659946665654 1.00252165332749 0.857142857142857 11.4 11 4 arteritis 0.0405835754758826 0.150659946665654 1.00252165332749 0.857142857142857 11.4 11 4 abnormal retina inner limiting membrane morphology 0.0405835754758826 0.150659946665654 1.00252165332749 0.857142857142857 11.4 11 4 coronary fistula 0.0405835754758826 0.150659946665654 1.00252165332749 0.857142857142857 11.4 11 4 abnormal aortic valve cusp morphology 0.0405835754758826 0.150659946665654 1.00252165332749 0.857142857142857 11.4 11 4 altered tumor pathology 0.0405835754758826 0.150659946665654 1.00252165332749 0.857142857142857 11.4 11 4 abnormal tricarboxylic acid cycle 0.0405835754758826 0.150659946665654 1.00252165332749 0.857142857142857 11.4 11 4 increased compact bone volume 0.0405835754758826 0.150659946665654 1.00252165332749 0.857142857142857 11.4 11 4 abnormal outer hair cell kinocilium morphology 0.0405835754758826 0.150659946665654 1.00252165332749 0.857142857142857 11.4 11 4 small tail bud 0.0405835754758826 0.150659946665654 1.00252165332749 0.857142857142857 11.4 11 4 decreased volumetric bone mineral density 0.0405835754758826 0.150659946665654 1.00252165332749 0.857142857142857 11.4 11 4 decreased areal bone mineral density 0.0405835754758826 0.150659946665654 1.00252165332749 0.857142857142857 11.4 11 4 absent connection between subcutaneous lymph vessels and lymph sac 0.0405835754758826 0.150659946665654 1.00252165332749 0.857142857142857 11.4 11 4 embryo tumor 0.0405835754758826 0.150659946665654 1.00252165332749 0.857142857142857 11.4 11 4 decreased embryo size 2.81002244791634e-73 4.65995389279459e-70 1.00077388196534 0.855648535564854 11.4 11 4 abnormal endoderm development 2.55576465689109e-06 4.31014548068921e-05 0.997607331497449 0.852941176470588 11.4 11 4 abnormal brown adipose tissue morphology 2.55576465689109e-06 4.31014548068921e-05 0.997607331497449 0.852941176470588 11.4 11 4 abnormal direction of heart looping 2.55576465689109e-06 4.31014548068921e-05 0.997607331497449 0.852941176470588 11.4 11 4 abnormal chondrocyte morphology 2.83315440548734e-09 9.39662877819967e-08 0.996333248060032 0.851851851851852 11.4 11 4 abnormal trigeminal ganglion morphology 3.12699139959322e-05 0.000412646743049769 0.996333248060032 0.851851851851852 11.4 11 4 abnormal eye muscle morphology 3.12699139959322e-05 0.000412646743049769 0.996333248060032 0.851851851851852 11.4 11 4 kidney cysts 3.34074561932013e-12 1.84668993956863e-10 0.995747858372571 0.851351351351351 11.4 11 4 decreased myocardial infarction size 0.000393393956886879 0.00374213180786276 0.994167306216423 0.85 11.4 11 4 dilated vasculature 0.000393393956886879 0.00374213180786276 0.994167306216423 0.85 11.4 11 4 abnormal neuron proliferation 0.000393393956886879 0.00374213180786276 0.994167306216423 0.85 11.4 11 4 increased skin tumor incidence 0.000393393956886879 0.00374213180786276 0.994167306216423 0.85 11.4 11 4 increased circulating bilirubin level 5.26150953145875e-09 1.68877483348434e-07 0.993063901881 0.849056603773585 11.4 11 4 failure to gastrulate 6.18919229080769e-08 1.59540060345949e-06 0.991624678834796 0.847826086956522 11.4 11 4 abnormal hepatocyte morphology 3.17171156498308e-17 3.35729043314699e-15 0.990479351185414 0.846846846846847 11.4 11 4 abnormal nasal bone morphology 5.82091007307298e-05 0.000718586293139903 0.989668811618159 0.846153846153846 11.4 11 4 increased foot pad pigmentation 0.00520029536636907 0.0313974143782599 0.989668811618159 0.846153846153846 11.4 11 4 increased pituitary adenoma incidence 0.00520029536636907 0.0313974143782599 0.989668811618159 0.846153846153846 11.4 11 4 abnormal telomere length 0.00520029536636907 0.0313974143782599 0.989668811618159 0.846153846153846 11.4 11 4 increased circulating ammonia level 0.00520029536636907 0.0313974143782599 0.989668811618159 0.846153846153846 11.4 11 4 absent hypoglossal nerve 0.00520029536636907 0.0313974143782599 0.989668811618159 0.846153846153846 11.4 11 4 preweaning lethality, complete penetrance 1.93770194696657e-106 9.64006718615871e-103 0.987845097591836 0.844594594594595 11.4 11 4 abnormal ectoderm development 1.14456175932444e-07 2.64846267564609e-06 0.987669480685597 0.844444444444444 11.4 11 4 abnormal myocardial trabeculae morphology 1.14456175932444e-07 2.64846267564609e-06 0.987669480685597 0.844444444444444 11.4 11 4 abnormal embryonic hematopoiesis 8.81653517318455e-06 0.000132514388177019 0.986857252494244 0.84375 11.4 11 4 pancreatic islet hyperplasia 8.81653517318455e-06 0.000132514388177019 0.986857252494244 0.84375 11.4 11 4 increased fibroblast apoptosis 8.81653517318455e-06 0.000132514388177019 0.986857252494244 0.84375 11.4 11 4 abnormal cell cycle 1.74236787813072e-17 1.88440873776095e-15 0.986539424071541 0.843478260869565 11.4 11 4 abnormal gastrulation 1.79730192404753e-08 5.16854166019448e-07 0.986140580560697 0.843137254901961 11.4 11 4 irregular coat pigmentation 0.000732093287616855 0.0062259215485365 0.984933554146302 0.842105263157895 11.4 11 4 abnormal digestive system development 0.000732093287616855 0.0062259215485365 0.984933554146302 0.842105263157895 11.4 11 4 oliguria 0.000732093287616855 0.0062259215485365 0.984933554146302 0.842105263157895 11.4 11 4 abnormal blastocyst morphology 0.000732093287616855 0.0062259215485365 0.984933554146302 0.842105263157895 11.4 11 4 decreased liver regeneration 0.000732093287616855 0.0062259215485365 0.984933554146302 0.842105263157895 11.4 11 4 ruffled hair 0.000107693226306718 0.00121490657794994 0.982471220260936 0.84 11.4 11 4 abnormal preimplantation embryo development 0.000107693226306718 0.00121490657794994 0.982471220260936 0.84 11.4 11 4 lethality throughout fetal growth and development, incomplete penetrance 1.1614564275983e-25 3.04118196173765e-23 0.980118934817375 0.837988826815642 11.4 11 4 malocclusion 2.4930777264774e-06 4.24762386617297e-05 0.979942336811101 0.837837837837838 11.4 11 4 kidney failure 3.86921290849949e-07 7.95838172474681e-06 0.979207196273358 0.837209302325581 11.4 11 4 decreased circulating total protein level 9.54006047617271e-09 2.87647277993692e-07 0.978218098095304 0.836363636363636 11.4 11 4 astrocytosis 3.82850436831674e-11 1.73152811203416e-09 0.977344168883189 0.835616438356164 11.4 11 4 abnormal vitelline vasculature morphology 1.05857870141438e-16 1.03263314500717e-14 0.97636891454503 0.834782608695652 11.4 11 4 abnormal forebrain development 6.974511415456e-11 3.01723428625162e-09 0.974673829623945 0.833333333333333 11.4 11 4 absent mesoderm 2.75374264462648e-09 9.31963922246035e-08 0.974673829623945 0.833333333333333 11.4 11 4 small heart 1.10557551579021e-07 2.60327763361892e-06 0.974673829623945 0.833333333333333 11.4 11 4 disheveled coat 7.0703264906543e-07 1.37940683494138e-05 0.974673829623945 0.833333333333333 11.4 11 4 abnormal trophoblast giant cell morphology 4.56157746125988e-06 7.34428733649447e-05 0.974673829623945 0.833333333333333 11.4 11 4 abnormal brain vasculature morphology 2.97873195084977e-05 0.000398365361706387 0.974673829623945 0.833333333333333 11.4 11 4 ocular hypertelorism 0.000197925577308023 0.00205999947093601 0.974673829623945 0.833333333333333 11.4 11 4 abnormal primitive streak formation 0.000197925577308023 0.00205999947093601 0.974673829623945 0.833333333333333 11.4 11 4 right pulmonary isomerism 0.0013511574116011 0.0104704176366285 0.974673829623945 0.833333333333333 11.4 11 4 acidosis 0.0013511574116011 0.0104704176366285 0.974673829623945 0.833333333333333 11.4 11 4 abnormal body wall morphology 0.0013511574116011 0.0104704176366285 0.974673829623945 0.833333333333333 11.4 11 4 jerky movement 0.0013511574116011 0.0104704176366285 0.974673829623945 0.833333333333333 11.4 11 4 decreased lactate dehydrogenase level 0.0013511574116011 0.0104704176366285 0.974673829623945 0.833333333333333 11.4 11 4 abnormal aerobic respiration 0.0013511574116011 0.0104704176366285 0.974673829623945 0.833333333333333 11.4 11 4 abnormal mineral level 0.00967109054084301 0.0509678765261588 0.974673829623945 0.833333333333333 11.4 11 4 mesocardia 0.00967109054084301 0.0509678765261588 0.974673829623945 0.833333333333333 11.4 11 4 impaired embryo implantation 0.00967109054084301 0.0509678765261588 0.974673829623945 0.833333333333333 11.4 11 4 abnormal embryonic growth/weight/body size 0.00967109054084301 0.0509678765261588 0.974673829623945 0.833333333333333 11.4 11 4 altered tumor susceptibility 0.00967109054084301 0.0509678765261588 0.974673829623945 0.833333333333333 11.4 11 4 loss of dopaminergic neurons 0.00967109054084301 0.0509678765261588 0.974673829623945 0.833333333333333 11.4 11 4 dilated bile duct 0.00967109054084301 0.0509678765261588 0.974673829623945 0.833333333333333 11.4 11 4 absent ovary 0.00967109054084301 0.0509678765261588 0.974673829623945 0.833333333333333 11.4 11 4 increased osteosarcoma incidence 0.00967109054084301 0.0509678765261588 0.974673829623945 0.833333333333333 11.4 11 4 abnormal rostral-caudal body axis extension 0.00967109054084301 0.0509678765261588 0.974673829623945 0.833333333333333 11.4 11 4 hemoperitoneum 0.00967109054084301 0.0509678765261588 0.974673829623945 0.833333333333333 11.4 11 4 decreased renal glomerular filtration rate 0.00967109054084301 0.0509678765261588 0.974673829623945 0.833333333333333 11.4 11 4 decreased red blood cell distribution width 0.00967109054084301 0.0509678765261588 0.974673829623945 0.833333333333333 11.4 11 4 increased skeletal muscle glycogen level 0.00967109054084301 0.0509678765261588 0.974673829623945 0.833333333333333 11.4 11 4 abnormal pulmonary valve cusp morphology 0.00967109054084301 0.0509678765261588 0.974673829623945 0.833333333333333 11.4 11 4 prenatal growth retardation 0.00967109054084301 0.0509678765261588 0.974673829623945 0.833333333333333 11.4 11 4 arrest of tooth development 0.0768521038944922 0.236157638588696 0.974673829623945 0.833333333333333 11.4 11 4 hemoglobinuria 0.0768521038944922 0.236157638588696 0.974673829623945 0.833333333333333 11.4 11 4 thin tail 0.0768521038944922 0.236157638588696 0.974673829623945 0.833333333333333 11.4 11 4 abnormal lens induction 0.0768521038944922 0.236157638588696 0.974673829623945 0.833333333333333 11.4 11 4 increased embryo size 0.0768521038944922 0.236157638588696 0.974673829623945 0.833333333333333 11.4 11 4 absent ectoplacental cone 0.0768521038944922 0.236157638588696 0.974673829623945 0.833333333333333 11.4 11 4 delayed brain development 0.0768521038944922 0.236157638588696 0.974673829623945 0.833333333333333 11.4 11 4 chromatolysis 0.0768521038944922 0.236157638588696 0.974673829623945 0.833333333333333 11.4 11 4 abnormal sebaceous lipid secretion 0.0768521038944922 0.236157638588696 0.974673829623945 0.833333333333333 11.4 11 4 liver cirrhosis 0.0768521038944922 0.236157638588696 0.974673829623945 0.833333333333333 11.4 11 4 phenotypic reversion 0.0768521038944922 0.236157638588696 0.974673829623945 0.833333333333333 11.4 11 4 calcified joint 0.0768521038944922 0.236157638588696 0.974673829623945 0.833333333333333 11.4 11 4 extremity edema 0.0768521038944922 0.236157638588696 0.974673829623945 0.833333333333333 11.4 11 4 esophageal atresia 0.0768521038944922 0.236157638588696 0.974673829623945 0.833333333333333 11.4 11 4 decreased liver function 0.0768521038944922 0.236157638588696 0.974673829623945 0.833333333333333 11.4 11 4 ureter obstruction 0.0768521038944922 0.236157638588696 0.974673829623945 0.833333333333333 11.4 11 4 matted coat 0.0768521038944922 0.236157638588696 0.974673829623945 0.833333333333333 11.4 11 4 abnormal ST segment 0.0768521038944922 0.236157638588696 0.974673829623945 0.833333333333333 11.4 11 4 abnormal cholesterol level 0.0768521038944922 0.236157638588696 0.974673829623945 0.833333333333333 11.4 11 4 bowed humerus 0.0768521038944922 0.236157638588696 0.974673829623945 0.833333333333333 11.4 11 4 absent parietal bone 0.0768521038944922 0.236157638588696 0.974673829623945 0.833333333333333 11.4 11 4 increased triiodothyronine level 0.0768521038944922 0.236157638588696 0.974673829623945 0.833333333333333 11.4 11 4 abnormal eyelid development 0.0768521038944922 0.236157638588696 0.974673829623945 0.833333333333333 11.4 11 4 delayed chorioallantoic fusion 0.0768521038944922 0.236157638588696 0.974673829623945 0.833333333333333 11.4 11 4 increased urine uric acid level 0.0768521038944922 0.236157638588696 0.974673829623945 0.833333333333333 11.4 11 4 absent sperm mitochondrial sheath 0.0768521038944922 0.236157638588696 0.974673829623945 0.833333333333333 11.4 11 4 abnormal neural crest cell morphology 0.0768521038944922 0.236157638588696 0.974673829623945 0.833333333333333 11.4 11 4 abnormal aorta tunica adventitia morphology 0.0768521038944922 0.236157638588696 0.974673829623945 0.833333333333333 11.4 11 4 ectopic hippocampus pyramidal cells 0.0768521038944922 0.236157638588696 0.974673829623945 0.833333333333333 11.4 11 4 abnormal orbit morphology 0.0768521038944922 0.236157638588696 0.974673829623945 0.833333333333333 11.4 11 4 increased erythrocyte clearance 0.0768521038944922 0.236157638588696 0.974673829623945 0.833333333333333 11.4 11 4 enlarged lymphatic vessel 0.0768521038944922 0.236157638588696 0.974673829623945 0.833333333333333 11.4 11 4 kidney microaneurysm 0.0768521038944922 0.236157638588696 0.974673829623945 0.833333333333333 11.4 11 4 myocardium hypoplasia 0.0768521038944922 0.236157638588696 0.974673829623945 0.833333333333333 11.4 11 4 common truncal valve 0.0768521038944922 0.236157638588696 0.974673829623945 0.833333333333333 11.4 11 4 abnormal intestinal enteroendocrine cell morphology 0.0768521038944922 0.236157638588696 0.974673829623945 0.833333333333333 11.4 11 4 ectopic ureteric bud 0.0768521038944922 0.236157638588696 0.974673829623945 0.833333333333333 11.4 11 4 decreased macrophage nitric oxide production 0.0768521038944922 0.236157638588696 0.974673829623945 0.833333333333333 11.4 11 4 abnormal ureteric bud tip morphology 0.0768521038944922 0.236157638588696 0.974673829623945 0.833333333333333 11.4 11 4 abnormal kidney collecting duct epithelium morphology 0.0768521038944922 0.236157638588696 0.974673829623945 0.833333333333333 11.4 11 4 abnormal endocrine pancreas development 0.0768521038944922 0.236157638588696 0.974673829623945 0.833333333333333 11.4 11 4 absent midbrain 0.0768521038944922 0.236157638588696 0.974673829623945 0.833333333333333 11.4 11 4 absent thymus corticomedullary boundary 0.0768521038944922 0.236157638588696 0.974673829623945 0.833333333333333 11.4 11 4 abnormal vertebral artery origin 0.0768521038944922 0.236157638588696 0.974673829623945 0.833333333333333 11.4 11 4 abnormal platelet alpha-granule morphology 0.0768521038944922 0.236157638588696 0.974673829623945 0.833333333333333 11.4 11 4 ectopic bone 0.0768521038944922 0.236157638588696 0.974673829623945 0.833333333333333 11.4 11 4 decreased tear production 0.0768521038944922 0.236157638588696 0.974673829623945 0.833333333333333 11.4 11 4 decreased capillary density 0.0768521038944922 0.236157638588696 0.974673829623945 0.833333333333333 11.4 11 4 increased cardiac cell glucose uptake 0.0768521038944922 0.236157638588696 0.974673829623945 0.833333333333333 11.4 11 4 embryonic lethality between implantation and somite formation, complete penetrance 1.35833232368066e-33 5.63141942525942e-31 0.973878177518129 0.83265306122449 11.4 11 4 embryonic lethality before implantation, complete penetrance 9.12036350449632e-18 1.106678254509e-15 0.973114351496546 0.832 11.4 11 4 pale yolk sac 3.24427076271095e-12 1.81351090387494e-10 0.972325217986297 0.831325301204819 11.4 11 4 atrioventricular septal defect 3.16374768453937e-08 8.73593207624647e-07 0.970995815172534 0.830188679245283 11.4 11 4 abnormal liver physiology 2.44196013721591e-14 1.78658112980134e-12 0.970775134305449 0.83 11.4 11 4 abnormal cell differentiation 1.28633941737809e-06 2.40584157949474e-05 0.969919323137974 0.829268292682927 11.4 11 4 abnormal erythropoiesis 7.12148954100454e-15 5.62371594706311e-13 0.969104264883237 0.828571428571429 11.4 11 4 embryonic lethality between somite formation and embryo turning, complete penetrance 2.29605835000771e-10 9.36302482892489e-09 0.969104264883237 0.828571428571429 11.4 11 4 abnormal liver development 8.3044128883283e-06 0.000126343896389704 0.969104264883237 0.828571428571429 11.4 11 4 decreased triglyceride level 8.3044128883283e-06 0.000126343896389704 0.969104264883237 0.828571428571429 11.4 11 4 decreased bone mineralization 8.3044128883283e-06 0.000126343896389704 0.969104264883237 0.828571428571429 11.4 11 4 abnormal spinal nerve morphology 5.42778297507376e-05 0.00067847287188422 0.96795194114378 0.827586206896552 11.4 11 4 abnormal outer ear morphology 5.42778297507376e-05 0.00067847287188422 0.96795194114378 0.827586206896552 11.4 11 4 liver hypoplasia 5.73064181426891e-08 1.49266717413549e-06 0.967176338626837 0.826923076923077 11.4 11 4 abnormal placenta vasculature 5.73064181426891e-08 1.49266717413549e-06 0.967176338626837 0.826923076923077 11.4 11 4 kinked neural tube 5.73064181426891e-08 1.49266717413549e-06 0.967176338626837 0.826923076923077 11.4 11 4 abnormal postnatal growth 0.000361149238432878 0.00348201058372784 0.966198405018519 0.826086956521739 11.4 11 4 abnormal sacral vertebrae morphology 0.000361149238432878 0.00348201058372784 0.966198405018519 0.826086956521739 11.4 11 4 abnormal Wolffian duct morphology 0.000361149238432878 0.00348201058372784 0.966198405018519 0.826086956521739 11.4 11 4 abnormal chondrocyte physiology 0.000361149238432878 0.00348201058372784 0.966198405018519 0.826086956521739 11.4 11 4 abnormal hematopoietic stem cell physiology 0.000361149238432878 0.00348201058372784 0.966198405018519 0.826086956521739 11.4 11 4 abnormal vertebral artery topology 0.000361149238432878 0.00348201058372784 0.966198405018519 0.826086956521739 11.4 11 4 increased hepatocellular carcinoma incidence 1.6368500996775e-08 4.7344937476137e-07 0.964414105101588 0.824561403508772 11.4 11 4 abnormal extraembryonic tissue morphology 4.17233890817323e-14 2.84347754358381e-12 0.963207078687192 0.823529411764706 11.4 11 4 small lung 1.03412304928221e-07 2.48539235274346e-06 0.963207078687192 0.823529411764706 11.4 11 4 abnormal bone marrow cavity morphology 0.00247083842703925 0.0169550636889935 0.963207078687192 0.823529411764706 11.4 11 4 abnormal vagus nerve morphology 0.00247083842703925 0.0169550636889935 0.963207078687192 0.823529411764706 11.4 11 4 abnormal embryonic-extraembryonic boundary morphology 0.00247083842703925 0.0169550636889935 0.963207078687192 0.823529411764706 11.4 11 4 increased brain size 0.00247083842703925 0.0169550636889935 0.963207078687192 0.823529411764706 11.4 11 4 coloboma 0.00247083842703925 0.0169550636889935 0.963207078687192 0.823529411764706 11.4 11 4 increased hepatoma incidence 0.00247083842703925 0.0169550636889935 0.963207078687192 0.823529411764706 11.4 11 4 abnormal ductus venosus valve morphology 0.00247083842703925 0.0169550636889935 0.963207078687192 0.823529411764706 11.4 11 4 abnormal placenta morphology 3.44871091613731e-11 1.58864229701696e-09 0.962336186210984 0.822784810126582 11.4 11 4 abnormal placenta labyrinth morphology 3.44871091613731e-11 1.58864229701696e-09 0.962336186210984 0.822784810126582 11.4 11 4 lymphoid hyperplasia 9.82786077758093e-05 0.00112918261820936 0.960749917772174 0.821428571428571 11.4 11 4 hypoxia 9.82786077758093e-05 0.00112918261820936 0.960749917772174 0.821428571428571 11.4 11 4 increased triglyceride level 9.82786077758093e-05 0.00112918261820936 0.960749917772174 0.821428571428571 11.4 11 4 abnormal mitotic spindle morphology 9.82786077758093e-05 0.00112918261820936 0.960749917772174 0.821428571428571 11.4 11 4 short stride length 1.85883782751836e-07 4.12844562138564e-06 0.959079048349962 0.82 11.4 11 4 decreased circulating alkaline phosphatase level 1.85883782751836e-07 4.12844562138564e-06 0.959079048349962 0.82 11.4 11 4 abnormal tail movements 0.000653831209013312 0.00577763812582811 0.956952487267146 0.818181818181818 11.4 11 4 aphakia 0.000653831209013312 0.00577763812582811 0.956952487267146 0.818181818181818 11.4 11 4 abnormal lysosome physiology 0.000653831209013312 0.00577763812582811 0.956952487267146 0.818181818181818 11.4 11 4 abnormal basement membrane morphology 0.000653831209013312 0.00577763812582811 0.956952487267146 0.818181818181818 11.4 11 4 abnormal blood-brain barrier function 0.000653831209013312 0.00577763812582811 0.956952487267146 0.818181818181818 11.4 11 4 increased mammary gland tumor incidence 0.000653831209013312 0.00577763812582811 0.956952487267146 0.818181818181818 11.4 11 4 increased adenoma incidence 0.000653831209013312 0.00577763812582811 0.956952487267146 0.818181818181818 11.4 11 4 absent semicircular canals 0.0177561146421186 0.0827897566490534 0.956952487267146 0.818181818181818 11.4 11 4 abnormal sphenoid bone morphology 0.0177561146421186 0.0827897566490534 0.956952487267146 0.818181818181818 11.4 11 4 abnormal thrombopoiesis 0.0177561146421186 0.0827897566490534 0.956952487267146 0.818181818181818 11.4 11 4 decreased atrioventricular cushion size 0.0177561146421186 0.0827897566490534 0.956952487267146 0.818181818181818 11.4 11 4 delayed hepatic development 0.0177561146421186 0.0827897566490534 0.956952487267146 0.818181818181818 11.4 11 4 failure of somite differentiation 0.0177561146421186 0.0827897566490534 0.956952487267146 0.818181818181818 11.4 11 4 abnormal proximal-distal axis patterning 0.0177561146421186 0.0827897566490534 0.956952487267146 0.818181818181818 11.4 11 4 abnormal hypothalamus secretion 0.0177561146421186 0.0827897566490534 0.956952487267146 0.818181818181818 11.4 11 4 abnormal bronchiole morphology 0.0177561146421186 0.0827897566490534 0.956952487267146 0.818181818181818 11.4 11 4 loss of cortex neurons 0.0177561146421186 0.0827897566490534 0.956952487267146 0.818181818181818 11.4 11 4 abnormal radial glial cell morphology 0.0177561146421186 0.0827897566490534 0.956952487267146 0.818181818181818 11.4 11 4 increased glycogen level 0.0177561146421186 0.0827897566490534 0.956952487267146 0.818181818181818 11.4 11 4 palatal shelf hypoplasia 0.0177561146421186 0.0827897566490534 0.956952487267146 0.818181818181818 11.4 11 4 abnormal palatal shelf elevation 0.0177561146421186 0.0827897566490534 0.956952487267146 0.818181818181818 11.4 11 4 common atrioventricular valve 0.0177561146421186 0.0827897566490534 0.956952487267146 0.818181818181818 11.4 11 4 abnormal brain ependyma motile cilium morphology 0.0177561146421186 0.0827897566490534 0.956952487267146 0.818181818181818 11.4 11 4 hypolactation 0.0177561146421186 0.0827897566490534 0.956952487267146 0.818181818181818 11.4 11 4 reduced sympathetic cervical ganglion size 0.0177561146421186 0.0827897566490534 0.956952487267146 0.818181818181818 11.4 11 4 enlarged pericardium 2.70776920840243e-05 0.000367061357269811 0.956952487267146 0.818181818181818 11.4 11 4 increased cardiomyocyte apoptosis 2.70776920840243e-05 0.000367061357269811 0.956952487267146 0.818181818181818 11.4 11 4 abnormal developmental patterning 3.18495493578014e-11 1.52357219283714e-09 0.955655803680063 0.817073170731707 11.4 11 4 impaired branching involved in ureteric bud morphogenesis 7.52828825330211e-06 0.000117859305808237 0.95415438057923 0.815789473684211 11.4 11 4 thin epidermis 0.000176741522363838 0.00187882280717969 0.953014411187857 0.814814814814815 11.4 11 4 abnormal type II pneumocyte morphology 0.000176741522363838 0.00187882280717969 0.953014411187857 0.814814814814815 11.4 11 4 abnormal fetal cardiomyocyte proliferation 0.000176741522363838 0.00187882280717969 0.953014411187857 0.814814814814815 11.4 11 4 thick interventricular septum 0.000176741522363838 0.00187882280717969 0.953014411187857 0.814814814814815 11.4 11 4 embryonic lethality during organogenesis, complete penetrance 7.10181724976234e-67 8.83288520439191e-64 0.950306983883346 0.8125 11.4 11 4 overriding aortic valve 5.93185780598724e-07 1.17107113431692e-05 0.950306983883346 0.8125 11.4 11 4 scoliosis 4.84646536883786e-05 0.000613515654197668 0.950306983883346 0.8125 11.4 11 4 abnormal bone marrow cell number 0.00447207468378913 0.0275515130565627 0.950306983883346 0.8125 11.4 11 4 increased intestinal adenocarcinoma incidence 0.00447207468378913 0.0275515130565627 0.950306983883346 0.8125 11.4 11 4 blepharitis 0.00447207468378913 0.0275515130565627 0.950306983883346 0.8125 11.4 11 4 dystonia 0.00447207468378913 0.0275515130565627 0.950306983883346 0.8125 11.4 11 4 impaired somite development 0.00447207468378913 0.0275515130565627 0.950306983883346 0.8125 11.4 11 4 embryonic lethality between somite formation and embryo turning, incomplete penetrance 0.00447207468378913 0.0275515130565627 0.950306983883346 0.8125 11.4 11 4 embryonic growth arrest 4.82725693028837e-28 1.50097520176154e-25 0.9499877675636 0.812227074235808 11.4 11 4 abnormal chromosome morphology 1.34265763246134e-05 0.000195313500628513 0.948331293688162 0.810810810810811 11.4 11 4 abnormal respiratory electron transport chain 1.34265763246134e-05 0.000195313500628513 0.948331293688162 0.810810810810811 11.4 11 4 abnormal embryonic neuroepithelium morphology 4.75685910538855e-08 1.28616163311457e-06 0.947786275703284 0.810344827586207 11.4 11 4 spina bifida 3.74839318270689e-06 6.17491923310159e-05 0.946826005920403 0.80952380952381 11.4 11 4 abnormal eye pigmentation 0.00117360920376074 0.00925309950667146 0.946826005920403 0.80952380952381 11.4 11 4 absent segment of posterior cerebral artery 0.00117360920376074 0.00925309950667146 0.946826005920403 0.80952380952381 11.4 11 4 increased muscle cell glucose uptake 0.00117360920376074 0.00925309950667146 0.946826005920403 0.80952380952381 11.4 11 4 embryonic lethality, complete penetrance 9.60167005813433e-38 4.77683085392183e-35 0.945953033390512 0.808777429467085 11.4 11 4 small liver 3.15853601858021e-10 1.25709733539492e-08 0.944683865635516 0.807692307692308 11.4 11 4 ventricular hypoplasia 0.000315526553725871 0.00309614320470652 0.944683865635516 0.807692307692308 11.4 11 4 thick skin 0.000315526553725871 0.00309614320470652 0.944683865635516 0.807692307692308 11.4 11 4 decreased circulating glycerol level 0.000315526553725871 0.00309614320470652 0.944683865635516 0.807692307692308 11.4 11 4 decreased birth body size 2.92434121387072e-14 2.07837107700097e-12 0.943894656056873 0.807017543859649 11.4 11 4 abnormal facial morphology 8.41461437141695e-08 2.08272171630842e-06 0.943894656056873 0.807017543859649 11.4 11 4 osteopetrosis 8.6190494982307e-05 0.00102338356214076 0.943232738345753 0.806451612903226 11.4 11 4 decreased thymus weight 8.6190494982307e-05 0.00102338356214076 0.943232738345753 0.806451612903226 11.4 11 4 preaxial polydactyly 8.6190494982307e-05 0.00102338356214076 0.943232738345753 0.806451612903226 11.4 11 4 liver fibrosis 6.63286045375799e-06 0.000104425572017234 0.941392284222152 0.804878048780488 11.4 11 4 abnormal allantois morphology 1.85961036220512e-06 3.4013093941068e-05 0.940772131202242 0.804347826086957 11.4 11 4 double outlet right ventricle 3.13555092934849e-13 1.92584763870478e-11 0.940059245020478 0.803738317757009 11.4 11 4 decreased body length 1.6688289982247e-31 5.53494951077858e-29 0.939101792046429 0.802919708029197 11.4 11 4 abnormal embryonic tissue morphology 1.51542949762677e-17 1.713468579703e-15 0.938869484862249 0.802721088435374 11.4 11 4 prenatal lethality, complete penetrance 8.4557954357881e-32 3.00482730664613e-29 0.938211211537294 0.802158273381295 11.4 11 4 extramedullary hematopoiesis 5.496456576143e-13 3.29456282726644e-11 0.937893685109834 0.80188679245283 11.4 11 4 increased erythrocyte cell number 7.38183909456792e-08 1.88331535874233e-06 0.935686876438987 0.8 11.4 11 4 absent incisors 0.00800091231707918 0.0442764613764949 0.935686876438987 0.8 11.4 11 4 abnormal seizure response to electrical stimulation 0.00800091231707918 0.0442764613764949 0.935686876438987 0.8 11.4 11 4 placental labyrinth hypoplasia 0.00800091231707918 0.0442764613764949 0.935686876438987 0.8 11.4 11 4 abnormal glial cell morphology 0.00800091231707918 0.0442764613764949 0.935686876438987 0.8 11.4 11 4 abnormal ear development 0.00800091231707918 0.0442764613764949 0.935686876438987 0.8 11.4 11 4 abnormal trophectoderm morphology 0.00800091231707918 0.0442764613764949 0.935686876438987 0.8 11.4 11 4 decreased brown adipose tissue mass 0.00800091231707918 0.0442764613764949 0.935686876438987 0.8 11.4 11 4 trabecula carnea hypoplasia 3.26906333260093e-06 5.45758056365424e-05 0.935686876438987 0.8 11.4 11 4 abnormal metabolism 3.26906333260093e-06 5.45758056365424e-05 0.935686876438987 0.8 11.4 11 4 abnormal embryonic epiblast morphology 4.19720150689845e-05 0.0005354122435082 0.935686876438987 0.8 11.4 11 4 abnormal pericardium morphology 0.00208689061053677 0.0148318296963149 0.935686876438987 0.8 11.4 11 4 abnormal hyoid bone morphology 0.00208689061053677 0.0148318296963149 0.935686876438987 0.8 11.4 11 4 abnormal postnatal subventricular zone morphology 0.00208689061053677 0.0148318296963149 0.935686876438987 0.8 11.4 11 4 kidney atrophy 0.00208689061053677 0.0148318296963149 0.935686876438987 0.8 11.4 11 4 abnormal heart electrocardiography waveform feature 0.00208689061053677 0.0148318296963149 0.935686876438987 0.8 11.4 11 4 abnormal auchene hair morphology 0.032110809020036 0.126585796255688 0.935686876438987 0.8 11.4 11 4 abnormal epidermis suprabasal layer morphology 0.032110809020036 0.126585796255688 0.935686876438987 0.8 11.4 11 4 fused cornea and lens 0.032110809020036 0.126585796255688 0.935686876438987 0.8 11.4 11 4 abnormal immune cell physiology 0.032110809020036 0.126585796255688 0.935686876438987 0.8 11.4 11 4 rhinitis 0.032110809020036 0.126585796255688 0.935686876438987 0.8 11.4 11 4 decreased incidence of induced tumors 0.032110809020036 0.126585796255688 0.935686876438987 0.8 11.4 11 4 abnormal respiratory mechanics 0.032110809020036 0.126585796255688 0.935686876438987 0.8 11.4 11 4 abnormal PNS synaptic transmission 0.032110809020036 0.126585796255688 0.935686876438987 0.8 11.4 11 4 impaired social transmission of food preference 0.032110809020036 0.126585796255688 0.935686876438987 0.8 11.4 11 4 impaired basement membrane formation 0.032110809020036 0.126585796255688 0.935686876438987 0.8 11.4 11 4 acrania 0.032110809020036 0.126585796255688 0.935686876438987 0.8 11.4 11 4 aneurysm 0.032110809020036 0.126585796255688 0.935686876438987 0.8 11.4 11 4 lymphedema 0.032110809020036 0.126585796255688 0.935686876438987 0.8 11.4 11 4 bifid ureter 0.032110809020036 0.126585796255688 0.935686876438987 0.8 11.4 11 4 absent seminal vesicle 0.032110809020036 0.126585796255688 0.935686876438987 0.8 11.4 11 4 abnormal pillar cell morphology 0.032110809020036 0.126585796255688 0.935686876438987 0.8 11.4 11 4 abnormal gas homeostasis 0.032110809020036 0.126585796255688 0.935686876438987 0.8 11.4 11 4 abnormal embryonic erythrocyte morphology 0.032110809020036 0.126585796255688 0.935686876438987 0.8 11.4 11 4 abnormal utricular macula morphology 0.032110809020036 0.126585796255688 0.935686876438987 0.8 11.4 11 4 abnormal gonadal fat pad morphology 0.032110809020036 0.126585796255688 0.935686876438987 0.8 11.4 11 4 vascular smooth muscle hyperplasia 0.032110809020036 0.126585796255688 0.935686876438987 0.8 11.4 11 4 increased platelet aggregation 0.032110809020036 0.126585796255688 0.935686876438987 0.8 11.4 11 4 crystalluria 0.032110809020036 0.126585796255688 0.935686876438987 0.8 11.4 11 4 abnormal spinal cord dorsal column morphology 0.032110809020036 0.126585796255688 0.935686876438987 0.8 11.4 11 4 decreased transitional stage T2 B cell number 0.032110809020036 0.126585796255688 0.935686876438987 0.8 11.4 11 4 increased circulating fructosamine level 0.032110809020036 0.126585796255688 0.935686876438987 0.8 11.4 11 4 acanthocytosis 0.032110809020036 0.126585796255688 0.935686876438987 0.8 11.4 11 4 increased T-helper 17 cell number 0.032110809020036 0.126585796255688 0.935686876438987 0.8 11.4 11 4 aorta stenosis 0.032110809020036 0.126585796255688 0.935686876438987 0.8 11.4 11 4 thin ventricle myocardium compact layer 0.032110809020036 0.126585796255688 0.935686876438987 0.8 11.4 11 4 thick aortic valve cusps 0.032110809020036 0.126585796255688 0.935686876438987 0.8 11.4 11 4 fusion of atlas and odontoid process 0.032110809020036 0.126585796255688 0.935686876438987 0.8 11.4 11 4 increased compact bone area 0.032110809020036 0.126585796255688 0.935686876438987 0.8 11.4 11 4 decreased circulating lactate level 0.032110809020036 0.126585796255688 0.935686876438987 0.8 11.4 11 4 decreased rib number 7.04421906700719e-11 3.02111981537593e-09 0.933058542516405 0.797752808988764 11.4 11 4 abnormal somite development 8.5576035842761e-10 3.08507810375171e-08 0.932725842019876 0.79746835443038 11.4 11 4 perimembraneous ventricular septal defect 1.04605643996264e-08 3.1350185474784e-07 0.932296706596817 0.797101449275362 11.4 11 4 abnormal apoptosis 4.5466856163251e-07 9.08424134185436e-06 0.931354992751769 0.796296296296296 11.4 11 4 abnormal long bone epiphyseal plate proliferative zone 4.5466856163251e-07 9.08424134185436e-06 0.931354992751769 0.796296296296296 11.4 11 4 abnormal osteoblast physiology 4.5466856163251e-07 9.08424134185436e-06 0.931354992751769 0.796296296296296 11.4 11 4 embryonic lethality during organogenesis, incomplete penetrance 1.50320246762179e-25 3.7392161382092e-23 0.930601621675732 0.795652173913043 11.4 11 4 abnormal iris morphology 2.04312938395087e-05 0.000280789190197667 0.929688883641301 0.794871794871795 11.4 11 4 increased hepatocyte apoptosis 2.04312938395087e-05 0.000280789190197667 0.929688883641301 0.794871794871795 11.4 11 4 pericardial edema 1.82014631142537e-08 5.20415396513862e-07 0.928806825876936 0.794117647058823 11.4 11 4 enlarged liver sinusoidal spaces 7.35167615852027e-05 0.000889892673689498 0.928806825876936 0.794117647058823 11.4 11 4 cleft palate 5.08982776716231e-15 4.15113002321844e-13 0.928544228527239 0.793893129770992 11.4 11 4 gliosis 6.38242992555796e-08 1.63673138554901e-06 0.928260790118043 0.793650793650794 11.4 11 4 short limbs 2.1278018800638e-10 8.82151196109784e-09 0.927620610262789 0.793103448275862 11.4 11 4 lordosis 0.000266948256871916 0.00268296480391471 0.927620610262789 0.793103448275862 11.4 11 4 decreased trophoblast giant cell number 0.000266948256871916 0.00268296480391471 0.927620610262789 0.793103448275862 11.4 11 4 abnormal osteoblast morphology 0.000981399150707322 0.00787493673349827 0.925940138142748 0.791666666666667 11.4 11 4 hydrops fetalis 9.02102817369595e-09 2.77034661507021e-07 0.925940138142747 0.791666666666667 11.4 11 4 increased grip strength 1.05909470106785e-10 4.50341550240389e-09 0.925404603071526 0.791208791208791 11.4 11 4 abnormal left-right axis patterning 9.94724802817988e-06 0.000146847355905623 0.924806796480394 0.790697674418605 11.4 11 4 prenatal lethality 1.10620401325696e-07 2.60327763361892e-06 0.924368083578838 0.790322580645161 11.4 11 4 decreased heart weight 1.2817115770155e-09 4.52235113166818e-08 0.924135186606407 0.790123456790123 11.4 11 4 enlarged liver 1.51811504484407e-11 7.47784390900916e-10 0.9239907904835 0.79 11.4 11 4 incomplete somite formation 3.55451565920302e-05 0.000464139511930054 0.923375207012158 0.789473684210526 11.4 11 4 kyphoscoliosis 0.003672647876542 0.0233649912861847 0.923375207012158 0.789473684210526 11.4 11 4 small superior vagus ganglion 0.003672647876542 0.0233649912861847 0.923375207012158 0.789473684210526 11.4 11 4 abnormal stationary movement 0.003672647876542 0.0233649912861847 0.923375207012158 0.789473684210526 11.4 11 4 stereotypic behavior 0.003672647876542 0.0233649912861847 0.923375207012158 0.789473684210526 11.4 11 4 delayed sexual maturation 0.003672647876542 0.0233649912861847 0.923375207012158 0.789473684210526 11.4 11 4 decreased germ cell number 0.003672647876542 0.0233649912861847 0.923375207012158 0.789473684210526 11.4 11 4 absent amnion 0.003672647876542 0.0233649912861847 0.923375207012158 0.789473684210526 11.4 11 4 decreased eye pigmentation 0.003672647876542 0.0233649912861847 0.923375207012158 0.789473684210526 11.4 11 4 Leydig cell hypoplasia 0.003672647876542 0.0233649912861847 0.923375207012158 0.789473684210526 11.4 11 4 increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 0.003672647876542 0.0233649912861847 0.923375207012158 0.789473684210526 11.4 11 4 decreased susceptibility to weight gain 0.003672647876542 0.0233649912861847 0.923375207012158 0.789473684210526 11.4 11 4 incomplete embryo turning 3.88720956605724e-07 7.95838172474681e-06 0.923375207012158 0.789473684210526 11.4 11 4 decreased brain weight 3.88720956605724e-07 7.95838172474681e-06 0.923375207012158 0.789473684210526 11.4 11 4 decreased birth weight 5.26644607452932e-11 2.31863444431711e-09 0.923375207012158 0.789473684210526 11.4 11 4 corneal opacity 1.55908456105292e-08 4.56583296470985e-07 0.922508188038438 0.788732394366197 11.4 11 4 abnormal lung development 6.35382216486638e-10 2.35897502016494e-08 0.921926775314884 0.788235294117647 11.4 11 4 decreased brown adipose tissue amount 0.000127901939647409 0.00140777024280057 0.921509802553548 0.787878787878788 11.4 11 4 abnormal liver morphology 2.80204018037414e-19 4.35629684292542e-17 0.921311798728332 0.787709497206704 11.4 11 4 increased respiratory quotient 4.84509785130138e-06 7.75059865280527e-05 0.92075570287879 0.787234042553192 11.4 11 4 anophthalmia 3.14761182495159e-10 1.25709733539492e-08 0.919916872903498 0.786516853932584 11.4 11 4 abnormal craniofacial morphology 1.29911741125839e-11 6.46310912101048e-10 0.91978928387813 0.786407766990291 11.4 11 4 increased blood urea nitrogen level 9.42256235757777e-16 8.37093709445525e-14 0.919554344086591 0.786206896551724 11.4 11 4 abnormal brainstem morphology 0.00046443887585328 0.00428679667415597 0.918978182216862 0.785714285714286 11.4 11 4 prolonged QRS complex duration 0.00046443887585328 0.00428679667415597 0.918978182216862 0.785714285714286 11.4 11 4 megacephaly 0.0141274713088094 0.0683698149429249 0.918978182216862 0.785714285714286 11.4 11 4 abnormal kidney blood vessel morphology 0.0141274713088094 0.0683698149429249 0.918978182216862 0.785714285714286 11.4 11 4 abnormal fluid regulation 0.0141274713088094 0.0683698149429249 0.918978182216862 0.785714285714286 11.4 11 4 abnormal uterus development 0.0141274713088094 0.0683698149429249 0.918978182216862 0.785714285714286 11.4 11 4 abnormal viscerocranium morphology 0.0141274713088094 0.0683698149429249 0.918978182216862 0.785714285714286 11.4 11 4 spina bifida occulta 0.0141274713088094 0.0683698149429249 0.918978182216862 0.785714285714286 11.4 11 4 decreased tongue size 0.0141274713088094 0.0683698149429249 0.918978182216862 0.785714285714286 11.4 11 4 increased stomach tumor incidence 0.0141274713088094 0.0683698149429249 0.918978182216862 0.785714285714286 11.4 11 4 abnormal renal tubule epithelial cell primary cilium morphology 0.0141274713088094 0.0683698149429249 0.918978182216862 0.785714285714286 11.4 11 4 abnormal vitelline vein topology 0.0141274713088094 0.0683698149429249 0.918978182216862 0.785714285714286 11.4 11 4 abnormal nervous system morphology 3.79938783796412e-09 1.2435496377547e-07 0.917920669924323 0.784810126582278 11.4 11 4 abnormal cervical vertebrae morphology 2.36131893994309e-06 4.13646539655523e-05 0.917340074940183 0.784313725490196 11.4 11 4 abnormal trophoblast layer morphology 2.36131893994309e-06 4.13646539655523e-05 0.917340074940183 0.784313725490196 11.4 11 4 abnormal eye morphology 5.56849820044632e-15 4.46827073342265e-13 0.917175085718072 0.784172661870504 11.4 11 4 abnormal neural tube morphology 3.3722475995125e-17 3.49519412657806e-15 0.916915380461044 0.783950617283951 11.4 11 4 abnormal angiogenesis 1.32214649588928e-08 3.91528501014833e-07 0.916720250565224 0.783783783783784 11.4 11 4 increased erythroid progenitor cell number 6.14519706683032e-05 0.000753013679987213 0.916720250565224 0.783783783783784 11.4 11 4 decreased width of hypertrophic chondrocyte zone 6.14519706683032e-05 0.000753013679987213 0.916720250565224 0.783783783783784 11.4 11 4 abnormal incisor morphology 3.28287883707374e-07 6.94992434657101e-06 0.916193399846508 0.783333333333333 11.4 11 4 hemorrhage 3.76617653875752e-24 8.14640360013855e-22 0.915778645025392 0.782978723404255 11.4 11 4 abnormal cell death 8.34309402602592e-06 0.000126545404815485 0.915345857385965 0.782608695652174 11.4 11 4 abnormal pulmonary artery morphology 0.00170748630310288 0.0126787229222937 0.915345857385965 0.782608695652174 11.4 11 4 bidirectional circling 0.00170748630310288 0.0126787229222937 0.915345857385965 0.782608695652174 11.4 11 4 increased rib number 6.50946532832232e-09 2.06271273938876e-07 0.914693901647087 0.782051282051282 11.4 11 4 absent gastric milk in neonates 6.50946532832232e-09 2.06271273938876e-07 0.914693901647087 0.782051282051282 11.4 11 4 abnormal embryo turning 1.15155574907806e-06 2.17832313751459e-05 0.914421265610828 0.781818181818182 11.4 11 4 decreased circulating LDL cholesterol level 1.607602666916e-07 3.65197409493475e-06 0.913756715272448 0.78125 11.4 11 4 bradykinesia 0.000220925642460621 0.00226619602317854 0.913756715272448 0.78125 11.4 11 4 decreased hemoglobin content 8.06383409489928e-15 6.26837103470686e-13 0.912460606456459 0.780141843971631 11.4 11 4 increased B cell derived lymphoma incidence 4.04994787171288e-06 6.58447407247437e-05 0.912294704528012 0.78 11.4 11 4 increased circulating chloride level 4.04994787171288e-06 6.58447407247437e-05 0.912294704528012 0.78 11.4 11 4 abnormal embryo development 2.77183222311482e-14 1.99853120434728e-12 0.911606699471807 0.779411764705882 11.4 11 4 decreased mean corpuscular hemoglobin 7.87464878705074e-08 1.98864861500393e-06 0.911606699471807 0.779411764705882 11.4 11 4 increased circulating alkaline phosphatase level 1.41546964509412e-16 1.3542233623737e-14 0.909695574315682 0.777777777777778 11.4 11 4 decreased circulating serum albumin level 1.10835552841118e-10 4.67293962190306e-09 0.909695574315682 0.777777777777778 11.4 11 4 oxidative stress 7.76476058090946e-10 2.81968495547625e-08 0.909695574315682 0.777777777777778 11.4 11 4 increased cell proliferation 1.9683000249377e-06 3.52240741872843e-05 0.909695574315682 0.777777777777778 11.4 11 4 abnormal maxilla morphology 1.9683000249377e-06 3.52240741872843e-05 0.909695574315682 0.777777777777778 11.4 11 4 neurodegeneration 1.9683000249377e-06 3.52240741872843e-05 0.909695574315682 0.777777777777778 11.4 11 4 abnormal heart valve morphology 0.000801274163492983 0.00668848819358656 0.909695574315682 0.777777777777778 11.4 11 4 abnormal atrioventricular cushion morphology 0.000801274163492983 0.00668848819358656 0.909695574315682 0.777777777777778 11.4 11 4 abnormal trigeminal nerve morphology 0.000801274163492983 0.00668848819358656 0.909695574315682 0.777777777777778 11.4 11 4 increased brain weight 0.000801274163492983 0.00668848819358656 0.909695574315682 0.777777777777778 11.4 11 4 abnormal pharyngeal arch morphology 0.000105537509008787 0.001199173317074 0.909695574315682 0.777777777777778 11.4 11 4 narrow eye opening 0.000105537509008787 0.001199173317074 0.909695574315682 0.777777777777778 11.4 11 4 abnormal mitral valve morphology 0.00638972198107277 0.0364969768723731 0.909695574315682 0.777777777777778 11.4 11 4 underdeveloped hair follicles 0.00638972198107277 0.0364969768723731 0.909695574315682 0.777777777777778 11.4 11 4 cortical renal glomerulopathies 0.00638972198107277 0.0364969768723731 0.909695574315682 0.777777777777778 11.4 11 4 delayed kidney development 0.00638972198107277 0.0364969768723731 0.909695574315682 0.777777777777778 11.4 11 4 abnormal radius morphology 0.00638972198107277 0.0364969768723731 0.909695574315682 0.777777777777778 11.4 11 4 abnormal Peyer's patch follicle morphology 0.00638972198107277 0.0364969768723731 0.909695574315682 0.777777777777778 11.4 11 4 absent allantois 0.00638972198107277 0.0364969768723731 0.909695574315682 0.777777777777778 11.4 11 4 long tibia 0.00638972198107277 0.0364969768723731 0.909695574315682 0.777777777777778 11.4 11 4 abnormal eye anterior chamber morphology 0.00638972198107277 0.0364969768723731 0.909695574315682 0.777777777777778 11.4 11 4 darkened coat color 0.00638972198107277 0.0364969768723731 0.909695574315682 0.777777777777778 11.4 11 4 abnormal glycogen homeostasis 0.00638972198107277 0.0364969768723731 0.909695574315682 0.777777777777778 11.4 11 4 small thoracic cage 0.00638972198107277 0.0364969768723731 0.909695574315682 0.777777777777778 11.4 11 4 increased effector memory CD4-positive, alpha-beta T cell number 0.00638972198107277 0.0364969768723731 0.909695574315682 0.777777777777778 11.4 11 4 increased effector memory CD8-positive, alpha-beta T cell number 0.00638972198107277 0.0364969768723731 0.909695574315682 0.777777777777778 11.4 11 4 increased adipocyte glucose uptake 0.00638972198107277 0.0364969768723731 0.909695574315682 0.777777777777778 11.4 11 4 abnormal head movements 0.0570298751219076 0.190290830805829 0.909695574315682 0.777777777777778 11.4 11 4 abnormal urinary bladder urothelium morphology 0.0570298751219076 0.190290830805829 0.909695574315682 0.777777777777778 11.4 11 4 abnormal cholinergic neuron morphology 0.0570298751219076 0.190290830805829 0.909695574315682 0.777777777777778 11.4 11 4 abnormal kindling response 0.0570298751219076 0.190290830805829 0.909695574315682 0.777777777777778 11.4 11 4 abnormal ion homeostasis 0.0570298751219076 0.190290830805829 0.909695574315682 0.777777777777778 11.4 11 4 abnormal lung volume 0.0570298751219076 0.190290830805829 0.909695574315682 0.777777777777778 11.4 11 4 abnormal NMDA-mediated synaptic currents 0.0570298751219076 0.190290830805829 0.909695574315682 0.777777777777778 11.4 11 4 yellow coat color 0.0570298751219076 0.190290830805829 0.909695574315682 0.777777777777778 11.4 11 4 premature neuronal precursor differentiation 0.0570298751219076 0.190290830805829 0.909695574315682 0.777777777777778 11.4 11 4 decreased fear-related response 0.0570298751219076 0.190290830805829 0.909695574315682 0.777777777777778 11.4 11 4 abnormal thymus physiology 0.0570298751219076 0.190290830805829 0.909695574315682 0.777777777777778 11.4 11 4 abnormal CNS synapse formation 0.0570298751219076 0.190290830805829 0.909695574315682 0.777777777777778 11.4 11 4 hemothorax 0.0570298751219076 0.190290830805829 0.909695574315682 0.777777777777778 11.4 11 4 abnormal inguinal fat pad morphology 0.0570298751219076 0.190290830805829 0.909695574315682 0.777777777777778 11.4 11 4 decreased susceptibility to atherosclerosis 0.0570298751219076 0.190290830805829 0.909695574315682 0.777777777777778 11.4 11 4 abnormal cerebellar layer morphology 0.0570298751219076 0.190290830805829 0.909695574315682 0.777777777777778 11.4 11 4 prolonged RR interval 0.0570298751219076 0.190290830805829 0.909695574315682 0.777777777777778 11.4 11 4 decreased effector memory CD4-positive, alpha-beta T cell number 0.0570298751219076 0.190290830805829 0.909695574315682 0.777777777777778 11.4 11 4 trigeminal neuroma 0.0570298751219076 0.190290830805829 0.909695574315682 0.777777777777778 11.4 11 4 decreased fatty acid oxidation 0.0570298751219076 0.190290830805829 0.909695574315682 0.777777777777778 11.4 11 4 cerebellum atrophy 0.0570298751219076 0.190290830805829 0.909695574315682 0.777777777777778 11.4 11 4 abnormal enzyme/coenzyme activity 4.8536331806634e-16 4.39033183160008e-14 0.908867825840417 0.777070063694268 11.4 11 4 reduced fertility 2.33166460408422e-14 1.73134797094314e-12 0.908760635390383 0.776978417266187 11.4 11 4 pericardial effusion 4.66415476322105e-07 9.28166797880988e-06 0.905503428811923 0.774193548387097 11.4 11 4 abnormal nose morphology 0.000378694873247905 0.00363007128017018 0.905503428811923 0.774193548387097 11.4 11 4 lethality throughout fetal growth and development, complete penetrance 1.0283726106389e-18 1.38274425349419e-16 0.904907702871915 0.773684210526316 11.4 11 4 enlarged kidney 3.34795803757394e-06 5.57059907589644e-05 0.904791555047134 0.773584905660377 11.4 11 4 abnormal behavior 1.17151633395889e-26 3.42840809496792e-24 0.904553410226539 0.773381294964029 11.4 11 4 small kidney 2.23126352487976e-09 7.655542093984e-08 0.903788460196749 0.772727272727273 11.4 11 4 abnormal germ layer development 0.00294085438590199 0.0192763512119399 0.903788460196749 0.772727272727273 11.4 11 4 intestinal inflammation 0.00294085438590199 0.0192763512119399 0.903788460196749 0.772727272727273 11.4 11 4 increased skin papilloma incidence 0.00294085438590199 0.0192763512119399 0.903788460196749 0.772727272727273 11.4 11 4 abnormal vascular branching morphogenesis 0.00294085438590199 0.0192763512119399 0.903788460196749 0.772727272727273 11.4 11 4 prolonged PR interval 0.00294085438590199 0.0192763512119399 0.903788460196749 0.772727272727273 11.4 11 4 abnormal tail morphology 2.27370942378454e-07 4.96127385233689e-06 0.903788460196749 0.772727272727273 11.4 11 4 abnormal visceral yolk sac morphology 1.56936168234248e-08 4.56583296470985e-07 0.903115497828769 0.772151898734177 11.4 11 4 pallor 4.09676204190936e-17 4.15946758336715e-15 0.902269487994737 0.771428571428571 11.4 11 4 domed cranium 1.10933639864766e-07 2.60327763361892e-06 0.902269487994737 0.771428571428571 11.4 11 4 increased circulating serum albumin level 0.000179980281077441 0.00190917249117328 0.902269487994737 0.771428571428571 11.4 11 4 short tail 7.6845058791037e-09 2.38940104678381e-07 0.901866868856855 0.771084337349398 11.4 11 4 decreased erythrocyte cell number 1.9577582791294e-15 1.65082159977437e-13 0.901418089563037 0.770700636942675 11.4 11 4 increased bone mineral content 3.78514383340139e-11 1.72762298818091e-09 0.901349743358657 0.770642201834862 11.4 11 4 abnormal brain morphology 9.65876777000488e-16 8.43024029048671e-14 0.900816558062379 0.770186335403727 11.4 11 4 limb grasping 1.67923950152211e-17 1.85649256001611e-15 0.899698919652872 0.769230769230769 11.4 11 4 distended pericardium 5.66585553715782e-06 8.97695264247138e-05 0.899698919652872 0.769230769230769 11.4 11 4 failure of heart looping 8.59246991004364e-05 0.00102338356214076 0.899698919652872 0.769230769230769 11.4 11 4 abnormal ureter morphology 0.0013699497399378 0.0105287711704124 0.899698919652872 0.769230769230769 11.4 11 4 heart inflammation 0.0013699497399378 0.0105287711704124 0.899698919652872 0.769230769230769 11.4 11 4 decreased bone resorption 0.0013699497399378 0.0105287711704124 0.899698919652872 0.769230769230769 11.4 11 4 abnormal nerve conduction 0.0013699497399378 0.0105287711704124 0.899698919652872 0.769230769230769 11.4 11 4 absent common myeloid progenitor cells 0.0245737411224227 0.102304905509668 0.899698919652872 0.769230769230769 11.4 11 4 abnormal renal/urinary system morphology 0.0245737411224227 0.102304905509668 0.899698919652872 0.769230769230769 11.4 11 4 pup cannibalization 0.0245737411224227 0.102304905509668 0.899698919652872 0.769230769230769 11.4 11 4 abnormal grip strength 0.0245737411224227 0.102304905509668 0.899698919652872 0.769230769230769 11.4 11 4 abnormal lung interstitium morphology 0.0245737411224227 0.102304905509668 0.899698919652872 0.769230769230769 11.4 11 4 increased synaptic depression 0.0245737411224227 0.102304905509668 0.899698919652872 0.769230769230769 11.4 11 4 tracheoesophageal fistula 0.0245737411224227 0.102304905509668 0.899698919652872 0.769230769230769 11.4 11 4 abnormal vertebral arch development 0.0245737411224227 0.102304905509668 0.899698919652872 0.769230769230769 11.4 11 4 small pituitary gland 0.0245737411224227 0.102304905509668 0.899698919652872 0.769230769230769 11.4 11 4 orthokeratosis 0.0245737411224227 0.102304905509668 0.899698919652872 0.769230769230769 11.4 11 4 empty decidua capsularis 0.0245737411224227 0.102304905509668 0.899698919652872 0.769230769230769 11.4 11 4 cataract 4.5038896955116e-12 2.40933884249142e-10 0.898955366826713 0.768595041322314 11.4 11 4 short snout 6.36654810396272e-11 2.77838393133461e-09 0.898865865097638 0.768518518518518 11.4 11 4 sparse hair 1.29400753657895e-08 3.85490269130557e-07 0.898601725848417 0.768292682926829 11.4 11 4 edema 1.9449799039304e-16 1.7919027818618e-14 0.897606596583912 0.767441860465116 11.4 11 4 abnormal organ of Corti morphology 4.11738154317383e-05 0.000526580287333928 0.897606596583912 0.767441860465116 11.4 11 4 abnormal homeostasis 4.11738154317383e-05 0.000526580287333928 0.897606596583912 0.767441860465116 11.4 11 4 abnormal blood circulation 4.11738154317383e-05 0.000526580287333928 0.897606596583912 0.767441860465116 11.4 11 4 delayed endochondral bone ossification 4.11738154317383e-05 0.000526580287333928 0.897606596583912 0.767441860465116 11.4 11 4 abnormal double-strand DNA break repair 4.11738154317383e-05 0.000526580287333928 0.897606596583912 0.767441860465116 11.4 11 4 abnormal fertility/fecundity 9.1151417793648e-08 2.21295676405643e-06 0.897233991105878 0.767123287671233 11.4 11 4 delayed eyelid opening 0.000643847239943484 0.00576104319913459 0.896699923254029 0.766666666666667 11.4 11 4 abnormal optic cup morphology 0.000643847239943484 0.00576104319913459 0.896699923254029 0.766666666666667 11.4 11 4 abnormal fat pad morphology 0.000643847239943484 0.00576104319913459 0.896699923254029 0.766666666666667 11.4 11 4 decreased leukocyte cell number 2.63948182366786e-13 1.66220532566425e-11 0.896415346953409 0.766423357664234 11.4 11 4 increased tumor incidence 3.71369067488131e-12 2.0302869348939e-10 0.896071101428465 0.766129032258065 11.4 11 4 hepatic necrosis 1.97910815069424e-05 0.000274263594699271 0.895870413611796 0.765957446808511 11.4 11 4 neuron degeneration 1.97910815069424e-05 0.000274263594699271 0.895870413611796 0.765957446808511 11.4 11 4 failure of chorioallantoic fusion 9.53799189996474e-06 0.000141224731256918 0.894406573066679 0.764705882352941 11.4 11 4 abnormal dendritic spine morphology 9.53799189996474e-06 0.000141224731256918 0.894406573066679 0.764705882352941 11.4 11 4 abnormal nervous system development 0.00030465376834958 0.00303737975458749 0.894406573066679 0.764705882352941 11.4 11 4 increased incidence of corneal inflammation 0.0109760925182262 0.0552134077635748 0.894406573066679 0.764705882352941 11.4 11 4 abnormal dorsal-ventral axis patterning 0.0109760925182262 0.0552134077635748 0.894406573066679 0.764705882352941 11.4 11 4 absence seizures 0.0109760925182262 0.0552134077635748 0.894406573066679 0.764705882352941 11.4 11 4 abnormal testis development 0.0109760925182262 0.0552134077635748 0.894406573066679 0.764705882352941 11.4 11 4 increased trabecular bone mass 0.0109760925182262 0.0552134077635748 0.894406573066679 0.764705882352941 11.4 11 4 abnormal cell cytoskeleton morphology 0.0109760925182262 0.0552134077635748 0.894406573066679 0.764705882352941 11.4 11 4 decreased neuron apoptosis 0.000144929482691847 0.00158119336928057 0.892596033445086 0.763157894736842 11.4 11 4 abnormal blood homeostasis 4.29921961493256e-11 1.90969799859728e-09 0.892596033445086 0.763157894736842 11.4 11 4 abnormal rib morphology 7.3678408936359e-13 4.36369148164745e-11 0.892368039566812 0.762962962962963 11.4 11 4 abnormal scapula morphology 0.00500939111222009 0.0304666513243214 0.891130358513321 0.761904761904762 11.4 11 4 abnormal hematopoietic system physiology 0.00500939111222009 0.0304666513243214 0.891130358513321 0.761904761904762 11.4 11 4 liver degeneration 0.00500939111222009 0.0304666513243214 0.891130358513321 0.761904761904762 11.4 11 4 left pulmonary isomerism 0.00500939111222009 0.0304666513243214 0.891130358513321 0.761904761904762 11.4 11 4 abnormal clavicle morphology 0.00500939111222009 0.0304666513243214 0.891130358513321 0.761904761904762 11.4 11 4 abnormal bone structure 1.29327491989863e-17 1.53191493487993e-15 0.890841780029346 0.761658031088083 11.4 11 4 rib fusion 5.24740655570448e-07 1.04007361014461e-05 0.890299080193812 0.761194029850746 11.4 11 4 abnormal myelin sheath morphology 3.32027132734132e-05 0.000436993382368335 0.889919583569689 0.760869565217391 11.4 11 4 decreased liver weight 2.55090477044369e-07 5.51771792737277e-06 0.889561467037065 0.76056338028169 11.4 11 4 abnormal keratinocyte physiology 0.00231945568712192 0.0161163296695971 0.888902532617038 0.76 11.4 11 4 increased cellular sensitivity to ionizing radiation 0.00231945568712192 0.0161163296695971 0.888902532617038 0.76 11.4 11 4 abnormal vertebrae development 0.00231945568712192 0.0161163296695971 0.888902532617038 0.76 11.4 11 4 increased liver glycogen level 0.00231945568712192 0.0161163296695971 0.888902532617038 0.76 11.4 11 4 decreased circulating glucose level 1.5965236904681e-24 3.78224064765658e-22 0.888734846796887 0.759856630824373 11.4 11 4 decreased circulating cholesterol level 1.47468592161895e-16 1.38425706793477e-14 0.888391228312973 0.759562841530055 11.4 11 4 abnormal myocardium layer morphology 6.04850685082926e-08 1.56725633244144e-06 0.888310325733216 0.759493670886076 11.4 11 4 decreased platelet aggregation 7.69918715434975e-06 0.000120073530071756 0.888036155879594 0.759259259259259 11.4 11 4 small spleen 7.0306780679006e-09 2.21377363213959e-07 0.886846077943545 0.758241758241758 11.4 11 4 decreased circulating HDL cholesterol level 6.88383722389773e-12 3.60495686198855e-10 0.886344013814275 0.7578125 11.4 11 4 increased mean corpuscular hemoglobin 1.68041380616026e-09 5.8055963094773e-08 0.88606711783995 0.757575757575758 11.4 11 4 abnormal QRS complex 0.000511624713751904 0.00468753766282821 0.88606711783995 0.757575757575758 11.4 11 4 cardiovascular system phenotype 0.000511624713751904 0.00468753766282821 0.88606711783995 0.757575757575758 11.4 11 4 ventricular septal defect 1.65849741640577e-12 9.48393637542383e-11 0.885806509864115 0.757352941176471 11.4 11 4 increased circulating alanine transaminase level 1.00382988315286e-07 2.42429789742014e-06 0.884703937658658 0.756410256410256 11.4 11 4 hemopericardium 0.000115682566914305 0.00128178345300372 0.884338206390506 0.75609756097561 11.4 11 4 palatal shelves fail to meet at midline 0.000115682566914305 0.00128178345300372 0.884338206390506 0.75609756097561 11.4 11 4 lethality at weaning, incomplete penetrance 0.000115682566914305 0.00128178345300372 0.884338206390506 0.75609756097561 11.4 11 4 perinatal lethality, complete penetrance 1.38443073360062e-18 1.76603664093925e-16 0.88407034687017 0.755868544600939 11.4 11 4 small placenta 5.53606502916013e-05 0.000690273772432874 0.883704272192377 0.755555555555556 11.4 11 4 polydactyly 2.78008920704649e-09 9.3452323007137e-08 0.883173837455166 0.755102040816326 11.4 11 4 abnormal respiratory system physiology 2.65806593871745e-05 0.000362298028633405 0.883173837455166 0.755102040816326 11.4 11 4 abnormal craniofacial development 2.65806593871745e-05 0.000362298028633405 0.883173837455166 0.755102040816326 11.4 11 4 abnormal craniofacial bone morphology 6.17642675166224e-06 9.75483272683163e-05 0.882336308922729 0.754385964912281 11.4 11 4 abnormal coat appearance 7.02120514309758e-07 1.37521636168939e-05 0.881444158964263 0.753623188405797 11.4 11 4 decreased percent body fat/body weight 3.4114221431893e-07 7.19145133998591e-06 0.881211955550416 0.753424657534247 11.4 11 4 increased exploration in new environment 8.08165303073962e-08 2.01031119139648e-06 0.880816349734232 0.753086419753086 11.4 11 4 increased neuron apoptosis 8.08165303073962e-08 2.01031119139648e-06 0.880816349734232 0.753086419753086 11.4 11 4 preweaning lethality, incomplete penetrance 1.01482716422212e-33 4.58978649273184e-31 0.880781045058704 0.753056234718826 11.4 11 4 postnatal lethality 1.52935968554772e-14 1.15281279327271e-12 0.880729364118022 0.753012048192771 11.4 11 4 hypoglycemia 9.383881821442e-09 2.84663488180939e-07 0.880350555789369 0.752688172043011 11.4 11 4 lethargy 9.383881821442e-09 2.84663488180939e-07 0.880350555789369 0.752688172043011 11.4 11 4 abnormal renal glomerulus morphology 5.36669606198004e-10 2.06971417894191e-08 0.879889035183451 0.752293577981651 11.4 11 4 perinatal lethality, incomplete penetrance 3.61998156560823e-19 5.45739645118211e-17 0.87979407629772 0.752212389380531 11.4 11 4 hypertension 9.17118041866956e-05 0.00106606579766855 0.87720644666155 0.75 11.4 11 4 abnormal astrocyte morphology 9.17118041866956e-05 0.00106606579766855 0.87720644666155 0.75 11.4 11 4 muscular atrophy 9.17118041866956e-05 0.00106606579766855 0.87720644666155 0.75 11.4 11 4 renal interstitial fibrosis 9.17118041866956e-05 0.00106606579766855 0.87720644666155 0.75 11.4 11 4 abnormal urine homeostasis 7.53691324603812e-09 2.35824801251822e-07 0.87720644666155 0.75 11.4 11 4 abnormal axial skeleton morphology 2.73258008804036e-07 5.88510213766268e-06 0.87720644666155 0.75 11.4 11 4 abnormal kidney development 4.92921629860334e-06 7.83477670464908e-05 0.87720644666155 0.75 11.4 11 4 intracranial hemorrhage 4.92921629860334e-06 7.83477670464908e-05 0.87720644666155 0.75 11.4 11 4 hemolytic anemia 0.00388574776028952 0.024470373553722 0.87720644666155 0.75 11.4 11 4 prolonged QT interval 0.00388574776028952 0.024470373553722 0.87720644666155 0.75 11.4 11 4 decreased fatty acid level 0.00388574776028952 0.024470373553722 0.87720644666155 0.75 11.4 11 4 increased body temperature 0.00388574776028952 0.024470373553722 0.87720644666155 0.75 11.4 11 4 abnormal truncus arteriosus septation 0.00388574776028952 0.024470373553722 0.87720644666155 0.75 11.4 11 4 abnormal adipose tissue distribution 0.0420111869459452 0.1538849317734 0.87720644666155 0.75 11.4 11 4 abnormal mating frequency 0.0420111869459452 0.1538849317734 0.87720644666155 0.75 11.4 11 4 myocarditis 0.0420111869459452 0.1538849317734 0.87720644666155 0.75 11.4 11 4 abnormal respiratory function 0.0420111869459452 0.1538849317734 0.87720644666155 0.75 11.4 11 4 increased urine phosphate level 0.0420111869459452 0.1538849317734 0.87720644666155 0.75 11.4 11 4 decreased circulating ketone body level 0.0420111869459452 0.1538849317734 0.87720644666155 0.75 11.4 11 4 abnormal vascular endothelial cell development 0.0420111869459452 0.1538849317734 0.87720644666155 0.75 11.4 11 4 delayed somite formation 0.0420111869459452 0.1538849317734 0.87720644666155 0.75 11.4 11 4 increased hepatocyte proliferation 0.0420111869459452 0.1538849317734 0.87720644666155 0.75 11.4 11 4 abnormal fatty acid level 0.0420111869459452 0.1538849317734 0.87720644666155 0.75 11.4 11 4 abnormal thymus corticomedullary boundary morphology 0.0420111869459452 0.1538849317734 0.87720644666155 0.75 11.4 11 4 decreased mammary gland epithelial cell proliferation 0.0420111869459452 0.1538849317734 0.87720644666155 0.75 11.4 11 4 decreased heart rate 3.68390437262943e-09 1.21373670555175e-07 0.87720644666155 0.75 11.4 11 4 decreased caudal vertebrae number 2.38641759636874e-06 4.15119844123584e-05 0.87720644666155 0.75 11.4 11 4 increased sacral vertebrae number 2.38641759636874e-06 4.15119844123584e-05 0.87720644666155 0.75 11.4 11 4 eyelids open at birth 2.11544009883851e-05 0.000289926019055692 0.87720644666155 0.75 11.4 11 4 heart right ventricle hypertrophy 0.0004033085972834 0.00377864457906764 0.87720644666155 0.75 11.4 11 4 abnormal retinal blood vessel morphology 0.0004033085972834 0.00377864457906764 0.87720644666155 0.75 11.4 11 4 abnormal vertebral body morphology 0.000852002565609751 0.00698305232933857 0.87720644666155 0.75 11.4 11 4 failure of primitive streak formation 0.000852002565609751 0.00698305232933857 0.87720644666155 0.75 11.4 11 4 abnormal depression-related behavior 0.000852002565609751 0.00698305232933857 0.87720644666155 0.75 11.4 11 4 abnormal spongiotrophoblast layer morphology 0.000852002565609751 0.00698305232933857 0.87720644666155 0.75 11.4 11 4 increased fatty acid level 0.000852002565609751 0.00698305232933857 0.87720644666155 0.75 11.4 11 4 myoclonus 0.00181178002641208 0.0133140408144758 0.87720644666155 0.75 11.4 11 4 absent corpus callosum 0.00181178002641208 0.0133140408144758 0.87720644666155 0.75 11.4 11 4 straub tail 0.00181178002641208 0.0133140408144758 0.87720644666155 0.75 11.4 11 4 abnormal tympanic ring morphology 0.0185874252169493 0.0855434231769866 0.87720644666155 0.75 11.4 11 4 vasculature congestion 0.0185874252169493 0.0855434231769866 0.87720644666155 0.75 11.4 11 4 delayed hair appearance 0.0185874252169493 0.0855434231769866 0.87720644666155 0.75 11.4 11 4 disorganized retinal layers 0.0185874252169493 0.0855434231769866 0.87720644666155 0.75 11.4 11 4 abnormal olfaction 0.0185874252169493 0.0855434231769866 0.87720644666155 0.75 11.4 11 4 abnormal molar crown morphology 0.0185874252169493 0.0855434231769866 0.87720644666155 0.75 11.4 11 4 increased thymus weight 0.0185874252169493 0.0855434231769866 0.87720644666155 0.75 11.4 11 4 abnormal amnion morphology 0.0185874252169493 0.0855434231769866 0.87720644666155 0.75 11.4 11 4 decreased circulating triiodothyronine level 0.0185874252169493 0.0855434231769866 0.87720644666155 0.75 11.4 11 4 abnormal thoracic cage shape 0.0185874252169493 0.0855434231769866 0.87720644666155 0.75 11.4 11 4 increased heart left ventricle size 0.0185874252169493 0.0855434231769866 0.87720644666155 0.75 11.4 11 4 abnormal pulmonary alveolus wall morphology 0.0185874252169493 0.0855434231769866 0.87720644666155 0.75 11.4 11 4 abnormal exoccipital bone morphology 0.0990851170918717 0.26790677039786 0.87720644666155 0.75 11.4 11 4 abnormal bone marrow development 0.0990851170918717 0.26790677039786 0.87720644666155 0.75 11.4 11 4 abnormal esophageal epithelium morphology 0.0990851170918717 0.26790677039786 0.87720644666155 0.75 11.4 11 4 abnormal vagus ganglion morphology 0.0990851170918717 0.26790677039786 0.87720644666155 0.75 11.4 11 4 dermal cysts 0.0990851170918717 0.26790677039786 0.87720644666155 0.75 11.4 11 4 absent eyelids 0.0990851170918717 0.26790677039786 0.87720644666155 0.75 11.4 11 4 spinning 0.0990851170918717 0.26790677039786 0.87720644666155 0.75 11.4 11 4 abnormal atrial thrombosis 0.0990851170918717 0.26790677039786 0.87720644666155 0.75 11.4 11 4 abnormal hepatobiliary system morphology 0.0990851170918717 0.26790677039786 0.87720644666155 0.75 11.4 11 4 abnormal secondary sex determination 0.0990851170918717 0.26790677039786 0.87720644666155 0.75 11.4 11 4 coarse hair 0.0990851170918717 0.26790677039786 0.87720644666155 0.75 11.4 11 4 abnormal soft palate morphology 0.0990851170918717 0.26790677039786 0.87720644666155 0.75 11.4 11 4 abnormal cellular cholesterol metabolism 0.0990851170918717 0.26790677039786 0.87720644666155 0.75 11.4 11 4 loss of GABAergic neurons 0.0990851170918717 0.26790677039786 0.87720644666155 0.75 11.4 11 4 abnormal perineum morphology 0.0990851170918717 0.26790677039786 0.87720644666155 0.75 11.4 11 4 increased cardiac output 0.0990851170918717 0.26790677039786 0.87720644666155 0.75 11.4 11 4 abnormal eyelid aperture 0.0990851170918717 0.26790677039786 0.87720644666155 0.75 11.4 11 4 increased left ventricle systolic pressure 0.0990851170918717 0.26790677039786 0.87720644666155 0.75 11.4 11 4 abnormal miscarriage rate 0.0990851170918717 0.26790677039786 0.87720644666155 0.75 11.4 11 4 abnormal lateral ganglionic eminence morphology 0.0990851170918717 0.26790677039786 0.87720644666155 0.75 11.4 11 4 long femur 0.0990851170918717 0.26790677039786 0.87720644666155 0.75 11.4 11 4 absent interparietal bone 0.0990851170918717 0.26790677039786 0.87720644666155 0.75 11.4 11 4 abnormal choroid pigmentation 0.0990851170918717 0.26790677039786 0.87720644666155 0.75 11.4 11 4 non-pigmented tail tip 0.0990851170918717 0.26790677039786 0.87720644666155 0.75 11.4 11 4 abnormal canal of Schlemm morphology 0.0990851170918717 0.26790677039786 0.87720644666155 0.75 11.4 11 4 abnormal ilium morphology 0.0990851170918717 0.26790677039786 0.87720644666155 0.75 11.4 11 4 increased pulmonary ventilation 0.0990851170918717 0.26790677039786 0.87720644666155 0.75 11.4 11 4 absent outer ear 0.0990851170918717 0.26790677039786 0.87720644666155 0.75 11.4 11 4 abnormal epidermal lamellar body morphology 0.0990851170918717 0.26790677039786 0.87720644666155 0.75 11.4 11 4 abnormal meiotic spindle morphology 0.0990851170918717 0.26790677039786 0.87720644666155 0.75 11.4 11 4 abnormal olfactory bulb mitral cell layer morphology 0.0990851170918717 0.26790677039786 0.87720644666155 0.75 11.4 11 4 abnormal lateral plate mesoderm morphology 0.0990851170918717 0.26790677039786 0.87720644666155 0.75 11.4 11 4 pleural effusion 0.0990851170918717 0.26790677039786 0.87720644666155 0.75 11.4 11 4 heart right ventricle hypoplasia 0.0990851170918717 0.26790677039786 0.87720644666155 0.75 11.4 11 4 increased heart right ventricle size 0.0990851170918717 0.26790677039786 0.87720644666155 0.75 11.4 11 4 abnormal heart right ventricle pressure 0.0990851170918717 0.26790677039786 0.87720644666155 0.75 11.4 11 4 abnormal stomach position or orientation 0.0990851170918717 0.26790677039786 0.87720644666155 0.75 11.4 11 4 abnormal pulmonary acinus morphology 0.0990851170918717 0.26790677039786 0.87720644666155 0.75 11.4 11 4 abnormal branching involved in ureteric bud morphogenesis 0.0990851170918717 0.26790677039786 0.87720644666155 0.75 11.4 11 4 increased aorta wall thickness 0.0990851170918717 0.26790677039786 0.87720644666155 0.75 11.4 11 4 abnormal macrophage activation involved in immune response 0.0990851170918717 0.26790677039786 0.87720644666155 0.75 11.4 11 4 lethality during fetal growth through weaning, incomplete penetrance 0.0990851170918717 0.26790677039786 0.87720644666155 0.75 11.4 11 4 decreased cranium length 0.0990851170918717 0.26790677039786 0.87720644666155 0.75 11.4 11 4 abnormal heart echocardiography feature 0.0990851170918717 0.26790677039786 0.87720644666155 0.75 11.4 11 4 increased testis apoptosis 0.0990851170918717 0.26790677039786 0.87720644666155 0.75 11.4 11 4 absent hypoglossal canal 0.0990851170918717 0.26790677039786 0.87720644666155 0.75 11.4 11 4 increased brain apoptosis 0.0990851170918717 0.26790677039786 0.87720644666155 0.75 11.4 11 4 postnatal growth retardation 7.96937310896823e-49 4.95595390213962e-46 0.87720644666155 0.75 11.4 11 4 decreased circulating phosphate level 0.000191914425064536 0.00200582828717661 0.87720644666155 0.75 11.4 11 4 abnormal skin pigmentation 0.000191914425064536 0.00200582828717661 0.87720644666155 0.75 11.4 11 4 abnormal basioccipital bone morphology 0.00842991967455772 0.0461881612124721 0.87720644666155 0.75 11.4 11 4 abnormal cell proliferation 0.00842991967455772 0.0461881612124721 0.87720644666155 0.75 11.4 11 4 abnormal circulating enzyme level 0.00842991967455772 0.0461881612124721 0.87720644666155 0.75 11.4 11 4 increased mammary adenocarcinoma incidence 0.00842991967455772 0.0461881612124721 0.87720644666155 0.75 11.4 11 4 abnormal optic stalk morphology 0.00842991967455772 0.0461881612124721 0.87720644666155 0.75 11.4 11 4 abnormal sperm mitochondrial sheath morphology 0.00842991967455772 0.0461881612124721 0.87720644666155 0.75 11.4 11 4 anemia 1.34359444457668e-17 1.55450752599279e-15 0.87582065448673 0.748815165876777 11.4 11 4 hydroencephaly 3.46215492601501e-10 1.36700164737497e-08 0.874663819279923 0.747826086956522 11.4 11 4 abnormal heart development 2.24519691611618e-13 1.43203264842025e-11 0.873505153637662 0.746835443037975 11.4 11 4 decreased white adipose tissue amount 1.89870046778035e-06 3.4430180289401e-05 0.87284223548413 0.746268656716418 11.4 11 4 abnormal lipid homeostasis 3.26567723723497e-11 1.5473089766899e-09 0.872707952063286 0.746153846153846 11.4 11 4 decreased susceptibility to hepatic steatosis 3.91669229051876e-06 6.40971846885882e-05 0.87256514271096 0.746031746031746 11.4 11 4 increased circulating aspartate transaminase level 3.91669229051876e-06 6.40971846885882e-05 0.87256514271096 0.746031746031746 11.4 11 4 abnormal thoracic vertebrae morphology 8.09304039915006e-06 0.000125039987533452 0.872250478036344 0.745762711864407 11.4 11 4 abnormal joint morphology 1.67548420826265e-05 0.00023667972935234 0.871890043954511 0.745454545454545 11.4 11 4 decreased bone mineral content 5.84390661848241e-17 5.81468708539e-15 0.87158332841372 0.745192307692308 11.4 11 4 thin ventricular wall 4.12862352074329e-08 1.12239901725125e-06 0.870708621130724 0.744444444444444 11.4 11 4 increased circulating creatinine level 8.45968904609709e-08 2.08351252496698e-06 0.87040639668743 0.744186046511628 11.4 11 4 abnormal cornea morphology 3.5610488661245e-07 7.44378912141571e-06 0.869708955664443 0.743589743589744 11.4 11 4 abnormal dermal layer morphology 0.000664821620469098 0.00582304148210169 0.868852099550488 0.742857142857143 11.4 11 4 holoprosencephaly 0.000664821620469098 0.00582304148210169 0.868852099550488 0.742857142857143 11.4 11 4 increased red blood cell distribution width 0.000664821620469098 0.00582304148210169 0.868852099550488 0.742857142857143 11.4 11 4 impaired adaptive thermogenesis 0.000664821620469098 0.00582304148210169 0.868852099550488 0.742857142857143 11.4 11 4 decreased total body fat amount 7.23301866983314e-26 1.99912599346777e-23 0.868451891305647 0.74251497005988 11.4 11 4 increased lung adenoma incidence 0.00140616029419328 0.0106803778070406 0.867774119278093 0.741935483870968 11.4 11 4 abnormal postnatal growth/weight/body size 0.00140616029419328 0.0106803778070406 0.867774119278093 0.741935483870968 11.4 11 4 abnormal capillary morphology 0.00140616029419328 0.0106803778070406 0.867774119278093 0.741935483870968 11.4 11 4 abnormal coat/hair pigmentation 1.49480488942896e-09 5.23708051049935e-08 0.866763512772722 0.741071428571429 11.4 11 4 abnormal cell adhesion 2.73654498127706e-05 0.000368951525253478 0.866376737443507 0.740740740740741 11.4 11 4 abnormal neuronal precursor proliferation 2.73654498127706e-05 0.000368951525253478 0.866376737443507 0.740740740740741 11.4 11 4 abnormal skin appearance 0.00299473710120872 0.0195266278879599 0.866376737443507 0.740740740740741 11.4 11 4 decreased bone ossification 0.00299473710120872 0.0195266278879599 0.866376737443507 0.740740740740741 11.4 11 4 abnormal skeleton development 2.82165970964813e-07 6.05075735150839e-06 0.866376737443506 0.740740740740741 11.4 11 4 abnormal sternum morphology 2.44674603922651e-06 4.21195901216328e-05 0.864493309753412 0.739130434782609 11.4 11 4 decreased spleen weight 2.44674603922651e-06 4.21195901216328e-05 0.864493309753412 0.739130434782609 11.4 11 4 abnormal cranial nerve morphology 0.00643539728716618 0.0365898302898877 0.864493309753412 0.739130434782609 11.4 11 4 abnormal cardiovascular development 0.00643539728716618 0.0365898302898877 0.864493309753412 0.739130434782609 11.4 11 4 abnormal ulna morphology 0.00643539728716618 0.0365898302898877 0.864493309753412 0.739130434782609 11.4 11 4 abnormal basicranium morphology 0.00643539728716618 0.0365898302898877 0.864493309753412 0.739130434782609 11.4 11 4 abnormal cartilage morphology 0.00024655175985899 0.00250469814708751 0.86328253480978 0.738095238095238 11.4 11 4 abnormal optic nerve morphology 0.00024655175985899 0.00250469814708751 0.86328253480978 0.738095238095238 11.4 11 4 abnormal blood vessel morphology 1.04674600740776e-11 5.29682294809794e-10 0.863090480853204 0.737931034482759 11.4 11 4 ataxia 1.05738353687298e-15 9.06979844128116e-14 0.862731092756244 0.737623762376238 11.4 11 4 decreased total retina thickness 0.00051642901374373 0.00472285724885121 0.861816859878014 0.736842105263158 11.4 11 4 abnormal triglyceride level 0.0139975294737589 0.0683698149429249 0.861816859878014 0.736842105263158 11.4 11 4 enlarged adrenal glands 0.0139975294737589 0.0683698149429249 0.861816859878014 0.736842105263158 11.4 11 4 increased malignant tumor incidence 0.0139975294737589 0.0683698149429249 0.861816859878014 0.736842105263158 11.4 11 4 abnormal neurotransmitter level 0.0139975294737589 0.0683698149429249 0.861816859878014 0.736842105263158 11.4 11 4 abnormal neural crest cell migration 0.0139975294737589 0.0683698149429249 0.861816859878014 0.736842105263158 11.4 11 4 abnormal metatarsal bone morphology 0.0139975294737589 0.0683698149429249 0.861816859878014 0.736842105263158 11.4 11 4 osteoarthritis 0.0139975294737589 0.0683698149429249 0.861816859878014 0.736842105263158 11.4 11 4 eyelids fail to open 0.0139975294737589 0.0683698149429249 0.861816859878014 0.736842105263158 11.4 11 4 decreased circulating magnesium level 0.0139975294737589 0.0683698149429249 0.861816859878014 0.736842105263158 11.4 11 4 right-sided stomach 0.0139975294737589 0.0683698149429249 0.861816859878014 0.736842105263158 11.4 11 4 abnormal retinal pigmentation 1.75834300926504e-07 3.95826084664867e-06 0.860401725461137 0.735632183908046 11.4 11 4 abnormal bone mineralization 7.43271414809875e-10 2.73909280642898e-08 0.860290619866424 0.735537190082645 11.4 11 4 increased width of hypertrophic chondrocyte zone 0.00108654400653614 0.00862130212522698 0.860006320256422 0.735294117647059 11.4 11 4 decreased osteoblast cell number 0.00108654400653614 0.00862130212522698 0.860006320256422 0.735294117647059 11.4 11 4 premature death 1.59206244010565e-61 1.3200851065876e-58 0.859886458748372 0.735191637630662 11.4 11 4 abnormal long bone hypertrophic chondrocyte zone 9.21689352964426e-05 0.0010688588650345 0.859304274280702 0.73469387755102 11.4 11 4 increased insulin sensitivity 2.71110617654458e-11 1.30949060469022e-09 0.858803514214105 0.734265734265734 11.4 11 4 abnormal spermatogenesis 4.63878082143915e-14 3.11863980900807e-12 0.858136741299343 0.733695652173913 11.4 11 4 epidermal hyperplasia 1.67935566756535e-05 0.00023667972935234 0.857712970069071 0.733333333333333 11.4 11 4 abnormal long bone epiphyseal plate morphology 1.67935566756535e-05 0.00023667972935234 0.857712970069071 0.733333333333333 11.4 11 4 irregular heartbeat 0.000191677477398206 0.00200582828717661 0.857712970069071 0.733333333333333 11.4 11 4 albuminuria 0.000191677477398206 0.00200582828717661 0.857712970069071 0.733333333333333 11.4 11 4 abnormal heart tube morphology 0.00229863388402844 0.0160613814228111 0.857712970069071 0.733333333333333 11.4 11 4 abnormal response to new environment 0.00229863388402844 0.0160613814228111 0.857712970069071 0.733333333333333 11.4 11 4 abnormal lactation 0.00229863388402844 0.0160613814228111 0.857712970069071 0.733333333333333 11.4 11 4 enhanced paired-pulse facilitation 0.00229863388402844 0.0160613814228111 0.857712970069071 0.733333333333333 11.4 11 4 decreased hepatocyte number 0.0309755085360677 0.125695884964875 0.857712970069071 0.733333333333333 11.4 11 4 abnormal epidermis stratum spinosum morphology 0.0309755085360677 0.125695884964875 0.857712970069071 0.733333333333333 11.4 11 4 abnormal pup retrieval 0.0309755085360677 0.125695884964875 0.857712970069071 0.733333333333333 11.4 11 4 abnormal cricoid cartilage morphology 0.0309755085360677 0.125695884964875 0.857712970069071 0.733333333333333 11.4 11 4 decreased thymocyte apoptosis 0.0309755085360677 0.125695884964875 0.857712970069071 0.733333333333333 11.4 11 4 bicuspid aortic valve 0.0309755085360677 0.125695884964875 0.857712970069071 0.733333333333333 11.4 11 4 abnormal coronary vessel morphology 0.0309755085360677 0.125695884964875 0.857712970069071 0.733333333333333 11.4 11 4 kyphosis 1.05404114947075e-11 5.29682294809794e-10 0.857712970069071 0.733333333333333 11.4 11 4 delayed bone ossification 1.51164758621358e-06 2.78535064496761e-05 0.857712970069071 0.733333333333333 11.4 11 4 abnormal seminiferous tubule morphology 2.1405196998679e-11 1.04402799086694e-09 0.857178902217223 0.732876712328767 11.4 11 4 microphthalmia 8.31675918524036e-12 4.30998718193446e-10 0.856184069944171 0.73202614379085 11.4 11 4 abnormal myocardial fiber morphology 5.32551938429387e-08 1.41681598592845e-06 0.856105260659382 0.731958762886598 11.4 11 4 abnormal cholesterol homeostasis 0.00039981949274698 0.0037743870520232 0.855811167474683 0.731707317073171 11.4 11 4 increased bone trabecula number 0.00039981949274698 0.0037743870520232 0.855811167474683 0.731707317073171 11.4 11 4 abnormal definitive hematopoiesis 1.08672570078518e-07 2.58682313942885e-06 0.855197682766816 0.731182795698925 11.4 11 4 thrombocytopenia 3.42579182566996e-11 1.58864229701696e-09 0.855024214677005 0.731034482758621 11.4 11 4 increased urine protein level 1.18429119054837e-06 2.22646808913338e-05 0.854713973670228 0.730769230769231 11.4 11 4 abnormal snout morphology 7.1706090567296e-05 0.000870092196517799 0.854713973670228 0.730769230769231 11.4 11 4 abnormal brain wave pattern 7.1706090567296e-05 0.000870092196517799 0.854713973670228 0.730769230769231 11.4 11 4 abnormal leukocyte cell number 0.00489668611519309 0.0300012480579872 0.854713973670228 0.730769230769231 11.4 11 4 postnatal lethality, incomplete penetrance 1.55753457350765e-39 8.60970500355615e-37 0.854555575973106 0.730633802816901 11.4 11 4 abnormal skeleton morphology 3.89095312398776e-09 1.26519554195027e-07 0.854322800226901 0.730434782608696 11.4 11 4 increased granulocyte number 2.4260256173793e-06 4.20539283848851e-05 0.853498164319346 0.72972972972973 11.4 11 4 abnormal breathing pattern 0.000836972013564786 0.00691683682306447 0.853498164319346 0.72972972972973 11.4 11 4 skin inflammation 0.000836972013564786 0.00691683682306447 0.853498164319346 0.72972972972973 11.4 11 4 cardiac fibrosis 4.53163823577554e-07 9.08424134185436e-06 0.853126269694371 0.729411764705882 11.4 11 4 thymus atrophy 0.000148615508868658 0.00161432785288554 0.852839600920952 0.729166666666667 11.4 11 4 abnormal osteoclast morphology 0.000148615508868658 0.00161432785288554 0.852839600920952 0.729166666666667 11.4 11 4 abnormal locomotor behavior 1.73738242724043e-07 3.92885344341869e-06 0.851780172845273 0.728260869565217 11.4 11 4 osteoporosis 0.000308761086960729 0.00305993308292754 0.850624433126352 0.727272727272727 11.4 11 4 omphalocele 0.000308761086960729 0.00305993308292754 0.850624433126352 0.727272727272727 11.4 11 4 lethality, incomplete penetrance 0.000308761086960729 0.00305993308292754 0.850624433126352 0.727272727272727 11.4 11 4 abnormal long bone epiphysis morphology 0.0105254890490683 0.0547171452655328 0.850624433126352 0.727272727272727 11.4 11 4 abnormal facial nerve morphology 0.0105254890490683 0.0547171452655328 0.850624433126352 0.727272727272727 11.4 11 4 increased myocardial infarction size 0.0105254890490683 0.0547171452655328 0.850624433126352 0.727272727272727 11.4 11 4 abnormal cochlear sensory epithelium morphology 0.0105254890490683 0.0547171452655328 0.850624433126352 0.727272727272727 11.4 11 4 parakeratosis 0.0105254890490683 0.0547171452655328 0.850624433126352 0.727272727272727 11.4 11 4 abnormal circulating lipid level 0.0105254890490683 0.0547171452655328 0.850624433126352 0.727272727272727 11.4 11 4 abnormal mesenteric lymph node morphology 0.0105254890490683 0.0547171452655328 0.850624433126352 0.727272727272727 11.4 11 4 abnormal ear position 0.0703899940278156 0.224731238395969 0.850624433126352 0.727272727272727 11.4 11 4 premature suture closure 0.0703899940278156 0.224731238395969 0.850624433126352 0.727272727272727 11.4 11 4 abnormal awl hair morphology 0.0703899940278156 0.224731238395969 0.850624433126352 0.727272727272727 11.4 11 4 abnormal stomach epithelium morphology 0.0703899940278156 0.224731238395969 0.850624433126352 0.727272727272727 11.4 11 4 abnormal large intestine morphology 0.0703899940278156 0.224731238395969 0.850624433126352 0.727272727272727 11.4 11 4 abnormal sebaceous gland morphology 0.0703899940278156 0.224731238395969 0.850624433126352 0.727272727272727 11.4 11 4 abnormal food preference 0.0703899940278156 0.224731238395969 0.850624433126352 0.727272727272727 11.4 11 4 abnormal hemoglobin 0.0703899940278156 0.224731238395969 0.850624433126352 0.727272727272727 11.4 11 4 impaired myelopoiesis 0.0703899940278156 0.224731238395969 0.850624433126352 0.727272727272727 11.4 11 4 focal hepatic necrosis 0.0703899940278156 0.224731238395969 0.850624433126352 0.727272727272727 11.4 11 4 abnormal fear/anxiety-related behavior 0.0703899940278156 0.224731238395969 0.850624433126352 0.727272727272727 11.4 11 4 fused joints 0.0703899940278156 0.224731238395969 0.850624433126352 0.727272727272727 11.4 11 4 dilated renal glomerular capsule 0.0703899940278156 0.224731238395969 0.850624433126352 0.727272727272727 11.4 11 4 pathological neovascularization 0.0703899940278156 0.224731238395969 0.850624433126352 0.727272727272727 11.4 11 4 abnormal hair medulla 0.0703899940278156 0.224731238395969 0.850624433126352 0.727272727272727 11.4 11 4 pharyngeal arch hypoplasia 0.0703899940278156 0.224731238395969 0.850624433126352 0.727272727272727 11.4 11 4 abnormal crista ampullaris neuroepithelium morphology 0.0703899940278156 0.224731238395969 0.850624433126352 0.727272727272727 11.4 11 4 increased circulating triiodothyronine level 0.0703899940278156 0.224731238395969 0.850624433126352 0.727272727272727 11.4 11 4 abnormal palate development 0.0703899940278156 0.224731238395969 0.850624433126352 0.727272727272727 11.4 11 4 abnormal aorta smooth muscle morphology 0.0703899940278156 0.224731238395969 0.850624433126352 0.727272727272727 11.4 11 4 abnormal pulmonary alveolar sac morphology 0.0703899940278156 0.224731238395969 0.850624433126352 0.727272727272727 11.4 11 4 decreased colon length 0.0703899940278156 0.224731238395969 0.850624433126352 0.727272727272727 11.4 11 4 abnormal skin morphology 1.02072288663815e-05 0.000150239537308426 0.850624433126352 0.727272727272727 11.4 11 4 decreased circulating calcium level 5.56604037598214e-05 0.000690549897020228 0.850624433126352 0.727272727272727 11.4 11 4 abnormal rostral-caudal axis patterning 5.56604037598214e-05 0.000690549897020228 0.850624433126352 0.727272727272727 11.4 11 4 abnormal tooth development 0.00175967683723067 0.0129887125596774 0.850624433126352 0.727272727272727 11.4 11 4 diarrhea 0.00175967683723067 0.0129887125596774 0.850624433126352 0.727272727272727 11.4 11 4 decreased sensitivity to xenobiotic induced morbidity/mortality 0.00175967683723067 0.0129887125596774 0.850624433126352 0.727272727272727 11.4 11 4 myeloid hyperplasia 0.00175967683723067 0.0129887125596774 0.850624433126352 0.727272727272727 11.4 11 4 prenatal lethality, incomplete penetrance 3.11005910062511e-21 5.73057186133701e-19 0.850274669790362 0.726973684210526 11.4 11 4 impaired righting response 1.35853825705358e-07 3.11462111928183e-06 0.849505190451185 0.726315789473684 11.4 11 4 abnormal kidney morphology 9.706053755472e-13 5.61483923645037e-11 0.848801666483938 0.725714285714286 11.4 11 4 decreased body size 4.078319931478e-53 2.89852023701472e-50 0.848625785492126 0.725563909774436 11.4 11 4 kinked tail 5.21695965122601e-08 1.39539646585212e-06 0.84853956931967 0.725490196078431 11.4 11 4 increased lung adenocarcinoma incidence 0.000114982656451537 0.00128178345300372 0.84853956931967 0.725490196078431 11.4 11 4 abnormal gluconeogenesis 0.000114982656451537 0.00128178345300372 0.84853956931967 0.725490196078431 11.4 11 4 increased kidney weight 0.000114982656451537 0.00128178345300372 0.84853956931967 0.725490196078431 11.4 11 4 abnormal posture 1.47612923527498e-06 2.7300159648673e-05 0.847966231772832 0.725 11.4 11 4 microcephaly 7.93611816587083e-06 0.000123381837110023 0.847542460542561 0.72463768115942 11.4 11 4 decreased body weight 8.90064420861064e-82 2.2140352468919e-78 0.847446615676263 0.724555735056543 11.4 11 4 dermatitis 4.31254674580908e-05 0.000548719183130439 0.846957948500807 0.724137931034483 11.4 11 4 abnormal parietal bone morphology 0.00371925294003273 0.0235710616263221 0.846957948500807 0.724137931034483 11.4 11 4 abnormal cranium morphology 5.67331537592557e-10 2.1382381814568e-08 0.846656968419606 0.723880597014925 11.4 11 4 pulmonary hypoplasia 0.000237982316037659 0.00243113351599046 0.846099835077807 0.723404255319149 11.4 11 4 neonatal lethality, incomplete penetrance 7.14633604276029e-18 8.88825545318312e-16 0.8457169844737 0.723076923076923 11.4 11 4 abnormal axon morphology 3.17829890613188e-08 8.73593207624647e-07 0.844717319007419 0.722222222222222 11.4 11 4 diluted coat color 8.88099641544148e-05 0.00104451435382556 0.844717319007419 0.722222222222222 11.4 11 4 abnormal mandible morphology 8.88099641544148e-05 0.00104451435382556 0.844717319007419 0.722222222222222 11.4 11 4 impaired limb coordination 8.88099641544148e-05 0.00104451435382556 0.844717319007419 0.722222222222222 11.4 11 4 axon degeneration 8.88099641544148e-05 0.00104451435382556 0.844717319007419 0.722222222222222 11.4 11 4 abnormal limb bone morphology 0.00134475548075191 0.0104704176366285 0.844717319007419 0.722222222222222 11.4 11 4 short radius 0.00134475548075191 0.0104704176366285 0.844717319007419 0.722222222222222 11.4 11 4 abnormal megakaryocyte differentiation 0.0229006559148253 0.0965514942171661 0.844717319007419 0.722222222222222 11.4 11 4 abnormal mammary gland morphology 0.0229006559148253 0.0965514942171661 0.844717319007419 0.722222222222222 11.4 11 4 abnormal thyroid cartilage morphology 0.0229006559148253 0.0965514942171661 0.844717319007419 0.722222222222222 11.4 11 4 abnormal metacarpal bone morphology 0.0229006559148253 0.0965514942171661 0.844717319007419 0.722222222222222 11.4 11 4 abnormal redox activity 0.0229006559148253 0.0965514942171661 0.844717319007419 0.722222222222222 11.4 11 4 increased circulating renin level 0.0229006559148253 0.0965514942171661 0.844717319007419 0.722222222222222 11.4 11 4 abnormal anterior eye segment morphology 0.0229006559148253 0.0965514942171661 0.844717319007419 0.722222222222222 11.4 11 4 primary atelectasis 0.0229006559148253 0.0965514942171661 0.844717319007419 0.722222222222222 11.4 11 4 hunched posture 2.3423752869608e-06 4.13238193355673e-05 0.843894809446555 0.721518987341772 11.4 11 4 abnormal maternal nurturing 3.33625141739099e-05 0.000437938015871245 0.843652101707283 0.721311475409836 11.4 11 4 increased oxygen consumption 8.93158483014004e-07 1.72227265619948e-05 0.843206196790947 0.720930232558139 11.4 11 4 abnormal vasculogenesis 0.000493633893088285 0.00453942443274347 0.843206196790947 0.720930232558139 11.4 11 4 kidney inflammation 0.000183155812936311 0.00193050883338591 0.842118188795088 0.72 11.4 11 4 abnormal circulating protein level 0.000183155812936311 0.00193050883338591 0.842118188795088 0.72 11.4 11 4 decreased respiratory quotient 0.000183155812936311 0.00193050883338591 0.842118188795088 0.72 11.4 11 4 abnormal thyroid gland morphology 0.0079133559484348 0.0441355895106089 0.842118188795088 0.72 11.4 11 4 spontaneous skin ulceration 0.0079133559484348 0.0441355895106089 0.842118188795088 0.72 11.4 11 4 decreased hematocrit 2.10821222582401e-10 8.81374438947431e-09 0.841156866661761 0.719178082191781 11.4 11 4 enlarged spleen 4.94402511407736e-19 7.23427204192201e-17 0.840656178050652 0.71875 11.4 11 4 kidney cortex cysts 0.00282234115612896 0.0186222112092063 0.840656178050652 0.71875 11.4 11 4 abnormal lymphatic vessel morphology 0.00282234115612896 0.0186222112092063 0.840656178050652 0.71875 11.4 11 4 abnormal lumbar vertebrae morphology 0.00282234115612896 0.0186222112092063 0.840656178050652 0.71875 11.4 11 4 abnormal heart looping 0.00102650159936465 0.00822358366640762 0.839718991676014 0.717948717948718 11.4 11 4 atrial septal defect 0.000378345799191855 0.00363007128017018 0.839067035937135 0.717391304347826 11.4 11 4 abnormal placenta development 0.000140796981497605 0.00153948347901228 0.838587294921734 0.716981132075472 11.4 11 4 decreased grip strength 1.24100668111804e-14 9.49847421317267e-13 0.838486527402517 0.71689497716895 11.4 11 4 muscular ventricular septal defect 5.27770862543721e-05 0.000665849540800977 0.838219493476593 0.716666666666667 11.4 11 4 increased or absent threshold for auditory brainstem response 9.48877589993198e-19 1.31129611394893e-16 0.837747333143903 0.716262975778547 11.4 11 4 abnormal intestine morphology 7.53351944663708e-06 0.000117859305808237 0.837692642757877 0.716216216216216 11.4 11 4 hypoactivity 5.33959084385083e-24 1.10685268533991e-21 0.837650718297502 0.716180371352785 11.4 11 4 hyperglycemia 1.09137616516583e-06 2.08830631603846e-05 0.837333426358753 0.715909090909091 11.4 11 4 alopecia 4.17064971936735e-07 8.50368129256253e-06 0.837193521024357 0.715789473684211 11.4 11 4 enlarged heart 2.91831458758841e-15 2.41976917887539e-13 0.836875115780559 0.71551724137931 11.4 11 4 abnormal gait 8.63446575111691e-20 1.43188223706022e-17 0.836516179987929 0.715210355987055 11.4 11 4 abnormal cardiovascular system physiology 2.70909165733798e-09 9.23132259949072e-08 0.835434711106238 0.714285714285714 11.4 11 4 spleen hypoplasia 1.23788609534248e-07 2.85114968718927e-06 0.835434711106238 0.714285714285714 11.4 11 4 thick epidermis 1.5341622477026e-05 0.000220591248043943 0.835434711106238 0.714285714285714 11.4 11 4 abnormal hair follicle morphology 4.06255967025458e-05 0.00052633422811241 0.835434711106238 0.714285714285714 11.4 11 4 absent kidney 0.000289731942799201 0.00289441047274302 0.835434711106238 0.714285714285714 11.4 11 4 decreased circulating creatinine level 0.000289731942799201 0.00289441047274302 0.835434711106238 0.714285714285714 11.4 11 4 abnormal reproductive system morphology 0.000782988824966959 0.0066023210240858 0.835434711106238 0.714285714285714 11.4 11 4 increased carcinoma incidence 0.00214084997170375 0.0151503963146887 0.835434711106238 0.714285714285714 11.4 11 4 decreased circulating thyroxine level 0.00214084997170375 0.0151503963146887 0.835434711106238 0.714285714285714 11.4 11 4 decreased bone volume 0.00214084997170375 0.0151503963146887 0.835434711106238 0.714285714285714 11.4 11 4 rib bifurcation 0.0059521297882003 0.0347149421996442 0.835434711106238 0.714285714285714 11.4 11 4 shortened head 0.0059521297882003 0.0347149421996442 0.835434711106238 0.714285714285714 11.4 11 4 failure of blastocyst to hatch from the zona pellucida 0.0059521297882003 0.0347149421996442 0.835434711106238 0.714285714285714 11.4 11 4 trunk curl 0.0169812410804018 0.0807664190965571 0.835434711106238 0.714285714285714 11.4 11 4 increased keratinocyte proliferation 0.0169812410804018 0.0807664190965571 0.835434711106238 0.714285714285714 11.4 11 4 decreased vocalization 0.0169812410804018 0.0807664190965571 0.835434711106238 0.714285714285714 11.4 11 4 abnormal pinna reflex 0.050689415656456 0.173081566843424 0.835434711106238 0.714285714285714 11.4 11 4 increased lactate dehydrogenase level 0.050689415656456 0.173081566843424 0.835434711106238 0.714285714285714 11.4 11 4 intestinal obstruction 0.050689415656456 0.173081566843424 0.835434711106238 0.714285714285714 11.4 11 4 abnormal ventral body wall morphology 0.050689415656456 0.173081566843424 0.835434711106238 0.714285714285714 11.4 11 4 abnormal maternal decidual layer morphology 0.050689415656456 0.173081566843424 0.835434711106238 0.714285714285714 11.4 11 4 decreased CNS synapse formation 0.050689415656456 0.173081566843424 0.835434711106238 0.714285714285714 11.4 11 4 premature hair loss 0.050689415656456 0.173081566843424 0.835434711106238 0.714285714285714 11.4 11 4 abnormal glucose tolerance 0.050689415656456 0.173081566843424 0.835434711106238 0.714285714285714 11.4 11 4 sternebra fusion 0.050689415656456 0.173081566843424 0.835434711106238 0.714285714285714 11.4 11 4 abnormal renal reabsorbtion 0.050689415656456 0.173081566843424 0.835434711106238 0.714285714285714 11.4 11 4 pulmonary alveolar hemorrhage 0.050689415656456 0.173081566843424 0.835434711106238 0.714285714285714 11.4 11 4 growth retardation of molars 0.167523424941016 0.397438740620674 0.835434711106238 0.714285714285714 11.4 11 4 failure of atrioventricular cushion closure 0.167523424941016 0.397438740620674 0.835434711106238 0.714285714285714 11.4 11 4 abnormal foot pad morphology 0.167523424941016 0.397438740620674 0.835434711106238 0.714285714285714 11.4 11 4 prostate gland epithelial hyperplasia 0.167523424941016 0.397438740620674 0.835434711106238 0.714285714285714 11.4 11 4 skin photosensitivity 0.167523424941016 0.397438740620674 0.835434711106238 0.714285714285714 11.4 11 4 retina hyperplasia 0.167523424941016 0.397438740620674 0.835434711106238 0.714285714285714 11.4 11 4 abnormal lacrimal gland morphology 0.167523424941016 0.397438740620674 0.835434711106238 0.714285714285714 11.4 11 4 excessive tearing 0.167523424941016 0.397438740620674 0.835434711106238 0.714285714285714 11.4 11 4 abnormal liquid preference 0.167523424941016 0.397438740620674 0.835434711106238 0.714285714285714 11.4 11 4 absent amniotic folds 0.167523424941016 0.397438740620674 0.835434711106238 0.714285714285714 11.4 11 4 abnormal gastrulation movements 0.167523424941016 0.397438740620674 0.835434711106238 0.714285714285714 11.4 11 4 abnormal melanocyte morphology 0.167523424941016 0.397438740620674 0.835434711106238 0.714285714285714 11.4 11 4 detached tectorial membrane 0.167523424941016 0.397438740620674 0.835434711106238 0.714285714285714 11.4 11 4 calcinosis 0.167523424941016 0.397438740620674 0.835434711106238 0.714285714285714 11.4 11 4 abnormal sinus venosus morphology 0.167523424941016 0.397438740620674 0.835434711106238 0.714285714285714 11.4 11 4 abnormal thyroid gland development 0.167523424941016 0.397438740620674 0.835434711106238 0.714285714285714 11.4 11 4 abnormal response to novel odor 0.167523424941016 0.397438740620674 0.835434711106238 0.714285714285714 11.4 11 4 abnormal locus ceruleus morphology 0.167523424941016 0.397438740620674 0.835434711106238 0.714285714285714 11.4 11 4 abnormal hard palate morphology 0.167523424941016 0.397438740620674 0.835434711106238 0.714285714285714 11.4 11 4 absent vestibular saccule 0.167523424941016 0.397438740620674 0.835434711106238 0.714285714285714 11.4 11 4 abnormal cochlear nerve compound action potential 0.167523424941016 0.397438740620674 0.835434711106238 0.714285714285714 11.4 11 4 abnormal ciliary body morphology 0.167523424941016 0.397438740620674 0.835434711106238 0.714285714285714 11.4 11 4 increased thyroid-stimulating hormone level 0.167523424941016 0.397438740620674 0.835434711106238 0.714285714285714 11.4 11 4 abnormal thyroid hormone level 0.167523424941016 0.397438740620674 0.835434711106238 0.714285714285714 11.4 11 4 retinal pigment epithelium atrophy 0.167523424941016 0.397438740620674 0.835434711106238 0.714285714285714 11.4 11 4 abnormal uterus physiology 0.167523424941016 0.397438740620674 0.835434711106238 0.714285714285714 11.4 11 4 abnormal spinal cord central canal morphology 0.167523424941016 0.397438740620674 0.835434711106238 0.714285714285714 11.4 11 4 heart hemorrhage 0.167523424941016 0.397438740620674 0.835434711106238 0.714285714285714 11.4 11 4 postaxial polydactyly 0.167523424941016 0.397438740620674 0.835434711106238 0.714285714285714 11.4 11 4 decreased DN2 thymocyte number 0.167523424941016 0.397438740620674 0.835434711106238 0.714285714285714 11.4 11 4 decreased DN4 thymocyte number 0.167523424941016 0.397438740620674 0.835434711106238 0.714285714285714 11.4 11 4 focal dorsal hair loss 0.167523424941016 0.397438740620674 0.835434711106238 0.714285714285714 11.4 11 4 decreased skeletal muscle glycogen level 0.167523424941016 0.397438740620674 0.835434711106238 0.714285714285714 11.4 11 4 long stride length 0.167523424941016 0.397438740620674 0.835434711106238 0.714285714285714 11.4 11 4 abnormal conotruncal ridge morphology 0.167523424941016 0.397438740620674 0.835434711106238 0.714285714285714 11.4 11 4 thick mitral valve cusps 0.167523424941016 0.397438740620674 0.835434711106238 0.714285714285714 11.4 11 4 small lung saccule 0.167523424941016 0.397438740620674 0.835434711106238 0.714285714285714 11.4 11 4 dilated pulmonary alveolar ducts 0.167523424941016 0.397438740620674 0.835434711106238 0.714285714285714 11.4 11 4 small lung lobe 0.167523424941016 0.397438740620674 0.835434711106238 0.714285714285714 11.4 11 4 abnormal brain ependyma motile cilium physiology 0.167523424941016 0.397438740620674 0.835434711106238 0.714285714285714 11.4 11 4 embryonic lethality at implantation, incomplete penetrance 0.167523424941016 0.397438740620674 0.835434711106238 0.714285714285714 11.4 11 4 increased circulating lactate dehydrogenase level 0.167523424941016 0.397438740620674 0.835434711106238 0.714285714285714 11.4 11 4 abnormal tectorial membrane striated-sheet matrix morphology 0.167523424941016 0.397438740620674 0.835434711106238 0.714285714285714 11.4 11 4 decreased collagen level 0.167523424941016 0.397438740620674 0.835434711106238 0.714285714285714 11.4 11 4 increased abdominal adipose tissue amount 0.167523424941016 0.397438740620674 0.835434711106238 0.714285714285714 11.4 11 4 abnormal retinal pigment epithelium morphology 4.48915898026915e-06 7.25115776845423e-05 0.833346124328473 0.7125 11.4 11 4 decreased bone marrow cell number 1.18213764121056e-05 0.000172974551912428 0.83314584888403 0.712328767123288 11.4 11 4 increased heart weight 1.63071416799237e-09 5.67328880123218e-08 0.833030582441184 0.712230215827338 11.4 11 4 abnormal vascular development 3.12484731763951e-05 0.000412646743049769 0.832903090769553 0.712121212121212 11.4 11 4 increased hemoglobin content 8.29923057448907e-05 0.000994907761640557 0.832602729034692 0.711864406779661 11.4 11 4 cachexia 1.93383788957353e-07 4.2759304447237e-06 0.832221500678907 0.711538461538462 11.4 11 4 decreased kidney weight 0.000221731518966 0.00226978252439475 0.832221500678907 0.711538461538462 11.4 11 4 abnormal autopod morphology 0.000596966895114626 0.00539983691490048 0.831721667945766 0.711111111111111 11.4 11 4 abnormal cell migration 0.000596966895114626 0.00539983691490048 0.831721667945766 0.711111111111111 11.4 11 4 abnormal frontal bone morphology 0.0016237593767619 0.0121843180986281 0.831037686310942 0.710526315789474 11.4 11 4 infertility 1.49495807268071e-07 3.4116589043975e-06 0.830750030483213 0.710280373831776 11.4 11 4 abnormal retinal photoreceptor layer morphology 0.00448023599251441 0.0275515130565627 0.830044809744263 0.709677419354839 11.4 11 4 decreased neuronal precursor cell number 0.00448023599251441 0.0275515130565627 0.830044809744263 0.709677419354839 11.4 11 4 abnormal podocyte morphology 0.00448023599251441 0.0275515130565627 0.830044809744263 0.709677419354839 11.4 11 4 abnormal mitochondrial ATP synthesis coupled electron transport 0.00448023599251441 0.0275515130565627 0.830044809744263 0.709677419354839 11.4 11 4 increased circulating calcium level 0.000169612017616235 0.00181857712853614 0.829358822298193 0.709090909090909 11.4 11 4 abnormal platelet physiology 0.000169612017616235 0.00181857712853614 0.829358822298193 0.709090909090909 11.4 11 4 hyperactivity 2.25877108154225e-22 4.32207158872027e-20 0.829129543475248 0.708894878706199 11.4 11 4 abnormal glucose homeostasis 1.01887698618577e-11 5.22568351162288e-10 0.829008290251575 0.708791208791209 11.4 11 4 retinal degeneration 7.85718851332808e-07 1.52099271804697e-05 0.828472755180353 0.708333333333333 11.4 11 4 abnormal digit morphology 1.84555292014314e-05 0.000258735663071024 0.828472755180353 0.708333333333333 11.4 11 4 abnormal kidney physiology 0.000455015990590943 0.0042154647172997 0.828472755180353 0.708333333333333 11.4 11 4 abnormal malleus morphology 0.0126274032810095 0.0625710471344843 0.828472755180353 0.708333333333333 11.4 11 4 abnormal digestive system morphology 0.0126274032810095 0.0625710471344843 0.828472755180353 0.708333333333333 11.4 11 4 decreased body height 0.0126274032810095 0.0625710471344843 0.828472755180353 0.708333333333333 11.4 11 4 abnormal body weight 0.0126274032810095 0.0625710471344843 0.828472755180353 0.708333333333333 11.4 11 4 abnormal nursing 0.0126274032810095 0.0625710471344843 0.828472755180353 0.708333333333333 11.4 11 4 abnormal impulse conducting system conduction 0.0126274032810095 0.0625710471344843 0.828472755180353 0.708333333333333 11.4 11 4 hypopigmentation 0.0126274032810095 0.0625710471344843 0.828472755180353 0.708333333333333 11.4 11 4 abnormal inner cell mass apoptosis 0.0126274032810095 0.0625710471344843 0.828472755180353 0.708333333333333 11.4 11 4 abnormal lung saccule morphology 0.0126274032810095 0.0625710471344843 0.828472755180353 0.708333333333333 11.4 11 4 impaired coordination 7.78565882128351e-21 1.38334473699591e-18 0.828191057541733 0.708092485549133 11.4 11 4 increased startle reflex 2.05528368683821e-06 3.63880296869042e-05 0.827925185613149 0.707865168539326 11.4 11 4 abnormal muscle physiology 2.05528368683821e-06 3.63880296869042e-05 0.827925185613149 0.707865168539326 11.4 11 4 short humerus 0.00123168509687395 0.00969562240023402 0.827284128558861 0.707317073170732 11.4 11 4 abnormal spleen morphology 4.07356826777247e-11 1.82576595785297e-09 0.826792283060312 0.706896551724138 11.4 11 4 glomerulosclerosis 0.000129700032730343 0.00142440985172949 0.826792283060312 0.706896551724138 11.4 11 4 abnormal vertebrae morphology 1.79144549093431e-07 4.01461320603522e-06 0.826237264745436 0.706422018348624 11.4 11 4 overexpanded pulmonary alveoli 0.00337519563089755 0.0219211465583751 0.825606067446165 0.705882352941177 11.4 11 4 abnormal adipose tissue morphology 0.0368546236938845 0.142464454449942 0.825606067446165 0.705882352941177 11.4 11 4 hyperlipidemia 0.0368546236938845 0.142464454449942 0.825606067446165 0.705882352941177 11.4 11 4 nephrocalcinosis 0.0368546236938845 0.142464454449942 0.825606067446165 0.705882352941177 11.4 11 4 abnormal duodenum morphology 0.0368546236938845 0.142464454449942 0.825606067446165 0.705882352941177 11.4 11 4 abnormal melanosome morphology 0.0368546236938845 0.142464454449942 0.825606067446165 0.705882352941177 11.4 11 4 abnormal tarsal bone morphology 0.0368546236938845 0.142464454449942 0.825606067446165 0.705882352941177 11.4 11 4 enhanced behavioral response to cocaine 0.0368546236938845 0.142464454449942 0.825606067446165 0.705882352941177 11.4 11 4 increased circulating magnesium level 0.0368546236938845 0.142464454449942 0.825606067446165 0.705882352941177 11.4 11 4 decreased body fat mass 0.0368546236938845 0.142464454449942 0.825606067446165 0.705882352941177 11.4 11 4 abnormal heart morphology 3.83922168431433e-14 2.65279553881442e-12 0.825308229759496 0.705627705627706 11.4 11 4 decreased blood urea nitrogen level 0.000934484430777071 0.00757252395803997 0.824042419591153 0.704545454545455 11.4 11 4 abnormal nervous system physiology 1.06459636000531e-07 2.54633023607038e-06 0.823811271647369 0.704347826086957 11.4 11 4 atelectasis 2.86619344791712e-05 0.000384348043217997 0.82366802503432 0.704225352112676 11.4 11 4 increased circulating free fatty acid level 2.86619344791712e-05 0.000384348043217997 0.82366802503432 0.704225352112676 11.4 11 4 cardiac hypertrophy 9.37246725608223e-07 1.80030983007757e-05 0.823499929519006 0.704081632653061 11.4 11 4 abnormal small intestine morphology 0.000264266147687677 0.00266830133989958 0.823057900571331 0.703703703703704 11.4 11 4 rectal prolapse 0.00941381502340593 0.0509678765261588 0.823057900571331 0.703703703703704 11.4 11 4 wrinkled skin 0.00941381502340593 0.0509678765261588 0.823057900571331 0.703703703703704 11.4 11 4 abnormal brain commissure morphology 0.00941381502340593 0.0509678765261588 0.823057900571331 0.703703703703704 11.4 11 4 abnormal bone trabecula morphology 0.00941381502340593 0.0509678765261588 0.823057900571331 0.703703703703704 11.4 11 4 increased circulating triglyceride level 2.80368635386757e-09 9.36130175200748e-08 0.822759149972213 0.703448275862069 11.4 11 4 abnormal osteoclast physiology 7.57932468753219e-05 0.000913005818897642 0.822381043745203 0.703125 11.4 11 4 abnormal tooth morphology 7.57932468753219e-05 0.000913005818897642 0.822381043745203 0.703125 11.4 11 4 abnormal branching of the mammary ductal tree 0.00254497094864875 0.0173530289574693 0.821887121196407 0.702702702702703 11.4 11 4 abnormal hair follicle development 0.00254497094864875 0.0173530289574693 0.821887121196407 0.702702702702703 11.4 11 4 abnormal calcium ion homeostasis 0.00254497094864875 0.0173530289574693 0.821887121196407 0.702702702702703 11.4 11 4 cleft secondary palate 1.88062986534305e-06 3.42715515753908e-05 0.821214545810813 0.702127659574468 11.4 11 4 abnormal eating behavior 0.000153494484556101 0.00165647518582778 0.818726016884114 0.7 11.4 11 4 abnormal hindlimb morphology 0.000538409579145942 0.00490583819826202 0.818726016884114 0.7 11.4 11 4 abnormal hair cycle 0.00703403073737605 0.0395415852185829 0.818726016884114 0.7 11.4 11 4 emphysema 0.00703403073737605 0.0395415852185829 0.818726016884114 0.7 11.4 11 4 liver hemorrhage 0.00703403073737605 0.0395415852185829 0.818726016884114 0.7 11.4 11 4 abnormal vascular regression 0.0269886190052283 0.111426041121171 0.818726016884114 0.7 11.4 11 4 increased urine glucose level 0.0269886190052283 0.111426041121171 0.818726016884114 0.7 11.4 11 4 abnormal hair texture 0.0269886190052283 0.111426041121171 0.818726016884114 0.7 11.4 11 4 abnormal trachea morphology 0.0269886190052283 0.111426041121171 0.818726016884114 0.7 11.4 11 4 spleen atrophy 0.0269886190052283 0.111426041121171 0.818726016884114 0.7 11.4 11 4 abnormal physiological neovascularization 0.0269886190052283 0.111426041121171 0.818726016884114 0.7 11.4 11 4 decreased circulating VLDL cholesterol level 0.0269886190052283 0.111426041121171 0.818726016884114 0.7 11.4 11 4 jaundice 0.115174362692941 0.304297639085175 0.818726016884114 0.7 11.4 11 4 enlarged testis 0.115174362692941 0.304297639085175 0.818726016884114 0.7 11.4 11 4 absent trophoblast giant cells 0.115174362692941 0.304297639085175 0.818726016884114 0.7 11.4 11 4 abnormal neuron specification 0.115174362692941 0.304297639085175 0.818726016884114 0.7 11.4 11 4 abnormal primordial germ cell migration 0.115174362692941 0.304297639085175 0.818726016884114 0.7 11.4 11 4 abnormal hypaxial muscle morphology 0.115174362692941 0.304297639085175 0.818726016884114 0.7 11.4 11 4 abnormal submandibular gland morphology 0.115174362692941 0.304297639085175 0.818726016884114 0.7 11.4 11 4 increased atrioventricular cushion size 0.115174362692941 0.304297639085175 0.818726016884114 0.7 11.4 11 4 absent pharyngeal arches 0.115174362692941 0.304297639085175 0.818726016884114 0.7 11.4 11 4 abnormal ear physiology 0.115174362692941 0.304297639085175 0.818726016884114 0.7 11.4 11 4 abnormal reproductive system development 0.115174362692941 0.304297639085175 0.818726016884114 0.7 11.4 11 4 abnormal placental transport 0.115174362692941 0.304297639085175 0.818726016884114 0.7 11.4 11 4 decreased cochlear inner hair cell number 0.115174362692941 0.304297639085175 0.818726016884114 0.7 11.4 11 4 increased susceptibility to atherosclerosis 0.115174362692941 0.304297639085175 0.818726016884114 0.7 11.4 11 4 increased serotonin level 0.115174362692941 0.304297639085175 0.818726016884114 0.7 11.4 11 4 increased kidney iron level 0.115174362692941 0.304297639085175 0.818726016884114 0.7 11.4 11 4 abnormal heart and great artery attachment 0.115174362692941 0.304297639085175 0.818726016884114 0.7 11.4 11 4 thick aortic valve 0.115174362692941 0.304297639085175 0.818726016884114 0.7 11.4 11 4 abnormal pulmonary interalveolar septum morphology 0.115174362692941 0.304297639085175 0.818726016884114 0.7 11.4 11 4 decreased trabecular bone connectivity density 0.115174362692941 0.304297639085175 0.818726016884114 0.7 11.4 11 4 abnormal circadian temperature homeostasis 0.115174362692941 0.304297639085175 0.818726016884114 0.7 11.4 11 4 decreased macrophage cytokine production 0.115174362692941 0.304297639085175 0.818726016884114 0.7 11.4 11 4 decreased macrophage apoptosis 0.115174362692941 0.304297639085175 0.818726016884114 0.7 11.4 11 4 increased bone mineral density 2.51786157394503e-07 5.47002678182381e-06 0.817690965029646 0.699115044247788 11.4 11 4 seminiferous tubule degeneration 3.38347015766866e-05 0.000442967474589516 0.817123813328568 0.698630136986301 11.4 11 4 reduced female fertility 1.95084526119257e-13 1.26044872395234e-11 0.816709450340064 0.698275862068966 11.4 11 4 abnormal coat/ hair morphology 0.000408892636861668 0.00382376103080225 0.816519208213267 0.69811320754717 11.4 11 4 azoospermia 1.16909363585203e-09 4.15445774168847e-08 0.816519208213267 0.69811320754717 11.4 11 4 decreased oxygen consumption 0.00145073097545621 0.0109644611596056 0.816005996894465 0.697674418604651 11.4 11 4 impaired glucose tolerance 3.47899496083767e-14 2.43774646903766e-12 0.815896318669076 0.69758064516129 11.4 11 4 insulin resistance 3.39295784238848e-08 9.27470619004543e-07 0.815181748412754 0.696969696969697 11.4 11 4 belly spot 0.00526646908959499 0.0315417425317434 0.815181748412754 0.696969696969697 11.4 11 4 abnormal epidermis stratum basale morphology 0.00526646908959499 0.0315417425317434 0.815181748412754 0.696969696969697 11.4 11 4 increased osteoblast cell number 0.00526646908959499 0.0315417425317434 0.815181748412754 0.696969696969697 11.4 11 4 head tossing 0.00526646908959499 0.0315417425317434 0.815181748412754 0.696969696969697 11.4 11 4 abnormal neuron differentiation 3.85144424283405e-07 7.95838172474681e-06 0.814548843328582 0.696428571428571 11.4 11 4 abnormal eye development 0.000310644736495013 0.00307248024664551 0.814548843328582 0.696428571428571 11.4 11 4 abnormal testis morphology 2.95560009972349e-07 6.31077703696324e-06 0.813640762120858 0.695652173913043 11.4 11 4 fragile skeleton 0.0198742702191304 0.0901101645011464 0.813640762120858 0.695652173913043 11.4 11 4 failure of embryo implantation 0.0198742702191304 0.0901101645011464 0.813640762120858 0.695652173913043 11.4 11 4 conjunctivitis 0.0198742702191304 0.0901101645011464 0.813640762120858 0.695652173913043 11.4 11 4 abnormal cochlear ganglion morphology 0.0198742702191304 0.0901101645011464 0.813640762120858 0.695652173913043 11.4 11 4 abnormal hepatocyte physiology 0.0198742702191304 0.0901101645011464 0.813640762120858 0.695652173913043 11.4 11 4 head tilt 0.00395015563295796 0.0248445313198051 0.812228191353287 0.694444444444444 11.4 11 4 postnatal lethality, complete penetrance 1.04855489945705e-20 1.79881400855131e-18 0.812059853904302 0.694300518134715 11.4 11 4 circling 1.15441956782695e-05 0.000169417030971654 0.811845966322062 0.694117647058824 11.4 11 4 increased circulating LDL cholesterol level 0.000829659832252221 0.00689074735468247 0.811565147931774 0.693877551020408 11.4 11 4 increased sarcoma incidence 0.000829659832252221 0.00689074735468247 0.811565147931774 0.693877551020408 11.4 11 4 abnormal neurocranium morphology 3.95521353485232e-05 0.000515109616122783 0.810928626247122 0.693333333333333 11.4 11 4 increased circulating cholesterol level 3.68825869009024e-10 1.44480999867708e-08 0.810751412823554 0.693181818181818 11.4 11 4 abnormal pulmonary alveolus morphology 1.98603146865668e-06 3.54140019948638e-05 0.810619818697142 0.693069306930693 11.4 11 4 decreased startle reflex 3.44833371595596e-07 7.23859081724932e-06 0.809729027687585 0.692307692307692 11.4 11 4 decreased cardiac muscle contractility 1.52047663727711e-06 2.7912809116065e-05 0.809729027687585 0.692307692307692 11.4 11 4 abnormal heart ventricle morphology 3.01713476523163e-05 0.000402419449250063 0.809729027687585 0.692307692307692 11.4 11 4 abnormal skin condition 0.000628111094950745 0.00565072820502704 0.809729027687585 0.692307692307692 11.4 11 4 abnormal hair growth 0.000628111094950745 0.00565072820502704 0.809729027687585 0.692307692307692 11.4 11 4 acanthosis 0.00296758937590571 0.0194004693102903 0.809729027687585 0.692307692307692 11.4 11 4 decreased trabecular bone volume 0.00296758937590571 0.0194004693102903 0.809729027687585 0.692307692307692 11.4 11 4 absent teeth 0.0812454400488708 0.246611387579702 0.809729027687585 0.692307692307692 11.4 11 4 absent myocardial trabeculae 0.0812454400488708 0.246611387579702 0.809729027687585 0.692307692307692 11.4 11 4 absent trabeculae carneae 0.0812454400488708 0.246611387579702 0.809729027687585 0.692307692307692 11.4 11 4 uterus hypoplasia 0.0812454400488708 0.246611387579702 0.809729027687585 0.692307692307692 11.4 11 4 tight skin 0.0812454400488708 0.246611387579702 0.809729027687585 0.692307692307692 11.4 11 4 excessive scratching 0.0812454400488708 0.246611387579702 0.809729027687585 0.692307692307692 11.4 11 4 abnormal pulmonary alveolus epithelial cell morphology 0.0812454400488708 0.246611387579702 0.809729027687585 0.692307692307692 11.4 11 4 anal atresia 0.0812454400488708 0.246611387579702 0.809729027687585 0.692307692307692 11.4 11 4 abnormal vestibulocochlear ganglion morphology 0.0812454400488708 0.246611387579702 0.809729027687585 0.692307692307692 11.4 11 4 small otic vesicle 0.0812454400488708 0.246611387579702 0.809729027687585 0.692307692307692 11.4 11 4 increased circulating thyroxine level 0.0812454400488708 0.246611387579702 0.809729027687585 0.692307692307692 11.4 11 4 increased prostaglandin level 0.0812454400488708 0.246611387579702 0.809729027687585 0.692307692307692 11.4 11 4 abnormal aorta tunica media morphology 0.0812454400488708 0.246611387579702 0.809729027687585 0.692307692307692 11.4 11 4 decreased cardiac stroke volume 0.0812454400488708 0.246611387579702 0.809729027687585 0.692307692307692 11.4 11 4 weight loss 5.5874579335904e-10 2.13574723987699e-08 0.808700800350839 0.691428571428571 11.4 11 4 abnormal learning/memory/conditioning 0.000475845967847374 0.00438395127785312 0.808093211470034 0.690909090909091 11.4 11 4 neonatal lethality, complete penetrance 1.62265997991271e-23 3.22909336002628e-21 0.807953306135638 0.690789473684211 11.4 11 4 abnormal vibrissa morphology 0.00223262293420491 0.01568827556168 0.807586887402697 0.69047619047619 11.4 11 4 increased leukocyte cell number 2.08595632591792e-08 5.9300758408238e-07 0.806626617619816 0.689655172413793 11.4 11 4 abnormal enzyme/coenzyme level 0.000360720661829196 0.00348201058372784 0.806626617619816 0.689655172413793 11.4 11 4 aphagia 0.0109140783396839 0.0552134077635748 0.806626617619816 0.689655172413793 11.4 11 4 abnormal motor capabilities/coordination/movement 9.1187163142024e-08 2.21295676405643e-06 0.806321077234354 0.689393939393939 11.4 11 4 abnormal ovarian follicle morphology 0.00168184468831534 0.0125257145574384 0.805730365822461 0.688888888888889 11.4 11 4 cardiomyopathy 0.00168184468831534 0.0125257145574384 0.805730365822461 0.688888888888889 11.4 11 4 lethality at weaning, complete penetrance 0.00168184468831534 0.0125257145574384 0.805730365822461 0.688888888888889 11.4 11 4 thymus hypoplasia 5.3559934954176e-08 1.41734402338843e-06 0.805165337515433 0.688405797101449 11.4 11 4 curly tail 0.00126841307961981 0.00996896535720151 0.804105909439754 0.6875 11.4 11 4 increased circulating follicle stimulating hormone level 0.00812760463256235 0.0449275922744419 0.804105909439754 0.6875 11.4 11 4 absent mandible 0.0582292918381281 0.192357720381598 0.804105909439754 0.6875 11.4 11 4 decreased mast cell number 0.0582292918381281 0.192357720381598 0.804105909439754 0.6875 11.4 11 4 mixed cellular infiltration to dermis 0.0582292918381281 0.192357720381598 0.804105909439754 0.6875 11.4 11 4 poor circulation 0.0582292918381281 0.192357720381598 0.804105909439754 0.6875 11.4 11 4 white spotting 0.0582292918381281 0.192357720381598 0.804105909439754 0.6875 11.4 11 4 abnormal epicardium morphology 0.0582292918381281 0.192357720381598 0.804105909439754 0.6875 11.4 11 4 large intestinal inflammation 0.0582292918381281 0.192357720381598 0.804105909439754 0.6875 11.4 11 4 increased pancreatic beta cell number 0.0582292918381281 0.192357720381598 0.804105909439754 0.6875 11.4 11 4 decreased aggression towards mice 0.0582292918381281 0.192357720381598 0.804105909439754 0.6875 11.4 11 4 small pancreas 0.0582292918381281 0.192357720381598 0.804105909439754 0.6875 11.4 11 4 kidney degeneration 0.0582292918381281 0.192357720381598 0.804105909439754 0.6875 11.4 11 4 decreased liver cholesterol level 0.0582292918381281 0.192357720381598 0.804105909439754 0.6875 11.4 11 4 decreased midbrain size 0.0582292918381281 0.192357720381598 0.804105909439754 0.6875 11.4 11 4 decreased fibroblast apoptosis 0.0582292918381281 0.192357720381598 0.804105909439754 0.6875 11.4 11 4 decreased adipocyte glucose uptake 0.0582292918381281 0.192357720381598 0.804105909439754 0.6875 11.4 11 4 reduced male fertility 4.16834700604159e-12 2.25407895163662e-10 0.80378388064142 0.687224669603524 11.4 11 4 impaired balance 3.47981708621787e-06 5.77069666797797e-05 0.80267256557266 0.686274509803922 11.4 11 4 distended abdomen 0.000957618121184459 0.00770898082992343 0.80267256557266 0.686274509803922 11.4 11 4 impaired hematopoiesis 0.000957618121184459 0.00770898082992343 0.80267256557266 0.686274509803922 11.4 11 4 abnormal artery morphology 0.00606831343277493 0.0353097769918775 0.802017322661989 0.685714285714286 11.4 11 4 abnormal hippocampus pyramidal cell morphology 0.00606831343277493 0.0353097769918775 0.802017322661989 0.685714285714286 11.4 11 4 decreased bone mineral density 1.33779227475251e-13 8.75725864064964e-12 0.80025851274387 0.684210526315789 11.4 11 4 seizures 1.18595787662381e-06 2.22646808913338e-05 0.80025851274387 0.684210526315789 11.4 11 4 abnormal reproductive system physiology 0.0045409293544036 0.0278902759730345 0.80025851274387 0.684210526315789 11.4 11 4 thin dermal layer 0.0421907632038025 0.1538849317734 0.80025851274387 0.684210526315789 11.4 11 4 abnormal nasal septum morphology 0.0421907632038025 0.1538849317734 0.80025851274387 0.684210526315789 11.4 11 4 abnormal photoreceptor inner segment morphology 0.0421907632038025 0.1538849317734 0.80025851274387 0.684210526315789 11.4 11 4 increased left ventricle weight 0.0421907632038025 0.1538849317734 0.80025851274387 0.684210526315789 11.4 11 4 increased circulating VLDL cholesterol level 0.0421907632038025 0.1538849317734 0.80025851274387 0.684210526315789 11.4 11 4 increased liver cholesterol level 0.0421907632038025 0.1538849317734 0.80025851274387 0.684210526315789 11.4 11 4 decreased liver glycogen level 0.0421907632038025 0.1538849317734 0.80025851274387 0.684210526315789 11.4 11 4 shortened RR interval 0.0421907632038025 0.1538849317734 0.80025851274387 0.684210526315789 11.4 11 4 thin interventricular septum 0.0421907632038025 0.1538849317734 0.80025851274387 0.684210526315789 11.4 11 4 male infertility 2.38831832147736e-24 5.40085620424995e-22 0.799891365544263 0.68389662027833 11.4 11 4 liver inflammation 6.92867900123243e-07 1.36245762968899e-05 0.799232540291635 0.683333333333333 11.4 11 4 abnormal mammary gland development 0.00340459493428331 0.0220258254851228 0.798757089643038 0.682926829268293 11.4 11 4 Leydig cell hyperplasia 0.00340459493428331 0.0220258254851228 0.798757089643038 0.682926829268293 11.4 11 4 short ulna 0.00340459493428331 0.0220258254851228 0.798757089643038 0.682926829268293 11.4 11 4 abnormal myelopoiesis 0.00255697357119722 0.0173783381375767 0.797460406055955 0.681818181818182 11.4 11 4 decreased sensitivity to induced morbidity/mortality 0.00255697357119722 0.0173783381375767 0.797460406055955 0.681818181818182 11.4 11 4 abnormal occipital bone morphology 0.0308149954332591 0.125695884964875 0.797460406055955 0.681818181818182 11.4 11 4 abnormal sperm midpiece morphology 0.0308149954332591 0.125695884964875 0.797460406055955 0.681818181818182 11.4 11 4 rough coat 0.0308149954332591 0.125695884964875 0.797460406055955 0.681818181818182 11.4 11 4 small testis 1.03265279677493e-13 6.84993021860704e-12 0.796689912910007 0.681159420289855 11.4 11 4 decreased bone trabecula number 0.00192327423335471 0.0141125211075806 0.796329256543819 0.680851063829787 11.4 11 4 spleen hyperplasia 0.000103994654331282 0.00119010389829986 0.795333844973139 0.68 11.4 11 4 decreased oocyte number 0.00144856662010305 0.0109644611596056 0.795333844973139 0.68 11.4 11 4 abnormal cochlear outer hair cell morphology 0.0226447538627306 0.0962063624825661 0.795333844973139 0.68 11.4 11 4 decreased placenta weight 0.0226447538627306 0.0962063624825661 0.795333844973139 0.68 11.4 11 4 abnormal energy expenditure 0.0226447538627306 0.0962063624825661 0.795333844973139 0.68 11.4 11 4 hydronephrosis 4.56625136456694e-05 0.000579517870885728 0.793662975550926 0.678571428571429 11.4 11 4 short mandible 0.000824604122924583 0.00687170102437152 0.793662975550926 0.678571428571429 11.4 11 4 abnormal jaw morphology 0.0167218171866178 0.079761304413637 0.793662975550926 0.678571428571429 11.4 11 4 small superior cervical ganglion 0.0167218171866178 0.079761304413637 0.793662975550926 0.678571428571429 11.4 11 4 abnormal ovulation 0.0167218171866178 0.079761304413637 0.793662975550926 0.678571428571429 11.4 11 4 corneal vascularization 0.0167218171866178 0.079761304413637 0.793662975550926 0.678571428571429 11.4 11 4 improved glucose tolerance 5.80485475932074e-10 2.17136484418201e-08 0.793662975550926 0.678571428571429 11.4 11 4 abnormal object recognition memory 0.0123969997015855 0.0620473576613561 0.792315500210433 0.67741935483871 11.4 11 4 small cranium 0.0123969997015855 0.0620473576613561 0.792315500210433 0.67741935483871 11.4 11 4 abnormal intestine physiology 0.0123969997015855 0.0620473576613561 0.792315500210433 0.67741935483871 11.4 11 4 female infertility 8.55018405587593e-13 5.00437243270385e-11 0.791464463153278 0.676691729323308 11.4 11 4 abnormal retina morphology 2.26753075951399e-10 9.32311200709263e-09 0.790878193180572 0.676190476190476 11.4 11 4 abnormal long bone metaphysis morphology 0.00687762372526874 0.0388820204922863 0.790276078073469 0.675675675675676 11.4 11 4 abnormal vocalization 0.00687762372526874 0.0388820204922863 0.790276078073469 0.675675675675676 11.4 11 4 decreased circulating chloride level 0.00687762372526874 0.0388820204922863 0.790276078073469 0.675675675675676 11.4 11 4 increased trabecular bone volume 0.00687762372526874 0.0388820204922863 0.790276078073469 0.675675675675676 11.4 11 4 respiratory failure 8.00063916513052e-08 2.01026160841032e-06 0.790066733417025 0.675496688741722 11.4 11 4 polyuria 0.000117894186637933 0.00130338573005271 0.789865545045898 0.675324675324675 11.4 11 4 abnormal pancreatic beta cell morphology 0.00514198840772088 0.0312349112679016 0.789485801995395 0.675 11.4 11 4 organ of Corti degeneration 0.00217334165231548 0.0153149783573222 0.78769558475731 0.673469387755102 11.4 11 4 increased T cell derived lymphoma incidence 0.00217334165231548 0.0153149783573222 0.78769558475731 0.673469387755102 11.4 11 4 increased susceptibility to injury 0.00163601493990094 0.0122577926596494 0.787236554696263 0.673076923076923 11.4 11 4 abnormal long bone morphology 0.000702780734799598 0.00605950460247487 0.786130367499969 0.672131147540984 11.4 11 4 increased osteoclast cell number 0.000702780734799598 0.00605950460247487 0.786130367499969 0.672131147540984 11.4 11 4 abnormal lens morphology 1.14950325351585e-06 2.17832313751459e-05 0.785830775134305 0.671875 11.4 11 4 decreased compact bone thickness 0.000402029548120378 0.00377864457906764 0.785558011935717 0.671641791044776 11.4 11 4 abnormal femur morphology 0.000402029548120378 0.00377864457906764 0.785558011935717 0.671641791044776 11.4 11 4 increased T cell number 5.81533264785426e-05 0.000718586293139903 0.784169399288356 0.670454545454545 11.4 11 4 increased circulating insulin level 8.72309502282707e-08 2.13780284426427e-06 0.782175748273216 0.66875 11.4 11 4 abnormal synaptic transmission 0.0186741735442995 0.0857839458752447 0.779739063699156 0.666666666666667 11.4 11 4 abnormal cellular respiration 0.0186741735442995 0.0857839458752447 0.779739063699156 0.666666666666667 11.4 11 4 abnormal fontanelle morphology 0.090117229897233 0.26790677039786 0.779739063699156 0.666666666666667 11.4 11 4 decreased chondrocyte number 0.090117229897233 0.26790677039786 0.779739063699156 0.666666666666667 11.4 11 4 hyperpigmentation 0.090117229897233 0.26790677039786 0.779739063699156 0.666666666666667 11.4 11 4 no suckling reflex 0.090117229897233 0.26790677039786 0.779739063699156 0.666666666666667 11.4 11 4 absent egg cylinders 0.090117229897233 0.26790677039786 0.779739063699156 0.666666666666667 11.4 11 4 altered righting response 0.090117229897233 0.26790677039786 0.779739063699156 0.666666666666667 11.4 11 4 abnormal pericyte morphology 0.090117229897233 0.26790677039786 0.779739063699156 0.666666666666667 11.4 11 4 absent chorion 0.090117229897233 0.26790677039786 0.779739063699156 0.666666666666667 11.4 11 4 abnormal aorta wall morphology 0.090117229897233 0.26790677039786 0.779739063699156 0.666666666666667 11.4 11 4 ostium primum atrial septal defect 0.090117229897233 0.26790677039786 0.779739063699156 0.666666666666667 11.4 11 4 herniated liver 0.090117229897233 0.26790677039786 0.779739063699156 0.666666666666667 11.4 11 4 hyperkeratosis 0.000449687070133099 0.00417386786177643 0.779739063699156 0.666666666666667 11.4 11 4 increased lymphocyte cell number 0.000449687070133099 0.00417386786177643 0.779739063699156 0.666666666666667 11.4 11 4 impaired swimming 0.000594294843049728 0.00539528621199342 0.779739063699156 0.666666666666667 11.4 11 4 absent vitelline blood vessels 0.00137911209446518 0.0105287711704124 0.779739063699156 0.666666666666667 11.4 11 4 abnormal response to novel object 0.00243046361794021 0.0168640955359171 0.779739063699156 0.666666666666667 11.4 11 4 oligodactyly 0.0032329965408245 0.0210250428635319 0.779739063699156 0.666666666666667 11.4 11 4 skin edema 0.00574853893444009 0.0336854902224258 0.779739063699156 0.666666666666667 11.4 11 4 small lens 0.00768760931139938 0.0429728722743954 0.779739063699156 0.666666666666667 11.4 11 4 impaired wound healing 0.0103046290324089 0.0540205789633659 0.779739063699156 0.666666666666667 11.4 11 4 renal hypoplasia 0.0103046290324089 0.0540205789633659 0.779739063699156 0.666666666666667 11.4 11 4 dextrocardia 0.0138498757184971 0.0683562814479395 0.779739063699156 0.666666666666667 11.4 11 4 single kidney 0.0138498757184971 0.0683562814479395 0.779739063699156 0.666666666666667 11.4 11 4 abnormal foregut morphology 0.0343680040953723 0.134207865286089 0.779739063699156 0.666666666666667 11.4 11 4 abnormal adrenal gland morphology 0.0343680040953723 0.134207865286089 0.779739063699156 0.666666666666667 11.4 11 4 abnormal vasodilation 0.0343680040953723 0.134207865286089 0.779739063699156 0.666666666666667 11.4 11 4 abnormal tumor morphology 0.0343680040953723 0.134207865286089 0.779739063699156 0.666666666666667 11.4 11 4 small ears 0.0470033748548816 0.162615987415185 0.779739063699156 0.666666666666667 11.4 11 4 abnormal salivary gland morphology 0.0470033748548816 0.162615987415185 0.779739063699156 0.666666666666667 11.4 11 4 abnormal anxiety-related response 0.0470033748548816 0.162615987415185 0.779739063699156 0.666666666666667 11.4 11 4 abnormal embryonic/fetal subventricular zone morphology 0.0470033748548816 0.162615987415185 0.779739063699156 0.666666666666667 11.4 11 4 abnormal tumor vascularization 0.0470033748548816 0.162615987415185 0.779739063699156 0.666666666666667 11.4 11 4 abnormal heart shape 0.0647625592520027 0.211274578543419 0.779739063699156 0.666666666666667 11.4 11 4 thick dermal layer 0.0647625592520027 0.211274578543419 0.779739063699156 0.666666666666667 11.4 11 4 abnormal thymus cortex morphology 0.0647625592520027 0.211274578543419 0.779739063699156 0.666666666666667 11.4 11 4 abnormal white adipose tissue morphology 0.0647625592520027 0.211274578543419 0.779739063699156 0.666666666666667 11.4 11 4 absent ureter 0.0647625592520027 0.211274578543419 0.779739063699156 0.666666666666667 11.4 11 4 abnormal neutrophil morphology 0.0647625592520027 0.211274578543419 0.779739063699156 0.666666666666667 11.4 11 4 decreased pulmonary respiratory rate 0.0647625592520027 0.211274578543419 0.779739063699156 0.666666666666667 11.4 11 4 abnormal pregnancy 0.0647625592520027 0.211274578543419 0.779739063699156 0.666666666666667 11.4 11 4 increased gastrointestinal tumor incidence 0.0647625592520027 0.211274578543419 0.779739063699156 0.666666666666667 11.4 11 4 decreased tumor latency 0.0647625592520027 0.211274578543419 0.779739063699156 0.666666666666667 11.4 11 4 atrioventricular block 0.0647625592520027 0.211274578543419 0.779739063699156 0.666666666666667 11.4 11 4 abnormal metanephric mesenchyme morphology 0.0647625592520027 0.211274578543419 0.779739063699156 0.666666666666667 11.4 11 4 amyloidosis 0.127147608191556 0.331877938485306 0.779739063699156 0.666666666666667 11.4 11 4 abnormal superior cervical ganglion morphology 0.127147608191556 0.331877938485306 0.779739063699156 0.666666666666667 11.4 11 4 abnormal enteric nervous system morphology 0.127147608191556 0.331877938485306 0.779739063699156 0.666666666666667 11.4 11 4 absent optic nerve 0.127147608191556 0.331877938485306 0.779739063699156 0.666666666666667 11.4 11 4 interstitial pneumonia 0.127147608191556 0.331877938485306 0.779739063699156 0.666666666666667 11.4 11 4 abnormal tracheal ciliated epithelium morphology 0.127147608191556 0.331877938485306 0.779739063699156 0.666666666666667 11.4 11 4 decreased synaptic depression 0.127147608191556 0.331877938485306 0.779739063699156 0.666666666666667 11.4 11 4 small intestinal inflammation 0.127147608191556 0.331877938485306 0.779739063699156 0.666666666666667 11.4 11 4 abnormal nucleotide metabolism 0.127147608191556 0.331877938485306 0.779739063699156 0.666666666666667 11.4 11 4 decreased left ventricle systolic pressure 0.127147608191556 0.331877938485306 0.779739063699156 0.666666666666667 11.4 11 4 abnormal defecation 0.127147608191556 0.331877938485306 0.779739063699156 0.666666666666667 11.4 11 4 vestibular saccular macula degeneration 0.127147608191556 0.331877938485306 0.779739063699156 0.666666666666667 11.4 11 4 bowed ulna 0.127147608191556 0.331877938485306 0.779739063699156 0.666666666666667 11.4 11 4 decreased cochlear nerve compound action potential 0.127147608191556 0.331877938485306 0.779739063699156 0.666666666666667 11.4 11 4 reduced cerebellar foliation 0.127147608191556 0.331877938485306 0.779739063699156 0.666666666666667 11.4 11 4 increased fibrosarcoma incidence 0.127147608191556 0.331877938485306 0.779739063699156 0.666666666666667 11.4 11 4 persistent right dorsal aorta 0.127147608191556 0.331877938485306 0.779739063699156 0.666666666666667 11.4 11 4 abnormal colon goblet cell morphology 0.127147608191556 0.331877938485306 0.779739063699156 0.666666666666667 11.4 11 4 crypts of Lieberkuhn abscesses 0.1831956010318 0.427284629692079 0.779739063699156 0.666666666666667 11.4 11 4 renal tubular acidosis 0.1831956010318 0.427284629692079 0.779739063699156 0.666666666666667 11.4 11 4 thick tail 0.1831956010318 0.427284629692079 0.779739063699156 0.666666666666667 11.4 11 4 absent parathyroid glands 0.1831956010318 0.427284629692079 0.779739063699156 0.666666666666667 11.4 11 4 abnormal vagina epithelium morphology 0.1831956010318 0.427284629692079 0.779739063699156 0.666666666666667 11.4 11 4 psoriasis 0.1831956010318 0.427284629692079 0.779739063699156 0.666666666666667 11.4 11 4 wavy vibrissae 0.1831956010318 0.427284629692079 0.779739063699156 0.666666666666667 11.4 11 4 abnormal lens vesicle development 0.1831956010318 0.427284629692079 0.779739063699156 0.666666666666667 11.4 11 4 abnormal germ cell morphology 0.1831956010318 0.427284629692079 0.779739063699156 0.666666666666667 11.4 11 4 abnormal vomeronasal organ morphology 0.1831956010318 0.427284629692079 0.779739063699156 0.666666666666667 11.4 11 4 long gestation period 0.1831956010318 0.427284629692079 0.779739063699156 0.666666666666667 11.4 11 4 abnormal gut-associated lymphoid tissue morphology 0.1831956010318 0.427284629692079 0.779739063699156 0.666666666666667 11.4 11 4 abnormal abdominal wall morphology 0.1831956010318 0.427284629692079 0.779739063699156 0.666666666666667 11.4 11 4 abnormal ovary physiology 0.1831956010318 0.427284629692079 0.779739063699156 0.666666666666667 11.4 11 4 abnormal stria vascularis vasculature morphology 0.1831956010318 0.427284629692079 0.779739063699156 0.666666666666667 11.4 11 4 decreased cochlear hair cell number 0.1831956010318 0.427284629692079 0.779739063699156 0.666666666666667 11.4 11 4 abnormal hair cell mechanoelectric transduction 0.1831956010318 0.427284629692079 0.779739063699156 0.666666666666667 11.4 11 4 decreased thyroid-stimulating hormone level 0.1831956010318 0.427284629692079 0.779739063699156 0.666666666666667 11.4 11 4 abnormal intervertebral disk development 0.1831956010318 0.427284629692079 0.779739063699156 0.666666666666667 11.4 11 4 abnormal leukopoiesis 0.1831956010318 0.427284629692079 0.779739063699156 0.666666666666667 11.4 11 4 decreased pulmonary ventilation 0.1831956010318 0.427284629692079 0.779739063699156 0.666666666666667 11.4 11 4 increased tidal volume 0.1831956010318 0.427284629692079 0.779739063699156 0.666666666666667 11.4 11 4 enhanced conditioned place preference behavior 0.1831956010318 0.427284629692079 0.779739063699156 0.666666666666667 11.4 11 4 abnormal retinal development 0.1831956010318 0.427284629692079 0.779739063699156 0.666666666666667 11.4 11 4 abnormal hippocampus granule cell morphology 0.1831956010318 0.427284629692079 0.779739063699156 0.666666666666667 11.4 11 4 abnormal ventricle myocardium morphology 0.1831956010318 0.427284629692079 0.779739063699156 0.666666666666667 11.4 11 4 fusion of atlas and occipital bones 0.1831956010318 0.427284629692079 0.779739063699156 0.666666666666667 11.4 11 4 abnormal pulmonary alveolar parenchyma morphology 0.1831956010318 0.427284629692079 0.779739063699156 0.666666666666667 11.4 11 4 decreased airway resistance 0.1831956010318 0.427284629692079 0.779739063699156 0.666666666666667 11.4 11 4 reduced AMPA-mediated synaptic currents 0.1831956010318 0.427284629692079 0.779739063699156 0.666666666666667 11.4 11 4 increased core body temperature 0.1831956010318 0.427284629692079 0.779739063699156 0.666666666666667 11.4 11 4 decreased pancreatic beta cell proliferation 0.1831956010318 0.427284629692079 0.779739063699156 0.666666666666667 11.4 11 4 increased myeloid cell number 0.1831956010318 0.427284629692079 0.779739063699156 0.666666666666667 11.4 11 4 abnormal ductus venosus valve topology 0.1831956010318 0.427284629692079 0.779739063699156 0.666666666666667 11.4 11 4 decreased bone mineral density of femur 0.1831956010318 0.427284629692079 0.779739063699156 0.666666666666667 11.4 11 4 increased endoplasmic reticulum stress 0.1831956010318 0.427284629692079 0.779739063699156 0.666666666666667 11.4 11 4 respiratory distress 4.85906699085185e-08 1.30669504213448e-06 0.777485482590199 0.664739884393064 11.4 11 4 decreased lymphocyte cell number 2.76209170017157e-06 4.64236696228161e-05 0.776693207981581 0.6640625 11.4 11 4 increased sensitivity to xenobiotic induced morbidity/mortality 1.40630584257271e-05 0.000203382894383699 0.776194795227796 0.663636363636364 11.4 11 4 abnormal dendritic cell physiology 1.8462544802053e-05 0.000258735663071024 0.77609542321458 0.663551401869159 11.4 11 4 small seminiferous tubules 0.000378377737024958 0.00363007128017018 0.774470556511999 0.662162162162162 11.4 11 4 decreased circulating alanine transaminase level 0.000659959167789383 0.00582144833289394 0.77400568823078 0.661764705882353 11.4 11 4 cyanosis 1.56896014141937e-08 4.56583296470985e-07 0.773647352264006 0.661458333333333 11.4 11 4 abnormal pancreatic islet morphology 0.00269316373255823 0.0182540729829389 0.772383034796334 0.660377358490566 11.4 11 4 abnormal interventricular septum morphology 0.00358025789131603 0.0231021828914361 0.771941673062164 0.66 11.4 11 4 abnormal innervation 0.00476655924521977 0.0292399904376922 0.771443967276824 0.659574468085106 11.4 11 4 short femur 0.000138666898927756 0.00151953264794182 0.770878392520756 0.659090909090909 11.4 11 4 embryonic lethality, incomplete penetrance 0.0063564695091786 0.0364969768723731 0.770878392520756 0.659090909090909 11.4 11 4 no abnormal phenotype detected 4.30555830202407e-65 4.28403051051395e-62 0.770526008479656 0.658789625360231 11.4 11 4 abnormal compact bone morphology 0.0113712667461633 0.057143486931477 0.769479339176799 0.657894736842105 11.4 11 4 thick pulmonary interalveolar septum 0.0152635032973748 0.0736526953486318 0.768599934217739 0.657142857142857 11.4 11 4 ovary cysts 0.0152635032973748 0.0736526953486318 0.768599934217739 0.657142857142857 11.4 11 4 increased total body fat amount 3.73896186852599e-06 6.17491923310159e-05 0.768101167226034 0.656716417910448 11.4 11 4 internal hemorrhage 0.000962106711610228 0.0077326024075297 0.768101167226034 0.656716417910448 11.4 11 4 abnormal motor coordination/ balance 6.71731189495965e-05 0.000821096478560793 0.76792483546129 0.656565656565657 11.4 11 4 polydipsia 0.0205476630151752 0.0901101645011464 0.767555640828857 0.65625 11.4 11 4 abnormal heart atrium morphology 0.0205476630151752 0.0901101645011464 0.767555640828857 0.65625 11.4 11 4 thrombocytosis 0.00223160485958796 0.01568827556168 0.766295286738826 0.655172413793103 11.4 11 4 abnormal middle ear morphology 0.0277565209957923 0.114122885912452 0.766295286738826 0.655172413793103 11.4 11 4 focal hair loss 0.0277565209957923 0.114122885912452 0.766295286738826 0.655172413793103 11.4 11 4 enlarged epididymis 0.0277565209957923 0.114122885912452 0.766295286738826 0.655172413793103 11.4 11 4 polychromatophilia 0.0277565209957923 0.114122885912452 0.766295286738826 0.655172413793103 11.4 11 4 arrest of spermatogenesis 0.000264416595089547 0.00266830133989958 0.765815151847385 0.654761904761905 11.4 11 4 lung inflammation 4.10898733665928e-06 6.65870097715959e-05 0.765405625028216 0.654411764705882 11.4 11 4 abnormal xiphoid process morphology 0.0376498809095677 0.14486323087788 0.764744081704941 0.653846153846154 11.4 11 4 abnormal stomach morphology 0.0376498809095677 0.14486323087788 0.764744081704941 0.653846153846154 11.4 11 4 abnormal kidney cortex morphology 0.0376498809095677 0.14486323087788 0.764744081704941 0.653846153846154 11.4 11 4 increased susceptibility to otitis media 0.0376498809095677 0.14486323087788 0.764744081704941 0.653846153846154 11.4 11 4 increased leukemia incidence 0.0376498809095677 0.14486323087788 0.764744081704941 0.653846153846154 11.4 11 4 abnormal erythrocyte osmotic lysis 0.0376498809095677 0.14486323087788 0.764744081704941 0.653846153846154 11.4 11 4 abnormal limb morphology 0.000605157845586086 0.00546399325188889 0.764144282425173 0.653333333333333 11.4 11 4 decreased urine osmolality 0.00522764103684152 0.031486094622623 0.763826021582846 0.653061224489796 11.4 11 4 increased fluid intake 0.00522764103684152 0.031486094622623 0.763826021582846 0.653061224489796 11.4 11 4 abnormal neuromuscular synapse morphology 0.000798456055467865 0.00668848819358656 0.76349449987209 0.652777777777778 11.4 11 4 cochlear outer hair cell degeneration 0.000798456055467865 0.00668848819358656 0.76349449987209 0.652777777777778 11.4 11 4 abnormal epidermal layer morphology 0.00105421935089492 0.00840503408766384 0.762788214488305 0.652173913043478 11.4 11 4 abnormal inner ear morphology 0.00696228813269179 0.0392714098187547 0.762788214488304 0.652173913043478 11.4 11 4 abnormal forelimb morphology 0.00696228813269179 0.0392714098187547 0.762788214488304 0.652173913043478 11.4 11 4 abnormal blood vessel physiology 0.0513288552097505 0.174665564068747 0.762788214488304 0.652173913043478 11.4 11 4 abnormal nasal cavity morphology 0.0513288552097505 0.174665564068747 0.762788214488304 0.652173913043478 11.4 11 4 abnormal crista ampullaris morphology 0.0513288552097505 0.174665564068747 0.762788214488304 0.652173913043478 11.4 11 4 abnormal palatal shelf fusion at midline 0.0513288552097505 0.174665564068747 0.762788214488304 0.652173913043478 11.4 11 4 decreased effector memory CD8-positive, alpha-beta T cell number 0.0513288552097505 0.174665564068747 0.762788214488304 0.652173913043478 11.4 11 4 increased monocyte cell number 0.000105816499737786 0.001199173317074 0.760245587106677 0.65 11.4 11 4 decreased double-positive T cell number 0.000105816499737786 0.001199173317074 0.760245587106677 0.65 11.4 11 4 abnormal female reproductive system morphology 0.0124151909896596 0.062075954948298 0.760245587106677 0.65 11.4 11 4 waved hair 0.0704233167154404 0.224731238395969 0.760245587106677 0.65 11.4 11 4 small gonad 0.0704233167154404 0.224731238395969 0.760245587106677 0.65 11.4 11 4 abnormal fibula morphology 0.0704233167154404 0.224731238395969 0.760245587106677 0.65 11.4 11 4 decreased paired-pulse facilitation 0.0704233167154404 0.224731238395969 0.760245587106677 0.65 11.4 11 4 abnormal lens epithelium morphology 0.0704233167154404 0.224731238395969 0.760245587106677 0.65 11.4 11 4 absent placental labyrinth 0.0704233167154404 0.224731238395969 0.760245587106677 0.65 11.4 11 4 abnormal incus morphology 0.0704233167154404 0.224731238395969 0.760245587106677 0.65 11.4 11 4 increased urine calcium level 0.0704233167154404 0.224731238395969 0.760245587106677 0.65 11.4 11 4 decreased muscle cell glucose uptake 0.0704233167154404 0.224731238395969 0.760245587106677 0.65 11.4 11 4 increased insulin secretion 0.0166314080609754 0.0796354717067878 0.75866503495053 0.648648648648649 11.4 11 4 abnormal pancreatic beta cell physiology 0.0166314080609754 0.0796354717067878 0.75866503495053 0.648648648648649 11.4 11 4 abnormal humerus morphology 0.0166314080609754 0.0796354717067878 0.75866503495053 0.648648648648649 11.4 11 4 abnormal ovary morphology 0.00114863502833256 0.00909945742986382 0.757774583031574 0.647887323943662 11.4 11 4 teratozoospermia 0.000315209297266105 0.00309614320470652 0.757587385753157 0.647727272727273 11.4 11 4 abnormal oocyte morphology 0.022336239613144 0.0952209015213295 0.756805561825651 0.647058823529412 11.4 11 4 hydroureter 0.0974161834359081 0.26790677039786 0.756805561825651 0.647058823529412 11.4 11 4 abnormal cranial suture morphology 0.0974161834359081 0.26790677039786 0.756805561825651 0.647058823529412 11.4 11 4 decreased vasoconstriction 0.0974161834359081 0.26790677039786 0.756805561825651 0.647058823529412 11.4 11 4 abnormal ectoplacental cone morphology 0.0974161834359081 0.26790677039786 0.756805561825651 0.647058823529412 11.4 11 4 pancytopenia 0.0974161834359081 0.26790677039786 0.756805561825651 0.647058823529412 11.4 11 4 abnormal circulating chemokine level 0.0974161834359081 0.26790677039786 0.756805561825651 0.647058823529412 11.4 11 4 common atrium 0.0974161834359081 0.26790677039786 0.756805561825651 0.647058823529412 11.4 11 4 abnormal survival 0.0974161834359081 0.26790677039786 0.756805561825651 0.647058823529412 11.4 11 4 delayed heart development 0.0974161834359081 0.26790677039786 0.756805561825651 0.647058823529412 11.4 11 4 deafness 0.000151113033871287 0.0016343203119775 0.756110607223424 0.646464646464647 11.4 11 4 abnormal neuron morphology 0.000151113033871287 0.0016343203119775 0.756110607223424 0.646464646464647 11.4 11 4 abnormal hair shaft morphology 0.00756305594146992 0.0423241881988896 0.755372217958557 0.645833333333333 11.4 11 4 abnormal response to infection 0.000717671804176188 0.00615589176858024 0.755063776873233 0.645569620253165 11.4 11 4 decreased B cell proliferation 0.000717671804176188 0.00615589176858024 0.755063776873233 0.645569620253165 11.4 11 4 decreased food intake 0.000717671804176188 0.00615589176858024 0.755063776873233 0.645569620253165 11.4 11 4 absent mature ovarian follicles 0.0300872168946885 0.123095315831476 0.754586190676602 0.645161290322581 11.4 11 4 decreased double-negative T cell number 0.0300872168946885 0.123095315831476 0.754586190676602 0.645161290322581 11.4 11 4 abnormal cartilage development 0.0100707136963231 0.0529058084891312 0.753747761575851 0.644444444444444 11.4 11 4 abnormal colon morphology 0.00350167147272329 0.0226244358140239 0.753307231031388 0.644067796610169 11.4 11 4 increased body weight 2.95330319285897e-08 8.20820300808568e-07 0.751891239995615 0.642857142857143 11.4 11 4 dehydration 0.00164125581926005 0.012278567971156 0.751891239995615 0.642857142857143 11.4 11 4 abnormal stria vascularis morphology 0.0406706147481354 0.150659946665654 0.751891239995615 0.642857142857143 11.4 11 4 abnormal circulating cholesterol level 0.0406706147481354 0.150659946665654 0.751891239995615 0.642857142857143 11.4 11 4 abnormal retinal inner nuclear layer morphology 0.0406706147481354 0.150659946665654 0.751891239995615 0.642857142857143 11.4 11 4 abnormal hormone level 0.0406706147481354 0.150659946665654 0.751891239995615 0.642857142857143 11.4 11 4 abnormal renal tubule epithelium morphology 0.0406706147481354 0.150659946665654 0.751891239995615 0.642857142857143 11.4 11 4 abnormal interparietal bone morphology 0.136246283955218 0.352483235921585 0.751891239995615 0.642857142857143 11.4 11 4 extended life span 0.136246283955218 0.352483235921585 0.751891239995615 0.642857142857143 11.4 11 4 absent visceral yolk sac blood islands 0.136246283955218 0.352483235921585 0.751891239995615 0.642857142857143 11.4 11 4 abnormal adrenal gland secretion 0.136246283955218 0.352483235921585 0.751891239995615 0.642857142857143 11.4 11 4 decreased coping response 0.136246283955218 0.352483235921585 0.751891239995615 0.642857142857143 11.4 11 4 abnormal sagittal suture morphology 0.136246283955218 0.352483235921585 0.751891239995615 0.642857142857143 11.4 11 4 abnormal pancreas development 0.136246283955218 0.352483235921585 0.751891239995615 0.642857142857143 11.4 11 4 abnormal iris pigmentation 0.136246283955218 0.352483235921585 0.751891239995615 0.642857142857143 11.4 11 4 increased circulating growth hormone level 0.136246283955218 0.352483235921585 0.751891239995615 0.642857142857143 11.4 11 4 increased lung compliance 0.136246283955218 0.352483235921585 0.751891239995615 0.642857142857143 11.4 11 4 decreased compact bone area 0.136246283955218 0.352483235921585 0.751891239995615 0.642857142857143 11.4 11 4 increased inflammatory response 0.000281625627797868 0.00282477318204515 0.751011835036555 0.642105263157895 11.4 11 4 decreased B-1 B cell number 0.0179492264510987 0.0836117992455207 0.749749099710727 0.641025641025641 11.4 11 4 decreased litter size 9.00892119266579e-10 3.22441603838218e-08 0.749215470458264 0.640569395017794 11.4 11 4 abnormal nest building behavior 0.0552093378422907 0.186975123053367 0.74854950115119 0.64 11.4 11 4 diaphragmatic hernia 0.0552093378422907 0.186975123053367 0.74854950115119 0.64 11.4 11 4 abnormal uterus morphology 0.0240368962276988 0.101085003155369 0.747249936045024 0.638888888888889 11.4 11 4 abnormal epidermis stratum granulosum morphology 0.0240368962276988 0.101085003155369 0.747249936045024 0.638888888888889 11.4 11 4 abnormal trabecular bone morphology 6.99608421984683e-05 0.00085307644592495 0.746976918165578 0.638655462184874 11.4 11 4 abnormal lipid level 0.000835837837706238 0.00691683682306447 0.746858500772083 0.63855421686747 11.4 11 4 abnormal tibia morphology 0.0108371038164659 0.0549028426547026 0.74655867800983 0.638297872340426 11.4 11 4 abnormal spermiogenesis 0.00498896596737959 0.0304666513243214 0.74612962129833 0.637931034482759 11.4 11 4 small ovary 0.000521450634048011 0.00476003101722726 0.745464819140951 0.637362637362637 11.4 11 4 increased spleen weight 0.000119508316989742 0.0013183012794323 0.745237335216892 0.63716814159292 11.4 11 4 abnormal suckling behavior 0.000683707913858704 0.00592868388063927 0.744296378985558 0.636363636363636 11.4 11 4 increased liver weight 0.000683707913858704 0.00592868388063927 0.744296378985558 0.636363636363636 11.4 11 4 abnormal abdominal fat pad morphology 0.0753330388427207 0.236157638588696 0.744296378985558 0.636363636363636 11.4 11 4 testis hypoplasia 0.0753330388427207 0.236157638588696 0.744296378985558 0.636363636363636 11.4 11 4 abnormal limb posture 0.0753330388427207 0.236157638588696 0.744296378985558 0.636363636363636 11.4 11 4 cleft upper lip 0.0753330388427207 0.236157638588696 0.744296378985558 0.636363636363636 11.4 11 4 decreased circulating estradiol level 0.0753330388427207 0.236157638588696 0.744296378985558 0.636363636363636 11.4 11 4 abnormal temporal bone morphology 0.0753330388427207 0.236157638588696 0.744296378985558 0.636363636363636 11.4 11 4 increased circulating creatine kinase level 0.0753330388427207 0.236157638588696 0.744296378985558 0.636363636363636 11.4 11 4 increased bone volume 0.0753330388427207 0.236157638588696 0.744296378985558 0.636363636363636 11.4 11 4 increased mast cell number 0.193547007856912 0.435996205930821 0.744296378985558 0.636363636363636 11.4 11 4 abnormal enteric ganglia morphology 0.193547007856912 0.435996205930821 0.744296378985558 0.636363636363636 11.4 11 4 abnormal glossopharyngeal ganglion morphology 0.193547007856912 0.435996205930821 0.744296378985558 0.636363636363636 11.4 11 4 social withdrawal 0.193547007856912 0.435996205930821 0.744296378985558 0.636363636363636 11.4 11 4 vasculitis 0.193547007856912 0.435996205930821 0.744296378985558 0.636363636363636 11.4 11 4 secondary sex reversal 0.193547007856912 0.435996205930821 0.744296378985558 0.636363636363636 11.4 11 4 abnormal vestibular ganglion morphology 0.193547007856912 0.435996205930821 0.744296378985558 0.636363636363636 11.4 11 4 fatigue 0.193547007856912 0.435996205930821 0.744296378985558 0.636363636363636 11.4 11 4 retinal detachment 0.193547007856912 0.435996205930821 0.744296378985558 0.636363636363636 11.4 11 4 patent ductus arteriosus 0.193547007856912 0.435996205930821 0.744296378985558 0.636363636363636 11.4 11 4 abnormal frequency of paradoxical sleep 0.193547007856912 0.435996205930821 0.744296378985558 0.636363636363636 11.4 11 4 rectal hemorrhage 0.193547007856912 0.435996205930821 0.744296378985558 0.636363636363636 11.4 11 4 impaired luteinization 0.193547007856912 0.435996205930821 0.744296378985558 0.636363636363636 11.4 11 4 abnormal lymph circulation 0.193547007856912 0.435996205930821 0.744296378985558 0.636363636363636 11.4 11 4 abnormal ureter development 0.193547007856912 0.435996205930821 0.744296378985558 0.636363636363636 11.4 11 4 abnormal coronal suture morphology 0.193547007856912 0.435996205930821 0.744296378985558 0.636363636363636 11.4 11 4 abnormal spinal cord ventral horn morphology 0.193547007856912 0.435996205930821 0.744296378985558 0.636363636363636 11.4 11 4 abnormal Bruch membrane morphology 0.193547007856912 0.435996205930821 0.744296378985558 0.636363636363636 11.4 11 4 aberrant origin of the right subclavian artery 0.193547007856912 0.435996205930821 0.744296378985558 0.636363636363636 11.4 11 4 shortened PR interval 0.193547007856912 0.435996205930821 0.744296378985558 0.636363636363636 11.4 11 4 decreased core body temperature 0.193547007856912 0.435996205930821 0.744296378985558 0.636363636363636 11.4 11 4 increased pancreatic beta cell proliferation 0.193547007856912 0.435996205930821 0.744296378985558 0.636363636363636 11.4 11 4 decreased embryonic cilium length 0.193547007856912 0.435996205930821 0.744296378985558 0.636363636363636 11.4 11 4 abnormal contextual conditioning behavior 0.00660029255755724 0.0374845382121544 0.744296378985558 0.636363636363636 11.4 11 4 abnormal aorta morphology 0.0322687907843619 0.126806662047552 0.744296378985558 0.636363636363636 11.4 11 4 abnormal ovarian folliculogenesis 0.0322687907843619 0.126806662047552 0.744296378985558 0.636363636363636 11.4 11 4 dilated heart atrium 0.0322687907843619 0.126806662047552 0.744296378985558 0.636363636363636 11.4 11 4 abnormal middle ear ossicle morphology 0.0322687907843619 0.126806662047552 0.744296378985558 0.636363636363636 11.4 11 4 decreased B cell number 3.0309688824315e-07 6.44404708978491e-06 0.743780223382933 0.635922330097087 11.4 11 4 absent corpus luteum 0.00874006302212913 0.0477822126759257 0.742251608713619 0.634615384615385 11.4 11 4 decreased body temperature 0.00874006302212913 0.0477822126759257 0.742251608713619 0.634615384615385 11.4 11 4 increased metastatic potential 0.043444212048371 0.156759780375833 0.740752110514198 0.633333333333333 11.4 11 4 abnormal epidermis stratum corneum morphology 0.01158515938833 0.0581596043965103 0.739956458408383 0.63265306122449 11.4 11 4 abnormal spatial learning 8.00958444322828e-06 0.000124136082881809 0.739077824181102 0.631901840490798 11.4 11 4 increased macrophage cell number 0.00704869460152311 0.0395792953076495 0.738700165609727 0.631578947368421 11.4 11 4 increased bone marrow cell number 0.0256487931720819 0.106513143598587 0.738700165609727 0.631578947368421 11.4 11 4 abnormal retinal outer nuclear layer morphology 0.0256487931720819 0.106513143598587 0.738700165609727 0.631578947368421 11.4 11 4 shiny skin 0.103457066763203 0.278215625484831 0.738700165609727 0.631578947368421 11.4 11 4 short vibrissae 0.103457066763203 0.278215625484831 0.738700165609727 0.631578947368421 11.4 11 4 unresponsive to tactile stimuli 0.103457066763203 0.278215625484831 0.738700165609727 0.631578947368421 11.4 11 4 abnormal optic vesicle formation 0.103457066763203 0.278215625484831 0.738700165609727 0.631578947368421 11.4 11 4 abnormal sternebra morphology 0.103457066763203 0.278215625484831 0.738700165609727 0.631578947368421 11.4 11 4 abnormal cochlear inner hair cell morphology 0.103457066763203 0.278215625484831 0.738700165609727 0.631578947368421 11.4 11 4 abnormal sleep pattern 0.0153733220107529 0.0741107335305193 0.737361940672028 0.630434782608696 11.4 11 4 polyphagia 0.00931262543301833 0.050856543939919 0.73642022682698 0.62962962962963 11.4 11 4 abnormal palate morphology 0.0586872478619469 0.193741909829586 0.73642022682698 0.62962962962963 11.4 11 4 increased circulating HDL cholesterol level 0.000396738839227285 0.00375957280982047 0.73518254577349 0.628571428571429 11.4 11 4 abnormal intestinal goblet cell morphology 0.0343054856859844 0.134207865286089 0.73518254577349 0.628571428571429 11.4 11 4 decreased T cell number 1.53186260404928e-05 0.000220591248043943 0.733729615841131 0.627329192546584 11.4 11 4 syndactyly 0.00749032489021059 0.0420116869546761 0.733483356530562 0.627118644067797 11.4 11 4 abnormal locomotor activation 0.00108443772037073 0.00862130212522698 0.732611977431625 0.626373626373626 11.4 11 4 abnormal heart left ventricle morphology 0.00370334586792138 0.0235001858327919 0.731005372217959 0.625 11.4 11 4 abnormal seminal vesicle morphology 0.00987267672085581 0.0519752028426007 0.731005372217959 0.625 11.4 11 4 abnormal phalanx morphology 0.0162938502747925 0.078245082159356 0.731005372217959 0.625 11.4 11 4 curly vibrissae 0.0795969404003807 0.24368909445655 0.731005372217959 0.625 11.4 11 4 abnormal startle reflex 0.0795969404003807 0.24368909445655 0.731005372217959 0.625 11.4 11 4 blindness 0.0795969404003807 0.24368909445655 0.731005372217959 0.625 11.4 11 4 abnormal sensory capabilities/reflexes/nociception 0.0795969404003807 0.24368909445655 0.731005372217959 0.625 11.4 11 4 increased circulating total protein level 0.0795969404003807 0.24368909445655 0.731005372217959 0.625 11.4 11 4 abnormal mouth morphology 0.143263793329074 0.353891445785573 0.731005372217959 0.625 11.4 11 4 abnormal pituitary gland morphology 0.143263793329074 0.353891445785573 0.731005372217959 0.625 11.4 11 4 abnormal intestinal absorption 0.143263793329074 0.353891445785573 0.731005372217959 0.625 11.4 11 4 intraventricular hemorrhage 0.143263793329074 0.353891445785573 0.731005372217959 0.625 11.4 11 4 paternal imprinting 0.143263793329074 0.353891445785573 0.731005372217959 0.625 11.4 11 4 abnormal pulmonary elastic fiber morphology 0.143263793329074 0.353891445785573 0.731005372217959 0.625 11.4 11 4 bowed tibia 0.143263793329074 0.353891445785573 0.731005372217959 0.625 11.4 11 4 bowed radius 0.143263793329074 0.353891445785573 0.731005372217959 0.625 11.4 11 4 increased cochlear outer hair cell number 0.143263793329074 0.353891445785573 0.731005372217959 0.625 11.4 11 4 abnormal epididymis epithelium morphology 0.143263793329074 0.353891445785573 0.731005372217959 0.625 11.4 11 4 abnormal wound healing 0.143263793329074 0.353891445785573 0.731005372217959 0.625 11.4 11 4 decreased circulating growth hormone level 0.143263793329074 0.353891445785573 0.731005372217959 0.625 11.4 11 4 abnormal ear pigmentation 0.281587271356256 0.517562884080369 0.731005372217959 0.625 11.4 11 4 abnormal hypoglossal nerve morphology 0.281587271356256 0.517562884080369 0.731005372217959 0.625 11.4 11 4 dry eyes 0.281587271356256 0.517562884080369 0.731005372217959 0.625 11.4 11 4 unidirectional circling 0.281587271356256 0.517562884080369 0.731005372217959 0.625 11.4 11 4 poor grooming 0.281587271356256 0.517562884080369 0.731005372217959 0.625 11.4 11 4 abnormal erythrocyte cell number 0.281587271356256 0.517562884080369 0.731005372217959 0.625 11.4 11 4 preneoplasia 0.281587271356256 0.517562884080369 0.731005372217959 0.625 11.4 11 4 abnormal respiratory mucosa goblet cell morphology 0.281587271356256 0.517562884080369 0.731005372217959 0.625 11.4 11 4 head spot 0.281587271356256 0.517562884080369 0.731005372217959 0.625 11.4 11 4 vascular smooth muscle hypertrophy 0.281587271356256 0.517562884080369 0.731005372217959 0.625 11.4 11 4 hypospadia 0.281587271356256 0.517562884080369 0.731005372217959 0.625 11.4 11 4 absent tympanic ring 0.281587271356256 0.517562884080369 0.731005372217959 0.625 11.4 11 4 calcified muscle 0.281587271356256 0.517562884080369 0.731005372217959 0.625 11.4 11 4 liver failure 0.281587271356256 0.517562884080369 0.731005372217959 0.625 11.4 11 4 hair follicle degeneration 0.281587271356256 0.517562884080369 0.731005372217959 0.625 11.4 11 4 pulmonary interstitial fibrosis 0.281587271356256 0.517562884080369 0.731005372217959 0.625 11.4 11 4 abnormal forelimb zeugopod morphology 0.281587271356256 0.517562884080369 0.731005372217959 0.625 11.4 11 4 abnormal skin development 0.281587271356256 0.517562884080369 0.731005372217959 0.625 11.4 11 4 thin stria vascularis 0.281587271356256 0.517562884080369 0.731005372217959 0.625 11.4 11 4 bowed fibula 0.281587271356256 0.517562884080369 0.731005372217959 0.625 11.4 11 4 small frontal bone 0.281587271356256 0.517562884080369 0.731005372217959 0.625 11.4 11 4 abnormal hair follicle melanocyte morphology 0.281587271356256 0.517562884080369 0.731005372217959 0.625 11.4 11 4 absent cochlear microphonics 0.281587271356256 0.517562884080369 0.731005372217959 0.625 11.4 11 4 abnormal vestibular labyrinth morphology 0.281587271356256 0.517562884080369 0.731005372217959 0.625 11.4 11 4 enlarged inguinal lymph nodes 0.281587271356256 0.517562884080369 0.731005372217959 0.625 11.4 11 4 urinary bladder inflammation 0.281587271356256 0.517562884080369 0.731005372217959 0.625 11.4 11 4 abnormal base-excision repair 0.281587271356256 0.517562884080369 0.731005372217959 0.625 11.4 11 4 abnormal olfactory bulb glomerular layer morphology 0.281587271356256 0.517562884080369 0.731005372217959 0.625 11.4 11 4 decreased hippocampus pyramidal cell number 0.281587271356256 0.517562884080369 0.731005372217959 0.625 11.4 11 4 abnormal circulating serum amyloid protein level 0.281587271356256 0.517562884080369 0.731005372217959 0.625 11.4 11 4 decreased quadriceps weight 0.281587271356256 0.517562884080369 0.731005372217959 0.625 11.4 11 4 ostium secundum atrial septal defect 0.281587271356256 0.517562884080369 0.731005372217959 0.625 11.4 11 4 pulmonary artery hypoplasia 0.281587271356256 0.517562884080369 0.731005372217959 0.625 11.4 11 4 increased susceptibility to parasitic infection induced morbidity/mortality 0.281587271356256 0.517562884080369 0.731005372217959 0.625 11.4 11 4 abnormal bronchus epithelium morphology 0.281587271356256 0.517562884080369 0.731005372217959 0.625 11.4 11 4 absent ureteric bud 0.281587271356256 0.517562884080369 0.731005372217959 0.625 11.4 11 4 decreased surfactant secretion 0.281587271356256 0.517562884080369 0.731005372217959 0.625 11.4 11 4 absent Reichert's membrane 0.281587271356256 0.517562884080369 0.731005372217959 0.625 11.4 11 4 increased cardiac stroke volume 0.281587271356256 0.517562884080369 0.731005372217959 0.625 11.4 11 4 shortened PQ interval 0.281587271356256 0.517562884080369 0.731005372217959 0.625 11.4 11 4 increased cornea thickness 0.281587271356256 0.517562884080369 0.731005372217959 0.625 11.4 11 4 retropleural edema 0.281587271356256 0.517562884080369 0.731005372217959 0.625 11.4 11 4 embryo cyst 0.281587271356256 0.517562884080369 0.731005372217959 0.625 11.4 11 4 increased mammary gland apoptosis 0.281587271356256 0.517562884080369 0.731005372217959 0.625 11.4 11 4 decreased insulin secretion 0.00149760173566428 0.011254635400196 0.727756459452545 0.622222222222222 11.4 11 4 decreased osteoclast cell number 0.0215806487991274 0.0921577062452007 0.727756459452545 0.622222222222222 11.4 11 4 increased white adipose tissue amount 0.0362030553587442 0.140931299225159 0.727053991827591 0.621621621621622 11.4 11 4 impaired skeletal muscle contractility 0.0362030553587442 0.140931299225159 0.727053991827591 0.621621621621622 11.4 11 4 increased neutrophil cell number 7.69549530002697e-05 0.000924760606706139 0.725963955857835 0.620689655172414 11.4 11 4 cochlear ganglion degeneration 0.0104191596392125 0.0545634939000865 0.725963955857835 0.620689655172414 11.4 11 4 abnormal microglial cell morphology 0.0618027681610598 0.203486943481981 0.725963955857835 0.620689655172414 11.4 11 4 stomach inflammation 0.0618027681610598 0.203486943481981 0.725963955857835 0.620689655172414 11.4 11 4 short sternum 0.0618027681610598 0.203486943481981 0.725963955857835 0.620689655172414 11.4 11 4 testicular atrophy 0.0171795779841467 0.0815538172434444 0.725157329240215 0.62 11.4 11 4 abnormal axon extension 0.0171795779841467 0.0815538172434444 0.725157329240215 0.62 11.4 11 4 decreased exploration in new environment 0.00254627359576936 0.0173530289574693 0.724043416292073 0.619047619047619 11.4 11 4 increased food intake 0.00254627359576936 0.0173530289574693 0.724043416292073 0.619047619047619 11.4 11 4 abnormal cytotoxic T cell physiology 0.0286101217649553 0.117535388753635 0.724043416292073 0.619047619047619 11.4 11 4 increased incidence of induced tumors 0.108480722238848 0.290625521345326 0.724043416292073 0.619047619047619 11.4 11 4 decreased cochlear outer hair cell number 0.108480722238848 0.290625521345326 0.724043416292073 0.619047619047619 11.4 11 4 complete atrioventricular septal defect 0.108480722238848 0.290625521345326 0.724043416292073 0.619047619047619 11.4 11 4 abnormal retinal photoreceptor morphology 0.0483136811378676 0.166454683975686 0.722405309015394 0.617647058823529 11.4 11 4 lung hemorrhage 0.0483136811378676 0.166454683975686 0.722405309015394 0.617647058823529 11.4 11 4 impaired synaptic plasticity 0.0483136811378676 0.166454683975686 0.722405309015394 0.617647058823529 11.4 11 4 abnormal vision 0.0483136811378676 0.166454683975686 0.722405309015394 0.617647058823529 11.4 11 4 abnormal spleen red pulp morphology 0.0483136811378676 0.166454683975686 0.722405309015394 0.617647058823529 11.4 11 4 increased susceptibility to weight gain 0.0483136811378676 0.166454683975686 0.722405309015394 0.617647058823529 11.4 11 4 increased systemic arterial blood pressure 0.0226816735459932 0.0962809947878123 0.721673388742836 0.617021276595745 11.4 11 4 abnormal B cell differentiation 0.00215866416013396 0.0152547644839012 0.719759135722298 0.615384615384615 11.4 11 4 abnormal female meiosis 0.018030052424276 0.0839097388314061 0.719759135722298 0.615384615384615 11.4 11 4 abnormal lens fiber morphology 0.037968099925655 0.145862005505895 0.719759135722298 0.615384615384615 11.4 11 4 increased vascular permeability 0.037968099925655 0.145862005505895 0.719759135722298 0.615384615384615 11.4 11 4 abnormal Schwann cell morphology 0.0833044689346477 0.252707154237727 0.719759135722298 0.615384615384615 11.4 11 4 abnormal membranous labyrinth morphology 0.200591077219853 0.435996205930821 0.719759135722298 0.615384615384615 11.4 11 4 abnormal sympathetic ganglion morphology 0.200591077219853 0.435996205930821 0.719759135722298 0.615384615384615 11.4 11 4 abnormal digestion 0.200591077219853 0.435996205930821 0.719759135722298 0.615384615384615 11.4 11 4 lymphoid hypoplasia 0.200591077219853 0.435996205930821 0.719759135722298 0.615384615384615 11.4 11 4 abnormal otolith morphology 0.200591077219853 0.435996205930821 0.719759135722298 0.615384615384615 11.4 11 4 abnormal bile duct development 0.200591077219853 0.435996205930821 0.719759135722298 0.615384615384615 11.4 11 4 abnormal soleus morphology 0.200591077219853 0.435996205930821 0.719759135722298 0.615384615384615 11.4 11 4 absent lateral semicircular canal 0.200591077219853 0.435996205930821 0.719759135722298 0.615384615384615 11.4 11 4 abnormal GABAergic neuron morphology 0.200591077219853 0.435996205930821 0.719759135722298 0.615384615384615 11.4 11 4 vestibular hair cell degeneration 0.200591077219853 0.435996205930821 0.719759135722298 0.615384615384615 11.4 11 4 small interparietal bone 0.200591077219853 0.435996205930821 0.719759135722298 0.615384615384615 11.4 11 4 increased sensitivity to induced morbidity/mortality 2.01596838557567e-05 0.000278595631062194 0.71829223530982 0.614130434782609 11.4 11 4 abnormal photoreceptor outer segment morphology 0.0299637677680604 0.122792211405355 0.717714365450359 0.613636363636364 11.4 11 4 cochlear hair cell degeneration 0.0299637677680604 0.122792211405355 0.717714365450359 0.613636363636364 11.4 11 4 abnormal lung morphology 0.000575517863788325 0.00523437179588102 0.717490987185358 0.613445378151261 11.4 11 4 abnormal cranial ganglia morphology 0.0645927877083684 0.211274578543419 0.716856881142772 0.612903225806452 11.4 11 4 decreased susceptibility to bacterial infection induced morbidity/mortality 0.0645927877083684 0.211274578543419 0.716856881142772 0.612903225806452 11.4 11 4 increased anxiety-related response 0.000248259137104203 0.00251545663359147 0.715228277853542 0.611510791366906 11.4 11 4 reduced long term depression 0.0504418405490048 0.173081566843424 0.714760808390893 0.611111111111111 11.4 11 4 abnormal reflex 0.0504418405490048 0.173081566843424 0.714760808390893 0.611111111111111 11.4 11 4 lowered ear position 0.148729021439188 0.36539599094319 0.714760808390893 0.611111111111111 11.4 11 4 absent spleen 0.148729021439188 0.36539599094319 0.714760808390893 0.611111111111111 11.4 11 4 abnormal retinal rod cell morphology 0.148729021439188 0.36539599094319 0.714760808390893 0.611111111111111 11.4 11 4 blepharoptosis 0.148729021439188 0.36539599094319 0.714760808390893 0.611111111111111 11.4 11 4 eye inflammation 0.148729021439188 0.36539599094319 0.714760808390893 0.611111111111111 11.4 11 4 abnormal thymus medulla morphology 0.148729021439188 0.36539599094319 0.714760808390893 0.611111111111111 11.4 11 4 increased circulating glycerol level 0.148729021439188 0.36539599094319 0.714760808390893 0.611111111111111 11.4 11 4 decreased activity of thyroid 0.148729021439188 0.36539599094319 0.714760808390893 0.611111111111111 11.4 11 4 decreased heart rate variability 0.148729021439188 0.36539599094319 0.714760808390893 0.611111111111111 11.4 11 4 abnormal macrophage chemotaxis 0.148729021439188 0.36539599094319 0.714760808390893 0.611111111111111 11.4 11 4 decreased fluid intake 0.148729021439188 0.36539599094319 0.714760808390893 0.611111111111111 11.4 11 4 obese 0.00589155499787601 0.0344829248405096 0.713916934945331 0.61038961038961 11.4 11 4 increased B cell proliferation 0.015003422724607 0.072538414047541 0.713659482029736 0.610169491525424 11.4 11 4 scaly skin 0.0396076213937755 0.150659946665654 0.713175972895569 0.609756097560976 11.4 11 4 increased tumor growth/size 0.0396076213937755 0.150659946665654 0.713175972895569 0.609756097560976 11.4 11 4 delayed wound healing 0.031236490469932 0.126585796255688 0.711935666855751 0.608695652173913 11.4 11 4 blistering 0.112672880049563 0.301369665723967 0.711935666855751 0.608695652173913 11.4 11 4 pancreas inflammation 0.112672880049563 0.301369665723967 0.711935666855751 0.608695652173913 11.4 11 4 abnormal B cell morphology 0.112672880049563 0.301369665723967 0.711935666855751 0.608695652173913 11.4 11 4 decreased IgM level 0.002464601283424 0.0169550636889935 0.711411413787374 0.608247422680412 11.4 11 4 abnormal cued conditioning behavior 0.0247225632624559 0.10283842159759 0.710938558078642 0.607843137254902 11.4 11 4 reduced long term potentiation 0.00129339431572014 0.0101492692755642 0.710119504440303 0.607142857142857 11.4 11 4 reddish skin 0.0865311354014742 0.261697506761297 0.710119504440303 0.607142857142857 11.4 11 4 abnormal respiration 0.0865311354014742 0.261697506761297 0.710119504440303 0.607142857142857 11.4 11 4 increased bone resorption 0.0865311354014742 0.261697506761297 0.710119504440303 0.607142857142857 11.4 11 4 decreased neutrophil cell number 0.00104463465975192 0.00834198624761763 0.709762481059488 0.606837606837607 11.4 11 4 increased B cell number 0.00104463465975192 0.00834198624761763 0.709762481059488 0.606837606837607 11.4 11 4 increased double-negative T cell number 0.0156179970320074 0.075144618214929 0.709434721890216 0.60655737704918 11.4 11 4 abnormal male meiosis 0.0156179970320074 0.075144618214929 0.709434721890216 0.60655737704918 11.4 11 4 abnormal skeleton physiology 0.0670906004008236 0.218439618451634 0.70885369427196 0.606060606060606 11.4 11 4 decreased systemic arterial blood pressure 0.0670906004008236 0.218439618451634 0.70885369427196 0.606060606060606 11.4 11 4 abnormal T cell subpopulation ratio 0.0670906004008236 0.218439618451634 0.70885369427196 0.606060606060606 11.4 11 4 abnormal skeletal muscle fiber morphology 0.00995247693185282 0.0523399288963718 0.708354501529515 0.605633802816901 11.4 11 4 increased grooming behavior 0.0523862573782933 0.178020239383203 0.707920992042655 0.605263157894737 11.4 11 4 hyporesponsive to tactile stimuli 0.0523862573782933 0.178020239383203 0.707920992042655 0.605263157894737 11.4 11 4 abnormal intestinal epithelium morphology 0.032431509065194 0.127245076971089 0.70663852647736 0.604166666666667 11.4 11 4 abnormal cardiovascular system morphology 0.032431509065194 0.127245076971089 0.70663852647736 0.604166666666667 11.4 11 4 abnormal cytokine secretion 0.000246693887853845 0.00250469814708751 0.706322073935274 0.603896103896104 11.4 11 4 abnormal excitatory postsynaptic currents 0.00826403773894589 0.0456310629869654 0.704764153728083 0.602564102564103 11.4 11 4 impaired fertilization 0.0133796487092519 0.0662325893816203 0.70176515732924 0.6 11.4 11 4 altered response to myocardial infarction 0.0425384462214599 0.155039391906053 0.70176515732924 0.6 11.4 11 4 gastrointestinal hemorrhage 0.0893406023300935 0.26790677039786 0.70176515732924 0.6 11.4 11 4 abnormal spleen marginal zone morphology 0.0893406023300935 0.26790677039786 0.70176515732924 0.6 11.4 11 4 abnormal microglial cell physiology 0.0893406023300935 0.26790677039786 0.70176515732924 0.6 11.4 11 4 macrocytosis 0.205439865042194 0.435996205930821 0.70176515732924 0.6 11.4 11 4 decreased salivation 0.205439865042194 0.435996205930821 0.70176515732924 0.6 11.4 11 4 abnormal enteric neuron morphology 0.205439865042194 0.435996205930821 0.70176515732924 0.6 11.4 11 4 audiogenic seizures 0.205439865042194 0.435996205930821 0.70176515732924 0.6 11.4 11 4 abnormal bronchus morphology 0.205439865042194 0.435996205930821 0.70176515732924 0.6 11.4 11 4 abnormal lymph node B cell domain morphology 0.205439865042194 0.435996205930821 0.70176515732924 0.6 11.4 11 4 increased alcohol consumption 0.205439865042194 0.435996205930821 0.70176515732924 0.6 11.4 11 4 dilated ureter 0.205439865042194 0.435996205930821 0.70176515732924 0.6 11.4 11 4 greasy coat 0.205439865042194 0.435996205930821 0.70176515732924 0.6 11.4 11 4 abnormal rostral migratory stream morphology 0.205439865042194 0.435996205930821 0.70176515732924 0.6 11.4 11 4 abnormal olfactory nerve morphology 0.205439865042194 0.435996205930821 0.70176515732924 0.6 11.4 11 4 abnormal neurotransmitter secretion 0.205439865042194 0.435996205930821 0.70176515732924 0.6 11.4 11 4 abnormal energy homeostasis 0.205439865042194 0.435996205930821 0.70176515732924 0.6 11.4 11 4 abnormal dendritic cell morphology 0.205439865042194 0.435996205930821 0.70176515732924 0.6 11.4 11 4 abnormal secondary palate development 0.205439865042194 0.435996205930821 0.70176515732924 0.6 11.4 11 4 liver vascular congestion 0.205439865042194 0.435996205930821 0.70176515732924 0.6 11.4 11 4 abnormal branching involved in lung morphogenesis 0.205439865042194 0.435996205930821 0.70176515732924 0.6 11.4 11 4 increased body length 0.0335521964204815 0.131538358701257 0.70176515732924 0.6 11.4 11 4 impaired ovarian folliculogenesis 0.0541613214838919 0.183675919824378 0.70176515732924 0.6 11.4 11 4 perinatal lethality 0.0541613214838919 0.183675919824378 0.70176515732924 0.6 11.4 11 4 increased susceptibility to weight loss 0.0541613214838919 0.183675919824378 0.70176515732924 0.6 11.4 11 4 abnormal inner ear vestibule morphology 0.116178344237516 0.306299556217085 0.70176515732924 0.6 11.4 11 4 abnormal feces composition 0.116178344237516 0.306299556217085 0.70176515732924 0.6 11.4 11 4 decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 0.116178344237516 0.306299556217085 0.70176515732924 0.6 11.4 11 4 abnormal response to tactile stimuli 0.153007691834848 0.375351709506099 0.70176515732924 0.6 11.4 11 4 abnormal induced retinal neovascularization 0.153007691834848 0.375351709506099 0.70176515732924 0.6 11.4 11 4 enhanced behavioral response to xenobiotic 0.153007691834848 0.375351709506099 0.70176515732924 0.6 11.4 11 4 abnormal lateral semicircular canal morphology 0.285227458540087 0.517562884080369 0.70176515732924 0.6 11.4 11 4 kidney hemorrhage 0.285227458540087 0.517562884080369 0.70176515732924 0.6 11.4 11 4 small petrosal ganglion 0.285227458540087 0.517562884080369 0.70176515732924 0.6 11.4 11 4 abnormal prostate gland epithelium morphology 0.285227458540087 0.517562884080369 0.70176515732924 0.6 11.4 11 4 decreased circulating parathyroid hormone level 0.285227458540087 0.517562884080369 0.70176515732924 0.6 11.4 11 4 abnormal tibialis anterior morphology 0.285227458540087 0.517562884080369 0.70176515732924 0.6 11.4 11 4 peritoneal inflammation 0.285227458540087 0.517562884080369 0.70176515732924 0.6 11.4 11 4 cochlear ganglion hypoplasia 0.285227458540087 0.517562884080369 0.70176515732924 0.6 11.4 11 4 abnormal hindlimb zeugopod morphology 0.285227458540087 0.517562884080369 0.70176515732924 0.6 11.4 11 4 increased heart rate variability 0.285227458540087 0.517562884080369 0.70176515732924 0.6 11.4 11 4 abnormal cochlear inner hair cell physiology 0.285227458540087 0.517562884080369 0.70176515732924 0.6 11.4 11 4 abnormal corneal endothelium morphology 0.285227458540087 0.517562884080369 0.70176515732924 0.6 11.4 11 4 tachypnea 0.285227458540087 0.517562884080369 0.70176515732924 0.6 11.4 11 4 abnormal developmental vascular remodeling 0.285227458540087 0.517562884080369 0.70176515732924 0.6 11.4 11 4 abnormal sperm principal piece morphology 0.285227458540087 0.517562884080369 0.70176515732924 0.6 11.4 11 4 abnormal inflammatory response 0.0138175400653297 0.068332268215721 0.698516244563827 0.597222222222222 11.4 11 4 maternal effect 0.0173215688115582 0.0821494803026713 0.698273788387304 0.597014925373134 11.4 11 4 increased eosinophil cell number 0.0217594946334178 0.0928417545465296 0.697992226375857 0.596774193548387 11.4 11 4 abnormal spleen white pulp morphology 0.0557804149655694 0.188780656090958 0.696195592588532 0.595238095238095 11.4 11 4 abnormal eye electrophysiology 0.00204611866379304 0.0146466767660005 0.695965445285197 0.59504132231405 11.4 11 4 decreased IgG level 0.00314746269285594 0.0204955849436627 0.695442948704653 0.594594594594595 11.4 11 4 increased brown adipose tissue amount 0.0713253921613867 0.227463991027499 0.695442948704652 0.594594594594595 11.4 11 4 decreased eosinophil cell number 0.0224047664964862 0.0954312614041257 0.694455103607061 0.59375 11.4 11 4 neonatal lethality 0.0917866317551885 0.26790677039786 0.694455103607061 0.59375 11.4 11 4 abnormal auditory brainstem response waveform shape 0.0917866317551885 0.26790677039786 0.694455103607061 0.59375 11.4 11 4 increased thermal nociceptive threshold 0.00752478857884812 0.0421574585357763 0.694053452303644 0.593406593406593 11.4 11 4 abnormal cochlea morphology 0.0355842941705379 0.138739704936071 0.693101389954805 0.592592592592593 11.4 11 4 decreased tumor growth/size 0.0355842941705379 0.138739704936071 0.693101389954805 0.592592592592593 11.4 11 4 cryptorchism 0.119111335949485 0.313865940862653 0.693101389954805 0.592592592592593 11.4 11 4 abnormal basisphenoid bone morphology 0.156360709366588 0.381507861254918 0.691132351915161 0.590909090909091 11.4 11 4 intestinal ulcer 0.156360709366588 0.381507861254918 0.691132351915161 0.590909090909091 11.4 11 4 abnormal chorion morphology 0.156360709366588 0.381507861254918 0.691132351915161 0.590909090909091 11.4 11 4 increased coping response 0.156360709366588 0.381507861254918 0.691132351915161 0.590909090909091 11.4 11 4 decreased cardiac output 0.156360709366588 0.381507861254918 0.691132351915161 0.590909090909091 11.4 11 4 abnormal retinal layer morphology 0.156360709366588 0.381507861254918 0.691132351915161 0.590909090909091 11.4 11 4 abnormal retinal outer plexiform layer morphology 0.156360709366588 0.381507861254918 0.691132351915161 0.590909090909091 11.4 11 4 decreased susceptibility to viral infection induced morbidity/mortality 0.156360709366588 0.381507861254918 0.691132351915161 0.590909090909091 11.4 11 4 failure of palatal shelf elevation 0.156360709366588 0.381507861254918 0.691132351915161 0.590909090909091 11.4 11 4 abnormal cerebral cortex pyramidal cell morphology 0.156360709366588 0.381507861254918 0.691132351915161 0.590909090909091 11.4 11 4 pulmonary vascular congestion 0.156360709366588 0.381507861254918 0.691132351915161 0.590909090909091 11.4 11 4 impaired macrophage chemotaxis 0.0731123587164609 0.233013443058548 0.689769171733869 0.58974358974359 11.4 11 4 increased T cell proliferation 0.00526858051133241 0.0315417425317434 0.688648051584768 0.588785046728972 11.4 11 4 cochlear inner hair cell degeneration 0.0461659580748043 0.160276093106875 0.688005056205138 0.588235294117647 11.4 11 4 short maxilla 0.0939147707764747 0.26790677039786 0.688005056205138 0.588235294117647 11.4 11 4 enlarged sebaceous gland 0.20876037889074 0.435996205930821 0.688005056205138 0.588235294117647 11.4 11 4 increased regulatory T cell number 0.20876037889074 0.435996205930821 0.688005056205138 0.588235294117647 11.4 11 4 decreased growth hormone level 0.20876037889074 0.435996205930821 0.688005056205138 0.588235294117647 11.4 11 4 skin lesions 0.0296581313887809 0.121740267045532 0.686912984687352 0.587301587301587 11.4 11 4 abnormal CNS synaptic transmission 0.00833684211408935 0.0459820282900161 0.685225237796228 0.585858585858586 11.4 11 4 abnormal action potential 0.0241545121840329 0.101493832867875 0.685056463107115 0.585714285714286 11.4 11 4 abnormal response/metabolism to endogenous compounds 0.0157715834454124 0.0758102682521031 0.684648933979747 0.585365853658537 11.4 11 4 arrested B cell differentiation 0.0747077216111151 0.236157638588696 0.684648933979747 0.585365853658537 11.4 11 4 decreased anxiety-related response 0.00368026785938554 0.0233835665395186 0.684648933979746 0.585365853658537 11.4 11 4 abnormal eye physiology 0.038159543562015 0.14648435896684 0.682271680736761 0.583333333333333 11.4 11 4 abnormal cardiac muscle contractility 0.158979195558419 0.387706616619184 0.682271680736761 0.583333333333333 11.4 11 4 abnormal supraoccipital bone morphology 0.286506167388409 0.517562884080369 0.682271680736761 0.583333333333333 11.4 11 4 abnormal rectum morphology 0.286506167388409 0.517562884080369 0.682271680736761 0.583333333333333 11.4 11 4 increased litter size 0.286506167388409 0.517562884080369 0.682271680736761 0.583333333333333 11.4 11 4 increased papilloma incidence 0.286506167388409 0.517562884080369 0.682271680736761 0.583333333333333 11.4 11 4 abnormal corticospinal tract morphology 0.286506167388409 0.517562884080369 0.682271680736761 0.583333333333333 11.4 11 4 abnormal aorta elastic fiber morphology 0.286506167388409 0.517562884080369 0.682271680736761 0.583333333333333 11.4 11 4 abnormal alisphenoid bone morphology 0.286506167388409 0.517562884080369 0.682271680736761 0.583333333333333 11.4 11 4 stria vascularis degeneration 0.286506167388409 0.517562884080369 0.682271680736761 0.583333333333333 11.4 11 4 small parietal bone 0.286506167388409 0.517562884080369 0.682271680736761 0.583333333333333 11.4 11 4 abnormal cochlear outer hair cell physiology 0.286506167388409 0.517562884080369 0.682271680736761 0.583333333333333 11.4 11 4 abnormal anogenital distance 0.286506167388409 0.517562884080369 0.682271680736761 0.583333333333333 11.4 11 4 abnormal patella morphology 0.286506167388409 0.517562884080369 0.682271680736761 0.583333333333333 11.4 11 4 hydrometra 0.286506167388409 0.517562884080369 0.682271680736761 0.583333333333333 11.4 11 4 impaired behavioral response to cocaine 0.286506167388409 0.517562884080369 0.682271680736761 0.583333333333333 11.4 11 4 decreased prostaglandin level 0.286506167388409 0.517562884080369 0.682271680736761 0.583333333333333 11.4 11 4 abnormal aorta elastic tissue morphology 0.286506167388409 0.517562884080369 0.682271680736761 0.583333333333333 11.4 11 4 increased type II pneumocyte number 0.286506167388409 0.517562884080369 0.682271680736761 0.583333333333333 11.4 11 4 abnormal respiratory motile cilium morphology 0.286506167388409 0.517562884080369 0.682271680736761 0.583333333333333 11.4 11 4 increased circulating glucose level 0.00262212734275659 0.0177968397410833 0.680197906631178 0.581560283687943 11.4 11 4 abnormal digestive system physiology 0.0609295631327593 0.201010992430688 0.678372985418266 0.58 11.4 11 4 decreased threshold for auditory brainstem response 0.09736670248814 0.26790677039786 0.677141818475583 0.578947368421053 11.4 11 4 flaky skin 0.210977959118667 0.435996205930821 0.677141818475583 0.578947368421053 11.4 11 4 decreased grooming behavior 0.210977959118667 0.435996205930821 0.677141818475583 0.578947368421053 11.4 11 4 decreased tumor incidence 0.210977959118667 0.435996205930821 0.677141818475583 0.578947368421053 11.4 11 4 abnormal CD4-positive, alpha-beta T cell physiology 0.0320967223803929 0.126585796255688 0.675407780528142 0.577464788732394 11.4 11 4 no spontaneous movement 0.161006356014154 0.391881908596094 0.674774189739654 0.576923076923077 11.4 11 4 abnormal ocular fundus morphology 0.161006356014154 0.391881908596094 0.674774189739654 0.576923076923077 11.4 11 4 pulmonary edema 0.161006356014154 0.391881908596094 0.674774189739654 0.576923076923077 11.4 11 4 decreased Peyer's patch number 0.161006356014154 0.391881908596094 0.674774189739654 0.576923076923077 11.4 11 4 head bobbing 0.098751997325231 0.26790677039786 0.672524942440522 0.575 11.4 11 4 abnormal T-helper 1 physiology 0.0785190871549473 0.241131147281397 0.671902810208847 0.574468085106383 11.4 11 4 abnormal nervous system electrophysiology 0.0272776602860781 0.1125260032531 0.668347768884991 0.571428571428571 11.4 11 4 dry skin 0.212376984629515 0.435996205930821 0.668347768884991 0.571428571428571 11.4 11 4 abnormal stapes morphology 0.212376984629515 0.435996205930821 0.668347768884991 0.571428571428571 11.4 11 4 increased bone ossification 0.212376984629515 0.435996205930821 0.668347768884991 0.571428571428571 11.4 11 4 abnormal vasoconstriction 0.286384134906034 0.517562884080369 0.668347768884991 0.571428571428571 11.4 11 4 abnormal zigzag hair morphology 0.286384134906034 0.517562884080369 0.668347768884991 0.571428571428571 11.4 11 4 increased aggression towards males 0.286384134906034 0.517562884080369 0.668347768884991 0.571428571428571 11.4 11 4 abnormal spleen periarteriolar lymphoid sheath morphology 0.286384134906034 0.517562884080369 0.668347768884991 0.571428571428571 11.4 11 4 abnormal endplate potential 0.286384134906034 0.517562884080369 0.668347768884991 0.571428571428571 11.4 11 4 absent otoliths 0.286384134906034 0.517562884080369 0.668347768884991 0.571428571428571 11.4 11 4 abnormal kidney medulla morphology 0.286384134906034 0.517562884080369 0.668347768884991 0.571428571428571 11.4 11 4 abnormal prepulse inhibition 0.286384134906034 0.517562884080369 0.668347768884991 0.571428571428571 11.4 11 4 abnormal decidualization 0.286384134906034 0.517562884080369 0.668347768884991 0.571428571428571 11.4 11 4 enlarged stomach 0.286384134906034 0.517562884080369 0.668347768884991 0.571428571428571 11.4 11 4 decreased cornea thickness 0.286384134906034 0.517562884080369 0.668347768884991 0.571428571428571 11.4 11 4 abnormal respiratory motile cilium physiology 0.286384134906034 0.517562884080369 0.668347768884991 0.571428571428571 11.4 11 4 decreased response to antigen 0.286384134906034 0.517562884080369 0.668347768884991 0.571428571428571 11.4 11 4 abnormal circadian rhythm 0.10096429991454 0.272691309486882 0.664550338379962 0.568181818181818 11.4 11 4 abnormal gametogenesis 0.10096429991454 0.272691309486882 0.664550338379962 0.568181818181818 11.4 11 4 salivary gland inflammation 0.163699956165402 0.397438740620674 0.662778204144282 0.566666666666667 11.4 11 4 abnormal carpal bone morphology 0.21315488747872 0.436577013259214 0.661083119223197 0.565217391304348 11.4 11 4 abnormal circulating insulin level 0.21315488747872 0.436577013259214 0.661083119223197 0.565217391304348 11.4 11 4 abnormal lens development 0.21315488747872 0.436577013259214 0.661083119223197 0.565217391304348 11.4 11 4 abnormal T cell differentiation 0.023522074291824 0.0990874848448978 0.660076138081959 0.564356435643564 11.4 11 4 increased autoantibody level 0.128754676780901 0.335720396742653 0.65977920774544 0.564102564102564 11.4 11 4 abnormal circulating hormone level 0.128754676780901 0.335720396742653 0.65977920774544 0.564102564102564 11.4 11 4 abnormal serotonin level 0.164518461322631 0.397438740620674 0.657904834996163 0.5625 11.4 11 4 reduced male mating frequency 0.285380528673348 0.517562884080369 0.657904834996163 0.5625 11.4 11 4 abnormal extraembryonic endoderm formation 0.285380528673348 0.517562884080369 0.657904834996163 0.5625 11.4 11 4 impaired muscle relaxation 0.285380528673348 0.517562884080369 0.657904834996163 0.5625 11.4 11 4 abnormal level of surface class II molecules 0.285380528673348 0.517562884080369 0.657904834996163 0.5625 11.4 11 4 sepsis 0.285380528673348 0.517562884080369 0.657904834996163 0.5625 11.4 11 4 impaired behavioral response to addictive substance 0.285380528673348 0.517562884080369 0.657904834996163 0.5625 11.4 11 4 decreased skeletal muscle weight 0.285380528673348 0.517562884080369 0.657904834996163 0.5625 11.4 11 4 dilated respiratory conducting tubes 0.285380528673348 0.517562884080369 0.657904834996163 0.5625 11.4 11 4 abnormal social investigation 0.0435864917897356 0.156759780375833 0.657904834996163 0.5625 11.4 11 4 mandible hypoplasia 0.213453006330478 0.43664831681502 0.654980813507291 0.56 11.4 11 4 increased pre-B cell number 0.213453006330478 0.43664831681502 0.654980813507291 0.56 11.4 11 4 thin skin 0.16506068544689 0.397438740620674 0.653604803394881 0.558823529411765 11.4 11 4 abnormal skin physiology 0.16506068544689 0.397438740620674 0.653604803394881 0.558823529411765 11.4 11 4 increased susceptibility to viral infection induced morbidity/mortality 0.16506068544689 0.397438740620674 0.653604803394881 0.558823529411765 11.4 11 4 abnormal intestinal mucosa morphology 0.130025163989391 0.338678110391214 0.652804797515572 0.558139534883721 11.4 11 4 abnormal male reproductive system morphology 0.130025163989391 0.338678110391214 0.652804797515572 0.558139534883721 11.4 11 4 decreased IgA level 0.103660865563206 0.278613077351134 0.652281716748332 0.557692307692308 11.4 11 4 increased circulating corticosterone level 0.130425222637694 0.339542377091851 0.64978255308263 0.555555555555556 11.4 11 4 decreased susceptibility to pharmacologically induced seizures 0.21337513109499 0.43664831681502 0.64978255308263 0.555555555555556 11.4 11 4 abnormal stomach glandular epithelium morphology 0.283799575705181 0.517562884080369 0.64978255308263 0.555555555555556 11.4 11 4 abnormal phrenic nerve morphology 0.283799575705181 0.517562884080369 0.64978255308263 0.555555555555556 11.4 11 4 abnormal iron level 0.283799575705181 0.517562884080369 0.64978255308263 0.555555555555556 11.4 11 4 increased susceptibility to autoimmune disorder 0.283799575705181 0.517562884080369 0.64978255308263 0.555555555555556 11.4 11 4 impaired leukocyte tethering or rolling 0.283799575705181 0.517562884080369 0.64978255308263 0.555555555555556 11.4 11 4 abnormal sympathetic neuron morphology 0.404576859261828 0.61807016858041 0.64978255308263 0.555555555555556 11.4 11 4 small geniculate ganglion 0.404576859261828 0.61807016858041 0.64978255308263 0.555555555555556 11.4 11 4 small nodose ganglion 0.404576859261828 0.61807016858041 0.64978255308263 0.555555555555556 11.4 11 4 multifocal hepatic necrosis 0.404576859261828 0.61807016858041 0.64978255308263 0.555555555555556 11.4 11 4 abnormal thymus lobule morphology 0.404576859261828 0.61807016858041 0.64978255308263 0.555555555555556 11.4 11 4 abnormal posterior semicircular canal morphology 0.404576859261828 0.61807016858041 0.64978255308263 0.555555555555556 11.4 11 4 polycythemia 0.404576859261828 0.61807016858041 0.64978255308263 0.555555555555556 11.4 11 4 abnormal postural reflex 0.404576859261828 0.61807016858041 0.64978255308263 0.555555555555556 11.4 11 4 genetic imprinting 0.404576859261828 0.61807016858041 0.64978255308263 0.555555555555556 11.4 11 4 abnormal lens capsule morphology 0.404576859261828 0.61807016858041 0.64978255308263 0.555555555555556 11.4 11 4 priapism 0.404576859261828 0.61807016858041 0.64978255308263 0.555555555555556 11.4 11 4 decreased muscle weight 0.404576859261828 0.61807016858041 0.64978255308263 0.555555555555556 11.4 11 4 abnormal bony labyrinth 0.404576859261828 0.61807016858041 0.64978255308263 0.555555555555556 11.4 11 4 abnormal proprioceptive neuron morphology 0.404576859261828 0.61807016858041 0.64978255308263 0.555555555555556 11.4 11 4 absent cochlear outer hair cells 0.404576859261828 0.61807016858041 0.64978255308263 0.555555555555556 11.4 11 4 increased circulating progesterone level 0.404576859261828 0.61807016858041 0.64978255308263 0.555555555555556 11.4 11 4 increased stomach mucosa thickness 0.404576859261828 0.61807016858041 0.64978255308263 0.555555555555556 11.4 11 4 absent adrenal gland 0.404576859261828 0.61807016858041 0.64978255308263 0.555555555555556 11.4 11 4 multiflagellated sperm 0.404576859261828 0.61807016858041 0.64978255308263 0.555555555555556 11.4 11 4 abnormal hyoid bone lesser horn morphology 0.404576859261828 0.61807016858041 0.64978255308263 0.555555555555556 11.4 11 4 abnormal incisor color 0.404576859261828 0.61807016858041 0.64978255308263 0.555555555555556 11.4 11 4 shortened ST segment 0.404576859261828 0.61807016858041 0.64978255308263 0.555555555555556 11.4 11 4 decreased susceptibility to parasitic infection induced morbidity/mortality 0.404576859261828 0.61807016858041 0.64978255308263 0.555555555555556 11.4 11 4 abnormal heart left ventricle pressure 0.404576859261828 0.61807016858041 0.64978255308263 0.555555555555556 11.4 11 4 abnormal pulmonary alveolar system morphology 0.404576859261828 0.61807016858041 0.64978255308263 0.555555555555556 11.4 11 4 abnormal ureteric bud invasion 0.404576859261828 0.61807016858041 0.64978255308263 0.555555555555556 11.4 11 4 increased bone mineralization 0.404576859261828 0.61807016858041 0.64978255308263 0.555555555555556 11.4 11 4 decreased monocyte cell number 0.0839968955377364 0.254652379829518 0.647783222150068 0.553846153846154 11.4 11 4 enhanced long term potentiation 0.104360333022893 0.280341607337415 0.647461901107335 0.553571428571429 11.4 11 4 decreased bone strength 0.212999128706555 0.436577013259214 0.645301294095853 0.551724137931034 11.4 11 4 increased double-positive T cell number 0.212999128706555 0.436577013259214 0.645301294095853 0.551724137931034 11.4 11 4 abnormal dopamine level 0.281830508021111 0.517562884080369 0.643284727551803 0.55 11.4 11 4 abnormal Peyer's patch T cell area morphology 0.281830508021111 0.517562884080369 0.643284727551803 0.55 11.4 11 4 decreased skin tensile strength 0.281830508021111 0.517562884080369 0.643284727551803 0.55 11.4 11 4 abnormal heart right ventricle morphology 0.281830508021111 0.517562884080369 0.643284727551803 0.55 11.4 11 4 increased body size 0.279596514945025 0.517562884080369 0.637968324844764 0.545454545454545 11.4 11 4 abnormal primary sex determination 0.395243999359897 0.61807016858041 0.637968324844764 0.545454545454545 11.4 11 4 abnormal larynx morphology 0.395243999359897 0.61807016858041 0.637968324844764 0.545454545454545 11.4 11 4 allodynia 0.395243999359897 0.61807016858041 0.637968324844764 0.545454545454545 11.4 11 4 abnormal nerve fiber response 0.395243999359897 0.61807016858041 0.637968324844764 0.545454545454545 11.4 11 4 pulmonary hypertension 0.395243999359897 0.61807016858041 0.637968324844764 0.545454545454545 11.4 11 4 abnormal pituitary gland development 0.395243999359897 0.61807016858041 0.637968324844764 0.545454545454545 11.4 11 4 enlarged placenta 0.395243999359897 0.61807016858041 0.637968324844764 0.545454545454545 11.4 11 4 cyclopia 0.395243999359897 0.61807016858041 0.637968324844764 0.545454545454545 11.4 11 4 increased motor neuron number 0.395243999359897 0.61807016858041 0.637968324844764 0.545454545454545 11.4 11 4 abnormal platelet aggregation 0.395243999359897 0.61807016858041 0.637968324844764 0.545454545454545 11.4 11 4 abnormal superovulation 0.395243999359897 0.61807016858041 0.637968324844764 0.545454545454545 11.4 11 4 enhanced behavioral response to addictive substance 0.395243999359897 0.61807016858041 0.637968324844764 0.545454545454545 11.4 11 4 decreased palatine bone horizontal plate size 0.395243999359897 0.61807016858041 0.637968324844764 0.545454545454545 11.4 11 4 increased number of Howell-Jolly bodies 0.395243999359897 0.61807016858041 0.637968324844764 0.545454545454545 11.4 11 4 abnormal extraembryonic ectoderm morphology 0.395243999359897 0.61807016858041 0.637968324844764 0.545454545454545 11.4 11 4 abnormal phrenic nerve innervation pattern to diaphragm 0.395243999359897 0.61807016858041 0.637968324844764 0.545454545454545 11.4 11 4 abnormal T-helper 2 physiology 0.130722780107884 0.340139032968997 0.637968324844764 0.545454545454545 11.4 11 4 absent vibrissae 0.21157740574074 0.435996205930821 0.637968324844764 0.545454545454545 11.4 11 4 abnormal inhibitory postsynaptic currents 0.104713689101139 0.280987380408935 0.636404676989752 0.544117647058823 11.4 11 4 decreased susceptibility to injury 0.104713689101139 0.280987380408935 0.636404676989752 0.544117647058823 11.4 11 4 abnormal lymphocyte physiology 0.164466040357051 0.397438740620674 0.63565684540692 0.543478260869565 11.4 11 4 abnormal lymph node morphology 0.163941431425217 0.397438740620674 0.633537989255564 0.541666666666667 11.4 11 4 decreased metastatic potential 0.277180705202712 0.517562884080369 0.633537989255564 0.541666666666667 11.4 11 4 apnea 0.277180705202712 0.517562884080369 0.633537989255564 0.541666666666667 11.4 11 4 abnormal retinal ganglion layer morphology 0.277180705202712 0.517562884080369 0.633537989255564 0.541666666666667 11.4 11 4 abnormal response to injury 0.20832950673009 0.435996205930821 0.62978924375701 0.538461538461538 11.4 11 4 abnormal tectorial membrane morphology 0.274640765032856 0.51696473932594 0.62978924375701 0.538461538461538 11.4 11 4 small trigeminal ganglion 0.386740439251724 0.61807016858041 0.62978924375701 0.538461538461538 11.4 11 4 dystrophic cardiac calcinosis 0.386740439251724 0.61807016858041 0.62978924375701 0.538461538461538 11.4 11 4 abnormal dopaminergic neuron morphology 0.386740439251724 0.61807016858041 0.62978924375701 0.538461538461538 11.4 11 4 abnormal afterhyperpolarization 0.386740439251724 0.61807016858041 0.62978924375701 0.538461538461538 11.4 11 4 abnormal insulin secretion 0.386740439251724 0.61807016858041 0.62978924375701 0.538461538461538 11.4 11 4 muscle fatigue 0.386740439251724 0.61807016858041 0.62978924375701 0.538461538461538 11.4 11 4 increased cochlear inner hair cell number 0.386740439251724 0.61807016858041 0.62978924375701 0.538461538461538 11.4 11 4 increased circulating thyroid-stimulating hormone level 0.386740439251724 0.61807016858041 0.62978924375701 0.538461538461538 11.4 11 4 decreased luteinizing hormone level 0.386740439251724 0.61807016858041 0.62978924375701 0.538461538461538 11.4 11 4 increased renin activity 0.386740439251724 0.61807016858041 0.62978924375701 0.538461538461538 11.4 11 4 abnormal hair follicle inner root sheath morphology 0.386740439251724 0.61807016858041 0.62978924375701 0.538461538461538 11.4 11 4 abnormal excitatory postsynaptic potential 0.103025215017035 0.27795577261917 0.627594856148101 0.536585365853659 11.4 11 4 decreased inflammatory response 0.10266519742859 0.277134757030512 0.626576033329679 0.535714285714286 11.4 11 4 increased circulating luteinizing hormone level 0.272017663112092 0.515179736411686 0.626576033329679 0.535714285714286 11.4 11 4 abnormal spleen germinal center morphology 0.272017663112092 0.515179736411686 0.626576033329679 0.535714285714286 11.4 11 4 enhanced coordination 0.272017663112092 0.515179736411686 0.626576033329679 0.535714285714286 11.4 11 4 impaired macrophage phagocytosis 0.205701418576211 0.435996205930821 0.62560459761909 0.534883720930233 11.4 11 4 abnormal axon guidance 0.205701418576211 0.435996205930821 0.62560459761909 0.534883720930233 11.4 11 4 interdigital webbing 0.378891871893282 0.61807016858041 0.623791250959325 0.533333333333333 11.4 11 4 abnormal prostate gland morphology 0.378891871893282 0.61807016858041 0.623791250959325 0.533333333333333 11.4 11 4 abnormal apical ectodermal ridge morphology 0.378891871893282 0.61807016858041 0.623791250959325 0.533333333333333 11.4 11 4 increased airway responsiveness 0.378891871893282 0.61807016858041 0.623791250959325 0.533333333333333 11.4 11 4 abnormal respiratory system morphology 0.378891871893282 0.61807016858041 0.623791250959325 0.533333333333333 11.4 11 4 arthritis 0.378891871893282 0.61807016858041 0.623791250959325 0.533333333333333 11.4 11 4 decreased aggression towards males 0.378891871893282 0.61807016858041 0.623791250959325 0.533333333333333 11.4 11 4 abnormal cerebral aqueduct morphology 0.378891871893282 0.61807016858041 0.623791250959325 0.533333333333333 11.4 11 4 abnormal microglial cell activation 0.378891871893282 0.61807016858041 0.623791250959325 0.533333333333333 11.4 11 4 decreased trabecular bone mass 0.378891871893282 0.61807016858041 0.623791250959325 0.533333333333333 11.4 11 4 abnormal crypts of Lieberkuhn morphology 0.266632664806755 0.515179736411686 0.621354566385265 0.53125 11.4 11 4 abnormal urinary bladder morphology 0.371578197178782 0.61807016858041 0.619204550584624 0.529411764705882 11.4 11 4 distended urinary bladder 0.371578197178782 0.61807016858041 0.619204550584624 0.529411764705882 11.4 11 4 abnormal tendon morphology 0.371578197178782 0.61807016858041 0.619204550584624 0.529411764705882 11.4 11 4 abnormal systemic arterial blood pressure 0.261181330515583 0.505201057276449 0.617293425428498 0.527777777777778 11.4 11 4 abnormal long term depression 0.364712483023529 0.61807016858041 0.615583471341439 0.526315789473684 11.4 11 4 increased susceptibility to ischemic brain injury 0.364712483023529 0.61807016858041 0.615583471341439 0.526315789473684 11.4 11 4 decreased fertilization frequency 0.364712483023529 0.61807016858041 0.615583471341439 0.526315789473684 11.4 11 4 abnormal NK cell physiology 0.191984916391123 0.435996205930821 0.613565164878024 0.524590163934426 11.4 11 4 abnormal humoral immune response 0.115801640658376 0.30579254897846 0.612652121477908 0.523809523809524 11.4 11 4 increased acute inflammation 0.358229383751868 0.61807016858041 0.612652121477908 0.523809523809524 11.4 11 4 abnormal bile salt homeostasis 0.358229383751868 0.61807016858041 0.612652121477908 0.523809523809524 11.4 11 4 abnormal immune system morphology 0.247746635688313 0.495875736843294 0.610230571590644 0.521739130434783 11.4 11 4 hypotension 0.352078290362813 0.61807016858041 0.610230571590644 0.521739130434783 11.4 11 4 increased susceptibility to age related obesity 0.352078290362813 0.61807016858041 0.610230571590644 0.521739130434783 11.4 11 4 decreased epididymis weight 0.352078290362813 0.61807016858041 0.610230571590644 0.521739130434783 11.4 11 4 abnormal corneal stroma morphology 0.352078290362813 0.61807016858041 0.610230571590644 0.521739130434783 11.4 11 4 increased susceptibility to pharmacologically induced seizures 0.140810808569281 0.353891445785573 0.609171143514965 0.520833333333333 11.4 11 4 decreased T cell proliferation 0.0856538118669 0.259517487233756 0.608512580116571 0.52027027027027 11.4 11 4 decreased granulocyte number 0.335251807118025 0.60364739066673 0.604969963214862 0.517241379310345 11.4 11 4 absent long term depression 0.335251807118025 0.60364739066673 0.604969963214862 0.517241379310345 11.4 11 4 abnormal CD8-positive, alpha-beta T cell physiology 0.335251807118025 0.60364739066673 0.604969963214862 0.517241379310345 11.4 11 4 autoimmune response 0.330094689223592 0.595439114897523 0.603668952541282 0.516129032258065 11.4 11 4 abnormal CD8-positive, alpha beta T cell morphology 0.330094689223592 0.595439114897523 0.603668952541282 0.516129032258065 11.4 11 4 impaired behavioral response to xenobiotic 0.320338205735549 0.578259279221465 0.601512991996492 0.514285714285714 11.4 11 4 abnormal T cell activation 0.213941552077179 0.437467826380586 0.600609819335836 0.513513513513513 11.4 11 4 abnormal thrombosis 0.28695590495178 0.518187160484612 0.596271048711119 0.509803921568627 11.4 11 4 abnormal immune system physiology 0.167233865364672 0.397438740620674 0.594236625157824 0.508064516129032 11.4 11 4 increased activated T cell number 0.436862252558711 0.61807016858041 0.584804297774367 0.5 11.4 11 4 abnormal estrous cycle 0.401162574053892 0.61807016858041 0.584804297774367 0.5 11.4 11 4 abnormal tracheal cartilage morphology 0.436862252558711 0.61807016858041 0.584804297774367 0.5 11.4 11 4 abnormal female reproductive system physiology 0.436862252558711 0.61807016858041 0.584804297774367 0.5 11.4 11 4 decreased macrophage cell number 0.354955575464264 0.61807016858041 0.584804297774367 0.5 11.4 11 4 decreased regulatory T cell number 0.386349039057473 0.61807016858041 0.584804297774367 0.5 11.4 11 4 impaired humoral immune response 0.436862252558711 0.61807016858041 0.584804297774367 0.5 11.4 11 4 abnormal leukocyte migration 0.333927235916282 0.601915941551993 0.584804297774367 0.5 11.4 11 4 increased percent body fat/body weight 0.333927235916282 0.601915941551993 0.584804297774367 0.5 11.4 11 4 small seminal vesicle 0.41779732626241 0.61807016858041 0.584804297774367 0.5 11.4 11 4 increased stereotypic behavior 0.426975875522913 0.61807016858041 0.584804297774367 0.5 11.4 11 4 abnormal hearing physiology 0.447594458025948 0.61807016858041 0.584804297774367 0.5 11.4 11 4 abnormal muscle morphology 0.360712723388539 0.61807016858041 0.584804297774367 0.5 11.4 11 4 abnormal long term potentiation 0.393556713640429 0.61807016858041 0.584804297774367 0.5 11.4 11 4 abnormal diaphragm morphology 0.393556713640429 0.61807016858041 0.584804297774367 0.5 11.4 11 4 abnormal male reproductive system physiology 0.447594458025948 0.61807016858041 0.584804297774367 0.5 11.4 11 4 abnormal meiosis 0.472403215113216 0.631775805158131 0.584804297774367 0.5 11.4 11 4 decreased cochlear coiling 0.472403215113216 0.631775805158131 0.584804297774367 0.5 11.4 11 4 small epididymis 0.472403215113216 0.631775805158131 0.584804297774367 0.5 11.4 11 4 decreased circulating prolactin level 0.472403215113216 0.631775805158131 0.584804297774367 0.5 11.4 11 4 abnormal intestinal lipid absorption 0.472403215113216 0.631775805158131 0.584804297774367 0.5 11.4 11 4 abnormal Langerhans cell physiology 0.472403215113216 0.631775805158131 0.584804297774367 0.5 11.4 11 4 abnormal fertilization 0.472403215113216 0.631775805158131 0.584804297774367 0.5 11.4 11 4 loose skin 0.472403215113216 0.631775805158131 0.584804297774367 0.5 11.4 11 4 abnormal urinary bladder physiology 0.472403215113216 0.631775805158131 0.584804297774367 0.5 11.4 11 4 absent atrioventricular cushions 0.487096743597413 0.649854196673942 0.584804297774367 0.5 11.4 11 4 abnormal olfactory system physiology 0.487096743597413 0.649854196673942 0.584804297774367 0.5 11.4 11 4 abnormal voluntary movement 0.487096743597413 0.649854196673942 0.584804297774367 0.5 11.4 11 4 abnormal vascular endothelial cell migration 0.487096743597413 0.649854196673942 0.584804297774367 0.5 11.4 11 4 abnormal squamosal bone morphology 0.487096743597413 0.649854196673942 0.584804297774367 0.5 11.4 11 4 abnormal positive T cell selection 0.487096743597413 0.649854196673942 0.584804297774367 0.5 11.4 11 4 increased B-1 B cell number 0.487096743597413 0.649854196673942 0.584804297774367 0.5 11.4 11 4 decreased digestive secretion 0.503981831331386 0.669508574332082 0.584804297774367 0.5 11.4 11 4 abnormal pilomotor reflex 0.503981831331386 0.669508574332082 0.584804297774367 0.5 11.4 11 4 ear inflammation 0.503981831331386 0.669508574332082 0.584804297774367 0.5 11.4 11 4 increased growth rate 0.503981831331386 0.669508574332082 0.584804297774367 0.5 11.4 11 4 abnormal AMPA-mediated synaptic currents 0.503981831331386 0.669508574332082 0.584804297774367 0.5 11.4 11 4 increased circulating parathyroid hormone level 0.503981831331386 0.669508574332082 0.584804297774367 0.5 11.4 11 4 small thyroid gland 0.503981831331386 0.669508574332082 0.584804297774367 0.5 11.4 11 4 absent cochlear hair cells 0.503981831331386 0.669508574332082 0.584804297774367 0.5 11.4 11 4 increased placenta weight 0.503981831331386 0.669508574332082 0.584804297774367 0.5 11.4 11 4 abnormal B cell proliferation 0.503981831331386 0.669508574332082 0.584804297774367 0.5 11.4 11 4 abnormal amacrine cell morphology 0.503981831331386 0.669508574332082 0.584804297774367 0.5 11.4 11 4 abnormal palatine bone morphology 0.503981831331386 0.669508574332082 0.584804297774367 0.5 11.4 11 4 abnormal somatic nervous system physiology 0.503981831331386 0.669508574332082 0.584804297774367 0.5 11.4 11 4 decreased keratinocyte proliferation 0.503981831331386 0.669508574332082 0.584804297774367 0.5 11.4 11 4 decreased oligodendrocyte number 0.503981831331386 0.669508574332082 0.584804297774367 0.5 11.4 11 4 abnormal otic capsule morphology 0.523926259983569 0.692122449128586 0.584804297774367 0.5 11.4 11 4 abnormal optic nerve innervation 0.523926259983569 0.692122449128586 0.584804297774367 0.5 11.4 11 4 abnormal pituitary secretion 0.523926259983569 0.692122449128586 0.584804297774367 0.5 11.4 11 4 alcohol preference 0.523926259983569 0.692122449128586 0.584804297774367 0.5 11.4 11 4 primary sex reversal 0.523926259983569 0.692122449128586 0.584804297774367 0.5 11.4 11 4 abnormal bone healing 0.523926259983569 0.692122449128586 0.584804297774367 0.5 11.4 11 4 delayed dark adaptation 0.523926259983569 0.692122449128586 0.584804297774367 0.5 11.4 11 4 rickets 0.523926259983569 0.692122449128586 0.584804297774367 0.5 11.4 11 4 abnormal scala media morphology 0.523926259983569 0.692122449128586 0.584804297774367 0.5 11.4 11 4 intestinal edema 0.523926259983569 0.692122449128586 0.584804297774367 0.5 11.4 11 4 absent CD4-positive, alpha beta T cells 0.523926259983569 0.692122449128586 0.584804297774367 0.5 11.4 11 4 increased left ventricle diastolic pressure 0.523926259983569 0.692122449128586 0.584804297774367 0.5 11.4 11 4 decreased prolactin level 0.523926259983569 0.692122449128586 0.584804297774367 0.5 11.4 11 4 absent coat pigmentation 0.523926259983569 0.692122449128586 0.584804297774367 0.5 11.4 11 4 ascites 0.523926259983569 0.692122449128586 0.584804297774367 0.5 11.4 11 4 decreased thyroxine level 0.523926259983569 0.692122449128586 0.584804297774367 0.5 11.4 11 4 ventricular premature beat 0.523926259983569 0.692122449128586 0.584804297774367 0.5 11.4 11 4 umbilical hernia 0.523926259983569 0.692122449128586 0.584804297774367 0.5 11.4 11 4 common ventricle 0.523926259983569 0.692122449128586 0.584804297774367 0.5 11.4 11 4 abnormal body temperature homeostasis 0.467788716082299 0.627121763004429 0.565939643007452 0.483870967741935 11.4 11 4 increased susceptibility to induced arthritis 0.478258172838881 0.63926233473225 0.564638632333871 0.482758620689655 11.4 11 4 abnormal innervation pattern to muscle 0.514580884571617 0.683406273556805 0.55937802395809 0.478260869565217 11.4 11 4 abnormal associative learning 0.528835434638748 0.69823680661565 0.556956474070826 0.476190476190476 11.4 11 4 increased vasoconstriction 0.528835434638748 0.69823680661565 0.556956474070826 0.476190476190476 11.4 11 4 decreased susceptibility to induced arthritis 0.474482458684404 0.634385980100755 0.554025124207295 0.473684210526316 11.4 11 4 altered susceptibility to infection 0.544536720718352 0.717635082653944 0.554025124207295 0.473684210526316 11.4 11 4 abnormal ear morphology 0.544536720718352 0.717635082653944 0.554025124207295 0.473684210526316 11.4 11 4 maternal imprinting 0.544536720718352 0.717635082653944 0.554025124207295 0.473684210526316 11.4 11 4 abnormal bone remodeling 0.521613021849337 0.692122449128586 0.55040404496411 0.470588235294118 11.4 11 4 increased aggression towards mice 0.562025453277157 0.734456692948215 0.55040404496411 0.470588235294118 11.4 11 4 abnormal touch/ nociception 0.562025453277157 0.734456692948215 0.55040404496411 0.470588235294118 11.4 11 4 abnormal glutamate-mediated receptor currents 0.562025453277157 0.734456692948215 0.55040404496411 0.470588235294118 11.4 11 4 abnormal electroretinogram waveform feature 0.562025453277157 0.734456692948215 0.55040404496411 0.470588235294118 11.4 11 4 decreased susceptibility to parasitic infection 0.533287541766301 0.703928235682502 0.548254029163469 0.46875 11.4 11 4 increased susceptibility to parasitic infection 0.497392176699898 0.663411817448255 0.545817344589409 0.466666666666667 11.4 11 4 abnormal pain threshold 0.545716821775747 0.717635082653944 0.545817344589409 0.466666666666667 11.4 11 4 joint inflammation 0.581776006338527 0.748470553797303 0.545817344589409 0.466666666666667 11.4 11 4 abnormal zygomatic bone morphology 0.581776006338527 0.748470553797303 0.545817344589409 0.466666666666667 11.4 11 4 abnormal Muller cell morphology 0.581776006338527 0.748470553797303 0.545817344589409 0.466666666666667 11.4 11 4 decreased circulating progesterone level 0.559005997093221 0.731279209976012 0.543032562219055 0.464285714285714 11.4 11 4 short premaxilla 0.604474453113954 0.776467958750818 0.539819351791723 0.461538461538462 11.4 11 4 decreased alcohol consumption 0.604474453113954 0.776467958750818 0.539819351791723 0.461538461538462 11.4 11 4 abnormal retinal inner plexiform layer morphology 0.604474453113954 0.776467958750818 0.539819351791723 0.461538461538462 11.4 11 4 decreased endocochlear potential 0.604474453113954 0.776467958750818 0.539819351791723 0.461538461538462 11.4 11 4 small lymph nodes 0.58870819992052 0.756997491497696 0.53607060629317 0.458333333333333 11.4 11 4 decreased ovulation rate 0.58870819992052 0.756997491497696 0.53607060629317 0.458333333333333 11.4 11 4 impaired natural killer cell mediated cytotoxicity 0.579917069633757 0.747307048698498 0.53350567516258 0.456140350877193 11.4 11 4 abnormal oogenesis 0.605479753038779 0.777357876482045 0.53164027070397 0.454545454545455 11.4 11 4 abnormal channel response 0.605479753038779 0.777357876482045 0.53164027070397 0.454545454545455 11.4 11 4 decreased post-tetanic potentiation 0.631161477169961 0.791736850459041 0.53164027070397 0.454545454545455 11.4 11 4 variable body spotting 0.631161477169961 0.791736850459041 0.53164027070397 0.454545454545455 11.4 11 4 brain inflammation 0.623853117466683 0.786552917183417 0.52632386799693 0.45 11.4 11 4 abnormal circulating cytokine level 0.623853117466683 0.786552917183417 0.52632386799693 0.45 11.4 11 4 nuclear cataracts 0.623853117466683 0.786552917183417 0.52632386799693 0.45 11.4 11 4 abnormal food intake 0.622404926167206 0.786552917183417 0.525476325536388 0.449275362318841 11.4 11 4 decreased retinal photoreceptor cell number 0.624613604299872 0.786552917183417 0.524307301452881 0.448275862068966 11.4 11 4 increased retinal apoptosis 0.624613604299872 0.786552917183417 0.524307301452881 0.448275862068966 11.4 11 4 abnormal single cell response 0.64034004192815 0.803048073756629 0.519826042466104 0.444444444444444 11.4 11 4 decreased pancreatic beta cell number 0.654835733009809 0.820813245584228 0.516003792153853 0.441176470588235 11.4 11 4 decreased cytotoxic T cell cytolysis 0.654835733009809 0.820813245584228 0.516003792153853 0.441176470588235 11.4 11 4 abnormal stomach mucosa morphology 0.657212710059645 0.823585197115046 0.514627782041443 0.44 11.4 11 4 increased dopamine level 0.669474860968272 0.828068007435554 0.511703760552571 0.4375 11.4 11 4 abnormal pancreatic alpha cell morphology 0.666843732847103 0.828068007435554 0.511703760552571 0.4375 11.4 11 4 abnormal leukocyte adhesion 0.680884847683429 0.828068007435554 0.509829387803294 0.435897435897436 11.4 11 4 arrested T cell differentiation 0.684946437994791 0.828068007435554 0.506830391404451 0.433333333333333 11.4 11 4 abnormal antigen presentation 0.692507735251359 0.828068007435554 0.501260826663743 0.428571428571429 11.4 11 4 hypoalgesia 0.695116379587634 0.828068007435554 0.501260826663743 0.428571428571429 11.4 11 4 decreased vascular permeability 0.692507735251359 0.828068007435554 0.501260826663743 0.428571428571429 11.4 11 4 abnormal imprinting 0.692507735251359 0.828068007435554 0.501260826663743 0.428571428571429 11.4 11 4 abnormal hair cuticle 0.692507735251359 0.828068007435554 0.501260826663743 0.428571428571429 11.4 11 4 abnormal nail morphology 0.716613917528702 0.835909552099717 0.492466777073151 0.421052631578947 11.4 11 4 abnormal response to novelty 0.716613917528702 0.835909552099717 0.492466777073151 0.421052631578947 11.4 11 4 abnormal behavioral response to xenobiotic 0.716613917528702 0.835909552099717 0.492466777073151 0.421052631578947 11.4 11 4 abnormal T cell proliferation 0.739151764622899 0.860585075824695 0.490481023939792 0.419354838709677 11.4 11 4 abnormal esophagus morphology 0.722004081340371 0.841013885429254 0.487336914811972 0.416666666666667 11.4 11 4 abnormal gastrocnemius morphology 0.722004081340371 0.841013885429254 0.487336914811972 0.416666666666667 11.4 11 4 absent tail 0.722004081340371 0.841013885429254 0.487336914811972 0.416666666666667 11.4 11 4 increased fear-related response 0.722004081340371 0.841013885429254 0.487336914811972 0.416666666666667 11.4 11 4 impaired sperm capacitation 0.722004081340371 0.841013885429254 0.487336914811972 0.416666666666667 11.4 11 4 abnormal behavioral response to addictive substance 0.722004081340371 0.841013885429254 0.487336914811972 0.416666666666667 11.4 11 4 abnormal cellular extravasation 0.737326073574452 0.858660397011446 0.487336914811972 0.416666666666667 11.4 11 4 increased susceptibility to bacterial infection induced morbidity/mortality 0.80821034339514 0.924332519170304 0.487336914811972 0.416666666666667 11.4 11 4 abnormal circulating glucose level 0.755500790557506 0.874655215085968 0.48397597057189 0.413793103448276 11.4 11 4 abnormal heart rate 0.740216528546065 0.861623123424584 0.481603539343596 0.411764705882353 11.4 11 4 lactation failure 0.766328887859915 0.881907521883663 0.467843438219494 0.4 11.4 11 4 impaired conditioned place preference behavior 0.790734982584323 0.909573766094106 0.467843438219493 0.4 11.4 11 4 abnormal thymocyte activation 0.778454450903382 0.895654693164738 0.467843438219493 0.4 11.4 11 4 abnormal retinal cone cell morphology 0.809739285300737 0.925868293351222 0.457672928692983 0.391304347826087 11.4 11 4 abnormal sperm axoneme morphology 0.801343180635485 0.916689428296514 0.454847787157841 0.388888888888889 11.4 11 4 abnormal mast cell morphology 0.795460098981881 0.913198738541861 0.449849459826436 0.384615384615385 11.4 11 4 increased circulating adrenocorticotropin level 0.795460098981881 0.913198738541861 0.449849459826436 0.384615384615385 11.4 11 4 decreased follicle stimulating hormone level 0.795460098981881 0.913198738541861 0.449849459826436 0.384615384615385 11.4 11 4 total cataracts 0.795460098981881 0.913198738541861 0.449849459826436 0.384615384615385 11.4 11 4 abnormal gut flora balance 0.795460098981881 0.913198738541861 0.449849459826436 0.384615384615385 11.4 11 4 skeletal muscle necrosis 0.852655856609948 0.949197334221189 0.417717355553119 0.357142857142857 11.4 11 4 abnormal regulatory T cell physiology 0.903988592597874 1 0.406820381060429 0.347826086956522 11.4 11 4 increased susceptibility to fungal infection 0.903988592597874 1 0.406820381060429 0.347826086956522 11.4 11 4 decreased acute inflammation 0.94871760797865 1 0.374274750575595 0.32 11.4 11 4 decreased airway responsiveness 0.942316841749882 1 0.372148189492779 0.318181818181818 11.4 11 4 decreased chemically-elicited antinociception 0.935234723223879 1 0.369350082804863 0.315789473684211 11.4 11 4 increased circulating estradiol level 0.927546322856494 1 0.365502686108979 0.3125 11.4 11 4 elevated level of mitotic sister chromatid exchange 0.000235293027816975 0.00342275676429663 1.84096809312453 1 12.1 12 1 abnormal meiotic spindle morphology 0.000235293027816975 0.00342275676429663 1.84096809312453 1 12.1 12 1 abnormal mitotic spindle assembly checkpoint 0.000235293027816975 0.00342275676429663 1.84096809312453 1 12.1 12 1 abnormal macrophage activation involved in immune response 0.000235293027816975 0.00342275676429663 1.84096809312453 1 12.1 12 1 abnormal thymocyte activation 8.43706994505362e-10 4.82464631915422e-08 1.84096809312453 1 12.1 12 1 abnormal thrombopoiesis 1.02464476508503e-05 0.00023709803285107 1.84096809312453 1 12.1 12 1 lethality during fetal growth through weaning, complete penetrance 2.91256412397063e-05 0.000581927972560397 1.84096809312453 1 12.1 12 1 liver hyperplasia 8.27854611669996e-05 0.00141047147022542 1.84096809312453 1 12.1 12 1 abnormal lymph node cortex morphology 0.00190041420856687 0.0195170637736647 1.84096809312453 1 12.1 12 1 abnormal leukocyte tethering or rolling 0.00190041420856687 0.0195170637736647 1.84096809312453 1 12.1 12 1 abnormal T cell clonal deletion 0.00190041420856687 0.0195170637736647 1.84096809312453 1 12.1 12 1 increased transitional stage T1 B cell number 0.00190041420856687 0.0195170637736647 1.84096809312453 1 12.1 12 1 abnormal vertebral artery origin 0.00190041420856687 0.0195170637736647 1.84096809312453 1 12.1 12 1 abnormal pineal gland morphology 0.00540048169741786 0.0463230973183687 1.84096809312453 1 12.1 12 1 sinus inflammation 0.00540048169741786 0.0463230973183687 1.84096809312453 1 12.1 12 1 abnormal respiratory sounds 0.00540048169741786 0.0463230973183687 1.84096809312453 1 12.1 12 1 gastric polyps 0.00540048169741786 0.0463230973183687 1.84096809312453 1 12.1 12 1 abnormal T cell selection 0.00540048169741786 0.0463230973183687 1.84096809312453 1 12.1 12 1 increased placenta apoptosis 0.00540048169741786 0.0463230973183687 1.84096809312453 1 12.1 12 1 abnormal mismatch repair 0.00540048169741786 0.0463230973183687 1.84096809312453 1 12.1 12 1 aciduria 0.00540048169741786 0.0463230973183687 1.84096809312453 1 12.1 12 1 decreased DN3 thymocyte number 0.00540048169741786 0.0463230973183687 1.84096809312453 1 12.1 12 1 increased thyroid carcinoma incidence 0.00540048169741786 0.0463230973183687 1.84096809312453 1 12.1 12 1 increased renal carcinoma incidence 0.00540048169741786 0.0463230973183687 1.84096809312453 1 12.1 12 1 aorta hypoplasia 0.00540048169741786 0.0463230973183687 1.84096809312453 1 12.1 12 1 increased CD4-positive, alpha-beta memory T cell number 0.00540048169741786 0.0463230973183687 1.84096809312453 1 12.1 12 1 abnormal cytotoxic T cell physiology 2.59167614375599e-16 3.68388251862458e-14 1.75330294583288 0.952380952380952 12.1 12 1 increased effector memory CD4-positive, alpha-beta T cell number 2.33253774853532e-07 7.89413285643756e-06 1.73869208795094 0.944444444444444 12.1 12 1 increased regulatory T cell number 6.2745686483876e-07 1.88527847677572e-05 1.7326758523525 0.941176470588235 12.1 12 1 abnormal positive T cell selection 1.19532677902509e-05 0.000267871654308551 1.70947037218706 0.928571428571429 12.1 12 1 decreased response to antigen 1.19532677902509e-05 0.000267871654308551 1.70947037218706 0.928571428571429 12.1 12 1 increased number of Howell-Jolly bodies 0.000217917577128267 0.00326548176570219 1.67360735738594 0.909090909090909 12.1 12 1 increased fibroblast apoptosis 9.88380850918856e-11 6.64485774773149e-09 1.6683773343941 0.90625 12.1 12 1 increased incidence of induced tumors 2.23603790338056e-07 7.61937573240978e-06 1.66563779854124 0.904761904761905 12.1 12 1 spleen atrophy 5.7691812611162e-07 1.77170844284278e-05 1.65687128381208 0.9 12.1 12 1 absent inguinal lymph nodes 0.000565723840512639 0.00734850158368246 1.65687128381208 0.9 12.1 12 1 decreased transitional stage T2 B cell number 0.000565723840512639 0.00734850158368246 1.65687128381208 0.9 12.1 12 1 increased mortality induced by gamma-irradiation 1.68680765434256e-09 8.89792088611519e-08 1.65052311797372 0.896551724137931 12.1 12 1 increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 1.48105200031994e-06 4.00447483782159e-05 1.64718197805879 0.894736842105263 12.1 12 1 underdeveloped hair follicles 3.78108158472058e-06 9.40544044199244e-05 1.63641608277736 0.888888888888889 12.1 12 1 heart hyperplasia 0.00145535356101677 0.0163071710947262 1.63641608277736 0.888888888888889 12.1 12 1 abnormal leukopoiesis 0.00145535356101677 0.0163071710947262 1.63641608277736 0.888888888888889 12.1 12 1 absent cervical lymph nodes 0.00145535356101677 0.0163071710947262 1.63641608277736 0.888888888888889 12.1 12 1 increased myeloid cell number 0.00145535356101677 0.0163071710947262 1.63641608277736 0.888888888888889 12.1 12 1 abnormal ductus venosus valve topology 0.00145535356101677 0.0163071710947262 1.63641608277736 0.888888888888889 12.1 12 1 decreased platelet dense granule number 0.00145535356101677 0.0163071710947262 1.63641608277736 0.888888888888889 12.1 12 1 increased thymocyte apoptosis 2.78342902647802e-08 1.18355208604514e-06 1.62854869776401 0.884615384615385 12.1 12 1 decreased double-positive T cell number 6.46242674661768e-28 2.67921442203525e-25 1.62005192194959 0.88 12.1 12 1 abnormal T cell subpopulation ratio 5.38865816575253e-10 3.20744183841083e-08 1.61782044547307 0.878787878787879 12.1 12 1 increased sensitivity to skin irradiation 0.00370266130701962 0.033799522940225 1.61084708148396 0.875 12.1 12 1 colon polyps 0.00370266130701962 0.033799522940225 1.61084708148396 0.875 12.1 12 1 abnormal NK cell morphology 0.00370266130701962 0.033799522940225 1.61084708148396 0.875 12.1 12 1 abnormal base-excision repair 0.00370266130701962 0.033799522940225 1.61084708148396 0.875 12.1 12 1 abnormal cerebellum deep nucleus morphology 0.00370266130701962 0.033799522940225 1.61084708148396 0.875 12.1 12 1 pleural effusion 0.00370266130701962 0.033799522940225 1.61084708148396 0.875 12.1 12 1 small thymus medulla 0.00370266130701962 0.033799522940225 1.61084708148396 0.875 12.1 12 1 increased brain apoptosis 0.00370266130701962 0.033799522940225 1.61084708148396 0.875 12.1 12 1 increased adenoma incidence 1.09337837600886e-06 3.12618242565753e-05 1.58992698951664 0.863636363636364 12.1 12 1 testis degeneration 0.000149784968420295 0.00235072623940369 1.5779726512496 0.857142857142857 12.1 12 1 asymmetric rib joints 0.00929061508366425 0.0714386553960273 1.5779726512496 0.857142857142857 12.1 12 1 skin photosensitivity 0.00929061508366425 0.0714386553960273 1.5779726512496 0.857142857142857 12.1 12 1 decreased activated T cell number 0.00929061508366425 0.0714386553960273 1.5779726512496 0.857142857142857 12.1 12 1 abnormal gastrulation movements 0.00929061508366425 0.0714386553960273 1.5779726512496 0.857142857142857 12.1 12 1 aorta coarctation 0.00929061508366425 0.0714386553960273 1.5779726512496 0.857142857142857 12.1 12 1 abnormal negative T cell selection 0.00929061508366425 0.0714386553960273 1.5779726512496 0.857142857142857 12.1 12 1 absent popliteal lymph nodes 0.00929061508366425 0.0714386553960273 1.5779726512496 0.857142857142857 12.1 12 1 heart hemorrhage 0.00929061508366425 0.0714386553960273 1.5779726512496 0.857142857142857 12.1 12 1 increased tumor latency 0.00929061508366425 0.0714386553960273 1.5779726512496 0.857142857142857 12.1 12 1 abnormal sperm annulus morphology 0.00929061508366425 0.0714386553960273 1.5779726512496 0.857142857142857 12.1 12 1 decreased DN2 thymocyte number 0.00929061508366425 0.0714386553960273 1.5779726512496 0.857142857142857 12.1 12 1 decreased DN4 thymocyte number 0.00929061508366425 0.0714386553960273 1.5779726512496 0.857142857142857 12.1 12 1 decreased T-helper 17 cell number 0.00929061508366425 0.0714386553960273 1.5779726512496 0.857142857142857 12.1 12 1 decreased CD8-positive, naive alpha-beta T cell number 0.00929061508366425 0.0714386553960273 1.5779726512496 0.857142857142857 12.1 12 1 absent connection between subcutaneous lymph vessels and lymph sac 0.00929061508366425 0.0714386553960273 1.5779726512496 0.857142857142857 12.1 12 1 decreased cytotoxic T cell cytolysis 2.42228733756314e-09 1.20508795043766e-07 1.57023749119445 0.852941176470588 12.1 12 1 abnormal T cell activation 9.64721180916876e-19 1.71410281252195e-16 1.56731067387629 0.851351351351351 12.1 12 1 increased cellular sensitivity to gamma-irradiation 2.33051245967347e-12 1.87004830433476e-10 1.56678135585066 0.851063829787234 12.1 12 1 abnormal telomere length 0.000367460356628822 0.00510646724644801 1.55774223264383 0.846153846153846 12.1 12 1 absent hypoglossal nerve 0.000367460356628822 0.00510646724644801 1.55774223264383 0.846153846153846 12.1 12 1 increased B cell derived lymphoma incidence 1.60719043833726e-12 1.37858145357377e-10 1.5464131982246 0.84 12.1 12 1 abnormal CD8-positive, alpha beta T cell morphology 3.44116367355901e-08 1.40326141606197e-06 1.5440377555238 0.838709677419355 12.1 12 1 arrested T cell differentiation 8.2428473142523e-08 3.13039430445841e-06 1.53414007760377 0.833333333333333 12.1 12 1 abnormal Peyer's patch follicle morphology 3.86560564133584e-05 0.000725712757194181 1.53414007760377 0.833333333333333 12.1 12 1 decreased cellular sensitivity to gamma-irradiation 3.86560564133584e-05 0.000725712757194181 1.53414007760377 0.833333333333333 12.1 12 1 absent inner cell mass 3.86560564133584e-05 0.000725712757194181 1.53414007760377 0.833333333333333 12.1 12 1 increased gastrointestinal tumor incidence 3.86560564133584e-05 0.000725712757194181 1.53414007760377 0.833333333333333 12.1 12 1 abnormal hypoglossal nerve topology 3.86560564133584e-05 0.000725712757194181 1.53414007760377 0.833333333333333 12.1 12 1 abnormal thymus involution 0.000890967258396892 0.0106042155754176 1.53414007760377 0.833333333333333 12.1 12 1 interstitial pneumonia 0.000890967258396892 0.0106042155754176 1.53414007760377 0.833333333333333 12.1 12 1 altered tumor susceptibility 0.000890967258396892 0.0106042155754176 1.53414007760377 0.833333333333333 12.1 12 1 increased osteosarcoma incidence 0.000890967258396892 0.0106042155754176 1.53414007760377 0.833333333333333 12.1 12 1 abnormal vitelline vein connection 0.000890967258396892 0.0106042155754176 1.53414007760377 0.833333333333333 12.1 12 1 echinocytosis 0.0229008191416728 0.139965080134917 1.53414007760377 0.833333333333333 12.1 12 1 epidermal necrosis 0.0229008191416728 0.139965080134917 1.53414007760377 0.833333333333333 12.1 12 1 absent ectoplacental cone 0.0229008191416728 0.139965080134917 1.53414007760377 0.833333333333333 12.1 12 1 abnormal lymph organ size 0.0229008191416728 0.139965080134917 1.53414007760377 0.833333333333333 12.1 12 1 abnormal cervical lymph node morphology 0.0229008191416728 0.139965080134917 1.53414007760377 0.833333333333333 12.1 12 1 decreased liver function 0.0229008191416728 0.139965080134917 1.53414007760377 0.833333333333333 12.1 12 1 enlarged pancreas 0.0229008191416728 0.139965080134917 1.53414007760377 0.833333333333333 12.1 12 1 rheumatoid arthritis 0.0229008191416728 0.139965080134917 1.53414007760377 0.833333333333333 12.1 12 1 abnormal cholesterol level 0.0229008191416728 0.139965080134917 1.53414007760377 0.833333333333333 12.1 12 1 absent parietal bone 0.0229008191416728 0.139965080134917 1.53414007760377 0.833333333333333 12.1 12 1 decreased prostate gland weight 0.0229008191416728 0.139965080134917 1.53414007760377 0.833333333333333 12.1 12 1 impaired granulocyte bactericidal activity 0.0229008191416728 0.139965080134917 1.53414007760377 0.833333333333333 12.1 12 1 abnormal heart size 0.0229008191416728 0.139965080134917 1.53414007760377 0.833333333333333 12.1 12 1 decreased platelet ADP level 0.0229008191416728 0.139965080134917 1.53414007760377 0.833333333333333 12.1 12 1 absent brachial lymph nodes 0.0229008191416728 0.139965080134917 1.53414007760377 0.833333333333333 12.1 12 1 delayed chorioallantoic fusion 0.0229008191416728 0.139965080134917 1.53414007760377 0.833333333333333 12.1 12 1 decreased DN1 thymic pro-T cell number 0.0229008191416728 0.139965080134917 1.53414007760377 0.833333333333333 12.1 12 1 myocardium hypoplasia 0.0229008191416728 0.139965080134917 1.53414007760377 0.833333333333333 12.1 12 1 absent third pharyngeal arch 0.0229008191416728 0.139965080134917 1.53414007760377 0.833333333333333 12.1 12 1 abnormal intestinal enteroendocrine cell morphology 0.0229008191416728 0.139965080134917 1.53414007760377 0.833333333333333 12.1 12 1 thymus cortex atrophy 0.0229008191416728 0.139965080134917 1.53414007760377 0.833333333333333 12.1 12 1 increased CD11b-high dendritic cell number 0.0229008191416728 0.139965080134917 1.53414007760377 0.833333333333333 12.1 12 1 absent thymus corticomedullary boundary 0.0229008191416728 0.139965080134917 1.53414007760377 0.833333333333333 12.1 12 1 increased effector memory T-helper cell number 0.0229008191416728 0.139965080134917 1.53414007760377 0.833333333333333 12.1 12 1 abnormal embryonic-extraembryonic boundary morphology 9.2214645240771e-05 0.00154467292953817 1.51609137080844 0.823529411764706 12.1 12 1 lymphoid hyperplasia 4.64098854700091e-07 1.45213320888865e-05 1.51222379078086 0.821428571428571 12.1 12 1 subcutaneous edema 4.64098854700091e-07 1.45213320888865e-05 1.51222379078086 0.821428571428571 12.1 12 1 abnormal erythropoiesis 9.41514725996717e-23 2.7553151540198e-20 1.50784053341628 0.819047619047619 12.1 12 1 increased activated T cell number 9.9122200821016e-06 0.000230435957516147 1.50624662164734 0.818181818181818 12.1 12 1 abnormal proximal-distal axis patterning 0.00213085202574232 0.0215467252603009 1.50624662164734 0.818181818181818 12.1 12 1 loss of cortex neurons 0.00213085202574232 0.0215467252603009 1.50624662164734 0.818181818181818 12.1 12 1 abnormal dorsal-ventral polarity of the somites 0.00213085202574232 0.0215467252603009 1.50624662164734 0.818181818181818 12.1 12 1 thin hypoglossal nerve 0.00213085202574232 0.0215467252603009 1.50624662164734 0.818181818181818 12.1 12 1 reduced sympathetic cervical ganglion size 0.00213085202574232 0.0215467252603009 1.50624662164734 0.818181818181818 12.1 12 1 increased T cell derived lymphoma incidence 3.29744451207237e-11 2.41246859522942e-09 1.50283109642819 0.816326530612245 12.1 12 1 intraventricular hemorrhage 0.000217595138983595 0.00326548176570219 1.49578657566368 0.8125 12.1 12 1 increased intestinal adenocarcinoma incidence 0.000217595138983595 0.00326548176570219 1.49578657566368 0.8125 12.1 12 1 decreased liver cholesterol level 0.000217595138983595 0.00326548176570219 1.49578657566368 0.8125 12.1 12 1 abnormal chromosome morphology 1.37194713994107e-08 6.09414019750609e-07 1.49267683226313 0.810810810810811 12.1 12 1 abnormal cell cycle 1.03773977958074e-23 3.22672212713386e-21 1.48878289270071 0.808695652173913 12.1 12 1 abnormal T cell proliferation 2.82498624838079e-07 9.18582129783949e-06 1.48465168800365 0.806451612903226 12.1 12 1 abnormal lysosome morphology 3.17861644069554e-08 1.32887536071095e-06 1.48300207501698 0.805555555555556 12.1 12 1 abnormal lymphocyte physiology 4.1187406616059e-10 2.52972034462831e-08 1.48077868360016 0.804347826086957 12.1 12 1 embryonic lethality between implantation and placentation, complete penetrance 4.1187406616059e-10 2.52972034462831e-08 1.48077868360016 0.804347826086957 12.1 12 1 increased double-negative T cell number 6.29453393539735e-13 5.69369205974579e-11 1.47881043546069 0.80327868852459 12.1 12 1 decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 5.86972301259915e-06 0.000143146431312161 1.47277447449962 0.8 12.1 12 1 increased skin tumor incidence 5.38216210242841e-05 0.000963174692790695 1.47277447449962 0.8 12.1 12 1 delayed intramembranous bone ossification 0.000507163748903811 0.00671047779467144 1.47277447449962 0.8 12.1 12 1 heterochrony 0.000507163748903811 0.00671047779467144 1.47277447449962 0.8 12.1 12 1 abnormal gas homeostasis 0.00501387244303332 0.0443055335774259 1.47277447449962 0.8 12.1 12 1 absent axillary lymph nodes 0.00501387244303332 0.0443055335774259 1.47277447449962 0.8 12.1 12 1 acanthocytosis 0.00501387244303332 0.0443055335774259 1.47277447449962 0.8 12.1 12 1 abnormal inferior vena cava valve morphology 0.00501387244303332 0.0443055335774259 1.47277447449962 0.8 12.1 12 1 increased fatty acid oxidation 0.00501387244303332 0.0443055335774259 1.47277447449962 0.8 12.1 12 1 abnormal apoptosis 2.85588659215544e-11 2.15273269635959e-09 1.46595607415472 0.796296296296296 12.1 12 1 abnormal inner cell mass apoptosis 1.34445223925987e-05 0.000297273328458571 1.45743307372359 0.791666666666667 12.1 12 1 abnormal cell morphology 1.27023287883125e-21 2.8724584419025e-19 1.45339586299305 0.789473684210526 12.1 12 1 decreased tumor incidence 0.000123436620332737 0.00196197184075198 1.45339586299305 0.789473684210526 12.1 12 1 increased liver adenoma incidence 0.000123436620332737 0.00196197184075198 1.45339586299305 0.789473684210526 12.1 12 1 increased hemangioma incidence 0.00116560344672675 0.013580508542074 1.44647493031213 0.785714285714286 12.1 12 1 lysosomal protein accumulation 0.00116560344672675 0.013580508542074 1.44647493031213 0.785714285714286 12.1 12 1 abnormal thymus cortex morphology 0.000279669706136714 0.00397994714595785 1.43186407243019 0.777777777777778 12.1 12 1 abnormal redox activity 0.000279669706136714 0.00397994714595785 1.43186407243019 0.777777777777778 12.1 12 1 increased effector memory CD8-positive, alpha-beta T cell number 0.000279669706136714 0.00397994714595785 1.43186407243019 0.777777777777778 12.1 12 1 abnormal aerobic respiration 0.000279669706136714 0.00397994714595785 1.43186407243019 0.777777777777778 12.1 12 1 crypts of Lieberkuhn abscesses 0.0115682384180296 0.085388703456524 1.43186407243019 0.777777777777778 12.1 12 1 multifocal hepatic necrosis 0.0115682384180296 0.085388703456524 1.43186407243019 0.777777777777778 12.1 12 1 decreased level of surface class I molecules 0.0115682384180296 0.085388703456524 1.43186407243019 0.777777777777778 12.1 12 1 increased pheochromocytoma incidence 0.0115682384180296 0.085388703456524 1.43186407243019 0.777777777777778 12.1 12 1 abnormal gut-associated lymphoid tissue morphology 0.0115682384180296 0.085388703456524 1.43186407243019 0.777777777777778 12.1 12 1 genetic imprinting 0.0115682384180296 0.085388703456524 1.43186407243019 0.777777777777778 12.1 12 1 increased neuronal precursor cell number 0.0115682384180296 0.085388703456524 1.43186407243019 0.777777777777778 12.1 12 1 decreased transitional stage T1 B cell number 0.0115682384180296 0.085388703456524 1.43186407243019 0.777777777777778 12.1 12 1 abnormal telomere morphology 0.0115682384180296 0.085388703456524 1.43186407243019 0.777777777777778 12.1 12 1 decreased effector memory CD4-positive, alpha-beta T cell number 0.0115682384180296 0.085388703456524 1.43186407243019 0.777777777777778 12.1 12 1 abnormal oxidative phosphorylation 0.0115682384180296 0.085388703456524 1.43186407243019 0.777777777777778 12.1 12 1 abnormal infrahyoid muscle connection 0.0115682384180296 0.085388703456524 1.43186407243019 0.777777777777778 12.1 12 1 symmetric azygos veins 0.0115682384180296 0.085388703456524 1.43186407243019 0.777777777777778 12.1 12 1 decreased T cell proliferation 3.96152879121358e-26 1.51604659509904e-23 1.43048196425217 0.777027027027027 12.1 12 1 thymus hypoplasia 2.8306384444886e-24 1.00588759009506e-21 1.42741728959655 0.77536231884058 12.1 12 1 inner cell mass degeneration 1.91648121199698e-06 5.07153937749202e-05 1.42526562048351 0.774193548387097 12.1 12 1 abnormal mitochondrial ATP synthesis coupled electron transport 1.91648121199698e-06 5.07153937749202e-05 1.42526562048351 0.774193548387097 12.1 12 1 abnormal T cell differentiation 6.72255615916399e-18 9.83668143877671e-16 1.42173773528429 0.772277227722772 12.1 12 1 decreased B cell proliferation 2.68978104711069e-14 2.78784598111994e-12 1.42150700861514 0.772151898734177 12.1 12 1 embryonic lethality between implantation and somite formation, complete penetrance 3.15905404712392e-41 3.1432587768883e-38 1.42017538612464 0.771428571428571 12.1 12 1 embryonic lethality between somite formation and embryo turning, complete penetrance 8.7545900530951e-13 7.64106763406107e-11 1.42017538612464 0.771428571428571 12.1 12 1 vertebral transformation 3.67039021782444e-09 1.73906584130253e-07 1.41907957178349 0.770833333333333 12.1 12 1 pale liver 2.27856353614604e-13 2.17997184467819e-11 1.41804299064997 0.77027027027027 12.1 12 1 decreased Peyer's patch number 1.69697011594906e-05 0.000362335893856077 1.41612930240348 0.769230769230769 12.1 12 1 increased pituitary adenoma incidence 0.00263599026429045 0.0261236086949103 1.41612930240348 0.769230769230769 12.1 12 1 lymphoid hypoplasia 0.00263599026429045 0.0261236086949103 1.41612930240348 0.769230769230769 12.1 12 1 abnormal tail bud morphology 0.00263599026429045 0.0261236086949103 1.41612930240348 0.769230769230769 12.1 12 1 abnormal double-strand DNA break repair 3.15588919509154e-08 1.32887536071095e-06 1.41283597844441 0.767441860465116 12.1 12 1 abnormal ectoplacental cone morphology 0.000625081743647777 0.00805642920893184 1.4077991300364 0.764705882352941 12.1 12 1 abnormal hematopoietic system physiology 0.000151772126186225 0.00237442241439141 1.40264235666631 0.761904761904762 12.1 12 1 increased cellular sensitivity to ionizing radiation 3.74313870959304e-05 0.000716235195393283 1.39913575077464 0.76 12.1 12 1 abnormal preimplantation embryo development 3.74313870959304e-05 0.000716235195393283 1.39913575077464 0.76 12.1 12 1 embryonic lethality before implantation, complete penetrance 1.29559886856514e-20 2.80243668309198e-18 1.39913575077464 0.76 12.1 12 1 spleen hyperplasia 6.22846666863534e-13 5.69369205974579e-11 1.39913575077464 0.76 12.1 12 1 abnormal embryonic erythropoiesis 9.3345702871877e-06 0.000219054184805466 1.3965964844393 0.758620689655172 12.1 12 1 abnormal CD8-positive, alpha-beta T cell physiology 9.3345702871877e-06 0.000219054184805466 1.3965964844393 0.758620689655172 12.1 12 1 disorganized yolk sac vascular plexus 0.00137586957866446 0.0157322855906284 1.3807260698434 0.75 12.1 12 1 blepharitis 0.00137586957866446 0.0157322855906284 1.3807260698434 0.75 12.1 12 1 decreased fibroblast apoptosis 0.00137586957866446 0.0157322855906284 1.3807260698434 0.75 12.1 12 1 enlarged pituitary gland 0.0260544764135981 0.151322430468319 1.3807260698434 0.75 12.1 12 1 abnormal atrial thrombosis 0.0260544764135981 0.151322430468319 1.3807260698434 0.75 12.1 12 1 preneoplasia 0.0260544764135981 0.151322430468319 1.3807260698434 0.75 12.1 12 1 abnormal platelet shape 0.0260544764135981 0.151322430468319 1.3807260698434 0.75 12.1 12 1 binucleate 0.0260544764135981 0.151322430468319 1.3807260698434 0.75 12.1 12 1 lymph node inflammation 0.0260544764135981 0.151322430468319 1.3807260698434 0.75 12.1 12 1 abnormal extraembryonic tissue physiology 0.0260544764135981 0.151322430468319 1.3807260698434 0.75 12.1 12 1 absent interparietal bone 0.0260544764135981 0.151322430468319 1.3807260698434 0.75 12.1 12 1 abnormal kidney epithelium morphology 0.0260544764135981 0.151322430468319 1.3807260698434 0.75 12.1 12 1 accumulation of giant lysosomes in kidney/renal tubule cells 0.0260544764135981 0.151322430468319 1.3807260698434 0.75 12.1 12 1 abnormal choroid pigmentation 0.0260544764135981 0.151322430468319 1.3807260698434 0.75 12.1 12 1 increased caudal vertebrae number 0.0260544764135981 0.151322430468319 1.3807260698434 0.75 12.1 12 1 abnormal hepatic vein morphology 0.0260544764135981 0.151322430468319 1.3807260698434 0.75 12.1 12 1 myocardial trabeculae hypoplasia 0.0260544764135981 0.151322430468319 1.3807260698434 0.75 12.1 12 1 delayed suture closure 0.0260544764135981 0.151322430468319 1.3807260698434 0.75 12.1 12 1 lung situs inversus 0.0260544764135981 0.151322430468319 1.3807260698434 0.75 12.1 12 1 absent hypoglossal canal 0.0260544764135981 0.151322430468319 1.3807260698434 0.75 12.1 12 1 abnormal umbilical vein topology 0.0260544764135981 0.151322430468319 1.3807260698434 0.75 12.1 12 1 increased tumor incidence 1.59602784303161e-19 3.05393789195472e-17 1.3807260698434 0.75 12.1 12 1 premature aging 2.03048042447504e-05 0.000424438660158123 1.3807260698434 0.75 12.1 12 1 increased hemangiosarcoma incidence 8.16450351362827e-05 0.00139582147698628 1.3807260698434 0.75 12.1 12 1 abnormal Peyer's patch T cell area morphology 0.000332281618258097 0.00465662267840572 1.3807260698434 0.75 12.1 12 1 absent ductus venosus valve 0.000332281618258097 0.00465662267840572 1.3807260698434 0.75 12.1 12 1 myocarditis 0.0058505063277786 0.0490004528294588 1.3807260698434 0.75 12.1 12 1 abnormal embryonic growth/weight/body size 0.0058505063277786 0.0490004528294588 1.3807260698434 0.75 12.1 12 1 abnormal vascular endothelial cell development 0.0058505063277786 0.0490004528294588 1.3807260698434 0.75 12.1 12 1 abnormal B cell proliferation 0.0058505063277786 0.0490004528294588 1.3807260698434 0.75 12.1 12 1 decreased red blood cell distribution width 0.0058505063277786 0.0490004528294588 1.3807260698434 0.75 12.1 12 1 increased fibrosarcoma incidence 0.0058505063277786 0.0490004528294588 1.3807260698434 0.75 12.1 12 1 prenatal growth retardation 0.0058505063277786 0.0490004528294588 1.3807260698434 0.75 12.1 12 1 abnormal B cell differentiation 1.60049392597631e-14 1.73096897428959e-12 1.37566846519196 0.747252747252747 12.1 12 1 abnormal embryo turning 3.02573005131848e-09 1.46145699080674e-07 1.37235803305647 0.745454545454545 12.1 12 1 impaired hematopoiesis 1.17588965997538e-08 5.27031626880855e-07 1.37170171644573 0.745098039215686 12.1 12 1 abnormal cell nucleus morphology 4.58134115481386e-08 1.80890255914278e-06 1.37093368636933 0.74468085106383 12.1 12 1 small liver 1.9425447350292e-12 1.58428853389677e-10 1.36892499232337 0.743589743589744 12.1 12 1 increased embryonic tissue cell apoptosis 1.9425447350292e-12 1.58428853389677e-10 1.36892499232337 0.743589743589744 12.1 12 1 decreased B-1 B cell number 7.02120132681136e-07 2.05473391769921e-05 1.36892499232337 0.743589743589744 12.1 12 1 increased carcinoma incidence 2.76581765448697e-06 7.02037899544525e-05 1.36757629774965 0.742857142857143 12.1 12 1 decreased double-negative T cell number 1.09553471296185e-05 0.000252328018378944 1.36587955296336 0.741935483870968 12.1 12 1 decreased bone marrow cell number 1.58950760545426e-11 1.21658466725153e-09 1.36181201409212 0.73972602739726 12.1 12 1 failure to gastrulate 9.7649486486985e-08 3.59856440942778e-06 1.36071554709204 0.739130434782609 12.1 12 1 increased T cell proliferation 3.94576798166666e-16 5.45283214133101e-14 1.35921943324147 0.738317757009346 12.1 12 1 decreased neuron apoptosis 1.49568471378137e-06 4.02217916273639e-05 1.35650280546018 0.736842105263158 12.1 12 1 increased malignant tumor incidence 0.000717122346387846 0.00912451067334919 1.35650280546018 0.736842105263158 12.1 12 1 macrocytosis 0.00297631261573984 0.0288638504158006 1.35004326829132 0.733333333333333 12.1 12 1 absent egg cylinders 0.00297631261573984 0.0288638504158006 1.35004326829132 0.733333333333333 12.1 12 1 abnormal lymph node B cell domain morphology 0.00297631261573984 0.0288638504158006 1.35004326829132 0.733333333333333 12.1 12 1 abnormal placenta size 0.00297631261573984 0.0288638504158006 1.35004326829132 0.733333333333333 12.1 12 1 abnormal trophectoderm morphology 0.00297631261573984 0.0288638504158006 1.35004326829132 0.733333333333333 12.1 12 1 immune system phenotype 0.00297631261573984 0.0288638504158006 1.35004326829132 0.733333333333333 12.1 12 1 abnormal dendritic cell morphology 0.00297631261573984 0.0288638504158006 1.35004326829132 0.733333333333333 12.1 12 1 decreased thymocyte apoptosis 0.00297631261573984 0.0288638504158006 1.35004326829132 0.733333333333333 12.1 12 1 increased B cell proliferation 4.03968777232807e-09 1.89598553465398e-07 1.34172250854839 0.728813559322034 12.1 12 1 increased skin papilloma incidence 0.000374013423669399 0.00514999261270225 1.33888588590875 0.727272727272727 12.1 12 1 abnormal lysosome physiology 0.000374013423669399 0.00514999261270225 1.33888588590875 0.727272727272727 12.1 12 1 embryonic lethality before implantation, incomplete penetrance 0.000374013423669399 0.00514999261270225 1.33888588590875 0.727272727272727 12.1 12 1 abnormal sphenoid bone morphology 0.0127019268891427 0.0914501972119895 1.33888588590875 0.727272727272727 12.1 12 1 delayed hepatic development 0.0127019268891427 0.0914501972119895 1.33888588590875 0.727272727272727 12.1 12 1 vasculitis 0.0127019268891427 0.0914501972119895 1.33888588590875 0.727272727272727 12.1 12 1 extramedullary hematopoiesis 4.19327305839111e-15 4.85151941058041e-13 1.33730701104329 0.726415094339623 12.1 12 1 preweaning lethality, complete penetrance 2.95325316742526e-97 1.46924345079407e-93 1.3359457648755 0.725675675675676 12.1 12 1 abnormal trophoblast giant cell morphology 6.61038937700292e-06 0.000160422864149217 1.3295880672566 0.722222222222222 12.1 12 1 abnormal megakaryocyte differentiation 0.00152315304117654 0.0167647928757816 1.3295880672566 0.722222222222222 12.1 12 1 abnormal thymus medulla morphology 0.00152315304117654 0.0167647928757816 1.3295880672566 0.722222222222222 12.1 12 1 decreased tumor latency 0.00152315304117654 0.0167647928757816 1.3295880672566 0.722222222222222 12.1 12 1 impaired leukocyte tethering or rolling 0.00152315304117654 0.0167647928757816 1.3295880672566 0.722222222222222 12.1 12 1 embryonic growth arrest 5.13319741401494e-30 2.55376571347243e-27 1.32646172648711 0.720524017467249 12.1 12 1 abnormal definitive hematopoiesis 4.80231082033475e-13 4.5078294964463e-11 1.32628884128326 0.720430107526882 12.1 12 1 ruffled hair 0.000195337272954331 0.0029993917683574 1.32549702704966 0.72 12.1 12 1 decreased embryo size 5.6171278096921e-61 1.39726054266091e-57 1.32488080342016 0.719665271966527 12.1 12 1 abnormal developmental patterning 1.28473719310448e-11 9.98682427452314e-10 1.3245989938335 0.719512195121951 12.1 12 1 impaired natural killer cell mediated cytotoxicity 1.74630144019262e-08 7.55465188257242e-07 1.32420511961589 0.719298245614035 12.1 12 1 abnormal osteoclast physiology 2.45148344222355e-09 1.20753763614477e-07 1.32319581693326 0.71875 12.1 12 1 failure of primitive streak formation 2.59321165261633e-05 0.000528738851301896 1.32319581693326 0.71875 12.1 12 1 abnormal spleen white pulp morphology 1.86926413554974e-06 4.99977907223652e-05 1.31497720937466 0.714285714285714 12.1 12 1 embryonic lethality at implantation, complete penetrance 0.00078355534843778 0.00969698472258197 1.31497720937466 0.714285714285714 12.1 12 1 absent segment of posterior cerebral artery 0.00078355534843778 0.00969698472258197 1.31497720937466 0.714285714285714 12.1 12 1 increased sarcoma incidence 2.58148298900617e-07 8.61938112101052e-06 1.31497720937466 0.714285714285714 12.1 12 1 failure of blastocyst to hatch from the zona pellucida 0.000102185393695473 0.00168335209812906 1.31497720937466 0.714285714285714 12.1 12 1 abnormal mitotic spindle morphology 0.000102185393695473 0.00168335209812906 1.31497720937466 0.714285714285714 12.1 12 1 abnormal spleen periarteriolar lymphoid sheath morphology 0.00631195730819971 0.0519804544398945 1.31497720937466 0.714285714285714 12.1 12 1 vascular smooth muscle hypoplasia 0.00631195730819971 0.0519804544398945 1.31497720937466 0.714285714285714 12.1 12 1 abnormal maternal decidual layer morphology 0.00631195730819971 0.0519804544398945 1.31497720937466 0.714285714285714 12.1 12 1 increased stomach tumor incidence 0.00631195730819971 0.0519804544398945 1.31497720937466 0.714285714285714 12.1 12 1 multiple persisting craniopharyngeal ducts 0.00631195730819971 0.0519804544398945 1.31497720937466 0.714285714285714 12.1 12 1 abnormal vitelline vein topology 0.00631195730819971 0.0519804544398945 1.31497720937466 0.714285714285714 12.1 12 1 broad head 0.0569263292866944 0.253090695443525 1.31497720937466 0.714285714285714 12.1 12 1 polyphalangy 0.0569263292866944 0.253090695443525 1.31497720937466 0.714285714285714 12.1 12 1 mammary gland hyperplasia 0.0569263292866944 0.253090695443525 1.31497720937466 0.714285714285714 12.1 12 1 absent epidermis stratum corneum 0.0569263292866944 0.253090695443525 1.31497720937466 0.714285714285714 12.1 12 1 abnormal circulating alanine transaminase level 0.0569263292866944 0.253090695443525 1.31497720937466 0.714285714285714 12.1 12 1 abnormal hypersensitivity reaction 0.0569263292866944 0.253090695443525 1.31497720937466 0.714285714285714 12.1 12 1 abnormal lymph node primary follicle morphology 0.0569263292866944 0.253090695443525 1.31497720937466 0.714285714285714 12.1 12 1 detached tectorial membrane 0.0569263292866944 0.253090695443525 1.31497720937466 0.714285714285714 12.1 12 1 decreased cardiomyocyte apoptosis 0.0569263292866944 0.253090695443525 1.31497720937466 0.714285714285714 12.1 12 1 increased cell nucleus count 0.0569263292866944 0.253090695443525 1.31497720937466 0.714285714285714 12.1 12 1 abnormal optic tract morphology 0.0569263292866944 0.253090695443525 1.31497720937466 0.714285714285714 12.1 12 1 abnormal cochlear nerve compound action potential 0.0569263292866944 0.253090695443525 1.31497720937466 0.714285714285714 12.1 12 1 increased chronic myelocytic leukemia incidence 0.0569263292866944 0.253090695443525 1.31497720937466 0.714285714285714 12.1 12 1 decreased tidal volume 0.0569263292866944 0.253090695443525 1.31497720937466 0.714285714285714 12.1 12 1 abnormal uterus physiology 0.0569263292866944 0.253090695443525 1.31497720937466 0.714285714285714 12.1 12 1 abnormal spinal cord central canal morphology 0.0569263292866944 0.253090695443525 1.31497720937466 0.714285714285714 12.1 12 1 increased DN3 thymocyte number 0.0569263292866944 0.253090695443525 1.31497720937466 0.714285714285714 12.1 12 1 arteritis 0.0569263292866944 0.253090695443525 1.31497720937466 0.714285714285714 12.1 12 1 decreased brain cholesterol level 0.0569263292866944 0.253090695443525 1.31497720937466 0.714285714285714 12.1 12 1 increased compact bone volume 0.0569263292866944 0.253090695443525 1.31497720937466 0.714285714285714 12.1 12 1 embryonic lethality at implantation, incomplete penetrance 0.0569263292866944 0.253090695443525 1.31497720937466 0.714285714285714 12.1 12 1 increased circulating lactate dehydrogenase level 0.0569263292866944 0.253090695443525 1.31497720937466 0.714285714285714 12.1 12 1 small tail bud 0.0569263292866944 0.253090695443525 1.31497720937466 0.714285714285714 12.1 12 1 decreased areal bone mineral density 0.0569263292866944 0.253090695443525 1.31497720937466 0.714285714285714 12.1 12 1 ductus venosus stenosis 0.0569263292866944 0.253090695443525 1.31497720937466 0.714285714285714 12.1 12 1 autoimmune response 5.3543453947061e-05 0.00096165589670263 1.30649348544321 0.709677419354839 12.1 12 1 decreased thymus weight 5.3543453947061e-05 0.00096165589670263 1.30649348544321 0.709677419354839 12.1 12 1 preaxial polydactyly 5.3543453947061e-05 0.00096165589670263 1.30649348544321 0.709677419354839 12.1 12 1 abnormal lymph node morphology 5.2838423040905e-07 1.63274009086026e-05 1.30401906596321 0.708333333333333 12.1 12 1 thymus atrophy 5.2838423040905e-07 1.63274009086026e-05 1.30401906596321 0.708333333333333 12.1 12 1 abnormal tumor morphology 0.000404872715615304 0.0055488753724136 1.30401906596321 0.708333333333333 12.1 12 1 abnormal cell differentiation 3.82935109462317e-06 9.47812024664191e-05 1.30214816342954 0.707317073170732 12.1 12 1 increased lung adenocarcinoma incidence 2.8096764076228e-07 9.18582129783949e-06 1.29950688926437 0.705882352941177 12.1 12 1 abnormal spleen red pulp morphology 2.81000151582766e-05 0.000563699900856556 1.29950688926437 0.705882352941177 12.1 12 1 abnormal direction of heart looping 2.81000151582766e-05 0.000563699900856556 1.29950688926437 0.705882352941177 12.1 12 1 pancytopenia 0.0031777603827045 0.0302861262527871 1.29950688926437 0.705882352941177 12.1 12 1 abnormal CD4-positive, alpha-beta T cell physiology 1.57938262989437e-09 8.54068324317878e-08 1.29645640360882 0.704225352112676 12.1 12 1 abnormal eye muscle morphology 0.000209988851479378 0.00321444472649202 1.29549606553208 0.703703703703704 12.1 12 1 decreased lymphocyte cell number 5.99362360028435e-16 7.89752541352303e-14 1.29443069047818 0.703125 12.1 12 1 decreased cell proliferation 2.40054500126458e-22 5.97135569064564e-20 1.29365325462805 0.702702702702703 12.1 12 1 abnormal respiratory electron transport chain 1.47687180975968e-05 0.000325107843077628 1.29365325462805 0.702702702702703 12.1 12 1 increased mammary adenocarcinoma incidence 0.00161508404535727 0.0174295946326517 1.28867766518717 0.7 12.1 12 1 abnormal physiological neovascularization 0.00161508404535727 0.0174295946326517 1.28867766518717 0.7 12.1 12 1 retarded hair growth 0.0268617590263543 0.152033277765771 1.28867766518717 0.7 12.1 12 1 enlarged testis 0.0268617590263543 0.152033277765771 1.28867766518717 0.7 12.1 12 1 absent trophoblast giant cells 0.0268617590263543 0.152033277765771 1.28867766518717 0.7 12.1 12 1 abnormal immune cell physiology 0.0268617590263543 0.152033277765771 1.28867766518717 0.7 12.1 12 1 acrania 0.0268617590263543 0.152033277765771 1.28867766518717 0.7 12.1 12 1 bifid ureter 0.0268617590263543 0.152033277765771 1.28867766518717 0.7 12.1 12 1 absent CD4-positive, alpha beta T cells 0.0268617590263543 0.152033277765771 1.28867766518717 0.7 12.1 12 1 osteosclerosis 0.0268617590263543 0.152033277765771 1.28867766518717 0.7 12.1 12 1 increased platelet aggregation 0.0268617590263543 0.152033277765771 1.28867766518717 0.7 12.1 12 1 increased T-helper 17 cell number 0.0268617590263543 0.152033277765771 1.28867766518717 0.7 12.1 12 1 decreased macrophage cytokine production 0.0268617590263543 0.152033277765771 1.28867766518717 0.7 12.1 12 1 pale yolk sac 1.29198218903078e-10 8.4573834084581e-09 1.28645963134003 0.698795180722892 12.1 12 1 seminiferous tubule degeneration 1.69910047071546e-09 8.89792088611519e-08 1.286155791087 0.698630136986301 12.1 12 1 enlarged spleen 4.25353517145965e-33 2.35125971977908e-30 1.28484231499316 0.697916666666667 12.1 12 1 embryonic lethality, complete penetrance 4.14575082210056e-36 2.94644433427861e-33 1.2811752873782 0.695924764890282 12.1 12 1 abnormal regulatory T cell physiology 0.000826798905711457 0.0101064485403305 1.28067345608663 0.695652173913043 12.1 12 1 spleen hypoplasia 8.11587172910996e-13 7.21008247362894e-11 1.27991115045801 0.695238095238095 12.1 12 1 abnormal pharyngeal arch morphology 2.98119204011288e-05 0.000588562806015154 1.27845006466981 0.694444444444444 12.1 12 1 increased T cell number 7.36378590962352e-11 5.01847053429822e-09 1.27612561000678 0.693181818181818 12.1 12 1 liver hypoplasia 6.03044387471814e-07 1.82935721199529e-05 1.27451637216314 0.692307692307692 12.1 12 1 abnormal leukocyte migration 6.03044387471814e-07 1.82935721199529e-05 1.27451637216314 0.692307692307692 12.1 12 1 increased autoantibody level 1.5622846681737e-05 0.000339404638609788 1.27451637216314 0.692307692307692 12.1 12 1 failure of heart looping 1.5622846681737e-05 0.000339404638609788 1.27451637216314 0.692307692307692 12.1 12 1 abnormal leukocyte cell number 0.000425663077023907 0.00578599401145885 1.27451637216314 0.692307692307692 12.1 12 1 abnormal coping response 0.0130831674706269 0.0935183306988059 1.27451637216314 0.692307692307692 12.1 12 1 axonal dystrophy 0.0130831674706269 0.0935183306988059 1.27451637216314 0.692307692307692 12.1 12 1 orthokeratosis 0.0130831674706269 0.0935183306988059 1.27451637216314 0.692307692307692 12.1 12 1 abnormal embryonic neuroepithelium morphology 1.68894273050042e-07 6.0449568951364e-06 1.26963316767209 0.689655172413793 12.1 12 1 decreased T cell number 2.70278280780556e-18 4.48211482294422e-16 1.26923887165728 0.68944099378882 12.1 12 1 abnormal NK cell physiology 8.94798277898317e-08 3.34708378386777e-06 1.26755180182345 0.688524590163934 12.1 12 1 abnormal embryonic hematopoiesis 0.000114288396273035 0.00186421236543722 1.26566556402311 0.6875 12.1 12 1 large intestinal inflammation 0.00649728729730568 0.0529901709903209 1.26566556402311 0.6875 12.1 12 1 abnormal neural tube closure 5.41558018947759e-10 3.20744183841083e-08 1.26427929286865 0.686746987951807 12.1 12 1 holoprosencephaly 5.95187840589108e-05 0.00105002110174852 1.26237812099968 0.685714285714286 12.1 12 1 abnormal hippocampus pyramidal cell morphology 5.95187840589108e-05 0.00105002110174852 1.26237812099968 0.685714285714286 12.1 12 1 increased hepatocellular carcinoma incidence 3.33886331322241e-07 1.07862629761568e-05 1.25960974792731 0.684210526315789 12.1 12 1 abnormal blastocyst morphology 0.00326955287988535 0.0304836517009372 1.25960974792731 0.684210526315789 12.1 12 1 Leydig cell hypoplasia 0.00326955287988535 0.0304836517009372 1.25960974792731 0.684210526315789 12.1 12 1 embryonic lethality between implantation and somite formation, incomplete penetrance 0.00326955287988535 0.0304836517009372 1.25960974792731 0.684210526315789 12.1 12 1 embryonic lethality during organogenesis, complete penetrance 2.50187388754578e-58 4.14894086351341e-55 1.25909067797624 0.683928571428571 12.1 12 1 anemia 1.27937063487008e-22 3.53603828248815e-20 1.256395286303 0.682464454976303 12.1 12 1 abnormal myelopoiesis 8.52979016574686e-06 0.000205998573177624 1.25520551803945 0.681818181818182 12.1 12 1 abnormal abdominal fat pad morphology 0.00166114518722716 0.0174350154144623 1.25520551803945 0.681818181818182 12.1 12 1 abnormal germ layer development 0.00166114518722716 0.0174350154144623 1.25520551803945 0.681818181818182 12.1 12 1 abnormal sperm midpiece morphology 0.00166114518722716 0.0174350154144623 1.25520551803945 0.681818181818182 12.1 12 1 abnormal cerebral cortex pyramidal cell morphology 0.00166114518722716 0.0174350154144623 1.25520551803945 0.681818181818182 12.1 12 1 increased mammary gland tumor incidence 0.00166114518722716 0.0174350154144623 1.25520551803945 0.681818181818182 12.1 12 1 increased bone volume 0.00166114518722716 0.0174350154144623 1.25520551803945 0.681818181818182 12.1 12 1 impaired humoral immune response 0.00166114518722716 0.0174350154144623 1.25520551803945 0.681818181818182 12.1 12 1 increased pre-B cell number 0.00085013553126987 0.0102721778784852 1.25185830332468 0.68 12.1 12 1 decreased B cell number 9.12859162334885e-22 2.16260682505526e-19 1.25114336425939 0.679611650485437 12.1 12 1 abnormal mesoderm development 1.24196029673985e-06 3.47120925633749e-05 1.25046889344308 0.679245283018868 12.1 12 1 increased neuron apoptosis 2.08201493997529e-09 1.06783755942032e-07 1.2500400632327 0.679012345679012 12.1 12 1 lethality throughout fetal growth and development, complete penetrance 4.08328408435209e-20 8.27755457611139e-18 1.24992044217402 0.678947368421053 12.1 12 1 abnormal spleen morphology 1.8252091060281e-18 3.13117769051373e-16 1.24847261487755 0.67816091954023 12.1 12 1 increased lung adenoma incidence 0.000226263951451612 0.00337850338676622 1.24710741792307 0.67741935483871 12.1 12 1 abnormal embryo development 1.28074343852046e-14 1.41593302369762e-12 1.24536076887836 0.676470588235294 12.1 12 1 enlarged liver sinusoidal spaces 0.000117442361025242 0.00189086001974297 1.24536076887836 0.676470588235294 12.1 12 1 decreased regulatory T cell number 0.000117442361025242 0.00189086001974297 1.24536076887836 0.676470588235294 12.1 12 1 increased susceptibility to viral infection induced morbidity/mortality 0.000117442361025242 0.00189086001974297 1.24536076887836 0.676470588235294 12.1 12 1 pallor 3.6625813433356e-18 5.69416943221706e-16 1.24133848564968 0.674285714285714 12.1 12 1 abnormal cell death 8.76056510036018e-06 0.000209537554684096 1.24065241058392 0.673913043478261 12.1 12 1 abnormal allantois morphology 8.76056510036018e-06 0.000209537554684096 1.24065241058392 0.673913043478261 12.1 12 1 kinked neural tube 2.42072956122677e-06 6.17596388056573e-05 1.23911313960305 0.673076923076923 12.1 12 1 abnormal rostral-caudal axis patterning 1.27518959772223e-06 3.52448236037115e-05 1.23846944446559 0.672727272727273 12.1 12 1 lethality throughout fetal growth and development, incomplete penetrance 3.87773883898661e-18 5.84598506786617e-16 1.23416855404996 0.670391061452514 12.1 12 1 thrombocytopenia 7.44219198420391e-15 8.41475116395783e-13 1.23154417264193 0.668965517241379 12.1 12 1 abnormal cytokine secretion 1.13042472606807e-15 1.44201615697145e-13 1.23129684150537 0.668831168831169 12.1 12 1 decreased erythrocyte cell number 6.03228071786684e-16 7.89752541352303e-14 1.23122069922341 0.668789808917197 12.1 12 1 absent mesoderm 6.84571821735761e-07 2.02897732477763e-05 1.22731206208302 0.666666666666667 12.1 12 1 incomplete embryo turning 1.29748089378405e-06 3.54668541020639e-05 1.22731206208302 0.666666666666667 12.1 12 1 increased cardiomyocyte apoptosis 0.000228855405294516 0.00337850338676622 1.22731206208302 0.666666666666667 12.1 12 1 increased metastatic potential 0.0004419281962379 0.00595824600618849 1.22731206208302 0.666666666666667 12.1 12 1 liver hemorrhage 0.0004419281962379 0.00595824600618849 1.22731206208302 0.666666666666667 12.1 12 1 abnormal cellular extravasation 0.00167065128590376 0.0174978739944657 1.22731206208302 0.666666666666667 12.1 12 1 left pulmonary isomerism 0.00327814143919626 0.0304836517009372 1.22731206208302 0.666666666666667 12.1 12 1 abnormal erythrocyte physiology 0.00327814143919626 0.0304836517009372 1.22731206208302 0.666666666666667 12.1 12 1 increased muscle cell glucose uptake 0.00327814143919626 0.0304836517009372 1.22731206208302 0.666666666666667 12.1 12 1 decreased hepatocyte number 0.0129832466931194 0.0932919302552181 1.22731206208302 0.666666666666667 12.1 12 1 increased papilloma incidence 0.0264047680118708 0.151340692233937 1.22731206208302 0.666666666666667 12.1 12 1 small intestinal inflammation 0.0264047680118708 0.151340692233937 1.22731206208302 0.666666666666667 12.1 12 1 increased hepatocyte proliferation 0.0264047680118708 0.151340692233937 1.22731206208302 0.666666666666667 12.1 12 1 pale placenta 0.0264047680118708 0.151340692233937 1.22731206208302 0.666666666666667 12.1 12 1 abnormal thymus corticomedullary boundary morphology 0.0264047680118708 0.151340692233937 1.22731206208302 0.666666666666667 12.1 12 1 decreased mammary gland epithelial cell proliferation 0.0264047680118708 0.151340692233937 1.22731206208302 0.666666666666667 12.1 12 1 persistent right dorsal aorta 0.0264047680118708 0.151340692233937 1.22731206208302 0.666666666666667 12.1 12 1 abnormal pulmonary valve cusp morphology 0.0264047680118708 0.151340692233937 1.22731206208302 0.666666666666667 12.1 12 1 embryonic lethality between implantation and placentation, incomplete penetrance 0.0264047680118708 0.151340692233937 1.22731206208302 0.666666666666667 12.1 12 1 abnormal colon goblet cell morphology 0.0264047680118708 0.151340692233937 1.22731206208302 0.666666666666667 12.1 12 1 small placenta 1.69639045236348e-05 0.000362335893856077 1.22731206208302 0.666666666666667 12.1 12 1 abnormal leukocyte adhesion 6.19909324228749e-05 0.00108593270705564 1.22731206208302 0.666666666666667 12.1 12 1 increased hepatocyte apoptosis 6.19909324228749e-05 0.00108593270705564 1.22731206208302 0.666666666666667 12.1 12 1 abnormal neutrophil morphology 0.00648697506576046 0.0529901709903209 1.22731206208302 0.666666666666667 12.1 12 1 distorted hair follicle pattern 0.0550269524047353 0.252164289222625 1.22731206208302 0.666666666666667 12.1 12 1 abnormal germ cell morphology 0.0550269524047353 0.252164289222625 1.22731206208302 0.666666666666667 12.1 12 1 abnormal vomeronasal organ morphology 0.0550269524047353 0.252164289222625 1.22731206208302 0.666666666666667 12.1 12 1 abnormal thymus lobule morphology 0.0550269524047353 0.252164289222625 1.22731206208302 0.666666666666667 12.1 12 1 abnormal artery development 0.0550269524047353 0.252164289222625 1.22731206208302 0.666666666666667 12.1 12 1 priapism 0.0550269524047353 0.252164289222625 1.22731206208302 0.666666666666667 12.1 12 1 premature neuronal precursor differentiation 0.0550269524047353 0.252164289222625 1.22731206208302 0.666666666666667 12.1 12 1 decreased fear-related response 0.0550269524047353 0.252164289222625 1.22731206208302 0.666666666666667 12.1 12 1 abnormal thymus physiology 0.0550269524047353 0.252164289222625 1.22731206208302 0.666666666666667 12.1 12 1 decreased cellular sensitivity to ionizing radiation 0.0550269524047353 0.252164289222625 1.22731206208302 0.666666666666667 12.1 12 1 short frontal bone 0.0550269524047353 0.252164289222625 1.22731206208302 0.666666666666667 12.1 12 1 decreased cochlear hair cell number 0.0550269524047353 0.252164289222625 1.22731206208302 0.666666666666667 12.1 12 1 positive geotaxis 0.0550269524047353 0.252164289222625 1.22731206208302 0.666666666666667 12.1 12 1 abnormal liver vasculature morphology 0.0550269524047353 0.252164289222625 1.22731206208302 0.666666666666667 12.1 12 1 axonal spheroids 0.0550269524047353 0.252164289222625 1.22731206208302 0.666666666666667 12.1 12 1 abnormal ventricle myocardium morphology 0.0550269524047353 0.252164289222625 1.22731206208302 0.666666666666667 12.1 12 1 abnormal pulmonary alveolar system morphology 0.0550269524047353 0.252164289222625 1.22731206208302 0.666666666666667 12.1 12 1 increased core body temperature 0.0550269524047353 0.252164289222625 1.22731206208302 0.666666666666667 12.1 12 1 trigeminal neuroma 0.0550269524047353 0.252164289222625 1.22731206208302 0.666666666666667 12.1 12 1 increased bone mineralization 0.0550269524047353 0.252164289222625 1.22731206208302 0.666666666666667 12.1 12 1 increased endoplasmic reticulum stress 0.0550269524047353 0.252164289222625 1.22731206208302 0.666666666666667 12.1 12 1 decreased leukocyte cell number 9.55658976189731e-14 9.50880681308782e-12 1.22283282098053 0.664233576642336 12.1 12 1 decreased rib number 2.2824708967194e-09 1.15769016168999e-07 1.22041705049828 0.662921348314607 12.1 12 1 increased monocyte cell number 3.466540177227e-10 2.19664000901818e-08 1.21503894146219 0.66 12.1 12 1 decreased IgM level 6.51522066807651e-10 3.7689793981024e-08 1.21465936041206 0.65979381443299 12.1 12 1 increased grip strength 2.30374524637807e-09 1.15769016168999e-07 1.21382511634584 0.659340659340659 12.1 12 1 muscular atrophy 3.25180200553738e-05 0.000636917912501909 1.2133653341048 0.659090909090909 12.1 12 1 increased bone marrow cell number 0.000118984713542534 0.00190337282917719 1.21116321916087 0.657894736842105 12.1 12 1 decreased hair follicle number 0.000118984713542534 0.00190337282917719 1.21116321916087 0.657894736842105 12.1 12 1 decreased IgG level 5.2703748159128e-11 3.6554138862073e-09 1.21072676394676 0.657657657657658 12.1 12 1 abnormal midbrain development 0.000228462550210711 0.00337850338676622 1.20977903262469 0.657142857142857 12.1 12 1 abnormal embryonic epiblast morphology 0.000228462550210711 0.00337850338676622 1.20977903262469 0.657142857142857 12.1 12 1 increased red blood cell distribution width 0.000228462550210711 0.00337850338676622 1.20977903262469 0.657142857142857 12.1 12 1 abnormal extraembryonic tissue morphology 3.48813187361682e-10 2.19664000901818e-08 1.20926335528768 0.656862745098039 12.1 12 1 decreased caudal vertebrae number 6.93553449708202e-07 2.04167361674456e-05 1.20813531111297 0.65625 12.1 12 1 increased double-positive T cell number 0.00085068086149465 0.0102721778784852 1.20615150928848 0.655172413793103 12.1 12 1 blood in lymph vessels 0.00085068086149465 0.0102721778784852 1.20615150928848 0.655172413793103 12.1 12 1 abnormal embryo size 5.29024723230002e-11 3.6554138862073e-09 1.20558972470102 0.654867256637168 12.1 12 1 abnormal T-helper 2 physiology 4.71066138071795e-06 0.000115446011670304 1.20499729731787 0.654545454545455 12.1 12 1 distended pericardium 8.94095827092392e-06 0.000212829030611706 1.20370990704296 0.653846153846154 12.1 12 1 increased susceptibility to otitis media 0.00165191683373448 0.0174350154144623 1.20370990704296 0.653846153846154 12.1 12 1 heart inflammation 0.00165191683373448 0.0174350154144623 1.20370990704296 0.653846153846154 12.1 12 1 increased leukemia incidence 0.00165191683373448 0.0174350154144623 1.20370990704296 0.653846153846154 12.1 12 1 failure of embryo implantation 0.00322554446506909 0.0304498742195801 1.20063136508121 0.652173913043478 12.1 12 1 dilated heart 0.00322554446506909 0.0304498742195801 1.20063136508121 0.652173913043478 12.1 12 1 abnormal hematopoietic stem cell physiology 0.00322554446506909 0.0304498742195801 1.20063136508121 0.652173913043478 12.1 12 1 decreased effector memory CD8-positive, alpha-beta T cell number 0.00322554446506909 0.0304498742195801 1.20063136508121 0.652173913043478 12.1 12 1 abnormal vertebral artery topology 0.00322554446506909 0.0304498742195801 1.20063136508121 0.652173913043478 12.1 12 1 anophthalmia 8.17358464857812e-09 3.69668942060692e-07 1.19973201574407 0.651685393258427 12.1 12 1 gliosis 1.30622313400643e-06 3.55107108835083e-05 1.19809034631914 0.650793650793651 12.1 12 1 abnormal vascular regression 0.00634213785829466 0.0519804544398945 1.19662926053094 0.65 12.1 12 1 small gonad 0.00634213785829466 0.0519804544398945 1.19662926053094 0.65 12.1 12 1 dilated vasculature 0.00634213785829466 0.0519804544398945 1.19662926053094 0.65 12.1 12 1 increased B cell number 5.27381114649346e-11 3.6554138862073e-09 1.19584252202961 0.64957264957265 12.1 12 1 prenatal lethality, complete penetrance 8.41243695155561e-24 2.79012492226595e-21 1.19199372936121 0.647482014388489 12.1 12 1 pericardial edema 6.85162192085714e-07 2.02897732477763e-05 1.19121464849234 0.647058823529412 12.1 12 1 increased brain size 0.0125830866407412 0.0909896163338479 1.19121464849234 0.647058823529412 12.1 12 1 increased hepatoma incidence 0.0125830866407412 0.0909896163338479 1.19121464849234 0.647058823529412 12.1 12 1 increased spleen weight 1.83710026898026e-10 1.18695764132166e-08 1.18929797166452 0.646017699115044 12.1 12 1 small heart 3.19178612369313e-05 0.000627633832623452 1.18895856014292 0.645833333333333 12.1 12 1 osteopetrosis 0.00083404500494024 0.0101700340675924 1.18772135040292 0.645161290322581 12.1 12 1 oxidative stress 1.51011931592611e-08 6.64853415640036e-07 1.18640166001359 0.644444444444444 12.1 12 1 abnormal brainstem morphology 0.00161199920647457 0.0174295946326517 1.1834794884372 0.642857142857143 12.1 12 1 abnormal antigen presentation 0.0252713457629959 0.150749334737296 1.1834794884372 0.642857142857143 12.1 12 1 failure of zygotic cell division 0.0252713457629959 0.150749334737296 1.1834794884372 0.642857142857143 12.1 12 1 abnormal vascular endothelial cell migration 0.0252713457629959 0.150749334737296 1.1834794884372 0.642857142857143 12.1 12 1 decreased compact bone area 0.0252713457629959 0.150749334737296 1.1834794884372 0.642857142857143 12.1 12 1 internal hemorrhage 1.27253400508813e-06 3.52448236037115e-05 1.18151683588589 0.641791044776119 12.1 12 1 increased sacral vertebrae number 2.39837344079892e-06 6.15046797318279e-05 1.1793701846579 0.640625 12.1 12 1 mandible hypoplasia 0.00312934596080845 0.0299394156827347 1.1782195795997 0.64 12.1 12 1 spontaneous skin ulceration 0.00312934596080845 0.0299394156827347 1.1782195795997 0.64 12.1 12 1 abnormal egg cylinder morphology 0.00312934596080845 0.0299394156827347 1.1782195795997 0.64 12.1 12 1 abnormal hepatocyte morphology 6.26022221395393e-10 3.66407123699068e-08 1.17755616767425 0.63963963963964 12.1 12 1 abnormal platelet physiology 1.61185283415017e-05 0.000347141465363511 1.17152515017015 0.636363636363636 12.1 12 1 decreased circulating total protein level 1.61185283415017e-05 0.000347141465363511 1.17152515017015 0.636363636363636 12.1 12 1 abnormal mesenteric lymph node morphology 0.00610788488014218 0.0509844417427976 1.17152515017015 0.636363636363636 12.1 12 1 premature suture closure 0.0516414652664745 0.249918569747773 1.17152515017015 0.636363636363636 12.1 12 1 impaired myelopoiesis 0.0516414652664745 0.249918569747773 1.17152515017015 0.636363636363636 12.1 12 1 failure of somite differentiation 0.0516414652664745 0.249918569747773 1.17152515017015 0.636363636363636 12.1 12 1 increased glycogen level 0.0516414652664745 0.249918569747773 1.17152515017015 0.636363636363636 12.1 12 1 abnormal palate development 0.0516414652664745 0.249918569747773 1.17152515017015 0.636363636363636 12.1 12 1 aorta dilation 0.0516414652664745 0.249918569747773 1.17152515017015 0.636363636363636 12.1 12 1 abnormal extraembryonic ectoderm morphology 0.0516414652664745 0.249918569747773 1.17152515017015 0.636363636363636 12.1 12 1 abnormal vascular development 2.34515122154977e-06 6.07662881625527e-05 1.17152515017015 0.636363636363636 12.1 12 1 myeloid hyperplasia 0.000809600571914057 0.00996971001305057 1.17152515017015 0.636363636363636 12.1 12 1 abnormal spermatogenesis 3.88214170045745e-15 4.5984892761371e-13 1.17061558095418 0.635869565217391 12.1 12 1 Leydig cell hyperplasia 0.000214355448750334 0.00326121821875508 1.1674431810058 0.634146341463415 12.1 12 1 arrested B cell differentiation 0.000214355448750334 0.00326121821875508 1.1674431810058 0.634146341463415 12.1 12 1 gastrointestinal hemorrhage 0.00155670819239267 0.0169096577667108 1.16594645897887 0.633333333333333 12.1 12 1 salivary gland inflammation 0.00155670819239267 0.0169096577667108 1.16594645897887 0.633333333333333 12.1 12 1 abnormal spleen marginal zone morphology 0.00155670819239267 0.0169096577667108 1.16594645897887 0.633333333333333 12.1 12 1 abnormal optic cup morphology 0.00155670819239267 0.0169096577667108 1.16594645897887 0.633333333333333 12.1 12 1 abnormal brain vasculature morphology 0.00155670819239267 0.0169096577667108 1.16594645897887 0.633333333333333 12.1 12 1 decreased mean corpuscular hemoglobin 2.28281352345226e-06 5.94607187391361e-05 1.16414158829933 0.632352941176471 12.1 12 1 small superior vagus ganglion 0.012002555955832 0.0872992922226083 1.16271669039444 0.631578947368421 12.1 12 1 abnormal nasal septum morphology 0.012002555955832 0.0872992922226083 1.16271669039444 0.631578947368421 12.1 12 1 increased susceptibility to ischemic brain injury 0.012002555955832 0.0872992922226083 1.16271669039444 0.631578947368421 12.1 12 1 absent amnion 0.012002555955832 0.0872992922226083 1.16271669039444 0.631578947368421 12.1 12 1 astrocytosis 1.18108323965819e-06 3.35765092417114e-05 1.16006208607847 0.63013698630137 12.1 12 1 neurodegeneration 2.95090997732636e-05 0.000587231085487945 1.15912805863396 0.62962962962963 12.1 12 1 abnormal fetal cardiomyocyte proliferation 0.00300325585329105 0.0289615252831477 1.15912805863396 0.62962962962963 12.1 12 1 decreased circulating fructosamine level 0.00300325585329105 0.0289615252831477 1.15912805863396 0.62962962962963 12.1 12 1 abnormal humoral immune response 7.06934174075256e-09 3.22660322571046e-07 1.1571799442497 0.628571428571429 12.1 12 1 abnormal liver development 0.000779443596509037 0.00969432973158115 1.1571799442497 0.628571428571429 12.1 12 1 increased circulating serum albumin level 0.000779443596509037 0.00969432973158115 1.1571799442497 0.628571428571429 12.1 12 1 decreased glycogen level 0.000779443596509037 0.00969432973158115 1.1571799442497 0.628571428571429 12.1 12 1 failure of chorioallantoic fusion 5.56528017857199e-05 0.000992375228974755 1.15511723490167 0.627450980392157 12.1 12 1 abnormal vitelline vasculature morphology 1.91745481369833e-09 9.93681010223874e-08 1.15260611047797 0.626086956521739 12.1 12 1 liver inflammation 9.98528556006686e-10 5.64509041606053e-08 1.15060505820283 0.625 12.1 12 1 abnormal spongiotrophoblast layer morphology 0.0014907275700349 0.0166286315267346 1.15060505820283 0.625 12.1 12 1 pancreatic islet hyperplasia 0.0014907275700349 0.0166286315267346 1.15060505820283 0.625 12.1 12 1 hemolytic anemia 0.00581703309701133 0.0490004528294588 1.15060505820283 0.625 12.1 12 1 small lymph nodes 0.00581703309701133 0.0490004528294588 1.15060505820283 0.625 12.1 12 1 abnormal bone marrow cell number 0.0237931790194756 0.14365420585181 1.15060505820283 0.625 12.1 12 1 decreased mast cell number 0.0237931790194756 0.14365420585181 1.15060505820283 0.625 12.1 12 1 mixed cellular infiltration to dermis 0.0237931790194756 0.14365420585181 1.15060505820283 0.625 12.1 12 1 small epididymis 0.0237931790194756 0.14365420585181 1.15060505820283 0.625 12.1 12 1 impaired somite development 0.0237931790194756 0.14365420585181 1.15060505820283 0.625 12.1 12 1 abnormal pulmonary alveolus wall morphology 0.0237931790194756 0.14365420585181 1.15060505820283 0.625 12.1 12 1 embryonic lethality between somite formation and embryo turning, incomplete penetrance 0.0237931790194756 0.14365420585181 1.15060505820283 0.625 12.1 12 1 decreased midbrain size 0.0237931790194756 0.14365420585181 1.15060505820283 0.625 12.1 12 1 abnormal exoccipital bone morphology 0.108379417408521 0.417444052508226 1.15060505820283 0.625 12.1 12 1 abnormal bone marrow development 0.108379417408521 0.417444052508226 1.15060505820283 0.625 12.1 12 1 absent pre-B cells 0.108379417408521 0.417444052508226 1.15060505820283 0.625 12.1 12 1 schistocytosis 0.108379417408521 0.417444052508226 1.15060505820283 0.625 12.1 12 1 abnormal cecum morphology 0.108379417408521 0.417444052508226 1.15060505820283 0.625 12.1 12 1 abnormal vagus ganglion morphology 0.108379417408521 0.417444052508226 1.15060505820283 0.625 12.1 12 1 dry eyes 0.108379417408521 0.417444052508226 1.15060505820283 0.625 12.1 12 1 joint swelling 0.108379417408521 0.417444052508226 1.15060505820283 0.625 12.1 12 1 vascular smooth muscle hypertrophy 0.108379417408521 0.417444052508226 1.15060505820283 0.625 12.1 12 1 decreased aerobic running capacity 0.108379417408521 0.417444052508226 1.15060505820283 0.625 12.1 12 1 abnormal cellular cholesterol metabolism 0.108379417408521 0.417444052508226 1.15060505820283 0.625 12.1 12 1 abnormal neuron apoptosis 0.108379417408521 0.417444052508226 1.15060505820283 0.625 12.1 12 1 decreased susceptibility to age related obesity 0.108379417408521 0.417444052508226 1.15060505820283 0.625 12.1 12 1 liver cysts 0.108379417408521 0.417444052508226 1.15060505820283 0.625 12.1 12 1 abnormal eyelid aperture 0.108379417408521 0.417444052508226 1.15060505820283 0.625 12.1 12 1 absent cochlear microphonics 0.108379417408521 0.417444052508226 1.15060505820283 0.625 12.1 12 1 abnormal optic choroid morphology 0.108379417408521 0.417444052508226 1.15060505820283 0.625 12.1 12 1 abnormal somite size 0.108379417408521 0.417444052508226 1.15060505820283 0.625 12.1 12 1 abnormal vertebral body development 0.108379417408521 0.417444052508226 1.15060505820283 0.625 12.1 12 1 craniofacial phenotype 0.108379417408521 0.417444052508226 1.15060505820283 0.625 12.1 12 1 stomach epithelial hyperplasia 0.108379417408521 0.417444052508226 1.15060505820283 0.625 12.1 12 1 choroidal neovascularization 0.108379417408521 0.417444052508226 1.15060505820283 0.625 12.1 12 1 abnormal epidermal lamellar body morphology 0.108379417408521 0.417444052508226 1.15060505820283 0.625 12.1 12 1 enlarged inguinal lymph nodes 0.108379417408521 0.417444052508226 1.15060505820283 0.625 12.1 12 1 abnormal frontonasal prominence morphology 0.108379417408521 0.417444052508226 1.15060505820283 0.625 12.1 12 1 decreased hippocampus pyramidal cell number 0.108379417408521 0.417444052508226 1.15060505820283 0.625 12.1 12 1 decreased quadriceps weight 0.108379417408521 0.417444052508226 1.15060505820283 0.625 12.1 12 1 increased heart right ventricle size 0.108379417408521 0.417444052508226 1.15060505820283 0.625 12.1 12 1 abnormal bronchiole epithelium morphology 0.108379417408521 0.417444052508226 1.15060505820283 0.625 12.1 12 1 abnormal maxillary prominence morphology 0.108379417408521 0.417444052508226 1.15060505820283 0.625 12.1 12 1 increased aorta wall thickness 0.108379417408521 0.417444052508226 1.15060505820283 0.625 12.1 12 1 lethality during fetal growth through weaning, incomplete penetrance 0.108379417408521 0.417444052508226 1.15060505820283 0.625 12.1 12 1 decreased cranium length 0.108379417408521 0.417444052508226 1.15060505820283 0.625 12.1 12 1 abnormal heart echocardiography feature 0.108379417408521 0.417444052508226 1.15060505820283 0.625 12.1 12 1 prolonged PQ interval 0.108379417408521 0.417444052508226 1.15060505820283 0.625 12.1 12 1 increased circulating lactate level 0.108379417408521 0.417444052508226 1.15060505820283 0.625 12.1 12 1 increased testis apoptosis 0.108379417408521 0.417444052508226 1.15060505820283 0.625 12.1 12 1 embryo cyst 0.108379417408521 0.417444052508226 1.15060505820283 0.625 12.1 12 1 decreased basal metabolism 0.108379417408521 0.417444052508226 1.15060505820283 0.625 12.1 12 1 decreased vascular endothelial cell proliferation 0.108379417408521 0.417444052508226 1.15060505820283 0.625 12.1 12 1 increased lymphocyte cell number 3.99651135813708e-06 9.8428930726396e-05 1.1472699710776 0.623188405797101 12.1 12 1 decreased birth body size 3.44076606938788e-09 1.6459433841543e-07 1.14656784747229 0.62280701754386 12.1 12 1 small seminiferous tubules 2.05726144110904e-06 5.38677666816709e-05 1.14438557140173 0.621621621621622 12.1 12 1 abnormal branching of the mammary ductal tree 0.000745301347427445 0.0094108482321105 1.14438557140173 0.621621621621622 12.1 12 1 increased erythroid progenitor cell number 0.000745301347427445 0.0094108482321105 1.14438557140173 0.621621621621622 12.1 12 1 skin inflammation 0.000745301347427445 0.0094108482321105 1.14438557140173 0.621621621621622 12.1 12 1 thrombocytosis 2.73073716951109e-05 0.000552252740582019 1.14266985090488 0.620689655172414 12.1 12 1 decreased trophoblast giant cell number 0.00285779286189627 0.0281535039365028 1.14266985090488 0.620689655172414 12.1 12 1 testicular atrophy 0.000100604796324155 0.00166836287237558 1.14140021773721 0.62 12.1 12 1 decreased oocyte number 0.000100604796324155 0.00166836287237558 1.14140021773721 0.62 12.1 12 1 disheveled coat 0.000374733130813712 0.00514999261270225 1.13964691479138 0.619047619047619 12.1 12 1 abnormal salivary gland morphology 0.0113211320393295 0.0852082176938947 1.13964691479138 0.619047619047619 12.1 12 1 liver degeneration 0.0113211320393295 0.0852082176938947 1.13964691479138 0.619047619047619 12.1 12 1 increased keratinocyte proliferation 0.0113211320393295 0.0852082176938947 1.13964691479138 0.619047619047619 12.1 12 1 abnormal embryonic tissue morphology 3.67933927781305e-11 2.65285694306086e-09 1.13964691479138 0.619047619047619 12.1 12 1 abnormal head morphology 5.11890725675447e-05 0.000933190215493772 1.13805300302244 0.618181818181818 12.1 12 1 abnormal erythrocyte osmotic lysis 0.00549323256412682 0.0467959452166625 1.13290344192279 0.615384615384615 12.1 12 1 decreased bone resorption 0.00549323256412682 0.0467959452166625 1.13290344192279 0.615384615384615 12.1 12 1 abnormal nerve conduction 0.00549323256412682 0.0467959452166625 1.13290344192279 0.615384615384615 12.1 12 1 short premaxilla 0.047719328877861 0.236222548425232 1.13290344192279 0.615384615384615 12.1 12 1 absent common myeloid progenitor cells 0.047719328877861 0.236222548425232 1.13290344192279 0.615384615384615 12.1 12 1 abnormal mast cell morphology 0.047719328877861 0.236222548425232 1.13290344192279 0.615384615384615 12.1 12 1 excessive scratching 0.047719328877861 0.236222548425232 1.13290344192279 0.615384615384615 12.1 12 1 abnormal grip strength 0.047719328877861 0.236222548425232 1.13290344192279 0.615384615384615 12.1 12 1 abnormal exocrine pancreas morphology 0.047719328877861 0.236222548425232 1.13290344192279 0.615384615384615 12.1 12 1 increased circulating thyroxine level 0.047719328877861 0.236222548425232 1.13290344192279 0.615384615384615 12.1 12 1 empty decidua capsularis 0.047719328877861 0.236222548425232 1.13290344192279 0.615384615384615 12.1 12 1 decreased brain weight 4.87991505282546e-05 0.000899169532881728 1.13041900455015 0.614035087719298 12.1 12 1 increased neutrophil cell number 1.15265942018709e-10 7.6459741539077e-09 1.12997351922816 0.613793103448276 12.1 12 1 lethality, incomplete penetrance 0.000356176803737136 0.0049774707825625 1.12968496623551 0.613636363636364 12.1 12 1 pericardial effusion 2.48821735925546e-05 0.000509418986102712 1.12833528288278 0.612903225806452 12.1 12 1 abnormal small intestine morphology 9.11735840310982e-05 0.00153239385322538 1.12503605690943 0.611111111111111 12.1 12 1 decreased tumor growth/size 9.11735840310982e-05 0.00153239385322538 1.12503605690943 0.611111111111111 12.1 12 1 axon degeneration 9.11735840310982e-05 0.00153239385322538 1.12503605690943 0.611111111111111 12.1 12 1 abnormal bile duct morphology 0.0221626905442823 0.139965080134917 1.12503605690943 0.611111111111111 12.1 12 1 darkened coat color 0.0221626905442823 0.139965080134917 1.12503605690943 0.611111111111111 12.1 12 1 decreased lactate dehydrogenase level 0.0221626905442823 0.139965080134917 1.12503605690943 0.611111111111111 12.1 12 1 increased adipocyte glucose uptake 0.0221626905442823 0.139965080134917 1.12503605690943 0.611111111111111 12.1 12 1 increased inflammatory response 2.46035838676748e-07 8.27046146903257e-06 1.12395946738129 0.610526315789474 12.1 12 1 abnormal B cell morphology 0.0105915255258114 0.0806934754837855 1.1205892740758 0.608695652173913 12.1 12 1 decreased spleen weight 1.20778277824118e-05 0.000269449296939457 1.1205892740758 0.608695652173913 12.1 12 1 abnormal gastrulation 0.00017028038785873 0.00263088487452541 1.11901982131099 0.607843137254902 12.1 12 1 abnormal response to infection 3.17113491179102e-06 7.96787686169712e-05 1.11856289202503 0.607594936708861 12.1 12 1 increased bone resorption 0.00515337976200741 0.0452969334204715 1.11773062796846 0.607142857142857 12.1 12 1 increased mean corpuscular hemoglobin 2.22212768308917e-07 7.61937573240978e-06 1.11573823825729 0.606060606060606 12.1 12 1 increased osteoblast cell number 0.00253861525945162 0.0253606644895016 1.11573823825729 0.606060606060606 12.1 12 1 incomplete somite formation 0.00126191269353849 0.0145661616017494 1.114270161628 0.605263157894737 12.1 12 1 abnormal vasculogenesis 0.000631622429589777 0.00811969402379623 1.11314349816832 0.604651162790698 12.1 12 1 small spleen 7.93703498174423e-07 2.28247104243801e-05 1.11267302331702 0.604395604395604 12.1 12 1 dermatitis 8.15040313612997e-05 0.00139582147698628 1.11092902171308 0.603448275862069 12.1 12 1 abnormal spermiogenesis 8.15040313612997e-05 0.00139582147698628 1.11092902171308 0.603448275862069 12.1 12 1 decreased circulating alanine transaminase level 2.11537041717406e-05 0.000438498659393374 1.10999546791332 0.602941176470588 12.1 12 1 decreased hemoglobin content 1.07488775284145e-09 6.00850176447889e-08 1.10980346039422 0.602836879432624 12.1 12 1 abnormal craniofacial morphology 1.99264908035041e-07 6.88432581579396e-06 1.10815555120117 0.601941747572815 12.1 12 1 intracranial hemorrhage 7.67344774015882e-05 0.00132553480928091 1.10458085587472 0.6 12.1 12 1 muscular ventricular septal defect 7.67344774015882e-05 0.00132553480928091 1.10458085587472 0.6 12.1 12 1 ovary cysts 0.00237526801476068 0.0238726431786553 1.10458085587472 0.6 12.1 12 1 decreased circulating thyroxine level 0.00237526801476068 0.0238726431786553 1.10458085587472 0.6 12.1 12 1 abnormal microglial cell physiology 0.00480941986615164 0.0430339277591806 1.10458085587472 0.6 12.1 12 1 brain inflammation 0.0204931831021379 0.132004651132075 1.10458085587472 0.6 12.1 12 1 decreased myocardial infarction size 0.0204931831021379 0.132004651132075 1.10458085587472 0.6 12.1 12 1 abnormal sperm mitochondrial sheath morphology 0.0204931831021379 0.132004651132075 1.10458085587472 0.6 12.1 12 1 abnormal fontanelle morphology 0.0437034943678105 0.219843159231403 1.10458085587472 0.6 12.1 12 1 abnormal epidermis stratum spinosum morphology 0.0437034943678105 0.219843159231403 1.10458085587472 0.6 12.1 12 1 increased airway responsiveness 0.0437034943678105 0.219843159231403 1.10458085587472 0.6 12.1 12 1 arthritis 0.0437034943678105 0.219843159231403 1.10458085587472 0.6 12.1 12 1 liver vascular congestion 0.0437034943678105 0.219843159231403 1.10458085587472 0.6 12.1 12 1 abnormal microglial cell activation 0.0437034943678105 0.219843159231403 1.10458085587472 0.6 12.1 12 1 decreased brown adipose tissue mass 0.0437034943678105 0.219843159231403 1.10458085587472 0.6 12.1 12 1 abnormal prostate gland epithelium morphology 0.0972747424723064 0.394403149463385 1.10458085587472 0.6 12.1 12 1 rhinitis 0.0972747424723064 0.394403149463385 1.10458085587472 0.6 12.1 12 1 abnormal gland morphology 0.0972747424723064 0.394403149463385 1.10458085587472 0.6 12.1 12 1 abnormal airway responsiveness 0.0972747424723064 0.394403149463385 1.10458085587472 0.6 12.1 12 1 ketoaciduria 0.0972747424723064 0.394403149463385 1.10458085587472 0.6 12.1 12 1 abnormal neuron specification 0.0972747424723064 0.394403149463385 1.10458085587472 0.6 12.1 12 1 aneurysm 0.0972747424723064 0.394403149463385 1.10458085587472 0.6 12.1 12 1 abnormal submandibular gland morphology 0.0972747424723064 0.394403149463385 1.10458085587472 0.6 12.1 12 1 increased heart rate variability 0.0972747424723064 0.394403149463385 1.10458085587472 0.6 12.1 12 1 abnormal reproductive system development 0.0972747424723064 0.394403149463385 1.10458085587472 0.6 12.1 12 1 abnormal respiratory conducting tube morphology 0.0972747424723064 0.394403149463385 1.10458085587472 0.6 12.1 12 1 ascites 0.0972747424723064 0.394403149463385 1.10458085587472 0.6 12.1 12 1 tachypnea 0.0972747424723064 0.394403149463385 1.10458085587472 0.6 12.1 12 1 protruding tongue 0.0972747424723064 0.394403149463385 1.10458085587472 0.6 12.1 12 1 abnormal hippocampus neuron morphology 0.0972747424723064 0.394403149463385 1.10458085587472 0.6 12.1 12 1 increased circulating fructosamine level 0.0972747424723064 0.394403149463385 1.10458085587472 0.6 12.1 12 1 abnormal left subclavian artery morphology 0.0972747424723064 0.394403149463385 1.10458085587472 0.6 12.1 12 1 thin ventricle myocardium compact layer 0.0972747424723064 0.394403149463385 1.10458085587472 0.6 12.1 12 1 thick aortic valve cusps 0.0972747424723064 0.394403149463385 1.10458085587472 0.6 12.1 12 1 abnormal adaptive thermogenesis 0.0972747424723064 0.394403149463385 1.10458085587472 0.6 12.1 12 1 hydroencephaly 5.01536603484053e-08 1.96468078923871e-06 1.10458085587472 0.6 12.1 12 1 abnormal coat/hair pigmentation 9.16389268651148e-08 3.40226612801452e-06 1.10129341285128 0.598214285714286 12.1 12 1 absent vitelline blood vessels 0.000141821423071527 0.00223278980943305 1.09812131870586 0.596491228070175 12.1 12 1 decreased IgA level 0.000279996281625175 0.00397994714595785 1.0975002093627 0.596153846153846 12.1 12 1 abnormal placenta vasculature 0.000279996281625175 0.00397994714595785 1.0975002093627 0.596153846153846 12.1 12 1 decreased circulating serum albumin level 6.2905774300456e-07 1.88527847677572e-05 1.097142600953 0.595959595959596 12.1 12 1 neuron degeneration 0.000554951856302731 0.00724641859607897 1.09674694909546 0.595744680851064 12.1 12 1 abnormal T-helper 1 physiology 0.000554951856302731 0.00724641859607897 1.09674694909546 0.595744680851064 12.1 12 1 prenatal lethality, incomplete penetrance 3.56674289425143e-18 5.69416943221706e-16 1.09610271334059 0.595394736842105 12.1 12 1 skin edema 0.00110517314601434 0.0129370268268738 1.09581434114555 0.595238095238095 12.1 12 1 abnormal placenta labyrinth morphology 9.01552618589026e-06 0.000213582108451448 1.09525949844118 0.594936708860759 12.1 12 1 abnormal angiogenesis 1.7605119012109e-05 0.000372704115256351 1.09462967699296 0.594594594594595 12.1 12 1 increased granulocyte number 1.7605119012109e-05 0.000372704115256351 1.09462967699296 0.594594594594595 12.1 12 1 abnormal calcium ion homeostasis 0.00221408301414993 0.0223429269683486 1.09462967699296 0.594594594594595 12.1 12 1 microcephaly 3.44433803132575e-05 0.000666754151978428 1.093908577074 0.594202898550725 12.1 12 1 perimembraneous ventricular septal defect 3.44433803132575e-05 0.000666754151978428 1.093908577074 0.594202898550725 12.1 12 1 scoliosis 0.00446967485821731 0.0401383256672042 1.09307480529269 0.59375 12.1 12 1 increased fatty acid level 0.00446967485821731 0.0401383256672042 1.09307480529269 0.59375 12.1 12 1 increased leukocyte cell number 2.6653173311166e-09 1.29999546297109e-07 1.091884524198 0.593103448275862 12.1 12 1 abnormal cell adhesion 0.000261751559084071 0.00379654229283747 1.09094405518491 0.592592592592593 12.1 12 1 abnormal atrioventricular cushion morphology 0.00911501687079702 0.0714386553960273 1.09094405518491 0.592592592592593 12.1 12 1 increased brain weight 0.00911501687079702 0.0714386553960273 1.09094405518491 0.592592592592593 12.1 12 1 abnormal craniofacial development 0.000517965386371825 0.00683455458033858 1.08955254491044 0.591836734693878 12.1 12 1 abnormal testis morphology 1.38704060045796e-07 5.00038187483939e-06 1.08857243767363 0.591304347826087 12.1 12 1 osteoporosis 0.00102948833359915 0.0120794916501315 1.08784478230086 0.590909090909091 12.1 12 1 intestinal inflammation 0.0188513779359335 0.123564697274399 1.08784478230086 0.590909090909091 12.1 12 1 abnormal chorion morphology 0.0188513779359335 0.123564697274399 1.08784478230086 0.590909090909091 12.1 12 1 cleft upper lip 0.0188513779359335 0.123564697274399 1.08784478230086 0.590909090909091 12.1 12 1 decreased circulating estradiol level 0.0188513779359335 0.123564697274399 1.08784478230086 0.590909090909091 12.1 12 1 abnormal occipital bone morphology 0.0188513779359335 0.123564697274399 1.08784478230086 0.590909090909091 12.1 12 1 decreased susceptibility to viral infection induced morbidity/mortality 0.0188513779359335 0.123564697274399 1.08784478230086 0.590909090909091 12.1 12 1 abnormal male meiosis 0.000124004092407233 0.00196471452142033 1.08647297299153 0.590163934426229 12.1 12 1 abnormal seminiferous tubule morphology 4.2496509002226e-09 1.97588908678574e-07 1.08440586307335 0.589041095890411 12.1 12 1 abnormal oocyte morphology 0.00413981796751149 0.0374465352515812 1.08292240772031 0.588235294117647 12.1 12 1 abnormal brown adipose tissue morphology 0.00413981796751149 0.0374465352515812 1.08292240772031 0.588235294117647 12.1 12 1 abnormal interatrial septum morphology 0.0398075967033822 0.214100317404677 1.08292240772031 0.588235294117647 12.1 12 1 hyperlipidemia 0.0398075967033822 0.214100317404677 1.08292240772031 0.588235294117647 12.1 12 1 abnormal dorsal-ventral axis patterning 0.0398075967033822 0.214100317404677 1.08292240772031 0.588235294117647 12.1 12 1 abnormal ductus venosus valve morphology 0.0398075967033822 0.214100317404677 1.08292240772031 0.588235294117647 12.1 12 1 abnormal cell cytoskeleton morphology 0.0398075967033822 0.214100317404677 1.08292240772031 0.588235294117647 12.1 12 1 hemorrhage 1.46638969392966e-13 1.43044877005883e-11 1.08107913553696 0.587234042553191 12.1 12 1 increased bone mineral content 4.55621630262798e-07 1.44376917869899e-05 1.08093539412816 0.587155963302752 12.1 12 1 small testis 1.24413461243915e-15 1.54739242422119e-13 1.08056822857309 0.58695652173913 12.1 12 1 abnormal immune system morphology 0.000956570599636328 0.0113038924778877 1.08056822857309 0.58695652173913 12.1 12 1 lordosis 0.00840546120383156 0.0665878495048758 1.07918819252128 0.586206896551724 12.1 12 1 thick ventricular wall 0.00190659155658312 0.0195170637736647 1.07763985938997 0.585365853658537 12.1 12 1 hemopericardium 0.00190659155658312 0.0195170637736647 1.07763985938997 0.585365853658537 12.1 12 1 azoospermia 1.69096205351071e-09 8.89792088611519e-08 1.07679265824265 0.584905660377358 12.1 12 1 atrioventricular septal defect 0.000448140235149044 0.00602566937801755 1.07679265824265 0.584905660377358 12.1 12 1 overriding aortic valve 0.000886872670246698 0.0106042155754176 1.07389805432264 0.583333333333333 12.1 12 1 ocular hypertelorism 0.0172758149261316 0.114902646066183 1.07389805432264 0.583333333333333 12.1 12 1 increased growth rate 0.0869728414229199 0.3632996524593 1.07389805432264 0.583333333333333 12.1 12 1 abnormal gastrocnemius morphology 0.0869728414229199 0.3632996524593 1.07389805432264 0.583333333333333 12.1 12 1 loss of dopaminergic neurons 0.0869728414229199 0.3632996524593 1.07389805432264 0.583333333333333 12.1 12 1 decreased circulating ketone body level 0.0869728414229199 0.3632996524593 1.07389805432264 0.583333333333333 12.1 12 1 abnormal defecation 0.0869728414229199 0.3632996524593 1.07389805432264 0.583333333333333 12.1 12 1 abnormal rostral-caudal body axis extension 0.0869728414229199 0.3632996524593 1.07389805432264 0.583333333333333 12.1 12 1 abnormal cochlear outer hair cell physiology 0.0869728414229199 0.3632996524593 1.07389805432264 0.583333333333333 12.1 12 1 hydrops fetalis 5.11333691668341e-05 0.000933190215493772 1.07389805432264 0.583333333333333 12.1 12 1 abnormal behavior 3.0656077346534e-15 3.71985328778065e-13 1.07279435642509 0.58273381294964 12.1 12 1 abnormal placenta morphology 2.43762989687361e-05 0.000501124327972984 1.07195610485732 0.582278481012658 12.1 12 1 ventricular septal defect 4.17571695202063e-08 1.67533805131473e-06 1.06938587762381 0.580882352941177 12.1 12 1 abnormal capillary morphology 0.00772887442655685 0.0617193423308512 1.06894921536263 0.580645161290323 12.1 12 1 decreased circulating alkaline phosphatase level 0.00082068171906171 0.0100563831338227 1.06776149401223 0.58 12.1 12 1 abnormal sternum morphology 9.27765367226097e-05 0.00154887003421135 1.06722788007219 0.579710144927536 12.1 12 1 abnormal dendritic cell physiology 1.28764843253825e-06 3.53925466954574e-05 1.06672917545533 0.579439252336449 12.1 12 1 kyphoscoliosis 0.0361328756034014 0.197106421191801 1.06582363286157 0.578947368421053 12.1 12 1 enlarged adrenal glands 0.0361328756034014 0.197106421191801 1.06582363286157 0.578947368421053 12.1 12 1 abnormal stationary movement 0.0361328756034014 0.197106421191801 1.06582363286157 0.578947368421053 12.1 12 1 decreased circulating magnesium level 0.0361328756034014 0.197106421191801 1.06582363286157 0.578947368421053 12.1 12 1 embryonic lethality during organogenesis, incomplete penetrance 1.9224022344634e-12 1.58428853389677e-10 1.06455981037201 0.578260869565217 12.1 12 1 trabecula carnea hypoplasia 0.00162683109378821 0.0174350154144623 1.06367045380528 0.577777777777778 12.1 12 1 abnormal ectoderm development 0.00162683109378821 0.0174350154144623 1.06367045380528 0.577777777777778 12.1 12 1 increased rib number 4.08798490172996e-05 0.000761712542550806 1.06209697680261 0.576923076923077 12.1 12 1 decreased circulating glycerol level 0.0157876518520278 0.105569311779352 1.06209697680261 0.576923076923077 12.1 12 1 abnormal Mullerian duct morphology 0.0157876518520278 0.105569311779352 1.06209697680261 0.576923076923077 12.1 12 1 decreased body length 2.3517141512468e-14 2.48931444733039e-12 1.06158014129079 0.576642335766423 12.1 12 1 enlarged pericardium 0.00709039859939935 0.0567251804349612 1.05995132634443 0.575757575757576 12.1 12 1 abnormal ovarian folliculogenesis 0.00709039859939935 0.0567251804349612 1.05995132634443 0.575757575757576 12.1 12 1 abnormal epidermis stratum basale morphology 0.00709039859939935 0.0567251804349612 1.05995132634443 0.575757575757576 12.1 12 1 abnormal QRS complex 0.00709039859939935 0.0567251804349612 1.05995132634443 0.575757575757576 12.1 12 1 abnormal pancreatic beta cell morphology 0.00324031312577596 0.0304736442357947 1.0585566535466 0.575 12.1 12 1 decreased bone trabecula number 0.00149875590313669 0.0166807843805482 1.0575774151992 0.574468085106383 12.1 12 1 increased circulating alkaline phosphatase level 6.30799623325586e-09 2.90576678337481e-07 1.05685205346038 0.574074074074074 12.1 12 1 increased cell proliferation 0.000699359755062706 0.00892131995240247 1.05685205346038 0.574074074074074 12.1 12 1 decreased platelet aggregation 0.000699359755062706 0.00892131995240247 1.05685205346038 0.574074074074074 12.1 12 1 kyphosis 2.4996826560317e-08 1.0720621735998e-06 1.0554883733914 0.573333333333333 12.1 12 1 abnormal immune system physiology 4.26460830547566e-07 1.36002732818855e-05 1.05410269848259 0.57258064516129 12.1 12 1 abnormal dermal layer morphology 0.00649255123784587 0.0529901709903209 1.05198176749973 0.571428571428571 12.1 12 1 abnormal eye pigmentation 0.0327225845192159 0.181084380403892 1.05198176749973 0.571428571428571 12.1 12 1 trunk curl 0.0327225845192159 0.181084380403892 1.05198176749973 0.571428571428571 12.1 12 1 decreased cochlear outer hair cell number 0.0327225845192159 0.181084380403892 1.05198176749973 0.571428571428571 12.1 12 1 increased acute inflammation 0.0327225845192159 0.181084380403892 1.05198176749973 0.571428571428571 12.1 12 1 decreased circulating creatinine level 0.00137874904874652 0.0157322855906284 1.05198176749973 0.571428571428571 12.1 12 1 rib bifurcation 0.0143971996825164 0.101388601060016 1.05198176749973 0.571428571428571 12.1 12 1 shortened head 0.0143971996825164 0.101388601060016 1.05198176749973 0.571428571428571 12.1 12 1 small superior cervical ganglion 0.0143971996825164 0.101388601060016 1.05198176749973 0.571428571428571 12.1 12 1 abnormal somite shape 0.0143971996825164 0.101388601060016 1.05198176749973 0.571428571428571 12.1 12 1 abnormal spleen germinal center morphology 0.0143971996825164 0.101388601060016 1.05198176749973 0.571428571428571 12.1 12 1 straub tail 0.0143971996825164 0.101388601060016 1.05198176749973 0.571428571428571 12.1 12 1 midline facial cleft 0.0776499730310143 0.329333858336996 1.05198176749973 0.571428571428571 12.1 12 1 abnormal ventral body wall morphology 0.0776499730310143 0.329333858336996 1.05198176749973 0.571428571428571 12.1 12 1 absent olfactory bulb 0.0776499730310143 0.329333858336996 1.05198176749973 0.571428571428571 12.1 12 1 split sternum 0.0776499730310143 0.329333858336996 1.05198176749973 0.571428571428571 12.1 12 1 increased B-1 B cell number 0.0776499730310143 0.329333858336996 1.05198176749973 0.571428571428571 12.1 12 1 decreased CNS synapse formation 0.0776499730310143 0.329333858336996 1.05198176749973 0.571428571428571 12.1 12 1 abnormal iris pigmentation 0.0776499730310143 0.329333858336996 1.05198176749973 0.571428571428571 12.1 12 1 abnormal viscerocranium morphology 0.0776499730310143 0.329333858336996 1.05198176749973 0.571428571428571 12.1 12 1 spina bifida occulta 0.0776499730310143 0.329333858336996 1.05198176749973 0.571428571428571 12.1 12 1 pulmonary alveolar hemorrhage 0.0776499730310143 0.329333858336996 1.05198176749973 0.571428571428571 12.1 12 1 premature death 5.76461715939177e-40 4.77982839466234e-37 1.04984359317554 0.570267131242741 12.1 12 1 double outlet right ventricle 3.28003243210276e-06 8.20008108025691e-05 1.0495238661738 0.570093457943925 12.1 12 1 abnormal somite development 6.27227829051045e-05 0.00109106938794719 1.04865271127347 0.569620253164557 12.1 12 1 abnormal visceral yolk sac morphology 6.27227829051045e-05 0.00109106938794719 1.04865271127347 0.569620253164557 12.1 12 1 abnormal trophoblast layer morphology 0.00126673689268208 0.0145880000951235 1.04682499412963 0.568627450980392 12.1 12 1 decreased blood urea nitrogen level 0.00272787476488525 0.0269804710841036 1.04600459836621 0.568181818181818 12.1 12 1 abnormal neural tube morphology 1.57515554792767e-08 6.87403407977206e-07 1.04548805288553 0.567901234567901 12.1 12 1 decreased heart weight 5.78341105501605e-05 0.00102758821423946 1.04548805288553 0.567901234567901 12.1 12 1 abnormal vocalization 0.00593606447598039 0.049633480282357 1.04487378258419 0.567567567567568 12.1 12 1 preweaning lethality, incomplete penetrance 3.66559875354237e-19 6.75420511069382e-17 1.04426551981636 0.567237163814181 12.1 12 1 epidermal hyperplasia 0.000544946564284257 0.00715332231481313 1.04321525277057 0.566666666666667 12.1 12 1 abnormal cellular respiration 0.0131079767992591 0.0935612404251278 1.04321525277057 0.566666666666667 12.1 12 1 lung inflammation 2.6663067320498e-07 8.8432506612985e-06 1.0423128174308 0.566176470588235 12.1 12 1 abnormal blood vessel morphology 1.1887545288893e-07 4.31682757753597e-06 1.04109919749111 0.56551724137931 12.1 12 1 abnormal myelin sheath morphology 0.00249816973618565 0.0250068298541723 1.04054718307039 0.565217391304348 12.1 12 1 conjunctivitis 0.0295891860690922 0.166146953378932 1.04054718307039 0.565217391304348 12.1 12 1 pancreas inflammation 0.0295891860690922 0.166146953378932 1.04054718307039 0.565217391304348 12.1 12 1 abnormal nervous system physiology 2.38278072798444e-06 6.14214203198062e-05 1.04054718307039 0.565217391304348 12.1 12 1 impaired macrophage chemotaxis 0.00542047064310586 0.0464145291728944 1.03849482176255 0.564102564102564 12.1 12 1 decreased circulating LDL cholesterol level 0.000459211037706837 0.00615788386143266 1.03554455238255 0.5625 12.1 12 1 neonatal lethality 0.0119192738715648 0.0872992922226083 1.03554455238255 0.5625 12.1 12 1 bradykinesia 0.0119192738715648 0.0872992922226083 1.03554455238255 0.5625 12.1 12 1 abnormal tympanic ring morphology 0.0693024712442412 0.300330831393815 1.03554455238255 0.5625 12.1 12 1 abnormal hair follicle orientation 0.0693024712442412 0.300330831393815 1.03554455238255 0.5625 12.1 12 1 abnormal meiosis 0.0693024712442412 0.300330831393815 1.03554455238255 0.5625 12.1 12 1 abnormal olfaction 0.0693024712442412 0.300330831393815 1.03554455238255 0.5625 12.1 12 1 dystonia 0.0693024712442412 0.300330831393815 1.03554455238255 0.5625 12.1 12 1 abnormal thoracic cage shape 0.0693024712442412 0.300330831393815 1.03554455238255 0.5625 12.1 12 1 decreased bone mineral content 4.24731344437332e-10 2.57687614460454e-08 1.03554455238255 0.5625 12.1 12 1 retinal degeneration 1.98492968372512e-05 0.000416667728967615 1.03554455238255 0.5625 12.1 12 1 decreased hematocrit 1.77855250286998e-07 6.23119626885784e-06 1.03396838106994 0.561643835616438 12.1 12 1 increased macrophage cell number 0.000976351076637611 0.0114830889037166 1.03352594701728 0.56140350877193 12.1 12 1 increased bone trabecula number 0.00494451290863348 0.0440841428681928 1.03273819858205 0.560975609756098 12.1 12 1 decreased bone mineral density 2.92239589249729e-12 2.30776501034508e-10 1.03121896945697 0.56015037593985 12.1 12 1 kinked tail 1.54179716552084e-05 0.000337904885394985 1.0287762873343 0.558823529411765 12.1 12 1 increased osteoclast cell number 0.000817460970123196 0.0100416501885504 1.02611336338088 0.557377049180328 12.1 12 1 cleft palate 1.2273552202562e-06 3.46649562302009e-05 1.02588298319153 0.557251908396947 12.1 12 1 abnormal heart development 1.08033531690798e-07 3.95196191295381e-06 1.02534931768961 0.556962025316456 12.1 12 1 abnormal nervous system morphology 0.00015368212179335 0.00239676663298406 1.02534931768961 0.556962025316456 12.1 12 1 decreased susceptibility to hepatic steatosis 0.000747280848809378 0.00941195499449786 1.02276005173585 0.555555555555556 12.1 12 1 abnormal axon morphology 1.19258902801278e-05 0.000267871654308551 1.02276005173585 0.555555555555556 12.1 12 1 abnormal neuron morphology 2.7059746908343e-05 0.000549478534159209 1.02276005173585 0.555555555555556 12.1 12 1 abnormal inflammatory response 0.000323320862405483 0.00455671753673449 1.02276005173585 0.555555555555556 12.1 12 1 impaired limb coordination 0.00174148522554661 0.0181632893020847 1.02276005173585 0.555555555555556 12.1 12 1 rectal prolapse 0.0241284455785662 0.145149959798509 1.02276005173585 0.555555555555556 12.1 12 1 cryptorchism 0.0241284455785662 0.145149959798509 1.02276005173585 0.555555555555556 12.1 12 1 decreased bone ossification 0.0241284455785662 0.145149959798509 1.02276005173585 0.555555555555556 12.1 12 1 abnormal radius morphology 0.0618637294022572 0.272123831809221 1.02276005173585 0.555555555555556 12.1 12 1 absent allantois 0.0618637294022572 0.272123831809221 1.02276005173585 0.555555555555556 12.1 12 1 increased circulating glycerol level 0.0618637294022572 0.272123831809221 1.02276005173585 0.555555555555556 12.1 12 1 increased susceptibility to autoimmune disorder 0.0618637294022572 0.272123831809221 1.02276005173585 0.555555555555556 12.1 12 1 small thoracic cage 0.0618637294022572 0.272123831809221 1.02276005173585 0.555555555555556 12.1 12 1 primary atelectasis 0.0618637294022572 0.272123831809221 1.02276005173585 0.555555555555556 12.1 12 1 abnormal sympathetic neuron morphology 0.175069998663254 0.538635277272536 1.02276005173585 0.555555555555556 12.1 12 1 abnormal cholinergic neuron morphology 0.175069998663254 0.538635277272536 1.02276005173585 0.555555555555556 12.1 12 1 abnormal kindling response 0.175069998663254 0.538635277272536 1.02276005173585 0.555555555555556 12.1 12 1 abnormal posterior semicircular canal morphology 0.175069998663254 0.538635277272536 1.02276005173585 0.555555555555556 12.1 12 1 decreased muscle weight 0.175069998663254 0.538635277272536 1.02276005173585 0.555555555555556 12.1 12 1 abnormal gallbladder physiology 0.175069998663254 0.538635277272536 1.02276005173585 0.555555555555556 12.1 12 1 hemothorax 0.175069998663254 0.538635277272536 1.02276005173585 0.555555555555556 12.1 12 1 abnormal inguinal fat pad morphology 0.175069998663254 0.538635277272536 1.02276005173585 0.555555555555556 12.1 12 1 abnormal optic chiasm morphology 0.175069998663254 0.538635277272536 1.02276005173585 0.555555555555556 12.1 12 1 abnormal cerebellar layer morphology 0.175069998663254 0.538635277272536 1.02276005173585 0.555555555555556 12.1 12 1 retropulsion 0.175069998663254 0.538635277272536 1.02276005173585 0.555555555555556 12.1 12 1 shortened ST segment 0.175069998663254 0.538635277272536 1.02276005173585 0.555555555555556 12.1 12 1 fusion of atlas and occipital bones 0.175069998663254 0.538635277272536 1.02276005173585 0.555555555555556 12.1 12 1 decreased susceptibility to parasitic infection induced morbidity/mortality 0.175069998663254 0.538635277272536 1.02276005173585 0.555555555555556 12.1 12 1 abnormal lung lobe morphology 0.175069998663254 0.538635277272536 1.02276005173585 0.555555555555556 12.1 12 1 decreased bone trabecular spacing 0.175069998663254 0.538635277272536 1.02276005173585 0.555555555555556 12.1 12 1 abnormal coronary sinus connection 0.175069998663254 0.538635277272536 1.02276005173585 0.555555555555556 12.1 12 1 increased cardiac muscle glycogen level 0.175069998663254 0.538635277272536 1.02276005173585 0.555555555555556 12.1 12 1 cerebellum atrophy 0.175069998663254 0.538635277272536 1.02276005173585 0.555555555555556 12.1 12 1 decreased total body fat amount 3.10548411861278e-14 3.15301703879563e-12 1.01969789589233 0.553892215568862 12.1 12 1 hepatic necrosis 0.00373553924377009 0.0339749684419674 1.01840788130293 0.553191489361702 12.1 12 1 increased respiratory quotient 0.00373553924377009 0.0339749684419674 1.01840788130293 0.553191489361702 12.1 12 1 persistence of hyaloid vascular system 0.00891651698720306 0.0705241208447301 1.01737710409513 0.552631578947368 12.1 12 1 rib fusion 0.000623491212344501 0.00805642920893184 1.01665402157623 0.552238805970149 12.1 12 1 abnormal retinal pigmentation 0.000107907389983036 0.00176591863541317 1.01570653413767 0.551724137931034 12.1 12 1 decreased granulocyte number 0.021771647040898 0.139400185364823 1.01570653413767 0.551724137931034 12.1 12 1 short sternum 0.021771647040898 0.139400185364823 1.01570653413767 0.551724137931034 12.1 12 1 polychromatophilia 0.021771647040898 0.139400185364823 1.01570653413767 0.551724137931034 12.1 12 1 male infertility 4.15957516387507e-20 8.27755457611139e-18 1.01381344293339 0.550695825049702 12.1 12 1 enlarged liver 3.96226024397011e-05 0.000741061831344034 1.01253245121849 0.55 12.1 12 1 abnormal female reproductive system morphology 0.00808510760873126 0.0642546491268978 1.01253245121849 0.55 12.1 12 1 abnormal cell proliferation 0.055248055327168 0.252164289222625 1.01253245121849 0.55 12.1 12 1 abnormal circulating enzyme level 0.055248055327168 0.252164289222625 1.01253245121849 0.55 12.1 12 1 abnormal optic stalk morphology 0.055248055327168 0.252164289222625 1.01253245121849 0.55 12.1 12 1 abnormal response to tactile stimuli 0.055248055327168 0.252164289222625 1.01253245121849 0.55 12.1 12 1 abnormal induced retinal neovascularization 0.055248055327168 0.252164289222625 1.01253245121849 0.55 12.1 12 1 abnormal ovary morphology 0.000519288770124218 0.00683455458033858 1.01123599481488 0.549295774647887 12.1 12 1 perinatal lethality, incomplete penetrance 1.09292402997691e-09 6.04144116570571e-08 1.01008868826302 0.548672566371681 12.1 12 1 prenatal lethality 0.00120239744099806 0.0139438864078446 1.00956314784248 0.548387096774194 12.1 12 1 increased eosinophil cell number 0.00120239744099806 0.0139438864078446 1.00956314784248 0.548387096774194 12.1 12 1 abnormal object recognition memory 0.0196397439661118 0.128057308298042 1.00956314784248 0.548387096774194 12.1 12 1 pale kidney 0.0196397439661118 0.128057308298042 1.00956314784248 0.548387096774194 12.1 12 1 cachexia 3.31342133629133e-05 0.000646442005805857 1.00899212796248 0.548076923076923 12.1 12 1 abnormal fertility/fecundity 0.000473648601612621 0.00630053955353688 1.00874964006824 0.547945205479452 12.1 12 1 decreased percent body fat/body weight 0.000473648601612621 0.00630053955353688 1.00874964006824 0.547945205479452 12.1 12 1 abnormal coat/ hair morphology 0.00280875787340667 0.0277253381353139 1.00732216416248 0.547169811320755 12.1 12 1 decreased neutrophil cell number 1.22300457063998e-05 0.000271627131202407 1.00702528170914 0.547008547008547 12.1 12 1 increased heart weight 2.01267590530572e-06 5.29791673486558e-05 1.00657248257168 0.546762589928058 12.1 12 1 increased oxygen consumption 0.000171803317904635 0.00264619661478502 1.00611046949829 0.546511627906977 12.1 12 1 teratozoospermia 0.000156757835133946 0.00243709446809807 1.00416441443156 0.545454545454545 12.1 12 1 decreased circulating calcium level 0.00255225699547951 0.0254458488026264 1.00416441443156 0.545454545454545 12.1 12 1 omphalocele 0.00664070513082966 0.0538947928644006 1.00416441443156 0.545454545454545 12.1 12 1 abnormal facial nerve morphology 0.0493680324191546 0.241738150871352 1.00416441443156 0.545454545454545 12.1 12 1 increased body size 0.0493680324191546 0.241738150871352 1.00416441443156 0.545454545454545 12.1 12 1 intracerebral hemorrhage 0.0493680324191546 0.241738150871352 1.00416441443156 0.545454545454545 12.1 12 1 abnormal oogenesis 0.0493680324191546 0.241738150871352 1.00416441443156 0.545454545454545 12.1 12 1 testis hypoplasia 0.0493680324191546 0.241738150871352 1.00416441443156 0.545454545454545 12.1 12 1 aphakia 0.0493680324191546 0.241738150871352 1.00416441443156 0.545454545454545 12.1 12 1 parakeratosis 0.0493680324191546 0.241738150871352 1.00416441443156 0.545454545454545 12.1 12 1 abnormal female reproductive system physiology 0.0493680324191546 0.241738150871352 1.00416441443156 0.545454545454545 12.1 12 1 pulmonary vascular congestion 0.0493680324191546 0.241738150871352 1.00416441443156 0.545454545454545 12.1 12 1 abnormal sebaceous gland morphology 0.152034675119305 0.47993179487217 1.00416441443156 0.545454545454545 12.1 12 1 abnormal food preference 0.152034675119305 0.47993179487217 1.00416441443156 0.545454545454545 12.1 12 1 fatigue 0.152034675119305 0.47993179487217 1.00416441443156 0.545454545454545 12.1 12 1 pharyngeal arch hypoplasia 0.152034675119305 0.47993179487217 1.00416441443156 0.545454545454545 12.1 12 1 abnormal platelet aggregation 0.152034675119305 0.47993179487217 1.00416441443156 0.545454545454545 12.1 12 1 abnormal superovulation 0.152034675119305 0.47993179487217 1.00416441443156 0.545454545454545 12.1 12 1 abnormal pulmonary alveolar sac morphology 0.152034675119305 0.47993179487217 1.00416441443156 0.545454545454545 12.1 12 1 increased subcutaneous adipose tissue amount 0.152034675119305 0.47993179487217 1.00416441443156 0.545454545454545 12.1 12 1 decreased core body temperature 0.152034675119305 0.47993179487217 1.00416441443156 0.545454545454545 12.1 12 1 decreased embryonic cilium length 0.152034675119305 0.47993179487217 1.00416441443156 0.545454545454545 12.1 12 1 decreased brown adipose tissue amount 0.0177139241981633 0.117502363847816 1.00416441443156 0.545454545454545 12.1 12 1 abnormal locomotor coordination 0.0177139241981633 0.117502363847816 1.00416441443156 0.545454545454545 12.1 12 1 decreased circulating glucose level 3.15331168025674e-11 2.34145158347422e-09 1.0029646958958 0.544802867383513 12.1 12 1 postnatal growth retardation 2.21195924038442e-22 5.79184064258552e-20 0.998695109342065 0.542483660130719 12.1 12 1 decreased body weight 4.67788443813363e-44 5.8181187699287e-41 0.997810654674119 0.542003231017771 12.1 12 1 increased body temperature 0.0441413519653184 0.221597604467668 0.997191050442453 0.541666666666667 12.1 12 1 abnormal neuromuscular synapse morphology 0.000750887206519087 0.0094139082699101 0.997191050442453 0.541666666666667 12.1 12 1 decreased body size 1.71960702784923e-28 7.77731360322719e-26 0.996614306052376 0.541353383458647 12.1 12 1 increased circulating phosphate level 0.0144083901405892 0.101388601060016 0.995117888175421 0.540540540540541 12.1 12 1 increased trabecular bone volume 0.0144083901405892 0.101388601060016 0.995117888175421 0.540540540540541 12.1 12 1 abnormal brain morphology 7.487416456788e-07 2.1656916786349e-05 0.994808845353006 0.540372670807453 12.1 12 1 abnormal interventricular septum morphology 0.00493517212308969 0.0440798587295713 0.994122770287246 0.54 12.1 12 1 decreased circulating HDL cholesterol level 1.11168595238977e-05 0.000253698973079775 0.992396862699942 0.5390625 12.1 12 1 absent corpus luteum 0.00446912598849003 0.0401383256672042 0.991290511682439 0.538461538461538 12.1 12 1 abnormal female meiosis 0.00446912598849003 0.0401383256672042 0.991290511682439 0.538461538461538 12.1 12 1 decreased trabecular bone volume 0.0129952377219831 0.0932919302552181 0.991290511682439 0.538461538461538 12.1 12 1 thick skin 0.0394932128264722 0.213796228304352 0.991290511682439 0.538461538461538 12.1 12 1 pulmonary edema 0.0394932128264722 0.213796228304352 0.991290511682439 0.538461538461538 12.1 12 1 increased foot pad pigmentation 0.132768606058822 0.428355262738416 0.991290511682439 0.538461538461538 12.1 12 1 uterus hypoplasia 0.132768606058822 0.428355262738416 0.991290511682439 0.538461538461538 12.1 12 1 tight skin 0.132768606058822 0.428355262738416 0.991290511682439 0.538461538461538 12.1 12 1 abnormal pulmonary alveolus epithelial cell morphology 0.132768606058822 0.428355262738416 0.991290511682439 0.538461538461538 12.1 12 1 small otic vesicle 0.132768606058822 0.428355262738416 0.991290511682439 0.538461538461538 12.1 12 1 increased prostaglandin level 0.132768606058822 0.428355262738416 0.991290511682439 0.538461538461538 12.1 12 1 limb grasping 1.94223905735861e-07 6.75709042682455e-06 0.991290511682439 0.538461538461538 12.1 12 1 decreased white adipose tissue amount 0.00143031260174167 0.0162461305791434 0.989176885857956 0.537313432835821 12.1 12 1 weight loss 3.95523910179044e-07 1.26950416331661e-05 0.988862861449747 0.537142857142857 12.1 12 1 decreased birth weight 0.000169428166611677 0.00262587267567942 0.988309186835273 0.536842105263158 12.1 12 1 sparse hair 0.000466582172505028 0.0062399094306788 0.987836537774137 0.536585365853659 12.1 12 1 abnormal mammary gland development 0.0117215856825287 0.0862646283588467 0.987836537774137 0.536585365853659 12.1 12 1 scaly skin 0.0117215856825287 0.0862646283588467 0.987836537774137 0.536585365853659 12.1 12 1 arrest of spermatogenesis 0.000424062138621182 0.00578002504011063 0.986232907030998 0.535714285714286 12.1 12 1 decreased circulating cholesterol level 2.74019987093277e-07 9.02814195886791e-06 0.985873623640458 0.53551912568306 12.1 12 1 ataxia 7.77707873755986e-08 2.97622820918156e-06 0.984279970581431 0.534653465346535 12.1 12 1 abnormal bone structure 1.72856640472879e-07 6.09901976136578e-06 0.982485562651951 0.533678756476684 12.1 12 1 increased circulating HDL cholesterol level 0.000105550267542535 0.00173304482186176 0.981849649666415 0.533333333333333 12.1 12 1 delayed bone ossification 0.000969860760988921 0.0114337850377248 0.981849649666415 0.533333333333333 12.1 12 1 increased erythrocyte cell number 0.00300384865248326 0.0289615252831477 0.981849649666415 0.533333333333333 12.1 12 1 decreased salivation 0.116445948646104 0.417444052508226 0.981849649666415 0.533333333333333 12.1 12 1 abnormal prostate gland morphology 0.116445948646104 0.417444052508226 0.981849649666415 0.533333333333333 12.1 12 1 audiogenic seizures 0.116445948646104 0.417444052508226 0.981849649666415 0.533333333333333 12.1 12 1 placental labyrinth hypoplasia 0.116445948646104 0.417444052508226 0.981849649666415 0.533333333333333 12.1 12 1 joint inflammation 0.116445948646104 0.417444052508226 0.981849649666415 0.533333333333333 12.1 12 1 absent chorion 0.116445948646104 0.417444052508226 0.981849649666415 0.533333333333333 12.1 12 1 bicuspid aortic valve 0.116445948646104 0.417444052508226 0.981849649666415 0.533333333333333 12.1 12 1 abnormal rib morphology 1.18709306792318e-05 0.000267871654308551 0.981849649666415 0.533333333333333 12.1 12 1 increased circulating follicle stimulating hormone level 0.0283896100732653 0.159952786086631 0.978014299472406 0.53125 12.1 12 1 abnormal liver morphology 7.08723704584945e-07 2.06193007620474e-05 0.977050105289554 0.53072625698324 12.1 12 1 polydactyly 0.000216748295304737 0.00326548176570219 0.976840212678321 0.530612244897959 12.1 12 1 short tail 0.000657082793941523 0.00842522396870896 0.975934892740714 0.530120481927711 12.1 12 1 decreased grip strength 5.17480891867038e-08 2.01130268518634e-06 0.975124652065961 0.529680365296804 12.1 12 1 abnormal lung development 0.000596098726869611 0.00772289366191749 0.97463016694828 0.529411764705882 12.1 12 1 lung hemorrhage 0.0254608130963325 0.151154588489563 0.97463016694828 0.529411764705882 12.1 12 1 abnormal nervous system development 0.0254608130963325 0.151154588489563 0.97463016694828 0.529411764705882 12.1 12 1 abnormal vagus nerve morphology 0.102484205102707 0.410184167647602 0.97463016694828 0.529411764705882 12.1 12 1 aminoaciduria 0.102484205102707 0.410184167647602 0.97463016694828 0.529411764705882 12.1 12 1 abnormal testis development 0.102484205102707 0.410184167647602 0.97463016694828 0.529411764705882 12.1 12 1 abnormal melanosome morphology 0.102484205102707 0.410184167647602 0.97463016694828 0.529411764705882 12.1 12 1 enhanced behavioral response to cocaine 0.102484205102707 0.410184167647602 0.97463016694828 0.529411764705882 12.1 12 1 abnormal survival 0.102484205102707 0.410184167647602 0.97463016694828 0.529411764705882 12.1 12 1 decreased body fat mass 0.102484205102707 0.410184167647602 0.97463016694828 0.529411764705882 12.1 12 1 reduced male fertility 3.56369379674762e-08 1.44141273486337e-06 0.973198991960103 0.52863436123348 12.1 12 1 domed cranium 0.00182801628685067 0.0190259017302973 0.973083134937251 0.528571428571429 12.1 12 1 abnormal placenta development 0.00632873827738343 0.0519804544398945 0.972586917122393 0.528301886792453 12.1 12 1 increased circulating bilirubin level 0.00632873827738343 0.0519804544398945 0.972586917122393 0.528301886792453 12.1 12 1 abnormal forebrain development 0.00165530124173129 0.0174350154144623 0.971622049149057 0.527777777777778 12.1 12 1 abnormal uterus morphology 0.0228462590610405 0.139965080134917 0.971622049149057 0.527777777777778 12.1 12 1 decreased total retina thickness 0.0205104714221295 0.132004651132075 0.968930575328699 0.526315789473684 12.1 12 1 irregular coat pigmentation 0.0904535669565408 0.375318178155789 0.968930575328699 0.526315789473684 12.1 12 1 short vibrissae 0.0904535669565408 0.375318178155789 0.968930575328699 0.526315789473684 12.1 12 1 oliguria 0.0904535669565408 0.375318178155789 0.968930575328699 0.526315789473684 12.1 12 1 abnormal sternebra morphology 0.0904535669565408 0.375318178155789 0.968930575328699 0.526315789473684 12.1 12 1 decreased eye pigmentation 0.0904535669565408 0.375318178155789 0.968930575328699 0.526315789473684 12.1 12 1 decreased susceptibility to weight gain 0.0904535669565408 0.375318178155789 0.968930575328699 0.526315789473684 12.1 12 1 shortened RR interval 0.0904535669565408 0.375318178155789 0.968930575328699 0.526315789473684 12.1 12 1 abnormal pancreas morphology 0.0165540027957246 0.110397002558619 0.964316620208087 0.523809523809524 12.1 12 1 abnormal tumor vascularization 0.0800260732159154 0.338833799361004 0.964316620208087 0.523809523809524 12.1 12 1 increased bone ossification 0.0800260732159154 0.338833799361004 0.964316620208087 0.523809523809524 12.1 12 1 abnormal heart morphology 6.16237058233574e-08 2.37657315093956e-06 0.964316620208087 0.523809523809524 12.1 12 1 edema 2.99898485997647e-06 7.57357851694566e-05 0.963297258030277 0.523255813953488 12.1 12 1 abnormal lipid homeostasis 4.6435736346782e-05 0.000858802187082678 0.962967925634369 0.523076923076923 12.1 12 1 abnormal astrocyte morphology 0.0148815406811126 0.103031026180595 0.962324230496913 0.522727272727273 12.1 12 1 decreased macrophage cell number 0.0148815406811126 0.103031026180595 0.962324230496913 0.522727272727273 12.1 12 1 abnormal postnatal growth 0.0709449557101319 0.306647397617642 0.960505092064972 0.521739130434783 12.1 12 1 abnormal nasal cavity morphology 0.0709449557101319 0.306647397617642 0.960505092064972 0.521739130434783 12.1 12 1 abnormal sacral vertebrae morphology 0.0709449557101319 0.306647397617642 0.960505092064972 0.521739130434783 12.1 12 1 enlarged heart 8.43105396250946e-08 3.17761314117307e-06 0.960160083052017 0.521551724137931 12.1 12 1 abnormal osteoclast morphology 0.0120406488258605 0.087448507895848 0.958837548502359 0.520833333333333 12.1 12 1 short stride length 0.0108364959337946 0.0820571800161767 0.957303408424755 0.52 12.1 12 1 abnormal thyroid gland morphology 0.0630050799341609 0.275681858111214 0.957303408424755 0.52 12.1 12 1 abnormal nest building behavior 0.0630050799341609 0.275681858111214 0.957303408424755 0.52 12.1 12 1 abnormal primitive streak morphology 0.0630050799341609 0.275681858111214 0.957303408424755 0.52 12.1 12 1 abnormal cochlear outer hair cell morphology 0.0630050799341609 0.275681858111214 0.957303408424755 0.52 12.1 12 1 decreased placenta weight 0.0630050799341609 0.275681858111214 0.957303408424755 0.52 12.1 12 1 decreased acute inflammation 0.0630050799341609 0.275681858111214 0.957303408424755 0.52 12.1 12 1 abnormal skin appearance 0.0560398852472942 0.253090695443525 0.954576048286793 0.518518518518518 12.1 12 1 thick interventricular septum 0.0560398852472942 0.253090695443525 0.954576048286793 0.518518518518518 12.1 12 1 reduced fertility 4.30795997447661e-05 0.000799705256456012 0.953594983488965 0.517985611510791 12.1 12 1 reduced female fertility 1.71262250493376e-07 6.08592640146105e-06 0.952224875754067 0.517241379310345 12.1 12 1 abnormal microglial cell morphology 0.0499123339281646 0.243444962051587 0.952224875754067 0.517241379310345 12.1 12 1 abnormal outer ear morphology 0.0499123339281646 0.243444962051587 0.952224875754067 0.517241379310345 12.1 12 1 increased susceptibility to induced arthritis 0.0499123339281646 0.243444962051587 0.952224875754067 0.517241379310345 12.1 12 1 small ovary 0.000928870338809943 0.01102894972692 0.95082967447091 0.516483516483517 12.1 12 1 abnormal podocyte morphology 0.0445084409866359 0.222766090451221 0.950177080322338 0.516129032258065 12.1 12 1 small cranium 0.0445084409866359 0.222766090451221 0.950177080322338 0.516129032258065 12.1 12 1 abnormal enzyme/coenzyme activity 1.79963188360078e-05 0.00037937155173364 0.949798825115203 0.515923566878981 12.1 12 1 neonatal lethality, incomplete penetrance 4.49152121964212e-08 1.78762544541756e-06 0.948806632610334 0.515384615384615 12.1 12 1 insulin resistance 8.62263407641862e-05 0.00146408206587654 0.948377502518697 0.515151515151515 12.1 12 1 diarrhea 0.0397325263155611 0.214100317404677 0.948377502518697 0.515151515151515 12.1 12 1 female infertility 3.37114333609893e-08 1.39761984142435e-06 0.948167777285941 0.515037593984962 12.1 12 1 abnormal intestinal goblet cell morphology 0.0355036521890491 0.194956589007195 0.946783590749758 0.514285714285714 12.1 12 1 decreased triglyceride level 0.0355036521890491 0.194956589007195 0.946783590749758 0.514285714285714 12.1 12 1 decreased bone volume 0.0355036521890491 0.194956589007195 0.946783590749758 0.514285714285714 12.1 12 1 increased susceptibility to bacterial infection induced morbidity/mortality 0.00346582682505785 0.0321089170477892 0.946053047855661 0.513888888888889 12.1 12 1 abnormal hair follicle development 0.0317528984770725 0.176898846498808 0.94536199376665 0.513513513513513 12.1 12 1 abnormal skeleton morphology 0.000281989595023798 0.0039968610690695 0.944496673863889 0.51304347826087 12.1 12 1 liver fibrosis 0.0254578934884362 0.151154588489563 0.942934876966222 0.51219512195122 12.1 12 1 increased tumor growth/size 0.0254578934884362 0.151154588489563 0.942934876966222 0.51219512195122 12.1 12 1 abnormal male reproductive system morphology 0.0228189444790445 0.139965080134917 0.941890652296271 0.511627906976744 12.1 12 1 abnormal left-right axis patterning 0.0228189444790445 0.139965080134917 0.941890652296271 0.511627906976744 12.1 12 1 abnormal homeostasis 0.0228189444790445 0.139965080134917 0.941890652296271 0.511627906976744 12.1 12 1 impaired macrophage phagocytosis 0.0228189444790445 0.139965080134917 0.941890652296271 0.511627906976744 12.1 12 1 decreased oxygen consumption 0.0228189444790445 0.139965080134917 0.941890652296271 0.511627906976744 12.1 12 1 hyperglycemia 0.0015373343424471 0.016883528374557 0.941404138529589 0.511363636363636 12.1 12 1 abnormal ovarian follicle morphology 0.020466305490295 0.132004651132075 0.940939247596981 0.511111111111111 12.1 12 1 abnormal myocardial trabeculae morphology 0.020466305490295 0.132004651132075 0.940939247596981 0.511111111111111 12.1 12 1 abnormal cell migration 0.020466305490295 0.132004651132075 0.940939247596981 0.511111111111111 12.1 12 1 abnormal liver physiology 0.000840806257882068 0.0102274110830398 0.93889372749351 0.51 12.1 12 1 abnormal thrombosis 0.0148150829427584 0.103031026180595 0.938532753357603 0.509803921568627 12.1 12 1 increased circulating calcium level 0.0119724492846027 0.0872992922226083 0.937220120136124 0.509090909090909 12.1 12 1 decreased susceptibility to induced arthritis 0.0107694547229645 0.0816738372663844 0.936632889484409 0.508771929824561 12.1 12 1 abnormal facial morphology 0.0107694547229645 0.0816738372663844 0.936632889484409 0.508771929824561 12.1 12 1 increased circulating aspartate transaminase level 0.00785568545135614 0.0625312561927949 0.935094904444205 0.507936507936508 12.1 12 1 increased circulating free fatty acid level 0.00518112428831497 0.045460482071194 0.933448610598353 0.507042253521127 12.1 12 1 increased exploration in new environment 0.00309720659791406 0.0298038739354399 0.931848047137107 0.506172839506173 12.1 12 1 hypoglycemia 0.00168154852235749 0.0175750081906061 0.930381724482289 0.505376344086022 12.1 12 1 alopecia 0.00151968971559247 0.0167647928757816 0.930173352315551 0.505263157894737 12.1 12 1 abnormal motor coordination/ balance 0.00124176443095997 0.014366925683781 0.929781865214408 0.505050505050505 12.1 12 1 abnormal vertebrae morphology 0.000751220418724484 0.0094139082699101 0.928928854328891 0.504587155963303 12.1 12 1 abnormal bone mineralization 0.000412552035353588 0.00563858894473654 0.9280913527322 0.504132231404959 12.1 12 1 abnormal locomotor behavior 0.00246530909676385 0.0247276466862906 0.920484046562265 0.5 12.1 12 1 kidney inflammation 0.0221465543713274 0.139965080134917 0.920484046562265 0.5 12.1 12 1 atrial septal defect 0.0275492052458835 0.155393759748606 0.920484046562265 0.5 12.1 12 1 abnormal reproductive system morphology 0.0343617841811478 0.189523144458105 0.920484046562265 0.5 12.1 12 1 abnormal crypts of Lieberkuhn morphology 0.0606272719000063 0.268107269068917 0.920484046562265 0.5 12.1 12 1 abnormal heart atrium morphology 0.0606272719000063 0.268107269068917 0.920484046562265 0.5 12.1 12 1 absent mandible 0.163589426047968 0.511859996596629 0.920484046562265 0.5 12.1 12 1 abnormal mouth morphology 0.163589426047968 0.511859996596629 0.920484046562265 0.5 12.1 12 1 white spotting 0.163589426047968 0.511859996596629 0.920484046562265 0.5 12.1 12 1 increased pancreatic beta cell number 0.163589426047968 0.511859996596629 0.920484046562265 0.5 12.1 12 1 abnormal amnion morphology 0.163589426047968 0.511859996596629 0.920484046562265 0.5 12.1 12 1 abnormal Langerhans cell physiology 0.163589426047968 0.511859996596629 0.920484046562265 0.5 12.1 12 1 decreased creatinine clearance 0.163589426047968 0.511859996596629 0.920484046562265 0.5 12.1 12 1 abnormal posture 0.00455757007831474 0.0408538939452538 0.920484046562264 0.5 12.1 12 1 abnormal skin morphology 0.00943695721216888 0.0722290186623695 0.920484046562264 0.5 12.1 12 1 abnormal skin condition 0.0198740844287209 0.129270728381752 0.920484046562264 0.5 12.1 12 1 abnormal intestinal epithelium morphology 0.024692984685834 0.14800915519521 0.920484046562264 0.5 12.1 12 1 oligodactyly 0.024692984685834 0.14800915519521 0.920484046562264 0.5 12.1 12 1 abnormal gametogenesis 0.0307563482769763 0.171539050087396 0.920484046562264 0.5 12.1 12 1 embryonic lethality, incomplete penetrance 0.0307563482769763 0.171539050087396 0.920484046562264 0.5 12.1 12 1 abnormal endoderm development 0.0540042395347897 0.252164289222625 0.920484046562264 0.5 12.1 12 1 abnormal fat pad morphology 0.0681516833964155 0.296895468386311 0.920484046562264 0.5 12.1 12 1 abnormal ovulation 0.0767229642667339 0.328765501487512 0.920484046562264 0.5 12.1 12 1 abnormal renal tubule epithelium morphology 0.0767229642667339 0.328765501487512 0.920484046562264 0.5 12.1 12 1 ventricular hypoplasia 0.0865169470418497 0.3632996524593 0.920484046562264 0.5 12.1 12 1 decreased body height 0.0977485594549454 0.394403149463385 0.920484046562264 0.5 12.1 12 1 curly vibrissae 0.0977485594549454 0.394403149463385 0.920484046562264 0.5 12.1 12 1 abnormal vasodilation 0.0977485594549454 0.394403149463385 0.920484046562264 0.5 12.1 12 1 blindness 0.0977485594549454 0.394403149463385 0.920484046562264 0.5 12.1 12 1 abnormal truncus arteriosus septation 0.0977485594549454 0.394403149463385 0.920484046562264 0.5 12.1 12 1 abnormal long bone epiphysis morphology 0.110684114012676 0.417444052508226 0.920484046562264 0.5 12.1 12 1 abnormal pericardium morphology 0.125659078585913 0.417444052508226 0.920484046562264 0.5 12.1 12 1 abnormal tail movements 0.110684114012676 0.417444052508226 0.920484046562264 0.5 12.1 12 1 anencephaly 0.125659078585913 0.417444052508226 0.920484046562264 0.5 12.1 12 1 abnormal hair texture 0.125659078585913 0.417444052508226 0.920484046562264 0.5 12.1 12 1 abnormal vascular branching morphogenesis 0.110684114012676 0.417444052508226 0.920484046562264 0.5 12.1 12 1 abnormal circulating lipid level 0.110684114012676 0.417444052508226 0.920484046562264 0.5 12.1 12 1 decreased circulating VLDL cholesterol level 0.125659078585913 0.417444052508226 0.920484046562264 0.5 12.1 12 1 rough coat 0.110684114012676 0.417444052508226 0.920484046562264 0.5 12.1 12 1 lowered ear position 0.143104680803158 0.457842949836469 0.920484046562264 0.5 12.1 12 1 abnormal mitral valve morphology 0.143104680803158 0.457842949836469 0.920484046562264 0.5 12.1 12 1 cortical renal glomerulopathies 0.143104680803158 0.457842949836469 0.920484046562264 0.5 12.1 12 1 right pulmonary isomerism 0.143104680803158 0.457842949836469 0.920484046562264 0.5 12.1 12 1 decreased activity of thyroid 0.143104680803158 0.457842949836469 0.920484046562264 0.5 12.1 12 1 long tibia 0.143104680803158 0.457842949836469 0.920484046562264 0.5 12.1 12 1 jerky movement 0.143104680803158 0.457842949836469 0.920484046562264 0.5 12.1 12 1 abnormal glycogen homeostasis 0.143104680803158 0.457842949836469 0.920484046562264 0.5 12.1 12 1 abnormal macrophage chemotaxis 0.143104680803158 0.457842949836469 0.920484046562264 0.5 12.1 12 1 decreased fluid intake 0.143104680803158 0.457842949836469 0.920484046562264 0.5 12.1 12 1 abnormal interparietal bone morphology 0.187887239086629 0.572406010077146 0.920484046562264 0.5 12.1 12 1 absent visceral yolk sac blood islands 0.187887239086629 0.572406010077146 0.920484046562264 0.5 12.1 12 1 abnormal adrenal gland secretion 0.187887239086629 0.572406010077146 0.920484046562264 0.5 12.1 12 1 abnormal hair cuticle 0.187887239086629 0.572406010077146 0.920484046562264 0.5 12.1 12 1 abnormal sagittal suture morphology 0.187887239086629 0.572406010077146 0.920484046562264 0.5 12.1 12 1 abnormal glucose tolerance 0.187887239086629 0.572406010077146 0.920484046562264 0.5 12.1 12 1 increased pulmonary respiratory rate 0.187887239086629 0.572406010077146 0.920484046562264 0.5 12.1 12 1 abnormal renal tubule epithelial cell primary cilium morphology 0.187887239086629 0.572406010077146 0.920484046562264 0.5 12.1 12 1 abnormal supraoccipital bone morphology 0.217096508815689 0.636051084497804 0.920484046562264 0.5 12.1 12 1 mesocardia 0.217096508815689 0.636051084497804 0.920484046562264 0.5 12.1 12 1 absent optic nerve 0.217096508815689 0.636051084497804 0.920484046562264 0.5 12.1 12 1 abnormal mating frequency 0.217096508815689 0.636051084497804 0.920484046562264 0.5 12.1 12 1 abnormal pilomotor reflex 0.217096508815689 0.636051084497804 0.920484046562264 0.5 12.1 12 1 abnormal respiratory function 0.217096508815689 0.636051084497804 0.920484046562264 0.5 12.1 12 1 abnormal corticospinal tract morphology 0.217096508815689 0.636051084497804 0.920484046562264 0.5 12.1 12 1 small thyroid gland 0.217096508815689 0.636051084497804 0.920484046562264 0.5 12.1 12 1 abnormal aorta elastic fiber morphology 0.217096508815689 0.636051084497804 0.920484046562264 0.5 12.1 12 1 decreased left ventricle systolic pressure 0.217096508815689 0.636051084497804 0.920484046562264 0.5 12.1 12 1 bowed ulna 0.217096508815689 0.636051084497804 0.920484046562264 0.5 12.1 12 1 increased skeletal muscle glycogen level 0.217096508815689 0.636051084497804 0.920484046562264 0.5 12.1 12 1 abnormal auchene hair morphology 0.252865254854202 0.698891468277585 0.920484046562264 0.5 12.1 12 1 increased cranium width 0.252865254854202 0.698891468277585 0.920484046562264 0.5 12.1 12 1 kidney hemorrhage 0.252865254854202 0.698891468277585 0.920484046562264 0.5 12.1 12 1 abnormal mammary gland physiology 0.252865254854202 0.698891468277585 0.920484046562264 0.5 12.1 12 1 decreased incidence of induced tumors 0.252865254854202 0.698891468277585 0.920484046562264 0.5 12.1 12 1 abnormal PNS synaptic transmission 0.252865254854202 0.698891468277585 0.920484046562264 0.5 12.1 12 1 abnormal tibialis anterior morphology 0.252865254854202 0.698891468277585 0.920484046562264 0.5 12.1 12 1 absent seminal vesicle 0.252865254854202 0.698891468277585 0.920484046562264 0.5 12.1 12 1 abnormal glial cell physiology 0.252865254854202 0.698891468277585 0.920484046562264 0.5 12.1 12 1 increased left ventricle diastolic pressure 0.252865254854202 0.698891468277585 0.920484046562264 0.5 12.1 12 1 abnormal embryonic erythrocyte morphology 0.252865254854202 0.698891468277585 0.920484046562264 0.5 12.1 12 1 increased susceptibility to atherosclerosis 0.252865254854202 0.698891468277585 0.920484046562264 0.5 12.1 12 1 decreased thyroxine level 0.252865254854202 0.698891468277585 0.920484046562264 0.5 12.1 12 1 abnormal vibrissa follicle morphology 0.252865254854202 0.698891468277585 0.920484046562264 0.5 12.1 12 1 abnormal heart and great artery attachment 0.252865254854202 0.698891468277585 0.920484046562264 0.5 12.1 12 1 aorta stenosis 0.252865254854202 0.698891468277585 0.920484046562264 0.5 12.1 12 1 fusion of atlas and odontoid process 0.252865254854202 0.698891468277585 0.920484046562264 0.5 12.1 12 1 decreased trabecular bone connectivity density 0.252865254854202 0.698891468277585 0.920484046562264 0.5 12.1 12 1 decreased macrophage apoptosis 0.252865254854202 0.698891468277585 0.920484046562264 0.5 12.1 12 1 decreased circulating lactate level 0.252865254854202 0.698891468277585 0.920484046562264 0.5 12.1 12 1 diluted coat color 0.0178442744815707 0.118052214821562 0.920484046562264 0.5 12.1 12 1 abnormal neuronal precursor proliferation 0.0178442744815707 0.118052214821562 0.920484046562264 0.5 12.1 12 1 abnormal compact bone morphology 0.0429953255320155 0.219843159231403 0.920484046562264 0.5 12.1 12 1 increased insulin sensitivity 0.000263380606195705 0.00380906545297568 0.914047095187703 0.496503496503497 12.1 12 1 abnormal eye morphology 0.000321123471134025 0.00453860587753345 0.913861859176924 0.496402877697842 12.1 12 1 abnormal cardiovascular system physiology 0.000432580231663421 0.00586399632840741 0.913563113881345 0.496240601503759 12.1 12 1 cataract 0.000786900873855418 0.00971422294647818 0.912876740392328 0.495867768595041 12.1 12 1 lethargy 0.00323239391426801 0.0304567419005367 0.91058636864224 0.494623655913978 12.1 12 1 abnormal glucose homeostasis 5.27097602407257e-05 0.000957047654005877 0.910368837259382 0.494505494505495 12.1 12 1 abnormal muscle physiology 0.00396532635150467 0.0359990850341893 0.91014152918516 0.49438202247191 12.1 12 1 impaired coordination 3.42874655624383e-08 1.40326141606197e-06 0.909842612497961 0.494219653179191 12.1 12 1 postnatal lethality 0.000115560636628468 0.00187880446806088 0.909393877326575 0.493975903614458 12.1 12 1 no abnormal phenotype detected 1.017429639065e-35 6.32714056793547e-33 0.909342741099551 0.493948126801153 12.1 12 1 hunched posture 0.00663388253129251 0.0538947928644006 0.908832349770337 0.493670886075949 12.1 12 1 abnormal myocardium layer morphology 0.00663388253129251 0.0538947928644006 0.908832349770337 0.493670886075949 12.1 12 1 abnormal neurocranium morphology 0.0081639789088378 0.0647779825701245 0.908210925941434 0.493333333333333 12.1 12 1 abnormal skeletal muscle fiber morphology 0.0100583261213104 0.0768666243525641 0.907519482526176 0.492957746478873 12.1 12 1 maternal effect 0.0124077956734902 0.0899836493813615 0.906745478703126 0.492537313432836 12.1 12 1 skin lesions 0.0153275824660087 0.103031026180595 0.905873188680324 0.492063492063492 12.1 12 1 abnormal thoracic vertebrae morphology 0.0189644363057111 0.124142198185412 0.90488262204426 0.491525423728814 12.1 12 1 increased sensitivity to xenobiotic induced morbidity/mortality 0.00186582723851801 0.0193788945962988 0.903747972988405 0.490909090909091 12.1 12 1 abnormal learning/memory/conditioning 0.02350639163579 0.143314091161832 0.903747972988405 0.490909090909091 12.1 12 1 abnormal cervical vertebrae morphology 0.0291960461295666 0.164310327482572 0.902435339766926 0.490196078431373 12.1 12 1 increased circulating LDL cholesterol level 0.0325663858377762 0.181025440830097 0.901698657856912 0.489795918367347 12.1 12 1 abnormal respiratory system physiology 0.0325663858377762 0.181025440830097 0.901698657856912 0.489795918367347 12.1 12 1 thin ventricular wall 0.00514711708323612 0.0452969334204715 0.900028845527547 0.488888888888889 12.1 12 1 abnormal metabolism 0.0405989978990193 0.217416592623919 0.900028845527547 0.488888888888889 12.1 12 1 abnormal intestinal mucosa morphology 0.0453799493513372 0.226671935765967 0.899077440828258 0.488372093023256 12.1 12 1 lethality at weaning, incomplete penetrance 0.0507653784595918 0.247363132063143 0.898033216158307 0.48780487804878 12.1 12 1 acanthosis 0.0568407032362611 0.253090695443525 0.896881891522206 0.487179487179487 12.1 12 1 abnormal circulating hormone level 0.0568407032362611 0.253090695443525 0.896881891522206 0.487179487179487 12.1 12 1 malocclusion 0.0637056054812539 0.278502097776132 0.895606099357879 0.486486486486487 12.1 12 1 abnormal artery morphology 0.0714770164724337 0.308678955686074 0.894184502374771 0.485714285714286 12.1 12 1 abnormal tooth development 0.0802929148030139 0.339097836286073 0.892590590605832 0.484848484848485 12.1 12 1 abnormal aorta morphology 0.0802929148030139 0.339097836286073 0.892590590605832 0.484848484848485 12.1 12 1 cardiovascular system phenotype 0.0802929148030139 0.339097836286073 0.892590590605832 0.484848484848485 12.1 12 1 decreased eosinophil cell number 0.0198778104948825 0.129270728381752 0.891718920107194 0.484375 12.1 12 1 abnormal retinal photoreceptor layer morphology 0.0903172231555837 0.375318178155789 0.890791012802191 0.483870967741935 12.1 12 1 perinatal lethality, complete penetrance 5.12082269004623e-05 0.000933190215493772 0.890233397144725 0.483568075117371 12.1 12 1 focal hair loss 0.101746219249399 0.409868373089684 0.888743217370462 0.482758620689655 12.1 12 1 thin epidermis 0.11481707585108 0.417444052508226 0.886392044837736 0.481481481481481 12.1 12 1 abnormal snout morphology 0.0378274921488685 0.205449534323822 0.885080814002177 0.480769230769231 12.1 12 1 decreased body temperature 0.0378274921488685 0.205449534323822 0.885080814002177 0.480769230769231 12.1 12 1 impaired balance 0.00507344121363999 0.04475242914514 0.884386632971587 0.480392156862745 12.1 12 1 impaired glucose tolerance 2.20603674379362e-05 0.000455395551882707 0.883367754362173 0.479838709677419 12.1 12 1 curly tail 0.047072522982796 0.234890473259188 0.88213054462217 0.479166666666667 12.1 12 1 decreased liver weight 0.0185620638772212 0.122637805828918 0.881590354454 0.47887323943662 12.1 12 1 abnormal cardiovascular development 0.147111675790008 0.46825373452034 0.880463001059557 0.478260869565217 12.1 12 1 abnormal Wolffian duct morphology 0.147111675790008 0.46825373452034 0.880463001059557 0.478260869565217 12.1 12 1 decreased epididymis weight 0.147111675790008 0.46825373452034 0.880463001059557 0.478260869565217 12.1 12 1 abnormal chondrocyte physiology 0.147111675790008 0.46825373452034 0.880463001059557 0.478260869565217 12.1 12 1 decreased insulin secretion 0.00931954172706962 0.0714402466751485 0.87957364449283 0.477777777777778 12.1 12 1 increased susceptibility to parasitic infection 0.00931954172706962 0.0714402466751485 0.87957364449283 0.477777777777778 12.1 12 1 cochlear hair cell degeneration 0.0587319329409713 0.260652423176924 0.878643862627616 0.477272727272727 12.1 12 1 microphthalmia 0.000945565475686764 0.0112004481941468 0.878370397373141 0.477124183006536 12.1 12 1 spina bifida 0.0656777368945414 0.28687159003542 0.876651472916442 0.476190476190476 12.1 12 1 abnormal associative learning 0.167143628922276 0.520688512140464 0.876651472916442 0.476190476190476 12.1 12 1 abnormal clavicle morphology 0.167143628922276 0.520688512140464 0.876651472916442 0.476190476190476 12.1 12 1 increased circulating triglyceride level 0.0013980936054616 0.0159165118699575 0.876046885693741 0.475862068965517 12.1 12 1 abnormal pulmonary alveolus morphology 0.00709207281015997 0.0567251804349612 0.874915529405717 0.475247524752475 12.1 12 1 abnormal retinal pigment epithelium morphology 0.01554371132577 0.104218280115506 0.874459844234151 0.475 12.1 12 1 increased hemoglobin content 0.0349507269297141 0.19255799166703 0.873679773008251 0.474576271186441 12.1 12 1 abnormal heart ventricle morphology 0.0172287870367713 0.114743260385458 0.873279736482148 0.474358974358974 12.1 12 1 abnormal axial skeleton morphology 0.0191008873237517 0.124871109639507 0.872037517795829 0.473684210526316 12.1 12 1 increased grooming behavior 0.082344857435568 0.347174293001653 0.872037517795829 0.473684210526316 12.1 12 1 shiny skin 0.190490683265113 0.573662923271147 0.872037517795829 0.473684210526316 12.1 12 1 altered susceptibility to infection 0.190490683265113 0.573662923271147 0.872037517795829 0.473684210526316 12.1 12 1 delayed sexual maturation 0.190490683265113 0.573662923271147 0.872037517795829 0.473684210526316 12.1 12 1 decreased germ cell number 0.190490683265113 0.573662923271147 0.872037517795829 0.473684210526316 12.1 12 1 abnormal metatarsal bone morphology 0.190490683265113 0.573662923271147 0.872037517795829 0.473684210526316 12.1 12 1 abnormal response to novelty 0.190490683265113 0.573662923271147 0.872037517795829 0.473684210526316 12.1 12 1 abnormal optic vesicle formation 0.190490683265113 0.573662923271147 0.872037517795829 0.473684210526316 12.1 12 1 abnormal photoreceptor inner segment morphology 0.190490683265113 0.573662923271147 0.872037517795829 0.473684210526316 12.1 12 1 decreased fertilization frequency 0.190490683265113 0.573662923271147 0.872037517795829 0.473684210526316 12.1 12 1 increased liver cholesterol level 0.190490683265113 0.573662923271147 0.872037517795829 0.473684210526316 12.1 12 1 postnatal lethality, incomplete penetrance 1.26258190987955e-09 6.90257692489092e-08 0.871866931426934 0.473591549295775 12.1 12 1 kidney cysts 0.0211814587883097 0.13614697347783 0.870728152153493 0.472972972972973 12.1 12 1 abnormal joint morphology 0.043293527574692 0.219843159231403 0.870275825840686 0.472727272727273 12.1 12 1 abnormal locomotor activation 0.0117429122028031 0.0862939264533905 0.869908000047854 0.472527472527473 12.1 12 1 cochlear outer hair cell degeneration 0.0234945218409106 0.143314091161832 0.869346043975472 0.472222222222222 12.1 12 1 heart right ventricle hypertrophy 0.0923386748746126 0.381548926496012 0.869346043975472 0.472222222222222 12.1 12 1 abnormal epidermis stratum granulosum morphology 0.0923386748746126 0.381548926496012 0.869346043975472 0.472222222222222 12.1 12 1 narrow eye opening 0.0923386748746126 0.381548926496012 0.869346043975472 0.472222222222222 12.1 12 1 abnormal retinal blood vessel morphology 0.0923386748746126 0.381548926496012 0.869346043975472 0.472222222222222 12.1 12 1 hyperactivity 1.23330598045137e-06 3.46649562302009e-05 0.868381176002136 0.471698113207547 12.1 12 1 abnormal retina morphology 0.000233007553166263 0.00342275676429663 0.867884958187278 0.471428571428571 12.1 12 1 thick epidermis 0.0260669995801708 0.151322430468319 0.867884958187278 0.471428571428571 12.1 12 1 increased or absent threshold for auditory brainstem response 2.04770294782178e-05 0.000426247789347838 0.866337926176249 0.470588235294118 12.1 12 1 small lung 0.0537301546310188 0.252164289222625 0.866337926176249 0.470588235294118 12.1 12 1 abnormal vision 0.103660626152547 0.414226196874635 0.866337926176249 0.470588235294118 12.1 12 1 abnormal adipose tissue morphology 0.217905177999311 0.636051084497804 0.866337926176249 0.470588235294118 12.1 12 1 distended urinary bladder 0.217905177999311 0.636051084497804 0.866337926176249 0.470588235294118 12.1 12 1 abnormal involuntary movement 0.217905177999311 0.636051084497804 0.866337926176249 0.470588235294118 12.1 12 1 abnormal tarsal bone morphology 0.217905177999311 0.636051084497804 0.866337926176249 0.470588235294118 12.1 12 1 coloboma 0.217905177999311 0.636051084497804 0.866337926176249 0.470588235294118 12.1 12 1 increased circulating magnesium level 0.217905177999311 0.636051084497804 0.866337926176249 0.470588235294118 12.1 12 1 abnormal circulating chemokine level 0.217905177999311 0.636051084497804 0.866337926176249 0.470588235294118 12.1 12 1 delayed heart development 0.217905177999311 0.636051084497804 0.866337926176249 0.470588235294118 12.1 12 1 abnormal cranium morphology 0.00313731729680103 0.0299580682372075 0.865529775125711 0.470149253731343 12.1 12 1 decreased startle reflex 0.00552923509261781 0.0470221274970489 0.865412351468796 0.47008547008547 12.1 12 1 decreased litter size 2.98126285659937e-05 0.000588562806015154 0.864796399617217 0.469750889679715 12.1 12 1 abnormal motor capabilities/coordination/movement 0.00345893327380963 0.0321048377559756 0.8646971346494 0.46969696969697 12.1 12 1 increased bone mineral density 0.0067354372457735 0.0545745933187674 0.863462910934514 0.469026548672566 12.1 12 1 abnormal vertebral body morphology 0.116514238969328 0.417444052508226 0.862953793652123 0.46875 12.1 12 1 polydipsia 0.116514238969328 0.417444052508226 0.862953793652123 0.46875 12.1 12 1 decreased susceptibility to parasitic infection 0.116514238969328 0.417444052508226 0.862953793652123 0.46875 12.1 12 1 cleft secondary palate 0.0132609459896282 0.0945174875335246 0.861729745717865 0.468085106382979 12.1 12 1 infertility 0.00906006203709842 0.0714386553960273 0.860265464076883 0.467289719626168 12.1 12 1 abnormal eating behavior 0.0440180433421119 0.221201783461623 0.859118443458114 0.466666666666667 12.1 12 1 abnormal heart tube morphology 0.13114143812076 0.425034954169888 0.859118443458114 0.466666666666667 12.1 12 1 disorganized myocardium 0.13114143812076 0.425034954169888 0.859118443458114 0.466666666666667 12.1 12 1 abnormal seizure response to electrical stimulation 0.250398368222088 0.698891468277585 0.859118443458114 0.466666666666667 12.1 12 1 abnormal zygomatic bone morphology 0.250398368222088 0.698891468277585 0.859118443458114 0.466666666666667 12.1 12 1 abnormal energy homeostasis 0.250398368222088 0.698891468277585 0.859118443458114 0.466666666666667 12.1 12 1 abnormal cerebral aqueduct morphology 0.250398368222088 0.698891468277585 0.859118443458114 0.466666666666667 12.1 12 1 increased circulating corticosterone level 0.074598251102679 0.321043511449678 0.859118443458113 0.466666666666667 12.1 12 1 albuminuria 0.074598251102679 0.321043511449678 0.859118443458113 0.466666666666667 12.1 12 1 cardiomyopathy 0.074598251102679 0.321043511449678 0.859118443458113 0.466666666666667 12.1 12 1 glomerulosclerosis 0.0489295375723526 0.241732323160332 0.85700238817866 0.46551724137931 12.1 12 1 abnormal enzyme/coenzyme level 0.0489295375723526 0.241732323160332 0.85700238817866 0.46551724137931 12.1 12 1 kidney failure 0.0833279869321097 0.350724818094116 0.856264229360246 0.465116279069767 12.1 12 1 decreased exploration in new environment 0.0219284947915856 0.139965080134917 0.854735186093531 0.464285714285714 12.1 12 1 hypoxia 0.147831972557513 0.46994508848155 0.854735186093531 0.464285714285714 12.1 12 1 prolonged QRS complex duration 0.147831972557513 0.46994508848155 0.854735186093531 0.464285714285714 12.1 12 1 hyperkeratosis 0.0361246739422891 0.197106421191801 0.853782304057752 0.463768115942029 12.1 12 1 abnormal coat appearance 0.0361246739422891 0.197106421191801 0.853782304057752 0.463768115942029 12.1 12 1 decreased anxiety-related response 0.0069532562207113 0.0562478856878678 0.853131555350392 0.463414634146341 12.1 12 1 short snout 0.0111904713058124 0.0846088066054969 0.852300043113208 0.462962962962963 12.1 12 1 abnormal maxilla morphology 0.0605271574420498 0.268107269068917 0.852300043113208 0.462962962962963 12.1 12 1 abnormal gait 3.63183415434717e-05 0.000700324609220046 0.851969052805203 0.462783171521036 12.1 12 1 abnormal cornea morphology 0.0296992255604284 0.166389242300823 0.84967758144209 0.461538461538462 12.1 12 1 absent gastric milk in neonates 0.0296992255604284 0.166389242300823 0.84967758144209 0.461538461538462 12.1 12 1 decreased monocyte cell number 0.0444319745053363 0.222766090451221 0.84967758144209 0.461538461538462 12.1 12 1 abnormal heart looping 0.104205561034975 0.416069555496789 0.84967758144209 0.461538461538462 12.1 12 1 abnormal nasal bone morphology 0.166935906416087 0.520688512140464 0.84967758144209 0.461538461538462 12.1 12 1 abnormal Schwann cell morphology 0.166935906416087 0.520688512140464 0.84967758144209 0.461538461538462 12.1 12 1 abnormal bile duct development 0.289377568321577 0.711722627184227 0.84967758144209 0.461538461538462 12.1 12 1 tracheoesophageal fistula 0.289377568321577 0.711722627184227 0.84967758144209 0.461538461538462 12.1 12 1 increased circulating ammonia level 0.289377568321577 0.711722627184227 0.84967758144209 0.461538461538462 12.1 12 1 small pituitary gland 0.289377568321577 0.711722627184227 0.84967758144209 0.461538461538462 12.1 12 1 increased thermal nociceptive threshold 0.0200393621806861 0.130151209985527 0.84967758144209 0.461538461538462 12.1 12 1 abnormal lens morphology 0.00702841058613049 0.0566715440291721 0.848571230424588 0.4609375 12.1 12 1 increased circulating cholesterol level 0.00193231037810842 0.0197397210083971 0.84726372467663 0.460227272727273 12.1 12 1 decreased respiratory quotient 0.0749998460027603 0.322061840596494 0.846845322837283 0.46 12.1 12 1 increased brown adipose tissue amount 0.116676783858967 0.417444052508226 0.845850204949108 0.459459459459459 12.1 12 1 increased white adipose tissue amount 0.116676783858967 0.417444052508226 0.845850204949108 0.459459459459459 12.1 12 1 abnormal long bone metaphysis morphology 0.116676783858967 0.417444052508226 0.845850204949108 0.459459459459459 12.1 12 1 decreased circulating chloride level 0.116676783858967 0.417444052508226 0.845850204949108 0.459459459459459 12.1 12 1 decreased width of hypertrophic chondrocyte zone 0.116676783858967 0.417444052508226 0.845850204949108 0.459459459459459 12.1 12 1 abnormal maternal nurturing 0.0547044608070809 0.252164289222625 0.845034534548964 0.459016393442623 12.1 12 1 hypoactivity 1.10132332175395e-05 0.000252492328374465 0.844794376951044 0.458885941644562 12.1 12 1 cardiac fibrosis 0.0270227645165465 0.152597336515118 0.844679478021843 0.458823529411765 12.1 12 1 abnormal heart left ventricle morphology 0.0402759161221685 0.216079703437696 0.843777042682076 0.458333333333333 12.1 12 1 abnormal kidney physiology 0.0835444383611769 0.351338614409852 0.843777042682076 0.458333333333333 12.1 12 1 abnormal body weight 0.188880466535062 0.572579797847398 0.843777042682076 0.458333333333333 12.1 12 1 decreased metastatic potential 0.188880466535062 0.572579797847398 0.843777042682076 0.458333333333333 12.1 12 1 abnormal nursing 0.188880466535062 0.572579797847398 0.843777042682076 0.458333333333333 12.1 12 1 abnormal startle reflex 0.188880466535062 0.572579797847398 0.843777042682076 0.458333333333333 12.1 12 1 abnormal primitive streak formation 0.188880466535062 0.572579797847398 0.843777042682076 0.458333333333333 12.1 12 1 prolonged QT interval 0.188880466535062 0.572579797847398 0.843777042682076 0.458333333333333 12.1 12 1 hypopigmentation 0.188880466535062 0.572579797847398 0.843777042682076 0.458333333333333 12.1 12 1 increased circulating total protein level 0.188880466535062 0.572579797847398 0.843777042682076 0.458333333333333 12.1 12 1 impaired fertilization 0.044594294457757 0.222971472288785 0.841585413999785 0.457142857142857 12.1 12 1 thick pulmonary interalveolar septum 0.13076261325159 0.42436007888236 0.841585413999785 0.457142857142857 12.1 12 1 abnormal skeleton development 0.0329970684125558 0.182400461502739 0.840936042538365 0.45679012345679 12.1 12 1 abnormal sleep pattern 0.0931092834508383 0.384095095495788 0.84044195555685 0.456521739130435 12.1 12 1 abnormal craniofacial bone morphology 0.0674254538080983 0.293989160994995 0.83973983195154 0.456140350877193 12.1 12 1 abnormal circulating amino acid level 0.0674254538080983 0.293989160994995 0.83973983195154 0.456140350877193 12.1 12 1 abnormal contextual conditioning behavior 0.0748885156648482 0.322014144712722 0.836803678692968 0.454545454545455 12.1 12 1 abnormal suckling behavior 0.029900703317373 0.167329582681587 0.836803678692968 0.454545454545455 12.1 12 1 obese 0.0403059225708908 0.216079703437696 0.836803678692968 0.454545454545455 12.1 12 1 belly spot 0.14669867577459 0.468137211018978 0.836803678692968 0.454545454545455 12.1 12 1 dextrocardia 0.14669867577459 0.468137211018978 0.836803678692968 0.454545454545455 12.1 12 1 abnormal enterocyte morphology 0.214193224680275 0.63299827020411 0.836803678692968 0.454545454545455 12.1 12 1 intestinal ulcer 0.214193224680275 0.63299827020411 0.836803678692968 0.454545454545455 12.1 12 1 prolonged PR interval 0.214193224680275 0.63299827020411 0.836803678692968 0.454545454545455 12.1 12 1 abnormal ear position 0.336890737966616 0.711722627184227 0.836803678692968 0.454545454545455 12.1 12 1 decreased atrioventricular cushion size 0.336890737966616 0.711722627184227 0.836803678692968 0.454545454545455 12.1 12 1 abnormal stomach epithelium morphology 0.336890737966616 0.711722627184227 0.836803678692968 0.454545454545455 12.1 12 1 abnormal large intestine morphology 0.336890737966616 0.711722627184227 0.836803678692968 0.454545454545455 12.1 12 1 abnormal glossopharyngeal ganglion morphology 0.336890737966616 0.711722627184227 0.836803678692968 0.454545454545455 12.1 12 1 abnormal eye distance/ position 0.336890737966616 0.711722627184227 0.836803678692968 0.454545454545455 12.1 12 1 abnormal hemoglobin 0.336890737966616 0.711722627184227 0.836803678692968 0.454545454545455 12.1 12 1 rectal hemorrhage 0.336890737966616 0.711722627184227 0.836803678692968 0.454545454545455 12.1 12 1 pulmonary hypertension 0.336890737966616 0.711722627184227 0.836803678692968 0.454545454545455 12.1 12 1 pathological neovascularization 0.336890737966616 0.711722627184227 0.836803678692968 0.454545454545455 12.1 12 1 abnormal coronal suture morphology 0.336890737966616 0.711722627184227 0.836803678692968 0.454545454545455 12.1 12 1 abnormal spinal cord ventral horn morphology 0.336890737966616 0.711722627184227 0.836803678692968 0.454545454545455 12.1 12 1 cyclopia 0.336890737966616 0.711722627184227 0.836803678692968 0.454545454545455 12.1 12 1 increased circulating triiodothyronine level 0.336890737966616 0.711722627184227 0.836803678692968 0.454545454545455 12.1 12 1 enhanced behavioral response to addictive substance 0.336890737966616 0.711722627184227 0.836803678692968 0.454545454545455 12.1 12 1 abnormal aorta smooth muscle morphology 0.336890737966616 0.711722627184227 0.836803678692968 0.454545454545455 12.1 12 1 palatal shelf hypoplasia 0.336890737966616 0.711722627184227 0.836803678692968 0.454545454545455 12.1 12 1 decreased palatine bone horizontal plate size 0.336890737966616 0.711722627184227 0.836803678692968 0.454545454545455 12.1 12 1 aberrant origin of the right subclavian artery 0.336890737966616 0.711722627184227 0.836803678692968 0.454545454545455 12.1 12 1 common atrioventricular valve 0.336890737966616 0.711722627184227 0.836803678692968 0.454545454545455 12.1 12 1 abnormal dendritic cell chemotaxis 0.336890737966616 0.711722627184227 0.836803678692968 0.454545454545455 12.1 12 1 increased pancreatic beta cell proliferation 0.336890737966616 0.711722627184227 0.836803678692968 0.454545454545455 12.1 12 1 chylous ascites 0.336890737966616 0.711722627184227 0.836803678692968 0.454545454545455 12.1 12 1 hypolactation 0.336890737966616 0.711722627184227 0.836803678692968 0.454545454545455 12.1 12 1 increased circulating glucose level 0.00784244873556026 0.0625259334285454 0.835616723120354 0.453900709219858 12.1 12 1 abnormal myocardial fiber morphology 0.0245721845417181 0.147640843109961 0.835078310283291 0.45360824742268 12.1 12 1 enlarged kidney 0.0832034090623394 0.35049700261231 0.833645928962051 0.452830188679245 12.1 12 1 decreased inflammatory response 0.0364114056117718 0.198191184812434 0.83281889927062 0.452380952380952 12.1 12 1 absent mature ovarian follicles 0.164761379856786 0.514556098422795 0.831404945282045 0.451612903225806 12.1 12 1 abnormal eyelid morphology 0.164761379856786 0.514556098422795 0.831404945282045 0.451612903225806 12.1 12 1 abnormal nose morphology 0.164761379856786 0.514556098422795 0.831404945282045 0.451612903225806 12.1 12 1 abnormal dendritic spine morphology 0.0924713782009766 0.381780171410671 0.830240512585572 0.450980392156863 12.1 12 1 decreased heart rate 0.0269817869213213 0.15253907946997 0.828435641906038 0.45 12.1 12 1 abnormal incisor morphology 0.0743927991784149 0.320992346845285 0.828435641906038 0.45 12.1 12 1 decreased circulating phosphate level 0.129322716823344 0.419961172451788 0.828435641906038 0.45 12.1 12 1 impaired ovarian folliculogenesis 0.129322716823344 0.419961172451788 0.828435641906038 0.45 12.1 12 1 abnormal hyoid bone morphology 0.243534723457185 0.682968009695318 0.828435641906038 0.45 12.1 12 1 enhanced behavioral response to xenobiotic 0.243534723457185 0.682968009695318 0.828435641906038 0.45 12.1 12 1 decreased muscle cell glucose uptake 0.243534723457185 0.682968009695318 0.828435641906038 0.45 12.1 12 1 neonatal lethality, complete penetrance 9.5687843908307e-06 0.000223496255137947 0.827628199759931 0.449561403508772 12.1 12 1 increased startle reflex 0.0362379503726648 0.1974630921183 0.827401390168328 0.449438202247191 12.1 12 1 abnormal epidermal layer morphology 0.0602001569440664 0.266930285915089 0.827101607055948 0.449275362318841 12.1 12 1 abnormal epidermis stratum corneum morphology 0.102806304744444 0.411142577253706 0.826557103035503 0.448979591836735 12.1 12 1 enlarged epididymis 0.185276647120355 0.567231581183856 0.825261558986858 0.448275862068966 12.1 12 1 decreased bone strength 0.185276647120355 0.567231581183856 0.825261558986858 0.448275862068966 12.1 12 1 increased total body fat amount 0.0136721185920049 0.0973087124395198 0.824314071548297 0.447761194029851 12.1 12 1 seizures 0.0220533955398728 0.139965080134917 0.823590989029395 0.447368421052632 12.1 12 1 enhanced long term potentiation 0.0914038744986285 0.378945229692231 0.821860755859165 0.446428571428571 12.1 12 1 respiratory distress 0.00699287694390591 0.0564765629804089 0.81939042295138 0.445086705202312 12.1 12 1 abnormal hair follicle morphology 0.0814020018017232 0.343490211165032 0.81820804138868 0.444444444444444 12.1 12 1 reduced long term depression 0.161501763953171 0.507562397768178 0.81820804138868 0.444444444444444 12.1 12 1 impaired wound healing 0.161501763953171 0.507562397768178 0.81820804138868 0.444444444444444 12.1 12 1 blepharoptosis 0.277745575756234 0.711722627184227 0.81820804138868 0.444444444444444 12.1 12 1 abnormal iron level 0.277745575756234 0.711722627184227 0.81820804138868 0.444444444444444 12.1 12 1 eye inflammation 0.277745575756234 0.711722627184227 0.81820804138868 0.444444444444444 12.1 12 1 abnormal white adipose tissue morphology 0.277745575756234 0.711722627184227 0.81820804138868 0.444444444444444 12.1 12 1 abnormal pregnancy 0.277745575756234 0.711722627184227 0.81820804138868 0.444444444444444 12.1 12 1 abnormal chondrocyte morphology 0.101344410358571 0.408580584711417 0.818208041388679 0.444444444444444 12.1 12 1 irregular heartbeat 0.127205856582362 0.417444052508226 0.818208041388679 0.444444444444444 12.1 12 1 increased circulating insulin level 0.0100891648134246 0.0769840413294284 0.81692959132401 0.44375 12.1 12 1 postnatal lethality, complete penetrance 0.000127085242458117 0.00200713994040995 0.815558403948949 0.44300518134715 12.1 12 1 eyelids open at birth 0.112386499246427 0.417444052508226 0.814274348882003 0.442307692307692 12.1 12 1 increased blood urea nitrogen level 0.0159571255286202 0.106559328194477 0.812565227310137 0.441379310344828 12.1 12 1 abnormal retinal photoreceptor morphology 0.18067608337094 0.55416986114083 0.812191805790233 0.441176470588235 12.1 12 1 abnormal skin physiology 0.18067608337094 0.55416986114083 0.812191805790233 0.441176470588235 12.1 12 1 increased food intake 0.0579901371612825 0.25759011819409 0.810902612447709 0.44047619047619 12.1 12 1 abnormal keratinocyte physiology 0.235285540247771 0.670816610929954 0.810025960974793 0.44 12.1 12 1 increased liver glycogen level 0.235285540247771 0.670816610929954 0.810025960974793 0.44 12.1 12 1 palatal shelves fail to meet at midline 0.15763403257932 0.496347665874759 0.808229894542476 0.439024390243902 12.1 12 1 abnormal tooth morphology 0.0975884345264386 0.394403149463385 0.805423540741982 0.4375 12.1 12 1 failure of tooth eruption 0.317916434357515 0.711722627184227 0.805423540741982 0.4375 12.1 12 1 delayed hair appearance 0.317916434357515 0.711722627184227 0.805423540741982 0.4375 12.1 12 1 disorganized retinal layers 0.317916434357515 0.711722627184227 0.805423540741982 0.4375 12.1 12 1 poor circulation 0.317916434357515 0.711722627184227 0.805423540741982 0.4375 12.1 12 1 abnormal extraembryonic endoderm formation 0.317916434357515 0.711722627184227 0.805423540741982 0.4375 12.1 12 1 abnormal molar crown morphology 0.317916434357515 0.711722627184227 0.805423540741982 0.4375 12.1 12 1 small pancreas 0.317916434357515 0.711722627184227 0.805423540741982 0.4375 12.1 12 1 bowed radius 0.317916434357515 0.711722627184227 0.805423540741982 0.4375 12.1 12 1 increased cochlear outer hair cell number 0.317916434357515 0.711722627184227 0.805423540741982 0.4375 12.1 12 1 increased thymus weight 0.317916434357515 0.711722627184227 0.805423540741982 0.4375 12.1 12 1 decreased circulating triiodothyronine level 0.317916434357515 0.711722627184227 0.805423540741982 0.4375 12.1 12 1 decreased adipocyte glucose uptake 0.317916434357515 0.711722627184227 0.805423540741982 0.4375 12.1 12 1 abnormal lung morphology 0.0336581885715412 0.185848488505458 0.804456645735088 0.436974789915966 12.1 12 1 increased circulating alanine transaminase level 0.0771397247014959 0.329333858336996 0.802473271361974 0.435897435897436 12.1 12 1 increased urine protein level 0.0771397247014959 0.329333858336996 0.802473271361974 0.435897435897436 12.1 12 1 abnormal inner ear morphology 0.153433989760457 0.484041914431371 0.800420910054143 0.434782608695652 12.1 12 1 abnormal pulmonary artery morphology 0.265794416134326 0.711722627184227 0.800420910054143 0.434782608695652 12.1 12 1 abnormal cranial nerve morphology 0.265794416134326 0.711722627184227 0.800420910054143 0.434782608695652 12.1 12 1 abnormal circulating insulin level 0.265794416134326 0.711722627184227 0.800420910054143 0.434782608695652 12.1 12 1 abnormal ulna morphology 0.265794416134326 0.711722627184227 0.800420910054143 0.434782608695652 12.1 12 1 abnormal palatal shelf fusion at midline 0.265794416134326 0.711722627184227 0.800420910054143 0.434782608695652 12.1 12 1 improved glucose tolerance 0.0107402271326497 0.0816738372663844 0.798379019977474 0.433673469387755 12.1 12 1 abnormal response to new environment 0.226674159884751 0.658705575599672 0.797752840353963 0.433333333333333 12.1 12 1 abnormal lactation 0.226674159884751 0.658705575599672 0.797752840353963 0.433333333333333 12.1 12 1 decreased compact bone thickness 0.105117063533263 0.417444052508226 0.79683693583002 0.432835820895522 12.1 12 1 decreased sensitivity to induced morbidity/mortality 0.17026939182525 0.530094007716282 0.794963494758319 0.431818181818182 12.1 12 1 cochlear inner hair cell degeneration 0.149068818856446 0.473574312778302 0.794143098994895 0.431372549019608 12.1 12 1 abnormal digit morphology 0.102470299088606 0.410184167647602 0.792639040095283 0.430555555555556 12.1 12 1 abnormal muscle morphology 0.188980106143805 0.572579797847398 0.788986325624798 0.428571428571429 12.1 12 1 impaired adaptive thermogenesis 0.218111185960453 0.636051084497804 0.788986325624798 0.428571428571429 12.1 12 1 decreased bone mineralization 0.218111185960453 0.636051084497804 0.788986325624798 0.428571428571429 12.1 12 1 abnormal scapula morphology 0.300828044358367 0.711722627184227 0.788986325624798 0.428571428571429 12.1 12 1 abnormal embryonic/fetal subventricular zone morphology 0.300828044358367 0.711722627184227 0.788986325624798 0.428571428571429 12.1 12 1 vascular ring 0.300828044358367 0.711722627184227 0.788986325624798 0.428571428571429 12.1 12 1 abnormal eye development 0.144643282483732 0.462468078635327 0.788986325624798 0.428571428571429 12.1 12 1 abnormal circulating cholesterol level 0.254230219601029 0.701106065695741 0.788986325624798 0.428571428571429 12.1 12 1 abnormal jaw morphology 0.254230219601029 0.701106065695741 0.788986325624798 0.428571428571429 12.1 12 1 reddish skin 0.254230219601029 0.701106065695741 0.788986325624798 0.428571428571429 12.1 12 1 absent corpus callosum 0.254230219601029 0.701106065695741 0.788986325624798 0.428571428571429 12.1 12 1 translucent skin 0.365495315247787 0.723894949422334 0.788986325624798 0.428571428571429 12.1 12 1 extended life span 0.365495315247787 0.723894949422334 0.788986325624798 0.428571428571429 12.1 12 1 abnormal fluid regulation 0.365495315247787 0.723894949422334 0.788986325624798 0.428571428571429 12.1 12 1 increased lactate dehydrogenase level 0.365495315247787 0.723894949422334 0.788986325624798 0.428571428571429 12.1 12 1 absent otoliths 0.365495315247787 0.723894949422334 0.788986325624798 0.428571428571429 12.1 12 1 decreased coping response 0.365495315247787 0.723894949422334 0.788986325624798 0.428571428571429 12.1 12 1 intestinal obstruction 0.365495315247787 0.723894949422334 0.788986325624798 0.428571428571429 12.1 12 1 amyloid beta deposits 0.365495315247787 0.723894949422334 0.788986325624798 0.428571428571429 12.1 12 1 abnormal voluntary movement 0.365495315247787 0.723894949422334 0.788986325624798 0.428571428571429 12.1 12 1 premature hair loss 0.365495315247787 0.723894949422334 0.788986325624798 0.428571428571429 12.1 12 1 sternebra fusion 0.365495315247787 0.723894949422334 0.788986325624798 0.428571428571429 12.1 12 1 abnormal limb morphology 0.109452931476432 0.417444052508226 0.785479719733132 0.426666666666667 12.1 12 1 decreased susceptibility to injury 0.123698174052223 0.417444052508226 0.785118745597226 0.426470588235294 12.1 12 1 abnormal long bone morphology 0.140224497979092 0.451824402490922 0.784674924938324 0.426229508196721 12.1 12 1 abnormal osteoblast physiology 0.159552563054231 0.502070841995445 0.784116039664151 0.425925925925926 12.1 12 1 pulmonary hypoplasia 0.182395198639381 0.559098036494713 0.783390677925331 0.425531914893617 12.1 12 1 short limbs 0.0944143341183324 0.389156016767774 0.782940453397788 0.425287356321839 12.1 12 1 abnormal skin pigmentation 0.209773959952787 0.621205625455426 0.782411439577925 0.425 12.1 12 1 absent vibrissae 0.243246703010936 0.682968009695318 0.781016766780103 0.424242424242424 12.1 12 1 abnormal skeleton physiology 0.243246703010936 0.682968009695318 0.781016766780103 0.424242424242424 12.1 12 1 dilated heart atrium 0.243246703010936 0.682968009695318 0.781016766780103 0.424242424242424 12.1 12 1 decreased sensitivity to xenobiotic induced morbidity/mortality 0.243246703010936 0.682968009695318 0.781016766780103 0.424242424242424 12.1 12 1 respiratory failure 0.0398607038011632 0.214154429169317 0.780277867284568 0.423841059602649 12.1 12 1 abnormal brain wave pattern 0.17596918657046 0.541067183676168 0.778871116321916 0.423076923076923 12.1 12 1 small seminal vesicle 0.285408605057672 0.711722627184227 0.778871116321916 0.423076923076923 12.1 12 1 abnormal kidney morphology 0.0306268160635612 0.171200460580019 0.778466507949801 0.422857142857143 12.1 12 1 atelectasis 0.131566081209928 0.426133628918876 0.777873842165294 0.422535211267606 12.1 12 1 decreased osteoclast cell number 0.2017388983489 0.601864539330457 0.777297639319245 0.422222222222222 12.1 12 1 lethality at weaning, complete penetrance 0.2017388983489 0.601864539330457 0.777297639319245 0.422222222222222 12.1 12 1 cyanosis 0.0262132127395762 0.151340692233937 0.776658414286911 0.421875 12.1 12 1 abnormal lipid level 0.112838673234686 0.417444052508226 0.776311846498295 0.421686746987952 12.1 12 1 abnormal blood homeostasis 0.0750290800505198 0.322061840596494 0.77514446026296 0.421052631578947 12.1 12 1 abnormal frontal bone morphology 0.23287946356738 0.670816610929954 0.775144460262959 0.421052631578947 12.1 12 1 abnormal reproductive system physiology 0.23287946356738 0.670816610929954 0.775144460262959 0.421052631578947 12.1 12 1 thin dermal layer 0.341203679386139 0.711722627184227 0.775144460262959 0.421052631578947 12.1 12 1 abnormal neural crest cell migration 0.341203679386139 0.711722627184227 0.775144460262959 0.421052631578947 12.1 12 1 abnormal digestive system development 0.341203679386139 0.711722627184227 0.775144460262959 0.421052631578947 12.1 12 1 abnormal cochlear inner hair cell morphology 0.341203679386139 0.711722627184227 0.775144460262959 0.421052631578947 12.1 12 1 decreased liver regeneration 0.341203679386139 0.711722627184227 0.775144460262959 0.421052631578947 12.1 12 1 decreased liver glycogen level 0.341203679386139 0.711722627184227 0.775144460262959 0.421052631578947 12.1 12 1 thin interventricular septum 0.341203679386139 0.711722627184227 0.775144460262959 0.421052631578947 12.1 12 1 right-sided stomach 0.341203679386139 0.711722627184227 0.775144460262959 0.421052631578947 12.1 12 1 increased circulating chloride level 0.194035072092569 0.583277633631741 0.773206599112302 0.42 12.1 12 1 abnormal circulating protein level 0.194035072092569 0.583277633631741 0.773206599112302 0.42 12.1 12 1 abnormal postnatal growth/weight/body size 0.271388945460504 0.711722627184227 0.772018877761899 0.419354838709677 12.1 12 1 decreased susceptibility to bacterial infection induced morbidity/mortality 0.271388945460504 0.711722627184227 0.772018877761899 0.419354838709677 12.1 12 1 abnormal intestine morphology 0.139331819430744 0.449239015987008 0.771216363335951 0.418918918918919 12.1 12 1 increased circulating creatinine level 0.119318195183982 0.417444052508226 0.770637806424221 0.418604651162791 12.1 12 1 abnormal long bone epiphyseal plate morphology 0.179632495234475 0.551649175179947 0.767070038801887 0.416666666666667 12.1 12 1 abnormal eye physiology 0.179632495234475 0.551649175179947 0.767070038801887 0.416666666666667 12.1 12 1 abnormal foregut morphology 0.320732951562371 0.711722627184227 0.767070038801887 0.416666666666667 12.1 12 1 abnormal adrenal gland morphology 0.320732951562371 0.711722627184227 0.767070038801887 0.416666666666667 12.1 12 1 abnormal limb bone morphology 0.258546487394226 0.711722627184227 0.767070038801887 0.416666666666667 12.1 12 1 abnormal cardiac muscle contractility 0.320732951562371 0.711722627184227 0.767070038801887 0.416666666666667 12.1 12 1 abnormal impulse conducting system conduction 0.320732951562371 0.711722627184227 0.767070038801887 0.416666666666667 12.1 12 1 abnormal lung saccule morphology 0.320732951562371 0.711722627184227 0.767070038801887 0.416666666666667 12.1 12 1 abnormal adipose tissue distribution 0.422458044502992 0.81147829011675 0.767070038801887 0.416666666666667 12.1 12 1 amyloidosis 0.422458044502992 0.81147829011675 0.767070038801887 0.416666666666667 12.1 12 1 abnormal superior cervical ganglion morphology 0.422458044502992 0.81147829011675 0.767070038801887 0.416666666666667 12.1 12 1 abnormal glossopharyngeal nerve morphology 0.422458044502992 0.81147829011675 0.767070038801887 0.416666666666667 12.1 12 1 increased circulating parathyroid hormone level 0.422458044502992 0.81147829011675 0.767070038801887 0.416666666666667 12.1 12 1 decreased synaptic depression 0.422458044502992 0.81147829011675 0.767070038801887 0.416666666666667 12.1 12 1 abnormal alisphenoid bone morphology 0.422458044502992 0.81147829011675 0.767070038801887 0.416666666666667 12.1 12 1 dilated bile duct 0.422458044502992 0.81147829011675 0.767070038801887 0.416666666666667 12.1 12 1 increased fear-related response 0.422458044502992 0.81147829011675 0.767070038801887 0.416666666666667 12.1 12 1 absent ovary 0.422458044502992 0.81147829011675 0.767070038801887 0.416666666666667 12.1 12 1 abnormal nucleotide metabolism 0.422458044502992 0.81147829011675 0.767070038801887 0.416666666666667 12.1 12 1 vestibular saccular macula degeneration 0.422458044502992 0.81147829011675 0.767070038801887 0.416666666666667 12.1 12 1 stria vascularis degeneration 0.422458044502992 0.81147829011675 0.767070038801887 0.416666666666667 12.1 12 1 abnormal anogenital distance 0.422458044502992 0.81147829011675 0.767070038801887 0.416666666666667 12.1 12 1 abnormal palatine bone morphology 0.422458044502992 0.81147829011675 0.767070038801887 0.416666666666667 12.1 12 1 abnormal fatty acid level 0.422458044502992 0.81147829011675 0.767070038801887 0.416666666666667 12.1 12 1 hemoperitoneum 0.422458044502992 0.81147829011675 0.767070038801887 0.416666666666667 12.1 12 1 decreased keratinocyte proliferation 0.422458044502992 0.81147829011675 0.767070038801887 0.416666666666667 12.1 12 1 impaired behavioral response to cocaine 0.422458044502992 0.81147829011675 0.767070038801887 0.416666666666667 12.1 12 1 decreased oligodendrocyte number 0.422458044502992 0.81147829011675 0.767070038801887 0.416666666666667 12.1 12 1 abnormal aorta elastic tissue morphology 0.422458044502992 0.81147829011675 0.767070038801887 0.416666666666667 12.1 12 1 abnormal respiratory motile cilium morphology 0.422458044502992 0.81147829011675 0.767070038801887 0.416666666666667 12.1 12 1 abnormal parietal bone morphology 0.302903329587387 0.711722627184227 0.761779900603253 0.413793103448276 12.1 12 1 decreased retinal photoreceptor cell number 0.302903329587387 0.711722627184227 0.761779900603253 0.413793103448276 12.1 12 1 increased retinal apoptosis 0.302903329587387 0.711722627184227 0.761779900603253 0.413793103448276 12.1 12 1 increased sensitivity to induced morbidity/mortality 0.0494957595114905 0.242125273913142 0.760399864551436 0.41304347826087 12.1 12 1 abnormal renal glomerulus morphology 0.109797065465017 0.417444052508226 0.760032698996365 0.412844036697248 12.1 12 1 abnormal social investigation 0.15453519796619 0.487206977111405 0.759399338413868 0.4125 12.1 12 1 distended abdomen 0.225511449357855 0.656093251786743 0.758045685404218 0.411764705882353 12.1 12 1 abnormal cued conditioning behavior 0.225511449357855 0.656093251786743 0.758045685404218 0.411764705882353 12.1 12 1 abnormal response to novel object 0.225511449357855 0.656093251786743 0.758045685404218 0.411764705882353 12.1 12 1 decreased osteoblast cell number 0.287046136758933 0.711722627184227 0.758045685404218 0.411764705882353 12.1 12 1 abnormal bone marrow cavity morphology 0.387924313808258 0.765235313717717 0.758045685404218 0.411764705882353 12.1 12 1 increased incidence of corneal inflammation 0.387924313808258 0.765235313717717 0.758045685404218 0.411764705882353 12.1 12 1 abnormal cranial suture morphology 0.387924313808258 0.765235313717717 0.758045685404218 0.411764705882353 12.1 12 1 absence seizures 0.387924313808258 0.765235313717717 0.758045685404218 0.411764705882353 12.1 12 1 abnormal duodenum morphology 0.387924313808258 0.765235313717717 0.758045685404218 0.411764705882353 12.1 12 1 common atrium 0.387924313808258 0.765235313717717 0.758045685404218 0.411764705882353 12.1 12 1 increased body weight 0.0389290068500471 0.211201536618304 0.756111895390432 0.410714285714286 12.1 12 1 reduced long term potentiation 0.114958669948771 0.417444052508226 0.756111895390432 0.410714285714286 12.1 12 1 increased vascular permeability 0.272738442311453 0.711722627184227 0.755268961281858 0.41025641025641 12.1 12 1 abnormal tail morphology 0.198573092214757 0.596558655657257 0.753123310823671 0.409090909090909 12.1 12 1 renal interstitial fibrosis 0.259692094250919 0.711722627184227 0.753123310823671 0.409090909090909 12.1 12 1 abnormal photoreceptor outer segment morphology 0.259692094250919 0.711722627184227 0.753123310823671 0.409090909090909 12.1 12 1 abnormal amino acid level 0.259692094250919 0.711722627184227 0.753123310823671 0.409090909090909 12.1 12 1 abnormal basisphenoid bone morphology 0.360805996443201 0.718291249421738 0.753123310823671 0.409090909090909 12.1 12 1 abnormal retinal outer plexiform layer morphology 0.360805996443201 0.718291249421738 0.753123310823671 0.409090909090909 12.1 12 1 abnormal limb posture 0.360805996443201 0.718291249421738 0.753123310823671 0.409090909090909 12.1 12 1 abnormal blood-brain barrier function 0.360805996443201 0.718291249421738 0.753123310823671 0.409090909090909 12.1 12 1 corneal opacity 0.190628941719927 0.573731993379696 0.751944714093117 0.408450704225352 12.1 12 1 cardiac hypertrophy 0.144776141208714 0.462595570014999 0.751415548214093 0.408163265306122 12.1 12 1 organ of Corti degeneration 0.247699905755062 0.693866571583015 0.751415548214093 0.408163265306122 12.1 12 1 abnormal long bone hypertrophic chondrocyte zone 0.247699905755062 0.693866571583015 0.751415548214093 0.408163265306122 12.1 12 1 abnormal heart valve morphology 0.338193228563007 0.711722627184227 0.750024037939623 0.407407407407407 12.1 12 1 abnormal trigeminal ganglion morphology 0.338193228563007 0.711722627184227 0.750024037939623 0.407407407407407 12.1 12 1 abnormal type II pneumocyte morphology 0.338193228563007 0.711722627184227 0.750024037939623 0.407407407407407 12.1 12 1 abnormal palate morphology 0.338193228563007 0.711722627184227 0.750024037939623 0.407407407407407 12.1 12 1 kidney cortex cysts 0.318669269173231 0.711722627184227 0.74789328783184 0.40625 12.1 12 1 abnormal lumbar vertebrae morphology 0.318669269173231 0.711722627184227 0.74789328783184 0.40625 12.1 12 1 abnormal depression-related behavior 0.318669269173231 0.711722627184227 0.74789328783184 0.40625 12.1 12 1 abnormal pancreatic beta cell physiology 0.301427640340812 0.711722627184227 0.746338416131566 0.405405405405405 12.1 12 1 abnormal hair growth 0.259072337052542 0.711722627184227 0.743467883761829 0.403846153846154 12.1 12 1 abnormal trabecular bone morphology 0.140519702492284 0.45248253715153 0.742575365293928 0.403361344537815 12.1 12 1 increased body length 0.283476461530058 0.711722627184227 0.736387237249812 0.4 12.1 12 1 perinatal lethality 0.314714763883897 0.711722627184227 0.736387237249812 0.4 12.1 12 1 enhanced paired-pulse facilitation 0.353722776055811 0.711722627184227 0.736387237249812 0.4 12.1 12 1 waved hair 0.40631631667211 0.789310298884711 0.736387237249812 0.4 12.1 12 1 increased urine glucose level 0.40631631667211 0.789310298884711 0.736387237249812 0.4 12.1 12 1 abnormal hearing physiology 0.40631631667211 0.789310298884711 0.736387237249812 0.4 12.1 12 1 absent placental labyrinth 0.40631631667211 0.789310298884711 0.736387237249812 0.4 12.1 12 1 abnormal postnatal subventricular zone morphology 0.40631631667211 0.789310298884711 0.736387237249812 0.4 12.1 12 1 abnormal neuron proliferation 0.40631631667211 0.789310298884711 0.736387237249812 0.4 12.1 12 1 abnormal circulating cytokine level 0.40631631667211 0.789310298884711 0.736387237249812 0.4 12.1 12 1 nuclear cataracts 0.40631631667211 0.789310298884711 0.736387237249812 0.4 12.1 12 1 hyperpigmentation 0.442226613264919 0.811537219104749 0.736387237249812 0.4 12.1 12 1 abnormal pup retrieval 0.442226613264919 0.811537219104749 0.736387237249812 0.4 12.1 12 1 no suckling reflex 0.442226613264919 0.811537219104749 0.736387237249812 0.4 12.1 12 1 abnormal respiratory system morphology 0.442226613264919 0.811537219104749 0.736387237249812 0.4 12.1 12 1 abnormal cricoid cartilage morphology 0.442226613264919 0.811537219104749 0.736387237249812 0.4 12.1 12 1 abnormal glial cell morphology 0.442226613264919 0.811537219104749 0.736387237249812 0.4 12.1 12 1 abnormal pericyte morphology 0.442226613264919 0.811537219104749 0.736387237249812 0.4 12.1 12 1 abnormal olfactory nerve morphology 0.442226613264919 0.811537219104749 0.736387237249812 0.4 12.1 12 1 ostium primum atrial septal defect 0.442226613264919 0.811537219104749 0.736387237249812 0.4 12.1 12 1 abnormal coronary vessel morphology 0.442226613264919 0.811537219104749 0.736387237249812 0.4 12.1 12 1 decreased trabecular bone mass 0.442226613264919 0.811537219104749 0.736387237249812 0.4 12.1 12 1 herniated liver 0.442226613264919 0.811537219104749 0.736387237249812 0.4 12.1 12 1 abnormal branching involved in lung morphogenesis 0.442226613264919 0.811537219104749 0.736387237249812 0.4 12.1 12 1 altered response to myocardial infarction 0.298327558185598 0.711722627184227 0.736387237249811 0.4 12.1 12 1 short femur 0.214265143120346 0.63299827020411 0.732203218856347 0.397727272727273 12.1 12 1 abnormal pancreatic islet morphology 0.294416691854292 0.711722627184227 0.729440187841794 0.39622641509434 12.1 12 1 abnormal cardiovascular system morphology 0.309937656588437 0.711722627184227 0.728716536861793 0.395833333333333 12.1 12 1 abnormal organ of Corti morphology 0.327054665133339 0.711722627184227 0.727824594956209 0.395348837209302 12.1 12 1 delayed endochondral bone ossification 0.327054665133339 0.711722627184227 0.727824594956209 0.395348837209302 12.1 12 1 decreased threshold for auditory brainstem response 0.346132973019138 0.711722627184227 0.726697931496525 0.394736842105263 12.1 12 1 deafness 0.219518019003374 0.639778643551134 0.725229854867239 0.393939393939394 12.1 12 1 abnormal seminal vesicle morphology 0.304801754504004 0.711722627184227 0.723237465156065 0.392857142857143 12.1 12 1 abnormal retinal inner nuclear layer morphology 0.392522234361934 0.772176231957665 0.723237465156065 0.392857142857143 12.1 12 1 enhanced coordination 0.392522234361934 0.772176231957665 0.723237465156065 0.392857142857143 12.1 12 1 abnormal spatial learning 0.156975866716816 0.49458830710333 0.722834097913925 0.392638036809816 12.1 12 1 abnormal gluconeogenesis 0.32087324357664 0.711722627184227 0.721948271813541 0.392156862745098 12.1 12 1 abnormal forelimb morphology 0.338568047528703 0.711722627184227 0.720378819048729 0.391304347826087 12.1 12 1 bidirectional circling 0.421884869498906 0.81147829011675 0.720378819048729 0.391304347826087 12.1 12 1 abnormal cochlear ganglion morphology 0.421884869498906 0.81147829011675 0.720378819048729 0.391304347826087 12.1 12 1 abnormal lens development 0.421884869498906 0.81147829011675 0.720378819048729 0.391304347826087 12.1 12 1 renal hypoplasia 0.38038404177118 0.752150480052313 0.715932036215095 0.388888888888889 12.1 12 1 abnormal mammary gland morphology 0.458038056205001 0.836541604118899 0.715932036215095 0.388888888888889 12.1 12 1 absent spleen 0.458038056205001 0.836541604118899 0.715932036215095 0.388888888888889 12.1 12 1 abnormal phrenic nerve morphology 0.458038056205001 0.836541604118899 0.715932036215095 0.388888888888889 12.1 12 1 abnormal thyroid cartilage morphology 0.458038056205001 0.836541604118899 0.715932036215095 0.388888888888889 12.1 12 1 abnormal metacarpal bone morphology 0.458038056205001 0.836541604118899 0.715932036215095 0.388888888888889 12.1 12 1 decreased heart rate variability 0.458038056205001 0.836541604118899 0.715932036215095 0.388888888888889 12.1 12 1 decreased pulmonary respiratory rate 0.458038056205001 0.836541604118899 0.715932036215095 0.388888888888889 12.1 12 1 atrioventricular block 0.458038056205001 0.836541604118899 0.715932036215095 0.388888888888889 12.1 12 1 circling 0.27632119324092 0.711722627184227 0.714728789095405 0.388235294117647 12.1 12 1 small kidney 0.283865461479393 0.711722627184227 0.711283126889023 0.386363636363636 12.1 12 1 hypertension 0.369468135688937 0.73114716589199 0.711283126889023 0.386363636363636 12.1 12 1 abnormal circadian rhythm 0.369468135688937 0.73114716589199 0.711283126889023 0.386363636363636 12.1 12 1 abnormal response to injury 0.392004554711441 0.772176231957665 0.708064651201742 0.384615384615385 12.1 12 1 abnormal xiphoid process morphology 0.43537869705196 0.811537219104749 0.708064651201742 0.384615384615385 12.1 12 1 abnormal ocular fundus morphology 0.43537869705196 0.811537219104749 0.708064651201742 0.384615384615385 12.1 12 1 absent teeth 0.505633342116376 0.889083153442132 0.708064651201742 0.384615384615385 12.1 12 1 short hair 0.505633342116376 0.889083153442132 0.708064651201742 0.384615384615385 12.1 12 1 abnormal lung interstitium morphology 0.505633342116376 0.889083153442132 0.708064651201742 0.384615384615385 12.1 12 1 dystrophic cardiac calcinosis 0.505633342116376 0.889083153442132 0.708064651201742 0.384615384615385 12.1 12 1 abnormal soleus morphology 0.505633342116376 0.889083153442132 0.708064651201742 0.384615384615385 12.1 12 1 abnormal vestibulocochlear ganglion morphology 0.505633342116376 0.889083153442132 0.708064651201742 0.384615384615385 12.1 12 1 small interparietal bone 0.505633342116376 0.889083153442132 0.708064651201742 0.384615384615385 12.1 12 1 decreased endocochlear potential 0.505633342116376 0.889083153442132 0.708064651201742 0.384615384615385 12.1 12 1 increased circulating thyroid-stimulating hormone level 0.505633342116376 0.889083153442132 0.708064651201742 0.384615384615385 12.1 12 1 abnormal vertebral arch development 0.505633342116376 0.889083153442132 0.708064651201742 0.384615384615385 12.1 12 1 abnormal aorta tunica media morphology 0.505633342116376 0.889083153442132 0.708064651201742 0.384615384615385 12.1 12 1 abnormal gut flora balance 0.505633342116376 0.889083153442132 0.708064651201742 0.384615384615385 12.1 12 1 abnormal hair follicle inner root sheath morphology 0.505633342116376 0.889083153442132 0.708064651201742 0.384615384615385 12.1 12 1 abnormal CNS synaptic transmission 0.285741547671556 0.711722627184227 0.70663421756295 0.383838383838384 12.1 12 1 overexpanded pulmonary alveoli 0.417618766010022 0.810317223439882 0.703899565018202 0.382352941176471 12.1 12 1 thin skin 0.417618766010022 0.810317223439882 0.703899565018202 0.382352941176471 12.1 12 1 increased anxiety-related response 0.26081000074225 0.711722627184227 0.701951862846043 0.381294964028777 12.1 12 1 abnormal optic nerve morphology 0.402719998835536 0.784775555897685 0.701321178333154 0.380952380952381 12.1 12 1 small ears 0.471232176557489 0.849479754082158 0.701321178333154 0.380952380952381 12.1 12 1 increased vasoconstriction 0.471232176557489 0.849479754082158 0.701321178333154 0.380952380952381 12.1 12 1 dry skin 0.471232176557489 0.849479754082158 0.701321178333154 0.380952380952381 12.1 12 1 complete atrioventricular septal defect 0.471232176557489 0.849479754082158 0.701321178333154 0.380952380952381 12.1 12 1 abnormal axon extension 0.389732005486268 0.768496522906929 0.699567875387321 0.38 12.1 12 1 cochlear ganglion degeneration 0.378129143900031 0.747989061989127 0.698298242219649 0.379310344827586 12.1 12 1 abnormal middle ear morphology 0.447289342835268 0.819618593224846 0.698298242219649 0.379310344827586 12.1 12 1 abnormal circulating glucose level 0.447289342835268 0.819618593224846 0.698298242219649 0.379310344827586 12.1 12 1 abnormal spinal nerve morphology 0.447289342835268 0.819618593224846 0.698298242219649 0.379310344827586 12.1 12 1 stomach inflammation 0.447289342835268 0.819618593224846 0.698298242219649 0.379310344827586 12.1 12 1 abnormal breathing pattern 0.428444460033143 0.811537219104749 0.696582521722795 0.378378378378378 12.1 12 1 impaired skeletal muscle contractility 0.428444460033143 0.811537219104749 0.696582521722795 0.378378378378378 12.1 12 1 increased insulin secretion 0.428444460033143 0.811537219104749 0.696582521722795 0.378378378378378 12.1 12 1 polyuria 0.365512384512342 0.723894949422334 0.693351619488459 0.376623376623377 12.1 12 1 abnormal auditory brainstem response waveform shape 0.457955382681668 0.836541604118899 0.690363034921698 0.375 12.1 12 1 vasculature congestion 0.516812720609362 0.889083153442132 0.690363034921698 0.375 12.1 12 1 reduced male mating frequency 0.516812720609362 0.889083153442132 0.690363034921698 0.375 12.1 12 1 abnormal intestinal absorption 0.516812720609362 0.889083153442132 0.690363034921698 0.375 12.1 12 1 abnormal epicardium morphology 0.516812720609362 0.889083153442132 0.690363034921698 0.375 12.1 12 1 paternal imprinting 0.516812720609362 0.889083153442132 0.690363034921698 0.375 12.1 12 1 impaired muscle relaxation 0.516812720609362 0.889083153442132 0.690363034921698 0.375 12.1 12 1 bowed tibia 0.516812720609362 0.889083153442132 0.690363034921698 0.375 12.1 12 1 abnormal wound healing 0.516812720609362 0.889083153442132 0.690363034921698 0.375 12.1 12 1 decreased circulating prolactin level 0.516812720609362 0.889083153442132 0.690363034921698 0.375 12.1 12 1 impaired behavioral response to addictive substance 0.516812720609362 0.889083153442132 0.690363034921698 0.375 12.1 12 1 increased heart left ventricle size 0.516812720609362 0.889083153442132 0.690363034921698 0.375 12.1 12 1 increased liver weight 0.363098708744865 0.722566430402282 0.690363034921698 0.375 12.1 12 1 abnormal hair shaft morphology 0.421931156259652 0.81147829011675 0.690363034921698 0.375 12.1 12 1 increased susceptibility to weight loss 0.438378429207968 0.811537219104749 0.690363034921698 0.375 12.1 12 1 abnormal digestive system morphology 0.482576020260827 0.866720469602027 0.690363034921698 0.375 12.1 12 1 increased stereotypic behavior 0.482576020260827 0.866720469602027 0.690363034921698 0.375 12.1 12 1 decreased fatty acid level 0.482576020260827 0.866720469602027 0.690363034921698 0.375 12.1 12 1 polyphagia 0.438788193738185 0.811537219104749 0.681840034490566 0.37037037037037 12.1 12 1 abnormal long bone epiphyseal plate proliferative zone 0.438788193738185 0.811537219104749 0.681840034490566 0.37037037037037 12.1 12 1 abnormal brain commissure morphology 0.49254661969252 0.876715360633377 0.681840034490566 0.37037037037037 12.1 12 1 abnormal bone trabecula morphology 0.49254661969252 0.876715360633377 0.681840034490566 0.37037037037037 12.1 12 1 abnormal retinal outer nuclear layer morphology 0.476459494124645 0.856662805663213 0.67825140273009 0.368421052631579 12.1 12 1 stereotypic behavior 0.52619144268267 0.889083153442132 0.67825140273009 0.368421052631579 12.1 12 1 abnormal long term depression 0.52619144268267 0.889083153442132 0.67825140273009 0.368421052631579 12.1 12 1 increased left ventricle weight 0.52619144268267 0.889083153442132 0.67825140273009 0.368421052631579 12.1 12 1 abnormal hair cycle 0.501459460444428 0.889083153442132 0.675021634145661 0.366666666666667 12.1 12 1 abnormal neuron differentiation 0.411945609021527 0.799933413302927 0.673925819804515 0.366071428571429 12.1 12 1 abnormal excitatory postsynaptic potential 0.437071879169655 0.811537219104749 0.67352491211873 0.365853658536585 12.1 12 1 abnormal response/metabolism to endogenous compounds 0.437071879169655 0.811537219104749 0.67352491211873 0.365853658536585 12.1 12 1 abnormal cholesterol homeostasis 0.48461207414112 0.870063178943368 0.67352491211873 0.365853658536585 12.1 12 1 decreased kidney weight 0.47156367170654 0.849479754082158 0.672661418641655 0.365384615384615 12.1 12 1 increased susceptibility to injury 0.47156367170654 0.849479754082158 0.672661418641655 0.365384615384615 12.1 12 1 increased myocardial infarction size 0.53433285090851 0.889083153442132 0.669442942954374 0.363636363636364 12.1 12 1 increased coping response 0.53433285090851 0.889083153442132 0.669442942954374 0.363636363636364 12.1 12 1 abnormal cochlear sensory epithelium morphology 0.53433285090851 0.889083153442132 0.669442942954374 0.363636363636364 12.1 12 1 abnormal retinal layer morphology 0.53433285090851 0.889083153442132 0.669442942954374 0.363636363636364 12.1 12 1 failure of palatal shelf elevation 0.53433285090851 0.889083153442132 0.669442942954374 0.363636363636364 12.1 12 1 abnormal tibia morphology 0.499251894841991 0.888332681272856 0.665882076236532 0.361702127659574 12.1 12 1 short radius 0.5169259141774 0.889083153442132 0.664794033628302 0.361111111111111 12.1 12 1 head tilt 0.5169259141774 0.889083153442132 0.664794033628302 0.361111111111111 12.1 12 1 abnormal vertebrae development 0.541569967160734 0.889083153442132 0.66274851352483 0.36 12.1 12 1 abnormal lens fiber morphology 0.523754260196039 0.889083153442132 0.660860341121626 0.358974358974359 12.1 12 1 abnormal cartilage morphology 0.530107671533113 0.889083153442132 0.657488604687332 0.357142857142857 12.1 12 1 dehydration 0.508982113759314 0.889083153442132 0.657488604687332 0.357142857142857 12.1 12 1 abnormal vibrissa morphology 0.530107671533113 0.889083153442132 0.657488604687332 0.357142857142857 12.1 12 1 abnormal action potential 0.508982113759314 0.889083153442132 0.657488604687332 0.357142857142857 12.1 12 1 abnormal respiration 0.548115722653957 0.889083153442132 0.657488604687332 0.357142857142857 12.1 12 1 abnormal hormone level 0.548115722653957 0.889083153442132 0.657488604687332 0.357142857142857 12.1 12 1 decreased circulating progesterone level 0.548115722653957 0.889083153442132 0.657488604687332 0.357142857142857 12.1 12 1 increased triglyceride level 0.548115722653957 0.889083153442132 0.657488604687332 0.357142857142857 12.1 12 1 corneal vascularization 0.548115722653957 0.889083153442132 0.657488604687332 0.357142857142857 12.1 12 1 abnormal blood flow velocity 0.583487801487814 0.891813152811637 0.657488604687332 0.357142857142857 12.1 12 1 absent atrioventricular cushions 0.583487801487814 0.891813152811637 0.657488604687332 0.357142857142857 12.1 12 1 abnormal zigzag hair morphology 0.583487801487814 0.891813152811637 0.657488604687332 0.357142857142857 12.1 12 1 abnormal pinna reflex 0.583487801487814 0.891813152811637 0.657488604687332 0.357142857142857 12.1 12 1 abnormal decidualization 0.583487801487814 0.891813152811637 0.657488604687332 0.357142857142857 12.1 12 1 increased circulating growth hormone level 0.583487801487814 0.891813152811637 0.657488604687332 0.357142857142857 12.1 12 1 decreased tongue size 0.583487801487814 0.891813152811637 0.657488604687332 0.357142857142857 12.1 12 1 increased lung compliance 0.583487801487814 0.891813152811637 0.657488604687332 0.357142857142857 12.1 12 1 abnormal respiratory motile cilium physiology 0.583487801487814 0.891813152811637 0.657488604687332 0.357142857142857 12.1 12 1 abnormal colon morphology 0.523694633654986 0.889083153442132 0.655259829756188 0.355932203389831 12.1 12 1 decreased cardiac muscle contractility 0.504749731215074 0.889083153442132 0.654959802361611 0.355769230769231 12.1 12 1 decreased neuronal precursor cell number 0.55411446412506 0.889083153442132 0.653246742721607 0.354838709677419 12.1 12 1 abnormal phalanx morphology 0.541653590193596 0.889083153442132 0.652009532981604 0.354166666666667 12.1 12 1 impaired synaptic plasticity 0.559668580011659 0.889083153442132 0.649753444632187 0.352941176470588 12.1 12 1 enlarged sebaceous gland 0.587115487955419 0.895981457846077 0.649753444632187 0.352941176470588 12.1 12 1 abnormal glutamate-mediated receptor currents 0.587115487955419 0.895981457846077 0.649753444632187 0.352941176470588 12.1 12 1 decreased vasoconstriction 0.587115487955419 0.895981457846077 0.649753444632187 0.352941176470588 12.1 12 1 decreased growth hormone level 0.587115487955419 0.895981457846077 0.649753444632187 0.352941176470588 12.1 12 1 abnormal electroretinogram waveform feature 0.587115487955419 0.895981457846077 0.649753444632187 0.352941176470588 12.1 12 1 abnormal mandible morphology 0.551968934101609 0.889083153442132 0.647748032766038 0.351851851851852 12.1 12 1 abnormal humerus morphology 0.564853368505539 0.889083153442132 0.646826627314024 0.351351351351351 12.1 12 1 abnormal basioccipital bone morphology 0.590739587457588 0.899855923944121 0.644338832593585 0.35 12.1 12 1 abnormal dopamine level 0.590739587457588 0.899855923944121 0.644338832593585 0.35 12.1 12 1 abnormal trachea morphology 0.590739587457588 0.899855923944121 0.644338832593585 0.35 12.1 12 1 abnormal lens epithelium morphology 0.590739587457588 0.899855923944121 0.644338832593585 0.35 12.1 12 1 abnormal heart right ventricle morphology 0.590739587457588 0.899855923944121 0.644338832593585 0.35 12.1 12 1 abnormal heart electrocardiography waveform feature 0.590739587457588 0.899855923944121 0.644338832593585 0.35 12.1 12 1 abnormal blood circulation 0.57433032676326 0.889083153442132 0.642198172020184 0.348837209302326 12.1 12 1 impaired swimming 0.569905315947552 0.889083153442132 0.641549486997942 0.348484848484849 12.1 12 1 abnormal food intake 0.573950826942746 0.889083153442132 0.640336728043314 0.347826086956522 12.1 12 1 fragile skeleton 0.594305107660299 0.90390336612962 0.640336728043314 0.347826086956522 12.1 12 1 abnormal carpal bone morphology 0.594305107660299 0.90390336612962 0.640336728043314 0.347826086956522 12.1 12 1 abnormal corneal stroma morphology 0.594305107660299 0.90390336612962 0.640336728043314 0.347826086956522 12.1 12 1 increased susceptibility to fungal infection 0.594305107660299 0.90390336612962 0.640336728043314 0.347826086956522 12.1 12 1 abnormal stomach morphology 0.597788874865379 0.908924099161144 0.637258186081568 0.346153846153846 12.1 12 1 hydronephrosis 0.592222918240229 0.901839307696707 0.635572317864421 0.345238095238095 12.1 12 1 increased susceptibility to pharmacologically induced seizures 0.605011523963382 0.919344023127009 0.632832782011557 0.34375 12.1 12 1 abnormal urine homeostasis 0.605011523963382 0.919344023127009 0.632832782011557 0.34375 12.1 12 1 short mandible 0.627962427547566 0.953927657114242 0.624614174452965 0.339285714285714 12.1 12 1 syndactyly 0.630589813638109 0.957626472176311 0.624056980720179 0.338983050847458 12.1 12 1 abnormal anxiety-related response 0.650493292907638 0.986603671350386 0.61365603104151 0.333333333333333 12.1 12 1 abnormal pain threshold 0.651043627299793 0.986603671350386 0.61365603104151 0.333333333333333 12.1 12 1 abnormal sensory capabilities/reflexes/nociception 0.650169651360034 0.986603671350386 0.61365603104151 0.333333333333333 12.1 12 1 abnormal stapes morphology 0.650493292907638 0.986603671350386 0.61365603104151 0.333333333333333 12.1 12 1 decreased vocalization 0.650493292907638 0.986603671350386 0.61365603104151 0.333333333333333 12.1 12 1 interdigital webbing 0.654118395599262 0.987030336095337 0.61365603104151 0.333333333333333 12.1 12 1 vagina atresia 0.654118395599262 0.987030336095337 0.61365603104151 0.333333333333333 12.1 12 1 abnormal apical ectodermal ridge morphology 0.654118395599262 0.987030336095337 0.61365603104151 0.333333333333333 12.1 12 1 abnormal bronchus morphology 0.654118395599262 0.987030336095337 0.61365603104151 0.333333333333333 12.1 12 1 increased alcohol consumption 0.654118395599262 0.987030336095337 0.61365603104151 0.333333333333333 12.1 12 1 dilated ureter 0.654118395599262 0.987030336095337 0.61365603104151 0.333333333333333 12.1 12 1 decreased aggression towards males 0.654118395599262 0.987030336095337 0.61365603104151 0.333333333333333 12.1 12 1 abnormal Muller cell morphology 0.654118395599262 0.987030336095337 0.61365603104151 0.333333333333333 12.1 12 1 abnormal secondary palate development 0.654118395599262 0.987030336095337 0.61365603104151 0.333333333333333 12.1 12 1 lactation failure 0.654118395599262 0.987030336095337 0.61365603104151 0.333333333333333 12.1 12 1 increased kidney weight 0.660314764663856 0.991867739795496 0.61365603104151 0.333333333333333 12.1 12 1 delayed kidney development 0.651654203830627 0.986603671350386 0.61365603104151 0.333333333333333 12.1 12 1 thick dermal layer 0.651654203830627 0.986603671350386 0.61365603104151 0.333333333333333 12.1 12 1 increased circulating renin level 0.651654203830627 0.986603671350386 0.61365603104151 0.333333333333333 12.1 12 1 abnormal body wall morphology 0.651654203830627 0.986603671350386 0.61365603104151 0.333333333333333 12.1 12 1 abnormal sperm axoneme morphology 0.651654203830627 0.986603671350386 0.61365603104151 0.333333333333333 12.1 12 1 abnormal systemic arterial blood pressure 0.653078615348662 0.987030336095337 0.61365603104151 0.333333333333333 12.1 12 1 small lens 0.654350144677387 0.987080645776228 0.61365603104151 0.333333333333333 12.1 12 1 abnormal cartilage development 0.657203481015244 0.989819116308447 0.61365603104151 0.333333333333333 12.1 12 1 abnormal eye electrophysiology 0.720063256047055 1 0.608584493594886 0.330578512396694 12.1 12 1 absent kidney 0.695519559191504 1 0.601132438571275 0.326530612244898 12.1 12 1 increased fluid intake 0.695519559191504 1 0.601132438571275 0.326530612244898 12.1 12 1 impaired righting response 0.734205257655959 1 0.600736956703794 0.326315789473684 12.1 12 1 delayed wound healing 0.695188144966101 1 0.600315682540607 0.326086956521739 12.1 12 1 decreased pancreatic beta cell number 0.69609728216363 1 0.595607324246171 0.323529411764706 12.1 12 1 increased width of hypertrophic chondrocyte zone 0.69609728216363 1 0.595607324246171 0.323529411764706 12.1 12 1 increased susceptibility to weight gain 0.69609728216363 1 0.595607324246171 0.323529411764706 12.1 12 1 abnormal cranial ganglia morphology 0.697200371668714 1 0.593860675201461 0.32258064516129 12.1 12 1 abnormal hindlimb morphology 0.729869880106326 1 0.589109789799849 0.32 12.1 12 1 diaphragmatic hernia 0.701275385100881 1 0.589109789799849 0.32 12.1 12 1 abnormal energy expenditure 0.701275385100881 1 0.589109789799849 0.32 12.1 12 1 impaired conditioned place preference behavior 0.701275385100881 1 0.589109789799849 0.32 12.1 12 1 abnormal stomach mucosa morphology 0.701275385100881 1 0.589109789799849 0.32 12.1 12 1 abnormal innervation 0.730569337941875 1 0.587543008443999 0.319148936170213 12.1 12 1 abnormal channel response 0.704701499173897 1 0.585762575085077 0.318181818181818 12.1 12 1 abnormal temporal bone morphology 0.704701499173897 1 0.585762575085077 0.318181818181818 12.1 12 1 increased circulating creatine kinase level 0.704701499173897 1 0.585762575085077 0.318181818181818 12.1 12 1 short humerus 0.732811992603792 1 0.583721590502899 0.317073170731707 12.1 12 1 abnormal kidney development 0.758507022849918 1 0.582973229489434 0.316666666666667 12.1 12 1 flaky skin 0.709560093591223 1 0.58135834519722 0.315789473684211 12.1 12 1 unresponsive to tactile stimuli 0.709560093591223 1 0.58135834519722 0.315789473684211 12.1 12 1 abnormal neurotransmitter level 0.709560093591223 1 0.58135834519722 0.315789473684211 12.1 12 1 increased circulating VLDL cholesterol level 0.709560093591223 1 0.58135834519722 0.315789473684211 12.1 12 1 hyporesponsive to tactile stimuli 0.734476834133249 1 0.58135834519722 0.315789473684211 12.1 12 1 abnormal behavioral response to xenobiotic 0.709560093591223 1 0.58135834519722 0.315789473684211 12.1 12 1 abnormal lymphatic vessel morphology 0.739344401160908 1 0.575302529101415 0.3125 12.1 12 1 abnormal long term potentiation 0.739344401160908 1 0.575302529101415 0.3125 12.1 12 1 abnormal pulmonary elastic fiber morphology 0.716530066049216 1 0.575302529101415 0.3125 12.1 12 1 decreased aggression towards mice 0.716530066049216 1 0.575302529101415 0.3125 12.1 12 1 abnormal epididymis epithelium morphology 0.716530066049216 1 0.575302529101415 0.3125 12.1 12 1 abnormal level of surface class II molecules 0.716530066049216 1 0.575302529101415 0.3125 12.1 12 1 abnormal serotonin level 0.739344401160908 1 0.575302529101415 0.3125 12.1 12 1 loose skin 0.716530066049216 1 0.575302529101415 0.3125 12.1 12 1 kidney degeneration 0.716530066049216 1 0.575302529101415 0.3125 12.1 12 1 dilated respiratory conducting tubes 0.716530066049216 1 0.575302529101415 0.3125 12.1 12 1 abnormal nervous system electrophysiology 0.82350754323919 1 0.569823457395688 0.30952380952381 12.1 12 1 abnormal kidney cortex morphology 0.747269389649992 1 0.566451720961394 0.307692307692308 12.1 12 1 no spontaneous movement 0.747269389649992 1 0.566451720961394 0.307692307692308 12.1 12 1 abnormal excitatory postsynaptic currents 0.82572857944826 1 0.566451720961394 0.307692307692308 12.1 12 1 abnormal blood vessel physiology 0.752999920461097 1 0.5602946370379 0.304347826086957 12.1 12 1 abnormal innervation pattern to muscle 0.752999920461097 1 0.5602946370379 0.304347826086957 12.1 12 1 blistering 0.752999920461097 1 0.5602946370379 0.304347826086957 12.1 12 1 hypotension 0.752999920461097 1 0.5602946370379 0.304347826086957 12.1 12 1 decreased systemic arterial blood pressure 0.777338234531485 1 0.557869119128645 0.303030303030303 12.1 12 1 abnormal middle ear ossicle morphology 0.777338234531485 1 0.557869119128645 0.303030303030303 12.1 12 1 head tossing 0.777338234531485 1 0.557869119128645 0.303030303030303 12.1 12 1 delayed eyelid opening 0.782156323716168 1 0.552290427937359 0.3 12.1 12 1 emphysema 0.782156323716168 1 0.552290427937359 0.3 12.1 12 1 decreased paired-pulse facilitation 0.760483167648496 1 0.552290427937359 0.3 12.1 12 1 abnormal synaptic transmission 0.782156323716168 1 0.552290427937359 0.3 12.1 12 1 kidney atrophy 0.760483167648496 1 0.552290427937359 0.3 12.1 12 1 abnormal incus morphology 0.760483167648496 1 0.552290427937359 0.3 12.1 12 1 abnormal femur morphology 0.852481664752968 1 0.549542714365531 0.298507462686567 12.1 12 1 abnormal trigeminal nerve morphology 0.788052289522911 1 0.545472027592453 0.296296296296296 12.1 12 1 decreased susceptibility to pharmacologically induced seizures 0.788052289522911 1 0.545472027592453 0.296296296296296 12.1 12 1 short maxilla 0.811188631351425 1 0.541461203860156 0.294117647058824 12.1 12 1 abnormal touch/ nociception 0.770452806921631 1 0.541461203860156 0.294117647058824 12.1 12 1 increased trabecular bone mass 0.770452806921631 1 0.541461203860156 0.294117647058824 12.1 12 1 apnea 0.795341795973299 1 0.536949027161321 0.291666666666667 12.1 12 1 decreased ovulation rate 0.795341795973299 1 0.536949027161321 0.291666666666667 12.1 12 1 abnormal osteoblast morphology 0.795341795973299 1 0.536949027161321 0.291666666666667 12.1 12 1 abnormal retinal ganglion layer morphology 0.795341795973299 1 0.536949027161321 0.291666666666667 12.1 12 1 decreased food intake 0.896096342103661 1 0.53597805242866 0.291139240506329 12.1 12 1 abnormal autopod morphology 0.851974525342247 1 0.531835226902642 0.288888888888889 12.1 12 1 hypoalgesia 0.804479117544839 1 0.525990883749865 0.285714285714286 12.1 12 1 abnormal stria vascularis morphology 0.823727130284391 1 0.525990883749865 0.285714285714286 12.1 12 1 myoclonus 0.823727130284391 1 0.525990883749865 0.285714285714286 12.1 12 1 increased circulating luteinizing hormone level 0.823727130284391 1 0.525990883749865 0.285714285714286 12.1 12 1 abnormal inner ear vestibule morphology 0.831923177979239 1 0.515471066074868 0.28 12.1 12 1 abnormal heart shape 0.816144577341248 1 0.511380025867925 0.277777777777778 12.1 12 1 abnormal stomach glandular epithelium morphology 0.816144577341248 1 0.511380025867925 0.277777777777778 12.1 12 1 abnormal retinal rod cell morphology 0.816144577341248 1 0.511380025867925 0.277777777777778 12.1 12 1 acidosis 0.816144577341248 1 0.511380025867925 0.277777777777778 12.1 12 1 absent ureter 0.816144577341248 1 0.511380025867925 0.277777777777778 12.1 12 1 abnormal eye anterior chamber morphology 0.816144577341248 1 0.511380025867925 0.277777777777778 12.1 12 1 head bobbing 0.883812212566288 1 0.506266225609246 0.275 12.1 12 1 decreased airway responsiveness 0.841895724433942 1 0.502082207215781 0.272727272727273 12.1 12 1 decreased cardiac output 0.841895724433942 1 0.502082207215781 0.272727272727273 12.1 12 1 short ulna 0.903193936251872 1 0.493918268887069 0.268292682926829 12.1 12 1 abnormal estrous cycle 0.880872158903036 1 0.490924824833208 0.266666666666667 12.1 12 1 decreased urine osmolality 0.925106612645316 1 0.488420106339161 0.26530612244898 12.1 12 1 abnormal inhibitory postsynaptic currents 0.951751454983168 1 0.48731508347414 0.264705882352941 12.1 12 1 abnormal bone remodeling 0.895911760309346 1 0.48731508347414 0.264705882352941 12.1 12 1 abnormal triglyceride level 0.854210464394827 1 0.48446528766435 0.263157894736842 12.1 12 1 abnormal nail morphology 0.854210464394827 1 0.48446528766435 0.263157894736842 12.1 12 1 decreased grooming behavior 0.854210464394827 1 0.48446528766435 0.263157894736842 12.1 12 1 abnormal ear morphology 0.854210464394827 1 0.48446528766435 0.263157894736842 12.1 12 1 maternal imprinting 0.854210464394827 1 0.48446528766435 0.263157894736842 12.1 12 1 osteoarthritis 0.854210464394827 1 0.48446528766435 0.263157894736842 12.1 12 1 impaired branching involved in ureteric bud morphogenesis 0.90875716681811 1 0.48446528766435 0.263157894736842 12.1 12 1 eyelids fail to open 0.854210464394827 1 0.48446528766435 0.263157894736842 12.1 12 1 abnormal basicranium morphology 0.873270714071417 1 0.480252546032486 0.260869565217391 12.1 12 1 abnormal hepatocyte physiology 0.873270714071417 1 0.480252546032486 0.260869565217391 12.1 12 1 abnormal digestive system physiology 0.937641267371698 1 0.478651704212378 0.26 12.1 12 1 abnormal cochlea morphology 0.94486645184682 1 0.477288024143396 0.259259259259259 12.1 12 1 wrinkled skin 0.889382109976395 1 0.477288024143396 0.259259259259259 12.1 12 1 abnormal body temperature homeostasis 0.903119507609503 1 0.475088540161169 0.258064516129032 12.1 12 1 abnormal iris morphology 0.925095235282049 1 0.472043100801161 0.256410256410256 12.1 12 1 abnormal axon guidance 0.933925419630072 1 0.470945326148135 0.255813953488372 12.1 12 1 abnormal diaphragm morphology 0.92173827980609 1 0.460242023281132 0.25 12.1 12 1 abnormal malleus morphology 0.899247020104123 1 0.460242023281132 0.25 12.1 12 1 abnormal reflex 0.930872647637003 1 0.460242023281132 0.25 12.1 12 1 decreased skin tensile strength 0.885452896643605 1 0.460242023281132 0.25 12.1 12 1 abnormal male reproductive system physiology 0.885452896643605 1 0.460242023281132 0.25 12.1 12 1 increased percent body fat/body weight 0.95737922914356 1 0.460242023281132 0.25 12.1 12 1 single kidney 0.937179313439131 1 0.446295295302916 0.242424242424242 12.1 12 1 aphagia 0.929314110895413 1 0.444371608685231 0.241379310344828 12.1 12 1 absent long term depression 0.929314110895413 1 0.444371608685231 0.241379310344828 12.1 12 1 abnormal feces composition 0.920507180775138 1 0.441832342349887 0.24 12.1 12 1 abnormal bile salt homeostasis 0.910757202611969 1 0.438325736458221 0.238095238095238 12.1 12 1 increased systemic arterial blood pressure 0.97106467597083 1 0.430864872858932 0.234042553191489 12.1 12 1 abnormal intestine physiology 0.955997507111676 1 0.415702472641023 0.225806451612903 12.1 12 1 abnormal single cell response 0.9515384246425 1 0.40910402069434 0.222222222222222 12.1 12 1 abnormal retinal cone cell morphology 0.947049429789812 1 0.400210455027072 0.217391304347826 12.1 12 1 increased susceptibility to age related obesity 0.947049429789812 1 0.400210455027072 0.217391304347826 12.1 12 1 abnormal crista ampullaris morphology 0.947049429789812 1 0.400210455027072 0.217391304347826 12.1 12 1 abnormal ureter morphology 0.97695317335223 1 0.354032325600871 0.192307692307692 12.1 12 1 abnormal tectorial membrane morphology 0.97695317335223 1 0.354032325600871 0.192307692307692 12.1 12 1 increased dopamine level 0.987311229148066 1 0.345181517460849 0.1875 12.1 12 1 impaired behavioral response to xenobiotic 0.994639491127385 1 0.315594530249919 0.171428571428571 12.1 12 1 abnormal leukocyte tethering or rolling 0.00025381860964186 0.00528346269024374 2.97329585382994 1 12.3 12 3 abnormal NK cell morphology 1.60592989338918e-05 0.00049317908763032 2.97329585382994 1 12.3 12 3 abnormal second pharyngeal arch artery morphology 0.00100893864062372 0.0160880440291764 2.97329585382994 1 12.3 12 3 decreased CD8-positive, alpha-beta memory T cell number 0.00100893864062372 0.0160880440291764 2.97329585382994 1 12.3 12 3 abnormal kidney epithelium morphology 0.000398365113244785 0.0075643757190565 2.60163387210119 0.875 12.3 12 3 vascular smooth muscle hypoplasia 3.44815013629828e-06 0.000120806668507634 2.5485393032828 0.857142857142857 12.3 12 3 abnormal hypersensitivity reaction 0.0013936451131565 0.0207890599262393 2.5485393032828 0.857142857142857 12.3 12 3 decreased mortality induced by ionizing radiation 0.0013936451131565 0.0207890599262393 2.5485393032828 0.857142857142857 12.3 12 3 increased tumor latency 0.0013936451131565 0.0207890599262393 2.5485393032828 0.857142857142857 12.3 12 3 interstitial pneumonia 3.99204345828551e-05 0.00109726056381052 2.47774654485828 0.833333333333333 12.3 12 3 decreased red blood cell distribution width 3.99204345828551e-05 0.00109726056381052 2.47774654485828 0.833333333333333 12.3 12 3 abnormal lymph node cortex morphology 0.00478453879553305 0.0524296927484073 2.47774654485828 0.833333333333333 12.3 12 3 decreased heart right ventricle size 0.00478453879553305 0.0524296927484073 2.47774654485828 0.833333333333333 12.3 12 3 decreased DN1 thymic pro-T cell number 0.00478453879553305 0.0524296927484073 2.47774654485828 0.833333333333333 12.3 12 3 abnormal cytotoxic T cell physiology 5.12515356787595e-14 7.72655727278268e-12 2.40695378643376 0.80952380952381 12.3 12 3 abnormal thymocyte activation 4.22970273564777e-07 1.81403199222825e-05 2.37863668306395 0.8 12.3 12 3 increased natural killer cell mediated cytotoxicity 0.000436116780391703 0.00800620288726466 2.37863668306395 0.8 12.3 12 3 decreased transitional stage T2 B cell number 0.000436116780391703 0.00800620288726466 2.37863668306395 0.8 12.3 12 3 acanthocytosis 0.000436116780391703 0.00800620288726466 2.37863668306395 0.8 12.3 12 3 abnormal positive T cell selection 4.24439768309077e-05 0.00116021310293278 2.33616102800924 0.785714285714286 12.3 12 3 abnormal Peyer's patch follicle morphology 4.27328229806546e-06 0.000148668387642487 2.31256344186773 0.777777777777778 12.3 12 3 decreased cellular sensitivity to ionizing radiation 0.00139986634679199 0.0207890599262393 2.31256344186773 0.777777777777778 12.3 12 3 decreased transitional stage T1 B cell number 0.00139986634679199 0.0207890599262393 2.31256344186773 0.777777777777778 12.3 12 3 decreased cytotoxic T cell cytolysis 5.11236095483313e-10 3.85363571974164e-08 2.27369682939936 0.764705882352941 12.3 12 3 abnormal thymus involution 0.000412559277899498 0.00774521663226416 2.22997189037245 0.75 12.3 12 3 decreased mammary gland epithelial cell proliferation 0.000412559277899498 0.00774521663226416 2.22997189037245 0.75 12.3 12 3 abnormal eyelid aperture 0.00437948511289165 0.0492384473337963 2.22997189037245 0.75 12.3 12 3 abnormal extraembryonic tissue physiology 0.00437948511289165 0.0492384473337963 2.22997189037245 0.75 12.3 12 3 craniofacial phenotype 0.00437948511289165 0.0492384473337963 2.22997189037245 0.75 12.3 12 3 abnormal mitotic spindle assembly checkpoint 0.00437948511289165 0.0492384473337963 2.22997189037245 0.75 12.3 12 3 delayed suture closure 0.00437948511289165 0.0492384473337963 2.22997189037245 0.75 12.3 12 3 abnormal macrophage activation involved in immune response 0.00437948511289165 0.0492384473337963 2.22997189037245 0.75 12.3 12 3 abnormal T cell proliferation 1.42000377546154e-08 8.1201365320933e-07 2.20599369800286 0.741935483870968 12.3 12 3 impaired natural killer cell mediated cytotoxicity 2.0826393914986e-14 3.98505037411751e-12 2.19084957650627 0.736842105263158 12.3 12 3 delayed intramembranous bone ossification 0.000122716328341391 0.00285286791354401 2.18041695947529 0.733333333333333 12.3 12 3 abnormal CD8-positive, alpha-beta T cell physiology 1.23726808328299e-07 5.80698935314423e-06 2.15307630794582 0.724137931034483 12.3 12 3 abnormal NK cell physiology 1.80975735166633e-14 3.66092905370394e-12 2.14467241915602 0.721311475409836 12.3 12 3 abnormal maternal decidual layer morphology 0.00036163199743603 0.00705536936174216 2.12378275273567 0.714285714285714 12.3 12 3 cellular necrosis 0.0132617730014744 0.113558211157204 2.12378275273567 0.714285714285714 12.3 12 3 broad head 0.0132617730014744 0.113558211157204 2.12378275273567 0.714285714285714 12.3 12 3 abnormal circulating alanine transaminase level 0.0132617730014744 0.113558211157204 2.12378275273567 0.714285714285714 12.3 12 3 decreased activated T cell number 0.0132617730014744 0.113558211157204 2.12378275273567 0.714285714285714 12.3 12 3 abnormal gastrulation movements 0.0132617730014744 0.113558211157204 2.12378275273567 0.714285714285714 12.3 12 3 aorta coarctation 0.0132617730014744 0.113558211157204 2.12378275273567 0.714285714285714 12.3 12 3 abnormal MHC II cell surface expression on macrophages 0.0132617730014744 0.113558211157204 2.12378275273567 0.714285714285714 12.3 12 3 decreased tidal volume 0.0132617730014744 0.113558211157204 2.12378275273567 0.714285714285714 12.3 12 3 absent popliteal lymph nodes 0.0132617730014744 0.113558211157204 2.12378275273567 0.714285714285714 12.3 12 3 heart hemorrhage 0.0132617730014744 0.113558211157204 2.12378275273567 0.714285714285714 12.3 12 3 arteritis 0.0132617730014744 0.113558211157204 2.12378275273567 0.714285714285714 12.3 12 3 decreased brain cholesterol level 0.0132617730014744 0.113558211157204 2.12378275273567 0.714285714285714 12.3 12 3 decreased T-helper 17 cell number 0.0132617730014744 0.113558211157204 2.12378275273567 0.714285714285714 12.3 12 3 embryonic lethality at implantation, incomplete penetrance 0.0132617730014744 0.113558211157204 2.12378275273567 0.714285714285714 12.3 12 3 increased circulating lactate dehydrogenase level 0.0132617730014744 0.113558211157204 2.12378275273567 0.714285714285714 12.3 12 3 decreased CD8-positive, naive alpha-beta T cell number 0.0132617730014744 0.113558211157204 2.12378275273567 0.714285714285714 12.3 12 3 ductus venosus stenosis 0.0132617730014744 0.113558211157204 2.12378275273567 0.714285714285714 12.3 12 3 embryo tumor 0.0132617730014744 0.113558211157204 2.12378275273567 0.714285714285714 12.3 12 3 inner cell mass degeneration 1.10480035431546e-07 5.28498246415329e-06 2.11008092852447 0.709677419354839 12.3 12 3 decreased T cell proliferation 1.07883249083777e-30 1.07343832838358e-27 2.08934303242104 0.702702702702703 12.3 12 3 abnormal immune cell physiology 0.00364861533505933 0.0447090179603945 2.08130709768096 0.7 12.3 12 3 increased atrioventricular cushion size 0.00364861533505933 0.0447090179603945 2.08130709768096 0.7 12.3 12 3 absent inguinal lymph nodes 0.00364861533505933 0.0447090179603945 2.08130709768096 0.7 12.3 12 3 abnormal inferior vena cava valve morphology 0.00364861533505933 0.0447090179603945 2.08130709768096 0.7 12.3 12 3 decreased macrophage cytokine production 0.00364861533505933 0.0447090179603945 2.08130709768096 0.7 12.3 12 3 decreased macrophage apoptosis 0.00364861533505933 0.0447090179603945 2.08130709768096 0.7 12.3 12 3 increased fatty acid oxidation 0.00364861533505933 0.0447090179603945 2.08130709768096 0.7 12.3 12 3 increased hepatocellular carcinoma incidence 8.10049407186131e-12 8.22448122602245e-10 2.03436032104154 0.684210526315789 12.3 12 3 decreased tumor incidence 8.95417621960442e-05 0.00219445320042758 2.03436032104154 0.684210526315789 12.3 12 3 spleen hyperplasia 7.4219749527541e-15 1.61546938916144e-12 2.02184118060436 0.68 12.3 12 3 increased susceptibility to viral infection induced morbidity/mortality 2.26556146899904e-07 1.01542056831263e-05 2.0113471952379 0.676470588235294 12.3 12 3 abnormal erythropoiesis 6.62102019338416e-20 2.74496462184052e-17 2.01051433925643 0.676190476190476 12.3 12 3 abnormal redox activity 0.000246557374302588 0.00523358081401405 1.98219723588662 0.666666666666667 12.3 12 3 abnormal macrophage chemotaxis 0.000246557374302588 0.00523358081401405 1.98219723588662 0.666666666666667 12.3 12 3 impaired leukocyte tethering or rolling 0.000246557374302588 0.00523358081401405 1.98219723588662 0.666666666666667 12.3 12 3 heart hyperplasia 0.010338722645091 0.0966826036829465 1.98219723588662 0.666666666666667 12.3 12 3 distorted hair follicle pattern 0.010338722645091 0.0966826036829465 1.98219723588662 0.666666666666667 12.3 12 3 crypts of Lieberkuhn abscesses 0.010338722645091 0.0966826036829465 1.98219723588662 0.666666666666667 12.3 12 3 decreased level of surface class I molecules 0.010338722645091 0.0966826036829465 1.98219723588662 0.666666666666667 12.3 12 3 abnormal thymus lobule morphology 0.010338722645091 0.0966826036829465 1.98219723588662 0.666666666666667 12.3 12 3 abnormal posterior semicircular canal morphology 0.010338722645091 0.0966826036829465 1.98219723588662 0.666666666666667 12.3 12 3 abnormal thymus physiology 0.010338722645091 0.0966826036829465 1.98219723588662 0.666666666666667 12.3 12 3 abnormal leukopoiesis 0.010338722645091 0.0966826036829465 1.98219723588662 0.666666666666667 12.3 12 3 decreased effector memory CD4-positive, alpha-beta T cell number 0.010338722645091 0.0966826036829465 1.98219723588662 0.666666666666667 12.3 12 3 increased myeloid cell number 0.010338722645091 0.0966826036829465 1.98219723588662 0.666666666666667 12.3 12 3 abnormal tumor morphology 2.19815526942201e-05 0.000647090086708551 1.98219723588662 0.666666666666667 12.3 12 3 abnormal dendritic cell morphology 0.000839463335625311 0.0141570511685964 1.98219723588662 0.666666666666667 12.3 12 3 increased papilloma incidence 0.0029075248652136 0.0383685310462538 1.98219723588662 0.666666666666667 12.3 12 3 altered tumor susceptibility 0.0029075248652136 0.0383685310462538 1.98219723588662 0.666666666666667 12.3 12 3 increased fibrosarcoma incidence 0.0029075248652136 0.0383685310462538 1.98219723588662 0.666666666666667 12.3 12 3 prenatal growth retardation 0.0029075248652136 0.0383685310462538 1.98219723588662 0.666666666666667 12.3 12 3 abnormal vitelline vein connection 0.0029075248652136 0.0383685310462538 1.98219723588662 0.666666666666667 12.3 12 3 abnormal CD4-positive, alpha-beta T cell physiology 3.91594148013871e-13 4.99533560607438e-11 1.96823810042263 0.661971830985915 12.3 12 3 increased cellular sensitivity to gamma-irradiation 4.5188561288585e-09 2.77547027667544e-07 1.96111003124953 0.659574468085106 12.3 12 3 increased mortality induced by gamma-irradiation 5.39356850129608e-06 0.000181304076310459 1.94802142147479 0.655172413793103 12.3 12 3 abnormal physiological neovascularization 0.000196713427005649 0.00436897008639778 1.93264230498946 0.65 12.3 12 3 abnormal CD8-positive, alpha beta T cell morphology 4.3310227059331e-06 0.000149630819180675 1.9182553895677 0.645161290322581 12.3 12 3 lymphoid hyperplasia 1.41989891866444e-05 0.000438757585115255 1.9114044774621 0.642857142857143 12.3 12 3 increased hemangioma incidence 0.00226141634237664 0.0310788571915022 1.9114044774621 0.642857142857143 12.3 12 3 lysosomal protein accumulation 0.00226141634237664 0.0310788571915022 1.9114044774621 0.642857142857143 12.3 12 3 increased B cell derived lymphoma incidence 7.78240801891208e-09 4.55499763459854e-07 1.90290934645116 0.64 12.3 12 3 abnormal T cell subpopulation ratio 3.44476184952005e-06 0.000120806668507634 1.89209736152814 0.636363636363636 12.3 12 3 abnormal sphenoid bone morphology 0.00785631684248916 0.0777915603919163 1.89209736152814 0.636363636363636 12.3 12 3 impaired myelopoiesis 0.00785631684248916 0.0777915603919163 1.89209736152814 0.636363636363636 12.3 12 3 vasculitis 0.00785631684248916 0.0777915603919163 1.89209736152814 0.636363636363636 12.3 12 3 loss of cortex neurons 0.00785631684248916 0.0777915603919163 1.89209736152814 0.636363636363636 12.3 12 3 increased number of Howell-Jolly bodies 0.00785631684248916 0.0777915603919163 1.89209736152814 0.636363636363636 12.3 12 3 abnormal T cell activation 3.7412779818743e-12 3.96018254464354e-10 1.88844466391901 0.635135135135135 12.3 12 3 decreased B cell proliferation 9.40953211042997e-13 1.11458148212831e-10 1.88183281887971 0.632911392405063 12.3 12 3 abnormal lymphocyte physiology 6.41006644031014e-08 3.1890080540543e-06 1.87446912524061 0.630434782608696 12.3 12 3 impaired hematopoiesis 1.58349058772082e-08 8.95212008398988e-07 1.86559739848153 0.627450980392157 12.3 12 3 increased T cell proliferation 2.99293838842197e-16 8.2721491568885e-14 1.86178338510847 0.626168224299065 12.3 12 3 vertebral transformation 5.0658564797111e-08 2.59820989552193e-06 1.85830990864371 0.625 12.3 12 3 large intestinal inflammation 0.00173360922569742 0.0249268956585106 1.85830990864371 0.625 12.3 12 3 decreased liver cholesterol level 0.00173360922569742 0.0249268956585106 1.85830990864371 0.625 12.3 12 3 schistocytosis 0.0280655861491124 0.195201073780778 1.85830990864371 0.625 12.3 12 3 increased sensitivity to skin irradiation 0.0280655861491124 0.195201073780778 1.85830990864371 0.625 12.3 12 3 preneoplasia 0.0280655861491124 0.195201073780778 1.85830990864371 0.625 12.3 12 3 binucleate 0.0280655861491124 0.195201073780778 1.85830990864371 0.625 12.3 12 3 lymph node inflammation 0.0280655861491124 0.195201073780778 1.85830990864371 0.625 12.3 12 3 accumulation of giant lysosomes in kidney/renal tubule cells 0.0280655861491124 0.195201073780778 1.85830990864371 0.625 12.3 12 3 enlarged inguinal lymph nodes 0.0280655861491124 0.195201073780778 1.85830990864371 0.625 12.3 12 3 myocardial trabeculae hypoplasia 0.0280655861491124 0.195201073780778 1.85830990864371 0.625 12.3 12 3 decreased cranium length 0.0280655861491124 0.195201073780778 1.85830990864371 0.625 12.3 12 3 embryo cyst 0.0280655861491124 0.195201073780778 1.85830990864371 0.625 12.3 12 3 increased mammary gland apoptosis 0.0280655861491124 0.195201073780778 1.85830990864371 0.625 12.3 12 3 increased brain apoptosis 0.0280655861491124 0.195201073780778 1.85830990864371 0.625 12.3 12 3 decreased vascular endothelial cell proliferation 0.0280655861491124 0.195201073780778 1.85830990864371 0.625 12.3 12 3 abnormal definitive hematopoiesis 3.76191471988759e-14 6.45362956256578e-12 1.85431354324878 0.623655913978495 12.3 12 3 decreased double-positive T cell number 7.46850169863579e-15 1.61546938916144e-12 1.84344342937456 0.62 12.3 12 3 abnormal hematopoietic system physiology 0.000397273071974011 0.0075643757190565 1.84061171903758 0.619047619047619 12.3 12 3 abnormal tumor vascularization 0.000397273071974011 0.0075643757190565 1.84061171903758 0.619047619047619 12.3 12 3 abnormal spleen red pulp morphology 6.86774588053719e-06 0.000223313959187402 1.83644743913025 0.617647058823529 12.3 12 3 decreased Peyer's patch number 9.31098888993595e-05 0.00225961803548446 1.82972052543381 0.615384615384615 12.3 12 3 increased foot pad pigmentation 0.00589536239940594 0.0621386185106876 1.82972052543381 0.615384615384615 12.3 12 3 abnormal megakaryocyte differentiation 0.00131685937515725 0.0201580781274071 1.81701413289607 0.611111111111111 12.3 12 3 absent inner cell mass 0.00131685937515725 0.0201580781274071 1.81701413289607 0.611111111111111 12.3 12 3 decreased tumor latency 0.00131685937515725 0.0201580781274071 1.81701413289607 0.611111111111111 12.3 12 3 increased effector memory CD8-positive, alpha-beta T cell number 0.00131685937515725 0.0201580781274071 1.81701413289607 0.611111111111111 12.3 12 3 increased B cell proliferation 6.00599438130422e-09 3.59997855987813e-07 1.81421441928606 0.610169491525424 12.3 12 3 abnormal cell differentiation 1.29048741230944e-06 5.13613990099157e-05 1.81298527672557 0.609756097560976 12.3 12 3 increased lung adenocarcinoma incidence 7.70647952138787e-08 3.79601342761432e-06 1.80729747977898 0.607843137254902 12.3 12 3 small liver 5.52776172057377e-11 4.91082402854545e-09 1.7916013478206 0.602564102564103 12.3 12 3 abnormal liver development 1.30915512800355e-05 0.000409625582504255 1.78397751229796 0.6 12.3 12 3 abnormal lymph node B cell domain morphology 0.00439434585250363 0.0492384473337963 1.78397751229796 0.6 12.3 12 3 abnormal placenta size 0.00439434585250363 0.0492384473337963 1.78397751229796 0.6 12.3 12 3 immune system phenotype 0.00439434585250363 0.0492384473337963 1.78397751229796 0.6 12.3 12 3 decreased thymocyte apoptosis 0.00439434585250363 0.0492384473337963 1.78397751229796 0.6 12.3 12 3 abnormal microglial cell activation 0.00439434585250363 0.0492384473337963 1.78397751229796 0.6 12.3 12 3 spleen atrophy 0.000994247347133189 0.0160077040517399 1.78397751229796 0.6 12.3 12 3 increased skin tumor incidence 0.000994247347133189 0.0160077040517399 1.78397751229796 0.6 12.3 12 3 abnormal mammary gland physiology 0.0203738836101385 0.151283688000655 1.78397751229796 0.6 12.3 12 3 peritoneal inflammation 0.0203738836101385 0.151283688000655 1.78397751229796 0.6 12.3 12 3 osteosclerosis 0.0203738836101385 0.151283688000655 1.78397751229796 0.6 12.3 12 3 increased platelet aggregation 0.0203738836101385 0.151283688000655 1.78397751229796 0.6 12.3 12 3 absent axillary lymph nodes 0.0203738836101385 0.151283688000655 1.78397751229796 0.6 12.3 12 3 abnormal T-helper 1 physiology 5.91045542101155e-07 2.49190811182479e-05 1.77132518951571 0.595744680851064 12.3 12 3 pale liver 4.15070694359063e-10 3.22652610068178e-08 1.7679056428178 0.594594594594595 12.3 12 3 extramedullary hematopoiesis 7.68407145273389e-14 1.06189598548197e-11 1.76714753576685 0.594339622641509 12.3 12 3 decreased circulating fructosamine level 0.000175136478844428 0.00390719274552032 1.76195309856589 0.592592592592593 12.3 12 3 increased sarcoma incidence 4.53072576376153e-07 1.92652655339433e-05 1.75970570940955 0.591836734693878 12.3 12 3 abnormal germ layer development 0.000747572639269431 0.0128247375185014 1.75694754999042 0.590909090909091 12.3 12 3 intestinal inflammation 0.000747572639269431 0.0128247375185014 1.75694754999042 0.590909090909091 12.3 12 3 abnormal vascular branching morphogenesis 0.000747572639269431 0.0128247375185014 1.75694754999042 0.590909090909091 12.3 12 3 increased adenoma incidence 0.000747572639269431 0.0128247375185014 1.75694754999042 0.590909090909091 12.3 12 3 increased autoantibody level 7.63203872266624e-06 0.000244963823517836 1.7534821702074 0.58974358974359 12.3 12 3 decreased B-1 B cell number 7.63203872266624e-06 0.000244963823517836 1.7534821702074 0.58974358974359 12.3 12 3 decreased regulatory T cell number 3.16299864286701e-05 0.000895871615653786 1.74899756107643 0.588235294117647 12.3 12 3 pancytopenia 0.00326335679070729 0.0418432990561051 1.74899756107643 0.588235294117647 12.3 12 3 abnormal circulating chemokine level 0.00326335679070729 0.0418432990561051 1.74899756107643 0.588235294117647 12.3 12 3 thymus hypoplasia 6.35094807550302e-17 1.97474791722672e-14 1.7451953924654 0.58695652173913 12.3 12 3 decreased granulocyte number 0.000132303898278869 0.00303323453427361 1.74296653500376 0.586206896551724 12.3 12 3 abnormal embryonic erythropoiesis 0.000132303898278869 0.00303323453427361 1.74296653500376 0.586206896551724 12.3 12 3 decreased lymphocyte cell number 1.00904132628035e-15 2.50999029912237e-13 1.74216553935348 0.5859375 12.3 12 3 small lymph nodes 0.000560478593469244 0.00992306406587007 1.7344225814008 0.583333333333333 12.3 12 3 loss of dopaminergic neurons 0.0147846256106749 0.122999184637304 1.7344225814008 0.583333333333333 12.3 12 3 small intestinal inflammation 0.0147846256106749 0.122999184637304 1.7344225814008 0.583333333333333 12.3 12 3 increased osteosarcoma incidence 0.0147846256106749 0.122999184637304 1.7344225814008 0.583333333333333 12.3 12 3 abnormal defecation 0.0147846256106749 0.122999184637304 1.7344225814008 0.583333333333333 12.3 12 3 pale placenta 0.0147846256106749 0.122999184637304 1.7344225814008 0.583333333333333 12.3 12 3 abnormal B cell proliferation 0.0147846256106749 0.122999184637304 1.7344225814008 0.583333333333333 12.3 12 3 abnormal fatty acid level 0.0147846256106749 0.122999184637304 1.7344225814008 0.583333333333333 12.3 12 3 abnormal thymus corticomedullary boundary morphology 0.0147846256106749 0.122999184637304 1.7344225814008 0.583333333333333 12.3 12 3 increased monocyte cell number 3.1116976736612e-12 3.36536867966619e-10 1.72451159522136 0.58 12.3 12 3 increased liver adenoma incidence 0.00241841639779555 0.0331449630276388 1.72138181011207 0.578947368421053 12.3 12 3 abnormal osteoclast physiology 2.89096177691969e-08 1.53601772694139e-06 1.71893666549543 0.578125 12.3 12 3 liver hypoplasia 6.21722929142063e-07 2.59921980880821e-05 1.71536299259419 0.576923076923077 12.3 12 3 decreased bone resorption 0.000419349164501605 0.00781371570560106 1.71536299259419 0.576923076923077 12.3 12 3 increased thymocyte apoptosis 0.000419349164501605 0.00781371570560106 1.71536299259419 0.576923076923077 12.3 12 3 abnormal cell cycle 2.02871325896819e-13 2.65601275351756e-11 1.70641327263283 0.573913043478261 12.3 12 3 thrombocytopenia 2.11344992640366e-16 6.18494904932837e-14 1.70195555770955 0.572413793103448 12.3 12 3 increased T cell derived lymphoma incidence 1.91003099089077e-06 7.19879104521333e-05 1.69902620218854 0.571428571428571 12.3 12 3 abnormal mitotic spindle morphology 0.000313296363780447 0.0062345976392309 1.69902620218854 0.571428571428571 12.3 12 3 subcutaneous edema 0.000313296363780447 0.0062345976392309 1.69902620218854 0.571428571428571 12.3 12 3 abnormal vascular endothelial cell migration 0.0107406238087783 0.0984062678612749 1.69902620218854 0.571428571428571 12.3 12 3 increased B-1 B cell number 0.0107406238087783 0.0984062678612749 1.69902620218854 0.571428571428571 12.3 12 3 increased stomach tumor incidence 0.0107406238087783 0.0984062678612749 1.69902620218854 0.571428571428571 12.3 12 3 abnormal vitelline vein topology 0.0107406238087783 0.0984062678612749 1.69902620218854 0.571428571428571 12.3 12 3 decreased response to antigen 0.0107406238087783 0.0984062678612749 1.69902620218854 0.571428571428571 12.3 12 3 abnormal response to infection 1.82633721983212e-09 1.21147035582197e-07 1.69364953699174 0.569620253164557 12.3 12 3 abnormal myelopoiesis 7.76544737846152e-06 0.000247648081460552 1.68937264422155 0.568181818181818 12.3 12 3 increased granulocyte number 7.28717537152464e-09 4.31591636587322e-07 1.68754629541699 0.567567567567568 12.3 12 3 abnormal hematopoietic stem cell physiology 0.00132444169308227 0.0202119552855346 1.68055852607779 0.565217391304348 12.3 12 3 abnormal leukocyte adhesion 3.16931466040334e-05 0.000895871615653786 1.67724381498099 0.564102564102564 12.3 12 3 impaired macrophage chemotaxis 3.16931466040334e-05 0.000895871615653786 1.67724381498099 0.564102564102564 12.3 12 3 abnormal lymph node morphology 4.391240194722e-06 0.000149633013484534 1.67247891777934 0.5625 12.3 12 3 thymus atrophy 4.391240194722e-06 0.000149633013484534 1.67247891777934 0.5625 12.3 12 3 increased fibroblast apoptosis 0.000174367156958249 0.00390719274552032 1.67247891777934 0.5625 12.3 12 3 impaired somite development 0.00781529294411163 0.0777915603919163 1.67247891777934 0.5625 12.3 12 3 decreased fibroblast apoptosis 0.00781529294411163 0.0777915603919163 1.67247891777934 0.5625 12.3 12 3 decreased bone marrow cell number 1.66025319791049e-08 9.28062883101651e-07 1.6699332877675 0.561643835616438 12.3 12 3 abnormal cell morphology 1.83591533149174e-12 2.07583608503895e-10 1.66921872495716 0.56140350877193 12.3 12 3 abnormal cytokine secretion 4.75954562065411e-16 1.24624944540812e-13 1.66041197032061 0.558441558441558 12.3 12 3 abnormal leukocyte migration 2.47621460128336e-06 9.1253093639887e-05 1.65818422617439 0.557692307692308 12.3 12 3 kinked neural tube 2.47621460128336e-06 9.1253093639887e-05 1.65818422617439 0.557692307692308 12.3 12 3 increased double-negative T cell number 3.4938269441388e-07 1.51145991713831e-05 1.65724686934783 0.557377049180328 12.3 12 3 decreased IgM level 1.48320279315646e-10 1.27222998206093e-08 1.65523686708058 0.556701030927835 12.3 12 3 abnormal neutrophil morphology 0.00569647856014486 0.0604024460299576 1.65183102990552 0.555555555555556 12.3 12 3 increased effector memory CD4-positive, alpha-beta T cell number 0.00569647856014486 0.0604024460299576 1.65183102990552 0.555555555555556 12.3 12 3 abnormal aerobic respiration 0.00569647856014486 0.0604024460299576 1.65183102990552 0.555555555555556 12.3 12 3 abnormal hypoglossal nerve topology 0.00569647856014486 0.0604024460299576 1.65183102990552 0.555555555555556 12.3 12 3 multifocal hepatic necrosis 0.0502241655291393 0.291078233348796 1.65183102990552 0.555555555555556 12.3 12 3 abnormal gallbladder physiology 0.0502241655291393 0.291078233348796 1.65183102990552 0.555555555555556 12.3 12 3 liver hyperplasia 0.0502241655291393 0.291078233348796 1.65183102990552 0.555555555555556 12.3 12 3 absent cervical lymph nodes 0.0502241655291393 0.291078233348796 1.65183102990552 0.555555555555556 12.3 12 3 abnormal liver vasculature morphology 0.0502241655291393 0.291078233348796 1.65183102990552 0.555555555555556 12.3 12 3 axonal spheroids 0.0502241655291393 0.291078233348796 1.65183102990552 0.555555555555556 12.3 12 3 shortened ST segment 0.0502241655291393 0.291078233348796 1.65183102990552 0.555555555555556 12.3 12 3 iris coloboma 0.0502241655291393 0.291078233348796 1.65183102990552 0.555555555555556 12.3 12 3 abnormal oxidative phosphorylation 0.0502241655291393 0.291078233348796 1.65183102990552 0.555555555555556 12.3 12 3 increased core body temperature 0.0502241655291393 0.291078233348796 1.65183102990552 0.555555555555556 12.3 12 3 decreased bone trabecular spacing 0.0502241655291393 0.291078233348796 1.65183102990552 0.555555555555556 12.3 12 3 abnormal infrahyoid muscle connection 0.0502241655291393 0.291078233348796 1.65183102990552 0.555555555555556 12.3 12 3 symmetric azygos veins 0.0502241655291393 0.291078233348796 1.65183102990552 0.555555555555556 12.3 12 3 increased cardiac muscle glycogen level 0.0502241655291393 0.291078233348796 1.65183102990552 0.555555555555556 12.3 12 3 cerebellum atrophy 0.0502241655291393 0.291078233348796 1.65183102990552 0.555555555555556 12.3 12 3 decreased platelet dense granule number 0.0502241655291393 0.291078233348796 1.65183102990552 0.555555555555556 12.3 12 3 pale yolk sac 4.04581933170371e-09 2.51599389690325e-07 1.64785071417081 0.55421686746988 12.3 12 3 abnormal neural tube closure 4.04581933170371e-09 2.51599389690325e-07 1.64785071417081 0.55421686746988 12.3 12 3 incomplete somite formation 7.21219041975427e-05 0.00185910089835635 1.6431371823797 0.552631578947368 12.3 12 3 abnormal humoral immune response 4.8003691738683e-11 4.34215211636269e-09 1.64239199544892 0.552380952380952 12.3 12 3 abnormal embryonic neuroepithelium morphology 1.04468103841172e-06 4.2952794761143e-05 1.64043909176824 0.551724137931034 12.3 12 3 increased double-positive T cell number 0.00053605632132085 0.00969774617662265 1.64043909176824 0.551724137931034 12.3 12 3 blood in lymph vessels 0.00053605632132085 0.00969774617662265 1.64043909176824 0.551724137931034 12.3 12 3 liver inflammation 2.98611998471484e-12 3.30132153865697e-10 1.63531271960647 0.55 12.3 12 3 increased mammary adenocarcinoma incidence 0.00415906745971623 0.0483443004955333 1.63531271960646 0.55 12.3 12 3 abnormal Peyer's patch T cell area morphology 0.00415906745971623 0.0483443004955333 1.63531271960646 0.55 12.3 12 3 abnormal induced retinal neovascularization 0.00415906745971623 0.0483443004955333 1.63531271960646 0.55 12.3 12 3 abnormal B cell differentiation 1.29809978570981e-09 8.84663895055659e-08 1.6336790405659 0.549450549450549 12.3 12 3 increased tumor incidence 1.69438016387776e-12 1.96035844541671e-10 1.63051708113255 0.548387096774194 12.3 12 3 increased B cell number 8.75631602152126e-12 8.71253444141365e-10 1.62641824483005 0.547008547008547 12.3 12 3 decreased circulating serum albumin level 4.14572171971841e-10 3.22652610068178e-08 1.62179773845269 0.545454545454545 12.3 12 3 decreased circulating total protein level 3.103972311112e-06 0.000110301873198444 1.62179773845269 0.545454545454545 12.3 12 3 enlarged pericardium 0.000293593657520172 0.00593783245171165 1.62179773845269 0.545454545454545 12.3 12 3 increased skin papilloma incidence 0.00304138153703661 0.0394033154863467 1.62179773845269 0.545454545454545 12.3 12 3 abnormal mesenteric lymph node morphology 0.00304138153703661 0.0394033154863467 1.62179773845269 0.545454545454545 12.3 12 3 decreased susceptibility to viral infection induced morbidity/mortality 0.00304138153703661 0.0394033154863467 1.62179773845269 0.545454545454545 12.3 12 3 delayed hepatic development 0.0353949637313176 0.233541040534887 1.62179773845269 0.545454545454545 12.3 12 3 abnormal eye distance/ position 0.0353949637313176 0.233541040534887 1.62179773845269 0.545454545454545 12.3 12 3 pharyngeal arch hypoplasia 0.0353949637313176 0.233541040534887 1.62179773845269 0.545454545454545 12.3 12 3 cyclopia 0.0353949637313176 0.233541040534887 1.62179773845269 0.545454545454545 12.3 12 3 abnormal dorsal-ventral polarity of the somites 0.0353949637313176 0.233541040534887 1.62179773845269 0.545454545454545 12.3 12 3 aorta dilation 0.0353949637313176 0.233541040534887 1.62179773845269 0.545454545454545 12.3 12 3 abnormal extraembryonic ectoderm morphology 0.0353949637313176 0.233541040534887 1.62179773845269 0.545454545454545 12.3 12 3 chylous ascites 0.0353949637313176 0.233541040534887 1.62179773845269 0.545454545454545 12.3 12 3 hypolactation 0.0353949637313176 0.233541040534887 1.62179773845269 0.545454545454545 12.3 12 3 increased leukocyte cell number 4.50076231668111e-14 6.99727891421516e-12 1.61993360312114 0.544827586206897 12.3 12 3 increased neutrophil cell number 4.50076231668111e-14 6.99727891421516e-12 1.61993360312114 0.544827586206897 12.3 12 3 embryonic lethality between implantation and placentation, complete penetrance 2.21734431006342e-05 0.000648899290739148 1.61592165969018 0.543478260869565 12.3 12 3 increased circulating serum albumin level 0.0002173786580251 0.00480648366077722 1.61407489207911 0.542857142857143 12.3 12 3 enlarged spleen 5.650172066499e-26 3.51370075385407e-23 1.61053525415788 0.541666666666667 12.3 12 3 decreased metastatic potential 0.00222730717444312 0.0307801477579292 1.61053525415788 0.541666666666667 12.3 12 3 hemolytic anemia 0.00222730717444312 0.0307801477579292 1.61053525415788 0.541666666666667 12.3 12 3 abnormal cellular extravasation 0.00222730717444312 0.0307801477579292 1.61053525415788 0.541666666666667 12.3 12 3 anemia 2.89022569080699e-19 1.10606713936652e-16 1.60642524804082 0.540284360189573 12.3 12 3 absent teeth 0.0251554326904888 0.180069464223283 1.60100545975458 0.538461538461538 12.3 12 3 absent common myeloid progenitor cells 0.0251554326904888 0.180069464223283 1.60100545975458 0.538461538461538 12.3 12 3 abnormal mast cell morphology 0.0251554326904888 0.180069464223283 1.60100545975458 0.538461538461538 12.3 12 3 lymphoid hypoplasia 0.0251554326904888 0.180069464223283 1.60100545975458 0.538461538461538 12.3 12 3 abnormal pulmonary alveolus epithelial cell morphology 0.0251554326904888 0.180069464223283 1.60100545975458 0.538461538461538 12.3 12 3 abnormal coping response 0.0251554326904888 0.180069464223283 1.60100545975458 0.538461538461538 12.3 12 3 orthokeratosis 0.0251554326904888 0.180069464223283 1.60100545975458 0.538461538461538 12.3 12 3 absent hypoglossal nerve 0.0251554326904888 0.180069464223283 1.60100545975458 0.538461538461538 12.3 12 3 abnormal spleen germinal center morphology 0.00119921347287226 0.0185859408957617 1.59283706455175 0.535714285714286 12.3 12 3 abnormal brainstem morphology 0.00119921347287226 0.0185859408957617 1.59283706455175 0.535714285714286 12.3 12 3 decreased embryo size 1.28128036434624e-40 2.21430052839435e-37 1.59239275853654 0.535564853556485 12.3 12 3 abnormal double-strand DNA break repair 6.55506621897869e-05 0.00170740599159262 1.59036754972299 0.534883720930233 12.3 12 3 decreased B cell number 3.88573258905314e-18 1.28876797536929e-15 1.58768225204511 0.533980582524272 12.3 12 3 arrested T cell differentiation 0.000881472972907696 0.0146040512569554 1.5857577887093 0.533333333333333 12.3 12 3 macrocytosis 0.0179935129016637 0.138358155619439 1.5857577887093 0.533333333333333 12.3 12 3 decreased hepatocyte number 0.0179935129016637 0.138358155619439 1.5857577887093 0.533333333333333 12.3 12 3 abnormal hepatocyte morphology 2.59923598265076e-10 2.11986869076845e-08 1.58040049888258 0.531531531531532 12.3 12 3 increased spleen weight 1.94566009363791e-10 1.6132764943081e-08 1.57874116132563 0.530973451327434 12.3 12 3 failure of chorioallantoic fusion 1.98709600725668e-05 0.000596155528279168 1.57409780496879 0.529411764705882 12.3 12 3 abnormal bone marrow cavity morphology 0.0129362211166915 0.113558211157204 1.57409780496879 0.529411764705882 12.3 12 3 decreased erythrocyte cell number 9.84415767128104e-14 1.32364011931414e-11 1.57186978259799 0.528662420382166 12.3 12 3 embryonic lethality before implantation, complete penetrance 3.41963151259138e-11 3.2099371273853e-09 1.56990021082221 0.528 12.3 12 3 decreased T cell number 5.52196481124577e-14 8.07993380469051e-12 1.56975246941332 0.527950310559006 12.3 12 3 abnormal lysosome morphology 0.000352112045936902 0.00689668278951215 1.56923947841024 0.527777777777778 12.3 12 3 embryonic lethality between implantation and somite formation, complete penetrance 2.58611267561412e-20 1.28659105611803e-17 1.56553128630229 0.526530612244898 12.3 12 3 decreased hair follicle number 0.000259759498286446 0.00536225520321604 1.56489255464734 0.526315789473684 12.3 12 3 small superior vagus ganglion 0.00933876985164407 0.0891753934969852 1.56489255464734 0.526315789473684 12.3 12 3 altered susceptibility to infection 0.00933876985164407 0.0891753934969852 1.56489255464734 0.526315789473684 12.3 12 3 preweaning lethality, complete penetrance 6.23860300841204e-58 3.10370499668499e-54 1.5589713395757 0.524324324324324 12.3 12 3 spleen hypoplasia 2.10403977124367e-09 1.37709770783329e-07 1.55744068533949 0.523809523809524 12.3 12 3 abnormal spleen white pulp morphology 0.000141672676975407 0.0032183633239847 1.55744068533949 0.523809523809524 12.3 12 3 abnormal salivary gland morphology 0.0067648073133241 0.0692487991435954 1.55744068533949 0.523809523809524 12.3 12 3 embryonic lethality at implantation, complete penetrance 0.0067648073133241 0.0692487991435954 1.55744068533949 0.523809523809524 12.3 12 3 absent segment of posterior cerebral artery 0.0067648073133241 0.0692487991435954 1.55744068533949 0.523809523809524 12.3 12 3 increased lymphocyte cell number 1.37633136528492e-06 5.39153428526968e-05 1.55128479330258 0.521739130434783 12.3 12 3 abnormal cell death 7.74633254695735e-05 0.00194636385965216 1.55128479330258 0.521739130434783 12.3 12 3 failure of embryo implantation 0.0049144068213504 0.0536166095092506 1.55128479330258 0.521739130434783 12.3 12 3 decreased effector memory CD8-positive, alpha-beta T cell number 0.0049144068213504 0.0536166095092506 1.55128479330258 0.521739130434783 12.3 12 3 pallor 2.41406769011962e-14 4.28928098512325e-12 1.54611384399157 0.52 12.3 12 3 abnormal thyroid gland morphology 0.00357894207648038 0.0446246537105009 1.54611384399157 0.52 12.3 12 3 spontaneous skin ulceration 0.00357894207648038 0.0446246537105009 1.54611384399157 0.52 12.3 12 3 abnormal egg cylinder morphology 0.00357894207648038 0.0446246537105009 1.54611384399157 0.52 12.3 12 3 increased pre-B cell number 0.00357894207648038 0.0446246537105009 1.54611384399157 0.52 12.3 12 3 abnormal preimplantation embryo development 0.00357894207648038 0.0446246537105009 1.54611384399157 0.52 12.3 12 3 decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 0.00357894207648038 0.0446246537105009 1.54611384399157 0.52 12.3 12 3 abnormal apoptosis 2.33038752282497e-05 0.000674051042212456 1.54170896124515 0.518518518518518 12.3 12 3 decreased tumor growth/size 2.33038752282497e-05 0.000674051042212456 1.54170896124515 0.518518518518518 12.3 12 3 increased grip strength 5.37752500612461e-08 2.7299170311704e-06 1.53565829813195 0.516483516483517 12.3 12 3 autoimmune response 0.00139860941499547 0.0207890599262393 1.53460431165416 0.516129032258065 12.3 12 3 abnormal mitochondrial ATP synthesis coupled electron transport 0.00139860941499547 0.0207890599262393 1.53460431165416 0.516129032258065 12.3 12 3 increased inflammatory response 2.98753243494128e-08 1.56452356461399e-06 1.53359470355439 0.515789473684211 12.3 12 3 myeloid hyperplasia 0.00102576676667672 0.0163041203329606 1.53169786409421 0.515151515151515 12.3 12 3 lung inflammation 4.12402581687216e-11 3.79944971091463e-09 1.53037286594188 0.514705882352941 12.3 12 3 decreased circulating alanine transaminase level 2.89118044970225e-06 0.00010347930026812 1.53037286594188 0.514705882352941 12.3 12 3 decreased mean corpuscular hemoglobin 2.89118044970225e-06 0.00010347930026812 1.53037286594188 0.514705882352941 12.3 12 3 abnormal midbrain development 0.000753291778088839 0.0128784419106253 1.52912358196968 0.514285714285714 12.3 12 3 lethality throughout fetal growth and development, incomplete penetrance 4.3656838157382e-14 6.99727891421516e-12 1.52817440532041 0.513966480446927 12.3 12 3 abnormal inflammatory response 1.59694433750256e-06 6.06473135807271e-05 1.52794370266261 0.513888888888889 12.3 12 3 malocclusion 0.000553838398506218 0.00984052154488727 1.52682760061537 0.513513513513513 12.3 12 3 increased erythroid progenitor cell number 0.000553838398506218 0.00984052154488727 1.52682760061537 0.513513513513513 12.3 12 3 abnormal respiratory electron transport chain 0.000553838398506218 0.00984052154488727 1.52682760061537 0.513513513513513 12.3 12 3 decreased IgG level 2.85709354761201e-09 1.82231287171407e-07 1.52682760061537 0.513513513513513 12.3 12 3 abnormal embryo size 2.13138740709876e-09 1.37709770783329e-07 1.52611645594811 0.513274336283186 12.3 12 3 increased hepatocyte apoptosis 0.000407623403791508 0.00771074689681654 1.52476710452817 0.512820512820513 12.3 12 3 embryonic lethality during organogenesis, complete penetrance 1.33525660003679e-40 2.21430052839435e-37 1.52381412508784 0.5125 12.3 12 3 hemopericardium 0.000300295639200144 0.00602407582669645 1.52290763244948 0.51219512195122 12.3 12 3 increased bone trabecula number 0.000300295639200144 0.00602407582669645 1.52290763244948 0.51219512195122 12.3 12 3 impaired macrophage phagocytosis 0.00022141954960796 0.00483141341798071 1.52122113451764 0.511627906976744 12.3 12 3 increased T cell number 1.49950286269107e-07 6.84406123108998e-06 1.5204353797994 0.511363636363636 12.3 12 3 trabecula carnea hypoplasia 0.000163390823832408 0.00369486067530105 1.51968454751308 0.511111111111111 12.3 12 3 abnormal cell nucleus morphology 0.00012065788527591 0.00282973465213765 1.51827873387061 0.51063829787234 12.3 12 3 abnormal head morphology 3.61050053008388e-05 0.0010091146144476 1.51367788922251 0.509090909090909 12.3 12 3 microcephaly 4.45058391895539e-06 0.000150623503379613 1.50819354904417 0.507246376811594 12.3 12 3 anophthalmia 2.29509346941237e-07 1.01947232235058e-05 1.50335183620615 0.50561797752809 12.3 12 3 abnormal vitelline vasculature morphology 4.99311135977065e-09 3.02935719693402e-07 1.49957530019249 0.504347826086956 12.3 12 3 abnormal extraembryonic tissue morphology 5.91370446810947e-08 2.97178583119643e-06 1.48664792691497 0.5 12.3 12 3 abnormal immune system morphology 0.000249318322195242 0.00523358081401405 1.48664792691497 0.5 12.3 12 3 failure to gastrulate 0.000249318322195242 0.00523358081401405 1.48664792691497 0.5 12.3 12 3 abnormal myelin sheath morphology 0.000249318322195242 0.00523358081401405 1.48664792691497 0.5 12.3 12 3 increased bone marrow cell number 0.000847917298725993 0.0142513127066277 1.48664792691497 0.5 12.3 12 3 abnormal trophoblast giant cell morphology 0.00115447151024078 0.018061307432226 1.48664792691497 0.5 12.3 12 3 enlarged liver sinusoidal spaces 0.00157385421701165 0.0230291903812734 1.48664792691497 0.5 12.3 12 3 abnormal brown adipose tissue morphology 0.00157385421701165 0.0230291903812734 1.48664792691497 0.5 12.3 12 3 increased metastatic potential 0.00293800501187554 0.0384646708791601 1.48664792691497 0.5 12.3 12 3 salivary gland inflammation 0.00293800501187554 0.0384646708791601 1.48664792691497 0.5 12.3 12 3 abnormal brain vasculature morphology 0.00293800501187554 0.0384646708791601 1.48664792691497 0.5 12.3 12 3 abnormal leukocyte cell number 0.00552456243766039 0.0592342632055181 1.48664792691497 0.5 12.3 12 3 increased leukemia incidence 0.00552456243766039 0.0592342632055181 1.48664792691497 0.5 12.3 12 3 abnormal nerve conduction 0.00552456243766039 0.0592342632055181 1.48664792691497 0.5 12.3 12 3 increased hemangiosarcoma incidence 0.00760150646825772 0.0765536329546198 1.48664792691497 0.5 12.3 12 3 abnormal inner cell mass apoptosis 0.00760150646825772 0.0765536329546198 1.48664792691497 0.5 12.3 12 3 abnormal chorion morphology 0.0104882330896116 0.0969869137933413 1.48664792691497 0.5 12.3 12 3 abnormal female reproductive system physiology 0.0104882330896116 0.0969869137933413 1.48664792691497 0.5 12.3 12 3 abnormal sperm midpiece morphology 0.0104882330896116 0.0969869137933413 1.48664792691497 0.5 12.3 12 3 abnormal cerebral cortex pyramidal cell morphology 0.0104882330896116 0.0969869137933413 1.48664792691497 0.5 12.3 12 3 increased bone volume 0.0104882330896116 0.0969869137933413 1.48664792691497 0.5 12.3 12 3 embryonic lethality before implantation, incomplete penetrance 0.0104882330896116 0.0969869137933413 1.48664792691497 0.5 12.3 12 3 underdeveloped hair follicles 0.0201759636732382 0.151167800111988 1.48664792691497 0.5 12.3 12 3 abnormal iron level 0.0201759636732382 0.151167800111988 1.48664792691497 0.5 12.3 12 3 eye inflammation 0.0201759636732382 0.151167800111988 1.48664792691497 0.5 12.3 12 3 abnormal thymus cortex morphology 0.0201759636732382 0.151167800111988 1.48664792691497 0.5 12.3 12 3 abnormal bile duct morphology 0.0201759636732382 0.151167800111988 1.48664792691497 0.5 12.3 12 3 decreased cellular sensitivity to gamma-irradiation 0.0201759636732382 0.151167800111988 1.48664792691497 0.5 12.3 12 3 decreased lactate dehydrogenase level 0.0201759636732382 0.151167800111988 1.48664792691497 0.5 12.3 12 3 primary atelectasis 0.0201759636732382 0.151167800111988 1.48664792691497 0.5 12.3 12 3 increased adipocyte glucose uptake 0.0201759636732382 0.151167800111988 1.48664792691497 0.5 12.3 12 3 abnormal antigen presentation 0.0395702415721991 0.247048705264202 1.48664792691497 0.5 12.3 12 3 absent olfactory bulb 0.0395702415721991 0.247048705264202 1.48664792691497 0.5 12.3 12 3 abnormal glucose tolerance 0.0395702415721991 0.247048705264202 1.48664792691497 0.5 12.3 12 3 spina bifida occulta 0.0395702415721991 0.247048705264202 1.48664792691497 0.5 12.3 12 3 decreased compact bone area 0.0395702415721991 0.247048705264202 1.48664792691497 0.5 12.3 12 3 testis degeneration 0.0395702415721991 0.247048705264202 1.48664792691497 0.5 12.3 12 3 multiple persisting craniopharyngeal ducts 0.0395702415721991 0.247048705264202 1.48664792691497 0.5 12.3 12 3 amyloidosis 0.0560053018519602 0.309584863015002 1.48664792691497 0.5 12.3 12 3 mesocardia 0.0560053018519602 0.309584863015002 1.48664792691497 0.5 12.3 12 3 abnormal pilomotor reflex 0.0560053018519602 0.309584863015002 1.48664792691497 0.5 12.3 12 3 myocarditis 0.0560053018519602 0.309584863015002 1.48664792691497 0.5 12.3 12 3 abnormal respiratory function 0.0560053018519602 0.309584863015002 1.48664792691497 0.5 12.3 12 3 increased growth rate 0.0560053018519602 0.309584863015002 1.48664792691497 0.5 12.3 12 3 abnormal gastrocnemius morphology 0.0560053018519602 0.309584863015002 1.48664792691497 0.5 12.3 12 3 abnormal vascular endothelial cell development 0.0560053018519602 0.309584863015002 1.48664792691497 0.5 12.3 12 3 abnormal rostral-caudal body axis extension 0.0560053018519602 0.309584863015002 1.48664792691497 0.5 12.3 12 3 increased hepatocyte proliferation 0.0560053018519602 0.309584863015002 1.48664792691497 0.5 12.3 12 3 decreased keratinocyte proliferation 0.0560053018519602 0.309584863015002 1.48664792691497 0.5 12.3 12 3 oxidative stress 3.47362673499355e-07 1.51145991713831e-05 1.48664792691497 0.5 12.3 12 3 bradykinesia 0.00214863214984941 0.0300755944666712 1.48664792691497 0.5 12.3 12 3 abnormal cell proliferation 0.0145184722435719 0.122422710867407 1.48664792691497 0.5 12.3 12 3 abnormal vascular regression 0.0145184722435719 0.122422710867407 1.48664792691497 0.5 12.3 12 3 anencephaly 0.0145184722435719 0.122422710867407 1.48664792691497 0.5 12.3 12 3 abnormal hair texture 0.0145184722435719 0.122422710867407 1.48664792691497 0.5 12.3 12 3 decreased myocardial infarction size 0.0145184722435719 0.122422710867407 1.48664792691497 0.5 12.3 12 3 abnormal sperm mitochondrial sheath morphology 0.0145184722435719 0.122422710867407 1.48664792691497 0.5 12.3 12 3 absent ductus venosus valve 0.0145184722435719 0.122422710867407 1.48664792691497 0.5 12.3 12 3 decreased mast cell number 0.0281717328592158 0.195201073780778 1.48664792691497 0.5 12.3 12 3 poor circulation 0.0281717328592158 0.195201073780778 1.48664792691497 0.5 12.3 12 3 increased intestinal adenocarcinoma incidence 0.0281717328592158 0.195201073780778 1.48664792691497 0.5 12.3 12 3 abnormal level of surface class II molecules 0.0281717328592158 0.195201073780778 1.48664792691497 0.5 12.3 12 3 blepharitis 0.0281717328592158 0.195201073780778 1.48664792691497 0.5 12.3 12 3 embryonic lethality between somite formation and embryo turning, incomplete penetrance 0.0281717328592158 0.195201073780778 1.48664792691497 0.5 12.3 12 3 retarded hair growth 0.0800744474481402 0.373005970088481 1.48664792691497 0.5 12.3 12 3 increased cranium width 0.0800744474481402 0.373005970088481 1.48664792691497 0.5 12.3 12 3 absent trophoblast giant cells 0.0800744474481402 0.373005970088481 1.48664792691497 0.5 12.3 12 3 decreased incidence of induced tumors 0.0800744474481402 0.373005970088481 1.48664792691497 0.5 12.3 12 3 abnormal airway responsiveness 0.0800744474481402 0.373005970088481 1.48664792691497 0.5 12.3 12 3 ketoaciduria 0.0800744474481402 0.373005970088481 1.48664792691497 0.5 12.3 12 3 abnormal submandibular gland morphology 0.0800744474481402 0.373005970088481 1.48664792691497 0.5 12.3 12 3 abnormal respiratory conducting tube morphology 0.0800744474481402 0.373005970088481 1.48664792691497 0.5 12.3 12 3 abnormal corneal endothelium morphology 0.0800744474481402 0.373005970088481 1.48664792691497 0.5 12.3 12 3 increased serotonin level 0.0800744474481402 0.373005970088481 1.48664792691497 0.5 12.3 12 3 increased circulating fructosamine level 0.0800744474481402 0.373005970088481 1.48664792691497 0.5 12.3 12 3 increased T-helper 17 cell number 0.0800744474481402 0.373005970088481 1.48664792691497 0.5 12.3 12 3 abnormal vibrissa follicle morphology 0.0800744474481402 0.373005970088481 1.48664792691497 0.5 12.3 12 3 fusion of atlas and odontoid process 0.0800744474481402 0.373005970088481 1.48664792691497 0.5 12.3 12 3 abnormal adaptive thermogenesis 0.0800744474481402 0.373005970088481 1.48664792691497 0.5 12.3 12 3 lethality during fetal growth through weaning, complete penetrance 0.0800744474481402 0.373005970088481 1.48664792691497 0.5 12.3 12 3 decreased circulating lactate level 0.0800744474481402 0.373005970088481 1.48664792691497 0.5 12.3 12 3 embryonic lethality, complete penetrance 1.70192898818591e-21 9.40788524024988e-19 1.48198758858608 0.498432601880878 12.3 12 3 decreased cell proliferation 5.38178128924202e-13 6.53033217414123e-11 1.47861199217489 0.497297297297297 12.3 12 3 decreased leukocyte cell number 6.01249874882163e-10 4.4645046679683e-08 1.47579648219296 0.496350364963504 12.3 12 3 abnormal T cell differentiation 1.18905564855019e-07 5.63385890622591e-06 1.47192864050987 0.495049504950495 12.3 12 3 lethality throughout fetal growth and development, complete penetrance 4.4755674695965e-13 5.56648704031065e-11 1.47099900136849 0.494736842105263 12.3 12 3 increased macrophage cell number 8.21527058146776e-05 0.0020435485571401 1.46056638433751 0.491228070175439 12.3 12 3 abnormal platelet physiology 0.000111026166835883 0.00264284775123694 1.45961796460742 0.490909090909091 12.3 12 3 abnormal T-helper 2 physiology 0.000111026166835883 0.00264284775123694 1.45961796460742 0.490909090909091 12.3 12 3 abnormal myocardial trabeculae morphology 0.000505234144292068 0.00924095539651853 1.45361130631686 0.488888888888889 12.3 12 3 abnormal spleen morphology 1.35438756505265e-11 1.3211917913994e-09 1.45247211250313 0.488505747126437 12.3 12 3 arrested B cell differentiation 0.00093126791309787 0.0151407119858232 1.45038822138046 0.48780487804878 12.3 12 3 decreased neutrophil cell number 3.31655408065946e-08 1.71873505742509e-06 1.44852874930176 0.487179487179487 12.3 12 3 increased embryonic tissue cell apoptosis 6.11798135505257e-06 0.00020291304827591 1.44852874930176 0.487179487179487 12.3 12 3 small seminiferous tubules 1.1082065946629e-05 0.000351167376334264 1.44646825321456 0.486486486486487 12.3 12 3 increased trabecular bone volume 0.00172349235293667 0.0249255071391277 1.44646825321456 0.486486486486487 12.3 12 3 abnormal seminiferous tubule morphology 8.07054399994191e-10 5.73585091424443e-08 1.44591784672552 0.486301369863014 12.3 12 3 abnormal dendritic cell physiology 1.43978616641683e-07 6.66159994711743e-06 1.44496620933791 0.485981308411215 12.3 12 3 increased cardiomyocyte apoptosis 0.00320544662812961 0.0414210311037528 1.44159798973573 0.484848484848485 12.3 12 3 embryonic growth arrest 2.17946953562995e-14 4.01587442213297e-12 1.44120454050272 0.48471615720524 12.3 12 3 osteopetrosis 0.00438118838395062 0.0492384473337963 1.43869154217578 0.483870967741935 12.3 12 3 increased lung adenoma incidence 0.00438118838395062 0.0492384473337963 1.43869154217578 0.483870967741935 12.3 12 3 decreased double-negative T cell number 0.00438118838395062 0.0492384473337963 1.43869154217578 0.483870967741935 12.3 12 3 small spleen 1.51761482603848e-06 5.85281686786157e-05 1.43763755569799 0.483516483516484 12.3 12 3 absent mesoderm 8.9542512499859e-05 0.00219445320042758 1.4370929960178 0.483333333333333 12.3 12 3 decreased trophoblast giant cell number 0.00599855606540987 0.0629595283236585 1.43538420529721 0.482758620689655 12.3 12 3 increased susceptibility to induced arthritis 0.00599855606540987 0.0629595283236585 1.43538420529721 0.482758620689655 12.3 12 3 decreased birth body size 8.71024910688478e-08 4.24838130458351e-06 1.43448484176006 0.482456140350877 12.3 12 3 increased neuron apoptosis 6.64803483549714e-06 0.000217591929648673 1.43158689258478 0.481481481481481 12.3 12 3 abnormal cell adhesion 0.000220595484982571 0.00483141341798071 1.43158689258478 0.481481481481481 12.3 12 3 decreased platelet aggregation 0.000220595484982571 0.00483141341798071 1.43158689258478 0.481481481481481 12.3 12 3 abnormal heart valve morphology 0.00822915070041028 0.0807495556894302 1.43158689258478 0.481481481481481 12.3 12 3 abnormal atrioventricular cushion morphology 0.00822915070041028 0.0807495556894302 1.43158689258478 0.481481481481481 12.3 12 3 abnormal fetal cardiomyocyte proliferation 0.00822915070041028 0.0807495556894302 1.43158689258478 0.481481481481481 12.3 12 3 ruffled hair 0.0113146428298983 0.102717036285698 1.42718200983837 0.48 12.3 12 3 increased cellular sensitivity to ionizing radiation 0.0113146428298983 0.102717036285698 1.42718200983837 0.48 12.3 12 3 small heart 0.000546157278793768 0.00984052154488727 1.42470426329351 0.479166666666667 12.3 12 3 abnormal circulating insulin level 0.0155975738355177 0.125672379782582 1.42201106052736 0.478260869565217 12.3 12 3 internal hemorrhage 5.30778174870779e-05 0.00142736292972007 1.42008160182922 0.477611940298507 12.3 12 3 decreased blood urea nitrogen level 0.00100291534922861 0.0160880440291764 1.41907302114611 0.477272727272727 12.3 12 3 increased bone mineral content 3.03558991710246e-07 1.33646547235263e-05 1.41845306788217 0.477064220183486 12.3 12 3 hemorrhage 7.15646818904437e-14 1.01724083544273e-11 1.41706015161257 0.476595744680851 12.3 12 3 decreased susceptibility to hepatic steatosis 9.63420961086378e-05 0.00232670838903142 1.41585516849045 0.476190476190476 12.3 12 3 increased incidence of induced tumors 0.0215672585437972 0.159668320320523 1.41585516849045 0.476190476190476 12.3 12 3 increased acute inflammation 0.0215672585437972 0.159668320320523 1.41585516849045 0.476190476190476 12.3 12 3 increased mean corpuscular hemoglobin 1.31320051524336e-06 5.18505758994899e-05 1.4115646982829 0.474747474747475 12.3 12 3 incomplete embryo turning 0.000236240796864147 0.00510999114956143 1.4084032991826 0.473684210526316 12.3 12 3 decreased neuron apoptosis 0.00251150990172628 0.0343262685744183 1.4084032991826 0.473684210526316 12.3 12 3 abnormal nasal septum morphology 0.0299294381126728 0.205094978802406 1.4084032991826 0.473684210526316 12.3 12 3 increased liver cholesterol level 0.0299294381126728 0.205094978802406 1.4084032991826 0.473684210526316 12.3 12 3 decreased circulating magnesium level 0.0299294381126728 0.205094978802406 1.4084032991826 0.473684210526316 12.3 12 3 increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 0.0299294381126728 0.205094978802406 1.4084032991826 0.473684210526316 12.3 12 3 decreased susceptibility to weight gain 0.0299294381126728 0.205094978802406 1.4084032991826 0.473684210526316 12.3 12 3 embryonic lethality between implantation and somite formation, incomplete penetrance 0.0299294381126728 0.205094978802406 1.4084032991826 0.473684210526316 12.3 12 3 abnormal embryo development 2.69039320100209e-08 1.45485936684624e-06 1.39919804886115 0.470588235294118 12.3 12 3 pericardial edema 7.61900497435066e-05 0.0019240888196647 1.39919804886115 0.470588235294118 12.3 12 3 abnormal direction of heart looping 0.00465575099356777 0.0515865505412019 1.39919804886115 0.470588235294118 12.3 12 3 hyperlipidemia 0.0417144099636818 0.256871556432625 1.39919804886115 0.470588235294118 12.3 12 3 abnormal dorsal-ventral axis patterning 0.0417144099636818 0.256871556432625 1.39919804886115 0.470588235294118 12.3 12 3 abnormal embryonic-extraembryonic boundary morphology 0.0417144099636818 0.256871556432625 1.39919804886115 0.470588235294118 12.3 12 3 increased brain size 0.0417144099636818 0.256871556432625 1.39919804886115 0.470588235294118 12.3 12 3 decreased circulating creatinine level 0.000786007519587629 0.013346032115865 1.39562866608344 0.469387755102041 12.3 12 3 neonatal lethality 0.00635109094345169 0.0659638359993155 1.39373243148278 0.46875 12.3 12 3 abnormal heart atrium morphology 0.00635109094345169 0.0659638359993155 1.39373243148278 0.46875 12.3 12 3 hepatic necrosis 0.00106296469934883 0.0168415585326766 1.39175550604806 0.468085106382979 12.3 12 3 abnormal spermatogenesis 1.87398432165756e-10 1.58018169495701e-08 1.38969262733356 0.467391304347826 12.3 12 3 double outlet right ventricle 1.10859367245399e-06 4.52069960693328e-05 1.38939058590184 0.467289719626168 12.3 12 3 abnormal fat pad morphology 0.0086765382372524 0.0846387798633935 1.38753806512064 0.466666666666667 12.3 12 3 decreased salivation 0.0584498791589176 0.316074074799581 1.38753806512064 0.466666666666667 12.3 12 3 placental labyrinth hypoplasia 0.0584498791589176 0.316074074799581 1.38753806512064 0.466666666666667 12.3 12 3 arthritis 0.0584498791589176 0.316074074799581 1.38753806512064 0.466666666666667 12.3 12 3 abnormal pericyte morphology 0.0584498791589176 0.316074074799581 1.38753806512064 0.466666666666667 12.3 12 3 abnormal trophectoderm morphology 0.0584498791589176 0.316074074799581 1.38753806512064 0.466666666666667 12.3 12 3 abnormal secondary palate development 0.0584498791589176 0.316074074799581 1.38753806512064 0.466666666666667 12.3 12 3 heterochrony 0.0584498791589176 0.316074074799581 1.38753806512064 0.466666666666667 12.3 12 3 abnormal cell migration 0.00143838640354809 0.0212975367787254 1.38753806512064 0.466666666666667 12.3 12 3 seminiferous tubule degeneration 5.98840065558965e-05 0.00159317076265019 1.38482272644134 0.465753424657534 12.3 12 3 dermatitis 0.000336719763628406 0.00667402718745546 1.38412048367945 0.46551724137931 12.3 12 3 straub tail 0.0118730561824435 0.107008069760248 1.38045878927818 0.464285714285714 12.3 12 3 premature aging 0.0118730561824435 0.107008069760248 1.38045878927818 0.464285714285714 12.3 12 3 abnormal mammary gland development 0.0026391734213645 0.0358740103040666 1.37786881031143 0.463414634146341 12.3 12 3 thick ventricular wall 0.0026391734213645 0.0358740103040666 1.37786881031143 0.463414634146341 12.3 12 3 abnormal small intestine morphology 0.000611433566076943 0.0107486996156636 1.3765258582546 0.462962962962963 12.3 12 3 heart inflammation 0.0162775688803879 0.127328467264041 1.37229039407536 0.461538461538462 12.3 12 3 uterus hypoplasia 0.0824480468475072 0.378393941943126 1.37229039407536 0.461538461538462 12.3 12 3 increased pituitary adenoma incidence 0.0824480468475072 0.378393941943126 1.37229039407536 0.461538461538462 12.3 12 3 abnormal tail bud morphology 0.0824480468475072 0.378393941943126 1.37229039407536 0.461538461538462 12.3 12 3 abnormal telomere length 0.0824480468475072 0.378393941943126 1.37229039407536 0.461538461538462 12.3 12 3 small otic vesicle 0.0824480468475072 0.378393941943126 1.37229039407536 0.461538461538462 12.3 12 3 empty decidua capsularis 0.0824480468475072 0.378393941943126 1.37229039407536 0.461538461538462 12.3 12 3 preweaning lethality, incomplete penetrance 4.35279460792405e-20 1.96865028858383e-17 1.36669833867978 0.459657701711491 12.3 12 3 hydrops fetalis 0.000112808830876989 0.00267249492196676 1.36276059967205 0.458333333333333 12.3 12 3 decreased body height 0.0223634769924299 0.164583281120324 1.36276059967205 0.458333333333333 12.3 12 3 increased body temperature 0.0223634769924299 0.164583281120324 1.36276059967205 0.458333333333333 12.3 12 3 abnormal lung saccule morphology 0.0223634769924299 0.164583281120324 1.36276059967205 0.458333333333333 12.3 12 3 decreased circulating thyroxine level 0.00659842142707993 0.0682477060285294 1.35922096175083 0.457142857142857 12.3 12 3 increased red blood cell distribution width 0.00659842142707993 0.0682477060285294 1.35922096175083 0.457142857142857 12.3 12 3 decreased bone mineral content 1.0605537648503e-10 9.25658768443902e-09 1.3579957024704 0.456730769230769 12.3 12 3 abnormal embryo turning 0.000855269832741395 0.0142877708071942 1.35149811537724 0.454545454545455 12.3 12 3 muscular atrophy 0.00273498383013303 0.0368741044848559 1.35149811537724 0.454545454545455 12.3 12 3 decreased macrophage cell number 0.00273498383013303 0.0368741044848559 1.35149811537724 0.454545454545455 12.3 12 3 increased activated T cell number 0.0307997797556186 0.208522385608261 1.35149811537724 0.454545454545455 12.3 12 3 intracerebral hemorrhage 0.0307997797556186 0.208522385608261 1.35149811537724 0.454545454545455 12.3 12 3 abnormal lysosome physiology 0.0307997797556186 0.208522385608261 1.35149811537724 0.454545454545455 12.3 12 3 parakeratosis 0.0307997797556186 0.208522385608261 1.35149811537724 0.454545454545455 12.3 12 3 impaired humoral immune response 0.0307997797556186 0.208522385608261 1.35149811537724 0.454545454545455 12.3 12 3 abnormal thrombopoiesis 0.117307350545492 0.4771905715158 1.35149811537724 0.454545454545455 12.3 12 3 abnormal large intestine morphology 0.117307350545492 0.4771905715158 1.35149811537724 0.454545454545455 12.3 12 3 focal hepatic necrosis 0.117307350545492 0.4771905715158 1.35149811537724 0.454545454545455 12.3 12 3 abnormal proximal-distal axis patterning 0.117307350545492 0.4771905715158 1.35149811537724 0.454545454545455 12.3 12 3 abnormal bronchiole morphology 0.117307350545492 0.4771905715158 1.35149811537724 0.454545454545455 12.3 12 3 impaired luteinization 0.117307350545492 0.4771905715158 1.35149811537724 0.454545454545455 12.3 12 3 abnormal spinal cord ventral horn morphology 0.117307350545492 0.4771905715158 1.35149811537724 0.454545454545455 12.3 12 3 increased glycogen level 0.117307350545492 0.4771905715158 1.35149811537724 0.454545454545455 12.3 12 3 abnormal platelet aggregation 0.117307350545492 0.4771905715158 1.35149811537724 0.454545454545455 12.3 12 3 abnormal palate development 0.117307350545492 0.4771905715158 1.35149811537724 0.454545454545455 12.3 12 3 palatal shelf hypoplasia 0.117307350545492 0.4771905715158 1.35149811537724 0.454545454545455 12.3 12 3 decreased palatine bone horizontal plate size 0.117307350545492 0.4771905715158 1.35149811537724 0.454545454545455 12.3 12 3 abnormal dendritic cell chemotaxis 0.117307350545492 0.4771905715158 1.35149811537724 0.454545454545455 12.3 12 3 abnormal pulmonary alveolar sac morphology 0.117307350545492 0.4771905715158 1.35149811537724 0.454545454545455 12.3 12 3 decreased core body temperature 0.117307350545492 0.4771905715158 1.35149811537724 0.454545454545455 12.3 12 3 reduced sympathetic cervical ganglion size 0.117307350545492 0.4771905715158 1.35149811537724 0.454545454545455 12.3 12 3 abnormal vascular development 0.000271871524418018 0.0055660939669944 1.35149811537724 0.454545454545455 12.3 12 3 decreased brown adipose tissue amount 0.00897246120622005 0.0867842847835905 1.35149811537724 0.454545454545455 12.3 12 3 decreased hemoglobin content 1.446136269927e-07 6.66159994711743e-06 1.34958109677387 0.453900709219858 12.3 12 3 abnormal mesoderm development 0.00115033252673814 0.0180533259322468 1.34639812248903 0.452830188679245 12.3 12 3 increased circulating bilirubin level 0.00115033252673814 0.0180533259322468 1.34639812248903 0.452830188679245 12.3 12 3 atrioventricular septal defect 0.00115033252673814 0.0180533259322468 1.34639812248903 0.452830188679245 12.3 12 3 decreased thymus weight 0.0122138851752657 0.109682452611817 1.34277877269739 0.451612903225806 12.3 12 3 pale kidney 0.0122138851752657 0.109682452611817 1.34277877269739 0.451612903225806 12.3 12 3 increased circulating alkaline phosphatase level 2.90222444889429e-08 1.53601772694139e-06 1.33981850203448 0.450617283950617 12.3 12 3 epidermal hyperplasia 0.000655578929087726 0.0114438777972331 1.33798313422347 0.45 12.3 12 3 increased erythrocyte cell number 0.000655578929087726 0.0114438777972331 1.33798313422347 0.45 12.3 12 3 small gonad 0.0425384101873917 0.258398767621824 1.33798313422347 0.45 12.3 12 3 increased urine glucose level 0.0425384101873917 0.258398767621824 1.33798313422347 0.45 12.3 12 3 brain inflammation 0.0425384101873917 0.258398767621824 1.33798313422347 0.45 12.3 12 3 absent placental labyrinth 0.0425384101873917 0.258398767621824 1.33798313422347 0.45 12.3 12 3 dilated vasculature 0.0425384101873917 0.258398767621824 1.33798313422347 0.45 12.3 12 3 decreased rib number 3.90266344137995e-05 0.00108467880563493 1.33631274329435 0.449438202247191 12.3 12 3 abnormal embryonic tissue morphology 1.54294404625617e-07 6.97831511829497e-06 1.33494915886242 0.448979591836735 12.3 12 3 increased rib number 0.000120425811868833 0.00282973465213765 1.33417121646215 0.448717948717949 12.3 12 3 thrombocytosis 0.00087920156774998 0.0146040512569554 1.3328567620617 0.448275862068966 12.3 12 3 lordosis 0.0166460875275334 0.129542699823244 1.3328567620617 0.448275862068966 12.3 12 3 abnormal pharyngeal arch morphology 0.00914318555561953 0.0879832652595883 1.32146482392442 0.444444444444444 12.3 12 3 cortical renal glomerulopathies 0.0589451669960366 0.31668704730592 1.32146482392442 0.444444444444444 12.3 12 3 thick dermal layer 0.0589451669960366 0.31668704730592 1.32146482392442 0.444444444444444 12.3 12 3 abnormal thymus medulla morphology 0.0589451669960366 0.31668704730592 1.32146482392442 0.444444444444444 12.3 12 3 increased susceptibility to autoimmune disorder 0.0589451669960366 0.31668704730592 1.32146482392442 0.444444444444444 12.3 12 3 jerky movement 0.0589451669960366 0.31668704730592 1.32146482392442 0.444444444444444 12.3 12 3 increased gastrointestinal tumor incidence 0.0589451669960366 0.31668704730592 1.32146482392442 0.444444444444444 12.3 12 3 impaired limb coordination 0.0015814516952671 0.0230724990731784 1.32146482392442 0.444444444444444 12.3 12 3 abnormal eye muscle morphology 0.0227163034243701 0.165642360949966 1.32146482392442 0.444444444444444 12.3 12 3 abnormal nervous system physiology 5.83201744607458e-06 0.000194726757008195 1.31859207430719 0.443478260869565 12.3 12 3 embryonic lethality between somite formation and embryo turning, complete penetrance 0.000382493057238957 0.00740429167223273 1.31674530669611 0.442857142857143 12.3 12 3 distended pericardium 0.00212103488487934 0.0298083292437139 1.31511162765555 0.442307692307692 12.3 12 3 absent corpus luteum 0.00212103488487934 0.0298083292437139 1.31511162765555 0.442307692307692 12.3 12 3 abnormal placenta vasculature 0.00212103488487934 0.0298083292437139 1.31511162765555 0.442307692307692 12.3 12 3 abnormal vasculogenesis 0.00507887400144518 0.0549291264286734 1.3137818889016 0.441860465116279 12.3 12 3 abnormal homeostasis 0.00507887400144518 0.0549291264286734 1.3137818889016 0.441860465116279 12.3 12 3 ventricular septal defect 1.13918345442497e-06 4.60767291525545e-05 1.31174817080733 0.441176470588235 12.3 12 3 abnormal endoderm development 0.0123803903214719 0.110434218533053 1.31174817080733 0.441176470588235 12.3 12 3 short stride length 0.00284468572261972 0.0380438480377234 1.30825017568517 0.44 12.3 12 3 decreased circulating alkaline phosphatase level 0.00284468572261972 0.0380438480377234 1.30825017568517 0.44 12.3 12 3 increased circulating chloride level 0.00284468572261972 0.0380438480377234 1.30825017568517 0.44 12.3 12 3 sparse hair 0.000166890693537045 0.00375692850835656 1.30534939924241 0.439024390243902 12.3 12 3 increased tumor growth/size 0.00683935198291697 0.0698681234394496 1.30534939924241 0.439024390243902 12.3 12 3 decreased caudal vertebrae number 0.000908365247219522 0.0148167773931709 1.3008169360506 0.4375 12.3 12 3 increased sacral vertebrae number 0.000908365247219522 0.0148167773931709 1.3008169360506 0.4375 12.3 12 3 overriding aortic valve 0.00381508820487128 0.0459883716930756 1.3008169360506 0.4375 12.3 12 3 abnormal embryonic hematopoiesis 0.0167738362444543 0.129782014488585 1.3008169360506 0.4375 12.3 12 3 abnormal bone marrow cell number 0.0819995485031302 0.378393941943126 1.3008169360506 0.4375 12.3 12 3 vasculature congestion 0.0819995485031302 0.378393941943126 1.3008169360506 0.4375 12.3 12 3 abnormal mouth morphology 0.0819995485031302 0.378393941943126 1.3008169360506 0.4375 12.3 12 3 increased pancreatic beta cell number 0.0819995485031302 0.378393941943126 1.3008169360506 0.4375 12.3 12 3 small pancreas 0.0819995485031302 0.378393941943126 1.3008169360506 0.4375 12.3 12 3 increased cochlear outer hair cell number 0.0819995485031302 0.378393941943126 1.3008169360506 0.4375 12.3 12 3 abnormal amnion morphology 0.0819995485031302 0.378393941943126 1.3008169360506 0.4375 12.3 12 3 decreased circulating prolactin level 0.0819995485031302 0.378393941943126 1.3008169360506 0.4375 12.3 12 3 decreased midbrain size 0.0819995485031302 0.378393941943126 1.3008169360506 0.4375 12.3 12 3 acanthosis 0.00921164057270096 0.0883004081872587 1.29605203884895 0.435897435897436 12.3 12 3 reduced female fertility 7.71191620276035e-10 5.5604033490917e-08 1.29440897084838 0.435344827586207 12.3 12 3 prenatal lethality, complete penetrance 1.7470041182324e-11 1.67141259388581e-09 1.29413236803389 0.435251798561151 12.3 12 3 abnormal bone structure 1.99581061745385e-08 1.10323975798143e-06 1.29407695192598 0.435233160621762 12.3 12 3 embryonic lethality during organogenesis, incomplete penetrance 1.01582891393232e-09 7.02088348128221e-08 1.29273732775215 0.434782608695652 12.3 12 3 abnormal allantois morphology 0.005116171504549 0.0552124799026708 1.29273732775215 0.434782608695652 12.3 12 3 abnormal B cell morphology 0.0424937843095424 0.258398767621824 1.29273732775215 0.434782608695652 12.3 12 3 abnormal regulatory T cell physiology 0.0424937843095424 0.258398767621824 1.29273732775215 0.434782608695652 12.3 12 3 abnormal vertebral artery topology 0.0424937843095424 0.258398767621824 1.29273732775215 0.434782608695652 12.3 12 3 perinatal lethality, incomplete penetrance 1.76111037842727e-09 1.18398974765887e-07 1.28930528174926 0.433628318584071 12.3 12 3 abnormal spleen marginal zone morphology 0.0227404487495129 0.165642360949966 1.28842820332631 0.433333333333333 12.3 12 3 liver hemorrhage 0.0227404487495129 0.165642360949966 1.28842820332631 0.433333333333333 12.3 12 3 abnormal cellular respiration 0.0227404487495129 0.165642360949966 1.28842820332631 0.433333333333333 12.3 12 3 abnormal branching of the mammary ductal tree 0.0124085885748697 0.110434218533053 1.28574955841295 0.432432432432432 12.3 12 3 abnormal calcium ion homeostasis 0.0124085885748697 0.110434218533053 1.28574955841295 0.432432432432432 12.3 12 3 skin inflammation 0.0124085885748697 0.110434218533053 1.28574955841295 0.432432432432432 12.3 12 3 decreased hematocrit 1.57882068081047e-06 6.042025297717e-05 1.28299752596771 0.431506849315068 12.3 12 3 abnormal trophoblast layer morphology 0.00382875134693279 0.0460097535048083 1.28259821145605 0.431372549019608 12.3 12 3 abnormal spermiogenesis 0.00215214304123316 0.0300755944666712 1.28159304044394 0.431034482758621 12.3 12 3 abnormal placenta morphology 0.000393559041265512 0.00755967656484912 1.2796463168382 0.430379746835443 12.3 12 3 lethargy 0.000128891998511569 0.00298250089579096 1.27883692637847 0.43010752688172 12.3 12 3 disheveled coat 0.00919737360563316 0.0883004081872587 1.2742696516414 0.428571428571429 12.3 12 3 abnormal eye pigmentation 0.0582667739200876 0.316074074799581 1.2742696516414 0.428571428571429 12.3 12 3 trunk curl 0.0582667739200876 0.316074074799581 1.2742696516414 0.428571428571429 12.3 12 3 liver degeneration 0.0582667739200876 0.316074074799581 1.2742696516414 0.428571428571429 12.3 12 3 abnormal clavicle morphology 0.0582667739200876 0.316074074799581 1.2742696516414 0.428571428571429 12.3 12 3 increased muscle cell glucose uptake 0.0582667739200876 0.316074074799581 1.2742696516414 0.428571428571429 12.3 12 3 gliosis 0.00161700421897026 0.0235222104952544 1.2742696516414 0.428571428571429 12.3 12 3 thick pulmonary interalveolar septum 0.0167168669922659 0.129542699823244 1.2742696516414 0.428571428571429 12.3 12 3 increased carcinoma incidence 0.0167168669922659 0.129542699823244 1.2742696516414 0.428571428571429 12.3 12 3 abnormal intestinal goblet cell morphology 0.0167168669922659 0.129542699823244 1.2742696516414 0.428571428571429 12.3 12 3 abnormal hippocampus pyramidal cell morphology 0.0167168669922659 0.129542699823244 1.2742696516414 0.428571428571429 12.3 12 3 small superior cervical ganglion 0.0308487388558151 0.208522385608261 1.2742696516414 0.428571428571429 12.3 12 3 abnormal renal tubule epithelium morphology 0.0308487388558151 0.208522385608261 1.2742696516414 0.428571428571429 12.3 12 3 midline facial cleft 0.114606400803988 0.4771905715158 1.2742696516414 0.428571428571429 12.3 12 3 abnormal spleen periarteriolar lymphoid sheath morphology 0.114606400803988 0.4771905715158 1.2742696516414 0.428571428571429 12.3 12 3 increased lactate dehydrogenase level 0.114606400803988 0.4771905715158 1.2742696516414 0.428571428571429 12.3 12 3 failure of zygotic cell division 0.114606400803988 0.4771905715158 1.2742696516414 0.428571428571429 12.3 12 3 abnormal sagittal suture morphology 0.114606400803988 0.4771905715158 1.2742696516414 0.428571428571429 12.3 12 3 split sternum 0.114606400803988 0.4771905715158 1.2742696516414 0.428571428571429 12.3 12 3 decreased CNS synapse formation 0.114606400803988 0.4771905715158 1.2742696516414 0.428571428571429 12.3 12 3 increased pulmonary respiratory rate 0.114606400803988 0.4771905715158 1.2742696516414 0.428571428571429 12.3 12 3 azoospermia 9.22770566110549e-07 3.82565297199998e-05 1.27159822679519 0.427672955974843 12.3 12 3 abnormal craniofacial morphology 7.41307835544205e-05 0.00190103426898578 1.27014580163609 0.427184466019417 12.3 12 3 abnormal muscle physiology 0.000225130698332777 0.00489093984369243 1.26949710612964 0.426966292134831 12.3 12 3 neurodegeneration 0.00381772814256085 0.0459883716930756 1.26640378959423 0.425925925925926 12.3 12 3 abnormal pancreatic beta cell morphology 0.0123280136235117 0.110434218533053 1.26365073787772 0.425 12.3 12 3 decreased bone mineral density 4.69847245115281e-10 3.59613852992081e-08 1.26309184767963 0.424812030075188 12.3 12 3 abnormal ovarian folliculogenesis 0.0225222178515743 0.165506696915188 1.26139824101876 0.424242424242424 12.3 12 3 abnormal lung development 0.000392380613123485 0.00755967656484912 1.25927824397503 0.423529411764706 12.3 12 3 decreased body length 3.57780340026169e-10 2.87089869617772e-08 1.25876758775282 0.423357664233577 12.3 12 3 ventricular hypoplasia 0.0418739361340419 0.256871556432625 1.25793286123574 0.423076923076923 12.3 12 3 increased susceptibility to otitis media 0.0418739361340419 0.256871556432625 1.25793286123574 0.423076923076923 12.3 12 3 abnormal Mullerian duct morphology 0.0418739361340419 0.256871556432625 1.25793286123574 0.423076923076923 12.3 12 3 pulmonary edema 0.0418739361340419 0.256871556432625 1.25793286123574 0.423076923076923 12.3 12 3 abnormal ectoderm development 0.00911682308720342 0.0878996024396066 1.2553915827282 0.422222222222222 12.3 12 3 decreased total body fat amount 6.2041458114325e-12 6.43033862747431e-10 1.25519375865276 0.422155688622754 12.3 12 3 decreased susceptibility to induced arthritis 0.00378600801298453 0.0458281991839369 1.25191404371787 0.421052631578947 12.3 12 3 persistence of hyaloid vascular system 0.0165193055574902 0.129016554393271 1.25191404371787 0.421052631578947 12.3 12 3 abnormal stationary movement 0.0800475152748469 0.373005970088481 1.25191404371787 0.421052631578947 12.3 12 3 increased malignant tumor incidence 0.0800475152748469 0.373005970088481 1.25191404371787 0.421052631578947 12.3 12 3 increased susceptibility to ischemic brain injury 0.0800475152748469 0.373005970088481 1.25191404371787 0.421052631578947 12.3 12 3 abnormal sternebra morphology 0.0800475152748469 0.373005970088481 1.25191404371787 0.421052631578947 12.3 12 3 abnormal blastocyst morphology 0.0800475152748469 0.373005970088481 1.25191404371787 0.421052631578947 12.3 12 3 decreased liver regeneration 0.0800475152748469 0.373005970088481 1.25191404371787 0.421052631578947 12.3 12 3 shortened RR interval 0.0800475152748469 0.373005970088481 1.25191404371787 0.421052631578947 12.3 12 3 abnormal enzyme/coenzyme activity 2.71872160229637e-06 9.87272990614921e-05 1.24992055001768 0.420382165605096 12.3 12 3 kidney inflammation 0.00675853319919361 0.0692487991435954 1.24878425860857 0.42 12.3 12 3 hypoglycemia 0.000293609403642425 0.00593783245171165 1.24686600321901 0.419354838709677 12.3 12 3 small cranium 0.0303429668864693 0.207642723879209 1.24686600321901 0.419354838709677 12.3 12 3 premature death 1.05477438938537e-27 7.49643226741745e-25 1.24664320932939 0.419279907084785 12.3 12 3 abnormal angiogenesis 0.00119778773278862 0.0185859408957617 1.24556988471254 0.418918918918919 12.3 12 3 edema 1.18957635307436e-06 4.77269544882656e-05 1.24463547369625 0.418604651162791 12.3 12 3 increased oxygen consumption 0.000512938014710354 0.00934749678821981 1.24463547369625 0.418604651162791 12.3 12 3 abnormal rostral-caudal axis patterning 0.00502096677038971 0.0545399774731197 1.24337826614706 0.418181818181818 12.3 12 3 abnormal nervous system morphology 0.00089854539968492 0.0147533444337705 1.24200966046061 0.417721518987342 12.3 12 3 abnormal behavior 1.01608765960265e-09 7.02088348128221e-08 1.24065582390026 0.41726618705036 12.3 12 3 abnormal eye morphology 1.38543600858741e-05 0.000430784008920148 1.24065582390026 0.41726618705036 12.3 12 3 retinal degeneration 0.000290499783954305 0.00592310010316666 1.23887327242914 0.416666666666667 12.3 12 3 intracranial hemorrhage 0.0037371078925084 0.0453466140615348 1.23887327242914 0.416666666666667 12.3 12 3 muscular ventricular septal defect 0.0037371078925084 0.0453466140615348 1.23887327242914 0.416666666666667 12.3 12 3 abnormal osteoclast morphology 0.00898369983186917 0.0867842847835905 1.23887327242914 0.416666666666667 12.3 12 3 ocular hypertelorism 0.0568725752503369 0.313681886774308 1.23887327242914 0.416666666666667 12.3 12 3 increased circulating total protein level 0.0568725752503369 0.313681886774308 1.23887327242914 0.416666666666667 12.3 12 3 abnormal supraoccipital bone morphology 0.161094528183729 0.578660850335057 1.23887327242914 0.416666666666667 12.3 12 3 abnormal mineral level 0.161094528183729 0.578660850335057 1.23887327242914 0.416666666666667 12.3 12 3 absent optic nerve 0.161094528183729 0.578660850335057 1.23887327242914 0.416666666666667 12.3 12 3 abnormal mating frequency 0.161094528183729 0.578660850335057 1.23887327242914 0.416666666666667 12.3 12 3 decreased synaptic depression 0.161094528183729 0.578660850335057 1.23887327242914 0.416666666666667 12.3 12 3 increased fear-related response 0.161094528183729 0.578660850335057 1.23887327242914 0.416666666666667 12.3 12 3 stria vascularis degeneration 0.161094528183729 0.578660850335057 1.23887327242914 0.416666666666667 12.3 12 3 decreased oligodendrocyte number 0.161094528183729 0.578660850335057 1.23887327242914 0.416666666666667 12.3 12 3 increased skeletal muscle glycogen level 0.161094528183729 0.578660850335057 1.23887327242914 0.416666666666667 12.3 12 3 abnormal pulmonary valve cusp morphology 0.161094528183729 0.578660850335057 1.23887327242914 0.416666666666667 12.3 12 3 abnormal colon goblet cell morphology 0.161094528183729 0.578660850335057 1.23887327242914 0.416666666666667 12.3 12 3 abnormal placenta development 0.00665360604208346 0.0686757055173552 1.23419827894828 0.415094339622642 12.3 12 3 abnormal developmental patterning 0.000886517282331767 0.0146040512569554 1.23282998817339 0.414634146341463 12.3 12 3 Leydig cell hyperplasia 0.0162158156189329 0.127045169612899 1.23282998817339 0.414634146341463 12.3 12 3 abnormal circulating glucose level 0.0408741397934256 0.253868720939191 1.23032931882618 0.413793103448276 12.3 12 3 polychromatophilia 0.0408741397934256 0.253868720939191 1.23032931882618 0.413793103448276 12.3 12 3 decreased body weight 9.4743513774942e-37 1.17837245257584e-33 1.2272650899088 0.412762520193861 12.3 12 3 increased circulating aspartate transaminase level 0.00367410343027827 0.0448006484451823 1.22707447935839 0.412698412698413 12.3 12 3 increased insulin sensitivity 1.76469724718849e-05 0.000535327366144068 1.22674444318858 0.412587412587413 12.3 12 3 abnormal adipose tissue morphology 0.110199145480744 0.471402191544885 1.2242982927535 0.411764705882353 12.3 12 3 abnormal interatrial septum morphology 0.110199145480744 0.471402191544885 1.2242982927535 0.411764705882353 12.3 12 3 increased regulatory T cell number 0.110199145480744 0.471402191544885 1.2242982927535 0.411764705882353 12.3 12 3 abnormal ectoplacental cone morphology 0.110199145480744 0.471402191544885 1.2242982927535 0.411764705882353 12.3 12 3 enhanced behavioral response to cocaine 0.110199145480744 0.471402191544885 1.2242982927535 0.411764705882353 12.3 12 3 abnormal cell cytoskeleton morphology 0.110199145480744 0.471402191544885 1.2242982927535 0.411764705882353 12.3 12 3 abnormal immune system physiology 6.96342335088438e-05 0.00180432454013801 1.22288781084941 0.411290322580645 12.3 12 3 abnormal fertility/fecundity 0.00204322311132939 0.0289602136149963 1.22190240568354 0.410958904109589 12.3 12 3 astrocytosis 0.00204322311132939 0.0289602136149963 1.22190240568354 0.410958904109589 12.3 12 3 decreased percent body fat/body weight 0.00204322311132939 0.0289602136149963 1.22190240568354 0.410958904109589 12.3 12 3 increased urine protein level 0.00152696211318496 0.0224752559559029 1.21981368362254 0.41025641025641 12.3 12 3 failure of heart looping 0.0216028985903871 0.159694532670395 1.21981368362254 0.41025641025641 12.3 12 3 teratozoospermia 0.000855830291566605 0.0142877708071942 1.21634830383952 0.409090909090909 12.3 12 3 decreased sensitivity to induced morbidity/mortality 0.0158336290976527 0.125672379782582 1.21634830383952 0.409090909090909 12.3 12 3 lethality, incomplete penetrance 0.0158336290976527 0.125672379782582 1.21634830383952 0.409090909090909 12.3 12 3 abnormal abdominal fat pad morphology 0.0772823852647198 0.370047994891224 1.21634830383952 0.409090909090909 12.3 12 3 abnormal long bone epiphysis morphology 0.0772823852647198 0.370047994891224 1.21634830383952 0.409090909090909 12.3 12 3 abnormal tail movements 0.0772823852647198 0.370047994891224 1.21634830383952 0.409090909090909 12.3 12 3 increased myocardial infarction size 0.0772823852647198 0.370047994891224 1.21634830383952 0.409090909090909 12.3 12 3 decreased circulating estradiol level 0.0772823852647198 0.370047994891224 1.21634830383952 0.409090909090909 12.3 12 3 rough coat 0.0772823852647198 0.370047994891224 1.21634830383952 0.409090909090909 12.3 12 3 increased mammary gland tumor incidence 0.0772823852647198 0.370047994891224 1.21634830383952 0.409090909090909 12.3 12 3 decreased heart weight 0.00149526719514995 0.0220740483557002 1.21134275526405 0.407407407407407 12.3 12 3 abnormal axon morphology 0.000271857694979634 0.0055660939669944 1.21134275526405 0.407407407407407 12.3 12 3 increased brain weight 0.0550448086219412 0.308040408204901 1.21134275526405 0.407407407407407 12.3 12 3 increased thermal nociceptive threshold 0.000837865207093262 0.0141570511685964 1.20892249001877 0.406593406593407 12.3 12 3 decreased circulating LDL cholesterol level 0.00472777688910418 0.0521523060383443 1.20790144061841 0.40625 12.3 12 3 scoliosis 0.0396271089046901 0.247048705264202 1.20790144061841 0.40625 12.3 12 3 failure of primitive streak formation 0.0396271089046901 0.247048705264202 1.20790144061841 0.40625 12.3 12 3 decreased spleen weight 0.00351611186025275 0.0445105763479832 1.20655483923534 0.405797101449275 12.3 12 3 perimembraneous ventricular septal defect 0.00351611186025275 0.0445105763479832 1.20655483923534 0.405797101449275 12.3 12 3 male infertility 1.83966284105726e-14 3.66092905370394e-12 1.20586949141413 0.405566600397614 12.3 12 3 increased circulating phosphate level 0.0287525832234746 0.198672363245536 1.20539021101214 0.405405405405405 12.3 12 3 abnormal chromosome morphology 0.0287525832234746 0.198672363245536 1.20539021101214 0.405405405405405 12.3 12 3 abnormal somite development 0.0019548203010999 0.0279460660861264 1.20437300408301 0.40506329113924 12.3 12 3 abnormal myocardium layer morphology 0.0019548203010999 0.0279460660861264 1.20437300408301 0.40506329113924 12.3 12 3 neuron degeneration 0.0153941575165258 0.125672379782582 1.20197066431423 0.404255319148936 12.3 12 3 decreased bone trabecula number 0.0153941575165258 0.125672379782582 1.20197066431423 0.404255319148936 12.3 12 3 decreased IgA level 0.0113350056122308 0.102717036285698 1.20075409481594 0.403846153846154 12.3 12 3 abnormal renal glomerulus morphology 0.000345864010181404 0.00680108083261852 1.20022951897722 0.403669724770642 12.3 12 3 decreased brain weight 0.00837313287899701 0.0818395600648529 1.19975095856296 0.403508771929825 12.3 12 3 prenatal lethality 0.00620204035884799 0.0646858507028695 1.19890961847981 0.403225806451613 12.3 12 3 pericardial effusion 0.00620204035884799 0.0646858507028695 1.19890961847981 0.403225806451613 12.3 12 3 reduced fertility 6.28996493630091e-05 0.00164697766095248 1.19787458859336 0.402877697841727 12.3 12 3 abnormal forebrain development 0.00342542598430594 0.0436961391587745 1.1975774966815 0.402777777777778 12.3 12 3 small testis 2.60213244103609e-08 1.42259438397303e-06 1.19578202817074 0.402173913043478 12.3 12 3 insulin resistance 0.000108082075480234 0.002597624760938 1.1938233352499 0.401515151515151 12.3 12 3 abnormal neural tube morphology 1.9891822652129e-05 0.000596155528279168 1.19298907715399 0.401234567901235 12.3 12 3 abnormal glucose homeostasis 6.48028044640238e-06 0.000213505928614913 1.19258569961311 0.401098901098901 12.3 12 3 abnormal blood vessel morphology 5.98197937579422e-05 0.00159317076265019 1.18931834153197 0.4 12.3 12 3 abnormal liver physiology 0.00077694497191141 0.0132373329974632 1.18931834153197 0.4 12.3 12 3 abnormal neurocranium morphology 0.00332931646848563 0.0425793044491414 1.18931834153197 0.4 12.3 12 3 domed cranium 0.00447338556770214 0.0497876805353873 1.18931834153197 0.4 12.3 12 3 thick epidermis 0.00447338556770214 0.0497876805353873 1.18931834153197 0.4 12.3 12 3 decreased monocyte cell number 0.00602220564506496 0.0630746801772594 1.18931834153197 0.4 12.3 12 3 testicular atrophy 0.0149142506592123 0.123870445792289 1.18931834153197 0.4 12.3 12 3 abnormal embryonic epiblast morphology 0.0382245838762327 0.24292221488695 1.18931834153197 0.4 12.3 12 3 holoprosencephaly 0.0382245838762327 0.24292221488695 1.18931834153197 0.4 12.3 12 3 decreased triglyceride level 0.0382245838762327 0.24292221488695 1.18931834153197 0.4 12.3 12 3 gastrointestinal hemorrhage 0.0529632671560341 0.297395320656061 1.18931834153197 0.4 12.3 12 3 abnormal microglial cell physiology 0.0529632671560341 0.297395320656061 1.18931834153197 0.4 12.3 12 3 abnormal fontanelle morphology 0.152044081900702 0.574253747042547 1.18931834153197 0.4 12.3 12 3 abnormal enteric neuron morphology 0.152044081900702 0.574253747042547 1.18931834153197 0.4 12.3 12 3 abnormal pup retrieval 0.152044081900702 0.574253747042547 1.18931834153197 0.4 12.3 12 3 no suckling reflex 0.152044081900702 0.574253747042547 1.18931834153197 0.4 12.3 12 3 absent egg cylinders 0.152044081900702 0.574253747042547 1.18931834153197 0.4 12.3 12 3 increased airway responsiveness 0.152044081900702 0.574253747042547 1.18931834153197 0.4 12.3 12 3 joint inflammation 0.152044081900702 0.574253747042547 1.18931834153197 0.4 12.3 12 3 abnormal olfactory nerve morphology 0.152044081900702 0.574253747042547 1.18931834153197 0.4 12.3 12 3 abnormal cerebral aqueduct morphology 0.152044081900702 0.574253747042547 1.18931834153197 0.4 12.3 12 3 abnormal coronary vessel morphology 0.152044081900702 0.574253747042547 1.18931834153197 0.4 12.3 12 3 decreased trabecular bone mass 0.152044081900702 0.574253747042547 1.18931834153197 0.4 12.3 12 3 thin ventricular wall 0.00138539136112403 0.0207890599262393 1.18931834153197 0.4 12.3 12 3 increased susceptibility to parasitic infection 0.00138539136112403 0.0207890599262393 1.18931834153197 0.4 12.3 12 3 albuminuria 0.0203114997712856 0.151283688000655 1.18931834153197 0.4 12.3 12 3 abnormal female reproductive system morphology 0.0277861552349706 0.195201073780778 1.18931834153197 0.4 12.3 12 3 abnormal circulating enzyme level 0.10505358533315 0.453872151237091 1.18931834153197 0.4 12.3 12 3 abnormal heart right ventricle morphology 0.10505358533315 0.453872151237091 1.18931834153197 0.4 12.3 12 3 abnormal response to tactile stimuli 0.10505358533315 0.453872151237091 1.18931834153197 0.4 12.3 12 3 abnormal circulating cytokine level 0.10505358533315 0.453872151237091 1.18931834153197 0.4 12.3 12 3 abnormal heart development 3.31418333212139e-05 0.000931528930921126 1.18555467589422 0.39873417721519 12.3 12 3 increased bone mineral density 0.000425300639190489 0.00789503985064433 1.18405587099422 0.398230088495575 12.3 12 3 prenatal lethality, incomplete penetrance 1.2854555420384e-08 7.43621083911747e-07 1.18344999445205 0.398026315789474 12.3 12 3 increased circulating alanine transaminase level 0.00322924120430622 0.0416204015321851 1.18169450600933 0.397435897435897 12.3 12 3 skin lesions 0.00786515675922289 0.0777915603919163 1.17987930707537 0.396825396825397 12.3 12 3 abnormal coat/ hair morphology 0.0144071740801398 0.122422710867407 1.1780983571779 0.39622641509434 12.3 12 3 postnatal growth retardation 2.23389312867925e-15 5.29219919770441e-13 1.17571502716805 0.395424836601307 12.3 12 3 kidney failure 0.0267589819089222 0.19099847201849 1.17548905849091 0.395348837209302 12.3 12 3 decreased circulating glucose level 1.02530416278396e-07 4.95231865034e-06 1.1722671825136 0.39426523297491 12.3 12 3 cachexia 0.000946778241551031 0.0153427418622683 1.17216471160603 0.394230769230769 12.3 12 3 abnormal QRS complex 0.0507452880892153 0.291078233348796 1.17129836666028 0.393939393939394 12.3 12 3 diarrhea 0.0507452880892153 0.291078233348796 1.17129836666028 0.393939393939394 12.3 12 3 decreased body size 3.53330609127997e-19 1.25558555743699e-16 1.16994348133158 0.393483709273183 12.3 12 3 increased osteoclast cell number 0.0102561315461916 0.0966826036829465 1.16982131953965 0.39344262295082 12.3 12 3 kyphosis 9.10143594547048e-05 0.00221959038376057 1.16949636917311 0.393333333333333 12.3 12 3 arrest of spermatogenesis 0.00302196787770238 0.0394033154863467 1.16808051400462 0.392857142857143 12.3 12 3 abnormal jaw morphology 0.0707010890588464 0.348255364423525 1.16808051400462 0.392857142857143 12.3 12 3 reddish skin 0.0707010890588464 0.348255364423525 1.16808051400462 0.392857142857143 12.3 12 3 abnormal somite shape 0.0707010890588464 0.348255364423525 1.16808051400462 0.392857142857143 12.3 12 3 hypoxia 0.0707010890588464 0.348255364423525 1.16808051400462 0.392857142857143 12.3 12 3 abnormal placenta labyrinth morphology 0.00405230470429361 0.0475476790185394 1.16673634770542 0.392405063291139 12.3 12 3 microphthalmia 8.81429542560975e-05 0.00218164774837853 1.16599837405096 0.392156862745098 12.3 12 3 reduced male fertility 2.1086616038628e-06 7.88766276632891e-05 1.16574154621526 0.392070484581498 12.3 12 3 abnormal testis morphology 0.000664655924771079 0.0115617595305459 1.16346359497693 0.391304347826087 12.3 12 3 abnormal locomotor behavior 0.00217979559166236 0.0303767032731659 1.16346359497693 0.391304347826087 12.3 12 3 hyperkeratosis 0.00732394893764664 0.0740582235056749 1.16346359497693 0.391304347826087 12.3 12 3 abnormal cranial nerve morphology 0.0996464858787625 0.448228993894072 1.16346359497693 0.391304347826087 12.3 12 3 conjunctivitis 0.0996464858787625 0.448228993894072 1.16346359497693 0.391304347826087 12.3 12 3 pancreas inflammation 0.0996464858787625 0.448228993894072 1.16346359497693 0.391304347826087 12.3 12 3 increased susceptibility to fungal infection 0.0996464858787625 0.448228993894072 1.16346359497693 0.391304347826087 12.3 12 3 abnormal liver morphology 2.68330556875926e-05 0.000771644231478458 1.16274139535249 0.391061452513966 12.3 12 3 increased sensitivity to xenobiotic induced morbidity/mortality 0.00088524413192885 0.0146040512569554 1.16228837922443 0.390909090909091 12.3 12 3 lethality at weaning, incomplete penetrance 0.0351911725892348 0.233541040534887 1.16031057710437 0.390243902439024 12.3 12 3 abnormal heart morphology 2.52510993641116e-06 9.23707495120995e-05 1.15842695603764 0.38961038961039 12.3 12 3 cochlear outer hair cell degeneration 0.00704928993587115 0.0717182360551308 1.15628172093386 0.388888888888889 12.3 12 3 abnormal neuronal precursor proliferation 0.0181005662505892 0.138752414632791 1.15628172093386 0.388888888888889 12.3 12 3 axon degeneration 0.0181005662505892 0.138752414632791 1.15628172093386 0.388888888888889 12.3 12 3 reduced long term depression 0.0484687303311905 0.290170798312482 1.15628172093386 0.388888888888889 12.3 12 3 abnormal mammary gland morphology 0.142815313607376 0.564341688003729 1.15628172093386 0.388888888888889 12.3 12 3 abnormal retinal rod cell morphology 0.142815313607376 0.564341688003729 1.15628172093386 0.388888888888889 12.3 12 3 abnormal white adipose tissue morphology 0.142815313607376 0.564341688003729 1.15628172093386 0.388888888888889 12.3 12 3 acidosis 0.142815313607376 0.564341688003729 1.15628172093386 0.388888888888889 12.3 12 3 decreased activity of thyroid 0.142815313607376 0.564341688003729 1.15628172093386 0.388888888888889 12.3 12 3 darkened coat color 0.142815313607376 0.564341688003729 1.15628172093386 0.388888888888889 12.3 12 3 atrioventricular block 0.142815313607376 0.564341688003729 1.15628172093386 0.388888888888889 12.3 12 3 weight loss 4.39119929656777e-05 0.00119378232242758 1.1553378174882 0.388571428571429 12.3 12 3 increased heart weight 0.000254909647755867 0.00528406457327266 1.15509335328645 0.388489208633094 12.3 12 3 abnormal craniofacial development 0.024624140172828 0.178318919009926 1.15291063719936 0.387755102040816 12.3 12 3 increased eosinophil cell number 0.0128166101908297 0.113558211157204 1.15095323374062 0.387096774193548 12.3 12 3 abnormal eyelid morphology 0.0672497725894434 0.334567618632481 1.15095323374062 0.387096774193548 12.3 12 3 abnormal object recognition memory 0.0672497725894434 0.334567618632481 1.15095323374062 0.387096774193548 12.3 12 3 abnormal capillary morphology 0.0672497725894434 0.334567618632481 1.15095323374062 0.387096774193548 12.3 12 3 osteoporosis 0.0336379077530548 0.22544954792418 1.14877339807066 0.386363636363636 12.3 12 3 renal interstitial fibrosis 0.0336379077530548 0.22544954792418 1.14877339807066 0.386363636363636 12.3 12 3 ataxia 1.64901896558629e-05 0.000503304868330785 1.1481043395977 0.386138613861386 12.3 12 3 abnormal facial morphology 0.0173469440608814 0.134007836495163 1.14758787340805 0.385964912280702 12.3 12 3 perinatal lethality, complete penetrance 1.16096721323372e-05 0.000365557714293528 1.14464910804721 0.384976525821596 12.3 12 3 abnormal lipid homeostasis 0.000553701608179939 0.00984052154488727 1.14357532839613 0.384615384615385 12.3 12 3 abnormal snout morphology 0.0235515459204039 0.17104954883797 1.14357532839613 0.384615384615385 12.3 12 3 abnormal skin condition 0.0235515459204039 0.17104954883797 1.14357532839613 0.384615384615385 12.3 12 3 abnormal nasal bone morphology 0.0942269187319326 0.426938907733483 1.14357532839613 0.384615384615385 12.3 12 3 decreased circulating glycerol level 0.0942269187319326 0.426938907733483 1.14357532839613 0.384615384615385 12.3 12 3 abnormal erythrocyte osmotic lysis 0.0942269187319326 0.426938907733483 1.14357532839613 0.384615384615385 12.3 12 3 absent myocardial trabeculae 0.210248579018869 0.649946720304317 1.14357532839613 0.384615384615385 12.3 12 3 absent trabeculae carneae 0.210248579018869 0.649946720304317 1.14357532839613 0.384615384615385 12.3 12 3 short hair 0.210248579018869 0.649946720304317 1.14357532839613 0.384615384615385 12.3 12 3 abnormal digestion 0.210248579018869 0.649946720304317 1.14357532839613 0.384615384615385 12.3 12 3 abnormal soleus morphology 0.210248579018869 0.649946720304317 1.14357532839613 0.384615384615385 12.3 12 3 abnormal insulin secretion 0.210248579018869 0.649946720304317 1.14357532839613 0.384615384615385 12.3 12 3 increased cochlear inner hair cell number 0.210248579018869 0.649946720304317 1.14357532839613 0.384615384615385 12.3 12 3 abnormal exocrine pancreas morphology 0.210248579018869 0.649946720304317 1.14357532839613 0.384615384615385 12.3 12 3 abnormal vertebral arch development 0.210248579018869 0.649946720304317 1.14357532839613 0.384615384615385 12.3 12 3 increased circulating ammonia level 0.210248579018869 0.649946720304317 1.14357532839613 0.384615384615385 12.3 12 3 small pituitary gland 0.210248579018869 0.649946720304317 1.14357532839613 0.384615384615385 12.3 12 3 increased prostaglandin level 0.210248579018869 0.649946720304317 1.14357532839613 0.384615384615385 12.3 12 3 abnormal aorta tunica media morphology 0.210248579018869 0.649946720304317 1.14357532839613 0.384615384615385 12.3 12 3 abnormal hair follicle inner root sheath morphology 0.210248579018869 0.649946720304317 1.14357532839613 0.384615384615385 12.3 12 3 abnormal response to injury 0.0461857510369099 0.277504965469356 1.14357532839613 0.384615384615385 12.3 12 3 decreased trabecular bone volume 0.0461857510369099 0.277504965469356 1.14357532839613 0.384615384615385 12.3 12 3 increased respiratory quotient 0.0320939083044449 0.21605844900489 1.13870905040295 0.382978723404255 12.3 12 3 decreased circulating cholesterol level 6.1533434637652e-05 0.00162834487937404 1.13732628288577 0.382513661202186 12.3 12 3 abnormal reproductive system morphology 0.0439313672977011 0.265563247030453 1.13268413479236 0.380952380952381 12.3 12 3 spina bifida 0.0439313672977011 0.265563247030453 1.13268413479236 0.380952380952381 12.3 12 3 left pulmonary isomerism 0.13384546927965 0.535274284297635 1.13268413479236 0.380952380952381 12.3 12 3 vascular ring 0.13384546927965 0.535274284297635 1.13268413479236 0.380952380952381 12.3 12 3 abnormal ovary morphology 0.0112455047808689 0.102465908946561 1.13068997258322 0.380281690140845 12.3 12 3 corneal opacity 0.0112455047808689 0.102465908946561 1.13068997258322 0.380281690140845 12.3 12 3 abnormal interventricular septum morphology 0.0305753627779474 0.208522385608261 1.12985242445538 0.38 12.3 12 3 decreased respiratory quotient 0.0305753627779474 0.208522385608261 1.12985242445538 0.38 12.3 12 3 abnormal spinal nerve morphology 0.0889286691654923 0.404775964408348 1.12780187559067 0.379310344827586 12.3 12 3 enlarged epididymis 0.0889286691654923 0.404775964408348 1.12780187559067 0.379310344827586 12.3 12 3 abnormal brain morphology 0.000238170494149382 0.00512942947356352 1.12652824275544 0.37888198757764 12.3 12 3 abnormal skin morphology 0.0151437941948075 0.124963639058146 1.12624842948104 0.378787878787879 12.3 12 3 abnormal long bone metaphysis morphology 0.0604698633532785 0.317401343012133 1.12503086361133 0.378378378378378 12.3 12 3 abnormal vocalization 0.0604698633532785 0.317401343012133 1.12503086361133 0.378378378378378 12.3 12 3 decreased width of hypertrophic chondrocyte zone 0.0604698633532785 0.317401343012133 1.12503086361133 0.378378378378378 12.3 12 3 abnormal pancreatic beta cell physiology 0.0604698633532785 0.317401343012133 1.12503086361133 0.378378378378378 12.3 12 3 altered response to myocardial infarction 0.0417289411705575 0.256871556432625 1.12324510033575 0.377777777777778 12.3 12 3 lethality at weaning, complete penetrance 0.0417289411705575 0.256871556432625 1.12324510033575 0.377777777777778 12.3 12 3 increased or absent threshold for auditory brainstem response 1.50239197017093e-06 5.8393750403128e-05 1.12141608327842 0.377162629757785 12.3 12 3 abnormal heart left ventricle morphology 0.0137632336878675 0.117649635046634 1.11498594518623 0.375 12.3 12 3 abnormal depression-related behavior 0.0838233708002952 0.383644222384056 1.11498594518623 0.375 12.3 12 3 increased fatty acid level 0.0838233708002952 0.383644222384056 1.11498594518623 0.375 12.3 12 3 abnormal auditory brainstem response waveform shape 0.0838233708002952 0.383644222384056 1.11498594518623 0.375 12.3 12 3 abnormal startle reflex 0.125310832255818 0.503978488660221 1.11498594518623 0.375 12.3 12 3 abnormal primitive streak formation 0.125310832255818 0.503978488660221 1.11498594518623 0.375 12.3 12 3 abnormal retinal ganglion layer morphology 0.125310832255818 0.503978488660221 1.11498594518623 0.375 12.3 12 3 abnormal truncus arteriosus septation 0.125310832255818 0.503978488660221 1.11498594518623 0.375 12.3 12 3 failure of tooth eruption 0.194070801939245 0.649295386447709 1.11498594518623 0.375 12.3 12 3 abnormal hair follicle orientation 0.194070801939245 0.649295386447709 1.11498594518623 0.375 12.3 12 3 mixed cellular infiltration to dermis 0.194070801939245 0.649295386447709 1.11498594518623 0.375 12.3 12 3 disorganized yolk sac vascular plexus 0.194070801939245 0.649295386447709 1.11498594518623 0.375 12.3 12 3 abnormal extraembryonic endoderm formation 0.194070801939245 0.649295386447709 1.11498594518623 0.375 12.3 12 3 abnormal olfaction 0.194070801939245 0.649295386447709 1.11498594518623 0.375 12.3 12 3 abnormal pulmonary elastic fiber morphology 0.194070801939245 0.649295386447709 1.11498594518623 0.375 12.3 12 3 small epididymis 0.194070801939245 0.649295386447709 1.11498594518623 0.375 12.3 12 3 increased thymus weight 0.194070801939245 0.649295386447709 1.11498594518623 0.375 12.3 12 3 dystonia 0.194070801939245 0.649295386447709 1.11498594518623 0.375 12.3 12 3 abnormal Langerhans cell physiology 0.194070801939245 0.649295386447709 1.11498594518623 0.375 12.3 12 3 kidney degeneration 0.194070801939245 0.649295386447709 1.11498594518623 0.375 12.3 12 3 abnormal pulmonary alveolus wall morphology 0.194070801939245 0.649295386447709 1.11498594518623 0.375 12.3 12 3 perinatal lethality 0.0572255085180735 0.314930204510416 1.11498594518623 0.375 12.3 12 3 decreased white adipose tissue amount 0.0185065284209759 0.141428539008226 1.10943875142908 0.373134328358209 12.3 12 3 increased hemoglobin content 0.0262687347591537 0.18776861411895 1.10868658956371 0.372881355932203 12.3 12 3 abnormal gastrulation 0.0375355889632595 0.24292221488695 1.10769845534841 0.372549019607843 12.3 12 3 small lung 0.0375355889632595 0.24292221488695 1.10769845534841 0.372549019607843 12.3 12 3 cochlear inner hair cell degeneration 0.0375355889632595 0.24292221488695 1.10769845534841 0.372549019607843 12.3 12 3 increased circulating creatinine level 0.0088787625826431 0.0861049587692972 1.10634264328556 0.372093023255814 12.3 12 3 abnormal organ of Corti morphology 0.0541075956762371 0.303136586136576 1.10634264328556 0.372093023255814 12.3 12 3 abnormal intestinal mucosa morphology 0.0541075956762371 0.303136586136576 1.10634264328556 0.372093023255814 12.3 12 3 abnormal cornea morphology 0.0124729223715652 0.110808551425959 1.10545615078293 0.371794871794872 12.3 12 3 impaired adaptive thermogenesis 0.0789476195609324 0.373005970088481 1.10436703142255 0.371428571428571 12.3 12 3 impaired glucose tolerance 2.00612354905201e-05 0.000597632614163699 1.10299684900143 0.370967741935484 12.3 12 3 increased exploration in new environment 0.0118638053550147 0.107008069760248 1.10122068660368 0.37037037037037 12.3 12 3 increased cell proliferation 0.0355600737007629 0.234319690942113 1.10122068660368 0.37037037037037 12.3 12 3 abnormal trigeminal ganglion morphology 0.117275218796633 0.4771905715158 1.10122068660368 0.37037037037037 12.3 12 3 abnormal type II pneumocyte morphology 0.117275218796633 0.4771905715158 1.10122068660368 0.37037037037037 12.3 12 3 abnormal skin appearance 0.117275218796633 0.4771905715158 1.10122068660368 0.37037037037037 12.3 12 3 thick interventricular septum 0.117275218796633 0.4771905715158 1.10122068660368 0.37037037037037 12.3 12 3 abnormal bone trabecula morphology 0.117275218796633 0.4771905715158 1.10122068660368 0.37037037037037 12.3 12 3 enlarged liver 0.00575431986256643 0.0607807671258344 1.10011946591708 0.37 12.3 12 3 atrial septal defect 0.0511262375763733 0.291078233348796 1.09882672858932 0.369565217391304 12.3 12 3 abnormal craniofacial bone morphology 0.0336701535894806 0.22544954792418 1.09542478825313 0.368421052631579 12.3 12 3 shiny skin 0.179429862634685 0.610159649082404 1.09542478825313 0.368421052631579 12.3 12 3 short vibrissae 0.179429862634685 0.610159649082404 1.09542478825313 0.368421052631579 12.3 12 3 abnormal long term depression 0.179429862634685 0.610159649082404 1.09542478825313 0.368421052631579 12.3 12 3 oliguria 0.179429862634685 0.610159649082404 1.09542478825313 0.368421052631579 12.3 12 3 Leydig cell hypoplasia 0.179429862634685 0.610159649082404 1.09542478825313 0.368421052631579 12.3 12 3 decreased fertilization frequency 0.179429862634685 0.610159649082404 1.09542478825313 0.368421052631579 12.3 12 3 postnatal lethality 0.000606740296875503 0.0107040176487788 1.09259666917847 0.367469879518072 12.3 12 3 abnormal respiratory system physiology 0.0482858380306238 0.28942414964139 1.09223112997834 0.36734693877551 12.3 12 3 no abnormal phenotype detected 4.75596097537179e-28 3.94348430874578e-25 1.09163657572892 0.367146974063401 12.3 12 3 hunched posture 0.0150647614238031 0.124704139905858 1.09146303495023 0.367088607594937 12.3 12 3 abnormal visceral yolk sac morphology 0.0150647614238031 0.124704139905858 1.09146303495023 0.367088607594937 12.3 12 3 abnormal optic cup morphology 0.109750744013074 0.471402191544885 1.09020847973764 0.366666666666667 12.3 12 3 postnatal lethality, incomplete penetrance 7.1615767005142e-10 5.23953589486149e-08 1.08881256619124 0.366197183098592 12.3 12 3 abnormal coat/hair pigmentation 0.00471695052424987 0.0521485085736514 1.08843866077703 0.366071428571429 12.3 12 3 scaly skin 0.0699376254000958 0.346208643149728 1.08779116603534 0.365853658536585 12.3 12 3 liver fibrosis 0.0699376254000958 0.346208643149728 1.08779116603534 0.365853658536585 12.3 12 3 palatal shelves fail to meet at midline 0.0699376254000958 0.346208643149728 1.08779116603534 0.365853658536585 12.3 12 3 eyelids open at birth 0.0455870076849035 0.274570657666337 1.08639656197632 0.365384615384615 12.3 12 3 abnormal brain wave pattern 0.0455870076849035 0.274570657666337 1.08639656197632 0.365384615384615 12.3 12 3 decreased grip strength 0.000121152458473431 0.00282973465213765 1.0861354717187 0.365296803652968 12.3 12 3 abnormal neuron morphology 0.0087137298572303 0.0848352368683381 1.0811984923018 0.363636363636364 12.3 12 3 abnormal learning/memory/conditioning 0.0430278443005657 0.260735110103915 1.0811984923018 0.363636363636364 12.3 12 3 omphalocele 0.0658045602037696 0.328362775339773 1.0811984923018 0.363636363636364 12.3 12 3 embryonic lethality, incomplete penetrance 0.0658045602037696 0.328362775339773 1.0811984923018 0.363636363636364 12.3 12 3 abnormal locomotor coordination 0.102725132349484 0.453872151237091 1.0811984923018 0.363636363636364 12.3 12 3 increased osteoblast cell number 0.102725132349484 0.453872151237091 1.0811984923018 0.363636363636364 12.3 12 3 abnormal enterocyte morphology 0.166167231573896 0.589204555901094 1.0811984923018 0.363636363636364 12.3 12 3 intestinal ulcer 0.166167231573896 0.589204555901094 1.0811984923018 0.363636363636364 12.3 12 3 abnormal facial nerve morphology 0.166167231573896 0.589204555901094 1.0811984923018 0.363636363636364 12.3 12 3 abnormal oogenesis 0.166167231573896 0.589204555901094 1.0811984923018 0.363636363636364 12.3 12 3 aphakia 0.166167231573896 0.589204555901094 1.0811984923018 0.363636363636364 12.3 12 3 prolonged PR interval 0.166167231573896 0.589204555901094 1.0811984923018 0.363636363636364 12.3 12 3 pulmonary vascular congestion 0.166167231573896 0.589204555901094 1.0811984923018 0.363636363636364 12.3 12 3 increased circulating creatine kinase level 0.166167231573896 0.589204555901094 1.0811984923018 0.363636363636364 12.3 12 3 impaired balance 0.00826874791491064 0.0809783875525206 1.07854849599713 0.362745098039216 12.3 12 3 abnormal sternum morphology 0.0269660608329401 0.192200791753405 1.07728110646012 0.36231884057971 12.3 12 3 increased circulating HDL cholesterol level 0.0078449035138085 0.0777915603919163 1.07604992805274 0.361904761904762 12.3 12 3 narrow eye opening 0.0961748178212218 0.434972471509617 1.07369016943859 0.361111111111111 12.3 12 3 abnormal retinal blood vessel morphology 0.0961748178212218 0.434972471509617 1.07369016943859 0.361111111111111 12.3 12 3 abnormal male meiosis 0.0383132793564393 0.24292221488695 1.07233620957801 0.360655737704918 12.3 12 3 delayed bone ossification 0.0241014152183372 0.174787960220449 1.07038650737878 0.36 12.3 12 3 abnormal circulating protein level 0.0582479803602542 0.316074074799581 1.07038650737878 0.36 12.3 12 3 abnormal primitive streak morphology 0.154121900040432 0.574253747042547 1.07038650737878 0.36 12.3 12 3 decreased acute inflammation 0.154121900040432 0.574253747042547 1.07038650737878 0.36 12.3 12 3 decreased circulating HDL cholesterol level 0.00433740351350256 0.0492384473337963 1.06852819747013 0.359375 12.3 12 3 increased blood urea nitrogen level 0.00267876329111893 0.0363129356221163 1.06628540964936 0.358620689655172 12.3 12 3 decreased anxiety-related response 0.00570284538140208 0.0604024460299576 1.06361802901234 0.357723577235772 12.3 12 3 skin edema 0.0843855465680929 0.385507891805567 1.06189137636783 0.357142857142857 12.3 12 3 failure of blastocyst to hatch from the zona pellucida 0.143149735317626 0.564766005713869 1.06189137636783 0.357142857142857 12.3 12 3 corneal vascularization 0.143149735317626 0.564766005713869 1.06189137636783 0.357142857142857 12.3 12 3 abnormal blood flow velocity 0.26338312247158 0.649946720304317 1.06189137636783 0.357142857142857 12.3 12 3 abnormal placing response 0.26338312247158 0.649946720304317 1.06189137636783 0.357142857142857 12.3 12 3 abnormal fluid regulation 0.26338312247158 0.649946720304317 1.06189137636783 0.357142857142857 12.3 12 3 absent otoliths 0.26338312247158 0.649946720304317 1.06189137636783 0.357142857142857 12.3 12 3 abnormal ventral body wall morphology 0.26338312247158 0.649946720304317 1.06189137636783 0.357142857142857 12.3 12 3 abnormal pancreas development 0.26338312247158 0.649946720304317 1.06189137636783 0.357142857142857 12.3 12 3 abnormal viscerocranium morphology 0.26338312247158 0.649946720304317 1.06189137636783 0.357142857142857 12.3 12 3 sternebra fusion 0.26338312247158 0.649946720304317 1.06189137636783 0.357142857142857 12.3 12 3 increased lung compliance 0.26338312247158 0.649946720304317 1.06189137636783 0.357142857142857 12.3 12 3 pulmonary alveolar hemorrhage 0.26338312247158 0.649946720304317 1.06189137636783 0.357142857142857 12.3 12 3 hydroencephaly 0.00791577924636617 0.0781369082354597 1.06004460875676 0.356521739130435 12.3 12 3 abnormal retinal pigmentation 0.0192305977096014 0.146287803677779 1.05945024676699 0.35632183908046 12.3 12 3 decreased litter size 6.23658618751992e-05 0.00164164107316993 1.0581124034982 0.355871886120996 12.3 12 3 abnormal rib morphology 0.00460121892116721 0.0510961252964439 1.05717185913953 0.355555555555556 12.3 12 3 irregular heartbeat 0.0790876603600246 0.373005970088481 1.05717185913953 0.355555555555556 12.3 12 3 decreased osteoclast cell number 0.0790876603600246 0.373005970088481 1.05717185913953 0.355555555555556 12.3 12 3 cardiomyopathy 0.0790876603600246 0.373005970088481 1.05717185913953 0.355555555555556 12.3 12 3 abnormal bone mineralization 0.00709899030704694 0.0720764832195072 1.05662579929494 0.355371900826446 12.3 12 3 preaxial polydactyly 0.13312627829607 0.533255422321215 1.05504046426224 0.354838709677419 12.3 12 3 abnormal intestinal epithelium morphology 0.0741498194195078 0.358498883976726 1.05304228156477 0.354166666666667 12.3 12 3 abnormal kidney physiology 0.0741498194195078 0.358498883976726 1.05304228156477 0.354166666666667 12.3 12 3 abnormal motor coordination/ balance 0.015335792567638 0.125672379782582 1.05116520084897 0.353535353535354 12.3 12 3 enlarged heart 0.000345364781810932 0.00680108083261852 1.05090629316403 0.353448275862069 12.3 12 3 female infertility 0.000135645161680931 0.00309557192368181 1.05071357240607 0.353383458646617 12.3 12 3 abnormal cardiovascular system physiology 0.00570636173549348 0.0604024460299576 1.05071357240607 0.353383458646617 12.3 12 3 abnormal lung morphology 0.00881690970407101 0.0856721206596744 1.04939853664586 0.352941176470588 12.3 12 3 abnormal dendritic spine morphology 0.0695456483949786 0.345299002759499 1.04939853664586 0.352941176470588 12.3 12 3 thin skin 0.123945066035204 0.500915275000115 1.04939853664586 0.352941176470588 12.3 12 3 decreased osteoblast cell number 0.123945066035204 0.500915275000115 1.04939853664586 0.352941176470588 12.3 12 3 abnormal skin physiology 0.123945066035204 0.500915275000115 1.04939853664586 0.352941176470588 12.3 12 3 abnormal vagus nerve morphology 0.239818978189336 0.649946720304317 1.04939853664586 0.352941176470588 12.3 12 3 decreased vasoconstriction 0.239818978189336 0.649946720304317 1.04939853664586 0.352941176470588 12.3 12 3 absence seizures 0.239818978189336 0.649946720304317 1.04939853664586 0.352941176470588 12.3 12 3 abnormal duodenum morphology 0.239818978189336 0.649946720304317 1.04939853664586 0.352941176470588 12.3 12 3 abnormal melanosome morphology 0.239818978189336 0.649946720304317 1.04939853664586 0.352941176470588 12.3 12 3 increased hepatoma incidence 0.239818978189336 0.649946720304317 1.04939853664586 0.352941176470588 12.3 12 3 increased trabecular bone mass 0.239818978189336 0.649946720304317 1.04939853664586 0.352941176470588 12.3 12 3 abnormal ductus venosus valve morphology 0.239818978189336 0.649946720304317 1.04939853664586 0.352941176470588 12.3 12 3 decreased body fat mass 0.239818978189336 0.649946720304317 1.04939853664586 0.352941176470588 12.3 12 3 abnormal suckling behavior 0.0226960002551184 0.165642360949966 1.04741103941736 0.352272727272727 12.3 12 3 hyperglycemia 0.0226960002551184 0.165642360949966 1.04741103941736 0.352272727272727 12.3 12 3 short snout 0.0129422720075364 0.113558211157204 1.0461596522735 0.351851851851852 12.3 12 3 kidney cysts 0.0358841243095478 0.23614222015873 1.04467151621052 0.351351351351351 12.3 12 3 increased brown adipose tissue amount 0.115515001491357 0.4771905715158 1.04467151621052 0.351351351351351 12.3 12 3 increased white adipose tissue amount 0.115515001491357 0.4771905715158 1.04467151621052 0.351351351351351 12.3 12 3 abnormal hair follicle development 0.115515001491357 0.4771905715158 1.04467151621052 0.351351351351351 12.3 12 3 respiratory failure 0.00410941968119982 0.0481043833269861 1.04360715399329 0.350993377483444 12.3 12 3 neonatal lethality, incomplete penetrance 0.000250393561922676 0.00523406710321561 1.04065354884048 0.35 12.3 12 3 increased circulating insulin level 0.00348687718241712 0.0443662761701411 1.04065354884048 0.35 12.3 12 3 abnormal eating behavior 0.0574984636053758 0.316074074799581 1.04065354884048 0.35 12.3 12 3 impaired ovarian folliculogenesis 0.107757813589688 0.463750106062889 1.04065354884048 0.35 12.3 12 3 abnormal gait 7.57993705722262e-05 0.00192398912549401 1.03921020133862 0.349514563106796 12.3 12 3 cyanosis 0.00164597909929175 0.0238738950990568 1.0375563656594 0.348958333333333 12.3 12 3 abnormal left-right axis patterning 0.100605877403016 0.451727653501808 1.03719622808021 0.348837209302326 12.3 12 3 decreased oxygen consumption 0.100605877403016 0.451727653501808 1.03719622808021 0.348837209302326 12.3 12 3 abnormal vertebrae morphology 0.0151463466034296 0.124963639058146 1.03656185729851 0.348623853211009 12.3 12 3 abnormal blood vessel physiology 0.201644962611301 0.649946720304317 1.03418986220172 0.347826086956522 12.3 12 3 abnormal postnatal growth 0.201644962611301 0.649946720304317 1.03418986220172 0.347826086956522 12.3 12 3 abnormal sacral vertebrae morphology 0.201644962611301 0.649946720304317 1.03418986220172 0.347826086956522 12.3 12 3 dilated heart 0.201644962611301 0.649946720304317 1.03418986220172 0.347826086956522 12.3 12 3 abnormal palatal shelf fusion at midline 0.201644962611301 0.649946720304317 1.03418986220172 0.347826086956522 12.3 12 3 hyperactivity 2.16313735306367e-05 0.000640571924493556 1.03384141548265 0.347708894878706 12.3 12 3 increased circulating glucose level 0.00696269522396109 0.0709823949573902 1.0332730272175 0.347517730496454 12.3 12 3 organ of Corti degeneration 0.0878900595323526 0.400781893834513 1.03155162275733 0.346938775510204 12.3 12 3 abnormal hair growth 0.0822296346532538 0.378393941943126 1.02921779555652 0.346153846153846 12.3 12 3 abnormal stomach morphology 0.185831007791989 0.631064343866995 1.02921779555652 0.346153846153846 12.3 12 3 infertility 0.0187061277238196 0.14273464022393 1.02814903356736 0.345794392523364 12.3 12 3 decreased circulating calcium level 0.076979240154793 0.370047994891224 1.02713856768671 0.345454545454545 12.3 12 3 abnormal enzyme/coenzyme level 0.0721034516405755 0.34962443656127 1.02527443235515 0.344827586206897 12.3 12 3 abnormal outer ear morphology 0.171687138555591 0.589204555901094 1.02527443235515 0.344827586206897 12.3 12 3 decreased bone strength 0.171687138555591 0.589204555901094 1.02527443235515 0.344827586206897 12.3 12 3 decreased insulin secretion 0.0310764018507443 0.209776254012826 1.02413523854142 0.344444444444444 12.3 12 3 abnormal maternal nurturing 0.0675706853360675 0.33582833121572 1.02359365459719 0.344262295081967 12.3 12 3 impaired coordination 7.48560077762539e-05 0.00190978789070186 1.02260753354267 0.34393063583815 12.3 12 3 abnormal tooth morphology 0.0633526700725724 0.317401343012133 1.02207044975404 0.34375 12.3 12 3 decreased eosinophil cell number 0.0633526700725724 0.317401343012133 1.02207044975404 0.34375 12.3 12 3 increased circulating follicle stimulating hormone level 0.158951610793857 0.575953578805126 1.02207044975404 0.34375 12.3 12 3 abnormal lumbar vertebrae morphology 0.158951610793857 0.575953578805126 1.02207044975404 0.34375 12.3 12 3 abnormal spongiotrophoblast layer morphology 0.158951610793857 0.575953578805126 1.02207044975404 0.34375 12.3 12 3 rib fusion 0.0594240082361359 0.317401343012133 1.02068365131475 0.343283582089552 12.3 12 3 maternal effect 0.0594240082361359 0.317401343012133 1.02068365131475 0.343283582089552 12.3 12 3 abnormal kidney morphology 0.0043433623420991 0.0492384473337963 1.01941572131312 0.342857142857143 12.3 12 3 abnormal dermal layer morphology 0.147421994630477 0.574253747042547 1.01941572131312 0.342857142857143 12.3 12 3 ovary cysts 0.147421994630477 0.574253747042547 1.01941572131312 0.342857142857143 12.3 12 3 decreased glycogen level 0.147421994630477 0.574253747042547 1.01941572131312 0.342857142857143 12.3 12 3 increased sensitivity to induced morbidity/mortality 0.00367111729813193 0.0448006484451823 1.01803064560482 0.342391304347826 12.3 12 3 abnormal frontal bone morphology 0.136937626468432 0.546368229256635 1.01718016052077 0.342105263157895 12.3 12 3 hyporesponsive to tactile stimuli 0.136937626468432 0.546368229256635 1.01718016052077 0.342105263157895 12.3 12 3 decreased startle reflex 0.0181861509185934 0.139194001261542 1.01651140301878 0.341880341880342 12.3 12 3 abnormal astrocyte morphology 0.11860655871297 0.481687860895533 1.01362358653293 0.340909090909091 12.3 12 3 cochlear hair cell degeneration 0.11860655871297 0.481687860895533 1.01362358653293 0.340909090909091 12.3 12 3 limb grasping 0.00446513354931479 0.0497876805353873 1.01288100515086 0.340659340659341 12.3 12 3 abnormal myocardial fiber morphology 0.0319258888036975 0.215218559347419 1.01153364099369 0.34020618556701 12.3 12 3 hypoactivity 7.92073060985881e-05 0.0019801826524647 1.00950097954969 0.339522546419098 12.3 12 3 abnormal thoracic vertebrae morphology 0.0841937533203433 0.384985223133004 1.00789689960337 0.338983050847458 12.3 12 3 cataract 0.0197665836213627 0.150135501551572 1.00748041328122 0.338842975206612 12.3 12 3 abnormal skeletal muscle fiber morphology 0.0647775020151705 0.323887510075853 1.0050577534073 0.338028169014085 12.3 12 3 decreased liver weight 0.0647775020151705 0.323887510075853 1.0050577534073 0.338028169014085 12.3 12 3 obese 0.0569861217246589 0.313960083698979 1.00397002856595 0.337662337662338 12.3 12 3 abnormal lipid level 0.0502126725763954 0.291078233348796 1.00303956514745 0.337349397590361 12.3 12 3 decreased birth weight 0.0391446891429206 0.246824877675576 1.00153123497429 0.336842105263158 12.3 12 3 polydactyly 0.0368093826300725 0.241911068143475 1.00121186914682 0.336734693877551 12.3 12 3 abnormal pulmonary alveolus morphology 0.0346225245599965 0.231514865169332 1.00091147554671 0.336633663366337 12.3 12 3 decreased cardiac muscle contractility 0.0325737299369487 0.218992305995027 1.00062841234661 0.336538461538462 12.3 12 3 cleft palate 0.0189907413917663 0.144684438627928 0.998664256248223 0.33587786259542 12.3 12 3 abnormal cranium morphology 0.0179015109428034 0.138077545644103 0.998494876286173 0.335820895522388 12.3 12 3 neonatal lethality, complete penetrance 5.23102804625421e-05 0.00141436763750623 0.991098617943312 0.333333333333333 12.3 12 3 decreased inflammatory response 0.0577803667247601 0.316074074799581 0.991098617943312 0.333333333333333 12.3 12 3 abnormal neuromuscular synapse morphology 0.0747592953608611 0.360744417478452 0.991098617943312 0.333333333333333 12.3 12 3 increased susceptibility to bacterial infection induced morbidity/mortality 0.0747592953608611 0.360744417478452 0.991098617943312 0.333333333333333 12.3 12 3 abnormal optic nerve morphology 0.148859649025725 0.574253747042547 0.991098617943312 0.333333333333333 12.3 12 3 abnormal muscle morphology 0.148859649025725 0.574253747042547 0.991098617943312 0.333333333333333 12.3 12 3 abnormal scapula morphology 0.262295206363441 0.649946720304317 0.991098617943312 0.333333333333333 12.3 12 3 abnormal associative learning 0.262295206363441 0.649946720304317 0.991098617943312 0.333333333333333 12.3 12 3 decreased cochlear outer hair cell number 0.262295206363441 0.649946720304317 0.991098617943312 0.333333333333333 12.3 12 3 increased keratinocyte proliferation 0.262295206363441 0.649946720304317 0.991098617943312 0.333333333333333 12.3 12 3 increased bone ossification 0.262295206363441 0.649946720304317 0.991098617943312 0.333333333333333 12.3 12 3 lowered ear position 0.288320810480316 0.700046867808479 0.991098617943312 0.333333333333333 12.3 12 3 right pulmonary isomerism 0.288320810480316 0.700046867808479 0.991098617943312 0.333333333333333 12.3 12 3 blepharoptosis 0.288320810480316 0.700046867808479 0.991098617943312 0.333333333333333 12.3 12 3 abnormal thyroid cartilage morphology 0.288320810480316 0.700046867808479 0.991098617943312 0.333333333333333 12.3 12 3 abnormal metacarpal bone morphology 0.288320810480316 0.700046867808479 0.991098617943312 0.333333333333333 12.3 12 3 absent allantois 0.288320810480316 0.700046867808479 0.991098617943312 0.333333333333333 12.3 12 3 increased circulating glycerol level 0.288320810480316 0.700046867808479 0.991098617943312 0.333333333333333 12.3 12 3 long tibia 0.288320810480316 0.700046867808479 0.991098617943312 0.333333333333333 12.3 12 3 abnormal eye anterior chamber morphology 0.288320810480316 0.700046867808479 0.991098617943312 0.333333333333333 12.3 12 3 kinked tail 0.0397089370445752 0.247249013512843 0.991098617943312 0.333333333333333 12.3 12 3 abnormal long bone epiphyseal plate morphology 0.0975413981778272 0.440352500848176 0.991098617943312 0.333333333333333 12.3 12 3 abnormal cued conditioning behavior 0.119967508097661 0.486024717252332 0.991098617943312 0.333333333333333 12.3 12 3 abnormal response to novel object 0.119967508097661 0.486024717252332 0.991098617943312 0.333333333333333 12.3 12 3 abnormal thrombosis 0.119967508097661 0.486024717252332 0.991098617943312 0.333333333333333 12.3 12 3 curly tail 0.128768966810112 0.517050532591045 0.991098617943312 0.333333333333333 12.3 12 3 small lens 0.160370686295337 0.578660850335057 0.991098617943312 0.333333333333333 12.3 12 3 abnormal tooth development 0.187064850016044 0.633956150429031 0.991098617943312 0.333333333333333 12.3 12 3 cardiovascular system phenotype 0.187064850016044 0.633956150429031 0.991098617943312 0.333333333333333 12.3 12 3 decreased sensitivity to xenobiotic induced morbidity/mortality 0.187064850016044 0.633956150429031 0.991098617943312 0.333333333333333 12.3 12 3 abnormal hair cycle 0.20265533582685 0.649946720304317 0.991098617943312 0.333333333333333 12.3 12 3 blindness 0.239812027789042 0.649946720304317 0.991098617943312 0.333333333333333 12.3 12 3 disorganized myocardium 0.20265533582685 0.649946720304317 0.991098617943312 0.333333333333333 12.3 12 3 abnormal prostate gland morphology 0.319052642757019 0.754567240900535 0.991098617943312 0.333333333333333 12.3 12 3 audiogenic seizures 0.319052642757019 0.754567240900535 0.991098617943312 0.333333333333333 12.3 12 3 abnormal seizure response to electrical stimulation 0.319052642757019 0.754567240900535 0.991098617943312 0.333333333333333 12.3 12 3 abnormal apical ectodermal ridge morphology 0.319052642757019 0.754567240900535 0.991098617943312 0.333333333333333 12.3 12 3 abnormal respiratory system morphology 0.319052642757019 0.754567240900535 0.991098617943312 0.333333333333333 12.3 12 3 dilated ureter 0.319052642757019 0.754567240900535 0.991098617943312 0.333333333333333 12.3 12 3 abnormal glial cell morphology 0.319052642757019 0.754567240900535 0.991098617943312 0.333333333333333 12.3 12 3 abnormal energy homeostasis 0.319052642757019 0.754567240900535 0.991098617943312 0.333333333333333 12.3 12 3 liver vascular congestion 0.319052642757019 0.754567240900535 0.991098617943312 0.333333333333333 12.3 12 3 bicuspid aortic valve 0.319052642757019 0.754567240900535 0.991098617943312 0.333333333333333 12.3 12 3 decreased brown adipose tissue mass 0.319052642757019 0.754567240900535 0.991098617943312 0.333333333333333 12.3 12 3 increased circulating corticosterone level 0.138366007889443 0.550256506195029 0.991098617943312 0.333333333333333 12.3 12 3 small placenta 0.138366007889443 0.550256506195029 0.991098617943312 0.333333333333333 12.3 12 3 abnormal metabolism 0.138366007889443 0.550256506195029 0.991098617943312 0.333333333333333 12.3 12 3 abnormal trigeminal nerve morphology 0.220108902289668 0.649946720304317 0.991098617943312 0.333333333333333 12.3 12 3 wrinkled skin 0.220108902289668 0.649946720304317 0.991098617943312 0.333333333333333 12.3 12 3 improved glucose tolerance 0.00727050095962603 0.0736674995399989 0.986041992341561 0.331632653061224 12.3 12 3 increased body weight 0.00493249446331335 0.0536961924616716 0.982249523140247 0.330357142857143 12.3 12 3 small ovary 0.0582280336191228 0.316074074799581 0.98020742433954 0.32967032967033 12.3 12 3 small kidney 0.0620404391211882 0.317401343012133 0.979836133648502 0.329545454545455 12.3 12 3 postnatal lethality, complete penetrance 0.000372657993021544 0.00724208404407102 0.978260552944046 0.329015544041451 12.3 12 3 abnormal trabecular bone morphology 0.0378988084968518 0.24292221488695 0.974441498314013 0.327731092436975 12.3 12 3 abnormal long bone hypertrophic chondrocyte zone 0.148589043065995 0.574253747042547 0.970872115536306 0.326530612244898 12.3 12 3 increased startle reflex 0.070611647033819 0.348255364423525 0.968826738888406 0.325842696629214 12.3 12 3 abnormal posture 0.0856941699108234 0.391127059914079 0.966321152494729 0.325 12.3 12 3 decreased circulating chloride level 0.200660262176102 0.649946720304317 0.964312168809709 0.324324324324324 12.3 12 3 increased circulating free fatty acid level 0.104462017591408 0.453872151237091 0.963180347015332 0.323943661971831 12.3 12 3 abnormal retina morphology 0.0111232027429032 0.101724142731514 0.962781514573503 0.323809523809524 12.3 12 3 abnormal oocyte morphology 0.217252572789488 0.649946720304317 0.961948658592038 0.323529411764706 12.3 12 3 abnormal cranial ganglia morphology 0.235764410841508 0.649946720304317 0.959127694783851 0.32258064516129 12.3 12 3 abnormal postnatal growth/weight/body size 0.235764410841508 0.649946720304317 0.959127694783851 0.32258064516129 12.3 12 3 abnormal nose morphology 0.235764410841508 0.649946720304317 0.959127694783851 0.32258064516129 12.3 12 3 decreased neuronal precursor cell number 0.235764410841508 0.649946720304317 0.959127694783851 0.32258064516129 12.3 12 3 abnormal podocyte morphology 0.235764410841508 0.649946720304317 0.959127694783851 0.32258064516129 12.3 12 3 abnormal colon morphology 0.137253736076382 0.547145302067307 0.9575020546232 0.322033898305085 12.3 12 3 abnormal seminal vesicle morphology 0.147243590635349 0.574253747042547 0.955702238731051 0.321428571428571 12.3 12 3 myoclonus 0.256563244539582 0.649946720304317 0.955702238731051 0.321428571428571 12.3 12 3 shortened head 0.256563244539582 0.649946720304317 0.955702238731051 0.321428571428571 12.3 12 3 abnormal ovulation 0.256563244539582 0.649946720304317 0.955702238731051 0.321428571428571 12.3 12 3 abnormal respiration 0.256563244539582 0.649946720304317 0.955702238731051 0.321428571428571 12.3 12 3 enhanced coordination 0.256563244539582 0.649946720304317 0.955702238731051 0.321428571428571 12.3 12 3 increased triglyceride level 0.256563244539582 0.649946720304317 0.955702238731051 0.321428571428571 12.3 12 3 prolonged QRS complex duration 0.256563244539582 0.649946720304317 0.955702238731051 0.321428571428571 12.3 12 3 abnormal skeleton development 0.0970918186823869 0.438720979059832 0.95439126172319 0.320987654320988 12.3 12 3 increased total body fat amount 0.0426160802651454 0.258554877218413 0.95411732622901 0.32089552238806 12.3 12 3 abnormal heart ventricle morphology 0.103675059170449 0.453872151237091 0.952979440330108 0.320512820512821 12.3 12 3 abnormal lens morphology 0.0480744686102672 0.288504802576694 0.952383828179902 0.3203125 12.3 12 3 increased body length 0.169967312024063 0.589204555901094 0.95145467322558 0.32 12.3 12 3 mandible hypoplasia 0.280136793788388 0.684182891063934 0.95145467322558 0.32 12.3 12 3 abnormal keratinocyte physiology 0.280136793788388 0.684182891063934 0.95145467322558 0.32 12.3 12 3 abnormal cochlear outer hair cell morphology 0.280136793788388 0.684182891063934 0.95145467322558 0.32 12.3 12 3 pulmonary hypoplasia 0.182928842555794 0.621633191062211 0.948924208669129 0.319148936170213 12.3 12 3 abnormal locomotor activation 0.0901428938445353 0.409553330480879 0.947533843528222 0.318681318681319 12.3 12 3 abnormal basisphenoid bone morphology 0.307154927931895 0.733251327476574 0.946048680764071 0.318181818181818 12.3 12 3 increased body size 0.307154927931895 0.733251327476574 0.946048680764071 0.318181818181818 12.3 12 3 increased coping response 0.307154927931895 0.733251327476574 0.946048680764071 0.318181818181818 12.3 12 3 abnormal retinal layer morphology 0.307154927931895 0.733251327476574 0.946048680764071 0.318181818181818 12.3 12 3 abnormal limb posture 0.307154927931895 0.733251327476574 0.946048680764071 0.318181818181818 12.3 12 3 abnormal basement membrane morphology 0.307154927931895 0.733251327476574 0.946048680764071 0.318181818181818 12.3 12 3 abnormal blood-brain barrier function 0.307154927931895 0.733251327476574 0.946048680764071 0.318181818181818 12.3 12 3 abnormal cholesterol homeostasis 0.212786698492807 0.649946720304317 0.942752343897297 0.317073170731707 12.3 12 3 cardiac hypertrophy 0.0890805112745747 0.405096474946078 0.940532361925796 0.316326530612245 12.3 12 3 abnormal axial skeleton morphology 0.12482855700816 0.503667535373558 0.938935532788401 0.315789473684211 12.3 12 3 abnormal reproductive system physiology 0.230070709425797 0.649946720304317 0.938935532788401 0.315789473684211 12.3 12 3 decreased total retina thickness 0.230070709425797 0.649946720304317 0.938935532788401 0.315789473684211 12.3 12 3 enlarged adrenal glands 0.338578171024454 0.778745446531049 0.938935532788401 0.315789473684211 12.3 12 3 flaky skin 0.338578171024454 0.778745446531049 0.938935532788401 0.315789473684211 12.3 12 3 thin dermal layer 0.338578171024454 0.778745446531049 0.938935532788401 0.315789473684211 12.3 12 3 unresponsive to tactile stimuli 0.338578171024454 0.778745446531049 0.938935532788401 0.315789473684211 12.3 12 3 delayed sexual maturation 0.338578171024454 0.778745446531049 0.938935532788401 0.315789473684211 12.3 12 3 abnormal neural crest cell migration 0.338578171024454 0.778745446531049 0.938935532788401 0.315789473684211 12.3 12 3 abnormal metatarsal bone morphology 0.338578171024454 0.778745446531049 0.938935532788401 0.315789473684211 12.3 12 3 abnormal response to novelty 0.338578171024454 0.778745446531049 0.938935532788401 0.315789473684211 12.3 12 3 increased left ventricle weight 0.338578171024454 0.778745446531049 0.938935532788401 0.315789473684211 12.3 12 3 abnormal cochlear inner hair cell morphology 0.338578171024454 0.778745446531049 0.938935532788401 0.315789473684211 12.3 12 3 decreased eye pigmentation 0.338578171024454 0.778745446531049 0.938935532788401 0.315789473684211 12.3 12 3 eyelids fail to open 0.338578171024454 0.778745446531049 0.938935532788401 0.315789473684211 12.3 12 3 abnormal chondrocyte morphology 0.179357272415171 0.610159649082404 0.936037583613128 0.314814814814815 12.3 12 3 diluted coat color 0.179357272415171 0.610159649082404 0.936037583613128 0.314814814814815 12.3 12 3 polyphagia 0.179357272415171 0.610159649082404 0.936037583613128 0.314814814814815 12.3 12 3 decreased bone volume 0.249258254445701 0.649946720304317 0.934464411203694 0.314285714285714 12.3 12 3 abnormal cervical vertebrae morphology 0.192824365247561 0.649295386447709 0.932798699240764 0.313725490196078 12.3 12 3 abnormal gluconeogenesis 0.192824365247561 0.649295386447709 0.932798699240764 0.313725490196078 12.3 12 3 decreased compact bone thickness 0.152737529886838 0.574253747042547 0.931928551200428 0.313432835820896 12.3 12 3 abnormal spatial learning 0.0455807490599205 0.274570657666337 0.930295021750471 0.312883435582822 12.3 12 3 oligodactyly 0.207546967894742 0.649946720304317 0.929154954321855 0.3125 12.3 12 3 abnormal social investigation 0.13100628373965 0.525186351011088 0.929154954321855 0.3125 12.3 12 3 abnormal retinal pigment epithelium morphology 0.13100628373965 0.525186351011088 0.929154954321855 0.3125 12.3 12 3 abnormal vertebral body morphology 0.270679319954076 0.663037723668896 0.929154954321855 0.3125 12.3 12 3 kidney cortex cysts 0.270679319954076 0.663037723668896 0.929154954321855 0.3125 12.3 12 3 polydipsia 0.270679319954076 0.663037723668896 0.929154954321855 0.3125 12.3 12 3 pancreatic islet hyperplasia 0.270679319954076 0.663037723668896 0.929154954321855 0.3125 12.3 12 3 absent mandible 0.375862570401462 0.818344108423315 0.929154954321855 0.3125 12.3 12 3 delayed hair appearance 0.375862570401462 0.818344108423315 0.929154954321855 0.3125 12.3 12 3 disorganized retinal layers 0.375862570401462 0.818344108423315 0.929154954321855 0.3125 12.3 12 3 reduced male mating frequency 0.375862570401462 0.818344108423315 0.929154954321855 0.3125 12.3 12 3 intraventricular hemorrhage 0.375862570401462 0.818344108423315 0.929154954321855 0.3125 12.3 12 3 abnormal meiosis 0.375862570401462 0.818344108423315 0.929154954321855 0.3125 12.3 12 3 abnormal epicardium morphology 0.375862570401462 0.818344108423315 0.929154954321855 0.3125 12.3 12 3 abnormal epididymis epithelium morphology 0.375862570401462 0.818344108423315 0.929154954321855 0.3125 12.3 12 3 decreased circulating triiodothyronine level 0.375862570401462 0.818344108423315 0.929154954321855 0.3125 12.3 12 3 dilated respiratory conducting tubes 0.375862570401462 0.818344108423315 0.929154954321855 0.3125 12.3 12 3 decreased adipocyte glucose uptake 0.375862570401462 0.818344108423315 0.929154954321855 0.3125 12.3 12 3 abnormal ovarian follicle morphology 0.223688386824592 0.649946720304317 0.925025376747091 0.311111111111111 12.3 12 3 abnormal intestine morphology 0.149529055045005 0.574253747042547 0.924132495109305 0.310810810810811 12.3 12 3 cochlear ganglion degeneration 0.188085891992185 0.636549192286478 0.922746989119635 0.310344827586207 12.3 12 3 glomerulosclerosis 0.188085891992185 0.636549192286478 0.922746989119635 0.310344827586207 12.3 12 3 abnormal microglial cell morphology 0.294757492232378 0.708414745824193 0.922746989119635 0.310344827586207 12.3 12 3 absent long term depression 0.294757492232378 0.708414745824193 0.922746989119635 0.310344827586207 12.3 12 3 increased food intake 0.13694898128302 0.546368229256635 0.92030585951879 0.30952380952381 12.3 12 3 abnormal cartilage morphology 0.241443651702189 0.649946720304317 0.92030585951879 0.30952380952381 12.3 12 3 abnormal pancreas morphology 0.241443651702189 0.649946720304317 0.92030585951879 0.30952380952381 12.3 12 3 increased anxiety-related response 0.0727299451399987 0.352318867645076 0.91979655909847 0.309352517985612 12.3 12 3 increased circulating calcium level 0.201951280848323 0.649946720304317 0.919018718456526 0.309090909090909 12.3 12 3 abnormal contextual conditioning behavior 0.201951280848323 0.649946720304317 0.919018718456526 0.309090909090909 12.3 12 3 decreased susceptibility to injury 0.171063814312104 0.589204555901094 0.918223719565127 0.308823529411765 12.3 12 3 abnormal female meiosis 0.217058602094438 0.649946720304317 0.914860262716904 0.307692307692308 12.3 12 3 abnormal xiphoid process morphology 0.322050476453455 0.754567240900535 0.914860262716904 0.307692307692308 12.3 12 3 abnormal heart looping 0.261048497483779 0.649946720304317 0.914860262716904 0.307692307692308 12.3 12 3 abnormal blood homeostasis 0.106204339209363 0.457460248975396 0.912853990210946 0.307017543859649 12.3 12 3 respiratory distress 0.0599851115330649 0.317401343012133 0.910894105508593 0.30635838150289 12.3 12 3 absent kidney 0.233557817083894 0.649946720304317 0.910192608315287 0.306122448979592 12.3 12 3 cardiac fibrosis 0.152113781049485 0.574253747042547 0.909478731759745 0.305882352941176 12.3 12 3 heart right ventricle hypertrophy 0.282791829866365 0.689651643914296 0.908507066448036 0.305555555555556 12.3 12 3 abnormal uterus morphology 0.282791829866365 0.689651643914296 0.908507066448036 0.305555555555556 12.3 12 3 abnormal epidermis stratum granulosum morphology 0.282791829866365 0.689651643914296 0.908507066448036 0.305555555555556 12.3 12 3 alopecia 0.139147737967952 0.552923319800767 0.907637681695454 0.305263157894737 12.3 12 3 abnormal response/metabolism to endogenous compounds 0.162249916833331 0.582390574491936 0.906492638362786 0.304878048780488 12.3 12 3 abnormal epidermal layer morphology 0.190494848835479 0.6438260006498 0.904916129426503 0.304347826086957 12.3 12 3 abnormal coat appearance 0.190494848835479 0.6438260006498 0.904916129426503 0.304347826086957 12.3 12 3 abnormal forelimb morphology 0.251625018708104 0.649946720304317 0.904916129426503 0.304347826086957 12.3 12 3 abnormal sleep pattern 0.251625018708104 0.649946720304317 0.904916129426503 0.304347826086957 12.3 12 3 abnormal pulmonary artery morphology 0.353315537759655 0.807416077333158 0.904916129426503 0.304347826086957 12.3 12 3 abnormal cochlear ganglion morphology 0.353315537759655 0.807416077333158 0.904916129426503 0.304347826086957 12.3 12 3 abnormal Wolffian duct morphology 0.353315537759655 0.807416077333158 0.904916129426503 0.304347826086957 12.3 12 3 abnormal lens development 0.353315537759655 0.807416077333158 0.904916129426503 0.304347826086957 12.3 12 3 abnormal chondrocyte physiology 0.353315537759655 0.807416077333158 0.904916129426503 0.304347826086957 12.3 12 3 reduced long term potentiation 0.1243656920836 0.502207238730447 0.902607669912659 0.303571428571429 12.3 12 3 enhanced long term potentiation 0.22579822273603 0.649946720304317 0.902607669912659 0.303571428571429 12.3 12 3 abnormal motor capabilities/coordination/movement 0.105060082040396 0.453872151237091 0.900998743584829 0.303030303030303 12.3 12 3 abnormal aorta morphology 0.307033437318438 0.733251327476574 0.900998743584829 0.303030303030303 12.3 12 3 abnormal epidermis stratum basale morphology 0.307033437318438 0.733251327476574 0.900998743584829 0.303030303030303 12.3 12 3 abnormal skeleton physiology 0.307033437318438 0.733251327476574 0.900998743584829 0.303030303030303 12.3 12 3 abnormal male reproductive system morphology 0.271468919028274 0.664317694129692 0.898903397669516 0.302325581395349 12.3 12 3 delayed endochondral bone ossification 0.271468919028274 0.664317694129692 0.898903397669516 0.302325581395349 12.3 12 3 abnormal urine homeostasis 0.153482035215226 0.574253747042547 0.898183122511127 0.302083333333333 12.3 12 3 increased circulating cholesterol level 0.0784461766196875 0.373005970088481 0.895367501437424 0.301136363636364 12.3 12 3 abnormal incisor morphology 0.233864776947834 0.649946720304317 0.891988756148981 0.3 12.3 12 3 abnormal action potential 0.210973363232096 0.649946720304317 0.891988756148981 0.3 12.3 12 3 decreased oocyte number 0.260810890680965 0.649946720304317 0.891988756148981 0.3 12.3 12 3 delayed eyelid opening 0.334229844977605 0.773392315703993 0.891988756148981 0.3 12.3 12 3 abnormal lactation 0.334229844977605 0.773392315703993 0.891988756148981 0.3 12.3 12 3 emphysema 0.334229844977605 0.773392315703993 0.891988756148981 0.3 12.3 12 3 abnormal pericardium morphology 0.38962083260543 0.84313338069248 0.891988756148981 0.3 12.3 12 3 abnormal hearing physiology 0.38962083260543 0.84313338069248 0.891988756148981 0.3 12.3 12 3 abnormal trachea morphology 0.38962083260543 0.84313338069248 0.891988756148981 0.3 12.3 12 3 abnormal hyoid bone morphology 0.38962083260543 0.84313338069248 0.891988756148981 0.3 12.3 12 3 abnormal optic stalk morphology 0.38962083260543 0.84313338069248 0.891988756148981 0.3 12.3 12 3 abnormal postnatal subventricular zone morphology 0.38962083260543 0.84313338069248 0.891988756148981 0.3 12.3 12 3 kidney atrophy 0.38962083260543 0.84313338069248 0.891988756148981 0.3 12.3 12 3 abnormal neuron proliferation 0.38962083260543 0.84313338069248 0.891988756148981 0.3 12.3 12 3 nuclear cataracts 0.38962083260543 0.84313338069248 0.891988756148981 0.3 12.3 12 3 cleft secondary palate 0.179334887557572 0.610159649082404 0.885662594757854 0.297872340425532 12.3 12 3 hydronephrosis 0.197230529984675 0.649946720304317 0.884909480306529 0.297619047619048 12.3 12 3 decreased exploration in new environment 0.197230529984675 0.649946720304317 0.884909480306529 0.297619047619048 12.3 12 3 increased circulating triglyceride level 0.125582262110435 0.504662159934905 0.88173601182543 0.296551724137931 12.3 12 3 abnormal long bone epiphyseal plate proliferative zone 0.269155332216962 0.660605711780653 0.880976549282944 0.296296296296296 12.3 12 3 rectal prolapse 0.364973244522417 0.812149364160577 0.880976549282944 0.296296296296296 12.3 12 3 thin epidermis 0.364973244522417 0.812149364160577 0.880976549282944 0.296296296296296 12.3 12 3 abnormal palate morphology 0.364973244522417 0.812149364160577 0.880976549282944 0.296296296296296 12.3 12 3 decreased bone ossification 0.364973244522417 0.812149364160577 0.880976549282944 0.296296296296296 12.3 12 3 atelectasis 0.232430495830132 0.649946720304317 0.87942553423139 0.295774647887324 12.3 12 3 abnormal skeleton morphology 0.163077804673559 0.584940215033133 0.87906138287146 0.295652173913043 12.3 12 3 abnormal gametogenesis 0.302637581612755 0.725950804495399 0.878473774995209 0.295454545454545 12.3 12 3 abnormal amino acid level 0.302637581612755 0.725950804495399 0.878473774995209 0.295454545454545 12.3 12 3 absent gastric milk in neonates 0.224007259992027 0.649946720304317 0.876741085103699 0.294871794871795 12.3 12 3 short maxilla 0.344442130872166 0.790041309861239 0.874498780538217 0.294117647058824 12.3 12 3 lung hemorrhage 0.344442130872166 0.790041309861239 0.874498780538217 0.294117647058824 12.3 12 3 overexpanded pulmonary alveoli 0.344442130872166 0.790041309861239 0.874498780538217 0.294117647058824 12.3 12 3 increased susceptibility to weight gain 0.344442130872166 0.790041309861239 0.874498780538217 0.294117647058824 12.3 12 3 distended urinary bladder 0.432547400489847 0.843951343255129 0.874498780538217 0.294117647058824 12.3 12 3 increased incidence of corneal inflammation 0.432547400489847 0.843951343255129 0.874498780538217 0.294117647058824 12.3 12 3 abnormal cranial suture morphology 0.432547400489847 0.843951343255129 0.874498780538217 0.294117647058824 12.3 12 3 abnormal glutamate-mediated receptor currents 0.432547400489847 0.843951343255129 0.874498780538217 0.294117647058824 12.3 12 3 abnormal involuntary movement 0.432547400489847 0.843951343255129 0.874498780538217 0.294117647058824 12.3 12 3 abnormal testis development 0.432547400489847 0.843951343255129 0.874498780538217 0.294117647058824 12.3 12 3 coloboma 0.432547400489847 0.843951343255129 0.874498780538217 0.294117647058824 12.3 12 3 increased circulating magnesium level 0.432547400489847 0.843951343255129 0.874498780538217 0.294117647058824 12.3 12 3 abnormal survival 0.432547400489847 0.843951343255129 0.874498780538217 0.294117647058824 12.3 12 3 abnormal electroretinogram waveform feature 0.432547400489847 0.843951343255129 0.874498780538217 0.294117647058824 12.3 12 3 deafness 0.201263958498564 0.649946720304317 0.870965452132002 0.292929292929293 12.3 12 3 abnormal CNS synaptic transmission 0.201263958498564 0.649946720304317 0.870965452132002 0.292929292929293 12.3 12 3 abnormal cardiovascular system morphology 0.31091903818237 0.741525510526026 0.867211290700398 0.291666666666667 12.3 12 3 abnormal body weight 0.40005227715932 0.843951343255129 0.867211290700398 0.291666666666667 12.3 12 3 curly vibrissae 0.40005227715932 0.843951343255129 0.867211290700398 0.291666666666667 12.3 12 3 abnormal nursing 0.40005227715932 0.843951343255129 0.867211290700398 0.291666666666667 12.3 12 3 increased stereotypic behavior 0.40005227715932 0.843951343255129 0.867211290700398 0.291666666666667 12.3 12 3 abnormal vasodilation 0.40005227715932 0.843951343255129 0.867211290700398 0.291666666666667 12.3 12 3 abnormal cardiac muscle contractility 0.40005227715932 0.843951343255129 0.867211290700398 0.291666666666667 12.3 12 3 prolonged QT interval 0.40005227715932 0.843951343255129 0.867211290700398 0.291666666666667 12.3 12 3 abnormal joint morphology 0.296726225086147 0.712802013425196 0.864958793841436 0.290909090909091 12.3 12 3 absent mature ovarian follicles 0.374511158942372 0.818344108423315 0.863214925305466 0.290322580645161 12.3 12 3 abnormal retinal photoreceptor layer morphology 0.374511158942372 0.818344108423315 0.863214925305466 0.290322580645161 12.3 12 3 decreased heart rate 0.218690903849378 0.649946720304317 0.862255797610682 0.29 12.3 12 3 abnormal compact bone morphology 0.353175356562279 0.807416077333158 0.860690905056034 0.289473684210526 12.3 12 3 decreased body temperature 0.318360234280649 0.754567240900535 0.857681496297097 0.288461538461538 12.3 12 3 short limbs 0.255986509210184 0.649946720304317 0.854395360295959 0.28735632183908 12.3 12 3 increased circulating LDL cholesterol level 0.34186352662176 0.785575540389495 0.849513101094268 0.285714285714286 12.3 12 3 increased fluid intake 0.34186352662176 0.785575540389495 0.849513101094268 0.285714285714286 12.3 12 3 abnormal vibrissa morphology 0.360762923053633 0.812149364160577 0.849513101094268 0.285714285714286 12.3 12 3 abnormal artery morphology 0.382515681442752 0.832101230947832 0.849513101094268 0.285714285714286 12.3 12 3 abnormal anxiety-related response 0.440551083102225 0.843951343255129 0.849513101094268 0.285714285714286 12.3 12 3 abnormal erythrocyte physiology 0.440551083102225 0.843951343255129 0.849513101094268 0.285714285714286 12.3 12 3 abnormal embryonic/fetal subventricular zone morphology 0.440551083102225 0.843951343255129 0.849513101094268 0.285714285714286 12.3 12 3 decreased vocalization 0.440551083102225 0.843951343255129 0.849513101094268 0.285714285714286 12.3 12 3 abnormal hair follicle morphology 0.310000111132227 0.739688514572099 0.849513101094268 0.285714285714286 12.3 12 3 abnormal stria vascularis morphology 0.408337244515551 0.843951343255129 0.849513101094268 0.285714285714286 12.3 12 3 rib bifurcation 0.408337244515551 0.843951343255129 0.849513101094268 0.285714285714286 12.3 12 3 absent corpus callosum 0.408337244515551 0.843951343255129 0.849513101094268 0.285714285714286 12.3 12 3 increased bone resorption 0.408337244515551 0.843951343255129 0.849513101094268 0.285714285714286 12.3 12 3 increased liver weight 0.27702116524769 0.677571434172693 0.844686322110777 0.284090909090909 12.3 12 3 enlarged kidney 0.348285918990209 0.798121808832929 0.841498826555642 0.283018867924528 12.3 12 3 abnormal pancreatic islet morphology 0.348285918990209 0.798121808832929 0.841498826555642 0.283018867924528 12.3 12 3 delayed wound healing 0.367441411775309 0.812149364160577 0.840279263038895 0.282608695652174 12.3 12 3 abnormal lens fiber morphology 0.389368051200261 0.84313338069248 0.838621907490495 0.282051282051282 12.3 12 3 abnormal circulating hormone level 0.389368051200261 0.84313338069248 0.838621907490495 0.282051282051282 12.3 12 3 abnormal crypts of Lieberkuhn morphology 0.415141008981271 0.843951343255129 0.83623945888967 0.28125 12.3 12 3 decreased susceptibility to parasitic infection 0.415141008981271 0.843951343255129 0.83623945888967 0.28125 12.3 12 3 seizures 0.268243076634155 0.658691661527603 0.834609362478579 0.280701754385965 12.3 12 3 abnormal axon extension 0.373383996154291 0.817599199325528 0.832522839072382 0.28 12.3 12 3 abnormal systemic arterial blood pressure 0.420871008972131 0.843951343255129 0.82591551495276 0.277777777777778 12.3 12 3 impaired wound healing 0.420871008972131 0.843951343255129 0.82591551495276 0.277777777777778 12.3 12 3 abnormal limb bone morphology 0.420871008972131 0.843951343255129 0.82591551495276 0.277777777777778 12.3 12 3 head tilt 0.420871008972131 0.843951343255129 0.82591551495276 0.277777777777778 12.3 12 3 abnormal mitral valve morphology 0.488019165878129 0.892608584648415 0.82591551495276 0.277777777777778 12.3 12 3 abnormal stomach glandular epithelium morphology 0.488019165878129 0.892608584648415 0.82591551495276 0.277777777777778 12.3 12 3 delayed kidney development 0.488019165878129 0.892608584648415 0.82591551495276 0.277777777777778 12.3 12 3 abnormal radius morphology 0.488019165878129 0.892608584648415 0.82591551495276 0.277777777777778 12.3 12 3 abnormal phrenic nerve morphology 0.488019165878129 0.892608584648415 0.82591551495276 0.277777777777778 12.3 12 3 increased circulating renin level 0.488019165878129 0.892608584648415 0.82591551495276 0.277777777777778 12.3 12 3 abnormal pregnancy 0.488019165878129 0.892608584648415 0.82591551495276 0.277777777777778 12.3 12 3 abnormal sperm axoneme morphology 0.488019165878129 0.892608584648415 0.82591551495276 0.277777777777778 12.3 12 3 small thoracic cage 0.488019165878129 0.892608584648415 0.82591551495276 0.277777777777778 12.3 12 3 abnormal maxilla morphology 0.378720760056842 0.824206378513907 0.82591551495276 0.277777777777778 12.3 12 3 short tail 0.335442845632408 0.775838287782999 0.823925357085404 0.27710843373494 12.3 12 3 abnormal neuron differentiation 0.30246778672039 0.725950804495399 0.822965816685072 0.276785714285714 12.3 12 3 abnormal innervation 0.400580920301254 0.843951343255129 0.822400980846578 0.276595744680851 12.3 12 3 focal hair loss 0.451605721575807 0.863797948804168 0.82021954588412 0.275862068965517 12.3 12 3 decreased retinal photoreceptor cell number 0.451605721575807 0.863797948804168 0.82021954588412 0.275862068965517 12.3 12 3 stomach inflammation 0.451605721575807 0.863797948804168 0.82021954588412 0.275862068965517 12.3 12 3 increased retinal apoptosis 0.451605721575807 0.863797948804168 0.82021954588412 0.275862068965517 12.3 12 3 decreased circulating phosphate level 0.425792671670683 0.843951343255129 0.817656359803232 0.275 12.3 12 3 distended abdomen 0.405260628900194 0.843951343255129 0.816198861835669 0.274509803921569 12.3 12 3 short femur 0.363045163122006 0.812149364160577 0.810898869226346 0.272727272727273 12.3 12 3 abnormal circadian rhythm 0.430087379849395 0.843951343255129 0.810898869226346 0.272727272727273 12.3 12 3 belly spot 0.455681348354833 0.870255166243875 0.810898869226346 0.272727272727273 12.3 12 3 decreased systemic arterial blood pressure 0.455681348354833 0.870255166243875 0.810898869226346 0.272727272727273 12.3 12 3 dilated heart atrium 0.455681348354833 0.870255166243875 0.810898869226346 0.272727272727273 12.3 12 3 single kidney 0.455681348354833 0.870255166243875 0.810898869226346 0.272727272727273 12.3 12 3 testis hypoplasia 0.490574641291099 0.895965066234661 0.810898869226346 0.272727272727273 12.3 12 3 decreased airway responsiveness 0.490574641291099 0.895965066234661 0.810898869226346 0.272727272727273 12.3 12 3 abnormal cochlear sensory epithelium morphology 0.490574641291099 0.895965066234661 0.810898869226346 0.272727272727273 12.3 12 3 failure of palatal shelf elevation 0.490574641291099 0.895965066234661 0.810898869226346 0.272727272727273 12.3 12 3 circling 0.383657482422208 0.834220268815771 0.804538878095159 0.270588235294118 12.3 12 3 thick skin 0.492604455119695 0.898682495130357 0.800502729877291 0.269230769230769 12.3 12 3 no spontaneous movement 0.492604455119695 0.898682495130357 0.800502729877291 0.269230769230769 12.3 12 3 abnormal ocular fundus morphology 0.492604455119695 0.898682495130357 0.800502729877291 0.269230769230769 12.3 12 3 abnormal eye development 0.440336253833533 0.843951343255129 0.796418532275876 0.267857142857143 12.3 12 3 enhanced paired-pulse facilitation 0.494287858520608 0.901423055769804 0.79287889435465 0.266666666666667 12.3 12 3 decreased food intake 0.428195458404635 0.843951343255129 0.790369783929477 0.265822784810127 12.3 12 3 abnormal epidermis stratum corneum morphology 0.467113486201173 0.8735635783156 0.788833593873249 0.26530612244898 12.3 12 3 impaired synaptic plasticity 0.495727466648593 0.902724797429265 0.787048902484395 0.264705882352941 12.3 12 3 abnormal vision 0.495727466648593 0.902724797429265 0.787048902484395 0.264705882352941 12.3 12 3 increased width of hypertrophic chondrocyte zone 0.495727466648593 0.902724797429265 0.787048902484395 0.264705882352941 12.3 12 3 abnormal nervous system development 0.495727466648593 0.902724797429265 0.787048902484395 0.264705882352941 12.3 12 3 absent vitelline blood vessels 0.471135745249545 0.875242842649921 0.782446277323668 0.263157894736842 12.3 12 3 increased grooming behavior 0.49698699475443 0.90402570343813 0.782446277323668 0.263157894736842 12.3 12 3 abnormal retinal outer nuclear layer morphology 0.49698699475443 0.90402570343813 0.782446277323668 0.263157894736842 12.3 12 3 decreased threshold for auditory brainstem response 0.49698699475443 0.90402570343813 0.782446277323668 0.263157894736842 12.3 12 3 kyphoscoliosis 0.541390949754441 0.958325043325224 0.782446277323668 0.263157894736842 12.3 12 3 abnormal triglyceride level 0.541390949754441 0.958325043325224 0.782446277323668 0.263157894736842 12.3 12 3 irregular coat pigmentation 0.541390949754441 0.958325043325224 0.782446277323668 0.263157894736842 12.3 12 3 abnormal digestive system development 0.541390949754441 0.958325043325224 0.782446277323668 0.263157894736842 12.3 12 3 abnormal optic vesicle formation 0.541390949754441 0.958325043325224 0.782446277323668 0.263157894736842 12.3 12 3 absent amnion 0.541390949754441 0.958325043325224 0.782446277323668 0.263157894736842 12.3 12 3 abnormal behavioral response to xenobiotic 0.541390949754441 0.958325043325224 0.782446277323668 0.263157894736842 12.3 12 3 decreased liver glycogen level 0.541390949754441 0.958325043325224 0.782446277323668 0.263157894736842 12.3 12 3 thin interventricular septum 0.541390949754441 0.958325043325224 0.782446277323668 0.263157894736842 12.3 12 3 bidirectional circling 0.539019030772785 0.958325043325224 0.775642396651288 0.260869565217391 12.3 12 3 abnormal nasal cavity morphology 0.539019030772785 0.958325043325224 0.775642396651288 0.260869565217391 12.3 12 3 abnormal cardiovascular development 0.539019030772785 0.958325043325224 0.775642396651288 0.260869565217391 12.3 12 3 decreased epididymis weight 0.539019030772785 0.958325043325224 0.775642396651288 0.260869565217391 12.3 12 3 abnormal ulna morphology 0.539019030772785 0.958325043325224 0.775642396651288 0.260869565217391 12.3 12 3 abnormal corneal stroma morphology 0.539019030772785 0.958325043325224 0.775642396651288 0.260869565217391 12.3 12 3 abnormal mandible morphology 0.500897330598435 0.910805635865211 0.770854480622576 0.259259259259259 12.3 12 3 abnormal brain commissure morphology 0.537275378828743 0.958325043325224 0.770854480622576 0.259259259259259 12.3 12 3 decreased susceptibility to bacterial infection induced morbidity/mortality 0.535949319243474 0.958325043325224 0.767302155827081 0.258064516129032 12.3 12 3 abnormal tail morphology 0.503122569799084 0.914517641487192 0.765848932047105 0.257575757575758 12.3 12 3 impaired fertilization 0.503778802974101 0.915376020743664 0.764561790984841 0.257142857142857 12.3 12 3 decreased bone mineralization 0.534916161527539 0.958325043325224 0.764561790984841 0.257142857142857 12.3 12 3 abnormal iris morphology 0.53409697529035 0.958325043325224 0.762383552264086 0.256410256410256 12.3 12 3 increased vascular permeability 0.53409697529035 0.958325043325224 0.762383552264086 0.256410256410256 12.3 12 3 abnormal blood circulation 0.533439156062656 0.958325043325224 0.760610567258821 0.255813953488372 12.3 12 3 increased kidney weight 0.532471861921554 0.958325043325224 0.757898943133121 0.254901960784314 12.3 12 3 abnormal kidney development 0.561396308106911 0.958325043325224 0.743323963457484 0.25 12.3 12 3 decreased kidney weight 0.564203627975396 0.958325043325224 0.743323963457484 0.25 12.3 12 3 decreased circulating progesterone level 0.58025475693314 0.958325043325224 0.743323963457484 0.25 12.3 12 3 abnormal eye physiology 0.561396308106911 0.958325043325224 0.743323963457484 0.25 12.3 12 3 increased percent body fat/body weight 0.564203627975396 0.958325043325224 0.743323963457484 0.25 12.3 12 3 abnormal foregut morphology 0.585341281977273 0.963305616221282 0.743323963457484 0.25 12.3 12 3 abnormal adrenal gland morphology 0.585341281977273 0.963305616221282 0.743323963457484 0.25 12.3 12 3 apnea 0.585341281977273 0.963305616221282 0.743323963457484 0.25 12.3 12 3 abnormal impulse conducting system conduction 0.585341281977273 0.963305616221282 0.743323963457484 0.25 12.3 12 3 decreased ovulation rate 0.585341281977273 0.963305616221282 0.743323963457484 0.25 12.3 12 3 decreased fatty acid level 0.585341281977273 0.963305616221282 0.743323963457484 0.25 12.3 12 3 head bobbing 0.570198409830239 0.958325043325224 0.743323963457484 0.25 12.3 12 3 abnormal skin pigmentation 0.570198409830239 0.958325043325224 0.743323963457484 0.25 12.3 12 3 waved hair 0.591980988804111 0.972302878606951 0.743323963457484 0.25 12.3 12 3 abnormal lens epithelium morphology 0.591980988804111 0.972302878606951 0.743323963457484 0.25 12.3 12 3 abnormal male reproductive system physiology 0.591980988804111 0.972302878606951 0.743323963457484 0.25 12.3 12 3 decreased circulating VLDL cholesterol level 0.591980988804111 0.972302878606951 0.743323963457484 0.25 12.3 12 3 enhanced behavioral response to xenobiotic 0.591980988804111 0.972302878606951 0.743323963457484 0.25 12.3 12 3 decreased muscle cell glucose uptake 0.591980988804111 0.972302878606951 0.743323963457484 0.25 12.3 12 3 polyuria 0.583229086123561 0.961738383647569 0.733670405490504 0.246753246753247 12.3 12 3 short humerus 0.605056920429719 0.989858000374171 0.725194110690229 0.24390243902439 12.3 12 3 abnormal excitatory postsynaptic potential 0.606460317681951 0.991827771356906 0.725194110690229 0.24390243902439 12.3 12 3 abnormal breathing pattern 0.60950637202691 0.996154468079461 0.723234126607282 0.243243243243243 12.3 12 3 impaired skeletal muscle contractility 0.60950637202691 0.996154468079461 0.723234126607282 0.243243243243243 12.3 12 3 head tossing 0.614790726443207 0.999863963404693 0.720798994867863 0.242424242424242 12.3 12 3 impaired righting response 0.62396444974211 1 0.719850575137774 0.242105263157895 12.3 12 3 abnormal middle ear morphology 0.621188540910473 1 0.717692102648605 0.241379310344828 12.3 12 3 abnormal parietal bone morphology 0.621188540910473 1 0.717692102648605 0.241379310344828 12.3 12 3 abnormal osteoblast physiology 0.624933159215162 1 0.715793446292392 0.240740740740741 12.3 12 3 abnormal nest building behavior 0.629127136418091 1 0.713591004919185 0.24 12.3 12 3 diaphragmatic hernia 0.629127136418091 1 0.713591004919185 0.24 12.3 12 3 decreased placenta weight 0.629127136418091 1 0.713591004919185 0.24 12.3 12 3 increased liver glycogen level 0.629127136418091 1 0.713591004919185 0.24 12.3 12 3 abnormal stomach mucosa morphology 0.629127136418091 1 0.713591004919185 0.24 12.3 12 3 small ears 0.639302834335951 1 0.707927584245223 0.238095238095238 12.3 12 3 abnormal nervous system electrophysiology 0.653691163684433 1 0.707927584245223 0.238095238095238 12.3 12 3 increased vasoconstriction 0.639302834335951 1 0.707927584245223 0.238095238095238 12.3 12 3 hypoalgesia 0.639302834335951 1 0.707927584245223 0.238095238095238 12.3 12 3 dry skin 0.639302834335951 1 0.707927584245223 0.238095238095238 12.3 12 3 complete atrioventricular septal defect 0.639302834335951 1 0.707927584245223 0.238095238095238 12.3 12 3 impaired branching involved in ureteric bud morphogenesis 0.644426178766646 1 0.704201649591301 0.236842105263158 12.3 12 3 abnormal retinal photoreceptor morphology 0.65142557561078 1 0.699599024430573 0.235294117647059 12.3 12 3 increased systemic arterial blood pressure 0.664041708943375 1 0.695877753024028 0.234042553191489 12.3 12 3 abnormal heart tube morphology 0.659810487724779 1 0.693769032560319 0.233333333333333 12.3 12 3 abnormal response to new environment 0.659810487724779 1 0.693769032560319 0.233333333333333 12.3 12 3 abnormal estrous cycle 0.659810487724779 1 0.693769032560319 0.233333333333333 12.3 12 3 short mandible 0.681159015149885 1 0.690229394639092 0.232142857142857 12.3 12 3 abnormal eye electrophysiology 0.728659778006646 1 0.688035404192051 0.231404958677686 12.3 12 3 abnormal Schwann cell morphology 0.670083940807609 1 0.686145197037678 0.230769230769231 12.3 12 3 small seminal vesicle 0.670083940807609 1 0.686145197037678 0.230769230769231 12.3 12 3 abnormal long bone morphology 0.701616219227529 1 0.682395769731461 0.229508196721311 12.3 12 3 abnormal hair shaft morphology 0.693214926651899 1 0.681380299836027 0.229166666666667 12.3 12 3 dehydration 0.715012648540199 1 0.679610480875414 0.228571428571429 12.3 12 3 abnormal circulating amino acid level 0.707346220625118 1 0.678120107013845 0.228070175438596 12.3 12 3 abnormal tracheal cartilage morphology 0.683046420525613 1 0.675749057688622 0.227272727272727 12.3 12 3 abnormal channel response 0.683046420525613 1 0.675749057688622 0.227272727272727 12.3 12 3 abnormal circulating lipid level 0.683046420525613 1 0.675749057688622 0.227272727272727 12.3 12 3 cleft upper lip 0.683046420525613 1 0.675749057688622 0.227272727272727 12.3 12 3 abnormal occipital bone morphology 0.683046420525613 1 0.675749057688622 0.227272727272727 12.3 12 3 impaired swimming 0.720226707639488 1 0.675749057688622 0.227272727272727 12.3 12 3 abnormal limb morphology 0.732072806039365 1 0.673947060201452 0.226666666666667 12.3 12 3 increased susceptibility to weight loss 0.708684254964814 1 0.668991567111736 0.225 12.3 12 3 renal hypoplasia 0.718237075232427 1 0.660732411962208 0.222222222222222 12.3 12 3 cryptorchism 0.708029244230143 1 0.660732411962208 0.222222222222222 12.3 12 3 abnormal inhibitory postsynaptic currents 0.764230887511623 1 0.655874085403663 0.220588235294118 12.3 12 3 syndactyly 0.755584790703749 1 0.655132984742189 0.220338983050847 12.3 12 3 abnormal lymphatic vessel morphology 0.729457675508093 1 0.650408468025299 0.21875 12.3 12 3 abnormal long term potentiation 0.729457675508093 1 0.650408468025299 0.21875 12.3 12 3 abnormal diaphragm morphology 0.729457675508093 1 0.650408468025299 0.21875 12.3 12 3 increased susceptibility to pharmacologically induced seizures 0.804353914037557 1 0.650408468025299 0.21875 12.3 12 3 abnormal inner ear morphology 0.755273447605335 1 0.646368663876073 0.217391304347826 12.3 12 3 fragile skeleton 0.723054028790288 1 0.646368663876073 0.217391304347826 12.3 12 3 hypotension 0.723054028790288 1 0.646368663876073 0.217391304347826 12.3 12 3 abnormal hepatocyte physiology 0.723054028790288 1 0.646368663876073 0.217391304347826 12.3 12 3 increased insulin secretion 0.748231751978776 1 0.642874779206473 0.216216216216216 12.3 12 3 abnormal circulating cholesterol level 0.742876831674781 1 0.637134825820701 0.214285714285714 12.3 12 3 abnormal hormone level 0.742876831674781 1 0.637134825820701 0.214285714285714 12.3 12 3 dextrocardia 0.760329546410179 1 0.63069912050938 0.212121212121212 12.3 12 3 increased susceptibility to injury 0.793531263615445 1 0.628966430617871 0.211538461538462 12.3 12 3 abnormal axon guidance 0.789970844991256 1 0.622317736848126 0.209302325581395 12.3 12 3 abnormal digit morphology 0.837495112878879 1 0.61943663621457 0.208333333333333 12.3 12 3 abnormal osteoblast morphology 0.759294225320029 1 0.61943663621457 0.208333333333333 12.3 12 3 abnormal phalanx morphology 0.802750607854632 1 0.61943663621457 0.208333333333333 12.3 12 3 hypopigmentation 0.759294225320029 1 0.61943663621457 0.208333333333333 12.3 12 3 aphagia 0.774621603178513 1 0.61516465941309 0.206896551724138 12.3 12 3 decreased pancreatic beta cell number 0.788563909210022 1 0.612149146376752 0.205882352941176 12.3 12 3 hypertension 0.812995255228228 1 0.60817415191976 0.204545454545455 12.3 12 3 abnormal photoreceptor outer segment morphology 0.812995255228228 1 0.60817415191976 0.204545454545455 12.3 12 3 abnormal food intake 0.859531495283898 1 0.603277419617668 0.202898550724638 12.3 12 3 abnormal inner ear vestibule morphology 0.791835997545514 1 0.594659170765987 0.2 12.3 12 3 abnormal digestive system physiology 0.84302933489999 1 0.594659170765987 0.2 12.3 12 3 abnormal pain threshold 0.803324382041947 1 0.594659170765987 0.2 12.3 12 3 abnormal synaptic transmission 0.803324382041947 1 0.594659170765987 0.2 12.3 12 3 abnormal vertebrae development 0.791835997545514 1 0.594659170765987 0.2 12.3 12 3 abnormal energy expenditure 0.791835997545514 1 0.594659170765987 0.2 12.3 12 3 short radius 0.837386015049598 1 0.578140860466932 0.194444444444444 12.3 12 3 abnormal body temperature homeostasis 0.829097434884375 1 0.57547661687031 0.193548387096774 12.3 12 3 abnormal kidney cortex morphology 0.82082458248311 1 0.571787664198065 0.192307692307692 12.3 12 3 abnormal tectorial membrane morphology 0.82082458248311 1 0.571787664198065 0.192307692307692 12.3 12 3 abnormal tibia morphology 0.870570947458895 1 0.569354525201477 0.191489361702128 12.3 12 3 abnormal humerus morphology 0.85818867643279 1 0.562515431805664 0.189189189189189 12.3 12 3 increased dopamine level 0.852091225509671 1 0.557492972593113 0.1875 12.3 12 3 abnormal cochlea morphology 0.904051410861702 1 0.55061034330184 0.185185185185185 12.3 12 3 decreased susceptibility to pharmacologically induced seizures 0.846459886631511 1 0.55061034330184 0.185185185185185 12.3 12 3 abnormal single cell response 0.846459886631511 1 0.55061034330184 0.185185185185185 12.3 12 3 abnormal middle ear ossicle morphology 0.872482709754003 1 0.540599246150898 0.181818181818182 12.3 12 3 short sternum 0.888635512656549 1 0.512637216177575 0.172413793103448 12.3 12 3 abnormal femur morphology 0.968490532147969 1 0.488153050628796 0.164179104477612 12.3 12 3 decreased urine osmolality 0.95017723813403 1 0.485436057768153 0.163265306122449 12.3 12 3 abnormal cartilage development 0.957769836009733 1 0.462512688373546 0.155555555555556 12.3 12 3 abnormal autopod morphology 0.957769836009733 1 0.462512688373546 0.155555555555556 12.3 12 3 abnormal excitatory postsynaptic currents 0.986888305724644 1 0.457430131358452 0.153846153846154 12.3 12 3 absent vibrissae 0.943905222416675 1 0.450499371792415 0.151515151515152 12.3 12 3 abnormal bone remodeling 0.953119000441865 1 0.437249390269108 0.147058823529412 12.3 12 3 short ulna 0.965448104146114 1 0.435116466414137 0.146341463414634 12.3 12 3 abnormal hindlimb morphology 0.981856298077935 1 0.416261419536191 0.14 12.3 12 3 abnormal reflex 0.967532163242627 1 0.41295775747638 0.138888888888889 12.3 12 3 abnormal thymocyte activation 7.84728783076098e-11 4.94180467823239e-09 2.1988684582744 1 12.2 12 2 abnormal positive T cell selection 8.46228387086395e-08 3.29419984459454e-06 2.1988684582744 1 12.2 12 2 elevated level of mitotic sister chromatid exchange 9.10417308931664e-05 0.00164678282670635 2.1988684582744 1 12.2 12 2 abnormal NK cell morphology 9.10417308931664e-05 0.00164678282670635 2.1988684582744 1 12.2 12 2 decreased susceptibility to autoimmune disorder 9.10417308931664e-05 0.00164678282670635 2.1988684582744 1 12.2 12 2 pleural effusion 9.10417308931664e-05 0.00164678282670635 2.1988684582744 1 12.2 12 2 abnormal macrophage activation involved in immune response 9.10417308931664e-05 0.00164678282670635 2.1988684582744 1 12.2 12 2 decreased mortality induced by ionizing radiation 0.000291362746433622 0.00457264878078004 2.1988684582744 1 12.2 12 2 increased cell nucleus count 0.000291362746433622 0.00457264878078004 2.1988684582744 1 12.2 12 2 heart hemorrhage 0.000291362746433622 0.00457264878078004 2.1988684582744 1 12.2 12 2 abnormal lymph node cortex morphology 0.000932393776161487 0.0113934079920703 2.1988684582744 1 12.2 12 2 abnormal leukocyte tethering or rolling 0.000932393776161487 0.0113934079920703 2.1988684582744 1 12.2 12 2 abnormal T cell clonal deletion 0.000932393776161487 0.0113934079920703 2.1988684582744 1 12.2 12 2 impaired granulocyte bactericidal activity 0.000932393776161487 0.0113934079920703 2.1988684582744 1 12.2 12 2 decreased lysosomal enzyme secretion 0.00298357212203976 0.0287660296650151 2.1988684582744 1 12.2 12 2 gastric polyps 0.00298357212203976 0.0287660296650151 2.1988684582744 1 12.2 12 2 abnormal T cell selection 0.00298357212203976 0.0287660296650151 2.1988684582744 1 12.2 12 2 abnormal mismatch repair 0.00298357212203976 0.0287660296650151 2.1988684582744 1 12.2 12 2 decreased DN3 thymocyte number 0.00298357212203976 0.0287660296650151 2.1988684582744 1 12.2 12 2 increased T follicular helper cell number 0.00298357212203976 0.0287660296650151 2.1988684582744 1 12.2 12 2 aorta hypoplasia 0.00298357212203976 0.0287660296650151 2.1988684582744 1 12.2 12 2 increased regulatory T cell number 9.90792670489962e-08 3.76274315701341e-06 2.06952325484649 0.941176470588235 12.2 12 2 decreased response to antigen 2.69286298805293e-06 7.16416757516755e-05 2.04180642554051 0.928571428571429 12.2 12 2 absent inguinal lymph nodes 0.000204472898755412 0.00340218284718454 1.97898161244696 0.9 12.2 12 2 acanthocytosis 0.000204472898755412 0.00340218284718454 1.97898161244696 0.9 12.2 12 2 lethality during fetal growth through weaning, complete penetrance 0.000204472898755412 0.00340218284718454 1.97898161244696 0.9 12.2 12 2 lymphoid hyperplasia 2.61476197530838e-10 1.54862390799514e-08 1.96327540917357 0.892857142857143 12.2 12 2 crypts of Lieberkuhn abscesses 0.000591808831423359 0.00780967887621011 1.95454974068835 0.888888888888889 12.2 12 2 liver hyperplasia 0.000591808831423359 0.00780967887621011 1.95454974068835 0.888888888888889 12.2 12 2 absent cervical lymph nodes 0.000591808831423359 0.00780967887621011 1.95454974068835 0.888888888888889 12.2 12 2 abnormal telomere morphology 0.000591808831423359 0.00780967887621011 1.95454974068835 0.888888888888889 12.2 12 2 increased myeloid cell number 0.000591808831423359 0.00780967887621011 1.95454974068835 0.888888888888889 12.2 12 2 decreased cytotoxic T cell cytolysis 7.58932938571555e-12 5.89951776467732e-10 1.94017805141859 0.882352941176471 12.2 12 2 abnormal cytotoxic T cell physiology 2.75915807618094e-14 2.92059817638302e-12 1.93709840371792 0.880952380952381 12.2 12 2 increased sensitivity to skin irradiation 0.00169360985521681 0.0186409491807603 1.9240099009901 0.875 12.2 12 2 colon polyps 0.00169360985521681 0.0186409491807603 1.9240099009901 0.875 12.2 12 2 abnormal extraembryonic tissue physiology 0.00169360985521681 0.0186409491807603 1.9240099009901 0.875 12.2 12 2 abnormal meiotic spindle morphology 0.00169360985521681 0.0186409491807603 1.9240099009901 0.875 12.2 12 2 small thymus medulla 0.00169360985521681 0.0186409491807603 1.9240099009901 0.875 12.2 12 2 increased brain apoptosis 0.00169360985521681 0.0186409491807603 1.9240099009901 0.875 12.2 12 2 lysosomal protein accumulation 4.00121431462389e-05 0.000815821361280896 1.88474439280663 0.857142857142857 12.2 12 2 decreased activated T cell number 0.00477857995452866 0.0423014862522778 1.88474439280663 0.857142857142857 12.2 12 2 abnormal gastrulation movements 0.00477857995452866 0.0423014862522778 1.88474439280663 0.857142857142857 12.2 12 2 abnormal negative T cell selection 0.00477857995452866 0.0423014862522778 1.88474439280663 0.857142857142857 12.2 12 2 abnormal MHC II cell surface expression on macrophages 0.00477857995452866 0.0423014862522778 1.88474439280663 0.857142857142857 12.2 12 2 absent popliteal lymph nodes 0.00477857995452866 0.0423014862522778 1.88474439280663 0.857142857142857 12.2 12 2 increased tumor latency 0.00477857995452866 0.0423014862522778 1.88474439280663 0.857142857142857 12.2 12 2 decreased DN2 thymocyte number 0.00477857995452866 0.0423014862522778 1.88474439280663 0.857142857142857 12.2 12 2 decreased DN4 thymocyte number 0.00477857995452866 0.0423014862522778 1.88474439280663 0.857142857142857 12.2 12 2 arteritis 0.00477857995452866 0.0423014862522778 1.88474439280663 0.857142857142857 12.2 12 2 ductus venosus stenosis 0.00477857995452866 0.0423014862522778 1.88474439280663 0.857142857142857 12.2 12 2 abnormal T cell activation 1.18173418399527e-20 2.93956378268822e-18 1.84229519477044 0.837837837837838 12.2 12 2 decreased cellular sensitivity to gamma-irradiation 7.64381074694351e-06 0.000181085516504971 1.83239038189533 0.833333333333333 12.2 12 2 increased effector memory CD4-positive, alpha-beta T cell number 7.64381074694351e-06 0.000181085516504971 1.83239038189533 0.833333333333333 12.2 12 2 interstitial pneumonia 0.000301088976488185 0.00471043288688278 1.83239038189533 0.833333333333333 12.2 12 2 absent ectoplacental cone 0.0132394638514311 0.091735839360543 1.83239038189533 0.833333333333333 12.2 12 2 abnormal lymph organ size 0.0132394638514311 0.091735839360543 1.83239038189533 0.833333333333333 12.2 12 2 abnormal cervical lymph node morphology 0.0132394638514311 0.091735839360543 1.83239038189533 0.833333333333333 12.2 12 2 liver cirrhosis 0.0132394638514311 0.091735839360543 1.83239038189533 0.833333333333333 12.2 12 2 extremity edema 0.0132394638514311 0.091735839360543 1.83239038189533 0.833333333333333 12.2 12 2 bile duct inflammation 0.0132394638514311 0.091735839360543 1.83239038189533 0.833333333333333 12.2 12 2 decreased liver function 0.0132394638514311 0.091735839360543 1.83239038189533 0.833333333333333 12.2 12 2 rheumatoid arthritis 0.0132394638514311 0.091735839360543 1.83239038189533 0.833333333333333 12.2 12 2 abnormal cholesterol level 0.0132394638514311 0.091735839360543 1.83239038189533 0.833333333333333 12.2 12 2 decreased prostate gland weight 0.0132394638514311 0.091735839360543 1.83239038189533 0.833333333333333 12.2 12 2 decreased platelet ADP level 0.0132394638514311 0.091735839360543 1.83239038189533 0.833333333333333 12.2 12 2 absent brachial lymph nodes 0.0132394638514311 0.091735839360543 1.83239038189533 0.833333333333333 12.2 12 2 abnormal eyelid development 0.0132394638514311 0.091735839360543 1.83239038189533 0.833333333333333 12.2 12 2 delayed chorioallantoic fusion 0.0132394638514311 0.091735839360543 1.83239038189533 0.833333333333333 12.2 12 2 decreased DN1 thymic pro-T cell number 0.0132394638514311 0.091735839360543 1.83239038189533 0.833333333333333 12.2 12 2 absent third pharyngeal arch 0.0132394638514311 0.091735839360543 1.83239038189533 0.833333333333333 12.2 12 2 thymus cortex atrophy 0.0132394638514311 0.091735839360543 1.83239038189533 0.833333333333333 12.2 12 2 abnormal vertebral artery origin 0.0132394638514311 0.091735839360543 1.83239038189533 0.833333333333333 12.2 12 2 additional anastomosis between intracranial vertebral arteries 0.0132394638514311 0.091735839360543 1.83239038189533 0.833333333333333 12.2 12 2 increased B cell derived lymphoma incidence 1.79464343655785e-13 1.68459454658025e-11 1.80307213578501 0.82 12.2 12 2 abnormal lysosome physiology 1.45212244945308e-06 4.20017975931922e-05 1.7990741931336 0.818181818181818 12.2 12 2 abnormal thrombopoiesis 0.000809621049737636 0.0102751651082774 1.7990741931336 0.818181818181818 12.2 12 2 delayed hepatic development 0.000809621049737636 0.0102751651082774 1.7990741931336 0.818181818181818 12.2 12 2 vasculitis 0.000809621049737636 0.0102751651082774 1.7990741931336 0.818181818181818 12.2 12 2 loss of cortex neurons 0.000809621049737636 0.0102751651082774 1.7990741931336 0.818181818181818 12.2 12 2 decreased double-positive T cell number 1.25517313395029e-24 5.20373861783559e-22 1.78108345120226 0.81 12.2 12 2 abnormal T cell proliferation 2.02145535265168e-08 9.12122385520703e-07 1.77328101473742 0.806451612903226 12.2 12 2 increased double-negative T cell number 3.6812234639514e-15 4.46685042272152e-13 1.76630417140075 0.80327868852459 12.2 12 2 abnormal immune cell physiology 0.00214115256209515 0.0221921541592153 1.75909476661952 0.8 12.2 12 2 abnormal gas homeostasis 0.00214115256209515 0.0221921541592153 1.75909476661952 0.8 12.2 12 2 absent axillary lymph nodes 0.00214115256209515 0.0221921541592153 1.75909476661952 0.8 12.2 12 2 increased fatty acid oxidation 0.00214115256209515 0.0221921541592153 1.75909476661952 0.8 12.2 12 2 arrested T cell differentiation 5.24535353262627e-08 2.15666395246411e-06 1.75909476661952 0.8 12.2 12 2 abnormal lymph node B cell domain morphology 0.000142657221936971 0.00246430444144594 1.75909476661952 0.8 12.2 12 2 decreased thymocyte apoptosis 0.000142657221936971 0.00246430444144594 1.75909476661952 0.8 12.2 12 2 decreased T cell proliferation 5.48854728986834e-34 3.90078896672785e-31 1.75315187889445 0.797297297297297 12.2 12 2 abnormal T cell subpopulation ratio 2.55442503183811e-08 1.114760046789e-06 1.73244181561013 0.787878787878788 12.2 12 2 abnormal cell nucleus morphology 2.76227420241078e-11 1.96318773671337e-09 1.73102410545006 0.787234042553192 12.2 12 2 abnormal NK cell physiology 3.10246132130935e-14 3.21557189031542e-12 1.73025714749461 0.786885245901639 12.2 12 2 abnormal antigen presentation 0.000368565533914004 0.00552293232295834 1.72768236007274 0.785714285714286 12.2 12 2 abnormal spleen periarteriolar lymphoid sheath morphology 0.000368565533914004 0.00552293232295834 1.72768236007274 0.785714285714286 12.2 12 2 increased hemangioma incidence 0.000368565533914004 0.00552293232295834 1.72768236007274 0.785714285714286 12.2 12 2 vascular smooth muscle hypoplasia 0.000368565533914004 0.00552293232295834 1.72768236007274 0.785714285714286 12.2 12 2 abnormal maternal decidual layer morphology 0.000368565533914004 0.00552293232295834 1.72768236007274 0.785714285714286 12.2 12 2 abnormal lymphocyte physiology 6.9950532888525e-11 4.51953118338197e-09 1.72085357604083 0.782608695652174 12.2 12 2 abnormal Peyer's patch follicle morphology 6.55470211032244e-05 0.00127381417964274 1.71023102310231 0.777777777777778 12.2 12 2 absent inner cell mass 6.55470211032244e-05 0.00127381417964274 1.71023102310231 0.777777777777778 12.2 12 2 increased effector memory CD8-positive, alpha-beta T cell number 6.55470211032244e-05 0.00127381417964274 1.71023102310231 0.777777777777778 12.2 12 2 increased pheochromocytoma incidence 0.0055499134384939 0.0471174391749268 1.71023102310231 0.777777777777778 12.2 12 2 abnormal artery development 0.0055499134384939 0.0471174391749268 1.71023102310231 0.777777777777778 12.2 12 2 abnormal thymus physiology 0.0055499134384939 0.0471174391749268 1.71023102310231 0.777777777777778 12.2 12 2 decreased cellular sensitivity to ionizing radiation 0.0055499134384939 0.0471174391749268 1.71023102310231 0.777777777777778 12.2 12 2 increased neuronal precursor cell number 0.0055499134384939 0.0471174391749268 1.71023102310231 0.777777777777778 12.2 12 2 abnormal leukopoiesis 0.0055499134384939 0.0471174391749268 1.71023102310231 0.777777777777778 12.2 12 2 decreased platelet dense granule number 0.0055499134384939 0.0471174391749268 1.71023102310231 0.777777777777778 12.2 12 2 spleen hyperplasia 2.75556522473775e-16 4.0320402920795e-14 1.70045827439887 0.773333333333333 12.2 12 2 increased activated T cell number 1.18943215300758e-05 0.000271441511982234 1.6991256268484 0.772727272727273 12.2 12 2 increased autoantibody level 5.78232007398339e-09 2.79291673476382e-07 1.69143727559569 0.769230769230769 12.2 12 2 decreased Peyer's patch number 2.18805570187469e-06 6.08132799822715e-05 1.69143727559569 0.769230769230769 12.2 12 2 abnormal telomere length 0.000936664094222461 0.0113934079920703 1.69143727559569 0.769230769230769 12.2 12 2 increased T cell proliferation 5.43352336784189e-22 1.80211858366756e-19 1.68511414559346 0.766355140186916 12.2 12 2 increased cellular sensitivity to gamma-irradiation 2.084778484448e-10 1.26485036099132e-08 1.68423967016762 0.765957446808511 12.2 12 2 decreased regulatory T cell number 7.60777314882468e-08 3.02789371323222e-06 1.68148764456278 0.764705882352941 12.2 12 2 increased mortality induced by gamma-irradiation 1.0043890296575e-06 2.97430679913455e-05 1.66810710627713 0.758620689655172 12.2 12 2 increased T cell derived lymphoma incidence 2.39332312187045e-10 1.43455211220548e-08 1.66037006032965 0.755102040816326 12.2 12 2 abnormal T cell differentiation 1.17219767240267e-19 2.65076519100148e-17 1.6545940874144 0.752475247524752 12.2 12 2 increased skin tumor incidence 7.29933430890899e-05 0.00138076761166624 1.6491513437058 0.75 12.2 12 2 increased fibroblast apoptosis 4.57589226256496e-07 1.58090722265699e-05 1.6491513437058 0.75 12.2 12 2 subcutaneous edema 2.45696011958263e-06 6.64313945376282e-05 1.6491513437058 0.75 12.2 12 2 abnormal tumor morphology 1.33106335990435e-05 0.000302376265549048 1.6491513437058 0.75 12.2 12 2 increased intestinal adenocarcinoma incidence 0.000407329505521493 0.00585683320800413 1.6491513437058 0.75 12.2 12 2 large intestinal inflammation 0.000407329505521493 0.00585683320800413 1.6491513437058 0.75 12.2 12 2 abnormal thymus involution 0.00233521726948599 0.0235653264009996 1.6491513437058 0.75 12.2 12 2 myocarditis 0.00233521726948599 0.0235653264009996 1.6491513437058 0.75 12.2 12 2 altered tumor susceptibility 0.00233521726948599 0.0235653264009996 1.6491513437058 0.75 12.2 12 2 decreased mammary gland epithelial cell proliferation 0.00233521726948599 0.0235653264009996 1.6491513437058 0.75 12.2 12 2 increased fibrosarcoma incidence 0.00233521726948599 0.0235653264009996 1.6491513437058 0.75 12.2 12 2 embryonic lethality between implantation and placentation, incomplete penetrance 0.00233521726948599 0.0235653264009996 1.6491513437058 0.75 12.2 12 2 abnormal atrial thrombosis 0.0140334902524643 0.0939658331171059 1.6491513437058 0.75 12.2 12 2 preneoplasia 0.0140334902524643 0.0939658331171059 1.6491513437058 0.75 12.2 12 2 abnormal hepatobiliary system morphology 0.0140334902524643 0.0939658331171059 1.6491513437058 0.75 12.2 12 2 abnormal soft palate morphology 0.0140334902524643 0.0939658331171059 1.6491513437058 0.75 12.2 12 2 abnormal eyelid aperture 0.0140334902524643 0.0939658331171059 1.6491513437058 0.75 12.2 12 2 binucleate 0.0140334902524643 0.0939658331171059 1.6491513437058 0.75 12.2 12 2 lymph node inflammation 0.0140334902524643 0.0939658331171059 1.6491513437058 0.75 12.2 12 2 abnormal kidney epithelium morphology 0.0140334902524643 0.0939658331171059 1.6491513437058 0.75 12.2 12 2 accumulation of giant lysosomes in kidney/renal tubule cells 0.0140334902524643 0.0939658331171059 1.6491513437058 0.75 12.2 12 2 craniofacial phenotype 0.0140334902524643 0.0939658331171059 1.6491513437058 0.75 12.2 12 2 enlarged inguinal lymph nodes 0.0140334902524643 0.0939658331171059 1.6491513437058 0.75 12.2 12 2 abnormal mitotic spindle assembly checkpoint 0.0140334902524643 0.0939658331171059 1.6491513437058 0.75 12.2 12 2 increased caudal vertebrae number 0.0140334902524643 0.0939658331171059 1.6491513437058 0.75 12.2 12 2 decreased quadriceps weight 0.0140334902524643 0.0939658331171059 1.6491513437058 0.75 12.2 12 2 lung situs inversus 0.0140334902524643 0.0939658331171059 1.6491513437058 0.75 12.2 12 2 increased aorta wall thickness 0.0140334902524643 0.0939658331171059 1.6491513437058 0.75 12.2 12 2 abnormal CD4-positive, alpha-beta T cell physiology 6.91514087856318e-14 6.74565213153957e-12 1.64140884913441 0.746478873239437 12.2 12 2 impaired macrophage chemotaxis 3.90810085157101e-08 1.6617779262022e-06 1.63505603307584 0.743589743589744 12.2 12 2 failure to gastrulate 3.36926001161378e-09 1.64334005468417e-07 1.62525059959412 0.739130434782609 12.2 12 2 impaired natural killer cell mediated cytotoxicity 5.60273165499403e-11 3.87133194216601e-09 1.62021886399166 0.736842105263158 12.2 12 2 increased metastatic potential 2.64860779369815e-06 7.08431385680015e-05 1.61250353606789 0.733333333333333 12.2 12 2 salivary gland inflammation 2.64860779369815e-06 7.08431385680015e-05 1.61250353606789 0.733333333333333 12.2 12 2 macrocytosis 0.000989813391850847 0.0116967259488313 1.61250353606789 0.733333333333333 12.2 12 2 immune system phenotype 0.000989813391850847 0.0116967259488313 1.61250353606789 0.733333333333333 12.2 12 2 abnormal dendritic cell morphology 0.000989813391850847 0.0116967259488313 1.61250353606789 0.733333333333333 12.2 12 2 increased embryonic tissue cell apoptosis 3.80361968414717e-14 3.86183835278207e-12 1.60686541181591 0.730769230769231 12.2 12 2 abnormal leukocyte cell number 1.42202931668837e-05 0.00031442648224554 1.60686541181591 0.730769230769231 12.2 12 2 decreased bone resorption 1.42202931668837e-05 0.00031442648224554 1.60686541181591 0.730769230769231 12.2 12 2 increased thymocyte apoptosis 1.42202931668837e-05 0.00031442648224554 1.60686541181591 0.730769230769231 12.2 12 2 increased B cell proliferation 6.02806883968441e-11 4.05265438884188e-09 1.60256514755592 0.728813559322034 12.2 12 2 impaired humoral immune response 7.70348809032593e-05 0.00144622087733477 1.5991770605632 0.727272727272727 12.2 12 2 abnormal sphenoid bone morphology 0.00569190326171517 0.048076772032314 1.5991770605632 0.727272727272727 12.2 12 2 abnormal dorsal-ventral polarity of the somites 0.00569190326171517 0.048076772032314 1.5991770605632 0.727272727272727 12.2 12 2 reduced sympathetic cervical ganglion size 0.00569190326171517 0.048076772032314 1.5991770605632 0.727272727272727 12.2 12 2 abnormal B cell differentiation 6.96603269687636e-16 9.1200033334105e-14 1.59478371699022 0.725274725274725 12.2 12 2 abnormal erythropoiesis 5.4552651886716e-18 1.04384401206312e-15 1.59156193170337 0.723809523809524 12.2 12 2 abnormal trophoblast giant cell morphology 5.23513208707359e-07 1.74797195524773e-05 1.58807166430929 0.722222222222222 12.2 12 2 abnormal radius morphology 0.000422423661820626 0.00590325201561128 1.58807166430929 0.722222222222222 12.2 12 2 abnormal thymus cortex morphology 0.000422423661820626 0.00590325201561128 1.58807166430929 0.722222222222222 12.2 12 2 abnormal thymus medulla morphology 0.000422423661820626 0.00590325201561128 1.58807166430929 0.722222222222222 12.2 12 2 abnormal bile duct morphology 0.000422423661820626 0.00590325201561128 1.58807166430929 0.722222222222222 12.2 12 2 abnormal hypoglossal nerve topology 0.000422423661820626 0.00590325201561128 1.58807166430929 0.722222222222222 12.2 12 2 abnormal cytokine secretion 2.36016784448114e-25 1.06743954784488e-22 1.58489869395103 0.720779220779221 12.2 12 2 decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 3.35815376390649e-05 0.000696117290643116 1.58318528995757 0.72 12.2 12 2 decreased B-1 B cell number 2.32542075305213e-07 8.32299873844197e-06 1.57867479055598 0.717948717948718 12.2 12 2 thymus hypoplasia 1.61484230598472e-22 5.7384574801957e-20 1.57744911137076 0.717391304347826 12.2 12 2 abnormal hematopoietic system physiology 0.000181326879232182 0.00304763927087874 1.57062032733886 0.714285714285714 12.2 12 2 increased B-1 B cell number 0.0023569104949936 0.0236403824850668 1.57062032733886 0.714285714285714 12.2 12 2 increased stomach tumor incidence 0.0023569104949936 0.0236403824850668 1.57062032733886 0.714285714285714 12.2 12 2 testis degeneration 0.0023569104949936 0.0236403824850668 1.57062032733886 0.714285714285714 12.2 12 2 polyphalangy 0.0343916735936873 0.18240786367654 1.57062032733886 0.714285714285714 12.2 12 2 mammary gland hyperplasia 0.0343916735936873 0.18240786367654 1.57062032733886 0.714285714285714 12.2 12 2 excessive tearing 0.0343916735936873 0.18240786367654 1.57062032733886 0.714285714285714 12.2 12 2 abnormal circulating alanine transaminase level 0.0343916735936873 0.18240786367654 1.57062032733886 0.714285714285714 12.2 12 2 abnormal tumor incidence 0.0343916735936873 0.18240786367654 1.57062032733886 0.714285714285714 12.2 12 2 abnormal hypersensitivity reaction 0.0343916735936873 0.18240786367654 1.57062032733886 0.714285714285714 12.2 12 2 abnormal lymph node primary follicle morphology 0.0343916735936873 0.18240786367654 1.57062032733886 0.714285714285714 12.2 12 2 decreased cardiomyocyte apoptosis 0.0343916735936873 0.18240786367654 1.57062032733886 0.714285714285714 12.2 12 2 abnormal sinus venosus morphology 0.0343916735936873 0.18240786367654 1.57062032733886 0.714285714285714 12.2 12 2 aorta coarctation 0.0343916735936873 0.18240786367654 1.57062032733886 0.714285714285714 12.2 12 2 decreased tidal volume 0.0343916735936873 0.18240786367654 1.57062032733886 0.714285714285714 12.2 12 2 abnormal uterus physiology 0.0343916735936873 0.18240786367654 1.57062032733886 0.714285714285714 12.2 12 2 abnormal sperm annulus morphology 0.0343916735936873 0.18240786367654 1.57062032733886 0.714285714285714 12.2 12 2 increased DN3 thymocyte number 0.0343916735936873 0.18240786367654 1.57062032733886 0.714285714285714 12.2 12 2 decreased brain cholesterol level 0.0343916735936873 0.18240786367654 1.57062032733886 0.714285714285714 12.2 12 2 decreased T-helper 17 cell number 0.0343916735936873 0.18240786367654 1.57062032733886 0.714285714285714 12.2 12 2 embryonic lethality at implantation, incomplete penetrance 0.0343916735936873 0.18240786367654 1.57062032733886 0.714285714285714 12.2 12 2 increased circulating lactate dehydrogenase level 0.0343916735936873 0.18240786367654 1.57062032733886 0.714285714285714 12.2 12 2 small tail bud 0.0343916735936873 0.18240786367654 1.57062032733886 0.714285714285714 12.2 12 2 decreased CD8-positive, naive alpha-beta T cell number 0.0343916735936873 0.18240786367654 1.57062032733886 0.714285714285714 12.2 12 2 abnormal Mullerian duct topology 0.0343916735936873 0.18240786367654 1.57062032733886 0.714285714285714 12.2 12 2 absent connection between subcutaneous lymph vessels and lymph sac 0.0343916735936873 0.18240786367654 1.57062032733886 0.714285714285714 12.2 12 2 autoimmune response 6.41804423363351e-06 0.000155754975913789 1.56048729296893 0.709677419354839 12.2 12 2 inner cell mass degeneration 6.41804423363351e-06 0.000155754975913789 1.56048729296893 0.709677419354839 12.2 12 2 abnormal CD8-positive, alpha beta T cell morphology 6.41804423363351e-06 0.000155754975913789 1.56048729296893 0.709677419354839 12.2 12 2 decreased B cell proliferation 5.26135170942551e-13 4.7591317735258e-11 1.55869156535907 0.708860759493671 12.2 12 2 vertebral transformation 2.03724621645238e-08 9.12122385520703e-07 1.55753182461103 0.708333333333333 12.2 12 2 increased hemangiosarcoma incidence 7.82127536365127e-05 0.00146281371932951 1.55753182461103 0.708333333333333 12.2 12 2 abnormal spleen red pulp morphology 2.81327398543525e-06 7.40531115213776e-05 1.55214244113487 0.705882352941177 12.2 12 2 abnormal embryonic-extraembryonic boundary morphology 0.00098968970764707 0.0116967259488313 1.55214244113487 0.705882352941177 12.2 12 2 pancytopenia 0.00098968970764707 0.0116967259488313 1.55214244113487 0.705882352941177 12.2 12 2 small liver 1.20115539606872e-12 1.03030139576584e-10 1.55048416929605 0.705128205128205 12.2 12 2 enlarged spleen 8.92578354369972e-43 1.11014432824765e-39 1.54989686468647 0.704861111111111 12.2 12 2 embryonic lethality before implantation, complete penetrance 2.65315118692266e-19 5.73888137171315e-17 1.54800339462518 0.704 12.2 12 2 abnormal Peyer's patch T cell area morphology 0.000419791587768101 0.00590325201561128 1.53920792079208 0.7 12.2 12 2 spleen atrophy 0.000419791587768101 0.00590325201561128 1.53920792079208 0.7 12.2 12 2 enlarged testis 0.0135036888167577 0.0929195738082563 1.53920792079208 0.7 12.2 12 2 bifid ureter 0.0135036888167577 0.0929195738082563 1.53920792079208 0.7 12.2 12 2 absent CD4-positive, alpha beta T cells 0.0135036888167577 0.0929195738082563 1.53920792079208 0.7 12.2 12 2 abnormal left subclavian artery morphology 0.0135036888167577 0.0929195738082563 1.53920792079208 0.7 12.2 12 2 thick aortic valve cusps 0.0135036888167577 0.0929195738082563 1.53920792079208 0.7 12.2 12 2 abnormal spleen marginal zone morphology 1.4719779250158e-05 0.000324030538803256 1.53920792079208 0.7 12.2 12 2 extramedullary hematopoiesis 3.83327955530692e-16 5.15420696963566e-14 1.53505911238024 0.69811320754717 12.2 12 2 abnormal regulatory T cell physiology 0.000179422223287915 0.00303614136346047 1.52964762314741 0.695652173913043 12.2 12 2 abnormal lysosome morphology 2.80282802768832e-06 7.40531115213776e-05 1.52699198491278 0.694444444444444 12.2 12 2 decreased IgG level 1.72296007314071e-16 2.59749283753789e-14 1.52534118276693 0.693693693693694 12.2 12 2 increased T cell number 2.43765170774954e-13 2.24579949000999e-11 1.5242156358493 0.693181818181818 12.2 12 2 abnormal leukocyte migration 2.05342124981545e-08 9.12122385520703e-07 1.52229354803612 0.692307692307692 12.2 12 2 abnormal mast cell morphology 0.00548196191382893 0.0471174391749268 1.52229354803612 0.692307692307692 12.2 12 2 increased foot pad pigmentation 0.00548196191382893 0.0471174391749268 1.52229354803612 0.692307692307692 12.2 12 2 lymphoid hypoplasia 0.00548196191382893 0.0471174391749268 1.52229354803612 0.692307692307692 12.2 12 2 abnormal T-helper 2 physiology 9.07689498244181e-09 4.30071928929981e-07 1.51921820753504 0.690909090909091 12.2 12 2 abnormal spleen white pulp morphology 5.38321061039001e-07 1.77360746931724e-05 1.51826631642756 0.69047619047619 12.2 12 2 disorganized yolk sac vascular plexus 0.00227127794177542 0.0232024800006832 1.51172206506365 0.6875 12.2 12 2 blepharitis 0.00227127794177542 0.0232024800006832 1.51172206506365 0.6875 12.2 12 2 abnormal cell cycle 1.70617997326516e-16 2.59749283753789e-14 1.51052702785807 0.68695652173913 12.2 12 2 abnormal apoptosis 2.02240435434276e-08 9.12122385520703e-07 1.50663209178061 0.685185185185185 12.2 12 2 altered susceptibility to infection 0.0009541038266976 0.0114650068044051 1.50448894513512 0.684210526315789 12.2 12 2 decreased tumor incidence 0.0009541038266976 0.0114650068044051 1.50448894513512 0.684210526315789 12.2 12 2 embryonic lethality between implantation and somite formation, incomplete penetrance 0.0009541038266976 0.0114650068044051 1.50448894513512 0.684210526315789 12.2 12 2 abnormal cell morphology 3.77635398366776e-16 5.15420696963566e-14 1.50448894513511 0.684210526315789 12.2 12 2 abnormal abdominal fat pad morphology 0.000404809732794159 0.00585444308328762 1.499228494278 0.681818181818182 12.2 12 2 abnormal vascular branching morphogenesis 0.000404809732794159 0.00585444308328762 1.499228494278 0.681818181818182 12.2 12 2 increased adenoma incidence 0.000404809732794159 0.00585444308328762 1.499228494278 0.681818181818182 12.2 12 2 increased bone volume 0.000404809732794159 0.00585444308328762 1.499228494278 0.681818181818182 12.2 12 2 hydrops fetalis 1.51621928221972e-10 9.42898866130387e-09 1.49645214521452 0.680555555555556 12.2 12 2 abnormal mitotic spindle morphology 7.44175994928343e-05 0.00140237711165474 1.49208931097191 0.678571428571429 12.2 12 2 increased tumor incidence 7.19545207835011e-17 1.23439220999282e-14 1.48955605237943 0.67741935483871 12.2 12 2 abnormal direction of heart looping 1.39464960186833e-05 0.000313953926212441 1.48746983942092 0.676470588235294 12.2 12 2 abnormal chromosome morphology 6.06887290350523e-06 0.000150212152711137 1.48572193126649 0.675675675675676 12.2 12 2 embryonic lethality between implantation and placentation, complete penetrance 5.07574132370574e-07 1.71400527558548e-05 1.48184613492405 0.673913043478261 12.2 12 2 embryonic lethality between somite formation and embryo turning, complete penetrance 7.24927650046655e-10 4.05226411121586e-08 1.47638310769852 0.671428571428571 12.2 12 2 abnormal spleen morphology 7.60928835799368e-22 2.28277668461068e-19 1.46591230551627 0.666666666666667 12.2 12 2 increased lymphocyte cell number 1.56948312027515e-09 8.30657289720094e-08 1.46591230551627 0.666666666666667 12.2 12 2 abnormal lymph node morphology 4.84577524147988e-07 1.66260219492155e-05 1.46591230551627 0.666666666666667 12.2 12 2 abnormal leukocyte adhesion 5.77848003407894e-06 0.00014511619073255 1.46591230551627 0.666666666666667 12.2 12 2 liver hemorrhage 7.05436728699182e-05 0.00136028981599939 1.46591230551627 0.666666666666667 12.2 12 2 small lymph nodes 0.000381841162590723 0.00567062622056372 1.46591230551627 0.666666666666667 12.2 12 2 increased incidence of induced tumors 0.000896721004839938 0.0110699429257536 1.46591230551627 0.666666666666667 12.2 12 2 left pulmonary isomerism 0.000896721004839938 0.0110699429257536 1.46591230551627 0.666666666666667 12.2 12 2 embryonic lethality at implantation, complete penetrance 0.000896721004839938 0.0110699429257536 1.46591230551627 0.666666666666667 12.2 12 2 increased muscle cell glucose uptake 0.000896721004839938 0.0110699429257536 1.46591230551627 0.666666666666667 12.2 12 2 abnormal megakaryocyte differentiation 0.00212422179929996 0.0221921541592153 1.46591230551627 0.666666666666667 12.2 12 2 increased susceptibility to autoimmune disorder 0.00212422179929996 0.0221921541592153 1.46591230551627 0.666666666666667 12.2 12 2 increased gastrointestinal tumor incidence 0.00212422179929996 0.0221921541592153 1.46591230551627 0.666666666666667 12.2 12 2 impaired leukocyte tethering or rolling 0.00212422179929996 0.0221921541592153 1.46591230551627 0.666666666666667 12.2 12 2 delayed intramembranous bone ossification 0.0050911047012791 0.0445919821987034 1.46591230551627 0.666666666666667 12.2 12 2 abnormal placenta size 0.0050911047012791 0.0445919821987034 1.46591230551627 0.666666666666667 12.2 12 2 abnormal trophectoderm morphology 0.0050911047012791 0.0445919821987034 1.46591230551627 0.666666666666667 12.2 12 2 amyloidosis 0.0124052752461735 0.0885834308244574 1.46591230551627 0.666666666666667 12.2 12 2 abnormal embryonic growth/weight/body size 0.0124052752461735 0.0885834308244574 1.46591230551627 0.666666666666667 12.2 12 2 abnormal gastrocnemius morphology 0.0124052752461735 0.0885834308244574 1.46591230551627 0.666666666666667 12.2 12 2 loss of dopaminergic neurons 0.0124052752461735 0.0885834308244574 1.46591230551627 0.666666666666667 12.2 12 2 abnormal B cell proliferation 0.0124052752461735 0.0885834308244574 1.46591230551627 0.666666666666667 12.2 12 2 abnormal thymus corticomedullary boundary morphology 0.0124052752461735 0.0885834308244574 1.46591230551627 0.666666666666667 12.2 12 2 persistent right dorsal aorta 0.0124052752461735 0.0885834308244574 1.46591230551627 0.666666666666667 12.2 12 2 prenatal growth retardation 0.0124052752461735 0.0885834308244574 1.46591230551627 0.666666666666667 12.2 12 2 abnormal vitelline vein connection 0.0124052752461735 0.0885834308244574 1.46591230551627 0.666666666666667 12.2 12 2 heart hyperplasia 0.031000643880405 0.171746328847455 1.46591230551627 0.666666666666667 12.2 12 2 abnormal kindling response 0.031000643880405 0.171746328847455 1.46591230551627 0.666666666666667 12.2 12 2 multifocal hepatic necrosis 0.031000643880405 0.171746328847455 1.46591230551627 0.666666666666667 12.2 12 2 decreased level of surface class I molecules 0.031000643880405 0.171746328847455 1.46591230551627 0.666666666666667 12.2 12 2 abnormal thymus lobule morphology 0.031000643880405 0.171746328847455 1.46591230551627 0.666666666666667 12.2 12 2 abnormal gut-associated lymphoid tissue morphology 0.031000643880405 0.171746328847455 1.46591230551627 0.666666666666667 12.2 12 2 decreased cochlear hair cell number 0.031000643880405 0.171746328847455 1.46591230551627 0.666666666666667 12.2 12 2 abnormal liver vasculature morphology 0.031000643880405 0.171746328847455 1.46591230551627 0.666666666666667 12.2 12 2 axonal spheroids 0.031000643880405 0.171746328847455 1.46591230551627 0.666666666666667 12.2 12 2 decreased susceptibility to parasitic infection induced morbidity/mortality 0.031000643880405 0.171746328847455 1.46591230551627 0.666666666666667 12.2 12 2 cerebellum atrophy 0.031000643880405 0.171746328847455 1.46591230551627 0.666666666666667 12.2 12 2 increased bone mineralization 0.031000643880405 0.171746328847455 1.46591230551627 0.666666666666667 12.2 12 2 increased endoplasmic reticulum stress 0.031000643880405 0.171746328847455 1.46591230551627 0.666666666666667 12.2 12 2 abnormal definitive hematopoiesis 2.34545104893534e-12 1.91288835548415e-10 1.46591230551627 0.666666666666667 12.2 12 2 embryonic lethality between implantation and somite formation, complete penetrance 2.66314410253698e-29 1.32491419101215e-26 1.45394567445083 0.661224489795918 12.2 12 2 increased monocyte cell number 9.45712488100589e-13 8.25424496193058e-11 1.4512531824611 0.66 12.2 12 2 muscular atrophy 2.38047970214863e-06 6.50708050449968e-05 1.4492542111354 0.659090909090909 12.2 12 2 abnormal response to infection 2.77418935111624e-10 1.60483628160503e-08 1.44735645354771 0.658227848101266 12.2 12 2 increased B cell number 1.56351038836411e-14 1.76783276866169e-12 1.44711855800965 0.658119658119658 12.2 12 2 decreased B cell number 4.20407433046525e-24 1.60886690723574e-21 1.4410060284808 0.655339805825243 12.2 12 2 abnormal CD8-positive, alpha-beta T cell physiology 0.00015248832532807 0.00262501528895207 1.44063795542116 0.655172413793103 12.2 12 2 increased sarcoma incidence 9.77274189338732e-07 2.95180498073355e-05 1.43599572785267 0.653061224489796 12.2 12 2 decreased T cell number 7.62875848621673e-19 1.58137806120534e-16 1.4340446467007 0.652173913043478 12.2 12 2 abnormal immune system morphology 2.22482781895978e-06 6.14917688851384e-05 1.43404464670069 0.652173913043478 12.2 12 2 failure of embryo implantation 0.000827411313118363 0.0104211931209212 1.43404464670069 0.652173913043478 12.2 12 2 conjunctivitis 0.000827411313118363 0.0104211931209212 1.43404464670069 0.652173913043478 12.2 12 2 abnormal physiological neovascularization 0.00194639798470953 0.0207796780556436 1.42926449787836 0.65 12.2 12 2 decreased IgM level 8.96530601583934e-12 6.75793900436374e-10 1.42813106052873 0.649484536082474 12.2 12 2 decreased cell proliferation 4.98306719564719e-21 1.34246929875371e-18 1.42629305401583 0.648648648648649 12.2 12 2 increased granulocyte number 2.79795579441853e-09 1.40121872618635e-07 1.42629305401583 0.648648648648649 12.2 12 2 decreased lymphocyte cell number 5.45346699856887e-15 6.45976150425717e-13 1.42582876591231 0.6484375 12.2 12 2 increased lung adenocarcinoma incidence 9.08262114778921e-07 2.84188932139945e-05 1.42279723770696 0.647058823529412 12.2 12 2 abnormal bone marrow cavity morphology 0.00462085637101073 0.0417218882863492 1.42279723770696 0.647058823529412 12.2 12 2 abnormal ectoplacental cone morphology 0.00462085637101073 0.0417218882863492 1.42279723770696 0.647058823529412 12.2 12 2 abnormal tarsal bone morphology 0.00462085637101073 0.0417218882863492 1.42279723770696 0.647058823529412 12.2 12 2 increased brain size 0.00462085637101073 0.0417218882863492 1.42279723770696 0.647058823529412 12.2 12 2 decreased double-negative T cell number 0.000140344127570026 0.00244130082049259 1.41862481178993 0.645161290322581 12.2 12 2 premature aging 0.000324373708202683 0.00504299749471359 1.41355829460497 0.642857142857143 12.2 12 2 failure of zygotic cell division 0.0111070544677325 0.081762078668612 1.41355829460497 0.642857142857143 12.2 12 2 abnormal viscerocranium morphology 0.0111070544677325 0.081762078668612 1.41355829460497 0.642857142857143 12.2 12 2 abnormal vitelline vein topology 0.0111070544677325 0.081762078668612 1.41355829460497 0.642857142857143 12.2 12 2 thrombocytopenia 3.65264122657654e-16 5.15420696963566e-14 1.41030873530703 0.641379310344828 12.2 12 2 abnormal myelopoiesis 9.78630397128694e-06 0.000228576818108697 1.3992799279928 0.636363636363636 12.2 12 2 abnormal germ layer development 0.00175756573092004 0.0190914618151249 1.3992799279928 0.636363636363636 12.2 12 2 intestinal inflammation 0.00175756573092004 0.0190914618151249 1.3992799279928 0.636363636363636 12.2 12 2 abnormal mesenteric lymph node morphology 0.00175756573092004 0.0190914618151249 1.3992799279928 0.636363636363636 12.2 12 2 abnormal occipital bone morphology 0.00175756573092004 0.0190914618151249 1.3992799279928 0.636363636363636 12.2 12 2 abnormal large intestine morphology 0.027174313538082 0.164267569686462 1.3992799279928 0.636363636363636 12.2 12 2 abnormal proximal-distal axis patterning 0.027174313538082 0.164267569686462 1.3992799279928 0.636363636363636 12.2 12 2 pharyngeal arch hypoplasia 0.027174313538082 0.164267569686462 1.3992799279928 0.636363636363636 12.2 12 2 decreased circulating total protein level 7.69594420417937e-07 2.45431553947387e-05 1.3992799279928 0.636363636363636 12.2 12 2 preweaning lethality, complete penetrance 2.81052756596783e-74 1.398237464069e-70 1.3965786153905 0.635135135135135 12.2 12 2 absent mesoderm 3.11941198395017e-07 1.09289257888395e-05 1.39261669024045 0.633333333333333 12.2 12 2 abnormal blastocyst morphology 0.00413013832376115 0.0380508114087254 1.38875902627857 0.631578947368421 12.2 12 2 decreased circulating magnesium level 0.00413013832376115 0.0380508114087254 1.38875902627857 0.631578947368421 12.2 12 2 decreased bone marrow cell number 2.29202085154208e-08 1.00909767578954e-06 1.38558834357017 0.63013698630137 12.2 12 2 decreased platelet aggregation 1.58340393081896e-06 4.52726123897949e-05 1.38447273298758 0.62962962962963 12.2 12 2 abnormal eye muscle morphology 0.000678116776104758 0.00878549729458638 1.38447273298758 0.62962962962963 12.2 12 2 increased eosinophil cell number 2.84201859671084e-07 1.00993160847403e-05 1.38315919149519 0.629032258064516 12.2 12 2 spleen hypoplasia 2.56166197985595e-11 1.84699541301208e-09 1.38214588805819 0.628571428571429 12.2 12 2 abnormal humoral immune response 2.56166197985595e-11 1.84699541301208e-09 1.38214588805819 0.628571428571429 12.2 12 2 abnormal liver development 0.000115639079136721 0.0020257197841732 1.38214588805819 0.628571428571429 12.2 12 2 abnormal double-strand DNA break repair 2.01684475334495e-05 0.000436252289038745 1.38068484589323 0.627906976744186 12.2 12 2 decreased embryo size 4.03114719469675e-46 1.00274786468082e-42 1.38004296544418 0.627615062761506 12.2 12 2 abnormal extraembryonic tissue morphology 5.707363418351e-11 3.88960726113647e-09 1.37968216989766 0.627450980392157 12.2 12 2 impaired hematopoiesis 3.56997844792661e-06 9.25033478043483e-05 1.37968216989766 0.627450980392157 12.2 12 2 failure of primitive streak formation 0.000264347557340807 0.00426989966808608 1.3742927864215 0.625 12.2 12 2 abnormal embryonic hematopoiesis 0.000264347557340807 0.00426989966808608 1.3742927864215 0.625 12.2 12 2 abnormal spongiotrophoblast layer morphology 0.000264347557340807 0.00426989966808608 1.3742927864215 0.625 12.2 12 2 ocular hypertelorism 0.00157002823066444 0.0175132072815148 1.3742927864215 0.625 12.2 12 2 decreased liver cholesterol level 0.00979081596711856 0.0731556757740906 1.3742927864215 0.625 12.2 12 2 abnormal vagus ganglion morphology 0.0683219791623923 0.303483791368662 1.3742927864215 0.625 12.2 12 2 joint swelling 0.0683219791623923 0.303483791368662 1.3742927864215 0.625 12.2 12 2 decreased aerobic running capacity 0.0683219791623923 0.303483791368662 1.3742927864215 0.625 12.2 12 2 altered response to CNS ischemic injury 0.0683219791623923 0.303483791368662 1.3742927864215 0.625 12.2 12 2 liver cysts 0.0683219791623923 0.303483791368662 1.3742927864215 0.625 12.2 12 2 increased cardiac output 0.0683219791623923 0.303483791368662 1.3742927864215 0.625 12.2 12 2 abnormal platelet shape 0.0683219791623923 0.303483791368662 1.3742927864215 0.625 12.2 12 2 pulmonary interstitial fibrosis 0.0683219791623923 0.303483791368662 1.3742927864215 0.625 12.2 12 2 abnormal choroid pigmentation 0.0683219791623923 0.303483791368662 1.3742927864215 0.625 12.2 12 2 abnormal somite size 0.0683219791623923 0.303483791368662 1.3742927864215 0.625 12.2 12 2 abnormal vertebral body development 0.0683219791623923 0.303483791368662 1.3742927864215 0.625 12.2 12 2 choroidal neovascularization 0.0683219791623923 0.303483791368662 1.3742927864215 0.625 12.2 12 2 abnormal epidermal lamellar body morphology 0.0683219791623923 0.303483791368662 1.3742927864215 0.625 12.2 12 2 abnormal base-excision repair 0.0683219791623923 0.303483791368662 1.3742927864215 0.625 12.2 12 2 decreased hippocampus pyramidal cell number 0.0683219791623923 0.303483791368662 1.3742927864215 0.625 12.2 12 2 abnormal cerebellum deep nucleus morphology 0.0683219791623923 0.303483791368662 1.3742927864215 0.625 12.2 12 2 abnormal hepatic vein morphology 0.0683219791623923 0.303483791368662 1.3742927864215 0.625 12.2 12 2 myocardial trabeculae hypoplasia 0.0683219791623923 0.303483791368662 1.3742927864215 0.625 12.2 12 2 sinoatrial block 0.0683219791623923 0.303483791368662 1.3742927864215 0.625 12.2 12 2 increased susceptibility to parasitic infection induced morbidity/mortality 0.0683219791623923 0.303483791368662 1.3742927864215 0.625 12.2 12 2 decreased cranium length 0.0683219791623923 0.303483791368662 1.3742927864215 0.625 12.2 12 2 abnormal heart echocardiography feature 0.0683219791623923 0.303483791368662 1.3742927864215 0.625 12.2 12 2 increased testis apoptosis 0.0683219791623923 0.303483791368662 1.3742927864215 0.625 12.2 12 2 abnormal umbilical vein topology 0.0683219791623923 0.303483791368662 1.3742927864215 0.625 12.2 12 2 decreased basal metabolism 0.0683219791623923 0.303483791368662 1.3742927864215 0.625 12.2 12 2 decreased erythrocyte cell number 8.37064754671173e-16 1.06779414217669e-13 1.37254209497383 0.624203821656051 12.2 12 2 embryonic lethality, complete penetrance 1.62506614613172e-30 8.98300453000592e-28 1.37170790970723 0.623824451410658 12.2 12 2 pale liver 4.22099927672489e-08 1.76466146232826e-06 1.36686417676517 0.621621621621622 12.2 12 2 increased leukocyte cell number 2.01879924808381e-14 2.18337527374281e-12 1.36481490513583 0.620689655172414 12.2 12 2 increased neutrophil cell number 2.01879924808381e-14 2.18337527374281e-12 1.36481490513583 0.620689655172414 12.2 12 2 abnormal embryonic erythropoiesis 0.000605640698361136 0.00795003291384341 1.36481490513583 0.620689655172414 12.2 12 2 increased double-positive T cell number 0.000605640698361136 0.00795003291384341 1.36481490513583 0.620689655172414 12.2 12 2 lethality throughout fetal growth and development, incomplete penetrance 2.14196438790835e-17 3.94676771475705e-15 1.36354412775675 0.620111731843575 12.2 12 2 embryonic growth arrest 7.80044294238824e-22 2.28277668461068e-19 1.36349048504351 0.620087336244541 12.2 12 2 increased acute inflammation 0.00365212307699758 0.0342817213359679 1.36120428369368 0.619047619047619 12.2 12 2 absent segment of posterior cerebral artery 0.00365212307699758 0.0342817213359679 1.36120428369368 0.619047619047619 12.2 12 2 abnormal embryo turning 2.90100028099209e-06 7.55627036541134e-05 1.35930050147872 0.618181818181818 12.2 12 2 abnormal platelet physiology 2.90100028099209e-06 7.55627036541134e-05 1.35930050147872 0.618181818181818 12.2 12 2 decreased rib number 2.81652005263587e-09 1.40121872618635e-07 1.35885129443924 0.617977528089888 12.2 12 2 increased susceptibility to viral infection induced morbidity/mortality 0.000236080458447635 0.00388907377740724 1.35812463599301 0.617647058823529 12.2 12 2 abnormal T-helper 1 physiology 1.63014982091582e-05 0.000355701550835799 1.35674862319059 0.617021276595745 12.2 12 2 liver inflammation 6.41623403758965e-12 5.06678799000135e-10 1.35596888260255 0.616666666666667 12.2 12 2 seminiferous tubule degeneration 8.47552924840404e-08 3.29419984459454e-06 1.35546685784038 0.616438356164384 12.2 12 2 increased hepatocyte apoptosis 9.27467494516798e-05 0.00166575840621699 1.35314982047655 0.615384615384615 12.2 12 2 heart inflammation 0.00139110016255228 0.0157289166106763 1.35314982047655 0.615384615384615 12.2 12 2 abnormal grip strength 0.0234825765779249 0.144051564087763 1.35314982047655 0.615384615384615 12.2 12 2 abnormal tail bud morphology 0.0234825765779249 0.144051564087763 1.35314982047655 0.615384615384615 12.2 12 2 abnormal coping response 0.0234825765779249 0.144051564087763 1.35314982047655 0.615384615384615 12.2 12 2 axonal dystrophy 0.0234825765779249 0.144051564087763 1.35314982047655 0.615384615384615 12.2 12 2 abnormal exocrine pancreas morphology 0.0234825765779249 0.144051564087763 1.35314982047655 0.615384615384615 12.2 12 2 orthokeratosis 0.0234825765779249 0.144051564087763 1.35314982047655 0.615384615384615 12.2 12 2 absent hypoglossal nerve 0.0234825765779249 0.144051564087763 1.35314982047655 0.615384615384615 12.2 12 2 decreased macrophage cell number 3.66577343674726e-05 0.000753604249909819 1.3493056448502 0.613636363636364 12.2 12 2 osteopetrosis 0.000537363610398395 0.00720588668930463 1.34769357120044 0.612903225806452 12.2 12 2 preaxial polydactyly 0.000537363610398395 0.00720588668930463 1.34769357120044 0.612903225806452 12.2 12 2 decreased tumor growth/size 5.80464762930198e-06 0.00014511619073255 1.34375294672324 0.611111111111111 12.2 12 2 underdeveloped hair follicles 0.00854413926941337 0.0676864536072158 1.34375294672324 0.611111111111111 12.2 12 2 abnormal neutrophil morphology 0.00854413926941337 0.0676864536072158 1.34375294672324 0.611111111111111 12.2 12 2 decreased lactate dehydrogenase level 0.00854413926941337 0.0676864536072158 1.34375294672324 0.611111111111111 12.2 12 2 abnormal embryo size 6.20887533499055e-11 4.06436247257605e-09 1.34267189045074 0.610619469026549 12.2 12 2 increased spleen weight 6.20887533499055e-11 4.06436247257605e-09 1.34267189045074 0.610619469026549 12.2 12 2 increased inflammatory response 2.04284223847105e-09 1.04774640581376e-07 1.34246705873595 0.610526315789474 12.2 12 2 abnormal osteoclast physiology 9.31222216137177e-07 2.89551907830153e-05 1.33993546676096 0.609375 12.2 12 2 abnormal B cell morphology 0.003204472603056 0.0307172470138797 1.33844167025398 0.608695652173913 12.2 12 2 abnormal hematopoietic stem cell physiology 0.003204472603056 0.0307172470138797 1.33844167025398 0.608695652173913 12.2 12 2 abnormal spleen germinal center morphology 0.00122481060831706 0.0142038060055417 1.33502727823803 0.607142857142857 12.2 12 2 failure of blastocyst to hatch from the zona pellucida 0.00122481060831706 0.0142038060055417 1.33502727823803 0.607142857142857 12.2 12 2 decreased circulating serum albumin level 1.63219977176628e-09 8.54757248898655e-08 1.33264755046933 0.606060606060606 12.2 12 2 abnormal ovarian folliculogenesis 0.000474255804363848 0.0065357967498896 1.33264755046933 0.606060606060606 12.2 12 2 impaired macrophage phagocytosis 7.29781202079488e-05 0.00138076761166624 1.3295483701194 0.604651162790698 12.2 12 2 thymus atrophy 2.88910997082487e-05 0.000611630727866117 1.32848302687412 0.604166666666667 12.2 12 2 abnormal embryonic neuroepithelium morphology 4.58553971236236e-06 0.000116990051635912 1.32690337999317 0.603448275862069 12.2 12 2 abnormal neural tube closure 4.82026759881896e-08 1.99840260867703e-06 1.32461955317735 0.602409638554217 12.2 12 2 small gonad 0.00740574883233864 0.0602019615047136 1.31932107496464 0.6 12.2 12 2 increased mammary adenocarcinoma incidence 0.00740574883233864 0.0602019615047136 1.31932107496464 0.6 12.2 12 2 decreased myocardial infarction size 0.00740574883233864 0.0602019615047136 1.31932107496464 0.6 12.2 12 2 abnormal sperm mitochondrial sheath morphology 0.00740574883233864 0.0602019615047136 1.31932107496464 0.6 12.2 12 2 absent ductus venosus valve 0.00740574883233864 0.0602019615047136 1.31932107496464 0.6 12.2 12 2 increased cranium width 0.057246076475876 0.268425287905262 1.31932107496464 0.6 12.2 12 2 abnormal mammary gland physiology 0.057246076475876 0.268425287905262 1.31932107496464 0.6 12.2 12 2 abnormal gland morphology 0.057246076475876 0.268425287905262 1.31932107496464 0.6 12.2 12 2 increased natural killer cell mediated cytotoxicity 0.057246076475876 0.268425287905262 1.31932107496464 0.6 12.2 12 2 acrania 0.057246076475876 0.268425287905262 1.31932107496464 0.6 12.2 12 2 peritoneal inflammation 0.057246076475876 0.268425287905262 1.31932107496464 0.6 12.2 12 2 absent seminal vesicle 0.057246076475876 0.268425287905262 1.31932107496464 0.6 12.2 12 2 abnormal submandibular gland morphology 0.057246076475876 0.268425287905262 1.31932107496464 0.6 12.2 12 2 abnormal deltoid tuberosity morphology 0.057246076475876 0.268425287905262 1.31932107496464 0.6 12.2 12 2 abnormal corneal endothelium morphology 0.057246076475876 0.268425287905262 1.31932107496464 0.6 12.2 12 2 increased susceptibility to atherosclerosis 0.057246076475876 0.268425287905262 1.31932107496464 0.6 12.2 12 2 osteosclerosis 0.057246076475876 0.268425287905262 1.31932107496464 0.6 12.2 12 2 increased platelet aggregation 0.057246076475876 0.268425287905262 1.31932107496464 0.6 12.2 12 2 decreased transitional stage T2 B cell number 0.057246076475876 0.268425287905262 1.31932107496464 0.6 12.2 12 2 abnormal hippocampus neuron morphology 0.057246076475876 0.268425287905262 1.31932107496464 0.6 12.2 12 2 increased circulating fructosamine level 0.057246076475876 0.268425287905262 1.31932107496464 0.6 12.2 12 2 increased T-helper 17 cell number 0.057246076475876 0.268425287905262 1.31932107496464 0.6 12.2 12 2 abnormal inferior vena cava valve morphology 0.057246076475876 0.268425287905262 1.31932107496464 0.6 12.2 12 2 thin ventricle myocardium compact layer 0.057246076475876 0.268425287905262 1.31932107496464 0.6 12.2 12 2 decreased macrophage cytokine production 0.057246076475876 0.268425287905262 1.31932107496464 0.6 12.2 12 2 decreased macrophage apoptosis 0.057246076475876 0.268425287905262 1.31932107496464 0.6 12.2 12 2 abnormal cell migration 6.43801991442693e-05 0.00126597427171043 1.31932107496464 0.6 12.2 12 2 increased circulating serum albumin level 0.000416742527414009 0.00590325201561128 1.31932107496464 0.6 12.2 12 2 abnormal embryonic epiblast morphology 0.000416742527414009 0.00590325201561128 1.31932107496464 0.6 12.2 12 2 abnormal hippocampus pyramidal cell morphology 0.000416742527414009 0.00590325201561128 1.31932107496464 0.6 12.2 12 2 gastrointestinal hemorrhage 0.00107305811290553 0.0125610920275412 1.31932107496464 0.6 12.2 12 2 abnormal microglial cell physiology 0.00107305811290553 0.0125610920275412 1.31932107496464 0.6 12.2 12 2 abnormal brain vasculature morphology 0.00107305811290553 0.0125610920275412 1.31932107496464 0.6 12.2 12 2 absent egg cylinders 0.0201309791174126 0.127581682941564 1.31932107496464 0.6 12.2 12 2 bicuspid aortic valve 0.0201309791174126 0.127581682941564 1.31932107496464 0.6 12.2 12 2 abnormal coronary vessel morphology 0.0201309791174126 0.127581682941564 1.31932107496464 0.6 12.2 12 2 mandible hypoplasia 0.00279554329954932 0.0274316132450846 1.31932107496464 0.6 12.2 12 2 abnormal egg cylinder morphology 0.00279554329954932 0.0274316132450846 1.31932107496464 0.6 12.2 12 2 increased pre-B cell number 0.00279554329954932 0.0274316132450846 1.31932107496464 0.6 12.2 12 2 increased hepatocellular carcinoma incidence 8.96186773666411e-06 0.000210307981084453 1.31160574704087 0.596491228070175 12.2 12 2 kinked neural tube 2.24826991269065e-05 0.000484205316694199 1.31086388858666 0.596153846153846 12.2 12 2 anophthalmia 3.35274860145169e-08 1.43792450795019e-06 1.30943852009599 0.595505617977528 12.2 12 2 embryonic lethality during organogenesis, complete penetrance 1.03245390514193e-43 1.71215272602704e-40 1.3075414225096 0.594642857142857 12.2 12 2 abnormal angiogenesis 5.09895036757087e-07 1.71400527558548e-05 1.30743529951451 0.594594594594595 12.2 12 2 skin inflammation 0.000364888362779555 0.00552293232295834 1.30743529951451 0.594594594594595 12.2 12 2 bradykinesia 0.000936387072559484 0.0113934079920703 1.30557814710042 0.59375 12.2 12 2 abnormal fetal cardiomyocyte proliferation 0.00242816690647593 0.0241120366461432 1.3030331604589 0.592592592592593 12.2 12 2 decreased circulating fructosamine level 0.00242816690647593 0.0241120366461432 1.3030331604589 0.592592592592593 12.2 12 2 increased circulating alkaline phosphatase level 1.70102423645861e-13 1.62742222622723e-11 1.3030331604589 0.592592592592593 12.2 12 2 anemia 4.17165367224126e-17 7.41213464978581e-15 1.30264719092085 0.592417061611374 12.2 12 2 decreased leukocyte cell number 1.51138952533964e-11 1.12226311769623e-09 1.30006091328632 0.591240875912409 12.2 12 2 increased skin papilloma incidence 0.00638870591022073 0.0532392159185061 1.2993313617076 0.590909090909091 12.2 12 2 decreased susceptibility to viral infection induced morbidity/mortality 0.00638870591022073 0.0532392159185061 1.2993313617076 0.590909090909091 12.2 12 2 pale yolk sac 1.59587096508666e-07 5.83783680243098e-06 1.2981271621138 0.590361445783133 12.2 12 2 abnormal fertility/fecundity 9.80727770533388e-07 2.95180498073355e-05 1.29522388638081 0.589041095890411 12.2 12 2 abnormal brown adipose tissue morphology 0.000814506298529866 0.010310862176046 1.29345203427906 0.588235294117647 12.2 12 2 abnormal adipose tissue morphology 0.017176472532987 0.111396851617721 1.29345203427906 0.588235294117647 12.2 12 2 abnormal interatrial septum morphology 0.017176472532987 0.111396851617721 1.29345203427906 0.588235294117647 12.2 12 2 hyperlipidemia 0.017176472532987 0.111396851617721 1.29345203427906 0.588235294117647 12.2 12 2 abnormal dorsal-ventral axis patterning 0.017176472532987 0.111396851617721 1.29345203427906 0.588235294117647 12.2 12 2 abnormal circulating chemokine level 0.017176472532987 0.111396851617721 1.29345203427906 0.588235294117647 12.2 12 2 increased hepatoma incidence 0.017176472532987 0.111396851617721 1.29345203427906 0.588235294117647 12.2 12 2 abnormal spermatogenesis 1.33630631207958e-14 1.54607532618509e-12 1.29064018203063 0.58695652173913 12.2 12 2 abnormal cell death 0.000109538202362202 0.00194625913125698 1.29064018203063 0.58695652173913 12.2 12 2 dermatitis 1.51616657710914e-05 0.000332287608859822 1.28899185485051 0.586206896551724 12.2 12 2 lordosis 0.00210196798075461 0.0221552769157928 1.28899185485051 0.586206896551724 12.2 12 2 blood in lymph vessels 0.00210196798075461 0.0221552769157928 1.28899185485051 0.586206896551724 12.2 12 2 Leydig cell hyperplasia 0.000277353304988539 0.00443676106854656 1.28714251216062 0.585365853658537 12.2 12 2 abnormal cell differentiation 0.000277353304988539 0.00443676106854656 1.28714251216062 0.585365853658537 12.2 12 2 abnormal embryonic tissue morphology 8.01280994015311e-12 6.13288145419411e-10 1.28641283953468 0.585034013605442 12.2 12 2 abnormal cellular extravasation 0.00549269472440415 0.0471174391749268 1.28267326732673 0.583333333333333 12.2 12 2 abnormal inner cell mass apoptosis 0.00549269472440415 0.0471174391749268 1.28267326732673 0.583333333333333 12.2 12 2 increased growth rate 0.047850967146754 0.233619785628166 1.28267326732673 0.583333333333333 12.2 12 2 small intestinal inflammation 0.047850967146754 0.233619785628166 1.28267326732673 0.583333333333333 12.2 12 2 abnormal vascular endothelial cell development 0.047850967146754 0.233619785628166 1.28267326732673 0.583333333333333 12.2 12 2 increased osteosarcoma incidence 0.047850967146754 0.233619785628166 1.28267326732673 0.583333333333333 12.2 12 2 decreased left ventricle systolic pressure 0.047850967146754 0.233619785628166 1.28267326732673 0.583333333333333 12.2 12 2 abnormal rostral-caudal body axis extension 0.047850967146754 0.233619785628166 1.28267326732673 0.583333333333333 12.2 12 2 decreased red blood cell distribution width 0.047850967146754 0.233619785628166 1.28267326732673 0.583333333333333 12.2 12 2 increased grip strength 9.46646585213406e-08 3.62274366264361e-06 1.28065965152245 0.582417582417582 12.2 12 2 abnormal placenta labyrinth morphology 6.59886477118844e-07 2.1317761192638e-05 1.28035378583066 0.582278481012658 12.2 12 2 increased lung adenoma incidence 0.00181478896253079 0.0195415635345409 1.27676233061094 0.580645161290323 12.2 12 2 abnormal mitochondrial ATP synthesis coupled electron transport 0.00181478896253079 0.0195415635345409 1.27676233061094 0.580645161290323 12.2 12 2 increased neuron apoptosis 5.76756063130581e-07 1.87539961704225e-05 1.27588663628268 0.580246913580247 12.2 12 2 testicular atrophy 8.30250770019687e-05 0.00153550095942303 1.27534370579915 0.58 12.2 12 2 decreased brain weight 2.88226849928078e-05 0.000611630727866117 1.27302910742202 0.578947368421053 12.2 12 2 persistence of hyaloid vascular system 0.000611719706475157 0.00800869878872081 1.27302910742202 0.578947368421053 12.2 12 2 enlarged adrenal glands 0.0146133905696852 0.0966776836225847 1.27302910742202 0.578947368421053 12.2 12 2 abnormal digestive system development 0.0146133905696852 0.0966776836225847 1.27302910742202 0.578947368421053 12.2 12 2 increased liver adenoma incidence 0.0146133905696852 0.0966776836225847 1.27302910742202 0.578947368421053 12.2 12 2 Leydig cell hypoplasia 0.0146133905696852 0.0966776836225847 1.27302910742202 0.578947368421053 12.2 12 2 increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 0.0146133905696852 0.0966776836225847 1.27302910742202 0.578947368421053 12.2 12 2 decreased susceptibility to weight gain 0.0146133905696852 0.0966776836225847 1.27302910742202 0.578947368421053 12.2 12 2 liver hypoplasia 7.21011628084232e-05 0.00137434208801496 1.26857795669677 0.576923076923077 12.2 12 2 decreased IgA level 7.21011628084232e-05 0.00137434208801496 1.26857795669677 0.576923076923077 12.2 12 2 abnormal placenta vasculature 7.21011628084232e-05 0.00137434208801496 1.26857795669677 0.576923076923077 12.2 12 2 increased leukemia incidence 0.00471069303181801 0.0423014862522778 1.26857795669677 0.576923076923077 12.2 12 2 decreased brown adipose tissue amount 0.00156356522225356 0.0174803078218235 1.26601517294587 0.575757575757576 12.2 12 2 myeloid hyperplasia 0.00156356522225356 0.0174803078218235 1.26601517294587 0.575757575757576 12.2 12 2 abnormal female reproductive system morphology 0.000528600038325609 0.00712678913460679 1.26434936350778 0.575 12.2 12 2 hepatic necrosis 0.000180971503987121 0.00304763927087874 1.26317975262572 0.574468085106383 12.2 12 2 axon degeneration 6.25267240581458e-05 0.00123932451071424 1.26231337419456 0.574074074074074 12.2 12 2 abnormal embryo development 2.76815060131939e-10 1.60483628160503e-08 1.26111573342208 0.573529411764706 12.2 12 2 abnormal developmental patterning 9.42190709778654e-07 2.91142781437814e-05 1.26032704315728 0.573170731707317 12.2 12 2 increased carcinoma incidence 0.00134485799335101 0.0153455699929387 1.25649626187109 0.571428571428571 12.2 12 2 abnormal brainstem morphology 0.00403264197068777 0.0374998015031246 1.25649626187109 0.571428571428571 12.2 12 2 abnormal eye pigmentation 0.0124105831727933 0.0885834308244574 1.25649626187109 0.571428571428571 12.2 12 2 abnormal erythrocyte physiology 0.0124105831727933 0.0885834308244574 1.25649626187109 0.571428571428571 12.2 12 2 amyloid beta deposits 0.039983272724848 0.20256291426285 1.25649626187109 0.571428571428571 12.2 12 2 abnormal vascular endothelial cell migration 0.039983272724848 0.20256291426285 1.25649626187109 0.571428571428571 12.2 12 2 split sternum 0.039983272724848 0.20256291426285 1.25649626187109 0.571428571428571 12.2 12 2 spina bifida occulta 0.039983272724848 0.20256291426285 1.25649626187109 0.571428571428571 12.2 12 2 abnormal dendritic cell physiology 3.17313974795298e-08 1.37272784748401e-06 1.25356052294148 0.570093457943925 12.2 12 2 abnormal somite development 2.01552124536723e-06 5.63326864927077e-05 1.25252000787782 0.569620253164557 12.2 12 2 abnormal inflammatory response 5.72820327240799e-06 0.00014511619073255 1.25213342762848 0.569444444444444 12.2 12 2 thrombocytosis 4.68552303654734e-05 0.000943744012421984 1.25108032970785 0.568965517241379 12.2 12 2 prenatal lethality, complete penetrance 8.76462678826395e-19 1.74416073086453e-16 1.24971660578185 0.568345323741007 12.2 12 2 increased trabecular bone volume 0.00115517310803775 0.0134589841041869 1.24800642226385 0.567567567567568 12.2 12 2 oxidative stress 5.35536481170022e-07 1.77360746931724e-05 1.24602545968883 0.566666666666667 12.2 12 2 abnormal optic cup morphology 0.00344746550024958 0.0325448593239879 1.24602545968883 0.566666666666667 12.2 12 2 pallor 3.64147235596564e-12 2.92198789853694e-10 1.24393129925237 0.565714285714286 12.2 12 2 embryonic lethality during organogenesis, incomplete penetrance 1.82784679781088e-15 2.27338445477728e-13 1.24283869380727 0.565217391304348 12.2 12 2 abnormal vitelline vasculature morphology 1.80559971018021e-08 8.31746162791347e-07 1.24283869380727 0.565217391304348 12.2 12 2 abnormal allantois morphology 0.000338294927236858 0.00522676168634587 1.24283869380727 0.565217391304348 12.2 12 2 abnormal Wolffian duct morphology 0.0105282092095349 0.07805937528679 1.24283869380727 0.565217391304348 12.2 12 2 abnormal ulna morphology 0.0105282092095349 0.07805937528679 1.24283869380727 0.565217391304348 12.2 12 2 lethality throughout fetal growth and development, complete penetrance 7.42807715255542e-13 6.59905068463629e-11 1.23831013176506 0.563157894736842 12.2 12 2 decreased eosinophil cell number 3.0179092894391e-05 0.000630844483821828 1.23686350777935 0.5625 12.2 12 2 increased sacral vertebrae number 3.0179092894391e-05 0.000630844483821828 1.23686350777935 0.5625 12.2 12 2 abnormal bone marrow cell number 0.0334254745963621 0.18240786367654 1.23686350777935 0.5625 12.2 12 2 vasculature congestion 0.0334254745963621 0.18240786367654 1.23686350777935 0.5625 12.2 12 2 decreased mast cell number 0.0334254745963621 0.18240786367654 1.23686350777935 0.5625 12.2 12 2 abnormal hair follicle orientation 0.0334254745963621 0.18240786367654 1.23686350777935 0.5625 12.2 12 2 mixed cellular infiltration to dermis 0.0334254745963621 0.18240786367654 1.23686350777935 0.5625 12.2 12 2 reduced male mating frequency 0.0334254745963621 0.18240786367654 1.23686350777935 0.5625 12.2 12 2 impaired somite development 0.0334254745963621 0.18240786367654 1.23686350777935 0.5625 12.2 12 2 abnormal pulmonary alveolus wall morphology 0.0334254745963621 0.18240786367654 1.23686350777935 0.5625 12.2 12 2 embryonic lethality between somite formation and embryo turning, incomplete penetrance 0.0334254745963621 0.18240786367654 1.23686350777935 0.5625 12.2 12 2 scaly skin 0.000849637530922975 0.0106472209479642 1.23351157415393 0.560975609756098 12.2 12 2 hemopericardium 0.000849637530922975 0.0106472209479642 1.23351157415393 0.560975609756098 12.2 12 2 abnormal vascular development 2.60233626667402e-05 0.000558044091668244 1.23269898418413 0.560606060606061 12.2 12 2 small spleen 8.48976341284691e-07 2.67320082145022e-05 1.23233287221972 0.56043956043956 12.2 12 2 decreased hemoglobin content 9.76444408570672e-10 5.39756770293233e-08 1.2319901291041 0.560283687943262 12.2 12 2 ruffled hair 0.00892543290149214 0.0698176551649739 1.23136633663366 0.56 12.2 12 2 abnormal thyroid gland morphology 0.00892543290149214 0.0698176551649739 1.23136633663366 0.56 12.2 12 2 increased cellular sensitivity to ionizing radiation 0.00892543290149214 0.0698176551649739 1.23136633663366 0.56 12.2 12 2 abnormal preimplantation embryo development 0.00892543290149214 0.0698176551649739 1.23136633663366 0.56 12.2 12 2 increased bone mineral content 8.01128917672838e-08 3.16318759160505e-06 1.23055941242879 0.559633027522936 12.2 12 2 lung inflammation 2.36188162110698e-09 1.19901643520482e-07 1.22877943256511 0.558823529411765 12.2 12 2 abnormal hepatocyte morphology 6.9268495839078e-08 2.77911908709204e-06 1.22819679651363 0.558558558558559 12.2 12 2 abnormal placenta morphology 5.85841491355303e-06 0.000145728070974632 1.22468622992498 0.556962025316456 12.2 12 2 abnormal immune system physiology 1.59622150596882e-08 7.42168410485502e-07 1.22356390016882 0.556451612903226 12.2 12 2 rectal prolapse 0.00756385068849562 0.0611872474394564 1.22159358793022 0.555555555555556 12.2 12 2 decreased bone ossification 0.00756385068849562 0.0611872474394564 1.22159358793022 0.555555555555556 12.2 12 2 increased susceptibility to parasitic infection 1.5402663937347e-06 4.42937879123129e-05 1.22159358793022 0.555555555555556 12.2 12 2 gliosis 5.51101621511719e-05 0.00110109661326137 1.22159358793022 0.555555555555556 12.2 12 2 small placenta 0.000623030022688118 0.00813536578181991 1.22159358793022 0.555555555555556 12.2 12 2 cortical renal glomerulopathies 0.0279668891124539 0.168240959291969 1.22159358793022 0.555555555555556 12.2 12 2 primary atelectasis 0.0279668891124539 0.168240959291969 1.22159358793022 0.555555555555556 12.2 12 2 abnormal aerobic respiration 0.0279668891124539 0.168240959291969 1.22159358793022 0.555555555555556 12.2 12 2 distorted hair follicle pattern 0.114973648264877 0.393503770042863 1.22159358793022 0.555555555555556 12.2 12 2 psoriasis 0.114973648264877 0.393503770042863 1.22159358793022 0.555555555555556 12.2 12 2 abnormal vomeronasal organ morphology 0.114973648264877 0.393503770042863 1.22159358793022 0.555555555555556 12.2 12 2 abnormal posterior semicircular canal morphology 0.114973648264877 0.393503770042863 1.22159358793022 0.555555555555556 12.2 12 2 genetic imprinting 0.114973648264877 0.393503770042863 1.22159358793022 0.555555555555556 12.2 12 2 decreased susceptibility to induced choroidal neovascularization 0.114973648264877 0.393503770042863 1.22159358793022 0.555555555555556 12.2 12 2 decreased fear-related response 0.114973648264877 0.393503770042863 1.22159358793022 0.555555555555556 12.2 12 2 short frontal bone 0.114973648264877 0.393503770042863 1.22159358793022 0.555555555555556 12.2 12 2 decreased susceptibility to atherosclerosis 0.114973648264877 0.393503770042863 1.22159358793022 0.555555555555556 12.2 12 2 abnormal optic chiasm morphology 0.114973648264877 0.393503770042863 1.22159358793022 0.555555555555556 12.2 12 2 multiflagellated sperm 0.114973648264877 0.393503770042863 1.22159358793022 0.555555555555556 12.2 12 2 decreased transitional stage T1 B cell number 0.114973648264877 0.393503770042863 1.22159358793022 0.555555555555556 12.2 12 2 abnormal cerebellar layer morphology 0.114973648264877 0.393503770042863 1.22159358793022 0.555555555555556 12.2 12 2 shortened ST segment 0.114973648264877 0.393503770042863 1.22159358793022 0.555555555555556 12.2 12 2 iris coloboma 0.114973648264877 0.393503770042863 1.22159358793022 0.555555555555556 12.2 12 2 fusion of atlas and occipital bones 0.114973648264877 0.393503770042863 1.22159358793022 0.555555555555556 12.2 12 2 decreased effector memory CD4-positive, alpha-beta T cell number 0.114973648264877 0.393503770042863 1.22159358793022 0.555555555555556 12.2 12 2 abnormal pulmonary alveolar system morphology 0.114973648264877 0.393503770042863 1.22159358793022 0.555555555555556 12.2 12 2 abnormal oxidative phosphorylation 0.114973648264877 0.393503770042863 1.22159358793022 0.555555555555556 12.2 12 2 abnormal lung lobe morphology 0.114973648264877 0.393503770042863 1.22159358793022 0.555555555555556 12.2 12 2 increased core body temperature 0.114973648264877 0.393503770042863 1.22159358793022 0.555555555555556 12.2 12 2 decreased bone trabecular spacing 0.114973648264877 0.393503770042863 1.22159358793022 0.555555555555556 12.2 12 2 abnormal ductus venosus valve topology 0.114973648264877 0.393503770042863 1.22159358793022 0.555555555555556 12.2 12 2 abnormal infrahyoid muscle connection 0.114973648264877 0.393503770042863 1.22159358793022 0.555555555555556 12.2 12 2 symmetric azygos veins 0.114973648264877 0.393503770042863 1.22159358793022 0.555555555555556 12.2 12 2 increased cardiac muscle glycogen level 0.114973648264877 0.393503770042863 1.22159358793022 0.555555555555556 12.2 12 2 abnormal seminiferous tubule morphology 1.14112965798659e-09 6.17078266139485e-08 1.21992017205634 0.554794520547945 12.2 12 2 decreased birth body size 9.30732927188296e-08 3.58945450601688e-06 1.21516414799375 0.552631578947368 12.2 12 2 increased bone marrow cell number 0.00182649789820332 0.0195415635345409 1.21516414799375 0.552631578947368 12.2 12 2 decreased hair follicle number 0.00182649789820332 0.0195415635345409 1.21516414799375 0.552631578947368 12.2 12 2 rib fusion 4.06725121224417e-05 0.000825901011465907 1.21430049188288 0.552238805970149 12.2 12 2 increased rib number 1.05768217068121e-05 0.000244742734843675 1.21219671417691 0.551282051282051 12.2 12 2 decreased circulating creatinine level 0.000455915302077599 0.00633569449116216 1.21162139537569 0.551020408163265 12.2 12 2 microcephaly 3.49193974253276e-05 0.000720846482120351 1.2109710349917 0.550724637681159 12.2 12 2 abnormal cell proliferation 0.0234227304708865 0.144051564087763 1.20937765205092 0.55 12.2 12 2 abnormal vascular regression 0.0234227304708865 0.144051564087763 1.20937765205092 0.55 12.2 12 2 increased urine glucose level 0.0234227304708865 0.144051564087763 1.20937765205092 0.55 12.2 12 2 brain inflammation 0.0234227304708865 0.144051564087763 1.20937765205092 0.55 12.2 12 2 anencephaly 0.0234227304708865 0.144051564087763 1.20937765205092 0.55 12.2 12 2 abnormal hair texture 0.0234227304708865 0.144051564087763 1.20937765205092 0.55 12.2 12 2 dilated vasculature 0.0234227304708865 0.144051564087763 1.20937765205092 0.55 12.2 12 2 abnormal induced retinal neovascularization 0.0234227304708865 0.144051564087763 1.20937765205092 0.55 12.2 12 2 abnormal gastrulation 0.000389784138121774 0.00575423171262856 1.20722189866045 0.549019607843137 12.2 12 2 failure of chorioallantoic fusion 0.000389784138121774 0.00575423171262856 1.20722189866045 0.549019607843137 12.2 12 2 abnormal capillary morphology 0.00543000129605097 0.0470631645432989 1.20583109002144 0.548387096774194 12.2 12 2 decreased thymus weight 0.00543000129605097 0.0470631645432989 1.20583109002144 0.548387096774194 12.2 12 2 disheveled coat 0.0013260451677529 0.0151656889875188 1.20414225095979 0.547619047619048 12.2 12 2 abnormal reproductive system morphology 0.0013260451677529 0.0151656889875188 1.20414225095979 0.547619047619048 12.2 12 2 abnormal mesoderm development 0.000333146263802203 0.00516324816952012 1.20315443943316 0.547169811320755 12.2 12 2 decreased neutrophil cell number 1.23189099341666e-07 4.60801330244201e-06 1.2027998404236 0.547008547008547 12.2 12 2 decreased caudal vertebrae number 8.51993836679758e-05 0.00156987753240067 1.20250618811881 0.546875 12.2 12 2 increased oxygen consumption 5.75868582063044e-06 0.00014511619073255 1.20170718068485 0.546511627906977 12.2 12 2 increased osteoblast cell number 0.00460087993963949 0.0417218882863492 1.1993827954224 0.545454545454545 12.2 12 2 abnormal chorion morphology 0.0196368358878804 0.125408547550969 1.1993827954224 0.545454545454545 12.2 12 2 abnormal sperm midpiece morphology 0.0196368358878804 0.125408547550969 1.1993827954224 0.545454545454545 12.2 12 2 embryonic lethality before implantation, incomplete penetrance 0.0196368358878804 0.125408547550969 1.1993827954224 0.545454545454545 12.2 12 2 abnormal ear position 0.0933321920012287 0.348996485632201 1.1993827954224 0.545454545454545 12.2 12 2 abnormal food preference 0.0933321920012287 0.348996485632201 1.1993827954224 0.545454545454545 12.2 12 2 impaired myelopoiesis 0.0933321920012287 0.348996485632201 1.1993827954224 0.545454545454545 12.2 12 2 failure of somite differentiation 0.0933321920012287 0.348996485632201 1.1993827954224 0.545454545454545 12.2 12 2 pulmonary hypertension 0.0933321920012287 0.348996485632201 1.1993827954224 0.545454545454545 12.2 12 2 abnormal radial glial cell morphology 0.0933321920012287 0.348996485632201 1.1993827954224 0.545454545454545 12.2 12 2 abnormal coronal suture morphology 0.0933321920012287 0.348996485632201 1.1993827954224 0.545454545454545 12.2 12 2 abnormal platelet aggregation 0.0933321920012287 0.348996485632201 1.1993827954224 0.545454545454545 12.2 12 2 increased number of Howell-Jolly bodies 0.0933321920012287 0.348996485632201 1.1993827954224 0.545454545454545 12.2 12 2 aberrant origin of the right subclavian artery 0.0933321920012287 0.348996485632201 1.1993827954224 0.545454545454545 12.2 12 2 decreased embryonic cilium length 0.0933321920012287 0.348996485632201 1.1993827954224 0.545454545454545 12.2 12 2 chylous ascites 0.0933321920012287 0.348996485632201 1.1993827954224 0.545454545454545 12.2 12 2 decreased circulating calcium level 0.000284667490766488 0.00451427942001003 1.1993827954224 0.545454545454545 12.2 12 2 abnormal head morphology 0.000284667490766488 0.00451427942001003 1.1993827954224 0.545454545454545 12.2 12 2 decreased circulating alanine transaminase level 6.24510081995342e-05 0.00123932451071424 1.19644313170813 0.544117647058823 12.2 12 2 decreased susceptibility to induced arthritis 0.000243192869864806 0.00397988331439937 1.19587582818432 0.543859649122807 12.2 12 2 increased macrophage cell number 0.000243192869864806 0.00397988331439937 1.19587582818432 0.543859649122807 12.2 12 2 abnormal craniofacial morphology 9.58940514418595e-07 2.92682764370093e-05 1.19550129770259 0.543689320388349 12.2 12 2 abnormal intestinal goblet cell morphology 0.00389879749105973 0.0363912148555763 1.19367144877753 0.542857142857143 12.2 12 2 decreased glycogen level 0.00389879749105973 0.0363912148555763 1.19367144877753 0.542857142857143 12.2 12 2 increased red blood cell distribution width 0.00389879749105973 0.0363912148555763 1.19367144877753 0.542857142857143 12.2 12 2 abnormal startle reflex 0.0164792717828711 0.10801630714069 1.19105374823197 0.541666666666667 12.2 12 2 abnormal primitive streak formation 0.0164792717828711 0.10801630714069 1.19105374823197 0.541666666666667 12.2 12 2 small seminiferous tubules 3.91335882872949e-05 0.000801191776663753 1.18857754501319 0.540540540540541 12.2 12 2 abnormal branching of the mammary ductal tree 0.00330436377070573 0.0314927390024157 1.18857754501319 0.540540540540541 12.2 12 2 abnormal respiratory electron transport chain 0.00330436377070573 0.0314927390024157 1.18857754501319 0.540540540540541 12.2 12 2 abnormal interventricular septum morphology 0.000697653698619876 0.00899178018298934 1.18738896746818 0.54 12.2 12 2 abnormal muscle physiology 7.48619798727206e-06 0.000179921908148205 1.18590658423788 0.539325842696629 12.2 12 2 kinked tail 1.6882134199299e-06 4.7720805478132e-05 1.1856643647558 0.53921568627451 12.2 12 2 abnormal Mullerian duct morphology 0.013842629416112 0.0939658331171059 1.18400609291698 0.538461538461538 12.2 12 2 pulmonary edema 0.013842629416112 0.0939658331171059 1.18400609291698 0.538461538461538 12.2 12 2 short premaxilla 0.0762807561437214 0.328853346460151 1.18400609291698 0.538461538461538 12.2 12 2 absent common myeloid progenitor cells 0.0762807561437214 0.328853346460151 1.18400609291698 0.538461538461538 12.2 12 2 uterus hypoplasia 0.0762807561437214 0.328853346460151 1.18400609291698 0.538461538461538 12.2 12 2 excessive scratching 0.0762807561437214 0.328853346460151 1.18400609291698 0.538461538461538 12.2 12 2 increased pituitary adenoma incidence 0.0762807561437214 0.328853346460151 1.18400609291698 0.538461538461538 12.2 12 2 abnormal bile duct development 0.0762807561437214 0.328853346460151 1.18400609291698 0.538461538461538 12.2 12 2 tracheoesophageal fistula 0.0762807561437214 0.328853346460151 1.18400609291698 0.538461538461538 12.2 12 2 empty decidua capsularis 0.0762807561437214 0.328853346460151 1.18400609291698 0.538461538461538 12.2 12 2 abnormal axon morphology 1.06284515050481e-06 3.12878971820202e-05 1.18087380166588 0.537037037037037 12.2 12 2 increased cell proliferation 0.000505894300192624 0.00685783145356486 1.18087380166588 0.537037037037037 12.2 12 2 neurodegeneration 0.000505894300192624 0.00685783145356486 1.18087380166588 0.537037037037037 12.2 12 2 liver fibrosis 0.00237492525261894 0.0236778619875335 1.17988063614724 0.536585365853659 12.2 12 2 increased tumor growth/size 0.00237492525261894 0.0236778619875335 1.17988063614724 0.536585365853659 12.2 12 2 increased bone trabecula number 0.00237492525261894 0.0236778619875335 1.17988063614724 0.536585365853659 12.2 12 2 abnormal sternum morphology 9.42844331572123e-05 0.00168123675611875 1.17910337617613 0.536231884057971 12.2 12 2 decreased spleen weight 9.42844331572123e-05 0.00168123675611875 1.17910337617613 0.536231884057971 12.2 12 2 small superior cervical ganglion 0.0116383222859662 0.0850229858629689 1.17796524550414 0.535714285714286 12.2 12 2 straub tail 0.0116383222859662 0.0850229858629689 1.17796524550414 0.535714285714286 12.2 12 2 preweaning lethality, incomplete penetrance 5.1270184274011e-21 1.34246929875371e-18 1.1773892233792 0.535452322738386 12.2 12 2 abnormal vasculogenesis 0.00201403955031852 0.0214099289804158 1.17613894279793 0.534883720930233 12.2 12 2 abnormal spermiogenesis 0.000366862639891284 0.00552293232295834 1.17525727942252 0.53448275862069 12.2 12 2 astrocytosis 6.87099537934559e-05 0.00133008568141028 1.17473794346167 0.534246575342466 12.2 12 2 increased erythrocyte cell number 0.000312427057066989 0.00487249093701653 1.17272984441301 0.533333333333333 12.2 12 2 trabecula carnea hypoplasia 0.00170836945621828 0.0187205683803655 1.17272984441301 0.533333333333333 12.2 12 2 abnormal ectoderm development 0.00170836945621828 0.0187205683803655 1.17272984441301 0.533333333333333 12.2 12 2 disorganized myocardium 0.00979330252573756 0.0731556757740906 1.17272984441301 0.533333333333333 12.2 12 2 abnormal fat pad morphology 0.00979330252573756 0.0731556757740906 1.17272984441301 0.533333333333333 12.2 12 2 increased airway responsiveness 0.0626716082762028 0.288428539476511 1.17272984441301 0.533333333333333 12.2 12 2 arthritis 0.0626716082762028 0.288428539476511 1.17272984441301 0.533333333333333 12.2 12 2 liver vascular congestion 0.0626716082762028 0.288428539476511 1.17272984441301 0.533333333333333 12.2 12 2 abnormal microglial cell activation 0.0626716082762028 0.288428539476511 1.17272984441301 0.533333333333333 12.2 12 2 decreased trabecular bone mass 0.0626716082762028 0.288428539476511 1.17272984441301 0.533333333333333 12.2 12 2 pericardial effusion 0.000266081520457675 0.00428399858989298 1.1703654697267 0.532258064516129 12.2 12 2 decreased bone trabecula number 0.00144941408579379 0.0163510999474469 1.16961088206085 0.531914893617021 12.2 12 2 increased circulating follicle stimulating hormone level 0.00824728490103464 0.0660233880759872 1.16814886845827 0.53125 12.2 12 2 decreased susceptibility to parasitic infection 0.00824728490103464 0.0660233880759872 1.16814886845827 0.53125 12.2 12 2 abnormal liver morphology 1.08247160765768e-09 5.9179079649417e-08 1.16699722645848 0.53072625698324 12.2 12 2 abnormal testis morphology 9.90857149311563e-07 2.95180498073355e-05 1.1663563126499 0.530434782608696 12.2 12 2 abnormal nervous system physiology 9.90857149311563e-07 2.95180498073355e-05 1.1663563126499 0.530434782608696 12.2 12 2 pericardial edema 0.00016442398912177 0.00279727362206213 1.16410683085115 0.529411764705882 12.2 12 2 decreased mean corpuscular hemoglobin 0.00016442398912177 0.00279727362206213 1.16410683085115 0.529411764705882 12.2 12 2 enlarged liver sinusoidal spaces 0.0069504500303924 0.0572491538099374 1.16410683085115 0.529411764705882 12.2 12 2 abnormal oocyte morphology 0.0069504500303924 0.0572491538099374 1.16410683085115 0.529411764705882 12.2 12 2 abnormal glutamate-mediated receptor currents 0.0517056019176592 0.248057251244315 1.16410683085115 0.529411764705882 12.2 12 2 absence seizures 0.0517056019176592 0.248057251244315 1.16410683085115 0.529411764705882 12.2 12 2 abnormal melanosome morphology 0.0517056019176592 0.248057251244315 1.16410683085115 0.529411764705882 12.2 12 2 enhanced behavioral response to cocaine 0.0517056019176592 0.248057251244315 1.16410683085115 0.529411764705882 12.2 12 2 increased circulating magnesium level 0.0517056019176592 0.248057251244315 1.16410683085115 0.529411764705882 12.2 12 2 abnormal cell cytoskeleton morphology 0.0517056019176592 0.248057251244315 1.16410683085115 0.529411764705882 12.2 12 2 abnormal bone structure 3.67364353513559e-10 2.0768609758295e-08 1.16209628364761 0.528497409326425 12.2 12 2 atrioventricular septal defect 0.000886341757853434 0.0110515043742377 1.16166635531478 0.528301886792453 12.2 12 2 azoospermia 1.28223075135816e-08 6.01801696981779e-07 1.16166635531478 0.528301886792453 12.2 12 2 increased susceptibility to bacterial infection induced morbidity/mortality 0.000119328112938706 0.00208300828726338 1.16051390853371 0.527777777777778 12.2 12 2 abnormal pharyngeal arch morphology 0.00586156276486371 0.049425889415588 1.16051390853371 0.527777777777778 12.2 12 2 kyphosis 4.08417331447897e-08 1.72192900335024e-06 1.15807072135785 0.526666666666667 12.2 12 2 incomplete embryo turning 0.000639251886553858 0.00830359826528836 1.15729918856547 0.526315789473684 12.2 12 2 absent vitelline blood vessels 0.000639251886553858 0.00830359826528836 1.15729918856547 0.526315789473684 12.2 12 2 decreased neuron apoptosis 0.00494643696237508 0.0437096339037585 1.15729918856547 0.526315789473684 12.2 12 2 small superior vagus ganglion 0.0428041097155304 0.213496980734706 1.15729918856547 0.526315789473684 12.2 12 2 thin dermal layer 0.0428041097155304 0.213496980734706 1.15729918856547 0.526315789473684 12.2 12 2 increased malignant tumor incidence 0.0428041097155304 0.213496980734706 1.15729918856547 0.526315789473684 12.2 12 2 abnormal metatarsal bone morphology 0.0428041097155304 0.213496980734706 1.15729918856547 0.526315789473684 12.2 12 2 increased susceptibility to ischemic brain injury 0.0428041097155304 0.213496980734706 1.15729918856547 0.526315789473684 12.2 12 2 abnormal sternebra morphology 0.0428041097155304 0.213496980734706 1.15729918856547 0.526315789473684 12.2 12 2 decreased eye pigmentation 0.0428041097155304 0.213496980734706 1.15729918856547 0.526315789473684 12.2 12 2 shortened RR interval 0.0428041097155304 0.213496980734706 1.15729918856547 0.526315789473684 12.2 12 2 reduced fertility 1.52062883952381e-07 5.60379887157849e-06 1.1548014205326 0.525179856115108 12.2 12 2 increased osteoclast cell number 0.000461417382628838 0.00639429381219629 1.15350476499641 0.524590163934426 12.2 12 2 sparse hair 5.36085092018544e-05 0.00107541263419042 1.15306516714389 0.524390243902439 12.2 12 2 abnormal salivary gland morphology 0.0355360924987889 0.183415914378399 1.15178824004849 0.523809523809524 12.2 12 2 trunk curl 0.0355360924987889 0.183415914378399 1.15178824004849 0.523809523809524 12.2 12 2 edema 7.35427837118286e-09 3.51803220159949e-07 1.15057070491102 0.523255813953488 12.2 12 2 teratozoospermia 3.31975338692024e-05 0.000691036531377749 1.1494085122798 0.522727272727273 12.2 12 2 osteoporosis 0.00298279713201419 0.0287660296650151 1.1494085122798 0.522727272727273 12.2 12 2 ventricular septal defect 3.02379054247418e-07 1.06690481906447e-05 1.14793868042266 0.522058823529412 12.2 12 2 pancreas inflammation 0.0295735195369845 0.171746328847455 1.14723571736056 0.521739130434783 12.2 12 2 abnormal cardiovascular development 0.0295735195369845 0.171746328847455 1.14723571736056 0.521739130434783 12.2 12 2 dilated heart 0.0295735195369845 0.171746328847455 1.14723571736056 0.521739130434783 12.2 12 2 decreased effector memory CD8-positive, alpha-beta T cell number 0.0295735195369845 0.171746328847455 1.14723571736056 0.521739130434783 12.2 12 2 decreased circulating alkaline phosphatase level 0.00180667819799142 0.0195415635345409 1.14341159830269 0.52 12.2 12 2 spontaneous skin ulceration 0.0246625972376985 0.150342070288552 1.14341159830269 0.52 12.2 12 2 abnormal primitive streak morphology 0.0246625972376985 0.150342070288552 1.14341159830269 0.52 12.2 12 2 absent corpus luteum 0.00152991992734729 0.0171813806739341 1.14172016102709 0.519230769230769 12.2 12 2 hemorrhage 3.45513734134824e-11 2.42102933425458e-09 1.14154022089139 0.519148936170213 12.2 12 2 abnormal cell adhesion 0.00129605440456508 0.0149602567580308 1.14015401540154 0.518518518518518 12.2 12 2 abnormal atrioventricular cushion morphology 0.0206043911227758 0.129863828233688 1.14015401540154 0.518518518518518 12.2 12 2 decreased heart weight 9.13592080745631e-05 0.00164678282670635 1.14015401540154 0.518518518518518 12.2 12 2 abnormal microglial cell morphology 0.0172413217579187 0.111396851617721 1.13734575427986 0.517241379310345 12.2 12 2 decreased trophoblast giant cell number 0.0172413217579187 0.111396851617721 1.13734575427986 0.517241379310345 12.2 12 2 polychromatophilia 0.0172413217579187 0.111396851617721 1.13734575427986 0.517241379310345 12.2 12 2 epidermal hyperplasia 0.000789579353721662 0.0101241167133125 1.13608203677511 0.516666666666667 12.2 12 2 pale kidney 0.0144474905040698 0.0964782083996609 1.13489984943195 0.516129032258065 12.2 12 2 alopecia 2.96510724073877e-05 0.000625059683164211 1.13415320479416 0.515789473684211 12.2 12 2 enlarged pericardium 0.012121590172517 0.0879080336855278 1.13275041789893 0.515151515151515 12.2 12 2 increased cardiomyocyte apoptosis 0.012121590172517 0.0879080336855278 1.13275041789893 0.515151515151515 12.2 12 2 small testis 2.16503473577268e-12 1.79517463507818e-10 1.13130188795277 0.514492753623188 12.2 12 2 abnormal midbrain development 0.010181611542627 0.0757152726824654 1.13084663568398 0.514285714285714 12.2 12 2 double outlet right ventricle 1.13488385729469e-05 0.000260186506453505 1.13025948789806 0.514018691588785 12.2 12 2 reduced female fertility 1.61251864421049e-10 9.90404969746568e-09 1.1278678729942 0.512931034482759 12.2 12 2 failure of heart looping 0.0072047116149801 0.0591475912285908 1.12762485039713 0.512820512820513 12.2 12 2 arrested B cell differentiation 0.00606853110173718 0.0509122128687057 1.12624969814055 0.51219512195122 12.2 12 2 arrest of spermatogenesis 0.000111401317500656 0.00196532466158072 1.12561123459285 0.511904761904762 12.2 12 2 decreased inflammatory response 0.000111401317500656 0.00196532466158072 1.12561123459285 0.511904761904762 12.2 12 2 abnormal homeostasis 0.00511547351284622 0.0447266796597714 1.12500246702411 0.511627906976744 12.2 12 2 cleft palate 1.67705828231178e-06 4.76763711685778e-05 1.12461211224721 0.511450381679389 12.2 12 2 abnormal myocardial trabeculae morphology 0.00431515333852806 0.039463029152899 1.1238661008958 0.511111111111111 12.2 12 2 increased respiratory quotient 0.00364242629388091 0.0342817213359679 1.12282644677842 0.51063829787234 12.2 12 2 abnormal trophoblast layer morphology 0.00259985629155504 0.0256632639890602 1.12099176304185 0.509803921568627 12.2 12 2 abnormal thrombosis 0.00259985629155504 0.0256632639890602 1.12099176304185 0.509803921568627 12.2 12 2 increased circulating bilirubin level 0.00219825110336015 0.0226252061018711 1.12017827119639 0.509433962264151 12.2 12 2 increased sensitivity to xenobiotic induced morbidity/mortality 1.37346034792648e-05 0.00031058932867883 1.11942394239424 0.509090909090909 12.2 12 2 decreased total body fat amount 5.35228614424978e-14 5.32552471352853e-12 1.11918454463068 0.508982035928144 12.2 12 2 increased circulating aspartate transaminase level 0.000956377452025752 0.0114650068044051 1.11688556610763 0.507936507936508 12.2 12 2 abnormal ovary morphology 0.000494668514065015 0.0067423996095163 1.11491921827998 0.507042253521127 12.2 12 2 abnormal skeletal muscle fiber morphology 0.000494668514065015 0.0067423996095163 1.11491921827998 0.507042253521127 12.2 12 2 delayed bone ossification 0.000356385891572805 0.00545544557099909 1.11409335219236 0.506666666666667 12.2 12 2 abnormal neurocranium morphology 0.000356385891572805 0.00545544557099909 1.11409335219236 0.506666666666667 12.2 12 2 abnormal neural tube morphology 2.18635631879749e-07 7.88197296088225e-06 1.11300749122531 0.506172839506173 12.2 12 2 abnormal lung development 0.000157678913347037 0.00270500894448796 1.11236874947999 0.505882352941176 12.2 12 2 hydroencephaly 1.40181201290911e-05 0.000314144809199227 1.10899452678187 0.504347826086956 12.2 12 2 premature death 2.22917443064897e-32 1.38626784905983e-29 1.10837271880498 0.504065040650406 12.2 12 2 reduced male fertility 1.93873765250573e-09 1.00471039804334e-07 1.10427755173252 0.502202643171806 12.2 12 2 perinatal lethality, incomplete penetrance 3.14827680563525e-09 1.55076010970647e-07 1.0994342291372 0.5 12.2 12 2 abnormal heart development 6.83988788444363e-07 2.19538336936175e-05 1.0994342291372 0.5 12.2 12 2 decreased hematocrit 1.77655092638957e-06 4.99341291456956e-05 1.0994342291372 0.5 12.2 12 2 abnormal coat/hair pigmentation 2.69446777994103e-05 0.000575320910094705 1.0994342291372 0.5 12.2 12 2 abnormal forebrain development 0.00069396807738276 0.00896750957137462 1.0994342291372 0.5 12.2 12 2 abnormal small intestine morphology 0.00310044780215523 0.0298350634733506 1.0994342291372 0.5 12.2 12 2 abnormal osteoclast morphology 0.00515048227285184 0.0449537707148033 1.0994342291372 0.5 12.2 12 2 abnormal myelin sheath morphology 0.0061077164043261 0.0510687211958359 1.0994342291372 0.5 12.2 12 2 atrial septal defect 0.0061077164043261 0.0510687211958359 1.0994342291372 0.5 12.2 12 2 decreased blood urea nitrogen level 0.00724814989367825 0.0594061708748753 1.0994342291372 0.5 12.2 12 2 skin edema 0.00860836885750282 0.0679787858191691 1.0994342291372 0.5 12.2 12 2 abnormal pancreas morphology 0.00860836885750282 0.0679787858191691 1.0994342291372 0.5 12.2 12 2 abnormal uterus morphology 0.0145016603203903 0.0966776836225847 1.0994342291372 0.5 12.2 12 2 abnormal lumbar vertebrae morphology 0.020647696107105 0.129863828233688 1.0994342291372 0.5 12.2 12 2 abnormal depression-related behavior 0.020647696107105 0.129863828233688 1.0994342291372 0.5 12.2 12 2 abnormal cellular respiration 0.0246893409900998 0.150342070288552 1.0994342291372 0.5 12.2 12 2 rib bifurcation 0.0295704599595854 0.171746328847455 1.0994342291372 0.5 12.2 12 2 increased bone resorption 0.0295704599595854 0.171746328847455 1.0994342291372 0.5 12.2 12 2 corneal vascularization 0.0295704599595854 0.171746328847455 1.0994342291372 0.5 12.2 12 2 abnormal renal tubule epithelium morphology 0.0295704599595854 0.171746328847455 1.0994342291372 0.5 12.2 12 2 decreased circulating glycerol level 0.035482565059285 0.183415914378399 1.0994342291372 0.5 12.2 12 2 abnormal nerve conduction 0.035482565059285 0.183415914378399 1.0994342291372 0.5 12.2 12 2 decreased metastatic potential 0.0426677672910978 0.213496980734706 1.0994342291372 0.5 12.2 12 2 hemolytic anemia 0.0426677672910978 0.213496980734706 1.0994342291372 0.5 12.2 12 2 abnormal long bone epiphysis morphology 0.0514353491096974 0.248057251244315 1.0994342291372 0.5 12.2 12 2 prolonged PR interval 0.0514353491096974 0.248057251244315 1.0994342291372 0.5 12.2 12 2 cleft upper lip 0.0514353491096974 0.248057251244315 1.0994342291372 0.5 12.2 12 2 decreased circulating estradiol level 0.0514353491096974 0.248057251244315 1.0994342291372 0.5 12.2 12 2 pulmonary vascular congestion 0.0514353491096974 0.248057251244315 1.0994342291372 0.5 12.2 12 2 increased mammary gland tumor incidence 0.0514353491096974 0.248057251244315 1.0994342291372 0.5 12.2 12 2 abnormal circulating enzyme level 0.0621854889601743 0.287521196632776 1.0994342291372 0.5 12.2 12 2 abnormal hyoid bone morphology 0.0621854889601743 0.287521196632776 1.0994342291372 0.5 12.2 12 2 abnormal response to tactile stimuli 0.0621854889601743 0.287521196632776 1.0994342291372 0.5 12.2 12 2 abnormal neuron proliferation 0.0621854889601743 0.287521196632776 1.0994342291372 0.5 12.2 12 2 lowered ear position 0.0754443147228645 0.327803900215066 1.0994342291372 0.5 12.2 12 2 abnormal metacarpal bone morphology 0.0754443147228645 0.327803900215066 1.0994342291372 0.5 12.2 12 2 abnormal redox activity 0.0754443147228645 0.327803900215066 1.0994342291372 0.5 12.2 12 2 increased circulating glycerol level 0.0754443147228645 0.327803900215066 1.0994342291372 0.5 12.2 12 2 long tibia 0.0754443147228645 0.327803900215066 1.0994342291372 0.5 12.2 12 2 darkened coat color 0.0754443147228645 0.327803900215066 1.0994342291372 0.5 12.2 12 2 decreased pulmonary respiratory rate 0.0754443147228645 0.327803900215066 1.0994342291372 0.5 12.2 12 2 abnormal sperm axoneme morphology 0.0754443147228645 0.327803900215066 1.0994342291372 0.5 12.2 12 2 small thoracic cage 0.0754443147228645 0.327803900215066 1.0994342291372 0.5 12.2 12 2 abnormal macrophage chemotaxis 0.0754443147228645 0.327803900215066 1.0994342291372 0.5 12.2 12 2 increased adipocyte glucose uptake 0.0754443147228645 0.327803900215066 1.0994342291372 0.5 12.2 12 2 failure of tooth eruption 0.0919177419560431 0.348996485632201 1.0994342291372 0.5 12.2 12 2 intraventricular hemorrhage 0.0919177419560431 0.348996485632201 1.0994342291372 0.5 12.2 12 2 abnormal olfaction 0.0919177419560431 0.348996485632201 1.0994342291372 0.5 12.2 12 2 increased pancreatic beta cell number 0.0919177419560431 0.348996485632201 1.0994342291372 0.5 12.2 12 2 increased cochlear outer hair cell number 0.0919177419560431 0.348996485632201 1.0994342291372 0.5 12.2 12 2 small epididymis 0.0919177419560431 0.348996485632201 1.0994342291372 0.5 12.2 12 2 abnormal amnion morphology 0.0919177419560431 0.348996485632201 1.0994342291372 0.5 12.2 12 2 abnormal level of surface class II molecules 0.0919177419560431 0.348996485632201 1.0994342291372 0.5 12.2 12 2 abnormal Langerhans cell physiology 0.0919177419560431 0.348996485632201 1.0994342291372 0.5 12.2 12 2 decreased creatinine clearance 0.0919177419560431 0.348996485632201 1.0994342291372 0.5 12.2 12 2 decreased midbrain size 0.0919177419560431 0.348996485632201 1.0994342291372 0.5 12.2 12 2 decreased fibroblast apoptosis 0.0919177419560431 0.348996485632201 1.0994342291372 0.5 12.2 12 2 abnormal kidney blood vessel morphology 0.112578239562594 0.393503770042863 1.0994342291372 0.5 12.2 12 2 abnormal adrenal gland secretion 0.112578239562594 0.393503770042863 1.0994342291372 0.5 12.2 12 2 increased lactate dehydrogenase level 0.112578239562594 0.393503770042863 1.0994342291372 0.5 12.2 12 2 abnormal ventral body wall morphology 0.112578239562594 0.393503770042863 1.0994342291372 0.5 12.2 12 2 absent olfactory bulb 0.112578239562594 0.393503770042863 1.0994342291372 0.5 12.2 12 2 decreased CNS synapse formation 0.112578239562594 0.393503770042863 1.0994342291372 0.5 12.2 12 2 abnormal glucose tolerance 0.112578239562594 0.393503770042863 1.0994342291372 0.5 12.2 12 2 increased pulmonary respiratory rate 0.112578239562594 0.393503770042863 1.0994342291372 0.5 12.2 12 2 pulmonary alveolar hemorrhage 0.112578239562594 0.393503770042863 1.0994342291372 0.5 12.2 12 2 decreased compact bone area 0.112578239562594 0.393503770042863 1.0994342291372 0.5 12.2 12 2 abnormal renal tubule epithelial cell primary cilium morphology 0.112578239562594 0.393503770042863 1.0994342291372 0.5 12.2 12 2 abnormal adipose tissue distribution 0.138813416855703 0.458563578258382 1.0994342291372 0.5 12.2 12 2 abnormal supraoccipital bone morphology 0.138813416855703 0.458563578258382 1.0994342291372 0.5 12.2 12 2 abnormal mineral level 0.138813416855703 0.458563578258382 1.0994342291372 0.5 12.2 12 2 mesocardia 0.138813416855703 0.458563578258382 1.0994342291372 0.5 12.2 12 2 abnormal mating frequency 0.138813416855703 0.458563578258382 1.0994342291372 0.5 12.2 12 2 abnormal pilomotor reflex 0.138813416855703 0.458563578258382 1.0994342291372 0.5 12.2 12 2 increased papilloma incidence 0.138813416855703 0.458563578258382 1.0994342291372 0.5 12.2 12 2 abnormal respiratory function 0.138813416855703 0.458563578258382 1.0994342291372 0.5 12.2 12 2 decreased synaptic depression 0.138813416855703 0.458563578258382 1.0994342291372 0.5 12.2 12 2 small thyroid gland 0.138813416855703 0.458563578258382 1.0994342291372 0.5 12.2 12 2 dilated bile duct 0.138813416855703 0.458563578258382 1.0994342291372 0.5 12.2 12 2 abnormal defecation 0.138813416855703 0.458563578258382 1.0994342291372 0.5 12.2 12 2 pale placenta 0.138813416855703 0.458563578258382 1.0994342291372 0.5 12.2 12 2 stria vascularis degeneration 0.138813416855703 0.458563578258382 1.0994342291372 0.5 12.2 12 2 abnormal cochlear outer hair cell physiology 0.138813416855703 0.458563578258382 1.0994342291372 0.5 12.2 12 2 hematuria 0.138813416855703 0.458563578258382 1.0994342291372 0.5 12.2 12 2 abnormal fatty acid level 0.138813416855703 0.458563578258382 1.0994342291372 0.5 12.2 12 2 decreased oligodendrocyte number 0.138813416855703 0.458563578258382 1.0994342291372 0.5 12.2 12 2 increased skeletal muscle glycogen level 0.138813416855703 0.458563578258382 1.0994342291372 0.5 12.2 12 2 abnormal pulmonary valve cusp morphology 0.138813416855703 0.458563578258382 1.0994342291372 0.5 12.2 12 2 abnormal auchene hair morphology 0.172701220053877 0.532664953358982 1.0994342291372 0.5 12.2 12 2 retarded hair growth 0.172701220053877 0.532664953358982 1.0994342291372 0.5 12.2 12 2 abnormal prostate gland epithelium morphology 0.172701220053877 0.532664953358982 1.0994342291372 0.5 12.2 12 2 absent trophoblast giant cells 0.172701220053877 0.532664953358982 1.0994342291372 0.5 12.2 12 2 abnormal airway responsiveness 0.172701220053877 0.532664953358982 1.0994342291372 0.5 12.2 12 2 ketoaciduria 0.172701220053877 0.532664953358982 1.0994342291372 0.5 12.2 12 2 increased left ventricle diastolic pressure 0.172701220053877 0.532664953358982 1.0994342291372 0.5 12.2 12 2 increased heart rate variability 0.172701220053877 0.532664953358982 1.0994342291372 0.5 12.2 12 2 abnormal reproductive system development 0.172701220053877 0.532664953358982 1.0994342291372 0.5 12.2 12 2 abnormal plasma membrane morphology 0.172701220053877 0.532664953358982 1.0994342291372 0.5 12.2 12 2 abnormal respiratory conducting tube morphology 0.172701220053877 0.532664953358982 1.0994342291372 0.5 12.2 12 2 tachypnea 0.172701220053877 0.532664953358982 1.0994342291372 0.5 12.2 12 2 abnormal developmental vascular remodeling 0.172701220053877 0.532664953358982 1.0994342291372 0.5 12.2 12 2 abnormal sperm principal piece morphology 0.172701220053877 0.532664953358982 1.0994342291372 0.5 12.2 12 2 protruding tongue 0.172701220053877 0.532664953358982 1.0994342291372 0.5 12.2 12 2 abnormal cerebellar granule cell migration 0.172701220053877 0.532664953358982 1.0994342291372 0.5 12.2 12 2 abnormal vibrissa follicle morphology 0.172701220053877 0.532664953358982 1.0994342291372 0.5 12.2 12 2 common ventricle 0.172701220053877 0.532664953358982 1.0994342291372 0.5 12.2 12 2 aorta stenosis 0.172701220053877 0.532664953358982 1.0994342291372 0.5 12.2 12 2 fusion of atlas and odontoid process 0.172701220053877 0.532664953358982 1.0994342291372 0.5 12.2 12 2 decreased trabecular bone connectivity density 0.172701220053877 0.532664953358982 1.0994342291372 0.5 12.2 12 2 abnormal adaptive thermogenesis 0.172701220053877 0.532664953358982 1.0994342291372 0.5 12.2 12 2 decreased bone mineral density 2.98839158175327e-10 1.70887909416351e-08 1.09116780636173 0.496240601503759 12.2 12 2 increased mean corpuscular hemoglobin 0.000115211105101822 0.00202535423279706 1.08832883288329 0.494949494949495 12.2 12 2 abnormal visceral yolk sac morphology 0.000586796916472018 0.00780967887621011 1.08551734016078 0.493670886075949 12.2 12 2 decreased percent body fat/body weight 0.000960710275341719 0.0114892635091948 1.08437348627231 0.493150684931507 12.2 12 2 skin lesions 0.00219906628590306 0.0226252061018711 1.08198289216677 0.492063492063492 12.2 12 2 decreased susceptibility to hepatic steatosis 0.00219906628590306 0.0226252061018711 1.08198289216677 0.492063492063492 12.2 12 2 abnormal male meiosis 0.0025981722962122 0.0256632639890602 1.08141071718413 0.491803278688525 12.2 12 2 increased circulating calcium level 0.00429699145377497 0.0393693047560414 1.07944451588016 0.490909090909091 12.2 12 2 abnormal rostral-caudal axis patterning 0.00429699145377497 0.0393693047560414 1.07944451588016 0.490909090909091 12.2 12 2 abnormal placenta development 0.00508683266918753 0.0445919821987034 1.07869018707801 0.490566037735849 12.2 12 2 abnormal enzyme/coenzyme activity 2.4323398533057e-06 6.61250861759337e-05 1.07842593176515 0.490445859872611 12.2 12 2 abnormal cervical vertebrae morphology 0.00602537183643303 0.0506355150105648 1.07787669523255 0.490196078431373 12.2 12 2 small lung 0.00602537183643303 0.0506355150105648 1.07787669523255 0.490196078431373 12.2 12 2 prenatal lethality, incomplete penetrance 7.13223824136622e-11 4.54908785266627e-09 1.0777348693516 0.490131578947368 12.2 12 2 decreased body weight 6.08704535708594e-40 6.05661013030051e-37 1.07634433417955 0.489499192245557 12.2 12 2 abnormal tibia morphology 0.00847028609350268 0.067505964547098 1.07604201149598 0.48936170212766 12.2 12 2 neuron degeneration 0.00847028609350268 0.067505964547098 1.07604201149598 0.48936170212766 12.2 12 2 increased heart weight 1.01858133757254e-05 0.000236796362356232 1.07570543282489 0.489208633093525 12.2 12 2 limb grasping 4.93044011160771e-07 1.6800643530992e-05 1.07527083948583 0.489010989010989 12.2 12 2 albuminuria 0.010053624859474 0.074875424664496 1.07500235737859 0.488888888888889 12.2 12 2 abnormal male reproductive system morphology 0.0119424962319477 0.0868624543186257 1.07386599125029 0.488372093023256 12.2 12 2 abnormal mammary gland development 0.0141986513358993 0.094943938704434 1.07261876013385 0.48780487804878 12.2 12 2 increased circulating alanine transaminase level 0.000945446081773751 0.0114650068044051 1.07124360787727 0.487179487179487 12.2 12 2 decreased trabecular bone volume 0.0168972025313896 0.110609977096925 1.07124360787727 0.487179487179487 12.2 12 2 male infertility 1.64227587443921e-16 2.59749283753789e-14 1.07101942798654 0.487077534791252 12.2 12 2 increased erythroid progenitor cell number 0.0201298169051522 0.127581682941564 1.06971979051187 0.486486486486487 12.2 12 2 abnormal calcium ion homeostasis 0.0201298169051522 0.127581682941564 1.06971979051187 0.486486486486487 12.2 12 2 weight loss 1.25441519680132e-06 3.67100917887446e-05 1.06802182259042 0.485714285714286 12.2 12 2 thick epidermis 0.00182601835502475 0.0195415635345409 1.06802182259042 0.485714285714286 12.2 12 2 holoprosencephaly 0.0240087869326554 0.146736750601917 1.06802182259042 0.485714285714286 12.2 12 2 abnormal behavior 1.17323305156404e-09 6.2761660554098e-08 1.06779583405411 0.485611510791367 12.2 12 2 decreased bone mineral content 1.35379263640012e-07 5.0262077358885e-06 1.06771978021978 0.485576923076923 12.2 12 2 abnormal tooth development 0.0286722663984821 0.171746328847455 1.06611804037547 0.484848484848485 12.2 12 2 abnormal brain morphology 3.79677139029584e-06 9.78701433508901e-05 1.06529030897766 0.484472049689441 12.2 12 2 abnormal eyelid morphology 0.0342910758207528 0.18240786367654 1.06396860884245 0.483870967741935 12.2 12 2 abnormal object recognition memory 0.0342910758207528 0.18240786367654 1.06396860884245 0.483870967741935 12.2 12 2 small ovary 0.000480985796611826 0.00661023297829788 1.06318914466015 0.483516483516484 12.2 12 2 intracranial hemorrhage 0.00418953606737754 0.03852669488947 1.06278642149929 0.483333333333333 12.2 12 2 decreased granulocyte number 0.0410776556144743 0.207263018947271 1.06152270399454 0.482758620689655 12.2 12 2 increased susceptibility to induced arthritis 0.0410776556144743 0.207263018947271 1.06152270399454 0.482758620689655 12.2 12 2 enlarged epididymis 0.0410776556144743 0.207263018947271 1.06152270399454 0.482758620689655 12.2 12 2 decreased bone strength 0.0410776556144743 0.207263018947271 1.06152270399454 0.482758620689655 12.2 12 2 diluted coat color 0.00693133290286041 0.0572491538099374 1.05871444287286 0.481481481481481 12.2 12 2 abnormal neuronal precursor proliferation 0.00693133290286041 0.0572491538099374 1.05871444287286 0.481481481481481 12.2 12 2 increased brain weight 0.0492980122860435 0.240448638355948 1.05871444287286 0.481481481481481 12.2 12 2 abnormal nervous system morphology 0.00127785262522414 0.0147844576988141 1.05768356220794 0.481012658227848 12.2 12 2 eyelids open at birth 0.00820646367038696 0.0659566345075527 1.05714829724731 0.480769230769231 12.2 12 2 abnormal female meiosis 0.00820646367038696 0.0659566345075527 1.05714829724731 0.480769230769231 12.2 12 2 short stride length 0.00972190398464369 0.0729509386479674 1.05545685997171 0.48 12.2 12 2 decreased oocyte number 0.00972190398464369 0.0729509386479674 1.05545685997171 0.48 12.2 12 2 abnormal cochlear outer hair cell morphology 0.0592879242634665 0.277476409417447 1.05545685997171 0.48 12.2 12 2 decreased placenta weight 0.0592879242634665 0.277476409417447 1.05545685997171 0.48 12.2 12 2 polydactyly 0.000397547486645106 0.0058514755800574 1.0545593626418 0.479591836734694 12.2 12 2 overriding aortic valve 0.0115245056085016 0.0844394924923347 1.05362446958982 0.479166666666667 12.2 12 2 small heart 0.0115245056085016 0.0844394924923347 1.05362446958982 0.479166666666667 12.2 12 2 perimembraneous ventricular septal defect 0.00290395886756196 0.0284393609569306 1.05163274091384 0.478260869565217 12.2 12 2 abnormal sacral vertebrae morphology 0.0714753595513508 0.315239285255293 1.05163274091384 0.478260869565217 12.2 12 2 abnormal vertebral artery topology 0.0714753595513508 0.315239285255293 1.05163274091384 0.478260869565217 12.2 12 2 thin ventricular wall 0.000758595324969796 0.00975196832487012 1.05057048561999 0.477777777777778 12.2 12 2 internal hemorrhage 0.00342512695257896 0.0323954497891261 1.05020583081762 0.477611940298507 12.2 12 2 cochlear hair cell degeneration 0.0162286385408025 0.10665452673777 1.0494599459946 0.477272727272727 12.2 12 2 lethality, incomplete penetrance 0.0162286385408025 0.10665452673777 1.0494599459946 0.477272727272727 12.2 12 2 abnormal lipid homeostasis 6.41413924409635e-05 0.00126597427171043 1.04869111086933 0.476923076923077 12.2 12 2 decreased monocyte cell number 0.00404117769206623 0.0375090653321446 1.04869111086933 0.476923076923077 12.2 12 2 liver degeneration 0.0864122130159791 0.348996485632201 1.0470802182259 0.476190476190476 12.2 12 2 decreased cochlear outer hair cell number 0.0864122130159791 0.348996485632201 1.0470802182259 0.476190476190476 12.2 12 2 increased keratinocyte proliferation 0.0864122130159791 0.348996485632201 1.0470802182259 0.476190476190476 12.2 12 2 abnormal tumor vascularization 0.0864122130159791 0.348996485632201 1.0470802182259 0.476190476190476 12.2 12 2 vascular ring 0.0864122130159791 0.348996485632201 1.0470802182259 0.476190476190476 12.2 12 2 increased bone ossification 0.0864122130159791 0.348996485632201 1.0470802182259 0.476190476190476 12.2 12 2 abnormal eye morphology 4.51083448508803e-05 0.000912252096069632 1.0440670377418 0.474820143884892 12.2 12 2 increased hemoglobin content 0.00665212523830739 0.0552943883219773 1.04353079375734 0.474576271186441 12.2 12 2 increased urine protein level 0.00201004031621943 0.0214099289804158 1.04305298661734 0.474358974358974 12.2 12 2 enlarged heart 1.83766458153975e-07 6.6732710169053e-06 1.04256694142321 0.474137931034483 12.2 12 2 abnormal facial morphology 0.00786075261605383 0.0634175384248959 1.04156926970893 0.473684210526316 12.2 12 2 incomplete somite formation 0.027288954320272 0.164760373474943 1.04156926970893 0.473684210526316 12.2 12 2 kyphoscoliosis 0.104820499229465 0.369583262697795 1.04156926970893 0.473684210526316 12.2 12 2 abnormal stationary movement 0.104820499229465 0.369583262697795 1.04156926970893 0.473684210526316 12.2 12 2 abnormal neural crest cell migration 0.104820499229465 0.369583262697795 1.04156926970893 0.473684210526316 12.2 12 2 increased left ventricle weight 0.104820499229465 0.369583262697795 1.04156926970893 0.473684210526316 12.2 12 2 abnormal cochlear inner hair cell morphology 0.104820499229465 0.369583262697795 1.04156926970893 0.473684210526316 12.2 12 2 absent amnion 0.104820499229465 0.369583262697795 1.04156926970893 0.473684210526316 12.2 12 2 decreased fertilization frequency 0.104820499229465 0.369583262697795 1.04156926970893 0.473684210526316 12.2 12 2 abnormal joint morphology 0.00929315627100603 0.0718517210559809 1.03946508936608 0.472727272727273 12.2 12 2 abnormal glucose homeostasis 4.46981719367785e-06 0.000114625466693543 1.03902575500878 0.472527472527473 12.2 12 2 abnormal locomotor activation 0.0010072871941238 0.0118750089828576 1.03902575500878 0.472527472527473 12.2 12 2 abnormal retinal blood vessel morphology 0.0325151633752083 0.179936527020758 1.03835454974069 0.472222222222222 12.2 12 2 abnormal coat/ hair morphology 0.0109918484928864 0.0813756640656393 1.03720210295962 0.471698113207547 12.2 12 2 cachexia 0.000507699942081467 0.00686360655395461 1.03600533130236 0.471153846153846 12.2 12 2 postnatal growth retardation 1.3060185039115e-16 2.16581401898657e-14 1.03476162742325 0.470588235294118 12.2 12 2 abnormal dendritic spine morphology 0.0130077103386087 0.091735839360543 1.03476162742325 0.470588235294118 12.2 12 2 abnormal vision 0.0387874095841179 0.197712461763306 1.03476162742325 0.470588235294118 12.2 12 2 increased trabecular bone mass 0.127661866434607 0.43029660265052 1.03476162742325 0.470588235294118 12.2 12 2 delayed heart development 0.127661866434607 0.43029660265052 1.03476162742325 0.470588235294118 12.2 12 2 female infertility 5.3121430773143e-08 2.16622227947858e-06 1.03330284693346 0.469924812030075 12.2 12 2 abnormal craniofacial development 0.01540172239274 0.101622770429551 1.03212192939411 0.469387755102041 12.2 12 2 increased exploration in new environment 0.00225813911320776 0.0231633857488838 1.03156791869663 0.469135802469136 12.2 12 2 increased bone mineral density 0.000352934198740878 0.00543606080103984 1.03132768396941 0.469026548672566 12.2 12 2 neonatal lethality 0.0463293520386772 0.228206461774672 1.03071958981612 0.46875 12.2 12 2 increased fatty acid level 0.0463293520386772 0.228206461774672 1.03071958981612 0.46875 12.2 12 2 abnormal auditory brainstem response waveform shape 0.0463293520386772 0.228206461774672 1.03071958981612 0.46875 12.2 12 2 abnormal vertebrae morphology 0.000484657443725181 0.00664234375353382 1.02882836121096 0.467889908256881 12.2 12 2 prenatal lethality 0.00746495864219826 0.0605842891434524 1.0285029885477 0.467741935483871 12.2 12 2 abnormal heart morphology 5.61760135423761e-07 1.83865570640343e-05 1.02804239607634 0.467532467532468 12.2 12 2 decreased body size 1.70030738919161e-20 4.02810917201347e-18 1.02779189841648 0.467418546365915 12.2 12 2 abnormal eating behavior 0.00880689076287103 0.069326394850132 1.02613861386139 0.466666666666667 12.2 12 2 muscular ventricular septal defect 0.00880689076287103 0.069326394850132 1.02613861386139 0.466666666666667 12.2 12 2 abnormal fontanelle morphology 0.156246541938187 0.4963771048164 1.02613861386139 0.466666666666667 12.2 12 2 absent incisors 0.156246541938187 0.4963771048164 1.02613861386139 0.466666666666667 12.2 12 2 decreased hepatocyte number 0.156246541938187 0.4963771048164 1.02613861386139 0.466666666666667 12.2 12 2 decreased salivation 0.156246541938187 0.4963771048164 1.02613861386139 0.466666666666667 12.2 12 2 vagina atresia 0.156246541938187 0.4963771048164 1.02613861386139 0.466666666666667 12.2 12 2 abnormal prostate gland morphology 0.156246541938187 0.4963771048164 1.02613861386139 0.466666666666667 12.2 12 2 audiogenic seizures 0.156246541938187 0.4963771048164 1.02613861386139 0.466666666666667 12.2 12 2 placental labyrinth hypoplasia 0.156246541938187 0.4963771048164 1.02613861386139 0.466666666666667 12.2 12 2 abnormal cricoid cartilage morphology 0.156246541938187 0.4963771048164 1.02613861386139 0.466666666666667 12.2 12 2 abnormal bronchus morphology 0.156246541938187 0.4963771048164 1.02613861386139 0.466666666666667 12.2 12 2 joint inflammation 0.156246541938187 0.4963771048164 1.02613861386139 0.466666666666667 12.2 12 2 abnormal pericyte morphology 0.156246541938187 0.4963771048164 1.02613861386139 0.466666666666667 12.2 12 2 abnormal olfactory nerve morphology 0.156246541938187 0.4963771048164 1.02613861386139 0.466666666666667 12.2 12 2 abnormal energy homeostasis 0.156246541938187 0.4963771048164 1.02613861386139 0.466666666666667 12.2 12 2 abnormal cerebral aqueduct morphology 0.156246541938187 0.4963771048164 1.02613861386139 0.466666666666667 12.2 12 2 absent chorion 0.156246541938187 0.4963771048164 1.02613861386139 0.466666666666667 12.2 12 2 heterochrony 0.156246541938187 0.4963771048164 1.02613861386139 0.466666666666667 12.2 12 2 decreased circulating glucose level 5.41960414842649e-08 2.19207566166031e-06 1.02456236407051 0.46594982078853 12.2 12 2 abnormal suckling behavior 0.00182556700937531 0.0195415635345409 1.0244728044233 0.465909090909091 12.2 12 2 abnormal left-right axis patterning 0.0256617959547921 0.156072658771504 1.02272951547646 0.465116279069767 12.2 12 2 perinatal lethality, complete penetrance 2.24762985374392e-06 6.17787763667181e-05 1.02200928342331 0.464788732394366 12.2 12 2 shortened head 0.0663952243023076 0.301934406676399 1.02090321277026 0.464285714285714 12.2 12 2 abnormal somite shape 0.0663952243023076 0.301934406676399 1.02090321277026 0.464285714285714 12.2 12 2 abnormal ovulation 0.0663952243023076 0.301934406676399 1.02090321277026 0.464285714285714 12.2 12 2 hypoxia 0.0663952243023076 0.301934406676399 1.02090321277026 0.464285714285714 12.2 12 2 decreased body length 1.10961306193839e-07 4.1820643811693e-06 1.01918355547755 0.463503649635036 12.2 12 2 thick ventricular wall 0.0304650358588119 0.171746328847455 1.01898782212716 0.463414634146341 12.2 12 2 lethality at weaning, incomplete penetrance 0.0304650358588119 0.171746328847455 1.01898782212716 0.463414634146341 12.2 12 2 decreased birth weight 0.00147308854772155 0.0165805781106668 1.01842328593762 0.463157894736842 12.2 12 2 abnormal bone mineralization 0.000373248139764174 0.00557630479077107 1.01765812944931 0.462809917355372 12.2 12 2 maternal effect 0.00704198255412676 0.0579072119120341 1.01738689860457 0.462686567164179 12.2 12 2 insulin resistance 0.000221097855699308 0.00365435824619288 1.01614375723287 0.462121212121212 12.2 12 2 neonatal lethality, incomplete penetrance 3.22874713357422e-07 1.12328790136586e-05 1.01486236535741 0.461538461538462 12.2 12 2 abnormal cornea morphology 0.00407565023067904 0.0376884012967067 1.01486236535741 0.461538461538462 12.2 12 2 distended pericardium 0.0171230646256559 0.111396851617721 1.01486236535741 0.461538461538462 12.2 12 2 increased susceptibility to otitis media 0.0796925178670505 0.338283943918099 1.01486236535741 0.461538461538462 12.2 12 2 abnormal pulmonary alveolus epithelial cell morphology 0.192412840323116 0.56668284527701 1.01486236535741 0.461538461538462 12.2 12 2 small otic vesicle 0.192412840323116 0.56668284527701 1.01486236535741 0.461538461538462 12.2 12 2 abnormal vertebral arch development 0.192412840323116 0.56668284527701 1.01486236535741 0.461538461538462 12.2 12 2 increased circulating ammonia level 0.192412840323116 0.56668284527701 1.01486236535741 0.461538461538462 12.2 12 2 small pituitary gland 0.192412840323116 0.56668284527701 1.01486236535741 0.461538461538462 12.2 12 2 increased prostaglandin level 0.192412840323116 0.56668284527701 1.01486236535741 0.461538461538462 12.2 12 2 abnormal aorta tunica media morphology 0.192412840323116 0.56668284527701 1.01486236535741 0.461538461538462 12.2 12 2 ataxia 7.27920297645185e-06 0.00017579628547499 1.0123503297996 0.46039603960396 12.2 12 2 enlarged liver 0.00138985972442975 0.0157289166106763 1.01147949080622 0.46 12.2 12 2 abnormal liver physiology 0.00138985972442975 0.0157289166106763 1.01147949080622 0.46 12.2 12 2 kidney inflammation 0.020240086221859 0.128109960500952 1.01147949080622 0.46 12.2 12 2 impaired glucose tolerance 8.04578406555267e-07 2.54953985516717e-05 1.01077017840033 0.459677419354839 12.2 12 2 abnormal long bone metaphysis morphology 0.0430427078747559 0.213496980734706 1.01029091326121 0.459459459459459 12.2 12 2 increased circulating phosphate level 0.0430427078747559 0.213496980734706 1.01029091326121 0.459459459459459 12.2 12 2 abnormal humerus morphology 0.0430427078747559 0.213496980734706 1.01029091326121 0.459459459459459 12.2 12 2 abnormal maternal nurturing 0.0115009839683407 0.0844394924923347 1.00931666937186 0.459016393442623 12.2 12 2 abnormal renal glomerulus morphology 0.000955496882032123 0.0114650068044051 1.00865525608917 0.458715596330275 12.2 12 2 abnormal cardiovascular system physiology 0.000284921354348372 0.00451427942001003 1.00850357860706 0.458646616541353 12.2 12 2 abnormal intestinal epithelium morphology 0.0239354094904688 0.146468219206743 1.00781471004243 0.458333333333333 12.2 12 2 curly tail 0.0239354094904688 0.146468219206743 1.00781471004243 0.458333333333333 12.2 12 2 abnormal foregut morphology 0.0958510145407956 0.348996485632201 1.00781471004243 0.458333333333333 12.2 12 2 decreased body height 0.0958510145407956 0.348996485632201 1.00781471004243 0.458333333333333 12.2 12 2 curly vibrissae 0.0958510145407956 0.348996485632201 1.00781471004243 0.458333333333333 12.2 12 2 abnormal vasodilation 0.0958510145407956 0.348996485632201 1.00781471004243 0.458333333333333 12.2 12 2 abnormal impulse conducting system conduction 0.0958510145407956 0.348996485632201 1.00781471004243 0.458333333333333 12.2 12 2 abnormal lung saccule morphology 0.0958510145407956 0.348996485632201 1.00781471004243 0.458333333333333 12.2 12 2 infertility 0.00111749429428437 0.0130505495635323 1.00695845285463 0.457943925233645 12.2 12 2 abnormal thoracic vertebrae morphology 0.0135505119361093 0.093112979118983 1.00626183683744 0.457627118644068 12.2 12 2 increased circulating HDL cholesterol level 0.00130692895730569 0.0150508600986014 1.00519700949687 0.457142857142857 12.2 12 2 thick pulmonary interalveolar septum 0.0512325655011392 0.248057251244315 1.00519700949687 0.457142857142857 12.2 12 2 ovary cysts 0.0512325655011392 0.248057251244315 1.00519700949687 0.457142857142857 12.2 12 2 decreased bone volume 0.0512325655011392 0.248057251244315 1.00519700949687 0.457142857142857 12.2 12 2 abnormal craniofacial bone morphology 0.0159693380174109 0.105228419386251 1.00299263009008 0.456140350877193 12.2 12 2 hunched posture 0.00526497923746589 0.0457924330531343 1.00201600630226 0.455696202531646 12.2 12 2 abnormal myocardium layer morphology 0.00526497923746589 0.0457924330531343 1.00201600630226 0.455696202531646 12.2 12 2 abnormal motor coordination/ balance 0.00209026389469532 0.0221256656938494 0.999485662852 0.454545454545455 12.2 12 2 abnormal neuron morphology 0.00209026389469532 0.0221256656938494 0.999485662852 0.454545454545455 12.2 12 2 abnormal gametogenesis 0.0335227604664499 0.18240786367654 0.999485662852 0.454545454545455 12.2 12 2 abnormal astrocyte morphology 0.0335227604664499 0.18240786367654 0.999485662852 0.454545454545455 12.2 12 2 omphalocele 0.0335227604664499 0.18240786367654 0.999485662852 0.454545454545455 12.2 12 2 abnormal tail movements 0.115559599604547 0.393503770042863 0.999485662852 0.454545454545455 12.2 12 2 abnormal oogenesis 0.115559599604547 0.393503770042863 0.999485662852 0.454545454545455 12.2 12 2 decreased airway responsiveness 0.115559599604547 0.393503770042863 0.999485662852 0.454545454545455 12.2 12 2 aphakia 0.115559599604547 0.393503770042863 0.999485662852 0.454545454545455 12.2 12 2 parakeratosis 0.115559599604547 0.393503770042863 0.999485662852 0.454545454545455 12.2 12 2 abnormal female reproductive system physiology 0.115559599604547 0.393503770042863 0.999485662852 0.454545454545455 12.2 12 2 abnormal limb posture 0.115559599604547 0.393503770042863 0.999485662852 0.454545454545455 12.2 12 2 abnormal cerebral cortex pyramidal cell morphology 0.115559599604547 0.393503770042863 0.999485662852 0.454545454545455 12.2 12 2 rough coat 0.115559599604547 0.393503770042863 0.999485662852 0.454545454545455 12.2 12 2 premature suture closure 0.238842076764417 0.627701707291588 0.999485662852 0.454545454545455 12.2 12 2 abnormal hemoglobin 0.238842076764417 0.627701707291588 0.999485662852 0.454545454545455 12.2 12 2 secondary sex reversal 0.238842076764417 0.627701707291588 0.999485662852 0.454545454545455 12.2 12 2 abnormal vestibular ganglion morphology 0.238842076764417 0.627701707291588 0.999485662852 0.454545454545455 12.2 12 2 patent ductus arteriosus 0.238842076764417 0.627701707291588 0.999485662852 0.454545454545455 12.2 12 2 impaired luteinization 0.238842076764417 0.627701707291588 0.999485662852 0.454545454545455 12.2 12 2 dilated renal glomerular capsule 0.238842076764417 0.627701707291588 0.999485662852 0.454545454545455 12.2 12 2 enlarged placenta 0.238842076764417 0.627701707291588 0.999485662852 0.454545454545455 12.2 12 2 abnormal aorta smooth muscle morphology 0.238842076764417 0.627701707291588 0.999485662852 0.454545454545455 12.2 12 2 palatal shelf hypoplasia 0.238842076764417 0.627701707291588 0.999485662852 0.454545454545455 12.2 12 2 aorta dilation 0.238842076764417 0.627701707291588 0.999485662852 0.454545454545455 12.2 12 2 abnormal extraembryonic ectoderm morphology 0.238842076764417 0.627701707291588 0.999485662852 0.454545454545455 12.2 12 2 abnormal dendritic cell chemotaxis 0.238842076764417 0.627701707291588 0.999485662852 0.454545454545455 12.2 12 2 increased subcutaneous adipose tissue amount 0.238842076764417 0.627701707291588 0.999485662852 0.454545454545455 12.2 12 2 hypolactation 0.238842076764417 0.627701707291588 0.999485662852 0.454545454545455 12.2 12 2 thin hypoglossal nerve 0.238842076764417 0.627701707291588 0.999485662852 0.454545454545455 12.2 12 2 increased insulin sensitivity 0.000251876959429594 0.0041084848300401 0.999485662851999 0.454545454545455 12.2 12 2 abnormal locomotor coordination 0.0610435900721735 0.283294646090544 0.999485662851999 0.454545454545455 12.2 12 2 abnormal QRS complex 0.0610435900721735 0.283294646090544 0.999485662851999 0.454545454545455 12.2 12 2 diarrhea 0.0610435900721735 0.283294646090544 0.999485662851999 0.454545454545455 12.2 12 2 decreased circulating LDL cholesterol level 0.0126093853954178 0.0898734847309506 0.996362270155587 0.453125 12.2 12 2 enlarged kidney 0.0221971745286376 0.139433009191884 0.995714018841237 0.452830188679245 12.2 12 2 postnatal lethality, incomplete penetrance 1.34691511254028e-12 1.13574621777761e-10 0.994910552423452 0.452464788732394 12.2 12 2 spina bifida 0.039704248089616 0.201972018656278 0.994726207314609 0.452380952380952 12.2 12 2 absent mature ovarian follicles 0.072815605690842 0.319733131784589 0.993037368252954 0.451612903225806 12.2 12 2 abnormal postnatal growth/weight/body size 0.072815605690842 0.319733131784589 0.993037368252954 0.451612903225806 12.2 12 2 lethargy 0.00334199482608423 0.0317904861563462 0.993037368252954 0.451612903225806 12.2 12 2 microphthalmia 0.000220896153662341 0.00365435824619288 0.991646559613945 0.450980392156863 12.2 12 2 increased circulating free fatty acid level 0.00996567146077412 0.0743316574473032 0.991039305137757 0.450704225352113 12.2 12 2 increased thermal nociceptive threshold 0.00390749132536162 0.0364040624413371 0.990698975706048 0.450549450549451 12.2 12 2 abnormal pancreatic beta cell morphology 0.0470528005227364 0.231540734520884 0.98949080622348 0.45 12.2 12 2 absent placental labyrinth 0.139703689449794 0.460587047722151 0.98949080622348 0.45 12.2 12 2 abnormal optic stalk morphology 0.139703689449794 0.460587047722151 0.98949080622348 0.45 12.2 12 2 abnormal circulating cytokine level 0.139703689449794 0.460587047722151 0.98949080622348 0.45 12.2 12 2 hyperkeratosis 0.0116903394494814 0.0852777694445304 0.987897423282701 0.449275362318841 12.2 12 2 increased circulating LDL cholesterol level 0.0308887841626925 0.171746328847455 0.98724706289871 0.448979591836735 12.2 12 2 abnormal parietal bone morphology 0.0869657488611718 0.348996485632201 0.985699653709213 0.448275862068966 12.2 12 2 abnormal outer ear morphology 0.0869657488611718 0.348996485632201 0.985699653709213 0.448275862068966 12.2 12 2 abnormal blood vessel morphology 0.000404735192981617 0.00585444308328762 0.985699653709213 0.448275862068966 12.2 12 2 increased blood urea nitrogen level 0.000404735192981617 0.00585444308328762 0.985699653709213 0.448275862068966 12.2 12 2 decreased circulating cholesterol level 7.91391779777078e-05 0.00147459704284306 0.985285320101097 0.448087431693989 12.2 12 2 no abnormal phenotype detected 5.46550267013753e-34 3.90078896672785e-31 0.984738208691186 0.447838616714697 12.2 12 2 decreased white adipose tissue amount 0.0137138852264057 0.0939658331171059 0.984567966391522 0.447761194029851 12.2 12 2 decreased grip strength 1.82201269509487e-05 0.000395830268912532 0.983968533839685 0.447488584474886 12.2 12 2 decreased total retina thickness 0.0557957464664812 0.266907537183408 0.983704310280652 0.447368421052632 12.2 12 2 cataract 0.00135033978561613 0.0153728614037534 0.98131319625469 0.446280991735537 12.2 12 2 abnormal pulmonary alveolus morphology 0.00336715536869982 0.0319686983955756 0.979693867547999 0.445544554455446 12.2 12 2 abnormal heart valve morphology 0.104008122331857 0.368809984747674 0.977274870344177 0.444444444444444 12.2 12 2 thin epidermis 0.104008122331857 0.368809984747674 0.977274870344177 0.444444444444444 12.2 12 2 abnormal skin appearance 0.104008122331857 0.368809984747674 0.977274870344177 0.444444444444444 12.2 12 2 thick interventricular septum 0.104008122331857 0.368809984747674 0.977274870344177 0.444444444444444 12.2 12 2 abnormal bone trabecula morphology 0.104008122331857 0.368809984747674 0.977274870344177 0.444444444444444 12.2 12 2 abnormal rib morphology 0.000860000524944365 0.0107500065618046 0.977274870344177 0.444444444444444 12.2 12 2 abnormal ovarian follicle morphology 0.0430355484300383 0.213496980734706 0.977274870344177 0.444444444444444 12.2 12 2 increased circulating corticosterone level 0.0430355484300383 0.213496980734706 0.977274870344177 0.444444444444444 12.2 12 2 abnormal metabolism 0.0430355484300383 0.213496980734706 0.977274870344177 0.444444444444444 12.2 12 2 lethality at weaning, complete penetrance 0.0430355484300383 0.213496980734706 0.977274870344177 0.444444444444444 12.2 12 2 heart right ventricle hypertrophy 0.0662064872018844 0.301934406676399 0.977274870344177 0.444444444444444 12.2 12 2 impaired wound healing 0.0662064872018844 0.301934406676399 0.977274870344177 0.444444444444444 12.2 12 2 absent spleen 0.169435907804001 0.5307753227013 0.977274870344177 0.444444444444444 12.2 12 2 abnormal phrenic nerve morphology 0.169435907804001 0.5307753227013 0.977274870344177 0.444444444444444 12.2 12 2 blepharoptosis 0.169435907804001 0.5307753227013 0.977274870344177 0.444444444444444 12.2 12 2 eye inflammation 0.169435907804001 0.5307753227013 0.977274870344177 0.444444444444444 12.2 12 2 abnormal thyroid cartilage morphology 0.169435907804001 0.5307753227013 0.977274870344177 0.444444444444444 12.2 12 2 abnormal white adipose tissue morphology 0.169435907804001 0.5307753227013 0.977274870344177 0.444444444444444 12.2 12 2 abnormal glycogen homeostasis 0.169435907804001 0.5307753227013 0.977274870344177 0.444444444444444 12.2 12 2 decreased tumor latency 0.169435907804001 0.5307753227013 0.977274870344177 0.444444444444444 12.2 12 2 respiratory failure 0.000472467988978367 0.00652924512546493 0.975656865591952 0.443708609271523 12.2 12 2 abnormal myocardial fiber morphology 0.00457612069451204 0.0416963378300319 0.974756120678342 0.443298969072165 12.2 12 2 hyperglycemia 0.00674040928684272 0.0558892270034042 0.9744985212807 0.443181818181818 12.2 12 2 abnormal snout morphology 0.0333648195523048 0.18240786367654 0.972576433467523 0.442307692307692 12.2 12 2 increased circulating creatinine level 0.00786504948907755 0.0634175384248959 0.971593039702641 0.441860465116279 12.2 12 2 delayed endochondral bone ossification 0.0508211893630182 0.247392776008821 0.971593039702641 0.441860465116279 12.2 12 2 decreased oxygen consumption 0.0508211893630182 0.247392776008821 0.971593039702641 0.441860465116279 12.2 12 2 overexpanded pulmonary alveoli 0.0786142588785326 0.337742606149136 0.970089025709294 0.441176470588235 12.2 12 2 decreased osteoblast cell number 0.0786142588785326 0.337742606149136 0.970089025709294 0.441176470588235 12.2 12 2 abnormal skin physiology 0.0786142588785326 0.337742606149136 0.970089025709294 0.441176470588235 12.2 12 2 abnormal keratinocyte physiology 0.124579156901554 0.421619935772268 0.967502121640735 0.44 12.2 12 2 postnatal lethality 0.000375645579511423 0.00559531963493812 0.966972273819465 0.439759036144578 12.2 12 2 abnormal skin morphology 0.0202903878407169 0.128265158205294 0.966169474090266 0.439393939393939 12.2 12 2 retinal degeneration 0.00665755549846521 0.0552943883219773 0.96200495049505 0.4375 12.2 12 2 abnormal kidney physiology 0.046190938628436 0.22820250216134 0.96200495049505 0.4375 12.2 12 2 abnormal crypts of Lieberkuhn morphology 0.0934160251980814 0.348996485632201 0.96200495049505 0.4375 12.2 12 2 abnormal tympanic ring morphology 0.206280053035411 0.599791504296416 0.96200495049505 0.4375 12.2 12 2 poor circulation 0.206280053035411 0.599791504296416 0.96200495049505 0.4375 12.2 12 2 abnormal extraembryonic endoderm formation 0.206280053035411 0.599791504296416 0.96200495049505 0.4375 12.2 12 2 abnormal meiosis 0.206280053035411 0.599791504296416 0.96200495049505 0.4375 12.2 12 2 abnormal epicardium morphology 0.206280053035411 0.599791504296416 0.96200495049505 0.4375 12.2 12 2 paternal imprinting 0.206280053035411 0.599791504296416 0.96200495049505 0.4375 12.2 12 2 small pancreas 0.206280053035411 0.599791504296416 0.96200495049505 0.4375 12.2 12 2 increased thymus weight 0.206280053035411 0.599791504296416 0.96200495049505 0.4375 12.2 12 2 abnormal wound healing 0.206280053035411 0.599791504296416 0.96200495049505 0.4375 12.2 12 2 decreased circulating prolactin level 0.206280053035411 0.599791504296416 0.96200495049505 0.4375 12.2 12 2 dystonia 0.206280053035411 0.599791504296416 0.96200495049505 0.4375 12.2 12 2 loose skin 0.206280053035411 0.599791504296416 0.96200495049505 0.4375 12.2 12 2 abnormal thoracic cage shape 0.206280053035411 0.599791504296416 0.96200495049505 0.4375 12.2 12 2 increased or absent threshold for auditory brainstem response 6.40567388358174e-06 0.000155754975913789 0.958676213642126 0.43598615916955 12.2 12 2 decreased startle reflex 0.00330004542530264 0.0314927390024157 0.958481122837558 0.435897435897436 12.2 12 2 acanthosis 0.070940873628383 0.313700418286376 0.958481122837558 0.435897435897436 12.2 12 2 abnormal response to injury 0.070940873628383 0.313700418286376 0.958481122837558 0.435897435897436 12.2 12 2 abnormal circulating hormone level 0.070940873628383 0.313700418286376 0.958481122837558 0.435897435897436 12.2 12 2 abnormal locomotor behavior 0.00900453177946693 0.0703258172729167 0.95602976446713 0.434782608695652 12.2 12 2 abnormal forelimb morphology 0.0543559144919191 0.26052088111493 0.95602976446713 0.434782608695652 12.2 12 2 abnormal carpal bone morphology 0.149470553491622 0.480372095362285 0.95602976446713 0.434782608695652 12.2 12 2 abnormal circulating insulin level 0.149470553491622 0.480372095362285 0.95602976446713 0.434782608695652 12.2 12 2 decreased epididymis weight 0.149470553491622 0.480372095362285 0.95602976446713 0.434782608695652 12.2 12 2 increased circulating triglyceride level 0.00131269362959917 0.0150823344278427 0.955370433595084 0.43448275862069 12.2 12 2 decreased litter size 1.13028671938965e-05 0.000260186506453505 0.954668868005255 0.434163701067616 12.2 12 2 impaired coordination 1.34042835989019e-06 3.89978426342322e-05 0.953266672662312 0.433526011560694 12.2 12 2 kidney cysts 0.0197721766368427 0.126110998420888 0.950862036010551 0.432432432432432 12.2 12 2 abnormal vocalization 0.0838550809749343 0.348996485632201 0.950862036010551 0.432432432432432 12.2 12 2 decreased circulating chloride level 0.0838550809749343 0.348996485632201 0.950862036010551 0.432432432432432 12.2 12 2 abnormal neuromuscular synapse morphology 0.0230359900536894 0.144051564087763 0.946735030645922 0.430555555555556 12.2 12 2 cochlear outer hair cell degeneration 0.0230359900536894 0.144051564087763 0.946735030645922 0.430555555555556 12.2 12 2 abnormal gait 7.98090690438429e-06 0.000188175411608113 0.94643852734788 0.43042071197411 12.2 12 2 hypoglycemia 0.011109781945725 0.081762078668612 0.945749874526623 0.43010752688172 12.2 12 2 decreased circulating HDL cholesterol level 0.00341776003835758 0.0323873451253885 0.944826290664781 0.4296875 12.2 12 2 abnormal lung morphology 0.00498910141916576 0.0440084743977831 0.942372196403314 0.428571428571429 12.2 12 2 abnormal muscle morphology 0.0752822403655599 0.327803900215066 0.942372196403314 0.428571428571429 12.2 12 2 reddish skin 0.132217795854018 0.444448334036312 0.942372196403314 0.428571428571429 12.2 12 2 prolonged QRS complex duration 0.132217795854018 0.444448334036312 0.942372196403314 0.428571428571429 12.2 12 2 abnormal scapula morphology 0.179672296775155 0.536977538938533 0.942372196403314 0.428571428571429 12.2 12 2 abnormal associative learning 0.179672296775155 0.536977538938533 0.942372196403314 0.428571428571429 12.2 12 2 complete atrioventricular septal defect 0.179672296775155 0.536977538938533 0.942372196403314 0.428571428571429 12.2 12 2 midline facial cleft 0.252288790893508 0.64186440054419 0.942372196403314 0.428571428571429 12.2 12 2 abnormal blood flow velocity 0.252288790893508 0.64186440054419 0.942372196403314 0.428571428571429 12.2 12 2 absent visceral yolk sac blood islands 0.252288790893508 0.64186440054419 0.942372196403314 0.428571428571429 12.2 12 2 absent otoliths 0.252288790893508 0.64186440054419 0.942372196403314 0.428571428571429 12.2 12 2 intestinal obstruction 0.252288790893508 0.64186440054419 0.942372196403314 0.428571428571429 12.2 12 2 abnormal sagittal suture morphology 0.252288790893508 0.64186440054419 0.942372196403314 0.428571428571429 12.2 12 2 abnormal iris pigmentation 0.252288790893508 0.64186440054419 0.942372196403314 0.428571428571429 12.2 12 2 premature hair loss 0.252288790893508 0.64186440054419 0.942372196403314 0.428571428571429 12.2 12 2 sternebra fusion 0.252288790893508 0.64186440054419 0.942372196403314 0.428571428571429 12.2 12 2 multiple persisting craniopharyngeal ducts 0.252288790893508 0.64186440054419 0.942372196403314 0.428571428571429 12.2 12 2 domed cranium 0.0268300932709301 0.162978893800827 0.942372196403314 0.428571428571429 12.2 12 2 abnormal artery morphology 0.0991505289115777 0.353601348627311 0.942372196403314 0.428571428571429 12.2 12 2 decreased bone mineralization 0.0991505289115777 0.353601348627311 0.942372196403314 0.428571428571429 12.2 12 2 increased startle reflex 0.0149448862811754 0.098739454513742 0.938842712521653 0.426966292134831 12.2 12 2 pulmonary hypoplasia 0.0676164847595809 0.303483791368662 0.93568870564868 0.425531914893617 12.2 12 2 short limbs 0.0173230569662957 0.111779777441402 0.935150953518997 0.425287356321839 12.2 12 2 decreased circulating phosphate level 0.0885972754890782 0.348996485632201 0.93451909476662 0.425 12.2 12 2 abnormal tail morphology 0.036356403823622 0.186083445496419 0.932853285328533 0.424242424242424 12.2 12 2 dextrocardia 0.11726939844875 0.397964022702956 0.932853285328533 0.424242424242424 12.2 12 2 abnormal skeleton physiology 0.11726939844875 0.397964022702956 0.932853285328533 0.424242424242424 12.2 12 2 dilated heart atrium 0.11726939844875 0.397964022702956 0.932853285328533 0.424242424242424 12.2 12 2 abnormal retina morphology 0.00042847465427752 0.00597104035022594 0.931901394221055 0.423809523809524 12.2 12 2 abnormal skin condition 0.0607679530732278 0.283071691516206 0.93029050157763 0.423076923076923 12.2 12 2 abnormal xiphoid process morphology 0.157496025526857 0.499071800634466 0.93029050157763 0.423076923076923 12.2 12 2 ventricular hypoplasia 0.157496025526857 0.499071800634466 0.93029050157763 0.423076923076923 12.2 12 2 abnormal erythrocyte osmotic lysis 0.157496025526857 0.499071800634466 0.93029050157763 0.423076923076923 12.2 12 2 atelectasis 0.032877751407497 0.181740903613664 0.929099348566647 0.422535211267606 12.2 12 2 decreased insulin secretion 0.0182165968482704 0.117241357464612 0.928411126826968 0.422222222222222 12.2 12 2 irregular heartbeat 0.0792647834395282 0.338283943918099 0.928411126826968 0.422222222222222 12.2 12 2 decreased osteoclast cell number 0.0792647834395282 0.338283943918099 0.928411126826968 0.422222222222222 12.2 12 2 cardiomyopathy 0.0792647834395282 0.338283943918099 0.928411126826968 0.422222222222222 12.2 12 2 abnormal axial skeleton morphology 0.0297376040598585 0.171746328847455 0.925839350852379 0.421052631578947 12.2 12 2 abnormal reproductive system physiology 0.104261869708355 0.369446440027824 0.925839350852379 0.421052631578947 12.2 12 2 shiny skin 0.216428932221845 0.611663378108013 0.925839350852379 0.421052631578947 12.2 12 2 short vibrissae 0.216428932221845 0.611663378108013 0.925839350852379 0.421052631578947 12.2 12 2 delayed sexual maturation 0.216428932221845 0.611663378108013 0.925839350852379 0.421052631578947 12.2 12 2 decreased germ cell number 0.216428932221845 0.611663378108013 0.925839350852379 0.421052631578947 12.2 12 2 abnormal nasal septum morphology 0.216428932221845 0.611663378108013 0.925839350852379 0.421052631578947 12.2 12 2 oliguria 0.216428932221845 0.611663378108013 0.925839350852379 0.421052631578947 12.2 12 2 decreased liver regeneration 0.216428932221845 0.611663378108013 0.925839350852379 0.421052631578947 12.2 12 2 increased liver cholesterol level 0.216428932221845 0.611663378108013 0.925839350852379 0.421052631578947 12.2 12 2 decreased liver glycogen level 0.216428932221845 0.611663378108013 0.925839350852379 0.421052631578947 12.2 12 2 abnormal circulating amino acid level 0.0546493252052205 0.261675065347423 0.925839350852378 0.421052631578947 12.2 12 2 abnormal trabecular bone morphology 0.0084806488124495 0.067505964547098 0.923894310199327 0.420168067226891 12.2 12 2 increased circulating chloride level 0.0710003358774792 0.313700418286376 0.923524752475247 0.42 12.2 12 2 abnormal skeleton development 0.026903580316295 0.163225990333619 0.922981821991723 0.419753086419753 12.2 12 2 abnormal nose morphology 0.138734225248891 0.458563578258382 0.922106127663458 0.419354838709677 12.2 12 2 abnormal podocyte morphology 0.138734225248891 0.458563578258382 0.922106127663458 0.419354838709677 12.2 12 2 small cranium 0.138734225248891 0.458563578258382 0.922106127663458 0.419354838709677 12.2 12 2 decreased susceptibility to bacterial infection induced morbidity/mortality 0.138734225248891 0.458563578258382 0.922106127663458 0.419354838709677 12.2 12 2 hypoactivity 7.57017144056866e-06 0.000181065398638601 0.92154168808317 0.419098143236074 12.2 12 2 neonatal lethality, complete penetrance 9.54575370827379e-07 2.92682764370093e-05 0.921017270900022 0.418859649122807 12.2 12 2 abnormal organ of Corti morphology 0.0928941970873898 0.348996485632201 0.920456563928818 0.418604651162791 12.2 12 2 abnormal contextual conditioning behavior 0.0636694138599897 0.292479532736333 0.919526809823839 0.418181818181818 12.2 12 2 abnormal learning/memory/conditioning 0.0636694138599897 0.292479532736333 0.919526809823839 0.418181818181818 12.2 12 2 abnormal kidney morphology 0.00220112557855389 0.0226252061018711 0.917242271165892 0.417142857142857 12.2 12 2 oligodactyly 0.0829204462818274 0.346081560614171 0.916195190947666 0.416666666666667 12.2 12 2 abnormal phalanx morphology 0.0829204462818274 0.346081560614171 0.916195190947666 0.416666666666667 12.2 12 2 abnormal epidermis stratum granulosum morphology 0.122681987275645 0.415481883387565 0.916195190947666 0.416666666666667 12.2 12 2 abnormal adrenal gland morphology 0.187770224170783 0.556045753124789 0.916195190947666 0.416666666666667 12.2 12 2 abnormal body weight 0.187770224170783 0.556045753124789 0.916195190947666 0.416666666666667 12.2 12 2 abnormal nursing 0.187770224170783 0.556045753124789 0.916195190947666 0.416666666666667 12.2 12 2 blindness 0.187770224170783 0.556045753124789 0.916195190947666 0.416666666666667 12.2 12 2 abnormal cardiac muscle contractility 0.187770224170783 0.556045753124789 0.916195190947666 0.416666666666667 12.2 12 2 hypopigmentation 0.187770224170783 0.556045753124789 0.916195190947666 0.416666666666667 12.2 12 2 increased body temperature 0.187770224170783 0.556045753124789 0.916195190947666 0.416666666666667 12.2 12 2 increased circulating total protein level 0.187770224170783 0.556045753124789 0.916195190947666 0.416666666666667 12.2 12 2 abnormal truncus arteriosus septation 0.187770224170783 0.556045753124789 0.916195190947666 0.416666666666667 12.2 12 2 abnormal rectum morphology 0.310291119556356 0.64186440054419 0.916195190947666 0.416666666666667 12.2 12 2 absent optic nerve 0.310291119556356 0.64186440054419 0.916195190947666 0.416666666666667 12.2 12 2 increased circulating parathyroid hormone level 0.310291119556356 0.64186440054419 0.916195190947666 0.416666666666667 12.2 12 2 abnormal aorta elastic fiber morphology 0.310291119556356 0.64186440054419 0.916195190947666 0.416666666666667 12.2 12 2 increased fear-related response 0.310291119556356 0.64186440054419 0.916195190947666 0.416666666666667 12.2 12 2 abnormal nucleotide metabolism 0.310291119556356 0.64186440054419 0.916195190947666 0.416666666666667 12.2 12 2 increased hepatocyte proliferation 0.310291119556356 0.64186440054419 0.916195190947666 0.416666666666667 12.2 12 2 vestibular saccular macula degeneration 0.310291119556356 0.64186440054419 0.916195190947666 0.416666666666667 12.2 12 2 decreased renal glomerular filtration rate 0.310291119556356 0.64186440054419 0.916195190947666 0.416666666666667 12.2 12 2 decreased keratinocyte proliferation 0.310291119556356 0.64186440054419 0.916195190947666 0.416666666666667 12.2 12 2 abnormal retinal pigmentation 0.0293031049202075 0.171746328847455 0.909876603423889 0.413793103448276 12.2 12 2 cochlear ganglion degeneration 0.066384197754526 0.301934406676399 0.909876603423889 0.413793103448276 12.2 12 2 glomerulosclerosis 0.066384197754526 0.301934406676399 0.909876603423889 0.413793103448276 12.2 12 2 focal hair loss 0.164160417260733 0.518209439005171 0.909876603423889 0.413793103448276 12.2 12 2 stomach inflammation 0.164160417260733 0.518209439005171 0.909876603423889 0.413793103448276 12.2 12 2 abnormal hair follicle morphology 0.0595172317238584 0.278287808107327 0.90746952246245 0.412698412698413 12.2 12 2 abnormal posture 0.0374492920903295 0.19148019337039 0.90703323903819 0.4125 12.2 12 2 distended abdomen 0.0862785472293438 0.348996485632201 0.905416423995341 0.411764705882353 12.2 12 2 cochlear inner hair cell degeneration 0.0862785472293438 0.348996485632201 0.905416423995341 0.411764705882353 12.2 12 2 lung hemorrhage 0.144327996147903 0.465046490178637 0.905416423995341 0.411764705882353 12.2 12 2 thin skin 0.144327996147903 0.465046490178637 0.905416423995341 0.411764705882353 12.2 12 2 abnormal endoderm development 0.144327996147903 0.465046490178637 0.905416423995341 0.411764705882353 12.2 12 2 increased width of hypertrophic chondrocyte zone 0.144327996147903 0.465046490178637 0.905416423995341 0.411764705882353 12.2 12 2 abnormal nervous system development 0.144327996147903 0.465046490178637 0.905416423995341 0.411764705882353 12.2 12 2 hydroureter 0.261312783655973 0.64186440054419 0.905416423995341 0.411764705882353 12.2 12 2 increased incidence of corneal inflammation 0.261312783655973 0.64186440054419 0.905416423995341 0.411764705882353 12.2 12 2 aminoaciduria 0.261312783655973 0.64186440054419 0.905416423995341 0.411764705882353 12.2 12 2 abnormal involuntary movement 0.261312783655973 0.64186440054419 0.905416423995341 0.411764705882353 12.2 12 2 common atrium 0.261312783655973 0.64186440054419 0.905416423995341 0.411764705882353 12.2 12 2 abnormal survival 0.261312783655973 0.64186440054419 0.905416423995341 0.411764705882353 12.2 12 2 abnormal electroretinogram waveform feature 0.261312783655973 0.64186440054419 0.905416423995341 0.411764705882353 12.2 12 2 abnormal ductus venosus valve morphology 0.261312783655973 0.64186440054419 0.905416423995341 0.411764705882353 12.2 12 2 cardiac fibrosis 0.0337570052424899 0.18240786367654 0.905416423995341 0.411764705882353 12.2 12 2 increased circulating glucose level 0.00825458238859579 0.0660233880759872 0.904499082127058 0.411347517730496 12.2 12 2 respiratory distress 0.00405919253022397 0.0376061132921122 0.902425783453655 0.410404624277457 12.2 12 2 abnormal heart ventricle morphology 0.0431710184075844 0.213920136033598 0.902099880317702 0.41025641025641 12.2 12 2 abnormal heart looping 0.127441693068335 0.43013732904679 0.902099880317702 0.41025641025641 12.2 12 2 small lens 0.127441693068335 0.43013732904679 0.902099880317702 0.41025641025641 12.2 12 2 abnormal long bone morphology 0.0689242172150181 0.305885798969416 0.901175597653442 0.409836065573771 12.2 12 2 short tail 0.0388598491425223 0.197878965695034 0.900741296160597 0.409638554216867 12.2 12 2 small kidney 0.0350063878583762 0.183415914378399 0.8995370965668 0.409090909090909 12.2 12 2 renal interstitial fibrosis 0.112920029077145 0.393503770042863 0.8995370965668 0.409090909090909 12.2 12 2 decreased sensitivity to induced morbidity/mortality 0.112920029077145 0.393503770042863 0.8995370965668 0.409090909090909 12.2 12 2 abnormal basisphenoid bone morphology 0.22405801020096 0.616413867417968 0.8995370965668 0.409090909090909 12.2 12 2 intestinal ulcer 0.22405801020096 0.616413867417968 0.8995370965668 0.409090909090909 12.2 12 2 abnormal facial nerve morphology 0.22405801020096 0.616413867417968 0.8995370965668 0.409090909090909 12.2 12 2 increased myocardial infarction size 0.22405801020096 0.616413867417968 0.8995370965668 0.409090909090909 12.2 12 2 abnormal retinal layer morphology 0.22405801020096 0.616413867417968 0.8995370965668 0.409090909090909 12.2 12 2 abnormal skeleton morphology 0.0183274148921264 0.117802182284663 0.898667978599102 0.408695652173913 12.2 12 2 abnormal epidermis stratum corneum morphology 0.10033623373292 0.357317654131192 0.897497329907918 0.408163265306122 12.2 12 2 abnormal respiratory system physiology 0.10033623373292 0.357317654131192 0.897497329907918 0.408163265306122 12.2 12 2 short snout 0.0232050034309019 0.144051564087763 0.895835297815496 0.407407407407407 12.2 12 2 abnormal osteoblast physiology 0.0893657203949728 0.348996485632201 0.895835297815496 0.407407407407407 12.2 12 2 abnormal trigeminal nerve morphology 0.194268958973419 0.570873048371389 0.895835297815496 0.407407407407407 12.2 12 2 cryptorchism 0.194268958973419 0.570873048371389 0.895835297815496 0.407407407407407 12.2 12 2 scoliosis 0.16974141475734 0.5307753227013 0.893290311173975 0.40625 12.2 12 2 kidney cortex cysts 0.16974141475734 0.5307753227013 0.893290311173975 0.40625 12.2 12 2 polydipsia 0.16974141475734 0.5307753227013 0.893290311173975 0.40625 12.2 12 2 abnormal lymphatic vessel morphology 0.16974141475734 0.5307753227013 0.893290311173975 0.40625 12.2 12 2 abnormal heart atrium morphology 0.16974141475734 0.5307753227013 0.893290311173975 0.40625 12.2 12 2 pancreatic islet hyperplasia 0.16974141475734 0.5307753227013 0.893290311173975 0.40625 12.2 12 2 abnormal epidermal layer morphology 0.0638393517017088 0.292989644571957 0.892294446835988 0.405797101449275 12.2 12 2 abnormal hair follicle development 0.149154877935219 0.480288360988814 0.891433158759891 0.405405405405405 12.2 12 2 abnormal optic nerve morphology 0.131641167230789 0.443108800387804 0.890018185492019 0.404761904761905 12.2 12 2 postnatal lethality, complete penetrance 8.19218843133362e-05 0.00152075139723451 0.888661863965819 0.404145077720207 12.2 12 2 abnormal heart left ventricle morphology 0.0658144183574491 0.30149791098371 0.885655351249411 0.402777777777778 12.2 12 2 impaired balance 0.0346721513841548 0.183415914378399 0.88385889009069 0.401960784313726 12.2 12 2 hyperactivity 0.000164743954022956 0.00279727362206213 0.883103504805621 0.401617250673854 12.2 12 2 abnormal motor capabilities/coordination/movement 0.0187652329018895 0.120460688628259 0.882879002185933 0.401515151515151 12.2 12 2 increased circulating insulin level 0.0117091389283477 0.0852898479773493 0.87954738330976 0.4 12.2 12 2 abnormal social investigation 0.0606569895395197 0.282819609146308 0.87954738330976 0.4 12.2 12 2 abnormal retinal pigment epithelium morphology 0.0606569895395197 0.282819609146308 0.87954738330976 0.4 12.2 12 2 impaired ovarian folliculogenesis 0.153337971454507 0.492483155575321 0.87954738330976 0.4 12.2 12 2 abnormal basioccipital bone morphology 0.267579094069879 0.64186440054419 0.87954738330976 0.4 12.2 12 2 abnormal postnatal subventricular zone morphology 0.267579094069879 0.64186440054419 0.87954738330976 0.4 12.2 12 2 enhanced behavioral response to xenobiotic 0.267579094069879 0.64186440054419 0.87954738330976 0.4 12.2 12 2 abnormal heart tube morphology 0.199540073317115 0.585325391953212 0.87954738330976 0.4 12.2 12 2 abnormal hair cycle 0.199540073317115 0.585325391953212 0.87954738330976 0.4 12.2 12 2 hyperpigmentation 0.316316956863722 0.647337252322919 0.87954738330976 0.4 12.2 12 2 abnormal epidermis stratum spinosum morphology 0.316316956863722 0.647337252322919 0.87954738330976 0.4 12.2 12 2 abnormal pup retrieval 0.316316956863722 0.647337252322919 0.87954738330976 0.4 12.2 12 2 abnormal seizure response to electrical stimulation 0.316316956863722 0.647337252322919 0.87954738330976 0.4 12.2 12 2 abnormal apical ectodermal ridge morphology 0.316316956863722 0.647337252322919 0.87954738330976 0.4 12.2 12 2 lactation failure 0.316316956863722 0.647337252322919 0.87954738330976 0.4 12.2 12 2 abnormal branching involved in lung morphogenesis 0.316316956863722 0.647337252322919 0.87954738330976 0.4 12.2 12 2 decreased brown adipose tissue mass 0.316316956863722 0.647337252322919 0.87954738330976 0.4 12.2 12 2 impaired fertilization 0.0756064027990725 0.328221513023897 0.879547383309759 0.4 12.2 12 2 increased body length 0.11989349896988 0.406314821100241 0.879547383309759 0.4 12.2 12 2 abnormal circulating protein level 0.11989349896988 0.406314821100241 0.879547383309759 0.4 12.2 12 2 abnormal dermal layer morphology 0.174446307638786 0.536977538938533 0.879547383309759 0.4 12.2 12 2 decreased circulating thyroxine level 0.174446307638786 0.536977538938533 0.879547383309759 0.4 12.2 12 2 decreased acute inflammation 0.229897602350269 0.616413867417968 0.879547383309759 0.4 12.2 12 2 abnormal vertebrae development 0.229897602350269 0.616413867417968 0.879547383309759 0.4 12.2 12 2 cardiac hypertrophy 0.0451202900602554 0.223134635238341 0.87505989666022 0.397959183673469 12.2 12 2 absent gastric milk in neonates 0.0694274102919576 0.307844354904179 0.873909259057774 0.397435897435897 12.2 12 2 increased body weight 0.00432428124097127 0.039473943438224 0.873657557082239 0.397321428571429 12.2 12 2 decreased susceptibility to injury 0.0867631772322083 0.348996485632201 0.873080123138364 0.397058823529412 12.2 12 2 abnormal enzyme/coenzyme level 0.109174643589807 0.384662784602897 0.871965078281227 0.396551724137931 12.2 12 2 kidney failure 0.156975724632241 0.498375386117039 0.869320088154995 0.395348837209302 12.2 12 2 abnormal frontal bone morphology 0.178432926778827 0.536977538938533 0.867974391424105 0.394736842105263 12.2 12 2 abnormal compact bone morphology 0.178432926778827 0.536977538938533 0.867974391424105 0.394736842105263 12.2 12 2 decreased cardiac muscle contractility 0.0472834637711242 0.232445881681169 0.866861603742792 0.394230769230769 12.2 12 2 abnormal epidermis stratum basale morphology 0.203848225357924 0.597258493024542 0.866220907805066 0.393939393939394 12.2 12 2 decreased sensitivity to xenobiotic induced morbidity/mortality 0.203848225357924 0.597258493024542 0.866220907805066 0.393939393939394 12.2 12 2 abnormal neuron differentiation 0.0434924595191059 0.215298493639355 0.863841180036371 0.392857142857143 12.2 12 2 hydronephrosis 0.0726332486566214 0.319496385558525 0.863841180036371 0.392857142857143 12.2 12 2 decreased exploration in new environment 0.0726332486566214 0.319496385558525 0.863841180036371 0.392857142857143 12.2 12 2 increased food intake 0.0726332486566214 0.319496385558525 0.863841180036371 0.392857142857143 12.2 12 2 abnormal seminal vesicle morphology 0.125549256657634 0.424325782521556 0.863841180036371 0.392857142857143 12.2 12 2 enhanced long term potentiation 0.125549256657634 0.424325782521556 0.863841180036371 0.392857142857143 12.2 12 2 abnormal respiration 0.234419711580091 0.621330881785271 0.863841180036371 0.392857142857143 12.2 12 2 abnormal retinal inner nuclear layer morphology 0.234419711580091 0.621330881785271 0.863841180036371 0.392857142857143 12.2 12 2 enhanced coordination 0.234419711580091 0.621330881785271 0.863841180036371 0.392857142857143 12.2 12 2 decreased circulating progesterone level 0.234419711580091 0.621330881785271 0.863841180036371 0.392857142857143 12.2 12 2 abnormal spatial learning 0.0181548506244802 0.116995313285996 0.863359394659887 0.392638036809816 12.2 12 2 abnormal cued conditioning behavior 0.141580564608936 0.462700270727257 0.862301356186039 0.392156862745098 12.2 12 2 abnormal coat appearance 0.101499922216101 0.361203228201075 0.860426788020417 0.391304347826087 12.2 12 2 abnormal sleep pattern 0.160147753399559 0.50715154243336 0.860426788020417 0.391304347826087 12.2 12 2 bidirectional circling 0.272007089514106 0.64186440054419 0.860426788020417 0.391304347826087 12.2 12 2 abnormal postnatal growth 0.272007089514106 0.64186440054419 0.860426788020417 0.391304347826087 12.2 12 2 abnormal nasal cavity morphology 0.272007089514106 0.64186440054419 0.860426788020417 0.391304347826087 12.2 12 2 abnormal cochlear ganglion morphology 0.272007089514106 0.64186440054419 0.860426788020417 0.391304347826087 12.2 12 2 increased susceptibility to fungal infection 0.272007089514106 0.64186440054419 0.860426788020417 0.391304347826087 12.2 12 2 abnormal lens development 0.272007089514106 0.64186440054419 0.860426788020417 0.391304347826087 12.2 12 2 abnormal palatal shelf fusion at midline 0.272007089514106 0.64186440054419 0.860426788020417 0.391304347826087 12.2 12 2 decreased heart rate 0.0608705190973079 0.283284221243318 0.857558698727015 0.39 12.2 12 2 abnormal maxilla morphology 0.144186449945231 0.465046490178637 0.855115511551155 0.388888888888889 12.2 12 2 impaired limb coordination 0.144186449945231 0.465046490178637 0.855115511551155 0.388888888888889 12.2 12 2 abnormal limb bone morphology 0.207387238778967 0.602306779290928 0.855115511551155 0.388888888888889 12.2 12 2 narrow eye opening 0.207387238778967 0.602306779290928 0.855115511551155 0.388888888888889 12.2 12 2 delayed kidney development 0.319779886470865 0.65014504911833 0.855115511551155 0.388888888888889 12.2 12 2 right pulmonary isomerism 0.319779886470865 0.65014504911833 0.855115511551155 0.388888888888889 12.2 12 2 abnormal mammary gland morphology 0.319779886470865 0.65014504911833 0.855115511551155 0.388888888888889 12.2 12 2 thick dermal layer 0.319779886470865 0.65014504911833 0.855115511551155 0.388888888888889 12.2 12 2 abnormal iron level 0.319779886470865 0.65014504911833 0.855115511551155 0.388888888888889 12.2 12 2 absent allantois 0.319779886470865 0.65014504911833 0.855115511551155 0.388888888888889 12.2 12 2 increased circulating renin level 0.319779886470865 0.65014504911833 0.855115511551155 0.388888888888889 12.2 12 2 abnormal body wall morphology 0.319779886470865 0.65014504911833 0.855115511551155 0.388888888888889 12.2 12 2 decreased activity of thyroid 0.319779886470865 0.65014504911833 0.855115511551155 0.388888888888889 12.2 12 2 jerky movement 0.319779886470865 0.65014504911833 0.855115511551155 0.388888888888889 12.2 12 2 abnormal pregnancy 0.319779886470865 0.65014504911833 0.855115511551155 0.388888888888889 12.2 12 2 atrioventricular block 0.319779886470865 0.65014504911833 0.855115511551155 0.388888888888889 12.2 12 2 abnormal cranium morphology 0.038153624802171 0.194681316298257 0.853292237539319 0.388059701492537 12.2 12 2 increased total body fat amount 0.038153624802171 0.194681316298257 0.853292237539319 0.388059701492537 12.2 12 2 decreased compact bone thickness 0.115892673519716 0.394098462584132 0.853292237539319 0.388059701492537 12.2 12 2 abnormal femur morphology 0.115892673519716 0.394098462584132 0.853292237539319 0.388059701492537 12.2 12 2 organ of Corti degeneration 0.162919112998179 0.51494446452728 0.852622463412522 0.387755102040816 12.2 12 2 increased fluid intake 0.162919112998179 0.51494446452728 0.852622463412522 0.387755102040816 12.2 12 2 increased circulating cholesterol level 0.0223468477399327 0.140196175922024 0.8495628134242 0.386363636363636 12.2 12 2 abnormal circadian rhythm 0.184714495907673 0.549942918695794 0.8495628134242 0.386363636363636 12.2 12 2 abnormal amino acid level 0.184714495907673 0.549942918695794 0.8495628134242 0.386363636363636 12.2 12 2 increased sensitivity to induced morbidity/mortality 0.0205765951666198 0.129863828233688 0.848476415964578 0.385869565217391 12.2 12 2 abnormal lipid level 0.0955193181348902 0.348996485632201 0.847756514033503 0.385542168674699 12.2 12 2 cyanosis 0.0189499299460895 0.1214895637652 0.847480551626591 0.385416666666667 12.2 12 2 abnormal iris morphology 0.210302447847884 0.610061036759898 0.845718637797846 0.384615384615385 12.2 12 2 increased vascular permeability 0.210302447847884 0.610061036759898 0.845718637797846 0.384615384615385 12.2 12 2 decreased kidney weight 0.165343469074438 0.521613036553791 0.845718637797846 0.384615384615385 12.2 12 2 abnormal stomach morphology 0.275148587864901 0.64186440054419 0.845718637797846 0.384615384615385 12.2 12 2 abnormal Schwann cell morphology 0.275148587864901 0.64186440054419 0.845718637797846 0.384615384615385 12.2 12 2 small seminal vesicle 0.275148587864901 0.64186440054419 0.845718637797846 0.384615384615385 12.2 12 2 absent myocardial trabeculae 0.383965044077132 0.716859934125368 0.845718637797846 0.384615384615385 12.2 12 2 abnormal renal/urinary system morphology 0.383965044077132 0.716859934125368 0.845718637797846 0.384615384615385 12.2 12 2 tight skin 0.383965044077132 0.716859934125368 0.845718637797846 0.384615384615385 12.2 12 2 abnormal digestion 0.383965044077132 0.716859934125368 0.845718637797846 0.384615384615385 12.2 12 2 abnormal soleus morphology 0.383965044077132 0.716859934125368 0.845718637797846 0.384615384615385 12.2 12 2 decreased endocochlear potential 0.383965044077132 0.716859934125368 0.845718637797846 0.384615384615385 12.2 12 2 increased circulating thyroxine level 0.383965044077132 0.716859934125368 0.845718637797846 0.384615384615385 12.2 12 2 abnormal gut flora balance 0.383965044077132 0.716859934125368 0.845718637797846 0.384615384615385 12.2 12 2 abnormal hair follicle inner root sheath morphology 0.383965044077132 0.716859934125368 0.845718637797846 0.384615384615385 12.2 12 2 reduced long term potentiation 0.0649736816594864 0.297920798392576 0.844208425944635 0.383928571428571 12.2 12 2 decreased anxiety-related response 0.0601779405798971 0.281112914915482 0.840218028771518 0.382113821138211 12.2 12 2 small ears 0.321675584712786 0.651870109527483 0.837664174580723 0.380952380952381 12.2 12 2 abnormal anxiety-related response 0.321675584712786 0.651870109527483 0.837664174580723 0.380952380952381 12.2 12 2 abnormal clavicle morphology 0.321675584712786 0.651870109527483 0.837664174580723 0.380952380952381 12.2 12 2 decreased liver weight 0.135542670913745 0.455317209855422 0.836189413709983 0.380281690140845 12.2 12 2 decreased respiratory quotient 0.189289650628426 0.560211785768246 0.835570014144271 0.38 12.2 12 2 abnormal circulating glucose level 0.277355946997476 0.64186440054419 0.834053553138565 0.379310344827586 12.2 12 2 short sternum 0.277355946997476 0.64186440054419 0.834053553138565 0.379310344827586 12.2 12 2 increased brown adipose tissue amount 0.242833023640378 0.637180534077468 0.832004281509232 0.378378378378378 12.2 12 2 abnormal breathing pattern 0.242833023640378 0.637180534077468 0.832004281509232 0.378378378378378 12.2 12 2 impaired skeletal muscle contractility 0.242833023640378 0.637180534077468 0.832004281509232 0.378378378378378 12.2 12 2 abnormal pancreatic islet morphology 0.191086615578732 0.56519376486575 0.829761682367698 0.377358490566038 12.2 12 2 abnormal blood homeostasis 0.0839772888474564 0.348996485632201 0.829397751805256 0.37719298245614 12.2 12 2 obese 0.13832582538103 0.458563578258382 0.828145263505942 0.376623376623377 12.2 12 2 abnormal urine homeostasis 0.114106730592185 0.393503770042863 0.8245756718529 0.375 12.2 12 2 short mandible 0.192615214344407 0.56668284527701 0.8245756718529 0.375 12.2 12 2 abnormal eye development 0.192615214344407 0.56668284527701 0.8245756718529 0.375 12.2 12 2 abnormal hair shaft morphology 0.216300639492867 0.611663378108013 0.8245756718529 0.375 12.2 12 2 abnormal vertebral body morphology 0.278865178079816 0.64186440054419 0.8245756718529 0.375 12.2 12 2 increased stereotypic behavior 0.322549208720101 0.651870109527483 0.8245756718529 0.375 12.2 12 2 prolonged QT interval 0.322549208720101 0.651870109527483 0.8245756718529 0.375 12.2 12 2 abnormal retinal ganglion layer morphology 0.322549208720101 0.651870109527483 0.8245756718529 0.375 12.2 12 2 absent mandible 0.382339099160709 0.716859934125368 0.8245756718529 0.375 12.2 12 2 delayed hair appearance 0.382339099160709 0.716859934125368 0.8245756718529 0.375 12.2 12 2 disorganized retinal layers 0.382339099160709 0.716859934125368 0.8245756718529 0.375 12.2 12 2 impaired muscle relaxation 0.382339099160709 0.716859934125368 0.8245756718529 0.375 12.2 12 2 abnormal pulmonary elastic fiber morphology 0.382339099160709 0.716859934125368 0.8245756718529 0.375 12.2 12 2 abnormal molar crown morphology 0.382339099160709 0.716859934125368 0.8245756718529 0.375 12.2 12 2 increased heart left ventricle size 0.382339099160709 0.716859934125368 0.8245756718529 0.375 12.2 12 2 abnormal gluconeogenesis 0.217616920452499 0.611663378108013 0.819186288376737 0.372549019607843 12.2 12 2 abnormal response to novel object 0.217616920452499 0.611663378108013 0.819186288376737 0.372549019607843 12.2 12 2 cleft secondary palate 0.127935392791002 0.430926593862718 0.818727617442595 0.372340425531915 12.2 12 2 impaired adaptive thermogenesis 0.279840493383648 0.64186440054419 0.816722570216205 0.371428571428571 12.2 12 2 abnormal chondrocyte morphology 0.218674948304321 0.614290156868435 0.814395725286814 0.37037037037037 12.2 12 2 abnormal trigeminal ganglion morphology 0.322724840154008 0.651870109527483 0.814395725286814 0.37037037037037 12.2 12 2 abnormal type II pneumocyte morphology 0.322724840154008 0.651870109527483 0.814395725286814 0.37037037037037 12.2 12 2 abnormal palate morphology 0.322724840154008 0.651870109527483 0.814395725286814 0.37037037037037 12.2 12 2 hyporesponsive to tactile stimuli 0.280399746809615 0.64186440054419 0.810109431995831 0.368421052631579 12.2 12 2 stereotypic behavior 0.380067943116126 0.716859934125368 0.810109431995831 0.368421052631579 12.2 12 2 abnormal long term depression 0.380067943116126 0.716859934125368 0.810109431995831 0.368421052631579 12.2 12 2 abnormal neurotransmitter level 0.380067943116126 0.716859934125368 0.810109431995831 0.368421052631579 12.2 12 2 abnormal response to novelty 0.380067943116126 0.716859934125368 0.810109431995831 0.368421052631579 12.2 12 2 maternal imprinting 0.380067943116126 0.716859934125368 0.810109431995831 0.368421052631579 12.2 12 2 abnormal optic vesicle formation 0.380067943116126 0.716859934125368 0.810109431995831 0.368421052631579 12.2 12 2 abnormal behavioral response to xenobiotic 0.380067943116126 0.716859934125368 0.810109431995831 0.368421052631579 12.2 12 2 thin interventricular septum 0.380067943116126 0.716859934125368 0.810109431995831 0.368421052631579 12.2 12 2 right-sided stomach 0.380067943116126 0.716859934125368 0.810109431995831 0.368421052631579 12.2 12 2 abnormal incisor morphology 0.220155735806719 0.616413867417968 0.806251768033946 0.366666666666667 12.2 12 2 abnormal response to new environment 0.322407242286106 0.651870109527483 0.806251768033946 0.366666666666667 12.2 12 2 emphysema 0.322407242286106 0.651870109527483 0.806251768033946 0.366666666666667 12.2 12 2 palatal shelves fail to meet at midline 0.280629726977973 0.64186440054419 0.80446407010039 0.365853658536585 12.2 12 2 increased susceptibility to injury 0.247713756094413 0.64186440054419 0.803432705907953 0.365384615384615 12.2 12 2 abnormal CNS synaptic transmission 0.161372679892231 0.510705523195833 0.7995885302816 0.363636363636364 12.2 12 2 embryonic lethality, incomplete penetrance 0.280595748231793 0.64186440054419 0.7995885302816 0.363636363636364 12.2 12 2 abnormal aorta morphology 0.321732008206611 0.651870109527483 0.7995885302816 0.363636363636364 12.2 12 2 belly spot 0.321732008206611 0.651870109527483 0.7995885302816 0.363636363636364 12.2 12 2 decreased systemic arterial blood pressure 0.321732008206611 0.651870109527483 0.7995885302816 0.363636363636364 12.2 12 2 increased body size 0.3774570558624 0.716859934125368 0.7995885302816 0.363636363636364 12.2 12 2 testis hypoplasia 0.3774570558624 0.716859934125368 0.7995885302816 0.363636363636364 12.2 12 2 increased coping response 0.3774570558624 0.716859934125368 0.7995885302816 0.363636363636364 12.2 12 2 abnormal retinal outer plexiform layer morphology 0.3774570558624 0.716859934125368 0.7995885302816 0.363636363636364 12.2 12 2 abnormal blood-brain barrier function 0.3774570558624 0.716859934125368 0.7995885302816 0.363636363636364 12.2 12 2 abnormal temporal bone morphology 0.3774570558624 0.716859934125368 0.7995885302816 0.363636363636364 12.2 12 2 increased circulating creatine kinase level 0.3774570558624 0.716859934125368 0.7995885302816 0.363636363636364 12.2 12 2 improved glucose tolerance 0.0781953291824947 0.336815378946243 0.796528880293277 0.362244897959184 12.2 12 2 abnormal innervation 0.280347883715124 0.64186440054419 0.795335399801378 0.361702127659574 12.2 12 2 abnormal digit morphology 0.221265092165848 0.616413867417968 0.794035832154644 0.361111111111111 12.2 12 2 renal hypoplasia 0.320792332942816 0.651670827435896 0.794035832154644 0.361111111111111 12.2 12 2 short radius 0.320792332942816 0.651670827435896 0.794035832154644 0.361111111111111 12.2 12 2 abnormal tooth morphology 0.247711923442167 0.64186440054419 0.790218352192362 0.359375 12.2 12 2 abnormal lens fiber morphology 0.319654234228185 0.65014504911833 0.789337395277989 0.358974358974359 12.2 12 2 abnormal cartilage morphology 0.318365657623344 0.65014504911833 0.785310163669428 0.357142857142857 12.2 12 2 abnormal vibrissa morphology 0.318365657623344 0.65014504911833 0.785310163669428 0.357142857142857 12.2 12 2 abnormal stria vascularis morphology 0.371783244917296 0.716859934125368 0.785310163669428 0.357142857142857 12.2 12 2 absent corpus callosum 0.371783244917296 0.716859934125368 0.785310163669428 0.357142857142857 12.2 12 2 abnormal interparietal bone morphology 0.457118518068032 0.834204866778189 0.785310163669428 0.357142857142857 12.2 12 2 abnormal zigzag hair morphology 0.457118518068032 0.834204866778189 0.785310163669428 0.357142857142857 12.2 12 2 megacephaly 0.457118518068032 0.834204866778189 0.785310163669428 0.357142857142857 12.2 12 2 abnormal placing response 0.457118518068032 0.834204866778189 0.785310163669428 0.357142857142857 12.2 12 2 extended life span 0.457118518068032 0.834204866778189 0.785310163669428 0.357142857142857 12.2 12 2 abnormal fluid regulation 0.457118518068032 0.834204866778189 0.785310163669428 0.357142857142857 12.2 12 2 decreased coping response 0.457118518068032 0.834204866778189 0.785310163669428 0.357142857142857 12.2 12 2 abnormal voluntary movement 0.457118518068032 0.834204866778189 0.785310163669428 0.357142857142857 12.2 12 2 abnormal uterus development 0.457118518068032 0.834204866778189 0.785310163669428 0.357142857142857 12.2 12 2 abnormal imprinting 0.457118518068032 0.834204866778189 0.785310163669428 0.357142857142857 12.2 12 2 abnormal hair cuticle 0.457118518068032 0.834204866778189 0.785310163669428 0.357142857142857 12.2 12 2 dehydration 0.247006522958546 0.64186440054419 0.785310163669428 0.357142857142857 12.2 12 2 abnormal colon morphology 0.277886373093043 0.64186440054419 0.782648095318006 0.355932203389831 12.2 12 2 altered response to myocardial infarction 0.316962157023571 0.648390925654715 0.781819896275342 0.355555555555556 12.2 12 2 decreased neuronal precursor cell number 0.368862153784826 0.715460625004071 0.780243646484464 0.354838709677419 12.2 12 2 short maxilla 0.36593451366355 0.715460625004071 0.776071220567435 0.352941176470588 12.2 12 2 distended urinary bladder 0.448353453072384 0.82521584500004 0.776071220567435 0.352941176470588 12.2 12 2 abnormal vagus nerve morphology 0.448353453072384 0.82521584500004 0.776071220567435 0.352941176470588 12.2 12 2 abnormal cranial suture morphology 0.448353453072384 0.82521584500004 0.776071220567435 0.352941176470588 12.2 12 2 decreased vasoconstriction 0.448353453072384 0.82521584500004 0.776071220567435 0.352941176470588 12.2 12 2 abnormal duodenum morphology 0.448353453072384 0.82521584500004 0.776071220567435 0.352941176470588 12.2 12 2 abnormal testis development 0.448353453072384 0.82521584500004 0.776071220567435 0.352941176470588 12.2 12 2 decreased growth hormone level 0.448353453072384 0.82521584500004 0.776071220567435 0.352941176470588 12.2 12 2 decreased body fat mass 0.448353453072384 0.82521584500004 0.776071220567435 0.352941176470588 12.2 12 2 corneal opacity 0.27403387882578 0.64186440054419 0.774249457138873 0.352112676056338 12.2 12 2 abnormal lens morphology 0.194872396947797 0.572308249595803 0.773039692362093 0.3515625 12.2 12 2 abnormal intestine morphology 0.27294511321833 0.64186440054419 0.772575404258573 0.351351351351351 12.2 12 2 malocclusion 0.363020292148304 0.715460625004071 0.772575404258573 0.351351351351351 12.2 12 2 decreased width of hypertrophic chondrocyte zone 0.363020292148304 0.715460625004071 0.772575404258573 0.351351351351351 12.2 12 2 polyuria 0.271821253937526 0.64186440054419 0.771031797057257 0.350649350649351 12.2 12 2 abnormal skin pigmentation 0.360132057598178 0.715460625004071 0.76960396039604 0.35 12.2 12 2 waved hair 0.440638861833337 0.813424244015159 0.76960396039604 0.35 12.2 12 2 abnormal dopamine level 0.440638861833337 0.813424244015159 0.76960396039604 0.35 12.2 12 2 abnormal fibula morphology 0.440638861833337 0.813424244015159 0.76960396039604 0.35 12.2 12 2 abnormal trachea morphology 0.440638861833337 0.813424244015159 0.76960396039604 0.35 12.2 12 2 decreased paired-pulse facilitation 0.440638861833337 0.813424244015159 0.76960396039604 0.35 12.2 12 2 abnormal lens epithelium morphology 0.440638861833337 0.813424244015159 0.76960396039604 0.35 12.2 12 2 nuclear cataracts 0.440638861833337 0.813424244015159 0.76960396039604 0.35 12.2 12 2 decreased muscle cell glucose uptake 0.440638861833337 0.813424244015159 0.76960396039604 0.35 12.2 12 2 abnormal kidney development 0.308972100862603 0.64186440054419 0.76960396039604 0.35 12.2 12 2 abnormal intestinal mucosa morphology 0.357277703691699 0.715460625004071 0.767047136607348 0.348837209302326 12.2 12 2 abnormal inner ear morphology 0.354462097728455 0.714236102146239 0.764823811573704 0.347826086956522 12.2 12 2 delayed wound healing 0.354462097728455 0.714236102146239 0.764823811573704 0.347826086956522 12.2 12 2 abnormal blood vessel physiology 0.433697037914825 0.802993213109882 0.764823811573704 0.347826086956522 12.2 12 2 abnormal cranial nerve morphology 0.433697037914825 0.802993213109882 0.764823811573704 0.347826086956522 12.2 12 2 abnormal hepatocyte physiology 0.433697037914825 0.802993213109882 0.764823811573704 0.347826086956522 12.2 12 2 abnormal hair growth 0.348957277748037 0.703714007619167 0.761146774018061 0.346153846153846 12.2 12 2 abnormal brain wave pattern 0.348957277748037 0.703714007619167 0.761146774018061 0.346153846153846 12.2 12 2 abnormal nasal bone morphology 0.427351287005724 0.792423649964025 0.761146774018061 0.346153846153846 12.2 12 2 no spontaneous movement 0.427351287005724 0.792423649964025 0.761146774018061 0.346153846153846 12.2 12 2 increased anxiety-related response 0.227526638665934 0.616413867417968 0.759321481994037 0.345323741007194 12.2 12 2 abnormal spinal nerve morphology 0.421481822769833 0.782414950850717 0.758230502853241 0.344827586206897 12.2 12 2 decreased retinal photoreceptor cell number 0.421481822769833 0.782414950850717 0.758230502853241 0.344827586206897 12.2 12 2 deafness 0.286691612751469 0.64186440054419 0.755166945265955 0.343434343434343 12.2 12 2 decreased triglyceride level 0.41085313294002 0.763824490424738 0.753897757122651 0.342857142857143 12.2 12 2 increased grooming behavior 0.405982975724422 0.755334818335453 0.752244472567558 0.342105263157895 12.2 12 2 decreased threshold for auditory brainstem response 0.405982975724422 0.755334818335453 0.752244472567558 0.342105263157895 12.2 12 2 seizures 0.278466695938914 0.64186440054419 0.752244472567557 0.342105263157895 12.2 12 2 abnormal excitatory postsynaptic potential 0.323972187979425 0.654124040258782 0.750833132093697 0.341463414634146 12.2 12 2 abnormal hindlimb morphology 0.388656912997021 0.724725690464835 0.747615275813296 0.34 12.2 12 2 impaired righting response 0.340648239540319 0.687515209619913 0.740671480681903 0.336842105263158 12.2 12 2 wrinkled skin 0.479664510431581 0.834204866778189 0.732956152758133 0.333333333333333 12.2 12 2 abnormal brain commissure morphology 0.479664510431581 0.834204866778189 0.732956152758133 0.333333333333333 12.2 12 2 abnormal limb morphology 0.390849904738493 0.728541879383291 0.732956152758133 0.333333333333333 12.2 12 2 impaired swimming 0.402808584312335 0.750551575638153 0.732956152758133 0.333333333333333 12.2 12 2 abnormal long bone epiphyseal plate morphology 0.411524166399969 0.764500645197852 0.732956152758133 0.333333333333333 12.2 12 2 abnormal eye physiology 0.411524166399969 0.764500645197852 0.732956152758133 0.333333333333333 12.2 12 2 increased kidney weight 0.426029647830794 0.790562289428646 0.732956152758133 0.333333333333333 12.2 12 2 abnormal cardiovascular system morphology 0.431336609910306 0.799515512035683 0.732956152758133 0.333333333333333 12.2 12 2 abnormal systemic arterial blood pressure 0.455883532938622 0.834204866778189 0.732956152758133 0.333333333333333 12.2 12 2 abnormal heart shape 0.512640236373142 0.834204866778189 0.732956152758133 0.333333333333333 12.2 12 2 interdigital webbing 0.527519298670187 0.834204866778189 0.732956152758133 0.333333333333333 12.2 12 2 absent vibrissae 0.463139136056443 0.834204866778189 0.732956152758133 0.333333333333333 12.2 12 2 delayed eyelid opening 0.471019113011696 0.834204866778189 0.732956152758133 0.333333333333333 12.2 12 2 no suckling reflex 0.527519298670187 0.834204866778189 0.732956152758133 0.333333333333333 12.2 12 2 reduced long term depression 0.455883532938622 0.834204866778189 0.732956152758133 0.333333333333333 12.2 12 2 abnormal respiratory system morphology 0.527519298670187 0.834204866778189 0.732956152758133 0.333333333333333 12.2 12 2 enhanced paired-pulse facilitation 0.471019113011696 0.834204866778189 0.732956152758133 0.333333333333333 12.2 12 2 increased vasoconstriction 0.500120500393612 0.834204866778189 0.732956152758133 0.333333333333333 12.2 12 2 increased alcohol consumption 0.527519298670187 0.834204866778189 0.732956152758133 0.333333333333333 12.2 12 2 dilated ureter 0.527519298670187 0.834204866778189 0.732956152758133 0.333333333333333 12.2 12 2 single kidney 0.463139136056443 0.834204866778189 0.732956152758133 0.333333333333333 12.2 12 2 absent ureter 0.512640236373142 0.834204866778189 0.732956152758133 0.333333333333333 12.2 12 2 dry skin 0.500120500393612 0.834204866778189 0.732956152758133 0.333333333333333 12.2 12 2 decreased aggression towards males 0.527519298670187 0.834204866778189 0.732956152758133 0.333333333333333 12.2 12 2 abnormal embryonic/fetal subventricular zone morphology 0.500120500393612 0.834204866778189 0.732956152758133 0.333333333333333 12.2 12 2 head tilt 0.455883532938622 0.834204866778189 0.732956152758133 0.333333333333333 12.2 12 2 cardiovascular system phenotype 0.463139136056443 0.834204866778189 0.732956152758133 0.333333333333333 12.2 12 2 abnormal neurotransmitter secretion 0.527519298670187 0.834204866778189 0.732956152758133 0.333333333333333 12.2 12 2 abnormal secondary palate development 0.527519298670187 0.834204866778189 0.732956152758133 0.333333333333333 12.2 12 2 abnormal aorta wall morphology 0.527519298670187 0.834204866778189 0.732956152758133 0.333333333333333 12.2 12 2 decreased fluid intake 0.512640236373142 0.834204866778189 0.732956152758133 0.333333333333333 12.2 12 2 increased liver weight 0.404614147508576 0.753351565814059 0.7246271055677 0.329545454545455 12.2 12 2 short femur 0.404614147508576 0.753351565814059 0.7246271055677 0.329545454545455 12.2 12 2 circling 0.408599378821703 0.7599184708927 0.724333139196273 0.329411764705882 12.2 12 2 decreased body temperature 0.463464799013848 0.834204866778189 0.718860842128169 0.326923076923077 12.2 12 2 abnormal blood circulation 0.484161362211314 0.834204866778189 0.715910660833525 0.325581395348837 12.2 12 2 impaired synaptic plasticity 0.509628303287826 0.834204866778189 0.711398618853482 0.323529411764706 12.2 12 2 abnormal retinal photoreceptor layer morphology 0.51966528407211 0.834204866778189 0.709312405894967 0.32258064516129 12.2 12 2 syndactyly 0.486696076899509 0.834204866778189 0.708110181478196 0.322033898305085 12.2 12 2 abnormal nervous system electrophysiology 0.471559520271254 0.834204866778189 0.706779147302485 0.321428571428571 12.2 12 2 myoclonus 0.530766162517295 0.838273542388427 0.706779147302485 0.321428571428571 12.2 12 2 increased circulating luteinizing hormone level 0.530766162517295 0.838273542388427 0.706779147302485 0.321428571428571 12.2 12 2 abnormal hormone level 0.530766162517295 0.838273542388427 0.706779147302485 0.321428571428571 12.2 12 2 increased triglyceride level 0.530766162517295 0.838273542388427 0.706779147302485 0.321428571428571 12.2 12 2 abnormal excitatory postsynaptic currents 0.48256565553201 0.834204866778189 0.704765531498205 0.320512820512821 12.2 12 2 abnormal nest building behavior 0.543202818492918 0.85682752758474 0.703637906647808 0.32 12.2 12 2 diaphragmatic hernia 0.543202818492918 0.85682752758474 0.703637906647808 0.32 12.2 12 2 intracerebral hemorrhage 0.557363441174844 0.874175006256257 0.6996399639964 0.318181818181818 12.2 12 2 decreased cardiac output 0.557363441174844 0.874175006256257 0.6996399639964 0.318181818181818 12.2 12 2 abnormal basement membrane morphology 0.557363441174844 0.874175006256257 0.6996399639964 0.318181818181818 12.2 12 2 abnormal response/metabolism to endogenous compounds 0.506793677937554 0.834204866778189 0.697202194087005 0.317073170731707 12.2 12 2 short humerus 0.534094557044049 0.843262590064787 0.697202194087005 0.317073170731707 12.2 12 2 impaired branching involved in ureteric bud morphogenesis 0.544061694422691 0.857115796802099 0.694379513139284 0.315789473684211 12.2 12 2 abnormal triglyceride level 0.573827448645611 0.890452762636281 0.694379513139284 0.315789473684211 12.2 12 2 irregular coat pigmentation 0.573827448645611 0.890452762636281 0.694379513139284 0.315789473684211 12.2 12 2 flaky skin 0.573827448645611 0.890452762636281 0.694379513139284 0.315789473684211 12.2 12 2 decreased grooming behavior 0.573827448645611 0.890452762636281 0.694379513139284 0.315789473684211 12.2 12 2 abnormal ear morphology 0.573827448645611 0.890452762636281 0.694379513139284 0.315789473684211 12.2 12 2 increased circulating VLDL cholesterol level 0.573827448645611 0.890452762636281 0.694379513139284 0.315789473684211 12.2 12 2 eyelids fail to open 0.573827448645611 0.890452762636281 0.694379513139284 0.315789473684211 12.2 12 2 abnormal long bone epiphyseal plate proliferative zone 0.537235292757344 0.84795227838445 0.692236366493792 0.314814814814815 12.2 12 2 abnormal mouth morphology 0.593510298447223 0.917561757232733 0.68714639321075 0.3125 12.2 12 2 white spotting 0.593510298447223 0.917561757232733 0.68714639321075 0.3125 12.2 12 2 decreased aggression towards mice 0.593510298447223 0.917561757232733 0.68714639321075 0.3125 12.2 12 2 bowed radius 0.593510298447223 0.917561757232733 0.68714639321075 0.3125 12.2 12 2 abnormal epididymis epithelium morphology 0.593510298447223 0.917561757232733 0.68714639321075 0.3125 12.2 12 2 sepsis 0.593510298447223 0.917561757232733 0.68714639321075 0.3125 12.2 12 2 decreased skeletal muscle weight 0.593510298447223 0.917561757232733 0.68714639321075 0.3125 12.2 12 2 decreased adipocyte glucose uptake 0.593510298447223 0.917561757232733 0.68714639321075 0.3125 12.2 12 2 abnormal middle ear morphology 0.579944115403653 0.899103139337231 0.682407452567917 0.310344827586207 12.2 12 2 absent long term depression 0.579944115403653 0.899103139337231 0.682407452567917 0.310344827586207 12.2 12 2 increased retinal apoptosis 0.579944115403653 0.899103139337231 0.682407452567917 0.310344827586207 12.2 12 2 thick skin 0.594692388042783 0.918818208233803 0.676574910238277 0.307692307692308 12.2 12 2 abnormal ocular fundus morphology 0.594692388042783 0.918818208233803 0.676574910238277 0.307692307692308 12.2 12 2 absent kidney 0.592331045526629 0.917561757232733 0.673122997430939 0.306122448979592 12.2 12 2 abnormal pulmonary artery morphology 0.611467492601102 0.927737351537202 0.669220835126991 0.304347826086957 12.2 12 2 hypotension 0.611467492601102 0.927737351537202 0.669220835126991 0.304347826086957 12.2 12 2 abnormal corneal stroma morphology 0.611467492601102 0.927737351537202 0.669220835126991 0.304347826086957 12.2 12 2 abnormal middle ear ossicle morphology 0.611847429273886 0.927747930703318 0.666323775234666 0.303030303030303 12.2 12 2 head tossing 0.611847429273886 0.927747930703318 0.666323775234666 0.303030303030303 12.2 12 2 increased susceptibility to pharmacologically induced seizures 0.625706206673369 0.943871551910252 0.664241513437058 0.302083333333333 12.2 12 2 head bobbing 0.62663411596703 0.944412216581634 0.65966053748232 0.3 12.2 12 2 perinatal lethality 0.62663411596703 0.944412216581634 0.65966053748232 0.3 12.2 12 2 abnormal pericardium morphology 0.630908271565157 0.949703071418051 0.65966053748232 0.3 12.2 12 2 abnormal hearing physiology 0.630908271565157 0.949703071418051 0.65966053748232 0.3 12.2 12 2 decreased circulating VLDL cholesterol level 0.630908271565157 0.949703071418051 0.65966053748232 0.3 12.2 12 2 abnormal lactation 0.62662625928592 0.944412216581634 0.65966053748232 0.3 12.2 12 2 abnormal action potential 0.633939417650908 0.953977193833414 0.65966053748232 0.3 12.2 12 2 abnormal axon extension 0.628382259168688 0.946760066433744 0.65966053748232 0.3 12.2 12 2 increased white adipose tissue amount 0.639933268043473 0.955135793002645 0.653717649757254 0.297297297297297 12.2 12 2 abnormal pancreatic beta cell physiology 0.639933268043473 0.955135793002645 0.653717649757254 0.297297297297297 12.2 12 2 abnormal mandible morphology 0.651590974894319 0.955135793002645 0.651516580229452 0.296296296296296 12.2 12 2 polyphagia 0.651590974894319 0.955135793002645 0.651516580229452 0.296296296296296 12.2 12 2 enlarged sebaceous gland 0.653992317353406 0.955135793002645 0.646726017139529 0.294117647058824 12.2 12 2 abnormal retinal photoreceptor morphology 0.654438731768078 0.955135793002645 0.646726017139529 0.294117647058824 12.2 12 2 nephrocalcinosis 0.653992317353406 0.955135793002645 0.646726017139529 0.294117647058824 12.2 12 2 decreased pancreatic beta cell number 0.654438731768078 0.955135793002645 0.646726017139529 0.294117647058824 12.2 12 2 coloboma 0.653992317353406 0.955135793002645 0.646726017139529 0.294117647058824 12.2 12 2 increased susceptibility to weight gain 0.654438731768078 0.955135793002645 0.646726017139529 0.294117647058824 12.2 12 2 short ulna 0.664926347245504 0.955135793002645 0.643571256080312 0.292682926829268 12.2 12 2 abnormal cholesterol homeostasis 0.664926347245504 0.955135793002645 0.643571256080312 0.292682926829268 12.2 12 2 abnormal digestive system morphology 0.661783714990655 0.955135793002645 0.641336633663366 0.291666666666667 12.2 12 2 apnea 0.661783714990655 0.955135793002645 0.641336633663366 0.291666666666667 12.2 12 2 decreased ovulation rate 0.661783714990655 0.955135793002645 0.641336633663366 0.291666666666667 12.2 12 2 abnormal cranial ganglia morphology 0.670383021873388 0.955135793002645 0.638381165305471 0.290322580645161 12.2 12 2 abnormal retinal outer nuclear layer morphology 0.678992057296384 0.960200535829877 0.63651455371101 0.289473684210526 12.2 12 2 increased percent body fat/body weight 0.695408299786012 0.97084708688313 0.634288978348384 0.288461538461538 12.2 12 2 hypoalgesia 0.683223380033776 0.962082172563837 0.628248130935543 0.285714285714286 12.2 12 2 decreased vocalization 0.683223380033776 0.962082172563837 0.628248130935543 0.285714285714286 12.2 12 2 abnormal long bone hypertrophic chondrocyte zone 0.707639785223046 0.984931120505989 0.628248130935543 0.285714285714286 12.2 12 2 abnormal diaphragm morphology 0.710921648212811 0.987942793256629 0.618431753889675 0.28125 12.2 12 2 abnormal serotonin level 0.710921648212811 0.987942793256629 0.618431753889675 0.28125 12.2 12 2 increased liver glycogen level 0.707898508073109 0.984931120505989 0.615683168316832 0.28 12.2 12 2 abnormal stomach mucosa morphology 0.707898508073109 0.984931120505989 0.615683168316832 0.28 12.2 12 2 abnormal mitral valve morphology 0.708358502345815 0.984931120505989 0.610796793965111 0.277777777777778 12.2 12 2 abnormal stomach glandular epithelium morphology 0.708358502345815 0.984931120505989 0.610796793965111 0.277777777777778 12.2 12 2 abnormal retinal rod cell morphology 0.708358502345815 0.984931120505989 0.610796793965111 0.277777777777778 12.2 12 2 decreased heart rate variability 0.708358502345815 0.984931120505989 0.610796793965111 0.277777777777778 12.2 12 2 abnormal eye anterior chamber morphology 0.708358502345815 0.984931120505989 0.610796793965111 0.277777777777778 12.2 12 2 abnormal food intake 0.785785771583141 1 0.605485517495849 0.27536231884058 12.2 12 2 increased susceptibility to weight loss 0.749108532112001 1 0.60468882602546 0.275 12.2 12 2 hypertension 0.76533724113812 1 0.5996913977112 0.272727272727273 12.2 12 2 abnormal tracheal cartilage morphology 0.730420857105875 1 0.5996913977112 0.272727272727273 12.2 12 2 abnormal cochlear sensory epithelium morphology 0.730420857105875 1 0.5996913977112 0.272727272727273 12.2 12 2 abnormal circulating lipid level 0.730420857105875 1 0.5996913977112 0.272727272727273 12.2 12 2 failure of palatal shelf elevation 0.730420857105875 1 0.5996913977112 0.272727272727273 12.2 12 2 abnormal kidney cortex morphology 0.749606025979018 1 0.592003046458492 0.269230769230769 12.2 12 2 abnormal ureter morphology 0.749606025979018 1 0.592003046458492 0.269230769230769 12.2 12 2 abnormal autopod morphology 0.793692501221672 1 0.586364922206506 0.266666666666667 12.2 12 2 abnormal estrous cycle 0.766580181258141 1 0.586364922206506 0.266666666666667 12.2 12 2 abnormal pain threshold 0.766580181258141 1 0.586364922206506 0.266666666666667 12.2 12 2 abnormal synaptic transmission 0.766580181258141 1 0.586364922206506 0.266666666666667 12.2 12 2 decreased urine osmolality 0.806214919840575 1 0.583373264440147 0.26530612244898 12.2 12 2 abnormal inhibitory postsynaptic currents 0.837365039091372 1 0.582053415425576 0.264705882352941 12.2 12 2 abnormal bone remodeling 0.781783349791765 1 0.582053415425576 0.264705882352941 12.2 12 2 abnormal innervation pattern to muscle 0.772404397519325 1 0.573617858680278 0.260869565217391 12.2 12 2 increased susceptibility to age related obesity 0.772404397519325 1 0.573617858680278 0.260869565217391 12.2 12 2 abnormal chondrocyte physiology 0.772404397519325 1 0.573617858680278 0.260869565217391 12.2 12 2 abnormal basicranium morphology 0.772404397519325 1 0.573617858680278 0.260869565217391 12.2 12 2 abnormal cochlea morphology 0.839744096352036 1 0.57007700770077 0.259259259259259 12.2 12 2 decreased susceptibility to pharmacologically induced seizures 0.786874322556101 1 0.57007700770077 0.259259259259259 12.2 12 2 abnormal intestine physiology 0.800040062783273 1 0.567449924715974 0.258064516129032 12.2 12 2 abnormal eye electrophysiology 0.927088304389869 1 0.563346464516582 0.256198347107438 12.2 12 2 abnormal axon guidance 0.833348111321531 1 0.562501233512055 0.255813953488372 12.2 12 2 increased systemic arterial blood pressure 0.842788545810195 1 0.561413223389208 0.25531914893617 12.2 12 2 decreased food intake 0.898557647447303 1 0.55667555905681 0.253164556962025 12.2 12 2 abnormal malleus morphology 0.809277958362215 1 0.5497171145686 0.25 12.2 12 2 abnormal jaw morphology 0.819809501723012 1 0.5497171145686 0.25 12.2 12 2 increased dopamine level 0.829746200973427 1 0.5497171145686 0.25 12.2 12 2 abnormal sensory capabilities/reflexes/nociception 0.809277958362215 1 0.5497171145686 0.25 12.2 12 2 abnormal long term potentiation 0.829746200973427 1 0.5497171145686 0.25 12.2 12 2 abnormal male reproductive system physiology 0.798237652463274 1 0.5497171145686 0.25 12.2 12 2 abnormal heart right ventricle morphology 0.798237652463274 1 0.5497171145686 0.25 12.2 12 2 abnormal osteoblast morphology 0.809277958362215 1 0.5497171145686 0.25 12.2 12 2 abnormal incus morphology 0.798237652463274 1 0.5497171145686 0.25 12.2 12 2 decreased fatty acid level 0.809277958362215 1 0.5497171145686 0.25 12.2 12 2 abnormal heart electrocardiography waveform feature 0.798237652463274 1 0.5497171145686 0.25 12.2 12 2 abnormal inner ear vestibule morphology 0.841292521611406 1 0.527728429985856 0.24 12.2 12 2 abnormal feces composition 0.841292521611406 1 0.527728429985856 0.24 12.2 12 2 abnormal energy expenditure 0.841292521611406 1 0.527728429985856 0.24 12.2 12 2 impaired conditioned place preference behavior 0.841292521611406 1 0.527728429985856 0.24 12.2 12 2 abnormal stapes morphology 0.834179612597492 1 0.523540109112952 0.238095238095238 12.2 12 2 abnormal enterocyte morphology 0.864696893624438 1 0.499742831426 0.227272727272727 12.2 12 2 abnormal photoreceptor outer segment morphology 0.920498362718481 1 0.499742831426 0.227272727272727 12.2 12 2 abnormal cartilage development 0.933159991152486 1 0.488637435172089 0.222222222222222 12.2 12 2 abnormal reflex 0.915366473632719 1 0.488637435172089 0.222222222222222 12.2 12 2 abnormal digestive system physiology 0.945411863439938 1 0.483751060820368 0.22 12.2 12 2 fragile skeleton 0.890333698098081 1 0.478014882233565 0.217391304347826 12.2 12 2 blistering 0.890333698098081 1 0.478014882233565 0.217391304347826 12.2 12 2 abnormal circulating cholesterol level 0.911949697275161 1 0.471186098201657 0.214285714285714 12.2 12 2 abnormal body temperature homeostasis 0.953505912381482 1 0.42558744353698 0.193548387096774 12.2 12 2 increased insulin secretion 0.969033938375155 1 0.416002140754616 0.189189189189189 12.2 12 2 aphagia 0.972342121417485 1 0.379115251426621 0.172413793103448 12.2 12 2 impaired behavioral response to xenobiotic 0.994014262375681 1 0.314124065467771 0.142857142857143 12.2 12 2 gastric polyps 0.000401683926193929 0.0081566429910808 3.77668262461278 1 12.5 12 5 decreased transitional stage T2 B cell number 6.24533894133232e-06 0.000233613242354348 3.39901436215151 0.9 12.5 12 5 heart hyperplasia 2.69489806743727e-05 0.000827599869475335 3.35705122187803 0.888888888888889 12.5 12 5 abnormal negative T cell selection 0.000482821268743556 0.00924206464554004 3.23715653538239 0.857142857142857 12.5 12 5 abnormal sperm annulus morphology 0.000482821268743556 0.00924206464554004 3.23715653538239 0.857142857142857 12.5 12 5 decreased DN4 thymocyte number 0.000482821268743556 0.00924206464554004 3.23715653538239 0.857142857142857 12.5 12 5 ductus venosus stenosis 0.000482821268743556 0.00924206464554004 3.23715653538239 0.857142857142857 12.5 12 5 epidermal necrosis 0.00198987436051887 0.027867003828864 3.14723552051065 0.833333333333333 12.5 12 5 abnormal lymph node cortex morphology 0.00198987436051887 0.027867003828864 3.14723552051065 0.833333333333333 12.5 12 5 decreased liver function 0.00198987436051887 0.027867003828864 3.14723552051065 0.833333333333333 12.5 12 5 decreased DN1 thymic pro-T cell number 0.00198987436051887 0.027867003828864 3.14723552051065 0.833333333333333 12.5 12 5 abnormal positive T cell selection 6.47629289056375e-06 0.000240444456198169 2.96739349076719 0.785714285714286 12.5 12 5 decreased transitional stage T1 B cell number 0.000422813115629165 0.0084477720893779 2.93741981914328 0.777777777777778 12.5 12 5 colon polyps 0.00158652870964791 0.0234213066186894 2.83251196845959 0.75 12.5 12 5 elevated level of mitotic sister chromatid exchange 0.00158652870964791 0.0234213066186894 2.83251196845959 0.75 12.5 12 5 abnormal kidney epithelium morphology 0.00158652870964791 0.0234213066186894 2.83251196845959 0.75 12.5 12 5 abnormal vertebral body development 0.00158652870964791 0.0234213066186894 2.83251196845959 0.75 12.5 12 5 craniofacial phenotype 0.00158652870964791 0.0234213066186894 2.83251196845959 0.75 12.5 12 5 increased brain apoptosis 0.00158652870964791 0.0234213066186894 2.83251196845959 0.75 12.5 12 5 spleen atrophy 3.35677719964187e-07 1.87640073800206e-05 2.83251196845959 0.75 12.5 12 5 abnormal thymocyte activation 3.35677719964187e-07 1.87640073800206e-05 2.83251196845959 0.75 12.5 12 5 abnormal dorsal-ventral polarity of the somites 0.000328069329399754 0.00706556239724578 2.74667827244566 0.727272727272727 12.5 12 5 decreased activated T cell number 0.00575750708995716 0.0635650253534768 2.69763044615199 0.714285714285714 12.5 12 5 increased colonic adenoma incidence 0.00575750708995716 0.0635650253534768 2.69763044615199 0.714285714285714 12.5 12 5 heart hemorrhage 0.00575750708995716 0.0635650253534768 2.69763044615199 0.714285714285714 12.5 12 5 increased tumor latency 0.00575750708995716 0.0635650253534768 2.69763044615199 0.714285714285714 12.5 12 5 increased DN3 thymocyte number 0.00575750708995716 0.0635650253534768 2.69763044615199 0.714285714285714 12.5 12 5 abnormal fetal cardiomyocyte proliferation 4.6553211397217e-08 3.262003192974e-06 2.65766555065344 0.703703703703704 12.5 12 5 absent inguinal lymph nodes 0.00115326210768197 0.0186888566310027 2.64367783722895 0.7 12.5 12 5 abnormal tail bud morphology 0.000239660782264218 0.00541960178074765 2.61462643242424 0.692307692307692 12.5 12 5 decreased fibroblast apoptosis 5.09223333904535e-05 0.00142325061021071 2.59646930442129 0.6875 12.5 12 5 abnormal T cell subpopulation ratio 1.87525147442238e-08 1.39244419182856e-06 2.51778841640852 0.666666666666667 12.5 12 5 abnormal Peyer's patch follicle morphology 3.62662403378036e-05 0.00107395562905103 2.51778841640852 0.666666666666667 12.5 12 5 abnormal hypoglossal nerve topology 3.62662403378036e-05 0.00107395562905103 2.51778841640852 0.666666666666667 12.5 12 5 decreased level of surface class I molecules 0.00391395989768539 0.0473770084938804 2.51778841640852 0.666666666666667 12.5 12 5 increased pheochromocytoma incidence 0.00391395989768539 0.0473770084938804 2.51778841640852 0.666666666666667 12.5 12 5 liver hyperplasia 0.00391395989768539 0.0473770084938804 2.51778841640852 0.666666666666667 12.5 12 5 increased thymocyte apoptosis 1.22123204274093e-06 5.8789351732893e-05 2.46936940840067 0.653846153846154 12.5 12 5 increased regulatory T cell number 0.000116865823570781 0.0028640762180524 2.44373581592592 0.647058823529412 12.5 12 5 abnormal ectoplacental cone morphology 0.000116865823570781 0.0028640762180524 2.44373581592592 0.647058823529412 12.5 12 5 increased hemangioma incidence 0.000545971702114463 0.0101351090224606 2.42786740153679 0.642857142857143 12.5 12 5 lysosomal protein accumulation 0.000545971702114463 0.0101351090224606 2.42786740153679 0.642857142857143 12.5 12 5 decreased response to antigen 0.000545971702114463 0.0101351090224606 2.42786740153679 0.642857142857143 12.5 12 5 abnormal thrombopoiesis 0.00259734946967586 0.0340047726622037 2.40334348838995 0.636363636363636 12.5 12 5 abnormal blastocyst morphology 7.96111586611121e-05 0.00210673145925017 2.38527323659755 0.631578947368421 12.5 12 5 abnormal cecum morphology 0.0127091377238059 0.117962612268534 2.36042664038299 0.625 12.5 12 5 preneoplasia 0.0127091377238059 0.117962612268534 2.36042664038299 0.625 12.5 12 5 abnormal hepatobiliary system morphology 0.0127091377238059 0.117962612268534 2.36042664038299 0.625 12.5 12 5 abnormal platelet shape 0.0127091377238059 0.117962612268534 2.36042664038299 0.625 12.5 12 5 lymph node inflammation 0.0127091377238059 0.117962612268534 2.36042664038299 0.625 12.5 12 5 abnormal extraembryonic tissue physiology 0.0127091377238059 0.117962612268534 2.36042664038299 0.625 12.5 12 5 accumulation of giant lysosomes in kidney/renal tubule cells 0.0127091377238059 0.117962612268534 2.36042664038299 0.625 12.5 12 5 decreased cranium length 0.0127091377238059 0.117962612268534 2.36042664038299 0.625 12.5 12 5 decreased vascular endothelial cell proliferation 0.0127091377238059 0.117962612268534 2.36042664038299 0.625 12.5 12 5 increased mortality induced by gamma-irradiation 1.81063416116036e-06 8.04277227836857e-05 2.34414783596656 0.620689655172414 12.5 12 5 abnormal CD8-positive, alpha-beta T cell physiology 1.81063416116036e-06 8.04277227836857e-05 2.34414783596656 0.620689655172414 12.5 12 5 short premaxilla 0.00170389951965379 0.0249320591478753 2.3241123843771 0.615384615384615 12.5 12 5 abnormal T cell proliferation 1.22896333270771e-06 5.8789351732893e-05 2.31474096347235 0.612903225806452 12.5 12 5 increased B cell derived lymphoma incidence 2.11255176324439e-09 1.9108990949347e-07 2.26600957476767 0.6 12.5 12 5 decreased thymocyte apoptosis 0.00111119709839253 0.018125264145911 2.26600957476767 0.6 12.5 12 5 enlarged testis 0.00805500658269049 0.0827968135307545 2.26600957476767 0.6 12.5 12 5 absent axillary lymph nodes 0.00805500658269049 0.0827968135307545 2.26600957476767 0.6 12.5 12 5 abnormal left subclavian artery morphology 0.00805500658269049 0.0827968135307545 2.26600957476767 0.6 12.5 12 5 lethality during fetal growth through weaning, complete penetrance 0.00805500658269049 0.0827968135307545 2.26600957476767 0.6 12.5 12 5 increased cellular sensitivity to gamma-irradiation 9.08763921610815e-09 7.29209759679646e-07 2.2499385848757 0.595744680851064 12.5 12 5 abnormal cytotoxic T cell physiology 5.81586437652244e-08 3.96355140728755e-06 2.24802537179332 0.595238095238095 12.5 12 5 abnormal B cell differentiation 1.65653417643629e-15 3.92440834655741e-13 2.24110837064935 0.593406593406593 12.5 12 5 increased adenoma incidence 0.000106076931271707 0.00265192328179268 2.2316760963621 0.590909090909091 12.5 12 5 decreased trophoblast giant cell number 1.05524425299371e-05 0.000369707053425614 2.21391740063508 0.586206896551724 12.5 12 5 interstitial pneumonia 0.0051096773888424 0.0583042316731443 2.20306486435746 0.583333333333333 12.5 12 5 altered tumor susceptibility 0.0051096773888424 0.0583042316731443 2.20306486435746 0.583333333333333 12.5 12 5 increased growth rate 0.0051096773888424 0.0583042316731443 2.20306486435746 0.583333333333333 12.5 12 5 abnormal vascular endothelial cell development 0.0051096773888424 0.0583042316731443 2.20306486435746 0.583333333333333 12.5 12 5 abnormal rostral-caudal body axis extension 0.0051096773888424 0.0583042316731443 2.20306486435746 0.583333333333333 12.5 12 5 increased fibrosarcoma incidence 0.0051096773888424 0.0583042316731443 2.20306486435746 0.583333333333333 12.5 12 5 abnormal vitelline vein connection 0.0051096773888424 0.0583042316731443 2.20306486435746 0.583333333333333 12.5 12 5 decreased double-positive T cell number 6.52256180607181e-16 1.70788131501091e-13 2.19047592227542 0.58 12.5 12 5 enlarged adrenal glands 0.000468900146673223 0.00918416625865861 2.18650046688109 0.578947368421053 12.5 12 5 increased double-negative T cell number 5.44295366426584e-10 5.64139468327553e-08 2.16694904690898 0.573770491803279 12.5 12 5 increased T cell proliferation 3.63219076183852e-16 1.00389716889704e-13 2.15306205702224 0.570093457943925 12.5 12 5 failure of chorioallantoic fusion 2.15606582519719e-08 1.57741580593471e-06 2.14752541399551 0.568627450980392 12.5 12 5 abnormal T cell activation 1.7028529736588e-11 2.22939303788224e-09 2.14352257072618 0.567567567567568 12.5 12 5 extramedullary hematopoiesis 9.98313051331228e-16 2.48330371518643e-13 2.13774488185629 0.566037735849057 12.5 12 5 abnormal spongiotrophoblast layer morphology 1.28153898486203e-05 0.000433718125829156 2.12438397634469 0.5625 12.5 12 5 increased intestinal adenocarcinoma incidence 0.00206903915211991 0.0287527088876998 2.12438397634469 0.5625 12.5 12 5 embryonic lethality between somite formation and embryo turning, incomplete penetrance 0.00206903915211991 0.0287527088876998 2.12438397634469 0.5625 12.5 12 5 thymus atrophy 8.97844318852573e-08 5.86817190380069e-06 2.12438397634469 0.5625 12.5 12 5 abnormal thymus medulla morphology 0.00132102666558352 0.0207322008242208 2.09815701367377 0.555555555555556 12.5 12 5 abnormal redox activity 0.00132102666558352 0.0207322008242208 2.09815701367377 0.555555555555556 12.5 12 5 absent inner cell mass 0.00132102666558352 0.0207322008242208 2.09815701367377 0.555555555555556 12.5 12 5 increased effector memory CD8-positive, alpha-beta T cell number 0.00132102666558352 0.0207322008242208 2.09815701367377 0.555555555555556 12.5 12 5 impaired leukocyte tethering or rolling 0.00132102666558352 0.0207322008242208 2.09815701367377 0.555555555555556 12.5 12 5 distorted hair follicle pattern 0.0237031100064566 0.179487020216319 2.09815701367377 0.555555555555556 12.5 12 5 thick tail 0.0237031100064566 0.179487020216319 2.09815701367377 0.555555555555556 12.5 12 5 multifocal hepatic necrosis 0.0237031100064566 0.179487020216319 2.09815701367377 0.555555555555556 12.5 12 5 abnormal posterior semicircular canal morphology 0.0237031100064566 0.179487020216319 2.09815701367377 0.555555555555556 12.5 12 5 premature neuronal precursor differentiation 0.0237031100064566 0.179487020216319 2.09815701367377 0.555555555555556 12.5 12 5 abnormal thymus physiology 0.0237031100064566 0.179487020216319 2.09815701367377 0.555555555555556 12.5 12 5 decreased cellular sensitivity to ionizing radiation 0.0237031100064566 0.179487020216319 2.09815701367377 0.555555555555556 12.5 12 5 increased neuronal precursor cell number 0.0237031100064566 0.179487020216319 2.09815701367377 0.555555555555556 12.5 12 5 absent cervical lymph nodes 0.0237031100064566 0.179487020216319 2.09815701367377 0.555555555555556 12.5 12 5 eye opacity 0.0237031100064566 0.179487020216319 2.09815701367377 0.555555555555556 12.5 12 5 abnormal ventricle myocardium morphology 0.0237031100064566 0.179487020216319 2.09815701367377 0.555555555555556 12.5 12 5 iris coloboma 0.0237031100064566 0.179487020216319 2.09815701367377 0.555555555555556 12.5 12 5 increased myeloid cell number 0.0237031100064566 0.179487020216319 2.09815701367377 0.555555555555556 12.5 12 5 increased endoplasmic reticulum stress 0.0237031100064566 0.179487020216319 2.09815701367377 0.555555555555556 12.5 12 5 abnormal embryonic erythropoiesis 5.38040763065861e-05 0.00149539262360484 2.08368696530361 0.551724137931034 12.5 12 5 thymus hypoplasia 1.39944873205981e-18 6.96225744199754e-16 2.07991217007661 0.550724637681159 12.5 12 5 small gonad 0.000845187957943683 0.0144000345574309 2.07717544353703 0.55 12.5 12 5 brain inflammation 0.000845187957943683 0.0144000345574309 2.07717544353703 0.55 12.5 12 5 increased mammary adenocarcinoma incidence 0.000845187957943683 0.0144000345574309 2.07717544353703 0.55 12.5 12 5 myeloid hyperplasia 2.26733620058819e-05 0.000723076769097837 2.06000870433425 0.545454545454545 12.5 12 5 abnormal chorion morphology 0.000541771368855809 0.0101351090224606 2.06000870433425 0.545454545454545 12.5 12 5 abnormal lysosome physiology 0.000541771368855809 0.0101351090224606 2.06000870433425 0.545454545454545 12.5 12 5 abnormal occipital bone morphology 0.000541771368855809 0.0101351090224606 2.06000870433425 0.545454545454545 12.5 12 5 abnormal sphenoid bone morphology 0.0146041951183081 0.128822465804225 2.06000870433425 0.545454545454545 12.5 12 5 abnormal large intestine morphology 0.0146041951183081 0.128822465804225 2.06000870433425 0.545454545454545 12.5 12 5 delayed hepatic development 0.0146041951183081 0.128822465804225 2.06000870433425 0.545454545454545 12.5 12 5 abnormal proximal-distal axis patterning 0.0146041951183081 0.128822465804225 2.06000870433425 0.545454545454545 12.5 12 5 abnormal coronal suture morphology 0.0146041951183081 0.128822465804225 2.06000870433425 0.545454545454545 12.5 12 5 hypolactation 0.0146041951183081 0.128822465804225 2.06000870433425 0.545454545454545 12.5 12 5 thin hypoglossal nerve 0.0146041951183081 0.128822465804225 2.06000870433425 0.545454545454545 12.5 12 5 abnormal lymphocyte physiology 6.52049988603692e-07 3.37911322219101e-05 2.05254490468086 0.543478260869565 12.5 12 5 ocular hypertelorism 0.000347874382274592 0.00733336886362753 2.04570308833193 0.541666666666667 12.5 12 5 abnormal tumor morphology 0.000347874382274592 0.00733336886362753 2.04570308833193 0.541666666666667 12.5 12 5 abnormal inner cell mass apoptosis 0.000347874382274592 0.00733336886362753 2.04570308833193 0.541666666666667 12.5 12 5 abnormal NK cell physiology 1.27181528035245e-08 9.58678942386882e-07 2.0431233870856 0.540983606557377 12.5 12 5 decreased B-1 B cell number 6.22211311115093e-06 0.000233613242354348 2.03359833632996 0.538461538461538 12.5 12 5 abnormal mast cell morphology 0.00908308490289576 0.0896852534878534 2.03359833632996 0.538461538461538 12.5 12 5 increased pituitary adenoma incidence 0.00908308490289576 0.0896852534878534 2.03359833632996 0.538461538461538 12.5 12 5 abnormal telomere length 0.00908308490289576 0.0896852534878534 2.03359833632996 0.538461538461538 12.5 12 5 absent hypoglossal nerve 0.00908308490289576 0.0896852534878534 2.03359833632996 0.538461538461538 12.5 12 5 abnormal definitive hematopoiesis 3.37852648743593e-12 4.94357919852758e-10 2.03047452936171 0.537634408602151 12.5 12 5 lymphoid hyperplasia 0.000144073918604972 0.00342951074191261 2.02322283461399 0.535714285714286 12.5 12 5 abnormal T cell differentiation 6.30277675708536e-13 1.20601209101922e-10 2.01921645276327 0.534653465346535 12.5 12 5 arrested T cell differentiation 9.29007167691302e-05 0.00239472054884157 2.01423073312682 0.533333333333333 12.5 12 5 abnormal trophectoderm morphology 0.00568963890835046 0.0635650253534768 2.01423073312682 0.533333333333333 12.5 12 5 abnormal spleen red pulp morphology 3.8755558915553e-05 0.00113417003296986 1.9994202130303 0.529411764705882 12.5 12 5 abnormal embryonic-extraembryonic boundary morphology 0.00358399342077035 0.0447999177596293 1.9994202130303 0.529411764705882 12.5 12 5 pancytopenia 0.00358399342077035 0.0447999177596293 1.9994202130303 0.529411764705882 12.5 12 5 enhanced behavioral response to cocaine 0.00358399342077035 0.0447999177596293 1.9994202130303 0.529411764705882 12.5 12 5 abnormal lysosome morphology 2.50685861330352e-05 0.00079437080262325 1.99324916299008 0.527777777777778 12.5 12 5 decreased tumor incidence 0.00226783390881718 0.0304931721523391 1.98772769716462 0.526315789473684 12.5 12 5 increased liver adenoma incidence 0.00226783390881718 0.0304931721523391 1.98772769716462 0.526315789473684 12.5 12 5 increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 0.00226783390881718 0.0304931721523391 1.98772769716462 0.526315789473684 12.5 12 5 embryonic lethality between implantation and somite formation, incomplete penetrance 0.00226783390881718 0.0304931721523391 1.98772769716462 0.526315789473684 12.5 12 5 abnormal hematopoietic system physiology 0.0014403628684908 0.0220486316022823 1.97826232717813 0.523809523809524 12.5 12 5 increased incidence of induced tumors 0.0014403628684908 0.0220486316022823 1.97826232717813 0.523809523809524 12.5 12 5 increased T cell number 8.75174869829835e-11 1.00661746512756e-08 1.97417500832032 0.522727272727273 12.5 12 5 abnormal myelopoiesis 4.42365091233728e-06 0.000173288687314 1.97417500832032 0.522727272727273 12.5 12 5 failure to gastrulate 2.87194685866979e-06 0.000119962323147254 1.97044310849363 0.521739130434783 12.5 12 5 decreased bone marrow cell number 4.32868905678978e-09 3.71297035474641e-07 1.96594437993542 0.520547945205479 12.5 12 5 decreased T cell proliferation 6.56619295417233e-17 2.33334356764338e-14 1.96489568983233 0.52027027027027 12.5 12 5 increased pre-B cell number 0.000586215018166316 0.0108015545013979 1.96387496479865 0.52 12.5 12 5 decreased B cell proliferation 1.20808953430883e-09 1.13400857229933e-07 1.96005047606486 0.518987341772152 12.5 12 5 abnormal apoptosis 5.12947585310311e-07 2.74399380313849e-05 1.95827987942885 0.518518518518518 12.5 12 5 decreased circulating fructosamine level 0.000375333989036842 0.00781291462534849 1.95827987942885 0.518518518518518 12.5 12 5 abnormal cell morphology 3.5676978279707e-13 7.09971867766169e-11 1.95459890221188 0.517543859649123 12.5 12 5 thrombocytosis 2.17366331017843e-07 1.30288855037804e-05 1.95345652997213 0.517241379310345 12.5 12 5 polychromatophilia 0.000240791606781812 0.00542053503954532 1.95345652997213 0.517241379310345 12.5 12 5 pale kidney 0.000154746632714128 0.00361438731339337 1.94925554818724 0.516129032258065 12.5 12 5 abnormal CD8-positive, alpha beta T cell morphology 0.000154746632714128 0.00361438731339337 1.94925554818724 0.516129032258065 12.5 12 5 abnormal embryo turning 8.36225029709109e-07 4.24098586752872e-05 1.92267479071196 0.509090909090909 12.5 12 5 abnormal CD4-positive, alpha-beta T cell physiology 2.70150514535797e-08 1.94782436205158e-06 1.91493766881775 0.507042253521127 12.5 12 5 spleen hyperplasia 1.14912225396048e-08 8.93263002102095e-07 1.91351919647048 0.506666666666667 12.5 12 5 pale yolk sac 2.08523603299523e-09 1.9108990949347e-07 1.91109241245466 0.506024096385542 12.5 12 5 abnormal erythropoiesis 1.93694899493366e-11 2.47085160251153e-09 1.90632551528074 0.504761904761905 12.5 12 5 abnormal cell cycle 2.32026897940266e-12 3.49798126440249e-10 1.90476167154384 0.504347826086956 12.5 12 5 increased fibroblast apoptosis 0.000249521010039211 0.00559174335560843 1.88834131230639 0.5 12.5 12 5 decreased mast cell number 0.00931023866458103 0.0902893515717166 1.88834131230639 0.5 12.5 12 5 blepharitis 0.00931023866458103 0.0902893515717166 1.88834131230639 0.5 12.5 12 5 abnormal pulmonary alveolus wall morphology 0.00931023866458103 0.0902893515717166 1.88834131230639 0.5 12.5 12 5 pale liver 2.8131603780738e-08 1.99935326870245e-06 1.88834131230639 0.5 12.5 12 5 kinked neural tube 3.17371534173278e-06 0.000130489535744798 1.88834131230639 0.5 12.5 12 5 decreased Peyer's patch number 0.000948712235480255 0.0157328112383809 1.88834131230639 0.5 12.5 12 5 abnormal extraembryonic tissue morphology 7.21823118173871e-11 8.75870734857319e-09 1.88834131230639 0.5 12.5 12 5 embryonic lethality between implantation and placentation, complete penetrance 1.16415327546543e-05 0.000402198787877812 1.88834131230639 0.5 12.5 12 5 abnormal brain vasculature morphology 0.000388682496794494 0.00799719768976466 1.88834131230639 0.5 12.5 12 5 subcutaneous edema 0.000606594059468712 0.0109198083487904 1.88834131230639 0.5 12.5 12 5 increased mammary gland tumor incidence 0.0023389543681258 0.0311130962070211 1.88834131230639 0.5 12.5 12 5 embryonic lethality before implantation, incomplete penetrance 0.0023389543681258 0.0311130962070211 1.88834131230639 0.5 12.5 12 5 impaired humoral immune response 0.0023389543681258 0.0311130962070211 1.88834131230639 0.5 12.5 12 5 abnormal antigen presentation 0.0149183665294186 0.129980513982237 1.88834131230639 0.5 12.5 12 5 increased lactate dehydrogenase level 0.0149183665294186 0.129980513982237 1.88834131230639 0.5 12.5 12 5 abnormal voluntary movement 0.0149183665294186 0.129980513982237 1.88834131230639 0.5 12.5 12 5 vascular smooth muscle hypoplasia 0.0149183665294186 0.129980513982237 1.88834131230639 0.5 12.5 12 5 increased B-1 B cell number 0.0149183665294186 0.129980513982237 1.88834131230639 0.5 12.5 12 5 abnormal viscerocranium morphology 0.0149183665294186 0.129980513982237 1.88834131230639 0.5 12.5 12 5 increased stomach tumor incidence 0.0149183665294186 0.129980513982237 1.88834131230639 0.5 12.5 12 5 abnormal thymus involution 0.0240987128477738 0.180287363034098 1.88834131230639 0.5 12.5 12 5 myocarditis 0.0240987128477738 0.180287363034098 1.88834131230639 0.5 12.5 12 5 increased papilloma incidence 0.0240987128477738 0.180287363034098 1.88834131230639 0.5 12.5 12 5 abnormal embryonic growth/weight/body size 0.0240987128477738 0.180287363034098 1.88834131230639 0.5 12.5 12 5 small intestinal inflammation 0.0240987128477738 0.180287363034098 1.88834131230639 0.5 12.5 12 5 increased osteosarcoma incidence 0.0240987128477738 0.180287363034098 1.88834131230639 0.5 12.5 12 5 persistent right dorsal aorta 0.0240987128477738 0.180287363034098 1.88834131230639 0.5 12.5 12 5 decreased tumor growth/size 2.06056695517425e-06 8.99238649297536e-05 1.88834131230639 0.5 12.5 12 5 abnormal vascular regression 0.00369047985969067 0.0456719833382117 1.88834131230639 0.5 12.5 12 5 increased skin tumor incidence 0.00369047985969067 0.0456719833382117 1.88834131230639 0.5 12.5 12 5 abnormal megakaryocyte differentiation 0.00584696017595718 0.0637908484109364 1.88834131230639 0.5 12.5 12 5 abnormal bile duct morphology 0.00584696017595718 0.0637908484109364 1.88834131230639 0.5 12.5 12 5 increased circulating glycerol level 0.00584696017595718 0.0637908484109364 1.88834131230639 0.5 12.5 12 5 small thoracic cage 0.00584696017595718 0.0637908484109364 1.88834131230639 0.5 12.5 12 5 retarded hair growth 0.0393512134302226 0.25126120331107 1.88834131230639 0.5 12.5 12 5 abnormal mammary gland physiology 0.0393512134302226 0.25126120331107 1.88834131230639 0.5 12.5 12 5 abnormal tibialis anterior morphology 0.0393512134302226 0.25126120331107 1.88834131230639 0.5 12.5 12 5 acrania 0.0393512134302226 0.25126120331107 1.88834131230639 0.5 12.5 12 5 aneurysm 0.0393512134302226 0.25126120331107 1.88834131230639 0.5 12.5 12 5 peritoneal inflammation 0.0393512134302226 0.25126120331107 1.88834131230639 0.5 12.5 12 5 absent CD4-positive, alpha beta T cells 0.0393512134302226 0.25126120331107 1.88834131230639 0.5 12.5 12 5 abnormal submandibular gland morphology 0.0393512134302226 0.25126120331107 1.88834131230639 0.5 12.5 12 5 abnormal plasma membrane morphology 0.0393512134302226 0.25126120331107 1.88834131230639 0.5 12.5 12 5 abnormal deltoid tuberosity morphology 0.0393512134302226 0.25126120331107 1.88834131230639 0.5 12.5 12 5 abnormal corneal endothelium morphology 0.0393512134302226 0.25126120331107 1.88834131230639 0.5 12.5 12 5 tachypnea 0.0393512134302226 0.25126120331107 1.88834131230639 0.5 12.5 12 5 increased platelet aggregation 0.0393512134302226 0.25126120331107 1.88834131230639 0.5 12.5 12 5 abnormal adaptive thermogenesis 0.0393512134302226 0.25126120331107 1.88834131230639 0.5 12.5 12 5 decreased macrophage cytokine production 0.0393512134302226 0.25126120331107 1.88834131230639 0.5 12.5 12 5 decreased macrophage apoptosis 0.0393512134302226 0.25126120331107 1.88834131230639 0.5 12.5 12 5 embryonic lethality before implantation, complete penetrance 1.07012105343571e-12 1.82081311670119e-10 1.87323458180794 0.496 12.5 12 5 decreased lymphocyte cell number 1.09797775881479e-12 1.82081311670119e-10 1.85883597930161 0.4921875 12.5 12 5 increased B cell proliferation 1.36921172036203e-06 6.42625312151048e-05 1.85633552735205 0.491525423728814 12.5 12 5 increased hepatocellular carcinoma incidence 2.10608826373947e-06 9.11112096704682e-05 1.85521251735365 0.491228070175439 12.5 12 5 abnormal trophoblast layer morphology 7.68940304821326e-06 0.000277208551919282 1.85131501206509 0.490196078431373 12.5 12 5 increased sarcoma incidence 1.18548577307799e-05 0.000404494602472036 1.84980373450422 0.489795918367347 12.5 12 5 abnormal cell nucleus morphology 1.82896168675118e-05 0.000602588370303782 1.84816383757647 0.48936170212766 12.5 12 5 abnormal vasculogenesis 4.36363655429848e-05 0.00123347112827471 1.84442639806671 0.488372093023256 12.5 12 5 embryonic lethality between somite formation and embryo turning, complete penetrance 2.48678188938967e-07 1.45549881173101e-05 1.83438870338335 0.485714285714286 12.5 12 5 abnormal embryonic epiblast morphology 0.000251354187686723 0.00560756539794372 1.83438870338335 0.485714285714286 12.5 12 5 abnormal embryo development 7.41986780180525e-13 1.36717934496226e-10 1.83280186194444 0.485294117647059 12.5 12 5 increased cardiomyocyte apoptosis 0.000390620944562085 0.00799728065512911 1.83111884829711 0.484848484848485 12.5 12 5 increased lung adenoma incidence 0.000607997369369839 0.0109198083487904 1.82742707642554 0.483870967741935 12.5 12 5 decreased thymus weight 0.000607997369369839 0.0109198083487904 1.82742707642554 0.483870967741935 12.5 12 5 decreased granulocyte number 0.000948009681976486 0.0157328112383809 1.82322609464065 0.482758620689655 12.5 12 5 decreased leukocyte cell number 1.13961892899453e-12 1.82890457153154e-10 1.81942374616382 0.481751824817518 12.5 12 5 liver hypoplasia 1.18705953690286e-05 0.000404494602472036 1.81571280029461 0.480769230769231 12.5 12 5 decreased B cell number 3.65509937773365e-18 1.65310176402045e-15 1.81500766911003 0.480582524271845 12.5 12 5 vertebral transformation 2.81763268225237e-05 0.00085473918257351 1.80966042429363 0.479166666666667 12.5 12 5 abnormal cell death 4.34528030336636e-05 0.00123347112827471 1.80623951611916 0.478260869565217 12.5 12 5 dilated heart 0.00364179541813197 0.0452948305130163 1.80623951611916 0.478260869565217 12.5 12 5 abnormal vertebral artery topology 0.00364179541813197 0.0452948305130163 1.80623951611916 0.478260869565217 12.5 12 5 abnormal spleen white pulp morphology 0.000103578428630523 0.00260253880018611 1.79842029743466 0.476190476190476 12.5 12 5 liver degeneration 0.00573604076078147 0.0635650253534768 1.79842029743466 0.476190476190476 12.5 12 5 abnormal tumor vascularization 0.00573604076078147 0.0635650253534768 1.79842029743466 0.476190476190476 12.5 12 5 absent segment of posterior cerebral artery 0.00573604076078147 0.0635650253534768 1.79842029743466 0.476190476190476 12.5 12 5 increased tumor incidence 3.333021218437e-11 4.14544514043102e-09 1.79696995848512 0.475806451612903 12.5 12 5 increased embryonic tissue cell apoptosis 1.61139177109164e-07 9.89712847059373e-06 1.79150329629068 0.474358974358974 12.5 12 5 impaired natural killer cell mediated cytotoxicity 7.62836264837381e-06 0.000277015358946421 1.78895492744816 0.473684210526316 12.5 12 5 abnormal optic vesicle formation 0.00906817381638319 0.0896852534878534 1.78895492744816 0.473684210526316 12.5 12 5 decreased circulating magnesium level 0.00906817381638319 0.0896852534878534 1.78895492744816 0.473684210526316 12.5 12 5 abnormal mesoderm development 1.80132822366951e-05 0.000597440527517055 1.78145406821358 0.471698113207547 12.5 12 5 decreased regulatory T cell number 0.000595218139460148 0.0108868023669641 1.77726241158249 0.470588235294118 12.5 12 5 decreased cytotoxic T cell cytolysis 0.000595218139460148 0.0108868023669641 1.77726241158249 0.470588235294118 12.5 12 5 hyperlipidemia 0.0144002344368572 0.128822465804225 1.77726241158249 0.470588235294118 12.5 12 5 increased hepatoma incidence 0.0144002344368572 0.128822465804225 1.77726241158249 0.470588235294118 12.5 12 5 increased monocyte cell number 5.27403198834839e-09 4.44717104102258e-07 1.77504083356801 0.47 12.5 12 5 abnormal neural tube closure 1.03712037404632e-07 6.61496648830825e-06 1.77458581156504 0.469879518072289 12.5 12 5 increased spleen weight 6.29002582426384e-10 6.25857569514252e-08 1.77136441685378 0.469026548672566 12.5 12 5 increased circulating follicle stimulating hormone level 0.000924300039367451 0.015482803689741 1.77031998028724 0.46875 12.5 12 5 abnormal embryonic hematopoiesis 0.000924300039367451 0.015482803689741 1.77031998028724 0.46875 12.5 12 5 spleen hypoplasia 3.38901705104764e-09 2.95795786473017e-07 1.76245189148597 0.466666666666667 12.5 12 5 macrocytosis 0.0229935031978532 0.179298868980125 1.76245189148597 0.466666666666667 12.5 12 5 audiogenic seizures 0.0229935031978532 0.179298868980125 1.76245189148597 0.466666666666667 12.5 12 5 increased airway responsiveness 0.0229935031978532 0.179298868980125 1.76245189148597 0.466666666666667 12.5 12 5 delayed intramembranous bone ossification 0.0229935031978532 0.179298868980125 1.76245189148597 0.466666666666667 12.5 12 5 immune system phenotype 0.0229935031978532 0.179298868980125 1.76245189148597 0.466666666666667 12.5 12 5 abnormal energy homeostasis 0.0229935031978532 0.179298868980125 1.76245189148597 0.466666666666667 12.5 12 5 abnormal dendritic cell morphology 0.0229935031978532 0.179298868980125 1.76245189148597 0.466666666666667 12.5 12 5 abnormal microglial cell activation 0.0229935031978532 0.179298868980125 1.76245189148597 0.466666666666667 12.5 12 5 astrocytosis 8.63977316179213e-07 4.29828714799158e-05 1.75900286625801 0.465753424657534 12.5 12 5 enlarged spleen 1.9863493424299e-22 1.41172685408411e-19 1.75720649895178 0.465277777777778 12.5 12 5 anemia 9.69207794535942e-17 2.83635810459783e-14 1.75409903891968 0.464454976303318 12.5 12 5 decreased embryo size 4.17371883520262e-36 1.03821256025665e-32 1.75402414783272 0.464435146443515 12.5 12 5 abnormal spleen germinal center morphology 0.00223907028185884 0.0304354498695292 1.75345978999879 0.464285714285714 12.5 12 5 premature aging 0.00223907028185884 0.0304354498695292 1.75345978999879 0.464285714285714 12.5 12 5 neurodegeneration 2.6893953273977e-05 0.000827599869475335 1.74846417806147 0.462962962962963 12.5 12 5 abnormal leukocyte migration 4.12666238490513e-05 0.00118671360490769 1.74308428828282 0.461538461538462 12.5 12 5 abnormal leukocyte adhesion 0.000370576703147505 0.00777898353653517 1.74308428828282 0.461538461538462 12.5 12 5 decreased circulating glycerol level 0.00349427827792639 0.0442341843070834 1.74308428828282 0.461538461538462 12.5 12 5 pulmonary edema 0.00349427827792639 0.0442341843070834 1.74308428828282 0.461538461538462 12.5 12 5 absent common myeloid progenitor cells 0.0369692510862408 0.246875200206776 1.74308428828282 0.461538461538462 12.5 12 5 increased foot pad pigmentation 0.0369692510862408 0.246875200206776 1.74308428828282 0.461538461538462 12.5 12 5 abnormal grip strength 0.0369692510862408 0.246875200206776 1.74308428828282 0.461538461538462 12.5 12 5 abnormal coping response 0.0369692510862408 0.246875200206776 1.74308428828282 0.461538461538462 12.5 12 5 abnormal exocrine pancreas morphology 0.0369692510862408 0.246875200206776 1.74308428828282 0.461538461538462 12.5 12 5 abnormal vertebral arch development 0.0369692510862408 0.246875200206776 1.74308428828282 0.461538461538462 12.5 12 5 orthokeratosis 0.0369692510862408 0.246875200206776 1.74308428828282 0.461538461538462 12.5 12 5 embryonic lethality between implantation and somite formation, complete penetrance 8.76624670889385e-19 4.8457863751941e-16 1.74189851665814 0.461224489795918 12.5 12 5 abnormal interventricular septum morphology 6.33415623032931e-05 0.00171263191553741 1.73727400732188 0.46 12.5 12 5 decreased T cell number 1.00215988408877e-12 1.78062336547915e-10 1.73586654795867 0.459627329192547 12.5 12 5 decreased cell proliferation 2.20474766583212e-14 4.76896505978903e-12 1.73523255725452 0.459459459459459 12.5 12 5 liver inflammation 8.81035240144855e-10 8.42913523023203e-08 1.73097953628086 0.458333333333333 12.5 12 5 hydrops fetalis 1.94943590971982e-06 8.58269349633283e-05 1.73097953628086 0.458333333333333 12.5 12 5 small heart 9.72595515068681e-05 0.00248425356880768 1.73097953628086 0.458333333333333 12.5 12 5 abnormal humoral immune response 1.12294121301337e-08 8.86767069006592e-07 1.72648348553727 0.457142857142857 12.5 12 5 increased carcinoma incidence 0.000884787783058824 0.0149721742201281 1.72648348553727 0.457142857142857 12.5 12 5 abnormal allantois morphology 0.000149395609194441 0.00353925312258259 1.72413771993192 0.456521739130435 12.5 12 5 pericardial edema 4.53867774460827e-06 0.000176405638901767 1.72172296122053 0.455882352941176 12.5 12 5 abnormal germ layer development 0.00856694608799451 0.0869807281383116 1.71667392027854 0.454545454545455 12.5 12 5 increased activated T cell number 0.00856694608799451 0.0869807281383116 1.71667392027854 0.454545454545455 12.5 12 5 intestinal inflammation 0.00856694608799451 0.0869807281383116 1.71667392027854 0.454545454545455 12.5 12 5 abnormal vascular branching morphogenesis 0.00856694608799451 0.0869807281383116 1.71667392027854 0.454545454545455 12.5 12 5 premature suture closure 0.0599737286901513 0.331521444703892 1.71667392027854 0.454545454545455 12.5 12 5 abnormal stomach epithelium morphology 0.0599737286901513 0.331521444703892 1.71667392027854 0.454545454545455 12.5 12 5 failure of somite differentiation 0.0599737286901513 0.331521444703892 1.71667392027854 0.454545454545455 12.5 12 5 loss of cortex neurons 0.0599737286901513 0.331521444703892 1.71667392027854 0.454545454545455 12.5 12 5 pharyngeal arch hypoplasia 0.0599737286901513 0.331521444703892 1.71667392027854 0.454545454545455 12.5 12 5 cyclopia 0.0599737286901513 0.331521444703892 1.71667392027854 0.454545454545455 12.5 12 5 increased number of Howell-Jolly bodies 0.0599737286901513 0.331521444703892 1.71667392027854 0.454545454545455 12.5 12 5 aorta dilation 0.0599737286901513 0.331521444703892 1.71667392027854 0.454545454545455 12.5 12 5 abnormal extraembryonic ectoderm morphology 0.0599737286901513 0.331521444703892 1.71667392027854 0.454545454545455 12.5 12 5 abnormal pulmonary alveolar sac morphology 0.0599737286901513 0.331521444703892 1.71667392027854 0.454545454545455 12.5 12 5 decreased core body temperature 0.0599737286901513 0.331521444703892 1.71667392027854 0.454545454545455 12.5 12 5 chylous ascites 0.0599737286901513 0.331521444703892 1.71667392027854 0.454545454545455 12.5 12 5 enlarged pericardium 0.00136903261837192 0.0212178731352035 1.71667392027854 0.454545454545455 12.5 12 5 abnormal ovarian folliculogenesis 0.00136903261837192 0.0212178731352035 1.71667392027854 0.454545454545455 12.5 12 5 decreased brown adipose tissue amount 0.00136903261837192 0.0212178731352035 1.71667392027854 0.454545454545455 12.5 12 5 embryonic growth arrest 7.95110039807551e-17 2.63544983720542e-14 1.71517464174554 0.454148471615721 12.5 12 5 increased inflammatory response 9.08239671543022e-08 5.86817190380069e-06 1.70944581956158 0.452631578947368 12.5 12 5 lethality throughout fetal growth and development, incomplete penetrance 2.47403488458785e-13 5.12846814617691e-11 1.70900163460132 0.452513966480447 12.5 12 5 inner cell mass degeneration 0.00212047569812676 0.029141896680057 1.70559860466384 0.451612903225806 12.5 12 5 decreased double-negative T cell number 0.00212047569812676 0.029141896680057 1.70559860466384 0.451612903225806 12.5 12 5 increased lung adenocarcinoma incidence 9.26191956221433e-05 0.00239472054884157 1.70320981109988 0.450980392156863 12.5 12 5 abnormal cell proliferation 0.0134681052354952 0.122646000418505 1.69950718107575 0.45 12.5 12 5 increased urine glucose level 0.0134681052354952 0.122646000418505 1.69950718107575 0.45 12.5 12 5 decreased myocardial infarction size 0.0134681052354952 0.122646000418505 1.69950718107575 0.45 12.5 12 5 dilated vasculature 0.0134681052354952 0.122646000418505 1.69950718107575 0.45 12.5 12 5 increased T cell derived lymphoma incidence 0.000141785108713453 0.00342417920315256 1.69565342329554 0.448979591836735 12.5 12 5 thrombocytopenia 8.90274743027386e-11 1.00661746512756e-08 1.69299565930918 0.448275862068966 12.5 12 5 abnormal spermiogenesis 3.7544552965421e-05 0.00110523166273946 1.69299565930918 0.448275862068966 12.5 12 5 lordosis 0.00328805701926323 0.0418365311274542 1.69299565930918 0.448275862068966 12.5 12 5 internal hemorrhage 1.0038048187129e-05 0.000356709212364049 1.69105192146841 0.447761194029851 12.5 12 5 oxidative stress 4.56755096257044e-07 2.46995283030304e-05 1.67852561093902 0.444444444444444 12.5 12 5 increased neuron apoptosis 1.68376887172835e-06 7.61522739713503e-05 1.67852561093902 0.444444444444444 12.5 12 5 abnormal eye muscle morphology 0.00510479298595389 0.0583042316731443 1.67852561093902 0.444444444444444 12.5 12 5 abnormal mitral valve morphology 0.0212428538455772 0.168553744627985 1.67852561093902 0.444444444444444 12.5 12 5 abnormal mammary gland morphology 0.0212428538455772 0.168553744627985 1.67852561093902 0.444444444444444 12.5 12 5 abnormal iron level 0.0212428538455772 0.168553744627985 1.67852561093902 0.444444444444444 12.5 12 5 abnormal white adipose tissue morphology 0.0212428538455772 0.168553744627985 1.67852561093902 0.444444444444444 12.5 12 5 abnormal neutrophil morphology 0.0212428538455772 0.168553744627985 1.67852561093902 0.444444444444444 12.5 12 5 darkened coat color 0.0212428538455772 0.168553744627985 1.67852561093902 0.444444444444444 12.5 12 5 jerky movement 0.0212428538455772 0.168553744627985 1.67852561093902 0.444444444444444 12.5 12 5 abnormal pregnancy 0.0212428538455772 0.168553744627985 1.67852561093902 0.444444444444444 12.5 12 5 abnormal somite development 2.55306789884351e-06 0.00010855993843373 1.67321382103098 0.443037974683544 12.5 12 5 decreased IgA level 0.000133347097373216 0.00323610638747195 1.67045577627104 0.442307692307692 12.5 12 5 abnormal cytokine secretion 7.57325133845839e-11 8.97069652591203e-09 1.66762609398487 0.441558441558442 12.5 12 5 abnormal brown adipose tissue morphology 0.00197993878593385 0.027867003828864 1.66618351085858 0.441176470588235 12.5 12 5 increased cellular sensitivity to ionizing radiation 0.00793597801427014 0.0827968135307545 1.66174035482963 0.44 12.5 12 5 decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 0.00793597801427014 0.0827968135307545 1.66174035482963 0.44 12.5 12 5 abnormal developmental patterning 2.39879401873708e-06 0.000102879312441526 1.65805578641537 0.439024390243902 12.5 12 5 Leydig cell hyperplasia 0.000779622022218773 0.0134674290296472 1.65805578641537 0.439024390243902 12.5 12 5 liver fibrosis 0.000779622022218773 0.0134674290296472 1.65805578641537 0.439024390243902 12.5 12 5 abnormal cell differentiation 0.000779622022218773 0.0134674290296472 1.65805578641537 0.439024390243902 12.5 12 5 hemopericardium 0.000779622022218773 0.0134674290296472 1.65805578641537 0.439024390243902 12.5 12 5 prenatal lethality, complete penetrance 5.17452113219333e-18 1.98024943328168e-15 1.65739309425453 0.438848920863309 12.5 12 5 decreased brain weight 8.18540118590577e-05 0.00215462279893551 1.65643974763719 0.43859649122807 12.5 12 5 scoliosis 0.00305083454382844 0.0391183037514085 1.65229864826809 0.4375 12.5 12 5 abnormal depression-related behavior 0.00305083454382844 0.0391183037514085 1.65229864826809 0.4375 12.5 12 5 increased fatty acid level 0.00305083454382844 0.0391183037514085 1.65229864826809 0.4375 12.5 12 5 absent mandible 0.0336360422792871 0.230812841847522 1.65229864826809 0.4375 12.5 12 5 intraventricular hemorrhage 0.0336360422792871 0.230812841847522 1.65229864826809 0.4375 12.5 12 5 abnormal epicardium morphology 0.0336360422792871 0.230812841847522 1.65229864826809 0.4375 12.5 12 5 paternal imprinting 0.0336360422792871 0.230812841847522 1.65229864826809 0.4375 12.5 12 5 dystonia 0.0336360422792871 0.230812841847522 1.65229864826809 0.4375 12.5 12 5 impaired somite development 0.0336360422792871 0.230812841847522 1.65229864826809 0.4375 12.5 12 5 decreased liver cholesterol level 0.0336360422792871 0.230812841847522 1.65229864826809 0.4375 12.5 12 5 embryonic lethality during organogenesis, complete penetrance 1.65059814952848e-34 2.7372419313014e-31 1.65229864826809 0.4375 12.5 12 5 abnormal lymph node morphology 0.000310272936047223 0.00674064566303465 1.65229864826809 0.4375 12.5 12 5 abnormal T-helper 2 physiology 0.00012446107604435 0.00303526398686589 1.6480069634674 0.436363636363636 12.5 12 5 increased autoantibody level 0.00119410260576669 0.0191018021340492 1.64624627226711 0.435897435897436 12.5 12 5 increased hepatocyte apoptosis 0.00119410260576669 0.0191018021340492 1.64624627226711 0.435897435897436 12.5 12 5 failure of heart looping 0.00119410260576669 0.0191018021340492 1.64624627226711 0.435897435897436 12.5 12 5 conjunctivitis 0.0123555235263503 0.117083294368748 1.64203592374469 0.434782608695652 12.5 12 5 abnormal hematopoietic stem cell physiology 0.0123555235263503 0.117083294368748 1.64203592374469 0.434782608695652 12.5 12 5 increased metastatic potential 0.00470324929298573 0.0549264442079906 1.63656247066554 0.433333333333333 12.5 12 5 abnormal fat pad morphology 0.00470324929298573 0.0549264442079906 1.63656247066554 0.433333333333333 12.5 12 5 abnormal cellular respiration 0.00470324929298573 0.0549264442079906 1.63656247066554 0.433333333333333 12.5 12 5 increased erythroid progenitor cell number 0.00182897743932605 0.02652817131384 1.63316005388661 0.432432432432432 12.5 12 5 muscular atrophy 0.000721440488469305 0.0126825668909357 1.63084022426461 0.431818181818182 12.5 12 5 abnormal embryonic neuroepithelium morphology 0.000115421783748176 0.00285683270719989 1.62788044164344 0.431034482758621 12.5 12 5 abnormal inflammatory response 1.89125756669999e-05 0.000619013578574502 1.62607168559717 0.430555555555556 12.5 12 5 decreased birth body size 8.952198385364e-08 5.86817190380069e-06 1.62331095268444 0.429824561403509 12.5 12 5 failure of blastocyst to hatch from the zona pellucida 0.00725408501402519 0.0771134037281523 1.61857826769119 0.428571428571429 12.5 12 5 abnormal brainstem morphology 0.00725408501402519 0.0771134037281523 1.61857826769119 0.428571428571429 12.5 12 5 abnormal salivary gland morphology 0.0192671535915306 0.161915691077474 1.61857826769119 0.428571428571429 12.5 12 5 increased acute inflammation 0.0192671535915306 0.161915691077474 1.61857826769119 0.428571428571429 12.5 12 5 midline facial cleft 0.0535074145038573 0.304575957845183 1.61857826769119 0.428571428571429 12.5 12 5 abnormal kidney blood vessel morphology 0.0535074145038573 0.304575957845183 1.61857826769119 0.428571428571429 12.5 12 5 absent visceral yolk sac blood islands 0.0535074145038573 0.304575957845183 1.61857826769119 0.428571428571429 12.5 12 5 abnormal fluid regulation 0.0535074145038573 0.304575957845183 1.61857826769119 0.428571428571429 12.5 12 5 abnormal spleen periarteriolar lymphoid sheath morphology 0.0535074145038573 0.304575957845183 1.61857826769119 0.428571428571429 12.5 12 5 abnormal ventral body wall morphology 0.0535074145038573 0.304575957845183 1.61857826769119 0.428571428571429 12.5 12 5 abnormal vascular endothelial cell migration 0.0535074145038573 0.304575957845183 1.61857826769119 0.428571428571429 12.5 12 5 abnormal sagittal suture morphology 0.0535074145038573 0.304575957845183 1.61857826769119 0.428571428571429 12.5 12 5 abnormal maternal decidual layer morphology 0.0535074145038573 0.304575957845183 1.61857826769119 0.428571428571429 12.5 12 5 split sternum 0.0535074145038573 0.304575957845183 1.61857826769119 0.428571428571429 12.5 12 5 abnormal glucose tolerance 0.0535074145038573 0.304575957845183 1.61857826769119 0.428571428571429 12.5 12 5 spina bifida occulta 0.0535074145038573 0.304575957845183 1.61857826769119 0.428571428571429 12.5 12 5 pulmonary alveolar hemorrhage 0.0535074145038573 0.304575957845183 1.61857826769119 0.428571428571429 12.5 12 5 abnormal renal tubule epithelial cell primary cilium morphology 0.0535074145038573 0.304575957845183 1.61857826769119 0.428571428571429 12.5 12 5 testis degeneration 0.0535074145038573 0.304575957845183 1.61857826769119 0.428571428571429 12.5 12 5 abnormal vitelline vein topology 0.0535074145038573 0.304575957845183 1.61857826769119 0.428571428571429 12.5 12 5 decreased erythrocyte cell number 6.19314467578886e-10 6.25857569514252e-08 1.61170532387934 0.426751592356688 12.5 12 5 abnormal pancreatic beta cell morphology 0.00167552429579665 0.0246527753036625 1.60509011546043 0.425 12.5 12 5 decreased IgG level 2.78867725067976e-07 1.61321736303858e-05 1.59913588609731 0.423423423423423 12.5 12 5 abnormal leukocyte cell number 0.0111932244875889 0.107089022741836 1.59782726425926 0.423076923076923 12.5 12 5 decreased IgM level 1.65081893233844e-06 7.5347010902603e-05 1.59632976916623 0.422680412371134 12.5 12 5 decreased caudal vertebrae number 9.77168800334038e-05 0.00248425356880768 1.59328798225852 0.421875 12.5 12 5 kyphoscoliosis 0.0300971665940819 0.21581784464635 1.5901821577317 0.421052631578947 12.5 12 5 irregular coat pigmentation 0.0300971665940819 0.21581784464635 1.5901821577317 0.421052631578947 12.5 12 5 unresponsive to tactile stimuli 0.0300971665940819 0.21581784464635 1.5901821577317 0.421052631578947 12.5 12 5 increased malignant tumor incidence 0.0300971665940819 0.21581784464635 1.5901821577317 0.421052631578947 12.5 12 5 abnormal vitelline vasculature morphology 3.51494084575331e-07 1.94298118973586e-05 1.5763544867949 0.417391304347826 12.5 12 5 intracranial hemorrhage 0.000221118295850435 0.00502312110436491 1.57361776025533 0.416666666666667 12.5 12 5 muscular ventricular septal defect 0.000221118295850435 0.00502312110436491 1.57361776025533 0.416666666666667 12.5 12 5 abnormal adrenal gland morphology 0.0172775514659649 0.147437081549186 1.57361776025533 0.416666666666667 12.5 12 5 decreased metastatic potential 0.0172775514659649 0.147437081549186 1.57361776025533 0.416666666666667 12.5 12 5 small lymph nodes 0.0172775514659649 0.147437081549186 1.57361776025533 0.416666666666667 12.5 12 5 increased hemangiosarcoma incidence 0.0172775514659649 0.147437081549186 1.57361776025533 0.416666666666667 12.5 12 5 abnormal supraoccipital bone morphology 0.0855987400061352 0.411055725415563 1.57361776025533 0.416666666666667 12.5 12 5 amyloidosis 0.0855987400061352 0.411055725415563 1.57361776025533 0.416666666666667 12.5 12 5 abnormal mating frequency 0.0855987400061352 0.411055725415563 1.57361776025533 0.416666666666667 12.5 12 5 abnormal gastrocnemius morphology 0.0855987400061352 0.411055725415563 1.57361776025533 0.416666666666667 12.5 12 5 abnormal B cell proliferation 0.0855987400061352 0.411055725415563 1.57361776025533 0.416666666666667 12.5 12 5 abnormal thymus corticomedullary boundary morphology 0.0855987400061352 0.411055725415563 1.57361776025533 0.416666666666667 12.5 12 5 decreased red blood cell distribution width 0.0855987400061352 0.411055725415563 1.57361776025533 0.416666666666667 12.5 12 5 decreased mammary gland epithelial cell proliferation 0.0855987400061352 0.411055725415563 1.57361776025533 0.416666666666667 12.5 12 5 abnormal pulmonary valve cusp morphology 0.0855987400061352 0.411055725415563 1.57361776025533 0.416666666666667 12.5 12 5 prenatal growth retardation 0.0855987400061352 0.411055725415563 1.57361776025533 0.416666666666667 12.5 12 5 abnormal trophoblast giant cell morphology 0.00388396297449486 0.047359597544392 1.57361776025533 0.416666666666667 12.5 12 5 abnormal embryo size 5.23677586684336e-07 2.77159148271763e-05 1.57083259607788 0.415929203539823 12.5 12 5 preweaning lethality, complete penetrance 1.48937583340704e-37 7.40964477120001e-34 1.56681292669747 0.414864864864865 12.5 12 5 sparse hair 2.01813093984271e-05 0.000651961131540098 1.56594157605896 0.414634146341463 12.5 12 5 arrested B cell differentiation 0.00231012173958098 0.0309780475860253 1.56594157605896 0.414634146341463 12.5 12 5 abnormal hepatocyte morphology 7.79595894542209e-07 3.99844286118298e-05 1.565111718308 0.414414414414414 12.5 12 5 increased double-positive T cell number 0.0100536341867983 0.0969318412389956 1.5627652239777 0.413793103448276 12.5 12 5 embryonic lethality, complete penetrance 8.47581857191694e-17 2.63544983720542e-14 1.5627652239777 0.413793103448276 12.5 12 5 atrial septal defect 0.00138050670338975 0.0213292572961616 1.55993412755745 0.41304347826087 12.5 12 5 abnormal vertebrae morphology 1.1596222432639e-06 5.65600064729204e-05 1.5591809000695 0.412844036697248 12.5 12 5 abnormal direction of heart looping 0.00590713977571601 0.0643063903373898 1.55510461013468 0.411764705882353 12.5 12 5 increased incidence of corneal inflammation 0.0471011077689881 0.275680013118489 1.55510461013468 0.411764705882353 12.5 12 5 abnormal dorsal-ventral axis patterning 0.0471011077689881 0.275680013118489 1.55510461013468 0.411764705882353 12.5 12 5 lethality throughout fetal growth and development, complete penetrance 2.41798133162574e-10 2.67321269440846e-08 1.55042760378841 0.410526315789474 12.5 12 5 increased B cell number 6.47113451011155e-07 3.37911322219101e-05 1.5494082562514 0.41025641025641 12.5 12 5 teratozoospermia 1.66682753653685e-05 0.000560301823937218 1.54500652825068 0.409090909090909 12.5 12 5 embryonic lethality, incomplete penetrance 0.00208112801700366 0.0288401445253293 1.54500652825068 0.409090909090909 12.5 12 5 aphakia 0.0266749895555171 0.197188815807872 1.54500652825068 0.409090909090909 12.5 12 5 abnormal mesenteric lymph node morphology 0.0266749895555171 0.197188815807872 1.54500652825068 0.409090909090909 12.5 12 5 abnormal sperm midpiece morphology 0.0266749895555171 0.197188815807872 1.54500652825068 0.409090909090909 12.5 12 5 pulmonary vascular congestion 0.0266749895555171 0.197188815807872 1.54500652825068 0.409090909090909 12.5 12 5 abnormal spermatogenesis 7.80181225148939e-10 7.61059136297249e-08 1.53940867851065 0.407608695652174 12.5 12 5 decreased heart weight 4.06848095664631e-05 0.0011767844627509 1.5386484766941 0.407407407407407 12.5 12 5 thick interventricular septum 0.015379021144963 0.133745824052222 1.5386484766941 0.407407407407407 12.5 12 5 abnormal heart morphology 6.73169667348064e-12 9.30283081960171e-10 1.53683189053507 0.406926406926407 12.5 12 5 increased leukocyte cell number 5.11632128614682e-08 3.53523588869173e-06 1.53671913691141 0.406896551724138 12.5 12 5 failure of primitive streak formation 0.00897546820165279 0.0896852534878534 1.53427731624894 0.40625 12.5 12 5 retinal degeneration 9.21044416695103e-06 0.000329654386550945 1.53427731624894 0.40625 12.5 12 5 decreased spleen weight 0.000164240843367666 0.00378286201738027 1.53256686216171 0.405797101449275 12.5 12 5 pallor 2.75989059322375e-09 2.45186708951574e-07 1.53225409341433 0.405714285714286 12.5 12 5 increased granulocyte number 9.95597866034184e-05 0.00251426364645689 1.5310875505187 0.405405405405405 12.5 12 5 abnormal respiratory electron transport chain 0.00528508947574635 0.0600304112827353 1.5310875505187 0.405405405405405 12.5 12 5 abnormal placenta labyrinth morphology 6.04528213445138e-05 0.00165248783620305 1.52979549351404 0.40506329113924 12.5 12 5 abnormal visceral yolk sac morphology 6.04528213445138e-05 0.00165248783620305 1.52979549351404 0.40506329113924 12.5 12 5 abnormal response to infection 6.04528213445138e-05 0.00165248783620305 1.52979549351404 0.40506329113924 12.5 12 5 hemorrhage 8.16010205026934e-12 1.09720291081324e-09 1.52674403973708 0.404255319148936 12.5 12 5 distended pericardium 0.00111785577809449 0.0181742892026801 1.52519875224747 0.403846153846154 12.5 12 5 incomplete embryo turning 0.000671517687867156 0.0118468102735429 1.52392456782621 0.403508771929825 12.5 12 5 abnormal spleen morphology 5.41905093281226e-09 4.49329639845683e-07 1.51935507886721 0.402298850574713 12.5 12 5 abnormal lung development 4.90261294603305e-05 0.00137799431675223 1.51067304984511 0.4 12.5 12 5 enlarged liver 1.10877923275493e-05 0.000385746621185717 1.51067304984511 0.4 12.5 12 5 absent mesoderm 0.000602096066904195 0.0109198083487904 1.51067304984511 0.4 12.5 12 5 increased erythrocyte cell number 0.000602096066904195 0.0109198083487904 1.51067304984511 0.4 12.5 12 5 abnormal liver development 0.00797769826746659 0.0827968135307545 1.51067304984511 0.4 12.5 12 5 thick pulmonary interalveolar septum 0.00797769826746659 0.0827968135307545 1.51067304984511 0.4 12.5 12 5 increased circulating serum albumin level 0.00797769826746659 0.0827968135307545 1.51067304984511 0.4 12.5 12 5 disorganized myocardium 0.0136205574493401 0.122980532323897 1.51067304984511 0.4 12.5 12 5 liver hemorrhage 0.0136205574493401 0.122980532323897 1.51067304984511 0.4 12.5 12 5 abnormal optic cup morphology 0.0136205574493401 0.122980532323897 1.51067304984511 0.4 12.5 12 5 abnormal egg cylinder morphology 0.0235052671004281 0.179487020216319 1.51067304984511 0.4 12.5 12 5 waved hair 0.0411832074998064 0.260338573458116 1.51067304984511 0.4 12.5 12 5 abnormal hair texture 0.0411832074998064 0.260338573458116 1.51067304984511 0.4 12.5 12 5 abnormal Peyer's patch T cell area morphology 0.0411832074998064 0.260338573458116 1.51067304984511 0.4 12.5 12 5 absent incisors 0.0738500220411935 0.368509387818393 1.51067304984511 0.4 12.5 12 5 abnormal lymph node B cell domain morphology 0.0738500220411935 0.368509387818393 1.51067304984511 0.4 12.5 12 5 abnormal pericyte morphology 0.0738500220411935 0.368509387818393 1.51067304984511 0.4 12.5 12 5 abnormal placenta size 0.0738500220411935 0.368509387818393 1.51067304984511 0.4 12.5 12 5 liver vascular congestion 0.0738500220411935 0.368509387818393 1.51067304984511 0.4 12.5 12 5 bicuspid aortic valve 0.0738500220411935 0.368509387818393 1.51067304984511 0.4 12.5 12 5 short tail 7.24088634252702e-05 0.0019263855376509 1.50157260978581 0.397590361445783 12.5 12 5 decreased mean corpuscular hemoglobin 0.000325150003914603 0.00703313595423977 1.49956515977272 0.397058823529412 12.5 12 5 increased circulating bilirubin level 0.00149020559011456 0.0226720881064829 1.49642141729941 0.39622641509434 12.5 12 5 abnormal eye morphology 4.23140862938259e-07 2.31332504738224e-05 1.49437082268851 0.39568345323741 12.5 12 5 small spleen 3.94828834247345e-05 0.00114869792419915 1.49407224709956 0.395604395604396 12.5 12 5 abnormal homeostasis 0.00418485344929634 0.049997144539694 1.49310708414924 0.395348837209302 12.5 12 5 abnormal double-strand DNA break repair 0.00418485344929634 0.049997144539694 1.49310708414924 0.395348837209302 12.5 12 5 incomplete somite formation 0.00706768539061038 0.0756166340178208 1.49079577287347 0.394736842105263 12.5 12 5 abnormal embryonic tissue morphology 2.33149462772098e-07 1.38085544915618e-05 1.49011967501729 0.394557823129252 12.5 12 5 abnormal ovary morphology 0.000290624808430888 0.00642603743086074 1.48939596463603 0.394366197183099 12.5 12 5 dilated heart atrium 0.0120209854728358 0.114348762385006 1.4877840642414 0.393939393939394 12.5 12 5 shortened head 0.0206363327590991 0.166125817923169 1.48369674538359 0.392857142857143 12.5 12 5 abnormal somite shape 0.0206363327590991 0.166125817923169 1.48369674538359 0.392857142857143 12.5 12 5 abnormal renal tubule epithelium morphology 0.0206363327590991 0.166125817923169 1.48369674538359 0.392857142857143 12.5 12 5 abnormal mitotic spindle morphology 0.0206363327590991 0.166125817923169 1.48369674538359 0.392857142857143 12.5 12 5 abnormal cued conditioning behavior 0.00221378546616553 0.0302570953136635 1.48105200965207 0.392156862745098 12.5 12 5 increased lymphocyte cell number 0.000428591607123348 0.00846128271999467 1.47783233137022 0.391304347826087 12.5 12 5 perimembraneous ventricular septal defect 0.000428591607123348 0.00846128271999467 1.47783233137022 0.391304347826087 12.5 12 5 abnormal cranial nerve morphology 0.0358803605742672 0.242533687305678 1.47783233137022 0.391304347826087 12.5 12 5 pancreas inflammation 0.0358803605742672 0.242533687305678 1.47783233137022 0.391304347826087 12.5 12 5 abnormal sacral vertebrae morphology 0.0358803605742672 0.242533687305678 1.47783233137022 0.391304347826087 12.5 12 5 abnormal regulatory T cell physiology 0.0358803605742672 0.242533687305678 1.47783233137022 0.391304347826087 12.5 12 5 scaly skin 0.00624601580810955 0.0674054851309002 1.47382736570255 0.390243902439024 12.5 12 5 increased cell proliferation 0.00196320191180292 0.027867003828864 1.46870990957164 0.388888888888889 12.5 12 5 abnormal pharyngeal arch morphology 0.0105828025448122 0.101639850695832 1.46870990957164 0.388888888888889 12.5 12 5 cortical renal glomerulopathies 0.0635563602657041 0.334081768004696 1.46870990957164 0.388888888888889 12.5 12 5 abnormal thymus cortex morphology 0.0635563602657041 0.334081768004696 1.46870990957164 0.388888888888889 12.5 12 5 decreased cellular sensitivity to gamma-irradiation 0.0635563602657041 0.334081768004696 1.46870990957164 0.388888888888889 12.5 12 5 increased susceptibility to autoimmune disorder 0.0635563602657041 0.334081768004696 1.46870990957164 0.388888888888889 12.5 12 5 increased gastrointestinal tumor incidence 0.0635563602657041 0.334081768004696 1.46870990957164 0.388888888888889 12.5 12 5 increased effector memory CD4-positive, alpha-beta T cell number 0.0635563602657041 0.334081768004696 1.46870990957164 0.388888888888889 12.5 12 5 abnormal aerobic respiration 0.0635563602657041 0.334081768004696 1.46870990957164 0.388888888888889 12.5 12 5 abnormal respiratory system physiology 0.00328159623900537 0.0418365311274542 1.46442795648251 0.387755102040816 12.5 12 5 prenatal lethality 0.00104575942707261 0.0171139906239679 1.46194166114043 0.387096774193548 12.5 12 5 autoimmune response 0.0180744342942949 0.152407306125623 1.46194166114043 0.387096774193548 12.5 12 5 abnormal mitochondrial ATP synthesis coupled electron transport 0.0180744342942949 0.152407306125623 1.46194166114043 0.387096774193548 12.5 12 5 embryonic lethality during organogenesis, incomplete penetrance 5.38791385924805e-10 5.64139468327553e-08 1.46141197213277 0.38695652173913 12.5 12 5 abnormal neurocranium morphology 0.000339023202236482 0.00727000185830388 1.46031728151694 0.386666666666667 12.5 12 5 increased neutrophil cell number 8.43934876151444e-07 4.24098586752872e-05 1.45858087571252 0.386206896551724 12.5 12 5 small liver 0.000300989843474658 0.00656765118985273 1.45257024023569 0.384615384615385 12.5 12 5 abnormal snout morphology 0.00289874152120992 0.0375553100729671 1.45257024023569 0.384615384615385 12.5 12 5 abnormal circulating hormone level 0.00929983625558506 0.0902893515717166 1.45257024023569 0.384615384615385 12.5 12 5 tight skin 0.115992170581069 0.485741623435032 1.45257024023569 0.384615384615385 12.5 12 5 abnormal digestion 0.115992170581069 0.485741623435032 1.45257024023569 0.384615384615385 12.5 12 5 lymphoid hypoplasia 0.115992170581069 0.485741623435032 1.45257024023569 0.384615384615385 12.5 12 5 abnormal pulmonary alveolus epithelial cell morphology 0.115992170581069 0.485741623435032 1.45257024023569 0.384615384615385 12.5 12 5 tracheoesophageal fistula 0.115992170581069 0.485741623435032 1.45257024023569 0.384615384615385 12.5 12 5 small otic vesicle 0.115992170581069 0.485741623435032 1.45257024023569 0.384615384615385 12.5 12 5 decreased endocochlear potential 0.115992170581069 0.485741623435032 1.45257024023569 0.384615384615385 12.5 12 5 empty decidua capsularis 0.115992170581069 0.485741623435032 1.45257024023569 0.384615384615385 12.5 12 5 abnormal seminiferous tubule morphology 1.09163336401309e-06 5.37710493659915e-05 1.44859059574189 0.383561643835616 12.5 12 5 abnormal T-helper 1 physiology 0.00485255966468138 0.0564053372238081 1.44638909027724 0.382978723404255 12.5 12 5 abnormal neural tube morphology 3.27619442427548e-07 1.87345600698512e-05 1.44539705386415 0.382716049382716 12.5 12 5 ventricular septal defect 2.89152829372935e-06 0.000119962323147254 1.44402570941077 0.382352941176471 12.5 12 5 decreased circulating alanine transaminase level 0.000820079189645986 0.0141172801677812 1.44402570941077 0.382352941176471 12.5 12 5 abnormal endoderm development 0.0158057470948622 0.136516652425242 1.44402570941077 0.382352941176471 12.5 12 5 abnormal muscle physiology 0.000144048625511412 0.00342951074191261 1.44277763187455 0.382022471910112 12.5 12 5 decreased rib number 0.000144048625511412 0.00342951074191261 1.44277763187455 0.382022471910112 12.5 12 5 abnormal head morphology 0.00255737627826669 0.0335697809614163 1.44200609303397 0.381818181818182 12.5 12 5 abnormal platelet physiology 0.00255737627826669 0.0335697809614163 1.44200609303397 0.381818181818182 12.5 12 5 gliosis 0.00135785034831084 0.0212178731352035 1.43873623794773 0.380952380952381 12.5 12 5 skin edema 0.00816156961847253 0.0837191935090739 1.43873623794773 0.380952380952381 12.5 12 5 decreased cochlear outer hair cell number 0.0546700099048991 0.308721111551502 1.43873623794773 0.380952380952381 12.5 12 5 embryonic lethality at implantation, complete penetrance 0.0546700099048991 0.308721111551502 1.43873623794773 0.380952380952381 12.5 12 5 increased muscle cell glucose uptake 0.0546700099048991 0.308721111551502 1.43873623794773 0.380952380952381 12.5 12 5 abnormal placenta morphology 0.000389009415260914 0.00799719768976466 1.43418327516941 0.379746835443038 12.5 12 5 abnormal myocardium layer morphology 0.000389009415260914 0.00799719768976466 1.43418327516941 0.379746835443038 12.5 12 5 short sternum 0.0271035374421718 0.19887920173275 1.43253478864623 0.379310344827586 12.5 12 5 blood in lymph vessels 0.0271035374421718 0.19887920173275 1.43253478864623 0.379310344827586 12.5 12 5 abnormal craniofacial morphology 6.12654583774861e-05 0.00166555002966117 1.43000604232911 0.378640776699029 12.5 12 5 abnormal angiogenesis 0.000640634201625742 0.0114234951723587 1.42901504715078 0.378378378378378 12.5 12 5 abnormal chromosome morphology 0.0138074974564176 0.124217540408097 1.42901504715078 0.378378378378378 12.5 12 5 lethality at weaning, complete penetrance 0.00715560850965281 0.0763930307629243 1.42674676929816 0.377777777777778 12.5 12 5 abnormal placenta development 0.00375239966126777 0.0462083869178395 1.42516325457086 0.377358490566038 12.5 12 5 atrioventricular septal defect 0.00375239966126777 0.0462083869178395 1.42516325457086 0.377358490566038 12.5 12 5 preweaning lethality, incomplete penetrance 5.26498054624244e-15 1.19060355534346e-12 1.42202719850946 0.376528117359413 12.5 12 5 decreased neutrophil cell number 2.60932150744602e-05 0.000816438647770059 1.42029090156378 0.376068376068376 12.5 12 5 decreased hemoglobin content 4.21985225687771e-06 0.000167329261505501 1.41960410712395 0.375886524822695 12.5 12 5 abnormal osteoclast physiology 0.00174664576342113 0.0254080779912869 1.41625598422979 0.375 12.5 12 5 neonatal lethality 0.0235338139498802 0.179487020216319 1.41625598422979 0.375 12.5 12 5 abnormal lumbar vertebrae morphology 0.0235338139498802 0.179487020216319 1.41625598422979 0.375 12.5 12 5 abnormal tympanic ring morphology 0.0979784098983373 0.455716547688271 1.41625598422979 0.375 12.5 12 5 vasculature congestion 0.0979784098983373 0.455716547688271 1.41625598422979 0.375 12.5 12 5 abnormal hair follicle orientation 0.0979784098983373 0.455716547688271 1.41625598422979 0.375 12.5 12 5 reduced male mating frequency 0.0979784098983373 0.455716547688271 1.41625598422979 0.375 12.5 12 5 poor circulation 0.0979784098983373 0.455716547688271 1.41625598422979 0.375 12.5 12 5 disorganized yolk sac vascular plexus 0.0979784098983373 0.455716547688271 1.41625598422979 0.375 12.5 12 5 abnormal meiosis 0.0979784098983373 0.455716547688271 1.41625598422979 0.375 12.5 12 5 abnormal olfaction 0.0979784098983373 0.455716547688271 1.41625598422979 0.375 12.5 12 5 large intestinal inflammation 0.0979784098983373 0.455716547688271 1.41625598422979 0.375 12.5 12 5 increased pancreatic beta cell number 0.0979784098983373 0.455716547688271 1.41625598422979 0.375 12.5 12 5 increased thymus weight 0.0979784098983373 0.455716547688271 1.41625598422979 0.375 12.5 12 5 abnormal forebrain development 0.000931337934867403 0.0155483430401521 1.41625598422979 0.375 12.5 12 5 overriding aortic valve 0.00626908618475628 0.067508016816369 1.41625598422979 0.375 12.5 12 5 decreased body height 0.0470420460392487 0.275680013118489 1.41625598422979 0.375 12.5 12 5 hemolytic anemia 0.0470420460392487 0.275680013118489 1.41625598422979 0.375 12.5 12 5 abnormal retinal ganglion layer morphology 0.0470420460392487 0.275680013118489 1.41625598422979 0.375 12.5 12 5 decreased white adipose tissue amount 0.00153617128051419 0.0230889792161876 1.40920993455701 0.373134328358209 12.5 12 5 kinked tail 0.000112990123318982 0.00281062931755967 1.40699940916947 0.372549019607843 12.5 12 5 impaired hematopoiesis 0.0054894478200437 0.0619274442283842 1.40699940916947 0.372549019607843 12.5 12 5 abnormal blood vessel morphology 4.75302782172893e-06 0.000183304755140321 1.40648870157993 0.372413793103448 12.5 12 5 ovary cysts 0.0204314123110506 0.165547681184815 1.40276783199903 0.371428571428571 12.5 12 5 abnormal midbrain development 0.0204314123110506 0.165547681184815 1.40276783199903 0.371428571428571 12.5 12 5 holoprosencephaly 0.0204314123110506 0.165547681184815 1.40276783199903 0.371428571428571 12.5 12 5 decreased circulating thyroxine level 0.0204314123110506 0.165547681184815 1.40276783199903 0.371428571428571 12.5 12 5 abnormal hippocampus pyramidal cell morphology 0.0204314123110506 0.165547681184815 1.40276783199903 0.371428571428571 12.5 12 5 pericardial effusion 0.0025386288683735 0.033500473793523 1.40102742525958 0.370967741935484 12.5 12 5 anophthalmia 0.000341729451712091 0.00729658378655645 1.40034299564294 0.370786516853933 12.5 12 5 abnormal small intestine morphology 0.00480486892565882 0.0559817866631209 1.39877134244918 0.37037037037037 12.5 12 5 abnormal brain commissure morphology 0.0405069246678583 0.257043303855351 1.39877134244918 0.37037037037037 12.5 12 5 abnormal liver physiology 0.000162522896555224 0.00376070423424298 1.39737257110673 0.37 12.5 12 5 decreased hematocrit 6.01726068784445e-06 0.000228518106275009 1.39685521732254 0.36986301369863 12.5 12 5 seminiferous tubule degeneration 0.00118665063791862 0.0191018021340492 1.39685521732254 0.36986301369863 12.5 12 5 abnormal lung morphology 4.21356502586042e-05 0.00120474057492274 1.39642046624338 0.369747899159664 12.5 12 5 abnormal myelin sheath morphology 0.00917583799503867 0.0896852534878534 1.39573053518299 0.369565217391304 12.5 12 5 increased bone marrow cell number 0.0177390544948051 0.150857771131035 1.39140938801524 0.368421052631579 12.5 12 5 decreased neuron apoptosis 0.0177390544948051 0.150857771131035 1.39140938801524 0.368421052631579 12.5 12 5 short vibrissae 0.0830742232408171 0.405588086970623 1.39140938801524 0.368421052631579 12.5 12 5 altered susceptibility to infection 0.0830742232408171 0.405588086970623 1.39140938801524 0.368421052631579 12.5 12 5 increased susceptibility to ischemic brain injury 0.0830742232408171 0.405588086970623 1.39140938801524 0.368421052631579 12.5 12 5 decreased liver regeneration 0.0830742232408171 0.405588086970623 1.39140938801524 0.368421052631579 12.5 12 5 Leydig cell hypoplasia 0.0830742232408171 0.405588086970623 1.39140938801524 0.368421052631579 12.5 12 5 increased liver cholesterol level 0.0830742232408171 0.405588086970623 1.39140938801524 0.368421052631579 12.5 12 5 shortened RR interval 0.0830742232408171 0.405588086970623 1.39140938801524 0.368421052631579 12.5 12 5 premature death 3.76404043451556e-27 3.74522023234299e-24 1.38609954631549 0.367015098722416 12.5 12 5 abnormal hair cycle 0.0349094732274955 0.237260422550259 1.38478362902469 0.366666666666667 12.5 12 5 gastrointestinal hemorrhage 0.0349094732274955 0.237260422550259 1.38478362902469 0.366666666666667 12.5 12 5 abnormal spleen marginal zone morphology 0.0349094732274955 0.237260422550259 1.38478362902469 0.366666666666667 12.5 12 5 abnormal brain morphology 3.23072298838752e-06 0.000131744646452688 1.38400170715624 0.366459627329193 12.5 12 5 edema 1.56111205150556e-06 7.19123375577793e-05 1.38331979855003 0.366279069767442 12.5 12 5 increased circulating free fatty acid level 0.00171169661736563 0.0249726999161115 1.3830105385906 0.366197183098592 12.5 12 5 abnormal coat/hair pigmentation 9.78721003992573e-05 0.00248425356880768 1.38253560365289 0.366071428571429 12.5 12 5 thick ventricular wall 0.0154042929008891 0.133745824052222 1.38171315534614 0.365853658536585 12.5 12 5 absent corpus luteum 0.00698106659816014 0.0748508757022559 1.3799417282239 0.365384615384615 12.5 12 5 small seminiferous tubules 0.00150031965451241 0.0226872045021253 1.37797879546683 0.364864864864865 12.5 12 5 kidney cysts 0.00150031965451241 0.0226872045021253 1.37797879546683 0.364864864864865 12.5 12 5 abnormal contextual conditioning behavior 0.00608915043845431 0.0658554857202395 1.37333913622283 0.363636363636364 12.5 12 5 abnormal rostral-caudal axis patterning 0.00608915043845431 0.0658554857202395 1.37333913622283 0.363636363636364 12.5 12 5 decreased circulating total protein level 0.00608915043845431 0.0658554857202395 1.37333913622283 0.363636363636364 12.5 12 5 increased mean corpuscular hemoglobin 0.000293392372396444 0.00645852678173589 1.37333913622283 0.363636363636364 12.5 12 5 decreased blood urea nitrogen level 0.0133802683626531 0.122646000418505 1.37333913622283 0.363636363636364 12.5 12 5 lethality, incomplete penetrance 0.0133802683626531 0.122646000418505 1.37333913622283 0.363636363636364 12.5 12 5 abnormal aorta morphology 0.03011257307962 0.21581784464635 1.37333913622283 0.363636363636364 12.5 12 5 decreased systemic arterial blood pressure 0.03011257307962 0.21581784464635 1.37333913622283 0.363636363636364 12.5 12 5 increased osteoblast cell number 0.03011257307962 0.21581784464635 1.37333913622283 0.363636363636364 12.5 12 5 abnormal long bone epiphysis morphology 0.0706671643902603 0.355479416422189 1.37333913622283 0.363636363636364 12.5 12 5 increased body size 0.0706671643902603 0.355479416422189 1.37333913622283 0.363636363636364 12.5 12 5 intracerebral hemorrhage 0.0706671643902603 0.355479416422189 1.37333913622283 0.363636363636364 12.5 12 5 abnormal oogenesis 0.0706671643902603 0.355479416422189 1.37333913622283 0.363636363636364 12.5 12 5 increased skin papilloma incidence 0.0706671643902603 0.355479416422189 1.37333913622283 0.363636363636364 12.5 12 5 parakeratosis 0.0706671643902603 0.355479416422189 1.37333913622283 0.363636363636364 12.5 12 5 abnormal retinal layer morphology 0.0706671643902603 0.355479416422189 1.37333913622283 0.363636363636364 12.5 12 5 cleft upper lip 0.0706671643902603 0.355479416422189 1.37333913622283 0.363636363636364 12.5 12 5 decreased circulating estradiol level 0.0706671643902603 0.355479416422189 1.37333913622283 0.363636363636364 12.5 12 5 decreased susceptibility to viral infection induced morbidity/mortality 0.0706671643902603 0.355479416422189 1.37333913622283 0.363636363636364 12.5 12 5 abnormal cerebral cortex pyramidal cell morphology 0.0706671643902603 0.355479416422189 1.37333913622283 0.363636363636364 12.5 12 5 rough coat 0.0706671643902603 0.355479416422189 1.37333913622283 0.363636363636364 12.5 12 5 abnormal rib morphology 2.81688413359385e-05 0.00085473918257351 1.3707959156002 0.362962962962963 12.5 12 5 perinatal lethality, incomplete penetrance 7.39672430721638e-08 4.9727977605948e-06 1.37030077530198 0.36283185840708 12.5 12 5 limb grasping 1.34142271790346e-06 6.35578859197114e-05 1.36956622650793 0.362637362637363 12.5 12 5 increased grip strength 0.000543399986258159 0.0101351090224606 1.36956622650793 0.362637362637363 12.5 12 5 hyperkeratosis 0.00246143075503387 0.0325681329954614 1.36836326978724 0.36231884057971 12.5 12 5 hepatic necrosis 0.0116256957155744 0.110800452461653 1.36603414081739 0.361702127659574 12.5 12 5 neuron degeneration 0.0116256957155744 0.110800452461653 1.36603414081739 0.361702127659574 12.5 12 5 increased susceptibility to bacterial infection induced morbidity/mortality 0.00215276891616896 0.0295042020879906 1.36380205888795 0.361111111111111 12.5 12 5 delayed bone ossification 0.00188282095068923 0.0272297506676712 1.3596057448606 0.36 12.5 12 5 spontaneous skin ulceration 0.0602814841923352 0.332852812271773 1.3596057448606 0.36 12.5 12 5 postnatal growth retardation 4.55351418336381e-18 1.88781108851958e-15 1.35763100884773 0.359477124183007 12.5 12 5 increased sacral vertebrae number 0.00404273279403717 0.0486660147998291 1.35724531822022 0.359375 12.5 12 5 small testis 6.98082723933839e-09 5.6933795927391e-07 1.35467963708937 0.358695652173913 12.5 12 5 azoospermia 1.01227654865209e-05 0.00035716849854923 1.35390509184232 0.358490566037736 12.5 12 5 abnormal coat/ hair morphology 0.00878532165112942 0.0889729832853589 1.35390509184232 0.358490566037736 12.5 12 5 rib fusion 0.0035276622680258 0.0445434512269755 1.35284153717473 0.358208955223881 12.5 12 5 abnormal skeleton development 0.00144035207220088 0.0220486316022823 1.35214563103421 0.358024691358025 12.5 12 5 enlarged heart 1.25182614959973e-07 7.78479386782329e-06 1.35114076656406 0.357758620689655 12.5 12 5 arrest of spermatogenesis 0.00125987685789854 0.0200893825898886 1.34881522307599 0.357142857142857 12.5 12 5 disheveled coat 0.0194280280577874 0.162717911763455 1.34881522307599 0.357142857142857 12.5 12 5 abnormal reproductive system morphology 0.0194280280577874 0.162717911763455 1.34881522307599 0.357142857142857 12.5 12 5 rib bifurcation 0.0515461423949467 0.299232273529591 1.34881522307599 0.357142857142857 12.5 12 5 small superior cervical ganglion 0.0515461423949467 0.299232273529591 1.34881522307599 0.357142857142857 12.5 12 5 increased triglyceride level 0.0515461423949467 0.299232273529591 1.34881522307599 0.357142857142857 12.5 12 5 abnormal blood flow velocity 0.150705923957298 0.602218451154665 1.34881522307599 0.357142857142857 12.5 12 5 absent otoliths 0.150705923957298 0.602218451154665 1.34881522307599 0.357142857142857 12.5 12 5 abnormal imprinting 0.150705923957298 0.602218451154665 1.34881522307599 0.357142857142857 12.5 12 5 abnormal pulmonary alveolus morphology 0.000456599893579415 0.00897859474528691 1.34614430184218 0.356435643564356 12.5 12 5 decreased total body fat amount 3.60288433773714e-10 3.89659773483527e-08 1.3455845279309 0.356287425149701 12.5 12 5 decreased percent body fat/body weight 0.00268721732541384 0.035088992634997 1.34511983890318 0.356164383561644 12.5 12 5 abnormal thoracic vertebrae morphology 0.00664793542873773 0.0714329994772575 1.34424296808252 0.355932203389831 12.5 12 5 cachexia 0.000400036133529306 0.00815647444388647 1.34362747221801 0.355769230769231 12.5 12 5 increased susceptibility to parasitic infection 0.000964108160736592 0.0159350102978889 1.34282048875121 0.355555555555556 12.5 12 5 irregular heartbeat 0.0168145634539636 0.144477466638116 1.34282048875121 0.355555555555556 12.5 12 5 abnormal myocardial trabeculae morphology 0.0168145634539636 0.144477466638116 1.34282048875121 0.355555555555556 12.5 12 5 increased eosinophil cell number 0.00578587820335342 0.06368306208337 1.34011318937873 0.354838709677419 12.5 12 5 absent mature ovarian follicles 0.0441687446407556 0.262218979221669 1.34011318937873 0.354838709677419 12.5 12 5 small cranium 0.0441687446407556 0.262218979221669 1.34011318937873 0.354838709677419 12.5 12 5 preaxial polydactyly 0.0441687446407556 0.262218979221669 1.34011318937873 0.354838709677419 12.5 12 5 weight loss 6.5739447264519e-06 0.000242262037141468 1.33802470129139 0.354285714285714 12.5 12 5 curly tail 0.0145631912647329 0.128822465804225 1.33757509621703 0.354166666666667 12.5 12 5 decreased circulating serum albumin level 0.000645733714045676 0.0114733043834901 1.33519082688331 0.353535353535354 12.5 12 5 abnormal gastrulation 0.0126218028272624 0.117962612268534 1.33294680868687 0.352941176470588 12.5 12 5 small lung 0.0126218028272624 0.117962612268534 1.33294680868687 0.352941176470588 12.5 12 5 enlarged liver sinusoidal spaces 0.0379162963440333 0.25126120331107 1.33294680868687 0.352941176470588 12.5 12 5 lung hemorrhage 0.0379162963440333 0.25126120331107 1.33294680868687 0.352941176470588 12.5 12 5 abnormal adipose tissue morphology 0.125729665605255 0.522124446065229 1.33294680868687 0.352941176470588 12.5 12 5 abnormal interatrial septum morphology 0.125729665605255 0.522124446065229 1.33294680868687 0.352941176470588 12.5 12 5 abnormal duodenum morphology 0.125729665605255 0.522124446065229 1.33294680868687 0.352941176470588 12.5 12 5 abnormal melanosome morphology 0.125729665605255 0.522124446065229 1.33294680868687 0.352941176470588 12.5 12 5 abnormal tarsal bone morphology 0.125729665605255 0.522124446065229 1.33294680868687 0.352941176470588 12.5 12 5 increased circulating magnesium level 0.125729665605255 0.522124446065229 1.33294680868687 0.352941176470588 12.5 12 5 delayed heart development 0.125729665605255 0.522124446065229 1.33294680868687 0.352941176470588 12.5 12 5 abnormal skeletal muscle fiber morphology 0.00382157658506233 0.046713374719128 1.32981782556788 0.352112676056338 12.5 12 5 abnormal liver morphology 7.10657839564446e-06 0.000259964908223023 1.3292234935788 0.35195530726257 12.5 12 5 increased circulating alkaline phosphatase level 1.90665099368649e-05 0.000619973117228123 1.32883277532672 0.351851851851852 12.5 12 5 decreased platelet aggregation 0.0109461388449563 0.104926860797028 1.32883277532672 0.351851851851852 12.5 12 5 abnormal branching of the mammary ductal tree 0.0326012163673837 0.225892829286537 1.32694254378287 0.351351351351351 12.5 12 5 decreased width of hypertrophic chondrocyte zone 0.0326012163673837 0.225892829286537 1.32694254378287 0.351351351351351 12.5 12 5 skin inflammation 0.0326012163673837 0.225892829286537 1.32694254378287 0.351351351351351 12.5 12 5 epidermal hyperplasia 0.0082469583857037 0.0844210246273167 1.32183891861447 0.35 12.5 12 5 absent placental labyrinth 0.105630924024438 0.478562537975361 1.32183891861447 0.35 12.5 12 5 abnormal physiological neovascularization 0.105630924024438 0.478562537975361 1.32183891861447 0.35 12.5 12 5 abnormal sperm mitochondrial sheath morphology 0.105630924024438 0.478562537975361 1.32183891861447 0.35 12.5 12 5 abnormal neuron proliferation 0.105630924024438 0.478562537975361 1.32183891861447 0.35 12.5 12 5 decreased body size 1.39287265891131e-20 8.66192684760473e-18 1.3204191131165 0.349624060150376 12.5 12 5 postnatal lethality 2.05192555498248e-05 0.00065860191200244 1.31956380859965 0.349397590361446 12.5 12 5 abnormal male reproductive system morphology 0.0242011812156182 0.180782096918469 1.31744742719051 0.348837209302326 12.5 12 5 prenatal lethality, incomplete penetrance 1.20962951666165e-08 9.25831822367954e-07 1.31686959937156 0.348684210526316 12.5 12 5 increased bone mineral content 0.000531850317667301 0.0101351090224606 1.31664164894758 0.348623853211009 12.5 12 5 increased startle reflex 0.00167985745285258 0.0246527753036625 1.31547372317973 0.348314606741573 12.5 12 5 abnormal testis morphology 0.00040680465836291 0.00822704542827431 1.31362873899575 0.347826086956522 12.5 12 5 microcephaly 0.00541372426260797 0.0613514309942475 1.31362873899575 0.347826086956522 12.5 12 5 abnormal circulating insulin level 0.0892201264254564 0.426798200929467 1.31362873899575 0.347826086956522 12.5 12 5 failure of embryo implantation 0.0892201264254564 0.426798200929467 1.31362873899575 0.347826086956522 12.5 12 5 abnormal postnatal growth 0.0892201264254564 0.426798200929467 1.31362873899575 0.347826086956522 12.5 12 5 abnormal Wolffian duct morphology 0.0892201264254564 0.426798200929467 1.31362873899575 0.347826086956522 12.5 12 5 kyphosis 6.74991106454523e-05 0.00180541976054368 1.30924997653243 0.346666666666667 12.5 12 5 eyelids open at birth 0.0156080749485518 0.135043778902688 1.30731321621212 0.346153846153846 12.5 12 5 abnormal placenta vasculature 0.0156080749485518 0.135043778902688 1.30731321621212 0.346153846153846 12.5 12 5 abnormal stomach morphology 0.0756774085529203 0.375458887821837 1.30731321621212 0.346153846153846 12.5 12 5 heart inflammation 0.0756774085529203 0.375458887821837 1.30731321621212 0.346153846153846 12.5 12 5 increased leukemia incidence 0.0756774085529203 0.375458887821837 1.30731321621212 0.346153846153846 12.5 12 5 abnormal nerve conduction 0.0756774085529203 0.375458887821837 1.30731321621212 0.346153846153846 12.5 12 5 abnormal dendritic cell physiology 0.000744477482616571 0.0130414629437234 1.30595567393152 0.345794392523364 12.5 12 5 lung inflammation 0.000159779467831049 0.00371449931055827 1.30517708350589 0.345588235294118 12.5 12 5 increased sensitivity to xenobiotic induced morbidity/mortality 0.000650478445370804 0.0115164778139493 1.30467217941169 0.345454545454545 12.5 12 5 increased circulating calcium level 0.0135095493928323 0.122646000418505 1.30467217941169 0.345454545454545 12.5 12 5 decreased circulating calcium level 0.0135095493928323 0.122646000418505 1.30467217941169 0.345454545454545 12.5 12 5 decreased exploration in new environment 0.00270654094828546 0.0352487989992674 1.30385471564013 0.345238095238095 12.5 12 5 abnormal retinal pigmentation 0.00235855598299952 0.0312901760411269 1.30230435331475 0.344827586206897 12.5 12 5 stomach inflammation 0.0644106713174597 0.334081768004696 1.30230435331475 0.344827586206897 12.5 12 5 decreased circulating glucose level 1.18001978263652e-07 7.43113723875529e-06 1.2995036987915 0.344086021505376 12.5 12 5 male infertility 1.36355249499206e-12 2.11989801955797e-10 1.29893855677537 0.343936381709742 12.5 12 5 decreased eosinophil cell number 0.00879893623646163 0.0889729832853589 1.29823465221065 0.34375 12.5 12 5 polydipsia 0.0549775178597856 0.310105613778269 1.29823465221065 0.34375 12.5 12 5 decreased body weight 6.63961380178884e-29 8.25801966597488e-26 1.29651867161586 0.34329563812601 12.5 12 5 decreased body length 1.85541895090659e-07 1.12569625375125e-05 1.2956502434803 0.343065693430657 12.5 12 5 decreased triglyceride level 0.0470388445351547 0.275680013118489 1.29486261415295 0.342857142857143 12.5 12 5 decreased glycogen level 0.0470388445351547 0.275680013118489 1.29486261415295 0.342857142857143 12.5 12 5 increased red blood cell distribution width 0.0470388445351547 0.275680013118489 1.29486261415295 0.342857142857143 12.5 12 5 short snout 0.000906901811927239 0.0152943610655526 1.29386349176549 0.342592592592593 12.5 12 5 abnormal fertility/fecundity 0.00576237717274734 0.0635650253534768 1.29338446048383 0.342465753424658 12.5 12 5 hunched posture 0.00435643972611251 0.0514804932004981 1.29076494765247 0.341772151898734 12.5 12 5 abnormal nervous system morphology 0.00435643972611251 0.0514804932004981 1.29076494765247 0.341772151898734 12.5 12 5 increased tumor growth/size 0.0346390866820938 0.236716286048649 1.28959894498973 0.341463414634146 12.5 12 5 testicular atrophy 0.0221399393188584 0.174835235097334 1.28407209236835 0.34 12.5 12 5 decreased oocyte number 0.0221399393188584 0.174835235097334 1.28407209236835 0.34 12.5 12 5 abnormal seminal vesicle morphology 0.0165231425625788 0.142465570621889 1.28137446192219 0.339285714285714 12.5 12 5 abnormal lipid homeostasis 0.000425909306960931 0.00846128271999467 1.2782618114074 0.338461538461538 12.5 12 5 abnormal cardiovascular system physiology 0.000372212301822362 0.00778048824187499 1.27782494817726 0.338345864661654 12.5 12 5 increased oxygen consumption 0.00399808857765537 0.0482778899850376 1.27353251295082 0.337209302325581 12.5 12 5 abnormal bone structure 2.57981374807505e-05 0.000812314771941353 1.27193974404058 0.336787564766839 12.5 12 5 double outlet right ventricle 0.00152182018631014 0.0229425922027059 1.27065957463608 0.336448598130841 12.5 12 5 thin ventricular wall 0.00419071543176933 0.049997144539694 1.25889420820426 0.333333333333333 12.5 12 5 abnormal kidney physiology 0.0312224722252538 0.217551539664759 1.25889420820426 0.333333333333333 12.5 12 5 abnormal ectoderm development 0.0362900259306425 0.244638047432177 1.25889420820426 0.333333333333333 12.5 12 5 albuminuria 0.0362900259306425 0.244638047432177 1.25889420820426 0.333333333333333 12.5 12 5 acanthosis 0.0492618024573027 0.287649609419109 1.25889420820426 0.333333333333333 12.5 12 5 abnormal heart tube morphology 0.0791612703624422 0.391478449357008 1.25889420820426 0.333333333333333 12.5 12 5 salivary gland inflammation 0.0791612703624422 0.391478449357008 1.25889420820426 0.333333333333333 12.5 12 5 abnormal foregut morphology 0.11030916661856 0.478562537975361 1.25889420820426 0.333333333333333 12.5 12 5 curly vibrissae 0.11030916661856 0.478562537975361 1.25889420820426 0.333333333333333 12.5 12 5 abnormal startle reflex 0.11030916661856 0.478562537975361 1.25889420820426 0.333333333333333 12.5 12 5 increased body temperature 0.11030916661856 0.478562537975361 1.25889420820426 0.333333333333333 12.5 12 5 increased circulating total protein level 0.11030916661856 0.478562537975361 1.25889420820426 0.333333333333333 12.5 12 5 abnormal eye pigmentation 0.131111381084208 0.541310473770901 1.25889420820426 0.333333333333333 12.5 12 5 abnormal anxiety-related response 0.131111381084208 0.541310473770901 1.25889420820426 0.333333333333333 12.5 12 5 trunk curl 0.131111381084208 0.541310473770901 1.25889420820426 0.333333333333333 12.5 12 5 abnormal erythrocyte physiology 0.131111381084208 0.541310473770901 1.25889420820426 0.333333333333333 12.5 12 5 decreased hepatocyte number 0.18913387491535 0.606945107519923 1.25889420820426 0.333333333333333 12.5 12 5 no suckling reflex 0.18913387491535 0.606945107519923 1.25889420820426 0.333333333333333 12.5 12 5 placental labyrinth hypoplasia 0.18913387491535 0.606945107519923 1.25889420820426 0.333333333333333 12.5 12 5 abnormal bronchus morphology 0.18913387491535 0.606945107519923 1.25889420820426 0.333333333333333 12.5 12 5 abnormal glial cell morphology 0.18913387491535 0.606945107519923 1.25889420820426 0.333333333333333 12.5 12 5 abnormal olfactory nerve morphology 0.18913387491535 0.606945107519923 1.25889420820426 0.333333333333333 12.5 12 5 absent chorion 0.18913387491535 0.606945107519923 1.25889420820426 0.333333333333333 12.5 12 5 abnormal secondary palate development 0.18913387491535 0.606945107519923 1.25889420820426 0.333333333333333 12.5 12 5 abnormal branching involved in lung morphogenesis 0.18913387491535 0.606945107519923 1.25889420820426 0.333333333333333 12.5 12 5 decreased brown adipose tissue mass 0.18913387491535 0.606945107519923 1.25889420820426 0.333333333333333 12.5 12 5 abnormal vascular development 0.0129721625047894 0.119956335429976 1.25889420820426 0.333333333333333 12.5 12 5 impaired limb coordination 0.0232023098297898 0.179487020216319 1.25889420820426 0.333333333333333 12.5 12 5 axon degeneration 0.0232023098297898 0.179487020216319 1.25889420820426 0.333333333333333 12.5 12 5 abnormal cervical vertebrae morphology 0.0268990075646565 0.198255648346913 1.25889420820426 0.333333333333333 12.5 12 5 abnormal thrombosis 0.0268990075646565 0.198255648346913 1.25889420820426 0.333333333333333 12.5 12 5 heart right ventricle hypertrophy 0.0575592578871828 0.323933606322098 1.25889420820426 0.333333333333333 12.5 12 5 impaired wound healing 0.0575592578871828 0.323933606322098 1.25889420820426 0.333333333333333 12.5 12 5 abnormal skin appearance 0.0932626504954511 0.445707671676147 1.25889420820426 0.333333333333333 12.5 12 5 abnormal radius morphology 0.156816318275031 0.606945107519923 1.25889420820426 0.333333333333333 12.5 12 5 eye inflammation 0.156816318275031 0.606945107519923 1.25889420820426 0.333333333333333 12.5 12 5 decreased lactate dehydrogenase level 0.156816318275031 0.606945107519923 1.25889420820426 0.333333333333333 12.5 12 5 decreased tumor latency 0.156816318275031 0.606945107519923 1.25889420820426 0.333333333333333 12.5 12 5 primary atelectasis 0.156816318275031 0.606945107519923 1.25889420820426 0.333333333333333 12.5 12 5 increased adipocyte glucose uptake 0.156816318275031 0.606945107519923 1.25889420820426 0.333333333333333 12.5 12 5 postnatal lethality, incomplete penetrance 3.74495689315256e-12 5.32318872669542e-10 1.25667784516165 0.332746478873239 12.5 12 5 ataxia 3.38645309277528e-05 0.00101491591184078 1.2526620586587 0.331683168316832 12.5 12 5 abnormal behavior 1.48741355992774e-06 6.9157780005986e-05 1.24983741533948 0.330935251798561 12.5 12 5 neonatal lethality, incomplete penetrance 3.2753693041437e-06 0.000132479368196056 1.24921040660269 0.330769230769231 12.5 12 5 abnormal myocardial fiber morphology 0.00380190621371829 0.0465873975695776 1.24591591739803 0.329896907216495 12.5 12 5 respiratory distress 0.000152549658466458 0.00359684621265701 1.244340517936 0.329479768786127 12.5 12 5 abnormal heart development 0.000297932463706706 0.0065295771230875 1.24295883848016 0.329113924050633 12.5 12 5 increased insulin sensitivity 0.000583856483405525 0.0107980892377044 1.2412872962014 0.328671328671329 12.5 12 5 perinatal lethality, complete penetrance 3.21579785218232e-05 0.00096961177664285 1.24116330386336 0.328638497652582 12.5 12 5 cleft palate 0.00100315772759686 0.0164709890917306 1.23967444930038 0.32824427480916 12.5 12 5 abnormal long bone morphology 0.0208172877907911 0.167311804134387 1.2382565982337 0.327868852459016 12.5 12 5 reduced female fertility 1.72347657834325e-05 0.00057545610585622 1.23718913564902 0.327586206896552 12.5 12 5 dermatitis 0.0240951965780924 0.180287363034098 1.23718913564902 0.327586206896552 12.5 12 5 abnormal learning/memory/conditioning 0.0279177067991205 0.204250869596506 1.23600522260055 0.327272727272727 12.5 12 5 abnormal joint morphology 0.0279177067991205 0.204250869596506 1.23600522260055 0.327272727272727 12.5 12 5 decreased circulating creatinine level 0.037610148304965 0.25081834828043 1.23320248966948 0.326530612244898 12.5 12 5 decreased birth weight 0.00520670661851325 0.0592754357599621 1.23239117224207 0.326315789473684 12.5 12 5 abnormal immune system morphology 0.0437423528170549 0.261099165220573 1.23152694280852 0.326086956521739 12.5 12 5 reduced male fertility 2.6543827789565e-05 0.000825347145331788 1.23116526088699 0.325991189427313 12.5 12 5 abnormal left-right axis patterning 0.0509552396804817 0.296841121089457 1.22961759871114 0.325581395348837 12.5 12 5 delayed endochondral bone ossification 0.0509552396804817 0.296841121089457 1.22961759871114 0.325581395348837 12.5 12 5 abnormal retinal pigment epithelium morphology 0.0104990215552091 0.101030236435522 1.22742185299915 0.325 12.5 12 5 abnormal female reproductive system morphology 0.0594647292652211 0.331521444703892 1.22742185299915 0.325 12.5 12 5 abnormal enzyme/coenzyme activity 0.000478704267135633 0.00924206464554004 1.22682047041562 0.32484076433121 12.5 12 5 respiratory failure 0.000626298942080145 0.0112080476145637 1.22554601725845 0.324503311258278 12.5 12 5 abnormal axon morphology 0.00355105701993485 0.0447253384156351 1.22392492464303 0.324074074074074 12.5 12 5 abnormal immune system physiology 0.00211654334975454 0.029141896680057 1.21828471761703 0.32258064516129 12.5 12 5 osteopetrosis 0.0958243778489594 0.455716547688271 1.21828471761703 0.32258064516129 12.5 12 5 abnormal postnatal growth/weight/body size 0.0958243778489594 0.455716547688271 1.21828471761703 0.32258064516129 12.5 12 5 abnormal capillary morphology 0.0958243778489594 0.455716547688271 1.21828471761703 0.32258064516129 12.5 12 5 abnormal skeleton morphology 0.0031882916641801 0.0407757095868791 1.21510658357107 0.321739130434783 12.5 12 5 increased rib number 0.014342832978451 0.128800711313707 1.21047520019641 0.320512820512821 12.5 12 5 ruffled hair 0.133851605407372 0.547637402333455 1.20853843987609 0.32 12.5 12 5 mandible hypoplasia 0.133851605407372 0.547637402333455 1.20853843987609 0.32 12.5 12 5 abnormal thyroid gland morphology 0.133851605407372 0.547637402333455 1.20853843987609 0.32 12.5 12 5 abnormal primitive streak morphology 0.133851605407372 0.547637402333455 1.20853843987609 0.32 12.5 12 5 abnormal vertebrae development 0.133851605407372 0.547637402333455 1.20853843987609 0.32 12.5 12 5 abnormal preimplantation embryo development 0.133851605407372 0.547637402333455 1.20853843987609 0.32 12.5 12 5 increased circulating glucose level 0.00148800493952765 0.0226720881064829 1.2053242418977 0.319148936170213 12.5 12 5 increased respiratory quotient 0.052214059494543 0.302756347302275 1.2053242418977 0.319148936170213 12.5 12 5 abnormal sternum morphology 0.022023302896917 0.174468044446118 1.20415967741277 0.318840579710145 12.5 12 5 small ovary 0.00963284363710494 0.0932361811178932 1.20355819905243 0.318681318681319 12.5 12 5 abnormal skin morphology 0.0254441061457137 0.18978175123677 1.20167174419498 0.318181818181818 12.5 12 5 osteoporosis 0.0608285224823346 0.334081768004696 1.20167174419498 0.318181818181818 12.5 12 5 abnormal circadian rhythm 0.0608285224823346 0.334081768004696 1.20167174419498 0.318181818181818 12.5 12 5 abnormal abdominal fat pad morphology 0.15931868220805 0.606945107519923 1.20167174419498 0.318181818181818 12.5 12 5 increased myocardial infarction size 0.15931868220805 0.606945107519923 1.20167174419498 0.318181818181818 12.5 12 5 increased coping response 0.15931868220805 0.606945107519923 1.20167174419498 0.318181818181818 12.5 12 5 abnormal basement membrane morphology 0.15931868220805 0.606945107519923 1.20167174419498 0.318181818181818 12.5 12 5 cardiac fibrosis 0.0127490150029957 0.118112382942093 1.19965212781818 0.317647058823529 12.5 12 5 decreased susceptibility to hepatic steatosis 0.0294204439799804 0.214929087812632 1.19894686495644 0.317460317460317 12.5 12 5 decreased bone mineral content 0.000170483966518937 0.00390856098355626 1.19837044819444 0.317307692307692 12.5 12 5 increased heart weight 0.00199410117850766 0.027867003828864 1.19549665815081 0.316546762589928 12.5 12 5 decreased hair follicle number 0.0830204611746381 0.405588086970623 1.19263661829877 0.315789473684211 12.5 12 5 decreased total retina thickness 0.0830204611746381 0.405588086970623 1.19263661829877 0.315789473684211 12.5 12 5 small superior vagus ganglion 0.190851131367744 0.606945107519923 1.19263661829877 0.315789473684211 12.5 12 5 shiny skin 0.190851131367744 0.606945107519923 1.19263661829877 0.315789473684211 12.5 12 5 thin dermal layer 0.190851131367744 0.606945107519923 1.19263661829877 0.315789473684211 12.5 12 5 abnormal neural crest cell migration 0.190851131367744 0.606945107519923 1.19263661829877 0.315789473684211 12.5 12 5 abnormal digestive system development 0.190851131367744 0.606945107519923 1.19263661829877 0.315789473684211 12.5 12 5 maternal imprinting 0.190851131367744 0.606945107519923 1.19263661829877 0.315789473684211 12.5 12 5 oliguria 0.190851131367744 0.606945107519923 1.19263661829877 0.315789473684211 12.5 12 5 abnormal cochlear inner hair cell morphology 0.190851131367744 0.606945107519923 1.19263661829877 0.315789473684211 12.5 12 5 decreased fertilization frequency 0.190851131367744 0.606945107519923 1.19263661829877 0.315789473684211 12.5 12 5 absent vitelline blood vessels 0.0394442210625016 0.25126120331107 1.19263661829877 0.315789473684211 12.5 12 5 abnormal facial morphology 0.0394442210625016 0.25126120331107 1.19263661829877 0.315789473684211 12.5 12 5 abnormal circulating amino acid level 0.0394442210625016 0.25126120331107 1.19263661829877 0.315789473684211 12.5 12 5 increased macrophage cell number 0.0394442210625016 0.25126120331107 1.19263661829877 0.315789473684211 12.5 12 5 abnormal cell adhesion 0.0457443698652491 0.271249392228384 1.1889556410818 0.314814814814815 12.5 12 5 impaired glucose tolerance 6.50615522005357e-05 0.00174962822809549 1.1878275996766 0.314516129032258 12.5 12 5 abnormal dermal layer morphology 0.0973175482563341 0.455716547688271 1.18695739630688 0.314285714285714 12.5 12 5 cataract 0.00448753709824158 0.0527789528693898 1.18606561764699 0.31404958677686 12.5 12 5 abnormal bone mineralization 0.00448753709824158 0.0527789528693898 1.18606561764699 0.31404958677686 12.5 12 5 increased total body fat amount 0.00304583182542793 0.0391183037514085 1.18373634502789 0.313432835820896 12.5 12 5 abnormal motor coordination/ balance 0.010023366088345 0.0968276626980901 1.18259758952522 0.313131313131313 12.5 12 5 decreased circulating LDL cholesterol level 0.0346106631713951 0.236716286048649 1.1802133201915 0.3125 12.5 12 5 abnormal extraembryonic endoderm formation 0.230568177195811 0.635459042162047 1.1802133201915 0.3125 12.5 12 5 decreased circulating prolactin level 0.230568177195811 0.635459042162047 1.1802133201915 0.3125 12.5 12 5 kidney degeneration 0.230568177195811 0.635459042162047 1.1802133201915 0.3125 12.5 12 5 increased heart left ventricle size 0.230568177195811 0.635459042162047 1.1802133201915 0.3125 12.5 12 5 abnormal intestinal epithelium morphology 0.0617556900714928 0.334081768004696 1.1802133201915 0.3125 12.5 12 5 no abnormal phenotype detected 3.23593688185037e-25 2.6831309978676e-22 1.17980517725656 0.312391930835735 12.5 12 5 lethargy 0.0132209182866711 0.122029811644135 1.17767522702979 0.311827956989247 12.5 12 5 increased osteoclast cell number 0.0400344934689311 0.254695147068967 1.17634376832202 0.311475409836066 12.5 12 5 trabecula carnea hypoplasia 0.0719104241508407 0.36100339066643 1.17496792765731 0.311111111111111 12.5 12 5 cardiomyopathy 0.0719104241508407 0.36100339066643 1.17496792765731 0.311111111111111 12.5 12 5 insulin resistance 0.00404979500042799 0.0486660147998291 1.17306051219033 0.310606060606061 12.5 12 5 decreased retinal photoreceptor cell number 0.134898695373526 0.548749803338749 1.17207391798328 0.310344827586207 12.5 12 5 enlarged epididymis 0.134898695373526 0.548749803338749 1.17207391798328 0.310344827586207 12.5 12 5 increased circulating triglyceride level 0.00274985450403868 0.0357193894454111 1.17207391798328 0.310344827586207 12.5 12 5 increased sensitivity to induced morbidity/mortality 0.000873069309701404 0.0148242997125068 1.16995059566809 0.309782608695652 12.5 12 5 abnormal retina morphology 0.0004098026305429 0.00825412180951793 1.16897319333253 0.30952380952381 12.5 12 5 increased food intake 0.0200855058785064 0.164081103030491 1.16897319333253 0.30952380952381 12.5 12 5 abnormal optic nerve morphology 0.083877194882243 0.407907179412668 1.16897319333253 0.30952380952381 12.5 12 5 abnormal pancreas morphology 0.083877194882243 0.407907179412668 1.16897319333253 0.30952380952381 12.5 12 5 postnatal lethality, complete penetrance 2.89356357340109e-06 0.000119962323147254 1.16431407339099 0.308290155440414 12.5 12 5 decreased bone mineral density 9.26719128074674e-05 0.00239472054884157 1.16424050833928 0.308270676691729 12.5 12 5 hypoactivity 4.23788682405892e-06 0.000167329261505501 1.16205619218855 0.307692307692308 12.5 12 5 impaired macrophage chemotaxis 0.0980243094934538 0.455716547688271 1.16205619218855 0.307692307692308 12.5 12 5 small seminal vesicle 0.15970680400935 0.606945107519923 1.16205619218855 0.307692307692308 12.5 12 5 hyperactivity 5.46419174007997e-06 0.000209110414668445 1.16049007872199 0.307277628032345 12.5 12 5 decreased litter size 8.42886565925094e-05 0.0022070319291986 1.15585304525516 0.306049822064057 12.5 12 5 decreased grip strength 0.000483002373435259 0.00924206464554004 1.15542345136556 0.305936073059361 12.5 12 5 alopecia 0.0178148026178346 0.151243418129228 1.15288206435548 0.305263157894737 12.5 12 5 abnormal sleep pattern 0.0842339553593718 0.408444374184089 1.14942514662128 0.304347826086957 12.5 12 5 abnormal nasal cavity morphology 0.189986800362935 0.606945107519923 1.14942514662128 0.304347826086957 12.5 12 5 abnormal cardiovascular development 0.189986800362935 0.606945107519923 1.14942514662128 0.304347826086957 12.5 12 5 abnormal ulna morphology 0.189986800362935 0.606945107519923 1.14942514662128 0.304347826086957 12.5 12 5 abnormal chondrocyte physiology 0.189986800362935 0.606945107519923 1.14942514662128 0.304347826086957 12.5 12 5 abnormal hepatocyte physiology 0.189986800362935 0.606945107519923 1.14942514662128 0.304347826086957 12.5 12 5 decreased effector memory CD8-positive, alpha-beta T cell number 0.189986800362935 0.606945107519923 1.14942514662128 0.304347826086957 12.5 12 5 belly spot 0.13481771592846 0.548749803338749 1.14444928018569 0.303030303030303 12.5 12 5 abnormal epidermis stratum basale morphology 0.13481771592846 0.548749803338749 1.14444928018569 0.303030303030303 12.5 12 5 abnormal skeleton physiology 0.13481771592846 0.548749803338749 1.14444928018569 0.303030303030303 12.5 12 5 decreased sensitivity to xenobiotic induced morbidity/mortality 0.13481771592846 0.548749803338749 1.14444928018569 0.303030303030303 12.5 12 5 abnormal blood circulation 0.0981433754696728 0.455716547688271 1.14178777023177 0.302325581395349 12.5 12 5 skin lesions 0.0542328133207253 0.307298685957413 1.13899952170862 0.301587301587302 12.5 12 5 female infertility 0.000269744127999431 0.00599096891427308 1.13584439837979 0.300751879699248 12.5 12 5 domed cranium 0.047045214813942 0.275680013118489 1.13300478738384 0.3 12.5 12 5 decreased circulating alkaline phosphatase level 0.0842015156758284 0.408444374184089 1.13300478738384 0.3 12.5 12 5 abnormal circulating protein level 0.0842015156758284 0.408444374184089 1.13300478738384 0.3 12.5 12 5 enhanced paired-pulse facilitation 0.158786163235418 0.606945107519923 1.13300478738384 0.3 12.5 12 5 abnormal microglial cell physiology 0.158786163235418 0.606945107519923 1.13300478738384 0.3 12.5 12 5 increased circulating insulin level 0.00428809620679451 0.050914746130794 1.13300478738384 0.3 12.5 12 5 decreased circulating phosphate level 0.114549843876982 0.482953790922022 1.13300478738384 0.3 12.5 12 5 increased susceptibility to weight loss 0.114549843876982 0.482953790922022 1.13300478738384 0.3 12.5 12 5 anencephaly 0.227374077372019 0.631947505545135 1.13300478738384 0.3 12.5 12 5 abnormal dopamine level 0.227374077372019 0.631947505545135 1.13300478738384 0.3 12.5 12 5 kidney atrophy 0.227374077372019 0.631947505545135 1.13300478738384 0.3 12.5 12 5 abnormal circulating cytokine level 0.227374077372019 0.631947505545135 1.13300478738384 0.3 12.5 12 5 absent ductus venosus valve 0.227374077372019 0.631947505545135 1.13300478738384 0.3 12.5 12 5 infertility 0.018030711561344 0.152407306125623 1.12947517745429 0.299065420560748 12.5 12 5 maternal effect 0.0542166648669857 0.307298685957413 1.12736794764561 0.298507462686567 12.5 12 5 neonatal lethality, complete penetrance 4.22146438815425e-06 0.000167329261505501 1.12637902839329 0.298245614035088 12.5 12 5 pulmonary hypoplasia 0.0978181536050571 0.455716547688271 1.12496929243785 0.297872340425532 12.5 12 5 increased white adipose tissue amount 0.133964767565792 0.547637402333455 1.12279753704704 0.297297297297297 12.5 12 5 increased circulating phosphate level 0.133964767565792 0.547637402333455 1.12279753704704 0.297297297297297 12.5 12 5 increased trabecular bone volume 0.133964767565792 0.547637402333455 1.12279753704704 0.297297297297297 12.5 12 5 abnormal kidney morphology 0.00378980720025321 0.0465538044969376 1.12221426559923 0.297142857142857 12.5 12 5 abnormal neuronal precursor proliferation 0.0838640659555618 0.407907179412668 1.11901707395934 0.296296296296296 12.5 12 5 rectal prolapse 0.187683289699413 0.606945107519923 1.11901707395934 0.296296296296296 12.5 12 5 abnormal trigeminal ganglion morphology 0.187683289699413 0.606945107519923 1.11901707395934 0.296296296296296 12.5 12 5 increased brain weight 0.187683289699413 0.606945107519923 1.11901707395934 0.296296296296296 12.5 12 5 abnormal type II pneumocyte morphology 0.187683289699413 0.606945107519923 1.11901707395934 0.296296296296296 12.5 12 5 polydactyly 0.0269793202235135 0.198553429159733 1.11758975626297 0.295918367346939 12.5 12 5 corneal opacity 0.054057998378647 0.307007467960923 1.11704697347702 0.295774647887324 12.5 12 5 decreased liver weight 0.054057998378647 0.307007467960923 1.11704697347702 0.295774647887324 12.5 12 5 hydroencephaly 0.018012574263786 0.152407306125623 1.11658442814639 0.295652173913043 12.5 12 5 abnormal astrocyte morphology 0.113791539625653 0.480571230592211 1.11583804818105 0.295454545454545 12.5 12 5 abnormal amino acid level 0.113791539625653 0.480571230592211 1.11583804818105 0.295454545454545 12.5 12 5 abnormal heart ventricle morphology 0.0468319620986937 0.275680013118489 1.11363718418069 0.294871794871795 12.5 12 5 short maxilla 0.157026901755334 0.606945107519923 1.11078900723905 0.294117647058824 12.5 12 5 decreased osteoblast cell number 0.157026901755334 0.606945107519923 1.11078900723905 0.294117647058824 12.5 12 5 increased susceptibility to viral infection induced morbidity/mortality 0.157026901755334 0.606945107519923 1.11078900723905 0.294117647058824 12.5 12 5 distended urinary bladder 0.274250890358543 0.723839309383726 1.11078900723905 0.294117647058824 12.5 12 5 abnormal glutamate-mediated receptor currents 0.274250890358543 0.723839309383726 1.11078900723905 0.294117647058824 12.5 12 5 aminoaciduria 0.274250890358543 0.723839309383726 1.11078900723905 0.294117647058824 12.5 12 5 abnormal testis development 0.274250890358543 0.723839309383726 1.11078900723905 0.294117647058824 12.5 12 5 common atrium 0.274250890358543 0.723839309383726 1.11078900723905 0.294117647058824 12.5 12 5 abnormal electroretinogram waveform feature 0.274250890358543 0.723839309383726 1.11078900723905 0.294117647058824 12.5 12 5 abnormal ductus venosus valve morphology 0.274250890358543 0.723839309383726 1.11078900723905 0.294117647058824 12.5 12 5 glomerulosclerosis 0.0832864927614217 0.40622578577262 1.10695870031754 0.293103448275862 12.5 12 5 abnormal mammary gland development 0.132574225978687 0.546443060682656 1.10537052427691 0.292682926829268 12.5 12 5 lethality at weaning, incomplete penetrance 0.132574225978687 0.546443060682656 1.10537052427691 0.292682926829268 12.5 12 5 cyanosis 0.00425488715764803 0.0506413005007152 1.10153243217873 0.291666666666667 12.5 12 5 abnormal neuromuscular synapse morphology 0.0617787976782683 0.334081768004696 1.10153243217873 0.291666666666667 12.5 12 5 abnormal heart left ventricle morphology 0.0617787976782683 0.334081768004696 1.10153243217873 0.291666666666667 12.5 12 5 abnormal osteoclast morphology 0.112667403295348 0.478562537975361 1.10153243217873 0.291666666666667 12.5 12 5 abnormal digestive system morphology 0.22279523778709 0.624668028176135 1.10153243217873 0.291666666666667 12.5 12 5 abnormal nursing 0.22279523778709 0.624668028176135 1.10153243217873 0.291666666666667 12.5 12 5 abnormal vasodilation 0.22279523778709 0.624668028176135 1.10153243217873 0.291666666666667 12.5 12 5 blindness 0.22279523778709 0.624668028176135 1.10153243217873 0.291666666666667 12.5 12 5 prolonged QT interval 0.22279523778709 0.624668028176135 1.10153243217873 0.291666666666667 12.5 12 5 decreased fatty acid level 0.22279523778709 0.624668028176135 1.10153243217873 0.291666666666667 12.5 12 5 hypopigmentation 0.22279523778709 0.624668028176135 1.10153243217873 0.291666666666667 12.5 12 5 abnormal cellular extravasation 0.22279523778709 0.624668028176135 1.10153243217873 0.291666666666667 12.5 12 5 abnormal truncus arteriosus septation 0.22279523778709 0.624668028176135 1.10153243217873 0.291666666666667 12.5 12 5 abnormal lung saccule morphology 0.22279523778709 0.624668028176135 1.10153243217873 0.291666666666667 12.5 12 5 hypoglycemia 0.040129206191384 0.254971648534017 1.09645624585532 0.290322580645161 12.5 12 5 abnormal cranial ganglia morphology 0.184543257257151 0.606945107519923 1.09645624585532 0.290322580645161 12.5 12 5 abnormal eyelid morphology 0.184543257257151 0.606945107519923 1.09645624585532 0.290322580645161 12.5 12 5 decreased heart rate 0.0348680492440981 0.237260422550259 1.09523796113771 0.29 12.5 12 5 seizures 0.0264249073192283 0.196802266337067 1.09325023344054 0.289473684210526 12.5 12 5 abnormal frontal bone morphology 0.15471985535478 0.606945107519923 1.09325023344054 0.289473684210526 12.5 12 5 persistence of hyaloid vascular system 0.15471985535478 0.606945107519923 1.09325023344054 0.289473684210526 12.5 12 5 abnormal retinal outer nuclear layer morphology 0.15471985535478 0.606945107519923 1.09325023344054 0.289473684210526 12.5 12 5 decreased insulin secretion 0.0458602213282266 0.27161262036658 1.09104164711036 0.288888888888889 12.5 12 5 increased circulating corticosterone level 0.130805742787296 0.541310473770901 1.09104164711036 0.288888888888889 12.5 12 5 abnormal skin condition 0.111272727560665 0.478562537975361 1.08942768017677 0.288461538461538 12.5 12 5 increased hemoglobin content 0.0951088232861966 0.45409442979734 1.08819668844775 0.288135593220339 12.5 12 5 abnormal motor capabilities/coordination/movement 0.0199495063524684 0.16359908838805 1.08722681617641 0.287878787878788 12.5 12 5 microphthalmia 0.0133293668204501 0.122646000418505 1.08610480707819 0.287581699346405 12.5 12 5 impaired coordination 0.000412130804187402 0.00826754335013035 1.08061150241811 0.286127167630058 12.5 12 5 increased circulating LDL cholesterol level 0.128771110626092 0.533863562804004 1.0790521784608 0.285714285714286 12.5 12 5 abnormal craniofacial development 0.128771110626092 0.533863562804004 1.0790521784608 0.285714285714286 12.5 12 5 spina bifida 0.152053038417264 0.60662699769518 1.0790521784608 0.285714285714286 12.5 12 5 increased circulating luteinizing hormone level 0.217547364898797 0.624668028176135 1.0790521784608 0.285714285714286 12.5 12 5 abnormal ovulation 0.217547364898797 0.624668028176135 1.0790521784608 0.285714285714286 12.5 12 5 straub tail 0.217547364898797 0.624668028176135 1.0790521784608 0.285714285714286 12.5 12 5 abnormal retinal inner nuclear layer morphology 0.217547364898797 0.624668028176135 1.0790521784608 0.285714285714286 12.5 12 5 hypoxia 0.217547364898797 0.624668028176135 1.0790521784608 0.285714285714286 12.5 12 5 decreased circulating progesterone level 0.217547364898797 0.624668028176135 1.0790521784608 0.285714285714286 12.5 12 5 prolonged QRS complex duration 0.217547364898797 0.624668028176135 1.0790521784608 0.285714285714286 12.5 12 5 small ears 0.265879155887143 0.721630551303075 1.0790521784608 0.285714285714286 12.5 12 5 abnormal embryonic/fetal subventricular zone morphology 0.265879155887143 0.721630551303075 1.0790521784608 0.285714285714286 12.5 12 5 increased keratinocyte proliferation 0.265879155887143 0.721630551303075 1.0790521784608 0.285714285714286 12.5 12 5 vascular ring 0.265879155887143 0.721630551303075 1.0790521784608 0.285714285714286 12.5 12 5 increased bone ossification 0.265879155887143 0.721630551303075 1.0790521784608 0.285714285714286 12.5 12 5 abnormal gait 0.000970805796898568 0.0159925789389748 1.07556010021335 0.284789644012945 12.5 12 5 abnormal suckling behavior 0.0591376318951913 0.331521444703892 1.07292120017409 0.284090909090909 12.5 12 5 increased exploration in new environment 0.0684606332214665 0.349683419175355 1.07239136254437 0.283950617283951 12.5 12 5 abnormal eating behavior 0.10793644505097 0.478562537975361 1.07006007697362 0.283333333333333 12.5 12 5 abnormal locomotor behavior 0.0583266328905467 0.327881354384712 1.06732335043405 0.282608695652174 12.5 12 5 abnormal cornea morphology 0.0782432427541921 0.387709295520026 1.06521817617284 0.282051282051282 12.5 12 5 abnormal heart looping 0.176993105514587 0.606945107519923 1.06521817617284 0.282051282051282 12.5 12 5 abnormal lens morphology 0.0322609561470407 0.224473086477661 1.06219198817235 0.28125 12.5 12 5 abnormal crypts of Lieberkuhn morphology 0.211994088727104 0.613180576405433 1.06219198817235 0.28125 12.5 12 5 bradykinesia 0.211994088727104 0.613180576405433 1.06219198817235 0.28125 12.5 12 5 abnormal craniofacial bone morphology 0.124201925604193 0.518811570009117 1.0601214384878 0.280701754385965 12.5 12 5 abnormal glucose homeostasis 0.0137864526311888 0.124217540408097 1.05830117502886 0.28021978021978 12.5 12 5 increased body length 0.146103730884527 0.585238374517328 1.05747113489158 0.28 12.5 12 5 abnormal feces composition 0.25738442815698 0.701637002784096 1.05747113489158 0.28 12.5 12 5 abnormal cochlear outer hair cell morphology 0.25738442815698 0.701637002784096 1.05747113489158 0.28 12.5 12 5 decreased acute inflammation 0.25738442815698 0.701637002784096 1.05747113489158 0.28 12.5 12 5 increased circulating creatinine level 0.0756955305498095 0.375458887821837 1.05395794175241 0.27906976744186 12.5 12 5 impaired macrophage phagocytosis 0.172921295042138 0.606945107519923 1.05395794175241 0.27906976744186 12.5 12 5 abnormal nervous system physiology 0.0475513660805261 0.277988303467236 1.0509029911966 0.278260869565217 12.5 12 5 diluted coat color 0.142968193199475 0.573602226747894 1.04907850683688 0.277777777777778 12.5 12 5 narrow eye opening 0.206333507438078 0.606945107519923 1.04907850683688 0.277777777777778 12.5 12 5 underdeveloped hair follicles 0.319418033467585 0.791603483042952 1.04907850683688 0.277777777777778 12.5 12 5 acidosis 0.319418033467585 0.791603483042952 1.04907850683688 0.277777777777778 12.5 12 5 absent allantois 0.319418033467585 0.791603483042952 1.04907850683688 0.277777777777778 12.5 12 5 absent ureter 0.319418033467585 0.791603483042952 1.04907850683688 0.277777777777778 12.5 12 5 atrioventricular block 0.319418033467585 0.791603483042952 1.04907850683688 0.277777777777778 12.5 12 5 decreased monocyte cell number 0.119283808249185 0.499105926021612 1.04585057296969 0.276923076923077 12.5 12 5 decreased bone trabecula number 0.168779929844018 0.606945107519923 1.044614342978 0.276595744680851 12.5 12 5 abnormal cranium morphology 0.0393492596152335 0.25126120331107 1.04281535157219 0.276119402985075 12.5 12 5 increased blood urea nitrogen level 0.0337323962926181 0.231155194980407 1.0418434826518 0.275862068965517 12.5 12 5 abnormal parietal bone morphology 0.249032572336995 0.681858584136793 1.0418434826518 0.275862068965517 12.5 12 5 abnormal microglial cell morphology 0.249032572336995 0.681858584136793 1.0418434826518 0.275862068965517 12.5 12 5 abnormal circulating glucose level 0.249032572336995 0.681858584136793 1.0418434826518 0.275862068965517 12.5 12 5 aphagia 0.249032572336995 0.681858584136793 1.0418434826518 0.275862068965517 12.5 12 5 absent long term depression 0.249032572336995 0.681858584136793 1.0418434826518 0.275862068965517 12.5 12 5 abnormal outer ear morphology 0.249032572336995 0.681858584136793 1.0418434826518 0.275862068965517 12.5 12 5 abnormal renal glomerulus morphology 0.0609351794833845 0.334081768004696 1.03945393337967 0.275229357798165 12.5 12 5 perinatal lethality 0.200678480618507 0.606945107519923 1.03858772176852 0.275 12.5 12 5 increased thermal nociceptive threshold 0.0829118459233323 0.405588086970623 1.03755017159692 0.274725274725275 12.5 12 5 impaired balance 0.0703037673444375 0.355479416422189 1.03673640675645 0.274509803921569 12.5 12 5 abnormal gluconeogenesis 0.164625133979401 0.606945107519923 1.03673640675645 0.274509803921569 12.5 12 5 cochlear inner hair cell degeneration 0.164625133979401 0.606945107519923 1.03673640675645 0.274509803921569 12.5 12 5 decreased startle reflex 0.0586656694888553 0.329415017728053 1.03293883750093 0.273504273504274 12.5 12 5 reduced fertility 0.0427928439638737 0.261099165220573 1.03247438658479 0.273381294964029 12.5 12 5 increased or absent threshold for auditory brainstem response 0.00548790589023249 0.0619274442283842 1.03238037143394 0.273356401384083 12.5 12 5 increased circulating cholesterol level 0.0265370429135264 0.197188815807872 1.03000435216712 0.272727272727273 12.5 12 5 abnormal neuron morphology 0.0796014222938532 0.393264226327626 1.03000435216712 0.272727272727273 12.5 12 5 omphalocele 0.195094953323319 0.606945107519923 1.03000435216712 0.272727272727273 12.5 12 5 decreased macrophage cell number 0.195094953323319 0.606945107519923 1.03000435216712 0.272727272727273 12.5 12 5 abnormal basisphenoid bone morphology 0.305839333516802 0.763830664782175 1.03000435216712 0.272727272727273 12.5 12 5 abnormal tail movements 0.305839333516802 0.763830664782175 1.03000435216712 0.272727272727273 12.5 12 5 testis hypoplasia 0.305839333516802 0.763830664782175 1.03000435216712 0.272727272727273 12.5 12 5 abnormal female reproductive system physiology 0.305839333516802 0.763830664782175 1.03000435216712 0.272727272727273 12.5 12 5 prolonged PR interval 0.305839333516802 0.763830664782175 1.03000435216712 0.272727272727273 12.5 12 5 abnormal blood-brain barrier function 0.305839333516802 0.763830664782175 1.03000435216712 0.272727272727273 12.5 12 5 failure of palatal shelf elevation 0.305839333516802 0.763830664782175 1.03000435216712 0.272727272727273 12.5 12 5 increased circulating creatine kinase level 0.305839333516802 0.763830664782175 1.03000435216712 0.272727272727273 12.5 12 5 increased bone volume 0.305839333516802 0.763830664782175 1.03000435216712 0.272727272727273 12.5 12 5 oligodactyly 0.189621725419238 0.606945107519923 1.02285154416596 0.270833333333333 12.5 12 5 abnormal long bone metaphysis morphology 0.233136744427813 0.641512889119674 1.02072503367913 0.27027027027027 12.5 12 5 abnormal hair follicle morphology 0.152400075883485 0.606945107519923 1.01910483521297 0.26984126984127 12.5 12 5 increased circulating aspartate transaminase level 0.152400075883485 0.606945107519923 1.01910483521297 0.26984126984127 12.5 12 5 increased urine protein level 0.12407033982035 0.518697429080875 1.01679916816498 0.269230769230769 12.5 12 5 ventricular hypoplasia 0.293370921264001 0.73750395820536 1.01679916816498 0.269230769230769 12.5 12 5 thick skin 0.293370921264001 0.73750395820536 1.01679916816498 0.269230769230769 12.5 12 5 no spontaneous movement 0.293370921264001 0.73750395820536 1.01679916816498 0.269230769230769 12.5 12 5 abnormal erythrocyte osmotic lysis 0.293370921264001 0.73750395820536 1.01679916816498 0.269230769230769 12.5 12 5 abnormal Mullerian duct morphology 0.293370921264001 0.73750395820536 1.01679916816498 0.269230769230769 12.5 12 5 decreased bone resorption 0.293370921264001 0.73750395820536 1.01679916816498 0.269230769230769 12.5 12 5 decreased anxiety-related response 0.0699768496580591 0.355479416422189 1.0132563139205 0.268292682926829 12.5 12 5 reduced long term potentiation 0.0823411481198961 0.405588086970623 1.011611417307 0.267857142857143 12.5 12 5 abnormal neuron differentiation 0.0823411481198961 0.405588086970623 1.011611417307 0.267857142857143 12.5 12 5 abnormal eye development 0.179086028756685 0.606945107519923 1.011611417307 0.267857142857143 12.5 12 5 atelectasis 0.144615513941422 0.579743901578225 1.01066154743159 0.267605633802817 12.5 12 5 abnormal kidney development 0.174041995670412 0.606945107519923 1.00711536656341 0.266666666666667 12.5 12 5 small placenta 0.218472848063691 0.624668028176135 1.00711536656341 0.266666666666667 12.5 12 5 delayed eyelid opening 0.281849448373933 0.723839309383726 1.00711536656341 0.266666666666667 12.5 12 5 emphysema 0.281849448373933 0.723839309383726 1.00711536656341 0.266666666666667 12.5 12 5 decreased circulating HDL cholesterol level 0.0751001394753474 0.374371937765384 1.00318132216277 0.265625 12.5 12 5 abnormal long bone hypertrophic chondrocyte zone 0.211595558538986 0.61274033977384 1.00197702285645 0.26530612244898 12.5 12 5 abnormal lipid level 0.133620634816792 0.547637402333455 1.00104840652387 0.265060240963855 12.5 12 5 abnormal retinal photoreceptor morphology 0.271142226164251 0.723839309383726 0.999710106515149 0.264705882352941 12.5 12 5 abnormal oocyte morphology 0.271142226164251 0.723839309383726 0.999710106515149 0.264705882352941 12.5 12 5 overexpanded pulmonary alveoli 0.271142226164251 0.723839309383726 0.999710106515149 0.264705882352941 12.5 12 5 abnormal nervous system development 0.271142226164251 0.723839309383726 0.999710106515149 0.264705882352941 12.5 12 5 increased susceptibility to weight gain 0.271142226164251 0.723839309383726 0.999710106515149 0.264705882352941 12.5 12 5 cochlear outer hair cell degeneration 0.159824716629287 0.606945107519923 0.99662458149504 0.263888888888889 12.5 12 5 abnormal blood homeostasis 0.0991559341702392 0.458457967004591 0.993863848582312 0.263157894736842 12.5 12 5 abnormal axial skeleton morphology 0.155383399024501 0.606945107519923 0.993863848582312 0.263157894736842 12.5 12 5 abnormal triglyceride level 0.365334784217528 0.791603483042952 0.993863848582312 0.263157894736842 12.5 12 5 abnormal stationary movement 0.365334784217528 0.791603483042952 0.993863848582312 0.263157894736842 12.5 12 5 delayed sexual maturation 0.365334784217528 0.791603483042952 0.993863848582312 0.263157894736842 12.5 12 5 decreased germ cell number 0.365334784217528 0.791603483042952 0.993863848582312 0.263157894736842 12.5 12 5 abnormal sternebra morphology 0.365334784217528 0.791603483042952 0.993863848582312 0.263157894736842 12.5 12 5 absent amnion 0.365334784217528 0.791603483042952 0.993863848582312 0.263157894736842 12.5 12 5 decreased susceptibility to weight gain 0.365334784217528 0.791603483042952 0.993863848582312 0.263157894736842 12.5 12 5 decreased liver glycogen level 0.365334784217528 0.791603483042952 0.993863848582312 0.263157894736842 12.5 12 5 abnormal posture 0.151084830439396 0.603248018808986 0.991379188960856 0.2625 12.5 12 5 abnormal maternal nurturing 0.192627967631326 0.606945107519923 0.99060527858696 0.262295081967213 12.5 12 5 abnormal cartilage morphology 0.2517651059626 0.688204067123042 0.989131163589063 0.261904761904762 12.5 12 5 abnormal vibrissa morphology 0.2517651059626 0.688204067123042 0.989131163589063 0.261904761904762 12.5 12 5 increased liver weight 0.142898039388032 0.573602226747894 0.98708750416016 0.261363636363636 12.5 12 5 abnormal pulmonary artery morphology 0.346728462865227 0.791603483042952 0.985221554246814 0.260869565217391 12.5 12 5 abnormal cochlear ganglion morphology 0.346728462865227 0.791603483042952 0.985221554246814 0.260869565217391 12.5 12 5 decreased epididymis weight 0.346728462865227 0.791603483042952 0.985221554246814 0.260869565217391 12.5 12 5 abnormal B cell morphology 0.346728462865227 0.791603483042952 0.985221554246814 0.260869565217391 12.5 12 5 abnormal lens development 0.346728462865227 0.791603483042952 0.985221554246814 0.260869565217391 12.5 12 5 abnormal palatal shelf fusion at midline 0.346728462865227 0.791603483042952 0.985221554246814 0.260869565217391 12.5 12 5 abnormal basicranium morphology 0.346728462865227 0.791603483042952 0.985221554246814 0.260869565217391 12.5 12 5 abnormal epidermal layer morphology 0.181227611946484 0.606945107519923 0.985221554246813 0.260869565217391 12.5 12 5 short stride length 0.23460620068785 0.645199473975706 0.981937482399324 0.26 12.5 12 5 abnormal osteoblast physiology 0.226718149462193 0.631889520209755 0.979139939714426 0.259259259259259 12.5 12 5 abnormal heart valve morphology 0.330361592311607 0.791603483042952 0.979139939714426 0.259259259259259 12.5 12 5 cryptorchism 0.330361592311607 0.791603483042952 0.979139939714426 0.259259259259259 12.5 12 5 decreased susceptibility to pharmacologically induced seizures 0.330361592311607 0.791603483042952 0.979139939714426 0.259259259259259 12.5 12 5 decreased bone ossification 0.330361592311607 0.791603483042952 0.979139939714426 0.259259259259259 12.5 12 5 cochlear ganglion degeneration 0.219233565216527 0.624668028176135 0.976728264986065 0.258620689655172 12.5 12 5 abnormal enzyme/coenzyme level 0.219233565216527 0.624668028176135 0.976728264986065 0.258620689655172 12.5 12 5 abnormal retinal photoreceptor layer morphology 0.315695080066726 0.785291511665982 0.974627774093622 0.258064516129032 12.5 12 5 decreased neuronal precursor cell number 0.315695080066726 0.785291511665982 0.974627774093622 0.258064516129032 12.5 12 5 abnormal podocyte morphology 0.315695080066726 0.785291511665982 0.974627774093622 0.258064516129032 12.5 12 5 abnormal tail morphology 0.205338440602365 0.606945107519923 0.972781888157839 0.257575757575758 12.5 12 5 impaired fertilization 0.198870864911653 0.606945107519923 0.971146960614716 0.257142857142857 12.5 12 5 thick epidermis 0.198870864911653 0.606945107519923 0.971146960614716 0.257142857142857 12.5 12 5 impaired adaptive thermogenesis 0.302376235667475 0.758991812535666 0.971146960614716 0.257142857142857 12.5 12 5 increased circulating alanine transaminase level 0.186778632121595 0.606945107519923 0.968380160157124 0.256410256410256 12.5 12 5 increased vascular permeability 0.290159904075826 0.731650036886586 0.968380160157124 0.256410256410256 12.5 12 5 kidney failure 0.278867665966509 0.723839309383726 0.966128113273038 0.255813953488372 12.5 12 5 decreased oxygen consumption 0.278867665966509 0.723839309383726 0.966128113273038 0.255813953488372 12.5 12 5 cleft secondary palate 0.165462311017843 0.606945107519923 0.964259393518158 0.25531914893617 12.5 12 5 improved glucose tolerance 0.0704113708939657 0.355479416422189 0.963439445054282 0.255102040816327 12.5 12 5 distended abdomen 0.258547091930214 0.704034910975814 0.962683806273847 0.254901960784314 12.5 12 5 abnormal limb morphology 0.21027774346466 0.609278843178034 0.956759598235239 0.253333333333333 12.5 12 5 abnormal locomotor activation 0.185254880833543 0.606945107519923 0.954546157869166 0.252747252747253 12.5 12 5 abnormal tooth morphology 0.253544784673676 0.69268825027542 0.944170656153197 0.25 12.5 12 5 abnormal vertebral body morphology 0.350262077179934 0.791603483042952 0.944170656153197 0.25 12.5 12 5 abnormal heart atrium morphology 0.350262077179934 0.791603483042952 0.944170656153197 0.25 12.5 12 5 decreased kidney weight 0.283302361336078 0.723839309383726 0.944170656153196 0.25 12.5 12 5 hyperglycemia 0.207164042253344 0.606945107519923 0.944170656153196 0.25 12.5 12 5 abnormal urine homeostasis 0.194465842744852 0.606945107519923 0.944170656153196 0.25 12.5 12 5 abnormal eye physiology 0.262851838267338 0.715365369463898 0.944170656153196 0.25 12.5 12 5 abnormal cardiovascular system morphology 0.294612638079967 0.740251451741331 0.944170656153196 0.25 12.5 12 5 hypertension 0.306791903514239 0.764674208408487 0.944170656153196 0.25 12.5 12 5 abnormal gametogenesis 0.306791903514239 0.764674208408487 0.944170656153196 0.25 12.5 12 5 renal interstitial fibrosis 0.306791903514239 0.764674208408487 0.944170656153196 0.25 12.5 12 5 decreased sensitivity to induced morbidity/mortality 0.306791903514239 0.764674208408487 0.944170656153196 0.25 12.5 12 5 abnormal jaw morphology 0.367966334782544 0.791603483042952 0.944170656153196 0.25 12.5 12 5 reddish skin 0.367966334782544 0.791603483042952 0.944170656153196 0.25 12.5 12 5 abnormal body weight 0.388039537891273 0.813868760965043 0.944170656153196 0.25 12.5 12 5 abnormal impulse conducting system conduction 0.388039537891273 0.813868760965043 0.944170656153196 0.25 12.5 12 5 abnormal uterus morphology 0.334390478410608 0.791603483042952 0.944170656153196 0.25 12.5 12 5 abnormal limb bone morphology 0.334390478410608 0.791603483042952 0.944170656153196 0.25 12.5 12 5 abnormal basioccipital bone morphology 0.411321686499366 0.856006138210112 0.944170656153196 0.25 12.5 12 5 abnormal pericardium morphology 0.411321686499366 0.856006138210112 0.944170656153196 0.25 12.5 12 5 abnormal optic stalk morphology 0.411321686499366 0.856006138210112 0.944170656153196 0.25 12.5 12 5 abnormal induced retinal neovascularization 0.411321686499366 0.856006138210112 0.944170656153196 0.25 12.5 12 5 enhanced behavioral response to xenobiotic 0.411321686499366 0.856006138210112 0.944170656153196 0.25 12.5 12 5 abnormal heart electrocardiography waveform feature 0.411321686499366 0.856006138210112 0.944170656153196 0.25 12.5 12 5 decreased muscle cell glucose uptake 0.411321686499366 0.856006138210112 0.944170656153196 0.25 12.5 12 5 abnormal eye electrophysiology 0.174538225682845 0.606945107519923 0.936367592879203 0.247933884297521 12.5 12 5 increased circulating HDL cholesterol level 0.197086444678162 0.606945107519923 0.935178554666023 0.247619047619048 12.5 12 5 obese 0.24753532782675 0.680004558773099 0.931908699579778 0.246753246753247 12.5 12 5 decreased susceptibility to induced arthritis 0.296858175346428 0.745517123850823 0.927606258676824 0.245614035087719 12.5 12 5 organ of Corti degeneration 0.321537096309474 0.791603483042952 0.924901867252111 0.244897959183673 12.5 12 5 absent kidney 0.321537096309474 0.791603483042952 0.924901867252111 0.244897959183673 12.5 12 5 abnormal epidermis stratum corneum morphology 0.321537096309474 0.791603483042952 0.924901867252111 0.244897959183673 12.5 12 5 increased fluid intake 0.321537096309474 0.791603483042952 0.924901867252111 0.244897959183673 12.5 12 5 increased anxiety-related response 0.178073691166189 0.606945107519923 0.923792872207444 0.244604316546763 12.5 12 5 altered response to myocardial infarction 0.335365715571769 0.791603483042952 0.923189086016459 0.244444444444444 12.5 12 5 decreased osteoclast cell number 0.335365715571769 0.791603483042952 0.923189086016459 0.244444444444444 12.5 12 5 abnormal metabolism 0.335365715571769 0.791603483042952 0.923189086016459 0.244444444444444 12.5 12 5 abnormal response/metabolism to endogenous compounds 0.257987473180471 0.702895771671874 0.921142103564094 0.24390243902439 12.5 12 5 absent gastric milk in neonates 0.267101043392818 0.723839309383726 0.919961152149268 0.243589743589744 12.5 12 5 abnormal intestine morphology 0.276726557005305 0.723839309383726 0.918652530311218 0.243243243243243 12.5 12 5 increased brown adipose tissue amount 0.366936321476506 0.791603483042952 0.918652530311218 0.243243243243243 12.5 12 5 abnormal breathing pattern 0.366936321476506 0.791603483042952 0.918652530311218 0.243243243243243 12.5 12 5 decreased circulating chloride level 0.366936321476506 0.791603483042952 0.918652530311218 0.243243243243243 12.5 12 5 abnormal action potential 0.286916807659238 0.723839309383726 0.917194351691676 0.242857142857143 12.5 12 5 deafness 0.242323994909187 0.666056284349837 0.915559424148554 0.242424242424242 12.5 12 5 absent vibrissae 0.385246668749002 0.812119566536562 0.915559424148554 0.242424242424242 12.5 12 5 single kidney 0.385246668749002 0.812119566536562 0.915559424148554 0.242424242424242 12.5 12 5 diarrhea 0.385246668749002 0.812119566536562 0.915559424148554 0.242424242424242 12.5 12 5 short limbs 0.267872316955516 0.723839309383726 0.911613047320327 0.241379310344828 12.5 12 5 increased susceptibility to induced arthritis 0.405808895560673 0.84934760429716 0.911613047320327 0.241379310344828 12.5 12 5 increased body weight 0.138719395457428 0.557454759612845 0.910450275576296 0.241071428571429 12.5 12 5 abnormal chondrocyte morphology 0.334758702159068 0.791603483042952 0.909201372591967 0.240740740740741 12.5 12 5 abnormal maxilla morphology 0.334758702159068 0.791603483042952 0.909201372591967 0.240740740740741 12.5 12 5 polyphagia 0.334758702159068 0.791603483042952 0.909201372591967 0.240740740740741 12.5 12 5 abnormal hindlimb morphology 0.348988958084724 0.791603483042952 0.906403829907068 0.24 12.5 12 5 kidney inflammation 0.348988958084724 0.791603483042952 0.906403829907068 0.24 12.5 12 5 decreased respiratory quotient 0.348988958084724 0.791603483042952 0.906403829907068 0.24 12.5 12 5 abnormal keratinocyte physiology 0.429299046228418 0.885841043129979 0.906403829907068 0.24 12.5 12 5 increased liver glycogen level 0.429299046228418 0.885841043129979 0.906403829907068 0.24 12.5 12 5 abnormal inner ear morphology 0.364414125233777 0.791603483042952 0.903119758059579 0.239130434782609 12.5 12 5 increased bone mineral density 0.251094359602525 0.687125654027812 0.90239319349155 0.238938053097345 12.5 12 5 short femur 0.286900283653211 0.723839309383726 0.901253808146233 0.238636363636364 12.5 12 5 abnormal muscle morphology 0.381247471734236 0.804711994856948 0.89921014871733 0.238095238095238 12.5 12 5 abnormal scapula morphology 0.456772477315685 0.91079882751324 0.89921014871733 0.238095238095238 12.5 12 5 abnormal associative learning 0.456772477315685 0.91079882751324 0.89921014871733 0.238095238095238 12.5 12 5 increased vasoconstriction 0.456772477315685 0.91079882751324 0.89921014871733 0.238095238095238 12.5 12 5 left pulmonary isomerism 0.456772477315685 0.91079882751324 0.89921014871733 0.238095238095238 12.5 12 5 abnormal bile salt homeostasis 0.456772477315685 0.91079882751324 0.89921014871733 0.238095238095238 12.5 12 5 complete atrioventricular septal defect 0.456772477315685 0.91079882751324 0.89921014871733 0.238095238095238 12.5 12 5 abnormal social investigation 0.3078098002831 0.766827118882536 0.896962123345536 0.2375 12.5 12 5 increased grooming behavior 0.399768801032785 0.837410435847622 0.894477463724081 0.236842105263158 12.5 12 5 abnormal digit morphology 0.331205896525044 0.791603483042952 0.891716730811352 0.236111111111111 12.5 12 5 circling 0.317294133345071 0.788874719336195 0.888631205791244 0.235294117647059 12.5 12 5 decreased susceptibility to injury 0.344005129642115 0.791603483042952 0.888631205791244 0.235294117647059 12.5 12 5 thin skin 0.420355728005849 0.868828311935645 0.888631205791244 0.235294117647059 12.5 12 5 abnormal vision 0.420355728005849 0.868828311935645 0.888631205791244 0.235294117647059 12.5 12 5 decreased pancreatic beta cell number 0.420355728005849 0.868828311935645 0.888631205791244 0.235294117647059 12.5 12 5 cardiac hypertrophy 0.30464472864545 0.763830664782175 0.886364289449939 0.23469387755102 12.5 12 5 increased systemic arterial blood pressure 0.393762496581246 0.825176251260193 0.883904444058311 0.234042553191489 12.5 12 5 abnormal response to new environment 0.443535683834899 0.897917452800588 0.881225945742983 0.233333333333333 12.5 12 5 abnormal spatial learning 0.253971282304001 0.693472628684086 0.880453618007888 0.233128834355828 12.5 12 5 abnormal CNS synaptic transmission 0.323504950697213 0.791603483042952 0.877411114809031 0.232323232323232 12.5 12 5 short mandible 0.387942651165825 0.813868760965043 0.876729894999397 0.232142857142857 12.5 12 5 abnormal excitatory postsynaptic potential 0.35018701468903 0.791603483042952 0.875084998385889 0.231707317073171 12.5 12 5 abnormal female meiosis 0.404871683571122 0.847742687612093 0.871542144141412 0.230769230769231 12.5 12 5 abnormal iris morphology 0.432651470119873 0.891639370447934 0.871542144141412 0.230769230769231 12.5 12 5 abnormal response to injury 0.432651470119873 0.891639370447934 0.871542144141412 0.230769230769231 12.5 12 5 decreased trabecular bone volume 0.432651470119873 0.891639370447934 0.871542144141412 0.230769230769231 12.5 12 5 abnormal nasal bone morphology 0.470077483717743 0.923351169447441 0.871542144141412 0.230769230769231 12.5 12 5 abnormal Schwann cell morphology 0.470077483717743 0.923351169447441 0.871542144141412 0.230769230769231 12.5 12 5 increased susceptibility to otitis media 0.470077483717743 0.923351169447441 0.871542144141412 0.230769230769231 12.5 12 5 abnormal ocular fundus morphology 0.470077483717743 0.923351169447441 0.871542144141412 0.230769230769231 12.5 12 5 increased susceptibility to pharmacologically induced seizures 0.354480229434937 0.791603483042952 0.86548976814043 0.229166666666667 12.5 12 5 abnormal intestinal goblet cell morphology 0.455312614624626 0.910076439436527 0.863241742768637 0.228571428571429 12.5 12 5 decreased bone mineralization 0.455312614624626 0.910076439436527 0.863241742768637 0.228571428571429 12.5 12 5 abnormal photoreceptor outer segment morphology 0.443295111707855 0.897917452800588 0.858336960139269 0.227272727272727 12.5 12 5 cochlear hair cell degeneration 0.443295111707855 0.897917452800588 0.858336960139269 0.227272727272727 12.5 12 5 abnormal facial nerve morphology 0.501164578433003 0.923351169447441 0.858336960139269 0.227272727272727 12.5 12 5 decreased airway responsiveness 0.501164578433003 0.923351169447441 0.858336960139269 0.227272727272727 12.5 12 5 abnormal cochlear sensory epithelium morphology 0.501164578433003 0.923351169447441 0.858336960139269 0.227272727272727 12.5 12 5 abnormal retinal outer plexiform layer morphology 0.501164578433003 0.923351169447441 0.858336960139269 0.227272727272727 12.5 12 5 abnormal circulating lipid level 0.501164578433003 0.923351169447441 0.858336960139269 0.227272727272727 12.5 12 5 abnormal limb posture 0.501164578433003 0.923351169447441 0.858336960139269 0.227272727272727 12.5 12 5 impaired swimming 0.407234848971012 0.851973664268623 0.858336960139269 0.227272727272727 12.5 12 5 enlarged kidney 0.433005169648685 0.891639370447934 0.855097952742517 0.226415094339623 12.5 12 5 abnormal pancreatic islet morphology 0.433005169648685 0.891639370447934 0.855097952742517 0.226415094339623 12.5 12 5 hydronephrosis 0.393681966942683 0.825176251260193 0.854249641281463 0.226190476190476 12.5 12 5 impaired ovarian folliculogenesis 0.465360496701308 0.923351169447441 0.849753590537877 0.225 12.5 12 5 abnormal autopod morphology 0.474132082032451 0.923351169447441 0.839262805469508 0.222222222222222 12.5 12 5 abnormal ovarian follicle morphology 0.474132082032451 0.923351169447441 0.839262805469508 0.222222222222222 12.5 12 5 abnormal cell migration 0.474132082032451 0.923351169447441 0.839262805469508 0.222222222222222 12.5 12 5 abnormal mandible morphology 0.461075588931433 0.918642793325543 0.839262805469508 0.222222222222222 12.5 12 5 abnormal long bone epiphyseal plate proliferative zone 0.461075588931433 0.918642793325543 0.839262805469508 0.222222222222222 12.5 12 5 abnormal epidermis stratum granulosum morphology 0.48986179640006 0.923351169447441 0.839262805469508 0.222222222222222 12.5 12 5 reduced long term depression 0.48986179640006 0.923351169447441 0.839262805469508 0.222222222222222 12.5 12 5 abnormal atrioventricular cushion morphology 0.509996309833781 0.929729439876534 0.839262805469508 0.222222222222222 12.5 12 5 abnormal trigeminal nerve morphology 0.509996309833781 0.929729439876534 0.839262805469508 0.222222222222222 12.5 12 5 abnormal palate morphology 0.509996309833781 0.929729439876534 0.839262805469508 0.222222222222222 12.5 12 5 abnormal bone trabecula morphology 0.509996309833781 0.929729439876534 0.839262805469508 0.222222222222222 12.5 12 5 decreased cardiac muscle contractility 0.421491493926384 0.870814029187607 0.83522788813552 0.221153846153846 12.5 12 5 impaired righting response 0.429290773846393 0.885841043129979 0.834845632809142 0.221052631578947 12.5 12 5 polyuria 0.446957781036003 0.897917452800588 0.833813046992433 0.220779220779221 12.5 12 5 abnormal colon morphology 0.468676413896259 0.923351169447441 0.832150408812987 0.220338983050847 12.5 12 5 abnormal axon extension 0.481925737062102 0.923351169447441 0.830870177414813 0.22 12.5 12 5 short humerus 0.497687979109789 0.923351169447441 0.829027893207684 0.219512195121951 12.5 12 5 abnormal cholesterol homeostasis 0.497687979109789 0.923351169447441 0.829027893207684 0.219512195121951 12.5 12 5 palatal shelves fail to meet at midline 0.497687979109789 0.923351169447441 0.829027893207684 0.219512195121951 12.5 12 5 increased dopamine level 0.517379452438406 0.937419071725902 0.826149324134047 0.21875 12.5 12 5 pancreatic islet hyperplasia 0.517379452438406 0.937419071725902 0.826149324134047 0.21875 12.5 12 5 abnormal auditory brainstem response waveform shape 0.517379452438406 0.937419071725902 0.826149324134047 0.21875 12.5 12 5 abnormal food intake 0.482029102652568 0.923351169447441 0.821017961872345 0.217391304347826 12.5 12 5 fragile skeleton 0.544063499424051 0.963587009481899 0.821017961872345 0.217391304347826 12.5 12 5 bidirectional circling 0.544063499424051 0.963587009481899 0.821017961872345 0.217391304347826 12.5 12 5 hypotension 0.544063499424051 0.963587009481899 0.821017961872345 0.217391304347826 12.5 12 5 malocclusion 0.52377227224104 0.937419071725902 0.816580026943305 0.216216216216216 12.5 12 5 abnormal vocalization 0.52377227224104 0.937419071725902 0.816580026943305 0.216216216216216 12.5 12 5 increased insulin secretion 0.52377227224104 0.937419071725902 0.816580026943305 0.216216216216216 12.5 12 5 abnormal pancreatic beta cell physiology 0.52377227224104 0.937419071725902 0.816580026943305 0.216216216216216 12.5 12 5 abnormal hair follicle development 0.52377227224104 0.937419071725902 0.816580026943305 0.216216216216216 12.5 12 5 abnormal calcium ion homeostasis 0.52377227224104 0.937419071725902 0.816580026943305 0.216216216216216 12.5 12 5 abnormal humerus morphology 0.52377227224104 0.937419071725902 0.816580026943305 0.216216216216216 12.5 12 5 enhanced long term potentiation 0.51649450830029 0.937419071725902 0.809289133845597 0.214285714285714 12.5 12 5 myoclonus 0.548731757575027 0.970128107297712 0.809289133845597 0.214285714285714 12.5 12 5 absent corpus callosum 0.548731757575027 0.970128107297712 0.809289133845597 0.214285714285714 12.5 12 5 enhanced coordination 0.548731757575027 0.970128107297712 0.809289133845597 0.214285714285714 12.5 12 5 abnormal hormone level 0.548731757575027 0.970128107297712 0.809289133845597 0.214285714285714 12.5 12 5 corneal vascularization 0.548731757575027 0.970128107297712 0.809289133845597 0.214285714285714 12.5 12 5 decreased circulating cholesterol level 0.4793068703962 0.923351169447441 0.804866788851905 0.213114754098361 12.5 12 5 abnormal male meiosis 0.521704241643876 0.937419071725902 0.804866788851905 0.213114754098361 12.5 12 5 abnormal tibia morphology 0.534567885679455 0.952875396365205 0.803549494598465 0.212765957446809 12.5 12 5 dextrocardia 0.552953663431707 0.976897896155093 0.801114496129985 0.212121212121212 12.5 12 5 abnormal QRS complex 0.552953663431707 0.976897896155093 0.801114496129985 0.212121212121212 12.5 12 5 abnormal hair growth 0.539258574054722 0.956098148938789 0.798913632129628 0.211538461538462 12.5 12 5 increased susceptibility to injury 0.539258574054722 0.956098148938789 0.798913632129628 0.211538461538462 12.5 12 5 abnormal reproductive system physiology 0.556839864563241 0.982368200780896 0.79509107886585 0.210526315789474 12.5 12 5 impaired branching involved in ureteric bud morphogenesis 0.556839864563241 0.982368200780896 0.79509107886585 0.210526315789474 12.5 12 5 hyporesponsive to tactile stimuli 0.556839864563241 0.982368200780896 0.79509107886585 0.210526315789474 12.5 12 5 decreased threshold for auditory brainstem response 0.556839864563241 0.982368200780896 0.79509107886585 0.210526315789474 12.5 12 5 abnormal organ of Corti morphology 0.560460817368062 0.988405730735948 0.790468456314304 0.209302325581395 12.5 12 5 abnormal hair shaft morphology 0.56386483413692 0.993704410142111 0.786808880127664 0.208333333333333 12.5 12 5 abnormal phalanx morphology 0.56386483413692 0.993704410142111 0.786808880127664 0.208333333333333 12.5 12 5 abnormal primitive streak formation 0.585122436669519 1 0.786808880127664 0.208333333333333 12.5 12 5 abnormal middle ear morphology 0.586015982448337 1 0.781382611988852 0.206896551724138 12.5 12 5 focal hair loss 0.586015982448337 1 0.781382611988852 0.206896551724138 12.5 12 5 abnormal skin physiology 0.587330905949522 1 0.777552305067338 0.205882352941176 12.5 12 5 small lens 0.58888848248411 1 0.7747041281257 0.205128205128205 12.5 12 5 abnormal lens fiber morphology 0.58888848248411 1 0.7747041281257 0.205128205128205 12.5 12 5 abnormal excitatory postsynaptic currents 0.581212683751576 1 0.7747041281257 0.205128205128205 12.5 12 5 abnormal nervous system electrophysiology 0.605306747868364 1 0.76432862640973 0.202380952380952 12.5 12 5 abnormal trabecular bone morphology 0.617492680017402 1 0.761683890678209 0.201680672268908 12.5 12 5 abnormal digestive system physiology 0.619985886754933 1 0.755336524922557 0.2 12.5 12 5 abnormal lactation 0.621636057101697 1 0.755336524922557 0.2 12.5 12 5 abnormal pain threshold 0.621636057101697 1 0.755336524922557 0.2 12.5 12 5 abnormal skin pigmentation 0.619770478929811 1 0.755336524922557 0.2 12.5 12 5 abnormal long bone epiphyseal plate morphology 0.621241116466465 1 0.755336524922557 0.2 12.5 12 5 abnormal incisor morphology 0.621241116466465 1 0.755336524922557 0.2 12.5 12 5 abnormal energy expenditure 0.624078284279795 1 0.755336524922557 0.2 12.5 12 5 abnormal stomach mucosa morphology 0.624078284279795 1 0.755336524922557 0.2 12.5 12 5 decreased bone volume 0.620335478780746 1 0.755336524922557 0.2 12.5 12 5 abnormal response to novel object 0.646609132794944 1 0.740526004826036 0.196078431372549 12.5 12 5 increased kidney weight 0.646609132794944 1 0.740526004826036 0.196078431372549 12.5 12 5 abnormal dendritic spine morphology 0.646609132794944 1 0.740526004826036 0.196078431372549 12.5 12 5 renal hypoplasia 0.651829126251946 1 0.734354954785819 0.194444444444444 12.5 12 5 abnormal retinal blood vessel morphology 0.651829126251946 1 0.734354954785819 0.194444444444444 12.5 12 5 abnormal femur morphology 0.668191763364343 1 0.732789165969645 0.194029850746269 12.5 12 5 abnormal object recognition memory 0.655431304421956 1 0.730970830570217 0.193548387096774 12.5 12 5 abnormal intestine physiology 0.655431304421956 1 0.730970830570217 0.193548387096774 12.5 12 5 small kidney 0.686126018196239 1 0.729586416118379 0.193181818181818 12.5 12 5 abnormal xiphoid process morphology 0.660745141556474 1 0.726285120117843 0.192307692307692 12.5 12 5 abnormal brain wave pattern 0.672168789637854 1 0.726285120117843 0.192307692307692 12.5 12 5 decreased body temperature 0.672168789637854 1 0.726285120117843 0.192307692307692 12.5 12 5 decreased inflammatory response 0.705909187296792 1 0.719368118973864 0.19047619047619 12.5 12 5 decreased food intake 0.707281094042629 1 0.717091637584706 0.189873417721519 12.5 12 5 abnormal coat appearance 0.710950558602782 1 0.711548900289365 0.188405797101449 12.5 12 5 kidney cortex cysts 0.687289424110468 1 0.708127992114897 0.1875 12.5 12 5 abnormal lymphatic vessel morphology 0.687289424110468 1 0.708127992114897 0.1875 12.5 12 5 abnormal long term potentiation 0.687289424110468 1 0.708127992114897 0.1875 12.5 12 5 decreased susceptibility to parasitic infection 0.687289424110468 1 0.708127992114897 0.1875 12.5 12 5 abnormal intestinal mucosa morphology 0.704353932117998 1 0.702638627834937 0.186046511627907 12.5 12 5 dehydration 0.730994471414525 1 0.701383915999517 0.185714285714286 12.5 12 5 abnormal compact bone morphology 0.70990532853316 1 0.695704694007618 0.184210526315789 12.5 12 5 decreased urine osmolality 0.724244364946765 1 0.693676400439083 0.183673469387755 12.5 12 5 abnormal tooth development 0.717141815372415 1 0.686669568111415 0.181818181818182 12.5 12 5 abnormal middle ear ossicle morphology 0.717141815372415 1 0.686669568111415 0.181818181818182 12.5 12 5 head tossing 0.717141815372415 1 0.686669568111415 0.181818181818182 12.5 12 5 increased circulating chloride level 0.747130372354729 1 0.679802872430301 0.18 12.5 12 5 increased bone resorption 0.726805040131841 1 0.674407611537997 0.178571428571429 12.5 12 5 abnormal cartilage development 0.753403989106514 1 0.671410244375606 0.177777777777778 12.5 12 5 increased width of hypertrophic chondrocyte zone 0.744958438820178 1 0.666473404343433 0.176470588235294 12.5 12 5 head bobbing 0.761112642174148 1 0.660919459307237 0.175 12.5 12 5 abnormal forelimb morphology 0.775657613709436 1 0.656814369497876 0.173913043478261 12.5 12 5 delayed wound healing 0.775657613709436 1 0.656814369497876 0.173913043478261 12.5 12 5 abnormal spinal nerve morphology 0.756136093815905 1 0.651152176657377 0.172413793103448 12.5 12 5 decreased bone strength 0.756136093815905 1 0.651152176657377 0.172413793103448 12.5 12 5 increased retinal apoptosis 0.756136093815905 1 0.651152176657377 0.172413793103448 12.5 12 5 abnormal artery morphology 0.770742499517991 1 0.647431307076477 0.171428571428571 12.5 12 5 impaired behavioral response to xenobiotic 0.770742499517991 1 0.647431307076477 0.171428571428571 12.5 12 5 increased bone trabecula number 0.784119255114897 1 0.644799472494866 0.170731707317073 12.5 12 5 syndactyly 0.818223019712922 1 0.640115699086913 0.169491525423729 12.5 12 5 abnormal systemic arterial blood pressure 0.7945251741712 1 0.629447104102131 0.166666666666667 12.5 12 5 short radius 0.7945251741712 1 0.629447104102131 0.166666666666667 12.5 12 5 head tilt 0.7945251741712 1 0.629447104102131 0.166666666666667 12.5 12 5 decreased compact bone thickness 0.856632706064692 1 0.620052371205084 0.164179104477612 12.5 12 5 impaired skeletal muscle contractility 0.816360551329274 1 0.612435020207479 0.162162162162162 12.5 12 5 abnormal nose morphology 0.80757548514659 1 0.609142358808514 0.161290322580645 12.5 12 5 decreased susceptibility to bacterial infection induced morbidity/mortality 0.80757548514659 1 0.609142358808514 0.161290322580645 12.5 12 5 abnormal diaphragm morphology 0.829850681634761 1 0.590106660095748 0.15625 12.5 12 5 abnormal serotonin level 0.829850681634761 1 0.590106660095748 0.15625 12.5 12 5 increased percent body fat/body weight 0.87897673522795 1 0.581028096094275 0.153846153846154 12.5 12 5 abnormal innervation 0.888453399051742 1 0.562484646218925 0.148936170212766 12.5 12 5 impaired synaptic plasticity 0.86808395904688 1 0.555394503619527 0.147058823529412 12.5 12 5 abnormal axon guidance 0.911295851461496 1 0.526978970876203 0.13953488372093 12.5 12 5 abnormal reflex 0.89878856167758 1 0.524539253418442 0.138888888888889 12.5 12 5 abnormal inhibitory postsynaptic currents 0.962750718814207 1 0.499855053257574 0.132352941176471 12.5 12 5 abnormal cochlea morphology 0.953193492821437 1 0.489569969857213 0.12962962962963 12.5 12 5 short ulna 0.949862012665264 1 0.460571051782047 0.121951219512195 12.5 12 5 decreased B-1 B cell number 2.03788782391316e-11 7.85929606509146e-10 0.878925505400166 1 12.4 12 4 spleen atrophy 3.30879382390751e-06 4.57256924276107e-05 0.878925505400166 1 12.4 12 4 abnormal thymocyte activation 3.30879382390751e-06 4.57256924276107e-05 0.878925505400166 1 12.4 12 4 increased skin tumor incidence 3.30879382390751e-06 4.57256924276107e-05 0.878925505400166 1 12.4 12 4 kidney hemorrhage 0.00182136885770022 0.011131830549212 0.878925505400166 1 12.4 12 4 enlarged testis 0.00182136885770022 0.011131830549212 0.878925505400166 1 12.4 12 4 abnormal immune cell physiology 0.00182136885770022 0.011131830549212 0.878925505400166 1 12.4 12 4 aneurysm 0.00182136885770022 0.011131830549212 0.878925505400166 1 12.4 12 4 absent CD4-positive, alpha beta T cells 0.00182136885770022 0.011131830549212 0.878925505400166 1 12.4 12 4 abnormal corneal endothelium morphology 0.00182136885770022 0.011131830549212 0.878925505400166 1 12.4 12 4 osteosclerosis 0.00182136885770022 0.011131830549212 0.878925505400166 1 12.4 12 4 increased platelet aggregation 0.00182136885770022 0.011131830549212 0.878925505400166 1 12.4 12 4 decreased transitional stage T2 B cell number 0.00182136885770022 0.011131830549212 0.878925505400166 1 12.4 12 4 acanthocytosis 0.00182136885770022 0.011131830549212 0.878925505400166 1 12.4 12 4 abnormal inferior vena cava valve morphology 0.00182136885770022 0.011131830549212 0.878925505400166 1 12.4 12 4 thin ventricle myocardium compact layer 0.00182136885770022 0.011131830549212 0.878925505400166 1 12.4 12 4 thick aortic valve cusps 0.00182136885770022 0.011131830549212 0.878925505400166 1 12.4 12 4 decreased macrophage cytokine production 0.00182136885770022 0.011131830549212 0.878925505400166 1 12.4 12 4 lethality during fetal growth through weaning, complete penetrance 0.00182136885770022 0.011131830549212 0.878925505400166 1 12.4 12 4 increased fatty acid oxidation 0.00182136885770022 0.011131830549212 0.878925505400166 1 12.4 12 4 small hair follicles 0.0426913272416403 0.135538834095189 0.878925505400166 1 12.4 12 4 abnormal pineal gland morphology 0.0426913272416403 0.135538834095189 0.878925505400166 1 12.4 12 4 optic nerve atrophy 0.0426913272416403 0.135538834095189 0.878925505400166 1 12.4 12 4 ovary hyperplasia 0.0426913272416403 0.135538834095189 0.878925505400166 1 12.4 12 4 absent lungs 0.0426913272416403 0.135538834095189 0.878925505400166 1 12.4 12 4 kinked vibrissae 0.0426913272416403 0.135538834095189 0.878925505400166 1 12.4 12 4 corneal scarring 0.0426913272416403 0.135538834095189 0.878925505400166 1 12.4 12 4 abnormal penile erection 0.0426913272416403 0.135538834095189 0.878925505400166 1 12.4 12 4 sinus inflammation 0.0426913272416403 0.135538834095189 0.878925505400166 1 12.4 12 4 abnormal respiratory sounds 0.0426913272416403 0.135538834095189 0.878925505400166 1 12.4 12 4 increased hepatic hemangioma incidence 0.0426913272416403 0.135538834095189 0.878925505400166 1 12.4 12 4 abnormal oropharynx morphology 0.0426913272416403 0.135538834095189 0.878925505400166 1 12.4 12 4 improved righting response 0.0426913272416403 0.135538834095189 0.878925505400166 1 12.4 12 4 decreased superior colliculus size 0.0426913272416403 0.135538834095189 0.878925505400166 1 12.4 12 4 decreased lysosomal enzyme secretion 0.0426913272416403 0.135538834095189 0.878925505400166 1 12.4 12 4 enhanced NMDA-mediated synaptic currents 0.0426913272416403 0.135538834095189 0.878925505400166 1 12.4 12 4 gastric polyps 0.0426913272416403 0.135538834095189 0.878925505400166 1 12.4 12 4 epidermal cyst 0.0426913272416403 0.135538834095189 0.878925505400166 1 12.4 12 4 sirenomelia 0.0426913272416403 0.135538834095189 0.878925505400166 1 12.4 12 4 abnormal response to vitamins 0.0426913272416403 0.135538834095189 0.878925505400166 1 12.4 12 4 decreased autoantibody level 0.0426913272416403 0.135538834095189 0.878925505400166 1 12.4 12 4 ectopic cartilage 0.0426913272416403 0.135538834095189 0.878925505400166 1 12.4 12 4 increased heart right ventricle weight 0.0426913272416403 0.135538834095189 0.878925505400166 1 12.4 12 4 abnormal urinary system development 0.0426913272416403 0.135538834095189 0.878925505400166 1 12.4 12 4 absent frontal bone 0.0426913272416403 0.135538834095189 0.878925505400166 1 12.4 12 4 abnormal T cell selection 0.0426913272416403 0.135538834095189 0.878925505400166 1 12.4 12 4 abnormal inner cell mass proliferation 0.0426913272416403 0.135538834095189 0.878925505400166 1 12.4 12 4 abnormal immune tolerance 0.0426913272416403 0.135538834095189 0.878925505400166 1 12.4 12 4 erythroblastosis 0.0426913272416403 0.135538834095189 0.878925505400166 1 12.4 12 4 abnormal tail pigmentation 0.0426913272416403 0.135538834095189 0.878925505400166 1 12.4 12 4 decreased unsaturated fatty acid level 0.0426913272416403 0.135538834095189 0.878925505400166 1 12.4 12 4 intrahepatic cholestasis 0.0426913272416403 0.135538834095189 0.878925505400166 1 12.4 12 4 corneal deposits 0.0426913272416403 0.135538834095189 0.878925505400166 1 12.4 12 4 abnormal hemoglobin content 0.0426913272416403 0.135538834095189 0.878925505400166 1 12.4 12 4 enlarged axillary lymph nodes 0.0426913272416403 0.135538834095189 0.878925505400166 1 12.4 12 4 increased placenta apoptosis 0.0426913272416403 0.135538834095189 0.878925505400166 1 12.4 12 4 absent optic chiasm 0.0426913272416403 0.135538834095189 0.878925505400166 1 12.4 12 4 abnormal mismatch repair 0.0426913272416403 0.135538834095189 0.878925505400166 1 12.4 12 4 impaired gastric peristalsis 0.0426913272416403 0.135538834095189 0.878925505400166 1 12.4 12 4 abnormal ascending aorta morphology 0.0426913272416403 0.135538834095189 0.878925505400166 1 12.4 12 4 abnormal arcus anterior morphology 0.0426913272416403 0.135538834095189 0.878925505400166 1 12.4 12 4 palatal shelf fusion with tongue or mandible 0.0426913272416403 0.135538834095189 0.878925505400166 1 12.4 12 4 abnormal hyoid bone greater horn morphology 0.0426913272416403 0.135538834095189 0.878925505400166 1 12.4 12 4 decreased DN3 thymocyte number 0.0426913272416403 0.135538834095189 0.878925505400166 1 12.4 12 4 hemolysis 0.0426913272416403 0.135538834095189 0.878925505400166 1 12.4 12 4 increased response to stress-induced hyperthermia 0.0426913272416403 0.135538834095189 0.878925505400166 1 12.4 12 4 increased T follicular helper cell number 0.0426913272416403 0.135538834095189 0.878925505400166 1 12.4 12 4 abnormal heart ventricle outflow tract morphology 0.0426913272416403 0.135538834095189 0.878925505400166 1 12.4 12 4 increased thyroid carcinoma incidence 0.0426913272416403 0.135538834095189 0.878925505400166 1 12.4 12 4 increased renal carcinoma incidence 0.0426913272416403 0.135538834095189 0.878925505400166 1 12.4 12 4 calcified aorta 0.0426913272416403 0.135538834095189 0.878925505400166 1 12.4 12 4 aorta hypoplasia 0.0426913272416403 0.135538834095189 0.878925505400166 1 12.4 12 4 prolonged ST segment 0.0426913272416403 0.135538834095189 0.878925505400166 1 12.4 12 4 decreased heart left ventricle size 0.0426913272416403 0.135538834095189 0.878925505400166 1 12.4 12 4 enlarged aortic valve 0.0426913272416403 0.135538834095189 0.878925505400166 1 12.4 12 4 abnormal blood pressure regulation 0.0426913272416403 0.135538834095189 0.878925505400166 1 12.4 12 4 abnormal paranode morphology 0.0426913272416403 0.135538834095189 0.878925505400166 1 12.4 12 4 abnormal alveolar lamellar body morphology 0.0426913272416403 0.135538834095189 0.878925505400166 1 12.4 12 4 increased CD4-positive, alpha-beta memory T cell number 0.0426913272416403 0.135538834095189 0.878925505400166 1 12.4 12 4 decreased CD8-positive, alpha-beta memory T cell number 0.0426913272416403 0.135538834095189 0.878925505400166 1 12.4 12 4 pale lung 0.0426913272416403 0.135538834095189 0.878925505400166 1 12.4 12 4 pulmonary alveolar edema 0.0426913272416403 0.135538834095189 0.878925505400166 1 12.4 12 4 fused right lung lobes 0.0426913272416403 0.135538834095189 0.878925505400166 1 12.4 12 4 blind ureter 0.0426913272416403 0.135538834095189 0.878925505400166 1 12.4 12 4 decreased pre-pro B cell number 0.0426913272416403 0.135538834095189 0.878925505400166 1 12.4 12 4 midface hypoplasia 0.0426913272416403 0.135538834095189 0.878925505400166 1 12.4 12 4 delayed optic fissure closure 0.0426913272416403 0.135538834095189 0.878925505400166 1 12.4 12 4 dilated gastric glands 0.0426913272416403 0.135538834095189 0.878925505400166 1 12.4 12 4 abnormal mammary gland bud morphology 0.0426913272416403 0.135538834095189 0.878925505400166 1 12.4 12 4 abnormal mitophagy 0.0426913272416403 0.135538834095189 0.878925505400166 1 12.4 12 4 decreased small intestinal villus height 0.0426913272416403 0.135538834095189 0.878925505400166 1 12.4 12 4 cystinuria 0.0426913272416403 0.135538834095189 0.878925505400166 1 12.4 12 4 decreased fibroblast chemotaxis 0.0426913272416403 0.135538834095189 0.878925505400166 1 12.4 12 4 abnormal B cell morphology 4.98002488099861e-07 8.3139677124054e-06 0.878925505400166 1 12.4 12 4 decreased tumor incidence 6.22004072962875e-06 8.22997410369762e-05 0.878925505400166 1 12.4 12 4 increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 6.22004072962875e-06 8.22997410369762e-05 0.878925505400166 1 12.4 12 4 abnormal bone marrow cell number 4.13138987203435e-05 0.000435458996045993 0.878925505400166 1 12.4 12 4 large intestinal inflammation 4.13138987203435e-05 0.000435458996045993 0.878925505400166 1 12.4 12 4 abnormal fontanelle morphology 7.76559308042201e-05 0.000747269353483549 0.878925505400166 1 12.4 12 4 immune system phenotype 7.76559308042201e-05 0.000747269353483549 0.878925505400166 1 12.4 12 4 abnormal spleen periarteriolar lymphoid sheath morphology 0.000145962674661665 0.00131313617801408 0.878925505400166 1 12.4 12 4 increased hemangioma incidence 0.000145962674661665 0.00131313617801408 0.878925505400166 1 12.4 12 4 lysosomal protein accumulation 0.000145962674661665 0.00131313617801408 0.878925505400166 1 12.4 12 4 absent common myeloid progenitor cells 0.000274345430686826 0.00223748937322453 0.878925505400166 1 12.4 12 4 increased osteosarcoma incidence 0.000515634996699643 0.00386337968159747 0.878925505400166 1 12.4 12 4 decreased red blood cell distribution width 0.000515634996699643 0.00386337968159747 0.878925505400166 1 12.4 12 4 increased fibrosarcoma incidence 0.000515634996699643 0.00386337968159747 0.878925505400166 1 12.4 12 4 persistent right dorsal aorta 0.000515634996699643 0.00386337968159747 0.878925505400166 1 12.4 12 4 embryonic lethality between implantation and placentation, incomplete penetrance 0.000515634996699643 0.00386337968159747 0.878925505400166 1 12.4 12 4 abnormal sphenoid bone morphology 0.000969116029875582 0.00650654824376656 0.878925505400166 1 12.4 12 4 vasculitis 0.000969116029875582 0.00650654824376656 0.878925505400166 1 12.4 12 4 abnormal radial glial cell morphology 0.000969116029875582 0.00650654824376656 0.878925505400166 1 12.4 12 4 abnormal dorsal-ventral polarity of the somites 0.000969116029875582 0.00650654824376656 0.878925505400166 1 12.4 12 4 aberrant origin of the right subclavian artery 0.000969116029875582 0.00650654824376656 0.878925505400166 1 12.4 12 4 reduced sympathetic cervical ganglion size 0.000969116029875582 0.00650654824376656 0.878925505400166 1 12.4 12 4 abnormal kindling response 0.00342301478493311 0.0183450920777108 0.878925505400166 1 12.4 12 4 increased pheochromocytoma incidence 0.00342301478493311 0.0183450920777108 0.878925505400166 1 12.4 12 4 abnormal gut-associated lymphoid tissue morphology 0.00342301478493311 0.0183450920777108 0.878925505400166 1 12.4 12 4 genetic imprinting 0.00342301478493311 0.0183450920777108 0.878925505400166 1 12.4 12 4 premature bone ossification 0.00342301478493311 0.0183450920777108 0.878925505400166 1 12.4 12 4 liver hyperplasia 0.00342301478493311 0.0183450920777108 0.878925505400166 1 12.4 12 4 abnormal inguinal fat pad morphology 0.00342301478493311 0.0183450920777108 0.878925505400166 1 12.4 12 4 decreased susceptibility to atherosclerosis 0.00342301478493311 0.0183450920777108 0.878925505400166 1 12.4 12 4 abnormal leukopoiesis 0.00342301478493311 0.0183450920777108 0.878925505400166 1 12.4 12 4 decreased transitional stage T1 B cell number 0.00342301478493311 0.0183450920777108 0.878925505400166 1 12.4 12 4 prolonged RR interval 0.00342301478493311 0.0183450920777108 0.878925505400166 1 12.4 12 4 abnormal infrahyoid muscle connection 0.00342301478493311 0.0183450920777108 0.878925505400166 1 12.4 12 4 schistocytosis 0.00643292344687713 0.03086190371091 0.878925505400166 1 12.4 12 4 abnormal cecum morphology 0.00643292344687713 0.03086190371091 0.878925505400166 1 12.4 12 4 short ureter 0.00643292344687713 0.03086190371091 0.878925505400166 1 12.4 12 4 hypospadia 0.00643292344687713 0.03086190371091 0.878925505400166 1 12.4 12 4 colon polyps 0.00643292344687713 0.03086190371091 0.878925505400166 1 12.4 12 4 liver failure 0.00643292344687713 0.03086190371091 0.878925505400166 1 12.4 12 4 increased cardiac output 0.00643292344687713 0.03086190371091 0.878925505400166 1 12.4 12 4 abnormal ovary development 0.00643292344687713 0.03086190371091 0.878925505400166 1 12.4 12 4 elevated level of mitotic sister chromatid exchange 0.00643292344687713 0.03086190371091 0.878925505400166 1 12.4 12 4 binucleate 0.00643292344687713 0.03086190371091 0.878925505400166 1 12.4 12 4 lymph node inflammation 0.00643292344687713 0.03086190371091 0.878925505400166 1 12.4 12 4 abnormal extraembryonic tissue physiology 0.00643292344687713 0.03086190371091 0.878925505400166 1 12.4 12 4 thin stria vascularis 0.00643292344687713 0.03086190371091 0.878925505400166 1 12.4 12 4 abnormal kidney epithelium morphology 0.00643292344687713 0.03086190371091 0.878925505400166 1 12.4 12 4 accumulation of giant lysosomes in kidney/renal tubule cells 0.00643292344687713 0.03086190371091 0.878925505400166 1 12.4 12 4 abnormal NK cell morphology 0.00643292344687713 0.03086190371091 0.878925505400166 1 12.4 12 4 abnormal somite size 0.00643292344687713 0.03086190371091 0.878925505400166 1 12.4 12 4 decreased susceptibility to autoimmune disorder 0.00643292344687713 0.03086190371091 0.878925505400166 1 12.4 12 4 abnormal meiotic spindle morphology 0.00643292344687713 0.03086190371091 0.878925505400166 1 12.4 12 4 abnormal sphingomyelin level 0.00643292344687713 0.03086190371091 0.878925505400166 1 12.4 12 4 skin fibrosis 0.00643292344687713 0.03086190371091 0.878925505400166 1 12.4 12 4 ostium secundum atrial septal defect 0.00643292344687713 0.03086190371091 0.878925505400166 1 12.4 12 4 pulmonary artery hypoplasia 0.00643292344687713 0.03086190371091 0.878925505400166 1 12.4 12 4 delayed suture closure 0.00643292344687713 0.03086190371091 0.878925505400166 1 12.4 12 4 increased susceptibility to parasitic infection induced morbidity/mortality 0.00643292344687713 0.03086190371091 0.878925505400166 1 12.4 12 4 increased aorta wall thickness 0.00643292344687713 0.03086190371091 0.878925505400166 1 12.4 12 4 abnormal macrophage activation involved in immune response 0.00643292344687713 0.03086190371091 0.878925505400166 1 12.4 12 4 lethality during fetal growth through weaning, incomplete penetrance 0.00643292344687713 0.03086190371091 0.878925505400166 1 12.4 12 4 increased cardiac stroke volume 0.00643292344687713 0.03086190371091 0.878925505400166 1 12.4 12 4 small thymus medulla 0.00643292344687713 0.03086190371091 0.878925505400166 1 12.4 12 4 abnormal umbilical vein topology 0.00643292344687713 0.03086190371091 0.878925505400166 1 12.4 12 4 decreased white adipose tissue mass 0.00643292344687713 0.03086190371091 0.878925505400166 1 12.4 12 4 decreased vascular endothelial cell proliferation 0.00643292344687713 0.03086190371091 0.878925505400166 1 12.4 12 4 broad head 0.0120891768920507 0.0520408893966227 0.878925505400166 1 12.4 12 4 polyphalangy 0.0120891768920507 0.0520408893966227 0.878925505400166 1 12.4 12 4 mammary gland hyperplasia 0.0120891768920507 0.0520408893966227 0.878925505400166 1 12.4 12 4 retina hyperplasia 0.0120891768920507 0.0520408893966227 0.878925505400166 1 12.4 12 4 excessive tearing 0.0120891768920507 0.0520408893966227 0.878925505400166 1 12.4 12 4 abnormal circulating free fatty acids level 0.0120891768920507 0.0520408893966227 0.878925505400166 1 12.4 12 4 abnormal circulating alanine transaminase level 0.0120891768920507 0.0520408893966227 0.878925505400166 1 12.4 12 4 decreased activated T cell number 0.0120891768920507 0.0520408893966227 0.878925505400166 1 12.4 12 4 abnormal hypersensitivity reaction 0.0120891768920507 0.0520408893966227 0.878925505400166 1 12.4 12 4 abnormal sinus venosus morphology 0.0120891768920507 0.0520408893966227 0.878925505400166 1 12.4 12 4 abnormal neurotransmitter uptake 0.0120891768920507 0.0520408893966227 0.878925505400166 1 12.4 12 4 increased cell nucleus count 0.0120891768920507 0.0520408893966227 0.878925505400166 1 12.4 12 4 abnormal strial marginal cell morphology 0.0120891768920507 0.0520408893966227 0.878925505400166 1 12.4 12 4 absent endocochlear potential 0.0120891768920507 0.0520408893966227 0.878925505400166 1 12.4 12 4 abnormal negative T cell selection 0.0120891768920507 0.0520408893966227 0.878925505400166 1 12.4 12 4 abnormal MHC II cell surface expression on macrophages 0.0120891768920507 0.0520408893966227 0.878925505400166 1 12.4 12 4 increased chronic myelocytic leukemia incidence 0.0120891768920507 0.0520408893966227 0.878925505400166 1 12.4 12 4 decreased tidal volume 0.0120891768920507 0.0520408893966227 0.878925505400166 1 12.4 12 4 increased keratinocyte apoptosis 0.0120891768920507 0.0520408893966227 0.878925505400166 1 12.4 12 4 heart hemorrhage 0.0120891768920507 0.0520408893966227 0.878925505400166 1 12.4 12 4 decreased DN2 thymocyte number 0.0120891768920507 0.0520408893966227 0.878925505400166 1 12.4 12 4 increased DN3 thymocyte number 0.0120891768920507 0.0520408893966227 0.878925505400166 1 12.4 12 4 decreased DN4 thymocyte number 0.0120891768920507 0.0520408893966227 0.878925505400166 1 12.4 12 4 decreased brain cholesterol level 0.0120891768920507 0.0520408893966227 0.878925505400166 1 12.4 12 4 abnormal T wave 0.0120891768920507 0.0520408893966227 0.878925505400166 1 12.4 12 4 abnormal aortic valve cusp morphology 0.0120891768920507 0.0520408893966227 0.878925505400166 1 12.4 12 4 altered tumor pathology 0.0120891768920507 0.0520408893966227 0.878925505400166 1 12.4 12 4 increased circulating lactate dehydrogenase level 0.0120891768920507 0.0520408893966227 0.878925505400166 1 12.4 12 4 decreased CD8-positive, naive alpha-beta T cell number 0.0120891768920507 0.0520408893966227 0.878925505400166 1 12.4 12 4 ductus venosus stenosis 0.0120891768920507 0.0520408893966227 0.878925505400166 1 12.4 12 4 absent connection between subcutaneous lymph vessels and lymph sac 0.0120891768920507 0.0520408893966227 0.878925505400166 1 12.4 12 4 echinocytosis 0.0227181950149358 0.0832888873981619 0.878925505400166 1 12.4 12 4 ectopic digits 0.0227181950149358 0.0832888873981619 0.878925505400166 1 12.4 12 4 thin tail 0.0227181950149358 0.0832888873981619 0.878925505400166 1 12.4 12 4 epidermal necrosis 0.0227181950149358 0.0832888873981619 0.878925505400166 1 12.4 12 4 absent ectoplacental cone 0.0227181950149358 0.0832888873981619 0.878925505400166 1 12.4 12 4 delayed brain development 0.0227181950149358 0.0832888873981619 0.878925505400166 1 12.4 12 4 non-obstructive hydrocephaly 0.0227181950149358 0.0832888873981619 0.878925505400166 1 12.4 12 4 abnormal gustatory system physiology 0.0227181950149358 0.0832888873981619 0.878925505400166 1 12.4 12 4 abnormal internal nares morphology 0.0227181950149358 0.0832888873981619 0.878925505400166 1 12.4 12 4 abnormal blood gas level 0.0227181950149358 0.0832888873981619 0.878925505400166 1 12.4 12 4 abnormal pulmonary ventilation 0.0227181950149358 0.0832888873981619 0.878925505400166 1 12.4 12 4 abnormal lymph node cortex morphology 0.0227181950149358 0.0832888873981619 0.878925505400166 1 12.4 12 4 abnormal cervical lymph node morphology 0.0227181950149358 0.0832888873981619 0.878925505400166 1 12.4 12 4 abnormal hippocampal fimbria morphology 0.0227181950149358 0.0832888873981619 0.878925505400166 1 12.4 12 4 ectopic thymus 0.0227181950149358 0.0832888873981619 0.878925505400166 1 12.4 12 4 bile duct inflammation 0.0227181950149358 0.0832888873981619 0.878925505400166 1 12.4 12 4 esophageal atresia 0.0227181950149358 0.0832888873981619 0.878925505400166 1 12.4 12 4 abnormal intestinal peristalsis 0.0227181950149358 0.0832888873981619 0.878925505400166 1 12.4 12 4 rheumatoid arthritis 0.0227181950149358 0.0832888873981619 0.878925505400166 1 12.4 12 4 ureter obstruction 0.0227181950149358 0.0832888873981619 0.878925505400166 1 12.4 12 4 abnormal leukocyte tethering or rolling 0.0227181950149358 0.0832888873981619 0.878925505400166 1 12.4 12 4 abnormal extensor digitorum longus morphology 0.0227181950149358 0.0832888873981619 0.878925505400166 1 12.4 12 4 abnormal physical strength 0.0227181950149358 0.0832888873981619 0.878925505400166 1 12.4 12 4 absent incus 0.0227181950149358 0.0832888873981619 0.878925505400166 1 12.4 12 4 vestibular saccular degeneration 0.0227181950149358 0.0832888873981619 0.878925505400166 1 12.4 12 4 bowed humerus 0.0227181950149358 0.0832888873981619 0.878925505400166 1 12.4 12 4 absent cochlear nerve compound action potential 0.0227181950149358 0.0832888873981619 0.878925505400166 1 12.4 12 4 absent parietal bone 0.0227181950149358 0.0832888873981619 0.878925505400166 1 12.4 12 4 decreased prostate gland weight 0.0227181950149358 0.0832888873981619 0.878925505400166 1 12.4 12 4 abnormal T cell clonal deletion 0.0227181950149358 0.0832888873981619 0.878925505400166 1 12.4 12 4 abnormal immature B cell morphology 0.0227181950149358 0.0832888873981619 0.878925505400166 1 12.4 12 4 impaired granulocyte bactericidal activity 0.0227181950149358 0.0832888873981619 0.878925505400166 1 12.4 12 4 osteomyelitis 0.0227181950149358 0.0832888873981619 0.878925505400166 1 12.4 12 4 abnormal heart size 0.0227181950149358 0.0832888873981619 0.878925505400166 1 12.4 12 4 abnormal ligament morphology 0.0227181950149358 0.0832888873981619 0.878925505400166 1 12.4 12 4 abnormal right lung morphology 0.0227181950149358 0.0832888873981619 0.878925505400166 1 12.4 12 4 abnormal eyelid development 0.0227181950149358 0.0832888873981619 0.878925505400166 1 12.4 12 4 increased transitional stage T1 B cell number 0.0227181950149358 0.0832888873981619 0.878925505400166 1 12.4 12 4 variable depigmentation 0.0227181950149358 0.0832888873981619 0.878925505400166 1 12.4 12 4 abnormal orbit morphology 0.0227181950149358 0.0832888873981619 0.878925505400166 1 12.4 12 4 increased erythrocyte clearance 0.0227181950149358 0.0832888873981619 0.878925505400166 1 12.4 12 4 abnormal oval cell physiology 0.0227181950149358 0.0832888873981619 0.878925505400166 1 12.4 12 4 abnormal acute phase protein level 0.0227181950149358 0.0832888873981619 0.878925505400166 1 12.4 12 4 kidney microaneurysm 0.0227181950149358 0.0832888873981619 0.878925505400166 1 12.4 12 4 cerebral arteriovenous malformation 0.0227181950149358 0.0832888873981619 0.878925505400166 1 12.4 12 4 common truncal valve 0.0227181950149358 0.0832888873981619 0.878925505400166 1 12.4 12 4 thick pulmonary valve cusps 0.0227181950149358 0.0832888873981619 0.878925505400166 1 12.4 12 4 absent third pharyngeal arch 0.0227181950149358 0.0832888873981619 0.878925505400166 1 12.4 12 4 thick myocardium 0.0227181950149358 0.0832888873981619 0.878925505400166 1 12.4 12 4 abnormal mandibular prominence morphology 0.0227181950149358 0.0832888873981619 0.878925505400166 1 12.4 12 4 decreased macrophage nitric oxide production 0.0227181950149358 0.0832888873981619 0.878925505400166 1 12.4 12 4 delayed limb development 0.0227181950149358 0.0832888873981619 0.878925505400166 1 12.4 12 4 thymus cortex atrophy 0.0227181950149358 0.0832888873981619 0.878925505400166 1 12.4 12 4 increased bone trabecular spacing 0.0227181950149358 0.0832888873981619 0.878925505400166 1 12.4 12 4 abnormal vertebral artery origin 0.0227181950149358 0.0832888873981619 0.878925505400166 1 12.4 12 4 additional anastomosis between intracranial vertebral arteries 0.0227181950149358 0.0832888873981619 0.878925505400166 1 12.4 12 4 ectopic bone 0.0227181950149358 0.0832888873981619 0.878925505400166 1 12.4 12 4 increased cardiac cell glucose uptake 0.0227181950149358 0.0832888873981619 0.878925505400166 1 12.4 12 4 decreased neuron apoptosis 1.32108600846922e-09 3.5719580935513e-08 0.855795886837004 0.973684210526316 12.4 12 4 increased fibroblast apoptosis 4.9465669492571e-08 1.0044559417369e-06 0.851459083356411 0.96875 12.4 12 4 increased thymocyte apoptosis 1.78975820115812e-06 2.62656255184709e-05 0.845120678269391 0.961538461538462 12.4 12 4 abnormal truncus arteriosus septation 5.85962704560859e-06 7.79455736681891e-05 0.842303609341826 0.958333333333333 12.4 12 4 increased activated T cell number 1.90608683767894e-05 0.000217994988906959 0.838974346063795 0.954545454545455 12.4 12 4 increased myocardial infarction size 1.90608683767894e-05 0.000217994988906959 0.838974346063795 0.954545454545455 12.4 12 4 abnormal erythropoiesis 8.30228255681919e-22 1.33238244258631e-19 0.83707190990492 0.952380952380952 12.4 12 4 abnormal cytotoxic T cell physiology 2.1624903627757e-09 5.51712284862007e-08 0.83707190990492 0.952380952380952 12.4 12 4 abnormal clavicle morphology 3.42828672026169e-05 0.000368374221021639 0.83707190990492 0.952380952380952 12.4 12 4 abnormal metatarsal bone morphology 0.000110195796145224 0.00102090146335659 0.832666268273842 0.947368421052632 12.4 12 4 spleen hyperplasia 2.09227643427102e-15 1.38787670139977e-13 0.832049478445491 0.946666666666667 12.4 12 4 abnormal chromosome morphology 3.96520274322583e-08 8.21953485314521e-07 0.831416018621779 0.945945945945946 12.4 12 4 abnormal head morphology 1.58810749755206e-11 6.27050380977896e-10 0.830984114196521 0.945454545454545 12.4 12 4 abnormal pharyngeal arch morphology 7.06610021575043e-08 1.40615394293434e-06 0.830096310655712 0.944444444444444 12.4 12 4 abnormal mitral valve morphology 0.000196849034527423 0.00167692456639371 0.830096310655712 0.944444444444444 12.4 12 4 underdeveloped hair follicles 0.000196849034527423 0.00167692456639371 0.830096310655712 0.944444444444444 12.4 12 4 decreased cellular sensitivity to gamma-irradiation 0.000196849034527423 0.00167692456639371 0.830096310655712 0.944444444444444 12.4 12 4 absent inner cell mass 0.000196849034527423 0.00167692456639371 0.830096310655712 0.944444444444444 12.4 12 4 increased effector memory CD4-positive, alpha-beta T cell number 0.000196849034527423 0.00167692456639371 0.830096310655712 0.944444444444444 12.4 12 4 abnormal hypoglossal nerve topology 0.000196849034527423 0.00167692456639371 0.830096310655712 0.944444444444444 12.4 12 4 impaired hematopoiesis 1.58717939289181e-10 5.16092645727892e-09 0.827224005082509 0.941176470588235 12.4 12 4 decreased cytotoxic T cell cytolysis 2.23360186568745e-07 3.95450864120821e-06 0.827224005082509 0.941176470588235 12.4 12 4 abnormal adipose tissue morphology 0.000350673464035021 0.00276920711678449 0.827224005082509 0.941176470588235 12.4 12 4 abnormal bone marrow cavity morphology 0.000350673464035021 0.00276920711678449 0.827224005082509 0.941176470588235 12.4 12 4 aminoaciduria 0.000350673464035021 0.00276920711678449 0.827224005082509 0.941176470588235 12.4 12 4 increased regulatory T cell number 0.000350673464035021 0.00276920711678449 0.827224005082509 0.941176470588235 12.4 12 4 increased B cell derived lymphoma incidence 2.81410551021871e-10 8.53669202032809e-09 0.826189975076156 0.94 12.4 12 4 abnormal embryonic hematopoiesis 7.01296704810369e-07 1.13646615844677e-05 0.823992661312656 0.9375 12.4 12 4 abnormal mouth morphology 0.000622786412062365 0.00447740231215356 0.823992661312656 0.9375 12.4 12 4 disorganized yolk sac vascular plexus 0.000622786412062365 0.00447740231215356 0.823992661312656 0.9375 12.4 12 4 increased intestinal adenocarcinoma incidence 0.000622786412062365 0.00447740231215356 0.823992661312656 0.9375 12.4 12 4 decreased B cell proliferation 2.76366096885581e-15 1.74040674937438e-13 0.823297308855852 0.936708860759494 12.4 12 4 increased cellular sensitivity to gamma-irradiation 1.55681127381035e-09 4.14178400385375e-08 0.8228238773959 0.936170212765957 12.4 12 4 abnormal T cell proliferation 1.23919697927785e-06 1.85692920840582e-05 0.822220634084026 0.935483870967742 12.4 12 4 failure to gastrulate 2.74606327662881e-09 6.83083240061416e-08 0.821604276787112 0.934782608695652 12.4 12 4 abnormal B cell differentiation 3.65633835089991e-17 3.24826487423697e-15 0.820974373175979 0.934065934065934 12.4 12 4 arrested T cell differentiation 2.18526992375587e-06 3.15122257121318e-05 0.820330471706822 0.933333333333333 12.4 12 4 macrocytosis 0.0011022570886659 0.00731163868815045 0.820330471706822 0.933333333333333 12.4 12 4 abnormal pup retrieval 0.0011022570886659 0.00731163868815045 0.820330471706822 0.933333333333333 12.4 12 4 delayed intramembranous bone ossification 0.0011022570886659 0.00731163868815045 0.820330471706822 0.933333333333333 12.4 12 4 abnormal neurotransmitter secretion 0.0011022570886659 0.00731163868815045 0.820330471706822 0.933333333333333 12.4 12 4 heterochrony 0.0011022570886659 0.00731163868815045 0.820330471706822 0.933333333333333 12.4 12 4 decreased brown adipose tissue mass 0.0011022570886659 0.00731163868815045 0.820330471706822 0.933333333333333 12.4 12 4 increased B cell proliferation 1.97300753525039e-11 7.66852538114899e-10 0.819337335542528 0.932203389830508 12.4 12 4 abnormal myelopoiesis 8.50694352955933e-09 2.00578407865202e-07 0.818998766395609 0.931818181818182 12.4 12 4 abnormal parietal bone morphology 3.84537919571037e-06 5.22698401602707e-05 0.818309953303603 0.931034482758621 12.4 12 4 abnormal cell cycle 6.42797195602144e-21 8.88310013366852e-19 0.817782861546242 0.930434782608696 12.4 12 4 lymphoid hyperplasia 6.7511840233123e-06 8.67884767854746e-05 0.816145112157297 0.928571428571429 12.4 12 4 premature aging 6.7511840233123e-06 8.67884767854746e-05 0.816145112157297 0.928571428571429 12.4 12 4 subcutaneous edema 6.7511840233123e-06 8.67884767854746e-05 0.816145112157297 0.928571428571429 12.4 12 4 abnormal blood flow velocity 0.00194332125901392 0.0116202202687431 0.816145112157297 0.928571428571429 12.4 12 4 amyloid beta deposits 0.00194332125901392 0.0116202202687431 0.816145112157297 0.928571428571429 12.4 12 4 absent olfactory bulb 0.00194332125901392 0.0116202202687431 0.816145112157297 0.928571428571429 12.4 12 4 abnormal vascular endothelial cell migration 0.00194332125901392 0.0116202202687431 0.816145112157297 0.928571428571429 12.4 12 4 abnormal sagittal suture morphology 0.00194332125901392 0.0116202202687431 0.816145112157297 0.928571428571429 12.4 12 4 abnormal maternal decidual layer morphology 0.00194332125901392 0.0116202202687431 0.816145112157297 0.928571428571429 12.4 12 4 split sternum 0.00194332125901392 0.0116202202687431 0.816145112157297 0.928571428571429 12.4 12 4 abnormal positive T cell selection 0.00194332125901392 0.0116202202687431 0.816145112157297 0.928571428571429 12.4 12 4 abnormal viscerocranium morphology 0.00194332125901392 0.0116202202687431 0.816145112157297 0.928571428571429 12.4 12 4 testis degeneration 0.00194332125901392 0.0116202202687431 0.816145112157297 0.928571428571429 12.4 12 4 multiple persisting craniopharyngeal ducts 0.00194332125901392 0.0116202202687431 0.816145112157297 0.928571428571429 12.4 12 4 decreased response to antigen 0.00194332125901392 0.0116202202687431 0.816145112157297 0.928571428571429 12.4 12 4 abnormal atrioventricular cushion morphology 1.18238291610714e-05 0.000142429903332518 0.813819912407561 0.925925925925926 12.4 12 4 extramedullary hematopoiesis 9.85632922085405e-19 1.04330293348402e-16 0.812591504992606 0.924528301886792 12.4 12 4 decreased IgA level 9.9036760241464e-10 2.75255800112449e-08 0.811315851138615 0.923076923076923 12.4 12 4 decreased bone resorption 2.06536557885985e-05 0.000234059083253479 0.811315851138615 0.923076923076923 12.4 12 4 tight skin 0.00341110978885343 0.0183450920777108 0.811315851138615 0.923076923076923 12.4 12 4 abnormal grip strength 0.00341110978885343 0.0183450920777108 0.811315851138615 0.923076923076923 12.4 12 4 abnormal lung interstitium morphology 0.00341110978885343 0.0183450920777108 0.811315851138615 0.923076923076923 12.4 12 4 abnormal tail bud morphology 0.00341110978885343 0.0183450920777108 0.811315851138615 0.923076923076923 12.4 12 4 abnormal telomere length 0.00341110978885343 0.0183450920777108 0.811315851138615 0.923076923076923 12.4 12 4 abnormal vestibulocochlear ganglion morphology 0.00341110978885343 0.0183450920777108 0.811315851138615 0.923076923076923 12.4 12 4 absent hypoglossal nerve 0.00341110978885343 0.0183450920777108 0.811315851138615 0.923076923076923 12.4 12 4 abnormal osteoclast physiology 1.25393601740275e-11 5.11338662834316e-10 0.810259450290778 0.921875 12.4 12 4 decreased hair follicle number 2.43034555052244e-07 4.28757769994651e-06 0.809536649710679 0.921052631578947 12.4 12 4 abnormal thyroid gland morphology 3.59758247371302e-05 0.000382435316382955 0.808611464968153 0.92 12.4 12 4 spontaneous skin ulceration 3.59758247371302e-05 0.000382435316382955 0.808611464968153 0.92 12.4 12 4 abnormal egg cylinder morphology 3.59758247371302e-05 0.000382435316382955 0.808611464968153 0.92 12.4 12 4 increased pre-B cell number 3.59758247371302e-05 0.000382435316382955 0.808611464968153 0.92 12.4 12 4 abnormal T cell activation 4.84937439609571e-13 2.41256376205762e-11 0.807661275232585 0.918918918918919 12.4 12 4 increased erythroid progenitor cell number 4.22096049043626e-07 7.16698922864176e-06 0.807661275232585 0.918918918918919 12.4 12 4 increased double-negative T cell number 6.55040620984816e-11 2.26307436763851e-09 0.806882431187038 0.918032786885246 12.4 12 4 curly tail 8.98646806539453e-09 2.07942691280641e-07 0.805681713283486 0.916666666666667 12.4 12 4 abnormal lysosome morphology 7.31488372531322e-07 1.1739208559172e-05 0.805681713283486 0.916666666666667 12.4 12 4 abnormal malleus morphology 6.2474671782623e-05 0.000616689468489185 0.805681713283486 0.916666666666667 12.4 12 4 decreased body height 6.2474671782623e-05 0.000616689468489185 0.805681713283486 0.916666666666667 12.4 12 4 decreased metastatic potential 6.2474671782623e-05 0.000616689468489185 0.805681713283486 0.916666666666667 12.4 12 4 ocular hypertelorism 6.2474671782623e-05 0.000616689468489185 0.805681713283486 0.916666666666667 12.4 12 4 hemolytic anemia 6.2474671782623e-05 0.000616689468489185 0.805681713283486 0.916666666666667 12.4 12 4 prolonged QT interval 6.2474671782623e-05 0.000616689468489185 0.805681713283486 0.916666666666667 12.4 12 4 abnormal tumor morphology 6.2474671782623e-05 0.000616689468489185 0.805681713283486 0.916666666666667 12.4 12 4 abnormal cellular extravasation 6.2474671782623e-05 0.000616689468489185 0.805681713283486 0.916666666666667 12.4 12 4 amyloidosis 0.00595740739481089 0.0296084932958883 0.805681713283486 0.916666666666667 12.4 12 4 abnormal respiratory function 0.00595740739481089 0.0296084932958883 0.805681713283486 0.916666666666667 12.4 12 4 decreased synaptic depression 0.00595740739481089 0.0296084932958883 0.805681713283486 0.916666666666667 12.4 12 4 abnormal aorta elastic fiber morphology 0.00595740739481089 0.0296084932958883 0.805681713283486 0.916666666666667 12.4 12 4 loss of dopaminergic neurons 0.00595740739481089 0.0296084932958883 0.805681713283486 0.916666666666667 12.4 12 4 small intestinal inflammation 0.00595740739481089 0.0296084932958883 0.805681713283486 0.916666666666667 12.4 12 4 pale placenta 0.00595740739481089 0.0296084932958883 0.805681713283486 0.916666666666667 12.4 12 4 bowed ulna 0.00595740739481089 0.0296084932958883 0.805681713283486 0.916666666666667 12.4 12 4 abnormal B cell proliferation 0.00595740739481089 0.0296084932958883 0.805681713283486 0.916666666666667 12.4 12 4 hematuria 0.00595740739481089 0.0296084932958883 0.805681713283486 0.916666666666667 12.4 12 4 abnormal palatine bone morphology 0.00595740739481089 0.0296084932958883 0.805681713283486 0.916666666666667 12.4 12 4 abnormal fatty acid level 0.00595740739481089 0.0296084932958883 0.805681713283486 0.916666666666667 12.4 12 4 abnormal pulmonary valve cusp morphology 0.00595740739481089 0.0296084932958883 0.805681713283486 0.916666666666667 12.4 12 4 abnormal vitelline vein connection 0.00595740739481089 0.0296084932958883 0.805681713283486 0.916666666666667 12.4 12 4 abnormal CD4-positive, alpha-beta T cell physiology 2.51037247552145e-12 1.16720589399245e-10 0.804650110577617 0.915492957746479 12.4 12 4 neuron degeneration 1.55305223069271e-08 3.43022307441957e-07 0.804123334727812 0.914893617021277 12.4 12 4 increased circulating serum albumin level 1.26474937995637e-06 1.88952797756245e-05 0.803589033508723 0.914285714285714 12.4 12 4 abnormal cell death 2.6790470262053e-08 5.64756735397092e-07 0.80249720058276 0.91304347826087 12.4 12 4 abnormal lymphocyte physiology 2.6790470262053e-08 5.64756735397092e-07 0.80249720058276 0.91304347826087 12.4 12 4 embryonic lethality between implantation and placentation, complete penetrance 2.6790470262053e-08 5.64756735397092e-07 0.80249720058276 0.91304347826087 12.4 12 4 abnormal cranial nerve morphology 0.0001081357382093 0.00100556130390892 0.80249720058276 0.91304347826087 12.4 12 4 abnormal regulatory T cell physiology 0.0001081357382093 0.00100556130390892 0.80249720058276 0.91304347826087 12.4 12 4 abnormal chondrocyte physiology 0.0001081357382093 0.00100556130390892 0.80249720058276 0.91304347826087 12.4 12 4 abnormal basicranium morphology 0.0001081357382093 0.00100556130390892 0.80249720058276 0.91304347826087 12.4 12 4 decreased T cell proliferation 7.6667529317101e-24 1.58925399313574e-21 0.801722589385287 0.912162162162162 12.4 12 4 abnormal placenta morphology 2.86667953004241e-13 1.45527863897561e-11 0.801046030238126 0.911392405063291 12.4 12 4 abnormal myocardial trabeculae morphology 4.61250816350887e-08 9.44330375039368e-07 0.80079879380904 0.911111111111111 12.4 12 4 abnormal T-helper 2 physiology 1.71894303698241e-09 4.54879872818483e-08 0.799023186727424 0.909090909090909 12.4 12 4 osteoporosis 7.92536834138409e-08 1.55844693669509e-06 0.799023186727424 0.909090909090909 12.4 12 4 abnormal enterocyte morphology 0.000186502855460892 0.00161085365610753 0.799023186727424 0.909090909090909 12.4 12 4 intestinal inflammation 0.000186502855460892 0.00161085365610753 0.799023186727424 0.909090909090909 12.4 12 4 abnormal oogenesis 0.000186502855460892 0.00161085365610753 0.799023186727424 0.909090909090909 12.4 12 4 abnormal lysosome physiology 0.000186502855460892 0.00161085365610753 0.799023186727424 0.909090909090909 12.4 12 4 abnormal blood-brain barrier function 0.000186502855460892 0.00161085365610753 0.799023186727424 0.909090909090909 12.4 12 4 absent semicircular canals 0.0103438971359466 0.0463611605867877 0.799023186727424 0.909090909090909 12.4 12 4 premature suture closure 0.0103438971359466 0.0463611605867877 0.799023186727424 0.909090909090909 12.4 12 4 abnormal thrombopoiesis 0.0103438971359466 0.0463611605867877 0.799023186727424 0.909090909090909 12.4 12 4 decreased atrioventricular cushion size 0.0103438971359466 0.0463611605867877 0.799023186727424 0.909090909090909 12.4 12 4 abnormal hemoglobin 0.0103438971359466 0.0463611605867877 0.799023186727424 0.909090909090909 12.4 12 4 failure of somite differentiation 0.0103438971359466 0.0463611605867877 0.799023186727424 0.909090909090909 12.4 12 4 abnormal proximal-distal axis patterning 0.0103438971359466 0.0463611605867877 0.799023186727424 0.909090909090909 12.4 12 4 abnormal fear/anxiety-related behavior 0.0103438971359466 0.0463611605867877 0.799023186727424 0.909090909090909 12.4 12 4 decreased post-tetanic potentiation 0.0103438971359466 0.0463611605867877 0.799023186727424 0.909090909090909 12.4 12 4 fused joints 0.0103438971359466 0.0463611605867877 0.799023186727424 0.909090909090909 12.4 12 4 loss of cortex neurons 0.0103438971359466 0.0463611605867877 0.799023186727424 0.909090909090909 12.4 12 4 pulmonary hypertension 0.0103438971359466 0.0463611605867877 0.799023186727424 0.909090909090909 12.4 12 4 abnormal coronal suture morphology 0.0103438971359466 0.0463611605867877 0.799023186727424 0.909090909090909 12.4 12 4 pharyngeal arch hypoplasia 0.0103438971359466 0.0463611605867877 0.799023186727424 0.909090909090909 12.4 12 4 abnormal spinal cord ventral horn morphology 0.0103438971359466 0.0463611605867877 0.799023186727424 0.909090909090909 12.4 12 4 increased circulating triiodothyronine level 0.0103438971359466 0.0463611605867877 0.799023186727424 0.909090909090909 12.4 12 4 aorta dilation 0.0103438971359466 0.0463611605867877 0.799023186727424 0.909090909090909 12.4 12 4 abnormal brain ependyma motile cilium morphology 0.0103438971359466 0.0463611605867877 0.799023186727424 0.909090909090909 12.4 12 4 decreased embryonic cilium length 0.0103438971359466 0.0463611605867877 0.799023186727424 0.909090909090909 12.4 12 4 thin hypoglossal nerve 0.0103438971359466 0.0463611605867877 0.799023186727424 0.909090909090909 12.4 12 4 increased osteoblast cell number 3.75293220504274e-06 5.11529800550346e-05 0.799023186727424 0.909090909090909 12.4 12 4 decreased tumor growth/size 2.94642792276511e-09 7.22092557426424e-08 0.79754351415941 0.907407407407407 12.4 12 4 abnormal neuronal precursor proliferation 2.94642792276511e-09 7.22092557426424e-08 0.79754351415941 0.907407407407407 12.4 12 4 kidney failure 1.35890058568458e-07 2.49466066929179e-06 0.797164993269918 0.906976744186046 12.4 12 4 abnormal spongiotrophoblast layer morphology 6.43889963246352e-06 8.42987517671211e-05 0.796526239268901 0.90625 12.4 12 4 increased fatty acid level 6.43889963246352e-06 8.42987517671211e-05 0.796526239268901 0.90625 12.4 12 4 small ears 0.000320416946927628 0.00255870675917327 0.795218314409674 0.904761904761905 12.4 12 4 increased incidence of induced tumors 0.000320416946927628 0.00255870675917327 0.795218314409674 0.904761904761905 12.4 12 4 abnormal tumor vascularization 0.000320416946927628 0.00255870675917327 0.795218314409674 0.904761904761905 12.4 12 4 embryonic lethality at implantation, complete penetrance 0.000320416946927628 0.00255870675917327 0.795218314409674 0.904761904761905 12.4 12 4 absent segment of posterior cerebral artery 0.000320416946927628 0.00255870675917327 0.795218314409674 0.904761904761905 12.4 12 4 abnormal vitelline vasculature morphology 5.54047925982839e-18 5.40468319953848e-16 0.79485437010102 0.904347826086957 12.4 12 4 abnormal placenta vasculature 8.61025142166438e-09 2.02056607654624e-07 0.794413437573227 0.903846153846154 12.4 12 4 abnormal cell morphology 9.44851541616904e-18 9.03968542220018e-16 0.794116904001904 0.903508771929825 12.4 12 4 osteopetrosis 1.10152840722174e-05 0.000133661068925078 0.793868198425957 0.903225806451613 12.4 12 4 abnormal object recognition memory 1.10152840722174e-05 0.000133661068925078 0.793868198425957 0.903225806451613 12.4 12 4 pale kidney 1.10152840722174e-05 0.000133661068925078 0.793868198425957 0.903225806451613 12.4 12 4 liver fibrosis 3.96834560077371e-07 6.76113676844152e-06 0.793176675605028 0.902439024390244 12.4 12 4 increased neuron apoptosis 8.0433278143057e-13 3.88500542487096e-11 0.792118048076693 0.901234567901235 12.4 12 4 abnormal T cell differentiation 1.2000738631736e-15 8.17858557436805e-14 0.791903178132823 0.900990099009901 12.4 12 4 decreased double-positive T cell number 2.03880835589995e-15 1.37068534737868e-13 0.79103295486015 0.9 12.4 12 4 abnormal pericardium morphology 0.000548154374007248 0.00406418481473332 0.79103295486015 0.9 12.4 12 4 abnormal vascular regression 0.000548154374007248 0.00406418481473332 0.79103295486015 0.9 12.4 12 4 abnormal Peyer's patch T cell area morphology 0.000548154374007248 0.00406418481473332 0.79103295486015 0.9 12.4 12 4 abnormal optic stalk morphology 0.000548154374007248 0.00406418481473332 0.79103295486015 0.9 12.4 12 4 absent ductus venosus valve 0.000548154374007248 0.00406418481473332 0.79103295486015 0.9 12.4 12 4 abnormal auchene hair morphology 0.0178378281300291 0.0717406588091308 0.79103295486015 0.9 12.4 12 4 fused cornea and lens 0.0178378281300291 0.0717406588091308 0.79103295486015 0.9 12.4 12 4 abnormal respiratory mechanics 0.0178378281300291 0.0717406588091308 0.79103295486015 0.9 12.4 12 4 impaired basement membrane formation 0.0178378281300291 0.0717406588091308 0.79103295486015 0.9 12.4 12 4 abnormal scala media morphology 0.0178378281300291 0.0717406588091308 0.79103295486015 0.9 12.4 12 4 absent seminal vesicle 0.0178378281300291 0.0717406588091308 0.79103295486015 0.9 12.4 12 4 abnormal ear physiology 0.0178378281300291 0.0717406588091308 0.79103295486015 0.9 12.4 12 4 increased heart rate variability 0.0178378281300291 0.0717406588091308 0.79103295486015 0.9 12.4 12 4 abnormal gas homeostasis 0.0178378281300291 0.0717406588091308 0.79103295486015 0.9 12.4 12 4 abnormal embryonic erythrocyte morphology 0.0178378281300291 0.0717406588091308 0.79103295486015 0.9 12.4 12 4 abnormal respiratory conducting tube morphology 0.0178378281300291 0.0717406588091308 0.79103295486015 0.9 12.4 12 4 abnormal cochlear inner hair cell physiology 0.0178378281300291 0.0717406588091308 0.79103295486015 0.9 12.4 12 4 absent inguinal lymph nodes 0.0178378281300291 0.0717406588091308 0.79103295486015 0.9 12.4 12 4 protruding tongue 0.0178378281300291 0.0717406588091308 0.79103295486015 0.9 12.4 12 4 abnormal hippocampus neuron morphology 0.0178378281300291 0.0717406588091308 0.79103295486015 0.9 12.4 12 4 increased serotonin level 0.0178378281300291 0.0717406588091308 0.79103295486015 0.9 12.4 12 4 increased circulating fructosamine level 0.0178378281300291 0.0717406588091308 0.79103295486015 0.9 12.4 12 4 aorta stenosis 0.0178378281300291 0.0717406588091308 0.79103295486015 0.9 12.4 12 4 abnormal left subclavian artery morphology 0.0178378281300291 0.0717406588091308 0.79103295486015 0.9 12.4 12 4 abnormal pulmonary interalveolar septum morphology 0.0178378281300291 0.0717406588091308 0.79103295486015 0.9 12.4 12 4 decreased trabecular bone connectivity density 0.0178378281300291 0.0717406588091308 0.79103295486015 0.9 12.4 12 4 abnormal adaptive thermogenesis 0.0178378281300291 0.0717406588091308 0.79103295486015 0.9 12.4 12 4 increased T cell number 1.51504133901491e-13 8.19275071912952e-12 0.789035396893331 0.897727272727273 12.4 12 4 small liver 3.93044733281999e-12 1.74589066792674e-10 0.788779299718098 0.897435897435897 12.4 12 4 impaired macrophage chemotaxis 1.14769247397385e-06 1.74078355427437e-05 0.788779299718098 0.897435897435897 12.4 12 4 decreased cell proliferation 6.02261966556867e-27 1.60632071864827e-24 0.78865748052123 0.897297297297297 12.4 12 4 increased T cell proliferation 3.85805599026613e-16 2.95289670024215e-14 0.788568677742205 0.897196261682243 12.4 12 4 decreased IgM level 9.93117521626237e-15 5.95272249408497e-13 0.788314628554788 0.896907216494845 12.4 12 4 abnormal middle ear morphology 3.19348258625291e-05 0.000347649362507839 0.788002177255321 0.896551724137931 12.4 12 4 abnormal outer ear morphology 3.19348258625291e-05 0.000347649362507839 0.788002177255321 0.896551724137931 12.4 12 4 polychromatophilia 3.19348258625291e-05 0.000347649362507839 0.788002177255321 0.896551724137931 12.4 12 4 blood in lymph vessels 3.19348258625291e-05 0.000347649362507839 0.788002177255321 0.896551724137931 12.4 12 4 vertebral transformation 7.18093887841064e-08 1.42331358247382e-06 0.787370765254315 0.895833333333333 12.4 12 4 abnormal frontal bone morphology 1.94411874797038e-06 2.81162522417228e-05 0.786407031147517 0.894736842105263 12.4 12 4 decreased total retina thickness 1.94411874797038e-06 2.81162522417228e-05 0.786407031147517 0.894736842105263 12.4 12 4 small superior vagus ganglion 0.000933401560776115 0.00637426603062396 0.786407031147517 0.894736842105263 12.4 12 4 stereotypic behavior 0.000933401560776115 0.00637426603062396 0.786407031147517 0.894736842105263 12.4 12 4 abnormal sternebra morphology 0.000933401560776115 0.00637426603062396 0.786407031147517 0.894736842105263 12.4 12 4 abnormal blastocyst morphology 0.000933401560776115 0.00637426603062396 0.786407031147517 0.894736842105263 12.4 12 4 embryonic lethality between implantation and somite formation, complete penetrance 1.62229496136717e-34 7.33719766618332e-32 0.785651778296475 0.893877551020408 12.4 12 4 abnormal T-helper 1 physiology 1.21374033085111e-07 2.27005945337755e-06 0.785422792059723 0.893617021276596 12.4 12 4 small superior cervical ganglion 5.40958719757302e-05 0.000544791423237364 0.784754915535863 0.892857142857143 12.4 12 4 straub tail 5.40958719757302e-05 0.000544791423237364 0.784754915535863 0.892857142857143 12.4 12 4 failure of blastocyst to hatch from the zona pellucida 5.40958719757302e-05 0.000544791423237364 0.784754915535863 0.892857142857143 12.4 12 4 abnormal brainstem morphology 5.40958719757302e-05 0.000544791423237364 0.784754915535863 0.892857142857143 12.4 12 4 abnormal mitotic spindle morphology 5.40958719757302e-05 0.000544791423237364 0.784754915535863 0.892857142857143 12.4 12 4 abnormal definitive hematopoiesis 8.06732458297985e-14 4.5095437977893e-12 0.784417386539933 0.89247311827957 12.4 12 4 pale liver 3.1947747675626e-11 1.20409124762303e-09 0.783906531843391 0.891891891891892 12.4 12 4 decreased width of hypertrophic chondrocyte zone 3.28397504130479e-06 4.57256924276107e-05 0.783906531843391 0.891891891891892 12.4 12 4 pale yolk sac 2.07810200176977e-12 9.75335609321189e-11 0.783620330115811 0.891566265060241 12.4 12 4 abnormal inner ear morphology 2.0466889489398e-07 3.67173394843374e-06 0.783390124378409 0.891304347826087 12.4 12 4 decreased circulating total protein level 1.2970887823324e-08 2.93318940550167e-07 0.783042722992875 0.890909090909091 12.4 12 4 astrocytosis 5.37376257854387e-11 1.8695432747032e-09 0.782604902068641 0.89041095890411 12.4 12 4 abnormal apoptosis 2.1801787329214e-08 4.73641449619387e-07 0.781267115911259 0.888888888888889 12.4 12 4 abnormal cell adhesion 2.1801787329214e-08 4.73641449619387e-07 0.781267115911259 0.888888888888889 12.4 12 4 abnormal heart valve morphology 9.1292268808816e-05 0.000861819805168614 0.781267115911259 0.888888888888889 12.4 12 4 rectal prolapse 9.1292268808816e-05 0.000861819805168614 0.781267115911259 0.888888888888889 12.4 12 4 abnormal eye muscle morphology 9.1292268808816e-05 0.000861819805168614 0.781267115911259 0.888888888888889 12.4 12 4 thick interventricular septum 9.1292268808816e-05 0.000861819805168614 0.781267115911259 0.888888888888889 12.4 12 4 abnormal thymus cortex morphology 0.00158126890009581 0.00989536198487628 0.781267115911259 0.888888888888889 12.4 12 4 abnormal thymus medulla morphology 0.00158126890009581 0.00989536198487628 0.781267115911259 0.888888888888889 12.4 12 4 abnormal Peyer's patch follicle morphology 0.00158126890009581 0.00989536198487628 0.781267115911259 0.888888888888889 12.4 12 4 abnormal metacarpal bone morphology 0.00158126890009581 0.00989536198487628 0.781267115911259 0.888888888888889 12.4 12 4 abnormal neutrophil morphology 0.00158126890009581 0.00989536198487628 0.781267115911259 0.888888888888889 12.4 12 4 atrioventricular block 0.00158126890009581 0.00989536198487628 0.781267115911259 0.888888888888889 12.4 12 4 increased effector memory CD8-positive, alpha-beta T cell number 0.00158126890009581 0.00989536198487628 0.781267115911259 0.888888888888889 12.4 12 4 abnormal aerobic respiration 0.00158126890009581 0.00989536198487628 0.781267115911259 0.888888888888889 12.4 12 4 increased adipocyte glucose uptake 0.00158126890009581 0.00989536198487628 0.781267115911259 0.888888888888889 12.4 12 4 heart hyperplasia 0.0305121927424292 0.106004300903342 0.781267115911259 0.888888888888889 12.4 12 4 distorted hair follicle pattern 0.0305121927424292 0.106004300903342 0.781267115911259 0.888888888888889 12.4 12 4 crypts of Lieberkuhn abscesses 0.0305121927424292 0.106004300903342 0.781267115911259 0.888888888888889 12.4 12 4 renal tubular acidosis 0.0305121927424292 0.106004300903342 0.781267115911259 0.888888888888889 12.4 12 4 thick tail 0.0305121927424292 0.106004300903342 0.781267115911259 0.888888888888889 12.4 12 4 abnormal sympathetic neuron morphology 0.0305121927424292 0.106004300903342 0.781267115911259 0.888888888888889 12.4 12 4 psoriasis 0.0305121927424292 0.106004300903342 0.781267115911259 0.888888888888889 12.4 12 4 decreased level of surface class I molecules 0.0305121927424292 0.106004300903342 0.781267115911259 0.888888888888889 12.4 12 4 abnormal germ cell morphology 0.0305121927424292 0.106004300903342 0.781267115911259 0.888888888888889 12.4 12 4 abnormal NMDA-mediated synaptic currents 0.0305121927424292 0.106004300903342 0.781267115911259 0.888888888888889 12.4 12 4 abnormal abdominal wall morphology 0.0305121927424292 0.106004300903342 0.781267115911259 0.888888888888889 12.4 12 4 abnormal artery development 0.0305121927424292 0.106004300903342 0.781267115911259 0.888888888888889 12.4 12 4 decreased susceptibility to induced choroidal neovascularization 0.0305121927424292 0.106004300903342 0.781267115911259 0.888888888888889 12.4 12 4 abnormal thymus physiology 0.0305121927424292 0.106004300903342 0.781267115911259 0.888888888888889 12.4 12 4 decreased cochlear hair cell number 0.0305121927424292 0.106004300903342 0.781267115911259 0.888888888888889 12.4 12 4 increased neuronal precursor cell number 0.0305121927424292 0.106004300903342 0.781267115911259 0.888888888888889 12.4 12 4 positive geotaxis 0.0305121927424292 0.106004300903342 0.781267115911259 0.888888888888889 12.4 12 4 absent cervical lymph nodes 0.0305121927424292 0.106004300903342 0.781267115911259 0.888888888888889 12.4 12 4 abnormal optic chiasm morphology 0.0305121927424292 0.106004300903342 0.781267115911259 0.888888888888889 12.4 12 4 abnormal liver vasculature morphology 0.0305121927424292 0.106004300903342 0.781267115911259 0.888888888888889 12.4 12 4 eye opacity 0.0305121927424292 0.106004300903342 0.781267115911259 0.888888888888889 12.4 12 4 abnormal hippocampus granule cell morphology 0.0305121927424292 0.106004300903342 0.781267115911259 0.888888888888889 12.4 12 4 abnormal telomere morphology 0.0305121927424292 0.106004300903342 0.781267115911259 0.888888888888889 12.4 12 4 shortened ST segment 0.0305121927424292 0.106004300903342 0.781267115911259 0.888888888888889 12.4 12 4 decreased susceptibility to parasitic infection induced morbidity/mortality 0.0305121927424292 0.106004300903342 0.781267115911259 0.888888888888889 12.4 12 4 decreased effector memory CD4-positive, alpha-beta T cell number 0.0305121927424292 0.106004300903342 0.781267115911259 0.888888888888889 12.4 12 4 abnormal oxidative phosphorylation 0.0305121927424292 0.106004300903342 0.781267115911259 0.888888888888889 12.4 12 4 reduced AMPA-mediated synaptic currents 0.0305121927424292 0.106004300903342 0.781267115911259 0.888888888888889 12.4 12 4 increased myeloid cell number 0.0305121927424292 0.106004300903342 0.781267115911259 0.888888888888889 12.4 12 4 abnormal ductus venosus valve topology 0.0305121927424292 0.106004300903342 0.781267115911259 0.888888888888889 12.4 12 4 symmetric azygos veins 0.0305121927424292 0.106004300903342 0.781267115911259 0.888888888888889 12.4 12 4 increased cardiac muscle glycogen level 0.0305121927424292 0.106004300903342 0.781267115911259 0.888888888888889 12.4 12 4 decreased fatty acid oxidation 0.0305121927424292 0.106004300903342 0.781267115911259 0.888888888888889 12.4 12 4 enhanced leukocyte tethering or rolling 0.0305121927424292 0.106004300903342 0.781267115911259 0.888888888888889 12.4 12 4 decreased platelet dense granule number 0.0305121927424292 0.106004300903342 0.781267115911259 0.888888888888889 12.4 12 4 domed cranium 2.53224452894934e-10 7.77649168612528e-09 0.778476876211576 0.885714285714286 12.4 12 4 embryonic lethality between somite formation and embryo turning, complete penetrance 2.53224452894934e-10 7.77649168612528e-09 0.778476876211576 0.885714285714286 12.4 12 4 decreased triglyceride level 9.28591328613819e-06 0.000114350046035984 0.778476876211576 0.885714285714286 12.4 12 4 decreased glycogen level 9.28591328613819e-06 0.000114350046035984 0.778476876211576 0.885714285714286 12.4 12 4 abnormal hippocampus pyramidal cell morphology 9.28591328613819e-06 0.000114350046035984 0.778476876211576 0.885714285714286 12.4 12 4 abnormal embryo size 8.52886253415487e-16 6.14943349382905e-14 0.777810181770058 0.884955752212389 12.4 12 4 increased embryonic tissue cell apoptosis 2.75107590595173e-11 1.04477882687862e-09 0.777511024007839 0.884615384615385 12.4 12 4 abnormal leukocyte migration 6.11899461548826e-08 1.22749992790541e-06 0.777511024007839 0.884615384615385 12.4 12 4 kinked neural tube 6.11899461548826e-08 1.22749992790541e-06 0.777511024007839 0.884615384615385 12.4 12 4 abnormal nasal bone morphology 0.000153445786675873 0.00136564005136399 0.777511024007839 0.884615384615385 12.4 12 4 heart inflammation 0.000153445786675873 0.00136564005136399 0.777511024007839 0.884615384615385 12.4 12 4 increased leukemia incidence 0.000153445786675873 0.00136564005136399 0.777511024007839 0.884615384615385 12.4 12 4 abnormal erythrocyte osmotic lysis 0.000153445786675873 0.00136564005136399 0.777511024007839 0.884615384615385 12.4 12 4 abnormal Mullerian duct morphology 0.000153445786675873 0.00136564005136399 0.777511024007839 0.884615384615385 12.4 12 4 decreased Peyer's patch number 0.000153445786675873 0.00136564005136399 0.777511024007839 0.884615384615385 12.4 12 4 abnormal double-strand DNA break repair 9.66627518055931e-07 1.48884579019451e-05 0.776724865237356 0.883720930232558 12.4 12 4 decreased B cell number 1.99036390620922e-27 6.60137362226059e-25 0.77652641739238 0.883495145631068 12.4 12 4 abnormal hepatocyte morphology 2.37354339945413e-15 1.533555637959e-13 0.775988284046993 0.882882882882883 12.4 12 4 decreased IgG level 2.37354339945413e-15 1.533555637959e-13 0.775988284046993 0.882882882882883 12.4 12 4 abnormal dendritic spine morphology 1.02157889271356e-07 1.95475191971152e-06 0.775522504764852 0.882352941176471 12.4 12 4 abnormal spleen red pulp morphology 1.55390200450346e-05 0.000180622954962727 0.775522504764852 0.882352941176471 12.4 12 4 decreased regulatory T cell number 1.55390200450346e-05 0.000180622954962727 0.775522504764852 0.882352941176471 12.4 12 4 abnormal interatrial septum morphology 0.00266363352226745 0.0152492252857084 0.775522504764852 0.882352941176471 12.4 12 4 hyperlipidemia 0.00266363352226745 0.0152492252857084 0.775522504764852 0.882352941176471 12.4 12 4 abnormal cranial suture morphology 0.00266363352226745 0.0152492252857084 0.775522504764852 0.882352941176471 12.4 12 4 abnormal testis development 0.00266363352226745 0.0152492252857084 0.775522504764852 0.882352941176471 12.4 12 4 abnormal embryonic-extraembryonic boundary morphology 0.00266363352226745 0.0152492252857084 0.775522504764852 0.882352941176471 12.4 12 4 abnormal tarsal bone morphology 0.00266363352226745 0.0152492252857084 0.775522504764852 0.882352941176471 12.4 12 4 pancytopenia 0.00266363352226745 0.0152492252857084 0.775522504764852 0.882352941176471 12.4 12 4 coloboma 0.00266363352226745 0.0152492252857084 0.775522504764852 0.882352941176471 12.4 12 4 increased hepatoma incidence 0.00266363352226745 0.0152492252857084 0.775522504764852 0.882352941176471 12.4 12 4 increased trabecular bone mass 0.00266363352226745 0.0152492252857084 0.775522504764852 0.882352941176471 12.4 12 4 abnormal spleen white pulp morphology 1.61300326656807e-06 2.38121402112052e-05 0.774291516662051 0.880952380952381 12.4 12 4 spina bifida 1.61300326656807e-06 2.38121402112052e-05 0.774291516662051 0.880952380952381 12.4 12 4 embryonic lethality before implantation, complete penetrance 7.96111656154022e-17 6.71297540570553e-15 0.773454444752146 0.88 12.4 12 4 increased cellular sensitivity to ionizing radiation 0.000256799550116238 0.00212369248627557 0.773454444752146 0.88 12.4 12 4 abnormal vertebrae development 0.000256799550116238 0.00212369248627557 0.773454444752146 0.88 12.4 12 4 decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 0.000256799550116238 0.00212369248627557 0.773454444752146 0.88 12.4 12 4 decreased hemoglobin content 9.6805585388795e-19 1.04330293348402e-16 0.772955763614331 0.879432624113475 12.4 12 4 decreased erythrocyte cell number 1.18013200219392e-20 1.46778917772869e-18 0.772558724491866 0.878980891719745 12.4 12 4 abnormal vascular development 1.95137958794544e-09 5.08278191100971e-08 0.772389080503176 0.878787878787879 12.4 12 4 decreased brown adipose tissue amount 2.59121634812641e-05 0.000286473362931753 0.772389080503176 0.878787878787879 12.4 12 4 abnormal QRS complex 2.59121634812641e-05 0.000286473362931753 0.772389080503176 0.878787878787879 12.4 12 4 abnormal T cell subpopulation ratio 2.59121634812641e-05 0.000286473362931753 0.772389080503176 0.878787878787879 12.4 12 4 myeloid hyperplasia 2.59121634812641e-05 0.000286473362931753 0.772389080503176 0.878787878787879 12.4 12 4 enlarged spleen 1.25319056688281e-36 6.23462307024198e-34 0.772111641896674 0.878472222222222 12.4 12 4 arrested B cell differentiation 2.68372308230528e-06 3.79304611774681e-05 0.771739468156244 0.878048780487805 12.4 12 4 increased T cell derived lymphoma incidence 2.82650795749267e-07 4.93399196088633e-06 0.771301974126676 0.877551020408163 12.4 12 4 increased hepatocellular carcinoma incidence 3.01153458037313e-08 6.32168123939086e-07 0.770987285438742 0.87719298245614 12.4 12 4 hydrops fetalis 5.78675103776767e-10 1.68357230484761e-08 0.769059817225145 0.875 12.4 12 4 overriding aortic valve 4.68326543192135e-07 7.84486381273021e-06 0.769059817225145 0.875 12.4 12 4 bradykinesia 4.30499751504948e-05 0.000449944593222083 0.769059817225145 0.875 12.4 12 4 abnormal nursing 0.00042776320319604 0.00326900450983149 0.769059817225145 0.875 12.4 12 4 abnormal impulse conducting system conduction 0.00042776320319604 0.00326900450983149 0.769059817225145 0.875 12.4 12 4 increased hemangiosarcoma incidence 0.00042776320319604 0.00326900450983149 0.769059817225145 0.875 12.4 12 4 abnormal inner cell mass apoptosis 0.00042776320319604 0.00326900450983149 0.769059817225145 0.875 12.4 12 4 failure of tooth eruption 0.0044585518248906 0.0234474580643031 0.769059817225145 0.875 12.4 12 4 decreased mast cell number 0.0044585518248906 0.0234474580643031 0.769059817225145 0.875 12.4 12 4 intraventricular hemorrhage 0.0044585518248906 0.0234474580643031 0.769059817225145 0.875 12.4 12 4 abnormal pulmonary elastic fiber morphology 0.0044585518248906 0.0234474580643031 0.769059817225145 0.875 12.4 12 4 decreased aggression towards mice 0.0044585518248906 0.0234474580643031 0.769059817225145 0.875 12.4 12 4 bowed radius 0.0044585518248906 0.0234474580643031 0.769059817225145 0.875 12.4 12 4 increased cochlear outer hair cell number 0.0044585518248906 0.0234474580643031 0.769059817225145 0.875 12.4 12 4 abnormal amnion morphology 0.0044585518248906 0.0234474580643031 0.769059817225145 0.875 12.4 12 4 sepsis 0.0044585518248906 0.0234474580643031 0.769059817225145 0.875 12.4 12 4 kidney degeneration 0.0044585518248906 0.0234474580643031 0.769059817225145 0.875 12.4 12 4 impaired somite development 0.0044585518248906 0.0234474580643031 0.769059817225145 0.875 12.4 12 4 decreased liver cholesterol level 0.0044585518248906 0.0234474580643031 0.769059817225145 0.875 12.4 12 4 abnormal thoracic cage shape 0.0044585518248906 0.0234474580643031 0.769059817225145 0.875 12.4 12 4 decreased fibroblast apoptosis 0.0044585518248906 0.0234474580643031 0.769059817225145 0.875 12.4 12 4 abnormal exoccipital bone morphology 0.0516829510082659 0.15479992851663 0.769059817225145 0.875 12.4 12 4 abnormal bone marrow development 0.0516829510082659 0.15479992851663 0.769059817225145 0.875 12.4 12 4 failure of vascular branching 0.0516829510082659 0.15479992851663 0.769059817225145 0.875 12.4 12 4 abnormal vagus ganglion morphology 0.0516829510082659 0.15479992851663 0.769059817225145 0.875 12.4 12 4 increased sensitivity to skin irradiation 0.0516829510082659 0.15479992851663 0.769059817225145 0.875 12.4 12 4 abnormal pupil morphology 0.0516829510082659 0.15479992851663 0.769059817225145 0.875 12.4 12 4 dry eyes 0.0516829510082659 0.15479992851663 0.769059817225145 0.875 12.4 12 4 abnormal erythrocyte cell number 0.0516829510082659 0.15479992851663 0.769059817225145 0.875 12.4 12 4 abnormal urination 0.0516829510082659 0.15479992851663 0.769059817225145 0.875 12.4 12 4 abnormal hepatobiliary system morphology 0.0516829510082659 0.15479992851663 0.769059817225145 0.875 12.4 12 4 abnormal pulmonary circulation 0.0516829510082659 0.15479992851663 0.769059817225145 0.875 12.4 12 4 head spot 0.0516829510082659 0.15479992851663 0.769059817225145 0.875 12.4 12 4 decreased aerobic running capacity 0.0516829510082659 0.15479992851663 0.769059817225145 0.875 12.4 12 4 absent tympanic ring 0.0516829510082659 0.15479992851663 0.769059817225145 0.875 12.4 12 4 abnormal soft palate morphology 0.0516829510082659 0.15479992851663 0.769059817225145 0.875 12.4 12 4 abnormal cellular cholesterol metabolism 0.0516829510082659 0.15479992851663 0.769059817225145 0.875 12.4 12 4 abnormal eyelid aperture 0.0516829510082659 0.15479992851663 0.769059817225145 0.875 12.4 12 4 tau protein deposits 0.0516829510082659 0.15479992851663 0.769059817225145 0.875 12.4 12 4 abnormal lateral ganglionic eminence morphology 0.0516829510082659 0.15479992851663 0.769059817225145 0.875 12.4 12 4 abnormal choroid pigmentation 0.0516829510082659 0.15479992851663 0.769059817225145 0.875 12.4 12 4 abnormal vertebral body development 0.0516829510082659 0.15479992851663 0.769059817225145 0.875 12.4 12 4 Sertoli cell hypoplasia 0.0516829510082659 0.15479992851663 0.769059817225145 0.875 12.4 12 4 craniofacial phenotype 0.0516829510082659 0.15479992851663 0.769059817225145 0.875 12.4 12 4 absent outer ear 0.0516829510082659 0.15479992851663 0.769059817225145 0.875 12.4 12 4 abnormal epidermal lamellar body morphology 0.0516829510082659 0.15479992851663 0.769059817225145 0.875 12.4 12 4 enlarged inguinal lymph nodes 0.0516829510082659 0.15479992851663 0.769059817225145 0.875 12.4 12 4 abnormal mitotic spindle assembly checkpoint 0.0516829510082659 0.15479992851663 0.769059817225145 0.875 12.4 12 4 abnormal base-excision repair 0.0516829510082659 0.15479992851663 0.769059817225145 0.875 12.4 12 4 abnormal cerebellum deep nucleus morphology 0.0516829510082659 0.15479992851663 0.769059817225145 0.875 12.4 12 4 increased caudal vertebrae number 0.0516829510082659 0.15479992851663 0.769059817225145 0.875 12.4 12 4 abnormal circulating serum amyloid protein level 0.0516829510082659 0.15479992851663 0.769059817225145 0.875 12.4 12 4 pleural effusion 0.0516829510082659 0.15479992851663 0.769059817225145 0.875 12.4 12 4 abnormal hepatic vein morphology 0.0516829510082659 0.15479992851663 0.769059817225145 0.875 12.4 12 4 anomalous pulmonary venous connection 0.0516829510082659 0.15479992851663 0.769059817225145 0.875 12.4 12 4 increased heart right ventricle size 0.0516829510082659 0.15479992851663 0.769059817225145 0.875 12.4 12 4 impaired mucociliary clearance 0.0516829510082659 0.15479992851663 0.769059817225145 0.875 12.4 12 4 abnormal anterior commissure pars posterior morphology 0.0516829510082659 0.15479992851663 0.769059817225145 0.875 12.4 12 4 decreased alveolar lamellar body number 0.0516829510082659 0.15479992851663 0.769059817225145 0.875 12.4 12 4 abnormal bronchiole epithelium morphology 0.0516829510082659 0.15479992851663 0.769059817225145 0.875 12.4 12 4 abnormal foramen magnum morphology 0.0516829510082659 0.15479992851663 0.769059817225145 0.875 12.4 12 4 increased circulating ferritin level 0.0516829510082659 0.15479992851663 0.769059817225145 0.875 12.4 12 4 abnormal heart echocardiography feature 0.0516829510082659 0.15479992851663 0.769059817225145 0.875 12.4 12 4 prolonged PQ interval 0.0516829510082659 0.15479992851663 0.769059817225145 0.875 12.4 12 4 increased cornea thickness 0.0516829510082659 0.15479992851663 0.769059817225145 0.875 12.4 12 4 absent hypoglossal canal 0.0516829510082659 0.15479992851663 0.769059817225145 0.875 12.4 12 4 embryo cyst 0.0516829510082659 0.15479992851663 0.769059817225145 0.875 12.4 12 4 increased brain apoptosis 0.0516829510082659 0.15479992851663 0.769059817225145 0.875 12.4 12 4 decreased basal metabolism 0.0516829510082659 0.15479992851663 0.769059817225145 0.875 12.4 12 4 abnormal response to infection 1.03752791603965e-10 3.48763606911977e-09 0.767669112311538 0.873417721518987 12.4 12 4 increased circulating free fatty acid level 9.55388883971784e-10 2.67025825716833e-08 0.767512413166342 0.873239436619718 12.4 12 4 increased circulating aspartate transaminase level 8.84148949045871e-09 2.06508968145691e-07 0.767315917412844 0.873015873015873 12.4 12 4 abnormal cell nucleus morphology 7.73850450587927e-07 1.23000191427314e-05 0.766722249391634 0.872340425531915 12.4 12 4 decreased bone trabecula number 7.73850450587927e-07 1.23000191427314e-05 0.766722249391634 0.872340425531915 12.4 12 4 abnormal leukocyte adhesion 7.35981741114674e-06 9.34058459705485e-05 0.766242748297581 0.871794871794872 12.4 12 4 increased autoantibody level 7.35981741114674e-06 9.34058459705485e-05 0.766242748297581 0.871794871794872 12.4 12 4 failure of heart looping 7.35981741114674e-06 9.34058459705485e-05 0.766242748297581 0.871794871794872 12.4 12 4 autoimmune response 7.12411429981134e-05 0.000699062497861171 0.765515762767887 0.870967741935484 12.4 12 4 abnormal capillary morphology 7.12411429981134e-05 0.000699062497861171 0.765515762767887 0.870967741935484 12.4 12 4 abnormal maxilla morphology 1.35695002889728e-07 2.49466066929179e-06 0.764990717663108 0.87037037037037 12.4 12 4 decreased T cell number 5.89184679064387e-20 6.9790328055841e-18 0.764283048174058 0.869565217391304 12.4 12 4 thymus hypoplasia 2.65255195886991e-17 2.39935381734142e-15 0.764283048174058 0.869565217391304 12.4 12 4 increased lymphocyte cell number 2.58890195061252e-09 6.4722548765313e-08 0.764283048174058 0.869565217391304 12.4 12 4 conjunctivitis 0.000708950303804834 0.00505304836880953 0.764283048174058 0.869565217391304 12.4 12 4 abnormal sacral vertebrae morphology 0.000708950303804834 0.00505304836880953 0.764283048174058 0.869565217391304 12.4 12 4 abnormal ulna morphology 0.000708950303804834 0.00505304836880953 0.764283048174058 0.869565217391304 12.4 12 4 increased susceptibility to fungal infection 0.000708950303804834 0.00505304836880953 0.764283048174058 0.869565217391304 12.4 12 4 abnormal vertebral artery topology 0.000708950303804834 0.00505304836880953 0.764283048174058 0.869565217391304 12.4 12 4 abnormal NK cell physiology 2.39501330590432e-08 5.13585827451466e-07 0.763656586659161 0.868852459016393 12.4 12 4 increased mean corpuscular hemoglobin 9.92625741493476e-13 4.74837794608658e-11 0.763511045095094 0.868686868686869 12.4 12 4 lethality throughout fetal growth and development, complete penetrance 3.91448944771996e-23 7.49022500092569e-21 0.763277412584355 0.868421052631579 12.4 12 4 incomplete somite formation 1.21270265773119e-05 0.000144680952571047 0.763277412584355 0.868421052631579 12.4 12 4 decreased embryo size 3.98323730351477e-56 2.830943654998e-53 0.763083859290939 0.868200836820084 12.4 12 4 increased circulating bilirubin level 2.23006271849261e-07 3.95450864120821e-06 0.762841004686937 0.867924528301887 12.4 12 4 abnormal spleen morphology 3.1886868210633e-21 4.53249055279712e-19 0.762745697215087 0.867816091954023 12.4 12 4 pericardial edema 4.24869224229105e-09 1.02112289398058e-07 0.762597129685438 0.867647058823529 12.4 12 4 preweaning lethality, complete penetrance 3.71876014911242e-86 9.25041587091714e-83 0.762527262793117 0.867567567567568 12.4 12 4 increased metastatic potential 0.000117399836787514 0.00106971463006938 0.761735438013477 0.866666666666667 12.4 12 4 salivary gland inflammation 0.000117399836787514 0.00106971463006938 0.761735438013477 0.866666666666667 12.4 12 4 abnormal microglial cell physiology 0.000117399836787514 0.00106971463006938 0.761735438013477 0.866666666666667 12.4 12 4 abnormal brain vasculature morphology 0.000117399836787514 0.00106971463006938 0.761735438013477 0.866666666666667 12.4 12 4 interdigital webbing 0.00741023836627611 0.0350103854437071 0.761735438013477 0.866666666666667 12.4 12 4 decreased hepatocyte number 0.00741023836627611 0.0350103854437071 0.761735438013477 0.866666666666667 12.4 12 4 vagina atresia 0.00741023836627611 0.0350103854437071 0.761735438013477 0.866666666666667 12.4 12 4 abnormal placenta size 0.00741023836627611 0.0350103854437071 0.761735438013477 0.866666666666667 12.4 12 4 abnormal trophectoderm morphology 0.00741023836627611 0.0350103854437071 0.761735438013477 0.866666666666667 12.4 12 4 abnormal olfactory nerve morphology 0.00741023836627611 0.0350103854437071 0.761735438013477 0.866666666666667 12.4 12 4 abnormal energy homeostasis 0.00741023836627611 0.0350103854437071 0.761735438013477 0.866666666666667 12.4 12 4 abnormal dendritic cell morphology 0.00741023836627611 0.0350103854437071 0.761735438013477 0.866666666666667 12.4 12 4 decreased thymocyte apoptosis 0.00741023836627611 0.0350103854437071 0.761735438013477 0.866666666666667 12.4 12 4 absent chorion 0.00741023836627611 0.0350103854437071 0.761735438013477 0.866666666666667 12.4 12 4 bicuspid aortic valve 0.00741023836627611 0.0350103854437071 0.761735438013477 0.866666666666667 12.4 12 4 distended pericardium 3.65523237877258e-07 6.27061416703226e-06 0.760608610442452 0.865384615384615 12.4 12 4 abnormal female meiosis 3.65523237877258e-07 6.27061416703226e-06 0.760608610442452 0.865384615384615 12.4 12 4 embryonic lethality, complete penetrance 3.96770987586154e-37 2.19326184804568e-34 0.760449653575065 0.865203761755486 12.4 12 4 abnormal intestine morphology 1.23771839302703e-09 3.38332362929092e-08 0.760151788454198 0.864864864864865 12.4 12 4 abnormal calcium ion homeostasis 1.99107567868896e-05 0.000227192694988018 0.760151788454198 0.864864864864865 12.4 12 4 embryonic growth arrest 6.13469219182253e-27 1.60632071864827e-24 0.759944323446432 0.864628820960699 12.4 12 4 abnormal neural tube morphology 2.05598588521908e-19 2.37872785557324e-17 0.759565251580391 0.864197530864197 12.4 12 4 abnormal craniofacial morphology 7.82413329376098e-13 3.81618266043734e-11 0.759459902724415 0.864077669902913 12.4 12 4 abnormal abdominal fat pad morphology 0.00116853952621696 0.00765939939779889 0.759072027391053 0.863636363636364 12.4 12 4 abnormal facial nerve morphology 0.00116853952621696 0.00765939939779889 0.759072027391053 0.863636363636364 12.4 12 4 increased skin papilloma incidence 0.00116853952621696 0.00765939939779889 0.759072027391053 0.863636363636364 12.4 12 4 cleft upper lip 0.00116853952621696 0.00765939939779889 0.759072027391053 0.863636363636364 12.4 12 4 abnormal occipital bone morphology 0.00116853952621696 0.00765939939779889 0.759072027391053 0.863636363636364 12.4 12 4 decreased susceptibility to viral infection induced morbidity/mortality 0.00116853952621696 0.00765939939779889 0.759072027391053 0.863636363636364 12.4 12 4 increased adenoma incidence 0.00116853952621696 0.00765939939779889 0.759072027391053 0.863636363636364 12.4 12 4 impaired humoral immune response 0.00116853952621696 0.00765939939779889 0.759072027391053 0.863636363636364 12.4 12 4 increased B cell number 2.54206830778547e-14 1.45365400358997e-12 0.758730564490742 0.863247863247863 12.4 12 4 increased inflammatory response 7.0961086302638e-12 3.01736243038995e-10 0.758651488871722 0.863157894736842 12.4 12 4 decreased bone marrow cell number 2.02033643955463e-09 5.1810174158682e-08 0.75852475123576 0.863013698630137 12.4 12 4 seminiferous tubule degeneration 2.02033643955463e-09 5.1810174158682e-08 0.75852475123576 0.863013698630137 12.4 12 4 pallor 1.10138951211387e-20 1.4049776468632e-18 0.758387150373858 0.862857142857143 12.4 12 4 small lung 5.97464893509193e-07 9.74553391871553e-06 0.758288671325633 0.862745098039216 12.4 12 4 abnormal trophoblast layer morphology 5.97464893509193e-07 9.74553391871553e-06 0.758288671325633 0.862745098039216 12.4 12 4 failure of chorioallantoic fusion 5.97464893509193e-07 9.74553391871553e-06 0.758288671325633 0.862745098039216 12.4 12 4 anemia 1.32317490038078e-24 2.99217960427018e-22 0.758125317454172 0.862559241706161 12.4 12 4 increased mortality induced by gamma-irradiation 0.000192602410183236 0.00165778026066021 0.75769440120704 0.862068965517241 12.4 12 4 increased double-positive T cell number 0.000192602410183236 0.00165778026066021 0.75769440120704 0.862068965517241 12.4 12 4 reduced long term depression 3.25673835361827e-05 0.000352990703905248 0.756852518539032 0.861111111111111 12.4 12 4 abnormal trophoblast giant cell morphology 3.25673835361827e-05 0.000352990703905248 0.756852518539032 0.861111111111111 12.4 12 4 abnormal placenta labyrinth morphology 5.86529085268931e-10 1.68669491283984e-08 0.756543473002675 0.860759493670886 12.4 12 4 abnormal nervous system morphology 5.86529085268931e-10 1.68669491283984e-08 0.756543473002675 0.860759493670886 12.4 12 4 embryonic lethality during organogenesis, complete penetrance 2.01326365261368e-62 2.00319733435062e-59 0.756503738576572 0.860714285714286 12.4 12 4 delayed endochondral bone ossification 5.59898704905964e-06 7.46781784693612e-05 0.756284737204794 0.86046511627907 12.4 12 4 lethality throughout fetal growth and development, incomplete penetrance 8.59837644714614e-21 1.12570849538295e-18 0.756170546545394 0.860335195530726 12.4 12 4 abnormal craniofacial bone morphology 1.70802288730373e-07 3.08996867794038e-06 0.755567539729967 0.859649122807018 12.4 12 4 abnormal facial morphology 1.70802288730373e-07 3.08996867794038e-06 0.755567539729967 0.859649122807018 12.4 12 4 increased urine protein level 9.5287663596789e-10 2.67025825716833e-08 0.754974472587322 0.858974358974359 12.4 12 4 increased grip strength 4.94364180544811e-11 1.75675842729317e-09 0.753364718914428 0.857142857142857 12.4 12 4 abnormal reproductive system morphology 9.10804197672848e-06 0.000113281272085561 0.753364718914428 0.857142857142857 12.4 12 4 abnormal stria vascularis morphology 0.000314470649807332 0.00253153961616744 0.753364718914428 0.857142857142857 12.4 12 4 rib bifurcation 0.000314470649807332 0.00253153961616744 0.753364718914428 0.857142857142857 12.4 12 4 enhanced coordination 0.000314470649807332 0.00253153961616744 0.753364718914428 0.857142857142857 12.4 12 4 increased triglyceride level 0.000314470649807332 0.00253153961616744 0.753364718914428 0.857142857142857 12.4 12 4 prolonged QRS complex duration 0.000314470649807332 0.00253153961616744 0.753364718914428 0.857142857142857 12.4 12 4 abnormal salivary gland morphology 0.00191457893648499 0.0116158904987961 0.753364718914428 0.857142857142857 12.4 12 4 liver degeneration 0.00191457893648499 0.0116158904987961 0.753364718914428 0.857142857142857 12.4 12 4 abnormal erythrocyte physiology 0.00191457893648499 0.0116158904987961 0.753364718914428 0.857142857142857 12.4 12 4 increased acute inflammation 0.00191457893648499 0.0116158904987961 0.753364718914428 0.857142857142857 12.4 12 4 abnormal stapes morphology 0.00191457893648499 0.0116158904987961 0.753364718914428 0.857142857142857 12.4 12 4 increased muscle cell glucose uptake 0.00191457893648499 0.0116158904987961 0.753364718914428 0.857142857142857 12.4 12 4 abnormal interparietal bone morphology 0.0122178409678905 0.0520408893966227 0.753364718914428 0.857142857142857 12.4 12 4 midline facial cleft 0.0122178409678905 0.0520408893966227 0.753364718914428 0.857142857142857 12.4 12 4 abnormal antigen presentation 0.0122178409678905 0.0520408893966227 0.753364718914428 0.857142857142857 12.4 12 4 failure of zygotic cell division 0.0122178409678905 0.0520408893966227 0.753364718914428 0.857142857142857 12.4 12 4 vascular smooth muscle hypoplasia 0.0122178409678905 0.0520408893966227 0.753364718914428 0.857142857142857 12.4 12 4 increased B-1 B cell number 0.0122178409678905 0.0520408893966227 0.753364718914428 0.857142857142857 12.4 12 4 premature hair loss 0.0122178409678905 0.0520408893966227 0.753364718914428 0.857142857142857 12.4 12 4 spina bifida occulta 0.0122178409678905 0.0520408893966227 0.753364718914428 0.857142857142857 12.4 12 4 increased pulmonary respiratory rate 0.0122178409678905 0.0520408893966227 0.753364718914428 0.857142857142857 12.4 12 4 sternebra fusion 0.0122178409678905 0.0520408893966227 0.753364718914428 0.857142857142857 12.4 12 4 increased stomach tumor incidence 0.0122178409678905 0.0520408893966227 0.753364718914428 0.857142857142857 12.4 12 4 pulmonary alveolar hemorrhage 0.0122178409678905 0.0520408893966227 0.753364718914428 0.857142857142857 12.4 12 4 decreased compact bone area 0.0122178409678905 0.0520408893966227 0.753364718914428 0.857142857142857 12.4 12 4 abnormal renal tubule epithelial cell primary cilium morphology 0.0122178409678905 0.0520408893966227 0.753364718914428 0.857142857142857 12.4 12 4 abnormal vitelline vein topology 0.0122178409678905 0.0520408893966227 0.753364718914428 0.857142857142857 12.4 12 4 asymmetric rib joints 0.0864923037522462 0.221006271786043 0.753364718914428 0.857142857142857 12.4 12 4 maxilla hypoplasia 0.0864923037522462 0.221006271786043 0.753364718914428 0.857142857142857 12.4 12 4 decreased Schwann cell number 0.0864923037522462 0.221006271786043 0.753364718914428 0.857142857142857 12.4 12 4 skin photosensitivity 0.0864923037522462 0.221006271786043 0.753364718914428 0.857142857142857 12.4 12 4 absent epidermis stratum corneum 0.0864923037522462 0.221006271786043 0.753364718914428 0.857142857142857 12.4 12 4 abnormal lacrimal gland morphology 0.0864923037522462 0.221006271786043 0.753364718914428 0.857142857142857 12.4 12 4 absent amniotic folds 0.0864923037522462 0.221006271786043 0.753364718914428 0.857142857142857 12.4 12 4 abnormal tumor incidence 0.0864923037522462 0.221006271786043 0.753364718914428 0.857142857142857 12.4 12 4 increased colonic adenoma incidence 0.0864923037522462 0.221006271786043 0.753364718914428 0.857142857142857 12.4 12 4 abnormal gastrulation movements 0.0864923037522462 0.221006271786043 0.753364718914428 0.857142857142857 12.4 12 4 abnormal brain ventricular system morphology 0.0864923037522462 0.221006271786043 0.753364718914428 0.857142857142857 12.4 12 4 abnormal lymph node primary follicle morphology 0.0864923037522462 0.221006271786043 0.753364718914428 0.857142857142857 12.4 12 4 abnormal melanocyte morphology 0.0864923037522462 0.221006271786043 0.753364718914428 0.857142857142857 12.4 12 4 decreased mortality induced by ionizing radiation 0.0864923037522462 0.221006271786043 0.753364718914428 0.857142857142857 12.4 12 4 calcinosis 0.0864923037522462 0.221006271786043 0.753364718914428 0.857142857142857 12.4 12 4 decreased cardiomyocyte apoptosis 0.0864923037522462 0.221006271786043 0.753364718914428 0.857142857142857 12.4 12 4 aorta coarctation 0.0864923037522462 0.221006271786043 0.753364718914428 0.857142857142857 12.4 12 4 skeletal muscle interstitial fibrosis 0.0864923037522462 0.221006271786043 0.753364718914428 0.857142857142857 12.4 12 4 abnormal nephron morphology 0.0864923037522462 0.221006271786043 0.753364718914428 0.857142857142857 12.4 12 4 increased ectoderm apoptosis 0.0864923037522462 0.221006271786043 0.753364718914428 0.857142857142857 12.4 12 4 abnormal optic tract morphology 0.0864923037522462 0.221006271786043 0.753364718914428 0.857142857142857 12.4 12 4 utricular macular degeneration 0.0864923037522462 0.221006271786043 0.753364718914428 0.857142857142857 12.4 12 4 abnormal cochlear nerve compound action potential 0.0864923037522462 0.221006271786043 0.753364718914428 0.857142857142857 12.4 12 4 abnormal ciliary body morphology 0.0864923037522462 0.221006271786043 0.753364718914428 0.857142857142857 12.4 12 4 abnormal talus morphology 0.0864923037522462 0.221006271786043 0.753364718914428 0.857142857142857 12.4 12 4 absent thyroid gland 0.0864923037522462 0.221006271786043 0.753364718914428 0.857142857142857 12.4 12 4 atherosclerotic lesions 0.0864923037522462 0.221006271786043 0.753364718914428 0.857142857142857 12.4 12 4 urolithiasis 0.0864923037522462 0.221006271786043 0.753364718914428 0.857142857142857 12.4 12 4 retinal pigment epithelium atrophy 0.0864923037522462 0.221006271786043 0.753364718914428 0.857142857142857 12.4 12 4 absent popliteal lymph nodes 0.0864923037522462 0.221006271786043 0.753364718914428 0.857142857142857 12.4 12 4 uremia 0.0864923037522462 0.221006271786043 0.753364718914428 0.857142857142857 12.4 12 4 abnormal uterus physiology 0.0864923037522462 0.221006271786043 0.753364718914428 0.857142857142857 12.4 12 4 abnormal spinal cord central canal morphology 0.0864923037522462 0.221006271786043 0.753364718914428 0.857142857142857 12.4 12 4 postaxial polydactyly 0.0864923037522462 0.221006271786043 0.753364718914428 0.857142857142857 12.4 12 4 increased tumor latency 0.0864923037522462 0.221006271786043 0.753364718914428 0.857142857142857 12.4 12 4 abnormal sperm annulus morphology 0.0864923037522462 0.221006271786043 0.753364718914428 0.857142857142857 12.4 12 4 arteritis 0.0864923037522462 0.221006271786043 0.753364718914428 0.857142857142857 12.4 12 4 increased oligodendrocyte number 0.0864923037522462 0.221006271786043 0.753364718914428 0.857142857142857 12.4 12 4 decreased T-helper 17 cell number 0.0864923037522462 0.221006271786043 0.753364718914428 0.857142857142857 12.4 12 4 decreased skeletal muscle glycogen level 0.0864923037522462 0.221006271786043 0.753364718914428 0.857142857142857 12.4 12 4 heart block 0.0864923037522462 0.221006271786043 0.753364718914428 0.857142857142857 12.4 12 4 abnormal conotruncal ridge morphology 0.0864923037522462 0.221006271786043 0.753364718914428 0.857142857142857 12.4 12 4 thick mitral valve cusps 0.0864923037522462 0.221006271786043 0.753364718914428 0.857142857142857 12.4 12 4 abnormal impulsive behavior control 0.0864923037522462 0.221006271786043 0.753364718914428 0.857142857142857 12.4 12 4 increased right ventricle systolic pressure 0.0864923037522462 0.221006271786043 0.753364718914428 0.857142857142857 12.4 12 4 dilated pulmonary alveolar ducts 0.0864923037522462 0.221006271786043 0.753364718914428 0.857142857142857 12.4 12 4 increased compact bone volume 0.0864923037522462 0.221006271786043 0.753364718914428 0.857142857142857 12.4 12 4 abnormal brain ependyma motile cilium physiology 0.0864923037522462 0.221006271786043 0.753364718914428 0.857142857142857 12.4 12 4 embryonic lethality at implantation, incomplete penetrance 0.0864923037522462 0.221006271786043 0.753364718914428 0.857142857142857 12.4 12 4 small tail bud 0.0864923037522462 0.221006271786043 0.753364718914428 0.857142857142857 12.4 12 4 impaired mammary gland growth during pregnancy 0.0864923037522462 0.221006271786043 0.753364718914428 0.857142857142857 12.4 12 4 absent heart tube 0.0864923037522462 0.221006271786043 0.753364718914428 0.857142857142857 12.4 12 4 decreased areal bone mineral density 0.0864923037522462 0.221006271786043 0.753364718914428 0.857142857142857 12.4 12 4 embryo tumor 0.0864923037522462 0.221006271786043 0.753364718914428 0.857142857142857 12.4 12 4 increased abdominal adipose tissue amount 0.0864923037522462 0.221006271786043 0.753364718914428 0.857142857142857 12.4 12 4 oxidative stress 7.99713086832361e-11 2.72504973081575e-09 0.751969599064587 0.855555555555556 12.4 12 4 abnormal neural tube closure 4.46506580827697e-10 1.32224419024869e-08 0.751851938354359 0.855421686746988 12.4 12 4 abnormal axial skeleton morphology 2.49975567810284e-09 6.31283477084348e-08 0.751712603302774 0.855263157894737 12.4 12 4 abnormal blood vessel morphology 1.44575619286313e-16 1.17912082942526e-14 0.751632845997384 0.855172413793103 12.4 12 4 thrombocytopenia 1.44575619286313e-16 1.17912082942526e-14 0.751632845997384 0.855172413793103 12.4 12 4 perimembraneous ventricular septal defect 1.40414549631941e-08 3.13256674627312e-07 0.751544997371157 0.855072463768116 12.4 12 4 increased tumor incidence 2.44515631880069e-14 1.41449449837598e-12 0.751339544938852 0.854838709677419 12.4 12 4 abnormal embryo turning 4.49058549927595e-07 7.57310605386368e-06 0.751081795523778 0.854545454545454 12.4 12 4 abnormal lymph node morphology 2.56334762247755e-06 3.63323487801306e-05 0.750748869195975 0.854166666666667 12.4 12 4 decreased rib number 1.29133631821998e-10 4.28293212209625e-09 0.750543128206884 0.853932584269663 12.4 12 4 abnormal mammary gland development 1.47633677604262e-05 0.000172818246136754 0.750302260707459 0.853658536585366 12.4 12 4 Leydig cell hyperplasia 1.47633677604262e-05 0.000172818246136754 0.750302260707459 0.853658536585366 12.4 12 4 abnormal cell differentiation 1.47633677604262e-05 0.000172818246136754 0.750302260707459 0.853658536585366 12.4 12 4 abnormal limb morphology 4.03611755535078e-09 9.79496821359519e-08 0.750016431274809 0.853333333333333 12.4 12 4 kinked tail 6.72208509733697e-12 2.88296322062512e-10 0.749671754606024 0.852941176470588 12.4 12 4 abnormal extraembryonic tissue morphology 6.72208509733697e-12 2.88296322062512e-10 0.749671754606024 0.852941176470588 12.4 12 4 enlarged liver sinusoidal spaces 8.60763954113948e-05 0.000818795539525218 0.749671754606024 0.852941176470588 12.4 12 4 abnormal oocyte morphology 8.60763954113948e-05 0.000818795539525218 0.749671754606024 0.852941176470588 12.4 12 4 abnormal direction of heart looping 8.60763954113948e-05 0.000818795539525218 0.749671754606024 0.852941176470588 12.4 12 4 increased susceptibility to viral infection induced morbidity/mortality 8.60763954113948e-05 0.000818795539525218 0.749671754606024 0.852941176470588 12.4 12 4 increased osteoclast cell number 1.27872450655372e-07 2.38264210490814e-06 0.749247971816535 0.852459016393443 12.4 12 4 embryonic lethality during organogenesis, incomplete penetrance 5.79788311641751e-25 1.37354611924653e-22 0.748997387210576 0.852173913043478 12.4 12 4 abnormal chondrocyte morphology 7.25046068366576e-07 1.16940494263439e-05 0.748714319414956 0.851851851851852 12.4 12 4 thin epidermis 0.000510828514411452 0.00385640646312136 0.748714319414956 0.851851851851852 12.4 12 4 increased brain weight 0.000510828514411452 0.00385640646312136 0.748714319414956 0.851851851851852 12.4 12 4 abnormal skin appearance 0.000510828514411452 0.00385640646312136 0.748714319414956 0.851851851851852 12.4 12 4 decreased circulating fructosamine level 0.000510828514411452 0.00385640646312136 0.748714319414956 0.851851851851852 12.4 12 4 abnormal bone trabecula morphology 0.000510828514411452 0.00385640646312136 0.748714319414956 0.851851851851852 12.4 12 4 increased respiratory quotient 4.13897927057708e-06 5.59549507367418e-05 0.748021706723546 0.851063829787234 12.4 12 4 rib fusion 3.65164488541067e-08 7.6012273242335e-07 0.74774259414641 0.850746268656716 12.4 12 4 abnormal embryonic tissue morphology 2.83586070123702e-16 2.20443859197721e-14 0.747385633843679 0.850340136054422 12.4 12 4 abnormal posture 1.86835042671733e-09 4.91801236662367e-08 0.747086679590141 0.85 12.4 12 4 abnormal cell proliferation 0.00311646895246634 0.0174011594147251 0.747086679590141 0.85 12.4 12 4 abnormal circulating enzyme level 0.00311646895246634 0.0174011594147251 0.747086679590141 0.85 12.4 12 4 brain inflammation 0.00311646895246634 0.0174011594147251 0.747086679590141 0.85 12.4 12 4 decreased myocardial infarction size 0.00311646895246634 0.0174011594147251 0.747086679590141 0.85 12.4 12 4 abnormal hyoid bone morphology 0.00311646895246634 0.0174011594147251 0.747086679590141 0.85 12.4 12 4 dilated vasculature 0.00311646895246634 0.0174011594147251 0.747086679590141 0.85 12.4 12 4 abnormal incus morphology 0.00311646895246634 0.0174011594147251 0.747086679590141 0.85 12.4 12 4 abnormal sperm mitochondrial sheath morphology 0.00311646895246634 0.0174011594147251 0.747086679590141 0.85 12.4 12 4 intracranial hemorrhage 2.05912315902113e-07 3.67173394843374e-06 0.747086679590141 0.85 12.4 12 4 abnormal long bone epiphyseal plate morphology 2.05912315902113e-07 3.67173394843374e-06 0.747086679590141 0.85 12.4 12 4 increased erythrocyte cell number 2.05912315902113e-07 3.67173394843374e-06 0.747086679590141 0.85 12.4 12 4 abnormal locomotor coordination 0.000139021720498186 0.00125980520852181 0.745754974278929 0.848484848484849 12.4 12 4 diarrhea 0.000139021720498186 0.00125980520852181 0.745754974278929 0.848484848484849 12.4 12 4 abnormal somite development 2.99831712737039e-09 7.31207240620966e-08 0.745417833693812 0.848101265822785 12.4 12 4 abnormal immune system morphology 6.66050497551397e-06 8.62916985759948e-05 0.745175971969706 0.847826086956522 12.4 12 4 abnormal allantois morphology 6.66050497551397e-06 8.62916985759948e-05 0.745175971969706 0.847826086956522 12.4 12 4 abnormal humoral immune response 8.06351543509958e-12 3.37109153694289e-10 0.744993999815379 0.847619047619048 12.4 12 4 abnormal lung development 8.6152158399828e-10 2.43526697749514e-08 0.744501604574258 0.847058823529412 12.4 12 4 polydactyly 4.46808359143298e-11 1.62253400491818e-09 0.744396091308304 0.846938775510204 12.4 12 4 decreased leukocyte cell number 6.43477393696566e-15 3.9522222637536e-13 0.74419969800306 0.846715328467153 12.4 12 4 liver hypoplasia 1.87314399948485e-06 2.73281272652115e-05 0.743706196877064 0.846153846153846 12.4 12 4 eyelids open at birth 1.87314399948485e-06 2.73281272652115e-05 0.743706196877064 0.846153846153846 12.4 12 4 abnormal xiphoid process morphology 0.000825245249038245 0.00576628527242313 0.743706196877064 0.846153846153846 12.4 12 4 abnormal leukocyte cell number 0.000825245249038245 0.00576628527242313 0.743706196877064 0.846153846153846 12.4 12 4 ventricular hypoplasia 0.000825245249038245 0.00576628527242313 0.743706196877064 0.846153846153846 12.4 12 4 abnormal ureter morphology 0.000825245249038245 0.00576628527242313 0.743706196877064 0.846153846153846 12.4 12 4 increased susceptibility to otitis media 0.000825245249038245 0.00576628527242313 0.743706196877064 0.846153846153846 12.4 12 4 pulmonary edema 0.000825245249038245 0.00576628527242313 0.743706196877064 0.846153846153846 12.4 12 4 abnormal membranous labyrinth morphology 0.0199620442275769 0.0777257372211341 0.743706196877064 0.846153846153846 12.4 12 4 short premaxilla 0.0199620442275769 0.0777257372211341 0.743706196877064 0.846153846153846 12.4 12 4 abnormal renal/urinary system morphology 0.0199620442275769 0.0777257372211341 0.743706196877064 0.846153846153846 12.4 12 4 increased pituitary adenoma incidence 0.0199620442275769 0.0777257372211341 0.743706196877064 0.846153846153846 12.4 12 4 lymphoid hypoplasia 0.0199620442275769 0.0777257372211341 0.743706196877064 0.846153846153846 12.4 12 4 abnormal pulmonary alveolus epithelial cell morphology 0.0199620442275769 0.0777257372211341 0.743706196877064 0.846153846153846 12.4 12 4 abnormal soleus morphology 0.0199620442275769 0.0777257372211341 0.743706196877064 0.846153846153846 12.4 12 4 axonal dystrophy 0.0199620442275769 0.0777257372211341 0.743706196877064 0.846153846153846 12.4 12 4 small otic vesicle 0.0199620442275769 0.0777257372211341 0.743706196877064 0.846153846153846 12.4 12 4 small interparietal bone 0.0199620442275769 0.0777257372211341 0.743706196877064 0.846153846153846 12.4 12 4 increased cochlear inner hair cell number 0.0199620442275769 0.0777257372211341 0.743706196877064 0.846153846153846 12.4 12 4 decreased endocochlear potential 0.0199620442275769 0.0777257372211341 0.743706196877064 0.846153846153846 12.4 12 4 small pituitary gland 0.0199620442275769 0.0777257372211341 0.743706196877064 0.846153846153846 12.4 12 4 empty decidua capsularis 0.0199620442275769 0.0777257372211341 0.743706196877064 0.846153846153846 12.4 12 4 abnormal spermiogenesis 5.29526922300956e-07 8.75214763603739e-06 0.742540513182899 0.844827586206897 12.4 12 4 abnormal embryonic neuroepithelium morphology 5.29526922300956e-07 8.75214763603739e-06 0.742540513182899 0.844827586206897 12.4 12 4 abnormal ectoderm development 1.06803143650063e-05 0.000130551754215987 0.742203760115696 0.844444444444444 12.4 12 4 albuminuria 1.06803143650063e-05 0.000130551754215987 0.742203760115696 0.844444444444444 12.4 12 4 abnormal cytokine secretion 2.51231972987483e-16 1.98393502478211e-14 0.741950101961179 0.844155844155844 12.4 12 4 abnormal vertebrae morphology 5.9488783952022e-12 2.59611140492377e-10 0.741845380704727 0.844036697247706 12.4 12 4 increased bone mineral content 5.9488783952022e-12 2.59611140492377e-10 0.741845380704727 0.844036697247706 12.4 12 4 decreased susceptibility to parasitic infection 0.000223473449375253 0.00189400410671531 0.74159339518139 0.84375 12.4 12 4 increased lung adenocarcinoma incidence 2.99648101369092e-06 4.18749804581807e-05 0.741054837886415 0.843137254901961 12.4 12 4 absent vitelline blood vessels 8.45480312006594e-07 1.319599739946e-05 0.740147794021193 0.842105263157895 12.4 12 4 decreased brain weight 8.45480312006594e-07 1.319599739946e-05 0.740147794021193 0.842105263157895 12.4 12 4 decreased susceptibility to induced arthritis 8.45480312006594e-07 1.319599739946e-05 0.740147794021193 0.842105263157895 12.4 12 4 impaired natural killer cell mediated cytotoxicity 8.45480312006594e-07 1.319599739946e-05 0.740147794021193 0.842105263157895 12.4 12 4 increased bone marrow cell number 6.14239845713038e-05 0.000616097425891605 0.740147794021193 0.842105263157895 12.4 12 4 kyphoscoliosis 0.00503656137646753 0.0260737698729719 0.740147794021193 0.842105263157895 12.4 12 4 altered susceptibility to infection 0.00503656137646753 0.0260737698729719 0.740147794021193 0.842105263157895 12.4 12 4 increased malignant tumor incidence 0.00503656137646753 0.0260737698729719 0.740147794021193 0.842105263157895 12.4 12 4 abnormal nasal septum morphology 0.00503656137646753 0.0260737698729719 0.740147794021193 0.842105263157895 12.4 12 4 increased liver adenoma incidence 0.00503656137646753 0.0260737698729719 0.740147794021193 0.842105263157895 12.4 12 4 abnormal optic vesicle formation 0.00503656137646753 0.0260737698729719 0.740147794021193 0.842105263157895 12.4 12 4 absent amnion 0.00503656137646753 0.0260737698729719 0.740147794021193 0.842105263157895 12.4 12 4 double outlet right ventricle 1.50744532618643e-11 5.99963239822201e-10 0.739283135383317 0.841121495327103 12.4 12 4 abnormal astrocyte morphology 1.70629572130857e-05 0.000196956408666128 0.739096447722867 0.840909090909091 12.4 12 4 muscular atrophy 1.70629572130857e-05 0.000196956408666128 0.739096447722867 0.840909090909091 12.4 12 4 abnormal amino acid level 1.70629572130857e-05 0.000196956408666128 0.739096447722867 0.840909090909091 12.4 12 4 microcephaly 6.81713667937788e-08 1.36205843292791e-06 0.738806946568256 0.840579710144927 12.4 12 4 perinatal lethality, complete penetrance 1.6991317365563e-21 2.56156981495988e-19 0.738627537402018 0.84037558685446 12.4 12 4 abnormal liver physiology 8.30710133855725e-11 2.81141694961376e-09 0.73829742453614 0.84 12.4 12 4 increased body length 4.77753039886776e-06 6.40652661303695e-05 0.73829742453614 0.84 12.4 12 4 ruffled hair 0.001325322381865 0.00859645221613868 0.73829742453614 0.84 12.4 12 4 mandible hypoplasia 0.001325322381865 0.00859645221613868 0.73829742453614 0.84 12.4 12 4 abnormal primitive streak morphology 0.001325322381865 0.00859645221613868 0.73829742453614 0.84 12.4 12 4 diaphragmatic hernia 0.001325322381865 0.00859645221613868 0.73829742453614 0.84 12.4 12 4 decreased body length 4.52263037167945e-27 1.32353447641796e-24 0.737784183365103 0.839416058394161 12.4 12 4 abnormal immune system physiology 5.75895191420743e-13 2.83671146269128e-11 0.737163327109817 0.838709677419355 12.4 12 4 pericardial effusion 3.80971153570183e-07 6.51316662890606e-06 0.737163327109817 0.838709677419355 12.4 12 4 absent mature ovarian follicles 0.000357425044492396 0.00280471545165563 0.737163327109817 0.838709677419355 12.4 12 4 decreased thymus weight 0.000357425044492396 0.00280471545165563 0.737163327109817 0.838709677419355 12.4 12 4 preaxial polydactyly 0.000357425044492396 0.00280471545165563 0.737163327109817 0.838709677419355 12.4 12 4 abnormal mitochondrial ATP synthesis coupled electron transport 0.000357425044492396 0.00280471545165563 0.737163327109817 0.838709677419355 12.4 12 4 abnormal brain morphology 2.14113868965723e-16 1.71809112597495e-14 0.736987225024984 0.838509316770186 12.4 12 4 decreased circulating serum albumin level 1.31738207392258e-10 4.34038133626812e-09 0.736876938870846 0.838383838383838 12.4 12 4 decreased susceptibility to injury 1.08261766713372e-07 2.06361030421084e-06 0.73674637952661 0.838235294117647 12.4 12 4 increased circulating HDL cholesterol level 3.79389451774215e-11 1.38784009012994e-09 0.73662328071633 0.838095238095238 12.4 12 4 abnormal angiogenesis 3.0863486642647e-08 6.45150613643567e-07 0.736397045065004 0.837837837837838 12.4 12 4 increased circulating creatinine level 2.52728752935587e-09 6.3501290194674e-08 0.735844609172232 0.837209302325581 12.4 12 4 increased sarcoma incidence 7.59080141994708e-06 9.56056634537638e-05 0.73542746370218 0.836734693877551 12.4 12 4 abnormal craniofacial development 7.59080141994708e-06 9.56056634537638e-05 0.73542746370218 0.836734693877551 12.4 12 4 decreased circulating creatinine level 7.59080141994708e-06 9.56056634537638e-05 0.73542746370218 0.836734693877551 12.4 12 4 decreased hematocrit 1.00868047889931e-14 5.97403021729056e-13 0.734444600402879 0.835616438356164 12.4 12 4 abnormal heart development 8.46204472915135e-16 6.14943349382905e-14 0.734292194384949 0.835443037974684 12.4 12 4 abnormal nervous system physiology 7.8794639355694e-12 3.32206212537777e-10 0.733711726247095 0.834782608695652 12.4 12 4 kyphosis 7.25791630964008e-15 4.40343093176334e-13 0.732437921166805 0.833333333333333 12.4 12 4 impaired limb coordination 3.37785668887558e-06 4.62943168792177e-05 0.732437921166805 0.833333333333333 12.4 12 4 abnormal long bone epiphyseal plate proliferative zone 3.37785668887558e-06 4.62943168792177e-05 0.732437921166805 0.833333333333333 12.4 12 4 axon degeneration 3.37785668887558e-06 4.62943168792177e-05 0.732437921166805 0.833333333333333 12.4 12 4 abnormal intestinal epithelium morphology 1.20171375110747e-05 0.00014371456518653 0.732437921166805 0.833333333333333 12.4 12 4 thymus atrophy 1.20171375110747e-05 0.00014371456518653 0.732437921166805 0.833333333333333 12.4 12 4 abnormal osteoclast morphology 1.20171375110747e-05 0.00014371456518653 0.732437921166805 0.833333333333333 12.4 12 4 abnormal vasodilation 0.0021148858068488 0.0125107691903362 0.732437921166805 0.833333333333333 12.4 12 4 blindness 0.0021148858068488 0.0125107691903362 0.732437921166805 0.833333333333333 12.4 12 4 abnormal sensory capabilities/reflexes/nociception 0.0021148858068488 0.0125107691903362 0.732437921166805 0.833333333333333 12.4 12 4 small lymph nodes 0.0021148858068488 0.0125107691903362 0.732437921166805 0.833333333333333 12.4 12 4 decreased fatty acid level 0.0021148858068488 0.0125107691903362 0.732437921166805 0.833333333333333 12.4 12 4 hypopigmentation 0.0021148858068488 0.0125107691903362 0.732437921166805 0.833333333333333 12.4 12 4 increased body temperature 0.0021148858068488 0.0125107691903362 0.732437921166805 0.833333333333333 12.4 12 4 absent optic nerve 0.0322763458416251 0.109086155273155 0.732437921166805 0.833333333333333 12.4 12 4 abnormal mating frequency 0.0322763458416251 0.109086155273155 0.732437921166805 0.833333333333333 12.4 12 4 impaired embryo implantation 0.0322763458416251 0.109086155273155 0.732437921166805 0.833333333333333 12.4 12 4 abnormal thymus involution 0.0322763458416251 0.109086155273155 0.732437921166805 0.833333333333333 12.4 12 4 myocarditis 0.0322763458416251 0.109086155273155 0.732437921166805 0.833333333333333 12.4 12 4 interstitial pneumonia 0.0322763458416251 0.109086155273155 0.732437921166805 0.833333333333333 12.4 12 4 increased papilloma incidence 0.0322763458416251 0.109086155273155 0.732437921166805 0.833333333333333 12.4 12 4 abnormal embryonic growth/weight/body size 0.0322763458416251 0.109086155273155 0.732437921166805 0.833333333333333 12.4 12 4 altered tumor susceptibility 0.0322763458416251 0.109086155273155 0.732437921166805 0.833333333333333 12.4 12 4 abnormal vascular endothelial cell development 0.0322763458416251 0.109086155273155 0.732437921166805 0.833333333333333 12.4 12 4 abnormal nucleotide metabolism 0.0322763458416251 0.109086155273155 0.732437921166805 0.833333333333333 12.4 12 4 abnormal defecation 0.0322763458416251 0.109086155273155 0.732437921166805 0.833333333333333 12.4 12 4 increased hepatocyte proliferation 0.0322763458416251 0.109086155273155 0.732437921166805 0.833333333333333 12.4 12 4 abnormal cochlear outer hair cell physiology 0.0322763458416251 0.109086155273155 0.732437921166805 0.833333333333333 12.4 12 4 decreased keratinocyte proliferation 0.0322763458416251 0.109086155273155 0.732437921166805 0.833333333333333 12.4 12 4 abnormal aorta elastic tissue morphology 0.0322763458416251 0.109086155273155 0.732437921166805 0.833333333333333 12.4 12 4 decreased mammary gland epithelial cell proliferation 0.0322763458416251 0.109086155273155 0.732437921166805 0.833333333333333 12.4 12 4 abnormal ear shape 0.142556988375163 0.324371591506224 0.732437921166805 0.833333333333333 12.4 12 4 large anterior fontanelle 0.142556988375163 0.324371591506224 0.732437921166805 0.833333333333333 12.4 12 4 arrest of tooth development 0.142556988375163 0.324371591506224 0.732437921166805 0.833333333333333 12.4 12 4 hemoglobinuria 0.142556988375163 0.324371591506224 0.732437921166805 0.833333333333333 12.4 12 4 abnormal urethra morphology 0.142556988375163 0.324371591506224 0.732437921166805 0.833333333333333 12.4 12 4 absent limbs 0.142556988375163 0.324371591506224 0.732437921166805 0.833333333333333 12.4 12 4 absent superior cervical ganglion 0.142556988375163 0.324371591506224 0.732437921166805 0.833333333333333 12.4 12 4 abnormal lens induction 0.142556988375163 0.324371591506224 0.732437921166805 0.833333333333333 12.4 12 4 jumpy 0.142556988375163 0.324371591506224 0.732437921166805 0.833333333333333 12.4 12 4 increased embryo size 0.142556988375163 0.324371591506224 0.732437921166805 0.833333333333333 12.4 12 4 abnormal parental behavior 0.142556988375163 0.324371591506224 0.732437921166805 0.833333333333333 12.4 12 4 abnormal lymph organ size 0.142556988375163 0.324371591506224 0.732437921166805 0.833333333333333 12.4 12 4 chromatolysis 0.142556988375163 0.324371591506224 0.732437921166805 0.833333333333333 12.4 12 4 increased post-tetanic potentiation 0.142556988375163 0.324371591506224 0.732437921166805 0.833333333333333 12.4 12 4 liver cirrhosis 0.142556988375163 0.324371591506224 0.732437921166805 0.833333333333333 12.4 12 4 delayed tooth eruption 0.142556988375163 0.324371591506224 0.732437921166805 0.833333333333333 12.4 12 4 absent cochlea 0.142556988375163 0.324371591506224 0.732437921166805 0.833333333333333 12.4 12 4 decreased posterior semicircular canal size 0.142556988375163 0.324371591506224 0.732437921166805 0.833333333333333 12.4 12 4 phenotypic reversion 0.142556988375163 0.324371591506224 0.732437921166805 0.833333333333333 12.4 12 4 calcified joint 0.142556988375163 0.324371591506224 0.732437921166805 0.833333333333333 12.4 12 4 extremity edema 0.142556988375163 0.324371591506224 0.732437921166805 0.833333333333333 12.4 12 4 decreased liver function 0.142556988375163 0.324371591506224 0.732437921166805 0.833333333333333 12.4 12 4 increased glycerol level 0.142556988375163 0.324371591506224 0.732437921166805 0.833333333333333 12.4 12 4 enlarged pancreas 0.142556988375163 0.324371591506224 0.732437921166805 0.833333333333333 12.4 12 4 short perineum 0.142556988375163 0.324371591506224 0.732437921166805 0.833333333333333 12.4 12 4 abnormal zona pellucida morphology 0.142556988375163 0.324371591506224 0.732437921166805 0.833333333333333 12.4 12 4 abnormal lambdoidal suture morphology 0.142556988375163 0.324371591506224 0.732437921166805 0.833333333333333 12.4 12 4 matted coat 0.142556988375163 0.324371591506224 0.732437921166805 0.833333333333333 12.4 12 4 shortened QT interval 0.142556988375163 0.324371591506224 0.732437921166805 0.833333333333333 12.4 12 4 abnormal cholesterol level 0.142556988375163 0.324371591506224 0.732437921166805 0.833333333333333 12.4 12 4 abnormal common crus morphology 0.142556988375163 0.324371591506224 0.732437921166805 0.833333333333333 12.4 12 4 decreased triiodothyronine level 0.142556988375163 0.324371591506224 0.732437921166805 0.833333333333333 12.4 12 4 increased triiodothyronine level 0.142556988375163 0.324371591506224 0.732437921166805 0.833333333333333 12.4 12 4 increased renal glomerular filtration rate 0.142556988375163 0.324371591506224 0.732437921166805 0.833333333333333 12.4 12 4 decreased platelet ADP level 0.142556988375163 0.324371591506224 0.732437921166805 0.833333333333333 12.4 12 4 absent brachial lymph nodes 0.142556988375163 0.324371591506224 0.732437921166805 0.833333333333333 12.4 12 4 delayed chorioallantoic fusion 0.142556988375163 0.324371591506224 0.732437921166805 0.833333333333333 12.4 12 4 increased urine uric acid level 0.142556988375163 0.324371591506224 0.732437921166805 0.833333333333333 12.4 12 4 absent sperm mitochondrial sheath 0.142556988375163 0.324371591506224 0.732437921166805 0.833333333333333 12.4 12 4 exostosis 0.142556988375163 0.324371591506224 0.732437921166805 0.833333333333333 12.4 12 4 abnormal olfactory bulb layer morphology 0.142556988375163 0.324371591506224 0.732437921166805 0.833333333333333 12.4 12 4 decreased DN1 thymic pro-T cell number 0.142556988375163 0.324371591506224 0.732437921166805 0.833333333333333 12.4 12 4 enlarged lymphatic vessel 0.142556988375163 0.324371591506224 0.732437921166805 0.833333333333333 12.4 12 4 abnormal epiglottis morphology 0.142556988375163 0.324371591506224 0.732437921166805 0.833333333333333 12.4 12 4 abnormal pharyngeal arch development 0.142556988375163 0.324371591506224 0.732437921166805 0.833333333333333 12.4 12 4 myocardium hypoplasia 0.142556988375163 0.324371591506224 0.732437921166805 0.833333333333333 12.4 12 4 abnormal intestinal enteroendocrine cell morphology 0.142556988375163 0.324371591506224 0.732437921166805 0.833333333333333 12.4 12 4 increased total lung capacity 0.142556988375163 0.324371591506224 0.732437921166805 0.833333333333333 12.4 12 4 ectopic ureteric bud 0.142556988375163 0.324371591506224 0.732437921166805 0.833333333333333 12.4 12 4 abnormal ureteric bud tip morphology 0.142556988375163 0.324371591506224 0.732437921166805 0.833333333333333 12.4 12 4 abnormal endocrine pancreas development 0.142556988375163 0.324371591506224 0.732437921166805 0.833333333333333 12.4 12 4 increased total retina thickness 0.142556988375163 0.324371591506224 0.732437921166805 0.833333333333333 12.4 12 4 increased CD11b-high dendritic cell number 0.142556988375163 0.324371591506224 0.732437921166805 0.833333333333333 12.4 12 4 absent thymus corticomedullary boundary 0.142556988375163 0.324371591506224 0.732437921166805 0.833333333333333 12.4 12 4 increased effector memory T-helper cell number 0.142556988375163 0.324371591506224 0.732437921166805 0.833333333333333 12.4 12 4 abnormal Wolffian duct connection 0.142556988375163 0.324371591506224 0.732437921166805 0.833333333333333 12.4 12 4 increased male germ cell apoptosis 0.142556988375163 0.324371591506224 0.732437921166805 0.833333333333333 12.4 12 4 decreased tear production 0.142556988375163 0.324371591506224 0.732437921166805 0.833333333333333 12.4 12 4 decreased capillary density 0.142556988375163 0.324371591506224 0.732437921166805 0.833333333333333 12.4 12 4 abnormal excitatory synapse morphology 0.142556988375163 0.324371591506224 0.732437921166805 0.833333333333333 12.4 12 4 decreased retinal apoptosis 0.142556988375163 0.324371591506224 0.732437921166805 0.833333333333333 12.4 12 4 liver inflammation 3.58464665736307e-12 1.64267451148364e-10 0.732437921166805 0.833333333333333 12.4 12 4 decreased birth body size 1.24179437324818e-11 5.10572479909891e-10 0.732437921166805 0.833333333333333 12.4 12 4 abnormal inflammatory response 7.71230399446327e-08 1.52256795128789e-06 0.732437921166805 0.833333333333333 12.4 12 4 epidermal hyperplasia 9.54481279148428e-07 1.47470321856007e-05 0.732437921166805 0.833333333333333 12.4 12 4 absent mesoderm 9.54481279148428e-07 1.47470321856007e-05 0.732437921166805 0.833333333333333 12.4 12 4 muscular ventricular septal defect 9.54481279148428e-07 1.47470321856007e-05 0.732437921166805 0.833333333333333 12.4 12 4 abnormal cartilage morphology 4.30399966789155e-05 0.000449944593222083 0.732437921166805 0.833333333333333 12.4 12 4 skin edema 4.30399966789155e-05 0.000449944593222083 0.732437921166805 0.833333333333333 12.4 12 4 heart right ventricle hypertrophy 0.000155509045909567 0.0013815312560716 0.732437921166805 0.833333333333333 12.4 12 4 emphysema 0.000568615277161848 0.00417236136265515 0.732437921166805 0.833333333333333 12.4 12 4 abnormal spleen marginal zone morphology 0.000568615277161848 0.00417236136265515 0.732437921166805 0.833333333333333 12.4 12 4 liver hemorrhage 0.000568615277161848 0.00417236136265515 0.732437921166805 0.833333333333333 12.4 12 4 abnormal optic cup morphology 0.000568615277161848 0.00417236136265515 0.732437921166805 0.833333333333333 12.4 12 4 cortical renal glomerulopathies 0.0080754566331257 0.0373030610490254 0.732437921166805 0.833333333333333 12.4 12 4 abnormal radius morphology 0.0080754566331257 0.0373030610490254 0.732437921166805 0.833333333333333 12.4 12 4 abnormal iron level 0.0080754566331257 0.0373030610490254 0.732437921166805 0.833333333333333 12.4 12 4 eye inflammation 0.0080754566331257 0.0373030610490254 0.732437921166805 0.833333333333333 12.4 12 4 abnormal bile duct morphology 0.0080754566331257 0.0373030610490254 0.732437921166805 0.833333333333333 12.4 12 4 absent allantois 0.0080754566331257 0.0373030610490254 0.732437921166805 0.833333333333333 12.4 12 4 abnormal redox activity 0.0080754566331257 0.0373030610490254 0.732437921166805 0.833333333333333 12.4 12 4 increased circulating glycerol level 0.0080754566331257 0.0373030610490254 0.732437921166805 0.833333333333333 12.4 12 4 long tibia 0.0080754566331257 0.0373030610490254 0.732437921166805 0.833333333333333 12.4 12 4 abnormal eye anterior chamber morphology 0.0080754566331257 0.0373030610490254 0.732437921166805 0.833333333333333 12.4 12 4 increased susceptibility to autoimmune disorder 0.0080754566331257 0.0373030610490254 0.732437921166805 0.833333333333333 12.4 12 4 abnormal glycogen homeostasis 0.0080754566331257 0.0373030610490254 0.732437921166805 0.833333333333333 12.4 12 4 decreased pulmonary respiratory rate 0.0080754566331257 0.0373030610490254 0.732437921166805 0.833333333333333 12.4 12 4 increased gastrointestinal tumor incidence 0.0080754566331257 0.0373030610490254 0.732437921166805 0.833333333333333 12.4 12 4 impaired leukocyte tethering or rolling 0.0080754566331257 0.0373030610490254 0.732437921166805 0.833333333333333 12.4 12 4 increased spleen weight 1.95373506852131e-11 7.65341099676657e-10 0.731141570863855 0.831858407079646 12.4 12 4 ataxia 2.5983842956776e-19 2.93794587977183e-17 0.730987549045683 0.831683168316832 12.4 12 4 decreased birth weight 8.17452783062026e-10 2.32390148327633e-08 0.730895946595928 0.831578947368421 12.4 12 4 abnormal spermatogenesis 1.06444108424895e-17 9.99168753611046e-16 0.730845664816443 0.831521739130435 12.4 12 4 anophthalmia 2.84555419707156e-09 7.04310056240348e-08 0.730791993254071 0.831460674157303 12.4 12 4 abnormal embryo development 2.14036164393846e-13 1.10919783110352e-11 0.730283691986903 0.830882352941177 12.4 12 4 increased hemoglobin content 1.50390717367079e-06 2.23341438477975e-05 0.72995508075607 0.830508474576271 12.4 12 4 atrioventricular septal defect 5.32451782379647e-06 7.12082692832995e-05 0.729674004483157 0.830188679245283 12.4 12 4 increased monocyte cell number 3.69348625189599e-10 1.10030503611872e-08 0.729508169482138 0.83 12.4 12 4 enlarged liver 3.69348625189599e-10 1.10030503611872e-08 0.729508169482138 0.83 12.4 12 4 hemorrhage 5.99688357641613e-22 9.94483193089008e-20 0.729321164055457 0.829787234042553 12.4 12 4 abnormal developmental patterning 1.55825209008808e-08 3.43022307441957e-07 0.728865053258674 0.829268292682927 12.4 12 4 thick ventricular wall 6.79289533353204e-05 0.000669201074937068 0.728865053258674 0.829268292682927 12.4 12 4 abnormal liver development 0.000245666947007471 0.00205065949892981 0.728252561617281 0.828571428571429 12.4 12 4 thick pulmonary interalveolar septum 0.000245666947007471 0.00205065949892981 0.728252561617281 0.828571428571429 12.4 12 4 abnormal midbrain development 0.000245666947007471 0.00205065949892981 0.728252561617281 0.828571428571429 12.4 12 4 abnormal embryonic epiblast morphology 0.000245666947007471 0.00205065949892981 0.728252561617281 0.828571428571429 12.4 12 4 holoprosencephaly 0.000245666947007471 0.00205065949892981 0.728252561617281 0.828571428571429 12.4 12 4 increased red blood cell distribution width 0.000245666947007471 0.00205065949892981 0.728252561617281 0.828571428571429 12.4 12 4 decreased bone mineralization 0.000245666947007471 0.00205065949892981 0.728252561617281 0.828571428571429 12.4 12 4 decreased lymphocyte cell number 1.81725518083588e-12 8.6103281187224e-11 0.727860184159513 0.828125 12.4 12 4 decreased circulating LDL cholesterol level 6.70001346375197e-07 1.08929957458059e-05 0.727860184159513 0.828125 12.4 12 4 short limbs 7.00218131636742e-09 1.658850097568e-07 0.727386625158758 0.827586206896552 12.4 12 4 glomerulosclerosis 2.36205658259367e-06 3.37679066046078e-05 0.727386625158758 0.827586206896552 12.4 12 4 decreased granulocyte number 0.000899438200003 0.00622351188458265 0.727386625158758 0.827586206896552 12.4 12 4 decreased trophoblast giant cell number 0.000899438200003 0.00622351188458265 0.727386625158758 0.827586206896552 12.4 12 4 abnormal behavior 2.83797603448989e-25 7.05946538579359e-23 0.727168583604454 0.827338129496403 12.4 12 4 increased circulating alkaline phosphatase level 2.62967485730337e-15 1.67726056603644e-13 0.727012455084088 0.827160493827161 12.4 12 4 delayed bone ossification 8.52891486200009e-08 1.66397456621374e-06 0.726578417797471 0.826666666666667 12.4 12 4 abnormal neurocranium morphology 8.52891486200009e-08 1.66397456621374e-06 0.726578417797471 0.826666666666667 12.4 12 4 hydroencephaly 3.39757227678155e-11 1.26141209529763e-09 0.726068895765355 0.826086956521739 12.4 12 4 abnormal sternum morphology 2.98691166331436e-07 5.19576416957656e-06 0.726068895765355 0.826086956521739 12.4 12 4 abnormal myelin sheath morphology 2.97744089650947e-05 0.000326992681239175 0.726068895765355 0.826086956521739 12.4 12 4 abnormal blood vessel physiology 0.00335158833267452 0.0183450920777108 0.726068895765355 0.826086956521739 12.4 12 4 abnormal nasal cavity morphology 0.00335158833267452 0.0183450920777108 0.726068895765355 0.826086956521739 12.4 12 4 abnormal cardiovascular development 0.00335158833267452 0.0183450920777108 0.726068895765355 0.826086956521739 12.4 12 4 abnormal corneal stroma morphology 0.00335158833267452 0.0183450920777108 0.726068895765355 0.826086956521739 12.4 12 4 abnormal hematopoietic stem cell physiology 0.00335158833267452 0.0183450920777108 0.726068895765355 0.826086956521739 12.4 12 4 decreased effector memory CD8-positive, alpha-beta T cell number 0.00335158833267452 0.0183450920777108 0.726068895765355 0.826086956521739 12.4 12 4 increased oxygen consumption 1.0947074893952e-08 2.4868355067311e-07 0.725624545155951 0.825581395348837 12.4 12 4 gliosis 1.04908753081959e-06 1.60098480546855e-05 0.725462321917598 0.825396825396825 12.4 12 4 decreased susceptibility to hepatic steatosis 1.04908753081959e-06 1.60098480546855e-05 0.725462321917598 0.825396825396825 12.4 12 4 increased granulocyte number 1.33248095842016e-07 2.4643467539555e-06 0.724519673370407 0.824324324324324 12.4 12 4 short snout 1.83399185958087e-10 5.73843364868858e-09 0.72429972204273 0.824074074074074 12.4 12 4 abnormal axon morphology 1.83399185958087e-10 5.73843364868858e-09 0.72429972204273 0.824074074074074 12.4 12 4 decreased circulating alanine transaminase level 4.66458208375095e-07 7.83996481981789e-06 0.723821004447196 0.823529411764706 12.4 12 4 abnormal gastrulation 1.30890941963596e-05 0.000155413469276585 0.723821004447196 0.823529411764706 12.4 12 4 abnormal thrombosis 1.30890941963596e-05 0.000155413469276585 0.723821004447196 0.823529411764706 12.4 12 4 lung hemorrhage 0.000386099904236548 0.0030154584357564 0.723821004447196 0.823529411764706 12.4 12 4 increased aggression towards mice 0.012834837237132 0.0537938628936238 0.723821004447196 0.823529411764706 12.4 12 4 abnormal dorsal-ventral axis patterning 0.012834837237132 0.0537938628936238 0.723821004447196 0.823529411764706 12.4 12 4 abnormal ectoplacental cone morphology 0.012834837237132 0.0537938628936238 0.723821004447196 0.823529411764706 12.4 12 4 increased brain size 0.012834837237132 0.0537938628936238 0.723821004447196 0.823529411764706 12.4 12 4 abnormal circulating chemokine level 0.012834837237132 0.0537938628936238 0.723821004447196 0.823529411764706 12.4 12 4 abnormal ductus venosus valve morphology 0.012834837237132 0.0537938628936238 0.723821004447196 0.823529411764706 12.4 12 4 abnormal cell cytoskeleton morphology 0.012834837237132 0.0537938628936238 0.723821004447196 0.823529411764706 12.4 12 4 perinatal lethality, incomplete penetrance 3.31711758001904e-20 4.0250390147792e-18 0.723363469046154 0.823008849557522 12.4 12 4 prenatal lethality 1.63756728589743e-06 2.41032462939044e-05 0.722987109280782 0.82258064516129 12.4 12 4 abnormal dendritic cell physiology 2.85423559122579e-10 8.60595276748383e-09 0.722854621263688 0.822429906542056 12.4 12 4 trabecula carnea hypoplasia 4.65826803854525e-05 0.000481197453449672 0.722672082217914 0.822222222222222 12.4 12 4 small placenta 4.65826803854525e-05 0.000481197453449672 0.722672082217914 0.822222222222222 12.4 12 4 lethality at weaning, complete penetrance 4.65826803854525e-05 0.000481197453449672 0.722672082217914 0.822222222222222 12.4 12 4 decreased inflammatory response 2.65687103600417e-08 5.64756735397092e-07 0.721974522292994 0.821428571428571 12.4 12 4 reddish skin 0.0014140746915904 0.00906574947250288 0.721974522292994 0.821428571428571 12.4 12 4 increased bone resorption 0.0014140746915904 0.00906574947250288 0.721974522292994 0.821428571428571 12.4 12 4 hypoxia 0.0014140746915904 0.00906574947250288 0.721974522292994 0.821428571428571 12.4 12 4 abnormal renal tubule epithelium morphology 0.0014140746915904 0.00906574947250288 0.721974522292994 0.821428571428571 12.4 12 4 decreased white adipose tissue amount 7.2632387391764e-07 1.16940494263439e-05 0.721506011895659 0.82089552238806 12.4 12 4 increased leukocyte cell number 2.85483537823427e-13 1.45527863897561e-11 0.721325069949102 0.820689655172414 12.4 12 4 increased rib number 9.24926162598627e-08 1.78353010035975e-06 0.721169645456547 0.82051282051282 12.4 12 4 increased circulating alanine transaminase level 9.24926162598627e-08 1.78353010035975e-06 0.721169645456547 0.82051282051282 12.4 12 4 increased hepatocyte apoptosis 0.00016692024779454 0.00147763030743387 0.721169645456547 0.82051282051282 12.4 12 4 decreased trabecular bone volume 0.00016692024779454 0.00147763030743387 0.721169645456547 0.82051282051282 12.4 12 4 abnormal interventricular septum morphology 2.04068138493084e-05 0.000231789723516688 0.720718914428136 0.82 12.4 12 4 decreased oocyte number 2.04068138493084e-05 0.000231789723516688 0.720718914428136 0.82 12.4 12 4 abnormal long bone morphology 2.54796150863905e-06 3.6217452872798e-05 0.720430742131284 0.819672131147541 12.4 12 4 increased susceptibility to bacterial infection induced morbidity/mortality 3.22587817063078e-07 5.59189682888088e-06 0.720230622480692 0.819444444444444 12.4 12 4 short tail 4.12408314654646e-08 8.51340815521519e-07 0.720083546592907 0.819277108433735 12.4 12 4 small kidney 1.84028153313463e-08 4.03321613539417e-07 0.719120868054681 0.818181818181818 12.4 12 4 decreased circulating calcium level 8.96779155706948e-06 0.000111816448612583 0.719120868054681 0.818181818181818 12.4 12 4 abnormal platelet physiology 8.96779155706948e-06 0.000111816448612583 0.719120868054681 0.818181818181818 12.4 12 4 omphalocele 7.25670485100386e-05 0.000709275179444876 0.719120868054681 0.818181818181818 12.4 12 4 decreased sensitivity to induced morbidity/mortality 7.25670485100386e-05 0.000709275179444876 0.719120868054681 0.818181818181818 12.4 12 4 enlarged pericardium 0.00060350622932206 0.00438312918376241 0.719120868054681 0.818181818181818 12.4 12 4 belly spot 0.00060350622932206 0.00438312918376241 0.719120868054681 0.818181818181818 12.4 12 4 abnormal skeleton physiology 0.00060350622932206 0.00438312918376241 0.719120868054681 0.818181818181818 12.4 12 4 abnormal basisphenoid bone morphology 0.00527175628269112 0.0266333695901021 0.719120868054681 0.818181818181818 12.4 12 4 abnormal long bone epiphysis morphology 0.00527175628269112 0.0266333695901021 0.719120868054681 0.818181818181818 12.4 12 4 intracerebral hemorrhage 0.00527175628269112 0.0266333695901021 0.719120868054681 0.818181818181818 12.4 12 4 aphakia 0.00527175628269112 0.0266333695901021 0.719120868054681 0.818181818181818 12.4 12 4 abnormal vascular branching morphogenesis 0.00527175628269112 0.0266333695901021 0.719120868054681 0.818181818181818 12.4 12 4 abnormal cochlear sensory epithelium morphology 0.00527175628269112 0.0266333695901021 0.719120868054681 0.818181818181818 12.4 12 4 parakeratosis 0.00527175628269112 0.0266333695901021 0.719120868054681 0.818181818181818 12.4 12 4 prolonged PR interval 0.00527175628269112 0.0266333695901021 0.719120868054681 0.818181818181818 12.4 12 4 abnormal limb posture 0.00527175628269112 0.0266333695901021 0.719120868054681 0.818181818181818 12.4 12 4 abnormal mesenteric lymph node morphology 0.00527175628269112 0.0266333695901021 0.719120868054681 0.818181818181818 12.4 12 4 pulmonary vascular congestion 0.00527175628269112 0.0266333695901021 0.719120868054681 0.818181818181818 12.4 12 4 increased circulating creatine kinase level 0.00527175628269112 0.0266333695901021 0.719120868054681 0.818181818181818 12.4 12 4 increased mammary gland tumor incidence 0.00527175628269112 0.0266333695901021 0.719120868054681 0.818181818181818 12.4 12 4 increased bone volume 0.00527175628269112 0.0266333695901021 0.719120868054681 0.818181818181818 12.4 12 4 abnormal awl hair morphology 0.0515605176034006 0.15479992851663 0.719120868054681 0.818181818181818 12.4 12 4 abnormal large intestine morphology 0.0515605176034006 0.15479992851663 0.719120868054681 0.818181818181818 12.4 12 4 delayed hepatic development 0.0515605176034006 0.15479992851663 0.719120868054681 0.818181818181818 12.4 12 4 abnormal glossopharyngeal ganglion morphology 0.0515605176034006 0.15479992851663 0.719120868054681 0.818181818181818 12.4 12 4 abnormal eye distance/ position 0.0515605176034006 0.15479992851663 0.719120868054681 0.818181818181818 12.4 12 4 impaired myelopoiesis 0.0515605176034006 0.15479992851663 0.719120868054681 0.818181818181818 12.4 12 4 focal hepatic necrosis 0.0515605176034006 0.15479992851663 0.719120868054681 0.818181818181818 12.4 12 4 retinal detachment 0.0515605176034006 0.15479992851663 0.719120868054681 0.818181818181818 12.4 12 4 rectal hemorrhage 0.0515605176034006 0.15479992851663 0.719120868054681 0.818181818181818 12.4 12 4 dilated renal glomerular capsule 0.0515605176034006 0.15479992851663 0.719120868054681 0.818181818181818 12.4 12 4 pathological neovascularization 0.0515605176034006 0.15479992851663 0.719120868054681 0.818181818181818 12.4 12 4 abnormal Bruch membrane morphology 0.0515605176034006 0.15479992851663 0.719120868054681 0.818181818181818 12.4 12 4 increased glycogen level 0.0515605176034006 0.15479992851663 0.719120868054681 0.818181818181818 12.4 12 4 abnormal palate development 0.0515605176034006 0.15479992851663 0.719120868054681 0.818181818181818 12.4 12 4 increased number of Howell-Jolly bodies 0.0515605176034006 0.15479992851663 0.719120868054681 0.818181818181818 12.4 12 4 common atrioventricular valve 0.0515605176034006 0.15479992851663 0.719120868054681 0.818181818181818 12.4 12 4 hypolactation 0.0515605176034006 0.15479992851663 0.719120868054681 0.818181818181818 12.4 12 4 abnormal incisor morphology 3.9513497947249e-06 5.35639379530147e-05 0.717789162743469 0.816666666666667 12.4 12 4 prenatal lethality, complete penetrance 1.95129565569047e-23 3.88307835482404e-21 0.717683775992222 0.816546762589928 12.4 12 4 lung inflammation 3.63204414599397e-12 1.64267451148364e-10 0.717358316907489 0.816176470588235 12.4 12 4 ventricular septal defect 3.63204414599397e-12 1.64267451148364e-10 0.717358316907489 0.816176470588235 12.4 12 4 impaired branching involved in ureteric bud morphogenesis 0.000259762110158442 0.00213606032733595 0.71701817545803 0.815789473684211 12.4 12 4 postnatal growth retardation 1.37218783646495e-49 8.53329310801641e-47 0.716640240514188 0.815359477124183 12.4 12 4 neurodegeneration 1.38898268174486e-05 0.000164528305754301 0.716161522918654 0.814814814814815 12.4 12 4 abnormal trigeminal ganglion morphology 0.00220867888139614 0.0129272675705245 0.716161522918654 0.814814814814815 12.4 12 4 abnormal brain commissure morphology 0.00220867888139614 0.0129272675705245 0.716161522918654 0.814814814814815 12.4 12 4 decreased bone ossification 0.00220867888139614 0.0129272675705245 0.716161522918654 0.814814814814815 12.4 12 4 abnormal vasculogenesis 0.000112538562628436 0.00104066793508637 0.71540448113967 0.813953488372093 12.4 12 4 infertility 1.13029756848011e-09 3.10675712883346e-08 0.714640364203873 0.813084112149533 12.4 12 4 reduced fertility 3.86433160012863e-12 1.73198646041801e-10 0.714522173454811 0.81294964028777 12.4 12 4 decreased caudal vertebrae number 2.69179433007866e-06 3.79367614508253e-05 0.714126973137635 0.8125 12.4 12 4 abnormal vertebral body morphology 0.000937881956666681 0.00637426603062396 0.714126973137635 0.8125 12.4 12 4 scoliosis 0.000937881956666681 0.00637426603062396 0.714126973137635 0.8125 12.4 12 4 failure of primitive streak formation 0.000937881956666681 0.00637426603062396 0.714126973137635 0.8125 12.4 12 4 abnormal lumbar vertebrae morphology 0.000937881956666681 0.00637426603062396 0.714126973137635 0.8125 12.4 12 4 abnormal heart atrium morphology 0.000937881956666681 0.00637426603062396 0.714126973137635 0.8125 12.4 12 4 abnormal tympanic ring morphology 0.0202008800456133 0.0777257372211341 0.714126973137635 0.8125 12.4 12 4 abnormal hair follicle orientation 0.0202008800456133 0.0777257372211341 0.714126973137635 0.8125 12.4 12 4 poor circulation 0.0202008800456133 0.0777257372211341 0.714126973137635 0.8125 12.4 12 4 abnormal meiosis 0.0202008800456133 0.0777257372211341 0.714126973137635 0.8125 12.4 12 4 white spotting 0.0202008800456133 0.0777257372211341 0.714126973137635 0.8125 12.4 12 4 paternal imprinting 0.0202008800456133 0.0777257372211341 0.714126973137635 0.8125 12.4 12 4 impaired muscle relaxation 0.0202008800456133 0.0777257372211341 0.714126973137635 0.8125 12.4 12 4 small pancreas 0.0202008800456133 0.0777257372211341 0.714126973137635 0.8125 12.4 12 4 abnormal level of surface class II molecules 0.0202008800456133 0.0777257372211341 0.714126973137635 0.8125 12.4 12 4 blepharitis 0.0202008800456133 0.0777257372211341 0.714126973137635 0.8125 12.4 12 4 loose skin 0.0202008800456133 0.0777257372211341 0.714126973137635 0.8125 12.4 12 4 decreased creatinine clearance 0.0202008800456133 0.0777257372211341 0.714126973137635 0.8125 12.4 12 4 increased heart left ventricle size 0.0202008800456133 0.0777257372211341 0.714126973137635 0.8125 12.4 12 4 abnormal pulmonary alveolus wall morphology 0.0202008800456133 0.0777257372211341 0.714126973137635 0.8125 12.4 12 4 embryonic lethality between somite formation and embryo turning, incomplete penetrance 0.0202008800456133 0.0777257372211341 0.714126973137635 0.8125 12.4 12 4 decreased midbrain size 0.0202008800456133 0.0777257372211341 0.714126973137635 0.8125 12.4 12 4 decreased startle reflex 2.2610360663722e-10 7.03040901887606e-09 0.713657461649708 0.811965811965812 12.4 12 4 premature death 1.08862004603294e-67 1.35397118225346e-64 0.713552762223828 0.81184668989547 12.4 12 4 preweaning lethality, incomplete penetrance 1.16685190833045e-32 4.46545249534153e-30 0.713455422476419 0.811735941320293 12.4 12 4 small testis 1.79700636164161e-22 3.31115061080259e-20 0.713330844962454 0.811594202898551 12.4 12 4 decreased spleen weight 1.18914700487082e-06 1.79817822165116e-05 0.713330844962454 0.811594202898551 12.4 12 4 azoospermia 1.56776266689466e-13 8.38668738473217e-12 0.713090504381267 0.811320754716981 12.4 12 4 abnormal mesoderm development 2.1431312234411e-05 0.000241223480466504 0.713090504381267 0.811320754716981 12.4 12 4 abnormal placenta development 2.1431312234411e-05 0.000241223480466504 0.713090504381267 0.811320754716981 12.4 12 4 small seminiferous tubules 5.26325665688307e-07 8.75214763603739e-06 0.71264230167581 0.810810810810811 12.4 12 4 malocclusion 0.000402148006632578 0.00310665579657931 0.71264230167581 0.810810810810811 12.4 12 4 abnormal long bone metaphysis morphology 0.000402148006632578 0.00310665579657931 0.71264230167581 0.810810810810811 12.4 12 4 abnormal vocalization 0.000402148006632578 0.00310665579657931 0.71264230167581 0.810810810810811 12.4 12 4 abnormal hair follicle development 0.000402148006632578 0.00310665579657931 0.71264230167581 0.810810810810811 12.4 12 4 increased trabecular bone volume 0.000402148006632578 0.00310665579657931 0.71264230167581 0.810810810810811 12.4 12 4 abnormal liver morphology 6.37357486276234e-15 3.9522222637536e-13 0.711978761357677 0.810055865921788 12.4 12 4 disheveled coat 0.000173707019125042 0.00152146552842796 0.711511123419182 0.80952380952381 12.4 12 4 abnormal muscle morphology 0.000173707019125042 0.00152146552842796 0.711511123419182 0.80952380952381 12.4 12 4 abnormal eye pigmentation 0.00822450152038711 0.0378509667566382 0.711511123419182 0.80952380952381 12.4 12 4 abnormal hematopoietic system physiology 0.00822450152038711 0.0378509667566382 0.711511123419182 0.80952380952381 12.4 12 4 left pulmonary isomerism 0.00822450152038711 0.0378509667566382 0.711511123419182 0.80952380952381 12.4 12 4 vascular ring 0.00822450152038711 0.0378509667566382 0.711511123419182 0.80952380952381 12.4 12 4 impaired coordination 2.4350200607962e-27 7.57139050153818e-25 0.711269195121522 0.809248554913295 12.4 12 4 abnormal testis morphology 5.30864658130273e-10 1.56275246993971e-08 0.710783234801873 0.808695652173913 12.4 12 4 abnormal bone structure 8.82699685487048e-16 6.27347276471152e-14 0.710426833380445 0.808290155440414 12.4 12 4 abnormal lipid homeostasis 4.74919736542478e-11 1.69980265417182e-09 0.709901369746288 0.807692307692308 12.4 12 4 cachexia 4.07066376805167e-09 9.83085060488208e-08 0.709901369746288 0.807692307692308 12.4 12 4 abnormal stomach morphology 0.00342564633973735 0.0183450920777108 0.709901369746288 0.807692307692308 12.4 12 4 abnormal rib morphology 2.12594888067919e-11 8.13584283182999e-10 0.709650963619394 0.807407407407407 12.4 12 4 incomplete embryo turning 1.44293102193631e-05 0.000170512632639742 0.709308302603643 0.807017543859649 12.4 12 4 increased eosinophil cell number 6.34127077006255e-06 8.36812256792073e-05 0.708810891451747 0.806451612903226 12.4 12 4 abnormal eyelid morphology 0.00144857457995125 0.00918045673281205 0.708810891451747 0.806451612903226 12.4 12 4 increased lung adenoma incidence 0.00144857457995125 0.00918045673281205 0.708810891451747 0.806451612903226 12.4 12 4 abnormal postnatal growth/weight/body size 0.00144857457995125 0.00918045673281205 0.708810891451747 0.806451612903226 12.4 12 4 abnormal nose morphology 0.00144857457995125 0.00918045673281205 0.708810891451747 0.806451612903226 12.4 12 4 inner cell mass degeneration 0.00144857457995125 0.00918045673281205 0.708810891451747 0.806451612903226 12.4 12 4 abnormal CD8-positive, alpha beta T cell morphology 0.00144857457995125 0.00918045673281205 0.708810891451747 0.806451612903226 12.4 12 4 decreased double-negative T cell number 0.00144857457995125 0.00918045673281205 0.708810891451747 0.806451612903226 12.4 12 4 enlarged heart 2.226184776882e-18 2.30734776353916e-16 0.708444265128582 0.806034482758621 12.4 12 4 abnormal cranium morphology 3.24221497627695e-11 1.21278342157728e-09 0.708387720770283 0.805970149253731 12.4 12 4 internal hemorrhage 2.79417886960194e-06 3.91578588063933e-05 0.708387720770283 0.805970149253731 12.4 12 4 abnormal forebrain development 1.23398289423235e-06 1.8547023863462e-05 0.708023323794578 0.805555555555556 12.4 12 4 impaired wound healing 0.000619178251555933 0.00447084441435525 0.708023323794578 0.805555555555556 12.4 12 4 abnormal limb bone morphology 0.000619178251555933 0.00447084441435525 0.708023323794578 0.805555555555556 12.4 12 4 short radius 0.000619178251555933 0.00447084441435525 0.708023323794578 0.805555555555556 12.4 12 4 abnormal heart morphology 3.38999938136696e-18 3.44188712700013e-16 0.707706251101432 0.805194805194805 12.4 12 4 increased bone trabecula number 0.000266801342812244 0.00218671611283511 0.70742784580989 0.804878048780488 12.4 12 4 increased insulin sensitivity 9.88929418467744e-12 4.09993654739752e-10 0.70682820364349 0.804195804195804 12.4 12 4 impaired balance 9.46098354579294e-09 2.17909227501481e-07 0.706587171007977 0.803921568627451 12.4 12 4 abnormal response to novel object 5.04094644263989e-05 0.000519027725382235 0.706587171007977 0.803921568627451 12.4 12 4 insulin resistance 7.5013823232699e-11 2.5737501419495e-09 0.705803814942558 0.803030303030303 12.4 12 4 abnormal ovary morphology 1.88074441635677e-06 2.73587820800437e-05 0.705616250814218 0.802816901408451 12.4 12 4 edema 1.2157678139149e-13 6.64664271893038e-12 0.705184417123389 0.802325581395349 12.4 12 4 abnormal pulmonary alveolus morphology 1.43747449083399e-08 3.19260517495495e-07 0.70488085086548 0.801980198019802 12.4 12 4 cleft palate 1.13796084098942e-10 3.7995672375318e-09 0.704482275320744 0.801526717557252 12.4 12 4 decreased circulating alkaline phosphatase level 7.68214564054204e-05 0.000742110185664013 0.703140404320133 0.8 12.4 12 4 abnormal circulating protein level 7.68214564054204e-05 0.000742110185664013 0.703140404320133 0.8 12.4 12 4 perinatal lethality 0.00040766795091772 0.00313469560404275 0.703140404320133 0.8 12.4 12 4 abnormal inner ear vestibule morphology 0.00527313950678404 0.0266333695901021 0.703140404320133 0.8 12.4 12 4 abnormal keratinocyte physiology 0.00527313950678404 0.0266333695901021 0.703140404320133 0.8 12.4 12 4 abnormal cochlear outer hair cell morphology 0.00527313950678404 0.0266333695901021 0.703140404320133 0.8 12.4 12 4 decreased acute inflammation 0.00527313950678404 0.0266333695901021 0.703140404320133 0.8 12.4 12 4 abnormal energy expenditure 0.00527313950678404 0.0266333695901021 0.703140404320133 0.8 12.4 12 4 increased liver glycogen level 0.00527313950678404 0.0266333695901021 0.703140404320133 0.8 12.4 12 4 small gonad 0.0127169310724722 0.0536158746487705 0.703140404320133 0.8 12.4 12 4 increased mammary adenocarcinoma incidence 0.0127169310724722 0.0536158746487705 0.703140404320133 0.8 12.4 12 4 anencephaly 0.0127169310724722 0.0536158746487705 0.703140404320133 0.8 12.4 12 4 abnormal dopamine level 0.0127169310724722 0.0536158746487705 0.703140404320133 0.8 12.4 12 4 abnormal hearing physiology 0.0127169310724722 0.0536158746487705 0.703140404320133 0.8 12.4 12 4 abnormal hair texture 0.0127169310724722 0.0536158746487705 0.703140404320133 0.8 12.4 12 4 abnormal physiological neovascularization 0.0127169310724722 0.0536158746487705 0.703140404320133 0.8 12.4 12 4 abnormal neuron proliferation 0.0127169310724722 0.0536158746487705 0.703140404320133 0.8 12.4 12 4 decreased muscle cell glucose uptake 0.0127169310724722 0.0536158746487705 0.703140404320133 0.8 12.4 12 4 abnormal otic capsule morphology 0.0812096511920294 0.215591256499651 0.703140404320133 0.8 12.4 12 4 increased cranium width 0.0812096511920294 0.215591256499651 0.703140404320133 0.8 12.4 12 4 jaundice 0.0812096511920294 0.215591256499651 0.703140404320133 0.8 12.4 12 4 abnormal epidermis suprabasal layer morphology 0.0812096511920294 0.215591256499651 0.703140404320133 0.8 12.4 12 4 absent trophoblast giant cells 0.0812096511920294 0.215591256499651 0.703140404320133 0.8 12.4 12 4 abnormal mammary gland physiology 0.0812096511920294 0.215591256499651 0.703140404320133 0.8 12.4 12 4 decreased incidence of induced tumors 0.0812096511920294 0.215591256499651 0.703140404320133 0.8 12.4 12 4 abnormal airway responsiveness 0.0812096511920294 0.215591256499651 0.703140404320133 0.8 12.4 12 4 abnormal primordial germ cell migration 0.0812096511920294 0.215591256499651 0.703140404320133 0.8 12.4 12 4 abnormal tibialis anterior morphology 0.0812096511920294 0.215591256499651 0.703140404320133 0.8 12.4 12 4 acrania 0.0812096511920294 0.215591256499651 0.703140404320133 0.8 12.4 12 4 peritoneal inflammation 0.0812096511920294 0.215591256499651 0.703140404320133 0.8 12.4 12 4 bifid ureter 0.0812096511920294 0.215591256499651 0.703140404320133 0.8 12.4 12 4 abnormal submandibular gland morphology 0.0812096511920294 0.215591256499651 0.703140404320133 0.8 12.4 12 4 abnormal reproductive system development 0.0812096511920294 0.215591256499651 0.703140404320133 0.8 12.4 12 4 abnormal plasma membrane morphology 0.0812096511920294 0.215591256499651 0.703140404320133 0.8 12.4 12 4 decreased cochlear inner hair cell number 0.0812096511920294 0.215591256499651 0.703140404320133 0.8 12.4 12 4 decreased thyroxine level 0.0812096511920294 0.215591256499651 0.703140404320133 0.8 12.4 12 4 absent axillary lymph nodes 0.0812096511920294 0.215591256499651 0.703140404320133 0.8 12.4 12 4 crystalluria 0.0812096511920294 0.215591256499651 0.703140404320133 0.8 12.4 12 4 increased T-helper 17 cell number 0.0812096511920294 0.215591256499651 0.703140404320133 0.8 12.4 12 4 abnormal vibrissa follicle morphology 0.0812096511920294 0.215591256499651 0.703140404320133 0.8 12.4 12 4 abnormal heart and great artery attachment 0.0812096511920294 0.215591256499651 0.703140404320133 0.8 12.4 12 4 thick aortic valve 0.0812096511920294 0.215591256499651 0.703140404320133 0.8 12.4 12 4 sinus bradycardia 0.0812096511920294 0.215591256499651 0.703140404320133 0.8 12.4 12 4 increased compact bone area 0.0812096511920294 0.215591256499651 0.703140404320133 0.8 12.4 12 4 decreased macrophage apoptosis 0.0812096511920294 0.215591256499651 0.703140404320133 0.8 12.4 12 4 decreased circulating lactate level 0.0812096511920294 0.215591256499651 0.703140404320133 0.8 12.4 12 4 abnormal skeleton morphology 1.93174860343912e-09 5.05813121163663e-08 0.703140404320133 0.8 12.4 12 4 spleen hypoplasia 9.70802605841506e-09 2.22568800187165e-07 0.703140404320133 0.8 12.4 12 4 abnormal ovarian follicle morphology 0.000176504521008381 0.00154054384564332 0.703140404320133 0.8 12.4 12 4 abnormal cell migration 0.000176504521008381 0.00154054384564332 0.703140404320133 0.8 12.4 12 4 ovary cysts 0.000947831733152852 0.00641559574481012 0.703140404320133 0.8 12.4 12 4 increased carcinoma incidence 0.000947831733152852 0.00641559574481012 0.703140404320133 0.8 12.4 12 4 abnormal artery morphology 0.000947831733152852 0.00641559574481012 0.703140404320133 0.8 12.4 12 4 abnormal synaptic transmission 0.00222272989136759 0.0129789685558142 0.703140404320133 0.8 12.4 12 4 abnormal fat pad morphology 0.00222272989136759 0.0129789685558142 0.703140404320133 0.8 12.4 12 4 audiogenic seizures 0.0314482513743482 0.107751412250263 0.703140404320133 0.8 12.4 12 4 abnormal seizure response to electrical stimulation 0.0314482513743482 0.107751412250263 0.703140404320133 0.8 12.4 12 4 absent egg cylinders 0.0314482513743482 0.107751412250263 0.703140404320133 0.8 12.4 12 4 placental labyrinth hypoplasia 0.0314482513743482 0.107751412250263 0.703140404320133 0.8 12.4 12 4 increased airway responsiveness 0.0314482513743482 0.107751412250263 0.703140404320133 0.8 12.4 12 4 abnormal lymph node B cell domain morphology 0.0314482513743482 0.107751412250263 0.703140404320133 0.8 12.4 12 4 joint inflammation 0.0314482513743482 0.107751412250263 0.703140404320133 0.8 12.4 12 4 arthritis 0.0314482513743482 0.107751412250263 0.703140404320133 0.8 12.4 12 4 increased alcohol consumption 0.0314482513743482 0.107751412250263 0.703140404320133 0.8 12.4 12 4 abnormal glial cell morphology 0.0314482513743482 0.107751412250263 0.703140404320133 0.8 12.4 12 4 abnormal ear development 0.0314482513743482 0.107751412250263 0.703140404320133 0.8 12.4 12 4 abnormal zygomatic bone morphology 0.0314482513743482 0.107751412250263 0.703140404320133 0.8 12.4 12 4 abnormal cerebral aqueduct morphology 0.0314482513743482 0.107751412250263 0.703140404320133 0.8 12.4 12 4 abnormal aorta wall morphology 0.0314482513743482 0.107751412250263 0.703140404320133 0.8 12.4 12 4 liver vascular congestion 0.0314482513743482 0.107751412250263 0.703140404320133 0.8 12.4 12 4 lactation failure 0.0314482513743482 0.107751412250263 0.703140404320133 0.8 12.4 12 4 ostium primum atrial septal defect 0.0314482513743482 0.107751412250263 0.703140404320133 0.8 12.4 12 4 abnormal coronary vessel morphology 0.0314482513743482 0.107751412250263 0.703140404320133 0.8 12.4 12 4 herniated liver 0.0314482513743482 0.107751412250263 0.703140404320133 0.8 12.4 12 4 increased or absent threshold for auditory brainstem response 1.87259573229897e-21 2.74004816711393e-19 0.702532151375219 0.799307958477509 12.4 12 4 abnormal eye morphology 5.21217754971692e-11 1.8390484616909e-09 0.701875763305169 0.798561151079137 12.4 12 4 abnormal lung morphology 1.30395897595751e-09 3.54491579529433e-08 0.701663218596771 0.798319327731092 12.4 12 4 decreased body size 1.46576250417593e-56 1.21536140971255e-53 0.701598429749255 0.798245614035088 12.4 12 4 abnormal renal glomerulus morphology 6.54481911112955e-09 1.5654074556668e-07 0.701527696970775 0.798165137614679 12.4 12 4 decreased bone mineral content 1.04313797485995e-15 7.30931186609615e-14 0.701450162963594 0.798076923076923 12.4 12 4 abnormal muscle physiology 1.66559318364562e-07 3.04644341494006e-06 0.701165290824852 0.797752808988764 12.4 12 4 abnormal visceral yolk sac morphology 8.46135310638742e-07 1.319599739946e-05 0.70091527645836 0.79746835443038 12.4 12 4 abnormal cardiovascular system physiology 1.75728751263526e-10 5.67695154244184e-09 0.700497019341486 0.796992481203007 12.4 12 4 limb grasping 8.64232813540715e-14 4.77728694151673e-12 0.700242847708924 0.796703296703297 12.4 12 4 abnormal thoracic vertebrae morphology 2.23197747875496e-05 0.000249530066445077 0.700160995827251 0.796610169491525 12.4 12 4 decreased total body fat amount 4.83074191893853e-24 1.04491048029214e-21 0.699982588133066 0.796407185628742 12.4 12 4 increased cell proliferation 5.09116643189007e-05 0.000519027725382235 0.699885124670503 0.796296296296296 12.4 12 4 abnormal mandible morphology 5.09116643189007e-05 0.000519027725382235 0.699885124670503 0.796296296296296 12.4 12 4 abnormal small intestine morphology 5.09116643189007e-05 0.000519027725382235 0.699885124670503 0.796296296296296 12.4 12 4 abnormal osteoblast physiology 5.09116643189007e-05 0.000519027725382235 0.699885124670503 0.796296296296296 12.4 12 4 decreased platelet aggregation 5.09116643189007e-05 0.000519027725382235 0.699885124670503 0.796296296296296 12.4 12 4 cardiac hypertrophy 4.97112107785691e-08 1.00533851066415e-06 0.699552953277683 0.795918367346939 12.4 12 4 abnormal long bone hypertrophic chondrocyte zone 0.000116549689811165 0.00106971463006938 0.699552953277683 0.795918367346939 12.4 12 4 absent kidney 0.000116549689811165 0.00106971463006938 0.699552953277683 0.795918367346939 12.4 12 4 hypoglycemia 1.11704449934632e-07 2.11304045028439e-06 0.699360079565724 0.795698924731183 12.4 12 4 lethargy 1.11704449934632e-07 2.11304045028439e-06 0.699360079565724 0.795698924731183 12.4 12 4 teratozoospermia 2.51286943861967e-07 4.41750016153105e-06 0.699145288386496 0.795454545454545 12.4 12 4 cochlear hair cell degeneration 0.000267983339755536 0.00218919066549062 0.699145288386496 0.795454545454545 12.4 12 4 lethality, incomplete penetrance 0.000267983339755536 0.00218919066549062 0.699145288386496 0.795454545454545 12.4 12 4 abnormal seminiferous tubule morphology 3.56996238570162e-11 1.3155972495456e-09 0.698324374153557 0.794520547945205 12.4 12 4 decreased mean corpuscular hemoglobin 6.52952601415697e-06 8.50376751843742e-05 0.697970254288367 0.794117647058823 12.4 12 4 overexpanded pulmonary alveoli 0.00144207348322332 0.00918045673281205 0.697970254288367 0.794117647058823 12.4 12 4 abnormal brown adipose tissue morphology 0.00144207348322332 0.00918045673281205 0.697970254288367 0.794117647058823 12.4 12 4 abnormal locomotor behavior 1.68083779239545e-07 3.06306520775361e-06 0.697408281458827 0.793478260869565 12.4 12 4 abnormal bone mineralization 1.98813598692151e-09 5.15155027861172e-08 0.697329326598479 0.793388429752066 12.4 12 4 decreased bone mineral density 5.47245161948295e-19 6.05009929042837e-17 0.697192788118177 0.793233082706767 12.4 12 4 dermatitis 3.36919209116133e-05 0.000362808022803628 0.697078849110477 0.793103448275862 12.4 12 4 abnormal microglial cell morphology 0.00338684790934211 0.0183450920777108 0.697078849110477 0.793103448275862 12.4 12 4 lordosis 0.00338684790934211 0.0183450920777108 0.697078849110477 0.793103448275862 12.4 12 4 abnormal embryonic erythropoiesis 0.00338684790934211 0.0183450920777108 0.697078849110477 0.793103448275862 12.4 12 4 short sternum 0.00338684790934211 0.0183450920777108 0.697078849110477 0.793103448275862 12.4 12 4 abnormal CD8-positive, alpha-beta T cell physiology 0.00338684790934211 0.0183450920777108 0.697078849110477 0.793103448275862 12.4 12 4 decreased body weight 8.65300685391047e-84 1.43495696994015e-80 0.696466818091731 0.792407108239095 12.4 12 4 decreased circulating cholesterol level 1.97375971624188e-13 1.03362679876877e-11 0.696416384060241 0.792349726775956 12.4 12 4 retinal degeneration 1.12293218852818e-07 2.11613168103322e-06 0.695816025108465 0.791666666666667 12.4 12 4 abnormal digit morphology 4.33843820042966e-06 5.84924933526763e-05 0.695816025108465 0.791666666666667 12.4 12 4 abnormal digestive system morphology 0.00805105793081223 0.0373030610490254 0.695816025108465 0.791666666666667 12.4 12 4 abnormal adrenal gland morphology 0.00805105793081223 0.0373030610490254 0.695816025108465 0.791666666666667 12.4 12 4 abnormal body weight 0.00805105793081223 0.0373030610490254 0.695816025108465 0.791666666666667 12.4 12 4 increased heart weight 1.79191996000036e-10 5.67821770764444e-09 0.695552558230347 0.79136690647482 12.4 12 4 abnormal glucose homeostasis 2.95443753415607e-13 1.48467946792187e-11 0.695413586690241 0.791208791208791 12.4 12 4 decreased compact bone thickness 9.81937875145939e-06 0.000120620763675335 0.695269429644907 0.791044776119403 12.4 12 4 abnormal homeostasis 0.000404787854778888 0.00311736776706651 0.694964353107108 0.790697674418605 12.4 12 4 impaired macrophage phagocytosis 0.000404787854778888 0.00311736776706651 0.694964353107108 0.790697674418605 12.4 12 4 decreased heart weight 1.27717922396129e-06 1.90238522131958e-05 0.694459658587786 0.790123456790123 12.4 12 4 prenatal lethality, incomplete penetrance 6.86234104016359e-21 9.22706666886861e-19 0.693888556894868 0.789473684210526 12.4 12 4 persistence of hyaloid vascular system 0.000936095118410583 0.00637426603062396 0.693888556894868 0.789473684210526 12.4 12 4 abnormal reproductive system physiology 0.000936095118410583 0.00637426603062396 0.693888556894868 0.789473684210526 12.4 12 4 abnormal triglyceride level 0.0194713138455939 0.0770030098424718 0.693888556894868 0.789473684210526 12.4 12 4 shiny skin 0.0194713138455939 0.0770030098424718 0.693888556894868 0.789473684210526 12.4 12 4 abnormal stationary movement 0.0194713138455939 0.0770030098424718 0.693888556894868 0.789473684210526 12.4 12 4 abnormal long term depression 0.0194713138455939 0.0770030098424718 0.693888556894868 0.789473684210526 12.4 12 4 abnormal neurotransmitter level 0.0194713138455939 0.0770030098424718 0.693888556894868 0.789473684210526 12.4 12 4 abnormal neural crest cell migration 0.0194713138455939 0.0770030098424718 0.693888556894868 0.789473684210526 12.4 12 4 abnormal digestive system development 0.0194713138455939 0.0770030098424718 0.693888556894868 0.789473684210526 12.4 12 4 osteoarthritis 0.0194713138455939 0.0770030098424718 0.693888556894868 0.789473684210526 12.4 12 4 oliguria 0.0194713138455939 0.0770030098424718 0.693888556894868 0.789473684210526 12.4 12 4 eyelids fail to open 0.0194713138455939 0.0770030098424718 0.693888556894868 0.789473684210526 12.4 12 4 Leydig cell hypoplasia 0.0194713138455939 0.0770030098424718 0.693888556894868 0.789473684210526 12.4 12 4 decreased fertilization frequency 0.0194713138455939 0.0770030098424718 0.693888556894868 0.789473684210526 12.4 12 4 decreased susceptibility to weight gain 0.0194713138455939 0.0770030098424718 0.693888556894868 0.789473684210526 12.4 12 4 shortened RR interval 0.0194713138455939 0.0770030098424718 0.693888556894868 0.789473684210526 12.4 12 4 embryonic lethality between implantation and somite formation, incomplete penetrance 0.0194713138455939 0.0770030098424718 0.693888556894868 0.789473684210526 12.4 12 4 abnormal skeletal muscle fiber morphology 6.50324053682004e-06 8.49176421802616e-05 0.693237018343793 0.788732394366197 12.4 12 4 abnormal skin morphology 1.47135720399106e-05 0.000172818246136754 0.692486761830434 0.787878787878788 12.4 12 4 abnormal tooth development 0.0021798489439467 0.0128188516502776 0.692486761830434 0.787878787878788 12.4 12 4 abnormal aorta morphology 0.0021798489439467 0.0128188516502776 0.692486761830434 0.787878787878788 12.4 12 4 increased cardiomyocyte apoptosis 0.0021798489439467 0.0128188516502776 0.692486761830434 0.787878787878788 12.4 12 4 abnormal middle ear ossicle morphology 0.0021798489439467 0.0128188516502776 0.692486761830434 0.787878787878788 12.4 12 4 decreased sensitivity to xenobiotic induced morbidity/mortality 0.0021798489439467 0.0128188516502776 0.692486761830434 0.787878787878788 12.4 12 4 hepatic necrosis 0.000264491090793164 0.00217135837738612 0.69192007871928 0.787234042553192 12.4 12 4 decreased neutrophil cell number 9.92204452817791e-09 2.26431979484794e-07 0.691120910229191 0.786324786324786 12.4 12 4 increased circulating triglyceride level 1.78527081300215e-10 5.67821770764444e-09 0.69101729390082 0.786206896551724 12.4 12 4 increased blood urea nitrogen level 1.78527081300215e-10 5.67821770764444e-09 0.69101729390082 0.786206896551724 12.4 12 4 abnormal coat/hair pigmentation 2.2166375256188e-08 4.77392713850802e-07 0.690584325671559 0.785714285714286 12.4 12 4 abnormal neuron differentiation 2.2166375256188e-08 4.77392713850802e-07 0.690584325671559 0.785714285714286 12.4 12 4 short mandible 7.58285011268504e-05 0.000735373865703861 0.690584325671559 0.785714285714286 12.4 12 4 abnormal eye development 7.58285011268504e-05 0.000735373865703861 0.690584325671559 0.785714285714286 12.4 12 4 abnormal seminal vesicle morphology 7.58285011268504e-05 0.000735373865703861 0.690584325671559 0.785714285714286 12.4 12 4 abnormal jaw morphology 0.00512222757735052 0.0264073390645791 0.690584325671559 0.785714285714286 12.4 12 4 abnormal ovulation 0.00512222757735052 0.0264073390645791 0.690584325671559 0.785714285714286 12.4 12 4 abnormal respiration 0.00512222757735052 0.0264073390645791 0.690584325671559 0.785714285714286 12.4 12 4 absent atrioventricular cushions 0.0483574561797606 0.151593159731764 0.690584325671559 0.785714285714286 12.4 12 4 megacephaly 0.0483574561797606 0.151593159731764 0.690584325671559 0.785714285714286 12.4 12 4 translucent skin 0.0483574561797606 0.151593159731764 0.690584325671559 0.785714285714286 12.4 12 4 increased aggression towards males 0.0483574561797606 0.151593159731764 0.690584325671559 0.785714285714286 12.4 12 4 absent visceral yolk sac blood islands 0.0483574561797606 0.151593159731764 0.690584325671559 0.785714285714286 12.4 12 4 increased lactate dehydrogenase level 0.0483574561797606 0.151593159731764 0.690584325671559 0.785714285714286 12.4 12 4 decreased coping response 0.0483574561797606 0.151593159731764 0.690584325671559 0.785714285714286 12.4 12 4 intestinal obstruction 0.0483574561797606 0.151593159731764 0.690584325671559 0.785714285714286 12.4 12 4 decreased CNS synapse formation 0.0483574561797606 0.151593159731764 0.690584325671559 0.785714285714286 12.4 12 4 abnormal glucose tolerance 0.0483574561797606 0.151593159731764 0.690584325671559 0.785714285714286 12.4 12 4 increased lung compliance 0.0483574561797606 0.151593159731764 0.690584325671559 0.785714285714286 12.4 12 4 cataract 6.60898877432153e-09 1.57319230393539e-07 0.690065479446411 0.785123966942149 12.4 12 4 decreased monocyte cell number 2.19651550305084e-05 0.000246267994503268 0.689618473467823 0.784615384615385 12.4 12 4 reduced female fertility 1.08795344806116e-15 7.5174561168115e-14 0.689501905098406 0.78448275862069 12.4 12 4 abnormal cervical vertebrae morphology 0.000172865063601864 0.00151944115091744 0.689353337568758 0.784313725490196 12.4 12 4 kidney cysts 6.41143970091811e-06 8.42987517671211e-05 0.688887558286617 0.783783783783784 12.4 12 4 abnormal branching of the mammary ductal tree 0.00140591288940309 0.00906012516163261 0.688887558286617 0.783783783783784 12.4 12 4 increased circulating phosphate level 0.00140591288940309 0.00906012516163261 0.688887558286617 0.783783783783784 12.4 12 4 impaired skeletal muscle contractility 0.00140591288940309 0.00906012516163261 0.688887558286617 0.783783783783784 12.4 12 4 skin inflammation 0.00140591288940309 0.00906012516163261 0.688887558286617 0.783783783783784 12.4 12 4 abnormal respiratory electron transport chain 0.00140591288940309 0.00906012516163261 0.688887558286617 0.783783783783784 12.4 12 4 abnormal enzyme/coenzyme activity 5.30098089355465e-11 1.85720985531228e-09 0.688584950090576 0.78343949044586 12.4 12 4 atrial septal defect 0.000395460730229634 0.00308372591362449 0.687854743356652 0.782608695652174 12.4 12 4 abnormal pulmonary artery morphology 0.0121843609027509 0.0520408893966227 0.687854743356652 0.782608695652174 12.4 12 4 abnormal innervation pattern to muscle 0.0121843609027509 0.0520408893966227 0.687854743356652 0.782608695652174 12.4 12 4 bidirectional circling 0.0121843609027509 0.0520408893966227 0.687854743356652 0.782608695652174 12.4 12 4 abnormal circulating insulin level 0.0121843609027509 0.0520408893966227 0.687854743356652 0.782608695652174 12.4 12 4 abnormal Wolffian duct morphology 0.0121843609027509 0.0520408893966227 0.687854743356652 0.782608695652174 12.4 12 4 dilated heart 0.0121843609027509 0.0520408893966227 0.687854743356652 0.782608695652174 12.4 12 4 abnormal lens development 0.0121843609027509 0.0520408893966227 0.687854743356652 0.782608695652174 12.4 12 4 abnormal learning/memory/conditioning 0.00011302407663367 0.00104128663194909 0.687159940585584 0.781818181818182 12.4 12 4 abnormal joint morphology 0.00011302407663367 0.00104128663194909 0.687159940585584 0.781818181818182 12.4 12 4 abnormal tooth morphology 3.2664831421606e-05 0.000353277252874978 0.68666055109388 0.78125 12.4 12 4 polydipsia 0.00327247680596753 0.0181298130397422 0.68666055109388 0.78125 12.4 12 4 increased circulating follicle stimulating hormone level 0.00327247680596753 0.0181298130397422 0.68666055109388 0.78125 12.4 12 4 abnormal diaphragm morphology 0.00327247680596753 0.0181298130397422 0.68666055109388 0.78125 12.4 12 4 abnormal serotonin level 0.00327247680596753 0.0181298130397422 0.68666055109388 0.78125 12.4 12 4 abnormal auditory brainstem response waveform shape 0.00327247680596753 0.0181298130397422 0.68666055109388 0.78125 12.4 12 4 decreased grip strength 1.73349447745294e-14 1.01460412062687e-12 0.686284298737116 0.780821917808219 12.4 12 4 neonatal lethality, incomplete penetrance 6.41653090528838e-17 5.60039320242275e-15 0.686237990754745 0.780769230769231 12.4 12 4 sparse hair 2.7907366231131e-06 3.91578588063933e-05 0.685990638361105 0.780487804878049 12.4 12 4 increased tumor growth/size 0.000908527001959415 0.00626896232281289 0.685990638361105 0.780487804878049 12.4 12 4 short ulna 0.000908527001959415 0.00626896232281289 0.685990638361105 0.780487804878049 12.4 12 4 small spleen 8.22249687958447e-07 1.30276821579404e-05 0.685755064652877 0.78021978021978 12.4 12 4 abnormal hindlimb morphology 0.000257404335522445 0.00212369248627557 0.68556189421213 0.78 12.4 12 4 short stride length 0.000257404335522445 0.00212369248627557 0.68556189421213 0.78 12.4 12 4 kidney inflammation 0.000257404335522445 0.00212369248627557 0.68556189421213 0.78 12.4 12 4 testicular atrophy 0.000257404335522445 0.00212369248627557 0.68556189421213 0.78 12.4 12 4 abnormal colon morphology 7.39318225813759e-05 0.000721197681063422 0.685263953362841 0.779661016949153 12.4 12 4 increased neutrophil cell number 5.7142866740326e-10 1.67226918843013e-08 0.684955738691164 0.779310344827586 12.4 12 4 alopecia 5.43267237823261e-07 8.94951823897591e-06 0.684636709469603 0.778947368421053 12.4 12 4 impaired glucose tolerance 6.82866520305816e-16 5.0705387142111e-14 0.684002510250936 0.778225806451613 12.4 12 4 decreased circulating glucose level 1.23769440446413e-17 1.14028327077945e-15 0.683608726422351 0.777777777777778 12.4 12 4 thin ventricular wall 1.21415898042801e-06 1.83043664473617e-05 0.683608726422351 0.777777777777778 12.4 12 4 diluted coat color 0.000167702171458259 0.00147928777128517 0.683608726422351 0.777777777777778 12.4 12 4 irregular heartbeat 0.000588159205370577 0.00430307653929209 0.683608726422351 0.777777777777778 12.4 12 4 decreased osteoclast cell number 0.000588159205370577 0.00430307653929209 0.683608726422351 0.777777777777778 12.4 12 4 abnormal trigeminal nerve morphology 0.00768503244393164 0.0361370854523251 0.683608726422351 0.777777777777778 12.4 12 4 wrinkled skin 0.00768503244393164 0.0361370854523251 0.683608726422351 0.777777777777778 12.4 12 4 abnormal fetal cardiomyocyte proliferation 0.00768503244393164 0.0361370854523251 0.683608726422351 0.777777777777778 12.4 12 4 abnormal megakaryocyte differentiation 0.0294926693511538 0.105255401737439 0.683608726422351 0.777777777777778 12.4 12 4 abnormal heart shape 0.0294926693511538 0.105255401737439 0.683608726422351 0.777777777777778 12.4 12 4 delayed kidney development 0.0294926693511538 0.105255401737439 0.683608726422351 0.777777777777778 12.4 12 4 thick dermal layer 0.0294926693511538 0.105255401737439 0.683608726422351 0.777777777777778 12.4 12 4 blepharoptosis 0.0294926693511538 0.105255401737439 0.683608726422351 0.777777777777778 12.4 12 4 abnormal thyroid cartilage morphology 0.0294926693511538 0.105255401737439 0.683608726422351 0.777777777777778 12.4 12 4 acidosis 0.0294926693511538 0.105255401737439 0.683608726422351 0.777777777777778 12.4 12 4 abnormal body wall morphology 0.0294926693511538 0.105255401737439 0.683608726422351 0.777777777777778 12.4 12 4 darkened coat color 0.0294926693511538 0.105255401737439 0.683608726422351 0.777777777777778 12.4 12 4 decreased lactate dehydrogenase level 0.0294926693511538 0.105255401737439 0.683608726422351 0.777777777777778 12.4 12 4 abnormal sperm axoneme morphology 0.0294926693511538 0.105255401737439 0.683608726422351 0.777777777777778 12.4 12 4 small thoracic cage 0.0294926693511538 0.105255401737439 0.683608726422351 0.777777777777778 12.4 12 4 decreased tumor latency 0.0294926693511538 0.105255401737439 0.683608726422351 0.777777777777778 12.4 12 4 abnormal macrophage chemotaxis 0.0294926693511538 0.105255401737439 0.683608726422351 0.777777777777778 12.4 12 4 abnormal urinary bladder urothelium morphology 0.125780604938694 0.306744367436276 0.683608726422351 0.777777777777778 12.4 12 4 abnormal geniculate ganglion morphology 0.125780604938694 0.306744367436276 0.683608726422351 0.777777777777778 12.4 12 4 dilated uterus 0.125780604938694 0.306744367436276 0.683608726422351 0.777777777777778 12.4 12 4 abnormal lens vesicle development 0.125780604938694 0.306744367436276 0.683608726422351 0.777777777777778 12.4 12 4 multifocal hepatic necrosis 0.125780604938694 0.306744367436276 0.683608726422351 0.777777777777778 12.4 12 4 abnormal lung volume 0.125780604938694 0.306744367436276 0.683608726422351 0.777777777777778 12.4 12 4 abnormal thymus lobule morphology 0.125780604938694 0.306744367436276 0.683608726422351 0.777777777777778 12.4 12 4 abnormal posterior semicircular canal morphology 0.125780604938694 0.306744367436276 0.683608726422351 0.777777777777778 12.4 12 4 abnormal postural reflex 0.125780604938694 0.306744367436276 0.683608726422351 0.777777777777778 12.4 12 4 decreased circulating bicarbonate level 0.125780604938694 0.306744367436276 0.683608726422351 0.777777777777778 12.4 12 4 absent posterior semicircular canal 0.125780604938694 0.306744367436276 0.683608726422351 0.777777777777778 12.4 12 4 priapism 0.125780604938694 0.306744367436276 0.683608726422351 0.777777777777778 12.4 12 4 decreased fear-related response 0.125780604938694 0.306744367436276 0.683608726422351 0.777777777777778 12.4 12 4 abnormal ovary physiology 0.125780604938694 0.306744367436276 0.683608726422351 0.777777777777778 12.4 12 4 impaired febrile response 0.125780604938694 0.306744367436276 0.683608726422351 0.777777777777778 12.4 12 4 abnormal proprioceptive neuron morphology 0.125780604938694 0.306744367436276 0.683608726422351 0.777777777777778 12.4 12 4 abnormal stria vascularis vasculature morphology 0.125780604938694 0.306744367436276 0.683608726422351 0.777777777777778 12.4 12 4 short frontal bone 0.125780604938694 0.306744367436276 0.683608726422351 0.777777777777778 12.4 12 4 abnormal CNS synapse formation 0.125780604938694 0.306744367436276 0.683608726422351 0.777777777777778 12.4 12 4 abnormal posterior eye segment morphology 0.125780604938694 0.306744367436276 0.683608726422351 0.777777777777778 12.4 12 4 abnormal intervertebral disk development 0.125780604938694 0.306744367436276 0.683608726422351 0.777777777777778 12.4 12 4 abnormal oxygen consumption 0.125780604938694 0.306744367436276 0.683608726422351 0.777777777777778 12.4 12 4 absent adrenal gland 0.125780604938694 0.306744367436276 0.683608726422351 0.777777777777778 12.4 12 4 decreased pulmonary ventilation 0.125780604938694 0.306744367436276 0.683608726422351 0.777777777777778 12.4 12 4 increased tidal volume 0.125780604938694 0.306744367436276 0.683608726422351 0.777777777777778 12.4 12 4 enhanced conditioned place preference behavior 0.125780604938694 0.306744367436276 0.683608726422351 0.777777777777778 12.4 12 4 axonal spheroids 0.125780604938694 0.306744367436276 0.683608726422351 0.777777777777778 12.4 12 4 abnormal ventricle myocardium morphology 0.125780604938694 0.306744367436276 0.683608726422351 0.777777777777778 12.4 12 4 increased core body temperature 0.125780604938694 0.306744367436276 0.683608726422351 0.777777777777778 12.4 12 4 decreased bone trabecular spacing 0.125780604938694 0.306744367436276 0.683608726422351 0.777777777777778 12.4 12 4 trigeminal neuroma 0.125780604938694 0.306744367436276 0.683608726422351 0.777777777777778 12.4 12 4 abnormal coronary sinus connection 0.125780604938694 0.306744367436276 0.683608726422351 0.777777777777778 12.4 12 4 cerebellum atrophy 0.125780604938694 0.306744367436276 0.683608726422351 0.777777777777778 12.4 12 4 increased bone mineralization 0.125780604938694 0.306744367436276 0.683608726422351 0.777777777777778 12.4 12 4 adipose tissue inflammation 0.125780604938694 0.306744367436276 0.683608726422351 0.777777777777778 12.4 12 4 abnormal retina morphology 1.80101779113842e-13 9.53198245841877e-12 0.68221360657251 0.776190476190476 12.4 12 4 thrombocytosis 0.0001093590230742 0.00101503943991445 0.681924961086336 0.775862068965517 12.4 12 4 organ of Corti degeneration 0.000381380190086991 0.00298328057497292 0.681615698065435 0.775510204081633 12.4 12 4 abnormal cranial ganglia morphology 0.00487697667336649 0.0254595581846782 0.680458455793677 0.774193548387097 12.4 12 4 decreased susceptibility to bacterial infection induced morbidity/mortality 0.00487697667336649 0.0254595581846782 0.680458455793677 0.774193548387097 12.4 12 4 decreased circulating HDL cholesterol level 1.34520964315902e-08 3.01460269131356e-07 0.679793945582941 0.7734375 12.4 12 4 abnormal trabecular bone morphology 4.51075620080304e-08 9.27314549545253e-07 0.679505432746347 0.773109243697479 12.4 12 4 postnatal lethality, incomplete penetrance 4.35467747200666e-33 1.80537670193609e-30 0.679310381814565 0.772887323943662 12.4 12 4 decreased macrophage cell number 0.00086992320585828 0.00603607803228026 0.67916970871831 0.772727272727273 12.4 12 4 embryonic lethality, incomplete penetrance 0.00086992320585828 0.00603607803228026 0.67916970871831 0.772727272727273 12.4 12 4 abnormal tail movements 0.0182638353285535 0.0730994213672997 0.67916970871831 0.772727272727273 12.4 12 4 decreased airway responsiveness 0.0182638353285535 0.0730994213672997 0.67916970871831 0.772727272727273 12.4 12 4 abnormal chorion morphology 0.0182638353285535 0.0730994213672997 0.67916970871831 0.772727272727273 12.4 12 4 abnormal female reproductive system physiology 0.0182638353285535 0.0730994213672997 0.67916970871831 0.772727272727273 12.4 12 4 failure of palatal shelf elevation 0.0182638353285535 0.0730994213672997 0.67916970871831 0.772727272727273 12.4 12 4 embryonic lethality before implantation, incomplete penetrance 0.0182638353285535 0.0730994213672997 0.67916970871831 0.772727272727273 12.4 12 4 abnormal motor capabilities/coordination/movement 8.89272563705079e-09 2.06735093665083e-07 0.67916970871831 0.772727272727273 12.4 12 4 impaired swimming 4.66205371985411e-05 0.000481197453449672 0.67916970871831 0.772727272727273 12.4 12 4 abnormal tail morphology 4.66205371985411e-05 0.000481197453449672 0.67916970871831 0.772727272727273 12.4 12 4 hunched posture 8.91840948885963e-06 0.000111760924954853 0.678663997840635 0.772151898734177 12.4 12 4 seizures 9.99814536950885e-08 1.92049317425894e-06 0.678468811186093 0.771929824561403 12.4 12 4 weight loss 4.58867904788244e-11 1.65425204805907e-09 0.678028247022985 0.771428571428571 12.4 12 4 abnormal intestinal goblet cell morphology 0.00311013938971116 0.0174011594147251 0.678028247022985 0.771428571428571 12.4 12 4 decreased bone volume 0.00311013938971116 0.0174011594147251 0.678028247022985 0.771428571428571 12.4 12 4 impaired adaptive thermogenesis 0.00311013938971116 0.0174011594147251 0.678028247022985 0.771428571428571 12.4 12 4 male infertility 4.42118892709111e-29 1.57110106516273e-26 0.677978322256987 0.771371769383698 12.4 12 4 oligodactyly 0.000562138115594831 0.00414931324196481 0.677505077079295 0.770833333333333 12.4 12 4 small heart 0.000562138115594831 0.00414931324196481 0.677505077079295 0.770833333333333 12.4 12 4 abnormal phalanx morphology 0.000562138115594831 0.00414931324196481 0.677505077079295 0.770833333333333 12.4 12 4 female infertility 5.76810463502237e-16 4.34792735746004e-14 0.677367400778324 0.770676691729323 12.4 12 4 decreased heart rate 7.46192069980204e-07 1.19366737882685e-05 0.676772639158128 0.77 12.4 12 4 postnatal lethality, complete penetrance 2.78167091965672e-22 4.94243315189007e-20 0.676271697160231 0.769430051813471 12.4 12 4 abnormal skin condition 0.000363961304632037 0.00285150785912502 0.676096542615512 0.769230769230769 12.4 12 4 abnormal heart looping 0.00199133109038399 0.0118930038111169 0.676096542615512 0.769230769230769 12.4 12 4 decreased circulating glycerol level 0.0114314500636063 0.0510057973690059 0.676096542615512 0.769230769230769 12.4 12 4 absent teeth 0.0733240178884523 0.212579830416696 0.676096542615512 0.769230769230769 12.4 12 4 absent myocardial trabeculae 0.0733240178884523 0.212579830416696 0.676096542615512 0.769230769230769 12.4 12 4 increased foot pad pigmentation 0.0733240178884523 0.212579830416696 0.676096542615512 0.769230769230769 12.4 12 4 uterus hypoplasia 0.0733240178884523 0.212579830416696 0.676096542615512 0.769230769230769 12.4 12 4 abnormal digestion 0.0733240178884523 0.212579830416696 0.676096542615512 0.769230769230769 12.4 12 4 abnormal coping response 0.0733240178884523 0.212579830416696 0.676096542615512 0.769230769230769 12.4 12 4 abnormal dopaminergic neuron morphology 0.0733240178884523 0.212579830416696 0.676096542615512 0.769230769230769 12.4 12 4 tracheoesophageal fistula 0.0733240178884523 0.212579830416696 0.676096542615512 0.769230769230769 12.4 12 4 muscle fatigue 0.0733240178884523 0.212579830416696 0.676096542615512 0.769230769230769 12.4 12 4 abnormal retinal inner plexiform layer morphology 0.0733240178884523 0.212579830416696 0.676096542615512 0.769230769230769 12.4 12 4 abnormal exocrine pancreas morphology 0.0733240178884523 0.212579830416696 0.676096542615512 0.769230769230769 12.4 12 4 increased circulating ammonia level 0.0733240178884523 0.212579830416696 0.676096542615512 0.769230769230769 12.4 12 4 hyperalgesia 0.0733240178884523 0.212579830416696 0.676096542615512 0.769230769230769 12.4 12 4 increased circulating thyroxine level 0.0733240178884523 0.212579830416696 0.676096542615512 0.769230769230769 12.4 12 4 orthokeratosis 0.0733240178884523 0.212579830416696 0.676096542615512 0.769230769230769 12.4 12 4 increased prostaglandin level 0.0733240178884523 0.212579830416696 0.676096542615512 0.769230769230769 12.4 12 4 abnormal aorta tunica media morphology 0.0733240178884523 0.212579830416696 0.676096542615512 0.769230769230769 12.4 12 4 decreased cardiac stroke volume 0.0733240178884523 0.212579830416696 0.676096542615512 0.769230769230769 12.4 12 4 hypoactivity 9.24660360942125e-22 1.43755790490221e-19 0.676096542615512 0.769230769230769 12.4 12 4 abnormal neuron morphology 1.08754409111417e-06 1.6545968970315e-05 0.674730691014269 0.767676767676768 12.4 12 4 abnormal organ of Corti morphology 0.00127923302345722 0.00834100169292223 0.674524225074546 0.767441860465116 12.4 12 4 abnormal left-right axis patterning 0.00127923302345722 0.00834100169292223 0.674524225074546 0.767441860465116 12.4 12 4 abnormal fertility/fecundity 2.910790367206e-05 0.00032038013444358 0.674244223320675 0.767123287671233 12.4 12 4 increased susceptibility to parasitic infection 3.67159976796935e-06 5.01818924330976e-05 0.673842887473461 0.766666666666667 12.4 12 4 abnormal heart tube morphology 0.00721180711125835 0.034432572340221 0.673842887473461 0.766666666666667 12.4 12 4 gastrointestinal hemorrhage 0.00721180711125835 0.034432572340221 0.673842887473461 0.766666666666667 12.4 12 4 polyuria 1.90222007549838e-05 0.000217994988906959 0.673462400241686 0.766233766233766 12.4 12 4 cleft secondary palate 2.40841590603028e-06 3.43320032449875e-05 0.673219536051191 0.765957446808511 12.4 12 4 pulmonary hypoplasia 0.000824088641112616 0.00576628527242313 0.673219536051191 0.765957446808511 12.4 12 4 abnormal kidney morphology 1.35585719196475e-10 4.43775626975304e-09 0.673005815563556 0.765714285714286 12.4 12 4 increased sacral vertebrae number 9.97334090443548e-05 0.000937946521730936 0.672927340072002 0.765625 12.4 12 4 microphthalmia 2.26740626219491e-09 5.75527865021412e-08 0.672119504129539 0.764705882352941 12.4 12 4 abnormal gluconeogenesis 0.000532156969264333 0.0039751965797148 0.672119504129539 0.764705882352941 12.4 12 4 cochlear inner hair cell degeneration 0.000532156969264333 0.0039751965797148 0.672119504129539 0.764705882352941 12.4 12 4 abnormal endoderm development 0.0045776191912977 0.0239470614897014 0.672119504129539 0.764705882352941 12.4 12 4 increased width of hypertrophic chondrocyte zone 0.0045776191912977 0.0239470614897014 0.672119504129539 0.764705882352941 12.4 12 4 abnormal nervous system development 0.0045776191912977 0.0239470614897014 0.672119504129539 0.764705882352941 12.4 12 4 decreased osteoblast cell number 0.0045776191912977 0.0239470614897014 0.672119504129539 0.764705882352941 12.4 12 4 abnormal vagus nerve morphology 0.0441405191731779 0.139694073083053 0.672119504129539 0.764705882352941 12.4 12 4 decreased vasoconstriction 0.0441405191731779 0.139694073083053 0.672119504129539 0.764705882352941 12.4 12 4 abnormal duodenum morphology 0.0441405191731779 0.139694073083053 0.672119504129539 0.764705882352941 12.4 12 4 abnormal involuntary movement 0.0441405191731779 0.139694073083053 0.672119504129539 0.764705882352941 12.4 12 4 enhanced behavioral response to cocaine 0.0441405191731779 0.139694073083053 0.672119504129539 0.764705882352941 12.4 12 4 cochlear outer hair cell degeneration 4.23424346049607e-05 0.000445356473910528 0.671401427736238 0.763888888888889 12.4 12 4 increased grooming behavior 0.00291977015149007 0.0165442556989329 0.670758938331706 0.763157894736842 12.4 12 4 abnormal compact bone morphology 0.00291977015149007 0.0165442556989329 0.670758938331706 0.763157894736842 12.4 12 4 hyporesponsive to tactile stimuli 0.00291977015149007 0.0165442556989329 0.670758938331706 0.763157894736842 12.4 12 4 abnormal myocardial fiber morphology 2.2902665268988e-06 3.28359538078431e-05 0.670520488655797 0.762886597938144 12.4 12 4 syndactyly 0.000223232167515421 0.00189400410671531 0.670366910898432 0.76271186440678 12.4 12 4 increased circulating insulin level 1.4254410754191e-09 3.81267169366131e-08 0.670180697867627 0.7625 12.4 12 4 abnormal social investigation 1.80475276937384e-05 0.000207839005269326 0.670180697867627 0.7625 12.4 12 4 abnormal hair follicle morphology 0.000144943220030986 0.0013110773084621 0.669657527923936 0.761904761904762 12.4 12 4 abnormal scapula morphology 0.0270927056391445 0.0980976787152428 0.669657527923936 0.761904761904762 12.4 12 4 trunk curl 0.0270927056391445 0.0980976787152428 0.669657527923936 0.761904761904762 12.4 12 4 abnormal associative learning 0.0270927056391445 0.0980976787152428 0.669657527923936 0.761904761904762 12.4 12 4 dry skin 0.0270927056391445 0.0980976787152428 0.669657527923936 0.761904761904762 12.4 12 4 increased keratinocyte proliferation 0.0270927056391445 0.0980976787152428 0.669657527923936 0.761904761904762 12.4 12 4 complete atrioventricular septal defect 0.0270927056391445 0.0980976787152428 0.669657527923936 0.761904761904762 12.4 12 4 increased circulating cholesterol level 2.69802833397787e-10 8.23477973100609e-09 0.669181918884217 0.761363636363636 12.4 12 4 maternal effect 9.424315280429e-05 0.000887991828032846 0.669032847394156 0.761194029850746 12.4 12 4 increased bone mineral density 4.25003315930369e-07 7.19180781208702e-06 0.66891675632225 0.761061946902655 12.4 12 4 delayed wound healing 0.00120129071718267 0.00786371226050499 0.6687476671523 0.760869565217391 12.4 12 4 no abnormal phenotype detected 2.12956453376612e-90 1.05945835554864e-86 0.668692603532115 0.760806916426513 12.4 12 4 abnormal spatial learning 1.35466917563944e-09 3.64296170205741e-08 0.668630445825893 0.760736196319018 12.4 12 4 abnormal gait 7.46129634725021e-17 6.3999912633741e-15 0.668438491161939 0.760517799352751 12.4 12 4 decreased respiratory quotient 0.000773970396208063 0.00548504661130358 0.667983384104126 0.76 12.4 12 4 abnormal nest building behavior 0.0168477996069016 0.0692709116068887 0.667983384104126 0.76 12.4 12 4 decreased placenta weight 0.0168477996069016 0.0692709116068887 0.667983384104126 0.76 12.4 12 4 abnormal preimplantation embryo development 0.0168477996069016 0.0692709116068887 0.667983384104126 0.76 12.4 12 4 abnormal myocardium layer morphology 2.60884570378522e-05 0.000287782868654799 0.667538358531772 0.759493670886076 12.4 12 4 abnormal cochlea morphology 0.000499844594922781 0.00380233464792177 0.6673323281742 0.759259259259259 12.4 12 4 abnormal enzyme/coenzyme level 0.000323474169909267 0.00257485439247776 0.666771073062195 0.758620689655172 12.4 12 4 decreased bone strength 0.0105762779625198 0.0473600205792401 0.666771073062195 0.758620689655172 12.4 12 4 abnormal retinal pigmentation 1.11336675894612e-05 0.000134441738489246 0.666771073062195 0.758620689655172 12.4 12 4 small ovary 7.28179418034886e-06 9.3128344594436e-05 0.666438020578148 0.758241758241758 12.4 12 4 abnormal locomotor activation 7.28179418034886e-06 9.3128344594436e-05 0.666438020578148 0.758241758241758 12.4 12 4 abnormal lens morphology 1.14017388193157e-07 2.14051511796587e-06 0.666060734561063 0.7578125 12.4 12 4 abnormal ovarian folliculogenesis 0.00668693887478266 0.032049634780389 0.665852655606186 0.757575757575758 12.4 12 4 respiratory distress 8.00249836632962e-10 2.28807065359137e-08 0.66554474686371 0.757225433526012 12.4 12 4 increased brown adipose tissue amount 0.00425164878779667 0.0226952282395799 0.665132814897423 0.756756756756757 12.4 12 4 abnormal breathing pattern 0.00425164878779667 0.0226952282395799 0.665132814897423 0.756756756756757 12.4 12 4 abnormal humerus morphology 0.00425164878779667 0.0226952282395799 0.665132814897423 0.756756756756757 12.4 12 4 abnormal cornea morphology 3.75739314605028e-05 0.000397724061736173 0.664828266905254 0.756410256410256 12.4 12 4 absent gastric milk in neonates 3.75739314605028e-05 0.000397724061736173 0.664828266905254 0.756410256410256 12.4 12 4 short humerus 0.00271549885354825 0.01543955062446 0.664553430912321 0.75609756097561 12.4 12 4 palatal shelves fail to meet at midline 0.00271549885354825 0.01543955062446 0.664553430912321 0.75609756097561 12.4 12 4 lethality at weaning, incomplete penetrance 0.00271549885354825 0.01543955062446 0.664553430912321 0.75609756097561 12.4 12 4 altered response to myocardial infarction 0.00174083011645665 0.0108665367997137 0.66407704852457 0.755555555555556 12.4 12 4 increased anxiety-related response 4.64475800926126e-08 9.47035700658802e-07 0.663936532856241 0.755395683453237 12.4 12 4 increased circulating LDL cholesterol level 0.00111947505257735 0.00741596323112158 0.663678442853187 0.755102040816326 12.4 12 4 respiratory failure 1.32277480502434e-08 2.97773966289417e-07 0.663559653083569 0.754966887417219 12.4 12 4 abnormal coat/ hair morphology 0.000721804135762819 0.00512264704054212 0.663340004075597 0.754716981132076 12.4 12 4 enlarged kidney 0.000721804135762819 0.00512264704054212 0.663340004075597 0.754716981132076 12.4 12 4 abnormal circulating amino acid level 0.000466454528535195 0.00355376918753843 0.663049065477318 0.754385964912281 12.4 12 4 decreased percent body fat/body weight 8.27812791221572e-05 0.00079505186029485 0.662204147904235 0.753424657534247 12.4 12 4 abnormal skeleton development 3.5149114213928e-05 0.000376868196582525 0.661906862091483 0.753086419753086 12.4 12 4 cardiac fibrosis 2.29382812262639e-05 0.000255869841032877 0.661779204066007 0.752941176470588 12.4 12 4 increased startle reflex 1.49826469308217e-05 0.000174973400189761 0.661663020919226 0.752808988764045 12.4 12 4 neonatal lethality, complete penetrance 4.50277548682909e-22 7.72458898171542e-20 0.659194129050125 0.75 12.4 12 4 increased body weight 1.37868469146064e-11 5.53141640323926e-10 0.659194129050125 0.75 12.4 12 4 abnormal urine homeostasis 9.13672838616657e-06 0.000113354672621393 0.659194129050125 0.75 12.4 12 4 abnormal suckling behavior 2.13829381818751e-05 0.000241223480466504 0.659194129050125 0.75 12.4 12 4 enhanced long term potentiation 0.000669251124405174 0.00480450843277885 0.659194129050125 0.75 12.4 12 4 abnormal snout morphology 0.00103674396316123 0.00693252851710634 0.659194129050125 0.75 12.4 12 4 abnormal brain wave pattern 0.00103674396316123 0.00693252851710634 0.659194129050125 0.75 12.4 12 4 abnormal cardiovascular system morphology 0.00160994021766597 0.0100621263604123 0.659194129050125 0.75 12.4 12 4 hypertension 0.00250716247625406 0.0145205277291781 0.659194129050125 0.75 12.4 12 4 renal interstitial fibrosis 0.00250716247625406 0.0145205277291781 0.659194129050125 0.75 12.4 12 4 decreased blood urea nitrogen level 0.00250716247625406 0.0145205277291781 0.659194129050125 0.75 12.4 12 4 shortened head 0.015373447043675 0.0636826803016513 0.659194129050125 0.75 12.4 12 4 abnormal somite shape 0.015373447043675 0.0636826803016513 0.659194129050125 0.75 12.4 12 4 absent corpus callosum 0.015373447043675 0.0636826803016513 0.659194129050125 0.75 12.4 12 4 abnormal spleen germinal center morphology 0.015373447043675 0.0636826803016513 0.659194129050125 0.75 12.4 12 4 abnormal hormone level 0.015373447043675 0.0636826803016513 0.659194129050125 0.75 12.4 12 4 corneal vascularization 0.015373447043675 0.0636826803016513 0.659194129050125 0.75 12.4 12 4 apnea 0.0245842698185667 0.0895364146027595 0.659194129050125 0.75 12.4 12 4 abnormal osteoblast morphology 0.0245842698185667 0.0895364146027595 0.659194129050125 0.75 12.4 12 4 abnormal retinal ganglion layer morphology 0.0245842698185667 0.0895364146027595 0.659194129050125 0.75 12.4 12 4 abnormal lung saccule morphology 0.0245842698185667 0.0895364146027595 0.659194129050125 0.75 12.4 12 4 abnormal basioccipital bone morphology 0.0397344621649588 0.132581454909906 0.659194129050125 0.75 12.4 12 4 abnormal fibula morphology 0.0397344621649588 0.132581454909906 0.659194129050125 0.75 12.4 12 4 decreased paired-pulse facilitation 0.0397344621649588 0.132581454909906 0.659194129050125 0.75 12.4 12 4 abnormal lens epithelium morphology 0.0397344621649588 0.132581454909906 0.659194129050125 0.75 12.4 12 4 abnormal postnatal subventricular zone morphology 0.0397344621649588 0.132581454909906 0.659194129050125 0.75 12.4 12 4 kidney atrophy 0.0397344621649588 0.132581454909906 0.659194129050125 0.75 12.4 12 4 decreased circulating VLDL cholesterol level 0.0397344621649588 0.132581454909906 0.659194129050125 0.75 12.4 12 4 abnormal response to tactile stimuli 0.0397344621649588 0.132581454909906 0.659194129050125 0.75 12.4 12 4 abnormal induced retinal neovascularization 0.0397344621649588 0.132581454909906 0.659194129050125 0.75 12.4 12 4 abnormal heart electrocardiography waveform feature 0.0397344621649588 0.132581454909906 0.659194129050125 0.75 12.4 12 4 abnormal adipose tissue distribution 0.109413032888727 0.273120842258614 0.659194129050125 0.75 12.4 12 4 abnormal supraoccipital bone morphology 0.109413032888727 0.273120842258614 0.659194129050125 0.75 12.4 12 4 abnormal rectum morphology 0.109413032888727 0.273120842258614 0.659194129050125 0.75 12.4 12 4 abnormal superior cervical ganglion morphology 0.109413032888727 0.273120842258614 0.659194129050125 0.75 12.4 12 4 abnormal enteric nervous system morphology 0.109413032888727 0.273120842258614 0.659194129050125 0.75 12.4 12 4 abnormal glossopharyngeal nerve morphology 0.109413032888727 0.273120842258614 0.659194129050125 0.75 12.4 12 4 increased litter size 0.109413032888727 0.273120842258614 0.659194129050125 0.75 12.4 12 4 increased growth rate 0.109413032888727 0.273120842258614 0.659194129050125 0.75 12.4 12 4 abnormal corticospinal tract morphology 0.109413032888727 0.273120842258614 0.659194129050125 0.75 12.4 12 4 abnormal AMPA-mediated synaptic currents 0.109413032888727 0.273120842258614 0.659194129050125 0.75 12.4 12 4 increased circulating parathyroid hormone level 0.109413032888727 0.273120842258614 0.659194129050125 0.75 12.4 12 4 abnormal gastrocnemius morphology 0.109413032888727 0.273120842258614 0.659194129050125 0.75 12.4 12 4 abnormal alisphenoid bone morphology 0.109413032888727 0.273120842258614 0.659194129050125 0.75 12.4 12 4 dilated bile duct 0.109413032888727 0.273120842258614 0.659194129050125 0.75 12.4 12 4 decreased circulating ketone body level 0.109413032888727 0.273120842258614 0.659194129050125 0.75 12.4 12 4 absent ovary 0.109413032888727 0.273120842258614 0.659194129050125 0.75 12.4 12 4 vestibular saccular macula degeneration 0.109413032888727 0.273120842258614 0.659194129050125 0.75 12.4 12 4 decreased cochlear nerve compound action potential 0.109413032888727 0.273120842258614 0.659194129050125 0.75 12.4 12 4 small parietal bone 0.109413032888727 0.273120842258614 0.659194129050125 0.75 12.4 12 4 abnormal somatic nervous system physiology 0.109413032888727 0.273120842258614 0.659194129050125 0.75 12.4 12 4 abnormal thymus corticomedullary boundary morphology 0.109413032888727 0.273120842258614 0.659194129050125 0.75 12.4 12 4 impaired behavioral response to cocaine 0.109413032888727 0.273120842258614 0.659194129050125 0.75 12.4 12 4 decreased prostaglandin level 0.109413032888727 0.273120842258614 0.659194129050125 0.75 12.4 12 4 increased skeletal muscle glycogen level 0.109413032888727 0.273120842258614 0.659194129050125 0.75 12.4 12 4 prenatal growth retardation 0.109413032888727 0.273120842258614 0.659194129050125 0.75 12.4 12 4 abnormal respiratory motile cilium morphology 0.109413032888727 0.273120842258614 0.659194129050125 0.75 12.4 12 4 abnormal colon goblet cell morphology 0.109413032888727 0.273120842258614 0.659194129050125 0.75 12.4 12 4 decreased eosinophil cell number 0.000280572652990882 0.00228453183081774 0.659194129050125 0.75 12.4 12 4 abnormal kidney development 0.000432931588947219 0.00330342738498837 0.659194129050125 0.75 12.4 12 4 abnormal retinal blood vessel morphology 0.0061462008026184 0.0304858913190693 0.659194129050125 0.75 12.4 12 4 neonatal lethality 0.00969047627556334 0.0442700821587949 0.659194129050125 0.75 12.4 12 4 abnormal depression-related behavior 0.00969047627556334 0.0442700821587949 0.659194129050125 0.75 12.4 12 4 absent mandible 0.065190365360553 0.191679709024085 0.659194129050125 0.75 12.4 12 4 disorganized retinal layers 0.065190365360553 0.191679709024085 0.659194129050125 0.75 12.4 12 4 abnormal intestinal absorption 0.065190365360553 0.191679709024085 0.659194129050125 0.75 12.4 12 4 abnormal olfaction 0.065190365360553 0.191679709024085 0.659194129050125 0.75 12.4 12 4 abnormal epicardium morphology 0.065190365360553 0.191679709024085 0.659194129050125 0.75 12.4 12 4 decreased cochlear coiling 0.065190365360553 0.191679709024085 0.659194129050125 0.75 12.4 12 4 abnormal molar crown morphology 0.065190365360553 0.191679709024085 0.659194129050125 0.75 12.4 12 4 bowed tibia 0.065190365360553 0.191679709024085 0.659194129050125 0.75 12.4 12 4 small epididymis 0.065190365360553 0.191679709024085 0.659194129050125 0.75 12.4 12 4 absent pre-B cells 0.190920361984188 0.390554605621436 0.659194129050125 0.75 12.4 12 4 clubfoot 0.190920361984188 0.390554605621436 0.659194129050125 0.75 12.4 12 4 absent mammary gland 0.190920361984188 0.390554605621436 0.659194129050125 0.75 12.4 12 4 enlarged pituitary gland 0.190920361984188 0.390554605621436 0.659194129050125 0.75 12.4 12 4 dermal cysts 0.190920361984188 0.390554605621436 0.659194129050125 0.75 12.4 12 4 spinning 0.190920361984188 0.390554605621436 0.659194129050125 0.75 12.4 12 4 poor grooming 0.190920361984188 0.390554605621436 0.659194129050125 0.75 12.4 12 4 abnormal atrial thrombosis 0.190920361984188 0.390554605621436 0.659194129050125 0.75 12.4 12 4 preneoplasia 0.190920361984188 0.390554605621436 0.659194129050125 0.75 12.4 12 4 abnormal secondary sex determination 0.190920361984188 0.390554605621436 0.659194129050125 0.75 12.4 12 4 coarse hair 0.190920361984188 0.390554605621436 0.659194129050125 0.75 12.4 12 4 abnormal thyroid physiology 0.190920361984188 0.390554605621436 0.659194129050125 0.75 12.4 12 4 joint swelling 0.190920361984188 0.390554605621436 0.659194129050125 0.75 12.4 12 4 vascular smooth muscle hypertrophy 0.190920361984188 0.390554605621436 0.659194129050125 0.75 12.4 12 4 altered response to CNS ischemic injury 0.190920361984188 0.390554605621436 0.659194129050125 0.75 12.4 12 4 calcified muscle 0.190920361984188 0.390554605621436 0.659194129050125 0.75 12.4 12 4 abnormal neuron apoptosis 0.190920361984188 0.390554605621436 0.659194129050125 0.75 12.4 12 4 loss of GABAergic neurons 0.190920361984188 0.390554605621436 0.659194129050125 0.75 12.4 12 4 abnormal perineum morphology 0.190920361984188 0.390554605621436 0.659194129050125 0.75 12.4 12 4 liver cysts 0.190920361984188 0.390554605621436 0.659194129050125 0.75 12.4 12 4 pulmonary interstitial fibrosis 0.190920361984188 0.390554605621436 0.659194129050125 0.75 12.4 12 4 increased left ventricle systolic pressure 0.190920361984188 0.390554605621436 0.659194129050125 0.75 12.4 12 4 abnormal skin development 0.190920361984188 0.390554605621436 0.659194129050125 0.75 12.4 12 4 long femur 0.190920361984188 0.390554605621436 0.659194129050125 0.75 12.4 12 4 bowed fibula 0.190920361984188 0.390554605621436 0.659194129050125 0.75 12.4 12 4 abnormal hair follicle melanocyte morphology 0.190920361984188 0.390554605621436 0.659194129050125 0.75 12.4 12 4 absent interparietal bone 0.190920361984188 0.390554605621436 0.659194129050125 0.75 12.4 12 4 increased epididymis weight 0.190920361984188 0.390554605621436 0.659194129050125 0.75 12.4 12 4 non-pigmented tail tip 0.190920361984188 0.390554605621436 0.659194129050125 0.75 12.4 12 4 abnormal canal of Schlemm morphology 0.190920361984188 0.390554605621436 0.659194129050125 0.75 12.4 12 4 ectrodactyly 0.190920361984188 0.390554605621436 0.659194129050125 0.75 12.4 12 4 abnormal olfactory tract morphology 0.190920361984188 0.390554605621436 0.659194129050125 0.75 12.4 12 4 ocular hypertension 0.190920361984188 0.390554605621436 0.659194129050125 0.75 12.4 12 4 abnormal ilium morphology 0.190920361984188 0.390554605621436 0.659194129050125 0.75 12.4 12 4 increased pulmonary ventilation 0.190920361984188 0.390554605621436 0.659194129050125 0.75 12.4 12 4 abnormal thymus epithelium morphology 0.190920361984188 0.390554605621436 0.659194129050125 0.75 12.4 12 4 impaired behavioral response to alcohol 0.190920361984188 0.390554605621436 0.659194129050125 0.75 12.4 12 4 abnormal frontonasal prominence morphology 0.190920361984188 0.390554605621436 0.659194129050125 0.75 12.4 12 4 abnormal olfactory bulb mitral cell layer morphology 0.190920361984188 0.390554605621436 0.659194129050125 0.75 12.4 12 4 decreased hippocampus pyramidal cell number 0.190920361984188 0.390554605621436 0.659194129050125 0.75 12.4 12 4 decreased serotonin level 0.190920361984188 0.390554605621436 0.659194129050125 0.75 12.4 12 4 abnormal lateral plate mesoderm morphology 0.190920361984188 0.390554605621436 0.659194129050125 0.75 12.4 12 4 abnormal brain ependyma morphology 0.190920361984188 0.390554605621436 0.659194129050125 0.75 12.4 12 4 decreased susceptibility to weight loss 0.190920361984188 0.390554605621436 0.659194129050125 0.75 12.4 12 4 decreased quadriceps weight 0.190920361984188 0.390554605621436 0.659194129050125 0.75 12.4 12 4 heart right ventricle hypoplasia 0.190920361984188 0.390554605621436 0.659194129050125 0.75 12.4 12 4 myocardial trabeculae hypoplasia 0.190920361984188 0.390554605621436 0.659194129050125 0.75 12.4 12 4 sinoatrial block 0.190920361984188 0.390554605621436 0.659194129050125 0.75 12.4 12 4 abnormal heart right ventricle pressure 0.190920361984188 0.390554605621436 0.659194129050125 0.75 12.4 12 4 lung situs inversus 0.190920361984188 0.390554605621436 0.659194129050125 0.75 12.4 12 4 decreased lung compliance 0.190920361984188 0.390554605621436 0.659194129050125 0.75 12.4 12 4 increased airway resistance 0.190920361984188 0.390554605621436 0.659194129050125 0.75 12.4 12 4 abnormal maxillary prominence morphology 0.190920361984188 0.390554605621436 0.659194129050125 0.75 12.4 12 4 abnormal bronchus epithelium morphology 0.190920361984188 0.390554605621436 0.659194129050125 0.75 12.4 12 4 abnormal branching involved in ureteric bud morphogenesis 0.190920361984188 0.390554605621436 0.659194129050125 0.75 12.4 12 4 absent Reichert's membrane 0.190920361984188 0.390554605621436 0.659194129050125 0.75 12.4 12 4 impaired neuron differentiation 0.190920361984188 0.390554605621436 0.659194129050125 0.75 12.4 12 4 decreased cranium length 0.190920361984188 0.390554605621436 0.659194129050125 0.75 12.4 12 4 increased circulating lactate level 0.190920361984188 0.390554605621436 0.659194129050125 0.75 12.4 12 4 increased testis apoptosis 0.190920361984188 0.390554605621436 0.659194129050125 0.75 12.4 12 4 retropleural edema 0.190920361984188 0.390554605621436 0.659194129050125 0.75 12.4 12 4 hyperactivity 4.03963162930338e-18 4.01943347115687e-16 0.658601861189343 0.749326145552561 12.4 12 4 reduced male fertility 1.28918335403656e-11 5.21437982628608e-10 0.658226149418627 0.748898678414097 12.4 12 4 decreased litter size 7.63433295870666e-14 4.31600073517791e-12 0.656848242469875 0.747330960854093 12.4 12 4 abnormal lipid level 4.65940121641569e-05 0.000481197453449672 0.656546763070004 0.746987951807229 12.4 12 4 atelectasis 0.000168610994737477 0.00148467203330787 0.656099320932518 0.746478873239437 12.4 12 4 increased total body fat amount 2.7055575434429e-07 4.73948900655931e-06 0.655914556268781 0.746268656716418 12.4 12 4 abnormal femur morphology 0.000259499237840347 0.00213606032733595 0.655914556268781 0.746268656716418 12.4 12 4 skin lesions 0.000399971442457409 0.00310665579657931 0.655706329425521 0.746031746031746 12.4 12 4 abnormal blood homeostasis 2.21789763550365e-06 3.18902911463315e-05 0.655339192622931 0.745614035087719 12.4 12 4 cyanosis 1.01910171757466e-09 2.81668391385217e-08 0.654616392042832 0.744791666666667 12.4 12 4 abnormal excitatory postsynaptic currents 0.000101294286717584 0.000949037808700526 0.653559991194995 0.743589743589744 12.4 12 4 abnormal heart ventricle morphology 0.000101294286717584 0.000949037808700526 0.653559991194995 0.743589743589744 12.4 12 4 dehydration 0.000239105198687368 0.00201960672915052 0.652916089725838 0.742857142857143 12.4 12 4 decreased circulating thyroxine level 0.00881700528476988 0.0404654993466145 0.652916089725838 0.742857142857143 12.4 12 4 small cranium 0.0139244446201976 0.0581646616166943 0.652106020135607 0.741935483870968 12.4 12 4 circling 6.08537765963087e-05 0.000611611189023507 0.651438904002476 0.741176470588235 12.4 12 4 cryptorchism 0.0221355004055342 0.0832888873981619 0.651055929926049 0.740740740740741 12.4 12 4 increased circulating chloride level 0.00210283445916685 0.0125107691903362 0.650404873996123 0.74 12.4 12 4 abnormal coat appearance 0.000337574237779491 0.00268279845519643 0.649640590947949 0.739130434782609 12.4 12 4 abnormal forelimb morphology 0.00326952508106624 0.0181298130397422 0.649640590947949 0.739130434782609 12.4 12 4 abnormal sleep pattern 0.00326952508106624 0.0181298130397422 0.649640590947949 0.739130434782609 12.4 12 4 failure of embryo implantation 0.0354890128683277 0.119538144224733 0.649640590947949 0.739130434782609 12.4 12 4 abnormal postnatal growth 0.0354890128683277 0.119538144224733 0.649640590947949 0.739130434782609 12.4 12 4 abnormal crista ampullaris morphology 0.0354890128683277 0.119538144224733 0.649640590947949 0.739130434782609 12.4 12 4 arrest of spermatogenesis 8.56041546015668e-05 0.000818795539525218 0.648730730176313 0.738095238095238 12.4 12 4 abnormal pancreas morphology 0.00509899437000401 0.0263695394914448 0.648730730176313 0.738095238095238 12.4 12 4 abnormal maternal nurturing 0.000801085228584409 0.00565304824426587 0.648387667918155 0.737704918032787 12.4 12 4 abnormal male meiosis 0.000801085228584409 0.00565304824426587 0.648387667918155 0.737704918032787 12.4 12 4 abnormal motor coordination/ balance 2.19784903637088e-05 0.000246267994503268 0.648096584790022 0.737373737373737 12.4 12 4 impaired righting response 3.35597817419599e-05 0.000362169011206617 0.647629319768544 0.736842105263158 12.4 12 4 increased macrophage cell number 0.0012370815928411 0.00808735995319903 0.647629319768543 0.736842105263158 12.4 12 4 decreased threshold for auditory brainstem response 0.00798090896945517 0.0373030610490254 0.647629319768543 0.736842105263158 12.4 12 4 unresponsive to tactile stimuli 0.0575524647667216 0.171246119745478 0.647629319768543 0.736842105263158 12.4 12 4 delayed sexual maturation 0.0575524647667216 0.171246119745478 0.647629319768543 0.736842105263158 12.4 12 4 abnormal ear morphology 0.0575524647667216 0.171246119745478 0.647629319768543 0.736842105263158 12.4 12 4 abnormal response to novelty 0.0575524647667216 0.171246119745478 0.647629319768543 0.736842105263158 12.4 12 4 decreased liver regeneration 0.0575524647667216 0.171246119745478 0.647629319768543 0.736842105263158 12.4 12 4 increased liver cholesterol level 0.0575524647667216 0.171246119745478 0.647629319768543 0.736842105263158 12.4 12 4 decreased circulating magnesium level 0.0575524647667216 0.171246119745478 0.647629319768543 0.736842105263158 12.4 12 4 increased sensitivity to xenobiotic induced morbidity/mortality 8.67164212363079e-06 0.000108942978699655 0.647208781249213 0.736363636363636 12.4 12 4 abnormal neuromuscular synapse morphology 0.000308700589398919 0.00250535959585582 0.646986830364011 0.736111111111111 12.4 12 4 short maxilla 0.0125461602177964 0.0533024313266756 0.64626875397071 0.735294117647059 12.4 12 4 thin skin 0.0125461602177964 0.0533024313266756 0.64626875397071 0.735294117647059 12.4 12 4 impaired synaptic plasticity 0.0125461602177964 0.0533024313266756 0.64626875397071 0.735294117647059 12.4 12 4 abnormal epidermis stratum corneum morphology 0.00296815144406521 0.0167801743570732 0.645741187640938 0.73469387755102 12.4 12 4 abnormal respiratory system physiology 0.00296815144406521 0.0167801743570732 0.645741187640938 0.73469387755102 12.4 12 4 decreased food intake 0.000183704569155443 0.0016005783389638 0.645287079914046 0.734177215189873 12.4 12 4 delayed eyelid opening 0.0198285728034884 0.0777257372211341 0.644545370626788 0.733333333333333 12.4 12 4 abnormal response to new environment 0.0198285728034884 0.0777257372211341 0.644545370626788 0.733333333333333 12.4 12 4 abnormal lactation 0.0198285728034884 0.0777257372211341 0.644545370626788 0.733333333333333 12.4 12 4 enhanced paired-pulse facilitation 0.0198285728034884 0.0777257372211341 0.644545370626788 0.733333333333333 12.4 12 4 abnormal cellular respiration 0.0198285728034884 0.0777257372211341 0.644545370626788 0.733333333333333 12.4 12 4 absent incisors 0.0948577693946439 0.241020123972601 0.644545370626788 0.733333333333333 12.4 12 4 decreased salivation 0.0948577693946439 0.241020123972601 0.644545370626788 0.733333333333333 12.4 12 4 abnormal enteric neuron morphology 0.0948577693946439 0.241020123972601 0.644545370626788 0.733333333333333 12.4 12 4 abnormal prostate gland morphology 0.0948577693946439 0.241020123972601 0.644545370626788 0.733333333333333 12.4 12 4 abnormal apical ectodermal ridge morphology 0.0948577693946439 0.241020123972601 0.644545370626788 0.733333333333333 12.4 12 4 abnormal cricoid cartilage morphology 0.0948577693946439 0.241020123972601 0.644545370626788 0.733333333333333 12.4 12 4 abnormal pericyte morphology 0.0948577693946439 0.241020123972601 0.644545370626788 0.733333333333333 12.4 12 4 abnormal secondary palate development 0.0948577693946439 0.241020123972601 0.644545370626788 0.733333333333333 12.4 12 4 decreased trabecular bone mass 0.0948577693946439 0.241020123972601 0.644545370626788 0.733333333333333 12.4 12 4 reduced long term potentiation 1.10670887747261e-05 0.000133962935898449 0.643499030739407 0.732142857142857 12.4 12 4 decreased anxiety-related response 4.37444670858437e-06 5.88185739870466e-05 0.643116223463536 0.731707317073171 12.4 12 4 abnormal excitatory postsynaptic potential 0.000167442900008241 0.00147928777128517 0.643116223463536 0.731707317073171 12.4 12 4 scaly skin 0.00719594149344118 0.034422893201798 0.643116223463536 0.731707317073171 12.4 12 4 hemopericardium 0.00719594149344118 0.034422893201798 0.643116223463536 0.731707317073171 12.4 12 4 decreased kidney weight 0.00268613077843851 0.0153603455433697 0.642291715484737 0.730769230769231 12.4 12 4 abnormal kidney cortex morphology 0.0315493197958457 0.107874821982359 0.642291715484737 0.730769230769231 12.4 12 4 abnormal Schwann cell morphology 0.0315493197958457 0.107874821982359 0.642291715484737 0.730769230769231 12.4 12 4 abnormal nerve conduction 0.0315493197958457 0.107874821982359 0.642291715484737 0.730769230769231 12.4 12 4 increased circulating glucose level 1.04457820845309e-06 1.60098480546855e-05 0.64205196493771 0.730496453900709 12.4 12 4 decreased circulating chloride level 0.011261491242637 0.0502925663663548 0.641378071508229 0.72972972972973 12.4 12 4 thick epidermis 0.000601885869026775 0.00438312918376241 0.640360011077264 0.728571428571429 12.4 12 4 abnormal action potential 0.000601885869026775 0.00438312918376241 0.640360011077264 0.728571428571429 12.4 12 4 increased exploration in new environment 0.000232779629575429 0.00196952152574449 0.640204997760615 0.728395061728395 12.4 12 4 deafness 5.40908478833474e-05 0.000544791423237364 0.639218549381939 0.727272727272727 12.4 12 4 hyperglycemia 0.000138326785516334 0.00125809096516227 0.639218549381939 0.727272727272727 12.4 12 4 increased circulating calcium level 0.00242468290081572 0.0140920530742502 0.639218549381939 0.727272727272727 12.4 12 4 abnormal rostral-caudal axis patterning 0.00242468290081572 0.0140920530742502 0.639218549381939 0.727272727272727 12.4 12 4 abnormal germ layer development 0.0506363598007206 0.15479992851663 0.639218549381939 0.727272727272727 12.4 12 4 testis hypoplasia 0.0506363598007206 0.15479992851663 0.639218549381939 0.727272727272727 12.4 12 4 abnormal retinal layer morphology 0.0506363598007206 0.15479992851663 0.639218549381939 0.727272727272727 12.4 12 4 abnormal retinal outer plexiform layer morphology 0.0506363598007206 0.15479992851663 0.639218549381939 0.727272727272727 12.4 12 4 abnormal basement membrane morphology 0.0506363598007206 0.15479992851663 0.639218549381939 0.727272727272727 12.4 12 4 abnormal temporal bone morphology 0.0506363598007206 0.15479992851663 0.639218549381939 0.727272727272727 12.4 12 4 abnormal sperm midpiece morphology 0.0506363598007206 0.15479992851663 0.639218549381939 0.727272727272727 12.4 12 4 abnormal cerebral cortex pyramidal cell morphology 0.0506363598007206 0.15479992851663 0.639218549381939 0.727272727272727 12.4 12 4 abnormal ear position 0.160274007428373 0.339447929738679 0.639218549381939 0.727272727272727 12.4 12 4 abnormal stomach epithelium morphology 0.160274007428373 0.339447929738679 0.639218549381939 0.727272727272727 12.4 12 4 abnormal sebaceous gland morphology 0.160274007428373 0.339447929738679 0.639218549381939 0.727272727272727 12.4 12 4 abnormal enteric ganglia morphology 0.160274007428373 0.339447929738679 0.639218549381939 0.727272727272727 12.4 12 4 abnormal food preference 0.160274007428373 0.339447929738679 0.639218549381939 0.727272727272727 12.4 12 4 abnormal hypothalamus secretion 0.160274007428373 0.339447929738679 0.639218549381939 0.727272727272727 12.4 12 4 secondary sex reversal 0.160274007428373 0.339447929738679 0.639218549381939 0.727272727272727 12.4 12 4 abnormal larynx morphology 0.160274007428373 0.339447929738679 0.639218549381939 0.727272727272727 12.4 12 4 variable body spotting 0.160274007428373 0.339447929738679 0.639218549381939 0.727272727272727 12.4 12 4 abnormal ureter development 0.160274007428373 0.339447929738679 0.639218549381939 0.727272727272727 12.4 12 4 abnormal hair medulla 0.160274007428373 0.339447929738679 0.639218549381939 0.727272727272727 12.4 12 4 abnormal crista ampullaris neuroepithelium morphology 0.160274007428373 0.339447929738679 0.639218549381939 0.727272727272727 12.4 12 4 cyclopia 0.160274007428373 0.339447929738679 0.639218549381939 0.727272727272727 12.4 12 4 abnormal superovulation 0.160274007428373 0.339447929738679 0.639218549381939 0.727272727272727 12.4 12 4 enhanced behavioral response to addictive substance 0.160274007428373 0.339447929738679 0.639218549381939 0.727272727272727 12.4 12 4 abnormal aorta smooth muscle morphology 0.160274007428373 0.339447929738679 0.639218549381939 0.727272727272727 12.4 12 4 palatal shelf hypoplasia 0.160274007428373 0.339447929738679 0.639218549381939 0.727272727272727 12.4 12 4 abnormal palatal shelf elevation 0.160274007428373 0.339447929738679 0.639218549381939 0.727272727272727 12.4 12 4 abnormal dendritic cell chemotaxis 0.160274007428373 0.339447929738679 0.639218549381939 0.727272727272727 12.4 12 4 increased subcutaneous adipose tissue amount 0.160274007428373 0.339447929738679 0.639218549381939 0.727272727272727 12.4 12 4 decreased core body temperature 0.160274007428373 0.339447929738679 0.639218549381939 0.727272727272727 12.4 12 4 abnormal epidermis stratum basale morphology 0.0176999093443119 0.0717406588091308 0.639218549381939 0.727272727272727 12.4 12 4 dilated heart atrium 0.0176999093443119 0.0717406588091308 0.639218549381939 0.727272727272727 12.4 12 4 single kidney 0.0176999093443119 0.0717406588091308 0.639218549381939 0.727272727272727 12.4 12 4 head tossing 0.0176999093443119 0.0717406588091308 0.639218549381939 0.727272727272727 12.4 12 4 decreased exploration in new environment 0.000211076590063806 0.00179505305225202 0.638267331302502 0.726190476190476 12.4 12 4 abnormal retinal pigment epithelium morphology 0.0003222734652324 0.00256940783578716 0.637220991415121 0.725 12.4 12 4 abnormal female reproductive system morphology 0.0100800219158969 0.0460074394785202 0.637220991415121 0.725 12.4 12 4 abnormal epidermal layer morphology 0.00083456231197425 0.00580691958331733 0.636902540145048 0.72463768115942 12.4 12 4 hyperkeratosis 0.00083456231197425 0.00580691958331733 0.636902540145048 0.72463768115942 12.4 12 4 cochlear ganglion degeneration 0.00218405043798395 0.0128283954297168 0.636463297013913 0.724137931034483 12.4 12 4 abnormal circulating glucose level 0.0279660158817077 0.100819513776446 0.636463297013913 0.724137931034483 12.4 12 4 abnormal spinal nerve morphology 0.0279660158817077 0.100819513776446 0.636463297013913 0.724137931034483 12.4 12 4 increased susceptibility to induced arthritis 0.0279660158817077 0.100819513776446 0.636463297013913 0.724137931034483 12.4 12 4 increased retinal apoptosis 0.0279660158817077 0.100819513776446 0.636463297013913 0.724137931034483 12.4 12 4 postnatal lethality 3.58420221759855e-07 6.19146042796971e-06 0.635367835229036 0.72289156626506 12.4 12 4 increased sensitivity to induced morbidity/mortality 8.61608329714575e-08 1.67441462512891e-06 0.635310283794685 0.722826086956522 12.4 12 4 abnormal uterus morphology 0.0157610969383637 0.0650717487704227 0.634779531677898 0.722222222222222 12.4 12 4 abnormal epidermis stratum granulosum morphology 0.0157610969383637 0.0650717487704227 0.634779531677898 0.722222222222222 12.4 12 4 renal hypoplasia 0.0157610969383637 0.0650717487704227 0.634779531677898 0.722222222222222 12.4 12 4 lowered ear position 0.0822249287104401 0.217127930113821 0.634779531677898 0.722222222222222 12.4 12 4 abnormal mammary gland morphology 0.0822249287104401 0.217127930113821 0.634779531677898 0.722222222222222 12.4 12 4 absent spleen 0.0822249287104401 0.217127930113821 0.634779531677898 0.722222222222222 12.4 12 4 abnormal retinal rod cell morphology 0.0822249287104401 0.217127930113821 0.634779531677898 0.722222222222222 12.4 12 4 abnormal phrenic nerve morphology 0.0822249287104401 0.217127930113821 0.634779531677898 0.722222222222222 12.4 12 4 increased circulating renin level 0.0822249287104401 0.217127930113821 0.634779531677898 0.722222222222222 12.4 12 4 decreased activity of thyroid 0.0822249287104401 0.217127930113821 0.634779531677898 0.722222222222222 12.4 12 4 absent ureter 0.0822249287104401 0.217127930113821 0.634779531677898 0.722222222222222 12.4 12 4 jerky movement 0.0822249287104401 0.217127930113821 0.634779531677898 0.722222222222222 12.4 12 4 abnormal pregnancy 0.0822249287104401 0.217127930113821 0.634779531677898 0.722222222222222 12.4 12 4 abnormal blood circulation 0.00900346139231211 0.0412071945048323 0.633643969009422 0.720930232558139 12.4 12 4 abnormal axon guidance 0.00900346139231211 0.0412071945048323 0.633643969009422 0.720930232558139 12.4 12 4 decreased oxygen consumption 0.00900346139231211 0.0412071945048323 0.633643969009422 0.720930232558139 12.4 12 4 abnormal lymphatic vessel morphology 0.0247445859453739 0.0899885344139146 0.631727707006369 0.71875 12.4 12 4 pancreatic islet hyperplasia 0.0247445859453739 0.0899885344139146 0.631727707006369 0.71875 12.4 12 4 corneal opacity 0.00103500123924722 0.00693252851710634 0.631340855991669 0.71830985915493 12.4 12 4 abnormal iris morphology 0.014010239436838 0.0583759976534916 0.631023439774478 0.717948717948718 12.4 12 4 increased vascular permeability 0.014010239436838 0.0583759976534916 0.631023439774478 0.717948717948718 12.4 12 4 abnormal response to injury 0.014010239436838 0.0583759976534916 0.631023439774478 0.717948717948718 12.4 12 4 abnormal eye physiology 0.00270195077821201 0.0154187537963073 0.629896612203452 0.716666666666667 12.4 12 4 improved glucose tolerance 1.3217271330781e-07 2.45357928621774e-06 0.62780393242869 0.714285714285714 12.4 12 4 obese 0.000833279366310187 0.00580691958331733 0.62780393242869 0.714285714285714 12.4 12 4 abnormal dermal layer morphology 0.0218690475503629 0.0832888873981619 0.62780393242869 0.714285714285714 12.4 12 4 abnormal circulating cholesterol level 0.0390406338101821 0.131145950847843 0.62780393242869 0.714285714285714 12.4 12 4 myoclonus 0.0390406338101821 0.131145950847843 0.62780393242869 0.714285714285714 12.4 12 4 increased circulating luteinizing hormone level 0.0390406338101821 0.131145950847843 0.62780393242869 0.714285714285714 12.4 12 4 abnormal retinal inner nuclear layer morphology 0.0390406338101821 0.131145950847843 0.62780393242869 0.714285714285714 12.4 12 4 increased vasoconstriction 0.0713388534794944 0.209263441073399 0.62780393242869 0.714285714285714 12.4 12 4 abnormal embryonic/fetal subventricular zone morphology 0.0713388534794944 0.209263441073399 0.62780393242869 0.714285714285714 12.4 12 4 decreased vocalization 0.0713388534794944 0.209263441073399 0.62780393242869 0.714285714285714 12.4 12 4 irregularly shaped pupil 0.135740422160182 0.324371591506224 0.62780393242869 0.714285714285714 12.4 12 4 extended life span 0.135740422160182 0.324371591506224 0.62780393242869 0.714285714285714 12.4 12 4 abnormal adrenal gland secretion 0.135740422160182 0.324371591506224 0.62780393242869 0.714285714285714 12.4 12 4 abnormal fluid regulation 0.135740422160182 0.324371591506224 0.62780393242869 0.714285714285714 12.4 12 4 absent otoliths 0.135740422160182 0.324371591506224 0.62780393242869 0.714285714285714 12.4 12 4 abnormal kidney medulla morphology 0.135740422160182 0.324371591506224 0.62780393242869 0.714285714285714 12.4 12 4 abnormal ventral body wall morphology 0.135740422160182 0.324371591506224 0.62780393242869 0.714285714285714 12.4 12 4 abnormal voluntary movement 0.135740422160182 0.324371591506224 0.62780393242869 0.714285714285714 12.4 12 4 decreased cornea thickness 0.135740422160182 0.324371591506224 0.62780393242869 0.714285714285714 12.4 12 4 abnormal renal reabsorbtion 0.135740422160182 0.324371591506224 0.62780393242869 0.714285714285714 12.4 12 4 cochlear degeneration 0.282718699932454 0.479308773558192 0.62780393242869 0.714285714285714 12.4 12 4 failure of atrioventricular cushion closure 0.282718699932454 0.479308773558192 0.62780393242869 0.714285714285714 12.4 12 4 cellular necrosis 0.282718699932454 0.479308773558192 0.62780393242869 0.714285714285714 12.4 12 4 absent hair follicles 0.282718699932454 0.479308773558192 0.62780393242869 0.714285714285714 12.4 12 4 abnormal foot pad morphology 0.282718699932454 0.479308773558192 0.62780393242869 0.714285714285714 12.4 12 4 abnormal oculomotor nerve morphology 0.282718699932454 0.479308773558192 0.62780393242869 0.714285714285714 12.4 12 4 prostate gland epithelial hyperplasia 0.282718699932454 0.479308773558192 0.62780393242869 0.714285714285714 12.4 12 4 abnormal liquid preference 0.282718699932454 0.479308773558192 0.62780393242869 0.714285714285714 12.4 12 4 abnormal axial mesoderm 0.282718699932454 0.479308773558192 0.62780393242869 0.714285714285714 12.4 12 4 decreased urine calcium level 0.282718699932454 0.479308773558192 0.62780393242869 0.714285714285714 12.4 12 4 abnormal superior semicircular canal morphology 0.282718699932454 0.479308773558192 0.62780393242869 0.714285714285714 12.4 12 4 detached tectorial membrane 0.282718699932454 0.479308773558192 0.62780393242869 0.714285714285714 12.4 12 4 decreased lateral semicircular canal size 0.282718699932454 0.479308773558192 0.62780393242869 0.714285714285714 12.4 12 4 decreased cholesterol efflux 0.282718699932454 0.479308773558192 0.62780393242869 0.714285714285714 12.4 12 4 abnormal thyroid gland development 0.282718699932454 0.479308773558192 0.62780393242869 0.714285714285714 12.4 12 4 anuria 0.282718699932454 0.479308773558192 0.62780393242869 0.714285714285714 12.4 12 4 abnormal central pattern generator function 0.282718699932454 0.479308773558192 0.62780393242869 0.714285714285714 12.4 12 4 abnormal Purkinje cell innervation 0.282718699932454 0.479308773558192 0.62780393242869 0.714285714285714 12.4 12 4 renal necrosis 0.282718699932454 0.479308773558192 0.62780393242869 0.714285714285714 12.4 12 4 abnormal vestibular saccular macula morphology 0.282718699932454 0.479308773558192 0.62780393242869 0.714285714285714 12.4 12 4 absent deltoid tuberosity 0.282718699932454 0.479308773558192 0.62780393242869 0.714285714285714 12.4 12 4 absent ulna 0.282718699932454 0.479308773558192 0.62780393242869 0.714285714285714 12.4 12 4 increased prostate gland weight 0.282718699932454 0.479308773558192 0.62780393242869 0.714285714285714 12.4 12 4 decreased adrenocorticotropin level 0.282718699932454 0.479308773558192 0.62780393242869 0.714285714285714 12.4 12 4 increased thyroid-stimulating hormone level 0.282718699932454 0.479308773558192 0.62780393242869 0.714285714285714 12.4 12 4 abnormal thyroid hormone level 0.282718699932454 0.479308773558192 0.62780393242869 0.714285714285714 12.4 12 4 abnormal renal/urinary system physiology 0.282718699932454 0.479308773558192 0.62780393242869 0.714285714285714 12.4 12 4 abnormal prostaglandin level 0.282718699932454 0.479308773558192 0.62780393242869 0.714285714285714 12.4 12 4 abnormal cerebellum white matter morphology 0.282718699932454 0.479308773558192 0.62780393242869 0.714285714285714 12.4 12 4 focal dorsal hair loss 0.282718699932454 0.479308773558192 0.62780393242869 0.714285714285714 12.4 12 4 heart right ventricle outflow tract stenosis 0.282718699932454 0.479308773558192 0.62780393242869 0.714285714285714 12.4 12 4 coronary fistula 0.282718699932454 0.479308773558192 0.62780393242869 0.714285714285714 12.4 12 4 thick pulmonary valve 0.282718699932454 0.479308773558192 0.62780393242869 0.714285714285714 12.4 12 4 small lung lobe 0.282718699932454 0.479308773558192 0.62780393242869 0.714285714285714 12.4 12 4 decreased volumetric bone mineral density 0.282718699932454 0.479308773558192 0.62780393242869 0.714285714285714 12.4 12 4 abnormal Mullerian duct topology 0.282718699932454 0.479308773558192 0.62780393242869 0.714285714285714 12.4 12 4 fragmented Meckel's cartilage 0.282718699932454 0.479308773558192 0.62780393242869 0.714285714285714 12.4 12 4 increased susceptibility to injury 0.00636296898592144 0.03086190371091 0.625389301919349 0.711538461538462 12.4 12 4 abnormal cartilage development 0.0110327722897371 0.0493154017443324 0.625013692729007 0.711111111111111 12.4 12 4 abnormal autopod morphology 0.0110327722897371 0.0493154017443324 0.625013692729007 0.711111111111111 12.4 12 4 decreased neuronal precursor cell number 0.0342608861404217 0.11563630159335 0.623753584477537 0.709677419354839 12.4 12 4 abnormal intestine physiology 0.0342608861404217 0.11563630159335 0.623753584477537 0.709677419354839 12.4 12 4 abnormal contextual conditioning behavior 0.00565751024913329 0.0285168323094611 0.62323808564739 0.709090909090909 12.4 12 4 increased stereotypic behavior 0.0619719602748897 0.183846453409408 0.622572232991784 0.708333333333333 12.4 12 4 abnormal primitive streak formation 0.0619719602748897 0.183846453409408 0.622572232991784 0.708333333333333 12.4 12 4 abnormal cardiac muscle contractility 0.0619719602748897 0.183846453409408 0.622572232991784 0.708333333333333 12.4 12 4 increased circulating total protein level 0.0619719602748897 0.183846453409408 0.622572232991784 0.708333333333333 12.4 12 4 abnormal cholesterol homeostasis 0.0170498829368315 0.0700439038899561 0.621679016014752 0.707317073170732 12.4 12 4 distended abdomen 0.00866484044941202 0.0398038607902353 0.620418003811882 0.705882352941177 12.4 12 4 abnormal bone remodeling 0.0300689072479488 0.106004300903342 0.620418003811882 0.705882352941177 12.4 12 4 increased susceptibility to weight gain 0.0300689072479488 0.106004300903342 0.620418003811882 0.705882352941177 12.4 12 4 abnormal skin physiology 0.0300689072479488 0.106004300903342 0.620418003811882 0.705882352941177 12.4 12 4 increased incidence of corneal inflammation 0.115709996210254 0.287254107358289 0.620418003811882 0.705882352941177 12.4 12 4 abnormal touch/ nociception 0.115709996210254 0.287254107358289 0.620418003811882 0.705882352941177 12.4 12 4 abnormal glutamate-mediated receptor currents 0.115709996210254 0.287254107358289 0.620418003811882 0.705882352941177 12.4 12 4 absence seizures 0.115709996210254 0.287254107358289 0.620418003811882 0.705882352941177 12.4 12 4 decreased body fat mass 0.115709996210254 0.287254107358289 0.620418003811882 0.705882352941177 12.4 12 4 short femur 0.000720479596937076 0.00512264704054212 0.619242969713753 0.704545454545455 12.4 12 4 abnormal gametogenesis 0.0150478401197309 0.0626468657704276 0.619242969713753 0.704545454545455 12.4 12 4 abnormal palate morphology 0.0539071408478354 0.161364636412744 0.618503133429747 0.703703703703704 12.4 12 4 abnormal tibia morphology 0.0132796126153159 0.0555644009766161 0.617117908046925 0.702127659574468 12.4 12 4 abnormal innervation 0.0132796126153159 0.0555644009766161 0.617117908046925 0.702127659574468 12.4 12 4 decreased cardiac muscle contractility 0.000303781495186164 0.00246946558586791 0.616938095136655 0.701923076923077 12.4 12 4 impaired ovarian folliculogenesis 0.0231807469857005 0.0848596146091686 0.615247853780116 0.7 12.4 12 4 increased susceptibility to weight loss 0.0231807469857005 0.0848596146091686 0.615247853780116 0.7 12.4 12 4 increased urine glucose level 0.0991278041708352 0.251147622820233 0.615247853780116 0.7 12.4 12 4 abnormal trachea morphology 0.0991278041708352 0.251147622820233 0.615247853780116 0.7 12.4 12 4 enhanced behavioral response to xenobiotic 0.0991278041708352 0.251147622820233 0.615247853780116 0.7 12.4 12 4 abnormal lateral semicircular canal morphology 0.229779497014246 0.447119890864412 0.615247853780116 0.7 12.4 12 4 retarded hair growth 0.229779497014246 0.447119890864412 0.615247853780116 0.7 12.4 12 4 abnormal prostate gland epithelium morphology 0.229779497014246 0.447119890864412 0.615247853780116 0.7 12.4 12 4 abnormal grooming behavior 0.229779497014246 0.447119890864412 0.615247853780116 0.7 12.4 12 4 abnormal pituitary secretion 0.229779497014246 0.447119890864412 0.615247853780116 0.7 12.4 12 4 rhinitis 0.229779497014246 0.447119890864412 0.615247853780116 0.7 12.4 12 4 abnormal gland morphology 0.229779497014246 0.447119890864412 0.615247853780116 0.7 12.4 12 4 ketoaciduria 0.229779497014246 0.447119890864412 0.615247853780116 0.7 12.4 12 4 abnormal PNS synaptic transmission 0.229779497014246 0.447119890864412 0.615247853780116 0.7 12.4 12 4 abnormal neuron specification 0.229779497014246 0.447119890864412 0.615247853780116 0.7 12.4 12 4 impaired social transmission of food preference 0.229779497014246 0.447119890864412 0.615247853780116 0.7 12.4 12 4 increased natural killer cell mediated cytotoxicity 0.229779497014246 0.447119890864412 0.615247853780116 0.7 12.4 12 4 cochlear ganglion hypoplasia 0.229779497014246 0.447119890864412 0.615247853780116 0.7 12.4 12 4 abnormal glial cell physiology 0.229779497014246 0.447119890864412 0.615247853780116 0.7 12.4 12 4 increased atrioventricular cushion size 0.229779497014246 0.447119890864412 0.615247853780116 0.7 12.4 12 4 abnormal hindlimb zeugopod morphology 0.229779497014246 0.447119890864412 0.615247853780116 0.7 12.4 12 4 absent pharyngeal arches 0.229779497014246 0.447119890864412 0.615247853780116 0.7 12.4 12 4 abnormal placental transport 0.229779497014246 0.447119890864412 0.615247853780116 0.7 12.4 12 4 abnormal utricular macula morphology 0.229779497014246 0.447119890864412 0.615247853780116 0.7 12.4 12 4 abnormal deltoid tuberosity morphology 0.229779497014246 0.447119890864412 0.615247853780116 0.7 12.4 12 4 absent coat pigmentation 0.229779497014246 0.447119890864412 0.615247853780116 0.7 12.4 12 4 ascites 0.229779497014246 0.447119890864412 0.615247853780116 0.7 12.4 12 4 abnormal gonadal fat pad morphology 0.229779497014246 0.447119890864412 0.615247853780116 0.7 12.4 12 4 increased susceptibility to atherosclerosis 0.229779497014246 0.447119890864412 0.615247853780116 0.7 12.4 12 4 tachypnea 0.229779497014246 0.447119890864412 0.615247853780116 0.7 12.4 12 4 vascular smooth muscle hyperplasia 0.229779497014246 0.447119890864412 0.615247853780116 0.7 12.4 12 4 abnormal developmental vascular remodeling 0.229779497014246 0.447119890864412 0.615247853780116 0.7 12.4 12 4 abnormal spinal cord dorsal column morphology 0.229779497014246 0.447119890864412 0.615247853780116 0.7 12.4 12 4 abnormal cerebellar granule cell migration 0.229779497014246 0.447119890864412 0.615247853780116 0.7 12.4 12 4 increased kidney iron level 0.229779497014246 0.447119890864412 0.615247853780116 0.7 12.4 12 4 fusion of atlas and odontoid process 0.229779497014246 0.447119890864412 0.615247853780116 0.7 12.4 12 4 abnormal eating behavior 0.00601689915168679 0.029874324630381 0.615247853780116 0.7 12.4 12 4 disorganized myocardium 0.0469533830642191 0.148407293992688 0.615247853780116 0.7 12.4 12 4 abnormal intestinal mucosa morphology 0.0203648814013926 0.0782357412910643 0.61320384097686 0.697674418604651 12.4 12 4 abnormal male reproductive system morphology 0.0203648814013926 0.0782357412910643 0.61320384097686 0.697674418604651 12.4 12 4 abnormal CNS synaptic transmission 0.000606016627813875 0.00439494566089508 0.612584443157692 0.696969696969697 12.4 12 4 absent vibrissae 0.0409473421278167 0.135538834095189 0.612584443157691 0.696969696969697 12.4 12 4 abnormal carpal bone morphology 0.0852588670747617 0.221006271786043 0.611426438539246 0.695652173913043 12.4 12 4 abnormal cochlear ganglion morphology 0.0852588670747617 0.221006271786043 0.611426438539246 0.695652173913043 12.4 12 4 decreased epididymis weight 0.0852588670747617 0.221006271786043 0.611426438539246 0.695652173913043 12.4 12 4 abnormal palatal shelf fusion at midline 0.0852588670747617 0.221006271786043 0.611426438539246 0.695652173913043 12.4 12 4 increased fluid intake 0.0157379584991015 0.0650717487704227 0.609866677216442 0.693877551020408 12.4 12 4 increased liver weight 0.00152187898394124 0.00963275819988252 0.609255179879661 0.693181818181818 12.4 12 4 acanthosis 0.031246907303113 0.107751412250263 0.608486888353961 0.692307692307692 12.4 12 4 decreased body temperature 0.0138440512422658 0.0578774411178758 0.608486888353961 0.692307692307692 12.4 12 4 thick skin 0.0735676941386051 0.212782069933679 0.608486888353961 0.692307692307692 12.4 12 4 no spontaneous movement 0.0735676941386051 0.212782069933679 0.608486888353961 0.692307692307692 12.4 12 4 abnormal mast cell morphology 0.190613316639345 0.390554605621436 0.608486888353961 0.692307692307692 12.4 12 4 short hair 0.190613316639345 0.390554605621436 0.608486888353961 0.692307692307692 12.4 12 4 pup cannibalization 0.190613316639345 0.390554605621436 0.608486888353961 0.692307692307692 12.4 12 4 abnormal otolith morphology 0.190613316639345 0.390554605621436 0.608486888353961 0.692307692307692 12.4 12 4 increased synaptic depression 0.190613316639345 0.390554605621436 0.608486888353961 0.692307692307692 12.4 12 4 anal atresia 0.190613316639345 0.390554605621436 0.608486888353961 0.692307692307692 12.4 12 4 absent lateral semicircular canal 0.190613316639345 0.390554605621436 0.608486888353961 0.692307692307692 12.4 12 4 vestibular hair cell degeneration 0.190613316639345 0.390554605621436 0.608486888353961 0.692307692307692 12.4 12 4 increased circulating thyroid-stimulating hormone level 0.190613316639345 0.390554605621436 0.608486888353961 0.692307692307692 12.4 12 4 abnormal vertebral arch development 0.190613316639345 0.390554605621436 0.608486888353961 0.692307692307692 12.4 12 4 abnormal inhibitory postsynaptic currents 0.00554950054873523 0.0280007760952919 0.607492628732468 0.691176470588235 12.4 12 4 hydronephrosis 0.00227083201461745 0.0132287930593932 0.606877134681067 0.69047619047619 12.4 12 4 increased food intake 0.00227083201461745 0.0132287930593932 0.606877134681067 0.69047619047619 12.4 12 4 abnormal optic nerve morphology 0.0273372395067642 0.098839219873657 0.606877134681067 0.69047619047619 12.4 12 4 abnormal vibrissa morphology 0.0273372395067642 0.098839219873657 0.606877134681067 0.69047619047619 12.4 12 4 decreased liver weight 0.00490243017516008 0.0255656080937331 0.606582391050819 0.690140845070423 12.4 12 4 focal hair loss 0.0636508958734584 0.188265878103719 0.606155520965632 0.689655172413793 12.4 12 4 aphagia 0.0636508958734584 0.188265878103719 0.606155520965632 0.689655172413793 12.4 12 4 absent long term depression 0.0636508958734584 0.188265878103719 0.606155520965632 0.689655172413793 12.4 12 4 decreased insulin secretion 0.0017809331852634 0.0111029355848188 0.605482014831226 0.688888888888889 12.4 12 4 cardiomyopathy 0.0239383474575744 0.0875042458496933 0.605482014831226 0.688888888888889 12.4 12 4 abnormal kidney physiology 0.0209794762534018 0.0804725476951998 0.604261284962614 0.6875 12.4 12 4 abnormal hair shaft morphology 0.0209794762534018 0.0804725476951998 0.604261284962614 0.6875 12.4 12 4 increased dopamine level 0.0551967465695269 0.16502633063906 0.604261284962614 0.6875 12.4 12 4 abnormal long term potentiation 0.0551967465695269 0.16502633063906 0.604261284962614 0.6875 12.4 12 4 vasculature congestion 0.160126058269644 0.339447929738679 0.604261284962614 0.6875 12.4 12 4 delayed hair appearance 0.160126058269644 0.339447929738679 0.604261284962614 0.6875 12.4 12 4 mixed cellular infiltration to dermis 0.160126058269644 0.339447929738679 0.604261284962614 0.6875 12.4 12 4 reduced male mating frequency 0.160126058269644 0.339447929738679 0.604261284962614 0.6875 12.4 12 4 abnormal extraembryonic endoderm formation 0.160126058269644 0.339447929738679 0.604261284962614 0.6875 12.4 12 4 increased thymus weight 0.160126058269644 0.339447929738679 0.604261284962614 0.6875 12.4 12 4 abnormal wound healing 0.160126058269644 0.339447929738679 0.604261284962614 0.6875 12.4 12 4 dystonia 0.160126058269644 0.339447929738679 0.604261284962614 0.6875 12.4 12 4 abnormal Langerhans cell physiology 0.160126058269644 0.339447929738679 0.604261284962614 0.6875 12.4 12 4 dilated respiratory conducting tubes 0.160126058269644 0.339447929738679 0.604261284962614 0.6875 12.4 12 4 decreased adipocyte glucose uptake 0.160126058269644 0.339447929738679 0.604261284962614 0.6875 12.4 12 4 polyphagia 0.0161498767402358 0.0665663933576415 0.602226735181595 0.685185185185185 12.4 12 4 abnormal retinal outer nuclear layer morphology 0.041742376488228 0.135538834095189 0.601370082642219 0.684210526315789 12.4 12 4 irregular coat pigmentation 0.13568193392183 0.324371591506224 0.601370082642219 0.684210526315789 12.4 12 4 short vibrissae 0.13568193392183 0.324371591506224 0.601370082642219 0.684210526315789 12.4 12 4 decreased germ cell number 0.13568193392183 0.324371591506224 0.601370082642219 0.684210526315789 12.4 12 4 increased susceptibility to ischemic brain injury 0.13568193392183 0.324371591506224 0.601370082642219 0.684210526315789 12.4 12 4 increased left ventricle weight 0.13568193392183 0.324371591506224 0.601370082642219 0.684210526315789 12.4 12 4 increased circulating VLDL cholesterol level 0.13568193392183 0.324371591506224 0.601370082642219 0.684210526315789 12.4 12 4 decreased eye pigmentation 0.13568193392183 0.324371591506224 0.601370082642219 0.684210526315789 12.4 12 4 decreased liver glycogen level 0.13568193392183 0.324371591506224 0.601370082642219 0.684210526315789 12.4 12 4 intestinal ulcer 0.11570133993401 0.287254107358289 0.599267390045568 0.681818181818182 12.4 12 4 increased body size 0.11570133993401 0.287254107358289 0.599267390045568 0.681818181818182 12.4 12 4 abnormal circulating lipid level 0.11570133993401 0.287254107358289 0.599267390045568 0.681818181818182 12.4 12 4 rough coat 0.11570133993401 0.287254107358289 0.599267390045568 0.681818181818182 12.4 12 4 increased thermal nociceptive threshold 0.00270254337897085 0.0154187537963073 0.598828366316597 0.681318681318681 12.4 12 4 abnormal food intake 0.00848722858039973 0.0390239946279932 0.598688387736345 0.681159420289855 12.4 12 4 abnormal heart left ventricle morphology 0.00747385641143007 0.0352774531753934 0.598157635619557 0.680555555555556 12.4 12 4 abnormal digestive system physiology 0.0242779382323711 0.0886804278311646 0.597669343672113 0.68 12.4 12 4 abnormal feces composition 0.0991465188379773 0.251147622820233 0.597669343672113 0.68 12.4 12 4 abnormal nervous system electrophysiology 0.00451256048461324 0.0237064291562311 0.596413735807256 0.678571428571429 12.4 12 4 abnormal eye electrophysiology 0.000792282417720587 0.00560683503294441 0.595635466469534 0.677685950413223 12.4 12 4 abnormal body temperature homeostasis 0.0736076266041934 0.212782069933679 0.595401148819467 0.67741935483871 12.4 12 4 abnormal retinal photoreceptor layer morphology 0.0736076266041934 0.212782069933679 0.595401148819467 0.67741935483871 12.4 12 4 abnormal podocyte morphology 0.0736076266041934 0.212782069933679 0.595401148819467 0.67741935483871 12.4 12 4 abnormal retinal photoreceptor morphology 0.0636931605129949 0.188278950417201 0.594567253653054 0.676470588235294 12.4 12 4 increased insulin secretion 0.0552387220365498 0.165052637917018 0.593868584729842 0.675675675675676 12.4 12 4 decreased circulating phosphate level 0.0479997018085084 0.151521901330793 0.593274716145112 0.675 12.4 12 4 head bobbing 0.0479997018085084 0.151521901330793 0.593274716145112 0.675 12.4 12 4 abnormal response/metabolism to endogenous compounds 0.0075497611225173 0.0356019541085532 0.589523204841575 0.670731707317073 12.4 12 4 small lens 0.0627333148584582 0.185883407635991 0.585950336933444 0.666666666666667 12.4 12 4 abnormal circulating hormone level 0.0627333148584582 0.185883407635991 0.585950336933444 0.666666666666667 12.4 12 4 abnormal systemic arterial blood pressure 0.0723770237000501 0.212058711959805 0.585950336933444 0.666666666666667 12.4 12 4 head tilt 0.0723770237000501 0.212058711959805 0.585950336933444 0.666666666666667 12.4 12 4 abnormal type II pneumocyte morphology 0.112888800720144 0.281514678487578 0.585950336933444 0.666666666666667 12.4 12 4 decreased susceptibility to pharmacologically induced seizures 0.112888800720144 0.281514678487578 0.585950336933444 0.666666666666667 12.4 12 4 abnormal foregut morphology 0.131832680674505 0.320575716737437 0.585950336933444 0.666666666666667 12.4 12 4 curly vibrissae 0.131832680674505 0.320575716737437 0.585950336933444 0.666666666666667 12.4 12 4 abnormal startle reflex 0.131832680674505 0.320575716737437 0.585950336933444 0.666666666666667 12.4 12 4 abnormal anxiety-related response 0.154705705553517 0.332179924526865 0.585950336933444 0.666666666666667 12.4 12 4 decreased cochlear outer hair cell number 0.154705705553517 0.332179924526865 0.585950336933444 0.666666666666667 12.4 12 4 increased bone ossification 0.154705705553517 0.332179924526865 0.585950336933444 0.666666666666667 12.4 12 4 right pulmonary isomerism 0.18268013120988 0.385099005410658 0.585950336933444 0.666666666666667 12.4 12 4 abnormal white adipose tissue morphology 0.18268013120988 0.385099005410658 0.585950336933444 0.666666666666667 12.4 12 4 abnormal anterior eye segment morphology 0.18268013120988 0.385099005410658 0.585950336933444 0.666666666666667 12.4 12 4 abnormal metanephric mesenchyme morphology 0.18268013120988 0.385099005410658 0.585950336933444 0.666666666666667 12.4 12 4 decreased fluid intake 0.18268013120988 0.385099005410658 0.585950336933444 0.666666666666667 12.4 12 4 decreased digestive secretion 0.261995956507665 0.479308773558192 0.585950336933444 0.666666666666667 12.4 12 4 small thyroid gland 0.261995956507665 0.479308773558192 0.585950336933444 0.666666666666667 12.4 12 4 absent tail 0.261995956507665 0.479308773558192 0.585950336933444 0.666666666666667 12.4 12 4 delayed somite formation 0.261995956507665 0.479308773558192 0.585950336933444 0.666666666666667 12.4 12 4 abnormal rostral-caudal body axis extension 0.261995956507665 0.479308773558192 0.585950336933444 0.666666666666667 12.4 12 4 stria vascularis degeneration 0.261995956507665 0.479308773558192 0.585950336933444 0.666666666666667 12.4 12 4 absent cochlear hair cells 0.261995956507665 0.479308773558192 0.585950336933444 0.666666666666667 12.4 12 4 hemoperitoneum 0.261995956507665 0.479308773558192 0.585950336933444 0.666666666666667 12.4 12 4 decreased renal glomerular filtration rate 0.261995956507665 0.479308773558192 0.585950336933444 0.666666666666667 12.4 12 4 hydrometra 0.261995956507665 0.479308773558192 0.585950336933444 0.666666666666667 12.4 12 4 abnormal behavioral response to addictive substance 0.261995956507665 0.479308773558192 0.585950336933444 0.666666666666667 12.4 12 4 synostosis 0.321199876075174 0.534616722473734 0.585950336933444 0.666666666666667 12.4 12 4 absent parathyroid glands 0.321199876075174 0.534616722473734 0.585950336933444 0.666666666666667 12.4 12 4 abnormal cholinergic neuron morphology 0.321199876075174 0.534616722473734 0.585950336933444 0.666666666666667 12.4 12 4 abnormal vagina epithelium morphology 0.321199876075174 0.534616722473734 0.585950336933444 0.666666666666667 12.4 12 4 wavy vibrissae 0.321199876075174 0.534616722473734 0.585950336933444 0.666666666666667 12.4 12 4 abnormal vomeronasal organ morphology 0.321199876075174 0.534616722473734 0.585950336933444 0.666666666666667 12.4 12 4 polycythemia 0.321199876075174 0.534616722473734 0.585950336933444 0.666666666666667 12.4 12 4 enlarged otoliths 0.321199876075174 0.534616722473734 0.585950336933444 0.666666666666667 12.4 12 4 biliary cyst 0.321199876075174 0.534616722473734 0.585950336933444 0.666666666666667 12.4 12 4 pancreas cysts 0.321199876075174 0.534616722473734 0.585950336933444 0.666666666666667 12.4 12 4 premature neuronal precursor differentiation 0.321199876075174 0.534616722473734 0.585950336933444 0.666666666666667 12.4 12 4 decreased cellular sensitivity to ionizing radiation 0.321199876075174 0.534616722473734 0.585950336933444 0.666666666666667 12.4 12 4 decreased muscle weight 0.321199876075174 0.534616722473734 0.585950336933444 0.666666666666667 12.4 12 4 decreased vestibular hair cell number 0.321199876075174 0.534616722473734 0.585950336933444 0.666666666666667 12.4 12 4 abnormal gallbladder physiology 0.321199876075174 0.534616722473734 0.585950336933444 0.666666666666667 12.4 12 4 increased stomach mucosa thickness 0.321199876075174 0.534616722473734 0.585950336933444 0.666666666666667 12.4 12 4 hemothorax 0.321199876075174 0.534616722473734 0.585950336933444 0.666666666666667 12.4 12 4 abnormal retinal development 0.321199876075174 0.534616722473734 0.585950336933444 0.666666666666667 12.4 12 4 abnormal hyoid bone lesser horn morphology 0.321199876075174 0.534616722473734 0.585950336933444 0.666666666666667 12.4 12 4 abnormal cerebellar layer morphology 0.321199876075174 0.534616722473734 0.585950336933444 0.666666666666667 12.4 12 4 abnormal incisor color 0.321199876075174 0.534616722473734 0.585950336933444 0.666666666666667 12.4 12 4 retropulsion 0.321199876075174 0.534616722473734 0.585950336933444 0.666666666666667 12.4 12 4 iris coloboma 0.321199876075174 0.534616722473734 0.585950336933444 0.666666666666667 12.4 12 4 fusion of atlas and occipital bones 0.321199876075174 0.534616722473734 0.585950336933444 0.666666666666667 12.4 12 4 abnormal heart left ventricle pressure 0.321199876075174 0.534616722473734 0.585950336933444 0.666666666666667 12.4 12 4 abnormal pulmonary alveolar parenchyma morphology 0.321199876075174 0.534616722473734 0.585950336933444 0.666666666666667 12.4 12 4 decreased airway resistance 0.321199876075174 0.534616722473734 0.585950336933444 0.666666666666667 12.4 12 4 abnormal lung lobe morphology 0.321199876075174 0.534616722473734 0.585950336933444 0.666666666666667 12.4 12 4 abnormal ureteric bud invasion 0.321199876075174 0.534616722473734 0.585950336933444 0.666666666666667 12.4 12 4 decreased bone mineral density of femur 0.321199876075174 0.534616722473734 0.585950336933444 0.666666666666667 12.4 12 4 increased endoplasmic reticulum stress 0.321199876075174 0.534616722473734 0.585950336933444 0.666666666666667 12.4 12 4 decreased systemic arterial blood pressure 0.0836955554529473 0.220776982173071 0.585950336933444 0.666666666666667 12.4 12 4 cardiovascular system phenotype 0.0836955554529473 0.220776982173071 0.585950336933444 0.666666666666667 12.4 12 4 abnormal hair cycle 0.0970459214919368 0.246328295623666 0.585950336933444 0.666666666666667 12.4 12 4 abnormal pain threshold 0.0970459214919368 0.246328295623666 0.585950336933444 0.666666666666667 12.4 12 4 decreased chondrocyte number 0.217505727691257 0.443479916091805 0.585950336933444 0.666666666666667 12.4 12 4 abnormal epidermis stratum spinosum morphology 0.217505727691257 0.443479916091805 0.585950336933444 0.666666666666667 12.4 12 4 altered righting response 0.217505727691257 0.443479916091805 0.585950336933444 0.666666666666667 12.4 12 4 abnormal microglial cell activation 0.217505727691257 0.443479916091805 0.585950336933444 0.666666666666667 12.4 12 4 abnormal branching involved in lung morphogenesis 0.217505727691257 0.443479916091805 0.585950336933444 0.666666666666667 12.4 12 4 abnormal pancreatic islet morphology 0.0404639743386602 0.134925115505921 0.580422503566147 0.660377358490566 12.4 12 4 abnormal axon extension 0.0463725511420046 0.146664616612507 0.58009083356411 0.66 12.4 12 4 impaired fertilization 0.0231995681346864 0.0848660672574006 0.577579617834395 0.657142857142857 12.4 12 4 abnormal crypts of Lieberkuhn morphology 0.108755670306739 0.273120842258614 0.576794862918859 0.65625 12.4 12 4 kidney cortex cysts 0.108755670306739 0.273120842258614 0.576794862918859 0.65625 12.4 12 4 enlarged epididymis 0.126410066051898 0.308128406961387 0.57584774491735 0.655172413793103 12.4 12 4 absent corpus luteum 0.0516195304203701 0.15479992851663 0.574682061223186 0.653846153846154 12.4 12 4 decreased urine osmolality 0.059198435319817 0.17603838357208 0.573992166791945 0.653061224489796 12.4 12 4 hypotension 0.1727809765451 0.365469965268653 0.573212286130543 0.652173913043478 12.4 12 4 pancreas inflammation 0.1727809765451 0.365469965268653 0.573212286130543 0.652173913043478 12.4 12 4 abnormal skin pigmentation 0.0900957390940798 0.229977579267854 0.571301578510108 0.65 12.4 12 4 absent placental labyrinth 0.203568174887964 0.41608532048793 0.571301578510108 0.65 12.4 12 4 abnormal heart right ventricle morphology 0.203568174887964 0.41608532048793 0.571301578510108 0.65 12.4 12 4 abnormal cued conditioning behavior 0.0653284949449145 0.191972393591819 0.568716503494225 0.647058823529412 12.4 12 4 abnormal vision 0.120366612842859 0.298665286231035 0.568716503494225 0.647058823529412 12.4 12 4 nephrocalcinosis 0.241555505378527 0.467784600723306 0.568716503494225 0.647058823529412 12.4 12 4 abnormal melanosome morphology 0.241555505378527 0.467784600723306 0.568716503494225 0.647058823529412 12.4 12 4 increased circulating magnesium level 0.241555505378527 0.467784600723306 0.568716503494225 0.647058823529412 12.4 12 4 delayed heart development 0.241555505378527 0.467784600723306 0.568716503494225 0.647058823529412 12.4 12 4 increased susceptibility to pharmacologically induced seizures 0.0159185418061848 0.0656672848140708 0.567639388904274 0.645833333333333 12.4 12 4 increased circulating corticosterone level 0.0860872186935115 0.221006271786043 0.566418659035663 0.644444444444444 12.4 12 4 abnormal metabolism 0.0860872186935115 0.221006271786043 0.566418659035663 0.644444444444444 12.4 12 4 abnormal vasoconstriction 0.28938452670184 0.487864459621028 0.565023539185821 0.642857142857143 12.4 12 4 abnormal kidney blood vessel morphology 0.28938452670184 0.487864459621028 0.565023539185821 0.642857142857143 12.4 12 4 abnormal placing response 0.28938452670184 0.487864459621028 0.565023539185821 0.642857142857143 12.4 12 4 abnormal endplate potential 0.28938452670184 0.487864459621028 0.565023539185821 0.642857142857143 12.4 12 4 abnormal decidualization 0.28938452670184 0.487864459621028 0.565023539185821 0.642857142857143 12.4 12 4 enlarged stomach 0.28938452670184 0.487864459621028 0.565023539185821 0.642857142857143 12.4 12 4 abnormal squamosal bone morphology 0.28938452670184 0.487864459621028 0.565023539185821 0.642857142857143 12.4 12 4 increased circulating growth hormone level 0.28938452670184 0.487864459621028 0.565023539185821 0.642857142857143 12.4 12 4 decreased tongue size 0.28938452670184 0.487864459621028 0.565023539185821 0.642857142857143 12.4 12 4 abnormal respiratory motile cilium physiology 0.28938452670184 0.487864459621028 0.565023539185821 0.642857142857143 12.4 12 4 impaired conditioned place preference behavior 0.189941412828333 0.390554605621436 0.562512323456106 0.64 12.4 12 4 abnormal reflex 0.131838777174834 0.320575716737437 0.561535739561217 0.638888888888889 12.4 12 4 narrow eye opening 0.131838777174834 0.320575716737437 0.561535739561217 0.638888888888889 12.4 12 4 decreased cardiac output 0.222963345387654 0.447119890864412 0.559316230709197 0.636363636363636 12.4 12 4 decreased circulating estradiol level 0.222963345387654 0.447119890864412 0.559316230709197 0.636363636363636 12.4 12 4 enlarged cranium 0.351414103789522 0.574036007265312 0.559316230709197 0.636363636363636 12.4 12 4 social withdrawal 0.351414103789522 0.574036007265312 0.559316230709197 0.636363636363636 12.4 12 4 abnormal primary sex determination 0.351414103789522 0.574036007265312 0.559316230709197 0.636363636363636 12.4 12 4 abnormal bronchiole morphology 0.351414103789522 0.574036007265312 0.559316230709197 0.636363636363636 12.4 12 4 fatigue 0.351414103789522 0.574036007265312 0.559316230709197 0.636363636363636 12.4 12 4 patent ductus arteriosus 0.351414103789522 0.574036007265312 0.559316230709197 0.636363636363636 12.4 12 4 impaired luteinization 0.351414103789522 0.574036007265312 0.559316230709197 0.636363636363636 12.4 12 4 abnormal pituitary gland development 0.351414103789522 0.574036007265312 0.559316230709197 0.636363636363636 12.4 12 4 enlarged placenta 0.351414103789522 0.574036007265312 0.559316230709197 0.636363636363636 12.4 12 4 abnormal platelet aggregation 0.351414103789522 0.574036007265312 0.559316230709197 0.636363636363636 12.4 12 4 abnormal extraembryonic ectoderm morphology 0.351414103789522 0.574036007265312 0.559316230709197 0.636363636363636 12.4 12 4 abnormal pulmonary alveolar sac morphology 0.351414103789522 0.574036007265312 0.559316230709197 0.636363636363636 12.4 12 4 chylous ascites 0.351414103789522 0.574036007265312 0.559316230709197 0.636363636363636 12.4 12 4 dextrocardia 0.152610871300874 0.328248631526956 0.559316230709197 0.636363636363636 12.4 12 4 abnormal hair growth 0.0891388017507014 0.227651713916704 0.557779647657798 0.634615384615385 12.4 12 4 abnormal nail morphology 0.263248469417965 0.479308773558192 0.555110845515894 0.631578947368421 12.4 12 4 enlarged adrenal glands 0.263248469417965 0.479308773558192 0.555110845515894 0.631578947368421 12.4 12 4 thin dermal layer 0.263248469417965 0.479308773558192 0.555110845515894 0.631578947368421 12.4 12 4 abnormal cochlear inner hair cell morphology 0.263248469417965 0.479308773558192 0.555110845515894 0.631578947368421 12.4 12 4 thin interventricular septum 0.263248469417965 0.479308773558192 0.555110845515894 0.631578947368421 12.4 12 4 right-sided stomach 0.263248469417965 0.479308773558192 0.555110845515894 0.631578947368421 12.4 12 4 impaired behavioral response to xenobiotic 0.165242025465332 0.349820883697883 0.552467460537247 0.628571428571429 12.4 12 4 abnormal pancreatic beta cell morphology 0.154260092764743 0.331652533061624 0.549328440875104 0.625 12.4 12 4 decreased ovulation rate 0.241028136329426 0.467491219586313 0.549328440875104 0.625 12.4 12 4 increased pancreatic beta cell number 0.313138510060612 0.526839393828727 0.549328440875104 0.625 12.4 12 4 impaired behavioral response to addictive substance 0.313138510060612 0.526839393828727 0.549328440875104 0.625 12.4 12 4 decreased skeletal muscle weight 0.313138510060612 0.526839393828727 0.549328440875104 0.625 12.4 12 4 abnormal ear pigmentation 0.435715929846232 0.655832927063831 0.549328440875104 0.625 12.4 12 4 pointed snout 0.435715929846232 0.655832927063831 0.549328440875104 0.625 12.4 12 4 abnormal esophageal epithelium morphology 0.435715929846232 0.655832927063831 0.549328440875104 0.625 12.4 12 4 abnormal hypoglossal nerve morphology 0.435715929846232 0.655832927063831 0.549328440875104 0.625 12.4 12 4 absent skin pigmentation 0.435715929846232 0.655832927063831 0.549328440875104 0.625 12.4 12 4 absent eyelids 0.435715929846232 0.655832927063831 0.549328440875104 0.625 12.4 12 4 unidirectional circling 0.435715929846232 0.655832927063831 0.549328440875104 0.625 12.4 12 4 abnormal circulating calcium level 0.435715929846232 0.655832927063831 0.549328440875104 0.625 12.4 12 4 abnormal muscle precursor cell migration 0.435715929846232 0.655832927063831 0.549328440875104 0.625 12.4 12 4 early eyelid opening 0.435715929846232 0.655832927063831 0.549328440875104 0.625 12.4 12 4 abnormal umbilical artery morphology 0.435715929846232 0.655832927063831 0.549328440875104 0.625 12.4 12 4 abnormal platelet shape 0.435715929846232 0.655832927063831 0.549328440875104 0.625 12.4 12 4 hair follicle degeneration 0.435715929846232 0.655832927063831 0.549328440875104 0.625 12.4 12 4 abnormal thermosensation 0.435715929846232 0.655832927063831 0.549328440875104 0.625 12.4 12 4 abnormal forelimb zeugopod morphology 0.435715929846232 0.655832927063831 0.549328440875104 0.625 12.4 12 4 abnormal gastric gland morphology 0.435715929846232 0.655832927063831 0.549328440875104 0.625 12.4 12 4 small frontal bone 0.435715929846232 0.655832927063831 0.549328440875104 0.625 12.4 12 4 abnormal vestibular labyrinth morphology 0.435715929846232 0.655832927063831 0.549328440875104 0.625 12.4 12 4 abnormal optic choroid morphology 0.435715929846232 0.655832927063831 0.549328440875104 0.625 12.4 12 4 abnormal circulating corticosterone level 0.435715929846232 0.655832927063831 0.549328440875104 0.625 12.4 12 4 stomach epithelial hyperplasia 0.435715929846232 0.655832927063831 0.549328440875104 0.625 12.4 12 4 choroidal neovascularization 0.435715929846232 0.655832927063831 0.549328440875104 0.625 12.4 12 4 hypergranulosis 0.435715929846232 0.655832927063831 0.549328440875104 0.625 12.4 12 4 abnormal olfactory bulb glomerular layer morphology 0.435715929846232 0.655832927063831 0.549328440875104 0.625 12.4 12 4 abnormal visual evoked potential 0.435715929846232 0.655832927063831 0.549328440875104 0.625 12.4 12 4 abnormal stomach position or orientation 0.435715929846232 0.655832927063831 0.549328440875104 0.625 12.4 12 4 absent ureteric bud 0.435715929846232 0.655832927063831 0.549328440875104 0.625 12.4 12 4 decreased surfactant secretion 0.435715929846232 0.655832927063831 0.549328440875104 0.625 12.4 12 4 increased mammary gland apoptosis 0.435715929846232 0.655832927063831 0.549328440875104 0.625 12.4 12 4 increased white adipose tissue amount 0.177546039651251 0.375070720706996 0.546359097951455 0.621621621621622 12.4 12 4 abnormal pancreatic beta cell physiology 0.177546039651251 0.375070720706996 0.546359097951455 0.621621621621622 12.4 12 4 stomach inflammation 0.221722509248647 0.447119890864412 0.545539968869069 0.620689655172414 12.4 12 4 hypoalgesia 0.282969687556441 0.479308773558192 0.544096741438198 0.619047619047619 12.4 12 4 abnormal bile salt homeostasis 0.282969687556441 0.479308773558192 0.544096741438198 0.619047619047619 12.4 12 4 small seminal vesicle 0.257908350788134 0.479308773558192 0.54087723409241 0.615384615384615 12.4 12 4 absent trabeculae carneae 0.376208180296976 0.59398149697793 0.54087723409241 0.615384615384615 12.4 12 4 small trigeminal ganglion 0.376208180296976 0.59398149697793 0.54087723409241 0.615384615384615 12.4 12 4 excessive scratching 0.376208180296976 0.59398149697793 0.54087723409241 0.615384615384615 12.4 12 4 abnormal bile duct development 0.376208180296976 0.59398149697793 0.54087723409241 0.615384615384615 12.4 12 4 abnormal GABAergic neuron morphology 0.376208180296976 0.59398149697793 0.54087723409241 0.615384615384615 12.4 12 4 abnormal afterhyperpolarization 0.376208180296976 0.59398149697793 0.54087723409241 0.615384615384615 12.4 12 4 abnormal insulin secretion 0.376208180296976 0.59398149697793 0.54087723409241 0.615384615384615 12.4 12 4 abnormal hair follicle inner root sheath morphology 0.376208180296976 0.59398149697793 0.54087723409241 0.615384615384615 12.4 12 4 abnormal circadian rhythm 0.175879790735736 0.371866535873476 0.539340651041011 0.613636363636364 12.4 12 4 decreased heart rate variability 0.334073950500688 0.555672986874264 0.53712114218899 0.611111111111111 12.4 12 4 primary atelectasis 0.334073950500688 0.555672986874264 0.53712114218899 0.611111111111111 12.4 12 4 fragile skeleton 0.301024808031626 0.506973060242837 0.53499813372184 0.608695652173913 12.4 12 4 abnormal retinal cone cell morphology 0.301024808031626 0.506973060242837 0.53499813372184 0.608695652173913 12.4 12 4 abnormal hepatocyte physiology 0.301024808031626 0.506973060242837 0.53499813372184 0.608695652173913 12.4 12 4 abnormal stomach mucosa morphology 0.317658221581064 0.534262898027652 0.5273553032401 0.6 12.4 12 4 waved hair 0.352768911212967 0.574036007265312 0.5273553032401 0.6 12.4 12 4 absent palatine bone horizontal plate 0.458330444666566 0.655832927063831 0.5273553032401 0.6 12.4 12 4 small petrosal ganglion 0.458330444666566 0.655832927063831 0.5273553032401 0.6 12.4 12 4 decreased circulating parathyroid hormone level 0.458330444666566 0.655832927063831 0.5273553032401 0.6 12.4 12 4 primary sex reversal 0.458330444666566 0.655832927063831 0.5273553032401 0.6 12.4 12 4 abnormal bone healing 0.458330444666566 0.655832927063831 0.5273553032401 0.6 12.4 12 4 delayed dark adaptation 0.458330444666566 0.655832927063831 0.5273553032401 0.6 12.4 12 4 intestinal hypoperistalsis 0.458330444666566 0.655832927063831 0.5273553032401 0.6 12.4 12 4 abnormal hypaxial muscle morphology 0.458330444666566 0.655832927063831 0.5273553032401 0.6 12.4 12 4 lymphedema 0.458330444666566 0.655832927063831 0.5273553032401 0.6 12.4 12 4 abnormal pillar cell morphology 0.458330444666566 0.655832927063831 0.5273553032401 0.6 12.4 12 4 ventricular premature beat 0.458330444666566 0.655832927063831 0.5273553032401 0.6 12.4 12 4 umbilical hernia 0.458330444666566 0.655832927063831 0.5273553032401 0.6 12.4 12 4 common ventricle 0.458330444666566 0.655832927063831 0.5273553032401 0.6 12.4 12 4 abnormal circadian temperature homeostasis 0.458330444666566 0.655832927063831 0.5273553032401 0.6 12.4 12 4 hyperpigmentation 0.397202725217714 0.625738935388895 0.5273553032401 0.6 12.4 12 4 abnormal respiratory system morphology 0.397202725217714 0.625738935388895 0.5273553032401 0.6 12.4 12 4 abnormal bronchus morphology 0.397202725217714 0.625738935388895 0.5273553032401 0.6 12.4 12 4 dilated ureter 0.397202725217714 0.625738935388895 0.5273553032401 0.6 12.4 12 4 decreased aggression towards males 0.397202725217714 0.625738935388895 0.5273553032401 0.6 12.4 12 4 abnormal rostral migratory stream morphology 0.397202725217714 0.625738935388895 0.5273553032401 0.6 12.4 12 4 abnormal Muller cell morphology 0.397202725217714 0.625738935388895 0.5273553032401 0.6 12.4 12 4 increased percent body fat/body weight 0.21653103902777 0.442399145446881 0.523974820527022 0.596153846153846 12.4 12 4 increased systemic arterial blood pressure 0.234220711818655 0.454464914702733 0.523615194706482 0.595744680851064 12.4 12 4 abnormal photoreceptor outer segment morphology 0.265387751505185 0.479308773558192 0.519365071372825 0.590909090909091 12.4 12 4 increased coping response 0.369645515133577 0.585105452685188 0.519365071372825 0.590909090909091 12.4 12 4 abnormal tracheal cartilage morphology 0.369645515133577 0.585105452685188 0.519365071372825 0.590909090909091 12.4 12 4 abnormal channel response 0.369645515133577 0.585105452685188 0.519365071372825 0.590909090909091 12.4 12 4 abnormal lens fiber morphology 0.288912105031601 0.487864459621028 0.518340682671893 0.58974358974359 12.4 12 4 hydroureter 0.415399945320733 0.639422873753295 0.517015003176568 0.588235294117647 12.4 12 4 abnormal urinary bladder morphology 0.415399945320733 0.639422873753295 0.517015003176568 0.588235294117647 12.4 12 4 enlarged sebaceous gland 0.415399945320733 0.639422873753295 0.517015003176568 0.588235294117647 12.4 12 4 abnormal heart rate 0.415399945320733 0.639422873753295 0.517015003176568 0.588235294117647 12.4 12 4 decreased growth hormone level 0.415399945320733 0.639422873753295 0.517015003176568 0.588235294117647 12.4 12 4 abnormal tendon morphology 0.415399945320733 0.639422873753295 0.517015003176568 0.588235294117647 12.4 12 4 abnormal survival 0.415399945320733 0.639422873753295 0.517015003176568 0.588235294117647 12.4 12 4 abnormal electroretinogram waveform feature 0.415399945320733 0.639422873753295 0.517015003176568 0.588235294117647 12.4 12 4 abnormal mineral level 0.476599509984123 0.655832927063831 0.512706544816764 0.583333333333333 12.4 12 4 abnormal esophagus morphology 0.476599509984123 0.655832927063831 0.512706544816764 0.583333333333333 12.4 12 4 mesocardia 0.476599509984123 0.655832927063831 0.512706544816764 0.583333333333333 12.4 12 4 abnormal pilomotor reflex 0.476599509984123 0.655832927063831 0.512706544816764 0.583333333333333 12.4 12 4 abnormal tracheal ciliated epithelium morphology 0.476599509984123 0.655832927063831 0.512706544816764 0.583333333333333 12.4 12 4 increased urine phosphate level 0.476599509984123 0.655832927063831 0.512706544816764 0.583333333333333 12.4 12 4 increased fear-related response 0.476599509984123 0.655832927063831 0.512706544816764 0.583333333333333 12.4 12 4 decreased left ventricle systolic pressure 0.476599509984123 0.655832927063831 0.512706544816764 0.583333333333333 12.4 12 4 abnormal anogenital distance 0.476599509984123 0.655832927063831 0.512706544816764 0.583333333333333 12.4 12 4 abnormal amacrine cell morphology 0.476599509984123 0.655832927063831 0.512706544816764 0.583333333333333 12.4 12 4 abnormal patella morphology 0.476599509984123 0.655832927063831 0.512706544816764 0.583333333333333 12.4 12 4 decreased oligodendrocyte number 0.476599509984123 0.655832927063831 0.512706544816764 0.583333333333333 12.4 12 4 increased type II pneumocyte number 0.476599509984123 0.655832927063831 0.512706544816764 0.583333333333333 12.4 12 4 flaky skin 0.431458986989431 0.655832927063831 0.50885160838957 0.578947368421053 12.4 12 4 decreased grooming behavior 0.431458986989431 0.655832927063831 0.50885160838957 0.578947368421053 12.4 12 4 maternal imprinting 0.431458986989431 0.655832927063831 0.50885160838957 0.578947368421053 12.4 12 4 abnormal photoreceptor inner segment morphology 0.431458986989431 0.655832927063831 0.50885160838957 0.578947368421053 12.4 12 4 abnormal behavioral response to xenobiotic 0.431458986989431 0.655832927063831 0.50885160838957 0.578947368421053 12.4 12 4 abnormal tectorial membrane morphology 0.399135318116879 0.626384245199626 0.507072406961634 0.576923076923077 12.4 12 4 abnormal zigzag hair morphology 0.491973051757157 0.655832927063831 0.502243145942952 0.571428571428571 12.4 12 4 abnormal prepulse inhibition 0.491973051757157 0.655832927063831 0.502243145942952 0.571428571428571 12.4 12 4 abnormal imprinting 0.491973051757157 0.655832927063831 0.502243145942952 0.571428571428571 12.4 12 4 abnormal hair cuticle 0.491973051757157 0.655832927063831 0.502243145942952 0.571428571428571 12.4 12 4 skeletal muscle necrosis 0.491973051757157 0.655832927063831 0.502243145942952 0.571428571428571 12.4 12 4 abnormal iris pigmentation 0.491973051757157 0.655832927063831 0.502243145942952 0.571428571428571 12.4 12 4 increased kidney weight 0.352746495554476 0.574036007265312 0.499781169737349 0.568627450980392 12.4 12 4 abnormal estrous cycle 0.424306450309534 0.652930587779131 0.498057786393427 0.566666666666667 12.4 12 4 blistering 0.458852434366113 0.655832927063831 0.496783981313137 0.565217391304348 12.4 12 4 abnormal epididymis epithelium morphology 0.505285287562561 0.655832927063831 0.494395596787593 0.5625 12.4 12 4 decreased circulating growth hormone level 0.505285287562561 0.655832927063831 0.494395596787593 0.5625 12.4 12 4 abnormal fertilization 0.505285287562561 0.655832927063831 0.494395596787593 0.5625 12.4 12 4 decreased circulating triiodothyronine level 0.505285287562561 0.655832927063831 0.494395596787593 0.5625 12.4 12 4 abnormal head movements 0.578860997060054 0.67681162405964 0.488291947444537 0.555555555555556 12.4 12 4 deformed nails 0.578860997060054 0.67681162405964 0.488291947444537 0.555555555555556 12.4 12 4 absent enteric neurons 0.578860997060054 0.67681162405964 0.488291947444537 0.555555555555556 12.4 12 4 small geniculate ganglion 0.578860997060054 0.67681162405964 0.488291947444537 0.555555555555556 12.4 12 4 small nodose ganglion 0.578860997060054 0.67681162405964 0.488291947444537 0.555555555555556 12.4 12 4 abnormal ion homeostasis 0.578860997060054 0.67681162405964 0.488291947444537 0.555555555555556 12.4 12 4 abnormal taste sensitivity 0.578860997060054 0.67681162405964 0.488291947444537 0.555555555555556 12.4 12 4 long gestation period 0.578860997060054 0.67681162405964 0.488291947444537 0.555555555555556 12.4 12 4 yellow coat color 0.578860997060054 0.67681162405964 0.488291947444537 0.555555555555556 12.4 12 4 abnormal bony labyrinth 0.578860997060054 0.67681162405964 0.488291947444537 0.555555555555556 12.4 12 4 small scapula 0.578860997060054 0.67681162405964 0.488291947444537 0.555555555555556 12.4 12 4 abnormal hair cell mechanoelectric transduction 0.578860997060054 0.67681162405964 0.488291947444537 0.555555555555556 12.4 12 4 multiflagellated sperm 0.578860997060054 0.67681162405964 0.488291947444537 0.555555555555556 12.4 12 4 abnormal pulmonary alveolar system morphology 0.578860997060054 0.67681162405964 0.488291947444537 0.555555555555556 12.4 12 4 decreased pancreatic beta cell proliferation 0.578860997060054 0.67681162405964 0.488291947444537 0.555555555555556 12.4 12 4 decreased skin tensile strength 0.527635746271777 0.655832927063831 0.483409027970091 0.55 12.4 12 4 abnormal male reproductive system physiology 0.527635746271777 0.655832927063831 0.483409027970091 0.55 12.4 12 4 abnormal circulating cytokine level 0.527635746271777 0.655832927063831 0.483409027970091 0.55 12.4 12 4 increased mast cell number 0.58663005371902 0.683966373858009 0.479413912036454 0.545454545454545 12.4 12 4 allodynia 0.58663005371902 0.683966373858009 0.479413912036454 0.545454545454545 12.4 12 4 abnormal frequency of paradoxical sleep 0.58663005371902 0.683966373858009 0.479413912036454 0.545454545454545 12.4 12 4 abnormal nerve fiber response 0.58663005371902 0.683966373858009 0.479413912036454 0.545454545454545 12.4 12 4 abnormal lymph circulation 0.58663005371902 0.683966373858009 0.479413912036454 0.545454545454545 12.4 12 4 increased motor neuron number 0.58663005371902 0.683966373858009 0.479413912036454 0.545454545454545 12.4 12 4 decreased palatine bone horizontal plate size 0.58663005371902 0.683966373858009 0.479413912036454 0.545454545454545 12.4 12 4 shortened PR interval 0.58663005371902 0.683966373858009 0.479413912036454 0.545454545454545 12.4 12 4 increased pancreatic beta cell proliferation 0.58663005371902 0.683966373858009 0.479413912036454 0.545454545454545 12.4 12 4 abnormal phrenic nerve innervation pattern to diaphragm 0.58663005371902 0.683966373858009 0.479413912036454 0.545454545454545 12.4 12 4 decreased colon length 0.58663005371902 0.683966373858009 0.479413912036454 0.545454545454545 12.4 12 4 abnormal sympathetic ganglion morphology 0.593722727952461 0.691263882884038 0.473267579830859 0.538461538461538 12.4 12 4 abnormal intercostal muscle morphology 0.593722727952461 0.691263882884038 0.473267579830859 0.538461538461538 12.4 12 4 decreased alcohol consumption 0.593722727952461 0.691263882884038 0.473267579830859 0.538461538461538 12.4 12 4 decreased luteinizing hormone level 0.593722727952461 0.691263882884038 0.473267579830859 0.538461538461538 12.4 12 4 increased renin activity 0.593722727952461 0.691263882884038 0.473267579830859 0.538461538461538 12.4 12 4 abnormal gut flora balance 0.593722727952461 0.691263882884038 0.473267579830859 0.538461538461538 12.4 12 4 no suckling reflex 0.600281996373663 0.698573785253561 0.468760269546755 0.533333333333333 12.4 12 4 greasy coat 0.600281996373663 0.698573785253561 0.468760269546755 0.533333333333333 12.4 12 4 decreased pancreatic beta cell number 0.582323913689337 0.680700533506685 0.465313502858911 0.529411764705882 12.4 12 4 distended urinary bladder 0.606406297584618 0.705370897938619 0.465313502858911 0.529411764705882 12.4 12 4 common atrium 0.606406297584618 0.705370897938619 0.465313502858911 0.529411764705882 12.4 12 4 increased urine calcium level 0.696697913322816 0.808319057551542 0.439462752700083 0.5 12.4 12 4 nuclear cataracts 0.696697913322816 0.808319057551542 0.439462752700083 0.5 12.4 12 4 absent maxillary shelf 0.699391549453541 0.809933184015681 0.439462752700083 0.5 12.4 12 4 abnormal optic nerve innervation 0.699391549453541 0.809933184015681 0.439462752700083 0.5 12.4 12 4 alcohol preference 0.699391549453541 0.809933184015681 0.439462752700083 0.5 12.4 12 4 rickets 0.699391549453541 0.809933184015681 0.439462752700083 0.5 12.4 12 4 increased left ventricle diastolic pressure 0.699391549453541 0.809933184015681 0.439462752700083 0.5 12.4 12 4 increased defecation amount 0.699391549453541 0.809933184015681 0.439462752700083 0.5 12.4 12 4 abnormal sperm principal piece morphology 0.699391549453541 0.809933184015681 0.439462752700083 0.5 12.4 12 4 abnormal retinal blood vessel pattern 0.699391549453541 0.809933184015681 0.439462752700083 0.5 12.4 12 4 abnormal pinna reflex 0.695472404147766 0.807650609391955 0.439462752700083 0.5 12.4 12 4 decreased vascular permeability 0.695472404147766 0.807650609391955 0.439462752700083 0.5 12.4 12 4 abnormal uterus development 0.695472404147766 0.807650609391955 0.439462752700083 0.5 12.4 12 4 abnormal pancreas development 0.695472404147766 0.807650609391955 0.439462752700083 0.5 12.4 12 4 decreased circulating prolactin level 0.695278705184765 0.807650609391955 0.439462752700083 0.5 12.4 12 4 abnormal pancreatic alpha cell morphology 0.695278705184765 0.807650609391955 0.439462752700083 0.5 12.4 12 4 abnormal urinary bladder physiology 0.695278705184765 0.807650609391955 0.439462752700083 0.5 12.4 12 4 ear inflammation 0.696660597453916 0.808319057551542 0.439462752700083 0.5 12.4 12 4 increased placenta weight 0.696660597453916 0.808319057551542 0.439462752700083 0.5 12.4 12 4 abnormal ocular fundus morphology 0.701179213118727 0.811814425242185 0.439462752700083 0.5 12.4 12 4 decreased circulating progesterone level 0.702999791057687 0.813732889835271 0.439462752700083 0.5 12.4 12 4 decreased retinal photoreceptor cell number 0.764574129920853 0.851536378446799 0.424308864675942 0.482758620689655 12.4 12 4 dystrophic cardiac calcinosis 0.784893057026591 0.855387285587577 0.405657925569307 0.461538461538462 12.4 12 4 abnormal vestibular ganglion morphology 0.793359462565642 0.864424731989503 0.399511593363712 0.454545454545455 12.4 12 4 abnormal stomach glandular epithelium morphology 0.837093396434052 0.908494687447516 0.390633557955629 0.444444444444444 12.4 12 4 increased circulating estradiol level 0.843697026545371 0.915262256228352 0.384529908612573 0.4375 12.4 12 4 abnormal intestinal lipid absorption 0.843697026545371 0.915262256228352 0.384529908612573 0.4375 12.4 12 4 decreased chemically-elicited antinociception 0.885172484606467 0.954635402323255 0.370073897010596 0.421052631578947 12.4 12 4 impaired sperm capacitation 0.862430080502589 0.930713590130235 0.366218960583403 0.416666666666667 12.4 12 4 reduced cerebellar foliation 0.862430080502589 0.930713590130235 0.366218960583403 0.416666666666667 12.4 12 4 decreased compensatory feeding amount 0.862430080502589 0.930713590130235 0.366218960583403 0.416666666666667 12.4 12 4 increased susceptibility to age related obesity 0.941255158897548 1 0.343927371678326 0.391304347826087 12.4 12 4 abnormal pituitary gland morphology 0.934989630221224 0.994138365110192 0.329597064525062 0.375 12.4 12 4 abnormal single cell response 0.970164067839335 1 0.325527964963024 0.37037037037037 12.4 12 4 echinocytosis 0.000306383642487928 0.00648620689947847 2.85062429057889 1 13.1 13 1 abnormal mismatch repair 0.0011802642554853 0.0199044565119978 2.85062429057889 1 13.1 13 1 leptocytosis 0.0011802642554853 0.0199044565119978 2.85062429057889 1 13.1 13 1 increased renal carcinoma incidence 0.0011802642554853 0.0199044565119978 2.85062429057889 1 13.1 13 1 abnormal eyelid margin morphology 0.0011802642554853 0.0199044565119978 2.85062429057889 1 13.1 13 1 elevated level of mitotic sister chromatid exchange 0.000491730828157974 0.00978544348034368 2.49429625425653 0.875 13.1 13 1 binucleate 0.000491730828157974 0.00978544348034368 2.49429625425653 0.875 13.1 13 1 abnormal mitotic spindle assembly checkpoint 0.000491730828157974 0.00978544348034368 2.49429625425653 0.875 13.1 13 1 pleural effusion 0.000491730828157974 0.00978544348034368 2.49429625425653 0.875 13.1 13 1 macrocytosis 1.46984700223552e-06 6.47122905851477e-05 2.47054105183504 0.866666666666667 13.1 13 1 skin photosensitivity 0.001667522647873 0.0265045532689079 2.44339224906762 0.857142857142857 13.1 13 1 decreased tidal volume 0.001667522647873 0.0265045532689079 2.44339224906762 0.857142857142857 13.1 13 1 decreased DN2 thymocyte number 0.001667522647873 0.0265045532689079 2.44339224906762 0.857142857142857 13.1 13 1 decreased brain cholesterol level 0.001667522647873 0.0265045532689079 2.44339224906762 0.857142857142857 13.1 13 1 abnormal erythrocyte physiology 1.62848702770889e-08 1.1462752112754e-06 2.44339224906762 0.857142857142857 13.1 13 1 liver cirrhosis 0.00554966732047213 0.0646594728790371 2.37552024214907 0.833333333333333 13.1 13 1 abnormal blastocoele morphology 0.00554966732047213 0.0646594728790371 2.37552024214907 0.833333333333333 13.1 13 1 delayed chorioallantoic fusion 0.00554966732047213 0.0646594728790371 2.37552024214907 0.833333333333333 13.1 13 1 increased erythrocyte clearance 0.00554966732047213 0.0646594728790371 2.37552024214907 0.833333333333333 13.1 13 1 thymus cortex atrophy 0.00554966732047213 0.0646594728790371 2.37552024214907 0.833333333333333 13.1 13 1 additional anastomosis between intracranial vertebral arteries 0.00554966732047213 0.0646594728790371 2.37552024214907 0.833333333333333 13.1 13 1 increased mortality induced by gamma-irradiation 2.46217825119193e-10 2.55194516659997e-08 2.35913734392736 0.827586206896552 13.1 13 1 abnormal dorsal-ventral polarity of the somites 0.000173235827775106 0.00395343230817043 2.33232896501909 0.818181818181818 13.1 13 1 abnormal chromosome morphology 3.58485367402636e-12 4.57298641750798e-10 2.31131699236126 0.810810810810811 13.1 13 1 abnormal erythrocyte osmotic lysis 7.90471095217119e-09 5.95847530106844e-07 2.30242731162141 0.807692307692308 13.1 13 1 abnormal erythropoiesis 6.47087920078254e-31 4.59894628912759e-28 2.28049943246311 0.8 13.1 13 1 abnormal placenta size 1.87640973167211e-05 0.000579822261805513 2.28049943246311 0.8 13.1 13 1 abnormal trophectoderm morphology 1.87640973167211e-05 0.000579822261805513 2.28049943246311 0.8 13.1 13 1 acanthocytosis 0.000550340126190817 0.0106534713143942 2.28049943246311 0.8 13.1 13 1 hemolytic anemia 7.65923575887071e-08 4.59092745787732e-06 2.25674423004162 0.791666666666667 13.1 13 1 testis degeneration 5.82482132068948e-05 0.00154965166152033 2.23977622831198 0.785714285714286 13.1 13 1 absent inner cell mass 6.37678655494109e-06 0.000229217183595608 2.2171522260058 0.777777777777778 13.1 13 1 decreased level of surface class I molecules 0.00171259073861571 0.0268774098568238 2.2171522260058 0.777777777777778 13.1 13 1 polycythemia 0.00171259073861571 0.0268774098568238 2.2171522260058 0.777777777777778 13.1 13 1 abnormal telomere morphology 0.00171259073861571 0.0268774098568238 2.2171522260058 0.777777777777778 13.1 13 1 inner cell mass degeneration 3.08246121367662e-09 2.55587408967353e-07 2.20693493464172 0.774193548387097 13.1 13 1 increased foot pad pigmentation 0.000177793424799376 0.00400236329582306 2.19278791582991 0.769230769230769 13.1 13 1 abnormal telomere length 0.000177793424799376 0.00400236329582306 2.19278791582991 0.769230769230769 13.1 13 1 absent hypoglossal nerve 0.000177793424799376 0.00400236329582306 2.19278791582991 0.769230769230769 13.1 13 1 increased erythroid progenitor cell number 3.65537808193918e-10 3.71132774645866e-08 2.15722919287051 0.756756756756757 13.1 13 1 increased fibroblast apoptosis 9.27373181470186e-09 6.78482584972673e-07 2.13796821793417 0.75 13.1 13 1 increased skin tumor incidence 6.3159707629212e-06 0.000229217183595608 2.13796821793417 0.75 13.1 13 1 decreased red blood cell distribution width 0.00053211484546946 0.0104635231470773 2.13796821793417 0.75 13.1 13 1 abnormal vitelline vein connection 0.00053211484546946 0.0104635231470773 2.13796821793417 0.75 13.1 13 1 schistocytosis 0.00519489810701809 0.0625777677540314 2.13796821793417 0.75 13.1 13 1 craniofacial phenotype 0.00519489810701809 0.0625777677540314 2.13796821793417 0.75 13.1 13 1 abnormal hepatic vein morphology 0.00519489810701809 0.0625777677540314 2.13796821793417 0.75 13.1 13 1 myocardial trabeculae hypoplasia 0.00519489810701809 0.0625777677540314 2.13796821793417 0.75 13.1 13 1 decreased cranium length 0.00519489810701809 0.0625777677540314 2.13796821793417 0.75 13.1 13 1 abnormal umbilical vein topology 0.00519489810701809 0.0625777677540314 2.13796821793417 0.75 13.1 13 1 increased brain apoptosis 0.00519489810701809 0.0625777677540314 2.13796821793417 0.75 13.1 13 1 abnormal cell nucleus morphology 4.94042327474548e-12 6.14465144796469e-10 2.12280532277151 0.74468085106383 13.1 13 1 embryonic lethality before implantation, incomplete penetrance 5.93123168497484e-06 0.000216969688476102 2.07318130223919 0.727272727272727 13.1 13 1 delayed hepatic development 0.00155595158863271 0.0252145249297972 2.07318130223919 0.727272727272727 13.1 13 1 abnormal hemoglobin 0.00155595158863271 0.0252145249297972 2.07318130223919 0.727272727272727 13.1 13 1 increased number of Howell-Jolly bodies 0.00155595158863271 0.0252145249297972 2.07318130223919 0.727272727272727 13.1 13 1 abnormal megakaryocyte differentiation 5.27169922376202e-05 0.0014331532042741 2.05878420986253 0.722222222222222 13.1 13 1 abnormal hypoglossal nerve topology 5.27169922376202e-05 0.0014331532042741 2.05878420986253 0.722222222222222 13.1 13 1 decreased mean corpuscular hemoglobin 2.41130730492451e-15 4.44305697851831e-13 2.05412632703479 0.720588235294118 13.1 13 1 increased cellular sensitivity to ionizing radiation 1.91620892560759e-06 8.01104151672082e-05 2.0524494892168 0.72 13.1 13 1 broad head 0.01525502900197 0.139985032943717 2.03616020755635 0.714285714285714 13.1 13 1 mammary gland hyperplasia 0.01525502900197 0.139985032943717 2.03616020755635 0.714285714285714 13.1 13 1 abnormal circulating alanine transaminase level 0.01525502900197 0.139985032943717 2.03616020755635 0.714285714285714 13.1 13 1 abnormal gastrulation movements 0.01525502900197 0.139985032943717 2.03616020755635 0.714285714285714 13.1 13 1 aorta coarctation 0.01525502900197 0.139985032943717 2.03616020755635 0.714285714285714 13.1 13 1 increased cell nucleus count 0.01525502900197 0.139985032943717 2.03616020755635 0.714285714285714 13.1 13 1 abnormal sperm annulus morphology 0.01525502900197 0.139985032943717 2.03616020755635 0.714285714285714 13.1 13 1 decreased DN4 thymocyte number 0.01525502900197 0.139985032943717 2.03616020755635 0.714285714285714 13.1 13 1 arteritis 0.01525502900197 0.139985032943717 2.03616020755635 0.714285714285714 13.1 13 1 embryonic lethality at implantation, incomplete penetrance 0.01525502900197 0.139985032943717 2.03616020755635 0.714285714285714 13.1 13 1 small tail bud 0.01525502900197 0.139985032943717 2.03616020755635 0.714285714285714 13.1 13 1 ductus venosus stenosis 0.01525502900197 0.139985032943717 2.03616020755635 0.714285714285714 13.1 13 1 abnormal Mullerian duct topology 0.01525502900197 0.139985032943717 2.03616020755635 0.714285714285714 13.1 13 1 embryo tumor 0.01525502900197 0.139985032943717 2.03616020755635 0.714285714285714 13.1 13 1 abnormal hematopoietic system physiology 1.67660660678527e-05 0.000527918852452957 2.03616020755635 0.714285714285714 13.1 13 1 embryonic lethality at implantation, complete penetrance 1.67660660678527e-05 0.000527918852452957 2.03616020755635 0.714285714285714 13.1 13 1 increased hepatoma incidence 0.000148232582386411 0.00347857121402073 2.0122053815851 0.705882352941177 13.1 13 1 abnormal cell cycle 2.21779610540398e-23 1.00304869312589e-20 2.00783102205991 0.704347826086957 13.1 13 1 abnormal embryonic erythrocyte morphology 0.00442450883427379 0.056263073018299 1.99543700340522 0.7 13.1 13 1 abnormal double-strand DNA break repair 2.26950149179317e-09 2.01620891458412e-07 1.98880764458992 0.697674418604651 13.1 13 1 abnormal tail bud morphology 0.00132933804197715 0.0221185844777134 1.97350912424692 0.692307692307692 13.1 13 1 empty decidua capsularis 0.00132933804197715 0.0221185844777134 1.97350912424692 0.692307692307692 13.1 13 1 polychromatophilia 1.5087157258441e-06 6.58408836497754e-05 1.96594778660613 0.689655172413793 13.1 13 1 abnormal embryonic hematopoiesis 4.85428748490464e-07 2.46429390177557e-05 1.95980419977299 0.6875 13.1 13 1 disorganized yolk sac vascular plexus 0.000408046634665752 0.00831980330927097 1.95980419977299 0.6875 13.1 13 1 increased intestinal adenocarcinoma incidence 0.000408046634665752 0.00831980330927097 1.95980419977299 0.6875 13.1 13 1 blepharitis 0.000408046634665752 0.00831980330927097 1.95980419977299 0.6875 13.1 13 1 abnormal blastocyst morphology 0.000127070749283193 0.00305399506127481 1.95042714618555 0.684210526315789 13.1 13 1 increased mammary gland tumor incidence 3.99835683168768e-05 0.0011238319343303 1.94360747084924 0.681818181818182 13.1 13 1 increased cellular sensitivity to gamma-irradiation 1.74371966974914e-09 1.57727370127309e-07 1.94085058081967 0.680851063829787 13.1 13 1 failure of blastocyst to hatch from the zona pellucida 4.04539212522502e-06 0.000152468377446928 1.93435219717853 0.678571428571429 13.1 13 1 abnormal mitotic spindle morphology 4.04539212522502e-06 0.000152468377446928 1.93435219717853 0.678571428571429 13.1 13 1 subcutaneous edema 4.04539212522502e-06 0.000152468377446928 1.93435219717853 0.678571428571429 13.1 13 1 pale liver 7.5739781676978e-14 1.21550133497731e-11 1.92609749363438 0.675675675675676 13.1 13 1 embryonic lethality before implantation, complete penetrance 4.82006778598613e-22 1.99831976960675e-19 1.91561952326901 0.672 13.1 13 1 increased hemangiosarcoma incidence 3.35747479677468e-05 0.000965516596182314 1.90041619371926 0.666666666666667 13.1 13 1 abnormal inner cell mass apoptosis 3.35747479677468e-05 0.000965516596182314 1.90041619371926 0.666666666666667 13.1 13 1 abnormal aerobic respiration 0.000339263762683993 0.00715185262437655 1.90041619371926 0.666666666666667 13.1 13 1 interstitial pneumonia 0.00360362507495921 0.0483235437949382 1.90041619371926 0.666666666666667 13.1 13 1 increased papilloma incidence 0.00360362507495921 0.0483235437949382 1.90041619371926 0.666666666666667 13.1 13 1 loss of dopaminergic neurons 0.00360362507495921 0.0483235437949382 1.90041619371926 0.666666666666667 13.1 13 1 increased osteosarcoma incidence 0.00360362507495921 0.0483235437949382 1.90041619371926 0.666666666666667 13.1 13 1 decreased mammary gland epithelial cell proliferation 0.00360362507495921 0.0483235437949382 1.90041619371926 0.666666666666667 13.1 13 1 prenatal growth retardation 0.00360362507495921 0.0483235437949382 1.90041619371926 0.666666666666667 13.1 13 1 heart hyperplasia 0.0121595128438228 0.119081843303186 1.90041619371926 0.666666666666667 13.1 13 1 decreased cellular sensitivity to ionizing radiation 0.0121595128438228 0.119081843303186 1.90041619371926 0.666666666666667 13.1 13 1 increased neuronal precursor cell number 0.0121595128438228 0.119081843303186 1.90041619371926 0.666666666666667 13.1 13 1 abnormal oxidative phosphorylation 0.0121595128438228 0.119081843303186 1.90041619371926 0.666666666666667 13.1 13 1 abnormal ductus venosus valve topology 0.0121595128438228 0.119081843303186 1.90041619371926 0.666666666666667 13.1 13 1 abnormal infrahyoid muscle connection 0.0121595128438228 0.119081843303186 1.90041619371926 0.666666666666667 13.1 13 1 increased cardiac muscle glycogen level 0.0121595128438228 0.119081843303186 1.90041619371926 0.666666666666667 13.1 13 1 absent segment of posterior cerebral artery 0.000106254808535868 0.00265637021339669 1.90041619371926 0.666666666666667 13.1 13 1 heterochrony 0.00109631029753199 0.0191373464218304 1.90041619371926 0.666666666666667 13.1 13 1 embryonic lethality between implantation and somite formation, complete penetrance 4.63770848611345e-39 4.61451994368288e-36 1.87326739095184 0.657142857142857 13.1 13 1 abnormal embryonic erythropoiesis 8.86507728404875e-06 0.000300025574749269 1.86765039727582 0.655172413793103 13.1 13 1 blood in lymph vessels 8.86507728404875e-06 0.000300025574749269 1.86765039727582 0.655172413793103 13.1 13 1 liver hypoplasia 2.77056301419843e-09 2.37647430959262e-07 1.86386972845543 0.653846153846154 13.1 13 1 increased thymocyte apoptosis 2.7736724589761e-05 0.000816510087775508 1.86386972845543 0.653846153846154 13.1 13 1 increased embryonic tissue cell apoptosis 3.11523817425229e-13 4.63119150716244e-11 1.86386972845543 0.653846153846154 13.1 13 1 increased tumor incidence 3.96995241546211e-20 1.09725073705133e-17 1.86210135110395 0.653225806451613 13.1 13 1 increased mammary adenocarcinoma incidence 0.000276524510869577 0.00590433236727959 1.85290578887628 0.65 13.1 13 1 abnormal sperm mitochondrial sheath morphology 0.000276524510869577 0.00590433236727959 1.85290578887628 0.65 13.1 13 1 absent ductus venosus valve 0.000276524510869577 0.00590433236727959 1.85290578887628 0.65 13.1 13 1 increased lung adenoma incidence 7.27068377706526e-06 0.000258368941363569 1.83911244553477 0.645161290322581 13.1 13 1 abnormal definitive hematopoiesis 6.47181837299477e-15 1.14990344305889e-12 1.83911244553477 0.645161290322581 13.1 13 1 decreased erythrocyte cell number 5.7956521834725e-24 2.88333696127757e-21 1.83384110413037 0.643312101910828 13.1 13 1 increased hemangioma incidence 0.00286416490073097 0.0405960694619276 1.83254418680071 0.642857142857143 13.1 13 1 failure of zygotic cell division 0.00286416490073097 0.0405960694619276 1.83254418680071 0.642857142857143 13.1 13 1 vascular smooth muscle hypoplasia 0.00286416490073097 0.0405960694619276 1.83254418680071 0.642857142857143 13.1 13 1 abnormal maternal decidual layer morphology 0.00286416490073097 0.0405960694619276 1.83254418680071 0.642857142857143 13.1 13 1 lysosomal protein accumulation 0.00286416490073097 0.0405960694619276 1.83254418680071 0.642857142857143 13.1 13 1 multiple persisting craniopharyngeal ducts 0.00286416490073097 0.0405960694619276 1.83254418680071 0.642857142857143 13.1 13 1 increased B cell derived lymphoma incidence 1.76816106661229e-08 1.22175018144391e-06 1.82439954597049 0.64 13.1 13 1 increased adenoma incidence 0.000222229478919103 0.00489199848505547 1.81403363945929 0.636363636363636 13.1 13 1 abnormal thrombopoiesis 0.00944448401414566 0.0999708680220737 1.81403363945929 0.636363636363636 13.1 13 1 abnormal food preference 0.00944448401414566 0.0999708680220737 1.81403363945929 0.636363636363636 13.1 13 1 increased T cell derived lymphoma incidence 4.39738576152191e-08 2.80474284148353e-06 1.80345618383562 0.63265306122449 13.1 13 1 increased liver adenoma incidence 0.000703023214228223 0.0130994025872113 1.80039428878667 0.631578947368421 13.1 13 1 increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 0.000703023214228223 0.0130994025872113 1.80039428878667 0.631578947368421 13.1 13 1 embryonic lethality between implantation and somite formation, incomplete penetrance 0.000703023214228223 0.0130994025872113 1.80039428878667 0.631578947368421 13.1 13 1 increased red blood cell distribution width 4.76035700476571e-06 0.000178065985704582 1.79182098264959 0.628571428571429 13.1 13 1 small pancreas 0.00224341640230906 0.0333164077656345 1.7816401816118 0.625 13.1 13 1 decreased fibroblast apoptosis 0.00224341640230906 0.0333164077656345 1.7816401816118 0.625 13.1 13 1 increased sensitivity to skin irradiation 0.0320219138268898 0.238486558815534 1.7816401816118 0.625 13.1 13 1 abnormal erythrocyte cell number 0.0320219138268898 0.238486558815534 1.7816401816118 0.625 13.1 13 1 preneoplasia 0.0320219138268898 0.238486558815534 1.7816401816118 0.625 13.1 13 1 colon polyps 0.0320219138268898 0.238486558815534 1.7816401816118 0.625 13.1 13 1 increased cardiac output 0.0320219138268898 0.238486558815534 1.7816401816118 0.625 13.1 13 1 abnormal platelet shape 0.0320219138268898 0.238486558815534 1.7816401816118 0.625 13.1 13 1 tau protein deposits 0.0320219138268898 0.238486558815534 1.7816401816118 0.625 13.1 13 1 abnormal kidney epithelium morphology 0.0320219138268898 0.238486558815534 1.7816401816118 0.625 13.1 13 1 accumulation of giant lysosomes in kidney/renal tubule cells 0.0320219138268898 0.238486558815534 1.7816401816118 0.625 13.1 13 1 abnormal NK cell morphology 0.0320219138268898 0.238486558815534 1.7816401816118 0.625 13.1 13 1 choroidal neovascularization 0.0320219138268898 0.238486558815534 1.7816401816118 0.625 13.1 13 1 abnormal meiotic spindle morphology 0.0320219138268898 0.238486558815534 1.7816401816118 0.625 13.1 13 1 abnormal base-excision repair 0.0320219138268898 0.238486558815534 1.7816401816118 0.625 13.1 13 1 abnormal cerebellum deep nucleus morphology 0.0320219138268898 0.238486558815534 1.7816401816118 0.625 13.1 13 1 increased cardiac stroke volume 0.0320219138268898 0.238486558815534 1.7816401816118 0.625 13.1 13 1 increased testis apoptosis 0.0320219138268898 0.238486558815534 1.7816401816118 0.625 13.1 13 1 absent hypoglossal canal 0.0320219138268898 0.238486558815534 1.7816401816118 0.625 13.1 13 1 embryo cyst 0.0320219138268898 0.238486558815534 1.7816401816118 0.625 13.1 13 1 abnormal respiratory electron transport chain 3.81198052289847e-06 0.000148160961729843 1.77200969414363 0.621621621621622 13.1 13 1 anemia 2.10764442144835e-28 1.31069137458819e-25 1.76981887234993 0.62085308056872 13.1 13 1 increased erythrocyte cell number 6.12865186856563e-09 4.76406922595531e-07 1.75788497919031 0.616666666666667 13.1 13 1 absent common myeloid progenitor cells 0.0072424843277305 0.0811517106541875 1.75423033266393 0.615384615384615 13.1 13 1 increased pituitary adenoma incidence 0.0072424843277305 0.0811517106541875 1.75423033266393 0.615384615384615 13.1 13 1 decreased blood urea nitrogen level 7.95521538226296e-07 3.80549966603444e-05 1.74924672376432 0.613636363636364 13.1 13 1 abnormal redox activity 0.00174097167995398 0.0269823492453927 1.74204817757599 0.611111111111111 13.1 13 1 decreased cellular sensitivity to gamma-irradiation 0.00174097167995398 0.0269823492453927 1.74204817757599 0.611111111111111 13.1 13 1 decreased tumor latency 0.00174097167995398 0.0269823492453927 1.74204817757599 0.611111111111111 13.1 13 1 increased effector memory CD8-positive, alpha-beta T cell number 0.00174097167995398 0.0269823492453927 1.74204817757599 0.611111111111111 13.1 13 1 abnormal cell death 6.31205714024239e-07 3.07867492869665e-05 1.73516261165671 0.608695652173913 13.1 13 1 failure to gastrulate 6.31205714024239e-07 3.07867492869665e-05 1.73516261165671 0.608695652173913 13.1 13 1 lymphoid hyperplasia 0.000109435907337952 0.00270867482092691 1.7307361764229 0.607142857142857 13.1 13 1 premature aging 0.000109435907337952 0.00270867482092691 1.7307361764229 0.607142857142857 13.1 13 1 decreased circulating total protein level 1.03889417044136e-07 6.00988197435554e-06 1.71037457434733 0.6 13.1 13 1 enlarged testis 0.0237620188581464 0.190671038418191 1.71037457434733 0.6 13.1 13 1 decreased incidence of induced tumors 0.0237620188581464 0.190671038418191 1.71037457434733 0.6 13.1 13 1 increased kidney iron level 0.0237620188581464 0.190671038418191 1.71037457434733 0.6 13.1 13 1 abnormal inferior vena cava valve morphology 0.0237620188581464 0.190671038418191 1.71037457434733 0.6 13.1 13 1 abnormal adaptive thermogenesis 0.0237620188581464 0.190671038418191 1.71037457434733 0.6 13.1 13 1 delayed intramembranous bone ossification 0.00551594680552945 0.0646594728790371 1.71037457434733 0.6 13.1 13 1 immune system phenotype 0.00551594680552945 0.0646594728790371 1.71037457434733 0.6 13.1 13 1 decreased brown adipose tissue mass 0.00551594680552945 0.0646594728790371 1.71037457434733 0.6 13.1 13 1 kinked neural tube 3.0926545747635e-07 1.61957436941562e-05 1.69941063476818 0.596153846153846 13.1 13 1 embryonic lethality, complete penetrance 5.91696215126586e-37 4.90614778375794e-34 1.69786399752348 0.595611285266458 13.1 13 1 pallor 8.78751864685679e-21 3.10565311807574e-18 1.69408529268688 0.594285714285714 13.1 13 1 increased sarcoma incidence 9.18986819601521e-07 4.31316927124299e-05 1.68710417197526 0.591836734693878 13.1 13 1 prolonged PR interval 0.00103129976351249 0.0181940295158676 1.68445980806934 0.590909090909091 13.1 13 1 hyperlipidemia 0.00418490783821074 0.053937607500255 1.67683781798758 0.588235294117647 13.1 13 1 abnormal dorsal-ventral axis patterning 0.00418490783821074 0.053937607500255 1.67683781798758 0.588235294117647 13.1 13 1 abnormal embryonic-extraembryonic boundary morphology 0.00418490783821074 0.053937607500255 1.67683781798758 0.588235294117647 13.1 13 1 pancytopenia 0.00418490783821074 0.053937607500255 1.67683781798758 0.588235294117647 13.1 13 1 abnormal ductus venosus valve morphology 0.00418490783821074 0.053937607500255 1.67683781798758 0.588235294117647 13.1 13 1 thrombocytopenia 9.47124070484142e-17 2.04867054376461e-14 1.67105561861521 0.586206896551724 13.1 13 1 embryonic lethality between somite formation and embryo turning, complete penetrance 8.21386645798687e-09 6.09910233260965e-07 1.66965137019621 0.585714285714286 13.1 13 1 decreased cell proliferation 1.0996722186779e-20 3.41929330495161e-18 1.66414823450011 0.583783783783784 13.1 13 1 abnormal respiratory function 0.0176216865290067 0.151098681420951 1.66286416950435 0.583333333333333 13.1 13 1 abnormal nucleotide metabolism 0.0176216865290067 0.151098681420951 1.66286416950435 0.583333333333333 13.1 13 1 abnormal rostral-caudal body axis extension 0.0176216865290067 0.151098681420951 1.66286416950435 0.583333333333333 13.1 13 1 increased fibrosarcoma incidence 0.0176216865290067 0.151098681420951 1.66286416950435 0.583333333333333 13.1 13 1 abnormal embryo turning 4.35467614199729e-07 2.25672018817047e-05 1.65854504179135 0.581818181818182 13.1 13 1 decreased embryo size 1.29721987550403e-50 3.22683444031628e-47 1.65789446188479 0.581589958158996 13.1 13 1 testicular atrophy 1.6447991776451e-06 7.11554426850816e-05 1.65336208853575 0.58 13.1 13 1 decreased tumor incidence 0.00316815082032689 0.0441500009275246 1.65036143138778 0.578947368421053 13.1 13 1 preweaning lethality, complete penetrance 1.39578552372293e-76 6.9440329805216e-73 1.64873945455103 0.578378378378378 13.1 13 1 pale yolk sac 8.16324265748594e-10 7.81002542711395e-08 1.64855380659984 0.578313253012048 13.1 13 1 small liver 3.03776310915654e-09 2.55587408967353e-07 1.64459093687243 0.576923076923077 13.1 13 1 abnormal apoptosis 9.86841478347831e-07 4.54586699516709e-05 1.63646950014714 0.574074074074074 13.1 13 1 neurodegeneration 9.86841478347831e-07 4.54586699516709e-05 1.63646950014714 0.574074074074074 13.1 13 1 decreased compact bone area 0.0130802435637299 0.12635769267875 1.62892816604508 0.571428571428571 13.1 13 1 increased lung adenocarcinoma incidence 2.86676141607334e-06 0.000114097104359719 1.62094322405466 0.568627450980392 13.1 13 1 decreased hemoglobin content 9.52423878975358e-15 1.63389958548359e-12 1.61737548401639 0.567375886524823 13.1 13 1 extramedullary hematopoiesis 2.27041398240152e-11 2.56711580964717e-09 1.6135609191956 0.566037735849057 13.1 13 1 abnormal allantois morphology 1.07995129684891e-05 0.000348880370248269 1.61122242510981 0.565217391304348 13.1 13 1 embryonic lethality between implantation and placentation, complete penetrance 1.07995129684891e-05 0.000348880370248269 1.61122242510981 0.565217391304348 13.1 13 1 abnormal hematopoietic stem cell physiology 0.0018101689258962 0.02788108484933 1.61122242510981 0.565217391304348 13.1 13 1 failure of heart looping 5.33529420727595e-05 0.00144255916745641 1.6080444716086 0.564102564102564 13.1 13 1 small heart 8.2893698867179e-06 0.0002844111392167 1.60347616345062 0.5625 13.1 13 1 impaired somite development 0.00972348589538422 0.102488013410035 1.60347616345062 0.5625 13.1 13 1 decreased bone marrow cell number 4.32768922716447e-08 2.79613687079782e-06 1.60103556046211 0.561643835616438 13.1 13 1 decreased birth body size 8.1453154701088e-12 9.42394057297472e-10 1.60035047892148 0.56140350877193 13.1 13 1 increased hepatocellular carcinoma incidence 1.30648932818559e-06 5.80337893546725e-05 1.60035047892148 0.56140350877193 13.1 13 1 abnormal preimplantation embryo development 0.00136748843638025 0.0226775165699725 1.59634960272418 0.56 13.1 13 1 embryonic growth arrest 6.47806186646438e-22 2.47910444505079e-19 1.59336204888252 0.558951965065502 13.1 13 1 pericardial edema 1.60042762827135e-07 8.84680827849995e-06 1.5929959270882 0.558823529411765 13.1 13 1 abnormal oocyte morphology 0.000203454337632606 0.00451868450768845 1.5929959270882 0.558823529411765 13.1 13 1 abnormal direction of heart looping 0.000203454337632606 0.00451868450768845 1.5929959270882 0.558823529411765 13.1 13 1 abnormal trophoblast giant cell morphology 0.000154795131327752 0.00359591543784382 1.58368016143272 0.555555555555556 13.1 13 1 abnormal mammary gland morphology 0.00723982803603173 0.0811517106541875 1.58368016143272 0.555555555555556 13.1 13 1 increased circulating glycerol level 0.00723982803603173 0.0811517106541875 1.58368016143272 0.555555555555556 13.1 13 1 darkened coat color 0.00723982803603173 0.0811517106541875 1.58368016143272 0.555555555555556 13.1 13 1 abnormal pregnancy 0.00723982803603173 0.0811517106541875 1.58368016143272 0.555555555555556 13.1 13 1 increased gastrointestinal tumor incidence 0.00723982803603173 0.0811517106541875 1.58368016143272 0.555555555555556 13.1 13 1 distorted hair follicle pattern 0.0568499150557235 0.351776526619682 1.58368016143272 0.555555555555556 13.1 13 1 multifocal hepatic necrosis 0.0568499150557235 0.351776526619682 1.58368016143272 0.555555555555556 13.1 13 1 increased pheochromocytoma incidence 0.0568499150557235 0.351776526619682 1.58368016143272 0.555555555555556 13.1 13 1 abnormal germ cell morphology 0.0568499150557235 0.351776526619682 1.58368016143272 0.555555555555556 13.1 13 1 abnormal gut-associated lymphoid tissue morphology 0.0568499150557235 0.351776526619682 1.58368016143272 0.555555555555556 13.1 13 1 abnormal thymus physiology 0.0568499150557235 0.351776526619682 1.58368016143272 0.555555555555556 13.1 13 1 short frontal bone 0.0568499150557235 0.351776526619682 1.58368016143272 0.555555555555556 13.1 13 1 abnormal leukopoiesis 0.0568499150557235 0.351776526619682 1.58368016143272 0.555555555555556 13.1 13 1 abnormal optic chiasm morphology 0.0568499150557235 0.351776526619682 1.58368016143272 0.555555555555556 13.1 13 1 abnormal ventricle myocardium morphology 0.0568499150557235 0.351776526619682 1.58368016143272 0.555555555555556 13.1 13 1 prolonged RR interval 0.0568499150557235 0.351776526619682 1.58368016143272 0.555555555555556 13.1 13 1 abnormal heart left ventricle pressure 0.0568499150557235 0.351776526619682 1.58368016143272 0.555555555555556 13.1 13 1 increased myeloid cell number 0.0568499150557235 0.351776526619682 1.58368016143272 0.555555555555556 13.1 13 1 trigeminal neuroma 0.0568499150557235 0.351776526619682 1.58368016143272 0.555555555555556 13.1 13 1 abnormal cell morphology 2.96697598370527e-11 3.20884902585515e-09 1.57534500268833 0.552631578947368 13.1 13 1 thrombocytosis 2.18917801190976e-06 9.00095918119922e-05 1.5727582292849 0.551724137931034 13.1 13 1 decreased trophoblast giant cell number 0.000780457722095719 0.0141707195891467 1.5727582292849 0.551724137931034 13.1 13 1 microcephaly 2.67070101697897e-07 1.42868145800756e-05 1.56990902959417 0.550724637681159 13.1 13 1 small gonad 0.00539917027162332 0.064569404089726 1.56784335981839 0.55 13.1 13 1 abnormal extraembryonic tissue morphology 5.0918831684475e-10 4.96708211039732e-08 1.56504863012174 0.549019607843137 13.1 13 1 impaired hematopoiesis 1.0608561841938e-05 0.000348880370248269 1.56504863012174 0.549019607843137 13.1 13 1 abnormal mitochondrial ATP synthesis coupled electron transport 0.000589759216691235 0.0113087599017567 1.56324557870455 0.548387096774194 13.1 13 1 spleen hyperplasia 1.2014870871199e-07 6.79249802093351e-06 1.55834127884979 0.546666666666667 13.1 13 1 myeloid hyperplasia 0.000445773222325354 0.00901512919133591 1.55488597667939 0.545454545454545 13.1 13 1 abnormal vascular branching morphogenesis 0.00403257531967667 0.0529342010960196 1.55488597667939 0.545454545454545 13.1 13 1 abnormal eye distance/ position 0.0409430606709474 0.289746410864813 1.55488597667939 0.545454545454545 13.1 13 1 impaired myelopoiesis 0.0409430606709474 0.289746410864813 1.55488597667939 0.545454545454545 13.1 13 1 failure of somite differentiation 0.0409430606709474 0.289746410864813 1.55488597667939 0.545454545454545 13.1 13 1 fatigue 0.0409430606709474 0.289746410864813 1.55488597667939 0.545454545454545 13.1 13 1 thin hypoglossal nerve 0.0409430606709474 0.289746410864813 1.55488597667939 0.545454545454545 13.1 13 1 reduced sympathetic cervical ganglion size 0.0409430606709474 0.289746410864813 1.55488597667939 0.545454545454545 13.1 13 1 decreased hematocrit 4.39518438604226e-13 6.24744066301721e-11 1.54246108873789 0.541095890410959 13.1 13 1 decreased circulating alkaline phosphatase level 2.27509724381439e-05 0.000681843902890155 1.5393371169126 0.54 13.1 13 1 abnormal embryo size 2.2077816146957e-10 2.33696032619385e-08 1.53883258163993 0.539823008849557 13.1 13 1 ventricular hypoplasia 0.00225880168542473 0.0333458112314184 1.53495154108094 0.538461538461538 13.1 13 1 heart inflammation 0.00225880168542473 0.0333458112314184 1.53495154108094 0.538461538461538 13.1 13 1 lymphoid hypoplasia 0.0297307557638289 0.228932962854648 1.53495154108094 0.538461538461538 13.1 13 1 axonal dystrophy 0.0297307557638289 0.228932962854648 1.53495154108094 0.538461538461538 13.1 13 1 abnormal exocrine pancreas morphology 0.0297307557638289 0.228932962854648 1.53495154108094 0.538461538461538 13.1 13 1 abnormal embryonic tissue morphology 7.08810308288207e-13 9.79536467703842e-11 1.53196815616144 0.537414965986395 13.1 13 1 internal hemorrhage 1.21554936937928e-06 5.49759828423811e-05 1.53167872329612 0.537313432835821 13.1 13 1 abnormal embryo development 5.61825217655699e-12 6.81726940935879e-10 1.53011450891367 0.536764705882353 13.1 13 1 Leydig cell hyperplasia 0.000145957719809919 0.00345780788597307 1.5296032778716 0.536585365853659 13.1 13 1 small superior cervical ganglion 0.00169365296099718 0.0268341512132515 1.52712015566726 0.535714285714286 13.1 13 1 abnormal ovary morphology 7.06763965664249e-07 3.41373857201907e-05 1.52568624002814 0.535211267605634 13.1 13 1 seminiferous tubule degeneration 5.3890886994556e-07 2.70815315957491e-05 1.52293626482982 0.534246575342466 13.1 13 1 hyperpigmentation 0.0217251541445303 0.178060365517361 1.52033295497541 0.533333333333333 13.1 13 1 audiogenic seizures 0.0217251541445303 0.178060365517361 1.52033295497541 0.533333333333333 13.1 13 1 placental labyrinth hypoplasia 0.0217251541445303 0.178060365517361 1.52033295497541 0.533333333333333 13.1 13 1 decreased thymocyte apoptosis 0.0217251541445303 0.178060365517361 1.52033295497541 0.533333333333333 13.1 13 1 bicuspid aortic valve 0.0217251541445303 0.178060365517361 1.52033295497541 0.533333333333333 13.1 13 1 lethality throughout fetal growth and development, complete penetrance 1.26096545806918e-15 2.41280890534391e-13 1.51533185972878 0.531578947368421 13.1 13 1 embryonic lethality during organogenesis, complete penetrance 6.16138092821783e-43 1.02176233726279e-39 1.51184895411059 0.530357142857143 13.1 13 1 abnormal neural tube closure 1.38908812253755e-07 7.76484652766776e-06 1.51117432271652 0.530120481927711 13.1 13 1 abnormal gastrulation 3.64111843588758e-05 0.00104106690911154 1.50915403618882 0.529411764705882 13.1 13 1 enlarged liver sinusoidal spaces 0.000718381967604697 0.0133356354060947 1.50915403618882 0.529411764705882 13.1 13 1 increased regulatory T cell number 0.0159543862097044 0.144841371155619 1.50915403618882 0.529411764705882 13.1 13 1 abnormal ectoplacental cone morphology 0.0159543862097044 0.144841371155619 1.50915403618882 0.529411764705882 13.1 13 1 increased circulating bilirubin level 2.76070201113359e-05 0.000816510087775508 1.50599019124922 0.528301886792453 13.1 13 1 incomplete somite formation 0.000407323649393533 0.00831980330927097 1.50032857398889 0.526315789473684 13.1 13 1 increased malignant tumor incidence 0.0117639138312593 0.118302907306098 1.50032857398889 0.526315789473684 13.1 13 1 absent amnion 0.0117639138312593 0.118302907306098 1.50032857398889 0.526315789473684 13.1 13 1 increased liver cholesterol level 0.0117639138312593 0.118302907306098 1.50032857398889 0.526315789473684 13.1 13 1 decreased leukocyte cell number 2.92604272642074e-11 3.20884902585515e-09 1.49813831329693 0.525547445255474 13.1 13 1 decreased circulating serum albumin level 1.58870037309221e-08 1.14547599364257e-06 1.49729760717275 0.525252525252525 13.1 13 1 disheveled coat 0.000231621221564706 0.00505401568984392 1.49318415220799 0.523809523809524 13.1 13 1 skin edema 0.000231621221564706 0.00505401568984392 1.49318415220799 0.523809523809524 13.1 13 1 increased incidence of induced tumors 0.00870319005246313 0.0939227126052149 1.49318415220799 0.523809523809524 13.1 13 1 left pulmonary isomerism 0.00870319005246313 0.0939227126052149 1.49318415220799 0.523809523809524 13.1 13 1 abnormal spermatogenesis 2.9328573929487e-14 4.86365517663992e-12 1.4872822385629 0.521739130434783 13.1 13 1 abnormal vertebral artery topology 0.00645701865834624 0.0738475122420058 1.4872822385629 0.521739130434783 13.1 13 1 prenatal lethality, complete penetrance 9.3637782454545e-21 3.10565311807574e-18 1.48683641055374 0.52158273381295 13.1 13 1 astrocytosis 1.75610568595854e-06 7.46720152790063e-05 1.48388661701367 0.520547945205479 13.1 13 1 short stride length 7.54292532444813e-05 0.00197505544679629 1.48232463110102 0.52 13.1 13 1 ruffled hair 0.00480213977540022 0.0589892478583113 1.48232463110102 0.52 13.1 13 1 abnormal atrioventricular cushion morphology 0.0035788645314637 0.0483235437949382 1.47810148400387 0.518518518518518 13.1 13 1 lordosis 0.00267207643124874 0.0387567937185495 1.4744608399546 0.517241379310345 13.1 13 1 increased sacral vertebrae number 1.07713502043314e-05 0.000348880370248269 1.46985314982974 0.515625 13.1 13 1 increased carcinoma incidence 0.00112215501505356 0.0193844486107342 1.46603534944057 0.514285714285714 13.1 13 1 lethality throughout fetal growth and development, incomplete penetrance 3.16503540187986e-13 4.63119150716244e-11 1.46512533370535 0.513966480446927 13.1 13 1 hydrops fetalis 3.56737750540149e-06 0.00014085478642359 1.46490414932526 0.513888888888889 13.1 13 1 increased circulating phosphate level 0.000842421727109553 0.0151301375175813 1.46383409516213 0.513513513513513 13.1 13 1 skin inflammation 0.000842421727109553 0.0151301375175813 1.46383409516213 0.513513513513513 13.1 13 1 increased spleen weight 7.44505336109385e-09 5.69832930329876e-07 1.46315229073961 0.513274336283186 13.1 13 1 abnormal trophoblast layer morphology 0.000116008044885512 0.00282911776130108 1.4532594422559 0.509803921568627 13.1 13 1 failure of chorioallantoic fusion 0.000116008044885512 0.00282911776130108 1.4532594422559 0.509803921568627 13.1 13 1 thymus hypoplasia 4.3233145558471e-10 4.30169798306787e-08 1.44596884304726 0.507246376811594 13.1 13 1 abnormal nervous system morphology 2.37183492180642e-06 9.59339734633084e-05 1.44335407117918 0.506329113924051 13.1 13 1 increased neuron apoptosis 1.80060650377654e-06 7.59154013244771e-05 1.44290859152758 0.506172839506173 13.1 13 1 increased grip strength 4.55455196066812e-07 2.33596866023958e-05 1.4409749161168 0.505494505494505 13.1 13 1 abnormal hepatocyte morphology 2.94940566428945e-08 1.98287745673514e-06 1.43815279524701 0.504504504504504 13.1 13 1 axon degeneration 0.000132088978779342 0.00315933975686167 1.42531214528944 0.5 13.1 13 1 muscular atrophy 0.000542193947879007 0.0105428342862067 1.42531214528944 0.5 13.1 13 1 embryonic lethality, incomplete penetrance 0.000542193947879007 0.0105428342862067 1.42531214528944 0.5 13.1 13 1 decreased hair follicle number 0.00127751980482557 0.0213995320841993 1.42531214528944 0.5 13.1 13 1 bradykinesia 0.00304130223368754 0.0426210665143535 1.42531214528944 0.5 13.1 13 1 increased fatty acid level 0.00304130223368754 0.0426210665143535 1.42531214528944 0.5 13.1 13 1 pancreatic islet hyperplasia 0.00304130223368754 0.0426210665143535 1.42531214528944 0.5 13.1 13 1 abnormal brainstem morphology 0.00546407610193019 0.0646594728790371 1.42531214528944 0.5 13.1 13 1 blindness 0.00989791623758266 0.103449859836079 1.42531214528944 0.5 13.1 13 1 abnormal abdominal fat pad morphology 0.0133738047852496 0.126974577875223 1.42531214528944 0.5 13.1 13 1 abnormal germ layer development 0.0133738047852496 0.126974577875223 1.42531214528944 0.5 13.1 13 1 intestinal inflammation 0.0133738047852496 0.126974577875223 1.42531214528944 0.5 13.1 13 1 increased skin papilloma incidence 0.0133738047852496 0.126974577875223 1.42531214528944 0.5 13.1 13 1 increased myocardial infarction size 0.0133738047852496 0.126974577875223 1.42531214528944 0.5 13.1 13 1 aphakia 0.0133738047852496 0.126974577875223 1.42531214528944 0.5 13.1 13 1 abnormal lysosome physiology 0.0133738047852496 0.126974577875223 1.42531214528944 0.5 13.1 13 1 abnormal mesenteric lymph node morphology 0.0133738047852496 0.126974577875223 1.42531214528944 0.5 13.1 13 1 right pulmonary isomerism 0.0246689443833771 0.196051115506871 1.42531214528944 0.5 13.1 13 1 decreased lactate dehydrogenase level 0.0246689443833771 0.196051115506871 1.42531214528944 0.5 13.1 13 1 primary atelectasis 0.0246689443833771 0.196051115506871 1.42531214528944 0.5 13.1 13 1 increased effector memory CD4-positive, alpha-beta T cell number 0.0246689443833771 0.196051115506871 1.42531214528944 0.5 13.1 13 1 abnormal bone marrow cell number 0.0337268223936764 0.248211451787781 1.42531214528944 0.5 13.1 13 1 intraventricular hemorrhage 0.0337268223936764 0.248211451787781 1.42531214528944 0.5 13.1 13 1 increased pancreatic beta cell number 0.0337268223936764 0.248211451787781 1.42531214528944 0.5 13.1 13 1 decreased liver cholesterol level 0.0337268223936764 0.248211451787781 1.42531214528944 0.5 13.1 13 1 abnormal antigen presentation 0.0463812679639279 0.31695990126448 1.42531214528944 0.5 13.1 13 1 amyloid beta deposits 0.0463812679639279 0.31695990126448 1.42531214528944 0.5 13.1 13 1 increased stomach tumor incidence 0.0463812679639279 0.31695990126448 1.42531214528944 0.5 13.1 13 1 pulmonary alveolar hemorrhage 0.0463812679639279 0.31695990126448 1.42531214528944 0.5 13.1 13 1 abnormal vitelline vein topology 0.0463812679639279 0.31695990126448 1.42531214528944 0.5 13.1 13 1 mesocardia 0.064264434812888 0.375281173332905 1.42531214528944 0.5 13.1 13 1 myocarditis 0.064264434812888 0.375281173332905 1.42531214528944 0.5 13.1 13 1 altered tumor susceptibility 0.064264434812888 0.375281173332905 1.42531214528944 0.5 13.1 13 1 small intestinal inflammation 0.064264434812888 0.375281173332905 1.42531214528944 0.5 13.1 13 1 pale placenta 0.064264434812888 0.375281173332905 1.42531214528944 0.5 13.1 13 1 abnormal B cell proliferation 0.064264434812888 0.375281173332905 1.42531214528944 0.5 13.1 13 1 abnormal pulmonary valve cusp morphology 0.064264434812888 0.375281173332905 1.42531214528944 0.5 13.1 13 1 decreased double-positive T cell number 2.27725598411355e-07 1.23145092619184e-05 1.42531214528944 0.5 13.1 13 1 oxidative stress 8.97935229454704e-07 4.25450263479729e-05 1.42531214528944 0.5 13.1 13 1 small seminiferous tubules 8.14994265163202e-06 0.000281645474970267 1.42531214528944 0.5 13.1 13 1 absent mesoderm 5.70200617395607e-05 0.00153337733596927 1.42531214528944 0.5 13.1 13 1 abnormal embryonic neuroepithelium morphology 7.54089744440683e-05 0.00197505544679629 1.42531214528944 0.5 13.1 13 1 abnormal brown adipose tissue morphology 0.00227460493792675 0.0334797620301349 1.42531214528944 0.5 13.1 13 1 abnormal leukocyte cell number 0.0073454778653757 0.0813892035194746 1.42531214528944 0.5 13.1 13 1 increased leukemia incidence 0.0073454778653757 0.0813892035194746 1.42531214528944 0.5 13.1 13 1 abnormal Mullerian duct morphology 0.0073454778653757 0.0813892035194746 1.42531214528944 0.5 13.1 13 1 decreased myocardial infarction size 0.0181286573908953 0.151579950453284 1.42531214528944 0.5 13.1 13 1 spleen atrophy 0.0181286573908953 0.151579950453284 1.42531214528944 0.5 13.1 13 1 increased cranium width 0.0899378112533004 0.458443248960214 1.42531214528944 0.5 13.1 13 1 absent trophoblast giant cells 0.0899378112533004 0.458443248960214 1.42531214528944 0.5 13.1 13 1 abnormal mammary gland physiology 0.0899378112533004 0.458443248960214 1.42531214528944 0.5 13.1 13 1 abnormal PNS synaptic transmission 0.0899378112533004 0.458443248960214 1.42531214528944 0.5 13.1 13 1 abnormal tibialis anterior morphology 0.0899378112533004 0.458443248960214 1.42531214528944 0.5 13.1 13 1 bifid ureter 0.0899378112533004 0.458443248960214 1.42531214528944 0.5 13.1 13 1 absent seminal vesicle 0.0899378112533004 0.458443248960214 1.42531214528944 0.5 13.1 13 1 increased atrioventricular cushion size 0.0899378112533004 0.458443248960214 1.42531214528944 0.5 13.1 13 1 increased heart rate variability 0.0899378112533004 0.458443248960214 1.42531214528944 0.5 13.1 13 1 abnormal gas homeostasis 0.0899378112533004 0.458443248960214 1.42531214528944 0.5 13.1 13 1 ascites 0.0899378112533004 0.458443248960214 1.42531214528944 0.5 13.1 13 1 increased platelet aggregation 0.0899378112533004 0.458443248960214 1.42531214528944 0.5 13.1 13 1 protruding tongue 0.0899378112533004 0.458443248960214 1.42531214528944 0.5 13.1 13 1 abnormal hippocampus neuron morphology 0.0899378112533004 0.458443248960214 1.42531214528944 0.5 13.1 13 1 decreased trabecular bone connectivity density 0.0899378112533004 0.458443248960214 1.42531214528944 0.5 13.1 13 1 lethality during fetal growth through weaning, complete penetrance 0.0899378112533004 0.458443248960214 1.42531214528944 0.5 13.1 13 1 decreased circulating lactate level 0.0899378112533004 0.458443248960214 1.42531214528944 0.5 13.1 13 1 spleen hypoplasia 1.95209667033306e-07 1.06721768515461e-05 1.41173774390573 0.495238095238095 13.1 13 1 anophthalmia 1.75185203584564e-06 7.46720152790063e-05 1.40929740208394 0.49438202247191 13.1 13 1 prenatal lethality, incomplete penetrance 1.74727372194224e-18 3.95122125757392e-16 1.40655803811458 0.493421052631579 13.1 13 1 abnormal seminiferous tubule morphology 1.23135704893071e-09 1.1558493053642e-07 1.40578732138137 0.493150684931507 13.1 13 1 increased double-negative T cell number 8.44536933772467e-05 0.00218831835704064 1.40194637241585 0.491803278688525 13.1 13 1 incomplete embryo turning 0.000147761222759594 0.00347857121402073 1.4003066690563 0.491228070175439 13.1 13 1 neuron degeneration 0.00060421048634108 0.0115170389637811 1.39498635496414 0.48936170212766 13.1 13 1 abnormal myocardial trabeculae morphology 0.000802440829113701 0.0145168840903297 1.39363854206079 0.488888888888889 13.1 13 1 abnormal left-right axis patterning 0.00106659629930311 0.0186842133416654 1.39216535121295 0.488372093023256 13.1 13 1 arrest of spermatogenesis 5.86190129913142e-06 0.000216021918245769 1.39137614183017 0.488095238095238 13.1 13 1 increased hepatocyte apoptosis 0.00188974001064917 0.0288388237821461 1.38876568002561 0.487179487179487 13.1 13 1 decreased B-1 B cell number 0.00188974001064917 0.0288388237821461 1.38876568002561 0.487179487179487 13.1 13 1 enlarged spleen 1.18419394188647e-16 2.45473535870216e-14 1.38572014125363 0.486111111111111 13.1 13 1 increased mean corpuscular hemoglobin 1.24601251984428e-06 5.58460566326604e-05 1.38212086815946 0.484848484848485 13.1 13 1 decreased lymphocyte cell number 3.96053008142251e-08 2.59258383619434e-06 1.38077114074915 0.484375 13.1 13 1 decreased circulating LDL cholesterol level 9.32457081022227e-05 0.00238169860396797 1.38077114074915 0.484375 13.1 13 1 pericardial effusion 0.000123189910565303 0.00298960880518235 1.37933433415107 0.483870967741935 13.1 13 1 decreased thymus weight 0.00601780360963993 0.0693022522174969 1.37933433415107 0.483870967741935 13.1 13 1 increased cell proliferation 0.000376966752810989 0.00784690207211158 1.37252280657502 0.481481481481481 13.1 13 1 abnormal small intestine morphology 0.000376966752810989 0.00784690207211158 1.37252280657502 0.481481481481481 13.1 13 1 increased brain weight 0.0108430473897226 0.111225073739938 1.37252280657502 0.481481481481481 13.1 13 1 abnormal eye muscle morphology 0.0108430473897226 0.111225073739938 1.37252280657502 0.481481481481481 13.1 13 1 abnormal skin appearance 0.0108430473897226 0.111225073739938 1.37252280657502 0.481481481481481 13.1 13 1 thick interventricular septum 0.0108430473897226 0.111225073739938 1.37252280657502 0.481481481481481 13.1 13 1 abnormal placenta labyrinth morphology 1.93881838257927e-05 0.000591755917382324 1.37118636762022 0.481012658227848 13.1 13 1 abnormal response to infection 1.93881838257927e-05 0.000591755917382324 1.37118636762022 0.481012658227848 13.1 13 1 abnormal egg cylinder morphology 0.0146017098949818 0.137843466276157 1.36829965947787 0.48 13.1 13 1 vertebral transformation 0.000877130381136643 0.0156968476480388 1.36592413923572 0.479166666666667 13.1 13 1 atrial septal defect 0.00116382921666902 0.019897080250613 1.36334205201599 0.478260869565217 13.1 13 1 azoospermia 2.63523994010243e-09 2.30005591263326e-07 1.36256255398739 0.477987421383648 13.1 13 1 lethality, incomplete penetrance 0.00154539844625555 0.0252145249297972 1.36052522959447 0.477272727272727 13.1 13 1 abnormal spleen white pulp morphology 0.00205374553718071 0.0307657388922991 1.3574401383709 0.476190476190476 13.1 13 1 abnormal eye pigmentation 0.0266972640621972 0.211158805579382 1.3574401383709 0.476190476190476 13.1 13 1 abnormal developmental patterning 2.10715943956599e-05 0.000639214525112245 1.35578472356801 0.475609756097561 13.1 13 1 abnormal triglyceride level 0.0362834718802831 0.264290296638958 1.35029571659 0.473684210526316 13.1 13 1 increased left ventricle weight 0.0362834718802831 0.264290296638958 1.35029571659 0.473684210526316 13.1 13 1 decreased circulating magnesium level 0.0362834718802831 0.264290296638958 1.35029571659 0.473684210526316 13.1 13 1 abnormal B cell differentiation 1.00091145189028e-05 0.000336455031969874 1.34699829115266 0.472527472527473 13.1 13 1 abnormal lysosome morphology 0.00484779812402695 0.0594034376035322 1.34612813721781 0.472222222222222 13.1 13 1 decreased circulating alanine transaminase level 0.000144534436277048 0.00344047282525508 1.34147025439006 0.470588235294118 13.1 13 1 increased brain size 0.049524543446096 0.334761689734141 1.34147025439006 0.470588235294118 13.1 13 1 delayed heart development 0.049524543446096 0.334761689734141 1.34147025439006 0.470588235294118 13.1 13 1 abnormal cell cytoskeleton morphology 0.049524543446096 0.334761689734141 1.34147025439006 0.470588235294118 13.1 13 1 failure of primitive streak formation 0.00864412835312729 0.0936918051346585 1.33623013620885 0.46875 13.1 13 1 abnormal spongiotrophoblast layer morphology 0.00864412835312729 0.0936918051346585 1.33623013620885 0.46875 13.1 13 1 abnormal placenta morphology 5.15574355085091e-05 0.00141711735720902 1.33510251584074 0.468354430379747 13.1 13 1 decreased B cell proliferation 5.15574355085091e-05 0.00141711735720902 1.33510251584074 0.468354430379747 13.1 13 1 increased metastatic potential 0.0115673877939 0.117205202188702 1.33029133560348 0.466666666666667 13.1 13 1 abnormal spleen marginal zone morphology 0.0115673877939 0.117205202188702 1.33029133560348 0.466666666666667 13.1 13 1 abnormal fontanelle morphology 0.0679553675559011 0.376898498986185 1.33029133560348 0.466666666666667 13.1 13 1 absent egg cylinders 0.0679553675559011 0.376898498986185 1.33029133560348 0.466666666666667 13.1 13 1 abnormal energy homeostasis 0.0679553675559011 0.376898498986185 1.33029133560348 0.466666666666667 13.1 13 1 abnormal vasculogenesis 0.00291213617881341 0.0411587428681725 1.32587176305995 0.465116279069767 13.1 13 1 shortened head 0.0155048225058093 0.141534847644773 1.32350413491163 0.464285714285714 13.1 13 1 abnormal ovulation 0.0155048225058093 0.141534847644773 1.32350413491163 0.464285714285714 13.1 13 1 decreased body length 2.54661556311071e-13 3.95919138327368e-11 1.3212747624216 0.463503649635036 13.1 13 1 thick ventricular wall 0.0038654788833935 0.0514191375531622 1.32102101270729 0.463414634146341 13.1 13 1 hemopericardium 0.0038654788833935 0.0514191375531622 1.32102101270729 0.463414634146341 13.1 13 1 increased circulating alkaline phosphatase level 1.89442987637004e-08 1.29106693629328e-06 1.3197334678606 0.462962962962963 13.1 13 1 decreased neutrophil cell number 1.95420175094281e-06 8.10179475911706e-05 1.31567274949795 0.461538461538462 13.1 13 1 decreased circulating glycerol level 0.02082133734893 0.17235632830437 1.31567274949795 0.461538461538462 13.1 13 1 pulmonary edema 0.02082133734893 0.17235632830437 1.31567274949795 0.461538461538462 13.1 13 1 abnormal coping response 0.093864731140653 0.469323655703265 1.31567274949795 0.461538461538462 13.1 13 1 tracheoesophageal fistula 0.093864731140653 0.469323655703265 1.31567274949795 0.461538461538462 13.1 13 1 increased circulating ammonia level 0.093864731140653 0.469323655703265 1.31567274949795 0.461538461538462 13.1 13 1 small pituitary gland 0.093864731140653 0.469323655703265 1.31567274949795 0.461538461538462 13.1 13 1 increased circulating thyroxine level 0.093864731140653 0.469323655703265 1.31567274949795 0.461538461538462 13.1 13 1 increased prostaglandin level 0.093864731140653 0.469323655703265 1.31567274949795 0.461538461538462 13.1 13 1 abnormal aorta tunica media morphology 0.093864731140653 0.469323655703265 1.31567274949795 0.461538461538462 13.1 13 1 abnormal testis morphology 2.55552294982096e-06 0.000102530053833542 1.31376597739723 0.460869565217391 13.1 13 1 decreased oocyte number 0.00175183871283826 0.0270664521626408 1.31128717366629 0.46 13.1 13 1 abnormal calcium ion homeostasis 0.00682691955416965 0.077898910050445 1.30974629567138 0.459459459459459 13.1 13 1 decreased circulating cholesterol level 4.56135281999451e-09 3.72011971794634e-07 1.30848328092146 0.459016393442623 13.1 13 1 abnormal male meiosis 0.000608766913435805 0.0115596007417677 1.30848328092146 0.459016393442623 13.1 13 1 thymus atrophy 0.0023155857378523 0.0339824160643515 1.30653613318199 0.458333333333333 13.1 13 1 abnormal tumor morphology 0.0280202716172659 0.219528899678579 1.30653613318199 0.458333333333333 13.1 13 1 increased body temperature 0.0280202716172659 0.219528899678579 1.30653613318199 0.458333333333333 13.1 13 1 increased circulating total protein level 0.0280202716172659 0.219528899678579 1.30653613318199 0.458333333333333 13.1 13 1 double outlet right ventricle 7.46969000468133e-06 0.000263558211158082 1.30542607699407 0.457943925233645 13.1 13 1 abnormal liver development 0.00908480738695091 0.0969890917383707 1.30314253283606 0.457142857142857 13.1 13 1 ovary cysts 0.00908480738695091 0.0969890917383707 1.30314253283606 0.457142857142857 13.1 13 1 increased circulating serum albumin level 0.00908480738695091 0.0969890917383707 1.30314253283606 0.457142857142857 13.1 13 1 abnormal hippocampus pyramidal cell morphology 0.00908480738695091 0.0969890917383707 1.30314253283606 0.457142857142857 13.1 13 1 abnormal neural tube morphology 4.70011340114048e-08 2.95988154059163e-06 1.30213702162245 0.45679012345679 13.1 13 1 small testis 1.19662344861867e-12 1.60897342077781e-10 1.30137195874254 0.456521739130435 13.1 13 1 decreased brain weight 0.00105578355944462 0.0185601526792827 1.3002847641237 0.456140350877193 13.1 13 1 abnormal platelet physiology 0.00139081966573327 0.0229116815795464 1.29573831389949 0.454545454545455 13.1 13 1 enlarged pericardium 0.0121015353891923 0.119081843303186 1.29573831389949 0.454545454545455 13.1 13 1 abnormal ovarian folliculogenesis 0.0121015353891923 0.119081843303186 1.29573831389949 0.454545454545455 13.1 13 1 increased cardiomyocyte apoptosis 0.0121015353891923 0.119081843303186 1.29573831389949 0.454545454545455 13.1 13 1 abnormal T cell subpopulation ratio 0.0121015353891923 0.119081843303186 1.29573831389949 0.454545454545455 13.1 13 1 abnormal enterocyte morphology 0.0378001467929869 0.273336817289404 1.29573831389949 0.454545454545455 13.1 13 1 testis hypoplasia 0.0378001467929869 0.273336817289404 1.29573831389949 0.454545454545455 13.1 13 1 abnormal proximal-distal axis patterning 0.130766770071928 0.577921763998859 1.29573831389949 0.454545454545455 13.1 13 1 vasculitis 0.130766770071928 0.577921763998859 1.29573831389949 0.454545454545455 13.1 13 1 decreased post-tetanic potentiation 0.130766770071928 0.577921763998859 1.29573831389949 0.454545454545455 13.1 13 1 loss of cortex neurons 0.130766770071928 0.577921763998859 1.29573831389949 0.454545454545455 13.1 13 1 aorta dilation 0.130766770071928 0.577921763998859 1.29573831389949 0.454545454545455 13.1 13 1 abnormal pulmonary alveolar sac morphology 0.130766770071928 0.577921763998859 1.29573831389949 0.454545454545455 13.1 13 1 increased subcutaneous adipose tissue amount 0.130766770071928 0.577921763998859 1.29573831389949 0.454545454545455 13.1 13 1 decreased core body temperature 0.130766770071928 0.577921763998859 1.29573831389949 0.454545454545455 13.1 13 1 chylous ascites 0.130766770071928 0.577921763998859 1.29573831389949 0.454545454545455 13.1 13 1 abnormal behavior 2.23014845666347e-12 2.91973383471073e-10 1.29200957055014 0.453237410071942 13.1 13 1 decreased caudal vertebrae number 0.000637491640072673 0.0120590148644926 1.29168913166856 0.453125 13.1 13 1 abnormal pancreas morphology 0.00536212816939538 0.0642809340788964 1.28956813145235 0.452380952380952 13.1 13 1 small cranium 0.0161376335927024 0.146238118622394 1.28737871187434 0.451612903225806 13.1 13 1 small lung 0.00241513502779988 0.0353391081273659 1.28557566045715 0.450980392156863 13.1 13 1 small spleen 6.3606027150197e-05 0.00168319140995867 1.28434720784324 0.450549450549451 13.1 13 1 abnormal liver physiology 2.97397334257503e-05 0.000870324551724163 1.2827809307605 0.45 13.1 13 1 intracranial hemorrhage 0.00110021948411624 0.0191384333338401 1.2827809307605 0.45 13.1 13 1 abnormal cell proliferation 0.051137411007964 0.341030321400296 1.2827809307605 0.45 13.1 13 1 abnormal circulating enzyme level 0.051137411007964 0.341030321400296 1.2827809307605 0.45 13.1 13 1 abnormal hair texture 0.051137411007964 0.341030321400296 1.2827809307605 0.45 13.1 13 1 abnormal physiological neovascularization 0.051137411007964 0.341030321400296 1.2827809307605 0.45 13.1 13 1 dilated vasculature 0.051137411007964 0.341030321400296 1.2827809307605 0.45 13.1 13 1 decreased circulating VLDL cholesterol level 0.051137411007964 0.341030321400296 1.2827809307605 0.45 13.1 13 1 perimembraneous ventricular septal defect 0.000505398678702461 0.0100173642491823 1.28071526098472 0.449275362318841 13.1 13 1 abnormal CD8-positive, alpha-beta T cell physiology 0.0215456625420276 0.178055932137188 1.27786606129398 0.448275862068966 13.1 13 1 decreased total retina thickness 0.00940913004817287 0.0999708680220737 1.27527928789056 0.447368421052632 13.1 13 1 preweaning lethality, incomplete penetrance 3.04288039391422e-16 6.05533198388929e-14 1.2684929605999 0.444987775061125 13.1 13 1 thin ventricular wall 0.000112327449185052 0.00276648049354275 1.26694412914617 0.444444444444444 13.1 13 1 gliosis 0.00113750488311244 0.0195140923913254 1.26694412914617 0.444444444444444 13.1 13 1 trabecula carnea hypoplasia 0.00553556263169721 0.0646594728790371 1.26694412914617 0.444444444444444 13.1 13 1 abnormal Peyer's patch follicle morphology 0.0694090226962714 0.379781228632981 1.26694412914617 0.444444444444444 13.1 13 1 abnormal bile duct morphology 0.0694090226962714 0.379781228632981 1.26694412914617 0.444444444444444 13.1 13 1 absent allantois 0.0694090226962714 0.379781228632981 1.26694412914617 0.444444444444444 13.1 13 1 decreased activity of thyroid 0.0694090226962714 0.379781228632981 1.26694412914617 0.444444444444444 13.1 13 1 increased susceptibility to autoimmune disorder 0.0694090226962714 0.379781228632981 1.26694412914617 0.444444444444444 13.1 13 1 abnormal glycogen homeostasis 0.0694090226962714 0.379781228632981 1.26694412914617 0.444444444444444 13.1 13 1 increased adipocyte glucose uptake 0.0694090226962714 0.379781228632981 1.26694412914617 0.444444444444444 13.1 13 1 abnormal vitelline vasculature morphology 1.49646060963294e-05 0.000477236636725889 1.26418990277846 0.443478260869565 13.1 13 1 male infertility 2.43656467200413e-19 6.06095462161028e-17 1.26379565964034 0.443339960238569 13.1 13 1 distended pericardium 0.00327902318123047 0.04531427868506 1.2608530516022 0.442307692307692 13.1 13 1 abnormal placenta vasculature 0.00327902318123047 0.04531427868506 1.2608530516022 0.442307692307692 13.1 13 1 decreased birth weight 8.88623729712057e-05 0.00229062334472409 1.26027600215067 0.442105263157895 13.1 13 1 increased bone mineral content 3.28510972113487e-05 0.000955755606002687 1.2553207885118 0.440366972477064 13.1 13 1 increased pre-B cell number 0.0385634272562033 0.277455346345276 1.25427468785471 0.44 13.1 13 1 small ovary 0.000150540329212391 0.00351614149216734 1.25302166618852 0.43956043956044 13.1 13 1 abnormal cell differentiation 0.00963333235900788 0.101753351350455 1.25149359098585 0.439024390243902 13.1 13 1 overriding aortic valve 0.00566124633112002 0.0658053749937432 1.24714812712826 0.4375 13.1 13 1 increased circulating follicle stimulating hormone level 0.0219659154457054 0.179535787348886 1.24714812712826 0.4375 13.1 13 1 decreased mast cell number 0.0945775693487424 0.469584239031929 1.24714812712826 0.4375 13.1 13 1 small epididymis 0.0945775693487424 0.469584239031929 1.24714812712826 0.4375 13.1 13 1 abnormal amnion morphology 0.0945775693487424 0.469584239031929 1.24714812712826 0.4375 13.1 13 1 increased heart left ventricle size 0.0945775693487424 0.469584239031929 1.24714812712826 0.4375 13.1 13 1 abnormal pulmonary alveolus wall morphology 0.0945775693487424 0.469584239031929 1.24714812712826 0.4375 13.1 13 1 embryonic lethality between somite formation and embryo turning, incomplete penetrance 0.0945775693487424 0.469584239031929 1.24714812712826 0.4375 13.1 13 1 decreased midbrain size 0.0945775693487424 0.469584239031929 1.24714812712826 0.4375 13.1 13 1 abnormal spleen morphology 3.01250949479583e-07 1.59438667410737e-05 1.24510026485055 0.436781609195402 13.1 13 1 corneal opacity 0.00091439297675531 0.0163050360550454 1.2446387747598 0.436619718309859 13.1 13 1 abnormal rostral-caudal axis patterning 0.00335074091945325 0.0461346097320853 1.24390878134351 0.436363636363636 13.1 13 1 decreased trabecular bone volume 0.0127119495300571 0.123761152469734 1.24257981897028 0.435897435897436 13.1 13 1 abnormal T cell differentiation 9.33530106077898e-05 0.00238169860396797 1.24185612658882 0.435643564356436 13.1 13 1 prenatal lethality 0.00199425838027588 0.0301563387290958 1.24140090073597 0.435483870967742 13.1 13 1 reduced female fertility 4.67837523761275e-09 3.75401883985862e-07 1.24100454029512 0.435344827586207 13.1 13 1 abnormal lymphocyte physiology 0.00743824283861313 0.0820515701155218 1.23940186546908 0.434782608695652 13.1 13 1 abnormal sacral vertebrae morphology 0.0517124196581737 0.343025717065885 1.23940186546908 0.434782608695652 13.1 13 1 dilated heart 0.0517124196581737 0.343025717065885 1.23940186546908 0.434782608695652 13.1 13 1 ventricular septal defect 7.77994033071466e-06 0.000272571853135954 1.23666789076584 0.433823529411765 13.1 13 1 decreased grip strength 1.63589025126741e-08 1.1462752112754e-06 1.23657218084472 0.4337899543379 13.1 13 1 decreased body weight 9.51774541657543e-42 1.18376958618657e-38 1.23649858161621 0.433764135702746 13.1 13 1 liver hemorrhage 0.0291761079376547 0.226191555082379 1.23527052591752 0.433333333333333 13.1 13 1 abnormal fat pad morphology 0.0291761079376547 0.226191555082379 1.23527052591752 0.433333333333333 13.1 13 1 abnormal cellular respiration 0.0291761079376547 0.226191555082379 1.23527052591752 0.433333333333333 13.1 13 1 abnormal myocardial fiber morphology 0.000157047809051592 0.00361718912051698 1.23429092994137 0.43298969072165 13.1 13 1 decreased white adipose tissue amount 0.0015539204577107 0.0252145249297972 1.23385230487743 0.432835820895522 13.1 13 1 abnormal myelopoiesis 0.00977217702516193 0.102783468710741 1.23095139820452 0.431818181818182 13.1 13 1 abnormal visceral yolk sac morphology 0.000726378252186281 0.0134339472290957 1.22685096050231 0.430379746835443 13.1 13 1 infertility 9.66234885517103e-05 0.00245256048747326 1.22550203146382 0.429906542056075 13.1 13 1 abnormal brain morphology 2.35886901446475e-06 9.59339734633084e-05 1.22169612453381 0.428571428571429 13.1 13 1 abnormal somite shape 0.0387783294241607 0.277985862946974 1.22169612453381 0.428571428571429 13.1 13 1 prolonged QRS complex duration 0.0387783294241607 0.277985862946974 1.22169612453381 0.428571428571429 13.1 13 1 midline facial cleft 0.129477328523197 0.577921763998859 1.22169612453381 0.428571428571429 13.1 13 1 abnormal blood flow velocity 0.129477328523197 0.577921763998859 1.22169612453381 0.428571428571429 13.1 13 1 translucent skin 0.129477328523197 0.577921763998859 1.22169612453381 0.428571428571429 13.1 13 1 intestinal obstruction 0.129477328523197 0.577921763998859 1.22169612453381 0.428571428571429 13.1 13 1 abnormal vascular endothelial cell migration 0.129477328523197 0.577921763998859 1.22169612453381 0.428571428571429 13.1 13 1 decreased cornea thickness 0.129477328523197 0.577921763998859 1.22169612453381 0.428571428571429 13.1 13 1 decreased bone mineral density 1.52177082713559e-09 1.40200182685177e-07 1.22169612453381 0.428571428571429 13.1 13 1 increased circulating LDL cholesterol level 0.00751947754134198 0.0823995611633841 1.22169612453381 0.428571428571429 13.1 13 1 decreased circulating creatinine level 0.00751947754134198 0.0823995611633841 1.22169612453381 0.428571428571429 13.1 13 1 holoprosencephaly 0.0221456835130435 0.180024142936914 1.22169612453381 0.428571428571429 13.1 13 1 decreased circulating thyroxine level 0.0221456835130435 0.180024142936914 1.22169612453381 0.428571428571429 13.1 13 1 abnormal associative learning 0.0694675212172889 0.379781228632981 1.22169612453381 0.428571428571429 13.1 13 1 liver degeneration 0.0694675212172889 0.379781228632981 1.22169612453381 0.428571428571429 13.1 13 1 abnormal tumor vascularization 0.0694675212172889 0.379781228632981 1.22169612453381 0.428571428571429 13.1 13 1 increased muscle cell glucose uptake 0.0694675212172889 0.379781228632981 1.22169612453381 0.428571428571429 13.1 13 1 increased circulating triglyceride level 8.15215043130018e-06 0.000281645474970267 1.2188876276958 0.427586206896552 13.1 13 1 sparse hair 0.000734489137439626 0.0134837027998603 1.21672988012513 0.426829268292683 13.1 13 1 kyphosis 6.40425899895267e-06 0.000229217183595608 1.21626636398033 0.426666666666667 13.1 13 1 postnatal growth retardation 1.30891543397329e-19 3.42729172843006e-17 1.215707418041 0.426470588235294 13.1 13 1 decreased platelet aggregation 0.00579206832537189 0.067012883531919 1.21415479043175 0.425925925925926 13.1 13 1 abnormal female reproductive system morphology 0.0168590962233333 0.151098681420951 1.21151532349603 0.425 13.1 13 1 perinatal lethality, incomplete penetrance 4.81677717691273e-08 2.9954333068926e-06 1.21088465440519 0.424778761061947 13.1 13 1 decreased brown adipose tissue amount 0.0292344060136623 0.226191555082379 1.20935575963953 0.424242424242424 13.1 13 1 abnormal QRS complex 0.0292344060136623 0.226191555082379 1.20935575963953 0.424242424242424 13.1 13 1 cardiovascular system phenotype 0.0292344060136623 0.226191555082379 1.20935575963953 0.424242424242424 13.1 13 1 abnormal heart development 5.07609215353695e-06 0.000188459391521241 1.20880903461257 0.424050632911392 13.1 13 1 premature death 2.40793731470823e-26 1.33105423785261e-23 1.20845280611068 0.423925667828107 13.1 13 1 decreased bone resorption 0.0515742931882036 0.343024209373413 1.20603335370645 0.423076923076923 13.1 13 1 abnormal nerve conduction 0.0515742931882036 0.343024209373413 1.20603335370645 0.423076923076923 13.1 13 1 reduced male fertility 6.22856504102472e-08 3.82556926902444e-06 1.20555036077345 0.422907488986784 13.1 13 1 abnormal ovarian follicle morphology 0.01286816446654 0.124550813659604 1.20359692268886 0.422222222222222 13.1 13 1 abnormal ectoderm development 0.01286816446654 0.124550813659604 1.20359692268886 0.422222222222222 13.1 13 1 small placenta 0.01286816446654 0.124550813659604 1.20359692268886 0.422222222222222 13.1 13 1 abnormal tooth morphology 0.00344712957442243 0.0471139275625044 1.20260712258797 0.421875 13.1 13 1 abnormal bone mineralization 7.76894402404623e-05 0.00202358620521623 1.20150280016135 0.421487603305785 13.1 13 1 increased bone marrow cell number 0.02213591432872 0.180024142936914 1.20026285919111 0.421052631578947 13.1 13 1 kyphoscoliosis 0.0935003323806264 0.469323655703265 1.20026285919111 0.421052631578947 13.1 13 1 increased susceptibility to ischemic brain injury 0.0935003323806264 0.469323655703265 1.20026285919111 0.421052631578947 13.1 13 1 eyelids fail to open 0.0935003323806264 0.469323655703265 1.20026285919111 0.421052631578947 13.1 13 1 Leydig cell hypoplasia 0.0935003323806264 0.469323655703265 1.20026285919111 0.421052631578947 13.1 13 1 decreased fertilization frequency 0.0935003323806264 0.469323655703265 1.20026285919111 0.421052631578947 13.1 13 1 decreased susceptibility to weight gain 0.0935003323806264 0.469323655703265 1.20026285919111 0.421052631578947 13.1 13 1 shortened RR interval 0.0935003323806264 0.469323655703265 1.20026285919111 0.421052631578947 13.1 13 1 increased T cell proliferation 0.000211036689523103 0.00466625569056639 1.19886068295374 0.420560747663551 13.1 13 1 increased T cell number 0.000742762363295475 0.0135356877560256 1.19855794035703 0.420454545454545 13.1 13 1 increased monocyte cell number 0.00034867852659215 0.00731930662361159 1.19726220204313 0.42 13.1 13 1 abnormal interventricular septum morphology 0.0098446220318287 0.103109462333364 1.19726220204313 0.42 13.1 13 1 abnormal heart morphology 8.0664004692362e-08 4.77742170648215e-06 1.19701539474525 0.41991341991342 13.1 13 1 abnormal eyelid morphology 0.0385927838534535 0.277455346345276 1.1954230895976 0.419354838709677 13.1 13 1 pale kidney 0.0385927838534535 0.277455346345276 1.1954230895976 0.419354838709677 13.1 13 1 preaxial polydactyly 0.0385927838534535 0.277455346345276 1.1954230895976 0.419354838709677 13.1 13 1 hypoglycemia 0.000577236317307878 0.0111308165837469 1.1954230895976 0.419354838709677 13.1 13 1 increased circulating HDL cholesterol level 0.000271495816200474 0.00587257254607546 1.19454732176639 0.419047619047619 13.1 13 1 increased granulocyte number 0.00205929468364534 0.0307657388922991 1.19418044605332 0.418918918918919 13.1 13 1 decreased oxygen consumption 0.0168219573454972 0.151098681420951 1.19328458675395 0.418604651162791 13.1 13 1 microphthalmia 1.38197889505919e-05 0.000443570645349643 1.19241800390228 0.418300653594771 13.1 13 1 maternal effect 0.00344689818746714 0.0471139275625044 1.19130567367476 0.417910447761194 13.1 13 1 abnormal somite development 0.00159366993060388 0.0256586016335091 1.19076710872283 0.417721518987342 13.1 13 1 increased heart weight 3.71198482772032e-05 0.00104926843851753 1.18946912844299 0.41726618705036 13.1 13 1 hemorrhage 1.03615734159229e-07 6.00988197435554e-06 1.18877098075205 0.417021276595745 13.1 13 1 narrow eye opening 0.0290537325957245 0.226191555082379 1.18776012107454 0.416666666666667 13.1 13 1 curly vibrissae 0.068635382544536 0.379781228632981 1.18776012107454 0.416666666666667 13.1 13 1 abnormal mineral level 0.178268438114099 0.684485178632931 1.18776012107454 0.416666666666667 13.1 13 1 abnormal thymus involution 0.178268438114099 0.684485178632931 1.18776012107454 0.416666666666667 13.1 13 1 abnormal corticospinal tract morphology 0.178268438114099 0.684485178632931 1.18776012107454 0.416666666666667 13.1 13 1 abnormal gastrocnemius morphology 0.178268438114099 0.684485178632931 1.18776012107454 0.416666666666667 13.1 13 1 decreased circulating ketone body level 0.178268438114099 0.684485178632931 1.18776012107454 0.416666666666667 13.1 13 1 abnormal vascular endothelial cell development 0.178268438114099 0.684485178632931 1.18776012107454 0.416666666666667 13.1 13 1 delayed somite formation 0.178268438114099 0.684485178632931 1.18776012107454 0.416666666666667 13.1 13 1 persistent right dorsal aorta 0.178268438114099 0.684485178632931 1.18776012107454 0.416666666666667 13.1 13 1 embryonic lethality between implantation and placentation, incomplete penetrance 0.178268438114099 0.684485178632931 1.18776012107454 0.416666666666667 13.1 13 1 decreased rib number 0.000956598232022978 0.016996700729694 1.18509099720695 0.415730337078652 13.1 13 1 abnormal mesoderm development 0.00979967647470999 0.10285525413857 1.1832780074101 0.415094339622642 13.1 13 1 increased bone trabecula number 0.0219773456272304 0.179535787348886 1.18196616926442 0.414634146341463 13.1 13 1 decreased circulating HDL cholesterol level 9.98626986297162e-05 0.00252191332833928 1.18033662031782 0.4140625 13.1 13 1 abnormal enzyme/coenzyme activity 1.76620638828942e-05 0.000552633759857852 1.18019476998489 0.414012738853503 13.1 13 1 abnormal blood vessel morphology 3.7027152354159e-05 0.00104926843851753 1.17956867196368 0.413793103448276 13.1 13 1 abnormal spermiogenesis 0.0075060678595494 0.0823995611633841 1.17956867196368 0.413793103448276 13.1 13 1 decreased granulocyte number 0.0509425648703722 0.341030321400296 1.17956867196368 0.413793103448276 13.1 13 1 female infertility 3.05928287079708e-08 2.0293243042954e-06 1.17882959384841 0.413533834586466 13.1 13 1 decreased B cell number 1.18358486128811e-06 5.40214191275997e-05 1.17622846941362 0.412621359223301 13.1 13 1 decreased IgM level 0.000738522354045712 0.0135078996741817 1.17551517137274 0.412371134020619 13.1 13 1 abnormal bone marrow cavity morphology 0.126114687480594 0.574176577330827 1.17378647259131 0.411764705882353 13.1 13 1 abnormal interatrial septum morphology 0.126114687480594 0.574176577330827 1.17378647259131 0.411764705882353 13.1 13 1 increased incidence of corneal inflammation 0.126114687480594 0.574176577330827 1.17378647259131 0.411764705882353 13.1 13 1 abnormal testis development 0.126114687480594 0.574176577330827 1.17378647259131 0.411764705882353 13.1 13 1 abnormal melanosome morphology 0.126114687480594 0.574176577330827 1.17378647259131 0.411764705882353 13.1 13 1 abnormal survival 0.126114687480594 0.574176577330827 1.17378647259131 0.411764705882353 13.1 13 1 abnormal leukocyte adhesion 0.0286917159277896 0.224435985441436 1.16948688844262 0.41025641025641 13.1 13 1 enlarged liver 0.000733475456791547 0.0134837027998603 1.16875595913734 0.41 13.1 13 1 decreased T cell number 2.23207775700034e-05 0.000673005263095558 1.16857890172799 0.409937888198758 13.1 13 1 increased osteoclast cell number 0.00743663431256021 0.0820515701155218 1.16828864367987 0.409836065573771 13.1 13 1 teratozoospermia 0.00156739770114181 0.0253175440363004 1.16616448250954 0.409090909090909 13.1 13 1 abnormal vascular development 0.00570543301655856 0.0661644038633539 1.16616448250954 0.409090909090909 13.1 13 1 abnormal long bone epiphysis morphology 0.0913910881264212 0.464423558150098 1.16616448250954 0.409090909090909 13.1 13 1 abnormal sperm midpiece morphology 0.0913910881264212 0.464423558150098 1.16616448250954 0.409090909090909 13.1 13 1 increased bone volume 0.0913910881264212 0.464423558150098 1.16616448250954 0.409090909090909 13.1 13 1 embryonic lethality during organogenesis, incomplete penetrance 5.5705900872712e-07 2.77136856841742e-05 1.16503775354094 0.408695652173913 13.1 13 1 increased circulating free fatty acid level 0.00438488529512874 0.0559353957519627 1.16433949896884 0.408450704225352 13.1 13 1 decreased liver weight 0.00438488529512874 0.0559353957519627 1.16433949896884 0.408450704225352 13.1 13 1 abnormal liver morphology 1.05244593658752e-05 0.000348880370248269 1.16254510174446 0.407821229050279 13.1 13 1 abnormal lipid homeostasis 0.000160804888062872 0.00368665584383774 1.16217759538985 0.407692307692308 13.1 13 1 abnormal cell adhesion 0.0125549070773799 0.122471887666598 1.16136545171732 0.407407407407407 13.1 13 1 abnormal heart valve morphology 0.0672288908501402 0.375281173332905 1.16136545171732 0.407407407407407 13.1 13 1 abnormal fetal cardiomyocyte proliferation 0.0672288908501402 0.375281173332905 1.16136545171732 0.407407407407407 13.1 13 1 decreased circulating fructosamine level 0.0672288908501402 0.375281173332905 1.16136545171732 0.407407407407407 13.1 13 1 decreased heart weight 0.0026014710026023 0.0378430357834691 1.16136545171732 0.407407407407407 13.1 13 1 increased oxygen consumption 0.00200756512358556 0.0301802211704578 1.16013779267745 0.406976744186047 13.1 13 1 limb grasping 1.04312153029501e-05 0.000348290578068299 1.15904504122438 0.406593406593407 13.1 13 1 decreased eosinophil cell number 0.00734321726483324 0.0813892035194746 1.15806611804767 0.40625 13.1 13 1 abnormal auditory brainstem response waveform shape 0.0499690622377021 0.337308120261286 1.15806611804767 0.40625 13.1 13 1 ataxia 3.87300101698368e-06 0.000149365736895301 1.15718411795777 0.405940594059406 13.1 13 1 abnormal angiogenesis 0.00432974726498721 0.0555167336167819 1.15565849618063 0.405405405405405 13.1 13 1 abnormal branching of the mammary ductal tree 0.0374240491501789 0.271802400762248 1.15565849618063 0.405405405405405 13.1 13 1 increased trabecular bone volume 0.0374240491501789 0.271802400762248 1.15565849618063 0.405405405405405 13.1 13 1 decreased circulating glucose level 7.58391744764143e-08 4.59092745787732e-06 1.15455392414127 0.405017921146953 13.1 13 1 decreased total body fat amount 5.08625503813112e-09 4.0165267959845e-07 1.15219844080284 0.404191616766467 13.1 13 1 decreased bone mineral content 3.78997274836263e-06 0.000148160961729843 1.1512136558107 0.403846153846154 13.1 13 1 increased macrophage cell number 0.0123542022985326 0.120750798497445 1.15025190672481 0.403508771929825 13.1 13 1 abnormal eye morphology 0.000155401370680688 0.00359591543784382 1.14845295160013 0.402877697841727 13.1 13 1 abnormal coat/hair pigmentation 0.000699820577343996 0.0130994025872113 1.14534011675045 0.401785714285714 13.1 13 1 increased B cell number 0.000542505643672146 0.0105428342862067 1.14512257826673 0.401709401709402 13.1 13 1 insulin resistance 0.000253677837515787 0.00551112332594341 1.14456884394455 0.401515151515151 13.1 13 1 increased inflammatory response 0.00192123715200997 0.0292298312882251 1.14024971623156 0.4 13.1 13 1 abnormal lung development 0.00322764496621478 0.044853446108711 1.14024971623156 0.4 13.1 13 1 muscular ventricular septal defect 0.0121206099069045 0.119081843303186 1.14024971623156 0.4 13.1 13 1 decreased circulating calcium level 0.0158936635300492 0.144818637476181 1.14024971623156 0.4 13.1 13 1 gastrointestinal hemorrhage 0.0654535361588508 0.375281173332905 1.14024971623156 0.4 13.1 13 1 salivary gland inflammation 0.0654535361588508 0.375281173332905 1.14024971623156 0.4 13.1 13 1 disorganized myocardium 0.0654535361588508 0.375281173332905 1.14024971623156 0.4 13.1 13 1 abnormal microglial cell physiology 0.0654535361588508 0.375281173332905 1.14024971623156 0.4 13.1 13 1 abnormal optic cup morphology 0.0654535361588508 0.375281173332905 1.14024971623156 0.4 13.1 13 1 mandible hypoplasia 0.0886833527367581 0.458443248960214 1.14024971623156 0.4 13.1 13 1 abnormal vascular regression 0.121742279962401 0.567104721734968 1.14024971623156 0.4 13.1 13 1 abnormal lens epithelium morphology 0.121742279962401 0.567104721734968 1.14024971623156 0.4 13.1 13 1 absent placental labyrinth 0.121742279962401 0.567104721734968 1.14024971623156 0.4 13.1 13 1 abnormal optic stalk morphology 0.121742279962401 0.567104721734968 1.14024971623156 0.4 13.1 13 1 decreased hepatocyte number 0.170491969168061 0.664731619601176 1.14024971623156 0.4 13.1 13 1 abnormal prostate gland morphology 0.170491969168061 0.664731619601176 1.14024971623156 0.4 13.1 13 1 abnormal respiratory system morphology 0.170491969168061 0.664731619601176 1.14024971623156 0.4 13.1 13 1 abnormal lymph node B cell domain morphology 0.170491969168061 0.664731619601176 1.14024971623156 0.4 13.1 13 1 abnormal pericyte morphology 0.170491969168061 0.664731619601176 1.14024971623156 0.4 13.1 13 1 abnormal dendritic cell morphology 0.170491969168061 0.664731619601176 1.14024971623156 0.4 13.1 13 1 abnormal coronary vessel morphology 0.170491969168061 0.664731619601176 1.14024971623156 0.4 13.1 13 1 abnormal microglial cell activation 0.170491969168061 0.664731619601176 1.14024971623156 0.4 13.1 13 1 abnormal branching involved in lung morphogenesis 0.170491969168061 0.664731619601176 1.14024971623156 0.4 13.1 13 1 abnormal midbrain development 0.0487608353278429 0.330948370744909 1.14024971623155 0.4 13.1 13 1 abnormal embryonic epiblast morphology 0.0487608353278429 0.330948370744909 1.14024971623155 0.4 13.1 13 1 decreased triglyceride level 0.0487608353278429 0.330948370744909 1.14024971623155 0.4 13.1 13 1 decreased glycogen level 0.0487608353278429 0.330948370744909 1.14024971623155 0.4 13.1 13 1 decreased body size 1.67078446633641e-18 3.95122125757392e-16 1.13953527405346 0.399749373433584 13.1 13 1 abnormal axon morphology 0.00112823951879831 0.0194221162838117 1.13497078236011 0.398148148148148 13.1 13 1 polydactyly 0.00188650079179445 0.0288388237821461 1.13443211563854 0.397959183673469 13.1 13 1 increased circulating cholesterol level 4.17245901804295e-05 0.001166178854762 1.13377102466206 0.397727272727273 13.1 13 1 abnormal lipid level 0.00411116343186626 0.0536906172799552 1.13338074203739 0.397590361445783 13.1 13 1 abnormal cornea morphology 0.00534403347762487 0.0642187597854679 1.13294042317879 0.397435897435897 13.1 13 1 abnormal fertility/fecundity 0.00695766840065051 0.079209153989099 1.13243978666833 0.397260273972603 13.1 13 1 cleft palate 0.000400029501051857 0.00829227819888746 1.13154551992444 0.396946564885496 13.1 13 1 decreased susceptibility to hepatic steatosis 0.0118611378468681 0.118970082234211 1.13120011530908 0.396825396825397 13.1 13 1 curly tail 0.0269165308805288 0.212555144651795 1.12837211502081 0.395833333333333 13.1 13 1 abnormal homeostasis 0.0356278471993105 0.2614285248032 1.12699099860096 0.395348837209302 13.1 13 1 increased startle reflex 0.00393514796013114 0.0519293397921815 1.12103202438496 0.393258426966292 13.1 13 1 abnormal muscle physiology 0.00393514796013114 0.0519293397921815 1.12103202438496 0.393258426966292 13.1 13 1 increased leukocyte cell number 0.000292511183634445 0.00621898777171522 1.12059023836549 0.393103448275862 13.1 13 1 increased bone resorption 0.0856380776551859 0.44612506422466 1.11988811415599 0.392857142857143 13.1 13 1 abnormal postnatal growth 0.116898803570295 0.547619159851428 1.11546167892217 0.391304347826087 13.1 13 1 conjunctivitis 0.116898803570295 0.547619159851428 1.11546167892217 0.391304347826087 13.1 13 1 abnormal osteoclast physiology 0.01475724078407 0.139047865342326 1.11352511350738 0.390625 13.1 13 1 abnormal mammary gland development 0.0459259104636868 0.316018540189269 1.11243874754298 0.390243902439024 13.1 13 1 increased B cell proliferation 0.0193411925643246 0.161176604702705 1.11126031666635 0.389830508474576 13.1 13 1 edema 0.000125916858281093 0.00304095325217687 1.11041760156271 0.38953488372093 13.1 13 1 postnatal lethality, incomplete penetrance 6.90738572748959e-12 8.18196285577635e-10 1.10913374686256 0.389084507042254 13.1 13 1 abnormal neuromuscular synapse morphology 0.0109817384825691 0.112185110781891 1.1085761130029 0.388888888888889 13.1 13 1 abnormal forebrain development 0.0109817384825691 0.112185110781891 1.1085761130029 0.388888888888889 13.1 13 1 abnormal pharyngeal arch morphology 0.0613017188846457 0.375281173332905 1.1085761130029 0.388888888888889 13.1 13 1 cortical renal glomerulopathies 0.162200110525164 0.658508395550602 1.1085761130029 0.388888888888889 13.1 13 1 abnormal iron level 0.162200110525164 0.658508395550602 1.1085761130029 0.388888888888889 13.1 13 1 eye inflammation 0.162200110525164 0.658508395550602 1.1085761130029 0.388888888888889 13.1 13 1 abnormal thymus cortex morphology 0.162200110525164 0.658508395550602 1.1085761130029 0.388888888888889 13.1 13 1 abnormal white adipose tissue morphology 0.162200110525164 0.658508395550602 1.1085761130029 0.388888888888889 13.1 13 1 abnormal neutrophil morphology 0.162200110525164 0.658508395550602 1.1085761130029 0.388888888888889 13.1 13 1 jerky movement 0.162200110525164 0.658508395550602 1.1085761130029 0.388888888888889 13.1 13 1 decreased pulmonary respiratory rate 0.162200110525164 0.658508395550602 1.1085761130029 0.388888888888889 13.1 13 1 small thoracic cage 0.162200110525164 0.658508395550602 1.1085761130029 0.388888888888889 13.1 13 1 atrioventricular block 0.162200110525164 0.658508395550602 1.1085761130029 0.388888888888889 13.1 13 1 decreased fluid intake 0.162200110525164 0.658508395550602 1.1085761130029 0.388888888888889 13.1 13 1 cataract 0.00127430328823857 0.0213995320841993 1.1072672864232 0.388429752066116 13.1 13 1 abnormal craniofacial morphology 0.00281780818937672 0.0405960694619276 1.10703855944811 0.388349514563107 13.1 13 1 rib fusion 0.0143413063332926 0.135642583665648 1.10621241126942 0.388059701492537 13.1 13 1 cardiac hypertrophy 0.00364681071950962 0.04877119174613 1.10534411267345 0.387755102040816 13.1 13 1 impaired coordination 1.19174319367977e-07 6.79249802093351e-06 1.10399900270974 0.38728323699422 13.1 13 1 abnormal capillary morphology 0.0824182218254178 0.432066020633776 1.10346746732086 0.387096774193548 13.1 13 1 decreased double-negative T cell number 0.0824182218254178 0.432066020633776 1.10346746732086 0.387096774193548 13.1 13 1 delayed bone ossification 0.0106688871153905 0.110348676505339 1.10224139235717 0.386666666666667 13.1 13 1 abnormal neurocranium morphology 0.0106688871153905 0.110348676505339 1.10224139235717 0.386666666666667 13.1 13 1 hyperglycemia 0.00612813108647096 0.0704098202198454 1.10137756681457 0.386363636363636 13.1 13 1 omphalocele 0.0443956114975482 0.306761343333753 1.10137756681457 0.386363636363636 13.1 13 1 domed cranium 0.0139160562079954 0.131871199304338 1.09952651208043 0.385714285714286 13.1 13 1 abnormal female meiosis 0.0324227982826209 0.241111242834139 1.09639395791496 0.384615384615385 13.1 13 1 increased susceptibility to otitis media 0.111876514954605 0.535008457391729 1.09639395791496 0.384615384615385 13.1 13 1 abnormal ocular fundus morphology 0.111876514954605 0.535008457391729 1.09639395791496 0.384615384615385 13.1 13 1 absent myocardial trabeculae 0.231020754972503 0.72953037283792 1.09639395791496 0.384615384615385 13.1 13 1 abnormal mast cell morphology 0.231020754972503 0.72953037283792 1.09639395791496 0.384615384615385 13.1 13 1 short hair 0.231020754972503 0.72953037283792 1.09639395791496 0.384615384615385 13.1 13 1 excessive scratching 0.231020754972503 0.72953037283792 1.09639395791496 0.384615384615385 13.1 13 1 abnormal grip strength 0.231020754972503 0.72953037283792 1.09639395791496 0.384615384615385 13.1 13 1 increased synaptic depression 0.231020754972503 0.72953037283792 1.09639395791496 0.384615384615385 13.1 13 1 abnormal dopaminergic neuron morphology 0.231020754972503 0.72953037283792 1.09639395791496 0.384615384615385 13.1 13 1 small interparietal bone 0.231020754972503 0.72953037283792 1.09639395791496 0.384615384615385 13.1 13 1 abnormal hair follicle inner root sheath morphology 0.231020754972503 0.72953037283792 1.09639395791496 0.384615384615385 13.1 13 1 increased rib number 0.0103515092940589 0.107737988991513 1.09639395791496 0.384615384615385 13.1 13 1 abnormal heart ventricle morphology 0.0103515092940589 0.107737988991513 1.09639395791496 0.384615384615385 13.1 13 1 decreased monocyte cell number 0.0181887720847356 0.151827417989194 1.09639395791496 0.384615384615385 13.1 13 1 increased autoantibody level 0.0590838568173487 0.364240629078451 1.09639395791496 0.384615384615385 13.1 13 1 liver inflammation 0.00195102770173515 0.0295925695613792 1.09273931138857 0.383333333333333 13.1 13 1 kinked tail 0.00432579407164893 0.0555167336167819 1.08994458169193 0.382352941176471 13.1 13 1 lung hemorrhage 0.0791281880384835 0.421628617737088 1.08994458169193 0.382352941176471 13.1 13 1 thin skin 0.0791281880384835 0.421628617737088 1.08994458169193 0.382352941176471 13.1 13 1 abnormal endoderm development 0.0791281880384835 0.421628617737088 1.08994458169193 0.382352941176471 13.1 13 1 decreased cytotoxic T cell cytolysis 0.0791281880384835 0.421628617737088 1.08994458169193 0.382352941176471 13.1 13 1 abnormal head morphology 0.031306192166838 0.238486558815534 1.08842018367558 0.381818181818182 13.1 13 1 abnormal cytotoxic T cell physiology 0.0568384950487743 0.351776526619682 1.08595211069672 0.380952380952381 13.1 13 1 abnormal embryonic/fetal subventricular zone morphology 0.153911362267085 0.658508395550602 1.08595211069672 0.380952380952381 13.1 13 1 complete atrioventricular septal defect 0.153911362267085 0.658508395550602 1.08595211069672 0.380952380952381 13.1 13 1 increased bone ossification 0.153911362267085 0.658508395550602 1.08595211069672 0.380952380952381 13.1 13 1 increased total body fat amount 0.00138469826067924 0.0228866240760107 1.08493909566808 0.380597014925373 13.1 13 1 abnormal skeletal muscle fiber morphology 0.0170133383085696 0.151098681420951 1.08404022317789 0.380281690140845 13.1 13 1 abnormal enzyme/coenzyme level 0.0301881790731832 0.231411696285187 1.08127128263337 0.379310344827586 13.1 13 1 short sternum 0.106840891023683 0.522135002792556 1.08127128263337 0.379310344827586 13.1 13 1 impaired glucose tolerance 2.30302005548225e-05 0.00068607932790564 1.08047856175168 0.379032258064516 13.1 13 1 decreased T cell proliferation 0.000981476321882311 0.017376671535105 1.07861459643525 0.378378378378378 13.1 13 1 decreased IgG level 0.00393105454328164 0.0519293397921815 1.07861459643525 0.378378378378378 13.1 13 1 malocclusion 0.0758359526360603 0.411432785566412 1.07861459643525 0.378378378378378 13.1 13 1 abnormal bone structure 0.000190064379688424 0.0042593256259005 1.07821540524486 0.378238341968912 13.1 13 1 cardiomyopathy 0.0545976941946674 0.351776526619682 1.07690250977425 0.377777777777778 13.1 13 1 abnormal placenta development 0.0396985735683047 0.283764947560799 1.07570727946373 0.377358490566038 13.1 13 1 atrioventricular septal defect 0.0396985735683047 0.283764947560799 1.07570727946373 0.377358490566038 13.1 13 1 weight loss 0.000410626205634492 0.00833822601237386 1.07509258958975 0.377142857142857 13.1 13 1 cardiac fibrosis 0.011770842033471 0.118302907306098 1.07317620351205 0.376470588235294 13.1 13 1 lethargy 0.00876859570561526 0.0944237308126318 1.07281559322861 0.376344086021505 13.1 13 1 lung inflammation 0.00200797049395407 0.0301802211704578 1.06898410896708 0.375 13.1 13 1 abnormal retinal pigment epithelium morphology 0.0152787684197865 0.139985032943717 1.06898410896708 0.375 13.1 13 1 abnormal inflammatory response 0.0206322982041701 0.171361742179877 1.06898410896708 0.375 13.1 13 1 impaired ovarian folliculogenesis 0.0725860934693015 0.395093889507413 1.06898410896708 0.375 13.1 13 1 abnormal pancreatic beta cell morphology 0.0725860934693015 0.395093889507413 1.06898410896708 0.375 13.1 13 1 polydipsia 0.101887717578047 0.501376256133318 1.06898410896708 0.375 13.1 13 1 abnormal lumbar vertebrae morphology 0.101887717578047 0.501376256133318 1.06898410896708 0.375 13.1 13 1 decreased body height 0.14585685618575 0.635966572764334 1.06898410896708 0.375 13.1 13 1 ocular hypertelorism 0.14585685618575 0.635966572764334 1.06898410896708 0.375 13.1 13 1 abnormal nursing 0.14585685618575 0.635966572764334 1.06898410896708 0.375 13.1 13 1 increased stereotypic behavior 0.14585685618575 0.635966572764334 1.06898410896708 0.375 13.1 13 1 abnormal primitive streak formation 0.14585685618575 0.635966572764334 1.06898410896708 0.375 13.1 13 1 prolonged QT interval 0.14585685618575 0.635966572764334 1.06898410896708 0.375 13.1 13 1 decreased fatty acid level 0.14585685618575 0.635966572764334 1.06898410896708 0.375 13.1 13 1 mixed cellular infiltration to dermis 0.216040609059652 0.72953037283792 1.06898410896708 0.375 13.1 13 1 disorganized retinal layers 0.216040609059652 0.72953037283792 1.06898410896708 0.375 13.1 13 1 abnormal meiosis 0.216040609059652 0.72953037283792 1.06898410896708 0.375 13.1 13 1 abnormal epicardium morphology 0.216040609059652 0.72953037283792 1.06898410896708 0.375 13.1 13 1 paternal imprinting 0.216040609059652 0.72953037283792 1.06898410896708 0.375 13.1 13 1 increased thymus weight 0.216040609059652 0.72953037283792 1.06898410896708 0.375 13.1 13 1 abnormal level of surface class II molecules 0.216040609059652 0.72953037283792 1.06898410896708 0.375 13.1 13 1 decreased circulating prolactin level 0.216040609059652 0.72953037283792 1.06898410896708 0.375 13.1 13 1 abnormal fertilization 0.216040609059652 0.72953037283792 1.06898410896708 0.375 13.1 13 1 decreased creatinine clearance 0.216040609059652 0.72953037283792 1.06898410896708 0.375 13.1 13 1 kidney degeneration 0.216040609059652 0.72953037283792 1.06898410896708 0.375 13.1 13 1 hydroencephaly 0.00457083450209998 0.0562868852671965 1.06588560430341 0.373913043478261 13.1 13 1 abnormal nervous system physiology 0.00457083450209998 0.0562868852671965 1.06588560430341 0.373913043478261 13.1 13 1 abnormal neuron morphology 0.00816262571380762 0.0890549625574406 1.06538483587292 0.373737373737374 13.1 13 1 increased sensitivity to xenobiotic induced morbidity/mortality 0.00588529872811891 0.0679335526041568 1.06250541739759 0.372727272727273 13.1 13 1 impaired fertilization 0.0258531450323171 0.204807956267162 1.0588033079293 0.371428571428571 13.1 13 1 thick epidermis 0.0258531450323171 0.204807956267162 1.0588033079293 0.371428571428571 13.1 13 1 thick pulmonary interalveolar septum 0.0970725328220439 0.481011803575367 1.0588033079293 0.371428571428571 13.1 13 1 abnormal dermal layer morphology 0.0970725328220439 0.481011803575367 1.0588033079293 0.371428571428571 13.1 13 1 cryptorchism 0.138139823251348 0.607644226945586 1.05578677428848 0.37037037037037 13.1 13 1 abnormal immune system morphology 0.0663197609558865 0.375281173332905 1.05349158564872 0.369565217391304 13.1 13 1 abnormal myelin sheath morphology 0.0663197609558865 0.375281173332905 1.05349158564872 0.369565217391304 13.1 13 1 abnormal reproductive system physiology 0.0924267580888635 0.468728971959323 1.05023000179222 0.368421052631579 13.1 13 1 abnormal retinal outer nuclear layer morphology 0.0924267580888635 0.468728971959323 1.05023000179222 0.368421052631579 13.1 13 1 irregular coat pigmentation 0.202274981109477 0.72953037283792 1.05023000179222 0.368421052631579 13.1 13 1 enlarged adrenal glands 0.202274981109477 0.72953037283792 1.05023000179222 0.368421052631579 13.1 13 1 short vibrissae 0.202274981109477 0.72953037283792 1.05023000179222 0.368421052631579 13.1 13 1 oliguria 0.202274981109477 0.72953037283792 1.05023000179222 0.368421052631579 13.1 13 1 abnormal respiratory system physiology 0.0633337697833078 0.375281173332905 1.04716810674326 0.36734693877551 13.1 13 1 increased fluid intake 0.0633337697833078 0.375281173332905 1.04716810674326 0.36734693877551 13.1 13 1 hunched posture 0.02286207130738 0.185242353019895 1.04643170160491 0.367088607594937 13.1 13 1 abnormal synaptic transmission 0.130801991208586 0.577921763998859 1.04522890654559 0.366666666666667 13.1 13 1 abnormal brain vasculature morphology 0.130801991208586 0.577921763998859 1.04522890654559 0.366666666666667 13.1 13 1 decreased litter size 4.81187176291397e-05 0.00133737776650821 1.04489075419796 0.366548042704626 13.1 13 1 increased neutrophil cell number 0.00314519315150253 0.0439531908110255 1.04195232690125 0.36551724137931 13.1 13 1 cachexia 0.0111762171704937 0.113704867941117 1.04157426001921 0.365384615384615 13.1 13 1 absent corpus luteum 0.0604565897143901 0.372241997313231 1.04157426001921 0.365384615384615 13.1 13 1 neonatal lethality, incomplete penetrance 0.000105420621819249 0.00264882623005435 1.04157426001921 0.365384615384615 13.1 13 1 increased circulating calcium level 0.0576915995532309 0.356098893023975 1.0365906511196 0.363636363636364 13.1 13 1 abnormal T-helper 2 physiology 0.0576915995532309 0.356098893023975 1.0365906511196 0.363636363636364 13.1 13 1 abnormal gametogenesis 0.0837004286204042 0.437865018282346 1.0365906511196 0.363636363636364 13.1 13 1 abnormal astrocyte morphology 0.0837004286204042 0.437865018282346 1.0365906511196 0.363636363636364 13.1 13 1 abnormal skeleton physiology 0.123854076889315 0.574176577330827 1.0365906511196 0.363636363636364 13.1 13 1 dilated heart atrium 0.123854076889315 0.574176577330827 1.0365906511196 0.363636363636364 13.1 13 1 increased osteoblast cell number 0.123854076889315 0.574176577330827 1.0365906511196 0.363636363636364 13.1 13 1 abnormal tail movements 0.189637233204608 0.697298769543921 1.0365906511196 0.363636363636364 13.1 13 1 intracerebral hemorrhage 0.189637233204608 0.697298769543921 1.0365906511196 0.363636363636364 13.1 13 1 abnormal oogenesis 0.189637233204608 0.697298769543921 1.0365906511196 0.363636363636364 13.1 13 1 abnormal chorion morphology 0.189637233204608 0.697298769543921 1.0365906511196 0.363636363636364 13.1 13 1 abnormal circulating lipid level 0.189637233204608 0.697298769543921 1.0365906511196 0.363636363636364 13.1 13 1 increased circulating insulin level 0.0025829393743298 0.0376836462970403 1.03335130533485 0.3625 13.1 13 1 dermatitis 0.0550397871717532 0.351776526619682 1.03212258796822 0.362068965517241 13.1 13 1 increased respiratory quotient 0.0796285061164021 0.421628617737088 1.03107687106045 0.361702127659574 13.1 13 1 decreased bone trabecula number 0.0796285061164021 0.421628617737088 1.03107687106045 0.361702127659574 13.1 13 1 abnormal retinal blood vessel morphology 0.117290818960573 0.548938687045016 1.02939210493127 0.361111111111111 13.1 13 1 increased body length 0.0757488251921869 0.411408739444465 1.0262247446084 0.36 13.1 13 1 increased circulating chloride level 0.0757488251921869 0.411408739444465 1.0262247446084 0.36 13.1 13 1 spontaneous skin ulceration 0.178016951875808 0.684485178632931 1.0262247446084 0.36 13.1 13 1 decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 0.178016951875808 0.684485178632931 1.0262247446084 0.36 13.1 13 1 decreased startle reflex 0.0111456943423919 0.113626699494671 1.02330102738729 0.358974358974359 13.1 13 1 increased circulating alanine transaminase level 0.033590358599118 0.248211451787781 1.02330102738729 0.358974358974359 13.1 13 1 abnormal circulating hormone level 0.111098782800912 0.535008457391729 1.02330102738729 0.358974358974359 13.1 13 1 abnormal locomotor behavior 0.0227657178039267 0.184762554770857 1.02250653901199 0.358695652173913 13.1 13 1 enlarged kidney 0.0720566575607323 0.393503700729575 1.02192191549054 0.358490566037736 13.1 13 1 enlarged heart 0.000591010567729997 0.0113087599017567 1.01983541430193 0.357758620689655 13.1 13 1 abnormal retinal inner nuclear layer morphology 0.16730745969366 0.658508395550602 1.01808010377817 0.357142857142857 13.1 13 1 megacephaly 0.287433769666562 0.748290426002694 1.01808010377817 0.357142857142857 13.1 13 1 extended life span 0.287433769666562 0.748290426002694 1.01808010377817 0.357142857142857 13.1 13 1 absent visceral yolk sac blood islands 0.287433769666562 0.748290426002694 1.01808010377817 0.357142857142857 13.1 13 1 abnormal adrenal gland secretion 0.287433769666562 0.748290426002694 1.01808010377817 0.357142857142857 13.1 13 1 abnormal fluid regulation 0.287433769666562 0.748290426002694 1.01808010377817 0.357142857142857 13.1 13 1 increased lactate dehydrogenase level 0.287433769666562 0.748290426002694 1.01808010377817 0.357142857142857 13.1 13 1 absent otoliths 0.287433769666562 0.748290426002694 1.01808010377817 0.357142857142857 13.1 13 1 abnormal ventral body wall morphology 0.287433769666562 0.748290426002694 1.01808010377817 0.357142857142857 13.1 13 1 abnormal imprinting 0.287433769666562 0.748290426002694 1.01808010377817 0.357142857142857 13.1 13 1 abnormal sagittal suture morphology 0.287433769666562 0.748290426002694 1.01808010377817 0.357142857142857 13.1 13 1 split sternum 0.287433769666562 0.748290426002694 1.01808010377817 0.357142857142857 13.1 13 1 abnormal positive T cell selection 0.287433769666562 0.748290426002694 1.01808010377817 0.357142857142857 13.1 13 1 abnormal viscerocranium morphology 0.287433769666562 0.748290426002694 1.01808010377817 0.357142857142857 13.1 13 1 abnormal glucose tolerance 0.287433769666562 0.748290426002694 1.01808010377817 0.357142857142857 13.1 13 1 spina bifida occulta 0.287433769666562 0.748290426002694 1.01808010377817 0.357142857142857 13.1 13 1 increased pulmonary respiratory rate 0.287433769666562 0.748290426002694 1.01808010377817 0.357142857142857 13.1 13 1 decreased response to antigen 0.287433769666562 0.748290426002694 1.01808010377817 0.357142857142857 13.1 13 1 abnormal retina morphology 0.00110910791253677 0.0192258253131373 1.01808010377817 0.357142857142857 13.1 13 1 abnormal reproductive system morphology 0.105260564519932 0.51542451622703 1.01808010377817 0.357142857142857 13.1 13 1 no abnormal phenotype detected 3.00356247594845e-20 8.78983724579033e-18 1.01702388234486 0.356772334293948 13.1 13 1 decreased percent body fat/body weight 0.0434206963885525 0.300442231617592 1.01529084321988 0.356164383561644 13.1 13 1 increased hemoglobin content 0.0652093403193322 0.375281173332905 1.01462898478232 0.355932203389831 13.1 13 1 abnormal rib morphology 0.00860160648953145 0.0936389327908511 1.01355530331694 0.355555555555556 13.1 13 1 abnormal cell migration 0.0997571096828799 0.492352798286039 1.01355530331694 0.355555555555556 13.1 13 1 lethality at weaning, complete penetrance 0.0997571096828799 0.492352798286039 1.01355530331694 0.355555555555556 13.1 13 1 absent mature ovarian follicles 0.157413064369328 0.658508395550602 1.01151184504412 0.354838709677419 13.1 13 1 autoimmune response 0.157413064369328 0.658508395550602 1.01151184504412 0.354838709677419 13.1 13 1 abnormal postnatal growth/weight/body size 0.157413064369328 0.658508395550602 1.01151184504412 0.354838709677419 13.1 13 1 abnormal motor coordination/ balance 0.0243462961305481 0.194731227089191 1.00779646636627 0.353535353535354 13.1 13 1 distended abdomen 0.0896771987801139 0.458443248960214 1.00610269079255 0.352941176470588 13.1 13 1 impaired synaptic plasticity 0.148250016262496 0.645270193268519 1.00610269079255 0.352941176470588 13.1 13 1 abnormal spleen red pulp morphology 0.148250016262496 0.645270193268519 1.00610269079255 0.352941176470588 13.1 13 1 abnormal adipose tissue morphology 0.265091111739138 0.729844095684676 1.00610269079255 0.352941176470588 13.1 13 1 absence seizures 0.265091111739138 0.729844095684676 1.00610269079255 0.352941176470588 13.1 13 1 aminoaciduria 0.265091111739138 0.729844095684676 1.00610269079255 0.352941176470588 13.1 13 1 decreased growth hormone level 0.265091111739138 0.729844095684676 1.00610269079255 0.352941176470588 13.1 13 1 enhanced behavioral response to cocaine 0.265091111739138 0.729844095684676 1.00610269079255 0.352941176470588 13.1 13 1 increased circulating magnesium level 0.265091111739138 0.729844095684676 1.00610269079255 0.352941176470588 13.1 13 1 abnormal electroretinogram waveform feature 0.265091111739138 0.729844095684676 1.00610269079255 0.352941176470588 13.1 13 1 abnormal suckling behavior 0.0342343093580774 0.251574134499904 1.00419719327211 0.352272727272727 13.1 13 1 abnormal CD4-positive, alpha-beta T cell physiology 0.0534562813354712 0.351776526619682 1.00374094738693 0.352112676056338 13.1 13 1 diluted coat color 0.0850633798592608 0.44359571781952 1.00299743557405 0.351851851851852 13.1 13 1 impaired limb coordination 0.0850633798592608 0.44359571781952 1.00299743557405 0.351851851851852 13.1 13 1 abnormal neuronal precursor proliferation 0.0850633798592608 0.44359571781952 1.00299743557405 0.351851851851852 13.1 13 1 abnormal lens morphology 0.0132739055013611 0.126974577875223 1.00217260215664 0.3515625 13.1 13 1 abnormal intestine morphology 0.0508787661817329 0.341030321400296 1.00157069668988 0.351351351351351 13.1 13 1 increased white adipose tissue amount 0.139745538219685 0.613081175170134 1.00157069668988 0.351351351351351 13.1 13 1 abnormal long bone metaphysis morphology 0.139745538219685 0.613081175170134 1.00157069668988 0.351351351351351 13.1 13 1 abnormal breathing pattern 0.139745538219685 0.613081175170134 1.00157069668988 0.351351351351351 13.1 13 1 absent vitelline blood vessels 0.0807101792749357 0.424885693552779 1.00021904932593 0.350877192982456 13.1 13 1 abnormal cytokine secretion 0.00766427412458035 0.083801678614917 0.999569556436753 0.350649350649351 13.1 13 1 obese 0.0484311920374512 0.330514650735692 0.999569556436753 0.350649350649351 13.1 13 1 hypoactivity 5.8174725403731e-05 0.00154965166152033 0.99809656858465 0.350132625994695 13.1 13 1 waved hair 0.245638743265595 0.72953037283792 0.997718501702611 0.35 13.1 13 1 increased urine glucose level 0.245638743265595 0.72953037283792 0.997718501702611 0.35 13.1 13 1 abnormal thymocyte activation 0.245638743265595 0.72953037283792 0.997718501702611 0.35 13.1 13 1 abnormal postnatal subventricular zone morphology 0.245638743265595 0.72953037283792 0.997718501702611 0.35 13.1 13 1 abnormal neuron proliferation 0.245638743265595 0.72953037283792 0.997718501702611 0.35 13.1 13 1 decreased muscle cell glucose uptake 0.245638743265595 0.72953037283792 0.997718501702611 0.35 13.1 13 1 abnormal eating behavior 0.0766012479836196 0.414823332743425 0.997718501702611 0.35 13.1 13 1 increased insulin sensitivity 0.0105915492145032 0.11000617399197 0.996721779922688 0.34965034965035 13.1 13 1 postnatal lethality 0.00641513204183802 0.0735375159173828 0.996001258154069 0.349397590361446 13.1 13 1 abnormal male reproductive system morphology 0.124467419879652 0.574176577330827 0.994403822294961 0.348837209302326 13.1 13 1 delayed endochondral bone ossification 0.124467419879652 0.574176577330827 0.994403822294961 0.348837209302326 13.1 13 1 abnormal skin morphology 0.0690559561874351 0.379781228632981 0.993399373989612 0.348484848484849 13.1 13 1 abnormal pulmonary artery morphology 0.228431062342908 0.72953037283792 0.991521492375265 0.347826086956522 13.1 13 1 failure of embryo implantation 0.228431062342908 0.72953037283792 0.991521492375265 0.347826086956522 13.1 13 1 pancreas inflammation 0.228431062342908 0.72953037283792 0.991521492375265 0.347826086956522 13.1 13 1 abnormal nasal cavity morphology 0.228431062342908 0.72953037283792 0.991521492375265 0.347826086956522 13.1 13 1 abnormal cardiovascular development 0.228431062342908 0.72953037283792 0.991521492375265 0.347826086956522 13.1 13 1 abnormal Wolffian duct morphology 0.228431062342908 0.72953037283792 0.991521492375265 0.347826086956522 13.1 13 1 decreased epididymis weight 0.228431062342908 0.72953037283792 0.991521492375265 0.347826086956522 13.1 13 1 abnormal lens development 0.228431062342908 0.72953037283792 0.991521492375265 0.347826086956522 13.1 13 1 decreased effector memory CD8-positive, alpha-beta T cell number 0.228431062342908 0.72953037283792 0.991521492375265 0.347826086956522 13.1 13 1 perinatal lethality, complete penetrance 0.00274928965036699 0.0397608023563249 0.990357734755106 0.347417840375587 13.1 13 1 alopecia 0.0361195593618458 0.264257070331151 0.990216858832666 0.347368421052632 13.1 13 1 increased susceptibility to bacterial infection induced morbidity/mortality 0.0623168998912688 0.375281173332905 0.989800100895447 0.347222222222222 13.1 13 1 improved glucose tolerance 0.00411178395651516 0.0536906172799552 0.988992100813083 0.346938775510204 13.1 13 1 abnormal pulmonary alveolus morphology 0.0327857820260122 0.243446665043897 0.987840100695654 0.346534653465347 13.1 13 1 abnormal snout morphology 0.10514693299138 0.515375361213906 0.986754562123461 0.346153846153846 13.1 13 1 eyelids open at birth 0.10514693299138 0.515375361213906 0.986754562123461 0.346153846153846 13.1 13 1 abnormal Schwann cell morphology 0.21303247730468 0.72953037283792 0.986754562123461 0.346153846153846 13.1 13 1 increased urine protein level 0.056288103857745 0.351776526619682 0.986754562123461 0.346153846153846 13.1 13 1 abnormal dendritic cell physiology 0.0297727893400919 0.228932962854648 0.985729894873073 0.345794392523364 13.1 13 1 abnormal contextual conditioning behavior 0.0995095972429993 0.492107600679842 0.984761118563616 0.345454545454545 13.1 13 1 increased bone mineral density 0.0270480546683101 0.213255264619402 0.983843781704218 0.345132743362832 13.1 13 1 abnormal microglial cell morphology 0.199131969519964 0.727907089171067 0.982973893303065 0.344827586206897 13.1 13 1 abnormal circulating glucose level 0.199131969519964 0.727907089171067 0.982973893303065 0.344827586206897 13.1 13 1 focal hair loss 0.199131969519964 0.727907089171067 0.982973893303065 0.344827586206897 13.1 13 1 enlarged epididymis 0.199131969519964 0.727907089171067 0.982973893303065 0.344827586206897 13.1 13 1 decreased bone strength 0.199131969519964 0.727907089171067 0.982973893303065 0.344827586206897 13.1 13 1 abnormal long bone morphology 0.0892541574752039 0.458443248960214 0.981362460691092 0.344262295081967 13.1 13 1 abnormal NK cell physiology 0.0892541574752039 0.458443248960214 0.981362460691092 0.344262295081967 13.1 13 1 retinal degeneration 0.0416848796894123 0.294577097236969 0.979902099886493 0.34375 13.1 13 1 scoliosis 0.186497769831428 0.688298519963911 0.979902099886493 0.34375 13.1 13 1 neonatal lethality 0.186497769831428 0.688298519963911 0.979902099886493 0.34375 13.1 13 1 abnormal heart atrium morphology 0.186497769831428 0.688298519963911 0.979902099886493 0.34375 13.1 13 1 decreased compact bone thickness 0.0801925751398131 0.423073235758823 0.978572517661409 0.343283582089552 13.1 13 1 impaired balance 0.0377675610889822 0.273336817289404 0.978155393826089 0.343137254901961 13.1 13 1 abnormal humoral immune response 0.035957710835248 0.263460399713341 0.977356899627047 0.342857142857143 13.1 13 1 abnormal intestinal goblet cell morphology 0.174951311970558 0.681050686270365 0.977356899627047 0.342857142857143 13.1 13 1 decreased neuron apoptosis 0.164351303887712 0.658508395550602 0.975213573092777 0.342105263157895 13.1 13 1 abnormal compact bone morphology 0.164351303887712 0.658508395550602 0.975213573092777 0.342105263157895 13.1 13 1 hyporesponsive to tactile stimuli 0.164351303887712 0.658508395550602 0.975213573092777 0.342105263157895 13.1 13 1 abnormal myocardium layer morphology 0.0650151815457448 0.375281173332905 0.974263998045949 0.341772151898734 13.1 13 1 liver fibrosis 0.154583489584204 0.658508395550602 0.973383904100108 0.341463414634146 13.1 13 1 abnormal cholesterol homeostasis 0.154583489584204 0.658508395550602 0.973383904100108 0.341463414634146 13.1 13 1 lethality at weaning, incomplete penetrance 0.154583489584204 0.658508395550602 0.973383904100108 0.341463414634146 13.1 13 1 abnormal glucose homeostasis 0.00918956692850188 0.0978974207051325 0.971091791296105 0.340659340659341 13.1 13 1 increased thermal nociceptive threshold 0.0529587512617804 0.350825282992487 0.971091791296105 0.340659340659341 13.1 13 1 decreased heart rate 0.0455223788963453 0.313675671758058 0.969212258796822 0.34 13.1 13 1 abnormal circulating protein level 0.12940624892896 0.577921763998859 0.969212258796822 0.34 13.1 13 1 decreased respiratory quotient 0.12940624892896 0.577921763998859 0.969212258796822 0.34 13.1 13 1 reduced fertility 0.0240689643516305 0.192823023589955 0.96388015580725 0.338129496402878 13.1 13 1 respiratory failure 0.0198736265136142 0.165336608537175 0.962793634566379 0.337748344370861 13.1 13 1 increased body weight 0.00730388312766039 0.0813892035194746 0.954450097292038 0.334821428571429 13.1 13 1 abnormal heart left ventricle morphology 0.100236736905527 0.494229698815655 0.950208096859629 0.333333333333333 13.1 13 1 hyperkeratosis 0.105909618779397 0.518092776231562 0.950208096859629 0.333333333333333 13.1 13 1 abnormal cervical vertebrae morphology 0.149270774003383 0.648012304246798 0.950208096859629 0.333333333333333 13.1 13 1 abnormal response to novel object 0.149270774003383 0.648012304246798 0.950208096859629 0.333333333333333 13.1 13 1 abnormal dendritic spine morphology 0.149270774003383 0.648012304246798 0.950208096859629 0.333333333333333 13.1 13 1 abnormal tooth development 0.217819616302484 0.72953037283792 0.950208096859629 0.333333333333333 13.1 13 1 heart right ventricle hypertrophy 0.20378155847555 0.72953037283792 0.950208096859629 0.333333333333333 13.1 13 1 belly spot 0.217819616302484 0.72953037283792 0.950208096859629 0.333333333333333 13.1 13 1 thin epidermis 0.250478804331347 0.72953037283792 0.950208096859629 0.333333333333333 13.1 13 1 abnormal epidermis stratum basale morphology 0.217819616302484 0.72953037283792 0.950208096859629 0.333333333333333 13.1 13 1 reduced long term depression 0.20378155847555 0.72953037283792 0.950208096859629 0.333333333333333 13.1 13 1 abnormal brain commissure morphology 0.250478804331347 0.72953037283792 0.950208096859629 0.333333333333333 13.1 13 1 abnormal locomotor coordination 0.217819616302484 0.72953037283792 0.950208096859629 0.333333333333333 13.1 13 1 abnormal bone trabecula morphology 0.250478804331347 0.72953037283792 0.950208096859629 0.333333333333333 13.1 13 1 abnormal foregut morphology 0.269718165421488 0.731859309429029 0.950208096859629 0.333333333333333 13.1 13 1 abnormal adrenal gland morphology 0.269718165421488 0.731859309429029 0.950208096859629 0.333333333333333 13.1 13 1 abnormal cellular extravasation 0.269718165421488 0.731859309429029 0.950208096859629 0.333333333333333 13.1 13 1 abnormal heart shape 0.316536612346124 0.807988530744981 0.950208096859629 0.333333333333333 13.1 13 1 underdeveloped hair follicles 0.316536612346124 0.807988530744981 0.950208096859629 0.333333333333333 13.1 13 1 absent spleen 0.316536612346124 0.807988530744981 0.950208096859629 0.333333333333333 13.1 13 1 acidosis 0.316536612346124 0.807988530744981 0.950208096859629 0.333333333333333 13.1 13 1 decreased heart rate variability 0.316536612346124 0.807988530744981 0.950208096859629 0.333333333333333 13.1 13 1 long tibia 0.316536612346124 0.807988530744981 0.950208096859629 0.333333333333333 13.1 13 1 abnormal macrophage chemotaxis 0.316536612346124 0.807988530744981 0.950208096859629 0.333333333333333 13.1 13 1 abnormal retinal pigmentation 0.076627666892705 0.414823332743425 0.950208096859629 0.333333333333333 13.1 13 1 decreased exploration in new environment 0.0807923348946591 0.424885693552779 0.950208096859629 0.333333333333333 13.1 13 1 increased food intake 0.0807923348946591 0.424885693552779 0.950208096859629 0.333333333333333 13.1 13 1 skin lesions 0.11842924175422 0.553745749743651 0.950208096859629 0.333333333333333 13.1 13 1 epidermal hyperplasia 0.125347337519799 0.574176577330827 0.950208096859629 0.333333333333333 13.1 13 1 abnormal craniofacial bone morphology 0.132759773618342 0.585531802970968 0.950208096859629 0.333333333333333 13.1 13 1 abnormal facial morphology 0.132759773618342 0.585531802970968 0.950208096859629 0.333333333333333 13.1 13 1 abnormal metabolism 0.168452137161936 0.66248963034042 0.950208096859629 0.333333333333333 13.1 13 1 abnormal iris morphology 0.190977564431112 0.701190688593934 0.950208096859629 0.333333333333333 13.1 13 1 impaired macrophage chemotaxis 0.190977564431112 0.701190688593934 0.950208096859629 0.333333333333333 13.1 13 1 abnormal response to new environment 0.233296958675655 0.72953037283792 0.950208096859629 0.333333333333333 13.1 13 1 arrested T cell differentiation 0.233296958675655 0.72953037283792 0.950208096859629 0.333333333333333 13.1 13 1 trunk curl 0.29150243376485 0.75611293429621 0.950208096859629 0.333333333333333 13.1 13 1 abnormal bile salt homeostasis 0.29150243376485 0.75611293429621 0.950208096859629 0.333333333333333 13.1 13 1 abnormal enteric neuron morphology 0.345904669915814 0.856294064142105 0.950208096859629 0.333333333333333 13.1 13 1 abnormal bronchus morphology 0.345904669915814 0.856294064142105 0.950208096859629 0.333333333333333 13.1 13 1 abnormal olfactory nerve morphology 0.345904669915814 0.856294064142105 0.950208096859629 0.333333333333333 13.1 13 1 abnormal neurotransmitter secretion 0.345904669915814 0.856294064142105 0.950208096859629 0.333333333333333 13.1 13 1 abnormal cerebral aqueduct morphology 0.345904669915814 0.856294064142105 0.950208096859629 0.333333333333333 13.1 13 1 absent chorion 0.345904669915814 0.856294064142105 0.950208096859629 0.333333333333333 13.1 13 1 decreased trabecular bone mass 0.345904669915814 0.856294064142105 0.950208096859629 0.333333333333333 13.1 13 1 increased blood urea nitrogen level 0.0331722344628445 0.24594913033182 0.943654937570942 0.331034482758621 13.1 13 1 abnormal cardiovascular system physiology 0.0403778043557804 0.288205992352952 0.94306367507873 0.330827067669173 13.1 13 1 abnormal gait 0.00335693039658591 0.0461346097320853 0.940982775530895 0.330097087378641 13.1 13 1 abnormal locomotor activation 0.0824130531487687 0.432066020633776 0.939766249641392 0.32967032967033 13.1 13 1 decreased food intake 0.102129668563985 0.502070258009707 0.938180146266469 0.329113924050633 13.1 13 1 abnormal cranium morphology 0.0454001840707424 0.313267566923639 0.936025886458739 0.328358208955224 13.1 13 1 glomerulosclerosis 0.151535116477134 0.657268704859411 0.933825198637911 0.327586206896552 13.1 13 1 abnormal joint morphology 0.160761605134743 0.658508395550602 0.932931586007636 0.327272727272727 13.1 13 1 abnormal leukocyte migration 0.170702353923499 0.665030705379331 0.931934864227713 0.326923076923077 13.1 13 1 abnormal epidermis stratum corneum morphology 0.181437841743638 0.684485178632931 0.930816094882902 0.326530612244898 13.1 13 1 decreased urine osmolality 0.181437841743638 0.684485178632931 0.930816094882902 0.326530612244898 13.1 13 1 abnormal motor capabilities/coordination/movement 0.0534771756012874 0.351776526619682 0.928612458294638 0.325757575757576 13.1 13 1 abnormal kidney morphology 0.0301307362101244 0.231327797292236 0.928489054645695 0.325714285714286 13.1 13 1 increased circulating creatinine level 0.103475346324066 0.508183462943958 0.928110234141963 0.325581395348837 13.1 13 1 kidney failure 0.205689278023707 0.72953037283792 0.928110234141963 0.325581395348837 13.1 13 1 short tail 0.109233005725651 0.53277863086776 0.927311516212409 0.325301204819277 13.1 13 1 perinatal lethality 0.219452947241161 0.72953037283792 0.926452894438138 0.325 13.1 13 1 abnormal skin pigmentation 0.219452947241161 0.72953037283792 0.926452894438138 0.325 13.1 13 1 increased susceptibility to weight loss 0.219452947241161 0.72953037283792 0.926452894438138 0.325 13.1 13 1 abnormal blood homeostasis 0.0724245233929665 0.395078951622816 0.925202620626481 0.324561403508772 13.1 13 1 abnormal vocalization 0.234518848198365 0.72953037283792 0.924526796944504 0.324324324324324 13.1 13 1 decreased width of hypertrophic chondrocyte zone 0.234518848198365 0.72953037283792 0.924526796944504 0.324324324324324 13.1 13 1 abnormal retinal photoreceptor morphology 0.251092033712912 0.72953037283792 0.922260799893169 0.323529411764706 13.1 13 1 increased susceptibility to weight gain 0.251092033712912 0.72953037283792 0.922260799893169 0.323529411764706 13.1 13 1 osteopetrosis 0.269432146440571 0.731859309429029 0.919556222767383 0.32258064516129 13.1 13 1 abnormal object recognition memory 0.269432146440571 0.731859309429029 0.919556222767383 0.32258064516129 13.1 13 1 abnormal CD8-positive, alpha beta T cell morphology 0.269432146440571 0.731859309429029 0.919556222767383 0.32258064516129 13.1 13 1 abnormal T cell proliferation 0.269432146440571 0.731859309429029 0.919556222767383 0.32258064516129 13.1 13 1 abnormal seminal vesicle morphology 0.182243987591472 0.684485178632931 0.916272093400357 0.321428571428571 13.1 13 1 rib bifurcation 0.28987575705446 0.752678440159677 0.916272093400357 0.321428571428571 13.1 13 1 increased triglyceride level 0.28987575705446 0.752678440159677 0.916272093400357 0.321428571428571 13.1 13 1 corneal vascularization 0.28987575705446 0.752678440159677 0.916272093400357 0.321428571428571 13.1 13 1 abnormal renal tubule epithelium morphology 0.28987575705446 0.752678440159677 0.916272093400357 0.321428571428571 13.1 13 1 increased exploration in new environment 0.129612983575255 0.577921763998859 0.915015204383347 0.320987654320988 13.1 13 1 abnormal coat/ hair morphology 0.193622870727334 0.710378895183248 0.914351187544171 0.320754716981132 13.1 13 1 absent gastric milk in neonates 0.136975140402874 0.603546877944284 0.913661631595797 0.320512820512821 13.1 13 1 kidney inflammation 0.205923297185839 0.72953037283792 0.912199772985244 0.32 13.1 13 1 abnormal thyroid gland morphology 0.312871677678279 0.804466719135886 0.912199772985244 0.32 13.1 13 1 abnormal tibia morphology 0.219255999109358 0.72953037283792 0.909773709759219 0.319148936170213 13.1 13 1 hepatic necrosis 0.219255999109358 0.72953037283792 0.909773709759219 0.319148936170213 13.1 13 1 abnormal coat appearance 0.16218971425191 0.658508395550602 0.908894701343993 0.318840579710145 13.1 13 1 decreased spleen weight 0.16218971425191 0.658508395550602 0.908894701343993 0.318840579710145 13.1 13 1 increased lymphocyte cell number 0.16218971425191 0.658508395550602 0.908894701343993 0.318840579710145 13.1 13 1 osteoporosis 0.233752503589275 0.72953037283792 0.907016819729646 0.318181818181818 13.1 13 1 decreased macrophage cell number 0.233752503589275 0.72953037283792 0.907016819729646 0.318181818181818 13.1 13 1 abnormal amino acid level 0.233752503589275 0.72953037283792 0.907016819729646 0.318181818181818 13.1 13 1 abnormal facial nerve morphology 0.33903952735963 0.856294064142105 0.907016819729646 0.318181818181818 13.1 13 1 decreased cardiac output 0.33903952735963 0.856294064142105 0.907016819729646 0.318181818181818 13.1 13 1 cleft upper lip 0.33903952735963 0.856294064142105 0.907016819729646 0.318181818181818 13.1 13 1 abnormal occipital bone morphology 0.33903952735963 0.856294064142105 0.907016819729646 0.318181818181818 13.1 13 1 rough coat 0.33903952735963 0.856294064142105 0.907016819729646 0.318181818181818 13.1 13 1 impaired humoral immune response 0.33903952735963 0.856294064142105 0.907016819729646 0.318181818181818 13.1 13 1 respiratory distress 0.0502317406970335 0.338621829224582 0.906267838045311 0.317919075144509 13.1 13 1 increased circulating aspartate transaminase level 0.182100416534964 0.684485178632931 0.904960092247266 0.317460317460317 13.1 13 1 decreased cardiac muscle contractility 0.110798013134844 0.535008457391729 0.904525015279839 0.317307692307692 13.1 13 1 scaly skin 0.249570909724748 0.72953037283792 0.903856482378672 0.317073170731707 13.1 13 1 arrested B cell differentiation 0.249570909724748 0.72953037283792 0.903856482378672 0.317073170731707 13.1 13 1 increased tumor growth/size 0.249570909724748 0.72953037283792 0.903856482378672 0.317073170731707 13.1 13 1 palatal shelves fail to meet at midline 0.249570909724748 0.72953037283792 0.903856482378672 0.317073170731707 13.1 13 1 abnormal axial skeleton morphology 0.161887530934094 0.658508395550602 0.900197144393333 0.315789473684211 13.1 13 1 flaky skin 0.369272749839962 0.9041003594753 0.900197144393333 0.315789473684211 13.1 13 1 abnormal stationary movement 0.369272749839962 0.9041003594753 0.900197144393333 0.315789473684211 13.1 13 1 unresponsive to tactile stimuli 0.369272749839962 0.9041003594753 0.900197144393333 0.315789473684211 13.1 13 1 decreased germ cell number 0.369272749839962 0.9041003594753 0.900197144393333 0.315789473684211 13.1 13 1 abnormal digestive system development 0.369272749839962 0.9041003594753 0.900197144393333 0.315789473684211 13.1 13 1 abnormal sternebra morphology 0.369272749839962 0.9041003594753 0.900197144393333 0.315789473684211 13.1 13 1 thin interventricular septum 0.369272749839962 0.9041003594753 0.900197144393333 0.315789473684211 13.1 13 1 neonatal lethality, complete penetrance 0.00402873025196023 0.0529342010960196 0.900197144393333 0.315789473684211 13.1 13 1 abnormal maxilla morphology 0.217931665687504 0.72953037283792 0.897418758145205 0.314814814814815 13.1 13 1 decreased tumor growth/size 0.217931665687504 0.72953037283792 0.897418758145205 0.314814814814815 13.1 13 1 decreased bone volume 0.285989864511492 0.748290426002694 0.895910491324793 0.314285714285714 13.1 13 1 impaired adaptive thermogenesis 0.285989864511492 0.748290426002694 0.895910491324793 0.314285714285714 13.1 13 1 abnormal gluconeogenesis 0.23182159349782 0.72953037283792 0.89431350292671 0.313725490196078 13.1 13 1 abnormal posture 0.170264390094257 0.664731619601176 0.890820090805902 0.3125 13.1 13 1 abnormal kidney physiology 0.24687651470382 0.72953037283792 0.890820090805902 0.3125 13.1 13 1 abnormal osteoclast morphology 0.24687651470382 0.72953037283792 0.890820090805902 0.3125 13.1 13 1 abnormal vertebral body morphology 0.307129590353818 0.794989444334155 0.890820090805902 0.3125 13.1 13 1 abnormal crypts of Lieberkuhn morphology 0.307129590353818 0.794989444334155 0.890820090805902 0.3125 13.1 13 1 abnormal depression-related behavior 0.307129590353818 0.794989444334155 0.890820090805902 0.3125 13.1 13 1 decreased susceptibility to parasitic infection 0.307129590353818 0.794989444334155 0.890820090805902 0.3125 13.1 13 1 absent mandible 0.404933788486796 0.925306671453619 0.890820090805902 0.3125 13.1 13 1 vasculature congestion 0.404933788486796 0.925306671453619 0.890820090805902 0.3125 13.1 13 1 reduced male mating frequency 0.404933788486796 0.925306671453619 0.890820090805902 0.3125 13.1 13 1 abnormal intestinal absorption 0.404933788486796 0.925306671453619 0.890820090805902 0.3125 13.1 13 1 abnormal extraembryonic endoderm formation 0.404933788486796 0.925306671453619 0.890820090805902 0.3125 13.1 13 1 abnormal olfaction 0.404933788486796 0.925306671453619 0.890820090805902 0.3125 13.1 13 1 white spotting 0.404933788486796 0.925306671453619 0.890820090805902 0.3125 13.1 13 1 large intestinal inflammation 0.404933788486796 0.925306671453619 0.890820090805902 0.3125 13.1 13 1 abnormal molar crown morphology 0.404933788486796 0.925306671453619 0.890820090805902 0.3125 13.1 13 1 sepsis 0.404933788486796 0.925306671453619 0.890820090805902 0.3125 13.1 13 1 dystonia 0.404933788486796 0.925306671453619 0.890820090805902 0.3125 13.1 13 1 loose skin 0.404933788486796 0.925306671453619 0.890820090805902 0.3125 13.1 13 1 decreased circulating triiodothyronine level 0.404933788486796 0.925306671453619 0.890820090805902 0.3125 13.1 13 1 abnormal thoracic cage shape 0.404933788486796 0.925306671453619 0.890820090805902 0.3125 13.1 13 1 dilated respiratory conducting tubes 0.404933788486796 0.925306671453619 0.890820090805902 0.3125 13.1 13 1 polyuria 0.179998855282134 0.684485178632931 0.888506272388225 0.311688311688312 13.1 13 1 increased or absent threshold for auditory brainstem response 0.0274277830812672 0.215906994983077 0.887737668346366 0.311418685121107 13.1 13 1 irregular heartbeat 0.263242991653236 0.729844095684676 0.886860890402321 0.311111111111111 13.1 13 1 cochlear ganglion degeneration 0.229179338174941 0.72953037283792 0.884676503972758 0.310344827586207 13.1 13 1 abnormal parietal bone morphology 0.330710461444984 0.84071770346898 0.884676503972758 0.310344827586207 13.1 13 1 abnormal spinal nerve morphology 0.330710461444984 0.84071770346898 0.884676503972758 0.310344827586207 13.1 13 1 decreased retinal photoreceptor cell number 0.330710461444984 0.84071770346898 0.884676503972758 0.310344827586207 13.1 13 1 stomach inflammation 0.330710461444984 0.84071770346898 0.884676503972758 0.310344827586207 13.1 13 1 abnormal outer ear morphology 0.330710461444984 0.84071770346898 0.884676503972758 0.310344827586207 13.1 13 1 hyperactivity 0.0165711485397645 0.149893570882415 0.883616693845208 0.309973045822102 13.1 13 1 atelectasis 0.201490870114071 0.72953037283792 0.8832920337005 0.309859154929577 13.1 13 1 increased anxiety-related response 0.108638437059138 0.530398650018851 0.881847802121526 0.309352517985612 13.1 13 1 abnormal learning/memory/conditioning 0.243507745408475 0.72953037283792 0.881102053451656 0.309090909090909 13.1 13 1 abnormal hair growth 0.258985699975296 0.72953037283792 0.877115166331965 0.307692307692308 13.1 13 1 decreased kidney weight 0.258985699975296 0.72953037283792 0.877115166331965 0.307692307692308 13.1 13 1 abnormal brain wave pattern 0.258985699975296 0.72953037283792 0.877115166331965 0.307692307692308 13.1 13 1 increased susceptibility to injury 0.258985699975296 0.72953037283792 0.877115166331965 0.307692307692308 13.1 13 1 abnormal nasal bone morphology 0.3572446556221 0.880719604420192 0.877115166331965 0.307692307692308 13.1 13 1 small seminal vesicle 0.3572446556221 0.880719604420192 0.877115166331965 0.307692307692308 13.1 13 1 thick skin 0.3572446556221 0.880719604420192 0.877115166331965 0.307692307692308 13.1 13 1 abnormal limb morphology 0.210539998464208 0.72953037283792 0.874191449110859 0.306666666666667 13.1 13 1 postnatal lethality, complete penetrance 0.0233315137632356 0.188738668247312 0.871434368622562 0.305699481865285 13.1 13 1 abnormal uterus morphology 0.322161519167307 0.821503617558867 0.871024088787994 0.305555555555556 13.1 13 1 abnormal epidermis stratum granulosum morphology 0.322161519167307 0.821503617558867 0.871024088787994 0.305555555555556 13.1 13 1 abnormal response/metabolism to endogenous compounds 0.20750714640147 0.72953037283792 0.869092771517954 0.304878048780488 13.1 13 1 increased sensitivity to induced morbidity/mortality 0.0980741536927532 0.485491457334773 0.867581305828357 0.304347826086957 13.1 13 1 abnormal blood vessel physiology 0.387430730804446 0.909671673110222 0.867581305828357 0.304347826086957 13.1 13 1 abnormal B cell morphology 0.387430730804446 0.909671673110222 0.867581305828357 0.304347826086957 13.1 13 1 abnormal corneal stroma morphology 0.387430730804446 0.909671673110222 0.867581305828357 0.304347826086957 13.1 13 1 increased susceptibility to fungal infection 0.387430730804446 0.909671673110222 0.867581305828357 0.304347826086957 13.1 13 1 reduced long term potentiation 0.169874693033204 0.664731619601176 0.865368088211448 0.303571428571429 13.1 13 1 abnormal eye development 0.270212460354348 0.731859309429029 0.865368088211448 0.303571428571429 13.1 13 1 abnormal aorta morphology 0.345960013854398 0.856294064142105 0.863825542599663 0.303030303030303 13.1 13 1 dextrocardia 0.345960013854398 0.856294064142105 0.863825542599663 0.303030303030303 13.1 13 1 decreased circulating phosphate level 0.335447155105887 0.852323593795603 0.855187287173666 0.3 13.1 13 1 abnormal pericardium morphology 0.422258752657547 0.925306671453619 0.855187287173666 0.3 13.1 13 1 abnormal dopamine level 0.422258752657547 0.925306671453619 0.855187287173666 0.3 13.1 13 1 abnormal male reproductive system physiology 0.422258752657547 0.925306671453619 0.855187287173666 0.3 13.1 13 1 kidney atrophy 0.422258752657547 0.925306671453619 0.855187287173666 0.3 13.1 13 1 decreased insulin secretion 0.22333021611465 0.72953037283792 0.855187287173666 0.3 13.1 13 1 emphysema 0.372459105488982 0.909671673110222 0.855187287173666 0.3 13.1 13 1 kidney cysts 0.268008151383062 0.731859309429029 0.847482897199129 0.297297297297297 13.1 13 1 increased brown adipose tissue amount 0.359241110731089 0.883452558520598 0.847482897199129 0.297297297297297 13.1 13 1 impaired skeletal muscle contractility 0.359241110731089 0.883452558520598 0.847482897199129 0.297297297297297 13.1 13 1 increased insulin secretion 0.359241110731089 0.883452558520598 0.847482897199129 0.297297297297297 13.1 13 1 abnormal pancreatic beta cell physiology 0.359241110731089 0.883452558520598 0.847482897199129 0.297297297297297 13.1 13 1 abnormal hair follicle development 0.359241110731089 0.883452558520598 0.847482897199129 0.297297297297297 13.1 13 1 cyanosis 0.137087029563224 0.603546877944284 0.846279086265607 0.296875 13.1 13 1 short snout 0.221764314291585 0.72953037283792 0.844629419430782 0.296296296296296 13.1 13 1 abnormal mandible morphology 0.31643767207246 0.807988530744981 0.844629419430782 0.296296296296296 13.1 13 1 abnormal type II pneumocyte morphology 0.402198698270838 0.925306671453619 0.844629419430782 0.296296296296296 13.1 13 1 abnormal circadian rhythm 0.347329602100923 0.858829408773406 0.842229904034671 0.295454545454545 13.1 13 1 decreased sensitivity to induced morbidity/mortality 0.347329602100923 0.858829408773406 0.842229904034671 0.295454545454545 13.1 13 1 abnormal lung morphology 0.223554102914674 0.72953037283792 0.83841890899379 0.294117647058824 13.1 13 1 abnormal vision 0.385488338913351 0.909671673110222 0.83841890899379 0.294117647058824 13.1 13 1 abnormal nervous system development 0.385488338913351 0.909671673110222 0.83841890899379 0.294117647058824 13.1 13 1 abnormal skin physiology 0.385488338913351 0.909671673110222 0.83841890899379 0.294117647058824 13.1 13 1 increased susceptibility to viral infection induced morbidity/mortality 0.385488338913351 0.909671673110222 0.83841890899379 0.294117647058824 13.1 13 1 distended urinary bladder 0.463201570464987 0.943664133113559 0.83841890899379 0.294117647058824 13.1 13 1 abnormal vagus nerve morphology 0.463201570464987 0.943664133113559 0.83841890899379 0.294117647058824 13.1 13 1 increased aggression towards mice 0.463201570464987 0.943664133113559 0.83841890899379 0.294117647058824 13.1 13 1 abnormal touch/ nociception 0.463201570464987 0.943664133113559 0.83841890899379 0.294117647058824 13.1 13 1 abnormal cranial suture morphology 0.463201570464987 0.943664133113559 0.83841890899379 0.294117647058824 13.1 13 1 abnormal glutamate-mediated receptor currents 0.463201570464987 0.943664133113559 0.83841890899379 0.294117647058824 13.1 13 1 decreased vasoconstriction 0.463201570464987 0.943664133113559 0.83841890899379 0.294117647058824 13.1 13 1 abnormal duodenum morphology 0.463201570464987 0.943664133113559 0.83841890899379 0.294117647058824 13.1 13 1 abnormal tarsal bone morphology 0.463201570464987 0.943664133113559 0.83841890899379 0.294117647058824 13.1 13 1 coloboma 0.463201570464987 0.943664133113559 0.83841890899379 0.294117647058824 13.1 13 1 common atrium 0.463201570464987 0.943664133113559 0.83841890899379 0.294117647058824 13.1 13 1 decreased body fat mass 0.463201570464987 0.943664133113559 0.83841890899379 0.294117647058824 13.1 13 1 abnormal CNS synaptic transmission 0.257528864642594 0.72953037283792 0.835031357846341 0.292929292929293 13.1 13 1 decreased anxiety-related response 0.229558240471111 0.72953037283792 0.834329060657235 0.292682926829268 13.1 13 1 abnormal body weight 0.435900610668018 0.925306671453619 0.831432084752176 0.291666666666667 13.1 13 1 decreased metastatic potential 0.435900610668018 0.925306671453619 0.831432084752176 0.291666666666667 13.1 13 1 abnormal startle reflex 0.435900610668018 0.925306671453619 0.831432084752176 0.291666666666667 13.1 13 1 abnormal impulse conducting system conduction 0.435900610668018 0.925306671453619 0.831432084752176 0.291666666666667 13.1 13 1 abnormal retinal ganglion layer morphology 0.435900610668018 0.925306671453619 0.831432084752176 0.291666666666667 13.1 13 1 abnormal truncus arteriosus septation 0.435900610668018 0.925306671453619 0.831432084752176 0.291666666666667 13.1 13 1 increased circulating glucose level 0.225442826905389 0.72953037283792 0.8289049355584 0.290780141843972 13.1 13 1 decreased neuronal precursor cell number 0.414606497826968 0.925306671453619 0.827600600490645 0.290322580645161 13.1 13 1 abnormal podocyte morphology 0.414606497826968 0.925306671453619 0.827600600490645 0.290322580645161 13.1 13 1 abnormal sternum morphology 0.325671627464052 0.830028866103309 0.826267910312721 0.289855072463768 13.1 13 1 increased grooming behavior 0.396859987134726 0.925306671453619 0.825180715693889 0.289473684210526 13.1 13 1 decreased threshold for auditory brainstem response 0.396859987134726 0.925306671453619 0.825180715693889 0.289473684210526 13.1 13 1 seizures 0.264483237006691 0.729844095684676 0.825180715693888 0.289473684210526 13.1 13 1 albuminuria 0.381489787595296 0.909671673110222 0.823513683945012 0.288888888888889 13.1 13 1 decreased body temperature 0.367842132643094 0.903710918468836 0.822295468436218 0.288461538461538 13.1 13 1 abnormal tail morphology 0.34423141933617 0.856294064142105 0.82063426546968 0.287878787878788 13.1 13 1 short limbs 0.315024602650512 0.807443275727097 0.819144911085887 0.28735632183908 13.1 13 1 abnormal skeleton morphology 0.283437184412401 0.74529597909709 0.818005231209594 0.28695652173913 13.1 13 1 short mandible 0.376815714638506 0.909671673110222 0.814464083022539 0.285714285714286 13.1 13 1 abnormal circulating cholesterol level 0.447127874757389 0.925306671453619 0.814464083022539 0.285714285714286 13.1 13 1 abnormal jaw morphology 0.447127874757389 0.925306671453619 0.814464083022539 0.285714285714286 13.1 13 1 reddish skin 0.447127874757389 0.925306671453619 0.814464083022539 0.285714285714286 13.1 13 1 hypoxia 0.447127874757389 0.925306671453619 0.814464083022539 0.285714285714286 13.1 13 1 organ of Corti degeneration 0.390990212056346 0.917103396973276 0.814464083022539 0.285714285714286 13.1 13 1 abnormal trabecular bone morphology 0.289384980184706 0.752678440159677 0.814464083022539 0.285714285714286 13.1 13 1 abnormal action potential 0.352298700075929 0.86981937115521 0.814464083022539 0.285714285714286 13.1 13 1 abnormal muscle morphology 0.406936478873496 0.925306671453619 0.814464083022539 0.285714285714286 13.1 13 1 spina bifida 0.406936478873496 0.925306671453619 0.814464083022539 0.285714285714286 13.1 13 1 decreased bone mineralization 0.425287728674095 0.925306671453619 0.814464083022539 0.285714285714286 13.1 13 1 abnormal anxiety-related response 0.474561280214626 0.964437242266244 0.814464083022539 0.285714285714286 13.1 13 1 hypoalgesia 0.474561280214626 0.964437242266244 0.814464083022539 0.285714285714286 13.1 13 1 increased acute inflammation 0.474561280214626 0.964437242266244 0.814464083022539 0.285714285714286 13.1 13 1 increased keratinocyte proliferation 0.474561280214626 0.964437242266244 0.814464083022539 0.285714285714286 13.1 13 1 vascular ring 0.474561280214626 0.964437242266244 0.814464083022539 0.285714285714286 13.1 13 1 abnormal vertebrae morphology 0.311021799843918 0.804466719135886 0.810728009247206 0.284403669724771 13.1 13 1 increased liver weight 0.338402239979934 0.856294064142105 0.809836446187184 0.284090909090909 13.1 13 1 abnormal skeleton development 0.348753062968151 0.861920759198486 0.809436526954499 0.283950617283951 13.1 13 1 abnormal T cell activation 0.359882285385622 0.884592079937486 0.808960947326441 0.283783783783784 13.1 13 1 abnormal long bone epiphyseal plate morphology 0.38510263067651 0.909671673110222 0.807676882330685 0.283333333333333 13.1 13 1 abnormal incisor morphology 0.38510263067651 0.909671673110222 0.807676882330685 0.283333333333333 13.1 13 1 acanthosis 0.434657202787256 0.925306671453619 0.804022235804302 0.282051282051282 13.1 13 1 abnormal lens fiber morphology 0.434657202787256 0.925306671453619 0.804022235804302 0.282051282051282 13.1 13 1 abnormal response to injury 0.434657202787256 0.925306671453619 0.804022235804302 0.282051282051282 13.1 13 1 abnormal urine homeostasis 0.351393796706565 0.86801595760435 0.801738081725312 0.28125 13.1 13 1 abnormal primitive streak morphology 0.483745195719583 0.964870939254209 0.798174801362089 0.28 13.1 13 1 abnormal keratinocyte physiology 0.483745195719583 0.964870939254209 0.798174801362089 0.28 13.1 13 1 diaphragmatic hernia 0.483745195719583 0.964870939254209 0.798174801362089 0.28 13.1 13 1 abnormal cochlear outer hair cell morphology 0.483745195719583 0.964870939254209 0.798174801362089 0.28 13.1 13 1 abnormal intestinal mucosa morphology 0.442999864726674 0.925306671453619 0.795523057835969 0.27906976744186 13.1 13 1 impaired macrophage phagocytosis 0.442999864726674 0.925306671453619 0.795523057835969 0.27906976744186 13.1 13 1 abnormal chondrocyte morphology 0.431661024086998 0.925306671453619 0.791840080716358 0.277777777777778 13.1 13 1 abnormal long bone epiphyseal plate proliferative zone 0.431661024086998 0.925306671453619 0.791840080716358 0.277777777777778 13.1 13 1 abnormal mitral valve morphology 0.519611169741473 1 0.791840080716358 0.277777777777778 13.1 13 1 abnormal phrenic nerve morphology 0.519611169741473 1 0.791840080716358 0.277777777777778 13.1 13 1 blepharoptosis 0.519611169741473 1 0.791840080716358 0.277777777777778 13.1 13 1 increased circulating renin level 0.519611169741473 1 0.791840080716358 0.277777777777778 13.1 13 1 abnormal body wall morphology 0.519611169741473 1 0.791840080716358 0.277777777777778 13.1 13 1 abnormal eye anterior chamber morphology 0.519611169741473 1 0.791840080716358 0.277777777777778 13.1 13 1 abnormal sperm axoneme morphology 0.519611169741473 1 0.791840080716358 0.277777777777778 13.1 13 1 impaired leukocyte tethering or rolling 0.519611169741473 1 0.791840080716358 0.277777777777778 13.1 13 1 aphagia 0.491477365543067 0.969124016479096 0.786379114642452 0.275862068965517 13.1 13 1 increased retinal apoptosis 0.491477365543067 0.969124016479096 0.786379114642452 0.275862068965517 13.1 13 1 abnormal epidermal layer morphology 0.428215085918733 0.925306671453619 0.784954514797085 0.27536231884058 13.1 13 1 increased eosinophil cell number 0.444955309376302 0.925306671453619 0.781622789352276 0.274193548387097 13.1 13 1 hydronephrosis 0.424677110311629 0.925306671453619 0.780528079563267 0.273809523809524 13.1 13 1 decreased systemic arterial blood pressure 0.498176178446258 0.981555044661439 0.777442988339697 0.272727272727273 13.1 13 1 decreased sensitivity to xenobiotic induced morbidity/mortality 0.498176178446258 0.981555044661439 0.777442988339697 0.272727272727273 13.1 13 1 deafness 0.421170808105246 0.925306671453619 0.777442988339697 0.272727272727273 13.1 13 1 small kidney 0.430053234746225 0.925306671453619 0.777442988339697 0.272727272727273 13.1 13 1 hypertension 0.47887621321133 0.964870939254209 0.777442988339697 0.272727272727273 13.1 13 1 renal interstitial fibrosis 0.47887621321133 0.964870939254209 0.777442988339697 0.272727272727273 13.1 13 1 increased activated T cell number 0.525381937535249 1 0.777442988339697 0.272727272727273 13.1 13 1 increased coping response 0.525381937535249 1 0.777442988339697 0.272727272727273 13.1 13 1 parakeratosis 0.525381937535249 1 0.777442988339697 0.272727272727273 13.1 13 1 abnormal blood-brain barrier function 0.525381937535249 1 0.777442988339697 0.272727272727273 13.1 13 1 decreased susceptibility to viral infection induced morbidity/mortality 0.525381937535249 1 0.777442988339697 0.272727272727273 13.1 13 1 abnormal cerebral cortex pyramidal cell morphology 0.525381937535249 1 0.777442988339697 0.272727272727273 13.1 13 1 pulmonary vascular congestion 0.525381937535249 1 0.777442988339697 0.272727272727273 13.1 13 1 abnormal intestinal epithelium morphology 0.484859765516806 0.964870939254209 0.772044078698449 0.270833333333333 13.1 13 1 oligodactyly 0.484859765516806 0.964870939254209 0.772044078698449 0.270833333333333 13.1 13 1 decreased circulating chloride level 0.50410370899132 0.982725686611214 0.770438997453753 0.27027027027027 13.1 13 1 abnormal hair follicle morphology 0.474869983985442 0.964670547295865 0.769216078410176 0.26984126984127 13.1 13 1 decreased Peyer's patch number 0.530350657860761 1 0.76747577054047 0.269230769230769 13.1 13 1 altered response to myocardial infarction 0.514289458889888 0.99633569235872 0.760166477487703 0.266666666666667 13.1 13 1 abnormal heart tube morphology 0.534756732835461 1 0.760166477487703 0.266666666666667 13.1 13 1 abnormal lactation 0.534756732835461 1 0.760166477487703 0.266666666666667 13.1 13 1 abnormal immune system physiology 0.469191517096927 0.955475971165458 0.758633883783091 0.266129032258065 13.1 13 1 absent kidney 0.518757104266417 1 0.756288077092358 0.26530612244898 13.1 13 1 decreased pancreatic beta cell number 0.538743800678104 1 0.754577018094411 0.264705882352941 13.1 13 1 decreased regulatory T cell number 0.538743800678104 1 0.754577018094411 0.264705882352941 13.1 13 1 abnormal eye electrophysiology 0.487047179899656 0.964870939254209 0.75388410990516 0.264462809917355 13.1 13 1 abnormal digit morphology 0.512637473217554 0.993522177349955 0.75224807668054 0.263888888888889 13.1 13 1 abnormal spatial learning 0.482244791746952 0.964870939254209 0.752005180950259 0.263803680981595 13.1 13 1 persistence of hyaloid vascular system 0.542405038225818 1 0.750164286994444 0.263157894736842 13.1 13 1 delayed sexual maturation 0.573303462563441 1 0.750164286994444 0.263157894736842 13.1 13 1 abnormal neurotransmitter level 0.573303462563441 1 0.750164286994444 0.263157894736842 13.1 13 1 abnormal nasal septum morphology 0.573303462563441 1 0.750164286994444 0.263157894736842 13.1 13 1 abnormal response to novelty 0.573303462563441 1 0.750164286994444 0.263157894736842 13.1 13 1 maternal imprinting 0.573303462563441 1 0.750164286994444 0.263157894736842 13.1 13 1 increased circulating VLDL cholesterol level 0.573303462563441 1 0.750164286994444 0.263157894736842 13.1 13 1 decreased eye pigmentation 0.573303462563441 1 0.750164286994444 0.263157894736842 13.1 13 1 decreased liver regeneration 0.573303462563441 1 0.750164286994444 0.263157894736842 13.1 13 1 decreased liver glycogen level 0.573303462563441 1 0.750164286994444 0.263157894736842 13.1 13 1 right-sided stomach 0.573303462563441 1 0.750164286994444 0.263157894736842 13.1 13 1 impaired natural killer cell mediated cytotoxicity 0.526776698839141 1 0.750164286994444 0.263157894736842 13.1 13 1 abnormal circulating amino acid level 0.526776698839141 1 0.750164286994444 0.263157894736842 13.1 13 1 abnormal social investigation 0.519905041191304 1 0.748288876276958 0.2625 13.1 13 1 abnormal maternal nurturing 0.53041800156063 1 0.747704731955118 0.262295081967213 13.1 13 1 abnormal optic nerve morphology 0.545804491088223 1 0.746592076103994 0.261904761904762 13.1 13 1 short femur 0.526525432404468 1 0.745049530492209 0.261363636363636 13.1 13 1 abnormal food intake 0.537121657872414 1 0.743641119281449 0.260869565217391 13.1 13 1 fragile skeleton 0.574070598734356 1 0.743641119281449 0.260869565217391 13.1 13 1 abnormal innervation pattern to muscle 0.574070598734356 1 0.743641119281449 0.260869565217391 13.1 13 1 abnormal circulating insulin level 0.574070598734356 1 0.743641119281449 0.260869565217391 13.1 13 1 abnormal cochlear ganglion morphology 0.574070598734356 1 0.743641119281449 0.260869565217391 13.1 13 1 delayed wound healing 0.548988190074116 1 0.743641119281449 0.260869565217391 13.1 13 1 increased susceptibility to age related obesity 0.574070598734356 1 0.743641119281449 0.260869565217391 13.1 13 1 abnormal palatal shelf fusion at midline 0.574070598734356 1 0.743641119281449 0.260869565217391 13.1 13 1 abnormal hepatocyte physiology 0.574070598734356 1 0.743641119281449 0.260869565217391 13.1 13 1 abnormal digestive system physiology 0.551990410816311 1 0.741162315550511 0.26 13.1 13 1 abnormal axon extension 0.551990410816311 1 0.741162315550511 0.26 13.1 13 1 rectal prolapse 0.575203843717233 1 0.739050742001934 0.259259259259259 13.1 13 1 abnormal trigeminal nerve morphology 0.575203843717233 1 0.739050742001934 0.259259259259259 13.1 13 1 polyphagia 0.554837420393467 1 0.739050742001934 0.259259259259259 13.1 13 1 abnormal palate morphology 0.575203843717233 1 0.739050742001934 0.259259259259259 13.1 13 1 abnormal nose morphology 0.576548118925372 1 0.735644978213907 0.258064516129032 13.1 13 1 abnormal retinal photoreceptor layer morphology 0.576548118925372 1 0.735644978213907 0.258064516129032 13.1 13 1 decreased susceptibility to bacterial infection induced morbidity/mortality 0.576548118925372 1 0.735644978213907 0.258064516129032 13.1 13 1 abnormal heart looping 0.579559464239116 1 0.730929305276638 0.256410256410256 13.1 13 1 small lens 0.579559464239116 1 0.730929305276638 0.256410256410256 13.1 13 1 abnormal excitatory postsynaptic potential 0.571743299567672 1 0.730037928075081 0.25609756097561 13.1 13 1 abnormal organ of Corti morphology 0.581143581400005 1 0.729229469682971 0.255813953488372 13.1 13 1 abnormal T-helper 1 physiology 0.582749022803844 1 0.727818967807376 0.25531914893617 13.1 13 1 abnormal thrombosis 0.584362375510227 1 0.726629721127952 0.254901960784314 13.1 13 1 abnormal thoracic vertebrae morphology 0.587579797017065 1 0.724734989130226 0.254237288135593 13.1 13 1 abnormal stria vascularis morphology 0.617895833370515 1 0.712656072644722 0.25 13.1 13 1 abnormal systemic arterial blood pressure 0.615705523359908 1 0.712656072644722 0.25 13.1 13 1 abnormal digestive system morphology 0.620127261423135 1 0.712656072644722 0.25 13.1 13 1 kidney cortex cysts 0.616509932229791 1 0.712656072644722 0.25 13.1 13 1 increased circulating luteinizing hormone level 0.617895833370515 1 0.712656072644722 0.25 13.1 13 1 abnormal respiration 0.617895833370515 1 0.712656072644722 0.25 13.1 13 1 apnea 0.620127261423135 1 0.712656072644722 0.25 13.1 13 1 abnormal limb bone morphology 0.615705523359908 1 0.712656072644722 0.25 13.1 13 1 absent corpus callosum 0.617895833370515 1 0.712656072644722 0.25 13.1 13 1 small lymph nodes 0.620127261423135 1 0.712656072644722 0.25 13.1 13 1 abnormal lymph node morphology 0.615378775232856 1 0.712656072644722 0.25 13.1 13 1 abnormal spleen germinal center morphology 0.617895833370515 1 0.712656072644722 0.25 13.1 13 1 straub tail 0.617895833370515 1 0.712656072644722 0.25 13.1 13 1 enhanced coordination 0.617895833370515 1 0.712656072644722 0.25 13.1 13 1 abnormal hormone level 0.617895833370515 1 0.712656072644722 0.25 13.1 13 1 short radius 0.615705523359908 1 0.712656072644722 0.25 13.1 13 1 cochlear outer hair cell degeneration 0.61887726408713 1 0.712656072644722 0.25 13.1 13 1 hypopigmentation 0.620127261423135 1 0.712656072644722 0.25 13.1 13 1 abnormal neuron differentiation 0.628102353093242 1 0.712656072644722 0.25 13.1 13 1 abnormal lung saccule morphology 0.620127261423135 1 0.712656072644722 0.25 13.1 13 1 abnormal skin condition 0.615700949171798 1 0.712656072644722 0.25 13.1 13 1 brain inflammation 0.623651699198739 1 0.712656072644722 0.25 13.1 13 1 decreased inflammatory response 0.621441928818218 1 0.712656072644722 0.25 13.1 13 1 anencephaly 0.623651699198739 1 0.712656072644722 0.25 13.1 13 1 abnormal Peyer's patch T cell area morphology 0.623651699198739 1 0.712656072644722 0.25 13.1 13 1 abnormal hyoid bone morphology 0.623651699198739 1 0.712656072644722 0.25 13.1 13 1 abnormal eye physiology 0.616727045124888 1 0.712656072644722 0.25 13.1 13 1 abnormal response to tactile stimuli 0.623651699198739 1 0.712656072644722 0.25 13.1 13 1 nuclear cataracts 0.623651699198739 1 0.712656072644722 0.25 13.1 13 1 abnormal heart electrocardiography waveform feature 0.623651699198739 1 0.712656072644722 0.25 13.1 13 1 abnormal renal glomerulus morphology 0.648124920166411 1 0.706117943537889 0.247706422018349 13.1 13 1 abnormal pancreatic islet morphology 0.645860347935764 1 0.699209731651425 0.245283018867925 13.1 13 1 abnormal long bone hypertrophic chondrocyte zone 0.646715533384135 1 0.698112071162177 0.244897959183673 13.1 13 1 abnormal craniofacial development 0.646715533384135 1 0.698112071162177 0.244897959183673 13.1 13 1 cleft secondary palate 0.668147390160166 1 0.697493177482068 0.24468085106383 13.1 13 1 abnormal autopod morphology 0.647890812883576 1 0.696819271030395 0.244444444444444 13.1 13 1 decreased osteoclast cell number 0.647890812883576 1 0.696819271030395 0.244444444444444 13.1 13 1 short humerus 0.649471941992449 1 0.695274217214363 0.24390243902439 13.1 13 1 abnormal humerus morphology 0.651577535121241 1 0.693395097708378 0.243243243243243 13.1 13 1 single kidney 0.654376733440521 1 0.69106043407973 0.242424242424242 13.1 13 1 diarrhea 0.654376733440521 1 0.69106043407973 0.242424242424242 13.1 13 1 increased susceptibility to induced arthritis 0.658119891315612 1 0.688081725312145 0.241379310344828 13.1 13 1 increased double-positive T cell number 0.658119891315612 1 0.688081725312145 0.241379310344828 13.1 13 1 abnormal osteoblast physiology 0.674721276180883 1 0.68626140328751 0.240740740740741 13.1 13 1 abnormal nest building behavior 0.663195282171625 1 0.684149829738933 0.24 13.1 13 1 abnormal feces composition 0.663195282171625 1 0.684149829738933 0.24 13.1 13 1 decreased placenta weight 0.663195282171625 1 0.684149829738933 0.24 13.1 13 1 decreased acute inflammation 0.663195282171625 1 0.684149829738933 0.24 13.1 13 1 abnormal salivary gland morphology 0.670242455131274 1 0.678720069185449 0.238095238095238 13.1 13 1 abnormal vibrissa morphology 0.68186802040002 1 0.678720069185449 0.238095238095238 13.1 13 1 decreased cochlear outer hair cell number 0.670242455131274 1 0.678720069185449 0.238095238095238 13.1 13 1 abnormal clavicle morphology 0.670242455131274 1 0.678720069185449 0.238095238095238 13.1 13 1 decreased vocalization 0.670242455131274 1 0.678720069185449 0.238095238095238 13.1 13 1 abnormal frontal bone morphology 0.685458654847407 1 0.675147858295 0.236842105263158 13.1 13 1 impaired branching involved in ureteric bud morphogenesis 0.685458654847407 1 0.675147858295 0.236842105263158 13.1 13 1 abnormal cued conditioning behavior 0.705018377515045 1 0.670735127195032 0.235294117647059 13.1 13 1 decreased osteoblast cell number 0.68995609736742 1 0.670735127195032 0.235294117647059 13.1 13 1 decreased susceptibility to injury 0.720022930539615 1 0.670735127195032 0.235294117647059 13.1 13 1 pulmonary hypoplasia 0.708376721751186 1 0.667167387156761 0.234042553191489 13.1 13 1 increased susceptibility to parasitic infection 0.752099917791786 1 0.66514566780174 0.233333333333333 13.1 13 1 abnormal kidney development 0.725080500670147 1 0.66514566780174 0.233333333333333 13.1 13 1 delayed eyelid opening 0.695665200418266 1 0.66514566780174 0.233333333333333 13.1 13 1 enhanced paired-pulse facilitation 0.695665200418266 1 0.66514566780174 0.233333333333333 13.1 13 1 abnormal xiphoid process morphology 0.703048669464885 1 0.657836374748974 0.230769230769231 13.1 13 1 abnormal stomach morphology 0.703048669464885 1 0.657836374748974 0.230769230769231 13.1 13 1 no spontaneous movement 0.703048669464885 1 0.657836374748974 0.230769230769231 13.1 13 1 abnormal tectorial membrane morphology 0.703048669464885 1 0.657836374748974 0.230769230769231 13.1 13 1 dehydration 0.7643435679311 1 0.651571266418031 0.228571428571429 13.1 13 1 decreased susceptibility to induced arthritis 0.752704055087558 1 0.650142382061851 0.228070175438596 13.1 13 1 abnormal basisphenoid bone morphology 0.71284848971834 1 0.647869156949747 0.227272727272727 13.1 13 1 increased body size 0.71284848971834 1 0.647869156949747 0.227272727272727 13.1 13 1 abnormal retinal layer morphology 0.71284848971834 1 0.647869156949747 0.227272727272727 13.1 13 1 abnormal photoreceptor outer segment morphology 0.740966422832513 1 0.647869156949747 0.227272727272727 13.1 13 1 abnormal retinal outer plexiform layer morphology 0.71284848971834 1 0.647869156949747 0.227272727272727 13.1 13 1 abnormal limb posture 0.71284848971834 1 0.647869156949747 0.227272727272727 13.1 13 1 abnormal basement membrane morphology 0.71284848971834 1 0.647869156949747 0.227272727272727 13.1 13 1 decreased circulating estradiol level 0.71284848971834 1 0.647869156949747 0.227272727272727 13.1 13 1 failure of palatal shelf elevation 0.71284848971834 1 0.647869156949747 0.227272727272727 13.1 13 1 increased circulating creatine kinase level 0.71284848971834 1 0.647869156949747 0.227272727272727 13.1 13 1 abnormal trigeminal ganglion morphology 0.739575762535643 1 0.633472064573086 0.222222222222222 13.1 13 1 increased circulating corticosterone level 0.767559454246494 1 0.633472064573086 0.222222222222222 13.1 13 1 impaired wound healing 0.753813991272658 1 0.633472064573086 0.222222222222222 13.1 13 1 decreased susceptibility to pharmacologically induced seizures 0.739575762535643 1 0.633472064573086 0.222222222222222 13.1 13 1 renal hypoplasia 0.753813991272658 1 0.633472064573086 0.222222222222222 13.1 13 1 decreased bone ossification 0.739575762535643 1 0.633472064573086 0.222222222222222 13.1 13 1 abnormal colon morphology 0.797125633348938 1 0.628103657246196 0.220338983050847 13.1 13 1 syndactyly 0.797125633348938 1 0.628103657246196 0.220338983050847 13.1 13 1 increased dopamine level 0.762299052601719 1 0.623574063564132 0.21875 13.1 13 1 abnormal diaphragm morphology 0.762299052601719 1 0.623574063564132 0.21875 13.1 13 1 abnormal cranial nerve morphology 0.751397903880558 1 0.619700932734541 0.217391304347826 13.1 13 1 abnormal sleep pattern 0.792166387554416 1 0.619700932734541 0.217391304347826 13.1 13 1 abnormal ulna morphology 0.751397903880558 1 0.619700932734541 0.217391304347826 13.1 13 1 abnormal chondrocyte physiology 0.751397903880558 1 0.619700932734541 0.217391304347826 13.1 13 1 cochlear inner hair cell degeneration 0.808170414687592 1 0.614840533262113 0.215686274509804 13.1 13 1 myoclonus 0.772761197762496 1 0.610848062266905 0.214285714285714 13.1 13 1 abnormal cartilage morphology 0.799373449955149 1 0.610848062266904 0.214285714285714 13.1 13 1 abnormal nervous system electrophysiology 0.859712251320936 1 0.610848062266904 0.214285714285714 13.1 13 1 absent vibrissae 0.791355061606657 1 0.604677879819764 0.212121212121212 13.1 13 1 increased percent body fat/body weight 0.828656387745282 1 0.603016676853226 0.211538461538462 13.1 13 1 impaired righting response 0.889185938802678 1 0.600131429595555 0.210526315789474 13.1 13 1 abnormal blood circulation 0.822398327912255 1 0.596642293376976 0.209302325581395 13.1 13 1 abnormal femur morphology 0.862805843180444 1 0.595652836837379 0.208955223880597 13.1 13 1 abnormal sensory capabilities/reflexes/nociception 0.785942809790407 1 0.593880060537268 0.208333333333333 13.1 13 1 increased susceptibility to pharmacologically induced seizures 0.899603176273676 1 0.593880060537268 0.208333333333333 13.1 13 1 abnormal middle ear morphology 0.802667625531249 1 0.589784335981839 0.206896551724138 13.1 13 1 absent long term depression 0.802667625531249 1 0.589784335981839 0.206896551724138 13.1 13 1 overexpanded pulmonary alveoli 0.817643681964978 1 0.586893236295653 0.205882352941176 13.1 13 1 abnormal bone remodeling 0.817643681964978 1 0.586893236295653 0.205882352941176 13.1 13 1 abnormal excitatory postsynaptic currents 0.892981345129801 1 0.58474344422131 0.205128205128205 13.1 13 1 increased vascular permeability 0.831130644577683 1 0.58474344422131 0.205128205128205 13.1 13 1 cochlear hair cell degeneration 0.843337960647045 1 0.583082241254772 0.204545454545455 13.1 13 1 abnormal cartilage development 0.862282587247183 1 0.570124858115778 0.2 13.1 13 1 abnormal hair cycle 0.829418231809494 1 0.570124858115778 0.2 13.1 13 1 abnormal hindlimb morphology 0.871563409297014 1 0.570124858115778 0.2 13.1 13 1 circling 0.919574007722808 1 0.570124858115778 0.2 13.1 13 1 abnormal estrous cycle 0.829418231809494 1 0.570124858115778 0.2 13.1 13 1 abnormal pain threshold 0.829418231809494 1 0.570124858115778 0.2 13.1 13 1 abnormal vertebrae development 0.816629691695102 1 0.570124858115778 0.2 13.1 13 1 abnormal energy expenditure 0.816629691695102 1 0.570124858115778 0.2 13.1 13 1 abnormal inner ear morphology 0.879337879064343 1 0.557730839461087 0.195652173913043 13.1 13 1 abnormal forelimb morphology 0.879337879064343 1 0.557730839461087 0.195652173913043 13.1 13 1 abnormal body temperature homeostasis 0.853180763638887 1 0.55173373366043 0.193548387096774 13.1 13 1 abnormal intestine physiology 0.853180763638887 1 0.55173373366043 0.193548387096774 13.1 13 1 abnormal kidney cortex morphology 0.843672792226106 1 0.548196978957478 0.192307692307692 13.1 13 1 abnormal ureter morphology 0.843672792226106 1 0.548196978957478 0.192307692307692 13.1 13 1 increased systemic arterial blood pressure 0.894620266511366 1 0.545864225855532 0.191489361702128 13.1 13 1 abnormal lymphatic vessel morphology 0.874153466185925 1 0.534492054483541 0.1875 13.1 13 1 abnormal hair shaft morphology 0.908252837689462 1 0.534492054483541 0.1875 13.1 13 1 abnormal cochlea morphology 0.924453505154528 1 0.527893387144239 0.185185185185185 13.1 13 1 wrinkled skin 0.867331208064847 1 0.527893387144239 0.185185185185185 13.1 13 1 decreased circulating progesterone level 0.887889905956663 1 0.509040051889087 0.178571428571429 13.1 13 1 short maxilla 0.908605132294344 1 0.503051345396274 0.176470588235294 13.1 13 1 increased width of hypertrophic chondrocyte zone 0.908605132294344 1 0.503051345396274 0.176470588235294 13.1 13 1 increased kidney weight 0.940512649411714 1 0.503051345396274 0.176470588235294 13.1 13 1 decreased IgA level 0.948798974115272 1 0.493377281061731 0.173076923076923 13.1 13 1 abnormal innervation 0.947089093346216 1 0.485212645204917 0.170212765957447 13.1 13 1 abnormal cardiovascular system morphology 0.954856344477567 1 0.475104048429815 0.166666666666667 13.1 13 1 head tilt 0.934565947000894 1 0.475104048429815 0.166666666666667 13.1 13 1 abnormal phalanx morphology 0.954856344477567 1 0.475104048429815 0.166666666666667 13.1 13 1 abnormal axon guidance 0.954028253241483 1 0.464055117070982 0.162790697674419 13.1 13 1 abnormal inhibitory postsynaptic currents 0.980625610981338 1 0.461130399946585 0.161764705882353 13.1 13 1 enhanced long term potentiation 0.972611653356594 1 0.458136046700178 0.160714285714286 13.1 13 1 abnormal long term potentiation 0.9449769510241 1 0.445410045402951 0.15625 13.1 13 1 impaired swimming 0.987960289907079 1 0.431912771299831 0.151515151515152 13.1 13 1 abnormal middle ear ossicle morphology 0.954338350912691 1 0.431912771299831 0.151515151515152 13.1 13 1 short ulna 0.973123352785443 1 0.417164530328618 0.146341463414634 13.1 13 1 impaired behavioral response to xenobiotic 0.968837994485148 1 0.40723204151127 0.142857142857143 13.1 13 1 delayed intramembranous bone ossification 2.15954485860002e-05 0.000284979726035414 1.0462030279269 1 14.3 14 3 abnormal trophectoderm morphology 2.15954485860002e-05 0.000284979726035414 1.0462030279269 1 14.3 14 3 heterochrony 2.15954485860002e-05 0.000284979726035414 1.0462030279269 1 14.3 14 3 increased hemangioma incidence 4.42077670722166e-05 0.000531240679189077 1.0462030279269 1 14.3 14 3 absent olfactory bulb 4.42077670722166e-05 0.000531240679189077 1.0462030279269 1 14.3 14 3 split sternum 4.42077670722166e-05 0.000531240679189077 1.0462030279269 1 14.3 14 3 decreased tongue size 4.42077670722166e-05 0.000531240679189077 1.0462030279269 1 14.3 14 3 axonal dystrophy 9.04943612933683e-05 0.00100293799144414 1.0462030279269 1 14.3 14 3 absent ovary 0.000185238412517698 0.00187309167129176 1.0462030279269 1 14.3 14 3 increased osteosarcoma incidence 0.000185238412517698 0.00187309167129176 1.0462030279269 1 14.3 14 3 pale placenta 0.000185238412517698 0.00187309167129176 1.0462030279269 1 14.3 14 3 decreased red blood cell distribution width 0.000185238412517698 0.00187309167129176 1.0462030279269 1 14.3 14 3 embryonic lethality between implantation and placentation, incomplete penetrance 0.000185238412517698 0.00187309167129176 1.0462030279269 1 14.3 14 3 delayed hepatic development 0.00037916406830714 0.00346753904380151 1.0462030279269 1 14.3 14 3 abnormal glossopharyngeal ganglion morphology 0.00037916406830714 0.00346753904380151 1.0462030279269 1 14.3 14 3 abnormal proximal-distal axis patterning 0.00037916406830714 0.00346753904380151 1.0462030279269 1 14.3 14 3 abnormal dorsal-ventral polarity of the somites 0.00037916406830714 0.00346753904380151 1.0462030279269 1 14.3 14 3 reduced sympathetic cervical ganglion size 0.00037916406830714 0.00346753904380151 1.0462030279269 1 14.3 14 3 rhinitis 0.000776086077166295 0.00624761850146006 1.0462030279269 1 14.3 14 3 increased heart rate variability 0.000776086077166295 0.00624761850146006 1.0462030279269 1 14.3 14 3 abnormal plasma membrane morphology 0.000776086077166295 0.00624761850146006 1.0462030279269 1 14.3 14 3 abnormal corneal endothelium morphology 0.000776086077166295 0.00624761850146006 1.0462030279269 1 14.3 14 3 increased susceptibility to atherosclerosis 0.000776086077166295 0.00624761850146006 1.0462030279269 1 14.3 14 3 protruding tongue 0.000776086077166295 0.00624761850146006 1.0462030279269 1 14.3 14 3 acanthocytosis 0.000776086077166295 0.00624761850146006 1.0462030279269 1 14.3 14 3 synostosis 0.00158847068841852 0.0113218362104329 1.0462030279269 1 14.3 14 3 abnormal NMDA-mediated synaptic currents 0.00158847068841852 0.0113218362104329 1.0462030279269 1 14.3 14 3 decreased cellular sensitivity to ionizing radiation 0.00158847068841852 0.0113218362104329 1.0462030279269 1 14.3 14 3 increased neuronal precursor cell number 0.00158847068841852 0.0113218362104329 1.0462030279269 1 14.3 14 3 enhanced conditioned place preference behavior 0.00158847068841852 0.0113218362104329 1.0462030279269 1 14.3 14 3 abnormal optic chiasm morphology 0.00158847068841852 0.0113218362104329 1.0462030279269 1 14.3 14 3 abnormal telomere morphology 0.00158847068841852 0.0113218362104329 1.0462030279269 1 14.3 14 3 decreased effector memory CD4-positive, alpha-beta T cell number 0.00158847068841852 0.0113218362104329 1.0462030279269 1 14.3 14 3 abnormal lung lobe morphology 0.00158847068841852 0.0113218362104329 1.0462030279269 1 14.3 14 3 abnormal vagus ganglion morphology 0.00325113583177857 0.020218000953873 1.0462030279269 1 14.3 14 3 colon polyps 0.00325113583177857 0.020218000953873 1.0462030279269 1 14.3 14 3 elevated level of mitotic sister chromatid exchange 0.00325113583177857 0.020218000953873 1.0462030279269 1 14.3 14 3 long femur 0.00325113583177857 0.020218000953873 1.0462030279269 1 14.3 14 3 small frontal bone 0.00325113583177857 0.020218000953873 1.0462030279269 1 14.3 14 3 absent interparietal bone 0.00325113583177857 0.020218000953873 1.0462030279269 1 14.3 14 3 accumulation of giant lysosomes in kidney/renal tubule cells 0.00325113583177857 0.020218000953873 1.0462030279269 1 14.3 14 3 craniofacial phenotype 0.00325113583177857 0.020218000953873 1.0462030279269 1 14.3 14 3 abnormal meiotic spindle morphology 0.00325113583177857 0.020218000953873 1.0462030279269 1 14.3 14 3 abnormal base-excision repair 0.00325113583177857 0.020218000953873 1.0462030279269 1 14.3 14 3 abnormal cerebellum deep nucleus morphology 0.00325113583177857 0.020218000953873 1.0462030279269 1 14.3 14 3 pleural effusion 0.00325113583177857 0.020218000953873 1.0462030279269 1 14.3 14 3 abnormal hepatic vein morphology 0.00325113583177857 0.020218000953873 1.0462030279269 1 14.3 14 3 sinoatrial block 0.00325113583177857 0.020218000953873 1.0462030279269 1 14.3 14 3 impaired mucociliary clearance 0.00325113583177857 0.020218000953873 1.0462030279269 1 14.3 14 3 lung situs inversus 0.00325113583177857 0.020218000953873 1.0462030279269 1 14.3 14 3 abnormal foramen magnum morphology 0.00325113583177857 0.020218000953873 1.0462030279269 1 14.3 14 3 prolonged PQ interval 0.00325113583177857 0.020218000953873 1.0462030279269 1 14.3 14 3 increased mammary gland apoptosis 0.00325113583177857 0.020218000953873 1.0462030279269 1 14.3 14 3 increased brain apoptosis 0.00325113583177857 0.020218000953873 1.0462030279269 1 14.3 14 3 broad head 0.00665392071001892 0.0373625908942936 1.0462030279269 1 14.3 14 3 maxilla hypoplasia 0.00665392071001892 0.0373625908942936 1.0462030279269 1 14.3 14 3 skin photosensitivity 0.00665392071001892 0.0373625908942936 1.0462030279269 1 14.3 14 3 absent epidermis stratum corneum 0.00665392071001892 0.0373625908942936 1.0462030279269 1 14.3 14 3 abnormal tumor incidence 0.00665392071001892 0.0373625908942936 1.0462030279269 1 14.3 14 3 decreased cardiomyocyte apoptosis 0.00665392071001892 0.0373625908942936 1.0462030279269 1 14.3 14 3 aorta coarctation 0.00665392071001892 0.0373625908942936 1.0462030279269 1 14.3 14 3 increased cell nucleus count 0.00665392071001892 0.0373625908942936 1.0462030279269 1 14.3 14 3 postaxial polydactyly 0.00665392071001892 0.0373625908942936 1.0462030279269 1 14.3 14 3 decreased DN2 thymocyte number 0.00665392071001892 0.0373625908942936 1.0462030279269 1 14.3 14 3 increased oligodendrocyte number 0.00665392071001892 0.0373625908942936 1.0462030279269 1 14.3 14 3 decreased brain cholesterol level 0.00665392071001892 0.0373625908942936 1.0462030279269 1 14.3 14 3 coronary fistula 0.00665392071001892 0.0373625908942936 1.0462030279269 1 14.3 14 3 small lung lobe 0.00665392071001892 0.0373625908942936 1.0462030279269 1 14.3 14 3 abnormal outer hair cell kinocilium morphology 0.00665392071001892 0.0373625908942936 1.0462030279269 1 14.3 14 3 arrest of tooth development 0.0136177929549521 0.0648311195702267 1.0462030279269 1 14.3 14 3 echinocytosis 0.0136177929549521 0.0648311195702267 1.0462030279269 1 14.3 14 3 abnormal lens induction 0.0136177929549521 0.0648311195702267 1.0462030279269 1 14.3 14 3 increased embryo size 0.0136177929549521 0.0648311195702267 1.0462030279269 1 14.3 14 3 absent ectoplacental cone 0.0136177929549521 0.0648311195702267 1.0462030279269 1 14.3 14 3 delayed brain development 0.0136177929549521 0.0648311195702267 1.0462030279269 1 14.3 14 3 reduced NMDA-mediated synaptic currents 0.0136177929549521 0.0648311195702267 1.0462030279269 1 14.3 14 3 abnormal gustatory system physiology 0.0136177929549521 0.0648311195702267 1.0462030279269 1 14.3 14 3 abnormal gland physiology 0.0136177929549521 0.0648311195702267 1.0462030279269 1 14.3 14 3 abnormal hippocampal fimbria morphology 0.0136177929549521 0.0648311195702267 1.0462030279269 1 14.3 14 3 esophageal atresia 0.0136177929549521 0.0648311195702267 1.0462030279269 1 14.3 14 3 decreased liver function 0.0136177929549521 0.0648311195702267 1.0462030279269 1 14.3 14 3 increased glycerol level 0.0136177929549521 0.0648311195702267 1.0462030279269 1 14.3 14 3 abnormal leukocyte tethering or rolling 0.0136177929549521 0.0648311195702267 1.0462030279269 1 14.3 14 3 absent parietal bone 0.0136177929549521 0.0648311195702267 1.0462030279269 1 14.3 14 3 abnormal blastocoele morphology 0.0136177929549521 0.0648311195702267 1.0462030279269 1 14.3 14 3 decreased platelet ADP level 0.0136177929549521 0.0648311195702267 1.0462030279269 1 14.3 14 3 delayed chorioallantoic fusion 0.0136177929549521 0.0648311195702267 1.0462030279269 1 14.3 14 3 absent sperm mitochondrial sheath 0.0136177929549521 0.0648311195702267 1.0462030279269 1 14.3 14 3 abnormal aorta tunica adventitia morphology 0.0136177929549521 0.0648311195702267 1.0462030279269 1 14.3 14 3 myocardium hypoplasia 0.0136177929549521 0.0648311195702267 1.0462030279269 1 14.3 14 3 thick myocardium 0.0136177929549521 0.0648311195702267 1.0462030279269 1 14.3 14 3 podocyte hypertrophy 0.0136177929549521 0.0648311195702267 1.0462030279269 1 14.3 14 3 abnormal endocrine pancreas development 0.0136177929549521 0.0648311195702267 1.0462030279269 1 14.3 14 3 increased total retina thickness 0.0136177929549521 0.0648311195702267 1.0462030279269 1 14.3 14 3 abnormal vertebral artery origin 0.0136177929549521 0.0648311195702267 1.0462030279269 1 14.3 14 3 increased male germ cell apoptosis 0.0136177929549521 0.0648311195702267 1.0462030279269 1 14.3 14 3 abnormal platelet alpha-granule morphology 0.0136177929549521 0.0648311195702267 1.0462030279269 1 14.3 14 3 ectopic bone 0.0136177929549521 0.0648311195702267 1.0462030279269 1 14.3 14 3 decreased hippocampus volume 0.0136177929549521 0.0648311195702267 1.0462030279269 1 14.3 14 3 absent neurocranium 0.0278690671677942 0.110394345353221 1.0462030279269 1 14.3 14 3 abnormal tooth eruption 0.0278690671677942 0.110394345353221 1.0462030279269 1 14.3 14 3 small hair follicles 0.0278690671677942 0.110394345353221 1.0462030279269 1 14.3 14 3 abnormal pineal gland morphology 0.0278690671677942 0.110394345353221 1.0462030279269 1 14.3 14 3 optic nerve atrophy 0.0278690671677942 0.110394345353221 1.0462030279269 1 14.3 14 3 skin hyperplasia 0.0278690671677942 0.110394345353221 1.0462030279269 1 14.3 14 3 kinked vibrissae 0.0278690671677942 0.110394345353221 1.0462030279269 1 14.3 14 3 sinus inflammation 0.0278690671677942 0.110394345353221 1.0462030279269 1 14.3 14 3 abnormal respiratory sounds 0.0278690671677942 0.110394345353221 1.0462030279269 1 14.3 14 3 increased hepatic hemangioma incidence 0.0278690671677942 0.110394345353221 1.0462030279269 1 14.3 14 3 abnormal oropharynx morphology 0.0278690671677942 0.110394345353221 1.0462030279269 1 14.3 14 3 decreased lysosomal enzyme secretion 0.0278690671677942 0.110394345353221 1.0462030279269 1 14.3 14 3 increased lysosomal enzyme secretion 0.0278690671677942 0.110394345353221 1.0462030279269 1 14.3 14 3 enhanced NMDA-mediated synaptic currents 0.0278690671677942 0.110394345353221 1.0462030279269 1 14.3 14 3 ischuria 0.0278690671677942 0.110394345353221 1.0462030279269 1 14.3 14 3 abnormal response to vitamins 0.0278690671677942 0.110394345353221 1.0462030279269 1 14.3 14 3 increased allantois apoptosis 0.0278690671677942 0.110394345353221 1.0462030279269 1 14.3 14 3 increased heart right ventricle weight 0.0278690671677942 0.110394345353221 1.0462030279269 1 14.3 14 3 absent frontal bone 0.0278690671677942 0.110394345353221 1.0462030279269 1 14.3 14 3 abnormal inner cell mass proliferation 0.0278690671677942 0.110394345353221 1.0462030279269 1 14.3 14 3 delayed fertilization 0.0278690671677942 0.110394345353221 1.0462030279269 1 14.3 14 3 corneal deposits 0.0278690671677942 0.110394345353221 1.0462030279269 1 14.3 14 3 abnormal hemoglobin content 0.0278690671677942 0.110394345353221 1.0462030279269 1 14.3 14 3 increased placenta apoptosis 0.0278690671677942 0.110394345353221 1.0462030279269 1 14.3 14 3 absent optic chiasm 0.0278690671677942 0.110394345353221 1.0462030279269 1 14.3 14 3 abnormal mismatch repair 0.0278690671677942 0.110394345353221 1.0462030279269 1 14.3 14 3 abnormal arcus anterior morphology 0.0278690671677942 0.110394345353221 1.0462030279269 1 14.3 14 3 decreased DN3 thymocyte number 0.0278690671677942 0.110394345353221 1.0462030279269 1 14.3 14 3 hemolysis 0.0278690671677942 0.110394345353221 1.0462030279269 1 14.3 14 3 increased response to stress-induced hyperthermia 0.0278690671677942 0.110394345353221 1.0462030279269 1 14.3 14 3 increased T follicular helper cell number 0.0278690671677942 0.110394345353221 1.0462030279269 1 14.3 14 3 increased renal carcinoma incidence 0.0278690671677942 0.110394345353221 1.0462030279269 1 14.3 14 3 calcified aorta 0.0278690671677942 0.110394345353221 1.0462030279269 1 14.3 14 3 aorta hypoplasia 0.0278690671677942 0.110394345353221 1.0462030279269 1 14.3 14 3 abnormal paranode morphology 0.0278690671677942 0.110394345353221 1.0462030279269 1 14.3 14 3 abnormal nephrogenic mesenchyme morphogenesis 0.0278690671677942 0.110394345353221 1.0462030279269 1 14.3 14 3 abnormal circadian regulation of systemic arterial blood pressure 0.0278690671677942 0.110394345353221 1.0462030279269 1 14.3 14 3 decreased pre-pro B cell number 0.0278690671677942 0.110394345353221 1.0462030279269 1 14.3 14 3 midface hypoplasia 0.0278690671677942 0.110394345353221 1.0462030279269 1 14.3 14 3 absent nodal flow 0.0278690671677942 0.110394345353221 1.0462030279269 1 14.3 14 3 delayed optic fissure closure 0.0278690671677942 0.110394345353221 1.0462030279269 1 14.3 14 3 abnormal eyelid margin morphology 0.0278690671677942 0.110394345353221 1.0462030279269 1 14.3 14 3 abnormal mammary gland bud morphology 0.0278690671677942 0.110394345353221 1.0462030279269 1 14.3 14 3 decreased small intestinal villus height 0.0278690671677942 0.110394345353221 1.0462030279269 1 14.3 14 3 decreased platelet alpha-granule number 0.0278690671677942 0.110394345353221 1.0462030279269 1 14.3 14 3 rib bifurcation 5.89393660081607e-08 1.47348415020402e-06 1.00883863407236 0.964285714285714 14.3 14 3 abnormal brainstem morphology 5.89393660081607e-08 1.47348415020402e-06 1.00883863407236 0.964285714285714 14.3 14 3 abnormal erythrocyte osmotic lysis 2.30079517042899e-07 5.13293989815436e-06 1.00596444992971 0.961538461538462 14.3 14 3 increased thymocyte apoptosis 2.30079517042899e-07 5.13293989815436e-06 1.00596444992971 0.961538461538462 14.3 14 3 increased hemangiosarcoma incidence 8.93098591355062e-07 1.62753314724961e-05 1.00261123509661 0.958333333333333 14.3 14 3 abnormal cell death 5.71936116192029e-12 2.64291827339709e-10 1.00071593975616 0.956521739130435 14.3 14 3 abnormal pericardium morphology 1.3178791395992e-05 0.000184688696324113 0.993892876530551 0.95 14.3 14 3 abnormal sperm mitochondrial sheath morphology 1.3178791395992e-05 0.000184688696324113 0.993892876530551 0.95 14.3 14 3 increased skin tumor incidence 1.3178791395992e-05 0.000184688696324113 0.993892876530551 0.95 14.3 14 3 absent ductus venosus valve 1.3178791395992e-05 0.000184688696324113 0.993892876530551 0.95 14.3 14 3 abnormal response to novelty 2.56931781975658e-05 0.000335494912159815 0.991139710667585 0.947368421052632 14.3 14 3 abnormal female meiosis 1.7580234937768e-12 8.92466008320365e-11 0.985845160931113 0.942307692307692 14.3 14 3 abnormal interatrial septum morphology 9.68875449744488e-05 0.00106170822962089 0.984661673342961 0.941176470588235 14.3 14 3 abnormal embryonic-extraembryonic boundary morphology 9.68875449744488e-05 0.00106170822962089 0.984661673342961 0.941176470588235 14.3 14 3 increased B cell derived lymphoma incidence 6.56203682610145e-12 2.99505809264722e-10 0.983430846251282 0.94 14.3 14 3 increased fibroblast apoptosis 6.39696096720974e-08 1.56772811881125e-06 0.980815338681465 0.9375 14.3 14 3 disorganized yolk sac vascular plexus 0.000187291748561305 0.0018785815505897 0.980815338681465 0.9375 14.3 14 3 intraventricular hemorrhage 0.000187291748561305 0.0018785815505897 0.980815338681465 0.9375 14.3 14 3 abnormal meiosis 0.000187291748561305 0.0018785815505897 0.980815338681465 0.9375 14.3 14 3 increased cochlear outer hair cell number 0.000187291748561305 0.0018785815505897 0.980815338681465 0.9375 14.3 14 3 increased cellular sensitivity to gamma-irradiation 4.68814358821439e-11 1.88092857672311e-09 0.979424111250711 0.936170212765957 14.3 14 3 failure to gastrulate 9.00498381437623e-11 3.47285228500168e-09 0.977972395670794 0.934782608695652 14.3 14 3 abnormal male meiosis 6.89526520752351e-14 4.34227144397841e-12 0.977599550685788 0.934426229508197 14.3 14 3 macrocytosis 0.000360780225879246 0.00333621119655994 0.976456159398436 0.933333333333333 14.3 14 3 decreased hepatocyte number 0.000360780225879246 0.00333621119655994 0.976456159398436 0.933333333333333 14.3 14 3 abnormal cricoid cartilage morphology 0.000360780225879246 0.00333621119655994 0.976456159398436 0.933333333333333 14.3 14 3 immune system phenotype 0.000360780225879246 0.00333621119655994 0.976456159398436 0.933333333333333 14.3 14 3 increased mortality induced by gamma-irradiation 4.52657385838199e-07 9.13342843868804e-06 0.97405109496642 0.931034482758621 14.3 14 3 abnormal cell cycle 1.36638774749933e-24 2.39766368659064e-22 0.97342368685372 0.930434782608696 14.3 14 3 abnormal double-strand DNA break repair 6.32486247300416e-10 2.15521854816409e-08 0.973212119001763 0.930232558139535 14.3 14 3 incomplete embryo turning 9.25362663898743e-13 4.84597816094342e-11 0.972785271581148 0.929824561403509 14.3 14 3 midline facial cleft 0.000692220086168339 0.00567346775731052 0.971474240217832 0.928571428571429 14.3 14 3 absent visceral yolk sac blood islands 0.000692220086168339 0.00567346775731052 0.971474240217832 0.928571428571429 14.3 14 3 abnormal ventral body wall morphology 0.000692220086168339 0.00567346775731052 0.971474240217832 0.928571428571429 14.3 14 3 failure of zygotic cell division 0.000692220086168339 0.00567346775731052 0.971474240217832 0.928571428571429 14.3 14 3 abnormal pancreas development 0.000692220086168339 0.00567346775731052 0.971474240217832 0.928571428571429 14.3 14 3 lysosomal protein accumulation 0.000692220086168339 0.00567346775731052 0.971474240217832 0.928571428571429 14.3 14 3 multiple persisting craniopharyngeal ducts 0.000692220086168339 0.00567346775731052 0.971474240217832 0.928571428571429 14.3 14 3 embryonic lethality before implantation, complete penetrance 2.80737823493753e-26 6.07248118209313e-24 0.970876409916159 0.928 14.3 14 3 abnormal grip strength 0.00132216702720966 0.00981758352293739 0.965725871932519 0.923076923076923 14.3 14 3 dystrophic cardiac calcinosis 0.00132216702720966 0.00981758352293739 0.965725871932519 0.923076923076923 14.3 14 3 abnormal soleus morphology 0.00132216702720966 0.00981758352293739 0.965725871932519 0.923076923076923 14.3 14 3 absent hypoglossal nerve 0.00132216702720966 0.00981758352293739 0.965725871932519 0.923076923076923 14.3 14 3 abnormal primitive streak morphology 5.9467930616582e-06 9.15953420487602e-05 0.962506785692744 0.92 14.3 14 3 abnormal preimplantation embryo development 5.9467930616582e-06 9.15953420487602e-05 0.962506785692744 0.92 14.3 14 3 hemolytic anemia 1.12403983765382e-05 0.00016115556750224 0.959019442266321 0.916666666666667 14.3 14 3 abnormal thymus involution 0.002512346281991 0.0167097897766113 0.959019442266321 0.916666666666667 14.3 14 3 small intestinal inflammation 0.002512346281991 0.0167097897766113 0.959019442266321 0.916666666666667 14.3 14 3 delayed somite formation 0.002512346281991 0.0167097897766113 0.959019442266321 0.916666666666667 14.3 14 3 abnormal defecation 0.002512346281991 0.0167097897766113 0.959019442266321 0.916666666666667 14.3 14 3 abnormal rostral-caudal body axis extension 0.002512346281991 0.0167097897766113 0.959019442266321 0.916666666666667 14.3 14 3 abnormal colon goblet cell morphology 0.002512346281991 0.0167097897766113 0.959019442266321 0.916666666666667 14.3 14 3 abnormal liver development 1.05733744907344e-07 2.51686785126334e-06 0.956528482676019 0.914285714285714 14.3 14 3 abnormal nasal cavity morphology 2.11750997390151e-05 0.000281674120859894 0.955228851585426 0.91304347826087 14.3 14 3 abnormal hematopoietic stem cell physiology 2.11750997390151e-05 0.000281674120859894 0.955228851585426 0.91304347826087 14.3 14 3 azoospermia 2.41316216234676e-30 6.66971208759729e-28 0.954084522323269 0.911949685534591 14.3 14 3 enlarged liver sinusoidal spaces 1.98530187708245e-07 4.50998942396583e-06 0.953890996050993 0.911764705882353 14.3 14 3 decreased circulating total protein level 3.67820521089985e-11 1.51231991109312e-09 0.951093661751723 0.909090909090909 14.3 14 3 abnormal oogenesis 3.97456459773041e-05 0.000485370707628814 0.951093661751723 0.909090909090909 14.3 14 3 abnormal tracheal cartilage morphology 3.97456459773041e-05 0.000485370707628814 0.951093661751723 0.909090909090909 14.3 14 3 abnormal lysosome physiology 3.97456459773041e-05 0.000485370707628814 0.951093661751723 0.909090909090909 14.3 14 3 abnormal sperm midpiece morphology 3.97456459773041e-05 0.000485370707628814 0.951093661751723 0.909090909090909 14.3 14 3 abnormal ear position 0.00474530616575785 0.0280378838178685 0.951093661751723 0.909090909090909 14.3 14 3 abnormal eye distance/ position 0.00474530616575785 0.0280378838178685 0.951093661751723 0.909090909090909 14.3 14 3 social withdrawal 0.00474530616575785 0.0280378838178685 0.951093661751723 0.909090909090909 14.3 14 3 abnormal food preference 0.00474530616575785 0.0280378838178685 0.951093661751723 0.909090909090909 14.3 14 3 failure of somite differentiation 0.00474530616575785 0.0280378838178685 0.951093661751723 0.909090909090909 14.3 14 3 fatigue 0.00474530616575785 0.0280378838178685 0.951093661751723 0.909090909090909 14.3 14 3 abnormal pituitary gland development 0.00474530616575785 0.0280378838178685 0.951093661751723 0.909090909090909 14.3 14 3 aorta dilation 0.00474530616575785 0.0280378838178685 0.951093661751723 0.909090909090909 14.3 14 3 common atrioventricular valve 0.00474530616575785 0.0280378838178685 0.951093661751723 0.909090909090909 14.3 14 3 decreased embryonic cilium length 0.00474530616575785 0.0280378838178685 0.951093661751723 0.909090909090909 14.3 14 3 abnormal tooth development 3.71796414638957e-07 7.93857151428673e-06 0.951093661751723 0.909090909090909 14.3 14 3 arrest of spermatogenesis 4.90230821717751e-16 3.75215128930125e-14 0.94656464431481 0.904761904761905 14.3 14 3 spina bifida 1.26892357540924e-08 3.62810045267871e-07 0.94656464431481 0.904761904761905 14.3 14 3 abnormal scapula morphology 7.43074959207864e-05 0.000844017790424458 0.94656464431481 0.904761904761905 14.3 14 3 left pulmonary isomerism 7.43074959207864e-05 0.000844017790424458 0.94656464431481 0.904761904761905 14.3 14 3 preaxial polydactyly 1.29294308110502e-06 2.26492670017517e-05 0.944957573611389 0.903225806451613 14.3 14 3 decreased oocyte number 8.17587997702457e-10 2.6937088003773e-08 0.941582725134206 0.9 14.3 14 3 abnormal vascular regression 0.00013832265941173 0.00147990372166313 0.941582725134206 0.9 14.3 14 3 spleen atrophy 0.00013832265941173 0.00147990372166313 0.941582725134206 0.9 14.3 14 3 abnormal auchene hair morphology 0.00889993218968857 0.046509624625736 0.941582725134206 0.9 14.3 14 3 kidney hemorrhage 0.00889993218968857 0.046509624625736 0.941582725134206 0.9 14.3 14 3 abnormal epidermis suprabasal layer morphology 0.00889993218968857 0.046509624625736 0.941582725134206 0.9 14.3 14 3 absent trophoblast giant cells 0.00889993218968857 0.046509624625736 0.941582725134206 0.9 14.3 14 3 acrania 0.00889993218968857 0.046509624625736 0.941582725134206 0.9 14.3 14 3 bifid ureter 0.00889993218968857 0.046509624625736 0.941582725134206 0.9 14.3 14 3 abnormal reproductive system development 0.00889993218968857 0.046509624625736 0.941582725134206 0.9 14.3 14 3 abnormal embryonic erythrocyte morphology 0.00889993218968857 0.046509624625736 0.941582725134206 0.9 14.3 14 3 abnormal deltoid tuberosity morphology 0.00889993218968857 0.046509624625736 0.941582725134206 0.9 14.3 14 3 tachypnea 0.00889993218968857 0.046509624625736 0.941582725134206 0.9 14.3 14 3 increased platelet aggregation 0.00889993218968857 0.046509624625736 0.941582725134206 0.9 14.3 14 3 absent inguinal lymph nodes 0.00889993218968857 0.046509624625736 0.941582725134206 0.9 14.3 14 3 decreased transitional stage T2 B cell number 0.00889993218968857 0.046509624625736 0.941582725134206 0.9 14.3 14 3 aorta stenosis 0.00889993218968857 0.046509624625736 0.941582725134206 0.9 14.3 14 3 abnormal inferior vena cava valve morphology 0.00889993218968857 0.046509624625736 0.941582725134206 0.9 14.3 14 3 thin ventricle myocardium compact layer 0.00889993218968857 0.046509624625736 0.941582725134206 0.9 14.3 14 3 abnormal circadian temperature homeostasis 0.00889993218968857 0.046509624625736 0.941582725134206 0.9 14.3 14 3 abnormal somite development 1.07096670370481e-14 7.2000802039614e-13 0.940258417503919 0.89873417721519 14.3 14 3 aphagia 4.44023862830097e-06 7.08018819737094e-05 0.937975128486182 0.896551724137931 14.3 14 3 abnormal blastocyst morphology 0.000256263312273536 0.00251461534232908 0.936076393408275 0.894736842105263 14.3 14 3 abnormal cell nucleus morphology 5.12835813903426e-09 1.53696275552382e-07 0.934904833466587 0.893617021276596 14.3 14 3 shortened head 8.1854913260061e-06 0.000121924608822995 0.9341098463633 0.892857142857143 14.3 14 3 small superior cervical ganglion 8.1854913260061e-06 0.000121924608822995 0.9341098463633 0.892857142857143 14.3 14 3 premature aging 8.1854913260061e-06 0.000121924608822995 0.9341098463633 0.892857142857143 14.3 14 3 abnormal vocalization 2.73970239760468e-07 6.00441384497061e-06 0.933099997880745 0.891891891891892 14.3 14 3 embryonic lethality between implantation and placentation, complete penetrance 9.41421085783048e-09 2.75504111868863e-07 0.932485307500059 0.891304347826087 14.3 14 3 hydrops fetalis 7.56806598546866e-13 4.0485084169577e-11 0.929958247046129 0.888888888888889 14.3 14 3 abnormal lysosome morphology 5.02218177477095e-07 1.00747396489861e-05 0.929958247046129 0.888888888888889 14.3 14 3 lowered ear position 0.000472278155757115 0.00409335161130949 0.929958247046129 0.888888888888889 14.3 14 3 abnormal megakaryocyte differentiation 0.000472278155757115 0.00409335161130949 0.929958247046129 0.888888888888889 14.3 14 3 underdeveloped hair follicles 0.000472278155757115 0.00409335161130949 0.929958247046129 0.888888888888889 14.3 14 3 right pulmonary isomerism 0.000472278155757115 0.00409335161130949 0.929958247046129 0.888888888888889 14.3 14 3 abnormal radius morphology 0.000472278155757115 0.00409335161130949 0.929958247046129 0.888888888888889 14.3 14 3 absent spleen 0.000472278155757115 0.00409335161130949 0.929958247046129 0.888888888888889 14.3 14 3 abnormal bile duct morphology 0.000472278155757115 0.00409335161130949 0.929958247046129 0.888888888888889 14.3 14 3 small thoracic cage 0.000472278155757115 0.00409335161130949 0.929958247046129 0.888888888888889 14.3 14 3 increased gastrointestinal tumor incidence 0.000472278155757115 0.00409335161130949 0.929958247046129 0.888888888888889 14.3 14 3 increased effector memory CD4-positive, alpha-beta T cell number 0.000472278155757115 0.00409335161130949 0.929958247046129 0.888888888888889 14.3 14 3 increased effector memory CD8-positive, alpha-beta T cell number 0.000472278155757115 0.00409335161130949 0.929958247046129 0.888888888888889 14.3 14 3 abnormal hypoglossal nerve topology 0.000472278155757115 0.00409335161130949 0.929958247046129 0.888888888888889 14.3 14 3 crypts of Lieberkuhn abscesses 0.0165524569786589 0.0732637664313417 0.929958247046129 0.888888888888889 14.3 14 3 abnormal kindling response 0.0165524569786589 0.0732637664313417 0.929958247046129 0.888888888888889 14.3 14 3 increased pheochromocytoma incidence 0.0165524569786589 0.0732637664313417 0.929958247046129 0.888888888888889 14.3 14 3 abnormal vomeronasal organ morphology 0.0165524569786589 0.0732637664313417 0.929958247046129 0.888888888888889 14.3 14 3 genetic imprinting 0.0165524569786589 0.0732637664313417 0.929958247046129 0.888888888888889 14.3 14 3 abnormal abdominal wall morphology 0.0165524569786589 0.0732637664313417 0.929958247046129 0.888888888888889 14.3 14 3 pancreas cysts 0.0165524569786589 0.0732637664313417 0.929958247046129 0.888888888888889 14.3 14 3 abnormal artery development 0.0165524569786589 0.0732637664313417 0.929958247046129 0.888888888888889 14.3 14 3 abnormal thymus physiology 0.0165524569786589 0.0732637664313417 0.929958247046129 0.888888888888889 14.3 14 3 small scapula 0.0165524569786589 0.0732637664313417 0.929958247046129 0.888888888888889 14.3 14 3 short frontal bone 0.0165524569786589 0.0732637664313417 0.929958247046129 0.888888888888889 14.3 14 3 absent adrenal gland 0.0165524569786589 0.0732637664313417 0.929958247046129 0.888888888888889 14.3 14 3 abnormal leukopoiesis 0.0165524569786589 0.0732637664313417 0.929958247046129 0.888888888888889 14.3 14 3 abnormal liver vasculature morphology 0.0165524569786589 0.0732637664313417 0.929958247046129 0.888888888888889 14.3 14 3 multiflagellated sperm 0.0165524569786589 0.0732637664313417 0.929958247046129 0.888888888888889 14.3 14 3 decreased transitional stage T1 B cell number 0.0165524569786589 0.0732637664313417 0.929958247046129 0.888888888888889 14.3 14 3 axonal spheroids 0.0165524569786589 0.0732637664313417 0.929958247046129 0.888888888888889 14.3 14 3 shortened ST segment 0.0165524569786589 0.0732637664313417 0.929958247046129 0.888888888888889 14.3 14 3 abnormal oxidative phosphorylation 0.0165524569786589 0.0732637664313417 0.929958247046129 0.888888888888889 14.3 14 3 reduced AMPA-mediated synaptic currents 0.0165524569786589 0.0732637664313417 0.929958247046129 0.888888888888889 14.3 14 3 increased core body temperature 0.0165524569786589 0.0732637664313417 0.929958247046129 0.888888888888889 14.3 14 3 trigeminal neuroma 0.0165524569786589 0.0732637664313417 0.929958247046129 0.888888888888889 14.3 14 3 abnormal ductus venosus valve topology 0.0165524569786589 0.0732637664313417 0.929958247046129 0.888888888888889 14.3 14 3 abnormal infrahyoid muscle connection 0.0165524569786589 0.0732637664313417 0.929958247046129 0.888888888888889 14.3 14 3 symmetric azygos veins 0.0165524569786589 0.0732637664313417 0.929958247046129 0.888888888888889 14.3 14 3 increased endoplasmic reticulum stress 0.0165524569786589 0.0732637664313417 0.929958247046129 0.888888888888889 14.3 14 3 decreased platelet dense granule number 0.0165524569786589 0.0732637664313417 0.929958247046129 0.888888888888889 14.3 14 3 abnormal apoptosis 6.01885015076095e-10 2.06508824138177e-08 0.929958247046129 0.888888888888889 14.3 14 3 abnormal atrioventricular cushion morphology 1.50322081919408e-05 0.000207736765985848 0.929958247046129 0.888888888888889 14.3 14 3 omphalocele 3.14856864939934e-08 8.33198352700091e-07 0.92731632020793 0.886363636363636 14.3 14 3 abnormal erythropoiesis 7.72126363702379e-18 7.83944624371292e-16 0.926636967592393 0.885714285714286 14.3 14 3 embryonic lethality between somite formation and embryo turning, complete penetrance 2.51797706437668e-12 1.2526935895274e-10 0.926636967592393 0.885714285714286 14.3 14 3 abnormal hippocampus pyramidal cell morphology 9.17702619415216e-07 1.66626661736887e-05 0.926636967592393 0.885714285714286 14.3 14 3 increased embryonic tissue cell apoptosis 1.64148155982439e-13 9.72186995253137e-12 0.925487293935331 0.884615384615385 14.3 14 3 liver hypoplasia 2.00216515766594e-09 6.26463626376608e-08 0.925487293935331 0.884615384615385 14.3 14 3 abnormal direction of heart looping 1.67129311661931e-06 2.89710217950561e-05 0.923120318759026 0.882352941176471 14.3 14 3 abnormal bone marrow cavity morphology 0.00086532327546273 0.00681168242947323 0.923120318759026 0.882352941176471 14.3 14 3 abnormal glutamate-mediated receptor currents 0.00086532327546273 0.00681168242947323 0.923120318759026 0.882352941176471 14.3 14 3 absence seizures 0.00086532327546273 0.00681168242947323 0.923120318759026 0.882352941176471 14.3 14 3 abnormal duodenum morphology 0.00086532327546273 0.00681168242947323 0.923120318759026 0.882352941176471 14.3 14 3 abnormal testis development 0.00086532327546273 0.00681168242947323 0.923120318759026 0.882352941176471 14.3 14 3 increased regulatory T cell number 0.00086532327546273 0.00681168242947323 0.923120318759026 0.882352941176471 14.3 14 3 increased brain size 0.00086532327546273 0.00681168242947323 0.923120318759026 0.882352941176471 14.3 14 3 increased trabecular bone mass 0.00086532327546273 0.00681168242947323 0.923120318759026 0.882352941176471 14.3 14 3 abnormal ductus venosus valve morphology 0.00086532327546273 0.00681168242947323 0.923120318759026 0.882352941176471 14.3 14 3 abnormal nest building behavior 5.00601706856578e-05 0.000594389854799875 0.920658664575668 0.88 14.3 14 3 abnormal embryonic neuroepithelium morphology 4.22496703433055e-10 1.4907241840989e-08 0.919937145246063 0.879310344827586 14.3 14 3 embryonic lethality, complete penetrance 3.33388358175996e-49 1.84289675769509e-46 0.918297328587871 0.877742946708464 14.3 14 3 vertebral transformation 2.1517714321608e-08 5.88190267857141e-07 0.915427649436033 0.875 14.3 14 3 curly tail 2.1517714321608e-08 5.88190267857141e-07 0.915427649436033 0.875 14.3 14 3 scoliosis 5.48306478188732e-06 8.49789635199046e-05 0.915427649436033 0.875 14.3 14 3 ocular hypertelorism 9.07180092763545e-05 0.00100293799144414 0.915427649436033 0.875 14.3 14 3 abnormal nursing 9.07180092763545e-05 0.00100293799144414 0.915427649436033 0.875 14.3 14 3 abnormal impulse conducting system conduction 9.07180092763545e-05 0.00100293799144414 0.915427649436033 0.875 14.3 14 3 abnormal truncus arteriosus septation 9.07180092763545e-05 0.00100293799144414 0.915427649436033 0.875 14.3 14 3 abnormal bone marrow cell number 0.00157519956710484 0.0113218362104329 0.915427649436033 0.875 14.3 14 3 increased intestinal adenocarcinoma incidence 0.00157519956710484 0.0113218362104329 0.915427649436033 0.875 14.3 14 3 decreased aggression towards mice 0.00157519956710484 0.0113218362104329 0.915427649436033 0.875 14.3 14 3 small pancreas 0.00157519956710484 0.0113218362104329 0.915427649436033 0.875 14.3 14 3 dystonia 0.00157519956710484 0.0113218362104329 0.915427649436033 0.875 14.3 14 3 impaired somite development 0.00157519956710484 0.0113218362104329 0.915427649436033 0.875 14.3 14 3 decreased liver cholesterol level 0.00157519956710484 0.0113218362104329 0.915427649436033 0.875 14.3 14 3 abnormal ear pigmentation 0.0304734148577014 0.116529776262156 0.915427649436033 0.875 14.3 14 3 schistocytosis 0.0304734148577014 0.116529776262156 0.915427649436033 0.875 14.3 14 3 abnormal cecum morphology 0.0304734148577014 0.116529776262156 0.915427649436033 0.875 14.3 14 3 absent mammary gland 0.0304734148577014 0.116529776262156 0.915427649436033 0.875 14.3 14 3 increased sensitivity to skin irradiation 0.0304734148577014 0.116529776262156 0.915427649436033 0.875 14.3 14 3 dermal cysts 0.0304734148577014 0.116529776262156 0.915427649436033 0.875 14.3 14 3 abnormal muscle precursor cell migration 0.0304734148577014 0.116529776262156 0.915427649436033 0.875 14.3 14 3 decreased susceptibility to age related obesity 0.0304734148577014 0.116529776262156 0.915427649436033 0.875 14.3 14 3 loss of GABAergic neurons 0.0304734148577014 0.116529776262156 0.915427649436033 0.875 14.3 14 3 abnormal ovary development 0.0304734148577014 0.116529776262156 0.915427649436033 0.875 14.3 14 3 abnormal eyelid aperture 0.0304734148577014 0.116529776262156 0.915427649436033 0.875 14.3 14 3 binucleate 0.0304734148577014 0.116529776262156 0.915427649436033 0.875 14.3 14 3 abnormal extraembryonic tissue physiology 0.0304734148577014 0.116529776262156 0.915427649436033 0.875 14.3 14 3 abnormal lateral ganglionic eminence morphology 0.0304734148577014 0.116529776262156 0.915427649436033 0.875 14.3 14 3 abnormal NK cell morphology 0.0304734148577014 0.116529776262156 0.915427649436033 0.875 14.3 14 3 abnormal somite size 0.0304734148577014 0.116529776262156 0.915427649436033 0.875 14.3 14 3 abnormal vertebral body development 0.0304734148577014 0.116529776262156 0.915427649436033 0.875 14.3 14 3 skin fibrosis 0.0304734148577014 0.116529776262156 0.915427649436033 0.875 14.3 14 3 abnormal olfactory bulb glomerular layer morphology 0.0304734148577014 0.116529776262156 0.915427649436033 0.875 14.3 14 3 abnormal olfactory bulb mitral cell layer morphology 0.0304734148577014 0.116529776262156 0.915427649436033 0.875 14.3 14 3 increased caudal vertebrae number 0.0304734148577014 0.116529776262156 0.915427649436033 0.875 14.3 14 3 pulmonary artery hypoplasia 0.0304734148577014 0.116529776262156 0.915427649436033 0.875 14.3 14 3 myocardial trabeculae hypoplasia 0.0304734148577014 0.116529776262156 0.915427649436033 0.875 14.3 14 3 delayed suture closure 0.0304734148577014 0.116529776262156 0.915427649436033 0.875 14.3 14 3 abnormal visual evoked potential 0.0304734148577014 0.116529776262156 0.915427649436033 0.875 14.3 14 3 abnormal stomach position or orientation 0.0304734148577014 0.116529776262156 0.915427649436033 0.875 14.3 14 3 decreased alveolar lamellar body number 0.0304734148577014 0.116529776262156 0.915427649436033 0.875 14.3 14 3 abnormal maxillary prominence morphology 0.0304734148577014 0.116529776262156 0.915427649436033 0.875 14.3 14 3 absent ureteric bud 0.0304734148577014 0.116529776262156 0.915427649436033 0.875 14.3 14 3 decreased surfactant secretion 0.0304734148577014 0.116529776262156 0.915427649436033 0.875 14.3 14 3 increased aorta wall thickness 0.0304734148577014 0.116529776262156 0.915427649436033 0.875 14.3 14 3 decreased cranium length 0.0304734148577014 0.116529776262156 0.915427649436033 0.875 14.3 14 3 increased cornea thickness 0.0304734148577014 0.116529776262156 0.915427649436033 0.875 14.3 14 3 increased testis apoptosis 0.0304734148577014 0.116529776262156 0.915427649436033 0.875 14.3 14 3 absent hypoglossal canal 0.0304734148577014 0.116529776262156 0.915427649436033 0.875 14.3 14 3 retropleural edema 0.0304734148577014 0.116529776262156 0.915427649436033 0.875 14.3 14 3 abnormal umbilical vein topology 0.0304734148577014 0.116529776262156 0.915427649436033 0.875 14.3 14 3 embryo cyst 0.0304734148577014 0.116529776262156 0.915427649436033 0.875 14.3 14 3 abnormal heart looping 6.12739460365935e-07 1.20489281237966e-05 0.912074434602935 0.871794871794872 14.3 14 3 abnormal mitochondrial ATP synthesis coupled electron transport 9.87292101758481e-06 0.000143200530794415 0.911209088839554 0.870967741935484 14.3 14 3 abnormal vitelline vasculature morphology 8.54040324134239e-18 8.49770122513568e-16 0.909741763414692 0.869565217391304 14.3 14 3 abnormal cell morphology 1.52604232565357e-17 1.43246425851443e-15 0.90854473477862 0.868421052631579 14.3 14 3 decreased total retina thickness 1.09872480133092e-06 1.97334147531456e-05 0.90854473477862 0.868421052631579 14.3 14 3 pericardial edema 5.93815725559398e-11 2.32616790130551e-09 0.907734980113042 0.867647058823529 14.3 14 3 abnormal myocardial trabeculae morphology 1.24089249314988e-07 2.91200007236824e-06 0.906709290869976 0.866666666666667 14.3 14 3 abnormal incisor morphology 9.14203552539119e-10 2.97265534240661e-08 0.906709290869976 0.866666666666667 14.3 14 3 abnormal prostate gland morphology 0.00284657917804744 0.0183204804796714 0.906709290869976 0.866666666666667 14.3 14 3 abnormal ear development 0.00284657917804744 0.0183204804796714 0.906709290869976 0.866666666666667 14.3 14 3 abnormal placenta size 0.00284657917804744 0.0183204804796714 0.906709290869976 0.866666666666667 14.3 14 3 abnormal olfactory nerve morphology 0.00284657917804744 0.0183204804796714 0.906709290869976 0.866666666666667 14.3 14 3 absent chorion 0.00284657917804744 0.0183204804796714 0.906709290869976 0.866666666666667 14.3 14 3 decreased embryo size 2.03323073883228e-68 2.02306458513812e-65 0.906125635066391 0.866108786610879 14.3 14 3 rib fusion 1.05872160098151e-10 4.02071753044504e-09 0.905668292832238 0.865671641791045 14.3 14 3 embryonic growth arrest 3.94469675911196e-33 1.22655414853638e-30 0.904577290521945 0.864628820960699 14.3 14 3 lethality, incomplete penetrance 2.21160356004622e-07 4.97860982408595e-06 0.903538978664137 0.863636363636364 14.3 14 3 abnormal enterocyte morphology 0.000293199212229507 0.0027784115825558 0.903538978664137 0.863636363636364 14.3 14 3 increased body size 0.000293199212229507 0.0027784115825558 0.903538978664137 0.863636363636364 14.3 14 3 testis hypoplasia 0.000293199212229507 0.0027784115825558 0.903538978664137 0.863636363636364 14.3 14 3 aphakia 0.000293199212229507 0.0027784115825558 0.903538978664137 0.863636363636364 14.3 14 3 abnormal vascular branching morphogenesis 0.000293199212229507 0.0027784115825558 0.903538978664137 0.863636363636364 14.3 14 3 cleft upper lip 0.000293199212229507 0.0027784115825558 0.903538978664137 0.863636363636364 14.3 14 3 abnormal occipital bone morphology 0.000293199212229507 0.0027784115825558 0.903538978664137 0.863636363636364 14.3 14 3 increased mammary gland tumor incidence 0.000293199212229507 0.0027784115825558 0.903538978664137 0.863636363636364 14.3 14 3 increased adenoma incidence 0.000293199212229507 0.0027784115825558 0.903538978664137 0.863636363636364 14.3 14 3 lethality throughout fetal growth and development, complete penetrance 1.71287443557779e-27 4.26077515849974e-25 0.903038403052689 0.863157894736842 14.3 14 3 abnormal fertility/fecundity 2.1882522448882e-11 9.30474779343488e-10 0.902887544649239 0.863013698630137 14.3 14 3 astrocytosis 2.1882522448882e-11 9.30474779343488e-10 0.902887544649239 0.863013698630137 14.3 14 3 distended abdomen 2.51937202478174e-08 6.81188903439628e-07 0.902606533897714 0.862745098039216 14.3 14 3 failure of chorioallantoic fusion 2.51937202478174e-08 6.81188903439628e-07 0.902606533897714 0.862745098039216 14.3 14 3 embryonic lethality between implantation and somite formation, complete penetrance 1.14941279115851e-34 3.81221909067572e-32 0.901015668949285 0.861224489795918 14.3 14 3 abnormal pharyngeal arch morphology 3.49370615943158e-06 5.68012684417389e-05 0.900897051825938 0.861111111111111 14.3 14 3 abnormal trophoblast giant cell morphology 3.49370615943158e-06 5.68012684417389e-05 0.900897051825938 0.861111111111111 14.3 14 3 abnormal left-right axis patterning 3.92862724626235e-07 8.21215149166184e-06 0.900221210076631 0.86046511627907 14.3 14 3 abnormal spermatogenesis 5.29970666122453e-26 1.05464162558368e-23 0.898369991372008 0.858695652173913 14.3 14 3 abnormal embryo size 1.77656164837956e-16 1.44891708208005e-14 0.898068085919547 0.858407079646018 14.3 14 3 pallor 1.39763310374127e-24 2.39766368659064e-22 0.896745452508768 0.857142857142857 14.3 14 3 subcutaneous edema 5.61125093875484e-05 0.00066151595782714 0.896745452508768 0.857142857142857 14.3 14 3 abnormal kidney blood vessel morphology 0.00510184867345755 0.0297907243549898 0.896745452508768 0.857142857142857 14.3 14 3 increased lactate dehydrogenase level 0.00510184867345755 0.0297907243549898 0.896745452508768 0.857142857142857 14.3 14 3 testis degeneration 0.00510184867345755 0.0297907243549898 0.896745452508768 0.857142857142857 14.3 14 3 abnormal vitelline vein topology 0.00510184867345755 0.0297907243549898 0.896745452508768 0.857142857142857 14.3 14 3 growth retardation of molars 0.0554010264245514 0.180724974212933 0.896745452508768 0.857142857142857 14.3 14 3 asymmetric rib joints 0.0554010264245514 0.180724974212933 0.896745452508768 0.857142857142857 14.3 14 3 polyphalangy 0.0554010264245514 0.180724974212933 0.896745452508768 0.857142857142857 14.3 14 3 mammary gland hyperplasia 0.0554010264245514 0.180724974212933 0.896745452508768 0.857142857142857 14.3 14 3 prostate gland epithelial hyperplasia 0.0554010264245514 0.180724974212933 0.896745452508768 0.857142857142857 14.3 14 3 retina hyperplasia 0.0554010264245514 0.180724974212933 0.896745452508768 0.857142857142857 14.3 14 3 limp posture 0.0554010264245514 0.180724974212933 0.896745452508768 0.857142857142857 14.3 14 3 abnormal circulating alanine transaminase level 0.0554010264245514 0.180724974212933 0.896745452508768 0.857142857142857 14.3 14 3 abnormal axial mesoderm 0.0554010264245514 0.180724974212933 0.896745452508768 0.857142857142857 14.3 14 3 absent amniotic folds 0.0554010264245514 0.180724974212933 0.896745452508768 0.857142857142857 14.3 14 3 abnormal gastrulation movements 0.0554010264245514 0.180724974212933 0.896745452508768 0.857142857142857 14.3 14 3 abnormal brain ventricular system morphology 0.0554010264245514 0.180724974212933 0.896745452508768 0.857142857142857 14.3 14 3 decreased mortality induced by ionizing radiation 0.0554010264245514 0.180724974212933 0.896745452508768 0.857142857142857 14.3 14 3 abnormal response to novel odor 0.0554010264245514 0.180724974212933 0.896745452508768 0.857142857142857 14.3 14 3 anuria 0.0554010264245514 0.180724974212933 0.896745452508768 0.857142857142857 14.3 14 3 abnormal optic tract morphology 0.0554010264245514 0.180724974212933 0.896745452508768 0.857142857142857 14.3 14 3 absent deltoid tuberosity 0.0554010264245514 0.180724974212933 0.896745452508768 0.857142857142857 14.3 14 3 decreased tidal volume 0.0554010264245514 0.180724974212933 0.896745452508768 0.857142857142857 14.3 14 3 absent popliteal lymph nodes 0.0554010264245514 0.180724974212933 0.896745452508768 0.857142857142857 14.3 14 3 abnormal sperm annulus morphology 0.0554010264245514 0.180724974212933 0.896745452508768 0.857142857142857 14.3 14 3 abnormal cerebellum white matter morphology 0.0554010264245514 0.180724974212933 0.896745452508768 0.857142857142857 14.3 14 3 increased DN3 thymocyte number 0.0554010264245514 0.180724974212933 0.896745452508768 0.857142857142857 14.3 14 3 arteritis 0.0554010264245514 0.180724974212933 0.896745452508768 0.857142857142857 14.3 14 3 focal dorsal hair loss 0.0554010264245514 0.180724974212933 0.896745452508768 0.857142857142857 14.3 14 3 abnormal T wave 0.0554010264245514 0.180724974212933 0.896745452508768 0.857142857142857 14.3 14 3 heart block 0.0554010264245514 0.180724974212933 0.896745452508768 0.857142857142857 14.3 14 3 abnormal conotruncal ridge morphology 0.0554010264245514 0.180724974212933 0.896745452508768 0.857142857142857 14.3 14 3 abnormal aortic valve cusp morphology 0.0554010264245514 0.180724974212933 0.896745452508768 0.857142857142857 14.3 14 3 abnormal brain ependyma motile cilium physiology 0.0554010264245514 0.180724974212933 0.896745452508768 0.857142857142857 14.3 14 3 embryonic lethality at implantation, incomplete penetrance 0.0554010264245514 0.180724974212933 0.896745452508768 0.857142857142857 14.3 14 3 increased circulating lactate dehydrogenase level 0.0554010264245514 0.180724974212933 0.896745452508768 0.857142857142857 14.3 14 3 absent heart tube 0.0554010264245514 0.180724974212933 0.896745452508768 0.857142857142857 14.3 14 3 decreased CD8-positive, naive alpha-beta T cell number 0.0554010264245514 0.180724974212933 0.896745452508768 0.857142857142857 14.3 14 3 abnormal Mullerian duct topology 0.0554010264245514 0.180724974212933 0.896745452508768 0.857142857142857 14.3 14 3 absent connection between subcutaneous lymph vessels and lymph sac 0.0554010264245514 0.180724974212933 0.896745452508768 0.857142857142857 14.3 14 3 increased grip strength 1.93114070435518e-13 1.13028529460788e-11 0.896745452508767 0.857142857142857 14.3 14 3 abnormal reproductive system morphology 6.95450588244438e-07 1.34625162510353e-05 0.896745452508767 0.857142857142857 14.3 14 3 abnormal salivary gland morphology 0.000522413640357387 0.00443516699791468 0.896745452508767 0.857142857142857 14.3 14 3 increased muscle cell glucose uptake 0.000522413640357387 0.00443516699791468 0.896745452508767 0.857142857142857 14.3 14 3 pale yolk sac 2.90507266732031e-12 1.40317830290471e-10 0.894944758829031 0.855421686746988 14.3 14 3 abnormal neural tube closure 2.90507266732031e-12 1.40317830290471e-10 0.894944758829031 0.855421686746988 14.3 14 3 preweaning lethality, complete penetrance 3.67424703234395e-99 1.82793789859112e-95 0.894927725240169 0.855405405405405 14.3 14 3 small testis 1.62075538870961e-37 6.71938171569193e-35 0.894579400691114 0.855072463768116 14.3 14 3 microcephaly 2.13649140435702e-10 7.87336647161199e-09 0.894579400691114 0.855072463768116 14.3 14 3 increased tumor incidence 1.3496032011467e-17 1.31652469131467e-15 0.894334846453636 0.854838709677419 14.3 14 3 abnormal head morphology 1.59700973701086e-08 4.43861644783744e-07 0.89402804204662 0.854545454545454 14.3 14 3 small heart 1.39345075107874e-07 3.23944742365268e-06 0.89363175302089 0.854166666666667 14.3 14 3 abnormal developmental patterning 5.10721124005356e-12 2.41984532564442e-10 0.893100145791252 0.853658536585366 14.3 14 3 decreased erythrocyte cell number 9.59295850588444e-22 1.35110781827397e-19 0.892937616192382 0.853503184713376 14.3 14 3 abnormal brown adipose tissue morphology 1.09302110442012e-05 0.000157616811434496 0.892349641467058 0.852941176470588 14.3 14 3 abnormal neural tube morphology 3.49256649534275e-22 5.11044656303829e-20 0.891209986752541 0.851851851851852 14.3 14 3 abnormal neuronal precursor proliferation 2.80642169133702e-08 7.50642360989336e-07 0.891209986752541 0.851851851851852 14.3 14 3 abnormal trigeminal nerve morphology 9.9140626265601e-05 0.00108163292910387 0.891209986752541 0.851851851851852 14.3 14 3 embryonic lethality during organogenesis, complete penetrance 1.67653573809492e-73 2.08519132425556e-70 0.891140793430588 0.851785714285714 14.3 14 3 abnormal cell proliferation 0.000924593678490441 0.00711863119745182 0.889272573737861 0.85 14.3 14 3 small gonad 0.000924593678490441 0.00711863119745182 0.889272573737861 0.85 14.3 14 3 increased mammary adenocarcinoma incidence 0.000924593678490441 0.00711863119745182 0.889272573737861 0.85 14.3 14 3 abnormal hyoid bone morphology 0.000924593678490441 0.00711863119745182 0.889272573737861 0.85 14.3 14 3 abnormal male reproductive system physiology 0.000924593678490441 0.00711863119745182 0.889272573737861 0.85 14.3 14 3 abnormal incus morphology 0.000924593678490441 0.00711863119745182 0.889272573737861 0.85 14.3 14 3 abnormal seminiferous tubule morphology 7.63194960782009e-20 9.26071934119633e-18 0.888555996321473 0.849315068493151 14.3 14 3 atrioventricular septal defect 4.9168742415022e-08 1.25443330007556e-06 0.888285589749251 0.849056603773585 14.3 14 3 abnormal ovarian folliculogenesis 1.92039948729087e-05 0.000261950083778681 0.887687417634942 0.848484848484849 14.3 14 3 abnormal forebrain development 2.34320786446431e-10 8.57166112184553e-09 0.886366454215842 0.847222222222222 14.3 14 3 small liver 4.77864301694386e-11 1.90189992074366e-09 0.885248715938142 0.846153846153846 14.3 14 3 abnormal placenta vasculature 8.58746575373059e-08 2.08403132316145e-06 0.885248715938142 0.846153846153846 14.3 14 3 ventricular hypoplasia 0.000174181179304045 0.00178302750419264 0.885248715938142 0.846153846153846 14.3 14 3 increased leukemia incidence 0.000174181179304045 0.00178302750419264 0.885248715938142 0.846153846153846 14.3 14 3 abnormal tail bud morphology 0.0090583321832884 0.0468453249603532 0.885248715938142 0.846153846153846 14.3 14 3 abnormal telomere length 0.0090583321832884 0.0468453249603532 0.885248715938142 0.846153846153846 14.3 14 3 tracheoesophageal fistula 0.0090583321832884 0.0468453249603532 0.885248715938142 0.846153846153846 14.3 14 3 increased cochlear inner hair cell number 0.0090583321832884 0.0468453249603532 0.885248715938142 0.846153846153846 14.3 14 3 abnormal vertebral arch development 0.0090583321832884 0.0468453249603532 0.885248715938142 0.846153846153846 14.3 14 3 hyperalgesia 0.0090583321832884 0.0468453249603532 0.885248715938142 0.846153846153846 14.3 14 3 empty decidua capsularis 0.0090583321832884 0.0468453249603532 0.885248715938142 0.846153846153846 14.3 14 3 abnormal aorta tunica media morphology 0.0090583321832884 0.0468453249603532 0.885248715938142 0.846153846153846 14.3 14 3 decreased cardiac stroke volume 0.0090583321832884 0.0468453249603532 0.885248715938142 0.846153846153846 14.3 14 3 abnormal embryo development 3.41254207980309e-18 3.61221209511072e-16 0.884656972144066 0.845588235294118 14.3 14 3 decreased cell proliferation 6.48436948296127e-24 1.00811681805414e-21 0.882203634359977 0.843243243243243 14.3 14 3 abnormal extraembryonic tissue morphology 8.40175261462841e-14 5.22483990722204e-12 0.882092749036402 0.843137254901961 14.3 14 3 abnormal axial skeleton morphology 1.4425660131184e-10 5.35579545915228e-09 0.881013076148965 0.842105263157895 14.3 14 3 decreased hair follicle number 6.57249925903732e-06 9.99944459134883e-05 0.881013076148965 0.842105263157895 14.3 14 3 incomplete somite formation 6.57249925903732e-06 9.99944459134883e-05 0.881013076148965 0.842105263157895 14.3 14 3 kyphoscoliosis 0.00162435732100288 0.011478945556803 0.881013076148965 0.842105263157895 14.3 14 3 abnormal stationary movement 0.00162435732100288 0.011478945556803 0.881013076148965 0.842105263157895 14.3 14 3 increased malignant tumor incidence 0.00162435732100288 0.011478945556803 0.881013076148965 0.842105263157895 14.3 14 3 abnormal digestive system development 0.00162435732100288 0.011478945556803 0.881013076148965 0.842105263157895 14.3 14 3 abnormal optic vesicle formation 0.00162435732100288 0.011478945556803 0.881013076148965 0.842105263157895 14.3 14 3 increased liver cholesterol level 0.00162435732100288 0.011478945556803 0.881013076148965 0.842105263157895 14.3 14 3 abnormal neurocranium morphology 2.49762724801078e-10 9.00412721656061e-09 0.878810543458592 0.84 14.3 14 3 testicular atrophy 2.59367964925499e-07 5.73491389113047e-06 0.878810543458592 0.84 14.3 14 3 abnormal egg cylinder morphology 0.000304171661877511 0.00285519626007664 0.878810543458592 0.84 14.3 14 3 increased cellular sensitivity to ionizing radiation 0.000304171661877511 0.00285519626007664 0.878810543458592 0.84 14.3 14 3 increased neuron apoptosis 5.08822657268593e-11 2.0090418411994e-09 0.878293899988011 0.839506172839506 14.3 14 3 prenatal lethality 1.04951064206335e-08 3.03564851410766e-07 0.877460604067719 0.838709677419355 14.3 14 3 abnormal nose morphology 5.84104154863266e-05 0.000681182803511735 0.877460604067719 0.838709677419355 14.3 14 3 inner cell mass degeneration 5.84104154863266e-05 0.000681182803511735 0.877460604067719 0.838709677419355 14.3 14 3 abnormal podocyte morphology 5.84104154863266e-05 0.000681182803511735 0.877460604067719 0.838709677419355 14.3 14 3 decreased circulating serum albumin level 4.34967165239425e-13 2.43141758097319e-11 0.877119710282145 0.838383838383838 14.3 14 3 pale liver 4.31386051685466e-10 1.51137014586985e-08 0.876548482857669 0.837837837837838 14.3 14 3 malocclusion 1.14023289256999e-05 0.000162075961158163 0.876548482857669 0.837837837837838 14.3 14 3 abnormal chromosome morphology 1.14023289256999e-05 0.000162075961158163 0.876548482857669 0.837837837837838 14.3 14 3 abnormal calcium ion homeostasis 1.14023289256999e-05 0.000162075961158163 0.876548482857669 0.837837837837838 14.3 14 3 abnormal vasculogenesis 2.25161674399521e-06 3.81987427002855e-05 0.875890907101587 0.837209302325581 14.3 14 3 abnormal rib morphology 3.27250747256547e-17 2.96013175927513e-15 0.875710682635105 0.837037037037037 14.3 14 3 increased T cell derived lymphoma incidence 4.48407988504541e-07 9.13342843868804e-06 0.875394370306178 0.836734693877551 14.3 14 3 abnormal craniofacial morphology 2.64239509692918e-13 1.52859483804915e-11 0.873528741764204 0.83495145631068 14.3 14 3 abnormal testis morphology 1.11303721589613e-14 7.38314686544434e-13 0.873352092878104 0.834782608695652 14.3 14 3 oxidative stress 1.08202037089501e-11 4.76376225239175e-10 0.871835856605746 0.833333333333333 14.3 14 3 kinked tail 4.53574209031836e-13 2.50725743325932e-11 0.871835856605746 0.833333333333333 14.3 14 3 cortical renal glomerulopathies 0.0028305488739908 0.0183204804796714 0.871835856605746 0.833333333333333 14.3 14 3 delayed kidney development 0.0028305488739908 0.0183204804796714 0.871835856605746 0.833333333333333 14.3 14 3 abnormal thymus medulla morphology 0.0028305488739908 0.0183204804796714 0.871835856605746 0.833333333333333 14.3 14 3 abnormal body wall morphology 0.0028305488739908 0.0183204804796714 0.871835856605746 0.833333333333333 14.3 14 3 long tibia 0.0028305488739908 0.0183204804796714 0.871835856605746 0.833333333333333 14.3 14 3 absent inner cell mass 0.0028305488739908 0.0183204804796714 0.871835856605746 0.833333333333333 14.3 14 3 atrioventricular block 0.0028305488739908 0.0183204804796714 0.871835856605746 0.833333333333333 14.3 14 3 increased adipocyte glucose uptake 0.0028305488739908 0.0183204804796714 0.871835856605746 0.833333333333333 14.3 14 3 thymus atrophy 7.72383061335914e-07 1.42847796659709e-05 0.871835856605746 0.833333333333333 14.3 14 3 decreased body height 0.000527705679013611 0.00446485672294679 0.871835856605746 0.833333333333333 14.3 14 3 abnormal lung saccule morphology 0.000527705679013611 0.00446485672294679 0.871835856605746 0.833333333333333 14.3 14 3 abnormal adipose tissue distribution 0.0159101055845921 0.0730191653905403 0.871835856605746 0.833333333333333 14.3 14 3 abnormal supraoccipital bone morphology 0.0159101055845921 0.0730191653905403 0.871835856605746 0.833333333333333 14.3 14 3 mesocardia 0.0159101055845921 0.0730191653905403 0.871835856605746 0.833333333333333 14.3 14 3 abnormal superior cervical ganglion morphology 0.0159101055845921 0.0730191653905403 0.871835856605746 0.833333333333333 14.3 14 3 absent optic nerve 0.0159101055845921 0.0730191653905403 0.871835856605746 0.833333333333333 14.3 14 3 increased papilloma incidence 0.0159101055845921 0.0730191653905403 0.871835856605746 0.833333333333333 14.3 14 3 altered tumor susceptibility 0.0159101055845921 0.0730191653905403 0.871835856605746 0.833333333333333 14.3 14 3 increased growth rate 0.0159101055845921 0.0730191653905403 0.871835856605746 0.833333333333333 14.3 14 3 abnormal AMPA-mediated synaptic currents 0.0159101055845921 0.0730191653905403 0.871835856605746 0.833333333333333 14.3 14 3 decreased synaptic depression 0.0159101055845921 0.0730191653905403 0.871835856605746 0.833333333333333 14.3 14 3 loss of dopaminergic neurons 0.0159101055845921 0.0730191653905403 0.871835856605746 0.833333333333333 14.3 14 3 decreased circulating ketone body level 0.0159101055845921 0.0730191653905403 0.871835856605746 0.833333333333333 14.3 14 3 abnormal vascular endothelial cell development 0.0159101055845921 0.0730191653905403 0.871835856605746 0.833333333333333 14.3 14 3 decreased cochlear nerve compound action potential 0.0159101055845921 0.0730191653905403 0.871835856605746 0.833333333333333 14.3 14 3 hemoperitoneum 0.0159101055845921 0.0730191653905403 0.871835856605746 0.833333333333333 14.3 14 3 increased fibrosarcoma incidence 0.0159101055845921 0.0730191653905403 0.871835856605746 0.833333333333333 14.3 14 3 persistent right dorsal aorta 0.0159101055845921 0.0730191653905403 0.871835856605746 0.833333333333333 14.3 14 3 abnormal pulmonary valve cusp morphology 0.0159101055845921 0.0730191653905403 0.871835856605746 0.833333333333333 14.3 14 3 abnormal respiratory motile cilium morphology 0.0159101055845921 0.0730191653905403 0.871835856605746 0.833333333333333 14.3 14 3 large anterior fontanelle 0.0991254382320048 0.27610057028438 0.871835856605746 0.833333333333333 14.3 14 3 poor arterial differentiation 0.0991254382320048 0.27610057028438 0.871835856605746 0.833333333333333 14.3 14 3 absent organized vascular network 0.0991254382320048 0.27610057028438 0.871835856605746 0.833333333333333 14.3 14 3 hemoglobinuria 0.0991254382320048 0.27610057028438 0.871835856605746 0.833333333333333 14.3 14 3 abnormal urethra morphology 0.0991254382320048 0.27610057028438 0.871835856605746 0.833333333333333 14.3 14 3 absent radius 0.0991254382320048 0.27610057028438 0.871835856605746 0.833333333333333 14.3 14 3 absent superior cervical ganglion 0.0991254382320048 0.27610057028438 0.871835856605746 0.833333333333333 14.3 14 3 epidermal necrosis 0.0991254382320048 0.27610057028438 0.871835856605746 0.833333333333333 14.3 14 3 jumpy 0.0991254382320048 0.27610057028438 0.871835856605746 0.833333333333333 14.3 14 3 non-obstructive hydrocephaly 0.0991254382320048 0.27610057028438 0.871835856605746 0.833333333333333 14.3 14 3 abnormal internal nares morphology 0.0991254382320048 0.27610057028438 0.871835856605746 0.833333333333333 14.3 14 3 abnormal blood gas level 0.0991254382320048 0.27610057028438 0.871835856605746 0.833333333333333 14.3 14 3 abnormal pulmonary ventilation 0.0991254382320048 0.27610057028438 0.871835856605746 0.833333333333333 14.3 14 3 abnormal lymph node cortex morphology 0.0991254382320048 0.27610057028438 0.871835856605746 0.833333333333333 14.3 14 3 chromatolysis 0.0991254382320048 0.27610057028438 0.871835856605746 0.833333333333333 14.3 14 3 ectopic thymus 0.0991254382320048 0.27610057028438 0.871835856605746 0.833333333333333 14.3 14 3 calcified joint 0.0991254382320048 0.27610057028438 0.871835856605746 0.833333333333333 14.3 14 3 abnormal glutaminergic neuron morphology 0.0991254382320048 0.27610057028438 0.871835856605746 0.833333333333333 14.3 14 3 enlarged pancreas 0.0991254382320048 0.27610057028438 0.871835856605746 0.833333333333333 14.3 14 3 abnormal periodontal ligament morphology 0.0991254382320048 0.27610057028438 0.871835856605746 0.833333333333333 14.3 14 3 abnormal milk ejection 0.0991254382320048 0.27610057028438 0.871835856605746 0.833333333333333 14.3 14 3 abnormal metopic suture morphology 0.0991254382320048 0.27610057028438 0.871835856605746 0.833333333333333 14.3 14 3 shortened QT interval 0.0991254382320048 0.27610057028438 0.871835856605746 0.833333333333333 14.3 14 3 absent molars 0.0991254382320048 0.27610057028438 0.871835856605746 0.833333333333333 14.3 14 3 abnormal cholesterol level 0.0991254382320048 0.27610057028438 0.871835856605746 0.833333333333333 14.3 14 3 abnormal extensor digitorum longus morphology 0.0991254382320048 0.27610057028438 0.871835856605746 0.833333333333333 14.3 14 3 vestibular saccular degeneration 0.0991254382320048 0.27610057028438 0.871835856605746 0.833333333333333 14.3 14 3 bowed humerus 0.0991254382320048 0.27610057028438 0.871835856605746 0.833333333333333 14.3 14 3 enlarged interparietal bone 0.0991254382320048 0.27610057028438 0.871835856605746 0.833333333333333 14.3 14 3 abnormal immature B cell morphology 0.0991254382320048 0.27610057028438 0.871835856605746 0.833333333333333 14.3 14 3 abnormal anus morphology 0.0991254382320048 0.27610057028438 0.871835856605746 0.833333333333333 14.3 14 3 osteomyelitis 0.0991254382320048 0.27610057028438 0.871835856605746 0.833333333333333 14.3 14 3 abnormal pancreatic delta cell morphology 0.0991254382320048 0.27610057028438 0.871835856605746 0.833333333333333 14.3 14 3 decreased susceptibility to fungal infection 0.0991254382320048 0.27610057028438 0.871835856605746 0.833333333333333 14.3 14 3 abnormal heart size 0.0991254382320048 0.27610057028438 0.871835856605746 0.833333333333333 14.3 14 3 abnormal ligament morphology 0.0991254382320048 0.27610057028438 0.871835856605746 0.833333333333333 14.3 14 3 abnormal dermis papillary layer morphology 0.0991254382320048 0.27610057028438 0.871835856605746 0.833333333333333 14.3 14 3 abnormal right lung morphology 0.0991254382320048 0.27610057028438 0.871835856605746 0.833333333333333 14.3 14 3 absent brachial lymph nodes 0.0991254382320048 0.27610057028438 0.871835856605746 0.833333333333333 14.3 14 3 abnormal eyelid development 0.0991254382320048 0.27610057028438 0.871835856605746 0.833333333333333 14.3 14 3 abnormal thromboxane level 0.0991254382320048 0.27610057028438 0.871835856605746 0.833333333333333 14.3 14 3 abnormal neural crest cell morphology 0.0991254382320048 0.27610057028438 0.871835856605746 0.833333333333333 14.3 14 3 absent tongue 0.0991254382320048 0.27610057028438 0.871835856605746 0.833333333333333 14.3 14 3 increased transitional stage T1 B cell number 0.0991254382320048 0.27610057028438 0.871835856605746 0.833333333333333 14.3 14 3 abnormal olfactory bulb layer morphology 0.0991254382320048 0.27610057028438 0.871835856605746 0.833333333333333 14.3 14 3 increased erythrocyte clearance 0.0991254382320048 0.27610057028438 0.871835856605746 0.833333333333333 14.3 14 3 enlarged lymphatic vessel 0.0991254382320048 0.27610057028438 0.871835856605746 0.833333333333333 14.3 14 3 abnormal epiglottis morphology 0.0991254382320048 0.27610057028438 0.871835856605746 0.833333333333333 14.3 14 3 cerebral arteriovenous malformation 0.0991254382320048 0.27610057028438 0.871835856605746 0.833333333333333 14.3 14 3 common truncal valve 0.0991254382320048 0.27610057028438 0.871835856605746 0.833333333333333 14.3 14 3 thick pulmonary valve cusps 0.0991254382320048 0.27610057028438 0.871835856605746 0.833333333333333 14.3 14 3 absent third pharyngeal arch 0.0991254382320048 0.27610057028438 0.871835856605746 0.833333333333333 14.3 14 3 abnormal respiratory epithelium morphology 0.0991254382320048 0.27610057028438 0.871835856605746 0.833333333333333 14.3 14 3 abnormal ureteric bud tip morphology 0.0991254382320048 0.27610057028438 0.871835856605746 0.833333333333333 14.3 14 3 absent midbrain 0.0991254382320048 0.27610057028438 0.871835856605746 0.833333333333333 14.3 14 3 delayed limb development 0.0991254382320048 0.27610057028438 0.871835856605746 0.833333333333333 14.3 14 3 abnormal Rathke's pouch development 0.0991254382320048 0.27610057028438 0.871835856605746 0.833333333333333 14.3 14 3 thymus cortex atrophy 0.0991254382320048 0.27610057028438 0.871835856605746 0.833333333333333 14.3 14 3 increased bone trabecular spacing 0.0991254382320048 0.27610057028438 0.871835856605746 0.833333333333333 14.3 14 3 increased CD11b-high dendritic cell number 0.0991254382320048 0.27610057028438 0.871835856605746 0.833333333333333 14.3 14 3 absent thymus corticomedullary boundary 0.0991254382320048 0.27610057028438 0.871835856605746 0.833333333333333 14.3 14 3 additional anastomosis between intracranial vertebral arteries 0.0991254382320048 0.27610057028438 0.871835856605746 0.833333333333333 14.3 14 3 abnormal Wolffian duct connection 0.0991254382320048 0.27610057028438 0.871835856605746 0.833333333333333 14.3 14 3 decreased tear production 0.0991254382320048 0.27610057028438 0.871835856605746 0.833333333333333 14.3 14 3 abnormal excitatory synapse morphology 0.0991254382320048 0.27610057028438 0.871835856605746 0.833333333333333 14.3 14 3 double outlet right ventricle 1.59391894031742e-13 9.5539117205773e-12 0.870206256873773 0.831775700934579 14.3 14 3 decreased rib number 1.85393015673795e-11 8.02026306936636e-10 0.869876674905509 0.831460674157303 14.3 14 3 edema 7.67957300660302e-21 9.79637838662821e-19 0.869808331357826 0.831395348837209 14.3 14 3 abnormal ovary morphology 2.1890539480689e-09 6.76431266561663e-08 0.869379980953336 0.830985915492958 14.3 14 3 perinatal lethality, complete penetrance 2.08306506200983e-25 3.9858648782688e-23 0.869379980953336 0.830985915492958 14.3 14 3 prenatal lethality, complete penetrance 1.00854911389351e-32 2.95148931860012e-30 0.869326976442852 0.830935251798561 14.3 14 3 ventricular septal defect 1.00211584985333e-16 8.59573509141434e-15 0.869271633498082 0.830882352941177 14.3 14 3 abnormal mesoderm development 2.65325798135142e-07 5.84068958284217e-06 0.868545909977045 0.830188679245283 14.3 14 3 abnormal embryonic tissue morphology 7.26741036767258e-18 7.53236803732731e-16 0.868277342905315 0.829931972789116 14.3 14 3 abnormal artery morphology 3.38275232752618e-05 0.000424979616905119 0.866853937425142 0.828571428571429 14.3 14 3 abnormal midbrain development 3.38275232752618e-05 0.000424979616905119 0.866853937425142 0.828571428571429 14.3 14 3 holoprosencephaly 3.38275232752618e-05 0.000424979616905119 0.866853937425142 0.828571428571429 14.3 14 3 abnormal definitive hematopoiesis 1.10649441544761e-11 4.82878045337883e-10 0.866211109143774 0.827956989247312 14.3 14 3 abnormal parietal bone morphology 0.000173804615151798 0.00178302750419264 0.865823195525707 0.827586206896552 14.3 14 3 lordosis 0.000173804615151798 0.00178302750419264 0.865823195525707 0.827586206896552 14.3 14 3 distended pericardium 4.53458658161999e-07 9.13342843868804e-06 0.865129426939548 0.826923076923077 14.3 14 3 kinked neural tube 4.53458658161999e-07 9.13342843868804e-06 0.865129426939548 0.826923076923077 14.3 14 3 lethality throughout fetal growth and development, incomplete penetrance 4.72840124457965e-21 6.19047268204836e-19 0.865017028676986 0.826815642458101 14.3 14 3 embryonic lethality during organogenesis, incomplete penetrance 1.5853098680996e-26 3.58496208808886e-24 0.864254675243957 0.826086956521739 14.3 14 3 abnormal forelimb morphology 2.26505107469029e-06 3.81987427002855e-05 0.864254675243957 0.826086956521739 14.3 14 3 abnormal allantois morphology 2.26505107469029e-06 3.81987427002855e-05 0.864254675243957 0.826086956521739 14.3 14 3 bidirectional circling 0.000909036354381651 0.00708848881355598 0.864254675243957 0.826086956521739 14.3 14 3 abnormal cardiovascular development 0.000909036354381651 0.00708848881355598 0.864254675243957 0.826086956521739 14.3 14 3 abnormal sacral vertebrae morphology 0.000909036354381651 0.00708848881355598 0.864254675243957 0.826086956521739 14.3 14 3 dilated heart 0.000909036354381651 0.00708848881355598 0.864254675243957 0.826086956521739 14.3 14 3 abnormal B cell morphology 0.000909036354381651 0.00708848881355598 0.864254675243957 0.826086956521739 14.3 14 3 abnormal ulna morphology 0.000909036354381651 0.00708848881355598 0.864254675243957 0.826086956521739 14.3 14 3 abnormal vertebrae morphology 2.76964873367307e-13 1.56579573295722e-11 0.863837362508446 0.825688073394495 14.3 14 3 male infertility 4.24424129186506e-56 3.01644291814695e-53 0.863169496202111 0.825049701789264 14.3 14 3 increased hepatocellular carcinoma incidence 1.55465005063448e-07 3.56423225894311e-06 0.862658637062528 0.824561403508772 14.3 14 3 cleft palate 1.43633748037872e-15 1.05084984777708e-13 0.862518526840494 0.824427480916031 14.3 14 3 abnormal axon morphology 4.70218920672106e-13 2.57070234103706e-11 0.862148791532349 0.824074074074074 14.3 14 3 hyperlipidemia 0.00488795559476797 0.0287102468523857 0.861578964175091 0.823529411764706 14.3 14 3 abnormal dorsal-ventral axis patterning 0.00488795559476797 0.0287102468523857 0.861578964175091 0.823529411764706 14.3 14 3 abnormal cranial suture morphology 0.00488795559476797 0.0287102468523857 0.861578964175091 0.823529411764706 14.3 14 3 enhanced behavioral response to cocaine 0.00488795559476797 0.0287102468523857 0.861578964175091 0.823529411764706 14.3 14 3 abnormal gastrulation 7.72108629668398e-07 1.42847796659709e-05 0.86157896417509 0.823529411764706 14.3 14 3 increased lung adenocarcinoma incidence 7.72108629668398e-07 1.42847796659709e-05 0.86157896417509 0.823529411764706 14.3 14 3 abnormal visceral yolk sac morphology 7.63880095372487e-10 2.53353564965208e-08 0.860799959686686 0.822784810126582 14.3 14 3 pericardial effusion 5.33956802976262e-08 1.35532402796271e-06 0.860586361681801 0.82258064516129 14.3 14 3 abnormal ectoderm development 3.85488738931112e-06 6.2064934504281e-05 0.86021137851767 0.822222222222222 14.3 14 3 small placenta 3.85488738931112e-06 6.2064934504281e-05 0.86021137851767 0.822222222222222 14.3 14 3 failure of blastocyst to hatch from the zona pellucida 0.000297069963904643 0.0027990967242909 0.859381058654236 0.821428571428571 14.3 14 3 abnormal mitotic spindle morphology 0.000297069963904643 0.0027990967242909 0.859381058654236 0.821428571428571 14.3 14 3 prolonged QRS complex duration 0.000297069963904643 0.0027990967242909 0.859381058654236 0.821428571428571 14.3 14 3 increased hepatocyte apoptosis 1.93764082071467e-05 0.000261950083778681 0.85842299727335 0.82051282051282 14.3 14 3 failure of heart looping 1.93764082071467e-05 0.000261950083778681 0.85842299727335 0.82051282051282 14.3 14 3 decreased trabecular bone volume 1.93764082071467e-05 0.000261950083778681 0.85842299727335 0.82051282051282 14.3 14 3 anophthalmia 9.17210234675845e-11 3.51009301347102e-09 0.858121584704083 0.820224719101124 14.3 14 3 abnormal interventricular septum morphology 1.30959031814241e-06 2.28603923956437e-05 0.857886482900054 0.82 14.3 14 3 abnormal brain morphology 2.62296206448431e-18 2.89983028240209e-16 0.857756519790995 0.819875776397516 14.3 14 3 embryonic lethality, incomplete penetrance 6.53194634894152e-06 9.9989024879951e-05 0.855984295576551 0.818181818181818 14.3 14 3 increased skin papilloma incidence 0.00155387856693285 0.0113218362104329 0.855984295576551 0.818181818181818 14.3 14 3 prolonged PR interval 0.00155387856693285 0.0113218362104329 0.855984295576551 0.818181818181818 14.3 14 3 embryonic lethality before implantation, incomplete penetrance 0.00155387856693285 0.0113218362104329 0.855984295576551 0.818181818181818 14.3 14 3 premature suture closure 0.0275957492973767 0.110394345353221 0.855984295576551 0.818181818181818 14.3 14 3 abnormal thrombopoiesis 0.0275957492973767 0.110394345353221 0.855984295576551 0.818181818181818 14.3 14 3 decreased atrioventricular cushion size 0.0275957492973767 0.110394345353221 0.855984295576551 0.818181818181818 14.3 14 3 abnormal awl hair morphology 0.0275957492973767 0.110394345353221 0.855984295576551 0.818181818181818 14.3 14 3 impaired myelopoiesis 0.0275957492973767 0.110394345353221 0.855984295576551 0.818181818181818 14.3 14 3 abnormal fear/anxiety-related behavior 0.0275957492973767 0.110394345353221 0.855984295576551 0.818181818181818 14.3 14 3 abnormal vestibular ganglion morphology 0.0275957492973767 0.110394345353221 0.855984295576551 0.818181818181818 14.3 14 3 loss of cortex neurons 0.0275957492973767 0.110394345353221 0.855984295576551 0.818181818181818 14.3 14 3 abnormal radial glial cell morphology 0.0275957492973767 0.110394345353221 0.855984295576551 0.818181818181818 14.3 14 3 abnormal coronal suture morphology 0.0275957492973767 0.110394345353221 0.855984295576551 0.818181818181818 14.3 14 3 pharyngeal arch hypoplasia 0.0275957492973767 0.110394345353221 0.855984295576551 0.818181818181818 14.3 14 3 palatal shelf hypoplasia 0.0275957492973767 0.110394345353221 0.855984295576551 0.818181818181818 14.3 14 3 aberrant origin of the right subclavian artery 0.0275957492973767 0.110394345353221 0.855984295576551 0.818181818181818 14.3 14 3 abnormal brain ependyma motile cilium morphology 0.0275957492973767 0.110394345353221 0.855984295576551 0.818181818181818 14.3 14 3 hypolactation 0.0275957492973767 0.110394345353221 0.855984295576551 0.818181818181818 14.3 14 3 abnormal joint morphology 4.46348808972852e-07 9.13342843868804e-06 0.855984295576551 0.818181818181818 14.3 14 3 belly spot 9.82618188688439e-05 0.00107440120631318 0.855984295576551 0.818181818181818 14.3 14 3 hydroencephaly 2.7488075603596e-13 1.56579573295722e-11 0.85515725760981 0.817391304347826 14.3 14 3 absent mesoderm 1.52545714640908e-07 3.51349504786351e-06 0.854399139473631 0.816666666666667 14.3 14 3 increased grooming behavior 3.27915745923488e-05 0.000415109627473118 0.853481417519309 0.815789473684211 14.3 14 3 neurodegeneration 7.52117282267335e-07 1.417342227e-05 0.852461726458952 0.814814814814815 14.3 14 3 axon degeneration 7.52117282267335e-07 1.417342227e-05 0.852461726458952 0.814814814814815 14.3 14 3 abnormal trigeminal ganglion morphology 0.000504359612673197 0.00433365988436815 0.852461726458952 0.814814814814815 14.3 14 3 abnormal eye muscle morphology 0.000504359612673197 0.00433365988436815 0.852461726458952 0.814814814814815 14.3 14 3 decreased circulating fructosamine level 0.000504359612673197 0.00433365988436815 0.852461726458952 0.814814814814815 14.3 14 3 kidney cortex cysts 0.000166016922268884 0.00172428849329374 0.850039960190603 0.8125 14.3 14 3 abnormal heart atrium morphology 0.000166016922268884 0.00172428849329374 0.850039960190603 0.8125 14.3 14 3 abnormal spongiotrophoblast layer morphology 0.000166016922268884 0.00172428849329374 0.850039960190603 0.8125 14.3 14 3 bradykinesia 0.000166016922268884 0.00172428849329374 0.850039960190603 0.8125 14.3 14 3 pancreatic islet hyperplasia 0.000166016922268884 0.00172428849329374 0.850039960190603 0.8125 14.3 14 3 absent mandible 0.00835589082546545 0.0450873718619204 0.850039960190603 0.8125 14.3 14 3 disorganized retinal layers 0.00835589082546545 0.0450873718619204 0.850039960190603 0.8125 14.3 14 3 white spotting 0.00835589082546545 0.0450873718619204 0.850039960190603 0.8125 14.3 14 3 abnormal amnion morphology 0.00835589082546545 0.0450873718619204 0.850039960190603 0.8125 14.3 14 3 blepharitis 0.00835589082546545 0.0450873718619204 0.850039960190603 0.8125 14.3 14 3 impaired behavioral response to addictive substance 0.00835589082546545 0.0450873718619204 0.850039960190603 0.8125 14.3 14 3 abnormal thoracic cage shape 0.00835589082546545 0.0450873718619204 0.850039960190603 0.8125 14.3 14 3 enlarged kidney 1.26242995627748e-06 2.22715923137605e-05 0.84880623020484 0.811320754716981 14.3 14 3 small seminiferous tubules 1.03214676781467e-08 3.00288314027952e-07 0.848272725346132 0.810810810810811 14.3 14 3 increased circulating phosphate level 5.52005866999296e-05 0.000652310971097743 0.848272725346132 0.810810810810811 14.3 14 3 decreased double-positive T cell number 3.01854406386358e-11 1.25143805981011e-09 0.847424452620785 0.81 14.3 14 3 abnormal hematopoietic system physiology 0.00263385884055591 0.0172868703585299 0.846926260702725 0.80952380952381 14.3 14 3 increased incidence of induced tumors 0.00263385884055591 0.0172868703585299 0.846926260702725 0.80952380952381 14.3 14 3 abnormal erythrocyte physiology 0.00263385884055591 0.0172868703585299 0.846926260702725 0.80952380952381 14.3 14 3 abnormal clavicle morphology 0.00263385884055591 0.0172868703585299 0.846926260702725 0.80952380952381 14.3 14 3 complete atrioventricular septal defect 0.00263385884055591 0.0172868703585299 0.846926260702725 0.80952380952381 14.3 14 3 embryonic lethality at implantation, complete penetrance 0.00263385884055591 0.0172868703585299 0.846926260702725 0.80952380952381 14.3 14 3 absent segment of posterior cerebral artery 0.00263385884055591 0.0172868703585299 0.846926260702725 0.80952380952381 14.3 14 3 pulmonary hypoplasia 6.23274340388807e-06 9.57033902294542e-05 0.845866277898341 0.808510638297872 14.3 14 3 abnormal nasal bone morphology 0.000850131688686069 0.00678877231334381 0.845010137940954 0.807692307692308 14.3 14 3 short tail 2.03654950524533e-09 6.33239611787221e-08 0.84452533579641 0.807228915662651 14.3 14 3 decreased birth body size 2.08466716568664e-12 1.04759789386778e-10 0.844304197976091 0.807017543859649 14.3 14 3 absent vitelline blood vessels 7.17347437375923e-07 1.37261673113278e-05 0.844304197976091 0.807017543859649 14.3 14 3 abnormal craniofacial bone morphology 7.17347437375923e-07 1.37261673113278e-05 0.844304197976091 0.807017543859649 14.3 14 3 abnormal facial morphology 7.17347437375923e-07 1.37261673113278e-05 0.844304197976091 0.807017543859649 14.3 14 3 teratozoospermia 7.01762818971024e-10 2.3431342445509e-08 0.844095624804654 0.806818181818182 14.3 14 3 abnormal object recognition memory 0.000278726190186171 0.00269254911878874 0.843712119295883 0.806451612903226 14.3 14 3 increased lung adenoma incidence 0.000278726190186171 0.00269254911878874 0.843712119295883 0.806451612903226 14.3 14 3 abnormal behavior 5.60035875438096e-28 1.46640972647607e-25 0.842983734732462 0.805755395683453 14.3 14 3 renal hypoplasia 9.24035356648805e-05 0.00101930729475118 0.842774661385555 0.805555555555556 14.3 14 3 thick ventricular wall 3.08877911001095e-05 0.000398100416380945 0.842065851746038 0.804878048780488 14.3 14 3 thymus hypoplasia 1.7335934797873e-14 1.12008150155088e-12 0.84151113115859 0.804347826086957 14.3 14 3 abnormal trophoblast layer morphology 3.51326524088579e-06 5.6933207079501e-05 0.841065179313779 0.803921568627451 14.3 14 3 abnormal heart development 2.52058182065957e-16 2.02256363835183e-14 0.840935345232378 0.80379746835443 14.3 14 3 atelectasis 4.75222157023352e-08 1.22498975709387e-06 0.839909473124409 0.802816901408451 14.3 14 3 increased circulating alkaline phosphatase level 1.4478164923664e-16 1.20048117492047e-14 0.839545639694422 0.802469135802469 14.3 14 3 extramedullary hematopoiesis 2.73893810037149e-11 1.14506025624775e-09 0.838936390318737 0.80188679245283 14.3 14 3 increased monocyte cell number 1.30730547575316e-10 4.92715510747877e-09 0.836962422341516 0.8 14.3 14 3 spleen hyperplasia 2.69407720652615e-08 7.24488329863113e-07 0.836962422341516 0.8 14.3 14 3 trabecula carnea hypoplasia 1.72401821874631e-05 0.000236280733836444 0.836962422341516 0.8 14.3 14 3 abnormal response to new environment 0.000464814362433161 0.00409335161130949 0.836962422341516 0.8 14.3 14 3 liver hemorrhage 0.000464814362433161 0.00409335161130949 0.836962422341516 0.8 14.3 14 3 abnormal brain vasculature morphology 0.000464814362433161 0.00409335161130949 0.836962422341516 0.8 14.3 14 3 diaphragmatic hernia 0.001421841747558 0.0104639980681969 0.836962422341516 0.8 14.3 14 3 decreased placenta weight 0.001421841747558 0.0104639980681969 0.836962422341516 0.8 14.3 14 3 abnormal dopamine level 0.00442341189105263 0.0267393367654761 0.836962422341516 0.8 14.3 14 3 abnormal trachea morphology 0.00442341189105263 0.0267393367654761 0.836962422341516 0.8 14.3 14 3 abnormal Peyer's patch T cell area morphology 0.00442341189105263 0.0267393367654761 0.836962422341516 0.8 14.3 14 3 absent placental labyrinth 0.00442341189105263 0.0267393367654761 0.836962422341516 0.8 14.3 14 3 abnormal optic stalk morphology 0.00442341189105263 0.0267393367654761 0.836962422341516 0.8 14.3 14 3 decreased muscle cell glucose uptake 0.00442341189105263 0.0267393367654761 0.836962422341516 0.8 14.3 14 3 abnormal fontanelle morphology 0.014122926655098 0.0663470822560083 0.836962422341516 0.8 14.3 14 3 absent incisors 0.014122926655098 0.0663470822560083 0.836962422341516 0.8 14.3 14 3 interdigital webbing 0.014122926655098 0.0663470822560083 0.836962422341516 0.8 14.3 14 3 abnormal epidermis stratum spinosum morphology 0.014122926655098 0.0663470822560083 0.836962422341516 0.8 14.3 14 3 abnormal pup retrieval 0.014122926655098 0.0663470822560083 0.836962422341516 0.8 14.3 14 3 abnormal seizure response to electrical stimulation 0.014122926655098 0.0663470822560083 0.836962422341516 0.8 14.3 14 3 increased airway responsiveness 0.014122926655098 0.0663470822560083 0.836962422341516 0.8 14.3 14 3 abnormal lymph node B cell domain morphology 0.014122926655098 0.0663470822560083 0.836962422341516 0.8 14.3 14 3 abnormal neurotransmitter secretion 0.014122926655098 0.0663470822560083 0.836962422341516 0.8 14.3 14 3 abnormal dendritic cell morphology 0.014122926655098 0.0663470822560083 0.836962422341516 0.8 14.3 14 3 abnormal cerebral aqueduct morphology 0.014122926655098 0.0663470822560083 0.836962422341516 0.8 14.3 14 3 abnormal aorta wall morphology 0.014122926655098 0.0663470822560083 0.836962422341516 0.8 14.3 14 3 retarded hair growth 0.0471625561345403 0.166053585824018 0.836962422341516 0.8 14.3 14 3 enlarged testis 0.0471625561345403 0.166053585824018 0.836962422341516 0.8 14.3 14 3 abnormal prostate gland epithelium morphology 0.0471625561345403 0.166053585824018 0.836962422341516 0.8 14.3 14 3 fused cornea and lens 0.0471625561345403 0.166053585824018 0.836962422341516 0.8 14.3 14 3 abnormal mammary gland physiology 0.0471625561345403 0.166053585824018 0.836962422341516 0.8 14.3 14 3 ketoaciduria 0.0471625561345403 0.166053585824018 0.836962422341516 0.8 14.3 14 3 primary sex reversal 0.0471625561345403 0.166053585824018 0.836962422341516 0.8 14.3 14 3 impaired basement membrane formation 0.0471625561345403 0.166053585824018 0.836962422341516 0.8 14.3 14 3 abnormal tibialis anterior morphology 0.0471625561345403 0.166053585824018 0.836962422341516 0.8 14.3 14 3 aneurysm 0.0471625561345403 0.166053585824018 0.836962422341516 0.8 14.3 14 3 cochlear ganglion hypoplasia 0.0471625561345403 0.166053585824018 0.836962422341516 0.8 14.3 14 3 absent CD4-positive, alpha beta T cells 0.0471625561345403 0.166053585824018 0.836962422341516 0.8 14.3 14 3 absent pharyngeal arches 0.0471625561345403 0.166053585824018 0.836962422341516 0.8 14.3 14 3 ascites 0.0471625561345403 0.166053585824018 0.836962422341516 0.8 14.3 14 3 osteosclerosis 0.0471625561345403 0.166053585824018 0.836962422341516 0.8 14.3 14 3 absent axillary lymph nodes 0.0471625561345403 0.166053585824018 0.836962422341516 0.8 14.3 14 3 abnormal sperm principal piece morphology 0.0471625561345403 0.166053585824018 0.836962422341516 0.8 14.3 14 3 increased serotonin level 0.0471625561345403 0.166053585824018 0.836962422341516 0.8 14.3 14 3 increased circulating fructosamine level 0.0471625561345403 0.166053585824018 0.836962422341516 0.8 14.3 14 3 abnormal heart and great artery attachment 0.0471625561345403 0.166053585824018 0.836962422341516 0.8 14.3 14 3 thick aortic valve cusps 0.0471625561345403 0.166053585824018 0.836962422341516 0.8 14.3 14 3 thick aortic valve 0.0471625561345403 0.166053585824018 0.836962422341516 0.8 14.3 14 3 sinus bradycardia 0.0471625561345403 0.166053585824018 0.836962422341516 0.8 14.3 14 3 decreased trabecular bone connectivity density 0.0471625561345403 0.166053585824018 0.836962422341516 0.8 14.3 14 3 increased compact bone area 0.0471625561345403 0.166053585824018 0.836962422341516 0.8 14.3 14 3 lethality during fetal growth through weaning, complete penetrance 0.0471625561345403 0.166053585824018 0.836962422341516 0.8 14.3 14 3 decreased circulating lactate level 0.0471625561345403 0.166053585824018 0.836962422341516 0.8 14.3 14 3 increased fatty acid oxidation 0.0471625561345403 0.166053585824018 0.836962422341516 0.8 14.3 14 3 hemorrhage 5.14410751984663e-23 7.75513179128393e-21 0.836962422341516 0.8 14.3 14 3 thrombocytopenia 9.40570292275252e-15 6.49907945009636e-13 0.836962422341516 0.8 14.3 14 3 abnormal embryo turning 1.97519117544528e-06 3.41200558952787e-05 0.836962422341516 0.8 14.3 14 3 increased carcinoma incidence 0.00015376483726667 0.00162072047754594 0.836962422341516 0.8 14.3 14 3 abnormal embryonic epiblast morphology 0.00015376483726667 0.00162072047754594 0.836962422341516 0.8 14.3 14 3 increased red blood cell distribution width 0.00015376483726667 0.00162072047754594 0.836962422341516 0.8 14.3 14 3 decreased bone volume 0.00015376483726667 0.00162072047754594 0.836962422341516 0.8 14.3 14 3 abnormal cranium morphology 1.28515634188886e-13 7.79713756206962e-12 0.835400925284909 0.798507462686567 14.3 14 3 abnormal placenta labyrinth morphology 1.5243004072015e-08 4.26033400327386e-07 0.834313807080942 0.79746835443038 14.3 14 3 abnormal nervous system morphology 1.5243004072015e-08 4.26033400327386e-07 0.834313807080942 0.79746835443038 14.3 14 3 abnormal sternum morphology 1.2941965575861e-07 3.02282998778912e-06 0.833929949796801 0.797101449275362 14.3 14 3 preweaning lethality, incomplete penetrance 2.82408576281315e-38 1.27725696999959e-35 0.8338928780053 0.797066014669927 14.3 14 3 decreased circulating LDL cholesterol level 3.7826044376047e-07 8.00785407535462e-06 0.833693037879245 0.796875 14.3 14 3 decreased caudal vertebrae number 3.7826044376047e-07 8.00785407535462e-06 0.833693037879245 0.796875 14.3 14 3 abnormal small intestine morphology 3.25728859104434e-06 5.34818836318337e-05 0.833087596312157 0.796296296296296 14.3 14 3 abnormal cell adhesion 3.25728859104434e-06 5.34818836318337e-05 0.833087596312157 0.796296296296296 14.3 14 3 increased sarcoma incidence 9.60727862264006e-06 0.000140577091610689 0.832692205900998 0.795918367346939 14.3 14 3 abnormal craniofacial development 9.60727862264006e-06 0.000140577091610689 0.832692205900998 0.795918367346939 14.3 14 3 hypoglycemia 1.02327699744262e-09 3.30571627420587e-08 0.832462624371938 0.795698924731183 14.3 14 3 abnormal oocyte morphology 0.000254271031079288 0.00249999679766691 0.830808286883123 0.794117647058823 14.3 14 3 gliosis 6.21039642489072e-07 1.21640638637131e-05 0.830319863434044 0.793650793650794 14.3 14 3 kyphosis 1.34682481412836e-14 8.81638611880077e-13 0.82998773548867 0.793333333333333 14.3 14 3 abnormal spinal nerve morphology 0.00076958713412388 0.00624761850146006 0.829747229045469 0.793103448275862 14.3 14 3 blood in lymph vessels 0.00076958713412388 0.00624761850146006 0.829747229045469 0.793103448275862 14.3 14 3 abnormal hepatocyte morphology 3.91753293001807e-11 1.59751855138032e-09 0.82942222033844 0.792792792792793 14.3 14 3 abnormal digestive system morphology 0.00235809292078021 0.0159817382129798 0.828244063775459 0.791666666666667 14.3 14 3 abnormal startle reflex 0.00235809292078021 0.0159817382129798 0.828244063775459 0.791666666666667 14.3 14 3 blindness 0.00235809292078021 0.0159817382129798 0.828244063775459 0.791666666666667 14.3 14 3 abnormal cardiac muscle contractility 0.00235809292078021 0.0159817382129798 0.828244063775459 0.791666666666667 14.3 14 3 increased body temperature 0.00235809292078021 0.0159817382129798 0.828244063775459 0.791666666666667 14.3 14 3 small ovary 2.73682311156183e-09 8.35318710430683e-08 0.827765033085016 0.791208791208791 14.3 14 3 abnormal blood circulation 4.67386098817297e-05 0.000557612911658526 0.827230301151499 0.790697674418605 14.3 14 3 decreased threshold for auditory brainstem response 0.000139234382103358 0.0014864614827558 0.825949758889654 0.789473684210526 14.3 14 3 small superior vagus ganglion 0.0073537671976955 0.0403362643975029 0.825949758889654 0.789473684210526 14.3 14 3 stereotypic behavior 0.0073537671976955 0.0403362643975029 0.825949758889654 0.789473684210526 14.3 14 3 delayed sexual maturation 0.0073537671976955 0.0403362643975029 0.825949758889654 0.789473684210526 14.3 14 3 decreased tumor incidence 0.0073537671976955 0.0403362643975029 0.825949758889654 0.789473684210526 14.3 14 3 abnormal nasal septum morphology 0.0073537671976955 0.0403362643975029 0.825949758889654 0.789473684210526 14.3 14 3 abnormal neural crest cell migration 0.0073537671976955 0.0403362643975029 0.825949758889654 0.789473684210526 14.3 14 3 increased liver adenoma incidence 0.0073537671976955 0.0403362643975029 0.825949758889654 0.789473684210526 14.3 14 3 abnormal sternebra morphology 0.0073537671976955 0.0403362643975029 0.825949758889654 0.789473684210526 14.3 14 3 absent amnion 0.0073537671976955 0.0403362643975029 0.825949758889654 0.789473684210526 14.3 14 3 Leydig cell hypoplasia 0.0073537671976955 0.0403362643975029 0.825949758889654 0.789473684210526 14.3 14 3 decreased fertilization frequency 0.0073537671976955 0.0403362643975029 0.825949758889654 0.789473684210526 14.3 14 3 decreased circulating magnesium level 0.0073537671976955 0.0403362643975029 0.825949758889654 0.789473684210526 14.3 14 3 shortened RR interval 0.0073537671976955 0.0403362643975029 0.825949758889654 0.789473684210526 14.3 14 3 right-sided stomach 0.0073537671976955 0.0403362643975029 0.825949758889654 0.789473684210526 14.3 14 3 embryonic lethality between implantation and somite formation, incomplete penetrance 0.0073537671976955 0.0403362643975029 0.825949758889654 0.789473684210526 14.3 14 3 abnormal snout morphology 8.74198305602306e-06 0.000128672679596789 0.82489084894236 0.788461538461538 14.3 14 3 eyelids open at birth 8.74198305602306e-06 0.000128672679596789 0.82489084894236 0.788461538461538 14.3 14 3 decreased body length 1.21377670515414e-24 2.23649596597847e-22 0.824743992818282 0.788321167883212 14.3 14 3 increased mean corpuscular hemoglobin 8.66480167911852e-10 2.83601239168517e-08 0.82428117351816 0.787878787878788 14.3 14 3 abnormal skin morphology 5.66600517879922e-07 1.12753503058105e-05 0.82428117351816 0.787878787878788 14.3 14 3 abnormal aorta morphology 0.000417678734897607 0.00374405712813621 0.82428117351816 0.787878787878788 14.3 14 3 dextrocardia 0.000417678734897607 0.00374405712813621 0.82428117351816 0.787878787878788 14.3 14 3 decreased brown adipose tissue amount 0.000417678734897607 0.00374405712813621 0.82428117351816 0.787878787878788 14.3 14 3 increased cardiomyocyte apoptosis 0.000417678734897607 0.00374405712813621 0.82428117351816 0.787878787878788 14.3 14 3 abnormal locomotor coordination 0.000417678734897607 0.00374405712813621 0.82428117351816 0.787878787878788 14.3 14 3 abnormal QRS complex 0.000417678734897607 0.00374405712813621 0.82428117351816 0.787878787878788 14.3 14 3 anemia 4.12518873903866e-19 4.66427590379939e-17 0.823079159411681 0.786729857819905 14.3 14 3 delayed bone ossification 1.08663460008484e-07 2.57428911210575e-06 0.823013048635824 0.786666666666667 14.3 14 3 cyanosis 1.72195423831533e-17 1.58643006215162e-15 0.822795089671673 0.786458333333333 14.3 14 3 abnormal eye development 4.84419123828309e-06 7.62653525647417e-05 0.822016664799704 0.785714285714286 14.3 14 3 straub tail 0.0012644216581579 0.00945939511178277 0.822016664799704 0.785714285714286 14.3 14 3 abnormal renal tubule epithelium morphology 0.0012644216581579 0.00945939511178277 0.822016664799704 0.785714285714286 14.3 14 3 abnormal interparietal bone morphology 0.0235654383860015 0.100032470964469 0.822016664799704 0.785714285714286 14.3 14 3 megacephaly 0.0235654383860015 0.100032470964469 0.822016664799704 0.785714285714286 14.3 14 3 abnormal spleen periarteriolar lymphoid sheath morphology 0.0235654383860015 0.100032470964469 0.822016664799704 0.785714285714286 14.3 14 3 vascular smooth muscle hypoplasia 0.0235654383860015 0.100032470964469 0.822016664799704 0.785714285714286 14.3 14 3 abnormal maternal decidual layer morphology 0.0235654383860015 0.100032470964469 0.822016664799704 0.785714285714286 14.3 14 3 abnormal viscerocranium morphology 0.0235654383860015 0.100032470964469 0.822016664799704 0.785714285714286 14.3 14 3 spina bifida occulta 0.0235654383860015 0.100032470964469 0.822016664799704 0.785714285714286 14.3 14 3 increased pulmonary respiratory rate 0.0235654383860015 0.100032470964469 0.822016664799704 0.785714285714286 14.3 14 3 sternebra fusion 0.0235654383860015 0.100032470964469 0.822016664799704 0.785714285714286 14.3 14 3 decreased compact bone area 0.0235654383860015 0.100032470964469 0.822016664799704 0.785714285714286 14.3 14 3 abnormal respiratory motile cilium physiology 0.0235654383860015 0.100032470964469 0.822016664799704 0.785714285714286 14.3 14 3 domed cranium 3.15921672503955e-07 6.83352313350945e-06 0.822016664799703 0.785714285714286 14.3 14 3 abnormal pancreas morphology 7.63318122508002e-05 0.000863069922608479 0.822016664799703 0.785714285714286 14.3 14 3 hunched posture 6.07067620073025e-08 1.50256786560363e-06 0.82107073077807 0.784810126582278 14.3 14 3 abnormal placenta morphology 6.07067620073025e-08 1.50256786560363e-06 0.82107073077807 0.784810126582278 14.3 14 3 abnormal cervical vertebrae morphology 1.42220359375509e-05 0.000197638627903116 0.820551394452467 0.784313725490196 14.3 14 3 small lung 1.42220359375509e-05 0.000197638627903116 0.820551394452467 0.784313725490196 14.3 14 3 abnormal branching of the mammary ductal tree 0.000227264225662829 0.0022433323862551 0.819996967834594 0.783783783783784 14.3 14 3 abnormal breathing pattern 0.000227264225662829 0.0022433323862551 0.819996967834594 0.783783783783784 14.3 14 3 increased erythroid progenitor cell number 0.000227264225662829 0.0022433323862551 0.819996967834594 0.783783783783784 14.3 14 3 decreased width of hypertrophic chondrocyte zone 0.000227264225662829 0.0022433323862551 0.819996967834594 0.783783783783784 14.3 14 3 increased erythrocyte cell number 2.68462302570028e-06 4.46688948256151e-05 0.819525705209401 0.783333333333333 14.3 14 3 muscular ventricular septal defect 2.68462302570028e-06 4.46688948256151e-05 0.819525705209401 0.783333333333333 14.3 14 3 abnormal myelin sheath morphology 4.18976660044217e-05 0.000508392410663409 0.818767587073223 0.782608695652174 14.3 14 3 atrial septal defect 4.18976660044217e-05 0.000508392410663409 0.818767587073223 0.782608695652174 14.3 14 3 abnormal blood vessel physiology 0.00387531053211715 0.0236270464427486 0.818767587073223 0.782608695652174 14.3 14 3 abnormal carpal bone morphology 0.00387531053211715 0.0236270464427486 0.818767587073223 0.782608695652174 14.3 14 3 abnormal circulating insulin level 0.00387531053211715 0.0236270464427486 0.818767587073223 0.782608695652174 14.3 14 3 abnormal corneal stroma morphology 0.00387531053211715 0.0236270464427486 0.818767587073223 0.782608695652174 14.3 14 3 abnormal basicranium morphology 0.00387531053211715 0.0236270464427486 0.818767587073223 0.782608695652174 14.3 14 3 perimembraneous ventricular septal defect 5.11508961471998e-07 1.02199079651534e-05 0.818767587073223 0.782608695652174 14.3 14 3 absent gastric milk in neonates 9.81368550283143e-08 2.34726372002819e-06 0.818184419276162 0.782051282051282 14.3 14 3 abnormal rostral-caudal axis patterning 7.85147099694113e-06 0.000118009269515958 0.817940549106482 0.781818181818182 14.3 14 3 decreased lymphocyte cell number 9.4453019112297e-12 4.19556937574712e-10 0.817346115567887 0.78125 14.3 14 3 failure of primitive streak formation 0.000681259289890767 0.00565820528749009 0.817346115567887 0.78125 14.3 14 3 abnormal diaphragm morphology 0.000681259289890767 0.00565820528749009 0.817346115567887 0.78125 14.3 14 3 abnormal lumbar vertebrae morphology 0.000681259289890767 0.00565820528749009 0.817346115567887 0.78125 14.3 14 3 abnormal embryonic hematopoiesis 0.000681259289890767 0.00565820528749009 0.817346115567887 0.78125 14.3 14 3 decreased bone marrow cell number 2.84379812888114e-07 6.17812038916318e-06 0.816898254682644 0.780821917808219 14.3 14 3 seminiferous tubule degeneration 2.84379812888114e-07 6.17812038916318e-06 0.816898254682644 0.780821917808219 14.3 14 3 Leydig cell hyperplasia 0.000123942711547856 0.00133755963112925 0.816548704723431 0.780487804878049 14.3 14 3 abnormal cell differentiation 0.000123942711547856 0.00133755963112925 0.816548704723431 0.780487804878049 14.3 14 3 palatal shelves fail to meet at midline 0.000123942711547856 0.00133755963112925 0.816548704723431 0.780487804878049 14.3 14 3 abnormal hindlimb morphology 2.3024266122533e-05 0.000302231461634833 0.816038361782979 0.78 14.3 14 3 abnormal thoracic vertebrae morphology 4.3370807536451e-06 6.9379346461043e-05 0.815683716688766 0.779661016949153 14.3 14 3 abnormal ovarian follicle morphology 6.77340708621937e-05 0.000778237881153381 0.813713466165363 0.777777777777778 14.3 14 3 irregular heartbeat 6.77340708621937e-05 0.000778237881153381 0.813713466165363 0.777777777777778 14.3 14 3 abnormal cell migration 6.77340708621937e-05 0.000778237881153381 0.813713466165363 0.777777777777778 14.3 14 3 abnormal limb bone morphology 0.000368529392872933 0.00340154680805722 0.813713466165363 0.777777777777778 14.3 14 3 abnormal thyroid cartilage morphology 0.0120888791174881 0.0604443955874404 0.813713466165363 0.777777777777778 14.3 14 3 abnormal thymus cortex morphology 0.0120888791174881 0.0604443955874404 0.813713466165363 0.777777777777778 14.3 14 3 abnormal metacarpal bone morphology 0.0120888791174881 0.0604443955874404 0.813713466165363 0.777777777777778 14.3 14 3 absent allantois 0.0120888791174881 0.0604443955874404 0.813713466165363 0.777777777777778 14.3 14 3 abnormal redox activity 0.0120888791174881 0.0604443955874404 0.813713466165363 0.777777777777778 14.3 14 3 decreased cellular sensitivity to gamma-irradiation 0.0120888791174881 0.0604443955874404 0.813713466165363 0.777777777777778 14.3 14 3 increased circulating renin level 0.0120888791174881 0.0604443955874404 0.813713466165363 0.777777777777778 14.3 14 3 abnormal anterior eye segment morphology 0.0120888791174881 0.0604443955874404 0.813713466165363 0.777777777777778 14.3 14 3 abnormal eye anterior chamber morphology 0.0120888791174881 0.0604443955874404 0.813713466165363 0.777777777777778 14.3 14 3 darkened coat color 0.0120888791174881 0.0604443955874404 0.813713466165363 0.777777777777778 14.3 14 3 decreased pulmonary respiratory rate 0.0120888791174881 0.0604443955874404 0.813713466165363 0.777777777777778 14.3 14 3 primary atelectasis 0.0120888791174881 0.0604443955874404 0.813713466165363 0.777777777777778 14.3 14 3 abnormal metanephric mesenchyme morphology 0.0120888791174881 0.0604443955874404 0.813713466165363 0.777777777777778 14.3 14 3 heart hyperplasia 0.0791967674343503 0.23522621969307 0.813713466165363 0.777777777777778 14.3 14 3 thick tail 0.0791967674343503 0.23522621969307 0.813713466165363 0.777777777777778 14.3 14 3 abnormal sympathetic neuron morphology 0.0791967674343503 0.23522621969307 0.813713466165363 0.777777777777778 14.3 14 3 abnormal geniculate ganglion morphology 0.0791967674343503 0.23522621969307 0.813713466165363 0.777777777777778 14.3 14 3 dilated uterus 0.0791967674343503 0.23522621969307 0.813713466165363 0.777777777777778 14.3 14 3 abnormal lens vesicle development 0.0791967674343503 0.23522621969307 0.813713466165363 0.777777777777778 14.3 14 3 abnormal germ cell morphology 0.0791967674343503 0.23522621969307 0.813713466165363 0.777777777777778 14.3 14 3 abnormal laryngeal cartilage morphology 0.0791967674343503 0.23522621969307 0.813713466165363 0.777777777777778 14.3 14 3 abnormal thymus lobule morphology 0.0791967674343503 0.23522621969307 0.813713466165363 0.777777777777778 14.3 14 3 priapism 0.0791967674343503 0.23522621969307 0.813713466165363 0.777777777777778 14.3 14 3 premature bone ossification 0.0791967674343503 0.23522621969307 0.813713466165363 0.777777777777778 14.3 14 3 premature neuronal precursor differentiation 0.0791967674343503 0.23522621969307 0.813713466165363 0.777777777777778 14.3 14 3 decreased fear-related response 0.0791967674343503 0.23522621969307 0.813713466165363 0.777777777777778 14.3 14 3 abnormal bony labyrinth 0.0791967674343503 0.23522621969307 0.813713466165363 0.777777777777778 14.3 14 3 decreased cochlear hair cell number 0.0791967674343503 0.23522621969307 0.813713466165363 0.777777777777778 14.3 14 3 abnormal CNS synapse formation 0.0791967674343503 0.23522621969307 0.813713466165363 0.777777777777778 14.3 14 3 decreased thyroid-stimulating hormone level 0.0791967674343503 0.23522621969307 0.813713466165363 0.777777777777778 14.3 14 3 abnormal posterior eye segment morphology 0.0791967674343503 0.23522621969307 0.813713466165363 0.777777777777778 14.3 14 3 abnormal inguinal fat pad morphology 0.0791967674343503 0.23522621969307 0.813713466165363 0.777777777777778 14.3 14 3 decreased susceptibility to atherosclerosis 0.0791967674343503 0.23522621969307 0.813713466165363 0.777777777777778 14.3 14 3 absent cervical lymph nodes 0.0791967674343503 0.23522621969307 0.813713466165363 0.777777777777778 14.3 14 3 decreased susceptibility to parasitic infection induced morbidity/mortality 0.0791967674343503 0.23522621969307 0.813713466165363 0.777777777777778 14.3 14 3 abnormal pulmonary alveolar parenchyma morphology 0.0791967674343503 0.23522621969307 0.813713466165363 0.777777777777778 14.3 14 3 decreased pancreatic beta cell proliferation 0.0791967674343503 0.23522621969307 0.813713466165363 0.777777777777778 14.3 14 3 decreased bone trabecular spacing 0.0791967674343503 0.23522621969307 0.813713466165363 0.777777777777778 14.3 14 3 increased cardiac muscle glycogen level 0.0791967674343503 0.23522621969307 0.813713466165363 0.777777777777778 14.3 14 3 decreased fatty acid oxidation 0.0791967674343503 0.23522621969307 0.813713466165363 0.777777777777778 14.3 14 3 cerebellum atrophy 0.0791967674343503 0.23522621969307 0.813713466165363 0.777777777777778 14.3 14 3 adipose tissue inflammation 0.0791967674343503 0.23522621969307 0.813713466165363 0.777777777777778 14.3 14 3 short snout 6.39843468225959e-10 2.16545663566268e-08 0.813713466165363 0.777777777777778 14.3 14 3 abnormal maxilla morphology 1.26667920129301e-05 0.000179536439499507 0.813713466165363 0.777777777777778 14.3 14 3 thin epidermis 0.00206033395473112 0.0141852423068311 0.813713466165363 0.777777777777778 14.3 14 3 increased brain weight 0.00206033395473112 0.0141852423068311 0.813713466165363 0.777777777777778 14.3 14 3 abnormal brain commissure morphology 0.00206033395473112 0.0141852423068311 0.813713466165363 0.777777777777778 14.3 14 3 decreased bone ossification 0.00206033395473112 0.0141852423068311 0.813713466165363 0.777777777777778 14.3 14 3 abnormal eye morphology 2.66904343811594e-12 1.31470208956701e-10 0.812877172777732 0.776978417266187 14.3 14 3 neonatal lethality, incomplete penetrance 9.77686059454532e-22 1.35110781827397e-19 0.812819275543203 0.776923076923077 14.3 14 3 cataract 6.97462890550133e-11 2.7108420941304e-09 0.812752765496927 0.776859504132231 14.3 14 3 abnormal lung development 4.88920416740783e-08 1.2538036460234e-06 0.812345880507942 0.776470588235294 14.3 14 3 polydactyly 5.26976011653407e-09 1.56988362753036e-07 0.811341123698409 0.775510204081633 14.3 14 3 increased circulating LDL cholesterol level 3.70844838435378e-05 0.000463556048044222 0.811341123698409 0.775510204081633 14.3 14 3 limb grasping 1.98751942895727e-15 1.4330303129076e-13 0.810519928229078 0.774725274725275 14.3 14 3 respiratory distress 1.0109518679379e-14 6.88970622327544e-13 0.810353790417364 0.774566473988439 14.3 14 3 absent mature ovarian follicles 0.00110283095299426 0.00836369510845492 0.809963634524048 0.774193548387097 14.3 14 3 abnormal postnatal growth/weight/body size 0.00110283095299426 0.00836369510845492 0.809963634524048 0.774193548387097 14.3 14 3 abnormal retinal photoreceptor layer morphology 0.00110283095299426 0.00836369510845492 0.809963634524048 0.774193548387097 14.3 14 3 small cranium 0.00110283095299426 0.00836369510845492 0.809963634524048 0.774193548387097 14.3 14 3 decreased hematocrit 1.33501679777388e-12 6.84712223600521e-11 0.809732480518762 0.773972602739726 14.3 14 3 abnormal nervous system physiology 3.1888696678897e-10 1.14134004300369e-08 0.809670169439076 0.773913043478261 14.3 14 3 decreased leukocyte cell number 6.81003254400606e-12 3.07999199149365e-10 0.80947095591424 0.773722627737226 14.3 14 3 abnormal limb morphology 4.06160674258859e-07 8.45459980936328e-06 0.809063674930132 0.773333333333333 14.3 14 3 abnormal chorion morphology 0.00630579177087429 0.0360589816782754 0.808429612488965 0.772727272727273 14.3 14 3 abnormal retinal outer plexiform layer morphology 0.00630579177087429 0.0360589816782754 0.808429612488965 0.772727272727273 14.3 14 3 abnormal cerebral cortex pyramidal cell morphology 0.00630579177087429 0.0360589816782754 0.808429612488965 0.772727272727273 14.3 14 3 decreased brain weight 1.11691750509891e-05 0.000160597242423903 0.807595319803218 0.771929824561403 14.3 14 3 spleen hypoplasia 2.60589617457073e-09 8.00267498054901e-08 0.807070907257891 0.771428571428571 14.3 14 3 abnormal dermal layer morphology 0.000593479435196867 0.00498743275355475 0.807070907257891 0.771428571428571 14.3 14 3 ovary cysts 0.000593479435196867 0.00498743275355475 0.807070907257891 0.771428571428571 14.3 14 3 abnormal phalanx morphology 5.94135648733517e-05 0.000689003462109382 0.806448167360315 0.770833333333333 14.3 14 3 abnormal intestine morphology 6.4744852500717e-07 1.26315937721987e-05 0.805859089078825 0.77027027027027 14.3 14 3 prenatal lethality, incomplete penetrance 5.96249645385478e-24 9.56884511546049e-22 0.805301014917413 0.769736842105263 14.3 14 3 decreased bone mineral content 8.6180578382762e-17 7.52190135884633e-15 0.804771559943766 0.769230769230769 14.3 14 3 heart inflammation 0.00332754194379779 0.0205902004606891 0.804771559943766 0.769230769230769 14.3 14 3 abnormal Mullerian duct morphology 0.00332754194379779 0.0205902004606891 0.804771559943766 0.769230769230769 14.3 14 3 abnormal nerve conduction 0.00332754194379779 0.0205902004606891 0.804771559943766 0.769230769230769 14.3 14 3 short premaxilla 0.0387493502556044 0.142271599646961 0.804771559943766 0.769230769230769 14.3 14 3 absent teeth 0.0387493502556044 0.142271599646961 0.804771559943766 0.769230769230769 14.3 14 3 abnormal renal/urinary system morphology 0.0387493502556044 0.142271599646961 0.804771559943766 0.769230769230769 14.3 14 3 increased foot pad pigmentation 0.0387493502556044 0.142271599646961 0.804771559943766 0.769230769230769 14.3 14 3 tight skin 0.0387493502556044 0.142271599646961 0.804771559943766 0.769230769230769 14.3 14 3 increased pituitary adenoma incidence 0.0387493502556044 0.142271599646961 0.804771559943766 0.769230769230769 14.3 14 3 abnormal pulmonary alveolus epithelial cell morphology 0.0387493502556044 0.142271599646961 0.804771559943766 0.769230769230769 14.3 14 3 increased synaptic depression 0.0387493502556044 0.142271599646961 0.804771559943766 0.769230769230769 14.3 14 3 abnormal bile duct development 0.0387493502556044 0.142271599646961 0.804771559943766 0.769230769230769 14.3 14 3 abnormal coping response 0.0387493502556044 0.142271599646961 0.804771559943766 0.769230769230769 14.3 14 3 muscle fatigue 0.0387493502556044 0.142271599646961 0.804771559943766 0.769230769230769 14.3 14 3 abnormal vestibulocochlear ganglion morphology 0.0387493502556044 0.142271599646961 0.804771559943766 0.769230769230769 14.3 14 3 small otic vesicle 0.0387493502556044 0.142271599646961 0.804771559943766 0.769230769230769 14.3 14 3 small interparietal bone 0.0387493502556044 0.142271599646961 0.804771559943766 0.769230769230769 14.3 14 3 increased prostaglandin level 0.0387493502556044 0.142271599646961 0.804771559943766 0.769230769230769 14.3 14 3 small spleen 3.83429702117439e-08 1.00398040422856e-06 0.804771559943766 0.769230769230769 14.3 14 3 impaired coordination 6.98700236277184e-27 1.65525413118047e-24 0.804306374070966 0.76878612716763 14.3 14 3 neonatal lethality, complete penetrance 1.09992161874598e-34 3.81221909067572e-32 0.803006710031608 0.767543859649123 14.3 14 3 delayed endochondral bone ossification 0.000173989380068731 0.00178302750419264 0.802899998176455 0.767441860465116 14.3 14 3 abnormal eating behavior 9.7665847168923e-06 0.000142224187638236 0.802088988077287 0.766666666666667 14.3 14 3 abnormal heart tube morphology 0.00177098338396481 0.0124093554017252 0.802088988077287 0.766666666666667 14.3 14 3 abnormal optic cup morphology 0.00177098338396481 0.0124093554017252 0.802088988077287 0.766666666666667 14.3 14 3 abnormal cellular respiration 0.00177098338396481 0.0124093554017252 0.802088988077287 0.766666666666667 14.3 14 3 decreased bone trabecula number 9.46595124440022e-05 0.00104188290798432 0.801347000114218 0.765957446808511 14.3 14 3 abnormal tooth morphology 5.36686836785628e-06 8.35180674259795e-05 0.800999193256529 0.765625 14.3 14 3 lung hemorrhage 0.000948753772307147 0.00727280434087528 0.800037609591156 0.764705882352941 14.3 14 3 thin skin 0.000948753772307147 0.00727280434087528 0.800037609591156 0.764705882352941 14.3 14 3 abnormal vagus nerve morphology 0.0196266803252322 0.0858020515096926 0.800037609591156 0.764705882352941 14.3 14 3 increased incidence of corneal inflammation 0.0196266803252322 0.0858020515096926 0.800037609591156 0.764705882352941 14.3 14 3 abnormal heart rate 0.0196266803252322 0.0858020515096926 0.800037609591156 0.764705882352941 14.3 14 3 abnormal involuntary movement 0.0196266803252322 0.0858020515096926 0.800037609591156 0.764705882352941 14.3 14 3 abnormal ectoplacental cone morphology 0.0196266803252322 0.0858020515096926 0.800037609591156 0.764705882352941 14.3 14 3 abnormal tarsal bone morphology 0.0196266803252322 0.0858020515096926 0.800037609591156 0.764705882352941 14.3 14 3 coloboma 0.0196266803252322 0.0858020515096926 0.800037609591156 0.764705882352941 14.3 14 3 common atrium 0.0196266803252322 0.0858020515096926 0.800037609591156 0.764705882352941 14.3 14 3 abnormal frontal bone morphology 0.000510915943798898 0.00435240893904027 0.798418100259999 0.763157894736842 14.3 14 3 persistence of hyaloid vascular system 0.000510915943798898 0.00435240893904027 0.798418100259999 0.763157894736842 14.3 14 3 impaired branching involved in ureteric bud morphogenesis 0.000510915943798898 0.00435240893904027 0.798418100259999 0.763157894736842 14.3 14 3 hyporesponsive to tactile stimuli 0.000510915943798898 0.00435240893904027 0.798418100259999 0.763157894736842 14.3 14 3 increased hemoglobin content 1.54578108682796e-05 0.000213026617921582 0.797951461978141 0.76271186440678 14.3 14 3 ataxia 1.32846494424109e-15 9.86434790686482e-14 0.797600328221495 0.762376237623762 14.3 14 3 abnormal heart morphology 1.41809609048252e-17 1.35673616349049e-15 0.797107068896682 0.761904761904762 14.3 14 3 increased circulating aspartate transaminase level 8.48007874133635e-06 0.000125935497725816 0.797107068896682 0.761904761904762 14.3 14 3 abnormal optic nerve morphology 0.000276297589298431 0.00267949416522358 0.797107068896682 0.761904761904762 14.3 14 3 skin edema 0.000276297589298431 0.00267949416522358 0.797107068896682 0.761904761904762 14.3 14 3 abnormal eye pigmentation 0.0101499816526421 0.0519507805780809 0.797107068896682 0.761904761904762 14.3 14 3 abnormal anxiety-related response 0.0101499816526421 0.0519507805780809 0.797107068896682 0.761904761904762 14.3 14 3 trunk curl 0.0101499816526421 0.0519507805780809 0.797107068896682 0.761904761904762 14.3 14 3 abnormal associative learning 0.0101499816526421 0.0519507805780809 0.797107068896682 0.761904761904762 14.3 14 3 abnormal embryonic/fetal subventricular zone morphology 0.0101499816526421 0.0519507805780809 0.797107068896682 0.761904761904762 14.3 14 3 decreased vocalization 0.0101499816526421 0.0519507805780809 0.797107068896682 0.761904761904762 14.3 14 3 respiratory failure 5.73739042265096e-12 2.64291827339709e-10 0.796777140474126 0.76158940397351 14.3 14 3 abnormal suckling behavior 1.51133932898377e-07 3.49716891241594e-06 0.796540941717068 0.761363636363636 14.3 14 3 internal hemorrhage 4.65894324615656e-06 7.35817226972345e-05 0.796363498869726 0.761194029850746 14.3 14 3 perinatal lethality, incomplete penetrance 3.99016810688418e-17 3.54483684495514e-15 0.796225313289496 0.761061946902655 14.3 14 3 retinal degeneration 4.62704547446355e-08 1.19893496018001e-06 0.795550219152743 0.760416666666667 14.3 14 3 decreased respiratory quotient 8.16085066267203e-05 0.000918557286126547 0.795114301224441 0.76 14.3 14 3 ruffled hair 0.00532288830265055 0.0308640667898444 0.795114301224441 0.76 14.3 14 3 mandible hypoplasia 0.00532288830265055 0.0308640667898444 0.795114301224441 0.76 14.3 14 3 abnormal keratinocyte physiology 0.00532288830265055 0.0308640667898444 0.795114301224441 0.76 14.3 14 3 abnormal cochlear outer hair cell morphology 0.00532288830265055 0.0308640667898444 0.795114301224441 0.76 14.3 14 3 decreased B cell proliferation 7.78194971643238e-07 1.43389629034263e-05 0.794584578172326 0.759493670886076 14.3 14 3 female infertility 1.15479762443714e-19 1.36788528132733e-17 0.794485006170048 0.759398496240602 14.3 14 3 abnormal chondrocyte morphology 4.45280846912598e-05 0.000532517358988022 0.794339336018569 0.759259259259259 14.3 14 3 increased cell proliferation 4.45280846912598e-05 0.000532517358988022 0.794339336018569 0.759259259259259 14.3 14 3 abnormal spermiogenesis 2.43480455658682e-05 0.000318767175500511 0.793671262565231 0.758620689655172 14.3 14 3 focal hair loss 0.00281961587655055 0.0183204804796714 0.793671262565231 0.758620689655172 14.3 14 3 abnormal blood vessel morphology 2.53009627148061e-11 1.06671431784882e-09 0.793671262565231 0.758620689655172 14.3 14 3 decreased birth weight 7.24994176759387e-08 1.76806177910684e-06 0.792911768534068 0.757894736842105 14.3 14 3 abnormal vascular development 7.31895017187046e-06 0.000110338718500168 0.792578051459769 0.757575757575758 14.3 14 3 cardiovascular system phenotype 0.0015049485242444 0.0110592598347355 0.792578051459769 0.757575757575758 14.3 14 3 premature death 7.3223463475122e-60 6.07144551314553e-57 0.792246659939995 0.75725900116144 14.3 14 3 abnormal angiogenesis 2.21278453348804e-06 3.77006953907637e-05 0.791721210323056 0.756756756756757 14.3 14 3 abnormal respiratory electron transport chain 0.000808021024193255 0.00648371708929265 0.791721210323056 0.756756756756757 14.3 14 3 increased rib number 1.21885511870922e-06 2.16564436270656e-05 0.79135870061137 0.756410256410256 14.3 14 3 increased circulating alanine transaminase level 1.21885511870922e-06 2.16564436270656e-05 0.79135870061137 0.756410256410256 14.3 14 3 sparse hair 6.72055325420319e-07 1.30604501717425e-05 0.791031557700823 0.75609756097561 14.3 14 3 lethality at weaning, incomplete penetrance 0.000435898254382204 0.00390034858912134 0.791031557700823 0.75609756097561 14.3 14 3 increased circulating creatinine level 3.7089691875181e-07 7.93857151428673e-06 0.790734846688933 0.755813953488372 14.3 14 3 thin ventricular wall 2.04860280713993e-07 4.63263589341871e-06 0.79046450998921 0.755555555555556 14.3 14 3 abnormal autopod morphology 0.000236067841604113 0.00232561883560488 0.79046450998921 0.755555555555556 14.3 14 3 cardiac hypertrophy 6.263305734478e-08 1.54257158559545e-06 0.789990041495819 0.755102040816326 14.3 14 3 postnatal growth retardation 4.97818796615484e-42 2.47664851316203e-39 0.789780717160499 0.754901960784314 14.3 14 3 abnormal placenta development 6.98789578381571e-05 0.000797357374414752 0.789587190888223 0.754716981132076 14.3 14 3 increased circulating bilirubin level 6.98789578381571e-05 0.000797357374414752 0.789587190888223 0.754716981132076 14.3 14 3 seizures 5.89538855048185e-09 1.74580702610995e-07 0.789240880716781 0.754385964912281 14.3 14 3 abnormal maternal nurturing 2.08814835105419e-05 0.000279261775443403 0.788939988272741 0.754098360655738 14.3 14 3 increased double-negative T cell number 2.08814835105419e-05 0.000279261775443403 0.788939988272741 0.754098360655738 14.3 14 3 hypoactivity 4.43845854382018e-26 9.20055468979392e-24 0.788121113875964 0.753315649867374 14.3 14 3 reduced male fertility 2.78451881673603e-16 2.19888589099393e-14 0.788108888878851 0.753303964757709 14.3 14 3 decreased heart weight 1.04790724430663e-06 1.89575946924563e-05 0.787881292636304 0.753086419753086 14.3 14 3 abnormal spleen morphology 8.75623934534859e-13 4.63428624926694e-11 0.787658601485191 0.752873563218391 14.3 14 3 increased startle reflex 3.19080721980639e-07 6.87197658811116e-06 0.787591043495528 0.752808988764045 14.3 14 3 increased circulating HDL cholesterol level 2.98494649184514e-08 7.94123465076449e-07 0.787143230535474 0.752380952380952 14.3 14 3 decreased body weight 1.00889428242344e-81 1.72256639078526e-78 0.785074808517032 0.750403877221325 14.3 14 3 decreased circulating alanine transaminase level 9.7770195321159e-06 0.000142224187638236 0.784652270945172 0.75 14.3 14 3 abnormal lens morphology 1.34325904937769e-09 4.28379087862436e-08 0.784652270945172 0.75 14.3 14 3 abnormal coat/hair pigmentation 1.4196875866911e-08 4.01303735442513e-07 0.784652270945172 0.75 14.3 14 3 abnormal neuron differentiation 1.4196875866911e-08 4.01303735442513e-07 0.784652270945172 0.75 14.3 14 3 abnormal digit morphology 5.37201639724893e-06 8.35180674259795e-05 0.784652270945172 0.75 14.3 14 3 abnormal kidney development 3.25314893224415e-05 0.00041306442256464 0.784652270945172 0.75 14.3 14 3 epidermal hyperplasia 3.25314893224415e-05 0.00041306442256464 0.784652270945172 0.75 14.3 14 3 intracranial hemorrhage 3.25314893224415e-05 0.00041306442256464 0.784652270945172 0.75 14.3 14 3 abnormal female reproductive system morphology 0.000682969744054463 0.00566295746111826 0.784652270945172 0.75 14.3 14 3 short radius 0.00126832956216867 0.00947438374142516 0.784652270945172 0.75 14.3 14 3 abnormal vertebral body morphology 0.00236754594230474 0.0159817382129798 0.784652270945172 0.75 14.3 14 3 abnormal depression-related behavior 0.00236754594230474 0.0159817382129798 0.784652270945172 0.75 14.3 14 3 increased fatty acid level 0.00236754594230474 0.0159817382129798 0.784652270945172 0.75 14.3 14 3 lymphoid hyperplasia 0.00444807084445074 0.0267583463738119 0.784652270945172 0.75 14.3 14 3 abnormal somite shape 0.00444807084445074 0.0267583463738119 0.784652270945172 0.75 14.3 14 3 absent corpus callosum 0.00444807084445074 0.0267583463738119 0.784652270945172 0.75 14.3 14 3 abnormal retinal inner nuclear layer morphology 0.00444807084445074 0.0267583463738119 0.784652270945172 0.75 14.3 14 3 abnormal basioccipital bone morphology 0.0161448331176242 0.0732637664313417 0.784652270945172 0.75 14.3 14 3 increased urine glucose level 0.0161448331176242 0.0732637664313417 0.784652270945172 0.75 14.3 14 3 anencephaly 0.0161448331176242 0.0732637664313417 0.784652270945172 0.75 14.3 14 3 abnormal thymocyte activation 0.0161448331176242 0.0732637664313417 0.784652270945172 0.75 14.3 14 3 abnormal postnatal subventricular zone morphology 0.0161448331176242 0.0732637664313417 0.784652270945172 0.75 14.3 14 3 dilated vasculature 0.0161448331176242 0.0732637664313417 0.784652270945172 0.75 14.3 14 3 abnormal response to tactile stimuli 0.0161448331176242 0.0732637664313417 0.784652270945172 0.75 14.3 14 3 abnormal neuron proliferation 0.0161448331176242 0.0732637664313417 0.784652270945172 0.75 14.3 14 3 abnormal tympanic ring morphology 0.0314240341439958 0.118614999898618 0.784652270945172 0.75 14.3 14 3 vasculature congestion 0.0314240341439958 0.118614999898618 0.784652270945172 0.75 14.3 14 3 decreased mast cell number 0.0314240341439958 0.118614999898618 0.784652270945172 0.75 14.3 14 3 abnormal hair follicle orientation 0.0314240341439958 0.118614999898618 0.784652270945172 0.75 14.3 14 3 delayed hair appearance 0.0314240341439958 0.118614999898618 0.784652270945172 0.75 14.3 14 3 reduced male mating frequency 0.0314240341439958 0.118614999898618 0.784652270945172 0.75 14.3 14 3 poor circulation 0.0314240341439958 0.118614999898618 0.784652270945172 0.75 14.3 14 3 abnormal olfaction 0.0314240341439958 0.118614999898618 0.784652270945172 0.75 14.3 14 3 paternal imprinting 0.0314240341439958 0.118614999898618 0.784652270945172 0.75 14.3 14 3 increased pancreatic beta cell number 0.0314240341439958 0.118614999898618 0.784652270945172 0.75 14.3 14 3 bowed radius 0.0314240341439958 0.118614999898618 0.784652270945172 0.75 14.3 14 3 decreased creatinine clearance 0.0314240341439958 0.118614999898618 0.784652270945172 0.75 14.3 14 3 dilated respiratory conducting tubes 0.0314240341439958 0.118614999898618 0.784652270945172 0.75 14.3 14 3 abnormal pulmonary alveolus wall morphology 0.0314240341439958 0.118614999898618 0.784652270945172 0.75 14.3 14 3 embryonic lethality between somite formation and embryo turning, incomplete penetrance 0.0314240341439958 0.118614999898618 0.784652270945172 0.75 14.3 14 3 decreased adipocyte glucose uptake 0.0314240341439958 0.118614999898618 0.784652270945172 0.75 14.3 14 3 abnormal exoccipital bone morphology 0.130183861125102 0.317016499802927 0.784652270945172 0.75 14.3 14 3 abnormal bone marrow development 0.130183861125102 0.317016499802927 0.784652270945172 0.75 14.3 14 3 pointed snout 0.130183861125102 0.317016499802927 0.784652270945172 0.75 14.3 14 3 clubfoot 0.130183861125102 0.317016499802927 0.784652270945172 0.75 14.3 14 3 enlarged pituitary gland 0.130183861125102 0.317016499802927 0.784652270945172 0.75 14.3 14 3 abnormal pupil morphology 0.130183861125102 0.317016499802927 0.784652270945172 0.75 14.3 14 3 dry eyes 0.130183861125102 0.317016499802927 0.784652270945172 0.75 14.3 14 3 absent eyelids 0.130183861125102 0.317016499802927 0.784652270945172 0.75 14.3 14 3 spinning 0.130183861125102 0.317016499802927 0.784652270945172 0.75 14.3 14 3 preneoplasia 0.130183861125102 0.317016499802927 0.784652270945172 0.75 14.3 14 3 abnormal secondary sex determination 0.130183861125102 0.317016499802927 0.784652270945172 0.75 14.3 14 3 abnormal pulmonary circulation 0.130183861125102 0.317016499802927 0.784652270945172 0.75 14.3 14 3 head spot 0.130183861125102 0.317016499802927 0.784652270945172 0.75 14.3 14 3 short ureter 0.130183861125102 0.317016499802927 0.784652270945172 0.75 14.3 14 3 decreased aerobic running capacity 0.130183861125102 0.317016499802927 0.784652270945172 0.75 14.3 14 3 hypospadia 0.130183861125102 0.317016499802927 0.784652270945172 0.75 14.3 14 3 abnormal cellular cholesterol metabolism 0.130183861125102 0.317016499802927 0.784652270945172 0.75 14.3 14 3 calcified muscle 0.130183861125102 0.317016499802927 0.784652270945172 0.75 14.3 14 3 abnormal neuron apoptosis 0.130183861125102 0.317016499802927 0.784652270945172 0.75 14.3 14 3 abnormal umbilical artery morphology 0.130183861125102 0.317016499802927 0.784652270945172 0.75 14.3 14 3 abnormal perineum morphology 0.130183861125102 0.317016499802927 0.784652270945172 0.75 14.3 14 3 liver cysts 0.130183861125102 0.317016499802927 0.784652270945172 0.75 14.3 14 3 increased cardiac output 0.130183861125102 0.317016499802927 0.784652270945172 0.75 14.3 14 3 abnormal platelet shape 0.130183861125102 0.317016499802927 0.784652270945172 0.75 14.3 14 3 increased left ventricle systolic pressure 0.130183861125102 0.317016499802927 0.784652270945172 0.75 14.3 14 3 abnormal skin development 0.130183861125102 0.317016499802927 0.784652270945172 0.75 14.3 14 3 thin stria vascularis 0.130183861125102 0.317016499802927 0.784652270945172 0.75 14.3 14 3 abnormal vestibular labyrinth morphology 0.130183861125102 0.317016499802927 0.784652270945172 0.75 14.3 14 3 abnormal kidney epithelium morphology 0.130183861125102 0.317016499802927 0.784652270945172 0.75 14.3 14 3 abnormal choroid pigmentation 0.130183861125102 0.317016499802927 0.784652270945172 0.75 14.3 14 3 non-pigmented tail tip 0.130183861125102 0.317016499802927 0.784652270945172 0.75 14.3 14 3 abnormal canal of Schlemm morphology 0.130183861125102 0.317016499802927 0.784652270945172 0.75 14.3 14 3 abnormal olfactory tract morphology 0.130183861125102 0.317016499802927 0.784652270945172 0.75 14.3 14 3 Sertoli cell hypoplasia 0.130183861125102 0.317016499802927 0.784652270945172 0.75 14.3 14 3 ocular hypertension 0.130183861125102 0.317016499802927 0.784652270945172 0.75 14.3 14 3 increased pulmonary ventilation 0.130183861125102 0.317016499802927 0.784652270945172 0.75 14.3 14 3 abnormal mitotic spindle assembly checkpoint 0.130183861125102 0.317016499802927 0.784652270945172 0.75 14.3 14 3 abnormal sphingomyelin level 0.130183861125102 0.317016499802927 0.784652270945172 0.75 14.3 14 3 abnormal frontonasal prominence morphology 0.130183861125102 0.317016499802927 0.784652270945172 0.75 14.3 14 3 decreased serotonin level 0.130183861125102 0.317016499802927 0.784652270945172 0.75 14.3 14 3 abnormal lateral plate mesoderm morphology 0.130183861125102 0.317016499802927 0.784652270945172 0.75 14.3 14 3 abnormal circulating serum amyloid protein level 0.130183861125102 0.317016499802927 0.784652270945172 0.75 14.3 14 3 anomalous pulmonary venous connection 0.130183861125102 0.317016499802927 0.784652270945172 0.75 14.3 14 3 abnormal anterior commissure pars posterior morphology 0.130183861125102 0.317016499802927 0.784652270945172 0.75 14.3 14 3 increased airway resistance 0.130183861125102 0.317016499802927 0.784652270945172 0.75 14.3 14 3 abnormal branching involved in ureteric bud morphogenesis 0.130183861125102 0.317016499802927 0.784652270945172 0.75 14.3 14 3 abnormal macrophage activation involved in immune response 0.130183861125102 0.317016499802927 0.784652270945172 0.75 14.3 14 3 lethality during fetal growth through weaning, incomplete penetrance 0.130183861125102 0.317016499802927 0.784652270945172 0.75 14.3 14 3 absent Reichert's membrane 0.130183861125102 0.317016499802927 0.784652270945172 0.75 14.3 14 3 impaired neuron differentiation 0.130183861125102 0.317016499802927 0.784652270945172 0.75 14.3 14 3 increased cardiac stroke volume 0.130183861125102 0.317016499802927 0.784652270945172 0.75 14.3 14 3 overriding aortic valve 0.000200397355155952 0.00199395368380172 0.784652270945172 0.75 14.3 14 3 abnormal foregut morphology 0.00842696336612798 0.0452744522100288 0.784652270945172 0.75 14.3 14 3 apnea 0.00842696336612798 0.0452744522100288 0.784652270945172 0.75 14.3 14 3 abnormal osteoblast morphology 0.00842696336612798 0.0452744522100288 0.784652270945172 0.75 14.3 14 3 hypopigmentation 0.00842696336612798 0.0452744522100288 0.784652270945172 0.75 14.3 14 3 abnormal mineral level 0.0626526804357307 0.194203791381782 0.784652270945172 0.75 14.3 14 3 amyloidosis 0.0626526804357307 0.194203791381782 0.784652270945172 0.75 14.3 14 3 abnormal glossopharyngeal nerve morphology 0.0626526804357307 0.194203791381782 0.784652270945172 0.75 14.3 14 3 myocarditis 0.0626526804357307 0.194203791381782 0.784652270945172 0.75 14.3 14 3 interstitial pneumonia 0.0626526804357307 0.194203791381782 0.784652270945172 0.75 14.3 14 3 abnormal embryonic growth/weight/body size 0.0626526804357307 0.194203791381782 0.784652270945172 0.75 14.3 14 3 abnormal tracheal ciliated epithelium morphology 0.0626526804357307 0.194203791381782 0.784652270945172 0.75 14.3 14 3 abnormal respiratory function 0.0626526804357307 0.194203791381782 0.784652270945172 0.75 14.3 14 3 abnormal nucleotide metabolism 0.0626526804357307 0.194203791381782 0.784652270945172 0.75 14.3 14 3 decreased left ventricle systolic pressure 0.0626526804357307 0.194203791381782 0.784652270945172 0.75 14.3 14 3 bowed ulna 0.0626526804357307 0.194203791381782 0.784652270945172 0.75 14.3 14 3 small parietal bone 0.0626526804357307 0.194203791381782 0.784652270945172 0.75 14.3 14 3 abnormal thymus corticomedullary boundary morphology 0.0626526804357307 0.194203791381782 0.784652270945172 0.75 14.3 14 3 decreased keratinocyte proliferation 0.0626526804357307 0.194203791381782 0.784652270945172 0.75 14.3 14 3 decreased prostaglandin level 0.0626526804357307 0.194203791381782 0.784652270945172 0.75 14.3 14 3 decreased mammary gland epithelial cell proliferation 0.0626526804357307 0.194203791381782 0.784652270945172 0.75 14.3 14 3 increased skeletal muscle glycogen level 0.0626526804357307 0.194203791381782 0.784652270945172 0.75 14.3 14 3 prenatal growth retardation 0.0626526804357307 0.194203791381782 0.784652270945172 0.75 14.3 14 3 abnormal vitelline vein connection 0.0626526804357307 0.194203791381782 0.784652270945172 0.75 14.3 14 3 decreased grip strength 2.86848896084953e-15 2.03867608288949e-13 0.783457975251191 0.748858447488584 14.3 14 3 increased heart weight 3.55200067271633e-10 1.26222881048313e-08 0.782770610823001 0.748201438848921 14.3 14 3 decreased body size 9.13276894999374e-52 5.67944069077736e-49 0.782685723900196 0.74812030075188 14.3 14 3 abnormal gait 9.66688603564898e-21 1.20231895068384e-18 0.782112943207485 0.747572815533981 14.3 14 3 decreased B cell number 2.56179125286404e-14 1.63396301064085e-12 0.782112943207485 0.747572815533981 14.3 14 3 short limbs 7.66008426698197e-07 1.42847796659709e-05 0.781645940405152 0.747126436781609 14.3 14 3 abnormal myocardium layer morphology 2.51880255255385e-06 4.23346037126871e-05 0.781341501869454 0.746835443037975 14.3 14 3 enlarged spleen 2.78262377067211e-19 3.21943099048692e-17 0.781019621542648 0.746527777777778 14.3 14 3 decreased susceptibility to hepatic steatosis 2.7609600237176e-05 0.000357702503072788 0.780500671628001 0.746031746031746 14.3 14 3 abnormal enzyme/coenzyme activity 4.46466694071288e-11 1.80583073415013e-09 0.779654485779916 0.745222929936306 14.3 14 3 cochlear inner hair cell degeneration 0.000169233561343169 0.00175038870620014 0.779523824729844 0.745098039215686 14.3 14 3 abnormal dendritic spine morphology 0.000169233561343169 0.00175038870620014 0.779523824729844 0.745098039215686 14.3 14 3 postnatal lethality, incomplete penetrance 3.62311901835238e-36 1.38653977817716e-33 0.779126550727248 0.744718309859155 14.3 14 3 decreased hemoglobin content 4.67449401715494e-10 1.62626627519901e-08 0.779087361222156 0.74468085106383 14.3 14 3 neuron degeneration 0.000311177941938245 0.00290998169387739 0.779087361222156 0.74468085106383 14.3 14 3 kidney failure 0.000573921470693925 0.00483942257068183 0.778569695201411 0.744186046511628 14.3 14 3 decreased B-1 B cell number 0.0010623551076219 0.00813110255449071 0.777945841278974 0.743589743589744 14.3 14 3 increased circulating serum albumin level 0.00197510185729242 0.0137236476816058 0.777179392174265 0.742857142857143 14.3 14 3 decreased bone mineralization 0.00197510185729242 0.0137236476816058 0.777179392174265 0.742857142857143 14.3 14 3 abnormal pulmonary alveolus morphology 1.69283223874159e-07 3.86322953566029e-06 0.776883436579378 0.742574257425743 14.3 14 3 decreased circulating HDL cholesterol level 4.18141623820563e-09 1.26076035061049e-07 0.776478809789493 0.7421875 14.3 14 3 osteopetrosis 0.00369192162300514 0.0227037207347967 0.776215149752213 0.741935483870968 14.3 14 3 abnormal cranial ganglia morphology 0.00369192162300514 0.0227037207347967 0.776215149752213 0.741935483870968 14.3 14 3 decreased double-negative T cell number 0.00369192162300514 0.0227037207347967 0.776215149752213 0.741935483870968 14.3 14 3 cochlear ganglion degeneration 7.77562631268071e-05 0.000877182333460012 0.775633279325112 0.741379310344828 14.3 14 3 postnatal lethality, complete penetrance 2.70369920981552e-24 4.48363452294408e-22 0.775165974059824 0.740932642487047 14.3 14 3 abnormal bone structure 7.01229966025187e-13 3.79197726192968e-11 0.775165974059824 0.740932642487047 14.3 14 3 abnormal skeleton development 3.28463132233235e-06 5.37534237783008e-05 0.774965205871774 0.740740740740741 14.3 14 3 abnormal osteoblast physiology 0.00014231002397215 0.0015160436172622 0.774965205871774 0.740740740740741 14.3 14 3 abnormal heart valve morphology 0.00694813619827399 0.0388393006588911 0.774965205871774 0.740740740740741 14.3 14 3 thick interventricular septum 0.00694813619827399 0.0388393006588911 0.774965205871774 0.740740740740741 14.3 14 3 abnormal liver physiology 2.59172236833379e-07 5.73491389113047e-06 0.774190240665903 0.74 14.3 14 3 increased body length 0.000261043345428861 0.00255145509530173 0.774190240665903 0.74 14.3 14 3 short stride length 0.000261043345428861 0.00255145509530173 0.774190240665903 0.74 14.3 14 3 abnormal locomotor behavior 8.46425599478637e-07 1.54814976375229e-05 0.773280498902488 0.739130434782609 14.3 14 3 fragile skeleton 0.0131921552806862 0.0646911728321082 0.773280498902488 0.739130434782609 14.3 14 3 abnormal cranial nerve morphology 0.0131921552806862 0.0646911728321082 0.773280498902488 0.739130434782609 14.3 14 3 failure of embryo implantation 0.0131921552806862 0.0646911728321082 0.773280498902488 0.739130434782609 14.3 14 3 abnormal postnatal growth 0.0131921552806862 0.0646911728321082 0.773280498902488 0.739130434782609 14.3 14 3 abnormal Wolffian duct morphology 0.0131921552806862 0.0646911728321082 0.773280498902488 0.739130434782609 14.3 14 3 abnormal lens development 0.0131921552806862 0.0646911728321082 0.773280498902488 0.739130434782609 14.3 14 3 abnormal palatal shelf fusion at midline 0.0131921552806862 0.0646911728321082 0.773280498902488 0.739130434782609 14.3 14 3 decreased effector memory CD8-positive, alpha-beta T cell number 0.0131921552806862 0.0646911728321082 0.773280498902488 0.739130434782609 14.3 14 3 microphthalmia 2.44386277506901e-10 8.87461117223966e-09 0.77268589644274 0.738562091503268 14.3 14 3 infertility 1.21448952724557e-07 2.86354758201266e-06 0.772430272955371 0.738317757009346 14.3 14 3 impaired glucose tolerance 8.99174095655667e-16 6.77786534225295e-14 0.771996589155733 0.737903225806452 14.3 14 3 decreased circulating cholesterol level 5.24405024323312e-12 2.46124056227215e-10 0.771789118962464 0.737704918032787 14.3 14 3 abnormal social investigation 5.02209916950836e-06 7.88168560514325e-05 0.771574733096085 0.7375 14.3 14 3 abnormal liver morphology 9.40889216444739e-12 4.19556937574712e-10 0.77150167422542 0.737430167597765 14.3 14 3 enlarged heart 9.28615547459575e-15 6.49907945009636e-13 0.771123783515082 0.737068965517241 14.3 14 3 decreased neuron apoptosis 0.00163991524929745 0.0115724515819217 0.770886441630344 0.736842105263158 14.3 14 3 irregular coat pigmentation 0.0253471924929072 0.105790505580716 0.770886441630344 0.736842105263158 14.3 14 3 abnormal nail morphology 0.0253471924929072 0.105790505580716 0.770886441630344 0.736842105263158 14.3 14 3 unresponsive to tactile stimuli 0.0253471924929072 0.105790505580716 0.770886441630344 0.736842105263158 14.3 14 3 decreased germ cell number 0.0253471924929072 0.105790505580716 0.770886441630344 0.736842105263158 14.3 14 3 maternal imprinting 0.0253471924929072 0.105790505580716 0.770886441630344 0.736842105263158 14.3 14 3 oliguria 0.0253471924929072 0.105790505580716 0.770886441630344 0.736842105263158 14.3 14 3 increased left ventricle weight 0.0253471924929072 0.105790505580716 0.770886441630344 0.736842105263158 14.3 14 3 abnormal cochlear inner hair cell morphology 0.0253471924929072 0.105790505580716 0.770886441630344 0.736842105263158 14.3 14 3 abnormal B cell differentiation 1.29061255446628e-06 2.26492670017517e-05 0.77028135023189 0.736263736263736 14.3 14 3 decreased mean corpuscular hemoglobin 3.00466122346758e-05 0.00038826466459094 0.769266932299188 0.735294117647059 14.3 14 3 overexpanded pulmonary alveoli 0.00304993394629232 0.0195284789629287 0.769266932299188 0.735294117647059 14.3 14 3 abnormal endoderm development 0.00304993394629232 0.0195284789629287 0.769266932299188 0.735294117647059 14.3 14 3 abnormal nervous system development 0.00304993394629232 0.0195284789629287 0.769266932299188 0.735294117647059 14.3 14 3 organ of Corti degeneration 0.000400158005607054 0.00364612834779321 0.768638959293229 0.73469387755102 14.3 14 3 decreased circulating creatinine level 0.000400158005607054 0.00364612834779321 0.768638959293229 0.73469387755102 14.3 14 3 increased insulin sensitivity 1.81878481612787e-09 5.76334678995934e-08 0.768191034491777 0.734265734265734 14.3 14 3 cleft secondary palate 1.08562072684011e-06 1.9568706942136e-05 0.767957541776125 0.734042553191489 14.3 14 3 reduced fertility 3.26612894327365e-09 9.90792164194293e-08 0.767717329845635 0.733812949640288 14.3 14 3 emphysema 0.00570335523116133 0.032840500318319 0.767215553813057 0.733333333333333 14.3 14 3 disorganized myocardium 0.00570335523116133 0.032840500318319 0.767215553813057 0.733333333333333 14.3 14 3 decreased salivation 0.0495323456459861 0.171843388834575 0.767215553813057 0.733333333333333 14.3 14 3 hyperpigmentation 0.0495323456459861 0.171843388834575 0.767215553813057 0.733333333333333 14.3 14 3 audiogenic seizures 0.0495323456459861 0.171843388834575 0.767215553813057 0.733333333333333 14.3 14 3 abnormal apical ectodermal ridge morphology 0.0495323456459861 0.171843388834575 0.767215553813057 0.733333333333333 14.3 14 3 absent egg cylinders 0.0495323456459861 0.171843388834575 0.767215553813057 0.733333333333333 14.3 14 3 abnormal bronchus morphology 0.0495323456459861 0.171843388834575 0.767215553813057 0.733333333333333 14.3 14 3 dilated ureter 0.0495323456459861 0.171843388834575 0.767215553813057 0.733333333333333 14.3 14 3 abnormal glial cell morphology 0.0495323456459861 0.171843388834575 0.767215553813057 0.733333333333333 14.3 14 3 abnormal energy homeostasis 0.0495323456459861 0.171843388834575 0.767215553813057 0.733333333333333 14.3 14 3 decreased thymocyte apoptosis 0.0495323456459861 0.171843388834575 0.767215553813057 0.733333333333333 14.3 14 3 bicuspid aortic valve 0.0495323456459861 0.171843388834575 0.767215553813057 0.733333333333333 14.3 14 3 abnormal coronary vessel morphology 0.0495323456459861 0.171843388834575 0.767215553813057 0.733333333333333 14.3 14 3 herniated liver 0.0495323456459861 0.171843388834575 0.767215553813057 0.733333333333333 14.3 14 3 abnormal branching involved in lung morphogenesis 0.0495323456459861 0.171843388834575 0.767215553813057 0.733333333333333 14.3 14 3 decreased brown adipose tissue mass 0.0495323456459861 0.171843388834575 0.767215553813057 0.733333333333333 14.3 14 3 decreased bone mineral density 3.29755350783316e-16 2.56333260960468e-14 0.766953347540393 0.733082706766917 14.3 14 3 short mandible 0.000181862889873114 0.00185783958340605 0.765970074017906 0.732142857142857 14.3 14 3 abnormal mammary gland development 0.00135680107952427 0.0100298445328875 0.765514410678216 0.731707317073171 14.3 14 3 hemopericardium 0.00135680107952427 0.0100298445328875 0.765514410678216 0.731707317073171 14.3 14 3 decreased circulating glucose level 1.10466609910771e-16 9.31476922552684e-15 0.764965654828268 0.731182795698925 14.3 14 3 lethargy 1.64421015855828e-06 2.86012081777184e-05 0.764965654828268 0.731182795698925 14.3 14 3 cachexia 4.24214970122672e-07 8.79362281816788e-06 0.764532981946577 0.730769230769231 14.3 14 3 abnormal xiphoid process morphology 0.0107388284195366 0.054683389342062 0.764532981946577 0.730769230769231 14.3 14 3 thick skin 0.0107388284195366 0.054683389342062 0.764532981946577 0.730769230769231 14.3 14 3 increased susceptibility to otitis media 0.0107388284195366 0.054683389342062 0.764532981946577 0.730769230769231 14.3 14 3 enlarged liver 7.64016809851982e-07 1.42847796659709e-05 0.763728210386634 0.73 14.3 14 3 impaired skeletal muscle contractility 0.0025111626147023 0.0167097897766113 0.763445452811518 0.72972972972973 14.3 14 3 decreased circulating chloride level 0.0025111626147023 0.0167097897766113 0.763445452811518 0.72972972972973 14.3 14 3 abnormal hair follicle development 0.0025111626147023 0.0167097897766113 0.763445452811518 0.72972972972973 14.3 14 3 abnormal humerus morphology 0.0025111626147023 0.0167097897766113 0.763445452811518 0.72972972972973 14.3 14 3 circling 5.3583947251626e-06 8.35180674259795e-05 0.763112796840794 0.729411764705882 14.3 14 3 abnormal retina morphology 1.13385545059034e-12 5.87596965279889e-11 0.762233634632452 0.728571428571429 14.3 14 3 hyperactivity 4.03065510855034e-21 5.41959707163188e-19 0.761387648356501 0.727762803234501 14.3 14 3 small kidney 4.47376455887302e-06 7.11085580843235e-05 0.760874929401378 0.727272727272727 14.3 14 3 abnormal tail morphology 6.90699461558323e-05 0.000791758023330105 0.760874929401378 0.727272727272727 14.3 14 3 decreased circulating calcium level 0.000275734591607394 0.00267949416522358 0.760874929401378 0.727272727272727 14.3 14 3 abnormal platelet physiology 0.000275734591607394 0.00267949416522358 0.760874929401378 0.727272727272727 14.3 14 3 abnormal myelopoiesis 0.00111955061260411 0.00842626973934257 0.760874929401378 0.727272727272727 14.3 14 3 abnormal gametogenesis 0.00111955061260411 0.00842626973934257 0.760874929401378 0.727272727272727 14.3 14 3 muscular atrophy 0.00111955061260411 0.00842626973934257 0.760874929401378 0.727272727272727 14.3 14 3 abnormal epidermis stratum basale morphology 0.00466780572379898 0.0279114585046874 0.760874929401378 0.727272727272727 14.3 14 3 increased osteoblast cell number 0.00466780572379898 0.0279114585046874 0.760874929401378 0.727272727272727 14.3 14 3 myeloid hyperplasia 0.00466780572379898 0.0279114585046874 0.760874929401378 0.727272727272727 14.3 14 3 abnormal abdominal fat pad morphology 0.0204011546706898 0.0887200563694769 0.760874929401378 0.727272727272727 14.3 14 3 abnormal long bone epiphysis morphology 0.0204011546706898 0.0887200563694769 0.760874929401378 0.727272727272727 14.3 14 3 abnormal facial nerve morphology 0.0204011546706898 0.0887200563694769 0.760874929401378 0.727272727272727 14.3 14 3 abnormal temporal bone morphology 0.0204011546706898 0.0887200563694769 0.760874929401378 0.727272727272727 14.3 14 3 absent semicircular canals 0.0993407077003097 0.27610057028438 0.760874929401378 0.727272727272727 14.3 14 3 abnormal sphenoid bone morphology 0.0993407077003097 0.27610057028438 0.760874929401378 0.727272727272727 14.3 14 3 enlarged cranium 0.0993407077003097 0.27610057028438 0.760874929401378 0.727272727272727 14.3 14 3 abnormal sebaceous gland morphology 0.0993407077003097 0.27610057028438 0.760874929401378 0.727272727272727 14.3 14 3 abnormal hemoglobin 0.0993407077003097 0.27610057028438 0.760874929401378 0.727272727272727 14.3 14 3 vasculitis 0.0993407077003097 0.27610057028438 0.760874929401378 0.727272727272727 14.3 14 3 secondary sex reversal 0.0993407077003097 0.27610057028438 0.760874929401378 0.727272727272727 14.3 14 3 abnormal primary sex determination 0.0993407077003097 0.27610057028438 0.760874929401378 0.727272727272727 14.3 14 3 abnormal bronchiole morphology 0.0993407077003097 0.27610057028438 0.760874929401378 0.727272727272727 14.3 14 3 decreased post-tetanic potentiation 0.0993407077003097 0.27610057028438 0.760874929401378 0.727272727272727 14.3 14 3 allodynia 0.0993407077003097 0.27610057028438 0.760874929401378 0.727272727272727 14.3 14 3 fused joints 0.0993407077003097 0.27610057028438 0.760874929401378 0.727272727272727 14.3 14 3 rectal hemorrhage 0.0993407077003097 0.27610057028438 0.760874929401378 0.727272727272727 14.3 14 3 dilated renal glomerular capsule 0.0993407077003097 0.27610057028438 0.760874929401378 0.727272727272727 14.3 14 3 abnormal spinal cord ventral horn morphology 0.0993407077003097 0.27610057028438 0.760874929401378 0.727272727272727 14.3 14 3 cyclopia 0.0993407077003097 0.27610057028438 0.760874929401378 0.727272727272727 14.3 14 3 increased glycogen level 0.0993407077003097 0.27610057028438 0.760874929401378 0.727272727272727 14.3 14 3 abnormal palate development 0.0993407077003097 0.27610057028438 0.760874929401378 0.727272727272727 14.3 14 3 abnormal palatal shelf elevation 0.0993407077003097 0.27610057028438 0.760874929401378 0.727272727272727 14.3 14 3 increased number of Howell-Jolly bodies 0.0993407077003097 0.27610057028438 0.760874929401378 0.727272727272727 14.3 14 3 shortened PR interval 0.0993407077003097 0.27610057028438 0.760874929401378 0.727272727272727 14.3 14 3 abnormal pulmonary alveolar sac morphology 0.0993407077003097 0.27610057028438 0.760874929401378 0.727272727272727 14.3 14 3 increased subcutaneous adipose tissue amount 0.0993407077003097 0.27610057028438 0.760874929401378 0.727272727272727 14.3 14 3 thin hypoglossal nerve 0.0993407077003097 0.27610057028438 0.760874929401378 0.727272727272727 14.3 14 3 alopecia 2.07126136221981e-06 3.56557968063791e-05 0.759873778178482 0.726315789473684 14.3 14 3 impaired hematopoiesis 0.000503683489083899 0.00433365988436815 0.759010039868532 0.725490196078431 14.3 14 3 abnormal gluconeogenesis 0.000503683489083899 0.00433365988436815 0.759010039868532 0.725490196078431 14.3 14 3 perinatal lethality 0.00206255288429971 0.0141852423068311 0.758497195246999 0.725 14.3 14 3 increased bone mineral content 4.46095408112673e-07 9.13342843868804e-06 0.75825724042408 0.724770642201835 14.3 14 3 decreased spleen weight 5.73457641192253e-05 0.000674456682016893 0.75811813617891 0.72463768115942 14.3 14 3 decreased trophoblast giant cell number 0.00872276513518882 0.0464622661108826 0.757595296084993 0.724137931034483 14.3 14 3 abnormal embryonic erythropoiesis 0.00872276513518882 0.0464622661108826 0.757595296084993 0.724137931034483 14.3 14 3 decreased bone strength 0.00872276513518882 0.0464622661108826 0.757595296084993 0.724137931034483 14.3 14 3 increased leukocyte cell number 6.5618546096396e-09 1.93167021792645e-07 0.757595296084993 0.724137931034483 14.3 14 3 abnormal retinal pigmentation 6.71815611258882e-06 0.000101898861768687 0.757595296084993 0.724137931034483 14.3 14 3 decreased anxiety-related response 9.65622333928369e-08 2.32075899096311e-06 0.757008695004014 0.723577235772358 14.3 14 3 increased respiratory quotient 0.00092187598152645 0.00711863119745182 0.756827722330095 0.723404255319149 14.3 14 3 decreased monocyte cell number 0.000103924575315267 0.00113134521267714 0.75648526634714 0.723076923076923 14.3 14 3 postnatal lethality 6.70714333845958e-10 2.25459716951597e-08 0.756291345489322 0.72289156626506 14.3 14 3 abnormal neuromuscular synapse morphology 4.75391233870676e-05 0.000565806552274309 0.75559107572498 0.722222222222222 14.3 14 3 abnormal mandible morphology 0.00041553191670526 0.00374405712813621 0.75559107572498 0.722222222222222 14.3 14 3 impaired limb coordination 0.00041553191670526 0.00374405712813621 0.75559107572498 0.722222222222222 14.3 14 3 abnormal long bone epiphyseal plate proliferative zone 0.00041553191670526 0.00374405712813621 0.75559107572498 0.722222222222222 14.3 14 3 abnormal mitral valve morphology 0.0392249634653669 0.142858120966472 0.75559107572498 0.722222222222222 14.3 14 3 abnormal mammary gland morphology 0.0392249634653669 0.142858120966472 0.75559107572498 0.722222222222222 14.3 14 3 abnormal phrenic nerve morphology 0.0392249634653669 0.142858120966472 0.75559107572498 0.722222222222222 14.3 14 3 blepharoptosis 0.0392249634653669 0.142858120966472 0.75559107572498 0.722222222222222 14.3 14 3 abnormal Peyer's patch follicle morphology 0.0392249634653669 0.142858120966472 0.75559107572498 0.722222222222222 14.3 14 3 abnormal neutrophil morphology 0.0392249634653669 0.142858120966472 0.75559107572498 0.722222222222222 14.3 14 3 jerky movement 0.0392249634653669 0.142858120966472 0.75559107572498 0.722222222222222 14.3 14 3 decreased lactate dehydrogenase level 0.0392249634653669 0.142858120966472 0.75559107572498 0.722222222222222 14.3 14 3 abnormal pregnancy 0.0392249634653669 0.142858120966472 0.75559107572498 0.722222222222222 14.3 14 3 abnormal sperm axoneme morphology 0.0392249634653669 0.142858120966472 0.75559107572498 0.722222222222222 14.3 14 3 decreased tumor latency 0.0392249634653669 0.142858120966472 0.75559107572498 0.722222222222222 14.3 14 3 decreased total body fat amount 3.09706189451759e-18 3.34953976635327e-16 0.75489499919276 0.721556886227545 14.3 14 3 abnormal long bone morphology 0.000188513636589683 0.00188324365870215 0.754638249652187 0.721311475409836 14.3 14 3 abnormal male reproductive system morphology 0.00169106317706683 0.0118996312671959 0.754239392226366 0.720930232558139 14.3 14 3 increased circulating chloride level 0.000757881417493834 0.00620141455926287 0.753266180107365 0.72 14.3 14 3 abnormal thyroid gland morphology 0.0164088706722128 0.0732637664313417 0.753266180107365 0.72 14.3 14 3 spontaneous skin ulceration 0.0164088706722128 0.0732637664313417 0.753266180107365 0.72 14.3 14 3 increased pre-B cell number 0.0164088706722128 0.0732637664313417 0.753266180107365 0.72 14.3 14 3 abnormal vertebrae development 0.0164088706722128 0.0732637664313417 0.753266180107365 0.72 14.3 14 3 abnormal motor capabilities/coordination/movement 5.58243971106497e-08 1.40977855647453e-06 0.752949148886781 0.71969696969697 14.3 14 3 increased macrophage cell number 0.000342306502204557 0.00318909147653122 0.752532002543907 0.719298245614035 14.3 14 3 increased sacral vertebrae number 0.00015553856483677 0.00163595002127469 0.751958426322456 0.71875 14.3 14 3 abnormal auditory brainstem response waveform shape 0.00707643725146168 0.0394677974506971 0.751958426322456 0.71875 14.3 14 3 decreased startle reflex 3.82987079997967e-07 8.07356238555036e-06 0.751120122614181 0.717948717948718 14.3 14 3 abnormal excitatory postsynaptic currents 3.25469856573546e-05 0.00041306442256464 0.751120122614181 0.717948717948718 14.3 14 3 increased urine protein level 3.25469856573546e-05 0.00041306442256464 0.751120122614181 0.717948717948718 14.3 14 3 abnormal iris morphology 0.00311006833719882 0.0198366538173899 0.751120122614181 0.717948717948718 14.3 14 3 increased vascular permeability 0.00311006833719882 0.0198366538173899 0.751120122614181 0.717948717948718 14.3 14 3 abnormal neuron morphology 3.18783295904027e-06 5.2689265685134e-05 0.750307222048581 0.717171717171717 14.3 14 3 abnormal pancreatic islet morphology 0.000622271265440872 0.00521178374674804 0.750107831343812 0.716981132075472 14.3 14 3 abnormal long bone epiphyseal plate morphology 0.000281647947663157 0.00271550104578335 0.749778836680942 0.716666666666667 14.3 14 3 decreased white adipose tissue amount 0.000128187287826476 0.00137739040375101 0.749518587171507 0.716417910447761 14.3 14 3 increased circulating glucose level 3.20419526468178e-08 8.43432351417559e-07 0.749407842699408 0.716312056737589 14.3 14 3 increased granulocyte number 5.86022592769895e-05 0.000681182803511735 0.749307574055749 0.716216216216216 14.3 14 3 kidney cysts 5.86022592769895e-05 0.000681182803511735 0.749307574055749 0.716216216216216 14.3 14 3 increased exploration in new environment 2.68880739951051e-05 0.000349264146542161 0.749133032342715 0.716049382716049 14.3 14 3 impaired balance 2.63956989192944e-06 4.42150175499965e-05 0.748753147437876 0.715686274509804 14.3 14 3 abnormal circulating cholesterol level 0.0131982995828321 0.0646911728321082 0.74728787709064 0.714285714285714 14.3 14 3 myoclonus 0.0131982995828321 0.0646911728321082 0.74728787709064 0.714285714285714 14.3 14 3 abnormal respiration 0.0131982995828321 0.0646911728321082 0.74728787709064 0.714285714285714 14.3 14 3 hypoxia 0.0131982995828321 0.0646911728321082 0.74728787709064 0.714285714285714 14.3 14 3 increased triglyceride level 0.0131982995828321 0.0646911728321082 0.74728787709064 0.714285714285714 14.3 14 3 absent atrioventricular cushions 0.0767091299296115 0.232841928858949 0.74728787709064 0.714285714285714 14.3 14 3 abnormal zigzag hair morphology 0.0767091299296115 0.232841928858949 0.74728787709064 0.714285714285714 14.3 14 3 irregularly shaped pupil 0.0767091299296115 0.232841928858949 0.74728787709064 0.714285714285714 14.3 14 3 increased aggression towards males 0.0767091299296115 0.232841928858949 0.74728787709064 0.714285714285714 14.3 14 3 extended life span 0.0767091299296115 0.232841928858949 0.74728787709064 0.714285714285714 14.3 14 3 abnormal fluid regulation 0.0767091299296115 0.232841928858949 0.74728787709064 0.714285714285714 14.3 14 3 absent otoliths 0.0767091299296115 0.232841928858949 0.74728787709064 0.714285714285714 14.3 14 3 abnormal voluntary movement 0.0767091299296115 0.232841928858949 0.74728787709064 0.714285714285714 14.3 14 3 abnormal vascular endothelial cell migration 0.0767091299296115 0.232841928858949 0.74728787709064 0.714285714285714 14.3 14 3 abnormal imprinting 0.0767091299296115 0.232841928858949 0.74728787709064 0.714285714285714 14.3 14 3 abnormal sagittal suture morphology 0.0767091299296115 0.232841928858949 0.74728787709064 0.714285714285714 14.3 14 3 abnormal squamosal bone morphology 0.0767091299296115 0.232841928858949 0.74728787709064 0.714285714285714 14.3 14 3 increased stomach tumor incidence 0.0767091299296115 0.232841928858949 0.74728787709064 0.714285714285714 14.3 14 3 increased lung compliance 0.0767091299296115 0.232841928858949 0.74728787709064 0.714285714285714 14.3 14 3 cochlear degeneration 0.208436467750638 0.452628296403065 0.74728787709064 0.714285714285714 14.3 14 3 failure of atrioventricular cushion closure 0.208436467750638 0.452628296403065 0.74728787709064 0.714285714285714 14.3 14 3 cellular necrosis 0.208436467750638 0.452628296403065 0.74728787709064 0.714285714285714 14.3 14 3 absent hair follicles 0.208436467750638 0.452628296403065 0.74728787709064 0.714285714285714 14.3 14 3 abnormal oculomotor nerve morphology 0.208436467750638 0.452628296403065 0.74728787709064 0.714285714285714 14.3 14 3 abnormal lacrimal gland morphology 0.208436467750638 0.452628296403065 0.74728787709064 0.714285714285714 14.3 14 3 abnormal liquid preference 0.208436467750638 0.452628296403065 0.74728787709064 0.714285714285714 14.3 14 3 abnormal circulating free fatty acids level 0.208436467750638 0.452628296403065 0.74728787709064 0.714285714285714 14.3 14 3 abnormal vascular permeability 0.208436467750638 0.452628296403065 0.74728787709064 0.714285714285714 14.3 14 3 increased chemically-elicited antinociception 0.208436467750638 0.452628296403065 0.74728787709064 0.714285714285714 14.3 14 3 increased colonic adenoma incidence 0.208436467750638 0.452628296403065 0.74728787709064 0.714285714285714 14.3 14 3 abnormal lymph node primary follicle morphology 0.208436467750638 0.452628296403065 0.74728787709064 0.714285714285714 14.3 14 3 abnormal melanocyte morphology 0.208436467750638 0.452628296403065 0.74728787709064 0.714285714285714 14.3 14 3 increased retinal ganglion cell number 0.208436467750638 0.452628296403065 0.74728787709064 0.714285714285714 14.3 14 3 decreased urine calcium level 0.208436467750638 0.452628296403065 0.74728787709064 0.714285714285714 14.3 14 3 detached tectorial membrane 0.208436467750638 0.452628296403065 0.74728787709064 0.714285714285714 14.3 14 3 calcinosis 0.208436467750638 0.452628296403065 0.74728787709064 0.714285714285714 14.3 14 3 abnormal sinus venosus morphology 0.208436467750638 0.452628296403065 0.74728787709064 0.714285714285714 14.3 14 3 abnormal thyroid gland development 0.208436467750638 0.452628296403065 0.74728787709064 0.714285714285714 14.3 14 3 abnormal Purkinje cell innervation 0.208436467750638 0.452628296403065 0.74728787709064 0.714285714285714 14.3 14 3 increased ectoderm apoptosis 0.208436467750638 0.452628296403065 0.74728787709064 0.714285714285714 14.3 14 3 renal necrosis 0.208436467750638 0.452628296403065 0.74728787709064 0.714285714285714 14.3 14 3 utricular macular degeneration 0.208436467750638 0.452628296403065 0.74728787709064 0.714285714285714 14.3 14 3 abnormal strial marginal cell morphology 0.208436467750638 0.452628296403065 0.74728787709064 0.714285714285714 14.3 14 3 absent endocochlear potential 0.208436467750638 0.452628296403065 0.74728787709064 0.714285714285714 14.3 14 3 increased adrenocorticotropin level 0.208436467750638 0.452628296403065 0.74728787709064 0.714285714285714 14.3 14 3 absent thyroid gland 0.208436467750638 0.452628296403065 0.74728787709064 0.714285714285714 14.3 14 3 atherosclerotic lesions 0.208436467750638 0.452628296403065 0.74728787709064 0.714285714285714 14.3 14 3 abnormal renal/urinary system physiology 0.208436467750638 0.452628296403065 0.74728787709064 0.714285714285714 14.3 14 3 abnormal body temperature 0.208436467750638 0.452628296403065 0.74728787709064 0.714285714285714 14.3 14 3 retinal pigment epithelium atrophy 0.208436467750638 0.452628296403065 0.74728787709064 0.714285714285714 14.3 14 3 abnormal renal filtration rate 0.208436467750638 0.452628296403065 0.74728787709064 0.714285714285714 14.3 14 3 increased keratinocyte apoptosis 0.208436467750638 0.452628296403065 0.74728787709064 0.714285714285714 14.3 14 3 abnormal uterus physiology 0.208436467750638 0.452628296403065 0.74728787709064 0.714285714285714 14.3 14 3 abnormal spinal cord central canal morphology 0.208436467750638 0.452628296403065 0.74728787709064 0.714285714285714 14.3 14 3 heart hemorrhage 0.208436467750638 0.452628296403065 0.74728787709064 0.714285714285714 14.3 14 3 decreased DN4 thymocyte number 0.208436467750638 0.452628296403065 0.74728787709064 0.714285714285714 14.3 14 3 heart right ventricle outflow tract stenosis 0.208436467750638 0.452628296403065 0.74728787709064 0.714285714285714 14.3 14 3 thick pulmonary valve 0.208436467750638 0.452628296403065 0.74728787709064 0.714285714285714 14.3 14 3 thick mitral valve cusps 0.208436467750638 0.452628296403065 0.74728787709064 0.714285714285714 14.3 14 3 altered tumor pathology 0.208436467750638 0.452628296403065 0.74728787709064 0.714285714285714 14.3 14 3 increased right ventricle systolic pressure 0.208436467750638 0.452628296403065 0.74728787709064 0.714285714285714 14.3 14 3 dilated pulmonary alveolar ducts 0.208436467750638 0.452628296403065 0.74728787709064 0.714285714285714 14.3 14 3 abnormal tricarboxylic acid cycle 0.208436467750638 0.452628296403065 0.74728787709064 0.714285714285714 14.3 14 3 increased compact bone volume 0.208436467750638 0.452628296403065 0.74728787709064 0.714285714285714 14.3 14 3 small tail bud 0.208436467750638 0.452628296403065 0.74728787709064 0.714285714285714 14.3 14 3 decreased volumetric bone mineral density 0.208436467750638 0.452628296403065 0.74728787709064 0.714285714285714 14.3 14 3 decreased areal bone mineral density 0.208436467750638 0.452628296403065 0.74728787709064 0.714285714285714 14.3 14 3 ductus venosus stenosis 0.208436467750638 0.452628296403065 0.74728787709064 0.714285714285714 14.3 14 3 embryo tumor 0.208436467750638 0.452628296403065 0.74728787709064 0.714285714285714 14.3 14 3 abnormal kidney morphology 1.04851210239484e-09 3.365385618977e-08 0.74728787709064 0.714285714285714 14.3 14 3 abnormal nervous system electrophysiology 2.21936967011309e-05 0.000292099579598217 0.74728787709064 0.714285714285714 14.3 14 3 impaired fertilization 0.000105545398269377 0.00114648112748941 0.74728787709064 0.714285714285714 14.3 14 3 absent kidney 0.00113262177359936 0.00851177239223081 0.74728787709064 0.714285714285714 14.3 14 3 disheveled coat 0.0025345989111074 0.0167904521741136 0.74728787709064 0.714285714285714 14.3 14 3 abnormal muscle morphology 0.0025345989111074 0.0167904521741136 0.74728787709064 0.714285714285714 14.3 14 3 abnormal spleen white pulp morphology 0.0025345989111074 0.0167904521741136 0.74728787709064 0.714285714285714 14.3 14 3 abnormal stapes morphology 0.0311319617800792 0.118614999898618 0.74728787709064 0.714285714285714 14.3 14 3 abnormal T cell differentiation 3.90011567409456e-06 6.25905660600659e-05 0.745808099116203 0.712871287128713 14.3 14 3 abnormal posture 3.98052761231269e-05 0.000485370707628814 0.745419657397913 0.7125 14.3 14 3 abnormal retinal pigment epithelium morphology 3.98052761231269e-05 0.000485370707628814 0.745419657397913 0.7125 14.3 14 3 decreased percent body fat/body weight 8.68327212008434e-05 0.000970770310054373 0.745240513043816 0.712328767123288 14.3 14 3 abnormal hair growth 0.000925779775829412 0.00711863119745182 0.744413692947983 0.711538461538462 14.3 14 3 abnormal myocardial fiber morphology 6.96307972101497e-06 0.000105292770857293 0.744206277597482 0.711340206185567 14.3 14 3 reduced female fertility 4.32750611859548e-12 2.07012912884736e-10 0.744066808654904 0.711206896551724 14.3 14 3 cardiomyopathy 0.00206434481007955 0.0141852423068311 0.743966597636904 0.711111111111111 14.3 14 3 abnormal bone mineralization 5.7210342832747e-07 1.12945022060681e-05 0.743582317369529 0.710743801652893 14.3 14 3 increased bone marrow cell number 0.00464967887524149 0.0279036820317568 0.743354783000689 0.710526315789474 14.3 14 3 increased circulating cholesterol level 1.87622493473066e-09 5.90773357612976e-08 0.743041923243534 0.710227272727273 14.3 14 3 abnormal eyelid morphology 0.0106201929399875 0.0542458520291972 0.742466664980377 0.709677419354839 14.3 14 3 no abnormal phenotype detected 1.03873350198106e-81 1.72256639078526e-78 0.742291600794241 0.709510086455331 14.3 14 3 cochlear outer hair cell degeneration 0.00012801872607293 0.00137739040375101 0.741060478114884 0.708333333333333 14.3 14 3 oligodactyly 0.00168066518607074 0.0118432143069432 0.741060478114884 0.708333333333333 14.3 14 3 abnormal malleus morphology 0.024764764216042 0.104058025316561 0.741060478114884 0.708333333333333 14.3 14 3 abnormal adrenal gland morphology 0.024764764216042 0.104058025316561 0.741060478114884 0.708333333333333 14.3 14 3 curly vibrissae 0.024764764216042 0.104058025316561 0.741060478114884 0.708333333333333 14.3 14 3 increased stereotypic behavior 0.024764764216042 0.104058025316561 0.741060478114884 0.708333333333333 14.3 14 3 abnormal primitive streak formation 0.024764764216042 0.104058025316561 0.741060478114884 0.708333333333333 14.3 14 3 abnormal tumor morphology 0.024764764216042 0.104058025316561 0.741060478114884 0.708333333333333 14.3 14 3 decreased fatty acid level 0.024764764216042 0.104058025316561 0.741060478114884 0.708333333333333 14.3 14 3 decreased T cell number 1.25717060410015e-08 3.61527384705101e-07 0.740789721637678 0.708074534161491 14.3 14 3 short ulna 0.00376811974584036 0.0231151612029048 0.739997263655609 0.707317073170732 14.3 14 3 thrombocytosis 0.00061756779145406 0.00518111258428997 0.739557312844874 0.706896551724138 14.3 14 3 impaired synaptic plasticity 0.00855069798981492 0.0457908745956181 0.73849625500722 0.705882352941177 14.3 14 3 abnormal spleen red pulp morphology 0.00855069798981492 0.0457908745956181 0.73849625500722 0.705882352941177 14.3 14 3 abnormal adipose tissue morphology 0.0597376833090282 0.187741613684406 0.73849625500722 0.705882352941177 14.3 14 3 abnormal melanosome morphology 0.0597376833090282 0.187741613684406 0.73849625500722 0.705882352941177 14.3 14 3 decreased growth hormone level 0.0597376833090282 0.187741613684406 0.73849625500722 0.705882352941177 14.3 14 3 pancytopenia 0.0597376833090282 0.187741613684406 0.73849625500722 0.705882352941177 14.3 14 3 increased circulating magnesium level 0.0597376833090282 0.187741613684406 0.73849625500722 0.705882352941177 14.3 14 3 increased hepatoma incidence 0.0597376833090282 0.187741613684406 0.73849625500722 0.705882352941177 14.3 14 3 abnormal survival 0.0597376833090282 0.187741613684406 0.73849625500722 0.705882352941177 14.3 14 3 delayed heart development 0.0597376833090282 0.187741613684406 0.73849625500722 0.705882352941177 14.3 14 3 abnormal lung morphology 1.22641074028815e-06 2.17131438894432e-05 0.73849625500722 0.705882352941177 14.3 14 3 cardiac fibrosis 3.95427981232365e-05 0.000485370707628814 0.73849625500722 0.705882352941177 14.3 14 3 abnormal cornea morphology 8.6027514279616e-05 0.000963934422389842 0.737707263281785 0.705128205128205 14.3 14 3 insulin resistance 3.87051466626901e-07 8.12481454206258e-06 0.737097587857585 0.704545454545455 14.3 14 3 increased T cell number 3.24476202238496e-05 0.00041306442256464 0.737097587857585 0.704545454545455 14.3 14 3 abnormal astrocyte morphology 0.00305390083078563 0.0195284789629287 0.737097587857585 0.704545454545455 14.3 14 3 abnormal amino acid level 0.00305390083078563 0.0195284789629287 0.737097587857585 0.704545454545455 14.3 14 3 abnormal skeleton morphology 2.17258076240434e-06 3.71429185325141e-05 0.7368908283659 0.704347826086957 14.3 14 3 decreased liver weight 0.000187766963584293 0.00187955863950072 0.736762695723166 0.704225352112676 14.3 14 3 diluted coat color 0.00111327721868793 0.00841725556682745 0.736216945578186 0.703703703703704 14.3 14 3 decreased platelet aggregation 0.00111327721868793 0.00841725556682745 0.736216945578186 0.703703703703704 14.3 14 3 abnormal fetal cardiomyocyte proliferation 0.0197417224450352 0.0861535694421492 0.736216945578186 0.703703703703704 14.3 14 3 abnormal skin appearance 0.0197417224450352 0.0861535694421492 0.736216945578186 0.703703703703704 14.3 14 3 increased thermal nociceptive threshold 2.66167987152493e-05 0.000346645480650171 0.735791140520014 0.703296703296703 14.3 14 3 increased insulin secretion 0.00688909413895115 0.038639507712832 0.735169695299981 0.702702702702703 14.3 14 3 increased or absent threshold for auditory brainstem response 1.16332290309638e-13 7.14510054679568e-12 0.734876175325812 0.70242214532872 14.3 14 3 hepatic necrosis 0.00247545399931606 0.0166875117162566 0.734568083438033 0.702127659574468 14.3 14 3 abnormal femur morphology 0.000335742009395657 0.00313380205767991 0.733903616605434 0.701492537313433 14.3 14 3 increased circulating insulin level 4.62428683150936e-08 1.19893496018001e-06 0.732342119548827 0.7 14.3 14 3 liver inflammation 2.130390182984e-06 3.65472108977428e-05 0.732342119548827 0.7 14.3 14 3 decreased insulin secretion 3.87062499065661e-05 0.000480208462057772 0.732342119548827 0.7 14.3 14 3 decreased circulating alkaline phosphatase level 0.00200701593784559 0.013906551937022 0.732342119548827 0.7 14.3 14 3 decreased circulating phosphate level 0.00555427106063007 0.0320934942237335 0.732342119548827 0.7 14.3 14 3 increased susceptibility to weight loss 0.00555427106063007 0.0320934942237335 0.732342119548827 0.7 14.3 14 3 gastrointestinal hemorrhage 0.015768054911253 0.0730191653905403 0.732342119548827 0.7 14.3 14 3 abnormal spleen marginal zone morphology 0.015768054911253 0.0730191653905403 0.732342119548827 0.7 14.3 14 3 waved hair 0.0468193643685676 0.166053585824018 0.732342119548827 0.7 14.3 14 3 abnormal circulating enzyme level 0.0468193643685676 0.166053585824018 0.732342119548827 0.7 14.3 14 3 abnormal hair texture 0.0468193643685676 0.166053585824018 0.732342119548827 0.7 14.3 14 3 decreased myocardial infarction size 0.0468193643685676 0.166053585824018 0.732342119548827 0.7 14.3 14 3 kidney atrophy 0.0468193643685676 0.166053585824018 0.732342119548827 0.7 14.3 14 3 abnormal induced retinal neovascularization 0.0468193643685676 0.166053585824018 0.732342119548827 0.7 14.3 14 3 enhanced behavioral response to xenobiotic 0.0468193643685676 0.166053585824018 0.732342119548827 0.7 14.3 14 3 abnormal heart electrocardiography waveform feature 0.0468193643685676 0.166053585824018 0.732342119548827 0.7 14.3 14 3 abnormal lateral semicircular canal morphology 0.15394326046724 0.365569317816 0.732342119548827 0.7 14.3 14 3 absent maxillary shelf 0.15394326046724 0.365569317816 0.732342119548827 0.7 14.3 14 3 increased cranium width 0.15394326046724 0.365569317816 0.732342119548827 0.7 14.3 14 3 jaundice 0.15394326046724 0.365569317816 0.732342119548827 0.7 14.3 14 3 alcohol preference 0.15394326046724 0.365569317816 0.732342119548827 0.7 14.3 14 3 decreased incidence of induced tumors 0.15394326046724 0.365569317816 0.732342119548827 0.7 14.3 14 3 abnormal gland morphology 0.15394326046724 0.365569317816 0.732342119548827 0.7 14.3 14 3 impaired social transmission of food preference 0.15394326046724 0.365569317816 0.732342119548827 0.7 14.3 14 3 abnormal primordial germ cell migration 0.15394326046724 0.365569317816 0.732342119548827 0.7 14.3 14 3 absent seminal vesicle 0.15394326046724 0.365569317816 0.732342119548827 0.7 14.3 14 3 increased defecation amount 0.15394326046724 0.365569317816 0.732342119548827 0.7 14.3 14 3 abnormal gas homeostasis 0.15394326046724 0.365569317816 0.732342119548827 0.7 14.3 14 3 abnormal respiratory conducting tube morphology 0.15394326046724 0.365569317816 0.732342119548827 0.7 14.3 14 3 abnormal gonadal fat pad morphology 0.15394326046724 0.365569317816 0.732342119548827 0.7 14.3 14 3 abnormal developmental vascular remodeling 0.15394326046724 0.365569317816 0.732342119548827 0.7 14.3 14 3 abnormal hippocampus neuron morphology 0.15394326046724 0.365569317816 0.732342119548827 0.7 14.3 14 3 abnormal cerebellar granule cell migration 0.15394326046724 0.365569317816 0.732342119548827 0.7 14.3 14 3 umbilical hernia 0.15394326046724 0.365569317816 0.732342119548827 0.7 14.3 14 3 increased T-helper 17 cell number 0.15394326046724 0.365569317816 0.732342119548827 0.7 14.3 14 3 abnormal vibrissa follicle morphology 0.15394326046724 0.365569317816 0.732342119548827 0.7 14.3 14 3 increased kidney iron level 0.15394326046724 0.365569317816 0.732342119548827 0.7 14.3 14 3 common ventricle 0.15394326046724 0.365569317816 0.732342119548827 0.7 14.3 14 3 abnormal left subclavian artery morphology 0.15394326046724 0.365569317816 0.732342119548827 0.7 14.3 14 3 fusion of atlas and odontoid process 0.15394326046724 0.365569317816 0.732342119548827 0.7 14.3 14 3 abnormal pulmonary interalveolar septum morphology 0.15394326046724 0.365569317816 0.732342119548827 0.7 14.3 14 3 abnormal adaptive thermogenesis 0.15394326046724 0.365569317816 0.732342119548827 0.7 14.3 14 3 abnormal lipid homeostasis 8.15332679025078e-07 1.49678231666043e-05 0.732342119548827 0.7 14.3 14 3 increased spleen weight 4.57819104588806e-06 7.25366256474303e-05 0.731416276161281 0.699115044247788 14.3 14 3 abnormal lipid level 8.39007154439481e-05 0.000942225867570298 0.731081633973011 0.698795180722892 14.3 14 3 increased anxiety-related response 4.51630299796167e-07 9.13342843868804e-06 0.730084127402222 0.697841726618705 14.3 14 3 enlarged pericardium 0.0126162897650859 0.0627033382430595 0.729171807342988 0.696969696969697 14.3 14 3 abnormal skeleton physiology 0.0126162897650859 0.0627033382430595 0.729171807342988 0.696969696969697 14.3 14 3 single kidney 0.0126162897650859 0.0627033382430595 0.729171807342988 0.696969696969697 14.3 14 3 abnormal middle ear ossicle morphology 0.0126162897650859 0.0627033382430595 0.729171807342988 0.696969696969697 14.3 14 3 abnormal cochlear ganglion morphology 0.0368788675621264 0.137535506837765 0.727793410731753 0.695652173913043 14.3 14 3 abnormal vertebral artery topology 0.0368788675621264 0.137535506837765 0.727793410731753 0.695652173913043 14.3 14 3 syndactyly 0.00107138939221834 0.00817509543908936 0.727022443135639 0.694915254237288 14.3 14 3 increased B cell proliferation 0.00107138939221834 0.00817509543908936 0.727022443135639 0.694915254237288 14.3 14 3 impaired righting response 3.74238096131753e-05 0.000465458632063868 0.726835787822896 0.694736842105263 14.3 14 3 increased inflammatory response 3.74238096131753e-05 0.000465458632063868 0.726835787822896 0.694736842105263 14.3 14 3 impaired wound healing 0.0101104331328329 0.0519507805780809 0.726529880504789 0.694444444444444 14.3 14 3 increased total body fat amount 1.13933075889162e-06 2.03891026096613e-05 0.726096131322398 0.694029850746269 14.3 14 3 abnormal spatial learning 9.28601894447925e-08 2.24261865285361e-06 0.725281853716191 0.693251533742331 14.3 14 3 decreased cardiac muscle contractility 2.04185591806038e-05 0.000274546843036497 0.724294403949389 0.692307692307692 14.3 14 3 abnormal stomach morphology 0.0291664657407342 0.115069918366497 0.724294403949389 0.692307692307692 14.3 14 3 abnormal ureter morphology 0.0291664657407342 0.115069918366497 0.724294403949389 0.692307692307692 14.3 14 3 no spontaneous movement 0.0291664657407342 0.115069918366497 0.724294403949389 0.692307692307692 14.3 14 3 decreased circulating glycerol level 0.0291664657407342 0.115069918366497 0.724294403949389 0.692307692307692 14.3 14 3 absent common myeloid progenitor cells 0.116435173341015 0.293697373955128 0.724294403949389 0.692307692307692 14.3 14 3 absent myocardial trabeculae 0.116435173341015 0.293697373955128 0.724294403949389 0.692307692307692 14.3 14 3 abnormal mast cell morphology 0.116435173341015 0.293697373955128 0.724294403949389 0.692307692307692 14.3 14 3 abnormal sympathetic ganglion morphology 0.116435173341015 0.293697373955128 0.724294403949389 0.692307692307692 14.3 14 3 uterus hypoplasia 0.116435173341015 0.293697373955128 0.724294403949389 0.692307692307692 14.3 14 3 pup cannibalization 0.116435173341015 0.293697373955128 0.724294403949389 0.692307692307692 14.3 14 3 lymphoid hypoplasia 0.116435173341015 0.293697373955128 0.724294403949389 0.692307692307692 14.3 14 3 abnormal otolith morphology 0.116435173341015 0.293697373955128 0.724294403949389 0.692307692307692 14.3 14 3 anal atresia 0.116435173341015 0.293697373955128 0.724294403949389 0.692307692307692 14.3 14 3 abnormal GABAergic neuron morphology 0.116435173341015 0.293697373955128 0.724294403949389 0.692307692307692 14.3 14 3 abnormal retinal inner plexiform layer morphology 0.116435173341015 0.293697373955128 0.724294403949389 0.692307692307692 14.3 14 3 vestibular hair cell degeneration 0.116435173341015 0.293697373955128 0.724294403949389 0.692307692307692 14.3 14 3 decreased endocochlear potential 0.116435173341015 0.293697373955128 0.724294403949389 0.692307692307692 14.3 14 3 abnormal exocrine pancreas morphology 0.116435173341015 0.293697373955128 0.724294403949389 0.692307692307692 14.3 14 3 increased circulating ammonia level 0.116435173341015 0.293697373955128 0.724294403949389 0.692307692307692 14.3 14 3 small pituitary gland 0.116435173341015 0.293697373955128 0.724294403949389 0.692307692307692 14.3 14 3 orthokeratosis 0.116435173341015 0.293697373955128 0.724294403949389 0.692307692307692 14.3 14 3 abnormal glucose homeostasis 1.97800140291999e-08 5.46697609973718e-07 0.724294403949389 0.692307692307692 14.3 14 3 abnormal locomotor activation 6.59075150870299e-05 0.000762534622227846 0.724294403949389 0.692307692307692 14.3 14 3 increased body weight 5.19800671358968e-10 1.79583912500754e-08 0.723935130931557 0.691964285714286 14.3 14 3 increased T cell proliferation 1.66845067393525e-05 0.000229296743172041 0.723542280996171 0.691588785046729 14.3 14 3 increased sensitivity to xenobiotic induced morbidity/mortality 1.36334223169851e-05 0.000190523247266856 0.72283118293131 0.690909090909091 14.3 14 3 abnormal contextual conditioning behavior 0.00191125335034393 0.0133358841766634 0.72283118293131 0.690909090909091 14.3 14 3 abnormal cartilage morphology 0.00651982006947541 0.0372400744496443 0.722378281187618 0.69047619047619 14.3 14 3 corneal opacity 0.000465864236376489 0.00409335161130949 0.722027441808703 0.690140845070423 14.3 14 3 increased circulating free fatty acid level 0.000465864236376489 0.00409335161130949 0.722027441808703 0.690140845070423 14.3 14 3 abnormal skeletal muscle fiber morphology 0.000465864236376489 0.00409335161130949 0.722027441808703 0.690140845070423 14.3 14 3 decreased granulocyte number 0.0231439316887061 0.099430967315469 0.721519329604756 0.689655172413793 14.3 14 3 decreased retinal photoreceptor cell number 0.0231439316887061 0.099430967315469 0.721519329604756 0.689655172413793 14.3 14 3 abnormal outer ear morphology 0.0231439316887061 0.099430967315469 0.721519329604756 0.689655172413793 14.3 14 3 short sternum 0.0231439316887061 0.099430967315469 0.721519329604756 0.689655172413793 14.3 14 3 increased double-positive T cell number 0.0231439316887061 0.099430967315469 0.721519329604756 0.689655172413793 14.3 14 3 polychromatophilia 0.0231439316887061 0.099430967315469 0.721519329604756 0.689655172413793 14.3 14 3 increased circulating triglyceride level 7.33030393048046e-07 1.39191839901299e-05 0.721519329604755 0.689655172413793 14.3 14 3 increased blood urea nitrogen level 7.33030393048046e-07 1.39191839901299e-05 0.721519329604755 0.689655172413793 14.3 14 3 albuminuria 0.00524506059092055 0.0305552417328217 0.72071764146075 0.688888888888889 14.3 14 3 lethality at weaning, complete penetrance 0.00524506059092055 0.0305552417328217 0.72071764146075 0.688888888888889 14.3 14 3 abnormal renal glomerulus morphology 1.94688053445167e-05 0.000262485925715367 0.719864468757038 0.688073394495413 14.3 14 3 neonatal lethality 0.0184164554547445 0.0812250584107746 0.719264581699741 0.6875 14.3 14 3 failure of tooth eruption 0.0893706309503645 0.262466876610427 0.719264581699741 0.6875 14.3 14 3 abnormal mouth morphology 0.0893706309503645 0.262466876610427 0.719264581699741 0.6875 14.3 14 3 abnormal pituitary gland morphology 0.0893706309503645 0.262466876610427 0.719264581699741 0.6875 14.3 14 3 abnormal intestinal absorption 0.0893706309503645 0.262466876610427 0.719264581699741 0.6875 14.3 14 3 abnormal epicardium morphology 0.0893706309503645 0.262466876610427 0.719264581699741 0.6875 14.3 14 3 decreased cochlear coiling 0.0893706309503645 0.262466876610427 0.719264581699741 0.6875 14.3 14 3 large intestinal inflammation 0.0893706309503645 0.262466876610427 0.719264581699741 0.6875 14.3 14 3 bowed tibia 0.0893706309503645 0.262466876610427 0.719264581699741 0.6875 14.3 14 3 increased thymus weight 0.0893706309503645 0.262466876610427 0.719264581699741 0.6875 14.3 14 3 loose skin 0.0893706309503645 0.262466876610427 0.719264581699741 0.6875 14.3 14 3 kidney degeneration 0.0893706309503645 0.262466876610427 0.719264581699741 0.6875 14.3 14 3 increased heart left ventricle size 0.0893706309503645 0.262466876610427 0.719264581699741 0.6875 14.3 14 3 decreased fibroblast apoptosis 0.0893706309503645 0.262466876610427 0.719264581699741 0.6875 14.3 14 3 abnormal motor coordination/ balance 5.11077203149275e-05 0.000605383115635153 0.718604099990191 0.686868686868687 14.3 14 3 decreased compact bone thickness 0.000822522045012002 0.00657885397738699 0.718288646039361 0.686567164179104 14.3 14 3 maternal effect 0.000822522045012002 0.00657885397738699 0.718288646039361 0.686567164179104 14.3 14 3 abnormal cued conditioning behavior 0.00340495857696287 0.0210169589583006 0.717982470145909 0.686274509803922 14.3 14 3 abnormal response to novel object 0.00340495857696287 0.0210169589583006 0.717982470145909 0.686274509803922 14.3 14 3 increased oxygen consumption 0.000165512605539494 0.00172428849329374 0.7177439377638 0.686046511627907 14.3 14 3 thick pulmonary interalveolar septum 0.0146896445084103 0.0688144834551236 0.717396362007014 0.685714285714286 14.3 14 3 decreased circulating thyroxine level 0.0146896445084103 0.0688144834551236 0.717396362007014 0.685714285714286 14.3 14 3 decreased tumor growth/size 0.00274714564930023 0.0180066529713684 0.716842815431391 0.685185185185185 14.3 14 3 abnormal triglyceride level 0.0692934672390297 0.212536991069157 0.715823124371034 0.684210526315789 14.3 14 3 shiny skin 0.0692934672390297 0.212536991069157 0.715823124371034 0.684210526315789 14.3 14 3 thin dermal layer 0.0692934672390297 0.212536991069157 0.715823124371034 0.684210526315789 14.3 14 3 abnormal long term depression 0.0692934672390297 0.212536991069157 0.715823124371034 0.684210526315789 14.3 14 3 abnormal ear morphology 0.0692934672390297 0.212536991069157 0.715823124371034 0.684210526315789 14.3 14 3 abnormal neurotransmitter level 0.0692934672390297 0.212536991069157 0.715823124371034 0.684210526315789 14.3 14 3 abnormal metatarsal bone morphology 0.0692934672390297 0.212536991069157 0.715823124371034 0.684210526315789 14.3 14 3 increased circulating VLDL cholesterol level 0.0692934672390297 0.212536991069157 0.715823124371034 0.684210526315789 14.3 14 3 eyelids fail to open 0.0692934672390297 0.212536991069157 0.715823124371034 0.684210526315789 14.3 14 3 abnormal behavioral response to xenobiotic 0.0692934672390297 0.212536991069157 0.715823124371034 0.684210526315789 14.3 14 3 increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 0.0692934672390297 0.212536991069157 0.715823124371034 0.684210526315789 14.3 14 3 lung inflammation 3.14013713348291e-06 5.2073940796925e-05 0.715418247038245 0.683823529411765 14.3 14 3 decreased neutrophil cell number 1.50243907533699e-05 0.000207736765985848 0.715352497727792 0.683760683760684 14.3 14 3 arrested B cell differentiation 0.00940136620017707 0.0485184614583827 0.714480116633002 0.682926829268293 14.3 14 3 increased bone trabecula number 0.00940136620017707 0.0485184614583827 0.714480116633002 0.682926829268293 14.3 14 3 increased liver weight 0.000191161336447506 0.00190586703171612 0.713320246313792 0.681818181818182 14.3 14 3 impaired swimming 0.001172697763886 0.00879965516641457 0.713320246313792 0.681818181818182 14.3 14 3 osteoporosis 0.0075397605608824 0.0412201195498791 0.713320246313792 0.681818181818182 14.3 14 3 cochlear hair cell degeneration 0.0075397605608824 0.0412201195498791 0.713320246313792 0.681818181818182 14.3 14 3 decreased blood urea nitrogen level 0.0075397605608824 0.0412201195498791 0.713320246313792 0.681818181818182 14.3 14 3 abnormal basisphenoid bone morphology 0.0541265484430569 0.180724974212933 0.713320246313792 0.681818181818182 14.3 14 3 abnormal tail movements 0.0541265484430569 0.180724974212933 0.713320246313792 0.681818181818182 14.3 14 3 abnormal germ layer development 0.0541265484430569 0.180724974212933 0.713320246313792 0.681818181818182 14.3 14 3 increased myocardial infarction size 0.0541265484430569 0.180724974212933 0.713320246313792 0.681818181818182 14.3 14 3 increased coping response 0.0541265484430569 0.180724974212933 0.713320246313792 0.681818181818182 14.3 14 3 abnormal female reproductive system physiology 0.0541265484430569 0.180724974212933 0.713320246313792 0.681818181818182 14.3 14 3 abnormal limb posture 0.0541265484430569 0.180724974212933 0.713320246313792 0.681818181818182 14.3 14 3 abnormal basement membrane morphology 0.0541265484430569 0.180724974212933 0.713320246313792 0.681818181818182 14.3 14 3 abnormal mesenteric lymph node morphology 0.0541265484430569 0.180724974212933 0.713320246313792 0.681818181818182 14.3 14 3 pulmonary vascular congestion 0.0541265484430569 0.180724974212933 0.713320246313792 0.681818181818182 14.3 14 3 abnormal tibia morphology 0.00605526504529936 0.0347461863902703 0.712308444545971 0.680851063829787 14.3 14 3 abnormal heart left ventricle morphology 0.000769037513386666 0.00624761850146006 0.711999282894693 0.680555555555556 14.3 14 3 abnormal axon extension 0.0048691440102215 0.0287102468523857 0.711418058990289 0.68 14.3 14 3 abnormal energy expenditure 0.042521037996679 0.154185250753264 0.711418058990289 0.68 14.3 14 3 abnormal heart ventricle morphology 0.000505343815251215 0.0043346301394393 0.710881544616993 0.67948717948718 14.3 14 3 abnormal coat/ hair morphology 0.00391977082827151 0.0238688615307843 0.710628471799401 0.679245283018868 14.3 14 3 reduced long term potentiation 3.67140296974538e-05 0.000460081354520989 0.709923483236108 0.678571428571429 14.3 14 3 abnormal jaw morphology 0.0335556151541308 0.125612630091648 0.709923483236108 0.678571428571429 14.3 14 3 reddish skin 0.0335556151541308 0.125612630091648 0.709923483236108 0.678571428571429 14.3 14 3 enhanced coordination 0.0335556151541308 0.125612630091648 0.709923483236108 0.678571428571429 14.3 14 3 abnormal hormone level 0.0335556151541308 0.125612630091648 0.709923483236108 0.678571428571429 14.3 14 3 increased bone resorption 0.0335556151541308 0.125612630091648 0.709923483236108 0.678571428571429 14.3 14 3 corneal vascularization 0.0335556151541308 0.125612630091648 0.709923483236108 0.678571428571429 14.3 14 3 abnormal capillary morphology 0.0265785650509102 0.110394345353221 0.708718180208542 0.67741935483871 14.3 14 3 decreased thymus weight 0.0265785650509102 0.110394345353221 0.708718180208542 0.67741935483871 14.3 14 3 abnormal intestine physiology 0.0265785650509102 0.110394345353221 0.708718180208542 0.67741935483871 14.3 14 3 short maxilla 0.0211170725679254 0.0915134460151818 0.707725577715253 0.676470588235294 14.3 14 3 abnormal vision 0.0211170725679254 0.0915134460151818 0.707725577715253 0.676470588235294 14.3 14 3 increased width of hypertrophic chondrocyte zone 0.0211170725679254 0.0915134460151818 0.707725577715253 0.676470588235294 14.3 14 3 increased susceptibility to weight gain 0.0211170725679254 0.0915134460151818 0.707725577715253 0.676470588235294 14.3 14 3 decreased litter size 1.41955687572572e-10 5.30999658401164e-09 0.707397065146299 0.676156583629893 14.3 14 3 skin inflammation 0.0168215560367531 0.0743886589180861 0.706893937788443 0.675675675675676 14.3 14 3 abnormal muscle physiology 0.00030804428646158 0.00288610230724361 0.705305412085548 0.674157303370786 14.3 14 3 abnormal inner ear morphology 0.0086077622470702 0.0459974405791345 0.705049866646386 0.673913043478261 14.3 14 3 abnormal sleep pattern 0.0086077622470702 0.0459974405791345 0.705049866646386 0.673913043478261 14.3 14 3 abnormal long bone hypertrophic chondrocyte zone 0.00690749260257115 0.0386990717317471 0.70458571268546 0.673469387755102 14.3 14 3 absent corpus luteum 0.00555046809722358 0.0320934942237335 0.704175114950795 0.673076923076923 14.3 14 3 abnormal osteoclast physiology 0.00233922161370542 0.0159638237698004 0.702917659388383 0.671875 14.3 14 3 abnormal action potential 0.00152650659718254 0.0112011361666418 0.702450604465201 0.671428571428571 14.3 14 3 abnormal excitatory postsynaptic potential 0.000655143729596974 0.00547788244494949 0.701721543121698 0.670731707317073 14.3 14 3 abnormal cardiovascular system physiology 1.93041010723054e-05 0.000261950083778681 0.700090748011231 0.669172932330827 14.3 14 3 increased neutrophil cell number 8.50870960717486e-06 0.000125984613975283 0.699873749716613 0.668965517241379 14.3 14 3 abnormal cartilage development 0.012129160500806 0.0605241459292978 0.697468685284597 0.666666666666667 14.3 14 3 abnormal metabolism 0.012129160500806 0.0605241459292978 0.697468685284597 0.666666666666667 14.3 14 3 heart right ventricle hypertrophy 0.023848067259565 0.100973731588371 0.697468685284597 0.666666666666667 14.3 14 3 narrow eye opening 0.023848067259565 0.100973731588371 0.697468685284597 0.666666666666667 14.3 14 3 abnormal retinal blood vessel morphology 0.023848067259565 0.100973731588371 0.697468685284597 0.666666666666667 14.3 14 3 increased metastatic potential 0.0378956852436127 0.140694801557443 0.697468685284597 0.666666666666667 14.3 14 3 delayed eyelid opening 0.0378956852436127 0.140694801557443 0.697468685284597 0.666666666666667 14.3 14 3 abnormal pain threshold 0.0378956852436127 0.140694801557443 0.697468685284597 0.666666666666667 14.3 14 3 enhanced paired-pulse facilitation 0.0378956852436127 0.140694801557443 0.697468685284597 0.666666666666667 14.3 14 3 abnormal fat pad morphology 0.0378956852436127 0.140694801557443 0.697468685284597 0.666666666666667 14.3 14 3 abnormal white adipose tissue morphology 0.100763122996351 0.279273836716906 0.697468685284597 0.666666666666667 14.3 14 3 increased circulating glycerol level 0.100763122996351 0.279273836716906 0.697468685284597 0.666666666666667 14.3 14 3 absent ureter 0.100763122996351 0.279273836716906 0.697468685284597 0.666666666666667 14.3 14 3 abnormal glycogen homeostasis 0.100763122996351 0.279273836716906 0.697468685284597 0.666666666666667 14.3 14 3 abnormal aerobic respiration 0.100763122996351 0.279273836716906 0.697468685284597 0.666666666666667 14.3 14 3 vagina atresia 0.131062698496863 0.318066792693606 0.697468685284597 0.666666666666667 14.3 14 3 no suckling reflex 0.131062698496863 0.318066792693606 0.697468685284597 0.666666666666667 14.3 14 3 abnormal pericyte morphology 0.131062698496863 0.318066792693606 0.697468685284597 0.666666666666667 14.3 14 3 abnormal zygomatic bone morphology 0.131062698496863 0.318066792693606 0.697468685284597 0.666666666666667 14.3 14 3 abnormal secondary palate development 0.131062698496863 0.318066792693606 0.697468685284597 0.666666666666667 14.3 14 3 ostium primum atrial septal defect 0.131062698496863 0.318066792693606 0.697468685284597 0.666666666666667 14.3 14 3 decreased trabecular bone mass 0.131062698496863 0.318066792693606 0.697468685284597 0.666666666666667 14.3 14 3 distorted hair follicle pattern 0.232158048506604 0.454023698747277 0.697468685284597 0.666666666666667 14.3 14 3 abnormal urinary bladder urothelium morphology 0.232158048506604 0.454023698747277 0.697468685284597 0.666666666666667 14.3 14 3 absent parathyroid glands 0.232158048506604 0.454023698747277 0.697468685284597 0.666666666666667 14.3 14 3 abnormal cholinergic neuron morphology 0.232158048506604 0.454023698747277 0.697468685284597 0.666666666666667 14.3 14 3 abnormal vagina epithelium morphology 0.232158048506604 0.454023698747277 0.697468685284597 0.666666666666667 14.3 14 3 decreased level of surface class I molecules 0.232158048506604 0.454023698747277 0.697468685284597 0.666666666666667 14.3 14 3 abnormal lung volume 0.232158048506604 0.454023698747277 0.697468685284597 0.666666666666667 14.3 14 3 abnormal taste sensitivity 0.232158048506604 0.454023698747277 0.697468685284597 0.666666666666667 14.3 14 3 abnormal gut-associated lymphoid tissue morphology 0.232158048506604 0.454023698747277 0.697468685284597 0.666666666666667 14.3 14 3 abnormal posterior semicircular canal morphology 0.232158048506604 0.454023698747277 0.697468685284597 0.666666666666667 14.3 14 3 polycythemia 0.232158048506604 0.454023698747277 0.697468685284597 0.666666666666667 14.3 14 3 abnormal postural reflex 0.232158048506604 0.454023698747277 0.697468685284597 0.666666666666667 14.3 14 3 enlarged otoliths 0.232158048506604 0.454023698747277 0.697468685284597 0.666666666666667 14.3 14 3 biliary cyst 0.232158048506604 0.454023698747277 0.697468685284597 0.666666666666667 14.3 14 3 decreased muscle weight 0.232158048506604 0.454023698747277 0.697468685284597 0.666666666666667 14.3 14 3 decreased vestibular hair cell number 0.232158048506604 0.454023698747277 0.697468685284597 0.666666666666667 14.3 14 3 abnormal hair cell mechanoelectric transduction 0.232158048506604 0.454023698747277 0.697468685284597 0.666666666666667 14.3 14 3 abnormal gallbladder physiology 0.232158048506604 0.454023698747277 0.697468685284597 0.666666666666667 14.3 14 3 liver hyperplasia 0.232158048506604 0.454023698747277 0.697468685284597 0.666666666666667 14.3 14 3 abnormal intervertebral disk development 0.232158048506604 0.454023698747277 0.697468685284597 0.666666666666667 14.3 14 3 decreased pulmonary ventilation 0.232158048506604 0.454023698747277 0.697468685284597 0.666666666666667 14.3 14 3 increased tidal volume 0.232158048506604 0.454023698747277 0.697468685284597 0.666666666666667 14.3 14 3 eye opacity 0.232158048506604 0.454023698747277 0.697468685284597 0.666666666666667 14.3 14 3 abnormal cerebellar layer morphology 0.232158048506604 0.454023698747277 0.697468685284597 0.666666666666667 14.3 14 3 retropulsion 0.232158048506604 0.454023698747277 0.697468685284597 0.666666666666667 14.3 14 3 abnormal ventricle myocardium morphology 0.232158048506604 0.454023698747277 0.697468685284597 0.666666666666667 14.3 14 3 prolonged RR interval 0.232158048506604 0.454023698747277 0.697468685284597 0.666666666666667 14.3 14 3 iris coloboma 0.232158048506604 0.454023698747277 0.697468685284597 0.666666666666667 14.3 14 3 fusion of atlas and occipital bones 0.232158048506604 0.454023698747277 0.697468685284597 0.666666666666667 14.3 14 3 abnormal pulmonary alveolar system morphology 0.232158048506604 0.454023698747277 0.697468685284597 0.666666666666667 14.3 14 3 increased myeloid cell number 0.232158048506604 0.454023698747277 0.697468685284597 0.666666666666667 14.3 14 3 enhanced leukocyte tethering or rolling 0.232158048506604 0.454023698747277 0.697468685284597 0.666666666666667 14.3 14 3 increased B cell number 7.47756730705898e-05 0.000847400850856912 0.697468685284597 0.666666666666667 14.3 14 3 abnormal epidermal layer morphology 0.00213115459868447 0.0145838983885217 0.697468685284597 0.666666666666667 14.3 14 3 increased lymphocyte cell number 0.00213115459868447 0.0145838983885217 0.697468685284597 0.666666666666667 14.3 14 3 abnormal food intake 0.00213115459868447 0.0145838983885217 0.697468685284597 0.666666666666667 14.3 14 3 abnormal circulating amino acid level 0.00503973625720358 0.0295668489146083 0.697468685284597 0.666666666666667 14.3 14 3 increased kidney weight 0.00779751487673872 0.0424427095314826 0.697468685284597 0.666666666666667 14.3 14 3 abnormal thrombosis 0.00779751487673872 0.0424427095314826 0.697468685284597 0.666666666666667 14.3 14 3 abnormal intestinal epithelium morphology 0.00971781635898659 0.0500996231978842 0.697468685284597 0.666666666666667 14.3 14 3 abnormal T cell subpopulation ratio 0.0300167868340616 0.116529776262156 0.697468685284597 0.666666666666667 14.3 14 3 rectal prolapse 0.0480159523321322 0.16834345514613 0.697468685284597 0.666666666666667 14.3 14 3 abnormal type II pneumocyte morphology 0.0480159523321322 0.16834345514613 0.697468685284597 0.666666666666667 14.3 14 3 cryptorchism 0.0480159523321322 0.16834345514613 0.697468685284597 0.666666666666667 14.3 14 3 decreased susceptibility to pharmacologically induced seizures 0.0480159523321322 0.16834345514613 0.697468685284597 0.666666666666667 14.3 14 3 abnormal palate morphology 0.0480159523321322 0.16834345514613 0.697468685284597 0.666666666666667 14.3 14 3 abnormal bone trabecula morphology 0.0480159523321322 0.16834345514613 0.697468685284597 0.666666666666667 14.3 14 3 abnormal body weight 0.0611070742542956 0.191682026743455 0.697468685284597 0.666666666666667 14.3 14 3 abnormal retinal ganglion layer morphology 0.0611070742542956 0.191682026743455 0.697468685284597 0.666666666666667 14.3 14 3 small ears 0.0781941695455442 0.23522621969307 0.697468685284597 0.666666666666667 14.3 14 3 liver degeneration 0.0781941695455442 0.23522621969307 0.697468685284597 0.666666666666667 14.3 14 3 abnormal tumor vascularization 0.0781941695455442 0.23522621969307 0.697468685284597 0.666666666666667 14.3 14 3 abnormal enteric nervous system morphology 0.172716762229468 0.3915254240745 0.697468685284597 0.666666666666667 14.3 14 3 abnormal pilomotor reflex 0.172716762229468 0.3915254240745 0.697468685284597 0.666666666666667 14.3 14 3 small thyroid gland 0.172716762229468 0.3915254240745 0.697468685284597 0.666666666666667 14.3 14 3 abnormal aorta elastic fiber morphology 0.172716762229468 0.3915254240745 0.697468685284597 0.666666666666667 14.3 14 3 abnormal alisphenoid bone morphology 0.172716762229468 0.3915254240745 0.697468685284597 0.666666666666667 14.3 14 3 dilated bile duct 0.172716762229468 0.3915254240745 0.697468685284597 0.666666666666667 14.3 14 3 impaired sperm capacitation 0.172716762229468 0.3915254240745 0.697468685284597 0.666666666666667 14.3 14 3 vestibular saccular macula degeneration 0.172716762229468 0.3915254240745 0.697468685284597 0.666666666666667 14.3 14 3 abnormal cochlear outer hair cell physiology 0.172716762229468 0.3915254240745 0.697468685284597 0.666666666666667 14.3 14 3 hematuria 0.172716762229468 0.3915254240745 0.697468685284597 0.666666666666667 14.3 14 3 abnormal fatty acid level 0.172716762229468 0.3915254240745 0.697468685284597 0.666666666666667 14.3 14 3 abnormal patella morphology 0.172716762229468 0.3915254240745 0.697468685284597 0.666666666666667 14.3 14 3 abnormal somatic nervous system physiology 0.172716762229468 0.3915254240745 0.697468685284597 0.666666666666667 14.3 14 3 abnormal behavioral response to addictive substance 0.172716762229468 0.3915254240745 0.697468685284597 0.666666666666667 14.3 14 3 impaired behavioral response to cocaine 0.172716762229468 0.3915254240745 0.697468685284597 0.666666666666667 14.3 14 3 improved glucose tolerance 5.69034700278351e-07 1.12786758322103e-05 0.693910171584165 0.663265306122449 14.3 14 3 obese 0.00156070968057923 0.0113218362104329 0.692939667847684 0.662337662337662 14.3 14 3 increased eosinophil cell number 0.00454387559907849 0.0273016680017095 0.691843937822624 0.661290322580645 14.3 14 3 abnormal seminal vesicle morphology 0.00700991076247852 0.0391406352899334 0.691241286308842 0.660714285714286 14.3 14 3 abnormal circulating protein level 0.010864286928897 0.0552656722610045 0.690493998431751 0.66 14.3 14 3 short femur 0.000924030700618659 0.00711863119745182 0.689542904769999 0.659090909090909 14.3 14 3 renal interstitial fibrosis 0.0169348584439405 0.0747568063519113 0.689542904769999 0.659090909090909 14.3 14 3 liver fibrosis 0.0211987837384279 0.0916281052117106 0.688962969610395 0.658536585365854 14.3 14 3 increased tumor growth/size 0.0211987837384279 0.0916281052117106 0.688962969610395 0.658536585365854 14.3 14 3 short humerus 0.0211987837384279 0.0916281052117106 0.688962969610395 0.658536585365854 14.3 14 3 dehydration 0.00329006326822982 0.0204345377770828 0.687504846923388 0.657142857142857 14.3 14 3 abnormal intestinal goblet cell morphology 0.0334363096819959 0.125612630091648 0.687504846923388 0.657142857142857 14.3 14 3 decreased triglyceride level 0.0334363096819959 0.125612630091648 0.687504846923388 0.657142857142857 14.3 14 3 decreased glycogen level 0.0334363096819959 0.125612630091648 0.687504846923388 0.657142857142857 14.3 14 3 deafness 0.00054790112976308 0.00462785759010412 0.6869009779318 0.656565656565657 14.3 14 3 abnormal crypts of Lieberkuhn morphology 0.0421607742799538 0.152990409950963 0.686570737077025 0.65625 14.3 14 3 increased circulating follicle stimulating hormone level 0.0421607742799538 0.152990409950963 0.686570737077025 0.65625 14.3 14 3 abnormal lymphatic vessel morphology 0.0421607742799538 0.152990409950963 0.686570737077025 0.65625 14.3 14 3 decreased susceptibility to parasitic infection 0.0421607742799538 0.152990409950963 0.686570737077025 0.65625 14.3 14 3 glomerulosclerosis 0.00778232597577433 0.0424427095314826 0.685443363124518 0.655172413793103 14.3 14 3 abnormal enzyme/coenzyme level 0.00778232597577433 0.0424427095314826 0.685443363124518 0.655172413793103 14.3 14 3 abnormal middle ear morphology 0.0533378137384376 0.180724974212933 0.685443363124518 0.655172413793103 14.3 14 3 abnormal skin condition 0.0120419365713784 0.0604443955874404 0.684055825952201 0.653846153846154 14.3 14 3 abnormal leukocyte migration 0.0120419365713784 0.0604443955874404 0.684055825952201 0.653846153846154 14.3 14 3 abnormal brain wave pattern 0.0120419365713784 0.0604443955874404 0.684055825952201 0.653846153846154 14.3 14 3 decreased body temperature 0.0120419365713784 0.0604443955874404 0.684055825952201 0.653846153846154 14.3 14 3 abnormal Schwann cell morphology 0.0677463411467967 0.209210457607271 0.684055825952201 0.653846153846154 14.3 14 3 decreased bone resorption 0.0677463411467967 0.209210457607271 0.684055825952201 0.653846153846154 14.3 14 3 abnormal lymphocyte physiology 0.0187317822265606 0.0825426187574305 0.682306322561019 0.652173913043478 14.3 14 3 blistering 0.0864659500948009 0.256052441500973 0.682306322561019 0.652173913043478 14.3 14 3 abnormal chondrocyte physiology 0.0864659500948009 0.256052441500973 0.682306322561019 0.652173913043478 14.3 14 3 weight loss 9.91620640042079e-06 0.000143410252447946 0.681526543906663 0.651428571428571 14.3 14 3 abnormal organ of Corti morphology 0.0234185292233614 0.100032470964469 0.681248483301234 0.651162790697674 14.3 14 3 abnormal intestinal mucosa morphology 0.0234185292233614 0.100032470964469 0.681248483301234 0.651162790697674 14.3 14 3 impaired macrophage phagocytosis 0.0234185292233614 0.100032470964469 0.681248483301234 0.651162790697674 14.3 14 3 abnormal fibula morphology 0.111031086855602 0.293697373955128 0.680031968152482 0.65 14.3 14 3 decreased paired-pulse facilitation 0.111031086855602 0.293697373955128 0.680031968152482 0.65 14.3 14 3 abnormal lens epithelium morphology 0.111031086855602 0.293697373955128 0.680031968152482 0.65 14.3 14 3 increased brown adipose tissue amount 0.0368200879786022 0.137522475745905 0.678618180276905 0.648648648648649 14.3 14 3 decreased osteoblast cell number 0.0463329296553115 0.166053585824018 0.676954900423285 0.647058823529412 14.3 14 3 increased aggression towards mice 0.143697701626148 0.346532266403339 0.676954900423285 0.647058823529412 14.3 14 3 aminoaciduria 0.143697701626148 0.346532266403339 0.676954900423285 0.647058823529412 14.3 14 3 decreased body fat mass 0.143697701626148 0.346532266403339 0.676954900423285 0.647058823529412 14.3 14 3 abnormal cell cytoskeleton morphology 0.143697701626148 0.346532266403339 0.676954900423285 0.647058823529412 14.3 14 3 pale kidney 0.0584722674121623 0.184698114524132 0.674969695436707 0.645161290322581 14.3 14 3 decreased neuronal precursor cell number 0.0584722674121623 0.184698114524132 0.674969695436707 0.645161290322581 14.3 14 3 abnormal dendritic cell physiology 0.000802278286680791 0.00644803631056048 0.67465428903697 0.644859813084112 14.3 14 3 enhanced long term potentiation 0.0144718499372114 0.0679221258845534 0.672559089381576 0.642857142857143 14.3 14 3 abnormal ovulation 0.0740445592525344 0.226690266019298 0.672559089381576 0.642857142857143 14.3 14 3 abnormal blood flow velocity 0.187942051481542 0.419852584697202 0.672559089381576 0.642857142857143 14.3 14 3 translucent skin 0.187942051481542 0.419852584697202 0.672559089381576 0.642857142857143 14.3 14 3 abnormal placing response 0.187942051481542 0.419852584697202 0.672559089381576 0.642857142857143 14.3 14 3 abnormal adrenal gland secretion 0.187942051481542 0.419852584697202 0.672559089381576 0.642857142857143 14.3 14 3 decreased vascular permeability 0.187942051481542 0.419852584697202 0.672559089381576 0.642857142857143 14.3 14 3 intestinal obstruction 0.187942051481542 0.419852584697202 0.672559089381576 0.642857142857143 14.3 14 3 decreased CNS synapse formation 0.187942051481542 0.419852584697202 0.672559089381576 0.642857142857143 14.3 14 3 premature hair loss 0.187942051481542 0.419852584697202 0.672559089381576 0.642857142857143 14.3 14 3 increased circulating growth hormone level 0.187942051481542 0.419852584697202 0.672559089381576 0.642857142857143 14.3 14 3 abnormal glucose tolerance 0.187942051481542 0.419852584697202 0.672559089381576 0.642857142857143 14.3 14 3 decreased cornea thickness 0.187942051481542 0.419852584697202 0.672559089381576 0.642857142857143 14.3 14 3 pulmonary alveolar hemorrhage 0.187942051481542 0.419852584697202 0.672559089381576 0.642857142857143 14.3 14 3 abnormal renal tubule epithelial cell primary cilium morphology 0.187942051481542 0.419852584697202 0.672559089381576 0.642857142857143 14.3 14 3 decreased response to antigen 0.187942051481542 0.419852584697202 0.672559089381576 0.642857142857143 14.3 14 3 abnormal vibrissa morphology 0.0320605692367536 0.120834342388522 0.672559089381576 0.642857142857143 14.3 14 3 abnormal cytotoxic T cell physiology 0.0320605692367536 0.120834342388522 0.672559089381576 0.642857142857143 14.3 14 3 decreased eosinophil cell number 0.0102382943455192 0.0523489356309948 0.670223814765667 0.640625 14.3 14 3 decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 0.0941489164900581 0.275686203377304 0.669569937873213 0.64 14.3 14 3 increased liver glycogen level 0.0941489164900581 0.275686203377304 0.669569937873213 0.64 14.3 14 3 decreased IgM level 0.0019907630356483 0.0138131744802654 0.668707090015129 0.639175257731959 14.3 14 3 abnormal uterus morphology 0.0504001231986044 0.174610454674831 0.668407490064405 0.638888888888889 14.3 14 3 head tilt 0.0504001231986044 0.174610454674831 0.668407490064405 0.638888888888889 14.3 14 3 abnormal T-helper 1 physiology 0.027870411610783 0.110394345353221 0.667789166761848 0.638297872340426 14.3 14 3 dermatitis 0.0157156422636241 0.0730191653905403 0.667405379884399 0.637931034482759 14.3 14 3 abnormal coat appearance 0.0089785404477055 0.0468453249603532 0.667143959837441 0.63768115942029 14.3 14 3 abnormal cytokine secretion 0.000153477350932043 0.00162072047754594 0.665765563226206 0.636363636363636 14.3 14 3 abnormal CNS synaptic transmission 0.00215567534496168 0.0147314352214071 0.665765563226206 0.636363636363636 14.3 14 3 hyperglycemia 0.00369763036561923 0.0227107544061181 0.665765563226206 0.636363636363636 14.3 14 3 abnormal learning/memory/conditioning 0.0194952631116909 0.0858020515096926 0.665765563226206 0.636363636363636 14.3 14 3 hypertension 0.0347649530873478 0.130041835796658 0.665765563226206 0.636363636363636 14.3 14 3 absent vibrissae 0.0634127523102649 0.196193061407691 0.665765563226206 0.636363636363636 14.3 14 3 dilated heart atrium 0.0634127523102649 0.196193061407691 0.665765563226206 0.636363636363636 14.3 14 3 head tossing 0.0634127523102649 0.196193061407691 0.665765563226206 0.636363636363636 14.3 14 3 increased activated T cell number 0.120312506474897 0.301538901618444 0.665765563226206 0.636363636363636 14.3 14 3 intracerebral hemorrhage 0.120312506474897 0.301538901618444 0.665765563226206 0.636363636363636 14.3 14 3 abnormal cochlear sensory epithelium morphology 0.120312506474897 0.301538901618444 0.665765563226206 0.636363636363636 14.3 14 3 decreased cardiac output 0.120312506474897 0.301538901618444 0.665765563226206 0.636363636363636 14.3 14 3 failure of palatal shelf elevation 0.120312506474897 0.301538901618444 0.665765563226206 0.636363636363636 14.3 14 3 increased circulating creatine kinase level 0.120312506474897 0.301538901618444 0.665765563226206 0.636363636363636 14.3 14 3 abnormal stomach epithelium morphology 0.249497727809368 0.471420887144553 0.665765563226206 0.636363636363636 14.3 14 3 abnormal enteric ganglia morphology 0.249497727809368 0.471420887144553 0.665765563226206 0.636363636363636 14.3 14 3 abnormal hypothalamus secretion 0.249497727809368 0.471420887144553 0.665765563226206 0.636363636363636 14.3 14 3 abnormal larynx morphology 0.249497727809368 0.471420887144553 0.665765563226206 0.636363636363636 14.3 14 3 pulmonary hypertension 0.249497727809368 0.471420887144553 0.665765563226206 0.636363636363636 14.3 14 3 abnormal ureter development 0.249497727809368 0.471420887144553 0.665765563226206 0.636363636363636 14.3 14 3 pathological neovascularization 0.249497727809368 0.471420887144553 0.665765563226206 0.636363636363636 14.3 14 3 abnormal Bruch membrane morphology 0.249497727809368 0.471420887144553 0.665765563226206 0.636363636363636 14.3 14 3 abnormal platelet aggregation 0.249497727809368 0.471420887144553 0.665765563226206 0.636363636363636 14.3 14 3 abnormal superovulation 0.249497727809368 0.471420887144553 0.665765563226206 0.636363636363636 14.3 14 3 enhanced behavioral response to addictive substance 0.249497727809368 0.471420887144553 0.665765563226206 0.636363636363636 14.3 14 3 abnormal aorta smooth muscle morphology 0.249497727809368 0.471420887144553 0.665765563226206 0.636363636363636 14.3 14 3 decreased palatine bone horizontal plate size 0.249497727809368 0.471420887144553 0.665765563226206 0.636363636363636 14.3 14 3 abnormal phrenic nerve innervation pattern to diaphragm 0.249497727809368 0.471420887144553 0.665765563226206 0.636363636363636 14.3 14 3 chylous ascites 0.249497727809368 0.471420887144553 0.665765563226206 0.636363636363636 14.3 14 3 abnormal hair follicle morphology 0.0137186604970396 0.0651865673092378 0.664255890747235 0.634920634920635 14.3 14 3 skin lesions 0.0137186604970396 0.0651865673092378 0.664255890747235 0.634920634920635 14.3 14 3 decreased kidney weight 0.0242065587238374 0.102317442354368 0.663936536953607 0.634615384615385 14.3 14 3 abnormal cholesterol homeostasis 0.0434322083768479 0.157374535087267 0.663445822587787 0.634146341463415 14.3 14 3 abnormal lactation 0.0800105811385898 0.237501575873797 0.662595251020367 0.633333333333333 14.3 14 3 abnormal respiratory system physiology 0.0300872324076091 0.116529776262156 0.661883548280281 0.63265306122449 14.3 14 3 abnormal retinal outer nuclear layer morphology 0.0543547290225489 0.180724974212933 0.660759807111723 0.631578947368421 14.3 14 3 short vibrissae 0.154711104294615 0.366140758480166 0.660759807111723 0.631578947368421 14.3 14 3 decreased grooming behavior 0.154711104294615 0.366140758480166 0.660759807111723 0.631578947368421 14.3 14 3 increased susceptibility to ischemic brain injury 0.154711104294615 0.366140758480166 0.660759807111723 0.631578947368421 14.3 14 3 osteoarthritis 0.154711104294615 0.366140758480166 0.660759807111723 0.631578947368421 14.3 14 3 abnormal photoreceptor inner segment morphology 0.154711104294615 0.366140758480166 0.660759807111723 0.631578947368421 14.3 14 3 decreased liver regeneration 0.154711104294615 0.366140758480166 0.660759807111723 0.631578947368421 14.3 14 3 thin interventricular septum 0.154711104294615 0.366140758480166 0.660759807111723 0.631578947368421 14.3 14 3 hydronephrosis 0.0060222285635988 0.0345965209052009 0.660104291430065 0.630952380952381 14.3 14 3 decreased exploration in new environment 0.0060222285635988 0.0345965209052009 0.660104291430065 0.630952380952381 14.3 14 3 decreased IgG level 0.00179535478093794 0.0125624332421466 0.659767675269213 0.630630630630631 14.3 14 3 thick epidermis 0.012852363348134 0.0638128818931804 0.657613331839763 0.628571428571429 14.3 14 3 increased bone mineral density 0.00192591139531505 0.0134193406046112 0.657348805157607 0.628318584070796 14.3 14 3 abnormal eye electrophysiology 0.00138265437327907 0.0102057945208656 0.657119257210281 0.628099173553719 14.3 14 3 decreased oxygen consumption 0.0466440117593525 0.166053585824018 0.65691818032619 0.627906976744186 14.3 14 3 abnormal colon morphology 0.0225408847174612 0.0973445325254942 0.656093424293138 0.627118644067797 14.3 14 3 abnormal cardiovascular system morphology 0.0400757524821393 0.145849940452555 0.65387689245431 0.625 14.3 14 3 impaired ovarian folliculogenesis 0.058192381989856 0.184164822137108 0.65387689245431 0.625 14.3 14 3 abnormal pancreatic beta cell morphology 0.058192381989856 0.184164822137108 0.65387689245431 0.625 14.3 14 3 decreased metastatic potential 0.12873074316231 0.317016499802927 0.65387689245431 0.625 14.3 14 3 abnormal vasodilation 0.12873074316231 0.317016499802927 0.65387689245431 0.625 14.3 14 3 abnormal inner cell mass apoptosis 0.12873074316231 0.317016499802927 0.65387689245431 0.625 14.3 14 3 abnormal molar crown morphology 0.200549477741026 0.445615744422333 0.65387689245431 0.625 14.3 14 3 sepsis 0.200549477741026 0.445615744422333 0.65387689245431 0.625 14.3 14 3 decreased circulating growth hormone level 0.200549477741026 0.445615744422333 0.65387689245431 0.625 14.3 14 3 decreased circulating prolactin level 0.200549477741026 0.445615744422333 0.65387689245431 0.625 14.3 14 3 abnormal fertilization 0.200549477741026 0.445615744422333 0.65387689245431 0.625 14.3 14 3 decreased midbrain size 0.200549477741026 0.445615744422333 0.65387689245431 0.625 14.3 14 3 absent pre-B cells 0.338857478793198 0.579916049878281 0.65387689245431 0.625 14.3 14 3 abnormal hypoglossal nerve morphology 0.338857478793198 0.579916049878281 0.65387689245431 0.625 14.3 14 3 poor grooming 0.338857478793198 0.579916049878281 0.65387689245431 0.625 14.3 14 3 abnormal erythrocyte cell number 0.338857478793198 0.579916049878281 0.65387689245431 0.625 14.3 14 3 abnormal atrial thrombosis 0.338857478793198 0.579916049878281 0.65387689245431 0.625 14.3 14 3 abnormal hepatobiliary system morphology 0.338857478793198 0.579916049878281 0.65387689245431 0.625 14.3 14 3 coarse hair 0.338857478793198 0.579916049878281 0.65387689245431 0.625 14.3 14 3 abnormal parturition 0.338857478793198 0.579916049878281 0.65387689245431 0.625 14.3 14 3 altered response to CNS ischemic injury 0.338857478793198 0.579916049878281 0.65387689245431 0.625 14.3 14 3 abnormal soft palate morphology 0.338857478793198 0.579916049878281 0.65387689245431 0.625 14.3 14 3 liver failure 0.338857478793198 0.579916049878281 0.65387689245431 0.625 14.3 14 3 hair follicle degeneration 0.338857478793198 0.579916049878281 0.65387689245431 0.625 14.3 14 3 abnormal thermosensation 0.338857478793198 0.579916049878281 0.65387689245431 0.625 14.3 14 3 abnormal forelimb zeugopod morphology 0.338857478793198 0.579916049878281 0.65387689245431 0.625 14.3 14 3 lymph node inflammation 0.338857478793198 0.579916049878281 0.65387689245431 0.625 14.3 14 3 abnormal miscarriage rate 0.338857478793198 0.579916049878281 0.65387689245431 0.625 14.3 14 3 tau protein deposits 0.338857478793198 0.579916049878281 0.65387689245431 0.625 14.3 14 3 abnormal hair follicle melanocyte morphology 0.338857478793198 0.579916049878281 0.65387689245431 0.625 14.3 14 3 decreased susceptibility to autoimmune disorder 0.338857478793198 0.579916049878281 0.65387689245431 0.625 14.3 14 3 abnormal ilium morphology 0.338857478793198 0.579916049878281 0.65387689245431 0.625 14.3 14 3 choroidal neovascularization 0.338857478793198 0.579916049878281 0.65387689245431 0.625 14.3 14 3 hypergranulosis 0.338857478793198 0.579916049878281 0.65387689245431 0.625 14.3 14 3 decreased hippocampus pyramidal cell number 0.338857478793198 0.579916049878281 0.65387689245431 0.625 14.3 14 3 abnormal sensory neuron physiology 0.338857478793198 0.579916049878281 0.65387689245431 0.625 14.3 14 3 abnormal brain ependyma morphology 0.338857478793198 0.579916049878281 0.65387689245431 0.625 14.3 14 3 decreased quadriceps weight 0.338857478793198 0.579916049878281 0.65387689245431 0.625 14.3 14 3 increased heart right ventricle size 0.338857478793198 0.579916049878281 0.65387689245431 0.625 14.3 14 3 abnormal heart right ventricle pressure 0.338857478793198 0.579916049878281 0.65387689245431 0.625 14.3 14 3 abnormal bronchiole epithelium morphology 0.338857478793198 0.579916049878281 0.65387689245431 0.625 14.3 14 3 abnormal pulmonary acinus morphology 0.338857478793198 0.579916049878281 0.65387689245431 0.625 14.3 14 3 abnormal bronchus epithelium morphology 0.338857478793198 0.579916049878281 0.65387689245431 0.625 14.3 14 3 abnormal kidney mesenchyme morphology 0.338857478793198 0.579916049878281 0.65387689245431 0.625 14.3 14 3 abnormal heart echocardiography feature 0.338857478793198 0.579916049878281 0.65387689245431 0.625 14.3 14 3 shortened PQ interval 0.338857478793198 0.579916049878281 0.65387689245431 0.625 14.3 14 3 small thymus medulla 0.338857478793198 0.579916049878281 0.65387689245431 0.625 14.3 14 3 decreased white adipose tissue mass 0.338857478793198 0.579916049878281 0.65387689245431 0.625 14.3 14 3 decreased basal metabolism 0.338857478793198 0.579916049878281 0.65387689245431 0.625 14.3 14 3 hyperkeratosis 0.0169096165419245 0.0747116716661405 0.651981597113862 0.623188405797101 14.3 14 3 increased osteoclast cell number 0.0240680046180253 0.101818301849214 0.651733033790525 0.622950819672131 14.3 14 3 abnormal long bone metaphysis morphology 0.0727101810600362 0.222742087914828 0.650342422765367 0.621621621621622 14.3 14 3 abnormal pancreatic beta cell physiology 0.0727101810600362 0.222742087914828 0.650342422765367 0.621621621621622 14.3 14 3 abnormal microglial cell morphology 0.107928324639239 0.293697373955128 0.64936739664428 0.620689655172414 14.3 14 3 decreased heart rate 0.00558114857949353 0.0322113853630862 0.648645877314675 0.62 14.3 14 3 vascular ring 0.164391077484446 0.387972300989145 0.647649493478554 0.619047619047619 14.3 14 3 increased circulating calcium level 0.0366341752509519 0.136930895472191 0.646743689991172 0.618181818181818 14.3 14 3 abnormal retinal photoreceptor morphology 0.0910032350605748 0.266946400015542 0.646184223131318 0.617647058823529 14.3 14 3 decreased pancreatic beta cell number 0.0910032350605748 0.266946400015542 0.646184223131318 0.617647058823529 14.3 14 3 abnormal innervation 0.0528541175140425 0.180724974212933 0.645529527869787 0.617021276595745 14.3 14 3 decreased IgA level 0.045223117715333 0.163625462279114 0.643817247955013 0.615384615384615 14.3 14 3 increased susceptibility to injury 0.045223117715333 0.163625462279114 0.643817247955013 0.615384615384615 14.3 14 3 small lens 0.0770739027805222 0.233521721274725 0.643817247955013 0.615384615384615 14.3 14 3 abnormal leukocyte adhesion 0.0770739027805222 0.233521721274725 0.643817247955013 0.615384615384615 14.3 14 3 abnormal circulating hormone level 0.0770739027805222 0.233521721274725 0.643817247955013 0.615384615384615 14.3 14 3 abnormal leukocyte cell number 0.136393037039276 0.329876207715314 0.643817247955013 0.615384615384615 14.3 14 3 abnormal kidney cortex morphology 0.136393037039276 0.329876207715314 0.643817247955013 0.615384615384615 14.3 14 3 small seminal vesicle 0.136393037039276 0.329876207715314 0.643817247955013 0.615384615384615 14.3 14 3 pulmonary edema 0.136393037039276 0.329876207715314 0.643817247955013 0.615384615384615 14.3 14 3 excessive scratching 0.262767304450991 0.494054172200937 0.643817247955013 0.615384615384615 14.3 14 3 abnormal digestion 0.262767304450991 0.494054172200937 0.643817247955013 0.615384615384615 14.3 14 3 abnormal lung interstitium morphology 0.262767304450991 0.494054172200937 0.643817247955013 0.615384615384615 14.3 14 3 abnormal intercostal muscle morphology 0.262767304450991 0.494054172200937 0.643817247955013 0.615384615384615 14.3 14 3 absent lateral semicircular canal 0.262767304450991 0.494054172200937 0.643817247955013 0.615384615384615 14.3 14 3 abnormal dopaminergic neuron morphology 0.262767304450991 0.494054172200937 0.643817247955013 0.615384615384615 14.3 14 3 abnormal afterhyperpolarization 0.262767304450991 0.494054172200937 0.643817247955013 0.615384615384615 14.3 14 3 decreased alcohol consumption 0.262767304450991 0.494054172200937 0.643817247955013 0.615384615384615 14.3 14 3 increased circulating thyroid-stimulating hormone level 0.262767304450991 0.494054172200937 0.643817247955013 0.615384615384615 14.3 14 3 increased circulating thyroxine level 0.262767304450991 0.494054172200937 0.643817247955013 0.615384615384615 14.3 14 3 decreased T cell proliferation 0.00133599540177125 0.00990548006529356 0.643273483387483 0.614864864864865 14.3 14 3 increased susceptibility to pharmacologically induced seizures 0.00878681656045575 0.046509624625736 0.642978944246738 0.614583333333333 14.3 14 3 abnormal epidermis stratum corneum morphology 0.0558470999682398 0.180724974212933 0.640532466077691 0.612244897959184 14.3 14 3 abnormal epidermis stratum granulosum morphology 0.0960631805645648 0.27610057028438 0.639346294844214 0.611111111111111 14.3 14 3 reduced long term depression 0.0960631805645648 0.27610057028438 0.639346294844214 0.611111111111111 14.3 14 3 abnormal heart shape 0.211166325187259 0.454023698747277 0.639346294844214 0.611111111111111 14.3 14 3 abnormal retinal rod cell morphology 0.211166325187259 0.454023698747277 0.639346294844214 0.611111111111111 14.3 14 3 decreased activity of thyroid 0.211166325187259 0.454023698747277 0.639346294844214 0.611111111111111 14.3 14 3 increased susceptibility to autoimmune disorder 0.211166325187259 0.454023698747277 0.639346294844214 0.611111111111111 14.3 14 3 abnormal humoral immune response 0.00846800359174061 0.0454458660937536 0.637685655117346 0.60952380952381 14.3 14 3 abnormal pulmonary artery morphology 0.17296270528838 0.3915254240745 0.636819234390284 0.608695652173913 14.3 14 3 abnormal innervation pattern to muscle 0.17296270528838 0.3915254240745 0.636819234390284 0.608695652173913 14.3 14 3 hypotension 0.17296270528838 0.3915254240745 0.636819234390284 0.608695652173913 14.3 14 3 conjunctivitis 0.17296270528838 0.3915254240745 0.636819234390284 0.608695652173913 14.3 14 3 abnormal hepatocyte physiology 0.17296270528838 0.3915254240745 0.636819234390284 0.608695652173913 14.3 14 3 diarrhea 0.119881684666733 0.301370076410811 0.634062441167815 0.606060606060606 14.3 14 3 abnormal blood homeostasis 0.00808848511244781 0.0439783753381725 0.633228148482068 0.605263157894737 14.3 14 3 abnormal compact bone morphology 0.100855207517517 0.279373417260382 0.633228148482068 0.605263157894737 14.3 14 3 impaired adaptive thermogenesis 0.125271119390054 0.313335253376329 0.627721816756137 0.6 14.3 14 3 abnormal hair cycle 0.149804939890212 0.360386642144006 0.627721816756137 0.6 14.3 14 3 arrested T cell differentiation 0.149804939890212 0.360386642144006 0.627721816756137 0.6 14.3 14 3 abnormal microglial cell physiology 0.149804939890212 0.360386642144006 0.627721816756137 0.6 14.3 14 3 abnormal inner ear vestibule morphology 0.180603483170688 0.406746187765583 0.627721816756137 0.6 14.3 14 3 brain inflammation 0.220231130453135 0.454023698747277 0.627721816756137 0.6 14.3 14 3 abnormal physiological neovascularization 0.220231130453135 0.454023698747277 0.627721816756137 0.6 14.3 14 3 abnormal heart right ventricle morphology 0.220231130453135 0.454023698747277 0.627721816756137 0.6 14.3 14 3 decreased circulating VLDL cholesterol level 0.220231130453135 0.454023698747277 0.627721816756137 0.6 14.3 14 3 abnormal enteric neuron morphology 0.273261080958561 0.512428902287538 0.627721816756137 0.6 14.3 14 3 placental labyrinth hypoplasia 0.273261080958561 0.512428902287538 0.627721816756137 0.6 14.3 14 3 abnormal respiratory system morphology 0.273261080958561 0.512428902287538 0.627721816756137 0.6 14.3 14 3 liver vascular congestion 0.273261080958561 0.512428902287538 0.627721816756137 0.6 14.3 14 3 lactation failure 0.273261080958561 0.512428902287538 0.627721816756137 0.6 14.3 14 3 abnormal microglial cell activation 0.273261080958561 0.512428902287538 0.627721816756137 0.6 14.3 14 3 absent palatine bone horizontal plate 0.349480230565649 0.593400732786384 0.627721816756137 0.6 14.3 14 3 abnormal optic nerve innervation 0.349480230565649 0.593400732786384 0.627721816756137 0.6 14.3 14 3 abnormal pituitary secretion 0.349480230565649 0.593400732786384 0.627721816756137 0.6 14.3 14 3 abnormal respiratory mechanics 0.349480230565649 0.593400732786384 0.627721816756137 0.6 14.3 14 3 abnormal PNS synaptic transmission 0.349480230565649 0.593400732786384 0.627721816756137 0.6 14.3 14 3 abnormal neuron specification 0.349480230565649 0.593400732786384 0.627721816756137 0.6 14.3 14 3 rickets 0.349480230565649 0.593400732786384 0.627721816756137 0.6 14.3 14 3 abnormal scala media morphology 0.349480230565649 0.593400732786384 0.627721816756137 0.6 14.3 14 3 intestinal hypoperistalsis 0.349480230565649 0.593400732786384 0.627721816756137 0.6 14.3 14 3 peritoneal inflammation 0.349480230565649 0.593400732786384 0.627721816756137 0.6 14.3 14 3 abnormal hypaxial muscle morphology 0.349480230565649 0.593400732786384 0.627721816756137 0.6 14.3 14 3 lymphedema 0.349480230565649 0.593400732786384 0.627721816756137 0.6 14.3 14 3 abnormal submandibular gland morphology 0.349480230565649 0.593400732786384 0.627721816756137 0.6 14.3 14 3 increased atrioventricular cushion size 0.349480230565649 0.593400732786384 0.627721816756137 0.6 14.3 14 3 increased left ventricle diastolic pressure 0.349480230565649 0.593400732786384 0.627721816756137 0.6 14.3 14 3 abnormal pillar cell morphology 0.349480230565649 0.593400732786384 0.627721816756137 0.6 14.3 14 3 abnormal hindlimb zeugopod morphology 0.349480230565649 0.593400732786384 0.627721816756137 0.6 14.3 14 3 abnormal placental transport 0.349480230565649 0.593400732786384 0.627721816756137 0.6 14.3 14 3 abnormal utricular macula morphology 0.349480230565649 0.593400732786384 0.627721816756137 0.6 14.3 14 3 absent coat pigmentation 0.349480230565649 0.593400732786384 0.627721816756137 0.6 14.3 14 3 decreased thyroxine level 0.349480230565649 0.593400732786384 0.627721816756137 0.6 14.3 14 3 vascular smooth muscle hyperplasia 0.349480230565649 0.593400732786384 0.627721816756137 0.6 14.3 14 3 decreased macrophage cytokine production 0.349480230565649 0.593400732786384 0.627721816756137 0.6 14.3 14 3 increased sensitivity to induced morbidity/mortality 0.00186163295361514 0.0130078987980833 0.625447462347601 0.597826086956522 14.3 14 3 increased percent body fat/body weight 0.0787520733217805 0.23522621969307 0.623697958956419 0.596153846153846 14.3 14 3 increased systemic arterial blood pressure 0.0927750238462639 0.271983349225199 0.623269888977725 0.595744680851064 14.3 14 3 abnormal response to infection 0.0374925791488514 0.139719536528491 0.622424586234989 0.594936708860759 14.3 14 3 polydipsia 0.155700727837656 0.36781154842941 0.621183047831594 0.59375 14.3 14 3 abnormal long term potentiation 0.155700727837656 0.36781154842941 0.621183047831594 0.59375 14.3 14 3 abnormal serotonin level 0.155700727837656 0.36781154842941 0.621183047831594 0.59375 14.3 14 3 abnormal cochlea morphology 0.0817870977092974 0.242485584686385 0.61997216469742 0.592592592592593 14.3 14 3 polyphagia 0.0817870977092974 0.242485584686385 0.61997216469742 0.592592592592593 14.3 14 3 wrinkled skin 0.187454905995714 0.419852584697202 0.61997216469742 0.592592592592593 14.3 14 3 abnormal CD4-positive, alpha-beta T cell physiology 0.0528202813011136 0.180724974212933 0.618880664407459 0.591549295774648 14.3 14 3 abnormal circadian rhythm 0.113788695905672 0.293697373955128 0.61821088013862 0.590909090909091 14.3 14 3 intestinal inflammation 0.228060124498239 0.454023698747277 0.61821088013862 0.590909090909091 14.3 14 3 parakeratosis 0.228060124498239 0.454023698747277 0.61821088013862 0.590909090909091 14.3 14 3 abnormal circulating lipid level 0.228060124498239 0.454023698747277 0.61821088013862 0.590909090909091 14.3 14 3 abnormal blood-brain barrier function 0.228060124498239 0.454023698747277 0.61821088013862 0.590909090909091 14.3 14 3 rough coat 0.228060124498239 0.454023698747277 0.61821088013862 0.590909090909091 14.3 14 3 increased bone volume 0.228060124498239 0.454023698747277 0.61821088013862 0.590909090909091 14.3 14 3 acanthosis 0.135040833076947 0.32724215516698 0.61699152929022 0.58974358974359 14.3 14 3 increased autoantibody level 0.135040833076947 0.32724215516698 0.61699152929022 0.58974358974359 14.3 14 3 impaired macrophage chemotaxis 0.135040833076947 0.32724215516698 0.61699152929022 0.58974358974359 14.3 14 3 abnormal immune system physiology 0.0159968418440722 0.0732637664313417 0.615909847085995 0.588709677419355 14.3 14 3 decreased susceptibility to injury 0.0638434062278637 0.197402701046378 0.61541354583935 0.588235294117647 14.3 14 3 decreased regulatory T cell number 0.16113661267553 0.380472068372454 0.61541354583935 0.588235294117647 14.3 14 3 hydroureter 0.28176630076228 0.526231832866321 0.61541354583935 0.588235294117647 14.3 14 3 enlarged sebaceous gland 0.28176630076228 0.526231832866321 0.61541354583935 0.588235294117647 14.3 14 3 abnormal touch/ nociception 0.28176630076228 0.526231832866321 0.61541354583935 0.588235294117647 14.3 14 3 abnormal electroretinogram waveform feature 0.28176630076228 0.526231832866321 0.61541354583935 0.588235294117647 14.3 14 3 abnormal immune system morphology 0.117669809906877 0.295959203380543 0.614075690304917 0.58695652173913 14.3 14 3 abnormal circulating glucose level 0.193631009938824 0.43159241686633 0.613291430164042 0.586206896551724 14.3 14 3 enlarged epididymis 0.193631009938824 0.43159241686633 0.613291430164042 0.586206896551724 14.3 14 3 scaly skin 0.139477639081356 0.33717262120007 0.612411528542573 0.585365853658537 14.3 14 3 polyuria 0.0583184802592229 0.184446560260416 0.611417353983251 0.584415584415584 14.3 14 3 decreased inflammatory response 0.0516473069826424 0.178682442446903 0.610285099624022 0.583333333333333 14.3 14 3 increased food intake 0.0516473069826424 0.178682442446903 0.610285099624022 0.583333333333333 14.3 14 3 abnormal kidney physiology 0.121358944274782 0.303855434205858 0.610285099624022 0.583333333333333 14.3 14 3 abnormal osteoclast morphology 0.121358944274782 0.303855434205858 0.610285099624022 0.583333333333333 14.3 14 3 small lymph nodes 0.234887452264877 0.454023698747277 0.610285099624022 0.583333333333333 14.3 14 3 prolonged QT interval 0.234887452264877 0.454023698747277 0.610285099624022 0.583333333333333 14.3 14 3 abnormal cellular extravasation 0.234887452264877 0.454023698747277 0.610285099624022 0.583333333333333 14.3 14 3 abnormal rectum morphology 0.35699107962123 0.603476255900653 0.610285099624022 0.583333333333333 14.3 14 3 abnormal mating frequency 0.35699107962123 0.603476255900653 0.610285099624022 0.583333333333333 14.3 14 3 increased litter size 0.35699107962123 0.603476255900653 0.610285099624022 0.583333333333333 14.3 14 3 increased circulating parathyroid hormone level 0.35699107962123 0.603476255900653 0.610285099624022 0.583333333333333 14.3 14 3 abnormal gastrocnemius morphology 0.35699107962123 0.603476255900653 0.610285099624022 0.583333333333333 14.3 14 3 absent tail 0.35699107962123 0.603476255900653 0.610285099624022 0.583333333333333 14.3 14 3 increased hepatocyte proliferation 0.35699107962123 0.603476255900653 0.610285099624022 0.583333333333333 14.3 14 3 stria vascularis degeneration 0.35699107962123 0.603476255900653 0.610285099624022 0.583333333333333 14.3 14 3 abnormal B cell proliferation 0.35699107962123 0.603476255900653 0.610285099624022 0.583333333333333 14.3 14 3 abnormal palatine bone morphology 0.35699107962123 0.603476255900653 0.610285099624022 0.583333333333333 14.3 14 3 reduced cerebellar foliation 0.35699107962123 0.603476255900653 0.610285099624022 0.583333333333333 14.3 14 3 abnormal aorta elastic tissue morphology 0.35699107962123 0.603476255900653 0.610285099624022 0.583333333333333 14.3 14 3 increased type II pneumocyte number 0.35699107962123 0.603476255900653 0.610285099624022 0.583333333333333 14.3 14 3 decreased food intake 0.0600800667084014 0.188698441839834 0.609181509932116 0.582278481012658 14.3 14 3 abnormal T-helper 2 physiology 0.106023707729466 0.293363707427193 0.608699943521103 0.581818181818182 14.3 14 3 abnormal homeostasis 0.143648699920063 0.346532266403339 0.608257574376102 0.581395348837209 14.3 14 3 abnormal CD8-positive, alpha beta T cell morphology 0.199224671915288 0.443861505946511 0.607472725893036 0.580645161290323 14.3 14 3 abnormal digestive system physiology 0.124868494773329 0.312485292503677 0.606797756197599 0.58 14.3 14 3 abnormal trabecular bone morphology 0.0285950881571139 0.113174672698204 0.606621923755931 0.579831932773109 14.3 14 3 abnormal reproductive system physiology 0.170820425111696 0.3915254240745 0.605696489852413 0.578947368421053 14.3 14 3 enlarged adrenal glands 0.288792253914643 0.526231832866321 0.605696489852413 0.578947368421053 14.3 14 3 decreased eye pigmentation 0.288792253914643 0.526231832866321 0.605696489852413 0.578947368421053 14.3 14 3 altered response to myocardial infarction 0.147575606804799 0.355539294844491 0.604472860579984 0.577777777777778 14.3 14 3 decreased osteoclast cell number 0.147575606804799 0.355539294844491 0.604472860579984 0.577777777777778 14.3 14 3 decreased sensitivity to xenobiotic induced morbidity/mortality 0.204312286426765 0.452628296403065 0.602359319109425 0.575757575757576 14.3 14 3 head bobbing 0.175148299520462 0.394638944798142 0.601566741057965 0.575 14.3 14 3 abnormal stria vascularis morphology 0.246206107639059 0.467866839382856 0.597830301672512 0.571428571428571 14.3 14 3 abnormal vasoconstriction 0.362534308410256 0.611392604861363 0.597830301672512 0.571428571428571 14.3 14 3 abnormal olfactory system physiology 0.362534308410256 0.611392604861363 0.597830301672512 0.571428571428571 14.3 14 3 abnormal kidney medulla morphology 0.362534308410256 0.611392604861363 0.597830301672512 0.571428571428571 14.3 14 3 decreased coping response 0.362534308410256 0.611392604861363 0.597830301672512 0.571428571428571 14.3 14 3 abnormal prepulse inhibition 0.362534308410256 0.611392604861363 0.597830301672512 0.571428571428571 14.3 14 3 amyloid beta deposits 0.362534308410256 0.611392604861363 0.597830301672512 0.571428571428571 14.3 14 3 abnormal decidualization 0.362534308410256 0.611392604861363 0.597830301672512 0.571428571428571 14.3 14 3 increased fluid intake 0.1547726663485 0.366140758480166 0.597830301672512 0.571428571428571 14.3 14 3 hypoalgesia 0.294684534411388 0.526231832866321 0.597830301672512 0.571428571428571 14.3 14 3 abnormal bile salt homeostasis 0.294684534411388 0.526231832866321 0.597830301672512 0.571428571428571 14.3 14 3 increased keratinocyte proliferation 0.294684534411388 0.526231832866321 0.597830301672512 0.571428571428571 14.3 14 3 increased susceptibility to bacterial infection induced morbidity/mortality 0.104883237948396 0.290369565271713 0.595754502013927 0.569444444444444 14.3 14 3 abnormal photoreceptor outer segment morphology 0.182938178886366 0.41163158749872 0.594433538594827 0.568181818181818 14.3 14 3 decreased macrophage cell number 0.182938178886366 0.41163158749872 0.594433538594827 0.568181818181818 14.3 14 3 increased white adipose tissue amount 0.213212716999812 0.454023698747277 0.593790907742292 0.567567567567568 14.3 14 3 increased trabecular bone volume 0.213212716999812 0.454023698747277 0.593790907742292 0.567567567567568 14.3 14 3 abnormal synaptic transmission 0.250942024617778 0.47396984528225 0.592848382491907 0.566666666666667 14.3 14 3 delayed wound healing 0.186453142772097 0.419350987925489 0.59133214621955 0.565217391304348 14.3 14 3 pancreas inflammation 0.299686769471057 0.532859784888674 0.59133214621955 0.565217391304348 14.3 14 3 decreased epididymis weight 0.299686769471057 0.532859784888674 0.59133214621955 0.565217391304348 14.3 14 3 abnormal urine homeostasis 0.0890740282572899 0.262466876610427 0.588489203208879 0.5625 14.3 14 3 abnormal lymph node morphology 0.189744834135179 0.423499573720286 0.588489203208879 0.5625 14.3 14 3 abnormal hair shaft morphology 0.189744834135179 0.423499573720286 0.588489203208879 0.5625 14.3 14 3 abnormal extraembryonic endoderm formation 0.366747427952534 0.612889472507341 0.588489203208879 0.5625 14.3 14 3 small epididymis 0.366747427952534 0.612889472507341 0.588489203208879 0.5625 14.3 14 3 abnormal wound healing 0.366747427952534 0.612889472507341 0.588489203208879 0.5625 14.3 14 3 abnormal level of surface class II molecules 0.366747427952534 0.612889472507341 0.588489203208879 0.5625 14.3 14 3 abnormal pancreatic alpha cell morphology 0.366747427952534 0.612889472507341 0.588489203208879 0.5625 14.3 14 3 decreased susceptibility to induced arthritis 0.166972752274747 0.3915254240745 0.587342050765976 0.56140350877193 14.3 14 3 abnormal response/metabolism to endogenous compounds 0.115018340030955 0.293697373955128 0.586894381519966 0.560975609756098 14.3 14 3 kidney inflammation 0.192832521080537 0.430198113172947 0.585873695639061 0.56 14.3 14 3 abnormal inhibitory postsynaptic currents 0.150011900783757 0.360710104591199 0.584642868547383 0.558823529411765 14.3 14 3 abnormal bone remodeling 0.259001473178331 0.489006576494192 0.584642868547383 0.558823529411765 14.3 14 3 abnormal systemic arterial blood pressure 0.262451066194197 0.494054172200937 0.581223904403831 0.555555555555556 14.3 14 3 abnormal head movements 0.472231766651441 0.612889472507341 0.581223904403831 0.555555555555556 14.3 14 3 deformed nails 0.472231766651441 0.612889472507341 0.581223904403831 0.555555555555556 14.3 14 3 small geniculate ganglion 0.472231766651441 0.612889472507341 0.581223904403831 0.555555555555556 14.3 14 3 thick dermal layer 0.370016270231057 0.612889472507341 0.581223904403831 0.555555555555556 14.3 14 3 wavy vibrissae 0.472231766651441 0.612889472507341 0.581223904403831 0.555555555555556 14.3 14 3 abnormal ion homeostasis 0.472231766651441 0.612889472507341 0.581223904403831 0.555555555555556 14.3 14 3 eye inflammation 0.370016270231057 0.612889472507341 0.581223904403831 0.555555555555556 14.3 14 3 decreased circulating bicarbonate level 0.472231766651441 0.612889472507341 0.581223904403831 0.555555555555556 14.3 14 3 abnormal lens capsule morphology 0.472231766651441 0.612889472507341 0.581223904403831 0.555555555555556 14.3 14 3 brittle hair 0.472231766651441 0.612889472507341 0.581223904403831 0.555555555555556 14.3 14 3 decreased heart rate variability 0.370016270231057 0.612889472507341 0.581223904403831 0.555555555555556 14.3 14 3 abnormal proprioceptive neuron morphology 0.472231766651441 0.612889472507341 0.581223904403831 0.555555555555556 14.3 14 3 abnormal stria vascularis vasculature morphology 0.472231766651441 0.612889472507341 0.581223904403831 0.555555555555556 14.3 14 3 absent cochlear outer hair cells 0.472231766651441 0.612889472507341 0.581223904403831 0.555555555555556 14.3 14 3 increased stomach mucosa thickness 0.472231766651441 0.612889472507341 0.581223904403831 0.555555555555556 14.3 14 3 hemothorax 0.472231766651441 0.612889472507341 0.581223904403831 0.555555555555556 14.3 14 3 abnormal oxygen consumption 0.472231766651441 0.612889472507341 0.581223904403831 0.555555555555556 14.3 14 3 positive geotaxis 0.472231766651441 0.612889472507341 0.581223904403831 0.555555555555556 14.3 14 3 abnormal retinal development 0.472231766651441 0.612889472507341 0.581223904403831 0.555555555555556 14.3 14 3 abnormal hyoid bone lesser horn morphology 0.472231766651441 0.612889472507341 0.581223904403831 0.555555555555556 14.3 14 3 abnormal hippocampus granule cell morphology 0.472231766651441 0.612889472507341 0.581223904403831 0.555555555555556 14.3 14 3 abnormal incisor color 0.472231766651441 0.612889472507341 0.581223904403831 0.555555555555556 14.3 14 3 abnormal heart left ventricle pressure 0.472231766651441 0.612889472507341 0.581223904403831 0.555555555555556 14.3 14 3 abnormal macrophage chemotaxis 0.370016270231057 0.612889472507341 0.581223904403831 0.555555555555556 14.3 14 3 decreased airway resistance 0.472231766651441 0.612889472507341 0.581223904403831 0.555555555555556 14.3 14 3 abnormal ureteric bud invasion 0.472231766651441 0.612889472507341 0.581223904403831 0.555555555555556 14.3 14 3 decreased fluid intake 0.370016270231057 0.612889472507341 0.581223904403831 0.555555555555556 14.3 14 3 abnormal coronary sinus connection 0.472231766651441 0.612889472507341 0.581223904403831 0.555555555555556 14.3 14 3 decreased bone mineral density of femur 0.472231766651441 0.612889472507341 0.581223904403831 0.555555555555556 14.3 14 3 increased bone mineralization 0.472231766651441 0.612889472507341 0.581223904403831 0.555555555555556 14.3 14 3 impaired leukocyte tethering or rolling 0.370016270231057 0.612889472507341 0.581223904403831 0.555555555555556 14.3 14 3 absent long term depression 0.310913920193195 0.552230186705157 0.577215463683804 0.551724137931034 14.3 14 3 abnormal CD8-positive, alpha-beta T cell physiology 0.310913920193195 0.552230186705157 0.577215463683804 0.551724137931034 14.3 14 3 increased retinal apoptosis 0.310913920193195 0.552230186705157 0.577215463683804 0.551724137931034 14.3 14 3 abnormal eye physiology 0.205748625833864 0.452628296403065 0.575411665359792 0.55 14.3 14 3 abnormal skin pigmentation 0.268426359627061 0.504503641535561 0.575411665359792 0.55 14.3 14 3 abnormal hearing physiology 0.372589182589819 0.612889472507341 0.575411665359792 0.55 14.3 14 3 decreased sensitivity to induced morbidity/mortality 0.273400572583398 0.512497305426678 0.570656197051034 0.545454545454545 14.3 14 3 intestinal ulcer 0.374633826307165 0.612889472507341 0.570656197051034 0.545454545454545 14.3 14 3 variable body spotting 0.469459233873187 0.612889472507341 0.570656197051034 0.545454545454545 14.3 14 3 abnormal nerve fiber response 0.469459233873187 0.612889472507341 0.570656197051034 0.545454545454545 14.3 14 3 abnormal lymph circulation 0.469459233873187 0.612889472507341 0.570656197051034 0.545454545454545 14.3 14 3 abnormal retinal layer morphology 0.374633826307165 0.612889472507341 0.570656197051034 0.545454545454545 14.3 14 3 abnormal hair medulla 0.469459233873187 0.612889472507341 0.570656197051034 0.545454545454545 14.3 14 3 enlarged placenta 0.469459233873187 0.612889472507341 0.570656197051034 0.545454545454545 14.3 14 3 abnormal crista ampullaris neuroepithelium morphology 0.469459233873187 0.612889472507341 0.570656197051034 0.545454545454545 14.3 14 3 decreased circulating estradiol level 0.374633826307165 0.612889472507341 0.570656197051034 0.545454545454545 14.3 14 3 decreased susceptibility to viral infection induced morbidity/mortality 0.374633826307165 0.612889472507341 0.570656197051034 0.545454545454545 14.3 14 3 abnormal extraembryonic ectoderm morphology 0.469459233873187 0.612889472507341 0.570656197051034 0.545454545454545 14.3 14 3 decreased core body temperature 0.469459233873187 0.612889472507341 0.570656197051034 0.545454545454545 14.3 14 3 increased pancreatic beta cell proliferation 0.469459233873187 0.612889472507341 0.570656197051034 0.545454545454545 14.3 14 3 decreased colon length 0.469459233873187 0.612889472507341 0.570656197051034 0.545454545454545 14.3 14 3 impaired humoral immune response 0.374633826307165 0.612889472507341 0.570656197051034 0.545454545454545 14.3 14 3 abnormal sensory capabilities/reflexes/nociception 0.376267780714725 0.612889472507341 0.566693306793735 0.541666666666667 14.3 14 3 decreased ovulation rate 0.376267780714725 0.612889472507341 0.566693306793735 0.541666666666667 14.3 14 3 abnormal T cell activation 0.218723400497937 0.454023698747277 0.565515150230754 0.540540540540541 14.3 14 3 abnormal lens fiber morphology 0.322111944909515 0.560359986876769 0.563340091960636 0.538461538461538 14.3 14 3 abnormal membranous labyrinth morphology 0.466918817319844 0.612889472507341 0.563340091960636 0.538461538461538 14.3 14 3 absent trabeculae carneae 0.466918817319844 0.612889472507341 0.563340091960636 0.538461538461538 14.3 14 3 short hair 0.466918817319844 0.612889472507341 0.563340091960636 0.538461538461538 14.3 14 3 small trigeminal ganglion 0.466918817319844 0.612889472507341 0.563340091960636 0.538461538461538 14.3 14 3 decreased luteinizing hormone level 0.466918817319844 0.612889472507341 0.563340091960636 0.538461538461538 14.3 14 3 increased renin activity 0.466918817319844 0.612889472507341 0.563340091960636 0.538461538461538 14.3 14 3 decreased Peyer's patch number 0.377576106076947 0.612889472507341 0.563340091960636 0.538461538461538 14.3 14 3 abnormal spleen germinal center morphology 0.378621950088647 0.612889472507341 0.56046590781798 0.535714285714286 14.3 14 3 abnormal axon guidance 0.325035606434386 0.564022372518685 0.559596968426014 0.534883720930233 14.3 14 3 increased circulating corticosterone level 0.326268205263481 0.565963849785851 0.557974948227678 0.533333333333333 14.3 14 3 decreased chondrocyte number 0.464560854069335 0.612889472507341 0.557974948227678 0.533333333333333 14.3 14 3 salivary gland inflammation 0.379453229422243 0.612889472507341 0.557974948227678 0.533333333333333 14.3 14 3 joint inflammation 0.464560854069335 0.612889472507341 0.557974948227678 0.533333333333333 14.3 14 3 arthritis 0.464560854069335 0.612889472507341 0.557974948227678 0.533333333333333 14.3 14 3 increased alcohol consumption 0.464560854069335 0.612889472507341 0.557974948227678 0.533333333333333 14.3 14 3 greasy coat 0.464560854069335 0.612889472507341 0.557974948227678 0.533333333333333 14.3 14 3 decreased aggression towards males 0.464560854069335 0.612889472507341 0.557974948227678 0.533333333333333 14.3 14 3 abnormal Muller cell morphology 0.464560854069335 0.612889472507341 0.557974948227678 0.533333333333333 14.3 14 3 decreased urine osmolality 0.328357803443117 0.569390056510808 0.555128137267332 0.530612244897959 14.3 14 3 distended urinary bladder 0.462351196041569 0.612889472507341 0.553872191255415 0.529411764705882 14.3 14 3 decreased vasoconstriction 0.462351196041569 0.612889472507341 0.553872191255415 0.529411764705882 14.3 14 3 decreased cytotoxic T cell cytolysis 0.380612345928154 0.612889472507341 0.553872191255415 0.529411764705882 14.3 14 3 abnormal skin physiology 0.380612345928154 0.612889472507341 0.553872191255415 0.529411764705882 14.3 14 3 abnormal tendon morphology 0.462351196041569 0.612889472507341 0.553872191255415 0.529411764705882 14.3 14 3 abnormal circulating chemokine level 0.462351196041569 0.612889472507341 0.553872191255415 0.529411764705882 14.3 14 3 abnormal reflex 0.380992496820749 0.612889472507341 0.552162709183639 0.527777777777778 14.3 14 3 impaired natural killer cell mediated cytotoxicity 0.331367048033378 0.574408036225107 0.550633172593103 0.526315789473684 14.3 14 3 flaky skin 0.460265177249295 0.612889472507341 0.550633172593103 0.526315789473684 14.3 14 3 decreased susceptibility to weight gain 0.460265177249295 0.612889472507341 0.550633172593103 0.526315789473684 14.3 14 3 increased vasoconstriction 0.458284295586094 0.612889472507341 0.548011109866469 0.523809523809524 14.3 14 3 increased bone ossification 0.458284295586094 0.612889472507341 0.548011109866469 0.523809523809524 14.3 14 3 increased susceptibility to age related obesity 0.456394251946555 0.612889472507341 0.545845058048815 0.521739130434783 14.3 14 3 abnormal crista ampullaris morphology 0.456394251946555 0.612889472507341 0.545845058048815 0.521739130434783 14.3 14 3 abnormal regulatory T cell physiology 0.456394251946555 0.612889472507341 0.545845058048815 0.521739130434783 14.3 14 3 increased susceptibility to fungal infection 0.456394251946555 0.612889472507341 0.545845058048815 0.521739130434783 14.3 14 3 abnormal stomach mucosa morphology 0.454583724602497 0.612889472507341 0.544025574521986 0.52 14.3 14 3 increased susceptibility to induced arthritis 0.451166267833776 0.612889472507341 0.541139497203567 0.517241379310345 14.3 14 3 abnormal T cell proliferation 0.44954556247521 0.612889472507341 0.539975756349365 0.516129032258065 14.3 14 3 decreased systemic arterial blood pressure 0.447976167166479 0.612889472507341 0.538953074992643 0.515151515151515 14.3 14 3 abnormal inflammatory response 0.378154698887156 0.612889472507341 0.537632111573544 0.513888888888889 14.3 14 3 abnormal NK cell physiology 0.429652780943418 0.612889472507341 0.531676948618586 0.508196721311475 14.3 14 3 increased susceptibility to parasitic infection 0.456339952041555 0.612889472507341 0.523101513963448 0.5 14.3 14 3 increased susceptibility to viral infection induced morbidity/mortality 0.515339988404803 0.646123095341203 0.523101513963448 0.5 14.3 14 3 increased circulating luteinizing hormone level 0.527065185481879 0.660657419443776 0.523101513963448 0.5 14.3 14 3 abnormal ocular fundus morphology 0.531591343128046 0.665995198202475 0.523101513963448 0.5 14.3 14 3 abnormal tectorial membrane morphology 0.531591343128046 0.665995198202475 0.523101513963448 0.5 14.3 14 3 decreased skin tensile strength 0.547941171908771 0.686305974382209 0.523101513963448 0.5 14.3 14 3 abnormal stomach glandular epithelium morphology 0.554686121852081 0.694229800305435 0.523101513963448 0.5 14.3 14 3 abnormal iron level 0.554686121852081 0.694229800305435 0.523101513963448 0.5 14.3 14 3 acidosis 0.554686121852081 0.694229800305435 0.523101513963448 0.5 14.3 14 3 mixed cellular infiltration to dermis 0.562374280186135 0.702614777480167 0.523101513963448 0.5 14.3 14 3 impaired muscle relaxation 0.562374280186135 0.702614777480167 0.523101513963448 0.5 14.3 14 3 abnormal pulmonary elastic fiber morphology 0.562374280186135 0.702614777480167 0.523101513963448 0.5 14.3 14 3 increased circulating estradiol level 0.562374280186135 0.702614777480167 0.523101513963448 0.5 14.3 14 3 abnormal intestinal lipid absorption 0.562374280186135 0.702614777480167 0.523101513963448 0.5 14.3 14 3 decreased skeletal muscle weight 0.562374280186135 0.702614777480167 0.523101513963448 0.5 14.3 14 3 abnormal urinary bladder physiology 0.562374280186135 0.702614777480167 0.523101513963448 0.5 14.3 14 3 skeletal muscle necrosis 0.571303326229431 0.713412160640417 0.523101513963448 0.5 14.3 14 3 abnormal iris pigmentation 0.571303326229431 0.713412160640417 0.523101513963448 0.5 14.3 14 3 abnormal esophagus morphology 0.581927388125144 0.72504101074946 0.523101513963448 0.5 14.3 14 3 impaired embryo implantation 0.581927388125144 0.72504101074946 0.523101513963448 0.5 14.3 14 3 abnormal corticospinal tract morphology 0.581927388125144 0.72504101074946 0.523101513963448 0.5 14.3 14 3 increased urine phosphate level 0.581927388125144 0.72504101074946 0.523101513963448 0.5 14.3 14 3 absent cochlear hair cells 0.581927388125144 0.72504101074946 0.523101513963448 0.5 14.3 14 3 increased placenta weight 0.581927388125144 0.72504101074946 0.523101513963448 0.5 14.3 14 3 abnormal amacrine cell morphology 0.581927388125144 0.72504101074946 0.523101513963448 0.5 14.3 14 3 hydrometra 0.581927388125144 0.72504101074946 0.523101513963448 0.5 14.3 14 3 decreased compensatory feeding amount 0.581927388125144 0.72504101074946 0.523101513963448 0.5 14.3 14 3 abnormal otic capsule morphology 0.594983302737233 0.737981034933367 0.523101513963448 0.5 14.3 14 3 small petrosal ganglion 0.594983302737233 0.737981034933367 0.523101513963448 0.5 14.3 14 3 abnormal immune cell physiology 0.594983302737233 0.737981034933367 0.523101513963448 0.5 14.3 14 3 decreased circulating parathyroid hormone level 0.594983302737233 0.737981034933367 0.523101513963448 0.5 14.3 14 3 delayed dark adaptation 0.594983302737233 0.737981034933367 0.523101513963448 0.5 14.3 14 3 intestinal edema 0.594983302737233 0.737981034933367 0.523101513963448 0.5 14.3 14 3 abnormal glial cell physiology 0.594983302737233 0.737981034933367 0.523101513963448 0.5 14.3 14 3 abnormal ear physiology 0.594983302737233 0.737981034933367 0.523101513963448 0.5 14.3 14 3 decreased cochlear inner hair cell number 0.594983302737233 0.737981034933367 0.523101513963448 0.5 14.3 14 3 abnormal cochlear inner hair cell physiology 0.594983302737233 0.737981034933367 0.523101513963448 0.5 14.3 14 3 decreased prolactin level 0.594983302737233 0.737981034933367 0.523101513963448 0.5 14.3 14 3 abnormal spinal cord dorsal column morphology 0.594983302737233 0.737981034933367 0.523101513963448 0.5 14.3 14 3 ventricular premature beat 0.594983302737233 0.737981034933367 0.523101513963448 0.5 14.3 14 3 impaired behavioral response to morphine 0.594983302737233 0.737981034933367 0.523101513963448 0.5 14.3 14 3 decreased macrophage apoptosis 0.594983302737233 0.737981034933367 0.523101513963448 0.5 14.3 14 3 abnormal body temperature homeostasis 0.591629691029777 0.736576004222508 0.50622727157753 0.483870967741935 14.3 14 3 autoimmune response 0.591629691029777 0.736576004222508 0.50622727157753 0.483870967741935 14.3 14 3 decreased susceptibility to bacterial infection induced morbidity/mortality 0.591629691029777 0.736576004222508 0.50622727157753 0.483870967741935 14.3 14 3 abnormal single cell response 0.604714277374915 0.749863791111715 0.503727383816653 0.481481481481481 14.3 14 3 abnormal feces composition 0.612154875709974 0.753829333330971 0.50217745340491 0.48 14.3 14 3 dry skin 0.629447423111204 0.774317104262095 0.498191918060426 0.476190476190476 14.3 14 3 decreased cochlear outer hair cell number 0.629447423111204 0.774317104262095 0.498191918060426 0.476190476190476 14.3 14 3 increased acute inflammation 0.629447423111204 0.774317104262095 0.498191918060426 0.476190476190476 14.3 14 3 altered susceptibility to infection 0.639664971994589 0.779792510579044 0.495569855333793 0.473684210526316 14.3 14 3 decreased chemically-elicited antinociception 0.639664971994589 0.779792510579044 0.495569855333793 0.473684210526316 14.3 14 3 nephrocalcinosis 0.651283688314638 0.793761967017473 0.49233083667148 0.470588235294118 14.3 14 3 abnormal rostral migratory stream morphology 0.664702989369516 0.799610903811642 0.488228079699218 0.466666666666667 14.3 14 3 abnormal insulin secretion 0.680506163101116 0.810902553635461 0.48286293596626 0.461538461538462 14.3 14 3 decreased follicle stimulating hormone level 0.680506163101116 0.810902553635461 0.48286293596626 0.461538461538462 14.3 14 3 abnormal gut flora balance 0.680506163101116 0.810902553635461 0.48286293596626 0.461538461538462 14.3 14 3 abnormal hair follicle inner root sheath morphology 0.680506163101116 0.810902553635461 0.48286293596626 0.461538461538462 14.3 14 3 abnormal response to injury 0.690813970314212 0.822988386569254 0.48286293596626 0.461538461538462 14.3 14 3 impaired behavioral response to xenobiotic 0.705773764437698 0.832838861117775 0.478264241338009 0.457142857142857 14.3 14 3 increased mast cell number 0.699586693457271 0.832044895995679 0.475546830875862 0.454545454545455 14.3 14 3 abnormal large intestine morphology 0.699586693457271 0.832044895995679 0.475546830875862 0.454545454545455 14.3 14 3 retinal detachment 0.699586693457271 0.832044895995679 0.475546830875862 0.454545454545455 14.3 14 3 patent ductus arteriosus 0.699586693457271 0.832044895995679 0.475546830875862 0.454545454545455 14.3 14 3 impaired luteinization 0.699586693457271 0.832044895995679 0.475546830875862 0.454545454545455 14.3 14 3 increased motor neuron number 0.699586693457271 0.832044895995679 0.475546830875862 0.454545454545455 14.3 14 3 increased circulating triiodothyronine level 0.699586693457271 0.832044895995679 0.475546830875862 0.454545454545455 14.3 14 3 abnormal channel response 0.702374638316354 0.832838861117775 0.475546830875862 0.454545454545455 14.3 14 3 nuclear cataracts 0.71471171751935 0.832838861117775 0.470791362567103 0.45 14.3 14 3 stomach inflammation 0.732221267170174 0.832838861117775 0.468987564243091 0.448275862068966 14.3 14 3 impaired conditioned place preference behavior 0.753443928151591 0.847731477501783 0.460329332287834 0.44 14.3 14 3 abnormal Langerhans cell physiology 0.744291985401034 0.838888225502977 0.457713824718017 0.4375 14.3 14 3 decreased circulating triiodothyronine level 0.744291985401034 0.838888225502977 0.457713824718017 0.4375 14.3 14 3 increased dopamine level 0.77493135030737 0.868698392920046 0.457713824718017 0.4375 14.3 14 3 abnormal retinal cone cell morphology 0.765472897246662 0.858288858192956 0.454870881707346 0.434782608695652 14.3 14 3 abnormal estrous cycle 0.784733873590029 0.878301692038334 0.453354645434988 0.433333333333333 14.3 14 3 abnormal pinna reflex 0.76240829075488 0.855045366660399 0.448372726254384 0.428571428571429 14.3 14 3 abnormal antigen presentation 0.76240829075488 0.855045366660399 0.448372726254384 0.428571428571429 14.3 14 3 abnormal endplate potential 0.76240829075488 0.855045366660399 0.448372726254384 0.428571428571429 14.3 14 3 abnormal uterus development 0.76240829075488 0.855045366660399 0.448372726254384 0.428571428571429 14.3 14 3 abnormal hair cuticle 0.76240829075488 0.855045366660399 0.448372726254384 0.428571428571429 14.3 14 3 enlarged stomach 0.76240829075488 0.855045366660399 0.448372726254384 0.428571428571429 14.3 14 3 abnormal positive T cell selection 0.76240829075488 0.855045366660399 0.448372726254384 0.428571428571429 14.3 14 3 abnormal renal reabsorbtion 0.76240829075488 0.855045366660399 0.448372726254384 0.428571428571429 14.3 14 3 decreased liver glycogen level 0.793213937477481 0.886862795645736 0.440506538074482 0.421052631578947 14.3 14 3 decreased digestive secretion 0.783629054408791 0.877262499028743 0.435917928302873 0.416666666666667 14.3 14 3 ear inflammation 0.783629054408791 0.877262499028743 0.435917928302873 0.416666666666667 14.3 14 3 increased fear-related response 0.783629054408791 0.877262499028743 0.435917928302873 0.416666666666667 14.3 14 3 abnormal anogenital distance 0.783629054408791 0.877262499028743 0.435917928302873 0.416666666666667 14.3 14 3 decreased renal glomerular filtration rate 0.783629054408791 0.877262499028743 0.435917928302873 0.416666666666667 14.3 14 3 decreased oligodendrocyte number 0.783629054408791 0.877262499028743 0.435917928302873 0.416666666666667 14.3 14 3 increased circulating total protein level 0.818470148796221 0.908295558835869 0.435917928302873 0.416666666666667 14.3 14 3 abnormal urinary bladder morphology 0.80939779336151 0.898427938860667 0.430789482087545 0.411764705882353 14.3 14 3 increased urine calcium level 0.845548750782902 0.935632792514444 0.418481211170758 0.4 14.3 14 3 abnormal epididymis epithelium morphology 0.877497062111576 0.952242682771191 0.392326135472586 0.375 14.3 14 3 decreased airway responsiveness 0.918275816098444 0.992056934872912 0.380437464700689 0.363636363636364 14.3 14 3 decreased acute inflammation 0.932663373780105 0.998278890825306 0.376633090053682 0.36 14.3 14 3 increased B-1 B cell number 0.895676734098981 0.969326028310296 0.37364393854532 0.357142857142857 14.3 14 3 altered righting response 0.92974252197591 0.997432893423627 0.348734342642299 0.333333333333333 14.3 14 3 decreased circulating progesterone level 0.976274938813736 1 0.336279544690788 0.321428571428571 14.3 14 3 abnormal circulating cytokine level 0.973795731157161 1 0.313860908378069 0.3 14.3 14 3 delayed limb development 0.000386835805936335 0.0110603915777774 2.70389780543728 1 14.2 14 2 skin hyperplasia 0.00143337160821002 0.0274270144263263 2.70389780543727 1 14.2 14 2 improved righting response 0.00143337160821002 0.0274270144263263 2.70389780543727 1 14.2 14 2 aorta hypoplasia 0.00143337160821002 0.0274270144263263 2.70389780543727 1 14.2 14 2 impaired branching involved in terminal bronchiole morphogenesis 0.00143337160821002 0.0274270144263263 2.70389780543727 1 14.2 14 2 decreased transitional stage T1 B cell number 0.000192712203039978 0.00626629549100583 2.40346471594424 0.888888888888889 14.2 14 2 ureter obstruction 0.00666605061957846 0.0795290211808221 2.25324817119773 0.833333333333333 14.2 14 2 absent parietal bone 0.00666605061957846 0.0795290211808221 2.25324817119773 0.833333333333333 14.2 14 2 delayed chorioallantoic fusion 0.00666605061957846 0.0795290211808221 2.25324817119773 0.833333333333333 14.2 14 2 thymus cortex atrophy 0.00666605061957846 0.0795290211808221 2.25324817119773 0.833333333333333 14.2 14 2 abnormal embryonic erythrocyte morphology 0.000733371472216834 0.0173739194013274 2.16311824434982 0.8 14.2 14 2 abnormal inferior vena cava valve morphology 0.000733371472216834 0.0173739194013274 2.16311824434982 0.8 14.2 14 2 decreased cochlear hair cell number 0.00219625887197934 0.0359420654213724 2.10303162645121 0.777777777777778 14.2 14 2 abnormal fertilization 8.67383116038511e-05 0.00324453458818917 2.02792335407796 0.75 14.2 14 2 abnormal NK cell morphology 0.00641220243803076 0.0778066027541537 2.02792335407796 0.75 14.2 14 2 abnormal cerebellum deep nucleus morphology 0.00641220243803076 0.0778066027541537 2.02792335407796 0.75 14.2 14 2 anomalous pulmonary venous connection 0.00641220243803076 0.0778066027541537 2.02792335407796 0.75 14.2 14 2 increased aorta wall thickness 0.00641220243803076 0.0778066027541537 2.02792335407796 0.75 14.2 14 2 abnormal proximal-distal axis patterning 0.00204928284437646 0.0342714639236127 1.96647113122711 0.727272727272727 14.2 14 2 pharyngeal arch hypoplasia 0.00204928284437646 0.0342714639236127 1.96647113122711 0.727272727272727 14.2 14 2 mammary gland hyperplasia 0.0181274041519973 0.161410754014792 1.93135557531234 0.714285714285714 14.2 14 2 limp posture 0.0181274041519973 0.161410754014792 1.93135557531234 0.714285714285714 14.2 14 2 decreased mortality induced by ionizing radiation 0.0181274041519973 0.161410754014792 1.93135557531234 0.714285714285714 14.2 14 2 abnormal central pattern generator function 0.0181274041519973 0.161410754014792 1.93135557531234 0.714285714285714 14.2 14 2 abnormal cochlear nerve compound action potential 0.0181274041519973 0.161410754014792 1.93135557531234 0.714285714285714 14.2 14 2 absent popliteal lymph nodes 0.0181274041519973 0.161410754014792 1.93135557531234 0.714285714285714 14.2 14 2 abnormal sperm annulus morphology 0.0181274041519973 0.161410754014792 1.93135557531234 0.714285714285714 14.2 14 2 increased oligodendrocyte number 0.0181274041519973 0.161410754014792 1.93135557531234 0.714285714285714 14.2 14 2 abnormal conotruncal ridge morphology 0.0181274041519973 0.161410754014792 1.93135557531234 0.714285714285714 14.2 14 2 embryonic lethality at implantation, incomplete penetrance 0.0181274041519973 0.161410754014792 1.93135557531234 0.714285714285714 14.2 14 2 abnormal sperm mitochondrial sheath morphology 7.44444278577901e-05 0.00291622857159454 1.89272846380609 0.7 14.2 14 2 increased skin tumor incidence 7.44444278577901e-05 0.00291622857159454 1.89272846380609 0.7 14.2 14 2 absent pharyngeal arches 0.00560966280475853 0.0704749304385699 1.89272846380609 0.7 14.2 14 2 vascular smooth muscle hyperplasia 0.00560966280475853 0.0704749304385699 1.89272846380609 0.7 14.2 14 2 thin ventricle myocardium compact layer 0.00560966280475853 0.0704749304385699 1.89272846380609 0.7 14.2 14 2 abnormal meiosis 0.00058843613610213 0.0147852008944853 1.85892974123813 0.6875 14.2 14 2 darkened coat color 0.000502134058587757 0.0135033348187789 1.80259853695818 0.666666666666667 14.2 14 2 abnormal pregnancy 0.000502134058587757 0.0135033348187789 1.80259853695818 0.666666666666667 14.2 14 2 interstitial pneumonia 0.0046915628798465 0.0625751349255666 1.80259853695818 0.666666666666667 14.2 14 2 abnormal vascular endothelial cell development 0.0046915628798465 0.0625751349255666 1.80259853695818 0.666666666666667 14.2 14 2 increased pheochromocytoma incidence 0.0148440895701336 0.143118886843827 1.80259853695818 0.666666666666667 14.2 14 2 abnormal NMDA-mediated synaptic currents 0.0148440895701336 0.143118886843827 1.80259853695818 0.666666666666667 14.2 14 2 decreased fear-related response 0.0148440895701336 0.143118886843827 1.80259853695818 0.666666666666667 14.2 14 2 increased neuronal precursor cell number 0.0148440895701336 0.143118886843827 1.80259853695818 0.666666666666667 14.2 14 2 liver hyperplasia 0.0148440895701336 0.143118886843827 1.80259853695818 0.666666666666667 14.2 14 2 abnormal liver vasculature morphology 0.0148440895701336 0.143118886843827 1.80259853695818 0.666666666666667 14.2 14 2 shortened ST segment 0.0148440895701336 0.143118886843827 1.80259853695818 0.666666666666667 14.2 14 2 abnormal infrahyoid muscle connection 0.0148440895701336 0.143118886843827 1.80259853695818 0.666666666666667 14.2 14 2 embryonic lethality between implantation and placentation, complete penetrance 6.76031767408401e-08 8.21244917847651e-06 1.7634116122417 0.652173913043478 14.2 14 2 hypotension 0.000141299981428625 0.0048817181083848 1.7634116122417 0.652173913043478 14.2 14 2 abnormal interatrial septum morphology 0.00126006927813523 0.0248763676933444 1.74958093293 0.647058823529412 14.2 14 2 abnormal cranial suture morphology 0.00126006927813523 0.0248763676933444 1.74958093293 0.647058823529412 14.2 14 2 abnormal myocardial trabeculae morphology 1.64827151326306e-07 1.70968497269619e-05 1.74251191905958 0.644444444444444 14.2 14 2 increased hemangioma incidence 0.00382807523863031 0.0547260756097293 1.73822001778111 0.642857142857143 14.2 14 2 lysosomal protein accumulation 0.00382807523863031 0.0547260756097293 1.73822001778111 0.642857142857143 14.2 14 2 testis degeneration 0.00382807523863031 0.0547260756097293 1.73822001778111 0.642857142857143 14.2 14 2 abnormal sperm midpiece morphology 0.00034636161693583 0.0100768949956477 1.72066223982372 0.636363636363636 14.2 14 2 dilated renal glomerular capsule 0.0118403277354271 0.122976264057933 1.72066223982372 0.636363636363636 14.2 14 2 abnormal spinal cord ventral horn morphology 0.0118403277354271 0.122976264057933 1.72066223982372 0.636363636363636 14.2 14 2 increased number of Howell-Jolly bodies 0.0118403277354271 0.122976264057933 1.72066223982372 0.636363636363636 14.2 14 2 abnormal pulmonary alveolar sac morphology 0.0118403277354271 0.122976264057933 1.72066223982372 0.636363636363636 14.2 14 2 decreased embryonic cilium length 0.0118403277354271 0.122976264057933 1.72066223982372 0.636363636363636 14.2 14 2 absent mandible 0.00307764113993408 0.0460648387847768 1.6899361283983 0.625 14.2 14 2 decreased liver cholesterol level 0.00307764113993408 0.0460648387847768 1.6899361283983 0.625 14.2 14 2 enlarged pituitary gland 0.0376527403419416 0.247780930160264 1.6899361283983 0.625 14.2 14 2 abnormal vagus ganglion morphology 0.0376527403419416 0.247780930160264 1.6899361283983 0.625 14.2 14 2 increased sensitivity to skin irradiation 0.0376527403419416 0.247780930160264 1.6899361283983 0.625 14.2 14 2 dermal cysts 0.0376527403419416 0.247780930160264 1.6899361283983 0.625 14.2 14 2 short ureter 0.0376527403419416 0.247780930160264 1.6899361283983 0.625 14.2 14 2 decreased aerobic running capacity 0.0376527403419416 0.247780930160264 1.6899361283983 0.625 14.2 14 2 colon polyps 0.0376527403419416 0.247780930160264 1.6899361283983 0.625 14.2 14 2 increased cardiac output 0.0376527403419416 0.247780930160264 1.6899361283983 0.625 14.2 14 2 abnormal eyelid aperture 0.0376527403419416 0.247780930160264 1.6899361283983 0.625 14.2 14 2 elevated level of mitotic sister chromatid exchange 0.0376527403419416 0.247780930160264 1.6899361283983 0.625 14.2 14 2 absent interparietal bone 0.0376527403419416 0.247780930160264 1.6899361283983 0.625 14.2 14 2 abnormal kidney epithelium morphology 0.0376527403419416 0.247780930160264 1.6899361283983 0.625 14.2 14 2 abnormal somite size 0.0376527403419416 0.247780930160264 1.6899361283983 0.625 14.2 14 2 ocular hypertension 0.0376527403419416 0.247780930160264 1.6899361283983 0.625 14.2 14 2 decreased susceptibility to autoimmune disorder 0.0376527403419416 0.247780930160264 1.6899361283983 0.625 14.2 14 2 abnormal frontonasal prominence morphology 0.0376527403419416 0.247780930160264 1.6899361283983 0.625 14.2 14 2 decreased hippocampus pyramidal cell number 0.0376527403419416 0.247780930160264 1.6899361283983 0.625 14.2 14 2 increased caudal vertebrae number 0.0376527403419416 0.247780930160264 1.6899361283983 0.625 14.2 14 2 abnormal brain ependyma morphology 0.0376527403419416 0.247780930160264 1.6899361283983 0.625 14.2 14 2 abnormal hepatic vein morphology 0.0376527403419416 0.247780930160264 1.6899361283983 0.625 14.2 14 2 abnormal visual evoked potential 0.0376527403419416 0.247780930160264 1.6899361283983 0.625 14.2 14 2 lung situs inversus 0.0376527403419416 0.247780930160264 1.6899361283983 0.625 14.2 14 2 abnormal anterior commissure pars posterior morphology 0.0376527403419416 0.247780930160264 1.6899361283983 0.625 14.2 14 2 abnormal maxillary prominence morphology 0.0376527403419416 0.247780930160264 1.6899361283983 0.625 14.2 14 2 abnormal heart echocardiography feature 0.0376527403419416 0.247780930160264 1.6899361283983 0.625 14.2 14 2 prolonged PQ interval 0.0376527403419416 0.247780930160264 1.6899361283983 0.625 14.2 14 2 increased testis apoptosis 0.0376527403419416 0.247780930160264 1.6899361283983 0.625 14.2 14 2 decreased vascular endothelial cell proliferation 0.0376527403419416 0.247780930160264 1.6899361283983 0.625 14.2 14 2 abnormal vocalization 7.76767105099661e-06 0.000424661137128661 1.68080133851506 0.621621621621622 14.2 14 2 abnormal embryonic erythropoiesis 7.89438238116272e-05 0.00300526118501361 1.67828139647831 0.620689655172414 14.2 14 2 liver hypoplasia 1.85033732630742e-07 1.8786588159958e-05 1.66393711103832 0.615384615384615 14.2 14 2 absent common myeloid progenitor cells 0.00932181737087791 0.104497455499628 1.66393711103832 0.615384615384615 14.2 14 2 absent myocardial trabeculae 0.00932181737087791 0.104497455499628 1.66393711103832 0.615384615384615 14.2 14 2 muscle fatigue 0.00932181737087791 0.104497455499628 1.66393711103832 0.615384615384615 14.2 14 2 increased gastrointestinal tumor incidence 0.00245111033742413 0.0394636696721198 1.65238199221167 0.611111111111111 14.2 14 2 lymphoid hyperplasia 0.00018420733282538 0.00615054685104875 1.64165223901549 0.607142857142857 14.2 14 2 small liver 7.20266336650862e-10 1.37820193263002e-07 1.62927175455836 0.602564102564103 14.2 14 2 abnormal primitive streak morphology 0.000530425680512108 0.0139622632833214 1.62233868326236 0.6 14.2 14 2 increased mammary adenocarcinoma incidence 0.0019399282748537 0.0336888157810791 1.62233868326236 0.6 14.2 14 2 decreased myocardial infarction size 0.0019399282748537 0.0336888157810791 1.62233868326236 0.6 14.2 14 2 decreased muscle cell glucose uptake 0.0019399282748537 0.0336888157810791 1.62233868326236 0.6 14.2 14 2 abnormal trophectoderm morphology 0.00728735607776708 0.0861154310852523 1.62233868326236 0.6 14.2 14 2 heterochrony 0.00728735607776708 0.0861154310852523 1.62233868326236 0.6 14.2 14 2 retarded hair growth 0.0286957297181962 0.212758949848027 1.62233868326236 0.6 14.2 14 2 abnormal mammary gland physiology 0.0286957297181962 0.212758949848027 1.62233868326236 0.6 14.2 14 2 abnormal PNS synaptic transmission 0.0286957297181962 0.212758949848027 1.62233868326236 0.6 14.2 14 2 abnormal gas homeostasis 0.0286957297181962 0.212758949848027 1.62233868326236 0.6 14.2 14 2 abnormal respiratory conducting tube morphology 0.0286957297181962 0.212758949848027 1.62233868326236 0.6 14.2 14 2 osteosclerosis 0.0286957297181962 0.212758949848027 1.62233868326236 0.6 14.2 14 2 abnormal sperm principal piece morphology 0.0286957297181962 0.212758949848027 1.62233868326236 0.6 14.2 14 2 decreased transitional stage T2 B cell number 0.0286957297181962 0.212758949848027 1.62233868326236 0.6 14.2 14 2 acanthocytosis 0.0286957297181962 0.212758949848027 1.62233868326236 0.6 14.2 14 2 abnormal heart and great artery attachment 0.0286957297181962 0.212758949848027 1.62233868326236 0.6 14.2 14 2 lethality during fetal growth through weaning, complete penetrance 0.0286957297181962 0.212758949848027 1.62233868326236 0.6 14.2 14 2 abnormal trigeminal nerve morphology 0.000421141921058426 0.0119724631843753 1.6023098106295 0.592592592592593 14.2 14 2 increased circulating creatine kinase level 0.001528760649148 0.0281951195231278 1.59775779412203 0.590909090909091 14.2 14 2 increased mammary gland tumor incidence 0.001528760649148 0.0281951195231278 1.59775779412203 0.590909090909091 14.2 14 2 increased adenoma incidence 0.001528760649148 0.0281951195231278 1.59775779412203 0.590909090909091 14.2 14 2 embryonic lethality before implantation, incomplete penetrance 0.001528760649148 0.0281951195231278 1.59775779412203 0.590909090909091 14.2 14 2 enlarged liver sinusoidal spaces 9.36853863408068e-05 0.00342709409592289 1.59052812084546 0.588235294117647 14.2 14 2 abnormal involuntary movement 0.00567417237107528 0.070927154638441 1.59052812084546 0.588235294117647 14.2 14 2 abnormal embryonic-extraembryonic boundary morphology 0.00567417237107528 0.070927154638441 1.59052812084546 0.588235294117647 14.2 14 2 abnormal spermiogenesis 4.04581444627179e-07 3.47033221900037e-05 1.5850435411184 0.586206896551724 14.2 14 2 increased mortality induced by gamma-irradiation 0.000333330637261531 0.00987095190700069 1.5850435411184 0.586206896551724 14.2 14 2 abnormal truncus arteriosus septation 0.00120110078031699 0.024027107373418 1.57727371983841 0.583333333333333 14.2 14 2 abnormal superior cervical ganglion morphology 0.02184859853324 0.173637025084455 1.57727371983841 0.583333333333333 14.2 14 2 myocarditis 0.02184859853324 0.173637025084455 1.57727371983841 0.583333333333333 14.2 14 2 abnormal cochlear outer hair cell physiology 0.02184859853324 0.173637025084455 1.57727371983841 0.583333333333333 14.2 14 2 abnormal aorta elastic tissue morphology 0.02184859853324 0.173637025084455 1.57727371983841 0.583333333333333 14.2 14 2 decreased mammary gland epithelial cell proliferation 0.02184859853324 0.173637025084455 1.57727371983841 0.583333333333333 14.2 14 2 embryonic lethality between implantation and placentation, incomplete penetrance 0.02184859853324 0.173637025084455 1.57727371983841 0.583333333333333 14.2 14 2 abnormal vitelline vein connection 0.02184859853324 0.173637025084455 1.57727371983841 0.583333333333333 14.2 14 2 abnormal triglyceride level 0.00440791850495252 0.0600805330469556 1.56541451893737 0.578947368421053 14.2 14 2 increased liver adenoma incidence 0.00440791850495252 0.0600805330469556 1.56541451893737 0.578947368421053 14.2 14 2 eyelids fail to open 0.00440791850495252 0.0600805330469556 1.56541451893737 0.578947368421053 14.2 14 2 embryonic lethality between implantation and somite formation, incomplete penetrance 0.00440791850495252 0.0600805330469556 1.56541451893737 0.578947368421053 14.2 14 2 heart inflammation 0.000941628732071395 0.0203678388785008 1.55994104159843 0.576923076923077 14.2 14 2 decreased brown adipose tissue amount 0.000207411376306025 0.00661456152001587 1.55678964555479 0.575757575757576 14.2 14 2 increased muscle cell glucose uptake 0.00341973889208301 0.0497462017196286 1.54508446024987 0.571428571428571 14.2 14 2 abnormal dermal layer morphology 0.000163207346882936 0.00552351395062996 1.54508446024987 0.571428571428571 14.2 14 2 subcutaneous edema 0.000737054705369155 0.017378422555505 1.54508446024987 0.571428571428571 14.2 14 2 abnormal blood flow velocity 0.0166468068805414 0.154510940728906 1.54508446024987 0.571428571428571 14.2 14 2 extended life span 0.0166468068805414 0.154510940728906 1.54508446024987 0.571428571428571 14.2 14 2 increased lactate dehydrogenase level 0.0166468068805414 0.154510940728906 1.54508446024987 0.571428571428571 14.2 14 2 absent otoliths 0.0166468068805414 0.154510940728906 1.54508446024987 0.571428571428571 14.2 14 2 failure of zygotic cell division 0.0166468068805414 0.154510940728906 1.54508446024987 0.571428571428571 14.2 14 2 abnormal cranial nerve morphology 0.00265119919477594 0.0408350340371835 1.52829006394281 0.565217391304348 14.2 14 2 abnormal circulating insulin level 0.00265119919477594 0.0408350340371835 1.52829006394281 0.565217391304348 14.2 14 2 abnormal cardiovascular development 0.00265119919477594 0.0408350340371835 1.52829006394281 0.565217391304348 14.2 14 2 decreased effector memory CD8-positive, alpha-beta T cell number 0.00265119919477594 0.0408350340371835 1.52829006394281 0.565217391304348 14.2 14 2 abnormal embryo turning 4.13186524961852e-06 0.000253778143417927 1.52401512670101 0.563636363636364 14.2 14 2 pancreatic islet hyperplasia 0.000450178605514131 0.01244243645796 1.52094251555847 0.5625 14.2 14 2 loose skin 0.0126998467121238 0.127382535066162 1.52094251555847 0.5625 14.2 14 2 abnormal pulmonary alveolus wall morphology 0.0126998467121238 0.127382535066162 1.52094251555847 0.5625 14.2 14 2 abnormal cell differentiation 7.90117224177479e-05 0.00300526118501361 1.51682072012335 0.560975609756098 14.2 14 2 increased grip strength 4.79134910061604e-09 7.01087111046024e-07 1.51537129755276 0.56043956043956 14.2 14 2 spontaneous skin ulceration 0.00205468727097775 0.0342714639236127 1.51418277104487 0.56 14.2 14 2 abnormal egg cylinder morphology 0.00205468727097775 0.0342714639236127 1.51418277104487 0.56 14.2 14 2 abnormal preimplantation embryo development 0.00205468727097775 0.0342714639236127 1.51418277104487 0.56 14.2 14 2 abnormal placenta vasculature 1.1123756223728e-05 0.000584207226802437 1.50794300687848 0.557692307692308 14.2 14 2 abnormal mitral valve morphology 0.00970299991313925 0.106093240808501 1.50216544746515 0.555555555555556 14.2 14 2 abnormal phrenic nerve morphology 0.00970299991313925 0.106093240808501 1.50216544746515 0.555555555555556 14.2 14 2 blepharoptosis 0.00970299991313925 0.106093240808501 1.50216544746515 0.555555555555556 14.2 14 2 absent inner cell mass 0.00970299991313925 0.106093240808501 1.50216544746515 0.555555555555556 14.2 14 2 abnormal sperm axoneme morphology 0.00970299991313925 0.106093240808501 1.50216544746515 0.555555555555556 14.2 14 2 decreased tumor latency 0.00970299991313925 0.106093240808501 1.50216544746515 0.555555555555556 14.2 14 2 crypts of Lieberkuhn abscesses 0.0661635538067016 0.3367822805716 1.50216544746515 0.555555555555556 14.2 14 2 renal tubular acidosis 0.0661635538067016 0.3367822805716 1.50216544746515 0.555555555555556 14.2 14 2 abnormal sympathetic neuron morphology 0.0661635538067016 0.3367822805716 1.50216544746515 0.555555555555556 14.2 14 2 abnormal kindling response 0.0661635538067016 0.3367822805716 1.50216544746515 0.555555555555556 14.2 14 2 abnormal ion homeostasis 0.0661635538067016 0.3367822805716 1.50216544746515 0.555555555555556 14.2 14 2 abnormal abdominal wall morphology 0.0661635538067016 0.3367822805716 1.50216544746515 0.555555555555556 14.2 14 2 abnormal artery development 0.0661635538067016 0.3367822805716 1.50216544746515 0.555555555555556 14.2 14 2 premature neuronal precursor differentiation 0.0661635538067016 0.3367822805716 1.50216544746515 0.555555555555556 14.2 14 2 decreased cellular sensitivity to ionizing radiation 0.0661635538067016 0.3367822805716 1.50216544746515 0.555555555555556 14.2 14 2 abnormal hair cell mechanoelectric transduction 0.0661635538067016 0.3367822805716 1.50216544746515 0.555555555555556 14.2 14 2 abnormal gallbladder physiology 0.0661635538067016 0.3367822805716 1.50216544746515 0.555555555555556 14.2 14 2 abnormal intervertebral disk development 0.0661635538067016 0.3367822805716 1.50216544746515 0.555555555555556 14.2 14 2 absent cervical lymph nodes 0.0661635538067016 0.3367822805716 1.50216544746515 0.555555555555556 14.2 14 2 multiflagellated sperm 0.0661635538067016 0.3367822805716 1.50216544746515 0.555555555555556 14.2 14 2 increased core body temperature 0.0661635538067016 0.3367822805716 1.50216544746515 0.555555555555556 14.2 14 2 abnormal coronary sinus connection 0.0661635538067016 0.3367822805716 1.50216544746515 0.555555555555556 14.2 14 2 increased cardiac muscle glycogen level 0.0661635538067016 0.3367822805716 1.50216544746515 0.555555555555556 14.2 14 2 decreased fatty acid oxidation 0.0661635538067016 0.3367822805716 1.50216544746515 0.555555555555556 14.2 14 2 adipose tissue inflammation 0.0661635538067016 0.3367822805716 1.50216544746515 0.555555555555556 14.2 14 2 azoospermia 4.07411820478363e-14 1.55913369759989e-11 1.49649689860679 0.553459119496855 14.2 14 2 abnormal erythropoiesis 9.22666731465571e-10 1.58285068587628e-07 1.49358164490821 0.552380952380952 14.2 14 2 decreased circulating VLDL cholesterol level 0.00742435100840664 0.0867045687014626 1.4871437929905 0.55 14.2 14 2 absent ductus venosus valve 0.00742435100840664 0.0867045687014626 1.4871437929905 0.55 14.2 14 2 abnormal postnatal growth/weight/body size 0.000956432723806693 0.020509710348872 1.48278266749786 0.548387096774194 14.2 14 2 abnormal mitochondrial ATP synthesis coupled electron transport 0.000956432723806693 0.020509710348872 1.48278266749786 0.548387096774194 14.2 14 2 abnormal vascular development 2.04111904410183e-06 0.00013722388168117 1.47485334842033 0.545454545454545 14.2 14 2 abnormal locomotor coordination 0.000741499280563851 0.0174007496264394 1.47485334842033 0.545454545454545 14.2 14 2 premature suture closure 0.0489222120975191 0.290948891067549 1.47485334842033 0.545454545454545 14.2 14 2 delayed hepatic development 0.0489222120975191 0.290948891067549 1.47485334842033 0.545454545454545 14.2 14 2 abnormal sebaceous gland morphology 0.0489222120975191 0.290948891067549 1.47485334842033 0.545454545454545 14.2 14 2 abnormal eye distance/ position 0.0489222120975191 0.290948891067549 1.47485334842033 0.545454545454545 14.2 14 2 abnormal Bruch membrane morphology 0.0489222120975191 0.290948891067549 1.47485334842033 0.545454545454545 14.2 14 2 abnormal palatal shelf elevation 0.0489222120975191 0.290948891067549 1.47485334842033 0.545454545454545 14.2 14 2 thin hypoglossal nerve 0.0489222120975191 0.290948891067549 1.47485334842033 0.545454545454545 14.2 14 2 reduced sympathetic cervical ganglion size 0.0489222120975191 0.290948891067549 1.47485334842033 0.545454545454545 14.2 14 2 incomplete embryo turning 1.11644688857136e-05 0.000584207226802437 1.47054091172904 0.543859649122807 14.2 14 2 abnormal allantois morphology 7.91335106003583e-05 0.00300526118501361 1.46950967686808 0.543478260869565 14.2 14 2 abnormal myelin sheath morphology 7.91335106003583e-05 0.00300526118501361 1.46950967686808 0.543478260869565 14.2 14 2 embryonic lethality between implantation and somite formation, complete penetrance 1.39449054849392e-19 8.67198809844659e-17 1.46783023723738 0.542857142857143 14.2 14 2 abnormal liver development 0.000575019425107897 0.0145955185709785 1.46783023723738 0.542857142857143 14.2 14 2 increased carcinoma incidence 0.000575019425107897 0.0145955185709785 1.46783023723738 0.542857142857143 14.2 14 2 abnormal vasodilation 0.00436495186640924 0.0600805330469556 1.46461131127852 0.541666666666667 14.2 14 2 abnormal primitive streak formation 0.00436495186640924 0.0600805330469556 1.46461131127852 0.541666666666667 14.2 14 2 increased body temperature 0.00436495186640924 0.0600805330469556 1.46461131127852 0.541666666666667 14.2 14 2 abnormal female meiosis 3.75175243539486e-05 0.00163727792684995 1.45594497215853 0.538461538461538 14.2 14 2 ventricular hypoplasia 0.0033532555663685 0.0492107564680922 1.45594497215853 0.538461538461538 14.2 14 2 absent teeth 0.0364631765559958 0.247780930160264 1.45594497215853 0.538461538461538 14.2 14 2 increased foot pad pigmentation 0.0364631765559958 0.247780930160264 1.45594497215853 0.538461538461538 14.2 14 2 abnormal grip strength 0.0364631765559958 0.247780930160264 1.45594497215853 0.538461538461538 14.2 14 2 increased pituitary adenoma incidence 0.0364631765559958 0.247780930160264 1.45594497215853 0.538461538461538 14.2 14 2 abnormal exocrine pancreas morphology 0.0364631765559958 0.247780930160264 1.45594497215853 0.538461538461538 14.2 14 2 abnormal vertebral arch development 0.0364631765559958 0.247780930160264 1.45594497215853 0.538461538461538 14.2 14 2 empty decidua capsularis 0.0364631765559958 0.247780930160264 1.45594497215853 0.538461538461538 14.2 14 2 increased embryonic tissue cell apoptosis 4.73021966361216e-07 3.79561981072105e-05 1.45594497215853 0.538461538461538 14.2 14 2 increased hepatocyte apoptosis 0.000346105992096736 0.0100768949956477 1.45594497215853 0.538461538461538 14.2 14 2 lethality throughout fetal growth and development, complete penetrance 6.08252290663227e-15 2.52171262170796e-12 1.45156619028738 0.536842105263158 14.2 14 2 small superior cervical ganglion 0.0025789863309935 0.04045276511085 1.44851668148425 0.535714285714286 14.2 14 2 straub tail 0.0025789863309935 0.04045276511085 1.44851668148425 0.535714285714286 14.2 14 2 increased triglyceride level 0.0025789863309935 0.04045276511085 1.44851668148425 0.535714285714286 14.2 14 2 abnormal heart tube morphology 0.00198557895636228 0.0341808142141949 1.44207882956655 0.533333333333333 14.2 14 2 decreased hepatocyte number 0.027343322083712 0.207684011246515 1.44207882956655 0.533333333333333 14.2 14 2 abnormal enteric neuron morphology 0.027343322083712 0.207684011246515 1.44207882956655 0.533333333333333 14.2 14 2 abnormal lymph node B cell domain morphology 0.027343322083712 0.207684011246515 1.44207882956655 0.533333333333333 14.2 14 2 delayed intramembranous bone ossification 0.027343322083712 0.207684011246515 1.44207882956655 0.533333333333333 14.2 14 2 decreased thymocyte apoptosis 0.027343322083712 0.207684011246515 1.44207882956655 0.533333333333333 14.2 14 2 abnormal aorta wall morphology 0.027343322083712 0.207684011246515 1.44207882956655 0.533333333333333 14.2 14 2 decreased brown adipose tissue mass 0.027343322083712 0.207684011246515 1.44207882956655 0.533333333333333 14.2 14 2 thin ventricular wall 1.09239325052031e-07 1.23027689871353e-05 1.44207882956655 0.533333333333333 14.2 14 2 abnormal ectoderm development 0.000161992566530751 0.0055199521814417 1.44207882956655 0.533333333333333 14.2 14 2 abnormal diaphragm morphology 0.00153018739120493 0.0281951195231278 1.43644570913855 0.53125 14.2 14 2 abnormal embryonic hematopoiesis 0.00153018739120493 0.0281951195231278 1.43644570913855 0.53125 14.2 14 2 increased fibroblast apoptosis 0.00153018739120493 0.0281951195231278 1.43644570913855 0.53125 14.2 14 2 abnormal oocyte morphology 0.00118028863715348 0.0238696584139779 1.43147530876091 0.529411764705882 14.2 14 2 lung hemorrhage 0.00118028863715348 0.0238696584139779 1.43147530876091 0.529411764705882 14.2 14 2 abnormal brown adipose tissue morphology 0.00118028863715348 0.0238696584139779 1.43147530876091 0.529411764705882 14.2 14 2 abnormal bone marrow cavity morphology 0.0206037303458034 0.167606704806532 1.43147530876091 0.529411764705882 14.2 14 2 abnormal dorsal-ventral axis patterning 0.0206037303458034 0.167606704806532 1.43147530876091 0.529411764705882 14.2 14 2 increased brain size 0.0206037303458034 0.167606704806532 1.43147530876091 0.529411764705882 14.2 14 2 delayed heart development 0.0206037303458034 0.167606704806532 1.43147530876091 0.529411764705882 14.2 14 2 abnormal cell cytoskeleton morphology 0.0206037303458034 0.167606704806532 1.43147530876091 0.529411764705882 14.2 14 2 abnormal trophoblast giant cell morphology 0.000911145854047715 0.0199888621206286 1.4270571750919 0.527777777777778 14.2 14 2 decreased circulating total protein level 4.59719496796712e-05 0.00190592041380303 1.42569157013965 0.527272727272727 14.2 14 2 enlarged adrenal glands 0.0155864237000134 0.146306524353899 1.42310410812488 0.526315789473684 14.2 14 2 delayed sexual maturation 0.0155864237000134 0.146306524353899 1.42310410812488 0.526315789473684 14.2 14 2 abnormal digestive system development 0.0155864237000134 0.146306524353899 1.42310410812488 0.526315789473684 14.2 14 2 abnormal blastocyst morphology 0.0155864237000134 0.146306524353899 1.42310410812488 0.526315789473684 14.2 14 2 decreased liver regeneration 0.0155864237000134 0.146306524353899 1.42310410812488 0.526315789473684 14.2 14 2 decreased fertilization frequency 0.0155864237000134 0.146306524353899 1.42310410812488 0.526315789473684 14.2 14 2 right-sided stomach 0.0155864237000134 0.146306524353899 1.42310410812488 0.526315789473684 14.2 14 2 decreased circulating phosphate level 0.000544188473794864 0.014174542707484 1.41954634785457 0.525 14.2 14 2 abnormal male meiosis 2.16586981546726e-05 0.00102620974589996 1.41843819301628 0.524590163934426 14.2 14 2 abnormal anxiety-related response 0.0118294243363626 0.122976264057933 1.41632742189572 0.523809523809524 14.2 14 2 trunk curl 0.0118294243363626 0.122976264057933 1.41632742189572 0.523809523809524 14.2 14 2 liver degeneration 0.0118294243363626 0.122976264057933 1.41632742189572 0.523809523809524 14.2 14 2 abnormal bile salt homeostasis 0.0118294243363626 0.122976264057933 1.41632742189572 0.523809523809524 14.2 14 2 teratozoospermia 4.32194709640718e-07 3.58361446743762e-05 1.41340112556948 0.522727272727273 14.2 14 2 abnormal cell death 0.000252384263909362 0.00775068958610542 1.41072928979336 0.521739130434783 14.2 14 2 abnormal ulna morphology 0.00900278215323672 0.102257628338705 1.41072928979336 0.521739130434783 14.2 14 2 vertebral transformation 0.000195573709543717 0.00631804678558438 1.40828010699858 0.520833333333333 14.2 14 2 abnormal interventricular septum morphology 0.000151625046730122 0.00520230763780936 1.40602685882738 0.52 14.2 14 2 abnormal extraembryonic tissue morphology 7.67224436930156e-08 9.08795612792269e-06 1.40496650674682 0.519607843137255 14.2 14 2 abnormal apoptosis 9.12588607018518e-05 0.00338815546262472 1.40202108430081 0.518518518518518 14.2 14 2 increased brain weight 0.00524973683463252 0.067746173627598 1.40202108430081 0.518518518518518 14.2 14 2 abnormal eye muscle morphology 0.00524973683463252 0.067746173627598 1.40202108430081 0.518518518518518 14.2 14 2 decreased bone ossification 0.00524973683463252 0.067746173627598 1.40202108430081 0.518518518518518 14.2 14 2 decreased trophoblast giant cell number 0.00402010111478976 0.0566572324251531 1.39856783039859 0.517241379310345 14.2 14 2 abnormal eating behavior 4.27381982992972e-05 0.00180188590287291 1.39701386614259 0.516666666666667 14.2 14 2 absent mesoderm 4.27381982992972e-05 0.00180188590287291 1.39701386614259 0.516666666666667 14.2 14 2 increased erythrocyte cell number 4.27381982992972e-05 0.00180188590287291 1.39701386614259 0.516666666666667 14.2 14 2 decreased thymus weight 0.00308333493775491 0.0460648387847768 1.39556015764504 0.516129032258065 14.2 14 2 abnormal ovarian folliculogenesis 0.00236816850876108 0.0382520725035271 1.39291705128587 0.515151515151515 14.2 14 2 abnormal embryonic epiblast morphology 0.00182116192049585 0.0323587966620818 1.39057601422488 0.514285714285714 14.2 14 2 pulmonary hypoplasia 0.000384420497939643 0.0110548669205186 1.38071377298925 0.51063829787234 14.2 14 2 increased T cell derived lymphoma incidence 0.000297422535378926 0.00891371755126602 1.37953969665167 0.510204081632653 14.2 14 2 abnormal gluconeogenesis 0.000230252564077833 0.00725004117903304 1.37845770473273 0.509803921568627 14.2 14 2 seminiferous tubule degeneration 1.42017459166347e-05 0.000720955978931202 1.37046875070108 0.506849315068493 14.2 14 2 abnormal somite development 6.68955345629347e-06 0.000373938521854607 1.36906217996824 0.506329113924051 14.2 14 2 abnormal placenta labyrinth morphology 6.68955345629347e-06 0.000373938521854607 1.36906217996824 0.506329113924051 14.2 14 2 pale yolk sac 4.05466281742584e-06 0.000252149343958669 1.36823744371525 0.506024096385542 14.2 14 2 increased mean corpuscular hemoglobin 5.51484589541925e-07 4.28693098901731e-05 1.36560495224105 0.505050505050505 14.2 14 2 abnormal embryonic tissue morphology 1.45228837781885e-09 2.40837822654959e-07 1.36114583402965 0.503401360544218 14.2 14 2 arrest of spermatogenesis 5.99958512385646e-06 0.000351152188131599 1.35194890271864 0.5 14.2 14 2 axon degeneration 0.000265446069446824 0.00805240363108505 1.35194890271864 0.5 14.2 14 2 increased B cell derived lymphoma incidence 0.000443220024027734 0.0123185453605474 1.35194890271864 0.5 14.2 14 2 increased circulating chloride level 0.000443220024027734 0.0123185453605474 1.35194890271864 0.5 14.2 14 2 small heart 0.000573267286335569 0.0145955185709785 1.35194890271864 0.5 14.2 14 2 spina bifida 0.00124604474124763 0.0247962903508278 1.35194890271864 0.5 14.2 14 2 decreased neuron apoptosis 0.00210025920078048 0.0345986408075593 1.35194890271864 0.5 14.2 14 2 abnormal nervous system development 0.00355604838036867 0.0515782527473298 1.35194890271864 0.5 14.2 14 2 emphysema 0.00605462327321723 0.0753043769606393 1.35194890271864 0.5 14.2 14 2 increased leukemia incidence 0.0103822214565515 0.112042411597275 1.35194890271864 0.5 14.2 14 2 abnormal Mullerian duct morphology 0.0103822214565515 0.112042411597275 1.35194890271864 0.5 14.2 14 2 apnea 0.0136406124400641 0.134646918431189 1.35194890271864 0.5 14.2 14 2 increased hemangiosarcoma incidence 0.0136406124400641 0.134646918431189 1.35194890271864 0.5 14.2 14 2 abnormal glossopharyngeal nerve morphology 0.0759958256617982 0.351374751549671 1.35194890271864 0.5 14.2 14 2 impaired embryo implantation 0.0759958256617982 0.351374751549671 1.35194890271864 0.5 14.2 14 2 increased litter size 0.0759958256617982 0.351374751549671 1.35194890271864 0.5 14.2 14 2 abnormal tracheal ciliated epithelium morphology 0.0759958256617982 0.351374751549671 1.35194890271864 0.5 14.2 14 2 abnormal AMPA-mediated synaptic currents 0.0759958256617982 0.351374751549671 1.35194890271864 0.5 14.2 14 2 abnormal aorta elastic fiber morphology 0.0759958256617982 0.351374751549671 1.35194890271864 0.5 14.2 14 2 loss of dopaminergic neurons 0.0759958256617982 0.351374751549671 1.35194890271864 0.5 14.2 14 2 small intestinal inflammation 0.0759958256617982 0.351374751549671 1.35194890271864 0.5 14.2 14 2 impaired sperm capacitation 0.0759958256617982 0.351374751549671 1.35194890271864 0.5 14.2 14 2 delayed somite formation 0.0759958256617982 0.351374751549671 1.35194890271864 0.5 14.2 14 2 abnormal rostral-caudal body axis extension 0.0759958256617982 0.351374751549671 1.35194890271864 0.5 14.2 14 2 abnormal amacrine cell morphology 0.0759958256617982 0.351374751549671 1.35194890271864 0.5 14.2 14 2 abnormal somatic nervous system physiology 0.0759958256617982 0.351374751549671 1.35194890271864 0.5 14.2 14 2 decreased keratinocyte proliferation 0.0759958256617982 0.351374751549671 1.35194890271864 0.5 14.2 14 2 hydrometra 0.0759958256617982 0.351374751549671 1.35194890271864 0.5 14.2 14 2 abnormal colon goblet cell morphology 0.0759958256617982 0.351374751549671 1.35194890271864 0.5 14.2 14 2 pale liver 2.10442847523362e-05 0.0010066857369507 1.35194890271864 0.5 14.2 14 2 small seminiferous tubules 2.10442847523362e-05 0.0010066857369507 1.35194890271864 0.5 14.2 14 2 embryonic lethality between somite formation and embryo turning, complete penetrance 3.48327274609871e-05 0.00156119656863433 1.35194890271864 0.5 14.2 14 2 abnormal osteoclast physiology 7.43649740992113e-05 0.00291622857159454 1.35194890271864 0.5 14.2 14 2 prenatal lethality 9.5828351875013e-05 0.00345468152592891 1.35194890271864 0.5 14.2 14 2 muscular atrophy 0.000961137440538289 0.0205221406295193 1.35194890271864 0.5 14.2 14 2 abnormal uterus morphology 0.00273117798694401 0.0418080322616814 1.35194890271864 0.5 14.2 14 2 abnormal pharyngeal arch morphology 0.00273117798694401 0.0418080322616814 1.35194890271864 0.5 14.2 14 2 neonatal lethality 0.00463648248430486 0.0621738554162175 1.35194890271864 0.5 14.2 14 2 failure of blastocyst to hatch from the zona pellucida 0.00792048733827154 0.090584883926209 1.35194890271864 0.5 14.2 14 2 abnormal brainstem morphology 0.00792048733827154 0.090584883926209 1.35194890271864 0.5 14.2 14 2 prolonged QRS complex duration 0.00792048733827154 0.090584883926209 1.35194890271864 0.5 14.2 14 2 abnormal abdominal fat pad morphology 0.0179699358891203 0.161410754014792 1.35194890271864 0.5 14.2 14 2 increased body size 0.0179699358891203 0.161410754014792 1.35194890271864 0.5 14.2 14 2 abnormal tail movements 0.0179699358891203 0.161410754014792 1.35194890271864 0.5 14.2 14 2 abnormal oogenesis 0.0179699358891203 0.161410754014792 1.35194890271864 0.5 14.2 14 2 testis hypoplasia 0.0179699358891203 0.161410754014792 1.35194890271864 0.5 14.2 14 2 increased skin papilloma incidence 0.0179699358891203 0.161410754014792 1.35194890271864 0.5 14.2 14 2 abnormal vascular branching morphogenesis 0.0179699358891203 0.161410754014792 1.35194890271864 0.5 14.2 14 2 abnormal female reproductive system physiology 0.0179699358891203 0.161410754014792 1.35194890271864 0.5 14.2 14 2 anencephaly 0.0237484963916201 0.186648925036825 1.35194890271864 0.5 14.2 14 2 abnormal male reproductive system physiology 0.0237484963916201 0.186648925036825 1.35194890271864 0.5 14.2 14 2 abnormal physiological neovascularization 0.0237484963916201 0.186648925036825 1.35194890271864 0.5 14.2 14 2 abnormal postnatal subventricular zone morphology 0.0237484963916201 0.186648925036825 1.35194890271864 0.5 14.2 14 2 right pulmonary isomerism 0.0315044607784676 0.224214059969107 1.35194890271864 0.5 14.2 14 2 abnormal bile duct morphology 0.0315044607784676 0.224214059969107 1.35194890271864 0.5 14.2 14 2 abnormal white adipose tissue morphology 0.0315044607784676 0.224214059969107 1.35194890271864 0.5 14.2 14 2 long tibia 0.0315044607784676 0.224214059969107 1.35194890271864 0.5 14.2 14 2 abnormal eye anterior chamber morphology 0.0315044607784676 0.224214059969107 1.35194890271864 0.5 14.2 14 2 abnormal glycogen homeostasis 0.0315044607784676 0.224214059969107 1.35194890271864 0.5 14.2 14 2 decreased lactate dehydrogenase level 0.0315044607784676 0.224214059969107 1.35194890271864 0.5 14.2 14 2 decreased pulmonary respiratory rate 0.0315044607784676 0.224214059969107 1.35194890271864 0.5 14.2 14 2 primary atelectasis 0.0315044607784676 0.224214059969107 1.35194890271864 0.5 14.2 14 2 abnormal bone marrow cell number 0.0419867974553002 0.267457512599384 1.35194890271864 0.5 14.2 14 2 abnormal mouth morphology 0.0419867974553002 0.267457512599384 1.35194890271864 0.5 14.2 14 2 increased intestinal adenocarcinoma incidence 0.0419867974553002 0.267457512599384 1.35194890271864 0.5 14.2 14 2 abnormal epicardium morphology 0.0419867974553002 0.267457512599384 1.35194890271864 0.5 14.2 14 2 abnormal pulmonary elastic fiber morphology 0.0419867974553002 0.267457512599384 1.35194890271864 0.5 14.2 14 2 blepharitis 0.0419867974553002 0.267457512599384 1.35194890271864 0.5 14.2 14 2 kidney degeneration 0.0419867974553002 0.267457512599384 1.35194890271864 0.5 14.2 14 2 decreased adipocyte glucose uptake 0.0419867974553002 0.267457512599384 1.35194890271864 0.5 14.2 14 2 megacephaly 0.0562795462314501 0.320355540619524 1.35194890271864 0.5 14.2 14 2 abnormal fluid regulation 0.0562795462314501 0.320355540619524 1.35194890271864 0.5 14.2 14 2 abnormal imprinting 0.0562795462314501 0.320355540619524 1.35194890271864 0.5 14.2 14 2 vascular smooth muscle hypoplasia 0.0562795462314501 0.320355540619524 1.35194890271864 0.5 14.2 14 2 abnormal maternal decidual layer morphology 0.0562795462314501 0.320355540619524 1.35194890271864 0.5 14.2 14 2 abnormal viscerocranium morphology 0.0562795462314501 0.320355540619524 1.35194890271864 0.5 14.2 14 2 increased pulmonary respiratory rate 0.0562795462314501 0.320355540619524 1.35194890271864 0.5 14.2 14 2 increased stomach tumor incidence 0.0562795462314501 0.320355540619524 1.35194890271864 0.5 14.2 14 2 multiple persisting craniopharyngeal ducts 0.0562795462314501 0.320355540619524 1.35194890271864 0.5 14.2 14 2 increased cranium width 0.103631377895207 0.431075338652721 1.35194890271864 0.5 14.2 14 2 enlarged testis 0.103631377895207 0.431075338652721 1.35194890271864 0.5 14.2 14 2 abnormal prostate gland epithelium morphology 0.103631377895207 0.431075338652721 1.35194890271864 0.5 14.2 14 2 impaired basement membrane formation 0.103631377895207 0.431075338652721 1.35194890271864 0.5 14.2 14 2 acrania 0.103631377895207 0.431075338652721 1.35194890271864 0.5 14.2 14 2 aneurysm 0.103631377895207 0.431075338652721 1.35194890271864 0.5 14.2 14 2 absent CD4-positive, alpha beta T cells 0.103631377895207 0.431075338652721 1.35194890271864 0.5 14.2 14 2 increased atrioventricular cushion size 0.103631377895207 0.431075338652721 1.35194890271864 0.5 14.2 14 2 abnormal ear physiology 0.103631377895207 0.431075338652721 1.35194890271864 0.5 14.2 14 2 abnormal gonadal fat pad morphology 0.103631377895207 0.431075338652721 1.35194890271864 0.5 14.2 14 2 absent inguinal lymph nodes 0.103631377895207 0.431075338652721 1.35194890271864 0.5 14.2 14 2 absent axillary lymph nodes 0.103631377895207 0.431075338652721 1.35194890271864 0.5 14.2 14 2 abnormal spinal cord dorsal column morphology 0.103631377895207 0.431075338652721 1.35194890271864 0.5 14.2 14 2 increased circulating fructosamine level 0.103631377895207 0.431075338652721 1.35194890271864 0.5 14.2 14 2 increased T-helper 17 cell number 0.103631377895207 0.431075338652721 1.35194890271864 0.5 14.2 14 2 increased kidney iron level 0.103631377895207 0.431075338652721 1.35194890271864 0.5 14.2 14 2 common ventricle 0.103631377895207 0.431075338652721 1.35194890271864 0.5 14.2 14 2 abnormal left subclavian artery morphology 0.103631377895207 0.431075338652721 1.35194890271864 0.5 14.2 14 2 fusion of atlas and odontoid process 0.103631377895207 0.431075338652721 1.35194890271864 0.5 14.2 14 2 abnormal circadian temperature homeostasis 0.103631377895207 0.431075338652721 1.35194890271864 0.5 14.2 14 2 decreased macrophage apoptosis 0.103631377895207 0.431075338652721 1.35194890271864 0.5 14.2 14 2 decreased circulating lactate level 0.103631377895207 0.431075338652721 1.35194890271864 0.5 14.2 14 2 abnormal lung development 8.77535783763852e-06 0.000469434464970448 1.33604362151018 0.494117647058824 14.2 14 2 abnormal neural tube closure 1.12731444769918e-05 0.000584207226802437 1.33566036172203 0.493975903614458 14.2 14 2 decreased susceptibility to hepatic steatosis 0.000140136013965092 0.00487536132500931 1.33048939632628 0.492063492063492 14.2 14 2 embryonic lethality during organogenesis, complete penetrance 2.72032260115959e-29 6.76680247038447e-26 1.32780695802723 0.491071428571429 14.2 14 2 abnormal axon morphology 8.19317967210957e-07 6.08374162220076e-05 1.32691281192755 0.490740740740741 14.2 14 2 abnormal trophoblast layer morphology 0.000647996427825714 0.0158283548869897 1.32544010070455 0.490196078431373 14.2 14 2 abnormal dendritic spine morphology 0.000647996427825714 0.0158283548869897 1.32544010070455 0.490196078431373 14.2 14 2 increased circulating LDL cholesterol level 0.000838078247253945 0.0189780382485429 1.3243581087856 0.489795918367347 14.2 14 2 abnormal craniofacial development 0.000838078247253945 0.0189780382485429 1.3243581087856 0.489795918367347 14.2 14 2 decreased circulating creatinine level 0.000838078247253945 0.0189780382485429 1.3243581087856 0.489795918367347 14.2 14 2 increased circulating corticosterone level 0.00140491151907967 0.0274095482643975 1.32190559376933 0.488888888888889 14.2 14 2 abnormal homeostasis 0.00182119860610712 0.0323587966620818 1.32050823056239 0.488372093023256 14.2 14 2 anemia 1.08956590436131e-11 2.58123351152263e-09 1.31991219886275 0.488151658767773 14.2 14 2 abnormal mammary gland development 0.00236297946756894 0.0382520725035271 1.3189745392377 0.48780487804878 14.2 14 2 abnormal cholesterol homeostasis 0.00236297946756894 0.0382520725035271 1.3189745392377 0.48780487804878 14.2 14 2 decreased embryo size 1.83055076783314e-24 1.82139801399397e-21 1.31800876290143 0.48744769874477 14.2 14 2 abnormal heart looping 0.00306898906375549 0.0460648387847768 1.31728354623867 0.487179487179487 14.2 14 2 abnormal branching of the mammary ductal tree 0.00399031960743709 0.0563972728607941 1.3154097431857 0.486486486486487 14.2 14 2 increased erythroid progenitor cell number 0.00399031960743709 0.0563972728607941 1.3154097431857 0.486486486486487 14.2 14 2 hydrops fetalis 7.35250207253468e-05 0.00291622857159454 1.31439476653201 0.486111111111111 14.2 14 2 abnormal liver morphology 5.52426719536384e-10 1.14513455403896e-07 1.31418496688851 0.486033519553073 14.2 14 2 pallor 9.02624680102503e-10 1.58285068587628e-07 1.31332179121239 0.485714285714286 14.2 14 2 impaired fertilization 9.46017896883231e-05 0.00343535696130954 1.31332179121239 0.485714285714286 14.2 14 2 decreased circulating thyroxine level 0.00519455225913742 0.067746173627598 1.31332179121239 0.485714285714286 14.2 14 2 abnormal embryo development 6.76804856919672e-08 8.21244917847651e-06 1.3121856996975 0.485294117647059 14.2 14 2 pericardial edema 0.000121760332565671 0.00432684038938724 1.3121856996975 0.485294117647059 14.2 14 2 decreased circulating LDL cholesterol level 0.000201920930202735 0.00648101050166845 1.30970049950868 0.484375 14.2 14 2 hypoglycemia 8.59655157239677e-06 0.000464867870355152 1.30833764779223 0.483870967741935 14.2 14 2 male infertility 9.18879061886689e-25 1.14285583322157e-21 1.3062567926864 0.483101391650099 14.2 14 2 abnormal embryonic neuroepithelium morphology 0.000432520671058978 0.0122260814688546 1.30532997503868 0.482758620689655 14.2 14 2 blood in lymph vessels 0.0115608478135212 0.122633726806541 1.30532997503868 0.482758620689655 14.2 14 2 impaired limb coordination 0.000720405969918401 0.0172308639439618 1.30187672113647 0.481481481481481 14.2 14 2 abnormal trigeminal ganglion morphology 0.0151481000340477 0.144892634308577 1.30187672113647 0.481481481481481 14.2 14 2 decreased circulating fructosamine level 0.0151481000340477 0.144892634308577 1.30187672113647 0.481481481481481 14.2 14 2 abnormal bone trabecula morphology 0.0151481000340477 0.144892634308577 1.30187672113647 0.481481481481481 14.2 14 2 distended pericardium 0.000930494053632211 0.0202148817328395 1.29995086799869 0.480769230769231 14.2 14 2 embryonic growth arrest 8.04087266471614e-12 2.00016707534814e-09 1.2988155397297 0.480349344978166 14.2 14 2 embryonic lethality before implantation, complete penetrance 4.21903834288216e-07 3.55757894166758e-05 1.29787094660989 0.48 14.2 14 2 testicular atrophy 0.00120256276100122 0.024027107373418 1.29787094660989 0.48 14.2 14 2 ruffled hair 0.019892496066468 0.164393966662256 1.29787094660989 0.48 14.2 14 2 increased cellular sensitivity to ionizing radiation 0.019892496066468 0.164393966662256 1.29787094660989 0.48 14.2 14 2 abnormal cochlear outer hair cell morphology 0.019892496066468 0.164393966662256 1.29787094660989 0.48 14.2 14 2 curly tail 0.00155517798161479 0.0283406976503062 1.29561769843869 0.479166666666667 14.2 14 2 abnormal cell cycle 1.44768020459505e-06 0.000101439563631836 1.29316851564391 0.478260869565217 14.2 14 2 failure to gastrulate 0.00201258099637041 0.0342714639236127 1.29316851564391 0.478260869565217 14.2 14 2 abnormal postnatal growth 0.0261898268136803 0.201071587034042 1.29316851564391 0.478260869565217 14.2 14 2 abnormal sacral vertebrae morphology 0.0261898268136803 0.201071587034042 1.29316851564391 0.478260869565217 14.2 14 2 abnormal Wolffian duct morphology 0.0261898268136803 0.201071587034042 1.29316851564391 0.478260869565217 14.2 14 2 abnormal chondrocyte physiology 0.0261898268136803 0.201071587034042 1.29316851564391 0.478260869565217 14.2 14 2 abnormal hepatocyte morphology 2.37174523474403e-06 0.000153239383673397 1.29105030349708 0.477477477477477 14.2 14 2 abnormal bone structure 6.51486201155799e-10 1.29645754030004e-07 1.28890465336906 0.476683937823834 14.2 14 2 decreased circulating HDL cholesterol level 4.64733236251531e-07 3.79024237762519e-05 1.2885762979037 0.4765625 14.2 14 2 abnormal pancreas morphology 0.00337837467331557 0.049288604104824 1.28757038354156 0.476190476190476 14.2 14 2 left pulmonary isomerism 0.0345840164418542 0.24301621722913 1.28757038354156 0.476190476190476 14.2 14 2 abnormal erythrocyte physiology 0.0345840164418542 0.24301621722913 1.28757038354156 0.476190476190476 14.2 14 2 abnormal clavicle morphology 0.0345840164418542 0.24301621722913 1.28757038354156 0.476190476190476 14.2 14 2 increased circulating HDL cholesterol level 4.97645172476669e-06 0.000294736277746599 1.28757038354156 0.476190476190476 14.2 14 2 abnormal craniofacial morphology 6.37203786138017e-06 0.000364378027130648 1.28632031520802 0.475728155339806 14.2 14 2 kyphoscoliosis 0.0458306941490764 0.289349877400578 1.28079369731239 0.473684210526316 14.2 14 2 small superior vagus ganglion 0.0458306941490764 0.289349877400578 1.28079369731239 0.473684210526316 14.2 14 2 stereotypic behavior 0.0458306941490764 0.289349877400578 1.28079369731239 0.473684210526316 14.2 14 2 abnormal optic vesicle formation 0.0458306941490764 0.289349877400578 1.28079369731239 0.473684210526316 14.2 14 2 embryonic lethality, complete penetrance 5.51991785901027e-15 2.49650830441601e-12 1.27990146903144 0.473354231974922 14.2 14 2 decreased circulating glucose level 2.87402165531631e-13 8.93641108449915e-11 1.27926347784129 0.473118279569892 14.2 14 2 reduced long term depression 0.00739862397636312 0.0867045687014626 1.27684063034538 0.472222222222222 14.2 14 2 abnormal lysosome morphology 0.00739862397636312 0.0867045687014626 1.27684063034538 0.472222222222222 14.2 14 2 anophthalmia 3.60577472808115e-05 0.00158749816568174 1.27599671717265 0.471910112359551 14.2 14 2 extramedullary hematopoiesis 6.96123276168232e-06 0.000384801477659662 1.27542349313079 0.471698113207547 14.2 14 2 prenatal lethality, complete penetrance 5.09332867409868e-13 1.49054765609653e-10 1.27413889392908 0.471223021582734 14.2 14 2 small testis 6.49065390289271e-13 1.79394462038285e-10 1.27357505328567 0.471014492753623 14.2 14 2 edema 1.32715306816457e-08 1.83405180947743e-06 1.27334722232802 0.47093023255814 14.2 14 2 decreased mean corpuscular hemoglobin 0.000312821363671993 0.00931907954651597 1.27242249667636 0.470588235294118 14.2 14 2 overexpanded pulmonary alveoli 0.00962942653321494 0.106093240808501 1.27242249667636 0.470588235294118 14.2 14 2 increased width of hypertrophic chondrocyte zone 0.00962942653321494 0.106093240808501 1.27242249667636 0.470588235294118 14.2 14 2 abnormal direction of heart looping 0.00962942653321494 0.106093240808501 1.27242249667636 0.470588235294118 14.2 14 2 hyperlipidemia 0.0609939682192975 0.333625488080865 1.27242249667636 0.470588235294118 14.2 14 2 coloboma 0.0609939682192975 0.333625488080865 1.27242249667636 0.470588235294118 14.2 14 2 enhanced behavioral response to cocaine 0.0609939682192975 0.333625488080865 1.27242249667636 0.470588235294118 14.2 14 2 increased circulating magnesium level 0.0609939682192975 0.333625488080865 1.27242249667636 0.470588235294118 14.2 14 2 abnormal gastrulation 0.00169551061271278 0.0304518602824767 1.27242249667636 0.470588235294118 14.2 14 2 increased sarcoma incidence 0.00218953543893399 0.0359420654213724 1.26917652091954 0.469387755102041 14.2 14 2 abnormal embryo size 4.62595832122469e-06 0.000280660276196254 1.26819985564757 0.469026548672566 14.2 14 2 decreased caudal vertebrae number 0.000516999996581117 0.0137029660359075 1.26745209629872 0.46875 14.2 14 2 kidney cortex cysts 0.0125493739730733 0.126382865417085 1.26745209629872 0.46875 14.2 14 2 failure of primitive streak formation 0.0125493739730733 0.126382865417085 1.26745209629872 0.46875 14.2 14 2 abnormal lumbar vertebrae morphology 0.0125493739730733 0.126382865417085 1.26745209629872 0.46875 14.2 14 2 abnormal placenta morphology 0.000124795567780242 0.00437223908244157 1.26638251647062 0.468354430379747 14.2 14 2 abnormal myocardium layer morphology 0.000124795567780242 0.00437223908244157 1.26638251647062 0.468354430379747 14.2 14 2 prenatal lethality, incomplete penetrance 1.29895554025196e-13 4.30820254183566e-11 1.26300489596083 0.467105263157895 14.2 14 2 trabecula carnea hypoplasia 0.00365783712874625 0.0529004061497459 1.26181897587073 0.466666666666667 14.2 14 2 abnormal spleen marginal zone morphology 0.0163787942862872 0.153454805224631 1.26181897587073 0.466666666666667 14.2 14 2 abnormal fontanelle morphology 0.0815987423607209 0.373462505284808 1.26181897587073 0.466666666666667 14.2 14 2 macrocytosis 0.0815987423607209 0.373462505284808 1.26181897587073 0.466666666666667 14.2 14 2 abnormal pup retrieval 0.0815987423607209 0.373462505284808 1.26181897587073 0.466666666666667 14.2 14 2 placental labyrinth hypoplasia 0.0815987423607209 0.373462505284808 1.26181897587073 0.466666666666667 14.2 14 2 abnormal glial cell morphology 0.0815987423607209 0.373462505284808 1.26181897587073 0.466666666666667 14.2 14 2 absent chorion 0.0815987423607209 0.373462505284808 1.26181897587073 0.466666666666667 14.2 14 2 astrocytosis 0.000263311529594535 0.0080366555811829 1.2593496628064 0.465753424657534 14.2 14 2 abnormal left-right axis patterning 0.00473244081871423 0.0627837148616088 1.2576268862499 0.465116279069767 14.2 14 2 abnormal double-strand DNA break repair 0.00473244081871423 0.0627837148616088 1.2576268862499 0.465116279069767 14.2 14 2 preweaning lethality, incomplete penetrance 2.11130204544767e-17 1.05037276761021e-14 1.25608944506866 0.464547677261614 14.2 14 2 abnormal ovulation 0.0214120310370538 0.172091848803462 1.25538112395302 0.464285714285714 14.2 14 2 preweaning lethality, complete penetrance 4.20569091566821e-30 2.09233123054494e-26 1.25329317197971 0.463513513513513 14.2 14 2 thick ventricular wall 0.0061271628107105 0.0756081977626172 1.25302581227581 0.463414634146341 14.2 14 2 increased bone trabecula number 0.0061271628107105 0.0756081977626172 1.25302581227581 0.463414634146341 14.2 14 2 lethality at weaning, incomplete penetrance 0.0061271628107105 0.0756081977626172 1.25302581227581 0.463414634146341 14.2 14 2 decreased birth weight 4.21288381440556e-05 0.00180188590287291 1.2523316151499 0.463157894736842 14.2 14 2 decreased white adipose tissue amount 0.000556402754517393 0.0143425062369121 1.25105719356053 0.462686567164179 14.2 14 2 increased insulin sensitivity 6.96830354625895e-07 5.25262274888459e-05 1.24795283327874 0.461538461538462 14.2 14 2 increased circulating alanine transaminase level 0.000220522818773585 0.00698790460763429 1.24795283327874 0.461538461538462 14.2 14 2 abnormal nasal bone morphology 0.0280441600178249 0.212036012292825 1.24795283327874 0.461538461538462 14.2 14 2 increased susceptibility to otitis media 0.0280441600178249 0.212036012292825 1.24795283327874 0.461538461538462 14.2 14 2 decreased circulating glycerol level 0.0280441600178249 0.212036012292825 1.24795283327874 0.461538461538462 14.2 14 2 absent trabeculae carneae 0.109880953466772 0.448469571359015 1.24795283327874 0.461538461538462 14.2 14 2 abnormal mast cell morphology 0.109880953466772 0.448469571359015 1.24795283327874 0.461538461538462 14.2 14 2 abnormal sympathetic ganglion morphology 0.109880953466772 0.448469571359015 1.24795283327874 0.461538461538462 14.2 14 2 abnormal otolith morphology 0.109880953466772 0.448469571359015 1.24795283327874 0.461538461538462 14.2 14 2 abnormal soleus morphology 0.109880953466772 0.448469571359015 1.24795283327874 0.461538461538462 14.2 14 2 axonal dystrophy 0.109880953466772 0.448469571359015 1.24795283327874 0.461538461538462 14.2 14 2 abnormal retinal inner plexiform layer morphology 0.109880953466772 0.448469571359015 1.24795283327874 0.461538461538462 14.2 14 2 small otic vesicle 0.109880953466772 0.448469571359015 1.24795283327874 0.461538461538462 14.2 14 2 small pituitary gland 0.109880953466772 0.448469571359015 1.24795283327874 0.461538461538462 14.2 14 2 orthokeratosis 0.109880953466772 0.448469571359015 1.24795283327874 0.461538461538462 14.2 14 2 abnormal aorta tunica media morphology 0.109880953466772 0.448469571359015 1.24795283327874 0.461538461538462 14.2 14 2 absent hypoglossal nerve 0.109880953466772 0.448469571359015 1.24795283327874 0.461538461538462 14.2 14 2 decreased total body fat amount 4.76891568207355e-14 1.69466825130828e-11 1.24670737136928 0.461077844311377 14.2 14 2 increased circulating aspartate transaminase level 0.000917066076328719 0.020010542674278 1.24465137075684 0.46031746031746 14.2 14 2 abnormal liver physiology 3.53225230768995e-05 0.00156901385988906 1.24379299050115 0.46 14.2 14 2 increased body length 0.00303028994235821 0.045962477022049 1.24379299050115 0.46 14.2 14 2 decreased circulating alkaline phosphatase level 0.00303028994235821 0.045962477022049 1.24379299050115 0.46 14.2 14 2 malocclusion 0.0102956826899502 0.111592639177565 1.24233142411983 0.459459459459459 14.2 14 2 impaired skeletal muscle contractility 0.0102956826899502 0.111592639177565 1.24233142411983 0.459459459459459 14.2 14 2 abnormal foregut morphology 0.0368083928221246 0.247780930160264 1.23928649415875 0.458333333333333 14.2 14 2 decreased body height 0.0368083928221246 0.247780930160264 1.23928649415875 0.458333333333333 14.2 14 2 abnormal body weight 0.0368083928221246 0.247780930160264 1.23928649415875 0.458333333333333 14.2 14 2 abnormal nursing 0.0368083928221246 0.247780930160264 1.23928649415875 0.458333333333333 14.2 14 2 hemolytic anemia 0.0368083928221246 0.247780930160264 1.23928649415875 0.458333333333333 14.2 14 2 abnormal impulse conducting system conduction 0.0368083928221246 0.247780930160264 1.23928649415875 0.458333333333333 14.2 14 2 decreased ovulation rate 0.0368083928221246 0.247780930160264 1.23928649415875 0.458333333333333 14.2 14 2 reduced male fertility 8.81033377379675e-10 1.58285068587628e-07 1.23879018398888 0.458149779735683 14.2 14 2 abnormal thoracic vertebrae morphology 0.00151271948813618 0.0281951195231278 1.23737696181028 0.457627118644068 14.2 14 2 increased hemoglobin content 0.00151271948813618 0.0281951195231278 1.23737696181028 0.457627118644068 14.2 14 2 decreased glycogen level 0.0133640575008592 0.132442601726643 1.2360675681999 0.457142857142857 14.2 14 2 increased red blood cell distribution width 0.0133640575008592 0.132442601726643 1.2360675681999 0.457142857142857 14.2 14 2 decreased bone volume 0.0133640575008592 0.132442601726643 1.2360675681999 0.457142857142857 14.2 14 2 decreased bone mineralization 0.0133640575008592 0.132442601726643 1.2360675681999 0.457142857142857 14.2 14 2 absent vitelline blood vessels 0.00194345530234567 0.0336888157810791 1.23335689370823 0.456140350877193 14.2 14 2 increased hepatocellular carcinoma incidence 0.00194345530234567 0.0336888157810791 1.23335689370823 0.456140350877193 14.2 14 2 abnormal gametogenesis 0.00650408163078018 0.0785383643522607 1.22904445701694 0.454545454545455 14.2 14 2 decreased blood urea nitrogen level 0.00650408163078018 0.0785383643522607 1.22904445701694 0.454545454545455 14.2 14 2 abnormal skeleton physiology 0.0173643804289736 0.160274197837001 1.22904445701694 0.454545454545455 14.2 14 2 abnormal enterocyte morphology 0.0484290835691325 0.290948891067549 1.22904445701694 0.454545454545455 14.2 14 2 abnormal facial nerve morphology 0.0484290835691325 0.290948891067549 1.22904445701694 0.454545454545455 14.2 14 2 abnormal germ layer development 0.0484290835691325 0.290948891067549 1.22904445701694 0.454545454545455 14.2 14 2 increased activated T cell number 0.0484290835691325 0.290948891067549 1.22904445701694 0.454545454545455 14.2 14 2 intracerebral hemorrhage 0.0484290835691325 0.290948891067549 1.22904445701694 0.454545454545455 14.2 14 2 aphakia 0.0484290835691325 0.290948891067549 1.22904445701694 0.454545454545455 14.2 14 2 abnormal blood-brain barrier function 0.0484290835691325 0.290948891067549 1.22904445701694 0.454545454545455 14.2 14 2 enlarged cranium 0.14922234939328 0.52655711864879 1.22904445701694 0.454545454545455 14.2 14 2 abnormal stomach epithelium morphology 0.14922234939328 0.52655711864879 1.22904445701694 0.454545454545455 14.2 14 2 abnormal large intestine morphology 0.14922234939328 0.52655711864879 1.22904445701694 0.454545454545455 14.2 14 2 abnormal enteric ganglia morphology 0.14922234939328 0.52655711864879 1.22904445701694 0.454545454545455 14.2 14 2 abnormal glossopharyngeal ganglion morphology 0.14922234939328 0.52655711864879 1.22904445701694 0.454545454545455 14.2 14 2 abnormal food preference 0.14922234939328 0.52655711864879 1.22904445701694 0.454545454545455 14.2 14 2 abnormal fear/anxiety-related behavior 0.14922234939328 0.52655711864879 1.22904445701694 0.454545454545455 14.2 14 2 abnormal bronchiole morphology 0.14922234939328 0.52655711864879 1.22904445701694 0.454545454545455 14.2 14 2 pulmonary hypertension 0.14922234939328 0.52655711864879 1.22904445701694 0.454545454545455 14.2 14 2 abnormal ureter development 0.14922234939328 0.52655711864879 1.22904445701694 0.454545454545455 14.2 14 2 abnormal hair medulla 0.14922234939328 0.52655711864879 1.22904445701694 0.454545454545455 14.2 14 2 abnormal dorsal-ventral polarity of the somites 0.14922234939328 0.52655711864879 1.22904445701694 0.454545454545455 14.2 14 2 abnormal superovulation 0.14922234939328 0.52655711864879 1.22904445701694 0.454545454545455 14.2 14 2 palatal shelf hypoplasia 0.14922234939328 0.52655711864879 1.22904445701694 0.454545454545455 14.2 14 2 aberrant origin of the right subclavian artery 0.14922234939328 0.52655711864879 1.22904445701694 0.454545454545455 14.2 14 2 common atrioventricular valve 0.14922234939328 0.52655711864879 1.22904445701694 0.454545454545455 14.2 14 2 abnormal extraembryonic ectoderm morphology 0.14922234939328 0.52655711864879 1.22904445701694 0.454545454545455 14.2 14 2 decreased core body temperature 0.14922234939328 0.52655711864879 1.22904445701694 0.454545454545455 14.2 14 2 abnormal brain ependyma motile cilium morphology 0.14922234939328 0.52655711864879 1.22904445701694 0.454545454545455 14.2 14 2 abnormal phrenic nerve innervation pattern to diaphragm 0.14922234939328 0.52655711864879 1.22904445701694 0.454545454545455 14.2 14 2 spleen hyperplasia 0.000491499646921367 0.0133618073411683 1.22576700513156 0.453333333333333 14.2 14 2 abnormal mesoderm development 0.00320992746060456 0.0472467133624487 1.22440655340556 0.452830188679245 14.2 14 2 increased circulating bilirubin level 0.00320992746060456 0.0472467133624487 1.22440655340556 0.452830188679245 14.2 14 2 atrioventricular septal defect 0.00320992746060456 0.0472467133624487 1.22440655340556 0.452830188679245 14.2 14 2 abnormal vitelline vasculature morphology 2.04627186723341e-05 0.000998059072498649 1.22263205115425 0.452173913043478 14.2 14 2 abnormal nervous system physiology 2.04627186723341e-05 0.000998059072498649 1.22263205115425 0.452173913043478 14.2 14 2 abnormal seminiferous tubule morphology 1.728904753931e-06 0.000119462515983427 1.22230996684151 0.452054794520548 14.2 14 2 abnormal fertility/fecundity 0.000628408339074844 0.0155538879945142 1.22230996684151 0.452054794520548 14.2 14 2 small cranium 0.0225870433909953 0.178933982277391 1.22111513793941 0.451612903225806 14.2 14 2 abnormal spermatogenesis 9.74860707614842e-08 1.12789116753113e-05 1.21969303180051 0.451086956521739 14.2 14 2 hemorrhage 1.79879323231456e-09 2.79656135336404e-07 1.21963049947383 0.451063829787234 14.2 14 2 increased lung adenocarcinoma incidence 0.00412671582028125 0.0576696943985934 1.21940489264818 0.450980392156863 14.2 14 2 small lung 0.00412671582028125 0.0576696943985934 1.21940489264818 0.450980392156863 14.2 14 2 failure of chorioallantoic fusion 0.00412671582028125 0.0576696943985934 1.21940489264818 0.450980392156863 14.2 14 2 decreased liver weight 0.000803445987052143 0.0186782419887122 1.21865816583088 0.450704225352113 14.2 14 2 abnormal vascular regression 0.0638979468597224 0.3367822805716 1.21675401244677 0.45 14.2 14 2 small gonad 0.0638979468597224 0.3367822805716 1.21675401244677 0.45 14.2 14 2 abnormal fibula morphology 0.0638979468597224 0.3367822805716 1.21675401244677 0.45 14.2 14 2 abnormal incus morphology 0.0638979468597224 0.3367822805716 1.21675401244677 0.45 14.2 14 2 abnormal response to tactile stimuli 0.0638979468597224 0.3367822805716 1.21675401244677 0.45 14.2 14 2 abnormal heart electrocardiography waveform feature 0.0638979468597224 0.3367822805716 1.21675401244677 0.45 14.2 14 2 abnormal behavior 8.61238555334683e-11 1.8628964403435e-08 1.2157813873369 0.449640287769784 14.2 14 2 increased lymphocyte cell number 0.0010272211382276 0.0216543439096707 1.21479466621095 0.449275362318841 14.2 14 2 abnormal excitatory postsynaptic currents 0.000517820626080526 0.0137029660359075 1.21328747679878 0.448717948717949 14.2 14 2 thrombocytopenia 2.93557169989926e-06 0.00018486669882277 1.21209211967878 0.448275862068966 14.2 14 2 abnormal parietal bone morphology 0.0294161174061742 0.216167184779493 1.21209211967878 0.448275862068966 14.2 14 2 lordosis 0.0294161174061742 0.216167184779493 1.21209211967878 0.448275862068966 14.2 14 2 abnormal circulating glucose level 0.0294161174061742 0.216167184779493 1.21209211967878 0.448275862068966 14.2 14 2 polychromatophilia 0.0294161174061742 0.216167184779493 1.21209211967878 0.448275862068966 14.2 14 2 decreased circulating cholesterol level 1.64954530028979e-07 1.70968497269619e-05 1.2115826232014 0.448087431693989 14.2 14 2 hepatic necrosis 0.00682543189669654 0.0810418226397739 1.20812455136559 0.446808510638298 14.2 14 2 increased cellular sensitivity to gamma-irradiation 0.00682543189669654 0.0810418226397739 1.20812455136559 0.446808510638298 14.2 14 2 abnormal eye development 0.00336850785898975 0.049288604104824 1.20709723457021 0.446428571428571 14.2 14 2 abnormal bone mineralization 2.26618595873492e-05 0.00105367057427161 1.20669819416209 0.446280991735537 14.2 14 2 abnormal angiogenesis 0.000843044513151352 0.0189780382485429 1.20579226458689 0.445945945945946 14.2 14 2 abnormal glucose homeostasis 2.77319600029397e-07 2.52099042891567e-05 1.20338308923307 0.445054945054945 14.2 14 2 increased circulating alkaline phosphatase level 1.314303531143e-06 9.47631893831368e-05 1.20173235797212 0.444444444444444 14.2 14 2 abnormal skeleton development 0.000542262076196867 0.014174542707484 1.20173235797212 0.444444444444444 14.2 14 2 abnormal forebrain development 0.00107551111598578 0.0222019410872582 1.20173235797212 0.444444444444444 14.2 14 2 abnormal cell adhesion 0.00431780472123679 0.0600030125367403 1.20173235797212 0.444444444444444 14.2 14 2 abnormal long bone epiphyseal plate proliferative zone 0.00431780472123679 0.0600030125367403 1.20173235797212 0.444444444444444 14.2 14 2 abnormal metabolism 0.00878107723240731 0.0999676412613876 1.20173235797212 0.444444444444444 14.2 14 2 renal hypoplasia 0.018136404320456 0.161410754014792 1.20173235797212 0.444444444444444 14.2 14 2 abnormal fetal cardiomyocyte proliferation 0.0383610080048466 0.25078319950606 1.20173235797212 0.444444444444444 14.2 14 2 lowered ear position 0.0845855741719615 0.379452868805688 1.20173235797212 0.444444444444444 14.2 14 2 abnormal heart shape 0.0845855741719615 0.379452868805688 1.20173235797212 0.444444444444444 14.2 14 2 cortical renal glomerulopathies 0.0845855741719615 0.379452868805688 1.20173235797212 0.444444444444444 14.2 14 2 abnormal radius morphology 0.0845855741719615 0.379452868805688 1.20173235797212 0.444444444444444 14.2 14 2 abnormal retinal rod cell morphology 0.0845855741719615 0.379452868805688 1.20173235797212 0.444444444444444 14.2 14 2 acidosis 0.0845855741719615 0.379452868805688 1.20173235797212 0.444444444444444 14.2 14 2 abnormal metacarpal bone morphology 0.0845855741719615 0.379452868805688 1.20173235797212 0.444444444444444 14.2 14 2 increased circulating renin level 0.0845855741719615 0.379452868805688 1.20173235797212 0.444444444444444 14.2 14 2 abnormal body wall morphology 0.0845855741719615 0.379452868805688 1.20173235797212 0.444444444444444 14.2 14 2 absent ureter 0.0845855741719615 0.379452868805688 1.20173235797212 0.444444444444444 14.2 14 2 increased susceptibility to autoimmune disorder 0.0845855741719615 0.379452868805688 1.20173235797212 0.444444444444444 14.2 14 2 jerky movement 0.0845855741719615 0.379452868805688 1.20173235797212 0.444444444444444 14.2 14 2 abnormal macrophage chemotaxis 0.0845855741719615 0.379452868805688 1.20173235797212 0.444444444444444 14.2 14 2 increased effector memory CD8-positive, alpha-beta T cell number 0.0845855741719615 0.379452868805688 1.20173235797212 0.444444444444444 14.2 14 2 increased tumor incidence 2.37101216591101e-05 0.00109220236346364 1.19930951047621 0.443548387096774 14.2 14 2 decreased cell proliferation 2.90020398418515e-07 2.57652050380734e-05 1.19848443268031 0.443243243243243 14.2 14 2 domed cranium 0.00137190093821867 0.026870894360779 1.19744045669365 0.442857142857143 14.2 14 2 dehydration 0.00137190093821867 0.026870894360779 1.19744045669365 0.442857142857143 14.2 14 2 abnormal long bone morphology 0.00274361236185965 0.0418695444792999 1.19680722535748 0.442622950819672 14.2 14 2 decreased body temperature 0.00553485253587435 0.0704242745932862 1.19595479855879 0.442307692307692 14.2 14 2 abnormal vasculogenesis 0.0112997233519314 0.120119922384314 1.1947455419374 0.441860465116279 14.2 14 2 impaired macrophage phagocytosis 0.0112997233519314 0.120119922384314 1.1947455419374 0.441860465116279 14.2 14 2 delayed endochondral bone ossification 0.0112997233519314 0.120119922384314 1.1947455419374 0.441860465116279 14.2 14 2 abnormal brain morphology 2.19377412044578e-06 0.000143605608542339 1.19240213780153 0.440993788819876 14.2 14 2 abnormal definitive hematopoiesis 0.000286333511187345 0.00863338920095175 1.19204096798848 0.440860215053763 14.2 14 2 abnormal nest building behavior 0.0500994545587121 0.292993191880773 1.1897150343924 0.44 14.2 14 2 diaphragmatic hernia 0.0500994545587121 0.292993191880773 1.1897150343924 0.44 14.2 14 2 decreased placenta weight 0.0500994545587121 0.292993191880773 1.1897150343924 0.44 14.2 14 2 abnormal vertebrae development 0.0500994545587121 0.292993191880773 1.1897150343924 0.44 14.2 14 2 decreased bone mineral density 1.7102337386754e-09 2.74464930642261e-07 1.18930843321865 0.43984962406015 14.2 14 2 limb grasping 6.08945910204641e-07 4.66077831272014e-05 1.18852650788452 0.43956043956044 14.2 14 2 impaired swimming 0.00223118390821568 0.0363939014536819 1.18807630844971 0.439393939393939 14.2 14 2 hemopericardium 0.0145441211909071 0.142435045127486 1.18707708531393 0.439024390243902 14.2 14 2 abnormal eye morphology 1.32007342309321e-05 0.000677047966998839 1.18660263404082 0.438848920863309 14.2 14 2 decreased percent body fat/body weight 0.00142446938089187 0.0274270144263263 1.18527027087661 0.438356164383562 14.2 14 2 overriding aortic valve 0.00909524714830712 0.103072561646533 1.18295528987881 0.4375 14.2 14 2 abnormal retinal pigment epithelium morphology 0.000912054613343255 0.0199888621206286 1.18295528987881 0.4375 14.2 14 2 polydipsia 0.0303941196049344 0.222696237164284 1.18295528987881 0.4375 14.2 14 2 abnormal spongiotrophoblast layer morphology 0.0303941196049344 0.222696237164284 1.18295528987881 0.4375 14.2 14 2 poor circulation 0.112408032842715 0.448469571359015 1.18295528987881 0.4375 14.2 14 2 abnormal intestinal absorption 0.112408032842715 0.448469571359015 1.18295528987881 0.4375 14.2 14 2 intraventricular hemorrhage 0.112408032842715 0.448469571359015 1.18295528987881 0.4375 14.2 14 2 increased pancreatic beta cell number 0.112408032842715 0.448469571359015 1.18295528987881 0.4375 14.2 14 2 small pancreas 0.112408032842715 0.448469571359015 1.18295528987881 0.4375 14.2 14 2 increased cochlear outer hair cell number 0.112408032842715 0.448469571359015 1.18295528987881 0.4375 14.2 14 2 decreased circulating growth hormone level 0.112408032842715 0.448469571359015 1.18295528987881 0.4375 14.2 14 2 dystonia 0.112408032842715 0.448469571359015 1.18295528987881 0.4375 14.2 14 2 decreased creatinine clearance 0.112408032842715 0.448469571359015 1.18295528987881 0.4375 14.2 14 2 abnormal thoracic cage shape 0.112408032842715 0.448469571359015 1.18295528987881 0.4375 14.2 14 2 dilated respiratory conducting tubes 0.112408032842715 0.448469571359015 1.18295528987881 0.4375 14.2 14 2 abnormal retinal pigmentation 0.000585392356272003 0.0147833856469706 1.18101283455881 0.436781609195402 14.2 14 2 increased circulating free fatty acid level 0.00181245352537269 0.0323587966620818 1.18057509814867 0.436619718309859 14.2 14 2 increased rib number 0.00115852516836814 0.0238167880687251 1.17862212031881 0.435897435897436 14.2 14 2 failure of heart looping 0.0187241353057357 0.163699498285514 1.17862212031881 0.435897435897436 14.2 14 2 ataxia 2.78702459478115e-07 2.52099042891567e-05 1.17793567761624 0.435643564356436 14.2 14 2 abnormal blood vessel physiology 0.0655362041502494 0.3367822805716 1.17560774149447 0.434782608695652 14.2 14 2 abnormal innervation pattern to muscle 0.0655362041502494 0.3367822805716 1.17560774149447 0.434782608695652 14.2 14 2 failure of embryo implantation 0.0655362041502494 0.3367822805716 1.17560774149447 0.434782608695652 14.2 14 2 abnormal hepatocyte physiology 0.0655362041502494 0.3367822805716 1.17560774149447 0.434782608695652 14.2 14 2 abnormal hematopoietic stem cell physiology 0.0655362041502494 0.3367822805716 1.17560774149447 0.434782608695652 14.2 14 2 abnormal placenta development 0.00731729509358119 0.0862643201198256 1.17338961368033 0.433962264150943 14.2 14 2 lung inflammation 2.74898670569526e-05 0.00125469806062697 1.17301448912352 0.433823529411765 14.2 14 2 decreased insulin secretion 0.000604083627624188 0.0150265802371517 1.17168904902282 0.433333333333333 14.2 14 2 oxidative stress 0.000604083627624188 0.0150265802371517 1.17168904902282 0.433333333333333 14.2 14 2 epidermal hyperplasia 0.00462046235245342 0.0621264870363669 1.17168904902282 0.433333333333333 14.2 14 2 abnormal response to new environment 0.0393858350860876 0.255136106189174 1.17168904902282 0.433333333333333 14.2 14 2 disorganized myocardium 0.0393858350860876 0.255136106189174 1.17168904902282 0.433333333333333 14.2 14 2 abnormal microglial cell physiology 0.0393858350860876 0.255136106189174 1.17168904902282 0.433333333333333 14.2 14 2 abnormal brain vasculature morphology 0.0393858350860876 0.255136106189174 1.17168904902282 0.433333333333333 14.2 14 2 abnormal cellular respiration 0.0393858350860876 0.255136106189174 1.17168904902282 0.433333333333333 14.2 14 2 decreased bone mineral content 2.9712185804427e-07 2.5933004276671e-05 1.16995578119882 0.432692307692308 14.2 14 2 abnormal intestine morphology 0.00186745975631321 0.0329454336441781 1.16925310505396 0.432432432432432 14.2 14 2 kidney cysts 0.00186745975631321 0.0329454336441781 1.16925310505396 0.432432432432432 14.2 14 2 increased insulin secretion 0.0241102874675079 0.189193501815224 1.16925310505396 0.432432432432432 14.2 14 2 abnormal neural tube morphology 6.16006834477908e-06 0.000356352790875301 1.16835090358401 0.432098765432099 14.2 14 2 decreased heart weight 0.00119341850030246 0.024027107373418 1.16835090358401 0.432098765432099 14.2 14 2 insulin resistance 4.36903563227094e-05 0.00182655061097041 1.1675922341661 0.431818181818182 14.2 14 2 increased T cell number 0.000764742817994074 0.017861950795871 1.1675922341661 0.431818181818182 14.2 14 2 impaired hematopoiesis 0.00934700858237881 0.104497455499628 1.16638728862 0.431372549019608 14.2 14 2 abnormal thrombosis 0.00934700858237881 0.104497455499628 1.16638728862 0.431372549019608 14.2 14 2 neonatal lethality, incomplete penetrance 1.54200669157774e-08 2.07337386232412e-06 1.16475597772683 0.430769230769231 14.2 14 2 abnormal lipid homeostasis 5.5049358027064e-05 0.00224484062446429 1.16475597772683 0.430769230769231 14.2 14 2 lethality throughout fetal growth and development, incomplete penetrance 2.68088285163697e-06 0.000170992207524281 1.16312922356799 0.430167597765363 14.2 14 2 decreased grip strength 2.57402730928413e-07 2.4161860120167e-05 1.16057714023335 0.429223744292237 14.2 14 2 disheveled coat 0.0191537864561468 0.163699498285514 1.1588133451874 0.428571428571429 14.2 14 2 abnormal spleen white pulp morphology 0.0191537864561468 0.163699498285514 1.1588133451874 0.428571428571429 14.2 14 2 abnormal eye pigmentation 0.0858833946731234 0.380559062389784 1.1588133451874 0.428571428571429 14.2 14 2 abnormal hematopoietic system physiology 0.0858833946731234 0.380559062389784 1.1588133451874 0.428571428571429 14.2 14 2 complete atrioventricular septal defect 0.0858833946731234 0.380559062389784 1.1588133451874 0.428571428571429 14.2 14 2 embryonic lethality at implantation, complete penetrance 0.0858833946731234 0.380559062389784 1.1588133451874 0.428571428571429 14.2 14 2 abnormal respiratory system physiology 0.0119367374420343 0.123462097243495 1.1588133451874 0.428571428571429 14.2 14 2 ovary cysts 0.031051072086305 0.224214059969107 1.1588133451874 0.428571428571429 14.2 14 2 abnormal midbrain development 0.031051072086305 0.224214059969107 1.1588133451874 0.428571428571429 14.2 14 2 holoprosencephaly 0.031051072086305 0.224214059969107 1.1588133451874 0.428571428571429 14.2 14 2 decreased triglyceride level 0.031051072086305 0.224214059969107 1.1588133451874 0.428571428571429 14.2 14 2 rib bifurcation 0.0510727407306911 0.296484113343277 1.1588133451874 0.428571428571429 14.2 14 2 myoclonus 0.0510727407306911 0.296484113343277 1.1588133451874 0.428571428571429 14.2 14 2 abnormal somite shape 0.0510727407306911 0.296484113343277 1.1588133451874 0.428571428571429 14.2 14 2 premature aging 0.0510727407306911 0.296484113343277 1.1588133451874 0.428571428571429 14.2 14 2 hypoxia 0.0510727407306911 0.296484113343277 1.1588133451874 0.428571428571429 14.2 14 2 midline facial cleft 0.150082008893263 0.52655711864879 1.1588133451874 0.428571428571429 14.2 14 2 abnormal kidney blood vessel morphology 0.150082008893263 0.52655711864879 1.1588133451874 0.428571428571429 14.2 14 2 absent visceral yolk sac blood islands 0.150082008893263 0.52655711864879 1.1588133451874 0.428571428571429 14.2 14 2 amyloid beta deposits 0.150082008893263 0.52655711864879 1.1588133451874 0.428571428571429 14.2 14 2 abnormal uterus development 0.150082008893263 0.52655711864879 1.1588133451874 0.428571428571429 14.2 14 2 abnormal hair cuticle 0.150082008893263 0.52655711864879 1.1588133451874 0.428571428571429 14.2 14 2 abnormal pancreas development 0.150082008893263 0.52655711864879 1.1588133451874 0.428571428571429 14.2 14 2 increased B-1 B cell number 0.150082008893263 0.52655711864879 1.1588133451874 0.428571428571429 14.2 14 2 decreased CNS synapse formation 0.150082008893263 0.52655711864879 1.1588133451874 0.428571428571429 14.2 14 2 increased circulating growth hormone level 0.150082008893263 0.52655711864879 1.1588133451874 0.428571428571429 14.2 14 2 spina bifida occulta 0.150082008893263 0.52655711864879 1.1588133451874 0.428571428571429 14.2 14 2 sternebra fusion 0.150082008893263 0.52655711864879 1.1588133451874 0.428571428571429 14.2 14 2 decreased compact bone area 0.150082008893263 0.52655711864879 1.1588133451874 0.428571428571429 14.2 14 2 abnormal vitelline vein topology 0.150082008893263 0.52655711864879 1.1588133451874 0.428571428571429 14.2 14 2 decreased litter size 8.90313564581089e-09 1.26551713822598e-06 1.15468945427926 0.427046263345196 14.2 14 2 decreased rib number 0.000990788696851809 0.0210648451574263 1.15447322029906 0.426966292134831 14.2 14 2 sparse hair 0.00154759322052892 0.0283061627651889 1.15410272183298 0.426829268292683 14.2 14 2 abnormal developmental patterning 0.00154759322052892 0.0283061627651889 1.15410272183298 0.426829268292683 14.2 14 2 decreased erythrocyte cell number 1.57808256623087e-05 0.000793026340100868 1.15389269404011 0.426751592356688 14.2 14 2 decreased circulating alanine transaminase level 0.00381058858711431 0.0547260756097293 1.15313288761296 0.426470588235294 14.2 14 2 embryonic lethality during organogenesis, incomplete penetrance 2.20865805293125e-07 2.18724744114354e-05 1.15209558666458 0.426086956521739 14.2 14 2 neurodegeneration 0.00954272343435282 0.106093240808501 1.15166017638995 0.425925925925926 14.2 14 2 abnormal pulmonary alveolus morphology 0.000515313010231007 0.0137029660359075 1.15116441221587 0.425742574257426 14.2 14 2 abnormal tibia morphology 0.0152393208647251 0.145240653835263 1.15059481082437 0.425531914893617 14.2 14 2 premature death 2.15767729271752e-23 1.78907408854494e-20 1.14939209847856 0.425087108013937 14.2 14 2 liver inflammation 0.000173730315061078 0.00583992106370854 1.14915656731084 0.425 14.2 14 2 abnormal tail morphology 0.00482865885788736 0.0638898346223127 1.14710815988248 0.424242424242424 14.2 14 2 abnormal aorta morphology 0.0399949800503793 0.258409124351477 1.14710815988248 0.424242424242424 14.2 14 2 decreased circulating serum albumin level 0.000649042089838373 0.0158283548869897 1.14710815988248 0.424242424242424 14.2 14 2 abnormal heart development 2.02216058046692e-05 0.000998059072498649 1.1465895757234 0.424050632911392 14.2 14 2 abnormal gait 3.31339888981858e-09 4.99519984146892e-07 1.14631266185205 0.423948220064725 14.2 14 2 abnormal locomotor behavior 0.00101079986469494 0.0213988481993928 1.14621754795711 0.423913043478261 14.2 14 2 cardiac fibrosis 0.00157787114925639 0.0286493028012793 1.14518024700873 0.423529411764706 14.2 14 2 impaired glucose tolerance 1.22661310296144e-07 1.32660873635504e-05 1.1447954418182 0.423387096774194 14.2 14 2 abnormal cornea morphology 0.00246984846360843 0.039637084214361 1.14395676383885 0.423076923076923 14.2 14 2 abnormal snout morphology 0.0121425896831487 0.125330671522127 1.14395676383885 0.423076923076923 14.2 14 2 small seminal vesicle 0.0662733372220294 0.3367822805716 1.14395676383885 0.423076923076923 14.2 14 2 abnormal nerve conduction 0.0662733372220294 0.3367822805716 1.14395676383885 0.423076923076923 14.2 14 2 abnormal ovarian follicle morphology 0.019448385780175 0.163699498285514 1.14164574007352 0.422222222222222 14.2 14 2 abnormal cell migration 0.019448385780175 0.163699498285514 1.14164574007352 0.422222222222222 14.2 14 2 seizures 0.000344228155353637 0.0100768949956477 1.13848328649991 0.421052631578947 14.2 14 2 abnormal axial skeleton morphology 0.00311744140829749 0.0464349431325749 1.13848328649991 0.421052631578947 14.2 14 2 abnormal reproductive system physiology 0.0314465109185151 0.224214059969107 1.13848328649991 0.421052631578947 14.2 14 2 decreased threshold for auditory brainstem response 0.0314465109185151 0.224214059969107 1.13848328649991 0.421052631578947 14.2 14 2 thin dermal layer 0.112770941461332 0.448469571359015 1.13848328649991 0.421052631578947 14.2 14 2 decreased grooming behavior 0.112770941461332 0.448469571359015 1.13848328649991 0.421052631578947 14.2 14 2 increased malignant tumor incidence 0.112770941461332 0.448469571359015 1.13848328649991 0.421052631578947 14.2 14 2 decreased tumor incidence 0.112770941461332 0.448469571359015 1.13848328649991 0.421052631578947 14.2 14 2 abnormal neurotransmitter level 0.112770941461332 0.448469571359015 1.13848328649991 0.421052631578947 14.2 14 2 abnormal neural crest cell migration 0.112770941461332 0.448469571359015 1.13848328649991 0.421052631578947 14.2 14 2 increased susceptibility to ischemic brain injury 0.112770941461332 0.448469571359015 1.13848328649991 0.421052631578947 14.2 14 2 abnormal response to novelty 0.112770941461332 0.448469571359015 1.13848328649991 0.421052631578947 14.2 14 2 absent amnion 0.112770941461332 0.448469571359015 1.13848328649991 0.421052631578947 14.2 14 2 increased circulating VLDL cholesterol level 0.112770941461332 0.448469571359015 1.13848328649991 0.421052631578947 14.2 14 2 thin interventricular septum 0.112770941461332 0.448469571359015 1.13848328649991 0.421052631578947 14.2 14 2 abnormal suckling behavior 0.00160320898298318 0.0290035079648775 1.13686612274067 0.420454545454545 14.2 14 2 microcephaly 0.00490179950165451 0.0643442019016654 1.13642081677799 0.420289855072464 14.2 14 2 decreased spleen weight 0.00490179950165451 0.0643442019016654 1.13642081677799 0.420289855072464 14.2 14 2 increased monocyte cell number 0.00082995633385019 0.0189780382485429 1.13563707828366 0.42 14.2 14 2 kyphosis 4.97164178962891e-05 0.0020441254465623 1.13563707828366 0.42 14.2 14 2 increased neuron apoptosis 0.00250698946541192 0.0401037703872164 1.13496944919589 0.419753086419753 14.2 14 2 increased lung adenoma incidence 0.0515182957547654 0.297242241604061 1.1338926280866 0.419354838709677 14.2 14 2 abnormal capillary morphology 0.0515182957547654 0.297242241604061 1.1338926280866 0.419354838709677 14.2 14 2 ventricular septal defect 0.000118287923668057 0.00423368647660851 1.13325128610239 0.419117647058824 14.2 14 2 increased oxygen consumption 0.00201716772168171 0.0342714639236127 1.13186419762491 0.418604651162791 14.2 14 2 improved glucose tolerance 4.83878246645176e-06 0.00029003545506744 1.13122255125437 0.418367346938776 14.2 14 2 abnormal joint morphology 0.0122851597786055 0.125752416387348 1.13072090045559 0.418181818181818 14.2 14 2 abnormal nervous system morphology 0.00315692797934672 0.0468827364097012 1.1294762984738 0.417721518987342 14.2 14 2 abnormal testis morphology 0.000437556426751086 0.0122985492829754 1.12858343183469 0.417391304347826 14.2 14 2 hydronephrosis 0.00253625864147471 0.0403127371927689 1.12662408559886 0.416666666666667 14.2 14 2 enlarged spleen 4.76015199871451e-08 6.07224517784736e-06 1.12662408559886 0.416666666666667 14.2 14 2 abnormal digit morphology 0.00495661630968433 0.0648925424754725 1.12662408559886 0.416666666666667 14.2 14 2 abnormal adrenal gland morphology 0.0860560693846246 0.380559062389784 1.12662408559886 0.416666666666667 14.2 14 2 ocular hypertelorism 0.0860560693846246 0.380559062389784 1.12662408559886 0.416666666666667 14.2 14 2 abnormal cardiac muscle contractility 0.0860560693846246 0.380559062389784 1.12662408559886 0.416666666666667 14.2 14 2 abnormal lung saccule morphology 0.0860560693846246 0.380559062389784 1.12662408559886 0.416666666666667 14.2 14 2 abnormal adipose tissue distribution 0.201527009201482 0.605161793547883 1.12662408559886 0.416666666666667 14.2 14 2 mesocardia 0.201527009201482 0.605161793547883 1.12662408559886 0.416666666666667 14.2 14 2 abnormal enteric nervous system morphology 0.201527009201482 0.605161793547883 1.12662408559886 0.416666666666667 14.2 14 2 abnormal mating frequency 0.201527009201482 0.605161793547883 1.12662408559886 0.416666666666667 14.2 14 2 abnormal thymus involution 0.201527009201482 0.605161793547883 1.12662408559886 0.416666666666667 14.2 14 2 increased growth rate 0.201527009201482 0.605161793547883 1.12662408559886 0.416666666666667 14.2 14 2 increased urine phosphate level 0.201527009201482 0.605161793547883 1.12662408559886 0.416666666666667 14.2 14 2 abnormal gastrocnemius morphology 0.201527009201482 0.605161793547883 1.12662408559886 0.416666666666667 14.2 14 2 abnormal alisphenoid bone morphology 0.201527009201482 0.605161793547883 1.12662408559886 0.416666666666667 14.2 14 2 increased osteosarcoma incidence 0.201527009201482 0.605161793547883 1.12662408559886 0.416666666666667 14.2 14 2 abnormal defecation 0.201527009201482 0.605161793547883 1.12662408559886 0.416666666666667 14.2 14 2 increased hepatocyte proliferation 0.201527009201482 0.605161793547883 1.12662408559886 0.416666666666667 14.2 14 2 pale placenta 0.201527009201482 0.605161793547883 1.12662408559886 0.416666666666667 14.2 14 2 vestibular saccular macula degeneration 0.201527009201482 0.605161793547883 1.12662408559886 0.416666666666667 14.2 14 2 bowed ulna 0.201527009201482 0.605161793547883 1.12662408559886 0.416666666666667 14.2 14 2 absent cochlear hair cells 0.201527009201482 0.605161793547883 1.12662408559886 0.416666666666667 14.2 14 2 hemoperitoneum 0.201527009201482 0.605161793547883 1.12662408559886 0.416666666666667 14.2 14 2 impaired behavioral response to cocaine 0.201527009201482 0.605161793547883 1.12662408559886 0.416666666666667 14.2 14 2 decreased red blood cell distribution width 0.201527009201482 0.605161793547883 1.12662408559886 0.416666666666667 14.2 14 2 increased fibrosarcoma incidence 0.201527009201482 0.605161793547883 1.12662408559886 0.416666666666667 14.2 14 2 abnormal pulmonary valve cusp morphology 0.201527009201482 0.605161793547883 1.12662408559886 0.416666666666667 14.2 14 2 increased type II pneumocyte number 0.201527009201482 0.605161793547883 1.12662408559886 0.416666666666667 14.2 14 2 prenatal growth retardation 0.201527009201482 0.605161793547883 1.12662408559886 0.416666666666667 14.2 14 2 abnormal respiratory motile cilium morphology 0.201527009201482 0.605161793547883 1.12662408559886 0.416666666666667 14.2 14 2 decreased body length 1.11281327521827e-07 1.23027689871353e-05 1.12497937890456 0.416058394160584 14.2 14 2 increased startle reflex 0.00203896957119202 0.0342714639236127 1.12409234608066 0.415730337078652 14.2 14 2 increased circulating cholesterol level 2.20862948559529e-05 0.0010365973293242 1.12150306702796 0.414772727272727 14.2 14 2 enlarged heart 1.42454686368305e-06 0.000101244580668902 1.11885426431887 0.413793103448276 14.2 14 2 dermatitis 0.0123722717429216 0.125752416387348 1.11885426431887 0.413793103448276 14.2 14 2 cochlear ganglion degeneration 0.0123722717429216 0.125752416387348 1.11885426431887 0.413793103448276 14.2 14 2 abnormal middle ear morphology 0.066359768959762 0.33687739854573 1.11885426431887 0.413793103448276 14.2 14 2 abnormal inner ear morphology 0.0249298458096058 0.192904858914957 1.11682735441974 0.41304347826087 14.2 14 2 thymus hypoplasia 0.000188634309271395 0.00621493833526615 1.11682735441974 0.41304347826087 14.2 14 2 abnormal vertebrae morphology 0.000856620453390586 0.019042930683466 1.11628808481355 0.412844036697248 14.2 14 2 increased bone mineral content 0.000856620453390586 0.019042930683466 1.11628808481355 0.412844036697248 14.2 14 2 abnormal myocardial fiber morphology 0.00165242314190469 0.029785525836869 1.11500940430403 0.412371134020619 14.2 14 2 decreased body size 1.05178108149754e-18 5.8140120893892e-16 1.11476488469782 0.412280701754386 14.2 14 2 thin skin 0.0515618200008652 0.297242241604061 1.11336968459182 0.411764705882353 14.2 14 2 absence seizures 0.148397878079107 0.52655711864879 1.11336968459182 0.411764705882353 14.2 14 2 aminoaciduria 0.148397878079107 0.52655711864879 1.11336968459182 0.411764705882353 14.2 14 2 increased regulatory T cell number 0.148397878079107 0.52655711864879 1.11336968459182 0.411764705882353 14.2 14 2 decreased growth hormone level 0.148397878079107 0.52655711864879 1.11336968459182 0.411764705882353 14.2 14 2 pancytopenia 0.148397878079107 0.52655711864879 1.11336968459182 0.411764705882353 14.2 14 2 abnormal electroretinogram waveform feature 0.148397878079107 0.52655711864879 1.11336968459182 0.411764705882353 14.2 14 2 abnormal ductus venosus valve morphology 0.148397878079107 0.52655711864879 1.11336968459182 0.411764705882353 14.2 14 2 decreased body fat mass 0.148397878079107 0.52655711864879 1.11336968459182 0.411764705882353 14.2 14 2 distended abdomen 0.0197097486377936 0.163699498285514 1.11336968459182 0.411764705882353 14.2 14 2 abnormal cervical vertebrae morphology 0.0197097486377936 0.163699498285514 1.11336968459182 0.411764705882353 14.2 14 2 increased circulating glucose level 0.000189973865528954 0.00621789461188517 1.11224165046356 0.411347517730496 14.2 14 2 double outlet right ventricle 0.00107006654329623 0.0221815877204115 1.11188320971252 0.411214953271028 14.2 14 2 infertility 0.00107006654329623 0.0221815877204115 1.11188320971252 0.411214953271028 14.2 14 2 abnormal spatial learning 6.5363524303441e-05 0.00264376856430585 1.11141811634538 0.411042944785276 14.2 14 2 alopecia 0.00206662094011735 0.0342714639236127 1.11002120433741 0.410526315789474 14.2 14 2 impaired righting response 0.00206662094011735 0.0342714639236127 1.11002120433741 0.410526315789474 14.2 14 2 reduced fertility 0.000236440923437538 0.00735735749677827 1.10879262525126 0.410071942446043 14.2 14 2 increased double-negative T cell number 0.0124109419992338 0.125752416387348 1.10815483829396 0.409836065573771 14.2 14 2 decreased body weight 1.946022610353e-27 3.22715416216873e-24 1.10733133065969 0.409531502423263 14.2 14 2 abnormal motor capabilities/coordination/movement 0.000364324371747319 0.010537870636296 1.10614001131525 0.409090909090909 14.2 14 2 hypertension 0.0316378432358418 0.224214059969107 1.10614001131525 0.409090909090909 14.2 14 2 abnormal astrocyte morphology 0.0316378432358418 0.224214059969107 1.10614001131525 0.409090909090909 14.2 14 2 lethality, incomplete penetrance 0.0316378432358418 0.224214059969107 1.10614001131525 0.409090909090909 14.2 14 2 intestinal ulcer 0.111813302360502 0.448469571359015 1.10614001131525 0.409090909090909 14.2 14 2 abnormal channel response 0.111813302360502 0.448469571359015 1.10614001131525 0.409090909090909 14.2 14 2 abnormal limb posture 0.111813302360502 0.448469571359015 1.10614001131525 0.409090909090909 14.2 14 2 abnormal temporal bone morphology 0.111813302360502 0.448469571359015 1.10614001131525 0.409090909090909 14.2 14 2 increased bone volume 0.111813302360502 0.448469571359015 1.10614001131525 0.409090909090909 14.2 14 2 hydroencephaly 0.000865365730258487 0.0191341978134932 1.1050712770048 0.408695652173913 14.2 14 2 increased or absent threshold for auditory brainstem response 2.24220340700142e-07 2.18724744114354e-05 1.10401363682214 0.408304498269896 14.2 14 2 organ of Corti degeneration 0.0249322259863955 0.192904858914957 1.10363175732134 0.408163265306122 14.2 14 2 abnormal long bone hypertrophic chondrocyte zone 0.0249322259863955 0.192904858914957 1.10363175732134 0.408163265306122 14.2 14 2 absent kidney 0.0249322259863955 0.192904858914957 1.10363175732134 0.408163265306122 14.2 14 2 abnormal heart valve morphology 0.0854630635588421 0.380559062389784 1.10158799480778 0.407407407407407 14.2 14 2 abnormal atrioventricular cushion morphology 0.0854630635588421 0.380559062389784 1.10158799480778 0.407407407407407 14.2 14 2 rectal prolapse 0.0854630635588421 0.380559062389784 1.10158799480778 0.407407407407407 14.2 14 2 thin epidermis 0.0854630635588421 0.380559062389784 1.10158799480778 0.407407407407407 14.2 14 2 thick interventricular septum 0.0854630635588421 0.380559062389784 1.10158799480778 0.407407407407407 14.2 14 2 increased leukocyte cell number 0.000238097398388201 0.00735735749677827 1.10020669324689 0.406896551724138 14.2 14 2 postnatal lethality, incomplete penetrance 8.10995990265454e-13 2.12352897451086e-10 1.09964857932396 0.40669014084507 14.2 14 2 decreased anxiety-related response 0.000698593109118236 0.0167898585404021 1.09914544936475 0.40650406504065 14.2 14 2 retinal degeneration 0.0025857244834674 0.04045276511085 1.09845848345889 0.40625 14.2 14 2 increased sacral vertebrae number 0.0124074311634605 0.125752416387348 1.09845848345889 0.40625 14.2 14 2 scoliosis 0.0659716794362286 0.3367822805716 1.09845848345889 0.40625 14.2 14 2 abnormal lymphatic vessel morphology 0.0659716794362286 0.3367822805716 1.09845848345889 0.40625 14.2 14 2 increased fatty acid level 0.0659716794362286 0.3367822805716 1.09845848345889 0.40625 14.2 14 2 abnormal food intake 0.00987449530469058 0.107495873393513 1.0972338920615 0.405797101449275 14.2 14 2 increased brown adipose tissue amount 0.0512977988503034 0.296751801488674 1.09617478598808 0.405405405405405 14.2 14 2 abnormal long bone metaphysis morphology 0.0512977988503034 0.296751801488674 1.09617478598808 0.405405405405405 14.2 14 2 increased circulating phosphate level 0.0512977988503034 0.296751801488674 1.09617478598808 0.405405405405405 14.2 14 2 abnormal visceral yolk sac morphology 0.00628472874213677 0.0770111465323409 1.09524974397459 0.40506329113924 14.2 14 2 abnormal muscle morphology 0.0401120213708109 0.258829191076244 1.09443482601033 0.404761904761905 14.2 14 2 impaired coordination 3.45935058513179e-08 4.52901820027123e-06 1.09406269584167 0.404624277456647 14.2 14 2 abnormal cell nucleus morphology 0.0315055591650604 0.224214059969107 1.09306507028315 0.404255319148936 14.2 14 2 increased respiratory quotient 0.0315055591650604 0.224214059969107 1.09306507028315 0.404255319148936 14.2 14 2 decreased bone trabecula number 0.0315055591650604 0.224214059969107 1.09306507028315 0.404255319148936 14.2 14 2 cachexia 0.00207391543202825 0.0342781703466464 1.0919587291189 0.403846153846154 14.2 14 2 abnormal skin condition 0.0248358885748109 0.192904858914957 1.0919587291189 0.403846153846154 14.2 14 2 kinked neural tube 0.0248358885748109 0.192904858914957 1.0919587291189 0.403846153846154 14.2 14 2 abnormal brain wave pattern 0.0248358885748109 0.192904858914957 1.0919587291189 0.403846153846154 14.2 14 2 pericardial effusion 0.0155669981260453 0.146306524353899 1.09028137316019 0.403225806451613 14.2 14 2 rib fusion 0.0123673061385174 0.125752416387348 1.08963045890756 0.402985074626866 14.2 14 2 internal hemorrhage 0.0123673061385174 0.125752416387348 1.08963045890756 0.402985074626866 14.2 14 2 increased heart weight 0.000453530061782437 0.0124658124716443 1.08934012305387 0.402877697841727 14.2 14 2 abnormal heart left ventricle morphology 0.00984396484565316 0.107398519971764 1.08906994941224 0.402777777777778 14.2 14 2 polyuria 0.00784849165913766 0.0903848287134487 1.08858223335786 0.402597402597403 14.2 14 2 female infertility 1.84025575922757e-06 0.000125414690440509 1.08765813978116 0.402255639097744 14.2 14 2 kinked tail 0.00257710976412323 0.04045276511085 1.08686088257773 0.401960784313726 14.2 14 2 increased circulating insulin level 0.000236818852204101 0.00735735749677827 1.08155912217491 0.4 14.2 14 2 abnormal posture 0.007807612068175 0.0901226683043402 1.08155912217491 0.4 14.2 14 2 intracranial hemorrhage 0.0195072668155539 0.163699498285514 1.08155912217491 0.4 14.2 14 2 abnormal head morphology 0.0246576887090354 0.192880505231841 1.08155912217491 0.4 14.2 14 2 abnormal learning/memory/conditioning 0.0246576887090354 0.192880505231841 1.08155912217491 0.4 14.2 14 2 abnormal circulating protein level 0.0312585512928323 0.224214059969107 1.08155912217491 0.4 14.2 14 2 increased circulating serum albumin level 0.0652356519439053 0.3367822805716 1.08155912217491 0.4 14.2 14 2 abnormal intestinal goblet cell morphology 0.0652356519439053 0.3367822805716 1.08155912217491 0.4 14.2 14 2 abnormal lactation 0.0843423915422116 0.379452868805688 1.08155912217491 0.4 14.2 14 2 abnormal inner ear vestibule morphology 0.110027145935233 0.448469571359015 1.08155912217491 0.4 14.2 14 2 increased pre-B cell number 0.110027145935233 0.448469571359015 1.08155912217491 0.4 14.2 14 2 decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 0.110027145935233 0.448469571359015 1.08155912217491 0.4 14.2 14 2 abnormal dopamine level 0.145352937862406 0.52655711864879 1.08155912217491 0.4 14.2 14 2 absent placental labyrinth 0.145352937862406 0.52655711864879 1.08155912217491 0.4 14.2 14 2 abnormal prostate gland morphology 0.195737519914958 0.605161793547883 1.08155912217491 0.4 14.2 14 2 hyperpigmentation 0.195737519914958 0.605161793547883 1.08155912217491 0.4 14.2 14 2 absent egg cylinders 0.195737519914958 0.605161793547883 1.08155912217491 0.4 14.2 14 2 abnormal cricoid cartilage morphology 0.195737519914958 0.605161793547883 1.08155912217491 0.4 14.2 14 2 arthritis 0.195737519914958 0.605161793547883 1.08155912217491 0.4 14.2 14 2 dilated ureter 0.195737519914958 0.605161793547883 1.08155912217491 0.4 14.2 14 2 decreased aggression towards males 0.195737519914958 0.605161793547883 1.08155912217491 0.4 14.2 14 2 abnormal placenta size 0.195737519914958 0.605161793547883 1.08155912217491 0.4 14.2 14 2 abnormal rostral migratory stream morphology 0.195737519914958 0.605161793547883 1.08155912217491 0.4 14.2 14 2 abnormal zygomatic bone morphology 0.195737519914958 0.605161793547883 1.08155912217491 0.4 14.2 14 2 abnormal cerebral aqueduct morphology 0.195737519914958 0.605161793547883 1.08155912217491 0.4 14.2 14 2 abnormal Muller cell morphology 0.195737519914958 0.605161793547883 1.08155912217491 0.4 14.2 14 2 bicuspid aortic valve 0.195737519914958 0.605161793547883 1.08155912217491 0.4 14.2 14 2 abnormal rib morphology 0.000694038278480345 0.016761361337086 1.08155912217491 0.4 14.2 14 2 abnormal cardiovascular system physiology 0.000857410346351033 0.019042930683466 1.07749311043741 0.398496240601504 14.2 14 2 increased spleen weight 0.00204849453570499 0.0342714639236127 1.07677346234228 0.398230088495575 14.2 14 2 cardiac hypertrophy 0.00396687853869026 0.0563863449428116 1.0760409633883 0.397959183673469 14.2 14 2 short femur 0.00619280636203718 0.0760721275336665 1.07541389988983 0.397727272727273 14.2 14 2 decreased hematocrit 0.000553317172778542 0.014337254867569 1.07415118298193 0.397260273972603 14.2 14 2 decreased bone marrow cell number 0.0121964013101835 0.125625458629737 1.07415118298193 0.397260273972603 14.2 14 2 decreased hemoglobin content 0.000686483823628758 0.0166597903539174 1.07388849010275 0.397163120567376 14.2 14 2 gliosis 0.0193273561628723 0.163699498285514 1.07297531961797 0.396825396825397 14.2 14 2 abnormal spleen morphology 0.000188204162588511 0.00621493833526615 1.07223533663892 0.396551724137931 14.2 14 2 small spleen 0.00613984158715525 0.0756081977626172 1.06967385709606 0.395604395604396 14.2 14 2 abnormal cranium morphology 0.00105030382980065 0.0219548804758749 1.06945211707594 0.395522388059701 14.2 14 2 increased total body fat amount 0.00105030382980065 0.0219548804758749 1.06945211707594 0.395522388059701 14.2 14 2 increased circulating creatinine level 0.00768170823196858 0.0894999963794934 1.06898285331241 0.395348837209302 14.2 14 2 abnormal blood circulation 0.0501180314151834 0.292993191880773 1.06898285331241 0.395348837209302 14.2 14 2 kidney failure 0.0501180314151834 0.292993191880773 1.06898285331241 0.395348837209302 14.2 14 2 persistence of hyaloid vascular system 0.0642442909797303 0.3367822805716 1.06732808109366 0.394736842105263 14.2 14 2 incomplete somite formation 0.0642442909797303 0.3367822805716 1.06732808109366 0.394736842105263 14.2 14 2 hyporesponsive to tactile stimuli 0.0642442909797303 0.3367822805716 1.06732808109366 0.394736842105263 14.2 14 2 abnormal ovary morphology 0.0151736808994509 0.144892634308577 1.06632589510202 0.394366197183099 14.2 14 2 abnormal CD4-positive, alpha-beta T cell physiology 0.0151736808994509 0.144892634308577 1.06632589510202 0.394366197183099 14.2 14 2 abnormal neuron morphology 0.00486588202488549 0.0642115731400671 1.06517186274802 0.393939393939394 14.2 14 2 abnormal skin morphology 0.0191059033499331 0.163699498285514 1.06517186274802 0.393939393939394 14.2 14 2 abnormal tooth development 0.0828565340370306 0.377482835928779 1.06517186274802 0.393939393939394 14.2 14 2 decreased systemic arterial blood pressure 0.0828565340370306 0.377482835928779 1.06517186274802 0.393939393939394 14.2 14 2 dilated heart atrium 0.0828565340370306 0.377482835928779 1.06517186274802 0.393939393939394 14.2 14 2 single kidney 0.0828565340370306 0.377482835928779 1.06517186274802 0.393939393939394 14.2 14 2 abnormal QRS complex 0.0828565340370306 0.377482835928779 1.06517186274802 0.393939393939394 14.2 14 2 abnormal circulating cholesterol level 0.107715625388823 0.445087405572585 1.06224556642179 0.392857142857143 14.2 14 2 abnormal retinal inner nuclear layer morphology 0.107715625388823 0.445087405572585 1.06224556642179 0.392857142857143 14.2 14 2 abnormal hormone level 0.107715625388823 0.445087405572585 1.06224556642179 0.392857142857143 14.2 14 2 increased T cell proliferation 0.00385843759202254 0.0550020831527569 1.0613430638165 0.392523364485981 14.2 14 2 decreased B cell proliferation 0.0119313091726542 0.123462097243495 1.06102318947539 0.392405063291139 14.2 14 2 reduced female fertility 3.28313718615162e-05 0.0014848734091913 1.06058060471893 0.392241379310345 14.2 14 2 postnatal growth retardation 2.37107430958082e-11 5.36186122280209e-09 1.06035208056364 0.392156862745098 14.2 14 2 increased kidney weight 0.0387093917154381 0.252728640136882 1.06035208056364 0.392156862745098 14.2 14 2 abnormal skeleton morphology 0.0030613407501591 0.0460648387847768 1.05804696734502 0.391304347826087 14.2 14 2 abnormal forelimb morphology 0.0493004854612953 0.290948891067549 1.05804696734502 0.391304347826087 14.2 14 2 abnormal sleep pattern 0.0493004854612953 0.290948891067549 1.05804696734502 0.391304347826087 14.2 14 2 atrial septal defect 0.0493004854612953 0.290948891067549 1.05804696734502 0.391304347826087 14.2 14 2 fragile skeleton 0.141562865495664 0.520667383442438 1.05804696734502 0.391304347826087 14.2 14 2 abnormal pulmonary artery morphology 0.141562865495664 0.520667383442438 1.05804696734502 0.391304347826087 14.2 14 2 abnormal nasal cavity morphology 0.141562865495664 0.520667383442438 1.05804696734502 0.391304347826087 14.2 14 2 abnormal basicranium morphology 0.141562865495664 0.520667383442438 1.05804696734502 0.391304347826087 14.2 14 2 abnormal vertebral artery topology 0.141562865495664 0.520667383442438 1.05804696734502 0.391304347826087 14.2 14 2 respiratory failure 0.000813524402127043 0.0188245762817769 1.05648987099867 0.390728476821192 14.2 14 2 abnormal lens morphology 0.00195470311584134 0.0337661388934398 1.05621008024894 0.390625 14.2 14 2 perinatal lethality, complete penetrance 9.23370940802107e-05 0.00340279291147443 1.05363153920795 0.389671361502347 14.2 14 2 abnormal neuromuscular synapse morphology 0.0185653183882314 0.163699498285514 1.05151581322561 0.388888888888889 14.2 14 2 abnormal chondrocyte morphology 0.0380521901538764 0.249091639494125 1.05151581322561 0.388888888888889 14.2 14 2 increased cell proliferation 0.0380521901538764 0.249091639494125 1.05151581322561 0.388888888888889 14.2 14 2 decreased tumor growth/size 0.0380521901538764 0.249091639494125 1.05151581322561 0.388888888888889 14.2 14 2 abnormal osteoblast physiology 0.0380521901538764 0.249091639494125 1.05151581322561 0.388888888888889 14.2 14 2 abnormal reflex 0.0811191719597195 0.373462505284808 1.05151581322561 0.388888888888889 14.2 14 2 abnormal retinal blood vessel morphology 0.0811191719597195 0.373462505284808 1.05151581322561 0.388888888888889 14.2 14 2 abnormal megakaryocyte differentiation 0.1890057078382 0.60083284121089 1.05151581322561 0.388888888888889 14.2 14 2 underdeveloped hair follicles 0.1890057078382 0.60083284121089 1.05151581322561 0.388888888888889 14.2 14 2 abnormal thyroid cartilage morphology 0.1890057078382 0.60083284121089 1.05151581322561 0.388888888888889 14.2 14 2 abnormal Peyer's patch follicle morphology 0.1890057078382 0.60083284121089 1.05151581322561 0.388888888888889 14.2 14 2 absent allantois 0.1890057078382 0.60083284121089 1.05151581322561 0.388888888888889 14.2 14 2 abnormal redox activity 0.1890057078382 0.60083284121089 1.05151581322561 0.388888888888889 14.2 14 2 decreased cellular sensitivity to gamma-irradiation 0.1890057078382 0.60083284121089 1.05151581322561 0.388888888888889 14.2 14 2 increased circulating glycerol level 0.1890057078382 0.60083284121089 1.05151581322561 0.388888888888889 14.2 14 2 decreased activity of thyroid 0.1890057078382 0.60083284121089 1.05151581322561 0.388888888888889 14.2 14 2 atrioventricular block 0.1890057078382 0.60083284121089 1.05151581322561 0.388888888888889 14.2 14 2 increased effector memory CD4-positive, alpha-beta T cell number 0.1890057078382 0.60083284121089 1.05151581322561 0.388888888888889 14.2 14 2 decreased fluid intake 0.1890057078382 0.60083284121089 1.05151581322561 0.388888888888889 14.2 14 2 abnormal hypoglossal nerve topology 0.1890057078382 0.60083284121089 1.05151581322561 0.388888888888889 14.2 14 2 postnatal lethality, complete penetrance 2.31971740678228e-07 2.21934501898882e-05 1.05073748915956 0.38860103626943 14.2 14 2 circling 0.0115978803273394 0.122764797081943 1.049748559758 0.388235294117647 14.2 14 2 maternal effect 0.023379160118148 0.184914660711902 1.04927377524432 0.388059701492537 14.2 14 2 increased fluid intake 0.0483790826336104 0.290948891067549 1.04845016945527 0.387755102040816 14.2 14 2 lethargy 0.00912261514483897 0.103147750785395 1.04667011823378 0.387096774193548 14.2 14 2 osteopetrosis 0.105073399407967 0.435616801712197 1.04667011823378 0.387096774193548 14.2 14 2 inner cell mass degeneration 0.105073399407967 0.435616801712197 1.04667011823378 0.387096774193548 14.2 14 2 decreased neuronal precursor cell number 0.105073399407967 0.435616801712197 1.04667011823378 0.387096774193548 14.2 14 2 decreased double-negative T cell number 0.105073399407967 0.435616801712197 1.04667011823378 0.387096774193548 14.2 14 2 delayed bone ossification 0.0182573689692249 0.161908040324231 1.04550715143575 0.386666666666667 14.2 14 2 abnormal circadian rhythm 0.0617537054540283 0.333625488080865 1.0446877884644 0.386363636363636 14.2 14 2 omphalocele 0.0617537054540283 0.333625488080865 1.0446877884644 0.386363636363636 14.2 14 2 renal interstitial fibrosis 0.0617537054540283 0.333625488080865 1.0446877884644 0.386363636363636 14.2 14 2 abnormal amino acid level 0.0617537054540283 0.333625488080865 1.0446877884644 0.386363636363636 14.2 14 2 increased blood urea nitrogen level 0.00149119255870447 0.0281951195231278 1.04426398003095 0.386206896551724 14.2 14 2 abnormal cell morphology 0.00455216427899877 0.061374030590837 1.04360967929158 0.385964912280702 14.2 14 2 decreased birth body size 0.00455216427899877 0.061374030590837 1.04360967929158 0.385964912280702 14.2 14 2 abnormal craniofacial bone morphology 0.0373338579760232 0.247780930160264 1.04360967929158 0.385964912280702 14.2 14 2 decreased brain weight 0.0373338579760232 0.247780930160264 1.04360967929158 0.385964912280702 14.2 14 2 short tail 0.0142943528185954 0.140265099156829 1.04246662378305 0.385542168674699 14.2 14 2 abnormal lipid level 0.0142943528185954 0.140265099156829 1.04246662378305 0.385542168674699 14.2 14 2 abnormal heart morphology 8.52980642211608e-05 0.00321483234469905 1.04176149213817 0.385281385281385 14.2 14 2 increased B cell number 0.00447845802979898 0.0607093425020434 1.03996069439895 0.384615384615385 14.2 14 2 abnormal B cell differentiation 0.0112162664799774 0.120001990834167 1.03996069439895 0.384615384615385 14.2 14 2 absent corpus luteum 0.0473803311783298 0.290948891067549 1.03996069439895 0.384615384615385 14.2 14 2 abnormal xiphoid process morphology 0.137373276380985 0.516577513224038 1.03996069439895 0.384615384615385 14.2 14 2 thick skin 0.137373276380985 0.516577513224038 1.03996069439895 0.384615384615385 14.2 14 2 no spontaneous movement 0.137373276380985 0.516577513224038 1.03996069439895 0.384615384615385 14.2 14 2 abnormal erythrocyte osmotic lysis 0.137373276380985 0.516577513224038 1.03996069439895 0.384615384615385 14.2 14 2 increased thymocyte apoptosis 0.137373276380985 0.516577513224038 1.03996069439895 0.384615384615385 14.2 14 2 short hair 0.258805794035676 0.634433926155609 1.03996069439895 0.384615384615385 14.2 14 2 pup cannibalization 0.258805794035676 0.634433926155609 1.03996069439895 0.384615384615385 14.2 14 2 abnormal pulmonary alveolus epithelial cell morphology 0.258805794035676 0.634433926155609 1.03996069439895 0.384615384615385 14.2 14 2 dystrophic cardiac calcinosis 0.258805794035676 0.634433926155609 1.03996069439895 0.384615384615385 14.2 14 2 abnormal tail bud morphology 0.258805794035676 0.634433926155609 1.03996069439895 0.384615384615385 14.2 14 2 increased synaptic depression 0.258805794035676 0.634433926155609 1.03996069439895 0.384615384615385 14.2 14 2 abnormal coping response 0.258805794035676 0.634433926155609 1.03996069439895 0.384615384615385 14.2 14 2 abnormal telomere length 0.258805794035676 0.634433926155609 1.03996069439895 0.384615384615385 14.2 14 2 abnormal dopaminergic neuron morphology 0.258805794035676 0.634433926155609 1.03996069439895 0.384615384615385 14.2 14 2 decreased alcohol consumption 0.258805794035676 0.634433926155609 1.03996069439895 0.384615384615385 14.2 14 2 vestibular hair cell degeneration 0.258805794035676 0.634433926155609 1.03996069439895 0.384615384615385 14.2 14 2 increased cochlear inner hair cell number 0.258805794035676 0.634433926155609 1.03996069439895 0.384615384615385 14.2 14 2 decreased endocochlear potential 0.258805794035676 0.634433926155609 1.03996069439895 0.384615384615385 14.2 14 2 increased circulating thyroxine level 0.258805794035676 0.634433926155609 1.03996069439895 0.384615384615385 14.2 14 2 abnormal hair follicle inner root sheath morphology 0.258805794035676 0.634433926155609 1.03996069439895 0.384615384615385 14.2 14 2 decreased cardiac stroke volume 0.258805794035676 0.634433926155609 1.03996069439895 0.384615384615385 14.2 14 2 abnormal coat/hair pigmentation 0.00557439527497467 0.0704749304385699 1.03810362173038 0.383928571428571 14.2 14 2 abnormal long bone epiphyseal plate morphology 0.0365690794425142 0.247780930160264 1.03649415875096 0.383333333333333 14.2 14 2 muscular ventricular septal defect 0.0365690794425142 0.247780930160264 1.03649415875096 0.383333333333333 14.2 14 2 neuron degeneration 0.0603456121279238 0.333625488080865 1.03553532974193 0.382978723404255 14.2 14 2 hyperactivity 1.30275992671405e-06 9.47631893831368e-05 1.03491506299756 0.382749326145553 14.2 14 2 increased exploration in new environment 0.0175885570202728 0.161410754014792 1.03482508603155 0.382716049382716 14.2 14 2 abnormal spleen red pulp morphology 0.102229452249895 0.431075338652721 1.03384327854955 0.382352941176471 14.2 14 2 increased susceptibility to weight gain 0.102229452249895 0.431075338652721 1.03384327854955 0.382352941176471 14.2 14 2 impaired balance 0.00865676200222668 0.0987784196354994 1.03384327854955 0.382352941176471 14.2 14 2 abnormal muscle physiology 0.0137683370135915 0.135638567609144 1.03294972342548 0.382022471910112 14.2 14 2 decreased circulating calcium level 0.0463252645756899 0.290948891067549 1.03239734389423 0.381818181818182 14.2 14 2 abnormal contextual conditioning behavior 0.0463252645756899 0.290948891067549 1.03239734389423 0.381818181818182 14.2 14 2 increased food intake 0.0172348571945056 0.159374376473355 1.03005630683325 0.380952380952381 14.2 14 2 skin edema 0.0771921517791492 0.356243928665368 1.03005630683325 0.380952380952381 14.2 14 2 abnormal reproductive system morphology 0.0771921517791492 0.356243928665368 1.03005630683325 0.380952380952381 14.2 14 2 increased vasoconstriction 0.181949579825041 0.586648839682163 1.03005630683325 0.380952380952381 14.2 14 2 absent segment of posterior cerebral artery 0.181949579825041 0.586648839682163 1.03005630683325 0.380952380952381 14.2 14 2 decreased vocalization 0.181949579825041 0.586648839682163 1.03005630683325 0.380952380952381 14.2 14 2 decreased double-positive T cell number 0.0105868220044344 0.113511723000132 1.02748116606616 0.38 14.2 14 2 decreased heart rate 0.0105868220044344 0.113511723000132 1.02748116606616 0.38 14.2 14 2 kidney inflammation 0.0588723115198941 0.332829261149401 1.02748116606616 0.38 14.2 14 2 abnormal axon extension 0.0588723115198941 0.332829261149401 1.02748116606616 0.38 14.2 14 2 hypoactivity 2.14438250830402e-06 0.0001422440397175 1.02561640895897 0.379310344827586 14.2 14 2 abnormal blood vessel morphology 0.00260447915443203 0.0406184444931014 1.02561640895897 0.379310344827586 14.2 14 2 abnormal enzyme/coenzyme level 0.0452306546875163 0.287018503916319 1.02561640895897 0.379310344827586 14.2 14 2 thrombocytosis 0.0452306546875163 0.287018503916319 1.02561640895897 0.379310344827586 14.2 14 2 abnormal microglial cell morphology 0.132988648762137 0.502367902499341 1.02561640895897 0.379310344827586 14.2 14 2 decreased retinal photoreceptor cell number 0.132988648762137 0.502367902499341 1.02561640895897 0.379310344827586 14.2 14 2 abnormal CD8-positive, alpha-beta T cell physiology 0.132988648762137 0.502367902499341 1.02561640895897 0.379310344827586 14.2 14 2 decreased circulating chloride level 0.0992713121132772 0.423926847865712 1.02309646692221 0.378378378378378 14.2 14 2 decreased width of hypertrophic chondrocyte zone 0.0992713121132772 0.423926847865712 1.02309646692221 0.378378378378378 14.2 14 2 abnormal calcium ion homeostasis 0.0992713121132772 0.423926847865712 1.02309646692221 0.378378378378378 14.2 14 2 skin inflammation 0.0992713121132772 0.423926847865712 1.02309646692221 0.378378378378378 14.2 14 2 abnormal humerus morphology 0.0992713121132772 0.423926847865712 1.02309646692221 0.378378378378378 14.2 14 2 abnormal respiratory electron transport chain 0.0992713121132772 0.423926847865712 1.02309646692221 0.378378378378378 14.2 14 2 small placenta 0.0751045080687286 0.351374751549671 1.0214725042763 0.377777777777778 14.2 14 2 polydactyly 0.0129258518888227 0.129388557639624 1.02085937552224 0.377551020408163 14.2 14 2 abnormal sternum morphology 0.0341057407954003 0.24067526305974 1.01886004262854 0.376811594202899 14.2 14 2 abnormal retina morphology 0.000487043974499549 0.013313427324919 1.01718060299783 0.376190476190476 14.2 14 2 decreased neutrophil cell number 0.00780480631076288 0.0901226683043402 1.01685045674564 0.376068376068376 14.2 14 2 decreased startle reflex 0.00780480631076288 0.0901226683043402 1.01685045674564 0.376068376068376 14.2 14 2 neonatal lethality, complete penetrance 5.44474763611771e-07 4.28693098901731e-05 1.01396167703898 0.375 14.2 14 2 decreased cardiac muscle contractility 0.0123478092505141 0.125752416387348 1.01396167703898 0.375 14.2 14 2 thymus atrophy 0.0729805127995782 0.342849906683571 1.01396167703898 0.375 14.2 14 2 decreased metastatic potential 0.174866943162288 0.579638409541588 1.01396167703898 0.375 14.2 14 2 abnormal tumor morphology 0.174866943162288 0.579638409541588 1.01396167703898 0.375 14.2 14 2 abnormal inner cell mass apoptosis 0.174866943162288 0.579638409541588 1.01396167703898 0.375 14.2 14 2 decreased eosinophil cell number 0.0429738566418947 0.273395059838141 1.01396167703898 0.375 14.2 14 2 increased circulating follicle stimulating hormone level 0.12853443139101 0.487764146582971 1.01396167703898 0.375 14.2 14 2 bradykinesia 0.12853443139101 0.487764146582971 1.01396167703898 0.375 14.2 14 2 delayed hair appearance 0.245735212158304 0.634433926155609 1.01396167703898 0.375 14.2 14 2 reduced male mating frequency 0.245735212158304 0.634433926155609 1.01396167703898 0.375 14.2 14 2 disorganized yolk sac vascular plexus 0.245735212158304 0.634433926155609 1.01396167703898 0.375 14.2 14 2 abnormal extraembryonic endoderm formation 0.245735212158304 0.634433926155609 1.01396167703898 0.375 14.2 14 2 abnormal olfaction 0.245735212158304 0.634433926155609 1.01396167703898 0.375 14.2 14 2 impaired muscle relaxation 0.245735212158304 0.634433926155609 1.01396167703898 0.375 14.2 14 2 large intestinal inflammation 0.245735212158304 0.634433926155609 1.01396167703898 0.375 14.2 14 2 bowed radius 0.245735212158304 0.634433926155609 1.01396167703898 0.375 14.2 14 2 small epididymis 0.245735212158304 0.634433926155609 1.01396167703898 0.375 14.2 14 2 abnormal amnion morphology 0.245735212158304 0.634433926155609 1.01396167703898 0.375 14.2 14 2 abnormal level of surface class II molecules 0.245735212158304 0.634433926155609 1.01396167703898 0.375 14.2 14 2 decreased circulating prolactin level 0.245735212158304 0.634433926155609 1.01396167703898 0.375 14.2 14 2 impaired behavioral response to addictive substance 0.245735212158304 0.634433926155609 1.01396167703898 0.375 14.2 14 2 small ovary 0.0196568690153025 0.163699498285514 1.01024753170184 0.373626373626374 14.2 14 2 abnormal locomotor activation 0.0196568690153025 0.163699498285514 1.01024753170184 0.373626373626374 14.2 14 2 abnormal neurocranium morphology 0.032401048987735 0.229296185937385 1.00945518069658 0.373333333333333 14.2 14 2 increased circulating triglyceride level 0.00442797798218246 0.0601890449763873 1.00696883788699 0.372413793103448 14.2 14 2 decreased leukocyte cell number 0.00560704535498157 0.0704749304385699 1.00656049691461 0.372262773722628 14.2 14 2 absent gastric milk in neonates 0.0315466528132015 0.224214059969107 1.00529533791899 0.371794871794872 14.2 14 2 abnormal hippocampus pyramidal cell morphology 0.12408942515798 0.478546246660299 1.00430489916242 0.371428571428571 14.2 14 2 no abnormal phenotype detected 2.13536704702296e-21 1.51763586556275e-18 1.00363699521706 0.371181556195965 14.2 14 2 abnormal mandible morphology 0.0687129879071127 0.342732121070729 1.00144363164344 0.37037037037037 14.2 14 2 abnormal type II pneumocyte morphology 0.167908695688128 0.579638409541588 1.00144363164344 0.37037037037037 14.2 14 2 abnormal skin appearance 0.167908695688128 0.579638409541588 1.00144363164344 0.37037037037037 14.2 14 2 enlarged liver 0.018190953169228 0.161607128601623 1.00044218801179 0.37 14.2 14 2 delayed wound healing 0.090231004079983 0.389323542877966 0.999266580270297 0.369565217391304 14.2 14 2 decreased B cell number 0.001169890573168 0.0238696584139779 0.997554530161325 0.368932038834951 14.2 14 2 abnormal facial morphology 0.0666007450659925 0.337756072072694 0.996172875687417 0.368421052631579 14.2 14 2 decreased hair follicle number 0.119703741107846 0.47376778998531 0.996172875687417 0.368421052631579 14.2 14 2 decreased total retina thickness 0.119703741107846 0.47376778998531 0.996172875687417 0.368421052631579 14.2 14 2 flaky skin 0.233475988224705 0.634433926155609 0.996172875687417 0.368421052631579 14.2 14 2 short vibrissae 0.233475988224705 0.634433926155609 0.996172875687417 0.368421052631579 14.2 14 2 abnormal stationary movement 0.233475988224705 0.634433926155609 0.996172875687417 0.368421052631579 14.2 14 2 decreased chemically-elicited antinociception 0.233475988224705 0.634433926155609 0.996172875687417 0.368421052631579 14.2 14 2 abnormal metatarsal bone morphology 0.233475988224705 0.634433926155609 0.996172875687417 0.368421052631579 14.2 14 2 maternal imprinting 0.233475988224705 0.634433926155609 0.996172875687417 0.368421052631579 14.2 14 2 oliguria 0.233475988224705 0.634433926155609 0.996172875687417 0.368421052631579 14.2 14 2 increased left ventricle weight 0.233475988224705 0.634433926155609 0.996172875687417 0.368421052631579 14.2 14 2 abnormal sternebra morphology 0.233475988224705 0.634433926155609 0.996172875687417 0.368421052631579 14.2 14 2 abnormal cochlear inner hair cell morphology 0.233475988224705 0.634433926155609 0.996172875687417 0.368421052631579 14.2 14 2 abnormal behavioral response to xenobiotic 0.233475988224705 0.634433926155609 0.996172875687417 0.368421052631579 14.2 14 2 increased liver cholesterol level 0.233475988224705 0.634433926155609 0.996172875687417 0.368421052631579 14.2 14 2 increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 0.233475988224705 0.634433926155609 0.996172875687417 0.368421052631579 14.2 14 2 decreased susceptibility to weight gain 0.233475988224705 0.634433926155609 0.996172875687417 0.368421052631579 14.2 14 2 decreased urine osmolality 0.087265214186269 0.385563446338089 0.993268581589203 0.36734693877551 14.2 14 2 perinatal lethality, incomplete penetrance 0.000842283009611948 0.0189780382485429 0.993024415271212 0.367256637168142 14.2 14 2 increased anxiety-related response 0.00773445660530824 0.0899040224565619 0.992077612066914 0.366906474820144 14.2 14 2 abnormal incisor morphology 0.0645173394400602 0.3367822805716 0.991429195327001 0.366666666666667 14.2 14 2 abnormal hair cycle 0.161152271363147 0.561371690456782 0.991429195327001 0.366666666666667 14.2 14 2 abnormal synaptic transmission 0.161152271363147 0.561371690456782 0.991429195327001 0.366666666666667 14.2 14 2 liver hemorrhage 0.161152271363147 0.561371690456782 0.991429195327001 0.366666666666667 14.2 14 2 atelectasis 0.0481662043589235 0.290948891067549 0.990159759737594 0.366197183098592 14.2 14 2 corneal opacity 0.0481662043589235 0.290948891067549 0.990159759737594 0.366197183098592 14.2 14 2 microphthalmia 0.00579051995521939 0.0722000921734749 0.989661941859395 0.366013071895425 14.2 14 2 Leydig cell hyperplasia 0.115409264063942 0.45786370711173 0.989230904428271 0.365853658536585 14.2 14 2 abnormal hair growth 0.0843534562305699 0.379452868805688 0.987962659679004 0.365384615384615 14.2 14 2 decreased kidney weight 0.0843534562305699 0.379452868805688 0.987962659679004 0.365384615384615 14.2 14 2 abnormal hair follicle morphology 0.0624702178346697 0.333625488080865 0.987137294048529 0.365079365079365 14.2 14 2 increased granulocyte number 0.04669349681301 0.290948891067549 0.986557307389276 0.364864864864865 14.2 14 2 cyanosis 0.00251995407148475 0.0401819599539635 0.985796074899006 0.364583333333333 14.2 14 2 increased sensitivity to xenobiotic induced morbidity/mortality 0.0196220493586155 0.163699498285514 0.983235565613555 0.363636363636364 14.2 14 2 increased liver weight 0.0340864569320393 0.24067526305974 0.983235565613555 0.363636363636364 14.2 14 2 abnormal rostral-caudal axis patterning 0.0815059726679252 0.373462505284808 0.983235565613555 0.363636363636364 14.2 14 2 decreased sensitivity to induced morbidity/mortality 0.111226000388519 0.448469571359015 0.983235565613555 0.363636363636364 14.2 14 2 embryonic lethality, incomplete penetrance 0.111226000388519 0.448469571359015 0.983235565613555 0.363636363636364 14.2 14 2 enlarged pericardium 0.154636087021855 0.541008813596154 0.983235565613555 0.363636363636364 14.2 14 2 dextrocardia 0.154636087021855 0.541008813596154 0.983235565613555 0.363636363636364 14.2 14 2 increased osteoblast cell number 0.154636087021855 0.541008813596154 0.983235565613555 0.363636363636364 14.2 14 2 cardiovascular system phenotype 0.154636087021855 0.541008813596154 0.983235565613555 0.363636363636364 14.2 14 2 intestinal inflammation 0.22202745266192 0.634433926155609 0.983235565613555 0.363636363636364 14.2 14 2 abnormal chorion morphology 0.22202745266192 0.634433926155609 0.983235565613555 0.363636363636364 14.2 14 2 increased coping response 0.22202745266192 0.634433926155609 0.983235565613555 0.363636363636364 14.2 14 2 abnormal cochlear sensory epithelium morphology 0.22202745266192 0.634433926155609 0.983235565613555 0.363636363636364 14.2 14 2 parakeratosis 0.22202745266192 0.634433926155609 0.983235565613555 0.363636363636364 14.2 14 2 prolonged PR interval 0.22202745266192 0.634433926155609 0.983235565613555 0.363636363636364 14.2 14 2 abnormal mesenteric lymph node morphology 0.22202745266192 0.634433926155609 0.983235565613555 0.363636363636364 14.2 14 2 rough coat 0.22202745266192 0.634433926155609 0.983235565613555 0.363636363636364 14.2 14 2 abnormal motor coordination/ balance 0.0258090373270828 0.199378820966206 0.983235565613554 0.363636363636364 14.2 14 2 increased bone mineral density 0.0190520340203 0.163699498285514 0.981060265689631 0.36283185840708 14.2 14 2 abnormal epidermal layer morphology 0.0585051747886074 0.331507112270298 0.979673117912056 0.36231884057971 14.2 14 2 perimembraneous ventricular septal defect 0.0585051747886074 0.331507112270298 0.979673117912056 0.36231884057971 14.2 14 2 cochlear outer hair cell degeneration 0.0565939483428398 0.321777020577861 0.976407540852349 0.361111111111111 14.2 14 2 head tilt 0.148376959574389 0.52655711864879 0.976407540852349 0.361111111111111 14.2 14 2 narrow eye opening 0.148376959574389 0.52655711864879 0.976407540852349 0.361111111111111 14.2 14 2 short stride length 0.103236221936105 0.431075338652721 0.973403209957419 0.36 14.2 14 2 decreased oocyte number 0.103236221936105 0.431075338652721 0.973403209957419 0.36 14.2 14 2 decreased respiratory quotient 0.103236221936105 0.431075338652721 0.973403209957419 0.36 14.2 14 2 abnormal thyroid gland morphology 0.211339329102507 0.6217700545742 0.973403209957419 0.36 14.2 14 2 abnormal energy expenditure 0.211339329102507 0.6217700545742 0.973403209957419 0.36 14.2 14 2 impaired macrophage chemotaxis 0.142379432046495 0.520667383442438 0.970629981439022 0.358974358974359 14.2 14 2 abnormal circulating hormone level 0.142379432046495 0.520667383442438 0.970629981439022 0.358974358974359 14.2 14 2 abnormal pancreatic islet morphology 0.0994396346870495 0.424281460178449 0.9693218547794 0.358490566037736 14.2 14 2 respiratory distress 0.00656754848883782 0.0791127209006493 0.969026959174052 0.358381502890173 14.2 14 2 abnormal femur morphology 0.0708650767891455 0.342732121070729 0.96856040791783 0.358208955223881 14.2 14 2 increased inflammatory response 0.0372842246927092 0.247780930160264 0.967710793524919 0.357894736842105 14.2 14 2 decreased exploration in new environment 0.0494601561816601 0.291200327815099 0.96567778765617 0.357142857142857 14.2 14 2 abnormal nervous system electrophysiology 0.0494601561816601 0.291200327815099 0.96567778765617 0.357142857142857 14.2 14 2 enhanced long term potentiation 0.0957769531961859 0.411832620700972 0.965677787656169 0.357142857142857 14.2 14 2 abnormal spleen germinal center morphology 0.201349290298854 0.605161793547883 0.965677787656169 0.357142857142857 14.2 14 2 increased bone resorption 0.201349290298854 0.605161793547883 0.965677787656169 0.357142857142857 14.2 14 2 abnormal renal tubule epithelium morphology 0.201349290298854 0.605161793547883 0.965677787656169 0.357142857142857 14.2 14 2 abnormal mitotic spindle morphology 0.201349290298854 0.605161793547883 0.965677787656169 0.357142857142857 14.2 14 2 absent atrioventricular cushions 0.319207896892571 0.675195275102271 0.965677787656169 0.357142857142857 14.2 14 2 irregularly shaped pupil 0.319207896892571 0.675195275102271 0.965677787656169 0.357142857142857 14.2 14 2 abnormal pinna reflex 0.319207896892571 0.675195275102271 0.965677787656169 0.357142857142857 14.2 14 2 abnormal spleen periarteriolar lymphoid sheath morphology 0.319207896892571 0.675195275102271 0.965677787656169 0.357142857142857 14.2 14 2 decreased coping response 0.319207896892571 0.675195275102271 0.965677787656169 0.357142857142857 14.2 14 2 intestinal obstruction 0.319207896892571 0.675195275102271 0.965677787656169 0.357142857142857 14.2 14 2 abnormal ventral body wall morphology 0.319207896892571 0.675195275102271 0.965677787656169 0.357142857142857 14.2 14 2 abnormal sagittal suture morphology 0.319207896892571 0.675195275102271 0.965677787656169 0.357142857142857 14.2 14 2 abnormal decidualization 0.319207896892571 0.675195275102271 0.965677787656169 0.357142857142857 14.2 14 2 decreased tongue size 0.319207896892571 0.675195275102271 0.965677787656169 0.357142857142857 14.2 14 2 increased lung compliance 0.319207896892571 0.675195275102271 0.965677787656169 0.357142857142857 14.2 14 2 decreased response to antigen 0.319207896892571 0.675195275102271 0.965677787656169 0.357142857142857 14.2 14 2 abnormal enzyme/coenzyme activity 0.0104487164906223 0.112515940564602 0.964447624869346 0.356687898089172 14.2 14 2 short limbs 0.0478062940689517 0.290948891067549 0.963457838719029 0.35632183908046 14.2 14 2 lethality at weaning, complete penetrance 0.131155099599439 0.49657277055343 0.961385886377698 0.355555555555556 14.2 14 2 abnormal cranial ganglia morphology 0.191995650938495 0.605161793547883 0.959447608380968 0.354838709677419 14.2 14 2 abnormal intestine physiology 0.191995650938495 0.605161793547883 0.959447608380968 0.354838709677419 14.2 14 2 abnormal intestinal epithelium morphology 0.12591297223685 0.478546246660299 0.957630472759035 0.354166666666667 14.2 14 2 oligodactyly 0.12591297223685 0.478546246660299 0.957630472759035 0.354166666666667 14.2 14 2 abnormal cardiovascular system morphology 0.12591297223685 0.478546246660299 0.957630472759035 0.354166666666667 14.2 14 2 abnormal hair shaft morphology 0.12591297223685 0.478546246660299 0.957630472759035 0.354166666666667 14.2 14 2 decreased monocyte cell number 0.0855763442664447 0.380559062389784 0.956763838847036 0.353846153846154 14.2 14 2 abnormal response/metabolism to endogenous compounds 0.0593445933294298 0.333625488080865 0.956256540947329 0.353658536585366 14.2 14 2 abnormal lung morphology 0.0285949826299506 0.212758949848027 0.954316872507274 0.352941176470588 14.2 14 2 abnormal retinal photoreceptor morphology 0.183221524170197 0.589222419357939 0.954316872507274 0.352941176470588 14.2 14 2 abnormal endoderm development 0.183221524170197 0.589222419357939 0.954316872507274 0.352941176470588 14.2 14 2 decreased regulatory T cell number 0.183221524170197 0.589222419357939 0.954316872507274 0.352941176470588 14.2 14 2 abnormal skin physiology 0.183221524170197 0.589222419357939 0.954316872507274 0.352941176470588 14.2 14 2 abnormal adipose tissue morphology 0.298828303474229 0.640254440044913 0.954316872507274 0.352941176470588 14.2 14 2 enlarged sebaceous gland 0.298828303474229 0.640254440044913 0.954316872507274 0.352941176470588 14.2 14 2 abnormal vagus nerve morphology 0.298828303474229 0.640254440044913 0.954316872507274 0.352941176470588 14.2 14 2 increased incidence of corneal inflammation 0.298828303474229 0.640254440044913 0.954316872507274 0.352941176470588 14.2 14 2 abnormal glutamate-mediated receptor currents 0.298828303474229 0.640254440044913 0.954316872507274 0.352941176470588 14.2 14 2 nephrocalcinosis 0.298828303474229 0.640254440044913 0.954316872507274 0.352941176470588 14.2 14 2 abnormal duodenum morphology 0.298828303474229 0.640254440044913 0.954316872507274 0.352941176470588 14.2 14 2 abnormal testis development 0.298828303474229 0.640254440044913 0.954316872507274 0.352941176470588 14.2 14 2 abnormal ectoplacental cone morphology 0.298828303474229 0.640254440044913 0.954316872507274 0.352941176470588 14.2 14 2 abnormal melanosome morphology 0.298828303474229 0.640254440044913 0.954316872507274 0.352941176470588 14.2 14 2 abnormal tarsal bone morphology 0.298828303474229 0.640254440044913 0.954316872507274 0.352941176470588 14.2 14 2 abnormal tendon morphology 0.298828303474229 0.640254440044913 0.954316872507274 0.352941176470588 14.2 14 2 increased hepatoma incidence 0.298828303474229 0.640254440044913 0.954316872507274 0.352941176470588 14.2 14 2 abnormal survival 0.298828303474229 0.640254440044913 0.954316872507274 0.352941176470588 14.2 14 2 short snout 0.0376141433457369 0.247780930160264 0.951371450061263 0.351851851851852 14.2 14 2 abnormal neuronal precursor proliferation 0.116119814367587 0.460315598787843 0.951371450061263 0.351851851851852 14.2 14 2 abnormal chromosome morphology 0.174975851949157 0.579638409541588 0.95001814785634 0.351351351351351 14.2 14 2 abnormal circulating amino acid level 0.111547876509804 0.448469571359015 0.948736072083254 0.350877192982456 14.2 14 2 increased macrophage cell number 0.111547876509804 0.448469571359015 0.948736072083254 0.350877192982456 14.2 14 2 abnormal cytokine secretion 0.0167762321083734 0.155422262084092 0.948120009698785 0.350649350649351 14.2 14 2 abnormal kidney development 0.107178544969815 0.443974405682621 0.946364231903046 0.35 14.2 14 2 abnormal pancreatic beta cell morphology 0.167213278607901 0.579638409541588 0.946364231903046 0.35 14.2 14 2 abnormal cell proliferation 0.280926861496713 0.638271278285046 0.946364231903046 0.35 14.2 14 2 abnormal circulating enzyme level 0.280926861496713 0.638271278285046 0.946364231903046 0.35 14.2 14 2 abnormal hearing physiology 0.280926861496713 0.638271278285046 0.946364231903046 0.35 14.2 14 2 abnormal hair texture 0.280926861496713 0.638271278285046 0.946364231903046 0.35 14.2 14 2 abnormal trachea morphology 0.280926861496713 0.638271278285046 0.946364231903046 0.35 14.2 14 2 abnormal Peyer's patch T cell area morphology 0.280926861496713 0.638271278285046 0.946364231903046 0.35 14.2 14 2 abnormal hyoid bone morphology 0.280926861496713 0.638271278285046 0.946364231903046 0.35 14.2 14 2 dilated vasculature 0.280926861496713 0.638271278285046 0.946364231903046 0.35 14.2 14 2 kidney atrophy 0.280926861496713 0.638271278285046 0.946364231903046 0.35 14.2 14 2 abnormal induced retinal neovascularization 0.280926861496713 0.638271278285046 0.946364231903046 0.35 14.2 14 2 enhanced behavioral response to xenobiotic 0.280926861496713 0.638271278285046 0.946364231903046 0.35 14.2 14 2 skin lesions 0.103001812999909 0.431075338652721 0.94421828126381 0.349206349206349 14.2 14 2 abnormal organ of Corti morphology 0.159893627836006 0.558617133766946 0.943220164687421 0.348837209302326 14.2 14 2 abnormal axon guidance 0.159893627836006 0.558617133766946 0.943220164687421 0.348837209302326 14.2 14 2 abnormal neuron differentiation 0.0416062066534154 0.267457512599384 0.941535842964765 0.348214285714286 14.2 14 2 conjunctivitis 0.264941899150589 0.634433926155609 0.940486193195574 0.347826086956522 14.2 14 2 pancreas inflammation 0.264941899150589 0.634433926155609 0.940486193195574 0.347826086956522 14.2 14 2 abnormal cochlear ganglion morphology 0.264941899150589 0.634433926155609 0.940486193195574 0.347826086956522 14.2 14 2 abnormal palatal shelf fusion at midline 0.264941899150589 0.634433926155609 0.940486193195574 0.347826086956522 14.2 14 2 eyelids open at birth 0.140255330935513 0.520667383442438 0.935964624959057 0.346153846153846 14.2 14 2 increased susceptibility to injury 0.140255330935513 0.520667383442438 0.935964624959057 0.346153846153846 14.2 14 2 abnormal leukocyte cell number 0.250497827602136 0.634433926155609 0.935964624959057 0.346153846153846 14.2 14 2 abnormal ureter morphology 0.250497827602136 0.634433926155609 0.935964624959057 0.346153846153846 14.2 14 2 abnormal Schwann cell morphology 0.250497827602136 0.634433926155609 0.935964624959057 0.346153846153846 14.2 14 2 pulmonary edema 0.250497827602136 0.634433926155609 0.935964624959057 0.346153846153846 14.2 14 2 abnormal dendritic cell physiology 0.0509947858306287 0.296484113343277 0.934992699076441 0.345794392523364 14.2 14 2 abnormal platelet physiology 0.134388230820186 0.50726968765586 0.934073787332877 0.345454545454545 14.2 14 2 increased neutrophil cell number 0.028272121580917 0.212758949848027 0.93237855359906 0.344827586206897 14.2 14 2 decreased bone strength 0.237328575318179 0.634433926155609 0.93237855359906 0.344827586206897 14.2 14 2 increased osteoclast cell number 0.123531944100531 0.478546246660299 0.930850064166931 0.344262295081967 14.2 14 2 decreased lymphocyte cell number 0.0396058179970245 0.2562274961446 0.929464870619063 0.34375 14.2 14 2 abnormal vertebral body morphology 0.225237242130035 0.634433926155609 0.929464870619063 0.34375 14.2 14 2 abnormal long term potentiation 0.225237242130035 0.634433926155609 0.929464870619063 0.34375 14.2 14 2 deafness 0.0648509268412656 0.3367822805716 0.928611367523912 0.343434343434343 14.2 14 2 postnatal lethality 0.0221702489461264 0.175912262371577 0.928446836806775 0.343373493975904 14.2 14 2 decreased compact bone thickness 0.113719186369042 0.451518716828397 0.928203724254587 0.343283582089552 14.2 14 2 thick epidermis 0.109162906636901 0.448469571359015 0.927050676149923 0.342857142857143 14.2 14 2 thick pulmonary interalveolar septum 0.214073054089614 0.627574502063293 0.927050676149923 0.342857142857143 14.2 14 2 abnormal artery morphology 0.214073054089614 0.627574502063293 0.927050676149923 0.342857142857143 14.2 14 2 decreased IgG level 0.0558539255984262 0.320355540619524 0.925658708167716 0.342342342342342 14.2 14 2 increased grooming behavior 0.203717349586639 0.605161793547883 0.925017670281173 0.342105263157895 14.2 14 2 abnormal retinal outer nuclear layer morphology 0.203717349586639 0.605161793547883 0.925017670281173 0.342105263157895 14.2 14 2 abnormal blood homeostasis 0.053823573624301 0.309921618959372 0.925017670281173 0.342105263157895 14.2 14 2 hunched posture 0.0967292919883837 0.415209859915625 0.924116971478562 0.341772151898734 14.2 14 2 liver fibrosis 0.194074619482545 0.605161793547883 0.923282177466387 0.341463414634146 14.2 14 2 increased tumor growth/size 0.194074619482545 0.605161793547883 0.923282177466387 0.341463414634146 14.2 14 2 palatal shelves fail to meet at midline 0.194074619482545 0.605161793547883 0.923282177466387 0.341463414634146 14.2 14 2 hyperglycemia 0.0859090955943673 0.380559062389784 0.921783342762707 0.340909090909091 14.2 14 2 small kidney 0.0859090955943673 0.380559062389784 0.921783342762707 0.340909090909091 14.2 14 2 osteoporosis 0.185066538584706 0.593238421043115 0.921783342762707 0.340909090909091 14.2 14 2 abnormal myelopoiesis 0.185066538584706 0.593238421043115 0.921783342762707 0.340909090909091 14.2 14 2 cochlear hair cell degeneration 0.185066538584706 0.593238421043115 0.921783342762707 0.340909090909091 14.2 14 2 enlarged kidney 0.161246260434722 0.561371690456782 0.918304915054169 0.339622641509434 14.2 14 2 increased body weight 0.0129621022594864 0.129490881005913 0.917393898273361 0.339285714285714 14.2 14 2 abnormal colon morphology 0.147576218541874 0.52655711864879 0.916575527266873 0.338983050847458 14.2 14 2 increased B cell proliferation 0.147576218541874 0.52655711864879 0.916575527266873 0.338983050847458 14.2 14 2 increased eosinophil cell number 0.14129693071008 0.520667383442438 0.915836353454561 0.338709677419355 14.2 14 2 decreased T cell proliferation 0.0405316423044868 0.261198083503655 0.913478988323404 0.337837837837838 14.2 14 2 weight loss 0.029335466678795 0.216167184779493 0.911599831547424 0.337142857142857 14.2 14 2 abnormal kidney morphology 0.029335466678795 0.216167184779493 0.911599831547424 0.337142857142857 14.2 14 2 abnormal trabecular bone morphology 0.0659234668790535 0.3367822805716 0.908873211911689 0.336134453781513 14.2 14 2 cleft palate 0.0567018064316793 0.322022245431056 0.908179415566718 0.33587786259542 14.2 14 2 decreased T cell number 0.0392491767698034 0.255136106189174 0.906897400581446 0.335403726708075 14.2 14 2 abnormal maxilla morphology 0.18380948346829 0.590350019531789 0.901299268479092 0.333333333333333 14.2 14 2 decreased platelet aggregation 0.18380948346829 0.590350019531789 0.901299268479092 0.333333333333333 14.2 14 2 head tossing 0.260537819684126 0.634433926155609 0.901299268479092 0.333333333333333 14.2 14 2 myeloid hyperplasia 0.260537819684126 0.634433926155609 0.901299268479092 0.333333333333333 14.2 14 2 wrinkled skin 0.29179239355914 0.638271278285046 0.901299268479092 0.333333333333333 14.2 14 2 increased metastatic potential 0.275416727295694 0.638271278285046 0.901299268479092 0.333333333333333 14.2 14 2 abnormal pain threshold 0.275416727295694 0.638271278285046 0.901299268479092 0.333333333333333 14.2 14 2 enhanced paired-pulse facilitation 0.275416727295694 0.638271278285046 0.901299268479092 0.333333333333333 14.2 14 2 abnormal optic cup morphology 0.275416727295694 0.638271278285046 0.901299268479092 0.333333333333333 14.2 14 2 abnormal fat pad morphology 0.275416727295694 0.638271278285046 0.901299268479092 0.333333333333333 14.2 14 2 small ears 0.330415502332549 0.696237663746053 0.901299268479092 0.333333333333333 14.2 14 2 abnormal scapula morphology 0.330415502332549 0.696237663746053 0.901299268479092 0.333333333333333 14.2 14 2 hypoalgesia 0.330415502332549 0.696237663746053 0.901299268479092 0.333333333333333 14.2 14 2 abnormal embryonic/fetal subventricular zone morphology 0.330415502332549 0.696237663746053 0.901299268479092 0.333333333333333 14.2 14 2 decreased cochlear outer hair cell number 0.330415502332549 0.696237663746053 0.901299268479092 0.333333333333333 14.2 14 2 increased acute inflammation 0.330415502332549 0.696237663746053 0.901299268479092 0.333333333333333 14.2 14 2 abnormal stapes morphology 0.330415502332549 0.696237663746053 0.901299268479092 0.333333333333333 14.2 14 2 abnormal tumor vascularization 0.330415502332549 0.696237663746053 0.901299268479092 0.333333333333333 14.2 14 2 increased bone ossification 0.330415502332549 0.696237663746053 0.901299268479092 0.333333333333333 14.2 14 2 decreased salivation 0.380943085381378 0.760922539578379 0.901299268479092 0.333333333333333 14.2 14 2 no suckling reflex 0.380943085381378 0.760922539578379 0.901299268479092 0.333333333333333 14.2 14 2 abnormal seizure response to electrical stimulation 0.380943085381378 0.760922539578379 0.901299268479092 0.333333333333333 14.2 14 2 abnormal apical ectodermal ridge morphology 0.380943085381378 0.760922539578379 0.901299268479092 0.333333333333333 14.2 14 2 increased airway responsiveness 0.380943085381378 0.760922539578379 0.901299268479092 0.333333333333333 14.2 14 2 joint inflammation 0.380943085381378 0.760922539578379 0.901299268479092 0.333333333333333 14.2 14 2 increased alcohol consumption 0.380943085381378 0.760922539578379 0.901299268479092 0.333333333333333 14.2 14 2 immune system phenotype 0.380943085381378 0.760922539578379 0.901299268479092 0.333333333333333 14.2 14 2 abnormal neurotransmitter secretion 0.380943085381378 0.760922539578379 0.901299268479092 0.333333333333333 14.2 14 2 abnormal energy homeostasis 0.380943085381378 0.760922539578379 0.901299268479092 0.333333333333333 14.2 14 2 abnormal dendritic cell morphology 0.380943085381378 0.760922539578379 0.901299268479092 0.333333333333333 14.2 14 2 liver vascular congestion 0.380943085381378 0.760922539578379 0.901299268479092 0.333333333333333 14.2 14 2 abnormal coronary vessel morphology 0.380943085381378 0.760922539578379 0.901299268479092 0.333333333333333 14.2 14 2 herniated liver 0.380943085381378 0.760922539578379 0.901299268479092 0.333333333333333 14.2 14 2 spleen hypoplasia 0.0897358470572923 0.389323542877966 0.901299268479092 0.333333333333333 14.2 14 2 increased susceptibility to pharmacologically induced seizures 0.101100082127403 0.430627490225882 0.901299268479092 0.333333333333333 14.2 14 2 abnormal urine homeostasis 0.101100082127403 0.430627490225882 0.901299268479092 0.333333333333333 14.2 14 2 increased urine protein level 0.129315434145861 0.48998041498527 0.901299268479092 0.333333333333333 14.2 14 2 abnormal heart ventricle morphology 0.129315434145861 0.48998041498527 0.901299268479092 0.333333333333333 14.2 14 2 hyperkeratosis 0.146973944177768 0.52655711864879 0.901299268479092 0.333333333333333 14.2 14 2 abnormal osteoclast morphology 0.201985290811392 0.605161793547883 0.901299268479092 0.333333333333333 14.2 14 2 irregular heartbeat 0.212022258077341 0.622307217660631 0.901299268479092 0.333333333333333 14.2 14 2 albuminuria 0.212022258077341 0.622307217660631 0.901299268479092 0.333333333333333 14.2 14 2 decreased osteoclast cell number 0.212022258077341 0.622307217660631 0.901299268479092 0.333333333333333 14.2 14 2 cardiomyopathy 0.212022258077341 0.622307217660631 0.901299268479092 0.333333333333333 14.2 14 2 abnormal systemic arterial blood pressure 0.246921101347228 0.634433926155609 0.901299268479092 0.333333333333333 14.2 14 2 abnormal iris morphology 0.234386308356711 0.634433926155609 0.901299268479092 0.333333333333333 14.2 14 2 impaired wound healing 0.246921101347228 0.634433926155609 0.901299268479092 0.333333333333333 14.2 14 2 acanthosis 0.234386308356711 0.634433926155609 0.901299268479092 0.333333333333333 14.2 14 2 increased vascular permeability 0.234386308356711 0.634433926155609 0.901299268479092 0.333333333333333 14.2 14 2 abnormal leukocyte adhesion 0.234386308356711 0.634433926155609 0.901299268479092 0.333333333333333 14.2 14 2 abnormal response to injury 0.234386308356711 0.634433926155609 0.901299268479092 0.333333333333333 14.2 14 2 abnormal malleus morphology 0.30997937714474 0.661298199526192 0.901299268479092 0.333333333333333 14.2 14 2 increased stereotypic behavior 0.30997937714474 0.661298199526192 0.901299268479092 0.333333333333333 14.2 14 2 abnormal startle reflex 0.30997937714474 0.661298199526192 0.901299268479092 0.333333333333333 14.2 14 2 blindness 0.30997937714474 0.661298199526192 0.901299268479092 0.333333333333333 14.2 14 2 increased circulating total protein level 0.30997937714474 0.661298199526192 0.901299268479092 0.333333333333333 14.2 14 2 abnormal stomach glandular epithelium morphology 0.353739601292244 0.735110491407232 0.901299268479092 0.333333333333333 14.2 14 2 absent spleen 0.353739601292244 0.735110491407232 0.901299268479092 0.333333333333333 14.2 14 2 thick dermal layer 0.353739601292244 0.735110491407232 0.901299268479092 0.333333333333333 14.2 14 2 abnormal iron level 0.353739601292244 0.735110491407232 0.901299268479092 0.333333333333333 14.2 14 2 abnormal thymus cortex morphology 0.353739601292244 0.735110491407232 0.901299268479092 0.333333333333333 14.2 14 2 abnormal renal glomerulus morphology 0.0964746797889675 0.414474552633949 0.893030467850843 0.330275229357798 14.2 14 2 decreased IgM level 0.113235999626499 0.449959343563766 0.892007523443225 0.329896907216495 14.2 14 2 increased thermal nociceptive threshold 0.122883009766265 0.478546246660299 0.891394880913387 0.32967032967033 14.2 14 2 abnormal tooth morphology 0.180927175035915 0.584488763508882 0.887216467409106 0.328125 14.2 14 2 increased circulating calcium level 0.207852255026826 0.612960858777986 0.884912009052199 0.327272727272727 14.2 14 2 abnormal intestinal mucosa morphology 0.253155890173536 0.634433926155609 0.880338820374927 0.325581395348837 14.2 14 2 abnormal social investigation 0.162376734464729 0.564912065707712 0.878766786767114 0.325 14.2 14 2 head bobbing 0.266728878235768 0.634433926155609 0.878766786767114 0.325 14.2 14 2 increased susceptibility to weight loss 0.266728878235768 0.634433926155609 0.878766786767114 0.325 14.2 14 2 increased white adipose tissue amount 0.281454821058301 0.638271278285046 0.876939828790468 0.324324324324324 14.2 14 2 abnormal breathing pattern 0.281454821058301 0.638271278285046 0.876939828790468 0.324324324324324 14.2 14 2 impaired synaptic plasticity 0.297515178408179 0.640254440044913 0.874790466465001 0.323529411764706 14.2 14 2 decreased osteoblast cell number 0.297515178408179 0.640254440044913 0.874790466465001 0.323529411764706 14.2 14 2 absent mature ovarian follicles 0.31514104937055 0.670871510748176 0.872225098528153 0.32258064516129 14.2 14 2 abnormal nose morphology 0.31514104937055 0.670871510748176 0.872225098528153 0.32258064516129 14.2 14 2 abnormal retinal photoreceptor layer morphology 0.31514104937055 0.670871510748176 0.872225098528153 0.32258064516129 14.2 14 2 pale kidney 0.31514104937055 0.670871510748176 0.872225098528153 0.32258064516129 14.2 14 2 preaxial polydactyly 0.31514104937055 0.670871510748176 0.872225098528153 0.32258064516129 14.2 14 2 reddish skin 0.334633863524539 0.703933814390944 0.869110008890553 0.321428571428571 14.2 14 2 abnormal respiration 0.334633863524539 0.703933814390944 0.869110008890553 0.321428571428571 14.2 14 2 enhanced coordination 0.334633863524539 0.703933814390944 0.869110008890553 0.321428571428571 14.2 14 2 abnormal limb morphology 0.197041767405399 0.605161793547883 0.865247297739928 0.32 14.2 14 2 mandible hypoplasia 0.356398223282261 0.7378614901495 0.865247297739928 0.32 14.2 14 2 abnormal keratinocyte physiology 0.356398223282261 0.7378614901495 0.865247297739928 0.32 14.2 14 2 impaired conditioned place preference behavior 0.356398223282261 0.7378614901495 0.865247297739928 0.32 14.2 14 2 increased susceptibility to bacterial infection induced morbidity/mortality 0.206022593954918 0.607925507073378 0.863745132292463 0.319444444444444 14.2 14 2 abnormal innervation 0.270572949578677 0.634433926155609 0.862946108118279 0.319148936170213 14.2 14 2 abnormal coat appearance 0.215533463799317 0.631123591760802 0.862112343762609 0.318840579710145 14.2 14 2 abnormal photoreceptor outer segment morphology 0.28493092091499 0.638271278285046 0.86033111991186 0.318181818181818 14.2 14 2 decreased macrophage cell number 0.28493092091499 0.638271278285046 0.86033111991186 0.318181818181818 14.2 14 2 abnormal long bone epiphysis morphology 0.380996592178843 0.760922539578379 0.86033111991186 0.318181818181818 14.2 14 2 abnormal retinal outer plexiform layer morphology 0.380996592178843 0.760922539578379 0.86033111991186 0.318181818181818 14.2 14 2 decreased circulating estradiol level 0.380996592178843 0.760922539578379 0.86033111991186 0.318181818181818 14.2 14 2 abnormal occipital bone morphology 0.380996592178843 0.760922539578379 0.86033111991186 0.318181818181818 14.2 14 2 decreased susceptibility to viral infection induced morbidity/mortality 0.380996592178843 0.760922539578379 0.86033111991186 0.318181818181818 14.2 14 2 failure of palatal shelf elevation 0.380996592178843 0.760922539578379 0.86033111991186 0.318181818181818 14.2 14 2 abnormal cerebral cortex pyramidal cell morphology 0.380996592178843 0.760922539578379 0.86033111991186 0.318181818181818 14.2 14 2 pulmonary vascular congestion 0.380996592178843 0.760922539578379 0.86033111991186 0.318181818181818 14.2 14 2 impaired humoral immune response 0.380996592178843 0.760922539578379 0.86033111991186 0.318181818181818 14.2 14 2 scaly skin 0.300461212656907 0.643199024512957 0.857333450504502 0.317073170731707 14.2 14 2 arrested B cell differentiation 0.300461212656907 0.643199024512957 0.857333450504502 0.317073170731707 14.2 14 2 abnormal eye physiology 0.24773709400025 0.634433926155609 0.856234305055137 0.316666666666667 14.2 14 2 abnormal response to infection 0.208572955210206 0.614721831854725 0.85566386248015 0.316455696202532 14.2 14 2 abnormal compact bone morphology 0.317333654045223 0.67467304652777 0.853862464874929 0.315789473684211 14.2 14 2 impaired branching involved in ureteric bud morphogenesis 0.317333654045223 0.67467304652777 0.853862464874929 0.315789473684211 14.2 14 2 irregular coat pigmentation 0.409245884246492 0.790149189641632 0.853862464874929 0.315789473684211 14.2 14 2 abnormal long term depression 0.409245884246492 0.790149189641632 0.853862464874929 0.315789473684211 14.2 14 2 osteoarthritis 0.409245884246492 0.790149189641632 0.853862464874929 0.315789473684211 14.2 14 2 decreased circulating magnesium level 0.409245884246492 0.790149189641632 0.853862464874929 0.315789473684211 14.2 14 2 shortened RR interval 0.409245884246492 0.790149189641632 0.853862464874929 0.315789473684211 14.2 14 2 abnormal small intestine morphology 0.272885032876258 0.634987389410377 0.85122708689692 0.314814814814815 14.2 14 2 abnormal action potential 0.23847590985118 0.634433926155609 0.849796453137429 0.314285714285714 14.2 14 2 cataract 0.160648652032284 0.560861083410957 0.849157988484433 0.31404958677686 14.2 14 2 abnormal cued conditioning behavior 0.286800865415686 0.638271278285046 0.84828166445091 0.313725490196078 14.2 14 2 abnormal kidney physiology 0.301749158109261 0.645678306061751 0.844968064199148 0.3125 14.2 14 2 abnormal heart atrium morphology 0.356006416298057 0.7378614901495 0.844968064199148 0.3125 14.2 14 2 abnormal depression-related behavior 0.356006416298057 0.7378614901495 0.844968064199148 0.3125 14.2 14 2 decreased susceptibility to parasitic infection 0.356006416298057 0.7378614901495 0.844968064199148 0.3125 14.2 14 2 abnormal auditory brainstem response waveform shape 0.356006416298057 0.7378614901495 0.844968064199148 0.3125 14.2 14 2 vasculature congestion 0.442401209573685 0.803529878747147 0.844968064199148 0.3125 14.2 14 2 decreased cochlear coiling 0.442401209573685 0.803529878747147 0.844968064199148 0.3125 14.2 14 2 decreased aggression towards mice 0.442401209573685 0.803529878747147 0.844968064199148 0.3125 14.2 14 2 bowed tibia 0.442401209573685 0.803529878747147 0.844968064199148 0.3125 14.2 14 2 abnormal wound healing 0.442401209573685 0.803529878747147 0.844968064199148 0.3125 14.2 14 2 increased circulating estradiol level 0.442401209573685 0.803529878747147 0.844968064199148 0.3125 14.2 14 2 decreased circulating triiodothyronine level 0.442401209573685 0.803529878747147 0.844968064199148 0.3125 14.2 14 2 impaired somite development 0.442401209573685 0.803529878747147 0.844968064199148 0.3125 14.2 14 2 embryonic lethality between somite formation and embryo turning, incomplete penetrance 0.442401209573685 0.803529878747147 0.844968064199148 0.3125 14.2 14 2 decreased midbrain size 0.442401209573685 0.803529878747147 0.844968064199148 0.3125 14.2 14 2 decreased fibroblast apoptosis 0.442401209573685 0.803529878747147 0.844968064199148 0.3125 14.2 14 2 abnormal maternal nurturing 0.274147109017298 0.637625931445094 0.842197677103413 0.311475409836066 14.2 14 2 abnormal spinal nerve morphology 0.378421243217402 0.760922539578379 0.839140698239154 0.310344827586207 14.2 14 2 aphagia 0.378421243217402 0.760922539578379 0.839140698239154 0.310344827586207 14.2 14 2 absent long term depression 0.378421243217402 0.760922539578379 0.839140698239154 0.310344827586207 14.2 14 2 enlarged epididymis 0.378421243217402 0.760922539578379 0.839140698239154 0.310344827586207 14.2 14 2 abnormal skeletal muscle fiber morphology 0.262405069480509 0.634433926155609 0.837827489008733 0.309859154929577 14.2 14 2 decreased inflammatory response 0.240798275757174 0.634433926155609 0.836920749302014 0.30952380952381 14.2 14 2 abnormal cartilage morphology 0.335278700238009 0.704992195132754 0.836920749302014 0.30952380952381 14.2 14 2 abnormal T-helper 2 physiology 0.301978644019425 0.645891553738883 0.835750230771521 0.309090909090909 14.2 14 2 decreased susceptibility to injury 0.274662871705972 0.638271278285046 0.835027263443864 0.308823529411765 14.2 14 2 cleft secondary palate 0.231348690249171 0.634433926155609 0.83418123784767 0.308510638297872 14.2 14 2 decreased B-1 B cell number 0.354199141017894 0.735451054492498 0.831968555519161 0.307692307692308 14.2 14 2 decreased trabecular bone volume 0.354199141017894 0.735451054492498 0.831968555519161 0.307692307692308 14.2 14 2 abnormal kidney cortex morphology 0.403465065806762 0.790149189641632 0.831968555519161 0.307692307692308 14.2 14 2 abnormal ocular fundus morphology 0.403465065806762 0.790149189641632 0.831968555519161 0.307692307692308 14.2 14 2 abnormal eye electrophysiology 0.21419527728713 0.627574502063293 0.82681172562958 0.305785123966942 14.2 14 2 abnormal inflammatory response 0.287213358711769 0.638271278285046 0.826190996105834 0.305555555555556 14.2 14 2 syndactyly 0.316224581581052 0.672890202466096 0.824917974540185 0.305084745762712 14.2 14 2 abnormal immune system morphology 0.351661701113383 0.732321876533729 0.822925419046127 0.304347826086957 14.2 14 2 abnormal lymphocyte physiology 0.351661701113383 0.732321876533729 0.822925419046127 0.304347826086957 14.2 14 2 bidirectional circling 0.431770520378703 0.803529878747147 0.822925419046127 0.304347826086957 14.2 14 2 decreased epididymis weight 0.431770520378703 0.803529878747147 0.822925419046127 0.304347826086957 14.2 14 2 dilated heart 0.431770520378703 0.803529878747147 0.822925419046127 0.304347826086957 14.2 14 2 increased susceptibility to fungal infection 0.431770520378703 0.803529878747147 0.822925419046127 0.304347826086957 14.2 14 2 abnormal seminal vesicle morphology 0.331933329720622 0.699139845622395 0.820826119507744 0.303571428571429 14.2 14 2 abnormal epidermis stratum basale morphology 0.397514501782375 0.790149189641632 0.819362971344629 0.303030303030303 14.2 14 2 absent vibrissae 0.397514501782375 0.790149189641632 0.819362971344629 0.303030303030303 14.2 14 2 diarrhea 0.397514501782375 0.790149189641632 0.819362971344629 0.303030303030303 14.2 14 2 abnormal male reproductive system morphology 0.370865251265947 0.750969917438016 0.817457476062432 0.302325581395349 14.2 14 2 decreased oxygen consumption 0.370865251265947 0.750969917438016 0.817457476062432 0.302325581395349 14.2 14 2 abnormal digestive system physiology 0.366725290202217 0.750969917438016 0.811169341631182 0.3 14.2 14 2 abnormal pericardium morphology 0.464239751139255 0.803529878747147 0.811169341631182 0.3 14.2 14 2 gastrointestinal hemorrhage 0.422566035755277 0.803529878747147 0.811169341631182 0.3 14.2 14 2 delayed eyelid opening 0.422566035755277 0.803529878747147 0.811169341631182 0.3 14.2 14 2 salivary gland inflammation 0.422566035755277 0.803529878747147 0.811169341631182 0.3 14.2 14 2 spleen atrophy 0.464239751139255 0.803529878747147 0.811169341631182 0.3 14.2 14 2 abnormal thymocyte activation 0.464239751139255 0.803529878747147 0.811169341631182 0.3 14.2 14 2 abnormal optic stalk morphology 0.464239751139255 0.803529878747147 0.811169341631182 0.3 14.2 14 2 abnormal neuron proliferation 0.464239751139255 0.803529878747147 0.811169341631182 0.3 14.2 14 2 nuclear cataracts 0.464239751139255 0.803529878747147 0.811169341631182 0.3 14.2 14 2 increased sensitivity to induced morbidity/mortality 0.209698984116365 0.617674627577808 0.808230322277446 0.298913043478261 14.2 14 2 abnormal immune system physiology 0.26703692110865 0.634433926155609 0.806808216138542 0.298387096774194 14.2 14 2 decreased susceptibility to induced arthritis 0.362549940743031 0.750285339100074 0.806425661270766 0.298245614035088 14.2 14 2 increased systemic arterial blood pressure 0.386062989643258 0.770731690800645 0.805416367577061 0.297872340425532 14.2 14 2 abnormal T cell differentiation 0.303827775914523 0.649567333551677 0.803137962011072 0.297029702970297 14.2 14 2 abnormal cochlea morphology 0.380661540523536 0.760922539578379 0.801154905314748 0.296296296296296 14.2 14 2 abnormal brain commissure morphology 0.450485138332076 0.803529878747147 0.801154905314748 0.296296296296296 14.2 14 2 abnormal single cell response 0.450485138332076 0.803529878747147 0.801154905314748 0.296296296296296 14.2 14 2 abnormal inhibitory postsynaptic currents 0.370496637972892 0.750969917438016 0.795264060422728 0.294117647058824 14.2 14 2 abnormal vision 0.439180886521623 0.803529878747147 0.795264060422728 0.294117647058824 14.2 14 2 abnormal bone remodeling 0.439180886521623 0.803529878747147 0.795264060422728 0.294117647058824 14.2 14 2 hydroureter 0.502223253781791 0.851541147973769 0.795264060422728 0.294117647058824 14.2 14 2 abnormal urinary bladder morphology 0.502223253781791 0.851541147973769 0.795264060422728 0.294117647058824 14.2 14 2 increased trabecular bone mass 0.502223253781791 0.851541147973769 0.795264060422728 0.294117647058824 14.2 14 2 cochlear inner hair cell degeneration 0.400027133863272 0.790149189641632 0.795264060422728 0.294117647058824 14.2 14 2 abnormal CNS synaptic transmission 0.338764074260836 0.71201997019335 0.792050872299808 0.292929292929293 14.2 14 2 curly vibrissae 0.481919814651511 0.824679292449142 0.788636859919205 0.291666666666667 14.2 14 2 abnormal sensory capabilities/reflexes/nociception 0.481919814651511 0.824679292449142 0.788636859919205 0.291666666666667 14.2 14 2 abnormal retinal ganglion layer morphology 0.481919814651511 0.824679292449142 0.788636859919205 0.291666666666667 14.2 14 2 decreased fatty acid level 0.481919814651511 0.824679292449142 0.788636859919205 0.291666666666667 14.2 14 2 abnormal eyelid morphology 0.466512621094483 0.803529878747147 0.785002588675338 0.290322580645161 14.2 14 2 abnormal object recognition memory 0.466512621094483 0.803529878747147 0.785002588675338 0.290322580645161 14.2 14 2 abnormal CD8-positive, alpha beta T cell morphology 0.466512621094483 0.803529878747147 0.785002588675338 0.290322580645161 14.2 14 2 increased bone marrow cell number 0.453890703843644 0.803529878747147 0.782707259468685 0.289473684210526 14.2 14 2 abnormal autopod morphology 0.44307668448197 0.803529878747147 0.781126032681879 0.288888888888889 14.2 14 2 abnormal optic nerve morphology 0.467097167705879 0.803529878747147 0.772542230124936 0.285714285714286 14.2 14 2 abnormal salivary gland morphology 0.517769450661937 0.858634339014379 0.772542230124936 0.285714285714286 14.2 14 2 dry skin 0.517769450661937 0.858634339014379 0.772542230124936 0.285714285714286 14.2 14 2 vascular ring 0.517769450661937 0.858634339014379 0.772542230124936 0.285714285714286 14.2 14 2 short mandible 0.445345052580397 0.803529878747147 0.772542230124936 0.285714285714286 14.2 14 2 impaired adaptive thermogenesis 0.480549446975264 0.824679292449142 0.772542230124936 0.285714285714286 14.2 14 2 abnormal stria vascularis morphology 0.49682564825509 0.847055380421204 0.772542230124936 0.285714285714286 14.2 14 2 shortened head 0.49682564825509 0.847055380421204 0.772542230124936 0.285714285714286 14.2 14 2 absent corpus callosum 0.49682564825509 0.847055380421204 0.772542230124936 0.285714285714286 14.2 14 2 decreased circulating progesterone level 0.49682564825509 0.847055380421204 0.772542230124936 0.285714285714286 14.2 14 2 corneal vascularization 0.49682564825509 0.847055380421204 0.772542230124936 0.285714285714286 14.2 14 2 abnormal T cell activation 0.437950494132253 0.803529878747147 0.767322350191659 0.283783783783784 14.2 14 2 increased autoantibody level 0.49305524638233 0.842069979660863 0.762637842559231 0.282051282051282 14.2 14 2 abnormal crypts of Lieberkuhn morphology 0.509754179493084 0.851541147973769 0.760471257779234 0.28125 14.2 14 2 increased dopamine level 0.509754179493084 0.851541147973769 0.760471257779234 0.28125 14.2 14 2 abnormal excitatory postsynaptic potential 0.456679705744827 0.803529878747147 0.758410360061675 0.280487804878049 14.2 14 2 abnormal hindlimb morphology 0.490078669335576 0.837273825530389 0.757091385522437 0.28 14.2 14 2 abnormal feces composition 0.530733766850664 0.874499392258082 0.757091385522437 0.28 14.2 14 2 decreased acute inflammation 0.530733766850664 0.874499392258082 0.757091385522437 0.28 14.2 14 2 increased liver glycogen level 0.530733766850664 0.874499392258082 0.757091385522437 0.28 14.2 14 2 abnormal stomach mucosa morphology 0.530733766850664 0.874499392258082 0.757091385522437 0.28 14.2 14 2 heart right ventricle hypertrophy 0.521203705671423 0.863466012559218 0.751082723732576 0.277777777777778 14.2 14 2 abnormal epidermis stratum granulosum morphology 0.521203705671423 0.863466012559218 0.751082723732576 0.277777777777778 14.2 14 2 abnormal limb bone morphology 0.521203705671423 0.863466012559218 0.751082723732576 0.277777777777778 14.2 14 2 abnormal mammary gland morphology 0.559332350893156 0.907888563032121 0.751082723732576 0.277777777777778 14.2 14 2 abnormal thymus medulla morphology 0.559332350893156 0.907888563032121 0.751082723732576 0.277777777777778 14.2 14 2 decreased heart rate variability 0.559332350893156 0.907888563032121 0.751082723732576 0.277777777777778 14.2 14 2 abnormal neutrophil morphology 0.559332350893156 0.907888563032121 0.751082723732576 0.277777777777778 14.2 14 2 small thoracic cage 0.559332350893156 0.907888563032121 0.751082723732576 0.277777777777778 14.2 14 2 abnormal aerobic respiration 0.559332350893156 0.907888563032121 0.751082723732576 0.277777777777778 14.2 14 2 increased adipocyte glucose uptake 0.559332350893156 0.907888563032121 0.751082723732576 0.277777777777778 14.2 14 2 abnormal T-helper 1 physiology 0.514657281562197 0.85432765291022 0.747886627035842 0.276595744680851 14.2 14 2 glomerulosclerosis 0.509667014863987 0.851541147973769 0.745902842879248 0.275862068965517 14.2 14 2 focal hair loss 0.541932088269447 0.887462850276662 0.745902842879248 0.275862068965517 14.2 14 2 abnormal outer ear morphology 0.541932088269447 0.887462850276662 0.745902842879248 0.275862068965517 14.2 14 2 short sternum 0.541932088269447 0.887462850276662 0.745902842879248 0.275862068965517 14.2 14 2 abnormal female reproductive system morphology 0.531505499787511 0.874499392258082 0.743571896495251 0.275 14.2 14 2 perinatal lethality 0.531505499787511 0.874499392258082 0.743571896495251 0.275 14.2 14 2 abnormal skin pigmentation 0.531505499787511 0.874499392258082 0.743571896495251 0.275 14.2 14 2 belly spot 0.5518440586346 0.898371790480084 0.737426674210166 0.272727272727273 14.2 14 2 increased cardiomyocyte apoptosis 0.5518440586346 0.898371790480084 0.737426674210166 0.272727272727273 14.2 14 2 abnormal T cell subpopulation ratio 0.5518440586346 0.898371790480084 0.737426674210166 0.272727272727273 14.2 14 2 obese 0.521724692248857 0.864041392788969 0.737426674210166 0.272727272727273 14.2 14 2 abnormal basisphenoid bone morphology 0.569059272593097 0.917473948020335 0.737426674210166 0.272727272727273 14.2 14 2 increased myocardial infarction size 0.569059272593097 0.917473948020335 0.737426674210166 0.272727272727273 14.2 14 2 abnormal tracheal cartilage morphology 0.569059272593097 0.917473948020335 0.737426674210166 0.272727272727273 14.2 14 2 abnormal retinal layer morphology 0.569059272593097 0.917473948020335 0.737426674210166 0.272727272727273 14.2 14 2 abnormal circulating lipid level 0.569059272593097 0.917473948020335 0.737426674210166 0.272727272727273 14.2 14 2 abnormal lymph node morphology 0.549525819115964 0.895476891615435 0.732305655639262 0.270833333333333 14.2 14 2 increased trabecular bone volume 0.560775066463219 0.909933449332849 0.730783190658723 0.27027027027027 14.2 14 2 decreased IgA level 0.557536297993186 0.9070448275069 0.727972486079266 0.269230769230769 14.2 14 2 abnormal stomach morphology 0.577622235656313 0.917473948020335 0.727972486079266 0.269230769230769 14.2 14 2 abnormal tectorial membrane morphology 0.577622235656313 0.917473948020335 0.727972486079266 0.269230769230769 14.2 14 2 decreased bone resorption 0.577622235656313 0.917473948020335 0.727972486079266 0.269230769230769 14.2 14 2 reduced long term potentiation 0.556202715175297 0.905171248935918 0.724258340742127 0.267857142857143 14.2 14 2 abnormal cartilage development 0.576459137679331 0.917473948020335 0.721039414783273 0.266666666666667 14.2 14 2 decreased food intake 0.575879555344568 0.917473948020335 0.718757644483326 0.265822784810127 14.2 14 2 abnormal epidermis stratum corneum morphology 0.583465242649033 0.917473948020335 0.717360642258869 0.26530612244898 14.2 14 2 short maxilla 0.592402800595272 0.917473948020335 0.715737654380455 0.264705882352941 14.2 14 2 decreased cytotoxic T cell cytolysis 0.592402800595272 0.917473948020335 0.715737654380455 0.264705882352941 14.2 14 2 abnormal frontal bone morphology 0.598948053113067 0.917473948020335 0.711552054062441 0.263157894736842 14.2 14 2 abnormal nail morphology 0.612934660409821 0.918202329279994 0.711552054062441 0.263157894736842 14.2 14 2 shiny skin 0.612934660409821 0.918202329279994 0.711552054062441 0.263157894736842 14.2 14 2 unresponsive to tactile stimuli 0.612934660409821 0.918202329279994 0.711552054062441 0.263157894736842 14.2 14 2 altered susceptibility to infection 0.612934660409821 0.918202329279994 0.711552054062441 0.263157894736842 14.2 14 2 decreased germ cell number 0.612934660409821 0.918202329279994 0.711552054062441 0.263157894736842 14.2 14 2 abnormal nasal septum morphology 0.612934660409821 0.918202329279994 0.711552054062441 0.263157894736842 14.2 14 2 decreased eye pigmentation 0.612934660409821 0.918202329279994 0.711552054062441 0.263157894736842 14.2 14 2 decreased liver glycogen level 0.612934660409821 0.918202329279994 0.711552054062441 0.263157894736842 14.2 14 2 abnormal NK cell physiology 0.602077546248436 0.917473948020335 0.709219096508138 0.262295081967213 14.2 14 2 blistering 0.617514126315825 0.923949707795858 0.70536464489668 0.260869565217391 14.2 14 2 abnormal regulatory T cell physiology 0.617514126315825 0.923949707795858 0.70536464489668 0.260869565217391 14.2 14 2 abnormal corneal stroma morphology 0.617514126315825 0.923949707795858 0.70536464489668 0.260869565217391 14.2 14 2 abnormal lens development 0.617514126315825 0.923949707795858 0.70536464489668 0.260869565217391 14.2 14 2 decreased susceptibility to pharmacologically induced seizures 0.622120219719796 0.930281963662754 0.701010542150405 0.259259259259259 14.2 14 2 abnormal palate morphology 0.622120219719796 0.930281963662754 0.701010542150405 0.259259259259259 14.2 14 2 abnormal T cell proliferation 0.626668466226578 0.936520162053837 0.697780078822522 0.258064516129032 14.2 14 2 abnormal podocyte morphology 0.626668466226578 0.936520162053837 0.697780078822522 0.258064516129032 14.2 14 2 abnormal humoral immune response 0.652666925750117 0.974495184755951 0.695288007112442 0.257142857142857 14.2 14 2 small lens 0.635462814054701 0.949377627604245 0.693307129599301 0.256410256410256 14.2 14 2 abnormal response to novel object 0.64779302388277 0.967508343985825 0.689228852366364 0.254901960784314 14.2 14 2 prolonged QT interval 0.662712230203929 0.986926153928741 0.675974451359319 0.25 14.2 14 2 increased urine glucose level 0.662499630166677 0.986926153928741 0.675974451359319 0.25 14.2 14 2 decreased paired-pulse facilitation 0.662499630166677 0.986926153928741 0.675974451359319 0.25 14.2 14 2 decreased skin tensile strength 0.662499630166677 0.986926153928741 0.675974451359319 0.25 14.2 14 2 abnormal lens epithelium morphology 0.662499630166677 0.986926153928741 0.675974451359319 0.25 14.2 14 2 abnormal heart right ventricle morphology 0.662499630166677 0.986926153928741 0.675974451359319 0.25 14.2 14 2 increased urine calcium level 0.662499630166677 0.986926153928741 0.675974451359319 0.25 14.2 14 2 impaired ovarian folliculogenesis 0.670115252143764 0.991324228193645 0.675974451359319 0.25 14.2 14 2 altered response to myocardial infarction 0.703731501904639 1 0.660952796884667 0.244444444444444 14.2 14 2 short humerus 0.702755190915245 1 0.659487269618848 0.24390243902439 14.2 14 2 abnormal pancreatic beta cell physiology 0.702148618223155 1 0.657704871592851 0.243243243243243 14.2 14 2 abnormal middle ear ossicle morphology 0.702054562818747 1 0.655490377075703 0.242424242424242 14.2 14 2 decreased sensitivity to xenobiotic induced morbidity/mortality 0.702054562818747 1 0.655490377075703 0.242424242424242 14.2 14 2 decreased granulocyte number 0.702688300521823 1 0.652664987519342 0.241379310344828 14.2 14 2 increased susceptibility to induced arthritis 0.702688300521823 1 0.652664987519342 0.241379310344828 14.2 14 2 polyphagia 0.733370242884727 1 0.650938360568233 0.240740740740741 14.2 14 2 increased incidence of induced tumors 0.707727811261908 1 0.64378519177078 0.238095238095238 14.2 14 2 abnormal associative learning 0.707727811261908 1 0.64378519177078 0.238095238095238 14.2 14 2 abnormal estrous cycle 0.7384036320358 1 0.630909487935364 0.233333333333333 14.2 14 2 increased susceptibility to parasitic infection 0.815901482073628 1 0.630909487935364 0.233333333333333 14.2 14 2 abnormal leukocyte migration 0.783603395857613 1 0.623976416639371 0.230769230769231 14.2 14 2 abnormal phalanx morphology 0.785419835479833 1 0.619643247079375 0.229166666666667 14.2 14 2 decreased cardiac output 0.748512675576264 1 0.614522228508472 0.227272727272727 14.2 14 2 cleft upper lip 0.748512675576264 1 0.614522228508472 0.227272727272727 14.2 14 2 diluted coat color 0.826996899818097 1 0.600866178986061 0.222222222222222 14.2 14 2 cryptorchism 0.776791186941441 1 0.600866178986061 0.222222222222222 14.2 14 2 short radius 0.795106758816177 1 0.600866178986061 0.222222222222222 14.2 14 2 short ulna 0.815801523116497 1 0.593538542656963 0.219512195121951 14.2 14 2 abnormal carpal bone morphology 0.784901161481941 1 0.587803870747234 0.217391304347826 14.2 14 2 abnormal retinal cone cell morphology 0.784901161481941 1 0.587803870747234 0.217391304347826 14.2 14 2 increased susceptibility to age related obesity 0.784901161481941 1 0.587803870747234 0.217391304347826 14.2 14 2 abnormal crista ampullaris morphology 0.784901161481941 1 0.587803870747234 0.217391304347826 14.2 14 2 abnormal B cell morphology 0.784901161481941 1 0.587803870747234 0.217391304347826 14.2 14 2 abnormal hair follicle development 0.820750383807356 1 0.584626552526978 0.216216216216216 14.2 14 2 abnormal vibrissa morphology 0.838306573391108 1 0.579406672593702 0.214285714285714 14.2 14 2 abnormal cytotoxic T cell physiology 0.838306573391108 1 0.579406672593702 0.214285714285714 14.2 14 2 abnormal jaw morphology 0.807583762414189 1 0.579406672593702 0.214285714285714 14.2 14 2 increased circulating luteinizing hormone level 0.807583762414189 1 0.579406672593702 0.214285714285714 14.2 14 2 abnormal osteoblast morphology 0.817056143397208 1 0.563312042799432 0.208333333333333 14.2 14 2 abnormal cellular extravasation 0.817056143397208 1 0.563312042799432 0.208333333333333 14.2 14 2 abnormal coat/ hair morphology 0.883226114202873 1 0.561186336977548 0.207547169811321 14.2 14 2 stomach inflammation 0.834947795951328 1 0.559427132159436 0.206896551724138 14.2 14 2 increased double-positive T cell number 0.834947795951328 1 0.559427132159436 0.206896551724138 14.2 14 2 increased susceptibility to viral infection induced morbidity/mortality 0.850638948595215 1 0.55668484229591 0.205882352941176 14.2 14 2 arrested T cell differentiation 0.859083836930209 1 0.540779561087455 0.2 14.2 14 2 increased percent body fat/body weight 0.926431035917576 1 0.519980347199476 0.192307692307692 14.2 14 2 abnormal serotonin level 0.898625705474112 1 0.506980838519489 0.1875 14.2 14 2 abnormal lens fiber morphology 0.932533655489254 1 0.485314990719511 0.179487179487179 14.2 14 2 decreased pancreatic beta cell number 0.928237688360782 1 0.477158436253637 0.176470588235294 14.2 14 2 impaired natural killer cell mediated cytotoxicity 0.965672995376174 1 0.474368036041627 0.175438596491228 14.2 14 2 abnormal body temperature homeostasis 0.948352557480069 1 0.436112549264077 0.161290322580645 14.2 14 2 autoimmune response 0.948352557480069 1 0.436112549264077 0.161290322580645 14.2 14 2 decreased susceptibility to bacterial infection induced morbidity/mortality 0.948352557480069 1 0.436112549264077 0.161290322580645 14.2 14 2 impaired behavioral response to xenobiotic 0.976900904745695 1 0.386271115062468 0.142857142857143 14.2 14 2 delayed fertilization 0.000606153957032722 0.0300400268859319 3.39942938659058 1 14.1 14 1 absent sperm mitochondrial sheath 0.00294836830234048 0.0911064118269806 2.83285782215882 0.833333333333333 14.1 14 1 abnormal bile duct development 5.24723905749296e-05 0.00478671538427526 2.61494568199276 0.769230769230769 14.1 14 1 abnormal respiratory motile cilium morphology 0.000179169048478277 0.0126729549845505 2.54957203994294 0.75 14.1 14 1 pleural effusion 0.00250353719144067 0.0835912585732705 2.54957203994294 0.75 14.1 14 1 impaired mucociliary clearance 0.00250353719144067 0.0835912585732705 2.54957203994294 0.75 14.1 14 1 increased brain apoptosis 0.00250353719144067 0.0835912585732705 2.54957203994294 0.75 14.1 14 1 delayed hepatic development 0.000597499932174724 0.0300258804299925 2.47231228115679 0.727272727272727 14.1 14 1 decreased embryonic cilium length 0.000597499932174724 0.0300258804299925 2.47231228115679 0.727272727272727 14.1 14 1 increased cell nucleus count 0.00837859317578881 0.175879751263921 2.4281638475647 0.714285714285714 14.1 14 1 abnormal sperm annulus morphology 0.00837859317578881 0.175879751263921 2.4281638475647 0.714285714285714 14.1 14 1 abnormal aortic valve cusp morphology 0.00837859317578881 0.175879751263921 2.4281638475647 0.714285714285714 14.1 14 1 absent connection between subcutaneous lymph vessels and lymph sac 0.00837859317578881 0.175879751263921 2.4281638475647 0.714285714285714 14.1 14 1 abnormal sperm mitochondrial sheath morphology 9.0919571509453e-06 0.00110323138599885 2.37960057061341 0.7 14.1 14 1 abnormal sperm principal piece morphology 0.00193676692535868 0.0709932723017373 2.37960057061341 0.7 14.1 14 1 abnormal meiosis 0.000113745192070148 0.00844600493356696 2.33710770328103 0.6875 14.1 14 1 abnormal sperm midpiece morphology 7.10685332125865e-06 0.000955583656034102 2.31779276358449 0.681818181818182 14.1 14 1 abnormal male meiosis 1.63810831770444e-13 1.01869861007245e-10 2.28486237459367 0.672131147540984 14.1 14 1 impaired sperm capacitation 0.00143416169956762 0.058248212041941 2.26628625772706 0.666666666666667 14.1 14 1 abnormal vitelline vein connection 0.00143416169956762 0.058248212041941 2.26628625772706 0.666666666666667 14.1 14 1 abnormal kindling response 0.00606316933480559 0.147142768003209 2.26628625772706 0.666666666666667 14.1 14 1 arrest of spermatogenesis 7.25028339475032e-17 9.01753997222071e-14 2.22581686026764 0.654761904761905 14.1 14 1 abnormal double-strand DNA break repair 3.50116580357343e-09 1.08864374204861e-06 2.21358192615201 0.651162790697674 14.1 14 1 abnormal renal tubule epithelial cell primary cilium morphology 0.00103707328780314 0.0464814378992851 2.18534746280823 0.642857142857143 14.1 14 1 abnormal spermiogenesis 2.64447454314258e-11 1.0963550710112e-08 2.16860150523882 0.637931034482759 14.1 14 1 reduced sympathetic cervical ganglion size 0.00428048416343061 0.118128410664944 2.16327324601219 0.636363636363636 14.1 14 1 dystonia 0.000739452199534453 0.0353728335834991 2.12464336661912 0.625 14.1 14 1 abnormal vagus ganglion morphology 0.0181703531497024 0.266659312447697 2.12464336661912 0.625 14.1 14 1 elevated level of mitotic sister chromatid exchange 0.0181703531497024 0.266659312447697 2.12464336661912 0.625 14.1 14 1 binucleate 0.0181703531497024 0.266659312447697 2.12464336661912 0.625 14.1 14 1 craniofacial phenotype 0.0181703531497024 0.266659312447697 2.12464336661912 0.625 14.1 14 1 abnormal base-excision repair 0.0181703531497024 0.266659312447697 2.12464336661912 0.625 14.1 14 1 abnormal brain ependyma morphology 0.0181703531497024 0.266659312447697 2.12464336661912 0.625 14.1 14 1 abnormal hepatic vein morphology 0.0181703531497024 0.266659312447697 2.12464336661912 0.625 14.1 14 1 anomalous pulmonary venous connection 0.0181703531497024 0.266659312447697 2.12464336661912 0.625 14.1 14 1 myocardial trabeculae hypoplasia 0.0181703531497024 0.266659312447697 2.12464336661912 0.625 14.1 14 1 lethality during fetal growth through weaning, incomplete penetrance 0.0181703531497024 0.266659312447697 2.12464336661912 0.625 14.1 14 1 shortened PQ interval 0.0181703531497024 0.266659312447697 2.12464336661912 0.625 14.1 14 1 increased testis apoptosis 0.0181703531497024 0.266659312447697 2.12464336661912 0.625 14.1 14 1 abnormal fontanelle morphology 0.00207010523970397 0.0730409472874272 2.03965763195435 0.6 14.1 14 1 abnormal cerebral aqueduct morphology 0.00207010523970397 0.0730409472874272 2.03965763195435 0.6 14.1 14 1 heterochrony 0.00207010523970397 0.0730409472874272 2.03965763195435 0.6 14.1 14 1 rhinitis 0.012252772948976 0.213886124284756 2.03965763195435 0.6 14.1 14 1 abnormal respiratory conducting tube morphology 0.012252772948976 0.213886124284756 2.03965763195435 0.6 14.1 14 1 increased circulating fructosamine level 0.012252772948976 0.213886124284756 2.03965763195435 0.6 14.1 14 1 abnormal inferior vena cava valve morphology 0.012252772948976 0.213886124284756 2.03965763195435 0.6 14.1 14 1 thin ventricle myocardium compact layer 0.012252772948976 0.213886124284756 2.03965763195435 0.6 14.1 14 1 increased cellular sensitivity to ionizing radiation 6.694828302452e-05 0.0056452153906269 2.03965763195435 0.6 14.1 14 1 teratozoospermia 2.29959895563784e-13 1.27116720047758e-10 2.00875372843989 0.590909090909091 14.1 14 1 abnormal oogenesis 0.000256997112519381 0.0169486790611119 2.00875372843989 0.590909090909091 14.1 14 1 interstitial pneumonia 0.00826533561283878 0.175879751263921 1.98300047551117 0.583333333333333 14.1 14 1 decreased circulating ketone body level 0.00826533561283878 0.175879751263921 1.98300047551117 0.583333333333333 14.1 14 1 increased osteosarcoma incidence 0.00826533561283878 0.175879751263921 1.98300047551117 0.583333333333333 14.1 14 1 decreased red blood cell distribution width 0.00826533561283878 0.175879751263921 1.98300047551117 0.583333333333333 14.1 14 1 preaxial polydactyly 2.33206159337255e-05 0.00246851200575073 1.97386222447195 0.580645161290323 14.1 14 1 abnormal female meiosis 5.68044289954628e-08 1.22870449674968e-05 1.96120926149457 0.576923076923077 14.1 14 1 increased hemangioma incidence 0.00558466688626568 0.142290072197083 1.94253107805176 0.571428571428571 14.1 14 1 abnormal ventral body wall morphology 0.00558466688626568 0.142290072197083 1.94253107805176 0.571428571428571 14.1 14 1 split sternum 0.00558466688626568 0.142290072197083 1.94253107805176 0.571428571428571 14.1 14 1 abnormal respiratory motile cilium physiology 0.00558466688626568 0.142290072197083 1.94253107805176 0.571428571428571 14.1 14 1 decreased liver cholesterol level 0.00378094486277907 0.108104601680034 1.9121790299572 0.5625 14.1 14 1 embryonic lethality between somite formation and embryo turning, incomplete penetrance 0.00378094486277907 0.108104601680034 1.9121790299572 0.5625 14.1 14 1 abnormal eye muscle morphology 0.00022213707845689 0.015138794045521 1.88857188143921 0.555555555555556 14.1 14 1 abnormal sperm axoneme morphology 0.00256494997764841 0.0850708409253391 1.88857188143921 0.555555555555556 14.1 14 1 abnormal NMDA-mediated synaptic currents 0.0333043329183234 0.396385302078131 1.88857188143921 0.555555555555556 14.1 14 1 abnormal artery development 0.0333043329183234 0.396385302078131 1.88857188143921 0.555555555555556 14.1 14 1 decreased cellular sensitivity to ionizing radiation 0.0333043329183234 0.396385302078131 1.88857188143921 0.555555555555556 14.1 14 1 increased neuronal precursor cell number 0.0333043329183234 0.396385302078131 1.88857188143921 0.555555555555556 14.1 14 1 abnormal optic chiasm morphology 0.0333043329183234 0.396385302078131 1.88857188143921 0.555555555555556 14.1 14 1 multiflagellated sperm 0.0333043329183234 0.396385302078131 1.88857188143921 0.555555555555556 14.1 14 1 abnormal lung lobe morphology 0.0333043329183234 0.396385302078131 1.88857188143921 0.555555555555556 14.1 14 1 increased core body temperature 0.0333043329183234 0.396385302078131 1.88857188143921 0.555555555555556 14.1 14 1 abnormal infrahyoid muscle connection 0.0333043329183234 0.396385302078131 1.88857188143921 0.555555555555556 14.1 14 1 symmetric azygos veins 0.0333043329183234 0.396385302078131 1.88857188143921 0.555555555555556 14.1 14 1 increased mortality induced by gamma-irradiation 0.000153056394930805 0.0111978759526582 1.87554724777412 0.551724137931034 14.1 14 1 spleen atrophy 0.00174336238982237 0.0659686231783173 1.86968616262482 0.55 14.1 14 1 abnormal glossopharyngeal ganglion morphology 0.0218195194916304 0.305780590058764 1.85423421086759 0.545454545454545 14.1 14 1 abnormal eye distance/ position 0.0218195194916304 0.305780590058764 1.85423421086759 0.545454545454545 14.1 14 1 loss of cortex neurons 0.0218195194916304 0.305780590058764 1.85423421086759 0.545454545454545 14.1 14 1 ventricular hypoplasia 0.000552905820132355 0.029024743821113 1.83046197739493 0.538461538461538 14.1 14 1 absent myocardial trabeculae 0.0144245115261491 0.236838101790731 1.83046197739493 0.538461538461538 14.1 14 1 increased foot pad pigmentation 0.0144245115261491 0.236838101790731 1.83046197739493 0.538461538461538 14.1 14 1 abnormal coping response 0.0144245115261491 0.236838101790731 1.83046197739493 0.538461538461538 14.1 14 1 axonal dystrophy 0.0144245115261491 0.236838101790731 1.83046197739493 0.538461538461538 14.1 14 1 increased circulating thyroxine level 0.0144245115261491 0.236838101790731 1.83046197739493 0.538461538461538 14.1 14 1 absent hypoglossal nerve 0.0144245115261491 0.236838101790731 1.83046197739493 0.538461538461538 14.1 14 1 subcutaneous edema 0.000378130073358307 0.022395203749495 1.82112288567353 0.535714285714286 14.1 14 1 abnormal heart tube morphology 0.0002589144941999 0.0169486790611119 1.81302900618165 0.533333333333333 14.1 14 1 abnormal apical ectodermal ridge morphology 0.0096013087680505 0.194965351514495 1.81302900618165 0.533333333333333 14.1 14 1 delayed intramembranous bone ossification 0.0096013087680505 0.194965351514495 1.81302900618165 0.533333333333333 14.1 14 1 abnormal placenta size 0.0096013087680505 0.194965351514495 1.81302900618165 0.533333333333333 14.1 14 1 immune system phenotype 0.0096013087680505 0.194965351514495 1.81302900618165 0.533333333333333 14.1 14 1 abnormal cell nucleus morphology 5.44631806270548e-06 0.000774155210341707 1.80820712052691 0.531914893617021 14.1 14 1 abnormal adipose tissue morphology 0.00642541007230519 0.152221024331992 1.79969791054796 0.529411764705882 14.1 14 1 abnormal interatrial septum morphology 0.00642541007230519 0.152221024331992 1.79969791054796 0.529411764705882 14.1 14 1 azoospermia 1.43145065947693e-16 1.42429340617955e-13 1.79592495895352 0.528301886792453 14.1 14 1 left pulmonary isomerism 0.00291334563512702 0.0911064118269806 1.78065348821412 0.523809523809524 14.1 14 1 abnormal gametogenesis 1.87537039898642e-05 0.00202825385542553 1.77697445208144 0.522727272727273 14.1 14 1 abnormal heart valve morphology 0.000909118311167466 0.0415904190413084 1.76266708934327 0.518518518518518 14.1 14 1 inner cell mass degeneration 0.000422564481970657 0.0244448639279537 1.75454419953062 0.516129032258065 14.1 14 1 impaired fertilization 1.53869230040957e-07 3.18958091439068e-05 1.74827797024659 0.514285714285714 14.1 14 1 male infertility 1.18501430787366e-42 5.89544618167147e-39 1.71661046559445 0.504970178926441 14.1 14 1 increased hemangiosarcoma incidence 0.00313288280246457 0.0950371459893979 1.69971469329529 0.5 14.1 14 1 abnormal truncus arteriosus septation 0.00313288280246457 0.0950371459893979 1.69971469329529 0.5 14.1 14 1 abnormal thymus involution 0.0353737033704219 0.400817067946116 1.69971469329529 0.5 14.1 14 1 abnormal embryonic growth/weight/body size 0.0353737033704219 0.400817067946116 1.69971469329529 0.5 14.1 14 1 abnormal alisphenoid bone morphology 0.0353737033704219 0.400817067946116 1.69971469329529 0.5 14.1 14 1 loss of dopaminergic neurons 0.0353737033704219 0.400817067946116 1.69971469329529 0.5 14.1 14 1 absent ovary 0.0353737033704219 0.400817067946116 1.69971469329529 0.5 14.1 14 1 abnormal somatic nervous system physiology 0.0353737033704219 0.400817067946116 1.69971469329529 0.5 14.1 14 1 decreased mammary gland epithelial cell proliferation 0.0353737033704219 0.400817067946116 1.69971469329529 0.5 14.1 14 1 embryonic lethality between implantation and placentation, incomplete penetrance 0.0353737033704219 0.400817067946116 1.69971469329529 0.5 14.1 14 1 liver hypoplasia 1.54313479071063e-05 0.00170602124084119 1.69971469329529 0.5 14.1 14 1 abnormal mitotic spindle morphology 0.00144010654897663 0.058248212041941 1.69971469329529 0.5 14.1 14 1 abnormal enterocyte morphology 0.00463965703827737 0.126132752816557 1.69971469329529 0.5 14.1 14 1 small gonad 0.0068942664216116 0.155761099126269 1.69971469329529 0.5 14.1 14 1 increased mammary adenocarcinoma incidence 0.0068942664216116 0.155761099126269 1.69971469329529 0.5 14.1 14 1 abnormal male reproductive system physiology 0.0068942664216116 0.155761099126269 1.69971469329529 0.5 14.1 14 1 absent ductus venosus valve 0.0068942664216116 0.155761099126269 1.69971469329529 0.5 14.1 14 1 underdeveloped hair follicles 0.010285870166962 0.199891422189983 1.69971469329529 0.5 14.1 14 1 eye inflammation 0.010285870166962 0.199891422189983 1.69971469329529 0.5 14.1 14 1 abnormal bile duct morphology 0.010285870166962 0.199891422189983 1.69971469329529 0.5 14.1 14 1 darkened coat color 0.010285870166962 0.199891422189983 1.69971469329529 0.5 14.1 14 1 decreased lactate dehydrogenase level 0.010285870166962 0.199891422189983 1.69971469329529 0.5 14.1 14 1 abnormal hypoglossal nerve topology 0.010285870166962 0.199891422189983 1.69971469329529 0.5 14.1 14 1 irregularly shaped pupil 0.0232643561660325 0.319015874168928 1.69971469329529 0.5 14.1 14 1 failure of zygotic cell division 0.0232643561660325 0.319015874168928 1.69971469329529 0.5 14.1 14 1 abnormal neuron specification 0.0543558928876708 0.467855652450107 1.69971469329529 0.5 14.1 14 1 acrania 0.0543558928876708 0.467855652450107 1.69971469329529 0.5 14.1 14 1 increased heart rate variability 0.0543558928876708 0.467855652450107 1.69971469329529 0.5 14.1 14 1 abnormal embryonic erythrocyte morphology 0.0543558928876708 0.467855652450107 1.69971469329529 0.5 14.1 14 1 ascites 0.0543558928876708 0.467855652450107 1.69971469329529 0.5 14.1 14 1 umbilical hernia 0.0543558928876708 0.467855652450107 1.69971469329529 0.5 14.1 14 1 acanthocytosis 0.0543558928876708 0.467855652450107 1.69971469329529 0.5 14.1 14 1 abnormal left subclavian artery morphology 0.0543558928876708 0.467855652450107 1.69971469329529 0.5 14.1 14 1 intraventricular hemorrhage 0.015421672673322 0.245708820982997 1.69971469329529 0.5 14.1 14 1 small pancreas 0.015421672673322 0.245708820982997 1.69971469329529 0.5 14.1 14 1 blepharitis 0.015421672673322 0.245708820982997 1.69971469329529 0.5 14.1 14 1 abnormal fertilization 0.015421672673322 0.245708820982997 1.69971469329529 0.5 14.1 14 1 decreased midbrain size 0.015421672673322 0.245708820982997 1.69971469329529 0.5 14.1 14 1 small ovary 2.16380919588833e-08 5.38247537477222e-06 1.68103650985249 0.494505494505495 14.1 14 1 incomplete embryo turning 1.12963410315104e-05 0.00133807849123248 1.66989513727257 0.491228070175439 14.1 14 1 short sternum 0.00220621091445957 0.0767545405554989 1.64110384180235 0.482758620689655 14.1 14 1 decreased oocyte number 7.56430610624273e-05 0.00616924965222256 1.63172610556348 0.48 14.1 14 1 dilated heart 0.00708573163190412 0.157372834235371 1.62581405445637 0.478260869565217 14.1 14 1 absent segment of posterior cerebral artery 0.0105132853184157 0.20272711030666 1.61877589837647 0.476190476190476 14.1 14 1 small testis 1.21746903312675e-19 2.0189694799352e-16 1.61349728131655 0.47463768115942 14.1 14 1 kyphoscoliosis 0.0156562203520825 0.245708820982997 1.61025602522712 0.473684210526316 14.1 14 1 abnormal stationary movement 0.0156562203520825 0.245708820982997 1.61025602522712 0.473684210526316 14.1 14 1 decreased germ cell number 0.0156562203520825 0.245708820982997 1.61025602522712 0.473684210526316 14.1 14 1 abnormal digestive system development 0.0156562203520825 0.245708820982997 1.61025602522712 0.473684210526316 14.1 14 1 right-sided stomach 0.0156562203520825 0.245708820982997 1.61025602522712 0.473684210526316 14.1 14 1 pericardial edema 8.64456833302599e-06 0.00109522603168566 1.59973147604263 0.470588235294118 14.1 14 1 abnormal involuntary movement 0.0234183505408924 0.319015874168928 1.59973147604263 0.470588235294118 14.1 14 1 abnormal ectoplacental cone morphology 0.0234183505408924 0.319015874168928 1.59973147604263 0.470588235294118 14.1 14 1 delayed heart development 0.0234183505408924 0.319015874168928 1.59973147604263 0.470588235294118 14.1 14 1 abnormal rostral migratory stream morphology 0.0352195226392666 0.400817067946116 1.58640038040894 0.466666666666667 14.1 14 1 decreased thymocyte apoptosis 0.0352195226392666 0.400817067946116 1.58640038040894 0.466666666666667 14.1 14 1 astrocytosis 6.08357194795733e-06 0.000840715845585769 1.58329587868603 0.465753424657534 14.1 14 1 abnormal cell morphology 1.91876952974054e-08 5.02414653182063e-06 1.58043646920439 0.464912280701754 14.1 14 1 rib bifurcation 0.00481343385118623 0.128746416180922 1.57830650091706 0.464285714285714 14.1 14 1 small superior cervical ganglion 0.00481343385118623 0.128746416180922 1.57830650091706 0.464285714285714 14.1 14 1 premature aging 0.00481343385118623 0.128746416180922 1.57830650091706 0.464285714285714 14.1 14 1 heart inflammation 0.00707812346472532 0.157372834235371 1.56896740919565 0.461538461538462 14.1 14 1 abnormal tail bud morphology 0.0533301535226559 0.466619281827541 1.56896740919565 0.461538461538462 14.1 14 1 empty decidua capsularis 0.0533301535226559 0.466619281827541 1.56896740919565 0.461538461538462 14.1 14 1 small seminiferous tubules 8.80583744068872e-06 0.00109522603168566 1.56189998843351 0.459459459459459 14.1 14 1 small heart 0.000342694628585258 0.0207915338684349 1.55807180218735 0.458333333333333 14.1 14 1 abnormal impulse conducting system conduction 0.0104304498721991 0.201912405113582 1.55807180218735 0.458333333333333 14.1 14 1 increased carcinoma incidence 0.00222848971213116 0.0769912244295313 1.55402486244141 0.457142857142857 14.1 14 1 embryonic lethality between implantation and placentation, complete penetrance 0.000496060745587569 0.0268250240141104 1.55191341561744 0.456521739130435 14.1 14 1 intracerebral hemorrhage 0.0154079755518644 0.245708820982997 1.54519517572299 0.454545454545455 14.1 14 1 increased mammary gland tumor incidence 0.0154079755518644 0.245708820982997 1.54519517572299 0.454545454545455 14.1 14 1 premature suture closure 0.081469537384371 0.604452447357692 1.54519517572299 0.454545454545455 14.1 14 1 abnormal awl hair morphology 0.081469537384371 0.604452447357692 1.54519517572299 0.454545454545455 14.1 14 1 failure of somite differentiation 0.081469537384371 0.604452447357692 1.54519517572299 0.454545454545455 14.1 14 1 abnormal vestibular ganglion morphology 0.081469537384371 0.604452447357692 1.54519517572299 0.454545454545455 14.1 14 1 fatigue 0.081469537384371 0.604452447357692 1.54519517572299 0.454545454545455 14.1 14 1 abnormal lymph circulation 0.081469537384371 0.604452447357692 1.54519517572299 0.454545454545455 14.1 14 1 abnormal coronal suture morphology 0.081469537384371 0.604452447357692 1.54519517572299 0.454545454545455 14.1 14 1 pharyngeal arch hypoplasia 0.081469537384371 0.604452447357692 1.54519517572299 0.454545454545455 14.1 14 1 abnormal superovulation 0.081469537384371 0.604452447357692 1.54519517572299 0.454545454545455 14.1 14 1 thin hypoglossal nerve 0.081469537384371 0.604452447357692 1.54519517572299 0.454545454545455 14.1 14 1 abnormal optic stalk morphology 0.0228250917497404 0.318080760378035 1.52974322396576 0.45 14.1 14 1 decreased circulating creatinine level 0.000489366280878053 0.0268250240141104 1.52627441846924 0.448979591836735 14.1 14 1 abnormal trophoblast giant cell morphology 0.00317389175191499 0.095203512142523 1.51085750515137 0.444444444444444 14.1 14 1 abnormal metacarpal bone morphology 0.0339243348400367 0.398050862804676 1.51085750515137 0.444444444444444 14.1 14 1 abnormal eye anterior chamber morphology 0.0339243348400367 0.398050862804676 1.51085750515137 0.444444444444444 14.1 14 1 jerky movement 0.0339243348400367 0.398050862804676 1.51085750515137 0.444444444444444 14.1 14 1 abnormal glycogen homeostasis 0.0339243348400367 0.398050862804676 1.51085750515137 0.444444444444444 14.1 14 1 primary atelectasis 0.0339243348400367 0.398050862804676 1.51085750515137 0.444444444444444 14.1 14 1 abnormal oocyte morphology 0.00460736777318212 0.12594315753616 1.49974825878996 0.441176470588235 14.1 14 1 scoliosis 0.00669187432509759 0.155570442838133 1.48725035663338 0.4375 14.1 14 1 vasculature congestion 0.0506178503905569 0.45813555528897 1.48725035663338 0.4375 14.1 14 1 disorganized yolk sac vascular plexus 0.0506178503905569 0.45813555528897 1.48725035663338 0.4375 14.1 14 1 abnormal epicardium morphology 0.0506178503905569 0.45813555528897 1.48725035663338 0.4375 14.1 14 1 abnormal ovary morphology 7.28051686119207e-05 0.00603676189740509 1.48425790118744 0.436619718309859 14.1 14 1 abnormal cell death 0.00142141937786183 0.058248212041941 1.47801277677852 0.434782608695652 14.1 14 1 abnormal sacral vertebrae morphology 0.0218097016441415 0.305780590058764 1.47801277677852 0.434782608695652 14.1 14 1 abnormal hematopoietic stem cell physiology 0.0218097016441415 0.305780590058764 1.47801277677852 0.434782608695652 14.1 14 1 muscular ventricular septal defect 0.000313006314469403 0.0197114736010795 1.47308606752259 0.433333333333333 14.1 14 1 embryonic lethality before implantation, complete penetrance 2.92401575738365e-07 5.81879135719347e-05 1.46855349500713 0.432 14.1 14 1 increased sarcoma incidence 0.00136339772458982 0.0569991905868432 1.45689830853882 0.428571428571429 14.1 14 1 abnormal optic nerve morphology 0.00293552504541657 0.0911064118269806 1.45689830853882 0.428571428571429 14.1 14 1 abnormal salivary gland morphology 0.0320589465732339 0.396385302078131 1.45689830853882 0.428571428571429 14.1 14 1 abnormal bile salt homeostasis 0.0320589465732339 0.396385302078131 1.45689830853882 0.428571428571429 14.1 14 1 abnormal imprinting 0.0758795015401235 0.599207174860499 1.45689830853882 0.428571428571429 14.1 14 1 abnormal squamosal bone morphology 0.0758795015401235 0.599207174860499 1.45689830853882 0.428571428571429 14.1 14 1 decreased tongue size 0.0758795015401235 0.599207174860499 1.45689830853882 0.428571428571429 14.1 14 1 multiple persisting craniopharyngeal ducts 0.0758795015401235 0.599207174860499 1.45689830853882 0.428571428571429 14.1 14 1 increased tumor incidence 5.6350263602661e-07 9.902034415346e-05 1.4529819152363 0.42741935483871 14.1 14 1 impaired limb coordination 0.000911227271457812 0.0415904190413084 1.4479051091034 0.425925925925926 14.1 14 1 dextrocardia 0.00922835326919377 0.191296072975996 1.44218216400813 0.424242424242424 14.1 14 1 increased hemoglobin content 0.00060985783225711 0.0300400268859319 1.44043618075872 0.423728813559322 14.1 14 1 increased embryonic tissue cell apoptosis 9.2017060772563e-05 0.00726642662450001 1.43822012509602 0.423076923076923 14.1 14 1 distended pericardium 0.00129973107747338 0.0552663428241885 1.43822012509602 0.423076923076923 14.1 14 1 abnormal myocardial trabeculae morphology 0.00279112966428962 0.0895862585796184 1.4353146298938 0.422222222222222 14.1 14 1 decreased tumor incidence 0.0472102362858218 0.45813555528897 1.43133868909077 0.421052631578947 14.1 14 1 decreased fertilization frequency 0.0472102362858218 0.45813555528897 1.43133868909077 0.421052631578947 14.1 14 1 decreased circulating magnesium level 0.0472102362858218 0.45813555528897 1.43133868909077 0.421052631578947 14.1 14 1 abnormal mitochondrial ATP synthesis coupled electron transport 0.0133224948722075 0.226984287634357 1.42556716211863 0.419354838709677 14.1 14 1 abnormal embryo turning 0.00123267480286799 0.0533265838632021 1.42157956166515 0.418181818181818 14.1 14 1 abnormal cell cycle 4.20577598430914e-06 0.000645389631199828 1.41889226570737 0.417391304347826 14.1 14 1 abnormal tracheal ciliated epithelium morphology 0.114395133108621 0.71861123143697 1.41642891107941 0.416666666666667 14.1 14 1 abnormal AMPA-mediated synaptic currents 0.114395133108621 0.71861123143697 1.41642891107941 0.416666666666667 14.1 14 1 decreased synaptic depression 0.114395133108621 0.71861123143697 1.41642891107941 0.416666666666667 14.1 14 1 small intestinal inflammation 0.114395133108621 0.71861123143697 1.41642891107941 0.416666666666667 14.1 14 1 abnormal vascular endothelial cell development 0.114395133108621 0.71861123143697 1.41642891107941 0.416666666666667 14.1 14 1 abnormal rostral-caudal body axis extension 0.114395133108621 0.71861123143697 1.41642891107941 0.416666666666667 14.1 14 1 reduced cerebellar foliation 0.114395133108621 0.71861123143697 1.41642891107941 0.416666666666667 14.1 14 1 increased fibrosarcoma incidence 0.114395133108621 0.71861123143697 1.41642891107941 0.416666666666667 14.1 14 1 abnormal pulmonary valve cusp morphology 0.114395133108621 0.71861123143697 1.41642891107941 0.416666666666667 14.1 14 1 abnormal colon goblet cell morphology 0.114395133108621 0.71861123143697 1.41642891107941 0.416666666666667 14.1 14 1 abnormal lysosome morphology 0.0086898367240099 0.180886768627403 1.41642891107941 0.416666666666667 14.1 14 1 abnormal mesoderm development 0.00175032326824882 0.0659686231783173 1.41108389632062 0.415094339622642 14.1 14 1 abnormal cell differentiation 0.00569959157207584 0.142290072197083 1.40951950175707 0.414634146341463 14.1 14 1 increased mean corpuscular hemoglobin 2.54932202503465e-05 0.00264226605719737 1.4078444934365 0.414141414141414 14.1 14 1 lordosis 0.0192279157459135 0.279704329929589 1.40666043583059 0.413793103448276 14.1 14 1 decreased trophoblast giant cell number 0.0192279157459135 0.279704329929589 1.40666043583059 0.413793103448276 14.1 14 1 blood in lymph vessels 0.0192279157459135 0.279704329929589 1.40666043583059 0.413793103448276 14.1 14 1 abnormal nervous system development 0.012463043116402 0.215290414944792 1.3997650415373 0.411764705882353 14.1 14 1 abnormal direction of heart looping 0.012463043116402 0.215290414944792 1.3997650415373 0.411764705882353 14.1 14 1 abnormal cranial suture morphology 0.0696575002853224 0.566632474376444 1.3997650415373 0.411764705882353 14.1 14 1 increased brain size 0.0696575002853224 0.566632474376444 1.3997650415373 0.411764705882353 14.1 14 1 coloboma 0.0696575002853224 0.566632474376444 1.3997650415373 0.411764705882353 14.1 14 1 increased hepatoma incidence 0.0696575002853224 0.566632474376444 1.3997650415373 0.411764705882353 14.1 14 1 abnormal electroretinogram waveform feature 0.0696575002853224 0.566632474376444 1.3997650415373 0.411764705882353 14.1 14 1 abnormal seminiferous tubule morphology 5.3891635060005e-07 9.902034415346e-05 1.3970257753112 0.410958904109589 14.1 14 1 abnormal heart looping 0.00813435554668035 0.175879751263921 1.3946376970628 0.41025641025641 14.1 14 1 abnormal neural tube closure 0.000155669789766474 0.0112240174505537 1.3925373390853 0.409638554216867 14.1 14 1 lethality, incomplete penetrance 0.00533798721468569 0.139770981016112 1.39067565815069 0.409090909090909 14.1 14 1 abnormal abdominal fat pad morphology 0.0435865418957205 0.444350503957397 1.39067565815069 0.409090909090909 14.1 14 1 abnormal facial nerve morphology 0.0435865418957205 0.444350503957397 1.39067565815069 0.409090909090909 14.1 14 1 testis hypoplasia 0.0435865418957205 0.444350503957397 1.39067565815069 0.409090909090909 14.1 14 1 increased skin papilloma incidence 0.0435865418957205 0.444350503957397 1.39067565815069 0.409090909090909 14.1 14 1 embryonic lethality before implantation, incomplete penetrance 0.0435865418957205 0.444350503957397 1.39067565815069 0.409090909090909 14.1 14 1 abnormal craniofacial development 0.00351825306569808 0.102358532174549 1.3875221986084 0.408163265306122 14.1 14 1 abnormal spermatogenesis 3.35106007364497e-08 7.93882088875415e-06 1.38563697822986 0.407608695652174 14.1 14 1 neurodegeneration 0.00232720176604263 0.0798470950762901 1.38495271305542 0.407407407407407 14.1 14 1 decreased susceptibility to pharmacologically induced seizures 0.0277386417071865 0.351144382934486 1.38495271305542 0.407407407407407 14.1 14 1 increased grip strength 9.83196597521258e-05 0.00752523549641271 1.3821855747676 0.406593406593407 14.1 14 1 disheveled coat 0.00757915681020418 0.167583578358959 1.37595951362 0.404761904761905 14.1 14 1 abnormal hippocampus pyramidal cell morphology 0.0165107209813564 0.256690115257025 1.35977175463623 0.4 14.1 14 1 abnormal synaptic transmission 0.0255633434476049 0.340958803356125 1.35977175463623 0.4 14.1 14 1 spontaneous skin ulceration 0.0399883081031775 0.421318258155141 1.35977175463623 0.4 14.1 14 1 abnormal nest building behavior 0.0399883081031775 0.421318258155141 1.35977175463623 0.4 14.1 14 1 abnormal energy expenditure 0.0399883081031775 0.421318258155141 1.35977175463623 0.4 14.1 14 1 abnormal vascular regression 0.0634669993098759 0.525371583305545 1.35977175463623 0.4 14.1 14 1 abnormal postnatal subventricular zone morphology 0.0634669993098759 0.525371583305545 1.35977175463623 0.4 14.1 14 1 abnormal neuron proliferation 0.0634669993098759 0.525371583305545 1.35977175463623 0.4 14.1 14 1 macrocytosis 0.102986154140695 0.698985152592028 1.35977175463623 0.4 14.1 14 1 abnormal pup retrieval 0.102986154140695 0.698985152592028 1.35977175463623 0.4 14.1 14 1 decreased brown adipose tissue mass 0.102986154140695 0.698985152592028 1.35977175463623 0.4 14.1 14 1 embryonic lethality between implantation and somite formation, complete penetrance 9.76587321640536e-10 3.23901461677445e-07 1.35977175463623 0.4 14.1 14 1 abnormal excitatory postsynaptic currents 0.000557047367966475 0.029024743821113 1.35105526902959 0.397435897435897 14.1 14 1 decreased circulating alanine transaminase level 0.00125176740118873 0.053685713973396 1.34977343291097 0.397058823529412 14.1 14 1 thymus atrophy 0.00651223208718759 0.152822427517728 1.34560746552544 0.395833333333333 14.1 14 1 abnormal left-right axis patterning 0.00992590580689902 0.199891422189983 1.34396045516372 0.395348837209302 14.1 14 1 delayed endochondral bone ossification 0.00992590580689902 0.199891422189983 1.34396045516372 0.395348837209302 14.1 14 1 increased neuron apoptosis 0.000518074361521116 0.02771419299535 1.34298444902344 0.395061728395062 14.1 14 1 cardiovascular system phenotype 0.0234693085318247 0.319015874168928 1.33916915229326 0.393939393939394 14.1 14 1 abnormal somite shape 0.0365378476540146 0.40940493711424 1.33549011616059 0.392857142857143 14.1 14 1 failure of blastocyst to hatch from the zona pellucida 0.0365378476540146 0.40940493711424 1.33549011616059 0.392857142857143 14.1 14 1 abnormal renal tubule epithelium morphology 0.0365378476540146 0.40940493711424 1.33549011616059 0.392857142857143 14.1 14 1 prolonged QRS complex duration 0.0365378476540146 0.40940493711424 1.33549011616059 0.392857142857143 14.1 14 1 increased lung adenocarcinoma incidence 0.0060130099638866 0.146640806717332 1.33310956336886 0.392156862745098 14.1 14 1 failure of chorioallantoic fusion 0.0060130099638866 0.146640806717332 1.33310956336886 0.392156862745098 14.1 14 1 abnormal chondrocyte physiology 0.0575859392003069 0.488058002592039 1.33021149910066 0.391304347826087 14.1 14 1 abnormal hepatocyte physiology 0.0575859392003069 0.488058002592039 1.33021149910066 0.391304347826087 14.1 14 1 abnormal vertebral artery topology 0.0575859392003069 0.488058002592039 1.33021149910066 0.391304347826087 14.1 14 1 microcephaly 0.00161639968990508 0.062337895017657 1.33021149910066 0.391304347826087 14.1 14 1 impaired wound healing 0.0214876473269404 0.305780590058764 1.32200031700745 0.388888888888889 14.1 14 1 abnormal pharyngeal arch morphology 0.0214876473269404 0.305780590058764 1.32200031700745 0.388888888888889 14.1 14 1 abnormal heart shape 0.0923967873868674 0.642900723426106 1.32200031700745 0.388888888888889 14.1 14 1 abnormal phrenic nerve morphology 0.0923967873868674 0.642900723426106 1.32200031700745 0.388888888888889 14.1 14 1 decreased cellular sensitivity to gamma-irradiation 0.0923967873868674 0.642900723426106 1.32200031700745 0.388888888888889 14.1 14 1 abnormal body wall morphology 0.0923967873868674 0.642900723426106 1.32200031700745 0.388888888888889 14.1 14 1 increased circulating glycerol level 0.0923967873868674 0.642900723426106 1.32200031700745 0.388888888888889 14.1 14 1 long tibia 0.0923967873868674 0.642900723426106 1.32200031700745 0.388888888888889 14.1 14 1 decreased pulmonary respiratory rate 0.0923967873868674 0.642900723426106 1.32200031700745 0.388888888888889 14.1 14 1 small thoracic cage 0.0923967873868674 0.642900723426106 1.32200031700745 0.388888888888889 14.1 14 1 increased effector memory CD8-positive, alpha-beta T cell number 0.0923967873868674 0.642900723426106 1.32200031700745 0.388888888888889 14.1 14 1 reduced male fertility 3.86025585583103e-08 8.72944221943609e-06 1.31784046704833 0.387665198237885 14.1 14 1 absent mature ovarian follicles 0.0332944057057508 0.396385302078131 1.31590814964797 0.387096774193548 14.1 14 1 increased lung adenoma incidence 0.0332944057057508 0.396385302078131 1.31590814964797 0.387096774193548 14.1 14 1 decreased neuronal precursor cell number 0.0332944057057508 0.396385302078131 1.31590814964797 0.387096774193548 14.1 14 1 small cranium 0.0332944057057508 0.396385302078131 1.31590814964797 0.387096774193548 14.1 14 1 omphalocele 0.0128145952908852 0.219081139423209 1.31341589936454 0.386363636363636 14.1 14 1 decreased brain weight 0.00509770573251405 0.135620780851644 1.31206046499987 0.385964912280702 14.1 14 1 embryonic lethality between somite formation and embryo turning, complete penetrance 0.00206870663665247 0.0730409472874272 1.31120847768494 0.385714285714286 14.1 14 1 increased leukemia incidence 0.0521247658163868 0.460605168626153 1.30747284099638 0.384615384615385 14.1 14 1 increased thymocyte apoptosis 0.0521247658163868 0.460605168626153 1.30747284099638 0.384615384615385 14.1 14 1 abnormal renal/urinary system morphology 0.152560745349848 0.740555644741389 1.30747284099638 0.384615384615385 14.1 14 1 excessive scratching 0.152560745349848 0.740555644741389 1.30747284099638 0.384615384615385 14.1 14 1 increased pituitary adenoma incidence 0.152560745349848 0.740555644741389 1.30747284099638 0.384615384615385 14.1 14 1 dystrophic cardiac calcinosis 0.152560745349848 0.740555644741389 1.30747284099638 0.384615384615385 14.1 14 1 abnormal vertebral arch development 0.152560745349848 0.740555644741389 1.30747284099638 0.384615384615385 14.1 14 1 orthokeratosis 0.152560745349848 0.740555644741389 1.30747284099638 0.384615384615385 14.1 14 1 decreased bone trabecula number 0.0117308741246123 0.210101261145482 1.30190912677937 0.382978723404255 14.1 14 1 abnormal brown adipose tissue morphology 0.0302827109318483 0.379487372508678 1.29978182428464 0.382352941176471 14.1 14 1 decreased susceptibility to hepatic steatosis 0.00429773715183012 0.118128410664944 1.29502071870118 0.380952380952381 14.1 14 1 abnormal reproductive system morphology 0.0179121716907778 0.266659312447697 1.29502071870118 0.380952380952381 14.1 14 1 spina bifida 0.0179121716907778 0.266659312447697 1.29502071870118 0.380952380952381 14.1 14 1 increased keratinocyte proliferation 0.0827950317631939 0.604452447357692 1.29502071870118 0.380952380952381 14.1 14 1 decreased heart rate 0.000411860976536401 0.0241059806855129 1.29178316690442 0.38 14.1 14 1 abnormal placenta labyrinth morphology 0.00161034241105759 0.062337895017657 1.29092255186984 0.379746835443038 14.1 14 1 abnormal visceral yolk sac morphology 0.00161034241105759 0.062337895017657 1.29092255186984 0.379746835443038 14.1 14 1 abnormal nervous system morphology 0.00161034241105759 0.062337895017657 1.29092255186984 0.379746835443038 14.1 14 1 abnormal vascular development 0.00393997160593423 0.110742139771315 1.28766264643583 0.378787878787879 14.1 14 1 increased brown adipose tissue amount 0.0275082784661137 0.351144382934486 1.28627057870995 0.378378378378378 14.1 14 1 increased erythroid progenitor cell number 0.0275082784661137 0.351144382934486 1.28627057870995 0.378378378378378 14.1 14 1 abnormal chromosome morphology 0.0275082784661137 0.351144382934486 1.28627057870995 0.378378378378378 14.1 14 1 abnormal respiratory electron transport chain 0.0275082784661137 0.351144382934486 1.28627057870995 0.378378378378378 14.1 14 1 prenatal lethality, complete penetrance 1.03271405702118e-08 2.85430690760021e-06 1.28395714241731 0.377697841726619 14.1 14 1 increased double-negative T cell number 0.00592693486162047 0.145972776913672 1.28175206379645 0.377049180327869 14.1 14 1 abnormal neural tube morphology 1.27414346524046e-05 0.00147415435803984 1.28003205297547 0.376543209876543 14.1 14 1 decreased body height 0.0741748595460307 0.589488700066298 1.27478601997147 0.375 14.1 14 1 ocular hypertelorism 0.0741748595460307 0.589488700066298 1.27478601997147 0.375 14.1 14 1 abnormal tumor morphology 0.0741748595460307 0.589488700066298 1.27478601997147 0.375 14.1 14 1 increased body temperature 0.0741748595460307 0.589488700066298 1.27478601997147 0.375 14.1 14 1 increased circulating total protein level 0.0741748595460307 0.589488700066298 1.27478601997147 0.375 14.1 14 1 abnormal female reproductive system morphology 0.0249659455743148 0.336050612804925 1.27478601997147 0.375 14.1 14 1 decreased caudal vertebrae number 0.00541796622292941 0.141122418633894 1.27478601997147 0.375 14.1 14 1 polydipsia 0.0425555079812735 0.439239942337833 1.27478601997147 0.375 14.1 14 1 increased circulating follicle stimulating hormone level 0.0425555079812735 0.439239942337833 1.27478601997147 0.375 14.1 14 1 increased fatty acid level 0.0425555079812735 0.439239942337833 1.27478601997147 0.375 14.1 14 1 increased fibroblast apoptosis 0.0425555079812735 0.439239942337833 1.27478601997147 0.375 14.1 14 1 abnormal bone marrow cell number 0.134407136390777 0.71861123143697 1.27478601997147 0.375 14.1 14 1 increased intestinal adenocarcinoma incidence 0.134407136390777 0.71861123143697 1.27478601997147 0.375 14.1 14 1 increased cochlear outer hair cell number 0.134407136390777 0.71861123143697 1.27478601997147 0.375 14.1 14 1 abnormal amnion morphology 0.134407136390777 0.71861123143697 1.27478601997147 0.375 14.1 14 1 impaired somite development 0.134407136390777 0.71861123143697 1.27478601997147 0.375 14.1 14 1 abnormal urinary bladder physiology 0.134407136390777 0.71861123143697 1.27478601997147 0.375 14.1 14 1 preweaning lethality, complete penetrance 5.71010286925199e-20 1.42038808872643e-16 1.27248910822377 0.374324324324324 14.1 14 1 spleen hyperplasia 0.00302183500974066 0.092800180083085 1.26912030432715 0.373333333333333 14.1 14 1 syndactyly 0.00815207111419853 0.175879751263921 1.26758383906768 0.372881355932203 14.1 14 1 small liver 0.00276280434981504 0.0892529327294145 1.26389041296317 0.371794871794872 14.1 14 1 increased circulating alanine transaminase level 0.00276280434981504 0.0892529327294145 1.26389041296317 0.371794871794872 14.1 14 1 embryonic lethality during organogenesis, complete penetrance 6.19599004068784e-15 4.40357863606028e-12 1.26264520073365 0.371428571428571 14.1 14 1 abnormal dermal layer morphology 0.0384207049935024 0.414136052633158 1.26264520073365 0.371428571428571 14.1 14 1 ovary cysts 0.0384207049935024 0.414136052633158 1.26264520073365 0.371428571428571 14.1 14 1 holoprosencephaly 0.0384207049935024 0.414136052633158 1.26264520073365 0.371428571428571 14.1 14 1 decreased rib number 0.00155174861057633 0.062257655948526 1.26046258154482 0.370786516853933 14.1 14 1 axon degeneration 0.0122979991678738 0.213924985525078 1.25904792095948 0.37037037037037 14.1 14 1 thick interventricular septum 0.066469544704152 0.54931226728099 1.25904792095948 0.37037037037037 14.1 14 1 decreased double-positive T cell number 0.00087579247501596 0.0411044109736264 1.25778887303852 0.37 14.1 14 1 decreased bone marrow cell number 0.00412425434032718 0.114626622028646 1.25732319778008 0.36986301369863 14.1 14 1 abnormal forelimb morphology 0.0205309196240981 0.29606181197069 1.25631086026174 0.369565217391304 14.1 14 1 decreased birth body size 0.000454246483331844 0.025391868028943 1.25242135295443 0.368421052631579 14.1 14 1 absent vitelline blood vessels 0.0111797868680018 0.210101261145482 1.25242135295443 0.368421052631579 14.1 14 1 decreased neuron apoptosis 0.034681840836139 0.400817067946116 1.25242135295443 0.368421052631579 14.1 14 1 shiny skin 0.118755608862478 0.71861123143697 1.25242135295443 0.368421052631579 14.1 14 1 abnormal neurotransmitter level 0.118755608862478 0.71861123143697 1.25242135295443 0.368421052631579 14.1 14 1 increased liver adenoma incidence 0.118755608862478 0.71861123143697 1.25242135295443 0.368421052631579 14.1 14 1 absent amnion 0.118755608862478 0.71861123143697 1.25242135295443 0.368421052631579 14.1 14 1 Leydig cell hypoplasia 0.118755608862478 0.71861123143697 1.25242135295443 0.368421052631579 14.1 14 1 shortened RR interval 0.118755608862478 0.71861123143697 1.25242135295443 0.368421052631579 14.1 14 1 embryonic lethality between implantation and somite formation, incomplete penetrance 0.118755608862478 0.71861123143697 1.25242135295443 0.368421052631579 14.1 14 1 abnormal placenta morphology 0.0034312322742944 0.101008169021388 1.24789180014085 0.367088607594937 14.1 14 1 abnormal eating behavior 0.0101602605445754 0.199891422189983 1.24645744174988 0.366666666666667 14.1 14 1 intracranial hemorrhage 0.0101602605445754 0.199891422189983 1.24645744174988 0.366666666666667 14.1 14 1 abnormal incisor morphology 0.0101602605445754 0.199891422189983 1.24645744174988 0.366666666666667 14.1 14 1 abnormal spleen marginal zone morphology 0.0595940738602793 0.500811684890016 1.24645744174988 0.366666666666667 14.1 14 1 abnormal cellular respiration 0.0595940738602793 0.500811684890016 1.24645744174988 0.366666666666667 14.1 14 1 thin ventricular wall 0.00192270753370109 0.0709932723017373 1.24645744174988 0.366666666666667 14.1 14 1 oxidative stress 0.00192270753370109 0.0709932723017373 1.24645744174988 0.366666666666667 14.1 14 1 ataxia 5.23687181611506e-06 0.000766277567210953 1.24533551785992 0.366336633663366 14.1 14 1 decreased embryo size 3.52927532982229e-12 1.59619497871508e-09 1.24456096789404 0.366108786610879 14.1 14 1 abnormal placenta vasculature 0.016864768800885 0.259759209858833 1.24209919894656 0.365384615384615 14.1 14 1 abnormal vitelline vasculature morphology 0.000560075458658663 0.029024743821113 1.24153073249395 0.365217391304348 14.1 14 1 infertility 0.000903460437339558 0.0415904190413084 1.23904435586012 0.364485981308411 14.1 14 1 decreased circulating total protein level 0.0152823582634394 0.245708820982997 1.23615614057839 0.363636363636364 14.1 14 1 muscular atrophy 0.0282620184989847 0.355059449576891 1.23615614057839 0.363636363636364 14.1 14 1 embryonic lethality, incomplete penetrance 0.0282620184989847 0.355059449576891 1.23615614057839 0.363636363636364 14.1 14 1 enlarged pericardium 0.053461907666673 0.466619281827541 1.23615614057839 0.363636363636364 14.1 14 1 belly spot 0.053461907666673 0.466619281827541 1.23615614057839 0.363636363636364 14.1 14 1 single kidney 0.053461907666673 0.466619281827541 1.23615614057839 0.363636363636364 14.1 14 1 increased osteoblast cell number 0.053461907666673 0.466619281827541 1.23615614057839 0.363636363636364 14.1 14 1 abnormal germ layer development 0.105199883116036 0.706889308977192 1.23615614057839 0.363636363636364 14.1 14 1 abnormal vascular branching morphogenesis 0.105199883116036 0.706889308977192 1.23615614057839 0.363636363636364 14.1 14 1 abnormal limb posture 0.105199883116036 0.706889308977192 1.23615614057839 0.363636363636364 14.1 14 1 abnormal occipital bone morphology 0.105199883116036 0.706889308977192 1.23615614057839 0.363636363636364 14.1 14 1 failure of palatal shelf elevation 0.105199883116036 0.706889308977192 1.23615614057839 0.363636363636364 14.1 14 1 rough coat 0.105199883116036 0.706889308977192 1.23615614057839 0.363636363636364 14.1 14 1 increased adenoma incidence 0.105199883116036 0.706889308977192 1.23615614057839 0.363636363636364 14.1 14 1 abnormal extraembryonic tissue morphology 0.0013322509741451 0.0561690559014564 1.23312634611619 0.362745098039216 14.1 14 1 abnormal erythropoiesis 0.00121494902870199 0.0530208019104597 1.23026968276612 0.361904761904762 14.1 14 1 pale yolk sac 0.0038500963874469 0.109452740157419 1.22870941683997 0.36144578313253 14.1 14 1 abnormal axon morphology 0.0011078219350366 0.0492090547036349 1.22757172293549 0.361111111111111 14.1 14 1 abnormal forebrain development 0.00691923676520713 0.155761099126269 1.22757172293549 0.361111111111111 14.1 14 1 female infertility 5.09489202505327e-07 9.74887993255385e-05 1.22686173350638 0.360902255639098 14.1 14 1 abnormal axon extension 0.023044248477555 0.319015874168928 1.22379457917261 0.36 14.1 14 1 abnormal primitive streak morphology 0.093404794732636 0.646566047059155 1.22379457917261 0.36 14.1 14 1 abnormal cochlear outer hair cell morphology 0.093404794732636 0.646566047059155 1.22379457917261 0.36 14.1 14 1 abnormal vertebrae development 0.093404794732636 0.646566047059155 1.22379457917261 0.36 14.1 14 1 abnormal craniofacial morphology 0.00162987551701864 0.0623740822859055 1.22115424566846 0.359223300970874 14.1 14 1 absent gastric milk in neonates 0.00570743685429605 0.142290072197083 1.22030798492995 0.358974358974359 14.1 14 1 abnormal placenta development 0.0208152862237816 0.29843241776171 1.21866336500417 0.358490566037736 14.1 14 1 lethality throughout fetal growth and development, complete penetrance 2.94543103783738e-05 0.00299051416596755 1.21663788572716 0.357894736842105 14.1 14 1 decreased birth weight 0.00263624997890642 0.0868565804308573 1.21663788572716 0.357894736842105 14.1 14 1 myoclonus 0.0830982652875614 0.604452447357692 1.21408192378235 0.357142857142857 14.1 14 1 increased bone resorption 0.0830982652875614 0.604452447357692 1.21408192378235 0.357142857142857 14.1 14 1 abnormal brainstem morphology 0.0830982652875614 0.604452447357692 1.21408192378235 0.357142857142857 14.1 14 1 increased triglyceride level 0.0830982652875614 0.604452447357692 1.21408192378235 0.357142857142857 14.1 14 1 abnormal interparietal bone morphology 0.195161436355251 0.740555644741389 1.21408192378235 0.357142857142857 14.1 14 1 megacephaly 0.195161436355251 0.740555644741389 1.21408192378235 0.357142857142857 14.1 14 1 abnormal kidney blood vessel morphology 0.195161436355251 0.740555644741389 1.21408192378235 0.357142857142857 14.1 14 1 translucent skin 0.195161436355251 0.740555644741389 1.21408192378235 0.357142857142857 14.1 14 1 absent visceral yolk sac blood islands 0.195161436355251 0.740555644741389 1.21408192378235 0.357142857142857 14.1 14 1 abnormal fluid regulation 0.195161436355251 0.740555644741389 1.21408192378235 0.357142857142857 14.1 14 1 increased lactate dehydrogenase level 0.195161436355251 0.740555644741389 1.21408192378235 0.357142857142857 14.1 14 1 absent otoliths 0.195161436355251 0.740555644741389 1.21408192378235 0.357142857142857 14.1 14 1 abnormal sagittal suture morphology 0.195161436355251 0.740555644741389 1.21408192378235 0.357142857142857 14.1 14 1 abnormal viscerocranium morphology 0.195161436355251 0.740555644741389 1.21408192378235 0.357142857142857 14.1 14 1 pulmonary alveolar hemorrhage 0.195161436355251 0.740555644741389 1.21408192378235 0.357142857142857 14.1 14 1 decreased compact bone area 0.195161436355251 0.740555644741389 1.21408192378235 0.357142857142857 14.1 14 1 testis degeneration 0.195161436355251 0.740555644741389 1.21408192378235 0.357142857142857 14.1 14 1 abnormal vitelline vein topology 0.195161436355251 0.740555644741389 1.21408192378235 0.357142857142857 14.1 14 1 polydactyly 0.00239781982384303 0.0817065316686238 1.21408192378235 0.357142857142857 14.1 14 1 skin edema 0.0387476733984535 0.414136052633158 1.21408192378235 0.357142857142857 14.1 14 1 increased insulin sensitivity 0.000300487787669821 0.0191657274827866 1.21238390710573 0.356643356643357 14.1 14 1 abnormal thoracic vertebrae morphology 0.0169956777539531 0.260967582796039 1.20996639183733 0.355932203389831 14.1 14 1 abnormal ovarian follicle morphology 0.0348490115650448 0.400817067946116 1.2086860041211 0.355555555555556 14.1 14 1 abnormal metabolism 0.0348490115650448 0.400817067946116 1.2086860041211 0.355555555555556 14.1 14 1 decreased circulating glucose level 8.37099397217555e-07 0.000134340951650237 1.2062491371773 0.354838709677419 14.1 14 1 pericardial effusion 0.0153631339975785 0.245708820982997 1.2062491371773 0.354838709677419 14.1 14 1 decreased double-negative T cell number 0.0740588913452699 0.589488700066298 1.2062491371773 0.354838709677419 14.1 14 1 abnormal somite development 0.00695711780017934 0.15590838313465 1.20486104841185 0.354430379746835 14.1 14 1 abnormal embryonic tissue morphology 0.000331306766207848 0.0203487797763462 1.20251923879395 0.353741496598639 14.1 14 1 abnormal motor coordination/ balance 0.00291033544702059 0.0911064118269806 1.20181847000677 0.353535353535354 14.1 14 1 abnormal lung development 0.0057202039074204 0.142290072197083 1.19979860703197 0.352941176470588 14.1 14 1 distended urinary bladder 0.169725119721026 0.740555644741389 1.19979860703197 0.352941176470588 14.1 14 1 hyperlipidemia 0.169725119721026 0.740555644741389 1.19979860703197 0.352941176470588 14.1 14 1 abnormal heart rate 0.169725119721026 0.740555644741389 1.19979860703197 0.352941176470588 14.1 14 1 abnormal dorsal-ventral axis patterning 0.169725119721026 0.740555644741389 1.19979860703197 0.352941176470588 14.1 14 1 increased regulatory T cell number 0.169725119721026 0.740555644741389 1.19979860703197 0.352941176470588 14.1 14 1 increased circulating magnesium level 0.169725119721026 0.740555644741389 1.19979860703197 0.352941176470588 14.1 14 1 abnormal survival 0.169725119721026 0.740555644741389 1.19979860703197 0.352941176470588 14.1 14 1 abnormal cell cytoskeleton morphology 0.169725119721026 0.740555644741389 1.19979860703197 0.352941176470588 14.1 14 1 abnormal suckling behavior 0.00518776607618419 0.137282639516044 1.19752626118532 0.352272727272727 14.1 14 1 preweaning lethality, incomplete penetrance 5.64962570529945e-09 1.65334634610969e-06 1.19686511410524 0.352078239608802 14.1 14 1 increased cell proliferation 0.0254389563398459 0.340211848899821 1.1960955249115 0.351851851851852 14.1 14 1 abnormal apoptosis 0.0254389563398459 0.340211848899821 1.1960955249115 0.351851851851852 14.1 14 1 increased hepatocellular carcinoma incidence 0.022928947506997 0.318635513539972 1.19278224090898 0.350877192982456 14.1 14 1 abnormal myocardial fiber morphology 0.00387257561712782 0.109466270995516 1.19155256849567 0.350515463917526 14.1 14 1 absent mesoderm 0.0206762870205411 0.297296323488994 1.1898002853067 0.35 14.1 14 1 decreased myocardial infarction size 0.148526398621571 0.740555644741389 1.1898002853067 0.35 14.1 14 1 abnormal hyoid bone morphology 0.148526398621571 0.740555644741389 1.1898002853067 0.35 14.1 14 1 kidney atrophy 0.148526398621571 0.740555644741389 1.1898002853067 0.35 14.1 14 1 abnormal response to tactile stimuli 0.148526398621571 0.740555644741389 1.1898002853067 0.35 14.1 14 1 increased oxygen consumption 0.00690819551188724 0.155761099126269 1.18584746043858 0.348837209302326 14.1 14 1 abnormal male reproductive system morphology 0.0473742268104611 0.45813555528897 1.18584746043858 0.348837209302326 14.1 14 1 abnormal vasculogenesis 0.0473742268104611 0.45813555528897 1.18584746043858 0.348837209302326 14.1 14 1 decreased oxygen consumption 0.0473742268104611 0.45813555528897 1.18584746043858 0.348837209302326 14.1 14 1 anophthalmia 0.00625753780379954 0.15112257560147 1.18407090993605 0.348314606741573 14.1 14 1 embryonic lethality, complete penetrance 5.77204016170923e-07 9.902034415346e-05 1.18287354831208 0.347962382445141 14.1 14 1 thymus hypoplasia 0.000838965321026655 0.0397509759248344 1.18241022142281 0.347826086956522 14.1 14 1 abnormal allantois morphology 0.0424853272668831 0.439239942337833 1.18241022142281 0.347826086956522 14.1 14 1 abnormal pulmonary artery morphology 0.130593986537758 0.71861123143697 1.18241022142281 0.347826086956522 14.1 14 1 abnormal carpal bone morphology 0.130593986537758 0.71861123143697 1.18241022142281 0.347826086956522 14.1 14 1 abnormal circulating insulin level 0.130593986537758 0.71861123143697 1.18241022142281 0.347826086956522 14.1 14 1 abnormal corneal stroma morphology 0.130593986537758 0.71861123143697 1.18241022142281 0.347826086956522 14.1 14 1 decreased effector memory CD8-positive, alpha-beta T cell number 0.130593986537758 0.71861123143697 1.18241022142281 0.347826086956522 14.1 14 1 abnormal neuromuscular synapse morphology 0.0137291020943297 0.231533162438272 1.18035742589951 0.347222222222222 14.1 14 1 abnormal digit morphology 0.0137291020943297 0.231533162438272 1.18035742589951 0.347222222222222 14.1 14 1 hydrops fetalis 0.0137291020943297 0.231533162438272 1.18035742589951 0.347222222222222 14.1 14 1 abnormal bone structure 9.78261486339818e-05 0.00752523549641271 1.18011279223611 0.347150259067358 14.1 14 1 increased T cell derived lymphoma incidence 0.0381352912080885 0.414136052633158 1.17939386881714 0.346938775510204 14.1 14 1 lethality throughout fetal growth and development, incomplete penetrance 0.000186604777264984 0.0128938717624069 1.17745598865149 0.346368715083799 14.1 14 1 decreased bone mineral content 6.12679160798967e-05 0.00534750671048221 1.17672555689674 0.346153846153846 14.1 14 1 kinked neural tube 0.0342587537415261 0.400817067946116 1.17672555689674 0.346153846153846 14.1 14 1 decreased circulating glycerol level 0.115258927688297 0.71861123143697 1.17672555689674 0.346153846153846 14.1 14 1 decreased circulating calcium level 0.0307993831023937 0.384027395825585 1.17434833354947 0.345454545454545 14.1 14 1 postnatal lethality, incomplete penetrance 8.05467014814475e-11 3.08246030669385e-08 1.17304253480943 0.345070422535211 14.1 14 1 embryonic growth arrest 3.18428728609031e-05 0.00316836584965986 1.1727289150247 0.344978165938865 14.1 14 1 abnormal embryonic neuroepithelium morphology 0.027708418112389 0.351144382934486 1.17221702985882 0.344827586206897 14.1 14 1 abnormal circulating glucose level 0.10203622629384 0.69671278460678 1.17221702985882 0.344827586206897 14.1 14 1 respiratory failure 0.000683630211169646 0.0330200029181455 1.17066442452126 0.344370860927152 14.1 14 1 lethargy 0.00679295856660267 0.155761099126269 1.16969613302042 0.344086021505376 14.1 14 1 increased sacral vertebrae number 0.0224676330774946 0.3139788611251 1.16855385164051 0.34375 14.1 14 1 abnormal vertebral body morphology 0.0905606635835537 0.639062838763375 1.16855385164051 0.34375 14.1 14 1 abnormal lymphatic vessel morphology 0.0905606635835537 0.639062838763375 1.16855385164051 0.34375 14.1 14 1 abnormal lumbar vertebrae morphology 0.0905606635835537 0.639062838763375 1.16855385164051 0.34375 14.1 14 1 cleft palate 0.00159433545517034 0.062337895017657 1.16774291905783 0.343511450381679 14.1 14 1 embryonic lethality during organogenesis, incomplete penetrance 3.7801084693143e-05 0.00368745875192915 1.16763009365503 0.343478260869565 14.1 14 1 rib fusion 0.020248537760217 0.2928385911543 1.16696829688931 0.343283582089552 14.1 14 1 abnormal liver development 0.0805491411337551 0.604452447357692 1.16551864683106 0.342857142857143 14.1 14 1 increased circulating serum albumin level 0.0805491411337551 0.604452447357692 1.16551864683106 0.342857142857143 14.1 14 1 decreased grip strength 6.52146904514418e-05 0.00559384629303316 1.16418814609267 0.342465753424658 14.1 14 1 abnormal hepatocyte morphology 0.00375295801350996 0.108104601680034 1.16376861883281 0.342342342342342 14.1 14 1 increased bone marrow cell number 0.0717771910389263 0.577818002295563 1.16296268488625 0.342105263157895 14.1 14 1 decreased hair follicle number 0.0717771910389263 0.577818002295563 1.16296268488625 0.342105263157895 14.1 14 1 persistence of hyaloid vascular system 0.0717771910389263 0.577818002295563 1.16296268488625 0.342105263157895 14.1 14 1 increased grooming behavior 0.0717771910389263 0.577818002295563 1.16296268488625 0.342105263157895 14.1 14 1 impaired branching involved in ureteric bud morphogenesis 0.0717771910389263 0.577818002295563 1.16296268488625 0.342105263157895 14.1 14 1 abnormal heart development 0.000670614994953007 0.0327089176459922 1.16183029668286 0.341772151898734 14.1 14 1 abnormal behavior 8.46002646164359e-06 0.00109522603168566 1.16167550980614 0.341726618705036 14.1 14 1 abnormal developmental patterning 0.0121224058975111 0.213886124284756 1.16078076615288 0.341463414634146 14.1 14 1 decreased cell proliferation 0.000284036610240198 0.0183517160512336 1.15764352083896 0.340540540540541 14.1 14 1 reduced female fertility 5.29184615347014e-05 0.00478671538427526 1.15756431698559 0.34051724137931 14.1 14 1 increased cellular sensitivity to gamma-irradiation 0.051242857689116 0.45813555528897 1.15725255713722 0.340425531914894 14.1 14 1 neuron degeneration 0.051242857689116 0.45813555528897 1.15725255713722 0.340425531914894 14.1 14 1 increased respiratory quotient 0.051242857689116 0.45813555528897 1.15725255713722 0.340425531914894 14.1 14 1 hydroencephaly 0.00403687172908365 0.112828296922422 1.15284996588724 0.339130434782609 14.1 14 1 abnormal embryo development 0.00203307708876027 0.0730409472874272 1.14980699840564 0.338235294117647 14.1 14 1 decreased litter size 1.38495447036435e-05 0.0015659428386506 1.14927328016408 0.338078291814947 14.1 14 1 kidney cysts 0.0196275549446221 0.284685381485408 1.14845587384817 0.337837837837838 14.1 14 1 abnormal lens morphology 0.00321515554965678 0.0957808314942664 1.14199580955777 0.3359375 14.1 14 1 decreased body size 9.37364270497953e-13 4.66338724572732e-10 1.14166300201288 0.335839598997494 14.1 14 1 cyanosis 0.000493362976061581 0.0268250240141104 1.13314312886353 0.333333333333333 14.1 14 1 spleen hypoplasia 0.0083675552158365 0.175879751263921 1.13314312886353 0.333333333333333 14.1 14 1 abnormal tail morphology 0.0318660631036498 0.396334159851645 1.13314312886353 0.333333333333333 14.1 14 1 increased circulating aspartate transaminase level 0.0354491477178474 0.400817067946116 1.13314312886353 0.333333333333333 14.1 14 1 epidermal hyperplasia 0.0394650531648019 0.418632493592515 1.13314312886353 0.333333333333333 14.1 14 1 decreased tumor growth/size 0.0490393273846262 0.45813555528897 1.13314312886353 0.333333333333333 14.1 14 1 small lung 0.0547453176267182 0.470393704996413 1.13314312886353 0.333333333333333 14.1 14 1 curly tail 0.0611837966845999 0.509864972371666 1.13314312886353 0.333333333333333 14.1 14 1 abnormal phalanx morphology 0.0611837966845999 0.509864972371666 1.13314312886353 0.333333333333333 14.1 14 1 trabecula carnea hypoplasia 0.0684652719162113 0.562999550054796 1.13314312886353 0.333333333333333 14.1 14 1 abnormal cell migration 0.0684652719162113 0.562999550054796 1.13314312886353 0.333333333333333 14.1 14 1 lethality at weaning, complete penetrance 0.0684652719162113 0.562999550054796 1.13314312886353 0.333333333333333 14.1 14 1 abnormal iris morphology 0.0861113265389939 0.612881043678819 1.13314312886353 0.333333333333333 14.1 14 1 renal hypoplasia 0.0968279298633311 0.669054098708433 1.13314312886353 0.333333333333333 14.1 14 1 abnormal response to new environment 0.12325730251062 0.71861123143697 1.13314312886353 0.333333333333333 14.1 14 1 abnormal skeleton physiology 0.109110041541994 0.71861123143697 1.13314312886353 0.333333333333333 14.1 14 1 decreased brown adipose tissue amount 0.109110041541994 0.71861123143697 1.13314312886353 0.333333333333333 14.1 14 1 abnormal optic cup morphology 0.12325730251062 0.71861123143697 1.13314312886353 0.333333333333333 14.1 14 1 abnormal fetal cardiomyocyte proliferation 0.13965361918037 0.735992325659259 1.13314312886353 0.333333333333333 14.1 14 1 decreased circulating fructosamine level 0.13965361918037 0.735992325659259 1.13314312886353 0.333333333333333 14.1 14 1 abnormal foregut morphology 0.158803550033622 0.740555644741389 1.13314312886353 0.333333333333333 14.1 14 1 delayed kidney development 0.208389285888105 0.740555644741389 1.13314312886353 0.333333333333333 14.1 14 1 right pulmonary isomerism 0.208389285888105 0.740555644741389 1.13314312886353 0.333333333333333 14.1 14 1 absent spleen 0.208389285888105 0.740555644741389 1.13314312886353 0.333333333333333 14.1 14 1 blepharoptosis 0.208389285888105 0.740555644741389 1.13314312886353 0.333333333333333 14.1 14 1 abnormal nursing 0.158803550033622 0.740555644741389 1.13314312886353 0.333333333333333 14.1 14 1 trunk curl 0.181392082050759 0.740555644741389 1.13314312886353 0.333333333333333 14.1 14 1 abnormal hematopoietic system physiology 0.181392082050759 0.740555644741389 1.13314312886353 0.333333333333333 14.1 14 1 hemolytic anemia 0.158803550033622 0.740555644741389 1.13314312886353 0.333333333333333 14.1 14 1 blindness 0.158803550033622 0.740555644741389 1.13314312886353 0.333333333333333 14.1 14 1 abnormal primitive streak formation 0.158803550033622 0.740555644741389 1.13314312886353 0.333333333333333 14.1 14 1 abnormal white adipose tissue morphology 0.208389285888105 0.740555644741389 1.13314312886353 0.333333333333333 14.1 14 1 acidosis 0.208389285888105 0.740555644741389 1.13314312886353 0.333333333333333 14.1 14 1 increased circulating renin level 0.208389285888105 0.740555644741389 1.13314312886353 0.333333333333333 14.1 14 1 abnormal erythrocyte physiology 0.181392082050759 0.740555644741389 1.13314312886353 0.333333333333333 14.1 14 1 absent ureter 0.208389285888105 0.740555644741389 1.13314312886353 0.333333333333333 14.1 14 1 abnormal embryonic/fetal subventricular zone morphology 0.181392082050759 0.740555644741389 1.13314312886353 0.333333333333333 14.1 14 1 abnormal retinal ganglion layer morphology 0.158803550033622 0.740555644741389 1.13314312886353 0.333333333333333 14.1 14 1 complete atrioventricular septal defect 0.181392082050759 0.740555644741389 1.13314312886353 0.333333333333333 14.1 14 1 vascular ring 0.181392082050759 0.740555644741389 1.13314312886353 0.333333333333333 14.1 14 1 abnormal aerobic respiration 0.208389285888105 0.740555644741389 1.13314312886353 0.333333333333333 14.1 14 1 embryonic lethality at implantation, complete penetrance 0.181392082050759 0.740555644741389 1.13314312886353 0.333333333333333 14.1 14 1 increased muscle cell glucose uptake 0.181392082050759 0.740555644741389 1.13314312886353 0.333333333333333 14.1 14 1 interdigital webbing 0.241249077462529 0.776335161950894 1.13314312886353 0.333333333333333 14.1 14 1 abnormal epidermis stratum spinosum morphology 0.241249077462529 0.776335161950894 1.13314312886353 0.333333333333333 14.1 14 1 abnormal cricoid cartilage morphology 0.241249077462529 0.776335161950894 1.13314312886353 0.333333333333333 14.1 14 1 increased alcohol consumption 0.241249077462529 0.776335161950894 1.13314312886353 0.333333333333333 14.1 14 1 abnormal pericyte morphology 0.241249077462529 0.776335161950894 1.13314312886353 0.333333333333333 14.1 14 1 abnormal zygomatic bone morphology 0.241249077462529 0.776335161950894 1.13314312886353 0.333333333333333 14.1 14 1 abnormal energy homeostasis 0.241249077462529 0.776335161950894 1.13314312886353 0.333333333333333 14.1 14 1 bicuspid aortic valve 0.241249077462529 0.776335161950894 1.13314312886353 0.333333333333333 14.1 14 1 abnormal coronary vessel morphology 0.241249077462529 0.776335161950894 1.13314312886353 0.333333333333333 14.1 14 1 herniated liver 0.241249077462529 0.776335161950894 1.13314312886353 0.333333333333333 14.1 14 1 perinatal lethality, complete penetrance 0.000252788094599785 0.0169486790611119 1.13314312886353 0.333333333333333 14.1 14 1 increased monocyte cell number 0.0120098062225383 0.213886124284756 1.12181169757489 0.33 14.1 14 1 limb grasping 0.000986384737159897 0.0446114915215499 1.12069100656832 0.32967032967033 14.1 14 1 abnormal brain morphology 0.00194072060965553 0.0709932723017373 1.11906681670373 0.329192546583851 14.1 14 1 decreased compact bone thickness 0.0375457421604393 0.414136052633158 1.11623054485064 0.328358208955224 14.1 14 1 maternal effect 0.0375457421604393 0.414136052633158 1.11623054485064 0.328358208955224 14.1 14 1 decreased lymphocyte cell number 0.00570028581922521 0.142290072197083 1.11543776747504 0.328125 14.1 14 1 abnormal embryo size 0.00937584646085298 0.193547037936695 1.11308749826417 0.327433628318584 14.1 14 1 abnormal head morphology 0.0579128137921989 0.489161712421374 1.11254052652056 0.327272727272727 14.1 14 1 abnormal rostral-caudal axis patterning 0.0579128137921989 0.489161712421374 1.11254052652056 0.327272727272727 14.1 14 1 failure to gastrulate 0.0810362128755636 0.604452447357692 1.10850958258389 0.326086956521739 14.1 14 1 prenatal lethality, incomplete penetrance 5.06907470313903e-05 0.00475823521662579 1.10705101734364 0.325657894736842 14.1 14 1 increased circulating insulin level 0.0028821790000222 0.0911064118269806 1.10481455064194 0.325 14.1 14 1 impaired ovarian folliculogenesis 0.102112454807561 0.69671278460678 1.10481455064194 0.325 14.1 14 1 decreased erythrocyte cell number 0.00317663980214248 0.095203512142523 1.10427324023006 0.32484076433121 14.1 14 1 impaired skeletal muscle contractility 0.114943731479714 0.71861123143697 1.10251763889424 0.324324324324324 14.1 14 1 increased insulin secretion 0.114943731479714 0.71861123143697 1.10251763889424 0.324324324324324 14.1 14 1 decreased width of hypertrophic chondrocyte zone 0.114943731479714 0.71861123143697 1.10251763889424 0.324324324324324 14.1 14 1 abnormal calcium ion homeostasis 0.114943731479714 0.71861123143697 1.10251763889424 0.324324324324324 14.1 14 1 skin inflammation 0.114943731479714 0.71861123143697 1.10251763889424 0.324324324324324 14.1 14 1 reduced fertility 0.00571260582841836 0.142290072197083 1.10053469350055 0.323741007194245 14.1 14 1 ventricular septal defect 0.00630333500264043 0.151493196319498 1.09981538977931 0.323529411764706 14.1 14 1 decreased mean corpuscular hemoglobin 0.0439395977656577 0.44703374004938 1.09981538977931 0.323529411764706 14.1 14 1 enlarged liver sinusoidal spaces 0.129677619464585 0.71861123143697 1.09981538977931 0.323529411764706 14.1 14 1 abnormal retinal photoreceptor morphology 0.129677619464585 0.71861123143697 1.09981538977931 0.323529411764706 14.1 14 1 abnormal endoderm development 0.129677619464585 0.71861123143697 1.09981538977931 0.323529411764706 14.1 14 1 hemorrhage 0.000444005293231544 0.0251014356116697 1.09938992928036 0.323404255319149 14.1 14 1 decreased circulating serum albumin level 0.0180568293434484 0.266659312447697 1.09880545829191 0.323232323232323 14.1 14 1 perinatal lethality, incomplete penetrance 0.000590285741154805 0.0300258804299925 1.09804577531466 0.323008849557522 14.1 14 1 abnormal postnatal growth/weight/body size 0.146685117351263 0.740555644741389 1.09659012470664 0.32258064516129 14.1 14 1 decreased thymus weight 0.146685117351263 0.740555644741389 1.09659012470664 0.32258064516129 14.1 14 1 abnormal podocyte morphology 0.146685117351263 0.740555644741389 1.09659012470664 0.32258064516129 14.1 14 1 decreased body weight 3.61332430942778e-15 2.99604807323386e-12 1.09561577160714 0.322294022617124 14.1 14 1 abnormal retinal pigmentation 0.0272108032242966 0.351144382934486 1.09406922786823 0.32183908045977 14.1 14 1 abnormal testis morphology 0.01262642985666 0.216608581161667 1.0937294548161 0.321739130434783 14.1 14 1 abnormal nervous system physiology 0.01262642985666 0.216608581161667 1.0937294548161 0.321739130434783 14.1 14 1 shortened head 0.166442997340121 0.740555644741389 1.09267373140412 0.321428571428571 14.1 14 1 increased exploration in new environment 0.0334932473047458 0.397682351649428 1.09117486483155 0.320987654320988 14.1 14 1 increased urine protein level 0.0371882485769758 0.414136052633158 1.08956070083032 0.320512820512821 14.1 14 1 abnormal neurocranium morphology 0.0413146425791752 0.433629423694929 1.08781740370899 0.32 14.1 14 1 abnormal interventricular septum morphology 0.0848055895991294 0.604452447357692 1.08781740370899 0.32 14.1 14 1 increased B cell derived lymphoma incidence 0.0848055895991294 0.604452447357692 1.08781740370899 0.32 14.1 14 1 testicular atrophy 0.0848055895991294 0.604452447357692 1.08781740370899 0.32 14.1 14 1 abnormal keratinocyte physiology 0.189579434881145 0.740555644741389 1.08781740370899 0.32 14.1 14 1 decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 0.189579434881145 0.740555644741389 1.08781740370899 0.32 14.1 14 1 edema 0.00330256306899283 0.0977991146919007 1.08702683873536 0.319767441860465 14.1 14 1 decreased bone mineral density 0.000329969652811482 0.0203487797763462 1.0862838265421 0.319548872180451 14.1 14 1 perimembraneous ventricular septal defect 0.0510893693478523 0.45813555528897 1.08387603630424 0.318840579710145 14.1 14 1 abnormal glucose homeostasis 0.0028391898306626 0.0905446756894001 1.08333463968271 0.318681318681319 14.1 14 1 abnormal astrocyte morphology 0.106582917092886 0.713660851328541 1.0816366230061 0.318181818181818 14.1 14 1 abnormal chorion morphology 0.21694844155363 0.740555644741389 1.0816366230061 0.318181818181818 14.1 14 1 increased myocardial infarction size 0.21694844155363 0.740555644741389 1.0816366230061 0.318181818181818 14.1 14 1 aphakia 0.21694844155363 0.740555644741389 1.0816366230061 0.318181818181818 14.1 14 1 abnormal lysosome physiology 0.21694844155363 0.740555644741389 1.0816366230061 0.318181818181818 14.1 14 1 parakeratosis 0.21694844155363 0.740555644741389 1.0816366230061 0.318181818181818 14.1 14 1 prolonged PR interval 0.21694844155363 0.740555644741389 1.0816366230061 0.318181818181818 14.1 14 1 decreased body length 0.000357431108481741 0.0214243345144176 1.07938086362548 0.317518248175182 14.1 14 1 decreased total body fat amount 9.04160096362521e-05 0.00725515561194119 1.07886082328923 0.317365269461078 14.1 14 1 increased tumor growth/size 0.119778000486124 0.71861123143697 1.07786785428482 0.317073170731707 14.1 14 1 palatal shelves fail to meet at midline 0.119778000486124 0.71861123143697 1.07786785428482 0.317073170731707 14.1 14 1 abnormal pulmonary alveolus morphology 0.0240903329262077 0.325677734532291 1.07704693436533 0.316831683168317 14.1 14 1 abnormal myocardium layer morphology 0.0430017088562797 0.442926504264992 1.07576879322487 0.316455696202532 14.1 14 1 abnormal heart morphology 0.00116527937860718 0.051303229279387 1.07427855074075 0.316017316017316 14.1 14 1 premature death 8.85205917932453e-10 3.14564245836711e-07 1.07391962038634 0.315911730545877 14.1 14 1 decreased total retina thickness 0.134866750144693 0.71861123143697 1.07350401681808 0.315789473684211 14.1 14 1 thin dermal layer 0.249758675284549 0.79804072545962 1.07350401681808 0.315789473684211 14.1 14 1 increased malignant tumor incidence 0.249758675284549 0.79804072545962 1.07350401681808 0.315789473684211 14.1 14 1 abnormal nasal septum morphology 0.249758675284549 0.79804072545962 1.07350401681808 0.315789473684211 14.1 14 1 increased susceptibility to ischemic brain injury 0.249758675284549 0.79804072545962 1.07350401681808 0.315789473684211 14.1 14 1 maternal imprinting 0.249758675284549 0.79804072545962 1.07350401681808 0.315789473684211 14.1 14 1 abnormal sternebra morphology 0.249758675284549 0.79804072545962 1.07350401681808 0.315789473684211 14.1 14 1 abnormal blastocyst morphology 0.249758675284549 0.79804072545962 1.07350401681808 0.315789473684211 14.1 14 1 abnormal behavioral response to xenobiotic 0.249758675284549 0.79804072545962 1.07350401681808 0.315789473684211 14.1 14 1 decreased susceptibility to weight gain 0.249758675284549 0.79804072545962 1.07350401681808 0.315789473684211 14.1 14 1 seminiferous tubule degeneration 0.0530825127072575 0.466619281827541 1.07105309440525 0.315068493150685 14.1 14 1 impaired coordination 0.000100973504621854 0.00761126038626855 1.07091850618027 0.315028901734104 14.1 14 1 abnormal maxilla morphology 0.0881015816898619 0.625257302292529 1.07019073281555 0.314814814814815 14.1 14 1 abnormal cell adhesion 0.0881015816898619 0.625257302292529 1.07019073281555 0.314814814814815 14.1 14 1 increased circulating HDL cholesterol level 0.0249927088920246 0.336050612804925 1.06839209292847 0.314285714285714 14.1 14 1 abnormal midbrain development 0.152194838699548 0.740555644741389 1.06839209292847 0.314285714285714 14.1 14 1 decreased triglyceride level 0.152194838699548 0.740555644741389 1.06839209292847 0.314285714285714 14.1 14 1 decreased circulating thyroxine level 0.152194838699548 0.740555644741389 1.06839209292847 0.314285714285714 14.1 14 1 decreased bone volume 0.152194838699548 0.740555644741389 1.06839209292847 0.314285714285714 14.1 14 1 impaired adaptive thermogenesis 0.152194838699548 0.740555644741389 1.06839209292847 0.314285714285714 14.1 14 1 microphthalmia 0.00850701064046693 0.177825117379508 1.06648765069509 0.313725490196078 14.1 14 1 kinked tail 0.027645667920945 0.351144382934486 1.06648765069509 0.313725490196078 14.1 14 1 impaired balance 0.027645667920945 0.351144382934486 1.06648765069509 0.313725490196078 14.1 14 1 abnormal cervical vertebrae morphology 0.0985474282150887 0.67804224380429 1.06648765069509 0.313725490196078 14.1 14 1 abnormal thrombosis 0.0985474282150887 0.67804224380429 1.06648765069509 0.313725490196078 14.1 14 1 postnatal lethality, complete penetrance 5.55320700802556e-05 0.00493342944016556 1.06562423776544 0.313471502590674 14.1 14 1 postnatal lethality 0.00659266031079114 0.153983497869417 1.06488149459464 0.313253012048193 14.1 14 1 abnormal coat/hair pigmentation 0.0233928104296939 0.319015874168928 1.06232168330956 0.3125 14.1 14 1 abnormal tooth morphology 0.0731668962672586 0.587105336983245 1.06232168330956 0.3125 14.1 14 1 bradykinesia 0.172196232700222 0.740555644741389 1.06232168330956 0.3125 14.1 14 1 pancreatic islet hyperplasia 0.172196232700222 0.740555644741389 1.06232168330956 0.3125 14.1 14 1 abnormal intestinal absorption 0.289813596131507 0.865902367135599 1.06232168330956 0.3125 14.1 14 1 abnormal olfaction 0.289813596131507 0.865902367135599 1.06232168330956 0.3125 14.1 14 1 decreased circulating growth hormone level 0.289813596131507 0.865902367135599 1.06232168330956 0.3125 14.1 14 1 abnormal intestinal lipid absorption 0.289813596131507 0.865902367135599 1.06232168330956 0.3125 14.1 14 1 dilated respiratory conducting tubes 0.289813596131507 0.865902367135599 1.06232168330956 0.3125 14.1 14 1 decreased adipocyte glucose uptake 0.289813596131507 0.865902367135599 1.06232168330956 0.3125 14.1 14 1 postnatal growth retardation 6.83416770582418e-07 0.000113333281121584 1.06093302751438 0.312091503267974 14.1 14 1 decreased circulating cholesterol level 0.0052860030006658 0.139142142477843 1.05883866139707 0.311475409836066 14.1 14 1 abnormal maternal nurturing 0.0815543693713676 0.604452447357692 1.05883866139707 0.311475409836066 14.1 14 1 abnormal long bone morphology 0.0815543693713676 0.604452447357692 1.05883866139707 0.311475409836066 14.1 14 1 irregular heartbeat 0.123797337495255 0.71861123143697 1.05760025360596 0.311111111111111 14.1 14 1 abnormal ectoderm development 0.123797337495255 0.71861123143697 1.05760025360596 0.311111111111111 14.1 14 1 pale liver 0.0609981637297903 0.509864972371666 1.05657940394032 0.310810810810811 14.1 14 1 abnormal gait 0.000428651145613055 0.0245119476945396 1.05613340165921 0.310679611650485 14.1 14 1 abnormal motor capabilities/coordination/movement 0.0167990497802193 0.259550536200593 1.05588337007738 0.310606060606061 14.1 14 1 enlarged heart 0.00212837106500873 0.0745679299184397 1.05499532687294 0.310344827586207 14.1 14 1 dermatitis 0.0909852576584385 0.641149655595937 1.05499532687294 0.310344827586207 14.1 14 1 abnormal parietal bone morphology 0.195426044310948 0.740555644741389 1.05499532687294 0.310344827586207 14.1 14 1 decreased granulocyte number 0.195426044310948 0.740555644741389 1.05499532687294 0.310344827586207 14.1 14 1 absent long term depression 0.195426044310948 0.740555644741389 1.05499532687294 0.310344827586207 14.1 14 1 abnormal eye morphology 0.0157057088797623 0.245710382631502 1.05162204045608 0.309352517985612 14.1 14 1 abnormal contextual conditioning behavior 0.101607083117764 0.69531669671372 1.05073271949164 0.309090909090909 14.1 14 1 decreased heart weight 0.0565817383261412 0.482837303898032 1.04920660079956 0.308641975308642 14.1 14 1 pallor 0.00795956828735644 0.175216160307957 1.04896678214795 0.308571428571429 14.1 14 1 double outlet right ventricle 0.0325399226654975 0.396385302078131 1.04842214726626 0.308411214953271 14.1 14 1 decreased neutrophil cell number 0.0274384766749482 0.351144382934486 1.0459782727971 0.307692307692308 14.1 14 1 hypoactivity 0.000180860262091073 0.0126729549845505 1.0459782727971 0.307692307692308 14.1 14 1 increased rib number 0.0627850193085119 0.522333563645228 1.0459782727971 0.307692307692308 14.1 14 1 abnormal brain wave pattern 0.11359253659026 0.71861123143697 1.0459782727971 0.307692307692308 14.1 14 1 abnormal Schwann cell morphology 0.222610771411299 0.740555644741389 1.0459782727971 0.307692307692308 14.1 14 1 small seminal vesicle 0.222610771411299 0.740555644741389 1.0459782727971 0.307692307692308 14.1 14 1 decreased trabecular bone volume 0.156535827302781 0.740555644741389 1.0459782727971 0.307692307692308 14.1 14 1 neonatal lethality, complete penetrance 4.72813038502204e-05 0.00452354782028551 1.04368446079535 0.307017543859649 14.1 14 1 abnormal limb morphology 0.0697043365464087 0.566632474376444 1.04249167855445 0.306666666666667 14.1 14 1 improved glucose tolerance 0.006509415394311 0.152822427517728 1.0406416489563 0.306122448979592 14.1 14 1 increased total body fat amount 0.0215847562246044 0.305780590058764 1.04012391679264 0.305970149253731 14.1 14 1 abnormal enzyme/coenzyme activity 0.0140636288061048 0.235577620573641 1.03931599080476 0.305732484076433 14.1 14 1 abnormal retinal blood vessel morphology 0.176556278587484 0.740555644741389 1.03871453479157 0.305555555555556 14.1 14 1 decreased circulating HDL cholesterol level 0.0261963795952625 0.348467883653559 1.03576364122682 0.3046875 14.1 14 1 abnormal myelin sheath morphology 0.14250532951637 0.740555644741389 1.03460894374496 0.304347826086957 14.1 14 1 atrial septal defect 0.14250532951637 0.740555644741389 1.03460894374496 0.304347826086957 14.1 14 1 abnormal cranial nerve morphology 0.254728515623074 0.810796138979395 1.03460894374496 0.304347826086957 14.1 14 1 abnormal postnatal growth 0.254728515623074 0.810796138979395 1.03460894374496 0.304347826086957 14.1 14 1 abnormal Wolffian duct morphology 0.254728515623074 0.810796138979395 1.03460894374496 0.304347826086957 14.1 14 1 decreased epididymis weight 0.254728515623074 0.810796138979395 1.03460894374496 0.304347826086957 14.1 14 1 abnormal lens development 0.254728515623074 0.810796138979395 1.03460894374496 0.304347826086957 14.1 14 1 abnormal neuron differentiation 0.0378067169430378 0.414136052633158 1.031969635215 0.303571428571429 14.1 14 1 anemia 0.00637753622835879 0.152221024331992 1.03110654379999 0.303317535545024 14.1 14 1 abnormal tooth development 0.199625011464669 0.740555644741389 1.03013011714866 0.303030303030303 14.1 14 1 abnormal ovarian folliculogenesis 0.199625011464669 0.740555644741389 1.03013011714866 0.303030303030303 14.1 14 1 abnormal epidermis stratum basale morphology 0.199625011464669 0.740555644741389 1.03013011714866 0.303030303030303 14.1 14 1 increased cardiomyocyte apoptosis 0.199625011464669 0.740555644741389 1.03013011714866 0.303030303030303 14.1 14 1 abnormal vertebrae morphology 0.0417163630482293 0.436006105388531 1.02918504364669 0.302752293577982 14.1 14 1 increased bone mineral content 0.0417163630482293 0.436006105388531 1.02918504364669 0.302752293577982 14.1 14 1 increased circulating alkaline phosphatase level 0.0162001998795567 0.252652020065186 1.02822246878357 0.302469135802469 14.1 14 1 abnormal urine homeostasis 0.0549897423898059 0.470912993339364 1.02691096053257 0.302083333333333 14.1 14 1 enlarged kidney 0.129933436592746 0.71861123143697 1.02624283368772 0.30188679245283 14.1 14 1 gliosis 0.106526607965477 0.713660851328541 1.02522473563843 0.301587301587302 14.1 14 1 short tail 0.0729607190691614 0.586396732421774 1.02392451403331 0.301204819277108 14.1 14 1 increased circulating cholesterol level 0.0140199481325923 0.235577620573641 1.02369180391648 0.301136363636364 14.1 14 1 hypoglycemia 0.0607891767176404 0.509134939680574 1.02348411639286 0.301075268817204 14.1 14 1 kyphosis 0.02359084652037 0.319794172857877 1.01982881597718 0.3 14.1 14 1 abnormal lipid homeostasis 0.0331634953706523 0.396385302078131 1.01982881597718 0.3 14.1 14 1 increased metastatic potential 0.226355505082517 0.740555644741389 1.01982881597718 0.3 14.1 14 1 enhanced paired-pulse facilitation 0.226355505082517 0.740555644741389 1.01982881597718 0.3 14.1 14 1 abnormal cell proliferation 0.293143936711539 0.865902367135599 1.01982881597718 0.3 14.1 14 1 increased urine glucose level 0.293143936711539 0.865902367135599 1.01982881597718 0.3 14.1 14 1 abnormal dopamine level 0.293143936711539 0.865902367135599 1.01982881597718 0.3 14.1 14 1 abnormal trachea morphology 0.293143936711539 0.865902367135599 1.01982881597718 0.3 14.1 14 1 absent placental labyrinth 0.293143936711539 0.865902367135599 1.01982881597718 0.3 14.1 14 1 abnormal incus morphology 0.293143936711539 0.865902367135599 1.01982881597718 0.3 14.1 14 1 increased skin tumor incidence 0.293143936711539 0.865902367135599 1.01982881597718 0.3 14.1 14 1 abnormal heart electrocardiography waveform feature 0.293143936711539 0.865902367135599 1.01982881597718 0.3 14.1 14 1 decreased muscle cell glucose uptake 0.293143936711539 0.865902367135599 1.01982881597718 0.3 14.1 14 1 enlarged liver 0.0561053747058557 0.479594912648852 1.01982881597718 0.3 14.1 14 1 increased body length 0.145290392259863 0.740555644741389 1.01982881597718 0.3 14.1 14 1 decreased leukocyte cell number 0.0307260707726293 0.384027395825585 1.0173474806585 0.299270072992701 14.1 14 1 decreased white adipose tissue amount 0.108489638684439 0.71861123143697 1.01475504077331 0.298507462686567 14.1 14 1 pulmonary hypoplasia 0.162658321624255 0.740555644741389 1.01259598749507 0.297872340425532 14.1 14 1 hepatic necrosis 0.162658321624255 0.740555644741389 1.01259598749507 0.297872340425532 14.1 14 1 abnormal T-helper 1 physiology 0.162658321624255 0.740555644741389 1.01259598749507 0.297872340425532 14.1 14 1 abnormal intestine morphology 0.099326158246962 0.68064412848297 1.01064116898639 0.297297297297297 14.1 14 1 malocclusion 0.202623125440771 0.740555644741389 1.01064116898639 0.297297297297297 14.1 14 1 increased circulating phosphate level 0.202623125440771 0.740555644741389 1.01064116898639 0.297297297297297 14.1 14 1 increased trabecular bone volume 0.202623125440771 0.740555644741389 1.01064116898639 0.297297297297297 14.1 14 1 decreased circulating LDL cholesterol level 0.120611819571392 0.71861123143697 1.00920559914408 0.296875 14.1 14 1 diluted coat color 0.147546849183434 0.740555644741389 1.00723833676758 0.296296296296296 14.1 14 1 abnormal long bone epiphyseal plate proliferative zone 0.147546849183434 0.740555644741389 1.00723833676758 0.296296296296296 14.1 14 1 abnormal neuronal precursor proliferation 0.147546849183434 0.740555644741389 1.00723833676758 0.296296296296296 14.1 14 1 decreased platelet aggregation 0.147546849183434 0.740555644741389 1.00723833676758 0.296296296296296 14.1 14 1 abnormal atrioventricular cushion morphology 0.257540098666427 0.812821751340375 1.00723833676758 0.296296296296296 14.1 14 1 abnormal trigeminal ganglion morphology 0.257540098666427 0.812821751340375 1.00723833676758 0.296296296296296 14.1 14 1 thin epidermis 0.257540098666427 0.812821751340375 1.00723833676758 0.296296296296296 14.1 14 1 neonatal lethality, incomplete penetrance 0.00587215408869179 0.145343117369361 1.00675408756721 0.296153846153846 14.1 14 1 atelectasis 0.110176884030129 0.71861123143697 1.00546502983665 0.295774647887324 14.1 14 1 decreased liver weight 0.110176884030129 0.71861123143697 1.00546502983665 0.295774647887324 14.1 14 1 abnormal amino acid level 0.182346045597987 0.740555644741389 1.00437686421995 0.295454545454545 14.1 14 1 decreased blood urea nitrogen level 0.182346045597987 0.740555644741389 1.00437686421995 0.295454545454545 14.1 14 1 increased osteoclast cell number 0.134173971589737 0.71861123143697 1.00311031079722 0.295081967213115 14.1 14 1 distended abdomen 0.164766627278519 0.740555644741389 0.999832172526643 0.294117647058824 14.1 14 1 abnormal gastrulation 0.164766627278519 0.740555644741389 0.999832172526643 0.294117647058824 14.1 14 1 abnormal gluconeogenesis 0.164766627278519 0.740555644741389 0.999832172526643 0.294117647058824 14.1 14 1 abnormal response to novel object 0.164766627278519 0.740555644741389 0.999832172526643 0.294117647058824 14.1 14 1 abnormal trophoblast layer morphology 0.164766627278519 0.740555644741389 0.999832172526643 0.294117647058824 14.1 14 1 overexpanded pulmonary alveoli 0.228769758131371 0.744362031853217 0.999832172526643 0.294117647058824 14.1 14 1 impaired synaptic plasticity 0.228769758131371 0.744362031853217 0.999832172526643 0.294117647058824 14.1 14 1 abnormal vagus nerve morphology 0.339850461302541 0.915149486403383 0.999832172526643 0.294117647058824 14.1 14 1 abnormal touch/ nociception 0.339850461302541 0.915149486403383 0.999832172526643 0.294117647058824 14.1 14 1 abnormal glutamate-mediated receptor currents 0.339850461302541 0.915149486403383 0.999832172526643 0.294117647058824 14.1 14 1 absence seizures 0.339850461302541 0.915149486403383 0.999832172526643 0.294117647058824 14.1 14 1 abnormal melanosome morphology 0.339850461302541 0.915149486403383 0.999832172526643 0.294117647058824 14.1 14 1 abnormal tarsal bone morphology 0.339850461302541 0.915149486403383 0.999832172526643 0.294117647058824 14.1 14 1 pancytopenia 0.339850461302541 0.915149486403383 0.999832172526643 0.294117647058824 14.1 14 1 enhanced behavioral response to cocaine 0.339850461302541 0.915149486403383 0.999832172526643 0.294117647058824 14.1 14 1 common atrium 0.339850461302541 0.915149486403383 0.999832172526643 0.294117647058824 14.1 14 1 abnormal ductus venosus valve morphology 0.339850461302541 0.915149486403383 0.999832172526643 0.294117647058824 14.1 14 1 abnormal cardiovascular system physiology 0.0461766943562912 0.45813555528897 0.996825158473931 0.293233082706767 14.1 14 1 decreased anxiety-related response 0.0549950651517931 0.470912993339364 0.994954942416757 0.292682926829268 14.1 14 1 liver fibrosis 0.204721700551605 0.740555644741389 0.994954942416757 0.292682926829268 14.1 14 1 abnormal cholesterol homeostasis 0.204721700551605 0.740555644741389 0.994954942416757 0.292682926829268 14.1 14 1 extramedullary hematopoiesis 0.0713998633920172 0.577818002295563 0.994172745134982 0.292452830188679 14.1 14 1 increased startle reflex 0.093443414640308 0.646566047059155 0.993091730914103 0.292134831460674 14.1 14 1 overriding aortic valve 0.184187287718785 0.740555644741389 0.991500237755587 0.291666666666667 14.1 14 1 oligodactyly 0.184187287718785 0.740555644741389 0.991500237755587 0.291666666666667 14.1 14 1 vertebral transformation 0.184187287718785 0.740555644741389 0.991500237755587 0.291666666666667 14.1 14 1 abnormal body weight 0.29422703086579 0.865902367135599 0.991500237755587 0.291666666666667 14.1 14 1 decreased metastatic potential 0.29422703086579 0.865902367135599 0.991500237755587 0.291666666666667 14.1 14 1 abnormal startle reflex 0.29422703086579 0.865902367135599 0.991500237755587 0.291666666666667 14.1 14 1 decreased fatty acid level 0.29422703086579 0.865902367135599 0.991500237755587 0.291666666666667 14.1 14 1 abnormal inner cell mass apoptosis 0.29422703086579 0.865902367135599 0.991500237755587 0.291666666666667 14.1 14 1 liver inflammation 0.0604175217450068 0.506875498619576 0.991500237755587 0.291666666666667 14.1 14 1 hunched posture 0.112853728883557 0.71861123143697 0.989707289766879 0.291139240506329 14.1 14 1 abnormal eyelid morphology 0.258947936427121 0.812821751340375 0.986931112235976 0.290322580645161 14.1 14 1 abnormal object recognition memory 0.258947936427121 0.812821751340375 0.986931112235976 0.290322580645161 14.1 14 1 abnormal intestine physiology 0.258947936427121 0.812821751340375 0.986931112235976 0.290322580645161 14.1 14 1 increased body weight 0.0167351647630128 0.259368986591866 0.986441563073161 0.290178571428571 14.1 14 1 abnormal epidermal layer morphology 0.137049099382899 0.726886214744052 0.985341851185677 0.289855072463768 14.1 14 1 abnormal compact bone morphology 0.23022757463547 0.74801097680096 0.984045348749906 0.289473684210526 14.1 14 1 hyporesponsive to tactile stimuli 0.23022757463547 0.74801097680096 0.984045348749906 0.289473684210526 14.1 14 1 abnormal rib morphology 0.0567552639103624 0.483488763619953 0.982057378348391 0.288888888888889 14.1 14 1 absent corpus luteum 0.185512880260246 0.740555644741389 0.980604630747284 0.288461538461538 14.1 14 1 eyelids open at birth 0.185512880260246 0.740555644741389 0.980604630747284 0.288461538461538 14.1 14 1 hyperactivity 0.00349540521368581 0.102292005518158 0.980428421469522 0.288409703504043 14.1 14 1 abnormal fertility/fecundity 0.138090736007483 0.730852565571517 0.97791804271784 0.287671232876712 14.1 14 1 decreased percent body fat/body weight 0.138090736007483 0.730852565571517 0.97791804271784 0.287671232876712 14.1 14 1 abnormal posture 0.125775562296278 0.71861123143697 0.977335948644793 0.2875 14.1 14 1 decreased B cell number 0.0280393557138152 0.354050240295001 0.973622979654585 0.286407766990291 14.1 14 1 obese 0.138915046007342 0.733654303488882 0.971265539025881 0.285714285714286 14.1 14 1 polyuria 0.138915046007342 0.733654303488882 0.971265539025881 0.285714285714286 14.1 14 1 dehydration 0.152811177446409 0.740555644741389 0.971265539025881 0.285714285714286 14.1 14 1 abnormal respiratory system physiology 0.207004222221642 0.740555644741389 0.971265539025881 0.285714285714286 14.1 14 1 enhanced long term potentiation 0.186420871797044 0.740555644741389 0.971265539025881 0.285714285714286 14.1 14 1 thick pulmonary interalveolar septum 0.259399725904099 0.812821751340375 0.971265539025881 0.285714285714286 14.1 14 1 abnormal embryonic epiblast morphology 0.259399725904099 0.812821751340375 0.971265539025881 0.285714285714286 14.1 14 1 decreased glycogen level 0.259399725904099 0.812821751340375 0.971265539025881 0.285714285714286 14.1 14 1 lymphoid hyperplasia 0.29397893919695 0.865902367135599 0.971265539025881 0.285714285714286 14.1 14 1 reddish skin 0.29397893919695 0.865902367135599 0.971265539025881 0.285714285714286 14.1 14 1 abnormal retinal inner nuclear layer morphology 0.29397893919695 0.865902367135599 0.971265539025881 0.285714285714286 14.1 14 1 increased vasoconstriction 0.337844678575851 0.915149486403383 0.971265539025881 0.285714285714286 14.1 14 1 liver degeneration 0.337844678575851 0.915149486403383 0.971265539025881 0.285714285714286 14.1 14 1 decreased cochlear outer hair cell number 0.337844678575851 0.915149486403383 0.971265539025881 0.285714285714286 14.1 14 1 increased bone ossification 0.337844678575851 0.915149486403383 0.971265539025881 0.285714285714286 14.1 14 1 abnormal liver morphology 0.0422179641142923 0.439239942337833 0.968552506793966 0.284916201117318 14.1 14 1 increased granulocyte number 0.15345028568618 0.740555644741389 0.964702934032463 0.283783783783784 14.1 14 1 abnormal kidney development 0.186987085110142 0.740555644741389 0.963171659533999 0.283333333333333 14.1 14 1 increased erythrocyte cell number 0.186987085110142 0.740555644741389 0.963171659533999 0.283333333333333 14.1 14 1 increased circulating bilirubin level 0.207452134339523 0.740555644741389 0.962102656582241 0.283018867924528 14.1 14 1 atrioventricular septal defect 0.207452134339523 0.740555644741389 0.962102656582241 0.283018867924528 14.1 14 1 thrombocytopenia 0.0696714069212255 0.566632474376444 0.961217964484234 0.282758620689655 14.1 14 1 abnormal locomotor behavior 0.127647110468386 0.71861123143697 0.960708304906035 0.282608695652174 14.1 14 1 cardiac fibrosis 0.140019516477458 0.737139782513602 0.959838885625577 0.282352941176471 14.1 14 1 abnormal spatial learning 0.0592805632654306 0.499865766517826 0.959348170448877 0.282208588957055 14.1 14 1 abnormal circulating hormone level 0.25917790394474 0.812821751340375 0.958813416730678 0.282051282051282 14.1 14 1 retinal degeneration 0.128000317167346 0.71861123143697 0.956089514978602 0.28125 14.1 14 1 kidney cortex cysts 0.292894255276777 0.865902367135599 0.956089514978602 0.28125 14.1 14 1 failure of primitive streak formation 0.292894255276777 0.865902367135599 0.956089514978602 0.28125 14.1 14 1 neonatal lethality 0.292894255276777 0.865902367135599 0.956089514978602 0.28125 14.1 14 1 abnormal depression-related behavior 0.292894255276777 0.865902367135599 0.956089514978602 0.28125 14.1 14 1 abnormal embryonic hematopoiesis 0.292894255276777 0.865902367135599 0.956089514978602 0.28125 14.1 14 1 abnormal spongiotrophoblast layer morphology 0.292894255276777 0.865902367135599 0.956089514978602 0.28125 14.1 14 1 abnormal auditory brainstem response waveform shape 0.292894255276777 0.865902367135599 0.956089514978602 0.28125 14.1 14 1 abnormal retina morphology 0.0400569921823883 0.421318258155141 0.955077780042117 0.280952380952381 14.1 14 1 seizures 0.107258111179388 0.717216536448194 0.954225792727182 0.280701754385965 14.1 14 1 increased macrophage cell number 0.207559787238377 0.740555644741389 0.954225792727182 0.280701754385965 14.1 14 1 sparse hair 0.154164919805923 0.740555644741389 0.953498486482725 0.280487804878049 14.1 14 1 insulin resistance 0.0903769303438394 0.639062838763375 0.952870358362512 0.28030303030303 14.1 14 1 delayed bone ossification 0.169716837822515 0.740555644741389 0.951840228245364 0.28 14.1 14 1 abnormal hindlimb morphology 0.231004044984555 0.749181958147434 0.951840228245364 0.28 14.1 14 1 abnormal feces composition 0.334923318193152 0.915149486403383 0.951840228245364 0.28 14.1 14 1 abnormal preimplantation embryo development 0.334923318193152 0.915149486403383 0.951840228245364 0.28 14.1 14 1 increased liver glycogen level 0.334923318193152 0.915149486403383 0.951840228245364 0.28 14.1 14 1 abnormal definitive hematopoiesis 0.140539775356689 0.738752553878307 0.950378108079088 0.279569892473118 14.1 14 1 increased circulating creatinine level 0.154289222577935 0.740555644741389 0.948677968350861 0.27906976744186 14.1 14 1 abnormal homeostasis 0.258469252262273 0.812821751340375 0.948677968350861 0.27906976744186 14.1 14 1 abnormal axon guidance 0.258469252262273 0.812821751340375 0.948677968350861 0.27906976744186 14.1 14 1 decreased B cell proliferation 0.169732315416729 0.740555644741389 0.946676538037884 0.278481012658228 14.1 14 1 decreased IgM level 0.140622847944273 0.738752553878307 0.946232922040678 0.278350515463918 14.1 14 1 impaired glucose tolerance 0.0347268784907003 0.400817067946116 0.945808982559477 0.278225806451613 14.1 14 1 short snout 0.128440739592855 0.71861123143697 0.944285940719607 0.277777777777778 14.1 14 1 abnormal mandible morphology 0.230492628630326 0.74801097680096 0.944285940719607 0.277777777777778 14.1 14 1 polyphagia 0.230492628630326 0.74801097680096 0.944285940719607 0.277777777777778 14.1 14 1 reduced long term depression 0.291262590256644 0.865902367135599 0.944285940719607 0.277777777777778 14.1 14 1 abnormal limb bone morphology 0.291262590256644 0.865902367135599 0.944285940719607 0.277777777777778 14.1 14 1 narrow eye opening 0.291262590256644 0.865902367135599 0.944285940719607 0.277777777777778 14.1 14 1 lowered ear position 0.390412451846554 0.915149486403383 0.944285940719607 0.277777777777778 14.1 14 1 abnormal megakaryocyte differentiation 0.390412451846554 0.915149486403383 0.944285940719607 0.277777777777778 14.1 14 1 abnormal mitral valve morphology 0.390412451846554 0.915149486403383 0.944285940719607 0.277777777777778 14.1 14 1 cortical renal glomerulopathies 0.390412451846554 0.915149486403383 0.944285940719607 0.277777777777778 14.1 14 1 abnormal mammary gland morphology 0.390412451846554 0.915149486403383 0.944285940719607 0.277777777777778 14.1 14 1 abnormal retinal rod cell morphology 0.390412451846554 0.915149486403383 0.944285940719607 0.277777777777778 14.1 14 1 abnormal thymus medulla morphology 0.390412451846554 0.915149486403383 0.944285940719607 0.277777777777778 14.1 14 1 decreased activity of thyroid 0.390412451846554 0.915149486403383 0.944285940719607 0.277777777777778 14.1 14 1 abnormal pregnancy 0.390412451846554 0.915149486403383 0.944285940719607 0.277777777777778 14.1 14 1 decreased tumor latency 0.390412451846554 0.915149486403383 0.944285940719607 0.277777777777778 14.1 14 1 atrioventricular block 0.390412451846554 0.915149486403383 0.944285940719607 0.277777777777778 14.1 14 1 abnormal lipid level 0.169601082649846 0.740555644741389 0.942010552910644 0.27710843373494 14.1 14 1 decreased retinal photoreceptor cell number 0.331522899153521 0.915149486403383 0.937773623887058 0.275862068965517 14.1 14 1 abnormal CD8-positive, alpha-beta T cell physiology 0.331522899153521 0.915149486403383 0.937773623887058 0.275862068965517 14.1 14 1 abnormal blood vessel morphology 0.0988101762327859 0.67804224380429 0.937773623887058 0.275862068965517 14.1 14 1 increased blood urea nitrogen level 0.0988101762327859 0.67804224380429 0.937773623887058 0.275862068965517 14.1 14 1 abnormal food intake 0.206423144213915 0.740555644741389 0.936074758626393 0.27536231884058 14.1 14 1 decreased circulating phosphate level 0.28926395620626 0.865902367135599 0.934843081312411 0.275 14.1 14 1 perinatal lethality 0.28926395620626 0.865902367135599 0.934843081312411 0.275 14.1 14 1 abnormal B cell differentiation 0.168976306945846 0.740555644741389 0.933909172140271 0.274725274725275 14.1 14 1 abnormal dendritic spine morphology 0.256066851684137 0.812821751340375 0.9331766943582 0.274509803921569 14.1 14 1 hydronephrosis 0.185832854687518 0.740555644741389 0.93079614156647 0.273809523809524 14.1 14 1 abnormal nervous system electrophysiology 0.185832854687518 0.740555644741389 0.93079614156647 0.273809523809524 14.1 14 1 alopecia 0.168514370488929 0.740555644741389 0.930370147909002 0.273684210526316 14.1 14 1 impaired righting response 0.168514370488929 0.740555644741389 0.930370147909002 0.273684210526316 14.1 14 1 small kidney 0.185158618754529 0.740555644741389 0.927117105433796 0.272727272727273 14.1 14 1 increased T cell number 0.185158618754529 0.740555644741389 0.927117105433796 0.272727272727273 14.1 14 1 abnormal locomotor coordination 0.327870221706318 0.914836989898448 0.927117105433796 0.272727272727273 14.1 14 1 abnormal T cell subpopulation ratio 0.327870221706318 0.914836989898448 0.927117105433796 0.272727272727273 14.1 14 1 increased coping response 0.383180767459183 0.915149486403383 0.927117105433796 0.272727272727273 14.1 14 1 abnormal tracheal cartilage morphology 0.383180767459183 0.915149486403383 0.927117105433796 0.272727272727273 14.1 14 1 abnormal channel response 0.383180767459183 0.915149486403383 0.927117105433796 0.272727272727273 14.1 14 1 abnormal basement membrane morphology 0.383180767459183 0.915149486403383 0.927117105433796 0.272727272727273 14.1 14 1 cleft upper lip 0.383180767459183 0.915149486403383 0.927117105433796 0.272727272727273 14.1 14 1 abnormal mesenteric lymph node morphology 0.383180767459183 0.915149486403383 0.927117105433796 0.272727272727273 14.1 14 1 pulmonary vascular congestion 0.383180767459183 0.915149486403383 0.927117105433796 0.272727272727273 14.1 14 1 no abnormal phenotype detected 4.28097644815966e-06 0.000645389631199828 0.924801539176228 0.272046109510086 14.1 14 1 respiratory distress 0.0976197347768898 0.673589709452187 0.923544399825188 0.271676300578035 14.1 14 1 domed cranium 0.226396229872397 0.740555644741389 0.922702262074587 0.271428571428571 14.1 14 1 abnormal action potential 0.226396229872397 0.740555644741389 0.922702262074587 0.271428571428571 14.1 14 1 abnormal breathing pattern 0.32409202166993 0.906328166277629 0.918764699078536 0.27027027027027 14.1 14 1 decreased circulating chloride level 0.32409202166993 0.906328166277629 0.918764699078536 0.27027027027027 14.1 14 1 abnormal spleen morphology 0.105287432754191 0.706889308977192 0.918236673389411 0.270114942528736 14.1 14 1 abnormal hair follicle morphology 0.25103197704189 0.801594406792941 0.917306342413332 0.26984126984127 14.1 14 1 increased circulating glucose level 0.136836719928641 0.72653434540554 0.9161582744003 0.269503546099291 14.1 14 1 cachexia 0.181710315043179 0.740555644741389 0.915230988697465 0.269230769230769 14.1 14 1 abnormal skin condition 0.282060420103465 0.850236442518489 0.915230988697465 0.269230769230769 14.1 14 1 abnormal hair growth 0.282060420103465 0.850236442518489 0.915230988697465 0.269230769230769 14.1 14 1 thick skin 0.376301624902255 0.915149486403383 0.915230988697465 0.269230769230769 14.1 14 1 abnormal erythrocyte osmotic lysis 0.376301624902255 0.915149486403383 0.915230988697465 0.269230769230769 14.1 14 1 abnormal Mullerian duct morphology 0.376301624902255 0.915149486403383 0.915230988697465 0.269230769230769 14.1 14 1 pulmonary edema 0.376301624902255 0.915149486403383 0.915230988697465 0.269230769230769 14.1 14 1 Leydig cell hyperplasia 0.320262783279634 0.8971325150992 0.912042030548693 0.268292682926829 14.1 14 1 thick ventricular wall 0.320262783279634 0.8971325150992 0.912042030548693 0.268292682926829 14.1 14 1 lethality at weaning, incomplete penetrance 0.320262783279634 0.8971325150992 0.912042030548693 0.268292682926829 14.1 14 1 abnormal eye development 0.279447481486117 0.850236442518489 0.910561442836764 0.267857142857143 14.1 14 1 decreased hematocrit 0.14677000683069 0.740555644741389 0.90806675395228 0.267123287671233 14.1 14 1 abnormal long bone epiphyseal plate morphology 0.276785288478133 0.844271496124287 0.906514503090823 0.266666666666667 14.1 14 1 abnormal hair cycle 0.369765587906613 0.915149486403383 0.906514503090823 0.266666666666667 14.1 14 1 disorganized myocardium 0.369765587906613 0.915149486403383 0.906514503090823 0.266666666666667 14.1 14 1 abnormal brain vasculature morphology 0.369765587906613 0.915149486403383 0.906514503090823 0.266666666666667 14.1 14 1 abnormal fat pad morphology 0.369765587906613 0.915149486403383 0.906514503090823 0.266666666666667 14.1 14 1 albuminuria 0.316427817123802 0.896220890166147 0.906514503090823 0.266666666666667 14.1 14 1 small placenta 0.316427817123802 0.896220890166147 0.906514503090823 0.266666666666667 14.1 14 1 increased anxiety-related response 0.159761696293465 0.740555644741389 0.904884081322674 0.266187050359712 14.1 14 1 abnormal long bone hypertrophic chondrocyte zone 0.31261528952402 0.896220890166147 0.901889429095461 0.26530612244898 14.1 14 1 increased circulating LDL cholesterol level 0.31261528952402 0.896220890166147 0.901889429095461 0.26530612244898 14.1 14 1 absent kidney 0.31261528952402 0.896220890166147 0.901889429095461 0.26530612244898 14.1 14 1 abnormal epidermis stratum corneum morphology 0.31261528952402 0.896220890166147 0.901889429095461 0.26530612244898 14.1 14 1 decreased urine osmolality 0.31261528952402 0.896220890166147 0.901889429095461 0.26530612244898 14.1 14 1 abnormal inhibitory postsynaptic currents 0.271390222441184 0.828322918187048 0.899848955273978 0.264705882352941 14.1 14 1 lung hemorrhage 0.3635463885933 0.915149486403383 0.899848955273978 0.264705882352941 14.1 14 1 abnormal spleen red pulp morphology 0.3635463885933 0.915149486403383 0.899848955273978 0.264705882352941 14.1 14 1 abnormal bone mineralization 0.191200850432271 0.740555644741389 0.899022647693378 0.264462809917355 14.1 14 1 increased sensitivity to xenobiotic induced morbidity/mortality 0.210582258248998 0.740555644741389 0.896213201919336 0.263636363636364 14.1 14 1 abnormal axial skeleton morphology 0.26598468566475 0.812821751340375 0.894586680681733 0.263157894736842 14.1 14 1 abnormal reproductive system physiology 0.357615038467951 0.915149486403383 0.894586680681733 0.263157894736842 14.1 14 1 decreased threshold for auditory brainstem response 0.357615038467951 0.915149486403383 0.894586680681733 0.263157894736842 14.1 14 1 abnormal triglyceride level 0.440645943475842 0.967010837579317 0.894586680681733 0.263157894736842 14.1 14 1 abnormal nail morphology 0.440645943475842 0.967010837579317 0.894586680681733 0.263157894736842 14.1 14 1 short vibrissae 0.440645943475842 0.967010837579317 0.894586680681733 0.263157894736842 14.1 14 1 stereotypic behavior 0.440645943475842 0.967010837579317 0.894586680681733 0.263157894736842 14.1 14 1 unresponsive to tactile stimuli 0.440645943475842 0.967010837579317 0.894586680681733 0.263157894736842 14.1 14 1 abnormal neural crest cell migration 0.440645943475842 0.967010837579317 0.894586680681733 0.263157894736842 14.1 14 1 abnormal metatarsal bone morphology 0.440645943475842 0.967010837579317 0.894586680681733 0.263157894736842 14.1 14 1 abnormal optic vesicle formation 0.440645943475842 0.967010837579317 0.894586680681733 0.263157894736842 14.1 14 1 osteoarthritis 0.440645943475842 0.967010837579317 0.894586680681733 0.263157894736842 14.1 14 1 oliguria 0.440645943475842 0.967010837579317 0.894586680681733 0.263157894736842 14.1 14 1 abnormal cochlear inner hair cell morphology 0.440645943475842 0.967010837579317 0.894586680681733 0.263157894736842 14.1 14 1 abnormal CNS synaptic transmission 0.232643146855773 0.754006290298025 0.892779434862174 0.262626262626263 14.1 14 1 abnormal social investigation 0.263298539593239 0.812821751340375 0.892350213980029 0.2625 14.1 14 1 increased food intake 0.26063061226255 0.812821751340375 0.890326744107058 0.261904761904762 14.1 14 1 abnormal cranium morphology 0.200318797551658 0.740555644741389 0.887910660676645 0.261194029850746 14.1 14 1 decreased T cell number 0.176911918009049 0.740555644741389 0.886807666067109 0.260869565217391 14.1 14 1 abnormal skeleton morphology 0.224299694626113 0.740555644741389 0.886807666067109 0.260869565217391 14.1 14 1 abnormal sleep pattern 0.346509530157183 0.915149486403383 0.886807666067109 0.260869565217391 14.1 14 1 abnormal blood vessel physiology 0.428516856342515 0.9462367333795 0.886807666067109 0.260869565217391 14.1 14 1 abnormal innervation pattern to muscle 0.428516856342515 0.9462367333795 0.886807666067109 0.260869565217391 14.1 14 1 blistering 0.428516856342515 0.9462367333795 0.886807666067109 0.260869565217391 14.1 14 1 failure of embryo implantation 0.428516856342515 0.9462367333795 0.886807666067109 0.260869565217391 14.1 14 1 increased susceptibility to fungal infection 0.428516856342515 0.9462367333795 0.886807666067109 0.260869565217391 14.1 14 1 abnormal sternum morphology 0.294319779462572 0.865902367135599 0.886807666067109 0.260869565217391 14.1 14 1 decreased spleen weight 0.294319779462572 0.865902367135599 0.886807666067109 0.260869565217391 14.1 14 1 enlarged spleen 0.102231222665919 0.69671278460678 0.885268069424632 0.260416666666667 14.1 14 1 abnormal circulating protein level 0.341289510578426 0.915149486403383 0.883851640513552 0.26 14.1 14 1 decreased respiratory quotient 0.341289510578426 0.915149486403383 0.883851640513552 0.26 14.1 14 1 abnormal skeleton development 0.284096039459674 0.855037989299381 0.881333544671633 0.259259259259259 14.1 14 1 abnormal trigeminal nerve morphology 0.417868159084794 0.925598437865918 0.881333544671633 0.259259259259259 14.1 14 1 increased brain weight 0.417868159084794 0.925598437865918 0.881333544671633 0.259259259259259 14.1 14 1 abnormal skin appearance 0.417868159084794 0.925598437865918 0.881333544671633 0.259259259259259 14.1 14 1 decreased bone ossification 0.417868159084794 0.925598437865918 0.881333544671633 0.259259259259259 14.1 14 1 increased heart weight 0.21220395226119 0.740555644741389 0.880427754800439 0.258992805755396 14.1 14 1 thrombocytosis 0.331421098699557 0.915149486403383 0.879162772394117 0.258620689655172 14.1 14 1 prenatal lethality 0.326742130758988 0.912713138981452 0.877272099765312 0.258064516129032 14.1 14 1 autoimmune response 0.408310857986435 0.915149486403383 0.877272099765312 0.258064516129032 14.1 14 1 abnormal capillary morphology 0.408310857986435 0.915149486403383 0.877272099765312 0.258064516129032 14.1 14 1 abnormal T cell differentiation 0.268297585294832 0.819386425317242 0.875100634171834 0.257425742574257 14.1 14 1 increased red blood cell distribution width 0.399597156447254 0.915149486403383 0.874138985123293 0.257142857142857 14.1 14 1 decreased startle reflex 0.25667080453302 0.812821751340375 0.871648560664253 0.256410256410256 14.1 14 1 abnormal cornea morphology 0.309450639396247 0.896220890166147 0.871648560664253 0.256410256410256 14.1 14 1 abnormal heart ventricle morphology 0.309450639396247 0.896220890166147 0.871648560664253 0.256410256410256 14.1 14 1 increased vascular permeability 0.391558877958714 0.915149486403383 0.871648560664253 0.256410256410256 14.1 14 1 increased hepatocyte apoptosis 0.391558877958714 0.915149486403383 0.871648560664253 0.256410256410256 14.1 14 1 failure of heart looping 0.391558877958714 0.915149486403383 0.871648560664253 0.256410256410256 14.1 14 1 abnormal excitatory postsynaptic potential 0.3054372462446 0.896220890166147 0.870585574614662 0.25609756097561 14.1 14 1 increased leukocyte cell number 0.238178355129278 0.771443565604271 0.867440602095529 0.255172413793103 14.1 14 1 cardiac hypertrophy 0.290408512222101 0.865902367135599 0.867201374130251 0.255102040816327 14.1 14 1 abnormal cued conditioning behavior 0.370444630726472 0.915149486403383 0.866521216189757 0.254901960784314 14.1 14 1 cochlear inner hair cell degeneration 0.370444630726472 0.915149486403383 0.866521216189757 0.254901960784314 14.1 14 1 increased circulating free fatty acid level 0.341828727931355 0.915149486403383 0.861827168431416 0.253521126760563 14.1 14 1 abnormal CD4-positive, alpha-beta T cell physiology 0.341828727931355 0.915149486403383 0.861827168431416 0.253521126760563 14.1 14 1 decreased food intake 0.331937590316125 0.915149486403383 0.860615034579895 0.253164556962025 14.1 14 1 short limbs 0.322713892493773 0.903489935372269 0.85962582189647 0.252873563218391 14.1 14 1 abnormal kidney morphology 0.247648076952765 0.795897404935403 0.854713674342776 0.251428571428571 14.1 14 1 abnormal intestinal epithelium morphology 0.407882238621746 0.915149486403383 0.849857346647646 0.25 14.1 14 1 abnormal hair shaft morphology 0.407882238621746 0.915149486403383 0.849857346647646 0.25 14.1 14 1 increased stereotypic behavior 0.473280131501424 1 0.849857346647646 0.25 14.1 14 1 abnormal vasodilation 0.473280131501424 1 0.849857346647646 0.25 14.1 14 1 prolonged QT interval 0.473280131501424 1 0.849857346647646 0.25 14.1 14 1 decreased cardiac muscle contractility 0.32531449549294 0.909235738807515 0.849857346647646 0.25 14.1 14 1 short mandible 0.392417860891007 0.915149486403383 0.849857346647646 0.25 14.1 14 1 abnormal snout morphology 0.399906034267474 0.915149486403383 0.849857346647646 0.25 14.1 14 1 hyperglycemia 0.344290303968848 0.915149486403383 0.849857346647646 0.25 14.1 14 1 osteoporosis 0.416429849156035 0.924058206757928 0.849857346647646 0.25 14.1 14 1 abnormal circadian rhythm 0.416429849156035 0.924058206757928 0.849857346647646 0.25 14.1 14 1 renal interstitial fibrosis 0.416429849156035 0.924058206757928 0.849857346647646 0.25 14.1 14 1 abnormal photoreceptor outer segment morphology 0.416429849156035 0.924058206757928 0.849857346647646 0.25 14.1 14 1 increased susceptibility to weight loss 0.425657185209531 0.942012676342267 0.849857346647646 0.25 14.1 14 1 short radius 0.435708678510789 0.960838065421621 0.849857346647646 0.25 14.1 14 1 abnormal ovulation 0.459164565714077 0.99728980044388 0.849857346647646 0.25 14.1 14 1 abnormal respiration 0.459164565714077 0.99728980044388 0.849857346647646 0.25 14.1 14 1 absent corpus callosum 0.459164565714077 0.99728980044388 0.849857346647646 0.25 14.1 14 1 abnormal hormone level 0.459164565714077 0.99728980044388 0.849857346647646 0.25 14.1 14 1 corneal vascularization 0.459164565714077 0.99728980044388 0.849857346647646 0.25 14.1 14 1 abnormal pericardium morphology 0.489813279063943 1 0.849857346647646 0.25 14.1 14 1 abnormal circulating enzyme level 0.489813279063943 1 0.849857346647646 0.25 14.1 14 1 brain inflammation 0.489813279063943 1 0.849857346647646 0.25 14.1 14 1 anencephaly 0.489813279063943 1 0.849857346647646 0.25 14.1 14 1 abnormal fibula morphology 0.489813279063943 1 0.849857346647646 0.25 14.1 14 1 abnormal thymocyte activation 0.489813279063943 1 0.849857346647646 0.25 14.1 14 1 abnormal heart right ventricle morphology 0.489813279063943 1 0.849857346647646 0.25 14.1 14 1 dilated vasculature 0.489813279063943 1 0.849857346647646 0.25 14.1 14 1 abnormal osteoclast physiology 0.378656253870324 0.915149486403383 0.849857346647646 0.25 14.1 14 1 abnormal diaphragm morphology 0.446783058889654 0.980046612864211 0.849857346647646 0.25 14.1 14 1 increased circulating triglyceride level 0.302308446827948 0.888879741707472 0.843996261498352 0.248275862068966 14.1 14 1 decreased hemoglobin content 0.306093121661168 0.896220890166147 0.843829989579223 0.24822695035461 14.1 14 1 abnormal renal glomerulus morphology 0.340213151074516 0.915149486403383 0.842060490256384 0.247706422018349 14.1 14 1 abnormal muscle physiology 0.366189588980931 0.915149486403383 0.840308387696549 0.247191011235955 14.1 14 1 increased or absent threshold for auditory brainstem response 0.246759917708715 0.793555650032873 0.835153932345784 0.245674740484429 14.1 14 1 cleft secondary palate 0.382194556370192 0.915149486403383 0.831775275442377 0.24468085106383 14.1 14 1 abnormal cartilage development 0.448783447754699 0.983380674072614 0.830971627833254 0.244444444444444 14.1 14 1 increased circulating corticosterone level 0.448783447754699 0.983380674072614 0.830971627833254 0.244444444444444 14.1 14 1 abnormal mammary gland development 0.459655379380466 0.99728980044388 0.82912911868063 0.24390243902439 14.1 14 1 arrested B cell differentiation 0.459655379380466 0.99728980044388 0.82912911868063 0.24390243902439 14.1 14 1 increased bone trabecula number 0.459655379380466 0.99728980044388 0.82912911868063 0.24390243902439 14.1 14 1 abnormal angiogenesis 0.415719329858216 0.924058206757928 0.826888229170683 0.243243243243243 14.1 14 1 increased white adipose tissue amount 0.471585461066781 1 0.826888229170683 0.243243243243243 14.1 14 1 abnormal branching of the mammary ductal tree 0.471585461066781 1 0.826888229170683 0.243243243243243 14.1 14 1 abnormal vocalization 0.471585461066781 1 0.826888229170683 0.243243243243243 14.1 14 1 abnormal neuron morphology 0.397519345718666 0.915149486403383 0.82410409371893 0.242424242424242 14.1 14 1 impaired swimming 0.431543213439067 0.952074273551823 0.82410409371893 0.242424242424242 14.1 14 1 abnormal skin morphology 0.431543213439067 0.952074273551823 0.82410409371893 0.242424242424242 14.1 14 1 increased inflammatory response 0.403959542597398 0.915149486403383 0.823019746227194 0.242105263157895 14.1 14 1 increased thermal nociceptive threshold 0.410662734248333 0.915149486403383 0.821840071483438 0.241758241758242 14.1 14 1 cochlear ganglion degeneration 0.449291310988352 0.983380674072614 0.820551920901176 0.241379310344828 14.1 14 1 aphagia 0.499777823256072 1 0.820551920901176 0.241379310344828 14.1 14 1 abnormal embryonic erythropoiesis 0.499777823256072 1 0.820551920901176 0.241379310344828 14.1 14 1 abnormal chondrocyte morphology 0.459064221118256 0.99728980044388 0.818381148623659 0.240740740740741 14.1 14 1 abnormal osteoblast physiology 0.459064221118256 0.99728980044388 0.818381148623659 0.240740740740741 14.1 14 1 ruffled hair 0.516971756756669 1 0.81586305278174 0.24 14.1 14 1 mandible hypoplasia 0.516971756756669 1 0.81586305278174 0.24 14.1 14 1 kidney inflammation 0.469565980236162 1 0.81586305278174 0.24 14.1 14 1 abnormal egg cylinder morphology 0.516971756756669 1 0.81586305278174 0.24 14.1 14 1 increased pre-B cell number 0.516971756756669 1 0.81586305278174 0.24 14.1 14 1 decreased placenta weight 0.516971756756669 1 0.81586305278174 0.24 14.1 14 1 corneal opacity 0.449105624896078 0.983380674072614 0.813947881296337 0.23943661971831 14.1 14 1 abnormal skeletal muscle fiber morphology 0.449105624896078 0.983380674072614 0.813947881296337 0.23943661971831 14.1 14 1 abnormal inner ear morphology 0.480926678999632 1 0.812907027228183 0.239130434782609 14.1 14 1 increased bone mineral density 0.419666501289114 0.929168154834599 0.812253039273857 0.238938053097345 14.1 14 1 small ears 0.537303466716472 1 0.809387949188235 0.238095238095238 14.1 14 1 abnormal cartilage morphology 0.493315114268832 1 0.809387949188235 0.238095238095238 14.1 14 1 skin lesions 0.467529041377109 1 0.809387949188235 0.238095238095238 14.1 14 1 abnormal eye pigmentation 0.537303466716472 1 0.809387949188235 0.238095238095238 14.1 14 1 abnormal pancreas morphology 0.493315114268832 1 0.809387949188235 0.238095238095238 14.1 14 1 abnormal muscle morphology 0.493315114268832 1 0.809387949188235 0.238095238095238 14.1 14 1 abnormal tumor vascularization 0.537303466716472 1 0.809387949188235 0.238095238095238 14.1 14 1 increased circulating calcium level 0.488434611975878 1 0.803501491375957 0.236363636363636 14.1 14 1 abnormal learning/memory/conditioning 0.488434611975878 1 0.803501491375957 0.236363636363636 14.1 14 1 abnormal heart left ventricle morphology 0.474727824572702 1 0.802643049611666 0.236111111111111 14.1 14 1 abnormal trabecular bone morphology 0.452869112404854 0.990775652688719 0.799865738021314 0.235294117647059 14.1 14 1 short maxilla 0.52215479084833 1 0.799865738021314 0.235294117647059 14.1 14 1 thin skin 0.52215479084833 1 0.799865738021314 0.235294117647059 14.1 14 1 circling 0.472113637410636 1 0.799865738021314 0.235294117647059 14.1 14 1 increased kidney weight 0.500064857008375 1 0.799865738021314 0.235294117647059 14.1 14 1 decreased susceptibility to injury 0.484434261329428 1 0.799865738021314 0.235294117647059 14.1 14 1 increased susceptibility to weight gain 0.52215479084833 1 0.799865738021314 0.235294117647059 14.1 14 1 abnormal skin physiology 0.52215479084833 1 0.799865738021314 0.235294117647059 14.1 14 1 abnormal tibia morphology 0.512663510298193 1 0.795611133031839 0.234042553191489 14.1 14 1 increased T cell proliferation 0.475207061065416 1 0.794259202474436 0.233644859813084 14.1 14 1 arrested T cell differentiation 0.539346764449386 1 0.79320019020447 0.233333333333333 14.1 14 1 abnormal estrous cycle 0.539346764449386 1 0.79320019020447 0.233333333333333 14.1 14 1 abnormal pain threshold 0.539346764449386 1 0.79320019020447 0.233333333333333 14.1 14 1 abnormal intestinal mucosa morphology 0.526417800242001 1 0.790564973625717 0.232558139534884 14.1 14 1 hyperkeratosis 0.510594989694765 1 0.788273480948541 0.231884057971014 14.1 14 1 cataract 0.492443307058169 1 0.786644816731705 0.231404958677686 14.1 14 1 abnormal eye electrophysiology 0.492443307058169 1 0.786644816731705 0.231404958677686 14.1 14 1 increased B cell number 0.500310142696177 1 0.784483704597827 0.230769230769231 14.1 14 1 abnormal nasal bone morphology 0.559172796312993 1 0.784483704597827 0.230769230769231 14.1 14 1 abnormal xiphoid process morphology 0.559172796312993 1 0.784483704597827 0.230769230769231 14.1 14 1 small spleen 0.509328814022005 1 0.784483704597827 0.230769230769231 14.1 14 1 increased susceptibility to otitis media 0.559172796312993 1 0.784483704597827 0.230769230769231 14.1 14 1 abnormal ocular fundus morphology 0.559172796312993 1 0.784483704597827 0.230769230769231 14.1 14 1 decreased kidney weight 0.530112503830645 1 0.784483704597827 0.230769230769231 14.1 14 1 decreased B-1 B cell number 0.541574606495971 1 0.784483704597827 0.230769230769231 14.1 14 1 decreased bone resorption 0.559172796312993 1 0.784483704597827 0.230769230769231 14.1 14 1 increased susceptibility to injury 0.530112503830645 1 0.784483704597827 0.230769230769231 14.1 14 1 abnormal nerve conduction 0.559172796312993 1 0.784483704597827 0.230769230769231 14.1 14 1 increased spleen weight 0.508455882556815 1 0.782169593374825 0.230088495575221 14.1 14 1 decreased T cell proliferation 0.503934086125541 1 0.780949994216756 0.22972972972973 14.1 14 1 abnormal cardiovascular system morphology 0.543814699174974 1 0.779035901093676 0.229166666666667 14.1 14 1 abnormal kidney physiology 0.543814699174974 1 0.779035901093676 0.229166666666667 14.1 14 1 thick epidermis 0.536424732622702 1 0.777012431220705 0.228571428571429 14.1 14 1 abnormal artery morphology 0.558468164004205 1 0.777012431220705 0.228571428571429 14.1 14 1 abnormal intestinal goblet cell morphology 0.558468164004205 1 0.777012431220705 0.228571428571429 14.1 14 1 abnormal craniofacial bone morphology 0.546010651872678 1 0.775308456590835 0.228070175438596 14.1 14 1 abnormal facial morphology 0.546010651872678 1 0.775308456590835 0.228070175438596 14.1 14 1 abnormal circulating amino acid level 0.546010651872678 1 0.775308456590835 0.228070175438596 14.1 14 1 lung inflammation 0.526378492579532 1 0.774869933708148 0.227941176470588 14.1 14 1 increased neutrophil cell number 0.529177518521634 1 0.773663239706823 0.227586206896552 14.1 14 1 abnormal basisphenoid bone morphology 0.58263367238038 1 0.772597587861497 0.227272727272727 14.1 14 1 abnormal long bone epiphysis morphology 0.58263367238038 1 0.772597587861497 0.227272727272727 14.1 14 1 hypertension 0.558767197620226 1 0.772597587861497 0.227272727272727 14.1 14 1 intestinal ulcer 0.58263367238038 1 0.772597587861497 0.227272727272727 14.1 14 1 increased body size 0.58263367238038 1 0.772597587861497 0.227272727272727 14.1 14 1 abnormal tail movements 0.58263367238038 1 0.772597587861497 0.227272727272727 14.1 14 1 abnormal myelopoiesis 0.558767197620226 1 0.772597587861497 0.227272727272727 14.1 14 1 intestinal inflammation 0.58263367238038 1 0.772597587861497 0.227272727272727 14.1 14 1 short femur 0.541808699830918 1 0.772597587861497 0.227272727272727 14.1 14 1 decreased cardiac output 0.58263367238038 1 0.772597587861497 0.227272727272727 14.1 14 1 abnormal female reproductive system physiology 0.58263367238038 1 0.772597587861497 0.227272727272727 14.1 14 1 abnormal retinal layer morphology 0.58263367238038 1 0.772597587861497 0.227272727272727 14.1 14 1 decreased susceptibility to viral infection induced morbidity/mortality 0.58263367238038 1 0.772597587861497 0.227272727272727 14.1 14 1 abnormal cerebral cortex pyramidal cell morphology 0.58263367238038 1 0.772597587861497 0.227272727272727 14.1 14 1 increased bone volume 0.58263367238038 1 0.772597587861497 0.227272727272727 14.1 14 1 abnormal lung morphology 0.540048778365626 1 0.771299104520553 0.226890756302521 14.1 14 1 decreased exploration in new environment 0.552207906642164 1 0.768918551728823 0.226190476190476 14.1 14 1 abnormal cranial ganglia morphology 0.577565570501079 1 0.767613087294648 0.225806451612903 14.1 14 1 abnormal CD8-positive, alpha beta T cell morphology 0.577565570501079 1 0.767613087294648 0.225806451612903 14.1 14 1 increased fluid intake 0.574219588338747 1 0.763137209234621 0.224489795918367 14.1 14 1 abnormal enzyme/coenzyme level 0.573951794794817 1 0.761941069408235 0.224137931034483 14.1 14 1 abnormal femur morphology 0.574133214634913 1 0.761066280579982 0.223880597014925 14.1 14 1 internal hemorrhage 0.574133214634913 1 0.761066280579982 0.223880597014925 14.1 14 1 reduced long term potentiation 0.577898882874597 1 0.75880120236397 0.223214285714286 14.1 14 1 rectal prolapse 0.599545549806764 1 0.755428752575686 0.222222222222222 14.1 14 1 abnormal small intestine morphology 0.588272577833111 1 0.755428752575686 0.222222222222222 14.1 14 1 abnormal reflex 0.593542302716608 1 0.755428752575686 0.222222222222222 14.1 14 1 abnormal type II pneumocyte morphology 0.599545549806764 1 0.755428752575686 0.222222222222222 14.1 14 1 decreased insulin secretion 0.586724791043793 1 0.755428752575686 0.222222222222222 14.1 14 1 cochlear outer hair cell degeneration 0.586712034955518 1 0.755428752575686 0.222222222222222 14.1 14 1 cardiomyopathy 0.590191126153233 1 0.755428752575686 0.222222222222222 14.1 14 1 abnormal liver physiology 0.607866622024884 1 0.747874465049929 0.22 14.1 14 1 short stride length 0.603737272675374 1 0.747874465049929 0.22 14.1 14 1 increased circulating chloride level 0.603737272675374 1 0.747874465049929 0.22 14.1 14 1 abnormal locomotor activation 0.608526474711903 1 0.747127337712216 0.21978021978022 14.1 14 1 short humerus 0.607732865387021 1 0.746216206812567 0.219512195121951 14.1 14 1 short ulna 0.607732865387021 1 0.746216206812567 0.219512195121951 14.1 14 1 hemopericardium 0.607732865387021 1 0.746216206812567 0.219512195121951 14.1 14 1 abnormal crypts of Lieberkuhn morphology 0.614184673752278 1 0.74362517831669 0.21875 14.1 14 1 abnormal heart atrium morphology 0.614184673752278 1 0.74362517831669 0.21875 14.1 14 1 abnormal platelet physiology 0.616134335746757 1 0.741693684347037 0.218181818181818 14.1 14 1 abnormal immune system morphology 0.620542361473678 1 0.739006388389258 0.217391304347826 14.1 14 1 hypotension 0.625443899057565 1 0.739006388389258 0.217391304347826 14.1 14 1 pancreas inflammation 0.625443899057565 1 0.739006388389258 0.217391304347826 14.1 14 1 abnormal cochlear ganglion morphology 0.625443899057565 1 0.739006388389258 0.217391304347826 14.1 14 1 increased susceptibility to age related obesity 0.625443899057565 1 0.739006388389258 0.217391304347826 14.1 14 1 abnormal lymphocyte physiology 0.620542361473678 1 0.739006388389258 0.217391304347826 14.1 14 1 abnormal regulatory T cell physiology 0.625443899057565 1 0.739006388389258 0.217391304347826 14.1 14 1 increased sensitivity to induced morbidity/mortality 0.654087096685734 1 0.739006388389258 0.217391304347826 14.1 14 1 abnormal palatal shelf fusion at midline 0.625443899057565 1 0.739006388389258 0.217391304347826 14.1 14 1 weight loss 0.654733579016153 1 0.73816180965967 0.217142857142857 14.1 14 1 abnormal eye physiology 0.627578353810371 1 0.736543033761293 0.216666666666667 14.1 14 1 abnormal humerus morphology 0.62718556937863 1 0.735011759262829 0.216216216216216 14.1 14 1 impaired hematopoiesis 0.632247186983799 1 0.733210259852871 0.215686274509804 14.1 14 1 decreased monocyte cell number 0.638217242946874 1 0.732184790957972 0.215384615384615 14.1 14 1 abnormal circulating cholesterol level 0.637831272741133 1 0.728449154269411 0.214285714285714 14.1 14 1 abnormal jaw morphology 0.637831272741133 1 0.728449154269411 0.214285714285714 14.1 14 1 increased circulating luteinizing hormone level 0.637831272741133 1 0.728449154269411 0.214285714285714 14.1 14 1 abnormal seminal vesicle morphology 0.643044718567334 1 0.728449154269411 0.214285714285714 14.1 14 1 abnormal spleen white pulp morphology 0.638937706601073 1 0.728449154269411 0.214285714285714 14.1 14 1 straub tail 0.637831272741133 1 0.728449154269411 0.214285714285714 14.1 14 1 enhanced coordination 0.637831272741133 1 0.728449154269411 0.214285714285714 14.1 14 1 abnormal cytotoxic T cell physiology 0.638937706601073 1 0.728449154269411 0.214285714285714 14.1 14 1 abnormal NK cell physiology 0.653081106449021 1 0.724468557797994 0.213114754098361 14.1 14 1 increased systemic arterial blood pressure 0.649698807737323 1 0.723282848210763 0.212765957446809 14.1 14 1 abnormal retinal pigment epithelium morphology 0.666334187317205 1 0.722378744650499 0.2125 14.1 14 1 absent vibrissae 0.649009541011805 1 0.721091082004063 0.212121212121212 14.1 14 1 decreased systemic arterial blood pressure 0.649009541011805 1 0.721091082004063 0.212121212121212 14.1 14 1 dilated heart atrium 0.649009541011805 1 0.721091082004063 0.212121212121212 14.1 14 1 abnormal QRS complex 0.649009541011805 1 0.721091082004063 0.212121212121212 14.1 14 1 decreased IgA level 0.65964917514684 1 0.719110062548008 0.211538461538462 14.1 14 1 decreased body temperature 0.65964917514684 1 0.719110062548008 0.211538461538462 14.1 14 1 abnormal retinal outer nuclear layer morphology 0.659246896621427 1 0.715669344545386 0.210526315789474 14.1 14 1 increased eosinophil cell number 0.67761215556241 1 0.712783581059316 0.209677419354839 14.1 14 1 abnormal organ of Corti morphology 0.668722387696122 1 0.711508476263146 0.209302325581395 14.1 14 1 abnormal blood circulation 0.668722387696122 1 0.711508476263146 0.209302325581395 14.1 14 1 apnea 0.665486995782865 1 0.708214455539705 0.208333333333333 14.1 14 1 abnormal sensory capabilities/reflexes/nociception 0.665486995782865 1 0.708214455539705 0.208333333333333 14.1 14 1 abnormal lymph node morphology 0.677563046832677 1 0.708214455539705 0.208333333333333 14.1 14 1 increased susceptibility to pharmacologically induced seizures 0.709008911679074 1 0.708214455539705 0.208333333333333 14.1 14 1 abnormal cardiac muscle contractility 0.665486995782865 1 0.708214455539705 0.208333333333333 14.1 14 1 decreased ovulation rate 0.665486995782865 1 0.708214455539705 0.208333333333333 14.1 14 1 hypopigmentation 0.665486995782865 1 0.708214455539705 0.208333333333333 14.1 14 1 abnormal lung saccule morphology 0.665486995782865 1 0.708214455539705 0.208333333333333 14.1 14 1 abnormal coat/ hair morphology 0.685863108961089 1 0.70554194816031 0.207547169811321 14.1 14 1 abnormal pancreatic islet morphology 0.685863108961089 1 0.70554194816031 0.207547169811321 14.1 14 1 decreased IgG level 0.727863108823793 1 0.704386269293545 0.207207207207207 14.1 14 1 abnormal microglial cell morphology 0.673845216085062 1 0.703330217915293 0.206896551724138 14.1 14 1 abnormal spinal nerve morphology 0.673845216085062 1 0.703330217915293 0.206896551724138 14.1 14 1 abnormal outer ear morphology 0.673845216085062 1 0.703330217915293 0.206896551724138 14.1 14 1 decreased bone strength 0.673845216085062 1 0.703330217915293 0.206896551724138 14.1 14 1 glomerulosclerosis 0.693694906614021 1 0.703330217915293 0.206896551724138 14.1 14 1 abnormal vision 0.681897809572706 1 0.69988252076865 0.205882352941176 14.1 14 1 abnormal bone remodeling 0.681897809572706 1 0.69988252076865 0.205882352941176 14.1 14 1 decreased pancreatic beta cell number 0.681897809572706 1 0.69988252076865 0.205882352941176 14.1 14 1 increased width of hypertrophic chondrocyte zone 0.681897809572706 1 0.69988252076865 0.205882352941176 14.1 14 1 decreased osteoblast cell number 0.681897809572706 1 0.69988252076865 0.205882352941176 14.1 14 1 decreased cytotoxic T cell cytolysis 0.681897809572706 1 0.69988252076865 0.205882352941176 14.1 14 1 acanthosis 0.689613939234448 1 0.697318848531402 0.205128205128205 14.1 14 1 increased autoantibody level 0.689613939234448 1 0.697318848531402 0.205128205128205 14.1 14 1 impaired macrophage chemotaxis 0.689613939234448 1 0.697318848531402 0.205128205128205 14.1 14 1 cochlear hair cell degeneration 0.696996579429924 1 0.695337829075347 0.204545454545455 14.1 14 1 organ of Corti degeneration 0.704061369523428 1 0.693761099304201 0.204081632653061 14.1 14 1 increased B cell proliferation 0.717317303321242 1 0.691409366764187 0.203389830508475 14.1 14 1 abnormal coat appearance 0.729539861499978 1 0.689739295829974 0.202898550724638 14.1 14 1 increased lymphocyte cell number 0.729539861499978 1 0.689739295829974 0.202898550724638 14.1 14 1 abnormal response to infection 0.740868039628502 1 0.688492027663916 0.20253164556962 14.1 14 1 abnormal blood homeostasis 0.774956610346134 1 0.685849788522662 0.201754385964912 14.1 14 1 abnormal autopod morphology 0.723697942749097 1 0.679885877318117 0.2 14.1 14 1 abnormal humoral immune response 0.781400158020175 1 0.679885877318117 0.2 14.1 14 1 salivary gland inflammation 0.707469828993981 1 0.679885877318117 0.2 14.1 14 1 abnormal lactation 0.707469828993981 1 0.679885877318117 0.2 14.1 14 1 decreased circulating alkaline phosphatase level 0.729142393735442 1 0.679885877318117 0.2 14.1 14 1 diaphragmatic hernia 0.702615805539414 1 0.679885877318117 0.2 14.1 14 1 decreased bone mineralization 0.712755220964831 1 0.679885877318117 0.2 14.1 14 1 abnormal dendritic cell physiology 0.810132226765548 1 0.667177730078526 0.196261682242991 14.1 14 1 delayed wound healing 0.748789840897171 1 0.665105749550332 0.195652173913043 14.1 14 1 abnormal response/metabolism to endogenous compounds 0.794022424157144 1 0.663303294944504 0.195121951219512 14.1 14 1 abnormal systemic arterial blood pressure 0.741530752955781 1 0.661000158503725 0.194444444444444 14.1 14 1 abnormal epidermis stratum granulosum morphology 0.741530752955781 1 0.661000158503725 0.194444444444444 14.1 14 1 head tilt 0.741530752955781 1 0.661000158503725 0.194444444444444 14.1 14 1 abnormal nose morphology 0.738646851032278 1 0.657954074823984 0.193548387096774 14.1 14 1 pale kidney 0.738646851032278 1 0.657954074823984 0.193548387096774 14.1 14 1 abnormal T cell proliferation 0.738646851032278 1 0.657954074823984 0.193548387096774 14.1 14 1 decreased susceptibility to bacterial infection induced morbidity/mortality 0.738646851032278 1 0.657954074823984 0.193548387096774 14.1 14 1 decreased susceptibility to induced arthritis 0.777886165198161 1 0.656030232499937 0.192982456140351 14.1 14 1 abnormal stomach morphology 0.736768902974276 1 0.653736420498189 0.192307692307692 14.1 14 1 abnormal kidney cortex morphology 0.736768902974276 1 0.653736420498189 0.192307692307692 14.1 14 1 abnormal ureter morphology 0.736768902974276 1 0.653736420498189 0.192307692307692 14.1 14 1 no spontaneous movement 0.736768902974276 1 0.653736420498189 0.192307692307692 14.1 14 1 increased percent body fat/body weight 0.774948274764583 1 0.653736420498189 0.192307692307692 14.1 14 1 abnormal innervation 0.772258769803452 1 0.650954563389686 0.191489361702128 14.1 14 1 abnormal long bone metaphysis morphology 0.76821129579045 1 0.643135289354975 0.189189189189189 14.1 14 1 abnormal hair follicle development 0.76821129579045 1 0.643135289354975 0.189189189189189 14.1 14 1 increased dopamine level 0.767368891943047 1 0.637393009985735 0.1875 14.1 14 1 abnormal colon morphology 0.815986443749347 1 0.633791919533838 0.186440677966102 14.1 14 1 impaired macrophage phagocytosis 0.793084050701827 1 0.632451978900574 0.186046511627907 14.1 14 1 abnormal brain commissure morphology 0.767956028694165 1 0.629523960479738 0.185185185185185 14.1 14 1 cryptorchism 0.767956028694165 1 0.629523960479738 0.185185185185185 14.1 14 1 abnormal palate morphology 0.767956028694165 1 0.629523960479738 0.185185185185185 14.1 14 1 abnormal bone trabecula morphology 0.767956028694165 1 0.629523960479738 0.185185185185185 14.1 14 1 abnormal frontal bone morphology 0.792816160118939 1 0.626210676477213 0.184210526315789 14.1 14 1 incomplete somite formation 0.792816160118939 1 0.626210676477213 0.184210526315789 14.1 14 1 abnormal aorta morphology 0.793670969927767 1 0.618078070289197 0.181818181818182 14.1 14 1 abnormal joint morphology 0.83282380223306 1 0.618078070289197 0.181818181818182 14.1 14 1 increased liver weight 0.876127739806009 1 0.618078070289197 0.181818181818182 14.1 14 1 decreased macrophage cell number 0.814436822095583 1 0.618078070289197 0.181818181818182 14.1 14 1 diarrhea 0.793670969927767 1 0.618078070289197 0.181818181818182 14.1 14 1 abnormal middle ear ossicle morphology 0.793670969927767 1 0.618078070289197 0.181818181818182 14.1 14 1 decreased sensitivity to induced morbidity/mortality 0.814436822095583 1 0.618078070289197 0.181818181818182 14.1 14 1 myeloid hyperplasia 0.793670969927767 1 0.618078070289197 0.181818181818182 14.1 14 1 abnormal response to injury 0.815391645937421 1 0.610153992464977 0.179487179487179 14.1 14 1 hypoxia 0.796244019118737 1 0.607040961891176 0.178571428571429 14.1 14 1 decreased regulatory T cell number 0.817622361432424 1 0.599899303515986 0.176470588235294 14.1 14 1 increased susceptibility to viral infection induced morbidity/mortality 0.817622361432424 1 0.599899303515986 0.176470588235294 14.1 14 1 abnormal T cell activation 0.887530675955778 1 0.597197054401049 0.175675675675676 14.1 14 1 abnormal skin pigmentation 0.836005847246066 1 0.594900142653352 0.175 14.1 14 1 abnormal pancreatic beta cell morphology 0.836005847246066 1 0.594900142653352 0.175 14.1 14 1 focal hair loss 0.821743769750753 1 0.586108514929411 0.172413793103448 14.1 14 1 enlarged epididymis 0.821743769750753 1 0.586108514929411 0.172413793103448 14.1 14 1 decreased eosinophil cell number 0.889541796785976 1 0.584276925820257 0.171875 14.1 14 1 scaly skin 0.854743817978751 1 0.580390383076441 0.170731707317073 14.1 14 1 abnormal cochlea morphology 0.893561178507349 1 0.566571564431764 0.166666666666667 14.1 14 1 gastrointestinal hemorrhage 0.844598557902108 1 0.566571564431764 0.166666666666667 14.1 14 1 abnormal inflammatory response 0.918859778054198 1 0.566571564431764 0.166666666666667 14.1 14 1 emphysema 0.844598557902108 1 0.566571564431764 0.166666666666667 14.1 14 1 abnormal vibrissa morphology 0.871703182150627 1 0.566571564431764 0.166666666666667 14.1 14 1 liver hemorrhage 0.844598557902108 1 0.566571564431764 0.166666666666667 14.1 14 1 abnormal osteoclast morphology 0.883216144383436 1 0.566571564431764 0.166666666666667 14.1 14 1 increased susceptibility to bacterial infection induced morbidity/mortality 0.918859778054198 1 0.566571564431764 0.166666666666667 14.1 14 1 abnormal T-helper 2 physiology 0.905444578213188 1 0.556270263260278 0.163636363636364 14.1 14 1 abnormal pancreatic beta cell physiology 0.876424798386102 1 0.551258819447122 0.162162162162162 14.1 14 1 deafness 0.958220342442419 1 0.549402729145953 0.161616161616162 14.1 14 1 osteopetrosis 0.864973886146305 1 0.54829506235332 0.161290322580645 14.1 14 1 abnormal immune system physiology 0.972741100054809 1 0.54829506235332 0.161290322580645 14.1 14 1 abnormal retinal photoreceptor layer morphology 0.864973886146305 1 0.54829506235332 0.161290322580645 14.1 14 1 abnormal long term potentiation 0.883048885072835 1 0.531160841654779 0.15625 14.1 14 1 decreased susceptibility to parasitic infection 0.883048885072835 1 0.531160841654779 0.15625 14.1 14 1 abnormal serotonin level 0.883048885072835 1 0.531160841654779 0.15625 14.1 14 1 abnormal cytokine secretion 0.989277953945727 1 0.529781203105026 0.155844155844156 14.1 14 1 altered response to myocardial infarction 0.91299612598845 1 0.52880012680298 0.155555555555556 14.1 14 1 decreased osteoclast cell number 0.91299612598845 1 0.52880012680298 0.155555555555556 14.1 14 1 abnormal lens fiber morphology 0.906048649356427 1 0.522989136398551 0.153846153846154 14.1 14 1 head tossing 0.899009227063025 1 0.515065058574331 0.151515151515152 14.1 14 1 decreased sensitivity to xenobiotic induced morbidity/mortality 0.899009227063025 1 0.515065058574331 0.151515151515152 14.1 14 1 head bobbing 0.918409143846491 1 0.509914407988588 0.15 14.1 14 1 impaired behavioral response to xenobiotic 0.925328517623675 1 0.485632769512941 0.142857142857143 14.1 14 1 abnormal digestive system physiology 0.956584391805301 1 0.475920114122682 0.14 14.1 14 1 kidney failure 0.947348638750127 1 0.47433898417543 0.13953488372093 14.1 14 1 abnormal uterus morphology 0.936046558719421 1 0.472142970359803 0.138888888888889 14.1 14 1 small lens 0.960400499316953 1 0.435824280332126 0.128205128205128 14.1 14 1 abnormal leukocyte adhesion 0.960400499316953 1 0.435824280332126 0.128205128205128 14.1 14 1 impaired natural killer cell mediated cytotoxicity 0.984928507367963 1 0.417473784318142 0.12280701754386 14.1 14 1 increased susceptibility to parasitic infection 0.998521370037995 1 0.377714376287843 0.111111111111111 14.1 14 1 decreased inflammatory response 0.998583257596896 1 0.364224577134706 0.107142857142857 14.1 14 1 abnormal thymus involution 4.53474892245001e-05 0.00054625607479876 1.30071210579858 1 15.3 15 3 abnormal AMPA-mediated synaptic currents 4.53474892245001e-05 0.00054625607479876 1.30071210579858 1 15.3 15 3 absent ovary 4.53474892245001e-05 0.00054625607479876 1.30071210579858 1 15.3 15 3 decreased red blood cell distribution width 4.53474892245001e-05 0.00054625607479876 1.30071210579858 1 15.3 15 3 abnormal fear/anxiety-related behavior 0.000104375553282915 0.0011462878092329 1.30071210579858 1 15.3 15 3 ketoaciduria 0.000240230235089025 0.00238076776806354 1.30071210579858 1 15.3 15 3 abnormal spinal cord dorsal column morphology 0.000240230235089025 0.00238076776806354 1.30071210579858 1 15.3 15 3 thin ventricle myocardium compact layer 0.000240230235089025 0.00238076776806354 1.30071210579858 1 15.3 15 3 heart hyperplasia 0.000552891451075209 0.00475888402958333 1.30071210579858 1 15.3 15 3 increased pheochromocytoma incidence 0.000552891451075209 0.00475888402958333 1.30071210579858 1 15.3 15 3 abnormal posterior semicircular canal morphology 0.000552891451075209 0.00475888402958333 1.30071210579858 1 15.3 15 3 polycythemia 0.000552891451075209 0.00475888402958333 1.30071210579858 1 15.3 15 3 abnormal NMDA-mediated synaptic currents 0.000552891451075209 0.00475888402958333 1.30071210579858 1 15.3 15 3 decreased fear-related response 0.000552891451075209 0.00475888402958333 1.30071210579858 1 15.3 15 3 decreased cellular sensitivity to ionizing radiation 0.000552891451075209 0.00475888402958333 1.30071210579858 1 15.3 15 3 decreased vestibular hair cell number 0.000552891451075209 0.00475888402958333 1.30071210579858 1 15.3 15 3 liver hyperplasia 0.000552891451075209 0.00475888402958333 1.30071210579858 1 15.3 15 3 increased cardiac muscle glycogen level 0.000552891451075209 0.00475888402958333 1.30071210579858 1 15.3 15 3 absent mammary gland 0.00127243444762616 0.00935060764688356 1.30071210579858 1 15.3 15 3 decreased aerobic running capacity 0.00127243444762616 0.00935060764688356 1.30071210579858 1 15.3 15 3 abnormal neuron apoptosis 0.00127243444762616 0.00935060764688356 1.30071210579858 1 15.3 15 3 colon polyps 0.00127243444762616 0.00935060764688356 1.30071210579858 1 15.3 15 3 liver failure 0.00127243444762616 0.00935060764688356 1.30071210579858 1 15.3 15 3 accumulation of giant lysosomes in kidney/renal tubule cells 0.00127243444762616 0.00935060764688356 1.30071210579858 1 15.3 15 3 craniofacial phenotype 0.00127243444762616 0.00935060764688356 1.30071210579858 1 15.3 15 3 absent outer ear 0.00127243444762616 0.00935060764688356 1.30071210579858 1 15.3 15 3 decreased alveolar lamellar body number 0.00127243444762616 0.00935060764688356 1.30071210579858 1 15.3 15 3 increased aorta wall thickness 0.00127243444762616 0.00935060764688356 1.30071210579858 1 15.3 15 3 mammary gland hyperplasia 0.00292829143439657 0.0184341609005404 1.30071210579858 1 15.3 15 3 excessive tearing 0.00292829143439657 0.0184341609005404 1.30071210579858 1 15.3 15 3 abnormal circulating alanine transaminase level 0.00292829143439657 0.0184341609005404 1.30071210579858 1 15.3 15 3 abnormal inhibitory postsynaptic potential 0.00292829143439657 0.0184341609005404 1.30071210579858 1 15.3 15 3 decreased cardiomyocyte apoptosis 0.00292829143439657 0.0184341609005404 1.30071210579858 1 15.3 15 3 abnormal central pattern generator function 0.00292829143439657 0.0184341609005404 1.30071210579858 1 15.3 15 3 abnormal Purkinje cell innervation 0.00292829143439657 0.0184341609005404 1.30071210579858 1 15.3 15 3 increased oligodendrocyte number 0.00292829143439657 0.0184341609005404 1.30071210579858 1 15.3 15 3 abnormal retina inner limiting membrane morphology 0.00292829143439657 0.0184341609005404 1.30071210579858 1 15.3 15 3 fragmented Meckel's cartilage 0.00292829143439657 0.0184341609005404 1.30071210579858 1 15.3 15 3 embryo tumor 0.00292829143439657 0.0184341609005404 1.30071210579858 1 15.3 15 3 arrest of tooth development 0.00673870607720081 0.0347770360311971 1.30071210579858 1 15.3 15 3 hyperresponsive 0.00673870607720081 0.0347770360311971 1.30071210579858 1 15.3 15 3 jumpy 0.00673870607720081 0.0347770360311971 1.30071210579858 1 15.3 15 3 delayed brain development 0.00673870607720081 0.0347770360311971 1.30071210579858 1 15.3 15 3 chromatolysis 0.00673870607720081 0.0347770360311971 1.30071210579858 1 15.3 15 3 increased post-tetanic potentiation 0.00673870607720081 0.0347770360311971 1.30071210579858 1 15.3 15 3 decreased posterior semicircular canal size 0.00673870607720081 0.0347770360311971 1.30071210579858 1 15.3 15 3 loss of hippocampal neurons 0.00673870607720081 0.0347770360311971 1.30071210579858 1 15.3 15 3 decreased liver function 0.00673870607720081 0.0347770360311971 1.30071210579858 1 15.3 15 3 increased glycerol level 0.00673870607720081 0.0347770360311971 1.30071210579858 1 15.3 15 3 vestibular saccular degeneration 0.00673870607720081 0.0347770360311971 1.30071210579858 1 15.3 15 3 osteomyelitis 0.00673870607720081 0.0347770360311971 1.30071210579858 1 15.3 15 3 abnormal heart size 0.00673870607720081 0.0347770360311971 1.30071210579858 1 15.3 15 3 decreased platelet ADP level 0.00673870607720081 0.0347770360311971 1.30071210579858 1 15.3 15 3 absent tongue 0.00673870607720081 0.0347770360311971 1.30071210579858 1 15.3 15 3 abnormal olfactory bulb layer morphology 0.00673870607720081 0.0347770360311971 1.30071210579858 1 15.3 15 3 ectopic hippocampus pyramidal cells 0.00673870607720081 0.0347770360311971 1.30071210579858 1 15.3 15 3 abnormal endocrine pancreas development 0.00673870607720081 0.0347770360311971 1.30071210579858 1 15.3 15 3 increased bone trabecular spacing 0.00673870607720081 0.0347770360311971 1.30071210579858 1 15.3 15 3 decreased hippocampus volume 0.00673870607720081 0.0347770360311971 1.30071210579858 1 15.3 15 3 small hair follicles 0.015506795890948 0.0649926786499296 1.30071210579858 1 15.3 15 3 skin hyperplasia 0.015506795890948 0.0649926786499296 1.30071210579858 1 15.3 15 3 increased hepatic hemangioma incidence 0.015506795890948 0.0649926786499296 1.30071210579858 1 15.3 15 3 abnormal nasal mucosa morphology 0.015506795890948 0.0649926786499296 1.30071210579858 1 15.3 15 3 improved righting response 0.015506795890948 0.0649926786499296 1.30071210579858 1 15.3 15 3 absent malleus processus brevis 0.015506795890948 0.0649926786499296 1.30071210579858 1 15.3 15 3 decreased lysosomal enzyme secretion 0.015506795890948 0.0649926786499296 1.30071210579858 1 15.3 15 3 increased lysosomal enzyme secretion 0.015506795890948 0.0649926786499296 1.30071210579858 1 15.3 15 3 enhanced NMDA-mediated synaptic currents 0.015506795890948 0.0649926786499296 1.30071210579858 1 15.3 15 3 gastric polyps 0.015506795890948 0.0649926786499296 1.30071210579858 1 15.3 15 3 absent uterus 0.015506795890948 0.0649926786499296 1.30071210579858 1 15.3 15 3 abnormal hypodermis morphology 0.015506795890948 0.0649926786499296 1.30071210579858 1 15.3 15 3 ectopic cartilage 0.015506795890948 0.0649926786499296 1.30071210579858 1 15.3 15 3 increased heart right ventricle weight 0.015506795890948 0.0649926786499296 1.30071210579858 1 15.3 15 3 abnormal Descemet membrane 0.015506795890948 0.0649926786499296 1.30071210579858 1 15.3 15 3 absent frontal bone 0.015506795890948 0.0649926786499296 1.30071210579858 1 15.3 15 3 abnormal tail pigmentation 0.015506795890948 0.0649926786499296 1.30071210579858 1 15.3 15 3 increased placenta apoptosis 0.015506795890948 0.0649926786499296 1.30071210579858 1 15.3 15 3 enhanced behavioral response to anesthetic 0.015506795890948 0.0649926786499296 1.30071210579858 1 15.3 15 3 enlarged eye anterior chamber 0.015506795890948 0.0649926786499296 1.30071210579858 1 15.3 15 3 abnormal olfactory bulb granule cell layer morphology 0.015506795890948 0.0649926786499296 1.30071210579858 1 15.3 15 3 decreased DN3 thymocyte number 0.015506795890948 0.0649926786499296 1.30071210579858 1 15.3 15 3 increased response to stress-induced hyperthermia 0.015506795890948 0.0649926786499296 1.30071210579858 1 15.3 15 3 increased mammary gland epithelial cell proliferation 0.015506795890948 0.0649926786499296 1.30071210579858 1 15.3 15 3 increased T follicular helper cell number 0.015506795890948 0.0649926786499296 1.30071210579858 1 15.3 15 3 increased renal carcinoma incidence 0.015506795890948 0.0649926786499296 1.30071210579858 1 15.3 15 3 aorta hypoplasia 0.015506795890948 0.0649926786499296 1.30071210579858 1 15.3 15 3 enlarged aortic valve 0.015506795890948 0.0649926786499296 1.30071210579858 1 15.3 15 3 abnormal paranode morphology 0.015506795890948 0.0649926786499296 1.30071210579858 1 15.3 15 3 pale lung 0.015506795890948 0.0649926786499296 1.30071210579858 1 15.3 15 3 alveolitis 0.015506795890948 0.0649926786499296 1.30071210579858 1 15.3 15 3 abnormal lung alveolus development 0.015506795890948 0.0649926786499296 1.30071210579858 1 15.3 15 3 decreased pre-pro B cell number 0.015506795890948 0.0649926786499296 1.30071210579858 1 15.3 15 3 cerebral edema 0.015506795890948 0.0649926786499296 1.30071210579858 1 15.3 15 3 decreased platelet alpha-granule number 0.015506795890948 0.0649926786499296 1.30071210579858 1 15.3 15 3 decreased paired-pulse facilitation 1.55496520383565e-06 2.78271650686415e-05 1.23567650050865 0.95 15.3 15 3 abnormal postnatal subventricular zone morphology 1.55496520383565e-06 2.78271650686415e-05 1.23567650050865 0.95 15.3 15 3 reduced long term depression 1.02609996523419e-10 4.019564824441e-09 1.2284503221431 0.944444444444444 15.3 15 3 increased effector memory CD4-positive, alpha-beta T cell number 7.44780416193823e-06 0.000112281290017099 1.2284503221431 0.944444444444444 15.3 15 3 impaired synaptic plasticity 4.86096620813852e-10 1.70304978066825e-08 1.22419962898689 0.941176470588235 15.3 15 3 abnormal bone marrow cavity morphology 1.623177738512e-05 0.000226834529469022 1.22419962898689 0.941176470588235 15.3 15 3 absence seizures 1.623177738512e-05 0.000226834529469022 1.22419962898689 0.941176470588235 15.3 15 3 impaired somite development 3.52622109990124e-05 0.000450975577686598 1.21941759918616 0.9375 15.3 15 3 abnormal synaptic transmission 1.06744486114279e-08 2.82475435329011e-07 1.213997965412 0.933333333333333 15.3 15 3 abnormal seizure response to electrical stimulation 7.63289204242802e-05 0.000865003141482447 1.213997965412 0.933333333333333 15.3 15 3 delayed intramembranous bone ossification 7.63289204242802e-05 0.000865003141482447 1.213997965412 0.933333333333333 15.3 15 3 increased hemangioma incidence 0.000164551541017183 0.0017266431192442 1.20780409824153 0.928571428571429 15.3 15 3 increased circulating growth hormone level 0.000164551541017183 0.0017266431192442 1.20780409824153 0.928571428571429 15.3 15 3 abnormal renal tubule epithelial cell primary cilium morphology 0.000164551541017183 0.0017266431192442 1.20780409824153 0.928571428571429 15.3 15 3 abnormal contextual conditioning behavior 1.24269031978367e-14 8.35457343368076e-13 1.2061148617405 0.927272727272727 15.3 15 3 decreased susceptibility to pharmacologically induced seizures 1.05832695725328e-07 2.47191390250472e-06 1.20436306092461 0.925925925925926 15.3 15 3 increased synaptic depression 0.000353103857178033 0.00330205204785849 1.20065732842945 0.923076923076923 15.3 15 3 abnormal retinal inner plexiform layer morphology 0.000353103857178033 0.00330205204785849 1.20065732842945 0.923076923076923 15.3 15 3 abnormal impulse conducting system conduction 1.02379963366461e-06 1.88644562128943e-05 1.19231943031536 0.916666666666667 15.3 15 3 abnormal mating frequency 0.000753684257925482 0.00605747848655779 1.19231943031536 0.916666666666667 15.3 15 3 abnormal embryonic growth/weight/body size 0.000753684257925482 0.00605747848655779 1.19231943031536 0.916666666666667 15.3 15 3 abnormal respiratory function 0.000753684257925482 0.00605747848655779 1.19231943031536 0.916666666666667 15.3 15 3 abnormal corticospinal tract morphology 0.000753684257925482 0.00605747848655779 1.19231943031536 0.916666666666667 15.3 15 3 decreased synaptic depression 0.000753684257925482 0.00605747848655779 1.19231943031536 0.916666666666667 15.3 15 3 increased osteosarcoma incidence 0.000753684257925482 0.00605747848655779 1.19231943031536 0.916666666666667 15.3 15 3 stria vascularis degeneration 0.000753684257925482 0.00605747848655779 1.19231943031536 0.916666666666667 15.3 15 3 prenatal growth retardation 0.000753684257925482 0.00605747848655779 1.19231943031536 0.916666666666667 15.3 15 3 abnormal locomotor coordination 1.46020669852669e-08 3.76400431355973e-07 1.18246555072598 0.909090909090909 15.3 15 3 increased coping response 4.57111740652705e-06 7.3596469571107e-05 1.18246555072598 0.909090909090909 15.3 15 3 abnormal channel response 4.57111740652705e-06 7.3596469571107e-05 1.18246555072598 0.909090909090909 15.3 15 3 abnormal hypothalamus secretion 0.00159877705315012 0.0111869421088915 1.18246555072598 0.909090909090909 15.3 15 3 pharyngeal arch hypoplasia 0.00159877705315012 0.0111869421088915 1.18246555072598 0.909090909090909 15.3 15 3 abnormal spinal cord ventral horn morphology 0.00159877705315012 0.0111869421088915 1.18246555072598 0.909090909090909 15.3 15 3 reduced sympathetic cervical ganglion size 0.00159877705315012 0.0111869421088915 1.18246555072598 0.909090909090909 15.3 15 3 abnormal embryonic/fetal subventricular zone morphology 9.60199781827017e-06 0.000140499821017336 1.17683476238919 0.904761904761905 15.3 15 3 abnormal brain wave pattern 1.54601123759205e-12 7.69140590702047e-11 1.17564363408717 0.903846153846154 15.3 15 3 abnormal cell differentiation 4.49045034473161e-10 1.58439648688225e-08 1.17381336376945 0.902439024390244 15.3 15 3 enhanced paired-pulse facilitation 1.33803165250237e-07 3.08180901444412e-06 1.17064089521872 0.9 15.3 15 3 abnormal heart right ventricle morphology 2.00805708098511e-05 0.000273700930901395 1.17064089521872 0.9 15.3 15 3 jaundice 0.00336684239495087 0.0199881156502155 1.17064089521872 0.9 15.3 15 3 fused cornea and lens 0.00336684239495087 0.0199881156502155 1.17064089521872 0.9 15.3 15 3 alcohol preference 0.00336684239495087 0.0199881156502155 1.17064089521872 0.9 15.3 15 3 impaired basement membrane formation 0.00336684239495087 0.0199881156502155 1.17064089521872 0.9 15.3 15 3 intestinal hypoperistalsis 0.00336684239495087 0.0199881156502155 1.17064089521872 0.9 15.3 15 3 abnormal submandibular gland morphology 0.00336684239495087 0.0199881156502155 1.17064089521872 0.9 15.3 15 3 increased atrioventricular cushion size 0.00336684239495087 0.0199881156502155 1.17064089521872 0.9 15.3 15 3 abnormal hindlimb zeugopod morphology 0.00336684239495087 0.0199881156502155 1.17064089521872 0.9 15.3 15 3 absent pharyngeal arches 0.00336684239495087 0.0199881156502155 1.17064089521872 0.9 15.3 15 3 increased heart rate variability 0.00336684239495087 0.0199881156502155 1.17064089521872 0.9 15.3 15 3 abnormal plasma membrane morphology 0.00336684239495087 0.0199881156502155 1.17064089521872 0.9 15.3 15 3 abnormal respiratory conducting tube morphology 0.00336684239495087 0.0199881156502155 1.17064089521872 0.9 15.3 15 3 osteosclerosis 0.00336684239495087 0.0199881156502155 1.17064089521872 0.9 15.3 15 3 abnormal hippocampus neuron morphology 0.00336684239495087 0.0199881156502155 1.17064089521872 0.9 15.3 15 3 fusion of atlas and odontoid process 0.00336684239495087 0.0199881156502155 1.17064089521872 0.9 15.3 15 3 lethality during fetal growth through weaning, complete penetrance 0.00336684239495087 0.0199881156502155 1.17064089521872 0.9 15.3 15 3 absent long term depression 2.78174701580098e-07 5.94792104731847e-06 1.16615568106079 0.896551724137931 15.3 15 3 decreased neuron apoptosis 4.02957580875633e-09 1.19328212193826e-07 1.1637950420303 0.894736842105263 15.3 15 3 abnormal stationary movement 4.17901705406969e-05 0.000510825794692794 1.1637950420303 0.894736842105263 15.3 15 3 delayed sexual maturation 4.17901705406969e-05 0.000510825794692794 1.1637950420303 0.894736842105263 15.3 15 3 abnormal digestive system development 4.17901705406969e-05 0.000510825794692794 1.1637950420303 0.894736842105263 15.3 15 3 maternal imprinting 4.17901705406969e-05 0.000510825794692794 1.1637950420303 0.894736842105263 15.3 15 3 myoclonus 5.76221702661007e-07 1.11980584794473e-05 1.16135009446301 0.892857142857143 15.3 15 3 abnormal nervous system electrophysiology 1.58461915198003e-18 1.97087007027516e-16 1.16135009446301 0.892857142857143 15.3 15 3 abnormal excitatory postsynaptic potential 6.72908313147072e-18 7.43937523979263e-16 1.15795102101581 0.890243902439024 15.3 15 3 trabecula carnea hypoplasia 2.54231043723381e-10 9.3942900104745e-09 1.15618853848762 0.888888888888889 15.3 15 3 abnormal atrioventricular cushion morphology 1.18896401615863e-06 2.1587941534267e-05 1.15618853848762 0.888888888888889 15.3 15 3 abnormal fetal cardiomyocyte proliferation 1.18896401615863e-06 2.1587941534267e-05 1.15618853848762 0.888888888888889 15.3 15 3 abnormal thymus cortex morphology 8.65035631705739e-05 0.00097145649384561 1.15618853848762 0.888888888888889 15.3 15 3 abnormal bile duct morphology 8.65035631705739e-05 0.00097145649384561 1.15618853848762 0.888888888888889 15.3 15 3 primary atelectasis 8.65035631705739e-05 0.00097145649384561 1.15618853848762 0.888888888888889 15.3 15 3 abnormal ion homeostasis 0.0070287784200338 0.0354646781335377 1.15618853848762 0.888888888888889 15.3 15 3 biliary cyst 0.0070287784200338 0.0354646781335377 1.15618853848762 0.888888888888889 15.3 15 3 pancreas cysts 0.0070287784200338 0.0354646781335377 1.15618853848762 0.888888888888889 15.3 15 3 abnormal artery development 0.0070287784200338 0.0354646781335377 1.15618853848762 0.888888888888889 15.3 15 3 premature neuronal precursor differentiation 0.0070287784200338 0.0354646781335377 1.15618853848762 0.888888888888889 15.3 15 3 abnormal thymus physiology 0.0070287784200338 0.0354646781335377 1.15618853848762 0.888888888888889 15.3 15 3 increased neuronal precursor cell number 0.0070287784200338 0.0354646781335377 1.15618853848762 0.888888888888889 15.3 15 3 abnormal CNS synapse formation 0.0070287784200338 0.0354646781335377 1.15618853848762 0.888888888888889 15.3 15 3 abnormal intervertebral disk development 0.0070287784200338 0.0354646781335377 1.15618853848762 0.888888888888889 15.3 15 3 abnormal inguinal fat pad morphology 0.0070287784200338 0.0354646781335377 1.15618853848762 0.888888888888889 15.3 15 3 abnormal liver vasculature morphology 0.0070287784200338 0.0354646781335377 1.15618853848762 0.888888888888889 15.3 15 3 abnormal hyoid bone lesser horn morphology 0.0070287784200338 0.0354646781335377 1.15618853848762 0.888888888888889 15.3 15 3 decreased transitional stage T1 B cell number 0.0070287784200338 0.0354646781335377 1.15618853848762 0.888888888888889 15.3 15 3 abnormal hippocampus granule cell morphology 0.0070287784200338 0.0354646781335377 1.15618853848762 0.888888888888889 15.3 15 3 abnormal cerebellar layer morphology 0.0070287784200338 0.0354646781335377 1.15618853848762 0.888888888888889 15.3 15 3 abnormal telomere morphology 0.0070287784200338 0.0354646781335377 1.15618853848762 0.888888888888889 15.3 15 3 abnormal ventricle myocardium morphology 0.0070287784200338 0.0354646781335377 1.15618853848762 0.888888888888889 15.3 15 3 reduced AMPA-mediated synaptic currents 0.0070287784200338 0.0354646781335377 1.15618853848762 0.888888888888889 15.3 15 3 trigeminal neuroma 0.0070287784200338 0.0354646781335377 1.15618853848762 0.888888888888889 15.3 15 3 cerebellum atrophy 0.0070287784200338 0.0354646781335377 1.15618853848762 0.888888888888889 15.3 15 3 abnormal excitatory postsynaptic currents 1.19163855481069e-16 1.05864318038985e-14 1.15062993974489 0.884615384615385 15.3 15 3 abnormal inhibitory postsynaptic currents 1.57460599313323e-14 1.04448864211171e-12 1.14768715217521 0.882352941176471 15.3 15 3 abnormal interatrial septum morphology 0.000177990463103205 0.00180714806926213 1.14768715217521 0.882352941176471 15.3 15 3 abnormal dorsal-ventral axis patterning 0.000177990463103205 0.00180714806926213 1.14768715217521 0.882352941176471 15.3 15 3 abnormal glutamate-mediated receptor currents 0.000177990463103205 0.00180714806926213 1.14768715217521 0.882352941176471 15.3 15 3 increased brain size 0.000177990463103205 0.00180714806926213 1.14768715217521 0.882352941176471 15.3 15 3 abnormal ductus venosus valve morphology 0.000177990463103205 0.00180714806926213 1.14768715217521 0.882352941176471 15.3 15 3 decreased body fat mass 0.000177990463103205 0.00180714806926213 1.14768715217521 0.882352941176471 15.3 15 3 abnormal nest building behavior 4.99721154089301e-06 7.8179645962084e-05 1.14462665310275 0.88 15.3 15 3 increased cellular sensitivity to ionizing radiation 4.99721154089301e-06 7.8179645962084e-05 1.14462665310275 0.88 15.3 15 3 increased cochlear outer hair cell number 0.000363795886401156 0.00338296174737524 1.13812309257375 0.875 15.3 15 3 dystonia 0.000363795886401156 0.00338296174737524 1.13812309257375 0.875 15.3 15 3 abnormal ear pigmentation 0.0145192903417894 0.0642075284003576 1.13812309257375 0.875 15.3 15 3 abnormal cecum morphology 0.0145192903417894 0.0642075284003576 1.13812309257375 0.875 15.3 15 3 absent eyelids 0.0145192903417894 0.0642075284003576 1.13812309257375 0.875 15.3 15 3 short ureter 0.0145192903417894 0.0642075284003576 1.13812309257375 0.875 15.3 15 3 abnormal cellular cholesterol metabolism 0.0145192903417894 0.0642075284003576 1.13812309257375 0.875 15.3 15 3 pulmonary interstitial fibrosis 0.0145192903417894 0.0642075284003576 1.13812309257375 0.875 15.3 15 3 elevated level of mitotic sister chromatid exchange 0.0145192903417894 0.0642075284003576 1.13812309257375 0.875 15.3 15 3 abnormal forelimb zeugopod morphology 0.0145192903417894 0.0642075284003576 1.13812309257375 0.875 15.3 15 3 abnormal gastric gland morphology 0.0145192903417894 0.0642075284003576 1.13812309257375 0.875 15.3 15 3 tau protein deposits 0.0145192903417894 0.0642075284003576 1.13812309257375 0.875 15.3 15 3 abnormal extraembryonic tissue physiology 0.0145192903417894 0.0642075284003576 1.13812309257375 0.875 15.3 15 3 abnormal lateral ganglionic eminence morphology 0.0145192903417894 0.0642075284003576 1.13812309257375 0.875 15.3 15 3 thin stria vascularis 0.0145192903417894 0.0642075284003576 1.13812309257375 0.875 15.3 15 3 abnormal choroid pigmentation 0.0145192903417894 0.0642075284003576 1.13812309257375 0.875 15.3 15 3 non-pigmented tail tip 0.0145192903417894 0.0642075284003576 1.13812309257375 0.875 15.3 15 3 abnormal vertebral body development 0.0145192903417894 0.0642075284003576 1.13812309257375 0.875 15.3 15 3 abnormal olfactory bulb glomerular layer morphology 0.0145192903417894 0.0642075284003576 1.13812309257375 0.875 15.3 15 3 abnormal olfactory bulb mitral cell layer morphology 0.0145192903417894 0.0642075284003576 1.13812309257375 0.875 15.3 15 3 decreased hippocampus pyramidal cell number 0.0145192903417894 0.0642075284003576 1.13812309257375 0.875 15.3 15 3 abnormal cerebellum deep nucleus morphology 0.0145192903417894 0.0642075284003576 1.13812309257375 0.875 15.3 15 3 increased caudal vertebrae number 0.0145192903417894 0.0642075284003576 1.13812309257375 0.875 15.3 15 3 pleural effusion 0.0145192903417894 0.0642075284003576 1.13812309257375 0.875 15.3 15 3 pulmonary artery hypoplasia 0.0145192903417894 0.0642075284003576 1.13812309257375 0.875 15.3 15 3 abnormal visual evoked potential 0.0145192903417894 0.0642075284003576 1.13812309257375 0.875 15.3 15 3 abnormal anterior commissure pars posterior morphology 0.0145192903417894 0.0642075284003576 1.13812309257375 0.875 15.3 15 3 impaired neuron differentiation 0.0145192903417894 0.0642075284003576 1.13812309257375 0.875 15.3 15 3 increased cardiac stroke volume 0.0145192903417894 0.0642075284003576 1.13812309257375 0.875 15.3 15 3 abnormal umbilical vein topology 0.0145192903417894 0.0642075284003576 1.13812309257375 0.875 15.3 15 3 abnormal object recognition memory 6.04020160125266e-07 1.16023177475799e-05 1.13287828569553 0.870967741935484 15.3 15 3 abnormal postnatal growth/weight/body size 6.04020160125266e-07 1.16023177475799e-05 1.13287828569553 0.870967741935484 15.3 15 3 abnormal pup retrieval 0.000737998574871052 0.00600907186576675 1.12728382502543 0.866666666666667 15.3 15 3 abnormal placenta size 0.000737998574871052 0.00600907186576675 1.12728382502543 0.866666666666667 15.3 15 3 abnormal rostral migratory stream morphology 0.000737998574871052 0.00600907186576675 1.12728382502543 0.866666666666667 15.3 15 3 abnormal trophectoderm morphology 0.000737998574871052 0.00600907186576675 1.12728382502543 0.866666666666667 15.3 15 3 abnormal secondary palate development 0.000737998574871052 0.00600907186576675 1.12728382502543 0.866666666666667 15.3 15 3 increased myocardial infarction size 4.14642404259768e-05 0.000510825794692794 1.12334227318968 0.863636363636364 15.3 15 3 abnormal cerebral cortex pyramidal cell morphology 4.14642404259768e-05 0.000510825794692794 1.12334227318968 0.863636363636364 15.3 15 3 increased mammary gland tumor incidence 4.14642404259768e-05 0.000510825794692794 1.12334227318968 0.863636363636364 15.3 15 3 abnormal cued conditioning behavior 2.81714679653454e-10 1.03053715534995e-08 1.12218299323799 0.862745098039216 15.3 15 3 abnormal craniofacial bone morphology 3.51743666249688e-11 1.52057967457161e-09 1.11815602077421 0.859649122807018 15.3 15 3 decreased brain weight 3.51743666249688e-11 1.52057967457161e-09 1.11815602077421 0.859649122807018 15.3 15 3 reduced long term potentiation 1.8924972272824e-20 2.69004963020855e-18 1.11489609068449 0.857142857142857 15.3 15 3 abnormal liver development 2.93267782511263e-07 6.23507358116894e-06 1.11489609068449 0.857142857142857 15.3 15 3 abnormal somite shape 4.86541789714438e-06 7.73188676052728e-05 1.11489609068449 0.857142857142857 15.3 15 3 abnormal brainstem morphology 4.86541789714438e-06 7.73188676052728e-05 1.11489609068449 0.857142857142857 15.3 15 3 midline facial cleft 0.00148441775414314 0.0104900260324746 1.11489609068449 0.857142857142857 15.3 15 3 abnormal adrenal gland secretion 0.00148441775414314 0.0104900260324746 1.11489609068449 0.857142857142857 15.3 15 3 absent olfactory bulb 0.00148441775414314 0.0104900260324746 1.11489609068449 0.857142857142857 15.3 15 3 abnormal voluntary movement 0.00148441775414314 0.0104900260324746 1.11489609068449 0.857142857142857 15.3 15 3 split sternum 0.00148441775414314 0.0104900260324746 1.11489609068449 0.857142857142857 15.3 15 3 decreased CNS synapse formation 0.00148441775414314 0.0104900260324746 1.11489609068449 0.857142857142857 15.3 15 3 lysosomal protein accumulation 0.00148441775414314 0.0104900260324746 1.11489609068449 0.857142857142857 15.3 15 3 abnormal viscerocranium morphology 0.00148441775414314 0.0104900260324746 1.11489609068449 0.857142857142857 15.3 15 3 testis degeneration 0.00148441775414314 0.0104900260324746 1.11489609068449 0.857142857142857 15.3 15 3 failure of atrioventricular cushion closure 0.0296011939340263 0.107887135400572 1.11489609068449 0.857142857142857 15.3 15 3 cellular necrosis 0.0296011939340263 0.107887135400572 1.11489609068449 0.857142857142857 15.3 15 3 polyphalangy 0.0296011939340263 0.107887135400572 1.11489609068449 0.857142857142857 15.3 15 3 maxilla hypoplasia 0.0296011939340263 0.107887135400572 1.11489609068449 0.857142857142857 15.3 15 3 abnormal oculomotor nerve morphology 0.0296011939340263 0.107887135400572 1.11489609068449 0.857142857142857 15.3 15 3 decreased Schwann cell number 0.0296011939340263 0.107887135400572 1.11489609068449 0.857142857142857 15.3 15 3 retina hyperplasia 0.0296011939340263 0.107887135400572 1.11489609068449 0.857142857142857 15.3 15 3 limp posture 0.0296011939340263 0.107887135400572 1.11489609068449 0.857142857142857 15.3 15 3 abnormal tumor incidence 0.0296011939340263 0.107887135400572 1.11489609068449 0.857142857142857 15.3 15 3 abnormal gastrulation movements 0.0296011939340263 0.107887135400572 1.11489609068449 0.857142857142857 15.3 15 3 abnormal melanocyte morphology 0.0296011939340263 0.107887135400572 1.11489609068449 0.857142857142857 15.3 15 3 decreased mortality induced by ionizing radiation 0.0296011939340263 0.107887135400572 1.11489609068449 0.857142857142857 15.3 15 3 decreased cholesterol efflux 0.0296011939340263 0.107887135400572 1.11489609068449 0.857142857142857 15.3 15 3 abnormal sinus venosus morphology 0.0296011939340263 0.107887135400572 1.11489609068449 0.857142857142857 15.3 15 3 anuria 0.0296011939340263 0.107887135400572 1.11489609068449 0.857142857142857 15.3 15 3 increased cell nucleus count 0.0296011939340263 0.107887135400572 1.11489609068449 0.857142857142857 15.3 15 3 skeletal muscle interstitial fibrosis 0.0296011939340263 0.107887135400572 1.11489609068449 0.857142857142857 15.3 15 3 abnormal optic tract morphology 0.0296011939340263 0.107887135400572 1.11489609068449 0.857142857142857 15.3 15 3 abnormal organ of Corti supporting cell morphology 0.0296011939340263 0.107887135400572 1.11489609068449 0.857142857142857 15.3 15 3 absent deltoid tuberosity 0.0296011939340263 0.107887135400572 1.11489609068449 0.857142857142857 15.3 15 3 abnormal strial marginal cell morphology 0.0296011939340263 0.107887135400572 1.11489609068449 0.857142857142857 15.3 15 3 abnormal talus morphology 0.0296011939340263 0.107887135400572 1.11489609068449 0.857142857142857 15.3 15 3 increased thyroid-stimulating hormone level 0.0296011939340263 0.107887135400572 1.11489609068449 0.857142857142857 15.3 15 3 abnormal body temperature 0.0296011939340263 0.107887135400572 1.11489609068449 0.857142857142857 15.3 15 3 decreased tidal volume 0.0296011939340263 0.107887135400572 1.11489609068449 0.857142857142857 15.3 15 3 abnormal spinal cord central canal morphology 0.0296011939340263 0.107887135400572 1.11489609068449 0.857142857142857 15.3 15 3 enhanced behavioral response to alcohol 0.0296011939340263 0.107887135400572 1.11489609068449 0.857142857142857 15.3 15 3 decreased DN2 thymocyte number 0.0296011939340263 0.107887135400572 1.11489609068449 0.857142857142857 15.3 15 3 arteritis 0.0296011939340263 0.107887135400572 1.11489609068449 0.857142857142857 15.3 15 3 decreased brain cholesterol level 0.0296011939340263 0.107887135400572 1.11489609068449 0.857142857142857 15.3 15 3 long stride length 0.0296011939340263 0.107887135400572 1.11489609068449 0.857142857142857 15.3 15 3 heart block 0.0296011939340263 0.107887135400572 1.11489609068449 0.857142857142857 15.3 15 3 abnormal conotruncal ridge morphology 0.0296011939340263 0.107887135400572 1.11489609068449 0.857142857142857 15.3 15 3 altered tumor pathology 0.0296011939340263 0.107887135400572 1.11489609068449 0.857142857142857 15.3 15 3 abnormal impulsive behavior control 0.0296011939340263 0.107887135400572 1.11489609068449 0.857142857142857 15.3 15 3 small lung lobe 0.0296011939340263 0.107887135400572 1.11489609068449 0.857142857142857 15.3 15 3 parturition failure 0.0296011939340263 0.107887135400572 1.11489609068449 0.857142857142857 15.3 15 3 decreased CD8-positive, naive alpha-beta T cell number 0.0296011939340263 0.107887135400572 1.11489609068449 0.857142857142857 15.3 15 3 increased muscle cell glucose uptake 8.29520087593361e-05 0.000937923280858402 1.11489609068449 0.857142857142857 15.3 15 3 enlarged liver sinusoidal spaces 5.81449267818169e-07 1.1255681351733e-05 1.10943091376937 0.852941176470588 15.3 15 3 increased brain weight 9.65389793843645e-06 0.000140844991917071 1.10801401605064 0.851851851851852 15.3 15 3 pulmonary hypoplasia 4.36660998776235e-09 1.28543696385312e-07 1.10698902621155 0.851063829787234 15.3 15 3 head bobbing 7.03616523706749e-08 1.66690105021004e-06 1.10560528992879 0.85 15.3 15 3 abnormal CNS synaptic transmission 1.74009774676837e-17 1.79613808973431e-15 1.10363451401091 0.848484848484849 15.3 15 3 abnormal lung development 4.22546347204915e-15 3.04662040194848e-13 1.10177966608821 0.847058823529412 15.3 15 3 abnormal spatial learning 1.22776319144084e-27 3.21480098811482e-25 1.10121638405033 0.846625766871166 15.3 15 3 liver hypoplasia 1.05626236214373e-09 3.45717450767439e-08 1.10060255106033 0.846153846153846 15.3 15 3 decreased circulating glycerol level 1.90452193606319e-05 0.000261019190961828 1.10060255106033 0.846153846153846 15.3 15 3 abnormal nerve conduction 1.90452193606319e-05 0.000261019190961828 1.10060255106033 0.846153846153846 15.3 15 3 absent trabeculae carneae 0.00295687646203643 0.0184341609005404 1.10060255106033 0.846153846153846 15.3 15 3 excessive scratching 0.00295687646203643 0.0184341609005404 1.10060255106033 0.846153846153846 15.3 15 3 abnormal grip strength 0.00295687646203643 0.0184341609005404 1.10060255106033 0.846153846153846 15.3 15 3 abnormal telomere length 0.00295687646203643 0.0184341609005404 1.10060255106033 0.846153846153846 15.3 15 3 axonal dystrophy 0.00295687646203643 0.0184341609005404 1.10060255106033 0.846153846153846 15.3 15 3 muscle fatigue 0.00295687646203643 0.0184341609005404 1.10060255106033 0.846153846153846 15.3 15 3 increased cochlear inner hair cell number 0.00295687646203643 0.0184341609005404 1.10060255106033 0.846153846153846 15.3 15 3 abnormal vertebral arch development 0.00295687646203643 0.0184341609005404 1.10060255106033 0.846153846153846 15.3 15 3 abnormal embryonic neuroepithelium morphology 1.30535866886509e-10 5.03423207566186e-09 1.0988774686919 0.844827586206897 15.3 15 3 abnormal auditory brainstem response waveform shape 2.25337983426794e-06 3.8790881230045e-05 1.09747583926755 0.84375 15.3 15 3 distended abdomen 2.06625104538555e-09 6.2680481407275e-08 1.09667883430076 0.843137254901961 15.3 15 3 abnormal response to novel object 2.06625104538555e-09 6.2680481407275e-08 1.09667883430076 0.843137254901961 15.3 15 3 abnormal dendritic spine morphology 2.06625104538555e-09 6.2680481407275e-08 1.09667883430076 0.843137254901961 15.3 15 3 abnormal cell morphology 2.6053492074464e-19 3.50313846136374e-17 1.09533651014617 0.842105263157895 15.3 15 3 increased hepatocellular carcinoma incidence 2.54920432445037e-10 9.3942900104745e-09 1.09533651014617 0.842105263157895 15.3 15 3 abnormal long term depression 0.000324974990529918 0.00305623927766794 1.09533651014617 0.842105263157895 15.3 15 3 increased liver adenoma incidence 0.000324974990529918 0.00305623927766794 1.09533651014617 0.842105263157895 15.3 15 3 abnormal cochlear inner hair cell morphology 0.000324974990529918 0.00305623927766794 1.09533651014617 0.842105263157895 15.3 15 3 abnormal behavioral response to xenobiotic 0.000324974990529918 0.00305623927766794 1.09533651014617 0.842105263157895 15.3 15 3 spontaneous skin ulceration 3.73398777376688e-05 0.00047356763851562 1.0925981688708 0.84 15.3 15 3 abnormal cochlear outer hair cell morphology 3.73398777376688e-05 0.00047356763851562 1.0925981688708 0.84 15.3 15 3 enhanced long term potentiation 4.96272686988559e-10 1.72654308934831e-08 1.09166908879523 0.839285714285714 15.3 15 3 abnormal cell cycle 9.01843301945357e-19 1.15042831466106e-16 1.08581184484055 0.834782608695652 15.3 15 3 increased susceptibility to pharmacologically induced seizures 8.74589624675215e-16 6.90648155993523e-14 1.08392675483215 0.833333333333333 15.3 15 3 small liver 4.44302058736239e-13 2.37677714216429e-11 1.08392675483215 0.833333333333333 15.3 15 3 impaired limb coordination 1.862379525197e-09 5.79083633615942e-08 1.08392675483215 0.833333333333333 15.3 15 3 abnormal apoptosis 1.862379525197e-09 5.79083633615942e-08 1.08392675483215 0.833333333333333 15.3 15 3 axon degeneration 1.862379525197e-09 5.79083633615942e-08 1.08392675483215 0.833333333333333 15.3 15 3 abnormal lysosome morphology 1.02325271283367e-06 1.88644562128943e-05 1.08392675483215 0.833333333333333 15.3 15 3 abnormal malleus morphology 7.27180321982103e-05 0.000827854027885804 1.08392675483215 0.833333333333333 15.3 15 3 increased hemangiosarcoma incidence 7.27180321982103e-05 0.000827854027885804 1.08392675483215 0.833333333333333 15.3 15 3 abnormal truncus arteriosus septation 7.27180321982103e-05 0.000827854027885804 1.08392675483215 0.833333333333333 15.3 15 3 abnormal heart shape 0.00063542496276636 0.00533993106378824 1.08392675483215 0.833333333333333 15.3 15 3 abnormal mitral valve morphology 0.00063542496276636 0.00533993106378824 1.08392675483215 0.833333333333333 15.3 15 3 abnormal mammary gland morphology 0.00063542496276636 0.00533993106378824 1.08392675483215 0.833333333333333 15.3 15 3 abnormal thymus medulla morphology 0.00063542496276636 0.00533993106378824 1.08392675483215 0.833333333333333 15.3 15 3 abnormal eye anterior chamber morphology 0.00063542496276636 0.00533993106378824 1.08392675483215 0.833333333333333 15.3 15 3 increased effector memory CD8-positive, alpha-beta T cell number 0.00063542496276636 0.00533993106378824 1.08392675483215 0.833333333333333 15.3 15 3 abnormal hypoglossal nerve topology 0.00063542496276636 0.00533993106378824 1.08392675483215 0.833333333333333 15.3 15 3 abnormal supraoccipital bone morphology 0.00582424102927333 0.031426897093964 1.08392675483215 0.833333333333333 15.3 15 3 abnormal mineral level 0.00582424102927333 0.031426897093964 1.08392675483215 0.833333333333333 15.3 15 3 myocarditis 0.00582424102927333 0.031426897093964 1.08392675483215 0.833333333333333 15.3 15 3 altered tumor susceptibility 0.00582424102927333 0.031426897093964 1.08392675483215 0.833333333333333 15.3 15 3 loss of dopaminergic neurons 0.00582424102927333 0.031426897093964 1.08392675483215 0.833333333333333 15.3 15 3 increased fear-related response 0.00582424102927333 0.031426897093964 1.08392675483215 0.833333333333333 15.3 15 3 abnormal vascular endothelial cell development 0.00582424102927333 0.031426897093964 1.08392675483215 0.833333333333333 15.3 15 3 abnormal rostral-caudal body axis extension 0.00582424102927333 0.031426897093964 1.08392675483215 0.833333333333333 15.3 15 3 increased hepatocyte proliferation 0.00582424102927333 0.031426897093964 1.08392675483215 0.833333333333333 15.3 15 3 pale placenta 0.00582424102927333 0.031426897093964 1.08392675483215 0.833333333333333 15.3 15 3 abnormal amacrine cell morphology 0.00582424102927333 0.031426897093964 1.08392675483215 0.833333333333333 15.3 15 3 abnormal fatty acid level 0.00582424102927333 0.031426897093964 1.08392675483215 0.833333333333333 15.3 15 3 abnormal somatic nervous system physiology 0.00582424102927333 0.031426897093964 1.08392675483215 0.833333333333333 15.3 15 3 decreased mammary gland epithelial cell proliferation 0.00582424102927333 0.031426897093964 1.08392675483215 0.833333333333333 15.3 15 3 large anterior fontanelle 0.0593472449596843 0.181470524692335 1.08392675483215 0.833333333333333 15.3 15 3 abnormal urethra morphology 0.0593472449596843 0.181470524692335 1.08392675483215 0.833333333333333 15.3 15 3 ectopic digits 0.0593472449596843 0.181470524692335 1.08392675483215 0.833333333333333 15.3 15 3 thin tail 0.0593472449596843 0.181470524692335 1.08392675483215 0.833333333333333 15.3 15 3 epidermal necrosis 0.0593472449596843 0.181470524692335 1.08392675483215 0.833333333333333 15.3 15 3 abnormal avoidance learning behavior 0.0593472449596843 0.181470524692335 1.08392675483215 0.833333333333333 15.3 15 3 absent ectoplacental cone 0.0593472449596843 0.181470524692335 1.08392675483215 0.833333333333333 15.3 15 3 reduced NMDA-mediated synaptic currents 0.0593472449596843 0.181470524692335 1.08392675483215 0.833333333333333 15.3 15 3 abnormal parental behavior 0.0593472449596843 0.181470524692335 1.08392675483215 0.833333333333333 15.3 15 3 abnormal blood gas level 0.0593472449596843 0.181470524692335 1.08392675483215 0.833333333333333 15.3 15 3 abnormal lymph node cortex morphology 0.0593472449596843 0.181470524692335 1.08392675483215 0.833333333333333 15.3 15 3 abnormal hippocampal fimbria morphology 0.0593472449596843 0.181470524692335 1.08392675483215 0.833333333333333 15.3 15 3 liver cirrhosis 0.0593472449596843 0.181470524692335 1.08392675483215 0.833333333333333 15.3 15 3 decreased otolith number 0.0593472449596843 0.181470524692335 1.08392675483215 0.833333333333333 15.3 15 3 calcified joint 0.0593472449596843 0.181470524692335 1.08392675483215 0.833333333333333 15.3 15 3 bile duct inflammation 0.0593472449596843 0.181470524692335 1.08392675483215 0.833333333333333 15.3 15 3 abnormal intestinal peristalsis 0.0593472449596843 0.181470524692335 1.08392675483215 0.833333333333333 15.3 15 3 impaired granulosa cell differentiation 0.0593472449596843 0.181470524692335 1.08392675483215 0.833333333333333 15.3 15 3 ureter obstruction 0.0593472449596843 0.181470524692335 1.08392675483215 0.833333333333333 15.3 15 3 abnormal metopic suture morphology 0.0593472449596843 0.181470524692335 1.08392675483215 0.833333333333333 15.3 15 3 abnormal ST segment 0.0593472449596843 0.181470524692335 1.08392675483215 0.833333333333333 15.3 15 3 shortened QT interval 0.0593472449596843 0.181470524692335 1.08392675483215 0.833333333333333 15.3 15 3 abnormal heart left atrium morphology 0.0593472449596843 0.181470524692335 1.08392675483215 0.833333333333333 15.3 15 3 abnormal cholesterol level 0.0593472449596843 0.181470524692335 1.08392675483215 0.833333333333333 15.3 15 3 abnormal physical strength 0.0593472449596843 0.181470524692335 1.08392675483215 0.833333333333333 15.3 15 3 abnormal strial intermediate cell morphology 0.0593472449596843 0.181470524692335 1.08392675483215 0.833333333333333 15.3 15 3 decreased cochlear microphonics 0.0593472449596843 0.181470524692335 1.08392675483215 0.833333333333333 15.3 15 3 absent parietal bone 0.0593472449596843 0.181470524692335 1.08392675483215 0.833333333333333 15.3 15 3 decreased prostate gland weight 0.0593472449596843 0.181470524692335 1.08392675483215 0.833333333333333 15.3 15 3 abnormal blastocoele morphology 0.0593472449596843 0.181470524692335 1.08392675483215 0.833333333333333 15.3 15 3 abnormal ligament morphology 0.0593472449596843 0.181470524692335 1.08392675483215 0.833333333333333 15.3 15 3 abnormal pulmonary respiratory rate 0.0593472449596843 0.181470524692335 1.08392675483215 0.833333333333333 15.3 15 3 abnormal dermis papillary layer morphology 0.0593472449596843 0.181470524692335 1.08392675483215 0.833333333333333 15.3 15 3 abnormal eyelid development 0.0593472449596843 0.181470524692335 1.08392675483215 0.833333333333333 15.3 15 3 delayed chorioallantoic fusion 0.0593472449596843 0.181470524692335 1.08392675483215 0.833333333333333 15.3 15 3 abnormal aorta tunica adventitia morphology 0.0593472449596843 0.181470524692335 1.08392675483215 0.833333333333333 15.3 15 3 increased transitional stage T1 B cell number 0.0593472449596843 0.181470524692335 1.08392675483215 0.833333333333333 15.3 15 3 abnormal orbit morphology 0.0593472449596843 0.181470524692335 1.08392675483215 0.833333333333333 15.3 15 3 abnormal oval cell physiology 0.0593472449596843 0.181470524692335 1.08392675483215 0.833333333333333 15.3 15 3 myocardium hypoplasia 0.0593472449596843 0.181470524692335 1.08392675483215 0.833333333333333 15.3 15 3 common truncal valve 0.0593472449596843 0.181470524692335 1.08392675483215 0.833333333333333 15.3 15 3 abnormal intestinal enteroendocrine cell morphology 0.0593472449596843 0.181470524692335 1.08392675483215 0.833333333333333 15.3 15 3 abnormal ureteric bud elongation 0.0593472449596843 0.181470524692335 1.08392675483215 0.833333333333333 15.3 15 3 abnormal ureteric bud tip morphology 0.0593472449596843 0.181470524692335 1.08392675483215 0.833333333333333 15.3 15 3 absent midbrain 0.0593472449596843 0.181470524692335 1.08392675483215 0.833333333333333 15.3 15 3 thymus cortex atrophy 0.0593472449596843 0.181470524692335 1.08392675483215 0.833333333333333 15.3 15 3 absent thymus corticomedullary boundary 0.0593472449596843 0.181470524692335 1.08392675483215 0.833333333333333 15.3 15 3 additional anastomosis between intracranial vertebral arteries 0.0593472449596843 0.181470524692335 1.08392675483215 0.833333333333333 15.3 15 3 abnormal platelet alpha-granule morphology 0.0593472449596843 0.181470524692335 1.08392675483215 0.833333333333333 15.3 15 3 increased body fat mass 0.0593472449596843 0.181470524692335 1.08392675483215 0.833333333333333 15.3 15 3 decreased tear production 0.0593472449596843 0.181470524692335 1.08392675483215 0.833333333333333 15.3 15 3 abnormal inhibitory learning 0.0593472449596843 0.181470524692335 1.08392675483215 0.833333333333333 15.3 15 3 abnormal excitatory synapse morphology 0.0593472449596843 0.181470524692335 1.08392675483215 0.833333333333333 15.3 15 3 decreased retinal apoptosis 0.0593472449596843 0.181470524692335 1.08392675483215 0.833333333333333 15.3 15 3 thick ventricular wall 2.38991294652728e-07 5.21483197761984e-06 1.0786393072476 0.829268292682927 15.3 15 3 decreased bone mineralization 1.97432644680154e-06 3.4223951473302e-05 1.07773288766168 0.828571428571429 15.3 15 3 cochlear ganglion degeneration 8.51966347125984e-10 2.84465273620924e-08 1.07645139790227 0.827586206896552 15.3 15 3 abnormal middle ear morphology 1.65121495982374e-05 0.000228188734031198 1.07645139790227 0.827586206896552 15.3 15 3 abnormal placenta vasculature 6.89175253198539e-09 1.93708863540267e-07 1.07558885671805 0.826923076923077 15.3 15 3 abnormal basicranium morphology 0.000140586622685124 0.00150089795677788 1.07450130479013 0.826086956521739 15.3 15 3 abnormal axon morphology 8.66422981569599e-17 7.83718969692501e-15 1.0718831242229 0.824074074074074 15.3 15 3 abnormal nervous system development 3.7889377230568e-06 6.28332172406919e-05 1.07117467536353 0.823529411764706 15.3 15 3 abnormal touch/ nociception 0.00123088786179159 0.00925025243566941 1.07117467536353 0.823529411764706 15.3 15 3 abnormal involuntary movement 0.00123088786179159 0.00925025243566941 1.07117467536353 0.823529411764706 15.3 15 3 abnormal embryonic-extraembryonic boundary morphology 0.00123088786179159 0.00925025243566941 1.07117467536353 0.823529411764706 15.3 15 3 abnormal tarsal bone morphology 0.00123088786179159 0.00925025243566941 1.07117467536353 0.823529411764706 15.3 15 3 decreased growth hormone level 0.00123088786179159 0.00925025243566941 1.07117467536353 0.823529411764706 15.3 15 3 coloboma 0.00123088786179159 0.00925025243566941 1.07117467536353 0.823529411764706 15.3 15 3 increased trabecular bone mass 0.00123088786179159 0.00925025243566941 1.07117467536353 0.823529411764706 15.3 15 3 lethality at weaning, complete penetrance 1.07128243798651e-07 2.49048136868358e-06 1.06947439810105 0.822222222222222 15.3 15 3 shortened head 3.168090612838e-05 0.000409383137632962 1.06844208690597 0.821428571428571 15.3 15 3 lymphoid hyperplasia 3.168090612838e-05 0.000409383137632962 1.06844208690597 0.821428571428571 15.3 15 3 increased startle reflex 8.22615387792828e-14 4.99086774910893e-12 1.06687622161007 0.820224719101124 15.3 15 3 abnormal axon extension 2.51192361897024e-08 6.34356345399844e-07 1.06658392675483 0.82 15.3 15 3 abnormal maternal nurturing 7.35340459350135e-10 2.50569779812803e-08 1.06615746376932 0.819672131147541 15.3 15 3 abnormal erythropoiesis 5.957330634618e-16 4.78027740439106e-14 1.06534515332074 0.819047619047619 15.3 15 3 abnormal head morphology 5.9095886676508e-09 1.69943373535045e-07 1.06421899565338 0.818181818181818 15.3 15 3 lethality, incomplete penetrance 2.03881432910882e-07 4.5484759135948e-06 1.06421899565338 0.818181818181818 15.3 15 3 intracerebral hemorrhage 0.000269646966259453 0.0026149973823407 1.06421899565338 0.818181818181818 15.3 15 3 failure of palatal shelf elevation 0.000269646966259453 0.0026149973823407 1.06421899565338 0.818181818181818 15.3 15 3 enlarged cranium 0.0113231364330542 0.0526965423334375 1.06421899565338 0.818181818181818 15.3 15 3 delayed hepatic development 0.0113231364330542 0.0526965423334375 1.06421899565338 0.818181818181818 15.3 15 3 abnormal eye distance/ position 0.0113231364330542 0.0526965423334375 1.06421899565338 0.818181818181818 15.3 15 3 social withdrawal 0.0113231364330542 0.0526965423334375 1.06421899565338 0.818181818181818 15.3 15 3 failure of somite differentiation 0.0113231364330542 0.0526965423334375 1.06421899565338 0.818181818181818 15.3 15 3 abnormal proximal-distal axis patterning 0.0113231364330542 0.0526965423334375 1.06421899565338 0.818181818181818 15.3 15 3 fatigue 0.0113231364330542 0.0526965423334375 1.06421899565338 0.818181818181818 15.3 15 3 fused joints 0.0113231364330542 0.0526965423334375 1.06421899565338 0.818181818181818 15.3 15 3 pulmonary hypertension 0.0113231364330542 0.0526965423334375 1.06421899565338 0.818181818181818 15.3 15 3 increased glycogen level 0.0113231364330542 0.0526965423334375 1.06421899565338 0.818181818181818 15.3 15 3 common atrioventricular valve 0.0113231364330542 0.0526965423334375 1.06421899565338 0.818181818181818 15.3 15 3 decreased embryonic cilium length 0.0113231364330542 0.0526965423334375 1.06421899565338 0.818181818181818 15.3 15 3 thin hypoglossal nerve 0.0113231364330542 0.0526965423334375 1.06421899565338 0.818181818181818 15.3 15 3 decreased cell proliferation 1.25365375244877e-26 2.71170757323158e-24 1.06166231338154 0.816216216216216 15.3 15 3 impaired branching involved in ureteric bud morphogenesis 1.66519258216477e-06 2.9586903915249e-05 1.0611072442041 0.815789473684211 15.3 15 3 abnormal craniofacial morphology 2.13211562679721e-15 1.58317540945016e-13 1.06077492123379 0.815533980582524 15.3 15 3 abnormal chondrocyte morphology 1.11868454564202e-08 2.94468551035398e-07 1.05983949361365 0.814814814814815 15.3 15 3 decreased bone ossification 6.03670336182921e-05 0.000708316019459913 1.05983949361365 0.814814814814815 15.3 15 3 embryonic lethality between somite formation and embryo turning, complete penetrance 7.81052324428607e-11 3.13365751131639e-09 1.05915128615027 0.814285714285714 15.3 15 3 abnormal embryo size 1.22142727491353e-16 1.06607029696401e-14 1.05898684719884 0.814159292035398 15.3 15 3 abnormal posture 4.40520476852777e-12 2.08722797365958e-10 1.05682858596134 0.8125 15.3 15 3 vertebral transformation 9.00608330611882e-08 2.1134558701859e-06 1.05682858596134 0.8125 15.3 15 3 kidney cortex cysts 1.37124272847783e-05 0.000194357053395362 1.05682858596134 0.8125 15.3 15 3 abnormal long term potentiation 1.37124272847783e-05 0.000194357053395362 1.05682858596134 0.8125 15.3 15 3 abnormal tympanic ring morphology 0.00235954355824061 0.0155069077968917 1.05682858596134 0.8125 15.3 15 3 abnormal hair follicle orientation 0.00235954355824061 0.0155069077968917 1.05682858596134 0.8125 15.3 15 3 intraventricular hemorrhage 0.00235954355824061 0.0155069077968917 1.05682858596134 0.8125 15.3 15 3 white spotting 0.00235954355824061 0.0155069077968917 1.05682858596134 0.8125 15.3 15 3 decreased aggression towards mice 0.00235954355824061 0.0155069077968917 1.05682858596134 0.8125 15.3 15 3 abnormal amnion morphology 0.00235954355824061 0.0155069077968917 1.05682858596134 0.8125 15.3 15 3 blepharitis 0.00235954355824061 0.0155069077968917 1.05682858596134 0.8125 15.3 15 3 decreased liver cholesterol level 0.00235954355824061 0.0155069077968917 1.05682858596134 0.8125 15.3 15 3 abnormal anxiety-related response 0.000512712950104153 0.00456822946358751 1.0529574189798 0.80952380952381 15.3 15 3 embryonic lethality at implantation, complete penetrance 0.000512712950104153 0.00456822946358751 1.0529574189798 0.80952380952381 15.3 15 3 abnormal neuron morphology 2.66045877489223e-14 1.71893277988167e-12 1.0510804895342 0.808080808080808 15.3 15 3 abnormal ureter morphology 0.000114177442921224 0.00124005092449087 1.05057516237577 0.807692307692308 15.3 15 3 thick skin 0.000114177442921224 0.00124005092449087 1.05057516237577 0.807692307692308 15.3 15 3 seizures 3.62162852251023e-16 3.00293364991474e-14 1.04969748889008 0.807017543859649 15.3 15 3 hydrops fetalis 1.22233505384938e-10 4.75087257257863e-09 1.04779586300441 0.805555555555556 15.3 15 3 abnormal pharyngeal arch morphology 5.91448905895421e-06 9.10977803972049e-05 1.04779586300441 0.805555555555556 15.3 15 3 abnormal cell death 3.17161399832153e-07 6.62973934523094e-06 1.04622495466407 0.804347826086957 15.3 15 3 failure to gastrulate 3.17161399832153e-07 6.62973934523094e-06 1.04622495466407 0.804347826086957 15.3 15 3 increased neuron apoptosis 1.28033950592535e-11 5.89786022405425e-10 1.04378131946799 0.802469135802469 15.3 15 3 abnormal nervous system physiology 1.03623595954164e-15 7.93119061341489e-14 1.04056968463886 0.8 15.3 15 3 increased B cell derived lymphoma incidence 1.37849676381789e-07 3.14588137614404e-06 1.04056968463886 0.8 15.3 15 3 increased liver glycogen level 0.000214230650040375 0.00215748478532564 1.04056968463886 0.8 15.3 15 3 abnormal action potential 4.23063209656012e-10 1.50338533431333e-08 1.04056968463886 0.8 15.3 15 3 impaired behavioral response to xenobiotic 1.10473828280778e-05 0.000158846039218748 1.04056968463886 0.8 15.3 15 3 anencephaly 0.000965630009920955 0.00751801142309351 1.04056968463886 0.8 15.3 15 3 abnormal hearing physiology 0.000965630009920955 0.00751801142309351 1.04056968463886 0.8 15.3 15 3 spleen atrophy 0.000965630009920955 0.00751801142309351 1.04056968463886 0.8 15.3 15 3 abnormal incus morphology 0.000965630009920955 0.00751801142309351 1.04056968463886 0.8 15.3 15 3 abnormal enteric neuron morphology 0.00447009447123148 0.0251854133571649 1.04056968463886 0.8 15.3 15 3 hyperpigmentation 0.00447009447123148 0.0251854133571649 1.04056968463886 0.8 15.3 15 3 abnormal apical ectodermal ridge morphology 0.00447009447123148 0.0251854133571649 1.04056968463886 0.8 15.3 15 3 abnormal bronchus morphology 0.00447009447123148 0.0251854133571649 1.04056968463886 0.8 15.3 15 3 increased alcohol consumption 0.00447009447123148 0.0251854133571649 1.04056968463886 0.8 15.3 15 3 decreased aggression towards males 0.00447009447123148 0.0251854133571649 1.04056968463886 0.8 15.3 15 3 abnormal olfactory nerve morphology 0.00447009447123148 0.0251854133571649 1.04056968463886 0.8 15.3 15 3 abnormal cerebral aqueduct morphology 0.00447009447123148 0.0251854133571649 1.04056968463886 0.8 15.3 15 3 abnormal branching involved in lung morphogenesis 0.00447009447123148 0.0251854133571649 1.04056968463886 0.8 15.3 15 3 heterochrony 0.00447009447123148 0.0251854133571649 1.04056968463886 0.8 15.3 15 3 absent maxillary shelf 0.0216765225203655 0.0850478702987528 1.04056968463886 0.8 15.3 15 3 absent palatine bone horizontal plate 0.0216765225203655 0.0850478702987528 1.04056968463886 0.8 15.3 15 3 increased cranium width 0.0216765225203655 0.0850478702987528 1.04056968463886 0.8 15.3 15 3 abnormal grooming behavior 0.0216765225203655 0.0850478702987528 1.04056968463886 0.8 15.3 15 3 rhinitis 0.0216765225203655 0.0850478702987528 1.04056968463886 0.8 15.3 15 3 abnormal mammary gland physiology 0.0216765225203655 0.0850478702987528 1.04056968463886 0.8 15.3 15 3 decreased incidence of induced tumors 0.0216765225203655 0.0850478702987528 1.04056968463886 0.8 15.3 15 3 abnormal PNS synaptic transmission 0.0216765225203655 0.0850478702987528 1.04056968463886 0.8 15.3 15 3 acrania 0.0216765225203655 0.0850478702987528 1.04056968463886 0.8 15.3 15 3 peritoneal inflammation 0.0216765225203655 0.0850478702987528 1.04056968463886 0.8 15.3 15 3 abnormal glial cell physiology 0.0216765225203655 0.0850478702987528 1.04056968463886 0.8 15.3 15 3 abnormal pillar cell morphology 0.0216765225203655 0.0850478702987528 1.04056968463886 0.8 15.3 15 3 abnormal ear physiology 0.0216765225203655 0.0850478702987528 1.04056968463886 0.8 15.3 15 3 abnormal deltoid tuberosity morphology 0.0216765225203655 0.0850478702987528 1.04056968463886 0.8 15.3 15 3 abnormal corneal endothelium morphology 0.0216765225203655 0.0850478702987528 1.04056968463886 0.8 15.3 15 3 abnormal gonadal fat pad morphology 0.0216765225203655 0.0850478702987528 1.04056968463886 0.8 15.3 15 3 vascular smooth muscle hyperplasia 0.0216765225203655 0.0850478702987528 1.04056968463886 0.8 15.3 15 3 protruding tongue 0.0216765225203655 0.0850478702987528 1.04056968463886 0.8 15.3 15 3 decreased transitional stage T2 B cell number 0.0216765225203655 0.0850478702987528 1.04056968463886 0.8 15.3 15 3 abnormal cerebellar granule cell migration 0.0216765225203655 0.0850478702987528 1.04056968463886 0.8 15.3 15 3 increased serotonin level 0.0216765225203655 0.0850478702987528 1.04056968463886 0.8 15.3 15 3 umbilical hernia 0.0216765225203655 0.0850478702987528 1.04056968463886 0.8 15.3 15 3 increased T-helper 17 cell number 0.0216765225203655 0.0850478702987528 1.04056968463886 0.8 15.3 15 3 abnormal inferior vena cava valve morphology 0.0216765225203655 0.0850478702987528 1.04056968463886 0.8 15.3 15 3 thick aortic valve cusps 0.0216765225203655 0.0850478702987528 1.04056968463886 0.8 15.3 15 3 thick aortic valve 0.0216765225203655 0.0850478702987528 1.04056968463886 0.8 15.3 15 3 sinus bradycardia 0.0216765225203655 0.0850478702987528 1.04056968463886 0.8 15.3 15 3 decreased macrophage apoptosis 0.0216765225203655 0.0850478702987528 1.04056968463886 0.8 15.3 15 3 decreased circulating lactate level 0.0216765225203655 0.0850478702987528 1.04056968463886 0.8 15.3 15 3 hyperactivity 5.5763968599726e-47 3.08250826426263e-44 1.0377649145994 0.797843665768194 15.3 15 3 abnormal placenta morphology 4.39807826272745e-11 1.83869238294698e-09 1.03727674259886 0.79746835443038 15.3 15 3 kidney cysts 1.85422274236611e-10 7.04180010936746e-09 1.03705424651508 0.797297297297297 15.3 15 3 decreased anxiety-related response 2.0227957729627e-16 1.70566253737109e-14 1.03633972657122 0.796747967479675 15.3 15 3 abnormal neuronal precursor proliferation 5.98171508395289e-08 1.45877610503263e-06 1.03575223239516 0.796296296296296 15.3 15 3 abnormal craniofacial development 2.5540331751015e-07 5.54860919044977e-06 1.0352606556356 0.795918367346939 15.3 15 3 impaired balance 1.14328112105018e-13 6.85279949063212e-12 1.03291843695769 0.794117647058823 15.3 15 3 gliosis 6.112226158838e-09 1.74760489311604e-07 1.03231119507823 0.793650793650794 15.3 15 3 abnormal locomotor behavior 2.00975231615424e-12 9.89952254739341e-11 1.03208677960104 0.793478260869565 15.3 15 3 lordosis 8.9827806160593e-05 0.000997529767073549 1.03159925632301 0.793103448275862 15.3 15 3 abnormal outer ear morphology 8.9827806160593e-05 0.000997529767073549 1.03159925632301 0.793103448275862 15.3 15 3 abnormal hepatocyte morphology 1.1987635045568e-14 8.16965539064395e-13 1.03119518297545 0.792792792792793 15.3 15 3 enlarged kidney 1.10301008787501e-07 2.55231404054798e-06 1.03075298950076 0.792452830188679 15.3 15 3 abnormal neuromuscular synapse morphology 6.2885641672463e-10 2.15762805048623e-08 1.02973041709054 0.791666666666667 15.3 15 3 small heart 4.70909544776226e-07 9.37109994104689e-06 1.02973041709054 0.791666666666667 15.3 15 3 curly tail 4.70909544776226e-07 9.37109994104689e-06 1.02973041709054 0.791666666666667 15.3 15 3 abnormal startle reflex 0.000398487266535395 0.00364561772530396 1.02973041709054 0.791666666666667 15.3 15 3 abnormal tumor morphology 0.000398487266535395 0.00364561772530396 1.02973041709054 0.791666666666667 15.3 15 3 limb grasping 6.68159792077708e-23 1.07228869857632e-20 1.02913485293953 0.791208791208791 15.3 15 3 embryonic lethality, complete penetrance 8.41571116244144e-39 3.48901358609551e-36 1.02752178890671 0.789968652037618 15.3 15 3 lethality throughout fetal growth and development, complete penetrance 1.28900816145944e-23 2.1376052010869e-21 1.02687797826203 0.789473684210526 15.3 15 3 increased grooming behavior 8.70516351416675e-06 0.000129665234978981 1.02687797826203 0.789473684210526 15.3 15 3 kyphoscoliosis 0.00179961235865301 0.0122781341689733 1.02687797826203 0.789473684210526 15.3 15 3 stereotypic behavior 0.00179961235865301 0.0122781341689733 1.02687797826203 0.789473684210526 15.3 15 3 decreased chemically-elicited antinociception 0.00179961235865301 0.0122781341689733 1.02687797826203 0.789473684210526 15.3 15 3 increased malignant tumor incidence 0.00179961235865301 0.0122781341689733 1.02687797826203 0.789473684210526 15.3 15 3 abnormal metatarsal bone morphology 0.00179961235865301 0.0122781341689733 1.02687797826203 0.789473684210526 15.3 15 3 abnormal response to novelty 0.00179961235865301 0.0122781341689733 1.02687797826203 0.789473684210526 15.3 15 3 abnormal blastocyst morphology 0.00179961235865301 0.0122781341689733 1.02687797826203 0.789473684210526 15.3 15 3 increased bone mineral content 4.02201756381894e-14 2.5011921724999e-12 1.02624991833649 0.788990825688073 15.3 15 3 pallor 9.32322756967044e-22 1.40554718663971e-19 1.02570440342973 0.788571428571429 15.3 15 3 increased cardiomyocyte apoptosis 3.77902216061711e-05 0.00047356763851562 1.02480347729585 0.787878787878788 15.3 15 3 single kidney 3.77902216061711e-05 0.00047356763851562 1.02480347729585 0.787878787878788 15.3 15 3 abnormal middle ear ossicle morphology 3.77902216061711e-05 0.00047356763851562 1.02480347729585 0.787878787878788 15.3 15 3 ataxia 1.0862370472571e-24 2.07847281157849e-22 1.02382784565333 0.787128712871287 15.3 15 3 abnormal jaw morphology 0.000165549501081303 0.0017266431192442 1.02198808312745 0.785714285714286 15.3 15 3 abnormal ovulation 0.000165549501081303 0.0017266431192442 1.02198808312745 0.785714285714286 15.3 15 3 absent corpus callosum 0.000165549501081303 0.0017266431192442 1.02198808312745 0.785714285714286 15.3 15 3 abnormal interparietal bone morphology 0.00835589172431184 0.0407155350915293 1.02198808312745 0.785714285714286 15.3 15 3 increased aggression towards males 0.00835589172431184 0.0407155350915293 1.02198808312745 0.785714285714286 15.3 15 3 abnormal placing response 0.00835589172431184 0.0407155350915293 1.02198808312745 0.785714285714286 15.3 15 3 abnormal endplate potential 0.00835589172431184 0.0407155350915293 1.02198808312745 0.785714285714286 15.3 15 3 intestinal obstruction 0.00835589172431184 0.0407155350915293 1.02198808312745 0.785714285714286 15.3 15 3 amyloid beta deposits 0.00835589172431184 0.0407155350915293 1.02198808312745 0.785714285714286 15.3 15 3 failure of zygotic cell division 0.00835589172431184 0.0407155350915293 1.02198808312745 0.785714285714286 15.3 15 3 abnormal imprinting 0.00835589172431184 0.0407155350915293 1.02198808312745 0.785714285714286 15.3 15 3 skeletal muscle necrosis 0.00835589172431184 0.0407155350915293 1.02198808312745 0.785714285714286 15.3 15 3 abnormal squamosal bone morphology 0.00835589172431184 0.0407155350915293 1.02198808312745 0.785714285714286 15.3 15 3 spina bifida occulta 0.00835589172431184 0.0407155350915293 1.02198808312745 0.785714285714286 15.3 15 3 decreased compact bone area 0.00835589172431184 0.0407155350915293 1.02198808312745 0.785714285714286 15.3 15 3 multiple persisting craniopharyngeal ducts 0.00835589172431184 0.0407155350915293 1.02198808312745 0.785714285714286 15.3 15 3 abnormal cartilage morphology 3.70166918552901e-06 6.17980006644523e-05 1.02198808312745 0.785714285714286 15.3 15 3 small lung 3.6982483652522e-07 7.66616067380404e-06 1.02016635748908 0.784313725490196 15.3 15 3 abnormal suckling behavior 2.24269066481354e-11 1.01430782340431e-09 1.01987653750116 0.784090909090909 15.3 15 3 embryonic lethality before implantation, complete penetrance 1.46163091310822e-15 1.10175966556264e-13 1.01975829094608 0.784 15.3 15 3 abnormal neural tube closure 9.39054892087601e-11 3.70777626042525e-09 1.01862996237238 0.783132530120482 15.3 15 3 embryonic lethality between implantation and placentation, complete penetrance 1.57633223165937e-06 2.81084331631016e-05 1.01794860453802 0.782608695652174 15.3 15 3 abnormal chondrocyte physiology 0.000734264203127039 0.00600907186576675 1.01794860453802 0.782608695652174 15.3 15 3 abnormal learning/memory/conditioning 1.58435064489975e-07 3.58686278119656e-06 1.01692037362434 0.781818181818182 15.3 15 3 abnormal vertebral body morphology 6.91502401340068e-05 0.00079450911008472 1.01618133265514 0.78125 15.3 15 3 neonatal lethality 6.91502401340068e-05 0.00079450911008472 1.01618133265514 0.78125 15.3 15 3 abnormal depression-related behavior 6.91502401340068e-05 0.00079450911008472 1.01618133265514 0.78125 15.3 15 3 abnormal spongiotrophoblast layer morphology 6.91502401340068e-05 0.00079450911008472 1.01618133265514 0.78125 15.3 15 3 abnormal mammary gland development 6.74590795325471e-06 0.000102632697453952 1.01518993623303 0.780487804878049 15.3 15 3 palatal shelves fail to meet at midline 6.74590795325471e-06 0.000102632697453952 1.01518993623303 0.780487804878049 15.3 15 3 pericardial edema 6.93081729282216e-09 1.93712449616799e-07 1.01379031775477 0.779411764705882 15.3 15 3 cleft palate 9.06947475824531e-16 7.05009951910476e-14 1.01276820451492 0.778625954198473 15.3 15 3 heart right ventricle hypertrophy 2.90125110200101e-05 0.000380031877620454 1.01166497117667 0.777777777777778 15.3 15 3 abnormal trophoblast giant cell morphology 2.90125110200101e-05 0.000380031877620454 1.01166497117667 0.777777777777778 15.3 15 3 abnormal type II pneumocyte morphology 0.000302513875481487 0.00289424332792384 1.01166497117667 0.777777777777778 15.3 15 3 abnormal eye muscle morphology 0.000302513875481487 0.00289424332792384 1.01166497117667 0.777777777777778 15.3 15 3 lowered ear position 0.00331500800837989 0.0199881156502155 1.01166497117667 0.777777777777778 15.3 15 3 delayed kidney development 0.00331500800837989 0.0199881156502155 1.01166497117667 0.777777777777778 15.3 15 3 absent ureter 0.00331500800837989 0.0199881156502155 1.01166497117667 0.777777777777778 15.3 15 3 decreased lactate dehydrogenase level 0.00331500800837989 0.0199881156502155 1.01166497117667 0.777777777777778 15.3 15 3 decreased pulmonary respiratory rate 0.00331500800837989 0.0199881156502155 1.01166497117667 0.777777777777778 15.3 15 3 atrioventricular block 0.00331500800837989 0.0199881156502155 1.01166497117667 0.777777777777778 15.3 15 3 abnormal head movements 0.0407360820679339 0.133858658050179 1.01166497117667 0.777777777777778 15.3 15 3 crypts of Lieberkuhn abscesses 0.0407360820679339 0.133858658050179 1.01166497117667 0.777777777777778 15.3 15 3 abnormal geniculate ganglion morphology 0.0407360820679339 0.133858658050179 1.01166497117667 0.777777777777778 15.3 15 3 abnormal kindling response 0.0407360820679339 0.133858658050179 1.01166497117667 0.777777777777778 15.3 15 3 abnormal germ cell morphology 0.0407360820679339 0.133858658050179 1.01166497117667 0.777777777777778 15.3 15 3 abnormal vomeronasal organ morphology 0.0407360820679339 0.133858658050179 1.01166497117667 0.777777777777778 15.3 15 3 decreased circulating bicarbonate level 0.0407360820679339 0.133858658050179 1.01166497117667 0.777777777777778 15.3 15 3 enlarged otoliths 0.0407360820679339 0.133858658050179 1.01166497117667 0.777777777777778 15.3 15 3 premature bone ossification 0.0407360820679339 0.133858658050179 1.01166497117667 0.777777777777778 15.3 15 3 abnormal ovary physiology 0.0407360820679339 0.133858658050179 1.01166497117667 0.777777777777778 15.3 15 3 small scapula 0.0407360820679339 0.133858658050179 1.01166497117667 0.777777777777778 15.3 15 3 decreased cochlear hair cell number 0.0407360820679339 0.133858658050179 1.01166497117667 0.777777777777778 15.3 15 3 abnormal gallbladder physiology 0.0407360820679339 0.133858658050179 1.01166497117667 0.777777777777778 15.3 15 3 decreased thyroid-stimulating hormone level 0.0407360820679339 0.133858658050179 1.01166497117667 0.777777777777778 15.3 15 3 hemothorax 0.0407360820679339 0.133858658050179 1.01166497117667 0.777777777777778 15.3 15 3 enhanced conditioned place preference behavior 0.0407360820679339 0.133858658050179 1.01166497117667 0.777777777777778 15.3 15 3 abnormal retinal development 0.0407360820679339 0.133858658050179 1.01166497117667 0.777777777777778 15.3 15 3 eye opacity 0.0407360820679339 0.133858658050179 1.01166497117667 0.777777777777778 15.3 15 3 retropulsion 0.0407360820679339 0.133858658050179 1.01166497117667 0.777777777777778 15.3 15 3 shortened ST segment 0.0407360820679339 0.133858658050179 1.01166497117667 0.777777777777778 15.3 15 3 decreased effector memory CD4-positive, alpha-beta T cell number 0.0407360820679339 0.133858658050179 1.01166497117667 0.777777777777778 15.3 15 3 abnormal ureteric bud invasion 0.0407360820679339 0.133858658050179 1.01166497117667 0.777777777777778 15.3 15 3 decreased bone trabecular spacing 0.0407360820679339 0.133858658050179 1.01166497117667 0.777777777777778 15.3 15 3 abnormal infrahyoid muscle connection 0.0407360820679339 0.133858658050179 1.01166497117667 0.777777777777778 15.3 15 3 decreased platelet dense granule number 0.0407360820679339 0.133858658050179 1.01166497117667 0.777777777777778 15.3 15 3 abnormal social investigation 5.53421682081569e-10 1.91199504746931e-08 1.0080518819939 0.775 15.3 15 3 abnormal eyelid morphology 0.000125556360002382 0.00135204088963604 1.00700292061825 0.774193548387097 15.3 15 3 decreased exploration in new environment 2.38463475687751e-10 8.98754387535274e-09 1.00650341520128 0.773809523809524 15.3 15 3 abnormal behavior 6.93577535525598e-31 2.15659264952491e-28 1.00594641275789 0.773381294964029 15.3 15 3 abnormal astrocyte morphology 5.16065375976231e-06 7.99820948748209e-05 1.00509571811708 0.772727272727273 15.3 15 3 muscular atrophy 5.16065375976231e-06 7.99820948748209e-05 1.00509571811708 0.772727272727273 15.3 15 3 omphalocele 5.16065375976231e-06 7.99820948748209e-05 1.00509571811708 0.772727272727273 15.3 15 3 abnormal basisphenoid bone morphology 0.00133913729517613 0.00966938758127902 1.00509571811708 0.772727272727273 15.3 15 3 abnormal long bone epiphysis morphology 0.00133913729517613 0.00966938758127902 1.00509571811708 0.772727272727273 15.3 15 3 abnormal tail movements 0.00133913729517613 0.00966938758127902 1.00509571811708 0.772727272727273 15.3 15 3 aphakia 0.00133913729517613 0.00966938758127902 1.00509571811708 0.772727272727273 15.3 15 3 abnormal lysosome physiology 0.00133913729517613 0.00966938758127902 1.00509571811708 0.772727272727273 15.3 15 3 abnormal cochlear sensory epithelium morphology 0.00133913729517613 0.00966938758127902 1.00509571811708 0.772727272727273 15.3 15 3 prolonged PR interval 0.00133913729517613 0.00966938758127902 1.00509571811708 0.772727272727273 15.3 15 3 increased adenoma incidence 0.00133913729517613 0.00966938758127902 1.00509571811708 0.772727272727273 15.3 15 3 incomplete embryo turning 2.20536184448432e-07 4.87630007835977e-06 1.00405846763399 0.771929824561403 15.3 15 3 abnormal facial morphology 2.20536184448432e-07 4.87630007835977e-06 1.00405846763399 0.771929824561403 15.3 15 3 increased carcinoma incidence 5.24130730914558e-05 0.000622327061169434 1.00340648161604 0.771428571428571 15.3 15 3 abnormal midbrain development 5.24130730914558e-05 0.000622327061169434 1.00340648161604 0.771428571428571 15.3 15 3 abnormal hippocampus pyramidal cell morphology 5.24130730914558e-05 0.000622327061169434 1.00340648161604 0.771428571428571 15.3 15 3 lethality throughout fetal growth and development, incomplete penetrance 4.05001694527718e-20 5.59689841743166e-18 1.00278363463801 0.770949720670391 15.3 15 3 short limbs 1.83829414692764e-10 7.03501029305e-09 1.0016978286035 0.770114942528736 15.3 15 3 ventricular hypoplasia 0.000547741340437543 0.00475888402958333 1.00054777369121 0.769230769230769 15.3 15 3 abnormal Mullerian duct morphology 0.000547741340437543 0.00475888402958333 1.00054777369121 0.769230769230769 15.3 15 3 increased thymocyte apoptosis 0.000547741340437543 0.00475888402958333 1.00054777369121 0.769230769230769 15.3 15 3 short premaxilla 0.015382122920063 0.0649926786499296 1.00054777369121 0.769230769230769 15.3 15 3 short hair 0.015382122920063 0.0649926786499296 1.00054777369121 0.769230769230769 15.3 15 3 increased foot pad pigmentation 0.015382122920063 0.0649926786499296 1.00054777369121 0.769230769230769 15.3 15 3 abnormal pulmonary alveolus epithelial cell morphology 0.015382122920063 0.0649926786499296 1.00054777369121 0.769230769230769 15.3 15 3 abnormal coping response 0.015382122920063 0.0649926786499296 1.00054777369121 0.769230769230769 15.3 15 3 abnormal GABAergic neuron morphology 0.015382122920063 0.0649926786499296 1.00054777369121 0.769230769230769 15.3 15 3 abnormal afterhyperpolarization 0.015382122920063 0.0649926786499296 1.00054777369121 0.769230769230769 15.3 15 3 abnormal insulin secretion 0.015382122920063 0.0649926786499296 1.00054777369121 0.769230769230769 15.3 15 3 vestibular hair cell degeneration 0.015382122920063 0.0649926786499296 1.00054777369121 0.769230769230769 15.3 15 3 small interparietal bone 0.015382122920063 0.0649926786499296 1.00054777369121 0.769230769230769 15.3 15 3 decreased endocochlear potential 0.015382122920063 0.0649926786499296 1.00054777369121 0.769230769230769 15.3 15 3 hyperalgesia 0.015382122920063 0.0649926786499296 1.00054777369121 0.769230769230769 15.3 15 3 orthokeratosis 0.015382122920063 0.0649926786499296 1.00054777369121 0.769230769230769 15.3 15 3 absent hypoglossal nerve 0.015382122920063 0.0649926786499296 1.00054777369121 0.769230769230769 15.3 15 3 abnormal embryonic tissue morphology 1.43224907097689e-16 1.22852398760518e-14 0.999867128947204 0.768707482993197 15.3 15 3 short mandible 3.94551879507103e-07 8.01181877774628e-06 0.998761081238192 0.767857142857143 15.3 15 3 preweaning lethality, complete penetrance 1.41281410625432e-77 2.34291672620508e-74 0.998384427153501 0.767567567567568 15.3 15 3 abnormal axon guidance 9.253806513789e-06 0.000135804387628614 0.998220918403558 0.767441860465116 15.3 15 3 seminiferous tubule degeneration 7.37442921809101e-09 2.02694946740347e-07 0.997806546913976 0.767123287671233 15.3 15 3 astrocytosis 7.37442921809101e-09 2.02694946740347e-07 0.997806546913976 0.767123287671233 15.3 15 3 decreased percent body fat/body weight 7.37442921809101e-09 2.02694946740347e-07 0.997806546913976 0.767123287671233 15.3 15 3 abnormal gait 6.70487152436503e-33 2.2237823889144e-30 0.997633556874636 0.766990291262136 15.3 15 3 abnormal response to new environment 0.000226091751180764 0.00225864751430582 0.997212614445575 0.766666666666667 15.3 15 3 cleft secondary palate 6.06340424254077e-11 2.45247448021466e-09 0.996290123590398 0.765957446808511 15.3 15 3 increased cellular sensitivity to gamma-irradiation 3.90805097729384e-06 6.38492102982983e-05 0.996290123590398 0.765957446808511 15.3 15 3 impaired coordination 1.95619169797257e-36 7.48619515185656e-34 0.996210138834169 0.765895953757225 15.3 15 3 abnormal motor capabilities/coordination/movement 9.94210032998452e-15 6.86971515856569e-13 0.995241838527698 0.765151515151515 15.3 15 3 abnormal extraembryonic tissue morphology 1.12381733588446e-11 5.27452004342001e-10 0.994662198551852 0.764705882352941 15.3 15 3 overexpanded pulmonary alveoli 9.39756491536083e-05 0.00104126693661292 0.994662198551852 0.764705882352941 15.3 15 3 abnormal vagus nerve morphology 0.00602767457169992 0.0323143114161715 0.994662198551852 0.764705882352941 15.3 15 3 increased aggression towards mice 0.00602767457169992 0.0323143114161715 0.994662198551852 0.764705882352941 15.3 15 3 increased regulatory T cell number 0.00602767457169992 0.0323143114161715 0.994662198551852 0.764705882352941 15.3 15 3 increased hepatoma incidence 0.00602767457169992 0.0323143114161715 0.994662198551852 0.764705882352941 15.3 15 3 abnormal electroretinogram waveform feature 0.00602767457169992 0.0323143114161715 0.994662198551852 0.764705882352941 15.3 15 3 embryonic growth arrest 2.39937806130525e-24 4.42107624259023e-22 0.993993967313322 0.764192139737991 15.3 15 3 abnormal brain morphology 1.57931495960649e-17 1.67172168596645e-15 0.993711733001396 0.763975155279503 15.3 15 3 abnormal forebrain development 1.31020063141054e-08 3.41269536192011e-07 0.993599525262801 0.763888888888889 15.3 15 3 abnormal embryo turning 7.0234041767062e-07 1.33364258698906e-05 0.993271062609822 0.763636363636364 15.3 15 3 embryonic lethality between implantation and somite formation, complete penetrance 8.37516963681184e-26 1.66665875772556e-23 0.992788423609525 0.763265306122449 15.3 15 3 persistence of hyaloid vascular system 3.92758083310123e-05 0.000488492866116966 0.992648712319966 0.763157894736842 15.3 15 3 decreased total retina thickness 3.92758083310123e-05 0.000488492866116966 0.992648712319966 0.763157894736842 15.3 15 3 abnormal reproductive system morphology 1.64874720099772e-05 0.000228188734031198 0.991018747275105 0.761904761904762 15.3 15 3 spina bifida 1.64874720099772e-05 0.000228188734031198 0.991018747275105 0.761904761904762 15.3 15 3 small ears 0.00241496460133473 0.0156846591274678 0.991018747275105 0.761904761904762 15.3 15 3 abnormal scapula morphology 0.00241496460133473 0.0156846591274678 0.991018747275105 0.761904761904762 15.3 15 3 liver degeneration 0.00241496460133473 0.0156846591274678 0.991018747275105 0.761904761904762 15.3 15 3 absent segment of posterior cerebral artery 0.00241496460133473 0.0156846591274678 0.991018747275105 0.761904761904762 15.3 15 3 decreased vocalization 0.00241496460133473 0.0156846591274678 0.991018747275105 0.761904761904762 15.3 15 3 decreased white adipose tissue amount 5.42738863999705e-08 1.33011125536873e-06 0.990094289488468 0.761194029850746 15.3 15 3 embryonic lethality during organogenesis, incomplete penetrance 5.72709226306357e-24 9.82492552025561e-22 0.98967225441196 0.760869565217391 15.3 15 3 abnormal forelimb morphology 6.94641840872287e-06 0.000105040825481448 0.98967225441196 0.760869565217391 15.3 15 3 abnormal interventricular septum morphology 2.93552271637115e-06 4.93385997092786e-05 0.988541200406918 0.76 15.3 15 3 short stride length 2.93552271637115e-06 4.93385997092786e-05 0.988541200406918 0.76 15.3 15 3 mandible hypoplasia 0.000981966552102956 0.00762134726476163 0.988541200406918 0.76 15.3 15 3 abnormal thyroid gland morphology 0.000981966552102956 0.00762134726476163 0.988541200406918 0.76 15.3 15 3 decreased embryo size 6.53065297643211e-48 4.06124981971872e-45 0.987779276997663 0.759414225941423 15.3 15 3 pale yolk sac 1.8186458420659e-09 5.76290641036806e-08 0.98728750199169 0.759036144578313 15.3 15 3 blood in lymph vessels 0.000403531970832107 0.00368361753190777 0.986747114743747 0.758620689655172 15.3 15 3 increased tumor incidence 2.2360577798191e-13 1.22246015984616e-11 0.986023693105372 0.758064516129032 15.3 15 3 pericardial effusion 2.2466185955711e-07 4.92375661364152e-06 0.986023693105372 0.758064516129032 15.3 15 3 head tossing 0.000167150298033494 0.00173411936420059 0.985387958938315 0.757575757575758 15.3 15 3 embryonic lethality during organogenesis, complete penetrance 3.62745590944617e-55 3.00776552491578e-52 0.984824880104636 0.757142857142857 15.3 15 3 double outlet right ventricle 1.1418971245086e-11 5.30928803217783e-10 0.984651220277426 0.757009345794392 15.3 15 3 decreased width of hypertrophic chondrocyte zone 6.96651871965372e-05 0.000798581350928048 0.984322674658382 0.756756756756757 15.3 15 3 absent gastric milk in neonates 7.46621780964073e-09 2.02975047010725e-07 0.983871977463025 0.756410256410256 15.3 15 3 increased embryonic tissue cell apoptosis 7.46621780964073e-09 2.02975047010725e-07 0.983871977463025 0.756410256410256 15.3 15 3 abnormal lung morphology 9.10799750558201e-13 4.72002995731985e-11 0.983731844721612 0.756302521008403 15.3 15 3 Leydig cell hyperplasia 2.91785173683642e-05 0.000380031877620454 0.983465250725752 0.75609756097561 15.3 15 3 lethality at weaning, incomplete penetrance 2.91785173683642e-05 0.000380031877620454 0.983465250725752 0.75609756097561 15.3 15 3 increased T cell derived lymphoma incidence 5.177150949956e-06 7.99885899876742e-05 0.982170365603006 0.755102040816326 15.3 15 3 atrioventricular septal defect 2.19049875717336e-06 3.78393448504774e-05 0.981669513810246 0.754716981132076 15.3 15 3 decreased birth body size 3.70381679344382e-12 1.77177774494067e-10 0.981238957005943 0.754385964912281 15.3 15 3 absent vitelline blood vessels 9.29028657187297e-07 1.74411983754974e-05 0.981238957005943 0.754385964912281 15.3 15 3 preweaning lethality, incomplete penetrance 1.42471865140239e-39 6.4436139006608e-37 0.979509360845871 0.753056234718826 15.3 15 3 postnatal lethality 6.58040659078502e-17 6.17689109229348e-15 0.979451886896518 0.753012048192771 15.3 15 3 perinatal lethality, incomplete penetrance 2.21332359247714e-22 3.4410265226793e-20 0.978411760998929 0.752212389380531 15.3 15 3 prenatal lethality, complete penetrance 3.96971953887035e-27 9.40445462184761e-25 0.977873489611159 0.751798561151079 15.3 15 3 respiratory distress 2.13623471788289e-17 2.12555354429348e-15 0.977413721120317 0.751445086705202 15.3 15 3 abnormal kidney development 6.90419606714811e-07 1.31602971011731e-05 0.975534079348932 0.75 15.3 15 3 distended pericardium 3.8362483924833e-06 6.2987906774272e-05 0.975534079348932 0.75 15.3 15 3 eyelids open at birth 3.8362483924833e-06 6.2987906774272e-05 0.975534079348932 0.75 15.3 15 3 kinked neural tube 3.8362483924833e-06 6.2987906774272e-05 0.975534079348932 0.75 15.3 15 3 small superior cervical ganglion 0.00071340699868204 0.00589568076153347 0.975534079348932 0.75 15.3 15 3 straub tail 0.00071340699868204 0.00589568076153347 0.975534079348932 0.75 15.3 15 3 premature aging 0.00071340699868204 0.00589568076153347 0.975534079348932 0.75 15.3 15 3 enhanced coordination 0.00071340699868204 0.00589568076153347 0.975534079348932 0.75 15.3 15 3 increased bone resorption 0.00071340699868204 0.00589568076153347 0.975534079348932 0.75 15.3 15 3 hypoxia 0.00071340699868204 0.00589568076153347 0.975534079348932 0.75 15.3 15 3 prolonged QRS complex duration 0.00071340699868204 0.00589568076153347 0.975534079348932 0.75 15.3 15 3 decreased body height 0.00174159501290196 0.0120172471417299 0.975534079348932 0.75 15.3 15 3 decreased metastatic potential 0.00174159501290196 0.0120172471417299 0.975534079348932 0.75 15.3 15 3 ocular hypertelorism 0.00174159501290196 0.0120172471417299 0.975534079348932 0.75 15.3 15 3 increased stereotypic behavior 0.00174159501290196 0.0120172471417299 0.975534079348932 0.75 15.3 15 3 blindness 0.00174159501290196 0.0120172471417299 0.975534079348932 0.75 15.3 15 3 increased body temperature 0.00174159501290196 0.0120172471417299 0.975534079348932 0.75 15.3 15 3 abnormal inner cell mass apoptosis 0.00174159501290196 0.0120172471417299 0.975534079348932 0.75 15.3 15 3 abnormal lung saccule morphology 0.00174159501290196 0.0120172471417299 0.975534079348932 0.75 15.3 15 3 abnormal adipose tissue distribution 0.0278198226443968 0.104692600344837 0.975534079348932 0.75 15.3 15 3 decreased digestive secretion 0.0278198226443968 0.104692600344837 0.975534079348932 0.75 15.3 15 3 amyloidosis 0.0278198226443968 0.104692600344837 0.975534079348932 0.75 15.3 15 3 mesocardia 0.0278198226443968 0.104692600344837 0.975534079348932 0.75 15.3 15 3 abnormal superior cervical ganglion morphology 0.0278198226443968 0.104692600344837 0.975534079348932 0.75 15.3 15 3 abnormal enteric nervous system morphology 0.0278198226443968 0.104692600344837 0.975534079348932 0.75 15.3 15 3 increased growth rate 0.0278198226443968 0.104692600344837 0.975534079348932 0.75 15.3 15 3 abnormal aorta elastic fiber morphology 0.0278198226443968 0.104692600344837 0.975534079348932 0.75 15.3 15 3 abnormal alisphenoid bone morphology 0.0278198226443968 0.104692600344837 0.975534079348932 0.75 15.3 15 3 abnormal defecation 0.0278198226443968 0.104692600344837 0.975534079348932 0.75 15.3 15 3 decreased cochlear nerve compound action potential 0.0278198226443968 0.104692600344837 0.975534079348932 0.75 15.3 15 3 hematuria 0.0278198226443968 0.104692600344837 0.975534079348932 0.75 15.3 15 3 abnormal palatine bone morphology 0.0278198226443968 0.104692600344837 0.975534079348932 0.75 15.3 15 3 hemoperitoneum 0.0278198226443968 0.104692600344837 0.975534079348932 0.75 15.3 15 3 abnormal thymus corticomedullary boundary morphology 0.0278198226443968 0.104692600344837 0.975534079348932 0.75 15.3 15 3 reduced cerebellar foliation 0.0278198226443968 0.104692600344837 0.975534079348932 0.75 15.3 15 3 increased fibrosarcoma incidence 0.0278198226443968 0.104692600344837 0.975534079348932 0.75 15.3 15 3 increased skeletal muscle glycogen level 0.0278198226443968 0.104692600344837 0.975534079348932 0.75 15.3 15 3 abnormal pulmonary valve cusp morphology 0.0278198226443968 0.104692600344837 0.975534079348932 0.75 15.3 15 3 abnormal colon goblet cell morphology 0.0278198226443968 0.104692600344837 0.975534079348932 0.75 15.3 15 3 abnormal vitelline vein connection 0.0278198226443968 0.104692600344837 0.975534079348932 0.75 15.3 15 3 perinatal lethality 5.12736606786174e-05 0.000613188610279138 0.975534079348932 0.75 15.3 15 3 scoliosis 0.000294774719607509 0.0028365652418711 0.975534079348932 0.75 15.3 15 3 pancreatic islet hyperplasia 0.000294774719607509 0.0028365652418711 0.975534079348932 0.75 15.3 15 3 abnormal vascular regression 0.00430155940484917 0.0245979977461203 0.975534079348932 0.75 15.3 15 3 increased mammary adenocarcinoma incidence 0.00430155940484917 0.0245979977461203 0.975534079348932 0.75 15.3 15 3 abnormal dopamine level 0.00430155940484917 0.0245979977461203 0.975534079348932 0.75 15.3 15 3 abnormal male reproductive system physiology 0.00430155940484917 0.0245979977461203 0.975534079348932 0.75 15.3 15 3 abnormal optic stalk morphology 0.00430155940484917 0.0245979977461203 0.975534079348932 0.75 15.3 15 3 abnormal response to tactile stimuli 0.00430155940484917 0.0245979977461203 0.975534079348932 0.75 15.3 15 3 abnormal sperm mitochondrial sheath morphology 0.00430155940484917 0.0245979977461203 0.975534079348932 0.75 15.3 15 3 increased skin tumor incidence 0.00430155940484917 0.0245979977461203 0.975534079348932 0.75 15.3 15 3 decreased muscle cell glucose uptake 0.00430155940484917 0.0245979977461203 0.975534079348932 0.75 15.3 15 3 failure of tooth eruption 0.0108017472102041 0.0509371491666024 0.975534079348932 0.75 15.3 15 3 paternal imprinting 0.0108017472102041 0.0509371491666024 0.975534079348932 0.75 15.3 15 3 small pancreas 0.0108017472102041 0.0509371491666024 0.975534079348932 0.75 15.3 15 3 loose skin 0.0108017472102041 0.0509371491666024 0.975534079348932 0.75 15.3 15 3 decreased creatinine clearance 0.0108017472102041 0.0509371491666024 0.975534079348932 0.75 15.3 15 3 decreased skeletal muscle weight 0.0108017472102041 0.0509371491666024 0.975534079348932 0.75 15.3 15 3 increased heart left ventricle size 0.0108017472102041 0.0509371491666024 0.975534079348932 0.75 15.3 15 3 dilated respiratory conducting tubes 0.0108017472102041 0.0509371491666024 0.975534079348932 0.75 15.3 15 3 abnormal pulmonary alveolus wall morphology 0.0108017472102041 0.0509371491666024 0.975534079348932 0.75 15.3 15 3 decreased fibroblast apoptosis 0.0108017472102041 0.0509371491666024 0.975534079348932 0.75 15.3 15 3 decreased adipocyte glucose uptake 0.0108017472102041 0.0509371491666024 0.975534079348932 0.75 15.3 15 3 abnormal exoccipital bone morphology 0.074846904710737 0.216364526981939 0.975534079348932 0.75 15.3 15 3 enlarged pituitary gland 0.074846904710737 0.216364526981939 0.975534079348932 0.75 15.3 15 3 abnormal vagus ganglion morphology 0.074846904710737 0.216364526981939 0.975534079348932 0.75 15.3 15 3 increased sensitivity to skin irradiation 0.074846904710737 0.216364526981939 0.975534079348932 0.75 15.3 15 3 dermal cysts 0.074846904710737 0.216364526981939 0.975534079348932 0.75 15.3 15 3 poor grooming 0.074846904710737 0.216364526981939 0.975534079348932 0.75 15.3 15 3 abnormal urination 0.074846904710737 0.216364526981939 0.975534079348932 0.75 15.3 15 3 abnormal atrial thrombosis 0.074846904710737 0.216364526981939 0.975534079348932 0.75 15.3 15 3 abnormal pulmonary circulation 0.074846904710737 0.216364526981939 0.975534079348932 0.75 15.3 15 3 head spot 0.074846904710737 0.216364526981939 0.975534079348932 0.75 15.3 15 3 altered response to CNS ischemic injury 0.074846904710737 0.216364526981939 0.975534079348932 0.75 15.3 15 3 hypospadia 0.074846904710737 0.216364526981939 0.975534079348932 0.75 15.3 15 3 absent tympanic ring 0.074846904710737 0.216364526981939 0.975534079348932 0.75 15.3 15 3 decreased susceptibility to age related obesity 0.074846904710737 0.216364526981939 0.975534079348932 0.75 15.3 15 3 liver cysts 0.074846904710737 0.216364526981939 0.975534079348932 0.75 15.3 15 3 increased cardiac output 0.074846904710737 0.216364526981939 0.975534079348932 0.75 15.3 15 3 abnormal platelet shape 0.074846904710737 0.216364526981939 0.975534079348932 0.75 15.3 15 3 binucleate 0.074846904710737 0.216364526981939 0.975534079348932 0.75 15.3 15 3 increased left ventricle systolic pressure 0.074846904710737 0.216364526981939 0.975534079348932 0.75 15.3 15 3 lymph node inflammation 0.074846904710737 0.216364526981939 0.975534079348932 0.75 15.3 15 3 abnormal miscarriage rate 0.074846904710737 0.216364526981939 0.975534079348932 0.75 15.3 15 3 abnormal hair follicle melanocyte morphology 0.074846904710737 0.216364526981939 0.975534079348932 0.75 15.3 15 3 absent interparietal bone 0.074846904710737 0.216364526981939 0.975534079348932 0.75 15.3 15 3 abnormal kidney epithelium morphology 0.074846904710737 0.216364526981939 0.975534079348932 0.75 15.3 15 3 abnormal NK cell morphology 0.074846904710737 0.216364526981939 0.975534079348932 0.75 15.3 15 3 abnormal somite size 0.074846904710737 0.216364526981939 0.975534079348932 0.75 15.3 15 3 ectrodactyly 0.074846904710737 0.216364526981939 0.975534079348932 0.75 15.3 15 3 ocular hypertension 0.074846904710737 0.216364526981939 0.975534079348932 0.75 15.3 15 3 abnormal ilium morphology 0.074846904710737 0.216364526981939 0.975534079348932 0.75 15.3 15 3 increased pulmonary ventilation 0.074846904710737 0.216364526981939 0.975534079348932 0.75 15.3 15 3 abnormal lateral plate mesoderm morphology 0.074846904710737 0.216364526981939 0.975534079348932 0.75 15.3 15 3 heart right ventricle hypoplasia 0.074846904710737 0.216364526981939 0.975534079348932 0.75 15.3 15 3 abnormal hepatic vein morphology 0.074846904710737 0.216364526981939 0.975534079348932 0.75 15.3 15 3 sinoatrial block 0.074846904710737 0.216364526981939 0.975534079348932 0.75 15.3 15 3 increased heart right ventricle size 0.074846904710737 0.216364526981939 0.975534079348932 0.75 15.3 15 3 delayed suture closure 0.074846904710737 0.216364526981939 0.975534079348932 0.75 15.3 15 3 abnormal heart right ventricle pressure 0.074846904710737 0.216364526981939 0.975534079348932 0.75 15.3 15 3 abnormal stomach position or orientation 0.074846904710737 0.216364526981939 0.975534079348932 0.75 15.3 15 3 absent ureteric bud 0.074846904710737 0.216364526981939 0.975534079348932 0.75 15.3 15 3 abnormal branching involved in ureteric bud morphogenesis 0.074846904710737 0.216364526981939 0.975534079348932 0.75 15.3 15 3 abnormal macrophage activation involved in immune response 0.074846904710737 0.216364526981939 0.975534079348932 0.75 15.3 15 3 lethality during fetal growth through weaning, incomplete penetrance 0.074846904710737 0.216364526981939 0.975534079348932 0.75 15.3 15 3 decreased cranium length 0.074846904710737 0.216364526981939 0.975534079348932 0.75 15.3 15 3 abnormal heart echocardiography feature 0.074846904710737 0.216364526981939 0.975534079348932 0.75 15.3 15 3 prolonged PQ interval 0.074846904710737 0.216364526981939 0.975534079348932 0.75 15.3 15 3 absent hypoglossal canal 0.074846904710737 0.216364526981939 0.975534079348932 0.75 15.3 15 3 abnormal motor coordination/ balance 2.46108317619099e-10 9.20593142973697e-09 0.972249452819137 0.747474747474748 15.3 15 3 decreased circulating total protein level 2.82920861660839e-06 4.7875213835465e-05 0.969621751595302 0.745454545454545 15.3 15 3 abnormal trophoblast layer morphology 6.67901875594378e-06 0.000102240364033293 0.969158039614625 0.745098039215686 15.3 15 3 cyanosis 2.16368787314453e-18 2.56293980211763e-16 0.968759537131231 0.744791666666667 15.3 15 3 abnormal cell nucleus morphology 1.58083234170576e-05 0.000222164997174751 0.96861539793511 0.74468085106383 15.3 15 3 abnormal organ of Corti morphology 3.75308625443426e-05 0.00047356763851562 0.967971799664056 0.744186046511628 15.3 15 3 abnormal vasculogenesis 3.75308625443426e-05 0.00047356763851562 0.967971799664056 0.744186046511628 15.3 15 3 delayed endochondral bone ossification 3.75308625443426e-05 0.00047356763851562 0.967971799664056 0.744186046511628 15.3 15 3 abnormal heart ventricle morphology 2.93690301809934e-08 7.34225754524836e-07 0.967196181234838 0.743589743589744 15.3 15 3 abnormal heart looping 8.94296729743135e-05 0.000997529767073549 0.967196181234838 0.743589743589744 15.3 15 3 pale liver 6.86636612124489e-08 1.63740190221019e-06 0.966745484039482 0.743243243243243 15.3 15 3 impaired swimming 3.7665830524698e-07 7.77541522242209e-06 0.965680199759549 0.742424242424242 15.3 15 3 neonatal lethality, incomplete penetrance 5.20914812180664e-24 9.2555399664243e-22 0.96552860161202 0.742307692307692 15.3 15 3 hypoglycemia 1.71090368208508e-09 5.45624731947004e-08 0.965044465592492 0.741935483870968 15.3 15 3 abnormal capillary morphology 0.000515131000818612 0.00456822946358751 0.965044465592492 0.741935483870968 15.3 15 3 inner cell mass degeneration 0.000515131000818612 0.00456822946358751 0.965044465592492 0.741935483870968 15.3 15 3 pale kidney 0.000515131000818612 0.00456822946358751 0.965044465592492 0.741935483870968 15.3 15 3 abnormal muscle physiology 3.98553163359068e-09 1.18730657946788e-07 0.964573022277595 0.741573033707865 15.3 15 3 reduced fertility 2.0582980696412e-13 1.15056549398483e-11 0.963837028037794 0.741007194244604 15.3 15 3 abnormal eye morphology 2.0582980696412e-13 1.15056549398483e-11 0.963837028037794 0.741007194244604 15.3 15 3 abnormal neural tube morphology 2.28877905276306e-15 1.67451114522003e-13 0.963490448739686 0.740740740740741 15.3 15 3 increased cell proliferation 4.89556649159014e-06 7.73188676052728e-05 0.963490448739686 0.740740740740741 15.3 15 3 neurodegeneration 4.89556649159014e-06 7.73188676052728e-05 0.963490448739686 0.740740740740741 15.3 15 3 abnormal heart valve morphology 0.00124839124031199 0.00932544507590415 0.963490448739686 0.740740740740741 15.3 15 3 abnormal trigeminal nerve morphology 0.00124839124031199 0.00932544507590415 0.963490448739686 0.740740740740741 15.3 15 3 decreased circulating fructosamine level 0.00124839124031199 0.00932544507590415 0.963490448739686 0.740740740740741 15.3 15 3 thick interventricular septum 0.00124839124031199 0.00932544507590415 0.963490448739686 0.740740740740741 15.3 15 3 prenatal lethality, incomplete penetrance 1.90438626101612e-27 4.73716082427761e-25 0.962698104620657 0.740131578947368 15.3 15 3 kyphosis 2.84155980823189e-14 1.78946329695616e-12 0.962526958290946 0.74 15.3 15 3 abnormal vitelline vasculature morphology 3.20066524928308e-11 1.40914244382153e-09 0.961395904285904 0.739130434782609 15.3 15 3 perimembraneous ventricular septal defect 2.76826268424315e-07 5.94792104731847e-06 0.961395904285904 0.739130434782609 15.3 15 3 abnormal allantois morphology 2.73545224038533e-05 0.000361938162125453 0.961395904285904 0.739130434782609 15.3 15 3 abnormal myelin sheath morphology 2.73545224038533e-05 0.000361938162125453 0.961395904285904 0.739130434782609 15.3 15 3 abnormal circulating insulin level 0.00305294438931523 0.018658966015778 0.961395904285904 0.739130434782609 15.3 15 3 abnormal cochlear ganglion morphology 0.00305294438931523 0.018658966015778 0.961395904285904 0.739130434782609 15.3 15 3 abnormal palatal shelf fusion at midline 0.00305294438931523 0.018658966015778 0.961395904285904 0.739130434782609 15.3 15 3 decreased effector memory CD8-positive, alpha-beta T cell number 0.00305294438931523 0.018658966015778 0.961395904285904 0.739130434782609 15.3 15 3 abnormal vertebral artery topology 0.00305294438931523 0.018658966015778 0.961395904285904 0.739130434782609 15.3 15 3 hyperglycemia 6.84743472956089e-09 1.93649009890768e-07 0.960753259964857 0.738636363636364 15.3 15 3 disheveled coat 6.49441906510926e-05 0.000760229055268672 0.960049411422758 0.738095238095238 15.3 15 3 abnormal reproductive system physiology 0.000154755448020005 0.00164510332029813 0.958419446377898 0.736842105263158 15.3 15 3 enlarged adrenal glands 0.00755811582761513 0.0376016262423853 0.958419446377898 0.736842105263158 15.3 15 3 abnormal ear morphology 0.00755811582761513 0.0376016262423853 0.958419446377898 0.736842105263158 15.3 15 3 abnormal nasal septum morphology 0.00755811582761513 0.0376016262423853 0.958419446377898 0.736842105263158 15.3 15 3 decreased fertilization frequency 0.00755811582761513 0.0376016262423853 0.958419446377898 0.736842105263158 15.3 15 3 decreased circulating magnesium level 0.00755811582761513 0.0376016262423853 0.958419446377898 0.736842105263158 15.3 15 3 increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 0.00755811582761513 0.0376016262423853 0.958419446377898 0.736842105263158 15.3 15 3 embryonic lethality between implantation and somite formation, incomplete penetrance 0.00755811582761513 0.0376016262423853 0.958419446377898 0.736842105263158 15.3 15 3 small spleen 5.03530188689668e-09 1.46494894077842e-07 0.957667154818732 0.736263736263736 15.3 15 3 abnormal bone structure 1.7690606310951e-17 1.79613808973431e-15 0.957000616701543 0.735751295336788 15.3 15 3 abnormal embryo development 1.03144762039334e-12 5.18328475904732e-11 0.956405960146012 0.735294117647059 15.3 15 3 ventricular septal defect 1.03144762039334e-12 5.18328475904732e-11 0.956405960146012 0.735294117647059 15.3 15 3 short maxilla 0.000370413211588732 0.00341893455965481 0.956405960146012 0.735294117647059 15.3 15 3 abnormal oocyte morphology 0.000370413211588732 0.00341893455965481 0.956405960146012 0.735294117647059 15.3 15 3 abnormal brown adipose tissue morphology 0.000370413211588732 0.00341893455965481 0.956405960146012 0.735294117647059 15.3 15 3 abnormal direction of heart looping 0.000370413211588732 0.00341893455965481 0.956405960146012 0.735294117647059 15.3 15 3 premature death 2.80400651315037e-73 3.48748310073077e-70 0.956272663148082 0.735191637630662 15.3 15 3 decreased startle reflex 4.03257581442248e-11 1.71470638262836e-09 0.956078983749381 0.735042735042735 15.3 15 3 abnormal osteoclast physiology 1.11118261028569e-06 2.03240201697474e-05 0.955210452695829 0.734375 15.3 15 3 abnormal heart development 1.95416304284732e-14 1.2792054129165e-12 0.954953191598954 0.734177215189873 15.3 15 3 abnormal placenta labyrinth morphology 6.36122086235746e-08 1.52884414445548e-06 0.954953191598954 0.734177215189873 15.3 15 3 abnormal myocardium layer morphology 6.36122086235746e-08 1.52884414445548e-06 0.954953191598954 0.734177215189873 15.3 15 3 postnatal lethality, incomplete penetrance 3.18881923973067e-48 2.26633938823715e-45 0.954924204433109 0.734154929577465 15.3 15 3 increased anxiety-related response 7.59132020475818e-13 4.01774659773106e-11 0.954479386988883 0.733812949640288 15.3 15 3 abnormal optic cup morphology 0.000891492574873301 0.00698725907359037 0.953855544252289 0.733333333333333 15.3 15 3 abnormal fontanelle morphology 0.0190418341702829 0.0772700856420532 0.953855544252289 0.733333333333333 15.3 15 3 absent incisors 0.0190418341702829 0.0772700856420532 0.953855544252289 0.733333333333333 15.3 15 3 macrocytosis 0.0190418341702829 0.0772700856420532 0.953855544252289 0.733333333333333 15.3 15 3 decreased hepatocyte number 0.0190418341702829 0.0772700856420532 0.953855544252289 0.733333333333333 15.3 15 3 no suckling reflex 0.0190418341702829 0.0772700856420532 0.953855544252289 0.733333333333333 15.3 15 3 audiogenic seizures 0.0190418341702829 0.0772700856420532 0.953855544252289 0.733333333333333 15.3 15 3 absent egg cylinders 0.0190418341702829 0.0772700856420532 0.953855544252289 0.733333333333333 15.3 15 3 abnormal lymph node B cell domain morphology 0.0190418341702829 0.0772700856420532 0.953855544252289 0.733333333333333 15.3 15 3 dilated ureter 0.0190418341702829 0.0772700856420532 0.953855544252289 0.733333333333333 15.3 15 3 abnormal glial cell morphology 0.0190418341702829 0.0772700856420532 0.953855544252289 0.733333333333333 15.3 15 3 abnormal ear development 0.0190418341702829 0.0772700856420532 0.953855544252289 0.733333333333333 15.3 15 3 immune system phenotype 0.0190418341702829 0.0772700856420532 0.953855544252289 0.733333333333333 15.3 15 3 abnormal neurotransmitter secretion 0.0190418341702829 0.0772700856420532 0.953855544252289 0.733333333333333 15.3 15 3 decreased thymocyte apoptosis 0.0190418341702829 0.0772700856420532 0.953855544252289 0.733333333333333 15.3 15 3 abnormal microglial cell activation 0.0190418341702829 0.0772700856420532 0.953855544252289 0.733333333333333 15.3 15 3 increased circulating corticosterone level 4.70064959411884e-05 0.000564872747119354 0.953855544252289 0.733333333333333 15.3 15 3 hemopericardium 0.000111533142433853 0.00121683636756233 0.95174056521847 0.731707317073171 15.3 15 3 abnormal nasal bone morphology 0.00216057784090908 0.0144086793009688 0.950520385006652 0.730769230769231 15.3 15 3 heart inflammation 0.00216057784090908 0.0144086793009688 0.950520385006652 0.730769230769231 15.3 15 3 decreased grip strength 5.27222187310265e-19 6.90244837333834e-17 0.950291949441882 0.730593607305936 15.3 15 3 anemia 2.80484085118492e-18 3.24513563596394e-16 0.949334901862468 0.729857819905213 15.3 15 3 malocclusion 0.000265578604000782 0.00259069324490959 0.949168293420582 0.72972972972973 15.3 15 3 abnormal breathing pattern 0.000265578604000782 0.00259069324490959 0.949168293420582 0.72972972972973 15.3 15 3 abnormal calcium ion homeostasis 0.000265578604000782 0.00259069324490959 0.949168293420582 0.72972972972973 15.3 15 3 respiratory failure 2.19965963643782e-13 1.21592296569758e-11 0.947538620118168 0.728476821192053 15.3 15 3 perinatal lethality, complete penetrance 3.47331211041355e-18 3.92721085211532e-16 0.946527588726663 0.727699530516432 15.3 15 3 decreased brown adipose tissue amount 0.000635106510471546 0.00533993106378824 0.945972440580783 0.727272727272727 15.3 15 3 abnormal QRS complex 0.000635106510471546 0.00533993106378824 0.945972440580783 0.727272727272727 15.3 15 3 increased mean corpuscular hemoglobin 3.34853634883272e-09 1.00355230936402e-07 0.945972440580782 0.727272727272727 15.3 15 3 increased body size 0.0052838374177577 0.0291754618794057 0.945972440580782 0.727272727272727 15.3 15 3 increased skin papilloma incidence 0.0052838374177577 0.0291754618794057 0.945972440580782 0.727272727272727 15.3 15 3 abnormal chorion morphology 0.0052838374177577 0.0291754618794057 0.945972440580782 0.727272727272727 15.3 15 3 abnormal vascular branching morphogenesis 0.0052838374177577 0.0291754618794057 0.945972440580782 0.727272727272727 15.3 15 3 decreased cardiac output 0.0052838374177577 0.0291754618794057 0.945972440580782 0.727272727272727 15.3 15 3 abnormal retinal outer plexiform layer morphology 0.0052838374177577 0.0291754618794057 0.945972440580782 0.727272727272727 15.3 15 3 abnormal limb posture 0.0052838374177577 0.0291754618794057 0.945972440580782 0.727272727272727 15.3 15 3 abnormal mesenteric lymph node morphology 0.0052838374177577 0.0291754618794057 0.945972440580782 0.727272727272727 15.3 15 3 increased bone volume 0.0052838374177577 0.0291754618794057 0.945972440580782 0.727272727272727 15.3 15 3 premature suture closure 0.0492855520865293 0.157783540302756 0.945972440580782 0.727272727272727 15.3 15 3 abnormal thrombopoiesis 0.0492855520865293 0.157783540302756 0.945972440580782 0.727272727272727 15.3 15 3 abnormal large intestine morphology 0.0492855520865293 0.157783540302756 0.945972440580782 0.727272727272727 15.3 15 3 abnormal hemoglobin 0.0492855520865293 0.157783540302756 0.945972440580782 0.727272727272727 15.3 15 3 focal hepatic necrosis 0.0492855520865293 0.157783540302756 0.945972440580782 0.727272727272727 15.3 15 3 vasculitis 0.0492855520865293 0.157783540302756 0.945972440580782 0.727272727272727 15.3 15 3 secondary sex reversal 0.0492855520865293 0.157783540302756 0.945972440580782 0.727272727272727 15.3 15 3 abnormal primary sex determination 0.0492855520865293 0.157783540302756 0.945972440580782 0.727272727272727 15.3 15 3 abnormal vestibular ganglion morphology 0.0492855520865293 0.157783540302756 0.945972440580782 0.727272727272727 15.3 15 3 decreased post-tetanic potentiation 0.0492855520865293 0.157783540302756 0.945972440580782 0.727272727272727 15.3 15 3 allodynia 0.0492855520865293 0.157783540302756 0.945972440580782 0.727272727272727 15.3 15 3 abnormal radial glial cell morphology 0.0492855520865293 0.157783540302756 0.945972440580782 0.727272727272727 15.3 15 3 dilated renal glomerular capsule 0.0492855520865293 0.157783540302756 0.945972440580782 0.727272727272727 15.3 15 3 abnormal pituitary gland development 0.0492855520865293 0.157783540302756 0.945972440580782 0.727272727272727 15.3 15 3 abnormal crista ampullaris neuroepithelium morphology 0.0492855520865293 0.157783540302756 0.945972440580782 0.727272727272727 15.3 15 3 abnormal palate development 0.0492855520865293 0.157783540302756 0.945972440580782 0.727272727272727 15.3 15 3 enhanced behavioral response to addictive substance 0.0492855520865293 0.157783540302756 0.945972440580782 0.727272727272727 15.3 15 3 palatal shelf hypoplasia 0.0492855520865293 0.157783540302756 0.945972440580782 0.727272727272727 15.3 15 3 abnormal palatal shelf elevation 0.0492855520865293 0.157783540302756 0.945972440580782 0.727272727272727 15.3 15 3 aberrant origin of the right subclavian artery 0.0492855520865293 0.157783540302756 0.945972440580782 0.727272727272727 15.3 15 3 aorta dilation 0.0492855520865293 0.157783540302756 0.945972440580782 0.727272727272727 15.3 15 3 abnormal pulmonary alveolar sac morphology 0.0492855520865293 0.157783540302756 0.945972440580782 0.727272727272727 15.3 15 3 decreased core body temperature 0.0492855520865293 0.157783540302756 0.945972440580782 0.727272727272727 15.3 15 3 chylous ascites 0.0492855520865293 0.157783540302756 0.945972440580782 0.727272727272727 15.3 15 3 impaired righting response 7.75728522097989e-09 2.08608075537162e-07 0.944727740001071 0.726315789473684 15.3 15 3 decreased birth weight 7.75728522097989e-09 2.08608075537162e-07 0.944727740001071 0.726315789473684 15.3 15 3 abnormal fertility/fecundity 4.2710121355465e-07 8.60254468596916e-06 0.94435262475787 0.726027397260274 15.3 15 3 abnormal locomotor activation 1.79749460363065e-08 4.58591571951923e-07 0.943373615194572 0.725274725274725 15.3 15 3 increased grip strength 1.79749460363065e-08 4.58591571951923e-07 0.943373615194572 0.725274725274725 15.3 15 3 decreased spleen weight 9.94855095656012e-07 1.84679257495845e-05 0.942545004201866 0.72463768115942 15.3 15 3 decreased body size 4.44433657977158e-63 4.42211489687272e-60 0.942119795929294 0.724310776942356 15.3 15 3 abnormal microglial cell morphology 0.00152682894678812 0.0107439519240041 0.941894973164486 0.724137931034483 15.3 15 3 abnormal spinal nerve morphology 0.00152682894678812 0.0107439519240041 0.941894973164486 0.724137931034483 15.3 15 3 increased mortality induced by gamma-irradiation 0.00152682894678812 0.0107439519240041 0.941894973164486 0.724137931034483 15.3 15 3 neuron degeneration 5.75522736000884e-05 0.000680101095392968 0.940940672279821 0.723404255319149 15.3 15 3 azoospermia 1.44240656765576e-13 8.44232079304398e-12 0.940766617401486 0.723270440251572 15.3 15 3 renal hypoplasia 0.000451764753804316 0.00409386092928319 0.939403187521194 0.722222222222222 15.3 15 3 underdeveloped hair follicles 0.013080607636332 0.0595389048405778 0.939403187521194 0.722222222222222 15.3 15 3 cortical renal glomerulopathies 0.013080607636332 0.0595389048405778 0.939403187521194 0.722222222222222 15.3 15 3 right pulmonary isomerism 0.013080607636332 0.0595389048405778 0.939403187521194 0.722222222222222 15.3 15 3 absent spleen 0.013080607636332 0.0595389048405778 0.939403187521194 0.722222222222222 15.3 15 3 abnormal phrenic nerve morphology 0.013080607636332 0.0595389048405778 0.939403187521194 0.722222222222222 15.3 15 3 abnormal metacarpal bone morphology 0.013080607636332 0.0595389048405778 0.939403187521194 0.722222222222222 15.3 15 3 abnormal redox activity 0.013080607636332 0.0595389048405778 0.939403187521194 0.722222222222222 15.3 15 3 increased circulating renin level 0.013080607636332 0.0595389048405778 0.939403187521194 0.722222222222222 15.3 15 3 abnormal body wall morphology 0.013080607636332 0.0595389048405778 0.939403187521194 0.722222222222222 15.3 15 3 increased circulating glycerol level 0.013080607636332 0.0595389048405778 0.939403187521194 0.722222222222222 15.3 15 3 absent inner cell mass 0.013080607636332 0.0595389048405778 0.939403187521194 0.722222222222222 15.3 15 3 abnormal glycogen homeostasis 0.013080607636332 0.0595389048405778 0.939403187521194 0.722222222222222 15.3 15 3 small thoracic cage 0.013080607636332 0.0595389048405778 0.939403187521194 0.722222222222222 15.3 15 3 abnormal aerobic respiration 0.013080607636332 0.0595389048405778 0.939403187521194 0.722222222222222 15.3 15 3 abnormal metanephric mesenchyme morphology 0.013080607636332 0.0595389048405778 0.939403187521194 0.722222222222222 15.3 15 3 hydroencephaly 4.06132196763059e-10 1.45360264668793e-08 0.938774824185059 0.721739130434783 15.3 15 3 decreased total body fat amount 1.41230361950093e-26 2.92758771125713e-24 0.938537776938493 0.721556886227545 15.3 15 3 hypoactivity 8.40101804446032e-30 2.45853322183471e-27 0.93844480842762 0.721485411140584 15.3 15 3 decreased body weight 4.80806921711091e-96 2.39201443551268e-92 0.938235791985564 0.721324717285945 15.3 15 3 kidney failure 0.000135761954926863 0.00145250693712074 0.937722680924555 0.720930232558139 15.3 15 3 decreased mean corpuscular hemoglobin 1.67321341507246e-06 2.96236182917634e-05 0.937277840943091 0.720588235294118 15.3 15 3 abnormal energy expenditure 0.00369492534067083 0.0216007680021591 0.936512716174975 0.72 15.3 15 3 spleen hyperplasia 5.19634943284453e-07 1.02181179558899e-05 0.936512716174975 0.72 15.3 15 3 abnormal limb morphology 5.19634943284453e-07 1.02181179558899e-05 0.936512716174975 0.72 15.3 15 3 decreased rib number 5.06009965553952e-08 1.24623741516382e-06 0.935343536754032 0.719101123595506 15.3 15 3 failure of primitive streak formation 0.00107826371946921 0.00827833642648044 0.934886826042726 0.71875 15.3 15 3 abnormal lumbar vertebrae morphology 0.00107826371946921 0.00827833642648044 0.934886826042726 0.71875 15.3 15 3 bradykinesia 0.00107826371946921 0.00827833642648044 0.934886826042726 0.71875 15.3 15 3 increased fibroblast apoptosis 0.00107826371946921 0.00827833642648044 0.934886826042726 0.71875 15.3 15 3 increased hepatocyte apoptosis 0.000321039239045401 0.00304222897952546 0.933844588778465 0.717948717948718 15.3 15 3 decreased B-1 B cell number 0.000321039239045401 0.00304222897952546 0.933844588778465 0.717948717948718 15.3 15 3 atrial septal defect 9.68922749205777e-05 0.00106882276658509 0.933119554159848 0.717391304347826 15.3 15 3 postnatal growth retardation 2.99984622058443e-46 1.49242349474075e-43 0.933027147786887 0.717320261437909 15.3 15 3 decreased circulating serum albumin level 1.14618212980682e-08 3.00118741883627e-07 0.932833934461605 0.717171717171717 15.3 15 3 neonatal lethality, complete penetrance 1.04746617389782e-34 3.72224586795832e-32 0.932747496921347 0.717105263157895 15.3 15 3 epidermal hyperplasia 9.06608287245883e-06 0.000133443083699653 0.932177009155646 0.716666666666667 15.3 15 3 abnormal eating behavior 9.06608287245883e-06 0.000133443083699653 0.932177009155646 0.716666666666667 15.3 15 3 absent mesoderm 9.06608287245883e-06 0.000133443083699653 0.932177009155646 0.716666666666667 15.3 15 3 intracranial hemorrhage 9.06608287245883e-06 0.000133443083699653 0.932177009155646 0.716666666666667 15.3 15 3 abnormal cranium morphology 3.54547220603631e-11 1.52057967457161e-09 0.931853448930323 0.716417910447761 15.3 15 3 decreased body length 3.64881293984973e-21 5.33907187522129e-19 0.930436396848616 0.715328467153285 15.3 15 3 decreased leukocyte cell number 2.56728798280366e-11 1.15065384814849e-09 0.930436396848616 0.715328467153285 15.3 15 3 edema 8.12081333273611e-14 4.98778349757557e-12 0.930160401239679 0.715116279069767 15.3 15 3 organ of Corti degeneration 6.90983186347187e-05 0.00079450911008472 0.929080075570411 0.714285714285714 15.3 15 3 absent kidney 6.90983186347187e-05 0.00079450911008472 0.929080075570411 0.714285714285714 15.3 15 3 decreased circulating creatinine level 6.90983186347187e-05 0.00079450911008472 0.929080075570411 0.714285714285714 15.3 15 3 abnormal neuron differentiation 1.87996994330969e-09 5.80922389314641e-08 0.929080075570411 0.714285714285714 15.3 15 3 thick pulmonary interalveolar septum 0.00076133295722766 0.00609228947829097 0.929080075570411 0.714285714285714 15.3 15 3 increased circulating serum albumin level 0.00076133295722766 0.00609228947829097 0.929080075570411 0.714285714285714 15.3 15 3 abnormal respiration 0.00258585184438686 0.0166640063806018 0.929080075570411 0.714285714285714 15.3 15 3 abnormal hormone level 0.00258585184438686 0.0166640063806018 0.929080075570411 0.714285714285714 15.3 15 3 abnormal mitotic spindle morphology 0.00258585184438686 0.0166640063806018 0.929080075570411 0.714285714285714 15.3 15 3 subcutaneous edema 0.00258585184438686 0.0166640063806018 0.929080075570411 0.714285714285714 15.3 15 3 abnormal blood flow velocity 0.0329477009094409 0.118521194522392 0.929080075570411 0.714285714285714 15.3 15 3 megacephaly 0.0329477009094409 0.118521194522392 0.929080075570411 0.714285714285714 15.3 15 3 abnormal kidney blood vessel morphology 0.0329477009094409 0.118521194522392 0.929080075570411 0.714285714285714 15.3 15 3 translucent skin 0.0329477009094409 0.118521194522392 0.929080075570411 0.714285714285714 15.3 15 3 increased lactate dehydrogenase level 0.0329477009094409 0.118521194522392 0.929080075570411 0.714285714285714 15.3 15 3 abnormal prepulse inhibition 0.0329477009094409 0.118521194522392 0.929080075570411 0.714285714285714 15.3 15 3 abnormal ventral body wall morphology 0.0329477009094409 0.118521194522392 0.929080075570411 0.714285714285714 15.3 15 3 abnormal uterus development 0.0329477009094409 0.118521194522392 0.929080075570411 0.714285714285714 15.3 15 3 enlarged stomach 0.0329477009094409 0.118521194522392 0.929080075570411 0.714285714285714 15.3 15 3 increased stomach tumor incidence 0.0329477009094409 0.118521194522392 0.929080075570411 0.714285714285714 15.3 15 3 pulmonary alveolar hemorrhage 0.0329477009094409 0.118521194522392 0.929080075570411 0.714285714285714 15.3 15 3 abnormal vitelline vein topology 0.0329477009094409 0.118521194522392 0.929080075570411 0.714285714285714 15.3 15 3 cochlear degeneration 0.133712372523829 0.317678630996204 0.929080075570411 0.714285714285714 15.3 15 3 broad head 0.133712372523829 0.317678630996204 0.929080075570411 0.714285714285714 15.3 15 3 absent hair follicles 0.133712372523829 0.317678630996204 0.929080075570411 0.714285714285714 15.3 15 3 small L4 dorsal root ganglion 0.133712372523829 0.317678630996204 0.929080075570411 0.714285714285714 15.3 15 3 skin photosensitivity 0.133712372523829 0.317678630996204 0.929080075570411 0.714285714285714 15.3 15 3 absent epidermis stratum corneum 0.133712372523829 0.317678630996204 0.929080075570411 0.714285714285714 15.3 15 3 abnormal circulating free fatty acids level 0.133712372523829 0.317678630996204 0.929080075570411 0.714285714285714 15.3 15 3 abnormal axial mesoderm 0.133712372523829 0.317678630996204 0.929080075570411 0.714285714285714 15.3 15 3 increased chemically-elicited antinociception 0.133712372523829 0.317678630996204 0.929080075570411 0.714285714285714 15.3 15 3 abnormal adrenal gland physiology 0.133712372523829 0.317678630996204 0.929080075570411 0.714285714285714 15.3 15 3 increased retinal ganglion cell number 0.133712372523829 0.317678630996204 0.929080075570411 0.714285714285714 15.3 15 3 absent tunnel of Corti 0.133712372523829 0.317678630996204 0.929080075570411 0.714285714285714 15.3 15 3 decreased lateral semicircular canal size 0.133712372523829 0.317678630996204 0.929080075570411 0.714285714285714 15.3 15 3 aorta coarctation 0.133712372523829 0.317678630996204 0.929080075570411 0.714285714285714 15.3 15 3 abnormal nephron morphology 0.133712372523829 0.317678630996204 0.929080075570411 0.714285714285714 15.3 15 3 increased ectoderm apoptosis 0.133712372523829 0.317678630996204 0.929080075570411 0.714285714285714 15.3 15 3 utricular macular degeneration 0.133712372523829 0.317678630996204 0.929080075570411 0.714285714285714 15.3 15 3 absent ulna 0.133712372523829 0.317678630996204 0.929080075570411 0.714285714285714 15.3 15 3 abnormal cochlear nerve compound action potential 0.133712372523829 0.317678630996204 0.929080075570411 0.714285714285714 15.3 15 3 abnormal negative T cell selection 0.133712372523829 0.317678630996204 0.929080075570411 0.714285714285714 15.3 15 3 decreased adrenocorticotropin level 0.133712372523829 0.317678630996204 0.929080075570411 0.714285714285714 15.3 15 3 urolithiasis 0.133712372523829 0.317678630996204 0.929080075570411 0.714285714285714 15.3 15 3 absent fibula 0.133712372523829 0.317678630996204 0.929080075570411 0.714285714285714 15.3 15 3 abnormal renal/urinary system physiology 0.133712372523829 0.317678630996204 0.929080075570411 0.714285714285714 15.3 15 3 abnormal uterus physiology 0.133712372523829 0.317678630996204 0.929080075570411 0.714285714285714 15.3 15 3 heart hemorrhage 0.133712372523829 0.317678630996204 0.929080075570411 0.714285714285714 15.3 15 3 decreased behavioral withdrawal response 0.133712372523829 0.317678630996204 0.929080075570411 0.714285714285714 15.3 15 3 abnormal cerebellum white matter morphology 0.133712372523829 0.317678630996204 0.929080075570411 0.714285714285714 15.3 15 3 focal dorsal hair loss 0.133712372523829 0.317678630996204 0.929080075570411 0.714285714285714 15.3 15 3 thick pulmonary valve 0.133712372523829 0.317678630996204 0.929080075570411 0.714285714285714 15.3 15 3 thick mitral valve cusps 0.133712372523829 0.317678630996204 0.929080075570411 0.714285714285714 15.3 15 3 increased right ventricle systolic pressure 0.133712372523829 0.317678630996204 0.929080075570411 0.714285714285714 15.3 15 3 small lung saccule 0.133712372523829 0.317678630996204 0.929080075570411 0.714285714285714 15.3 15 3 dilated pulmonary alveolar ducts 0.133712372523829 0.317678630996204 0.929080075570411 0.714285714285714 15.3 15 3 increased compact bone volume 0.133712372523829 0.317678630996204 0.929080075570411 0.714285714285714 15.3 15 3 abnormal outer hair cell kinocilium morphology 0.133712372523829 0.317678630996204 0.929080075570411 0.714285714285714 15.3 15 3 abnormal brain ependyma motile cilium physiology 0.133712372523829 0.317678630996204 0.929080075570411 0.714285714285714 15.3 15 3 embryonic lethality at implantation, incomplete penetrance 0.133712372523829 0.317678630996204 0.929080075570411 0.714285714285714 15.3 15 3 small tail bud 0.133712372523829 0.317678630996204 0.929080075570411 0.714285714285714 15.3 15 3 absent heart tube 0.133712372523829 0.317678630996204 0.929080075570411 0.714285714285714 15.3 15 3 decreased areal bone mineral density 0.133712372523829 0.317678630996204 0.929080075570411 0.714285714285714 15.3 15 3 decreased femur compact bone thickness 0.133712372523829 0.317678630996204 0.929080075570411 0.714285714285714 15.3 15 3 ductus venosus stenosis 0.133712372523829 0.317678630996204 0.929080075570411 0.714285714285714 15.3 15 3 decreased collagen level 0.133712372523829 0.317678630996204 0.929080075570411 0.714285714285714 15.3 15 3 abnormal salivary gland morphology 0.0090180464136353 0.0435157913752043 0.929080075570411 0.714285714285714 15.3 15 3 abnormal eye pigmentation 0.0090180464136353 0.0435157913752043 0.929080075570411 0.714285714285714 15.3 15 3 trunk curl 0.0090180464136353 0.0435157913752043 0.929080075570411 0.714285714285714 15.3 15 3 abnormal hematopoietic system physiology 0.0090180464136353 0.0435157913752043 0.929080075570411 0.714285714285714 15.3 15 3 abnormal associative learning 0.0090180464136353 0.0435157913752043 0.929080075570411 0.714285714285714 15.3 15 3 abnormal stapes morphology 0.0090180464136353 0.0435157913752043 0.929080075570411 0.714285714285714 15.3 15 3 abnormal clavicle morphology 0.0090180464136353 0.0435157913752043 0.929080075570411 0.714285714285714 15.3 15 3 increased insulin sensitivity 1.34365341395744e-11 6.13273003159473e-10 0.927780662877306 0.713286713286713 15.3 15 3 abnormal testis morphology 1.35738695146958e-09 4.41372554481122e-08 0.927464284134637 0.71304347826087 15.3 15 3 decreased bone marrow cell number 1.44333699518801e-06 2.61112783674923e-05 0.926534650705835 0.712328767123288 15.3 15 3 increased hemoglobin content 1.51003591514859e-05 0.000212816676426749 0.925930651585427 0.711864406779661 15.3 15 3 decreased cardiac muscle contractility 9.90150577090482e-09 2.63422412889045e-07 0.925506690664371 0.711538461538462 15.3 15 3 reduced female fertility 1.18167179676612e-17 1.27800373671988e-15 0.925075420072263 0.711206896551724 15.3 15 3 abnormal cartilage development 0.000161876359738017 0.00171347848871624 0.924950830790098 0.711111111111111 15.3 15 3 irregular heartbeat 0.000161876359738017 0.00171347848871624 0.924950830790098 0.711111111111111 15.3 15 3 incomplete somite formation 0.000537599077771776 0.00474211952467125 0.92419018043583 0.710526315789474 15.3 15 3 abnormal retinal outer nuclear layer morphology 0.000537599077771776 0.00474211952467125 0.92419018043583 0.710526315789474 15.3 15 3 postnatal lethality, complete penetrance 3.90220690854521e-28 1.07852663166736e-25 0.923303411888108 0.709844559585492 15.3 15 3 prenatal lethality 1.07891223868582e-05 0.000155582272100346 0.923086010566731 0.709677419354839 15.3 15 3 osteopetrosis 0.00181148753367365 0.0122781341689733 0.923086010566731 0.709677419354839 15.3 15 3 decreased thymus weight 0.00181148753367365 0.0122781341689733 0.923086010566731 0.709677419354839 15.3 15 3 abnormal podocyte morphology 0.00181148753367365 0.0122781341689733 0.923086010566731 0.709677419354839 15.3 15 3 preaxial polydactyly 0.00181148753367365 0.0122781341689733 0.923086010566731 0.709677419354839 15.3 15 3 abnormal platelet physiology 3.50894586664383e-05 0.000449922826973017 0.922323129566263 0.709090909090909 15.3 15 3 abnormal nervous system morphology 7.42378076430476e-07 1.39898898872789e-05 0.92202377119899 0.708860759493671 15.3 15 3 overriding aortic valve 0.000114907231395034 0.00124005092449087 0.921337741607325 0.708333333333333 15.3 15 3 oligodactyly 0.000114907231395034 0.00124005092449087 0.921337741607325 0.708333333333333 15.3 15 3 thymus atrophy 0.000114907231395034 0.00124005092449087 0.921337741607325 0.708333333333333 15.3 15 3 abnormal digestive system morphology 0.00623765001774746 0.033083484902232 0.921337741607325 0.708333333333333 15.3 15 3 abnormal foregut morphology 0.00623765001774746 0.033083484902232 0.921337741607325 0.708333333333333 15.3 15 3 abnormal body weight 0.00623765001774746 0.033083484902232 0.921337741607325 0.708333333333333 15.3 15 3 apnea 0.00623765001774746 0.033083484902232 0.921337741607325 0.708333333333333 15.3 15 3 abnormal osteoblast morphology 0.00623765001774746 0.033083484902232 0.921337741607325 0.708333333333333 15.3 15 3 abnormal developmental patterning 5.32043811073164e-07 1.04209368507441e-05 0.920015879711188 0.707317073170732 15.3 15 3 abnormal spermiogenesis 2.49935879972611e-05 0.000336062433206416 0.919468902374855 0.706896551724138 15.3 15 3 abnormal neurocranium morphology 1.7079165827206e-06 3.00796905366173e-05 0.91916988809766 0.706666666666667 15.3 15 3 hemorrhage 2.7352880450287e-17 2.66824667137603e-15 0.91880089175559 0.706382978723404 15.3 15 3 cardiac fibrosis 3.81156586294283e-07 7.83576040005809e-06 0.918149721740171 0.705882352941177 15.3 15 3 abnormal adipose tissue morphology 0.0222595215426142 0.0867877113436565 0.918149721740171 0.705882352941177 15.3 15 3 abnormal urinary bladder morphology 0.0222595215426142 0.0867877113436565 0.918149721740171 0.705882352941177 15.3 15 3 hyperlipidemia 0.0222595215426142 0.0867877113436565 0.918149721740171 0.705882352941177 15.3 15 3 abnormal heart rate 0.0222595215426142 0.0867877113436565 0.918149721740171 0.705882352941177 15.3 15 3 decreased vasoconstriction 0.0222595215426142 0.0867877113436565 0.918149721740171 0.705882352941177 15.3 15 3 abnormal testis development 0.0222595215426142 0.0867877113436565 0.918149721740171 0.705882352941177 15.3 15 3 abnormal ectoplacental cone morphology 0.0222595215426142 0.0867877113436565 0.918149721740171 0.705882352941177 15.3 15 3 increased circulating magnesium level 0.0222595215426142 0.0867877113436565 0.918149721740171 0.705882352941177 15.3 15 3 decreased circulating cholesterol level 1.17181273372728e-13 6.94020041701571e-12 0.916895418841619 0.704918032786885 15.3 15 3 increased osteoclast cell number 1.77992473077032e-05 0.000245294336165716 0.916895418841619 0.704918032786885 15.3 15 3 small kidney 2.72970764188441e-07 5.90447631233693e-06 0.916410801812633 0.704545454545455 15.3 15 3 cochlear hair cell degeneration 0.000268277015054888 0.00261189461819583 0.916410801812633 0.704545454545455 15.3 15 3 atelectasis 3.92720770879986e-06 6.38492102982983e-05 0.915994440703222 0.704225352112676 15.3 15 3 increased circulating free fatty acid level 3.92720770879986e-06 6.38492102982983e-05 0.915994440703222 0.704225352112676 15.3 15 3 short snout 1.38191549972417e-08 3.58074458912903e-07 0.915315926302701 0.703703703703704 15.3 15 3 abnormal mandible morphology 5.78954998397291e-05 0.000682535809721925 0.915315926302701 0.703703703703704 15.3 15 3 rectal prolapse 0.00432702101732718 0.0246585676531532 0.915315926302701 0.703703703703704 15.3 15 3 abnormal brain commissure morphology 0.00432702101732718 0.0246585676531532 0.915315926302701 0.703703703703704 15.3 15 3 abnormal skin appearance 0.00432702101732718 0.0246585676531532 0.915315926302701 0.703703703703704 15.3 15 3 abnormal blood vessel morphology 5.09154184048062e-11 2.09342319474306e-09 0.914983688216929 0.703448275862069 15.3 15 3 impaired skeletal muscle contractility 0.000891841107885404 0.00698725907359037 0.914013912182783 0.702702702702703 15.3 15 3 increased erythroid progenitor cell number 0.000891841107885404 0.00698725907359037 0.914013912182783 0.702702702702703 15.3 15 3 abnormal chromosome morphology 0.000891841107885404 0.00698725907359037 0.914013912182783 0.702702702702703 15.3 15 3 abnormal humerus morphology 0.000891841107885404 0.00698725907359037 0.914013912182783 0.702702702702703 15.3 15 3 decreased bone mineral content 5.16800833499158e-15 3.67297735236902e-13 0.912999843493231 0.701923076923077 15.3 15 3 reduced male fertility 4.39041046666691e-16 3.58070361830621e-14 0.911071474986668 0.700440528634361 15.3 15 3 decreased heart rate 7.16274388702565e-08 1.68884601127738e-06 0.910498474059003 0.7 15.3 15 3 increased circulating chloride level 0.00013408400299434 0.00143764636831215 0.910498474059003 0.7 15.3 15 3 domed cranium 6.42552270173931e-06 9.86635044480033e-05 0.910498474059003 0.7 15.3 15 3 muscular ventricular septal defect 2.91803371358821e-05 0.000380031877620454 0.910498474059003 0.7 15.3 15 3 abnormal heart tube morphology 0.00300928048125601 0.0185746530946013 0.910498474059003 0.7 15.3 15 3 delayed eyelid opening 0.00300928048125601 0.0185746530946013 0.910498474059003 0.7 15.3 15 3 disorganized myocardium 0.00300928048125601 0.0185746530946013 0.910498474059003 0.7 15.3 15 3 abnormal microglial cell physiology 0.00300928048125601 0.0185746530946013 0.910498474059003 0.7 15.3 15 3 liver hemorrhage 0.00300928048125601 0.0185746530946013 0.910498474059003 0.7 15.3 15 3 abnormal brain vasculature morphology 0.00300928048125601 0.0185746530946013 0.910498474059003 0.7 15.3 15 3 abnormal cellular respiration 0.00300928048125601 0.0185746530946013 0.910498474059003 0.7 15.3 15 3 thin ventricular wall 3.18924089995819e-07 6.63869183150293e-06 0.910498474059003 0.7 15.3 15 3 abnormal circulating enzyme level 0.0151567474807357 0.0649926786499296 0.910498474059003 0.7 15.3 15 3 abnormal trachea morphology 0.0151567474807357 0.0649926786499296 0.910498474059003 0.7 15.3 15 3 decreased myocardial infarction size 0.0151567474807357 0.0649926786499296 0.910498474059003 0.7 15.3 15 3 abnormal hyoid bone morphology 0.0151567474807357 0.0649926786499296 0.910498474059003 0.7 15.3 15 3 abnormal induced retinal neovascularization 0.0151567474807357 0.0649926786499296 0.910498474059003 0.7 15.3 15 3 enhanced behavioral response to xenobiotic 0.0151567474807357 0.0649926786499296 0.910498474059003 0.7 15.3 15 3 abnormal neuron proliferation 0.0151567474807357 0.0649926786499296 0.910498474059003 0.7 15.3 15 3 absent ductus venosus valve 0.0151567474807357 0.0649926786499296 0.910498474059003 0.7 15.3 15 3 abnormal lateral semicircular canal morphology 0.0852083876789267 0.224648504876873 0.910498474059003 0.7 15.3 15 3 abnormal otic capsule morphology 0.0852083876789267 0.224648504876873 0.910498474059003 0.7 15.3 15 3 retarded hair growth 0.0852083876789267 0.224648504876873 0.910498474059003 0.7 15.3 15 3 abnormal optic nerve innervation 0.0852083876789267 0.224648504876873 0.910498474059003 0.7 15.3 15 3 abnormal immune cell physiology 0.0852083876789267 0.224648504876873 0.910498474059003 0.7 15.3 15 3 impaired social transmission of food preference 0.0852083876789267 0.224648504876873 0.910498474059003 0.7 15.3 15 3 abnormal primordial germ cell migration 0.0852083876789267 0.224648504876873 0.910498474059003 0.7 15.3 15 3 primary sex reversal 0.0852083876789267 0.224648504876873 0.910498474059003 0.7 15.3 15 3 abnormal bone healing 0.0852083876789267 0.224648504876873 0.910498474059003 0.7 15.3 15 3 abnormal scala media morphology 0.0852083876789267 0.224648504876873 0.910498474059003 0.7 15.3 15 3 aneurysm 0.0852083876789267 0.224648504876873 0.910498474059003 0.7 15.3 15 3 cochlear ganglion hypoplasia 0.0852083876789267 0.224648504876873 0.910498474059003 0.7 15.3 15 3 absent seminal vesicle 0.0852083876789267 0.224648504876873 0.910498474059003 0.7 15.3 15 3 absent CD4-positive, alpha beta T cells 0.0852083876789267 0.224648504876873 0.910498474059003 0.7 15.3 15 3 abnormal gas homeostasis 0.0852083876789267 0.224648504876873 0.910498474059003 0.7 15.3 15 3 abnormal utricular macula morphology 0.0852083876789267 0.224648504876873 0.910498474059003 0.7 15.3 15 3 tachypnea 0.0852083876789267 0.224648504876873 0.910498474059003 0.7 15.3 15 3 ventricular premature beat 0.0852083876789267 0.224648504876873 0.910498474059003 0.7 15.3 15 3 impaired behavioral response to morphine 0.0852083876789267 0.224648504876873 0.910498474059003 0.7 15.3 15 3 increased circulating fructosamine level 0.0852083876789267 0.224648504876873 0.910498474059003 0.7 15.3 15 3 increased kidney iron level 0.0852083876789267 0.224648504876873 0.910498474059003 0.7 15.3 15 3 abnormal heart and great artery attachment 0.0852083876789267 0.224648504876873 0.910498474059003 0.7 15.3 15 3 decreased trabecular bone connectivity density 0.0852083876789267 0.224648504876873 0.910498474059003 0.7 15.3 15 3 decreased susceptibility to hepatic steatosis 2.07209153737933e-05 0.000281657251324103 0.908433851668846 0.698412698412698 15.3 15 3 extramedullary hematopoiesis 3.66509760081504e-08 9.11693028202741e-07 0.908044300274477 0.69811320754717 15.3 15 3 abnormal placenta development 9.48528918265751e-05 0.0010486514151938 0.908044300274477 0.69811320754717 15.3 15 3 increased oxygen consumption 7.26284283997923e-07 1.37386475775273e-05 0.907473562185053 0.697674418604651 15.3 15 3 impaired glucose tolerance 4.33146841198998e-17 4.14404910570195e-15 0.907351589932071 0.69758064516129 15.3 15 3 abnormal skeleton physiology 0.00209752530016384 0.0140257908176278 0.90655692222325 0.696969696969697 15.3 15 3 dilated heart atrium 0.00209752530016384 0.0140257908176278 0.90655692222325 0.696969696969697 15.3 15 3 abnormal visceral yolk sac morphology 2.31965551225917e-06 3.97940902534117e-05 0.905559060999008 0.69620253164557 15.3 15 3 abnormal sternum morphology 1.04538665161014e-05 0.000151186005574431 0.904843204033792 0.695652173913043 15.3 15 3 microcephaly 1.04538665161014e-05 0.000151186005574431 0.904843204033792 0.695652173913043 15.3 15 3 abnormal sleep pattern 0.000310411410749303 0.00295644850447302 0.904843204033792 0.695652173913043 15.3 15 3 fragile skeleton 0.010383021482769 0.0496210680852794 0.904843204033792 0.695652173913043 15.3 15 3 abnormal pulmonary artery morphology 0.010383021482769 0.0496210680852794 0.904843204033792 0.695652173913043 15.3 15 3 abnormal innervation pattern to muscle 0.010383021482769 0.0496210680852794 0.904843204033792 0.695652173913043 15.3 15 3 increased susceptibility to age related obesity 0.010383021482769 0.0496210680852794 0.904843204033792 0.695652173913043 15.3 15 3 abnormal Wolffian duct morphology 0.010383021482769 0.0496210680852794 0.904843204033792 0.695652173913043 15.3 15 3 abnormal B cell morphology 0.010383021482769 0.0496210680852794 0.904843204033792 0.695652173913043 15.3 15 3 decreased lymphocyte cell number 2.17183753499516e-09 6.54841923430359e-08 0.904401386063072 0.6953125 15.3 15 3 syndactyly 4.75281648126383e-05 0.000569765349259941 0.903884683690536 0.694915254237288 15.3 15 3 decreased erythrocyte cell number 4.12246872253083e-11 1.73807473682974e-09 0.903042162624489 0.694267515923567 15.3 15 3 abnormal bone mineralization 6.85069864136186e-09 1.93649009890768e-07 0.902973693281656 0.694214876033058 15.3 15 3 abnormal long bone hypertrophic chondrocyte zone 0.000218740766985078 0.00218960828118866 0.902534930554114 0.693877551020408 15.3 15 3 increased sarcoma incidence 0.000218740766985078 0.00218960828118866 0.902534930554114 0.693877551020408 15.3 15 3 increased fluid intake 0.000218740766985078 0.00218960828118866 0.902534930554114 0.693877551020408 15.3 15 3 increased circulating insulin level 2.95200484481558e-11 1.31127000919263e-09 0.902369023397762 0.69375 15.3 15 3 abnormal cornea morphology 3.75142956024809e-06 6.24192711111514e-05 0.900492996322091 0.692307692307692 15.3 15 3 abnormal snout morphology 0.00015426460033965 0.00164339697363974 0.900492996322091 0.692307692307692 15.3 15 3 failure of heart looping 0.00102485871490612 0.00791719271220181 0.900492996322091 0.692307692307692 15.3 15 3 abnormal circulating hormone level 0.00102485871490612 0.00791719271220181 0.900492996322091 0.692307692307692 15.3 15 3 no spontaneous movement 0.00714720721513473 0.0358802784009034 0.900492996322091 0.692307692307692 15.3 15 3 increased susceptibility to otitis media 0.00714720721513473 0.0358802784009034 0.900492996322091 0.692307692307692 15.3 15 3 absent teeth 0.0558046470241478 0.176608218158483 0.900492996322091 0.692307692307692 15.3 15 3 absent common myeloid progenitor cells 0.0558046470241478 0.176608218158483 0.900492996322091 0.692307692307692 15.3 15 3 small trigeminal ganglion 0.0558046470241478 0.176608218158483 0.900492996322091 0.692307692307692 15.3 15 3 lymphoid hypoplasia 0.0558046470241478 0.176608218158483 0.900492996322091 0.692307692307692 15.3 15 3 abnormal lung interstitium morphology 0.0558046470241478 0.176608218158483 0.900492996322091 0.692307692307692 15.3 15 3 tracheoesophageal fistula 0.0558046470241478 0.176608218158483 0.900492996322091 0.692307692307692 15.3 15 3 abnormal vestibulocochlear ganglion morphology 0.0558046470241478 0.176608218158483 0.900492996322091 0.692307692307692 15.3 15 3 small otic vesicle 0.0558046470241478 0.176608218158483 0.900492996322091 0.692307692307692 15.3 15 3 decreased luteinizing hormone level 0.0558046470241478 0.176608218158483 0.900492996322091 0.692307692307692 15.3 15 3 small pituitary gland 0.0558046470241478 0.176608218158483 0.900492996322091 0.692307692307692 15.3 15 3 abnormal seminiferous tubule morphology 2.90978106827355e-10 1.05665407406284e-08 0.899807689627782 0.691780821917808 15.3 15 3 increased exploration in new environment 2.66687325992702e-06 4.52822336796482e-05 0.89925775215704 0.691358024691358 15.3 15 3 abnormal skeleton development 2.66687325992702e-06 4.52822336796482e-05 0.89925775215704 0.691358024691358 15.3 15 3 decreased heart weight 2.66687325992702e-06 4.52822336796482e-05 0.89925775215704 0.691358024691358 15.3 15 3 abnormal joint morphology 0.000108873709521204 0.00119043231839118 0.898673818551743 0.690909090909091 15.3 15 3 abnormal myocardial fiber morphology 3.02837676235472e-07 6.41113803945309e-06 0.898430011221697 0.690721649484536 15.3 15 3 increased heart weight 9.13513707718412e-10 3.02982046393273e-08 0.898333540695419 0.690647482014389 15.3 15 3 arrest of spermatogenesis 1.89621962617184e-06 3.32172276063553e-05 0.898110739718064 0.69047619047619 15.3 15 3 abnormal optic nerve morphology 0.000718115167468146 0.00590516191430418 0.898110739718064 0.69047619047619 15.3 15 3 skin edema 0.000718115167468146 0.00590516191430418 0.898110739718064 0.69047619047619 15.3 15 3 abnormal pancreas morphology 0.000718115167468146 0.00590516191430418 0.898110739718064 0.69047619047619 15.3 15 3 abnormal spermatogenesis 2.03382147364594e-12 9.91986454057699e-11 0.897774116502278 0.690217391304348 15.3 15 3 abnormal parietal bone morphology 0.00493923606127296 0.0275787872108114 0.897042831585225 0.689655172413793 15.3 15 3 aphagia 0.00493923606127296 0.0275787872108114 0.897042831585225 0.689655172413793 15.3 15 3 decreased trophoblast giant cell number 0.00493923606127296 0.0275787872108114 0.897042831585225 0.689655172413793 15.3 15 3 short sternum 0.00493923606127296 0.0275787872108114 0.897042831585225 0.689655172413793 15.3 15 3 abnormal intestine morphology 8.50499310487303e-06 0.000127064086176406 0.896436721563883 0.689189189189189 15.3 15 3 small seminiferous tubules 8.50499310487303e-06 0.000127064086176406 0.896436721563883 0.689189189189189 15.3 15 3 oxidative stress 9.59168315095154e-07 1.79393322090165e-05 0.896046117327908 0.688888888888889 15.3 15 3 abnormal ovarian follicle morphology 0.000503878466113673 0.00451172222659434 0.896046117327908 0.688888888888889 15.3 15 3 albuminuria 0.000503878466113673 0.00451172222659434 0.896046117327908 0.688888888888889 15.3 15 3 increased or absent threshold for auditory brainstem response 1.94725268154742e-18 2.36282490017034e-16 0.895646052089677 0.688581314878893 15.3 15 3 abnormal long bone morphology 5.43385357034358e-05 0.000643652893153793 0.895572269566232 0.688524590163934 15.3 15 3 abnormal definitive hematopoiesis 6.82354303646443e-07 1.30565871563117e-05 0.895113707216224 0.688172043010753 15.3 15 3 decreased hemoglobin content 1.04437474468149e-09 3.44090354621881e-08 0.894816129521006 0.687943262411348 15.3 15 3 abnormal phalanx morphology 0.000353995380637038 0.00330417827142451 0.894239572736521 0.6875 15.3 15 3 decreased circulating LDL cholesterol level 3.8423388246227e-05 0.000480292353077837 0.894239572736521 0.6875 15.3 15 3 increased dopamine level 0.00342457992492342 0.0201624676053184 0.894239572736521 0.6875 15.3 15 3 abnormal diaphragm morphology 0.00342457992492342 0.0201624676053184 0.894239572736521 0.6875 15.3 15 3 abnormal heart atrium morphology 0.00342457992492342 0.0201624676053184 0.894239572736521 0.6875 15.3 15 3 abnormal embryonic hematopoiesis 0.00342457992492342 0.0201624676053184 0.894239572736521 0.6875 15.3 15 3 increased fatty acid level 0.00342457992492342 0.0201624676053184 0.894239572736521 0.6875 15.3 15 3 abnormal serotonin level 0.00342457992492342 0.0201624676053184 0.894239572736521 0.6875 15.3 15 3 abnormal bone marrow cell number 0.0371700254824561 0.125370085949301 0.894239572736521 0.6875 15.3 15 3 disorganized retinal layers 0.0371700254824561 0.125370085949301 0.894239572736521 0.6875 15.3 15 3 reduced male mating frequency 0.0371700254824561 0.125370085949301 0.894239572736521 0.6875 15.3 15 3 poor circulation 0.0371700254824561 0.125370085949301 0.894239572736521 0.6875 15.3 15 3 disorganized yolk sac vascular plexus 0.0371700254824561 0.125370085949301 0.894239572736521 0.6875 15.3 15 3 abnormal extraembryonic endoderm formation 0.0371700254824561 0.125370085949301 0.894239572736521 0.6875 15.3 15 3 abnormal olfaction 0.0371700254824561 0.125370085949301 0.894239572736521 0.6875 15.3 15 3 abnormal epicardium morphology 0.0371700254824561 0.125370085949301 0.894239572736521 0.6875 15.3 15 3 decreased cochlear coiling 0.0371700254824561 0.125370085949301 0.894239572736521 0.6875 15.3 15 3 impaired muscle relaxation 0.0371700254824561 0.125370085949301 0.894239572736521 0.6875 15.3 15 3 bowed tibia 0.0371700254824561 0.125370085949301 0.894239572736521 0.6875 15.3 15 3 bowed radius 0.0371700254824561 0.125370085949301 0.894239572736521 0.6875 15.3 15 3 decreased circulating growth hormone level 0.0371700254824561 0.125370085949301 0.894239572736521 0.6875 15.3 15 3 decreased circulating prolactin level 0.0371700254824561 0.125370085949301 0.894239572736521 0.6875 15.3 15 3 kidney degeneration 0.0371700254824561 0.125370085949301 0.894239572736521 0.6875 15.3 15 3 abnormal thoracic cage shape 0.0371700254824561 0.125370085949301 0.894239572736521 0.6875 15.3 15 3 embryonic lethality between somite formation and embryo turning, incomplete penetrance 0.0371700254824561 0.125370085949301 0.894239572736521 0.6875 15.3 15 3 rib fusion 2.71845777219911e-05 0.000361613032531833 0.89302622189156 0.686567164179104 15.3 15 3 internal hemorrhage 2.71845777219911e-05 0.000361613032531833 0.89302622189156 0.686567164179104 15.3 15 3 impaired hematopoiesis 0.00024897537018117 0.00244792977599076 0.892645562802944 0.686274509803922 15.3 15 3 abnormal gluconeogenesis 0.00024897537018117 0.00244792977599076 0.892645562802944 0.686274509803922 15.3 15 3 failure of chorioallantoic fusion 0.00024897537018117 0.00244792977599076 0.892645562802944 0.686274509803922 15.3 15 3 abnormal retina morphology 1.58808724650805e-13 9.08130350733049e-12 0.891916872547595 0.685714285714286 15.3 15 3 abnormal dermal layer morphology 0.0023809976362906 0.0155861358428234 0.891916872547595 0.685714285714286 15.3 15 3 abnormal embryonic epiblast morphology 0.0023809976362906 0.0155861358428234 0.891916872547595 0.685714285714286 15.3 15 3 decreased bone volume 0.0023809976362906 0.0155861358428234 0.891916872547595 0.685714285714286 15.3 15 3 anophthalmia 1.53439884840608e-06 2.76580951841314e-05 0.891499308468687 0.685393258426966 15.3 15 3 abnormal cochlea morphology 0.000175289568503827 0.00180178843658375 0.891228665084209 0.685185185185185 15.3 15 3 diluted coat color 0.000175289568503827 0.00180178843658375 0.891228665084209 0.685185185185185 15.3 15 3 abnormal maxilla morphology 0.000175289568503827 0.00180178843658375 0.891228665084209 0.685185185185185 15.3 15 3 abnormal long bone epiphyseal plate proliferative zone 0.000175289568503827 0.00180178843658375 0.891228665084209 0.685185185185185 15.3 15 3 decreased hematocrit 8.48200211751914e-10 2.84465273620924e-08 0.890898702601764 0.684931506849315 15.3 15 3 hyporesponsive to tactile stimuli 0.00165936550646492 0.0115945834194705 0.889960914493762 0.684210526315789 15.3 15 3 abnormal triglyceride level 0.0250460065552185 0.0965921570637301 0.889960914493762 0.684210526315789 15.3 15 3 decreased grooming behavior 0.0250460065552185 0.0965921570637301 0.889960914493762 0.684210526315789 15.3 15 3 abnormal neurotransmitter level 0.0250460065552185 0.0965921570637301 0.889960914493762 0.684210526315789 15.3 15 3 abnormal photoreceptor inner segment morphology 0.0250460065552185 0.0965921570637301 0.889960914493762 0.684210526315789 15.3 15 3 abnormal sternebra morphology 0.0250460065552185 0.0965921570637301 0.889960914493762 0.684210526315789 15.3 15 3 absent amnion 0.0250460065552185 0.0965921570637301 0.889960914493762 0.684210526315789 15.3 15 3 decreased eye pigmentation 0.0250460065552185 0.0965921570637301 0.889960914493762 0.684210526315789 15.3 15 3 increased liver cholesterol level 0.0250460065552185 0.0965921570637301 0.889960914493762 0.684210526315789 15.3 15 3 shortened RR interval 0.0250460065552185 0.0965921570637301 0.889960914493762 0.684210526315789 15.3 15 3 abnormal cardiovascular system physiology 5.20675761392299e-09 1.50602436798063e-07 0.889960914493762 0.684210526315789 15.3 15 3 polydactyly 5.50871378065105e-07 1.07473925720545e-05 0.889262358045965 0.683673469387755 15.3 15 3 abnormal somite development 6.84406150390412e-06 0.000103808554822936 0.889094350799026 0.683544303797468 15.3 15 3 abnormal long bone epiphyseal plate morphology 8.71208455887946e-05 0.000973991475964613 0.88881993896236 0.683333333333333 15.3 15 3 increased erythrocyte cell number 8.71208455887946e-05 0.000973991475964613 0.88881993896236 0.683333333333333 15.3 15 3 abnormal pulmonary alveolus morphology 3.91692688872328e-07 7.9885371257709e-06 0.888605300001007 0.683168316831683 15.3 15 3 arrested B cell differentiation 0.00115882643197105 0.00884227223781594 0.888291194203905 0.682926829268293 15.3 15 3 cachexia 2.7856595055783e-07 5.94792104731847e-06 0.887986149150951 0.682692307692308 15.3 15 3 infertility 1.98149647587813e-07 4.44051575112329e-06 0.88740171704015 0.682242990654206 15.3 15 3 hypertension 0.000810728741991457 0.00644309183930911 0.886849163044483 0.681818181818182 15.3 15 3 decreased blood urea nitrogen level 0.000810728741991457 0.00644309183930911 0.886849163044483 0.681818181818182 15.3 15 3 embryonic lethality, incomplete penetrance 0.000810728741991457 0.00644309183930911 0.886849163044483 0.681818181818182 15.3 15 3 abnormal abdominal fat pad morphology 0.017019922833373 0.0703857989160688 0.886849163044483 0.681818181818182 15.3 15 3 abnormal enterocyte morphology 0.017019922833373 0.0703857989160688 0.886849163044483 0.681818181818182 15.3 15 3 abnormal facial nerve morphology 0.017019922833373 0.0703857989160688 0.886849163044483 0.681818181818182 15.3 15 3 abnormal oogenesis 0.017019922833373 0.0703857989160688 0.886849163044483 0.681818181818182 15.3 15 3 testis hypoplasia 0.017019922833373 0.0703857989160688 0.886849163044483 0.681818181818182 15.3 15 3 abnormal blood-brain barrier function 0.017019922833373 0.0703857989160688 0.886849163044483 0.681818181818182 15.3 15 3 cleft upper lip 0.017019922833373 0.0703857989160688 0.886849163044483 0.681818181818182 15.3 15 3 abnormal sperm midpiece morphology 0.017019922833373 0.0703857989160688 0.886849163044483 0.681818181818182 15.3 15 3 pulmonary vascular congestion 0.017019922833373 0.0703857989160688 0.886849163044483 0.681818181818182 15.3 15 3 increased circulating creatine kinase level 0.017019922833373 0.0703857989160688 0.886849163044483 0.681818181818182 15.3 15 3 enlarged heart 2.70938513750382e-14 1.72810141783096e-12 0.885829796190409 0.681034482758621 15.3 15 3 abnormal innervation 0.000568094893877079 0.00486449586409375 0.885591220969243 0.680851063829787 15.3 15 3 increased respiratory quotient 0.000568094893877079 0.00486449586409375 0.885591220969243 0.680851063829787 15.3 15 3 decreased bone trabecula number 0.000568094893877079 0.00486449586409375 0.885591220969243 0.680851063829787 15.3 15 3 abnormal digit morphology 2.17102912847437e-05 0.000294301632538419 0.885206849779586 0.680555555555556 15.3 15 3 abnormal hindlimb morphology 0.000398636390465398 0.00364561772530396 0.884484231943032 0.68 15.3 15 3 decreased circulating alkaline phosphatase level 0.000398636390465398 0.00364561772530396 0.884484231943032 0.68 15.3 15 3 abnormal inner ear vestibule morphology 0.0116409399565353 0.0538731872407098 0.884484231943032 0.68 15.3 15 3 abnormal primitive streak morphology 0.0116409399565353 0.0538731872407098 0.884484231943032 0.68 15.3 15 3 abnormal egg cylinder morphology 0.0116409399565353 0.0538731872407098 0.884484231943032 0.68 15.3 15 3 abnormal vertebrae development 0.0116409399565353 0.0538731872407098 0.884484231943032 0.68 15.3 15 3 abnormal preimplantation embryo development 0.0116409399565353 0.0538731872407098 0.884484231943032 0.68 15.3 15 3 abnormal kidney morphology 4.59742170776137e-11 1.90601441634273e-09 0.884484231943031 0.68 15.3 15 3 abnormal vertebrae morphology 2.23061924524639e-07 4.91032333854018e-06 0.883052255312795 0.678899082568807 15.3 15 3 abnormal coat/hair pigmentation 1.58615037560451e-07 3.58686278119656e-06 0.882626071791891 0.678571428571429 15.3 15 3 failure of blastocyst to hatch from the zona pellucida 0.00800282260464569 0.0395372814876984 0.882626071791891 0.678571428571429 15.3 15 3 abnormal renal tubule epithelium morphology 0.00800282260464569 0.0395372814876984 0.882626071791891 0.678571428571429 15.3 15 3 lethargy 1.9469495459199e-06 3.38673915767536e-05 0.881127555540971 0.67741935483871 15.3 15 3 increased lung adenoma incidence 0.00552464567117896 0.0303367684482509 0.881127555540971 0.67741935483871 15.3 15 3 abnormal retinal photoreceptor layer morphology 0.00552464567117896 0.0303367684482509 0.881127555540971 0.67741935483871 15.3 15 3 small cranium 0.00552464567117896 0.0303367684482509 0.881127555540971 0.67741935483871 15.3 15 3 enlarged spleen 7.07282773032909e-17 6.51616999229393e-15 0.880690488301119 0.677083333333333 15.3 15 3 deafness 9.80862577159488e-07 1.8276371990144e-05 0.880279909984895 0.676767676767677 15.3 15 3 lung hemorrhage 0.00382703094239942 0.0222683964192247 0.879893483334331 0.676470588235294 15.3 15 3 abnormal endoderm development 0.00382703094239942 0.0222683964192247 0.879893483334331 0.676470588235294 15.3 15 3 abnormal vision 0.00382703094239942 0.0222683964192247 0.879893483334331 0.676470588235294 15.3 15 3 abnormal spleen red pulp morphology 0.00382703094239942 0.0222683964192247 0.879893483334331 0.676470588235294 15.3 15 3 abnormal skeletal muscle fiber morphology 3.43797359309608e-05 0.000441961721593101 0.879354663075093 0.676056338028169 15.3 15 3 abnormal liver morphology 5.79140880665935e-11 2.3616605584533e-09 0.879252317327529 0.675977653631285 15.3 15 3 abnormal respiratory electron transport chain 0.00265876361431639 0.0171117063146495 0.878859530944984 0.675675675675676 15.3 15 3 abnormal left-right axis patterning 0.00129239776705105 0.00944152553756088 0.877224443445551 0.674418604651163 15.3 15 3 abnormal homeostasis 0.00129239776705105 0.00944152553756088 0.877224443445551 0.674418604651163 15.3 15 3 abnormal double-strand DNA break repair 0.00129239776705105 0.00944152553756088 0.877224443445551 0.674418604651163 15.3 15 3 increased circulating LDL cholesterol level 0.000632958021294201 0.00533993106378824 0.875989785537816 0.673469387755102 15.3 15 3 increased percent body fat/body weight 0.000443968131619597 0.00403055010001367 0.875479301979811 0.673076923076923 15.3 15 3 increased circulating alkaline phosphatase level 7.71497443653211e-10 2.61102025998281e-08 0.875170490938548 0.672839506172839 15.3 15 3 increased sensitivity to xenobiotic induced morbidity/mortality 3.91799609786552e-07 7.9885371257709e-06 0.875024507537224 0.672727272727273 15.3 15 3 abnormal B cell differentiation 4.79888691098345e-06 7.70143947811054e-05 0.871905917073771 0.67032967032967 15.3 15 3 decreased double-positive T cell number 1.71106581343974e-06 3.00796905366173e-05 0.871477110885046 0.67 15.3 15 3 male infertility 7.72909456089376e-27 1.74782933820211e-24 0.871451251797455 0.669980119284294 15.3 15 3 abnormal skeleton morphology 3.08775059365444e-07 6.50913525569104e-06 0.870911583882525 0.669565217391304 15.3 15 3 small testis 5.3964497920117e-15 3.78131517116313e-13 0.867141403865717 0.666666666666667 15.3 15 3 insulin resistance 6.19227350237379e-08 1.5027590572834e-06 0.867141403865717 0.666666666666667 15.3 15 3 increased rib number 2.98083568757601e-05 0.000387197324952758 0.867141403865717 0.666666666666667 15.3 15 3 cochlear outer hair cell degeneration 5.97186252233958e-05 0.000702364445594312 0.867141403865717 0.666666666666667 15.3 15 3 cochlear inner hair cell degeneration 0.00069795843103385 0.0058358709149469 0.867141403865717 0.666666666666667 15.3 15 3 abnormal iris morphology 0.00292837908958253 0.0184341609005404 0.867141403865717 0.666666666666667 15.3 15 3 decreased trabecular bone volume 0.00292837908958253 0.0184341609005404 0.867141403865717 0.666666666666667 15.3 15 3 abnormal retinal blood vessel morphology 0.00421319879703767 0.0244296783394667 0.867141403865717 0.666666666666667 15.3 15 3 abnormal tooth development 0.00607868917444257 0.0324131603889087 0.867141403865717 0.666666666666667 15.3 15 3 abnormal aorta morphology 0.00607868917444257 0.0324131603889087 0.867141403865717 0.666666666666667 15.3 15 3 belly spot 0.00607868917444257 0.0324131603889087 0.867141403865717 0.666666666666667 15.3 15 3 abnormal ovarian folliculogenesis 0.00607868917444257 0.0324131603889087 0.867141403865717 0.666666666666667 15.3 15 3 myeloid hyperplasia 0.00607868917444257 0.0324131603889087 0.867141403865717 0.666666666666667 15.3 15 3 emphysema 0.00879914722130689 0.0427915517360721 0.867141403865717 0.666666666666667 15.3 15 3 abnormal megakaryocyte differentiation 0.0406173493551786 0.133858658050179 0.867141403865717 0.666666666666667 15.3 15 3 abnormal thyroid cartilage morphology 0.0406173493551786 0.133858658050179 0.867141403865717 0.666666666666667 15.3 15 3 absent allantois 0.0406173493551786 0.133858658050179 0.867141403865717 0.666666666666667 15.3 15 3 darkened coat color 0.0406173493551786 0.133858658050179 0.867141403865717 0.666666666666667 15.3 15 3 abnormal pregnancy 0.0406173493551786 0.133858658050179 0.867141403865717 0.666666666666667 15.3 15 3 increased gastrointestinal tumor incidence 0.0406173493551786 0.133858658050179 0.867141403865717 0.666666666666667 15.3 15 3 decreased tumor latency 0.0406173493551786 0.133858658050179 0.867141403865717 0.666666666666667 15.3 15 3 increased adipocyte glucose uptake 0.0406173493551786 0.133858658050179 0.867141403865717 0.666666666666667 15.3 15 3 interdigital webbing 0.0607594343877571 0.184879624513206 0.867141403865717 0.666666666666667 15.3 15 3 abnormal prostate gland morphology 0.0607594343877571 0.184879624513206 0.867141403865717 0.666666666666667 15.3 15 3 altered righting response 0.0607594343877571 0.184879624513206 0.867141403865717 0.666666666666667 15.3 15 3 abnormal energy homeostasis 0.0607594343877571 0.184879624513206 0.867141403865717 0.666666666666667 15.3 15 3 abnormal Muller cell morphology 0.0607594343877571 0.184879624513206 0.867141403865717 0.666666666666667 15.3 15 3 absent chorion 0.0607594343877571 0.184879624513206 0.867141403865717 0.666666666666667 15.3 15 3 bicuspid aortic valve 0.0607594343877571 0.184879624513206 0.867141403865717 0.666666666666667 15.3 15 3 decreased brown adipose tissue mass 0.0607594343877571 0.184879624513206 0.867141403865717 0.666666666666667 15.3 15 3 distorted hair follicle pattern 0.143068549996343 0.33353609945258 0.867141403865717 0.666666666666667 15.3 15 3 thick tail 0.143068549996343 0.33353609945258 0.867141403865717 0.666666666666667 15.3 15 3 absent parathyroid glands 0.143068549996343 0.33353609945258 0.867141403865717 0.666666666666667 15.3 15 3 abnormal sympathetic neuron morphology 0.143068549996343 0.33353609945258 0.867141403865717 0.666666666666667 15.3 15 3 small nodose ganglion 0.143068549996343 0.33353609945258 0.867141403865717 0.666666666666667 15.3 15 3 decreased level of surface class I molecules 0.143068549996343 0.33353609945258 0.867141403865717 0.666666666666667 15.3 15 3 genetic imprinting 0.143068549996343 0.33353609945258 0.867141403865717 0.666666666666667 15.3 15 3 abnormal abdominal wall morphology 0.143068549996343 0.33353609945258 0.867141403865717 0.666666666666667 15.3 15 3 impaired febrile response 0.143068549996343 0.33353609945258 0.867141403865717 0.666666666666667 15.3 15 3 abnormal proprioceptive neuron morphology 0.143068549996343 0.33353609945258 0.867141403865717 0.666666666666667 15.3 15 3 absent cochlear outer hair cells 0.143068549996343 0.33353609945258 0.867141403865717 0.666666666666667 15.3 15 3 abnormal posterior eye segment morphology 0.143068549996343 0.33353609945258 0.867141403865717 0.666666666666667 15.3 15 3 absent adrenal gland 0.143068549996343 0.33353609945258 0.867141403865717 0.666666666666667 15.3 15 3 positive geotaxis 0.143068549996343 0.33353609945258 0.867141403865717 0.666666666666667 15.3 15 3 abnormal leukopoiesis 0.143068549996343 0.33353609945258 0.867141403865717 0.666666666666667 15.3 15 3 increased tidal volume 0.143068549996343 0.33353609945258 0.867141403865717 0.666666666666667 15.3 15 3 multiflagellated sperm 0.143068549996343 0.33353609945258 0.867141403865717 0.666666666666667 15.3 15 3 axonal spheroids 0.143068549996343 0.33353609945258 0.867141403865717 0.666666666666667 15.3 15 3 iris coloboma 0.143068549996343 0.33353609945258 0.867141403865717 0.666666666666667 15.3 15 3 fusion of atlas and occipital bones 0.143068549996343 0.33353609945258 0.867141403865717 0.666666666666667 15.3 15 3 abnormal oxidative phosphorylation 0.143068549996343 0.33353609945258 0.867141403865717 0.666666666666667 15.3 15 3 abnormal lung lobe morphology 0.143068549996343 0.33353609945258 0.867141403865717 0.666666666666667 15.3 15 3 increased myeloid cell number 0.143068549996343 0.33353609945258 0.867141403865717 0.666666666666667 15.3 15 3 abnormal coronary sinus connection 0.143068549996343 0.33353609945258 0.867141403865717 0.666666666666667 15.3 15 3 symmetric azygos veins 0.143068549996343 0.33353609945258 0.867141403865717 0.666666666666667 15.3 15 3 decreased bone mineral density of femur 0.143068549996343 0.33353609945258 0.867141403865717 0.666666666666667 15.3 15 3 increased bone mineralization 0.143068549996343 0.33353609945258 0.867141403865717 0.666666666666667 15.3 15 3 increased endoplasmic reticulum stress 0.143068549996343 0.33353609945258 0.867141403865717 0.666666666666667 15.3 15 3 abnormal heart morphology 8.58677612628627e-13 4.49675907666044e-11 0.867141403865717 0.666666666666667 15.3 15 3 abnormal rib morphology 4.40478531109654e-08 1.09023915038335e-06 0.867141403865717 0.666666666666667 15.3 15 3 delayed bone ossification 4.21776342934476e-05 0.000514298359337995 0.867141403865717 0.666666666666667 15.3 15 3 decreased tumor growth/size 0.000489653753388488 0.0044051128808458 0.867141403865717 0.666666666666667 15.3 15 3 abnormal osteoclast morphology 0.000996293920357164 0.00772050195292351 0.867141403865717 0.666666666666667 15.3 15 3 abnormal cell migration 0.00142442929374704 0.0102111465942241 0.867141403865717 0.666666666666667 15.3 15 3 small placenta 0.00142442929374704 0.0102111465942241 0.867141403865717 0.666666666666667 15.3 15 3 abnormal metabolism 0.00142442929374704 0.0102111465942241 0.867141403865717 0.666666666666667 15.3 15 3 abnormal palate morphology 0.0127875796107498 0.0590150357731729 0.867141403865717 0.666666666666667 15.3 15 3 abnormal bone trabecula morphology 0.0127875796107498 0.0590150357731729 0.867141403865717 0.666666666666667 15.3 15 3 abnormal nursing 0.0186737644128122 0.076778494176645 0.867141403865717 0.666666666666667 15.3 15 3 abnormal sensory capabilities/reflexes/nociception 0.0186737644128122 0.076778494176645 0.867141403865717 0.666666666666667 15.3 15 3 abnormal primitive streak formation 0.0186737644128122 0.076778494176645 0.867141403865717 0.666666666666667 15.3 15 3 hypopigmentation 0.0186737644128122 0.076778494176645 0.867141403865717 0.666666666666667 15.3 15 3 abnormal esophagus morphology 0.0922170109707942 0.240198758942252 0.867141403865717 0.666666666666667 15.3 15 3 abnormal glossopharyngeal nerve morphology 0.0922170109707942 0.240198758942252 0.867141403865717 0.666666666666667 15.3 15 3 abnormal pilomotor reflex 0.0922170109707942 0.240198758942252 0.867141403865717 0.666666666666667 15.3 15 3 impaired embryo implantation 0.0922170109707942 0.240198758942252 0.867141403865717 0.666666666666667 15.3 15 3 ear inflammation 0.0922170109707942 0.240198758942252 0.867141403865717 0.666666666666667 15.3 15 3 interstitial pneumonia 0.0922170109707942 0.240198758942252 0.867141403865717 0.666666666666667 15.3 15 3 increased papilloma incidence 0.0922170109707942 0.240198758942252 0.867141403865717 0.666666666666667 15.3 15 3 abnormal tracheal ciliated epithelium morphology 0.0922170109707942 0.240198758942252 0.867141403865717 0.666666666666667 15.3 15 3 dilated bile duct 0.0922170109707942 0.240198758942252 0.867141403865717 0.666666666666667 15.3 15 3 delayed somite formation 0.0922170109707942 0.240198758942252 0.867141403865717 0.666666666666667 15.3 15 3 decreased left ventricle systolic pressure 0.0922170109707942 0.240198758942252 0.867141403865717 0.666666666666667 15.3 15 3 vestibular saccular macula degeneration 0.0922170109707942 0.240198758942252 0.867141403865717 0.666666666666667 15.3 15 3 bowed ulna 0.0922170109707942 0.240198758942252 0.867141403865717 0.666666666666667 15.3 15 3 abnormal cochlear outer hair cell physiology 0.0922170109707942 0.240198758942252 0.867141403865717 0.666666666666667 15.3 15 3 decreased keratinocyte proliferation 0.0922170109707942 0.240198758942252 0.867141403865717 0.666666666666667 15.3 15 3 hydrometra 0.0922170109707942 0.240198758942252 0.867141403865717 0.666666666666667 15.3 15 3 abnormal behavioral response to addictive substance 0.0922170109707942 0.240198758942252 0.867141403865717 0.666666666666667 15.3 15 3 decreased prostaglandin level 0.0922170109707942 0.240198758942252 0.867141403865717 0.666666666666667 15.3 15 3 embryonic lethality between implantation and placentation, incomplete penetrance 0.0922170109707942 0.240198758942252 0.867141403865717 0.666666666666667 15.3 15 3 hydronephrosis 1.49146473072125e-05 0.000210796506685745 0.867141403865717 0.666666666666667 15.3 15 3 abnormal muscle morphology 0.00204024896097687 0.0136795668205659 0.867141403865717 0.666666666666667 15.3 15 3 abnormal spleen white pulp morphology 0.00204024896097687 0.0136795668205659 0.867141403865717 0.666666666666667 15.3 15 3 left pulmonary isomerism 0.0274341496149365 0.104692600344837 0.867141403865717 0.666666666666667 15.3 15 3 abnormal erythrocyte physiology 0.0274341496149365 0.104692600344837 0.867141403865717 0.666666666666667 15.3 15 3 decreased cochlear outer hair cell number 0.0274341496149365 0.104692600344837 0.867141403865717 0.666666666666667 15.3 15 3 increased keratinocyte proliferation 0.0274341496149365 0.104692600344837 0.867141403865717 0.666666666666667 15.3 15 3 abnormal tumor vascularization 0.0274341496149365 0.104692600344837 0.867141403865717 0.666666666666667 15.3 15 3 vascular ring 0.0274341496149365 0.104692600344837 0.867141403865717 0.666666666666667 15.3 15 3 increased body weight 2.60925618910704e-12 1.26029607192306e-10 0.865205820374946 0.665178571428571 15.3 15 3 abnormal glucose homeostasis 2.97831056010645e-10 1.07370253887895e-08 0.864759147261691 0.664835164835165 15.3 15 3 decreased circulating HDL cholesterol level 1.34708745444466e-07 3.0883687031623e-06 0.863754132756867 0.6640625 15.3 15 3 improved glucose tolerance 8.44646345063405e-11 3.36169245335235e-09 0.862717213029668 0.663265306122449 15.3 15 3 increased circulating creatinine level 1.63719123698512e-05 0.000228152000112073 0.8620998840758 0.662790697674419 15.3 15 3 short tail 2.31329031753552e-05 0.000311886702702959 0.861917660468936 0.662650602409639 15.3 15 3 abnormal lipid level 2.31329031753552e-05 0.000311886702702959 0.861917660468936 0.662650602409639 15.3 15 3 increased blood urea nitrogen level 2.69247778120896e-08 6.76519038460333e-07 0.861161118321816 0.662068965517241 15.3 15 3 cataract 4.1083759228618e-07 8.30860577895832e-06 0.859974945982529 0.661157024793388 15.3 15 3 abnormal spleen morphology 1.38966078680195e-09 4.48932624307773e-08 0.85966604693584 0.660919540229885 15.3 15 3 abnormal seminal vesicle morphology 0.000535387425177106 0.00473941715348061 0.85939906990263 0.660714285714286 15.3 15 3 abnormal mesoderm development 0.000762644106734284 0.00609228947829097 0.858960824583965 0.660377358490566 15.3 15 3 abnormal liver physiology 4.51228066655561e-06 7.31224635704045e-05 0.85846998982706 0.66 15.3 15 3 kidney inflammation 0.00108781765760894 0.00831319945714976 0.85846998982706 0.66 15.3 15 3 decreased oocyte number 0.00108781765760894 0.00831319945714976 0.85846998982706 0.66 15.3 15 3 decreased respiratory quotient 0.00108781765760894 0.00831319945714976 0.85846998982706 0.66 15.3 15 3 osteoporosis 0.00222362454883292 0.0147894814578125 0.857287524276334 0.659090909090909 15.3 15 3 renal interstitial fibrosis 0.00222362454883292 0.0147894814578125 0.857287524276334 0.659090909090909 15.3 15 3 circling 2.52482649511487e-05 0.000338571746986427 0.856939740290826 0.658823529411765 15.3 15 3 no abnormal phenotype detected 5.63485103582498e-83 1.40166919516146e-79 0.85689564088056 0.658789625360231 15.3 15 3 liver fibrosis 0.00318799069004309 0.0194604339668275 0.856566508696623 0.658536585365854 15.3 15 3 abnormal frontal bone morphology 0.0045806830524923 0.0257211040475724 0.855731648551695 0.657894736842105 15.3 15 3 decreased hair follicle number 0.0045806830524923 0.0257211040475724 0.855731648551695 0.657894736842105 15.3 15 3 decreased threshold for auditory brainstem response 0.0045806830524923 0.0257211040475724 0.855731648551695 0.657894736842105 15.3 15 3 decreased bone mineral density 1.53248594546208e-13 8.86525299845794e-12 0.855731648551695 0.657894736842105 15.3 15 3 increased circulating HDL cholesterol level 3.48672346012259e-06 5.84055529094609e-05 0.854753669524778 0.657142857142857 15.3 15 3 decreased triglyceride level 0.00659859477910796 0.03477543329032 0.854753669524778 0.657142857142857 15.3 15 3 decreased glycogen level 0.00659859477910796 0.03477543329032 0.854753669524778 0.657142857142857 15.3 15 3 decreased circulating thyroxine level 0.00659859477910796 0.03477543329032 0.854753669524778 0.657142857142857 15.3 15 3 increased red blood cell distribution width 0.00659859477910796 0.03477543329032 0.854753669524778 0.657142857142857 15.3 15 3 kinked tail 4.91244599476314e-06 7.73399329871729e-05 0.854389324397104 0.656862745098039 15.3 15 3 retinal degeneration 9.76097300642625e-06 0.000141990762301084 0.853592319430315 0.65625 15.3 15 3 decreased caudal vertebrae number 0.000287781930054654 0.00278002932431437 0.853592319430315 0.65625 15.3 15 3 increased sacral vertebrae number 0.000287781930054654 0.00278002932431437 0.853592319430315 0.65625 15.3 15 3 abnormal lymphatic vessel morphology 0.00953386209584865 0.0459602363632239 0.853592319430315 0.65625 15.3 15 3 increased double-negative T cell number 0.000408662879134105 0.0037236223877146 0.85292597101546 0.655737704918033 15.3 15 3 decreased insulin secretion 1.94239333722365e-05 0.000265478210238673 0.852689047134622 0.655555555555556 15.3 15 3 thrombocytopenia 6.87873361933526e-08 1.63740190221019e-06 0.852190690005963 0.655172413793103 15.3 15 3 thrombocytosis 0.000580894661877304 0.00496555144817799 0.852190690005963 0.655172413793103 15.3 15 3 increased double-positive T cell number 0.0138236370370538 0.062806022154651 0.852190690005963 0.655172413793103 15.3 15 3 increased bone mineral density 1.90892818712463e-06 3.33225183541931e-05 0.851793768399067 0.654867256637168 15.3 15 3 abnormal rostral-caudal axis patterning 0.000826618863448153 0.0065588976804698 0.851375196522704 0.654545454545455 15.3 15 3 absent corpus luteum 0.001177717885483 0.00894526180195103 0.85046560763753 0.653846153846154 15.3 15 3 abnormal skin condition 0.001177717885483 0.00894526180195103 0.85046560763753 0.653846153846154 15.3 15 3 decreased kidney weight 0.001177717885483 0.00894526180195103 0.85046560763753 0.653846153846154 15.3 15 3 abnormal stomach morphology 0.020129101801403 0.0809557651269038 0.85046560763753 0.653846153846154 15.3 15 3 increased leukemia incidence 0.020129101801403 0.0809557651269038 0.85046560763753 0.653846153846154 15.3 15 3 pulmonary edema 0.020129101801403 0.0809557651269038 0.85046560763753 0.653846153846154 15.3 15 3 decreased bone resorption 0.020129101801403 0.0809557651269038 0.85046560763753 0.653846153846154 15.3 15 3 abnormal T cell differentiation 7.50215349730271e-06 0.000112758953622601 0.849970286957485 0.653465346534653 15.3 15 3 abnormal eye electrophysiology 1.0443730389056e-06 1.9172530880278e-05 0.849225259157748 0.652892561983471 15.3 15 3 decreased T cell number 2.07877929190082e-08 5.27649335571764e-07 0.84829050378168 0.652173913043478 15.3 15 3 abnormal inner ear morphology 0.00240077725602264 0.0156846591274678 0.84829050378168 0.652173913043478 15.3 15 3 bidirectional circling 0.0294641128657555 0.107887135400572 0.84829050378168 0.652173913043478 15.3 15 3 failure of embryo implantation 0.0294641128657555 0.107887135400572 0.84829050378168 0.652173913043478 15.3 15 3 abnormal ulna morphology 0.0294641128657555 0.107887135400572 0.84829050378168 0.652173913043478 15.3 15 3 abnormal hepatocyte physiology 0.0294641128657555 0.107887135400572 0.84829050378168 0.652173913043478 15.3 15 3 abnormal hematopoietic stem cell physiology 0.0294641128657555 0.107887135400572 0.84829050378168 0.652173913043478 15.3 15 3 abnormal vascular development 0.00031079850609837 0.00295644850447302 0.847433644686951 0.651515151515151 15.3 15 3 abnormal blood circulation 0.00343623785630509 0.0202071907034489 0.846975324706049 0.651162790697674 15.3 15 3 abnormal skin pigmentation 0.00492790407751915 0.0275787872108114 0.845462868769074 0.65 15.3 15 3 abnormal pericardium morphology 0.0434117734078295 0.142275080832643 0.845462868769074 0.65 15.3 15 3 abnormal cell proliferation 0.0434117734078295 0.142275080832643 0.845462868769074 0.65 15.3 15 3 dilated vasculature 0.0434117734078295 0.142275080832643 0.845462868769074 0.65 15.3 15 3 abnormal heart electrocardiography waveform feature 0.0434117734078295 0.142275080832643 0.845462868769074 0.65 15.3 15 3 increased total body fat amount 4.38195274964408e-07 8.79040924575778e-06 0.844492188093105 0.649253731343284 15.3 15 3 abnormal angiogenesis 0.000166613506048577 0.00173410500542191 0.843705149707184 0.648648648648649 15.3 15 3 increased circulating phosphate level 0.0070829252882154 0.0356294775620542 0.843705149707184 0.648648648648649 15.3 15 3 abnormal hair follicle development 0.0070829252882154 0.0356294775620542 0.843705149707184 0.648648648648649 15.3 15 3 increased trabecular bone volume 0.0070829252882154 0.0356294775620542 0.843705149707184 0.648648648648649 15.3 15 3 increased thermal nociceptive threshold 3.18889852024471e-05 0.00041100440772584 0.84331883782545 0.648351648351648 15.3 15 3 polyphagia 0.00126552107342391 0.00935060764688356 0.843054142647225 0.648148148148148 15.3 15 3 abnormal ovary morphology 0.00023572236656994 0.00235013782301694 0.842714885446965 0.647887323943662 15.3 15 3 increased circulating cholesterol level 9.44359458022456e-09 2.52590769014071e-07 0.842506704892259 0.647727272727273 15.3 15 3 increased T cell number 4.49610580671504e-05 0.00054625607479876 0.842506704892259 0.647727272727273 15.3 15 3 decreased litter size 4.35656292956135e-13 2.35585875810519e-11 0.842454104111533 0.647686832740214 15.3 15 3 decreased circulating alanine transaminase level 0.000333712547925233 0.00313249042627931 0.84163724492849 0.647058823529412 15.3 15 3 increased lung adenocarcinoma incidence 0.00180255957299662 0.0122781341689733 0.84163724492849 0.647058823529412 15.3 15 3 increased kidney weight 0.00180255957299662 0.0122781341689733 0.84163724492849 0.647058823529412 15.3 15 3 abnormal bone remodeling 0.0102067292665217 0.0490613314984982 0.84163724492849 0.647058823529412 15.3 15 3 increased width of hypertrophic chondrocyte zone 0.0102067292665217 0.0490613314984982 0.84163724492849 0.647058823529412 15.3 15 3 hydroureter 0.0645059493721663 0.194967860344184 0.84163724492849 0.647058823529412 15.3 15 3 distended urinary bladder 0.0645059493721663 0.194967860344184 0.84163724492849 0.647058823529412 15.3 15 3 abnormal cranial suture morphology 0.0645059493721663 0.194967860344184 0.84163724492849 0.647058823529412 15.3 15 3 abnormal melanosome morphology 0.0645059493721663 0.194967860344184 0.84163724492849 0.647058823529412 15.3 15 3 pancytopenia 0.0645059493721663 0.194967860344184 0.84163724492849 0.647058823529412 15.3 15 3 enhanced behavioral response to cocaine 0.0645059493721663 0.194967860344184 0.84163724492849 0.647058823529412 15.3 15 3 common atrium 0.0645059493721663 0.194967860344184 0.84163724492849 0.647058823529412 15.3 15 3 abnormal survival 0.0645059493721663 0.194967860344184 0.84163724492849 0.647058823529412 15.3 15 3 abnormal cell cytoskeleton morphology 0.0645059493721663 0.194967860344184 0.84163724492849 0.647058823529412 15.3 15 3 abnormal cardiovascular system morphology 0.00257089570550382 0.016653914238127 0.840043234994914 0.645833333333333 15.3 15 3 decreased food intake 0.000126320406843313 0.0013573305054978 0.83970022019908 0.645569620253165 15.3 15 3 decreased circulating glucose level 9.80765634873052e-13 5.03021549844684e-11 0.83916910051521 0.645161290322581 15.3 15 3 abnormal nose morphology 0.0147527864033575 0.0649514268643396 0.83916910051521 0.645161290322581 15.3 15 3 decreased neuronal precursor cell number 0.0147527864033575 0.0649514268643396 0.83916910051521 0.645161290322581 15.3 15 3 decreased double-negative T cell number 0.0147527864033575 0.0649514268643396 0.83916910051521 0.645161290322581 15.3 15 3 thymus hypoplasia 5.0471471540089e-07 1.00038076060535e-05 0.838865053739661 0.644927536231884 15.3 15 3 abnormal axial skeleton morphology 0.000178407058025545 0.00180768862256026 0.838617015580661 0.644736842105263 15.3 15 3 abnormal myocardial trabeculae morphology 0.00367216594867608 0.0214929712878394 0.838236690403527 0.644444444444444 15.3 15 3 cardiomyopathy 0.00367216594867608 0.0214929712878394 0.838236690403527 0.644444444444444 15.3 15 3 abnormal retinal pigmentation 6.78298003617755e-05 0.000792143795304773 0.83723997614621 0.64367816091954 15.3 15 3 cardiac hypertrophy 2.59366539193124e-05 0.000346867885076826 0.83617206801337 0.642857142857143 15.3 15 3 rib bifurcation 0.0214001422217372 0.0850478702987528 0.83617206801337 0.642857142857143 15.3 15 3 abnormal retinal inner nuclear layer morphology 0.0214001422217372 0.0850478702987528 0.83617206801337 0.642857142857143 15.3 15 3 absent atrioventricular cushions 0.0969471500306202 0.251335107557236 0.83617206801337 0.642857142857143 15.3 15 3 decreased coping response 0.0969471500306202 0.251335107557236 0.83617206801337 0.642857142857143 15.3 15 3 abnormal decidualization 0.0969471500306202 0.251335107557236 0.83617206801337 0.642857142857143 15.3 15 3 abnormal pancreas development 0.0969471500306202 0.251335107557236 0.83617206801337 0.642857142857143 15.3 15 3 abnormal maternal decidual layer morphology 0.0969471500306202 0.251335107557236 0.83617206801337 0.642857142857143 15.3 15 3 increased pulmonary respiratory rate 0.0969471500306202 0.251335107557236 0.83617206801337 0.642857142857143 15.3 15 3 decreased tongue size 0.0969471500306202 0.251335107557236 0.83617206801337 0.642857142857143 15.3 15 3 sternebra fusion 0.0969471500306202 0.251335107557236 0.83617206801337 0.642857142857143 15.3 15 3 decreased response to antigen 0.0969471500306202 0.251335107557236 0.83617206801337 0.642857142857143 15.3 15 3 decreased compact bone thickness 0.000504224634771146 0.00451172222659434 0.834785381333414 0.641791044776119 15.3 15 3 increased circulating bilirubin level 0.00192048148955968 0.0129463352446604 0.834419086738709 0.641509433962264 15.3 15 3 increased circulating alanine transaminase level 0.0001901590047716 0.00192284766003803 0.833789811409343 0.641025641025641 15.3 15 3 abnormal response to injury 0.00753122584340265 0.0376016262423853 0.833789811409343 0.641025641025641 15.3 15 3 enlarged liver 2.76207855822082e-05 0.00036449179912861 0.832455747711089 0.64 15.3 15 3 diaphragmatic hernia 0.0311765634461932 0.113379680661412 0.832455747711089 0.64 15.3 15 3 decreased placenta weight 0.0311765634461932 0.113379680661412 0.832455747711089 0.64 15.3 15 3 impaired conditioned place preference behavior 0.0311765634461932 0.113379680661412 0.832455747711089 0.64 15.3 15 3 abnormal reflex 0.0108189107473862 0.0509697736441726 0.831010512037979 0.638888888888889 15.3 15 3 hepatic necrosis 0.00389515114442158 0.0226382908218427 0.830241769658665 0.638297872340426 15.3 15 3 dermatitis 0.00143334251890385 0.0102602575993477 0.829764619216333 0.637931034482759 15.3 15 3 abnormal retinal pigment epithelium morphology 0.000201827457268867 0.0020366969572264 0.829203967446592 0.6375 15.3 15 3 increased spleen weight 1.12571985536616e-05 0.000161396434595004 0.828772315199093 0.63716814159292 15.3 15 3 enlarged pericardium 0.0155804147083093 0.0651913903901083 0.827725885508185 0.636363636363636 15.3 15 3 decreased sensitivity to xenobiotic induced morbidity/mortality 0.0155804147083093 0.0651913903901083 0.827725885508185 0.636363636363636 15.3 15 3 teratozoospermia 0.00010785009937737 0.0011818375427366 0.827725885508185 0.636363636363636 15.3 15 3 increased circulating calcium level 0.00203359994088146 0.0136718374403855 0.827725885508185 0.636363636363636 15.3 15 3 decreased circulating calcium level 0.00203359994088146 0.0136718374403855 0.827725885508185 0.636363636363636 15.3 15 3 abnormal myelopoiesis 0.00555831114438134 0.0304544030212524 0.827725885508185 0.636363636363636 15.3 15 3 abnormal amino acid level 0.00555831114438134 0.0304544030212524 0.827725885508185 0.636363636363636 15.3 15 3 abnormal germ layer development 0.0456590464826726 0.149148887886603 0.827725885508185 0.636363636363636 15.3 15 3 abnormal tracheal cartilage morphology 0.0456590464826726 0.149148887886603 0.827725885508185 0.636363636363636 15.3 15 3 abnormal temporal bone morphology 0.0456590464826726 0.149148887886603 0.827725885508185 0.636363636363636 15.3 15 3 rough coat 0.0456590464826726 0.149148887886603 0.827725885508185 0.636363636363636 15.3 15 3 embryonic lethality before implantation, incomplete penetrance 0.0456590464826726 0.149148887886603 0.827725885508185 0.636363636363636 15.3 15 3 absent semicircular canals 0.148073349965622 0.341206538248713 0.827725885508185 0.636363636363636 15.3 15 3 abnormal sphenoid bone morphology 0.148073349965622 0.341206538248713 0.827725885508185 0.636363636363636 15.3 15 3 decreased atrioventricular cushion size 0.148073349965622 0.341206538248713 0.827725885508185 0.636363636363636 15.3 15 3 abnormal sebaceous gland morphology 0.148073349965622 0.341206538248713 0.827725885508185 0.636363636363636 15.3 15 3 abnormal enteric ganglia morphology 0.148073349965622 0.341206538248713 0.827725885508185 0.636363636363636 15.3 15 3 abnormal glossopharyngeal ganglion morphology 0.148073349965622 0.341206538248713 0.827725885508185 0.636363636363636 15.3 15 3 impaired myelopoiesis 0.148073349965622 0.341206538248713 0.827725885508185 0.636363636363636 15.3 15 3 abnormal bronchiole morphology 0.148073349965622 0.341206538248713 0.827725885508185 0.636363636363636 15.3 15 3 variable body spotting 0.148073349965622 0.341206538248713 0.827725885508185 0.636363636363636 15.3 15 3 abnormal frequency of paradoxical sleep 0.148073349965622 0.341206538248713 0.827725885508185 0.636363636363636 15.3 15 3 loss of cortex neurons 0.148073349965622 0.341206538248713 0.827725885508185 0.636363636363636 15.3 15 3 abnormal lymph circulation 0.148073349965622 0.341206538248713 0.827725885508185 0.636363636363636 15.3 15 3 abnormal ureter development 0.148073349965622 0.341206538248713 0.827725885508185 0.636363636363636 15.3 15 3 increased circulating triiodothyronine level 0.148073349965622 0.341206538248713 0.827725885508185 0.636363636363636 15.3 15 3 abnormal platelet aggregation 0.148073349965622 0.341206538248713 0.827725885508185 0.636363636363636 15.3 15 3 abnormal superovulation 0.148073349965622 0.341206538248713 0.827725885508185 0.636363636363636 15.3 15 3 decreased palatine bone horizontal plate size 0.148073349965622 0.341206538248713 0.827725885508185 0.636363636363636 15.3 15 3 shortened PR interval 0.148073349965622 0.341206538248713 0.827725885508185 0.636363636363636 15.3 15 3 abnormal brain ependyma motile cilium morphology 0.148073349965622 0.341206538248713 0.827725885508185 0.636363636363636 15.3 15 3 decreased B cell number 4.41187297800989e-09 1.2911216509176e-07 0.82715187310492 0.635922330097087 15.3 15 3 abnormal female meiosis 0.00288781092499391 0.0184341609005404 0.82545191329525 0.634615384615385 15.3 15 3 scaly skin 0.00794375394914429 0.0393235581064605 0.824841823189341 0.634146341463415 15.3 15 3 abnormal cholesterol homeostasis 0.00794375394914429 0.0393235581064605 0.824841823189341 0.634146341463415 15.3 15 3 increased bone trabecula number 0.00794375394914429 0.0393235581064605 0.824841823189341 0.634146341463415 15.3 15 3 hunched posture 0.000300225552923815 0.00288344039728954 0.823235509999098 0.632911392405063 15.3 15 3 abnormal respiratory system physiology 0.00410483664962746 0.0238291275751419 0.822899495505222 0.63265306122449 15.3 15 3 abnormal compact bone morphology 0.0113724834065978 0.0528767335960973 0.821502382609627 0.631578947368421 15.3 15 3 small superior vagus ganglion 0.0673110798693958 0.202584768511944 0.821502382609627 0.631578947368421 15.3 15 3 shiny skin 0.0673110798693958 0.202584768511944 0.821502382609627 0.631578947368421 15.3 15 3 short vibrissae 0.0673110798693958 0.202584768511944 0.821502382609627 0.631578947368421 15.3 15 3 unresponsive to tactile stimuli 0.0673110798693958 0.202584768511944 0.821502382609627 0.631578947368421 15.3 15 3 decreased tumor incidence 0.0673110798693958 0.202584768511944 0.821502382609627 0.631578947368421 15.3 15 3 oliguria 0.0673110798693958 0.202584768511944 0.821502382609627 0.631578947368421 15.3 15 3 decreased liver regeneration 0.0673110798693958 0.202584768511944 0.821502382609627 0.631578947368421 15.3 15 3 abnormal cell adhesion 0.00303391419699046 0.0186572597404543 0.818966881428733 0.62962962962963 15.3 15 3 abnormal osteoblast physiology 0.00303391419699046 0.0186572597404543 0.818966881428733 0.62962962962963 15.3 15 3 decreased platelet aggregation 0.00303391419699046 0.0186572597404543 0.818966881428733 0.62962962962963 15.3 15 3 thin epidermis 0.0326096895255135 0.11833202435407 0.818966881428733 0.62962962962963 15.3 15 3 cryptorchism 0.0326096895255135 0.11833202435407 0.818966881428733 0.62962962962963 15.3 15 3 abnormal single cell response 0.0326096895255135 0.11833202435407 0.818966881428733 0.62962962962963 15.3 15 3 weight loss 1.78884464055811e-07 4.02692402116589e-06 0.817590466501962 0.628571428571429 15.3 15 3 impaired fertilization 0.000837511886435307 0.00662419973770374 0.817590466501962 0.628571428571429 15.3 15 3 thick epidermis 0.000837511886435307 0.00662419973770374 0.817590466501962 0.628571428571429 15.3 15 3 abnormal artery morphology 0.0163128030144527 0.0680840562054547 0.817590466501962 0.628571428571429 15.3 15 3 holoprosencephaly 0.0163128030144527 0.0680840562054547 0.817590466501962 0.628571428571429 15.3 15 3 increased urine protein level 0.000443650593554938 0.00403055010001367 0.817114015181157 0.628205128205128 15.3 15 3 decreased oxygen consumption 0.00832127421133375 0.0407155350915293 0.816726205966548 0.627906976744186 15.3 15 3 abnormal gastrulation 0.00430107918464649 0.0245979977461203 0.816133085991263 0.627450980392157 15.3 15 3 abnormal cervical vertebrae morphology 0.00430107918464649 0.0245979977461203 0.816133085991263 0.627450980392157 15.3 15 3 abnormal colon morphology 0.00224436544570874 0.0149075007909225 0.815700812110971 0.627118644067797 15.3 15 3 abnormal pancreatic beta cell morphology 0.0118700954532085 0.0548826439402529 0.81294506612411 0.625 15.3 15 3 abnormal adrenal gland morphology 0.0474480269539947 0.154586728288228 0.81294506612411 0.625 15.3 15 3 hemolytic anemia 0.0474480269539947 0.154586728288228 0.81294506612411 0.625 15.3 15 3 decreased ovulation rate 0.0474480269539947 0.154586728288228 0.81294506612411 0.625 15.3 15 3 abnormal retinal ganglion layer morphology 0.0474480269539947 0.154586728288228 0.81294506612411 0.625 15.3 15 3 increased circulating follicle stimulating hormone level 0.0234509935825391 0.0913615450846766 0.81294506612411 0.625 15.3 15 3 absent mandible 0.100075115896592 0.257565287938719 0.81294506612411 0.625 15.3 15 3 vasculature congestion 0.100075115896592 0.257565287938719 0.81294506612411 0.625 15.3 15 3 delayed hair appearance 0.100075115896592 0.257565287938719 0.81294506612411 0.625 15.3 15 3 abnormal meiosis 0.100075115896592 0.257565287938719 0.81294506612411 0.625 15.3 15 3 increased intestinal adenocarcinoma incidence 0.100075115896592 0.257565287938719 0.81294506612411 0.625 15.3 15 3 abnormal pulmonary elastic fiber morphology 0.100075115896592 0.257565287938719 0.81294506612411 0.625 15.3 15 3 increased pancreatic beta cell number 0.100075115896592 0.257565287938719 0.81294506612411 0.625 15.3 15 3 small epididymis 0.100075115896592 0.257565287938719 0.81294506612411 0.625 15.3 15 3 increased thymus weight 0.100075115896592 0.257565287938719 0.81294506612411 0.625 15.3 15 3 impaired behavioral response to addictive substance 0.100075115896592 0.257565287938719 0.81294506612411 0.625 15.3 15 3 abnormal bone marrow development 0.23182148554565 0.423078463165666 0.81294506612411 0.625 15.3 15 3 absent pre-B cells 0.23182148554565 0.423078463165666 0.81294506612411 0.625 15.3 15 3 failure of vascular branching 0.23182148554565 0.423078463165666 0.81294506612411 0.625 15.3 15 3 pointed snout 0.23182148554565 0.423078463165666 0.81294506612411 0.625 15.3 15 3 abnormal pupil morphology 0.23182148554565 0.423078463165666 0.81294506612411 0.625 15.3 15 3 dry eyes 0.23182148554565 0.423078463165666 0.81294506612411 0.625 15.3 15 3 unidirectional circling 0.23182148554565 0.423078463165666 0.81294506612411 0.625 15.3 15 3 spinning 0.23182148554565 0.423078463165666 0.81294506612411 0.625 15.3 15 3 preneoplasia 0.23182148554565 0.423078463165666 0.81294506612411 0.625 15.3 15 3 abnormal hepatobiliary system morphology 0.23182148554565 0.423078463165666 0.81294506612411 0.625 15.3 15 3 abnormal secondary sex determination 0.23182148554565 0.423078463165666 0.81294506612411 0.625 15.3 15 3 vascular smooth muscle hypertrophy 0.23182148554565 0.423078463165666 0.81294506612411 0.625 15.3 15 3 early eyelid opening 0.23182148554565 0.423078463165666 0.81294506612411 0.625 15.3 15 3 abnormal soft palate morphology 0.23182148554565 0.423078463165666 0.81294506612411 0.625 15.3 15 3 loss of GABAergic neurons 0.23182148554565 0.423078463165666 0.81294506612411 0.625 15.3 15 3 urinary incontinence 0.23182148554565 0.423078463165666 0.81294506612411 0.625 15.3 15 3 hair follicle degeneration 0.23182148554565 0.423078463165666 0.81294506612411 0.625 15.3 15 3 abnormal ovary development 0.23182148554565 0.423078463165666 0.81294506612411 0.625 15.3 15 3 abnormal eyelid aperture 0.23182148554565 0.423078463165666 0.81294506612411 0.625 15.3 15 3 long femur 0.23182148554565 0.423078463165666 0.81294506612411 0.625 15.3 15 3 bowed fibula 0.23182148554565 0.423078463165666 0.81294506612411 0.625 15.3 15 3 small frontal bone 0.23182148554565 0.423078463165666 0.81294506612411 0.625 15.3 15 3 absent cochlear microphonics 0.23182148554565 0.423078463165666 0.81294506612411 0.625 15.3 15 3 abnormal vestibular labyrinth morphology 0.23182148554565 0.423078463165666 0.81294506612411 0.625 15.3 15 3 abnormal olfactory tract morphology 0.23182148554565 0.423078463165666 0.81294506612411 0.625 15.3 15 3 Sertoli cell hypoplasia 0.23182148554565 0.423078463165666 0.81294506612411 0.625 15.3 15 3 abnormal mast cell differentiation 0.23182148554565 0.423078463165666 0.81294506612411 0.625 15.3 15 3 stomach epithelial hyperplasia 0.23182148554565 0.423078463165666 0.81294506612411 0.625 15.3 15 3 hypergranulosis 0.23182148554565 0.423078463165666 0.81294506612411 0.625 15.3 15 3 abnormal epidermal lamellar body morphology 0.23182148554565 0.423078463165666 0.81294506612411 0.625 15.3 15 3 abnormal mitotic spindle assembly checkpoint 0.23182148554565 0.423078463165666 0.81294506612411 0.625 15.3 15 3 abnormal base-excision repair 0.23182148554565 0.423078463165666 0.81294506612411 0.625 15.3 15 3 abnormal sphingomyelin level 0.23182148554565 0.423078463165666 0.81294506612411 0.625 15.3 15 3 abnormal frontonasal prominence morphology 0.23182148554565 0.423078463165666 0.81294506612411 0.625 15.3 15 3 skin fibrosis 0.23182148554565 0.423078463165666 0.81294506612411 0.625 15.3 15 3 abnormal brain ependyma morphology 0.23182148554565 0.423078463165666 0.81294506612411 0.625 15.3 15 3 abnormal circulating serum amyloid protein level 0.23182148554565 0.423078463165666 0.81294506612411 0.625 15.3 15 3 ostium secundum atrial septal defect 0.23182148554565 0.423078463165666 0.81294506612411 0.625 15.3 15 3 anomalous pulmonary venous connection 0.23182148554565 0.423078463165666 0.81294506612411 0.625 15.3 15 3 myocardial trabeculae hypoplasia 0.23182148554565 0.423078463165666 0.81294506612411 0.625 15.3 15 3 lung situs inversus 0.23182148554565 0.423078463165666 0.81294506612411 0.625 15.3 15 3 decreased lung compliance 0.23182148554565 0.423078463165666 0.81294506612411 0.625 15.3 15 3 abnormal pulmonary acinus morphology 0.23182148554565 0.423078463165666 0.81294506612411 0.625 15.3 15 3 abnormal maxillary prominence morphology 0.23182148554565 0.423078463165666 0.81294506612411 0.625 15.3 15 3 abnormal kidney mesenchyme morphology 0.23182148554565 0.423078463165666 0.81294506612411 0.625 15.3 15 3 increased circulating lactate level 0.23182148554565 0.423078463165666 0.81294506612411 0.625 15.3 15 3 embryo cyst 0.23182148554565 0.423078463165666 0.81294506612411 0.625 15.3 15 3 increased mammary gland apoptosis 0.23182148554565 0.423078463165666 0.81294506612411 0.625 15.3 15 3 decreased white adipose tissue mass 0.23182148554565 0.423078463165666 0.81294506612411 0.625 15.3 15 3 increased brain apoptosis 0.23182148554565 0.423078463165666 0.81294506612411 0.625 15.3 15 3 decreased basal metabolism 0.23182148554565 0.423078463165666 0.81294506612411 0.625 15.3 15 3 obese 0.000651144389022397 0.00546280495006143 0.810833520497813 0.623376623376623 15.3 15 3 abnormal ectoderm development 0.00866490323142532 0.0421799350062045 0.809331976941336 0.622222222222222 15.3 15 3 sparse hair 0.000484198312973548 0.00436392501275979 0.808979480435699 0.621951219512195 15.3 15 3 abnormal response/metabolism to endogenous compounds 0.000484198312973548 0.00436392501275979 0.808979480435699 0.621951219512195 15.3 15 3 abnormal vocalization 0.0169566011445953 0.0703857989160688 0.808550768469385 0.621621621621622 15.3 15 3 increased circulating triglyceride level 4.82727127142776e-06 7.72208185702672e-05 0.807338548426702 0.620689655172414 15.3 15 3 abnormal enzyme/coenzyme level 0.00330064161735884 0.0199881156502155 0.807338548426702 0.620689655172414 15.3 15 3 decreased bone strength 0.0337980597966737 0.121492303098592 0.807338548426702 0.620689655172414 15.3 15 3 decreased B cell proliferation 0.000677911493252439 0.00567779407227422 0.806770799799116 0.620253164556962 15.3 15 3 increased body length 0.00634247545962905 0.0335678887358027 0.806441505595117 0.62 15.3 15 3 testicular atrophy 0.00634247545962905 0.0335678887358027 0.806441505595117 0.62 15.3 15 3 corneal opacity 0.00128105756104392 0.00940009051060991 0.806075107818836 0.619718309859155 15.3 15 3 complete atrioventricular septal defect 0.0693754120712804 0.208545422993728 0.805202732161023 0.619047619047619 15.3 15 3 abnormal tibia morphology 0.0089759930290162 0.0435157913752043 0.802567044003377 0.617021276595745 15.3 15 3 abnormal incisor morphology 0.00342124962948096 0.0201624676053184 0.802105798575788 0.616666666666667 15.3 15 3 female infertility 1.62995309328855e-09 5.23162363813582e-08 0.801942802071302 0.616541353383459 15.3 15 3 impaired macrophage chemotaxis 0.01751849550771 0.0723273984654418 0.80043821895297 0.615384615384615 15.3 15 3 abnormal xiphoid process morphology 0.0488525020778574 0.157783540302756 0.80043821895297 0.615384615384615 15.3 15 3 abnormal kidney cortex morphology 0.0488525020778574 0.157783540302756 0.80043821895297 0.615384615384615 15.3 15 3 abnormal erythrocyte osmotic lysis 0.0488525020778574 0.157783540302756 0.80043821895297 0.615384615384615 15.3 15 3 abnormal sympathetic ganglion morphology 0.150476793285428 0.342762140950889 0.80043821895297 0.615384615384615 15.3 15 3 pup cannibalization 0.150476793285428 0.342762140950889 0.80043821895297 0.615384615384615 15.3 15 3 increased pituitary adenoma incidence 0.150476793285428 0.342762140950889 0.80043821895297 0.615384615384615 15.3 15 3 dystrophic cardiac calcinosis 0.150476793285428 0.342762140950889 0.80043821895297 0.615384615384615 15.3 15 3 abnormal tail bud morphology 0.150476793285428 0.342762140950889 0.80043821895297 0.615384615384615 15.3 15 3 abnormal otolith morphology 0.150476793285428 0.342762140950889 0.80043821895297 0.615384615384615 15.3 15 3 absent lateral semicircular canal 0.150476793285428 0.342762140950889 0.80043821895297 0.615384615384615 15.3 15 3 abnormal dopaminergic neuron morphology 0.150476793285428 0.342762140950889 0.80043821895297 0.615384615384615 15.3 15 3 decreased alcohol consumption 0.150476793285428 0.342762140950889 0.80043821895297 0.615384615384615 15.3 15 3 abnormal exocrine pancreas morphology 0.150476793285428 0.342762140950889 0.80043821895297 0.615384615384615 15.3 15 3 increased circulating thyroxine level 0.150476793285428 0.342762140950889 0.80043821895297 0.615384615384615 15.3 15 3 empty decidua capsularis 0.150476793285428 0.342762140950889 0.80043821895297 0.615384615384615 15.3 15 3 increased prostaglandin level 0.150476793285428 0.342762140950889 0.80043821895297 0.615384615384615 15.3 15 3 abnormal aorta tunica media morphology 0.150476793285428 0.342762140950889 0.80043821895297 0.615384615384615 15.3 15 3 increased liver weight 0.000540200683142428 0.00475663433386474 0.798164246740035 0.613636363636364 15.3 15 3 abnormal cranial ganglia morphology 0.0347723664606711 0.122173900324696 0.79721064548945 0.612903225806452 15.3 15 3 abnormal heart left ventricle morphology 0.0019173483518658 0.0129427517646301 0.794879620210241 0.611111111111111 15.3 15 3 abnormal uterus morphology 0.0249460622912715 0.0965921570637301 0.794879620210241 0.611111111111111 15.3 15 3 abnormal limb bone morphology 0.0249460622912715 0.0965921570637301 0.794879620210241 0.611111111111111 15.3 15 3 short radius 0.0249460622912715 0.0965921570637301 0.794879620210241 0.611111111111111 15.3 15 3 abnormal retinal rod cell morphology 0.10204517797029 0.260881171840797 0.794879620210241 0.611111111111111 15.3 15 3 abnormal Peyer's patch follicle morphology 0.10204517797029 0.260881171840797 0.794879620210241 0.611111111111111 15.3 15 3 abnormal white adipose tissue morphology 0.10204517797029 0.260881171840797 0.794879620210241 0.611111111111111 15.3 15 3 decreased cellular sensitivity to gamma-irradiation 0.10204517797029 0.260881171840797 0.794879620210241 0.611111111111111 15.3 15 3 decreased activity of thyroid 0.10204517797029 0.260881171840797 0.794879620210241 0.611111111111111 15.3 15 3 long tibia 0.10204517797029 0.260881171840797 0.794879620210241 0.611111111111111 15.3 15 3 abnormal anterior eye segment morphology 0.10204517797029 0.260881171840797 0.794879620210241 0.611111111111111 15.3 15 3 decreased fluid intake 0.10204517797029 0.260881171840797 0.794879620210241 0.611111111111111 15.3 15 3 abnormal small intestine morphology 0.00676246067362759 0.0348634630583391 0.794879620210241 0.611111111111111 15.3 15 3 abnormal thoracic vertebrae morphology 0.00495394345124594 0.0276298976120499 0.79365484421608 0.610169491525424 15.3 15 3 increased monocyte cell number 0.000307103238775559 0.00293251173302957 0.793434384537131 0.61 15.3 15 3 abnormal tooth morphology 0.00363743426767455 0.0213399003321709 0.792621439471007 0.609375 15.3 15 3 abnormal food intake 0.0026760972857657 0.0172010129156128 0.791737803529568 0.608695652173913 15.3 15 3 abnormal carpal bone morphology 0.0708511654423214 0.211957034320835 0.791737803529568 0.608695652173913 15.3 15 3 abnormal cranial nerve morphology 0.0708511654423214 0.211957034320835 0.791737803529568 0.608695652173913 15.3 15 3 conjunctivitis 0.0708511654423214 0.211957034320835 0.791737803529568 0.608695652173913 15.3 15 3 abnormal cardiovascular development 0.0708511654423214 0.211957034320835 0.791737803529568 0.608695652173913 15.3 15 3 abnormal crista ampullaris morphology 0.0708511654423214 0.211957034320835 0.791737803529568 0.608695652173913 15.3 15 3 abnormal corneal stroma morphology 0.0708511654423214 0.211957034320835 0.791737803529568 0.608695652173913 15.3 15 3 abnormal lens development 0.0708511654423214 0.211957034320835 0.791737803529568 0.608695652173913 15.3 15 3 microphthalmia 1.17406627524592e-05 0.000167844244808863 0.790628927054036 0.607843137254902 15.3 15 3 abnormal eye development 0.00694372584444565 0.0354646781335377 0.78971806423485 0.607142857142857 15.3 15 3 abnormal stria vascularis morphology 0.0499335353586224 0.15975520154929 0.78971806423485 0.607142857142857 15.3 15 3 dextrocardia 0.0355595764659695 0.122173900324696 0.788310367150652 0.606060606060606 15.3 15 3 abnormal epidermis stratum basale morphology 0.0355595764659695 0.122173900324696 0.788310367150652 0.606060606060606 15.3 15 3 cardiovascular system phenotype 0.0355595764659695 0.122173900324696 0.788310367150652 0.606060606060606 15.3 15 3 decreased liver weight 0.00274618830119446 0.0176287571592806 0.787755219004771 0.605633802816901 15.3 15 3 abnormal renal glomerulus morphology 0.000241099569117005 0.00238463291522287 0.78758714663033 0.605504587155963 15.3 15 3 increased bone marrow cell number 0.0255189150095248 0.0983397383209806 0.787273116667559 0.605263157894737 15.3 15 3 abnormal enzyme/coenzyme activity 1.23971813600715e-05 0.000176721997897867 0.78705509586538 0.605095541401274 15.3 15 3 abnormal male reproductive system morphology 0.0184223548279366 0.0759960325613469 0.786477087227046 0.604651162790698 15.3 15 3 abnormal pancreatic islet morphology 0.0097294000673367 0.0468574688625364 0.785335611048197 0.60377358490566 15.3 15 3 abnormal lens morphology 0.000104089036731739 0.00114567026048761 0.782459626144456 0.6015625 15.3 15 3 ruffled hair 0.0718552222156966 0.214419116222403 0.780427263479146 0.6 15.3 15 3 increased pre-B cell number 0.0718552222156966 0.214419116222403 0.780427263479146 0.6 15.3 15 3 spleen hypoplasia 0.000469191930019011 0.00424405427608106 0.780427263479145 0.6 15.3 15 3 alopecia 0.000854169376834244 0.00674522642817518 0.780427263479145 0.6 15.3 15 3 abnormal eye physiology 0.00725298418389337 0.0363745930593442 0.780427263479145 0.6 15.3 15 3 impaired ovarian folliculogenesis 0.0259910955894626 0.100081811577071 0.780427263479145 0.6 15.3 15 3 ovary cysts 0.036183254225544 0.123804463392078 0.780427263479145 0.6 15.3 15 3 abnormal spleen marginal zone morphology 0.0507416975953042 0.162236468853881 0.780427263479145 0.6 15.3 15 3 abnormal basioccipital bone morphology 0.103160039561745 0.262651584861659 0.780427263479145 0.6 15.3 15 3 increased urine glucose level 0.103160039561745 0.262651584861659 0.780427263479145 0.6 15.3 15 3 brain inflammation 0.103160039561745 0.262651584861659 0.780427263479145 0.6 15.3 15 3 abnormal hair texture 0.103160039561745 0.262651584861659 0.780427263479145 0.6 15.3 15 3 abnormal lens epithelium morphology 0.103160039561745 0.262651584861659 0.780427263479145 0.6 15.3 15 3 absent placental labyrinth 0.103160039561745 0.262651584861659 0.780427263479145 0.6 15.3 15 3 decreased salivation 0.151228723494915 0.342762140950889 0.780427263479145 0.6 15.3 15 3 abnormal epidermis stratum spinosum morphology 0.151228723494915 0.342762140950889 0.780427263479145 0.6 15.3 15 3 placental labyrinth hypoplasia 0.151228723494915 0.342762140950889 0.780427263479145 0.6 15.3 15 3 increased airway responsiveness 0.151228723494915 0.342762140950889 0.780427263479145 0.6 15.3 15 3 arthritis 0.151228723494915 0.342762140950889 0.780427263479145 0.6 15.3 15 3 abnormal aorta wall morphology 0.151228723494915 0.342762140950889 0.780427263479145 0.6 15.3 15 3 liver vascular congestion 0.151228723494915 0.342762140950889 0.780427263479145 0.6 15.3 15 3 herniated liver 0.151228723494915 0.342762140950889 0.780427263479145 0.6 15.3 15 3 small petrosal ganglion 0.229858793472467 0.423078463165666 0.780427263479145 0.6 15.3 15 3 enlarged testis 0.229858793472467 0.423078463165666 0.780427263479145 0.6 15.3 15 3 absent trophoblast giant cells 0.229858793472467 0.423078463165666 0.780427263479145 0.6 15.3 15 3 abnormal gland morphology 0.229858793472467 0.423078463165666 0.780427263479145 0.6 15.3 15 3 abnormal respiratory mechanics 0.229858793472467 0.423078463165666 0.780427263479145 0.6 15.3 15 3 abnormal tibialis anterior morphology 0.229858793472467 0.423078463165666 0.780427263479145 0.6 15.3 15 3 abnormal hypaxial muscle morphology 0.229858793472467 0.423078463165666 0.780427263479145 0.6 15.3 15 3 abnormal reproductive system development 0.229858793472467 0.423078463165666 0.780427263479145 0.6 15.3 15 3 abnormal embryonic erythrocyte morphology 0.229858793472467 0.423078463165666 0.780427263479145 0.6 15.3 15 3 abnormal placental transport 0.229858793472467 0.423078463165666 0.780427263479145 0.6 15.3 15 3 decreased cochlear inner hair cell number 0.229858793472467 0.423078463165666 0.780427263479145 0.6 15.3 15 3 abnormal cochlear inner hair cell physiology 0.229858793472467 0.423078463165666 0.780427263479145 0.6 15.3 15 3 decreased prolactin level 0.229858793472467 0.423078463165666 0.780427263479145 0.6 15.3 15 3 absent coat pigmentation 0.229858793472467 0.423078463165666 0.780427263479145 0.6 15.3 15 3 increased platelet aggregation 0.229858793472467 0.423078463165666 0.780427263479145 0.6 15.3 15 3 absent inguinal lymph nodes 0.229858793472467 0.423078463165666 0.780427263479145 0.6 15.3 15 3 crystalluria 0.229858793472467 0.423078463165666 0.780427263479145 0.6 15.3 15 3 abnormal sperm principal piece morphology 0.229858793472467 0.423078463165666 0.780427263479145 0.6 15.3 15 3 acanthocytosis 0.229858793472467 0.423078463165666 0.780427263479145 0.6 15.3 15 3 common ventricle 0.229858793472467 0.423078463165666 0.780427263479145 0.6 15.3 15 3 aorta stenosis 0.229858793472467 0.423078463165666 0.780427263479145 0.6 15.3 15 3 abnormal left subclavian artery morphology 0.229858793472467 0.423078463165666 0.780427263479145 0.6 15.3 15 3 abnormal pulmonary interalveolar septum morphology 0.229858793472467 0.423078463165666 0.780427263479145 0.6 15.3 15 3 increased compact bone area 0.229858793472467 0.423078463165666 0.780427263479145 0.6 15.3 15 3 abnormal circadian temperature homeostasis 0.229858793472467 0.423078463165666 0.780427263479145 0.6 15.3 15 3 increased fatty acid oxidation 0.229858793472467 0.423078463165666 0.780427263479145 0.6 15.3 15 3 decreased osteoclast cell number 0.0187764193293898 0.0771368176413827 0.780427263479145 0.6 15.3 15 3 increased B cell number 0.000263978809950017 0.00259032461440105 0.778203823982054 0.598290598290598 15.3 15 3 polyuria 0.00292567705498786 0.0184341609005404 0.777048790477071 0.597402597402597 15.3 15 3 maternal effect 0.00541139727042578 0.0298466756323373 0.776544540775269 0.597014925373134 15.3 15 3 increased systemic arterial blood pressure 0.0190726815316458 0.0773183479865512 0.774892318348088 0.595744680851064 15.3 15 3 increased brown adipose tissue amount 0.0366639386397298 0.125105003245991 0.773396387231586 0.594594594594595 15.3 15 3 increased white adipose tissue amount 0.0366639386397298 0.125105003245991 0.773396387231586 0.594594594594595 15.3 15 3 abnormal branching of the mammary ductal tree 0.0366639386397298 0.125105003245991 0.773396387231586 0.594594594594595 15.3 15 3 increased lymphocyte cell number 0.00549856572545549 0.0302938698606213 0.772886903445531 0.594202898550725 15.3 15 3 liver inflammation 0.000380418554208858 0.00350478205035012 0.769587995930824 0.591666666666667 15.3 15 3 abnormal skin morphology 0.0075967557964833 0.0377184232410224 0.768602607971886 0.590909090909091 15.3 15 3 abnormal tail morphology 0.0075967557964833 0.0377184232410224 0.768602607971886 0.590909090909091 15.3 15 3 abnormal circadian rhythm 0.0266742422774067 0.102632912088243 0.768602607971886 0.590909090909091 15.3 15 3 intestinal inflammation 0.103632384588158 0.262778345222267 0.768602607971886 0.590909090909091 15.3 15 3 abnormal basement membrane morphology 0.103632384588158 0.262778345222267 0.768602607971886 0.590909090909091 15.3 15 3 impaired humoral immune response 0.103632384588158 0.262778345222267 0.768602607971886 0.590909090909091 15.3 15 3 increased inflammatory response 0.00169324869093011 0.0118147436709359 0.766735557102318 0.589473684210526 15.3 15 3 increased circulating glucose level 0.000163426877130902 0.00172621807585188 0.765667409796325 0.588652482269504 15.3 15 3 abnormal thrombosis 0.0195117635242437 0.0789837457551767 0.765124768116809 0.588235294117647 15.3 15 3 increased incidence of corneal inflammation 0.150888210931486 0.342762140950889 0.765124768116809 0.588235294117647 15.3 15 3 abnormal duodenum morphology 0.150888210931486 0.342762140950889 0.765124768116809 0.588235294117647 15.3 15 3 delayed heart development 0.150888210931486 0.342762140950889 0.765124768116809 0.588235294117647 15.3 15 3 skin lesions 0.010481223882958 0.0499943325193825 0.763910284357894 0.587301587301587 15.3 15 3 increased circulating aspartate transaminase level 0.010481223882958 0.0499943325193825 0.763910284357894 0.587301587301587 15.3 15 3 increased leukocyte cell number 0.000167312019058549 0.00173411936420059 0.762486406847441 0.586206896551724 15.3 15 3 glomerulosclerosis 0.0143350225368402 0.0642075284003576 0.762486406847441 0.586206896551724 15.3 15 3 abnormal embryonic erythropoiesis 0.0727921257380498 0.216364526981939 0.762486406847441 0.586206896551724 15.3 15 3 increased retinal apoptosis 0.0727921257380498 0.216364526981939 0.762486406847441 0.586206896551724 15.3 15 3 short humerus 0.0372655777581503 0.125522172882057 0.761392452174776 0.585365853658537 15.3 15 3 short ulna 0.0372655777581503 0.125522172882057 0.761392452174776 0.585365853658537 15.3 15 3 head tilt 0.0519153229335261 0.165430932357048 0.758748728382503 0.583333333333333 15.3 15 3 narrow eye opening 0.0519153229335261 0.165430932357048 0.758748728382503 0.583333333333333 15.3 15 3 abnormal cardiac muscle contractility 0.103615559325979 0.262778345222267 0.758748728382503 0.583333333333333 15.3 15 3 prolonged QT interval 0.103615559325979 0.262778345222267 0.758748728382503 0.583333333333333 15.3 15 3 decreased fatty acid level 0.103615559325979 0.262778345222267 0.758748728382503 0.583333333333333 15.3 15 3 increased circulating total protein level 0.103615559325979 0.262778345222267 0.758748728382503 0.583333333333333 15.3 15 3 abnormal rectum morphology 0.226272224558382 0.423078463165666 0.758748728382503 0.583333333333333 15.3 15 3 decreased circulating ketone body level 0.226272224558382 0.423078463165666 0.758748728382503 0.583333333333333 15.3 15 3 abnormal nucleotide metabolism 0.226272224558382 0.423078463165666 0.758748728382503 0.583333333333333 15.3 15 3 absent cochlear hair cells 0.226272224558382 0.423078463165666 0.758748728382503 0.583333333333333 15.3 15 3 abnormal patella morphology 0.226272224558382 0.423078463165666 0.758748728382503 0.583333333333333 15.3 15 3 decreased renal glomerular filtration rate 0.226272224558382 0.423078463165666 0.758748728382503 0.583333333333333 15.3 15 3 impaired behavioral response to cocaine 0.226272224558382 0.423078463165666 0.758748728382503 0.583333333333333 15.3 15 3 persistent right dorsal aorta 0.226272224558382 0.423078463165666 0.758748728382503 0.583333333333333 15.3 15 3 increased type II pneumocyte number 0.226272224558382 0.423078463165666 0.758748728382503 0.583333333333333 15.3 15 3 abnormal respiratory motile cilium morphology 0.226272224558382 0.423078463165666 0.758748728382503 0.583333333333333 15.3 15 3 increased food intake 0.00427654745102495 0.0245979977461203 0.758748728382502 0.583333333333333 15.3 15 3 abnormal femur morphology 0.0106406480292063 0.0507061532043114 0.757130927255887 0.582089552238806 15.3 15 3 abnormal T-helper 2 physiology 0.0197757343769091 0.0799872183131081 0.756777952464626 0.581818181818182 15.3 15 3 abnormal body temperature homeostasis 0.0728530791663351 0.216364526981939 0.755252190463689 0.580645161290323 15.3 15 3 abnormal mitochondrial ATP synthesis coupled electron transport 0.0728530791663351 0.216364526981939 0.755252190463689 0.580645161290323 15.3 15 3 abnormal circulating protein level 0.027173618667741 0.104473533904182 0.754413021363174 0.58 15.3 15 3 thin dermal layer 0.149804562859019 0.342762140950889 0.753043850725491 0.578947368421053 15.3 15 3 increased susceptibility to ischemic brain injury 0.149804562859019 0.342762140950889 0.753043850725491 0.578947368421053 15.3 15 3 abnormal optic vesicle formation 0.149804562859019 0.342762140950889 0.753043850725491 0.578947368421053 15.3 15 3 osteoarthritis 0.149804562859019 0.342762140950889 0.753043850725491 0.578947368421053 15.3 15 3 increased left ventricle weight 0.149804562859019 0.342762140950889 0.753043850725491 0.578947368421053 15.3 15 3 increased circulating VLDL cholesterol level 0.149804562859019 0.342762140950889 0.753043850725491 0.578947368421053 15.3 15 3 eyelids fail to open 0.149804562859019 0.342762140950889 0.753043850725491 0.578947368421053 15.3 15 3 Leydig cell hypoplasia 0.149804562859019 0.342762140950889 0.753043850725491 0.578947368421053 15.3 15 3 thin interventricular septum 0.149804562859019 0.342762140950889 0.753043850725491 0.578947368421053 15.3 15 3 right-sided stomach 0.149804562859019 0.342762140950889 0.753043850725491 0.578947368421053 15.3 15 3 abnormal circulating amino acid level 0.019851783641659 0.0801644672217968 0.753043850725491 0.578947368421053 15.3 15 3 increased macrophage cell number 0.019851783641659 0.0801644672217968 0.753043850725491 0.578947368421053 15.3 15 3 decreased eosinophil cell number 0.0145706832127076 0.0643204516266373 0.751974186164802 0.578125 15.3 15 3 abnormal autopod morphology 0.0374817894694295 0.125994528790819 0.751522550016955 0.577777777777778 15.3 15 3 decreased body temperature 0.0272282135727901 0.104602596544117 0.750410830268409 0.576923076923077 15.3 15 3 abnormal Schwann cell morphology 0.103222567858205 0.262676355547094 0.750410830268409 0.576923076923077 15.3 15 3 increased osteoblast cell number 0.0727067616435287 0.216364526981939 0.74889484879312 0.575757575757576 15.3 15 3 abnormal female reproductive system morphology 0.0519403248928059 0.165430932357048 0.747909460834181 0.575 15.3 15 3 abnormal T-helper 1 physiology 0.0374742016019365 0.125994528790819 0.747217592692799 0.574468085106383 15.3 15 3 decreased neutrophil cell number 0.00181680432375591 0.0122952456486375 0.74485223152568 0.572649572649573 15.3 15 3 abnormal trabecular bone morphology 0.0018189549341502 0.0122952456486375 0.743264060456329 0.571428571428571 15.3 15 3 small ovary 0.00590697223913144 0.0318387723615156 0.743264060456329 0.571428571428571 15.3 15 3 decreased urine osmolality 0.0374020521158543 0.12589662332637 0.743264060456329 0.571428571428571 15.3 15 3 abnormal circulating cholesterol level 0.102538245759945 0.261872573231891 0.743264060456329 0.571428571428571 15.3 15 3 corneal vascularization 0.102538245759945 0.261872573231891 0.743264060456329 0.571428571428571 15.3 15 3 irregularly shaped pupil 0.221849650958506 0.423078463165666 0.743264060456329 0.571428571428571 15.3 15 3 abnormal pinna reflex 0.221849650958506 0.423078463165666 0.743264060456329 0.571428571428571 15.3 15 3 extended life span 0.221849650958506 0.423078463165666 0.743264060456329 0.571428571428571 15.3 15 3 abnormal fluid regulation 0.221849650958506 0.423078463165666 0.743264060456329 0.571428571428571 15.3 15 3 absent otoliths 0.221849650958506 0.423078463165666 0.743264060456329 0.571428571428571 15.3 15 3 vascular smooth muscle hypoplasia 0.221849650958506 0.423078463165666 0.743264060456329 0.571428571428571 15.3 15 3 abnormal iris pigmentation 0.221849650958506 0.423078463165666 0.743264060456329 0.571428571428571 15.3 15 3 decreased cornea thickness 0.221849650958506 0.423078463165666 0.743264060456329 0.571428571428571 15.3 15 3 abnormal renal reabsorbtion 0.221849650958506 0.423078463165666 0.743264060456329 0.571428571428571 15.3 15 3 increased lung compliance 0.221849650958506 0.423078463165666 0.743264060456329 0.571428571428571 15.3 15 3 abnormal hair follicle morphology 0.0198954044774682 0.0802754560222256 0.743264060456329 0.571428571428571 15.3 15 3 impaired adaptive thermogenesis 0.0723899826768038 0.21565279270485 0.743264060456329 0.571428571428571 15.3 15 3 abnormal blood homeostasis 0.00243680095976476 0.0158058471640543 0.741634095411469 0.570175438596491 15.3 15 3 abnormal lipid homeostasis 0.00136087630243377 0.00979791549147326 0.740405352531497 0.569230769230769 15.3 15 3 decreased macrophage cell number 0.051549221819916 0.164501204973754 0.739040969203736 0.568181818181818 15.3 15 3 decreased sensitivity to induced morbidity/mortality 0.051549221819916 0.164501204973754 0.739040969203736 0.568181818181818 15.3 15 3 decreased T cell proliferation 0.000762913838185984 0.00609228947829097 0.738242005993786 0.567567567567568 15.3 15 3 increased granulocyte number 0.0145601417658075 0.0643204516266373 0.738242005993786 0.567567567567568 15.3 15 3 abnormal long bone metaphysis morphology 0.0719327648191338 0.214419116222403 0.738242005993786 0.567567567567568 15.3 15 3 decreased circulating chloride level 0.0719327648191338 0.214419116222403 0.738242005993786 0.567567567567568 15.3 15 3 skin inflammation 0.0719327648191338 0.214419116222403 0.738242005993786 0.567567567567568 15.3 15 3 abnormal hair cycle 0.10162730100164 0.260881171840797 0.73707019328586 0.566666666666667 15.3 15 3 increased metastatic potential 0.10162730100164 0.260881171840797 0.73707019328586 0.566666666666667 15.3 15 3 abnormal pain threshold 0.10162730100164 0.260881171840797 0.73707019328586 0.566666666666667 15.3 15 3 lung inflammation 0.00135632086232023 0.00977926998556978 0.736432589312429 0.566176470588235 15.3 15 3 abnormal blood vessel physiology 0.146247969477746 0.339992358949433 0.735185103277456 0.565217391304348 15.3 15 3 pancreas inflammation 0.146247969477746 0.339992358949433 0.735185103277456 0.565217391304348 15.3 15 3 abnormal nasal cavity morphology 0.146247969477746 0.339992358949433 0.735185103277456 0.565217391304348 15.3 15 3 abnormal sacral vertebrae morphology 0.146247969477746 0.339992358949433 0.735185103277456 0.565217391304348 15.3 15 3 increased autoantibody level 0.0713597707155747 0.213350276027635 0.733735034040222 0.564102564102564 15.3 15 3 abnormal lymph node morphology 0.0508545081193812 0.162492728255569 0.731650559511699 0.5625 15.3 15 3 abnormal crypts of Lieberkuhn morphology 0.100539767346578 0.258493717079702 0.731650559511699 0.5625 15.3 15 3 polydipsia 0.100539767346578 0.258493717079702 0.731650559511699 0.5625 15.3 15 3 abnormal mouth morphology 0.216997647549902 0.423078463165666 0.731650559511699 0.5625 15.3 15 3 large intestinal inflammation 0.216997647549902 0.423078463165666 0.731650559511699 0.5625 15.3 15 3 abnormal epididymis epithelium morphology 0.216997647549902 0.423078463165666 0.731650559511699 0.5625 15.3 15 3 abnormal level of surface class II molecules 0.216997647549902 0.423078463165666 0.731650559511699 0.5625 15.3 15 3 abnormal Langerhans cell physiology 0.216997647549902 0.423078463165666 0.731650559511699 0.5625 15.3 15 3 decreased circulating triiodothyronine level 0.216997647549902 0.423078463165666 0.731650559511699 0.5625 15.3 15 3 decreased midbrain size 0.216997647549902 0.423078463165666 0.731650559511699 0.5625 15.3 15 3 abnormal feces composition 0.144037806557248 0.335481314429919 0.728398779247203 0.56 15.3 15 3 decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 0.144037806557248 0.335481314429919 0.728398779247203 0.56 15.3 15 3 increased B cell proliferation 0.0363216406194352 0.124192551258893 0.727516940531407 0.559322033898305 15.3 15 3 abnormal retinal photoreceptor morphology 0.0993147898803873 0.256937638926119 0.726868529710969 0.558823529411765 15.3 15 3 thin skin 0.0993147898803873 0.256937638926119 0.726868529710969 0.558823529411765 15.3 15 3 increased susceptibility to weight gain 0.0993147898803873 0.256937638926119 0.726868529710969 0.558823529411765 15.3 15 3 abnormal response to infection 0.0190848103170824 0.0773183479865512 0.724447248799207 0.556962025316456 15.3 15 3 short femur 0.0139961462407167 0.0635317769594575 0.724260149819661 0.556818181818182 15.3 15 3 abnormal systemic arterial blood pressure 0.0979833073559009 0.253889038591462 0.722617836554764 0.555555555555556 15.3 15 3 abnormal radius morphology 0.211942002132981 0.423078463165666 0.722617836554764 0.555555555555556 15.3 15 3 blepharoptosis 0.211942002132981 0.423078463165666 0.722617836554764 0.555555555555556 15.3 15 3 eye inflammation 0.211942002132981 0.423078463165666 0.722617836554764 0.555555555555556 15.3 15 3 abnormal neutrophil morphology 0.211942002132981 0.423078463165666 0.722617836554764 0.555555555555556 15.3 15 3 increased susceptibility to autoimmune disorder 0.211942002132981 0.423078463165666 0.722617836554764 0.555555555555556 15.3 15 3 jerky movement 0.211942002132981 0.423078463165666 0.722617836554764 0.555555555555556 15.3 15 3 renal tubular acidosis 0.342762654982283 0.578484211616071 0.722617836554764 0.555555555555556 15.3 15 3 abnormal urinary bladder urothelium morphology 0.342762654982283 0.578484211616071 0.722617836554764 0.555555555555556 15.3 15 3 synostosis 0.342762654982283 0.578484211616071 0.722617836554764 0.555555555555556 15.3 15 3 abnormal cholinergic neuron morphology 0.342762654982283 0.578484211616071 0.722617836554764 0.555555555555556 15.3 15 3 absent enteric neurons 0.342762654982283 0.578484211616071 0.722617836554764 0.555555555555556 15.3 15 3 dilated uterus 0.342762654982283 0.578484211616071 0.722617836554764 0.555555555555556 15.3 15 3 abnormal vagina epithelium morphology 0.342762654982283 0.578484211616071 0.722617836554764 0.555555555555556 15.3 15 3 wavy vibrissae 0.342762654982283 0.578484211616071 0.722617836554764 0.555555555555556 15.3 15 3 abnormal lens vesicle development 0.342762654982283 0.578484211616071 0.722617836554764 0.555555555555556 15.3 15 3 multifocal hepatic necrosis 0.342762654982283 0.578484211616071 0.722617836554764 0.555555555555556 15.3 15 3 abnormal lung volume 0.342762654982283 0.578484211616071 0.722617836554764 0.555555555555556 15.3 15 3 long gestation period 0.342762654982283 0.578484211616071 0.722617836554764 0.555555555555556 15.3 15 3 abnormal postural reflex 0.342762654982283 0.578484211616071 0.722617836554764 0.555555555555556 15.3 15 3 absent posterior semicircular canal 0.342762654982283 0.578484211616071 0.722617836554764 0.555555555555556 15.3 15 3 abnormal lens capsule morphology 0.342762654982283 0.578484211616071 0.722617836554764 0.555555555555556 15.3 15 3 priapism 0.342762654982283 0.578484211616071 0.722617836554764 0.555555555555556 15.3 15 3 abnormal bony labyrinth 0.342762654982283 0.578484211616071 0.722617836554764 0.555555555555556 15.3 15 3 abnormal stria vascularis vasculature morphology 0.342762654982283 0.578484211616071 0.722617836554764 0.555555555555556 15.3 15 3 abnormal oxygen consumption 0.342762654982283 0.578484211616071 0.722617836554764 0.555555555555556 15.3 15 3 decreased susceptibility to atherosclerosis 0.342762654982283 0.578484211616071 0.722617836554764 0.555555555555556 15.3 15 3 abnormal optic chiasm morphology 0.342762654982283 0.578484211616071 0.722617836554764 0.555555555555556 15.3 15 3 prolonged RR interval 0.342762654982283 0.578484211616071 0.722617836554764 0.555555555555556 15.3 15 3 decreased susceptibility to parasitic infection induced morbidity/mortality 0.342762654982283 0.578484211616071 0.722617836554764 0.555555555555556 15.3 15 3 abnormal pulmonary alveolar system morphology 0.342762654982283 0.578484211616071 0.722617836554764 0.555555555555556 15.3 15 3 abnormal pulmonary alveolar parenchyma morphology 0.342762654982283 0.578484211616071 0.722617836554764 0.555555555555556 15.3 15 3 decreased airway resistance 0.342762654982283 0.578484211616071 0.722617836554764 0.555555555555556 15.3 15 3 increased core body temperature 0.342762654982283 0.578484211616071 0.722617836554764 0.555555555555556 15.3 15 3 decreased pancreatic beta cell proliferation 0.342762654982283 0.578484211616071 0.722617836554764 0.555555555555556 15.3 15 3 abnormal ductus venosus valve topology 0.342762654982283 0.578484211616071 0.722617836554764 0.555555555555556 15.3 15 3 decreased fatty acid oxidation 0.342762654982283 0.578484211616071 0.722617836554764 0.555555555555556 15.3 15 3 enhanced leukocyte tethering or rolling 0.342762654982283 0.578484211616071 0.722617836554764 0.555555555555556 15.3 15 3 adipose tissue inflammation 0.342762654982283 0.578484211616071 0.722617836554764 0.555555555555556 15.3 15 3 altered response to myocardial infarction 0.0691335122580237 0.2079439077894 0.722617836554764 0.555555555555556 15.3 15 3 abnormal trigeminal ganglion morphology 0.141652763624832 0.33353609945258 0.722617836554764 0.555555555555556 15.3 15 3 abnormal urine homeostasis 0.0135020076791552 0.0614008118864692 0.718101475076297 0.552083333333333 15.3 15 3 abnormal circulating glucose level 0.13914885501766 0.329023552144896 0.71763426526818 0.551724137931034 15.3 15 3 decreased granulocyte number 0.13914885501766 0.329023552144896 0.71763426526818 0.551724137931034 15.3 15 3 decreased retinal photoreceptor cell number 0.13914885501766 0.329023552144896 0.71763426526818 0.551724137931034 15.3 15 3 polychromatophilia 0.13914885501766 0.329023552144896 0.71763426526818 0.551724137931034 15.3 15 3 small gonad 0.206814535777909 0.422027200777316 0.715391658189217 0.55 15.3 15 3 abnormal physiological neovascularization 0.206814535777909 0.422027200777316 0.715391658189217 0.55 15.3 15 3 absent mature ovarian follicles 0.136567427515939 0.323688876556358 0.713293735437929 0.548387096774194 15.3 15 3 abnormal CD8-positive, alpha beta T cell morphology 0.136567427515939 0.323688876556358 0.713293735437929 0.548387096774194 15.3 15 3 abnormal T cell proliferation 0.136567427515939 0.323688876556358 0.713293735437929 0.548387096774194 15.3 15 3 decreased inflammatory response 0.0242497484784212 0.0943994512364208 0.712294724603982 0.547619047619048 15.3 15 3 decreased IgM level 0.017357177487213 0.0717208953479108 0.71069836708582 0.54639175257732 15.3 15 3 decreased systemic arterial blood pressure 0.133939374190237 0.317914306582265 0.709479330435587 0.545454545454545 15.3 15 3 abnormal T cell subpopulation ratio 0.133939374190237 0.317914306582265 0.709479330435587 0.545454545454545 15.3 15 3 abnormal cytokine secretion 0.00361626471013528 0.0212407519869221 0.709479330435587 0.545454545454545 15.3 15 3 abnormal photoreceptor outer segment morphology 0.0920190105600219 0.240198758942252 0.709479330435587 0.545454545454545 15.3 15 3 parakeratosis 0.20169479950208 0.412256215087448 0.709479330435587 0.545454545454545 15.3 15 3 abnormal retinal layer morphology 0.20169479950208 0.412256215087448 0.709479330435587 0.545454545454545 15.3 15 3 decreased circulating estradiol level 0.20169479950208 0.412256215087448 0.709479330435587 0.545454545454545 15.3 15 3 abnormal occipital bone morphology 0.20169479950208 0.412256215087448 0.709479330435587 0.545454545454545 15.3 15 3 abnormal ear position 0.328001325680681 0.578484211616071 0.709479330435587 0.545454545454545 15.3 15 3 increased mast cell number 0.328001325680681 0.578484211616071 0.709479330435587 0.545454545454545 15.3 15 3 abnormal stomach epithelium morphology 0.328001325680681 0.578484211616071 0.709479330435587 0.545454545454545 15.3 15 3 abnormal larynx morphology 0.328001325680681 0.578484211616071 0.709479330435587 0.545454545454545 15.3 15 3 impaired luteinization 0.328001325680681 0.578484211616071 0.709479330435587 0.545454545454545 15.3 15 3 abnormal nerve fiber response 0.328001325680681 0.578484211616071 0.709479330435587 0.545454545454545 15.3 15 3 pathological neovascularization 0.328001325680681 0.578484211616071 0.709479330435587 0.545454545454545 15.3 15 3 abnormal coronal suture morphology 0.328001325680681 0.578484211616071 0.709479330435587 0.545454545454545 15.3 15 3 cyclopia 0.328001325680681 0.578484211616071 0.709479330435587 0.545454545454545 15.3 15 3 increased motor neuron number 0.328001325680681 0.578484211616071 0.709479330435587 0.545454545454545 15.3 15 3 abnormal dorsal-ventral polarity of the somites 0.328001325680681 0.578484211616071 0.709479330435587 0.545454545454545 15.3 15 3 abnormal aorta smooth muscle morphology 0.328001325680681 0.578484211616071 0.709479330435587 0.545454545454545 15.3 15 3 increased number of Howell-Jolly bodies 0.328001325680681 0.578484211616071 0.709479330435587 0.545454545454545 15.3 15 3 abnormal extraembryonic ectoderm morphology 0.328001325680681 0.578484211616071 0.709479330435587 0.545454545454545 15.3 15 3 abnormal phrenic nerve innervation pattern to diaphragm 0.328001325680681 0.578484211616071 0.709479330435587 0.545454545454545 15.3 15 3 hypolactation 0.328001325680681 0.578484211616071 0.709479330435587 0.545454545454545 15.3 15 3 decreased susceptibility to induced arthritis 0.0634699371388771 0.192891226185653 0.707404829469401 0.543859649122807 15.3 15 3 abnormal intestinal goblet cell morphology 0.131287998434642 0.317678630996204 0.706100857433513 0.542857142857143 15.3 15 3 increased T cell proliferation 0.0162571074917287 0.0679656384633197 0.705058898470256 0.542056074766355 15.3 15 3 curly vibrissae 0.196631726929834 0.402734805053901 0.704552390640895 0.541666666666667 15.3 15 3 abnormal male meiosis 0.0614375591032628 0.186828763165484 0.703663926087754 0.540983606557377 15.3 15 3 abnormal pancreatic beta cell physiology 0.12863100445798 0.312317836592705 0.703087624755987 0.540540540540541 15.3 15 3 increased vascular permeability 0.125981907957492 0.306035152386974 0.700383441583848 0.538461538461538 15.3 15 3 small seminal vesicle 0.191655585039463 0.392866310494986 0.700383441583848 0.538461538461538 15.3 15 3 abnormal ocular fundus morphology 0.191655585039463 0.392866310494986 0.700383441583848 0.538461538461538 15.3 15 3 abnormal tectorial membrane morphology 0.191655585039463 0.392866310494986 0.700383441583848 0.538461538461538 15.3 15 3 absent myocardial trabeculae 0.314700227710161 0.565414818655851 0.700383441583848 0.538461538461538 15.3 15 3 tight skin 0.314700227710161 0.565414818655851 0.700383441583848 0.538461538461538 15.3 15 3 abnormal digestion 0.314700227710161 0.565414818655851 0.700383441583848 0.538461538461538 15.3 15 3 increased circulating adrenocorticotropin level 0.314700227710161 0.565414818655851 0.700383441583848 0.538461538461538 15.3 15 3 abnormal intercostal muscle morphology 0.314700227710161 0.565414818655851 0.700383441583848 0.538461538461538 15.3 15 3 abnormal bile duct development 0.314700227710161 0.565414818655851 0.700383441583848 0.538461538461538 15.3 15 3 abnormal soleus morphology 0.314700227710161 0.565414818655851 0.700383441583848 0.538461538461538 15.3 15 3 anal atresia 0.314700227710161 0.565414818655851 0.700383441583848 0.538461538461538 15.3 15 3 increased circulating ammonia level 0.314700227710161 0.565414818655851 0.700383441583848 0.538461538461538 15.3 15 3 decreased cardiac stroke volume 0.314700227710161 0.565414818655851 0.700383441583848 0.538461538461538 15.3 15 3 increased sensitivity to induced morbidity/mortality 0.00298416231824411 0.0185746530946013 0.699839665619886 0.53804347826087 15.3 15 3 increased triglyceride level 0.186784899622779 0.387720944288357 0.696810056677808 0.535714285714286 15.3 15 3 gastrointestinal hemorrhage 0.18203063103597 0.387720944288357 0.693713123092574 0.533333333333333 15.3 15 3 arrested T cell differentiation 0.18203063103597 0.387720944288357 0.693713123092574 0.533333333333333 15.3 15 3 salivary gland inflammation 0.18203063103597 0.387720944288357 0.693713123092574 0.533333333333333 15.3 15 3 abnormal lactation 0.18203063103597 0.387720944288357 0.693713123092574 0.533333333333333 15.3 15 3 abnormal fat pad morphology 0.18203063103597 0.387720944288357 0.693713123092574 0.533333333333333 15.3 15 3 decreased chondrocyte number 0.302559282345466 0.545967511668006 0.693713123092574 0.533333333333333 15.3 15 3 vagina atresia 0.302559282345466 0.545967511668006 0.693713123092574 0.533333333333333 15.3 15 3 abnormal respiratory system morphology 0.302559282345466 0.545967511668006 0.693713123092574 0.533333333333333 15.3 15 3 abnormal cricoid cartilage morphology 0.302559282345466 0.545967511668006 0.693713123092574 0.533333333333333 15.3 15 3 abnormal pericyte morphology 0.302559282345466 0.545967511668006 0.693713123092574 0.533333333333333 15.3 15 3 abnormal zygomatic bone morphology 0.302559282345466 0.545967511668006 0.693713123092574 0.533333333333333 15.3 15 3 abnormal dendritic cell morphology 0.302559282345466 0.545967511668006 0.693713123092574 0.533333333333333 15.3 15 3 ostium primum atrial septal defect 0.302559282345466 0.545967511668006 0.693713123092574 0.533333333333333 15.3 15 3 abnormal coronary vessel morphology 0.302559282345466 0.545967511668006 0.693713123092574 0.533333333333333 15.3 15 3 decreased trabecular bone mass 0.302559282345466 0.545967511668006 0.693713123092574 0.533333333333333 15.3 15 3 abnormal epidermis stratum corneum morphology 0.113142686945729 0.282856935822693 0.690173770423734 0.530612244897959 15.3 15 3 decreased pancreatic beta cell number 0.172892031538817 0.387720944288357 0.688612291305128 0.529411764705882 15.3 15 3 decreased osteoblast cell number 0.172892031538817 0.387720944288357 0.688612291305128 0.529411764705882 15.3 15 3 abnormal skin physiology 0.172892031538817 0.387720944288357 0.688612291305128 0.529411764705882 15.3 15 3 aminoaciduria 0.291370763745621 0.528076338664649 0.688612291305128 0.529411764705882 15.3 15 3 abnormal inflammatory response 0.0704002059762717 0.21149820334055 0.686486944727026 0.527777777777778 15.3 15 3 impaired wound healing 0.168510888463823 0.3812376853604 0.686486944727026 0.527777777777778 15.3 15 3 irregular coat pigmentation 0.280983601326272 0.509807956454486 0.684585318841356 0.526315789473684 15.3 15 3 abnormal nail morphology 0.280983601326272 0.509807956454486 0.684585318841356 0.526315789473684 15.3 15 3 decreased susceptibility to weight gain 0.280983601326272 0.509807956454486 0.684585318841356 0.526315789473684 15.3 15 3 abnormal vibrissa morphology 0.156106566297195 0.35333492599115 0.681325388751635 0.523809523809524 15.3 15 3 hypoalgesia 0.271283694629674 0.49310792136742 0.681325388751635 0.523809523809524 15.3 15 3 increased bone ossification 0.271283694629674 0.49310792136742 0.681325388751635 0.523809523809524 15.3 15 3 abnormal dendritic cell physiology 0.0400053746429681 0.133858658050179 0.680746522660937 0.523364485981308 15.3 15 3 abnormal epidermal layer morphology 0.0906978797071405 0.238741773303187 0.678632403025344 0.521739130434783 15.3 15 3 hyperkeratosis 0.0906978797071405 0.238741773303187 0.678632403025344 0.521739130434783 15.3 15 3 abnormal lymphocyte physiology 0.148426398463496 0.341861727942544 0.678632403025344 0.521739130434783 15.3 15 3 blistering 0.262182250437717 0.477087306484141 0.678632403025344 0.521739130434783 15.3 15 3 abnormal postnatal growth 0.262182250437717 0.477087306484141 0.678632403025344 0.521739130434783 15.3 15 3 dilated heart 0.262182250437717 0.477087306484141 0.678632403025344 0.521739130434783 15.3 15 3 abnormal CD4-positive, alpha-beta T cell physiology 0.0887086060875667 0.2337528152996 0.677835886120385 0.52112676056338 15.3 15 3 abnormal digestive system physiology 0.141187188942872 0.33353609945258 0.676370295015259 0.52 15.3 15 3 abnormal keratinocyte physiology 0.253608474000137 0.46199273458465 0.676370295015259 0.52 15.3 15 3 abnormal CD8-positive, alpha-beta T cell physiology 0.237823518842549 0.43371407853434 0.672782123688918 0.517241379310345 15.3 15 3 absent vibrissae 0.22357438982038 0.423078463165666 0.670063812078054 0.515151515151515 15.3 15 3 decreased susceptibility to injury 0.113344679208595 0.282856935822693 0.669484172102208 0.514705882352941 15.3 15 3 dehydration 0.110667364643748 0.280473835508226 0.668937654410696 0.514285714285714 15.3 15 3 decreased IgG level 0.0572108652149938 0.180943454828095 0.667933243518188 0.513513513513513 15.3 15 3 increased insulin secretion 0.210606321581102 0.423078463165666 0.667933243518188 0.513513513513513 15.3 15 3 small lens 0.204541143791787 0.417730784221732 0.667031849127475 0.512820512820513 15.3 15 3 acanthosis 0.204541143791787 0.417730784221732 0.667031849127475 0.512820512820513 15.3 15 3 increased tumor growth/size 0.198728331742227 0.406861502229457 0.666218395652929 0.51219512195122 15.3 15 3 impaired macrophage phagocytosis 0.193150594064898 0.39576779467581 0.665480612269039 0.511627906976744 15.3 15 3 abnormal NK cell physiology 0.151418951584106 0.343037014631569 0.661017627536981 0.508196721311475 15.3 15 3 abnormal coat appearance 0.136657561048327 0.323748269626394 0.659781502941307 0.507246376811594 15.3 15 3 increased eosinophil cell number 0.18099641213049 0.387720944288357 0.650356052899288 0.5 15.3 15 3 abnormal kidney physiology 0.220527014862582 0.423078463165666 0.650356052899288 0.5 15.3 15 3 abnormal gametogenesis 0.234091544893958 0.427064699614024 0.650356052899288 0.5 15.3 15 3 increased susceptibility to weight loss 0.248961830189458 0.45369417772621 0.650356052899288 0.5 15.3 15 3 abnormal epidermis stratum granulosum morphology 0.265375832952065 0.482722036174231 0.650356052899288 0.5 15.3 15 3 increased susceptibility to viral infection induced morbidity/mortality 0.274256748101942 0.498329920309409 0.650356052899288 0.5 15.3 15 3 reddish skin 0.304224655041509 0.548773625392134 0.650356052899288 0.5 15.3 15 3 abnormal vasoconstriction 0.407550804461818 0.578484211616071 0.650356052899288 0.5 15.3 15 3 decreased mast cell number 0.388120917141028 0.578484211616071 0.650356052899288 0.5 15.3 15 3 abnormal zigzag hair morphology 0.407550804461818 0.578484211616071 0.650356052899288 0.5 15.3 15 3 waved hair 0.355152666874634 0.578484211616071 0.650356052899288 0.5 15.3 15 3 abnormal stomach glandular epithelium morphology 0.370799525358261 0.578484211616071 0.650356052899288 0.5 15.3 15 3 abnormal pituitary gland morphology 0.388120917141028 0.578484211616071 0.650356052899288 0.5 15.3 15 3 thick dermal layer 0.370799525358261 0.578484211616071 0.650356052899288 0.5 15.3 15 3 absent optic nerve 0.429730426802981 0.578484211616071 0.650356052899288 0.5 15.3 15 3 absent visceral yolk sac blood islands 0.407550804461818 0.578484211616071 0.650356052899288 0.5 15.3 15 3 abnormal antigen presentation 0.407550804461818 0.578484211616071 0.650356052899288 0.5 15.3 15 3 increased litter size 0.429730426802981 0.578484211616071 0.650356052899288 0.5 15.3 15 3 increased circulating parathyroid hormone level 0.429730426802981 0.578484211616071 0.650356052899288 0.5 15.3 15 3 small thyroid gland 0.429730426802981 0.578484211616071 0.650356052899288 0.5 15.3 15 3 abnormal kidney medulla morphology 0.407550804461818 0.578484211616071 0.650356052899288 0.5 15.3 15 3 decreased vascular permeability 0.407550804461818 0.578484211616071 0.650356052899288 0.5 15.3 15 3 abnormal gastrocnemius morphology 0.429730426802981 0.578484211616071 0.650356052899288 0.5 15.3 15 3 decreased skin tensile strength 0.355152666874634 0.578484211616071 0.650356052899288 0.5 15.3 15 3 small intestinal inflammation 0.429730426802981 0.578484211616071 0.650356052899288 0.5 15.3 15 3 abnormal vascular endothelial cell migration 0.407550804461818 0.578484211616071 0.650356052899288 0.5 15.3 15 3 impaired sperm capacitation 0.429730426802981 0.578484211616071 0.650356052899288 0.5 15.3 15 3 abnormal female reproductive system physiology 0.340872589757269 0.578484211616071 0.650356052899288 0.5 15.3 15 3 abnormal sagittal suture morphology 0.407550804461818 0.578484211616071 0.650356052899288 0.5 15.3 15 3 abnormal thymocyte activation 0.355152666874634 0.578484211616071 0.650356052899288 0.5 15.3 15 3 abnormal molar crown morphology 0.388120917141028 0.578484211616071 0.650356052899288 0.5 15.3 15 3 small parietal bone 0.429730426802981 0.578484211616071 0.650356052899288 0.5 15.3 15 3 abnormal positive T cell selection 0.407550804461818 0.578484211616071 0.650356052899288 0.5 15.3 15 3 increased placenta weight 0.429730426802981 0.578484211616071 0.650356052899288 0.5 15.3 15 3 kidney atrophy 0.355152666874634 0.578484211616071 0.650356052899288 0.5 15.3 15 3 abnormal wound healing 0.388120917141028 0.578484211616071 0.650356052899288 0.5 15.3 15 3 premature hair loss 0.407550804461818 0.578484211616071 0.650356052899288 0.5 15.3 15 3 decreased circulating VLDL cholesterol level 0.355152666874634 0.578484211616071 0.650356052899288 0.5 15.3 15 3 abnormal B cell proliferation 0.429730426802981 0.578484211616071 0.650356052899288 0.5 15.3 15 3 abnormal glucose tolerance 0.407550804461818 0.578484211616071 0.650356052899288 0.5 15.3 15 3 decreased oligodendrocyte number 0.429730426802981 0.578484211616071 0.650356052899288 0.5 15.3 15 3 abnormal sperm axoneme morphology 0.370799525358261 0.578484211616071 0.650356052899288 0.5 15.3 15 3 abnormal aorta elastic tissue morphology 0.429730426802981 0.578484211616071 0.650356052899288 0.5 15.3 15 3 abnormal urinary bladder physiology 0.388120917141028 0.578484211616071 0.650356052899288 0.5 15.3 15 3 decreased compensatory feeding amount 0.429730426802981 0.578484211616071 0.650356052899288 0.5 15.3 15 3 abnormal auchene hair morphology 0.455666516492099 0.602909819028775 0.650356052899288 0.5 15.3 15 3 kidney hemorrhage 0.455666516492099 0.602909819028775 0.650356052899288 0.5 15.3 15 3 abnormal epidermis suprabasal layer morphology 0.455666516492099 0.602909819028775 0.650356052899288 0.5 15.3 15 3 abnormal pituitary secretion 0.455666516492099 0.602909819028775 0.650356052899288 0.5 15.3 15 3 abnormal neuron specification 0.455666516492099 0.602909819028775 0.650356052899288 0.5 15.3 15 3 delayed dark adaptation 0.455666516492099 0.602909819028775 0.650356052899288 0.5 15.3 15 3 rickets 0.455666516492099 0.602909819028775 0.650356052899288 0.5 15.3 15 3 intestinal edema 0.455666516492099 0.602909819028775 0.650356052899288 0.5 15.3 15 3 lymphedema 0.455666516492099 0.602909819028775 0.650356052899288 0.5 15.3 15 3 increased left ventricle diastolic pressure 0.455666516492099 0.602909819028775 0.650356052899288 0.5 15.3 15 3 increased defecation amount 0.455666516492099 0.602909819028775 0.650356052899288 0.5 15.3 15 3 ascites 0.455666516492099 0.602909819028775 0.650356052899288 0.5 15.3 15 3 increased susceptibility to atherosclerosis 0.455666516492099 0.602909819028775 0.650356052899288 0.5 15.3 15 3 decreased thyroxine level 0.455666516492099 0.602909819028775 0.650356052899288 0.5 15.3 15 3 absent axillary lymph nodes 0.455666516492099 0.602909819028775 0.650356052899288 0.5 15.3 15 3 abnormal retinal blood vessel pattern 0.455666516492099 0.602909819028775 0.650356052899288 0.5 15.3 15 3 abnormal vibrissa follicle morphology 0.455666516492099 0.602909819028775 0.650356052899288 0.5 15.3 15 3 abnormal adaptive thermogenesis 0.455666516492099 0.602909819028775 0.650356052899288 0.5 15.3 15 3 decreased macrophage cytokine production 0.455666516492099 0.602909819028775 0.650356052899288 0.5 15.3 15 3 decreased monocyte cell number 0.207546547114562 0.423078463165666 0.640350575162376 0.492307692307692 15.3 15 3 abnormal coat/ hair morphology 0.246396016625127 0.449182917812389 0.63808518397666 0.490566037735849 15.3 15 3 abnormal intestinal mucosa morphology 0.287358713804058 0.521184688725917 0.635231493529537 0.488372093023256 15.3 15 3 abnormal leukocyte adhesion 0.30675457300441 0.553136643964095 0.633680256671101 0.487179487179487 15.3 15 3 diarrhea 0.340193020041062 0.578484211616071 0.630648293720522 0.484848484848485 15.3 15 3 abnormal immune system physiology 0.154594618211834 0.350072018936676 0.629376825386408 0.483870967741935 15.3 15 3 focal hair loss 0.366199048827205 0.578484211616071 0.627929982109657 0.482758620689655 15.3 15 3 enlarged epididymis 0.366199048827205 0.578484211616071 0.627929982109657 0.482758620689655 15.3 15 3 abnormal hair growth 0.296242889798015 0.536515608571214 0.625342358557008 0.480769230769231 15.3 15 3 increased susceptibility to injury 0.296242889798015 0.536515608571214 0.625342358557008 0.480769230769231 15.3 15 3 abnormal immune system morphology 0.325328319763938 0.578484211616071 0.622079702773232 0.478260869565217 15.3 15 3 abnormal retinal cone cell morphology 0.413005400800192 0.578484211616071 0.622079702773232 0.478260869565217 15.3 15 3 hypotension 0.413005400800192 0.578484211616071 0.622079702773232 0.478260869565217 15.3 15 3 decreased epididymis weight 0.413005400800192 0.578484211616071 0.622079702773232 0.478260869565217 15.3 15 3 abnormal regulatory T cell physiology 0.413005400800192 0.578484211616071 0.622079702773232 0.478260869565217 15.3 15 3 increased susceptibility to fungal infection 0.413005400800192 0.578484211616071 0.622079702773232 0.478260869565217 15.3 15 3 abnormal humoral immune response 0.222721335846885 0.423078463165666 0.619386717046941 0.476190476190476 15.3 15 3 increased incidence of induced tumors 0.431397187097326 0.578484211616071 0.619386717046941 0.476190476190476 15.3 15 3 dry skin 0.431397187097326 0.578484211616071 0.619386717046941 0.476190476190476 15.3 15 3 abnormal cytotoxic T cell physiology 0.347215221004603 0.578484211616071 0.619386717046941 0.476190476190476 15.3 15 3 decreased circulating phosphate level 0.359043245075081 0.578484211616071 0.617838250254323 0.475 15.3 15 3 decreased germ cell number 0.451633856987051 0.600609045311569 0.61612678695722 0.473684210526316 15.3 15 3 abnormal neural crest cell migration 0.451633856987051 0.600609045311569 0.61612678695722 0.473684210526316 15.3 15 3 abnormal T cell activation 0.290623138898117 0.526913307586783 0.615201671661489 0.472972972972973 15.3 15 3 decreased regulatory T cell number 0.398803039542502 0.578484211616071 0.612099814493447 0.470588235294118 15.3 15 3 abnormal tendon morphology 0.474121053492502 0.626661062998193 0.612099814493447 0.470588235294118 15.3 15 3 abnormal circulating chemokine level 0.474121053492502 0.626661062998193 0.612099814493447 0.470588235294118 15.3 15 3 abnormal estrous cycle 0.429708860733024 0.578484211616071 0.606998982706002 0.466666666666667 15.3 15 3 joint inflammation 0.499418386313626 0.653843808397444 0.606998982706002 0.466666666666667 15.3 15 3 decreased circulating progesterone level 0.446817924913893 0.594522379365236 0.603902049120767 0.464285714285714 15.3 15 3 increased neutrophil cell number 0.279017958378394 0.506796036119938 0.6010186971621 0.462068965517241 15.3 15 3 abnormal lens fiber morphology 0.427064320618634 0.578484211616071 0.600328664214727 0.461538461538462 15.3 15 3 abnormal leukocyte cell number 0.465235640410495 0.615243836002715 0.600328664214727 0.461538461538462 15.3 15 3 decreased Peyer's patch number 0.465235640410495 0.615243836002715 0.600328664214727 0.461538461538462 15.3 15 3 abnormal membranous labyrinth morphology 0.528327740311112 0.680764182348558 0.600328664214727 0.461538461538462 15.3 15 3 abnormal renal/urinary system morphology 0.528327740311112 0.680764182348558 0.600328664214727 0.461538461538462 15.3 15 3 uterus hypoplasia 0.528327740311112 0.680764182348558 0.600328664214727 0.461538461538462 15.3 15 3 increased circulating thyroid-stimulating hormone level 0.528327740311112 0.680764182348558 0.600328664214727 0.461538461538462 15.3 15 3 decreased follicle stimulating hormone level 0.528327740311112 0.680764182348558 0.600328664214727 0.461538461538462 15.3 15 3 increased renin activity 0.528327740311112 0.680764182348558 0.600328664214727 0.461538461538462 15.3 15 3 abnormal hair follicle inner root sheath morphology 0.528327740311112 0.680764182348558 0.600328664214727 0.461538461538462 15.3 15 3 increased susceptibility to bacterial infection induced morbidity/mortality 0.385403448245711 0.578484211616071 0.596159715157681 0.458333333333333 15.3 15 3 abnormal hair shaft morphology 0.424097165212156 0.578484211616071 0.596159715157681 0.458333333333333 15.3 15 3 abnormal vasodilation 0.485159161984848 0.63801850792689 0.596159715157681 0.458333333333333 15.3 15 3 small lymph nodes 0.485159161984848 0.63801850792689 0.596159715157681 0.458333333333333 15.3 15 3 intestinal ulcer 0.506834351547373 0.663029423862262 0.591232775362989 0.454545454545455 15.3 15 3 increased activated T cell number 0.506834351547373 0.663029423862262 0.591232775362989 0.454545454545455 15.3 15 3 abnormal circulating lipid level 0.506834351547373 0.663029423862262 0.591232775362989 0.454545454545455 15.3 15 3 abnormal awl hair morphology 0.562054175501614 0.721418865614171 0.591232775362989 0.454545454545455 15.3 15 3 abnormal food preference 0.562054175501614 0.721418865614171 0.591232775362989 0.454545454545455 15.3 15 3 retinal detachment 0.562054175501614 0.721418865614171 0.591232775362989 0.454545454545455 15.3 15 3 patent ductus arteriosus 0.562054175501614 0.721418865614171 0.591232775362989 0.454545454545455 15.3 15 3 rectal hemorrhage 0.562054175501614 0.721418865614171 0.591232775362989 0.454545454545455 15.3 15 3 abnormal hair medulla 0.562054175501614 0.721418865614171 0.591232775362989 0.454545454545455 15.3 15 3 enlarged placenta 0.562054175501614 0.721418865614171 0.591232775362989 0.454545454545455 15.3 15 3 autoimmune response 0.49307450199963 0.64570825149991 0.587418370360647 0.451612903225806 15.3 15 3 abnormal fibula morphology 0.530573012533573 0.68330332315675 0.585320447609359 0.45 15.3 15 3 abnormal Peyer's patch T cell area morphology 0.530573012533573 0.68330332315675 0.585320447609359 0.45 15.3 15 3 stomach inflammation 0.512320761734327 0.670030438913848 0.583077840530396 0.448275862068966 15.3 15 3 wrinkled skin 0.532933027331805 0.686165064952312 0.578094269243811 0.444444444444444 15.3 15 3 acidosis 0.556778275999894 0.715940016308988 0.578094269243811 0.444444444444444 15.3 15 3 decreased heart rate variability 0.556778275999894 0.715940016308988 0.578094269243811 0.444444444444444 15.3 15 3 decreased cytotoxic T cell cytolysis 0.535233896171227 0.688949193648604 0.573843576087607 0.441176470588235 15.3 15 3 abnormal intestinal epithelium morphology 0.539546681586407 0.694320936599166 0.569061546286877 0.4375 15.3 15 3 mixed cellular infiltration to dermis 0.585983084558979 0.731743435160874 0.569061546286877 0.4375 15.3 15 3 sepsis 0.585983084558979 0.731743435160874 0.569061546286877 0.4375 15.3 15 3 increased susceptibility to parasitic infection 0.550520052483237 0.708258924516189 0.563641912512716 0.433333333333333 15.3 15 3 increased circulating luteinizing hormone level 0.597519354145239 0.745962054422225 0.557448045342247 0.428571428571429 15.3 15 3 increased vasoconstriction 0.604954881610759 0.752600784199431 0.557448045342247 0.428571428571429 15.3 15 3 decreased IgA level 0.618830144340225 0.769669992023154 0.550301275530167 0.423076923076923 15.3 15 3 flaky skin 0.633246944372871 0.78701062909194 0.547668255073085 0.421052631578947 15.3 15 3 altered susceptibility to infection 0.633246944372871 0.78701062909194 0.547668255073085 0.421052631578947 15.3 15 3 decreased liver glycogen level 0.633246944372871 0.78701062909194 0.547668255073085 0.421052631578947 15.3 15 3 abnormal anogenital distance 0.65657113885778 0.789944550078591 0.541963377416073 0.416666666666667 15.3 15 3 enlarged sebaceous gland 0.664286506305513 0.789944550078591 0.535587337681767 0.411764705882353 15.3 15 3 decreased susceptibility to viral infection induced morbidity/mortality 0.672884479346949 0.789944550078591 0.53210949782669 0.409090909090909 15.3 15 3 decreased susceptibility to parasitic infection 0.689926203941327 0.800835946012157 0.528414292980671 0.40625 15.3 15 3 abnormal leukocyte migration 0.720296400811732 0.826066065937843 0.525287581187886 0.403846153846154 15.3 15 3 abnormal stomach mucosa morphology 0.706684628689119 0.818760136872 0.52028484231943 0.4 15.3 15 3 greasy coat 0.698571812787721 0.810682241338677 0.52028484231943 0.4 15.3 15 3 nuclear cataracts 0.701696232265737 0.81316998731005 0.52028484231943 0.4 15.3 15 3 delayed wound healing 0.769939253791179 0.877737806510339 0.508974302269008 0.391304347826087 15.3 15 3 abnormal iron level 0.732700834681816 0.839904758650239 0.505832485588335 0.388888888888889 15.3 15 3 abnormal macrophage chemotaxis 0.732700834681816 0.839904758650239 0.505832485588335 0.388888888888889 15.3 15 3 abnormal intestine physiology 0.761330505460039 0.868720014831122 0.503501460309126 0.387096774193548 15.3 15 3 impaired natural killer cell mediated cytotoxicity 0.808968394014284 0.90761113340237 0.502029233816994 0.385964912280702 15.3 15 3 abnormal mast cell morphology 0.736723262949447 0.844321177879176 0.500273886845606 0.384615384615385 15.3 15 3 increased acute inflammation 0.761229371130339 0.868720014831122 0.495509373637553 0.380952380952381 15.3 15 3 abnormal bile salt homeostasis 0.761229371130339 0.868720014831122 0.495509373637553 0.380952380952381 15.3 15 3 increased susceptibility to induced arthritis 0.783671102658195 0.892369818201995 0.493373557371874 0.379310344827586 15.3 15 3 abnormal intestinal absorption 0.766125049724966 0.873589759885791 0.487767039674466 0.375 15.3 15 3 increased circulating estradiol level 0.766125049724966 0.873589759885791 0.487767039674466 0.375 15.3 15 3 abnormal pancreatic alpha cell morphology 0.766125049724966 0.873589759885791 0.487767039674466 0.375 15.3 15 3 decreased acute inflammation 0.829900872666234 0.917705454882089 0.468256358087487 0.36 15.3 15 3 abnormal spleen periarteriolar lymphoid sheath morphology 0.802174830033539 0.90761113340237 0.464540037785206 0.357142857142857 15.3 15 3 abnormal hair cuticle 0.802174830033539 0.90761113340237 0.464540037785206 0.357142857142857 15.3 15 3 increased B-1 B cell number 0.802174830033539 0.90761113340237 0.464540037785206 0.357142857142857 15.3 15 3 abnormal respiratory motile cilium physiology 0.802174830033539 0.90761113340237 0.464540037785206 0.357142857142857 15.3 15 3 abnormal spleen germinal center morphology 0.845825681131648 0.934276812528852 0.464540037785206 0.357142857142857 15.3 15 3 decreased susceptibility to bacterial infection induced morbidity/mortality 0.859882398688232 0.949381920433634 0.461543005283366 0.354838709677419 15.3 15 3 nephrocalcinosis 0.821673346135576 0.910023351964491 0.459074860870086 0.352941176470588 15.3 15 3 increased urine calcium level 0.838649111901065 0.926967192114596 0.455249237029501 0.35 15.3 15 3 abnormal circulating cytokine level 0.838649111901065 0.926967192114596 0.455249237029501 0.35 15.3 15 3 lactation failure 0.853976338656448 0.943070429481871 0.433570701932859 0.333333333333333 15.3 15 3 impaired leukocyte tethering or rolling 0.866159601862457 0.956100292714826 0.433570701932859 0.333333333333333 15.3 15 3 abnormal cellular extravasation 0.887580823673905 0.977144190700969 0.433570701932859 0.333333333333333 15.3 15 3 decreased airway responsiveness 0.907994163017033 0.989544569772122 0.413862942754092 0.318181818181818 15.3 15 3 abnormal brainstem morphology 5.99968193061095e-08 1.06222126707436e-06 0.810438680755684 1 15.1 15 1 abnormal trigeminal ganglion morphology 1.0869072652553e-07 1.80848282429603e-06 0.810438680755684 1 15.1 15 1 abnormal pulmonary artery morphology 1.17043035954749e-06 1.55692273763337e-05 0.810438680755684 1 15.1 15 1 abnormal embryonic/fetal subventricular zone morphology 3.84025223558269e-06 4.54887020762474e-05 0.810438680755684 1 15.1 15 1 absent segment of posterior cerebral artery 3.84025223558269e-06 4.54887020762474e-05 0.810438680755684 1 15.1 15 1 abnormal basioccipital bone morphology 6.95586664147857e-06 7.73531592330232e-05 0.810438680755684 1 15.1 15 1 decreased paired-pulse facilitation 6.95586664147857e-06 7.73531592330232e-05 0.810438680755684 1 15.1 15 1 abnormal postnatal subventricular zone morphology 6.95586664147857e-06 7.73531592330232e-05 0.810438680755684 1 15.1 15 1 increased skin tumor incidence 6.95586664147857e-06 7.73531592330232e-05 0.810438680755684 1 15.1 15 1 translucent skin 0.000245517257185478 0.00178835776646816 0.810438680755684 1 15.1 15 1 absent olfactory bulb 0.000245517257185478 0.00178835776646816 0.810438680755684 1 15.1 15 1 split sternum 0.000245517257185478 0.00178835776646816 0.810438680755684 1 15.1 15 1 lysosomal protein accumulation 0.000245517257185478 0.00178835776646816 0.810438680755684 1 15.1 15 1 abnormal renal tubule epithelial cell primary cilium morphology 0.000245517257185478 0.00178835776646816 0.810438680755684 1 15.1 15 1 testis degeneration 0.000245517257185478 0.00178835776646816 0.810438680755684 1 15.1 15 1 multiple persisting craniopharyngeal ducts 0.000245517257185478 0.00178835776646816 0.810438680755684 1 15.1 15 1 abnormal vitelline vein topology 0.000245517257185478 0.00178835776646816 0.810438680755684 1 15.1 15 1 abnormal thymus involution 0.000805210035022177 0.00500739990529416 0.810438680755684 1 15.1 15 1 abnormal corticospinal tract morphology 0.000805210035022177 0.00500739990529416 0.810438680755684 1 15.1 15 1 abnormal AMPA-mediated synaptic currents 0.000805210035022177 0.00500739990529416 0.810438680755684 1 15.1 15 1 dilated bile duct 0.000805210035022177 0.00500739990529416 0.810438680755684 1 15.1 15 1 abnormal rostral-caudal body axis extension 0.000805210035022177 0.00500739990529416 0.810438680755684 1 15.1 15 1 pale placenta 0.000805210035022177 0.00500739990529416 0.810438680755684 1 15.1 15 1 decreased red blood cell distribution width 0.000805210035022177 0.00500739990529416 0.810438680755684 1 15.1 15 1 abnormal pulmonary valve cusp morphology 0.000805210035022177 0.00500739990529416 0.810438680755684 1 15.1 15 1 embryonic lethality between implantation and placentation, incomplete penetrance 0.000805210035022177 0.00500739990529416 0.810438680755684 1 15.1 15 1 abnormal vitelline vein connection 0.000805210035022177 0.00500739990529416 0.810438680755684 1 15.1 15 1 premature suture closure 0.00145816670677135 0.00830971290514029 0.810438680755684 1 15.1 15 1 enlarged cranium 0.00145816670677135 0.00830971290514029 0.810438680755684 1 15.1 15 1 failure of somite differentiation 0.00145816670677135 0.00830971290514029 0.810438680755684 1 15.1 15 1 abnormal proximal-distal axis patterning 0.00145816670677135 0.00830971290514029 0.810438680755684 1 15.1 15 1 abnormal fear/anxiety-related behavior 0.00145816670677135 0.00830971290514029 0.810438680755684 1 15.1 15 1 abnormal vestibular ganglion morphology 0.00145816670677135 0.00830971290514029 0.810438680755684 1 15.1 15 1 fatigue 0.00145816670677135 0.00830971290514029 0.810438680755684 1 15.1 15 1 abnormal radial glial cell morphology 0.00145816670677135 0.00830971290514029 0.810438680755684 1 15.1 15 1 pharyngeal arch hypoplasia 0.00145816670677135 0.00830971290514029 0.810438680755684 1 15.1 15 1 increased glycogen level 0.00145816670677135 0.00830971290514029 0.810438680755684 1 15.1 15 1 abnormal palatal shelf elevation 0.00145816670677135 0.00830971290514029 0.810438680755684 1 15.1 15 1 thin hypoglossal nerve 0.00145816670677135 0.00830971290514029 0.810438680755684 1 15.1 15 1 reduced sympathetic cervical ganglion size 0.00145816670677135 0.00830971290514029 0.810438680755684 1 15.1 15 1 increased cranium width 0.00264055241848802 0.0137632821266244 0.810438680755684 1 15.1 15 1 acrania 0.00264055241848802 0.0137632821266244 0.810438680755684 1 15.1 15 1 intestinal hypoperistalsis 0.00264055241848802 0.0137632821266244 0.810438680755684 1 15.1 15 1 abnormal hypaxial muscle morphology 0.00264055241848802 0.0137632821266244 0.810438680755684 1 15.1 15 1 increased atrioventricular cushion size 0.00264055241848802 0.0137632821266244 0.810438680755684 1 15.1 15 1 increased heart rate variability 0.00264055241848802 0.0137632821266244 0.810438680755684 1 15.1 15 1 abnormal plasma membrane morphology 0.00264055241848802 0.0137632821266244 0.810438680755684 1 15.1 15 1 abnormal deltoid tuberosity morphology 0.00264055241848802 0.0137632821266244 0.810438680755684 1 15.1 15 1 abnormal respiratory conducting tube morphology 0.00264055241848802 0.0137632821266244 0.810438680755684 1 15.1 15 1 osteosclerosis 0.00264055241848802 0.0137632821266244 0.810438680755684 1 15.1 15 1 abnormal spinal cord dorsal column morphology 0.00264055241848802 0.0137632821266244 0.810438680755684 1 15.1 15 1 ventricular premature beat 0.00264055241848802 0.0137632821266244 0.810438680755684 1 15.1 15 1 abnormal hippocampus neuron morphology 0.00264055241848802 0.0137632821266244 0.810438680755684 1 15.1 15 1 increased circulating fructosamine level 0.00264055241848802 0.0137632821266244 0.810438680755684 1 15.1 15 1 abnormal left subclavian artery morphology 0.00264055241848802 0.0137632821266244 0.810438680755684 1 15.1 15 1 abnormal inferior vena cava valve morphology 0.00264055241848802 0.0137632821266244 0.810438680755684 1 15.1 15 1 thin ventricle myocardium compact layer 0.00264055241848802 0.0137632821266244 0.810438680755684 1 15.1 15 1 increased fatty acid oxidation 0.00264055241848802 0.0137632821266244 0.810438680755684 1 15.1 15 1 broad head 0.0156781690076787 0.0583824033032945 0.810438680755684 1 15.1 15 1 absent hair follicles 0.0156781690076787 0.0583824033032945 0.810438680755684 1 15.1 15 1 polyphalangy 0.0156781690076787 0.0583824033032945 0.810438680755684 1 15.1 15 1 maxilla hypoplasia 0.0156781690076787 0.0583824033032945 0.810438680755684 1 15.1 15 1 absent epidermis stratum corneum 0.0156781690076787 0.0583824033032945 0.810438680755684 1 15.1 15 1 excessive tearing 0.0156781690076787 0.0583824033032945 0.810438680755684 1 15.1 15 1 abnormal circulating alanine transaminase level 0.0156781690076787 0.0583824033032945 0.810438680755684 1 15.1 15 1 abnormal melanocyte morphology 0.0156781690076787 0.0583824033032945 0.810438680755684 1 15.1 15 1 abnormal inhibitory postsynaptic potential 0.0156781690076787 0.0583824033032945 0.810438680755684 1 15.1 15 1 decreased mortality induced by ionizing radiation 0.0156781690076787 0.0583824033032945 0.810438680755684 1 15.1 15 1 absent tunnel of Corti 0.0156781690076787 0.0583824033032945 0.810438680755684 1 15.1 15 1 decreased cardiomyocyte apoptosis 0.0156781690076787 0.0583824033032945 0.810438680755684 1 15.1 15 1 abnormal sinus venosus morphology 0.0156781690076787 0.0583824033032945 0.810438680755684 1 15.1 15 1 aorta coarctation 0.0156781690076787 0.0583824033032945 0.810438680755684 1 15.1 15 1 anuria 0.0156781690076787 0.0583824033032945 0.810438680755684 1 15.1 15 1 increased cell nucleus count 0.0156781690076787 0.0583824033032945 0.810438680755684 1 15.1 15 1 abnormal central pattern generator function 0.0156781690076787 0.0583824033032945 0.810438680755684 1 15.1 15 1 abnormal Purkinje cell innervation 0.0156781690076787 0.0583824033032945 0.810438680755684 1 15.1 15 1 abnormal optic tract morphology 0.0156781690076787 0.0583824033032945 0.810438680755684 1 15.1 15 1 abnormal cochlear nerve compound action potential 0.0156781690076787 0.0583824033032945 0.810438680755684 1 15.1 15 1 absent thyroid gland 0.0156781690076787 0.0583824033032945 0.810438680755684 1 15.1 15 1 absent fibula 0.0156781690076787 0.0583824033032945 0.810438680755684 1 15.1 15 1 retinal pigment epithelium atrophy 0.0156781690076787 0.0583824033032945 0.810438680755684 1 15.1 15 1 heart hemorrhage 0.0156781690076787 0.0583824033032945 0.810438680755684 1 15.1 15 1 postaxial polydactyly 0.0156781690076787 0.0583824033032945 0.810438680755684 1 15.1 15 1 decreased behavioral withdrawal response 0.0156781690076787 0.0583824033032945 0.810438680755684 1 15.1 15 1 decreased DN2 thymocyte number 0.0156781690076787 0.0583824033032945 0.810438680755684 1 15.1 15 1 decreased DN4 thymocyte number 0.0156781690076787 0.0583824033032945 0.810438680755684 1 15.1 15 1 increased oligodendrocyte number 0.0156781690076787 0.0583824033032945 0.810438680755684 1 15.1 15 1 decreased brain cholesterol level 0.0156781690076787 0.0583824033032945 0.810438680755684 1 15.1 15 1 decreased skeletal muscle glycogen level 0.0156781690076787 0.0583824033032945 0.810438680755684 1 15.1 15 1 heart right ventricle outflow tract stenosis 0.0156781690076787 0.0583824033032945 0.810438680755684 1 15.1 15 1 heart block 0.0156781690076787 0.0583824033032945 0.810438680755684 1 15.1 15 1 abnormal conotruncal ridge morphology 0.0156781690076787 0.0583824033032945 0.810438680755684 1 15.1 15 1 thick mitral valve cusps 0.0156781690076787 0.0583824033032945 0.810438680755684 1 15.1 15 1 abnormal outer hair cell kinocilium morphology 0.0156781690076787 0.0583824033032945 0.810438680755684 1 15.1 15 1 small tail bud 0.0156781690076787 0.0583824033032945 0.810438680755684 1 15.1 15 1 decreased CD8-positive, naive alpha-beta T cell number 0.0156781690076787 0.0583824033032945 0.810438680755684 1 15.1 15 1 ductus venosus stenosis 0.0156781690076787 0.0583824033032945 0.810438680755684 1 15.1 15 1 fragmented Meckel's cartilage 0.0156781690076787 0.0583824033032945 0.810438680755684 1 15.1 15 1 echinocytosis 0.0283884335042946 0.0930434385313076 0.810438680755684 1 15.1 15 1 absent organized vascular network 0.0283884335042946 0.0930434385313076 0.810438680755684 1 15.1 15 1 hemoglobinuria 0.0283884335042946 0.0930434385313076 0.810438680755684 1 15.1 15 1 abnormal urethra morphology 0.0283884335042946 0.0930434385313076 0.810438680755684 1 15.1 15 1 absent limbs 0.0283884335042946 0.0930434385313076 0.810438680755684 1 15.1 15 1 absent radius 0.0283884335042946 0.0930434385313076 0.810438680755684 1 15.1 15 1 thin tail 0.0283884335042946 0.0930434385313076 0.810438680755684 1 15.1 15 1 epidermal necrosis 0.0283884335042946 0.0930434385313076 0.810438680755684 1 15.1 15 1 abnormal lacrimal gland physiology 0.0283884335042946 0.0930434385313076 0.810438680755684 1 15.1 15 1 jumpy 0.0283884335042946 0.0930434385313076 0.810438680755684 1 15.1 15 1 abnormal avoidance learning behavior 0.0283884335042946 0.0930434385313076 0.810438680755684 1 15.1 15 1 absent ectoplacental cone 0.0283884335042946 0.0930434385313076 0.810438680755684 1 15.1 15 1 delayed brain development 0.0283884335042946 0.0930434385313076 0.810438680755684 1 15.1 15 1 non-obstructive hydrocephaly 0.0283884335042946 0.0930434385313076 0.810438680755684 1 15.1 15 1 reduced NMDA-mediated synaptic currents 0.0283884335042946 0.0930434385313076 0.810438680755684 1 15.1 15 1 abnormal chemically-elicited antinociception 0.0283884335042946 0.0930434385313076 0.810438680755684 1 15.1 15 1 abnormal cervical lymph node morphology 0.0283884335042946 0.0930434385313076 0.810438680755684 1 15.1 15 1 chromatolysis 0.0283884335042946 0.0930434385313076 0.810438680755684 1 15.1 15 1 increased post-tetanic potentiation 0.0283884335042946 0.0930434385313076 0.810438680755684 1 15.1 15 1 abnormal hippocampal fimbria morphology 0.0283884335042946 0.0930434385313076 0.810438680755684 1 15.1 15 1 loss of hippocampal neurons 0.0283884335042946 0.0930434385313076 0.810438680755684 1 15.1 15 1 bile duct inflammation 0.0283884335042946 0.0930434385313076 0.810438680755684 1 15.1 15 1 esophageal atresia 0.0283884335042946 0.0930434385313076 0.810438680755684 1 15.1 15 1 abnormal intestinal peristalsis 0.0283884335042946 0.0930434385313076 0.810438680755684 1 15.1 15 1 decreased liver function 0.0283884335042946 0.0930434385313076 0.810438680755684 1 15.1 15 1 increased glycerol level 0.0283884335042946 0.0930434385313076 0.810438680755684 1 15.1 15 1 enlarged pancreas 0.0283884335042946 0.0930434385313076 0.810438680755684 1 15.1 15 1 ureter obstruction 0.0283884335042946 0.0930434385313076 0.810438680755684 1 15.1 15 1 matted coat 0.0283884335042946 0.0930434385313076 0.810438680755684 1 15.1 15 1 abnormal heart left atrium morphology 0.0283884335042946 0.0930434385313076 0.810438680755684 1 15.1 15 1 abnormal extensor digitorum longus morphology 0.0283884335042946 0.0930434385313076 0.810438680755684 1 15.1 15 1 short scapula 0.0283884335042946 0.0930434385313076 0.810438680755684 1 15.1 15 1 absent cochlear nerve compound action potential 0.0283884335042946 0.0930434385313076 0.810438680755684 1 15.1 15 1 absent parietal bone 0.0283884335042946 0.0930434385313076 0.810438680755684 1 15.1 15 1 abnormal common crus morphology 0.0283884335042946 0.0930434385313076 0.810438680755684 1 15.1 15 1 decreased prostate gland weight 0.0283884335042946 0.0930434385313076 0.810438680755684 1 15.1 15 1 abnormal blastocoele morphology 0.0283884335042946 0.0930434385313076 0.810438680755684 1 15.1 15 1 abnormal anus morphology 0.0283884335042946 0.0930434385313076 0.810438680755684 1 15.1 15 1 abnormal dermis papillary layer morphology 0.0283884335042946 0.0930434385313076 0.810438680755684 1 15.1 15 1 decreased platelet ADP level 0.0283884335042946 0.0930434385313076 0.810438680755684 1 15.1 15 1 abnormal right lung morphology 0.0283884335042946 0.0930434385313076 0.810438680755684 1 15.1 15 1 abnormal eyelid development 0.0283884335042946 0.0930434385313076 0.810438680755684 1 15.1 15 1 delayed chorioallantoic fusion 0.0283884335042946 0.0930434385313076 0.810438680755684 1 15.1 15 1 abnormal neural crest cell morphology 0.0283884335042946 0.0930434385313076 0.810438680755684 1 15.1 15 1 abnormal aorta tunica adventitia morphology 0.0283884335042946 0.0930434385313076 0.810438680755684 1 15.1 15 1 abnormal olfactory bulb layer morphology 0.0283884335042946 0.0930434385313076 0.810438680755684 1 15.1 15 1 ectopic hippocampus pyramidal cells 0.0283884335042946 0.0930434385313076 0.810438680755684 1 15.1 15 1 visceral vascular congestion 0.0283884335042946 0.0930434385313076 0.810438680755684 1 15.1 15 1 increased erythrocyte clearance 0.0283884335042946 0.0930434385313076 0.810438680755684 1 15.1 15 1 abnormal oval cell physiology 0.0283884335042946 0.0930434385313076 0.810438680755684 1 15.1 15 1 enlarged lymphatic vessel 0.0283884335042946 0.0930434385313076 0.810438680755684 1 15.1 15 1 abnormal heart right ventricle outflow tract morphology 0.0283884335042946 0.0930434385313076 0.810438680755684 1 15.1 15 1 kidney microaneurysm 0.0283884335042946 0.0930434385313076 0.810438680755684 1 15.1 15 1 myocardium hypoplasia 0.0283884335042946 0.0930434385313076 0.810438680755684 1 15.1 15 1 cerebral arteriovenous malformation 0.0283884335042946 0.0930434385313076 0.810438680755684 1 15.1 15 1 abnormal intestinal enteroendocrine cell morphology 0.0283884335042946 0.0930434385313076 0.810438680755684 1 15.1 15 1 abnormal mandibular prominence morphology 0.0283884335042946 0.0930434385313076 0.810438680755684 1 15.1 15 1 abnormal respiratory epithelium morphology 0.0283884335042946 0.0930434385313076 0.810438680755684 1 15.1 15 1 increased macrophage apoptosis 0.0283884335042946 0.0930434385313076 0.810438680755684 1 15.1 15 1 abnormal endocrine pancreas development 0.0283884335042946 0.0930434385313076 0.810438680755684 1 15.1 15 1 increased total retina thickness 0.0283884335042946 0.0930434385313076 0.810438680755684 1 15.1 15 1 thymus cortex atrophy 0.0283884335042946 0.0930434385313076 0.810438680755684 1 15.1 15 1 abnormal vertebral artery origin 0.0283884335042946 0.0930434385313076 0.810438680755684 1 15.1 15 1 abnormal Wolffian duct connection 0.0283884335042946 0.0930434385313076 0.810438680755684 1 15.1 15 1 abnormal platelet alpha-granule morphology 0.0283884335042946 0.0930434385313076 0.810438680755684 1 15.1 15 1 decreased hippocampus volume 0.0283884335042946 0.0930434385313076 0.810438680755684 1 15.1 15 1 decreased tear production 0.0283884335042946 0.0930434385313076 0.810438680755684 1 15.1 15 1 decreased capillary density 0.0283884335042946 0.0930434385313076 0.810438680755684 1 15.1 15 1 abnormal excitatory synapse morphology 0.0283884335042946 0.0930434385313076 0.810438680755684 1 15.1 15 1 absent scala media 0.0514016588924448 0.143907289245871 0.810438680755684 1 15.1 15 1 absent neurocranium 0.0514016588924448 0.143907289245871 0.810438680755684 1 15.1 15 1 small hair follicles 0.0514016588924448 0.143907289245871 0.810438680755684 1 15.1 15 1 abnormal pulmonary trunk morphology 0.0514016588924448 0.143907289245871 0.810438680755684 1 15.1 15 1 kidney vascular congestion 0.0514016588924448 0.143907289245871 0.810438680755684 1 15.1 15 1 absent hindlimb 0.0514016588924448 0.143907289245871 0.810438680755684 1 15.1 15 1 ulcerated paws 0.0514016588924448 0.143907289245871 0.810438680755684 1 15.1 15 1 dissociated hepatocytes 0.0514016588924448 0.143907289245871 0.810438680755684 1 15.1 15 1 abnormal pineal gland morphology 0.0514016588924448 0.143907289245871 0.810438680755684 1 15.1 15 1 ovary hyperplasia 0.0514016588924448 0.143907289245871 0.810438680755684 1 15.1 15 1 absent prostate gland 0.0514016588924448 0.143907289245871 0.810438680755684 1 15.1 15 1 decreased sensitivity to skin irradiation 0.0514016588924448 0.143907289245871 0.810438680755684 1 15.1 15 1 skin hyperplasia 0.0514016588924448 0.143907289245871 0.810438680755684 1 15.1 15 1 kinked vibrissae 0.0514016588924448 0.143907289245871 0.810438680755684 1 15.1 15 1 corneal scarring 0.0514016588924448 0.143907289245871 0.810438680755684 1 15.1 15 1 absent lacrimal glands 0.0514016588924448 0.143907289245871 0.810438680755684 1 15.1 15 1 athetotic walking movements 0.0514016588924448 0.143907289245871 0.810438680755684 1 15.1 15 1 vascular inflammation 0.0514016588924448 0.143907289245871 0.810438680755684 1 15.1 15 1 abnormal nasal mucosa morphology 0.0514016588924448 0.143907289245871 0.810438680755684 1 15.1 15 1 abnormal oropharynx morphology 0.0514016588924448 0.143907289245871 0.810438680755684 1 15.1 15 1 abnormal type I pneumocyte morphology 0.0514016588924448 0.143907289245871 0.810438680755684 1 15.1 15 1 abnormal lung compliance 0.0514016588924448 0.143907289245871 0.810438680755684 1 15.1 15 1 improved righting response 0.0514016588924448 0.143907289245871 0.810438680755684 1 15.1 15 1 opisthotonus 0.0514016588924448 0.143907289245871 0.810438680755684 1 15.1 15 1 increased urine microalbumin level 0.0514016588924448 0.143907289245871 0.810438680755684 1 15.1 15 1 abnormal esophagus development 0.0514016588924448 0.143907289245871 0.810438680755684 1 15.1 15 1 decreased lysosomal enzyme secretion 0.0514016588924448 0.143907289245871 0.810438680755684 1 15.1 15 1 increased lysosomal enzyme secretion 0.0514016588924448 0.143907289245871 0.810438680755684 1 15.1 15 1 enhanced NMDA-mediated synaptic currents 0.0514016588924448 0.143907289245871 0.810438680755684 1 15.1 15 1 gastric polyps 0.0514016588924448 0.143907289245871 0.810438680755684 1 15.1 15 1 epidermal cyst 0.0514016588924448 0.143907289245871 0.810438680755684 1 15.1 15 1 premature endochondral bone ossification 0.0514016588924448 0.143907289245871 0.810438680755684 1 15.1 15 1 sirenomelia 0.0514016588924448 0.143907289245871 0.810438680755684 1 15.1 15 1 increased thyroid adenoma incidence 0.0514016588924448 0.143907289245871 0.810438680755684 1 15.1 15 1 thyroid hypoplasia 0.0514016588924448 0.143907289245871 0.810438680755684 1 15.1 15 1 ischuria 0.0514016588924448 0.143907289245871 0.810438680755684 1 15.1 15 1 abnormal response to vitamins 0.0514016588924448 0.143907289245871 0.810438680755684 1 15.1 15 1 abnormal hypodermis morphology 0.0514016588924448 0.143907289245871 0.810438680755684 1 15.1 15 1 ectopic cartilage 0.0514016588924448 0.143907289245871 0.810438680755684 1 15.1 15 1 increased allantois apoptosis 0.0514016588924448 0.143907289245871 0.810438680755684 1 15.1 15 1 increased heart right ventricle weight 0.0514016588924448 0.143907289245871 0.810438680755684 1 15.1 15 1 abnormal myotome morphology 0.0514016588924448 0.143907289245871 0.810438680755684 1 15.1 15 1 abnormal Descemet membrane 0.0514016588924448 0.143907289245871 0.810438680755684 1 15.1 15 1 absent organ of Corti supporting cells 0.0514016588924448 0.143907289245871 0.810438680755684 1 15.1 15 1 scapular bone foramen 0.0514016588924448 0.143907289245871 0.810438680755684 1 15.1 15 1 absent frontal bone 0.0514016588924448 0.143907289245871 0.810438680755684 1 15.1 15 1 abnormal inner cell mass proliferation 0.0514016588924448 0.143907289245871 0.810438680755684 1 15.1 15 1 erythroblastosis 0.0514016588924448 0.143907289245871 0.810438680755684 1 15.1 15 1 abnormal olfactory cortex morphology 0.0514016588924448 0.143907289245871 0.810438680755684 1 15.1 15 1 decreased unsaturated fatty acid level 0.0514016588924448 0.143907289245871 0.810438680755684 1 15.1 15 1 bronchial epithelial hyperplasia 0.0514016588924448 0.143907289245871 0.810438680755684 1 15.1 15 1 corneal deposits 0.0514016588924448 0.143907289245871 0.810438680755684 1 15.1 15 1 abnormal hemoglobin content 0.0514016588924448 0.143907289245871 0.810438680755684 1 15.1 15 1 increased placenta apoptosis 0.0514016588924448 0.143907289245871 0.810438680755684 1 15.1 15 1 absent optic chiasm 0.0514016588924448 0.143907289245871 0.810438680755684 1 15.1 15 1 enhanced behavioral response to anesthetic 0.0514016588924448 0.143907289245871 0.810438680755684 1 15.1 15 1 abnormal mismatch repair 0.0514016588924448 0.143907289245871 0.810438680755684 1 15.1 15 1 enlarged eye anterior chamber 0.0514016588924448 0.143907289245871 0.810438680755684 1 15.1 15 1 decreased neural crest cell number 0.0514016588924448 0.143907289245871 0.810438680755684 1 15.1 15 1 impaired gastric peristalsis 0.0514016588924448 0.143907289245871 0.810438680755684 1 15.1 15 1 palatal shelf fusion with tongue or mandible 0.0514016588924448 0.143907289245871 0.810438680755684 1 15.1 15 1 abnormal hyoid bone greater horn morphology 0.0514016588924448 0.143907289245871 0.810438680755684 1 15.1 15 1 abnormal olfactory bulb granule cell layer morphology 0.0514016588924448 0.143907289245871 0.810438680755684 1 15.1 15 1 abnormal primitive urogenital sinus morphology 0.0514016588924448 0.143907289245871 0.810438680755684 1 15.1 15 1 decreased DN3 thymocyte number 0.0514016588924448 0.143907289245871 0.810438680755684 1 15.1 15 1 hemolysis 0.0514016588924448 0.143907289245871 0.810438680755684 1 15.1 15 1 increased response to stress-induced hyperthermia 0.0514016588924448 0.143907289245871 0.810438680755684 1 15.1 15 1 increased T follicular helper cell number 0.0514016588924448 0.143907289245871 0.810438680755684 1 15.1 15 1 abnormal lymphatic vessel endothelial cell morphology 0.0514016588924448 0.143907289245871 0.810438680755684 1 15.1 15 1 fused first pharyngeal arch 0.0514016588924448 0.143907289245871 0.810438680755684 1 15.1 15 1 increased thyroid carcinoma incidence 0.0514016588924448 0.143907289245871 0.810438680755684 1 15.1 15 1 decreased QRS amplitude 0.0514016588924448 0.143907289245871 0.810438680755684 1 15.1 15 1 aorta hypoplasia 0.0514016588924448 0.143907289245871 0.810438680755684 1 15.1 15 1 decreased heart left ventricle size 0.0514016588924448 0.143907289245871 0.810438680755684 1 15.1 15 1 enlarged aortic valve 0.0514016588924448 0.143907289245871 0.810438680755684 1 15.1 15 1 abnormal paranode morphology 0.0514016588924448 0.143907289245871 0.810438680755684 1 15.1 15 1 increased Schwann cell number 0.0514016588924448 0.143907289245871 0.810438680755684 1 15.1 15 1 pale lung 0.0514016588924448 0.143907289245871 0.810438680755684 1 15.1 15 1 pulmonary alveolar edema 0.0514016588924448 0.143907289245871 0.810438680755684 1 15.1 15 1 alveolitis 0.0514016588924448 0.143907289245871 0.810438680755684 1 15.1 15 1 fused right lung lobes 0.0514016588924448 0.143907289245871 0.810438680755684 1 15.1 15 1 abnormal lung alveolus development 0.0514016588924448 0.143907289245871 0.810438680755684 1 15.1 15 1 abnormal circadian regulation of heart rate 0.0514016588924448 0.143907289245871 0.810438680755684 1 15.1 15 1 abnormal circadian regulation of systemic arterial blood pressure 0.0514016588924448 0.143907289245871 0.810438680755684 1 15.1 15 1 impaired branching involved in terminal bronchiole morphogenesis 0.0514016588924448 0.143907289245871 0.810438680755684 1 15.1 15 1 blind ureter 0.0514016588924448 0.143907289245871 0.810438680755684 1 15.1 15 1 cerebral edema 0.0514016588924448 0.143907289245871 0.810438680755684 1 15.1 15 1 midface hypoplasia 0.0514016588924448 0.143907289245871 0.810438680755684 1 15.1 15 1 abnormal mammary gland bud morphology 0.0514016588924448 0.143907289245871 0.810438680755684 1 15.1 15 1 abnormal mitophagy 0.0514016588924448 0.143907289245871 0.810438680755684 1 15.1 15 1 decreased small intestinal villus height 0.0514016588924448 0.143907289245871 0.810438680755684 1 15.1 15 1 decreased fibroblast chemotaxis 0.0514016588924448 0.143907289245871 0.810438680755684 1 15.1 15 1 decreased platelet alpha-granule number 0.0514016588924448 0.143907289245871 0.810438680755684 1 15.1 15 1 scoliosis 5.56887117101151e-09 1.14484025106538e-07 0.810438680755684 1 15.1 15 1 abnormal auditory brainstem response waveform shape 5.56887117101151e-09 1.14484025106538e-07 0.810438680755684 1 15.1 15 1 enhanced paired-pulse facilitation 1.82796762788401e-08 3.51125055935248e-07 0.810438680755684 1 15.1 15 1 abnormal stationary movement 1.25988919535943e-05 0.000131956815724487 0.810438680755684 1 15.1 15 1 abnormal nasal septum morphology 1.25988919535943e-05 0.000131956815724487 0.810438680755684 1 15.1 15 1 increased liver adenoma incidence 1.25988919535943e-05 0.000131956815724487 0.810438680755684 1 15.1 15 1 abnormal mitral valve morphology 2.28193392403081e-05 0.000223476796693962 0.810438680755684 1 15.1 15 1 absent ureter 2.28193392403081e-05 0.000223476796693962 0.810438680755684 1 15.1 15 1 increased effector memory CD4-positive, alpha-beta T cell number 2.28193392403081e-05 0.000223476796693962 0.810438680755684 1 15.1 15 1 abnormal hypoglossal nerve topology 2.28193392403081e-05 0.000223476796693962 0.810438680755684 1 15.1 15 1 failure of tooth eruption 7.48537084585099e-05 0.00063549010167421 0.810438680755684 1 15.1 15 1 impaired muscle relaxation 7.48537084585099e-05 0.00063549010167421 0.810438680755684 1 15.1 15 1 increased cochlear outer hair cell number 7.48537084585099e-05 0.00063549010167421 0.810438680755684 1 15.1 15 1 impaired somite development 7.48537084585099e-05 0.00063549010167421 0.810438680755684 1 15.1 15 1 abnormal glial cell morphology 0.000135566650649982 0.00106884958317537 0.810438680755684 1 15.1 15 1 abnormal rostral migratory stream morphology 0.000135566650649982 0.00106884958317537 0.810438680755684 1 15.1 15 1 abnormal cerebral aqueduct morphology 0.000135566650649982 0.00106884958317537 0.810438680755684 1 15.1 15 1 liver vascular congestion 0.000135566650649982 0.00106884958317537 0.810438680755684 1 15.1 15 1 heterochrony 0.000135566650649982 0.00106884958317537 0.810438680755684 1 15.1 15 1 excessive scratching 0.000444632080556301 0.00297717981260781 0.810438680755684 1 15.1 15 1 abnormal grip strength 0.000444632080556301 0.00297717981260781 0.810438680755684 1 15.1 15 1 increased synaptic depression 0.000444632080556301 0.00297717981260781 0.810438680755684 1 15.1 15 1 anal atresia 0.000444632080556301 0.00297717981260781 0.810438680755684 1 15.1 15 1 axonal dystrophy 0.000444632080556301 0.00297717981260781 0.810438680755684 1 15.1 15 1 increased cochlear inner hair cell number 0.000444632080556301 0.00297717981260781 0.810438680755684 1 15.1 15 1 absent hypoglossal nerve 0.000444632080556301 0.00297717981260781 0.810438680755684 1 15.1 15 1 heart hyperplasia 0.00478158659154366 0.0225268875880016 0.810438680755684 1 15.1 15 1 abnormal urinary bladder urothelium morphology 0.00478158659154366 0.0225268875880016 0.810438680755684 1 15.1 15 1 abnormal geniculate ganglion morphology 0.00478158659154366 0.0225268875880016 0.810438680755684 1 15.1 15 1 abnormal posterior semicircular canal morphology 0.00478158659154366 0.0225268875880016 0.810438680755684 1 15.1 15 1 abnormal NMDA-mediated synaptic currents 0.00478158659154366 0.0225268875880016 0.810438680755684 1 15.1 15 1 pancreas cysts 0.00478158659154366 0.0225268875880016 0.810438680755684 1 15.1 15 1 decreased fear-related response 0.00478158659154366 0.0225268875880016 0.810438680755684 1 15.1 15 1 abnormal thymus physiology 0.00478158659154366 0.0225268875880016 0.810438680755684 1 15.1 15 1 decreased cellular sensitivity to ionizing radiation 0.00478158659154366 0.0225268875880016 0.810438680755684 1 15.1 15 1 abnormal proprioceptive neuron morphology 0.00478158659154366 0.0225268875880016 0.810438680755684 1 15.1 15 1 small scapula 0.00478158659154366 0.0225268875880016 0.810438680755684 1 15.1 15 1 abnormal stria vascularis vasculature morphology 0.00478158659154366 0.0225268875880016 0.810438680755684 1 15.1 15 1 increased neuronal precursor cell number 0.00478158659154366 0.0225268875880016 0.810438680755684 1 15.1 15 1 liver hyperplasia 0.00478158659154366 0.0225268875880016 0.810438680755684 1 15.1 15 1 abnormal inguinal fat pad morphology 0.00478158659154366 0.0225268875880016 0.810438680755684 1 15.1 15 1 abnormal leukopoiesis 0.00478158659154366 0.0225268875880016 0.810438680755684 1 15.1 15 1 enhanced conditioned place preference behavior 0.00478158659154366 0.0225268875880016 0.810438680755684 1 15.1 15 1 abnormal optic chiasm morphology 0.00478158659154366 0.0225268875880016 0.810438680755684 1 15.1 15 1 abnormal liver vasculature morphology 0.00478158659154366 0.0225268875880016 0.810438680755684 1 15.1 15 1 abnormal hippocampus granule cell morphology 0.00478158659154366 0.0225268875880016 0.810438680755684 1 15.1 15 1 shortened ST segment 0.00478158659154366 0.0225268875880016 0.810438680755684 1 15.1 15 1 decreased effector memory CD4-positive, alpha-beta T cell number 0.00478158659154366 0.0225268875880016 0.810438680755684 1 15.1 15 1 abnormal ureteric bud invasion 0.00478158659154366 0.0225268875880016 0.810438680755684 1 15.1 15 1 reduced AMPA-mediated synaptic currents 0.00478158659154366 0.0225268875880016 0.810438680755684 1 15.1 15 1 abnormal ductus venosus valve topology 0.00478158659154366 0.0225268875880016 0.810438680755684 1 15.1 15 1 abnormal infrahyoid muscle connection 0.00478158659154366 0.0225268875880016 0.810438680755684 1 15.1 15 1 symmetric azygos veins 0.00478158659154366 0.0225268875880016 0.810438680755684 1 15.1 15 1 increased cardiac muscle glycogen level 0.00478158659154366 0.0225268875880016 0.810438680755684 1 15.1 15 1 cerebellum atrophy 0.00478158659154366 0.0225268875880016 0.810438680755684 1 15.1 15 1 decreased platelet dense granule number 0.00478158659154366 0.0225268875880016 0.810438680755684 1 15.1 15 1 abnormal exoccipital bone morphology 0.00865842449753309 0.0357474372408524 0.810438680755684 1 15.1 15 1 abnormal cecum morphology 0.00865842449753309 0.0357474372408524 0.810438680755684 1 15.1 15 1 increased sensitivity to skin irradiation 0.00865842449753309 0.0357474372408524 0.810438680755684 1 15.1 15 1 dry eyes 0.00865842449753309 0.0357474372408524 0.810438680755684 1 15.1 15 1 absent eyelids 0.00865842449753309 0.0357474372408524 0.810438680755684 1 15.1 15 1 abnormal hepatobiliary system morphology 0.00865842449753309 0.0357474372408524 0.810438680755684 1 15.1 15 1 abnormal pulmonary circulation 0.00865842449753309 0.0357474372408524 0.810438680755684 1 15.1 15 1 decreased aerobic running capacity 0.00865842449753309 0.0357474372408524 0.810438680755684 1 15.1 15 1 early eyelid opening 0.00865842449753309 0.0357474372408524 0.810438680755684 1 15.1 15 1 abnormal cellular cholesterol metabolism 0.00865842449753309 0.0357474372408524 0.810438680755684 1 15.1 15 1 abnormal neuron apoptosis 0.00865842449753309 0.0357474372408524 0.810438680755684 1 15.1 15 1 colon polyps 0.00865842449753309 0.0357474372408524 0.810438680755684 1 15.1 15 1 liver failure 0.00865842449753309 0.0357474372408524 0.810438680755684 1 15.1 15 1 liver cysts 0.00865842449753309 0.0357474372408524 0.810438680755684 1 15.1 15 1 abnormal eyelid aperture 0.00865842449753309 0.0357474372408524 0.810438680755684 1 15.1 15 1 elevated level of mitotic sister chromatid exchange 0.00865842449753309 0.0357474372408524 0.810438680755684 1 15.1 15 1 increased left ventricle systolic pressure 0.00865842449753309 0.0357474372408524 0.810438680755684 1 15.1 15 1 tau protein deposits 0.00865842449753309 0.0357474372408524 0.810438680755684 1 15.1 15 1 abnormal lateral ganglionic eminence morphology 0.00865842449753309 0.0357474372408524 0.810438680755684 1 15.1 15 1 absent interparietal bone 0.00865842449753309 0.0357474372408524 0.810438680755684 1 15.1 15 1 accumulation of giant lysosomes in kidney/renal tubule cells 0.00865842449753309 0.0357474372408524 0.810438680755684 1 15.1 15 1 abnormal somite size 0.00865842449753309 0.0357474372408524 0.810438680755684 1 15.1 15 1 abnormal olfactory tract morphology 0.00865842449753309 0.0357474372408524 0.810438680755684 1 15.1 15 1 abnormal ilium morphology 0.00865842449753309 0.0357474372408524 0.810438680755684 1 15.1 15 1 craniofacial phenotype 0.00865842449753309 0.0357474372408524 0.810438680755684 1 15.1 15 1 abnormal meiotic spindle morphology 0.00865842449753309 0.0357474372408524 0.810438680755684 1 15.1 15 1 abnormal mitotic spindle assembly checkpoint 0.00865842449753309 0.0357474372408524 0.810438680755684 1 15.1 15 1 abnormal olfactory bulb glomerular layer morphology 0.00865842449753309 0.0357474372408524 0.810438680755684 1 15.1 15 1 abnormal olfactory bulb mitral cell layer morphology 0.00865842449753309 0.0357474372408524 0.810438680755684 1 15.1 15 1 abnormal cerebellum deep nucleus morphology 0.00865842449753309 0.0357474372408524 0.810438680755684 1 15.1 15 1 increased caudal vertebrae number 0.00865842449753309 0.0357474372408524 0.810438680755684 1 15.1 15 1 abnormal circulating serum amyloid protein level 0.00865842449753309 0.0357474372408524 0.810438680755684 1 15.1 15 1 pleural effusion 0.00865842449753309 0.0357474372408524 0.810438680755684 1 15.1 15 1 ostium secundum atrial septal defect 0.00865842449753309 0.0357474372408524 0.810438680755684 1 15.1 15 1 sinoatrial block 0.00865842449753309 0.0357474372408524 0.810438680755684 1 15.1 15 1 abnormal visual evoked potential 0.00865842449753309 0.0357474372408524 0.810438680755684 1 15.1 15 1 lung situs inversus 0.00865842449753309 0.0357474372408524 0.810438680755684 1 15.1 15 1 abnormal anterior commissure pars posterior morphology 0.00865842449753309 0.0357474372408524 0.810438680755684 1 15.1 15 1 abnormal maxillary prominence morphology 0.00865842449753309 0.0357474372408524 0.810438680755684 1 15.1 15 1 abnormal foramen magnum morphology 0.00865842449753309 0.0357474372408524 0.810438680755684 1 15.1 15 1 absent ureteric bud 0.00865842449753309 0.0357474372408524 0.810438680755684 1 15.1 15 1 increased aorta wall thickness 0.00865842449753309 0.0357474372408524 0.810438680755684 1 15.1 15 1 impaired neuron differentiation 0.00865842449753309 0.0357474372408524 0.810438680755684 1 15.1 15 1 increased cardiac stroke volume 0.00865842449753309 0.0357474372408524 0.810438680755684 1 15.1 15 1 absent hypoglossal canal 0.00865842449753309 0.0357474372408524 0.810438680755684 1 15.1 15 1 retropleural edema 0.00865842449753309 0.0357474372408524 0.810438680755684 1 15.1 15 1 abnormal umbilical vein topology 0.00865842449753309 0.0357474372408524 0.810438680755684 1 15.1 15 1 embryo cyst 0.00865842449753309 0.0357474372408524 0.810438680755684 1 15.1 15 1 increased brain apoptosis 0.00865842449753309 0.0357474372408524 0.810438680755684 1 15.1 15 1 impaired synaptic plasticity 1.69638425332407e-09 3.80158182895822e-08 0.810438680755683 1 15.1 15 1 hyperlipidemia 4.13298080028378e-05 0.000369812580600932 0.810438680755683 1 15.1 15 1 abnormal dorsal-ventral axis patterning 4.13298080028378e-05 0.000369812580600932 0.810438680755683 1 15.1 15 1 abnormal lung development 7.89897407652438e-21 8.36114809164017e-19 0.800904108040911 0.988235294117647 15.1 15 1 increased neuron apoptosis 8.15495022725466e-20 8.11417547611839e-18 0.800433264943885 0.987654320987654 15.1 15 1 abnormal head morphology 2.92687210509866e-13 1.20340402668313e-11 0.795703432014671 0.981818181818182 15.1 15 1 muscular atrophy 1.63245014058918e-10 4.27444181549008e-09 0.792019619829418 0.977272727272727 15.1 15 1 abnormal excitatory postsynaptic currents 1.49285309289062e-17 1.03152001904595e-15 0.789658201761948 0.974358974358974 15.1 15 1 increased embryonic tissue cell apoptosis 1.49285309289062e-17 1.03152001904595e-15 0.789658201761948 0.974358974358974 15.1 15 1 reduced long term depression 1.56200866836062e-08 3.03554418948987e-07 0.787926495179137 0.972222222222222 15.1 15 1 abnormal pharyngeal arch morphology 1.56200866836062e-08 3.03554418948987e-07 0.787926495179137 0.972222222222222 15.1 15 1 enlarged liver sinusoidal spaces 4.85225752831716e-08 8.81021211802111e-07 0.786602248968752 0.970588235294118 15.1 15 1 abnormal locomotor coordination 8.54167433324477e-08 1.46533895889285e-06 0.785879932853996 0.96969696969697 15.1 15 1 abnormal QRS complex 8.54167433324477e-08 1.46533895889285e-06 0.785879932853996 0.96969696969697 15.1 15 1 pancreatic islet hyperplasia 1.50231515277248e-07 2.41877601457706e-06 0.785112471982068 0.96875 15.1 15 1 pericardial effusion 1.2946934155987e-13 5.70008826779072e-12 0.7842954975055 0.967741935483871 15.1 15 1 abnormal synaptic transmission 4.63405279951615e-07 6.66312505132742e-06 0.783424058063827 0.966666666666667 15.1 15 1 abnormal middle ear morphology 8.12626260641733e-07 1.10459443898705e-05 0.782492519350315 0.96551724137931 15.1 15 1 abnormal spinal nerve morphology 8.12626260641733e-07 1.10459443898705e-05 0.782492519350315 0.96551724137931 15.1 15 1 absent long term depression 8.12626260641733e-07 1.10459443898705e-05 0.782492519350315 0.96551724137931 15.1 15 1 decreased brain weight 2.14698543293829e-12 7.68435433731511e-11 0.782002235816888 0.964912280701754 15.1 15 1 myoclonus 1.42342622144989e-06 1.85380770987256e-05 0.781494442157266 0.964285714285714 15.1 15 1 increased triglyceride level 1.42342622144989e-06 1.85380770987256e-05 0.781494442157266 0.964285714285714 15.1 15 1 subcutaneous edema 1.42342622144989e-06 1.85380770987256e-05 0.781494442157266 0.964285714285714 15.1 15 1 abnormal fetal cardiomyocyte proliferation 2.49034897104515e-06 3.11293621380644e-05 0.780422433320288 0.962962962962963 15.1 15 1 abnormal brain wave pattern 3.5051482842597e-11 1.07642671075259e-09 0.77926796226508 0.961538461538462 15.1 15 1 abnormal erythrocyte osmotic lysis 4.35140910060212e-06 5.10572176308857e-05 0.77926796226508 0.961538461538462 15.1 15 1 abnormal nerve conduction 4.35140910060212e-06 5.10572176308857e-05 0.77926796226508 0.961538461538462 15.1 15 1 abnormal dendritic spine morphology 6.11448615658337e-11 1.76857957145362e-09 0.778656771706441 0.96078431372549 15.1 15 1 abnormal hindlimb morphology 1.06580912990123e-10 2.96223487221151e-09 0.778021133525456 0.96 15.1 15 1 short stride length 1.06580912990123e-10 2.96223487221151e-09 0.778021133525456 0.96 15.1 15 1 increased liver glycogen level 7.59282319369791e-06 8.41298338277218e-05 0.778021133525456 0.96 15.1 15 1 overriding aortic valve 3.23045648596755e-10 8.19975562126966e-09 0.776670402390863 0.958333333333333 15.1 15 1 abnormal cell death 9.75769462847637e-10 2.34514641433188e-08 0.775202216375002 0.956521739130435 15.1 15 1 abnormal forelimb morphology 9.75769462847637e-10 2.34514641433188e-08 0.775202216375002 0.956521739130435 15.1 15 1 abnormal sacral vertebrae morphology 2.30130022297136e-05 0.000224050266326468 0.775202216375002 0.956521739130435 15.1 15 1 abnormal Wolffian duct morphology 2.30130022297136e-05 0.000224050266326468 0.775202216375002 0.956521739130435 15.1 15 1 abnormal basicranium morphology 2.30130022297136e-05 0.000224050266326468 0.775202216375002 0.956521739130435 15.1 15 1 abnormal myocardial trabeculae morphology 1.6935063779618e-09 3.80158182895822e-08 0.774419183833209 0.955555555555556 15.1 15 1 intracerebral hemorrhage 3.99632938378225e-05 0.000362144602628719 0.773600558903153 0.954545454545455 15.1 15 1 increased skin papilloma incidence 3.99632938378225e-05 0.000362144602628719 0.773600558903153 0.954545454545455 15.1 15 1 abnormal limb posture 3.99632938378225e-05 0.000362144602628719 0.773600558903153 0.954545454545455 15.1 15 1 abnormal occipital bone morphology 3.99632938378225e-05 0.000362144602628719 0.773600558903153 0.954545454545455 15.1 15 1 abnormal cerebral cortex pyramidal cell morphology 3.99632938378225e-05 0.000362144602628719 0.773600558903153 0.954545454545455 15.1 15 1 abnormal scapula morphology 6.92681547593961e-05 0.000595179740808282 0.771846362624461 0.952380952380952 15.1 15 1 abnormal erythrocyte physiology 6.92681547593961e-05 0.000595179740808282 0.771846362624461 0.952380952380952 15.1 15 1 increased muscle cell glucose uptake 6.92681547593961e-05 0.000595179740808282 0.771846362624461 0.952380952380952 15.1 15 1 abnormal pericardium morphology 0.000119816372883792 0.000982020519105216 0.7699167467179 0.95 15.1 15 1 abnormal vascular regression 0.000119816372883792 0.000982020519105216 0.7699167467179 0.95 15.1 15 1 anencephaly 0.000119816372883792 0.000982020519105216 0.7699167467179 0.95 15.1 15 1 abnormal dopamine level 0.000119816372883792 0.000982020519105216 0.7699167467179 0.95 15.1 15 1 decreased myocardial infarction size 0.000119816372883792 0.000982020519105216 0.7699167467179 0.95 15.1 15 1 spleen atrophy 0.000119816372883792 0.000982020519105216 0.7699167467179 0.95 15.1 15 1 abnormal optic stalk morphology 0.000119816372883792 0.000982020519105216 0.7699167467179 0.95 15.1 15 1 absent ductus venosus valve 0.000119816372883792 0.000982020519105216 0.7699167467179 0.95 15.1 15 1 abnormal nervous system morphology 2.81968495496243e-15 1.52477528814545e-13 0.769403810844004 0.949367088607595 15.1 15 1 increased hepatocellular carcinoma incidence 3.27607258360089e-11 1.0186538189634e-09 0.76778401334749 0.947368421052632 15.1 15 1 kyphoscoliosis 0.000206787390401156 0.00155638013199055 0.76778401334749 0.947368421052632 15.1 15 1 stereotypic behavior 0.000206787390401156 0.00155638013199055 0.76778401334749 0.947368421052632 15.1 15 1 unresponsive to tactile stimuli 0.000206787390401156 0.00155638013199055 0.76778401334749 0.947368421052632 15.1 15 1 abnormal long term depression 0.000206787390401156 0.00155638013199055 0.76778401334749 0.947368421052632 15.1 15 1 delayed sexual maturation 0.000206787390401156 0.00155638013199055 0.76778401334749 0.947368421052632 15.1 15 1 abnormal metatarsal bone morphology 0.000206787390401156 0.00155638013199055 0.76778401334749 0.947368421052632 15.1 15 1 abnormal blastocyst morphology 0.000206787390401156 0.00155638013199055 0.76778401334749 0.947368421052632 15.1 15 1 decreased width of hypertrophic chondrocyte zone 1.34055398133127e-07 2.20836293282221e-06 0.76663118449862 0.945945945945946 15.1 15 1 abnormal digit morphology 1.25303435104466e-13 5.56593383611354e-12 0.76541430960259 0.944444444444444 15.1 15 1 heart right ventricle hypertrophy 2.30201771585308e-07 3.51304850808868e-06 0.76541430960259 0.944444444444444 15.1 15 1 abnormal lysosome morphology 2.30201771585308e-07 3.51304850808868e-06 0.76541430960259 0.944444444444444 15.1 15 1 abnormal bile duct morphology 0.000356007776965843 0.00248406548443909 0.76541430960259 0.944444444444444 15.1 15 1 abnormal metacarpal bone morphology 0.000356007776965843 0.00248406548443909 0.76541430960259 0.944444444444444 15.1 15 1 decreased cellular sensitivity to gamma-irradiation 0.000356007776965843 0.00248406548443909 0.76541430960259 0.944444444444444 15.1 15 1 abnormal body wall morphology 0.000356007776965843 0.00248406548443909 0.76541430960259 0.944444444444444 15.1 15 1 absent inner cell mass 0.000356007776965843 0.00248406548443909 0.76541430960259 0.944444444444444 15.1 15 1 small thoracic cage 0.000356007776965843 0.00248406548443909 0.76541430960259 0.944444444444444 15.1 15 1 abnormal liver development 3.94713759349442e-07 5.74181565135518e-06 0.764127898998216 0.942857142857143 15.1 15 1 abnormal placenta vasculature 4.87336714045367e-10 1.19433505043138e-08 0.763682603019779 0.942307692307692 15.1 15 1 abnormal inhibitory postsynaptic currents 1.076707862127e-12 4.08902413288689e-11 0.76276581718182 0.941176470588235 15.1 15 1 abnormal nervous system development 6.75723432120866e-07 9.49639569152912e-06 0.76276581718182 0.941176470588235 15.1 15 1 abnormal bone marrow cavity morphology 0.000611236115749267 0.003954355885374 0.76276581718182 0.941176470588235 15.1 15 1 abnormal interatrial septum morphology 0.000611236115749267 0.003954355885374 0.76276581718182 0.941176470588235 15.1 15 1 abnormal vagus nerve morphology 0.000611236115749267 0.003954355885374 0.76276581718182 0.941176470588235 15.1 15 1 abnormal glutamate-mediated receptor currents 0.000611236115749267 0.003954355885374 0.76276581718182 0.941176470588235 15.1 15 1 absence seizures 0.000611236115749267 0.003954355885374 0.76276581718182 0.941176470588235 15.1 15 1 abnormal involuntary movement 0.000611236115749267 0.003954355885374 0.76276581718182 0.941176470588235 15.1 15 1 abnormal embryonic-extraembryonic boundary morphology 0.000611236115749267 0.003954355885374 0.76276581718182 0.941176470588235 15.1 15 1 increased regulatory T cell number 0.000611236115749267 0.003954355885374 0.76276581718182 0.941176470588235 15.1 15 1 increased brain size 0.000611236115749267 0.003954355885374 0.76276581718182 0.941176470588235 15.1 15 1 abnormal survival 0.000611236115749267 0.003954355885374 0.76276581718182 0.941176470588235 15.1 15 1 dilated heart atrium 1.15486048042168e-06 1.54032999734527e-05 0.761321184952309 0.939393939393939 15.1 15 1 single kidney 1.15486048042168e-06 1.54032999734527e-05 0.761321184952309 0.939393939393939 15.1 15 1 abnormal craniofacial development 2.43006074637453e-09 5.30243518123389e-08 0.76081998601554 0.938775510204082 15.1 15 1 reduced long term potentiation 1.08841406382805e-19 1.02167169198953e-17 0.759786263208453 0.9375 15.1 15 1 bradykinesia 1.97024888146685e-06 2.51979130727444e-05 0.759786263208453 0.9375 15.1 15 1 increased fibroblast apoptosis 1.97024888146685e-06 2.51979130727444e-05 0.759786263208453 0.9375 15.1 15 1 abnormal tympanic ring morphology 0.00104626078352206 0.00622625286844769 0.759786263208453 0.9375 15.1 15 1 absent mandible 0.00104626078352206 0.00622625286844769 0.759786263208453 0.9375 15.1 15 1 vasculature congestion 0.00104626078352206 0.00622625286844769 0.759786263208453 0.9375 15.1 15 1 intraventricular hemorrhage 0.00104626078352206 0.00622625286844769 0.759786263208453 0.9375 15.1 15 1 increased intestinal adenocarcinoma incidence 0.00104626078352206 0.00622625286844769 0.759786263208453 0.9375 15.1 15 1 bowed tibia 0.00104626078352206 0.00622625286844769 0.759786263208453 0.9375 15.1 15 1 bowed radius 0.00104626078352206 0.00622625286844769 0.759786263208453 0.9375 15.1 15 1 decreased liver cholesterol level 0.00104626078352206 0.00622625286844769 0.759786263208453 0.9375 15.1 15 1 decreased fibroblast apoptosis 0.00104626078352206 0.00622625286844769 0.759786263208453 0.9375 15.1 15 1 pulmonary hypoplasia 7.04885735558751e-09 1.4313496058795e-07 0.75870855219681 0.936170212765957 15.1 15 1 increased cellular sensitivity to gamma-irradiation 7.04885735558751e-09 1.4313496058795e-07 0.75870855219681 0.936170212765957 15.1 15 1 abnormal cranial ganglia morphology 3.3550341296206e-06 4.06114228585462e-05 0.758152314255317 0.935483870967742 15.1 15 1 preaxial polydactyly 3.3550341296206e-06 4.06114228585462e-05 0.758152314255317 0.935483870967742 15.1 15 1 failure to gastrulate 1.19810688279314e-08 2.3747337617115e-07 0.757583984184661 0.934782608695652 15.1 15 1 abnormal long bone morphology 4.48166159411416e-11 1.32715871611416e-09 0.757295160706131 0.934426229508197 15.1 15 1 muscular ventricular septal defect 7.60277843653357e-11 2.16136129838597e-09 0.756409435371971 0.933333333333333 15.1 15 1 abnormal heart tube morphology 5.70171999030336e-06 6.5662168869813e-05 0.756409435371971 0.933333333333333 15.1 15 1 abnormal response to new environment 5.70171999030336e-06 6.5662168869813e-05 0.756409435371971 0.933333333333333 15.1 15 1 abnormal optic cup morphology 5.70171999030336e-06 6.5662168869813e-05 0.756409435371971 0.933333333333333 15.1 15 1 macrocytosis 0.00178482574868242 0.0098551699219701 0.756409435371971 0.933333333333333 15.1 15 1 interdigital webbing 0.00178482574868242 0.0098551699219701 0.756409435371971 0.933333333333333 15.1 15 1 abnormal enteric neuron morphology 0.00178482574868242 0.0098551699219701 0.756409435371971 0.933333333333333 15.1 15 1 abnormal prostate gland morphology 0.00178482574868242 0.0098551699219701 0.756409435371971 0.933333333333333 15.1 15 1 abnormal pup retrieval 0.00178482574868242 0.0098551699219701 0.756409435371971 0.933333333333333 15.1 15 1 abnormal seizure response to electrical stimulation 0.00178482574868242 0.0098551699219701 0.756409435371971 0.933333333333333 15.1 15 1 abnormal apical ectodermal ridge morphology 0.00178482574868242 0.0098551699219701 0.756409435371971 0.933333333333333 15.1 15 1 delayed intramembranous bone ossification 0.00178482574868242 0.0098551699219701 0.756409435371971 0.933333333333333 15.1 15 1 abnormal olfactory nerve morphology 0.00178482574868242 0.0098551699219701 0.756409435371971 0.933333333333333 15.1 15 1 abnormal zygomatic bone morphology 0.00178482574868242 0.0098551699219701 0.756409435371971 0.933333333333333 15.1 15 1 immune system phenotype 0.00178482574868242 0.0098551699219701 0.756409435371971 0.933333333333333 15.1 15 1 abnormal neurotransmitter secretion 0.00178482574868242 0.0098551699219701 0.756409435371971 0.933333333333333 15.1 15 1 abnormal secondary palate development 0.00178482574868242 0.0098551699219701 0.756409435371971 0.933333333333333 15.1 15 1 omphalocele 3.44647615532795e-08 6.44594694464532e-07 0.755181497976887 0.931818181818182 15.1 15 1 short limbs 5.50691028537249e-15 2.79559986425797e-13 0.754546357944947 0.931034482758621 15.1 15 1 cochlear ganglion degeneration 2.180417863754e-10 5.62050718765605e-09 0.754546357944947 0.931034482758621 15.1 15 1 blood in lymph vessels 9.66922569236007e-06 0.000104802609628521 0.754546357944947 0.931034482758621 15.1 15 1 hydrops fetalis 1.41410113423923e-12 5.13514827944538e-11 0.754158216814317 0.930555555555556 15.1 15 1 abnormal nervous system physiology 2.44864876962935e-19 2.25593104239e-17 0.754060337746593 0.930434782608696 15.1 15 1 abnormal vasculogenesis 5.83206851459051e-08 1.03623360214599e-06 0.753896447214589 0.930232558139535 15.1 15 1 abnormal axon guidance 5.83206851459051e-08 1.03623360214599e-06 0.753896447214589 0.930232558139535 15.1 15 1 delayed endochondral bone ossification 5.83206851459051e-08 1.03623360214599e-06 0.753896447214589 0.930232558139535 15.1 15 1 abnormal cell morphology 4.1380413629027e-19 3.54944065180016e-17 0.753565790878092 0.929824561403509 15.1 15 1 incomplete embryo turning 3.68586986327716e-10 9.26121341909286e-09 0.753565790878092 0.929824561403509 15.1 15 1 abnormal facial morphology 3.68586986327716e-10 9.26121341909286e-09 0.753565790878092 0.929824561403509 15.1 15 1 limb grasping 1.6372094250424e-29 3.13273726522536e-27 0.752550203558849 0.928571428571429 15.1 15 1 abnormal nervous system electrophysiology 2.6536198114765e-14 1.2573103392472e-12 0.752550203558849 0.928571428571429 15.1 15 1 rib bifurcation 1.63603447157835e-05 0.000166788350329965 0.752550203558849 0.928571428571429 15.1 15 1 small superior cervical ganglion 1.63603447157835e-05 0.000166788350329965 0.752550203558849 0.928571428571429 15.1 15 1 absent corpus callosum 1.63603447157835e-05 0.000166788350329965 0.752550203558849 0.928571428571429 15.1 15 1 increased bone resorption 1.63603447157835e-05 0.000166788350329965 0.752550203558849 0.928571428571429 15.1 15 1 hypoxia 1.63603447157835e-05 0.000166788350329965 0.752550203558849 0.928571428571429 15.1 15 1 midline facial cleft 0.00303312478437702 0.015335158335646 0.752550203558849 0.928571428571429 15.1 15 1 abnormal blood flow velocity 0.00303312478437702 0.015335158335646 0.752550203558849 0.928571428571429 15.1 15 1 megacephaly 0.00303312478437702 0.015335158335646 0.752550203558849 0.928571428571429 15.1 15 1 abnormal kidney blood vessel morphology 0.00303312478437702 0.015335158335646 0.752550203558849 0.928571428571429 15.1 15 1 increased aggression towards males 0.00303312478437702 0.015335158335646 0.752550203558849 0.928571428571429 15.1 15 1 increased hemangioma incidence 0.00303312478437702 0.015335158335646 0.752550203558849 0.928571428571429 15.1 15 1 amyloid beta deposits 0.00303312478437702 0.015335158335646 0.752550203558849 0.928571428571429 15.1 15 1 failure of zygotic cell division 0.00303312478437702 0.015335158335646 0.752550203558849 0.928571428571429 15.1 15 1 abnormal voluntary movement 0.00303312478437702 0.015335158335646 0.752550203558849 0.928571428571429 15.1 15 1 decreased CNS synapse formation 0.00303312478437702 0.015335158335646 0.752550203558849 0.928571428571429 15.1 15 1 abnormal viscerocranium morphology 0.00303312478437702 0.015335158335646 0.752550203558849 0.928571428571429 15.1 15 1 pulmonary alveolar hemorrhage 0.00303312478437702 0.015335158335646 0.752550203558849 0.928571428571429 15.1 15 1 abnormal contextual conditioning behavior 1.04925786213497e-09 2.47396107304334e-08 0.751497685791634 0.927272727272727 15.1 15 1 abnormal learning/memory/conditioning 1.04925786213497e-09 2.47396107304334e-08 0.751497685791634 0.927272727272727 15.1 15 1 abnormal cell differentiation 1.66179988223787e-07 2.6245887028995e-06 0.751138289480878 0.926829268292683 15.1 15 1 ventricular septal defect 4.3063208934141e-22 4.76087698771892e-20 0.750847601288354 0.926470588235294 15.1 15 1 pericardial edema 1.14501182460734e-11 3.72315936432779e-10 0.750847601288354 0.926470588235294 15.1 15 1 abnormal spatial learning 3.30832603608828e-26 5.143413134231e-24 0.750774483399437 0.926380368098159 15.1 15 1 abnormal axon morphology 9.50131969272603e-18 6.85058919874087e-16 0.750406185884892 0.925925925925926 15.1 15 1 abnormal chondrocyte morphology 1.76678879346678e-09 3.92400636048984e-08 0.750406185884892 0.925925925925926 15.1 15 1 abnormal maxilla morphology 1.76678879346678e-09 3.92400636048984e-08 0.750406185884892 0.925925925925926 15.1 15 1 abnormal eye muscle morphology 2.76146607200642e-05 0.000257754103343939 0.750406185884892 0.925925925925926 15.1 15 1 abnormal skin appearance 2.76146607200642e-05 0.000257754103343939 0.750406185884892 0.925925925925926 15.1 15 1 abnormal posture 2.13264616567987e-13 9.06830314039091e-12 0.749655779699007 0.925 15.1 15 1 atrioventricular septal defect 2.97084290353987e-09 6.37066527806503e-08 0.749273497302425 0.924528301886792 15.1 15 1 distended pericardium 4.98820999657923e-09 1.04270356020931e-07 0.748097243774477 0.923076923076923 15.1 15 1 liver hypoplasia 4.98820999657923e-09 1.04270356020931e-07 0.748097243774477 0.923076923076923 15.1 15 1 abnormal Mullerian duct morphology 4.64897923108471e-05 0.000413011994190115 0.748097243774477 0.923076923076923 15.1 15 1 increased thymocyte apoptosis 4.64897923108471e-05 0.000413011994190115 0.748097243774477 0.923076923076923 15.1 15 1 absent teeth 0.00513214548861268 0.0237953623540057 0.748097243774477 0.923076923076923 15.1 15 1 absent myocardial trabeculae 0.00513214548861268 0.0237953623540057 0.748097243774477 0.923076923076923 15.1 15 1 abnormal sympathetic ganglion morphology 0.00513214548861268 0.0237953623540057 0.748097243774477 0.923076923076923 15.1 15 1 small trigeminal ganglion 0.00513214548861268 0.0237953623540057 0.748097243774477 0.923076923076923 15.1 15 1 pup cannibalization 0.00513214548861268 0.0237953623540057 0.748097243774477 0.923076923076923 15.1 15 1 abnormal pulmonary alveolus epithelial cell morphology 0.00513214548861268 0.0237953623540057 0.748097243774477 0.923076923076923 15.1 15 1 abnormal lung interstitium morphology 0.00513214548861268 0.0237953623540057 0.748097243774477 0.923076923076923 15.1 15 1 dystrophic cardiac calcinosis 0.00513214548861268 0.0237953623540057 0.748097243774477 0.923076923076923 15.1 15 1 abnormal tail bud morphology 0.00513214548861268 0.0237953623540057 0.748097243774477 0.923076923076923 15.1 15 1 abnormal bile duct development 0.00513214548861268 0.0237953623540057 0.748097243774477 0.923076923076923 15.1 15 1 abnormal coping response 0.00513214548861268 0.0237953623540057 0.748097243774477 0.923076923076923 15.1 15 1 abnormal soleus morphology 0.00513214548861268 0.0237953623540057 0.748097243774477 0.923076923076923 15.1 15 1 abnormal telomere length 0.00513214548861268 0.0237953623540057 0.748097243774477 0.923076923076923 15.1 15 1 tracheoesophageal fistula 0.00513214548861268 0.0237953623540057 0.748097243774477 0.923076923076923 15.1 15 1 muscle fatigue 0.00513214548861268 0.0237953623540057 0.748097243774477 0.923076923076923 15.1 15 1 abnormal exocrine pancreas morphology 0.00513214548861268 0.0237953623540057 0.748097243774477 0.923076923076923 15.1 15 1 abnormal vitelline vasculature morphology 2.40353319058996e-18 1.86837150362267e-16 0.747013044870456 0.921739130434783 15.1 15 1 small lung 8.36287858699568e-09 1.68442595021472e-07 0.746874862657199 0.92156862745098 15.1 15 1 seizures 4.02421251528839e-18 2.96151824881852e-16 0.746456679643393 0.921052631578947 15.1 15 1 decreased hair follicle number 7.88563080084249e-07 1.08372964735335e-05 0.746456679643393 0.921052631578947 15.1 15 1 incomplete somite formation 7.88563080084249e-07 1.08372964735335e-05 0.746456679643393 0.921052631578947 15.1 15 1 decreased total retina thickness 7.88563080084249e-07 1.08372964735335e-05 0.746456679643393 0.921052631578947 15.1 15 1 gliosis 1.52447766022083e-10 4.05576275914365e-09 0.746118150536978 0.920634920634921 15.1 15 1 abnormal nest building behavior 7.80479851548115e-05 0.000655893118488492 0.745603586295229 0.92 15.1 15 1 diaphragmatic hernia 7.80479851548115e-05 0.000655893118488492 0.745603586295229 0.92 15.1 15 1 increased cellular sensitivity to ionizing radiation 7.80479851548115e-05 0.000655893118488492 0.745603586295229 0.92 15.1 15 1 abnormal cochlear outer hair cell morphology 7.80479851548115e-05 0.000655893118488492 0.745603586295229 0.92 15.1 15 1 abnormal vertebrae development 7.80479851548115e-05 0.000655893118488492 0.745603586295229 0.92 15.1 15 1 abnormal CNS synaptic transmission 9.93630768027285e-16 5.554284349366e-14 0.744948686351184 0.919191919191919 15.1 15 1 abnormal maternal nurturing 4.25592870716305e-10 1.06398217679076e-08 0.744009280693742 0.918032786885246 15.1 15 1 abnormal phalanx morphology 3.9030449537208e-08 7.21845674526431e-07 0.742902124026043 0.916666666666667 15.1 15 1 decreased body height 0.000130634429100107 0.00104992937766241 0.742902124026043 0.916666666666667 15.1 15 1 abnormal nursing 0.000130634429100107 0.00104992937766241 0.742902124026043 0.916666666666667 15.1 15 1 abnormal startle reflex 0.000130634429100107 0.00104992937766241 0.742902124026043 0.916666666666667 15.1 15 1 hemolytic anemia 0.000130634429100107 0.00104992937766241 0.742902124026043 0.916666666666667 15.1 15 1 abnormal impulse conducting system conduction 0.000130634429100107 0.00104992937766241 0.742902124026043 0.916666666666667 15.1 15 1 increased hemangiosarcoma incidence 0.000130634429100107 0.00104992937766241 0.742902124026043 0.916666666666667 15.1 15 1 mesocardia 0.00864069009601226 0.0357474372408524 0.742902124026043 0.916666666666667 15.1 15 1 abnormal enteric nervous system morphology 0.00864069009601226 0.0357474372408524 0.742902124026043 0.916666666666667 15.1 15 1 abnormal mating frequency 0.00864069009601226 0.0357474372408524 0.742902124026043 0.916666666666667 15.1 15 1 impaired embryo implantation 0.00864069009601226 0.0357474372408524 0.742902124026043 0.916666666666667 15.1 15 1 altered tumor susceptibility 0.00864069009601226 0.0357474372408524 0.742902124026043 0.916666666666667 15.1 15 1 abnormal respiratory function 0.00864069009601226 0.0357474372408524 0.742902124026043 0.916666666666667 15.1 15 1 decreased synaptic depression 0.00864069009601226 0.0357474372408524 0.742902124026043 0.916666666666667 15.1 15 1 abnormal aorta elastic fiber morphology 0.00864069009601226 0.0357474372408524 0.742902124026043 0.916666666666667 15.1 15 1 loss of dopaminergic neurons 0.00864069009601226 0.0357474372408524 0.742902124026043 0.916666666666667 15.1 15 1 abnormal vascular endothelial cell development 0.00864069009601226 0.0357474372408524 0.742902124026043 0.916666666666667 15.1 15 1 absent ovary 0.00864069009601226 0.0357474372408524 0.742902124026043 0.916666666666667 15.1 15 1 increased osteosarcoma incidence 0.00864069009601226 0.0357474372408524 0.742902124026043 0.916666666666667 15.1 15 1 bowed ulna 0.00864069009601226 0.0357474372408524 0.742902124026043 0.916666666666667 15.1 15 1 stria vascularis degeneration 0.00864069009601226 0.0357474372408524 0.742902124026043 0.916666666666667 15.1 15 1 decreased cochlear nerve compound action potential 0.00864069009601226 0.0357474372408524 0.742902124026043 0.916666666666667 15.1 15 1 hematuria 0.00864069009601226 0.0357474372408524 0.742902124026043 0.916666666666667 15.1 15 1 abnormal somatic nervous system physiology 0.00864069009601226 0.0357474372408524 0.742902124026043 0.916666666666667 15.1 15 1 reduced cerebellar foliation 0.00864069009601226 0.0357474372408524 0.742902124026043 0.916666666666667 15.1 15 1 decreased mammary gland epithelial cell proliferation 0.00864069009601226 0.0357474372408524 0.742902124026043 0.916666666666667 15.1 15 1 prenatal growth retardation 0.00864069009601226 0.0357474372408524 0.742902124026043 0.916666666666667 15.1 15 1 abnormal reflex 2.20434562475491e-06 2.77635936282422e-05 0.742902124026043 0.916666666666667 15.1 15 1 abnormal limb bone morphology 2.20434562475491e-06 2.77635936282422e-05 0.742902124026043 0.916666666666667 15.1 15 1 short radius 2.20434562475491e-06 2.77635936282422e-05 0.742902124026043 0.916666666666667 15.1 15 1 double outlet right ventricle 1.4523386910032e-16 9.14605694650747e-15 0.742270941252869 0.91588785046729 15.1 15 1 abnormal neural tube closure 4.07894381554119e-13 1.63651173244495e-11 0.742088430571469 0.91566265060241 15.1 15 1 perinatal lethality, complete penetrance 1.34674154188553e-31 3.04547235040024e-29 0.741950904917175 0.915492957746479 15.1 15 1 abnormal excitatory postsynaptic potential 6.78343789328855e-13 2.59596950147004e-11 0.741254890935077 0.914634146341463 15.1 15 1 domed cranium 3.63054776647719e-11 1.10133994745268e-09 0.740972508119482 0.914285714285714 15.1 15 1 embryonic lethality between somite formation and embryo turning, complete penetrance 3.63054776647719e-11 1.10133994745268e-09 0.740972508119482 0.914285714285714 15.1 15 1 abnormal dermal layer morphology 3.67315994168271e-06 4.38224717263105e-05 0.740972508119482 0.914285714285714 15.1 15 1 abnormal midbrain development 3.67315994168271e-06 4.38224717263105e-05 0.740972508119482 0.914285714285714 15.1 15 1 abnormal embryonic epiblast morphology 3.67315994168271e-06 4.38224717263105e-05 0.740972508119482 0.914285714285714 15.1 15 1 decreased bone mineralization 3.67315994168271e-06 4.38224717263105e-05 0.740972508119482 0.914285714285714 15.1 15 1 impaired coordination 7.97618656125207e-50 3.60741164929355e-47 0.740169430979179 0.913294797687861 15.1 15 1 abnormal brain morphology 7.71831717353739e-24 1.0378007550905e-21 0.73996575199432 0.91304347826087 15.1 15 1 atrial septal defect 1.0805802099929e-07 1.80398877339418e-06 0.73996575199432 0.91304347826087 15.1 15 1 embryonic lethality between implantation and placentation, complete penetrance 1.0805802099929e-07 1.80398877339418e-06 0.73996575199432 0.91304347826087 15.1 15 1 fragile skeleton 0.000217941355722966 0.00162314108491281 0.73996575199432 0.91304347826087 15.1 15 1 abnormal carpal bone morphology 0.000217941355722966 0.00162314108491281 0.73996575199432 0.91304347826087 15.1 15 1 abnormal cranial nerve morphology 0.000217941355722966 0.00162314108491281 0.73996575199432 0.91304347826087 15.1 15 1 abnormal nasal cavity morphology 0.000217941355722966 0.00162314108491281 0.73996575199432 0.91304347826087 15.1 15 1 abnormal chondrocyte physiology 0.000217941355722966 0.00162314108491281 0.73996575199432 0.91304347826087 15.1 15 1 abnormal hematopoietic stem cell physiology 0.000217941355722966 0.00162314108491281 0.73996575199432 0.91304347826087 15.1 15 1 embryonic lethality, complete penetrance 1.03308991548753e-45 4.28301860795873e-43 0.739302997178382 0.912225705329154 15.1 15 1 preweaning lethality, complete penetrance 6.53873148099451e-105 1.08433963726492e-101 0.739251499337955 0.912162162162162 15.1 15 1 embryonic lethality before implantation, complete penetrance 1.10355024270426e-18 8.85510073782851e-17 0.739120076849184 0.912 15.1 15 1 abnormal embryo size 5.78399187983378e-17 3.78623152660172e-15 0.738718443520667 0.911504424778761 15.1 15 1 abnormal somite development 3.09907549520967e-12 1.09346812685589e-10 0.738627658410243 0.911392405063291 15.1 15 1 abnormal placenta labyrinth morphology 3.09907549520967e-12 1.09346812685589e-10 0.738627658410243 0.911392405063291 15.1 15 1 trabecula carnea hypoplasia 1.79288806791888e-07 2.80491136411837e-06 0.738399686910734 0.911111111111111 15.1 15 1 lethality at weaning, complete penetrance 1.79288806791888e-07 2.80491136411837e-06 0.738399686910734 0.911111111111111 15.1 15 1 ataxia 3.5878425408384e-29 6.61093208913742e-27 0.738221372569534 0.910891089108911 15.1 15 1 abnormal hepatocyte morphology 1.58454565652754e-16 9.85389330153066e-15 0.73742618699391 0.90990990990991 15.1 15 1 increased body size 0.000362316763975132 0.00248624262176039 0.736762437050621 0.909090909090909 15.1 15 1 abnormal tail movements 0.000362316763975132 0.00248624262176039 0.736762437050621 0.909090909090909 15.1 15 1 abnormal oogenesis 0.000362316763975132 0.00248624262176039 0.736762437050621 0.909090909090909 15.1 15 1 increased myocardial infarction size 0.000362316763975132 0.00248624262176039 0.736762437050621 0.909090909090909 15.1 15 1 abnormal lysosome physiology 0.000362316763975132 0.00248624262176039 0.736762437050621 0.909090909090909 15.1 15 1 abnormal vascular branching morphogenesis 0.000362316763975132 0.00248624262176039 0.736762437050621 0.909090909090909 15.1 15 1 abnormal channel response 0.000362316763975132 0.00248624262176039 0.736762437050621 0.909090909090909 15.1 15 1 prolonged PR interval 0.000362316763975132 0.00248624262176039 0.736762437050621 0.909090909090909 15.1 15 1 abnormal basement membrane morphology 0.000362316763975132 0.00248624262176039 0.736762437050621 0.909090909090909 15.1 15 1 abnormal blood-brain barrier function 0.000362316763975132 0.00248624262176039 0.736762437050621 0.909090909090909 15.1 15 1 increased circulating creatine kinase level 0.000362316763975132 0.00248624262176039 0.736762437050621 0.909090909090909 15.1 15 1 embryonic lethality before implantation, incomplete penetrance 0.000362316763975132 0.00248624262176039 0.736762437050621 0.909090909090909 15.1 15 1 decreased atrioventricular cushion size 0.0144644095356547 0.055610848098827 0.736762437050621 0.909090909090909 15.1 15 1 delayed hepatic development 0.0144644095356547 0.055610848098827 0.736762437050621 0.909090909090909 15.1 15 1 abnormal enteric ganglia morphology 0.0144644095356547 0.055610848098827 0.736762437050621 0.909090909090909 15.1 15 1 focal hepatic necrosis 0.0144644095356547 0.055610848098827 0.736762437050621 0.909090909090909 15.1 15 1 loss of cortex neurons 0.0144644095356547 0.055610848098827 0.736762437050621 0.909090909090909 15.1 15 1 pulmonary hypertension 0.0144644095356547 0.055610848098827 0.736762437050621 0.909090909090909 15.1 15 1 dilated renal glomerular capsule 0.0144644095356547 0.055610848098827 0.736762437050621 0.909090909090909 15.1 15 1 abnormal pituitary gland development 0.0144644095356547 0.055610848098827 0.736762437050621 0.909090909090909 15.1 15 1 abnormal crista ampullaris neuroepithelium morphology 0.0144644095356547 0.055610848098827 0.736762437050621 0.909090909090909 15.1 15 1 abnormal spinal cord ventral horn morphology 0.0144644095356547 0.055610848098827 0.736762437050621 0.909090909090909 15.1 15 1 cyclopia 0.0144644095356547 0.055610848098827 0.736762437050621 0.909090909090909 15.1 15 1 abnormal dorsal-ventral polarity of the somites 0.0144644095356547 0.055610848098827 0.736762437050621 0.909090909090909 15.1 15 1 abnormal palate development 0.0144644095356547 0.055610848098827 0.736762437050621 0.909090909090909 15.1 15 1 palatal shelf hypoplasia 0.0144644095356547 0.055610848098827 0.736762437050621 0.909090909090909 15.1 15 1 aorta dilation 0.0144644095356547 0.055610848098827 0.736762437050621 0.909090909090909 15.1 15 1 abnormal pulmonary alveolar sac morphology 0.0144644095356547 0.055610848098827 0.736762437050621 0.909090909090909 15.1 15 1 enlarged pericardium 1.01241328919185e-05 0.000109020695102369 0.736762437050621 0.909090909090909 15.1 15 1 decreased brown adipose tissue amount 1.01241328919185e-05 0.000109020695102369 0.736762437050621 0.909090909090909 15.1 15 1 increased cardiomyocyte apoptosis 1.01241328919185e-05 0.000109020695102369 0.736762437050621 0.909090909090909 15.1 15 1 embryonic lethality during organogenesis, complete penetrance 8.76512138888529e-78 7.26774648495072e-75 0.73663087232972 0.908928571428571 15.1 15 1 decreased cell proliferation 2.31581317145929e-26 3.7165066219387e-24 0.735965937118675 0.908108108108108 15.1 15 1 abnormal axial skeleton morphology 1.4007655744461e-11 4.49600563410927e-10 0.735793012791344 0.907894736842105 15.1 15 1 impaired limb coordination 1.47705731822561e-08 2.89305518038284e-07 0.735398062167194 0.907407407407407 15.1 15 1 axon degeneration 1.47705731822561e-08 2.89305518038284e-07 0.735398062167194 0.907407407407407 15.1 15 1 abnormal double-strand DNA break repair 4.90569761161596e-07 7.01317402810041e-06 0.735049036034225 0.906976744186046 15.1 15 1 abnormal limb morphology 2.31018647921368e-11 7.27416312284055e-10 0.734797737218486 0.906666666666667 15.1 15 1 neonatal lethality 1.67412915284403e-05 0.000168599039178118 0.734460054434838 0.90625 15.1 15 1 abnormal long term potentiation 1.67412915284403e-05 0.000168599039178118 0.734460054434838 0.90625 15.1 15 1 abnormal lumbar vertebrae morphology 1.67412915284403e-05 0.000168599039178118 0.734460054434838 0.90625 15.1 15 1 abnormal depression-related behavior 1.67412915284403e-05 0.000168599039178118 0.734460054434838 0.90625 15.1 15 1 abnormal embryonic hematopoiesis 1.67412915284403e-05 0.000168599039178118 0.734460054434838 0.90625 15.1 15 1 abnormal erythropoiesis 3.18803868553106e-15 1.6872864319699e-13 0.733254044493238 0.904761904761905 15.1 15 1 spina bifida 8.08855811914915e-07 1.10459443898705e-05 0.733254044493238 0.904761904761905 15.1 15 1 abnormal associative learning 0.000600024445065559 0.00393296655362471 0.733254044493238 0.904761904761905 15.1 15 1 liver degeneration 0.000600024445065559 0.00393296655362471 0.733254044493238 0.904761904761905 15.1 15 1 left pulmonary isomerism 0.000600024445065559 0.00393296655362471 0.733254044493238 0.904761904761905 15.1 15 1 vascular ring 0.000600024445065559 0.00393296655362471 0.733254044493238 0.904761904761905 15.1 15 1 abnormal cell cycle 1.65932800139295e-16 1.01915516134937e-14 0.732918459118183 0.904347826086957 15.1 15 1 embryonic growth arrest 1.83857927941904e-31 3.81122163129572e-29 0.732579942866491 0.903930131004367 15.1 15 1 decreased kidney weight 4.00847633369102e-08 7.38598880004179e-07 0.732511884529176 0.903846153846154 15.1 15 1 decreased embryo size 2.77724933468621e-64 1.97383077715199e-61 0.732446673821036 0.903765690376569 15.1 15 1 osteopetrosis 2.76041213566756e-05 0.000257754103343939 0.732009131005134 0.903225806451613 15.1 15 1 abnormal eyelid morphology 2.76041213566756e-05 0.000257754103343939 0.732009131005134 0.903225806451613 15.1 15 1 abnormal object recognition memory 2.76041213566756e-05 0.000257754103343939 0.732009131005134 0.903225806451613 15.1 15 1 abnormal postnatal growth/weight/body size 2.76041213566756e-05 0.000257754103343939 0.732009131005134 0.903225806451613 15.1 15 1 abnormal capillary morphology 2.76041213566756e-05 0.000257754103343939 0.732009131005134 0.903225806451613 15.1 15 1 pale kidney 2.76041213566756e-05 0.000257754103343939 0.732009131005134 0.903225806451613 15.1 15 1 abnormal craniofacial morphology 8.60451287448043e-15 4.20402872316835e-13 0.731755313692025 0.902912621359223 15.1 15 1 abnormal forebrain development 1.02800293934602e-10 2.88944328996974e-09 0.73164603123777 0.902777777777778 15.1 15 1 thick ventricular wall 1.33059819763112e-06 1.75125027333725e-05 0.731371492389276 0.902439024390244 15.1 15 1 short humerus 1.33059819763112e-06 1.75125027333725e-05 0.731371492389276 0.902439024390244 15.1 15 1 short ulna 1.33059819763112e-06 1.75125027333725e-05 0.731371492389276 0.902439024390244 15.1 15 1 preweaning lethality, incomplete penetrance 1.39020599293718e-54 7.68474979429161e-52 0.731178174080311 0.902200488997555 15.1 15 1 abnormal locomotor behavior 2.72300517100678e-13 1.1289125604799e-11 0.731156635899149 0.902173913043478 15.1 15 1 abnormal cued conditioning behavior 6.58481879243507e-08 1.14144506942037e-06 0.730983908132577 0.901960784313726 15.1 15 1 abnormal response to novel object 6.58481879243507e-08 1.14144506942037e-06 0.730983908132577 0.901960784313726 15.1 15 1 abnormal trophoblast layer morphology 6.58481879243507e-08 1.14144506942037e-06 0.730983908132577 0.901960784313726 15.1 15 1 perinatal lethality 2.18363504310117e-06 2.77132253556844e-05 0.729394812680115 0.9 15.1 15 1 abnormal cell proliferation 0.000989526548057434 0.00599621751106667 0.729394812680115 0.9 15.1 15 1 abnormal circulating enzyme level 0.000989526548057434 0.00599621751106667 0.729394812680115 0.9 15.1 15 1 increased mammary adenocarcinoma incidence 0.000989526548057434 0.00599621751106667 0.729394812680115 0.9 15.1 15 1 absent placental labyrinth 0.000989526548057434 0.00599621751106667 0.729394812680115 0.9 15.1 15 1 abnormal heart right ventricle morphology 0.000989526548057434 0.00599621751106667 0.729394812680115 0.9 15.1 15 1 abnormal neuron proliferation 0.000989526548057434 0.00599621751106667 0.729394812680115 0.9 15.1 15 1 retarded hair growth 0.0240508941490444 0.0840851710411075 0.729394812680115 0.9 15.1 15 1 kidney hemorrhage 0.0240508941490444 0.0840851710411075 0.729394812680115 0.9 15.1 15 1 small petrosal ganglion 0.0240508941490444 0.0840851710411075 0.729394812680115 0.9 15.1 15 1 absent trophoblast giant cells 0.0240508941490444 0.0840851710411075 0.729394812680115 0.9 15.1 15 1 rhinitis 0.0240508941490444 0.0840851710411075 0.729394812680115 0.9 15.1 15 1 alcohol preference 0.0240508941490444 0.0840851710411075 0.729394812680115 0.9 15.1 15 1 decreased incidence of induced tumors 0.0240508941490444 0.0840851710411075 0.729394812680115 0.9 15.1 15 1 abnormal respiratory mechanics 0.0240508941490444 0.0840851710411075 0.729394812680115 0.9 15.1 15 1 ketoaciduria 0.0240508941490444 0.0840851710411075 0.729394812680115 0.9 15.1 15 1 impaired social transmission of food preference 0.0240508941490444 0.0840851710411075 0.729394812680115 0.9 15.1 15 1 impaired basement membrane formation 0.0240508941490444 0.0840851710411075 0.729394812680115 0.9 15.1 15 1 abnormal tibialis anterior morphology 0.0240508941490444 0.0840851710411075 0.729394812680115 0.9 15.1 15 1 aneurysm 0.0240508941490444 0.0840851710411075 0.729394812680115 0.9 15.1 15 1 bifid ureter 0.0240508941490444 0.0840851710411075 0.729394812680115 0.9 15.1 15 1 cochlear ganglion hypoplasia 0.0240508941490444 0.0840851710411075 0.729394812680115 0.9 15.1 15 1 absent seminal vesicle 0.0240508941490444 0.0840851710411075 0.729394812680115 0.9 15.1 15 1 abnormal submandibular gland morphology 0.0240508941490444 0.0840851710411075 0.729394812680115 0.9 15.1 15 1 increased left ventricle diastolic pressure 0.0240508941490444 0.0840851710411075 0.729394812680115 0.9 15.1 15 1 abnormal hindlimb zeugopod morphology 0.0240508941490444 0.0840851710411075 0.729394812680115 0.9 15.1 15 1 absent pharyngeal arches 0.0240508941490444 0.0840851710411075 0.729394812680115 0.9 15.1 15 1 abnormal reproductive system development 0.0240508941490444 0.0840851710411075 0.729394812680115 0.9 15.1 15 1 abnormal gas homeostasis 0.0240508941490444 0.0840851710411075 0.729394812680115 0.9 15.1 15 1 abnormal placental transport 0.0240508941490444 0.0840851710411075 0.729394812680115 0.9 15.1 15 1 abnormal utricular macula morphology 0.0240508941490444 0.0840851710411075 0.729394812680115 0.9 15.1 15 1 abnormal cochlear inner hair cell physiology 0.0240508941490444 0.0840851710411075 0.729394812680115 0.9 15.1 15 1 abnormal corneal endothelium morphology 0.0240508941490444 0.0840851710411075 0.729394812680115 0.9 15.1 15 1 abnormal developmental vascular remodeling 0.0240508941490444 0.0840851710411075 0.729394812680115 0.9 15.1 15 1 impaired behavioral response to morphine 0.0240508941490444 0.0840851710411075 0.729394812680115 0.9 15.1 15 1 protruding tongue 0.0240508941490444 0.0840851710411075 0.729394812680115 0.9 15.1 15 1 decreased transitional stage T2 B cell number 0.0240508941490444 0.0840851710411075 0.729394812680115 0.9 15.1 15 1 abnormal retinal blood vessel pattern 0.0240508941490444 0.0840851710411075 0.729394812680115 0.9 15.1 15 1 acanthocytosis 0.0240508941490444 0.0840851710411075 0.729394812680115 0.9 15.1 15 1 common ventricle 0.0240508941490444 0.0840851710411075 0.729394812680115 0.9 15.1 15 1 thick aortic valve cusps 0.0240508941490444 0.0840851710411075 0.729394812680115 0.9 15.1 15 1 thick aortic valve 0.0240508941490444 0.0840851710411075 0.729394812680115 0.9 15.1 15 1 fusion of atlas and odontoid process 0.0240508941490444 0.0840851710411075 0.729394812680115 0.9 15.1 15 1 decreased trabecular bone connectivity density 0.0240508941490444 0.0840851710411075 0.729394812680115 0.9 15.1 15 1 increased compact bone area 0.0240508941490444 0.0840851710411075 0.729394812680115 0.9 15.1 15 1 abnormal circadian temperature homeostasis 0.0240508941490444 0.0840851710411075 0.729394812680115 0.9 15.1 15 1 lethality during fetal growth through weaning, complete penetrance 0.0240508941490444 0.0840851710411075 0.729394812680115 0.9 15.1 15 1 increased B cell derived lymphoma incidence 1.07956312836705e-07 1.80398877339418e-06 0.729394812680115 0.9 15.1 15 1 abnormal axon extension 1.07956312836705e-07 1.80398877339418e-06 0.729394812680115 0.9 15.1 15 1 abnormal brain vasculature morphology 4.53767770108698e-05 0.000404568934819135 0.729394812680115 0.9 15.1 15 1 lethality throughout fetal growth and development, incomplete penetrance 3.45273809308792e-24 4.77149222586456e-22 0.728942053640587 0.899441340782123 15.1 15 1 abnormal behavior 8.71546902659854e-37 2.55055637690163e-34 0.7288117632695 0.899280575539568 15.1 15 1 abnormal neuron morphology 6.19054846338678e-14 2.87831575750927e-12 0.728576187750059 0.898989898989899 15.1 15 1 anophthalmia 1.19465450287481e-12 4.43537772522549e-11 0.728484207420839 0.898876404494382 15.1 15 1 decreased rib number 1.19465450287481e-12 4.43537772522549e-11 0.728484207420839 0.898876404494382 15.1 15 1 syndactyly 8.87926759579608e-09 1.77407053369821e-07 0.728021187797479 0.898305084745763 15.1 15 1 absent kidney 1.76627199803269e-07 2.78076050323185e-06 0.727740856188777 0.897959183673469 15.1 15 1 embryonic lethality between implantation and somite formation, complete penetrance 2.67646059126298e-32 6.34066259120634e-30 0.727740856188777 0.897959183673469 15.1 15 1 small liver 3.78145938273022e-11 1.12651260054388e-09 0.727316764780742 0.897435897435897 15.1 15 1 absent gastric milk in neonates 3.78145938273022e-11 1.12651260054388e-09 0.727316764780742 0.897435897435897 15.1 15 1 increased hepatocyte apoptosis 3.57452797069121e-06 4.31632928499727e-05 0.727316764780742 0.897435897435897 15.1 15 1 aphagia 7.43500429187866e-05 0.00063549010167421 0.726600196539578 0.896551724137931 15.1 15 1 decreased trophoblast giant cell number 7.43500429187866e-05 0.00063549010167421 0.726600196539578 0.896551724137931 15.1 15 1 short sternum 7.43500429187866e-05 0.00063549010167421 0.726600196539578 0.896551724137931 15.1 15 1 oligodactyly 2.88360618674043e-07 4.30809032403413e-06 0.726017984843633 0.895833333333333 15.1 15 1 small heart 2.88360618674043e-07 4.30809032403413e-06 0.726017984843633 0.895833333333333 15.1 15 1 vertebral transformation 2.88360618674043e-07 4.30809032403413e-06 0.726017984843633 0.895833333333333 15.1 15 1 curly tail 2.88360618674043e-07 4.30809032403413e-06 0.726017984843633 0.895833333333333 15.1 15 1 thymus atrophy 2.88360618674043e-07 4.30809032403413e-06 0.726017984843633 0.895833333333333 15.1 15 1 rib fusion 1.20199191004614e-09 2.79435035162596e-08 0.725765982766284 0.895522388059702 15.1 15 1 internal hemorrhage 1.20199191004614e-09 2.79435035162596e-08 0.725765982766284 0.895522388059702 15.1 15 1 edema 1.06543055962013e-22 1.26202786526432e-20 0.725625330444042 0.895348837209302 15.1 15 1 persistence of hyaloid vascular system 5.83589019102886e-06 6.70520870678258e-05 0.725129345939296 0.894736842105263 15.1 15 1 small superior vagus ganglion 0.00162438106276568 0.00912110134002172 0.725129345939296 0.894736842105263 15.1 15 1 shiny skin 0.00162438106276568 0.00912110134002172 0.725129345939296 0.894736842105263 15.1 15 1 decreased chemically-elicited antinociception 0.00162438106276568 0.00912110134002172 0.725129345939296 0.894736842105263 15.1 15 1 abnormal neurotransmitter level 0.00162438106276568 0.00912110134002172 0.725129345939296 0.894736842105263 15.1 15 1 maternal imprinting 0.00162438106276568 0.00912110134002172 0.725129345939296 0.894736842105263 15.1 15 1 abnormal optic vesicle formation 0.00162438106276568 0.00912110134002172 0.725129345939296 0.894736842105263 15.1 15 1 decreased liver regeneration 0.00162438106276568 0.00912110134002172 0.725129345939296 0.894736842105263 15.1 15 1 decreased fertilization frequency 0.00162438106276568 0.00912110134002172 0.725129345939296 0.894736842105263 15.1 15 1 abnormal cell nucleus morphology 4.69725723286046e-07 6.73454026901463e-06 0.724221799824228 0.893617021276596 15.1 15 1 cleft palate 2.2776492175785e-17 1.5108406476604e-15 0.723826913346679 0.893129770992366 15.1 15 1 enhanced long term potentiation 3.84236317988609e-08 7.13274508206467e-07 0.723605964960432 0.892857142857143 15.1 15 1 abnormal jaw morphology 0.000121400627422404 0.00098526610346894 0.723605964960432 0.892857142857143 15.1 15 1 abnormal somite shape 0.000121400627422404 0.00098526610346894 0.723605964960432 0.892857142857143 15.1 15 1 straub tail 0.000121400627422404 0.00098526610346894 0.723605964960432 0.892857142857143 15.1 15 1 premature aging 0.000121400627422404 0.00098526610346894 0.723605964960432 0.892857142857143 15.1 15 1 abnormal mitotic spindle morphology 0.000121400627422404 0.00098526610346894 0.723605964960432 0.892857142857143 15.1 15 1 prolonged QRS complex duration 0.000121400627422404 0.00098526610346894 0.723605964960432 0.892857142857143 15.1 15 1 kinked tail 9.77010178697029e-14 4.50057929538678e-12 0.723038430870267 0.892156862745098 15.1 15 1 kidney cysts 2.65007086928707e-10 6.79592916221813e-09 0.722823688241556 0.891891891891892 15.1 15 1 increased circulating phosphate level 9.50134649562543e-06 0.000103207857676281 0.722823688241556 0.891891891891892 15.1 15 1 abnormal breathing pattern 9.50134649562543e-06 0.000103207857676281 0.722823688241556 0.891891891891892 15.1 15 1 impaired skeletal muscle contractility 9.50134649562543e-06 0.000103207857676281 0.722823688241556 0.891891891891892 15.1 15 1 abnormal myelin sheath morphology 7.63381250291198e-07 1.05788905855117e-05 0.722347519803979 0.891304347826087 15.1 15 1 abnormal pulmonary alveolus morphology 1.58384973370522e-13 6.85187167407257e-12 0.7221730818615 0.891089108910891 15.1 15 1 abnormal fertility/fecundity 4.29541279164066e-10 1.06848393192062e-08 0.72162348286465 0.89041095890411 15.1 15 1 abnormal embryo development 1.33960758391132e-17 9.52078247136976e-16 0.721052061554689 0.889705882352941 15.1 15 1 abnormal motor coordination/ balance 4.14760939095914e-13 1.65074853760174e-11 0.720389938449497 0.888888888888889 15.1 15 1 increased exploration in new environment 5.82642245142707e-11 1.69511413426021e-09 0.720389938449497 0.888888888888889 15.1 15 1 abnormal cell adhesion 1.01029821349764e-07 1.71543809288421e-06 0.720389938449497 0.888888888888889 15.1 15 1 abnormal neuronal precursor proliferation 1.01029821349764e-07 1.71543809288421e-06 0.720389938449497 0.888888888888889 15.1 15 1 abnormal atrioventricular cushion morphology 0.00019749084503711 0.00150924263296409 0.720389938449497 0.888888888888889 15.1 15 1 abnormal trigeminal nerve morphology 0.00019749084503711 0.00150924263296409 0.720389938449497 0.888888888888889 15.1 15 1 decreased susceptibility to pharmacologically induced seizures 0.00019749084503711 0.00150924263296409 0.720389938449497 0.888888888888889 15.1 15 1 decreased circulating fructosamine level 0.00019749084503711 0.00150924263296409 0.720389938449497 0.888888888888889 15.1 15 1 thick interventricular septum 0.00019749084503711 0.00150924263296409 0.720389938449497 0.888888888888889 15.1 15 1 decreased bone ossification 0.00019749084503711 0.00150924263296409 0.720389938449497 0.888888888888889 15.1 15 1 abnormal heart shape 0.00265306282601664 0.0137632821266244 0.720389938449497 0.888888888888889 15.1 15 1 underdeveloped hair follicles 0.00265306282601664 0.0137632821266244 0.720389938449497 0.888888888888889 15.1 15 1 abnormal thyroid cartilage morphology 0.00265306282601664 0.0137632821266244 0.720389938449497 0.888888888888889 15.1 15 1 abnormal thymus cortex morphology 0.00265306282601664 0.0137632821266244 0.720389938449497 0.888888888888889 15.1 15 1 abnormal thymus medulla morphology 0.00265306282601664 0.0137632821266244 0.720389938449497 0.888888888888889 15.1 15 1 increased circulating renin level 0.00265306282601664 0.0137632821266244 0.720389938449497 0.888888888888889 15.1 15 1 darkened coat color 0.00265306282601664 0.0137632821266244 0.720389938449497 0.888888888888889 15.1 15 1 jerky movement 0.00265306282601664 0.0137632821266244 0.720389938449497 0.888888888888889 15.1 15 1 atrioventricular block 0.00265306282601664 0.0137632821266244 0.720389938449497 0.888888888888889 15.1 15 1 increased effector memory CD8-positive, alpha-beta T cell number 0.00265306282601664 0.0137632821266244 0.720389938449497 0.888888888888889 15.1 15 1 abnormal aerobic respiration 0.00265306282601664 0.0137632821266244 0.720389938449497 0.888888888888889 15.1 15 1 increased adipocyte glucose uptake 0.00265306282601664 0.0137632821266244 0.720389938449497 0.888888888888889 15.1 15 1 distorted hair follicle pattern 0.0396731277454484 0.12266862059267 0.720389938449497 0.888888888888889 15.1 15 1 renal tubular acidosis 0.0396731277454484 0.12266862059267 0.720389938449497 0.888888888888889 15.1 15 1 synostosis 0.0396731277454484 0.12266862059267 0.720389938449497 0.888888888888889 15.1 15 1 abnormal sympathetic neuron morphology 0.0396731277454484 0.12266862059267 0.720389938449497 0.888888888888889 15.1 15 1 abnormal cholinergic neuron morphology 0.0396731277454484 0.12266862059267 0.720389938449497 0.888888888888889 15.1 15 1 small geniculate ganglion 0.0396731277454484 0.12266862059267 0.720389938449497 0.888888888888889 15.1 15 1 small nodose ganglion 0.0396731277454484 0.12266862059267 0.720389938449497 0.888888888888889 15.1 15 1 psoriasis 0.0396731277454484 0.12266862059267 0.720389938449497 0.888888888888889 15.1 15 1 abnormal kindling response 0.0396731277454484 0.12266862059267 0.720389938449497 0.888888888888889 15.1 15 1 abnormal ion homeostasis 0.0396731277454484 0.12266862059267 0.720389938449497 0.888888888888889 15.1 15 1 decreased level of surface class I molecules 0.0396731277454484 0.12266862059267 0.720389938449497 0.888888888888889 15.1 15 1 abnormal germ cell morphology 0.0396731277454484 0.12266862059267 0.720389938449497 0.888888888888889 15.1 15 1 abnormal vomeronasal organ morphology 0.0396731277454484 0.12266862059267 0.720389938449497 0.888888888888889 15.1 15 1 polycythemia 0.0396731277454484 0.12266862059267 0.720389938449497 0.888888888888889 15.1 15 1 decreased circulating bicarbonate level 0.0396731277454484 0.12266862059267 0.720389938449497 0.888888888888889 15.1 15 1 genetic imprinting 0.0396731277454484 0.12266862059267 0.720389938449497 0.888888888888889 15.1 15 1 absent posterior semicircular canal 0.0396731277454484 0.12266862059267 0.720389938449497 0.888888888888889 15.1 15 1 biliary cyst 0.0396731277454484 0.12266862059267 0.720389938449497 0.888888888888889 15.1 15 1 abnormal artery development 0.0396731277454484 0.12266862059267 0.720389938449497 0.888888888888889 15.1 15 1 premature bone ossification 0.0396731277454484 0.12266862059267 0.720389938449497 0.888888888888889 15.1 15 1 abnormal CNS synapse formation 0.0396731277454484 0.12266862059267 0.720389938449497 0.888888888888889 15.1 15 1 abnormal gallbladder physiology 0.0396731277454484 0.12266862059267 0.720389938449497 0.888888888888889 15.1 15 1 abnormal intervertebral disk development 0.0396731277454484 0.12266862059267 0.720389938449497 0.888888888888889 15.1 15 1 hemothorax 0.0396731277454484 0.12266862059267 0.720389938449497 0.888888888888889 15.1 15 1 abnormal oxygen consumption 0.0396731277454484 0.12266862059267 0.720389938449497 0.888888888888889 15.1 15 1 positive geotaxis 0.0396731277454484 0.12266862059267 0.720389938449497 0.888888888888889 15.1 15 1 abnormal hyoid bone lesser horn morphology 0.0396731277454484 0.12266862059267 0.720389938449497 0.888888888888889 15.1 15 1 decreased transitional stage T1 B cell number 0.0396731277454484 0.12266862059267 0.720389938449497 0.888888888888889 15.1 15 1 abnormal cerebellar layer morphology 0.0396731277454484 0.12266862059267 0.720389938449497 0.888888888888889 15.1 15 1 axonal spheroids 0.0396731277454484 0.12266862059267 0.720389938449497 0.888888888888889 15.1 15 1 abnormal telomere morphology 0.0396731277454484 0.12266862059267 0.720389938449497 0.888888888888889 15.1 15 1 retropulsion 0.0396731277454484 0.12266862059267 0.720389938449497 0.888888888888889 15.1 15 1 abnormal ventricle myocardium morphology 0.0396731277454484 0.12266862059267 0.720389938449497 0.888888888888889 15.1 15 1 iris coloboma 0.0396731277454484 0.12266862059267 0.720389938449497 0.888888888888889 15.1 15 1 fusion of atlas and occipital bones 0.0396731277454484 0.12266862059267 0.720389938449497 0.888888888888889 15.1 15 1 abnormal pulmonary alveolar system morphology 0.0396731277454484 0.12266862059267 0.720389938449497 0.888888888888889 15.1 15 1 decreased airway resistance 0.0396731277454484 0.12266862059267 0.720389938449497 0.888888888888889 15.1 15 1 abnormal oxidative phosphorylation 0.0396731277454484 0.12266862059267 0.720389938449497 0.888888888888889 15.1 15 1 abnormal lung lobe morphology 0.0396731277454484 0.12266862059267 0.720389938449497 0.888888888888889 15.1 15 1 increased myeloid cell number 0.0396731277454484 0.12266862059267 0.720389938449497 0.888888888888889 15.1 15 1 trigeminal neuroma 0.0396731277454484 0.12266862059267 0.720389938449497 0.888888888888889 15.1 15 1 abnormal coronary sinus connection 0.0396731277454484 0.12266862059267 0.720389938449497 0.888888888888889 15.1 15 1 decreased fatty acid oxidation 0.0396731277454484 0.12266862059267 0.720389938449497 0.888888888888889 15.1 15 1 enhanced leukocyte tethering or rolling 0.0396731277454484 0.12266862059267 0.720389938449497 0.888888888888889 15.1 15 1 increased endoplasmic reticulum stress 0.0396731277454484 0.12266862059267 0.720389938449497 0.888888888888889 15.1 15 1 adipose tissue inflammation 0.0396731277454484 0.12266862059267 0.720389938449497 0.888888888888889 15.1 15 1 polydactyly 6.69955192437642e-13 2.58374192432346e-11 0.719471073732087 0.887755102040816 15.1 15 1 increased startle reflex 7.92619206177612e-12 2.66437875049569e-10 0.719378154828079 0.887640449438202 15.1 15 1 hyperactivity 8.29214574998312e-45 3.173340392782e-42 0.718690905575795 0.886792452830189 15.1 15 1 increased circulating bilirubin level 1.63301759106272e-07 2.58734475017104e-06 0.718690905575795 0.886792452830189 15.1 15 1 abnormal gait 1.6244998318752e-37 5.05117916473694e-35 0.718641419181415 0.886731391585761 15.1 15 1 abnormal heart development 9.14540669696835e-20 8.74969198411876e-18 0.718110223454403 0.886075949367089 15.1 15 1 abnormal placenta morphology 1.51813752013105e-10 4.05576275914365e-09 0.718110223454403 0.886075949367089 15.1 15 1 pallor 1.07797221883814e-21 1.16585038885212e-19 0.717817117240748 0.885714285714286 15.1 15 1 increased circulating serum albumin level 2.49600144395138e-05 0.0002390869031263 0.717817117240748 0.885714285714286 15.1 15 1 decreased triglyceride level 2.49600144395138e-05 0.0002390869031263 0.717817117240748 0.885714285714286 15.1 15 1 decreased glycogen level 2.49600144395138e-05 0.0002390869031263 0.717817117240748 0.885714285714286 15.1 15 1 increased red blood cell distribution width 2.49600144395138e-05 0.0002390869031263 0.717817117240748 0.885714285714286 15.1 15 1 prenatal lethality, incomplete penetrance 1.77919189825929e-36 4.91748871879999e-34 0.71713159580026 0.884868421052632 15.1 15 1 abnormal nasal bone morphology 0.000319994130291874 0.00228076045587689 0.716926525283874 0.884615384615385 15.1 15 1 ventricular hypoplasia 0.000319994130291874 0.00228076045587689 0.716926525283874 0.884615384615385 15.1 15 1 thick skin 0.000319994130291874 0.00228076045587689 0.716926525283874 0.884615384615385 15.1 15 1 increased susceptibility to otitis media 0.000319994130291874 0.00228076045587689 0.716926525283874 0.884615384615385 15.1 15 1 decreased circulating glycerol level 0.000319994130291874 0.00228076045587689 0.716926525283874 0.884615384615385 15.1 15 1 pulmonary edema 0.000319994130291874 0.00228076045587689 0.716926525283874 0.884615384615385 15.1 15 1 decreased bone resorption 0.000319994130291874 0.00228076045587689 0.716926525283874 0.884615384615385 15.1 15 1 abnormal sternum morphology 2.91622754804268e-09 6.28061993571963e-08 0.716474775740532 0.884057971014493 15.1 15 1 microcephaly 2.91622754804268e-09 6.28061993571963e-08 0.716474775740532 0.884057971014493 15.1 15 1 kidney failure 3.22782979764011e-06 3.92627218661603e-05 0.71620162485386 0.883720930232558 15.1 15 1 abnormal neural tube morphology 8.42478922645868e-20 8.21829929443763e-18 0.715387230543597 0.882716049382716 15.1 15 1 impaired balance 6.13514639626662e-13 2.38455885323644e-11 0.715092953607956 0.882352941176471 15.1 15 1 abnormal extraembryonic tissue morphology 6.13514639626662e-13 2.38455885323644e-11 0.715092953607956 0.882352941176471 15.1 15 1 distended abdomen 4.23767249679358e-07 6.12861066033374e-06 0.715092953607956 0.882352941176471 15.1 15 1 failure of chorioallantoic fusion 4.23767249679358e-07 6.12861066033374e-06 0.715092953607956 0.882352941176471 15.1 15 1 lung hemorrhage 4.02605547348318e-05 0.000362199384820594 0.715092953607956 0.882352941176471 15.1 15 1 overexpanded pulmonary alveoli 4.02605547348318e-05 0.000362199384820594 0.715092953607956 0.882352941176471 15.1 15 1 abnormal direction of heart looping 4.02605547348318e-05 0.000362199384820594 0.715092953607956 0.882352941176471 15.1 15 1 abnormal adipose tissue morphology 0.00430894579181806 0.0209345755022411 0.715092953607956 0.882352941176471 15.1 15 1 abnormal urinary bladder morphology 0.00430894579181806 0.0209345755022411 0.715092953607956 0.882352941176471 15.1 15 1 abnormal cranial suture morphology 0.00430894579181806 0.0209345755022411 0.715092953607956 0.882352941176471 15.1 15 1 abnormal tarsal bone morphology 0.00430894579181806 0.0209345755022411 0.715092953607956 0.882352941176471 15.1 15 1 coloboma 0.00430894579181806 0.0209345755022411 0.715092953607956 0.882352941176471 15.1 15 1 enhanced behavioral response to cocaine 0.00430894579181806 0.0209345755022411 0.715092953607956 0.882352941176471 15.1 15 1 increased trabecular bone mass 0.00430894579181806 0.0209345755022411 0.715092953607956 0.882352941176471 15.1 15 1 delayed heart development 0.00430894579181806 0.0209345755022411 0.715092953607956 0.882352941176471 15.1 15 1 abnormal ductus venosus valve morphology 0.00430894579181806 0.0209345755022411 0.715092953607956 0.882352941176471 15.1 15 1 abnormal reproductive system morphology 5.191491851931e-06 6.04863512022406e-05 0.713957885427626 0.880952380952381 15.1 15 1 increased bone mineral content 1.34236065470565e-13 5.85810899750929e-12 0.713780856445373 0.880733944954128 15.1 15 1 abnormal interventricular septum morphology 6.80213704224738e-07 9.50579544527548e-06 0.713186039065002 0.88 15.1 15 1 decreased circulating alkaline phosphatase level 6.80213704224738e-07 9.50579544527548e-06 0.713186039065002 0.88 15.1 15 1 mandible hypoplasia 0.000516268351365603 0.00341093631878337 0.713186039065002 0.88 15.1 15 1 abnormal thyroid gland morphology 0.000516268351365603 0.00341093631878337 0.713186039065002 0.88 15.1 15 1 abnormal egg cylinder morphology 0.000516268351365603 0.00341093631878337 0.713186039065002 0.88 15.1 15 1 decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 0.000516268351365603 0.00341093631878337 0.713186039065002 0.88 15.1 15 1 kyphosis 4.04790434009366e-18 2.96151824881852e-16 0.713186039065002 0.88 15.1 15 1 short tail 1.36646566121086e-10 3.6746846835265e-09 0.712795466206806 0.879518072289157 15.1 15 1 pale yolk sac 1.36646566121086e-10 3.6746846835265e-09 0.712795466206806 0.879518072289157 15.1 15 1 abnormal embryonic neuroepithelium morphology 9.012273158756e-08 1.54075804002787e-06 0.712627115836894 0.879310344827586 15.1 15 1 lethality throughout fetal growth and development, complete penetrance 1.98420713835831e-22 2.24350693484831e-20 0.712332945716838 0.878947368421053 15.1 15 1 abnormal motor capabilities/coordination/movement 5.50132245797687e-16 3.18245107307383e-14 0.712203689148934 0.878787878787879 15.1 15 1 abnormal angiogenesis 1.61784377864161e-09 3.67523872088677e-08 0.71187181417729 0.878378378378378 15.1 15 1 embryonic lethality during organogenesis, incomplete penetrance 9.73807472509612e-27 1.61489739191177e-24 0.711776580489774 0.878260869565217 15.1 15 1 liver fibrosis 8.32550033048556e-06 9.1433474931933e-05 0.711604695297673 0.878048780487805 15.1 15 1 palatal shelves fail to meet at midline 8.32550033048556e-06 9.1433474931933e-05 0.711604695297673 0.878048780487805 15.1 15 1 lethality at weaning, incomplete penetrance 8.32550033048556e-06 9.1433474931933e-05 0.711604695297673 0.878048780487805 15.1 15 1 reduced fertility 1.20458695392918e-16 7.68310268692009e-15 0.711320280951032 0.877697841726619 15.1 15 1 absent vitelline blood vessels 1.44135142710805e-07 2.32815693177355e-06 0.710911123469898 0.87719298245614 15.1 15 1 abnormal craniofacial bone morphology 1.44135142710805e-07 2.32815693177355e-06 0.710911123469898 0.87719298245614 15.1 15 1 decreased grip strength 2.88644781913926e-25 4.10287940006224e-23 0.710521583128271 0.876712328767123 15.1 15 1 astrocytosis 2.5836179584944e-09 5.61288180939285e-08 0.710521583128271 0.876712328767123 15.1 15 1 abnormal vertebral body morphology 0.000103643930154322 0.000860815613552174 0.709133845661223 0.875 15.1 15 1 abnormal spongiotrophoblast layer morphology 0.000103643930154322 0.000860815613552174 0.709133845661223 0.875 15.1 15 1 abnormal foregut morphology 0.00082908984208298 0.00513025119945625 0.709133845661223 0.875 15.1 15 1 abnormal osteoblast morphology 0.00082908984208298 0.00513025119945625 0.709133845661223 0.875 15.1 15 1 increased body temperature 0.00082908984208298 0.00513025119945625 0.709133845661223 0.875 15.1 15 1 abnormal lung saccule morphology 0.00082908984208298 0.00513025119945625 0.709133845661223 0.875 15.1 15 1 abnormal hair follicle orientation 0.00695478050480494 0.0310036138095023 0.709133845661223 0.875 15.1 15 1 disorganized retinal layers 0.00695478050480494 0.0310036138095023 0.709133845661223 0.875 15.1 15 1 disorganized yolk sac vascular plexus 0.00695478050480494 0.0310036138095023 0.709133845661223 0.875 15.1 15 1 abnormal epicardium morphology 0.00695478050480494 0.0310036138095023 0.709133845661223 0.875 15.1 15 1 paternal imprinting 0.00695478050480494 0.0310036138095023 0.709133845661223 0.875 15.1 15 1 decreased cochlear coiling 0.00695478050480494 0.0310036138095023 0.709133845661223 0.875 15.1 15 1 decreased aggression towards mice 0.00695478050480494 0.0310036138095023 0.709133845661223 0.875 15.1 15 1 small pancreas 0.00695478050480494 0.0310036138095023 0.709133845661223 0.875 15.1 15 1 dystonia 0.00695478050480494 0.0310036138095023 0.709133845661223 0.875 15.1 15 1 loose skin 0.00695478050480494 0.0310036138095023 0.709133845661223 0.875 15.1 15 1 kidney degeneration 0.00695478050480494 0.0310036138095023 0.709133845661223 0.875 15.1 15 1 impaired behavioral response to addictive substance 0.00695478050480494 0.0310036138095023 0.709133845661223 0.875 15.1 15 1 abnormal thoracic cage shape 0.00695478050480494 0.0310036138095023 0.709133845661223 0.875 15.1 15 1 decreased skeletal muscle weight 0.00695478050480494 0.0310036138095023 0.709133845661223 0.875 15.1 15 1 embryonic lethality between somite formation and embryo turning, incomplete penetrance 0.00695478050480494 0.0310036138095023 0.709133845661223 0.875 15.1 15 1 failure of vascular branching 0.064816380578698 0.173646469240184 0.709133845661223 0.875 15.1 15 1 schistocytosis 0.064816380578698 0.173646469240184 0.709133845661223 0.875 15.1 15 1 pointed snout 0.064816380578698 0.173646469240184 0.709133845661223 0.875 15.1 15 1 clubfoot 0.064816380578698 0.173646469240184 0.709133845661223 0.875 15.1 15 1 absent mammary gland 0.064816380578698 0.173646469240184 0.709133845661223 0.875 15.1 15 1 abnormal vagus ganglion morphology 0.064816380578698 0.173646469240184 0.709133845661223 0.875 15.1 15 1 dermal cysts 0.064816380578698 0.173646469240184 0.709133845661223 0.875 15.1 15 1 spinning 0.064816380578698 0.173646469240184 0.709133845661223 0.875 15.1 15 1 poor grooming 0.064816380578698 0.173646469240184 0.709133845661223 0.875 15.1 15 1 abnormal erythrocyte cell number 0.064816380578698 0.173646469240184 0.709133845661223 0.875 15.1 15 1 abnormal urination 0.064816380578698 0.173646469240184 0.709133845661223 0.875 15.1 15 1 preneoplasia 0.064816380578698 0.173646469240184 0.709133845661223 0.875 15.1 15 1 abnormal muscle precursor cell migration 0.064816380578698 0.173646469240184 0.709133845661223 0.875 15.1 15 1 hypospadia 0.064816380578698 0.173646469240184 0.709133845661223 0.875 15.1 15 1 absent tympanic ring 0.064816380578698 0.173646469240184 0.709133845661223 0.875 15.1 15 1 calcified muscle 0.064816380578698 0.173646469240184 0.709133845661223 0.875 15.1 15 1 increased cardiac output 0.064816380578698 0.173646469240184 0.709133845661223 0.875 15.1 15 1 abnormal ovary development 0.064816380578698 0.173646469240184 0.709133845661223 0.875 15.1 15 1 binucleate 0.064816380578698 0.173646469240184 0.709133845661223 0.875 15.1 15 1 abnormal forelimb zeugopod morphology 0.064816380578698 0.173646469240184 0.709133845661223 0.875 15.1 15 1 lymph node inflammation 0.064816380578698 0.173646469240184 0.709133845661223 0.875 15.1 15 1 abnormal extraembryonic tissue physiology 0.064816380578698 0.173646469240184 0.709133845661223 0.875 15.1 15 1 long femur 0.064816380578698 0.173646469240184 0.709133845661223 0.875 15.1 15 1 bowed fibula 0.064816380578698 0.173646469240184 0.709133845661223 0.875 15.1 15 1 small frontal bone 0.064816380578698 0.173646469240184 0.709133845661223 0.875 15.1 15 1 abnormal kidney epithelium morphology 0.064816380578698 0.173646469240184 0.709133845661223 0.875 15.1 15 1 abnormal NK cell morphology 0.064816380578698 0.173646469240184 0.709133845661223 0.875 15.1 15 1 abnormal choroid pigmentation 0.064816380578698 0.173646469240184 0.709133845661223 0.875 15.1 15 1 non-pigmented tail tip 0.064816380578698 0.173646469240184 0.709133845661223 0.875 15.1 15 1 abnormal vertebral body development 0.064816380578698 0.173646469240184 0.709133845661223 0.875 15.1 15 1 Sertoli cell hypoplasia 0.064816380578698 0.173646469240184 0.709133845661223 0.875 15.1 15 1 ocular hypertension 0.064816380578698 0.173646469240184 0.709133845661223 0.875 15.1 15 1 stomach epithelial hyperplasia 0.064816380578698 0.173646469240184 0.709133845661223 0.875 15.1 15 1 choroidal neovascularization 0.064816380578698 0.173646469240184 0.709133845661223 0.875 15.1 15 1 absent outer ear 0.064816380578698 0.173646469240184 0.709133845661223 0.875 15.1 15 1 abnormal epidermal lamellar body morphology 0.064816380578698 0.173646469240184 0.709133845661223 0.875 15.1 15 1 abnormal sphingomyelin level 0.064816380578698 0.173646469240184 0.709133845661223 0.875 15.1 15 1 abnormal frontonasal prominence morphology 0.064816380578698 0.173646469240184 0.709133845661223 0.875 15.1 15 1 decreased hippocampus pyramidal cell number 0.064816380578698 0.173646469240184 0.709133845661223 0.875 15.1 15 1 abnormal hepatic vein morphology 0.064816380578698 0.173646469240184 0.709133845661223 0.875 15.1 15 1 anomalous pulmonary venous connection 0.064816380578698 0.173646469240184 0.709133845661223 0.875 15.1 15 1 pulmonary artery hypoplasia 0.064816380578698 0.173646469240184 0.709133845661223 0.875 15.1 15 1 increased heart right ventricle size 0.064816380578698 0.173646469240184 0.709133845661223 0.875 15.1 15 1 delayed suture closure 0.064816380578698 0.173646469240184 0.709133845661223 0.875 15.1 15 1 decreased alveolar lamellar body number 0.064816380578698 0.173646469240184 0.709133845661223 0.875 15.1 15 1 abnormal bronchiole epithelium morphology 0.064816380578698 0.173646469240184 0.709133845661223 0.875 15.1 15 1 abnormal bronchus epithelium morphology 0.064816380578698 0.173646469240184 0.709133845661223 0.875 15.1 15 1 lethality during fetal growth through weaning, incomplete penetrance 0.064816380578698 0.173646469240184 0.709133845661223 0.875 15.1 15 1 decreased cranium length 0.064816380578698 0.173646469240184 0.709133845661223 0.875 15.1 15 1 prolonged PQ interval 0.064816380578698 0.173646469240184 0.709133845661223 0.875 15.1 15 1 increased cornea thickness 0.064816380578698 0.173646469240184 0.709133845661223 0.875 15.1 15 1 increased testis apoptosis 0.064816380578698 0.173646469240184 0.709133845661223 0.875 15.1 15 1 decreased white adipose tissue mass 0.064816380578698 0.173646469240184 0.709133845661223 0.875 15.1 15 1 decreased basal metabolism 0.064816380578698 0.173646469240184 0.709133845661223 0.875 15.1 15 1 impaired righting response 1.62660971041643e-11 5.18742519828316e-10 0.708067478976018 0.873684210526316 15.1 15 1 abnormal skeletal muscle fiber morphology 6.55256578712983e-09 1.34152324242679e-07 0.707707016997921 0.873239436619718 15.1 15 1 increased circulating aspartate transaminase level 4.88194117912827e-08 8.83187540587751e-07 0.707525832405756 0.873015873015873 15.1 15 1 abnormal embryo turning 3.66127204557715e-07 5.38900249312021e-06 0.707291939568597 0.872727272727273 15.1 15 1 decreased circulating total protein level 3.66127204557715e-07 5.38900249312021e-06 0.707291939568597 0.872727272727273 15.1 15 1 increased respiratory quotient 2.77002735149305e-06 3.4280811128552e-05 0.706978423637937 0.872340425531915 15.1 15 1 decreased bone trabecula number 2.77002735149305e-06 3.4280811128552e-05 0.706978423637937 0.872340425531915 15.1 15 1 increased circulating alanine transaminase level 1.40374370386381e-09 3.21826033489514e-08 0.706536285787006 0.871794871794872 15.1 15 1 abnormal heart ventricle morphology 1.40374370386381e-09 3.21826033489514e-08 0.706536285787006 0.871794871794872 15.1 15 1 abnormal heart looping 2.12131532893245e-05 0.000209812003209521 0.706536285787006 0.871794871794872 15.1 15 1 failure of heart looping 2.12131532893245e-05 0.000209812003209521 0.706536285787006 0.871794871794872 15.1 15 1 decreased startle reflex 1.04212916088704e-13 4.7132659776482e-12 0.706536285787006 0.871794871794872 15.1 15 1 insulin resistance 3.10171739169046e-15 1.65925204555484e-13 0.706064002173512 0.871212121212121 15.1 15 1 abnormal nose morphology 0.000165342202676681 0.00127928065056996 0.70586594775495 0.870967741935484 15.1 15 1 small cranium 0.000165342202676681 0.00127928065056996 0.70586594775495 0.870967741935484 15.1 15 1 increased anxiety-related response 6.74343306625197e-16 3.81253748012717e-14 0.705489786844876 0.870503597122302 15.1 15 1 abnormal mandible morphology 5.8141334118569e-07 8.24083012079432e-06 0.705381814731799 0.87037037037037 15.1 15 1 abnormal apoptosis 5.8141334118569e-07 8.24083012079432e-06 0.705381814731799 0.87037037037037 15.1 15 1 neurodegeneration 5.8141334118569e-07 8.24083012079432e-06 0.705381814731799 0.87037037037037 15.1 15 1 increased circulating alkaline phosphatase level 2.77280911066885e-18 2.12226543470423e-16 0.705381814731799 0.87037037037037 15.1 15 1 enlarged liver 8.84078203231843e-12 2.95187185307276e-10 0.705081652257445 0.87 15.1 15 1 abnormal innervation pattern to muscle 0.00132481948565623 0.00775409051898793 0.704729287613638 0.869565217391304 15.1 15 1 abnormal cochlear ganglion morphology 0.00132481948565623 0.00775409051898793 0.704729287613638 0.869565217391304 15.1 15 1 dilated heart 0.00132481948565623 0.00775409051898793 0.704729287613638 0.869565217391304 15.1 15 1 abnormal vertebral artery topology 0.00132481948565623 0.00775409051898793 0.704729287613638 0.869565217391304 15.1 15 1 hydroencephaly 2.61389707530633e-13 1.09278470165118e-11 0.704729287613638 0.869565217391304 15.1 15 1 perimembraneous ventricular septal defect 1.64907261600543e-08 3.19227092008833e-07 0.704729287613638 0.869565217391304 15.1 15 1 increased grooming behavior 3.36933581059634e-05 0.000310991570644096 0.703802012235199 0.868421052631579 15.1 15 1 decreased neuron apoptosis 3.36933581059634e-05 0.000310991570644096 0.703802012235199 0.868421052631579 15.1 15 1 impaired branching involved in ureteric bud morphogenesis 3.36933581059634e-05 0.000310991570644096 0.703802012235199 0.868421052631579 15.1 15 1 respiratory distress 5.18121637224545e-19 4.35850167266864e-17 0.702692497765044 0.867052023121387 15.1 15 1 thin ventricular wall 1.61867052404482e-10 4.26078616778994e-09 0.702380189988259 0.866666666666667 15.1 15 1 oxidative stress 1.61867052404482e-10 4.26078616778994e-09 0.702380189988259 0.866666666666667 15.1 15 1 delayed bone ossification 5.56047349964081e-09 1.14484025106538e-07 0.702380189988259 0.866666666666667 15.1 15 1 abnormal kidney development 1.94169957671041e-07 2.99069826443786e-06 0.702380189988259 0.866666666666667 15.1 15 1 absent mesoderm 1.94169957671041e-07 2.99069826443786e-06 0.702380189988259 0.866666666666667 15.1 15 1 intracranial hemorrhage 1.94169957671041e-07 2.99069826443786e-06 0.702380189988259 0.866666666666667 15.1 15 1 abnormal ovarian follicle morphology 6.96567142440088e-06 7.73531592330232e-05 0.702380189988259 0.866666666666667 15.1 15 1 irregular heartbeat 6.96567142440088e-06 7.73531592330232e-05 0.702380189988259 0.866666666666667 15.1 15 1 small placenta 6.96567142440088e-06 7.73531592330232e-05 0.702380189988259 0.866666666666667 15.1 15 1 abnormal metabolism 6.96567142440088e-06 7.73531592330232e-05 0.702380189988259 0.866666666666667 15.1 15 1 cardiomyopathy 6.96567142440088e-06 7.73531592330232e-05 0.702380189988259 0.866666666666667 15.1 15 1 emphysema 0.000262676271320243 0.00190497733209651 0.702380189988259 0.866666666666667 15.1 15 1 disorganized myocardium 0.000262676271320243 0.00190497733209651 0.702380189988259 0.866666666666667 15.1 15 1 liver hemorrhage 0.000262676271320243 0.00190497733209651 0.702380189988259 0.866666666666667 15.1 15 1 absent incisors 0.0111470685163918 0.044507757519301 0.702380189988259 0.866666666666667 15.1 15 1 no suckling reflex 0.0111470685163918 0.044507757519301 0.702380189988259 0.866666666666667 15.1 15 1 absent egg cylinders 0.0111470685163918 0.044507757519301 0.702380189988259 0.866666666666667 15.1 15 1 increased airway responsiveness 0.0111470685163918 0.044507757519301 0.702380189988259 0.866666666666667 15.1 15 1 abnormal bronchus morphology 0.0111470685163918 0.044507757519301 0.702380189988259 0.866666666666667 15.1 15 1 abnormal lymph node B cell domain morphology 0.0111470685163918 0.044507757519301 0.702380189988259 0.866666666666667 15.1 15 1 abnormal pericyte morphology 0.0111470685163918 0.044507757519301 0.702380189988259 0.866666666666667 15.1 15 1 decreased aggression towards males 0.0111470685163918 0.044507757519301 0.702380189988259 0.866666666666667 15.1 15 1 abnormal placenta size 0.0111470685163918 0.044507757519301 0.702380189988259 0.866666666666667 15.1 15 1 abnormal trophectoderm morphology 0.0111470685163918 0.044507757519301 0.702380189988259 0.866666666666667 15.1 15 1 abnormal energy homeostasis 0.0111470685163918 0.044507757519301 0.702380189988259 0.866666666666667 15.1 15 1 ostium primum atrial septal defect 0.0111470685163918 0.044507757519301 0.702380189988259 0.866666666666667 15.1 15 1 abnormal microglial cell activation 0.0111470685163918 0.044507757519301 0.702380189988259 0.866666666666667 15.1 15 1 decreased trabecular bone mass 0.0111470685163918 0.044507757519301 0.702380189988259 0.866666666666667 15.1 15 1 herniated liver 0.0111470685163918 0.044507757519301 0.702380189988259 0.866666666666667 15.1 15 1 abnormal branching involved in lung morphogenesis 0.0111470685163918 0.044507757519301 0.702380189988259 0.866666666666667 15.1 15 1 decreased brown adipose tissue mass 0.0111470685163918 0.044507757519301 0.702380189988259 0.866666666666667 15.1 15 1 abnormal myocardial fiber morphology 3.48210000259978e-11 1.07599052875366e-09 0.70182318745853 0.865979381443299 15.1 15 1 abnormal cranium morphology 6.62056772822969e-15 3.29373244479427e-13 0.701573783340741 0.865671641791045 15.1 15 1 decreased white adipose tissue amount 4.11636438789434e-08 7.55679440213075e-07 0.701573783340741 0.865671641791045 15.1 15 1 abnormal skin condition 1.45490672058052e-06 1.88493774346043e-05 0.701341166038572 0.865384615384615 15.1 15 1 decreased hemoglobin content 1.435383374579e-15 7.93448032058949e-14 0.70123063157584 0.865248226950355 15.1 15 1 pale liver 8.76457270955214e-09 1.75821569475895e-07 0.700919940113024 0.864864864864865 15.1 15 1 malocclusion 5.33265735585742e-05 0.000464622948255528 0.700919940113024 0.864864864864865 15.1 15 1 abnormal long bone metaphysis morphology 5.33265735585742e-05 0.000464622948255528 0.700919940113024 0.864864864864865 15.1 15 1 increased erythroid progenitor cell number 5.33265735585742e-05 0.000464622948255528 0.700919940113024 0.864864864864865 15.1 15 1 abnormal calcium ion homeostasis 5.33265735585742e-05 0.000464622948255528 0.700919940113024 0.864864864864865 15.1 15 1 abnormal humerus morphology 5.33265735585742e-05 0.000464622948255528 0.700919940113024 0.864864864864865 15.1 15 1 abnormal respiratory electron transport chain 5.33265735585742e-05 0.000464622948255528 0.700919940113024 0.864864864864865 15.1 15 1 increased susceptibility to pharmacologically induced seizures 5.48246266836388e-11 1.60442657500649e-09 0.700691776070018 0.864583333333333 15.1 15 1 abnormal thoracic vertebrae morphology 3.06210653345848e-07 4.54745671759879e-06 0.700548690144744 0.864406779661017 15.1 15 1 increased hemoglobin content 3.06210653345848e-07 4.54745671759879e-06 0.700548690144744 0.864406779661017 15.1 15 1 abnormal embryonic tissue morphology 4.89589412378585e-16 2.86553803127466e-14 0.700174914666475 0.863945578231292 15.1 15 1 osteoporosis 1.09955319282523e-05 0.000116637039110992 0.699924315198091 0.863636363636364 15.1 15 1 lethality, incomplete penetrance 1.09955319282523e-05 0.000116637039110992 0.699924315198091 0.863636363636364 15.1 15 1 embryonic lethality, incomplete penetrance 1.09955319282523e-05 0.000116637039110992 0.699924315198091 0.863636363636364 15.1 15 1 abnormal basisphenoid bone morphology 0.00210550642530493 0.0113364658721775 0.699924315198091 0.863636363636364 15.1 15 1 abnormal facial nerve morphology 0.00210550642530493 0.0113364658721775 0.699924315198091 0.863636363636364 15.1 15 1 aphakia 0.00210550642530493 0.0113364658721775 0.699924315198091 0.863636363636364 15.1 15 1 abnormal cochlear sensory epithelium morphology 0.00210550642530493 0.0113364658721775 0.699924315198091 0.863636363636364 15.1 15 1 decreased cardiac output 0.00210550642530493 0.0113364658721775 0.699924315198091 0.863636363636364 15.1 15 1 cleft upper lip 0.00210550642530493 0.0113364658721775 0.699924315198091 0.863636363636364 15.1 15 1 abnormal temporal bone morphology 0.00210550642530493 0.0113364658721775 0.699924315198091 0.863636363636364 15.1 15 1 pulmonary vascular congestion 0.00210550642530493 0.0113364658721775 0.699924315198091 0.863636363636364 15.1 15 1 increased bone volume 0.00210550642530493 0.0113364658721775 0.699924315198091 0.863636363636364 15.1 15 1 abnormal vascular development 6.48262015869533e-08 1.13961255439962e-06 0.69992431519809 0.863636363636364 15.1 15 1 prenatal lethality, complete penetrance 5.88998533376286e-29 1.04652417983822e-26 0.69965929273872 0.863309352517986 15.1 15 1 increased heart weight 3.54807595856844e-15 1.83871644727896e-13 0.69965929273872 0.863309352517986 15.1 15 1 impaired glucose tolerance 6.55551365487324e-26 9.88293346454374e-24 0.699330151942404 0.862903225806452 15.1 15 1 increased tumor incidence 1.18857146406366e-13 5.32715588623125e-12 0.699330151942404 0.862903225806452 15.1 15 1 abnormal gluconeogenesis 2.29216284708146e-06 2.87242069627967e-05 0.699201999083335 0.862745098039216 15.1 15 1 abnormal parietal bone morphology 0.000415466780570015 0.00281600440508968 0.69865403513421 0.862068965517241 15.1 15 1 lordosis 0.000415466780570015 0.00281600440508968 0.69865403513421 0.862068965517241 15.1 15 1 increased mortality induced by gamma-irradiation 0.000415466780570015 0.00281600440508968 0.69865403513421 0.862068965517241 15.1 15 1 abnormal outer ear morphology 0.000415466780570015 0.00281600440508968 0.69865403513421 0.862068965517241 15.1 15 1 decreased bone strength 0.000415466780570015 0.00281600440508968 0.69865403513421 0.862068965517241 15.1 15 1 decreased anxiety-related response 1.86465354485952e-13 7.99711326351388e-12 0.698426830569939 0.861788617886179 15.1 15 1 increased or absent threshold for auditory brainstem response 1.0735446111326e-29 2.13635377615387e-27 0.698267237052475 0.86159169550173 15.1 15 1 decreased body length 3.58222206629574e-28 6.14536371717976e-26 0.698042075395406 0.861313868613139 15.1 15 1 short snout 6.26825122100577e-12 2.12139794724515e-10 0.69787775287295 0.861111111111111 15.1 15 1 renal hypoplasia 8.40853222064484e-05 0.000704249962924378 0.69787775287295 0.861111111111111 15.1 15 1 respiratory failure 4.09954387424148e-16 2.42800366361326e-14 0.697728665551251 0.860927152317881 15.1 15 1 decreased body size 1.08870893626581e-79 1.08326539158448e-76 0.697708488319743 0.860902255639098 15.1 15 1 abnormal skeleton morphology 1.35244878380839e-12 4.98402422181241e-11 0.697681994737501 0.860869565217391 15.1 15 1 abnormal myocardium layer morphology 4.61699610681235e-09 9.77427899208148e-08 0.697592788498563 0.860759493670886 15.1 15 1 increased circulating creatinine level 9.87952460905964e-10 2.36301129471499e-08 0.697354213673495 0.86046511627907 15.1 15 1 decreased heart rate 4.55674077478073e-11 1.34140741742806e-09 0.696977265449888 0.86 15.1 15 1 decreased respiratory quotient 3.60095001153302e-06 4.33770612769413e-05 0.696977265449888 0.86 15.1 15 1 decreased birth body size 2.116856906838e-12 7.63142254457902e-11 0.6966929010005 0.859649122807018 15.1 15 1 decreased circulating LDL cholesterol level 1.5969002722954e-07 2.5382041069232e-06 0.696470741274416 0.859375 15.1 15 1 decreased caudal vertebrae number 1.5969002722954e-07 2.5382041069232e-06 0.696470741274416 0.859375 15.1 15 1 abnormal osteoclast physiology 1.5969002722954e-07 2.5382041069232e-06 0.696470741274416 0.859375 15.1 15 1 increased circulating free fatty acid level 3.39073849670164e-08 6.36563170607195e-07 0.696292387691503 0.859154929577465 15.1 15 1 decreased circulating serum albumin level 7.12579708854072e-11 2.04918153268729e-09 0.695831190547809 0.858585858585859 15.1 15 1 perinatal lethality, incomplete penetrance 5.05122857888462e-23 6.28246554498775e-21 0.695686301179658 0.858407079646018 15.1 15 1 premature death 2.1621599596581e-84 2.68918644982476e-81 0.695603002413996 0.858304297328688 15.1 15 1 postnatal lethality, complete penetrance 4.11485438706488e-38 1.36476003837652e-35 0.694961666658371 0.857512953367876 15.1 15 1 cardiac hypertrophy 1.11254581323978e-10 3.07178559085981e-09 0.694661726362015 0.857142857142857 15.1 15 1 organ of Corti degeneration 5.64026946550306e-06 6.54087193260553e-05 0.694661726362015 0.857142857142857 15.1 15 1 abnormal optic nerve morphology 2.71295512018126e-05 0.000257084794721938 0.694661726362015 0.857142857142857 15.1 15 1 skin edema 2.71295512018126e-05 0.000257084794721938 0.694661726362015 0.857142857142857 15.1 15 1 abnormal pancreas morphology 2.71295512018126e-05 0.000257084794721938 0.694661726362015 0.857142857142857 15.1 15 1 shortened head 0.000654032150725352 0.00419305405909617 0.694661726362015 0.857142857142857 15.1 15 1 abnormal ovulation 0.000654032150725352 0.00419305405909617 0.694661726362015 0.857142857142857 15.1 15 1 abnormal respiration 0.000654032150725352 0.00419305405909617 0.694661726362015 0.857142857142857 15.1 15 1 enhanced coordination 0.000654032150725352 0.00419305405909617 0.694661726362015 0.857142857142857 15.1 15 1 small ears 0.00332653916600869 0.0166998308283484 0.694661726362015 0.857142857142857 15.1 15 1 abnormal eye pigmentation 0.00332653916600869 0.0166998308283484 0.694661726362015 0.857142857142857 15.1 15 1 trunk curl 0.00332653916600869 0.0166998308283484 0.694661726362015 0.857142857142857 15.1 15 1 abnormal stapes morphology 0.00332653916600869 0.0166998308283484 0.694661726362015 0.857142857142857 15.1 15 1 embryonic lethality at implantation, complete penetrance 0.00332653916600869 0.0166998308283484 0.694661726362015 0.857142857142857 15.1 15 1 decreased vocalization 0.00332653916600869 0.0166998308283484 0.694661726362015 0.857142857142857 15.1 15 1 abnormal interparietal bone morphology 0.0177262697140268 0.0651316040083333 0.694661726362015 0.857142857142857 15.1 15 1 absent atrioventricular cushions 0.0177262697140268 0.0651316040083333 0.694661726362015 0.857142857142857 15.1 15 1 irregularly shaped pupil 0.0177262697140268 0.0651316040083333 0.694661726362015 0.857142857142857 15.1 15 1 abnormal pinna reflex 0.0177262697140268 0.0651316040083333 0.694661726362015 0.857142857142857 15.1 15 1 extended life span 0.0177262697140268 0.0651316040083333 0.694661726362015 0.857142857142857 15.1 15 1 abnormal fluid regulation 0.0177262697140268 0.0651316040083333 0.694661726362015 0.857142857142857 15.1 15 1 abnormal endplate potential 0.0177262697140268 0.0651316040083333 0.694661726362015 0.857142857142857 15.1 15 1 increased lactate dehydrogenase level 0.0177262697140268 0.0651316040083333 0.694661726362015 0.857142857142857 15.1 15 1 decreased vascular permeability 0.0177262697140268 0.0651316040083333 0.694661726362015 0.857142857142857 15.1 15 1 abnormal ventral body wall morphology 0.0177262697140268 0.0651316040083333 0.694661726362015 0.857142857142857 15.1 15 1 abnormal vascular endothelial cell migration 0.0177262697140268 0.0651316040083333 0.694661726362015 0.857142857142857 15.1 15 1 vascular smooth muscle hypoplasia 0.0177262697140268 0.0651316040083333 0.694661726362015 0.857142857142857 15.1 15 1 abnormal maternal decidual layer morphology 0.0177262697140268 0.0651316040083333 0.694661726362015 0.857142857142857 15.1 15 1 increased circulating growth hormone level 0.0177262697140268 0.0651316040083333 0.694661726362015 0.857142857142857 15.1 15 1 decreased tongue size 0.0177262697140268 0.0651316040083333 0.694661726362015 0.857142857142857 15.1 15 1 sternebra fusion 0.0177262697140268 0.0651316040083333 0.694661726362015 0.857142857142857 15.1 15 1 increased stomach tumor incidence 0.0177262697140268 0.0651316040083333 0.694661726362015 0.857142857142857 15.1 15 1 decreased response to antigen 0.0177262697140268 0.0651316040083333 0.694661726362015 0.857142857142857 15.1 15 1 cochlear degeneration 0.10465002048399 0.237623848428959 0.694661726362015 0.857142857142857 15.1 15 1 absent endolymphatic duct 0.10465002048399 0.237623848428959 0.694661726362015 0.857142857142857 15.1 15 1 asymmetric rib joints 0.10465002048399 0.237623848428959 0.694661726362015 0.857142857142857 15.1 15 1 cellular necrosis 0.10465002048399 0.237623848428959 0.694661726362015 0.857142857142857 15.1 15 1 abnormal foot pad morphology 0.10465002048399 0.237623848428959 0.694661726362015 0.857142857142857 15.1 15 1 mammary gland hyperplasia 0.10465002048399 0.237623848428959 0.694661726362015 0.857142857142857 15.1 15 1 small L4 dorsal root ganglion 0.10465002048399 0.237623848428959 0.694661726362015 0.857142857142857 15.1 15 1 abnormal oculomotor nerve morphology 0.10465002048399 0.237623848428959 0.694661726362015 0.857142857142857 15.1 15 1 skin photosensitivity 0.10465002048399 0.237623848428959 0.694661726362015 0.857142857142857 15.1 15 1 retina hyperplasia 0.10465002048399 0.237623848428959 0.694661726362015 0.857142857142857 15.1 15 1 abnormal lacrimal gland morphology 0.10465002048399 0.237623848428959 0.694661726362015 0.857142857142857 15.1 15 1 limp posture 0.10465002048399 0.237623848428959 0.694661726362015 0.857142857142857 15.1 15 1 abnormal axial mesoderm 0.10465002048399 0.237623848428959 0.694661726362015 0.857142857142857 15.1 15 1 absent amniotic folds 0.10465002048399 0.237623848428959 0.694661726362015 0.857142857142857 15.1 15 1 increased chemically-elicited antinociception 0.10465002048399 0.237623848428959 0.694661726362015 0.857142857142857 15.1 15 1 abnormal gastrulation movements 0.10465002048399 0.237623848428959 0.694661726362015 0.857142857142857 15.1 15 1 abnormal brain ventricular system morphology 0.10465002048399 0.237623848428959 0.694661726362015 0.857142857142857 15.1 15 1 increased retinal ganglion cell number 0.10465002048399 0.237623848428959 0.694661726362015 0.857142857142857 15.1 15 1 decreased urine calcium level 0.10465002048399 0.237623848428959 0.694661726362015 0.857142857142857 15.1 15 1 abnormal superior semicircular canal morphology 0.10465002048399 0.237623848428959 0.694661726362015 0.857142857142857 15.1 15 1 detached tectorial membrane 0.10465002048399 0.237623848428959 0.694661726362015 0.857142857142857 15.1 15 1 abnormal neurotransmitter uptake 0.10465002048399 0.237623848428959 0.694661726362015 0.857142857142857 15.1 15 1 skeletal muscle interstitial fibrosis 0.10465002048399 0.237623848428959 0.694661726362015 0.857142857142857 15.1 15 1 abnormal nephron morphology 0.10465002048399 0.237623848428959 0.694661726362015 0.857142857142857 15.1 15 1 increased ectoderm apoptosis 0.10465002048399 0.237623848428959 0.694661726362015 0.857142857142857 15.1 15 1 renal necrosis 0.10465002048399 0.237623848428959 0.694661726362015 0.857142857142857 15.1 15 1 abnormal organ of Corti supporting cell morphology 0.10465002048399 0.237623848428959 0.694661726362015 0.857142857142857 15.1 15 1 absent vestibular saccule 0.10465002048399 0.237623848428959 0.694661726362015 0.857142857142857 15.1 15 1 abnormal vestibular saccular macula morphology 0.10465002048399 0.237623848428959 0.694661726362015 0.857142857142857 15.1 15 1 absent ulna 0.10465002048399 0.237623848428959 0.694661726362015 0.857142857142857 15.1 15 1 abnormal strial marginal cell morphology 0.10465002048399 0.237623848428959 0.694661726362015 0.857142857142857 15.1 15 1 absent endocochlear potential 0.10465002048399 0.237623848428959 0.694661726362015 0.857142857142857 15.1 15 1 abnormal negative T cell selection 0.10465002048399 0.237623848428959 0.694661726362015 0.857142857142857 15.1 15 1 abnormal MHC II cell surface expression on macrophages 0.10465002048399 0.237623848428959 0.694661726362015 0.857142857142857 15.1 15 1 abnormal gallbladder morphology 0.10465002048399 0.237623848428959 0.694661726362015 0.857142857142857 15.1 15 1 abnormal talus morphology 0.10465002048399 0.237623848428959 0.694661726362015 0.857142857142857 15.1 15 1 atherosclerotic lesions 0.10465002048399 0.237623848428959 0.694661726362015 0.857142857142857 15.1 15 1 increased chronic myelocytic leukemia incidence 0.10465002048399 0.237623848428959 0.694661726362015 0.857142857142857 15.1 15 1 abnormal renal/urinary system physiology 0.10465002048399 0.237623848428959 0.694661726362015 0.857142857142857 15.1 15 1 abnormal body temperature 0.10465002048399 0.237623848428959 0.694661726362015 0.857142857142857 15.1 15 1 abnormal renal filtration rate 0.10465002048399 0.237623848428959 0.694661726362015 0.857142857142857 15.1 15 1 decreased tidal volume 0.10465002048399 0.237623848428959 0.694661726362015 0.857142857142857 15.1 15 1 increased keratinocyte apoptosis 0.10465002048399 0.237623848428959 0.694661726362015 0.857142857142857 15.1 15 1 uremia 0.10465002048399 0.237623848428959 0.694661726362015 0.857142857142857 15.1 15 1 abnormal spinal cord central canal morphology 0.10465002048399 0.237623848428959 0.694661726362015 0.857142857142857 15.1 15 1 enhanced behavioral response to alcohol 0.10465002048399 0.237623848428959 0.694661726362015 0.857142857142857 15.1 15 1 abnormal sperm annulus morphology 0.10465002048399 0.237623848428959 0.694661726362015 0.857142857142857 15.1 15 1 abnormal cerebellum white matter morphology 0.10465002048399 0.237623848428959 0.694661726362015 0.857142857142857 15.1 15 1 focal dorsal hair loss 0.10465002048399 0.237623848428959 0.694661726362015 0.857142857142857 15.1 15 1 abnormal retina inner limiting membrane morphology 0.10465002048399 0.237623848428959 0.694661726362015 0.857142857142857 15.1 15 1 long stride length 0.10465002048399 0.237623848428959 0.694661726362015 0.857142857142857 15.1 15 1 abnormal aortic valve cusp morphology 0.10465002048399 0.237623848428959 0.694661726362015 0.857142857142857 15.1 15 1 thick pulmonary valve 0.10465002048399 0.237623848428959 0.694661726362015 0.857142857142857 15.1 15 1 altered tumor pathology 0.10465002048399 0.237623848428959 0.694661726362015 0.857142857142857 15.1 15 1 abnormal impulsive behavior control 0.10465002048399 0.237623848428959 0.694661726362015 0.857142857142857 15.1 15 1 increased right ventricle systolic pressure 0.10465002048399 0.237623848428959 0.694661726362015 0.857142857142857 15.1 15 1 small lung saccule 0.10465002048399 0.237623848428959 0.694661726362015 0.857142857142857 15.1 15 1 increased compact bone volume 0.10465002048399 0.237623848428959 0.694661726362015 0.857142857142857 15.1 15 1 small lung lobe 0.10465002048399 0.237623848428959 0.694661726362015 0.857142857142857 15.1 15 1 embryonic lethality at implantation, incomplete penetrance 0.10465002048399 0.237623848428959 0.694661726362015 0.857142857142857 15.1 15 1 increased circulating lactate dehydrogenase level 0.10465002048399 0.237623848428959 0.694661726362015 0.857142857142857 15.1 15 1 impaired mammary gland growth during pregnancy 0.10465002048399 0.237623848428959 0.694661726362015 0.857142857142857 15.1 15 1 absent heart tube 0.10465002048399 0.237623848428959 0.694661726362015 0.857142857142857 15.1 15 1 dysmyelination 0.10465002048399 0.237623848428959 0.694661726362015 0.857142857142857 15.1 15 1 decreased areal bone mineral density 0.10465002048399 0.237623848428959 0.694661726362015 0.857142857142857 15.1 15 1 abnormal Mullerian duct topology 0.10465002048399 0.237623848428959 0.694661726362015 0.857142857142857 15.1 15 1 absent connection between subcutaneous lymph vessels and lymph sac 0.10465002048399 0.237623848428959 0.694661726362015 0.857142857142857 15.1 15 1 embryo tumor 0.10465002048399 0.237623848428959 0.694661726362015 0.857142857142857 15.1 15 1 thick pulmonary interalveolar septum 0.00013206379650674 0.00105122782019365 0.694661726362015 0.857142857142857 15.1 15 1 increased carcinoma incidence 0.00013206379650674 0.00105122782019365 0.694661726362015 0.857142857142857 15.1 15 1 holoprosencephaly 0.00013206379650674 0.00105122782019365 0.694661726362015 0.857142857142857 15.1 15 1 impaired behavioral response to xenobiotic 0.00013206379650674 0.00105122782019365 0.694661726362015 0.857142857142857 15.1 15 1 abnormal hippocampus pyramidal cell morphology 0.00013206379650674 0.00105122782019365 0.694661726362015 0.857142857142857 15.1 15 1 decreased bone volume 0.00013206379650674 0.00105122782019365 0.694661726362015 0.857142857142857 15.1 15 1 hemorrhage 2.19749753813312e-23 2.87698690847692e-21 0.693183722688904 0.85531914893617 15.1 15 1 abnormal blood vessel morphology 5.93428952028087e-15 2.9821303397371e-13 0.693064802853136 0.855172413793103 15.1 15 1 abnormal rostral-caudal axis patterning 1.84621939387503e-06 2.37336989264297e-05 0.692556690827584 0.854545454545454 15.1 15 1 cyanosis 3.2555480728829e-19 2.84146520396358e-17 0.692249706478813 0.854166666666667 15.1 15 1 decreased leukocyte cell number 4.25828126297516e-14 1.99858012106617e-12 0.692126464586971 0.854014598540146 15.1 15 1 abnormal muscle physiology 1.25597141824497e-09 2.9062594445436e-08 0.692059997049797 0.853932584269663 15.1 15 1 neonatal lethality, incomplete penetrance 1.83904726437557e-25 2.69095886478484e-23 0.691989950491391 0.853846153846154 15.1 15 1 decreased body weight 8.27430029322346e-118 2.05823219793934e-114 0.691949665233245 0.853796445880452 15.1 15 1 abnormal mammary gland development 4.23915675749476e-05 0.000378632044318428 0.691837898206071 0.853658536585366 15.1 15 1 decreased erythrocyte cell number 6.74378488947118e-16 3.81253748012717e-14 0.691711995039883 0.853503184713376 15.1 15 1 enlarged heart 8.26667335388891e-23 1.00309024233164e-20 0.691667494782868 0.853448275862069 15.1 15 1 abnormal neurocranium morphology 2.74066044763089e-08 5.18432917375044e-07 0.691574340911517 0.853333333333333 15.1 15 1 abnormal vertebrae morphology 1.94655297775418e-11 6.16821723842486e-10 0.691475204681455 0.853211009174312 15.1 15 1 increased insulin sensitivity 1.43328121159699e-14 6.92288740552916e-13 0.691423210155199 0.853146853146853 15.1 15 1 neonatal lethality, complete penetrance 2.07810340658713e-43 7.38468889126497e-41 0.691361067574476 0.853070175438597 15.1 15 1 postnatal growth retardation 7.54637541241561e-58 4.69290220959596e-55 0.691256521821024 0.852941176470588 15.1 15 1 abnormal brown adipose tissue morphology 0.000206555485711898 0.00155638013199055 0.691256521821024 0.852941176470588 15.1 15 1 abnormal bone remodeling 0.000206555485711898 0.00155638013199055 0.691256521821024 0.852941176470588 15.1 15 1 decreased circulating cholesterol level 3.61297866525546e-18 2.72341952418878e-16 0.690865760644189 0.852459016393443 15.1 15 1 abnormal long bone epiphyseal plate proliferative zone 2.87324840455979e-06 3.52948415128024e-05 0.690373691014101 0.851851851851852 15.1 15 1 decreased platelet aggregation 2.87324840455979e-06 3.52948415128024e-05 0.690373691014101 0.851851851851852 15.1 15 1 abnormal heart valve morphology 0.00102438802050675 0.00616243095770387 0.690373691014101 0.851851851851852 15.1 15 1 thin epidermis 0.00102438802050675 0.00616243095770387 0.690373691014101 0.851851851851852 15.1 15 1 increased brain weight 0.00102438802050675 0.00616243095770387 0.690373691014101 0.851851851851852 15.1 15 1 abnormal rib morphology 1.02562575974642e-13 4.68118179333802e-12 0.690373691014101 0.851851851851852 15.1 15 1 abnormal intestine morphology 4.25548150284127e-08 7.75495255554407e-07 0.689968066048758 0.851351351351351 15.1 15 1 cleft secondary palate 6.50143802257504e-10 1.5777880079176e-08 0.689735047451646 0.851063829787234 15.1 15 1 neuron degeneration 1.37082615962821e-05 0.000142974007214892 0.689735047451646 0.851063829787234 15.1 15 1 decreased bone mineral content 3.00456343650047e-20 3.05055165236527e-18 0.689652146604596 0.850961538461538 15.1 15 1 decreased total body fat amount 1.61942745441404e-31 3.50289199378689e-29 0.689115524953935 0.850299401197605 15.1 15 1 small gonad 0.00522188997944569 0.0239436890762602 0.688872878642331 0.85 15.1 15 1 abnormal hearing physiology 0.00522188997944569 0.0239436890762602 0.688872878642331 0.85 15.1 15 1 abnormal hyoid bone morphology 0.00522188997944569 0.0239436890762602 0.688872878642331 0.85 15.1 15 1 dilated vasculature 0.00522188997944569 0.0239436890762602 0.688872878642331 0.85 15.1 15 1 abnormal incus morphology 0.00522188997944569 0.0239436890762602 0.688872878642331 0.85 15.1 15 1 abnormal response to tactile stimuli 0.00522188997944569 0.0239436890762602 0.688872878642331 0.85 15.1 15 1 abnormal induced retinal neovascularization 0.00522188997944569 0.0239436890762602 0.688872878642331 0.85 15.1 15 1 abnormal sperm mitochondrial sheath morphology 0.00522188997944569 0.0239436890762602 0.688872878642331 0.85 15.1 15 1 abnormal heart electrocardiography waveform feature 0.00522188997944569 0.0239436890762602 0.688872878642331 0.85 15.1 15 1 decreased muscle cell glucose uptake 0.00522188997944569 0.0239436890762602 0.688872878642331 0.85 15.1 15 1 epidermal hyperplasia 9.41107928836407e-07 1.26540863404355e-05 0.688872878642331 0.85 15.1 15 1 abnormal long bone epiphyseal plate morphology 9.41107928836407e-07 1.26540863404355e-05 0.688872878642331 0.85 15.1 15 1 abnormal incisor morphology 9.41107928836407e-07 1.26540863404355e-05 0.688872878642331 0.85 15.1 15 1 abnormal definitive hematopoiesis 1.00644844318771e-09 2.39573253820999e-08 0.688437158921495 0.849462365591398 15.1 15 1 enlarged kidney 4.45844442686463e-06 5.21900259380036e-05 0.688108313849165 0.849056603773585 15.1 15 1 increased oxygen consumption 4.67999580164565e-09 9.86566911575725e-08 0.687930508083313 0.848837209302326 15.1 15 1 abnormal lung morphology 5.23208038861578e-12 1.79018564436707e-10 0.687851317280034 0.848739495798319 15.1 15 1 impaired swimming 3.09267439655866e-07 4.57918307228551e-06 0.687644941247247 0.848484848484849 15.1 15 1 abnormal tooth development 0.000321642065816472 0.00228269511759907 0.687644941247247 0.848484848484849 15.1 15 1 abnormal epidermis stratum basale morphology 0.000321642065816472 0.00228269511759907 0.687644941247247 0.848484848484849 15.1 15 1 abnormal skeleton physiology 0.000321642065816472 0.00228269511759907 0.687644941247247 0.848484848484849 15.1 15 1 hunched posture 2.18100018017613e-08 4.1572704583817e-07 0.687334071020643 0.848101265822785 15.1 15 1 abnormal visceral yolk sac morphology 2.18100018017613e-08 4.1572704583817e-07 0.687334071020643 0.848101265822785 15.1 15 1 abnormal allantois morphology 2.12649955484518e-05 0.000209907446137992 0.687111055423297 0.847826086956522 15.1 15 1 increased circulating HDL cholesterol level 1.11757425516709e-10 3.07178559085981e-09 0.68694326273577 0.847619047619048 15.1 15 1 cochlear outer hair cell degeneration 1.01910867640263e-07 1.72451213098744e-06 0.686621660084676 0.847222222222222 15.1 15 1 cardiac fibrosis 7.22747939540779e-09 1.46165487772983e-07 0.686489235463638 0.847058823529412 15.1 15 1 postnatal lethality, incomplete penetrance 1.98503904741394e-51 9.87556926088435e-49 0.686304587048387 0.846830985915493 15.1 15 1 abnormal locomotor activation 2.39865871930326e-09 5.25697230331882e-08 0.685755806793271 0.846153846153846 15.1 15 1 increased grip strength 2.39865871930326e-09 5.25697230331882e-08 0.685755806793271 0.846153846153846 15.1 15 1 decreased cardiac muscle contractility 1.72296210452732e-10 4.46444607813719e-09 0.685755806793271 0.846153846153846 15.1 15 1 increased rib number 3.3659740111486e-08 6.34307602479708e-07 0.685755806793271 0.846153846153846 15.1 15 1 abnormal snout morphology 6.89707154283667e-06 7.73531592330232e-05 0.685755806793271 0.846153846153846 15.1 15 1 eyelids open at birth 6.89707154283667e-06 7.73531592330232e-05 0.685755806793271 0.846153846153846 15.1 15 1 kinked neural tube 6.89707154283667e-06 7.73531592330232e-05 0.685755806793271 0.846153846153846 15.1 15 1 abnormal female meiosis 6.89707154283667e-06 7.73531592330232e-05 0.685755806793271 0.846153846153846 15.1 15 1 impaired macrophage chemotaxis 0.000102334484597476 0.000852787371645636 0.685755806793271 0.846153846153846 15.1 15 1 abnormal xiphoid process morphology 0.00159577656727114 0.00904212804347828 0.685755806793271 0.846153846153846 15.1 15 1 abnormal ureter morphology 0.00159577656727114 0.00904212804347828 0.685755806793271 0.846153846153846 15.1 15 1 no spontaneous movement 0.00159577656727114 0.00904212804347828 0.685755806793271 0.846153846153846 15.1 15 1 heart inflammation 0.00159577656727114 0.00904212804347828 0.685755806793271 0.846153846153846 15.1 15 1 increased leukemia incidence 0.00159577656727114 0.00904212804347828 0.685755806793271 0.846153846153846 15.1 15 1 short premaxilla 0.02793768543671 0.0930434385313076 0.685755806793271 0.846153846153846 15.1 15 1 absent common myeloid progenitor cells 0.02793768543671 0.0930434385313076 0.685755806793271 0.846153846153846 15.1 15 1 increased foot pad pigmentation 0.02793768543671 0.0930434385313076 0.685755806793271 0.846153846153846 15.1 15 1 tight skin 0.02793768543671 0.0930434385313076 0.685755806793271 0.846153846153846 15.1 15 1 abnormal digestion 0.02793768543671 0.0930434385313076 0.685755806793271 0.846153846153846 15.1 15 1 absent lateral semicircular canal 0.02793768543671 0.0930434385313076 0.685755806793271 0.846153846153846 15.1 15 1 abnormal afterhyperpolarization 0.02793768543671 0.0930434385313076 0.685755806793271 0.846153846153846 15.1 15 1 abnormal insulin secretion 0.02793768543671 0.0930434385313076 0.685755806793271 0.846153846153846 15.1 15 1 abnormal vestibulocochlear ganglion morphology 0.02793768543671 0.0930434385313076 0.685755806793271 0.846153846153846 15.1 15 1 abnormal retinal inner plexiform layer morphology 0.02793768543671 0.0930434385313076 0.685755806793271 0.846153846153846 15.1 15 1 small otic vesicle 0.02793768543671 0.0930434385313076 0.685755806793271 0.846153846153846 15.1 15 1 decreased endocochlear potential 0.02793768543671 0.0930434385313076 0.685755806793271 0.846153846153846 15.1 15 1 abnormal vertebral arch development 0.02793768543671 0.0930434385313076 0.685755806793271 0.846153846153846 15.1 15 1 orthokeratosis 0.02793768543671 0.0930434385313076 0.685755806793271 0.846153846153846 15.1 15 1 increased prostaglandin level 0.02793768543671 0.0930434385313076 0.685755806793271 0.846153846153846 15.1 15 1 abnormal aorta tunica media morphology 0.02793768543671 0.0930434385313076 0.685755806793271 0.846153846153846 15.1 15 1 abnormal ovary morphology 1.57160511583218e-07 2.52217272621455e-06 0.684877758385085 0.845070422535211 15.1 15 1 abnormal lymphatic vessel morphology 0.000498512874297423 0.00331121702220251 0.683807636887608 0.84375 15.1 15 1 hypoactivity 1.01708895695913e-33 2.53000878043583e-31 0.683606102069781 0.843501326259947 15.1 15 1 abnormal gastrulation 1.06356810204603e-05 0.000113546165400836 0.683311044558714 0.843137254901961 15.1 15 1 abnormal cervical vertebrae morphology 1.06356810204603e-05 0.000113546165400836 0.683311044558714 0.843137254901961 15.1 15 1 increased kidney weight 1.06356810204603e-05 0.000113546165400836 0.683311044558714 0.843137254901961 15.1 15 1 cochlear inner hair cell degeneration 1.06356810204603e-05 0.000113546165400836 0.683311044558714 0.843137254901961 15.1 15 1 abnormal bone mineralization 9.81718439102135e-12 3.23446969174379e-10 0.683179714356031 0.84297520661157 15.1 15 1 abnormal cardiovascular system physiology 1.09422417155297e-12 4.12406458596668e-11 0.682474678531102 0.842105263157895 15.1 15 1 abnormal frontal bone morphology 0.000158037055972499 0.0012342768500207 0.682474678531102 0.842105263157895 15.1 15 1 abnormal reproductive system physiology 0.000158037055972499 0.0012342768500207 0.682474678531102 0.842105263157895 15.1 15 1 hyporesponsive to tactile stimuli 0.000158037055972499 0.0012342768500207 0.682474678531102 0.842105263157895 15.1 15 1 thin dermal layer 0.00813936556335515 0.0356769547821074 0.682474678531102 0.842105263157895 15.1 15 1 increased malignant tumor incidence 0.00813936556335515 0.0356769547821074 0.682474678531102 0.842105263157895 15.1 15 1 decreased germ cell number 0.00813936556335515 0.0356769547821074 0.682474678531102 0.842105263157895 15.1 15 1 abnormal neural crest cell migration 0.00813936556335515 0.0356769547821074 0.682474678531102 0.842105263157895 15.1 15 1 abnormal response to novelty 0.00813936556335515 0.0356769547821074 0.682474678531102 0.842105263157895 15.1 15 1 abnormal digestive system development 0.00813936556335515 0.0356769547821074 0.682474678531102 0.842105263157895 15.1 15 1 abnormal photoreceptor inner segment morphology 0.00813936556335515 0.0356769547821074 0.682474678531102 0.842105263157895 15.1 15 1 increased left ventricle weight 0.00813936556335515 0.0356769547821074 0.682474678531102 0.842105263157895 15.1 15 1 abnormal sternebra morphology 0.00813936556335515 0.0356769547821074 0.682474678531102 0.842105263157895 15.1 15 1 abnormal cochlear inner hair cell morphology 0.00813936556335515 0.0356769547821074 0.682474678531102 0.842105263157895 15.1 15 1 increased circulating VLDL cholesterol level 0.00813936556335515 0.0356769547821074 0.682474678531102 0.842105263157895 15.1 15 1 decreased eye pigmentation 0.00813936556335515 0.0356769547821074 0.682474678531102 0.842105263157895 15.1 15 1 Leydig cell hypoplasia 0.00813936556335515 0.0356769547821074 0.682474678531102 0.842105263157895 15.1 15 1 abnormal behavioral response to xenobiotic 0.00813936556335515 0.0356769547821074 0.682474678531102 0.842105263157895 15.1 15 1 increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 0.00813936556335515 0.0356769547821074 0.682474678531102 0.842105263157895 15.1 15 1 shortened RR interval 0.00813936556335515 0.0356769547821074 0.682474678531102 0.842105263157895 15.1 15 1 embryonic lethality between implantation and somite formation, incomplete penetrance 0.00813936556335515 0.0356769547821074 0.682474678531102 0.842105263157895 15.1 15 1 abnormal eye morphology 3.65598795463154e-13 1.49086394051573e-11 0.682167810420252 0.841726618705036 15.1 15 1 decreased susceptibility to hepatic steatosis 1.1310688214751e-06 1.51672975386485e-05 0.681797620318274 0.841269841269841 15.1 15 1 abnormal astrocyte morphology 5.06282758386512e-05 0.000445797650083699 0.681505254271825 0.840909090909091 15.1 15 1 abnormal amino acid level 5.06282758386512e-05 0.000445797650083699 0.681505254271825 0.840909090909091 15.1 15 1 decreased blood urea nitrogen level 5.06282758386512e-05 0.000445797650083699 0.681505254271825 0.840909090909091 15.1 15 1 decreased spleen weight 3.71035813968746e-07 5.41320579030649e-06 0.68123831135985 0.840579710144927 15.1 15 1 decreased oocyte number 1.63466965988456e-05 0.000166788350329965 0.680768491834774 0.84 15.1 15 1 spontaneous skin ulceration 0.00247140266834918 0.0132491683998245 0.680768491834774 0.84 15.1 15 1 abnormal primitive streak morphology 0.00247140266834918 0.0132491683998245 0.680768491834774 0.84 15.1 15 1 abnormal energy expenditure 0.00247140266834918 0.0132491683998245 0.680768491834774 0.84 15.1 15 1 abnormal bone structure 1.92308988168442e-17 1.29288812991622e-15 0.680264592136895 0.839378238341969 15.1 15 1 short mandible 5.31004716402393e-06 6.17230949556519e-05 0.680189607062806 0.839285714285714 15.1 15 1 abnormal retinal pigmentation 1.33123328053948e-08 2.62812919471583e-07 0.680023260863964 0.839080459770115 15.1 15 1 hypoglycemia 4.40865366747328e-09 9.3730991434528e-08 0.679722764504767 0.838709677419355 15.1 15 1 decreased thymus weight 0.00076881342826677 0.00484157823497111 0.679722764504767 0.838709677419355 15.1 15 1 inner cell mass degeneration 0.00076881342826677 0.00484157823497111 0.679722764504767 0.838709677419355 15.1 15 1 decreased neuronal precursor cell number 0.00076881342826677 0.00484157823497111 0.679722764504767 0.838709677419355 15.1 15 1 abnormal podocyte morphology 0.00076881342826677 0.00484157823497111 0.679722764504767 0.838709677419355 15.1 15 1 abnormal mitochondrial ATP synthesis coupled electron transport 0.00076881342826677 0.00484157823497111 0.679722764504767 0.838709677419355 15.1 15 1 increased mean corpuscular hemoglobin 1.46229130558477e-09 3.33710974554322e-08 0.679458691946684 0.838383838383838 15.1 15 1 decreased bone mineral density 2.50648879092194e-23 3.1973799320094e-21 0.679427916573374 0.838345864661654 15.1 15 1 abnormal liver morphology 3.99799548912062e-16 2.39638886245483e-14 0.679138559292472 0.837988826815642 15.1 15 1 increased brown adipose tissue amount 0.000243005523553799 0.00178835776646816 0.679016191984492 0.837837837837838 15.1 15 1 abnormal chromosome morphology 0.000243005523553799 0.00178835776646816 0.679016191984492 0.837837837837838 15.1 15 1 abnormal retinal pigment epithelium morphology 6.15372806494842e-08 1.08563110365668e-06 0.678742395132885 0.8375 15.1 15 1 postnatal lethality 5.44499480970975e-15 2.79266486374288e-13 0.678620341114699 0.837349397590361 15.1 15 1 decreased oxygen consumption 7.76777169936923e-05 0.000655893118488492 0.678506802493131 0.837209302325581 15.1 15 1 abnormal long bone hypertrophic chondrocyte zone 2.50380455334276e-05 0.0002390869031263 0.678122161448633 0.836734693877551 15.1 15 1 increased circulating LDL cholesterol level 2.50380455334276e-05 0.0002390869031263 0.678122161448633 0.836734693877551 15.1 15 1 increased T cell derived lymphoma incidence 2.50380455334276e-05 0.0002390869031263 0.678122161448633 0.836734693877551 15.1 15 1 abnormal respiratory system physiology 2.50380455334276e-05 0.0002390869031263 0.678122161448633 0.836734693877551 15.1 15 1 decreased circulating creatinine level 2.50380455334276e-05 0.0002390869031263 0.678122161448633 0.836734693877551 15.1 15 1 increased osteoclast cell number 2.64837864997748e-06 3.29392094590949e-05 0.677579880631801 0.836065573770492 15.1 15 1 decreased circulating HDL cholesterol level 9.09225538195368e-12 3.01559803501464e-10 0.677476084694204 0.8359375 15.1 15 1 seminiferous tubule degeneration 2.84816370931036e-07 4.30809032403413e-06 0.677215883919133 0.835616438356164 15.1 15 1 abnormal testis morphology 1.24596236991774e-10 3.40585867601141e-09 0.676540116109092 0.834782608695652 15.1 15 1 increased blood urea nitrogen level 5.13718561698419e-13 2.02837289242034e-11 0.676297106009915 0.83448275862069 15.1 15 1 abnormal cornea morphology 1.42703946377392e-07 2.32010501054747e-06 0.675365567296403 0.833333333333333 15.1 15 1 increased cell proliferation 1.2384424538389e-05 0.00013053498321713 0.675365567296403 0.833333333333333 15.1 15 1 decreased tumor growth/size 1.2384424538389e-05 0.00013053498321713 0.675365567296403 0.833333333333333 15.1 15 1 abnormal osteoblast physiology 1.2384424538389e-05 0.00013053498321713 0.675365567296403 0.833333333333333 15.1 15 1 abnormal malleus morphology 0.00380346770352248 0.0188093954523105 0.675365567296403 0.833333333333333 15.1 15 1 abnormal digestive system morphology 0.00380346770352248 0.0188093954523105 0.675365567296403 0.833333333333333 15.1 15 1 ocular hypertelorism 0.00380346770352248 0.0188093954523105 0.675365567296403 0.833333333333333 15.1 15 1 increased stereotypic behavior 0.00380346770352248 0.0188093954523105 0.675365567296403 0.833333333333333 15.1 15 1 abnormal vasodilation 0.00380346770352248 0.0188093954523105 0.675365567296403 0.833333333333333 15.1 15 1 blindness 0.00380346770352248 0.0188093954523105 0.675365567296403 0.833333333333333 15.1 15 1 abnormal sensory capabilities/reflexes/nociception 0.00380346770352248 0.0188093954523105 0.675365567296403 0.833333333333333 15.1 15 1 abnormal cardiac muscle contractility 0.00380346770352248 0.0188093954523105 0.675365567296403 0.833333333333333 15.1 15 1 prolonged QT interval 0.00380346770352248 0.0188093954523105 0.675365567296403 0.833333333333333 15.1 15 1 abnormal retinal ganglion layer morphology 0.00380346770352248 0.0188093954523105 0.675365567296403 0.833333333333333 15.1 15 1 abnormal inner cell mass apoptosis 0.00380346770352248 0.0188093954523105 0.675365567296403 0.833333333333333 15.1 15 1 abnormal adipose tissue distribution 0.0435830067338669 0.130539108068024 0.675365567296403 0.833333333333333 15.1 15 1 abnormal supraoccipital bone morphology 0.0435830067338669 0.130539108068024 0.675365567296403 0.833333333333333 15.1 15 1 abnormal rectum morphology 0.0435830067338669 0.130539108068024 0.675365567296403 0.833333333333333 15.1 15 1 decreased digestive secretion 0.0435830067338669 0.130539108068024 0.675365567296403 0.833333333333333 15.1 15 1 abnormal superior cervical ganglion morphology 0.0435830067338669 0.130539108068024 0.675365567296403 0.833333333333333 15.1 15 1 abnormal glossopharyngeal nerve morphology 0.0435830067338669 0.130539108068024 0.675365567296403 0.833333333333333 15.1 15 1 absent optic nerve 0.0435830067338669 0.130539108068024 0.675365567296403 0.833333333333333 15.1 15 1 myocarditis 0.0435830067338669 0.130539108068024 0.675365567296403 0.833333333333333 15.1 15 1 interstitial pneumonia 0.0435830067338669 0.130539108068024 0.675365567296403 0.833333333333333 15.1 15 1 abnormal embryonic growth/weight/body size 0.0435830067338669 0.130539108068024 0.675365567296403 0.833333333333333 15.1 15 1 small thyroid gland 0.0435830067338669 0.130539108068024 0.675365567296403 0.833333333333333 15.1 15 1 abnormal gastrocnemius morphology 0.0435830067338669 0.130539108068024 0.675365567296403 0.833333333333333 15.1 15 1 abnormal alisphenoid bone morphology 0.0435830067338669 0.130539108068024 0.675365567296403 0.833333333333333 15.1 15 1 increased hepatocyte proliferation 0.0435830067338669 0.130539108068024 0.675365567296403 0.833333333333333 15.1 15 1 small parietal bone 0.0435830067338669 0.130539108068024 0.675365567296403 0.833333333333333 15.1 15 1 abnormal cochlear outer hair cell physiology 0.0435830067338669 0.130539108068024 0.675365567296403 0.833333333333333 15.1 15 1 abnormal amacrine cell morphology 0.0435830067338669 0.130539108068024 0.675365567296403 0.833333333333333 15.1 15 1 abnormal palatine bone morphology 0.0435830067338669 0.130539108068024 0.675365567296403 0.833333333333333 15.1 15 1 abnormal fatty acid level 0.0435830067338669 0.130539108068024 0.675365567296403 0.833333333333333 15.1 15 1 abnormal patella morphology 0.0435830067338669 0.130539108068024 0.675365567296403 0.833333333333333 15.1 15 1 abnormal thymus corticomedullary boundary morphology 0.0435830067338669 0.130539108068024 0.675365567296403 0.833333333333333 15.1 15 1 decreased keratinocyte proliferation 0.0435830067338669 0.130539108068024 0.675365567296403 0.833333333333333 15.1 15 1 abnormal behavioral response to addictive substance 0.0435830067338669 0.130539108068024 0.675365567296403 0.833333333333333 15.1 15 1 impaired behavioral response to cocaine 0.0435830067338669 0.130539108068024 0.675365567296403 0.833333333333333 15.1 15 1 decreased prostaglandin level 0.0435830067338669 0.130539108068024 0.675365567296403 0.833333333333333 15.1 15 1 increased fibrosarcoma incidence 0.0435830067338669 0.130539108068024 0.675365567296403 0.833333333333333 15.1 15 1 increased skeletal muscle glycogen level 0.0435830067338669 0.130539108068024 0.675365567296403 0.833333333333333 15.1 15 1 persistent right dorsal aorta 0.0435830067338669 0.130539108068024 0.675365567296403 0.833333333333333 15.1 15 1 increased type II pneumocyte number 0.0435830067338669 0.130539108068024 0.675365567296403 0.833333333333333 15.1 15 1 abnormal respiratory motile cilium morphology 0.0435830067338669 0.130539108068024 0.675365567296403 0.833333333333333 15.1 15 1 shiny fur 0.166467785833196 0.324930733948164 0.675365567296403 0.833333333333333 15.1 15 1 ectopic digits 0.166467785833196 0.324930733948164 0.675365567296403 0.833333333333333 15.1 15 1 absent superior cervical ganglion 0.166467785833196 0.324930733948164 0.675365567296403 0.833333333333333 15.1 15 1 increased embryo size 0.166467785833196 0.324930733948164 0.675365567296403 0.833333333333333 15.1 15 1 abnormal gustatory system physiology 0.166467785833196 0.324930733948164 0.675365567296403 0.833333333333333 15.1 15 1 abnormal parental behavior 0.166467785833196 0.324930733948164 0.675365567296403 0.833333333333333 15.1 15 1 abnormal internal nares morphology 0.166467785833196 0.324930733948164 0.675365567296403 0.833333333333333 15.1 15 1 abnormal pulmonary alveolar duct morphology 0.166467785833196 0.324930733948164 0.675365567296403 0.833333333333333 15.1 15 1 abnormal lymph node cortex morphology 0.166467785833196 0.324930733948164 0.675365567296403 0.833333333333333 15.1 15 1 acidemia 0.166467785833196 0.324930733948164 0.675365567296403 0.833333333333333 15.1 15 1 absent cochlea 0.166467785833196 0.324930733948164 0.675365567296403 0.833333333333333 15.1 15 1 decreased posterior semicircular canal size 0.166467785833196 0.324930733948164 0.675365567296403 0.833333333333333 15.1 15 1 phenotypic reversion 0.166467785833196 0.324930733948164 0.675365567296403 0.833333333333333 15.1 15 1 calcified joint 0.166467785833196 0.324930733948164 0.675365567296403 0.833333333333333 15.1 15 1 pancreas fibrosis 0.166467785833196 0.324930733948164 0.675365567296403 0.833333333333333 15.1 15 1 impaired granulosa cell differentiation 0.166467785833196 0.324930733948164 0.675365567296403 0.833333333333333 15.1 15 1 abnormal leukocyte tethering or rolling 0.166467785833196 0.324930733948164 0.675365567296403 0.833333333333333 15.1 15 1 decreased heart right ventricle size 0.166467785833196 0.324930733948164 0.675365567296403 0.833333333333333 15.1 15 1 abnormal periodontal ligament morphology 0.166467785833196 0.324930733948164 0.675365567296403 0.833333333333333 15.1 15 1 fusion of middle ear ossicles 0.166467785833196 0.324930733948164 0.675365567296403 0.833333333333333 15.1 15 1 abnormal milk ejection 0.166467785833196 0.324930733948164 0.675365567296403 0.833333333333333 15.1 15 1 abnormal metopic suture morphology 0.166467785833196 0.324930733948164 0.675365567296403 0.833333333333333 15.1 15 1 abnormal serotonergic neuron morphology 0.166467785833196 0.324930733948164 0.675365567296403 0.833333333333333 15.1 15 1 abnormal ST segment 0.166467785833196 0.324930733948164 0.675365567296403 0.833333333333333 15.1 15 1 absent molars 0.166467785833196 0.324930733948164 0.675365567296403 0.833333333333333 15.1 15 1 abnormal cholesterol level 0.166467785833196 0.324930733948164 0.675365567296403 0.833333333333333 15.1 15 1 abnormal physical strength 0.166467785833196 0.324930733948164 0.675365567296403 0.833333333333333 15.1 15 1 vestibular saccular degeneration 0.166467785833196 0.324930733948164 0.675365567296403 0.833333333333333 15.1 15 1 bowed humerus 0.166467785833196 0.324930733948164 0.675365567296403 0.833333333333333 15.1 15 1 enlarged interparietal bone 0.166467785833196 0.324930733948164 0.675365567296403 0.833333333333333 15.1 15 1 decreased cochlear microphonics 0.166467785833196 0.324930733948164 0.675365567296403 0.833333333333333 15.1 15 1 abnormal immature B cell morphology 0.166467785833196 0.324930733948164 0.675365567296403 0.833333333333333 15.1 15 1 osteomyelitis 0.166467785833196 0.324930733948164 0.675365567296403 0.833333333333333 15.1 15 1 abnormal heart size 0.166467785833196 0.324930733948164 0.675365567296403 0.833333333333333 15.1 15 1 increased triiodothyronine level 0.166467785833196 0.324930733948164 0.675365567296403 0.833333333333333 15.1 15 1 abnormal ligament morphology 0.166467785833196 0.324930733948164 0.675365567296403 0.833333333333333 15.1 15 1 abnormal pulmonary respiratory rate 0.166467785833196 0.324930733948164 0.675365567296403 0.833333333333333 15.1 15 1 urinary bladder obstruction 0.166467785833196 0.324930733948164 0.675365567296403 0.833333333333333 15.1 15 1 abnormal thromboxane level 0.166467785833196 0.324930733948164 0.675365567296403 0.833333333333333 15.1 15 1 exostosis 0.166467785833196 0.324930733948164 0.675365567296403 0.833333333333333 15.1 15 1 absent tongue 0.166467785833196 0.324930733948164 0.675365567296403 0.833333333333333 15.1 15 1 increased transitional stage T1 B cell number 0.166467785833196 0.324930733948164 0.675365567296403 0.833333333333333 15.1 15 1 decreased DN1 thymic pro-T cell number 0.166467785833196 0.324930733948164 0.675365567296403 0.833333333333333 15.1 15 1 abnormal synaptic dopamine release 0.166467785833196 0.324930733948164 0.675365567296403 0.833333333333333 15.1 15 1 abnormal acute phase protein level 0.166467785833196 0.324930733948164 0.675365567296403 0.833333333333333 15.1 15 1 abnormal epiglottis morphology 0.166467785833196 0.324930733948164 0.675365567296403 0.833333333333333 15.1 15 1 common truncal valve 0.166467785833196 0.324930733948164 0.675365567296403 0.833333333333333 15.1 15 1 thick pulmonary valve cusps 0.166467785833196 0.324930733948164 0.675365567296403 0.833333333333333 15.1 15 1 absent third pharyngeal arch 0.166467785833196 0.324930733948164 0.675365567296403 0.833333333333333 15.1 15 1 thick myocardium 0.166467785833196 0.324930733948164 0.675365567296403 0.833333333333333 15.1 15 1 persistent hyperplastic primary vitreous 0.166467785833196 0.324930733948164 0.675365567296403 0.833333333333333 15.1 15 1 increased total lung capacity 0.166467785833196 0.324930733948164 0.675365567296403 0.833333333333333 15.1 15 1 ectopic ureteric bud 0.166467785833196 0.324930733948164 0.675365567296403 0.833333333333333 15.1 15 1 abnormal ureteric bud elongation 0.166467785833196 0.324930733948164 0.675365567296403 0.833333333333333 15.1 15 1 abnormal ureteric bud tip morphology 0.166467785833196 0.324930733948164 0.675365567296403 0.833333333333333 15.1 15 1 abnormal kidney collecting duct epithelium morphology 0.166467785833196 0.324930733948164 0.675365567296403 0.833333333333333 15.1 15 1 podocyte hypertrophy 0.166467785833196 0.324930733948164 0.675365567296403 0.833333333333333 15.1 15 1 absent midbrain 0.166467785833196 0.324930733948164 0.675365567296403 0.833333333333333 15.1 15 1 delayed limb development 0.166467785833196 0.324930733948164 0.675365567296403 0.833333333333333 15.1 15 1 abnormal Rathke's pouch development 0.166467785833196 0.324930733948164 0.675365567296403 0.833333333333333 15.1 15 1 increased bone trabecular spacing 0.166467785833196 0.324930733948164 0.675365567296403 0.833333333333333 15.1 15 1 increased CD11b-high dendritic cell number 0.166467785833196 0.324930733948164 0.675365567296403 0.833333333333333 15.1 15 1 absent thymus corticomedullary boundary 0.166467785833196 0.324930733948164 0.675365567296403 0.833333333333333 15.1 15 1 ciliary body hypoplasia 0.166467785833196 0.324930733948164 0.675365567296403 0.833333333333333 15.1 15 1 absent embryonic telencephalon 0.166467785833196 0.324930733948164 0.675365567296403 0.833333333333333 15.1 15 1 additional anastomosis between intracranial vertebral arteries 0.166467785833196 0.324930733948164 0.675365567296403 0.833333333333333 15.1 15 1 increased male germ cell apoptosis 0.166467785833196 0.324930733948164 0.675365567296403 0.833333333333333 15.1 15 1 abnormal embryo morphology 0.166467785833196 0.324930733948164 0.675365567296403 0.833333333333333 15.1 15 1 increased body fat mass 0.166467785833196 0.324930733948164 0.675365567296403 0.833333333333333 15.1 15 1 ectopic bone 0.166467785833196 0.324930733948164 0.675365567296403 0.833333333333333 15.1 15 1 abnormal inhibitory learning 0.166467785833196 0.324930733948164 0.675365567296403 0.833333333333333 15.1 15 1 decreased retinal apoptosis 0.166467785833196 0.324930733948164 0.675365567296403 0.833333333333333 15.1 15 1 increased cardiac cell glucose uptake 0.166467785833196 0.324930733948164 0.675365567296403 0.833333333333333 15.1 15 1 abnormal neuromuscular synapse morphology 4.33408731297992e-07 6.24987953103626e-06 0.675365567296403 0.833333333333333 15.1 15 1 abnormal uterus morphology 0.000371956168008191 0.00254187079099004 0.675365567296403 0.833333333333333 15.1 15 1 abnormal trophoblast giant cell morphology 0.000371956168008191 0.00254187079099004 0.675365567296403 0.833333333333333 15.1 15 1 narrow eye opening 0.000371956168008191 0.00254187079099004 0.675365567296403 0.833333333333333 15.1 15 1 delayed eyelid opening 0.00117941932681886 0.00700192261446758 0.675365567296403 0.833333333333333 15.1 15 1 abnormal cellular respiration 0.00117941932681886 0.00700192261446758 0.675365567296403 0.833333333333333 15.1 15 1 cortical renal glomerulopathies 0.0125883606208251 0.049585981067779 0.675365567296403 0.833333333333333 15.1 15 1 absent spleen 0.0125883606208251 0.049585981067779 0.675365567296403 0.833333333333333 15.1 15 1 blepharoptosis 0.0125883606208251 0.049585981067779 0.675365567296403 0.833333333333333 15.1 15 1 abnormal redox activity 0.0125883606208251 0.049585981067779 0.675365567296403 0.833333333333333 15.1 15 1 increased circulating glycerol level 0.0125883606208251 0.049585981067779 0.675365567296403 0.833333333333333 15.1 15 1 decreased heart rate variability 0.0125883606208251 0.049585981067779 0.675365567296403 0.833333333333333 15.1 15 1 abnormal eye anterior chamber morphology 0.0125883606208251 0.049585981067779 0.675365567296403 0.833333333333333 15.1 15 1 abnormal glycogen homeostasis 0.0125883606208251 0.049585981067779 0.675365567296403 0.833333333333333 15.1 15 1 decreased lactate dehydrogenase level 0.0125883606208251 0.049585981067779 0.675365567296403 0.833333333333333 15.1 15 1 increased gastrointestinal tumor incidence 0.0125883606208251 0.049585981067779 0.675365567296403 0.833333333333333 15.1 15 1 primary atelectasis 0.0125883606208251 0.049585981067779 0.675365567296403 0.833333333333333 15.1 15 1 abnormal metanephric mesenchyme morphology 0.0125883606208251 0.049585981067779 0.675365567296403 0.833333333333333 15.1 15 1 increased spleen weight 2.86892977080722e-10 7.31944903064919e-09 0.674170230009153 0.831858407079646 15.1 15 1 atelectasis 6.57820663732919e-07 9.27098527498945e-06 0.673463129078667 0.830985915492958 15.1 15 1 abnormal neuron differentiation 4.34224821609375e-10 1.07476044154559e-08 0.672953547413202 0.830357142857143 15.1 15 1 abnormal mesoderm development 1.88192485542553e-05 0.000188381813998833 0.672817017985851 0.830188679245283 15.1 15 1 abnormal pancreatic islet morphology 1.88192485542553e-05 0.000188381813998833 0.672817017985851 0.830188679245283 15.1 15 1 abnormal liver physiology 3.93016158902606e-09 8.39165403665436e-08 0.672664105027217 0.83 15.1 15 1 abnormal suckling behavior 3.57618684829405e-08 6.66349422107224e-07 0.672295723808692 0.829545454545455 15.1 15 1 decreased hematocrit 1.36427162632455e-12 4.99062598600342e-11 0.671664934050943 0.828767123287671 15.1 15 1 abnormal kidney morphology 8.61931517111903e-15 4.20402872316835e-13 0.671506335483281 0.828571428571429 15.1 15 1 ovary cysts 0.0005665986502035 0.00373849905140904 0.671506335483281 0.828571428571429 15.1 15 1 increased sacral vertebrae number 3.03422177709813e-06 3.70890745480668e-05 0.671144532500801 0.828125 15.1 15 1 abnormal enzyme/coenzyme activity 2.29998778594195e-13 9.69698240259424e-12 0.671063875784961 0.828025477707006 15.1 15 1 lethargy 1.78925195029578e-08 3.45020482663625e-07 0.671008370088039 0.827956989247312 15.1 15 1 reduced female fertility 5.25648442934911e-19 4.35850167266864e-17 0.670707873728842 0.827586206896552 15.1 15 1 abnormal microglial cell morphology 0.00179914592747098 0.00992322726071854 0.670707873728842 0.827586206896552 15.1 15 1 abnormal heart morphology 7.91645779736869e-19 6.45645533473922e-17 0.670102978460327 0.826839826839827 15.1 15 1 abnormal spermatogenesis 3.30219972642114e-15 1.72930985673107e-13 0.669492823232956 0.826086956521739 15.1 15 1 abnormal inner ear morphology 8.80047968882413e-05 0.000734603799528524 0.669492823232956 0.826086956521739 15.1 15 1 abnormal sleep pattern 8.80047968882413e-05 0.000734603799528524 0.669492823232956 0.826086956521739 15.1 15 1 abnormal blood vessel physiology 0.00581376938863628 0.0264383022929301 0.669492823232956 0.826086956521739 15.1 15 1 blistering 0.00581376938863628 0.0264383022929301 0.669492823232956 0.826086956521739 15.1 15 1 abnormal postnatal growth 0.00581376938863628 0.0264383022929301 0.669492823232956 0.826086956521739 15.1 15 1 abnormal ulna morphology 0.00581376938863628 0.0264383022929301 0.669492823232956 0.826086956521739 15.1 15 1 abnormal palatal shelf fusion at midline 0.00581376938863628 0.0264383022929301 0.669492823232956 0.826086956521739 15.1 15 1 abnormal epidermal layer morphology 1.50323401149713e-06 1.94249070316837e-05 0.669492823232956 0.826086956521739 15.1 15 1 no abnormal phenotype detected 3.22985602703079e-134 1.60685337344782e-130 0.668903856393164 0.82536023054755 15.1 15 1 abnormal social investigation 2.46009676890305e-07 3.74280777531885e-06 0.668611911623439 0.825 15.1 15 1 head bobbing 0.000273657318997467 0.00197884471222732 0.668611911623439 0.825 15.1 15 1 increased granulocyte number 7.45215886014529e-07 1.03850112967011e-05 0.668064317920226 0.824324324324324 15.1 15 1 azoospermia 3.93518890751547e-13 1.59167193616987e-11 0.667719919364746 0.823899371069182 15.1 15 1 abnormal retina morphology 7.12041952294458e-17 4.60053079566874e-15 0.667647103670158 0.823809523809524 15.1 15 1 increased width of hypertrophic chondrocyte zone 0.000858712772971141 0.00530036730214817 0.667420090034092 0.823529411764706 15.1 15 1 increased susceptibility to weight gain 0.000858712772971141 0.00530036730214817 0.667420090034092 0.823529411764706 15.1 15 1 distended urinary bladder 0.0193020091654104 0.0702468877819434 0.667420090034092 0.823529411764706 15.1 15 1 increased aggression towards mice 0.0193020091654104 0.0702468877819434 0.667420090034092 0.823529411764706 15.1 15 1 abnormal heart rate 0.0193020091654104 0.0702468877819434 0.667420090034092 0.823529411764706 15.1 15 1 decreased vasoconstriction 0.0193020091654104 0.0702468877819434 0.667420090034092 0.823529411764706 15.1 15 1 aminoaciduria 0.0193020091654104 0.0702468877819434 0.667420090034092 0.823529411764706 15.1 15 1 abnormal testis development 0.0193020091654104 0.0702468877819434 0.667420090034092 0.823529411764706 15.1 15 1 abnormal ectoplacental cone morphology 0.0193020091654104 0.0702468877819434 0.667420090034092 0.823529411764706 15.1 15 1 increased circulating magnesium level 0.0193020091654104 0.0702468877819434 0.667420090034092 0.823529411764706 15.1 15 1 increased hepatoma incidence 0.0193020091654104 0.0702468877819434 0.667420090034092 0.823529411764706 15.1 15 1 increased bone mineral density 1.11931789866759e-09 2.62670120088267e-08 0.666998206285651 0.823008849557522 15.1 15 1 enlarged spleen 1.85818256564313e-22 2.14987401490106e-20 0.666923497705198 0.822916666666667 15.1 15 1 decreased B cell proliferation 3.6966535816845e-07 5.41320579030649e-06 0.666816636064803 0.822784810126582 15.1 15 1 increased circulating glucose level 1.04782471169162e-11 3.4295578557012e-10 0.666743879203257 0.822695035460993 15.1 15 1 increased circulating corticosterone level 0.000132751433059688 0.00105501338573793 0.666360693065784 0.822222222222222 15.1 15 1 abnormal seminiferous tubule morphology 5.2536101322129e-12 1.79018564436707e-10 0.666113984182754 0.821917808219178 15.1 15 1 abnormal coat/hair pigmentation 1.67654849003654e-09 3.791285789969e-08 0.665717487763597 0.821428571428571 15.1 15 1 arrest of spermatogenesis 1.83482859060094e-07 2.85258507444989e-06 0.665717487763597 0.821428571428571 15.1 15 1 decreased exploration in new environment 1.83482859060094e-07 2.85258507444989e-06 0.665717487763597 0.821428571428571 15.1 15 1 abnormal stria vascularis morphology 0.00272802502150119 0.0140787598360668 0.665717487763597 0.821428571428571 15.1 15 1 reddish skin 0.00272802502150119 0.0140787598360668 0.665717487763597 0.821428571428571 15.1 15 1 failure of blastocyst to hatch from the zona pellucida 0.00272802502150119 0.0140787598360668 0.665717487763597 0.821428571428571 15.1 15 1 extramedullary hematopoiesis 5.02574703725593e-09 1.04615445649993e-07 0.665171370054193 0.820754716981132 15.1 15 1 abnormal iris morphology 0.000412677382258315 0.00281600440508968 0.664975327799535 0.82051282051282 15.1 15 1 increased body length 6.46319684576335e-05 0.000558236185897095 0.664559718219661 0.82 15.1 15 1 anemia 1.79331999567338e-16 1.08802036322867e-14 0.664482899387361 0.819905213270142 15.1 15 1 female infertility 2.45520472349803e-20 2.54471739570889e-18 0.664194106784733 0.819548872180451 15.1 15 1 reduced male fertility 1.51872132379087e-17 1.03501898436433e-15 0.664059888196287 0.819383259911894 15.1 15 1 deafness 2.25096452000228e-08 4.27425514771425e-07 0.663086193345559 0.818181818181818 15.1 15 1 hyperglycemia 1.36115478345916e-07 2.22024427793748e-06 0.663086193345559 0.818181818181818 15.1 15 1 increased liver weight 1.36115478345916e-07 2.22024427793748e-06 0.663086193345559 0.818181818181818 15.1 15 1 small kidney 1.36115478345916e-07 2.22024427793748e-06 0.663086193345559 0.818181818181818 15.1 15 1 cochlear hair cell degeneration 0.00019940020219138 0.00152149694156767 0.663086193345559 0.818181818181818 15.1 15 1 abnormal long bone epiphysis morphology 0.00882118649917565 0.0361196731139085 0.663086193345559 0.818181818181818 15.1 15 1 abnormal enterocyte morphology 0.00882118649917565 0.0361196731139085 0.663086193345559 0.818181818181818 15.1 15 1 abnormal chorion morphology 0.00882118649917565 0.0361196731139085 0.663086193345559 0.818181818181818 15.1 15 1 increased coping response 0.00882118649917565 0.0361196731139085 0.663086193345559 0.818181818181818 15.1 15 1 abnormal tracheal cartilage morphology 0.00882118649917565 0.0361196731139085 0.663086193345559 0.818181818181818 15.1 15 1 parakeratosis 0.00882118649917565 0.0361196731139085 0.663086193345559 0.818181818181818 15.1 15 1 abnormal mesenteric lymph node morphology 0.00882118649917565 0.0361196731139085 0.663086193345559 0.818181818181818 15.1 15 1 increased mammary gland tumor incidence 0.00882118649917565 0.0361196731139085 0.663086193345559 0.818181818181818 15.1 15 1 abnormal ear position 0.0671900749092982 0.175562301824453 0.663086193345559 0.818181818181818 15.1 15 1 abnormal sphenoid bone morphology 0.0671900749092982 0.175562301824453 0.663086193345559 0.818181818181818 15.1 15 1 abnormal stomach epithelium morphology 0.0671900749092982 0.175562301824453 0.663086193345559 0.818181818181818 15.1 15 1 abnormal sebaceous gland morphology 0.0671900749092982 0.175562301824453 0.663086193345559 0.818181818181818 15.1 15 1 abnormal glossopharyngeal ganglion morphology 0.0671900749092982 0.175562301824453 0.663086193345559 0.818181818181818 15.1 15 1 abnormal eye distance/ position 0.0671900749092982 0.175562301824453 0.663086193345559 0.818181818181818 15.1 15 1 social withdrawal 0.0671900749092982 0.175562301824453 0.663086193345559 0.818181818181818 15.1 15 1 abnormal food preference 0.0671900749092982 0.175562301824453 0.663086193345559 0.818181818181818 15.1 15 1 abnormal hemoglobin 0.0671900749092982 0.175562301824453 0.663086193345559 0.818181818181818 15.1 15 1 abnormal hypothalamus secretion 0.0671900749092982 0.175562301824453 0.663086193345559 0.818181818181818 15.1 15 1 vasculitis 0.0671900749092982 0.175562301824453 0.663086193345559 0.818181818181818 15.1 15 1 decreased post-tetanic potentiation 0.0671900749092982 0.175562301824453 0.663086193345559 0.818181818181818 15.1 15 1 fused joints 0.0671900749092982 0.175562301824453 0.663086193345559 0.818181818181818 15.1 15 1 impaired luteinization 0.0671900749092982 0.175562301824453 0.663086193345559 0.818181818181818 15.1 15 1 abnormal ureter development 0.0671900749092982 0.175562301824453 0.663086193345559 0.818181818181818 15.1 15 1 pathological neovascularization 0.0671900749092982 0.175562301824453 0.663086193345559 0.818181818181818 15.1 15 1 abnormal coronal suture morphology 0.0671900749092982 0.175562301824453 0.663086193345559 0.818181818181818 15.1 15 1 increased circulating triiodothyronine level 0.0671900749092982 0.175562301824453 0.663086193345559 0.818181818181818 15.1 15 1 abnormal superovulation 0.0671900749092982 0.175562301824453 0.663086193345559 0.818181818181818 15.1 15 1 enhanced behavioral response to addictive substance 0.0671900749092982 0.175562301824453 0.663086193345559 0.818181818181818 15.1 15 1 abnormal aorta smooth muscle morphology 0.0671900749092982 0.175562301824453 0.663086193345559 0.818181818181818 15.1 15 1 common atrioventricular valve 0.0671900749092982 0.175562301824453 0.663086193345559 0.818181818181818 15.1 15 1 increased subcutaneous adipose tissue amount 0.0671900749092982 0.175562301824453 0.663086193345559 0.818181818181818 15.1 15 1 decreased core body temperature 0.0671900749092982 0.175562301824453 0.663086193345559 0.818181818181818 15.1 15 1 abnormal brain ependyma motile cilium morphology 0.0671900749092982 0.175562301824453 0.663086193345559 0.818181818181818 15.1 15 1 chylous ascites 0.0671900749092982 0.175562301824453 0.663086193345559 0.818181818181818 15.1 15 1 abnormal joint morphology 3.15630498948717e-05 0.000292959278408557 0.663086193345559 0.818181818181818 15.1 15 1 abnormal platelet physiology 3.15630498948717e-05 0.000292959278408557 0.663086193345559 0.818181818181818 15.1 15 1 belly spot 0.0012944315124617 0.0076120529249373 0.663086193345559 0.818181818181818 15.1 15 1 dextrocardia 0.0012944315124617 0.0076120529249373 0.663086193345559 0.818181818181818 15.1 15 1 abnormal middle ear ossicle morphology 0.0012944315124617 0.0076120529249373 0.663086193345559 0.818181818181818 15.1 15 1 head tossing 0.0012944315124617 0.0076120529249373 0.663086193345559 0.818181818181818 15.1 15 1 cardiovascular system phenotype 0.0012944315124617 0.0076120529249373 0.663086193345559 0.818181818181818 15.1 15 1 decreased sensitivity to xenobiotic induced morbidity/mortality 0.0012944315124617 0.0076120529249373 0.663086193345559 0.818181818181818 15.1 15 1 myeloid hyperplasia 0.0012944315124617 0.0076120529249373 0.663086193345559 0.818181818181818 15.1 15 1 cachexia 1.11955292150476e-08 2.22791031379446e-07 0.662377767925318 0.817307692307692 15.1 15 1 microphthalmia 4.37350010033267e-12 1.52154986008077e-10 0.662123105192552 0.816993464052288 15.1 15 1 corneal opacity 2.50357923635054e-06 3.12163075209122e-05 0.662048499772249 0.816901408450704 15.1 15 1 increased erythrocyte cell number 1.54537611535744e-05 0.000159507182031188 0.661858255950475 0.816666666666667 15.1 15 1 increased bone marrow cell number 0.000619294451413845 0.00399609584407767 0.661147344827005 0.815789473684211 15.1 15 1 decreased threshold for auditory brainstem response 0.000619294451413845 0.00399609584407767 0.661147344827005 0.815789473684211 15.1 15 1 abnormal cochlea morphology 4.71324742240674e-05 0.000417975150204519 0.660357443578705 0.814814814814815 15.1 15 1 abnormal brain commissure morphology 0.00410988617303446 0.0202242173203229 0.660357443578705 0.814814814814815 15.1 15 1 abnormal type II pneumocyte morphology 0.00410988617303446 0.0202242173203229 0.660357443578705 0.814814814814815 15.1 15 1 abnormal action potential 3.7282402044464e-06 4.43731938208633e-05 0.659928640043914 0.814285714285714 15.1 15 1 abnormal organ of Corti morphology 0.000298181353895945 0.00214993077627873 0.659659391312766 0.813953488372093 15.1 15 1 increased circulating triglyceride level 2.86676553033869e-11 8.969911014739e-10 0.659529409166694 0.813793103448276 15.1 15 1 increased total body fat amount 1.70792001212312e-10 4.44863982215316e-09 0.659237434346041 0.813432835820896 15.1 15 1 retinal degeneration 7.39309470251668e-08 1.27710576892432e-06 0.658481428113993 0.8125 15.1 15 1 abnormal cardiovascular system morphology 0.000144297412633582 0.00113409103926077 0.658481428113993 0.8125 15.1 15 1 decreased lymphocyte cell number 5.07662461628745e-10 1.23804938558971e-08 0.658481428113993 0.8125 15.1 15 1 kidney cortex cysts 0.00194011582880061 0.0106183457076821 0.658481428113993 0.8125 15.1 15 1 polydipsia 0.00194011582880061 0.0106183457076821 0.658481428113993 0.8125 15.1 15 1 failure of primitive streak formation 0.00194011582880061 0.0106183457076821 0.658481428113993 0.8125 15.1 15 1 abnormal diaphragm morphology 0.00194011582880061 0.0106183457076821 0.658481428113993 0.8125 15.1 15 1 abnormal heart atrium morphology 0.00194011582880061 0.0106183457076821 0.658481428113993 0.8125 15.1 15 1 abnormal serotonin level 0.00194011582880061 0.0106183457076821 0.658481428113993 0.8125 15.1 15 1 abnormal bone marrow cell number 0.0293136498999349 0.0943307944710065 0.658481428113993 0.8125 15.1 15 1 decreased mast cell number 0.0293136498999349 0.0943307944710065 0.658481428113993 0.8125 15.1 15 1 reduced male mating frequency 0.0293136498999349 0.0943307944710065 0.658481428113993 0.8125 15.1 15 1 poor circulation 0.0293136498999349 0.0943307944710065 0.658481428113993 0.8125 15.1 15 1 abnormal pulmonary elastic fiber morphology 0.0293136498999349 0.0943307944710065 0.658481428113993 0.8125 15.1 15 1 increased pancreatic beta cell number 0.0293136498999349 0.0943307944710065 0.658481428113993 0.8125 15.1 15 1 abnormal amnion morphology 0.0293136498999349 0.0943307944710065 0.658481428113993 0.8125 15.1 15 1 decreased creatinine clearance 0.0293136498999349 0.0943307944710065 0.658481428113993 0.8125 15.1 15 1 increased heart left ventricle size 0.0293136498999349 0.0943307944710065 0.658481428113993 0.8125 15.1 15 1 dilated respiratory conducting tubes 0.0293136498999349 0.0943307944710065 0.658481428113993 0.8125 15.1 15 1 decreased midbrain size 0.0293136498999349 0.0943307944710065 0.658481428113993 0.8125 15.1 15 1 decreased adipocyte glucose uptake 0.0293136498999349 0.0943307944710065 0.658481428113993 0.8125 15.1 15 1 thymus hypoplasia 1.25968718181039e-10 3.42455941503099e-09 0.657747335106062 0.811594202898551 15.1 15 1 improved glucose tolerance 1.868930726679e-14 8.94031765887308e-13 0.657447705306907 0.811224489795918 15.1 15 1 decreased circulating chloride level 0.00092460178709845 0.00567888134668492 0.65711244385596 0.810810810810811 15.1 15 1 abnormal hair follicle development 0.00092460178709845 0.00567888134668492 0.65711244385596 0.810810810810811 15.1 15 1 increased trabecular bone volume 0.00092460178709845 0.00567888134668492 0.65711244385596 0.810810810810811 15.1 15 1 decreased birth weight 1.09404877798818e-07 1.8142975568304e-06 0.656881878086186 0.810526315789474 15.1 15 1 abnormal spermiogenesis 3.41862915689398e-05 0.000314374862394594 0.656734793026157 0.810344827586207 15.1 15 1 thrombocytosis 3.41862915689398e-05 0.000314374862394594 0.656734793026157 0.810344827586207 15.1 15 1 increased monocyte cell number 5.41921872852624e-08 9.73307334816536e-07 0.656455331412104 0.81 15.1 15 1 decreased double-positive T cell number 5.41921872852624e-08 9.73307334816536e-07 0.656455331412104 0.81 15.1 15 1 cataract 2.22889677331572e-09 4.9283384209981e-08 0.656388353008735 0.809917355371901 15.1 15 1 abnormal cartilage morphology 0.000443826293706834 0.00297717981260781 0.656069408230792 0.80952380952381 15.1 15 1 disheveled coat 0.000443826293706834 0.00297717981260781 0.656069408230792 0.80952380952381 15.1 15 1 abnormal anxiety-related response 0.0132771309365529 0.0520047737756264 0.656069408230792 0.80952380952381 15.1 15 1 abnormal hematopoietic system physiology 0.0132771309365529 0.0520047737756264 0.656069408230792 0.80952380952381 15.1 15 1 increased acute inflammation 0.0132771309365529 0.0520047737756264 0.656069408230792 0.80952380952381 15.1 15 1 abnormal clavicle morphology 0.0132771309365529 0.0520047737756264 0.656069408230792 0.80952380952381 15.1 15 1 abnormal hair follicle morphology 1.67155804645788e-05 0.000168599039178118 0.656069408230791 0.80952380952381 15.1 15 1 abnormal tibia morphology 0.000214252295362972 0.00161012865472929 0.655248295079063 0.808510638297872 15.1 15 1 decreased bone marrow cell number 4.02402500151193e-06 4.75523144477954e-05 0.655012084446374 0.808219178082192 15.1 15 1 small testis 2.8118465605623e-19 2.5434430252359e-17 0.654810963074339 0.807971014492754 15.1 15 1 abnormal Schwann cell morphology 0.006149032292877 0.0279118938476853 0.654585088302667 0.807692307692308 15.1 15 1 male infertility 9.19484882470824e-34 2.40759857383808e-31 0.654151300967808 0.807157057654076 15.1 15 1 abnormal circulating amino acid level 5.05724212577332e-05 0.000445797650083699 0.654038233592306 0.807017543859649 15.1 15 1 thrombocytopenia 1.00066111405849e-10 2.82857331956873e-09 0.653940176885621 0.806896551724138 15.1 15 1 decreased circulating glucose level 3.03478087860295e-19 2.69607765554459e-17 0.653579581254584 0.806451612903226 15.1 15 1 prenatal lethality 2.46925001914548e-05 0.0002390869031263 0.653579581254583 0.806451612903226 15.1 15 1 increased circulating insulin level 1.23663641297153e-11 3.99497802242428e-10 0.65341618635927 0.80625 15.1 15 1 impaired wound healing 0.00137297464786978 0.00799830078823439 0.652853381719856 0.805555555555556 15.1 15 1 abnormal retinal blood vessel morphology 0.00137297464786978 0.00799830078823439 0.652853381719856 0.805555555555556 15.1 15 1 abnormal developmental patterning 1.43564215826893e-06 1.86483544057126e-05 0.652304304022867 0.804878048780488 15.1 15 1 arrested B cell differentiation 0.000657394378281709 0.00419837873164506 0.652304304022867 0.804878048780488 15.1 15 1 hemopericardium 0.000657394378281709 0.00419837873164506 0.652304304022867 0.804878048780488 15.1 15 1 increased bone trabecula number 0.000657394378281709 0.00419837873164506 0.652304304022867 0.804878048780488 15.1 15 1 increased lung adenocarcinoma incidence 0.000153330818345554 0.00120318741525099 0.651529135509471 0.803921568627451 15.1 15 1 infertility 4.23518434723347e-08 7.74633901745827e-07 0.651380621915783 0.803738317757009 15.1 15 1 increased body weight 2.14181469900681e-15 1.1709371568746e-13 0.651245368464389 0.803571428571429 15.1 15 1 decreased liver weight 8.71435986026539e-06 9.54932605833047e-05 0.65063387046583 0.802816901408451 15.1 15 1 abnormal skeleton development 2.10649472769629e-06 2.68025863690257e-05 0.650352027766907 0.802469135802469 15.1 15 1 decreased heart weight 2.10649472769629e-06 2.68025863690257e-05 0.650352027766907 0.802469135802469 15.1 15 1 increased circulating cholesterol level 3.49932571264763e-12 1.22599615636775e-10 0.64927189765086 0.801136363636364 15.1 15 1 decreased litter size 1.59210219800195e-18 1.25725530715234e-16 0.648927769288359 0.800711743772242 15.1 15 1 alopecia 3.70006679148384e-07 5.41320579030649e-06 0.648350944604547 0.8 15.1 15 1 increased urine glucose level 0.0198092678989929 0.0715694319516991 0.648350944604547 0.8 15.1 15 1 abnormal trachea morphology 0.0198092678989929 0.0715694319516991 0.648350944604547 0.8 15.1 15 1 abnormal lens epithelium morphology 0.0198092678989929 0.0715694319516991 0.648350944604547 0.8 15.1 15 1 kidney atrophy 0.0198092678989929 0.0715694319516991 0.648350944604547 0.8 15.1 15 1 decreased circulating VLDL cholesterol level 0.0198092678989929 0.0715694319516991 0.648350944604547 0.8 15.1 15 1 abnormal otic capsule morphology 0.102162062131065 0.237623848428959 0.648350944604547 0.8 15.1 15 1 abnormal auchene hair morphology 0.102162062131065 0.237623848428959 0.648350944604547 0.8 15.1 15 1 jaundice 0.102162062131065 0.237623848428959 0.648350944604547 0.8 15.1 15 1 enlarged testis 0.102162062131065 0.237623848428959 0.648350944604547 0.8 15.1 15 1 abnormal prostate gland epithelium morphology 0.102162062131065 0.237623848428959 0.648350944604547 0.8 15.1 15 1 fused cornea and lens 0.102162062131065 0.237623848428959 0.648350944604547 0.8 15.1 15 1 abnormal optic nerve innervation 0.102162062131065 0.237623848428959 0.648350944604547 0.8 15.1 15 1 abnormal mammary gland physiology 0.102162062131065 0.237623848428959 0.648350944604547 0.8 15.1 15 1 abnormal gland morphology 0.102162062131065 0.237623848428959 0.648350944604547 0.8 15.1 15 1 abnormal airway responsiveness 0.102162062131065 0.237623848428959 0.648350944604547 0.8 15.1 15 1 abnormal PNS synaptic transmission 0.102162062131065 0.237623848428959 0.648350944604547 0.8 15.1 15 1 peritoneal inflammation 0.102162062131065 0.237623848428959 0.648350944604547 0.8 15.1 15 1 abnormal glial cell physiology 0.102162062131065 0.237623848428959 0.648350944604547 0.8 15.1 15 1 abnormal pillar cell morphology 0.102162062131065 0.237623848428959 0.648350944604547 0.8 15.1 15 1 abnormal ear physiology 0.102162062131065 0.237623848428959 0.648350944604547 0.8 15.1 15 1 abnormal embryonic erythrocyte morphology 0.102162062131065 0.237623848428959 0.648350944604547 0.8 15.1 15 1 decreased cochlear inner hair cell number 0.102162062131065 0.237623848428959 0.648350944604547 0.8 15.1 15 1 ascites 0.102162062131065 0.237623848428959 0.648350944604547 0.8 15.1 15 1 abnormal gonadal fat pad morphology 0.102162062131065 0.237623848428959 0.648350944604547 0.8 15.1 15 1 increased susceptibility to atherosclerosis 0.102162062131065 0.237623848428959 0.648350944604547 0.8 15.1 15 1 vascular smooth muscle hyperplasia 0.102162062131065 0.237623848428959 0.648350944604547 0.8 15.1 15 1 increased platelet aggregation 0.102162062131065 0.237623848428959 0.648350944604547 0.8 15.1 15 1 abnormal cerebellar granule cell migration 0.102162062131065 0.237623848428959 0.648350944604547 0.8 15.1 15 1 umbilical hernia 0.102162062131065 0.237623848428959 0.648350944604547 0.8 15.1 15 1 abnormal vibrissa follicle morphology 0.102162062131065 0.237623848428959 0.648350944604547 0.8 15.1 15 1 increased kidney iron level 0.102162062131065 0.237623848428959 0.648350944604547 0.8 15.1 15 1 aorta stenosis 0.102162062131065 0.237623848428959 0.648350944604547 0.8 15.1 15 1 sinus bradycardia 0.102162062131065 0.237623848428959 0.648350944604547 0.8 15.1 15 1 abnormal pulmonary interalveolar septum morphology 0.102162062131065 0.237623848428959 0.648350944604547 0.8 15.1 15 1 abnormal adaptive thermogenesis 0.102162062131065 0.237623848428959 0.648350944604547 0.8 15.1 15 1 decreased macrophage cytokine production 0.102162062131065 0.237623848428959 0.648350944604547 0.8 15.1 15 1 decreased macrophage apoptosis 0.102162062131065 0.237623848428959 0.648350944604547 0.8 15.1 15 1 decreased insulin secretion 7.49078998545628e-07 1.04096872004595e-05 0.648350944604547 0.8 15.1 15 1 abnormal cell migration 0.000465995278718149 0.00310767628903859 0.648350944604547 0.8 15.1 15 1 abnormal artery morphology 0.0020271692640417 0.0110461852011034 0.648350944604547 0.8 15.1 15 1 abnormal lactation 0.00427805233007944 0.0209345755022411 0.648350944604547 0.8 15.1 15 1 abnormal microglial cell physiology 0.00427805233007944 0.0209345755022411 0.648350944604547 0.8 15.1 15 1 abnormal preimplantation embryo development 0.00913172784421562 0.0372685365258185 0.648350944604547 0.8 15.1 15 1 abnormal fontanelle morphology 0.0440430745045667 0.130814504871773 0.648350944604547 0.8 15.1 15 1 decreased hepatocyte number 0.0440430745045667 0.130814504871773 0.648350944604547 0.8 15.1 15 1 decreased salivation 0.0440430745045667 0.130814504871773 0.648350944604547 0.8 15.1 15 1 abnormal epidermis stratum spinosum morphology 0.0440430745045667 0.130814504871773 0.648350944604547 0.8 15.1 15 1 audiogenic seizures 0.0440430745045667 0.130814504871773 0.648350944604547 0.8 15.1 15 1 placental labyrinth hypoplasia 0.0440430745045667 0.130814504871773 0.648350944604547 0.8 15.1 15 1 abnormal respiratory system morphology 0.0440430745045667 0.130814504871773 0.648350944604547 0.8 15.1 15 1 abnormal cricoid cartilage morphology 0.0440430745045667 0.130814504871773 0.648350944604547 0.8 15.1 15 1 altered righting response 0.0440430745045667 0.130814504871773 0.648350944604547 0.8 15.1 15 1 increased alcohol consumption 0.0440430745045667 0.130814504871773 0.648350944604547 0.8 15.1 15 1 dilated ureter 0.0440430745045667 0.130814504871773 0.648350944604547 0.8 15.1 15 1 abnormal dendritic cell morphology 0.0440430745045667 0.130814504871773 0.648350944604547 0.8 15.1 15 1 decreased thymocyte apoptosis 0.0440430745045667 0.130814504871773 0.648350944604547 0.8 15.1 15 1 abnormal coronary vessel morphology 0.0440430745045667 0.130814504871773 0.648350944604547 0.8 15.1 15 1 abnormal renal glomerulus morphology 6.53787094472988e-08 1.14144506942037e-06 0.646863901153619 0.798165137614679 15.1 15 1 abnormal tooth morphology 3.80507188673233e-05 0.000348623068812032 0.645818323727185 0.796875 15.1 15 1 diluted coat color 0.000159961872893198 0.0012453995581278 0.645349319861007 0.796296296296296 15.1 15 1 increased fluid intake 0.00032965431054922 0.00232958834514541 0.645043031621871 0.795918367346939 15.1 15 1 abnormal myelopoiesis 0.000682330277191479 0.00434647007557953 0.644667132419294 0.795454545454545 15.1 15 1 renal interstitial fibrosis 0.000682330277191479 0.00434647007557953 0.644667132419294 0.795454545454545 15.1 15 1 abnormal lipid level 3.22110203300027e-06 3.92627218661603e-05 0.644445216022592 0.795180722891566 15.1 15 1 increased urine protein level 6.54080650669755e-06 7.48057755651042e-05 0.6441948488058 0.794871794871795 15.1 15 1 decreased percent body fat/body weight 1.33039347906123e-05 0.000139048478116168 0.643910184709995 0.794520547945205 15.1 15 1 decreased mean corpuscular hemoglobin 2.71118149341224e-05 0.000257084794721938 0.64358365824716 0.794117647058823 15.1 15 1 short maxilla 0.00297506093621102 0.0152586888223194 0.64358365824716 0.794117647058823 15.1 15 1 abnormal oocyte morphology 0.00297506093621102 0.0152586888223194 0.64358365824716 0.794117647058823 15.1 15 1 abnormal endoderm development 0.00297506093621102 0.0152586888223194 0.64358365824716 0.794117647058823 15.1 15 1 abnormal embryonic erythropoiesis 0.00628872821528366 0.0284422026100329 0.642761712323473 0.793103448275862 15.1 15 1 abnormal coat/ hair morphology 0.00023288696220382 0.00172669543511774 0.642234426259221 0.792452830188679 15.1 15 1 abnormal heart left ventricle morphology 1.92916753649159e-05 0.000192336843568049 0.641597288931583 0.791666666666667 15.1 15 1 abnormal body weight 0.0134529157920688 0.0524927498553272 0.641597288931583 0.791666666666667 15.1 15 1 apnea 0.0134529157920688 0.0524927498553272 0.641597288931583 0.791666666666667 15.1 15 1 abnormal tumor morphology 0.0134529157920688 0.0524927498553272 0.641597288931583 0.791666666666667 15.1 15 1 decreased fatty acid level 0.0134529157920688 0.0524927498553272 0.641597288931583 0.791666666666667 15.1 15 1 abnormal B cell differentiation 1.64608488784086e-06 2.12157313912131e-05 0.641226208949552 0.791208791208791 15.1 15 1 abnormal male reproductive system morphology 0.000994040510770196 0.00600893261370805 0.640811980132401 0.790697674418605 15.1 15 1 abnormal homeostasis 0.000994040510770196 0.00600893261370805 0.640811980132401 0.790697674418605 15.1 15 1 irregular coat pigmentation 0.0292720920863376 0.0943307944710065 0.639820011122908 0.789473684210526 15.1 15 1 enlarged adrenal glands 0.0292720920863376 0.0943307944710065 0.639820011122908 0.789473684210526 15.1 15 1 decreased tumor incidence 0.0292720920863376 0.0943307944710065 0.639820011122908 0.789473684210526 15.1 15 1 abnormal ear morphology 0.0292720920863376 0.0943307944710065 0.639820011122908 0.789473684210526 15.1 15 1 increased susceptibility to ischemic brain injury 0.0292720920863376 0.0943307944710065 0.639820011122908 0.789473684210526 15.1 15 1 osteoarthritis 0.0292720920863376 0.0943307944710065 0.639820011122908 0.789473684210526 15.1 15 1 oliguria 0.0292720920863376 0.0943307944710065 0.639820011122908 0.789473684210526 15.1 15 1 absent amnion 0.0292720920863376 0.0943307944710065 0.639820011122908 0.789473684210526 15.1 15 1 increased liver cholesterol level 0.0292720920863376 0.0943307944710065 0.639820011122908 0.789473684210526 15.1 15 1 decreased circulating magnesium level 0.0292720920863376 0.0943307944710065 0.639820011122908 0.789473684210526 15.1 15 1 decreased susceptibility to weight gain 0.0292720920863376 0.0943307944710065 0.639820011122908 0.789473684210526 15.1 15 1 thin interventricular septum 0.0292720920863376 0.0943307944710065 0.639820011122908 0.789473684210526 15.1 15 1 right-sided stomach 0.0292720920863376 0.0943307944710065 0.639820011122908 0.789473684210526 15.1 15 1 abnormal hair growth 0.000337577271113922 0.00238219421814434 0.638999729057366 0.788461538461538 15.1 15 1 abnormal tail morphology 5.67958428221894e-05 0.000493984821748937 0.638527445443872 0.787878787878788 15.1 15 1 abnormal aorta morphology 0.00433837186091661 0.0210569756176196 0.638527445443872 0.787878787878788 15.1 15 1 abnormal spleen morphology 7.326050130549e-11 2.09466088502766e-09 0.638104018755912 0.78735632183908 15.1 15 1 abnormal innervation 0.000695802690339156 0.00442096856249974 0.638004918892772 0.787234042553192 15.1 15 1 spleen hyperplasia 1.97598702986378e-05 0.000196610709471446 0.637545095527804 0.786666666666667 15.1 15 1 abnormal glucose homeostasis 3.75785544269434e-11 1.12651260054388e-09 0.63677324916518 0.785714285714286 15.1 15 1 abnormal eye development 0.000237301269405708 0.00175419586224874 0.63677324916518 0.785714285714286 15.1 15 1 abnormal seminal vesicle morphology 0.000237301269405708 0.00175419586224874 0.63677324916518 0.785714285714286 15.1 15 1 abnormal muscle morphology 0.00144047735505625 0.00830971290514029 0.63677324916518 0.785714285714286 15.1 15 1 lymphoid hyperplasia 0.00917671039532306 0.0373601753001082 0.63677324916518 0.785714285714286 15.1 15 1 abnormal retinal inner nuclear layer morphology 0.00917671039532306 0.0373601753001082 0.63677324916518 0.785714285714286 15.1 15 1 abnormal renal tubule epithelium morphology 0.00917671039532306 0.0373601753001082 0.63677324916518 0.785714285714286 15.1 15 1 abnormal placing response 0.0653795430865482 0.173658957210666 0.63677324916518 0.785714285714286 15.1 15 1 abnormal olfactory system physiology 0.0653795430865482 0.173658957210666 0.63677324916518 0.785714285714286 15.1 15 1 absent otoliths 0.0653795430865482 0.173658957210666 0.63677324916518 0.785714285714286 15.1 15 1 abnormal prepulse inhibition 0.0653795430865482 0.173658957210666 0.63677324916518 0.785714285714286 15.1 15 1 intestinal obstruction 0.0653795430865482 0.173658957210666 0.63677324916518 0.785714285714286 15.1 15 1 abnormal uterus development 0.0653795430865482 0.173658957210666 0.63677324916518 0.785714285714286 15.1 15 1 abnormal sagittal suture morphology 0.0653795430865482 0.173658957210666 0.63677324916518 0.785714285714286 15.1 15 1 enlarged stomach 0.0653795430865482 0.173658957210666 0.63677324916518 0.785714285714286 15.1 15 1 abnormal squamosal bone morphology 0.0653795430865482 0.173658957210666 0.63677324916518 0.785714285714286 15.1 15 1 abnormal positive T cell selection 0.0653795430865482 0.173658957210666 0.63677324916518 0.785714285714286 15.1 15 1 premature hair loss 0.0653795430865482 0.173658957210666 0.63677324916518 0.785714285714286 15.1 15 1 abnormal glucose tolerance 0.0653795430865482 0.173658957210666 0.63677324916518 0.785714285714286 15.1 15 1 spina bifida occulta 0.0653795430865482 0.173658957210666 0.63677324916518 0.785714285714286 15.1 15 1 increased pulmonary respiratory rate 0.0653795430865482 0.173658957210666 0.63677324916518 0.785714285714286 15.1 15 1 increased lung compliance 0.0653795430865482 0.173658957210666 0.63677324916518 0.785714285714286 15.1 15 1 decreased compact bone area 0.0653795430865482 0.173658957210666 0.63677324916518 0.785714285714286 15.1 15 1 thick epidermis 4.01568513412808e-05 0.000362199384820594 0.63677324916518 0.785714285714286 15.1 15 1 impaired hematopoiesis 0.000487108767571295 0.00323979427629304 0.63563818098485 0.784313725490196 15.1 15 1 increased white adipose tissue amount 0.0029983262681659 0.015335158335646 0.635208695727428 0.783783783783784 15.1 15 1 abnormal branching of the mammary ductal tree 0.0029983262681659 0.015335158335646 0.635208695727428 0.783783783783784 15.1 15 1 abnormal eating behavior 0.000166793777302541 0.00128850782931699 0.634843633258619 0.783333333333333 15.1 15 1 failure of embryo implantation 0.0196478880971173 0.0712450752792702 0.634256358852274 0.782608695652174 15.1 15 1 abnormal cardiovascular development 0.0196478880971173 0.0712450752792702 0.634256358852274 0.782608695652174 15.1 15 1 abnormal crista ampullaris morphology 0.0196478880971173 0.0712450752792702 0.634256358852274 0.782608695652174 15.1 15 1 abnormal corneal stroma morphology 0.0196478880971173 0.0712450752792702 0.634256358852274 0.782608695652174 15.1 15 1 abnormal hepatocyte physiology 0.0196478880971173 0.0712450752792702 0.634256358852274 0.782608695652174 15.1 15 1 abnormal coat appearance 5.76332243650777e-05 0.000499521413268748 0.634256358852274 0.782608695652174 15.1 15 1 increased lymphocyte cell number 5.76332243650777e-05 0.000499521413268748 0.634256358852274 0.782608695652174 15.1 15 1 decreased circulating calcium level 0.000341105469405783 0.00240028247566304 0.633615695863535 0.781818181818182 15.1 15 1 decreased B cell number 5.01216120556508e-12 1.73163208317266e-10 0.633401104862452 0.781553398058252 15.1 15 1 increased circulating follicle stimulating hormone level 0.00628371083978094 0.0284422026100329 0.633155219340378 0.78125 15.1 15 1 sparse hair 1.41634042376889e-05 0.000147072067945363 0.632537506931265 0.780487804878049 15.1 15 1 abnormal cholesterol homeostasis 0.00207582699359506 0.0112866003203666 0.632537506931265 0.780487804878049 15.1 15 1 increased thermal nociceptive threshold 4.96221719990922e-06 5.79507759848554e-05 0.632320289380808 0.78021978021978 15.1 15 1 increased circulating chloride level 0.0006995592762805 0.00443351261082228 0.632142170989433 0.78 15.1 15 1 abnormal circulating protein level 0.0006995592762805 0.00443351261082228 0.632142170989433 0.78 15.1 15 1 polyuria 2.86318926308468e-05 0.000266748437899743 0.631510660329104 0.779220779220779 15.1 15 1 abnormal cartilage development 0.00143950277184814 0.00830971290514029 0.63034119614331 0.777777777777778 15.1 15 1 altered response to myocardial infarction 0.00143950277184814 0.00830971290514029 0.63034119614331 0.777777777777778 15.1 15 1 abnormal autopod morphology 0.00143950277184814 0.00830971290514029 0.63034119614331 0.777777777777778 15.1 15 1 abnormal ectoderm development 0.00143950277184814 0.00830971290514029 0.63034119614331 0.777777777777778 15.1 15 1 rectal prolapse 0.0132860437123259 0.0520047737756264 0.63034119614331 0.777777777777778 15.1 15 1 abnormal palate morphology 0.0132860437123259 0.0520047737756264 0.63034119614331 0.777777777777778 15.1 15 1 lowered ear position 0.0427997790714587 0.130539108068024 0.630341196143309 0.777777777777778 15.1 15 1 abnormal megakaryocyte differentiation 0.0427997790714587 0.130539108068024 0.630341196143309 0.777777777777778 15.1 15 1 abnormal radius morphology 0.0427997790714587 0.130539108068024 0.630341196143309 0.777777777777778 15.1 15 1 abnormal mammary gland morphology 0.0427997790714587 0.130539108068024 0.630341196143309 0.777777777777778 15.1 15 1 abnormal phrenic nerve morphology 0.0427997790714587 0.130539108068024 0.630341196143309 0.777777777777778 15.1 15 1 eye inflammation 0.0427997790714587 0.130539108068024 0.630341196143309 0.777777777777778 15.1 15 1 acidosis 0.0427997790714587 0.130539108068024 0.630341196143309 0.777777777777778 15.1 15 1 long tibia 0.0427997790714587 0.130539108068024 0.630341196143309 0.777777777777778 15.1 15 1 abnormal anterior eye segment morphology 0.0427997790714587 0.130539108068024 0.630341196143309 0.777777777777778 15.1 15 1 decreased pulmonary respiratory rate 0.0427997790714587 0.130539108068024 0.630341196143309 0.777777777777778 15.1 15 1 abnormal pregnancy 0.0427997790714587 0.130539108068024 0.630341196143309 0.777777777777778 15.1 15 1 decreased tumor latency 0.0427997790714587 0.130539108068024 0.630341196143309 0.777777777777778 15.1 15 1 abnormal head movements 0.152817765495071 0.324930733948164 0.630341196143309 0.777777777777778 15.1 15 1 crypts of Lieberkuhn abscesses 0.152817765495071 0.324930733948164 0.630341196143309 0.777777777777778 15.1 15 1 absent parathyroid glands 0.152817765495071 0.324930733948164 0.630341196143309 0.777777777777778 15.1 15 1 absent enteric neurons 0.152817765495071 0.324930733948164 0.630341196143309 0.777777777777778 15.1 15 1 wavy vibrissae 0.152817765495071 0.324930733948164 0.630341196143309 0.777777777777778 15.1 15 1 increased pheochromocytoma incidence 0.152817765495071 0.324930733948164 0.630341196143309 0.777777777777778 15.1 15 1 abnormal laryngeal cartilage morphology 0.152817765495071 0.324930733948164 0.630341196143309 0.777777777777778 15.1 15 1 abnormal thymus lobule morphology 0.152817765495071 0.324930733948164 0.630341196143309 0.777777777777778 15.1 15 1 abnormal gut-associated lymphoid tissue morphology 0.152817765495071 0.324930733948164 0.630341196143309 0.777777777777778 15.1 15 1 abnormal postural reflex 0.152817765495071 0.324930733948164 0.630341196143309 0.777777777777778 15.1 15 1 enlarged otoliths 0.152817765495071 0.324930733948164 0.630341196143309 0.777777777777778 15.1 15 1 abnormal abdominal wall morphology 0.152817765495071 0.324930733948164 0.630341196143309 0.777777777777778 15.1 15 1 premature neuronal precursor differentiation 0.152817765495071 0.324930733948164 0.630341196143309 0.777777777777778 15.1 15 1 abnormal ovary physiology 0.152817765495071 0.324930733948164 0.630341196143309 0.777777777777778 15.1 15 1 decreased muscle weight 0.152817765495071 0.324930733948164 0.630341196143309 0.777777777777778 15.1 15 1 abnormal bony labyrinth 0.152817765495071 0.324930733948164 0.630341196143309 0.777777777777778 15.1 15 1 decreased vestibular hair cell number 0.152817765495071 0.324930733948164 0.630341196143309 0.777777777777778 15.1 15 1 short frontal bone 0.152817765495071 0.324930733948164 0.630341196143309 0.777777777777778 15.1 15 1 abnormal posterior eye segment morphology 0.152817765495071 0.324930733948164 0.630341196143309 0.777777777777778 15.1 15 1 absent adrenal gland 0.152817765495071 0.324930733948164 0.630341196143309 0.777777777777778 15.1 15 1 decreased susceptibility to atherosclerosis 0.152817765495071 0.324930733948164 0.630341196143309 0.777777777777778 15.1 15 1 decreased pulmonary ventilation 0.152817765495071 0.324930733948164 0.630341196143309 0.777777777777778 15.1 15 1 abnormal retinal development 0.152817765495071 0.324930733948164 0.630341196143309 0.777777777777778 15.1 15 1 eye opacity 0.152817765495071 0.324930733948164 0.630341196143309 0.777777777777778 15.1 15 1 abnormal heart left ventricle pressure 0.152817765495071 0.324930733948164 0.630341196143309 0.777777777777778 15.1 15 1 increased core body temperature 0.152817765495071 0.324930733948164 0.630341196143309 0.777777777777778 15.1 15 1 decreased bone trabecular spacing 0.152817765495071 0.324930733948164 0.630341196143309 0.777777777777778 15.1 15 1 increased bone mineralization 0.152817765495071 0.324930733948164 0.630341196143309 0.777777777777778 15.1 15 1 weight loss 4.46267826257814e-10 1.09910021565971e-08 0.62982663190156 0.777142857142857 15.1 15 1 circling 1.42244263574475e-05 0.000147123744549483 0.629281799175001 0.776470588235294 15.1 15 1 abnormal enzyme/coenzyme level 0.000340874021000337 0.00240028247566304 0.628788631620789 0.775862068965517 15.1 15 1 increased sarcoma incidence 0.000999736166920722 0.00603602843498858 0.628503466708489 0.775510204081633 15.1 15 1 abnormal female reproductive system morphology 0.00297399300903412 0.0152586888223194 0.628089977585655 0.775 15.1 15 1 increased lung adenoma incidence 0.00903613836194305 0.0369086932271483 0.6274363980044 0.774193548387097 15.1 15 1 abnormal retinal photoreceptor layer morphology 0.00903613836194305 0.0369086932271483 0.6274363980044 0.774193548387097 15.1 15 1 decreased double-negative T cell number 0.00903613836194305 0.0369086932271483 0.6274363980044 0.774193548387097 15.1 15 1 hydronephrosis 2.01643202298593e-05 0.000200234517252594 0.627125169632374 0.773809523809524 15.1 15 1 abnormal placenta development 0.000695269159890095 0.00442096856249974 0.626943130395906 0.773584905660377 15.1 15 1 increased sensitivity to xenobiotic induced morbidity/mortality 1.24049468887067e-06 1.64572295390175e-05 0.626248071493028 0.772727272727273 15.1 15 1 short femur 1.41898678620651e-05 0.000147072067945363 0.626248071493028 0.772727272727273 15.1 15 1 decreased sensitivity to induced morbidity/mortality 0.00205385530493782 0.0111793546412097 0.626248071493028 0.772727272727273 15.1 15 1 abnormal abdominal fat pad morphology 0.0284273420236357 0.0930434385313076 0.626248071493028 0.772727272727273 15.1 15 1 abnormal germ layer development 0.0284273420236357 0.0930434385313076 0.626248071493028 0.772727272727273 15.1 15 1 intestinal inflammation 0.0284273420236357 0.0930434385313076 0.626248071493028 0.772727272727273 15.1 15 1 abnormal retinal outer plexiform layer morphology 0.0284273420236357 0.0930434385313076 0.626248071493028 0.772727272727273 15.1 15 1 abnormal sperm midpiece morphology 0.0284273420236357 0.0930434385313076 0.626248071493028 0.772727272727273 15.1 15 1 failure of palatal shelf elevation 0.0284273420236357 0.0930434385313076 0.626248071493028 0.772727272727273 15.1 15 1 increased adenoma incidence 0.0284273420236357 0.0930434385313076 0.626248071493028 0.772727272727273 15.1 15 1 decreased food intake 4.05708581036414e-05 0.000364332164378368 0.625781766153123 0.772151898734177 15.1 15 1 abnormal blood homeostasis 8.76071840233414e-07 1.18759057361342e-05 0.62560178865351 0.771929824561403 15.1 15 1 increased macrophage cell number 0.000484129891531604 0.00322429211562213 0.62560178865351 0.771929824561403 15.1 15 1 decreased circulating thyroxine level 0.00617419532978246 0.0279750653603531 0.625195553725813 0.771428571428571 15.1 15 1 impaired adaptive thermogenesis 0.00617419532978246 0.0279750653603531 0.625195553725813 0.771428571428571 15.1 15 1 abnormal osteoclast morphology 0.00142141251782702 0.00827079213589406 0.624713149749173 0.770833333333333 15.1 15 1 small ovary 1.40706605962558e-05 0.000146446729009148 0.623414369812064 0.769230769230769 15.1 15 1 absent corpus luteum 0.000985547089095882 0.00599621751106667 0.623414369812064 0.769230769230769 15.1 15 1 increased percent body fat/body weight 0.000985547089095882 0.00599621751106667 0.623414369812064 0.769230769230769 15.1 15 1 decreased body temperature 0.000985547089095882 0.00599621751106667 0.623414369812064 0.769230769230769 15.1 15 1 abnormal circulating hormone level 0.00423473330099643 0.0207974315621493 0.623414369812064 0.769230769230769 15.1 15 1 decreased trabecular bone volume 0.00423473330099643 0.0207974315621493 0.623414369812064 0.769230769230769 15.1 15 1 abnormal kidney cortex morphology 0.0190740463486778 0.0698773052906274 0.623414369812064 0.769230769230769 15.1 15 1 abnormal membranous labyrinth morphology 0.0957340777243899 0.228102029060747 0.623414369812064 0.769230769230769 15.1 15 1 absent trabeculae carneae 0.0957340777243899 0.228102029060747 0.623414369812064 0.769230769230769 15.1 15 1 short hair 0.0957340777243899 0.228102029060747 0.623414369812064 0.769230769230769 15.1 15 1 abnormal intercostal muscle morphology 0.0957340777243899 0.228102029060747 0.623414369812064 0.769230769230769 15.1 15 1 abnormal dopaminergic neuron morphology 0.0957340777243899 0.228102029060747 0.623414369812064 0.769230769230769 15.1 15 1 abnormal GABAergic neuron morphology 0.0957340777243899 0.228102029060747 0.623414369812064 0.769230769230769 15.1 15 1 vestibular hair cell degeneration 0.0957340777243899 0.228102029060747 0.623414369812064 0.769230769230769 15.1 15 1 small interparietal bone 0.0957340777243899 0.228102029060747 0.623414369812064 0.769230769230769 15.1 15 1 increased circulating ammonia level 0.0957340777243899 0.228102029060747 0.623414369812064 0.769230769230769 15.1 15 1 hyperalgesia 0.0957340777243899 0.228102029060747 0.623414369812064 0.769230769230769 15.1 15 1 empty decidua capsularis 0.0957340777243899 0.228102029060747 0.623414369812064 0.769230769230769 15.1 15 1 decreased cardiac stroke volume 0.0957340777243899 0.228102029060747 0.623414369812064 0.769230769230769 15.1 15 1 hyperkeratosis 0.000164502975739558 0.00127675866506131 0.62251087072538 0.768115942028985 15.1 15 1 abnormal food intake 0.000164502975739558 0.00127675866506131 0.62251087072538 0.768115942028985 15.1 15 1 abnormal left-right axis patterning 0.00291371894120022 0.0150059541744007 0.621964568952036 0.767441860465116 15.1 15 1 abnormal blood circulation 0.00291371894120022 0.0150059541744007 0.621964568952036 0.767441860465116 15.1 15 1 increased metastatic potential 0.0128952346952403 0.0507144605603323 0.621336321912691 0.766666666666667 15.1 15 1 abnormal pain threshold 0.0128952346952403 0.0507144605603323 0.621336321912691 0.766666666666667 15.1 15 1 obese 8.04608193590943e-05 0.000675029639648388 0.620985482656952 0.766233766233766 15.1 15 1 decreased circulating alanine transaminase level 0.000231145404158105 0.00171634087415906 0.619747226460229 0.764705882352941 15.1 15 1 abnormal spleen red pulp morphology 0.00876913236620975 0.0361196731139085 0.619747226460229 0.764705882352941 15.1 15 1 increased incidence of corneal inflammation 0.0618514822871399 0.170760890332143 0.619747226460229 0.764705882352941 15.1 15 1 abnormal touch/ nociception 0.0618514822871399 0.170760890332143 0.619747226460229 0.764705882352941 15.1 15 1 decreased growth hormone level 0.0618514822871399 0.170760890332143 0.619747226460229 0.764705882352941 15.1 15 1 pancytopenia 0.0618514822871399 0.170760890332143 0.619747226460229 0.764705882352941 15.1 15 1 abnormal electroretinogram waveform feature 0.0618514822871399 0.170760890332143 0.619747226460229 0.764705882352941 15.1 15 1 abnormal cell cytoskeleton morphology 0.0618514822871399 0.170760890332143 0.619747226460229 0.764705882352941 15.1 15 1 abnormal compact bone morphology 0.00599119706763868 0.0272202789146141 0.618492677418811 0.763157894736842 15.1 15 1 abnormal salivary gland morphology 0.0407121061788009 0.125413454018288 0.617477090099569 0.761904761904762 15.1 15 1 increased incidence of induced tumors 0.0407121061788009 0.125413454018288 0.617477090099569 0.761904761904762 15.1 15 1 increased vasoconstriction 0.0407121061788009 0.125413454018288 0.617477090099569 0.761904761904762 15.1 15 1 increased keratinocyte proliferation 0.0407121061788009 0.125413454018288 0.617477090099569 0.761904761904762 15.1 15 1 abnormal tumor vascularization 0.0407121061788009 0.125413454018288 0.617477090099569 0.761904761904762 15.1 15 1 complete atrioventricular septal defect 0.0407121061788009 0.125413454018288 0.617477090099569 0.761904761904762 15.1 15 1 skin lesions 0.000464694891052151 0.00310316386977779 0.617477090099568 0.761904761904762 15.1 15 1 abnormal lipid homeostasis 5.85881793615281e-07 8.28057364555689e-06 0.617180226113944 0.761538461538461 15.1 15 1 increased T cell number 3.86180915591278e-05 0.000353170966004892 0.617038541029896 0.761363636363636 15.1 15 1 abnormal femur morphology 0.000323475078876914 0.00228917285549452 0.616901085351341 0.761194029850746 15.1 15 1 maternal effect 0.000323475078876914 0.00228917285549452 0.616901085351341 0.761194029850746 15.1 15 1 abnormal digestive system physiology 0.00195029632061476 0.0106506302909533 0.61593339737432 0.76 15.1 15 1 testicular atrophy 0.00195029632061476 0.0106506302909533 0.61593339737432 0.76 15.1 15 1 abnormal inner ear vestibule morphology 0.0271366776269369 0.0930434385313076 0.61593339737432 0.76 15.1 15 1 abnormal keratinocyte physiology 0.0271366776269369 0.0930434385313076 0.61593339737432 0.76 15.1 15 1 polyphagia 0.0013485706821257 0.00788382978093463 0.615333072425612 0.759259259259259 15.1 15 1 increased leukocyte cell number 2.00315513408521e-07 3.0758323432327e-06 0.614815550918105 0.758620689655172 15.1 15 1 dermatitis 0.000934362627487007 0.00572469713269441 0.614815550918105 0.758620689655172 15.1 15 1 glomerulosclerosis 0.000934362627487007 0.00572469713269441 0.614815550918105 0.758620689655172 15.1 15 1 focal hair loss 0.0182532258183041 0.0669688779100759 0.614815550918105 0.758620689655172 15.1 15 1 liver inflammation 2.27794140483567e-06 2.86180769925693e-05 0.614582666239727 0.758333333333333 15.1 15 1 small spleen 3.76125265173782e-05 0.000345244131778518 0.614508450243321 0.758241758241758 15.1 15 1 abnormal skin morphology 0.000450802612584149 0.00301443951291148 0.613968697542185 0.757575757575758 15.1 15 1 increased osteoblast cell number 0.012362895148732 0.0491649906993937 0.613968697542185 0.757575757575758 15.1 15 1 dehydration 0.000313797716811078 0.00225925273680913 0.613617858286446 0.757142857142857 15.1 15 1 increased T cell proliferation 9.09310001706046e-06 9.94245551315951e-05 0.613509655525331 0.757009345794392 15.1 15 1 small seminiferous tubules 0.000218696949652602 0.00162633381841808 0.613304947598896 0.756756756756757 15.1 15 1 abnormal vocalization 0.00841892556168453 0.0357474372408524 0.613304947598896 0.756756756756757 15.1 15 1 Leydig cell hyperplasia 0.00575830765689512 0.0263063182672665 0.612770709839663 0.75609756097561 15.1 15 1 albuminuria 0.00395276313448777 0.0195282985045448 0.612331447682072 0.755555555555556 15.1 15 1 abnormal epidermis stratum corneum morphology 0.00272158126645474 0.0140787598360668 0.611963901795108 0.755102040816326 15.1 15 1 decreased urine osmolality 0.00272158126645474 0.0140787598360668 0.611963901795108 0.755102040816326 15.1 15 1 increased double-negative T cell number 0.000900941167840106 0.00555412925651119 0.61115048056986 0.754098360655738 15.1 15 1 decreased monocyte cell number 0.000625555207136597 0.00403126574547224 0.610946082415823 0.753846153846154 15.1 15 1 spleen hypoplasia 1.73186603383344e-05 0.000174061283198412 0.609758626473324 0.752380952380952 15.1 15 1 abnormal eye electrophysiology 4.20591494709243e-06 4.95839499094427e-05 0.609503470650969 0.752066115702479 15.1 15 1 decreased T cell number 1.25389862972184e-07 2.07247364879274e-06 0.609087455723216 0.751552795031056 15.1 15 1 decreased circulating phosphate level 0.00801695417688334 0.0356747290071508 0.607829010566763 0.75 15.1 15 1 waved hair 0.0576605646483713 0.159811314276126 0.607829010566763 0.75 15.1 15 1 brain inflammation 0.0576605646483713 0.159811314276126 0.607829010566763 0.75 15.1 15 1 abnormal hair texture 0.0576605646483713 0.159811314276126 0.607829010566763 0.75 15.1 15 1 abnormal fibula morphology 0.0576605646483713 0.159811314276126 0.607829010566763 0.75 15.1 15 1 abnormal male reproductive system physiology 0.0576605646483713 0.159811314276126 0.607829010566763 0.75 15.1 15 1 abnormal physiological neovascularization 0.0576605646483713 0.159811314276126 0.607829010566763 0.75 15.1 15 1 enhanced behavioral response to xenobiotic 0.0576605646483713 0.159811314276126 0.607829010566763 0.75 15.1 15 1 abnormal lens morphology 2.85096409251241e-06 3.51949041197252e-05 0.607829010566763 0.75 15.1 15 1 increased food intake 0.000141728870408878 0.00111566634538634 0.607829010566763 0.75 15.1 15 1 abnormal lymph node morphology 0.00377648237819026 0.0188093954523105 0.607829010566763 0.75 15.1 15 1 hypertension 0.00549330984998737 0.0251187651688301 0.607829010566763 0.75 15.1 15 1 abnormal circadian rhythm 0.00549330984998737 0.0251187651688301 0.607829010566763 0.75 15.1 15 1 decreased macrophage cell number 0.00549330984998737 0.0251187651688301 0.607829010566763 0.75 15.1 15 1 abnormal circulating cholesterol level 0.0256140436633342 0.0894244682281317 0.607829010566763 0.75 15.1 15 1 abnormal hormone level 0.0256140436633342 0.0894244682281317 0.607829010566763 0.75 15.1 15 1 abnormal adrenal gland morphology 0.0382328050122629 0.121772218268891 0.607829010566763 0.75 15.1 15 1 decreased metastatic potential 0.0382328050122629 0.121772218268891 0.607829010566763 0.75 15.1 15 1 abnormal primitive streak formation 0.0382328050122629 0.121772218268891 0.607829010566763 0.75 15.1 15 1 decreased ovulation rate 0.0382328050122629 0.121772218268891 0.607829010566763 0.75 15.1 15 1 increased circulating total protein level 0.0382328050122629 0.121772218268891 0.607829010566763 0.75 15.1 15 1 abnormal truncus arteriosus septation 0.0382328050122629 0.121772218268891 0.607829010566763 0.75 15.1 15 1 abnormal mouth morphology 0.0882313483184621 0.223140009374563 0.607829010566763 0.75 15.1 15 1 mixed cellular infiltration to dermis 0.0882313483184621 0.223140009374563 0.607829010566763 0.75 15.1 15 1 abnormal meiosis 0.0882313483184621 0.223140009374563 0.607829010566763 0.75 15.1 15 1 abnormal olfaction 0.0882313483184621 0.223140009374563 0.607829010566763 0.75 15.1 15 1 large intestinal inflammation 0.0882313483184621 0.223140009374563 0.607829010566763 0.75 15.1 15 1 abnormal molar crown morphology 0.0882313483184621 0.223140009374563 0.607829010566763 0.75 15.1 15 1 abnormal level of surface class II molecules 0.0882313483184621 0.223140009374563 0.607829010566763 0.75 15.1 15 1 decreased circulating prolactin level 0.0882313483184621 0.223140009374563 0.607829010566763 0.75 15.1 15 1 blepharitis 0.0882313483184621 0.223140009374563 0.607829010566763 0.75 15.1 15 1 abnormal pulmonary alveolus wall morphology 0.0882313483184621 0.223140009374563 0.607829010566763 0.75 15.1 15 1 abnormal mineral level 0.138011279435592 0.306520587139317 0.607829010566763 0.75 15.1 15 1 abnormal esophagus morphology 0.138011279435592 0.306520587139317 0.607829010566763 0.75 15.1 15 1 amyloidosis 0.138011279435592 0.306520587139317 0.607829010566763 0.75 15.1 15 1 abnormal pilomotor reflex 0.138011279435592 0.306520587139317 0.607829010566763 0.75 15.1 15 1 ear inflammation 0.138011279435592 0.306520587139317 0.607829010566763 0.75 15.1 15 1 increased papilloma incidence 0.138011279435592 0.306520587139317 0.607829010566763 0.75 15.1 15 1 increased growth rate 0.138011279435592 0.306520587139317 0.607829010566763 0.75 15.1 15 1 small intestinal inflammation 0.138011279435592 0.306520587139317 0.607829010566763 0.75 15.1 15 1 absent tail 0.138011279435592 0.306520587139317 0.607829010566763 0.75 15.1 15 1 increased fear-related response 0.138011279435592 0.306520587139317 0.607829010566763 0.75 15.1 15 1 impaired sperm capacitation 0.138011279435592 0.306520587139317 0.607829010566763 0.75 15.1 15 1 delayed somite formation 0.138011279435592 0.306520587139317 0.607829010566763 0.75 15.1 15 1 abnormal nucleotide metabolism 0.138011279435592 0.306520587139317 0.607829010566763 0.75 15.1 15 1 decreased left ventricle systolic pressure 0.138011279435592 0.306520587139317 0.607829010566763 0.75 15.1 15 1 abnormal defecation 0.138011279435592 0.306520587139317 0.607829010566763 0.75 15.1 15 1 vestibular saccular macula degeneration 0.138011279435592 0.306520587139317 0.607829010566763 0.75 15.1 15 1 hemoperitoneum 0.138011279435592 0.306520587139317 0.607829010566763 0.75 15.1 15 1 hydrometra 0.138011279435592 0.306520587139317 0.607829010566763 0.75 15.1 15 1 decreased oligodendrocyte number 0.138011279435592 0.306520587139317 0.607829010566763 0.75 15.1 15 1 abnormal ear pigmentation 0.224150940199866 0.41672306707561 0.607829010566763 0.75 15.1 15 1 abnormal bone marrow development 0.224150940199866 0.41672306707561 0.607829010566763 0.75 15.1 15 1 abnormal esophageal epithelium morphology 0.224150940199866 0.41672306707561 0.607829010566763 0.75 15.1 15 1 abnormal hypoglossal nerve morphology 0.224150940199866 0.41672306707561 0.607829010566763 0.75 15.1 15 1 absent skin pigmentation 0.224150940199866 0.41672306707561 0.607829010566763 0.75 15.1 15 1 abnormal circulating calcium level 0.224150940199866 0.41672306707561 0.607829010566763 0.75 15.1 15 1 abnormal atrial thrombosis 0.224150940199866 0.41672306707561 0.607829010566763 0.75 15.1 15 1 abnormal thyroid physiology 0.224150940199866 0.41672306707561 0.607829010566763 0.75 15.1 15 1 short ureter 0.224150940199866 0.41672306707561 0.607829010566763 0.75 15.1 15 1 altered response to CNS ischemic injury 0.224150940199866 0.41672306707561 0.607829010566763 0.75 15.1 15 1 decreased corneal stroma thickness 0.224150940199866 0.41672306707561 0.607829010566763 0.75 15.1 15 1 decreased susceptibility to age related obesity 0.224150940199866 0.41672306707561 0.607829010566763 0.75 15.1 15 1 abnormal umbilical artery morphology 0.224150940199866 0.41672306707561 0.607829010566763 0.75 15.1 15 1 loss of GABAergic neurons 0.224150940199866 0.41672306707561 0.607829010566763 0.75 15.1 15 1 abnormal perineum morphology 0.224150940199866 0.41672306707561 0.607829010566763 0.75 15.1 15 1 abnormal platelet shape 0.224150940199866 0.41672306707561 0.607829010566763 0.75 15.1 15 1 abnormal gastric gland morphology 0.224150940199866 0.41672306707561 0.607829010566763 0.75 15.1 15 1 abnormal skin development 0.224150940199866 0.41672306707561 0.607829010566763 0.75 15.1 15 1 abnormal miscarriage rate 0.224150940199866 0.41672306707561 0.607829010566763 0.75 15.1 15 1 thin stria vascularis 0.224150940199866 0.41672306707561 0.607829010566763 0.75 15.1 15 1 absent cochlear microphonics 0.224150940199866 0.41672306707561 0.607829010566763 0.75 15.1 15 1 abnormal vestibular labyrinth morphology 0.224150940199866 0.41672306707561 0.607829010566763 0.75 15.1 15 1 increased epididymis weight 0.224150940199866 0.41672306707561 0.607829010566763 0.75 15.1 15 1 ectrodactyly 0.224150940199866 0.41672306707561 0.607829010566763 0.75 15.1 15 1 increased pulmonary ventilation 0.224150940199866 0.41672306707561 0.607829010566763 0.75 15.1 15 1 hypergranulosis 0.224150940199866 0.41672306707561 0.607829010566763 0.75 15.1 15 1 urinary bladder inflammation 0.224150940199866 0.41672306707561 0.607829010566763 0.75 15.1 15 1 impaired behavioral response to alcohol 0.224150940199866 0.41672306707561 0.607829010566763 0.75 15.1 15 1 abnormal base-excision repair 0.224150940199866 0.41672306707561 0.607829010566763 0.75 15.1 15 1 skin fibrosis 0.224150940199866 0.41672306707561 0.607829010566763 0.75 15.1 15 1 abnormal brain ependyma morphology 0.224150940199866 0.41672306707561 0.607829010566763 0.75 15.1 15 1 decreased quadriceps weight 0.224150940199866 0.41672306707561 0.607829010566763 0.75 15.1 15 1 heart right ventricle hypoplasia 0.224150940199866 0.41672306707561 0.607829010566763 0.75 15.1 15 1 myocardial trabeculae hypoplasia 0.224150940199866 0.41672306707561 0.607829010566763 0.75 15.1 15 1 impaired mucociliary clearance 0.224150940199866 0.41672306707561 0.607829010566763 0.75 15.1 15 1 abnormal heart right ventricle pressure 0.224150940199866 0.41672306707561 0.607829010566763 0.75 15.1 15 1 abnormal stomach position or orientation 0.224150940199866 0.41672306707561 0.607829010566763 0.75 15.1 15 1 increased airway resistance 0.224150940199866 0.41672306707561 0.607829010566763 0.75 15.1 15 1 abnormal branching involved in ureteric bud morphogenesis 0.224150940199866 0.41672306707561 0.607829010566763 0.75 15.1 15 1 abnormal macrophage activation involved in immune response 0.224150940199866 0.41672306707561 0.607829010566763 0.75 15.1 15 1 absent Reichert's membrane 0.224150940199866 0.41672306707561 0.607829010566763 0.75 15.1 15 1 abnormal heart echocardiography feature 0.224150940199866 0.41672306707561 0.607829010566763 0.75 15.1 15 1 increased circulating lactate level 0.224150940199866 0.41672306707561 0.607829010566763 0.75 15.1 15 1 increased mammary gland apoptosis 0.224150940199866 0.41672306707561 0.607829010566763 0.75 15.1 15 1 decreased vascular endothelial cell proliferation 0.224150940199866 0.41672306707561 0.607829010566763 0.75 15.1 15 1 abnormal epidermis stratum granulosum morphology 0.0117462300571996 0.0468249154924421 0.607829010566763 0.75 15.1 15 1 increased B cell proliferation 0.00171428743320187 0.00960425673443614 0.604394948360171 0.745762711864407 15.1 15 1 increased circulating calcium level 0.00247741916968651 0.0132671263392792 0.60414519838151 0.745454545454545 15.1 15 1 increased systemic arterial blood pressure 0.00520950769743655 0.0239436890762602 0.60351816652019 0.74468085106383 15.1 15 1 abnormal T-helper 1 physiology 0.00520950769743655 0.0239436890762602 0.60351816652019 0.74468085106383 15.1 15 1 abnormal response/metabolism to endogenous compounds 0.000265824143740376 0.00192500016755221 0.602887311293862 0.74390243902439 15.1 15 1 acanthosis 0.0110849419909012 0.044507757519301 0.602633890818329 0.743589743589744 15.1 15 1 increased vascular permeability 0.0110849419909012 0.044507757519301 0.602633890818329 0.743589743589744 15.1 15 1 decreased B-1 B cell number 0.0110849419909012 0.044507757519301 0.602633890818329 0.743589743589744 15.1 15 1 abnormal response to injury 0.0110849419909012 0.044507757519301 0.602633890818329 0.743589743589744 15.1 15 1 abnormal T cell differentiation 6.06496327672991e-05 0.000524751170464893 0.60181090155125 0.742574257425743 15.1 15 1 increased eosinophil cell number 0.00162668164210558 0.00912372172432383 0.601293214754217 0.741935483870968 15.1 15 1 absent mature ovarian follicles 0.0239901366534699 0.0840851710411075 0.601293214754217 0.741935483870968 15.1 15 1 abnormal small intestine morphology 0.00339339356551878 0.0170182792222338 0.600324948707914 0.740740740740741 15.1 15 1 wrinkled skin 0.0356111967382544 0.113859706794869 0.600324948707914 0.740740740740741 15.1 15 1 abnormal single cell response 0.0356111967382544 0.113859706794869 0.600324948707914 0.740740740740741 15.1 15 1 abnormal bone trabecula morphology 0.0356111967382544 0.113859706794869 0.600324948707914 0.740740740740741 15.1 15 1 kidney inflammation 0.00491677688153772 0.0231418779429046 0.599724623759206 0.74 15.1 15 1 abnormal trabecular bone morphology 1.89886520407596e-05 0.00018969587129072 0.599315999214287 0.739495798319328 15.1 15 1 abnormal lymphocyte physiology 0.00714234144775932 0.0318112342906022 0.599019894471592 0.739130434782609 15.1 15 1 bidirectional circling 0.0533024614821047 0.148643355310242 0.599019894471592 0.739130434782609 15.1 15 1 abnormal circulating insulin level 0.0533024614821047 0.148643355310242 0.599019894471592 0.739130434782609 15.1 15 1 hypotension 0.0533024614821047 0.148643355310242 0.599019894471592 0.739130434782609 15.1 15 1 conjunctivitis 0.0533024614821047 0.148643355310242 0.599019894471592 0.739130434782609 15.1 15 1 increased susceptibility to age related obesity 0.0533024614821047 0.148643355310242 0.599019894471592 0.739130434782609 15.1 15 1 decreased effector memory CD8-positive, alpha-beta T cell number 0.0533024614821047 0.148643355310242 0.599019894471592 0.739130434782609 15.1 15 1 abnormal spleen white pulp morphology 0.0104065091495544 0.0422631698114555 0.598180931033957 0.738095238095238 15.1 15 1 increased neutrophil cell number 2.96066915408984e-06 3.62791355704359e-05 0.598047854074884 0.737931034482759 15.1 15 1 abnormal male meiosis 0.00221564451562009 0.0119165745569837 0.597864600557471 0.737704918032787 15.1 15 1 increased inflammatory response 0.000158963582739822 0.00123956712246177 0.597165343714714 0.736842105263158 15.1 15 1 abnormal retinal outer nuclear layer morphology 0.015216565345013 0.0583824033032945 0.597165343714714 0.736842105263158 15.1 15 1 abnormal triglyceride level 0.0806773026297982 0.209701975226356 0.597165343714714 0.736842105263158 15.1 15 1 lung inflammation 8.02874771772918e-06 8.87622664348948e-05 0.595910794673297 0.735294117647059 15.1 15 1 abnormal vision 0.0223455695446272 0.0804990647969008 0.595910794673297 0.735294117647059 15.1 15 1 decreased regulatory T cell number 0.0223455695446272 0.0804990647969008 0.595910794673297 0.735294117647059 15.1 15 1 decreased osteoclast cell number 0.00972981331761136 0.0395472395875135 0.594321699220835 0.733333333333333 15.1 15 1 abnormal hair cycle 0.0329877014067297 0.105743437176856 0.594321699220835 0.733333333333333 15.1 15 1 arrested T cell differentiation 0.0329877014067297 0.105743437176856 0.594321699220835 0.733333333333333 15.1 15 1 abnormal spleen marginal zone morphology 0.0329877014067297 0.105743437176856 0.594321699220835 0.733333333333333 15.1 15 1 abnormal fat pad morphology 0.0329877014067297 0.105743437176856 0.594321699220835 0.733333333333333 15.1 15 1 decreased chondrocyte number 0.124054831686998 0.278507575651089 0.594321699220835 0.733333333333333 15.1 15 1 hyperpigmentation 0.124054831686998 0.278507575651089 0.594321699220835 0.733333333333333 15.1 15 1 greasy coat 0.124054831686998 0.278507575651089 0.594321699220835 0.733333333333333 15.1 15 1 abnormal Muller cell morphology 0.124054831686998 0.278507575651089 0.594321699220835 0.733333333333333 15.1 15 1 absent chorion 0.124054831686998 0.278507575651089 0.594321699220835 0.733333333333333 15.1 15 1 abnormal aorta wall morphology 0.124054831686998 0.278507575651089 0.594321699220835 0.733333333333333 15.1 15 1 bicuspid aortic valve 0.124054831686998 0.278507575651089 0.594321699220835 0.733333333333333 15.1 15 1 abnormal CD4-positive, alpha-beta T cell physiology 0.0013630466928736 0.0079591048087396 0.59356072393374 0.732394366197183 15.1 15 1 scaly skin 0.0141768992313966 0.0551878510768373 0.593003912748061 0.731707317073171 15.1 15 1 decreased compact bone thickness 0.0019566964541795 0.0106738649775691 0.592708885925799 0.73134328358209 15.1 15 1 abnormal ocular fundus morphology 0.0490209625250692 0.143907289245871 0.592243651321461 0.730769230769231 15.1 15 1 decreased T cell proliferation 6.3886352309953e-06 7.32337794336443e-05 0.591401199470364 0.72972972972973 15.1 15 1 increased insulin secretion 0.0207299521950902 0.0747871734376893 0.591401199470364 0.72972972972973 15.1 15 1 abnormal pancreatic beta cell physiology 0.0207299521950902 0.0747871734376893 0.591401199470364 0.72972972972973 15.1 15 1 abnormal colon morphology 0.00404814045012656 0.0199598599993852 0.590658699533803 0.728813559322034 15.1 15 1 testis hypoplasia 0.0734714772592415 0.191271899196612 0.589409949640497 0.727272727272727 15.1 15 1 abnormal retinal layer morphology 0.0734714772592415 0.191271899196612 0.589409949640497 0.727272727272727 15.1 15 1 abnormal circulating lipid level 0.0734714772592415 0.191271899196612 0.589409949640497 0.727272727272727 15.1 15 1 decreased circulating estradiol level 0.0734714772592415 0.191271899196612 0.589409949640497 0.727272727272727 15.1 15 1 rough coat 0.0734714772592415 0.191271899196612 0.589409949640497 0.727272727272727 15.1 15 1 impaired humoral immune response 0.0734714772592415 0.191271899196612 0.589409949640497 0.727272727272727 15.1 15 1 absent semicircular canals 0.195420694722443 0.37150093857247 0.589409949640497 0.727272727272727 15.1 15 1 abnormal thrombopoiesis 0.195420694722443 0.37150093857247 0.589409949640497 0.727272727272727 15.1 15 1 abnormal awl hair morphology 0.195420694722443 0.37150093857247 0.589409949640497 0.727272727272727 15.1 15 1 abnormal large intestine morphology 0.195420694722443 0.37150093857247 0.589409949640497 0.727272727272727 15.1 15 1 impaired myelopoiesis 0.195420694722443 0.37150093857247 0.589409949640497 0.727272727272727 15.1 15 1 abnormal bronchiole morphology 0.195420694722443 0.37150093857247 0.589409949640497 0.727272727272727 15.1 15 1 retinal detachment 0.195420694722443 0.37150093857247 0.589409949640497 0.727272727272727 15.1 15 1 abnormal nerve fiber response 0.195420694722443 0.37150093857247 0.589409949640497 0.727272727272727 15.1 15 1 abnormal hair medulla 0.195420694722443 0.37150093857247 0.589409949640497 0.727272727272727 15.1 15 1 abnormal Bruch membrane morphology 0.195420694722443 0.37150093857247 0.589409949640497 0.727272727272727 15.1 15 1 abnormal platelet aggregation 0.195420694722443 0.37150093857247 0.589409949640497 0.727272727272727 15.1 15 1 decreased palatine bone horizontal plate size 0.195420694722443 0.37150093857247 0.589409949640497 0.727272727272727 15.1 15 1 increased number of Howell-Jolly bodies 0.195420694722443 0.37150093857247 0.589409949640497 0.727272727272727 15.1 15 1 aberrant origin of the right subclavian artery 0.195420694722443 0.37150093857247 0.589409949640497 0.727272727272727 15.1 15 1 increased pancreatic beta cell proliferation 0.195420694722443 0.37150093857247 0.589409949640497 0.727272727272727 15.1 15 1 decreased embryonic cilium length 0.195420694722443 0.37150093857247 0.589409949640497 0.727272727272727 15.1 15 1 abnormal phrenic nerve innervation pattern to diaphragm 0.195420694722443 0.37150093857247 0.589409949640497 0.727272727272727 15.1 15 1 hypolactation 0.195420694722443 0.37150093857247 0.589409949640497 0.727272727272727 15.1 15 1 abnormal ovarian folliculogenesis 0.0304414896742895 0.097833598920924 0.589409949640497 0.727272727272727 15.1 15 1 decreased systemic arterial blood pressure 0.0304414896742895 0.097833598920924 0.589409949640497 0.727272727272727 15.1 15 1 decreased retinal photoreceptor cell number 0.0449361905065385 0.133149224401447 0.586869389512736 0.724137931034483 15.1 15 1 increased double-positive T cell number 0.0449361905065385 0.133149224401447 0.586869389512736 0.724137931034483 15.1 15 1 polychromatophilia 0.0449361905065385 0.133149224401447 0.586869389512736 0.724137931034483 15.1 15 1 increased retinal apoptosis 0.0449361905065385 0.133149224401447 0.586869389512736 0.724137931034483 15.1 15 1 hepatic necrosis 0.0121974451024497 0.0485458315077499 0.586274790333899 0.723404255319149 15.1 15 1 increased sensitivity to induced morbidity/mortality 1.37623729838093e-06 1.80653840618605e-05 0.585806220328837 0.722826086956522 15.1 15 1 delayed kidney development 0.11138591064791 0.251655270423866 0.585316824990216 0.722222222222222 15.1 15 1 right pulmonary isomerism 0.11138591064791 0.251655270423866 0.585316824990216 0.722222222222222 15.1 15 1 abnormal white adipose tissue morphology 0.11138591064791 0.251655270423866 0.585316824990216 0.722222222222222 15.1 15 1 absent allantois 0.11138591064791 0.251655270423866 0.585316824990216 0.722222222222222 15.1 15 1 abnormal neutrophil morphology 0.11138591064791 0.251655270423866 0.585316824990216 0.722222222222222 15.1 15 1 abnormal macrophage chemotaxis 0.11138591064791 0.251655270423866 0.585316824990216 0.722222222222222 15.1 15 1 impaired leukocyte tethering or rolling 0.11138591064791 0.251655270423866 0.585316824990216 0.722222222222222 15.1 15 1 decreased susceptibility to injury 0.00326388706691843 0.0164851148811362 0.583992578779831 0.720588235294118 15.1 15 1 ruffled hair 0.0667657040031008 0.175562301824453 0.583515850144092 0.72 15.1 15 1 increased pre-B cell number 0.0667657040031008 0.175562301824453 0.583515850144092 0.72 15.1 15 1 decreased placenta weight 0.0667657040031008 0.175562301824453 0.583515850144092 0.72 15.1 15 1 decreased acute inflammation 0.0667657040031008 0.175562301824453 0.583515850144092 0.72 15.1 15 1 abnormal dendritic cell physiology 0.000274860646570576 0.00198466141754516 0.583212882412969 0.719626168224299 15.1 15 1 abnormal urine homeostasis 0.000592858134239139 0.00390658174548307 0.582502801793148 0.71875 15.1 15 1 increased dopamine level 0.0411039657285731 0.126307739036227 0.582502801793148 0.71875 15.1 15 1 increased fatty acid level 0.0411039657285731 0.126307739036227 0.582502801793148 0.71875 15.1 15 1 decreased neutrophil cell number 0.000168631492516533 0.00130068476786008 0.581853411824593 0.717948717948718 15.1 15 1 abnormal leukocyte adhesion 0.0257334247918431 0.0897782526924399 0.581853411824593 0.717948717948718 15.1 15 1 abnormal eye physiology 0.00669254281152716 0.0302410540302885 0.580814387874907 0.716666666666667 15.1 15 1 teratozoospermia 0.00119305792784451 0.00707444957214119 0.580200419177364 0.715909090909091 15.1 15 1 impaired fertilization 0.00399895459323953 0.0197369038704035 0.578884771968345 0.714285714285714 15.1 15 1 abnormal vibrissa morphology 0.0236028744360022 0.0840851710411075 0.578884771968345 0.714285714285714 15.1 15 1 abnormal zigzag hair morphology 0.171620414318993 0.329656973450576 0.578884771968345 0.714285714285714 15.1 15 1 absent visceral yolk sac blood islands 0.171620414318993 0.329656973450576 0.578884771968345 0.714285714285714 15.1 15 1 abnormal adrenal gland secretion 0.171620414318993 0.329656973450576 0.578884771968345 0.714285714285714 15.1 15 1 decreased coping response 0.171620414318993 0.329656973450576 0.578884771968345 0.714285714285714 15.1 15 1 abnormal decidualization 0.171620414318993 0.329656973450576 0.578884771968345 0.714285714285714 15.1 15 1 skeletal muscle necrosis 0.171620414318993 0.329656973450576 0.578884771968345 0.714285714285714 15.1 15 1 abnormal iris pigmentation 0.171620414318993 0.329656973450576 0.578884771968345 0.714285714285714 15.1 15 1 decreased cornea thickness 0.171620414318993 0.329656973450576 0.578884771968345 0.714285714285714 15.1 15 1 abnormal renal reabsorbtion 0.171620414318993 0.329656973450576 0.578884771968345 0.714285714285714 15.1 15 1 abnormal respiratory motile cilium physiology 0.171620414318993 0.329656973450576 0.578884771968345 0.714285714285714 15.1 15 1 failure of atrioventricular cushion closure 0.32101219920621 0.494897951983544 0.578884771968345 0.714285714285714 15.1 15 1 decreased Schwann cell number 0.32101219920621 0.494897951983544 0.578884771968345 0.714285714285714 15.1 15 1 prostate gland epithelial hyperplasia 0.32101219920621 0.494897951983544 0.578884771968345 0.714285714285714 15.1 15 1 abnormal liquid preference 0.32101219920621 0.494897951983544 0.578884771968345 0.714285714285714 15.1 15 1 abnormal circulating free fatty acids level 0.32101219920621 0.494897951983544 0.578884771968345 0.714285714285714 15.1 15 1 abnormal tumor incidence 0.32101219920621 0.494897951983544 0.578884771968345 0.714285714285714 15.1 15 1 increased colonic adenoma incidence 0.32101219920621 0.494897951983544 0.578884771968345 0.714285714285714 15.1 15 1 abnormal adrenal gland physiology 0.32101219920621 0.494897951983544 0.578884771968345 0.714285714285714 15.1 15 1 decreased lateral semicircular canal size 0.32101219920621 0.494897951983544 0.578884771968345 0.714285714285714 15.1 15 1 decreased cholesterol efflux 0.32101219920621 0.494897951983544 0.578884771968345 0.714285714285714 15.1 15 1 calcinosis 0.32101219920621 0.494897951983544 0.578884771968345 0.714285714285714 15.1 15 1 increased muscle weight 0.32101219920621 0.494897951983544 0.578884771968345 0.714285714285714 15.1 15 1 abnormal thyroid gland development 0.32101219920621 0.494897951983544 0.578884771968345 0.714285714285714 15.1 15 1 abnormal prostate gland physiology 0.32101219920621 0.494897951983544 0.578884771968345 0.714285714285714 15.1 15 1 abnormal locus ceruleus morphology 0.32101219920621 0.494897951983544 0.578884771968345 0.714285714285714 15.1 15 1 abnormal hard palate morphology 0.32101219920621 0.494897951983544 0.578884771968345 0.714285714285714 15.1 15 1 absent vestibular hair cells 0.32101219920621 0.494897951983544 0.578884771968345 0.714285714285714 15.1 15 1 utricular macular degeneration 0.32101219920621 0.494897951983544 0.578884771968345 0.714285714285714 15.1 15 1 absent deltoid tuberosity 0.32101219920621 0.494897951983544 0.578884771968345 0.714285714285714 15.1 15 1 increased prostate gland weight 0.32101219920621 0.494897951983544 0.578884771968345 0.714285714285714 15.1 15 1 abnormal ciliary body morphology 0.32101219920621 0.494897951983544 0.578884771968345 0.714285714285714 15.1 15 1 decreased adrenocorticotropin level 0.32101219920621 0.494897951983544 0.578884771968345 0.714285714285714 15.1 15 1 increased adrenocorticotropin level 0.32101219920621 0.494897951983544 0.578884771968345 0.714285714285714 15.1 15 1 increased thyroid-stimulating hormone level 0.32101219920621 0.494897951983544 0.578884771968345 0.714285714285714 15.1 15 1 abnormal thyroid hormone level 0.32101219920621 0.494897951983544 0.578884771968345 0.714285714285714 15.1 15 1 abnormal uterus physiology 0.32101219920621 0.494897951983544 0.578884771968345 0.714285714285714 15.1 15 1 abnormal prostaglandin level 0.32101219920621 0.494897951983544 0.578884771968345 0.714285714285714 15.1 15 1 increased DN3 thymocyte number 0.32101219920621 0.494897951983544 0.578884771968345 0.714285714285714 15.1 15 1 arteritis 0.32101219920621 0.494897951983544 0.578884771968345 0.714285714285714 15.1 15 1 decreased T-helper 17 cell number 0.32101219920621 0.494897951983544 0.578884771968345 0.714285714285714 15.1 15 1 coronary fistula 0.32101219920621 0.494897951983544 0.578884771968345 0.714285714285714 15.1 15 1 dilated pulmonary alveolar ducts 0.32101219920621 0.494897951983544 0.578884771968345 0.714285714285714 15.1 15 1 impaired branching involved in bronchus morphogenesis 0.32101219920621 0.494897951983544 0.578884771968345 0.714285714285714 15.1 15 1 abnormal brain ependyma motile cilium physiology 0.32101219920621 0.494897951983544 0.578884771968345 0.714285714285714 15.1 15 1 parturition failure 0.32101219920621 0.494897951983544 0.578884771968345 0.714285714285714 15.1 15 1 decreased femur compact bone thickness 0.32101219920621 0.494897951983544 0.578884771968345 0.714285714285714 15.1 15 1 abnormal tectorial membrane striated-sheet matrix morphology 0.32101219920621 0.494897951983544 0.578884771968345 0.714285714285714 15.1 15 1 decreased collagen level 0.32101219920621 0.494897951983544 0.578884771968345 0.714285714285714 15.1 15 1 increased abdominal adipose tissue amount 0.32101219920621 0.494897951983544 0.578884771968345 0.714285714285714 15.1 15 1 abnormal leukocyte migration 0.0137764605523637 0.0536710189882609 0.576658292076159 0.711538461538462 15.1 15 1 increased susceptibility to injury 0.0137764605523637 0.0536710189882609 0.576658292076159 0.711538461538462 15.1 15 1 abnormal body temperature homeostasis 0.0549817485813643 0.153068941909506 0.575150031504033 0.709677419354839 15.1 15 1 abnormal T cell proliferation 0.0549817485813643 0.153068941909506 0.575150031504033 0.709677419354839 15.1 15 1 hypopigmentation 0.0899001986231491 0.223140009374563 0.574060732201943 0.708333333333333 15.1 15 1 abnormal cellular extravasation 0.0899001986231491 0.223140009374563 0.574060732201943 0.708333333333333 15.1 15 1 thin skin 0.049871697985479 0.143907289245871 0.572074362886365 0.705882352941177 15.1 15 1 decreased pancreatic beta cell number 0.049871697985479 0.143907289245871 0.572074362886365 0.705882352941177 15.1 15 1 decreased osteoblast cell number 0.049871697985479 0.143907289245871 0.572074362886365 0.705882352941177 15.1 15 1 hydroureter 0.151543026793636 0.324930733948164 0.572074362886365 0.705882352941177 15.1 15 1 abnormal duodenum morphology 0.151543026793636 0.324930733948164 0.572074362886365 0.705882352941177 15.1 15 1 abnormal melanosome morphology 0.151543026793636 0.324930733948164 0.572074362886365 0.705882352941177 15.1 15 1 abnormal tendon morphology 0.151543026793636 0.324930733948164 0.572074362886365 0.705882352941177 15.1 15 1 common atrium 0.151543026793636 0.324930733948164 0.572074362886365 0.705882352941177 15.1 15 1 decreased body fat mass 0.151543026793636 0.324930733948164 0.572074362886365 0.705882352941177 15.1 15 1 abnormal photoreceptor outer segment morphology 0.028486883298731 0.0931770180218191 0.570990888714232 0.704545454545455 15.1 15 1 cryptorchism 0.0808691562687541 0.210090889001071 0.570308701272518 0.703703703703704 15.1 15 1 skin inflammation 0.0452376467474008 0.133962674147809 0.569497451341832 0.702702702702703 15.1 15 1 decreased inflammatory response 0.00346402928043177 0.0173550308863525 0.56923669243554 0.702380952380952 15.1 15 1 decreased IgM level 0.00191520292673754 0.0105516440315828 0.568142580323572 0.701030927835051 15.1 15 1 impaired ovarian folliculogenesis 0.0410404444714461 0.126268528908747 0.567307076528979 0.7 15.1 15 1 abnormal pancreatic beta cell morphology 0.0410404444714461 0.126268528908747 0.567307076528979 0.7 15.1 15 1 decreased skin tensile strength 0.134383024586461 0.301015554848105 0.567307076528979 0.7 15.1 15 1 abnormal thymocyte activation 0.134383024586461 0.301015554848105 0.567307076528979 0.7 15.1 15 1 absent maxillary shelf 0.271014406677752 0.477746874771241 0.567307076528979 0.7 15.1 15 1 absent palatine bone horizontal plate 0.271014406677752 0.477746874771241 0.567307076528979 0.7 15.1 15 1 abnormal epidermis suprabasal layer morphology 0.271014406677752 0.477746874771241 0.567307076528979 0.7 15.1 15 1 abnormal grooming behavior 0.271014406677752 0.477746874771241 0.567307076528979 0.7 15.1 15 1 abnormal immune cell physiology 0.271014406677752 0.477746874771241 0.567307076528979 0.7 15.1 15 1 abnormal neuron specification 0.271014406677752 0.477746874771241 0.567307076528979 0.7 15.1 15 1 abnormal primordial germ cell migration 0.271014406677752 0.477746874771241 0.567307076528979 0.7 15.1 15 1 lymphedema 0.271014406677752 0.477746874771241 0.567307076528979 0.7 15.1 15 1 absent CD4-positive, alpha beta T cells 0.271014406677752 0.477746874771241 0.567307076528979 0.7 15.1 15 1 absent coat pigmentation 0.271014406677752 0.477746874771241 0.567307076528979 0.7 15.1 15 1 tachypnea 0.271014406677752 0.477746874771241 0.567307076528979 0.7 15.1 15 1 decreased thyroxine level 0.271014406677752 0.477746874771241 0.567307076528979 0.7 15.1 15 1 abnormal sperm principal piece morphology 0.271014406677752 0.477746874771241 0.567307076528979 0.7 15.1 15 1 increased T-helper 17 cell number 0.271014406677752 0.477746874771241 0.567307076528979 0.7 15.1 15 1 abnormal heart and great artery attachment 0.271014406677752 0.477746874771241 0.567307076528979 0.7 15.1 15 1 decreased circulating lactate level 0.271014406677752 0.477746874771241 0.567307076528979 0.7 15.1 15 1 gastrointestinal hemorrhage 0.0728159984060922 0.190162515522472 0.567307076528978 0.7 15.1 15 1 delayed wound healing 0.033803189832693 0.108287745922503 0.56378343009091 0.695652173913043 15.1 15 1 abnormal retinal cone cell morphology 0.119572084749841 0.269538342379002 0.56378343009091 0.695652173913043 15.1 15 1 pancreas inflammation 0.119572084749841 0.269538342379002 0.56378343009091 0.695652173913043 15.1 15 1 abnormal inflammatory response 0.00965148289204179 0.0392609381749042 0.562804639413669 0.694444444444444 15.1 15 1 increased autoantibody level 0.0534539294064201 0.148982240222375 0.561072932830858 0.692307692307692 15.1 15 1 small seminal vesicle 0.106691372328672 0.242038110959937 0.561072932830858 0.692307692307692 15.1 15 1 abnormal tectorial membrane morphology 0.106691372328672 0.242038110959937 0.561072932830858 0.692307692307692 15.1 15 1 uterus hypoplasia 0.233134983285798 0.431009491581881 0.561072932830858 0.692307692307692 15.1 15 1 increased pituitary adenoma incidence 0.233134983285798 0.431009491581881 0.561072932830858 0.692307692307692 15.1 15 1 lymphoid hypoplasia 0.233134983285798 0.431009491581881 0.561072932830858 0.692307692307692 15.1 15 1 abnormal otolith morphology 0.233134983285798 0.431009491581881 0.561072932830858 0.692307692307692 15.1 15 1 decreased luteinizing hormone level 0.233134983285798 0.431009491581881 0.561072932830858 0.692307692307692 15.1 15 1 increased circulating thyroxine level 0.233134983285798 0.431009491581881 0.561072932830858 0.692307692307692 15.1 15 1 abnormal hair follicle inner root sheath morphology 0.233134983285798 0.431009491581881 0.561072932830858 0.692307692307692 15.1 15 1 stomach inflammation 0.0954216103567029 0.228102029060747 0.558923228107368 0.689655172413793 15.1 15 1 decreased eosinophil cell number 0.0190295648028429 0.0697657221032746 0.557176593019532 0.6875 15.1 15 1 abnormal kidney physiology 0.0395272070358884 0.12266862059267 0.557176593019532 0.6875 15.1 15 1 delayed hair appearance 0.202866495097775 0.384480309756735 0.557176593019532 0.6875 15.1 15 1 abnormal extraembryonic endoderm formation 0.202866495097775 0.384480309756735 0.557176593019532 0.6875 15.1 15 1 white spotting 0.202866495097775 0.384480309756735 0.557176593019532 0.6875 15.1 15 1 small epididymis 0.202866495097775 0.384480309756735 0.557176593019532 0.6875 15.1 15 1 decreased circulating growth hormone level 0.202866495097775 0.384480309756735 0.557176593019532 0.6875 15.1 15 1 abnormal nail morphology 0.177921228020487 0.340838702118568 0.55451067630652 0.684210526315789 15.1 15 1 short vibrissae 0.177921228020487 0.340838702118568 0.55451067630652 0.684210526315789 15.1 15 1 eyelids fail to open 0.177921228020487 0.340838702118568 0.55451067630652 0.684210526315789 15.1 15 1 decreased liver glycogen level 0.177921228020487 0.340838702118568 0.55451067630652 0.684210526315789 15.1 15 1 abnormal response to infection 0.0118868745655932 0.0473476388821665 0.553970743807683 0.683544303797468 15.1 15 1 increased tumor growth/size 0.0621321979306055 0.1714407569078 0.553470318564857 0.682926829268293 15.1 15 1 abnormal gametogenesis 0.0560006691123441 0.155818416573776 0.552571827787966 0.681818181818182 15.1 15 1 abnormal female reproductive system physiology 0.156946497028845 0.324930733948164 0.552571827787966 0.681818181818182 15.1 15 1 increased susceptibility to bacterial infection induced morbidity/mortality 0.0181384249141159 0.0665967999614217 0.551548546625396 0.680555555555556 15.1 15 1 abnormal feces composition 0.139060999690752 0.308714178251446 0.551098302913865 0.68 15.1 15 1 corneal vascularization 0.123650985159953 0.278480602612388 0.549940533369928 0.678571428571429 15.1 15 1 autoimmune response 0.110267923038021 0.249923880234239 0.54900684825385 0.67741935483871 15.1 15 1 abnormal CD8-positive, alpha beta T cell morphology 0.110267923038021 0.249923880234239 0.54900684825385 0.67741935483871 15.1 15 1 decreased cytotoxic T cell cytolysis 0.0985719462318582 0.234638962920332 0.548237931099433 0.676470588235294 15.1 15 1 increased susceptibility to viral infection induced morbidity/mortality 0.0985719462318582 0.234638962920332 0.548237931099433 0.676470588235294 15.1 15 1 increased B cell number 0.00447370965255789 0.0216926954400346 0.547219280168368 0.675213675213675 15.1 15 1 abnormal skin pigmentation 0.0792357827329044 0.206062738680711 0.547046109510087 0.675 15.1 15 1 increased susceptibility to weight loss 0.0792357827329044 0.206062738680711 0.547046109510087 0.675 15.1 15 1 decreased IgA level 0.0520930644780081 0.14576096500455 0.545487573585556 0.673076923076923 15.1 15 1 abnormal humoral immune response 0.0112074221303878 0.0447128509211544 0.540292453837122 0.666666666666667 15.1 15 1 abnormal cytotoxic T cell physiology 0.0897925758374963 0.223140009374563 0.540292453837122 0.666666666666667 15.1 15 1 small lens 0.100141514911333 0.237623848428959 0.540292453837122 0.666666666666667 15.1 15 1 curly vibrissae 0.178915857003223 0.342612158811022 0.540292453837122 0.666666666666667 15.1 15 1 increased bone ossification 0.203085652114787 0.384749093401016 0.540292453837122 0.666666666666667 15.1 15 1 increased litter size 0.310239525296145 0.484141040887178 0.540292453837122 0.666666666666667 15.1 15 1 abnormal tracheal ciliated epithelium morphology 0.310239525296145 0.484141040887178 0.540292453837122 0.666666666666667 15.1 15 1 increased circulating parathyroid hormone level 0.310239525296145 0.484141040887178 0.540292453837122 0.666666666666667 15.1 15 1 decreased circulating ketone body level 0.310239525296145 0.484141040887178 0.540292453837122 0.666666666666667 15.1 15 1 absent cochlear hair cells 0.310239525296145 0.484141040887178 0.540292453837122 0.666666666666667 15.1 15 1 abnormal B cell proliferation 0.310239525296145 0.484141040887178 0.540292453837122 0.666666666666667 15.1 15 1 decreased renal glomerular filtration rate 0.310239525296145 0.484141040887178 0.540292453837122 0.666666666666667 15.1 15 1 abnormal aorta elastic tissue morphology 0.310239525296145 0.484141040887178 0.540292453837122 0.666666666666667 15.1 15 1 decreased compensatory feeding amount 0.310239525296145 0.484141040887178 0.540292453837122 0.666666666666667 15.1 15 1 abnormal colon goblet cell morphology 0.310239525296145 0.484141040887178 0.540292453837122 0.666666666666667 15.1 15 1 abnormal systemic arterial blood pressure 0.111889507738825 0.25244911610007 0.540292453837122 0.666666666666667 15.1 15 1 head tilt 0.111889507738825 0.25244911610007 0.540292453837122 0.666666666666667 15.1 15 1 absent vibrissae 0.125283291265665 0.280885251936315 0.540292453837122 0.666666666666667 15.1 15 1 diarrhea 0.125283291265665 0.280885251936315 0.540292453837122 0.666666666666667 15.1 15 1 abnormal estrous cycle 0.140632834257924 0.31192525654622 0.540292453837122 0.666666666666667 15.1 15 1 abnormal stomach glandular epithelium morphology 0.231857259085087 0.429765225017999 0.540292453837122 0.666666666666667 15.1 15 1 thick dermal layer 0.231857259085087 0.429765225017999 0.540292453837122 0.666666666666667 15.1 15 1 abnormal Peyer's patch follicle morphology 0.231857259085087 0.429765225017999 0.540292453837122 0.666666666666667 15.1 15 1 increased susceptibility to autoimmune disorder 0.231857259085087 0.429765225017999 0.540292453837122 0.666666666666667 15.1 15 1 abnormal sperm axoneme morphology 0.231857259085087 0.429765225017999 0.540292453837122 0.666666666666667 15.1 15 1 decreased fluid intake 0.231857259085087 0.429765225017999 0.540292453837122 0.666666666666667 15.1 15 1 vagina atresia 0.266751579582985 0.477370182886816 0.540292453837122 0.666666666666667 15.1 15 1 joint inflammation 0.266751579582985 0.477370182886816 0.540292453837122 0.666666666666667 15.1 15 1 abnormal ear development 0.266751579582985 0.477370182886816 0.540292453837122 0.666666666666667 15.1 15 1 thick tail 0.366817289609455 0.559961956369143 0.540292453837122 0.666666666666667 15.1 15 1 dilated uterus 0.366817289609455 0.559961956369143 0.540292453837122 0.666666666666667 15.1 15 1 abnormal vagina epithelium morphology 0.366817289609455 0.559961956369143 0.540292453837122 0.666666666666667 15.1 15 1 abnormal lens vesicle development 0.366817289609455 0.559961956369143 0.540292453837122 0.666666666666667 15.1 15 1 multifocal hepatic necrosis 0.366817289609455 0.559961956369143 0.540292453837122 0.666666666666667 15.1 15 1 long gestation period 0.366817289609455 0.559961956369143 0.540292453837122 0.666666666666667 15.1 15 1 priapism 0.366817289609455 0.559961956369143 0.540292453837122 0.666666666666667 15.1 15 1 decreased susceptibility to induced choroidal neovascularization 0.366817289609455 0.559961956369143 0.540292453837122 0.666666666666667 15.1 15 1 absent cochlear outer hair cells 0.366817289609455 0.559961956369143 0.540292453837122 0.666666666666667 15.1 15 1 decreased cochlear hair cell number 0.366817289609455 0.559961956369143 0.540292453837122 0.666666666666667 15.1 15 1 abnormal hair cell mechanoelectric transduction 0.366817289609455 0.559961956369143 0.540292453837122 0.666666666666667 15.1 15 1 decreased thyroid-stimulating hormone level 0.366817289609455 0.559961956369143 0.540292453837122 0.666666666666667 15.1 15 1 increased stomach mucosa thickness 0.366817289609455 0.559961956369143 0.540292453837122 0.666666666666667 15.1 15 1 increased tidal volume 0.366817289609455 0.559961956369143 0.540292453837122 0.666666666666667 15.1 15 1 multiflagellated sperm 0.366817289609455 0.559961956369143 0.540292453837122 0.666666666666667 15.1 15 1 abnormal incisor color 0.366817289609455 0.559961956369143 0.540292453837122 0.666666666666667 15.1 15 1 prolonged RR interval 0.366817289609455 0.559961956369143 0.540292453837122 0.666666666666667 15.1 15 1 decreased susceptibility to parasitic infection induced morbidity/mortality 0.366817289609455 0.559961956369143 0.540292453837122 0.666666666666667 15.1 15 1 abnormal pulmonary alveolar parenchyma morphology 0.366817289609455 0.559961956369143 0.540292453837122 0.666666666666667 15.1 15 1 decreased pancreatic beta cell proliferation 0.366817289609455 0.559961956369143 0.540292453837122 0.666666666666667 15.1 15 1 abnormal cytokine secretion 0.00349990878248222 0.0175171490873733 0.536784061279738 0.662337662337662 15.1 15 1 abnormal immune system physiology 0.00875728475806951 0.0361196731139085 0.535935256628758 0.661290322580645 15.1 15 1 decreased IgG level 0.0154863385353362 0.0583824033032945 0.532991204460945 0.657657657657658 15.1 15 1 abnormal intestinal goblet cell morphology 0.140367963110467 0.311476635358864 0.532573990210878 0.657142857142857 15.1 15 1 abnormal NK cell physiology 0.0661891244782593 0.175562301824453 0.53143520049553 0.655737704918033 15.1 15 1 abnormal circulating glucose level 0.177286797286127 0.340147248938868 0.530977066702 0.655172413793103 15.1 15 1 decreased granulocyte number 0.177286797286127 0.340147248938868 0.530977066702 0.655172413793103 15.1 15 1 abnormal stomach morphology 0.20020362915246 0.380157654592935 0.529902214340255 0.653846153846154 15.1 15 1 decreased Peyer's patch number 0.20020362915246 0.380157654592935 0.529902214340255 0.653846153846154 15.1 15 1 abnormal immune system morphology 0.111678185462951 0.252201077021417 0.528546965710229 0.652173913043478 15.1 15 1 decreased epididymis weight 0.227023520051978 0.421748324219041 0.528546965710229 0.652173913043478 15.1 15 1 increased susceptibility to fungal infection 0.227023520051978 0.421748324219041 0.528546965710229 0.652173913043478 15.1 15 1 impaired macrophage phagocytosis 0.124473442081797 0.279321323571014 0.527727513050213 0.651162790697674 15.1 15 1 abnormal T cell activation 0.0594865717940799 0.164780453605539 0.525689955084768 0.648648648648649 15.1 15 1 abnormal skin physiology 0.17425409049431 0.334586684758469 0.524401499312501 0.647058823529412 15.1 15 1 abnormal hair shaft morphology 0.122902887003727 0.276921133534212 0.523408314654712 0.645833333333333 15.1 15 1 abnormal intestine physiology 0.195841763748657 0.372159195817253 0.522863665003667 0.645161290322581 15.1 15 1 increased circulating luteinizing hormone level 0.220768479167902 0.41672306707561 0.520996294771511 0.642857142857143 15.1 15 1 abnormal vasoconstriction 0.343861207426045 0.528649415001413 0.520996294771511 0.642857142857143 15.1 15 1 abnormal antigen presentation 0.343861207426045 0.528649415001413 0.520996294771511 0.642857142857143 15.1 15 1 abnormal kidney medulla morphology 0.343861207426045 0.528649415001413 0.520996294771511 0.642857142857143 15.1 15 1 abnormal imprinting 0.343861207426045 0.528649415001413 0.520996294771511 0.642857142857143 15.1 15 1 abnormal pancreas development 0.343861207426045 0.528649415001413 0.520996294771511 0.642857142857143 15.1 15 1 increased B-1 B cell number 0.343861207426045 0.528649415001413 0.520996294771511 0.642857142857143 15.1 15 1 impaired conditioned place preference behavior 0.249768936669838 0.461418663175805 0.518680755683638 0.64 15.1 15 1 increased activated T cell number 0.283829173515187 0.477746874771241 0.515733705935435 0.636363636363636 15.1 15 1 decreased susceptibility to viral infection induced morbidity/mortality 0.283829173515187 0.477746874771241 0.515733705935435 0.636363636363636 15.1 15 1 abnormal primary sex determination 0.403303402599543 0.589607530982288 0.515733705935435 0.636363636363636 15.1 15 1 abnormal larynx morphology 0.403303402599543 0.589607530982288 0.515733705935435 0.636363636363636 15.1 15 1 variable body spotting 0.403303402599543 0.589607530982288 0.515733705935435 0.636363636363636 15.1 15 1 patent ductus arteriosus 0.403303402599543 0.589607530982288 0.515733705935435 0.636363636363636 15.1 15 1 allodynia 0.403303402599543 0.589607530982288 0.515733705935435 0.636363636363636 15.1 15 1 abnormal frequency of paradoxical sleep 0.403303402599543 0.589607530982288 0.515733705935435 0.636363636363636 15.1 15 1 enlarged placenta 0.403303402599543 0.589607530982288 0.515733705935435 0.636363636363636 15.1 15 1 increased motor neuron number 0.403303402599543 0.589607530982288 0.515733705935435 0.636363636363636 15.1 15 1 abnormal extraembryonic ectoderm morphology 0.403303402599543 0.589607530982288 0.515733705935435 0.636363636363636 15.1 15 1 decreased colon length 0.403303402599543 0.589607530982288 0.515733705935435 0.636363636363636 15.1 15 1 abnormal T cell subpopulation ratio 0.213955052587352 0.404724861833489 0.515733705935435 0.636363636363636 15.1 15 1 salivary gland inflammation 0.240598187971205 0.444641896417811 0.513277831145266 0.633333333333333 15.1 15 1 flaky skin 0.324319026624402 0.499686329345432 0.511856008898326 0.631578947368421 15.1 15 1 decreased grooming behavior 0.324319026624402 0.499686329345432 0.511856008898326 0.631578947368421 15.1 15 1 abnormal intestinal epithelium morphology 0.19324736429216 0.369913673471911 0.506524175472302 0.625 15.1 15 1 small lymph nodes 0.30720295846657 0.480910861664943 0.506524175472302 0.625 15.1 15 1 abnormal crypts of Lieberkuhn morphology 0.259698756479895 0.465484360699364 0.506524175472302 0.625 15.1 15 1 abnormal epididymis epithelium morphology 0.373226720391669 0.568351066406046 0.506524175472302 0.625 15.1 15 1 increased thymus weight 0.373226720391669 0.568351066406046 0.506524175472302 0.625 15.1 15 1 abnormal wound healing 0.373226720391669 0.568351066406046 0.506524175472302 0.625 15.1 15 1 sepsis 0.373226720391669 0.568351066406046 0.506524175472302 0.625 15.1 15 1 abnormal Langerhans cell physiology 0.373226720391669 0.568351066406046 0.506524175472302 0.625 15.1 15 1 decreased circulating triiodothyronine level 0.373226720391669 0.568351066406046 0.506524175472302 0.625 15.1 15 1 absent pre-B cells 0.482447630883451 0.645362324282571 0.506524175472302 0.625 15.1 15 1 enlarged pituitary gland 0.482447630883451 0.645362324282571 0.506524175472302 0.625 15.1 15 1 unidirectional circling 0.482447630883451 0.645362324282571 0.506524175472302 0.625 15.1 15 1 abnormal secondary sex determination 0.482447630883451 0.645362324282571 0.506524175472302 0.625 15.1 15 1 coarse hair 0.482447630883451 0.645362324282571 0.506524175472302 0.625 15.1 15 1 head spot 0.482447630883451 0.645362324282571 0.506524175472302 0.625 15.1 15 1 abnormal soft palate morphology 0.482447630883451 0.645362324282571 0.506524175472302 0.625 15.1 15 1 urinary incontinence 0.482447630883451 0.645362324282571 0.506524175472302 0.625 15.1 15 1 hair follicle degeneration 0.482447630883451 0.645362324282571 0.506524175472302 0.625 15.1 15 1 pulmonary interstitial fibrosis 0.482447630883451 0.645362324282571 0.506524175472302 0.625 15.1 15 1 abnormal thermosensation 0.482447630883451 0.645362324282571 0.506524175472302 0.625 15.1 15 1 abnormal hair follicle melanocyte morphology 0.482447630883451 0.645362324282571 0.506524175472302 0.625 15.1 15 1 abnormal optic choroid morphology 0.482447630883451 0.645362324282571 0.506524175472302 0.625 15.1 15 1 increased circulating prolactin level 0.482447630883451 0.645362324282571 0.506524175472302 0.625 15.1 15 1 abnormal circulating corticosterone level 0.482447630883451 0.645362324282571 0.506524175472302 0.625 15.1 15 1 abnormal mast cell differentiation 0.482447630883451 0.645362324282571 0.506524175472302 0.625 15.1 15 1 enlarged inguinal lymph nodes 0.482447630883451 0.645362324282571 0.506524175472302 0.625 15.1 15 1 abnormal sensory neuron physiology 0.482447630883451 0.645362324282571 0.506524175472302 0.625 15.1 15 1 decreased serotonin level 0.482447630883451 0.645362324282571 0.506524175472302 0.625 15.1 15 1 abnormal lateral plate mesoderm morphology 0.482447630883451 0.645362324282571 0.506524175472302 0.625 15.1 15 1 abnormal pulmonary acinus morphology 0.482447630883451 0.645362324282571 0.506524175472302 0.625 15.1 15 1 decreased surfactant secretion 0.482447630883451 0.645362324282571 0.506524175472302 0.625 15.1 15 1 increased circulating ferritin level 0.482447630883451 0.645362324282571 0.506524175472302 0.625 15.1 15 1 small thymus medulla 0.482447630883451 0.645362324282571 0.506524175472302 0.625 15.1 15 1 abnormal CD8-positive, alpha-beta T cell physiology 0.29192032224717 0.477746874771241 0.503030905296631 0.620689655172414 15.1 15 1 dry skin 0.349277780608125 0.536645138519277 0.501700135705899 0.619047619047619 15.1 15 1 decreased cochlear outer hair cell number 0.349277780608125 0.536645138519277 0.501700135705899 0.619047619047619 15.1 15 1 abnormal lens fiber morphology 0.265439438659421 0.475535184490681 0.498731495849651 0.615384615384615 15.1 15 1 abnormal leukocyte cell number 0.329073428697643 0.506854584449155 0.498731495849651 0.615384615384615 15.1 15 1 abnormal mast cell morphology 0.433606792512702 0.631866957454802 0.498731495849651 0.615384615384615 15.1 15 1 abnormal renal/urinary system morphology 0.433606792512702 0.631866957454802 0.498731495849651 0.615384615384615 15.1 15 1 decreased alcohol consumption 0.433606792512702 0.631866957454802 0.498731495849651 0.615384615384615 15.1 15 1 increased circulating thyroid-stimulating hormone level 0.433606792512702 0.631866957454802 0.498731495849651 0.615384615384615 15.1 15 1 small pituitary gland 0.433606792512702 0.631866957454802 0.498731495849651 0.615384615384615 15.1 15 1 increased renin activity 0.433606792512702 0.631866957454802 0.498731495849651 0.615384615384615 15.1 15 1 decreased susceptibility to induced arthritis 0.211299691693569 0.399853923992205 0.497637786428929 0.614035087719298 15.1 15 1 impaired natural killer cell mediated cytotoxicity 0.211299691693569 0.399853923992205 0.497637786428929 0.614035087719298 15.1 15 1 abnormal retinal rod cell morphology 0.399263073694369 0.585421099802383 0.495268082684029 0.611111111111111 15.1 15 1 abnormal iron level 0.399263073694369 0.585421099802383 0.495268082684029 0.611111111111111 15.1 15 1 decreased activity of thyroid 0.399263073694369 0.585421099802383 0.495268082684029 0.611111111111111 15.1 15 1 abnormal B cell morphology 0.372193523346845 0.567820539297931 0.493310501329547 0.608695652173913 15.1 15 1 abnormal lens development 0.372193523346845 0.567820539297931 0.493310501329547 0.608695652173913 15.1 15 1 abnormal thrombosis 0.256824913130906 0.465484360699364 0.492619590263259 0.607843137254902 15.1 15 1 decreased circulating progesterone level 0.349595084211162 0.536966824313224 0.492052056173094 0.607142857142857 15.1 15 1 abnormal Peyer's patch T cell area morphology 0.422630729249775 0.617318813275876 0.48626320845341 0.6 15.1 15 1 increased urine calcium level 0.422630729249775 0.617318813275876 0.48626320845341 0.6 15.1 15 1 abnormal lateral semicircular canal morphology 0.510521614007008 0.645362324282571 0.48626320845341 0.6 15.1 15 1 abnormal pituitary secretion 0.510521614007008 0.645362324282571 0.48626320845341 0.6 15.1 15 1 decreased circulating parathyroid hormone level 0.510521614007008 0.645362324282571 0.48626320845341 0.6 15.1 15 1 primary sex reversal 0.510521614007008 0.645362324282571 0.48626320845341 0.6 15.1 15 1 abnormal bone healing 0.510521614007008 0.645362324282571 0.48626320845341 0.6 15.1 15 1 delayed dark adaptation 0.510521614007008 0.645362324282571 0.48626320845341 0.6 15.1 15 1 rickets 0.510521614007008 0.645362324282571 0.48626320845341 0.6 15.1 15 1 abnormal scala media morphology 0.510521614007008 0.645362324282571 0.48626320845341 0.6 15.1 15 1 decreased prolactin level 0.510521614007008 0.645362324282571 0.48626320845341 0.6 15.1 15 1 absent inguinal lymph nodes 0.510521614007008 0.645362324282571 0.48626320845341 0.6 15.1 15 1 crystalluria 0.510521614007008 0.645362324282571 0.48626320845341 0.6 15.1 15 1 increased serotonin level 0.510521614007008 0.645362324282571 0.48626320845341 0.6 15.1 15 1 increased susceptibility to parasitic infection 0.211121222643882 0.399820358832628 0.48626320845341 0.6 15.1 15 1 abnormal T-helper 2 physiology 0.283759237857528 0.477746874771241 0.48626320845341 0.6 15.1 15 1 arthritis 0.459525649190634 0.645362324282571 0.48626320845341 0.6 15.1 15 1 lactation failure 0.459525649190634 0.645362324282571 0.48626320845341 0.6 15.1 15 1 abnormal retinal photoreceptor morphology 0.404339842083815 0.590949093527315 0.476728635738637 0.588235294117647 15.1 15 1 enlarged sebaceous gland 0.482179863348295 0.645362324282571 0.476728635738637 0.588235294117647 15.1 15 1 nephrocalcinosis 0.482179863348295 0.645362324282571 0.476728635738637 0.588235294117647 15.1 15 1 increased susceptibility to induced arthritis 0.431300996993484 0.629613397899819 0.475084743891263 0.586206896551724 15.1 15 1 enlarged epididymis 0.431300996993484 0.629613397899819 0.475084743891263 0.586206896551724 15.1 15 1 increased placenta weight 0.533592830824301 0.645362324282571 0.472755897107482 0.583333333333333 15.1 15 1 abnormal anogenital distance 0.533592830824301 0.645362324282571 0.472755897107482 0.583333333333333 15.1 15 1 altered susceptibility to infection 0.502311138415573 0.645362324282571 0.469201341490133 0.578947368421053 15.1 15 1 abnormal spleen germinal center morphology 0.497522849389539 0.645362324282571 0.463107817574676 0.571428571428571 15.1 15 1 abnormal bile salt homeostasis 0.520434660771975 0.645362324282571 0.463107817574676 0.571428571428571 15.1 15 1 abnormal spleen periarteriolar lymphoid sheath morphology 0.553267572628245 0.646279918719305 0.463107817574676 0.571428571428571 15.1 15 1 abnormal intestinal absorption 0.570481414789303 0.653958371509926 0.455871757925072 0.5625 15.1 15 1 abnormal urinary bladder physiology 0.570481414789303 0.653958371509926 0.455871757925072 0.5625 15.1 15 1 abnormal stomach mucosa morphology 0.552050179837943 0.645362324282571 0.453845661223183 0.56 15.1 15 1 abnormal lung volume 0.626985557475948 0.697351475171661 0.450243711530935 0.555555555555556 15.1 15 1 abnormal taste sensitivity 0.626985557475948 0.697351475171661 0.450243711530935 0.555555555555556 15.1 15 1 yellow coat color 0.626985557475948 0.697351475171661 0.450243711530935 0.555555555555556 15.1 15 1 abnormal lens capsule morphology 0.626985557475948 0.697351475171661 0.450243711530935 0.555555555555556 15.1 15 1 impaired febrile response 0.626985557475948 0.697351475171661 0.450243711530935 0.555555555555556 15.1 15 1 increased circulating progesterone level 0.626985557475948 0.697351475171661 0.450243711530935 0.555555555555556 15.1 15 1 absent cervical lymph nodes 0.626985557475948 0.697351475171661 0.450243711530935 0.555555555555556 15.1 15 1 decreased bone mineral density of femur 0.626985557475948 0.697351475171661 0.450243711530935 0.555555555555556 15.1 15 1 intestinal ulcer 0.61237866467417 0.68333350084692 0.442057462230373 0.545454545454545 15.1 15 1 increased mast cell number 0.639183467695966 0.710283169932417 0.442057462230373 0.545454545454545 15.1 15 1 secondary sex reversal 0.639183467695966 0.710283169932417 0.442057462230373 0.545454545454545 15.1 15 1 rectal hemorrhage 0.639183467695966 0.710283169932417 0.442057462230373 0.545454545454545 15.1 15 1 abnormal lymph circulation 0.639183467695966 0.710283169932417 0.442057462230373 0.545454545454545 15.1 15 1 increased circulating adrenocorticotropin level 0.650243208854498 0.72225049431818 0.436390058868445 0.538461538461538 15.1 15 1 decreased follicle stimulating hormone level 0.650243208854498 0.72225049431818 0.436390058868445 0.538461538461538 15.1 15 1 abnormal intestinal mucosa morphology 0.65095416555251 0.722878788755299 0.433490457148389 0.534883720930233 15.1 15 1 decreased susceptibility to parasitic infection 0.663584324018316 0.736740016065861 0.430545549151457 0.53125 15.1 15 1 abnormal circulating chemokine level 0.669820660160437 0.743497943841627 0.429055772164774 0.529411764705882 15.1 15 1 hypoalgesia 0.686888314015747 0.762272889187673 0.424515499443453 0.523809523809524 15.1 15 1 abnormal regulatory T cell physiology 0.694694882196423 0.770764281651919 0.422837572568183 0.521739130434783 15.1 15 1 increased natural killer cell mediated cytotoxicity 0.743449500944889 0.822847565885268 0.405219340377842 0.5 15.1 15 1 intestinal edema 0.743449500944889 0.822847565885268 0.405219340377842 0.5 15.1 15 1 increased defecation amount 0.743449500944889 0.822847565885268 0.405219340377842 0.5 15.1 15 1 absent axillary lymph nodes 0.743449500944889 0.822847565885268 0.405219340377842 0.5 15.1 15 1 abnormal hair cuticle 0.747218845080751 0.825086406108487 0.405219340377842 0.5 15.1 15 1 abnormal pituitary gland morphology 0.750320984038871 0.82621666569132 0.405219340377842 0.5 15.1 15 1 increased circulating estradiol level 0.750320984038871 0.82621666569132 0.405219340377842 0.5 15.1 15 1 abnormal pancreatic alpha cell morphology 0.750320984038871 0.82621666569132 0.405219340377842 0.5 15.1 15 1 abnormal fertilization 0.750320984038871 0.82621666569132 0.405219340377842 0.5 15.1 15 1 decreased susceptibility to bacterial infection induced morbidity/mortality 0.828484850075073 0.871766524772311 0.39214774875275 0.483870967741935 15.1 15 1 shortened PR interval 0.830337861985657 0.87334690557688 0.368381218525311 0.454545454545455 15.1 15 1 abnormal dendritic cell chemotaxis 0.830337861985657 0.87334690557688 0.368381218525311 0.454545454545455 15.1 15 1 decreased airway responsiveness 0.872083596423166 0.913970063662366 0.368381218525311 0.454545454545455 15.1 15 1 abnormal circulating cytokine level 0.873813955271809 0.915397857965309 0.364697406340058 0.45 15.1 15 1 nuclear cataracts 0.873813955271809 0.915397857965309 0.364697406340058 0.45 15.1 15 1 increased urine phosphate level 0.891454831569961 0.93368163938117 0.337682783648202 0.416666666666667 15.1 15 1 abnormal gut flora balance 0.932488734671525 0.966687112938287 0.311707184906032 0.384615384615385 15.1 15 1 abnormal intestinal lipid absorption 0.953321698474738 0.987666690943736 0.303914505283381 0.375 15.1 15 1 anencephaly 1.63472112854301e-08 4.64727863685799e-07 1.44991694951975 1 15.2 15 2 alcohol preference 0.000128129999958965 0.00140406773082787 1.44991694951975 1 15.2 15 2 ketoaciduria 0.000128129999958965 0.00140406773082787 1.44991694951975 1 15.2 15 2 increased fatty acid oxidation 0.000128129999958965 0.00140406773082787 1.44991694951975 1 15.2 15 2 abnormal circulating HDL cholesterol level 0.0113255041066748 0.0541252477720531 1.44991694951975 1 15.2 15 2 optic nerve atrophy 0.0113255041066748 0.0541252477720531 1.44991694951975 1 15.2 15 2 decreased sensitivity to skin irradiation 0.0113255041066748 0.0541252477720531 1.44991694951975 1 15.2 15 2 abnormal oropharynx morphology 0.0113255041066748 0.0541252477720531 1.44991694951975 1 15.2 15 2 improved righting response 0.0113255041066748 0.0541252477720531 1.44991694951975 1 15.2 15 2 enhanced NMDA-mediated synaptic currents 0.0113255041066748 0.0541252477720531 1.44991694951975 1 15.2 15 2 thyroid hypoplasia 0.0113255041066748 0.0541252477720531 1.44991694951975 1 15.2 15 2 absent uterus 0.0113255041066748 0.0541252477720531 1.44991694951975 1 15.2 15 2 scapular bone foramen 0.0113255041066748 0.0541252477720531 1.44991694951975 1 15.2 15 2 absent frontal bone 0.0113255041066748 0.0541252477720531 1.44991694951975 1 15.2 15 2 abnormal calcaneum morphology 0.0113255041066748 0.0541252477720531 1.44991694951975 1 15.2 15 2 enlarged eye anterior chamber 0.0113255041066748 0.0541252477720531 1.44991694951975 1 15.2 15 2 abnormal olfactory bulb granule cell layer morphology 0.0113255041066748 0.0541252477720531 1.44991694951975 1 15.2 15 2 abnormal cerebellum lobule morphology 0.0113255041066748 0.0541252477720531 1.44991694951975 1 15.2 15 2 increased T follicular helper cell number 0.0113255041066748 0.0541252477720531 1.44991694951975 1 15.2 15 2 abnormal lymphatic vessel endothelial cell morphology 0.0113255041066748 0.0541252477720531 1.44991694951975 1 15.2 15 2 increased thyroid carcinoma incidence 0.0113255041066748 0.0541252477720531 1.44991694951975 1 15.2 15 2 decreased QRS amplitude 0.0113255041066748 0.0541252477720531 1.44991694951975 1 15.2 15 2 aorta hypoplasia 0.0113255041066748 0.0541252477720531 1.44991694951975 1 15.2 15 2 fused right lung lobes 0.0113255041066748 0.0541252477720531 1.44991694951975 1 15.2 15 2 abnormal lung alveolus development 0.0113255041066748 0.0541252477720531 1.44991694951975 1 15.2 15 2 abnormal circadian regulation of heart rate 0.0113255041066748 0.0541252477720531 1.44991694951975 1 15.2 15 2 impaired branching involved in terminal bronchiole morphogenesis 0.0113255041066748 0.0541252477720531 1.44991694951975 1 15.2 15 2 blind ureter 0.0113255041066748 0.0541252477720531 1.44991694951975 1 15.2 15 2 delayed optic fissure closure 0.0113255041066748 0.0541252477720531 1.44991694951975 1 15.2 15 2 abnormal mitophagy 0.0113255041066748 0.0541252477720531 1.44991694951975 1 15.2 15 2 decreased small intestinal villus height 0.0113255041066748 0.0541252477720531 1.44991694951975 1 15.2 15 2 decreased neuronal precursor proliferation 0.0113255041066748 0.0541252477720531 1.44991694951975 1 15.2 15 2 decreased platelet alpha-granule number 0.0113255041066748 0.0541252477720531 1.44991694951975 1 15.2 15 2 abnormal proximal-distal axis patterning 5.22773724548035e-05 0.000635892244407451 1.44991694951975 1 15.2 15 2 abnormal fear/anxiety-related behavior 5.22773724548035e-05 0.000635892244407451 1.44991694951975 1 15.2 15 2 abnormal NMDA-mediated synaptic currents 0.000314028685403116 0.00306331903898137 1.44991694951975 1 15.2 15 2 enhanced conditioned place preference behavior 0.000314028685403116 0.00306331903898137 1.44991694951975 1 15.2 15 2 increased cardiac muscle glycogen level 0.000314028685403116 0.00306331903898137 1.44991694951975 1 15.2 15 2 decreased aerobic running capacity 0.00076960740618051 0.0065674045381613 1.44991694951975 1 15.2 15 2 colon polyps 0.00076960740618051 0.0065674045381613 1.44991694951975 1 15.2 15 2 abnormal lateral ganglionic eminence morphology 0.00076960740618051 0.0065674045381613 1.44991694951975 1 15.2 15 2 impaired behavioral response to alcohol 0.00076960740618051 0.0065674045381613 1.44991694951975 1 15.2 15 2 abnormal hepatic vein morphology 0.00076960740618051 0.0065674045381613 1.44991694951975 1 15.2 15 2 abnormal anterior commissure pars posterior morphology 0.00076960740618051 0.0065674045381613 1.44991694951975 1 15.2 15 2 retropleural edema 0.00076960740618051 0.0065674045381613 1.44991694951975 1 15.2 15 2 broad head 0.00188603861238615 0.013921427443058 1.44991694951975 1 15.2 15 2 maxilla hypoplasia 0.00188603861238615 0.013921427443058 1.44991694951975 1 15.2 15 2 limp posture 0.00188603861238615 0.013921427443058 1.44991694951975 1 15.2 15 2 abnormal inhibitory postsynaptic potential 0.00188603861238615 0.013921427443058 1.44991694951975 1 15.2 15 2 aorta coarctation 0.00188603861238615 0.013921427443058 1.44991694951975 1 15.2 15 2 abnormal Purkinje cell innervation 0.00188603861238615 0.013921427443058 1.44991694951975 1 15.2 15 2 abnormal optic tract morphology 0.00188603861238615 0.013921427443058 1.44991694951975 1 15.2 15 2 abnormal talus morphology 0.00188603861238615 0.013921427443058 1.44991694951975 1 15.2 15 2 abnormal retina inner limiting membrane morphology 0.00188603861238615 0.013921427443058 1.44991694951975 1 15.2 15 2 abnormal outer hair cell kinocilium morphology 0.00188603861238615 0.013921427443058 1.44991694951975 1 15.2 15 2 decreased femur compact bone thickness 0.00188603861238615 0.013921427443058 1.44991694951975 1 15.2 15 2 abnormal AMPA-mediated synaptic currents 2.13283910383824e-05 0.000287557575652987 1.44991694951975 1 15.2 15 2 decreased synaptic depression 2.13283910383824e-05 0.000287557575652987 1.44991694951975 1 15.2 15 2 abnormal urethra morphology 0.00462182339823088 0.0275702295038353 1.44991694951975 1 15.2 15 2 thin tail 0.00462182339823088 0.0275702295038353 1.44991694951975 1 15.2 15 2 abnormal avoidance learning behavior 0.00462182339823088 0.0275702295038353 1.44991694951975 1 15.2 15 2 absent ectoplacental cone 0.00462182339823088 0.0275702295038353 1.44991694951975 1 15.2 15 2 delayed brain development 0.00462182339823088 0.0275702295038353 1.44991694951975 1 15.2 15 2 chromatolysis 0.00462182339823088 0.0275702295038353 1.44991694951975 1 15.2 15 2 abnormal hippocampal fimbria morphology 0.00462182339823088 0.0275702295038353 1.44991694951975 1 15.2 15 2 abnormal intestinal peristalsis 0.00462182339823088 0.0275702295038353 1.44991694951975 1 15.2 15 2 decreased liver function 0.00462182339823088 0.0275702295038353 1.44991694951975 1 15.2 15 2 increased glycerol level 0.00462182339823088 0.0275702295038353 1.44991694951975 1 15.2 15 2 absent parietal bone 0.00462182339823088 0.0275702295038353 1.44991694951975 1 15.2 15 2 abnormal common crus morphology 0.00462182339823088 0.0275702295038353 1.44991694951975 1 15.2 15 2 abnormal dermis papillary layer morphology 0.00462182339823088 0.0275702295038353 1.44991694951975 1 15.2 15 2 decreased platelet ADP level 0.00462182339823088 0.0275702295038353 1.44991694951975 1 15.2 15 2 absent sperm mitochondrial sheath 0.00462182339823088 0.0275702295038353 1.44991694951975 1 15.2 15 2 abnormal olfactory bulb layer morphology 0.00462182339823088 0.0275702295038353 1.44991694951975 1 15.2 15 2 ectopic hippocampus pyramidal cells 0.00462182339823088 0.0275702295038353 1.44991694951975 1 15.2 15 2 abnormal intestinal enteroendocrine cell morphology 0.00462182339823088 0.0275702295038353 1.44991694951975 1 15.2 15 2 absent long term depression 2.19722554796504e-10 8.28120992509552e-09 1.39991981332942 0.96551724137931 15.2 15 2 decreased paired-pulse facilitation 4.91040530605042e-07 1.01788609990004e-05 1.37742110204376 0.95 15.2 15 2 spleen atrophy 4.91040530605042e-07 1.01788609990004e-05 1.37742110204376 0.95 15.2 15 2 abnormal postnatal subventricular zone morphology 4.91040530605042e-07 1.01788609990004e-05 1.37742110204376 0.95 15.2 15 2 abnormal brain wave pattern 3.89549806375863e-16 3.02814107299987e-14 1.36626789473977 0.942307692307692 15.2 15 2 abnormal interatrial septum morphology 6.18652867069752e-06 0.000100581634433726 1.36462771719506 0.941176470588235 15.2 15 2 increased brain size 6.18652867069752e-06 0.000100581634433726 1.36462771719506 0.941176470588235 15.2 15 2 increased cochlear outer hair cell number 1.43084438188716e-05 0.000208141836254053 1.35929714017477 0.9375 15.2 15 2 abnormal synaptic transmission 1.99946390903086e-09 6.37649547912085e-08 1.35325581955177 0.933333333333333 15.2 15 2 abnormal pup retrieval 3.29729077938962e-05 0.000422784062563488 1.35325581955177 0.933333333333333 15.2 15 2 delayed intramembranous bone ossification 3.29729077938962e-05 0.000422784062563488 1.35325581955177 0.933333333333333 15.2 15 2 testis degeneration 7.56720853034505e-05 0.000877549240989898 1.34635145312548 0.928571428571429 15.2 15 2 abnormal excitatory postsynaptic currents 1.01560527970792e-21 1.62988266662803e-19 1.33838487647977 0.923076923076923 15.2 15 2 increased synaptic depression 0.00017285355270774 0.0018066101359685 1.33838487647977 0.923076923076923 15.2 15 2 axonal dystrophy 0.00017285355270774 0.0018066101359685 1.33838487647977 0.923076923076923 15.2 15 2 abnormal nest building behavior 1.235334222947e-07 2.89895649017043e-06 1.33392359355817 0.92 15.2 15 2 reduced long term depression 2.21974391775635e-10 8.30317743672018e-09 1.32909053705977 0.916666666666667 15.2 15 2 abnormal corticospinal tract morphology 0.000392716168035437 0.0037003085908642 1.32909053705977 0.916666666666667 15.2 15 2 abnormal vascular endothelial cell development 0.000392716168035437 0.0037003085908642 1.32909053705977 0.916666666666667 15.2 15 2 abnormal somatic nervous system physiology 0.000392716168035437 0.0037003085908642 1.32909053705977 0.916666666666667 15.2 15 2 reduced cerebellar foliation 0.000392716168035437 0.0037003085908642 1.32909053705977 0.916666666666667 15.2 15 2 impaired synaptic plasticity 1.12375529656713e-09 3.80318544246359e-08 1.32198310103271 0.911764705882353 15.2 15 2 social withdrawal 0.000886656275000588 0.00740119961095289 1.31810631774523 0.909090909090909 15.2 15 2 abnormal hypothalamus secretion 0.000886656275000588 0.00740119961095289 1.31810631774523 0.909090909090909 15.2 15 2 abnormal spinal cord ventral horn morphology 0.000886656275000588 0.00740119961095289 1.31810631774523 0.909090909090909 15.2 15 2 aorta dilation 0.000886656275000588 0.00740119961095289 1.31810631774523 0.909090909090909 15.2 15 2 enhanced paired-pulse facilitation 2.78520743911256e-08 7.65547348595856e-07 1.30492525456778 0.9 15.2 15 2 increased mammary adenocarcinoma incidence 7.03775101200466e-06 0.000111151781856264 1.30492525456778 0.9 15.2 15 2 increased heart rate variability 0.00198711685440047 0.0146025204588513 1.30492525456778 0.9 15.2 15 2 protruding tongue 0.00198711685440047 0.0146025204588513 1.30492525456778 0.9 15.2 15 2 abnormal hippocampus neuron morphology 0.00198711685440047 0.0146025204588513 1.30492525456778 0.9 15.2 15 2 increased mortality induced by gamma-irradiation 6.1646211757149e-08 1.5568015405676e-06 1.29992554094874 0.896551724137931 15.2 15 2 abnormal long term depression 1.55903679044622e-05 0.00022287954116293 1.2972941127282 0.894736842105263 15.2 15 2 abnormal cochlear inner hair cell morphology 1.55903679044622e-05 0.00022287954116293 1.2972941127282 0.894736842105263 15.2 15 2 abnormal behavioral response to xenobiotic 1.55903679044622e-05 0.00022287954116293 1.2972941127282 0.894736842105263 15.2 15 2 abnormal nervous system electrophysiology 2.10126186820101e-20 2.82534534981082e-18 1.29456870492835 0.892857142857143 15.2 15 2 increased pheochromocytoma incidence 0.00441423717239966 0.0272129243279905 1.28881506623978 0.888888888888889 15.2 15 2 abnormal vomeronasal organ morphology 0.00441423717239966 0.0272129243279905 1.28881506623978 0.888888888888889 15.2 15 2 enlarged otoliths 0.00441423717239966 0.0272129243279905 1.28881506623978 0.888888888888889 15.2 15 2 premature bone ossification 0.00441423717239966 0.0272129243279905 1.28881506623978 0.888888888888889 15.2 15 2 decreased fear-related response 0.00441423717239966 0.0272129243279905 1.28881506623978 0.888888888888889 15.2 15 2 decreased cellular sensitivity to ionizing radiation 0.00441423717239966 0.0272129243279905 1.28881506623978 0.888888888888889 15.2 15 2 abnormal proprioceptive neuron morphology 0.00441423717239966 0.0272129243279905 1.28881506623978 0.888888888888889 15.2 15 2 decreased vestibular hair cell number 0.00441423717239966 0.0272129243279905 1.28881506623978 0.888888888888889 15.2 15 2 decreased cochlear hair cell number 0.00441423717239966 0.0272129243279905 1.28881506623978 0.888888888888889 15.2 15 2 increased neuronal precursor cell number 0.00441423717239966 0.0272129243279905 1.28881506623978 0.888888888888889 15.2 15 2 abnormal CNS synapse formation 0.00441423717239966 0.0272129243279905 1.28881506623978 0.888888888888889 15.2 15 2 abnormal intervertebral disk development 0.00441423717239966 0.0272129243279905 1.28881506623978 0.888888888888889 15.2 15 2 increased tidal volume 0.00441423717239966 0.0272129243279905 1.28881506623978 0.888888888888889 15.2 15 2 abnormal optic chiasm morphology 0.00441423717239966 0.0272129243279905 1.28881506623978 0.888888888888889 15.2 15 2 abnormal hippocampus granule cell morphology 0.00441423717239966 0.0272129243279905 1.28881506623978 0.888888888888889 15.2 15 2 retropulsion 0.00441423717239966 0.0272129243279905 1.28881506623978 0.888888888888889 15.2 15 2 abnormal lung lobe morphology 0.00441423717239966 0.0272129243279905 1.28881506623978 0.888888888888889 15.2 15 2 reduced AMPA-mediated synaptic currents 0.00441423717239966 0.0272129243279905 1.28881506623978 0.888888888888889 15.2 15 2 trigeminal neuroma 0.00441423717239966 0.0272129243279905 1.28881506623978 0.888888888888889 15.2 15 2 cerebellum atrophy 0.00441423717239966 0.0272129243279905 1.28881506623978 0.888888888888889 15.2 15 2 abnormal inhibitory postsynaptic currents 5.13601405679125e-16 3.93102614346715e-14 1.27933848487037 0.882352941176471 15.2 15 2 abnormal touch/ nociception 7.52228074301767e-05 0.000875951299192676 1.27933848487037 0.882352941176471 15.2 15 2 abnormal glutamate-mediated receptor currents 7.52228074301767e-05 0.000875951299192676 1.27933848487037 0.882352941176471 15.2 15 2 abnormal axon extension 5.47369220710424e-12 2.83662695107746e-10 1.27592691557738 0.88 15.2 15 2 abnormal long term potentiation 6.09261531994371e-08 1.54646740901633e-06 1.26867733082978 0.875 15.2 15 2 abnormal impulse conducting system conduction 3.08149511750527e-06 5.37910112617148e-05 1.26867733082978 0.875 15.2 15 2 decreased aggression towards mice 0.00016362415561907 0.00173567201323 1.26867733082978 0.875 15.2 15 2 loose skin 0.00016362415561907 0.00173567201323 1.26867733082978 0.875 15.2 15 2 abnormal ear pigmentation 0.00970105705582567 0.0493484241847983 1.26867733082978 0.875 15.2 15 2 abnormal exoccipital bone morphology 0.00970105705582567 0.0493484241847983 1.26867733082978 0.875 15.2 15 2 absent mammary gland 0.00970105705582567 0.0493484241847983 1.26867733082978 0.875 15.2 15 2 increased sensitivity to skin irradiation 0.00970105705582567 0.0493484241847983 1.26867733082978 0.875 15.2 15 2 absent eyelids 0.00970105705582567 0.0493484241847983 1.26867733082978 0.875 15.2 15 2 short ureter 0.00970105705582567 0.0493484241847983 1.26867733082978 0.875 15.2 15 2 early eyelid opening 0.00970105705582567 0.0493484241847983 1.26867733082978 0.875 15.2 15 2 abnormal neuron apoptosis 0.00970105705582567 0.0493484241847983 1.26867733082978 0.875 15.2 15 2 abnormal eyelid aperture 0.00970105705582567 0.0493484241847983 1.26867733082978 0.875 15.2 15 2 binucleate 0.00970105705582567 0.0493484241847983 1.26867733082978 0.875 15.2 15 2 abnormal gastric gland morphology 0.00970105705582567 0.0493484241847983 1.26867733082978 0.875 15.2 15 2 tau protein deposits 0.00970105705582567 0.0493484241847983 1.26867733082978 0.875 15.2 15 2 absent interparietal bone 0.00970105705582567 0.0493484241847983 1.26867733082978 0.875 15.2 15 2 abnormal kidney epithelium morphology 0.00970105705582567 0.0493484241847983 1.26867733082978 0.875 15.2 15 2 accumulation of giant lysosomes in kidney/renal tubule cells 0.00970105705582567 0.0493484241847983 1.26867733082978 0.875 15.2 15 2 abnormal somite size 0.00970105705582567 0.0493484241847983 1.26867733082978 0.875 15.2 15 2 craniofacial phenotype 0.00970105705582567 0.0493484241847983 1.26867733082978 0.875 15.2 15 2 abnormal base-excision repair 0.00970105705582567 0.0493484241847983 1.26867733082978 0.875 15.2 15 2 abnormal olfactory bulb glomerular layer morphology 0.00970105705582567 0.0493484241847983 1.26867733082978 0.875 15.2 15 2 abnormal olfactory bulb mitral cell layer morphology 0.00970105705582567 0.0493484241847983 1.26867733082978 0.875 15.2 15 2 decreased hippocampus pyramidal cell number 0.00970105705582567 0.0493484241847983 1.26867733082978 0.875 15.2 15 2 abnormal cerebellum deep nucleus morphology 0.00970105705582567 0.0493484241847983 1.26867733082978 0.875 15.2 15 2 increased caudal vertebrae number 0.00970105705582567 0.0493484241847983 1.26867733082978 0.875 15.2 15 2 abnormal brain ependyma morphology 0.00970105705582567 0.0493484241847983 1.26867733082978 0.875 15.2 15 2 abnormal circulating serum amyloid protein level 0.00970105705582567 0.0493484241847983 1.26867733082978 0.875 15.2 15 2 pleural effusion 0.00970105705582567 0.0493484241847983 1.26867733082978 0.875 15.2 15 2 abnormal visual evoked potential 0.00970105705582567 0.0493484241847983 1.26867733082978 0.875 15.2 15 2 abnormal stomach position or orientation 0.00970105705582567 0.0493484241847983 1.26867733082978 0.875 15.2 15 2 decreased alveolar lamellar body number 0.00970105705582567 0.0493484241847983 1.26867733082978 0.875 15.2 15 2 absent ureteric bud 0.00970105705582567 0.0493484241847983 1.26867733082978 0.875 15.2 15 2 increased aorta wall thickness 0.00970105705582567 0.0493484241847983 1.26867733082978 0.875 15.2 15 2 impaired neuron differentiation 0.00970105705582567 0.0493484241847983 1.26867733082978 0.875 15.2 15 2 absent hypoglossal canal 0.00970105705582567 0.0493484241847983 1.26867733082978 0.875 15.2 15 2 abnormal contextual conditioning behavior 1.14993190361787e-12 6.50103547783968e-11 1.26538206503542 0.872727272727273 15.2 15 2 abnormal basicranium morphology 6.64109201195964e-06 0.000105557293161339 1.26079734740848 0.869565217391304 15.2 15 2 abnormal CNS synaptic transmission 2.2645048352423e-21 3.41391259252437e-19 1.25952381473433 0.868686868686869 15.2 15 2 delayed eyelid opening 2.81308104636303e-07 6.24780277038217e-06 1.25659468958378 0.866666666666667 15.2 15 2 macrocytosis 0.000353216739115553 0.00337933322519207 1.25659468958378 0.866666666666667 15.2 15 2 abnormal seizure response to electrical stimulation 0.000353216739115553 0.00337933322519207 1.25659468958378 0.866666666666667 15.2 15 2 increased alcohol consumption 0.000353216739115553 0.00337933322519207 1.25659468958378 0.866666666666667 15.2 15 2 abnormal rostral migratory stream morphology 0.000353216739115553 0.00337933322519207 1.25659468958378 0.866666666666667 15.2 15 2 abnormal olfactory nerve morphology 0.000353216739115553 0.00337933322519207 1.25659468958378 0.866666666666667 15.2 15 2 abnormal zygomatic bone morphology 0.000353216739115553 0.00337933322519207 1.25659468958378 0.866666666666667 15.2 15 2 abnormal channel response 1.42295951322132e-05 0.000207601864465575 1.25220100185797 0.863636363636364 15.2 15 2 abnormal occipital bone morphology 1.42295951322132e-05 0.000207601864465575 1.25220100185797 0.863636363636364 15.2 15 2 abnormal lung development 9.76702977829874e-18 1.07979940326747e-15 1.24522279194049 0.858823529411765 15.2 15 2 reduced long term potentiation 9.12710337329828e-23 1.51357797607197e-20 1.24278595673122 0.857142857142857 15.2 15 2 abnormal scapula morphology 3.02961062941125e-05 0.000393532973402636 1.24278595673122 0.857142857142857 15.2 15 2 abnormal embryonic/fetal subventricular zone morphology 3.02961062941125e-05 0.000393532973402636 1.24278595673122 0.857142857142857 15.2 15 2 megacephaly 0.000755942357133474 0.00652918962975527 1.24278595673122 0.857142857142857 15.2 15 2 abnormal placing response 0.000755942357133474 0.00652918962975527 1.24278595673122 0.857142857142857 15.2 15 2 decreased CNS synapse formation 0.000755942357133474 0.00652918962975527 1.24278595673122 0.857142857142857 15.2 15 2 increased circulating growth hormone level 0.000755942357133474 0.00652918962975527 1.24278595673122 0.857142857142857 15.2 15 2 sternebra fusion 0.000755942357133474 0.00652918962975527 1.24278595673122 0.857142857142857 15.2 15 2 pulmonary alveolar hemorrhage 0.000755942357133474 0.00652918962975527 1.24278595673122 0.857142857142857 15.2 15 2 abnormal vitelline vein topology 0.000755942357133474 0.00652918962975527 1.24278595673122 0.857142857142857 15.2 15 2 failure of atrioventricular cushion closure 0.0210365321132992 0.0889182219742257 1.24278595673122 0.857142857142857 15.2 15 2 polyphalangy 0.0210365321132992 0.0889182219742257 1.24278595673122 0.857142857142857 15.2 15 2 abnormal oculomotor nerve morphology 0.0210365321132992 0.0889182219742257 1.24278595673122 0.857142857142857 15.2 15 2 retina hyperplasia 0.0210365321132992 0.0889182219742257 1.24278595673122 0.857142857142857 15.2 15 2 excessive tearing 0.0210365321132992 0.0889182219742257 1.24278595673122 0.857142857142857 15.2 15 2 abnormal axial mesoderm 0.0210365321132992 0.0889182219742257 1.24278595673122 0.857142857142857 15.2 15 2 increased chemically-elicited antinociception 0.0210365321132992 0.0889182219742257 1.24278595673122 0.857142857142857 15.2 15 2 abnormal tumor incidence 0.0210365321132992 0.0889182219742257 1.24278595673122 0.857142857142857 15.2 15 2 abnormal gastrulation movements 0.0210365321132992 0.0889182219742257 1.24278595673122 0.857142857142857 15.2 15 2 absent tunnel of Corti 0.0210365321132992 0.0889182219742257 1.24278595673122 0.857142857142857 15.2 15 2 decreased cardiomyocyte apoptosis 0.0210365321132992 0.0889182219742257 1.24278595673122 0.857142857142857 15.2 15 2 abnormal sinus venosus morphology 0.0210365321132992 0.0889182219742257 1.24278595673122 0.857142857142857 15.2 15 2 abnormal central pattern generator function 0.0210365321132992 0.0889182219742257 1.24278595673122 0.857142857142857 15.2 15 2 abnormal cochlear nerve compound action potential 0.0210365321132992 0.0889182219742257 1.24278595673122 0.857142857142857 15.2 15 2 absent fibula 0.0210365321132992 0.0889182219742257 1.24278595673122 0.857142857142857 15.2 15 2 abnormal body temperature 0.0210365321132992 0.0889182219742257 1.24278595673122 0.857142857142857 15.2 15 2 heart hemorrhage 0.0210365321132992 0.0889182219742257 1.24278595673122 0.857142857142857 15.2 15 2 enhanced behavioral response to alcohol 0.0210365321132992 0.0889182219742257 1.24278595673122 0.857142857142857 15.2 15 2 decreased behavioral withdrawal response 0.0210365321132992 0.0889182219742257 1.24278595673122 0.857142857142857 15.2 15 2 decreased skeletal muscle glycogen level 0.0210365321132992 0.0889182219742257 1.24278595673122 0.857142857142857 15.2 15 2 heart block 0.0210365321132992 0.0889182219742257 1.24278595673122 0.857142857142857 15.2 15 2 increased compact bone volume 0.0210365321132992 0.0889182219742257 1.24278595673122 0.857142857142857 15.2 15 2 embryonic lethality at implantation, incomplete penetrance 0.0210365321132992 0.0889182219742257 1.24278595673122 0.857142857142857 15.2 15 2 ductus venosus stenosis 0.0210365321132992 0.0889182219742257 1.24278595673122 0.857142857142857 15.2 15 2 vertebral transformation 2.27609169693274e-10 8.45041506883612e-09 1.23847072771479 0.854166666666667 15.2 15 2 abnormal direction of heart looping 1.16312361169616e-07 2.75549522294685e-06 1.23669386870802 0.852941176470588 15.2 15 2 decreased susceptibility to pharmacologically induced seizures 2.69186743460007e-06 4.74895052735297e-05 1.23511443847979 0.851851851851852 15.2 15 2 abnormal incus morphology 6.40551969617216e-05 0.000756946804951461 1.23242940709179 0.85 15.2 15 2 increased skin tumor incidence 6.40551969617216e-05 0.000756946804951461 1.23242940709179 0.85 15.2 15 2 abnormal locomotor coordination 2.44330781986916e-07 5.45087731114307e-06 1.23023256322888 0.848484848484849 15.2 15 2 abnormal nasal bone morphology 5.65192113614052e-06 9.27996952221093e-05 1.22685280343979 0.846153846153846 15.2 15 2 excessive scratching 0.00160196055233777 0.0122415948238266 1.22685280343979 0.846153846153846 15.2 15 2 abnormal afterhyperpolarization 0.00160196055233777 0.0122415948238266 1.22685280343979 0.846153846153846 15.2 15 2 abnormal retinal inner plexiform layer morphology 0.00160196055233777 0.0122415948238266 1.22685280343979 0.846153846153846 15.2 15 2 increased cochlear inner hair cell number 0.00160196055233777 0.0122415948238266 1.22685280343979 0.846153846153846 15.2 15 2 abnormal vertebral arch development 0.00160196055233777 0.0122415948238266 1.22685280343979 0.846153846153846 15.2 15 2 absent hypoglossal nerve 0.00160196055233777 0.0122415948238266 1.22685280343979 0.846153846153846 15.2 15 2 trabecula carnea hypoplasia 2.0917561936252e-09 6.62833570909896e-08 1.22437431292779 0.844444444444444 15.2 15 2 abnormal dendritic spine morphology 1.95964495061549e-10 7.4994104840862e-09 1.22247899665391 0.843137254901961 15.2 15 2 maternal imprinting 0.000134395951679054 0.00145986868909016 1.22098269433242 0.842105263157895 15.2 15 2 abnormal object recognition memory 1.06184858538745e-06 2.01629645507732e-05 1.21605937701657 0.838709677419355 15.2 15 2 abnormal vocalization 9.72194945005343e-08 2.38259598591211e-06 1.21479528203006 0.837837837837838 15.2 15 2 abnormal maxilla morphology 1.62774743826947e-10 6.47843480431249e-09 1.20826412459979 0.833333333333333 15.2 15 2 abnormal pharyngeal arch morphology 2.00677947410886e-07 4.64359436450771e-06 1.20826412459979 0.833333333333333 15.2 15 2 delayed kidney development 0.00027959112313144 0.00276533963733383 1.20826412459979 0.833333333333333 15.2 15 2 absent ureter 0.00027959112313144 0.00276533963733383 1.20826412459979 0.833333333333333 15.2 15 2 abnormal eye anterior chamber morphology 0.00027959112313144 0.00276533963733383 1.20826412459979 0.833333333333333 15.2 15 2 decreased pulmonary respiratory rate 0.00027959112313144 0.00276533963733383 1.20826412459979 0.833333333333333 15.2 15 2 thymus atrophy 1.73275087266453e-09 5.59768544902988e-08 1.20826412459979 0.833333333333333 15.2 15 2 ocular hypertelorism 2.44390764842314e-05 0.00032422508135747 1.20826412459979 0.833333333333333 15.2 15 2 increased stereotypic behavior 2.44390764842314e-05 0.00032422508135747 1.20826412459979 0.833333333333333 15.2 15 2 abnormal mating frequency 0.00335635680982634 0.0218272877501778 1.20826412459979 0.833333333333333 15.2 15 2 abnormal thymus involution 0.00335635680982634 0.0218272877501778 1.20826412459979 0.833333333333333 15.2 15 2 abnormal respiratory function 0.00335635680982634 0.0218272877501778 1.20826412459979 0.833333333333333 15.2 15 2 absent ovary 0.00335635680982634 0.0218272877501778 1.20826412459979 0.833333333333333 15.2 15 2 increased osteosarcoma incidence 0.00335635680982634 0.0218272877501778 1.20826412459979 0.833333333333333 15.2 15 2 stria vascularis degeneration 0.00335635680982634 0.0218272877501778 1.20826412459979 0.833333333333333 15.2 15 2 abnormal fatty acid level 0.00335635680982634 0.0218272877501778 1.20826412459979 0.833333333333333 15.2 15 2 abnormal behavioral response to addictive substance 0.00335635680982634 0.0218272877501778 1.20826412459979 0.833333333333333 15.2 15 2 decreased red blood cell distribution width 0.00335635680982634 0.0218272877501778 1.20826412459979 0.833333333333333 15.2 15 2 prenatal growth retardation 0.00335635680982634 0.0218272877501778 1.20826412459979 0.833333333333333 15.2 15 2 embryonic lethality between implantation and placentation, incomplete penetrance 0.00335635680982634 0.0218272877501778 1.20826412459979 0.833333333333333 15.2 15 2 abnormal lacrimal gland physiology 0.0448439076488947 0.152389645186647 1.20826412459979 0.833333333333333 15.2 15 2 hyperresponsive 0.0448439076488947 0.152389645186647 1.20826412459979 0.833333333333333 15.2 15 2 jumpy 0.0448439076488947 0.152389645186647 1.20826412459979 0.833333333333333 15.2 15 2 non-obstructive hydrocephaly 0.0448439076488947 0.152389645186647 1.20826412459979 0.833333333333333 15.2 15 2 reduced NMDA-mediated synaptic currents 0.0448439076488947 0.152389645186647 1.20826412459979 0.833333333333333 15.2 15 2 abnormal chemically-elicited antinociception 0.0448439076488947 0.152389645186647 1.20826412459979 0.833333333333333 15.2 15 2 abnormal parental behavior 0.0448439076488947 0.152389645186647 1.20826412459979 0.833333333333333 15.2 15 2 abnormal internal nares morphology 0.0448439076488947 0.152389645186647 1.20826412459979 0.833333333333333 15.2 15 2 abnormal pulmonary ventilation 0.0448439076488947 0.152389645186647 1.20826412459979 0.833333333333333 15.2 15 2 increased post-tetanic potentiation 0.0448439076488947 0.152389645186647 1.20826412459979 0.833333333333333 15.2 15 2 decreased otolith number 0.0448439076488947 0.152389645186647 1.20826412459979 0.833333333333333 15.2 15 2 extremity edema 0.0448439076488947 0.152389645186647 1.20826412459979 0.833333333333333 15.2 15 2 esophageal atresia 0.0448439076488947 0.152389645186647 1.20826412459979 0.833333333333333 15.2 15 2 enlarged pancreas 0.0448439076488947 0.152389645186647 1.20826412459979 0.833333333333333 15.2 15 2 abnormal milk ejection 0.0448439076488947 0.152389645186647 1.20826412459979 0.833333333333333 15.2 15 2 abnormal metopic suture morphology 0.0448439076488947 0.152389645186647 1.20826412459979 0.833333333333333 15.2 15 2 abnormal ST segment 0.0448439076488947 0.152389645186647 1.20826412459979 0.833333333333333 15.2 15 2 abnormal cholesterol level 0.0448439076488947 0.152389645186647 1.20826412459979 0.833333333333333 15.2 15 2 abnormal extensor digitorum longus morphology 0.0448439076488947 0.152389645186647 1.20826412459979 0.833333333333333 15.2 15 2 vestibular saccular degeneration 0.0448439076488947 0.152389645186647 1.20826412459979 0.833333333333333 15.2 15 2 enlarged interparietal bone 0.0448439076488947 0.152389645186647 1.20826412459979 0.833333333333333 15.2 15 2 absent cochlear nerve compound action potential 0.0448439076488947 0.152389645186647 1.20826412459979 0.833333333333333 15.2 15 2 decreased prostate gland weight 0.0448439076488947 0.152389645186647 1.20826412459979 0.833333333333333 15.2 15 2 abnormal heart size 0.0448439076488947 0.152389645186647 1.20826412459979 0.833333333333333 15.2 15 2 abnormal pulmonary respiratory rate 0.0448439076488947 0.152389645186647 1.20826412459979 0.833333333333333 15.2 15 2 abnormal eyelid development 0.0448439076488947 0.152389645186647 1.20826412459979 0.833333333333333 15.2 15 2 delayed chorioallantoic fusion 0.0448439076488947 0.152389645186647 1.20826412459979 0.833333333333333 15.2 15 2 abnormal neural crest cell morphology 0.0448439076488947 0.152389645186647 1.20826412459979 0.833333333333333 15.2 15 2 abnormal aorta tunica adventitia morphology 0.0448439076488947 0.152389645186647 1.20826412459979 0.833333333333333 15.2 15 2 absent tongue 0.0448439076488947 0.152389645186647 1.20826412459979 0.833333333333333 15.2 15 2 abnormal orbit morphology 0.0448439076488947 0.152389645186647 1.20826412459979 0.833333333333333 15.2 15 2 increased erythrocyte clearance 0.0448439076488947 0.152389645186647 1.20826412459979 0.833333333333333 15.2 15 2 myocardium hypoplasia 0.0448439076488947 0.152389645186647 1.20826412459979 0.833333333333333 15.2 15 2 cerebral arteriovenous malformation 0.0448439076488947 0.152389645186647 1.20826412459979 0.833333333333333 15.2 15 2 abnormal pre-Botzinger complex physiology 0.0448439076488947 0.152389645186647 1.20826412459979 0.833333333333333 15.2 15 2 abnormal mandibular prominence morphology 0.0448439076488947 0.152389645186647 1.20826412459979 0.833333333333333 15.2 15 2 ectopic ureteric bud 0.0448439076488947 0.152389645186647 1.20826412459979 0.833333333333333 15.2 15 2 abnormal ureteric bud elongation 0.0448439076488947 0.152389645186647 1.20826412459979 0.833333333333333 15.2 15 2 abnormal ureteric bud tip morphology 0.0448439076488947 0.152389645186647 1.20826412459979 0.833333333333333 15.2 15 2 abnormal kidney collecting duct epithelium morphology 0.0448439076488947 0.152389645186647 1.20826412459979 0.833333333333333 15.2 15 2 abnormal endocrine pancreas development 0.0448439076488947 0.152389645186647 1.20826412459979 0.833333333333333 15.2 15 2 absent midbrain 0.0448439076488947 0.152389645186647 1.20826412459979 0.833333333333333 15.2 15 2 delayed limb development 0.0448439076488947 0.152389645186647 1.20826412459979 0.833333333333333 15.2 15 2 abnormal Rathke's pouch development 0.0448439076488947 0.152389645186647 1.20826412459979 0.833333333333333 15.2 15 2 increased CD11b-high dendritic cell number 0.0448439076488947 0.152389645186647 1.20826412459979 0.833333333333333 15.2 15 2 abnormal vertebral artery origin 0.0448439076488947 0.152389645186647 1.20826412459979 0.833333333333333 15.2 15 2 additional anastomosis between intracranial vertebral arteries 0.0448439076488947 0.152389645186647 1.20826412459979 0.833333333333333 15.2 15 2 abnormal platelet alpha-granule morphology 0.0448439076488947 0.152389645186647 1.20826412459979 0.833333333333333 15.2 15 2 increased body fat mass 0.0448439076488947 0.152389645186647 1.20826412459979 0.833333333333333 15.2 15 2 ectopic bone 0.0448439076488947 0.152389645186647 1.20826412459979 0.833333333333333 15.2 15 2 decreased hippocampus volume 0.0448439076488947 0.152389645186647 1.20826412459979 0.833333333333333 15.2 15 2 decreased tear production 0.0448439076488947 0.152389645186647 1.20826412459979 0.833333333333333 15.2 15 2 decreased capillary density 0.0448439076488947 0.152389645186647 1.20826412459979 0.833333333333333 15.2 15 2 abnormal excitatory synapse morphology 0.0448439076488947 0.152389645186647 1.20826412459979 0.833333333333333 15.2 15 2 decreased retinal apoptosis 0.0448439076488947 0.152389645186647 1.20826412459979 0.833333333333333 15.2 15 2 increased cardiac cell glucose uptake 0.0448439076488947 0.152389645186647 1.20826412459979 0.833333333333333 15.2 15 2 abnormal cell nucleus morphology 3.55576946315129e-09 1.10562206744861e-07 1.20312257513341 0.829787234042553 15.2 15 2 abnormal excitatory postsynaptic potential 5.29428387838018e-15 3.55933274255965e-13 1.20237015326028 0.829268292682927 15.2 15 2 abnormal liver development 4.12117136163839e-07 8.7994967914811e-06 1.20135975817351 0.828571428571429 15.2 15 2 abnormal spatial learning 2.60538857606292e-28 6.48090408295651e-26 1.20085146125869 0.828220858895706 15.2 15 2 abnormal hematopoietic stem cell physiology 5.02749849534177e-05 0.000616054310697667 1.19775748003806 0.826086956521739 15.2 15 2 perinatal lethality 7.78661280748719e-08 1.9466532018718e-06 1.1961814833538 0.825 15.2 15 2 abnormal cued conditioning behavior 1.39020833114919e-09 4.58032215064053e-08 1.19404925254568 0.823529411764706 15.2 15 2 overexpanded pulmonary alveoli 8.41750079134316e-07 1.62945783801293e-05 1.19404925254568 0.823529411764706 15.2 15 2 abnormal bone marrow cavity morphology 0.000576163780500566 0.00519278044925782 1.19404925254568 0.823529411764706 15.2 15 2 absence seizures 0.000576163780500566 0.00519278044925782 1.19404925254568 0.823529411764706 15.2 15 2 abnormal involuntary movement 0.000576163780500566 0.00519278044925782 1.19404925254568 0.823529411764706 15.2 15 2 enhanced behavioral response to cocaine 0.000576163780500566 0.00519278044925782 1.19404925254568 0.823529411764706 15.2 15 2 increased susceptibility to pharmacologically induced seizures 8.02114959343671e-17 7.2554944049723e-15 1.1931608230423 0.822916666666667 15.2 15 2 myoclonus 9.21111129359947e-06 0.000142757877525412 1.19100320853408 0.821428571428571 15.2 15 2 increased bone resorption 9.21111129359947e-06 0.000142757877525412 1.19100320853408 0.821428571428571 15.2 15 2 increased startle reflex 1.68894872959713e-15 1.23566469555084e-13 1.1892577226398 0.820224719101124 15.2 15 2 abnormal tail movements 0.00010259540652266 0.00116002760784144 1.18629568597071 0.818181818181818 15.2 15 2 abnormal lysosome physiology 0.00010259540652266 0.00116002760784144 1.18629568597071 0.818181818181818 15.2 15 2 abnormal cerebral cortex pyramidal cell morphology 0.00010259540652266 0.00116002760784144 1.18629568597071 0.818181818181818 15.2 15 2 abnormal sphenoid bone morphology 0.00693918946169994 0.038230861098513 1.18629568597071 0.818181818181818 15.2 15 2 abnormal thrombopoiesis 0.00693918946169994 0.038230861098513 1.18629568597071 0.818181818181818 15.2 15 2 enlarged cranium 0.00693918946169994 0.038230861098513 1.18629568597071 0.818181818181818 15.2 15 2 delayed hepatic development 0.00693918946169994 0.038230861098513 1.18629568597071 0.818181818181818 15.2 15 2 abnormal eye distance/ position 0.00693918946169994 0.038230861098513 1.18629568597071 0.818181818181818 15.2 15 2 abnormal radial glial cell morphology 0.00693918946169994 0.038230861098513 1.18629568597071 0.818181818181818 15.2 15 2 abnormal ureter development 0.00693918946169994 0.038230861098513 1.18629568597071 0.818181818181818 15.2 15 2 abnormal pituitary gland development 0.00693918946169994 0.038230861098513 1.18629568597071 0.818181818181818 15.2 15 2 abnormal coronal suture morphology 0.00693918946169994 0.038230861098513 1.18629568597071 0.818181818181818 15.2 15 2 abnormal dorsal-ventral polarity of the somites 0.00693918946169994 0.038230861098513 1.18629568597071 0.818181818181818 15.2 15 2 abnormal pulmonary alveolar sac morphology 0.00693918946169994 0.038230861098513 1.18629568597071 0.818181818181818 15.2 15 2 decreased embryonic cilium length 0.00693918946169994 0.038230861098513 1.18629568597071 0.818181818181818 15.2 15 2 reduced sympathetic cervical ganglion size 0.00693918946169994 0.038230861098513 1.18629568597071 0.818181818181818 15.2 15 2 increased neuron apoptosis 7.12836097807902e-14 4.3248287641394e-12 1.1814138107198 0.814814814814815 15.2 15 2 abnormal brain commissure morphology 1.86761574229185e-05 0.000259535986533574 1.1814138107198 0.814814814814815 15.2 15 2 abnormal single cell response 1.86761574229185e-05 0.000259535986533574 1.1814138107198 0.814814814814815 15.2 15 2 decreased anxiety-related response 3.59113157325252e-20 4.46646989423282e-18 1.17879426790224 0.813008130081301 15.2 15 2 scoliosis 3.45013556902591e-06 5.91876705375996e-05 1.1780575214848 0.8125 15.2 15 2 neonatal lethality 3.45013556902591e-06 5.91876705375996e-05 1.1780575214848 0.8125 15.2 15 2 abnormal tympanic ring morphology 0.00117478460093365 0.00938130560135616 1.1780575214848 0.8125 15.2 15 2 intraventricular hemorrhage 0.00117478460093365 0.00938130560135616 1.1780575214848 0.8125 15.2 15 2 dystonia 0.00117478460093365 0.00938130560135616 1.1780575214848 0.8125 15.2 15 2 abnormal thoracic cage shape 0.00117478460093365 0.00938130560135616 1.1780575214848 0.8125 15.2 15 2 decreased width of hypertrophic chondrocyte zone 6.44071317026681e-07 1.29726915069139e-05 1.17560833744845 0.810810810810811 15.2 15 2 abnormal reproductive system morphology 1.2117703813235e-07 2.85713632563241e-06 1.17374229246837 0.80952380952381 15.2 15 2 abnormal stapes morphology 0.000207531332299061 0.00212880077976872 1.17374229246837 0.80952380952381 15.2 15 2 abnormal placenta vasculature 4.36182461169557e-09 1.33951095328305e-07 1.1710867669198 0.807692307692308 15.2 15 2 ventricular hypoplasia 3.7584190892339e-05 0.000470985767479564 1.1710867669198 0.807692307692308 15.2 15 2 abnormal Mullerian duct morphology 3.7584190892339e-05 0.000470985767479564 1.1710867669198 0.807692307692308 15.2 15 2 abnormal lysosome morphology 1.28807948956894e-06 2.40007320621927e-05 1.1679886537798 0.805555555555556 15.2 15 2 lethality at weaning, incomplete penetrance 2.41855216357545e-07 5.41995360981435e-06 1.16700632522321 0.804878048780488 15.2 15 2 abnormal response to new environment 1.37757562131394e-05 0.000202764459054345 1.1599335596158 0.8 15.2 15 2 abnormal cell proliferation 0.000415758970548383 0.00388067707031558 1.1599335596158 0.8 15.2 15 2 absent ductus venosus valve 0.000415758970548383 0.00388067707031558 1.1599335596158 0.8 15.2 15 2 abnormal prostate gland morphology 0.00236684482920516 0.0166549547741098 1.1599335596158 0.8 15.2 15 2 hyperpigmentation 0.00236684482920516 0.0166549547741098 1.1599335596158 0.8 15.2 15 2 decreased aggression towards males 0.00236684482920516 0.0166549547741098 1.1599335596158 0.8 15.2 15 2 abnormal placenta size 0.00236684482920516 0.0166549547741098 1.1599335596158 0.8 15.2 15 2 abnormal trophectoderm morphology 0.00236684482920516 0.0166549547741098 1.1599335596158 0.8 15.2 15 2 abnormal neurotransmitter secretion 0.00236684482920516 0.0166549547741098 1.1599335596158 0.8 15.2 15 2 abnormal cerebral aqueduct morphology 0.00236684482920516 0.0166549547741098 1.1599335596158 0.8 15.2 15 2 abnormal branching involved in lung morphogenesis 0.00236684482920516 0.0166549547741098 1.1599335596158 0.8 15.2 15 2 fused cornea and lens 0.0141227184443964 0.0650560409822891 1.1599335596158 0.8 15.2 15 2 abnormal optic nerve innervation 0.0141227184443964 0.0650560409822891 1.1599335596158 0.8 15.2 15 2 rhinitis 0.0141227184443964 0.0650560409822891 1.1599335596158 0.8 15.2 15 2 acrania 0.0141227184443964 0.0650560409822891 1.1599335596158 0.8 15.2 15 2 intestinal hypoperistalsis 0.0141227184443964 0.0650560409822891 1.1599335596158 0.8 15.2 15 2 absent seminal vesicle 0.0141227184443964 0.0650560409822891 1.1599335596158 0.8 15.2 15 2 abnormal pillar cell morphology 0.0141227184443964 0.0650560409822891 1.1599335596158 0.8 15.2 15 2 abnormal hindlimb zeugopod morphology 0.0141227184443964 0.0650560409822891 1.1599335596158 0.8 15.2 15 2 abnormal gas homeostasis 0.0141227184443964 0.0650560409822891 1.1599335596158 0.8 15.2 15 2 abnormal plasma membrane morphology 0.0141227184443964 0.0650560409822891 1.1599335596158 0.8 15.2 15 2 abnormal deltoid tuberosity morphology 0.0141227184443964 0.0650560409822891 1.1599335596158 0.8 15.2 15 2 abnormal respiratory conducting tube morphology 0.0141227184443964 0.0650560409822891 1.1599335596158 0.8 15.2 15 2 osteosclerosis 0.0141227184443964 0.0650560409822891 1.1599335596158 0.8 15.2 15 2 decreased thyroxine level 0.0141227184443964 0.0650560409822891 1.1599335596158 0.8 15.2 15 2 vascular smooth muscle hyperplasia 0.0141227184443964 0.0650560409822891 1.1599335596158 0.8 15.2 15 2 impaired behavioral response to morphine 0.0141227184443964 0.0650560409822891 1.1599335596158 0.8 15.2 15 2 abnormal cerebellar granule cell migration 0.0141227184443964 0.0650560409822891 1.1599335596158 0.8 15.2 15 2 increased circulating fructosamine level 0.0141227184443964 0.0650560409822891 1.1599335596158 0.8 15.2 15 2 aorta stenosis 0.0141227184443964 0.0650560409822891 1.1599335596158 0.8 15.2 15 2 fusion of atlas and odontoid process 0.0141227184443964 0.0650560409822891 1.1599335596158 0.8 15.2 15 2 abnormal pulmonary interalveolar septum morphology 0.0141227184443964 0.0650560409822891 1.1599335596158 0.8 15.2 15 2 abnormal circadian temperature homeostasis 0.0141227184443964 0.0650560409822891 1.1599335596158 0.8 15.2 15 2 lethality during fetal growth through weaning, complete penetrance 0.0141227184443964 0.0650560409822891 1.1599335596158 0.8 15.2 15 2 abnormal cell cycle 8.79230131411551e-18 9.94129523584651e-16 1.1599335596158 0.8 15.2 15 2 increased circulating corticosterone level 9.06303421930422e-08 2.23210867529894e-06 1.1599335596158 0.8 15.2 15 2 limb grasping 7.42491534566281e-27 1.75899780212726e-24 1.15515361362837 0.796703296703297 15.2 15 2 abnormal parietal bone morphology 2.72266065175168e-05 0.000357394109299858 1.14993413237773 0.793103448275862 15.2 15 2 oligodactyly 6.65611877101662e-08 1.6724338831216e-06 1.1478509183698 0.791666666666667 15.2 15 2 abnormal malleus morphology 0.000148451437136327 0.00159169374946816 1.1478509183698 0.791666666666667 15.2 15 2 apnea 0.000148451437136327 0.00159169374946816 1.1478509183698 0.791666666666667 15.2 15 2 abnormal nervous system physiology 4.96815189063962e-17 4.84638346194747e-15 1.14732558614172 0.791304347826087 15.2 15 2 abnormal left-right axis patterning 3.50784469374503e-07 7.58762058755718e-06 1.14644596008538 0.790697674418605 15.2 15 2 abnormal axon guidance 3.50784469374503e-07 7.58762058755718e-06 1.14644596008538 0.790697674418605 15.2 15 2 seizures 9.68452298484295e-17 8.6036610445703e-15 1.14467127593665 0.789473684210526 15.2 15 2 abnormal craniofacial bone morphology 4.74123538178727e-09 1.44709484812219e-07 1.14467127593665 0.789473684210526 15.2 15 2 increased grooming behavior 1.85862071038913e-06 3.35023117180649e-05 1.14467127593665 0.789473684210526 15.2 15 2 impaired branching involved in ureteric bud morphogenesis 1.85862071038913e-06 3.35023117180649e-05 1.14467127593665 0.789473684210526 15.2 15 2 abnormal metatarsal bone morphology 0.000824073016077884 0.00697238648807394 1.14467127593665 0.789473684210526 15.2 15 2 abnormal digestive system development 0.000824073016077884 0.00697238648807394 1.14467127593665 0.789473684210526 15.2 15 2 abnormal sternebra morphology 0.000824073016077884 0.00697238648807394 1.14467127593665 0.789473684210526 15.2 15 2 embryonic lethality between implantation and somite formation, incomplete penetrance 0.000824073016077884 0.00697238648807394 1.14467127593665 0.789473684210526 15.2 15 2 abnormal behavior 1.99698579961305e-38 7.64231104082686e-36 1.14220076239146 0.787769784172662 15.2 15 2 hyperactivity 1.17062588266981e-50 9.70643961047051e-48 1.14117452630665 0.787061994609164 15.2 15 2 decreased startle reflex 7.12165112837385e-17 6.63921195347255e-15 1.1401056355198 0.786324786324786 15.2 15 2 abnormal pancreas morphology 6.84341869849931e-07 1.35641466235196e-05 1.13922046033695 0.785714285714286 15.2 15 2 abnormal brainstem morphology 5.33813265637551e-05 0.000644592474890004 1.13922046033695 0.785714285714286 15.2 15 2 prolonged QRS complex duration 5.33813265637551e-05 0.000644592474890004 1.13922046033695 0.785714285714286 15.2 15 2 abnormal blood flow velocity 0.00470402726808686 0.0276953084718723 1.13922046033695 0.785714285714286 15.2 15 2 increased hemangioma incidence 0.00470402726808686 0.0276953084718723 1.13922046033695 0.785714285714286 15.2 15 2 abnormal voluntary movement 0.00470402726808686 0.0276953084718723 1.13922046033695 0.785714285714286 15.2 15 2 abnormal maternal decidual layer morphology 0.00470402726808686 0.0276953084718723 1.13922046033695 0.785714285714286 15.2 15 2 lysosomal protein accumulation 0.00470402726808686 0.0276953084718723 1.13922046033695 0.785714285714286 15.2 15 2 abnormal viscerocranium morphology 0.00470402726808686 0.0276953084718723 1.13922046033695 0.785714285714286 15.2 15 2 increased pulmonary respiratory rate 0.00470402726808686 0.0276953084718723 1.13922046033695 0.785714285714286 15.2 15 2 decreased tongue size 0.00470402726808686 0.0276953084718723 1.13922046033695 0.785714285714286 15.2 15 2 multiple persisting craniopharyngeal ducts 0.00470402726808686 0.0276953084718723 1.13922046033695 0.785714285714286 15.2 15 2 distended abdomen 4.81770375534105e-08 1.24833730118863e-06 1.13718976432922 0.784313725490196 15.2 15 2 abnormal response to novel object 4.81770375534105e-08 1.24833730118863e-06 1.13718976432922 0.784313725490196 15.2 15 2 kidney cysts 4.78660048963099e-11 2.0888892487644e-09 1.13642139286683 0.783783783783784 15.2 15 2 malocclusion 3.62260911503462e-06 6.17208231071824e-05 1.13642139286683 0.783783783783784 15.2 15 2 abnormal breathing pattern 3.62260911503462e-06 6.17208231071824e-05 1.13642139286683 0.783783783783784 15.2 15 2 abnormal cochlear ganglion morphology 0.00029094892417193 0.0028719660669749 1.13471761266763 0.782608695652174 15.2 15 2 decreased caudal vertebrae number 1.28029310851914e-09 4.24630547658848e-08 1.13274761681231 0.78125 15.2 15 2 abnormal depression-related behavior 1.93040522810527e-05 0.000265297403586291 1.13274761681231 0.78125 15.2 15 2 abnormal embryonic hematopoiesis 1.93040522810527e-05 0.000265297403586291 1.13274761681231 0.78125 15.2 15 2 pancreatic islet hyperplasia 1.93040522810527e-05 0.000265297403586291 1.13274761681231 0.78125 15.2 15 2 increased fibroblast apoptosis 1.93040522810527e-05 0.000265297403586291 1.13274761681231 0.78125 15.2 15 2 abnormal cell differentiation 1.32710858445617e-06 2.46356910733935e-05 1.13164249718615 0.780487804878049 15.2 15 2 abnormal axon morphology 5.0545547941487e-15 3.44471371245065e-13 1.12771318295981 0.777777777777778 15.2 15 2 impaired limb coordination 3.44598701674246e-08 9.26691103151014e-07 1.12771318295981 0.777777777777778 15.2 15 2 lethality at weaning, complete penetrance 4.87332996914453e-07 1.01788609990004e-05 1.12771318295981 0.777777777777778 15.2 15 2 abnormal atrioventricular cushion morphology 0.000103762308035311 0.00117056118475209 1.12771318295981 0.777777777777778 15.2 15 2 abnormal forebrain development 1.77882346481239e-10 7.02352915669972e-09 1.12771318295981 0.777777777777778 15.2 15 2 abnormal mitral valve morphology 0.00161416808129252 0.0122415948238266 1.12771318295981 0.777777777777778 15.2 15 2 absent spleen 0.00161416808129252 0.0122415948238266 1.12771318295981 0.777777777777778 15.2 15 2 blepharoptosis 0.00161416808129252 0.0122415948238266 1.12771318295981 0.777777777777778 15.2 15 2 abnormal thymus cortex morphology 0.00161416808129252 0.0122415948238266 1.12771318295981 0.777777777777778 15.2 15 2 abnormal bile duct morphology 0.00161416808129252 0.0122415948238266 1.12771318295981 0.777777777777778 15.2 15 2 darkened coat color 0.00161416808129252 0.0122415948238266 1.12771318295981 0.777777777777778 15.2 15 2 abnormal hypoglossal nerve topology 0.00161416808129252 0.0122415948238266 1.12771318295981 0.777777777777778 15.2 15 2 abnormal head movements 0.0282049266478166 0.10695084609214 1.12771318295981 0.777777777777778 15.2 15 2 synostosis 0.0282049266478166 0.10695084609214 1.12771318295981 0.777777777777778 15.2 15 2 abnormal cholinergic neuron morphology 0.0282049266478166 0.10695084609214 1.12771318295981 0.777777777777778 15.2 15 2 abnormal kindling response 0.0282049266478166 0.10695084609214 1.12771318295981 0.777777777777778 15.2 15 2 decreased level of surface class I molecules 0.0282049266478166 0.10695084609214 1.12771318295981 0.777777777777778 15.2 15 2 abnormal posterior semicircular canal morphology 0.0282049266478166 0.10695084609214 1.12771318295981 0.777777777777778 15.2 15 2 polycythemia 0.0282049266478166 0.10695084609214 1.12771318295981 0.777777777777778 15.2 15 2 genetic imprinting 0.0282049266478166 0.10695084609214 1.12771318295981 0.777777777777778 15.2 15 2 biliary cyst 0.0282049266478166 0.10695084609214 1.12771318295981 0.777777777777778 15.2 15 2 pancreas cysts 0.0282049266478166 0.10695084609214 1.12771318295981 0.777777777777778 15.2 15 2 premature neuronal precursor differentiation 0.0282049266478166 0.10695084609214 1.12771318295981 0.777777777777778 15.2 15 2 abnormal inguinal fat pad morphology 0.0282049266478166 0.10695084609214 1.12771318295981 0.777777777777778 15.2 15 2 positive geotaxis 0.0282049266478166 0.10695084609214 1.12771318295981 0.777777777777778 15.2 15 2 abnormal retinal development 0.0282049266478166 0.10695084609214 1.12771318295981 0.777777777777778 15.2 15 2 multiflagellated sperm 0.0282049266478166 0.10695084609214 1.12771318295981 0.777777777777778 15.2 15 2 eye opacity 0.0282049266478166 0.10695084609214 1.12771318295981 0.777777777777778 15.2 15 2 abnormal hyoid bone lesser horn morphology 0.0282049266478166 0.10695084609214 1.12771318295981 0.777777777777778 15.2 15 2 axonal spheroids 0.0282049266478166 0.10695084609214 1.12771318295981 0.777777777777778 15.2 15 2 prolonged RR interval 0.0282049266478166 0.10695084609214 1.12771318295981 0.777777777777778 15.2 15 2 shortened ST segment 0.0282049266478166 0.10695084609214 1.12771318295981 0.777777777777778 15.2 15 2 fusion of atlas and occipital bones 0.0282049266478166 0.10695084609214 1.12771318295981 0.777777777777778 15.2 15 2 abnormal infrahyoid muscle connection 0.0282049266478166 0.10695084609214 1.12771318295981 0.777777777777778 15.2 15 2 symmetric azygos veins 0.0282049266478166 0.10695084609214 1.12771318295981 0.777777777777778 15.2 15 2 abnormal social investigation 2.4747144641698e-11 1.12951417057291e-09 1.12368563587781 0.775 15.2 15 2 head bobbing 2.5574312695581e-06 4.52783650037422e-05 1.12368563587781 0.775 15.2 15 2 impaired balance 4.94370006435575e-14 3.03640837286048e-12 1.1229748922751 0.774509803921569 15.2 15 2 abnormal postnatal growth/weight/body size 3.7287446601794e-05 0.00046963302998462 1.12251634801529 0.774193548387097 15.2 15 2 intracerebral hemorrhage 0.000564313479938825 0.00514186733094442 1.12039037008344 0.772727272727273 15.2 15 2 prolonged PR interval 0.000564313479938825 0.00514186733094442 1.12039037008344 0.772727272727273 15.2 15 2 abnormal temporal bone morphology 0.000564313479938825 0.00514186733094442 1.12039037008344 0.772727272727273 15.2 15 2 ataxia 4.5538380651759e-26 1.02978838064773e-23 1.11973784220337 0.772277227722772 15.2 15 2 decreased brain weight 2.44088355719216e-08 6.74633094279499e-07 1.11923413647139 0.771929824561403 15.2 15 2 impaired coordination 1.63098878789007e-43 8.11416921975307e-41 1.11886654775079 0.771676300578035 15.2 15 2 domed cranium 6.51089560828568e-10 2.28110603177614e-08 1.11850736105809 0.771428571428571 15.2 15 2 abnormal midbrain development 1.34790828926086e-05 0.000199963624650322 1.11850736105809 0.771428571428571 15.2 15 2 impaired behavioral response to xenobiotic 1.34790828926086e-05 0.000199963624650322 1.11850736105809 0.771428571428571 15.2 15 2 abnormal hippocampus pyramidal cell morphology 1.34790828926086e-05 0.000199963624650322 1.11850736105809 0.771428571428571 15.2 15 2 abnormal neural tube closure 1.76093072446704e-11 8.34345748021288e-10 1.1180082502321 0.771084337349398 15.2 15 2 abnormal embryo size 4.93709485395552e-15 3.41139540255954e-13 1.11630773989574 0.769911504424779 15.2 15 2 liver hypoplasia 1.26166999882411e-07 2.94685833058682e-06 1.11532073039981 0.769230769230769 15.2 15 2 abnormal ureter morphology 0.000199825155303452 0.00206679864373113 1.11532073039981 0.769230769230769 15.2 15 2 thick skin 0.000199825155303452 0.00206679864373113 1.11532073039981 0.769230769230769 15.2 15 2 short premaxilla 0.00920434433478821 0.048611054209736 1.11532073039981 0.769230769230769 15.2 15 2 increased foot pad pigmentation 0.00920434433478821 0.048611054209736 1.11532073039981 0.769230769230769 15.2 15 2 small trigeminal ganglion 0.00920434433478821 0.048611054209736 1.11532073039981 0.769230769230769 15.2 15 2 abnormal grip strength 0.00920434433478821 0.048611054209736 1.11532073039981 0.769230769230769 15.2 15 2 abnormal telomere length 0.00920434433478821 0.048611054209736 1.11532073039981 0.769230769230769 15.2 15 2 tracheoesophageal fistula 0.00920434433478821 0.048611054209736 1.11532073039981 0.769230769230769 15.2 15 2 abnormal aorta tunica media morphology 0.00920434433478821 0.048611054209736 1.11532073039981 0.769230769230769 15.2 15 2 delayed endochondral bone ossification 1.78508129141883e-06 3.24116037401776e-05 1.11272696125934 0.767441860465116 15.2 15 2 seminiferous tubule degeneration 4.59325297571121e-10 1.63224525386881e-08 1.11226505716584 0.767123287671233 15.2 15 2 abnormal craniofacial morphology 1.27130140011254e-13 7.52943388757129e-12 1.11207222341806 0.766990291262136 15.2 15 2 increased cellular sensitivity to gamma-irradiation 6.52969738800219e-07 1.30988889134318e-05 1.11057468473853 0.765957446808511 15.2 15 2 enlarged liver sinusoidal spaces 2.57099412940069e-05 0.00033837819560234 1.10876002022099 0.764705882352941 15.2 15 2 increased aggression towards mice 0.00312030226734116 0.0208089863002979 1.10876002022099 0.764705882352941 15.2 15 2 abnormal dorsal-ventral axis patterning 0.00312030226734116 0.0208089863002979 1.10876002022099 0.764705882352941 15.2 15 2 abnormal cranial suture morphology 0.00312030226734116 0.0208089863002979 1.10876002022099 0.764705882352941 15.2 15 2 abnormal embryonic-extraembryonic boundary morphology 0.00312030226734116 0.0208089863002979 1.10876002022099 0.764705882352941 15.2 15 2 abnormal tarsal bone morphology 0.00312030226734116 0.0208089863002979 1.10876002022099 0.764705882352941 15.2 15 2 decreased body fat mass 0.00312030226734116 0.0208089863002979 1.10876002022099 0.764705882352941 15.2 15 2 decreased rib number 8.76575234767305e-12 4.40501191208823e-10 1.10780171423981 0.764044943820225 15.2 15 2 decreased circulating total protein level 8.80453081857046e-08 2.17923088668597e-06 1.10720930690599 0.763636363636364 15.2 15 2 abnormal cell morphology 1.24817385007289e-14 8.06449987547097e-13 1.10651556673876 0.763157894736842 15.2 15 2 abnormal frontal bone morphology 9.3065717522256e-06 0.000143344255316787 1.10651556673876 0.763157894736842 15.2 15 2 decreased neuron apoptosis 9.3065717522256e-06 0.000143344255316787 1.10651556673876 0.763157894736842 15.2 15 2 abnormal eye morphology 1.80214660791896e-17 1.94906073356452e-15 1.1056920622237 0.762589928057554 15.2 15 2 abnormal posture 1.19555172115248e-10 4.83566651441757e-09 1.10556167400881 0.7625 15.2 15 2 gliosis 1.19664804189948e-08 3.50195529908818e-07 1.10469862820553 0.761904761904762 15.2 15 2 spina bifida 3.38396207119617e-06 5.84555948062533e-05 1.10469862820552 0.761904761904762 15.2 15 2 abnormal anxiety-related response 0.00108208741294622 0.00882522111378272 1.10469862820552 0.761904761904762 15.2 15 2 abnormal associative learning 0.00108208741294622 0.00882522111378272 1.10469862820552 0.761904761904762 15.2 15 2 left pulmonary isomerism 0.00108208741294622 0.00882522111378272 1.10469862820552 0.761904761904762 15.2 15 2 decreased vocalization 0.00108208741294622 0.00882522111378272 1.10469862820552 0.761904761904762 15.2 15 2 increased muscle cell glucose uptake 0.00108208741294622 0.00882522111378272 1.10469862820552 0.761904761904762 15.2 15 2 abnormal locomotor behavior 6.13967037482222e-12 3.11682246068781e-10 1.10319767898242 0.760869565217391 15.2 15 2 short stride length 4.52082743468738e-07 9.53013410490243e-06 1.10193688163501 0.76 15.2 15 2 abnormal thyroid gland morphology 0.000380970345480321 0.00361703715413091 1.10193688163501 0.76 15.2 15 2 increased cellular sensitivity to ionizing radiation 0.000380970345480321 0.00361703715413091 1.10193688163501 0.76 15.2 15 2 abnormal vertebrae development 0.000380970345480321 0.00361703715413091 1.10193688163501 0.76 15.2 15 2 abnormal spinal nerve morphology 0.000135581875280504 0.0014631666583959 1.0999369961874 0.758620689655172 15.2 15 2 decreased trophoblast giant cell number 0.000135581875280504 0.0014631666583959 1.0999369961874 0.758620689655172 15.2 15 2 blood in lymph vessels 0.000135581875280504 0.0014631666583959 1.0999369961874 0.758620689655172 15.2 15 2 abnormal motor capabilities/coordination/movement 3.18348458396463e-16 2.55448964600388e-14 1.09842193145436 0.757575757575758 15.2 15 2 abnormal neuron morphology 1.59357599468254e-12 8.71213249840179e-11 1.09842193145436 0.757575757575758 15.2 15 2 single kidney 4.86424754718478e-05 0.000597521766598624 1.09842193145436 0.757575757575758 15.2 15 2 abnormal calcium ion homeostasis 1.75608421193396e-05 0.000247493454798059 1.09723444828522 0.756756756756757 15.2 15 2 abnormal mammary gland development 6.37143159337408e-06 0.000102915169405961 1.09627866914908 0.75609756097561 15.2 15 2 perinatal lethality, complete penetrance 4.77924725830854e-25 9.510702044034e-23 1.09594661442573 0.755868544600939 15.2 15 2 abnormal rib morphology 2.21864246066522e-16 1.83962437363491e-14 1.09549280630381 0.755555555555556 15.2 15 2 absent kidney 8.48378440314057e-07 1.62960723573839e-05 1.09483524759655 0.755102040816326 15.2 15 2 abnormal maternal nurturing 4.20636250108777e-08 1.10140281278482e-06 1.09337999471981 0.754098360655738 15.2 15 2 astrocytosis 2.11946414101099e-09 6.67362917818333e-08 1.09240318114502 0.753424657534247 15.2 15 2 abnormal kidney development 7.82780803167603e-08 1.94716724787941e-06 1.08743771213981 0.75 15.2 15 2 omphalocele 4.33359234433615e-06 7.30834641121097e-05 1.08743771213981 0.75 15.2 15 2 shortened head 0.000254905252449979 0.00256192652714877 1.08743771213981 0.75 15.2 15 2 small superior cervical ganglion 0.000254905252449979 0.00256192652714877 1.08743771213981 0.75 15.2 15 2 abnormal somite shape 0.000254905252449979 0.00256192652714877 1.08743771213981 0.75 15.2 15 2 straub tail 0.000254905252449979 0.00256192652714877 1.08743771213981 0.75 15.2 15 2 failure of blastocyst to hatch from the zona pellucida 0.000254905252449979 0.00256192652714877 1.08743771213981 0.75 15.2 15 2 premature aging 0.000254905252449979 0.00256192652714877 1.08743771213981 0.75 15.2 15 2 abnormal hormone level 0.000254905252449979 0.00256192652714877 1.08743771213981 0.75 15.2 15 2 subcutaneous edema 0.000254905252449979 0.00256192652714877 1.08743771213981 0.75 15.2 15 2 abnormal basioccipital bone morphology 0.00204901515266638 0.0147309976654845 1.08743771213981 0.75 15.2 15 2 abnormal pericardium morphology 0.00204901515266638 0.0147309976654845 1.08743771213981 0.75 15.2 15 2 abnormal circulating enzyme level 0.00204901515266638 0.0147309976654845 1.08743771213981 0.75 15.2 15 2 abnormal male reproductive system physiology 0.00204901515266638 0.0147309976654845 1.08743771213981 0.75 15.2 15 2 enhanced behavioral response to xenobiotic 0.00204901515266638 0.0147309976654845 1.08743771213981 0.75 15.2 15 2 abnormal sperm mitochondrial sheath morphology 0.00204901515266638 0.0147309976654845 1.08743771213981 0.75 15.2 15 2 abnormal neuron proliferation 0.00204901515266638 0.0147309976654845 1.08743771213981 0.75 15.2 15 2 decreased exploration in new environment 2.0038820503692e-10 7.61016274853952e-09 1.08743771213981 0.75 15.2 15 2 abnormal digit morphology 3.93847286822011e-09 1.21701257884441e-07 1.08743771213981 0.75 15.2 15 2 abnormal snout morphology 5.79489304091974e-07 1.17671807667656e-05 1.08743771213981 0.75 15.2 15 2 eyelids open at birth 5.79489304091974e-07 1.17671807667656e-05 1.08743771213981 0.75 15.2 15 2 decreased kidney weight 5.79489304091974e-07 1.17671807667656e-05 1.08743771213981 0.75 15.2 15 2 curly tail 1.58234991090095e-06 2.89418779659272e-05 1.08743771213981 0.75 15.2 15 2 short radius 3.28773612221891e-05 0.000422784062563488 1.08743771213981 0.75 15.2 15 2 abnormal vertebral body morphology 9.12376295640179e-05 0.00104346484386434 1.08743771213981 0.75 15.2 15 2 bradykinesia 9.12376295640179e-05 0.00104346484386434 1.08743771213981 0.75 15.2 15 2 abnormal auditory brainstem response waveform shape 9.12376295640179e-05 0.00104346484386434 1.08743771213981 0.75 15.2 15 2 abnormal body weight 0.000718441385278738 0.00628162722629476 1.08743771213981 0.75 15.2 15 2 abnormal osteoblast morphology 0.000718441385278738 0.00628162722629476 1.08743771213981 0.75 15.2 15 2 abnormal lung saccule morphology 0.000718441385278738 0.00628162722629476 1.08743771213981 0.75 15.2 15 2 abnormal mouth morphology 0.00594302551401969 0.0337903450654263 1.08743771213981 0.75 15.2 15 2 abnormal olfaction 0.00594302551401969 0.0337903450654263 1.08743771213981 0.75 15.2 15 2 decreased cochlear coiling 0.00594302551401969 0.0337903450654263 1.08743771213981 0.75 15.2 15 2 small pancreas 0.00594302551401969 0.0337903450654263 1.08743771213981 0.75 15.2 15 2 blepharitis 0.00594302551401969 0.0337903450654263 1.08743771213981 0.75 15.2 15 2 impaired behavioral response to addictive substance 0.00594302551401969 0.0337903450654263 1.08743771213981 0.75 15.2 15 2 decreased midbrain size 0.00594302551401969 0.0337903450654263 1.08743771213981 0.75 15.2 15 2 decreased fibroblast apoptosis 0.00594302551401969 0.0337903450654263 1.08743771213981 0.75 15.2 15 2 abnormal adipose tissue distribution 0.0176876874173208 0.0777351986759459 1.08743771213981 0.75 15.2 15 2 abnormal supraoccipital bone morphology 0.0176876874173208 0.0777351986759459 1.08743771213981 0.75 15.2 15 2 impaired embryo implantation 0.0176876874173208 0.0777351986759459 1.08743771213981 0.75 15.2 15 2 myocarditis 0.0176876874173208 0.0777351986759459 1.08743771213981 0.75 15.2 15 2 abnormal embryonic growth/weight/body size 0.0176876874173208 0.0777351986759459 1.08743771213981 0.75 15.2 15 2 altered tumor susceptibility 0.0176876874173208 0.0777351986759459 1.08743771213981 0.75 15.2 15 2 increased growth rate 0.0176876874173208 0.0777351986759459 1.08743771213981 0.75 15.2 15 2 small thyroid gland 0.0176876874173208 0.0777351986759459 1.08743771213981 0.75 15.2 15 2 decreased cochlear nerve compound action potential 0.0176876874173208 0.0777351986759459 1.08743771213981 0.75 15.2 15 2 abnormal amacrine cell morphology 0.0176876874173208 0.0777351986759459 1.08743771213981 0.75 15.2 15 2 abnormal aorta elastic tissue morphology 0.0176876874173208 0.0777351986759459 1.08743771213981 0.75 15.2 15 2 decreased mammary gland epithelial cell proliferation 0.0176876874173208 0.0777351986759459 1.08743771213981 0.75 15.2 15 2 increased skeletal muscle glycogen level 0.0176876874173208 0.0777351986759459 1.08743771213981 0.75 15.2 15 2 abnormal pulmonary valve cusp morphology 0.0176876874173208 0.0777351986759459 1.08743771213981 0.75 15.2 15 2 pointed snout 0.0550429572857199 0.181952632888011 1.08743771213981 0.75 15.2 15 2 abnormal cecum morphology 0.0550429572857199 0.181952632888011 1.08743771213981 0.75 15.2 15 2 dermal cysts 0.0550429572857199 0.181952632888011 1.08743771213981 0.75 15.2 15 2 unidirectional circling 0.0550429572857199 0.181952632888011 1.08743771213981 0.75 15.2 15 2 poor grooming 0.0550429572857199 0.181952632888011 1.08743771213981 0.75 15.2 15 2 abnormal urination 0.0550429572857199 0.181952632888011 1.08743771213981 0.75 15.2 15 2 abnormal thyroid physiology 0.0550429572857199 0.181952632888011 1.08743771213981 0.75 15.2 15 2 decreased corneal stroma thickness 0.0550429572857199 0.181952632888011 1.08743771213981 0.75 15.2 15 2 hypospadia 0.0550429572857199 0.181952632888011 1.08743771213981 0.75 15.2 15 2 calcified muscle 0.0550429572857199 0.181952632888011 1.08743771213981 0.75 15.2 15 2 liver cysts 0.0550429572857199 0.181952632888011 1.08743771213981 0.75 15.2 15 2 abnormal platelet shape 0.0550429572857199 0.181952632888011 1.08743771213981 0.75 15.2 15 2 elevated level of mitotic sister chromatid exchange 0.0550429572857199 0.181952632888011 1.08743771213981 0.75 15.2 15 2 abnormal forelimb zeugopod morphology 0.0550429572857199 0.181952632888011 1.08743771213981 0.75 15.2 15 2 abnormal extraembryonic tissue physiology 0.0550429572857199 0.181952632888011 1.08743771213981 0.75 15.2 15 2 long femur 0.0550429572857199 0.181952632888011 1.08743771213981 0.75 15.2 15 2 bowed fibula 0.0550429572857199 0.181952632888011 1.08743771213981 0.75 15.2 15 2 abnormal vertebral body development 0.0550429572857199 0.181952632888011 1.08743771213981 0.75 15.2 15 2 abnormal olfactory tract morphology 0.0550429572857199 0.181952632888011 1.08743771213981 0.75 15.2 15 2 Sertoli cell hypoplasia 0.0550429572857199 0.181952632888011 1.08743771213981 0.75 15.2 15 2 ocular hypertension 0.0550429572857199 0.181952632888011 1.08743771213981 0.75 15.2 15 2 increased pulmonary ventilation 0.0550429572857199 0.181952632888011 1.08743771213981 0.75 15.2 15 2 abnormal meiotic spindle morphology 0.0550429572857199 0.181952632888011 1.08743771213981 0.75 15.2 15 2 abnormal sensory neuron physiology 0.0550429572857199 0.181952632888011 1.08743771213981 0.75 15.2 15 2 decreased quadriceps weight 0.0550429572857199 0.181952632888011 1.08743771213981 0.75 15.2 15 2 sinoatrial block 0.0550429572857199 0.181952632888011 1.08743771213981 0.75 15.2 15 2 delayed suture closure 0.0550429572857199 0.181952632888011 1.08743771213981 0.75 15.2 15 2 lung situs inversus 0.0550429572857199 0.181952632888011 1.08743771213981 0.75 15.2 15 2 abnormal bronchiole epithelium morphology 0.0550429572857199 0.181952632888011 1.08743771213981 0.75 15.2 15 2 abnormal maxillary prominence morphology 0.0550429572857199 0.181952632888011 1.08743771213981 0.75 15.2 15 2 abnormal foramen magnum morphology 0.0550429572857199 0.181952632888011 1.08743771213981 0.75 15.2 15 2 prolonged PQ interval 0.0550429572857199 0.181952632888011 1.08743771213981 0.75 15.2 15 2 increased circulating lactate level 0.0550429572857199 0.181952632888011 1.08743771213981 0.75 15.2 15 2 increased testis apoptosis 0.0550429572857199 0.181952632888011 1.08743771213981 0.75 15.2 15 2 embryo cyst 0.0550429572857199 0.181952632888011 1.08743771213981 0.75 15.2 15 2 embryonic lethality, complete penetrance 2.00223289256213e-35 7.11507760035472e-33 1.08630141359003 0.749216300940439 15.2 15 2 lethality throughout fetal growth and development, incomplete penetrance 1.93472569538545e-20 2.67368342626184e-18 1.0854126884673 0.748603351955307 15.2 15 2 preweaning lethality, incomplete penetrance 8.91518606775511e-45 4.92811674300908e-42 1.08477894022749 0.748166259168704 15.2 15 2 cleft palate 2.63007311175463e-15 1.84290334239145e-13 1.08467069506058 0.748091603053435 15.2 15 2 abnormal gait 4.94711460127124e-34 1.64079300942163e-31 1.08391849624292 0.747572815533981 15.2 15 2 abnormal locomotor activation 5.11031961585336e-11 2.19171035248883e-09 1.08345442381696 0.747252747252747 15.2 15 2 increased grip strength 5.11031961585336e-11 2.19171035248883e-09 1.08345442381696 0.747252747252747 15.2 15 2 short tail 3.7059133483937e-10 1.34576050425246e-08 1.08307049241234 0.746987951807229 15.2 15 2 abnormal neurocranium morphology 2.69681331286147e-09 8.43814228395334e-08 1.08260465564141 0.746666666666667 15.2 15 2 abnormal learning/memory/conditioning 3.93981663817474e-07 8.44852921332731e-06 1.08084718055109 0.745454545454545 15.2 15 2 small lung 1.07348554087562e-06 2.03064280070579e-05 1.08033027611276 0.745098039215686 15.2 15 2 decreased body length 8.32098797097989e-30 2.43511265621323e-27 1.07950021059135 0.744525547445255 15.2 15 2 small liver 1.84056803054094e-09 5.90762964641367e-08 1.07814337271982 0.743589743589744 15.2 15 2 failure of heart looping 2.2097986978926e-05 0.000297128338432856 1.07814337271982 0.743589743589744 15.2 15 2 abnormal action potential 1.34196527671059e-08 3.88155654164836e-07 1.07708116250039 0.742857142857143 15.2 15 2 embryonic lethality between somite formation and embryo turning, complete penetrance 1.34196527671059e-08 3.88155654164836e-07 1.07708116250039 0.742857142857143 15.2 15 2 abnormal embryonic epiblast morphology 6.10435322313794e-05 0.000724800889859457 1.07708116250039 0.742857142857143 15.2 15 2 holoprosencephaly 6.10435322313794e-05 0.000724800889859457 1.07708116250039 0.742857142857143 15.2 15 2 decreased glycogen level 6.10435322313794e-05 0.000724800889859457 1.07708116250039 0.742857142857143 15.2 15 2 decreased bone mineralization 6.10435322313794e-05 0.000724800889859457 1.07708116250039 0.742857142857143 15.2 15 2 abnormal capillary morphology 0.000169559838900597 0.00178241353484681 1.07574483351465 0.741935483870968 15.2 15 2 prenatal lethality, complete penetrance 1.31654134340945e-29 3.44725957024317e-27 1.07439889065133 0.741007194244604 15.2 15 2 abnormal neuronal precursor proliferation 7.25378840776001e-07 1.42638724618996e-05 1.07401255519982 0.740740740740741 15.2 15 2 increased brain weight 0.000474290433212427 0.00440222930080564 1.07401255519982 0.740740740740741 15.2 15 2 kyphosis 1.48939592088622e-16 1.25588893328965e-14 1.07293854264462 0.74 15.2 15 2 decreased grip strength 1.86140202952107e-23 3.30731253459547e-21 1.0725413051242 0.73972602739726 15.2 15 2 abnormal fertility/fecundity 9.10828714555117e-09 2.71339691910881e-07 1.0725413051242 0.73972602739726 15.2 15 2 abnormal cell death 5.39831109303367e-06 8.89291314166971e-05 1.07167774529721 0.739130434782609 15.2 15 2 abnormal cardiovascular development 0.00133884638794502 0.0105059318296947 1.07167774529721 0.739130434782609 15.2 15 2 abnormal Wolffian duct morphology 0.00133884638794502 0.0105059318296947 1.07167774529721 0.739130434782609 15.2 15 2 abnormal ulna morphology 0.00133884638794502 0.0105059318296947 1.07167774529721 0.739130434782609 15.2 15 2 abnormal chondrocyte physiology 0.00133884638794502 0.0105059318296947 1.07167774529721 0.739130434782609 15.2 15 2 abnormal testis morphology 5.7544700578629e-13 3.2906308664216e-11 1.07167774529721 0.739130434782609 15.2 15 2 abnormal optic nerve morphology 1.47906638831485e-05 0.000214529308509223 1.0701767960741 0.738095238095238 15.2 15 2 incomplete somite formation 4.06727991472589e-05 0.000507135778841135 1.06835985754087 0.736842105263158 15.2 15 2 abnormal reproductive system physiology 4.06727991472589e-05 0.000507135778841135 1.06835985754087 0.736842105263158 15.2 15 2 kyphoscoliosis 0.00382643426389348 0.0244057826447052 1.06835985754087 0.736842105263158 15.2 15 2 abnormal stationary movement 0.00382643426389348 0.0244057826447052 1.06835985754087 0.736842105263158 15.2 15 2 unresponsive to tactile stimuli 0.00382643426389348 0.0244057826447052 1.06835985754087 0.736842105263158 15.2 15 2 decreased chemically-elicited antinociception 0.00382643426389348 0.0244057826447052 1.06835985754087 0.736842105263158 15.2 15 2 increased malignant tumor incidence 0.00382643426389348 0.0244057826447052 1.06835985754087 0.736842105263158 15.2 15 2 abnormal response to novelty 0.00382643426389348 0.0244057826447052 1.06835985754087 0.736842105263158 15.2 15 2 abnormal blastocyst morphology 0.00382643426389348 0.0244057826447052 1.06835985754087 0.736842105263158 15.2 15 2 decreased eye pigmentation 0.00382643426389348 0.0244057826447052 1.06835985754087 0.736842105263158 15.2 15 2 Leydig cell hypoplasia 0.00382643426389348 0.0244057826447052 1.06835985754087 0.736842105263158 15.2 15 2 hydrops fetalis 1.66257682804436e-08 4.6996134770004e-07 1.06729997672982 0.736111111111111 15.2 15 2 embryonic lethality before implantation, complete penetrance 9.94228752864836e-14 5.95938318735248e-12 1.06713887484654 0.736 15.2 15 2 pale yolk sac 1.54803859744435e-09 5.06677106729319e-08 1.06560161350247 0.734939759036145 15.2 15 2 cleft secondary palate 1.45054102097655e-10 5.81971095109545e-09 1.06430073954109 0.734042553191489 15.2 15 2 increased bone mineral content 5.09981638284527e-12 2.6706933162795e-10 1.06415922900532 0.73394495412844 15.2 15 2 intracranial hemorrhage 3.28162544525303e-07 7.16056429391833e-06 1.06327242964782 0.733333333333333 15.2 15 2 emphysema 0.000312020824128451 0.00306174280086596 1.06327242964782 0.733333333333333 15.2 15 2 abnormal enteric neuron morphology 0.0111312789750115 0.0541252477720531 1.06327242964782 0.733333333333333 15.2 15 2 absent egg cylinders 0.0111312789750115 0.0541252477720531 1.06327242964782 0.733333333333333 15.2 15 2 dilated ureter 0.0111312789750115 0.0541252477720531 1.06327242964782 0.733333333333333 15.2 15 2 abnormal energy homeostasis 0.0111312789750115 0.0541252477720531 1.06327242964782 0.733333333333333 15.2 15 2 abnormal aorta wall morphology 0.0111312789750115 0.0541252477720531 1.06327242964782 0.733333333333333 15.2 15 2 herniated liver 0.0111312789750115 0.0541252477720531 1.06327242964782 0.733333333333333 15.2 15 2 heterochrony 0.0111312789750115 0.0541252477720531 1.06327242964782 0.733333333333333 15.2 15 2 irregular heartbeat 9.86805368501131e-06 0.000151523355194232 1.06327242964782 0.733333333333333 15.2 15 2 abnormal brain morphology 5.80046522966401e-17 5.54948356107277e-15 1.06267204995858 0.732919254658385 15.2 15 2 short snout 9.22953900101145e-12 4.5916956530032e-10 1.06058739825982 0.731481481481482 15.2 15 2 kinked neural tube 2.41433246928839e-06 4.28975144096777e-05 1.05955469387982 0.730769230769231 15.2 15 2 abnormal xiphoid process morphology 0.00087265014738896 0.00733350419469608 1.05955469387982 0.730769230769231 15.2 15 2 increased susceptibility to otitis media 0.00087265014738896 0.00733350419469608 1.05955469387982 0.730769230769231 15.2 15 2 increased circulating phosphate level 7.42319627998826e-05 0.000868950623363331 1.0580475037036 0.72972972972973 15.2 15 2 preweaning lethality, complete penetrance 8.72293319564162e-72 1.08491481620793e-68 1.0580475037036 0.72972972972973 15.2 15 2 small heart 6.56744999863766e-06 0.000105287598048283 1.05723110902482 0.729166666666667 15.2 15 2 double outlet right ventricle 1.66485164842584e-11 7.96407399126784e-10 1.05694880432281 0.728971962616822 15.2 15 2 infertility 1.66485164842584e-11 7.96407399126784e-10 1.05694880432281 0.728971962616822 15.2 15 2 abnormal neural tube morphology 1.27682515099352e-16 1.09520778037806e-14 1.05611234594649 0.728395061728395 15.2 15 2 abnormal head morphology 1.60910464599874e-06 2.93234271569368e-05 1.05448505419618 0.727272727272727 15.2 15 2 muscular atrophy 1.79063429937806e-05 0.000251649876819374 1.05448505419618 0.727272727272727 15.2 15 2 abnormal QRS complex 0.000204824707143138 0.00210537792982874 1.05448505419618 0.727272727272727 15.2 15 2 abnormal abdominal fat pad morphology 0.00246281790096594 0.0170885900380831 1.05448505419618 0.727272727272727 15.2 15 2 abnormal basisphenoid bone morphology 0.00246281790096594 0.0170885900380831 1.05448505419618 0.727272727272727 15.2 15 2 abnormal tracheal cartilage morphology 0.00246281790096594 0.0170885900380831 1.05448505419618 0.727272727272727 15.2 15 2 abnormal limb posture 0.00246281790096594 0.0170885900380831 1.05448505419618 0.727272727272727 15.2 15 2 increased circulating creatine kinase level 0.00246281790096594 0.0170885900380831 1.05448505419618 0.727272727272727 15.2 15 2 failure of somite differentiation 0.0332787957315871 0.12457637980786 1.05448505419618 0.727272727272727 15.2 15 2 abnormal bronchiole morphology 0.0332787957315871 0.12457637980786 1.05448505419618 0.727272727272727 15.2 15 2 abnormal vestibular ganglion morphology 0.0332787957315871 0.12457637980786 1.05448505419618 0.727272727272727 15.2 15 2 fatigue 0.0332787957315871 0.12457637980786 1.05448505419618 0.727272727272727 15.2 15 2 decreased post-tetanic potentiation 0.0332787957315871 0.12457637980786 1.05448505419618 0.727272727272727 15.2 15 2 impaired luteinization 0.0332787957315871 0.12457637980786 1.05448505419618 0.727272727272727 15.2 15 2 abnormal crista ampullaris neuroepithelium morphology 0.0332787957315871 0.12457637980786 1.05448505419618 0.727272727272727 15.2 15 2 cyclopia 0.0332787957315871 0.12457637980786 1.05448505419618 0.727272727272727 15.2 15 2 abnormal palate development 0.0332787957315871 0.12457637980786 1.05448505419618 0.727272727272727 15.2 15 2 abnormal palatal shelf elevation 0.0332787957315871 0.12457637980786 1.05448505419618 0.727272727272727 15.2 15 2 aberrant origin of the right subclavian artery 0.0332787957315871 0.12457637980786 1.05448505419618 0.727272727272727 15.2 15 2 abnormal brain ependyma motile cilium morphology 0.0332787957315871 0.12457637980786 1.05448505419618 0.727272727272727 15.2 15 2 edema 2.18297292012683e-17 2.31070005907042e-15 1.05371871331377 0.726744186046512 15.2 15 2 reduced fertility 2.53801201274753e-14 1.59830503334417e-12 1.05353677626975 0.726618705035971 15.2 15 2 decreased bone marrow cell number 3.6547093287909e-08 9.6713717610291e-07 1.05267942910338 0.726027397260274 15.2 15 2 abnormal trophoblast layer morphology 4.3622985753525e-06 7.33190385553334e-05 1.05190053200453 0.725490196078431 15.2 15 2 abnormal sternum morphology 9.82373998101334e-08 2.39574051007556e-06 1.05066445617373 0.72463768115942 15.2 15 2 decreased cell proliferation 2.50857211789701e-18 2.90235960152037e-16 1.05021011478728 0.724324324324324 15.2 15 2 abnormal middle ear morphology 0.000568129117519849 0.00515774153222856 1.04993985999706 0.724137931034483 15.2 15 2 lordosis 0.000568129117519849 0.00515774153222856 1.04993985999706 0.724137931034483 15.2 15 2 abnormal erythropoiesis 5.36234662891443e-11 2.28014311785037e-09 1.04946369679525 0.723809523809524 15.2 15 2 pulmonary hypoplasia 1.18474046995418e-05 0.000178608601152183 1.04887609114195 0.723404255319149 15.2 15 2 embryonic lethality between implantation and somite formation, complete penetrance 1.5908483174063e-23 2.93128532559124e-21 1.04749102067345 0.722448979591837 15.2 15 2 abnormal cochlea morphology 2.89309270396357e-06 5.06800570500661e-05 1.04716224131982 0.722222222222222 15.2 15 2 abnormal reflex 0.000134275576855274 0.00145986868909016 1.04716224131982 0.722222222222222 15.2 15 2 abnormal phrenic nerve morphology 0.00703625115106759 0.0384875454253152 1.04716224131982 0.722222222222222 15.2 15 2 small thoracic cage 0.00703625115106759 0.0384875454253152 1.04716224131982 0.722222222222222 15.2 15 2 increased gastrointestinal tumor incidence 0.00703625115106759 0.0384875454253152 1.04716224131982 0.722222222222222 15.2 15 2 atrioventricular block 0.00703625115106759 0.0384875454253152 1.04716224131982 0.722222222222222 15.2 15 2 abnormal metanephric mesenchyme morphology 0.00703625115106759 0.0384875454253152 1.04716224131982 0.722222222222222 15.2 15 2 decreased body size 4.99481521255247e-73 8.28306856081618e-70 1.04473965660884 0.720551378446115 15.2 15 2 abnormal bone structure 1.35645964879055e-18 1.60675875065071e-16 1.0442407045764 0.72020725388601 15.2 15 2 abnormal inner ear vestibule morphology 0.00158622405904609 0.0122415948238266 1.04394020365422 0.72 15.2 15 2 abnormal primitive streak morphology 0.00158622405904609 0.0122415948238266 1.04394020365422 0.72 15.2 15 2 abnormal cochlear outer hair cell morphology 0.00158622405904609 0.0122415948238266 1.04394020365422 0.72 15.2 15 2 incomplete embryo turning 1.91633611429922e-06 3.44179500672875e-05 1.04292271807561 0.719298245614035 15.2 15 2 abnormal spongiotrophoblast layer morphology 0.000369716596094077 0.00353040319686763 1.04212780746732 0.71875 15.2 15 2 abnormal allantois morphology 2.12143233415699e-05 0.000287557575652987 1.040157811612 0.717391304347826 15.2 15 2 atrial septal defect 2.12143233415699e-05 0.000287557575652987 1.040157811612 0.717391304347826 15.2 15 2 abnormal motor coordination/ balance 4.52973110143344e-10 1.62125267839074e-08 1.03983942844346 0.717171717171717 15.2 15 2 decreased circulating serum albumin level 4.52973110143344e-10 1.62125267839074e-08 1.03983942844346 0.717171717171717 15.2 15 2 atrioventricular septal defect 5.16758672075815e-06 8.59824211898722e-05 1.03956309588209 0.716981132075472 15.2 15 2 perinatal lethality, incomplete penetrance 4.41848254383227e-21 6.4652796045781e-19 1.03932099921327 0.716814159292035 15.2 15 2 increased circulating alkaline phosphatase level 1.85174799712944e-15 1.33513714285782e-13 1.03821213669316 0.716049382716049 15.2 15 2 increased exploration in new environment 1.9300550551275e-08 5.39439544902209e-07 1.03821213669316 0.716049382716049 15.2 15 2 kinked tail 3.01863811647017e-10 1.11242404662512e-08 1.03768565995041 0.715686274509804 15.2 15 2 ovary cysts 0.000240595026968696 0.0024578239407993 1.03565496394268 0.714285714285714 15.2 15 2 abnormal jaw morphology 0.00102275338511855 0.00843813945433629 1.03565496394268 0.714285714285714 15.2 15 2 absent corpus callosum 0.00102275338511855 0.00843813945433629 1.03565496394268 0.714285714285714 15.2 15 2 hypoxia 0.00102275338511855 0.00843813945433629 1.03565496394268 0.714285714285714 15.2 15 2 abnormal interparietal bone morphology 0.0204551370015417 0.0883370716863455 1.03565496394268 0.714285714285714 15.2 15 2 midline facial cleft 0.0204551370015417 0.0883370716863455 1.03565496394268 0.714285714285714 15.2 15 2 abnormal adrenal gland secretion 0.0204551370015417 0.0883370716863455 1.03565496394268 0.714285714285714 15.2 15 2 increased lactate dehydrogenase level 0.0204551370015417 0.0883370716863455 1.03565496394268 0.714285714285714 15.2 15 2 abnormal prepulse inhibition 0.0204551370015417 0.0883370716863455 1.03565496394268 0.714285714285714 15.2 15 2 amyloid beta deposits 0.0204551370015417 0.0883370716863455 1.03565496394268 0.714285714285714 15.2 15 2 absent olfactory bulb 0.0204551370015417 0.0883370716863455 1.03565496394268 0.714285714285714 15.2 15 2 abnormal imprinting 0.0204551370015417 0.0883370716863455 1.03565496394268 0.714285714285714 15.2 15 2 skeletal muscle necrosis 0.0204551370015417 0.0883370716863455 1.03565496394268 0.714285714285714 15.2 15 2 abnormal squamosal bone morphology 0.0204551370015417 0.0883370716863455 1.03565496394268 0.714285714285714 15.2 15 2 premature hair loss 0.0204551370015417 0.0883370716863455 1.03565496394268 0.714285714285714 15.2 15 2 spina bifida occulta 0.0204551370015417 0.0883370716863455 1.03565496394268 0.714285714285714 15.2 15 2 decreased cornea thickness 0.0204551370015417 0.0883370716863455 1.03565496394268 0.714285714285714 15.2 15 2 increased stomach tumor incidence 0.0204551370015417 0.0883370716863455 1.03565496394268 0.714285714285714 15.2 15 2 abnormal renal tubule epithelial cell primary cilium morphology 0.0204551370015417 0.0883370716863455 1.03565496394268 0.714285714285714 15.2 15 2 asymmetric rib joints 0.104362346487883 0.274855835774071 1.03565496394268 0.714285714285714 15.2 15 2 absent hair follicles 0.104362346487883 0.274855835774071 1.03565496394268 0.714285714285714 15.2 15 2 abnormal foot pad morphology 0.104362346487883 0.274855835774071 1.03565496394268 0.714285714285714 15.2 15 2 mammary gland hyperplasia 0.104362346487883 0.274855835774071 1.03565496394268 0.714285714285714 15.2 15 2 decreased Schwann cell number 0.104362346487883 0.274855835774071 1.03565496394268 0.714285714285714 15.2 15 2 skin photosensitivity 0.104362346487883 0.274855835774071 1.03565496394268 0.714285714285714 15.2 15 2 abnormal lacrimal gland morphology 0.104362346487883 0.274855835774071 1.03565496394268 0.714285714285714 15.2 15 2 abnormal vascular permeability 0.104362346487883 0.274855835774071 1.03565496394268 0.714285714285714 15.2 15 2 abnormal brain ventricular system morphology 0.104362346487883 0.274855835774071 1.03565496394268 0.714285714285714 15.2 15 2 abnormal melanocyte morphology 0.104362346487883 0.274855835774071 1.03565496394268 0.714285714285714 15.2 15 2 abnormal adrenal gland physiology 0.104362346487883 0.274855835774071 1.03565496394268 0.714285714285714 15.2 15 2 increased retinal ganglion cell number 0.104362346487883 0.274855835774071 1.03565496394268 0.714285714285714 15.2 15 2 decreased mortality induced by ionizing radiation 0.104362346487883 0.274855835774071 1.03565496394268 0.714285714285714 15.2 15 2 decreased lateral semicircular canal size 0.104362346487883 0.274855835774071 1.03565496394268 0.714285714285714 15.2 15 2 increased muscle weight 0.104362346487883 0.274855835774071 1.03565496394268 0.714285714285714 15.2 15 2 increased cell nucleus count 0.104362346487883 0.274855835774071 1.03565496394268 0.714285714285714 15.2 15 2 skeletal muscle interstitial fibrosis 0.104362346487883 0.274855835774071 1.03565496394268 0.714285714285714 15.2 15 2 abnormal nephron morphology 0.104362346487883 0.274855835774071 1.03565496394268 0.714285714285714 15.2 15 2 increased ectoderm apoptosis 0.104362346487883 0.274855835774071 1.03565496394268 0.714285714285714 15.2 15 2 abnormal organ of Corti supporting cell morphology 0.104362346487883 0.274855835774071 1.03565496394268 0.714285714285714 15.2 15 2 absent deltoid tuberosity 0.104362346487883 0.274855835774071 1.03565496394268 0.714285714285714 15.2 15 2 abnormal strial marginal cell morphology 0.104362346487883 0.274855835774071 1.03565496394268 0.714285714285714 15.2 15 2 decreased adrenocorticotropin level 0.104362346487883 0.274855835774071 1.03565496394268 0.714285714285714 15.2 15 2 abnormal thyroid hormone level 0.104362346487883 0.274855835774071 1.03565496394268 0.714285714285714 15.2 15 2 decreased tidal volume 0.104362346487883 0.274855835774071 1.03565496394268 0.714285714285714 15.2 15 2 arteritis 0.104362346487883 0.274855835774071 1.03565496394268 0.714285714285714 15.2 15 2 decreased brain cholesterol level 0.104362346487883 0.274855835774071 1.03565496394268 0.714285714285714 15.2 15 2 focal dorsal hair loss 0.104362346487883 0.274855835774071 1.03565496394268 0.714285714285714 15.2 15 2 coronary fistula 0.104362346487883 0.274855835774071 1.03565496394268 0.714285714285714 15.2 15 2 long stride length 0.104362346487883 0.274855835774071 1.03565496394268 0.714285714285714 15.2 15 2 abnormal conotruncal ridge morphology 0.104362346487883 0.274855835774071 1.03565496394268 0.714285714285714 15.2 15 2 altered tumor pathology 0.104362346487883 0.274855835774071 1.03565496394268 0.714285714285714 15.2 15 2 abnormal impulsive behavior control 0.104362346487883 0.274855835774071 1.03565496394268 0.714285714285714 15.2 15 2 small lung saccule 0.104362346487883 0.274855835774071 1.03565496394268 0.714285714285714 15.2 15 2 small lung lobe 0.104362346487883 0.274855835774071 1.03565496394268 0.714285714285714 15.2 15 2 impaired branching involved in bronchus morphogenesis 0.104362346487883 0.274855835774071 1.03565496394268 0.714285714285714 15.2 15 2 abnormal brain ependyma motile cilium physiology 0.104362346487883 0.274855835774071 1.03565496394268 0.714285714285714 15.2 15 2 decreased areal bone mineral density 0.104362346487883 0.274855835774071 1.03565496394268 0.714285714285714 15.2 15 2 fragmented Meckel's cartilage 0.104362346487883 0.274855835774071 1.03565496394268 0.714285714285714 15.2 15 2 absent connection between subcutaneous lymph vessels and lymph sac 0.104362346487883 0.274855835774071 1.03565496394268 0.714285714285714 15.2 15 2 embryo tumor 0.104362346487883 0.274855835774071 1.03565496394268 0.714285714285714 15.2 15 2 decreased collagen level 0.104362346487883 0.274855835774071 1.03565496394268 0.714285714285714 15.2 15 2 increased T cell derived lymphoma incidence 1.39488592677625e-05 0.000204706710492975 1.03565496394268 0.714285714285714 15.2 15 2 small ears 0.00446633450196681 0.0273645494424691 1.03565496394268 0.714285714285714 15.2 15 2 abnormal eye pigmentation 0.00446633450196681 0.0273645494424691 1.03565496394268 0.714285714285714 15.2 15 2 trunk curl 0.00446633450196681 0.0273645494424691 1.03565496394268 0.714285714285714 15.2 15 2 embryonic lethality at implantation, complete penetrance 0.00446633450196681 0.0273645494424691 1.03565496394268 0.714285714285714 15.2 15 2 hydroencephaly 3.36204863944639e-11 1.49340999832552e-09 1.03385382487495 0.71304347826087 15.2 15 2 short limbs 8.50979090597242e-09 2.55037408175981e-07 1.03327414793362 0.71264367816092 15.2 15 2 insulin resistance 1.41941558744995e-12 7.84621394173723e-11 1.0325166155671 0.712121212121212 15.2 15 2 impaired swimming 5.53996148951706e-07 1.13889704174989e-05 1.0325166155671 0.712121212121212 15.2 15 2 decreased embryo size 1.56139993775487e-41 6.47330390860872e-39 1.03132167957472 0.711297071129707 15.2 15 2 lethality throughout fetal growth and development, complete penetrance 2.75601403440988e-17 2.79819792269167e-15 1.03020414834298 0.710526315789474 15.2 15 2 decreased birth body size 5.91390684141769e-11 2.4933632657672e-09 1.03020414834298 0.710526315789474 15.2 15 2 persistence of hyaloid vascular system 0.000156604455401776 0.00167190378889235 1.03020414834298 0.710526315789474 15.2 15 2 abnormal eyelid morphology 0.000660258788018761 0.00585523613260844 1.02897331901402 0.709677419354839 15.2 15 2 inner cell mass degeneration 0.000660258788018761 0.00585523613260844 1.02897331901402 0.709677419354839 15.2 15 2 preaxial polydactyly 0.000660258788018761 0.00585523613260844 1.02897331901402 0.709677419354839 15.2 15 2 abnormal cranium morphology 1.6575298900278e-12 8.96327304661773e-11 1.02792619555505 0.708955223880597 15.2 15 2 abnormal neuromuscular synapse morphology 2.41497180832744e-07 5.41995360981435e-06 1.02702450590982 0.708333333333333 15.2 15 2 abnormal nursing 0.00284554425156314 0.0194458552905585 1.02702450590982 0.708333333333333 15.2 15 2 abnormal startle reflex 0.00284554425156314 0.0194458552905585 1.02702450590982 0.708333333333333 15.2 15 2 blindness 0.00284554425156314 0.0194458552905585 1.02702450590982 0.708333333333333 15.2 15 2 abnormal sensory capabilities/reflexes/nociception 0.00284554425156314 0.0194458552905585 1.02702450590982 0.708333333333333 15.2 15 2 increased hemangiosarcoma incidence 0.00284554425156314 0.0194458552905585 1.02702450590982 0.708333333333333 15.2 15 2 increased body temperature 0.00284554425156314 0.0194458552905585 1.02702450590982 0.708333333333333 15.2 15 2 short humerus 0.000101971895796275 0.00116002760784144 1.02555101307495 0.707317073170732 15.2 15 2 abnormal extraembryonic tissue morphology 1.08784921597107e-09 3.70688345853156e-08 1.0234707878963 0.705882352941177 15.2 15 2 short maxilla 0.000426778501968628 0.00396864120989519 1.0234707878963 0.705882352941177 15.2 15 2 abnormal nervous system development 0.000426778501968628 0.00396864120989519 1.0234707878963 0.705882352941177 15.2 15 2 abnormal adipose tissue morphology 0.0127175613060482 0.0602123726874326 1.0234707878963 0.705882352941177 15.2 15 2 abnormal vagus nerve morphology 0.0127175613060482 0.0602123726874326 1.0234707878963 0.705882352941177 15.2 15 2 abnormal heart rate 0.0127175613060482 0.0602123726874326 1.0234707878963 0.705882352941177 15.2 15 2 abnormal ectoplacental cone morphology 0.0127175613060482 0.0602123726874326 1.0234707878963 0.705882352941177 15.2 15 2 decreased growth hormone level 0.0127175613060482 0.0602123726874326 1.0234707878963 0.705882352941177 15.2 15 2 common atrium 0.0127175613060482 0.0602123726874326 1.0234707878963 0.705882352941177 15.2 15 2 abnormal ductus venosus valve morphology 0.0127175613060482 0.0602123726874326 1.0234707878963 0.705882352941177 15.2 15 2 absent gastric milk in neonates 1.05115749729868e-07 2.53859638303929e-06 1.02237733619982 0.705128205128205 15.2 15 2 increased embryonic tissue cell apoptosis 1.05115749729868e-07 2.53859638303929e-06 1.02237733619982 0.705128205128205 15.2 15 2 increased anxiety-related response 1.27627634107663e-12 7.1342413447823e-11 1.02224360469738 0.705035971223022 15.2 15 2 reduced male fertility 1.18118931404541e-19 1.43327239935998e-17 1.02196789393463 0.704845814977974 15.2 15 2 postnatal lethality 9.08907081774936e-15 5.94975359451356e-13 1.02192941622778 0.704819277108434 15.2 15 2 hyperglycemia 1.73185827247729e-08 4.86779373196299e-07 1.02153239625255 0.704545454545455 15.2 15 2 embryonic lethality, incomplete penetrance 6.64275209869395e-05 0.000783120656184892 1.02153239625255 0.704545454545455 15.2 15 2 prenatal lethality, incomplete penetrance 1.12891122214621e-25 2.44188405659887e-23 1.02066522104351 0.703947368421053 15.2 15 2 neurodegeneration 1.05695100106453e-05 0.000160314976533416 1.02031192743983 0.703703703703704 15.2 15 2 abnormal cell adhesion 1.05695100106453e-05 0.000160314976533416 1.02031192743983 0.703703703703704 15.2 15 2 abnormal long bone epiphyseal plate proliferative zone 1.05695100106453e-05 0.000160314976533416 1.02031192743983 0.703703703703704 15.2 15 2 abnormal trigeminal nerve morphology 0.00181875446855823 0.0136888101075298 1.02031192743983 0.703703703703704 15.2 15 2 abnormal fetal cardiomyocyte proliferation 0.00181875446855823 0.0136888101075298 1.02031192743983 0.703703703703704 15.2 15 2 abnormal eye muscle morphology 0.00181875446855823 0.0136888101075298 1.02031192743983 0.703703703703704 15.2 15 2 small spleen 1.14361563011719e-08 3.38659985704347e-07 1.01972181065125 0.703296703296703 15.2 15 2 abnormal innervation 4.32934887120646e-05 0.000535783846623187 1.01802679434366 0.702127659574468 15.2 15 2 neuron degeneration 4.32934887120646e-05 0.000535783846623187 1.01802679434366 0.702127659574468 15.2 15 2 increased respiratory quotient 4.32934887120646e-05 0.000535783846623187 1.01802679434366 0.702127659574468 15.2 15 2 absent vitelline blood vessels 6.91955026739711e-06 0.000109633001848091 1.01748557861035 0.701754385964912 15.2 15 2 increased total body fat amount 5.81530035690989e-12 2.98258961604399e-10 1.01710591981236 0.701492537313433 15.2 15 2 decreased white adipose tissue amount 1.1204587647055e-06 2.11147058879162e-05 1.01710591981236 0.701492537313433 15.2 15 2 postnatal lethality, incomplete penetrance 7.93413117822613e-46 5.63890037309643e-43 1.01596293293814 0.700704225352113 15.2 15 2 neonatal lethality, incomplete penetrance 1.28919514979443e-21 2.00429558444603e-19 1.01494186466383 0.7 15.2 15 2 abnormal hindlimb morphology 2.82299269069381e-05 0.000368619124309757 1.01494186466383 0.7 15.2 15 2 increased B cell derived lymphoma incidence 2.82299269069381e-05 0.000368619124309757 1.01494186466383 0.7 15.2 15 2 abnormal heart tube morphology 0.00116571513543311 0.0093690352161223 1.01494186466383 0.7 15.2 15 2 disorganized myocardium 0.00116571513543311 0.0093690352161223 1.01494186466383 0.7 15.2 15 2 abnormal optic cup morphology 0.00116571513543311 0.0093690352161223 1.01494186466383 0.7 15.2 15 2 abnormal dopamine level 0.00797374552342337 0.0429322337435403 1.01494186466383 0.7 15.2 15 2 abnormal hearing physiology 0.00797374552342337 0.0429322337435403 1.01494186466383 0.7 15.2 15 2 absent placental labyrinth 0.00797374552342337 0.0429322337435403 1.01494186466383 0.7 15.2 15 2 retarded hair growth 0.0610634124557971 0.193859851904012 1.01494186466383 0.7 15.2 15 2 kidney hemorrhage 0.0610634124557971 0.193859851904012 1.01494186466383 0.7 15.2 15 2 abnormal grooming behavior 0.0610634124557971 0.193859851904012 1.01494186466383 0.7 15.2 15 2 absent trophoblast giant cells 0.0610634124557971 0.193859851904012 1.01494186466383 0.7 15.2 15 2 abnormal mammary gland physiology 0.0610634124557971 0.193859851904012 1.01494186466383 0.7 15.2 15 2 decreased incidence of induced tumors 0.0610634124557971 0.193859851904012 1.01494186466383 0.7 15.2 15 2 impaired social transmission of food preference 0.0610634124557971 0.193859851904012 1.01494186466383 0.7 15.2 15 2 aneurysm 0.0610634124557971 0.193859851904012 1.01494186466383 0.7 15.2 15 2 bifid ureter 0.0610634124557971 0.193859851904012 1.01494186466383 0.7 15.2 15 2 cochlear ganglion hypoplasia 0.0610634124557971 0.193859851904012 1.01494186466383 0.7 15.2 15 2 abnormal submandibular gland morphology 0.0610634124557971 0.193859851904012 1.01494186466383 0.7 15.2 15 2 abnormal embryonic erythrocyte morphology 0.0610634124557971 0.193859851904012 1.01494186466383 0.7 15.2 15 2 abnormal utricular macula morphology 0.0610634124557971 0.193859851904012 1.01494186466383 0.7 15.2 15 2 decreased cochlear inner hair cell number 0.0610634124557971 0.193859851904012 1.01494186466383 0.7 15.2 15 2 increased platelet aggregation 0.0610634124557971 0.193859851904012 1.01494186466383 0.7 15.2 15 2 abnormal spinal cord dorsal column morphology 0.0610634124557971 0.193859851904012 1.01494186466383 0.7 15.2 15 2 ventricular premature beat 0.0610634124557971 0.193859851904012 1.01494186466383 0.7 15.2 15 2 abnormal sperm principal piece morphology 0.0610634124557971 0.193859851904012 1.01494186466383 0.7 15.2 15 2 decreased transitional stage T2 B cell number 0.0610634124557971 0.193859851904012 1.01494186466383 0.7 15.2 15 2 abnormal retinal blood vessel pattern 0.0610634124557971 0.193859851904012 1.01494186466383 0.7 15.2 15 2 abnormal heart and great artery attachment 0.0610634124557971 0.193859851904012 1.01494186466383 0.7 15.2 15 2 thin ventricle myocardium compact layer 0.0610634124557971 0.193859851904012 1.01494186466383 0.7 15.2 15 2 thick aortic valve cusps 0.0610634124557971 0.193859851904012 1.01494186466383 0.7 15.2 15 2 sinus bradycardia 0.0610634124557971 0.193859851904012 1.01494186466383 0.7 15.2 15 2 decreased trabecular bone connectivity density 0.0610634124557971 0.193859851904012 1.01494186466383 0.7 15.2 15 2 decreased circulating lactate level 0.0610634124557971 0.193859851904012 1.01494186466383 0.7 15.2 15 2 enlarged kidney 1.84165761307342e-05 0.000257366478231467 1.01220617230624 0.69811320754717 15.2 15 2 abnormal vasculogenesis 0.000116068931720911 0.00129762457373379 1.01156996478122 0.697674418604651 15.2 15 2 abnormal axial skeleton morphology 3.17338619817413e-07 6.95488825370761e-06 1.01112629374404 0.697368421052632 15.2 15 2 abnormal vertebrae morphology 9.44283028213665e-10 3.23986763128481e-08 1.01095126755506 0.697247706422018 15.2 15 2 enhanced long term potentiation 1.20203042625966e-05 0.00018066771512513 1.00976358984411 0.696428571428571 15.2 15 2 hunched posture 2.08422492655282e-07 4.77834977400935e-06 1.00943585093147 0.69620253164557 15.2 15 2 abnormal somite development 2.08422492655282e-07 4.77834977400935e-06 1.00943585093147 0.69620253164557 15.2 15 2 abnormal spermatogenesis 2.62786951836633e-15 1.84290334239145e-13 1.00863787792678 0.695652173913043 15.2 15 2 decreased spleen weight 1.27347836112905e-06 2.3817875363222e-05 1.00863787792678 0.695652173913043 15.2 15 2 failure to gastrulate 7.53582223225056e-05 0.000875951299192676 1.00863787792678 0.695652173913043 15.2 15 2 abnormal carpal bone morphology 0.00503189564501377 0.0292108294445082 1.00863787792678 0.695652173913043 15.2 15 2 abnormal innervation pattern to muscle 0.00503189564501377 0.0292108294445082 1.00863787792678 0.695652173913043 15.2 15 2 increased susceptibility to age related obesity 0.00503189564501377 0.0292108294445082 1.00863787792678 0.695652173913043 15.2 15 2 abnormal corneal stroma morphology 0.00503189564501377 0.0292108294445082 1.00863787792678 0.695652173913043 15.2 15 2 hypoactivity 1.09910522646724e-29 3.03780472315252e-27 1.00763459091293 0.694960212201592 15.2 15 2 syndactyly 7.84914928416304e-06 0.000123574423065542 1.00756940559847 0.694915254237288 15.2 15 2 abnormal limb bone morphology 0.000482230140862832 0.00445101104043152 1.00688677049983 0.694444444444444 15.2 15 2 abnormal trophoblast giant cell morphology 0.000482230140862832 0.00445101104043152 1.00688677049983 0.694444444444444 15.2 15 2 narrow eye opening 0.000482230140862832 0.00445101104043152 1.00688677049983 0.694444444444444 15.2 15 2 increased tumor incidence 1.17760624038164e-10 4.80212380811364e-09 1.0055875617637 0.693548387096774 15.2 15 2 decreased leukocyte cell number 1.29988415924878e-11 6.3401212669242e-10 1.00541686280567 0.693430656934307 15.2 15 2 delayed bone ossification 5.47006626645367e-07 1.12919417741108e-05 1.00527575166703 0.693333333333333 15.2 15 2 abnormal suckling behavior 5.90759411258648e-08 1.50719388257014e-06 1.00505606728074 0.693181818181818 15.2 15 2 small kidney 5.90759411258648e-08 1.50719388257014e-06 1.00505606728074 0.693181818181818 15.2 15 2 embryonic lethality during organogenesis, complete penetrance 7.39553101493109e-43 3.34479698175292e-40 1.0045853150244 0.692857142857143 15.2 15 2 cyanosis 1.30000024201058e-15 9.65298687164576e-14 1.00436955357358 0.692708333333333 15.2 15 2 increased percent body fat/body weight 3.18515263037306e-05 0.000411587904833922 1.00378865735983 0.692307692307692 15.2 15 2 abnormal iris morphology 0.000311067666828533 0.00305842221832402 1.00378865735983 0.692307692307692 15.2 15 2 abnormal Schwann cell morphology 0.00319176536027462 0.0210597250230322 1.00378865735983 0.692307692307692 15.2 15 2 heart inflammation 0.00319176536027462 0.0210597250230322 1.00378865735983 0.692307692307692 15.2 15 2 decreased circulating glycerol level 0.00319176536027462 0.0210597250230322 1.00378865735983 0.692307692307692 15.2 15 2 abnormal nerve conduction 0.00319176536027462 0.0210597250230322 1.00378865735983 0.692307692307692 15.2 15 2 increased thymocyte apoptosis 0.00319176536027462 0.0210597250230322 1.00378865735983 0.692307692307692 15.2 15 2 abnormal sympathetic ganglion morphology 0.0367752093530189 0.135724530067707 1.00378865735983 0.692307692307692 15.2 15 2 pup cannibalization 0.0367752093530189 0.135724530067707 1.00378865735983 0.692307692307692 15.2 15 2 lymphoid hypoplasia 0.0367752093530189 0.135724530067707 1.00378865735983 0.692307692307692 15.2 15 2 abnormal tail bud morphology 0.0367752093530189 0.135724530067707 1.00378865735983 0.692307692307692 15.2 15 2 abnormal coping response 0.0367752093530189 0.135724530067707 1.00378865735983 0.692307692307692 15.2 15 2 abnormal dopaminergic neuron morphology 0.0367752093530189 0.135724530067707 1.00378865735983 0.692307692307692 15.2 15 2 abnormal GABAergic neuron morphology 0.0367752093530189 0.135724530067707 1.00378865735983 0.692307692307692 15.2 15 2 muscle fatigue 0.0367752093530189 0.135724530067707 1.00378865735983 0.692307692307692 15.2 15 2 vestibular hair cell degeneration 0.0367752093530189 0.135724530067707 1.00378865735983 0.692307692307692 15.2 15 2 small interparietal bone 0.0367752093530189 0.135724530067707 1.00378865735983 0.692307692307692 15.2 15 2 increased circulating thyroid-stimulating hormone level 0.0367752093530189 0.135724530067707 1.00378865735983 0.692307692307692 15.2 15 2 decreased luteinizing hormone level 0.0367752093530189 0.135724530067707 1.00378865735983 0.692307692307692 15.2 15 2 abnormal exocrine pancreas morphology 0.0367752093530189 0.135724530067707 1.00378865735983 0.692307692307692 15.2 15 2 hyperalgesia 0.0367752093530189 0.135724530067707 1.00378865735983 0.692307692307692 15.2 15 2 abnormal embryo development 2.22417168471778e-11 1.02456056772879e-09 1.00214847981512 0.691176470588235 15.2 15 2 ventricular septal defect 2.22417168471778e-11 1.02456056772879e-09 1.00214847981512 0.691176470588235 15.2 15 2 abnormal embryo turning 2.0732713762699e-05 0.000283366074091834 1.00176080148637 0.690909090909091 15.2 15 2 abnormal joint morphology 2.0732713762699e-05 0.000283366074091834 1.00176080148637 0.690909090909091 15.2 15 2 disheveled coat 0.000200988532902269 0.00207451857093109 1.00113313181126 0.69047619047619 15.2 15 2 increased circulating free fatty acid level 1.43312753518588e-06 2.63092601016596e-05 1.00064690882349 0.690140845070423 15.2 15 2 cochlear ganglion degeneration 1.35050809814087e-05 0.000199963624650322 0.999942723806725 0.689655172413793 15.2 15 2 abnormal outer ear morphology 0.00203302953533788 0.0147309976654845 0.999942723806725 0.689655172413793 15.2 15 2 abnormal embryonic erythropoiesis 0.00203302953533788 0.0147309976654845 0.999942723806725 0.689655172413793 15.2 15 2 short sternum 0.00203302953533788 0.0147309976654845 0.999942723806725 0.689655172413793 15.2 15 2 postnatal growth retardation 1.10493775915247e-45 6.87133168972943e-43 0.99977933447277 0.689542483660131 15.2 15 2 small seminiferous tubules 9.37699274642087e-07 1.78737696986375e-05 0.99926708683118 0.689189189189189 15.2 15 2 decreased body weight 7.11727294487378e-92 3.54084329007471e-88 0.999013859402543 0.689014539579968 15.2 15 2 abnormal cartilage development 0.000130054178882235 0.00141890249986649 0.998831676335829 0.688888888888889 15.2 15 2 small placenta 0.000130054178882235 0.00141890249986649 0.998831676335829 0.688888888888889 15.2 15 2 abnormal lumbar vertebrae morphology 0.00129945161025307 0.0102778565357854 0.996817902794829 0.6875 15.2 15 2 increased fatty acid level 0.00129945161025307 0.0102778565357854 0.996817902794829 0.6875 15.2 15 2 vasculature congestion 0.0225454365891934 0.0942550815388549 0.996817902794829 0.6875 15.2 15 2 disorganized retinal layers 0.0225454365891934 0.0942550815388549 0.996817902794829 0.6875 15.2 15 2 reduced male mating frequency 0.0225454365891934 0.0942550815388549 0.996817902794829 0.6875 15.2 15 2 paternal imprinting 0.0225454365891934 0.0942550815388549 0.996817902794829 0.6875 15.2 15 2 abnormal pulmonary elastic fiber morphology 0.0225454365891934 0.0942550815388549 0.996817902794829 0.6875 15.2 15 2 increased pancreatic beta cell number 0.0225454365891934 0.0942550815388549 0.996817902794829 0.6875 15.2 15 2 bowed tibia 0.0225454365891934 0.0942550815388549 0.996817902794829 0.6875 15.2 15 2 decreased circulating growth hormone level 0.0225454365891934 0.0942550815388549 0.996817902794829 0.6875 15.2 15 2 decreased circulating prolactin level 0.0225454365891934 0.0942550815388549 0.996817902794829 0.6875 15.2 15 2 impaired somite development 0.0225454365891934 0.0942550815388549 0.996817902794829 0.6875 15.2 15 2 decreased liver cholesterol level 0.0225454365891934 0.0942550815388549 0.996817902794829 0.6875 15.2 15 2 decreased skeletal muscle weight 0.0225454365891934 0.0942550815388549 0.996817902794829 0.6875 15.2 15 2 impaired hematopoiesis 5.46612218323551e-05 0.000656858885545814 0.995041043788065 0.686274509803922 15.2 15 2 increased oxygen consumption 1.72414231412679e-07 4.0082280433555e-06 0.994710465368202 0.686046511627907 15.2 15 2 increased carcinoma incidence 0.000832996992877571 0.00702400006706088 0.994228765384973 0.685714285714286 15.2 15 2 decreased triglyceride level 0.000832996992877571 0.00702400006706088 0.994228765384973 0.685714285714286 15.2 15 2 anophthalmia 1.12982322740183e-07 2.68941174943737e-06 0.99376330247983 0.685393258426966 15.2 15 2 increased insulin sensitivity 1.83881745376471e-11 8.6302988985655e-10 0.993649377992557 0.685314685314685 15.2 15 2 abnormal chondrocyte morphology 3.54954847450451e-05 0.000451636922267518 0.99346161355983 0.685185185185185 15.2 15 2 abnormal mandible morphology 3.54954847450451e-05 0.000451636922267518 0.99346161355983 0.685185185185185 15.2 15 2 axon degeneration 3.54954847450451e-05 0.000451636922267518 0.99346161355983 0.685185185185185 15.2 15 2 impaired righting response 4.85521761974524e-08 1.25153925690324e-06 0.992048439145093 0.684210526315789 15.2 15 2 increased bone marrow cell number 0.000535313693691847 0.00490457758032586 0.992048439145093 0.684210526315789 15.2 15 2 decreased hair follicle number 0.000535313693691847 0.00490457758032586 0.992048439145093 0.684210526315789 15.2 15 2 decreased grooming behavior 0.0139908544066115 0.0650560409822891 0.992048439145093 0.684210526315789 15.2 15 2 abnormal ear morphology 0.0139908544066115 0.0650560409822891 0.992048439145093 0.684210526315789 15.2 15 2 abnormal neurotransmitter level 0.0139908544066115 0.0650560409822891 0.992048439145093 0.684210526315789 15.2 15 2 abnormal nasal septum morphology 0.0139908544066115 0.0650560409822891 0.992048439145093 0.684210526315789 15.2 15 2 polydactyly 3.18388335121666e-08 8.65563916519282e-07 0.991269751202279 0.683673469387755 15.2 15 2 abnormal placenta labyrinth morphology 6.83031929774928e-07 1.35641466235196e-05 0.991082471823628 0.683544303797468 15.2 15 2 abnormal nervous system morphology 6.83031929774928e-07 1.35641466235196e-05 0.991082471823628 0.683544303797468 15.2 15 2 abnormal eating behavior 1.50097723271875e-05 0.000216445267616689 0.99077658217183 0.683333333333333 15.2 15 2 absent mesoderm 1.50097723271875e-05 0.000216445267616689 0.99077658217183 0.683333333333333 15.2 15 2 decreased circulating cholesterol level 4.75137494311295e-14 2.95476129274836e-12 0.99038042999983 0.683060109289617 15.2 15 2 short ulna 0.000344752177659099 0.00333685230321793 0.990187185037879 0.682926829268293 15.2 15 2 hemopericardium 0.000344752177659099 0.00333685230321793 0.990187185037879 0.682926829268293 15.2 15 2 decreased bone mineral content 9.96695854751104e-16 7.51297254149506e-14 0.98984714822983 0.682692307692308 15.2 15 2 embryonic lethality during organogenesis, incomplete penetrance 3.17779850114615e-17 3.16190950864042e-15 0.989725917715656 0.682608695652174 15.2 15 2 circling 2.9235665791705e-07 6.46433054727699e-06 0.989355094966419 0.682352941176471 15.2 15 2 abnormal vascular development 6.36738713644208e-06 0.000102915169405961 0.988579738308922 0.681818181818182 15.2 15 2 abnormal facial nerve morphology 0.00875958436125438 0.0466583856501505 0.988579738308922 0.681818181818182 15.2 15 2 increased skin papilloma incidence 0.00875958436125438 0.0466583856501505 0.988579738308922 0.681818181818182 15.2 15 2 abnormal chorion morphology 0.00875958436125438 0.0466583856501505 0.988579738308922 0.681818181818182 15.2 15 2 increased coping response 0.00875958436125438 0.0466583856501505 0.988579738308922 0.681818181818182 15.2 15 2 abnormal cochlear sensory epithelium morphology 0.00875958436125438 0.0466583856501505 0.988579738308922 0.681818181818182 15.2 15 2 increased mammary gland tumor incidence 0.00875958436125438 0.0466583856501505 0.988579738308922 0.681818181818182 15.2 15 2 increased adenoma incidence 0.00875958436125438 0.0466583856501505 0.988579738308922 0.681818181818182 15.2 15 2 increased bone volume 0.00875958436125438 0.0466583856501505 0.988579738308922 0.681818181818182 15.2 15 2 increased circulating insulin level 2.52138992228116e-12 1.33445902801582e-10 0.987755921860331 0.68125 15.2 15 2 small testis 3.58041920180196e-20 4.46646989423282e-18 0.987624588803309 0.681159420289855 15.2 15 2 microcephaly 4.15147579271577e-06 7.02503131590509e-05 0.987624588803309 0.681159420289855 15.2 15 2 decreased circulating glucose level 2.35703326621204e-20 3.08585276300129e-18 0.987398639457895 0.681003584229391 15.2 15 2 pallor 3.10971986733887e-13 1.7989367837222e-11 0.985943525673431 0.68 15.2 15 2 enlarged liver 3.52425085153162e-08 9.37601496597315e-07 0.985943525673431 0.68 15.2 15 2 decreased heart rate 3.52425085153162e-08 9.37601496597315e-07 0.985943525673431 0.68 15.2 15 2 spontaneous skin ulceration 0.00552159966066187 0.0318677010577642 0.985943525673431 0.68 15.2 15 2 diaphragmatic hernia 0.00552159966066187 0.0318677010577642 0.985943525673431 0.68 15.2 15 2 abnormal energy expenditure 0.00552159966066187 0.0318677010577642 0.985943525673431 0.68 15.2 15 2 abnormal preimplantation embryo development 0.00552159966066187 0.0318677010577642 0.985943525673431 0.68 15.2 15 2 increased rib number 1.15462836354695e-06 2.16765136175324e-05 0.985199978519831 0.67948717948718 15.2 15 2 extramedullary hematopoiesis 1.5147420649854e-08 4.33094354787493e-07 0.984849248730397 0.679245283018868 15.2 15 2 increased body weight 2.29522206942719e-16 1.87192291727873e-14 0.983872215745546 0.678571428571429 15.2 15 2 abnormal coat/hair pigmentation 6.51614152893153e-09 1.96471540038996e-07 0.983872215745546 0.678571428571429 15.2 15 2 abnormal neuron differentiation 6.51614152893153e-09 1.96471540038996e-07 0.983872215745546 0.678571428571429 15.2 15 2 rib bifurcation 0.00349920120026423 0.0227265352105934 0.983872215745546 0.678571428571429 15.2 15 2 increased or absent threshold for auditory brainstem response 1.24746121376959e-20 1.77317701100106e-18 0.983334678567029 0.678200692041522 15.2 15 2 abnormal seminiferous tubule morphology 3.80560745136614e-11 1.67547761686252e-09 0.983162863030517 0.678082191780822 15.2 15 2 oxidative stress 2.11012260117522e-07 4.81553208295722e-06 0.982721488007832 0.677777777777778 15.2 15 2 prenatal lethality 1.6521065109054e-05 0.000234166093782176 0.98220180451338 0.67741935483871 15.2 15 2 decreased thymus weight 0.00222717346500324 0.0158514849619329 0.98220180451338 0.67741935483871 15.2 15 2 abnormal podocyte morphology 0.00222717346500324 0.0158514849619329 0.98220180451338 0.67741935483871 15.2 15 2 abnormal mitochondrial ATP synthesis coupled electron transport 0.00222717346500324 0.0158514849619329 0.98220180451338 0.67741935483871 15.2 15 2 reduced female fertility 1.09521336794477e-16 9.55909913250042e-15 0.981193797735349 0.676724137931034 15.2 15 2 decreased total body fat amount 2.32538909665224e-23 3.98924508822237e-21 0.981081528716958 0.676646706586826 15.2 15 2 hemorrhage 7.20638081381945e-17 6.63921195347255e-15 0.981007638185704 0.676595744680851 15.2 15 2 decreased liver weight 4.56170319422076e-06 7.64123683207013e-05 0.980225543337297 0.676056338028169 15.2 15 2 respiratory failure 2.74997004217321e-11 1.24373645089197e-09 0.97941409835109 0.675496688741722 15.2 15 2 premature death 1.46702206568641e-57 1.45968695535798e-54 0.978399242358857 0.67479674796748 15.2 15 2 abnormal muscle physiology 3.53559890823313e-07 7.61454743223368e-06 0.977472100799833 0.674157303370786 15.2 15 2 organ of Corti degeneration 0.000157056810541614 0.00167314268189407 0.976474680288812 0.673469387755102 15.2 15 2 impaired glucose tolerance 2.47000538815338e-17 2.5600576679298e-15 0.9763553652008 0.673387096774194 15.2 15 2 distended pericardium 0.000101622359685405 0.00115956706292406 0.975905639099833 0.673076923076923 15.2 15 2 increased sacral vertebrae number 1.8026572263365e-05 0.000252625907071102 0.974162950458583 0.671875 15.2 15 2 rib fusion 1.17272951925973e-05 0.000177335238854624 0.973824816841624 0.671641791044776 15.2 15 2 abnormal blood vessel morphology 1.92284171709831e-10 7.41561049811169e-09 0.969944442092523 0.668965517241379 15.2 15 2 epidermal hyperplasia 4.62173721671919e-05 0.000569137194385594 0.966611299679835 0.666666666666667 15.2 15 2 abnormal incisor morphology 4.62173721671919e-05 0.000569137194385594 0.966611299679835 0.666666666666667 15.2 15 2 increased cell proliferation 0.000109915057578963 0.00123159326904356 0.966611299679835 0.666666666666667 15.2 15 2 polyphagia 0.000109915057578963 0.00123159326904356 0.966611299679835 0.666666666666667 15.2 15 2 abnormal apoptosis 0.000109915057578963 0.00123159326904356 0.966611299679835 0.666666666666667 15.2 15 2 abnormal gastrulation 0.000169821912666812 0.00178241353484681 0.966611299679835 0.666666666666667 15.2 15 2 abnormal cervical vertebrae morphology 0.000169821912666812 0.00178241353484681 0.966611299679835 0.666666666666667 15.2 15 2 failure of chorioallantoic fusion 0.000169821912666812 0.00178241353484681 0.966611299679835 0.666666666666667 15.2 15 2 abnormal tooth development 0.00240041894939673 0.0167725902714167 0.966611299679835 0.666666666666667 15.2 15 2 dextrocardia 0.00240041894939673 0.0167725902714167 0.966611299679835 0.666666666666667 15.2 15 2 abnormal ovarian folliculogenesis 0.00240041894939673 0.0167725902714167 0.966611299679835 0.666666666666667 15.2 15 2 abnormal middle ear ossicle morphology 0.00240041894939673 0.0167725902714167 0.966611299679835 0.666666666666667 15.2 15 2 head tossing 0.00240041894939673 0.0167725902714167 0.966611299679835 0.666666666666667 15.2 15 2 abnormal lactation 0.00376765833514743 0.0243114140302963 0.966611299679835 0.666666666666667 15.2 15 2 abnormal pain threshold 0.00376765833514743 0.0243114140302963 0.966611299679835 0.666666666666667 15.2 15 2 abnormal heart valve morphology 0.00593778714370745 0.0337903450654263 0.966611299679835 0.666666666666667 15.2 15 2 abnormal trigeminal ganglion morphology 0.00593778714370745 0.0337903450654263 0.966611299679835 0.666666666666667 15.2 15 2 thin epidermis 0.00593778714370745 0.0337903450654263 0.966611299679835 0.666666666666667 15.2 15 2 abnormal bone trabecula morphology 0.00593778714370745 0.0337903450654263 0.966611299679835 0.666666666666667 15.2 15 2 decreased bone ossification 0.00593778714370745 0.0337903450654263 0.966611299679835 0.666666666666667 15.2 15 2 audiogenic seizures 0.0391028530546021 0.142517724503037 0.966611299679835 0.666666666666667 15.2 15 2 abnormal respiratory system morphology 0.0391028530546021 0.142517724503037 0.966611299679835 0.666666666666667 15.2 15 2 abnormal cricoid cartilage morphology 0.0391028530546021 0.142517724503037 0.966611299679835 0.666666666666667 15.2 15 2 altered righting response 0.0391028530546021 0.142517724503037 0.966611299679835 0.666666666666667 15.2 15 2 abnormal pericyte morphology 0.0391028530546021 0.142517724503037 0.966611299679835 0.666666666666667 15.2 15 2 abnormal ear development 0.0391028530546021 0.142517724503037 0.966611299679835 0.666666666666667 15.2 15 2 immune system phenotype 0.0391028530546021 0.142517724503037 0.966611299679835 0.666666666666667 15.2 15 2 abnormal secondary palate development 0.0391028530546021 0.142517724503037 0.966611299679835 0.666666666666667 15.2 15 2 abnormal microglial cell activation 0.0391028530546021 0.142517724503037 0.966611299679835 0.666666666666667 15.2 15 2 abnormal autopod morphology 0.000407221792116655 0.00381530775099879 0.966611299679834 0.666666666666667 15.2 15 2 abnormal limb morphology 5.38793404559938e-06 8.89291314166971e-05 0.966611299679834 0.666666666666667 15.2 15 2 overriding aortic valve 0.000262759302370482 0.0026249548780987 0.966611299679834 0.666666666666667 15.2 15 2 abnormal phalanx morphology 0.000262759302370482 0.0026249548780987 0.966611299679834 0.666666666666667 15.2 15 2 abnormal retinal blood vessel morphology 0.00153453069690706 0.01194724603617 0.966611299679834 0.666666666666667 15.2 15 2 decreased body height 0.00940459843191506 0.0493484241847983 0.966611299679834 0.666666666666667 15.2 15 2 abnormal retinal ganglion layer morphology 0.00940459843191506 0.0493484241847983 0.966611299679834 0.666666666666667 15.2 15 2 abnormal truncus arteriosus septation 0.00940459843191506 0.0493484241847983 0.966611299679834 0.666666666666667 15.2 15 2 abnormal clavicle morphology 0.0149885675663365 0.0687263812373495 0.966611299679834 0.666666666666667 15.2 15 2 vascular ring 0.0149885675663365 0.0687263812373495 0.966611299679834 0.666666666666667 15.2 15 2 absent segment of posterior cerebral artery 0.0149885675663365 0.0687263812373495 0.966611299679834 0.666666666666667 15.2 15 2 lowered ear position 0.0240801816160095 0.0991712777646088 0.966611299679834 0.666666666666667 15.2 15 2 abnormal heart shape 0.0240801816160095 0.0991712777646088 0.966611299679834 0.666666666666667 15.2 15 2 underdeveloped hair follicles 0.0240801816160095 0.0991712777646088 0.966611299679834 0.666666666666667 15.2 15 2 right pulmonary isomerism 0.0240801816160095 0.0991712777646088 0.966611299679834 0.666666666666667 15.2 15 2 abnormal radius morphology 0.0240801816160095 0.0991712777646088 0.966611299679834 0.666666666666667 15.2 15 2 eye inflammation 0.0240801816160095 0.0991712777646088 0.966611299679834 0.666666666666667 15.2 15 2 abnormal thyroid cartilage morphology 0.0240801816160095 0.0991712777646088 0.966611299679834 0.666666666666667 15.2 15 2 abnormal metacarpal bone morphology 0.0240801816160095 0.0991712777646088 0.966611299679834 0.666666666666667 15.2 15 2 absent allantois 0.0240801816160095 0.0991712777646088 0.966611299679834 0.666666666666667 15.2 15 2 decreased cellular sensitivity to gamma-irradiation 0.0240801816160095 0.0991712777646088 0.966611299679834 0.666666666666667 15.2 15 2 abnormal body wall morphology 0.0240801816160095 0.0991712777646088 0.966611299679834 0.666666666666667 15.2 15 2 long tibia 0.0240801816160095 0.0991712777646088 0.966611299679834 0.666666666666667 15.2 15 2 absent inner cell mass 0.0240801816160095 0.0991712777646088 0.966611299679834 0.666666666666667 15.2 15 2 abnormal anterior eye segment morphology 0.0240801816160095 0.0991712777646088 0.966611299679834 0.666666666666667 15.2 15 2 abnormal pregnancy 0.0240801816160095 0.0991712777646088 0.966611299679834 0.666666666666667 15.2 15 2 decreased tumor latency 0.0240801816160095 0.0991712777646088 0.966611299679834 0.666666666666667 15.2 15 2 primary atelectasis 0.0240801816160095 0.0991712777646088 0.966611299679834 0.666666666666667 15.2 15 2 abnormal esophagus morphology 0.0644610123601199 0.193859851904012 0.966611299679834 0.666666666666667 15.2 15 2 abnormal glossopharyngeal nerve morphology 0.0644610123601199 0.193859851904012 0.966611299679834 0.666666666666667 15.2 15 2 absent optic nerve 0.0644610123601199 0.193859851904012 0.966611299679834 0.666666666666667 15.2 15 2 interstitial pneumonia 0.0644610123601199 0.193859851904012 0.966611299679834 0.666666666666667 15.2 15 2 increased papilloma incidence 0.0644610123601199 0.193859851904012 0.966611299679834 0.666666666666667 15.2 15 2 abnormal alisphenoid bone morphology 0.0644610123601199 0.193859851904012 0.966611299679834 0.666666666666667 15.2 15 2 loss of dopaminergic neurons 0.0644610123601199 0.193859851904012 0.966611299679834 0.666666666666667 15.2 15 2 dilated bile duct 0.0644610123601199 0.193859851904012 0.966611299679834 0.666666666666667 15.2 15 2 abnormal defecation 0.0644610123601199 0.193859851904012 0.966611299679834 0.666666666666667 15.2 15 2 pale placenta 0.0644610123601199 0.193859851904012 0.966611299679834 0.666666666666667 15.2 15 2 absent cochlear hair cells 0.0644610123601199 0.193859851904012 0.966611299679834 0.666666666666667 15.2 15 2 small parietal bone 0.0644610123601199 0.193859851904012 0.966611299679834 0.666666666666667 15.2 15 2 abnormal thymus corticomedullary boundary morphology 0.0644610123601199 0.193859851904012 0.966611299679834 0.666666666666667 15.2 15 2 increased fibrosarcoma incidence 0.0644610123601199 0.193859851904012 0.966611299679834 0.666666666666667 15.2 15 2 increased type II pneumocyte number 0.0644610123601199 0.193859851904012 0.966611299679834 0.666666666666667 15.2 15 2 decreased compensatory feeding amount 0.0644610123601199 0.193859851904012 0.966611299679834 0.666666666666667 15.2 15 2 abnormal vitelline vein connection 0.0644610123601199 0.193859851904012 0.966611299679834 0.666666666666667 15.2 15 2 heart hyperplasia 0.108719018561526 0.276298884214047 0.966611299679834 0.666666666666667 15.2 15 2 renal tubular acidosis 0.108719018561526 0.276298884214047 0.966611299679834 0.666666666666667 15.2 15 2 thick tail 0.108719018561526 0.276298884214047 0.966611299679834 0.666666666666667 15.2 15 2 abnormal sympathetic neuron morphology 0.108719018561526 0.276298884214047 0.966611299679834 0.666666666666667 15.2 15 2 abnormal geniculate ganglion morphology 0.108719018561526 0.276298884214047 0.966611299679834 0.666666666666667 15.2 15 2 abnormal ion homeostasis 0.108719018561526 0.276298884214047 0.966611299679834 0.666666666666667 15.2 15 2 abnormal postural reflex 0.108719018561526 0.276298884214047 0.966611299679834 0.666666666666667 15.2 15 2 abnormal lens capsule morphology 0.108719018561526 0.276298884214047 0.966611299679834 0.666666666666667 15.2 15 2 abnormal artery development 0.108719018561526 0.276298884214047 0.966611299679834 0.666666666666667 15.2 15 2 abnormal thymus physiology 0.108719018561526 0.276298884214047 0.966611299679834 0.666666666666667 15.2 15 2 small scapula 0.108719018561526 0.276298884214047 0.966611299679834 0.666666666666667 15.2 15 2 short frontal bone 0.108719018561526 0.276298884214047 0.966611299679834 0.666666666666667 15.2 15 2 absent cochlear outer hair cells 0.108719018561526 0.276298884214047 0.966611299679834 0.666666666666667 15.2 15 2 abnormal hair cell mechanoelectric transduction 0.108719018561526 0.276298884214047 0.966611299679834 0.666666666666667 15.2 15 2 abnormal gallbladder physiology 0.108719018561526 0.276298884214047 0.966611299679834 0.666666666666667 15.2 15 2 decreased thyroid-stimulating hormone level 0.108719018561526 0.276298884214047 0.966611299679834 0.666666666666667 15.2 15 2 liver hyperplasia 0.108719018561526 0.276298884214047 0.966611299679834 0.666666666666667 15.2 15 2 abnormal posterior eye segment morphology 0.108719018561526 0.276298884214047 0.966611299679834 0.666666666666667 15.2 15 2 hemothorax 0.108719018561526 0.276298884214047 0.966611299679834 0.666666666666667 15.2 15 2 decreased transitional stage T1 B cell number 0.108719018561526 0.276298884214047 0.966611299679834 0.666666666666667 15.2 15 2 abnormal cerebellar layer morphology 0.108719018561526 0.276298884214047 0.966611299679834 0.666666666666667 15.2 15 2 iris coloboma 0.108719018561526 0.276298884214047 0.966611299679834 0.666666666666667 15.2 15 2 decreased effector memory CD4-positive, alpha-beta T cell number 0.108719018561526 0.276298884214047 0.966611299679834 0.666666666666667 15.2 15 2 abnormal oxidative phosphorylation 0.108719018561526 0.276298884214047 0.966611299679834 0.666666666666667 15.2 15 2 abnormal ureteric bud invasion 0.108719018561526 0.276298884214047 0.966611299679834 0.666666666666667 15.2 15 2 increased core body temperature 0.108719018561526 0.276298884214047 0.966611299679834 0.666666666666667 15.2 15 2 decreased pancreatic beta cell proliferation 0.108719018561526 0.276298884214047 0.966611299679834 0.666666666666667 15.2 15 2 decreased bone trabecular spacing 0.108719018561526 0.276298884214047 0.966611299679834 0.666666666666667 15.2 15 2 increased myeloid cell number 0.108719018561526 0.276298884214047 0.966611299679834 0.666666666666667 15.2 15 2 abnormal ductus venosus valve topology 0.108719018561526 0.276298884214047 0.966611299679834 0.666666666666667 15.2 15 2 decreased fatty acid oxidation 0.108719018561526 0.276298884214047 0.966611299679834 0.666666666666667 15.2 15 2 decreased bone mineral density of femur 0.108719018561526 0.276298884214047 0.966611299679834 0.666666666666667 15.2 15 2 increased endoplasmic reticulum stress 0.108719018561526 0.276298884214047 0.966611299679834 0.666666666666667 15.2 15 2 decreased platelet dense granule number 0.108719018561526 0.276298884214047 0.966611299679834 0.666666666666667 15.2 15 2 postnatal lethality, complete penetrance 9.02681196525051e-25 1.72724575104313e-22 0.965359212504083 0.66580310880829 15.2 15 2 abnormal glucose homeostasis 2.21945853234671e-12 1.18729098907795e-10 0.963955774131263 0.664835164835165 15.2 15 2 decreased birth weight 4.50123173635307e-07 9.52920335674745e-06 0.961523871786783 0.663157894736842 15.2 15 2 increased granulocyte number 8.89513308651214e-06 0.000139161280205654 0.960080142249565 0.662162162162162 15.2 15 2 male infertility 5.57975565082809e-31 1.73495527267936e-28 0.959885376123414 0.662027833001988 15.2 15 2 atelectasis 1.36545229429578e-05 0.000201576414365624 0.959804177851103 0.661971830985915 15.2 15 2 pericardial edema 2.09759484881518e-05 0.000285905051311111 0.959503863652777 0.661764705882353 15.2 15 2 abnormal thoracic vertebrae morphology 7.64380572768369e-05 0.000884370546400613 0.958419678496107 0.661016949152542 15.2 15 2 short mandible 0.00011786630109744 0.00131182292608449 0.957980841646979 0.660714285714286 15.2 15 2 abnormal eye development 0.00011786630109744 0.00131182292608449 0.957980841646979 0.660714285714286 15.2 15 2 abnormal mesoderm development 0.00018196748597338 0.00189390845756813 0.957492325154553 0.660377358490566 15.2 15 2 abnormal embryonic tissue morphology 6.04547749749582e-10 2.13306741489657e-08 0.956747919070856 0.659863945578231 15.2 15 2 embryonic growth arrest 1.27749806101187e-14 8.14814468401799e-13 0.956058774574159 0.65938864628821 15.2 15 2 osteoporosis 0.00067549682741887 0.0059585048163278 0.955627080365291 0.659090909090909 15.2 15 2 abnormal circadian rhythm 0.00067549682741887 0.0059585048163278 0.955627080365291 0.659090909090909 15.2 15 2 decreased blood urea nitrogen level 0.00067549682741887 0.0059585048163278 0.955627080365291 0.659090909090909 15.2 15 2 anemia 1.57686805448124e-13 9.22931596593431e-12 0.955158559162301 0.658767772511848 15.2 15 2 abnormal developmental patterning 4.04922763809933e-06 6.87539505103896e-05 0.954823357000812 0.658536585365854 15.2 15 2 liver fibrosis 0.00104969336076991 0.00864606700303028 0.954823357000812 0.658536585365854 15.2 15 2 abnormal heart development 1.83548006201679e-10 7.13399477229182e-09 0.954375713607938 0.658227848101266 15.2 15 2 decreased bone volume 0.00255277966763562 0.0176881320981716 0.952802566827265 0.657142857142857 15.2 15 2 abnormal lymphatic vessel morphology 0.00399827882407175 0.0254366203961086 0.951507998122337 0.65625 15.2 15 2 abnormal heart atrium morphology 0.00399827882407175 0.0254366203961086 0.951507998122337 0.65625 15.2 15 2 increased circulating triglyceride level 1.59982708415584e-09 5.20205212004921e-08 0.949945587616389 0.655172413793103 15.2 15 2 abnormal embryonic neuroepithelium morphology 0.000125427866856056 0.00138360008338997 0.949945587616389 0.655172413793103 15.2 15 2 thrombocytosis 0.000125427866856056 0.00138360008338997 0.949945587616389 0.655172413793103 15.2 15 2 aphagia 0.00628492736362428 0.0356122023166638 0.949945587616389 0.655172413793103 15.2 15 2 increased retinal apoptosis 0.00628492736362428 0.0356122023166638 0.949945587616389 0.655172413793103 15.2 15 2 abnormal skeleton development 6.60296092282697e-06 0.000105287598048283 0.948711090426504 0.654320987654321 15.2 15 2 decreased heart weight 6.60296092282697e-06 0.000105287598048283 0.948711090426504 0.654320987654321 15.2 15 2 azoospermia 3.177632058794e-10 1.16240584503678e-08 0.948373350629272 0.654088050314465 15.2 15 2 abnormal cornea morphology 1.01153371557301e-05 0.000154842468768483 0.948022620839837 0.653846153846154 15.2 15 2 abnormal stomach morphology 0.00992239778361555 0.0502687667754454 0.948022620839837 0.653846153846154 15.2 15 2 no spontaneous movement 0.00992239778361555 0.0502687667754454 0.948022620839837 0.653846153846154 15.2 15 2 increased leukemia incidence 0.00992239778361555 0.0502687667754454 0.948022620839837 0.653846153846154 15.2 15 2 microphthalmia 7.35201644764477e-10 2.55778194594635e-08 0.947658136941014 0.65359477124183 15.2 15 2 abnormal sleep pattern 0.000714964235262243 0.00628162722629476 0.94559801055636 0.652173913043478 15.2 15 2 abnormal myelin sheath morphology 0.000714964235262243 0.00628162722629476 0.94559801055636 0.652173913043478 15.2 15 2 abnormal pulmonary artery morphology 0.0157490007042055 0.0717502550397642 0.94559801055636 0.652173913043478 15.2 15 2 abnormal cranial nerve morphology 0.0157490007042055 0.0717502550397642 0.94559801055636 0.652173913043478 15.2 15 2 bidirectional circling 0.0157490007042055 0.0717502550397642 0.94559801055636 0.652173913043478 15.2 15 2 abnormal circulating insulin level 0.0157490007042055 0.0717502550397642 0.94559801055636 0.652173913043478 15.2 15 2 conjunctivitis 0.0157490007042055 0.0717502550397642 0.94559801055636 0.652173913043478 15.2 15 2 dilated heart 0.0157490007042055 0.0717502550397642 0.94559801055636 0.652173913043478 15.2 15 2 abnormal skeleton morphology 1.07464841356217e-07 2.58279026931005e-06 0.94559801055636 0.652173913043478 15.2 15 2 abnormal food intake 3.64977288924815e-05 0.000460853302639837 0.94559801055636 0.652173913043478 15.2 15 2 perimembraneous ventricular septal defect 3.64977288924815e-05 0.000460853302639837 0.94559801055636 0.652173913043478 15.2 15 2 abnormal organ of Corti morphology 0.00110900008657643 0.00901515593254534 0.944131967129141 0.651162790697674 15.2 15 2 abnormal male reproductive system morphology 0.00110900008657643 0.00901515593254534 0.944131967129141 0.651162790697674 15.2 15 2 small gonad 0.0251654851896752 0.10338421867765 0.942446017187839 0.65 15.2 15 2 dilated vasculature 0.0251654851896752 0.10338421867765 0.942446017187839 0.65 15.2 15 2 abnormal response to tactile stimuli 0.0251654851896752 0.10338421867765 0.942446017187839 0.65 15.2 15 2 decreased double-positive T cell number 8.86893096463083e-07 1.69703582880917e-05 0.942446017187838 0.65 15.2 15 2 decreased erythrocyte cell number 8.2640553172209e-10 2.85511633355375e-08 0.941984260197546 0.64968152866242 15.2 15 2 obese 1.63884976104169e-05 0.000232950787462355 0.941504512675163 0.649350649350649 15.2 15 2 neonatal lethality, complete penetrance 1.43414415540664e-25 2.97286132214502e-23 0.941174160214576 0.649122807017544 15.2 15 2 increased hepatocellular carcinoma incidence 0.000204138169068315 0.00210266540603492 0.941174160214576 0.649122807017544 15.2 15 2 pale liver 2.51092837474013e-05 0.000332230549583302 0.940486669958758 0.648648648648649 15.2 15 2 abnormal chromosome morphology 0.00268480366798068 0.0185512475669498 0.940486669958758 0.648648648648649 15.2 15 2 abnormal humerus morphology 0.00268480366798068 0.0185512475669498 0.940486669958758 0.648648648648649 15.2 15 2 decreased circulating HDL cholesterol level 3.40268435735944e-08 9.20019275970827e-07 0.940180521954214 0.6484375 15.2 15 2 increased thermal nociceptive threshold 3.15668507369245e-06 5.49108679776921e-05 0.940056044194125 0.648351648351648 15.2 15 2 increased circulating cholesterol level 1.1397616829843e-10 4.68621022549332e-09 0.939150751393475 0.647727272727273 15.2 15 2 teratozoospermia 4.82282195667298e-06 8.05152323303627e-05 0.939150751393475 0.647727272727273 15.2 15 2 decreased litter size 3.83247109494089e-16 3.02643550751285e-14 0.9390921167708 0.647686832740214 15.2 15 2 increased circulating HDL cholesterol level 6.13439442078209e-07 1.24059399363378e-05 0.938993833974696 0.647619047619048 15.2 15 2 decreased mean corpuscular hemoglobin 5.90477732631268e-05 0.000707861860202544 0.938181555571604 0.647058823529412 15.2 15 2 abnormal vision 0.00419301961697678 0.0265735956617318 0.938181555571604 0.647058823529412 15.2 15 2 abnormal brown adipose tissue morphology 0.00419301961697678 0.0265735956617318 0.938181555571604 0.647058823529412 15.2 15 2 abnormal urinary bladder morphology 0.0405632079416262 0.146021678371628 0.938181555571604 0.647058823529412 15.2 15 2 increased incidence of corneal inflammation 0.0405632079416262 0.146021678371628 0.938181555571604 0.647058823529412 15.2 15 2 pancytopenia 0.0405632079416262 0.146021678371628 0.938181555571604 0.647058823529412 15.2 15 2 coloboma 0.0405632079416262 0.146021678371628 0.938181555571604 0.647058823529412 15.2 15 2 abnormal circulating chemokine level 0.0405632079416262 0.146021678371628 0.938181555571604 0.647058823529412 15.2 15 2 abnormal survival 0.0405632079416262 0.146021678371628 0.938181555571604 0.647058823529412 15.2 15 2 increased trabecular bone mass 0.0405632079416262 0.146021678371628 0.938181555571604 0.647058823529412 15.2 15 2 abnormal electroretinogram waveform feature 0.0405632079416262 0.146021678371628 0.938181555571604 0.647058823529412 15.2 15 2 deafness 1.42645361987654e-06 2.6283728736614e-05 0.937320048174385 0.646464646464647 15.2 15 2 increased mean corpuscular hemoglobin 1.42645361987654e-06 2.6283728736614e-05 0.937320048174385 0.646464646464647 15.2 15 2 retinal degeneration 2.17599933457704e-06 3.88014218262394e-05 0.936404696564839 0.645833333333333 15.2 15 2 abnormal kidney morphology 1.82316204777439e-10 7.13399477229182e-09 0.936232087404183 0.645714285714286 15.2 15 2 abnormal placenta morphology 1.72389495617947e-05 0.000243647085425933 0.936022334500093 0.645569620253165 15.2 15 2 lethargy 3.32027875524342e-06 5.75553547293938e-05 0.935430290012743 0.645161290322581 15.2 15 2 pericardial effusion 0.00013924125657161 0.00149940530615532 0.935430290012743 0.645161290322581 15.2 15 2 increased lung adenoma incidence 0.00656853991722777 0.0370924927221432 0.935430290012743 0.645161290322581 15.2 15 2 small cranium 0.00656853991722777 0.0370924927221432 0.935430290012743 0.645161290322581 15.2 15 2 abnormal ectoderm development 0.00116174532890412 0.0093690352161223 0.93439092302384 0.644444444444444 15.2 15 2 abnormal myocardial trabeculae morphology 0.00116174532890412 0.0093690352161223 0.93439092302384 0.644444444444444 15.2 15 2 abnormal cell migration 0.00116174532890412 0.0093690352161223 0.93439092302384 0.644444444444444 15.2 15 2 decreased osteoclast cell number 0.00116174532890412 0.0093690352161223 0.93439092302384 0.644444444444444 15.2 15 2 decreased bone mineral density 8.22036463788134e-15 5.45284187646129e-13 0.932089467548412 0.642857142857143 15.2 15 2 abnormal seminal vesicle morphology 0.000329426334725534 0.00320723290657442 0.932089467548412 0.642857142857143 15.2 15 2 abnormal muscle morphology 0.00180103836924479 0.0136379998279951 0.932089467548412 0.642857142857143 15.2 15 2 abnormal circulating cholesterol level 0.0103272418419052 0.052002052797043 0.932089467548412 0.642857142857143 15.2 15 2 abnormal respiration 0.0103272418419052 0.052002052797043 0.932089467548412 0.642857142857143 15.2 15 2 enhanced coordination 0.0103272418419052 0.052002052797043 0.932089467548412 0.642857142857143 15.2 15 2 increased triglyceride level 0.0103272418419052 0.052002052797043 0.932089467548412 0.642857142857143 15.2 15 2 abnormal kidney blood vessel morphology 0.0661513395856781 0.193859851904012 0.932089467548412 0.642857142857143 15.2 15 2 translucent skin 0.0661513395856781 0.193859851904012 0.932089467548412 0.642857142857143 15.2 15 2 irregularly shaped pupil 0.0661513395856781 0.193859851904012 0.932089467548412 0.642857142857143 15.2 15 2 increased aggression towards males 0.0661513395856781 0.193859851904012 0.932089467548412 0.642857142857143 15.2 15 2 abnormal pinna reflex 0.0661513395856781 0.193859851904012 0.932089467548412 0.642857142857143 15.2 15 2 absent visceral yolk sac blood islands 0.0661513395856781 0.193859851904012 0.932089467548412 0.642857142857143 15.2 15 2 abnormal endplate potential 0.0661513395856781 0.193859851904012 0.932089467548412 0.642857142857143 15.2 15 2 absent otoliths 0.0661513395856781 0.193859851904012 0.932089467548412 0.642857142857143 15.2 15 2 abnormal kidney medulla morphology 0.0661513395856781 0.193859851904012 0.932089467548412 0.642857142857143 15.2 15 2 decreased coping response 0.0661513395856781 0.193859851904012 0.932089467548412 0.642857142857143 15.2 15 2 intestinal obstruction 0.0661513395856781 0.193859851904012 0.932089467548412 0.642857142857143 15.2 15 2 failure of zygotic cell division 0.0661513395856781 0.193859851904012 0.932089467548412 0.642857142857143 15.2 15 2 abnormal uterus development 0.0661513395856781 0.193859851904012 0.932089467548412 0.642857142857143 15.2 15 2 abnormal decidualization 0.0661513395856781 0.193859851904012 0.932089467548412 0.642857142857143 15.2 15 2 enlarged stomach 0.0661513395856781 0.193859851904012 0.932089467548412 0.642857142857143 15.2 15 2 abnormal pancreas development 0.0661513395856781 0.193859851904012 0.932089467548412 0.642857142857143 15.2 15 2 decreased compact bone area 0.0661513395856781 0.193859851904012 0.932089467548412 0.642857142857143 15.2 15 2 abnormal pancreatic islet morphology 0.00050743157234189 0.00467494828222389 0.930135401578709 0.641509433962264 15.2 15 2 increased blood urea nitrogen level 1.1813983942691e-08 3.47778521389868e-07 0.929946733140254 0.641379310344828 15.2 15 2 abnormal heart looping 0.00279739091223271 0.0192756506763958 0.929433941999841 0.641025641025641 15.2 15 2 increased hepatocyte apoptosis 0.00279739091223271 0.0192756506763958 0.929433941999841 0.641025641025641 15.2 15 2 increased body length 0.000782474870925526 0.00666577479940838 0.927946847692641 0.64 15.2 15 2 impaired conditioned place preference behavior 0.0163077073585874 0.0740920950766869 0.927946847692641 0.64 15.2 15 2 abnormal hepatocyte morphology 7.0677048067038e-07 1.39531077037109e-05 0.927424355098219 0.63963963963964 15.2 15 2 heart right ventricle hypertrophy 0.00435429707738612 0.0272129243279905 0.926335828859841 0.638888888888889 15.2 15 2 renal hypoplasia 0.00435429707738612 0.0272129243279905 0.926335828859841 0.638888888888889 15.2 15 2 abnormal spermiogenesis 0.000342818225347054 0.0033310950607453 0.924947019521221 0.637931034482759 15.2 15 2 improved glucose tolerance 6.90581585530732e-11 2.88709528404655e-09 0.924691932091678 0.637755102040816 15.2 15 2 enlarged pericardium 0.00679453360475301 0.0380662214905926 0.92267442242166 0.636363636363636 15.2 15 2 belly spot 0.00679453360475301 0.0380662214905926 0.92267442242166 0.636363636363636 15.2 15 2 abnormal epidermis stratum basale morphology 0.00679453360475301 0.0380662214905926 0.92267442242166 0.636363636363636 15.2 15 2 decreased brown adipose tissue amount 0.00679453360475301 0.0380662214905926 0.92267442242166 0.636363636363636 15.2 15 2 dilated heart atrium 0.00679453360475301 0.0380662214905926 0.92267442242166 0.636363636363636 15.2 15 2 myeloid hyperplasia 0.00679453360475301 0.0380662214905926 0.92267442242166 0.636363636363636 15.2 15 2 short femur 1.28372295077805e-05 0.000192365110847012 0.92267442242166 0.636363636363636 15.2 15 2 abnormal rostral-caudal axis patterning 0.000526921971802543 0.00484553938949659 0.92267442242166 0.636363636363636 15.2 15 2 cochlear hair cell degeneration 0.00186763079010217 0.013921427443058 0.92267442242166 0.636363636363636 15.2 15 2 increased body size 0.0258892881752303 0.105486657388838 0.92267442242166 0.636363636363636 15.2 15 2 abnormal germ layer development 0.0258892881752303 0.105486657388838 0.92267442242166 0.636363636363636 15.2 15 2 testis hypoplasia 0.0258892881752303 0.105486657388838 0.92267442242166 0.636363636363636 15.2 15 2 abnormal vascular branching morphogenesis 0.0258892881752303 0.105486657388838 0.92267442242166 0.636363636363636 15.2 15 2 cleft upper lip 0.0258892881752303 0.105486657388838 0.92267442242166 0.636363636363636 15.2 15 2 abnormal sperm midpiece morphology 0.0258892881752303 0.105486657388838 0.92267442242166 0.636363636363636 15.2 15 2 embryonic lethality before implantation, incomplete penetrance 0.0258892881752303 0.105486657388838 0.92267442242166 0.636363636363636 15.2 15 2 premature suture closure 0.109686491723164 0.276298884214047 0.92267442242166 0.636363636363636 15.2 15 2 decreased atrioventricular cushion size 0.109686491723164 0.276298884214047 0.92267442242166 0.636363636363636 15.2 15 2 abnormal sebaceous gland morphology 0.109686491723164 0.276298884214047 0.92267442242166 0.636363636363636 15.2 15 2 abnormal food preference 0.109686491723164 0.276298884214047 0.92267442242166 0.636363636363636 15.2 15 2 abnormal hemoglobin 0.109686491723164 0.276298884214047 0.92267442242166 0.636363636363636 15.2 15 2 abnormal larynx morphology 0.109686491723164 0.276298884214047 0.92267442242166 0.636363636363636 15.2 15 2 retinal detachment 0.109686491723164 0.276298884214047 0.92267442242166 0.636363636363636 15.2 15 2 fused joints 0.109686491723164 0.276298884214047 0.92267442242166 0.636363636363636 15.2 15 2 abnormal frequency of paradoxical sleep 0.109686491723164 0.276298884214047 0.92267442242166 0.636363636363636 15.2 15 2 loss of cortex neurons 0.109686491723164 0.276298884214047 0.92267442242166 0.636363636363636 15.2 15 2 pharyngeal arch hypoplasia 0.109686491723164 0.276298884214047 0.92267442242166 0.636363636363636 15.2 15 2 abnormal Bruch membrane morphology 0.109686491723164 0.276298884214047 0.92267442242166 0.636363636363636 15.2 15 2 increased glycogen level 0.109686491723164 0.276298884214047 0.92267442242166 0.636363636363636 15.2 15 2 abnormal platelet aggregation 0.109686491723164 0.276298884214047 0.92267442242166 0.636363636363636 15.2 15 2 enhanced behavioral response to addictive substance 0.109686491723164 0.276298884214047 0.92267442242166 0.636363636363636 15.2 15 2 abnormal aorta smooth muscle morphology 0.109686491723164 0.276298884214047 0.92267442242166 0.636363636363636 15.2 15 2 decreased palatine bone horizontal plate size 0.109686491723164 0.276298884214047 0.92267442242166 0.636363636363636 15.2 15 2 common atrioventricular valve 0.109686491723164 0.276298884214047 0.92267442242166 0.636363636363636 15.2 15 2 abnormal extraembryonic ectoderm morphology 0.109686491723164 0.276298884214047 0.92267442242166 0.636363636363636 15.2 15 2 abnormal phrenic nerve innervation pattern to diaphragm 0.109686491723164 0.276298884214047 0.92267442242166 0.636363636363636 15.2 15 2 respiratory distress 1.20457994405787e-09 4.04917920384317e-08 0.921912511255333 0.635838150289017 15.2 15 2 abnormal intestine morphology 6.69914009649849e-05 0.000787901228843498 0.92089319766795 0.635135135135135 15.2 15 2 increased circulating aspartate transaminase level 0.000231547003979929 0.00237025996872459 0.920582190171271 0.634920634920635 15.2 15 2 abnormal vitelline vasculature morphology 7.65160147208851e-07 1.49281244406433e-05 0.92038206360819 0.634782608695652 15.2 15 2 no abnormal phenotype detected 9.13177762821838e-85 2.27152968501932e-81 0.920091389868154 0.634582132564842 15.2 15 2 abnormal definitive hematopoiesis 8.74759237215854e-06 0.000137284769878513 0.919839785179197 0.634408602150538 15.2 15 2 increased bone trabecula number 0.00289166014480536 0.0197338946781985 0.919459528963745 0.634146341463415 15.2 15 2 decreased lymphocyte cell number 2.35971404238477e-07 5.33617152766557e-06 0.917525569617968 0.6328125 15.2 15 2 abnormal long bone hypertrophic chondrocyte zone 0.00124815578201295 0.00991944890657259 0.917294396634945 0.63265306122449 15.2 15 2 increased circulating LDL cholesterol level 0.00124815578201295 0.00991944890657259 0.917294396634945 0.63265306122449 15.2 15 2 abnormal craniofacial development 0.00124815578201295 0.00991944890657259 0.917294396634945 0.63265306122449 15.2 15 2 decreased circulating alanine transaminase level 0.000156387643727785 0.00167190378889235 0.916859247490431 0.632352941176471 15.2 15 2 alopecia 9.05179719097456e-06 0.000141168310423506 0.915737020749317 0.631578947368421 15.2 15 2 hyporesponsive to tactile stimuli 0.00448474769411371 0.0274098523073903 0.915737020749317 0.631578947368421 15.2 15 2 decreased threshold for auditory brainstem response 0.00448474769411371 0.0274098523073903 0.915737020749317 0.631578947368421 15.2 15 2 abnormal nail morphology 0.0413761711178347 0.147525812605996 0.915737020749317 0.631578947368421 15.2 15 2 short vibrissae 0.0413761711178347 0.147525812605996 0.915737020749317 0.631578947368421 15.2 15 2 stereotypic behavior 0.0413761711178347 0.147525812605996 0.915737020749317 0.631578947368421 15.2 15 2 decreased tumor incidence 0.0413761711178347 0.147525812605996 0.915737020749317 0.631578947368421 15.2 15 2 increased liver adenoma incidence 0.0413761711178347 0.147525812605996 0.915737020749317 0.631578947368421 15.2 15 2 increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 0.0413761711178347 0.147525812605996 0.915737020749317 0.631578947368421 15.2 15 2 shortened RR interval 0.0413761711178347 0.147525812605996 0.915737020749317 0.631578947368421 15.2 15 2 right-sided stomach 0.0413761711178347 0.147525812605996 0.915737020749317 0.631578947368421 15.2 15 2 decreased B cell number 8.3342492876308e-11 3.45524085049694e-09 0.914996133192076 0.631067961165049 15.2 15 2 arrest of spermatogenesis 3.08135892974263e-05 0.000399212517590353 0.9148285514827 0.630952380952381 15.2 15 2 thymus hypoplasia 1.10219639927631e-07 2.63626302230751e-06 0.914078076871148 0.630434782608696 15.2 15 2 abnormal lung morphology 8.19674697841883e-07 1.59292250850132e-05 0.913813203478835 0.630252100840336 15.2 15 2 increased monocyte cell number 6.15496656136569e-06 0.000100581634433726 0.913447678197444 0.63 15.2 15 2 abnormal type II pneumocyte morphology 0.0166962358714594 0.0752079285619945 0.912910671919844 0.62962962962963 15.2 15 2 cryptorchism 0.0166962358714594 0.0752079285619945 0.912910671919844 0.62962962962963 15.2 15 2 abnormal palate morphology 0.0166962358714594 0.0752079285619945 0.912910671919844 0.62962962962963 15.2 15 2 abnormal skin appearance 0.0166962358714594 0.0752079285619945 0.912910671919844 0.62962962962963 15.2 15 2 decreased circulating fructosamine level 0.0166962358714594 0.0752079285619945 0.912910671919844 0.62962962962963 15.2 15 2 decreased circulating thyroxine level 0.00696881030047723 0.0383515832354803 0.911376368269558 0.628571428571429 15.2 15 2 abnormal heart ventricle morphology 7.13701456397795e-05 0.000837420930561092 0.910845263159844 0.628205128205128 15.2 15 2 abnormal bone mineralization 8.45306753864951e-07 1.62960723573839e-05 0.910691637714885 0.628099173553719 15.2 15 2 abnormal gluconeogenesis 0.00128230298529859 0.0101745731289641 0.909751811463374 0.627450980392157 15.2 15 2 increased sensitivity to xenobiotic induced morbidity/mortality 2.84439367098201e-06 5.00030336153198e-05 0.909493359244208 0.627272727272727 15.2 15 2 abnormal skin pigmentation 0.00458706968660032 0.0275702295038353 0.906198093449845 0.625 15.2 15 2 abnormal pancreatic beta cell morphology 0.00458706968660032 0.0275702295038353 0.906198093449845 0.625 15.2 15 2 cachexia 6.51499169116775e-06 0.000104893474639351 0.906198093449845 0.625 15.2 15 2 cochlear outer hair cell degeneration 0.000165362816579612 0.00175038300528419 0.906198093449845 0.625 15.2 15 2 kidney cortex cysts 0.0108523084058212 0.0541252477720531 0.906198093449845 0.625 15.2 15 2 abnormal serotonin level 0.0108523084058212 0.0541252477720531 0.906198093449845 0.625 15.2 15 2 failure of tooth eruption 0.0666985471636165 0.193859851904012 0.906198093449845 0.625 15.2 15 2 abnormal hair follicle orientation 0.0666985471636165 0.193859851904012 0.906198093449845 0.625 15.2 15 2 delayed hair appearance 0.0666985471636165 0.193859851904012 0.906198093449845 0.625 15.2 15 2 increased intestinal adenocarcinoma incidence 0.0666985471636165 0.193859851904012 0.906198093449845 0.625 15.2 15 2 abnormal epicardium morphology 0.0666985471636165 0.193859851904012 0.906198093449845 0.625 15.2 15 2 bowed radius 0.0666985471636165 0.193859851904012 0.906198093449845 0.625 15.2 15 2 decreased circulating triiodothyronine level 0.0666985471636165 0.193859851904012 0.906198093449845 0.625 15.2 15 2 kidney degeneration 0.0666985471636165 0.193859851904012 0.906198093449845 0.625 15.2 15 2 dilated respiratory conducting tubes 0.0666985471636165 0.193859851904012 0.906198093449845 0.625 15.2 15 2 abnormal pulmonary alveolus wall morphology 0.0666985471636165 0.193859851904012 0.906198093449845 0.625 15.2 15 2 embryonic lethality between somite formation and embryo turning, incomplete penetrance 0.0666985471636165 0.193859851904012 0.906198093449845 0.625 15.2 15 2 decreased adipocyte glucose uptake 0.0666985471636165 0.193859851904012 0.906198093449845 0.625 15.2 15 2 clubfoot 0.186561328491489 0.377331143963212 0.906198093449845 0.625 15.2 15 2 enlarged pituitary gland 0.186561328491489 0.377331143963212 0.906198093449845 0.625 15.2 15 2 abnormal vagus ganglion morphology 0.186561328491489 0.377331143963212 0.906198093449845 0.625 15.2 15 2 dry eyes 0.186561328491489 0.377331143963212 0.906198093449845 0.625 15.2 15 2 preneoplasia 0.186561328491489 0.377331143963212 0.906198093449845 0.625 15.2 15 2 abnormal hepatobiliary system morphology 0.186561328491489 0.377331143963212 0.906198093449845 0.625 15.2 15 2 abnormal pulmonary circulation 0.186561328491489 0.377331143963212 0.906198093449845 0.625 15.2 15 2 abnormal parturition 0.186561328491489 0.377331143963212 0.906198093449845 0.625 15.2 15 2 altered response to CNS ischemic injury 0.186561328491489 0.377331143963212 0.906198093449845 0.625 15.2 15 2 abnormal cellular cholesterol metabolism 0.186561328491489 0.377331143963212 0.906198093449845 0.625 15.2 15 2 decreased susceptibility to age related obesity 0.186561328491489 0.377331143963212 0.906198093449845 0.625 15.2 15 2 abnormal umbilical artery morphology 0.186561328491489 0.377331143963212 0.906198093449845 0.625 15.2 15 2 abnormal ovary development 0.186561328491489 0.377331143963212 0.906198093449845 0.625 15.2 15 2 abnormal thermosensation 0.186561328491489 0.377331143963212 0.906198093449845 0.625 15.2 15 2 lymph node inflammation 0.186561328491489 0.377331143963212 0.906198093449845 0.625 15.2 15 2 small frontal bone 0.186561328491489 0.377331143963212 0.906198093449845 0.625 15.2 15 2 absent cochlear microphonics 0.186561328491489 0.377331143963212 0.906198093449845 0.625 15.2 15 2 abnormal choroid pigmentation 0.186561328491489 0.377331143963212 0.906198093449845 0.625 15.2 15 2 increased circulating prolactin level 0.186561328491489 0.377331143963212 0.906198093449845 0.625 15.2 15 2 non-pigmented tail tip 0.186561328491489 0.377331143963212 0.906198093449845 0.625 15.2 15 2 abnormal circulating corticosterone level 0.186561328491489 0.377331143963212 0.906198093449845 0.625 15.2 15 2 abnormal ilium morphology 0.186561328491489 0.377331143963212 0.906198093449845 0.625 15.2 15 2 stomach epithelial hyperplasia 0.186561328491489 0.377331143963212 0.906198093449845 0.625 15.2 15 2 absent outer ear 0.186561328491489 0.377331143963212 0.906198093449845 0.625 15.2 15 2 enlarged inguinal lymph nodes 0.186561328491489 0.377331143963212 0.906198093449845 0.625 15.2 15 2 abnormal sphingomyelin level 0.186561328491489 0.377331143963212 0.906198093449845 0.625 15.2 15 2 abnormal frontonasal prominence morphology 0.186561328491489 0.377331143963212 0.906198093449845 0.625 15.2 15 2 skin fibrosis 0.186561328491489 0.377331143963212 0.906198093449845 0.625 15.2 15 2 decreased serotonin level 0.186561328491489 0.377331143963212 0.906198093449845 0.625 15.2 15 2 heart right ventricle hypoplasia 0.186561328491489 0.377331143963212 0.906198093449845 0.625 15.2 15 2 anomalous pulmonary venous connection 0.186561328491489 0.377331143963212 0.906198093449845 0.625 15.2 15 2 myocardial trabeculae hypoplasia 0.186561328491489 0.377331143963212 0.906198093449845 0.625 15.2 15 2 impaired mucociliary clearance 0.186561328491489 0.377331143963212 0.906198093449845 0.625 15.2 15 2 abnormal bronchus epithelium morphology 0.186561328491489 0.377331143963212 0.906198093449845 0.625 15.2 15 2 abnormal branching involved in ureteric bud morphogenesis 0.186561328491489 0.377331143963212 0.906198093449845 0.625 15.2 15 2 lethality during fetal growth through weaning, incomplete penetrance 0.186561328491489 0.377331143963212 0.906198093449845 0.625 15.2 15 2 abnormal heart echocardiography feature 0.186561328491489 0.377331143963212 0.906198093449845 0.625 15.2 15 2 abnormal umbilical vein topology 0.186561328491489 0.377331143963212 0.906198093449845 0.625 15.2 15 2 increased mammary gland apoptosis 0.186561328491489 0.377331143963212 0.906198093449845 0.625 15.2 15 2 decreased white adipose tissue mass 0.186561328491489 0.377331143963212 0.906198093449845 0.625 15.2 15 2 increased brain apoptosis 0.186561328491489 0.377331143963212 0.906198093449845 0.625 15.2 15 2 decreased basal metabolism 0.186561328491489 0.377331143963212 0.906198093449845 0.625 15.2 15 2 abnormal digestive system morphology 0.0263230044913562 0.106903630485304 0.906198093449845 0.625 15.2 15 2 abnormal foregut morphology 0.0263230044913562 0.106903630485304 0.906198093449845 0.625 15.2 15 2 abnormal enzyme/coenzyme activity 3.70978497001718e-08 9.76517472266427e-07 0.905043700974113 0.624203821656051 15.2 15 2 increased circulating bilirubin level 0.00131081000693326 0.0103512377531635 0.902778478002864 0.622641509433962 15.2 15 2 albuminuria 0.00303026566736953 0.0204831137162547 0.902170546367845 0.622222222222222 15.2 15 2 abnormal metabolism 0.00303026566736953 0.0204831137162547 0.902170546367845 0.622222222222222 15.2 15 2 increased erythroid progenitor cell number 0.00709703624998081 0.038714644017165 0.901299725377143 0.621621621621622 15.2 15 2 increased trabecular bone volume 0.00709703624998081 0.038714644017165 0.901299725377143 0.621621621621622 15.2 15 2 abnormal microglial cell morphology 0.0169419382609103 0.0756608104560401 0.899948451426053 0.620689655172414 15.2 15 2 abnormal interventricular septum morphology 0.00200795095273453 0.014668951526952 0.898948508702246 0.62 15.2 15 2 increased circulating chloride level 0.00200795095273453 0.014668951526952 0.898948508702246 0.62 15.2 15 2 testicular atrophy 0.00200795095273453 0.014668951526952 0.898948508702246 0.62 15.2 15 2 decreased respiratory quotient 0.00200795095273453 0.014668951526952 0.898948508702246 0.62 15.2 15 2 cataract 2.07819272804306e-06 3.71906792158784e-05 0.89870885300811 0.619834710743802 15.2 15 2 decreased susceptibility to hepatic steatosis 0.000583454309790472 0.00524439932190599 0.897567635416989 0.619047619047619 15.2 15 2 abnormal cartilage morphology 0.00466392053009129 0.0276953084718723 0.897567635416989 0.619047619047619 15.2 15 2 abnormal erythrocyte physiology 0.0417029763276004 0.147562096180521 0.897567635416989 0.619047619047619 15.2 15 2 lung hemorrhage 0.0109969792773146 0.0541252477720531 0.895536939409258 0.617647058823529 15.2 15 2 thin skin 0.0109969792773146 0.0541252477720531 0.895536939409258 0.617647058823529 15.2 15 2 abnormal endoderm development 0.0109969792773146 0.0541252477720531 0.895536939409258 0.617647058823529 15.2 15 2 abnormal bone remodeling 0.0109969792773146 0.0541252477720531 0.895536939409258 0.617647058823529 15.2 15 2 decreased hemoglobin content 4.39445670167551e-07 9.34291542343405e-06 0.894629607150485 0.617021276595745 15.2 15 2 abnormal tibia morphology 0.00307720147931708 0.020744007262334 0.894629607150485 0.617021276595745 15.2 15 2 decreased bone trabecula number 0.00307720147931708 0.020744007262334 0.894629607150485 0.617021276595745 15.2 15 2 decreased hematocrit 2.98119768555552e-07 6.56259225028261e-06 0.893784420936833 0.616438356164384 15.2 15 2 decreased percent body fat/body weight 0.000261350944355348 0.00262141320195133 0.893784420936833 0.616438356164384 15.2 15 2 decreased cardiac muscle contractility 1.58077482245736e-05 0.000225339677413334 0.892256584319847 0.615384615384615 15.2 15 2 increased circulating alanine transaminase level 0.000175259204835685 0.00182791309026737 0.892256584319847 0.615384615384615 15.2 15 2 impaired macrophage chemotaxis 0.0071845185451233 0.0390633658600966 0.892256584319847 0.615384615384615 15.2 15 2 absent teeth 0.108758297171482 0.276298884214047 0.892256584319847 0.615384615384615 15.2 15 2 absent common myeloid progenitor cells 0.108758297171482 0.276298884214047 0.892256584319847 0.615384615384615 15.2 15 2 absent trabeculae carneae 0.108758297171482 0.276298884214047 0.892256584319847 0.615384615384615 15.2 15 2 tight skin 0.108758297171482 0.276298884214047 0.892256584319847 0.615384615384615 15.2 15 2 abnormal digestion 0.108758297171482 0.276298884214047 0.892256584319847 0.615384615384615 15.2 15 2 abnormal lung interstitium morphology 0.108758297171482 0.276298884214047 0.892256584319847 0.615384615384615 15.2 15 2 dystrophic cardiac calcinosis 0.108758297171482 0.276298884214047 0.892256584319847 0.615384615384615 15.2 15 2 abnormal otolith morphology 0.108758297171482 0.276298884214047 0.892256584319847 0.615384615384615 15.2 15 2 abnormal bile duct development 0.108758297171482 0.276298884214047 0.892256584319847 0.615384615384615 15.2 15 2 decreased alcohol consumption 0.108758297171482 0.276298884214047 0.892256584319847 0.615384615384615 15.2 15 2 abnormal insulin secretion 0.108758297171482 0.276298884214047 0.892256584319847 0.615384615384615 15.2 15 2 decreased endocochlear potential 0.108758297171482 0.276298884214047 0.892256584319847 0.615384615384615 15.2 15 2 small pituitary gland 0.108758297171482 0.276298884214047 0.892256584319847 0.615384615384615 15.2 15 2 increased circulating thyroxine level 0.108758297171482 0.276298884214047 0.892256584319847 0.615384615384615 15.2 15 2 orthokeratosis 0.108758297171482 0.276298884214047 0.892256584319847 0.615384615384615 15.2 15 2 empty decidua capsularis 0.108758297171482 0.276298884214047 0.892256584319847 0.615384615384615 15.2 15 2 abnormal spleen morphology 2.86717504923856e-08 7.83747025822079e-07 0.89161559539433 0.614942528735632 15.2 15 2 abnormal liver morphology 1.94744970504713e-08 5.41260462715613e-07 0.891010415905993 0.614525139664804 15.2 15 2 abnormal retina morphology 1.26139880105792e-09 4.21171747333098e-08 0.890663268990704 0.614285714285714 15.2 15 2 abnormal pulmonary alveolus morphology 2.37959130512755e-05 0.000318238353306708 0.890048028418065 0.613861386138614 15.2 15 2 lethality, incomplete penetrance 0.00471785290600799 0.0277044001876108 0.889721764478029 0.613636363636364 15.2 15 2 hypoglycemia 5.31847218802918e-05 0.000644592474890004 0.888658775512106 0.612903225806452 15.2 15 2 abnormal nose morphology 0.0170682336823345 0.076071393893819 0.888658775512106 0.612903225806452 15.2 15 2 pale kidney 0.0170682336823345 0.076071393893819 0.888658775512106 0.612903225806452 15.2 15 2 female infertility 1.19567448251459e-11 5.88958470347533e-10 0.888482942750825 0.612781954887218 15.2 15 2 decreased tumor growth/size 0.00205838156578298 0.0147556891783434 0.886060358039848 0.611111111111111 15.2 15 2 decreased platelet aggregation 0.00205838156578298 0.0147556891783434 0.886060358039848 0.611111111111111 15.2 15 2 decreased insulin secretion 8.00769268266163e-05 0.000922182201301889 0.886060358039848 0.611111111111111 15.2 15 2 head tilt 0.0110773310796204 0.0541252477720531 0.886060358039848 0.611111111111111 15.2 15 2 cortical renal glomerulopathies 0.0664651064533096 0.193859851904012 0.886060358039848 0.611111111111111 15.2 15 2 abnormal mammary gland morphology 0.0664651064533096 0.193859851904012 0.886060358039848 0.611111111111111 15.2 15 2 abnormal redox activity 0.0664651064533096 0.193859851904012 0.886060358039848 0.611111111111111 15.2 15 2 increased circulating glycerol level 0.0664651064533096 0.193859851904012 0.886060358039848 0.611111111111111 15.2 15 2 decreased activity of thyroid 0.0664651064533096 0.193859851904012 0.886060358039848 0.611111111111111 15.2 15 2 abnormal neutrophil morphology 0.0664651064533096 0.193859851904012 0.886060358039848 0.611111111111111 15.2 15 2 jerky movement 0.0664651064533096 0.193859851904012 0.886060358039848 0.611111111111111 15.2 15 2 decreased lactate dehydrogenase level 0.0664651064533096 0.193859851904012 0.886060358039848 0.611111111111111 15.2 15 2 increased effector memory CD4-positive, alpha-beta T cell number 0.0664651064533096 0.193859851904012 0.886060358039848 0.611111111111111 15.2 15 2 increased effector memory CD8-positive, alpha-beta T cell number 0.0664651064533096 0.193859851904012 0.886060358039848 0.611111111111111 15.2 15 2 abnormal aerobic respiration 0.0664651064533096 0.193859851904012 0.886060358039848 0.611111111111111 15.2 15 2 decreased fluid intake 0.0664651064533096 0.193859851904012 0.886060358039848 0.611111111111111 15.2 15 2 increased adipocyte glucose uptake 0.0664651064533096 0.193859851904012 0.886060358039848 0.611111111111111 15.2 15 2 increased hemoglobin content 0.00136587080898639 0.0107011138184367 0.88469508784256 0.610169491525424 15.2 15 2 Leydig cell hyperplasia 0.00723614709565496 0.0391970407848824 0.884095700926678 0.609756097560976 15.2 15 2 palatal shelves fail to meet at midline 0.00723614709565496 0.0391970407848824 0.884095700926678 0.609756097560976 15.2 15 2 spleen hypoplasia 2.44018357252807e-05 0.00032422508135747 0.88375890256442 0.60952380952381 15.2 15 2 decreased circulating LDL cholesterol level 0.00090856590239947 0.00754610244480361 0.883543141113599 0.609375 15.2 15 2 abnormal tooth morphology 0.00090856590239947 0.00754610244480361 0.883543141113599 0.609375 15.2 15 2 abnormal forelimb morphology 0.00475127688656015 0.0277436649185877 0.882558143185936 0.608695652173913 15.2 15 2 embryonic lethality between implantation and placentation, complete penetrance 0.00475127688656015 0.0277436649185877 0.882558143185936 0.608695652173913 15.2 15 2 fragile skeleton 0.0416630686857134 0.147525812605996 0.882558143185936 0.608695652173913 15.2 15 2 abnormal blood vessel physiology 0.0416630686857134 0.147525812605996 0.882558143185936 0.608695652173913 15.2 15 2 abnormal retinal cone cell morphology 0.0416630686857134 0.147525812605996 0.882558143185936 0.608695652173913 15.2 15 2 abnormal nasal cavity morphology 0.0416630686857134 0.147525812605996 0.882558143185936 0.608695652173913 15.2 15 2 abnormal sacral vertebrae morphology 0.0416630686857134 0.147525812605996 0.882558143185936 0.608695652173913 15.2 15 2 abnormal crista ampullaris morphology 0.0416630686857134 0.147525812605996 0.882558143185936 0.608695652173913 15.2 15 2 abnormal B cell morphology 0.0416630686857134 0.147525812605996 0.882558143185936 0.608695652173913 15.2 15 2 abnormal palatal shelf fusion at midline 0.0416630686857134 0.147525812605996 0.882558143185936 0.608695652173913 15.2 15 2 decreased effector memory CD8-positive, alpha-beta T cell number 0.0416630686857134 0.147525812605996 0.882558143185936 0.608695652173913 15.2 15 2 abnormal vertebral artery topology 0.0416630686857134 0.147525812605996 0.882558143185936 0.608695652173913 15.2 15 2 abnormal myocardial fiber morphology 5.43932078214267e-05 0.000655220844822271 0.881908247646034 0.608247422680412 15.2 15 2 increased lung adenocarcinoma incidence 0.00313270530226025 0.0208358407469849 0.881322067355143 0.607843137254902 15.2 15 2 cochlear inner hair cell degeneration 0.00313270530226025 0.0208358407469849 0.881322067355143 0.607843137254902 15.2 15 2 decreased food intake 0.000270536933890832 0.00269723696614607 0.880962197176558 0.607594936708861 15.2 15 2 lymphoid hyperplasia 0.0265392266444067 0.10695084609214 0.880306719351278 0.607142857142857 15.2 15 2 abnormal ovulation 0.0265392266444067 0.10695084609214 0.880306719351278 0.607142857142857 15.2 15 2 abnormal renal tubule epithelium morphology 0.0265392266444067 0.10695084609214 0.880306719351278 0.607142857142857 15.2 15 2 increased osteoblast cell number 0.0170950388690029 0.076071393893819 0.878737545163486 0.606060606060606 15.2 15 2 cardiovascular system phenotype 0.0170950388690029 0.076071393893819 0.878737545163486 0.606060606060606 15.2 15 2 decreased total retina thickness 0.011102545368977 0.0541252477720531 0.877581311551429 0.605263157894737 15.2 15 2 increased circulating creatinine level 0.000182407167302511 0.00189452120528182 0.876693969477059 0.604651162790698 15.2 15 2 kidney failure 0.00725637679655814 0.0391970407848824 0.876693969477059 0.604651162790698 15.2 15 2 abnormal double-strand DNA break repair 0.00725637679655814 0.0391970407848824 0.876693969477059 0.604651162790698 15.2 15 2 enlarged spleen 3.02101919306734e-11 1.35401535905496e-09 0.870957056482351 0.600694444444444 15.2 15 2 abnormal vascular regression 0.065692200010074 0.193859851904012 0.869950169711851 0.6 15.2 15 2 abnormal fibula morphology 0.065692200010074 0.193859851904012 0.869950169711851 0.6 15.2 15 2 abnormal hyoid bone morphology 0.065692200010074 0.193859851904012 0.869950169711851 0.6 15.2 15 2 abnormal lens epithelium morphology 0.065692200010074 0.193859851904012 0.869950169711851 0.6 15.2 15 2 abnormal optic stalk morphology 0.065692200010074 0.193859851904012 0.869950169711851 0.6 15.2 15 2 abnormal heart electrocardiography waveform feature 0.065692200010074 0.193859851904012 0.869950169711851 0.6 15.2 15 2 increased cranium width 0.18020242772012 0.377331143963212 0.869950169711851 0.6 15.2 15 2 jaundice 0.18020242772012 0.377331143963212 0.869950169711851 0.6 15.2 15 2 small petrosal ganglion 0.18020242772012 0.377331143963212 0.869950169711851 0.6 15.2 15 2 abnormal prostate gland epithelium morphology 0.18020242772012 0.377331143963212 0.869950169711851 0.6 15.2 15 2 abnormal pituitary secretion 0.18020242772012 0.377331143963212 0.869950169711851 0.6 15.2 15 2 abnormal respiratory mechanics 0.18020242772012 0.377331143963212 0.869950169711851 0.6 15.2 15 2 abnormal PNS synaptic transmission 0.18020242772012 0.377331143963212 0.869950169711851 0.6 15.2 15 2 abnormal primordial germ cell migration 0.18020242772012 0.377331143963212 0.869950169711851 0.6 15.2 15 2 delayed dark adaptation 0.18020242772012 0.377331143963212 0.869950169711851 0.6 15.2 15 2 peritoneal inflammation 0.18020242772012 0.377331143963212 0.869950169711851 0.6 15.2 15 2 abnormal hypaxial muscle morphology 0.18020242772012 0.377331143963212 0.869950169711851 0.6 15.2 15 2 abnormal glial cell physiology 0.18020242772012 0.377331143963212 0.869950169711851 0.6 15.2 15 2 increased atrioventricular cushion size 0.18020242772012 0.377331143963212 0.869950169711851 0.6 15.2 15 2 abnormal ear physiology 0.18020242772012 0.377331143963212 0.869950169711851 0.6 15.2 15 2 abnormal placental transport 0.18020242772012 0.377331143963212 0.869950169711851 0.6 15.2 15 2 abnormal cochlear inner hair cell physiology 0.18020242772012 0.377331143963212 0.869950169711851 0.6 15.2 15 2 tachypnea 0.18020242772012 0.377331143963212 0.869950169711851 0.6 15.2 15 2 increased serotonin level 0.18020242772012 0.377331143963212 0.869950169711851 0.6 15.2 15 2 umbilical hernia 0.18020242772012 0.377331143963212 0.869950169711851 0.6 15.2 15 2 increased T-helper 17 cell number 0.18020242772012 0.377331143963212 0.869950169711851 0.6 15.2 15 2 abnormal left subclavian artery morphology 0.18020242772012 0.377331143963212 0.869950169711851 0.6 15.2 15 2 abnormal inferior vena cava valve morphology 0.18020242772012 0.377331143963212 0.869950169711851 0.6 15.2 15 2 abnormal adaptive thermogenesis 0.18020242772012 0.377331143963212 0.869950169711851 0.6 15.2 15 2 weight loss 2.2820092899666e-07 5.1840165377095e-06 0.869950169711851 0.6 15.2 15 2 increased erythrocyte cell number 0.00208228246841551 0.0148841311499528 0.869950169711851 0.6 15.2 15 2 muscular ventricular septal defect 0.00208228246841551 0.0148841311499528 0.869950169711851 0.6 15.2 15 2 abnormal microglial cell physiology 0.0264054393966947 0.10695084609214 0.869950169711851 0.6 15.2 15 2 abnormal brain vasculature morphology 0.0264054393966947 0.10695084609214 0.869950169711851 0.6 15.2 15 2 decreased chondrocyte number 0.106724069382292 0.276298884214047 0.869950169711851 0.6 15.2 15 2 interdigital webbing 0.106724069382292 0.276298884214047 0.869950169711851 0.6 15.2 15 2 decreased hepatocyte number 0.106724069382292 0.276298884214047 0.869950169711851 0.6 15.2 15 2 decreased salivation 0.106724069382292 0.276298884214047 0.869950169711851 0.6 15.2 15 2 abnormal epidermis stratum spinosum morphology 0.106724069382292 0.276298884214047 0.869950169711851 0.6 15.2 15 2 no suckling reflex 0.106724069382292 0.276298884214047 0.869950169711851 0.6 15.2 15 2 abnormal lymph node B cell domain morphology 0.106724069382292 0.276298884214047 0.869950169711851 0.6 15.2 15 2 abnormal glial cell morphology 0.106724069382292 0.276298884214047 0.869950169711851 0.6 15.2 15 2 abnormal Muller cell morphology 0.106724069382292 0.276298884214047 0.869950169711851 0.6 15.2 15 2 decreased thymocyte apoptosis 0.106724069382292 0.276298884214047 0.869950169711851 0.6 15.2 15 2 absent chorion 0.106724069382292 0.276298884214047 0.869950169711851 0.6 15.2 15 2 ostium primum atrial septal defect 0.106724069382292 0.276298884214047 0.869950169711851 0.6 15.2 15 2 bicuspid aortic valve 0.106724069382292 0.276298884214047 0.869950169711851 0.6 15.2 15 2 decreased trabecular bone mass 0.106724069382292 0.276298884214047 0.869950169711851 0.6 15.2 15 2 abnormal platelet physiology 0.0031449397158644 0.0208892858296734 0.869950169711851 0.6 15.2 15 2 decreased circulating alkaline phosphatase level 0.00476541848084005 0.0277936189240085 0.869950169711851 0.6 15.2 15 2 abnormal ovarian follicle morphology 0.00724923376396567 0.0391970407848824 0.869950169711851 0.6 15.2 15 2 cardiomyopathy 0.00724923376396567 0.0391970407848824 0.869950169711851 0.6 15.2 15 2 abnormal egg cylinder morphology 0.0413459501905095 0.147525812605996 0.869950169711851 0.6 15.2 15 2 abnormal keratinocyte physiology 0.0413459501905095 0.147525812605996 0.869950169711851 0.6 15.2 15 2 increased liver glycogen level 0.0413459501905095 0.147525812605996 0.869950169711851 0.6 15.2 15 2 decreased compact bone thickness 0.00138103898835149 0.0107859795401078 0.865622059414777 0.597014925373134 15.2 15 2 absent corpus luteum 0.00475011809965657 0.0277436649185877 0.864373566059852 0.596153846153846 15.2 15 2 abnormal skin condition 0.00475011809965657 0.0277436649185877 0.864373566059852 0.596153846153846 15.2 15 2 increased circulating glucose level 5.23514540677547e-06 8.68161613290266e-05 0.863780310352192 0.595744680851064 15.2 15 2 skin edema 0.011018833221484 0.0541252477720531 0.863045803285566 0.595238095238095 15.2 15 2 abnormal spleen white pulp morphology 0.011018833221484 0.0541252477720531 0.863045803285566 0.595238095238095 15.2 15 2 abnormal eye electrophysiology 2.52493496088881e-05 0.000333197650674319 0.862760498887786 0.59504132231405 15.2 15 2 abnormal myocardium layer morphology 0.000612215038905597 0.00545836885045761 0.862608818068713 0.594936708860759 15.2 15 2 abnormal angiogenesis 0.000917168649897335 0.0076048567220654 0.862112780795528 0.594594594594595 15.2 15 2 increased white adipose tissue amount 0.0169150968297585 0.0756088110764136 0.862112780795528 0.594594594594595 15.2 15 2 abnormal long bone metaphysis morphology 0.0169150968297585 0.0756088110764136 0.862112780795528 0.594594594594595 15.2 15 2 abnormal branching of the mammary ductal tree 0.0169150968297585 0.0756088110764136 0.862112780795528 0.594594594594595 15.2 15 2 impaired skeletal muscle contractility 0.0169150968297585 0.0756088110764136 0.862112780795528 0.594594594594595 15.2 15 2 increased insulin secretion 0.0169150968297585 0.0756088110764136 0.862112780795528 0.594594594594595 15.2 15 2 abnormal respiratory electron transport chain 0.0169150968297585 0.0756088110764136 0.862112780795528 0.594594594594595 15.2 15 2 increased dopamine level 0.0261530475480079 0.106387090393573 0.860888188777353 0.59375 15.2 15 2 abnormal diaphragm morphology 0.0261530475480079 0.106387090393573 0.860888188777353 0.59375 15.2 15 2 abnormal small intestine morphology 0.00472227766011939 0.0277044001876108 0.859210044159853 0.592592592592593 15.2 15 2 abnormal osteoblast physiology 0.00472227766011939 0.0277044001876108 0.859210044159853 0.592592592592593 15.2 15 2 increased sarcoma incidence 0.00716691766500044 0.0390103012947234 0.858114112981077 0.591836734693878 15.2 15 2 increased fluid intake 0.00716691766500044 0.0390103012947234 0.858114112981077 0.591836734693878 15.2 15 2 corneal opacity 0.00136946619171838 0.0107124124273568 0.857697350420135 0.591549295774648 15.2 15 2 increased T cell number 0.000406041630940669 0.00381142851684874 0.856769106534399 0.590909090909091 15.2 15 2 abnormal gametogenesis 0.0109231335273527 0.0541252477720531 0.856769106534399 0.590909090909091 15.2 15 2 abnormal astrocyte morphology 0.0109231335273527 0.0541252477720531 0.856769106534399 0.590909090909091 15.2 15 2 abnormal enterocyte morphology 0.0645449703254685 0.193859851904012 0.856769106534399 0.590909090909091 15.2 15 2 abnormal oogenesis 0.0645449703254685 0.193859851904012 0.856769106534399 0.590909090909091 15.2 15 2 aphakia 0.0645449703254685 0.193859851904012 0.856769106534399 0.590909090909091 15.2 15 2 abnormal retinal outer plexiform layer morphology 0.0645449703254685 0.193859851904012 0.856769106534399 0.590909090909091 15.2 15 2 decreased circulating estradiol level 0.0645449703254685 0.193859851904012 0.856769106534399 0.590909090909091 15.2 15 2 abnormal mesenteric lymph node morphology 0.0645449703254685 0.193859851904012 0.856769106534399 0.590909090909091 15.2 15 2 failure of palatal shelf elevation 0.0645449703254685 0.193859851904012 0.856769106534399 0.590909090909091 15.2 15 2 enlarged heart 1.49618179194763e-08 4.30260370805749e-07 0.856200957259508 0.59051724137931 15.2 15 2 abnormal long bone morphology 0.00310044001671682 0.0208089863002979 0.855688691519853 0.590163934426229 15.2 15 2 increased osteoclast cell number 0.00310044001671682 0.0208089863002979 0.855688691519853 0.590163934426229 15.2 15 2 increased urine protein level 0.000907460630085456 0.00754610244480361 0.855079226639853 0.58974358974359 15.2 15 2 small lens 0.0167347089282669 0.0752079285619945 0.855079226639853 0.58974358974359 15.2 15 2 decreased B-1 B cell number 0.0167347089282669 0.0752079285619945 0.855079226639853 0.58974358974359 15.2 15 2 abnormal response to injury 0.0167347089282669 0.0752079285619945 0.855079226639853 0.58974358974359 15.2 15 2 decreased trabecular bone volume 0.0167347089282669 0.0752079285619945 0.855079226639853 0.58974358974359 15.2 15 2 thin ventricular wall 0.000403496943608602 0.00379470187987296 0.853839981383854 0.588888888888889 15.2 15 2 cardiac fibrosis 0.000602341495671537 0.00537998014536068 0.852892323246913 0.588235294117647 15.2 15 2 decreased osteoblast cell number 0.025806552571415 0.105486657388838 0.852892323246913 0.588235294117647 15.2 15 2 hydroureter 0.104034746052174 0.274855835774071 0.852892323246913 0.588235294117647 15.2 15 2 hyperlipidemia 0.104034746052174 0.274855835774071 0.852892323246913 0.588235294117647 15.2 15 2 abnormal duodenum morphology 0.104034746052174 0.274855835774071 0.852892323246913 0.588235294117647 15.2 15 2 increased circulating magnesium level 0.104034746052174 0.274855835774071 0.852892323246913 0.588235294117647 15.2 15 2 abnormal renal glomerulus morphology 0.000120579042624493 0.00133603727629589 0.851327383204258 0.587155963302752 15.2 15 2 abnormal inner ear morphology 0.0107989619581735 0.0541035606665793 0.851038209500724 0.58695652173913 15.2 15 2 abnormal retinal pigmentation 0.000597296089815963 0.00534451087560147 0.849951315235716 0.586206896551724 15.2 15 2 glomerulosclerosis 0.00463514804987946 0.0276166006564674 0.849951315235716 0.586206896551724 15.2 15 2 focal hair loss 0.0401353851876934 0.145322810268395 0.849951315235716 0.586206896551724 15.2 15 2 enlarged epididymis 0.0401353851876934 0.145322810268395 0.849951315235716 0.586206896551724 15.2 15 2 polychromatophilia 0.0401353851876934 0.145322810268395 0.849951315235716 0.586206896551724 15.2 15 2 scaly skin 0.016508284403147 0.0747984653056979 0.848731872889611 0.585365853658537 15.2 15 2 arrested B cell differentiation 0.016508284403147 0.0747984653056979 0.848731872889611 0.585365853658537 15.2 15 2 abnormal lipid homeostasis 3.60833549456118e-05 0.000457945639934742 0.847643755103855 0.584615384615385 15.2 15 2 increased bone mineral density 0.000118521497967064 0.00131617065264764 0.846854147507112 0.584070796460177 15.2 15 2 abnormal cardiovascular system morphology 0.0106509890796004 0.0534159986602945 0.845784887219855 0.583333333333333 15.2 15 2 abnormal lymph node morphology 0.0106509890796004 0.0534159986602945 0.845784887219855 0.583333333333333 15.2 15 2 abnormal osteoclast morphology 0.0106509890796004 0.0534159986602945 0.845784887219855 0.583333333333333 15.2 15 2 abnormal systemic arterial blood pressure 0.0253858950707009 0.104117747713716 0.845784887219855 0.583333333333333 15.2 15 2 abnormal epidermis stratum granulosum morphology 0.0253858950707009 0.104117747713716 0.845784887219855 0.583333333333333 15.2 15 2 abnormal adrenal gland morphology 0.0631391585578133 0.193859851904012 0.845784887219855 0.583333333333333 15.2 15 2 abnormal vasodilation 0.0631391585578133 0.193859851904012 0.845784887219855 0.583333333333333 15.2 15 2 abnormal primitive streak formation 0.0631391585578133 0.193859851904012 0.845784887219855 0.583333333333333 15.2 15 2 prolonged QT interval 0.0631391585578133 0.193859851904012 0.845784887219855 0.583333333333333 15.2 15 2 abnormal mineral level 0.173002162831427 0.377331143963212 0.845784887219855 0.583333333333333 15.2 15 2 mesocardia 0.173002162831427 0.377331143963212 0.845784887219855 0.583333333333333 15.2 15 2 abnormal superior cervical ganglion morphology 0.173002162831427 0.377331143963212 0.845784887219855 0.583333333333333 15.2 15 2 abnormal pilomotor reflex 0.173002162831427 0.377331143963212 0.845784887219855 0.583333333333333 15.2 15 2 increased litter size 0.173002162831427 0.377331143963212 0.845784887219855 0.583333333333333 15.2 15 2 abnormal gastrocnemius morphology 0.173002162831427 0.377331143963212 0.845784887219855 0.583333333333333 15.2 15 2 decreased circulating ketone body level 0.173002162831427 0.377331143963212 0.845784887219855 0.583333333333333 15.2 15 2 delayed somite formation 0.173002162831427 0.377331143963212 0.845784887219855 0.583333333333333 15.2 15 2 abnormal nucleotide metabolism 0.173002162831427 0.377331143963212 0.845784887219855 0.583333333333333 15.2 15 2 abnormal rostral-caudal body axis extension 0.173002162831427 0.377331143963212 0.845784887219855 0.583333333333333 15.2 15 2 increased hepatocyte proliferation 0.173002162831427 0.377331143963212 0.845784887219855 0.583333333333333 15.2 15 2 vestibular saccular macula degeneration 0.173002162831427 0.377331143963212 0.845784887219855 0.583333333333333 15.2 15 2 bowed ulna 0.173002162831427 0.377331143963212 0.845784887219855 0.583333333333333 15.2 15 2 abnormal cochlear outer hair cell physiology 0.173002162831427 0.377331143963212 0.845784887219855 0.583333333333333 15.2 15 2 abnormal palatine bone morphology 0.173002162831427 0.377331143963212 0.845784887219855 0.583333333333333 15.2 15 2 abnormal patella morphology 0.173002162831427 0.377331143963212 0.845784887219855 0.583333333333333 15.2 15 2 hydrometra 0.173002162831427 0.377331143963212 0.845784887219855 0.583333333333333 15.2 15 2 persistent right dorsal aorta 0.173002162831427 0.377331143963212 0.845784887219855 0.583333333333333 15.2 15 2 abnormal respiratory motile cilium morphology 0.173002162831427 0.377331143963212 0.845784887219855 0.583333333333333 15.2 15 2 small ovary 0.00058505359269504 0.00524439932190599 0.84445712444557 0.582417582417582 15.2 15 2 abnormal B cell differentiation 0.00058505359269504 0.00524439932190599 0.84445712444557 0.582417582417582 15.2 15 2 decreased circulating calcium level 0.00691683479995238 0.038230861098513 0.843588043356946 0.581818181818182 15.2 15 2 abnormal blood circulation 0.0162444671449919 0.0738722340460099 0.842974970651018 0.581395348837209 15.2 15 2 decreased oxygen consumption 0.0162444671449919 0.0738722340460099 0.842974970651018 0.581395348837209 15.2 15 2 osteopetrosis 0.0393338780781162 0.142732343864791 0.841887261011469 0.580645161290323 15.2 15 2 abnormal cranial ganglia morphology 0.0393338780781162 0.142732343864791 0.841887261011469 0.580645161290323 15.2 15 2 absent mature ovarian follicles 0.0393338780781162 0.142732343864791 0.841887261011469 0.580645161290323 15.2 15 2 abnormal body temperature homeostasis 0.0393338780781162 0.142732343864791 0.841887261011469 0.580645161290323 15.2 15 2 decreased neuronal precursor cell number 0.0393338780781162 0.142732343864791 0.841887261011469 0.580645161290323 15.2 15 2 decreased double-negative T cell number 0.0393338780781162 0.142732343864791 0.841887261011469 0.580645161290323 15.2 15 2 hyperkeratosis 0.0029593438716332 0.0200582231081406 0.840531564938986 0.579710144927536 15.2 15 2 abnormal coat appearance 0.0029593438716332 0.0200582231081406 0.840531564938986 0.579710144927536 15.2 15 2 thrombocytopenia 2.3153074859694e-05 0.000310475869075412 0.839951887997649 0.579310344827586 15.2 15 2 abnormal cardiovascular system physiology 5.11165073598012e-05 0.000624827086277668 0.83942560235354 0.578947368421053 15.2 15 2 abnormal facial morphology 0.00680914988374842 0.0381051976059037 0.83942560235354 0.578947368421053 15.2 15 2 abnormal triglyceride level 0.100962392539588 0.272982555915461 0.83942560235354 0.578947368421053 15.2 15 2 irregular coat pigmentation 0.100962392539588 0.272982555915461 0.83942560235354 0.578947368421053 15.2 15 2 small superior vagus ganglion 0.100962392539588 0.272982555915461 0.83942560235354 0.578947368421053 15.2 15 2 increased susceptibility to ischemic brain injury 0.100962392539588 0.272982555915461 0.83942560235354 0.578947368421053 15.2 15 2 abnormal optic vesicle formation 0.100962392539588 0.272982555915461 0.83942560235354 0.578947368421053 15.2 15 2 oliguria 0.100962392539588 0.272982555915461 0.83942560235354 0.578947368421053 15.2 15 2 abnormal osteoclast physiology 0.00444527625689303 0.0273645494424691 0.838233236441106 0.578125 15.2 15 2 abnormal ovary morphology 0.00291400469323324 0.0198319744854109 0.837275984933941 0.577464788732394 15.2 15 2 abnormal skeletal muscle fiber morphology 0.00291400469323324 0.0198319744854109 0.837275984933941 0.577464788732394 15.2 15 2 abnormal hair growth 0.0102993401231131 0.052002052797043 0.836490547799857 0.576923076923077 15.2 15 2 abnormal female meiosis 0.0102993401231131 0.052002052797043 0.836490547799857 0.576923076923077 15.2 15 2 abnormal tectorial membrane morphology 0.0615574240704653 0.193859851904012 0.836490547799857 0.576923076923077 15.2 15 2 abnormal erythrocyte osmotic lysis 0.0615574240704653 0.193859851904012 0.836490547799857 0.576923076923077 15.2 15 2 abnormal aorta morphology 0.0384460593266573 0.141053941851121 0.834800667905312 0.575757575757576 15.2 15 2 increased cardiomyocyte apoptosis 0.0384460593266573 0.141053941851121 0.834800667905312 0.575757575757576 15.2 15 2 decreased sensitivity to xenobiotic induced morbidity/mortality 0.0384460593266573 0.141053941851121 0.834800667905312 0.575757575757576 15.2 15 2 abnormal retinal pigment epithelium morphology 0.00188533960694482 0.013921427443058 0.833702245973857 0.575 15.2 15 2 abnormal hair follicle morphology 0.00643827828448178 0.0364396296533525 0.828523971154144 0.571428571428571 15.2 15 2 thick pulmonary interalveolar septum 0.0374963123432074 0.137874467041727 0.828523971154144 0.571428571428571 15.2 15 2 abnormal artery morphology 0.0374963123432074 0.137874467041727 0.828523971154144 0.571428571428571 15.2 15 2 increased circulating serum albumin level 0.0374963123432074 0.137874467041727 0.828523971154144 0.571428571428571 15.2 15 2 increased red blood cell distribution width 0.0374963123432074 0.137874467041727 0.828523971154144 0.571428571428571 15.2 15 2 corneal vascularization 0.059859694432943 0.193859851904012 0.828523971154144 0.571428571428571 15.2 15 2 abnormal mitotic spindle morphology 0.059859694432943 0.193859851904012 0.828523971154144 0.571428571428571 15.2 15 2 abnormal olfactory system physiology 0.165567573952553 0.367720537239118 0.828523971154144 0.571428571428571 15.2 15 2 decreased vascular permeability 0.165567573952553 0.367720537239118 0.828523971154144 0.571428571428571 15.2 15 2 abnormal ventral body wall morphology 0.165567573952553 0.367720537239118 0.828523971154144 0.571428571428571 15.2 15 2 abnormal sagittal suture morphology 0.165567573952553 0.367720537239118 0.828523971154144 0.571428571428571 15.2 15 2 abnormal glucose tolerance 0.165567573952553 0.367720537239118 0.828523971154144 0.571428571428571 15.2 15 2 decreased response to antigen 0.165567573952553 0.367720537239118 0.828523971154144 0.571428571428571 15.2 15 2 increased food intake 0.00181850881295416 0.0136888101075298 0.828523971154144 0.571428571428571 15.2 15 2 decreased circulating creatinine level 0.0152964176324005 0.0700733680673962 0.828523971154144 0.571428571428571 15.2 15 2 abnormal salivary gland morphology 0.0976778315867055 0.265110317590758 0.828523971154144 0.571428571428571 15.2 15 2 liver degeneration 0.0976778315867055 0.265110317590758 0.828523971154144 0.571428571428571 15.2 15 2 decreased cochlear outer hair cell number 0.0976778315867055 0.265110317590758 0.828523971154144 0.571428571428571 15.2 15 2 increased keratinocyte proliferation 0.0976778315867055 0.265110317590758 0.828523971154144 0.571428571428571 15.2 15 2 abnormal heart left ventricle morphology 0.00412369201968604 0.0262009805848506 0.825647151809858 0.569444444444444 15.2 15 2 increased brown adipose tissue amount 0.0365038177619378 0.135724530067707 0.822925836213913 0.567567567567568 15.2 15 2 abnormal hair follicle development 0.0365038177619378 0.135724530067707 0.822925836213913 0.567567567567568 15.2 15 2 internal hemorrhage 0.00616474422128626 0.0350109617590173 0.822340956444038 0.567164179104478 15.2 15 2 abnormal heart morphology 7.45038888136726e-07 1.45927892459851e-05 0.822247274402976 0.567099567099567 15.2 15 2 liver hemorrhage 0.0580899296836149 0.191135846677238 0.821619604727859 0.566666666666667 15.2 15 2 abnormal cellular respiration 0.0580899296836149 0.191135846677238 0.821619604727859 0.566666666666667 15.2 15 2 abnormal placenta development 0.0145848978114084 0.0670608748722338 0.820707707275331 0.566037735849057 15.2 15 2 failure of embryo implantation 0.0942914424571501 0.256759674999629 0.819518275815512 0.565217391304348 15.2 15 2 decreased epididymis weight 0.0942914424571501 0.256759674999629 0.819518275815512 0.565217391304348 15.2 15 2 abnormal lens development 0.0942914424571501 0.256759674999629 0.819518275815512 0.565217391304348 15.2 15 2 abnormal circulating hormone level 0.0354837207072418 0.132531164052949 0.81790186895986 0.564102564102564 15.2 15 2 increased circulating calcium level 0.0142167367509562 0.0654285525772497 0.817225917002042 0.563636363636364 15.2 15 2 abnormal lens morphology 0.000297226093946742 0.00292811845026741 0.81557828410486 0.5625 15.2 15 2 failure of primitive streak formation 0.0562806601882559 0.185673928671468 0.81557828410486 0.5625 15.2 15 2 increased circulating follicle stimulating hormone level 0.0562806601882559 0.185673928671468 0.81557828410486 0.5625 15.2 15 2 absent mandible 0.158185455092017 0.367720537239118 0.81557828410486 0.5625 15.2 15 2 abnormal bone marrow cell number 0.158185455092017 0.367720537239118 0.81557828410486 0.5625 15.2 15 2 abnormal pituitary gland morphology 0.158185455092017 0.367720537239118 0.81557828410486 0.5625 15.2 15 2 poor circulation 0.158185455092017 0.367720537239118 0.81557828410486 0.5625 15.2 15 2 abnormal intestinal absorption 0.158185455092017 0.367720537239118 0.81557828410486 0.5625 15.2 15 2 disorganized yolk sac vascular plexus 0.158185455092017 0.367720537239118 0.81557828410486 0.5625 15.2 15 2 impaired muscle relaxation 0.158185455092017 0.367720537239118 0.81557828410486 0.5625 15.2 15 2 abnormal molar crown morphology 0.158185455092017 0.367720537239118 0.81557828410486 0.5625 15.2 15 2 small epididymis 0.158185455092017 0.367720537239118 0.81557828410486 0.5625 15.2 15 2 abnormal amnion morphology 0.158185455092017 0.367720537239118 0.81557828410486 0.5625 15.2 15 2 sparse hair 0.00367340278399779 0.0238268303134146 0.813368044852544 0.560975609756098 15.2 15 2 abnormal tail morphology 0.00876942056880491 0.0466608206735876 0.812832229276224 0.560606060606061 15.2 15 2 abnormal liver physiology 0.00152438706528641 0.0118868740592475 0.811953491731061 0.56 15.2 15 2 ruffled hair 0.0908759692071086 0.254899008960164 0.811953491731061 0.56 15.2 15 2 mandible hypoplasia 0.0908759692071086 0.254899008960164 0.811953491731061 0.56 15.2 15 2 decreased placenta weight 0.0908759692071086 0.254899008960164 0.811953491731061 0.56 15.2 15 2 decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 0.0908759692071086 0.254899008960164 0.811953491731061 0.56 15.2 15 2 decreased T cell number 7.71689281055702e-05 0.000890755028596779 0.81051258047688 0.559006211180124 15.2 15 2 increased susceptibility to weight gain 0.0544561012166312 0.181952632888011 0.810247707084567 0.558823529411765 15.2 15 2 abnormal homeostasis 0.0334061869616243 0.12495923318352 0.809255971824978 0.558139534883721 15.2 15 2 decreased body temperature 0.0208045080213573 0.0889182219742257 0.808607529539861 0.557692307692308 15.2 15 2 impaired fertilization 0.00830588482568858 0.0446239492524846 0.80781087187529 0.557142857142857 15.2 15 2 thick epidermis 0.00830588482568858 0.0446239492524846 0.80781087187529 0.557142857142857 15.2 15 2 abnormal visceral yolk sac morphology 0.0053004410324505 0.0307339092499315 0.807548680745178 0.556962025316456 15.2 15 2 skin lesions 0.0127202419486415 0.0602123726874326 0.805509416399862 0.555555555555556 15.2 15 2 diluted coat color 0.020188211875181 0.088334524255959 0.805509416399862 0.555555555555556 15.2 15 2 abnormal uterus morphology 0.0526343339338406 0.178254466522026 0.805509416399862 0.555555555555556 15.2 15 2 abnormal megakaryocyte differentiation 0.150996795550754 0.367720537239118 0.805509416399862 0.555555555555556 15.2 15 2 abnormal thymus medulla morphology 0.150996795550754 0.367720537239118 0.805509416399862 0.555555555555556 15.2 15 2 acidosis 0.150996795550754 0.367720537239118 0.805509416399862 0.555555555555556 15.2 15 2 abnormal glycogen homeostasis 0.150996795550754 0.367720537239118 0.805509416399862 0.555555555555556 15.2 15 2 abnormal urinary bladder urothelium morphology 0.283864215903942 0.54253725475302 0.805509416399862 0.555555555555556 15.2 15 2 small nodose ganglion 0.283864215903942 0.54253725475302 0.805509416399862 0.555555555555556 15.2 15 2 dilated uterus 0.283864215903942 0.54253725475302 0.805509416399862 0.555555555555556 15.2 15 2 abnormal vagina epithelium morphology 0.283864215903942 0.54253725475302 0.805509416399862 0.555555555555556 15.2 15 2 psoriasis 0.283864215903942 0.54253725475302 0.805509416399862 0.555555555555556 15.2 15 2 multifocal hepatic necrosis 0.283864215903942 0.54253725475302 0.805509416399862 0.555555555555556 15.2 15 2 abnormal taste sensitivity 0.283864215903942 0.54253725475302 0.805509416399862 0.555555555555556 15.2 15 2 abnormal germ cell morphology 0.283864215903942 0.54253725475302 0.805509416399862 0.555555555555556 15.2 15 2 decreased circulating bicarbonate level 0.283864215903942 0.54253725475302 0.805509416399862 0.555555555555556 15.2 15 2 decreased muscle weight 0.283864215903942 0.54253725475302 0.805509416399862 0.555555555555556 15.2 15 2 abnormal oxygen consumption 0.283864215903942 0.54253725475302 0.805509416399862 0.555555555555556 15.2 15 2 absent adrenal gland 0.283864215903942 0.54253725475302 0.805509416399862 0.555555555555556 15.2 15 2 decreased susceptibility to atherosclerosis 0.283864215903942 0.54253725475302 0.805509416399862 0.555555555555556 15.2 15 2 decreased pulmonary ventilation 0.283864215903942 0.54253725475302 0.805509416399862 0.555555555555556 15.2 15 2 abnormal incisor color 0.283864215903942 0.54253725475302 0.805509416399862 0.555555555555556 15.2 15 2 abnormal telomere morphology 0.283864215903942 0.54253725475302 0.805509416399862 0.555555555555556 15.2 15 2 decreased susceptibility to parasitic infection induced morbidity/mortality 0.283864215903942 0.54253725475302 0.805509416399862 0.555555555555556 15.2 15 2 abnormal pulmonary alveolar system morphology 0.283864215903942 0.54253725475302 0.805509416399862 0.555555555555556 15.2 15 2 abnormal pulmonary alveolar parenchyma morphology 0.283864215903942 0.54253725475302 0.805509416399862 0.555555555555556 15.2 15 2 abnormal coronary sinus connection 0.283864215903942 0.54253725475302 0.805509416399862 0.555555555555556 15.2 15 2 increased bone mineralization 0.283864215903942 0.54253725475302 0.805509416399862 0.555555555555556 15.2 15 2 adipose tissue inflammation 0.283864215903942 0.54253725475302 0.805509416399862 0.555555555555556 15.2 15 2 maternal effect 0.0119818547307446 0.0572070319438143 0.800700404958669 0.552238805970149 15.2 15 2 dermatitis 0.0189705346630987 0.0831527840959611 0.79995417904538 0.551724137931034 15.2 15 2 abnormal enzyme/coenzyme level 0.0189705346630987 0.0831527840959611 0.79995417904538 0.551724137931034 15.2 15 2 abnormal respiratory system physiology 0.0303117677103273 0.114590459239269 0.79893382932721 0.551020408163265 15.2 15 2 decreased circulating phosphate level 0.0490497264428135 0.166227785458445 0.797454322235864 0.55 15.2 15 2 increased urine glucose level 0.144070405631216 0.357125195822271 0.797454322235864 0.55 15.2 15 2 abnormal trachea morphology 0.144070405631216 0.357125195822271 0.797454322235864 0.55 15.2 15 2 decreased myocardial infarction size 0.144070405631216 0.357125195822271 0.797454322235864 0.55 15.2 15 2 abnormal heart right ventricle morphology 0.144070405631216 0.357125195822271 0.797454322235864 0.55 15.2 15 2 kidney atrophy 0.144070405631216 0.357125195822271 0.797454322235864 0.55 15.2 15 2 decreased muscle cell glucose uptake 0.144070405631216 0.357125195822271 0.797454322235864 0.55 15.2 15 2 abnormal eye physiology 0.0183732648020094 0.0806769570962018 0.797454322235863 0.55 15.2 15 2 increased kidney weight 0.0293065265269689 0.111043388782689 0.796032835030452 0.549019607843137 15.2 15 2 hydronephrosis 0.00674799475991848 0.0380626688555492 0.794002139022721 0.547619047619048 15.2 15 2 spleen hyperplasia 0.0105676640016264 0.0531588760445816 0.792621265737464 0.546666666666667 15.2 15 2 abnormal trabecular bone morphology 0.00159875465219307 0.0122415948238266 0.79197144301499 0.546218487394958 15.2 15 2 abnormal skeleton physiology 0.077682181222174 0.220461409914612 0.790863790647137 0.545454545454545 15.2 15 2 abnormal amino acid level 0.0455981450295213 0.154741317545613 0.790863790647137 0.545454545454545 15.2 15 2 abnormal long bone epiphysis morphology 0.13743726510019 0.342046220046747 0.790863790647137 0.545454545454545 15.2 15 2 increased myocardial infarction size 0.13743726510019 0.342046220046747 0.790863790647137 0.545454545454545 15.2 15 2 decreased cardiac output 0.13743726510019 0.342046220046747 0.790863790647137 0.545454545454545 15.2 15 2 parakeratosis 0.13743726510019 0.342046220046747 0.790863790647137 0.545454545454545 15.2 15 2 abnormal female reproductive system physiology 0.13743726510019 0.342046220046747 0.790863790647137 0.545454545454545 15.2 15 2 abnormal basement membrane morphology 0.13743726510019 0.342046220046747 0.790863790647137 0.545454545454545 15.2 15 2 rough coat 0.13743726510019 0.342046220046747 0.790863790647137 0.545454545454545 15.2 15 2 abnormal ear position 0.264821550916468 0.510851964253364 0.790863790647137 0.545454545454545 15.2 15 2 absent semicircular canals 0.264821550916468 0.510851964253364 0.790863790647137 0.545454545454545 15.2 15 2 increased mast cell number 0.264821550916468 0.510851964253364 0.790863790647137 0.545454545454545 15.2 15 2 abnormal awl hair morphology 0.264821550916468 0.510851964253364 0.790863790647137 0.545454545454545 15.2 15 2 abnormal enteric ganglia morphology 0.264821550916468 0.510851964253364 0.790863790647137 0.545454545454545 15.2 15 2 abnormal glossopharyngeal ganglion morphology 0.264821550916468 0.510851964253364 0.790863790647137 0.545454545454545 15.2 15 2 impaired myelopoiesis 0.264821550916468 0.510851964253364 0.790863790647137 0.545454545454545 15.2 15 2 abnormal nerve fiber response 0.264821550916468 0.510851964253364 0.790863790647137 0.545454545454545 15.2 15 2 abnormal lymph circulation 0.264821550916468 0.510851964253364 0.790863790647137 0.545454545454545 15.2 15 2 dilated renal glomerular capsule 0.264821550916468 0.510851964253364 0.790863790647137 0.545454545454545 15.2 15 2 increased motor neuron number 0.264821550916468 0.510851964253364 0.790863790647137 0.545454545454545 15.2 15 2 increased circulating triiodothyronine level 0.264821550916468 0.510851964253364 0.790863790647137 0.545454545454545 15.2 15 2 abnormal superovulation 0.264821550916468 0.510851964253364 0.790863790647137 0.545454545454545 15.2 15 2 palatal shelf hypoplasia 0.264821550916468 0.510851964253364 0.790863790647137 0.545454545454545 15.2 15 2 shortened PR interval 0.264821550916468 0.510851964253364 0.790863790647137 0.545454545454545 15.2 15 2 increased pancreatic beta cell proliferation 0.264821550916468 0.510851964253364 0.790863790647137 0.545454545454545 15.2 15 2 thin hypoglossal nerve 0.264821550916468 0.510851964253364 0.790863790647137 0.545454545454545 15.2 15 2 decreased B cell proliferation 0.00990128864524453 0.0502687667754454 0.789195301637333 0.544303797468354 15.2 15 2 increased macrophage cell number 0.0264105012782437 0.10695084609214 0.788551323423023 0.543859649122807 15.2 15 2 abnormal dermal layer morphology 0.0745958505038216 0.211944235440613 0.787097772596437 0.542857142857143 15.2 15 2 impaired adaptive thermogenesis 0.0745958505038216 0.211944235440613 0.787097772596437 0.542857142857143 15.2 15 2 abnormal kidney physiology 0.0423174361577006 0.149629882647164 0.785371680989865 0.541666666666667 15.2 15 2 hemolytic anemia 0.131107777974548 0.327604819398984 0.785371680989865 0.541666666666667 15.2 15 2 small lymph nodes 0.131107777974548 0.327604819398984 0.785371680989865 0.541666666666667 15.2 15 2 decreased ovulation rate 0.131107777974548 0.327604819398984 0.785371680989865 0.541666666666667 15.2 15 2 abnormal tumor morphology 0.131107777974548 0.327604819398984 0.785371680989865 0.541666666666667 15.2 15 2 decreased fatty acid level 0.131107777974548 0.327604819398984 0.785371680989865 0.541666666666667 15.2 15 2 hypopigmentation 0.131107777974548 0.327604819398984 0.785371680989865 0.541666666666667 15.2 15 2 abnormal inner cell mass apoptosis 0.131107777974548 0.327604819398984 0.785371680989865 0.541666666666667 15.2 15 2 abnormal pancreatic beta cell physiology 0.0716114117831386 0.203930608827198 0.783738891632298 0.540540540540541 15.2 15 2 kidney inflammation 0.0407473035190179 0.146578333338477 0.782955152740666 0.54 15.2 15 2 decreased neutrophil cell number 0.00294987176040593 0.0200486502841797 0.780724511279866 0.538461538461538 15.2 15 2 increased vascular permeability 0.0687315222658882 0.195841536811451 0.780724511279866 0.538461538461538 15.2 15 2 abnormal ocular fundus morphology 0.125080938533193 0.313806187192453 0.780724511279866 0.538461538461538 15.2 15 2 decreased bone resorption 0.125080938533193 0.313806187192453 0.780724511279866 0.538461538461538 15.2 15 2 decreased Peyer's patch number 0.125080938533193 0.313806187192453 0.780724511279866 0.538461538461538 15.2 15 2 absent myocardial trabeculae 0.247953339434697 0.482427791821517 0.780724511279866 0.538461538461538 15.2 15 2 abnormal renal/urinary system morphology 0.247953339434697 0.482427791821517 0.780724511279866 0.538461538461538 15.2 15 2 uterus hypoplasia 0.247953339434697 0.482427791821517 0.780724511279866 0.538461538461538 15.2 15 2 increased pituitary adenoma incidence 0.247953339434697 0.482427791821517 0.780724511279866 0.538461538461538 15.2 15 2 anal atresia 0.247953339434697 0.482427791821517 0.780724511279866 0.538461538461538 15.2 15 2 small otic vesicle 0.247953339434697 0.482427791821517 0.780724511279866 0.538461538461538 15.2 15 2 decreased follicle stimulating hormone level 0.247953339434697 0.482427791821517 0.780724511279866 0.538461538461538 15.2 15 2 increased circulating ammonia level 0.247953339434697 0.482427791821517 0.780724511279866 0.538461538461538 15.2 15 2 increased prostaglandin level 0.247953339434697 0.482427791821517 0.780724511279866 0.538461538461538 15.2 15 2 decreased cardiac stroke volume 0.247953339434697 0.482427791821517 0.780724511279866 0.538461538461538 15.2 15 2 increased leukocyte cell number 0.00106061414395345 0.00872157911763378 0.779955324569246 0.537931034482759 15.2 15 2 abnormal femur morphology 0.0220597910465265 0.0931642278917396 0.779059853473299 0.537313432835821 15.2 15 2 thick ventricular wall 0.0659569771278022 0.193859851904012 0.778004216815476 0.536585365853659 15.2 15 2 abnormal cholesterol homeostasis 0.0659569771278022 0.193859851904012 0.778004216815476 0.536585365853659 15.2 15 2 liver inflammation 0.00370248004375405 0.0239841643459328 0.773289039743868 0.533333333333333 15.2 15 2 abnormal long bone epiphyseal plate morphology 0.0336247517030064 0.125682298814768 0.773289039743868 0.533333333333333 15.2 15 2 abnormal hair cycle 0.113902438969097 0.286338875124435 0.773289039743868 0.533333333333333 15.2 15 2 increased metastatic potential 0.113902438969097 0.286338875124435 0.773289039743868 0.533333333333333 15.2 15 2 arrested T cell differentiation 0.113902438969097 0.286338875124435 0.773289039743868 0.533333333333333 15.2 15 2 abnormal fat pad morphology 0.113902438969097 0.286338875124435 0.773289039743868 0.533333333333333 15.2 15 2 absent incisors 0.232817293461422 0.455114355587652 0.773289039743868 0.533333333333333 15.2 15 2 abnormal apical ectodermal ridge morphology 0.232817293461422 0.455114355587652 0.773289039743868 0.533333333333333 15.2 15 2 placental labyrinth hypoplasia 0.232817293461422 0.455114355587652 0.773289039743868 0.533333333333333 15.2 15 2 increased airway responsiveness 0.232817293461422 0.455114355587652 0.773289039743868 0.533333333333333 15.2 15 2 abnormal bronchus morphology 0.232817293461422 0.455114355587652 0.773289039743868 0.533333333333333 15.2 15 2 abnormal dendritic cell morphology 0.232817293461422 0.455114355587652 0.773289039743868 0.533333333333333 15.2 15 2 lactation failure 0.232817293461422 0.455114355587652 0.773289039743868 0.533333333333333 15.2 15 2 decreased brown adipose tissue mass 0.232817293461422 0.455114355587652 0.773289039743868 0.533333333333333 15.2 15 2 increased heart weight 0.00203080926133361 0.0147309976654845 0.771898232118429 0.532374100719424 15.2 15 2 abnormal T-helper 1 physiology 0.0582556515516435 0.191554439173448 0.771232419957315 0.531914893617021 15.2 15 2 polydipsia 0.108727540223075 0.276298884214047 0.770268379432368 0.53125 15.2 15 2 abnormal epidermis stratum corneum morphology 0.0558890613590794 0.184626879323652 0.769343687500276 0.530612244897959 15.2 15 2 abnormal skin morphology 0.0299188485067295 0.113277223227534 0.76889535201805 0.53030303030303 15.2 15 2 abnormal lipid level 0.0163875199389102 0.0743867807445971 0.768630672034567 0.530120481927711 15.2 15 2 abnormal oocyte morphology 0.10381152122841 0.274855835774071 0.767603090922221 0.529411764705882 15.2 15 2 increased width of hypertrophic chondrocyte zone 0.10381152122841 0.274855835774071 0.767603090922221 0.529411764705882 15.2 15 2 distended urinary bladder 0.219105002761841 0.429998969917222 0.767603090922221 0.529411764705882 15.2 15 2 decreased vasoconstriction 0.219105002761841 0.429998969917222 0.767603090922221 0.529411764705882 15.2 15 2 abnormal melanosome morphology 0.219105002761841 0.429998969917222 0.767603090922221 0.529411764705882 15.2 15 2 increased hepatoma incidence 0.219105002761841 0.429998969917222 0.767603090922221 0.529411764705882 15.2 15 2 abnormal blood homeostasis 0.0070399329320677 0.0384875454253152 0.763114183957764 0.526315789473684 15.2 15 2 abnormal circulating amino acid level 0.0473483417539021 0.160571233964324 0.763114183957764 0.526315789473684 15.2 15 2 increased inflammatory response 0.0130659776474813 0.0617901509469766 0.763114183957764 0.526315789473684 15.2 15 2 abnormal retinal outer nuclear layer morphology 0.0947031361108971 0.257739662008596 0.763114183957764 0.526315789473684 15.2 15 2 enlarged adrenal glands 0.206590576674273 0.406722643037004 0.763114183957764 0.526315789473684 15.2 15 2 delayed sexual maturation 0.206590576674273 0.406722643037004 0.763114183957764 0.526315789473684 15.2 15 2 absent amnion 0.206590576674273 0.406722643037004 0.763114183957764 0.526315789473684 15.2 15 2 decreased fertilization frequency 0.206590576674273 0.406722643037004 0.763114183957764 0.526315789473684 15.2 15 2 increased liver cholesterol level 0.206590576674273 0.406722643037004 0.763114183957764 0.526315789473684 15.2 15 2 decreased susceptibility to weight gain 0.206590576674273 0.406722643037004 0.763114183957764 0.526315789473684 15.2 15 2 decreased IgM level 0.0125799230700856 0.0600049063026615 0.762327468304199 0.525773195876289 15.2 15 2 abnormal colon morphology 0.0454285371065227 0.154270970720103 0.761820770086649 0.525423728813559 15.2 15 2 abnormal female reproductive system morphology 0.0904850860703391 0.254899008960164 0.76120639849787 0.525 15.2 15 2 impaired ovarian folliculogenesis 0.0904850860703391 0.254899008960164 0.76120639849787 0.525 15.2 15 2 increased double-negative T cell number 0.0435884054540135 0.152389645186647 0.76061217023987 0.524590163934426 15.2 15 2 abnormal vibrissa morphology 0.0864748636842176 0.244577854934044 0.759480306891298 0.523809523809524 15.2 15 2 abnormal hematopoietic system physiology 0.195102237080177 0.385324981926907 0.759480306891298 0.523809523809524 15.2 15 2 hypoalgesia 0.195102237080177 0.385324981926907 0.759480306891298 0.523809523809524 15.2 15 2 complete atrioventricular septal defect 0.195102237080177 0.385324981926907 0.759480306891298 0.523809523809524 15.2 15 2 increased bone ossification 0.195102237080177 0.385324981926907 0.759480306891298 0.523809523809524 15.2 15 2 abnormal myelopoiesis 0.0826610188810135 0.234190529005149 0.757911132703507 0.522727272727273 15.2 15 2 blistering 0.184505435256234 0.377331143963212 0.756478408445088 0.521739130434783 15.2 15 2 hypotension 0.184505435256234 0.377331143963212 0.756478408445088 0.521739130434783 15.2 15 2 increased lymphocyte cell number 0.0369623007314412 0.136313896322402 0.756478408445088 0.521739130434783 15.2 15 2 decreased T cell proliferation 0.00373823482541353 0.024184289020068 0.754348683196087 0.52027027027027 15.2 15 2 abnormal circulating protein level 0.0722926323524791 0.205635132048933 0.753956813750271 0.52 15.2 15 2 decreased oocyte number 0.0722926323524791 0.205635132048933 0.753956813750271 0.52 15.2 15 2 abnormal feces composition 0.174692237472608 0.377331143963212 0.753956813750271 0.52 15.2 15 2 abnormal response to infection 0.0301167986855555 0.113939979817976 0.752488543421643 0.518987341772152 15.2 15 2 rectal prolapse 0.165574342835976 0.367720537239118 0.751808788639871 0.518518518518518 15.2 15 2 thick interventricular septum 0.165574342835976 0.367720537239118 0.751808788639871 0.518518518518518 15.2 15 2 decreased retinal photoreceptor cell number 0.157078316115603 0.367720537239118 0.749957042855044 0.517241379310345 15.2 15 2 abnormal CD8-positive, alpha-beta T cell physiology 0.157078316115603 0.367720537239118 0.749957042855044 0.517241379310345 15.2 15 2 abnormal intestine physiology 0.149142229651251 0.367720537239118 0.748344232010194 0.516129032258065 15.2 15 2 abnormal T cell differentiation 0.0192936213181111 0.0844945123746505 0.746491894802248 0.514851485148515 15.2 15 2 increased B cell number 0.0140147079268442 0.0650560409822891 0.743547153599873 0.512820512820513 15.2 15 2 increased liver weight 0.0320337892671157 0.121008429463858 0.741434803731691 0.511363636363636 15.2 15 2 altered response to myocardial infarction 0.105598470519426 0.276298884214047 0.741068663087873 0.511111111111111 15.2 15 2 hepatic necrosis 0.100713159588077 0.272982555915461 0.740383123159022 0.51063829787234 15.2 15 2 increased spleen weight 0.0240408964553113 0.0991712777646088 0.731374036483415 0.504424778761062 15.2 15 2 increased eosinophil cell number 0.0903899124503943 0.254899008960164 0.724958474759876 0.5 15.2 15 2 delayed wound healing 0.1321642110864 0.330078790238373 0.724958474759876 0.5 15.2 15 2 abnormal spleen red pulp morphology 0.179614947094657 0.377331143963212 0.724958474759876 0.5 15.2 15 2 decreased pancreatic beta cell number 0.179614947094657 0.377331143963212 0.724958474759876 0.5 15.2 15 2 abnormal skin physiology 0.179614947094657 0.377331143963212 0.724958474759876 0.5 15.2 15 2 brain inflammation 0.26911074771733 0.518723738819728 0.724958474759876 0.5 15.2 15 2 abnormal physiological neovascularization 0.26911074771733 0.518723738819728 0.724958474759876 0.5 15.2 15 2 abnormal lateral semicircular canal morphology 0.387526004087763 0.572668099616588 0.724958474759876 0.5 15.2 15 2 abnormal otic capsule morphology 0.387526004087763 0.572668099616588 0.724958474759876 0.5 15.2 15 2 abnormal auchene hair morphology 0.387526004087763 0.572668099616588 0.724958474759876 0.5 15.2 15 2 absent maxillary shelf 0.387526004087763 0.572668099616588 0.724958474759876 0.5 15.2 15 2 absent palatine bone horizontal plate 0.387526004087763 0.572668099616588 0.724958474759876 0.5 15.2 15 2 enlarged testis 0.387526004087763 0.572668099616588 0.724958474759876 0.5 15.2 15 2 abnormal epidermis suprabasal layer morphology 0.387526004087763 0.572668099616588 0.724958474759876 0.5 15.2 15 2 abnormal gland morphology 0.387526004087763 0.572668099616588 0.724958474759876 0.5 15.2 15 2 primary sex reversal 0.387526004087763 0.572668099616588 0.724958474759876 0.5 15.2 15 2 abnormal bone healing 0.387526004087763 0.572668099616588 0.724958474759876 0.5 15.2 15 2 impaired basement membrane formation 0.387526004087763 0.572668099616588 0.724958474759876 0.5 15.2 15 2 abnormal scala media morphology 0.387526004087763 0.572668099616588 0.724958474759876 0.5 15.2 15 2 absent CD4-positive, alpha beta T cells 0.387526004087763 0.572668099616588 0.724958474759876 0.5 15.2 15 2 increased defecation amount 0.387526004087763 0.572668099616588 0.724958474759876 0.5 15.2 15 2 abnormal reproductive system development 0.387526004087763 0.572668099616588 0.724958474759876 0.5 15.2 15 2 decreased prolactin level 0.387526004087763 0.572668099616588 0.724958474759876 0.5 15.2 15 2 abnormal corneal endothelium morphology 0.387526004087763 0.572668099616588 0.724958474759876 0.5 15.2 15 2 ascites 0.387526004087763 0.572668099616588 0.724958474759876 0.5 15.2 15 2 increased susceptibility to atherosclerosis 0.387526004087763 0.572668099616588 0.724958474759876 0.5 15.2 15 2 increased kidney iron level 0.387526004087763 0.572668099616588 0.724958474759876 0.5 15.2 15 2 common ventricle 0.387526004087763 0.572668099616588 0.724958474759876 0.5 15.2 15 2 thick aortic valve 0.387526004087763 0.572668099616588 0.724958474759876 0.5 15.2 15 2 abnormal response/metabolism to endogenous compounds 0.0577833029634007 0.190378763074781 0.724958474759876 0.5 15.2 15 2 dehydration 0.0753610078546288 0.213996012600901 0.724958474759876 0.5 15.2 15 2 decreased eosinophil cell number 0.0863366160220437 0.244325747843952 0.724958474759876 0.5 15.2 15 2 increased susceptibility to injury 0.114265913002405 0.287107533932811 0.724958474759876 0.5 15.2 15 2 abnormal compact bone morphology 0.161697191403133 0.367720537239118 0.724958474759876 0.5 15.2 15 2 impaired wound healing 0.170350446732735 0.375828590907032 0.724958474759876 0.5 15.2 15 2 increased circulating luteinizing hormone level 0.211799274090192 0.416647445076593 0.724958474759876 0.5 15.2 15 2 abnormal retinal inner nuclear layer morphology 0.211799274090192 0.416647445076593 0.724958474759876 0.5 15.2 15 2 small seminal vesicle 0.224303536412024 0.440027639451821 0.724958474759876 0.5 15.2 15 2 abnormal retinal layer morphology 0.252767209060163 0.491025718498365 0.724958474759876 0.5 15.2 15 2 abnormal blood-brain barrier function 0.252767209060163 0.491025718498365 0.724958474759876 0.5 15.2 15 2 impaired humoral immune response 0.252767209060163 0.491025718498365 0.724958474759876 0.5 15.2 15 2 abnormal retinal rod cell morphology 0.287213209972927 0.547675630362327 0.724958474759876 0.5 15.2 15 2 thick dermal layer 0.287213209972927 0.547675630362327 0.724958474759876 0.5 15.2 15 2 abnormal Peyer's patch follicle morphology 0.287213209972927 0.547675630362327 0.724958474759876 0.5 15.2 15 2 abnormal white adipose tissue morphology 0.287213209972927 0.547675630362327 0.724958474759876 0.5 15.2 15 2 increased circulating renin level 0.287213209972927 0.547675630362327 0.724958474759876 0.5 15.2 15 2 decreased heart rate variability 0.287213209972927 0.547675630362327 0.724958474759876 0.5 15.2 15 2 abnormal vasoconstriction 0.330339104916841 0.572668099616588 0.724958474759876 0.5 15.2 15 2 decreased mast cell number 0.307449131830826 0.572668099616588 0.724958474759876 0.5 15.2 15 2 mixed cellular infiltration to dermis 0.307449131830826 0.572668099616588 0.724958474759876 0.5 15.2 15 2 extended life span 0.330339104916841 0.572668099616588 0.724958474759876 0.5 15.2 15 2 abnormal extraembryonic endoderm formation 0.307449131830826 0.572668099616588 0.724958474759876 0.5 15.2 15 2 abnormal fluid regulation 0.330339104916841 0.572668099616588 0.724958474759876 0.5 15.2 15 2 abnormal meiosis 0.307449131830826 0.572668099616588 0.724958474759876 0.5 15.2 15 2 white spotting 0.307449131830826 0.572668099616588 0.724958474759876 0.5 15.2 15 2 large intestinal inflammation 0.307449131830826 0.572668099616588 0.724958474759876 0.5 15.2 15 2 abnormal vascular endothelial cell migration 0.330339104916841 0.572668099616588 0.724958474759876 0.5 15.2 15 2 vascular smooth muscle hypoplasia 0.330339104916841 0.572668099616588 0.724958474759876 0.5 15.2 15 2 split sternum 0.330339104916841 0.572668099616588 0.724958474759876 0.5 15.2 15 2 abnormal epididymis epithelium morphology 0.307449131830826 0.572668099616588 0.724958474759876 0.5 15.2 15 2 increased circulating estradiol level 0.307449131830826 0.572668099616588 0.724958474759876 0.5 15.2 15 2 abnormal Langerhans cell physiology 0.307449131830826 0.572668099616588 0.724958474759876 0.5 15.2 15 2 decreased creatinine clearance 0.307449131830826 0.572668099616588 0.724958474759876 0.5 15.2 15 2 abnormal intestinal epithelium morphology 0.12584652045718 0.315567761731084 0.724958474759876 0.5 15.2 15 2 decreased metastatic potential 0.237903092537919 0.464873482080183 0.724958474759876 0.5 15.2 15 2 decreased digestive secretion 0.356640939001508 0.572668099616588 0.724958474759876 0.5 15.2 15 2 amyloidosis 0.356640939001508 0.572668099616588 0.724958474759876 0.5 15.2 15 2 abnormal enteric nervous system morphology 0.356640939001508 0.572668099616588 0.724958474759876 0.5 15.2 15 2 abnormal tracheal ciliated epithelium morphology 0.356640939001508 0.572668099616588 0.724958474759876 0.5 15.2 15 2 increased urine phosphate level 0.356640939001508 0.572668099616588 0.724958474759876 0.5 15.2 15 2 increased circulating parathyroid hormone level 0.356640939001508 0.572668099616588 0.724958474759876 0.5 15.2 15 2 abnormal aorta elastic fiber morphology 0.356640939001508 0.572668099616588 0.724958474759876 0.5 15.2 15 2 absent tail 0.356640939001508 0.572668099616588 0.724958474759876 0.5 15.2 15 2 increased fear-related response 0.356640939001508 0.572668099616588 0.724958474759876 0.5 15.2 15 2 hematuria 0.356640939001508 0.572668099616588 0.724958474759876 0.5 15.2 15 2 abnormal anogenital distance 0.356640939001508 0.572668099616588 0.724958474759876 0.5 15.2 15 2 decreased renal glomerular filtration rate 0.356640939001508 0.572668099616588 0.724958474759876 0.5 15.2 15 2 decreased keratinocyte proliferation 0.356640939001508 0.572668099616588 0.724958474759876 0.5 15.2 15 2 impaired behavioral response to cocaine 0.356640939001508 0.572668099616588 0.724958474759876 0.5 15.2 15 2 abnormal colon goblet cell morphology 0.356640939001508 0.572668099616588 0.724958474759876 0.5 15.2 15 2 polyuria 0.0801895516603528 0.227447559583954 0.715543429633124 0.493506493506494 15.2 15 2 abnormal epidermal layer morphology 0.0960795753445522 0.261342748681874 0.714451830198138 0.492753623188406 15.2 15 2 abnormal coat/ hair morphology 0.139976790941349 0.348018258337438 0.711280012971954 0.490566037735849 15.2 15 2 cardiac hypertrophy 0.0621804667375151 0.193859851904012 0.710163403846409 0.489795918367347 15.2 15 2 abnormal urine homeostasis 0.0649189241498523 0.193859851904012 0.709855173202378 0.489583333333333 15.2 15 2 abnormal lens fiber morphology 0.199369930085747 0.393597381816108 0.706369795919879 0.487179487179487 15.2 15 2 abnormal retinal photoreceptor layer morphology 0.248171659147288 0.482663801508114 0.701572717509557 0.483870967741935 15.2 15 2 increased neutrophil cell number 0.0410892709017355 0.147525812605996 0.699959906664708 0.482758620689655 15.2 15 2 decreased bone strength 0.262872168199809 0.510456298514461 0.699959906664708 0.482758620689655 15.2 15 2 abnormal CD4-positive, alpha-beta T cell physiology 0.137562130472225 0.34218579954966 0.694326426530585 0.47887323943662 15.2 15 2 abnormal lymphocyte physiology 0.206023375104438 0.406571317391742 0.693438541074664 0.478260869565217 15.2 15 2 abnormal postnatal growth 0.315340501713765 0.572668099616588 0.693438541074664 0.478260869565217 15.2 15 2 pancreas inflammation 0.315340501713765 0.572668099616588 0.693438541074664 0.478260869565217 15.2 15 2 decreased IgG level 0.0827469468222967 0.234300546636839 0.69230268760853 0.477477477477477 15.2 15 2 hypertension 0.216863274324097 0.426272141352186 0.692005816816245 0.477272727272727 15.2 15 2 decreased sensitivity to induced morbidity/mortality 0.216863274324097 0.426272141352186 0.692005816816245 0.477272727272727 15.2 15 2 abnormal tumor vascularization 0.336391211932925 0.572668099616588 0.690436642628453 0.476190476190476 15.2 15 2 abnormal male meiosis 0.17364981164508 0.377331143963212 0.689304779279882 0.475409836065574 15.2 15 2 abnormal cytokine secretion 0.0572687497341303 0.188808502271238 0.687298294252869 0.474025974025974 15.2 15 2 decreased susceptibility to induced arthritis 0.191066367818353 0.377954345883224 0.686802765561988 0.473684210526316 15.2 15 2 shiny skin 0.359773579941715 0.572668099616588 0.686802765561988 0.473684210526316 15.2 15 2 thin dermal layer 0.359773579941715 0.572668099616588 0.686802765561988 0.473684210526316 15.2 15 2 decreased germ cell number 0.359773579941715 0.572668099616588 0.686802765561988 0.473684210526316 15.2 15 2 abnormal neural crest cell migration 0.359773579941715 0.572668099616588 0.686802765561988 0.473684210526316 15.2 15 2 increased circulating VLDL cholesterol level 0.359773579941715 0.572668099616588 0.686802765561988 0.473684210526316 15.2 15 2 decreased liver regeneration 0.359773579941715 0.572668099616588 0.686802765561988 0.473684210526316 15.2 15 2 decreased circulating magnesium level 0.359773579941715 0.572668099616588 0.686802765561988 0.473684210526316 15.2 15 2 lung inflammation 0.08191686028049 0.232214461478882 0.68231385859753 0.470588235294118 15.2 15 2 aminoaciduria 0.385977246558813 0.572668099616588 0.68231385859753 0.470588235294118 15.2 15 2 abnormal tendon morphology 0.385977246558813 0.572668099616588 0.68231385859753 0.470588235294118 15.2 15 2 delayed heart development 0.385977246558813 0.572668099616588 0.68231385859753 0.470588235294118 15.2 15 2 abnormal cell cytoskeleton morphology 0.385977246558813 0.572668099616588 0.68231385859753 0.470588235294118 15.2 15 2 abnormal crypts of Lieberkuhn morphology 0.299890547442458 0.571630449626908 0.679648570087384 0.46875 15.2 15 2 salivary gland inflammation 0.317662896270296 0.572668099616588 0.676627909775884 0.466666666666667 15.2 15 2 abnormal spleen marginal zone morphology 0.317662896270296 0.572668099616588 0.676627909775884 0.466666666666667 15.2 15 2 abnormal fontanelle morphology 0.415670689940333 0.582196419609559 0.676627909775884 0.466666666666667 15.2 15 2 vagina atresia 0.415670689940333 0.582196419609559 0.676627909775884 0.466666666666667 15.2 15 2 liver vascular congestion 0.415670689940333 0.582196419609559 0.676627909775884 0.466666666666667 15.2 15 2 abnormal coronary vessel morphology 0.415670689940333 0.582196419609559 0.676627909775884 0.466666666666667 15.2 15 2 reddish skin 0.336937832622761 0.572668099616588 0.673175726562742 0.464285714285714 15.2 15 2 decreased circulating progesterone level 0.336937832622761 0.572668099616588 0.673175726562742 0.464285714285714 15.2 15 2 decreased inflammatory response 0.174321759103118 0.377331143963212 0.673175726562742 0.464285714285714 15.2 15 2 abnormal leukocyte cell number 0.357921320757789 0.572668099616588 0.669192438239885 0.461538461538462 15.2 15 2 abnormal kidney cortex morphology 0.357921320757789 0.572668099616588 0.669192438239885 0.461538461538462 15.2 15 2 increased autoantibody level 0.300842276571327 0.572668099616588 0.669192438239885 0.461538461538462 15.2 15 2 pulmonary edema 0.357921320757789 0.572668099616588 0.669192438239885 0.461538461538462 15.2 15 2 abnormal mast cell morphology 0.449801738630202 0.619535894154279 0.669192438239885 0.461538461538462 15.2 15 2 short hair 0.449801738630202 0.619535894154279 0.669192438239885 0.461538461538462 15.2 15 2 increased circulating adrenocorticotropin level 0.449801738630202 0.619535894154279 0.669192438239885 0.461538461538462 15.2 15 2 abnormal pulmonary alveolus epithelial cell morphology 0.449801738630202 0.619535894154279 0.669192438239885 0.461538461538462 15.2 15 2 abnormal intercostal muscle morphology 0.449801738630202 0.619535894154279 0.669192438239885 0.461538461538462 15.2 15 2 abnormal soleus morphology 0.449801738630202 0.619535894154279 0.669192438239885 0.461538461538462 15.2 15 2 absent lateral semicircular canal 0.449801738630202 0.619535894154279 0.669192438239885 0.461538461538462 15.2 15 2 abnormal vestibulocochlear ganglion morphology 0.449801738630202 0.619535894154279 0.669192438239885 0.461538461538462 15.2 15 2 increased renin activity 0.449801738630202 0.619535894154279 0.669192438239885 0.461538461538462 15.2 15 2 decreased circulating chloride level 0.317423510485618 0.572668099616588 0.666178057887453 0.459459459459459 15.2 15 2 abnormal NK cell physiology 0.247596526504088 0.482427791821517 0.665535648959886 0.459016393442623 15.2 15 2 curly vibrissae 0.380864463324097 0.572668099616588 0.664545268529886 0.458333333333333 15.2 15 2 increased circulating total protein level 0.380864463324097 0.572668099616588 0.664545268529886 0.458333333333333 15.2 15 2 abnormal dendritic cell physiology 0.170775083584991 0.376598422356086 0.663980659125868 0.457943925233645 15.2 15 2 abnormal intestinal goblet cell morphology 0.335203997103376 0.572668099616588 0.662819176923315 0.457142857142857 15.2 15 2 increased sensitivity to induced morbidity/mortality 0.103766925424578 0.274855835774071 0.661918607389452 0.456521739130435 15.2 15 2 increased activated T cell number 0.406077880993561 0.572668099616588 0.659053158872614 0.454545454545455 15.2 15 2 renal interstitial fibrosis 0.315838268978218 0.572668099616588 0.659053158872614 0.454545454545455 15.2 15 2 abnormal circulating lipid level 0.406077880993561 0.572668099616588 0.659053158872614 0.454545454545455 15.2 15 2 diarrhea 0.354310778985851 0.572668099616588 0.659053158872614 0.454545454545455 15.2 15 2 pulmonary vascular congestion 0.406077880993561 0.572668099616588 0.659053158872614 0.454545454545455 15.2 15 2 abnormal stomach epithelium morphology 0.489779715063843 0.664662870278946 0.659053158872614 0.454545454545455 15.2 15 2 abnormal large intestine morphology 0.489779715063843 0.664662870278946 0.659053158872614 0.454545454545455 15.2 15 2 vasculitis 0.489779715063843 0.664662870278946 0.659053158872614 0.454545454545455 15.2 15 2 abnormal primary sex determination 0.489779715063843 0.664662870278946 0.659053158872614 0.454545454545455 15.2 15 2 variable body spotting 0.489779715063843 0.664662870278946 0.659053158872614 0.454545454545455 15.2 15 2 patent ductus arteriosus 0.489779715063843 0.664662870278946 0.659053158872614 0.454545454545455 15.2 15 2 allodynia 0.489779715063843 0.664662870278946 0.659053158872614 0.454545454545455 15.2 15 2 pathological neovascularization 0.489779715063843 0.664662870278946 0.659053158872614 0.454545454545455 15.2 15 2 increased number of Howell-Jolly bodies 0.489779715063843 0.664662870278946 0.659053158872614 0.454545454545455 15.2 15 2 increased subcutaneous adipose tissue amount 0.489779715063843 0.664662870278946 0.659053158872614 0.454545454545455 15.2 15 2 decreased core body temperature 0.489779715063843 0.664662870278946 0.659053158872614 0.454545454545455 15.2 15 2 chylous ascites 0.489779715063843 0.664662870278946 0.659053158872614 0.454545454545455 15.2 15 2 hypolactation 0.489779715063843 0.664662870278946 0.659053158872614 0.454545454545455 15.2 15 2 abnormal CD8-positive, alpha beta T cell morphology 0.374890973901009 0.572668099616588 0.65480120300892 0.451612903225806 15.2 15 2 increased susceptibility to weight loss 0.349982186775716 0.572668099616588 0.652462627283888 0.45 15.2 15 2 abnormal induced retinal neovascularization 0.433952260852575 0.599531379545005 0.652462627283888 0.45 15.2 15 2 increased T cell proliferation 0.22485062617306 0.440927026098138 0.650430033429421 0.448598130841121 15.2 15 2 abnormal circulating glucose level 0.39711618496641 0.572668099616588 0.649962770474371 0.448275862068966 15.2 15 2 increased double-positive T cell number 0.39711618496641 0.572668099616588 0.649962770474371 0.448275862068966 15.2 15 2 wrinkled skin 0.421188147292195 0.587594749395588 0.64440753311989 0.444444444444444 15.2 15 2 increased susceptibility to autoimmune disorder 0.464988475827522 0.639921899651984 0.64440753311989 0.444444444444444 15.2 15 2 abnormal sperm axoneme morphology 0.464988475827522 0.639921899651984 0.64440753311989 0.444444444444444 15.2 15 2 abnormal retinal photoreceptor morphology 0.410253761844915 0.575257177333273 0.639669242435185 0.441176470588235 15.2 15 2 decreased regulatory T cell number 0.410253761844915 0.575257177333273 0.639669242435185 0.441176470588235 15.2 15 2 increased pre-B cell number 0.44734601911422 0.617692602024215 0.637963457788691 0.44 15.2 15 2 sepsis 0.499843012914394 0.677764783115048 0.634338665414891 0.4375 15.2 15 2 abnormal urinary bladder physiology 0.499843012914394 0.677764783115048 0.634338665414891 0.4375 15.2 15 2 acanthosis 0.421240386280345 0.587594749395588 0.632015080559892 0.435897435897436 15.2 15 2 abnormal hepatocyte physiology 0.475875865054941 0.648270106420683 0.63039867370424 0.434782608695652 15.2 15 2 gastrointestinal hemorrhage 0.457874582204615 0.630480499991132 0.628297344791892 0.433333333333333 15.2 15 2 abnormal T cell activation 0.377196016211788 0.572668099616588 0.626991113305839 0.432432432432432 15.2 15 2 skin inflammation 0.443199746494137 0.61213735114057 0.626991113305839 0.432432432432432 15.2 15 2 decreased macrophage cell number 0.430663005327601 0.595317713671802 0.626100500928984 0.431818181818182 15.2 15 2 abnormal stria vascularis morphology 0.48437588329427 0.659668770705993 0.621392978365608 0.428571428571429 15.2 15 2 increased incidence of induced tumors 0.507123047542313 0.687197859040914 0.621392978365608 0.428571428571429 15.2 15 2 dry skin 0.507123047542313 0.687197859040914 0.621392978365608 0.428571428571429 15.2 15 2 absent atrioventricular cushions 0.539398713915224 0.705073200664277 0.621392978365608 0.428571428571429 15.2 15 2 abnormal zigzag hair morphology 0.539398713915224 0.705073200664277 0.621392978365608 0.428571428571429 15.2 15 2 abnormal antigen presentation 0.539398713915224 0.705073200664277 0.621392978365608 0.428571428571429 15.2 15 2 abnormal spleen periarteriolar lymphoid sheath morphology 0.539398713915224 0.705073200664277 0.621392978365608 0.428571428571429 15.2 15 2 abnormal positive T cell selection 0.539398713915224 0.705073200664277 0.621392978365608 0.428571428571429 15.2 15 2 abnormal iris pigmentation 0.539398713915224 0.705073200664277 0.621392978365608 0.428571428571429 15.2 15 2 abnormal respiratory motile cilium physiology 0.539398713915224 0.705073200664277 0.621392978365608 0.428571428571429 15.2 15 2 decreased susceptibility to injury 0.424326378170514 0.587594749395588 0.618346934354012 0.426470588235294 15.2 15 2 flaky skin 0.541508400108109 0.706902201663039 0.610491347166211 0.421052631578947 15.2 15 2 abnormal photoreceptor inner segment morphology 0.541508400108109 0.706902201663039 0.610491347166211 0.421052631578947 15.2 15 2 eyelids fail to open 0.541508400108109 0.706902201663039 0.610491347166211 0.421052631578947 15.2 15 2 decreased liver glycogen level 0.541508400108109 0.706902201663039 0.610491347166211 0.421052631578947 15.2 15 2 thin interventricular septum 0.541508400108109 0.706902201663039 0.610491347166211 0.421052631578947 15.2 15 2 abnormal immune system physiology 0.433483421480966 0.59905000607439 0.608029688508283 0.419354838709677 15.2 15 2 decreased susceptibility to bacterial infection induced morbidity/mortality 0.517807188201665 0.70135876975314 0.608029688508283 0.419354838709677 15.2 15 2 abnormal T-helper 2 physiology 0.491135222548442 0.666320625082765 0.606328906162805 0.418181818181818 15.2 15 2 abnormal hair shaft morphology 0.50721417857251 0.687197859040914 0.604132062299896 0.416666666666667 15.2 15 2 abnormal cardiac muscle contractility 0.543741152005544 0.709630700741758 0.604132062299896 0.416666666666667 15.2 15 2 abnormal rectum morphology 0.584878840822654 0.759930068710552 0.604132062299896 0.416666666666667 15.2 15 2 ear inflammation 0.584878840822654 0.759930068710552 0.604132062299896 0.416666666666667 15.2 15 2 small intestinal inflammation 0.584878840822654 0.759930068710552 0.604132062299896 0.416666666666667 15.2 15 2 impaired sperm capacitation 0.584878840822654 0.759930068710552 0.604132062299896 0.416666666666667 15.2 15 2 increased placenta weight 0.584878840822654 0.759930068710552 0.604132062299896 0.416666666666667 15.2 15 2 hemoperitoneum 0.584878840822654 0.759930068710552 0.604132062299896 0.416666666666667 15.2 15 2 decreased oligodendrocyte number 0.584878840822654 0.759930068710552 0.604132062299896 0.416666666666667 15.2 15 2 decreased prostaglandin level 0.584878840822654 0.759930068710552 0.604132062299896 0.416666666666667 15.2 15 2 increased tumor growth/size 0.5258625365006 0.705073200664277 0.601185076630141 0.414634146341463 15.2 15 2 decreased granulocyte number 0.545970964466877 0.712353933444194 0.599965634284035 0.413793103448276 15.2 15 2 abnormal immune system morphology 0.529313047872867 0.705073200664277 0.598878740019028 0.41304347826087 15.2 15 2 abnormal thrombosis 0.532487770688728 0.705073200664277 0.597024626272839 0.411764705882353 15.2 15 2 decreased cytotoxic T cell cytolysis 0.548154245855475 0.714827620742067 0.597024626272839 0.411764705882353 15.2 15 2 increased susceptibility to viral infection induced morbidity/mortality 0.548154245855475 0.714827620742067 0.597024626272839 0.411764705882353 15.2 15 2 enlarged sebaceous gland 0.579549049363301 0.754779193869744 0.597024626272839 0.411764705882353 15.2 15 2 nephrocalcinosis 0.579549049363301 0.754779193869744 0.597024626272839 0.411764705882353 15.2 15 2 abnormal testis development 0.579549049363301 0.754779193869744 0.597024626272839 0.411764705882353 15.2 15 2 increased regulatory T cell number 0.579549049363301 0.754779193869744 0.597024626272839 0.411764705882353 15.2 15 2 abnormal humoral immune response 0.525995599760823 0.705073200664277 0.59377551266047 0.40952380952381 15.2 15 2 intestinal inflammation 0.577077393614527 0.752348017094411 0.593147842985353 0.409090909090909 15.2 15 2 increased susceptibility to bacterial infection induced morbidity/mortality 0.581624075604553 0.75728337506743 0.5839943268899 0.402777777777778 15.2 15 2 decreased monocyte cell number 0.599864359627774 0.772141057994354 0.579966779807901 0.4 15.2 15 2 abnormal estrous cycle 0.604701885975052 0.778166550110161 0.579966779807901 0.4 15.2 15 2 abnormal hair texture 0.613212492945131 0.784211565148925 0.579966779807901 0.4 15.2 15 2 arthritis 0.621884063231818 0.784211565148925 0.579966779807901 0.4 15.2 15 2 decreased skin tensile strength 0.613212492945131 0.784211565148925 0.579966779807901 0.4 15.2 15 2 abnormal thymocyte activation 0.613212492945131 0.784211565148925 0.579966779807901 0.4 15.2 15 2 decreased circulating VLDL cholesterol level 0.613212492945131 0.784211565148925 0.579966779807901 0.4 15.2 15 2 abnormal intestinal mucosa morphology 0.624496047412435 0.784211565148925 0.573222980042692 0.395348837209302 15.2 15 2 impaired macrophage phagocytosis 0.624496047412435 0.784211565148925 0.573222980042692 0.395348837209302 15.2 15 2 absent vibrissae 0.630479506103451 0.784211565148925 0.571179404356266 0.393939393939394 15.2 15 2 decreased systemic arterial blood pressure 0.630479506103451 0.784211565148925 0.571179404356266 0.393939393939394 15.2 15 2 abnormal T cell subpopulation ratio 0.630479506103451 0.784211565148925 0.571179404356266 0.393939393939394 15.2 15 2 abnormal spleen germinal center morphology 0.635274038210914 0.784211565148925 0.569610230168474 0.392857142857143 15.2 15 2 abnormal regulatory T cell physiology 0.642135519117118 0.784211565148925 0.567358806333816 0.391304347826087 15.2 15 2 increased susceptibility to fungal infection 0.642135519117118 0.784211565148925 0.567358806333816 0.391304347826087 15.2 15 2 increased B cell proliferation 0.65993229060722 0.795918338368708 0.565221861677191 0.389830508474576 15.2 15 2 abnormal stomach glandular epithelium morphology 0.652451232522433 0.787277439194544 0.563856591479903 0.388888888888889 15.2 15 2 abnormal inflammatory response 0.672585776596781 0.805807301051524 0.563856591479903 0.388888888888889 15.2 15 2 decreased urine osmolality 0.665885559367519 0.802903697977073 0.56221269471174 0.387755102040816 15.2 15 2 autoimmune response 0.659582747726664 0.795689662934082 0.561258174007646 0.387096774193548 15.2 15 2 abnormal photoreceptor outer segment morphology 0.669932191897749 0.805807301051524 0.560195185041722 0.386363636363636 15.2 15 2 abnormal membranous labyrinth morphology 0.669302029692936 0.805807301051524 0.557660365199904 0.384615384615385 15.2 15 2 decreased IgA level 0.68433322921262 0.813708846876861 0.557660365199904 0.384615384615385 15.2 15 2 abnormal leukocyte migration 0.68433322921262 0.813708846876861 0.557660365199904 0.384615384615385 15.2 15 2 increased acute inflammation 0.67849830550071 0.807156640331429 0.552349314102762 0.380952380952381 15.2 15 2 abnormal bile salt homeostasis 0.67849830550071 0.807156640331429 0.552349314102762 0.380952380952381 15.2 15 2 abnormal digestive system physiology 0.706349822678802 0.834899113287489 0.550968440817506 0.38 15.2 15 2 increased thymus weight 0.695108693422272 0.825732031942646 0.543718856069907 0.375 15.2 15 2 abnormal wound healing 0.695108693422272 0.825732031942646 0.543718856069907 0.375 15.2 15 2 abnormal level of surface class II molecules 0.695108693422272 0.825732031942646 0.543718856069907 0.375 15.2 15 2 increased heart left ventricle size 0.695108693422272 0.825732031942646 0.543718856069907 0.375 15.2 15 2 abnormal cellular extravasation 0.701172139384062 0.829348409243547 0.543718856069907 0.375 15.2 15 2 altered susceptibility to infection 0.717167884764123 0.847082200071584 0.534179928770435 0.368421052631579 15.2 15 2 osteoarthritis 0.717167884764123 0.847082200071584 0.534179928770435 0.368421052631579 15.2 15 2 increased left ventricle weight 0.717167884764123 0.847082200071584 0.534179928770435 0.368421052631579 15.2 15 2 decreased susceptibility to viral infection induced morbidity/mortality 0.736453112292816 0.86903563416906 0.527242527098091 0.363636363636364 15.2 15 2 increased systemic arterial blood pressure 0.786194565748556 0.904541837725424 0.524438045570974 0.361702127659574 15.2 15 2 decreased acute inflammation 0.753578894950231 0.88882290241285 0.521970101827111 0.36 15.2 15 2 abnormal leukocyte adhesion 0.783475435257893 0.904541837725424 0.520483007519911 0.358974358974359 15.2 15 2 increased lung compliance 0.741470538458332 0.87474885672995 0.51782748197134 0.357142857142857 15.2 15 2 abnormal cytotoxic T cell physiology 0.795830647338324 0.907878346825995 0.51782748197134 0.357142857142857 15.2 15 2 abnormal Peyer's patch T cell area morphology 0.773143864974349 0.904541837725424 0.507470932331913 0.35 15.2 15 2 nuclear cataracts 0.773143864974349 0.904541837725424 0.507470932331913 0.35 15.2 15 2 decreased susceptibility to parasitic infection 0.821127679306569 0.935664270396285 0.498408951397415 0.34375 15.2 15 2 joint inflammation 0.801263776071588 0.913657411404114 0.483305649839917 0.333333333333333 15.2 15 2 greasy coat 0.801263776071588 0.913657411404114 0.483305649839917 0.333333333333333 15.2 15 2 abnormal macrophage chemotaxis 0.810986223556803 0.924531728275687 0.483305649839917 0.333333333333333 15.2 15 2 increased vasoconstriction 0.820466644711168 0.935125213616967 0.483305649839917 0.333333333333333 15.2 15 2 abnormal stomach mucosa morphology 0.865297686623053 0.979935349635714 0.463973423846321 0.32 15.2 15 2 intestinal ulcer 0.859672959839733 0.973787107286582 0.46133721121083 0.318181818181818 15.2 15 2 impaired natural killer cell mediated cytotoxicity 0.94190325483012 1 0.457868510374658 0.315789473684211 15.2 15 2 abnormal pancreatic alpha cell morphology 0.849516086366732 0.965117600876495 0.453099046724922 0.3125 15.2 15 2 abnormal intestinal lipid absorption 0.849516086366732 0.965117600876495 0.453099046724922 0.3125 15.2 15 2 stomach inflammation 0.898116274063401 1 0.449974225713026 0.310344827586207 15.2 15 2 waved hair 0.88906262259281 0.994622565189842 0.434975084855926 0.3 15.2 15 2 abnormal circulating cytokine level 0.88906262259281 0.994622565189842 0.434975084855926 0.3 15.2 15 2 abnormal T cell proliferation 0.938218682303164 1 0.420943630505734 0.290322580645161 15.2 15 2 increased susceptibility to parasitic infection 0.993017826017097 1 0.418864896527928 0.288888888888889 15.2 15 2 abnormal iron level 0.91705152965212 1 0.402754708199931 0.277777777777778 15.2 15 2 impaired leukocyte tethering or rolling 0.91705152965212 1 0.402754708199931 0.277777777777778 15.2 15 2 decreased airway responsiveness 0.937811533960117 1 0.395431895323569 0.272727272727273 15.2 15 2 increased urine calcium level 0.956269038836103 1 0.362479237379938 0.25 15.2 15 2 increased susceptibility to induced arthritis 0.993751203077988 1 0.299982817142018 0.206896551724138 15.2 15 2 decreased macrophage cytokine production 2.33818401434877e-06 6.22264170007929e-05 2.65560344827586 1 16.2 16 2 mammary gland hyperplasia 0.0001144385384534 0.00178473896177324 2.65560344827586 1 16.2 16 2 abnormal circulating alanine transaminase level 0.0001144385384534 0.00178473896177324 2.65560344827586 1 16.2 16 2 heart hemorrhage 0.0001144385384534 0.00178473896177324 2.65560344827586 1 16.2 16 2 delayed brain development 0.000418538532161139 0.00535331477749525 2.65560344827586 1 16.2 16 2 enlarged pancreas 0.000418538532161139 0.00535331477749525 2.65560344827586 1 16.2 16 2 cerebral arteriovenous malformation 0.000418538532161139 0.00535331477749525 2.65560344827586 1 16.2 16 2 decreased macrophage nitric oxide production 0.000418538532161139 0.00535331477749525 2.65560344827586 1 16.2 16 2 gastric polyps 0.00153061007788395 0.0155721577453429 2.65560344827586 1 16.2 16 2 increased T follicular helper cell number 0.00153061007788395 0.0155721577453429 2.65560344827586 1 16.2 16 2 increased Schwann cell number 0.00153061007788395 0.0155721577453429 2.65560344827586 1 16.2 16 2 decreased level of surface class I molecules 0.000213162256872781 0.00310082522790083 2.36053639846743 0.888888888888889 16.2 16 2 decreased response to antigen 8.89332229895549e-06 0.000201110356533198 2.2762315270936 0.857142857142857 16.2 16 2 cellular necrosis 0.00224313849440757 0.0215504217603782 2.2762315270936 0.857142857142857 16.2 16 2 abnormal brain ventricular system morphology 0.00224313849440757 0.0215504217603782 2.2762315270936 0.857142857142857 16.2 16 2 decreased mortality induced by ionizing radiation 0.00224313849440757 0.0215504217603782 2.2762315270936 0.857142857142857 16.2 16 2 decreased DN2 thymocyte number 0.00224313849440757 0.0215504217603782 2.2762315270936 0.857142857142857 16.2 16 2 abnormal aorta tunica media morphology 2.80224218851576e-05 0.000542457388632915 2.24704907161804 0.846153846153846 16.2 16 2 increased effector memory CD8-positive, alpha-beta T cell number 1.1988945744233e-06 3.4476881547722e-05 2.21300287356322 0.833333333333333 16.2 16 2 decreased red blood cell distribution width 8.7233739259191e-05 0.00143230314460223 2.21300287356322 0.833333333333333 16.2 16 2 jumpy 0.00709096780649802 0.0503246288692263 2.21300287356322 0.833333333333333 16.2 16 2 absent ectoplacental cone 0.00709096780649802 0.0503246288692263 2.21300287356322 0.833333333333333 16.2 16 2 non-obstructive hydrocephaly 0.00709096780649802 0.0503246288692263 2.21300287356322 0.833333333333333 16.2 16 2 abnormal lymph node cortex morphology 0.00709096780649802 0.0503246288692263 2.21300287356322 0.833333333333333 16.2 16 2 chromatolysis 0.00709096780649802 0.0503246288692263 2.21300287356322 0.833333333333333 16.2 16 2 abnormal leukocyte tethering or rolling 0.00709096780649802 0.0503246288692263 2.21300287356322 0.833333333333333 16.2 16 2 abnormal physical strength 0.00709096780649802 0.0503246288692263 2.21300287356322 0.833333333333333 16.2 16 2 absent parietal bone 0.00709096780649802 0.0503246288692263 2.21300287356322 0.833333333333333 16.2 16 2 abnormal immature B cell morphology 0.00709096780649802 0.0503246288692263 2.21300287356322 0.833333333333333 16.2 16 2 abnormal thromboxane level 0.00709096780649802 0.0503246288692263 2.21300287356322 0.833333333333333 16.2 16 2 abnormal aorta tunica adventitia morphology 0.00709096780649802 0.0503246288692263 2.21300287356322 0.833333333333333 16.2 16 2 lymphoid hyperplasia 2.38749883946856e-09 1.21202109452613e-07 2.18138854679803 0.821428571428571 16.2 16 2 loss of cortex neurons 0.000267722556969274 0.00372044614782721 2.17276645768025 0.818181818181818 16.2 16 2 decreased mast cell number 1.1129660560711e-05 0.000247187773614005 2.15767780172414 0.8125 16.2 16 2 abnormal dendritic cell morphology 3.32942535572187e-05 0.000633581917690514 2.12448275862069 0.8 16.2 16 2 abnormal immune cell physiology 0.000807845855610526 0.00925451798906926 2.12448275862069 0.8 16.2 16 2 absent CD4-positive, alpha beta T cells 0.000807845855610526 0.00925451798906926 2.12448275862069 0.8 16.2 16 2 osteosclerosis 0.000807845855610526 0.00925451798906926 2.12448275862069 0.8 16.2 16 2 vascular smooth muscle hypoplasia 9.81624537012325e-05 0.00156024986314259 2.08654556650246 0.785714285714286 16.2 16 2 liver hyperplasia 0.00238815354892396 0.0223748849451915 2.065469348659 0.777777777777778 16.2 16 2 abnormal posterior eye segment morphology 0.00238815354892396 0.0223748849451915 2.065469348659 0.777777777777778 16.2 16 2 decreased transitional stage T1 B cell number 0.00238815354892396 0.0223748849451915 2.065469348659 0.777777777777778 16.2 16 2 decreased effector memory CD4-positive, alpha-beta T cell number 0.00238815354892396 0.0223748849451915 2.065469348659 0.777777777777778 16.2 16 2 lymphoid hypoplasia 0.000284604797172635 0.00390057538824755 2.04277188328913 0.769230769230769 16.2 16 2 increased prostaglandin level 0.000284604797172635 0.00390057538824755 2.04277188328913 0.769230769230769 16.2 16 2 impaired macrophage phagocytosis 2.25486032501823e-11 1.78062382808979e-09 2.03802125100241 0.767441860465116 16.2 16 2 abnormal level of surface class II molecules 9.9788032546742e-05 0.00157236009924435 1.9917025862069 0.75 16.2 16 2 enlarged pituitary gland 0.00688307301231115 0.0498446699217584 1.9917025862069 0.75 16.2 16 2 poor grooming 0.00688307301231115 0.0498446699217584 1.9917025862069 0.75 16.2 16 2 abnormal hepatobiliary system morphology 0.00688307301231115 0.0498446699217584 1.9917025862069 0.75 16.2 16 2 altered response to CNS ischemic injury 0.00688307301231115 0.0498446699217584 1.9917025862069 0.75 16.2 16 2 abnormal cellular cholesterol metabolism 0.00688307301231115 0.0498446699217584 1.9917025862069 0.75 16.2 16 2 colon polyps 0.00688307301231115 0.0498446699217584 1.9917025862069 0.75 16.2 16 2 abnormal kidney epithelium morphology 0.00688307301231115 0.0498446699217584 1.9917025862069 0.75 16.2 16 2 accumulation of giant lysosomes in kidney/renal tubule cells 0.00688307301231115 0.0498446699217584 1.9917025862069 0.75 16.2 16 2 abnormal NK cell morphology 0.00688307301231115 0.0498446699217584 1.9917025862069 0.75 16.2 16 2 abnormal epidermal lamellar body morphology 0.00688307301231115 0.0498446699217584 1.9917025862069 0.75 16.2 16 2 abnormal mitotic spindle assembly checkpoint 0.00688307301231115 0.0498446699217584 1.9917025862069 0.75 16.2 16 2 abnormal cerebellum deep nucleus morphology 0.00688307301231115 0.0498446699217584 1.9917025862069 0.75 16.2 16 2 abnormal maxillary prominence morphology 0.00688307301231115 0.0498446699217584 1.9917025862069 0.75 16.2 16 2 abnormal heart echocardiography feature 0.00688307301231115 0.0498446699217584 1.9917025862069 0.75 16.2 16 2 increased brain apoptosis 0.00688307301231115 0.0498446699217584 1.9917025862069 0.75 16.2 16 2 interstitial pneumonia 0.000809189010099524 0.00925451798906926 1.9917025862069 0.75 16.2 16 2 altered tumor susceptibility 0.000809189010099524 0.00925451798906926 1.9917025862069 0.75 16.2 16 2 abnormal rostral-caudal body axis extension 0.000809189010099524 0.00925451798906926 1.9917025862069 0.75 16.2 16 2 incomplete embryo turning 4.52531900495577e-13 4.41440432346176e-11 1.95676043557169 0.736842105263158 16.2 16 2 decreased B cell proliferation 2.11607431471275e-17 5.01308081699807e-15 1.9496835443038 0.734177215189873 16.2 16 2 abnormal lymph node B cell domain morphology 0.000276550004097271 0.0038111808043876 1.94744252873563 0.733333333333333 16.2 16 2 increased thymocyte apoptosis 1.60560196954349e-06 4.52190463790196e-05 1.94063328912467 0.730769230769231 16.2 16 2 delayed hepatic development 0.00224817465198719 0.0215504217603782 1.93134796238244 0.727272727272727 16.2 16 2 aorta dilation 0.00224817465198719 0.0215504217603782 1.93134796238244 0.727272727272727 16.2 16 2 abnormal megakaryocyte differentiation 9.52358520319085e-05 0.00152647484311099 1.91793582375479 0.722222222222222 16.2 16 2 abnormal Peyer's patch follicle morphology 9.52358520319085e-05 0.00152647484311099 1.91793582375479 0.722222222222222 16.2 16 2 increased adipocyte glucose uptake 9.52358520319085e-05 0.00152647484311099 1.91793582375479 0.722222222222222 16.2 16 2 increased fibroblast apoptosis 2.03662408356337e-07 7.45015059979984e-06 1.90871497844828 0.71875 16.2 16 2 abnormal spleen periarteriolar lymphoid sheath morphology 0.000750710655851143 0.00878773061849279 1.89685960591133 0.714285714285714 16.2 16 2 increased lactate dehydrogenase level 0.000750710655851143 0.00878773061849279 1.89685960591133 0.714285714285714 16.2 16 2 increased stomach tumor incidence 0.000750710655851143 0.00878773061849279 1.89685960591133 0.714285714285714 16.2 16 2 polyphalangy 0.0192105410867242 0.111650048956136 1.89685960591133 0.714285714285714 16.2 16 2 abnormal tumor incidence 0.0192105410867242 0.111650048956136 1.89685960591133 0.714285714285714 16.2 16 2 abnormal hypersensitivity reaction 0.0192105410867242 0.111650048956136 1.89685960591133 0.714285714285714 16.2 16 2 decreased cardiomyocyte apoptosis 0.0192105410867242 0.111650048956136 1.89685960591133 0.714285714285714 16.2 16 2 abnormal sinus venosus morphology 0.0192105410867242 0.111650048956136 1.89685960591133 0.714285714285714 16.2 16 2 increased cell nucleus count 0.0192105410867242 0.111650048956136 1.89685960591133 0.714285714285714 16.2 16 2 renal necrosis 0.0192105410867242 0.111650048956136 1.89685960591133 0.714285714285714 16.2 16 2 abnormal negative T cell selection 0.0192105410867242 0.111650048956136 1.89685960591133 0.714285714285714 16.2 16 2 abnormal MHC II cell surface expression on macrophages 0.0192105410867242 0.111650048956136 1.89685960591133 0.714285714285714 16.2 16 2 absent popliteal lymph nodes 0.0192105410867242 0.111650048956136 1.89685960591133 0.714285714285714 16.2 16 2 abnormal sperm annulus morphology 0.0192105410867242 0.111650048956136 1.89685960591133 0.714285714285714 16.2 16 2 decreased DN4 thymocyte number 0.0192105410867242 0.111650048956136 1.89685960591133 0.714285714285714 16.2 16 2 focal dorsal hair loss 0.0192105410867242 0.111650048956136 1.89685960591133 0.714285714285714 16.2 16 2 abnormal T wave 0.0192105410867242 0.111650048956136 1.89685960591133 0.714285714285714 16.2 16 2 abnormal conotruncal ridge morphology 0.0192105410867242 0.111650048956136 1.89685960591133 0.714285714285714 16.2 16 2 altered tumor pathology 0.0192105410867242 0.111650048956136 1.89685960591133 0.714285714285714 16.2 16 2 abnormal tricarboxylic acid cycle 0.0192105410867242 0.111650048956136 1.89685960591133 0.714285714285714 16.2 16 2 increased compact bone volume 0.0192105410867242 0.111650048956136 1.89685960591133 0.714285714285714 16.2 16 2 embryonic lethality at implantation, incomplete penetrance 0.0192105410867242 0.111650048956136 1.89685960591133 0.714285714285714 16.2 16 2 ductus venosus stenosis 0.0192105410867242 0.111650048956136 1.89685960591133 0.714285714285714 16.2 16 2 embryo tumor 0.0192105410867242 0.111650048956136 1.89685960591133 0.714285714285714 16.2 16 2 osteopetrosis 5.39534238114497e-07 1.71458248839138e-05 1.88462180200222 0.709677419354839 16.2 16 2 abnormal bone marrow cavity morphology 0.000254409404664411 0.00355529996686923 1.87454361054767 0.705882352941177 16.2 16 2 hyperlipidemia 0.000254409404664411 0.00355529996686923 1.87454361054767 0.705882352941177 16.2 16 2 abnormal circulating chemokine level 0.000254409404664411 0.00355529996686923 1.87454361054767 0.705882352941177 16.2 16 2 abnormal erythropoiesis 4.4166954958786e-20 1.46971379196445e-17 1.87156814449918 0.704761904761905 16.2 16 2 decreased platelet aggregation 5.83026282007318e-11 4.20370398983537e-09 1.86875798212005 0.703703703703704 16.2 16 2 increased mammary adenocarcinoma incidence 8.71343974601699e-05 0.00143230314460223 1.8589224137931 0.7 16.2 16 2 decreased myocardial infarction size 8.71343974601699e-05 0.00143230314460223 1.8589224137931 0.7 16.2 16 2 abnormal thymocyte activation 8.71343974601699e-05 0.00143230314460223 1.8589224137931 0.7 16.2 16 2 abnormal airway responsiveness 0.00607553816665531 0.0458661644599547 1.8589224137931 0.7 16.2 16 2 ketoaciduria 0.00607553816665531 0.0458661644599547 1.8589224137931 0.7 16.2 16 2 aneurysm 0.00607553816665531 0.0458661644599547 1.8589224137931 0.7 16.2 16 2 bifid ureter 0.00607553816665531 0.0458661644599547 1.8589224137931 0.7 16.2 16 2 abnormal embryonic erythrocyte morphology 0.00607553816665531 0.0458661644599547 1.8589224137931 0.7 16.2 16 2 abnormal gonadal fat pad morphology 0.00607553816665531 0.0458661644599547 1.8589224137931 0.7 16.2 16 2 absent inguinal lymph nodes 0.00607553816665531 0.0458661644599547 1.8589224137931 0.7 16.2 16 2 decreased transitional stage T2 B cell number 0.00607553816665531 0.0458661644599547 1.8589224137931 0.7 16.2 16 2 abnormal hippocampus neuron morphology 0.00607553816665531 0.0458661644599547 1.8589224137931 0.7 16.2 16 2 abnormal heart and great artery attachment 0.00607553816665531 0.0458661644599547 1.8589224137931 0.7 16.2 16 2 thin ventricle myocardium compact layer 0.00607553816665531 0.0458661644599547 1.8589224137931 0.7 16.2 16 2 thick aortic valve cusps 0.00607553816665531 0.0458661644599547 1.8589224137931 0.7 16.2 16 2 decreased macrophage apoptosis 0.00607553816665531 0.0458661644599547 1.8589224137931 0.7 16.2 16 2 lethality during fetal growth through weaning, complete penetrance 0.00607553816665531 0.0458661644599547 1.8589224137931 0.7 16.2 16 2 decreased circulating lactate level 0.00607553816665531 0.0458661644599547 1.8589224137931 0.7 16.2 16 2 abnormal coping response 0.00198950348918502 0.0195995640766247 1.83849469496021 0.692307692307692 16.2 16 2 increased fatty acid level 1.27845226358244e-06 3.63445714932723e-05 1.82572737068966 0.6875 16.2 16 2 increased lung adenocarcinoma incidence 9.90005216065523e-10 5.47252883325109e-08 1.82247295469912 0.686274509803922 16.2 16 2 abnormal triglyceride level 0.000225763235309031 0.00323680719211074 1.81699183303085 0.684210526315789 16.2 16 2 small superior vagus ganglion 0.000225763235309031 0.00323680719211074 1.81699183303085 0.684210526315789 16.2 16 2 altered susceptibility to infection 0.000225763235309031 0.00323680719211074 1.81699183303085 0.684210526315789 16.2 16 2 abnormal response to infection 3.75974278746519e-14 4.34993496921844e-12 1.81522261021388 0.683544303797468 16.2 16 2 impaired humoral immune response 7.73869409820746e-05 0.00130894786555194 1.81063871473354 0.681818181818182 16.2 16 2 abnormal cell nucleus morphology 7.0429926517135e-09 3.30555551342214e-07 1.80807043286867 0.680851063829787 16.2 16 2 abnormal egg cylinder morphology 2.67327578287256e-05 0.000521550863521215 1.80581034482759 0.68 16.2 16 2 increased B cell proliferation 1.13167043275802e-10 7.60818973374477e-09 1.80040911747516 0.677966101694915 16.2 16 2 abnormal lymphocyte physiology 1.76728616407882e-08 7.64543362286272e-07 1.78964580209895 0.673913043478261 16.2 16 2 abnormal cell cycle 9.64845743334605e-19 2.66672642949426e-16 1.77809970014993 0.669565217391304 16.2 16 2 spleen hyperplasia 1.45486460508909e-12 1.365651209494e-10 1.77040229885057 0.666666666666667 16.2 16 2 abnormal lysosome morphology 9.97612038727944e-07 2.91948228980678e-05 1.77040229885057 0.666666666666667 16.2 16 2 abnormal cellular respiration 8.11880692495458e-06 0.000185347577712921 1.77040229885057 0.666666666666667 16.2 16 2 abnormal thymus medulla morphology 0.000572756509929415 0.00694991130950937 1.77040229885057 0.666666666666667 16.2 16 2 absent inner cell mass 0.000572756509929415 0.00694991130950937 1.77040229885057 0.666666666666667 16.2 16 2 small thoracic cage 0.000572756509929415 0.00694991130950937 1.77040229885057 0.666666666666667 16.2 16 2 increased effector memory CD4-positive, alpha-beta T cell number 0.000572756509929415 0.00694991130950937 1.77040229885057 0.666666666666667 16.2 16 2 abnormal hypoglossal nerve topology 0.000572756509929415 0.00694991130950937 1.77040229885057 0.666666666666667 16.2 16 2 decreased hepatocyte number 0.00169903195935888 0.0170074124704435 1.77040229885057 0.666666666666667 16.2 16 2 abnormal placenta size 0.00169903195935888 0.0170074124704435 1.77040229885057 0.666666666666667 16.2 16 2 abnormal trophectoderm morphology 0.00169903195935888 0.0170074124704435 1.77040229885057 0.666666666666667 16.2 16 2 decreased thymocyte apoptosis 0.00169903195935888 0.0170074124704435 1.77040229885057 0.666666666666667 16.2 16 2 abnormal kindling response 0.0158729119390856 0.0973708223143657 1.77040229885057 0.666666666666667 16.2 16 2 abnormal thymus lobule morphology 0.0158729119390856 0.0973708223143657 1.77040229885057 0.666666666666667 16.2 16 2 decreased fear-related response 0.0158729119390856 0.0973708223143657 1.77040229885057 0.666666666666667 16.2 16 2 abnormal thymus physiology 0.0158729119390856 0.0973708223143657 1.77040229885057 0.666666666666667 16.2 16 2 decreased cellular sensitivity to ionizing radiation 0.0158729119390856 0.0973708223143657 1.77040229885057 0.666666666666667 16.2 16 2 positive geotaxis 0.0158729119390856 0.0973708223143657 1.77040229885057 0.666666666666667 16.2 16 2 absent cervical lymph nodes 0.0158729119390856 0.0973708223143657 1.77040229885057 0.666666666666667 16.2 16 2 eye opacity 0.0158729119390856 0.0973708223143657 1.77040229885057 0.666666666666667 16.2 16 2 abnormal ventricle myocardium morphology 0.0158729119390856 0.0973708223143657 1.77040229885057 0.666666666666667 16.2 16 2 increased myeloid cell number 0.0158729119390856 0.0973708223143657 1.77040229885057 0.666666666666667 16.2 16 2 abnormal infrahyoid muscle connection 0.0158729119390856 0.0973708223143657 1.77040229885057 0.666666666666667 16.2 16 2 decreased platelet dense granule number 0.0158729119390856 0.0973708223143657 1.77040229885057 0.666666666666667 16.2 16 2 decreased metastatic potential 6.72505369590839e-05 0.00115414911356947 1.77040229885057 0.666666666666667 16.2 16 2 amyloidosis 0.00512614593576253 0.0414006597337485 1.77040229885057 0.666666666666667 16.2 16 2 abnormal thymus involution 0.00512614593576253 0.0414006597337485 1.77040229885057 0.666666666666667 16.2 16 2 small intestinal inflammation 0.00512614593576253 0.0414006597337485 1.77040229885057 0.666666666666667 16.2 16 2 increased osteosarcoma incidence 0.00512614593576253 0.0414006597337485 1.77040229885057 0.666666666666667 16.2 16 2 abnormal B cell proliferation 0.00512614593576253 0.0414006597337485 1.77040229885057 0.666666666666667 16.2 16 2 abnormal fatty acid level 0.00512614593576253 0.0414006597337485 1.77040229885057 0.666666666666667 16.2 16 2 increased fibrosarcoma incidence 0.00512614593576253 0.0414006597337485 1.77040229885057 0.666666666666667 16.2 16 2 persistent right dorsal aorta 0.00512614593576253 0.0414006597337485 1.77040229885057 0.666666666666667 16.2 16 2 abnormal pulmonary valve cusp morphology 0.00512614593576253 0.0414006597337485 1.77040229885057 0.666666666666667 16.2 16 2 prenatal growth retardation 0.00512614593576253 0.0414006597337485 1.77040229885057 0.666666666666667 16.2 16 2 increased B cell derived lymphoma incidence 1.35868473609991e-08 6.03522907330092e-07 1.75269827586207 0.66 16.2 16 2 abnormal cell morphology 1.25083834928485e-17 3.11146039384606e-15 1.74710753176044 0.657894736842105 16.2 16 2 decreased IgG level 3.47859959172958e-17 7.21084707035612e-15 1.7464779434607 0.657657657657658 16.2 16 2 abnormal embryonic erythropoiesis 2.00119713119755e-05 0.000401527822383674 1.73987812128419 0.655172413793103 16.2 16 2 abnormal leukocyte cell number 5.74905240250114e-05 0.000996569188238438 1.73635610079576 0.653846153846154 16.2 16 2 increased leukemia incidence 5.74905240250114e-05 0.000996569188238438 1.73635610079576 0.653846153846154 16.2 16 2 failure to gastrulate 9.31031302216519e-08 3.59060521591254e-06 1.73191529235382 0.652173913043478 16.2 16 2 abnormal Peyer's patch T cell area morphology 0.000483216791314059 0.00604020989142573 1.72614224137931 0.65 16.2 16 2 dilated vasculature 0.000483216791314059 0.00604020989142573 1.72614224137931 0.65 16.2 16 2 increased skin tumor incidence 0.000483216791314059 0.00604020989142573 1.72614224137931 0.65 16.2 16 2 decreased IgM level 1.21232852878118e-14 1.5464960078683e-12 1.72477337362247 0.649484536082474 16.2 16 2 enlarged spleen 1.42109873693487e-40 1.1783277027085e-37 1.72429807231801 0.649305555555556 16.2 16 2 decreased susceptibility to induced arthritis 3.60655510604188e-09 1.74200113131634e-07 1.7238127646703 0.649122807017544 16.2 16 2 impaired hematopoiesis 2.83603034145787e-08 1.17577091239608e-06 1.71833164300203 0.647058823529412 16.2 16 2 abnormal spleen red pulp morphology 5.96374050267122e-06 0.000143331444448258 1.71833164300203 0.647058823529412 16.2 16 2 increased susceptibility to viral infection induced morbidity/mortality 5.96374050267122e-06 0.000143331444448258 1.71833164300203 0.647058823529412 16.2 16 2 abnormal ectoplacental cone morphology 0.00141895739238914 0.0146155549216066 1.71833164300203 0.647058823529412 16.2 16 2 increased brain size 0.00141895739238914 0.0146155549216066 1.71833164300203 0.647058823529412 16.2 16 2 increased trabecular bone mass 0.00141895739238914 0.0146155549216066 1.71833164300203 0.647058823529412 16.2 16 2 abnormal T cell proliferation 1.69814049220419e-05 0.000346239711012945 1.71329254727475 0.645161290322581 16.2 16 2 decreased susceptibility to bacterial infection induced morbidity/mortality 1.69814049220419e-05 0.000346239711012945 1.71329254727475 0.645161290322581 16.2 16 2 straub tail 4.85276614178714e-05 0.000863662899334486 1.7071736453202 0.642857142857143 16.2 16 2 abnormal blood flow velocity 0.004219330589186 0.0359437837006855 1.7071736453202 0.642857142857143 16.2 16 2 abnormal antigen presentation 0.004219330589186 0.0359437837006855 1.7071736453202 0.642857142857143 16.2 16 2 failure of zygotic cell division 0.004219330589186 0.0359437837006855 1.7071736453202 0.642857142857143 16.2 16 2 increased B-1 B cell number 0.004219330589186 0.0359437837006855 1.7071736453202 0.642857142857143 16.2 16 2 testis degeneration 0.004219330589186 0.0359437837006855 1.7071736453202 0.642857142857143 16.2 16 2 small liver 1.33510515608416e-11 1.0888767461506e-09 1.70230990274094 0.641025641025641 16.2 16 2 abnormal leukocyte adhesion 1.78108406472532e-06 4.92271845667137e-05 1.70230990274094 0.641025641025641 16.2 16 2 abnormal cytokine secretion 5.29667930035916e-21 2.19591495994057e-18 1.68992946708464 0.636363636363636 16.2 16 2 abnormal platelet physiology 2.04676814334562e-08 8.62938263825802e-07 1.68992946708464 0.636363636363636 16.2 16 2 abnormal T cell subpopulation ratio 1.4271664264704e-05 0.000300853939478401 1.68992946708464 0.636363636363636 16.2 16 2 myeloid hyperplasia 1.4271664264704e-05 0.000300853939478401 1.68992946708464 0.636363636363636 16.2 16 2 increased myocardial infarction size 0.000401911380510231 0.00523431706292775 1.68992946708464 0.636363636363636 16.2 16 2 abnormal vascular branching morphogenesis 0.000401911380510231 0.00523431706292775 1.68992946708464 0.636363636363636 16.2 16 2 decreased susceptibility to viral infection induced morbidity/mortality 0.000401911380510231 0.00523431706292775 1.68992946708464 0.636363636363636 16.2 16 2 increased adenoma incidence 0.000401911380510231 0.00523431706292775 1.68992946708464 0.636363636363636 16.2 16 2 embryonic lethality before implantation, incomplete penetrance 0.000401911380510231 0.00523431706292775 1.68992946708464 0.636363636363636 16.2 16 2 decreased atrioventricular cushion size 0.0127734243173245 0.082422549907509 1.68992946708464 0.636363636363636 16.2 16 2 abnormal food preference 0.0127734243173245 0.082422549907509 1.68992946708464 0.636363636363636 16.2 16 2 impaired myelopoiesis 0.0127734243173245 0.082422549907509 1.68992946708464 0.636363636363636 16.2 16 2 abnormal proximal-distal axis patterning 0.0127734243173245 0.082422549907509 1.68992946708464 0.636363636363636 16.2 16 2 vasculitis 0.0127734243173245 0.082422549907509 1.68992946708464 0.636363636363636 16.2 16 2 pharyngeal arch hypoplasia 0.0127734243173245 0.082422549907509 1.68992946708464 0.636363636363636 16.2 16 2 increased glycogen level 0.0127734243173245 0.082422549907509 1.68992946708464 0.636363636363636 16.2 16 2 hypolactation 0.0127734243173245 0.082422549907509 1.68992946708464 0.636363636363636 16.2 16 2 reduced sympathetic cervical ganglion size 0.0127734243173245 0.082422549907509 1.68992946708464 0.636363636363636 16.2 16 2 abnormal dendritic cell physiology 5.56129506324958e-15 8.3840736180808e-13 1.68767321946503 0.635514018691589 16.2 16 2 pale liver 8.75585377973524e-11 6.13526374002575e-09 1.68666705498602 0.635135135135135 16.2 16 2 decreased susceptibility to hepatic steatosis 2.22407959590927e-09 1.14070061748955e-07 1.68609742747674 0.634920634920635 16.2 16 2 salivary gland inflammation 4.05547097986482e-05 0.000742008459217121 1.68188218390805 0.633333333333333 16.2 16 2 abnormal spleen marginal zone morphology 4.05547097986482e-05 0.000742008459217121 1.68188218390805 0.633333333333333 16.2 16 2 extramedullary hematopoiesis 1.30234956207236e-14 1.6197972678275e-12 1.6785418022121 0.632075471698113 16.2 16 2 increased inflammatory response 3.24879564750197e-13 3.29852211149434e-11 1.67722323049002 0.631578947368421 16.2 16 2 abnormal blastocyst morphology 0.00116760212356437 0.0123591926909207 1.67722323049002 0.631578947368421 16.2 16 2 increased circulating VLDL cholesterol level 0.00116760212356437 0.0123591926909207 1.67722323049002 0.631578947368421 16.2 16 2 increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 0.00116760212356437 0.0123591926909207 1.67722323049002 0.631578947368421 16.2 16 2 abnormal trigeminal ganglion morphology 0.000115607984719988 0.00179734288744356 1.6720466155811 0.62962962962963 16.2 16 2 increased carcinoma incidence 1.19001053205901e-05 0.000259662385833052 1.66923645320197 0.628571428571429 16.2 16 2 decreased T cell proliferation 1.86336258557382e-19 5.7938930395186e-17 1.66872378844362 0.628378378378378 16.2 16 2 abnormal vasculogenesis 1.25322287256139e-06 3.58320907528329e-05 1.66747193263833 0.627906976744186 16.2 16 2 decreased lymphocyte cell number 9.60020872252407e-17 1.91044153578229e-14 1.65975215517241 0.625 16.2 16 2 abnormal embryonic hematopoiesis 3.36212314111147e-05 0.000633581917690514 1.65975215517241 0.625 16.2 16 2 decreased susceptibility to parasitic infection 3.36212314111147e-05 0.000633581917690514 1.65975215517241 0.625 16.2 16 2 increased intestinal adenocarcinoma incidence 0.00342170798910964 0.0303982093675365 1.65975215517241 0.625 16.2 16 2 decreased liver cholesterol level 0.00342170798910964 0.0303982093675365 1.65975215517241 0.625 16.2 16 2 abnormal ear pigmentation 0.0397563212107458 0.185716148378836 1.65975215517241 0.625 16.2 16 2 spinning 0.0397563212107458 0.185716148378836 1.65975215517241 0.625 16.2 16 2 abnormal erythrocyte cell number 0.0397563212107458 0.185716148378836 1.65975215517241 0.625 16.2 16 2 liver failure 0.0397563212107458 0.185716148378836 1.65975215517241 0.625 16.2 16 2 increased cardiac output 0.0397563212107458 0.185716148378836 1.65975215517241 0.625 16.2 16 2 elevated level of mitotic sister chromatid exchange 0.0397563212107458 0.185716148378836 1.65975215517241 0.625 16.2 16 2 binucleate 0.0397563212107458 0.185716148378836 1.65975215517241 0.625 16.2 16 2 abnormal extraembryonic tissue physiology 0.0397563212107458 0.185716148378836 1.65975215517241 0.625 16.2 16 2 absent interparietal bone 0.0397563212107458 0.185716148378836 1.65975215517241 0.625 16.2 16 2 abnormal optic choroid morphology 0.0397563212107458 0.185716148378836 1.65975215517241 0.625 16.2 16 2 abnormal choroid pigmentation 0.0397563212107458 0.185716148378836 1.65975215517241 0.625 16.2 16 2 abnormal somite size 0.0397563212107458 0.185716148378836 1.65975215517241 0.625 16.2 16 2 ocular hypertension 0.0397563212107458 0.185716148378836 1.65975215517241 0.625 16.2 16 2 stomach epithelial hyperplasia 0.0397563212107458 0.185716148378836 1.65975215517241 0.625 16.2 16 2 choroidal neovascularization 0.0397563212107458 0.185716148378836 1.65975215517241 0.625 16.2 16 2 abnormal base-excision repair 0.0397563212107458 0.185716148378836 1.65975215517241 0.625 16.2 16 2 abnormal sphingomyelin level 0.0397563212107458 0.185716148378836 1.65975215517241 0.625 16.2 16 2 abnormal olfactory bulb mitral cell layer morphology 0.0397563212107458 0.185716148378836 1.65975215517241 0.625 16.2 16 2 increased caudal vertebrae number 0.0397563212107458 0.185716148378836 1.65975215517241 0.625 16.2 16 2 pleural effusion 0.0397563212107458 0.185716148378836 1.65975215517241 0.625 16.2 16 2 delayed suture closure 0.0397563212107458 0.185716148378836 1.65975215517241 0.625 16.2 16 2 increased aorta wall thickness 0.0397563212107458 0.185716148378836 1.65975215517241 0.625 16.2 16 2 lethality during fetal growth through weaning, incomplete penetrance 0.0397563212107458 0.185716148378836 1.65975215517241 0.625 16.2 16 2 increased circulating ferritin level 0.0397563212107458 0.185716148378836 1.65975215517241 0.625 16.2 16 2 increased testis apoptosis 0.0397563212107458 0.185716148378836 1.65975215517241 0.625 16.2 16 2 absent hypoglossal canal 0.0397563212107458 0.185716148378836 1.65975215517241 0.625 16.2 16 2 abnormal umbilical vein topology 0.0397563212107458 0.185716148378836 1.65975215517241 0.625 16.2 16 2 embryo cyst 0.0397563212107458 0.185716148378836 1.65975215517241 0.625 16.2 16 2 decreased white adipose tissue mass 0.0397563212107458 0.185716148378836 1.65975215517241 0.625 16.2 16 2 vertebral transformation 3.73550349690699e-07 1.25568445250758e-05 1.65975215517241 0.625 16.2 16 2 increased hemangiosarcoma incidence 0.000330809251359833 0.00448440333927839 1.65975215517241 0.625 16.2 16 2 abnormal cellular extravasation 0.000330809251359833 0.00448440333927839 1.65975215517241 0.625 16.2 16 2 increased B cell number 2.37629154881676e-15 3.69439076730106e-13 1.65691497200118 0.623931623931624 16.2 16 2 decreased birth body size 6.53070911904373e-15 9.55596407860076e-13 1.65392846339988 0.62280701754386 16.2 16 2 abnormal T cell activation 3.97915441432309e-10 2.35670157276873e-08 1.65078052190121 0.621621621621622 16.2 16 2 abnormal CD8-positive, alpha-beta T cell physiology 9.51896997729738e-05 0.00152647484311099 1.64830558858502 0.620689655172414 16.2 16 2 decreased double-positive T cell number 4.44607505474969e-13 4.41440432346176e-11 1.64647413793103 0.62 16.2 16 2 abnormal eye pigmentation 0.000950925856564162 0.0105130136364593 1.64394499178982 0.619047619047619 16.2 16 2 abnormal erythrocyte physiology 0.000950925856564162 0.0105130136364593 1.64394499178982 0.619047619047619 16.2 16 2 increased acute inflammation 0.000950925856564162 0.0105130136364593 1.64394499178982 0.619047619047619 16.2 16 2 decreased mean corpuscular hemoglobin 3.02626568557247e-09 1.49066057284386e-07 1.64022565922921 0.617647058823529 16.2 16 2 decreased embryo size 2.98268666356495e-56 1.48388661512356e-52 1.63891844611167 0.617154811715481 16.2 16 2 distended pericardium 2.56780786045436e-07 8.9334574166157e-06 1.6342175066313 0.615384615384615 16.2 16 2 liver hypoplasia 2.56780786045436e-07 8.9334574166157e-06 1.6342175066313 0.615384615384615 16.2 16 2 abnormal leukocyte migration 2.56780786045436e-07 8.9334574166157e-06 1.6342175066313 0.615384615384615 16.2 16 2 decreased Peyer's patch number 0.000270148736745036 0.00374370463873692 1.6342175066313 0.615384615384615 16.2 16 2 increased pituitary adenoma incidence 0.0101447738502866 0.0682953314007789 1.6342175066313 0.615384615384615 16.2 16 2 axonal dystrophy 0.0101447738502866 0.0682953314007789 1.6342175066313 0.615384615384615 16.2 16 2 increased circulating thyroxine level 0.0101447738502866 0.0682953314007789 1.6342175066313 0.615384615384615 16.2 16 2 absent hypoglossal nerve 0.0101447738502866 0.0682953314007789 1.6342175066313 0.615384615384615 16.2 16 2 abnormal B cell differentiation 9.18293494143774e-12 7.74323751417843e-10 1.6342175066313 0.615384615384615 16.2 16 2 increased autoantibody level 8.12176320430488e-06 0.000185347577712921 1.6342175066313 0.615384615384615 16.2 16 2 impaired macrophage chemotaxis 8.12176320430488e-06 0.000185347577712921 1.6342175066313 0.615384615384615 16.2 16 2 increased hepatocyte apoptosis 8.12176320430488e-06 0.000185347577712921 1.6342175066313 0.615384615384615 16.2 16 2 decreased B-1 B cell number 8.12176320430488e-06 0.000185347577712921 1.6342175066313 0.615384615384615 16.2 16 2 abnormal capillary morphology 7.78791091866081e-05 0.00130894786555194 1.62762791991101 0.612903225806452 16.2 16 2 inner cell mass degeneration 7.78791091866081e-05 0.00130894786555194 1.62762791991101 0.612903225806452 16.2 16 2 abnormal CD8-positive, alpha beta T cell morphology 7.78791091866081e-05 0.00130894786555194 1.62762791991101 0.612903225806452 16.2 16 2 abnormal cell adhesion 2.11668777969139e-07 7.68651219267494e-06 1.62286877394636 0.611111111111111 16.2 16 2 abnormal trophoblast giant cell morphology 2.26866881225436e-05 0.000447882037339898 1.62286877394636 0.611111111111111 16.2 16 2 decreased cellular sensitivity to gamma-irradiation 0.00274870163625443 0.0254183960351154 1.62286877394636 0.611111111111111 16.2 16 2 abnormal neutrophil morphology 0.00274870163625443 0.0254183960351154 1.62286877394636 0.611111111111111 16.2 16 2 abnormal macrophage chemotaxis 0.00274870163625443 0.0254183960351154 1.62286877394636 0.611111111111111 16.2 16 2 increased spleen weight 6.43989896542593e-14 7.11966607844311e-12 1.62156316753128 0.610619469026549 16.2 16 2 abnormal cell differentiation 6.66043962384743e-06 0.000157788986326862 1.61927039529016 0.609756097560976 16.2 16 2 increased bone trabecula number 6.66043962384743e-06 0.000157788986326862 1.61927039529016 0.609756097560976 16.2 16 2 abnormal cell death 1.96718123951686e-06 5.37732234428373e-05 1.61645427286357 0.608695652173913 16.2 16 2 increased bone resorption 0.000219277575277803 0.00317123818897405 1.61233066502463 0.607142857142857 16.2 16 2 abnormal brainstem morphology 0.000219277575277803 0.00317123818897405 1.61233066502463 0.607142857142857 16.2 16 2 increased tumor incidence 1.10034516407509e-14 1.44058347138778e-12 1.60621176307008 0.604838709677419 16.2 16 2 abnormal osteoclast morphology 1.6087982329822e-06 4.52190463790196e-05 1.60442708333333 0.604166666666667 16.2 16 2 atrioventricular septal defect 4.77880970165841e-07 1.55389400429742e-05 1.60338321405335 0.60377358490566 16.2 16 2 abnormal liver physiology 7.87294701200619e-12 6.75308816978117e-10 1.59336206896552 0.6 16.2 16 2 abnormal keratinocyte physiology 0.000618099911946668 0.00742764990805477 1.59336206896552 0.6 16.2 16 2 abnormal preimplantation embryo development 0.000618099911946668 0.00742764990805477 1.59336206896552 0.6 16.2 16 2 abnormal microglial cell physiology 0.000177142184734464 0.00264649360076263 1.59336206896552 0.6 16.2 16 2 abnormal physiological neovascularization 0.00219418012193983 0.0214040119738248 1.59336206896552 0.6 16.2 16 2 decreased salivation 0.0079997785339267 0.055507528879059 1.59336206896552 0.6 16.2 16 2 increased airway responsiveness 0.0079997785339267 0.055507528879059 1.59336206896552 0.6 16.2 16 2 delayed intramembranous bone ossification 0.0079997785339267 0.055507528879059 1.59336206896552 0.6 16.2 16 2 liver vascular congestion 0.0079997785339267 0.055507528879059 1.59336206896552 0.6 16.2 16 2 abnormal microglial cell activation 0.0079997785339267 0.055507528879059 1.59336206896552 0.6 16.2 16 2 decreased trabecular bone mass 0.0079997785339267 0.055507528879059 1.59336206896552 0.6 16.2 16 2 heterochrony 0.0079997785339267 0.055507528879059 1.59336206896552 0.6 16.2 16 2 decreased brown adipose tissue mass 0.0079997785339267 0.055507528879059 1.59336206896552 0.6 16.2 16 2 fused cornea and lens 0.030568972597731 0.152691404290875 1.59336206896552 0.6 16.2 16 2 absent trophoblast giant cells 0.030568972597731 0.152691404290875 1.59336206896552 0.6 16.2 16 2 abnormal mammary gland physiology 0.030568972597731 0.152691404290875 1.59336206896552 0.6 16.2 16 2 abnormal respiratory mechanics 0.030568972597731 0.152691404290875 1.59336206896552 0.6 16.2 16 2 acrania 0.030568972597731 0.152691404290875 1.59336206896552 0.6 16.2 16 2 abnormal scala media morphology 0.030568972597731 0.152691404290875 1.59336206896552 0.6 16.2 16 2 peritoneal inflammation 0.030568972597731 0.152691404290875 1.59336206896552 0.6 16.2 16 2 increased atrioventricular cushion size 0.030568972597731 0.152691404290875 1.59336206896552 0.6 16.2 16 2 abnormal gas homeostasis 0.030568972597731 0.152691404290875 1.59336206896552 0.6 16.2 16 2 abnormal plasma membrane morphology 0.030568972597731 0.152691404290875 1.59336206896552 0.6 16.2 16 2 increased susceptibility to atherosclerosis 0.030568972597731 0.152691404290875 1.59336206896552 0.6 16.2 16 2 absent axillary lymph nodes 0.030568972597731 0.152691404290875 1.59336206896552 0.6 16.2 16 2 increased circulating fructosamine level 0.030568972597731 0.152691404290875 1.59336206896552 0.6 16.2 16 2 acanthocytosis 0.030568972597731 0.152691404290875 1.59336206896552 0.6 16.2 16 2 aorta stenosis 0.030568972597731 0.152691404290875 1.59336206896552 0.6 16.2 16 2 abnormal left subclavian artery morphology 0.030568972597731 0.152691404290875 1.59336206896552 0.6 16.2 16 2 abnormal inferior vena cava valve morphology 0.030568972597731 0.152691404290875 1.59336206896552 0.6 16.2 16 2 fusion of atlas and odontoid process 0.030568972597731 0.152691404290875 1.59336206896552 0.6 16.2 16 2 increased compact bone area 0.030568972597731 0.152691404290875 1.59336206896552 0.6 16.2 16 2 abnormal adaptive thermogenesis 0.030568972597731 0.152691404290875 1.59336206896552 0.6 16.2 16 2 increased fatty acid oxidation 0.030568972597731 0.152691404290875 1.59336206896552 0.6 16.2 16 2 abnormal T-helper 2 physiology 3.90083893364225e-07 1.30246132180337e-05 1.59336206896552 0.6 16.2 16 2 decreased triglyceride level 5.13802332583154e-05 0.000900058663591968 1.59336206896552 0.6 16.2 16 2 increased susceptibility to bacterial infection induced morbidity/mortality 8.5343061652235e-09 3.85983392472608e-07 1.58598539272031 0.597222222222222 16.2 16 2 pericardial effusion 9.4892802783061e-08 3.63147456804407e-06 1.58479560622914 0.596774193548387 16.2 16 2 decreased hemoglobin content 1.02107856213855e-15 1.63866640214171e-13 1.58206162876009 0.595744680851064 16.2 16 2 abnormal spleen white pulp morphology 1.21777316533931e-05 0.000264559890723277 1.58071633825944 0.595238095238095 16.2 16 2 increased granulocyte number 6.95588793242695e-09 3.29576594893562e-07 1.57900745573159 0.594594594594595 16.2 16 2 increased trabecular bone volume 4.15020942423812e-05 0.000756311058080025 1.57900745573159 0.594594594594595 16.2 16 2 abnormal osteoclast physiology 7.71888490255054e-08 3.02373640867629e-06 1.57676454741379 0.59375 16.2 16 2 abnormal atrioventricular cushion morphology 0.000494935285145104 0.00617118557292455 1.57369093231162 0.592592592592593 16.2 16 2 embryonic lethality, complete penetrance 4.49279672345295e-33 2.7939579623973e-30 1.5733826072857 0.592476489028213 16.2 16 2 increased circulating LDL cholesterol level 2.9107839967317e-06 7.46451050708258e-05 1.57168367346939 0.591836734693878 16.2 16 2 increased sarcoma incidence 2.9107839967317e-06 7.46451050708258e-05 1.57168367346939 0.591836734693878 16.2 16 2 decreased sensitivity to induced morbidity/mortality 9.83692463823284e-06 0.000220444594933371 1.56922021943574 0.590909090909091 16.2 16 2 abnormal germ layer development 0.00174394676641984 0.0173522703258774 1.56922021943574 0.590909090909091 16.2 16 2 increased skin papilloma incidence 0.00174394676641984 0.0173522703258774 1.56922021943574 0.590909090909091 16.2 16 2 increased bone volume 0.00174394676641984 0.0173522703258774 1.56922021943574 0.590909090909091 16.2 16 2 failure of heart looping 3.34266006022801e-05 0.000633581917690514 1.56612511052166 0.58974358974359 16.2 16 2 abnormal trophoblast layer morphology 2.35147063239177e-06 6.22264170007929e-05 1.56211967545639 0.588235294117647 16.2 16 2 failure of chorioallantoic fusion 2.35147063239177e-06 6.22264170007929e-05 1.56211967545639 0.588235294117647 16.2 16 2 absence seizures 0.0062827802701389 0.0468618168574828 1.56211967545639 0.588235294117647 16.2 16 2 increased regulatory T cell number 0.0062827802701389 0.0468618168574828 1.56211967545639 0.588235294117647 16.2 16 2 thymus hypoplasia 1.06709738386464e-14 1.43481337425043e-12 1.55872376311844 0.58695652173913 16.2 16 2 thrombocytosis 5.65738347463162e-07 1.7813596700185e-05 1.55673305588585 0.586206896551724 16.2 16 2 lordosis 0.000395068732242979 0.00522338362294346 1.55673305588585 0.586206896551724 16.2 16 2 decreased granulocyte number 0.000395068732242979 0.00522338362294346 1.55673305588585 0.586206896551724 16.2 16 2 liver fibrosis 2.68573287592293e-05 0.000521934416317053 1.55449957947855 0.585365853658537 16.2 16 2 decreased inflammatory response 2.4436155907862e-09 1.22797854183448e-07 1.54910201149425 0.583333333333333 16.2 16 2 abnormal nursing 0.00138187264375069 0.0143524350786214 1.54910201149425 0.583333333333333 16.2 16 2 increased body temperature 0.00138187264375069 0.0143524350786214 1.54910201149425 0.583333333333333 16.2 16 2 abnormal pilomotor reflex 0.0234796140515113 0.122829737020261 1.54910201149425 0.583333333333333 16.2 16 2 myocarditis 0.0234796140515113 0.122829737020261 1.54910201149425 0.583333333333333 16.2 16 2 increased papilloma incidence 0.0234796140515113 0.122829737020261 1.54910201149425 0.583333333333333 16.2 16 2 abnormal embryonic growth/weight/body size 0.0234796140515113 0.122829737020261 1.54910201149425 0.583333333333333 16.2 16 2 increased growth rate 0.0234796140515113 0.122829737020261 1.54910201149425 0.583333333333333 16.2 16 2 decreased synaptic depression 0.0234796140515113 0.122829737020261 1.54910201149425 0.583333333333333 16.2 16 2 abnormal vascular endothelial cell development 0.0234796140515113 0.122829737020261 1.54910201149425 0.583333333333333 16.2 16 2 delayed somite formation 0.0234796140515113 0.122829737020261 1.54910201149425 0.583333333333333 16.2 16 2 abnormal thymus corticomedullary boundary morphology 0.0234796140515113 0.122829737020261 1.54910201149425 0.583333333333333 16.2 16 2 embryonic lethality between implantation and placentation, incomplete penetrance 0.0234796140515113 0.122829737020261 1.54910201149425 0.583333333333333 16.2 16 2 abnormal vitelline vein connection 0.0234796140515113 0.122829737020261 1.54910201149425 0.583333333333333 16.2 16 2 abnormal immune system physiology 6.62435958505284e-13 6.33772864146883e-11 1.54196329254727 0.580645161290323 16.2 16 2 increased eosinophil cell number 3.67474048737661e-07 1.24366217174821e-05 1.54196329254727 0.580645161290323 16.2 16 2 preaxial polydactyly 0.000314583366262261 0.00428781437576643 1.54196329254727 0.580645161290323 16.2 16 2 increased monocyte cell number 1.1842094710846e-10 7.8552561581945e-09 1.54025 0.58 16.2 16 2 increased lymphocyte cell number 8.89165222269177e-08 3.45593514124153e-06 1.53948025987006 0.579710144927536 16.2 16 2 decreased erythrocyte cell number 7.47633925740627e-16 1.32838527877129e-13 1.5392351197013 0.579617834394904 16.2 16 2 increased T cell proliferation 2.90682216270893e-11 2.22483696299645e-09 1.53876087657106 0.579439252336449 16.2 16 2 increased neutrophil cell number 9.92649761242878e-15 1.3717868228287e-12 1.53841854934602 0.579310344827586 16.2 16 2 abnormal stationary movement 0.00492271346620327 0.040671931195167 1.53745462794918 0.578947368421053 16.2 16 2 decreased tumor incidence 0.00492271346620327 0.040671931195167 1.53745462794918 0.578947368421053 16.2 16 2 decreased eye pigmentation 0.00492271346620327 0.040671931195167 1.53745462794918 0.578947368421053 16.2 16 2 increased liver cholesterol level 0.00492271346620327 0.040671931195167 1.53745462794918 0.578947368421053 16.2 16 2 abnormal myocardial trabeculae morphology 1.7237124143113e-05 0.000350019153518314 1.53434865900383 0.577777777777778 16.2 16 2 pallor 2.97607429436216e-17 6.43737809323989e-15 1.53266256157635 0.577142857142857 16.2 16 2 ventricular hypoplasia 0.00109257878722162 0.0117908448295609 1.53207891246684 0.576923076923077 16.2 16 2 decreased circulating glycerol level 0.00109257878722162 0.0117908448295609 1.53207891246684 0.576923076923077 16.2 16 2 pulmonary edema 0.00109257878722162 0.0117908448295609 1.53207891246684 0.576923076923077 16.2 16 2 decreased bone resorption 0.00109257878722162 0.0117908448295609 1.53207891246684 0.576923076923077 16.2 16 2 embryonic growth arrest 5.07598547079609e-22 2.29572979247368e-19 1.53074085228128 0.576419213973799 16.2 16 2 increased cardiomyocyte apoptosis 0.000250013997429165 0.00352356837736571 1.52898380355277 0.575757575757576 16.2 16 2 decreased sensitivity to xenobiotic induced morbidity/mortality 0.000250013997429165 0.00352356837736571 1.52898380355277 0.575757575757576 16.2 16 2 decreased bone marrow cell number 5.75130259264265e-08 2.30747825793526e-06 1.52788143599433 0.575342465753425 16.2 16 2 abnormal T-helper 1 physiology 1.37763976416105e-05 0.000294152696424946 1.52555942773294 0.574468085106383 16.2 16 2 increased osteoclast cell number 7.88930431550999e-07 2.37874478604013e-05 1.52370689655172 0.573770491803279 16.2 16 2 abnormal NK cell physiology 7.88930431550999e-07 2.37874478604013e-05 1.52370689655172 0.573770491803279 16.2 16 2 pericardial edema 1.90474247803348e-07 7.07171181210191e-06 1.52306668356998 0.573529411764706 16.2 16 2 increased leukocyte cell number 3.63199397562538e-14 4.3021833401753e-12 1.52010404280618 0.572413793103448 16.2 16 2 embryonic lethality at implantation, complete penetrance 0.00385185247577404 0.033384958304836 1.51748768472906 0.571428571428571 16.2 16 2 abnormal humoral immune response 1.31946995654928e-10 8.41585004337519e-09 1.51748768472906 0.571428571428571 16.2 16 2 abnormal liver development 0.000198394679429876 0.00291154433676588 1.51748768472906 0.571428571428571 16.2 16 2 abnormal embryonic epiblast morphology 0.000198394679429876 0.00291154433676588 1.51748768472906 0.571428571428571 16.2 16 2 increased red blood cell distribution width 0.000198394679429876 0.00291154433676588 1.51748768472906 0.571428571428571 16.2 16 2 abnormal spleen germinal center morphology 0.000862478898301506 0.00977410596594531 1.51748768472906 0.571428571428571 16.2 16 2 subcutaneous edema 0.000862478898301506 0.00977410596594531 1.51748768472906 0.571428571428571 16.2 16 2 absent visceral yolk sac blood islands 0.0180453648650873 0.107773937819699 1.51748768472906 0.571428571428571 16.2 16 2 abnormal adrenal gland secretion 0.0180453648650873 0.107773937819699 1.51748768472906 0.571428571428571 16.2 16 2 increased hemangioma incidence 0.0180453648650873 0.107773937819699 1.51748768472906 0.571428571428571 16.2 16 2 amyloid beta deposits 0.0180453648650873 0.107773937819699 1.51748768472906 0.571428571428571 16.2 16 2 abnormal vascular endothelial cell migration 0.0180453648650873 0.107773937819699 1.51748768472906 0.571428571428571 16.2 16 2 abnormal maternal decidual layer morphology 0.0180453648650873 0.107773937819699 1.51748768472906 0.571428571428571 16.2 16 2 decreased CNS synapse formation 0.0180453648650873 0.107773937819699 1.51748768472906 0.571428571428571 16.2 16 2 increased pulmonary respiratory rate 0.0180453648650873 0.107773937819699 1.51748768472906 0.571428571428571 16.2 16 2 embryonic lethality during organogenesis, complete penetrance 8.92222033747597e-50 2.21940230894715e-46 1.51274553571429 0.569642857142857 16.2 16 2 abnormal myelopoiesis 3.69270120747901e-05 0.000690646184481507 1.50886559561129 0.568181818181818 16.2 16 2 decreased blood urea nitrogen level 3.69270120747901e-05 0.000690646184481507 1.50886559561129 0.568181818181818 16.2 16 2 abnormal chromosome morphology 0.00015724064309379 0.00239960797359389 1.50723438956198 0.567567567567568 16.2 16 2 increased metastatic potential 0.000680049602061809 0.00807457463068615 1.50484195402299 0.566666666666667 16.2 16 2 pale yolk sac 1.90335721429513e-08 8.16310529406747e-07 1.50377544661404 0.566265060240964 16.2 16 2 abnormal immune system morphology 2.93395269241061e-05 0.000561400563259337 1.50099325337331 0.565217391304348 16.2 16 2 abnormal allantois morphology 2.93395269241061e-05 0.000561400563259337 1.50099325337331 0.565217391304348 16.2 16 2 dilated heart 0.00301169953178614 0.0273416152748833 1.50099325337331 0.565217391304348 16.2 16 2 abnormal chondrocyte physiology 0.00301169953178614 0.0273416152748833 1.50099325337331 0.565217391304348 16.2 16 2 abnormal hematopoietic stem cell physiology 0.00301169953178614 0.0273416152748833 1.50099325337331 0.565217391304348 16.2 16 2 decreased B cell number 1.91924323635657e-18 5.02538689519681e-16 1.49538834951456 0.563106796116505 16.2 16 2 disorganized yolk sac vascular plexus 0.0138858692344058 0.0883404084925431 1.49377693965517 0.5625 16.2 16 2 white spotting 0.0138858692344058 0.0883404084925431 1.49377693965517 0.5625 16.2 16 2 abnormal epicardium morphology 0.0138858692344058 0.0883404084925431 1.49377693965517 0.5625 16.2 16 2 large intestinal inflammation 0.0138858692344058 0.0883404084925431 1.49377693965517 0.5625 16.2 16 2 abnormal Langerhans cell physiology 0.0138858692344058 0.0883404084925431 1.49377693965517 0.5625 16.2 16 2 increased hepatocellular carcinoma incidence 4.4197753492573e-06 0.000110494383731433 1.4908650937689 0.56140350877193 16.2 16 2 impaired natural killer cell mediated cytotoxicity 4.4197753492573e-06 0.000110494383731433 1.4908650937689 0.56140350877193 16.2 16 2 hemopericardium 9.84987948550916e-05 0.0015606098866372 1.48972876366695 0.560975609756098 16.2 16 2 spontaneous skin ulceration 0.00235394702968309 0.022221795963327 1.48713793103448 0.56 16.2 16 2 increased pre-B cell number 0.00235394702968309 0.022221795963327 1.48713793103448 0.56 16.2 16 2 enlarged liver sinusoidal spaces 0.000421808923171485 0.00535331477749525 1.48401369168357 0.558823529411765 16.2 16 2 abnormal oocyte morphology 0.000421808923171485 0.00535331477749525 1.48401369168357 0.558823529411765 16.2 16 2 abnormal direction of heart looping 0.000421808923171485 0.00535331477749525 1.48401369168357 0.558823529411765 16.2 16 2 lethality throughout fetal growth and development, incomplete penetrance 8.53648459561728e-16 1.41563369543987e-13 1.48357734540551 0.558659217877095 16.2 16 2 abnormal hepatocyte morphology 2.37545143379349e-10 1.45899640532378e-08 1.4833100341721 0.558558558558559 16.2 16 2 abnormal double-strand DNA break repair 7.78767033760848e-05 0.00130894786555194 1.48219727345629 0.558139534883721 16.2 16 2 decreased IgA level 1.46476062683256e-05 0.000307476123143122 1.48100961538462 0.557692307692308 16.2 16 2 embryonic lethality between somite formation and embryo turning, complete penetrance 5.36149387625139e-07 1.71458248839138e-05 1.47955049261084 0.557142857142857 16.2 16 2 decreased neutrophil cell number 1.20666458673758e-10 7.89888989344666e-09 1.47533524904215 0.555555555555556 16.2 16 2 hydrops fetalis 4.26208321684754e-07 1.40422940422626e-05 1.47533524904215 0.555555555555556 16.2 16 2 neurodegeneration 1.16060715951621e-05 0.000254362141788243 1.47533524904215 0.555555555555556 16.2 16 2 axon degeneration 1.16060715951621e-05 0.000254362141788243 1.47533524904215 0.555555555555556 16.2 16 2 abnormal mammary gland morphology 0.0107003785624945 0.0708846649113317 1.47533524904215 0.555555555555556 16.2 16 2 abnormal iron level 0.0107003785624945 0.0708846649113317 1.47533524904215 0.555555555555556 16.2 16 2 abnormal bile duct morphology 0.0107003785624945 0.0708846649113317 1.47533524904215 0.555555555555556 16.2 16 2 abnormal white adipose tissue morphology 0.0107003785624945 0.0708846649113317 1.47533524904215 0.555555555555556 16.2 16 2 abnormal metacarpal bone morphology 0.0107003785624945 0.0708846649113317 1.47533524904215 0.555555555555556 16.2 16 2 abnormal redox activity 0.0107003785624945 0.0708846649113317 1.47533524904215 0.555555555555556 16.2 16 2 decreased lactate dehydrogenase level 0.0107003785624945 0.0708846649113317 1.47533524904215 0.555555555555556 16.2 16 2 abnormal pregnancy 0.0107003785624945 0.0708846649113317 1.47533524904215 0.555555555555556 16.2 16 2 decreased tumor latency 0.0107003785624945 0.0708846649113317 1.47533524904215 0.555555555555556 16.2 16 2 abnormal aerobic respiration 0.0107003785624945 0.0708846649113317 1.47533524904215 0.555555555555556 16.2 16 2 impaired leukocyte tethering or rolling 0.0107003785624945 0.0708846649113317 1.47533524904215 0.555555555555556 16.2 16 2 heart hyperplasia 0.069610582800321 0.263636921914927 1.47533524904215 0.555555555555556 16.2 16 2 distorted hair follicle pattern 0.069610582800321 0.263636921914927 1.47533524904215 0.555555555555556 16.2 16 2 abnormal urinary bladder urothelium morphology 0.069610582800321 0.263636921914927 1.47533524904215 0.555555555555556 16.2 16 2 multifocal hepatic necrosis 0.069610582800321 0.263636921914927 1.47533524904215 0.555555555555556 16.2 16 2 increased pheochromocytoma incidence 0.069610582800321 0.263636921914927 1.47533524904215 0.555555555555556 16.2 16 2 polycythemia 0.069610582800321 0.263636921914927 1.47533524904215 0.555555555555556 16.2 16 2 abnormal artery development 0.069610582800321 0.263636921914927 1.47533524904215 0.555555555555556 16.2 16 2 premature bone ossification 0.069610582800321 0.263636921914927 1.47533524904215 0.555555555555556 16.2 16 2 decreased susceptibility to induced choroidal neovascularization 0.069610582800321 0.263636921914927 1.47533524904215 0.555555555555556 16.2 16 2 decreased cochlear hair cell number 0.069610582800321 0.263636921914927 1.47533524904215 0.555555555555556 16.2 16 2 increased neuronal precursor cell number 0.069610582800321 0.263636921914927 1.47533524904215 0.555555555555556 16.2 16 2 abnormal inguinal fat pad morphology 0.069610582800321 0.263636921914927 1.47533524904215 0.555555555555556 16.2 16 2 decreased susceptibility to atherosclerosis 0.069610582800321 0.263636921914927 1.47533524904215 0.555555555555556 16.2 16 2 abnormal leukopoiesis 0.069610582800321 0.263636921914927 1.47533524904215 0.555555555555556 16.2 16 2 enhanced conditioned place preference behavior 0.069610582800321 0.263636921914927 1.47533524904215 0.555555555555556 16.2 16 2 multiflagellated sperm 0.069610582800321 0.263636921914927 1.47533524904215 0.555555555555556 16.2 16 2 axonal spheroids 0.069610582800321 0.263636921914927 1.47533524904215 0.555555555555556 16.2 16 2 abnormal incisor color 0.069610582800321 0.263636921914927 1.47533524904215 0.555555555555556 16.2 16 2 iris coloboma 0.069610582800321 0.263636921914927 1.47533524904215 0.555555555555556 16.2 16 2 abnormal lung lobe morphology 0.069610582800321 0.263636921914927 1.47533524904215 0.555555555555556 16.2 16 2 decreased bone trabecular spacing 0.069610582800321 0.263636921914927 1.47533524904215 0.555555555555556 16.2 16 2 trigeminal neuroma 0.069610582800321 0.263636921914927 1.47533524904215 0.555555555555556 16.2 16 2 abnormal ductus venosus valve topology 0.069610582800321 0.263636921914927 1.47533524904215 0.555555555555556 16.2 16 2 altered response to myocardial infarction 6.15393719893869e-05 0.00106304991544167 1.47533524904215 0.555555555555556 16.2 16 2 increased cellular sensitivity to gamma-irradiation 4.86081631786243e-05 0.000863662899334486 1.4690572267058 0.553191489361702 16.2 16 2 neuron degeneration 4.86081631786243e-05 0.000863662899334486 1.4690572267058 0.553191489361702 16.2 16 2 decreased T cell number 7.37349521526128e-14 7.97459536867932e-12 1.46800439066181 0.552795031055901 16.2 16 2 decreased neuron apoptosis 0.000261147552742229 0.0036392411061417 1.46757032667877 0.552631578947368 16.2 16 2 abnormal spleen morphology 9.26334404799695e-15 1.31671818967957e-12 1.46516052318668 0.551724137931034 16.2 16 2 increased double-positive T cell number 0.00143775294883508 0.0147480843720712 1.46516052318668 0.551724137931034 16.2 16 2 blood in lymph vessels 0.00143775294883508 0.0147480843720712 1.46516052318668 0.551724137931034 16.2 16 2 embryonic lethality between implantation and somite formation, complete penetrance 4.43129786521946e-20 1.46971379196445e-17 1.46329169598874 0.551020408163265 16.2 16 2 liver inflammation 1.56735735346374e-10 9.74700354185263e-09 1.46058189655172 0.55 16.2 16 2 absent mesoderm 5.75885559341183e-06 0.000139757593059629 1.46058189655172 0.55 16.2 16 2 abnormal pericardium morphology 0.00825758755363635 0.0570576362213068 1.46058189655172 0.55 16.2 16 2 absent placental labyrinth 0.00825758755363635 0.0570576362213068 1.46058189655172 0.55 16.2 16 2 absent ductus venosus valve 0.00825758755363635 0.0570576362213068 1.46058189655172 0.55 16.2 16 2 anemia 2.30458483688329e-17 5.21150434704289e-15 1.45995260663507 0.549763033175355 16.2 16 2 small cranium 0.00112383003124697 0.0121018493624539 1.45629866518354 0.548387096774194 16.2 16 2 decreased hematocrit 2.4409911504285e-12 2.20798744970578e-10 1.45512517713746 0.547945205479452 16.2 16 2 astrocytosis 6.94064950414483e-07 2.144703806405e-05 1.45512517713746 0.547945205479452 16.2 16 2 abnormal vitelline vasculature morphology 5.04041256071648e-10 2.92663880020685e-08 1.45480884557721 0.547826086956522 16.2 16 2 abnormal cytotoxic T cell physiology 0.00016152929006347 0.00243517641838111 1.45425903119869 0.547619047619048 16.2 16 2 decreased macrophage cell number 0.000127016332937639 0.00195636611877633 1.44851097178683 0.545454545454545 16.2 16 2 abnormal skeleton physiology 0.000878636522621675 0.00991205600916742 1.44851097178683 0.545454545454545 16.2 16 2 abnormal chorion morphology 0.00638133932699908 0.0473132088700751 1.44851097178683 0.545454545454545 16.2 16 2 abnormal mesenteric lymph node morphology 0.00638133932699908 0.0473132088700751 1.44851097178683 0.545454545454545 16.2 16 2 pulmonary vascular congestion 0.00638133932699908 0.0473132088700751 1.44851097178683 0.545454545454545 16.2 16 2 increased mammary gland tumor incidence 0.00638133932699908 0.0473132088700751 1.44851097178683 0.545454545454545 16.2 16 2 abnormal stomach epithelium morphology 0.0519236305342187 0.222115272491606 1.44851097178683 0.545454545454545 16.2 16 2 abnormal eye distance/ position 0.0519236305342187 0.222115272491606 1.44851097178683 0.545454545454545 16.2 16 2 abnormal hemoglobin 0.0519236305342187 0.222115272491606 1.44851097178683 0.545454545454545 16.2 16 2 abnormal fear/anxiety-related behavior 0.0519236305342187 0.222115272491606 1.44851097178683 0.545454545454545 16.2 16 2 abnormal vestibular ganglion morphology 0.0519236305342187 0.222115272491606 1.44851097178683 0.545454545454545 16.2 16 2 retinal detachment 0.0519236305342187 0.222115272491606 1.44851097178683 0.545454545454545 16.2 16 2 abnormal spinal cord ventral horn morphology 0.0519236305342187 0.222115272491606 1.44851097178683 0.545454545454545 16.2 16 2 abnormal Bruch membrane morphology 0.0519236305342187 0.222115272491606 1.44851097178683 0.545454545454545 16.2 16 2 abnormal aorta smooth muscle morphology 0.0519236305342187 0.222115272491606 1.44851097178683 0.545454545454545 16.2 16 2 palatal shelf hypoplasia 0.0519236305342187 0.222115272491606 1.44851097178683 0.545454545454545 16.2 16 2 abnormal palatal shelf elevation 0.0519236305342187 0.222115272491606 1.44851097178683 0.545454545454545 16.2 16 2 increased number of Howell-Jolly bodies 0.0519236305342187 0.222115272491606 1.44851097178683 0.545454545454545 16.2 16 2 abnormal extraembryonic ectoderm morphology 0.0519236305342187 0.222115272491606 1.44851097178683 0.545454545454545 16.2 16 2 abnormal dendritic cell chemotaxis 0.0519236305342187 0.222115272491606 1.44851097178683 0.545454545454545 16.2 16 2 abnormal pulmonary alveolar sac morphology 0.0519236305342187 0.222115272491606 1.44851097178683 0.545454545454545 16.2 16 2 thin hypoglossal nerve 0.0519236305342187 0.222115272491606 1.44851097178683 0.545454545454545 16.2 16 2 oxidative stress 5.31726111032059e-08 2.15068081494674e-06 1.4458285440613 0.544444444444444 16.2 16 2 lung inflammation 2.4983204361851e-11 1.94205377656576e-09 1.44496069979716 0.544117647058823 16.2 16 2 increased macrophage cell number 1.48816065298649e-05 0.000311075598680999 1.44427555958863 0.543859649122807 16.2 16 2 abnormal myelin sheath morphology 9.98725208766262e-05 0.00157236009924435 1.44326274362819 0.543478260869565 16.2 16 2 abnormal neural tube closure 2.16027523935593e-07 7.73192037107608e-06 1.43978500207727 0.542168674698795 16.2 16 2 double outlet right ventricle 4.11283372495795e-09 1.96743728669863e-07 1.43948598130841 0.542056074766355 16.2 16 2 overriding aortic valve 7.85282036368395e-05 0.00131541351209857 1.43845186781609 0.541666666666667 16.2 16 2 hemolytic anemia 0.00493785858128259 0.040671931195167 1.43845186781609 0.541666666666667 16.2 16 2 abnormal tumor morphology 0.00493785858128259 0.040671931195167 1.43845186781609 0.541666666666667 16.2 16 2 abnormal retinal ganglion layer morphology 0.00493785858128259 0.040671931195167 1.43845186781609 0.541666666666667 16.2 16 2 increased double-negative T cell number 9.25804713386123e-06 0.000208410789551853 1.43663793103448 0.540983606557377 16.2 16 2 edema 1.22896958406868e-13 1.30087737888121e-11 1.43587860866079 0.540697674418605 16.2 16 2 increased erythroid progenitor cell number 0.000537488315583706 0.00663524657575419 1.43546132339236 0.540540540540541 16.2 16 2 skin inflammation 0.000537488315583706 0.00663524657575419 1.43546132339236 0.540540540540541 16.2 16 2 prenatal lethality, complete penetrance 5.85391146906965e-21 2.24024688912473e-18 1.43287955842223 0.539568345323741 16.2 16 2 decreased monocyte cell number 5.75762060189469e-06 0.000139757593059629 1.42994031830239 0.538461538461538 16.2 16 2 kinked neural tube 4.85521805650769e-05 0.000863662899334486 1.42994031830239 0.538461538461538 16.2 16 2 abnormal response to injury 0.000420568991338072 0.00535331477749525 1.42994031830239 0.538461538461538 16.2 16 2 abnormal Schwann cell morphology 0.00382554331255478 0.0332147957765445 1.42994031830239 0.538461538461538 16.2 16 2 increased susceptibility to otitis media 0.00382554331255478 0.0332147957765445 1.42994031830239 0.538461538461538 16.2 16 2 abnormal nerve conduction 0.00382554331255478 0.0332147957765445 1.42994031830239 0.538461538461538 16.2 16 2 absent teeth 0.0390369276196068 0.185716148378836 1.42994031830239 0.538461538461538 16.2 16 2 absent common myeloid progenitor cells 0.0390369276196068 0.185716148378836 1.42994031830239 0.538461538461538 16.2 16 2 increased foot pad pigmentation 0.0390369276196068 0.185716148378836 1.42994031830239 0.538461538461538 16.2 16 2 abnormal telomere length 0.0390369276196068 0.185716148378836 1.42994031830239 0.538461538461538 16.2 16 2 abnormal exocrine pancreas morphology 0.0390369276196068 0.185716148378836 1.42994031830239 0.538461538461538 16.2 16 2 increased circulating ammonia level 0.0390369276196068 0.185716148378836 1.42994031830239 0.538461538461538 16.2 16 2 orthokeratosis 0.0390369276196068 0.185716148378836 1.42994031830239 0.538461538461538 16.2 16 2 abnormal definitive hematopoiesis 6.69594410519984e-08 2.64383507328327e-06 1.42774378939562 0.537634408602151 16.2 16 2 decreased tumor growth/size 3.81793251704089e-05 0.00071139379296923 1.42615740740741 0.537037037037037 16.2 16 2 embryonic lethality before implantation, complete penetrance 5.05911430789526e-10 2.92663880020685e-08 1.42340344827586 0.536 16.2 16 2 abnormal circulating cholesterol level 0.00296711885695084 0.0270851675473953 1.4226447044335 0.535714285714286 16.2 16 2 abnormal mitotic spindle morphology 0.00296711885695084 0.0270851675473953 1.4226447044335 0.535714285714286 16.2 16 2 abnormal CD4-positive, alpha-beta T cell physiology 2.82277919138173e-06 7.3142325401688e-05 1.42130888780962 0.535211267605634 16.2 16 2 increased T cell number 2.13438426630619e-07 7.69460994556034e-06 1.41833365987461 0.534090909090909 16.2 16 2 disorganized myocardium 0.00230369963086168 0.0218719573731619 1.41632183908046 0.533333333333333 16.2 16 2 liver hemorrhage 0.00230369963086168 0.0218719573731619 1.41632183908046 0.533333333333333 16.2 16 2 abnormal brain vasculature morphology 0.00230369963086168 0.0218719573731619 1.41632183908046 0.533333333333333 16.2 16 2 abnormal fat pad morphology 0.00230369963086168 0.0218719573731619 1.41632183908046 0.533333333333333 16.2 16 2 macrocytosis 0.0295260349578422 0.150658486066939 1.41632183908046 0.533333333333333 16.2 16 2 abnormal pericyte morphology 0.0295260349578422 0.150658486066939 1.41632183908046 0.533333333333333 16.2 16 2 immune system phenotype 0.0295260349578422 0.150658486066939 1.41632183908046 0.533333333333333 16.2 16 2 abnormal coronary vessel morphology 0.0295260349578422 0.150658486066939 1.41632183908046 0.533333333333333 16.2 16 2 spleen hypoplasia 1.63643316957999e-08 7.14145177075477e-07 1.41632183908046 0.533333333333333 16.2 16 2 abnormal ectoderm development 0.000201847145449928 0.00294483738596302 1.41632183908046 0.533333333333333 16.2 16 2 abnormal cell migration 0.000201847145449928 0.00294483738596302 1.41632183908046 0.533333333333333 16.2 16 2 abnormal heart development 6.09672014408488e-12 5.3212601257583e-10 1.41183980794413 0.531645569620253 16.2 16 2 abnormal placenta morphology 1.09100028233436e-06 3.15565488640317e-05 1.41183980794413 0.531645569620253 16.2 16 2 abnormal nervous system morphology 1.09100028233436e-06 3.15565488640317e-05 1.41183980794413 0.531645569620253 16.2 16 2 lethality throughout fetal growth and development, complete penetrance 4.73768647717856e-14 5.35681595999167e-12 1.41166288566243 0.531578947368421 16.2 16 2 abnormal heart atrium morphology 0.00179031902326253 0.0177427034675918 1.41078933189655 0.53125 16.2 16 2 thrombocytopenia 4.88284744066515e-11 3.6256964204939e-09 1.41021700356718 0.531034482758621 16.2 16 2 abnormal respiratory system physiology 0.000123912622689169 0.00191448850272861 1.40909570724842 0.530612244897959 16.2 16 2 decreased cell proliferation 1.48476763743857e-13 1.53889979088685e-11 1.40675209692451 0.52972972972973 16.2 16 2 small lung 9.71278137011261e-05 0.00154875279859969 1.40590770791075 0.529411764705882 16.2 16 2 abnormal brown adipose tissue morphology 0.00139256757200314 0.0144333826473242 1.40590770791075 0.529411764705882 16.2 16 2 abnormal adipose tissue morphology 0.022439344319206 0.119780834751126 1.40590770791075 0.529411764705882 16.2 16 2 abnormal interatrial septum morphology 0.022439344319206 0.119780834751126 1.40590770791075 0.529411764705882 16.2 16 2 abnormal dorsal-ventral axis patterning 0.022439344319206 0.119780834751126 1.40590770791075 0.529411764705882 16.2 16 2 decreased vasoconstriction 0.022439344319206 0.119780834751126 1.40590770791075 0.529411764705882 16.2 16 2 abnormal embryonic-extraembryonic boundary morphology 0.022439344319206 0.119780834751126 1.40590770791075 0.529411764705882 16.2 16 2 coloboma 0.022439344319206 0.119780834751126 1.40590770791075 0.529411764705882 16.2 16 2 enhanced behavioral response to cocaine 0.022439344319206 0.119780834751126 1.40590770791075 0.529411764705882 16.2 16 2 abnormal ductus venosus valve morphology 0.022439344319206 0.119780834751126 1.40590770791075 0.529411764705882 16.2 16 2 anophthalmia 3.32527776470842e-07 1.13309978626194e-05 1.40239732661759 0.528089887640449 16.2 16 2 abnormal pharyngeal arch morphology 0.00108406167789115 0.0117908448295609 1.40156848659004 0.527777777777778 16.2 16 2 incomplete somite formation 0.000844533607629792 0.00961454164292498 1.39768602540835 0.526315789473684 16.2 16 2 increased malignant tumor incidence 0.0171200064472625 0.103489710905384 1.39768602540835 0.526315789473684 16.2 16 2 increased susceptibility to ischemic brain injury 0.0171200064472625 0.103489710905384 1.39768602540835 0.526315789473684 16.2 16 2 decreased liver regeneration 0.0171200064472625 0.103489710905384 1.39768602540835 0.526315789473684 16.2 16 2 decreased susceptibility to weight gain 0.0171200064472625 0.103489710905384 1.39768602540835 0.526315789473684 16.2 16 2 embryonic lethality between implantation and somite formation, incomplete penetrance 0.0171200064472625 0.103489710905384 1.39768602540835 0.526315789473684 16.2 16 2 increased embryonic tissue cell apoptosis 2.1476410530879e-06 5.83853237109962e-05 1.39589412024757 0.525641025641026 16.2 16 2 abnormal retinal pigment epithelium morphology 1.69065507266984e-06 4.69888770197344e-05 1.39419181034483 0.525 16.2 16 2 preweaning lethality, complete penetrance 4.05569723693229e-48 6.72569791791271e-45 1.39239748369059 0.524324324324324 16.2 16 2 liver degeneration 0.013103896139285 0.084010158882658 1.39103037766831 0.523809523809524 16.2 16 2 abnormal tumor vascularization 0.013103896139285 0.084010158882658 1.39103037766831 0.523809523809524 16.2 16 2 absent segment of posterior cerebral artery 0.013103896139285 0.084010158882658 1.39103037766831 0.523809523809524 16.2 16 2 internal hemorrhage 1.3963559426819e-05 0.000296874821147113 1.38725553268142 0.522388059701492 16.2 16 2 increased susceptibility to parasitic infection 5.11752825834508e-07 1.65322747306927e-05 1.38681513409962 0.522222222222222 16.2 16 2 abnormal locomotor behavior 4.03053859099099e-07 1.33679529934534e-05 1.38553223388306 0.521739130434783 16.2 16 2 embryonic lethality between implantation and placentation, complete penetrance 0.000313092190438984 0.00427921331712622 1.38553223388306 0.521739130434783 16.2 16 2 abnormal B cell morphology 0.0100573100126859 0.0680749895416494 1.38553223388306 0.521739130434783 16.2 16 2 increased susceptibility to fungal infection 0.0100573100126859 0.0680749895416494 1.38553223388306 0.521739130434783 16.2 16 2 small heart 0.000244648417555448 0.00348746669724456 1.38312679597701 0.520833333333333 16.2 16 2 abnormal lymph node morphology 0.000244648417555448 0.00348746669724456 1.38312679597701 0.520833333333333 16.2 16 2 short stride length 0.000191259583689025 0.00284885158339192 1.38091379310345 0.52 16.2 16 2 increased cellular sensitivity to ionizing radiation 0.00773709609551539 0.0543673066033744 1.38091379310345 0.52 16.2 16 2 decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 0.00773709609551539 0.0543673066033744 1.38091379310345 0.52 16.2 16 2 abnormal eye muscle morphology 0.00596421577934906 0.0458661644599547 1.37697956577267 0.518518518518518 16.2 16 2 decreased circulating fructosamine level 0.00596421577934906 0.0458661644599547 1.37697956577267 0.518518518518518 16.2 16 2 decreased leukocyte cell number 1.11797669314492e-09 6.11201543779777e-08 1.37626164107727 0.518248175182482 16.2 16 2 dermatitis 7.1746195020195e-05 0.00122658872929715 1.37358799048751 0.517241379310345 16.2 16 2 abnormal microglial cell morphology 0.00460572518707486 0.0388364115350804 1.37358799048751 0.517241379310345 16.2 16 2 increased susceptibility to induced arthritis 0.00460572518707486 0.0388364115350804 1.37358799048751 0.517241379310345 16.2 16 2 decreased bone strength 0.00460572518707486 0.0388364115350804 1.37358799048751 0.517241379310345 16.2 16 2 abnormal embryonic tissue morphology 3.41818912494051e-10 2.04885432488904e-08 1.3729650480882 0.517006802721088 16.2 16 2 increased grip strength 7.78308515878428e-07 2.37874478604013e-05 1.37157540735127 0.516483516483517 16.2 16 2 decreased double-negative T cell number 0.00356222720378404 0.0315901610317747 1.3706340378198 0.516129032258065 16.2 16 2 enlarged pericardium 0.00275898168019343 0.0254183960351154 1.3680381400209 0.515151515151515 16.2 16 2 decreased brown adipose tissue amount 0.00275898168019343 0.0254183960351154 1.3680381400209 0.515151515151515 16.2 16 2 abnormal QRS complex 0.00275898168019343 0.0254183960351154 1.3680381400209 0.515151515151515 16.2 16 2 abnormal embryo development 2.14068653236319e-09 1.10936619776113e-07 1.36685471602434 0.514705882352941 16.2 16 2 ventricular septal defect 2.14068653236319e-09 1.10936619776113e-07 1.36685471602434 0.514705882352941 16.2 16 2 domed cranium 1.66544099592683e-05 0.000342378882427106 1.36573891625616 0.514285714285714 16.2 16 2 thick pulmonary interalveolar septum 0.00213951911429683 0.02091180273797 1.36573891625616 0.514285714285714 16.2 16 2 abnormal hippocampus pyramidal cell morphology 0.00213951911429683 0.02091180273797 1.36573891625616 0.514285714285714 16.2 16 2 decreased bone volume 0.00213951911429683 0.02091180273797 1.36573891625616 0.514285714285714 16.2 16 2 abnormal inflammatory response 1.30688881638566e-05 0.000281660303791576 1.36468510536398 0.513888888888889 16.2 16 2 malocclusion 0.00166100022699347 0.016761614866719 1.36368825722274 0.513513513513513 16.2 16 2 abnormal neural tube morphology 9.77753500518679e-11 6.75600509038948e-09 1.36058695189442 0.512345679012346 16.2 16 2 arrested B cell differentiation 0.0010040518729459 0.0110025508103653 1.36018713204373 0.51219512195122 16.2 16 2 increased oxygen consumption 2.40901095639738e-06 6.30780500425103e-05 1.3586808340016 0.511627906976744 16.2 16 2 increased circulating creatinine level 2.40901095639738e-06 6.30780500425103e-05 1.3586808340016 0.511627906976744 16.2 16 2 abnormal homeostasis 0.000781653172141568 0.00910099825520812 1.3586808340016 0.511627906976744 16.2 16 2 decreased osteoclast cell number 0.00060898454192657 0.00737152821431797 1.35730842911877 0.511111111111111 16.2 16 2 increased T cell derived lymphoma incidence 0.000370414870541155 0.00494052005614543 1.35489971850809 0.510204081632653 16.2 16 2 decreased circulating creatinine level 0.000370414870541155 0.00494052005614543 1.35489971850809 0.510204081632653 16.2 16 2 decreased circulating total protein level 0.000176495761045175 0.00264477834698719 1.35194357366771 0.509090909090909 16.2 16 2 preweaning lethality, incomplete penetrance 3.8933184865337e-24 2.15213994116724e-21 1.35052693702049 0.508557457212714 16.2 16 2 decreased white adipose tissue amount 4.05681006848355e-05 0.000742008459217121 1.34761966031909 0.507462686567164 16.2 16 2 hemorrhage 2.84848351673792e-14 3.45639158433443e-12 1.34475238444607 0.506382978723404 16.2 16 2 decreased circulating serum albumin level 8.45414886913548e-07 2.51852638466761e-05 1.34121386276559 0.505050505050505 16.2 16 2 ataxia 2.37380286332121e-12 2.18697578611537e-10 1.34094827586207 0.504950495049505 16.2 16 2 abnormal T cell differentiation 6.64799303928099e-07 2.08011102958635e-05 1.34094827586207 0.504950495049505 16.2 16 2 abnormal liver morphology 6.03929083557145e-11 4.29221027242399e-09 1.33521961086496 0.502793296089385 16.2 16 2 abnormal axon morphology 4.75357273156729e-07 1.55389400429742e-05 1.32780172413793 0.5 16.2 16 2 abnormal eating behavior 0.000159675985804627 0.00241800868507073 1.32780172413793 0.5 16.2 16 2 muscular ventricular septal defect 0.000159675985804627 0.00241800868507073 1.32780172413793 0.5 16.2 16 2 increased cell proliferation 0.000334652815257316 0.00451191803768332 1.32780172413793 0.5 16.2 16 2 diluted coat color 0.000334652815257316 0.00451191803768332 1.32780172413793 0.5 16.2 16 2 abnormal interventricular septum morphology 0.000549570157393283 0.00676760280453362 1.32780172413793 0.5 16.2 16 2 gastrointestinal hemorrhage 0.00690775074328805 0.0498781711870218 1.32780172413793 0.5 16.2 16 2 abnormal optic cup morphology 0.00690775074328805 0.0498781711870218 1.32780172413793 0.5 16.2 16 2 heart inflammation 0.011648648878476 0.0764538630216598 1.32780172413793 0.5 16.2 16 2 abnormal lipid homeostasis 3.41287693376025e-08 1.39172645454568e-06 1.32780172413793 0.5 16.2 16 2 abnormal cornea morphology 1.7728275173587e-05 0.000358529142230062 1.32780172413793 0.5 16.2 16 2 atrial septal defect 0.000904876893414152 0.0100936379926803 1.32780172413793 0.5 16.2 16 2 osteoporosis 0.00116241424944463 0.0123591926909207 1.32780172413793 0.5 16.2 16 2 lethality, incomplete penetrance 0.00116241424944463 0.0123591926909207 1.32780172413793 0.5 16.2 16 2 decreased hair follicle number 0.00247746684635714 0.0231680405274939 1.32780172413793 0.5 16.2 16 2 abnormal vertebral body morphology 0.00533413538430553 0.0429406529723624 1.32780172413793 0.5 16.2 16 2 failure of primitive streak formation 0.00533413538430553 0.0429406529723624 1.32780172413793 0.5 16.2 16 2 small superior cervical ganglion 0.00896131270174729 0.061408444478227 1.32780172413793 0.5 16.2 16 2 premature aging 0.00896131270174729 0.061408444478227 1.32780172413793 0.5 16.2 16 2 abnormal renal tubule epithelium morphology 0.00896131270174729 0.061408444478227 1.32780172413793 0.5 16.2 16 2 prolonged QRS complex duration 0.00896131270174729 0.061408444478227 1.32780172413793 0.5 16.2 16 2 abnormal adrenal gland morphology 0.0151767614440892 0.0945504372455322 1.32780172413793 0.5 16.2 16 2 blindness 0.0151767614440892 0.0945504372455322 1.32780172413793 0.5 16.2 16 2 decreased fatty acid level 0.0151767614440892 0.0945504372455322 1.32780172413793 0.5 16.2 16 2 abnormal inner cell mass apoptosis 0.0151767614440892 0.0945504372455322 1.32780172413793 0.5 16.2 16 2 abnormal truncus arteriosus septation 0.0151767614440892 0.0945504372455322 1.32780172413793 0.5 16.2 16 2 increased activated T cell number 0.0198264529515708 0.113760321871362 1.32780172413793 0.5 16.2 16 2 intestinal inflammation 0.0198264529515708 0.113760321871362 1.32780172413793 0.5 16.2 16 2 intracerebral hemorrhage 0.0198264529515708 0.113760321871362 1.32780172413793 0.5 16.2 16 2 abnormal lysosome physiology 0.0198264529515708 0.113760321871362 1.32780172413793 0.5 16.2 16 2 abnormal circulating lipid level 0.0198264529515708 0.113760321871362 1.32780172413793 0.5 16.2 16 2 abnormal sperm midpiece morphology 0.0198264529515708 0.113760321871362 1.32780172413793 0.5 16.2 16 2 abnormal circulating enzyme level 0.0259824253408887 0.134368571799294 1.32780172413793 0.5 16.2 16 2 anencephaly 0.0259824253408887 0.134368571799294 1.32780172413793 0.5 16.2 16 2 decreased circulating VLDL cholesterol level 0.0259824253408887 0.134368571799294 1.32780172413793 0.5 16.2 16 2 abnormal response to tactile stimuli 0.0259824253408887 0.134368571799294 1.32780172413793 0.5 16.2 16 2 abnormal induced retinal neovascularization 0.0259824253408887 0.134368571799294 1.32780172413793 0.5 16.2 16 2 abnormal sperm mitochondrial sheath morphology 0.0259824253408887 0.134368571799294 1.32780172413793 0.5 16.2 16 2 right pulmonary isomerism 0.0341783100759175 0.168187035240049 1.32780172413793 0.5 16.2 16 2 abnormal retinal rod cell morphology 0.0341783100759175 0.168187035240049 1.32780172413793 0.5 16.2 16 2 abnormal thymus cortex morphology 0.0341783100759175 0.168187035240049 1.32780172413793 0.5 16.2 16 2 absent allantois 0.0341783100759175 0.168187035240049 1.32780172413793 0.5 16.2 16 2 increased circulating glycerol level 0.0341783100759175 0.168187035240049 1.32780172413793 0.5 16.2 16 2 abnormal anterior eye segment morphology 0.0341783100759175 0.168187035240049 1.32780172413793 0.5 16.2 16 2 darkened coat color 0.0341783100759175 0.168187035240049 1.32780172413793 0.5 16.2 16 2 primary atelectasis 0.0341783100759175 0.168187035240049 1.32780172413793 0.5 16.2 16 2 absent mandible 0.0451662006812787 0.203903673674557 1.32780172413793 0.5 16.2 16 2 failure of tooth eruption 0.0451662006812787 0.203903673674557 1.32780172413793 0.5 16.2 16 2 vasculature congestion 0.0451662006812787 0.203903673674557 1.32780172413793 0.5 16.2 16 2 abnormal mouth morphology 0.0451662006812787 0.203903673674557 1.32780172413793 0.5 16.2 16 2 poor circulation 0.0451662006812787 0.203903673674557 1.32780172413793 0.5 16.2 16 2 intraventricular hemorrhage 0.0451662006812787 0.203903673674557 1.32780172413793 0.5 16.2 16 2 increased pancreatic beta cell number 0.0451662006812787 0.203903673674557 1.32780172413793 0.5 16.2 16 2 increased cochlear outer hair cell number 0.0451662006812787 0.203903673674557 1.32780172413793 0.5 16.2 16 2 sepsis 0.0451662006812787 0.203903673674557 1.32780172413793 0.5 16.2 16 2 blepharitis 0.0451662006812787 0.203903673674557 1.32780172413793 0.5 16.2 16 2 dystonia 0.0451662006812787 0.203903673674557 1.32780172413793 0.5 16.2 16 2 kidney degeneration 0.0451662006812787 0.203903673674557 1.32780172413793 0.5 16.2 16 2 impaired somite development 0.0451662006812787 0.203903673674557 1.32780172413793 0.5 16.2 16 2 decreased fibroblast apoptosis 0.0451662006812787 0.203903673674557 1.32780172413793 0.5 16.2 16 2 megacephaly 0.0600284903741266 0.249075679408907 1.32780172413793 0.5 16.2 16 2 abnormal kidney blood vessel morphology 0.0600284903741266 0.249075679408907 1.32780172413793 0.5 16.2 16 2 abnormal fluid regulation 0.0600284903741266 0.249075679408907 1.32780172413793 0.5 16.2 16 2 absent olfactory bulb 0.0600284903741266 0.249075679408907 1.32780172413793 0.5 16.2 16 2 split sternum 0.0600284903741266 0.249075679408907 1.32780172413793 0.5 16.2 16 2 abnormal positive T cell selection 0.0600284903741266 0.249075679408907 1.32780172413793 0.5 16.2 16 2 lysosomal protein accumulation 0.0600284903741266 0.249075679408907 1.32780172413793 0.5 16.2 16 2 abnormal viscerocranium morphology 0.0600284903741266 0.249075679408907 1.32780172413793 0.5 16.2 16 2 abnormal glucose tolerance 0.0600284903741266 0.249075679408907 1.32780172413793 0.5 16.2 16 2 multiple persisting craniopharyngeal ducts 0.0600284903741266 0.249075679408907 1.32780172413793 0.5 16.2 16 2 abnormal vitelline vein topology 0.0600284903741266 0.249075679408907 1.32780172413793 0.5 16.2 16 2 mesocardia 0.0803676470169261 0.280188538128386 1.32780172413793 0.5 16.2 16 2 loss of dopaminergic neurons 0.0803676470169261 0.280188538128386 1.32780172413793 0.5 16.2 16 2 decreased left ventricle systolic pressure 0.0803676470169261 0.280188538128386 1.32780172413793 0.5 16.2 16 2 abnormal defecation 0.0803676470169261 0.280188538128386 1.32780172413793 0.5 16.2 16 2 increased hepatocyte proliferation 0.0803676470169261 0.280188538128386 1.32780172413793 0.5 16.2 16 2 vestibular saccular macula degeneration 0.0803676470169261 0.280188538128386 1.32780172413793 0.5 16.2 16 2 stria vascularis degeneration 0.0803676470169261 0.280188538128386 1.32780172413793 0.5 16.2 16 2 abnormal cochlear outer hair cell physiology 0.0803676470169261 0.280188538128386 1.32780172413793 0.5 16.2 16 2 hematuria 0.0803676470169261 0.280188538128386 1.32780172413793 0.5 16.2 16 2 decreased keratinocyte proliferation 0.0803676470169261 0.280188538128386 1.32780172413793 0.5 16.2 16 2 decreased mammary gland epithelial cell proliferation 0.0803676470169261 0.280188538128386 1.32780172413793 0.5 16.2 16 2 enlarged testis 0.108652193002911 0.356795155240582 1.32780172413793 0.5 16.2 16 2 decreased incidence of induced tumors 0.108652193002911 0.356795155240582 1.32780172413793 0.5 16.2 16 2 abnormal primordial germ cell migration 0.108652193002911 0.356795155240582 1.32780172413793 0.5 16.2 16 2 absent seminal vesicle 0.108652193002911 0.356795155240582 1.32780172413793 0.5 16.2 16 2 increased heart rate variability 0.108652193002911 0.356795155240582 1.32780172413793 0.5 16.2 16 2 abnormal reproductive system development 0.108652193002911 0.356795155240582 1.32780172413793 0.5 16.2 16 2 abnormal placental transport 0.108652193002911 0.356795155240582 1.32780172413793 0.5 16.2 16 2 abnormal respiratory conducting tube morphology 0.108652193002911 0.356795155240582 1.32780172413793 0.5 16.2 16 2 absent coat pigmentation 0.108652193002911 0.356795155240582 1.32780172413793 0.5 16.2 16 2 increased platelet aggregation 0.108652193002911 0.356795155240582 1.32780172413793 0.5 16.2 16 2 abnormal vibrissa follicle morphology 0.108652193002911 0.356795155240582 1.32780172413793 0.5 16.2 16 2 increased kidney iron level 0.108652193002911 0.356795155240582 1.32780172413793 0.5 16.2 16 2 decreased trabecular bone connectivity density 0.108652193002911 0.356795155240582 1.32780172413793 0.5 16.2 16 2 increased bone mineral content 6.92165991345551e-07 2.144703806405e-05 1.31562005694401 0.495412844036697 16.2 16 2 increased mean corpuscular hemoglobin 2.30243295942728e-06 6.19167782332472e-05 1.31438958551027 0.494949494949495 16.2 16 2 abnormal lipid level 1.58908685477387e-05 0.000329404462604168 1.31180411300374 0.493975903614458 16.2 16 2 increased neuron apoptosis 2.02501855023513e-05 0.000404597079816056 1.31140911025968 0.493827160493827 16.2 16 2 abnormal visceral yolk sac morphology 2.58118054953558e-05 0.000505565875351948 1.31099410737669 0.493670886075949 16.2 16 2 abnormal myocardium layer morphology 2.58118054953558e-05 0.000505565875351948 1.31099410737669 0.493670886075949 16.2 16 2 delayed bone ossification 4.19706395169386e-05 0.000762058144513757 1.31009770114943 0.493333333333333 16.2 16 2 absent vitelline blood vessels 0.000380491350431613 0.00506134884598202 1.30450695704779 0.491228070175439 16.2 16 2 abnormal mesoderm development 0.000624083300786017 0.00748148053351912 1.30274886141835 0.490566037735849 16.2 16 2 prenatal lethality, incomplete penetrance 6.67341828352154e-16 1.22963910964888e-13 1.30159511116152 0.490131578947368 16.2 16 2 retinal degeneration 5.37346659724732e-06 0.000132341565947056 1.30013918821839 0.489583333333333 16.2 16 2 increased insulin sensitivity 3.12974461235101e-08 1.28681648317738e-06 1.29994574391126 0.48951048951049 16.2 16 2 abnormal developmental patterning 2.9141646160013e-05 0.000561400563259337 1.29541631623213 0.48780487804878 16.2 16 2 Leydig cell hyperplasia 0.00279865266300944 0.0256887398495793 1.29541631623213 0.48780487804878 16.2 16 2 increased tumor growth/size 0.00279865266300944 0.0256887398495793 1.29541631623213 0.48780487804878 16.2 16 2 increased circulating alanine transaminase level 4.73317340862239e-05 0.00085627409846896 1.29375552608311 0.487179487179487 16.2 16 2 abnormal long bone metaphysis morphology 0.0046482172784269 0.0388653461515527 1.29191519105312 0.486486486486487 16.2 16 2 abnormal branching of the mammary ductal tree 0.0046482172784269 0.0388653461515527 1.29191519105312 0.486486486486487 16.2 16 2 increased circulating phosphate level 0.0046482172784269 0.0388653461515527 1.29191519105312 0.486486486486487 16.2 16 2 decreased width of hypertrophic chondrocyte zone 0.0046482172784269 0.0388653461515527 1.29191519105312 0.486486486486487 16.2 16 2 abnormal artery morphology 0.0060009459805769 0.0458661644599547 1.2898645320197 0.485714285714286 16.2 16 2 increased circulating serum albumin level 0.0060009459805769 0.0458661644599547 1.2898645320197 0.485714285714286 16.2 16 2 holoprosencephaly 0.0060009459805769 0.0458661644599547 1.2898645320197 0.485714285714286 16.2 16 2 decreased susceptibility to injury 0.000159904493947391 0.00241800868507073 1.28874873225152 0.485294117647059 16.2 16 2 decreased systemic arterial blood pressure 0.00775780945876393 0.0544359690512702 1.28756530825496 0.484848484848485 16.2 16 2 increased lung adenoma incidence 0.010044179061573 0.0680749895416494 1.28496941045606 0.483870967741935 16.2 16 2 pale kidney 0.010044179061573 0.0680749895416494 1.28496941045606 0.483870967741935 16.2 16 2 abnormal mitochondrial ATP synthesis coupled electron transport 0.010044179061573 0.0680749895416494 1.28496941045606 0.483870967741935 16.2 16 2 small spleen 1.57932167452248e-05 0.000328750013838884 1.28402804092459 0.483516483516484 16.2 16 2 intracranial hemorrhage 0.000426106803114046 0.00538040950632584 1.28354166666667 0.483333333333333 16.2 16 2 increased erythrocyte cell number 0.000426106803114046 0.00538040950632584 1.28354166666667 0.483333333333333 16.2 16 2 increased mortality induced by gamma-irradiation 0.0130265277154415 0.083946859306116 1.28201545778835 0.482758620689655 16.2 16 2 postnatal lethality 8.33731274155838e-09 3.80533310910578e-07 1.27980889073536 0.481927710843373 16.2 16 2 abnormal maxilla morphology 0.000892840180205528 0.0099914954599539 1.27862388250319 0.481481481481481 16.2 16 2 abnormal apoptosis 0.000892840180205528 0.0099914954599539 1.27862388250319 0.481481481481481 16.2 16 2 abnormal trigeminal nerve morphology 0.016927051041951 0.102948751752697 1.27862388250319 0.481481481481481 16.2 16 2 thick interventricular septum 0.016927051041951 0.102948751752697 1.27862388250319 0.481481481481481 16.2 16 2 abnormal somite development 6.72770337558085e-05 0.00115414911356947 1.27737887385421 0.481012658227848 16.2 16 2 abnormal placenta vasculature 0.00114371226087675 0.0122628631419436 1.2767324270557 0.480769230769231 16.2 16 2 decreased kidney weight 0.00114371226087675 0.0122628631419436 1.2767324270557 0.480769230769231 16.2 16 2 abnormal extraembryonic tissue morphology 6.71541271765996e-06 0.00015833733777421 1.27573106828938 0.480392156862745 16.2 16 2 ruffled hair 0.0220441448427728 0.118690065576617 1.27468965517241 0.48 16.2 16 2 abnormal cochlear outer hair cell morphology 0.0220441448427728 0.118690065576617 1.27468965517241 0.48 16.2 16 2 decreased acute inflammation 0.0220441448427728 0.118690065576617 1.27468965517241 0.48 16.2 16 2 decreased total body fat amount 8.01689249642134e-16 1.37531172998952e-13 1.27214536444353 0.479041916167665 16.2 16 2 hydroencephaly 2.25000377452299e-06 6.08356998818037e-05 1.2700712143928 0.478260869565217 16.2 16 2 abnormal spermatogenesis 2.48255405204558e-09 1.23507064089268e-07 1.2700712143928 0.478260869565217 16.2 16 2 conjunctivitis 0.0287815006455486 0.147464434306492 1.2700712143928 0.478260869565217 16.2 16 2 decreased effector memory CD8-positive, alpha-beta T cell number 0.0287815006455486 0.147464434306492 1.2700712143928 0.478260869565217 16.2 16 2 abnormal vertebral artery topology 0.0287815006455486 0.147464434306492 1.2700712143928 0.478260869565217 16.2 16 2 abnormal glucose homeostasis 3.1436394383935e-09 1.53329472607918e-07 1.26943681318681 0.478021978021978 16.2 16 2 perinatal lethality, incomplete penetrance 4.35429945332014e-11 3.28221814852541e-09 1.26904943545926 0.47787610619469 16.2 16 2 abnormal astrocyte morphology 0.0030994455130127 0.02787108799586 1.26744710031348 0.477272727272727 16.2 16 2 muscular atrophy 0.0030994455130127 0.02787108799586 1.26744710031348 0.477272727272727 16.2 16 2 embryonic lethality, incomplete penetrance 0.0030994455130127 0.02787108799586 1.26744710031348 0.477272727272727 16.2 16 2 abnormal bone structure 1.35122624496219e-09 7.30690279205099e-08 1.26588350902269 0.476683937823834 16.2 16 2 abnormal cartilage morphology 0.00398424198384706 0.0343528663251978 1.26457307060755 0.476190476190476 16.2 16 2 disheveled coat 0.00398424198384706 0.0343528663251978 1.26457307060755 0.476190476190476 16.2 16 2 abnormal pancreas morphology 0.00398424198384706 0.0343528663251978 1.26457307060755 0.476190476190476 16.2 16 2 trunk curl 0.0376901791605284 0.182935259827931 1.26457307060755 0.476190476190476 16.2 16 2 increased incidence of induced tumors 0.0376901791605284 0.182935259827931 1.26457307060755 0.476190476190476 16.2 16 2 abnormal bile salt homeostasis 0.0376901791605284 0.182935259827931 1.26457307060755 0.476190476190476 16.2 16 2 complete atrioventricular septal defect 0.0376901791605284 0.182935259827931 1.26457307060755 0.476190476190476 16.2 16 2 perinatal lethality 0.00512619224039982 0.0414006597337485 1.26141163793103 0.475 16.2 16 2 decreased grip strength 1.55716980987447e-10 9.74700354185263e-09 1.26110848685246 0.474885844748858 16.2 16 2 abnormal eye morphology 3.22142612898769e-07 1.11295798553568e-05 1.26093401141156 0.474820143884892 16.2 16 2 increased hemoglobin content 0.000768685325751789 0.00897701759534073 1.26028638223261 0.474576271186441 16.2 16 2 enlarged heart 5.28604477594295e-11 3.86736364122296e-09 1.25912232461356 0.474137931034483 16.2 16 2 kyphoscoliosis 0.0495307833417071 0.221198965103225 1.25791742286751 0.473684210526316 16.2 16 2 irregular coat pigmentation 0.0495307833417071 0.221198965103225 1.25791742286751 0.473684210526316 16.2 16 2 enlarged adrenal glands 0.0495307833417071 0.221198965103225 1.25791742286751 0.473684210526316 16.2 16 2 short vibrissae 0.0495307833417071 0.221198965103225 1.25791742286751 0.473684210526316 16.2 16 2 unresponsive to tactile stimuli 0.0495307833417071 0.221198965103225 1.25791742286751 0.473684210526316 16.2 16 2 abnormal metatarsal bone morphology 0.0495307833417071 0.221198965103225 1.25791742286751 0.473684210526316 16.2 16 2 osteoarthritis 0.0495307833417071 0.221198965103225 1.25791742286751 0.473684210526316 16.2 16 2 absent amnion 0.0495307833417071 0.221198965103225 1.25791742286751 0.473684210526316 16.2 16 2 Leydig cell hypoplasia 0.0495307833417071 0.221198965103225 1.25791742286751 0.473684210526316 16.2 16 2 decreased brain weight 0.00098258251440208 0.010814929223784 1.25791742286751 0.473684210526316 16.2 16 2 kidney cysts 0.000195202194127347 0.00289027058268914 1.25602865796831 0.472972972972973 16.2 16 2 decreased circulating calcium level 0.00125655218713333 0.0131884960569374 1.25537617554859 0.472727272727273 16.2 16 2 abnormal embryo turning 0.00125655218713333 0.0131884960569374 1.25537617554859 0.472727272727273 16.2 16 2 limb grasping 7.7183488832712e-09 3.55544311984021e-07 1.25484558544903 0.472527472527473 16.2 16 2 abnormal neuromuscular synapse morphology 0.000248665944702188 0.00352356837736571 1.25403496168582 0.472222222222222 16.2 16 2 abnormal forebrain development 0.000248665944702188 0.00352356837736571 1.25403496168582 0.472222222222222 16.2 16 2 abnormal placenta development 0.0016076666895292 0.0162563857325361 1.25264313597918 0.471698113207547 16.2 16 2 increased circulating bilirubin level 0.0016076666895292 0.0162563857325361 1.25264313597918 0.471698113207547 16.2 16 2 decreased bone mineral content 8.8313711394782e-10 4.9366372380791e-08 1.25119777851459 0.471153846153846 16.2 16 2 abnormal bone mineralization 2.71518387156677e-06 7.0722721262014e-05 1.25098674836136 0.471074380165289 16.2 16 2 decreased circulating alanine transaminase level 0.000403823572319179 0.00524548896158725 1.24969574036511 0.470588235294118 16.2 16 2 abnormal gastrulation 0.00205792550177837 0.0202335560698565 1.24969574036511 0.470588235294118 16.2 16 2 lung hemorrhage 0.010986621610213 0.0723952880937879 1.24969574036511 0.470588235294118 16.2 16 2 abnormal vision 0.010986621610213 0.0723952880937879 1.24969574036511 0.470588235294118 16.2 16 2 abnormal vagus nerve morphology 0.0653678507808989 0.257079096944642 1.24969574036511 0.470588235294118 16.2 16 2 abnormal melanosome morphology 0.0653678507808989 0.257079096944642 1.24969574036511 0.470588235294118 16.2 16 2 increased circulating magnesium level 0.0653678507808989 0.257079096944642 1.24969574036511 0.470588235294118 16.2 16 2 increased hepatoma incidence 0.0653678507808989 0.257079096944642 1.24969574036511 0.470588235294118 16.2 16 2 abnormal cell cytoskeleton morphology 0.0653678507808989 0.257079096944642 1.24969574036511 0.470588235294118 16.2 16 2 abnormal lung development 8.13082583348589e-05 0.00135287152246128 1.24969574036511 0.470588235294118 16.2 16 2 enlarged liver 2.11125437112344e-05 0.000418647588875439 1.24813362068966 0.47 16.2 16 2 abnormal testis morphology 5.52806368723848e-06 0.000135478408098578 1.24697901049475 0.469565217391304 16.2 16 2 perinatal lethality, complete penetrance 7.62569576045479e-10 4.3111177736662e-08 1.24676218228914 0.469483568075117 16.2 16 2 abnormal long bone hypertrophic chondrocyte zone 0.00263570626678269 0.0246015735032718 1.24650774102745 0.469387755102041 16.2 16 2 abnormal embryo size 7.0068230419949e-06 0.000164428984122286 1.24554851998779 0.469026548672566 16.2 16 2 increased sacral vertebrae number 0.000656477721248161 0.0078509054404077 1.24481411637931 0.46875 16.2 16 2 pancreatic islet hyperplasia 0.0142000999532796 0.0898797675159876 1.24481411637931 0.46875 16.2 16 2 abnormal auditory brainstem response waveform shape 0.0142000999532796 0.0898797675159876 1.24481411637931 0.46875 16.2 16 2 decreased bone trabecula number 0.00337765474356404 0.0301143948910951 1.24304842259721 0.468085106382979 16.2 16 2 abnormal renal glomerulus morphology 1.1257811391627e-05 0.000248922718548198 1.24253005378045 0.467889908256881 16.2 16 2 prenatal lethality 0.000837373514879114 0.00955489274432016 1.24213709677419 0.467741935483871 16.2 16 2 reduced fertility 7.80922770536367e-07 2.37874478604013e-05 1.2418289506326 0.467625899280576 16.2 16 2 abnormal fontanelle morphology 0.0867181388633753 0.299599125587008 1.2392816091954 0.466666666666667 16.2 16 2 abnormal prostate gland morphology 0.0867181388633753 0.299599125587008 1.2392816091954 0.466666666666667 16.2 16 2 audiogenic seizures 0.0867181388633753 0.299599125587008 1.2392816091954 0.466666666666667 16.2 16 2 abnormal seizure response to electrical stimulation 0.0867181388633753 0.299599125587008 1.2392816091954 0.466666666666667 16.2 16 2 joint inflammation 0.0867181388633753 0.299599125587008 1.2392816091954 0.466666666666667 16.2 16 2 abnormal cerebral aqueduct morphology 0.0867181388633753 0.299599125587008 1.2392816091954 0.466666666666667 16.2 16 2 bicuspid aortic valve 0.0867181388633753 0.299599125587008 1.2392816091954 0.466666666666667 16.2 16 2 abnormal branching involved in lung morphogenesis 0.0867181388633753 0.299599125587008 1.2392816091954 0.466666666666667 16.2 16 2 kyphosis 3.31098132659683e-07 1.13309978626194e-05 1.2392816091954 0.466666666666667 16.2 16 2 trabecula carnea hypoplasia 0.00433115126560333 0.0367077982050708 1.2392816091954 0.466666666666667 16.2 16 2 small placenta 0.00433115126560333 0.0367077982050708 1.2392816091954 0.466666666666667 16.2 16 2 lethality at weaning, complete penetrance 0.00433115126560333 0.0367077982050708 1.2392816091954 0.466666666666667 16.2 16 2 decreased bone mineral density 1.37130976202742e-11 1.10036549453006e-09 1.23795047964739 0.466165413533835 16.2 16 2 decreased percent body fat/body weight 0.000344032175252342 0.00461336946598491 1.23685640056684 0.465753424657534 16.2 16 2 abnormal left-right axis patterning 0.00555753647498621 0.0436447568645604 1.23516439454691 0.465116279069767 16.2 16 2 delayed endochondral bone ossification 0.00555753647498621 0.0436447568645604 1.23516439454691 0.465116279069767 16.2 16 2 kidney failure 0.00555753647498621 0.0436447568645604 1.23516439454691 0.465116279069767 16.2 16 2 abnormal enzyme/coenzyme activity 2.24442669266631e-07 7.97573056858206e-06 1.23477103009005 0.464968152866242 16.2 16 2 abnormal ovulation 0.0238306909367942 0.124535385935453 1.23295874384236 0.464285714285714 16.2 16 2 microcephaly 0.000557156241827503 0.00684407976072056 1.23158420789605 0.463768115942029 16.2 16 2 thick ventricular wall 0.00713634005723693 0.0505744897218714 1.23064550042052 0.463414634146341 16.2 16 2 premature death 1.72257627075387e-33 1.22425956385722e-30 1.23064550042052 0.463414634146341 16.2 16 2 abnormal heart morphology 5.2372666040226e-10 2.99487371896695e-08 1.23008471413644 0.463203463203463 16.2 16 2 increased circulating alkaline phosphatase level 1.91901594021414e-07 7.07192911301136e-06 1.22944604086845 0.462962962962963 16.2 16 2 abnormal chondrocyte morphology 0.00222389643894616 0.0215504217603782 1.22944604086845 0.462962962962963 16.2 16 2 abnormal small intestine morphology 0.00222389643894616 0.0215504217603782 1.22944604086845 0.462962962962963 16.2 16 2 impaired limb coordination 0.00222389643894616 0.0215504217603782 1.22944604086845 0.462962962962963 16.2 16 2 cataract 6.4882300760605e-06 0.000155187233790389 1.22903961242519 0.462809917355372 16.2 16 2 small lens 0.00917083883337541 0.0625856285268075 1.22566312997347 0.461538461538462 16.2 16 2 acanthosis 0.00917083883337541 0.0625856285268075 1.22566312997347 0.461538461538462 16.2 16 2 decreased trabecular bone volume 0.00917083883337541 0.0625856285268075 1.22566312997347 0.461538461538462 16.2 16 2 abnormal erythrocyte osmotic lysis 0.0309545699550272 0.154307600727716 1.22566312997347 0.461538461538462 16.2 16 2 short premaxilla 0.115793977928914 0.376450700364617 1.22566312997347 0.461538461538462 16.2 16 2 abnormal mast cell morphology 0.115793977928914 0.376450700364617 1.22566312997347 0.461538461538462 16.2 16 2 abnormal pulmonary alveolus epithelial cell morphology 0.115793977928914 0.376450700364617 1.22566312997347 0.461538461538462 16.2 16 2 abnormal lung interstitium morphology 0.115793977928914 0.376450700364617 1.22566312997347 0.461538461538462 16.2 16 2 abnormal tail bud morphology 0.115793977928914 0.376450700364617 1.22566312997347 0.461538461538462 16.2 16 2 abnormal vestibulocochlear ganglion morphology 0.115793977928914 0.376450700364617 1.22566312997347 0.461538461538462 16.2 16 2 small otic vesicle 0.115793977928914 0.376450700364617 1.22566312997347 0.461538461538462 16.2 16 2 decreased endocochlear potential 0.115793977928914 0.376450700364617 1.22566312997347 0.461538461538462 16.2 16 2 empty decidua capsularis 0.115793977928914 0.376450700364617 1.22566312997347 0.461538461538462 16.2 16 2 abnormal nervous system physiology 1.31347116542001e-05 0.000281660303791576 1.2238868065967 0.460869565217391 16.2 16 2 abnormal skeleton morphology 1.31347116542001e-05 0.000281660303791576 1.2238868065967 0.460869565217391 16.2 16 2 kinked tail 3.96977243172979e-05 0.000736926039099094 1.22366041244084 0.46078431372549 16.2 16 2 gliosis 0.00114985592189734 0.0123022219600845 1.22242063492064 0.46031746031746 16.2 16 2 increased bone mineral density 1.66145113356157e-05 0.000342378882427106 1.22204760451633 0.460176991150442 16.2 16 2 decreased circulating alkaline phosphatase level 0.00363216922749615 0.0318134540612559 1.2215775862069 0.46 16.2 16 2 testicular atrophy 0.00363216922749615 0.0318134540612559 1.2215775862069 0.46 16.2 16 2 abnormal axon extension 0.00363216922749615 0.0318134540612559 1.2215775862069 0.46 16.2 16 2 abnormal circulating protein level 0.00363216922749615 0.0318134540612559 1.2215775862069 0.46 16.2 16 2 decreased oocyte number 0.00363216922749615 0.0318134540612559 1.2215775862069 0.46 16.2 16 2 decreased circulating cholesterol level 5.90900204227801e-08 2.35178281282665e-06 1.21896551724138 0.459016393442623 16.2 16 2 thymus atrophy 0.00464475731461899 0.0388653461515527 1.21715158045977 0.458333333333333 16.2 16 2 abnormal digestive system morphology 0.0402932030467833 0.187344565567988 1.21715158045977 0.458333333333333 16.2 16 2 decreased body height 0.0402932030467833 0.187344565567988 1.21715158045977 0.458333333333333 16.2 16 2 abnormal primitive streak formation 0.0402932030467833 0.187344565567988 1.21715158045977 0.458333333333333 16.2 16 2 abnormal cardiac muscle contractility 0.0402932030467833 0.187344565567988 1.21715158045977 0.458333333333333 16.2 16 2 hypopigmentation 0.0402932030467833 0.187344565567988 1.21715158045977 0.458333333333333 16.2 16 2 microphthalmia 8.33130911929194e-07 2.49688330532996e-05 1.21498196979941 0.457516339869281 16.2 16 2 abnormal kidney morphology 1.49198332563186e-07 5.6661198816935e-06 1.21399014778325 0.457142857142857 16.2 16 2 abnormal dermal layer morphology 0.0151850852983277 0.0945504372455322 1.21399014778325 0.457142857142857 16.2 16 2 ovary cysts 0.0151850852983277 0.0945504372455322 1.21399014778325 0.457142857142857 16.2 16 2 decreased glycogen level 0.0151850852983277 0.0945504372455322 1.21399014778325 0.457142857142857 16.2 16 2 reduced female fertility 1.63603852051725e-09 8.75192649416485e-08 1.21333605826397 0.456896551724138 16.2 16 2 embryonic lethality during organogenesis, incomplete penetrance 2.05970828185372e-09 1.0901115640662e-07 1.21234070464768 0.456521739130435 16.2 16 2 abnormal craniofacial morphology 5.37687285921787e-05 0.000938594472793295 1.2117802142618 0.456310679611651 16.2 16 2 abnormal placenta labyrinth morphology 0.000395822236351696 0.00522338362294346 1.21014840680925 0.455696202531646 16.2 16 2 abnormal vascular development 0.00122642726633719 0.0129268551907362 1.20709247648903 0.454545454545455 16.2 16 2 belly spot 0.019568675365376 0.113466386879657 1.20709247648903 0.454545454545455 16.2 16 2 abnormal locomotor coordination 0.019568675365376 0.113466386879657 1.20709247648903 0.454545454545455 16.2 16 2 abnormal rostral-caudal axis patterning 0.00303001664879019 0.027451142313876 1.20709247648903 0.454545454545455 16.2 16 2 abnormal abdominal fat pad morphology 0.052576617667993 0.223562968289116 1.20709247648903 0.454545454545455 16.2 16 2 abnormal long bone epiphysis morphology 0.052576617667993 0.223562968289116 1.20709247648903 0.454545454545455 16.2 16 2 decreased airway responsiveness 0.052576617667993 0.223562968289116 1.20709247648903 0.454545454545455 16.2 16 2 increased coping response 0.052576617667993 0.223562968289116 1.20709247648903 0.454545454545455 16.2 16 2 abnormal retinal layer morphology 0.052576617667993 0.223562968289116 1.20709247648903 0.454545454545455 16.2 16 2 abnormal limb posture 0.052576617667993 0.223562968289116 1.20709247648903 0.454545454545455 16.2 16 2 abnormal basement membrane morphology 0.052576617667993 0.223562968289116 1.20709247648903 0.454545454545455 16.2 16 2 premature suture closure 0.155925995060155 0.447365527926338 1.20709247648903 0.454545454545455 16.2 16 2 abnormal thrombopoiesis 0.155925995060155 0.447365527926338 1.20709247648903 0.454545454545455 16.2 16 2 abnormal large intestine morphology 0.155925995060155 0.447365527926338 1.20709247648903 0.454545454545455 16.2 16 2 focal hepatic necrosis 0.155925995060155 0.447365527926338 1.20709247648903 0.454545454545455 16.2 16 2 failure of somite differentiation 0.155925995060155 0.447365527926338 1.20709247648903 0.454545454545455 16.2 16 2 rectal hemorrhage 0.155925995060155 0.447365527926338 1.20709247648903 0.454545454545455 16.2 16 2 pulmonary hypertension 0.155925995060155 0.447365527926338 1.20709247648903 0.454545454545455 16.2 16 2 abnormal radial glial cell morphology 0.155925995060155 0.447365527926338 1.20709247648903 0.454545454545455 16.2 16 2 abnormal dorsal-ventral polarity of the somites 0.155925995060155 0.447365527926338 1.20709247648903 0.454545454545455 16.2 16 2 increased circulating triiodothyronine level 0.155925995060155 0.447365527926338 1.20709247648903 0.454545454545455 16.2 16 2 abnormal platelet aggregation 0.155925995060155 0.447365527926338 1.20709247648903 0.454545454545455 16.2 16 2 abnormal superovulation 0.155925995060155 0.447365527926338 1.20709247648903 0.454545454545455 16.2 16 2 abnormal palate development 0.155925995060155 0.447365527926338 1.20709247648903 0.454545454545455 16.2 16 2 increased subcutaneous adipose tissue amount 0.155925995060155 0.447365527926338 1.20709247648903 0.454545454545455 16.2 16 2 decreased core body temperature 0.155925995060155 0.447365527926338 1.20709247648903 0.454545454545455 16.2 16 2 decreased embryonic cilium length 0.155925995060155 0.447365527926338 1.20709247648903 0.454545454545455 16.2 16 2 chylous ascites 0.155925995060155 0.447365527926338 1.20709247648903 0.454545454545455 16.2 16 2 neonatal lethality, incomplete penetrance 3.36696187779952e-10 2.04276040756739e-08 1.20523541114058 0.453846153846154 16.2 16 2 decreased circulating LDL cholesterol level 0.00155865500243523 0.0158251196675822 1.2033203125 0.453125 16.2 16 2 decreased circulating glucose level 1.28655360052915e-10 8.31247293848377e-09 1.19930478309232 0.451612903225806 16.2 16 2 abnormal object recognition memory 0.0252456280991958 0.131377614846756 1.19930478309232 0.451612903225806 16.2 16 2 autoimmune response 0.0252456280991958 0.131377614846756 1.19930478309232 0.451612903225806 16.2 16 2 decreased thymus weight 0.0252456280991958 0.131377614846756 1.19930478309232 0.451612903225806 16.2 16 2 hypoglycemia 0.000173743939104815 0.00261140814817661 1.19930478309232 0.451612903225806 16.2 16 2 sparse hair 0.000420152894791187 0.00535331477749525 1.19826009251472 0.451219512195122 16.2 16 2 increased sensitivity to induced morbidity/mortality 1.79839944371674e-07 6.77805850946272e-06 1.19790807721139 0.451086956521739 16.2 16 2 abnormal cell proliferation 0.0687976217060129 0.263636921914927 1.19502155172414 0.45 16.2 16 2 abnormal hearing physiology 0.0687976217060129 0.263636921914927 1.19502155172414 0.45 16.2 16 2 spleen atrophy 0.0687976217060129 0.263636921914927 1.19502155172414 0.45 16.2 16 2 abnormal optic stalk morphology 0.0687976217060129 0.263636921914927 1.19502155172414 0.45 16.2 16 2 kidney atrophy 0.0687976217060129 0.263636921914927 1.19502155172414 0.45 16.2 16 2 abnormal neuron proliferation 0.0687976217060129 0.263636921914927 1.19502155172414 0.45 16.2 16 2 decreased body weight 8.06857741790762e-42 8.02823453081809e-39 1.19480704417581 0.449919224555735 16.2 16 2 decreased spleen weight 0.0012978933141221 0.013565166465877 1.1930972013993 0.449275362318841 16.2 16 2 polydactyly 0.000145420568362443 0.00222605331570202 1.19231175228712 0.448979591836735 16.2 16 2 increased fluid intake 0.00628176187211525 0.0468618168574828 1.19231175228712 0.448979591836735 16.2 16 2 increased urine protein level 0.000673127734903984 0.00803072057829093 1.19161693191866 0.448717948717949 16.2 16 2 increased blood urea nitrogen level 4.73202830321402e-06 0.000117709204042449 1.19044292508918 0.448275862068966 16.2 16 2 abnormal spermiogenesis 0.00320102138155346 0.0286422326856627 1.19044292508918 0.448275862068966 16.2 16 2 glomerulosclerosis 0.00320102138155346 0.0286422326856627 1.19044292508918 0.448275862068966 16.2 16 2 decreased trophoblast giant cell number 0.0326090735541433 0.162068072859004 1.19044292508918 0.448275862068966 16.2 16 2 polychromatophilia 0.0326090735541433 0.162068072859004 1.19044292508918 0.448275862068966 16.2 16 2 seizures 5.07113179316722e-05 0.000891479882367735 1.1880331215971 0.447368421052632 16.2 16 2 abnormal blood homeostasis 5.07113179316722e-05 0.000891479882367735 1.1880331215971 0.447368421052632 16.2 16 2 increased bone marrow cell number 0.0159996374350734 0.0979067604421772 1.1880331215971 0.447368421052632 16.2 16 2 decreased total retina thickness 0.0159996374350734 0.0979067604421772 1.1880331215971 0.447368421052632 16.2 16 2 abnormal eye development 0.00406941165791031 0.0350265103773422 1.18553725369458 0.446428571428571 16.2 16 2 abnormal angiogenesis 0.00107805975237842 0.0117617264650935 1.1842555917987 0.445945945945946 16.2 16 2 abnormal intestine morphology 0.00107805975237842 0.0117617264650935 1.1842555917987 0.445945945945946 16.2 16 2 increased sensitivity to xenobiotic induced morbidity/mortality 8.04495254811754e-05 0.00134307513177466 1.18295062695925 0.445454545454545 16.2 16 2 increased circulating aspartate transaminase level 0.002646002232543 0.0246514252938229 1.18026819923372 0.444444444444444 16.2 16 2 abnormal ovarian follicle morphology 0.0102257810854528 0.0687476498650373 1.18026819923372 0.444444444444444 16.2 16 2 abnormal uterus morphology 0.0205239133711446 0.113831069143193 1.18026819923372 0.444444444444444 16.2 16 2 abnormal retinal blood vessel morphology 0.0205239133711446 0.113831069143193 1.18026819923372 0.444444444444444 16.2 16 2 rectal prolapse 0.042176585085488 0.194826843825722 1.18026819923372 0.444444444444444 16.2 16 2 increased brain weight 0.042176585085488 0.194826843825722 1.18026819923372 0.444444444444444 16.2 16 2 abnormal fetal cardiomyocyte proliferation 0.042176585085488 0.194826843825722 1.18026819923372 0.444444444444444 16.2 16 2 abnormal skin appearance 0.042176585085488 0.194826843825722 1.18026819923372 0.444444444444444 16.2 16 2 abnormal bone trabecula morphology 0.042176585085488 0.194826843825722 1.18026819923372 0.444444444444444 16.2 16 2 abnormal mitral valve morphology 0.0903194833448842 0.310746493527524 1.18026819923372 0.444444444444444 16.2 16 2 increased susceptibility to autoimmune disorder 0.0903194833448842 0.310746493527524 1.18026819923372 0.444444444444444 16.2 16 2 abnormal glycogen homeostasis 0.0903194833448842 0.310746493527524 1.18026819923372 0.444444444444444 16.2 16 2 increased gastrointestinal tumor incidence 0.0903194833448842 0.310746493527524 1.18026819923372 0.444444444444444 16.2 16 2 abnormal motor coordination/ balance 0.000192976207656665 0.00286584069579674 1.18026819923372 0.444444444444444 16.2 16 2 increased circulating cholesterol level 9.83630409559794e-07 2.8955983950059e-05 1.1769151645768 0.443181818181818 16.2 16 2 hunched posture 0.000893711654206932 0.0099914954599539 1.17653317328677 0.443037974683544 16.2 16 2 abnormal organ of Corti morphology 0.0130515597880396 0.0839993660355721 1.17340617481957 0.441860465116279 16.2 16 2 increased circulating triglyceride level 1.03467653530034e-05 0.000230830303278886 1.17212841854935 0.441379310344828 16.2 16 2 postnatal growth retardation 2.30279858529105e-19 6.73907233048412e-17 1.17158975659229 0.441176470588235 16.2 16 2 abnormal endoderm development 0.0263439809615573 0.135814824128236 1.17158975659229 0.441176470588235 16.2 16 2 increased width of hypertrophic chondrocyte zone 0.0263439809615573 0.135814824128236 1.17158975659229 0.441176470588235 16.2 16 2 decreased cytotoxic T cell cytolysis 0.0263439809615573 0.135814824128236 1.17158975659229 0.441176470588235 16.2 16 2 hydronephrosis 0.000739741498984998 0.00872088615509565 1.16973009031199 0.44047619047619 16.2 16 2 kidney inflammation 0.00836358466431599 0.0577098941816533 1.16846551724138 0.44 16.2 16 2 abnormal thyroid gland morphology 0.054631748778506 0.231313149083462 1.16846551724138 0.44 16.2 16 2 abnormal cholesterol homeostasis 0.0166621643293572 0.101586112179598 1.16587468460892 0.439024390243902 16.2 16 2 lethality at weaning, incomplete penetrance 0.0166621643293572 0.101586112179598 1.16587468460892 0.439024390243902 16.2 16 2 seminiferous tubule degeneration 0.00179880957107184 0.0177914067914163 1.16410014170997 0.438356164383562 16.2 16 2 abnormal muscle physiology 0.000611541224749061 0.00738450872118101 1.16369139868268 0.438202247191011 16.2 16 2 decreased circulating HDL cholesterol level 4.83787638260269e-05 0.000863662899334486 1.16182650862069 0.4375 16.2 16 2 abnormal coat/hair pigmentation 0.000138879859389942 0.00213249166810173 1.16182650862069 0.4375 16.2 16 2 kidney cortex cysts 0.0338365944349083 0.167833556643737 1.16182650862069 0.4375 16.2 16 2 increased circulating follicle stimulating hormone level 0.0338365944349083 0.167833556643737 1.16182650862069 0.4375 16.2 16 2 abnormal bone marrow cell number 0.119036313005006 0.382068165935422 1.16182650862069 0.4375 16.2 16 2 abnormal extraembryonic endoderm formation 0.119036313005006 0.382068165935422 1.16182650862069 0.4375 16.2 16 2 abnormal meiosis 0.119036313005006 0.382068165935422 1.16182650862069 0.4375 16.2 16 2 abnormal olfaction 0.119036313005006 0.382068165935422 1.16182650862069 0.4375 16.2 16 2 impaired muscle relaxation 0.119036313005006 0.382068165935422 1.16182650862069 0.4375 16.2 16 2 abnormal pulmonary elastic fiber morphology 0.119036313005006 0.382068165935422 1.16182650862069 0.4375 16.2 16 2 small pancreas 0.119036313005006 0.382068165935422 1.16182650862069 0.4375 16.2 16 2 abnormal thoracic cage shape 0.119036313005006 0.382068165935422 1.16182650862069 0.4375 16.2 16 2 decreased adipocyte glucose uptake 0.119036313005006 0.382068165935422 1.16182650862069 0.4375 16.2 16 2 decreased body size 7.49089779740711e-24 3.72672165421004e-21 1.16141053063694 0.43734335839599 16.2 16 2 abnormal trabecular bone morphology 9.17191668410605e-05 0.00149607493453861 1.16043175891046 0.436974789915966 16.2 16 2 abnormal lung morphology 9.17191668410605e-05 0.00149607493453861 1.16043175891046 0.436974789915966 16.2 16 2 abnormal ovary morphology 0.00227012040611949 0.0217189404239317 1.1594888295289 0.436619718309859 16.2 16 2 abnormal joint morphology 0.00683330852042903 0.0498446699217584 1.15880877742947 0.436363636363636 16.2 16 2 abnormal cardiovascular system physiology 4.01225994083113e-05 0.000742008459217121 1.15808270676692 0.43609022556391 16.2 16 2 abnormal circulating hormone level 0.0212764363545672 0.117742236778612 1.15757073386384 0.435897435897436 16.2 16 2 cleft palate 5.02394703493203e-05 0.000889471049778891 1.15549157673072 0.435114503816794 16.2 16 2 hypoactivity 9.85841872354923e-12 8.17427219160957e-10 1.15522272020488 0.435013262599469 16.2 16 2 abnormal brain morphology 7.74907987403347e-06 0.000180993767010876 1.15461019490255 0.434782608695652 16.2 16 2 perimembraneous ventricular septal defect 0.00286414104365032 0.0262414395804058 1.15461019490255 0.434782608695652 16.2 16 2 delayed wound healing 0.0135207628085279 0.0865711647006771 1.15461019490255 0.434782608695652 16.2 16 2 abnormal cranial nerve morphology 0.0708805538391043 0.263636921914927 1.15461019490255 0.434782608695652 16.2 16 2 abnormal postnatal growth 0.0708805538391043 0.263636921914927 1.15461019490255 0.434782608695652 16.2 16 2 pancreas inflammation 0.0708805538391043 0.263636921914927 1.15461019490255 0.434782608695652 16.2 16 2 abnormal Wolffian duct morphology 0.0708805538391043 0.263636921914927 1.15461019490255 0.434782608695652 16.2 16 2 decreased epididymis weight 0.0708805538391043 0.263636921914927 1.15461019490255 0.434782608695652 16.2 16 2 abnormal hepatocyte physiology 0.0708805538391043 0.263636921914927 1.15461019490255 0.434782608695652 16.2 16 2 decreased body length 7.14268601307098e-09 3.32101522570356e-07 1.15334602315631 0.434306569343066 16.2 16 2 weight loss 3.41736790513603e-06 8.71866939900089e-05 1.15329064039409 0.434285714285714 16.2 16 2 short tail 0.00121773972840665 0.0128625374709619 1.15182800166182 0.433734939759036 16.2 16 2 impaired coordination 9.98720978677798e-11 6.80635187523568e-09 1.15127317121786 0.433526011560694 16.2 16 2 arrested T cell differentiation 0.0434897798979597 0.200334865733657 1.15076149425287 0.433333333333333 16.2 16 2 thin ventricular wall 0.000797168499398839 0.00924455311074412 1.15076149425287 0.433333333333333 16.2 16 2 abnormal myocardial fiber morphology 0.000522958655899687 0.00649229178087081 1.14984891574831 0.43298969072165 16.2 16 2 decreased compact bone thickness 0.00361250288203771 0.0318134540612559 1.14944029850746 0.432835820895522 16.2 16 2 maternal effect 0.00361250288203771 0.0318134540612559 1.14944029850746 0.432835820895522 16.2 16 2 decreased cardiac muscle contractility 0.000343700251213159 0.00461336946598491 1.14905918435013 0.432692307692308 16.2 16 2 small seminiferous tubules 0.00234795229007637 0.022221795963327 1.14836905871389 0.432432432432432 16.2 16 2 increased liver weight 0.00100096474162796 0.0109929350763777 1.14673785266458 0.431818181818182 16.2 16 2 abnormal gluconeogenesis 0.010971940063168 0.0723952880937879 1.14555442866802 0.431372549019608 16.2 16 2 abnormal thrombosis 0.010971940063168 0.0723952880937879 1.14555442866802 0.431372549019608 16.2 16 2 abnormal enzyme/coenzyme level 0.00705059612002691 0.0503246288692263 1.1446566587396 0.431034482758621 16.2 16 2 no abnormal phenotype detected 5.04114348311652e-47 6.26992220712617e-44 1.14183295239988 0.429971181556196 16.2 16 2 postnatal lethality, incomplete penetrance 5.82241659434551e-16 1.11409702141804e-13 1.14078739679456 0.429577464788732 16.2 16 2 cardiac hypertrophy 0.000675500248934369 0.00803974578576193 1.1381157635468 0.428571428571429 16.2 16 2 abnormal retina morphology 9.15331311321939e-07 2.71057932965872e-05 1.1381157635468 0.428571428571429 16.2 16 2 increased circulating HDL cholesterol level 0.000443575968441328 0.00558681124809015 1.1381157635468 0.428571428571429 16.2 16 2 abnormal seminal vesicle morphology 0.00890623116731807 0.0613691136529188 1.1381157635468 0.428571428571429 16.2 16 2 skin edema 0.021853602205369 0.118225688965279 1.1381157635468 0.428571428571429 16.2 16 2 rib bifurcation 0.0559360056970085 0.235831888425947 1.1381157635468 0.428571428571429 16.2 16 2 reddish skin 0.0559360056970085 0.235831888425947 1.1381157635468 0.428571428571429 16.2 16 2 hypoxia 0.0559360056970085 0.235831888425947 1.1381157635468 0.428571428571429 16.2 16 2 increased triglyceride level 0.0559360056970085 0.235831888425947 1.1381157635468 0.428571428571429 16.2 16 2 abnormal hematopoietic system physiology 0.0921282036151261 0.314765176718265 1.1381157635468 0.428571428571429 16.2 16 2 left pulmonary isomerism 0.0921282036151261 0.314765176718265 1.1381157635468 0.428571428571429 16.2 16 2 decreased cochlear outer hair cell number 0.0921282036151261 0.314765176718265 1.1381157635468 0.428571428571429 16.2 16 2 increased muscle cell glucose uptake 0.0921282036151261 0.314765176718265 1.1381157635468 0.428571428571429 16.2 16 2 absent atrioventricular cushions 0.157618093595005 0.448085723220085 1.1381157635468 0.428571428571429 16.2 16 2 translucent skin 0.157618093595005 0.448085723220085 1.1381157635468 0.428571428571429 16.2 16 2 abnormal placing response 0.157618093595005 0.448085723220085 1.1381157635468 0.428571428571429 16.2 16 2 absent otoliths 0.157618093595005 0.448085723220085 1.1381157635468 0.428571428571429 16.2 16 2 intestinal obstruction 0.157618093595005 0.448085723220085 1.1381157635468 0.428571428571429 16.2 16 2 abnormal voluntary movement 0.157618093595005 0.448085723220085 1.1381157635468 0.428571428571429 16.2 16 2 abnormal pancreas development 0.157618093595005 0.448085723220085 1.1381157635468 0.428571428571429 16.2 16 2 pulmonary alveolar hemorrhage 0.157618093595005 0.448085723220085 1.1381157635468 0.428571428571429 16.2 16 2 decreased compact bone area 0.157618093595005 0.448085723220085 1.1381157635468 0.428571428571429 16.2 16 2 abnormal renal tubule epithelial cell primary cilium morphology 0.157618093595005 0.448085723220085 1.1381157635468 0.428571428571429 16.2 16 2 abnormal intestinal goblet cell morphology 0.0347131527089796 0.170145748499679 1.1381157635468 0.428571428571429 16.2 16 2 abnormal midbrain development 0.0347131527089796 0.170145748499679 1.1381157635468 0.428571428571429 16.2 16 2 decreased circulating thyroxine level 0.0347131527089796 0.170145748499679 1.1381157635468 0.428571428571429 16.2 16 2 decreased bone mineralization 0.0347131527089796 0.170145748499679 1.1381157635468 0.428571428571429 16.2 16 2 abnormal behavior 1.94837501522681e-08 8.28475700919093e-07 1.1367511163483 0.428057553956835 16.2 16 2 azoospermia 2.00158592866636e-05 0.000401527822383674 1.13572977662112 0.427672955974843 16.2 16 2 small testis 2.42055005583714e-08 1.0119526493941e-06 1.13536669165417 0.427536231884058 16.2 16 2 increased startle reflex 0.00129112344047892 0.0135228191923844 1.13385315769082 0.426966292134831 16.2 16 2 abnormal neurocranium morphology 0.00303479965279031 0.027451142313876 1.13305747126437 0.426666666666667 16.2 16 2 abnormal long bone morphology 0.00723260490222768 0.0511110928815095 1.13189655172414 0.426229508196721 16.2 16 2 abnormal pulmonary alveolus morphology 0.000693314312036967 0.00821247310091407 1.13060344827586 0.425742574257426 16.2 16 2 hepatic necrosis 0.0176000293299002 0.106262313005162 1.13004402054292 0.425531914893617 16.2 16 2 abnormal skin pigmentation 0.0277780798634116 0.142912044798834 1.12863146551724 0.425 16.2 16 2 abnormal pancreatic beta cell morphology 0.0277780798634116 0.142912044798834 1.12863146551724 0.425 16.2 16 2 abnormal fertility/fecundity 0.00380865173574066 0.0332147957765445 1.12772201228153 0.424657534246575 16.2 16 2 abnormal neuron morphology 0.00086613938335636 0.00979328052772248 1.12661964472309 0.424242424242424 16.2 16 2 dextrocardia 0.0443497979598269 0.203730604663101 1.12661964472309 0.424242424242424 16.2 16 2 abnormal ovarian folliculogenesis 0.0443497979598269 0.203730604663101 1.12661964472309 0.424242424242424 16.2 16 2 cachexia 0.000709420991431523 0.00838330031442239 1.12352453580902 0.423076923076923 16.2 16 2 abnormal brain wave pattern 0.0141942095947318 0.0898797675159876 1.12352453580902 0.423076923076923 16.2 16 2 abnormal nasal bone morphology 0.0719950132490572 0.263636921914927 1.12352453580902 0.423076923076923 16.2 16 2 abnormal xiphoid process morphology 0.0719950132490572 0.263636921914927 1.12352453580902 0.423076923076923 16.2 16 2 abnormal Mullerian duct morphology 0.0719950132490572 0.263636921914927 1.12352453580902 0.423076923076923 16.2 16 2 increased rib number 0.00310363472355908 0.02787108799586 1.12352453580902 0.423076923076923 16.2 16 2 increased circulating free fatty acid level 0.00477720665507189 0.0398100554589324 1.12208596406022 0.422535211267606 16.2 16 2 decreased liver weight 0.00477720665507189 0.0398100554589324 1.12208596406022 0.422535211267606 16.2 16 2 impaired balance 0.000884711613439657 0.00995800967615903 1.11951910074375 0.42156862745098 16.2 16 2 decreased birth weight 0.00134954466650746 0.0140754396559217 1.11814882032668 0.421052631578947 16.2 16 2 abnormal frontal bone morphology 0.0353011927228508 0.172518107854797 1.11814882032668 0.421052631578947 16.2 16 2 abnormal compact bone morphology 0.0353011927228508 0.172518107854797 1.11814882032668 0.421052631578947 16.2 16 2 abnormal digestive system development 0.119983992438104 0.382151320345433 1.11814882032668 0.421052631578947 16.2 16 2 increased liver adenoma incidence 0.119983992438104 0.382151320345433 1.11814882032668 0.421052631578947 16.2 16 2 abnormal optic vesicle formation 0.119983992438104 0.382151320345433 1.11814882032668 0.421052631578947 16.2 16 2 abnormal cochlear inner hair cell morphology 0.119983992438104 0.382151320345433 1.11814882032668 0.421052631578947 16.2 16 2 decreased circulating magnesium level 0.119983992438104 0.382151320345433 1.11814882032668 0.421052631578947 16.2 16 2 decreased liver glycogen level 0.119983992438104 0.382151320345433 1.11814882032668 0.421052631578947 16.2 16 2 abnormal gait 1.57421171463475e-08 6.93071086752912e-07 1.11724416917755 0.420711974110032 16.2 16 2 abnormal blood vessel morphology 9.20914456115506e-05 0.0014972383722793 1.11718489892985 0.420689655172414 16.2 16 2 decreased respiratory quotient 0.0179062383829369 0.107773937819699 1.11535344827586 0.42 16.2 16 2 reduced male fertility 1.65480722131472e-06 4.62509321687683e-05 1.11137589245025 0.418502202643172 16.2 16 2 improved glucose tolerance 8.29394716138894e-06 0.000188412726611461 1.11101776917664 0.418367346938776 16.2 16 2 increased circulating calcium level 0.0144176033381329 0.0910248434101662 1.11052507836991 0.418181818181818 16.2 16 2 abnormal head morphology 0.0144176033381329 0.0910248434101662 1.11052507836991 0.418181818181818 16.2 16 2 abnormal seminiferous tubule morphology 0.000116326497931289 0.00180287952401297 1.10953294756731 0.417808219178082 16.2 16 2 respiratory failure 9.54238545140737e-05 0.00152647484311099 1.10796700159854 0.417218543046358 16.2 16 2 arrest of spermatogenesis 0.00321127819121217 0.0286824219053511 1.10650143678161 0.416666666666667 16.2 16 2 curly tail 0.0225757052899502 0.120379564648984 1.10650143678161 0.416666666666667 16.2 16 2 ocular hypertelorism 0.092728661547905 0.314765176718265 1.10650143678161 0.416666666666667 16.2 16 2 small lymph nodes 0.092728661547905 0.314765176718265 1.10650143678161 0.416666666666667 16.2 16 2 prolonged QT interval 0.092728661547905 0.314765176718265 1.10650143678161 0.416666666666667 16.2 16 2 abnormal mineral level 0.209896243662461 0.523780657692343 1.10650143678161 0.416666666666667 16.2 16 2 impaired embryo implantation 0.209896243662461 0.523780657692343 1.10650143678161 0.416666666666667 16.2 16 2 increased litter size 0.209896243662461 0.523780657692343 1.10650143678161 0.416666666666667 16.2 16 2 abnormal corticospinal tract morphology 0.209896243662461 0.523780657692343 1.10650143678161 0.416666666666667 16.2 16 2 abnormal AMPA-mediated synaptic currents 0.209896243662461 0.523780657692343 1.10650143678161 0.416666666666667 16.2 16 2 dilated bile duct 0.209896243662461 0.523780657692343 1.10650143678161 0.416666666666667 16.2 16 2 abnormal nucleotide metabolism 0.209896243662461 0.523780657692343 1.10650143678161 0.416666666666667 16.2 16 2 pale placenta 0.209896243662461 0.523780657692343 1.10650143678161 0.416666666666667 16.2 16 2 small parietal bone 0.209896243662461 0.523780657692343 1.10650143678161 0.416666666666667 16.2 16 2 hemoperitoneum 0.209896243662461 0.523780657692343 1.10650143678161 0.416666666666667 16.2 16 2 decreased renal glomerular filtration rate 0.209896243662461 0.523780657692343 1.10650143678161 0.416666666666667 16.2 16 2 decreased prostaglandin level 0.209896243662461 0.523780657692343 1.10650143678161 0.416666666666667 16.2 16 2 abnormal aorta elastic tissue morphology 0.209896243662461 0.523780657692343 1.10650143678161 0.416666666666667 16.2 16 2 male infertility 3.39009835770051e-12 3.01173916599287e-10 1.10342171111263 0.415506958250497 16.2 16 2 abnormal pancreatic islet morphology 0.0181219689363474 0.107972210129734 1.10232595966168 0.415094339622642 16.2 16 2 cochlear ganglion degeneration 0.0145768655580202 0.0917973495584186 1.09887039239001 0.413793103448276 16.2 16 2 abnormal embryonic neuroepithelium morphology 0.0145768655580202 0.0917973495584186 1.09887039239001 0.413793103448276 16.2 16 2 focal hair loss 0.0724020754449131 0.263636921914927 1.09887039239001 0.413793103448276 16.2 16 2 short sternum 0.0724020754449131 0.263636921914927 1.09887039239001 0.413793103448276 16.2 16 2 abnormal cued conditioning behavior 0.0227602472067753 0.120968555654598 1.09348377281947 0.411764705882353 16.2 16 2 abnormal dendritic spine morphology 0.0227602472067753 0.120968555654598 1.09348377281947 0.411764705882353 16.2 16 2 overexpanded pulmonary alveoli 0.0569538698586155 0.238707247301274 1.09348377281947 0.411764705882353 16.2 16 2 abnormal nervous system development 0.0569538698586155 0.238707247301274 1.09348377281947 0.411764705882353 16.2 16 2 decreased regulatory T cell number 0.0569538698586155 0.238707247301274 1.09348377281947 0.411764705882353 16.2 16 2 abnormal skin physiology 0.0569538698586155 0.238707247301274 1.09348377281947 0.411764705882353 16.2 16 2 distended urinary bladder 0.156604236561881 0.447762113158251 1.09348377281947 0.411764705882353 16.2 16 2 abnormal tarsal bone morphology 0.156604236561881 0.447762113158251 1.09348377281947 0.411764705882353 16.2 16 2 abnormal survival 0.156604236561881 0.447762113158251 1.09348377281947 0.411764705882353 16.2 16 2 abnormal electroretinogram waveform feature 0.156604236561881 0.447762113158251 1.09348377281947 0.411764705882353 16.2 16 2 delayed heart development 0.156604236561881 0.447762113158251 1.09348377281947 0.411764705882353 16.2 16 2 decreased body fat mass 0.156604236561881 0.447762113158251 1.09348377281947 0.411764705882353 16.2 16 2 impaired glucose tolerance 1.82461814073368e-06 5.01517969621551e-05 1.09222399888765 0.411290322580645 16.2 16 2 decreased startle reflex 0.000947546818016447 0.0105130136364593 1.0894783377542 0.41025641025641 16.2 16 2 hypertension 0.0358070431798634 0.174476042918531 1.08638322884013 0.409090909090909 16.2 16 2 abnormal amino acid level 0.0358070431798634 0.174476042918531 1.08638322884013 0.409090909090909 16.2 16 2 abnormal enterocyte morphology 0.119510070809295 0.382109641565709 1.08638322884013 0.409090909090909 16.2 16 2 aphakia 0.119510070809295 0.382109641565709 1.08638322884013 0.409090909090909 16.2 16 2 abnormal blood-brain barrier function 0.119510070809295 0.382109641565709 1.08638322884013 0.409090909090909 16.2 16 2 cleft upper lip 0.119510070809295 0.382109641565709 1.08638322884013 0.409090909090909 16.2 16 2 rough coat 0.119510070809295 0.382109641565709 1.08638322884013 0.409090909090909 16.2 16 2 abnormal skeletal muscle fiber morphology 0.00953976846174729 0.0650141754756066 1.08468309859155 0.408450704225352 16.2 16 2 abnormal craniofacial development 0.0285601063029392 0.146783604191242 1.08391977480647 0.408163265306122 16.2 16 2 short snout 0.00177679934631798 0.0176438657643352 1.08191251596424 0.407407407407407 16.2 16 2 increased exploration in new environment 0.00623586935241155 0.0468079547023723 1.08191251596424 0.407407407407407 16.2 16 2 decreased heart weight 0.00623586935241155 0.0468079547023723 1.08191251596424 0.407407407407407 16.2 16 2 abnormal mandible morphology 0.02284920504521 0.120968555654598 1.08191251596424 0.407407407407407 16.2 16 2 abnormal osteoblast physiology 0.02284920504521 0.120968555654598 1.08191251596424 0.407407407407407 16.2 16 2 abnormal heart valve morphology 0.0924951826115111 0.314765176718265 1.08191251596424 0.407407407407407 16.2 16 2 abnormal type II pneumocyte morphology 0.0924951826115111 0.314765176718265 1.08191251596424 0.407407407407407 16.2 16 2 small ovary 0.00409511277682331 0.0351868498526701 1.07975085259568 0.406593406593407 16.2 16 2 abnormal lens morphology 0.000782960251905342 0.00910099825520812 1.07883890086207 0.40625 16.2 16 2 decreased eosinophil cell number 0.0147324315812235 0.0926597308679986 1.07883890086207 0.40625 16.2 16 2 scoliosis 0.072286307812111 0.263636921914927 1.07883890086207 0.40625 16.2 16 2 polydipsia 0.072286307812111 0.263636921914927 1.07883890086207 0.40625 16.2 16 2 abnormal spongiotrophoblast layer morphology 0.072286307812111 0.263636921914927 1.07883890086207 0.40625 16.2 16 2 abnormal sternum morphology 0.0118652638545821 0.0776256718732608 1.07763618190905 0.405797101449275 16.2 16 2 abnormal hair follicle development 0.0568988474754014 0.238707247301274 1.07659599254427 0.405405405405405 16.2 16 2 abnormal calcium ion homeostasis 0.0568988474754014 0.238707247301274 1.07659599254427 0.405405405405405 16.2 16 2 spina bifida 0.0450346641564052 0.203903673674557 1.07488711001642 0.404761904761905 16.2 16 2 decreased rib number 0.00506651644380604 0.0414006597337485 1.07417667570709 0.404494382022472 16.2 16 2 increased circulating glucose level 0.000523298292287276 0.00649229178087081 1.07354181951577 0.404255319148936 16.2 16 2 increased respiratory quotient 0.0358011927570263 0.174476042918531 1.07354181951577 0.404255319148936 16.2 16 2 abnormal circulating amino acid level 0.0228563703146376 0.120968555654598 1.0715592861464 0.403508771929825 16.2 16 2 cochlear outer hair cell degeneration 0.011873997245337 0.0776256718732608 1.06961805555556 0.402777777777778 16.2 16 2 short limbs 0.00626192916940776 0.0468618168574828 1.06834621482362 0.402298850574713 16.2 16 2 female infertility 3.53077426677698e-06 8.94297218099945e-05 1.06823146227638 0.402255639097744 16.2 16 2 increased body weight 2.11217175492935e-05 0.000418647588875439 1.06698352832512 0.401785714285714 16.2 16 2 insulin resistance 0.000968054880025132 0.0106786541643571 1.06626502089864 0.401515151515151 16.2 16 2 abnormal long bone epiphyseal plate morphology 0.022793661852847 0.120968555654598 1.06224137931034 0.4 16.2 16 2 mandible hypoplasia 0.118126603394171 0.381362655344582 1.06224137931034 0.4 16.2 16 2 abnormal feces composition 0.118126603394171 0.381362655344582 1.06224137931034 0.4 16.2 16 2 abnormal vertebrae development 0.118126603394171 0.381362655344582 1.06224137931034 0.4 16.2 16 2 abnormal energy expenditure 0.118126603394171 0.381362655344582 1.06224137931034 0.4 16.2 16 2 small gonad 0.154108239592831 0.446788165486209 1.06224137931034 0.4 16.2 16 2 brain inflammation 0.154108239592831 0.446788165486209 1.06224137931034 0.4 16.2 16 2 abnormal hair texture 0.154108239592831 0.446788165486209 1.06224137931034 0.4 16.2 16 2 decreased muscle cell glucose uptake 0.154108239592831 0.446788165486209 1.06224137931034 0.4 16.2 16 2 decreased chondrocyte number 0.204884730082757 0.523780657692343 1.06224137931034 0.4 16.2 16 2 vagina atresia 0.204884730082757 0.523780657692343 1.06224137931034 0.4 16.2 16 2 hyperpigmentation 0.204884730082757 0.523780657692343 1.06224137931034 0.4 16.2 16 2 absent egg cylinders 0.204884730082757 0.523780657692343 1.06224137931034 0.4 16.2 16 2 abnormal cricoid cartilage morphology 0.204884730082757 0.523780657692343 1.06224137931034 0.4 16.2 16 2 arthritis 0.204884730082757 0.523780657692343 1.06224137931034 0.4 16.2 16 2 abnormal glial cell morphology 0.204884730082757 0.523780657692343 1.06224137931034 0.4 16.2 16 2 abnormal aorta wall morphology 0.204884730082757 0.523780657692343 1.06224137931034 0.4 16.2 16 2 cardiac fibrosis 0.00773091983366113 0.0543673066033744 1.06224137931034 0.4 16.2 16 2 irregular heartbeat 0.0448253192810965 0.203903673674557 1.06224137931034 0.4 16.2 16 2 albuminuria 0.0448253192810965 0.203903673674557 1.06224137931034 0.4 16.2 16 2 cardiomyopathy 0.0448253192810965 0.203903673674557 1.06224137931034 0.4 16.2 16 2 impaired behavioral response to xenobiotic 0.0717810146250394 0.263636921914927 1.06224137931034 0.4 16.2 16 2 impaired adaptive thermogenesis 0.0717810146250394 0.263636921914927 1.06224137931034 0.4 16.2 16 2 decreased litter size 3.54123722544099e-06 8.94297218099945e-05 1.05846116087864 0.398576512455516 16.2 16 2 lethargy 0.00623792441561263 0.0468079547023723 1.05653040415276 0.397849462365591 16.2 16 2 absent gastric milk in neonates 0.0118087604559293 0.0774026130016444 1.05543213969938 0.397435897435897 16.2 16 2 skin lesions 0.0226713822101067 0.120760306740129 1.05381089217296 0.396825396825397 16.2 16 2 hyperactivity 1.81205089620644e-07 6.77816030723838e-06 1.05222023422251 0.39622641509434 16.2 16 2 abnormal phalanx morphology 0.0444661673044211 0.203903673674557 1.05117636494253 0.395833333333333 16.2 16 2 abnormal cranium morphology 0.00144667070096911 0.0148090262084801 1.05035061760165 0.395522388059701 16.2 16 2 decreased oxygen consumption 0.0560477816171551 0.236103059733571 1.04988973536488 0.395348837209302 16.2 16 2 hyporesponsive to tactile stimuli 0.0709842744879345 0.263636921914927 1.04826451905626 0.394736842105263 16.2 16 2 neonatal lethality, complete penetrance 1.13009914631014e-08 5.06508401161528e-07 1.04826451905626 0.394736842105263 16.2 16 2 increased or absent threshold for auditory brainstem response 5.18054905650157e-06 0.00012822503261739 1.04753907648252 0.394463667820069 16.2 16 2 corneal opacity 0.0180806944248754 0.107855461347428 1.04728023312288 0.394366197183099 16.2 16 2 increased osteoblast cell number 0.090445039216096 0.310748667196186 1.04614681295716 0.393939393939394 16.2 16 2 cardiovascular system phenotype 0.090445039216096 0.310748667196186 1.04614681295716 0.393939393939394 16.2 16 2 short mandible 0.035077655868761 0.171763127900675 1.04327278325123 0.392857142857143 16.2 16 2 abnormal stria vascularis morphology 0.116151120615012 0.376450700364617 1.04327278325123 0.392857142857143 16.2 16 2 shortened head 0.116151120615012 0.376450700364617 1.04327278325123 0.392857142857143 16.2 16 2 abnormal somite shape 0.116151120615012 0.376450700364617 1.04327278325123 0.392857142857143 16.2 16 2 failure of blastocyst to hatch from the zona pellucida 0.116151120615012 0.376450700364617 1.04327278325123 0.392857142857143 16.2 16 2 corneal vascularization 0.116151120615012 0.376450700364617 1.04327278325123 0.392857142857143 16.2 16 2 abnormal forelimb morphology 0.0553566330587869 0.23418303526145 1.03914917541229 0.391304347826087 16.2 16 2 fragile skeleton 0.150771903147275 0.438649250384616 1.03914917541229 0.391304347826087 16.2 16 2 hypotension 0.150771903147275 0.438649250384616 1.03914917541229 0.391304347826087 16.2 16 2 abnormal corneal stroma morphology 0.150771903147275 0.438649250384616 1.03914917541229 0.391304347826087 16.2 16 2 abnormal lens development 0.150771903147275 0.438649250384616 1.03914917541229 0.391304347826087 16.2 16 2 abnormal palatal shelf fusion at midline 0.150771903147275 0.438649250384616 1.03914917541229 0.391304347826087 16.2 16 2 abnormal basicranium morphology 0.150771903147275 0.438649250384616 1.03914917541229 0.391304347826087 16.2 16 2 abnormal retinal pigmentation 0.0115498934397193 0.0759058386560152 1.03782203725723 0.390804597701149 16.2 16 2 cyanosis 0.00027569696013977 0.00380997882415376 1.03734509698276 0.390625 16.2 16 2 decreased heart rate 0.00749288520032626 0.0528753246406002 1.03568534482759 0.39 16.2 16 2 decreased insulin secretion 0.0114308075239493 0.0752225759677883 1.0327346743295 0.388888888888889 16.2 16 2 abnormal heart left ventricle morphology 0.0220304108118544 0.118690065576617 1.0327346743295 0.388888888888889 16.2 16 2 renal hypoplasia 0.0889199997816979 0.306780165682349 1.0327346743295 0.388888888888889 16.2 16 2 absent spleen 0.198785443154515 0.517778837535975 1.0327346743295 0.388888888888889 16.2 16 2 abnormal phrenic nerve morphology 0.198785443154515 0.517778837535975 1.0327346743295 0.388888888888889 16.2 16 2 thick dermal layer 0.198785443154515 0.517778837535975 1.0327346743295 0.388888888888889 16.2 16 2 abnormal thyroid cartilage morphology 0.198785443154515 0.517778837535975 1.0327346743295 0.388888888888889 16.2 16 2 acidosis 0.198785443154515 0.517778837535975 1.0327346743295 0.388888888888889 16.2 16 2 increased circulating renin level 0.198785443154515 0.517778837535975 1.0327346743295 0.388888888888889 16.2 16 2 absent ureter 0.198785443154515 0.517778837535975 1.0327346743295 0.388888888888889 16.2 16 2 long tibia 0.198785443154515 0.517778837535975 1.0327346743295 0.388888888888889 16.2 16 2 jerky movement 0.198785443154515 0.517778837535975 1.0327346743295 0.388888888888889 16.2 16 2 decreased pulmonary respiratory rate 0.198785443154515 0.517778837535975 1.0327346743295 0.388888888888889 16.2 16 2 atrioventricular block 0.198785443154515 0.517778837535975 1.0327346743295 0.388888888888889 16.2 16 2 postnatal lethality, complete penetrance 5.41084322969743e-07 1.71458248839138e-05 1.03197025192067 0.38860103626943 16.2 16 2 organ of Corti degeneration 0.0545400059386928 0.231121405063881 1.02972378606615 0.387755102040816 16.2 16 2 abnormal postnatal growth/weight/body size 0.11378904065252 0.3726797085229 1.02797552836485 0.387096774193548 16.2 16 2 abnormal intestine physiology 0.11378904065252 0.3726797085229 1.02797552836485 0.387096774193548 16.2 16 2 hyperglycemia 0.0139695738457955 0.0887594251377175 1.02602860501567 0.386363636363636 16.2 16 2 abnormal craniofacial bone morphology 0.0427596067884958 0.197153886721749 1.02496975196612 0.385964912280702 16.2 16 2 abnormal skin condition 0.0536267079008597 0.227444903501089 1.02138594164456 0.384615384615385 16.2 16 2 abnormal hair growth 0.0536267079008597 0.227444903501089 1.02138594164456 0.384615384615385 16.2 16 2 thick skin 0.146958847234867 0.434766466520193 1.02138594164456 0.384615384615385 16.2 16 2 absent myocardial trabeculae 0.268710159745927 0.557299106998435 1.02138594164456 0.384615384615385 16.2 16 2 abnormal renal/urinary system morphology 0.268710159745927 0.557299106998435 1.02138594164456 0.384615384615385 16.2 16 2 hyperalgesia 0.268710159745927 0.557299106998435 1.02138594164456 0.384615384615385 16.2 16 2 decreased cardiac stroke volume 0.268710159745927 0.557299106998435 1.02138594164456 0.384615384615385 16.2 16 2 abnormal heart looping 0.0871884804309885 0.301015052147236 1.02138594164456 0.384615384615385 16.2 16 2 reduced long term potentiation 0.00714678584616162 0.0505764716709161 1.01956203817734 0.383928571428571 16.2 16 2 epidermal hyperplasia 0.042047558968146 0.194826843825722 1.01798132183908 0.383333333333333 16.2 16 2 pulmonary hypoplasia 0.0674944925564312 0.263636921914927 1.01703961848863 0.382978723404255 16.2 16 2 abnormal skeleton development 0.0211106816035614 0.11695505676806 1.01634206045126 0.382716049382716 16.2 16 2 abnormal retinal photoreceptor morphology 0.111177667865965 0.364607051834657 1.01537778904665 0.382352941176471 16.2 16 2 abnormal contextual conditioning behavior 0.052639778786299 0.223640392367069 1.01395768025078 0.381818181818182 16.2 16 2 increased heart weight 0.00364496815855991 0.0318694491895177 1.01256822128504 0.381294964028777 16.2 16 2 abnormal muscle morphology 0.0853138573564415 0.29660128605751 1.01165845648604 0.380952380952381 16.2 16 2 abnormal scapula morphology 0.192249800194495 0.504452930362666 1.01165845648604 0.380952380952381 16.2 16 2 abnormal salivary gland morphology 0.192249800194495 0.504452930362666 1.01165845648604 0.380952380952381 16.2 16 2 abnormal associative learning 0.192249800194495 0.504452930362666 1.01165845648604 0.380952380952381 16.2 16 2 abnormal embryonic/fetal subventricular zone morphology 0.192249800194495 0.504452930362666 1.01165845648604 0.380952380952381 16.2 16 2 abnormal clavicle morphology 0.192249800194495 0.504452930362666 1.01165845648604 0.380952380952381 16.2 16 2 vascular ring 0.192249800194495 0.504452930362666 1.01165845648604 0.380952380952381 16.2 16 2 increased bone ossification 0.192249800194495 0.504452930362666 1.01165845648604 0.380952380952381 16.2 16 2 abnormal spatial learning 0.00190111352840666 0.0187659519917125 1.01010683308652 0.380368098159509 16.2 16 2 increased circulating chloride level 0.0661099768879171 0.259792365732534 1.00912931034483 0.38 16.2 16 2 aphagia 0.142886648218962 0.42874612478247 1.00729785969084 0.379310344827586 16.2 16 2 absent long term depression 0.142886648218962 0.42874612478247 1.00729785969084 0.379310344827586 16.2 16 2 enlarged epididymis 0.142886648218962 0.42874612478247 1.00729785969084 0.379310344827586 16.2 16 2 increased retinal apoptosis 0.142886648218962 0.42874612478247 1.00729785969084 0.379310344827586 16.2 16 2 alopecia 0.0162250893838868 0.0991643976472198 1.00633393829401 0.378947368421053 16.2 16 2 abnormal motor capabilities/coordination/movement 0.00539182644977348 0.0433349540995526 1.00591039707419 0.378787878787879 16.2 16 2 increased brown adipose tissue amount 0.108411135968139 0.356795155240582 1.00482292637465 0.378378378378378 16.2 16 2 abnormal vocalization 0.108411135968139 0.356795155240582 1.00482292637465 0.378378378378378 16.2 16 2 abnormal breathing pattern 0.108411135968139 0.356795155240582 1.00482292637465 0.378378378378378 16.2 16 2 abnormal respiratory electron transport chain 0.108411135968139 0.356795155240582 1.00482292637465 0.378378378378378 16.2 16 2 abnormal metabolism 0.0833431190732128 0.290155365562795 1.00322796934866 0.377777777777778 16.2 16 2 abnormal coat/ hair morphology 0.06466410403495 0.256925307667227 1.00211450878334 0.377358490566038 16.2 16 2 hyperkeratosis 0.0396722179915773 0.185716148378836 1.00066216891554 0.376811594202899 16.2 16 2 decreased caudal vertebrae number 0.0494054989146429 0.221198965103225 0.995851293103448 0.375 16.2 16 2 abnormal tooth morphology 0.0494054989146429 0.221198965103225 0.995851293103448 0.375 16.2 16 2 abnormal crypts of Lieberkuhn morphology 0.138690680356765 0.417414479597644 0.995851293103448 0.375 16.2 16 2 abnormal lymphatic vessel morphology 0.138690680356765 0.417414479597644 0.995851293103448 0.375 16.2 16 2 bradykinesia 0.138690680356765 0.417414479597644 0.995851293103448 0.375 16.2 16 2 abnormal hair follicle orientation 0.256393780329408 0.557299106998435 0.995851293103448 0.375 16.2 16 2 mixed cellular infiltration to dermis 0.256393780329408 0.557299106998435 0.995851293103448 0.375 16.2 16 2 disorganized retinal layers 0.256393780329408 0.557299106998435 0.995851293103448 0.375 16.2 16 2 small epididymis 0.256393780329408 0.557299106998435 0.995851293103448 0.375 16.2 16 2 increased thymus weight 0.256393780329408 0.557299106998435 0.995851293103448 0.375 16.2 16 2 decreased circulating triiodothyronine level 0.256393780329408 0.557299106998435 0.995851293103448 0.375 16.2 16 2 impaired behavioral response to addictive substance 0.256393780329408 0.557299106998435 0.995851293103448 0.375 16.2 16 2 abnormal pulmonary alveolus wall morphology 0.256393780329408 0.557299106998435 0.995851293103448 0.375 16.2 16 2 embryonic lethality between somite formation and embryo turning, incomplete penetrance 0.256393780329408 0.557299106998435 0.995851293103448 0.375 16.2 16 2 teratozoospermia 0.0242647945548544 0.126670884481008 0.995851293103448 0.375 16.2 16 2 abnormal posture 0.0306447798790327 0.152916529486648 0.995851293103448 0.375 16.2 16 2 oligodactyly 0.0813114877076378 0.283280568169116 0.995851293103448 0.375 16.2 16 2 increased susceptibility to weight loss 0.105555255655898 0.351027671716639 0.995851293103448 0.375 16.2 16 2 curly vibrissae 0.185597848106897 0.488803226221182 0.995851293103448 0.375 16.2 16 2 abnormal startle reflex 0.185597848106897 0.488803226221182 0.995851293103448 0.375 16.2 16 2 abnormal vasodilation 0.185597848106897 0.488803226221182 0.995851293103448 0.375 16.2 16 2 abnormal lung saccule morphology 0.185597848106897 0.488803226221182 0.995851293103448 0.375 16.2 16 2 increased anxiety-related response 0.00614634063551953 0.0463303706995601 0.993463160506078 0.37410071942446 16.2 16 2 abnormal limb morphology 0.0379780771533997 0.184152956957274 0.991425287356322 0.373333333333333 16.2 16 2 cochlear inner hair cell degeneration 0.0792455904380064 0.278422890133532 0.98934246112238 0.372549019607843 16.2 16 2 abnormal male reproductive system morphology 0.102656717053796 0.3416168343429 0.98813151563753 0.372093023255814 16.2 16 2 abnormal blood circulation 0.102656717053796 0.3416168343429 0.98813151563753 0.372093023255814 16.2 16 2 abnormal action potential 0.0471391419569289 0.212617616714163 0.986366995073891 0.371428571428571 16.2 16 2 abnormal cochlea morphology 0.0771656817177265 0.271498774077574 0.983556832694764 0.37037037037037 16.2 16 2 abnormal long bone epiphyseal plate proliferative zone 0.0771656817177265 0.271498774077574 0.983556832694764 0.37037037037037 16.2 16 2 wrinkled skin 0.178996297013312 0.485193955941496 0.983556832694764 0.37037037037037 16.2 16 2 thin epidermis 0.178996297013312 0.485193955941496 0.983556832694764 0.37037037037037 16.2 16 2 abnormal brain commissure morphology 0.178996297013312 0.485193955941496 0.983556832694764 0.37037037037037 16.2 16 2 decreased bone ossification 0.178996297013312 0.485193955941496 0.983556832694764 0.37037037037037 16.2 16 2 abnormal retinal outer nuclear layer morphology 0.130243471831592 0.393658124156846 0.978380217785844 0.368421052631579 16.2 16 2 impaired branching involved in ureteric bud morphogenesis 0.130243471831592 0.393658124156846 0.978380217785844 0.368421052631579 16.2 16 2 abnormal nail morphology 0.244752956072422 0.557299106998435 0.978380217785844 0.368421052631579 16.2 16 2 shiny skin 0.244752956072422 0.557299106998435 0.978380217785844 0.368421052631579 16.2 16 2 stereotypic behavior 0.244752956072422 0.557299106998435 0.978380217785844 0.368421052631579 16.2 16 2 decreased grooming behavior 0.244752956072422 0.557299106998435 0.978380217785844 0.368421052631579 16.2 16 2 delayed sexual maturation 0.244752956072422 0.557299106998435 0.978380217785844 0.368421052631579 16.2 16 2 abnormal nasal septum morphology 0.244752956072422 0.557299106998435 0.978380217785844 0.368421052631579 16.2 16 2 abnormal neural crest cell migration 0.244752956072422 0.557299106998435 0.978380217785844 0.368421052631579 16.2 16 2 oliguria 0.244752956072422 0.557299106998435 0.978380217785844 0.368421052631579 16.2 16 2 abnormal sternebra morphology 0.244752956072422 0.557299106998435 0.978380217785844 0.368421052631579 16.2 16 2 abnormal behavioral response to xenobiotic 0.244752956072422 0.557299106998435 0.978380217785844 0.368421052631579 16.2 16 2 thin interventricular septum 0.244752956072422 0.557299106998435 0.978380217785844 0.368421052631579 16.2 16 2 abnormal lactation 0.172534374526166 0.485193955941496 0.973721264367816 0.366666666666667 16.2 16 2 abnormal response/metabolism to endogenous compounds 0.0426013377837916 0.196606359438185 0.971562237174096 0.365853658536585 16.2 16 2 abnormal mammary gland development 0.12608555537812 0.393043350595912 0.971562237174096 0.365853658536585 16.2 16 2 scaly skin 0.12608555537812 0.393043350595912 0.971562237174096 0.365853658536585 16.2 16 2 short humerus 0.12608555537812 0.393043350595912 0.971562237174096 0.365853658536585 16.2 16 2 palatal shelves fail to meet at midline 0.12608555537812 0.393043350595912 0.971562237174096 0.365853658536585 16.2 16 2 increased total body fat amount 0.012295790399109 0.0802776341674109 0.971078872876994 0.365671641791045 16.2 16 2 abnormal snout morphology 0.0939958561412119 0.314765176718265 0.970316644562334 0.365384615384615 16.2 16 2 eyelids open at birth 0.0939958561412119 0.314765176718265 0.970316644562334 0.365384615384615 16.2 16 2 respiratory distress 0.00564664261685168 0.0439625148964587 0.967069463823002 0.364161849710983 16.2 16 2 abnormal aorta morphology 0.166259618151433 0.470769265966636 0.965673981191223 0.363636363636364 16.2 16 2 absent vibrissae 0.166259618151433 0.470769265966636 0.965673981191223 0.363636363636364 16.2 16 2 deafness 0.0311720083500969 0.155235977519252 0.965673981191222 0.363636363636364 16.2 16 2 abnormal suckling behavior 0.0403955467763705 0.1876450468837 0.965673981191222 0.363636363636364 16.2 16 2 omphalocele 0.122008012362904 0.387852946648848 0.965673981191222 0.363636363636364 16.2 16 2 renal interstitial fibrosis 0.122008012362904 0.387852946648848 0.965673981191222 0.363636363636364 16.2 16 2 cochlear hair cell degeneration 0.122008012362904 0.387852946648848 0.965673981191222 0.363636363636364 16.2 16 2 abnormal facial nerve morphology 0.233815359843182 0.557299106998435 0.965673981191222 0.363636363636364 16.2 16 2 increased body size 0.233815359843182 0.557299106998435 0.965673981191222 0.363636363636364 16.2 16 2 abnormal tail movements 0.233815359843182 0.557299106998435 0.965673981191222 0.363636363636364 16.2 16 2 testis hypoplasia 0.233815359843182 0.557299106998435 0.965673981191222 0.363636363636364 16.2 16 2 abnormal cochlear sensory epithelium morphology 0.233815359843182 0.557299106998435 0.965673981191222 0.363636363636364 16.2 16 2 parakeratosis 0.233815359843182 0.557299106998435 0.965673981191222 0.363636363636364 16.2 16 2 abnormal occipital bone morphology 0.233815359843182 0.557299106998435 0.965673981191222 0.363636363636364 16.2 16 2 failure of palatal shelf elevation 0.233815359843182 0.557299106998435 0.965673981191222 0.363636363636364 16.2 16 2 abnormal cerebral cortex pyramidal cell morphology 0.233815359843182 0.557299106998435 0.965673981191222 0.363636363636364 16.2 16 2 increased thermal nociceptive threshold 0.0393173039076019 0.185716148378836 0.963021030693444 0.362637362637363 16.2 16 2 abnormal tibia morphology 0.118026538841373 0.381362655344582 0.960537417461482 0.361702127659574 16.2 16 2 increased systemic arterial blood pressure 0.118026538841373 0.381362655344582 0.960537417461482 0.361702127659574 16.2 16 2 abnormal digit morphology 0.0650454804702512 0.256925307667227 0.958967911877395 0.361111111111111 16.2 16 2 impaired wound healing 0.160196100255003 0.454117150295522 0.958967911877395 0.361111111111111 16.2 16 2 abnormal limb bone morphology 0.160196100255003 0.454117150295522 0.958967911877395 0.361111111111111 16.2 16 2 increased body length 0.114150980277652 0.37361916242192 0.95601724137931 0.36 16.2 16 2 diaphragmatic hernia 0.223550423257805 0.549216471954361 0.95601724137931 0.36 16.2 16 2 increased liver glycogen level 0.223550423257805 0.549216471954361 0.95601724137931 0.36 16.2 16 2 abnormal heart ventricle morphology 0.0612890793741537 0.254094308238679 0.953293545534925 0.358974358974359 16.2 16 2 increased vascular permeability 0.15435426701593 0.447240814446273 0.953293545534925 0.358974358974359 16.2 16 2 enlarged kidney 0.110387129377064 0.362253277474205 0.952008783344177 0.358490566037736 16.2 16 2 impaired righting response 0.0443345080663697 0.203730604663101 0.950426497277677 0.357894736842105 16.2 16 2 abnormal reproductive system morphology 0.148736498723497 0.434766466520193 0.948429802955665 0.357142857142857 16.2 16 2 abnormal respiration 0.213910283901256 0.526833496241954 0.948429802955665 0.357142857142857 16.2 16 2 abnormal retinal inner nuclear layer morphology 0.213910283901256 0.526833496241954 0.948429802955665 0.357142857142857 16.2 16 2 abnormal hormone level 0.213910283901256 0.526833496241954 0.948429802955665 0.357142857142857 16.2 16 2 midline facial cleft 0.330427974274218 0.620331763024239 0.948429802955665 0.357142857142857 16.2 16 2 irregularly shaped pupil 0.330427974274218 0.620331763024239 0.948429802955665 0.357142857142857 16.2 16 2 abnormal sagittal suture morphology 0.330427974274218 0.620331763024239 0.948429802955665 0.357142857142857 16.2 16 2 abnormal decidualization 0.330427974274218 0.620331763024239 0.948429802955665 0.357142857142857 16.2 16 2 skeletal muscle necrosis 0.330427974274218 0.620331763024239 0.948429802955665 0.357142857142857 16.2 16 2 abnormal iris pigmentation 0.330427974274218 0.620331763024239 0.948429802955665 0.357142857142857 16.2 16 2 increased circulating growth hormone level 0.330427974274218 0.620331763024239 0.948429802955665 0.357142857142857 16.2 16 2 spina bifida occulta 0.330427974274218 0.620331763024239 0.948429802955665 0.357142857142857 16.2 16 2 sternebra fusion 0.330427974274218 0.620331763024239 0.948429802955665 0.357142857142857 16.2 16 2 increased lung compliance 0.330427974274218 0.620331763024239 0.948429802955665 0.357142857142857 16.2 16 2 abnormal axial skeleton morphology 0.0732226398740025 0.263636921914927 0.943438067150635 0.355263157894737 16.2 16 2 infertility 0.0394266732848721 0.185716148378836 0.943111504995166 0.355140186915888 16.2 16 2 abnormal cranial ganglia morphology 0.204844308156672 0.523780657692343 0.942310901001112 0.354838709677419 16.2 16 2 absent mature ovarian follicles 0.204844308156672 0.523780657692343 0.942310901001112 0.354838709677419 16.2 16 2 abnormal eyelid morphology 0.204844308156672 0.523780657692343 0.942310901001112 0.354838709677419 16.2 16 2 abnormal nose morphology 0.204844308156672 0.523780657692343 0.942310901001112 0.354838709677419 16.2 16 2 abnormal intestinal epithelium morphology 0.138160599140518 0.416575139832774 0.940526221264368 0.354166666666667 16.2 16 2 abnormal kidney physiology 0.138160599140518 0.416575139832774 0.940526221264368 0.354166666666667 16.2 16 2 abnormal response to novel object 0.133190283826549 0.40232037767886 0.937271805273834 0.352941176470588 16.2 16 2 short maxilla 0.196304318307143 0.51427803242656 0.937271805273834 0.352941176470588 16.2 16 2 thin skin 0.196304318307143 0.51427803242656 0.937271805273834 0.352941176470588 16.2 16 2 increased incidence of corneal inflammation 0.310824440566242 0.587296464799488 0.937271805273834 0.352941176470588 16.2 16 2 abnormal testis development 0.310824440566242 0.587296464799488 0.937271805273834 0.352941176470588 16.2 16 2 decreased growth hormone level 0.310824440566242 0.587296464799488 0.937271805273834 0.352941176470588 16.2 16 2 pancytopenia 0.310824440566242 0.587296464799488 0.937271805273834 0.352941176470588 16.2 16 2 abnormal tendon morphology 0.310824440566242 0.587296464799488 0.937271805273834 0.352941176470588 16.2 16 2 common atrium 0.310824440566242 0.587296464799488 0.937271805273834 0.352941176470588 16.2 16 2 short femur 0.0644700962106847 0.256925307667227 0.935496669278997 0.352272727272727 16.2 16 2 polyphagia 0.128421629534991 0.393043350595912 0.934378991060026 0.351851851851852 16.2 16 2 abnormal facial morphology 0.123846439982824 0.392943902368972 0.931790683605565 0.350877192982456 16.2 16 2 polyuria 0.0843524041592656 0.293463783700941 0.931185624720107 0.350649350649351 16.2 16 2 abnormal incisor morphology 0.119456416180803 0.382109641565709 0.929461206896552 0.35 16.2 16 2 decreased circulating phosphate level 0.180630657748254 0.485193955941496 0.929461206896552 0.35 16.2 16 2 impaired ovarian folliculogenesis 0.180630657748254 0.485193955941496 0.929461206896552 0.35 16.2 16 2 abnormal vascular regression 0.293561649561432 0.572397776191652 0.929461206896552 0.35 16.2 16 2 waved hair 0.293561649561432 0.572397776191652 0.929461206896552 0.35 16.2 16 2 increased urine glucose level 0.293561649561432 0.572397776191652 0.929461206896552 0.35 16.2 16 2 abnormal trachea morphology 0.293561649561432 0.572397776191652 0.929461206896552 0.35 16.2 16 2 abnormal hyoid bone morphology 0.293561649561432 0.572397776191652 0.929461206896552 0.35 16.2 16 2 decreased skin tensile strength 0.293561649561432 0.572397776191652 0.929461206896552 0.35 16.2 16 2 abnormal lens epithelium morphology 0.293561649561432 0.572397776191652 0.929461206896552 0.35 16.2 16 2 abnormal heart right ventricle morphology 0.293561649561432 0.572397776191652 0.929461206896552 0.35 16.2 16 2 abnormal postnatal subventricular zone morphology 0.293561649561432 0.572397776191652 0.929461206896552 0.35 16.2 16 2 abnormal coat appearance 0.107316317101593 0.356407661936199 0.923688155922039 0.347826086956522 16.2 16 2 abnormal food intake 0.107316317101593 0.356407661936199 0.923688155922039 0.347826086956522 16.2 16 2 abnormal inner ear morphology 0.166589101732681 0.47116587897674 0.923688155922039 0.347826086956522 16.2 16 2 abnormal sleep pattern 0.166589101732681 0.47116587897674 0.923688155922039 0.347826086956522 16.2 16 2 abnormal blood vessel physiology 0.278105203414332 0.563803336180236 0.923688155922039 0.347826086956522 16.2 16 2 abnormal pulmonary artery morphology 0.278105203414332 0.563803336180236 0.923688155922039 0.347826086956522 16.2 16 2 abnormal circulating insulin level 0.278105203414332 0.563803336180236 0.923688155922039 0.347826086956522 16.2 16 2 abnormal nasal cavity morphology 0.278105203414332 0.563803336180236 0.923688155922039 0.347826086956522 16.2 16 2 abnormal cochlear ganglion morphology 0.278105203414332 0.563803336180236 0.923688155922039 0.347826086956522 16.2 16 2 abnormal sacral vertebrae morphology 0.278105203414332 0.563803336180236 0.923688155922039 0.347826086956522 16.2 16 2 increased susceptibility to age related obesity 0.278105203414332 0.563803336180236 0.923688155922039 0.347826086956522 16.2 16 2 absent kidney 0.160103551059703 0.454117150295522 0.921331808585503 0.346938775510204 16.2 16 2 abnormal epidermis stratum corneum morphology 0.160103551059703 0.454117150295522 0.921331808585503 0.346938775510204 16.2 16 2 increased susceptibility to injury 0.153940274954081 0.446788165486209 0.919247347480106 0.346153846153846 16.2 16 2 decreased body temperature 0.153940274954081 0.446788165486209 0.919247347480106 0.346153846153846 16.2 16 2 abnormal stomach morphology 0.264098904681714 0.557299106998435 0.919247347480106 0.346153846153846 16.2 16 2 abnormal kidney cortex morphology 0.264098904681714 0.557299106998435 0.919247347480106 0.346153846153846 16.2 16 2 abnormal ureter morphology 0.264098904681714 0.557299106998435 0.919247347480106 0.346153846153846 16.2 16 2 abnormal ocular fundus morphology 0.264098904681714 0.557299106998435 0.919247347480106 0.346153846153846 16.2 16 2 abnormal tectorial membrane morphology 0.264098904681714 0.557299106998435 0.919247347480106 0.346153846153846 16.2 16 2 abnormal excitatory postsynaptic currents 0.0965623996337365 0.321982532290777 0.919247347480106 0.346153846153846 16.2 16 2 neonatal lethality 0.239496208432813 0.557299106998435 0.912863685344828 0.34375 16.2 16 2 abnormal lumbar vertebrae morphology 0.239496208432813 0.557299106998435 0.912863685344828 0.34375 16.2 16 2 abnormal depression-related behavior 0.239496208432813 0.557299106998435 0.912863685344828 0.34375 16.2 16 2 abnormal urine homeostasis 0.0785107724001785 0.276036107908755 0.912863685344828 0.34375 16.2 16 2 rib fusion 0.127239982870222 0.393043350595912 0.911625064333505 0.343283582089552 16.2 16 2 thick epidermis 0.122605188389391 0.389253868689994 0.910492610837438 0.342857142857143 16.2 16 2 dehydration 0.122605188389391 0.389253868689994 0.910492610837438 0.342857142857143 16.2 16 2 persistence of hyaloid vascular system 0.218407754298029 0.537112495122439 0.908495916515426 0.342105263157895 16.2 16 2 abnormal reproductive system physiology 0.218407754298029 0.537112495122439 0.908495916515426 0.342105263157895 16.2 16 2 decreased threshold for auditory brainstem response 0.218407754298029 0.537112495122439 0.908495916515426 0.342105263157895 16.2 16 2 decreased anxiety-related response 0.0580617527751732 0.243145808128356 0.906791421362489 0.341463414634146 16.2 16 2 small kidney 0.0986724249249174 0.328797933021744 0.905319357366771 0.340909090909091 16.2 16 2 abnormal circadian rhythm 0.200015587607059 0.520438048297655 0.905319357366771 0.340909090909091 16.2 16 2 abnormal photoreceptor outer segment morphology 0.200015587607059 0.520438048297655 0.905319357366771 0.340909090909091 16.2 16 2 abnormal rib morphology 0.0509131377558984 0.222115272491606 0.904872286079183 0.340740740740741 16.2 16 2 cleft secondary palate 0.0919450207294391 0.314765176718265 0.904035216434336 0.340425531914894 16.2 16 2 abnormal hindlimb morphology 0.183776087523183 0.48528982772178 0.902905172413793 0.34 16.2 16 2 abnormal digestive system physiology 0.183776087523183 0.48528982772178 0.902905172413793 0.34 16.2 16 2 atelectasis 0.13915013666893 0.418544093064042 0.897668771248179 0.338028169014085 16.2 16 2 distended abdomen 0.2090689893715 0.523780657692343 0.885201149425287 0.333333333333333 16.2 16 2 abnormal cervical vertebrae morphology 0.2090689893715 0.523780657692343 0.885201149425287 0.333333333333333 16.2 16 2 increased kidney weight 0.2090689893715 0.523780657692343 0.885201149425287 0.333333333333333 16.2 16 2 impaired swimming 0.169862868116731 0.480152141409511 0.885201149425287 0.333333333333333 16.2 16 2 abnormal kidney development 0.184231961000049 0.48623554693647 0.885201149425287 0.333333333333333 16.2 16 2 abnormal iris morphology 0.250434497939078 0.557299106998435 0.885201149425287 0.333333333333333 16.2 16 2 reduced long term depression 0.262760278551257 0.557299106998435 0.885201149425287 0.333333333333333 16.2 16 2 head tilt 0.262760278551257 0.557299106998435 0.885201149425287 0.333333333333333 16.2 16 2 narrow eye opening 0.262760278551257 0.557299106998435 0.885201149425287 0.333333333333333 16.2 16 2 abnormal tooth development 0.276114503573503 0.561368882418544 0.885201149425287 0.333333333333333 16.2 16 2 abnormal epidermis stratum basale morphology 0.276114503573503 0.561368882418544 0.885201149425287 0.333333333333333 16.2 16 2 dilated heart atrium 0.276114503573503 0.561368882418544 0.885201149425287 0.333333333333333 16.2 16 2 single kidney 0.276114503573503 0.561368882418544 0.885201149425287 0.333333333333333 16.2 16 2 head tossing 0.276114503573503 0.561368882418544 0.885201149425287 0.333333333333333 16.2 16 2 abnormal heart tube morphology 0.290669529916927 0.572397776191652 0.885201149425287 0.333333333333333 16.2 16 2 delayed eyelid opening 0.290669529916927 0.572397776191652 0.885201149425287 0.333333333333333 16.2 16 2 decreased susceptibility to pharmacologically induced seizures 0.306650208515915 0.580732694087049 0.885201149425287 0.333333333333333 16.2 16 2 abnormal palate morphology 0.306650208515915 0.580732694087049 0.885201149425287 0.333333333333333 16.2 16 2 hypoalgesia 0.3442175742449 0.644274805067109 0.885201149425287 0.333333333333333 16.2 16 2 dry skin 0.3442175742449 0.644274805067109 0.885201149425287 0.333333333333333 16.2 16 2 lowered ear position 0.366843939272105 0.679720148185745 0.885201149425287 0.333333333333333 16.2 16 2 abnormal heart shape 0.366843939272105 0.679720148185745 0.885201149425287 0.333333333333333 16.2 16 2 underdeveloped hair follicles 0.366843939272105 0.679720148185745 0.885201149425287 0.333333333333333 16.2 16 2 abnormal metanephric mesenchyme morphology 0.366843939272105 0.679720148185745 0.885201149425287 0.333333333333333 16.2 16 2 placental labyrinth hypoplasia 0.393199596369948 0.716020494853768 0.885201149425287 0.333333333333333 16.2 16 2 abnormal respiratory system morphology 0.393199596369948 0.716020494853768 0.885201149425287 0.333333333333333 16.2 16 2 dilated ureter 0.393199596369948 0.716020494853768 0.885201149425287 0.333333333333333 16.2 16 2 abnormal olfactory nerve morphology 0.393199596369948 0.716020494853768 0.885201149425287 0.333333333333333 16.2 16 2 abnormal Muller cell morphology 0.393199596369948 0.716020494853768 0.885201149425287 0.333333333333333 16.2 16 2 abnormal secondary palate development 0.393199596369948 0.716020494853768 0.885201149425287 0.333333333333333 16.2 16 2 increased susceptibility to pharmacologically induced seizures 0.116076529533457 0.376450700364617 0.885201149425287 0.333333333333333 16.2 16 2 abnormal autopod morphology 0.228353197769911 0.557299106998435 0.885201149425287 0.333333333333333 16.2 16 2 abnormal body weight 0.324358881068048 0.611244482315735 0.885201149425287 0.333333333333333 16.2 16 2 increased circulating total protein level 0.324358881068048 0.611244482315735 0.885201149425287 0.333333333333333 16.2 16 2 abnormal maternal nurturing 0.207189465404075 0.523780657692343 0.870689655172414 0.327868852459016 16.2 16 2 increased percent body fat/body weight 0.235845793517103 0.557299106998435 0.868178050397878 0.326923076923077 16.2 16 2 increased circulating insulin level 0.0862834761966073 0.299599125587008 0.863071120689655 0.325 16.2 16 2 impaired synaptic plasticity 0.314284592179153 0.593158515209138 0.859165821501014 0.323529411764706 16.2 16 2 abnormal bone remodeling 0.314284592179153 0.593158515209138 0.859165821501014 0.323529411764706 16.2 16 2 increased susceptibility to weight gain 0.314284592179153 0.593158515209138 0.859165821501014 0.323529411764706 16.2 16 2 abnormal CNS synaptic transmission 0.159116292407807 0.452086553243197 0.858376872169976 0.323232323232323 16.2 16 2 abnormal retinal photoreceptor layer morphology 0.331538683136096 0.622182176009837 0.856646273637375 0.32258064516129 16.2 16 2 abnormal eye electrophysiology 0.13554188092473 0.409175277670225 0.855938301510402 0.322314049586777 16.2 16 2 decreased exploration in new environment 0.192751959669175 0.505503953270504 0.853586822660099 0.321428571428571 16.2 16 2 abnormal inner ear vestibule morphology 0.371798155331692 0.688386982796863 0.849793103448276 0.32 16.2 16 2 abnormal primitive streak morphology 0.371798155331692 0.688386982796863 0.849793103448276 0.32 16.2 16 2 abnormal skin morphology 0.24606203594354 0.557299106998435 0.84496473354232 0.318181818181818 16.2 16 2 abnormal channel response 0.395738607632369 0.717754127951525 0.84496473354232 0.318181818181818 16.2 16 2 abnormal female reproductive system physiology 0.395738607632369 0.717754127951525 0.84496473354232 0.318181818181818 16.2 16 2 prolonged PR interval 0.395738607632369 0.717754127951525 0.84496473354232 0.318181818181818 16.2 16 2 decreased circulating estradiol level 0.395738607632369 0.717754127951525 0.84496473354232 0.318181818181818 16.2 16 2 abnormal temporal bone morphology 0.395738607632369 0.717754127951525 0.84496473354232 0.318181818181818 16.2 16 2 increased circulating creatine kinase level 0.395738607632369 0.717754127951525 0.84496473354232 0.318181818181818 16.2 16 2 abnormal hair follicle morphology 0.256792196188626 0.557299106998435 0.843048713738369 0.317460317460317 16.2 16 2 abnormal eye physiology 0.268178935315773 0.557299106998435 0.840941091954023 0.316666666666667 16.2 16 2 flaky skin 0.423193623825806 0.746712573706794 0.838611615245009 0.315789473684211 16.2 16 2 thin dermal layer 0.423193623825806 0.746712573706794 0.838611615245009 0.315789473684211 16.2 16 2 abnormal long term depression 0.423193623825806 0.746712573706794 0.838611615245009 0.315789473684211 16.2 16 2 decreased germ cell number 0.423193623825806 0.746712573706794 0.838611615245009 0.315789473684211 16.2 16 2 abnormal response to novelty 0.423193623825806 0.746712573706794 0.838611615245009 0.315789473684211 16.2 16 2 increased left ventricle weight 0.423193623825806 0.746712573706794 0.838611615245009 0.315789473684211 16.2 16 2 eyelids fail to open 0.423193623825806 0.746712573706794 0.838611615245009 0.315789473684211 16.2 16 2 decreased fertilization frequency 0.423193623825806 0.746712573706794 0.838611615245009 0.315789473684211 16.2 16 2 abnormal long term potentiation 0.373376171637589 0.690794516138715 0.829876077586207 0.3125 16.2 16 2 reduced male mating frequency 0.455384058206557 0.750429097680127 0.829876077586207 0.3125 16.2 16 2 abnormal molar crown morphology 0.455384058206557 0.750429097680127 0.829876077586207 0.3125 16.2 16 2 bowed tibia 0.455384058206557 0.750429097680127 0.829876077586207 0.3125 16.2 16 2 abnormal epididymis epithelium morphology 0.455384058206557 0.750429097680127 0.829876077586207 0.3125 16.2 16 2 abnormal wound healing 0.455384058206557 0.750429097680127 0.829876077586207 0.3125 16.2 16 2 abnormal amnion morphology 0.455384058206557 0.750429097680127 0.829876077586207 0.3125 16.2 16 2 decreased circulating growth hormone level 0.455384058206557 0.750429097680127 0.829876077586207 0.3125 16.2 16 2 abnormal intestinal lipid absorption 0.455384058206557 0.750429097680127 0.829876077586207 0.3125 16.2 16 2 decreased creatinine clearance 0.455384058206557 0.750429097680127 0.829876077586207 0.3125 16.2 16 2 abnormal urinary bladder physiology 0.455384058206557 0.750429097680127 0.829876077586207 0.3125 16.2 16 2 increased heart left ventricle size 0.455384058206557 0.750429097680127 0.829876077586207 0.3125 16.2 16 2 dilated respiratory conducting tubes 0.455384058206557 0.750429097680127 0.829876077586207 0.3125 16.2 16 2 decreased midbrain size 0.455384058206557 0.750429097680127 0.829876077586207 0.3125 16.2 16 2 abnormal cardiovascular system morphology 0.321746766751566 0.607011818198348 0.829876077586207 0.3125 16.2 16 2 obese 0.26270728150161 0.557299106998435 0.827720555306762 0.311688311688312 16.2 16 2 abnormal male meiosis 0.295769409799636 0.572397776191652 0.827155172413793 0.311475409836066 16.2 16 2 abnormal cartilage development 0.337623952261462 0.633363183446748 0.826187739463601 0.311111111111111 16.2 16 2 abnormal middle ear morphology 0.395259472258354 0.717754127951525 0.824152794292509 0.310344827586207 16.2 16 2 abnormal circulating glucose level 0.395259472258354 0.717754127951525 0.824152794292509 0.310344827586207 16.2 16 2 stomach inflammation 0.395259472258354 0.717754127951525 0.824152794292509 0.310344827586207 16.2 16 2 abnormal outer ear morphology 0.395259472258354 0.717754127951525 0.824152794292509 0.310344827586207 16.2 16 2 increased food intake 0.264661327842751 0.557299106998435 0.82197249589491 0.30952380952381 16.2 16 2 abnormal learning/memory/conditioning 0.32338188299317 0.609865378275595 0.820822884012539 0.309090909090909 16.2 16 2 absent corpus luteum 0.338589446988714 0.634695741811926 0.81710875331565 0.307692307692308 16.2 16 2 abnormal female meiosis 0.338589446988714 0.634695741811926 0.81710875331565 0.307692307692308 16.2 16 2 abnormal lens fiber morphology 0.373314261934902 0.690794516138715 0.81710875331565 0.307692307692308 16.2 16 2 circling 0.287684456060187 0.572397776191652 0.812302231237322 0.305882352941176 16.2 16 2 heart right ventricle hypertrophy 0.393525456395016 0.716351681509406 0.81143438697318 0.305555555555556 16.2 16 2 abnormal thoracic vertebrae morphology 0.338792914968664 0.634837948010962 0.810184102863822 0.305084745762712 16.2 16 2 blistering 0.447203221977759 0.750429097680127 0.808227136431784 0.304347826086957 16.2 16 2 bidirectional circling 0.447203221977759 0.750429097680127 0.808227136431784 0.304347826086957 16.2 16 2 failure of embryo implantation 0.447203221977759 0.750429097680127 0.808227136431784 0.304347826086957 16.2 16 2 abnormal cardiovascular development 0.447203221977759 0.750429097680127 0.808227136431784 0.304347826086957 16.2 16 2 enhanced long term potentiation 0.354315130690225 0.657485182836206 0.806165332512315 0.303571428571429 16.2 16 2 diarrhea 0.415663853404583 0.738413375564585 0.804728317659352 0.303030303030303 16.2 16 2 abnormal vertebrae morphology 0.278307848430691 0.563984336432866 0.803990034799114 0.302752293577982 16.2 16 2 abnormal female reproductive system morphology 0.411573050909609 0.738413375564585 0.796681034482759 0.3 16.2 16 2 abnormal hair cycle 0.440083733261822 0.750429097680127 0.796681034482759 0.3 16.2 16 2 emphysema 0.440083733261822 0.750429097680127 0.796681034482759 0.3 16.2 16 2 abnormal pain threshold 0.440083733261822 0.750429097680127 0.796681034482759 0.3 16.2 16 2 enhanced paired-pulse facilitation 0.440083733261822 0.750429097680127 0.796681034482759 0.3 16.2 16 2 abnormal synaptic transmission 0.440083733261822 0.750429097680127 0.796681034482759 0.3 16.2 16 2 abnormal basioccipital bone morphology 0.478750184224824 0.759739128076076 0.796681034482759 0.3 16.2 16 2 abnormal circulating cytokine level 0.478750184224824 0.759739128076076 0.796681034482759 0.3 16.2 16 2 abnormal heart electrocardiography waveform feature 0.478750184224824 0.759739128076076 0.796681034482759 0.3 16.2 16 2 impaired fertilization 0.352013667690917 0.655736368724952 0.796681034482759 0.3 16.2 16 2 abnormal nervous system electrophysiology 0.348843138634543 0.652686955512167 0.790358169129721 0.297619047619048 16.2 16 2 abnormal neuronal precursor proliferation 0.403573923509362 0.731698348928235 0.786845466155811 0.296296296296296 16.2 16 2 abnormal gametogenesis 0.427915033215883 0.750429097680127 0.784610109717868 0.295454545454545 16.2 16 2 abnormal neuron differentiation 0.341431690476377 0.639541664201798 0.782454587438424 0.294642857142857 16.2 16 2 decreased osteoblast cell number 0.457905212248511 0.750429097680127 0.781059837728195 0.294117647058824 16.2 16 2 hydroureter 0.515617232223355 0.802199862405791 0.781059837728195 0.294117647058824 16.2 16 2 abnormal urinary bladder morphology 0.515617232223355 0.802199862405791 0.781059837728195 0.294117647058824 16.2 16 2 abnormal touch/ nociception 0.515617232223355 0.802199862405791 0.781059837728195 0.294117647058824 16.2 16 2 abnormal cranial suture morphology 0.515617232223355 0.802199862405791 0.781059837728195 0.294117647058824 16.2 16 2 abnormal glutamate-mediated receptor currents 0.515617232223355 0.802199862405791 0.781059837728195 0.294117647058824 16.2 16 2 abnormal duodenum morphology 0.515617232223355 0.802199862405791 0.781059837728195 0.294117647058824 16.2 16 2 aminoaciduria 0.515617232223355 0.802199862405791 0.781059837728195 0.294117647058824 16.2 16 2 abnormal involuntary movement 0.515617232223355 0.802199862405791 0.781059837728195 0.294117647058824 16.2 16 2 abnormal excitatory postsynaptic potential 0.388902784205391 0.709754714388049 0.777249789739277 0.292682926829268 16.2 16 2 abnormal foregut morphology 0.497786185881758 0.783450260917983 0.774551005747126 0.291666666666667 16.2 16 2 decreased neuronal precursor cell number 0.484488526495073 0.768355250020079 0.770981646273637 0.290322580645161 16.2 16 2 abnormal podocyte morphology 0.484488526495073 0.768355250020079 0.770981646273637 0.290322580645161 16.2 16 2 abnormal epidermal layer morphology 0.425218676855292 0.746985493416341 0.769740129935032 0.289855072463768 16.2 16 2 increased grooming behavior 0.473729414188824 0.752491646101341 0.768727313974592 0.289473684210526 16.2 16 2 increased circulating corticosterone level 0.464595784853617 0.750429097680127 0.767174329501916 0.288888888888889 16.2 16 2 abnormal colon morphology 0.449433208345318 0.750429097680127 0.765173874926943 0.288135593220339 16.2 16 2 abnormal anxiety-related response 0.532563228216794 0.819011456067557 0.758743842364532 0.285714285714286 16.2 16 2 increased vasoconstriction 0.532563228216794 0.819011456067557 0.758743842364532 0.285714285714286 16.2 16 2 increased keratinocyte proliferation 0.532563228216794 0.819011456067557 0.758743842364532 0.285714285714286 16.2 16 2 myoclonus 0.513917370197138 0.802199862405791 0.758743842364532 0.285714285714286 16.2 16 2 abnormal jaw morphology 0.513917370197138 0.802199862405791 0.758743842364532 0.285714285714286 16.2 16 2 increased circulating luteinizing hormone level 0.513917370197138 0.802199862405791 0.758743842364532 0.285714285714286 16.2 16 2 absent corpus callosum 0.513917370197138 0.802199862405791 0.758743842364532 0.285714285714286 16.2 16 2 enhanced coordination 0.513917370197138 0.802199862405791 0.758743842364532 0.285714285714286 16.2 16 2 decreased placenta weight 0.546781531095672 0.835197456923847 0.743568965517241 0.28 16.2 16 2 abnormal stomach mucosa morphology 0.546781531095672 0.835197456923847 0.743568965517241 0.28 16.2 16 2 abnormal axon guidance 0.525434856301096 0.808799013025356 0.741098636728147 0.27906976744186 16.2 16 2 decreased food intake 0.50351662994369 0.792218606568583 0.739535137494544 0.278481012658228 16.2 16 2 short radius 0.540452628607657 0.830887462089955 0.737667624521073 0.277777777777778 16.2 16 2 cortical renal glomerulopathies 0.572837729512297 0.868332633858524 0.737667624521073 0.277777777777778 16.2 16 2 delayed kidney development 0.572837729512297 0.868332633858524 0.737667624521073 0.277777777777778 16.2 16 2 abnormal radius morphology 0.572837729512297 0.868332633858524 0.737667624521073 0.277777777777778 16.2 16 2 blepharoptosis 0.572837729512297 0.868332633858524 0.737667624521073 0.277777777777778 16.2 16 2 eye inflammation 0.572837729512297 0.868332633858524 0.737667624521073 0.277777777777778 16.2 16 2 abnormal body wall morphology 0.572837729512297 0.868332633858524 0.737667624521073 0.277777777777778 16.2 16 2 decreased activity of thyroid 0.572837729512297 0.868332633858524 0.737667624521073 0.277777777777778 16.2 16 2 abnormal eye anterior chamber morphology 0.572837729512297 0.868332633858524 0.737667624521073 0.277777777777778 16.2 16 2 abnormal parietal bone morphology 0.559120378935722 0.851315468636608 0.732580261593341 0.275862068965517 16.2 16 2 abnormal spinal nerve morphology 0.559120378935722 0.851315468636608 0.732580261593341 0.275862068965517 16.2 16 2 abnormal basisphenoid bone morphology 0.583872460935953 0.876020201231802 0.724255485893417 0.272727272727273 16.2 16 2 abnormal oogenesis 0.583872460935953 0.876020201231802 0.724255485893417 0.272727272727273 16.2 16 2 abnormal retinal outer plexiform layer morphology 0.583872460935953 0.876020201231802 0.724255485893417 0.272727272727273 16.2 16 2 syndactyly 0.565595628667272 0.859712267833693 0.720163646990064 0.271186440677966 16.2 16 2 abnormal hair shaft morphology 0.571487688842923 0.868332633858524 0.719225933908046 0.270833333333333 16.2 16 2 increased white adipose tissue amount 0.579984300755678 0.876020201231802 0.717730661696179 0.27027027027027 16.2 16 2 decreased circulating chloride level 0.579984300755678 0.876020201231802 0.717730661696179 0.27027027027027 16.2 16 2 abnormal pancreatic beta cell physiology 0.579984300755678 0.876020201231802 0.717730661696179 0.27027027027027 16.2 16 2 abnormal humerus morphology 0.579984300755678 0.876020201231802 0.717730661696179 0.27027027027027 16.2 16 2 no spontaneous movement 0.593614125568955 0.876020201231802 0.714970159151194 0.269230769230769 16.2 16 2 abnormal response to new environment 0.60240643190805 0.876020201231802 0.70816091954023 0.266666666666667 16.2 16 2 decreased urine osmolality 0.605233556348496 0.876020201231802 0.704547853624208 0.26530612244898 16.2 16 2 abnormal inhibitory postsynaptic currents 0.61053338629769 0.876020201231802 0.702953853955375 0.264705882352941 16.2 16 2 abnormal locomotor activation 0.622417338429353 0.880445339404615 0.700378931413414 0.263736263736264 16.2 16 2 abnormal ear morphology 0.626282052971757 0.88440341002966 0.698843012704174 0.263157894736842 16.2 16 2 abnormal neurotransmitter level 0.626282052971757 0.88440341002966 0.698843012704174 0.263157894736842 16.2 16 2 abnormal photoreceptor inner segment morphology 0.626282052971757 0.88440341002966 0.698843012704174 0.263157894736842 16.2 16 2 shortened RR interval 0.626282052971757 0.88440341002966 0.698843012704174 0.263157894736842 16.2 16 2 right-sided stomach 0.626282052971757 0.88440341002966 0.698843012704174 0.263157894736842 16.2 16 2 abnormal social investigation 0.629461681174648 0.888641278048773 0.697095905172414 0.2625 16.2 16 2 abnormal optic nerve morphology 0.624913311645871 0.883724765616318 0.695515188834154 0.261904761904762 16.2 16 2 abnormal carpal bone morphology 0.632108662921198 0.891871979022394 0.692766116941529 0.260869565217391 16.2 16 2 abnormal ulna morphology 0.632108662921198 0.891871979022394 0.692766116941529 0.260869565217391 16.2 16 2 abnormal femur morphology 0.686258895303175 0.954037053710206 0.673809830159547 0.253731343283582 16.2 16 2 abnormal dopamine level 0.675459342554068 0.949683375258695 0.663900862068965 0.25 16.2 16 2 abnormal fibula morphology 0.675459342554068 0.949683375258695 0.663900862068965 0.25 16.2 16 2 decreased paired-pulse facilitation 0.675459342554068 0.949683375258695 0.663900862068965 0.25 16.2 16 2 abnormal male reproductive system physiology 0.675459342554068 0.949683375258695 0.663900862068965 0.25 16.2 16 2 enhanced behavioral response to xenobiotic 0.675459342554068 0.949683375258695 0.663900862068965 0.25 16.2 16 2 nuclear cataracts 0.675459342554068 0.949683375258695 0.663900862068965 0.25 16.2 16 2 apnea 0.676882821934345 0.950319640186279 0.663900862068965 0.25 16.2 16 2 abnormal sensory capabilities/reflexes/nociception 0.676882821934345 0.950319640186279 0.663900862068965 0.25 16.2 16 2 abnormal systemic arterial blood pressure 0.684951529023161 0.954037053710206 0.663900862068965 0.25 16.2 16 2 abnormal epidermis stratum granulosum morphology 0.684951529023161 0.954037053710206 0.663900862068965 0.25 16.2 16 2 head bobbing 0.68816680076307 0.954037053710206 0.663900862068965 0.25 16.2 16 2 increased dopamine level 0.681906049357272 0.954037053710206 0.663900862068965 0.25 16.2 16 2 abnormal reflex 0.684951529023161 0.954037053710206 0.663900862068965 0.25 16.2 16 2 abnormal diaphragm morphology 0.681906049357272 0.954037053710206 0.663900862068965 0.25 16.2 16 2 short ulna 0.720140668875821 0.966760644254601 0.647708158116064 0.24390243902439 16.2 16 2 increased insulin secretion 0.718690995251995 0.966760644254601 0.645957595526561 0.243243243243243 16.2 16 2 abnormal tail morphology 0.756479771963877 1 0.643782654127482 0.242424242424242 16.2 16 2 decreased retinal photoreceptor cell number 0.717341102056292 0.966760644254601 0.641007728894174 0.241379310344828 16.2 16 2 small ears 0.720114378284467 0.966760644254601 0.632286535303777 0.238095238095238 16.2 16 2 abnormal vibrissa morphology 0.749899218010179 0.997312653699753 0.632286535303777 0.238095238095238 16.2 16 2 abnormal innervation 0.776701389009715 1 0.621524211298606 0.234042553191489 16.2 16 2 abnormal estrous cycle 0.752321219057931 0.997312653699753 0.619640804597701 0.233333333333333 16.2 16 2 small seminal vesicle 0.755273434451417 1 0.612831564986737 0.230769230769231 16.2 16 2 abnormal tracheal cartilage morphology 0.760185530445794 1 0.603546238244514 0.227272727272727 16.2 16 2 decreased cardiac output 0.760185530445794 1 0.603546238244514 0.227272727272727 16.2 16 2 cryptorchism 0.788825340774772 1 0.590134099616858 0.222222222222222 16.2 16 2 abnormal single cell response 0.788825340774772 1 0.590134099616858 0.222222222222222 16.2 16 2 abnormal serotonin level 0.812693415624559 1 0.580913254310345 0.21875 16.2 16 2 abnormal innervation pattern to muscle 0.795762438091515 1 0.577305097451274 0.217391304347826 16.2 16 2 abnormal crista ampullaris morphology 0.795762438091515 1 0.577305097451274 0.217391304347826 16.2 16 2 abnormal regulatory T cell physiology 0.795762438091515 1 0.577305097451274 0.217391304347826 16.2 16 2 impaired skeletal muscle contractility 0.83297514302167 1 0.574184529356943 0.216216216216216 16.2 16 2 abnormal intestinal mucosa morphology 0.869778470833731 1 0.555823977546111 0.209302325581395 16.2 16 2 abnormal malleus morphology 0.82704654760656 1 0.553250718390805 0.208333333333333 16.2 16 2 increased stereotypic behavior 0.82704654760656 1 0.553250718390805 0.208333333333333 16.2 16 2 abnormal impulse conducting system conduction 0.82704654760656 1 0.553250718390805 0.208333333333333 16.2 16 2 decreased ovulation rate 0.82704654760656 1 0.553250718390805 0.208333333333333 16.2 16 2 abnormal osteoblast morphology 0.82704654760656 1 0.553250718390805 0.208333333333333 16.2 16 2 abnormal nest building behavior 0.854316324484718 1 0.531120689655172 0.2 16.2 16 2 abnormal body temperature homeostasis 0.88864156094663 1 0.513987764182425 0.193548387096774 16.2 16 2 abnormal middle ear ossicle morphology 0.921256236104608 1 0.482836990595611 0.181818181818182 16.2 16 2 decreased circulating progesterone level 0.915403681601425 1 0.474214901477832 0.178571428571429 16.2 16 2 decreased pancreatic beta cell number 0.934172696290981 1 0.468635902636917 0.176470588235294 16.2 16 2 abnormal hypersensitivity reaction 0.000604117395676257 0.00728053262144219 1.88248789191945 1 16.1 16 1 decreased mortality induced by ionizing radiation 0.000604117395676257 0.00728053262144219 1.88248789191945 1 16.1 16 1 decreased DN2 thymocyte number 0.000604117395676257 0.00728053262144219 1.88248789191945 1 16.1 16 1 elevated level of mitotic sister chromatid exchange 0.000209500510302919 0.00297790011073435 1.88248789191945 1 16.1 16 1 abnormal extraembryonic tissue physiology 0.000209500510302919 0.00297790011073435 1.88248789191945 1 16.1 16 1 accumulation of giant lysosomes in kidney/renal tubule cells 0.000209500510302919 0.00297790011073435 1.88248789191945 1 16.1 16 1 abnormal NK cell morphology 0.000209500510302919 0.00297790011073435 1.88248789191945 1 16.1 16 1 enlarged pancreas 0.00174194115672424 0.0171947564577442 1.88248789191945 1 16.1 16 1 abnormal immature B cell morphology 0.00174194115672424 0.0171947564577442 1.88248789191945 1 16.1 16 1 myocardium hypoplasia 0.00174194115672424 0.0171947564577442 1.88248789191945 1 16.1 16 1 cerebral arteriovenous malformation 0.00174194115672424 0.0171947564577442 1.88248789191945 1 16.1 16 1 thymus cortex atrophy 0.00174194115672424 0.0171947564577442 1.88248789191945 1 16.1 16 1 ulcerated paws 0.00502251802915076 0.0390422299922266 1.88248789191945 1 16.1 16 1 vascular inflammation 0.00502251802915076 0.0390422299922266 1.88248789191945 1 16.1 16 1 decreased lysosomal enzyme secretion 0.00502251802915076 0.0390422299922266 1.88248789191945 1 16.1 16 1 abnormal response to vitamins 0.00502251802915076 0.0390422299922266 1.88248789191945 1 16.1 16 1 abnormal mesangial cell morphology 0.00502251802915076 0.0390422299922266 1.88248789191945 1 16.1 16 1 decreased DN3 thymocyte number 0.00502251802915076 0.0390422299922266 1.88248789191945 1 16.1 16 1 increased renal carcinoma incidence 0.00502251802915076 0.0390422299922266 1.88248789191945 1 16.1 16 1 aorta hypoplasia 0.00502251802915076 0.0390422299922266 1.88248789191945 1 16.1 16 1 prolonged ST segment 0.00502251802915076 0.0390422299922266 1.88248789191945 1 16.1 16 1 enlarged aortic valve 0.00502251802915076 0.0390422299922266 1.88248789191945 1 16.1 16 1 increased CD4-positive, alpha-beta memory T cell number 0.00502251802915076 0.0390422299922266 1.88248789191945 1 16.1 16 1 podocyte microvillus transformation 0.00502251802915076 0.0390422299922266 1.88248789191945 1 16.1 16 1 decreased small intestinal villus height 0.00502251802915076 0.0390422299922266 1.88248789191945 1 16.1 16 1 abnormal spleen periarteriolar lymphoid sheath morphology 9.96683802855695e-06 0.000226415612749182 1.74802447106806 0.928571428571429 16.1 16 1 altered tumor susceptibility 7.15011446995208e-05 0.00123513262111151 1.72561390092616 0.916666666666667 16.1 16 1 decreased red blood cell distribution width 7.15011446995208e-05 0.00123513262111151 1.72561390092616 0.916666666666667 16.1 16 1 abnormal gas homeostasis 0.000499765463601806 0.00626280398342313 1.6942391027275 0.9 16.1 16 1 abnormal left subclavian artery morphology 0.000499765463601806 0.00626280398342313 1.6942391027275 0.9 16.1 16 1 thick aortic valve 0.000499765463601806 0.00626280398342313 1.6942391027275 0.9 16.1 16 1 abnormal Peyer's patch follicle morphology 3.04014995240495e-06 7.87747188188263e-05 1.67332257059507 0.888888888888889 16.1 16 1 decreased cellular sensitivity to gamma-irradiation 3.04014995240495e-06 7.87747188188263e-05 1.67332257059507 0.888888888888889 16.1 16 1 heart hyperplasia 0.00130431919311013 0.0136418097502169 1.67332257059507 0.888888888888889 16.1 16 1 distorted hair follicle pattern 0.00130431919311013 0.0136418097502169 1.67332257059507 0.888888888888889 16.1 16 1 increased pheochromocytoma incidence 0.00130431919311013 0.0136418097502169 1.67332257059507 0.888888888888889 16.1 16 1 abnormal gut-associated lymphoid tissue morphology 0.00130431919311013 0.0136418097502169 1.67332257059507 0.888888888888889 16.1 16 1 abnormal leukopoiesis 0.00130431919311013 0.0136418097502169 1.67332257059507 0.888888888888889 16.1 16 1 eye opacity 0.00130431919311013 0.0136418097502169 1.67332257059507 0.888888888888889 16.1 16 1 abnormal level of surface class II molecules 2.0006019616576e-05 0.000417892972540379 1.64717690542952 0.875 16.1 16 1 decreased aerobic running capacity 0.00336643559328961 0.0290764185357914 1.64717690542952 0.875 16.1 16 1 abnormal eyelid aperture 0.00336643559328961 0.0290764185357914 1.64717690542952 0.875 16.1 16 1 abnormal mitotic spindle assembly checkpoint 0.00336643559328961 0.0290764185357914 1.64717690542952 0.875 16.1 16 1 pleural effusion 0.00336643559328961 0.0290764185357914 1.64717690542952 0.875 16.1 16 1 lung situs inversus 0.00336643559328961 0.0290764185357914 1.64717690542952 0.875 16.1 16 1 decreased alveolar lamellar body number 0.00336643559328961 0.0290764185357914 1.64717690542952 0.875 16.1 16 1 abnormal macrophage activation involved in immune response 0.00336643559328961 0.0290764185357914 1.64717690542952 0.875 16.1 16 1 decreased B-1 B cell number 1.67918277631981e-11 1.19341918745587e-09 1.64114329039131 0.871794871794872 16.1 16 1 decreased thymocyte apoptosis 5.0746052474345e-05 0.000924767806080096 1.63148950633019 0.866666666666667 16.1 16 1 increased hemangioma incidence 0.000127583845926548 0.00201501470947484 1.61356105021667 0.857142857142857 16.1 16 1 decreased response to antigen 0.000127583845926548 0.00201501470947484 1.61356105021667 0.857142857142857 16.1 16 1 cellular necrosis 0.00856888372301217 0.0600425303126557 1.61356105021667 0.857142857142857 16.1 16 1 decreased activated T cell number 0.00856888372301217 0.0600425303126557 1.61356105021667 0.857142857142857 16.1 16 1 abnormal gastrulation movements 0.00856888372301217 0.0600425303126557 1.61356105021667 0.857142857142857 16.1 16 1 aorta coarctation 0.00856888372301217 0.0600425303126557 1.61356105021667 0.857142857142857 16.1 16 1 increased cell nucleus count 0.00856888372301217 0.0600425303126557 1.61356105021667 0.857142857142857 16.1 16 1 decreased tidal volume 0.00856888372301217 0.0600425303126557 1.61356105021667 0.857142857142857 16.1 16 1 heart hemorrhage 0.00856888372301217 0.0600425303126557 1.61356105021667 0.857142857142857 16.1 16 1 decreased DN4 thymocyte number 0.00856888372301217 0.0600425303126557 1.61356105021667 0.857142857142857 16.1 16 1 arteritis 0.00856888372301217 0.0600425303126557 1.61356105021667 0.857142857142857 16.1 16 1 decreased brain cholesterol level 0.00856888372301217 0.0600425303126557 1.61356105021667 0.857142857142857 16.1 16 1 decreased T-helper 17 cell number 0.00856888372301217 0.0600425303126557 1.61356105021667 0.857142857142857 16.1 16 1 abnormal conotruncal ridge morphology 0.00856888372301217 0.0600425303126557 1.61356105021667 0.857142857142857 16.1 16 1 ductus venosus stenosis 0.00856888372301217 0.0600425303126557 1.61356105021667 0.857142857142857 16.1 16 1 abnormal T cell subpopulation ratio 4.07361042212692e-09 1.86438480985119e-07 1.59726245374984 0.848484848484849 16.1 16 1 increased B cell derived lymphoma incidence 9.26841309938764e-13 8.38370093990063e-11 1.58128982921234 0.84 16.1 16 1 abnormal megakaryocyte differentiation 3.17542928382355e-05 0.000629392856056659 1.56873990993287 0.833333333333333 16.1 16 1 abnormal neutrophil morphology 3.17542928382355e-05 0.000629392856056659 1.56873990993287 0.833333333333333 16.1 16 1 abnormal thymus involution 0.000781018175498894 0.00887115393403425 1.56873990993287 0.833333333333333 16.1 16 1 interstitial pneumonia 0.000781018175498894 0.00887115393403425 1.56873990993287 0.833333333333333 16.1 16 1 small intestinal inflammation 0.000781018175498894 0.00887115393403425 1.56873990993287 0.833333333333333 16.1 16 1 increased hepatocyte proliferation 0.000781018175498894 0.00887115393403425 1.56873990993287 0.833333333333333 16.1 16 1 jumpy 0.0214254023912834 0.120170661664752 1.56873990993287 0.833333333333333 16.1 16 1 delayed brain development 0.0214254023912834 0.120170661664752 1.56873990993287 0.833333333333333 16.1 16 1 abnormal gustatory system physiology 0.0214254023912834 0.120170661664752 1.56873990993287 0.833333333333333 16.1 16 1 abnormal blood gas level 0.0214254023912834 0.120170661664752 1.56873990993287 0.833333333333333 16.1 16 1 abnormal lymph node cortex morphology 0.0214254023912834 0.120170661664752 1.56873990993287 0.833333333333333 16.1 16 1 extremity edema 0.0214254023912834 0.120170661664752 1.56873990993287 0.833333333333333 16.1 16 1 decreased liver function 0.0214254023912834 0.120170661664752 1.56873990993287 0.833333333333333 16.1 16 1 increased glycerol level 0.0214254023912834 0.120170661664752 1.56873990993287 0.833333333333333 16.1 16 1 abnormal heart size 0.0214254023912834 0.120170661664752 1.56873990993287 0.833333333333333 16.1 16 1 absent brachial lymph nodes 0.0214254023912834 0.120170661664752 1.56873990993287 0.833333333333333 16.1 16 1 abnormal orbit morphology 0.0214254023912834 0.120170661664752 1.56873990993287 0.833333333333333 16.1 16 1 decreased DN1 thymic pro-T cell number 0.0214254023912834 0.120170661664752 1.56873990993287 0.833333333333333 16.1 16 1 kidney microaneurysm 0.0214254023912834 0.120170661664752 1.56873990993287 0.833333333333333 16.1 16 1 absent alveolar lamellar bodies 0.0214254023912834 0.120170661664752 1.56873990993287 0.833333333333333 16.1 16 1 podocyte hypertrophy 0.0214254023912834 0.120170661664752 1.56873990993287 0.833333333333333 16.1 16 1 absent midbrain 0.0214254023912834 0.120170661664752 1.56873990993287 0.833333333333333 16.1 16 1 delayed limb development 0.0214254023912834 0.120170661664752 1.56873990993287 0.833333333333333 16.1 16 1 absent thymus corticomedullary boundary 0.0214254023912834 0.120170661664752 1.56873990993287 0.833333333333333 16.1 16 1 additional anastomosis between intracranial vertebral arteries 0.0214254023912834 0.120170661664752 1.56873990993287 0.833333333333333 16.1 16 1 abnormal Wolffian duct connection 0.0214254023912834 0.120170661664752 1.56873990993287 0.833333333333333 16.1 16 1 abnormal platelet alpha-granule morphology 0.0214254023912834 0.120170661664752 1.56873990993287 0.833333333333333 16.1 16 1 increased cardiac cell glucose uptake 0.0214254023912834 0.120170661664752 1.56873990993287 0.833333333333333 16.1 16 1 increased brain size 7.68468558048395e-05 0.00130929146448314 1.55028414628661 0.823529411764706 16.1 16 1 aorta dilation 0.00189481712556256 0.0185025794813673 1.54021736611591 0.818181818181818 16.1 16 1 decreased embryonic cilium length 0.00189481712556256 0.0185025794813673 1.54021736611591 0.818181818181818 16.1 16 1 abnormal olfaction 0.000183952861524678 0.00270759019551855 1.52952141218455 0.8125 16.1 16 1 decreased fibroblast apoptosis 0.000183952861524678 0.00270759019551855 1.52952141218455 0.8125 16.1 16 1 decreased double-positive T cell number 2.29745404399557e-21 8.16416704919855e-19 1.52481519245475 0.81 16.1 16 1 failure to gastrulate 2.57267032272276e-10 1.50576880653479e-08 1.51417504350043 0.804347826086957 16.1 16 1 abnormal preimplantation embryo development 4.55091555377585e-06 0.000110442950634316 1.50599031353556 0.8 16.1 16 1 abnormal thymocyte activation 4.38864438324238e-05 0.000829731577337861 1.50599031353556 0.8 16.1 16 1 abnormal lymph node B cell domain morphology 0.000434935019735357 0.00556247229610129 1.50599031353556 0.8 16.1 16 1 abnormal dendritic cell morphology 0.000434935019735357 0.00556247229610129 1.50599031353556 0.8 16.1 16 1 enlarged testis 0.00452253411114343 0.0365253363684068 1.50599031353556 0.8 16.1 16 1 acrania 0.00452253411114343 0.0365253363684068 1.50599031353556 0.8 16.1 16 1 absent CD4-positive, alpha beta T cells 0.00452253411114343 0.0365253363684068 1.50599031353556 0.8 16.1 16 1 increased atrioventricular cushion size 0.00452253411114343 0.0365253363684068 1.50599031353556 0.8 16.1 16 1 abnormal embryonic erythrocyte morphology 0.00452253411114343 0.0365253363684068 1.50599031353556 0.8 16.1 16 1 decreased cochlear inner hair cell number 0.00452253411114343 0.0365253363684068 1.50599031353556 0.8 16.1 16 1 osteosclerosis 0.00452253411114343 0.0365253363684068 1.50599031353556 0.8 16.1 16 1 absent inguinal lymph nodes 0.00452253411114343 0.0365253363684068 1.50599031353556 0.8 16.1 16 1 decreased transitional stage T2 B cell number 0.00452253411114343 0.0365253363684068 1.50599031353556 0.8 16.1 16 1 increased circulating fructosamine level 0.00452253411114343 0.0365253363684068 1.50599031353556 0.8 16.1 16 1 thin ventricle myocardium compact layer 0.00452253411114343 0.0365253363684068 1.50599031353556 0.8 16.1 16 1 decreased macrophage cytokine production 0.00452253411114343 0.0365253363684068 1.50599031353556 0.8 16.1 16 1 decreased macrophage apoptosis 0.00452253411114343 0.0365253363684068 1.50599031353556 0.8 16.1 16 1 increased fatty acid oxidation 0.00452253411114343 0.0365253363684068 1.50599031353556 0.8 16.1 16 1 decreased B cell proliferation 2.7139815753298e-16 4.35550268944056e-14 1.50122452140412 0.79746835443038 16.1 16 1 decreased fertilization frequency 0.000102104196971012 0.00164660156246703 1.48617465151535 0.789473684210526 16.1 16 1 increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 0.000102104196971012 0.00164660156246703 1.48617465151535 0.789473684210526 16.1 16 1 lymphoid hyperplasia 2.56772539029378e-06 6.83124803032703e-05 1.47909762936528 0.785714285714286 16.1 16 1 amyloid beta deposits 0.0010139827491292 0.0110626407388547 1.47909762936528 0.785714285714286 16.1 16 1 abnormal positive T cell selection 0.0010139827491292 0.0110626407388547 1.47909762936528 0.785714285714286 16.1 16 1 increased B-1 B cell number 0.0010139827491292 0.0110626407388547 1.47909762936528 0.785714285714286 16.1 16 1 testis degeneration 0.0010139827491292 0.0110626407388547 1.47909762936528 0.785714285714286 16.1 16 1 abnormal T cell activation 1.7304416326769e-14 2.09974320062624e-12 1.47546348285578 0.783783783783784 16.1 16 1 small liver 4.37850258436061e-15 6.05084732144279e-13 1.47220206932162 0.782051282051282 16.1 16 1 abnormal B cell differentiation 3.13336456987295e-17 5.99557259042998e-15 1.46875428929979 0.78021978021978 16.1 16 1 abnormal thymus cortex morphology 0.000234670826187955 0.00327945887720526 1.46415724927068 0.777777777777778 16.1 16 1 increased effector memory CD4-positive, alpha-beta T cell number 0.000234670826187955 0.00327945887720526 1.46415724927068 0.777777777777778 16.1 16 1 increased effector memory CD8-positive, alpha-beta T cell number 0.000234670826187955 0.00327945887720526 1.46415724927068 0.777777777777778 16.1 16 1 decreased level of surface class I molecules 0.0105838429939178 0.0706773407983099 1.46415724927068 0.777777777777778 16.1 16 1 abnormal thymus physiology 0.0105838429939178 0.0706773407983099 1.46415724927068 0.777777777777778 16.1 16 1 increased neuronal precursor cell number 0.0105838429939178 0.0706773407983099 1.46415724927068 0.777777777777778 16.1 16 1 liver hyperplasia 0.0105838429939178 0.0706773407983099 1.46415724927068 0.777777777777778 16.1 16 1 absent cervical lymph nodes 0.0105838429939178 0.0706773407983099 1.46415724927068 0.777777777777778 16.1 16 1 decreased transitional stage T1 B cell number 0.0105838429939178 0.0706773407983099 1.46415724927068 0.777777777777778 16.1 16 1 decreased effector memory CD4-positive, alpha-beta T cell number 0.0105838429939178 0.0706773407983099 1.46415724927068 0.777777777777778 16.1 16 1 abnormal lung lobe morphology 0.0105838429939178 0.0706773407983099 1.46415724927068 0.777777777777778 16.1 16 1 increased cardiac muscle glycogen level 0.0105838429939178 0.0706773407983099 1.46415724927068 0.777777777777778 16.1 16 1 decreased platelet dense granule number 0.0105838429939178 0.0706773407983099 1.46415724927068 0.777777777777778 16.1 16 1 abnormal T cell proliferation 1.4230641739662e-06 4.18919779022595e-05 1.45740998084086 0.774193548387097 16.1 16 1 increased skin papilloma incidence 5.53907471454323e-05 0.000991255277152971 1.45464973466503 0.772727272727273 16.1 16 1 impaired humoral immune response 5.53907471454323e-05 0.000991255277152971 1.45464973466503 0.772727272727273 16.1 16 1 increased leukemia incidence 1.32507177628887e-05 0.000289132986273559 1.44806760916881 0.769230769230769 16.1 16 1 abnormal coping response 0.00232599053369055 0.0219996252948868 1.44806760916881 0.769230769230769 16.1 16 1 abnormal exocrine pancreas morphology 0.00232599053369055 0.0219996252948868 1.44806760916881 0.769230769230769 16.1 16 1 absent hypoglossal nerve 0.00232599053369055 0.0219996252948868 1.44806760916881 0.769230769230769 16.1 16 1 abnormal involuntary movement 0.000532047380114151 0.00656807869992035 1.43954956440899 0.764705882352941 16.1 16 1 decreased IgM level 6.3563234852044e-17 1.129382476389e-14 1.43612478352618 0.762886597938144 16.1 16 1 abnormal lymphocyte physiology 1.15630653935894e-08 4.91677353274422e-07 1.43232774385175 0.760869565217391 16.1 16 1 abnormal CD4-positive, alpha-beta T cell physiology 1.24414490783738e-12 1.10528944937339e-10 1.43175135441761 0.76056338028169 16.1 16 1 increased pre-B cell number 2.96500300292413e-05 0.000594793949175304 1.43069079785878 0.76 16.1 16 1 decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 2.96500300292413e-05 0.000594793949175304 1.43069079785878 0.76 16.1 16 1 abnormal embryonic erythropoiesis 7.13326765087126e-06 0.000164296326680947 1.42809426283544 0.758620689655172 16.1 16 1 increased double-negative T cell number 9.67509465213545e-11 5.942419246219e-09 1.41958103325073 0.754098360655738 16.1 16 1 abnormal lysosome morphology 9.2871671958041e-07 2.81729614628813e-05 1.41186591893959 0.75 16.1 16 1 subcutaneous edema 1.57404884533288e-05 0.000337538491617719 1.41186591893959 0.75 16.1 16 1 increased intestinal adenocarcinoma incidence 0.0011878814943674 0.0128471965966909 1.41186591893959 0.75 16.1 16 1 increased heart left ventricle size 0.0011878814943674 0.0128471965966909 1.41186591893959 0.75 16.1 16 1 schistocytosis 0.0241762281121798 0.129329822428059 1.41186591893959 0.75 16.1 16 1 dermal cysts 0.0241762281121798 0.129329822428059 1.41186591893959 0.75 16.1 16 1 abnormal pupil morphology 0.0241762281121798 0.129329822428059 1.41186591893959 0.75 16.1 16 1 dry eyes 0.0241762281121798 0.129329822428059 1.41186591893959 0.75 16.1 16 1 absent eyelids 0.0241762281121798 0.129329822428059 1.41186591893959 0.75 16.1 16 1 abnormal atrial thrombosis 0.0241762281121798 0.129329822428059 1.41186591893959 0.75 16.1 16 1 increased left ventricle systolic pressure 0.0241762281121798 0.129329822428059 1.41186591893959 0.75 16.1 16 1 lymph node inflammation 0.0241762281121798 0.129329822428059 1.41186591893959 0.75 16.1 16 1 abnormal kidney epithelium morphology 0.0241762281121798 0.129329822428059 1.41186591893959 0.75 16.1 16 1 abnormal somite size 0.0241762281121798 0.129329822428059 1.41186591893959 0.75 16.1 16 1 craniofacial phenotype 0.0241762281121798 0.129329822428059 1.41186591893959 0.75 16.1 16 1 abnormal olfactory bulb mitral cell layer morphology 0.0241762281121798 0.129329822428059 1.41186591893959 0.75 16.1 16 1 increased caudal vertebrae number 0.0241762281121798 0.129329822428059 1.41186591893959 0.75 16.1 16 1 increased heart right ventricle size 0.0241762281121798 0.129329822428059 1.41186591893959 0.75 16.1 16 1 abnormal stomach position or orientation 0.0241762281121798 0.129329822428059 1.41186591893959 0.75 16.1 16 1 abnormal bronchiole epithelium morphology 0.0241762281121798 0.129329822428059 1.41186591893959 0.75 16.1 16 1 increased cardiac stroke volume 0.0241762281121798 0.129329822428059 1.41186591893959 0.75 16.1 16 1 absent hypoglossal canal 0.0241762281121798 0.129329822428059 1.41186591893959 0.75 16.1 16 1 embryo cyst 0.0241762281121798 0.129329822428059 1.41186591893959 0.75 16.1 16 1 increased mammary adenocarcinoma incidence 0.000276757456386778 0.00380350371691774 1.41186591893959 0.75 16.1 16 1 abnormal Peyer's patch T cell area morphology 0.000276757456386778 0.00380350371691774 1.41186591893959 0.75 16.1 16 1 myocarditis 0.00523621397575357 0.0399287179155065 1.41186591893959 0.75 16.1 16 1 loss of dopaminergic neurons 0.00523621397575357 0.0399287179155065 1.41186591893959 0.75 16.1 16 1 abnormal defecation 0.00523621397575357 0.0399287179155065 1.41186591893959 0.75 16.1 16 1 pale placenta 0.00523621397575357 0.0399287179155065 1.41186591893959 0.75 16.1 16 1 abnormal B cell proliferation 0.00523621397575357 0.0399287179155065 1.41186591893959 0.75 16.1 16 1 hematuria 0.00523621397575357 0.0399287179155065 1.41186591893959 0.75 16.1 16 1 abnormal fatty acid level 0.00523621397575357 0.0399287179155065 1.41186591893959 0.75 16.1 16 1 decreased mammary gland epithelial cell proliferation 0.00523621397575357 0.0399287179155065 1.41186591893959 0.75 16.1 16 1 embryonic lethality between implantation and placentation, incomplete penetrance 0.00523621397575357 0.0399287179155065 1.41186591893959 0.75 16.1 16 1 increased T cell proliferation 2.82945525988685e-17 5.63061596717484e-15 1.40746758274351 0.747663551401869 16.1 16 1 increased B cell proliferation 4.60499854705503e-10 2.54554086351098e-08 1.40388927532976 0.745762711864407 16.1 16 1 decreased circulating total protein level 1.85111162296873e-09 9.20928032426945e-08 1.4033091557945 0.745454545454545 16.1 16 1 abnormal T-helper 1 physiology 3.01135678517603e-08 1.19852000050006e-06 1.40185268547193 0.74468085106383 16.1 16 1 abnormal liver development 2.0245057479526e-06 5.56459452821226e-05 1.39841957685445 0.742857142857143 16.1 16 1 abnormal interventricular septum morphology 1.61286647734816e-08 6.74286615530008e-07 1.39304104002039 0.74 16.1 16 1 abnormal B cell morphology 0.000143390193256537 0.0022432899731172 1.39140409402742 0.739130434782609 16.1 16 1 abnormal hematopoietic stem cell physiology 0.000143390193256537 0.0022432899731172 1.39140409402742 0.739130434782609 16.1 16 1 abnormal cytotoxic T cell physiology 2.63677556470884e-07 9.04686788581137e-06 1.38945534879769 0.738095238095238 16.1 16 1 decreased tumor incidence 0.000605857387995391 0.00728053262144219 1.38709634141433 0.736842105263158 16.1 16 1 decreased germ cell number 0.000605857387995391 0.00728053262144219 1.38709634141433 0.736842105263158 16.1 16 1 decreased susceptibility to weight gain 0.000605857387995391 0.00728053262144219 1.38709634141433 0.736842105263158 16.1 16 1 arrested T cell differentiation 1.7947588603928e-05 0.000379954269381029 1.38049112074093 0.733333333333333 16.1 16 1 abnormal spleen marginal zone morphology 1.7947588603928e-05 0.000379954269381029 1.38049112074093 0.733333333333333 16.1 16 1 abnormal placenta size 0.00260636400496225 0.024014616148056 1.38049112074093 0.733333333333333 16.1 16 1 abnormal trophectoderm morphology 0.00260636400496225 0.024014616148056 1.38049112074093 0.733333333333333 16.1 16 1 spleen hyperplasia 9.62278992026367e-12 7.14528057512115e-10 1.38049112074093 0.733333333333333 16.1 16 1 abnormal T cell differentiation 2.80217018218617e-15 3.98308475896463e-13 1.37924855447564 0.732673267326733 16.1 16 1 liver hypoplasia 1.83981947272076e-08 7.56454700560808e-07 1.37566422871037 0.730769230769231 16.1 16 1 decreased circulating glycerol level 7.41624490379121e-05 0.00127226959987453 1.37566422871037 0.730769230769231 16.1 16 1 abnormal erythrocyte osmotic lysis 7.41624490379121e-05 0.00127226959987453 1.37566422871037 0.730769230769231 16.1 16 1 decreased T cell proliferation 2.09135273140478e-21 8.00344602979906e-19 1.37370738058987 0.72972972972973 16.1 16 1 abnormal myelopoiesis 2.97890290179932e-07 1.01507136551038e-05 1.36908210321415 0.727272727272727 16.1 16 1 delayed hepatic development 0.0115297794060258 0.0751775746450547 1.36908210321415 0.727272727272727 16.1 16 1 focal hepatic necrosis 0.0115297794060258 0.0751775746450547 1.36908210321415 0.727272727272727 16.1 16 1 vasculitis 0.0115297794060258 0.0751775746450547 1.36908210321415 0.727272727272727 16.1 16 1 loss of cortex neurons 0.0115297794060258 0.0751775746450547 1.36908210321415 0.727272727272727 16.1 16 1 abnormal spinal cord ventral horn morphology 0.0115297794060258 0.0751775746450547 1.36908210321415 0.727272727272727 16.1 16 1 abnormal platelet aggregation 0.0115297794060258 0.0751775746450547 1.36908210321415 0.727272727272727 16.1 16 1 increased number of Howell-Jolly bodies 0.0115297794060258 0.0751775746450547 1.36908210321415 0.727272727272727 16.1 16 1 reduced sympathetic cervical ganglion size 0.0115297794060258 0.0751775746450547 1.36908210321415 0.727272727272727 16.1 16 1 thymus hypoplasia 1.4545420627505e-19 4.25667456599044e-17 1.3641216608112 0.72463768115942 16.1 16 1 abnormal thymus medulla morphology 0.00130522642032226 0.0136418097502169 1.35957458860849 0.722222222222222 16.1 16 1 abnormal redox activity 0.00130522642032226 0.0136418097502169 1.35957458860849 0.722222222222222 16.1 16 1 primary atelectasis 0.00130522642032226 0.0136418097502169 1.35957458860849 0.722222222222222 16.1 16 1 abnormal hypoglossal nerve topology 0.00130522642032226 0.0136418097502169 1.35957458860849 0.722222222222222 16.1 16 1 increased autoantibody level 2.53692278155066e-06 6.78558647215835e-05 1.35152976855755 0.717948717948718 16.1 16 1 increased hepatocyte apoptosis 2.53692278155066e-06 6.78558647215835e-05 1.35152976855755 0.717948717948718 16.1 16 1 abnormal cell death 3.29383468432208e-07 1.10721807800691e-05 1.35048044420308 0.717391304347826 16.1 16 1 increased sarcoma incidence 1.721886810587e-07 6.07545168983711e-06 1.34463420851389 0.714285714285714 16.1 16 1 abnormal hematopoietic system physiology 0.000657102911796094 0.00778354044329897 1.34463420851389 0.714285714285714 16.1 16 1 liver degeneration 0.000657102911796094 0.00778354044329897 1.34463420851389 0.714285714285714 16.1 16 1 abnormal kidney blood vessel morphology 0.00560600999509391 0.0415207446967326 1.34463420851389 0.714285714285714 16.1 16 1 increased lactate dehydrogenase level 0.00560600999509391 0.0415207446967326 1.34463420851389 0.714285714285714 16.1 16 1 failure of zygotic cell division 0.00560600999509391 0.0415207446967326 1.34463420851389 0.714285714285714 16.1 16 1 abnormal maternal decidual layer morphology 0.00560600999509391 0.0415207446967326 1.34463420851389 0.714285714285714 16.1 16 1 failure of atrioventricular cushion closure 0.0535666990619615 0.220790661005185 1.34463420851389 0.714285714285714 16.1 16 1 mammary gland hyperplasia 0.0535666990619615 0.220790661005185 1.34463420851389 0.714285714285714 16.1 16 1 abnormal lacrimal gland morphology 0.0535666990619615 0.220790661005185 1.34463420851389 0.714285714285714 16.1 16 1 limp posture 0.0535666990619615 0.220790661005185 1.34463420851389 0.714285714285714 16.1 16 1 abnormal circulating alanine transaminase level 0.0535666990619615 0.220790661005185 1.34463420851389 0.714285714285714 16.1 16 1 abnormal tumor incidence 0.0535666990619615 0.220790661005185 1.34463420851389 0.714285714285714 16.1 16 1 decreased cardiomyocyte apoptosis 0.0535666990619615 0.220790661005185 1.34463420851389 0.714285714285714 16.1 16 1 increased ectoderm apoptosis 0.0535666990619615 0.220790661005185 1.34463420851389 0.714285714285714 16.1 16 1 abnormal negative T cell selection 0.0535666990619615 0.220790661005185 1.34463420851389 0.714285714285714 16.1 16 1 increased prostate gland weight 0.0535666990619615 0.220790661005185 1.34463420851389 0.714285714285714 16.1 16 1 abnormal MHC II cell surface expression on macrophages 0.0535666990619615 0.220790661005185 1.34463420851389 0.714285714285714 16.1 16 1 increased chronic myelocytic leukemia incidence 0.0535666990619615 0.220790661005185 1.34463420851389 0.714285714285714 16.1 16 1 retinal pigment epithelium atrophy 0.0535666990619615 0.220790661005185 1.34463420851389 0.714285714285714 16.1 16 1 absent popliteal lymph nodes 0.0535666990619615 0.220790661005185 1.34463420851389 0.714285714285714 16.1 16 1 heart right ventricle outflow tract stenosis 0.0535666990619615 0.220790661005185 1.34463420851389 0.714285714285714 16.1 16 1 coronary fistula 0.0535666990619615 0.220790661005185 1.34463420851389 0.714285714285714 16.1 16 1 thick pulmonary valve 0.0535666990619615 0.220790661005185 1.34463420851389 0.714285714285714 16.1 16 1 increased right ventricle systolic pressure 0.0535666990619615 0.220790661005185 1.34463420851389 0.714285714285714 16.1 16 1 small lung lobe 0.0535666990619615 0.220790661005185 1.34463420851389 0.714285714285714 16.1 16 1 abnormal outer hair cell kinocilium morphology 0.0535666990619615 0.220790661005185 1.34463420851389 0.714285714285714 16.1 16 1 embryonic lethality at implantation, incomplete penetrance 0.0535666990619615 0.220790661005185 1.34463420851389 0.714285714285714 16.1 16 1 impaired mammary gland growth during pregnancy 0.0535666990619615 0.220790661005185 1.34463420851389 0.714285714285714 16.1 16 1 absent heart tube 0.0535666990619615 0.220790661005185 1.34463420851389 0.714285714285714 16.1 16 1 decreased neuron apoptosis 5.30048833365363e-06 0.000128009366310324 1.33755718636382 0.710526315789474 16.1 16 1 autoimmune response 4.15018820036786e-05 0.00079412254987808 1.33595914910413 0.709677419354839 16.1 16 1 decreased B cell number 3.005601760039e-26 1.66142986179933e-23 1.33419044767107 0.70873786407767 16.1 16 1 hemolytic anemia 0.000332298627622324 0.00443213317002965 1.33342892344294 0.708333333333333 16.1 16 1 increased hemangiosarcoma incidence 0.000332298627622324 0.00443213317002965 1.33342892344294 0.708333333333333 16.1 16 1 extramedullary hematopoiesis 3.93203584980228e-14 4.44588144381054e-12 1.33194898013169 0.707547169811321 16.1 16 1 decreased circulating serum albumin level 2.91312900980224e-13 2.89856336475323e-11 1.33105204479153 0.707070707070707 16.1 16 1 increased susceptibility to viral infection induced morbidity/mortality 2.13181479358043e-05 0.000440073800749487 1.32881498253138 0.705882352941177 16.1 16 1 increased regulatory T cell number 0.00276188336857518 0.025073667442813 1.32881498253138 0.705882352941177 16.1 16 1 abnormal circulating chemokine level 0.00276188336857518 0.025073667442813 1.32881498253138 0.705882352941177 16.1 16 1 abnormal erythropoiesis 8.07393112951586e-14 8.73213203681335e-12 1.32670575240037 0.704761904761905 16.1 16 1 increased T cell number 8.43907811896296e-12 6.36127479421829e-10 1.3262982874887 0.704545454545455 16.1 16 1 abnormal cell cycle 5.74907388178419e-15 7.52674804259903e-13 1.32592625430848 0.704347826086957 16.1 16 1 increased monocyte cell number 6.41146013227523e-13 6.01830455812627e-11 1.31774152434361 0.7 16.1 16 1 absent placental labyrinth 0.00137375722841548 0.0140126068033545 1.31774152434361 0.7 16.1 16 1 dilated vasculature 0.00137375722841548 0.0140126068033545 1.31774152434361 0.7 16.1 16 1 increased skin tumor incidence 0.00137375722841548 0.0140126068033545 1.31774152434361 0.7 16.1 16 1 absent ductus venosus valve 0.00137375722841548 0.0140126068033545 1.31774152434361 0.7 16.1 16 1 fused cornea and lens 0.0247268970537246 0.130038385668372 1.31774152434361 0.7 16.1 16 1 abnormal immune cell physiology 0.0247268970537246 0.130038385668372 1.31774152434361 0.7 16.1 16 1 ketoaciduria 0.0247268970537246 0.130038385668372 1.31774152434361 0.7 16.1 16 1 peritoneal inflammation 0.0247268970537246 0.130038385668372 1.31774152434361 0.7 16.1 16 1 abnormal respiratory conducting tube morphology 0.0247268970537246 0.130038385668372 1.31774152434361 0.7 16.1 16 1 absent axillary lymph nodes 0.0247268970537246 0.130038385668372 1.31774152434361 0.7 16.1 16 1 abnormal vibrissa follicle morphology 0.0247268970537246 0.130038385668372 1.31774152434361 0.7 16.1 16 1 abnormal heart and great artery attachment 0.0247268970537246 0.130038385668372 1.31774152434361 0.7 16.1 16 1 thick aortic valve cusps 0.0247268970537246 0.130038385668372 1.31774152434361 0.7 16.1 16 1 lethality during fetal growth through weaning, complete penetrance 0.0247268970537246 0.130038385668372 1.31774152434361 0.7 16.1 16 1 decreased circulating lactate level 0.0247268970537246 0.130038385668372 1.31774152434361 0.7 16.1 16 1 abnormal definitive hematopoiesis 4.74265526370616e-12 3.86798523556363e-10 1.31571734381467 0.698924731182796 16.1 16 1 pancreas inflammation 0.000688288077493288 0.00803810606931715 1.30955679437875 0.695652173913043 16.1 16 1 abnormal humoral immune response 3.57691153227842e-13 3.48924213197748e-11 1.30877729628686 0.695238095238095 16.1 16 1 decreased IgG level 9.8186825141716e-14 1.03931798953199e-11 1.30586997907926 0.693693693693694 16.1 16 1 decreased leukocyte cell number 1.3772200447661e-16 2.36264473196943e-14 1.30537481556458 0.693430656934307 16.1 16 1 increased B cell number 2.69460781279221e-14 3.19182711158125e-12 1.30326084825193 0.692307692307692 16.1 16 1 decreased IgA level 4.02343511049484e-07 1.33443931164746e-05 1.30326084825193 0.692307692307692 16.1 16 1 decreased Peyer's patch number 0.000346824216773692 0.00457679172002418 1.30326084825193 0.692307692307692 16.1 16 1 increased foot pad pigmentation 0.0117842167203954 0.0760395307185047 1.30326084825193 0.692307692307692 16.1 16 1 lymphoid hypoplasia 0.0117842167203954 0.0760395307185047 1.30326084825193 0.692307692307692 16.1 16 1 increased mortality induced by gamma-irradiation 0.000175568449428198 0.00263088263826893 1.29826751166859 0.689655172413793 16.1 16 1 abnormal CD8-positive, alpha-beta T cell physiology 0.000175568449428198 0.00263088263826893 1.29826751166859 0.689655172413793 16.1 16 1 increased double-positive T cell number 0.000175568449428198 0.00263088263826893 1.29826751166859 0.689655172413793 16.1 16 1 pale liver 2.03465306680323e-09 9.92392059543731e-08 1.29739030389043 0.689189189189189 16.1 16 1 abnormal embryonic hematopoiesis 8.92127215002038e-05 0.00147944429821171 1.29421042569462 0.6875 16.1 16 1 increased fatty acid level 8.92127215002038e-05 0.00147944429821171 1.29421042569462 0.6875 16.1 16 1 increased cochlear outer hair cell number 0.00572702552827093 0.0418384023541085 1.29421042569462 0.6875 16.1 16 1 overriding aortic valve 1.57023936112737e-06 4.48962116184406e-05 1.29421042569462 0.6875 16.1 16 1 abnormal trophoblast layer morphology 8.10352749498798e-07 2.53553769104184e-05 1.29190345523884 0.686274509803922 16.1 16 1 embryonic lethality between somite formation and embryo turning, complete penetrance 7.83754053743509e-09 3.36135898049479e-07 1.29084884017334 0.685714285714286 16.1 16 1 kyphoscoliosis 0.00282052599036382 0.0251471627277061 1.28801803131331 0.684210526315789 16.1 16 1 abnormal triglyceride level 0.00282052599036382 0.0251471627277061 1.28801803131331 0.684210526315789 16.1 16 1 altered susceptibility to infection 0.00282052599036382 0.0251471627277061 1.28801803131331 0.684210526315789 16.1 16 1 increased malignant tumor incidence 0.00282052599036382 0.0251471627277061 1.28801803131331 0.684210526315789 16.1 16 1 increased susceptibility to ischemic brain injury 0.00282052599036382 0.0251471627277061 1.28801803131331 0.684210526315789 16.1 16 1 increased liver adenoma incidence 0.00282052599036382 0.0251471627277061 1.28801803131331 0.684210526315789 16.1 16 1 abnormal blastocyst morphology 0.00282052599036382 0.0251471627277061 1.28801803131331 0.684210526315789 16.1 16 1 abnormal response to infection 1.10212097621299e-09 5.89575468458022e-08 1.28676387548924 0.683544303797468 16.1 16 1 decreased T cell number 3.27351045133353e-18 7.7551021406592e-16 1.28617185162198 0.683229813664596 16.1 16 1 arrested B cell differentiation 1.19074202022192e-05 0.000264461676366253 1.2856014871645 0.682926829268293 16.1 16 1 abnormal cell differentiation 1.19074202022192e-05 0.000264461676366253 1.2856014871645 0.682926829268293 16.1 16 1 intestinal inflammation 0.00140254769472335 0.0141534985420865 1.28351447176326 0.681818181818182 16.1 16 1 abnormal oogenesis 0.00140254769472335 0.0141534985420865 1.28351447176326 0.681818181818182 16.1 16 1 abnormal lysosome physiology 0.00140254769472335 0.0141534985420865 1.28351447176326 0.681818181818182 16.1 16 1 abnormal vascular branching morphogenesis 0.00140254769472335 0.0141534985420865 1.28351447176326 0.681818181818182 16.1 16 1 abnormal mesenteric lymph node morphology 0.00140254769472335 0.0141534985420865 1.28351447176326 0.681818181818182 16.1 16 1 increased cellular sensitivity to gamma-irradiation 3.14294214911959e-06 8.10162548801553e-05 1.28169388386005 0.680851063829787 16.1 16 1 enlarged spleen 6.01749389606635e-31 4.27671887613287e-28 1.28113759311185 0.680555555555556 16.1 16 1 embryonic lethality before implantation, complete penetrance 3.19536216156389e-14 3.69695971018148e-12 1.28009176650523 0.68 16.1 16 1 spontaneous skin ulceration 0.000702559158979265 0.00811591249868132 1.28009176650523 0.68 16.1 16 1 decreased lymphocyte cell number 1.66922968847136e-14 2.07610442503626e-12 1.279503489039 0.6796875 16.1 16 1 atrioventricular septal defect 8.34687736031667e-07 2.56331573256639e-05 1.27867102092642 0.679245283018868 16.1 16 1 decreased double-negative T cell number 0.000179147735174919 0.00267645640388956 1.27523373323576 0.67741935483871 16.1 16 1 increased mean corpuscular hemoglobin 2.26603275337702e-11 1.56576568722926e-09 1.27400695715761 0.676767676767677 16.1 16 1 abnormal direction of heart looping 9.10189480747948e-05 0.00149276768954089 1.27344769159257 0.676470588235294 16.1 16 1 decreased cytotoxic T cell cytolysis 9.10189480747948e-05 0.00149276768954089 1.27344769159257 0.676470588235294 16.1 16 1 spleen hypoplasia 6.15675441284103e-12 4.78591456310689e-10 1.27292038405982 0.676190476190476 16.1 16 1 pale yolk sac 1.16683525449883e-09 6.17553765014008e-08 1.27011231262035 0.674698795180723 16.1 16 1 kidney failure 1.21444302180842e-05 0.000267338674048536 1.26958485734102 0.674418604651163 16.1 16 1 embryonic lethality between implantation and placentation, complete penetrance 6.23330600675236e-06 0.000145590128561469 1.26863314455441 0.673913043478261 16.1 16 1 abnormal leukocyte migration 1.6503717698356e-06 4.66511338348416e-05 1.26705915802271 0.673076923076923 16.1 16 1 abnormal T-helper 2 physiology 8.51011607993445e-07 2.59741272991864e-05 1.26640094547308 0.672727272727273 16.1 16 1 increased lung adenocarcinoma incidence 3.23506210406794e-06 8.21144590190714e-05 1.2549919279463 0.666666666666667 16.1 16 1 abnormal trophoblast giant cell morphology 9.15164111175824e-05 0.00149276768954089 1.2549919279463 0.666666666666667 16.1 16 1 underdeveloped hair follicles 0.00567519726508105 0.0415207446967326 1.2549919279463 0.666666666666667 16.1 16 1 right pulmonary isomerism 0.00567519726508105 0.0415207446967326 1.2549919279463 0.666666666666667 16.1 16 1 abnormal bile duct morphology 0.00567519726508105 0.0415207446967326 1.2549919279463 0.666666666666667 16.1 16 1 acidosis 0.00567519726508105 0.0415207446967326 1.2549919279463 0.666666666666667 16.1 16 1 absent inner cell mass 0.00567519726508105 0.0415207446967326 1.2549919279463 0.666666666666667 16.1 16 1 increased susceptibility to autoimmune disorder 0.00567519726508105 0.0415207446967326 1.2549919279463 0.666666666666667 16.1 16 1 decreased tumor latency 0.00567519726508105 0.0415207446967326 1.2549919279463 0.666666666666667 16.1 16 1 abnormal aerobic respiration 0.00567519726508105 0.0415207446967326 1.2549919279463 0.666666666666667 16.1 16 1 impaired leukocyte tethering or rolling 0.00567519726508105 0.0415207446967326 1.2549919279463 0.666666666666667 16.1 16 1 abnormal urinary bladder urothelium morphology 0.0513609983487038 0.220182631272341 1.2549919279463 0.666666666666667 16.1 16 1 abnormal cholinergic neuron morphology 0.0513609983487038 0.220182631272341 1.2549919279463 0.666666666666667 16.1 16 1 abnormal germ cell morphology 0.0513609983487038 0.220182631272341 1.2549919279463 0.666666666666667 16.1 16 1 biliary cyst 0.0513609983487038 0.220182631272341 1.2549919279463 0.666666666666667 16.1 16 1 premature bone ossification 0.0513609983487038 0.220182631272341 1.2549919279463 0.666666666666667 16.1 16 1 decreased cellular sensitivity to ionizing radiation 0.0513609983487038 0.220182631272341 1.2549919279463 0.666666666666667 16.1 16 1 decreased susceptibility to atherosclerosis 0.0513609983487038 0.220182631272341 1.2549919279463 0.666666666666667 16.1 16 1 abnormal hippocampus granule cell morphology 0.0513609983487038 0.220182631272341 1.2549919279463 0.666666666666667 16.1 16 1 trigeminal neuroma 0.0513609983487038 0.220182631272341 1.2549919279463 0.666666666666667 16.1 16 1 abnormal infrahyoid muscle connection 0.0513609983487038 0.220182631272341 1.2549919279463 0.666666666666667 16.1 16 1 abnormal apoptosis 1.66672617597987e-06 4.68472470367223e-05 1.2549919279463 0.666666666666667 16.1 16 1 small heart 6.28834772510403e-06 0.000146189392207442 1.2549919279463 0.666666666666667 16.1 16 1 impaired macrophage chemotaxis 4.66932545997466e-05 0.000857191666545164 1.2549919279463 0.666666666666667 16.1 16 1 abnormal skeleton physiology 0.000179901350892009 0.00267966832541241 1.2549919279463 0.666666666666667 16.1 16 1 increased metastatic potential 0.000354897808037727 0.00467094337298332 1.2549919279463 0.666666666666667 16.1 16 1 abnormal atrioventricular cushion morphology 0.000703107193353095 0.00811591249868132 1.2549919279463 0.666666666666667 16.1 16 1 abnormal fetal cardiomyocyte proliferation 0.000703107193353095 0.00811591249868132 1.2549919279463 0.666666666666667 16.1 16 1 thick interventricular septum 0.000703107193353095 0.00811591249868132 1.2549919279463 0.666666666666667 16.1 16 1 increased incidence of induced tumors 0.00280706586165426 0.0251471627277061 1.2549919279463 0.666666666666667 16.1 16 1 vascular ring 0.00280706586165426 0.0251471627277061 1.2549919279463 0.666666666666667 16.1 16 1 absent segment of posterior cerebral artery 0.00280706586165426 0.0251471627277061 1.2549919279463 0.666666666666667 16.1 16 1 macrocytosis 0.0116053019753572 0.0751775746450547 1.2549919279463 0.666666666666667 16.1 16 1 delayed intramembranous bone ossification 0.0116053019753572 0.0751775746450547 1.2549919279463 0.666666666666667 16.1 16 1 abnormal energy homeostasis 0.0116053019753572 0.0751775746450547 1.2549919279463 0.666666666666667 16.1 16 1 bicuspid aortic valve 0.0116053019753572 0.0751775746450547 1.2549919279463 0.666666666666667 16.1 16 1 heterochrony 0.0116053019753572 0.0751775746450547 1.2549919279463 0.666666666666667 16.1 16 1 abnormal supraoccipital bone morphology 0.0241169102665702 0.129329822428059 1.2549919279463 0.666666666666667 16.1 16 1 impaired embryo implantation 0.0241169102665702 0.129329822428059 1.2549919279463 0.666666666666667 16.1 16 1 abnormal respiratory function 0.0241169102665702 0.129329822428059 1.2549919279463 0.666666666666667 16.1 16 1 decreased synaptic depression 0.0241169102665702 0.129329822428059 1.2549919279463 0.666666666666667 16.1 16 1 dilated bile duct 0.0241169102665702 0.129329822428059 1.2549919279463 0.666666666666667 16.1 16 1 abnormal vascular endothelial cell development 0.0241169102665702 0.129329822428059 1.2549919279463 0.666666666666667 16.1 16 1 abnormal palatine bone morphology 0.0241169102665702 0.129329822428059 1.2549919279463 0.666666666666667 16.1 16 1 decreased keratinocyte proliferation 0.0241169102665702 0.129329822428059 1.2549919279463 0.666666666666667 16.1 16 1 increased fibrosarcoma incidence 0.0241169102665702 0.129329822428059 1.2549919279463 0.666666666666667 16.1 16 1 persistent right dorsal aorta 0.0241169102665702 0.129329822428059 1.2549919279463 0.666666666666667 16.1 16 1 abnormal pulmonary valve cusp morphology 0.0241169102665702 0.129329822428059 1.2549919279463 0.666666666666667 16.1 16 1 prenatal growth retardation 0.0241169102665702 0.129329822428059 1.2549919279463 0.666666666666667 16.1 16 1 lethality throughout fetal growth and development, incomplete penetrance 4.05541574483673e-18 8.77204057850553e-16 1.25148636390176 0.664804469273743 16.1 16 1 increased spleen weight 6.56802855513498e-12 5.02706800950716e-10 1.24943886631822 0.663716814159292 16.1 16 1 abnormal cell nucleus morphology 1.22208859809158e-05 0.000267836598039896 1.24164094998942 0.659574468085106 16.1 16 1 omphalocele 2.3806683591705e-05 0.000483421432117274 1.24073065603782 0.659090909090909 16.1 16 1 thick ventricular wall 4.64676590324948e-05 0.000856209643283932 1.2396871483372 0.658536585365854 16.1 16 1 liver inflammation 3.45027764762723e-12 2.90934428761787e-10 1.23930452884697 0.658333333333333 16.1 16 1 decreased hair follicle number 9.09052877878055e-05 0.00149276768954089 1.2384788762628 0.657894736842105 16.1 16 1 embryonic lethality between implantation and somite formation, complete penetrance 3.51606789894642e-23 1.45770314977154e-20 1.23706347183278 0.657142857142857 16.1 16 1 internal hemorrhage 2.29744832828209e-07 7.93736488416904e-06 1.23626070514113 0.656716417910448 16.1 16 1 decreased erythrocyte cell number 2.71772707562991e-15 3.97667417684083e-13 1.23500798004907 0.656050955414013 16.1 16 1 abnormal cytokine secretion 5.19940888733436e-15 6.99109708499687e-13 1.23461868236276 0.655844155844156 16.1 16 1 lordosis 0.000692876416242667 0.00807274044685543 1.23335413608516 0.655172413793103 16.1 16 1 decreased circulating calcium level 3.21229062058572e-06 8.19545940380204e-05 1.23217389289273 0.654545454545455 16.1 16 1 heart inflammation 0.0013745029387009 0.0140126068033545 1.23085746779349 0.653846153846154 16.1 16 1 pulmonary edema 0.0013745029387009 0.0140126068033545 1.23085746779349 0.653846153846154 16.1 16 1 decreased bone resorption 0.0013745029387009 0.0140126068033545 1.23085746779349 0.653846153846154 16.1 16 1 increased thymocyte apoptosis 0.0013745029387009 0.0140126068033545 1.23085746779349 0.653846153846154 16.1 16 1 increased tumor incidence 3.42642941792656e-12 2.90934428761787e-10 1.22968967133448 0.653225806451613 16.1 16 1 increased T cell derived lymphoma incidence 1.20924471643089e-05 0.000267338674048536 1.22937984778413 0.653061224489796 16.1 16 1 increased inflammatory response 1.20490672674946e-09 6.30990627955637e-08 1.22857104525269 0.652631578947368 16.1 16 1 abnormal pulmonary artery morphology 0.00274178447702972 0.0249823768740345 1.22770949473008 0.652173913043478 16.1 16 1 increased bone mineral content 8.82992180979521e-11 5.4911076254664e-09 1.22620770941542 0.651376146788991 16.1 16 1 impaired macrophage phagocytosis 4.57981911031579e-05 0.000847011155160633 1.22580606915685 0.651162790697674 16.1 16 1 abnormal neural tube closure 1.63883191392662e-08 6.79432397648747e-07 1.2247511585982 0.650602409638554 16.1 16 1 absent mesoderm 1.63738659131082e-06 4.65485616672647e-05 1.22361712974764 0.65 16.1 16 1 abnormal cell proliferation 0.00550738226255358 0.0411399801144205 1.22361712974764 0.65 16.1 16 1 abnormal vascular regression 0.00550738226255358 0.0411399801144205 1.22361712974764 0.65 16.1 16 1 abnormal circulating enzyme level 0.00550738226255358 0.0411399801144205 1.22361712974764 0.65 16.1 16 1 anencephaly 0.00550738226255358 0.0411399801144205 1.22361712974764 0.65 16.1 16 1 abnormal physiological neovascularization 0.00550738226255358 0.0411399801144205 1.22361712974764 0.65 16.1 16 1 abnormal induced retinal neovascularization 0.00550738226255358 0.0411399801144205 1.22361712974764 0.65 16.1 16 1 abnormal spleen morphology 3.78655250000996e-16 5.88690583985923e-14 1.22253524015459 0.649425287356322 16.1 16 1 abnormal cell morphology 4.55918087582309e-11 3.00190278710189e-09 1.22196582457929 0.649122807017544 16.1 16 1 abnormal branching of the mammary ductal tree 0.00017482503844377 0.00263088263826893 1.22107322719099 0.648648648648649 16.1 16 1 abnormal cell adhesion 6.1279727874338e-06 0.000143805021780581 1.2201310410589 0.648148148148148 16.1 16 1 lethality throughout fetal growth and development, complete penetrance 2.7789684477414e-17 5.63061596717484e-15 1.21866321424259 0.647368421052632 16.1 16 1 enlarged liver sinusoidal spaces 0.000342852422723566 0.00453641171023867 1.21808040065376 0.647058823529412 16.1 16 1 abnormal spleen red pulp morphology 0.000342852422723566 0.00453641171023867 1.21808040065376 0.647058823529412 16.1 16 1 decreased regulatory T cell number 0.000342852422723566 0.00453641171023867 1.21808040065376 0.647058823529412 16.1 16 1 abnormal bone marrow cavity morphology 0.0111631194877131 0.0738517545895915 1.21808040065376 0.647058823529412 16.1 16 1 abnormal embryonic-extraembryonic boundary morphology 0.0111631194877131 0.0738517545895915 1.21808040065376 0.647058823529412 16.1 16 1 enhanced behavioral response to cocaine 0.0111631194877131 0.0738517545895915 1.21808040065376 0.647058823529412 16.1 16 1 increased trabecular bone mass 0.0111631194877131 0.0738517545895915 1.21808040065376 0.647058823529412 16.1 16 1 abnormal lymph node morphology 2.30390439768081e-05 0.000469750999117296 1.21577343019798 0.645833333333333 16.1 16 1 vertebral transformation 2.30390439768081e-05 0.000469750999117296 1.21577343019798 0.645833333333333 16.1 16 1 abnormal placenta morphology 5.95624348458028e-08 2.2794085642913e-06 1.21527699351762 0.645569620253165 16.1 16 1 decreased thymus weight 0.000674443395061014 0.00791357521327487 1.21450831736739 0.645161290322581 16.1 16 1 pale kidney 0.000674443395061014 0.00791357521327487 1.21450831736739 0.645161290322581 16.1 16 1 abnormal CD8-positive, alpha beta T cell morphology 0.000674443395061014 0.00791357521327487 1.21450831736739 0.645161290322581 16.1 16 1 abnormal intestine physiology 0.000674443395061014 0.00791357521327487 1.21450831736739 0.645161290322581 16.1 16 1 irregular heartbeat 4.47646616511181e-05 0.000830985789978777 1.21315886368142 0.644444444444444 16.1 16 1 abnormal ectoderm development 4.47646616511181e-05 0.000830985789978777 1.21315886368142 0.644444444444444 16.1 16 1 abnormal myocardial trabeculae morphology 4.47646616511181e-05 0.000830985789978777 1.21315886368142 0.644444444444444 16.1 16 1 abnormal cell migration 4.47646616511181e-05 0.000830985789978777 1.21315886368142 0.644444444444444 16.1 16 1 decreased embryo size 1.59677643072709e-40 1.32399379047787e-37 1.21298382993973 0.644351464435146 16.1 16 1 abnormal spleen germinal center morphology 0.0013315892288779 0.0138301804043164 1.2101707876625 0.642857142857143 16.1 16 1 increased bone resorption 0.0013315892288779 0.0138301804043164 1.2101707876625 0.642857142857143 16.1 16 1 abnormal renal tubule epithelium morphology 0.0013315892288779 0.0138301804043164 1.2101707876625 0.642857142857143 16.1 16 1 abnormal fluid regulation 0.0229049888259382 0.127037145383548 1.2101707876625 0.642857142857143 16.1 16 1 vascular smooth muscle hypoplasia 0.0229049888259382 0.127037145383548 1.2101707876625 0.642857142857143 16.1 16 1 split sternum 0.0229049888259382 0.127037145383548 1.2101707876625 0.642857142857143 16.1 16 1 lysosomal protein accumulation 0.0229049888259382 0.127037145383548 1.2101707876625 0.642857142857143 16.1 16 1 decreased cornea thickness 0.0229049888259382 0.127037145383548 1.2101707876625 0.642857142857143 16.1 16 1 multiple persisting craniopharyngeal ducts 0.0229049888259382 0.127037145383548 1.2101707876625 0.642857142857143 16.1 16 1 increased leukocyte cell number 4.4990164563608e-13 4.30434747507596e-11 1.20738878585178 0.641379310344828 16.1 16 1 abnormal osteoclast physiology 1.56768797481711e-06 4.48962116184406e-05 1.2059688057609 0.640625 16.1 16 1 abnormal primitive streak morphology 0.00264063643191247 0.0241936763328997 1.20479225082845 0.64 16.1 16 1 abnormal egg cylinder morphology 0.00264063643191247 0.0241936763328997 1.20479225082845 0.64 16.1 16 1 increased cellular sensitivity to ionizing radiation 0.00264063643191247 0.0241936763328997 1.20479225082845 0.64 16.1 16 1 anemia 3.59348332918267e-18 8.12617252849262e-16 1.2044353810859 0.639810426540284 16.1 16 1 hepatic necrosis 4.34404735460269e-05 0.000824871587372075 1.2015880161188 0.638297872340426 16.1 16 1 abnormal embryonic neuroepithelium morphology 5.82171830740128e-06 0.000137919278949149 1.20089744829344 0.637931034482759 16.1 16 1 glomerulosclerosis 5.82171830740128e-06 0.000137919278949149 1.20089744829344 0.637931034482759 16.1 16 1 preweaning lethality, complete penetrance 1.22851172745931e-59 6.11184584411007e-56 1.20072200673781 0.637837837837838 16.1 16 1 abnormal embryo size 2.93919151365513e-10 1.70028811400398e-08 1.19946131166549 0.63716814159292 16.1 16 1 abnormal ovarian folliculogenesis 0.000649987729462262 0.00773609797625539 1.19794684031238 0.636363636363636 16.1 16 1 increased cardiomyocyte apoptosis 0.000649987729462262 0.00773609797625539 1.19794684031238 0.636363636363636 16.1 16 1 abnormal enterocyte morphology 0.00526497265378336 0.0399287179155065 1.19794684031238 0.636363636363636 16.1 16 1 increased activated T cell number 0.00526497265378336 0.0399287179155065 1.19794684031238 0.636363636363636 16.1 16 1 aphakia 0.00526497265378336 0.0399287179155065 1.19794684031238 0.636363636363636 16.1 16 1 abnormal blood-brain barrier function 0.00526497265378336 0.0399287179155065 1.19794684031238 0.636363636363636 16.1 16 1 abnormal cerebral cortex pyramidal cell morphology 0.00526497265378336 0.0399287179155065 1.19794684031238 0.636363636363636 16.1 16 1 increased adenoma incidence 0.00526497265378336 0.0399287179155065 1.19794684031238 0.636363636363636 16.1 16 1 abnormal sphenoid bone morphology 0.0478218529371976 0.211103565539093 1.19794684031238 0.636363636363636 16.1 16 1 abnormal large intestine morphology 0.0478218529371976 0.211103565539093 1.19794684031238 0.636363636363636 16.1 16 1 abnormal eye distance/ position 0.0478218529371976 0.211103565539093 1.19794684031238 0.636363636363636 16.1 16 1 impaired myelopoiesis 0.0478218529371976 0.211103565539093 1.19794684031238 0.636363636363636 16.1 16 1 abnormal larynx morphology 0.0478218529371976 0.211103565539093 1.19794684031238 0.636363636363636 16.1 16 1 fatigue 0.0478218529371976 0.211103565539093 1.19794684031238 0.636363636363636 16.1 16 1 dilated renal glomerular capsule 0.0478218529371976 0.211103565539093 1.19794684031238 0.636363636363636 16.1 16 1 abnormal superovulation 0.0478218529371976 0.211103565539093 1.19794684031238 0.636363636363636 16.1 16 1 abnormal palate development 0.0478218529371976 0.211103565539093 1.19794684031238 0.636363636363636 16.1 16 1 abnormal aorta smooth muscle morphology 0.0478218529371976 0.211103565539093 1.19794684031238 0.636363636363636 16.1 16 1 common atrioventricular valve 0.0478218529371976 0.211103565539093 1.19794684031238 0.636363636363636 16.1 16 1 abnormal extraembryonic ectoderm morphology 0.0478218529371976 0.211103565539093 1.19794684031238 0.636363636363636 16.1 16 1 abnormal pulmonary alveolar sac morphology 0.0478218529371976 0.211103565539093 1.19794684031238 0.636363636363636 16.1 16 1 abnormal phrenic nerve innervation pattern to diaphragm 0.0478218529371976 0.211103565539093 1.19794684031238 0.636363636363636 16.1 16 1 thin hypoglossal nerve 0.0478218529371976 0.211103565539093 1.19794684031238 0.636363636363636 16.1 16 1 distended pericardium 2.16808829892995e-05 0.000445712367238698 1.19465577756427 0.634615384615385 16.1 16 1 pallor 8.09995565859652e-15 1.03326357439789e-12 1.19403517716034 0.634285714285714 16.1 16 1 increased erythrocyte cell number 5.62874033164024e-06 0.000134629726682261 1.19224233154898 0.633333333333333 16.1 16 1 salivary gland inflammation 0.00127665764859665 0.0136295532226789 1.19224233154898 0.633333333333333 16.1 16 1 abnormal microglial cell physiology 0.00127665764859665 0.0136295532226789 1.19224233154898 0.633333333333333 16.1 16 1 decreased cell proliferation 2.11158449226688e-15 3.18337359061447e-13 1.19054639651122 0.632432432432432 16.1 16 1 pericardial edema 1.47143060911363e-06 4.25602748856994e-05 1.19039675518436 0.632352941176471 16.1 16 1 decreased circulating alanine transaminase level 1.47143060911363e-06 4.25602748856994e-05 1.19039675518436 0.632352941176471 16.1 16 1 decreased mean corpuscular hemoglobin 1.47143060911363e-06 4.25602748856994e-05 1.19039675518436 0.632352941176471 16.1 16 1 abnormal facial morphology 1.08316386939235e-05 0.000243834400462759 1.18893972121228 0.631578947368421 16.1 16 1 incomplete somite formation 0.00031868746813971 0.0042735044582077 1.18893972121228 0.631578947368421 16.1 16 1 enlarged adrenal glands 0.0105689194503106 0.0706773407983099 1.18893972121228 0.631578947368421 16.1 16 1 absent amnion 0.0105689194503106 0.0706773407983099 1.18893972121228 0.631578947368421 16.1 16 1 decreased eye pigmentation 0.0105689194503106 0.0706773407983099 1.18893972121228 0.631578947368421 16.1 16 1 eyelids fail to open 0.0105689194503106 0.0706773407983099 1.18893972121228 0.631578947368421 16.1 16 1 Leydig cell hypoplasia 0.0105689194503106 0.0706773407983099 1.18893972121228 0.631578947368421 16.1 16 1 embryonic lethality between implantation and somite formation, incomplete penetrance 0.0105689194503106 0.0706773407983099 1.18893972121228 0.631578947368421 16.1 16 1 embryonic lethality during organogenesis, complete penetrance 3.92874270970667e-43 4.88637374519767e-40 1.18663968901351 0.630357142857143 16.1 16 1 abnormal fertility/fecundity 7.4007797190111e-07 2.33030880392913e-05 1.18622524696294 0.63013698630137 16.1 16 1 abnormal liver physiology 7.1751087847594e-09 3.18715769680161e-07 1.18596737190925 0.63 16.1 16 1 increased cell proliferation 2.08548386787419e-05 0.000432303426778088 1.18527015417151 0.62962962962963 16.1 16 1 abnormal heart valve morphology 0.00251587570579218 0.0233081594717246 1.18527015417151 0.62962962962963 16.1 16 1 rectal prolapse 0.00251587570579218 0.0233081594717246 1.18527015417151 0.62962962962963 16.1 16 1 abnormal eye muscle morphology 0.00251587570579218 0.0233081594717246 1.18527015417151 0.62962962962963 16.1 16 1 decreased circulating fructosamine level 0.00251587570579218 0.0233081594717246 1.18527015417151 0.62962962962963 16.1 16 1 embryonic growth arrest 2.76451606810314e-18 6.87673371940655e-16 1.18374784470044 0.62882096069869 16.1 16 1 decreased glycogen level 0.000621309126178752 0.00744822386202239 1.18327810349223 0.628571428571429 16.1 16 1 increased urine protein level 3.72369547797348e-07 1.24331442972604e-05 1.18258854748786 0.628205128205128 16.1 16 1 abnormal double-strand DNA break repair 0.000156845284059399 0.00240093934829388 1.18202728097268 0.627906976744186 16.1 16 1 thrombocytopenia 4.93966325510142e-12 3.91128720761477e-10 1.18142343561841 0.627586206896552 16.1 16 1 impaired hematopoiesis 4.01757777997179e-05 0.000771716195187632 1.18116887336122 0.627450980392157 16.1 16 1 increased hemoglobin content 1.03976686597442e-05 0.000235129098101034 1.18054325425457 0.627118644067797 16.1 16 1 embryonic lethality, complete penetrance 1.38056312199759e-24 6.24391048358002e-22 1.18024319242599 0.626959247648903 16.1 16 1 small spleen 4.95691552871948e-08 1.92661365276402e-06 1.17914076746603 0.626373626373626 16.1 16 1 abnormal dendritic cell physiology 3.49580260934452e-09 1.65634456966562e-07 1.17875410054769 0.626168224299065 16.1 16 1 decreased circulating HDL cholesterol level 1.25904291245395e-10 7.54667287886556e-09 1.17655493244966 0.625 16.1 16 1 abnormal spongiotrophoblast layer morphology 0.00121377929984557 0.0130422289778223 1.17655493244966 0.625 16.1 16 1 bradykinesia 0.00121377929984557 0.0130422289778223 1.17655493244966 0.625 16.1 16 1 increased fibroblast apoptosis 0.00121377929984557 0.0130422289778223 1.17655493244966 0.625 16.1 16 1 abnormal bone marrow cell number 0.0214024293871677 0.120170661664752 1.17655493244966 0.625 16.1 16 1 decreased mast cell number 0.0214024293871677 0.120170661664752 1.17655493244966 0.625 16.1 16 1 abnormal mouth morphology 0.0214024293871677 0.120170661664752 1.17655493244966 0.625 16.1 16 1 poor circulation 0.0214024293871677 0.120170661664752 1.17655493244966 0.625 16.1 16 1 large intestinal inflammation 0.0214024293871677 0.120170661664752 1.17655493244966 0.625 16.1 16 1 small pancreas 0.0214024293871677 0.120170661664752 1.17655493244966 0.625 16.1 16 1 abnormal exoccipital bone morphology 0.102550817311597 0.365990183734001 1.17655493244966 0.625 16.1 16 1 pointed snout 0.102550817311597 0.365990183734001 1.17655493244966 0.625 16.1 16 1 enlarged pituitary gland 0.102550817311597 0.365990183734001 1.17655493244966 0.625 16.1 16 1 increased sensitivity to skin irradiation 0.102550817311597 0.365990183734001 1.17655493244966 0.625 16.1 16 1 abnormal erythrocyte cell number 0.102550817311597 0.365990183734001 1.17655493244966 0.625 16.1 16 1 abnormal hepatobiliary system morphology 0.102550817311597 0.365990183734001 1.17655493244966 0.625 16.1 16 1 abnormal pulmonary circulation 0.102550817311597 0.365990183734001 1.17655493244966 0.625 16.1 16 1 early eyelid opening 0.102550817311597 0.365990183734001 1.17655493244966 0.625 16.1 16 1 colon polyps 0.102550817311597 0.365990183734001 1.17655493244966 0.625 16.1 16 1 liver cysts 0.102550817311597 0.365990183734001 1.17655493244966 0.625 16.1 16 1 increased cardiac output 0.102550817311597 0.365990183734001 1.17655493244966 0.625 16.1 16 1 abnormal platelet shape 0.102550817311597 0.365990183734001 1.17655493244966 0.625 16.1 16 1 tau protein deposits 0.102550817311597 0.365990183734001 1.17655493244966 0.625 16.1 16 1 long femur 0.102550817311597 0.365990183734001 1.17655493244966 0.625 16.1 16 1 absent interparietal bone 0.102550817311597 0.365990183734001 1.17655493244966 0.625 16.1 16 1 enlarged inguinal lymph nodes 0.102550817311597 0.365990183734001 1.17655493244966 0.625 16.1 16 1 abnormal base-excision repair 0.102550817311597 0.365990183734001 1.17655493244966 0.625 16.1 16 1 abnormal olfactory bulb glomerular layer morphology 0.102550817311597 0.365990183734001 1.17655493244966 0.625 16.1 16 1 decreased hippocampus pyramidal cell number 0.102550817311597 0.365990183734001 1.17655493244966 0.625 16.1 16 1 abnormal cerebellum deep nucleus morphology 0.102550817311597 0.365990183734001 1.17655493244966 0.625 16.1 16 1 abnormal circulating serum amyloid protein level 0.102550817311597 0.365990183734001 1.17655493244966 0.625 16.1 16 1 ostium secundum atrial septal defect 0.102550817311597 0.365990183734001 1.17655493244966 0.625 16.1 16 1 myocardial trabeculae hypoplasia 0.102550817311597 0.365990183734001 1.17655493244966 0.625 16.1 16 1 decreased lung compliance 0.102550817311597 0.365990183734001 1.17655493244966 0.625 16.1 16 1 abnormal foramen magnum morphology 0.102550817311597 0.365990183734001 1.17655493244966 0.625 16.1 16 1 abnormal branching involved in ureteric bud morphogenesis 0.102550817311597 0.365990183734001 1.17655493244966 0.625 16.1 16 1 lethality during fetal growth through weaning, incomplete penetrance 0.102550817311597 0.365990183734001 1.17655493244966 0.625 16.1 16 1 decreased cranium length 0.102550817311597 0.365990183734001 1.17655493244966 0.625 16.1 16 1 small thymus medulla 0.102550817311597 0.365990183734001 1.17655493244966 0.625 16.1 16 1 increased testis apoptosis 0.102550817311597 0.365990183734001 1.17655493244966 0.625 16.1 16 1 abnormal umbilical vein topology 0.102550817311597 0.365990183734001 1.17655493244966 0.625 16.1 16 1 increased mammary gland apoptosis 0.102550817311597 0.365990183734001 1.17655493244966 0.625 16.1 16 1 decreased basal metabolism 0.102550817311597 0.365990183734001 1.17655493244966 0.625 16.1 16 1 decreased vascular endothelial cell proliferation 0.102550817311597 0.365990183734001 1.17655493244966 0.625 16.1 16 1 thymus atrophy 7.74428561613918e-05 0.00131494269420793 1.17655493244966 0.625 16.1 16 1 abnormal adrenal gland morphology 0.0049776469766872 0.0390422299922266 1.17655493244966 0.625 16.1 16 1 small lymph nodes 0.0049776469766872 0.0390422299922266 1.17655493244966 0.625 16.1 16 1 abnormal impulse conducting system conduction 0.0049776469766872 0.0390422299922266 1.17655493244966 0.625 16.1 16 1 abnormal cellular extravasation 0.0049776469766872 0.0390422299922266 1.17655493244966 0.625 16.1 16 1 abnormal truncus arteriosus septation 0.0049776469766872 0.0390422299922266 1.17655493244966 0.625 16.1 16 1 decreased neutrophil cell number 8.94191185296265e-10 4.88857268884497e-08 1.17454372743692 0.623931623931624 16.1 16 1 increased lymphocyte cell number 2.59489376944316e-06 6.86680665052113e-05 1.17314462829763 0.623188405797101 16.1 16 1 decreased birth body size 1.69540792243587e-09 8.60679021848823e-08 1.17242666952878 0.62280701754386 16.1 16 1 trabecula carnea hypoplasia 0.000149372899408101 0.00232228179548532 1.17132579941655 0.622222222222222 16.1 16 1 skin inflammation 0.000589865576082649 0.00721027331943779 1.17019517605804 0.621621621621622 16.1 16 1 increased trabecular bone volume 0.000589865576082649 0.00721027331943779 1.17019517605804 0.621621621621622 16.1 16 1 increased neutrophil cell number 1.56695239747733e-11 1.12979538803619e-09 1.16844076050173 0.620689655172414 16.1 16 1 decreased granulocyte number 0.00237675564955373 0.0223101119934524 1.16844076050173 0.620689655172414 16.1 16 1 decreased trophoblast giant cell number 0.00237675564955373 0.0223101119934524 1.16844076050173 0.620689655172414 16.1 16 1 polychromatophilia 0.00237675564955373 0.0223101119934524 1.16844076050173 0.620689655172414 16.1 16 1 blood in lymph vessels 0.00237675564955373 0.0223101119934524 1.16844076050173 0.620689655172414 16.1 16 1 abnormal reproductive system morphology 0.000288301595401479 0.00391885365333977 1.16534964737871 0.619047619047619 16.1 16 1 abnormal spleen white pulp morphology 0.000288301595401479 0.00391885365333977 1.16534964737871 0.619047619047619 16.1 16 1 abnormal eye pigmentation 0.00989539641401498 0.0679028926341028 1.16534964737871 0.619047619047619 16.1 16 1 left pulmonary isomerism 0.00989539641401498 0.0679028926341028 1.16534964737871 0.619047619047619 16.1 16 1 abnormal erythrocyte physiology 0.00989539641401498 0.0679028926341028 1.16534964737871 0.619047619047619 16.1 16 1 complete atrioventricular septal defect 0.00989539641401498 0.0679028926341028 1.16534964737871 0.619047619047619 16.1 16 1 anophthalmia 1.63670937643454e-07 5.81616367697275e-06 1.16333521410753 0.617977528089888 16.1 16 1 lung inflammation 1.05567157456963e-10 6.40483668717553e-09 1.16271310971495 0.617647058823529 16.1 16 1 increased neuron apoptosis 6.19336881843992e-07 2.00077986180121e-05 1.16202956291324 0.617283950617284 16.1 16 1 decreased bone marrow cell number 2.35264071660804e-06 6.39584019952185e-05 1.16043774159418 0.616438356164384 16.1 16 1 increased oxygen consumption 3.10321141771726e-07 1.05023651722064e-05 1.16013788688059 0.616279069767442 16.1 16 1 abnormal lipid homeostasis 3.75675911309795e-10 2.10908097495234e-08 1.15845408733505 0.615384615384615 16.1 16 1 increased grip strength 1.55627302207256e-07 5.57011387396473e-06 1.15845408733505 0.615384615384615 16.1 16 1 ventricular hypoplasia 0.00466645002105097 0.0375049900722594 1.15845408733505 0.615384615384615 16.1 16 1 thick skin 0.00466645002105097 0.0375049900722594 1.15845408733505 0.615384615384615 16.1 16 1 abnormal nerve conduction 0.00466645002105097 0.0375049900722594 1.15845408733505 0.615384615384615 16.1 16 1 absent teeth 0.0438492199404498 0.199223624843596 1.15845408733505 0.615384615384615 16.1 16 1 uterus hypoplasia 0.0438492199404498 0.199223624843596 1.15845408733505 0.615384615384615 16.1 16 1 abnormal grip strength 0.0438492199404498 0.199223624843596 1.15845408733505 0.615384615384615 16.1 16 1 abnormal pulmonary alveolus epithelial cell morphology 0.0438492199404498 0.199223624843596 1.15845408733505 0.615384615384615 16.1 16 1 abnormal tail bud morphology 0.0438492199404498 0.199223624843596 1.15845408733505 0.615384615384615 16.1 16 1 axonal dystrophy 0.0438492199404498 0.199223624843596 1.15845408733505 0.615384615384615 16.1 16 1 orthokeratosis 0.0438492199404498 0.199223624843596 1.15845408733505 0.615384615384615 16.1 16 1 abnormal aorta tunica media morphology 0.0438492199404498 0.199223624843596 1.15845408733505 0.615384615384615 16.1 16 1 increased hepatocellular carcinoma incidence 3.44930850514108e-05 0.000672953326003015 1.15591361784528 0.614035087719298 16.1 16 1 increased macrophage cell number 3.44930850514108e-05 0.000672953326003015 1.15591361784528 0.614035087719298 16.1 16 1 renal interstitial fibrosis 0.000272090741700715 0.00376014288878071 1.15516302458693 0.613636363636364 16.1 16 1 decreased macrophage cell number 0.000272090741700715 0.00376014288878071 1.15516302458693 0.613636363636364 16.1 16 1 abnormal postnatal growth/weight/body size 0.00223016355002807 0.0212142708630778 1.15378290149902 0.612903225806452 16.1 16 1 inner cell mass degeneration 0.00223016355002807 0.0212142708630778 1.15378290149902 0.612903225806452 16.1 16 1 preaxial polydactyly 0.00223016355002807 0.0212142708630778 1.15378290149902 0.612903225806452 16.1 16 1 abnormal embryonic tissue morphology 4.58582134311043e-11 3.00190278710189e-09 1.15254360729762 0.612244897959184 16.1 16 1 abnormal inflammatory response 4.22856782861648e-06 0.000103123161506701 1.15040926728411 0.611111111111111 16.1 16 1 hydrops fetalis 4.22856782861648e-06 0.000103123161506701 1.15040926728411 0.611111111111111 16.1 16 1 abnormal macrophage chemotaxis 0.019786997266135 0.115269685478948 1.15040926728411 0.611111111111111 16.1 16 1 increased adipocyte glucose uptake 0.019786997266135 0.115269685478948 1.15040926728411 0.611111111111111 16.1 16 1 abnormal small intestine morphology 6.58255109331791e-05 0.00114905935751778 1.15040926728411 0.611111111111111 16.1 16 1 ventricular septal defect 3.21113507108404e-10 1.83625252628081e-08 1.14887128698025 0.610294117647059 16.1 16 1 increased bone trabecula number 0.000523080188042914 0.00651902555153569 1.14785847068259 0.609756097560976 16.1 16 1 increased sacral vertebrae number 1.61291302723886e-05 0.00034438808199628 1.14714105913841 0.609375 16.1 16 1 abnormal immune system morphology 0.000255703731501718 0.00355342476039399 1.1458621950814 0.608695652173913 16.1 16 1 abnormal corneal stroma morphology 0.00918993203984457 0.0637655675010136 1.1458621950814 0.608695652173913 16.1 16 1 abnormal vertebral artery topology 0.00918993203984457 0.0637655675010136 1.1458621950814 0.608695652173913 16.1 16 1 increased granulocyte number 3.98825980731472e-06 9.82257056504492e-05 1.14475615049156 0.608108108108108 16.1 16 1 kidney cysts 3.98825980731472e-06 9.82257056504492e-05 1.14475615049156 0.608108108108108 16.1 16 1 abnormal gastrulation 0.000125570573766772 0.0019958901101907 1.14425734606868 0.607843137254902 16.1 16 1 abnormal heart development 1.96392069434628e-11 1.37612752878489e-09 1.14379011154599 0.607594936708861 16.1 16 1 double outlet right ventricle 3.32299247301632e-08 1.31205456771875e-06 1.1435674109791 0.607476635514019 16.1 16 1 rib bifurcation 0.00434613662465973 0.0362785733350371 1.14293907723681 0.607142857142857 16.1 16 1 small superior cervical ganglion 0.00434613662465973 0.0362785733350371 1.14293907723681 0.607142857142857 16.1 16 1 abnormal somite shape 0.00434613662465973 0.0362785733350371 1.14293907723681 0.607142857142857 16.1 16 1 hypoxia 0.00434613662465973 0.0362785733350371 1.14293907723681 0.607142857142857 16.1 16 1 abnormal brainstem morphology 0.00434613662465973 0.0362785733350371 1.14293907723681 0.607142857142857 16.1 16 1 decreased rib number 4.96393967856652e-07 1.63547019211049e-05 1.14218366476012 0.606741573033708 16.1 16 1 increased osteoclast cell number 3.06042139611361e-05 0.000611469736773703 1.1418369180495 0.60655737704918 16.1 16 1 abnormal vascular development 1.51718450165663e-05 0.000326752939209599 1.14090175267845 0.606060606060606 16.1 16 1 enlarged pericardium 0.00208115094658912 0.0201043222510308 1.14090175267845 0.606060606060606 16.1 16 1 myeloid hyperplasia 0.00208115094658912 0.0201043222510308 1.14090175267845 0.606060606060606 16.1 16 1 increased bone marrow cell number 0.00100567200826183 0.0110626407388547 1.13940056616177 0.605263157894737 16.1 16 1 abnormal vasculogenesis 0.000489352424512894 0.00618745501064827 1.1382484927885 0.604651162790698 16.1 16 1 abnormal homeostasis 0.000489352424512894 0.00618745501064827 1.1382484927885 0.604651162790698 16.1 16 1 prenatal lethality, complete penetrance 1.48067103333073e-18 3.87702020569493e-16 1.13761858216715 0.60431654676259 16.1 16 1 abnormal bone mineralization 7.44296124014461e-09 3.24813440085258e-07 1.13571583562082 0.603305785123967 16.1 16 1 decreased percent body fat/body weight 7.07480206752588e-06 0.000163707629236936 1.13465023622542 0.602739726027397 16.1 16 1 increased embryonic tissue cell apoptosis 3.52282054007702e-06 8.7630160934416e-05 1.13431962718223 0.602564102564103 16.1 16 1 decreased circulating cholesterol level 1.87327519086282e-12 1.63500773237588e-10 1.13155009896797 0.601092896174863 16.1 16 1 abnormal head morphology 0.000109907922787906 0.0017581733629255 1.12949273515167 0.6 16.1 16 1 decreased circulating alkaline phosphatase level 0.000223445477215227 0.00315807173052771 1.12949273515167 0.6 16.1 16 1 abnormal midbrain development 0.00193335975775535 0.0187494440445085 1.12949273515167 0.6 16.1 16 1 decreased triglyceride level 0.00193335975775535 0.0187494440445085 1.12949273515167 0.6 16.1 16 1 abnormal hippocampus pyramidal cell morphology 0.00193335975775535 0.0187494440445085 1.12949273515167 0.6 16.1 16 1 gastrointestinal hemorrhage 0.00402690265098935 0.0339556621841899 1.12949273515167 0.6 16.1 16 1 abnormal fat pad morphology 0.00402690265098935 0.0339556621841899 1.12949273515167 0.6 16.1 16 1 ruffled hair 0.0084831627938493 0.0600425303126557 1.12949273515167 0.6 16.1 16 1 abnormal pericardium morphology 0.0181612252319461 0.107179235502885 1.12949273515167 0.6 16.1 16 1 brain inflammation 0.0181612252319461 0.107179235502885 1.12949273515167 0.6 16.1 16 1 decreased myocardial infarction size 0.0181612252319461 0.107179235502885 1.12949273515167 0.6 16.1 16 1 abnormal sperm mitochondrial sheath morphology 0.0181612252319461 0.107179235502885 1.12949273515167 0.6 16.1 16 1 abnormal neuron proliferation 0.0181612252319461 0.107179235502885 1.12949273515167 0.6 16.1 16 1 abnormal prostate gland morphology 0.0398545191018096 0.191597140076505 1.12949273515167 0.6 16.1 16 1 abnormal epidermis stratum spinosum morphology 0.0398545191018096 0.191597140076505 1.12949273515167 0.6 16.1 16 1 abnormal glial cell morphology 0.0398545191018096 0.191597140076505 1.12949273515167 0.6 16.1 16 1 abnormal pericyte morphology 0.0398545191018096 0.191597140076505 1.12949273515167 0.6 16.1 16 1 liver vascular congestion 0.0398545191018096 0.191597140076505 1.12949273515167 0.6 16.1 16 1 abnormal coronary vessel morphology 0.0398545191018096 0.191597140076505 1.12949273515167 0.6 16.1 16 1 decreased brown adipose tissue mass 0.0398545191018096 0.191597140076505 1.12949273515167 0.6 16.1 16 1 abnormal auchene hair morphology 0.0913121502911727 0.34053918650594 1.12949273515167 0.6 16.1 16 1 kidney hemorrhage 0.0913121502911727 0.34053918650594 1.12949273515167 0.6 16.1 16 1 jaundice 0.0913121502911727 0.34053918650594 1.12949273515167 0.6 16.1 16 1 abnormal prostate gland epithelium morphology 0.0913121502911727 0.34053918650594 1.12949273515167 0.6 16.1 16 1 abnormal tibialis anterior morphology 0.0913121502911727 0.34053918650594 1.12949273515167 0.6 16.1 16 1 rickets 0.0913121502911727 0.34053918650594 1.12949273515167 0.6 16.1 16 1 lymphedema 0.0913121502911727 0.34053918650594 1.12949273515167 0.6 16.1 16 1 abnormal submandibular gland morphology 0.0913121502911727 0.34053918650594 1.12949273515167 0.6 16.1 16 1 abnormal reproductive system development 0.0913121502911727 0.34053918650594 1.12949273515167 0.6 16.1 16 1 abnormal plasma membrane morphology 0.0913121502911727 0.34053918650594 1.12949273515167 0.6 16.1 16 1 abnormal placental transport 0.0913121502911727 0.34053918650594 1.12949273515167 0.6 16.1 16 1 vascular smooth muscle hyperplasia 0.0913121502911727 0.34053918650594 1.12949273515167 0.6 16.1 16 1 increased serotonin level 0.0913121502911727 0.34053918650594 1.12949273515167 0.6 16.1 16 1 acanthocytosis 0.0913121502911727 0.34053918650594 1.12949273515167 0.6 16.1 16 1 abnormal inferior vena cava valve morphology 0.0913121502911727 0.34053918650594 1.12949273515167 0.6 16.1 16 1 fusion of atlas and odontoid process 0.0913121502911727 0.34053918650594 1.12949273515167 0.6 16.1 16 1 increased compact bone area 0.0913121502911727 0.34053918650594 1.12949273515167 0.6 16.1 16 1 thin ventricular wall 8.22675928621348e-07 2.54211971732373e-05 1.12949273515167 0.6 16.1 16 1 oxidative stress 8.22675928621348e-07 2.54211971732373e-05 1.12949273515167 0.6 16.1 16 1 preweaning lethality, incomplete penetrance 1.30287335115929e-25 6.48179492201745e-23 1.12765167119869 0.599022004889976 16.1 16 1 eyelids open at birth 0.000207946378165912 0.00297790011073435 1.12225239710583 0.596153846153846 16.1 16 1 abnormal placenta vasculature 0.000207946378165912 0.00297790011073435 1.12225239710583 0.596153846153846 16.1 16 1 neuron degeneration 0.000423918624853709 0.00544959989314522 1.12148214837754 0.595744680851064 16.1 16 1 increased respiratory quotient 0.000423918624853709 0.00544959989314522 1.12148214837754 0.595744680851064 16.1 16 1 disheveled coat 0.000868342824280314 0.00970787764223497 1.12052850709491 0.595238095238095 16.1 16 1 abnormal pancreas morphology 0.000868342824280314 0.00970787764223497 1.12052850709491 0.595238095238095 16.1 16 1 abnormal hepatocyte morphology 8.45484146278143e-08 3.16261926897275e-06 1.11931712492508 0.594594594594595 16.1 16 1 increased insulin sensitivity 1.27727452937906e-09 6.55096988006271e-08 1.11896133435771 0.594405594405594 16.1 16 1 kidney cortex cysts 0.00371564822337173 0.0315449657188982 1.11772718582717 0.59375 16.1 16 1 failure of primitive streak formation 0.00371564822337173 0.0315449657188982 1.11772718582717 0.59375 16.1 16 1 neonatal lethality 0.00371564822337173 0.0315449657188982 1.11772718582717 0.59375 16.1 16 1 increased circulating creatinine level 2.68455851350706e-06 7.06649661624214e-05 1.11635909869642 0.593023255813954 16.1 16 1 decreased total body fat amount 3.0246527890348e-20 1.00317650836321e-17 1.11596587604806 0.592814371257485 16.1 16 1 increased circulating alkaline phosphatase level 1.4261890251574e-10 8.44677428590243e-09 1.11554838039671 0.592592592592593 16.1 16 1 decreased heart weight 5.37935027854744e-06 0.000129286317081032 1.11554838039671 0.592592592592593 16.1 16 1 decreased platelet aggregation 0.000193036151601117 0.00280805512928525 1.11554838039671 0.592592592592593 16.1 16 1 abnormal brain commissure morphology 0.00779455811597282 0.0559566040793143 1.11554838039671 0.592592592592593 16.1 16 1 cardiac hypertrophy 6.25327673694042e-07 2.00710011395346e-05 1.11412548705437 0.591836734693878 16.1 16 1 decreased circulating glucose level 5.55427761347084e-17 1.02342707877842e-14 1.1132992909201 0.591397849462366 16.1 16 1 muscular atrophy 0.000803174855241601 0.00908135205642492 1.11237920886149 0.590909090909091 16.1 16 1 decreased blood urea nitrogen level 0.000803174855241601 0.00908135205642492 1.11237920886149 0.590909090909091 16.1 16 1 abnormal abdominal fat pad morphology 0.0165837862899051 0.099402815412383 1.11237920886149 0.590909090909091 16.1 16 1 abnormal germ layer development 0.0165837862899051 0.099402815412383 1.11237920886149 0.590909090909091 16.1 16 1 abnormal female reproductive system physiology 0.0165837862899051 0.099402815412383 1.11237920886149 0.590909090909091 16.1 16 1 abnormal limb posture 0.0165837862899051 0.099402815412383 1.11237920886149 0.590909090909091 16.1 16 1 decreased circulating estradiol level 0.0165837862899051 0.099402815412383 1.11237920886149 0.590909090909091 16.1 16 1 abnormal sperm midpiece morphology 0.0165837862899051 0.099402815412383 1.11237920886149 0.590909090909091 16.1 16 1 increased bone volume 0.0165837862899051 0.099402815412383 1.11237920886149 0.590909090909091 16.1 16 1 abnormal bone structure 3.79246915908886e-12 3.14458901107785e-10 1.11193585325812 0.590673575129534 16.1 16 1 abnormal NK cell physiology 8.82939952050718e-05 0.00147403565820548 1.11097646080492 0.590163934426229 16.1 16 1 increased heart weight 4.08478279947296e-09 1.86438480985119e-07 1.11053242544888 0.589928057553957 16.1 16 1 increased susceptibility to parasitic infection 2.32104905226355e-06 6.34462584341273e-05 1.10857620301923 0.588888888888889 16.1 16 1 decreased hemoglobin content 3.80154234398391e-09 1.76753954778691e-07 1.10813117042067 0.588652482269504 16.1 16 1 abnormal embryo development 7.544467124857e-09 3.26380208227509e-07 1.10734581877615 0.588235294117647 16.1 16 1 abnormal extraembryonic tissue morphology 5.40699838809297e-07 1.75815797259886e-05 1.10734581877615 0.588235294117647 16.1 16 1 small lung 0.000363266767855878 0.0047559267633763 1.10734581877615 0.588235294117647 16.1 16 1 abnormal brown adipose tissue morphology 0.00341689604341729 0.0294611054003484 1.10734581877615 0.588235294117647 16.1 16 1 abnormal adipose tissue morphology 0.0360300149578168 0.178180242957394 1.10734581877615 0.588235294117647 16.1 16 1 abnormal interatrial septum morphology 0.0360300149578168 0.178180242957394 1.10734581877615 0.588235294117647 16.1 16 1 increased incidence of corneal inflammation 0.0360300149578168 0.178180242957394 1.10734581877615 0.588235294117647 16.1 16 1 abnormal ectoplacental cone morphology 0.0360300149578168 0.178180242957394 1.10734581877615 0.588235294117647 16.1 16 1 increased circulating magnesium level 0.0360300149578168 0.178180242957394 1.10734581877615 0.588235294117647 16.1 16 1 increased hepatoma incidence 0.0360300149578168 0.178180242957394 1.10734581877615 0.588235294117647 16.1 16 1 delayed heart development 0.0360300149578168 0.178180242957394 1.10734581877615 0.588235294117647 16.1 16 1 abnormal spermatogenesis 2.37324928993042e-11 1.6173856462197e-09 1.10493854525707 0.58695652173913 16.1 16 1 atrial septal defect 0.000741037078204045 0.00851422509021968 1.10493854525707 0.58695652173913 16.1 16 1 thrombocytosis 0.000165274849593797 0.00251450268112887 1.1035273849183 0.586206896551724 16.1 16 1 abnormal mammary gland development 0.0015191239431414 0.0151759871829889 1.10194413185529 0.585365853658537 16.1 16 1 increased tumor growth/size 0.0015191239431414 0.0151759871829889 1.10194413185529 0.585365853658537 16.1 16 1 abnormal cholesterol homeostasis 0.0015191239431414 0.0151759871829889 1.10194413185529 0.585365853658537 16.1 16 1 abnormal epidermis stratum granulosum morphology 0.00313345885325042 0.0276890902218842 1.09811793695301 0.583333333333333 16.1 16 1 muscular ventricular septal defect 0.000152504618839652 0.00234894885054882 1.09811793695301 0.583333333333333 16.1 16 1 abnormal intestinal epithelium morphology 0.000682219875442993 0.00798598560077386 1.09811793695301 0.583333333333333 16.1 16 1 decreased metastatic potential 0.0150871311282649 0.0919005846913794 1.09811793695301 0.583333333333333 16.1 16 1 abnormal startle reflex 0.0150871311282649 0.0919005846913794 1.09811793695301 0.583333333333333 16.1 16 1 abnormal primitive streak formation 0.0150871311282649 0.0919005846913794 1.09811793695301 0.583333333333333 16.1 16 1 prolonged QT interval 0.0150871311282649 0.0919005846913794 1.09811793695301 0.583333333333333 16.1 16 1 amyloidosis 0.0810087726760759 0.311188399555401 1.09811793695301 0.583333333333333 16.1 16 1 abnormal mating frequency 0.0810087726760759 0.311188399555401 1.09811793695301 0.583333333333333 16.1 16 1 increased growth rate 0.0810087726760759 0.311188399555401 1.09811793695301 0.583333333333333 16.1 16 1 increased circulating parathyroid hormone level 0.0810087726760759 0.311188399555401 1.09811793695301 0.583333333333333 16.1 16 1 decreased circulating ketone body level 0.0810087726760759 0.311188399555401 1.09811793695301 0.583333333333333 16.1 16 1 absent ovary 0.0810087726760759 0.311188399555401 1.09811793695301 0.583333333333333 16.1 16 1 increased osteosarcoma incidence 0.0810087726760759 0.311188399555401 1.09811793695301 0.583333333333333 16.1 16 1 abnormal nucleotide metabolism 0.0810087726760759 0.311188399555401 1.09811793695301 0.583333333333333 16.1 16 1 decreased renal glomerular filtration rate 0.0810087726760759 0.311188399555401 1.09811793695301 0.583333333333333 16.1 16 1 abnormal thymus corticomedullary boundary morphology 0.0810087726760759 0.311188399555401 1.09811793695301 0.583333333333333 16.1 16 1 abnormal colon goblet cell morphology 0.0810087726760759 0.311188399555401 1.09811793695301 0.583333333333333 16.1 16 1 abnormal vitelline vein connection 0.0810087726760759 0.311188399555401 1.09811793695301 0.583333333333333 16.1 16 1 decreased hematocrit 5.19020950604401e-09 2.34739020841536e-07 1.09596897817228 0.582191780821918 16.1 16 1 enlarged heart 2.03471705427247e-13 2.10889944687615e-11 1.09541321297037 0.581896551724138 16.1 16 1 premature death 4.4907431648345e-46 7.44714908168388e-43 1.09538494059424 0.581881533101045 16.1 16 1 abnormal embryo turning 0.00030869281777602 0.00416191536161437 1.09526568257132 0.581818181818182 16.1 16 1 abnormal angiogenesis 3.19912536657872e-05 0.00063157336106068 1.0938780993586 0.581081081081081 16.1 16 1 hypoglycemia 3.40647055706375e-06 8.55918738454149e-05 1.09305748563065 0.580645161290323 16.1 16 1 abnormal immune system physiology 8.65019214742366e-08 3.21154521891289e-06 1.09305748563065 0.580645161290323 16.1 16 1 osteopetrosis 0.00651469525232033 0.0471084431399617 1.09305748563065 0.580645161290323 16.1 16 1 increased lung adenoma incidence 0.00651469525232033 0.0471084431399617 1.09305748563065 0.580645161290323 16.1 16 1 abnormal capillary morphology 0.00651469525232033 0.0471084431399617 1.09305748563065 0.580645161290323 16.1 16 1 abnormal neural tube morphology 1.05162488125412e-09 5.68677585243394e-08 1.09230778913845 0.580246913580247 16.1 16 1 increased circulating chloride level 0.000626878730976853 0.00749692713127366 1.09184297731328 0.58 16.1 16 1 microcephaly 6.42412278998097e-05 0.00112535249578012 1.09129732864896 0.579710144927536 16.1 16 1 incomplete embryo turning 0.000283832950260501 0.00387931024051096 1.08986141111126 0.578947368421053 16.1 16 1 persistence of hyaloid vascular system 0.00286692524058172 0.0254695590569537 1.08986141111126 0.578947368421053 16.1 16 1 decreased total retina thickness 0.00286692524058172 0.0254695590569537 1.08986141111126 0.578947368421053 16.1 16 1 small superior vagus ganglion 0.0324618542628936 0.162800125965621 1.08986141111126 0.578947368421053 16.1 16 1 unresponsive to tactile stimuli 0.0324618542628936 0.162800125965621 1.08986141111126 0.578947368421053 16.1 16 1 abnormal digestive system development 0.0324618542628936 0.162800125965621 1.08986141111126 0.578947368421053 16.1 16 1 oliguria 0.0324618542628936 0.162800125965621 1.08986141111126 0.578947368421053 16.1 16 1 abnormal cochlear inner hair cell morphology 0.0324618542628936 0.162800125965621 1.08986141111126 0.578947368421053 16.1 16 1 decreased liver regeneration 0.0324618542628936 0.162800125965621 1.08986141111126 0.578947368421053 16.1 16 1 azoospermia 1.92180236278549e-09 9.46630371768101e-08 1.08923827708547 0.578616352201258 16.1 16 1 abnormal lipid level 1.35747652169393e-05 0.000293628073714231 1.08866769653173 0.578313253012048 16.1 16 1 abnormal renal glomerulus morphology 6.76270106431281e-07 2.15669473044591e-05 1.0880434604672 0.577981651376147 16.1 16 1 abnormal myocardial fiber morphology 2.89866510453778e-06 7.58992573425025e-05 1.08679713347927 0.577319587628866 16.1 16 1 abnormal tooth development 0.00593389452757669 0.0431595398752837 1.08385666504453 0.575757575757576 16.1 16 1 increased osteoblast cell number 0.00593389452757669 0.0431595398752837 1.08385666504453 0.575757575757576 16.1 16 1 prenatal lethality, incomplete penetrance 2.54795497581107e-16 4.22535866822002e-14 1.08366901672995 0.575657894736842 16.1 16 1 abnormal eye morphology 2.93082689764492e-08 1.17587611417609e-06 1.08344626873062 0.575539568345324 16.1 16 1 astrocytosis 5.43434665621338e-05 0.000979560674444259 1.0830752254879 0.575342465753425 16.1 16 1 abnormal retinal pigmentation 1.14987341805562e-05 0.000257685597064266 1.08188959305716 0.574712643678161 16.1 16 1 impaired limb coordination 0.000526763471701979 0.00651902555153569 1.08068749350931 0.574074074074074 16.1 16 1 decreased tumor growth/size 0.000526763471701979 0.00651902555153569 1.08068749350931 0.574074074074074 16.1 16 1 axon degeneration 0.000526763471701979 0.00651902555153569 1.08068749350931 0.574074074074074 16.1 16 1 abnormal nervous system physiology 5.29073671843336e-07 1.7316720509346e-05 1.08038435536247 0.573913043478261 16.1 16 1 perinatal lethality, complete penetrance 1.24732225814854e-11 9.12562975630732e-10 1.07823250147499 0.572769953051643 16.1 16 1 decreased susceptibility to hepatic steatosis 0.000218831574940635 0.00310167260777681 1.07570736681111 0.571428571428571 16.1 16 1 abnormal seminal vesicle morphology 0.00048188983356733 0.00613146271610606 1.07570736681111 0.571428571428571 16.1 16 1 abnormal ovulation 0.0123924534377236 0.0792448018671914 1.07570736681111 0.571428571428571 16.1 16 1 increased triglyceride level 0.0123924534377236 0.0792448018671914 1.07570736681111 0.571428571428571 16.1 16 1 abnormal blood flow velocity 0.0717748614264653 0.280723219808699 1.07570736681111 0.571428571428571 16.1 16 1 translucent skin 0.0717748614264653 0.280723219808699 1.07570736681111 0.571428571428571 16.1 16 1 irregularly shaped pupil 0.0717748614264653 0.280723219808699 1.07570736681111 0.571428571428571 16.1 16 1 absent visceral yolk sac blood islands 0.0717748614264653 0.280723219808699 1.07570736681111 0.571428571428571 16.1 16 1 abnormal vascular endothelial cell migration 0.0717748614264653 0.280723219808699 1.07570736681111 0.571428571428571 16.1 16 1 abnormal glucose tolerance 0.0717748614264653 0.280723219808699 1.07570736681111 0.571428571428571 16.1 16 1 abnormal vitelline vein topology 0.0717748614264653 0.280723219808699 1.07570736681111 0.571428571428571 16.1 16 1 spina bifida 0.00238683210162287 0.0223625041536229 1.07570736681111 0.571428571428571 16.1 16 1 thick pulmonary interalveolar septum 0.00539494442429992 0.0406664371377153 1.07570736681111 0.571428571428571 16.1 16 1 increased carcinoma incidence 0.00539494442429992 0.0406664371377153 1.07570736681111 0.571428571428571 16.1 16 1 increased circulating serum albumin level 0.00539494442429992 0.0406664371377153 1.07570736681111 0.571428571428571 16.1 16 1 trunk curl 0.0291823303225208 0.149210784537041 1.07570736681111 0.571428571428571 16.1 16 1 abnormal clavicle morphology 0.0291823303225208 0.149210784537041 1.07570736681111 0.571428571428571 16.1 16 1 abnormal tumor vascularization 0.0291823303225208 0.149210784537041 1.07570736681111 0.571428571428571 16.1 16 1 increased muscle cell glucose uptake 0.0291823303225208 0.149210784537041 1.07570736681111 0.571428571428571 16.1 16 1 abnormal placenta labyrinth morphology 4.19479267417502e-05 0.000799582128506542 1.07230322957437 0.569620253164557 16.1 16 1 increased susceptibility to bacterial infection induced morbidity/mortality 9.14623155731371e-05 0.00149276768954089 1.07197227178746 0.569444444444444 16.1 16 1 abnormal spermiogenesis 0.000440329643140553 0.00561702557595962 1.07107069712658 0.568965517241379 16.1 16 1 abnormal dendritic spine morphology 0.000974367227818134 0.010772171018656 1.07043429148361 0.568627450980392 16.1 16 1 decreased birth weight 8.16385510737445e-06 0.000186308161280678 1.07004574909106 0.568421052631579 16.1 16 1 decreased sensitivity to induced morbidity/mortality 0.00217306512197498 0.020911023175678 1.06959539313605 0.568181818181818 16.1 16 1 abnormal chromosome morphology 0.00489759177470006 0.0390422299922266 1.06843907379212 0.567567567567568 16.1 16 1 decreased white adipose tissue amount 0.000182980003974295 0.00270759019551855 1.06767969989461 0.567164179104478 16.1 16 1 intracranial hemorrhage 0.000401939247519966 0.00522101241882985 1.06674313875435 0.566666666666667 16.1 16 1 abnormal lactation 0.0112019573165367 0.0739121188988995 1.06674313875435 0.566666666666667 16.1 16 1 disorganized myocardium 0.0112019573165367 0.0739121188988995 1.06674313875435 0.566666666666667 16.1 16 1 hemorrhage 4.95298681567298e-12 3.91128720761477e-10 1.06540804095867 0.565957446808511 16.1 16 1 increased blood urea nitrogen level 5.8060777281836e-08 2.23916563548166e-06 1.06457935956824 0.56551724137931 16.1 16 1 abnormal testis morphology 1.3478539606893e-06 4.01293896853759e-05 1.06401489543273 0.565217391304348 16.1 16 1 perimembraneous ventricular septal defect 0.000167094836074101 0.00253444149228248 1.06401489543273 0.565217391304348 16.1 16 1 fragile skeleton 0.0261957968149838 0.136608059910424 1.06401489543273 0.565217391304348 16.1 16 1 abnormal innervation pattern to muscle 0.0261957968149838 0.136608059910424 1.06401489543273 0.565217391304348 16.1 16 1 abnormal postnatal growth 0.0261957968149838 0.136608059910424 1.06401489543273 0.565217391304348 16.1 16 1 dilated heart 0.0261957968149838 0.136608059910424 1.06401489543273 0.565217391304348 16.1 16 1 abnormal behavior 7.96221258653529e-14 8.73213203681335e-12 1.06313165119192 0.564748201438849 16.1 16 1 pericardial effusion 0.000366557669287474 0.00478641576038106 1.06269477769646 0.564516129032258 16.1 16 1 abnormal leukocyte adhesion 0.00444060702627017 0.0365253363684068 1.06191624672379 0.564102564102564 16.1 16 1 failure of heart looping 0.00444060702627017 0.0365253363684068 1.06191624672379 0.564102564102564 16.1 16 1 atelectasis 0.000152467845960236 0.00234894885054882 1.06055655882786 0.563380281690141 16.1 16 1 abnormal coat/hair pigmentation 2.43048741161668e-06 6.57156243086576e-05 1.05889943920469 0.5625 16.1 16 1 polydipsia 0.0101134700038257 0.0692084088982569 1.05889943920469 0.5625 16.1 16 1 blepharitis 0.0635786344492063 0.253042965107841 1.05889943920469 0.5625 16.1 16 1 dystonia 0.0635786344492063 0.253042965107841 1.05889943920469 0.5625 16.1 16 1 abnormal Langerhans cell physiology 0.0635786344492063 0.253042965107841 1.05889943920469 0.5625 16.1 16 1 kidney degeneration 0.0635786344492063 0.253042965107841 1.05889943920469 0.5625 16.1 16 1 impaired somite development 0.0635786344492063 0.253042965107841 1.05889943920469 0.5625 16.1 16 1 decreased liver cholesterol level 0.0635786344492063 0.253042965107841 1.05889943920469 0.5625 16.1 16 1 abnormal thoracic cage shape 0.0635786344492063 0.253042965107841 1.05889943920469 0.5625 16.1 16 1 abnormal muscle physiology 2.68106811288808e-05 0.000542207880553585 1.05757746737048 0.561797752808989 16.1 16 1 small testis 2.143942498097e-13 2.17675794449644e-11 1.05719428712868 0.561594202898551 16.1 16 1 impaired natural killer cell mediated cytotoxicity 0.000735402644200064 0.00846904665485027 1.05683530774425 0.56140350877193 16.1 16 1 abnormal developmental patterning 5.81918493604529e-05 0.00103394446631519 1.05602979302798 0.560975609756098 16.1 16 1 liver fibrosis 0.00402215097649978 0.0339556621841899 1.05602979302798 0.560975609756098 16.1 16 1 abnormal skin morphology 0.000304132736633276 0.00412278028542384 1.05533412122757 0.560606060606061 16.1 16 1 abnormal glucose homeostasis 2.93553966801509e-09 1.40426056234376e-07 1.05502068668013 0.56043956043956 16.1 16 1 kidney inflammation 0.00162941900369651 0.0162452095057918 1.05419321947489 0.56 16.1 16 1 diaphragmatic hernia 0.0234921817357029 0.129329822428059 1.05419321947489 0.56 16.1 16 1 abnormal cochlear outer hair cell morphology 0.0234921817357029 0.129329822428059 1.05419321947489 0.56 16.1 16 1 increased circulating triglyceride level 1.43190267391461e-07 5.16211290052548e-06 1.05159668445155 0.558620689655172 16.1 16 1 abnormal blood vessel morphology 1.43190267391461e-07 5.16211290052548e-06 1.05159668445155 0.558620689655172 16.1 16 1 abnormal left-right axis patterning 0.00364002838218292 0.0310619917690566 1.05069091642016 0.558139534883721 16.1 16 1 decreased bone mineral content 3.7730292818243e-10 2.10908097495234e-08 1.04984901664739 0.557692307692308 16.1 16 1 abnormal skin condition 0.00147783235514154 0.0148529615491498 1.04984901664739 0.557692307692308 16.1 16 1 kinked neural tube 0.00147783235514154 0.0148529615491498 1.04984901664739 0.557692307692308 16.1 16 1 abnormal somite development 0.000104993184772976 0.00168497127175986 1.04847426891716 0.556962025316456 16.1 16 1 small kidney 4.40299771692855e-05 0.000829731577337861 1.04820348527333 0.556818181818182 16.1 16 1 abnormal vitelline vasculature morphology 3.31859545463961e-06 8.38071694763049e-05 1.047645435503 0.556521739130435 16.1 16 1 gliosis 0.000551215287221019 0.00677110136771499 1.04582660662192 0.555555555555556 16.1 16 1 abnormal osteoblast physiology 0.00133946630166564 0.0138830101058053 1.04582660662192 0.555555555555556 16.1 16 1 reduced long term depression 0.0082218013881118 0.0587693418187589 1.04582660662192 0.555555555555556 16.1 16 1 thin epidermis 0.0210542873759172 0.120170661664752 1.04582660662192 0.555555555555556 16.1 16 1 increased brain weight 0.0210542873759172 0.120170661664752 1.04582660662192 0.555555555555556 16.1 16 1 abnormal type II pneumocyte morphology 0.0210542873759172 0.120170661664752 1.04582660662192 0.555555555555556 16.1 16 1 abnormal mitral valve morphology 0.0563337870724192 0.228597545420298 1.04582660662192 0.555555555555556 16.1 16 1 abnormal mammary gland morphology 0.0563337870724192 0.228597545420298 1.04582660662192 0.555555555555556 16.1 16 1 abnormal phrenic nerve morphology 0.0563337870724192 0.228597545420298 1.04582660662192 0.555555555555556 16.1 16 1 abnormal iron level 0.0563337870724192 0.228597545420298 1.04582660662192 0.555555555555556 16.1 16 1 eye inflammation 0.0563337870724192 0.228597545420298 1.04582660662192 0.555555555555556 16.1 16 1 abnormal white adipose tissue morphology 0.0563337870724192 0.228597545420298 1.04582660662192 0.555555555555556 16.1 16 1 increased circulating glycerol level 0.0563337870724192 0.228597545420298 1.04582660662192 0.555555555555556 16.1 16 1 abnormal eye anterior chamber morphology 0.0563337870724192 0.228597545420298 1.04582660662192 0.555555555555556 16.1 16 1 darkened coat color 0.0563337870724192 0.228597545420298 1.04582660662192 0.555555555555556 16.1 16 1 jerky movement 0.0563337870724192 0.228597545420298 1.04582660662192 0.555555555555556 16.1 16 1 abnormal glycogen homeostasis 0.0563337870724192 0.228597545420298 1.04582660662192 0.555555555555556 16.1 16 1 decreased lactate dehydrogenase level 0.0563337870724192 0.228597545420298 1.04582660662192 0.555555555555556 16.1 16 1 abnormal pregnancy 0.0563337870724192 0.228597545420298 1.04582660662192 0.555555555555556 16.1 16 1 small thoracic cage 0.0563337870724192 0.228597545420298 1.04582660662192 0.555555555555556 16.1 16 1 increased gastrointestinal tumor incidence 0.0563337870724192 0.228597545420298 1.04582660662192 0.555555555555556 16.1 16 1 abnormal head movements 0.166538091015214 0.46942039818736 1.04582660662192 0.555555555555556 16.1 16 1 abnormal sympathetic neuron morphology 0.166538091015214 0.46942039818736 1.04582660662192 0.555555555555556 16.1 16 1 psoriasis 0.166538091015214 0.46942039818736 1.04582660662192 0.555555555555556 16.1 16 1 abnormal kindling response 0.166538091015214 0.46942039818736 1.04582660662192 0.555555555555556 16.1 16 1 multifocal hepatic necrosis 0.166538091015214 0.46942039818736 1.04582660662192 0.555555555555556 16.1 16 1 abnormal ion homeostasis 0.166538091015214 0.46942039818736 1.04582660662192 0.555555555555556 16.1 16 1 abnormal vomeronasal organ morphology 0.166538091015214 0.46942039818736 1.04582660662192 0.555555555555556 16.1 16 1 abnormal thymus lobule morphology 0.166538091015214 0.46942039818736 1.04582660662192 0.555555555555556 16.1 16 1 decreased circulating bicarbonate level 0.166538091015214 0.46942039818736 1.04582660662192 0.555555555555556 16.1 16 1 pancreas cysts 0.166538091015214 0.46942039818736 1.04582660662192 0.555555555555556 16.1 16 1 decreased fear-related response 0.166538091015214 0.46942039818736 1.04582660662192 0.555555555555556 16.1 16 1 enhanced conditioned place preference behavior 0.166538091015214 0.46942039818736 1.04582660662192 0.555555555555556 16.1 16 1 multiflagellated sperm 0.166538091015214 0.46942039818736 1.04582660662192 0.555555555555556 16.1 16 1 abnormal cerebellar layer morphology 0.166538091015214 0.46942039818736 1.04582660662192 0.555555555555556 16.1 16 1 abnormal telomere morphology 0.166538091015214 0.46942039818736 1.04582660662192 0.555555555555556 16.1 16 1 abnormal ventricle myocardium morphology 0.166538091015214 0.46942039818736 1.04582660662192 0.555555555555556 16.1 16 1 prolonged RR interval 0.166538091015214 0.46942039818736 1.04582660662192 0.555555555555556 16.1 16 1 shortened ST segment 0.166538091015214 0.46942039818736 1.04582660662192 0.555555555555556 16.1 16 1 iris coloboma 0.166538091015214 0.46942039818736 1.04582660662192 0.555555555555556 16.1 16 1 abnormal pulmonary alveolar system morphology 0.166538091015214 0.46942039818736 1.04582660662192 0.555555555555556 16.1 16 1 abnormal oxidative phosphorylation 0.166538091015214 0.46942039818736 1.04582660662192 0.555555555555556 16.1 16 1 increased core body temperature 0.166538091015214 0.46942039818736 1.04582660662192 0.555555555555556 16.1 16 1 decreased pancreatic beta cell proliferation 0.166538091015214 0.46942039818736 1.04582660662192 0.555555555555556 16.1 16 1 decreased bone trabecular spacing 0.166538091015214 0.46942039818736 1.04582660662192 0.555555555555556 16.1 16 1 increased myeloid cell number 0.166538091015214 0.46942039818736 1.04582660662192 0.555555555555556 16.1 16 1 abnormal ductus venosus valve topology 0.166538091015214 0.46942039818736 1.04582660662192 0.555555555555556 16.1 16 1 symmetric azygos veins 0.166538091015214 0.46942039818736 1.04582660662192 0.555555555555556 16.1 16 1 enhanced leukocyte tethering or rolling 0.166538091015214 0.46942039818736 1.04582660662192 0.555555555555556 16.1 16 1 albuminuria 0.00329186275126993 0.0288401838545375 1.04582660662192 0.555555555555556 16.1 16 1 small placenta 0.00329186275126993 0.0288401838545375 1.04582660662192 0.555555555555556 16.1 16 1 cardiomyopathy 0.00329186275126993 0.0288401838545375 1.04582660662192 0.555555555555556 16.1 16 1 abnormal seminiferous tubule morphology 2.1256802865276e-07 7.4473657925879e-06 1.04439396743476 0.554794520547945 16.1 16 1 abnormal heart morphology 8.57371103800064e-11 5.39926739418395e-09 1.04311017387744 0.554112554112554 16.1 16 1 small seminiferous tubules 0.00020777671632533 0.00297790011073435 1.04300004822564 0.554054054054054 16.1 16 1 abnormal liver morphology 1.25840490728559e-08 5.30556306249646e-07 1.04115252122919 0.553072625698324 16.1 16 1 dermatitis 0.00109856941473485 0.0119331503019779 1.03861400933487 0.551724137931034 16.1 16 1 cochlear ganglion degeneration 0.00109856941473485 0.0119331503019779 1.03861400933487 0.551724137931034 16.1 16 1 increased susceptibility to induced arthritis 0.0188618201228482 0.110788140627119 1.03861400933487 0.551724137931034 16.1 16 1 abnormal epidermis stratum corneum morphology 0.00268766848073776 0.0245342214526061 1.03728924656786 0.551020408163265 16.1 16 1 abnormal craniofacial development 0.00268766848073776 0.0245342214526061 1.03728924656786 0.551020408163265 16.1 16 1 abnormal retinal pigment epithelium morphology 0.000155354052730358 0.0023854518899183 1.0353683405557 0.55 16.1 16 1 abnormal eating behavior 0.00099420086272821 0.0109670716010484 1.0353683405557 0.55 16.1 16 1 decreased circulating phosphate level 0.00666822089588024 0.0481486196763486 1.0353683405557 0.55 16.1 16 1 small gonad 0.049940400856274 0.219288167925828 1.0353683405557 0.55 16.1 16 1 abnormal hair texture 0.049940400856274 0.219288167925828 1.0353683405557 0.55 16.1 16 1 spleen atrophy 0.049940400856274 0.219288167925828 1.0353683405557 0.55 16.1 16 1 distended abdomen 0.00242687333954845 0.022652335580213 1.03352276419107 0.549019607843137 16.1 16 1 failure of chorioallantoic fusion 0.00242687333954845 0.022652335580213 1.03352276419107 0.549019607843137 16.1 16 1 sparse hair 0.000140898979233605 0.00221826715723792 1.03307262361433 0.548780487804878 16.1 16 1 lethargy 5.36586171704813e-05 0.000970733165175071 1.03233206976228 0.548387096774194 16.1 16 1 increased eosinophil cell number 0.000899397572011441 0.00996548534689738 1.03233206976228 0.548387096774194 16.1 16 1 abnormal object recognition memory 0.0168936326802281 0.100895345239057 1.03233206976228 0.548387096774194 16.1 16 1 abnormal podocyte morphology 0.0168936326802281 0.100895345239057 1.03233206976228 0.548387096774194 16.1 16 1 decreased body weight 4.74400384861712e-49 1.18007095734351e-45 1.0309586354777 0.547657512116317 16.1 16 1 abnormal placenta development 0.00219058906950236 0.0209984212346324 1.03004054463517 0.547169811320755 16.1 16 1 enlarged kidney 0.00219058906950236 0.0209984212346324 1.03004054463517 0.547169811320755 16.1 16 1 decreased circulating LDL cholesterol level 0.000813354829362356 0.00917560153305605 1.02948556589345 0.546875 16.1 16 1 delayed bone ossification 0.000305574347125022 0.00413106624170377 1.02909338091597 0.546666666666667 16.1 16 1 edema 6.27722210582217e-08 2.38390686843246e-06 1.02880152232807 0.546511627906977 16.1 16 1 cataract 5.91271340745758e-06 0.000139411133659249 1.02681157741061 0.545454545454545 16.1 16 1 abnormal neuron morphology 4.00453013527682e-05 0.000771716195187632 1.02681157741061 0.545454545454545 16.1 16 1 dextrocardia 0.0151289605753246 0.0919005846913794 1.02681157741061 0.545454545454545 16.1 16 1 abnormal epidermis stratum basale morphology 0.0151289605753246 0.0919005846913794 1.02681157741061 0.545454545454545 16.1 16 1 decreased brown adipose tissue amount 0.0151289605753246 0.0919005846913794 1.02681157741061 0.545454545454545 16.1 16 1 abnormal locomotor coordination 0.0151289605753246 0.0919005846913794 1.02681157741061 0.545454545454545 16.1 16 1 diarrhea 0.0151289605753246 0.0919005846913794 1.02681157741061 0.545454545454545 16.1 16 1 abnormal tail movements 0.0443005831616596 0.199633515606211 1.02681157741061 0.545454545454545 16.1 16 1 prolonged PR interval 0.0443005831616596 0.199633515606211 1.02681157741061 0.545454545454545 16.1 16 1 abnormal circulating lipid level 0.0443005831616596 0.199633515606211 1.02681157741061 0.545454545454545 16.1 16 1 abnormal occipital bone morphology 0.0443005831616596 0.199633515606211 1.02681157741061 0.545454545454545 16.1 16 1 decreased susceptibility to viral infection induced morbidity/mortality 0.0443005831616596 0.199633515606211 1.02681157741061 0.545454545454545 16.1 16 1 increased mammary gland tumor incidence 0.0443005831616596 0.199633515606211 1.02681157741061 0.545454545454545 16.1 16 1 embryonic lethality before implantation, incomplete penetrance 0.0443005831616596 0.199633515606211 1.02681157741061 0.545454545454545 16.1 16 1 abnormal thrombopoiesis 0.143500507115943 0.41798303448584 1.02681157741061 0.545454545454545 16.1 16 1 abnormal stomach epithelium morphology 0.143500507115943 0.41798303448584 1.02681157741061 0.545454545454545 16.1 16 1 abnormal enteric ganglia morphology 0.143500507115943 0.41798303448584 1.02681157741061 0.545454545454545 16.1 16 1 abnormal proximal-distal axis patterning 0.143500507115943 0.41798303448584 1.02681157741061 0.545454545454545 16.1 16 1 abnormal fear/anxiety-related behavior 0.143500507115943 0.41798303448584 1.02681157741061 0.545454545454545 16.1 16 1 abnormal bronchiole morphology 0.143500507115943 0.41798303448584 1.02681157741061 0.545454545454545 16.1 16 1 decreased post-tetanic potentiation 0.143500507115943 0.41798303448584 1.02681157741061 0.545454545454545 16.1 16 1 pulmonary hypertension 0.143500507115943 0.41798303448584 1.02681157741061 0.545454545454545 16.1 16 1 abnormal radial glial cell morphology 0.143500507115943 0.41798303448584 1.02681157741061 0.545454545454545 16.1 16 1 abnormal hair medulla 0.143500507115943 0.41798303448584 1.02681157741061 0.545454545454545 16.1 16 1 pharyngeal arch hypoplasia 0.143500507115943 0.41798303448584 1.02681157741061 0.545454545454545 16.1 16 1 abnormal dorsal-ventral polarity of the somites 0.143500507115943 0.41798303448584 1.02681157741061 0.545454545454545 16.1 16 1 palatal shelf hypoplasia 0.143500507115943 0.41798303448584 1.02681157741061 0.545454545454545 16.1 16 1 decreased palatine bone horizontal plate size 0.143500507115943 0.41798303448584 1.02681157741061 0.545454545454545 16.1 16 1 decreased core body temperature 0.143500507115943 0.41798303448584 1.02681157741061 0.545454545454545 16.1 16 1 abnormal brain ependyma motile cilium morphology 0.143500507115943 0.41798303448584 1.02681157741061 0.545454545454545 16.1 16 1 hypolactation 0.143500507115943 0.41798303448584 1.02681157741061 0.545454545454545 16.1 16 1 abnormal pulmonary alveolus morphology 3.63054572224938e-05 0.000705545506569948 1.02511716886703 0.544554455445545 16.1 16 1 decreased insulin secretion 9.50516629858565e-05 0.00154536608939424 1.02491007448948 0.544444444444444 16.1 16 1 abnormal myocardium layer morphology 0.00025035081533903 0.00348878237062094 1.02464530825995 0.544303797468354 16.1 16 1 abnormal locomotor behavior 8.60892785417967e-05 0.0014469397322481 1.0230912456084 0.543478260869565 16.1 16 1 abnormal allantois morphology 0.004858230382574 0.0389206057219092 1.0230912456084 0.543478260869565 16.1 16 1 ovary cysts 0.0135480810750761 0.0861914365070381 1.02192199847056 0.542857142857143 16.1 16 1 abnormal embryonic epiblast morphology 0.0135480810750761 0.0861914365070381 1.02192199847056 0.542857142857143 16.1 16 1 male infertility 1.18057216612834e-19 3.6708415790553e-17 1.02170814014714 0.542743538767396 16.1 16 1 abnormal forebrain development 0.000542518143913602 0.00668076179695587 1.01968094145637 0.541666666666667 16.1 16 1 abnormal digestive system morphology 0.039324219899288 0.191597140076505 1.01968094145637 0.541666666666667 16.1 16 1 decreased body height 0.039324219899288 0.191597140076505 1.01968094145637 0.541666666666667 16.1 16 1 ocular hypertelorism 0.039324219899288 0.191597140076505 1.01968094145637 0.541666666666667 16.1 16 1 blindness 0.039324219899288 0.191597140076505 1.01968094145637 0.541666666666667 16.1 16 1 abnormal tumor morphology 0.039324219899288 0.191597140076505 1.01968094145637 0.541666666666667 16.1 16 1 abnormal inner cell mass apoptosis 0.039324219899288 0.191597140076505 1.01968094145637 0.541666666666667 16.1 16 1 abnormal lung saccule morphology 0.039324219899288 0.191597140076505 1.01968094145637 0.541666666666667 16.1 16 1 cardiac fibrosis 0.000185327648514134 0.00271913900131325 1.01875815327406 0.541176470588235 16.1 16 1 polydactyly 6.38830594681176e-05 0.00112303258252256 1.01808018644623 0.540816326530612 16.1 16 1 abnormal intestine morphology 0.000490021562652345 0.00618745501064827 1.01756102265916 0.540540540540541 16.1 16 1 increased brown adipose tissue amount 0.0121326362274197 0.0778836970727909 1.01756102265916 0.540540540540541 16.1 16 1 malocclusion 0.0121326362274197 0.0778836970727909 1.01756102265916 0.540540540540541 16.1 16 1 increased erythroid progenitor cell number 0.0121326362274197 0.0778836970727909 1.01756102265916 0.540540540540541 16.1 16 1 abnormal calcium ion homeostasis 0.0121326362274197 0.0778836970727909 1.01756102265916 0.540540540540541 16.1 16 1 decreased body length 3.95580564617636e-11 2.65947744455776e-09 1.01681827738715 0.54014598540146 16.1 16 1 enlarged liver 5.7815174570972e-05 0.00103093366842504 1.0165434616365 0.54 16.1 16 1 abnormal circulating protein level 0.00392996134509053 0.0333075940235527 1.0165434616365 0.54 16.1 16 1 increased bone mineral density 2.00756623994272e-05 0.000417892972540379 1.01621027793882 0.539823008849557 16.1 16 1 impaired balance 5.23153486488109e-05 0.00094988634864173 1.0150670005448 0.53921568627451 16.1 16 1 abnormal skeleton morphology 1.81773462952117e-05 0.000383187702621518 1.01490651564353 0.539130434782609 16.1 16 1 limb grasping 8.82026199204736e-08 3.25042988225449e-06 1.01364732641816 0.538461538461538 16.1 16 1 abnormal snout morphology 0.00353408782135652 0.0302097713251696 1.01364732641816 0.538461538461538 16.1 16 1 absent corpus luteum 0.00353408782135652 0.0302097713251696 1.01364732641816 0.538461538461538 16.1 16 1 increased susceptibility to injury 0.00353408782135652 0.0302097713251696 1.01364732641816 0.538461538461538 16.1 16 1 decreased body temperature 0.00353408782135652 0.0302097713251696 1.01364732641816 0.538461538461538 16.1 16 1 acanthosis 0.0108657599009499 0.0722689244749005 1.01364732641816 0.538461538461538 16.1 16 1 abnormal Mullerian duct morphology 0.0349306607868983 0.17430294625358 1.01364732641816 0.538461538461538 16.1 16 1 absent common myeloid progenitor cells 0.124361584200973 0.370700348352211 1.01364732641816 0.538461538461538 16.1 16 1 absent myocardial trabeculae 0.124361584200973 0.370700348352211 1.01364732641816 0.538461538461538 16.1 16 1 abnormal mast cell morphology 0.124361584200973 0.370700348352211 1.01364732641816 0.538461538461538 16.1 16 1 short hair 0.124361584200973 0.370700348352211 1.01364732641816 0.538461538461538 16.1 16 1 excessive scratching 0.124361584200973 0.370700348352211 1.01364732641816 0.538461538461538 16.1 16 1 abnormal digestion 0.124361584200973 0.370700348352211 1.01364732641816 0.538461538461538 16.1 16 1 increased pituitary adenoma incidence 0.124361584200973 0.370700348352211 1.01364732641816 0.538461538461538 16.1 16 1 abnormal bile duct development 0.124361584200973 0.370700348352211 1.01364732641816 0.538461538461538 16.1 16 1 abnormal telomere length 0.124361584200973 0.370700348352211 1.01364732641816 0.538461538461538 16.1 16 1 increased cochlear inner hair cell number 0.124361584200973 0.370700348352211 1.01364732641816 0.538461538461538 16.1 16 1 increased circulating thyroxine level 0.124361584200973 0.370700348352211 1.01364732641816 0.538461538461538 16.1 16 1 abnormal hair follicle inner root sheath morphology 0.124361584200973 0.370700348352211 1.01364732641816 0.538461538461538 16.1 16 1 decreased body size 5.8349481369452e-29 3.6286083726628e-26 1.01201416746046 0.537593984962406 16.1 16 1 abnormal posture 0.000360752458370732 0.00473547092452346 1.0118372419067 0.5375 16.1 16 1 impaired righting response 0.000111882383699398 0.00178402198366829 1.01059876303044 0.536842105263158 16.1 16 1 Leydig cell hyperplasia 0.00973209132884705 0.067339574911007 1.01011545420068 0.536585365853659 16.1 16 1 hemopericardium 0.00973209132884705 0.067339574911007 1.01011545420068 0.536585365853659 16.1 16 1 abnormal circulating cholesterol level 0.031048711150756 0.156979002007125 1.00847565638542 0.535714285714286 16.1 16 1 straub tail 0.031048711150756 0.156979002007125 1.00847565638542 0.535714285714286 16.1 16 1 failure of blastocyst to hatch from the zona pellucida 0.031048711150756 0.156979002007125 1.00847565638542 0.535714285714286 16.1 16 1 premature aging 0.031048711150756 0.156979002007125 1.00847565638542 0.535714285714286 16.1 16 1 abnormal hormone level 0.031048711150756 0.156979002007125 1.00847565638542 0.535714285714286 16.1 16 1 corneal vascularization 0.031048711150756 0.156979002007125 1.00847565638542 0.535714285714286 16.1 16 1 abnormal mitotic spindle morphology 0.031048711150756 0.156979002007125 1.00847565638542 0.535714285714286 16.1 16 1 prolonged QRS complex duration 0.031048711150756 0.156979002007125 1.00847565638542 0.535714285714286 16.1 16 1 abnormal ovary morphology 0.000863045608217003 0.00969221648054083 1.00752873088647 0.535211267605634 16.1 16 1 decreased liver weight 0.000863045608217003 0.00969221648054083 1.00752873088647 0.535211267605634 16.1 16 1 abnormal male reproductive system morphology 0.00871772450536745 0.0608284423761614 1.00691212823598 0.534883720930233 16.1 16 1 embryonic lethality during organogenesis, incomplete penetrance 3.75378258287657e-09 1.76179890092556e-07 1.00672178567866 0.534782608695652 16.1 16 1 seminiferous tubule degeneration 0.000777735589776142 0.00887115393403425 1.00571270938162 0.534246575342466 16.1 16 1 abnormal craniofacial morphology 7.45534390711006e-05 0.00127458199099218 1.00521198112204 0.533980582524272 16.1 16 1 abnormal hair cycle 0.027615949044347 0.142520068978865 1.00399354235704 0.533333333333333 16.1 16 1 abnormal response to new environment 0.027615949044347 0.142520068978865 1.00399354235704 0.533333333333333 16.1 16 1 liver hemorrhage 0.027615949044347 0.142520068978865 1.00399354235704 0.533333333333333 16.1 16 1 abnormal optic cup morphology 0.027615949044347 0.142520068978865 1.00399354235704 0.533333333333333 16.1 16 1 abnormal cellular respiration 0.027615949044347 0.142520068978865 1.00399354235704 0.533333333333333 16.1 16 1 decreased chondrocyte number 0.108255252654643 0.370700348352211 1.00399354235704 0.533333333333333 16.1 16 1 decreased hepatocyte number 0.108255252654643 0.370700348352211 1.00399354235704 0.533333333333333 16.1 16 1 placental labyrinth hypoplasia 0.108255252654643 0.370700348352211 1.00399354235704 0.533333333333333 16.1 16 1 arthritis 0.108255252654643 0.370700348352211 1.00399354235704 0.533333333333333 16.1 16 1 immune system phenotype 0.108255252654643 0.370700348352211 1.00399354235704 0.533333333333333 16.1 16 1 absent chorion 0.108255252654643 0.370700348352211 1.00399354235704 0.533333333333333 16.1 16 1 infertility 6.08260378913032e-05 0.00107690227227485 1.00282065270475 0.532710280373832 16.1 16 1 retinal degeneration 0.000158696576418269 0.00242182658797818 1.00007169258221 0.53125 16.1 16 1 decreased caudal vertebrae number 0.00186776860184587 0.0184002946419469 1.00007169258221 0.53125 16.1 16 1 scoliosis 0.0245778170468173 0.130038385668372 1.00007169258221 0.53125 16.1 16 1 reduced female fertility 7.42921823422708e-09 3.24813440085258e-07 0.998043149595225 0.530172413793103 16.1 16 1 decreased grip strength 2.09232415191892e-08 8.5322234883579e-07 0.997116874258704 0.529680365296804 16.1 16 1 abnormal lung development 0.000416140586311633 0.00539140473151139 0.996611236898532 0.529411764705882 16.1 16 1 abnormal lung morphology 3.29825904247726e-05 0.00064857070104049 0.996611236898532 0.529411764705882 16.1 16 1 short maxilla 0.0218866870391137 0.122206810347464 0.996611236898532 0.529411764705882 16.1 16 1 abnormal oocyte morphology 0.0218866870391137 0.122206810347464 0.996611236898532 0.529411764705882 16.1 16 1 lung hemorrhage 0.0218866870391137 0.122206810347464 0.996611236898532 0.529411764705882 16.1 16 1 abnormal dorsal-ventral axis patterning 0.0945708313770195 0.34825306151049 0.996611236898532 0.529411764705882 16.1 16 1 decreased vasoconstriction 0.0945708313770195 0.34825306151049 0.996611236898532 0.529411764705882 16.1 16 1 abnormal melanosome morphology 0.0945708313770195 0.34825306151049 0.996611236898532 0.529411764705882 16.1 16 1 pancytopenia 0.0945708313770195 0.34825306151049 0.996611236898532 0.529411764705882 16.1 16 1 coloboma 0.0945708313770195 0.34825306151049 0.996611236898532 0.529411764705882 16.1 16 1 abnormal electroretinogram waveform feature 0.0945708313770195 0.34825306151049 0.996611236898532 0.529411764705882 16.1 16 1 abnormal uterus morphology 0.0195009819016835 0.113870170141872 0.993535276290821 0.527777777777778 16.1 16 1 narrow eye opening 0.0195009819016835 0.113870170141872 0.993535276290821 0.527777777777778 16.1 16 1 short snout 8.55239404741726e-05 0.00144231052155596 0.993535276290821 0.527777777777778 16.1 16 1 abnormal platelet physiology 0.00451768177205948 0.0365253363684068 0.992584524830255 0.527272727272727 16.1 16 1 neonatal lethality, incomplete penetrance 1.82856619880491e-09 9.1890069081358e-08 0.991926312280633 0.526923076923077 16.1 16 1 decreased brain weight 0.00405109332478792 0.0341018431316749 0.990783101010237 0.526315789473684 16.1 16 1 abnormal reproductive system physiology 0.0173843851476647 0.103206821133212 0.990783101010237 0.526315789473684 16.1 16 1 hyporesponsive to tactile stimuli 0.0173843851476647 0.103206821133212 0.990783101010237 0.526315789473684 16.1 16 1 shiny skin 0.0828581568607812 0.315393519802897 0.990783101010237 0.526315789473684 16.1 16 1 thin dermal layer 0.0828581568607812 0.315393519802897 0.990783101010237 0.526315789473684 16.1 16 1 short vibrissae 0.0828581568607812 0.315393519802897 0.990783101010237 0.526315789473684 16.1 16 1 abnormal stationary movement 0.0828581568607812 0.315393519802897 0.990783101010237 0.526315789473684 16.1 16 1 delayed sexual maturation 0.0828581568607812 0.315393519802897 0.990783101010237 0.526315789473684 16.1 16 1 abnormal nasal septum morphology 0.0828581568607812 0.315393519802897 0.990783101010237 0.526315789473684 16.1 16 1 increased liver cholesterol level 0.0828581568607812 0.315393519802897 0.990783101010237 0.526315789473684 16.1 16 1 increased rib number 0.000888446121868153 0.00986611485779924 0.989512866265352 0.525641025641026 16.1 16 1 absent gastric milk in neonates 0.000888446121868153 0.00986611485779924 0.989512866265352 0.525641025641026 16.1 16 1 impaired glucose tolerance 7.11461318266332e-09 3.18715769680161e-07 0.986788007861002 0.524193548387097 16.1 16 1 increased circulating HDL cholesterol level 0.000146649892872133 0.00228709472425975 0.986065086243521 0.523809523809524 16.1 16 1 abnormal muscle morphology 0.0138354695304088 0.0875718332236432 0.986065086243521 0.523809523809524 16.1 16 1 abnormal salivary gland morphology 0.0727742784434023 0.283295802234684 0.986065086243521 0.523809523809524 16.1 16 1 dry skin 0.0727742784434023 0.283295802234684 0.986065086243521 0.523809523809524 16.1 16 1 increased acute inflammation 0.0727742784434023 0.283295802234684 0.986065086243521 0.523809523809524 16.1 16 1 abnormal bile salt homeostasis 0.0727742784434023 0.283295802234684 0.986065086243521 0.523809523809524 16.1 16 1 increased keratinocyte proliferation 0.0727742784434023 0.283295802234684 0.986065086243521 0.523809523809524 16.1 16 1 embryonic lethality at implantation, complete penetrance 0.0727742784434023 0.283295802234684 0.986065086243521 0.523809523809524 16.1 16 1 increased circulating cholesterol level 1.22651212765832e-06 3.67584206933744e-05 0.984027761685167 0.522727272727273 16.1 16 1 abnormal suckling behavior 0.00052333164880314 0.00651902555153569 0.984027761685167 0.522727272727273 16.1 16 1 cochlear hair cell degeneration 0.0123510018792487 0.0791832916871935 0.984027761685167 0.522727272727273 16.1 16 1 decreased bone mineral density 2.86162209113804e-09 1.38219125275842e-07 0.983706078860163 0.522556390977444 16.1 16 1 perinatal lethality, incomplete penetrance 4.57015478138292e-08 1.79027716829764e-06 0.982891908170332 0.52212389380531 16.1 16 1 hydroencephaly 8.70943785246779e-05 0.00145890415205479 0.982167595784061 0.521739130434783 16.1 16 1 decreased spleen weight 0.00211301097160754 0.0203725379529991 0.982167595784061 0.521739130434783 16.1 16 1 abnormal cranial nerve morphology 0.0640512591762153 0.254110856779642 0.98216759578406 0.521739130434783 16.1 16 1 abnormal regulatory T cell physiology 0.0640512591762153 0.254110856779642 0.98216759578406 0.521739130434783 16.1 16 1 abnormal palatal shelf fusion at midline 0.0640512591762153 0.254110856779642 0.98216759578406 0.521739130434783 16.1 16 1 decreased effector memory CD8-positive, alpha-beta T cell number 0.0640512591762153 0.254110856779642 0.98216759578406 0.521739130434783 16.1 16 1 increased circulating free fatty acid level 0.00189674684130599 0.0185025794813673 0.981014816915769 0.52112676056338 16.1 16 1 abnormal skeletal muscle fiber morphology 0.00189674684130599 0.0185025794813673 0.981014816915769 0.52112676056338 16.1 16 1 curly tail 0.00985479668117105 0.0679028926341028 0.980462443708047 0.520833333333333 16.1 16 1 decreased heart rate 0.000277805051418519 0.00380738328046041 0.978893703798114 0.52 16.1 16 1 short stride length 0.00880776544005764 0.061284801488513 0.978893703798114 0.52 16.1 16 1 abnormal thyroid gland morphology 0.0564755945765053 0.228799741871428 0.978893703798114 0.52 16.1 16 1 decreased placenta weight 0.0564755945765053 0.228799741871428 0.978893703798114 0.52 16.1 16 1 weight loss 1.87017279523932e-06 5.19782662364001e-05 0.978893703798114 0.52 16.1 16 1 postnatal growth retardation 7.85510363202372e-19 2.17106336496211e-16 0.978155473252263 0.519607843137255 16.1 16 1 cleft palate 3.78756949324433e-05 0.000733196818244769 0.977169287408569 0.519083969465649 16.1 16 1 abnormal nervous system morphology 0.00123313517076033 0.013221654039941 0.976987386945537 0.518987341772152 16.1 16 1 abnormal axon morphology 0.000182325691616409 0.00270759019551855 0.976104832847122 0.518518518518518 16.1 16 1 abnormal maxilla morphology 0.00704286866999952 0.0507801038163009 0.976104832847122 0.518518518518518 16.1 16 1 abnormal bone trabecula morphology 0.0498744475371857 0.219288167925828 0.976104832847122 0.518518518518518 16.1 16 1 decreased bone ossification 0.0498744475371857 0.219288167925828 0.976104832847122 0.518518518518518 16.1 16 1 abnormal microglial cell morphology 0.0441060943949429 0.199633515606211 0.973700633751439 0.517241379310345 16.1 16 1 abnormal circulating glucose level 0.0441060943949429 0.199633515606211 0.973700633751439 0.517241379310345 16.1 16 1 respiratory failure 1.34008117175122e-05 0.00029113117159224 0.972410964037861 0.516556291390728 16.1 16 1 increased sensitivity to induced morbidity/mortality 1.69410820479485e-06 4.73493725778336e-05 0.971936683327976 0.516304347826087 16.1 16 1 prenatal lethality 0.00451963082191793 0.0365253363684068 0.971606653893909 0.516129032258065 16.1 16 1 absent mature ovarian follicles 0.0390530864994071 0.191597140076505 0.971606653893909 0.516129032258065 16.1 16 1 abnormal eyelid morphology 0.0390530864994071 0.191597140076505 0.971606653893909 0.516129032258065 16.1 16 1 abnormal retinal photoreceptor layer morphology 0.0390530864994071 0.191597140076505 0.971606653893909 0.516129032258065 16.1 16 1 abnormal motor coordination/ balance 0.000423627211579035 0.00544959989314522 0.969766489776686 0.515151515151515 16.1 16 1 thick epidermis 0.00291237350662214 0.0257812423406497 0.968136630130003 0.514285714285714 16.1 16 1 increased red blood cell distribution width 0.0307157992363299 0.156568751230268 0.968136630130003 0.514285714285714 16.1 16 1 impaired adaptive thermogenesis 0.0307157992363299 0.156568751230268 0.968136630130003 0.514285714285714 16.1 16 1 increased circulating phosphate level 0.0272786801134062 0.141661204137991 0.966682971526204 0.513513513513513 16.1 16 1 abnormal respiratory electron transport chain 0.0272786801134062 0.141661204137991 0.966682971526204 0.513513513513513 16.1 16 1 abnormal cornea morphology 0.00188310428102959 0.0185025794813673 0.965378406112538 0.512820512820513 16.1 16 1 increased vascular permeability 0.0242460959336804 0.129425243851995 0.965378406112538 0.512820512820513 16.1 16 1 abnormal circulating hormone level 0.0242460959336804 0.129425243851995 0.965378406112538 0.512820512820513 16.1 16 1 scaly skin 0.0215668515947234 0.120827800319537 0.964201115373376 0.51219512195122 16.1 16 1 decreased oxygen consumption 0.0191969166994996 0.112490766289765 0.963133340051811 0.511627906976744 16.1 16 1 abnormal cardiovascular system physiology 7.02428902632538e-05 0.00122188244426464 0.962475012409944 0.511278195488722 16.1 16 1 decreased bone trabecula number 0.0152380398127754 0.0923376955768059 0.961270412895038 0.51063829787234 16.1 16 1 increased circulating LDL cholesterol level 0.0135875981087712 0.0862223221825724 0.960453006081352 0.510204081632653 16.1 16 1 increased fluid intake 0.0135875981087712 0.0862223221825724 0.960453006081352 0.510204081632653 16.1 16 1 ataxia 1.3551231089735e-06 4.01293896853759e-05 0.959882439939125 0.50990099009901 16.1 16 1 abnormal enzyme/coenzyme activity 1.99606282053048e-05 0.000417892972540379 0.959229499067236 0.509554140127389 16.1 16 1 abnormal mesoderm development 0.0108197289539602 0.0720591051485303 0.959003265694814 0.509433962264151 16.1 16 1 increased circulating bilirubin level 0.0108197289539602 0.0720591051485303 0.959003265694814 0.509433962264151 16.1 16 1 hypoactivity 5.80084389421236e-11 3.69989722739827e-09 0.958720624001417 0.509283819628647 16.1 16 1 neonatal lethality, complete penetrance 7.03327471655642e-13 6.47972994719781e-11 0.957756997643229 0.508771929824561 16.1 16 1 absent vitelline blood vessels 0.00863097894316187 0.0603077531491999 0.957756997643229 0.508771929824561 16.1 16 1 decreased susceptibility to induced arthritis 0.00863097894316187 0.0603077531491999 0.957756997643229 0.508771929824561 16.1 16 1 abnormal kidney morphology 7.79912381058272e-06 0.000178804797039857 0.957379556461891 0.508571428571429 16.1 16 1 abnormal colon morphology 0.00771331249335085 0.0554533665526307 0.957197233179381 0.508474576271186 16.1 16 1 skin lesions 0.00616694919246003 0.0447891565437791 0.956184326054324 0.507936507936508 16.1 16 1 postnatal lethality, complete penetrance 5.14013350245339e-11 3.3210602824293e-09 0.955874680871016 0.507772020725389 16.1 16 1 decreased monocyte cell number 0.0055169791394078 0.0411498818868872 0.955724622051413 0.507692307692308 16.1 16 1 abnormal epidermal layer morphology 0.00441933606304433 0.0365253363684068 0.954885162567837 0.507246376811594 16.1 16 1 abnormal neurocranium morphology 0.00317486942862231 0.0280052755450283 0.953793865239188 0.506666666666667 16.1 16 1 increased or absent threshold for auditory brainstem response 2.11530497474066e-08 8.55580670677626e-07 0.951014644360691 0.505190311418685 16.1 16 1 female infertility 9.7182903177215e-08 3.55503634784298e-06 0.948320968109798 0.503759398496241 16.1 16 1 reduced fertility 0.000102271333226595 0.00164660156246703 0.948015485139291 0.503597122302158 16.1 16 1 microphthalmia 4.88853978641374e-05 0.000894135494022365 0.947395867175148 0.503267973856209 16.1 16 1 no abnormal phenotype detected 2.46044092061519e-42 2.44813871601211e-39 0.945041471966479 0.502017291066282 16.1 16 1 reduced long term potentiation 0.000602051809094942 0.00728053262144219 0.941243945959725 0.5 16.1 16 1 abnormal axon extension 0.0183674307774849 0.108139607240222 0.941243945959725 0.5 16.1 16 1 decreased respiratory quotient 0.0183674307774849 0.108139607240222 0.941243945959725 0.5 16.1 16 1 abnormal gametogenesis 0.0260428315197505 0.136382196642904 0.941243945959725 0.5 16.1 16 1 abnormal amino acid level 0.0260428315197505 0.136382196642904 0.941243945959725 0.5 16.1 16 1 lethality, incomplete penetrance 0.0260428315197505 0.136382196642904 0.941243945959725 0.5 16.1 16 1 heart right ventricle hypertrophy 0.0419306165709763 0.191908755695131 0.941243945959725 0.5 16.1 16 1 impaired wound healing 0.0419306165709763 0.191908755695131 0.941243945959725 0.5 16.1 16 1 abnormal retinal blood vessel morphology 0.0419306165709763 0.191908755695131 0.941243945959725 0.5 16.1 16 1 shortened head 0.0687001839236153 0.271472132660831 0.941243945959725 0.5 16.1 16 1 abnormal facial nerve morphology 0.101247973725145 0.365990183734001 0.941243945959725 0.5 16.1 16 1 intracerebral hemorrhage 0.101247973725145 0.365990183734001 0.941243945959725 0.5 16.1 16 1 testis hypoplasia 0.101247973725145 0.365990183734001 0.941243945959725 0.5 16.1 16 1 abnormal chorion morphology 0.101247973725145 0.365990183734001 0.941243945959725 0.5 16.1 16 1 parakeratosis 0.101247973725145 0.365990183734001 0.941243945959725 0.5 16.1 16 1 pulmonary vascular congestion 0.101247973725145 0.365990183734001 0.941243945959725 0.5 16.1 16 1 rough coat 0.101247973725145 0.365990183734001 0.941243945959725 0.5 16.1 16 1 lowered ear position 0.13280787568162 0.392351057907397 0.941243945959725 0.5 16.1 16 1 abnormal heart shape 0.13280787568162 0.392351057907397 0.941243945959725 0.5 16.1 16 1 abnormal retinal rod cell morphology 0.13280787568162 0.392351057907397 0.941243945959725 0.5 16.1 16 1 thick dermal layer 0.13280787568162 0.392351057907397 0.941243945959725 0.5 16.1 16 1 abnormal metacarpal bone morphology 0.13280787568162 0.392351057907397 0.941243945959725 0.5 16.1 16 1 absent allantois 0.13280787568162 0.392351057907397 0.941243945959725 0.5 16.1 16 1 increased circulating renin level 0.13280787568162 0.392351057907397 0.941243945959725 0.5 16.1 16 1 abnormal body wall morphology 0.13280787568162 0.392351057907397 0.941243945959725 0.5 16.1 16 1 decreased fluid intake 0.13280787568162 0.392351057907397 0.941243945959725 0.5 16.1 16 1 megacephaly 0.17694830697548 0.494005514704274 0.941243945959725 0.5 16.1 16 1 abnormal adrenal gland secretion 0.17694830697548 0.494005514704274 0.941243945959725 0.5 16.1 16 1 abnormal antigen presentation 0.17694830697548 0.494005514704274 0.941243945959725 0.5 16.1 16 1 decreased vascular permeability 0.17694830697548 0.494005514704274 0.941243945959725 0.5 16.1 16 1 intestinal obstruction 0.17694830697548 0.494005514704274 0.941243945959725 0.5 16.1 16 1 abnormal ventral body wall morphology 0.17694830697548 0.494005514704274 0.941243945959725 0.5 16.1 16 1 abnormal decidualization 0.17694830697548 0.494005514704274 0.941243945959725 0.5 16.1 16 1 spina bifida occulta 0.17694830697548 0.494005514704274 0.941243945959725 0.5 16.1 16 1 increased pulmonary respiratory rate 0.17694830697548 0.494005514704274 0.941243945959725 0.5 16.1 16 1 sternebra fusion 0.17694830697548 0.494005514704274 0.941243945959725 0.5 16.1 16 1 increased stomach tumor incidence 0.17694830697548 0.494005514704274 0.941243945959725 0.5 16.1 16 1 pulmonary alveolar hemorrhage 0.17694830697548 0.494005514704274 0.941243945959725 0.5 16.1 16 1 decreased compact bone area 0.17694830697548 0.494005514704274 0.941243945959725 0.5 16.1 16 1 abnormal cranium morphology 0.000186377165718154 0.00271913900131325 0.941243945959725 0.5 16.1 16 1 increased total body fat amount 0.000186377165718154 0.00271913900131325 0.941243945959725 0.5 16.1 16 1 insulin resistance 0.000207243994042896 0.00297790011073435 0.941243945959725 0.5 16.1 16 1 domed cranium 0.00592629861946655 0.0431595398752837 0.941243945959725 0.5 16.1 16 1 neurodegeneration 0.014596589237921 0.0896518906897002 0.941243945959725 0.5 16.1 16 1 abnormal osteoclast morphology 0.0206212829443798 0.119989336430748 0.941243945959725 0.5 16.1 16 1 perinatal lethality 0.0329870467502811 0.164935233751406 0.941243945959725 0.5 16.1 16 1 impaired synaptic plasticity 0.0473477670564433 0.211103565539093 0.941243945959725 0.5 16.1 16 1 abnormal vertebral body morphology 0.0535283559519968 0.220790661005185 0.941243945959725 0.5 16.1 16 1 abnormal depression-related behavior 0.0535283559519968 0.220790661005185 0.941243945959725 0.5 16.1 16 1 abnormal brain vasculature morphology 0.0605962397455389 0.24469666618024 0.941243945959725 0.5 16.1 16 1 abnormal nursing 0.0887782984531423 0.336127880368632 0.941243945959725 0.5 16.1 16 1 abnormal vasodilation 0.0887782984531423 0.336127880368632 0.941243945959725 0.5 16.1 16 1 abnormal sensory capabilities/reflexes/nociception 0.0887782984531423 0.336127880368632 0.941243945959725 0.5 16.1 16 1 increased body temperature 0.0887782984531423 0.336127880368632 0.941243945959725 0.5 16.1 16 1 increased urine glucose level 0.115775912865288 0.370700348352211 0.941243945959725 0.5 16.1 16 1 abnormal dopamine level 0.115775912865288 0.370700348352211 0.941243945959725 0.5 16.1 16 1 abnormal postnatal subventricular zone morphology 0.115775912865288 0.370700348352211 0.941243945959725 0.5 16.1 16 1 decreased circulating VLDL cholesterol level 0.115775912865288 0.370700348352211 0.941243945959725 0.5 16.1 16 1 abnormal circulating cytokine level 0.115775912865288 0.370700348352211 0.941243945959725 0.5 16.1 16 1 abnormal hair follicle orientation 0.15293187086008 0.441064381176173 0.941243945959725 0.5 16.1 16 1 reduced male mating frequency 0.15293187086008 0.441064381176173 0.941243945959725 0.5 16.1 16 1 disorganized yolk sac vascular plexus 0.15293187086008 0.441064381176173 0.941243945959725 0.5 16.1 16 1 intraventricular hemorrhage 0.15293187086008 0.441064381176173 0.941243945959725 0.5 16.1 16 1 abnormal meiosis 0.15293187086008 0.441064381176173 0.941243945959725 0.5 16.1 16 1 abnormal epicardium morphology 0.15293187086008 0.441064381176173 0.941243945959725 0.5 16.1 16 1 impaired muscle relaxation 0.15293187086008 0.441064381176173 0.941243945959725 0.5 16.1 16 1 increased thymus weight 0.15293187086008 0.441064381176173 0.941243945959725 0.5 16.1 16 1 sepsis 0.15293187086008 0.441064381176173 0.941243945959725 0.5 16.1 16 1 loose skin 0.15293187086008 0.441064381176173 0.941243945959725 0.5 16.1 16 1 decreased circulating triiodothyronine level 0.15293187086008 0.441064381176173 0.941243945959725 0.5 16.1 16 1 decreased creatinine clearance 0.15293187086008 0.441064381176173 0.941243945959725 0.5 16.1 16 1 dilated respiratory conducting tubes 0.15293187086008 0.441064381176173 0.941243945959725 0.5 16.1 16 1 abnormal pulmonary alveolus wall morphology 0.15293187086008 0.441064381176173 0.941243945959725 0.5 16.1 16 1 abnormal rectum morphology 0.20599224155581 0.547149707282516 0.941243945959725 0.5 16.1 16 1 mesocardia 0.20599224155581 0.547149707282516 0.941243945959725 0.5 16.1 16 1 abnormal superior cervical ganglion morphology 0.20599224155581 0.547149707282516 0.941243945959725 0.5 16.1 16 1 abnormal enteric nervous system morphology 0.20599224155581 0.547149707282516 0.941243945959725 0.5 16.1 16 1 absent optic nerve 0.20599224155581 0.547149707282516 0.941243945959725 0.5 16.1 16 1 ear inflammation 0.20599224155581 0.547149707282516 0.941243945959725 0.5 16.1 16 1 abnormal gastrocnemius morphology 0.20599224155581 0.547149707282516 0.941243945959725 0.5 16.1 16 1 abnormal alisphenoid bone morphology 0.20599224155581 0.547149707282516 0.941243945959725 0.5 16.1 16 1 delayed somite formation 0.20599224155581 0.547149707282516 0.941243945959725 0.5 16.1 16 1 decreased left ventricle systolic pressure 0.20599224155581 0.547149707282516 0.941243945959725 0.5 16.1 16 1 abnormal rostral-caudal body axis extension 0.20599224155581 0.547149707282516 0.941243945959725 0.5 16.1 16 1 bowed ulna 0.20599224155581 0.547149707282516 0.941243945959725 0.5 16.1 16 1 abnormal cochlear outer hair cell physiology 0.20599224155581 0.547149707282516 0.941243945959725 0.5 16.1 16 1 abnormal somatic nervous system physiology 0.20599224155581 0.547149707282516 0.941243945959725 0.5 16.1 16 1 decreased prostaglandin level 0.20599224155581 0.547149707282516 0.941243945959725 0.5 16.1 16 1 increased skeletal muscle glycogen level 0.20599224155581 0.547149707282516 0.941243945959725 0.5 16.1 16 1 retarded hair growth 0.241764031739256 0.601990018970369 0.941243945959725 0.5 16.1 16 1 abnormal grooming behavior 0.241764031739256 0.601990018970369 0.941243945959725 0.5 16.1 16 1 absent trophoblast giant cells 0.241764031739256 0.601990018970369 0.941243945959725 0.5 16.1 16 1 abnormal mammary gland physiology 0.241764031739256 0.601990018970369 0.941243945959725 0.5 16.1 16 1 impaired social transmission of food preference 0.241764031739256 0.601990018970369 0.941243945959725 0.5 16.1 16 1 primary sex reversal 0.241764031739256 0.601990018970369 0.941243945959725 0.5 16.1 16 1 impaired basement membrane formation 0.241764031739256 0.601990018970369 0.941243945959725 0.5 16.1 16 1 abnormal glial cell physiology 0.241764031739256 0.601990018970369 0.941243945959725 0.5 16.1 16 1 increased heart rate variability 0.241764031739256 0.601990018970369 0.941243945959725 0.5 16.1 16 1 abnormal deltoid tuberosity morphology 0.241764031739256 0.601990018970369 0.941243945959725 0.5 16.1 16 1 abnormal corneal endothelium morphology 0.241764031739256 0.601990018970369 0.941243945959725 0.5 16.1 16 1 ascites 0.241764031739256 0.601990018970369 0.941243945959725 0.5 16.1 16 1 increased susceptibility to atherosclerosis 0.241764031739256 0.601990018970369 0.941243945959725 0.5 16.1 16 1 abnormal developmental vascular remodeling 0.241764031739256 0.601990018970369 0.941243945959725 0.5 16.1 16 1 increased platelet aggregation 0.241764031739256 0.601990018970369 0.941243945959725 0.5 16.1 16 1 abnormal spinal cord dorsal column morphology 0.241764031739256 0.601990018970369 0.941243945959725 0.5 16.1 16 1 ventricular premature beat 0.241764031739256 0.601990018970369 0.941243945959725 0.5 16.1 16 1 abnormal sperm principal piece morphology 0.241764031739256 0.601990018970369 0.941243945959725 0.5 16.1 16 1 protruding tongue 0.241764031739256 0.601990018970369 0.941243945959725 0.5 16.1 16 1 abnormal hippocampus neuron morphology 0.241764031739256 0.601990018970369 0.941243945959725 0.5 16.1 16 1 umbilical hernia 0.241764031739256 0.601990018970369 0.941243945959725 0.5 16.1 16 1 increased T-helper 17 cell number 0.241764031739256 0.601990018970369 0.941243945959725 0.5 16.1 16 1 increased kidney iron level 0.241764031739256 0.601990018970369 0.941243945959725 0.5 16.1 16 1 aorta stenosis 0.241764031739256 0.601990018970369 0.941243945959725 0.5 16.1 16 1 abnormal circadian temperature homeostasis 0.241764031739256 0.601990018970369 0.941243945959725 0.5 16.1 16 1 abnormal retina morphology 3.45107893525591e-06 8.62769733813977e-05 0.941243945959725 0.5 16.1 16 1 kyphosis 7.99610812401809e-05 0.0013530829223466 0.941243945959725 0.5 16.1 16 1 abnormal enzyme/coenzyme level 0.0116232466101463 0.075195906222988 0.941243945959725 0.5 16.1 16 1 abnormal brain wave pattern 0.0163694067809868 0.0989523678437537 0.941243945959725 0.5 16.1 16 1 abnormal kidney cortex morphology 0.0780205283661124 0.303007126168157 0.941243945959725 0.5 16.1 16 1 reduced male fertility 1.97271808761109e-06 5.45237360325844e-05 0.937097496858581 0.497797356828194 16.1 16 1 abnormal brain morphology 6.21486872977449e-05 0.00109641744434851 0.935397710270534 0.496894409937888 16.1 16 1 increased body weight 3.17944886055466e-06 8.15348354704095e-05 0.932839982156513 0.495535714285714 16.1 16 1 decreased litter size 2.26902918763228e-07 7.89400014578365e-06 0.931195078209265 0.494661921708185 16.1 16 1 small ovary 0.00260661160200005 0.024014616148056 0.930900605894233 0.494505494505495 16.1 16 1 abnormal visceral yolk sac morphology 0.00503209358549291 0.0390556405426322 0.929329465631121 0.493670886075949 16.1 16 1 corneal opacity 0.00784087692497136 0.0561271405780324 0.927986988974376 0.492957746478873 16.1 16 1 abnormal sternum morphology 0.00876686204069018 0.061085628364753 0.927602729351613 0.492753623188406 16.1 16 1 rib fusion 0.00980547849338808 0.0677531326452857 0.927195528855848 0.492537313432836 16.1 16 1 abnormal maternal nurturing 0.0137499949491439 0.0871416877350201 0.925813717337434 0.491803278688525 16.1 16 1 increased circulating calcium level 0.0193553471733338 0.113285708455689 0.924130419669548 0.490909090909091 16.1 16 1 abnormal cervical vertebrae morphology 0.024372586590125 0.129821861119777 0.922788182313456 0.490196078431373 16.1 16 1 cochlear inner hair cell degeneration 0.024372586590125 0.129821861119777 0.922788182313456 0.490196078431373 16.1 16 1 decreased circulating creatinine level 0.0273736203865639 0.142006007740517 0.922034885838098 0.489795918367347 16.1 16 1 decreased osteoclast cell number 0.0345984855410161 0.17281874052867 0.920327413827286 0.488888888888889 16.1 16 1 arrest of spermatogenesis 0.00527644485317141 0.0399548145274395 0.918833375817826 0.488095238095238 16.1 16 1 decreased anxiety-related response 0.000878176330218597 0.00979580099290923 0.918286776546073 0.48780487804878 16.1 16 1 abnormal heart looping 0.0494535102673419 0.218112777996477 0.917109485806911 0.487179487179487 16.1 16 1 abnormal long bone metaphysis morphology 0.055811398478148 0.228597545420298 0.915804920393246 0.486486486486487 16.1 16 1 decreased circulating chloride level 0.055811398478148 0.228597545420298 0.915804920393246 0.486486486486487 16.1 16 1 abnormal hair follicle development 0.055811398478148 0.228597545420298 0.915804920393246 0.486486486486487 16.1 16 1 cochlear outer hair cell degeneration 0.0102413568898607 0.0698912901605723 0.915098280794177 0.486111111111111 16.1 16 1 abnormal dermal layer morphology 0.0630557366643282 0.25257833325687 0.914351261789447 0.485714285714286 16.1 16 1 abnormal artery morphology 0.0630557366643282 0.25257833325687 0.914351261789447 0.485714285714286 16.1 16 1 abnormal intestinal goblet cell morphology 0.0630557366643282 0.25257833325687 0.914351261789447 0.485714285714286 16.1 16 1 holoprosencephaly 0.0630557366643282 0.25257833325687 0.914351261789447 0.485714285714286 16.1 16 1 decreased circulating thyroxine level 0.0630557366643282 0.25257833325687 0.914351261789447 0.485714285714286 16.1 16 1 decreased bone volume 0.0630557366643282 0.25257833325687 0.914351261789447 0.485714285714286 16.1 16 1 decreased bone mineralization 0.0630557366643282 0.25257833325687 0.914351261789447 0.485714285714286 16.1 16 1 impaired coordination 6.7745974589987e-08 2.55330472413019e-06 0.914040363706554 0.485549132947977 16.1 16 1 belly spot 0.0713270655089082 0.28051553431369 0.912721402142763 0.484848484848485 16.1 16 1 decreased systemic arterial blood pressure 0.0713270655089082 0.28051553431369 0.912721402142763 0.484848484848485 16.1 16 1 cardiovascular system phenotype 0.0713270655089082 0.28051553431369 0.912721402142763 0.484848484848485 16.1 16 1 decreased sensitivity to xenobiotic induced morbidity/mortality 0.0713270655089082 0.28051553431369 0.912721402142763 0.484848484848485 16.1 16 1 abnormal mitochondrial ATP synthesis coupled electron transport 0.0807929459137874 0.311188399555401 0.91088123802554 0.483870967741935 16.1 16 1 abnormal spinal nerve morphology 0.0916546674837094 0.34053918650594 0.90878725816801 0.482758620689655 16.1 16 1 decreased bone strength 0.0916546674837094 0.34053918650594 0.90878725816801 0.482758620689655 16.1 16 1 increased retinal apoptosis 0.0916546674837094 0.34053918650594 0.90878725816801 0.482758620689655 16.1 16 1 abnormal eye development 0.0252516321761269 0.132657729753148 0.907628090746877 0.482142857142857 16.1 16 1 postnatal lethality 0.000225006719431458 0.00317112869453683 0.907223080443108 0.481927710843373 16.1 16 1 abnormal chondrocyte morphology 0.0283221390354542 0.145711108274441 0.906383059072328 0.481481481481481 16.1 16 1 diluted coat color 0.0283221390354542 0.145711108274441 0.906383059072328 0.481481481481481 16.1 16 1 abnormal skin appearance 0.104156174850116 0.370214827977186 0.906383059072328 0.481481481481481 16.1 16 1 cachexia 0.00329628793811812 0.0288401838545375 0.905042255730504 0.480769230769231 16.1 16 1 decreased kidney weight 0.0317829382652532 0.16052803844633 0.905042255730504 0.480769230769231 16.1 16 1 testicular atrophy 0.0356870261795601 0.17772067591923 0.903594188121336 0.48 16.1 16 1 decreased oocyte number 0.0356870261795601 0.17772067591923 0.903594188121336 0.48 16.1 16 1 abnormal keratinocyte physiology 0.118596178954653 0.370700348352211 0.903594188121336 0.48 16.1 16 1 abnormal gait 1.08003044494883e-06 3.25645543249724e-05 0.901644686097341 0.478964401294498 16.1 16 1 decreased startle reflex 0.00221320435805877 0.0211744070795046 0.901019845705036 0.478632478632479 16.1 16 1 abnormal sleep pattern 0.0450780821273222 0.202769854053733 0.900320296135389 0.478260869565217 16.1 16 1 abnormal myelin sheath morphology 0.0450780821273222 0.202769854053733 0.900320296135389 0.478260869565217 16.1 16 1 abnormal blood vessel physiology 0.135344962061664 0.398426737430046 0.900320296135389 0.478260869565217 16.1 16 1 conjunctivitis 0.135344962061664 0.398426737430046 0.900320296135389 0.478260869565217 16.1 16 1 abnormal nasal cavity morphology 0.135344962061664 0.398426737430046 0.900320296135389 0.478260869565217 16.1 16 1 abnormal lens development 0.135344962061664 0.398426737430046 0.900320296135389 0.478260869565217 16.1 16 1 teratozoospermia 0.00782854213908278 0.0561195924235401 0.898460130234283 0.477272727272727 16.1 16 1 abnormal astrocyte morphology 0.0507164404949359 0.220182631272341 0.898460130234283 0.477272727272727 16.1 16 1 abnormal anxiety-related response 0.154868307794276 0.445101000159747 0.896422805675928 0.476190476190476 16.1 16 1 abnormal embryonic/fetal subventricular zone morphology 0.154868307794276 0.445101000159747 0.896422805675928 0.476190476190476 16.1 16 1 abnormal female reproductive system morphology 0.0643517391637297 0.255099523776538 0.894181748661738 0.475 16.1 16 1 improved glucose tolerance 0.00014996508088726 0.00232422516328386 0.893221295655657 0.474489795918367 16.1 16 1 increased circulating alanine transaminase level 0.0135194640094469 0.0861914365070381 0.892975025654098 0.474358974358974 16.1 16 1 abnormal heart ventricle morphology 0.0135194640094469 0.0861914365070381 0.892975025654098 0.474358974358974 16.1 16 1 respiratory distress 0.000370780384221993 0.00482888065838852 0.892277497904016 0.473988439306358 16.1 16 1 abnormal blood homeostasis 0.00346774643035634 0.0298478174585169 0.891704790909213 0.473684210526316 16.1 16 1 abnormal craniofacial bone morphology 0.0324421239977291 0.162800125965621 0.891704790909213 0.473684210526316 16.1 16 1 irregular coat pigmentation 0.177762622620374 0.494613561261948 0.891704790909213 0.473684210526316 16.1 16 1 abnormal long term depression 0.177762622620374 0.494613561261948 0.891704790909213 0.473684210526316 16.1 16 1 abnormal neural crest cell migration 0.177762622620374 0.494613561261948 0.891704790909213 0.473684210526316 16.1 16 1 increased circulating VLDL cholesterol level 0.177762622620374 0.494613561261948 0.891704790909213 0.473684210526316 16.1 16 1 decreased circulating magnesium level 0.177762622620374 0.494613561261948 0.891704790909213 0.473684210526316 16.1 16 1 abnormal contextual conditioning behavior 0.0363613317394241 0.179284068784574 0.889903367089194 0.472727272727273 16.1 16 1 abnormal learning/memory/conditioning 0.0363613317394241 0.179284068784574 0.889903367089194 0.472727272727273 16.1 16 1 abnormal rostral-caudal axis patterning 0.0363613317394241 0.179284068784574 0.889903367089194 0.472727272727273 16.1 16 1 abnormal pharyngeal arch morphology 0.0819571599057482 0.313885196713701 0.888952615628629 0.472222222222222 16.1 16 1 increased startle reflex 0.00992494336645116 0.0680118364298823 0.888365072591201 0.471910112359551 16.1 16 1 abnormal pancreatic islet morphology 0.040773471551381 0.191597140076505 0.887965986754457 0.471698113207547 16.1 16 1 abnormal gluconeogenesis 0.0457443058146132 0.20502515443937 0.885876655020917 0.470588235294118 16.1 16 1 abnormal response to novel object 0.0457443058146132 0.20502515443937 0.885876655020917 0.470588235294118 16.1 16 1 increased kidney weight 0.0457443058146132 0.20502515443937 0.885876655020917 0.470588235294118 16.1 16 1 abnormal thrombosis 0.0457443058146132 0.20502515443937 0.885876655020917 0.470588235294118 16.1 16 1 thin skin 0.0926419974666547 0.342927036753428 0.885876655020917 0.470588235294118 16.1 16 1 abnormal endoderm development 0.0926419974666547 0.342927036753428 0.885876655020917 0.470588235294118 16.1 16 1 abnormal nervous system development 0.0926419974666547 0.342927036753428 0.885876655020917 0.470588235294118 16.1 16 1 increased susceptibility to weight gain 0.0926419974666547 0.342927036753428 0.885876655020917 0.470588235294118 16.1 16 1 distended urinary bladder 0.204808350400578 0.547149707282516 0.885876655020917 0.470588235294118 16.1 16 1 abnormal vagus nerve morphology 0.204808350400578 0.547149707282516 0.885876655020917 0.470588235294118 16.1 16 1 hyperlipidemia 0.204808350400578 0.547149707282516 0.885876655020917 0.470588235294118 16.1 16 1 abnormal glutamate-mediated receptor currents 0.204808350400578 0.547149707282516 0.885876655020917 0.470588235294118 16.1 16 1 aminoaciduria 0.204808350400578 0.547149707282516 0.885876655020917 0.470588235294118 16.1 16 1 abnormal testis development 0.204808350400578 0.547149707282516 0.885876655020917 0.470588235294118 16.1 16 1 abnormal ductus venosus valve morphology 0.204808350400578 0.547149707282516 0.885876655020917 0.470588235294118 16.1 16 1 impaired swimming 0.026243470805304 0.136713368854856 0.884198858325802 0.46969696969697 16.1 16 1 organ of Corti degeneration 0.0513491542906795 0.220182631272341 0.883616765594844 0.469387755102041 16.1 16 1 absent kidney 0.0513491542906795 0.220182631272341 0.883616765594844 0.469387755102041 16.1 16 1 hyperactivity 7.33588445314688e-07 2.32458758945259e-05 0.882891895401575 0.46900269541779 16.1 16 1 cyanosis 0.000318655020896579 0.0042735044582077 0.882416199337242 0.46875 16.1 16 1 abnormal lens morphology 0.00290437382807153 0.0257562563184597 0.882416199337242 0.46875 16.1 16 1 decreased eosinophil cell number 0.0293397701960647 0.149861762551768 0.882416199337242 0.46875 16.1 16 1 abnormal crypts of Lieberkuhn morphology 0.104849937056544 0.370700348352211 0.882416199337242 0.46875 16.1 16 1 abnormal diaphragm morphology 0.104849937056544 0.370700348352211 0.882416199337242 0.46875 16.1 16 1 abnormal heart atrium morphology 0.104849937056544 0.370700348352211 0.882416199337242 0.46875 16.1 16 1 decreased susceptibility to parasitic infection 0.104849937056544 0.370700348352211 0.882416199337242 0.46875 16.1 16 1 pancreatic islet hyperplasia 0.104849937056544 0.370700348352211 0.882416199337242 0.46875 16.1 16 1 abnormal auditory brainstem response waveform shape 0.104849937056544 0.370700348352211 0.882416199337242 0.46875 16.1 16 1 hunched posture 0.0170749634930786 0.101856047215906 0.881671544316704 0.468354430379747 16.1 16 1 postnatal lethality, incomplete penetrance 1.23041354970923e-09 6.37636188521192e-08 0.881587639525658 0.46830985915493 16.1 16 1 abnormal innervation 0.0576744594747111 0.233235728367449 0.881164545153785 0.468085106382979 16.1 16 1 polyuria 0.0190421911541932 0.111715685132207 0.880124209209093 0.467532467532468 16.1 16 1 epidermal hyperplasia 0.0367071384713664 0.180631072101926 0.87849434956241 0.466666666666667 16.1 16 1 abnormal synaptic transmission 0.118830791754609 0.370700348352211 0.87849434956241 0.466666666666667 16.1 16 1 interdigital webbing 0.237054729506213 0.597743172475119 0.87849434956241 0.466666666666667 16.1 16 1 decreased salivation 0.237054729506213 0.597743172475119 0.87849434956241 0.466666666666667 16.1 16 1 abnormal enteric neuron morphology 0.237054729506213 0.597743172475119 0.87849434956241 0.466666666666667 16.1 16 1 vagina atresia 0.237054729506213 0.597743172475119 0.87849434956241 0.466666666666667 16.1 16 1 hyperpigmentation 0.237054729506213 0.597743172475119 0.87849434956241 0.466666666666667 16.1 16 1 abnormal pup retrieval 0.237054729506213 0.597743172475119 0.87849434956241 0.466666666666667 16.1 16 1 abnormal seizure response to electrical stimulation 0.237054729506213 0.597743172475119 0.87849434956241 0.466666666666667 16.1 16 1 absent egg cylinders 0.237054729506213 0.597743172475119 0.87849434956241 0.466666666666667 16.1 16 1 abnormal bronchus morphology 0.237054729506213 0.597743172475119 0.87849434956241 0.466666666666667 16.1 16 1 joint inflammation 0.237054729506213 0.597743172475119 0.87849434956241 0.466666666666667 16.1 16 1 abnormal cerebral aqueduct morphology 0.237054729506213 0.597743172475119 0.87849434956241 0.466666666666667 16.1 16 1 abnormal microglial cell activation 0.237054729506213 0.597743172475119 0.87849434956241 0.466666666666667 16.1 16 1 decreased trabecular bone mass 0.237054729506213 0.597743172475119 0.87849434956241 0.466666666666667 16.1 16 1 herniated liver 0.237054729506213 0.597743172475119 0.87849434956241 0.466666666666667 16.1 16 1 altered response to myocardial infarction 0.0648196510796155 0.256341624897525 0.87849434956241 0.466666666666667 16.1 16 1 abnormal ovarian follicle morphology 0.0648196510796155 0.256341624897525 0.87849434956241 0.466666666666667 16.1 16 1 hyperglycemia 0.0138767883813438 0.0877217562861313 0.877068222371562 0.465909090909091 16.1 16 1 delayed endochondral bone ossification 0.0728993779027905 0.283560910919767 0.875575763683465 0.465116279069767 16.1 16 1 reddish skin 0.134884700319749 0.398013869567469 0.87401223553403 0.464285714285714 16.1 16 1 abnormal retinal inner nuclear layer morphology 0.134884700319749 0.398013869567469 0.87401223553403 0.464285714285714 16.1 16 1 decreased exploration in new environment 0.0172051356091115 0.102387021118816 0.87401223553403 0.464285714285714 16.1 16 1 increased sensitivity to xenobiotic induced morbidity/mortality 0.00744406745013064 0.0535951310628074 0.872789840799017 0.463636363636364 16.1 16 1 lethality at weaning, incomplete penetrance 0.0820461939556214 0.313984473022474 0.872372437718769 0.463414634146341 16.1 16 1 abnormal neuronal precursor proliferation 0.0515073788926971 0.220182631272341 0.87152217218493 0.462962962962963 16.1 16 1 decreased cardiac muscle contractility 0.0101943166635645 0.0696658315951005 0.868840565501284 0.461538461538462 16.1 16 1 increased thermal nociceptive threshold 0.0155128848420574 0.0938888103275372 0.868840565501284 0.461538461538462 16.1 16 1 abnormal female meiosis 0.0577111922854933 0.233235728367449 0.868840565501284 0.461538461538462 16.1 16 1 abnormal nasal bone morphology 0.153375308030546 0.441319929122015 0.868840565501284 0.461538461538462 16.1 16 1 abnormal xiphoid process morphology 0.153375308030546 0.441319929122015 0.868840565501284 0.461538461538462 16.1 16 1 abnormal Schwann cell morphology 0.153375308030546 0.441319929122015 0.868840565501284 0.461538461538462 16.1 16 1 no spontaneous movement 0.153375308030546 0.441319929122015 0.868840565501284 0.461538461538462 16.1 16 1 abnormal renal/urinary system morphology 0.275961376431384 0.61950452271464 0.868840565501284 0.461538461538462 16.1 16 1 tight skin 0.275961376431384 0.61950452271464 0.868840565501284 0.461538461538462 16.1 16 1 increased synaptic depression 0.275961376431384 0.61950452271464 0.868840565501284 0.461538461538462 16.1 16 1 abnormal soleus morphology 0.275961376431384 0.61950452271464 0.868840565501284 0.461538461538462 16.1 16 1 tracheoesophageal fistula 0.275961376431384 0.61950452271464 0.868840565501284 0.461538461538462 16.1 16 1 abnormal vertebral arch development 0.275961376431384 0.61950452271464 0.868840565501284 0.461538461538462 16.1 16 1 increased circulating ammonia level 0.275961376431384 0.61950452271464 0.868840565501284 0.461538461538462 16.1 16 1 small pituitary gland 0.275961376431384 0.61950452271464 0.868840565501284 0.461538461538462 16.1 16 1 increased prostaglandin level 0.275961376431384 0.61950452271464 0.868840565501284 0.461538461538462 16.1 16 1 decreased cardiac stroke volume 0.275961376431384 0.61950452271464 0.868840565501284 0.461538461538462 16.1 16 1 decreased trabecular bone volume 0.092413810340026 0.342927036753428 0.868840565501284 0.461538461538462 16.1 16 1 increased circulating glucose level 0.00329850544989584 0.0288401838545375 0.867813567196909 0.460992907801418 16.1 16 1 kinked tail 0.0113215762276373 0.0746024393807888 0.867420891374648 0.46078431372549 16.1 16 1 increased circulating aspartate transaminase level 0.0410942099066217 0.191597140076505 0.866542045486731 0.46031746031746 16.1 16 1 increased body length 0.0646909671260774 0.256240096697639 0.865944430282947 0.46 16.1 16 1 decreased width of hypertrophic chondrocyte zone 0.104181057119208 0.370214827977186 0.864926869260288 0.459459459459459 16.1 16 1 abnormal pancreatic beta cell physiology 0.104181057119208 0.370214827977186 0.864926869260288 0.459459459459459 16.1 16 1 abnormal neuromuscular synapse morphology 0.032898036104744 0.164655663602718 0.862806950463081 0.458333333333333 16.1 16 1 abnormal heart left ventricle morphology 0.032898036104744 0.164655663602718 0.862806950463081 0.458333333333333 16.1 16 1 decreased fatty acid level 0.174747523576567 0.491446540301538 0.862806950463081 0.458333333333333 16.1 16 1 impaired fertilization 0.0366700354949218 0.180627155036867 0.860565893448891 0.457142857142857 16.1 16 1 abnormal skeleton development 0.0264127064955008 0.137451061522089 0.859901876555798 0.45679012345679 16.1 16 1 delayed wound healing 0.0814025689995417 0.31200137193584 0.859396646311053 0.456521739130435 16.1 16 1 abnormal circulating amino acid level 0.0573522530204225 0.232162293552971 0.858678687542205 0.456140350877193 16.1 16 1 osteoporosis 0.0913851590760026 0.34053918650594 0.855676314508841 0.454545454545455 16.1 16 1 hypertension 0.0913851590760026 0.34053918650594 0.855676314508841 0.454545454545455 16.1 16 1 increased body size 0.199551919518552 0.538378958570929 0.855676314508841 0.454545454545455 16.1 16 1 increased myocardial infarction size 0.199551919518552 0.538378958570929 0.855676314508841 0.454545454545455 16.1 16 1 abnormal retinal outer plexiform layer morphology 0.199551919518552 0.538378958570929 0.855676314508841 0.454545454545455 16.1 16 1 abnormal basement membrane morphology 0.199551919518552 0.538378958570929 0.855676314508841 0.454545454545455 16.1 16 1 failure of palatal shelf elevation 0.199551919518552 0.538378958570929 0.855676314508841 0.454545454545455 16.1 16 1 abnormal ear position 0.323650302258684 0.61950452271464 0.855676314508841 0.454545454545455 16.1 16 1 premature suture closure 0.323650302258684 0.61950452271464 0.855676314508841 0.454545454545455 16.1 16 1 decreased atrioventricular cushion size 0.323650302258684 0.61950452271464 0.855676314508841 0.454545454545455 16.1 16 1 abnormal sebaceous gland morphology 0.323650302258684 0.61950452271464 0.855676314508841 0.454545454545455 16.1 16 1 social withdrawal 0.323650302258684 0.61950452271464 0.855676314508841 0.454545454545455 16.1 16 1 abnormal food preference 0.323650302258684 0.61950452271464 0.855676314508841 0.454545454545455 16.1 16 1 abnormal hemoglobin 0.323650302258684 0.61950452271464 0.855676314508841 0.454545454545455 16.1 16 1 retinal detachment 0.323650302258684 0.61950452271464 0.855676314508841 0.454545454545455 16.1 16 1 patent ductus arteriosus 0.323650302258684 0.61950452271464 0.855676314508841 0.454545454545455 16.1 16 1 rectal hemorrhage 0.323650302258684 0.61950452271464 0.855676314508841 0.454545454545455 16.1 16 1 abnormal nerve fiber response 0.323650302258684 0.61950452271464 0.855676314508841 0.454545454545455 16.1 16 1 abnormal coronal suture morphology 0.323650302258684 0.61950452271464 0.855676314508841 0.454545454545455 16.1 16 1 increased motor neuron number 0.323650302258684 0.61950452271464 0.855676314508841 0.454545454545455 16.1 16 1 increased glycogen level 0.323650302258684 0.61950452271464 0.855676314508841 0.454545454545455 16.1 16 1 aberrant origin of the right subclavian artery 0.323650302258684 0.61950452271464 0.855676314508841 0.454545454545455 16.1 16 1 increased subcutaneous adipose tissue amount 0.323650302258684 0.61950452271464 0.855676314508841 0.454545454545455 16.1 16 1 dilated heart atrium 0.13278566334624 0.392351057907397 0.855676314508841 0.454545454545455 16.1 16 1 abnormal QRS complex 0.13278566334624 0.392351057907397 0.855676314508841 0.454545454545455 16.1 16 1 alopecia 0.0211020450436335 0.120170661664752 0.852073466868803 0.452631578947368 16.1 16 1 hydronephrosis 0.0291422060027567 0.149210784537041 0.851601665392132 0.452380952380952 16.1 16 1 decreased inflammatory response 0.0291422060027567 0.149210784537041 0.851601665392132 0.452380952380952 16.1 16 1 skin edema 0.102650198380397 0.366082248704282 0.851601665392132 0.452380952380952 16.1 16 1 small cranium 0.150156076564696 0.436602268211201 0.850155822157171 0.451612903225806 16.1 16 1 increased circulating insulin level 0.004376790949691 0.0364732579140917 0.847119551363752 0.45 16.1 16 1 abnormal long bone epiphyseal plate morphology 0.0632516396468877 0.253042965107841 0.847119551363752 0.45 16.1 16 1 abnormal skin pigmentation 0.115373686756995 0.370700348352211 0.847119551363752 0.45 16.1 16 1 abnormal pancreatic beta cell morphology 0.115373686756995 0.370700348352211 0.847119551363752 0.45 16.1 16 1 abnormal basioccipital bone morphology 0.228479021510899 0.587408276686415 0.847119551363752 0.45 16.1 16 1 waved hair 0.228479021510899 0.587408276686415 0.847119551363752 0.45 16.1 16 1 decreased paired-pulse facilitation 0.228479021510899 0.587408276686415 0.847119551363752 0.45 16.1 16 1 abnormal male reproductive system physiology 0.228479021510899 0.587408276686415 0.847119551363752 0.45 16.1 16 1 abnormal optic stalk morphology 0.228479021510899 0.587408276686415 0.847119551363752 0.45 16.1 16 1 kidney atrophy 0.228479021510899 0.587408276686415 0.847119551363752 0.45 16.1 16 1 abnormal long bone hypertrophic chondrocyte zone 0.0898231399720543 0.339825187346745 0.84519864535159 0.448979591836735 16.1 16 1 abnormal outer ear morphology 0.170009101999031 0.47866173313253 0.843873882584581 0.448275862068966 16.1 16 1 enlarged epididymis 0.170009101999031 0.47866173313253 0.843873882584581 0.448275862068966 16.1 16 1 abnormal spatial learning 0.00477639702701805 0.0383267342087336 0.843077399448588 0.447852760736196 16.1 16 1 maternal effect 0.05582656786856 0.228597545420298 0.842905026232589 0.447761194029851 16.1 16 1 seizures 0.0166261148177331 0.0995366079641664 0.842165635858701 0.447368421052632 16.1 16 1 abnormal frontal bone morphology 0.129758024685556 0.38632326320206 0.842165635858701 0.447368421052632 16.1 16 1 abnormal hair follicle morphology 0.0691825825400943 0.27294476458126 0.836661285297533 0.444444444444444 16.1 16 1 abnormal stomach glandular epithelium morphology 0.262408730175746 0.61950452271464 0.836661285297533 0.444444444444444 16.1 16 1 cortical renal glomerulopathies 0.262408730175746 0.61950452271464 0.836661285297533 0.444444444444444 16.1 16 1 delayed kidney development 0.262408730175746 0.61950452271464 0.836661285297533 0.444444444444444 16.1 16 1 decreased heart rate variability 0.262408730175746 0.61950452271464 0.836661285297533 0.444444444444444 16.1 16 1 long tibia 0.262408730175746 0.61950452271464 0.836661285297533 0.444444444444444 16.1 16 1 decreased pulmonary respiratory rate 0.262408730175746 0.61950452271464 0.836661285297533 0.444444444444444 16.1 16 1 abnormal sperm axoneme morphology 0.262408730175746 0.61950452271464 0.836661285297533 0.444444444444444 16.1 16 1 abnormal CNS synaptic transmission 0.0279377303724426 0.144031304251712 0.836661285297533 0.444444444444444 16.1 16 1 polyphagia 0.0879056063002011 0.333839993391985 0.836661285297533 0.444444444444444 16.1 16 1 abnormal trigeminal nerve morphology 0.19275061457489 0.527224643735245 0.836661285297533 0.444444444444444 16.1 16 1 wrinkled skin 0.19275061457489 0.527224643735245 0.836661285297533 0.444444444444444 16.1 16 1 dehydration 0.060872477419532 0.245612794129904 0.833673209278613 0.442857142857143 16.1 16 1 abnormal male meiosis 0.0770220076979259 0.299362881482173 0.833232345603691 0.442622950819672 16.1 16 1 abnormal bone remodeling 0.164478031145912 0.46942039818736 0.83050936408211 0.441176470588235 16.1 16 1 abnormal nervous system electrophysiology 0.0473300214604931 0.211103565539093 0.829191095250234 0.44047619047619 16.1 16 1 decreased acute inflammation 0.218866437208071 0.579489369404019 0.828294672444558 0.44 16.1 16 1 abnormal motor capabilities/coordination/movement 0.0171094398452356 0.101939476922212 0.827153770691879 0.439393939393939 16.1 16 1 increased anxiety-related response 0.0152245684234819 0.0923376955768059 0.826127779907097 0.438848920863309 16.1 16 1 abnormal tooth morphology 0.0834540112193251 0.317418735333442 0.823588452714759 0.4375 16.1 16 1 abnormal hair shaft morphology 0.12235972772553 0.370700348352211 0.823588452714759 0.4375 16.1 16 1 increased circulating follicle stimulating hormone level 0.185394185071038 0.514983847419549 0.823588452714759 0.4375 16.1 16 1 abnormal lymphatic vessel morphology 0.185394185071038 0.514983847419549 0.823588452714759 0.4375 16.1 16 1 absent mandible 0.302483619564316 0.61950452271464 0.823588452714759 0.4375 16.1 16 1 failure of tooth eruption 0.302483619564316 0.61950452271464 0.823588452714759 0.4375 16.1 16 1 vasculature congestion 0.302483619564316 0.61950452271464 0.823588452714759 0.4375 16.1 16 1 mixed cellular infiltration to dermis 0.302483619564316 0.61950452271464 0.823588452714759 0.4375 16.1 16 1 abnormal intestinal absorption 0.302483619564316 0.61950452271464 0.823588452714759 0.4375 16.1 16 1 abnormal extraembryonic endoderm formation 0.302483619564316 0.61950452271464 0.823588452714759 0.4375 16.1 16 1 white spotting 0.302483619564316 0.61950452271464 0.823588452714759 0.4375 16.1 16 1 increased pancreatic beta cell number 0.302483619564316 0.61950452271464 0.823588452714759 0.4375 16.1 16 1 small epididymis 0.302483619564316 0.61950452271464 0.823588452714759 0.4375 16.1 16 1 abnormal wound healing 0.302483619564316 0.61950452271464 0.823588452714759 0.4375 16.1 16 1 abnormal intestinal lipid absorption 0.302483619564316 0.61950452271464 0.823588452714759 0.4375 16.1 16 1 embryonic lethality between somite formation and embryo turning, incomplete penetrance 0.302483619564316 0.61950452271464 0.823588452714759 0.4375 16.1 16 1 abnormal rib morphology 0.0184258216543309 0.108355156891603 0.822716930542574 0.437037037037037 16.1 16 1 abnormal iris morphology 0.15861491758892 0.45534288228787 0.820571645195657 0.435897435897436 16.1 16 1 hyperkeratosis 0.0810653599645828 0.311188399555401 0.818472996486717 0.434782608695652 16.1 16 1 abnormal coat appearance 0.0810653599645828 0.311188399555401 0.818472996486717 0.434782608695652 16.1 16 1 blistering 0.24894188679308 0.616468833646379 0.818472996486717 0.434782608695652 16.1 16 1 abnormal circulating insulin level 0.24894188679308 0.616468833646379 0.818472996486717 0.434782608695652 16.1 16 1 failure of embryo implantation 0.24894188679308 0.616468833646379 0.818472996486717 0.434782608695652 16.1 16 1 abnormal cardiovascular development 0.24894188679308 0.616468833646379 0.818472996486717 0.434782608695652 16.1 16 1 abnormal sacral vertebrae morphology 0.24894188679308 0.616468833646379 0.818472996486717 0.434782608695652 16.1 16 1 abnormal Wolffian duct morphology 0.24894188679308 0.616468833646379 0.818472996486717 0.434782608695652 16.1 16 1 decreased epididymis weight 0.24894188679308 0.616468833646379 0.818472996486717 0.434782608695652 16.1 16 1 increased susceptibility to fungal infection 0.24894188679308 0.616468833646379 0.818472996486717 0.434782608695652 16.1 16 1 abnormal chondrocyte physiology 0.24894188679308 0.616468833646379 0.818472996486717 0.434782608695652 16.1 16 1 short tail 0.0624253775513388 0.251674435427804 0.816500772398797 0.433734939759036 16.1 16 1 abnormal kidney development 0.102962083628864 0.366668837547315 0.815744753165095 0.433333333333333 16.1 16 1 abnormal incisor morphology 0.102962083628864 0.366668837547315 0.815744753165095 0.433333333333333 16.1 16 1 enhanced paired-pulse facilitation 0.209145456891826 0.555228734277926 0.815744753165095 0.433333333333333 16.1 16 1 increased white adipose tissue amount 0.177926203032663 0.494791984397708 0.814048818127329 0.432432432432432 16.1 16 1 increased exploration in new environment 0.068970655097192 0.272324610403595 0.813420694039268 0.432098765432099 16.1 16 1 obese 0.0841316787835573 0.31975179675187 0.806780525108336 0.428571428571429 16.1 16 1 short mandible 0.126979969893434 0.378278652826249 0.806780525108336 0.428571428571429 16.1 16 1 myoclonus 0.236150050266245 0.597743172475119 0.806780525108336 0.428571428571429 16.1 16 1 abnormal respiration 0.236150050266245 0.597743172475119 0.806780525108336 0.428571428571429 16.1 16 1 enhanced coordination 0.236150050266245 0.597743172475119 0.806780525108336 0.428571428571429 16.1 16 1 midline facial cleft 0.350221178523312 0.622935417645147 0.806780525108336 0.428571428571429 16.1 16 1 absent otoliths 0.350221178523312 0.622935417645147 0.806780525108336 0.428571428571429 16.1 16 1 decreased coping response 0.350221178523312 0.622935417645147 0.806780525108336 0.428571428571429 16.1 16 1 absent olfactory bulb 0.350221178523312 0.622935417645147 0.806780525108336 0.428571428571429 16.1 16 1 abnormal voluntary movement 0.350221178523312 0.622935417645147 0.806780525108336 0.428571428571429 16.1 16 1 abnormal sagittal suture morphology 0.350221178523312 0.622935417645147 0.806780525108336 0.428571428571429 16.1 16 1 abnormal pancreas development 0.350221178523312 0.622935417645147 0.806780525108336 0.428571428571429 16.1 16 1 decreased CNS synapse formation 0.350221178523312 0.622935417645147 0.806780525108336 0.428571428571429 16.1 16 1 premature hair loss 0.350221178523312 0.622935417645147 0.806780525108336 0.428571428571429 16.1 16 1 abnormal viscerocranium morphology 0.350221178523312 0.622935417645147 0.806780525108336 0.428571428571429 16.1 16 1 increased lung compliance 0.350221178523312 0.622935417645147 0.806780525108336 0.428571428571429 16.1 16 1 decreased urine osmolality 0.146762168540637 0.426983502040742 0.806780525108335 0.428571428571429 16.1 16 1 small ears 0.283687056798368 0.61950452271464 0.806780525108335 0.428571428571429 16.1 16 1 decreased vocalization 0.283687056798368 0.61950452271464 0.806780525108335 0.428571428571429 16.1 16 1 increased susceptibility to pharmacologically induced seizures 0.0627061386917988 0.25257833325687 0.803979203840598 0.427083333333333 16.1 16 1 abnormal response/metabolism to endogenous compounds 0.0813081115248298 0.311879610513514 0.803500929477814 0.426829268292683 16.1 16 1 abnormal limb morphology 0.0928820051947803 0.343559833341288 0.803194833885632 0.426666666666667 16.1 16 1 abnormal mandible morphology 0.140984646943782 0.414783334444302 0.801800398410136 0.425925925925926 16.1 16 1 abnormal aorta morphology 0.224158358973521 0.587408276686415 0.798631226874918 0.424242424242424 16.1 16 1 absent vibrissae 0.224158358973521 0.587408276686415 0.798631226874918 0.424242424242424 16.1 16 1 abnormal leukocyte cell number 0.266893265271588 0.61950452271464 0.796437185042844 0.423076923076923 16.1 16 1 increased grooming behavior 0.212957605466923 0.564445438038328 0.792626480808189 0.421052631578947 16.1 16 1 abnormal compact bone morphology 0.212957605466923 0.564445438038328 0.792626480808189 0.421052631578947 16.1 16 1 decreased threshold for auditory brainstem response 0.212957605466923 0.564445438038328 0.792626480808189 0.421052631578947 16.1 16 1 stereotypic behavior 0.323969535670561 0.61950452271464 0.792626480808189 0.421052631578947 16.1 16 1 abnormal metatarsal bone morphology 0.323969535670561 0.61950452271464 0.792626480808189 0.421052631578947 16.1 16 1 abnormal optic vesicle formation 0.323969535670561 0.61950452271464 0.792626480808189 0.421052631578947 16.1 16 1 abnormal sternebra morphology 0.323969535670561 0.61950452271464 0.792626480808189 0.421052631578947 16.1 16 1 shortened RR interval 0.323969535670561 0.61950452271464 0.792626480808189 0.421052631578947 16.1 16 1 right-sided stomach 0.323969535670561 0.61950452271464 0.792626480808189 0.421052631578947 16.1 16 1 increased liver weight 0.0915307460238705 0.34053918650594 0.791500590920678 0.420454545454545 16.1 16 1 decreased susceptibility to bacterial infection induced morbidity/mortality 0.251748898239196 0.61950452271464 0.789430406288801 0.419354838709677 16.1 16 1 abnormal organ of Corti morphology 0.202497911590352 0.545144540130952 0.788018187315118 0.418604651162791 16.1 16 1 abnormal axon guidance 0.202497911590352 0.545144540130952 0.788018187315118 0.418604651162791 16.1 16 1 abnormal joint morphology 0.165904723698255 0.46942039818736 0.787222209348133 0.418181818181818 16.1 16 1 abnormal locomotor activation 0.0966161543435346 0.355521721789264 0.786093844977352 0.417582417582418 16.1 16 1 abnormal digit morphology 0.131753035243834 0.392028319580189 0.784369954966437 0.416666666666667 16.1 16 1 abnormal cardiovascular system morphology 0.192719510264689 0.527224643735245 0.784369954966437 0.416666666666667 16.1 16 1 abnormal kidney physiology 0.192719510264689 0.527224643735245 0.784369954966437 0.416666666666667 16.1 16 1 abnormal foregut morphology 0.301937860519161 0.61950452271464 0.784369954966437 0.416666666666667 16.1 16 1 curly vibrissae 0.301937860519161 0.61950452271464 0.784369954966437 0.416666666666667 16.1 16 1 increased stereotypic behavior 0.301937860519161 0.61950452271464 0.784369954966437 0.416666666666667 16.1 16 1 abnormal cardiac muscle contractility 0.301937860519161 0.61950452271464 0.784369954966437 0.416666666666667 16.1 16 1 decreased ovulation rate 0.301937860519161 0.61950452271464 0.784369954966437 0.416666666666667 16.1 16 1 abnormal osteoblast morphology 0.301937860519161 0.61950452271464 0.784369954966437 0.416666666666667 16.1 16 1 hypopigmentation 0.301937860519161 0.61950452271464 0.784369954966437 0.416666666666667 16.1 16 1 increased circulating total protein level 0.301937860519161 0.61950452271464 0.784369954966437 0.416666666666667 16.1 16 1 abnormal adipose tissue distribution 0.407691774189308 0.704993596312759 0.784369954966437 0.416666666666667 16.1 16 1 abnormal pilomotor reflex 0.407691774189308 0.704993596312759 0.784369954966437 0.416666666666667 16.1 16 1 abnormal embryonic growth/weight/body size 0.407691774189308 0.704993596312759 0.784369954966437 0.416666666666667 16.1 16 1 abnormal corticospinal tract morphology 0.407691774189308 0.704993596312759 0.784369954966437 0.416666666666667 16.1 16 1 abnormal AMPA-mediated synaptic currents 0.407691774189308 0.704993596312759 0.784369954966437 0.416666666666667 16.1 16 1 small thyroid gland 0.407691774189308 0.704993596312759 0.784369954966437 0.416666666666667 16.1 16 1 absent tail 0.407691774189308 0.704993596312759 0.784369954966437 0.416666666666667 16.1 16 1 vestibular saccular macula degeneration 0.407691774189308 0.704993596312759 0.784369954966437 0.416666666666667 16.1 16 1 stria vascularis degeneration 0.407691774189308 0.704993596312759 0.784369954966437 0.416666666666667 16.1 16 1 decreased cochlear nerve compound action potential 0.407691774189308 0.704993596312759 0.784369954966437 0.416666666666667 16.1 16 1 small parietal bone 0.407691774189308 0.704993596312759 0.784369954966437 0.416666666666667 16.1 16 1 abnormal anogenital distance 0.407691774189308 0.704993596312759 0.784369954966437 0.416666666666667 16.1 16 1 hemoperitoneum 0.407691774189308 0.704993596312759 0.784369954966437 0.416666666666667 16.1 16 1 impaired behavioral response to cocaine 0.407691774189308 0.704993596312759 0.784369954966437 0.416666666666667 16.1 16 1 abnormal respiratory motile cilium morphology 0.407691774189308 0.704993596312759 0.784369954966437 0.416666666666667 16.1 16 1 abnormal action potential 0.144917160004214 0.42186241721531 0.779887840938058 0.414285714285714 16.1 16 1 deafness 0.0976342060127433 0.359002346573095 0.77961619766361 0.414141414141414 16.1 16 1 short limbs 0.116017923893751 0.370700348352211 0.778960507001152 0.413793103448276 16.1 16 1 abnormal middle ear morphology 0.282837778454867 0.61950452271464 0.778960507001151 0.413793103448276 16.1 16 1 abnormal parietal bone morphology 0.282837778454867 0.61950452271464 0.778960507001151 0.413793103448276 16.1 16 1 decreased retinal photoreceptor cell number 0.282837778454867 0.61950452271464 0.778960507001151 0.413793103448276 16.1 16 1 aphagia 0.282837778454867 0.61950452271464 0.778960507001151 0.413793103448276 16.1 16 1 abnormal forelimb morphology 0.21375769042084 0.566264382238382 0.777549346662381 0.41304347826087 16.1 16 1 abnormal vertebrae morphology 0.0900624536611071 0.340471661826754 0.777173900333718 0.412844036697248 16.1 16 1 decreased susceptibility to injury 0.159312125388576 0.456817189514794 0.775142073143303 0.411764705882353 16.1 16 1 abnormal cued conditioning behavior 0.20301425498696 0.546239004088766 0.775142073143303 0.411764705882353 16.1 16 1 abnormal skin physiology 0.265934588452847 0.61950452271464 0.775142073143303 0.411764705882353 16.1 16 1 abnormal urinary bladder morphology 0.370856307978932 0.656820979777568 0.775142073143303 0.411764705882353 16.1 16 1 abnormal touch/ nociception 0.370856307978932 0.656820979777568 0.775142073143303 0.411764705882353 16.1 16 1 absence seizures 0.370856307978932 0.656820979777568 0.775142073143303 0.411764705882353 16.1 16 1 abnormal duodenum morphology 0.370856307978932 0.656820979777568 0.775142073143303 0.411764705882353 16.1 16 1 abnormal survival 0.370856307978932 0.656820979777568 0.775142073143303 0.411764705882353 16.1 16 1 small lens 0.250761214425533 0.61950452271464 0.77230272489003 0.41025641025641 16.1 16 1 abnormal response to injury 0.250761214425533 0.61950452271464 0.77230272489003 0.41025641025641 16.1 16 1 abnormal circadian rhythm 0.236998008610226 0.597743172475119 0.770108683057957 0.409090909090909 16.1 16 1 abnormal photoreceptor outer segment morphology 0.236998008610226 0.597743172475119 0.770108683057957 0.409090909090909 16.1 16 1 embryonic lethality, incomplete penetrance 0.236998008610226 0.597743172475119 0.770108683057957 0.409090909090909 16.1 16 1 abnormal long bone epiphysis morphology 0.341934459530548 0.61950452271464 0.770108683057957 0.409090909090909 16.1 16 1 increased coping response 0.341934459530548 0.61950452271464 0.770108683057957 0.409090909090909 16.1 16 1 abnormal retinal layer morphology 0.341934459530548 0.61950452271464 0.770108683057957 0.409090909090909 16.1 16 1 abnormal respiratory system physiology 0.224414228695068 0.587408276686415 0.768362404865081 0.408163265306122 16.1 16 1 abnormal axial skeleton morphology 0.159230981069056 0.456817189514794 0.767856903282933 0.407894736842105 16.1 16 1 abnormal trigeminal ganglion morphology 0.317866337625568 0.61950452271464 0.766939511522739 0.407407407407407 16.1 16 1 abnormal single cell response 0.317866337625568 0.61950452271464 0.766939511522739 0.407407407407407 16.1 16 1 abnormal palate morphology 0.317866337625568 0.61950452271464 0.766939511522739 0.407407407407407 16.1 16 1 syndactyly 0.202130082344944 0.544743856807202 0.765757786543505 0.406779661016949 16.1 16 1 abnormal long term potentiation 0.297149491459516 0.61950452271464 0.764760706092276 0.40625 16.1 16 1 abnormal urine homeostasis 0.132764818706002 0.392351057907397 0.764760706092276 0.40625 16.1 16 1 abnormal vocalization 0.278922385973769 0.61950452271464 0.763170766994371 0.405405405405405 16.1 16 1 increased insulin secretion 0.278922385973769 0.61950452271464 0.763170766994371 0.405405405405405 16.1 16 1 pulmonary hypoplasia 0.247926989280431 0.616468833646379 0.761005743541905 0.404255319148936 16.1 16 1 abnormal hair growth 0.234520587793147 0.597409075407531 0.760235494813624 0.403846153846154 16.1 16 1 decreased compact bone thickness 0.200359724029896 0.540265380514219 0.75861452360933 0.402985074626866 16.1 16 1 abnormal excitatory postsynaptic potential 0.172913666854681 0.486564192648213 0.75758659065051 0.402439024390244 16.1 16 1 mandible hypoplasia 0.357318809393222 0.634652294441727 0.75299515676778 0.4 16.1 16 1 abnormal energy expenditure 0.357318809393222 0.634652294441727 0.75299515676778 0.4 16.1 16 1 abnormal social investigation 0.188459323886688 0.523205991259081 0.75299515676778 0.4 16.1 16 1 abnormal heart tube morphology 0.331965992830228 0.61950452271464 0.75299515676778 0.4 16.1 16 1 delayed eyelid opening 0.331965992830228 0.61950452271464 0.75299515676778 0.4 16.1 16 1 abnormal metabolism 0.273720117650764 0.61950452271464 0.75299515676778 0.4 16.1 16 1 lethality at weaning, complete penetrance 0.273720117650764 0.61950452271464 0.75299515676778 0.4 16.1 16 1 abnormal trachea morphology 0.387629878443669 0.675467126184678 0.75299515676778 0.4 16.1 16 1 abnormal lens epithelium morphology 0.387629878443669 0.675467126184678 0.75299515676778 0.4 16.1 16 1 abnormal heart right ventricle morphology 0.387629878443669 0.675467126184678 0.75299515676778 0.4 16.1 16 1 abnormal response to tactile stimuli 0.387629878443669 0.675467126184678 0.75299515676778 0.4 16.1 16 1 enhanced behavioral response to xenobiotic 0.387629878443669 0.675467126184678 0.75299515676778 0.4 16.1 16 1 abnormal heart electrocardiography waveform feature 0.387629878443669 0.675467126184678 0.75299515676778 0.4 16.1 16 1 decreased muscle cell glucose uptake 0.387629878443669 0.675467126184678 0.75299515676778 0.4 16.1 16 1 abnormal fontanelle morphology 0.425665477868044 0.709985664379248 0.75299515676778 0.4 16.1 16 1 no suckling reflex 0.425665477868044 0.709985664379248 0.75299515676778 0.4 16.1 16 1 audiogenic seizures 0.425665477868044 0.709985664379248 0.75299515676778 0.4 16.1 16 1 increased airway responsiveness 0.425665477868044 0.709985664379248 0.75299515676778 0.4 16.1 16 1 abnormal cricoid cartilage morphology 0.425665477868044 0.709985664379248 0.75299515676778 0.4 16.1 16 1 decreased aggression towards males 0.425665477868044 0.709985664379248 0.75299515676778 0.4 16.1 16 1 abnormal rostral migratory stream morphology 0.425665477868044 0.709985664379248 0.75299515676778 0.4 16.1 16 1 abnormal olfactory nerve morphology 0.425665477868044 0.709985664379248 0.75299515676778 0.4 16.1 16 1 abnormal neurotransmitter secretion 0.425665477868044 0.709985664379248 0.75299515676778 0.4 16.1 16 1 abnormal Muller cell morphology 0.425665477868044 0.709985664379248 0.75299515676778 0.4 16.1 16 1 ostium primum atrial septal defect 0.425665477868044 0.709985664379248 0.75299515676778 0.4 16.1 16 1 abnormal branching involved in lung morphogenesis 0.425665477868044 0.709985664379248 0.75299515676778 0.4 16.1 16 1 abnormal excitatory postsynaptic currents 0.205234389600703 0.547149707282516 0.748168264737217 0.397435897435897 16.1 16 1 abnormal coat/ hair morphology 0.267961185451438 0.61950452271464 0.745891428873744 0.39622641509434 16.1 16 1 oligodactyly 0.284097406566608 0.61950452271464 0.745151457218115 0.395833333333333 16.1 16 1 abnormal intestinal mucosa morphology 0.301961644327788 0.61950452271464 0.744239399130945 0.395348837209302 16.1 16 1 abnormal blood circulation 0.301961644327788 0.61950452271464 0.744239399130945 0.395348837209302 16.1 16 1 abnormal trabecular bone morphology 0.157116040684155 0.451300405544845 0.74350362117827 0.394957983193277 16.1 16 1 cleft secondary palate 0.198496972727144 0.536988819639772 0.740979276606592 0.393617021276596 16.1 16 1 abnormal neuron differentiation 0.177465640180047 0.494613561261948 0.739548814682641 0.392857142857143 16.1 16 1 enhanced long term potentiation 0.277182582238269 0.61950452271464 0.739548814682641 0.392857142857143 16.1 16 1 abnormal stria vascularis morphology 0.370741582387484 0.656820979777568 0.739548814682641 0.392857142857143 16.1 16 1 increased food intake 0.219073665954595 0.579729514959634 0.739548814682641 0.392857142857143 16.1 16 1 decreased food intake 0.23047657408882 0.587408276686415 0.738697780373455 0.392405063291139 16.1 16 1 hypotension 0.401715399147491 0.698788150614954 0.736625696838045 0.391304347826087 16.1 16 1 abnormal hepatocyte physiology 0.401715399147491 0.698788150614954 0.736625696838045 0.391304347826087 16.1 16 1 abnormal thoracic vertebrae morphology 0.285938847872561 0.61950452271464 0.733851212104192 0.389830508474576 16.1 16 1 short radius 0.356014888889222 0.632788164424394 0.732078624635342 0.388888888888889 16.1 16 1 absent spleen 0.439868402944596 0.722703204970068 0.732078624635342 0.388888888888889 16.1 16 1 atrioventricular block 0.439868402944596 0.722703204970068 0.732078624635342 0.388888888888889 16.1 16 1 abnormal long bone epiphyseal plate proliferative zone 0.303040569644139 0.61950452271464 0.732078624635341 0.388888888888889 16.1 16 1 abnormal nose morphology 0.382629420992984 0.669724666924667 0.728704990420432 0.387096774193548 16.1 16 1 short femur 0.250716900700644 0.61950452271464 0.727324867332515 0.386363636363636 16.1 16 1 abnormal ureter morphology 0.413834774469242 0.709985664379248 0.724033804584404 0.384615384615385 16.1 16 1 small seminal vesicle 0.413834774469242 0.709985664379248 0.724033804584404 0.384615384615385 16.1 16 1 increased susceptibility to otitis media 0.413834774469242 0.709985664379248 0.724033804584404 0.384615384615385 16.1 16 1 abnormal ocular fundus morphology 0.413834774469242 0.709985664379248 0.724033804584404 0.384615384615385 16.1 16 1 short premaxilla 0.490023272788011 0.784636556845946 0.724033804584404 0.384615384615385 16.1 16 1 absent trabeculae carneae 0.490023272788011 0.784636556845946 0.724033804584404 0.384615384615385 16.1 16 1 dystrophic cardiac calcinosis 0.490023272788011 0.784636556845946 0.724033804584404 0.384615384615385 16.1 16 1 anal atresia 0.490023272788011 0.784636556845946 0.724033804584404 0.384615384615385 16.1 16 1 abnormal afterhyperpolarization 0.490023272788011 0.784636556845946 0.724033804584404 0.384615384615385 16.1 16 1 muscle fatigue 0.490023272788011 0.784636556845946 0.724033804584404 0.384615384615385 16.1 16 1 small otic vesicle 0.490023272788011 0.784636556845946 0.724033804584404 0.384615384615385 16.1 16 1 small interparietal bone 0.490023272788011 0.784636556845946 0.724033804584404 0.384615384615385 16.1 16 1 hyperalgesia 0.490023272788011 0.784636556845946 0.724033804584404 0.384615384615385 16.1 16 1 empty decidua capsularis 0.490023272788011 0.784636556845946 0.724033804584404 0.384615384615385 16.1 16 1 abnormal lens fiber morphology 0.366431445358998 0.650605439208071 0.724033804584403 0.384615384615385 16.1 16 1 abnormal inhibitory postsynaptic currents 0.309807827947117 0.61950452271464 0.719774782204495 0.382352941176471 16.1 16 1 abnormal vision 0.393287480365573 0.684606443253577 0.719774782204495 0.382352941176471 16.1 16 1 increased width of hypertrophic chondrocyte zone 0.393287480365573 0.684606443253577 0.719774782204495 0.382352941176471 16.1 16 1 decreased osteoblast cell number 0.393287480365573 0.684606443253577 0.719774782204495 0.382352941176471 16.1 16 1 abnormal optic nerve morphology 0.37600025695256 0.665694405102843 0.717138244540743 0.380952380952381 16.1 16 1 abnormal scapula morphology 0.451594691763855 0.740990630450257 0.717138244540743 0.380952380952381 16.1 16 1 abnormal associative learning 0.451594691763855 0.740990630450257 0.717138244540743 0.380952380952381 16.1 16 1 decreased cochlear outer hair cell number 0.451594691763855 0.740990630450257 0.717138244540743 0.380952380952381 16.1 16 1 abnormal eye electrophysiology 0.248563121983106 0.616468833646379 0.715656553952849 0.380165289256198 16.1 16 1 short sternum 0.424460573679638 0.709985664379248 0.714047131417722 0.379310344827586 16.1 16 1 abnormal tail morphology 0.335244640325767 0.61950452271464 0.713063595424034 0.378787878787879 16.1 16 1 abnormal breathing pattern 0.402940760229063 0.700429867973301 0.712292715861413 0.378378378378378 16.1 16 1 impaired skeletal muscle contractility 0.402940760229063 0.700429867973301 0.712292715861413 0.378378378378378 16.1 16 1 abnormal long bone morphology 0.355058107060465 0.631313110302293 0.709790516625366 0.377049180327869 16.1 16 1 circling 0.319970074827222 0.61950452271464 0.708701324016734 0.376470588235294 16.1 16 1 abnormal lumbar vertebrae morphology 0.433917378713065 0.713632713751239 0.705932959469794 0.375 16.1 16 1 delayed hair appearance 0.499574592850281 0.795832084351632 0.705932959469794 0.375 16.1 16 1 paternal imprinting 0.499574592850281 0.795832084351632 0.705932959469794 0.375 16.1 16 1 abnormal pulmonary elastic fiber morphology 0.499574592850281 0.795832084351632 0.705932959469794 0.375 16.1 16 1 decreased aggression towards mice 0.499574592850281 0.795832084351632 0.705932959469794 0.375 16.1 16 1 abnormal molar crown morphology 0.499574592850281 0.795832084351632 0.705932959469794 0.375 16.1 16 1 bowed radius 0.499574592850281 0.795832084351632 0.705932959469794 0.375 16.1 16 1 abnormal epididymis epithelium morphology 0.499574592850281 0.795832084351632 0.705932959469794 0.375 16.1 16 1 increased circulating estradiol level 0.499574592850281 0.795832084351632 0.705932959469794 0.375 16.1 16 1 abnormal fertilization 0.499574592850281 0.795832084351632 0.705932959469794 0.375 16.1 16 1 impaired behavioral response to addictive substance 0.499574592850281 0.795832084351632 0.705932959469794 0.375 16.1 16 1 decreased skeletal muscle weight 0.499574592850281 0.795832084351632 0.705932959469794 0.375 16.1 16 1 decreased midbrain size 0.499574592850281 0.795832084351632 0.705932959469794 0.375 16.1 16 1 decreased adipocyte glucose uptake 0.499574592850281 0.795832084351632 0.705932959469794 0.375 16.1 16 1 abnormal body weight 0.461581922324489 0.746787012541246 0.705932959469794 0.375 16.1 16 1 abnormal femur morphology 0.369142915553192 0.655185874019669 0.702420855193824 0.373134328358209 16.1 16 1 decreased susceptibility to pharmacologically induced seizures 0.470286796141992 0.760623150457221 0.697217737747944 0.37037037037037 16.1 16 1 impaired branching involved in ureteric bud morphogenesis 0.450189514946032 0.739416585294324 0.693548170707166 0.368421052631579 16.1 16 1 abnormal nail morphology 0.507476075521116 0.803929301349485 0.693548170707166 0.368421052631579 16.1 16 1 decreased grooming behavior 0.507476075521116 0.803929301349485 0.693548170707166 0.368421052631579 16.1 16 1 abnormal response to novelty 0.507476075521116 0.803929301349485 0.693548170707166 0.368421052631579 16.1 16 1 increased left ventricle weight 0.507476075521116 0.803929301349485 0.693548170707166 0.368421052631579 16.1 16 1 abnormal behavioral response to xenobiotic 0.507476075521116 0.803929301349485 0.693548170707166 0.368421052631579 16.1 16 1 decreased liver glycogen level 0.507476075521116 0.803929301349485 0.693548170707166 0.368421052631579 16.1 16 1 thin interventricular septum 0.507476075521116 0.803929301349485 0.693548170707166 0.368421052631579 16.1 16 1 abnormal eye physiology 0.421128131209914 0.709985664379248 0.690245560370465 0.366666666666667 16.1 16 1 short humerus 0.457304332499771 0.745520044266342 0.688715082409555 0.365853658536585 16.1 16 1 palatal shelves fail to meet at midline 0.457304332499771 0.745520044266342 0.688715082409555 0.365853658536585 16.1 16 1 abnormal basisphenoid bone morphology 0.51425768161146 0.803929301349485 0.684541051607073 0.363636363636364 16.1 16 1 intestinal ulcer 0.51425768161146 0.803929301349485 0.684541051607073 0.363636363636364 16.1 16 1 decreased airway responsiveness 0.51425768161146 0.803929301349485 0.684541051607073 0.363636363636364 16.1 16 1 abnormal channel response 0.51425768161146 0.803929301349485 0.684541051607073 0.363636363636364 16.1 16 1 cleft upper lip 0.51425768161146 0.803929301349485 0.684541051607073 0.363636363636364 16.1 16 1 abnormal temporal bone morphology 0.51425768161146 0.803929301349485 0.684541051607073 0.363636363636364 16.1 16 1 abnormal food intake 0.438460299247549 0.720865825762247 0.682060830405598 0.36231884057971 16.1 16 1 abnormal limb bone morphology 0.491284021924653 0.785896465940562 0.679787294304246 0.361111111111111 16.1 16 1 renal hypoplasia 0.491284021924653 0.785896465940562 0.679787294304246 0.361111111111111 16.1 16 1 head tilt 0.491284021924653 0.785896465940562 0.679787294304246 0.361111111111111 16.1 16 1 abnormal feces composition 0.520229923348327 0.803929301349485 0.677695641091002 0.36 16.1 16 1 abnormal cartilage morphology 0.502473263359332 0.799937435268057 0.672317104256946 0.357142857142857 16.1 16 1 abnormal vibrissa morphology 0.502473263359332 0.799937435268057 0.672317104256946 0.357142857142857 16.1 16 1 abnormal vasoconstriction 0.567691102935066 0.803929301349485 0.672317104256946 0.357142857142857 16.1 16 1 absent atrioventricular cushions 0.567691102935066 0.803929301349485 0.672317104256946 0.357142857142857 16.1 16 1 abnormal jaw morphology 0.525589692672275 0.803929301349485 0.672317104256946 0.357142857142857 16.1 16 1 abnormal placing response 0.567691102935066 0.803929301349485 0.672317104256946 0.357142857142857 16.1 16 1 absent corpus callosum 0.525589692672275 0.803929301349485 0.672317104256946 0.357142857142857 16.1 16 1 abnormal imprinting 0.567691102935066 0.803929301349485 0.672317104256946 0.357142857142857 16.1 16 1 abnormal hair cuticle 0.567691102935066 0.803929301349485 0.672317104256946 0.357142857142857 16.1 16 1 abnormal squamosal bone morphology 0.567691102935066 0.803929301349485 0.672317104256946 0.357142857142857 16.1 16 1 decreased circulating progesterone level 0.525589692672275 0.803929301349485 0.672317104256946 0.357142857142857 16.1 16 1 decreased tongue size 0.567691102935066 0.803929301349485 0.672317104256946 0.357142857142857 16.1 16 1 abnormal renal reabsorbtion 0.567691102935066 0.803929301349485 0.672317104256946 0.357142857142857 16.1 16 1 abnormal renal tubule epithelial cell primary cilium morphology 0.567691102935066 0.803929301349485 0.672317104256946 0.357142857142857 16.1 16 1 decreased neuronal precursor cell number 0.530469423630057 0.803929301349485 0.667979574552063 0.354838709677419 16.1 16 1 abnormal phalanx morphology 0.512185842238066 0.803929301349485 0.666714461721472 0.354166666666667 16.1 16 1 increased aggression towards mice 0.569784566416471 0.803929301349485 0.664407491265688 0.352941176470588 16.1 16 1 abnormal heart rate 0.569784566416471 0.803929301349485 0.664407491265688 0.352941176470588 16.1 16 1 abnormal cranial suture morphology 0.569784566416471 0.803929301349485 0.664407491265688 0.352941176470588 16.1 16 1 nephrocalcinosis 0.569784566416471 0.803929301349485 0.664407491265688 0.352941176470588 16.1 16 1 common atrium 0.569784566416471 0.803929301349485 0.664407491265688 0.352941176470588 16.1 16 1 decreased body fat mass 0.569784566416471 0.803929301349485 0.664407491265688 0.352941176470588 16.1 16 1 abnormal cell cytoskeleton morphology 0.569784566416471 0.803929301349485 0.664407491265688 0.352941176470588 16.1 16 1 abnormal hearing physiology 0.572008643178204 0.803929301349485 0.658870762171807 0.35 16.1 16 1 abnormal hyoid bone morphology 0.572008643178204 0.803929301349485 0.658870762171807 0.35 16.1 16 1 increased susceptibility to weight loss 0.543043436516727 0.803929301349485 0.658870762171807 0.35 16.1 16 1 abnormal cochlear ganglion morphology 0.57428023225891 0.804574529847389 0.654778397189374 0.347826086956522 16.1 16 1 abnormal basicranium morphology 0.57428023225891 0.804574529847389 0.654778397189374 0.347826086956522 16.1 16 1 abnormal stomach morphology 0.576556766872548 0.807536575222671 0.651630424125963 0.346153846153846 16.1 16 1 focal hair loss 0.578815544773663 0.810016128058783 0.649133755834293 0.344827586206897 16.1 16 1 stomach inflammation 0.578815544773663 0.810016128058783 0.649133755834293 0.344827586206897 16.1 16 1 absent long term depression 0.578815544773663 0.810016128058783 0.649133755834293 0.344827586206897 16.1 16 1 short ulna 0.587500749710704 0.821939322218997 0.642800743582251 0.341463414634146 16.1 16 1 abnormal tibia morphology 0.591601564320949 0.827443852262221 0.640846941930025 0.340425531914894 16.1 16 1 abnormal radius morphology 0.634742648152409 0.884302625191328 0.62749596397315 0.333333333333333 16.1 16 1 blepharoptosis 0.634742648152409 0.884302625191328 0.62749596397315 0.333333333333333 16.1 16 1 abnormal thyroid cartilage morphology 0.634742648152409 0.884302625191328 0.62749596397315 0.333333333333333 16.1 16 1 decreased activity of thyroid 0.634742648152409 0.884302625191328 0.62749596397315 0.333333333333333 16.1 16 1 absent ureter 0.634742648152409 0.884302625191328 0.62749596397315 0.333333333333333 16.1 16 1 abnormal anterior eye segment morphology 0.634742648152409 0.884302625191328 0.62749596397315 0.333333333333333 16.1 16 1 abnormal estrous cycle 0.629218283232689 0.879314876146805 0.62749596397315 0.333333333333333 16.1 16 1 single kidney 0.629086723912574 0.879314876146805 0.62749596397315 0.333333333333333 16.1 16 1 head tossing 0.629086723912574 0.879314876146805 0.62749596397315 0.333333333333333 16.1 16 1 cryptorchism 0.629691752237825 0.879729420775956 0.62749596397315 0.333333333333333 16.1 16 1 increased circulating corticosterone level 0.630613684983414 0.880544822186347 0.62749596397315 0.333333333333333 16.1 16 1 abnormal retinal ganglion layer morphology 0.630629387226121 0.880544822186347 0.62749596397315 0.333333333333333 16.1 16 1 increased vasoconstriction 0.632215618885377 0.882264433086887 0.62749596397315 0.333333333333333 16.1 16 1 increased bone ossification 0.632215618885377 0.882264433086887 0.62749596397315 0.333333333333333 16.1 16 1 absent incisors 0.638703915468577 0.888328761379975 0.62749596397315 0.333333333333333 16.1 16 1 abnormal apical ectodermal ridge morphology 0.638703915468577 0.888328761379975 0.62749596397315 0.333333333333333 16.1 16 1 dilated ureter 0.638703915468577 0.888328761379975 0.62749596397315 0.333333333333333 16.1 16 1 abnormal ear development 0.638703915468577 0.888328761379975 0.62749596397315 0.333333333333333 16.1 16 1 abnormal aorta wall morphology 0.638703915468577 0.888328761379975 0.62749596397315 0.333333333333333 16.1 16 1 lactation failure 0.638703915468577 0.888328761379975 0.62749596397315 0.333333333333333 16.1 16 1 impaired ovarian folliculogenesis 0.671181544739313 0.915963349201376 0.611808564873821 0.325 16.1 16 1 head bobbing 0.671181544739313 0.915963349201376 0.611808564873821 0.325 16.1 16 1 abnormal humerus morphology 0.67244939915323 0.915963349201376 0.610536613595497 0.324324324324324 16.1 16 1 abnormal retinal photoreceptor morphology 0.674102721256719 0.915963349201376 0.609040200326881 0.323529411764706 16.1 16 1 decreased pancreatic beta cell number 0.674102721256719 0.915963349201376 0.609040200326881 0.323529411764706 16.1 16 1 abnormal body temperature homeostasis 0.676241549710132 0.917203301474347 0.607254158683693 0.32258064516129 16.1 16 1 increased circulating luteinizing hormone level 0.679003254137296 0.920698061960493 0.605085393831252 0.321428571428571 16.1 16 1 abnormal inner ear vestibule morphology 0.682582076109789 0.92479461564439 0.602396125414224 0.32 16.1 16 1 abnormal nest building behavior 0.682582076109789 0.92479461564439 0.602396125414224 0.32 16.1 16 1 increased liver glycogen level 0.682582076109789 0.92479461564439 0.602396125414224 0.32 16.1 16 1 increased systemic arterial blood pressure 0.706046281736375 0.933014757073548 0.600794008059399 0.319148936170213 16.1 16 1 abnormal cochlear sensory epithelium morphology 0.687262656279872 0.930882579633096 0.598973420156188 0.318181818181818 16.1 16 1 flaky skin 0.693481066289928 0.933014757073548 0.594469860606142 0.315789473684211 16.1 16 1 abnormal ear morphology 0.693481066289928 0.933014757073548 0.594469860606142 0.315789473684211 16.1 16 1 abnormal neurotransmitter level 0.693481066289928 0.933014757073548 0.594469860606142 0.315789473684211 16.1 16 1 maternal imprinting 0.693481066289928 0.933014757073548 0.594469860606142 0.315789473684211 16.1 16 1 impaired behavioral response to xenobiotic 0.715749713744056 0.933014757073548 0.591639051746113 0.314285714285714 16.1 16 1 disorganized retinal layers 0.701944516658712 0.933014757073548 0.588277466224828 0.3125 16.1 16 1 bowed tibia 0.701944516658712 0.933014757073548 0.588277466224828 0.3125 16.1 16 1 decreased circulating prolactin level 0.701944516658712 0.933014757073548 0.588277466224828 0.3125 16.1 16 1 abnormal serotonin level 0.719513024896164 0.933014757073548 0.588277466224828 0.3125 16.1 16 1 abnormal urinary bladder physiology 0.701944516658712 0.933014757073548 0.588277466224828 0.3125 16.1 16 1 abnormal autopod morphology 0.74274924651674 0.954579566370649 0.585662899708273 0.311111111111111 16.1 16 1 increased percent body fat/body weight 0.768282512077525 0.980052691688638 0.579227043667523 0.307692307692308 16.1 16 1 bidirectional circling 0.736692466789042 0.947040057435526 0.572931097540702 0.304347826086957 16.1 16 1 abnormal ulna morphology 0.736692466789042 0.947040057435526 0.572931097540702 0.304347826086957 16.1 16 1 abnormal inner ear morphology 0.774786441651527 0.985317624544056 0.572931097540702 0.304347826086957 16.1 16 1 abnormal middle ear ossicle morphology 0.758828807932507 0.970936444139558 0.570450876339227 0.303030303030303 16.1 16 1 decreased skin tensile strength 0.745540676194953 0.957425106884329 0.564746367575835 0.3 16.1 16 1 abnormal incus morphology 0.745540676194953 0.957425106884329 0.564746367575835 0.3 16.1 16 1 nuclear cataracts 0.745540676194953 0.957425106884329 0.564746367575835 0.3 16.1 16 1 hydroureter 0.757011162592978 0.970936444139558 0.553672909388073 0.294117647058824 16.1 16 1 enlarged sebaceous gland 0.757011162592978 0.970936444139558 0.553672909388073 0.294117647058824 16.1 16 1 abnormal tarsal bone morphology 0.757011162592978 0.970936444139558 0.553672909388073 0.294117647058824 16.1 16 1 decreased growth hormone level 0.757011162592978 0.970936444139558 0.553672909388073 0.294117647058824 16.1 16 1 overexpanded pulmonary alveoli 0.794131344047419 1 0.553672909388073 0.294117647058824 16.1 16 1 abnormal retinal outer nuclear layer morphology 0.819064025058003 1 0.54493070555563 0.289473684210526 16.1 16 1 hypoalgesia 0.790870699118783 1 0.537853683405557 0.285714285714286 16.1 16 1 abnormal cochlea morphology 0.888730643993489 1 0.522913303310958 0.277777777777778 16.1 16 1 abnormal systemic arterial blood pressure 0.853044784784753 1 0.522913303310958 0.277777777777778 16.1 16 1 abnormal reflex 0.853044784784753 1 0.522913303310958 0.277777777777778 16.1 16 1 abnormal tracheal cartilage morphology 0.829723715183375 1 0.513405788705304 0.272727272727273 16.1 16 1 decreased cardiac output 0.829723715183375 1 0.513405788705304 0.272727272727273 16.1 16 1 increased circulating creatine kinase level 0.829723715183375 1 0.513405788705304 0.272727272727273 16.1 16 1 emphysema 0.869089165994386 1 0.50199677117852 0.266666666666667 16.1 16 1 abnormal pain threshold 0.869089165994386 1 0.50199677117852 0.266666666666667 16.1 16 1 abnormal photoreceptor inner segment morphology 0.84352196001909 1 0.495391550505118 0.263157894736842 16.1 16 1 increased susceptibility to age related obesity 0.862558273440198 1 0.49108379789203 0.260869565217391 16.1 16 1 abnormal hindlimb morphology 0.928076425665407 1 0.489446851899057 0.26 16.1 16 1 abnormal digestive system physiology 0.928076425665407 1 0.489446851899057 0.26 16.1 16 1 abnormal cranial ganglia morphology 0.892788895631258 1 0.485803326946955 0.258064516129032 16.1 16 1 abnormal malleus morphology 0.889955864736849 1 0.470621972979862 0.25 16.1 16 1 increased dopamine level 0.91277851357845 1 0.470621972979862 0.25 16.1 16 1 apnea 0.889955864736849 1 0.470621972979862 0.25 16.1 16 1 abnormal cartilage development 0.948960362703091 1 0.460163706913643 0.244444444444444 16.1 16 1 abnormal vertebrae development 0.912554857882035 1 0.451797094060668 0.24 16.1 16 1 abnormal stomach mucosa morphology 0.912554857882035 1 0.451797094060668 0.24 16.1 16 1 abnormal carpal bone morphology 0.941511498750276 1 0.409236498243359 0.217391304347826 16.1 16 1 abnormal crista ampullaris morphology 0.941511498750276 1 0.409236498243359 0.217391304347826 16.1 16 1 impaired conditioned place preference behavior 0.965709749103332 1 0.37649757838389 0.2 16.1 16 1 abnormal tectorial membrane morphology 0.973973678206335 1 0.362016902292202 0.192307692307692 16.1 16 1 decreased DN2 thymocyte number 4.65377403897466e-05 0.000972795203525165 3.15684352407793 1 16.3 16 3 enlarged axillary lymph nodes 0.000804965719616749 0.0107077659227094 3.15684352407793 1 16.3 16 3 decreased pre-pro B cell number 0.000804965719616749 0.0107077659227094 3.15684352407793 1 16.3 16 3 decreased red blood cell distribution width 1.45374316341946e-06 4.82158149200786e-05 2.89377323040477 0.916666666666667 16.3 16 3 decreased macrophage cytokine production 2.1076821998204e-05 0.000496953504460023 2.84115917167014 0.9 16.3 16 3 mammary gland hyperplasia 0.00107568092121467 0.0135481331216279 2.70586587778108 0.857142857142857 16.3 16 3 decreased DN4 thymocyte number 0.00107568092121467 0.0135481331216279 2.70586587778108 0.857142857142857 16.3 16 3 abnormal conotruncal ridge morphology 0.00107568092121467 0.0135481331216279 2.70586587778108 0.857142857142857 16.3 16 3 embryo tumor 0.00107568092121467 0.0135481331216279 2.70586587778108 0.857142857142857 16.3 16 3 embryonic lethality between implantation and placentation, incomplete penetrance 2.60754668299061e-05 0.000589661124903558 2.63070293673161 0.833333333333333 16.3 16 3 abnormal lymph node cortex morphology 0.00386200334373396 0.0385659816812626 2.63070293673161 0.833333333333333 16.3 16 3 impaired granulocyte bactericidal activity 0.00386200334373396 0.0385659816812626 2.63070293673161 0.833333333333333 16.3 16 3 osteomyelitis 0.00386200334373396 0.0385659816812626 2.63070293673161 0.833333333333333 16.3 16 3 abnormal placenta size 8.01781138095834e-06 0.00021797055530201 2.52547481926235 0.8 16.3 16 3 increased heart rate variability 0.000311579836581064 0.00485927801564512 2.52547481926235 0.8 16.3 16 3 abnormal left subclavian artery morphology 0.000311579836581064 0.00485927801564512 2.52547481926235 0.8 16.3 16 3 abnormal B cell proliferation 0.00028543113552976 0.00453680478996982 2.36763264305845 0.75 16.3 16 3 abnormal cellular cholesterol metabolism 0.00342076922127764 0.0348023044496038 2.36763264305845 0.75 16.3 16 3 liver failure 0.00342076922127764 0.0348023044496038 2.36763264305845 0.75 16.3 16 3 abnormal eyelid aperture 0.00342076922127764 0.0348023044496038 2.36763264305845 0.75 16.3 16 3 abnormal extraembryonic tissue physiology 0.00342076922127764 0.0348023044496038 2.36763264305845 0.75 16.3 16 3 abnormal somite size 0.00342076922127764 0.0348023044496038 2.36763264305845 0.75 16.3 16 3 pleural effusion 0.00342076922127764 0.0348023044496038 2.36763264305845 0.75 16.3 16 3 decreased B-1 B cell number 4.99670651631911e-11 4.2743855043556e-09 2.34739646662205 0.743589743589744 16.3 16 3 abnormal dendritic cell morphology 7.86503552574558e-05 0.00156514206962337 2.31501858432382 0.733333333333333 16.3 16 3 decreased B cell proliferation 2.50933729071542e-19 8.32263534753947e-17 2.27772254268914 0.721518987341772 16.3 16 3 abnormal spleen periarteriolar lymphoid sheath morphology 0.000242341196257429 0.00398071965267491 2.25488823148424 0.714285714285714 16.3 16 3 increased B-1 B cell number 0.000242341196257429 0.00398071965267491 2.25488823148424 0.714285714285714 16.3 16 3 decreased CNS synapse formation 0.000242341196257429 0.00398071965267491 2.25488823148424 0.714285714285714 16.3 16 3 multiple persisting craniopharyngeal ducts 0.000242341196257429 0.00398071965267491 2.25488823148424 0.714285714285714 16.3 16 3 decreased response to antigen 0.000242341196257429 0.00398071965267491 2.25488823148424 0.714285714285714 16.3 16 3 cellular necrosis 0.0108278094000322 0.08674452780219 2.25488823148424 0.714285714285714 16.3 16 3 broad head 0.0108278094000322 0.08674452780219 2.25488823148424 0.714285714285714 16.3 16 3 abnormal oculomotor nerve morphology 0.0108278094000322 0.08674452780219 2.25488823148424 0.714285714285714 16.3 16 3 abnormal circulating free fatty acids level 0.0108278094000322 0.08674452780219 2.25488823148424 0.714285714285714 16.3 16 3 abnormal gastrulation movements 0.0108278094000322 0.08674452780219 2.25488823148424 0.714285714285714 16.3 16 3 abnormal lymph node primary follicle morphology 0.0108278094000322 0.08674452780219 2.25488823148424 0.714285714285714 16.3 16 3 decreased cardiomyocyte apoptosis 0.0108278094000322 0.08674452780219 2.25488823148424 0.714285714285714 16.3 16 3 aorta coarctation 0.0108278094000322 0.08674452780219 2.25488823148424 0.714285714285714 16.3 16 3 increased chronic myelocytic leukemia incidence 0.0108278094000322 0.08674452780219 2.25488823148424 0.714285714285714 16.3 16 3 decreased tidal volume 0.0108278094000322 0.08674452780219 2.25488823148424 0.714285714285714 16.3 16 3 absent popliteal lymph nodes 0.0108278094000322 0.08674452780219 2.25488823148424 0.714285714285714 16.3 16 3 arteritis 0.0108278094000322 0.08674452780219 2.25488823148424 0.714285714285714 16.3 16 3 decreased T-helper 17 cell number 0.0108278094000322 0.08674452780219 2.25488823148424 0.714285714285714 16.3 16 3 abnormal immune cell physiology 0.00275901607521046 0.029904368135451 2.20979046685455 0.7 16.3 16 3 osteosclerosis 0.00275901607521046 0.029904368135451 2.20979046685455 0.7 16.3 16 3 absent inguinal lymph nodes 0.00275901607521046 0.029904368135451 2.20979046685455 0.7 16.3 16 3 decreased transitional stage T2 B cell number 0.00275901607521046 0.029904368135451 2.20979046685455 0.7 16.3 16 3 increased circulating fructosamine level 0.00275901607521046 0.029904368135451 2.20979046685455 0.7 16.3 16 3 abnormal hematopoietic stem cell physiology 5.10515886815606e-06 0.000144307757778843 2.19606506022813 0.695652173913043 16.3 16 3 absent hypoglossal nerve 0.000728703562925475 0.00995961600426988 2.18550705513088 0.692307692307692 16.3 16 3 decreased granulocyte number 4.03605131375674e-07 1.58105159731809e-05 2.17713346488133 0.689655172413793 16.3 16 3 failure of tooth eruption 0.000196693710560542 0.0033977472570788 2.17032992280358 0.6875 16.3 16 3 decreased fibroblast apoptosis 0.000196693710560542 0.0033977472570788 2.17032992280358 0.6875 16.3 16 3 increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 5.38729713688045e-05 0.00110972478952335 2.15994556910595 0.684210526315789 16.3 16 3 increased skin papilloma incidence 1.49107305515172e-05 0.000363631786734304 2.15239331187132 0.681818181818182 16.3 16 3 osteopetrosis 3.2926262964659e-07 1.34268982171458e-05 2.13850690340763 0.67741935483871 16.3 16 3 abnormal placenta vasculature 5.06912049762774e-11 4.2743855043556e-09 2.12479852582169 0.673076923076923 16.3 16 3 abnormal thymus medulla morphology 0.000155090260185021 0.00282627855099077 2.10456234938529 0.666666666666667 16.3 16 3 decreased cellular sensitivity to gamma-irradiation 0.000155090260185021 0.00282627855099077 2.10456234938529 0.666666666666667 16.3 16 3 abnormal hypoglossal nerve topology 0.000155090260185021 0.00282627855099077 2.10456234938529 0.666666666666667 16.3 16 3 interstitial pneumonia 0.00212920085929322 0.0239927106375019 2.10456234938529 0.666666666666667 16.3 16 3 abnormal defecation 0.00212920085929322 0.0239927106375019 2.10456234938529 0.666666666666667 16.3 16 3 abnormal thymus corticomedullary boundary morphology 0.00212920085929322 0.0239927106375019 2.10456234938529 0.666666666666667 16.3 16 3 abnormal thymus lobule morphology 0.00817068624749315 0.0688968882733533 2.10456234938529 0.666666666666667 16.3 16 3 abnormal posterior semicircular canal morphology 0.00817068624749315 0.0688968882733533 2.10456234938529 0.666666666666667 16.3 16 3 decreased fear-related response 0.00817068624749315 0.0688968882733533 2.10456234938529 0.666666666666667 16.3 16 3 absent cervical lymph nodes 0.00817068624749315 0.0688968882733533 2.10456234938529 0.666666666666667 16.3 16 3 decreased transitional stage T1 B cell number 0.00817068624749315 0.0688968882733533 2.10456234938529 0.666666666666667 16.3 16 3 decreased effector memory CD4-positive, alpha-beta T cell number 0.00817068624749315 0.0688968882733533 2.10456234938529 0.666666666666667 16.3 16 3 increased myeloid cell number 0.00817068624749315 0.0688968882733533 2.10456234938529 0.666666666666667 16.3 16 3 abnormal ductus venosus valve topology 0.00817068624749315 0.0688968882733533 2.10456234938529 0.666666666666667 16.3 16 3 symmetric azygos veins 0.00817068624749315 0.0688968882733533 2.10456234938529 0.666666666666667 16.3 16 3 abnormal microglial cell activation 0.000569722878257374 0.00805219124809783 2.10456234938529 0.666666666666667 16.3 16 3 abnormal embryonic erythropoiesis 2.61873246440574e-06 8.24569241165733e-05 2.06827679163727 0.655172413793103 16.3 16 3 abnormal Peyer's patch T cell area morphology 0.000119904420774512 0.00227681104333281 2.05194829065066 0.65 16.3 16 3 decreased susceptibility to induced arthritis 7.20792442342352e-11 5.78377806556968e-09 2.04917912966462 0.649122807017544 16.3 16 3 increased lactate dehydrogenase level 0.00160415582292796 0.0189115526518166 2.02939940833581 0.642857142857143 16.3 16 3 myeloid hyperplasia 1.57155815705253e-06 5.17781578234195e-05 2.00890042441323 0.636363636363636 16.3 16 3 increased adenoma incidence 9.14178400418145e-05 0.00179764329726493 2.00890042441323 0.636363636363636 16.3 16 3 premature suture closure 0.00601225738078967 0.0541586069603921 2.00890042441323 0.636363636363636 16.3 16 3 abnormal sphenoid bone morphology 0.00601225738078967 0.0541586069603921 2.00890042441323 0.636363636363636 16.3 16 3 delayed hepatic development 0.00601225738078967 0.0541586069603921 2.00890042441323 0.636363636363636 16.3 16 3 abnormal dorsal-ventral polarity of the somites 0.00601225738078967 0.0541586069603921 2.00890042441323 0.636363636363636 16.3 16 3 increased glycogen level 0.00601225738078967 0.0541586069603921 2.00890042441323 0.636363636363636 16.3 16 3 increased granulocyte number 6.54548795341059e-13 7.40086422004947e-11 2.00502223826571 0.635135135135135 16.3 16 3 small superior vagus ganglion 0.000328605612441392 0.00510879038092477 1.99379590994396 0.631578947368421 16.3 16 3 embryonic lethality between somite formation and embryo turning, complete penetrance 5.97671622547923e-12 6.19461733786649e-10 1.98430164370613 0.628571428571429 16.3 16 3 vertebral transformation 1.67769551434701e-08 8.51687263660856e-07 1.97302720254871 0.625 16.3 16 3 abnormal embryonic hematopoiesis 4.20258943896477e-06 0.000122987543875587 1.97302720254871 0.625 16.3 16 3 intraventricular hemorrhage 0.0011914381577521 0.014599519297578 1.97302720254871 0.625 16.3 16 3 small pancreas 0.0011914381577521 0.014599519297578 1.97302720254871 0.625 16.3 16 3 abnormal exoccipital bone morphology 0.023172876364623 0.142151738488286 1.97302720254871 0.625 16.3 16 3 schistocytosis 0.023172876364623 0.142151738488286 1.97302720254871 0.625 16.3 16 3 enlarged pituitary gland 0.023172876364623 0.142151738488286 1.97302720254871 0.625 16.3 16 3 abnormal umbilical artery morphology 0.023172876364623 0.142151738488286 1.97302720254871 0.625 16.3 16 3 binucleate 0.023172876364623 0.142151738488286 1.97302720254871 0.625 16.3 16 3 abnormal kidney epithelium morphology 0.023172876364623 0.142151738488286 1.97302720254871 0.625 16.3 16 3 abnormal NK cell morphology 0.023172876364623 0.142151738488286 1.97302720254871 0.625 16.3 16 3 abnormal choroid pigmentation 0.023172876364623 0.142151738488286 1.97302720254871 0.625 16.3 16 3 craniofacial phenotype 0.023172876364623 0.142151738488286 1.97302720254871 0.625 16.3 16 3 abnormal thymus epithelium morphology 0.023172876364623 0.142151738488286 1.97302720254871 0.625 16.3 16 3 enlarged inguinal lymph nodes 0.023172876364623 0.142151738488286 1.97302720254871 0.625 16.3 16 3 abnormal olfactory bulb mitral cell layer morphology 0.023172876364623 0.142151738488286 1.97302720254871 0.625 16.3 16 3 increased caudal vertebrae number 0.023172876364623 0.142151738488286 1.97302720254871 0.625 16.3 16 3 abnormal circulating serum amyloid protein level 0.023172876364623 0.142151738488286 1.97302720254871 0.625 16.3 16 3 delayed suture closure 0.023172876364623 0.142151738488286 1.97302720254871 0.625 16.3 16 3 increased aorta wall thickness 0.023172876364623 0.142151738488286 1.97302720254871 0.625 16.3 16 3 abnormal macrophage activation involved in immune response 0.023172876364623 0.142151738488286 1.97302720254871 0.625 16.3 16 3 increased circulating ferritin level 0.023172876364623 0.142151738488286 1.97302720254871 0.625 16.3 16 3 absent hypoglossal canal 0.023172876364623 0.142151738488286 1.97302720254871 0.625 16.3 16 3 abnormal umbilical vein topology 0.023172876364623 0.142151738488286 1.97302720254871 0.625 16.3 16 3 embryo cyst 0.023172876364623 0.142151738488286 1.97302720254871 0.625 16.3 16 3 increased brain apoptosis 0.023172876364623 0.142151738488286 1.97302720254871 0.625 16.3 16 3 blood in lymph vessels 1.47192237948618e-05 0.00036244402264201 1.9594201183932 0.620689655172414 16.3 16 3 liver degeneration 0.000245310420869884 0.00398071965267491 1.95423646728634 0.619047619047619 16.3 16 3 abnormal tumor vascularization 0.000245310420869884 0.00398071965267491 1.95423646728634 0.619047619047619 16.3 16 3 absent segment of posterior cerebral artery 0.000245310420869884 0.00398071965267491 1.95423646728634 0.619047619047619 16.3 16 3 absent common myeloid progenitor cells 0.0043699965334816 0.0421332030117655 1.94267293789411 0.615384615384615 16.3 16 3 abnormal mast cell morphology 0.0043699965334816 0.0421332030117655 1.94267293789411 0.615384615384615 16.3 16 3 abnormal coping response 0.0043699965334816 0.0421332030117655 1.94267293789411 0.615384615384615 16.3 16 3 extramedullary hematopoiesis 3.45918229697438e-16 7.17059663643647e-14 1.93580027419873 0.613207547169811 16.3 16 3 abnormal bile duct morphology 0.000876956706026067 0.0113912783615658 1.92918215360318 0.611111111111111 16.3 16 3 increased B cell proliferation 1.62930070475703e-09 1.08076946748883e-07 1.92620960791196 0.610169491525424 16.3 16 3 abnormal T cell subpopulation ratio 8.25032987267588e-06 0.00022067414578797 1.91323849944117 0.606060606060606 16.3 16 3 pale yolk sac 2.28775158291203e-12 2.52923647221941e-10 1.90171296631201 0.602409638554217 16.3 16 3 trabecula carnea hypoplasia 2.91306152252513e-07 1.20770675621354e-05 1.89410611444676 0.6 16.3 16 3 waved hair 0.000641657399941714 0.0088427854978117 1.89410611444676 0.6 16.3 16 3 abnormal thymocyte activation 0.000641657399941714 0.0088427854978117 1.89410611444676 0.6 16.3 16 3 increased skin tumor incidence 0.000641657399941714 0.0088427854978117 1.89410611444676 0.6 16.3 16 3 absent ductus venosus valve 0.000641657399941714 0.0088427854978117 1.89410611444676 0.6 16.3 16 3 decreased incidence of induced tumors 0.0162881915059172 0.110853286924676 1.89410611444676 0.6 16.3 16 3 abnormal airway responsiveness 0.0162881915059172 0.110853286924676 1.89410611444676 0.6 16.3 16 3 peritoneal inflammation 0.0162881915059172 0.110853286924676 1.89410611444676 0.6 16.3 16 3 absent CD4-positive, alpha beta T cells 0.0162881915059172 0.110853286924676 1.89410611444676 0.6 16.3 16 3 abnormal gas homeostasis 0.0162881915059172 0.110853286924676 1.89410611444676 0.6 16.3 16 3 abnormal gonadal fat pad morphology 0.0162881915059172 0.110853286924676 1.89410611444676 0.6 16.3 16 3 absent axillary lymph nodes 0.0162881915059172 0.110853286924676 1.89410611444676 0.6 16.3 16 3 aorta stenosis 0.0162881915059172 0.110853286924676 1.89410611444676 0.6 16.3 16 3 abnormal spleen marginal zone morphology 2.85093928201711e-05 0.000636027933992607 1.89410611444676 0.6 16.3 16 3 abnormal lymph node B cell domain morphology 0.00315580523993383 0.033333611610766 1.89410611444676 0.6 16.3 16 3 delayed intramembranous bone ossification 0.00315580523993383 0.033333611610766 1.89410611444676 0.6 16.3 16 3 liver hypoplasia 4.77838103865309e-08 2.28581208339415e-06 1.88196440858492 0.596153846153846 16.3 16 3 abnormal cell nucleus morphology 2.17045788401962e-07 9.25282820834925e-06 1.88067273774856 0.595744680851064 16.3 16 3 increased fibroblast apoptosis 2.1051768851804e-05 0.000496953504460023 1.87437584242127 0.59375 16.3 16 3 abnormal eye muscle morphology 9.84751102940899e-05 0.00191372528794179 1.87072208834248 0.592592592592593 16.3 16 3 decreased circulating fructosamine level 9.84751102940899e-05 0.00191372528794179 1.87072208834248 0.592592592592593 16.3 16 3 increased bone volume 0.000467599704288208 0.00682201914614027 1.86540753695514 0.590909090909091 16.3 16 3 impaired humoral immune response 0.000467599704288208 0.00682201914614027 1.86540753695514 0.590909090909091 16.3 16 3 abnormal erythropoiesis 2.04343991220582e-14 2.82392043422887e-12 1.86404093802697 0.59047619047619 16.3 16 3 decreased double-positive T cell number 9.09642635675988e-14 1.0774933601162e-11 1.86253767920598 0.59 16.3 16 3 impaired hematopoiesis 1.19630898757172e-07 5.26693558687551e-06 1.85696677886937 0.588235294117647 16.3 16 3 abnormal dorsal-ventral axis patterning 0.00227089823992035 0.0253312079452999 1.85696677886937 0.588235294117647 16.3 16 3 absence seizures 0.00227089823992035 0.0253312079452999 1.85696677886937 0.588235294117647 16.3 16 3 abnormal embryonic-extraembryonic boundary morphology 0.00227089823992035 0.0253312079452999 1.85696677886937 0.588235294117647 16.3 16 3 increased trabecular bone mass 0.00227089823992035 0.0253312079452999 1.85696677886937 0.588235294117647 16.3 16 3 abnormal osteoclast morphology 4.01152763354742e-07 1.58105159731809e-05 1.84149205571213 0.583333333333333 16.3 16 3 decreased metastatic potential 0.000339802572603952 0.00523380123437975 1.84149205571213 0.583333333333333 16.3 16 3 hemolytic anemia 0.000339802572603952 0.00523380123437975 1.84149205571213 0.583333333333333 16.3 16 3 increased body temperature 0.000339802572603952 0.00523380123437975 1.84149205571213 0.583333333333333 16.3 16 3 amyloidosis 0.0114485365108847 0.0880316370040981 1.84149205571213 0.583333333333333 16.3 16 3 abnormal embryonic growth/weight/body size 0.0114485365108847 0.0880316370040981 1.84149205571213 0.583333333333333 16.3 16 3 altered tumor susceptibility 0.0114485365108847 0.0880316370040981 1.84149205571213 0.583333333333333 16.3 16 3 increased growth rate 0.0114485365108847 0.0880316370040981 1.84149205571213 0.583333333333333 16.3 16 3 increased osteosarcoma incidence 0.0114485365108847 0.0880316370040981 1.84149205571213 0.583333333333333 16.3 16 3 pale placenta 0.0114485365108847 0.0880316370040981 1.84149205571213 0.583333333333333 16.3 16 3 abnormal fatty acid level 0.0114485365108847 0.0880316370040981 1.84149205571213 0.583333333333333 16.3 16 3 hemoperitoneum 0.0114485365108847 0.0880316370040981 1.84149205571213 0.583333333333333 16.3 16 3 abnormal pulmonary valve cusp morphology 0.0114485365108847 0.0880316370040981 1.84149205571213 0.583333333333333 16.3 16 3 decreased circulating total protein level 6.54325316406371e-08 2.98648481570798e-06 1.83670895946352 0.581818181818182 16.3 16 3 impaired macrophage phagocytosis 1.82495154675044e-06 5.89554152278146e-05 1.83537414190577 0.581395348837209 16.3 16 3 abnormal stationary movement 0.001630939459705 0.0191366127642272 1.82764625078196 0.578947368421053 16.3 16 3 oliguria 0.001630939459705 0.0191366127642272 1.82764625078196 0.578947368421053 16.3 16 3 distended pericardium 2.17604201080776e-07 9.25282820834925e-06 1.82125587927573 0.576923076923077 16.3 16 3 increased leukemia incidence 0.000246444553371633 0.00398071965267491 1.82125587927573 0.576923076923077 16.3 16 3 decreased bone resorption 0.000246444553371633 0.00398071965267491 1.82125587927573 0.576923076923077 16.3 16 3 increased cardiomyocyte apoptosis 3.84251503234778e-05 0.000831152708083921 1.81757657446911 0.575757575757576 16.3 16 3 decreased T cell proliferation 3.67242297451902e-18 1.07472378224895e-15 1.81305202396368 0.574324324324324 16.3 16 3 increased double-negative T cell number 2.61814828020231e-08 1.30252876940065e-06 1.81130366135619 0.573770491803279 16.3 16 3 spleen hyperplasia 7.11909097419152e-10 5.20845258773571e-08 1.80992362047135 0.573333333333333 16.3 16 3 increased B cell number 1.52199192200975e-14 2.16340280342814e-12 1.8077650949848 0.572649572649573 16.3 16 3 lymphoid hyperplasia 0.000178483899787164 0.00312661056845472 1.80391058518739 0.571428571428571 16.3 16 3 small superior cervical ganglion 0.000178483899787164 0.00312661056845472 1.80391058518739 0.571428571428571 16.3 16 3 increased bone resorption 0.000178483899787164 0.00312661056845472 1.80391058518739 0.571428571428571 16.3 16 3 subcutaneous edema 0.000178483899787164 0.00312661056845472 1.80391058518739 0.571428571428571 16.3 16 3 abnormal erythrocyte physiology 0.00117012003870415 0.0144092752290919 1.80391058518739 0.571428571428571 16.3 16 3 increased muscle cell glucose uptake 0.00117012003870415 0.0144092752290919 1.80391058518739 0.571428571428571 16.3 16 3 amyloid beta deposits 0.00805778414755315 0.0688968882733533 1.80391058518739 0.571428571428571 16.3 16 3 abnormal vascular endothelial cell migration 0.00805778414755315 0.0688968882733533 1.80391058518739 0.571428571428571 16.3 16 3 abnormal maternal decidual layer morphology 0.00805778414755315 0.0688968882733533 1.80391058518739 0.571428571428571 16.3 16 3 increased pulmonary respiratory rate 0.00805778414755315 0.0688968882733533 1.80391058518739 0.571428571428571 16.3 16 3 sternebra fusion 0.00805778414755315 0.0688968882733533 1.80391058518739 0.571428571428571 16.3 16 3 abnormal vitelline vein topology 0.00805778414755315 0.0688968882733533 1.80391058518739 0.571428571428571 16.3 16 3 abnormal liver development 2.79839575069879e-05 0.000627117966654345 1.80391058518739 0.571428571428571 16.3 16 3 abnormal hippocampus pyramidal cell morphology 2.79839575069879e-05 0.000627117966654345 1.80391058518739 0.571428571428571 16.3 16 3 abnormal dendritic cell physiology 2.96656107233375e-13 3.43224217089777e-11 1.79969584082947 0.570093457943925 16.3 16 3 abnormal inflammatory response 2.3316797594874e-09 1.4865193346985e-07 1.7976470067666 0.569444444444444 16.3 16 3 abnormal myelopoiesis 3.25979486320953e-06 0.000100107897805354 1.7936610932261 0.568181818181818 16.3 16 3 abnormal astrocyte morphology 3.25979486320953e-06 0.000100107897805354 1.7936610932261 0.568181818181818 16.3 16 3 decreased IgM level 5.77755966237374e-12 6.11560836602326e-10 1.78996282293079 0.56701030927835 16.3 16 3 abnormal brain vasculature morphology 0.000129133913723925 0.00242430649349633 1.78887799697749 0.566666666666667 16.3 16 3 abnormal cell cycle 8.72660873625788e-14 1.05889947470446e-11 1.78430286143535 0.565217391304348 16.3 16 3 failure to gastrulate 2.37774837995949e-06 7.63180528406351e-05 1.78430286143535 0.565217391304348 16.3 16 3 pancreas inflammation 0.000839101210138664 0.0109621719662582 1.78430286143535 0.565217391304348 16.3 16 3 small liver 9.22715560563123e-10 6.46550692084724e-08 1.78078352640294 0.564102564102564 16.3 16 3 overriding aortic valve 1.73297779583479e-06 5.63500949952816e-05 1.77572448229384 0.5625 16.3 16 3 decreased lymphocyte cell number 5.80961501779112e-15 9.63427823783694e-13 1.77572448229384 0.5625 16.3 16 3 abnormal osteoclast physiology 3.38012398926441e-08 1.64863890652848e-06 1.77572448229384 0.5625 16.3 16 3 decreased mast cell number 0.00568142005988178 0.052335488050003 1.77572448229384 0.5625 16.3 16 3 increased cochlear outer hair cell number 0.00568142005988178 0.052335488050003 1.77572448229384 0.5625 16.3 16 3 abnormal level of surface class II molecules 0.00568142005988178 0.052335488050003 1.77572448229384 0.5625 16.3 16 3 dystonia 0.00568142005988178 0.052335488050003 1.77572448229384 0.5625 16.3 16 3 abnormal Langerhans cell physiology 0.00568142005988178 0.052335488050003 1.77572448229384 0.5625 16.3 16 3 arrested B cell differentiation 1.07453242530373e-05 0.000275556639994126 1.77091222082421 0.560975609756098 16.3 16 3 abnormal cell differentiation 1.07453242530373e-05 0.000275556639994126 1.77091222082421 0.560975609756098 16.3 16 3 abnormal B cell differentiation 6.04528514286917e-11 5.01254893096235e-09 1.76921999701071 0.56043956043956 16.3 16 3 increased B cell derived lymphoma incidence 1.26218571466366e-06 4.27168294588553e-05 1.76783237348364 0.56 16.3 16 3 abnormal egg cylinder morphology 0.000601639116361495 0.00840773765140011 1.76783237348364 0.56 16.3 16 3 abnormal definitive hematopoiesis 4.42958149214487e-11 3.86616981112644e-09 1.76511680916185 0.559139784946237 16.3 16 3 enlarged spleen 3.35613410993913e-31 2.38525245670674e-28 1.76476322005746 0.559027777777778 16.3 16 3 increased neutrophil cell number 2.08162136503657e-16 4.50263751785084e-14 1.76347810655388 0.558620689655172 16.3 16 3 abnormal cytokine secretion 2.56709306573949e-17 6.81780042590981e-15 1.76291261734222 0.558441558441558 16.3 16 3 decreased circulating serum albumin level 1.73790763257422e-11 1.60112786519569e-09 1.75380195782107 0.555555555555556 16.3 16 3 increased mean corpuscular hemoglobin 1.73790763257422e-11 1.60112786519569e-09 1.75380195782107 0.555555555555556 16.3 16 3 abnormal lysosome morphology 4.8733124877623e-05 0.00101442383374968 1.75380195782107 0.555555555555556 16.3 16 3 abnormal Peyer's patch follicle morphology 0.00401332515728821 0.0395372131831858 1.75380195782107 0.555555555555556 16.3 16 3 darkened coat color 0.00401332515728821 0.0395372131831858 1.75380195782107 0.555555555555556 16.3 16 3 decreased lactate dehydrogenase level 0.00401332515728821 0.0395372131831858 1.75380195782107 0.555555555555556 16.3 16 3 increased effector memory CD4-positive, alpha-beta T cell number 0.00401332515728821 0.0395372131831858 1.75380195782107 0.555555555555556 16.3 16 3 abnormal germ cell morphology 0.0419256140110354 0.2235583383761 1.75380195782107 0.555555555555556 16.3 16 3 abnormal artery development 0.0419256140110354 0.2235583383761 1.75380195782107 0.555555555555556 16.3 16 3 abnormal thymus physiology 0.0419256140110354 0.2235583383761 1.75380195782107 0.555555555555556 16.3 16 3 decreased cellular sensitivity to ionizing radiation 0.0419256140110354 0.2235583383761 1.75380195782107 0.555555555555556 16.3 16 3 positive geotaxis 0.0419256140110354 0.2235583383761 1.75380195782107 0.555555555555556 16.3 16 3 abnormal liver vasculature morphology 0.0419256140110354 0.2235583383761 1.75380195782107 0.555555555555556 16.3 16 3 multiflagellated sperm 0.0419256140110354 0.2235583383761 1.75380195782107 0.555555555555556 16.3 16 3 eye opacity 0.0419256140110354 0.2235583383761 1.75380195782107 0.555555555555556 16.3 16 3 axonal spheroids 0.0419256140110354 0.2235583383761 1.75380195782107 0.555555555555556 16.3 16 3 abnormal incisor color 0.0419256140110354 0.2235583383761 1.75380195782107 0.555555555555556 16.3 16 3 abnormal telomere morphology 0.0419256140110354 0.2235583383761 1.75380195782107 0.555555555555556 16.3 16 3 decreased susceptibility to parasitic infection induced morbidity/mortality 0.0419256140110354 0.2235583383761 1.75380195782107 0.555555555555556 16.3 16 3 abnormal infrahyoid muscle connection 0.0419256140110354 0.2235583383761 1.75380195782107 0.555555555555556 16.3 16 3 increased cardiac muscle glycogen level 0.0419256140110354 0.2235583383761 1.75380195782107 0.555555555555556 16.3 16 3 decreased platelet dense granule number 0.0419256140110354 0.2235583383761 1.75380195782107 0.555555555555556 16.3 16 3 decreased tumor growth/size 6.68433085288924e-07 2.44518720537676e-05 1.75380195782107 0.555555555555556 16.3 16 3 thymus hypoplasia 4.93790548298304e-15 8.47106199235883e-13 1.73855150601393 0.550724637681159 16.3 16 3 abnormal sperm mitochondrial sheath morphology 0.00284006197719345 0.0307158876881248 1.73626393824286 0.55 16.3 16 3 decreased bone marrow cell number 1.63501420553328e-08 8.38576873456502e-07 1.72977727346736 0.547945205479452 16.3 16 3 decreased inflammatory response 1.44544175030278e-09 9.71766582129236e-08 1.72874764413792 0.547619047619048 16.3 16 3 abnormal cytotoxic T cell physiology 1.83480455023572e-05 0.000436753714709221 1.72874764413792 0.547619047619048 16.3 16 3 decreased leukocyte cell number 1.14129348103963e-14 1.7205863842946e-12 1.72819900953171 0.547445255474453 16.3 16 3 decreased susceptibility to viral infection induced morbidity/mortality 0.00201314444000327 0.0230769437534937 1.72191464949705 0.545454545454545 16.3 16 3 abnormal sebaceous gland morphology 0.0286193124560701 0.170312296015489 1.72191464949705 0.545454545454545 16.3 16 3 abnormal eye distance/ position 0.0286193124560701 0.170312296015489 1.72191464949705 0.545454545454545 16.3 16 3 vasculitis 0.0286193124560701 0.170312296015489 1.72191464949705 0.545454545454545 16.3 16 3 retinal detachment 0.0286193124560701 0.170312296015489 1.72191464949705 0.545454545454545 16.3 16 3 loss of cortex neurons 0.0286193124560701 0.170312296015489 1.72191464949705 0.545454545454545 16.3 16 3 increased number of Howell-Jolly bodies 0.0286193124560701 0.170312296015489 1.72191464949705 0.545454545454545 16.3 16 3 common atrioventricular valve 0.0286193124560701 0.170312296015489 1.72191464949705 0.545454545454545 16.3 16 3 reduced sympathetic cervical ganglion size 0.0286193124560701 0.170312296015489 1.72191464949705 0.545454545454545 16.3 16 3 abnormal skeleton physiology 0.000159285255804393 0.00286751971302147 1.72191464949705 0.545454545454545 16.3 16 3 increased leukocyte cell number 3.23851123816436e-15 5.96725681846952e-13 1.71993543725625 0.544827586206897 16.3 16 3 abnormal placenta morphology 6.29045369700526e-09 3.43901177391222e-07 1.718281918169 0.544303797468354 16.3 16 3 abnormal cell death 9.56395005072255e-06 0.000251749478848385 1.71567582830322 0.543478260869565 16.3 16 3 abnormal lymphocyte physiology 9.56395005072255e-06 0.000251749478848385 1.71567582830322 0.543478260869565 16.3 16 3 embryonic lethality between implantation and placentation, complete penetrance 9.56395005072255e-06 0.000251749478848385 1.71567582830322 0.543478260869565 16.3 16 3 blindness 0.00142918141813423 0.0172159262838204 1.70995690887555 0.541666666666667 16.3 16 3 decreased IgG level 1.01801470054208e-11 9.73965987537858e-10 1.70640190490699 0.540540540540541 16.3 16 3 abnormal angiogenesis 2.73206693861896e-08 1.34574584352765e-06 1.70640190490699 0.540540540540541 16.3 16 3 abnormal vitelline vasculature morphology 5.39072741970368e-12 5.83018889413604e-10 1.7019504216768 0.539130434782609 16.3 16 3 decreased B cell number 2.84404010616341e-20 1.28628177528754e-17 1.7010176270517 0.538834951456311 16.3 16 3 increased autoantibody level 5.89927512253565e-05 0.00119791402998428 1.69983882065735 0.538461538461538 16.3 16 3 heart inflammation 0.001016032773183 0.0129609308886805 1.69983882065735 0.538461538461538 16.3 16 3 abnormal Mullerian duct morphology 0.001016032773183 0.0129609308886805 1.69983882065735 0.538461538461538 16.3 16 3 decreased Peyer's patch number 0.001016032773183 0.0129609308886805 1.69983882065735 0.538461538461538 16.3 16 3 absent teeth 0.0197068331511883 0.130201188482286 1.69983882065735 0.538461538461538 16.3 16 3 increased pituitary adenoma incidence 0.0197068331511883 0.130201188482286 1.69983882065735 0.538461538461538 16.3 16 3 lymphoid hypoplasia 0.0197068331511883 0.130201188482286 1.69983882065735 0.538461538461538 16.3 16 3 axonal dystrophy 0.0197068331511883 0.130201188482286 1.69983882065735 0.538461538461538 16.3 16 3 increased cochlear inner hair cell number 0.0197068331511883 0.130201188482286 1.69983882065735 0.538461538461538 16.3 16 3 axon degeneration 2.59978329462318e-06 8.2381668093951e-05 1.69534189256037 0.537037037037037 16.3 16 3 increased inflammatory response 4.88918339329686e-10 3.74210575102337e-08 1.69472652345236 0.536842105263158 16.3 16 3 straub tail 0.000723239961947099 0.00991217303219509 1.69116617361318 0.535714285714286 16.3 16 3 increased erythrocyte cell number 9.79569267843328e-07 3.40794203323116e-05 1.68364987950823 0.533333333333333 16.3 16 3 abnormal cell migration 2.19194279408208e-05 0.000511967859181143 1.68364987950823 0.533333333333333 16.3 16 3 abnormal microglial cell physiology 0.000515421592629634 0.00747586712341816 1.68364987950823 0.533333333333333 16.3 16 3 decreased hepatocyte number 0.0136600457562609 0.0992031301142507 1.68364987950823 0.533333333333333 16.3 16 3 arthritis 0.0136600457562609 0.0992031301142507 1.68364987950823 0.533333333333333 16.3 16 3 immune system phenotype 0.0136600457562609 0.0992031301142507 1.68364987950823 0.533333333333333 16.3 16 3 decreased thymocyte apoptosis 0.0136600457562609 0.0992031301142507 1.68364987950823 0.533333333333333 16.3 16 3 abnormal branching involved in lung morphogenesis 0.0136600457562609 0.0992031301142507 1.68364987950823 0.533333333333333 16.3 16 3 heterochrony 0.0136600457562609 0.0992031301142507 1.68364987950823 0.533333333333333 16.3 16 3 decreased hemoglobin content 8.55142550145544e-14 1.05889947470446e-11 1.6791720872755 0.531914893617021 16.3 16 3 pallor 1.03318899480831e-16 2.33641602235061e-14 1.67763684422427 0.531428571428571 16.3 16 3 decreased susceptibility to parasitic infection 0.000367709036563631 0.00559435002111335 1.6770731221664 0.53125 16.3 16 3 increased fatty acid level 0.000367709036563631 0.00559435002111335 1.6770731221664 0.53125 16.3 16 3 anemia 9.09327228081202e-20 3.23135925693142e-17 1.67567049619303 0.530805687203792 16.3 16 3 increased sarcoma incidence 1.13478992161169e-05 0.000286577657868943 1.67505982910258 0.530612244897959 16.3 16 3 increased monocyte cell number 4.20381682504687e-10 3.26781073509503e-08 1.6731270677613 0.53 16.3 16 3 increased lung adenocarcinoma incidence 8.16887562954068e-06 0.000219676520307918 1.67127010098243 0.529411764705882 16.3 16 3 abnormal trophoblast layer morphology 8.16887562954068e-06 0.000219676520307918 1.67127010098243 0.529411764705882 16.3 16 3 abnormal spleen red pulp morphology 0.000262583896901229 0.00421404802285037 1.67127010098243 0.529411764705882 16.3 16 3 abnormal direction of heart looping 0.000262583896901229 0.00421404802285037 1.67127010098243 0.529411764705882 16.3 16 3 abnormal bone marrow cavity morphology 0.00951825710733838 0.0791861690786094 1.67127010098243 0.529411764705882 16.3 16 3 increased regulatory T cell number 0.00951825710733838 0.0791861690786094 1.67127010098243 0.529411764705882 16.3 16 3 increased brain size 0.00951825710733838 0.0791861690786094 1.67127010098243 0.529411764705882 16.3 16 3 abnormal circulating chemokine level 0.00951825710733838 0.0791861690786094 1.67127010098243 0.529411764705882 16.3 16 3 abnormal ductus venosus valve morphology 0.00951825710733838 0.0791861690786094 1.67127010098243 0.529411764705882 16.3 16 3 decreased erythrocyte cell number 6.62979645453132e-15 1.0639753987514e-12 1.6689045382068 0.528662420382166 16.3 16 3 atrioventricular septal defect 5.88216658662404e-06 0.000162576548713637 1.66776639007891 0.528301886792453 16.3 16 3 incomplete somite formation 0.0001342532339706 0.00250153497754208 1.66149659161996 0.526315789473684 16.3 16 3 abnormal triglyceride level 0.0066604203768251 0.0594893920551254 1.66149659161996 0.526315789473684 16.3 16 3 unresponsive to tactile stimuli 0.0066604203768251 0.0594893920551254 1.66149659161996 0.526315789473684 16.3 16 3 decreased cell proliferation 7.4838285593755e-17 1.77295462299491e-14 1.65520984775978 0.524324324324324 16.3 16 3 gliosis 1.14325547589623e-06 3.9225489604026e-05 1.65358470308844 0.523809523809524 16.3 16 3 skin edema 6.8848273696145e-05 0.00138672130217944 1.65358470308844 0.523809523809524 16.3 16 3 left pulmonary isomerism 0.00467699810953167 0.0447462799902309 1.65358470308844 0.523809523809524 16.3 16 3 complete atrioventricular septal defect 0.00467699810953167 0.0447462799902309 1.65358470308844 0.523809523809524 16.3 16 3 decreased T cell number 1.23911113164314e-14 1.81311114115431e-12 1.64704879517109 0.521739130434783 16.3 16 3 increased lymphocyte cell number 4.29051261048652e-07 1.65467443698996e-05 1.64704879517109 0.521739130434783 16.3 16 3 conjunctivitis 0.00329391887258287 0.0345500606400138 1.64704879517109 0.521739130434783 16.3 16 3 increased susceptibility to fungal infection 0.00329391887258287 0.0345500606400138 1.64704879517109 0.521739130434783 16.3 16 3 lethality throughout fetal growth and development, complete penetrance 6.28880968043768e-17 1.56434140800887e-14 1.64488162570376 0.521052631578947 16.3 16 3 abnormal cochlear outer hair cell morphology 0.00232568557838803 0.0258843081710972 1.64155863252052 0.52 16.3 16 3 decreased IgA level 1.31031326817339e-05 0.000325940425458131 1.63913029134816 0.519230769230769 16.3 16 3 abnormal leukocyte migration 1.31031326817339e-05 0.000325940425458131 1.63913029134816 0.519230769230769 16.3 16 3 increased brain weight 0.00164563045191393 0.0192635564665219 1.63688182729967 0.518518518518518 16.3 16 3 abnormal spleen morphology 2.85394212861251e-15 5.46090849609509e-13 1.632850098661 0.517241379310345 16.3 16 3 abnormal microglial cell morphology 0.00116663831701907 0.0144092752290919 1.632850098661 0.517241379310345 16.3 16 3 decreased trophoblast giant cell number 0.00116663831701907 0.0144092752290919 1.632850098661 0.517241379310345 16.3 16 3 abnormal CD8-positive, alpha-beta T cell physiology 0.00116663831701907 0.0144092752290919 1.632850098661 0.517241379310345 16.3 16 3 abnormal object recognition memory 0.000828445221406193 0.0109324004681586 1.62933859307248 0.516129032258065 16.3 16 3 inner cell mass degeneration 0.000828445221406193 0.0109324004681586 1.62933859307248 0.516129032258065 16.3 16 3 abnormal T cell proliferation 0.000828445221406193 0.0109324004681586 1.62933859307248 0.516129032258065 16.3 16 3 enlarged pericardium 0.000589159303620321 0.00825652826904534 1.62625272452499 0.515151515151515 16.3 16 3 abnormal T cell differentiation 2.36050306414435e-09 1.4865193346985e-07 1.62530557675299 0.514851485148515 16.3 16 3 decreased mean corpuscular hemoglobin 9.42307546677961e-07 3.30139439769215e-05 1.6248459315107 0.514705882352941 16.3 16 3 abnormal midbrain development 0.00041954052790272 0.00621546396146311 1.62351952666865 0.514285714285714 16.3 16 3 increased red blood cell distribution width 0.00041954052790272 0.00621546396146311 1.62351952666865 0.514285714285714 16.3 16 3 double outlet right ventricle 8.92780657290695e-10 6.34511967145887e-08 1.62267657779707 0.514018691588785 16.3 16 3 abnormal forebrain development 4.89482542743206e-07 1.87321203857496e-05 1.62226681098449 0.513888888888889 16.3 16 3 malocclusion 0.000299108417509194 0.004697259354336 1.62108180966164 0.513513513513513 16.3 16 3 impaired macrophage chemotaxis 0.000213474794755067 0.00366219691002226 1.61889411491176 0.512820512820513 16.3 16 3 embryonic lethality during organogenesis, complete penetrance 1.3920588472296e-44 6.92549276496724e-41 1.61788230608994 0.5125 16.3 16 3 abnormal myocardial trabeculae morphology 7.80321072373155e-05 0.00155907523496243 1.61349780119539 0.511111111111111 16.3 16 3 decreased osteoclast cell number 7.80321072373155e-05 0.00155907523496243 1.61349780119539 0.511111111111111 16.3 16 3 embryonic lethality between implantation and somite formation, complete penetrance 5.64469977324301e-20 2.16018318245261e-17 1.61063445106017 0.510204081632653 16.3 16 3 decreased circulating calcium level 1.47891731851915e-05 0.00036244402264201 1.60712033953058 0.509090909090909 16.3 16 3 abnormal T-helper 2 physiology 1.47891731851915e-05 0.00036244402264201 1.60712033953058 0.509090909090909 16.3 16 3 decreased birth body size 5.26890505405019e-10 3.91235860356712e-08 1.6061133718993 0.508771929824561 16.3 16 3 increased hepatocellular carcinoma incidence 1.06217990131188e-05 0.000275556639994126 1.6061133718993 0.508771929824561 16.3 16 3 decreased embryo size 3.59103075932312e-37 5.9425745672721e-34 1.60483886265886 0.50836820083682 16.3 16 3 increased tumor incidence 1.04283660142913e-10 8.23509855890461e-09 1.60388017755572 0.508064516129032 16.3 16 3 spleen hypoplasia 4.12842059065359e-09 2.42526509846929e-07 1.59345435024886 0.504761904761905 16.3 16 3 abnormal humoral immune response 4.12842059065359e-09 2.42526509846929e-07 1.59345435024886 0.504761904761905 16.3 16 3 prenatal lethality, complete penetrance 1.64021210481528e-21 8.16005522145604e-19 1.58977731428385 0.503597122302158 16.3 16 3 thrombocytopenia 6.32313306577555e-12 6.4199157147415e-10 1.58930742936337 0.503448275862069 16.3 16 3 lethality throughout fetal growth and development, incomplete penetrance 2.59967765233656e-14 3.49551251902011e-12 1.58723976070957 0.502793296089385 16.3 16 3 small heart 8.63580262728336e-05 0.00170488563772757 1.57842176203897 0.5 16.3 16 3 abnormal trophoblast giant cell morphology 0.000651400734527872 0.008952261475901 1.57842176203897 0.5 16.3 16 3 shortened head 0.00256802094188076 0.0282538586855262 1.57842176203897 0.5 16.3 16 3 ocular hypertelorism 0.00515865632703148 0.0488844099561554 1.57842176203897 0.5 16.3 16 3 abnormal nursing 0.00515865632703148 0.0488844099561554 1.57842176203897 0.5 16.3 16 3 abnormal megakaryocyte differentiation 0.0150231890573886 0.105565488079814 1.57842176203897 0.5 16.3 16 3 abnormal white adipose tissue morphology 0.0150231890573886 0.105565488079814 1.57842176203897 0.5 16.3 16 3 increased circulating glycerol level 0.0150231890573886 0.105565488079814 1.57842176203897 0.5 16.3 16 3 absent inner cell mass 0.0150231890573886 0.105565488079814 1.57842176203897 0.5 16.3 16 3 abnormal neutrophil morphology 0.0150231890573886 0.105565488079814 1.57842176203897 0.5 16.3 16 3 decreased tumor latency 0.0150231890573886 0.105565488079814 1.57842176203897 0.5 16.3 16 3 increased adipocyte glucose uptake 0.0150231890573886 0.105565488079814 1.57842176203897 0.5 16.3 16 3 abnormal blood flow velocity 0.0313558821548234 0.18267735089041 1.57842176203897 0.5 16.3 16 3 absent visceral yolk sac blood islands 0.0313558821548234 0.18267735089041 1.57842176203897 0.5 16.3 16 3 increased hemangioma incidence 0.0313558821548234 0.18267735089041 1.57842176203897 0.5 16.3 16 3 abnormal voluntary movement 0.0313558821548234 0.18267735089041 1.57842176203897 0.5 16.3 16 3 vascular smooth muscle hypoplasia 0.0313558821548234 0.18267735089041 1.57842176203897 0.5 16.3 16 3 decreased compact bone area 0.0313558821548234 0.18267735089041 1.57842176203897 0.5 16.3 16 3 mesocardia 0.0457900884012556 0.224401663679248 1.57842176203897 0.5 16.3 16 3 abnormal pilomotor reflex 0.0457900884012556 0.224401663679248 1.57842176203897 0.5 16.3 16 3 myocarditis 0.0457900884012556 0.224401663679248 1.57842176203897 0.5 16.3 16 3 increased litter size 0.0457900884012556 0.224401663679248 1.57842176203897 0.5 16.3 16 3 abnormal respiratory function 0.0457900884012556 0.224401663679248 1.57842176203897 0.5 16.3 16 3 small intestinal inflammation 0.0457900884012556 0.224401663679248 1.57842176203897 0.5 16.3 16 3 abnormal vascular endothelial cell development 0.0457900884012556 0.224401663679248 1.57842176203897 0.5 16.3 16 3 abnormal cochlear outer hair cell physiology 0.0457900884012556 0.224401663679248 1.57842176203897 0.5 16.3 16 3 hematuria 0.0457900884012556 0.224401663679248 1.57842176203897 0.5 16.3 16 3 decreased keratinocyte proliferation 0.0457900884012556 0.224401663679248 1.57842176203897 0.5 16.3 16 3 increased fibrosarcoma incidence 0.0457900884012556 0.224401663679248 1.57842176203897 0.5 16.3 16 3 persistent right dorsal aorta 0.0457900884012556 0.224401663679248 1.57842176203897 0.5 16.3 16 3 prenatal growth retardation 0.0457900884012556 0.224401663679248 1.57842176203897 0.5 16.3 16 3 abnormal vitelline vein connection 0.0457900884012556 0.224401663679248 1.57842176203897 0.5 16.3 16 3 abnormal locomotor behavior 6.18016797065525e-08 2.90059770320848e-06 1.57842176203897 0.5 16.3 16 3 increased embryonic tissue cell apoptosis 6.08811430194827e-07 2.24358286312538e-05 1.57842176203897 0.5 16.3 16 3 pericardial edema 3.14335188045026e-06 9.77385975327502e-05 1.57842176203897 0.5 16.3 16 3 abnormal vascular development 4.369140248999e-06 0.000126374841504477 1.57842176203897 0.5 16.3 16 3 decreased platelet aggregation 3.17866155829944e-05 0.000696644989098665 1.57842176203897 0.5 16.3 16 3 abnormal myelin sheath morphology 0.000120666083380976 0.00228256184342341 1.57842176203897 0.5 16.3 16 3 abnormal spleen white pulp morphology 0.000236161964094174 0.00395591168810948 1.57842176203897 0.5 16.3 16 3 decreased total retina thickness 0.000463963601047786 0.00682201914614027 1.57842176203897 0.5 16.3 16 3 enlarged liver sinusoidal spaces 0.000915734710339408 0.0118640108956733 1.57842176203897 0.5 16.3 16 3 abnormal spongiotrophoblast layer morphology 0.00128918140624876 0.0156813630711187 1.57842176203897 0.5 16.3 16 3 arrested T cell differentiation 0.0018178550414085 0.0211304411939422 1.57842176203897 0.5 16.3 16 3 abnormal leukocyte cell number 0.00363533838359305 0.0366109482963066 1.57842176203897 0.5 16.3 16 3 ventricular hypoplasia 0.00363533838359305 0.0366109482963066 1.57842176203897 0.5 16.3 16 3 increased thymocyte apoptosis 0.00363533838359305 0.0366109482963066 1.57842176203897 0.5 16.3 16 3 abnormal abdominal fat pad morphology 0.00734085177906009 0.0645242713795476 1.57842176203897 0.5 16.3 16 3 abnormal germ layer development 0.00734085177906009 0.0645242713795476 1.57842176203897 0.5 16.3 16 3 abnormal vascular branching morphogenesis 0.00734085177906009 0.0645242713795476 1.57842176203897 0.5 16.3 16 3 abnormal retinal layer morphology 0.00734085177906009 0.0645242713795476 1.57842176203897 0.5 16.3 16 3 abnormal mesenteric lymph node morphology 0.00734085177906009 0.0645242713795476 1.57842176203897 0.5 16.3 16 3 abnormal occipital bone morphology 0.00734085177906009 0.0645242713795476 1.57842176203897 0.5 16.3 16 3 abnormal sperm midpiece morphology 0.00734085177906009 0.0645242713795476 1.57842176203897 0.5 16.3 16 3 abnormal cerebral cortex pyramidal cell morphology 0.00734085177906009 0.0645242713795476 1.57842176203897 0.5 16.3 16 3 abnormal cell proliferation 0.0104807787764568 0.0859009463144522 1.57842176203897 0.5 16.3 16 3 abnormal physiological neovascularization 0.0104807787764568 0.0859009463144522 1.57842176203897 0.5 16.3 16 3 abnormal optic stalk morphology 0.0104807787764568 0.0859009463144522 1.57842176203897 0.5 16.3 16 3 abnormal bone marrow cell number 0.0216386714526401 0.140906270257702 1.57842176203897 0.5 16.3 16 3 disorganized yolk sac vascular plexus 0.0216386714526401 0.140906270257702 1.57842176203897 0.5 16.3 16 3 large intestinal inflammation 0.0216386714526401 0.140906270257702 1.57842176203897 0.5 16.3 16 3 blepharitis 0.0216386714526401 0.140906270257702 1.57842176203897 0.5 16.3 16 3 impaired somite development 0.0216386714526401 0.140906270257702 1.57842176203897 0.5 16.3 16 3 decreased liver cholesterol level 0.0216386714526401 0.140906270257702 1.57842176203897 0.5 16.3 16 3 kidney hemorrhage 0.0675630365161537 0.284951552035273 1.57842176203897 0.5 16.3 16 3 enlarged testis 0.0675630365161537 0.284951552035273 1.57842176203897 0.5 16.3 16 3 abnormal mammary gland physiology 0.0675630365161537 0.284951552035273 1.57842176203897 0.5 16.3 16 3 abnormal PNS synaptic transmission 0.0675630365161537 0.284951552035273 1.57842176203897 0.5 16.3 16 3 primary sex reversal 0.0675630365161537 0.284951552035273 1.57842176203897 0.5 16.3 16 3 abnormal glial cell physiology 0.0675630365161537 0.284951552035273 1.57842176203897 0.5 16.3 16 3 increased atrioventricular cushion size 0.0675630365161537 0.284951552035273 1.57842176203897 0.5 16.3 16 3 abnormal ear physiology 0.0675630365161537 0.284951552035273 1.57842176203897 0.5 16.3 16 3 abnormal plasma membrane morphology 0.0675630365161537 0.284951552035273 1.57842176203897 0.5 16.3 16 3 abnormal embryonic erythrocyte morphology 0.0675630365161537 0.284951552035273 1.57842176203897 0.5 16.3 16 3 abnormal placental transport 0.0675630365161537 0.284951552035273 1.57842176203897 0.5 16.3 16 3 abnormal developmental vascular remodeling 0.0675630365161537 0.284951552035273 1.57842176203897 0.5 16.3 16 3 abnormal hippocampus neuron morphology 0.0675630365161537 0.284951552035273 1.57842176203897 0.5 16.3 16 3 acanthocytosis 0.0675630365161537 0.284951552035273 1.57842176203897 0.5 16.3 16 3 increased T-helper 17 cell number 0.0675630365161537 0.284951552035273 1.57842176203897 0.5 16.3 16 3 increased kidney iron level 0.0675630365161537 0.284951552035273 1.57842176203897 0.5 16.3 16 3 thin ventricle myocardium compact layer 0.0675630365161537 0.284951552035273 1.57842176203897 0.5 16.3 16 3 thick aortic valve cusps 0.0675630365161537 0.284951552035273 1.57842176203897 0.5 16.3 16 3 fusion of atlas and odontoid process 0.0675630365161537 0.284951552035273 1.57842176203897 0.5 16.3 16 3 abnormal adaptive thermogenesis 0.0675630365161537 0.284951552035273 1.57842176203897 0.5 16.3 16 3 abnormal circadian temperature homeostasis 0.0675630365161537 0.284951552035273 1.57842176203897 0.5 16.3 16 3 decreased macrophage apoptosis 0.0675630365161537 0.284951552035273 1.57842176203897 0.5 16.3 16 3 lethality during fetal growth through weaning, complete penetrance 0.0675630365161537 0.284951552035273 1.57842176203897 0.5 16.3 16 3 thrombocytosis 1.63736224978903e-05 0.000397359863058558 1.57842176203897 0.5 16.3 16 3 embryonic growth arrest 2.60378307723189e-17 6.81780042590981e-15 1.57152909058901 0.497816593886463 16.3 16 3 abnormal hepatocyte morphology 5.0188954966483e-09 2.83738694270742e-07 1.56420174616474 0.495495495495495 16.3 16 3 increased T cell proliferation 9.61199426570262e-09 5.08719909275218e-07 1.56367015678627 0.495327102803738 16.3 16 3 increased grip strength 1.30012759770033e-07 5.67380245487644e-06 1.56107646795063 0.494505494505495 16.3 16 3 abnormal placenta labyrinth morphology 9.23919652180431e-07 3.25992926921819e-05 1.55844173973468 0.493670886075949 16.3 16 3 abnormal response to infection 9.23919652180431e-07 3.25992926921819e-05 1.55844173973468 0.493670886075949 16.3 16 3 abnormal myocardium layer morphology 9.23919652180431e-07 3.25992926921819e-05 1.55844173973468 0.493670886075949 16.3 16 3 decreased hematocrit 3.06863354934713e-11 2.72615212642893e-09 1.55679954612062 0.493150684931507 16.3 16 3 abnormal CD4-positive, alpha-beta T cell physiology 3.43201558057376e-06 0.000104111448252161 1.55619046961588 0.492957746478873 16.3 16 3 perimembraneous ventricular septal defect 4.7682529476284e-06 0.000137121724939025 1.55554608432826 0.492753623188406 16.3 16 3 increased osteoclast cell number 1.78319426344173e-05 0.000426509204837627 1.55254599544816 0.491803278688525 16.3 16 3 incomplete embryo turning 3.45732321815386e-05 0.0007510996947736 1.55073015217863 0.491228070175439 16.3 16 3 absent vitelline blood vessels 3.45732321815386e-05 0.0007510996947736 1.55073015217863 0.491228070175439 16.3 16 3 abnormal T-helper 1 physiology 0.0001827520156393 0.00319014483440533 1.54483832029346 0.48936170212766 16.3 16 3 abnormal vasculogenesis 0.000357501223586677 0.00547251873028836 1.54171427920085 0.488372093023256 16.3 16 3 increased bone trabecula number 0.000500686532220084 0.00728337864852315 1.53992367028192 0.48780487804878 16.3 16 3 pale liver 3.70086031132679e-06 0.000110250179933238 1.53576171441629 0.486486486486487 16.3 16 3 abnormal vocalization 0.00098515135065083 0.0126644133578498 1.53576171441629 0.486486486486487 16.3 16 3 skin inflammation 0.00098515135065083 0.0126644133578498 1.53576171441629 0.486486486486487 16.3 16 3 hydrops fetalis 5.13788084348153e-06 0.000144412187549834 1.53457671309344 0.486111111111111 16.3 16 3 decreased bone volume 0.00138436254930739 0.0167571865761661 1.53332399740928 0.485714285714286 16.3 16 3 small spleen 4.02229321885392e-07 1.58105159731809e-05 1.52638587977394 0.483516483516484 16.3 16 3 increased susceptibility to induced arthritis 0.00387597805841835 0.0385659816812626 1.52399342541693 0.482758620689655 16.3 16 3 increased double-positive T cell number 0.00387597805841835 0.0385659816812626 1.52399342541693 0.482758620689655 16.3 16 3 polychromatophilia 0.00387597805841835 0.0385659816812626 1.52399342541693 0.482758620689655 16.3 16 3 abnormal atrioventricular cushion morphology 0.00548292432015224 0.0514670726278442 1.51996169677826 0.481481481481481 16.3 16 3 abnormal fetal cardiomyocyte proliferation 0.00548292432015224 0.0514670726278442 1.51996169677826 0.481481481481481 16.3 16 3 abnormal bone trabecula morphology 0.00548292432015224 0.0514670726278442 1.51996169677826 0.481481481481481 16.3 16 3 abnormal interventricular septum morphology 0.000194482925700696 0.0033830508928705 1.51528489155741 0.48 16.3 16 3 decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 0.00777370624885621 0.0682084454815866 1.51528489155741 0.48 16.3 16 3 abnormal allantois morphology 0.000379094294837851 0.00573250491434136 1.50979472890684 0.478260869565217 16.3 16 3 atrial septal defect 0.000379094294837851 0.00573250491434136 1.50979472890684 0.478260869565217 16.3 16 3 fragile skeleton 0.0110505402766642 0.0872641871054039 1.50979472890684 0.478260869565217 16.3 16 3 abnormal postnatal growth 0.0110505402766642 0.0872641871054039 1.50979472890684 0.478260869565217 16.3 16 3 abnormal Wolffian duct morphology 0.0110505402766642 0.0872641871054039 1.50979472890684 0.478260869565217 16.3 16 3 abnormal B cell morphology 0.0110505402766642 0.0872641871054039 1.50979472890684 0.478260869565217 16.3 16 3 abnormal chondrocyte physiology 0.0110505402766642 0.0872641871054039 1.50979472890684 0.478260869565217 16.3 16 3 decreased effector memory CD8-positive, alpha-beta T cell number 0.0110505402766642 0.0872641871054039 1.50979472890684 0.478260869565217 16.3 16 3 abnormal vertebral artery topology 0.0110505402766642 0.0872641871054039 1.50979472890684 0.478260869565217 16.3 16 3 ventricular septal defect 1.42532728255976e-09 9.71370305580108e-08 1.50878550783136 0.477941176470588 16.3 16 3 increased T cell number 1.13388537165787e-06 3.91741647499853e-05 1.50667531830992 0.477272727272727 16.3 16 3 decreased macrophage cell number 0.000529851170625922 0.00764060746047526 1.50667531830992 0.477272727272727 16.3 16 3 increased bone mineral content 6.47511834866815e-08 2.98275127635408e-06 1.50601709405553 0.477064220183486 16.3 16 3 embryonic lethality, complete penetrance 3.14698356066575e-20 1.30468693452601e-17 1.50420130300892 0.476489028213166 16.3 16 3 abnormal eye pigmentation 0.0157569430191159 0.109027526453549 1.50325882098949 0.476190476190476 16.3 16 3 decreased cochlear outer hair cell number 0.0157569430191159 0.109027526453549 1.50325882098949 0.476190476190476 16.3 16 3 vascular ring 0.0157569430191159 0.109027526453549 1.50325882098949 0.476190476190476 16.3 16 3 abnormal NK cell physiology 5.4454927325691e-05 0.00111486939689429 1.50079446226656 0.475409836065574 16.3 16 3 increased rib number 5.7747960211794e-06 0.000160500615672444 1.49747705629338 0.474358974358974 16.3 16 3 abnormal cell morphology 4.94036628868448e-08 2.34079259868622e-06 1.49534693245797 0.473684210526316 16.3 16 3 decreased hair follicle number 0.00145422032529357 0.0173912166306142 1.49534693245797 0.473684210526316 16.3 16 3 abnormal compact bone morphology 0.00145422032529357 0.0173912166306142 1.49534693245797 0.473684210526316 16.3 16 3 enlarged adrenal glands 0.0225496808698957 0.142151738488286 1.49534693245797 0.473684210526316 16.3 16 3 altered susceptibility to infection 0.0225496808698957 0.142151738488286 1.49534693245797 0.473684210526316 16.3 16 3 increased malignant tumor incidence 0.0225496808698957 0.142151738488286 1.49534693245797 0.473684210526316 16.3 16 3 decreased tumor incidence 0.0225496808698957 0.142151738488286 1.49534693245797 0.473684210526316 16.3 16 3 increased susceptibility to ischemic brain injury 0.0225496808698957 0.142151738488286 1.49534693245797 0.473684210526316 16.3 16 3 osteoarthritis 0.0225496808698957 0.142151738488286 1.49534693245797 0.473684210526316 16.3 16 3 abnormal cochlear inner hair cell morphology 0.0225496808698957 0.142151738488286 1.49534693245797 0.473684210526316 16.3 16 3 decreased liver regeneration 0.0225496808698957 0.142151738488286 1.49534693245797 0.473684210526316 16.3 16 3 embryonic lethality between implantation and somite formation, incomplete penetrance 0.0225496808698957 0.142151738488286 1.49534693245797 0.473684210526316 16.3 16 3 abnormal T cell activation 1.10881880621367e-05 0.000281447630658826 1.49310166679362 0.472972972972973 16.3 16 3 abnormal platelet physiology 0.00014651483583909 0.00271981831455028 1.49232602956411 0.472727272727273 16.3 16 3 hemorrhage 7.61174770689447e-15 1.18338890130625e-12 1.49110481350064 0.472340425531915 16.3 16 3 anophthalmia 1.64932641371518e-06 5.39828875541645e-05 1.48974638214914 0.471910112359551 16.3 16 3 abnormal placenta development 0.000203957585266943 0.00351103455606589 1.48907713399902 0.471698113207547 16.3 16 3 lung inflammation 4.1436690124601e-09 2.42526509846929e-07 1.4855734230955 0.470588235294118 16.3 16 3 abnormal extraembryonic tissue morphology 3.42308830867203e-07 1.38454181590596e-05 1.4855734230955 0.470588235294118 16.3 16 3 abnormal gastrulation 0.000284059128543882 0.00452946847598016 1.4855734230955 0.470588235294118 16.3 16 3 abnormal brown adipose tissue morphology 0.00286561776284094 0.0309250506944331 1.4855734230955 0.470588235294118 16.3 16 3 abnormal adipose tissue morphology 0.0324123730929083 0.18267735089041 1.4855734230955 0.470588235294118 16.3 16 3 abnormal interatrial septum morphology 0.0324123730929083 0.18267735089041 1.4855734230955 0.470588235294118 16.3 16 3 abnormal involuntary movement 0.0324123730929083 0.18267735089041 1.4855734230955 0.470588235294118 16.3 16 3 abnormal ectoplacental cone morphology 0.0324123730929083 0.18267735089041 1.4855734230955 0.470588235294118 16.3 16 3 coloboma 0.0324123730929083 0.18267735089041 1.4855734230955 0.470588235294118 16.3 16 3 abnormal neural tube closure 4.36436224020836e-06 0.000126374841504477 1.48333611372337 0.469879518072289 16.3 16 3 abnormal embryonic tissue morphology 1.20166379943393e-09 8.30316305858859e-08 1.48178369497536 0.469387755102041 16.3 16 3 increased T cell derived lymphoma incidence 0.00039582530950009 0.00593141841796069 1.48178369497536 0.469387755102041 16.3 16 3 increased spleen weight 9.84947568639576e-08 4.37510192319812e-06 1.48064342279761 0.469026548672566 16.3 16 3 scoliosis 0.00403034910772999 0.0395482974575083 1.47977040191153 0.46875 16.3 16 3 neonatal lethality 0.00403034910772999 0.0395482974575083 1.47977040191153 0.46875 16.3 16 3 hepatic necrosis 0.000551875500532575 0.00788959946882058 1.47767143680244 0.468085106382979 16.3 16 3 increased cellular sensitivity to gamma-irradiation 0.000551875500532575 0.00788959946882058 1.47767143680244 0.468085106382979 16.3 16 3 decreased bone trabecula number 0.000551875500532575 0.00788959946882058 1.47767143680244 0.468085106382979 16.3 16 3 abnormal eye morphology 4.32451548520328e-09 2.49766669523268e-07 1.476221791835 0.467625899280576 16.3 16 3 preweaning lethality, complete penetrance 3.57206519762354e-42 8.88551217908855e-39 1.47603764774455 0.467567567567568 16.3 16 3 preweaning lethality, incomplete penetrance 9.58495570236997e-24 5.29835051325451e-21 1.47422277041292 0.466992665036675 16.3 16 3 abnormal eating behavior 0.000109539221737738 0.0020879602610929 1.4731936445697 0.466666666666667 16.3 16 3 muscular ventricular septal defect 0.000109539221737738 0.0020879602610929 1.4731936445697 0.466666666666667 16.3 16 3 increased metastatic potential 0.00567683569830196 0.052335488050003 1.4731936445697 0.466666666666667 16.3 16 3 salivary gland inflammation 0.00567683569830196 0.052335488050003 1.4731936445697 0.466666666666667 16.3 16 3 disorganized myocardium 0.00567683569830196 0.052335488050003 1.4731936445697 0.466666666666667 16.3 16 3 macrocytosis 0.0468397390035655 0.225365281956227 1.4731936445697 0.466666666666667 16.3 16 3 abnormal seizure response to electrical stimulation 0.0468397390035655 0.225365281956227 1.4731936445697 0.466666666666667 16.3 16 3 absent egg cylinders 0.0468397390035655 0.225365281956227 1.4731936445697 0.466666666666667 16.3 16 3 abnormal glial cell morphology 0.0468397390035655 0.225365281956227 1.4731936445697 0.466666666666667 16.3 16 3 abnormal cerebral aqueduct morphology 0.0468397390035655 0.225365281956227 1.4731936445697 0.466666666666667 16.3 16 3 abnormal secondary palate development 0.0468397390035655 0.225365281956227 1.4731936445697 0.466666666666667 16.3 16 3 decreased trabecular bone mass 0.0468397390035655 0.225365281956227 1.4731936445697 0.466666666666667 16.3 16 3 astrocytosis 2.21475974169468e-05 0.000514879893221075 1.47031068244726 0.465753424657534 16.3 16 3 dermatitis 0.000152102433327325 0.00280262816964238 1.4695650887949 0.46551724137931 16.3 16 3 rib bifurcation 0.0080091739146542 0.0688968882733533 1.46567735046475 0.464285714285714 16.3 16 3 abnormal spleen germinal center morphology 0.0080091739146542 0.0688968882733533 1.46567735046475 0.464285714285714 16.3 16 3 microcephaly 4.24530087004518e-05 0.000906453726543981 1.46404337348542 0.463768115942029 16.3 16 3 hemopericardium 0.00150143304768537 0.0178699268235281 1.46292748676782 0.463414634146341 16.3 16 3 abnormal neural tube morphology 5.17110058736105e-10 3.89791294274564e-08 1.46150163151756 0.462962962962963 16.3 16 3 abnormal axon morphology 3.69292060318337e-07 1.48163548393849e-05 1.46150163151756 0.462962962962963 16.3 16 3 abnormal apoptosis 0.000293552174329904 0.00465102569201042 1.46150163151756 0.462962962962963 16.3 16 3 decreased white adipose tissue amount 5.87893692875908e-05 0.00119791402998428 1.46062909323009 0.462686567164179 16.3 16 3 kinked neural tube 0.000408022157436454 0.00609582652626533 1.45700470342058 0.461538461538462 16.3 16 3 abnormal response to injury 0.00209904234666588 0.0238964203081528 1.45700470342058 0.461538461538462 16.3 16 3 abnormal nasal bone morphology 0.011320878704796 0.0880316370040981 1.45700470342058 0.461538461538462 16.3 16 3 increased susceptibility to otitis media 0.011320878704796 0.0880316370040981 1.45700470342058 0.461538461538462 16.3 16 3 decreased circulating glycerol level 0.011320878704796 0.0880316370040981 1.45700470342058 0.461538461538462 16.3 16 3 increased foot pad pigmentation 0.0681471643298848 0.286103073874411 1.45700470342058 0.461538461538462 16.3 16 3 abnormal grip strength 0.0681471643298848 0.286103073874411 1.45700470342058 0.461538461538462 16.3 16 3 abnormal exocrine pancreas morphology 0.0681471643298848 0.286103073874411 1.45700470342058 0.461538461538462 16.3 16 3 empty decidua capsularis 0.0681471643298848 0.286103073874411 1.45700470342058 0.461538461538462 16.3 16 3 increased prostaglandin level 0.0681471643298848 0.286103073874411 1.45700470342058 0.461538461538462 16.3 16 3 decreased neutrophil cell number 1.45852610744592e-07 6.30971076916821e-06 1.45700470342058 0.461538461538462 16.3 16 3 short stride length 0.000567339191995872 0.00804134609737738 1.45214802107585 0.46 16.3 16 3 abnormal long bone metaphysis morphology 0.0029369367563137 0.0314220652960444 1.45044161917094 0.459459459459459 16.3 16 3 increased erythroid progenitor cell number 0.0029369367563137 0.0314220652960444 1.45044161917094 0.459459459459459 16.3 16 3 increased susceptibility to bacterial infection induced morbidity/mortality 4.35999930700069e-05 0.000923021129886315 1.44688661520239 0.458333333333333 16.3 16 3 increased hemangiosarcoma incidence 0.016035980541738 0.110344402759539 1.44688661520239 0.458333333333333 16.3 16 3 abnormal cellular extravasation 0.016035980541738 0.110344402759539 1.44688661520239 0.458333333333333 16.3 16 3 abnormal inner cell mass apoptosis 0.016035980541738 0.110344402759539 1.44688661520239 0.458333333333333 16.3 16 3 increased hemoglobin content 0.00021656013659543 0.00370235972358166 1.44465720593397 0.457627118644068 16.3 16 3 abnormal embryonic epiblast morphology 0.00411299057423761 0.0399821165996755 1.44312846814991 0.457142857142857 16.3 16 3 holoprosencephaly 0.00411299057423761 0.0399821165996755 1.44312846814991 0.457142857142857 16.3 16 3 abnormal immune system morphology 0.00109819523912849 0.0137967709966269 1.44116769577471 0.456521739130435 16.3 16 3 abnormal visceral yolk sac morphology 2.33572860551832e-05 0.000535495383062379 1.43856160590893 0.455696202531646 16.3 16 3 abnormal nervous system morphology 2.33572860551832e-05 0.000535495383062379 1.43856160590893 0.455696202531646 16.3 16 3 decreased sensitivity to induced morbidity/mortality 0.00152889232045791 0.018110093557805 1.43492887458088 0.454545454545455 16.3 16 3 abnormal facial nerve morphology 0.0227703523858292 0.142151738488286 1.43492887458088 0.454545454545455 16.3 16 3 increased activated T cell number 0.0227703523858292 0.142151738488286 1.43492887458088 0.454545454545455 16.3 16 3 intestinal inflammation 0.0227703523858292 0.142151738488286 1.43492887458088 0.454545454545455 16.3 16 3 increased myocardial infarction size 0.0227703523858292 0.142151738488286 1.43492887458088 0.454545454545455 16.3 16 3 abnormal basement membrane morphology 0.0227703523858292 0.142151738488286 1.43492887458088 0.454545454545455 16.3 16 3 abnormal food preference 0.100016139899557 0.376080650194594 1.43492887458088 0.454545454545455 16.3 16 3 impaired myelopoiesis 0.100016139899557 0.376080650194594 1.43492887458088 0.454545454545455 16.3 16 3 abnormal larynx morphology 0.100016139899557 0.376080650194594 1.43492887458088 0.454545454545455 16.3 16 3 rectal hemorrhage 0.100016139899557 0.376080650194594 1.43492887458088 0.454545454545455 16.3 16 3 abnormal lymph circulation 0.100016139899557 0.376080650194594 1.43492887458088 0.454545454545455 16.3 16 3 pathological neovascularization 0.100016139899557 0.376080650194594 1.43492887458088 0.454545454545455 16.3 16 3 abnormal hair medulla 0.100016139899557 0.376080650194594 1.43492887458088 0.454545454545455 16.3 16 3 abnormal coronal suture morphology 0.100016139899557 0.376080650194594 1.43492887458088 0.454545454545455 16.3 16 3 pharyngeal arch hypoplasia 0.100016139899557 0.376080650194594 1.43492887458088 0.454545454545455 16.3 16 3 abnormal spinal cord ventral horn morphology 0.100016139899557 0.376080650194594 1.43492887458088 0.454545454545455 16.3 16 3 aberrant origin of the right subclavian artery 0.100016139899557 0.376080650194594 1.43492887458088 0.454545454545455 16.3 16 3 aorta dilation 0.100016139899557 0.376080650194594 1.43492887458088 0.454545454545455 16.3 16 3 abnormal dendritic cell chemotaxis 0.100016139899557 0.376080650194594 1.43492887458088 0.454545454545455 16.3 16 3 abnormal pulmonary alveolar sac morphology 0.100016139899557 0.376080650194594 1.43492887458088 0.454545454545455 16.3 16 3 abnormal phrenic nerve innervation pattern to diaphragm 0.100016139899557 0.376080650194594 1.43492887458088 0.454545454545455 16.3 16 3 thin hypoglossal nerve 0.100016139899557 0.376080650194594 1.43492887458088 0.454545454545455 16.3 16 3 decreased brown adipose tissue amount 0.00576561858239306 0.052727853763613 1.43492887458088 0.454545454545455 16.3 16 3 increased sacral vertebrae number 0.000159140304530713 0.00286751971302147 1.43044472184781 0.453125 16.3 16 3 abnormal testis morphology 5.45690734201998e-07 2.04121158094356e-05 1.42744228914828 0.452173913043478 16.3 16 3 increased eosinophil cell number 0.000219991746113478 0.00373535473349677 1.42567126893842 0.451612903225806 16.3 16 3 pericardial effusion 0.000219991746113478 0.00373535473349677 1.42567126893842 0.451612903225806 16.3 16 3 abnormal capillary morphology 0.00809093718706536 0.0688968882733533 1.42567126893842 0.451612903225806 16.3 16 3 abnormal CD8-positive, alpha beta T cell morphology 0.00809093718706536 0.0688968882733533 1.42567126893842 0.451612903225806 16.3 16 3 decreased double-negative T cell number 0.00809093718706536 0.0688968882733533 1.42567126893842 0.451612903225806 16.3 16 3 small cranium 0.00809093718706536 0.0688968882733533 1.42567126893842 0.451612903225806 16.3 16 3 preaxial polydactyly 0.00809093718706536 0.0688968882733533 1.42567126893842 0.451612903225806 16.3 16 3 abnormal embryo size 7.49051457155173e-07 2.7200956199613e-05 1.42477008608827 0.451327433628319 16.3 16 3 small lung 0.000800033529831426 0.0107077659227094 1.42367453046652 0.450980392156863 16.3 16 3 increased circulating alkaline phosphatase level 3.79787074928882e-09 2.30419597289169e-07 1.42252825467709 0.450617283950617 16.3 16 3 decreased myocardial infarction size 0.0324242371281639 0.18267735089041 1.42057958583507 0.45 16.3 16 3 absent placental labyrinth 0.0324242371281639 0.18267735089041 1.42057958583507 0.45 16.3 16 3 spleen atrophy 0.0324242371281639 0.18267735089041 1.42057958583507 0.45 16.3 16 3 dilated vasculature 0.0324242371281639 0.18267735089041 1.42057958583507 0.45 16.3 16 3 abnormal neuron proliferation 0.0324242371281639 0.18267735089041 1.42057958583507 0.45 16.3 16 3 decreased muscle cell glucose uptake 0.0324242371281639 0.18267735089041 1.42057958583507 0.45 16.3 16 3 decreased rib number 1.26954310741268e-05 0.000318988735322126 1.41880607823727 0.449438202247191 16.3 16 3 abnormal respiratory system physiology 0.00110967624567708 0.0138709530709635 1.41735831693295 0.448979591836735 16.3 16 3 enlarged epididymis 0.0113673955478458 0.0880316370040981 1.41513675217287 0.448275862068966 16.3 16 3 decreased bone strength 0.0113673955478458 0.0880316370040981 1.41513675217287 0.448275862068966 16.3 16 3 decreased compact bone thickness 0.000160804212486676 0.00286751971302147 1.41351202570654 0.447761194029851 16.3 16 3 rib fusion 0.000160804212486676 0.00286751971302147 1.41351202570654 0.447761194029851 16.3 16 3 internal hemorrhage 0.000160804212486676 0.00286751971302147 1.41351202570654 0.447761194029851 16.3 16 3 increased bone marrow cell number 0.00413723100999665 0.0401222695413905 1.41227210287697 0.447368421052632 16.3 16 3 perinatal lethality, incomplete penetrance 8.0374684321728e-12 7.84047165687445e-10 1.41080175191093 0.446902654867257 16.3 16 3 neuron degeneration 0.0015394534895329 0.0181918791221524 1.41050455331142 0.446808510638298 16.3 16 3 abnormal craniofacial morphology 3.64109687346477e-06 0.000109123234611369 1.40985244764645 0.446601941747573 16.3 16 3 decreased monocyte cell number 0.000221744171476784 0.00375230358196259 1.40843787997323 0.446153846153846 16.3 16 3 abnormal behavior 4.26540479840654e-14 5.58431286107172e-12 1.4080884783657 0.446043165467626 16.3 16 3 increased neuron apoptosis 4.52878982836244e-05 0.000950663687599289 1.40304156625686 0.444444444444444 16.3 16 3 impaired limb coordination 0.000803583989360415 0.0107077659227094 1.40304156625686 0.444444444444444 16.3 16 3 abnormal heart valve morphology 0.0159912422125111 0.110344402759539 1.40304156625686 0.444444444444444 16.3 16 3 right pulmonary isomerism 0.0463237203213241 0.224401663679248 1.40304156625686 0.444444444444444 16.3 16 3 abnormal mammary gland morphology 0.0463237203213241 0.224401663679248 1.40304156625686 0.444444444444444 16.3 16 3 abnormal iron level 0.0463237203213241 0.224401663679248 1.40304156625686 0.444444444444444 16.3 16 3 eye inflammation 0.0463237203213241 0.224401663679248 1.40304156625686 0.444444444444444 16.3 16 3 abnormal thymus cortex morphology 0.0463237203213241 0.224401663679248 1.40304156625686 0.444444444444444 16.3 16 3 abnormal pregnancy 0.0463237203213241 0.224401663679248 1.40304156625686 0.444444444444444 16.3 16 3 increased gastrointestinal tumor incidence 0.0463237203213241 0.224401663679248 1.40304156625686 0.444444444444444 16.3 16 3 primary atelectasis 0.0463237203213241 0.224401663679248 1.40304156625686 0.444444444444444 16.3 16 3 increased effector memory CD8-positive, alpha-beta T cell number 0.0463237203213241 0.224401663679248 1.40304156625686 0.444444444444444 16.3 16 3 abnormal immune system physiology 5.62600409430837e-07 2.08875898277494e-05 1.40021285342166 0.443548387096774 16.3 16 3 abnormal nervous system physiology 1.4337854910857e-06 4.78730390479956e-05 1.39999147589543 0.443478260869565 16.3 16 3 domed cranium 0.000161388044149952 0.00286751971302147 1.39803070352023 0.442857142857143 16.3 16 3 edema 5.3774743396354e-09 2.97254831552068e-07 1.39488434784839 0.441860465116279 16.3 16 3 abnormal left-right axis patterning 0.00296445205313055 0.0315806187672902 1.39488434784839 0.441860465116279 16.3 16 3 abnormal homeostasis 0.00296445205313055 0.0315806187672902 1.39488434784839 0.441860465116279 16.3 16 3 abnormal embryo development 2.21892797991262e-07 9.35522601700447e-06 1.39272508415203 0.441176470588235 16.3 16 3 abnormal bone remodeling 0.00805509291361844 0.0688968882733533 1.39272508415203 0.441176470588235 16.3 16 3 decreased total body fat amount 7.94337898430938e-16 1.58073241787757e-13 1.38938921568699 0.440119760479042 16.3 16 3 embryonic lethality before implantation, complete penetrance 7.70467153460303e-07 2.77758991917754e-05 1.38901115059429 0.44 16.3 16 3 spontaneous skin ulceration 0.0225277674861452 0.142151738488286 1.38901115059429 0.44 16.3 16 3 abnormal primitive streak morphology 0.0225277674861452 0.142151738488286 1.38901115059429 0.44 16.3 16 3 increased pre-B cell number 0.0225277674861452 0.142151738488286 1.38901115059429 0.44 16.3 16 3 thick ventricular wall 0.00411474245206711 0.0399821165996755 1.38593130325373 0.439024390243902 16.3 16 3 decreased brain weight 0.00080086761866106 0.0107077659227094 1.38458049301664 0.43859649122807 16.3 16 3 increased macrophage cell number 0.00080086761866106 0.0107077659227094 1.38458049301664 0.43859649122807 16.3 16 3 decreased percent body fat/body weight 0.000161011555048503 0.00286751971302147 1.38382181877389 0.438356164383562 16.3 16 3 thymus atrophy 0.00212300595849843 0.0239927106375019 1.3811190417841 0.4375 16.3 16 3 decreased eosinophil cell number 0.000419778068553086 0.00621546396146311 1.3811190417841 0.4375 16.3 16 3 failure of primitive streak formation 0.0112491723598818 0.0880316370040981 1.3811190417841 0.4375 16.3 16 3 abnormal lymphatic vessel morphology 0.0112491723598818 0.0880316370040981 1.3811190417841 0.4375 16.3 16 3 abnormal heart atrium morphology 0.0112491723598818 0.0880316370040981 1.3811190417841 0.4375 16.3 16 3 abnormal epicardium morphology 0.0664405693209519 0.284951552035273 1.3811190417841 0.4375 16.3 16 3 abnormal pulmonary elastic fiber morphology 0.0664405693209519 0.284951552035273 1.3811190417841 0.4375 16.3 16 3 abnormal amnion morphology 0.0664405693209519 0.284951552035273 1.3811190417841 0.4375 16.3 16 3 sepsis 0.0664405693209519 0.284951552035273 1.3811190417841 0.4375 16.3 16 3 decreased midbrain size 0.0664405693209519 0.284951552035273 1.3811190417841 0.4375 16.3 16 3 abnormal heart development 4.6918384802207e-08 2.2662035377765e-06 1.37862153899606 0.436708860759494 16.3 16 3 abnormal embryo turning 0.00110358453100287 0.013829554261308 1.37753171959764 0.436363636363636 16.3 16 3 acanthosis 0.0057121949771159 0.052335488050003 1.376059997675 0.435897435897436 16.3 16 3 increased hepatocyte apoptosis 0.0057121949771159 0.052335488050003 1.376059997675 0.435897435897436 16.3 16 3 failure of heart looping 0.0057121949771159 0.052335488050003 1.376059997675 0.435897435897436 16.3 16 3 decreased trabecular bone volume 0.0057121949771159 0.052335488050003 1.376059997675 0.435897435897436 16.3 16 3 ataxia 8.39294337132425e-10 6.05143380758524e-08 1.37525856494484 0.435643564356436 16.3 16 3 embryonic lethality during organogenesis, incomplete penetrance 7.0813855753103e-11 5.77539233396209e-09 1.37254066264258 0.434782608695652 16.3 16 3 delayed wound healing 0.00293444963136535 0.0314220652960444 1.37254066264258 0.434782608695652 16.3 16 3 abnormal cranial nerve morphology 0.0317855924698021 0.18267735089041 1.37254066264258 0.434782608695652 16.3 16 3 abnormal circulating insulin level 0.0317855924698021 0.18267735089041 1.37254066264258 0.434782608695652 16.3 16 3 abnormal motor coordination/ balance 1.74513570789453e-05 0.000419422712404603 1.37115425793284 0.434343434343434 16.3 16 3 prenatal lethality, incomplete penetrance 7.97907059946797e-14 1.01784298031675e-11 1.37073468808647 0.434210526315789 16.3 16 3 abnormal glucose homeostasis 7.26359180921962e-09 3.92786622292039e-07 1.37027823297888 0.434065934065934 16.3 16 3 liver inflammation 2.6519751608795e-06 8.29784680841227e-05 1.36796552710044 0.433333333333333 16.3 16 3 absent mesoderm 0.00079285725795988 0.0107077659227094 1.36796552710044 0.433333333333333 16.3 16 3 intracranial hemorrhage 0.00079285725795988 0.0107077659227094 1.36796552710044 0.433333333333333 16.3 16 3 gastrointestinal hemorrhage 0.0157190001386735 0.109027526453549 1.36796552710044 0.433333333333333 16.3 16 3 liver hemorrhage 0.0157190001386735 0.109027526453549 1.36796552710044 0.433333333333333 16.3 16 3 abnormal fat pad morphology 0.0157190001386735 0.109027526453549 1.36796552710044 0.433333333333333 16.3 16 3 osteoporosis 0.00405547744996177 0.0397165360503146 1.36318243085183 0.431818181818182 16.3 16 3 abnormal neuromuscular synapse morphology 0.000299302756849148 0.004697259354336 1.35919651731133 0.430555555555556 16.3 16 3 abnormal bone structure 5.20753203964494e-09 2.91095189856557e-07 1.35760628237548 0.430051813471503 16.3 16 3 abnormal liver physiology 2.35328295181411e-05 0.000537045077306201 1.35744271535351 0.43 16.3 16 3 abnormal bone mineralization 3.56873375053127e-06 0.000107602729750867 1.35666002687647 0.429752066115702 16.3 16 3 abnormal pancreas morphology 0.00560368788345123 0.052335488050003 1.35293293889054 0.428571428571429 16.3 16 3 abnormal somite shape 0.0219777934359038 0.142151738488286 1.35293293889054 0.428571428571429 16.3 16 3 abnormal mitotic spindle morphology 0.0219777934359038 0.142151738488286 1.35293293889054 0.428571428571429 16.3 16 3 trunk curl 0.0449247077099499 0.224401663679248 1.35293293889054 0.428571428571429 16.3 16 3 abnormal hematopoietic system physiology 0.0449247077099499 0.224401663679248 1.35293293889054 0.428571428571429 16.3 16 3 increased incidence of induced tumors 0.0449247077099499 0.224401663679248 1.35293293889054 0.428571428571429 16.3 16 3 increased acute inflammation 0.0449247077099499 0.224401663679248 1.35293293889054 0.428571428571429 16.3 16 3 abnormal clavicle morphology 0.0449247077099499 0.224401663679248 1.35293293889054 0.428571428571429 16.3 16 3 embryonic lethality at implantation, complete penetrance 0.0449247077099499 0.224401663679248 1.35293293889054 0.428571428571429 16.3 16 3 midline facial cleft 0.0957406259611808 0.370092940292832 1.35293293889054 0.428571428571429 16.3 16 3 translucent skin 0.0957406259611808 0.370092940292832 1.35293293889054 0.428571428571429 16.3 16 3 increased aggression towards males 0.0957406259611808 0.370092940292832 1.35293293889054 0.428571428571429 16.3 16 3 abnormal adrenal gland secretion 0.0957406259611808 0.370092940292832 1.35293293889054 0.428571428571429 16.3 16 3 abnormal antigen presentation 0.0957406259611808 0.370092940292832 1.35293293889054 0.428571428571429 16.3 16 3 absent otoliths 0.0957406259611808 0.370092940292832 1.35293293889054 0.428571428571429 16.3 16 3 decreased coping response 0.0957406259611808 0.370092940292832 1.35293293889054 0.428571428571429 16.3 16 3 absent olfactory bulb 0.0957406259611808 0.370092940292832 1.35293293889054 0.428571428571429 16.3 16 3 abnormal hair cuticle 0.0957406259611808 0.370092940292832 1.35293293889054 0.428571428571429 16.3 16 3 abnormal positive T cell selection 0.0957406259611808 0.370092940292832 1.35293293889054 0.428571428571429 16.3 16 3 lysosomal protein accumulation 0.0957406259611808 0.370092940292832 1.35293293889054 0.428571428571429 16.3 16 3 increased stomach tumor incidence 0.0957406259611808 0.370092940292832 1.35293293889054 0.428571428571429 16.3 16 3 pulmonary alveolar hemorrhage 0.0957406259611808 0.370092940292832 1.35293293889054 0.428571428571429 16.3 16 3 testis degeneration 0.0957406259611808 0.370092940292832 1.35293293889054 0.428571428571429 16.3 16 3 abnormal lung morphology 4.84917759425054e-06 0.000138647462824118 1.35293293889054 0.428571428571429 16.3 16 3 increased thermal nociceptive threshold 6.03356364594177e-05 0.00122020240400652 1.35293293889054 0.428571428571429 16.3 16 3 abnormal long bone hypertrophic chondrocyte zone 0.00288300324311444 0.0310453271309402 1.35293293889054 0.428571428571429 16.3 16 3 thick pulmonary interalveolar septum 0.011011669668154 0.0872641871054039 1.35293293889054 0.428571428571429 16.3 16 3 retinal degeneration 4.35973395902622e-05 0.000923021129886315 1.34823525507495 0.427083333333333 16.3 16 3 decreased circulating alanine transaminase level 0.000559541931777149 0.00795348888740376 1.34630091468029 0.426470588235294 16.3 16 3 decreased susceptibility to injury 0.000559541931777149 0.00795348888740376 1.34630091468029 0.426470588235294 16.3 16 3 short snout 1.6768075346826e-05 0.000404957159468248 1.34458150099616 0.425925925925926 16.3 16 3 abnormal cell adhesion 0.00205217312003499 0.0234164249361791 1.34458150099616 0.425925925925926 16.3 16 3 decreased bone mineral density 2.5332433422881e-11 2.29143375052423e-09 1.34106510609326 0.424812030075188 16.3 16 3 abnormal ovarian folliculogenesis 0.0152896856696103 0.10728658139113 1.33926694960882 0.424242424242424 16.3 16 3 abnormal Schwann cell morphology 0.0307461525924678 0.180806275588094 1.3355876448022 0.423076923076923 16.3 16 3 thick skin 0.0307461525924678 0.180806275588094 1.3355876448022 0.423076923076923 16.3 16 3 pulmonary edema 0.0307461525924678 0.180806275588094 1.3355876448022 0.423076923076923 16.3 16 3 abnormal lipid homeostasis 3.39300933519834e-06 0.000103559640752219 1.3355876448022 0.423076923076923 16.3 16 3 premature death 7.51565180417869e-33 6.23172795429816e-30 1.33460051424433 0.422764227642276 16.3 16 3 thin ventricular wall 0.000109476386970204 0.0020879602610929 1.33288948794402 0.422222222222222 16.3 16 3 decreased circulating LDL cholesterol level 0.0010436258384748 0.0132788709626909 1.33179336172038 0.421875 16.3 16 3 impaired balance 4.18688683190659e-05 0.00089783456847997 1.33082619152305 0.42156862745098 16.3 16 3 impaired natural killer cell mediated cytotoxicity 0.00200039656743398 0.0229837711847206 1.32919727329597 0.421052631578947 16.3 16 3 decreased neuron apoptosis 0.0106896225372898 0.08674452780219 1.32919727329597 0.421052631578947 16.3 16 3 short vibrissae 0.0636139308314538 0.275438908517391 1.32919727329597 0.421052631578947 16.3 16 3 abnormal digestive system development 0.0636139308314538 0.275438908517391 1.32919727329597 0.421052631578947 16.3 16 3 abnormal optic vesicle formation 0.0636139308314538 0.275438908517391 1.32919727329597 0.421052631578947 16.3 16 3 absent amnion 0.0636139308314538 0.275438908517391 1.32919727329597 0.421052631578947 16.3 16 3 decreased eye pigmentation 0.0636139308314538 0.275438908517391 1.32919727329597 0.421052631578947 16.3 16 3 decreased fertilization frequency 0.0636139308314538 0.275438908517391 1.32919727329597 0.421052631578947 16.3 16 3 decreased spleen weight 0.00074547986396282 0.0101609926663425 1.32678930722116 0.420289855072464 16.3 16 3 decreased grip strength 3.35475717604126e-09 2.06048357417349e-07 1.32616257632498 0.420091324200913 16.3 16 3 prenatal lethality 0.00142381747966127 0.0171929416536767 1.32383760687139 0.419354838709677 16.3 16 3 decreased thymus weight 0.0212281567148349 0.139511333759978 1.32383760687139 0.419354838709677 16.3 16 3 hypoglycemia 0.000106820203095046 0.00206782299765703 1.32383760687139 0.419354838709677 16.3 16 3 increased sensitivity to xenobiotic induced morbidity/mortality 2.94365547864868e-05 0.000653780625280232 1.32013456461441 0.418181818181818 16.3 16 3 enlarged heart 1.72497047493776e-09 1.12917475168623e-07 1.31988716308431 0.418103448275862 16.3 16 3 abnormal somite development 0.000381492769333082 0.00575129250736994 1.31868147208319 0.417721518987342 16.3 16 3 oligodactyly 0.00528547592700993 0.0499909557735254 1.3153514683658 0.416666666666667 16.3 16 3 abnormal uterus morphology 0.0147548289721568 0.104715084360172 1.3153514683658 0.416666666666667 16.3 16 3 curly vibrissae 0.0430353152755624 0.224401663679248 1.3153514683658 0.416666666666667 16.3 16 3 abnormal sensory capabilities/reflexes/nociception 0.0430353152755624 0.224401663679248 1.3153514683658 0.416666666666667 16.3 16 3 small lymph nodes 0.0430353152755624 0.224401663679248 1.3153514683658 0.416666666666667 16.3 16 3 abnormal tumor morphology 0.0430353152755624 0.224401663679248 1.3153514683658 0.416666666666667 16.3 16 3 abnormal supraoccipital bone morphology 0.138749033826914 0.473646598823551 1.3153514683658 0.416666666666667 16.3 16 3 abnormal superior cervical ganglion morphology 0.138749033826914 0.473646598823551 1.3153514683658 0.416666666666667 16.3 16 3 impaired embryo implantation 0.138749033826914 0.473646598823551 1.3153514683658 0.416666666666667 16.3 16 3 abnormal thymus involution 0.138749033826914 0.473646598823551 1.3153514683658 0.416666666666667 16.3 16 3 increased papilloma incidence 0.138749033826914 0.473646598823551 1.3153514683658 0.416666666666667 16.3 16 3 small thyroid gland 0.138749033826914 0.473646598823551 1.3153514683658 0.416666666666667 16.3 16 3 loss of dopaminergic neurons 0.138749033826914 0.473646598823551 1.3153514683658 0.416666666666667 16.3 16 3 dilated bile duct 0.138749033826914 0.473646598823551 1.3153514683658 0.416666666666667 16.3 16 3 delayed somite formation 0.138749033826914 0.473646598823551 1.3153514683658 0.416666666666667 16.3 16 3 abnormal rostral-caudal body axis extension 0.138749033826914 0.473646598823551 1.3153514683658 0.416666666666667 16.3 16 3 stria vascularis degeneration 0.138749033826914 0.473646598823551 1.3153514683658 0.416666666666667 16.3 16 3 abnormal palatine bone morphology 0.138749033826914 0.473646598823551 1.3153514683658 0.416666666666667 16.3 16 3 hydrometra 0.138749033826914 0.473646598823551 1.3153514683658 0.416666666666667 16.3 16 3 decreased mammary gland epithelial cell proliferation 0.138749033826914 0.473646598823551 1.3153514683658 0.416666666666667 16.3 16 3 abnormal colon goblet cell morphology 0.138749033826914 0.473646598823551 1.3153514683658 0.416666666666667 16.3 16 3 epidermal hyperplasia 0.00194098527902967 0.0223527818591959 1.3153514683658 0.416666666666667 16.3 16 3 abnormal heart morphology 3.03603647509745e-09 1.88803518295123e-07 1.31193497104537 0.415584415584416 16.3 16 3 liver fibrosis 0.0103094794426846 0.0849166560055563 1.30893511973963 0.414634146341463 16.3 16 3 abnormal retina morphology 1.93273812202533e-08 9.71249712835962e-07 1.30783517426086 0.414285714285714 16.3 16 3 abnormal enzyme/coenzyme activity 1.15921586292122e-06 3.95006775207745e-05 1.30697343353545 0.414012738853503 16.3 16 3 lordosis 0.0294674860627683 0.1745246942408 1.3062800789288 0.413793103448276 16.3 16 3 increased mortality induced by gamma-irradiation 0.0294674860627683 0.1745246942408 1.3062800789288 0.413793103448276 16.3 16 3 abnormal outer ear morphology 0.0294674860627683 0.1745246942408 1.3062800789288 0.413793103448276 16.3 16 3 abnormal sleep pattern 0.00723402834011832 0.0644969372618076 1.30391362951045 0.41304347826087 16.3 16 3 decreased susceptibility to hepatic steatosis 0.0018759205309363 0.0217545562736786 1.30282431152423 0.412698412698413 16.3 16 3 increased insulin sensitivity 4.01642445516999e-06 0.00011823498026314 1.30247390154264 0.412587412587413 16.3 16 3 cleft palate 1.03839538293518e-05 0.000271895633163289 1.30129427710083 0.412213740458015 16.3 16 3 limb grasping 2.28512899507107e-07 9.55337542057024e-06 1.30089705662552 0.412087912087912 16.3 16 3 kinked tail 9.76660449777524e-05 0.0019129471408044 1.29987674520856 0.411764705882353 16.3 16 3 abnormal vagus nerve morphology 0.0902603066805824 0.368326074586212 1.29987674520856 0.411764705882353 16.3 16 3 enhanced behavioral response to cocaine 0.0902603066805824 0.368326074586212 1.29987674520856 0.411764705882353 16.3 16 3 abnormal electroretinogram waveform feature 0.0902603066805824 0.368326074586212 1.29987674520856 0.411764705882353 16.3 16 3 abnormal cell cytoskeleton morphology 0.0902603066805824 0.368326074586212 1.29987674520856 0.411764705882353 16.3 16 3 weight loss 4.23974377432891e-07 1.64786916228799e-05 1.29881562133492 0.411428571428571 16.3 16 3 abnormal seminal vesicle morphology 0.00359726531066209 0.0364488694919428 1.29656073310344 0.410714285714286 16.3 16 3 abnormal leukocyte adhesion 0.0141521808400195 0.10072546449084 1.29511529192941 0.41025641025641 16.3 16 3 muscular atrophy 0.00989133322604238 0.0817431607966127 1.29143598712279 0.409090909090909 16.3 16 3 decreased blood urea nitrogen level 0.00989133322604238 0.0817431607966127 1.29143598712279 0.409090909090909 16.3 16 3 lethality, incomplete penetrance 0.00989133322604238 0.0817431607966127 1.29143598712279 0.409090909090909 16.3 16 3 abnormal basisphenoid bone morphology 0.0602623383189565 0.26602052629708 1.29143598712279 0.409090909090909 16.3 16 3 abnormal long bone epiphysis morphology 0.0602623383189565 0.26602052629708 1.29143598712279 0.409090909090909 16.3 16 3 intracerebral hemorrhage 0.0602623383189565 0.26602052629708 1.29143598712279 0.409090909090909 16.3 16 3 testis hypoplasia 0.0602623383189565 0.26602052629708 1.29143598712279 0.409090909090909 16.3 16 3 abnormal lysosome physiology 0.0602623383189565 0.26602052629708 1.29143598712279 0.409090909090909 16.3 16 3 cleft upper lip 0.0602623383189565 0.26602052629708 1.29143598712279 0.409090909090909 16.3 16 3 rough coat 0.0602623383189565 0.26602052629708 1.29143598712279 0.409090909090909 16.3 16 3 increased mammary gland tumor incidence 0.0602623383189565 0.26602052629708 1.29143598712279 0.409090909090909 16.3 16 3 embryonic lethality before implantation, incomplete penetrance 0.0602623383189565 0.26602052629708 1.29143598712279 0.409090909090909 16.3 16 3 abnormal liver morphology 5.30904126421864e-07 2.01621986942655e-05 1.28742780590888 0.407821229050279 16.3 16 3 increased cell proliferation 0.00488943812779825 0.0465104296095532 1.28612143573545 0.407407407407407 16.3 16 3 abnormal small intestine morphology 0.00488943812779825 0.0465104296095532 1.28612143573545 0.407407407407407 16.3 16 3 neurodegeneration 0.00488943812779825 0.0465104296095532 1.28612143573545 0.407407407407407 16.3 16 3 rectal prolapse 0.0408901534786881 0.221599687970015 1.28612143573545 0.407407407407407 16.3 16 3 decreased susceptibility to pharmacologically induced seizures 0.0408901534786881 0.221599687970015 1.28612143573545 0.407407407407407 16.3 16 3 impaired glucose tolerance 4.367778944427e-09 2.49766669523268e-07 1.28564998359625 0.407258064516129 16.3 16 3 increased oxygen consumption 0.000465392286639956 0.00682201914614027 1.28476189933404 0.406976744186047 16.3 16 3 decreased caudal vertebrae number 0.00244538532051523 0.0269751484912711 1.28246768165666 0.40625 16.3 16 3 abnormal vertebral body morphology 0.0280558828524343 0.168572484530025 1.28246768165666 0.40625 16.3 16 3 abnormal depression-related behavior 0.0280558828524343 0.168572484530025 1.28246768165666 0.40625 16.3 16 3 bradykinesia 0.0280558828524343 0.168572484530025 1.28246768165666 0.40625 16.3 16 3 increased brown adipose tissue amount 0.0194076299702723 0.129427559118103 1.27980142868024 0.405405405405405 16.3 16 3 increased circulating phosphate level 0.0194076299702723 0.129427559118103 1.27980142868024 0.405405405405405 16.3 16 3 abnormal breathing pattern 0.0194076299702723 0.129427559118103 1.27980142868024 0.405405405405405 16.3 16 3 decreased circulating chloride level 0.0194076299702723 0.129427559118103 1.27980142868024 0.405405405405405 16.3 16 3 decreased width of hypertrophic chondrocyte zone 0.0194076299702723 0.129427559118103 1.27980142868024 0.405405405405405 16.3 16 3 abnormal calcium ion homeostasis 0.0194076299702723 0.129427559118103 1.27980142868024 0.405405405405405 16.3 16 3 increased trabecular bone volume 0.0194076299702723 0.129427559118103 1.27980142868024 0.405405405405405 16.3 16 3 abnormal respiratory electron transport chain 0.0194076299702723 0.129427559118103 1.27980142868024 0.405405405405405 16.3 16 3 disheveled coat 0.0135094177029633 0.0992031301142507 1.27776999784107 0.404761904761905 16.3 16 3 spina bifida 0.0135094177029633 0.0992031301142507 1.27776999784107 0.404761904761905 16.3 16 3 abnormal neuron morphology 0.000228626711118936 0.00385565385700578 1.27549233296078 0.404040404040404 16.3 16 3 seizures 8.4157014489272e-05 0.00166805237882123 1.27381405357531 0.403508771929825 16.3 16 3 maternal effect 0.00234146778479454 0.0259438802435475 1.27216082313588 0.402985074626866 16.3 16 3 sparse hair 0.000841718530876509 0.0109621719662582 1.27043702798258 0.402439024390244 16.3 16 3 abnormal developmental patterning 0.000841718530876509 0.0109621719662582 1.27043702798258 0.402439024390244 16.3 16 3 postnatal growth retardation 3.72826631828446e-19 1.15925780834157e-16 1.26892729889407 0.401960784313726 16.3 16 3 hydroencephaly 0.000107827617800085 0.00207923410292799 1.26273740963117 0.4 16.3 16 3 decreased insulin secretion 0.000574352104682231 0.00807175627342966 1.26273740963117 0.4 16.3 16 3 increased susceptibility to parasitic infection 0.000574352104682231 0.00807175627342966 1.26273740963117 0.4 16.3 16 3 abnormal ectoderm development 0.0128468117799382 0.0969846564570448 1.26273740963117 0.4 16.3 16 3 lethality at weaning, complete penetrance 0.0128468117799382 0.0969846564570448 1.26273740963117 0.4 16.3 16 3 ruffled hair 0.0567070138018406 0.257817130646727 1.26273740963117 0.4 16.3 16 3 increased cellular sensitivity to ionizing radiation 0.0567070138018406 0.257817130646727 1.26273740963117 0.4 16.3 16 3 increased liver glycogen level 0.0567070138018406 0.257817130646727 1.26273740963117 0.4 16.3 16 3 kyphosis 1.06736479110302e-05 0.000275556639994126 1.26273740963117 0.4 16.3 16 3 abnormal posture 0.00112992787408571 0.0140886996831489 1.26273740963117 0.4 16.3 16 3 abnormal rostral-caudal axis patterning 0.00632641610072916 0.0568121301464397 1.26273740963117 0.4 16.3 16 3 decreased circulating phosphate level 0.0184263480941858 0.124384100093045 1.26273740963117 0.4 16.3 16 3 perinatal lethality 0.0184263480941858 0.124384100093045 1.26273740963117 0.4 16.3 16 3 abnormal pancreatic beta cell morphology 0.0184263480941858 0.124384100093045 1.26273740963117 0.4 16.3 16 3 ovary cysts 0.0265820545525717 0.161078832398348 1.26273740963117 0.4 16.3 16 3 increased carcinoma incidence 0.0265820545525717 0.161078832398348 1.26273740963117 0.4 16.3 16 3 abnormal optic cup morphology 0.0386331433454982 0.211208668289949 1.26273740963117 0.4 16.3 16 3 abnormal cellular respiration 0.0386331433454982 0.211208668289949 1.26273740963117 0.4 16.3 16 3 abnormal vascular regression 0.0844070599669805 0.348196619681367 1.26273740963117 0.4 16.3 16 3 abnormal circulating enzyme level 0.0844070599669805 0.348196619681367 1.26273740963117 0.4 16.3 16 3 increased urine glucose level 0.0844070599669805 0.348196619681367 1.26273740963117 0.4 16.3 16 3 brain inflammation 0.0844070599669805 0.348196619681367 1.26273740963117 0.4 16.3 16 3 increased mammary adenocarcinoma incidence 0.0844070599669805 0.348196619681367 1.26273740963117 0.4 16.3 16 3 abnormal hyoid bone morphology 0.0844070599669805 0.348196619681367 1.26273740963117 0.4 16.3 16 3 abnormal heart right ventricle morphology 0.0844070599669805 0.348196619681367 1.26273740963117 0.4 16.3 16 3 abnormal response to tactile stimuli 0.0844070599669805 0.348196619681367 1.26273740963117 0.4 16.3 16 3 abnormal induced retinal neovascularization 0.0844070599669805 0.348196619681367 1.26273740963117 0.4 16.3 16 3 decreased salivation 0.128341217266258 0.458690772916403 1.26273740963117 0.4 16.3 16 3 abnormal prostate gland morphology 0.128341217266258 0.458690772916403 1.26273740963117 0.4 16.3 16 3 audiogenic seizures 0.128341217266258 0.458690772916403 1.26273740963117 0.4 16.3 16 3 placental labyrinth hypoplasia 0.128341217266258 0.458690772916403 1.26273740963117 0.4 16.3 16 3 increased airway responsiveness 0.128341217266258 0.458690772916403 1.26273740963117 0.4 16.3 16 3 abnormal cricoid cartilage morphology 0.128341217266258 0.458690772916403 1.26273740963117 0.4 16.3 16 3 joint inflammation 0.128341217266258 0.458690772916403 1.26273740963117 0.4 16.3 16 3 abnormal ear development 0.128341217266258 0.458690772916403 1.26273740963117 0.4 16.3 16 3 abnormal olfactory nerve morphology 0.128341217266258 0.458690772916403 1.26273740963117 0.4 16.3 16 3 liver vascular congestion 0.128341217266258 0.458690772916403 1.26273740963117 0.4 16.3 16 3 bicuspid aortic valve 0.128341217266258 0.458690772916403 1.26273740963117 0.4 16.3 16 3 abnormal coronary vessel morphology 0.128341217266258 0.458690772916403 1.26273740963117 0.4 16.3 16 3 decreased body size 5.40351771348156e-24 3.36031257807134e-21 1.26194622077802 0.399749373433584 16.3 16 3 decreased circulating cholesterol level 1.43164114795879e-06 4.78730390479956e-05 1.25928730741907 0.398907103825137 16.3 16 3 polydactyly 0.000391986906612483 0.00589164610391875 1.25629487182693 0.397959183673469 16.3 16 3 hypoactivity 7.59374113248611e-12 7.55577242682368e-10 1.25603853743154 0.397877984084881 16.3 16 3 abnormal brain morphology 7.04376639427801e-06 0.000192542515447984 1.25489432013036 0.397515527950311 16.3 16 3 abnormal heart ventricle morphology 0.00151479595904369 0.0179859424731321 1.25464293905661 0.397435897435897 16.3 16 3 decreased body weight 9.09529997262404e-36 9.04982347276092e-33 1.25457755561094 0.397415185783522 16.3 16 3 seminiferous tubule degeneration 0.00213161368879916 0.0239927106375019 1.25408852326384 0.397260273972603 16.3 16 3 reduced female fertility 9.2553929029744e-08 4.14825042272952e-06 1.25185174230677 0.396551724137931 16.3 16 3 abnormal embryonic neuroepithelium morphology 0.00601400671625112 0.0541586069603921 1.25185174230677 0.396551724137931 16.3 16 3 glomerulosclerosis 0.00601400671625112 0.0541586069603921 1.25185174230677 0.396551724137931 16.3 16 3 abnormal coat/ hair morphology 0.008543375360769 0.0716750293757602 1.25082479255918 0.39622641509434 16.3 16 3 abnormal mesoderm development 0.008543375360769 0.0716750293757602 1.25082479255918 0.39622641509434 16.3 16 3 abnormal lymph node morphology 0.012179161680713 0.0926472926017538 1.24958389494751 0.395833333333333 16.3 16 3 delayed endochondral bone ossification 0.0174360777171395 0.118503397052963 1.24805441649593 0.395348837209302 16.3 16 3 decreased heart weight 0.00144209600363143 0.017329535309339 1.24714805889499 0.395061728395062 16.3 16 3 abnormal trabecular bone morphology 0.00013105100996494 0.00245104802472021 1.24682055152658 0.394957983193277 16.3 16 3 decreased circulating glucose level 7.95054672522515e-09 4.25311504924679e-07 1.24463364748592 0.39426523297491 16.3 16 3 cachexia 0.000356308354316367 0.00547109278618496 1.24452485083842 0.394230769230769 16.3 16 3 decreased body length 1.09962345484341e-08 5.75855440825889e-07 1.24430328686283 0.394160583941606 16.3 16 3 belly spot 0.0363539110212699 0.200067154127011 1.24360502463676 0.393939393939394 16.3 16 3 abnormal locomotor coordination 0.0363539110212699 0.200067154127011 1.24360502463676 0.393939393939394 16.3 16 3 abnormal QRS complex 0.0363539110212699 0.200067154127011 1.24360502463676 0.393939393939394 16.3 16 3 cardiovascular system phenotype 0.0363539110212699 0.200067154127011 1.24360502463676 0.393939393939394 16.3 16 3 decreased sensitivity to xenobiotic induced morbidity/mortality 0.0363539110212699 0.200067154127011 1.24360502463676 0.393939393939394 16.3 16 3 increased startle reflex 0.000976965269129123 0.0126244213348504 1.24145531845761 0.393258426966292 16.3 16 3 abnormal blood vessel morphology 3.17073300934968e-05 0.000696644989098665 1.24096607498236 0.393103448275862 16.3 16 3 abnormal coat/hair pigmentation 0.000242844959908537 0.00398071965267491 1.24018852731633 0.392857142857143 16.3 16 3 hypoxia 0.0531275629181368 0.251963418034062 1.24018852731633 0.392857142857143 16.3 16 3 abnormal brainstem morphology 0.0531275629181368 0.251963418034062 1.24018852731633 0.392857142857143 16.3 16 3 hunched posture 0.0019258778904463 0.0222302610324138 1.23876138286602 0.392405063291139 16.3 16 3 distended abdomen 0.0115171970506233 0.0882866800105562 1.23797785257958 0.392156862745098 16.3 16 3 abnormal gluconeogenesis 0.0115171970506233 0.0882866800105562 1.23797785257958 0.392156862745098 16.3 16 3 increased sensitivity to induced morbidity/mortality 3.8315015854396e-06 0.000113462621354536 1.23528659637832 0.391304347826087 16.3 16 3 abnormal skeleton morphology 0.000230939170586157 0.00388149450562882 1.23528659637832 0.391304347826087 16.3 16 3 dilated heart 0.078568817793413 0.326549597762932 1.23528659637832 0.391304347826087 16.3 16 3 abnormal hepatocyte physiology 0.078568817793413 0.326549597762932 1.23528659637832 0.391304347826087 16.3 16 3 scaly skin 0.0236211440311466 0.144190419085834 1.23193893622553 0.390243902439024 16.3 16 3 increased tumor growth/size 0.0236211440311466 0.144190419085834 1.23193893622553 0.390243902439024 16.3 16 3 palatal shelves fail to meet at midline 0.0236211440311466 0.144190419085834 1.23193893622553 0.390243902439024 16.3 16 3 oxidative stress 0.00123317364650442 0.0150368600278419 1.22766137047475 0.388888888888889 16.3 16 3 abnormal retinal blood vessel morphology 0.0341084708310173 0.189597365792527 1.22766137047475 0.388888888888889 16.3 16 3 abnormal redox activity 0.118219952545565 0.429302382419114 1.22766137047475 0.388888888888889 16.3 16 3 decreased heart rate variability 0.118219952545565 0.429302382419114 1.22766137047475 0.388888888888889 16.3 16 3 long tibia 0.118219952545565 0.429302382419114 1.22766137047475 0.388888888888889 16.3 16 3 abnormal glycogen homeostasis 0.118219952545565 0.429302382419114 1.22766137047475 0.388888888888889 16.3 16 3 abnormal sperm axoneme morphology 0.118219952545565 0.429302382419114 1.22766137047475 0.388888888888889 16.3 16 3 abnormal aerobic respiration 0.118219952545565 0.429302382419114 1.22766137047475 0.388888888888889 16.3 16 3 decreased fluid intake 0.118219952545565 0.429302382419114 1.22766137047475 0.388888888888889 16.3 16 3 impaired leukocyte tethering or rolling 0.118219952545565 0.429302382419114 1.22766137047475 0.388888888888889 16.3 16 3 decreased circulating creatinine level 0.0154958067731384 0.108579772811779 1.22408218280573 0.387755102040816 16.3 16 3 abnormal retinal pigment epithelium morphology 0.00242943810487851 0.026858787937268 1.2232768655802 0.3875 16.3 16 3 postnatal lethality, incomplete penetrance 3.41720590525128e-15 6.07164263522326e-13 1.22272108326962 0.387323943661972 16.3 16 3 autoimmune response 0.0496257664806541 0.237392488693514 1.22200394480436 0.387096774193548 16.3 16 3 increased lung adenoma incidence 0.0496257664806541 0.237392488693514 1.22200394480436 0.387096774193548 16.3 16 3 pale kidney 0.0496257664806541 0.237392488693514 1.22200394480436 0.387096774193548 16.3 16 3 delayed bone ossification 0.00341780091735639 0.0348023044496038 1.22064616264347 0.386666666666667 16.3 16 3 omphalocele 0.022186472396719 0.142151738488286 1.21968954339375 0.386363636363636 16.3 16 3 abnormal pulmonary alveolus morphology 0.000789617582421846 0.0107077659227094 1.21897918256475 0.386138613861386 16.3 16 3 abnormal craniofacial bone morphology 0.0102388062668139 0.0844743966457698 1.21843083385464 0.385964912280702 16.3 16 3 abnormal rib morphology 0.000127362503586359 0.00240010778538688 1.21596935742261 0.385185185185185 16.3 16 3 decreased bone mineral content 2.53931721130775e-06 8.09814302965132e-05 1.21417058618382 0.384615384615385 16.3 16 3 eyelids open at birth 0.0145669566007934 0.103529441555639 1.21417058618382 0.384615384615385 16.3 16 3 abnormal heart looping 0.0319314783366343 0.18267735089041 1.21417058618382 0.384615384615385 16.3 16 3 no spontaneous movement 0.0729325520576984 0.304651088570151 1.21417058618382 0.384615384615385 16.3 16 3 abnormal ocular fundus morphology 0.0729325520576984 0.304651088570151 1.21417058618382 0.384615384615385 16.3 16 3 abnormal erythrocyte osmotic lysis 0.0729325520576984 0.304651088570151 1.21417058618382 0.384615384615385 16.3 16 3 excessive scratching 0.182875202262558 0.547744811111514 1.21417058618382 0.384615384615385 16.3 16 3 abnormal digestion 0.182875202262558 0.547744811111514 1.21417058618382 0.384615384615385 16.3 16 3 abnormal pulmonary alveolus epithelial cell morphology 0.182875202262558 0.547744811111514 1.21417058618382 0.384615384615385 16.3 16 3 abnormal lung interstitium morphology 0.182875202262558 0.547744811111514 1.21417058618382 0.384615384615385 16.3 16 3 abnormal tail bud morphology 0.182875202262558 0.547744811111514 1.21417058618382 0.384615384615385 16.3 16 3 abnormal bile duct development 0.182875202262558 0.547744811111514 1.21417058618382 0.384615384615385 16.3 16 3 anal atresia 0.182875202262558 0.547744811111514 1.21417058618382 0.384615384615385 16.3 16 3 abnormal GABAergic neuron morphology 0.182875202262558 0.547744811111514 1.21417058618382 0.384615384615385 16.3 16 3 tracheoesophageal fistula 0.182875202262558 0.547744811111514 1.21417058618382 0.384615384615385 16.3 16 3 muscle fatigue 0.182875202262558 0.547744811111514 1.21417058618382 0.384615384615385 16.3 16 3 abnormal retinal inner plexiform layer morphology 0.182875202262558 0.547744811111514 1.21417058618382 0.384615384615385 16.3 16 3 increased circulating thyroid-stimulating hormone level 0.182875202262558 0.547744811111514 1.21417058618382 0.384615384615385 16.3 16 3 abnormal vertebral arch development 0.182875202262558 0.547744811111514 1.21417058618382 0.384615384615385 16.3 16 3 small pituitary gland 0.182875202262558 0.547744811111514 1.21417058618382 0.384615384615385 16.3 16 3 increased circulating thyroxine level 0.182875202262558 0.547744811111514 1.21417058618382 0.384615384615385 16.3 16 3 abnormal aorta tunica media morphology 0.182875202262558 0.547744811111514 1.21417058618382 0.384615384615385 16.3 16 3 abnormal gut flora balance 0.182875202262558 0.547744811111514 1.21417058618382 0.384615384615385 16.3 16 3 small testis 7.26846881074919e-08 3.28733021213429e-06 1.21241091866761 0.384057971014493 16.3 16 3 azoospermia 4.03802647630343e-05 0.000869661546303444 1.21111606898587 0.383647798742138 16.3 16 3 abnormal skeleton development 0.00304159020765171 0.0322642031621903 1.20817468205452 0.382716049382716 16.3 16 3 lung hemorrhage 0.0462586793780344 0.224401663679248 1.20702840626509 0.382352941176471 16.3 16 3 overexpanded pulmonary alveoli 0.0462586793780344 0.224401663679248 1.20702840626509 0.382352941176471 16.3 16 3 abnormal vision 0.0462586793780344 0.224401663679248 1.20702840626509 0.382352941176471 16.3 16 3 decreased regulatory T cell number 0.0462586793780344 0.224401663679248 1.20702840626509 0.382352941176471 16.3 16 3 decreased cytotoxic T cell cytolysis 0.0462586793780344 0.224401663679248 1.20702840626509 0.382352941176471 16.3 16 3 increased susceptibility to viral infection induced morbidity/mortality 0.0462586793780344 0.224401663679248 1.20702840626509 0.382352941176471 16.3 16 3 respiratory distress 2.46724950370518e-05 0.000560482478581428 1.20434492826094 0.38150289017341 16.3 16 3 abnormal myocardial fiber morphology 0.00137661837877056 0.0167040888643501 1.20415680815344 0.381443298969072 16.3 16 3 increased heart weight 0.000149699118249517 0.00276859893416858 1.20368853795777 0.381294964028777 16.3 16 3 abnormal muscle morphology 0.0298437448484902 0.176124116988421 1.20260705679159 0.380952380952381 16.3 16 3 abnormal embryonic/fetal subventricular zone morphology 0.108703892125153 0.400593972831583 1.20260705679159 0.380952380952381 16.3 16 3 increased bone ossification 0.108703892125153 0.400593972831583 1.20260705679159 0.380952380952381 16.3 16 3 neonatal lethality, incomplete penetrance 3.08879993658511e-07 1.26998179210834e-05 1.20202888032198 0.380769230769231 16.3 16 3 increased bone mineral density 0.000628544992519678 0.00875913539995909 1.20127673925089 0.380530973451327 16.3 16 3 abnormal skeletal muscle fiber morphology 0.00602004214052197 0.0541586069603921 1.20048979084654 0.380281690140845 16.3 16 3 increased body length 0.0194782033259353 0.129550884420492 1.19960053914961 0.38 16.3 16 3 decreased circulating alkaline phosphatase level 0.0194782033259353 0.129550884420492 1.19960053914961 0.38 16.3 16 3 postnatal lethality 4.46849135732269e-05 0.000941980699266118 1.19807916877656 0.379518072289157 16.3 16 3 abnormal spermiogenesis 0.0128206282143802 0.0969846564570448 1.19742340568473 0.379310344827586 16.3 16 3 abnormal spinal nerve morphology 0.0675864987741954 0.284951552035273 1.19742340568473 0.379310344827586 16.3 16 3 stomach inflammation 0.0675864987741954 0.284951552035273 1.19742340568473 0.379310344827586 16.3 16 3 decreased birth weight 0.0018129122260551 0.0211223379967778 1.19627754596637 0.378947368421053 16.3 16 3 insulin resistance 0.000272439315109355 0.00435815303109016 1.19577406215073 0.378787878787879 16.3 16 3 impaired skeletal muscle contractility 0.0430568087462535 0.224401663679248 1.19448133343489 0.378378378378378 16.3 16 3 abnormal chromosome morphology 0.0430568087462535 0.224401663679248 1.19448133343489 0.378378378378378 16.3 16 3 abnormal hair follicle development 0.0430568087462535 0.224401663679248 1.19448133343489 0.378378378378378 16.3 16 3 altered response to myocardial infarction 0.0278569806283361 0.167986034698148 1.19258533131833 0.377777777777778 16.3 16 3 abnormal long bone morphology 0.0120084872744973 0.0917699296322948 1.19028526317693 0.377049180327869 16.3 16 3 abnormal lung development 0.00355049627956245 0.0360484061037208 1.1884587384764 0.376470588235294 16.3 16 3 cyanosis 2.14498644169229e-05 0.000503363563557506 1.18381632152922 0.375 16.3 16 3 abnormal body weight 0.0998889193041232 0.376080650194594 1.18381632152922 0.375 16.3 16 3 abnormal primitive streak formation 0.0998889193041232 0.376080650194594 1.18381632152922 0.375 16.3 16 3 abnormal retinal ganglion layer morphology 0.0998889193041232 0.376080650194594 1.18381632152922 0.375 16.3 16 3 increased circulating total protein level 0.0998889193041232 0.376080650194594 1.18381632152922 0.375 16.3 16 3 abnormal truncus arteriosus septation 0.0998889193041232 0.376080650194594 1.18381632152922 0.375 16.3 16 3 abnormal lung saccule morphology 0.0998889193041232 0.376080650194594 1.18381632152922 0.375 16.3 16 3 abnormal spermatogenesis 3.14253566016867e-05 0.000694849551526184 1.18381632152922 0.375 16.3 16 3 decreased circulating HDL cholesterol level 0.000465679943619737 0.00682201914614027 1.18381632152922 0.375 16.3 16 3 increased liver weight 0.00333248434285769 0.0345500606400138 1.18381632152922 0.375 16.3 16 3 abnormal skin pigmentation 0.0400345564821037 0.217912383477534 1.18381632152922 0.375 16.3 16 3 abnormal auditory brainstem response waveform shape 0.0625676966575856 0.27233096314216 1.18381632152922 0.375 16.3 16 3 vasculature congestion 0.165481606033441 0.505384278708638 1.18381632152922 0.375 16.3 16 3 abnormal hair follicle orientation 0.165481606033441 0.505384278708638 1.18381632152922 0.375 16.3 16 3 mixed cellular infiltration to dermis 0.165481606033441 0.505384278708638 1.18381632152922 0.375 16.3 16 3 poor circulation 0.165481606033441 0.505384278708638 1.18381632152922 0.375 16.3 16 3 white spotting 0.165481606033441 0.505384278708638 1.18381632152922 0.375 16.3 16 3 increased intestinal adenocarcinoma incidence 0.165481606033441 0.505384278708638 1.18381632152922 0.375 16.3 16 3 increased pancreatic beta cell number 0.165481606033441 0.505384278708638 1.18381632152922 0.375 16.3 16 3 increased heart left ventricle size 0.165481606033441 0.505384278708638 1.18381632152922 0.375 16.3 16 3 decreased adipocyte glucose uptake 0.165481606033441 0.505384278708638 1.18381632152922 0.375 16.3 16 3 reduced fertility 0.000297093882558079 0.00469219703405219 1.180977433468 0.37410071942446 16.3 16 3 short tail 0.00466528369001282 0.0447462799902309 1.17906203911344 0.373493975903614 16.3 16 3 no abnormal phenotype detected 4.77794940082179e-37 5.9425745672721e-34 1.17904011735014 0.373487031700288 16.3 16 3 abnormal response to novel object 0.0242050508019018 0.147393057208643 1.1760789599506 0.372549019607843 16.3 16 3 failure of chorioallantoic fusion 0.0242050508019018 0.147393057208643 1.1760789599506 0.372549019607843 16.3 16 3 abnormal organ of Corti morphology 0.0371964364818832 0.20380206112045 1.1746394508197 0.372093023255814 16.3 16 3 kidney failure 0.0371964364818832 0.20380206112045 1.1746394508197 0.372093023255814 16.3 16 3 increased urine protein level 0.00653884361547076 0.0586139585350757 1.17369823331103 0.371794871794872 16.3 16 3 increased circulating serum albumin level 0.0578857758658078 0.257817130646727 1.1725418803718 0.371428571428571 16.3 16 3 abnormal intestinal goblet cell morphology 0.0578857758658078 0.257817130646727 1.1725418803718 0.371428571428571 16.3 16 3 decreased triglyceride level 0.0578857758658078 0.257817130646727 1.1725418803718 0.371428571428571 16.3 16 3 abnormal muscle physiology 0.00409198589654572 0.0399821165996755 1.17051501454575 0.370786516853933 16.3 16 3 diluted coat color 0.0225405552815371 0.142151738488286 1.16920130521405 0.37037037037037 16.3 16 3 abnormal maxilla morphology 0.0225405552815371 0.142151738488286 1.16920130521405 0.37037037037037 16.3 16 3 abnormal neuronal precursor proliferation 0.0225405552815371 0.142151738488286 1.16920130521405 0.37037037037037 16.3 16 3 abnormal trigeminal nerve morphology 0.0917810218100572 0.368326074586212 1.16920130521405 0.37037037037037 16.3 16 3 abnormal trigeminal ganglion morphology 0.0917810218100572 0.368326074586212 1.16920130521405 0.37037037037037 16.3 16 3 abnormal brain commissure morphology 0.0917810218100572 0.368326074586212 1.16920130521405 0.37037037037037 16.3 16 3 thick interventricular septum 0.0917810218100572 0.368326074586212 1.16920130521405 0.37037037037037 16.3 16 3 enlarged liver 0.00257266291146601 0.0282538586855262 1.16803210390883 0.37 16.3 16 3 abnormal inner ear morphology 0.0345408828934252 0.191572901220502 1.16665956324619 0.369565217391304 16.3 16 3 persistence of hyaloid vascular system 0.0535355297696949 0.253656438670697 1.16304761413397 0.368421052631579 16.3 16 3 delayed sexual maturation 0.15007346521213 0.475854359101559 1.16304761413397 0.368421052631579 16.3 16 3 abnormal nasal septum morphology 0.15007346521213 0.475854359101559 1.16304761413397 0.368421052631579 16.3 16 3 abnormal response to novelty 0.15007346521213 0.475854359101559 1.16304761413397 0.368421052631579 16.3 16 3 increased left ventricle weight 0.15007346521213 0.475854359101559 1.16304761413397 0.368421052631579 16.3 16 3 increased liver cholesterol level 0.15007346521213 0.475854359101559 1.16304761413397 0.368421052631579 16.3 16 3 decreased circulating magnesium level 0.15007346521213 0.475854359101559 1.16304761413397 0.368421052631579 16.3 16 3 decreased susceptibility to weight gain 0.15007346521213 0.475854359101559 1.16304761413397 0.368421052631579 16.3 16 3 shortened RR interval 0.15007346521213 0.475854359101559 1.16304761413397 0.368421052631579 16.3 16 3 thin interventricular septum 0.15007346521213 0.475854359101559 1.16304761413397 0.368421052631579 16.3 16 3 abnormal retinal pigmentation 0.00534424316362415 0.0504508723700762 1.16113784793671 0.367816091954023 16.3 16 3 increased circulating LDL cholesterol level 0.0320626351196929 0.18267735089041 1.15965680476332 0.36734693877551 16.3 16 3 Leydig cell hyperplasia 0.0495038328961174 0.237392488693514 1.15494275271144 0.365853658536585 16.3 16 3 abnormal cholesterol homeostasis 0.0495038328961174 0.237392488693514 1.15494275271144 0.365853658536585 16.3 16 3 abnormal hair growth 0.0297542565540549 0.175804544366298 1.15346205687463 0.365384615384615 16.3 16 3 abnormal brain wave pattern 0.0297542565540549 0.175804544366298 1.15346205687463 0.365384615384615 16.3 16 3 skin lesions 0.0181585608483272 0.123077438992409 1.15249842942528 0.365079365079365 16.3 16 3 hyperactivity 6.25544928147634e-08 2.90849160517241e-06 1.14871664622782 0.363881401617251 16.3 16 3 abnormal contextual conditioning behavior 0.0276071127553407 0.166681293638131 1.1479430996647 0.363636363636364 16.3 16 3 abnormal learning/memory/conditioning 0.0276071127553407 0.166681293638131 1.1479430996647 0.363636363636364 16.3 16 3 abnormal joint morphology 0.0276071127553407 0.166681293638131 1.1479430996647 0.363636363636364 16.3 16 3 abnormal circadian rhythm 0.0457735588162626 0.224401663679248 1.1479430996647 0.363636363636364 16.3 16 3 single kidney 0.0775470027354804 0.322842124359008 1.1479430996647 0.363636363636364 16.3 16 3 increased osteoblast cell number 0.0775470027354804 0.322842124359008 1.1479430996647 0.363636363636364 16.3 16 3 abnormal enterocyte morphology 0.136384780014408 0.473646598823551 1.1479430996647 0.363636363636364 16.3 16 3 abnormal tail movements 0.136384780014408 0.473646598823551 1.1479430996647 0.363636363636364 16.3 16 3 abnormal chorion morphology 0.136384780014408 0.473646598823551 1.1479430996647 0.363636363636364 16.3 16 3 increased coping response 0.136384780014408 0.473646598823551 1.1479430996647 0.363636363636364 16.3 16 3 aphakia 0.136384780014408 0.473646598823551 1.1479430996647 0.363636363636364 16.3 16 3 abnormal retinal outer plexiform layer morphology 0.136384780014408 0.473646598823551 1.1479430996647 0.363636363636364 16.3 16 3 prolonged PR interval 0.136384780014408 0.473646598823551 1.1479430996647 0.363636363636364 16.3 16 3 abnormal limb posture 0.136384780014408 0.473646598823551 1.1479430996647 0.363636363636364 16.3 16 3 abnormal blood-brain barrier function 0.136384780014408 0.473646598823551 1.1479430996647 0.363636363636364 16.3 16 3 abnormal coat appearance 0.0157017713310906 0.109027526453549 1.14378388553548 0.36231884057971 16.3 16 3 increased respiratory quotient 0.042325839582064 0.224401663679248 1.14183701934734 0.361702127659574 16.3 16 3 increased circulating glucose level 0.000834874140325389 0.0109590998631103 1.14183701934734 0.361702127659574 16.3 16 3 perinatal lethality, complete penetrance 4.94111161530773e-05 0.00102425126192316 1.14120634438498 0.36150234741784 16.3 16 3 abnormal cardiovascular system physiology 0.00123002572599645 0.0150353267489738 1.1393119485394 0.360902255639098 16.3 16 3 increased circulating chloride level 0.0391413780036816 0.213517933737189 1.13646366866806 0.36 16.3 16 3 decreased respiratory quotient 0.0391413780036816 0.213517933737189 1.13646366866806 0.36 16.3 16 3 abnormal thyroid gland morphology 0.124178741149157 0.449301263430588 1.13646366866806 0.36 16.3 16 3 abnormal keratinocyte physiology 0.124178741149157 0.449301263430588 1.13646366866806 0.36 16.3 16 3 abnormal preimplantation embryo development 0.124178741149157 0.449301263430588 1.13646366866806 0.36 16.3 16 3 decreased litter size 4.95559999806483e-06 0.000140880628516414 1.13466617769349 0.359430604982206 16.3 16 3 abnormal lens morphology 0.00169373278222557 0.0197800952853808 1.13449064146551 0.359375 16.3 16 3 decreased startle reflex 0.00268122737209469 0.0293812911369407 1.13322588043823 0.358974358974359 16.3 16 3 increased circulating alanine transaminase level 0.012613937187638 0.0956620998605167 1.13322588043823 0.358974358974359 16.3 16 3 increased circulating bilirubin level 0.0362012050384452 0.200067154127011 1.13169862183926 0.358490566037736 16.3 16 3 impaired coordination 5.36200444747903e-07 2.0209069792582e-05 1.13135432654816 0.358381502890173 16.3 16 3 increased total body fat amount 0.00147507515393803 0.0175983186830736 1.13080962056523 0.358208955223881 16.3 16 3 increased exploration in new environment 0.0117245553673768 0.0897379430041535 1.13022792837358 0.358024691358025 16.3 16 3 male infertility 1.94101833109903e-09 1.25409950613216e-07 1.12968555533604 0.357852882703777 16.3 16 3 decreased anxiety-related response 0.00233171220507049 0.025893455848718 1.12927735820674 0.357723577235772 16.3 16 3 neonatal lethality, complete penetrance 1.19879784961843e-08 6.21252010609553e-07 1.12843310180856 0.357456140350877 16.3 16 3 arrest of spermatogenesis 0.0108975671763051 0.0871630172059773 1.12744411574212 0.357142857142857 16.3 16 3 reddish skin 0.113255165638902 0.414907547167553 1.12744411574212 0.357142857142857 16.3 16 3 absent corpus callosum 0.113255165638902 0.414907547167553 1.12744411574212 0.357142857142857 16.3 16 3 failure of blastocyst to hatch from the zona pellucida 0.113255165638902 0.414907547167553 1.12744411574212 0.357142857142857 16.3 16 3 abnormal retinal inner nuclear layer morphology 0.113255165638902 0.414907547167553 1.12744411574212 0.357142857142857 16.3 16 3 premature aging 0.113255165638902 0.414907547167553 1.12744411574212 0.357142857142857 16.3 16 3 abnormal interparietal bone morphology 0.231283300207767 0.558094926145319 1.12744411574212 0.357142857142857 16.3 16 3 abnormal zigzag hair morphology 0.231283300207767 0.558094926145319 1.12744411574212 0.357142857142857 16.3 16 3 abnormal ventral body wall morphology 0.231283300207767 0.558094926145319 1.12744411574212 0.357142857142857 16.3 16 3 failure of zygotic cell division 0.231283300207767 0.558094926145319 1.12744411574212 0.357142857142857 16.3 16 3 abnormal imprinting 0.231283300207767 0.558094926145319 1.12744411574212 0.357142857142857 16.3 16 3 abnormal pancreas development 0.231283300207767 0.558094926145319 1.12744411574212 0.357142857142857 16.3 16 3 abnormal iris pigmentation 0.231283300207767 0.558094926145319 1.12744411574212 0.357142857142857 16.3 16 3 reduced male fertility 5.39805827265628e-05 0.00110972478952335 1.12645077290887 0.356828193832599 16.3 16 3 abnormal motor capabilities/coordination/movement 0.00188990812445319 0.0218657974864061 1.12402761842169 0.356060606060606 16.3 16 3 abnormal cranial ganglia morphology 0.103446728380868 0.382353249401798 1.12017028273733 0.354838709677419 16.3 16 3 abnormal eyelid morphology 0.103446728380868 0.382353249401798 1.12017028273733 0.354838709677419 16.3 16 3 abnormal retinal photoreceptor layer morphology 0.103446728380868 0.382353249401798 1.12017028273733 0.354838709677419 16.3 16 3 decreased susceptibility to bacterial infection induced morbidity/mortality 0.103446728380868 0.382353249401798 1.12017028273733 0.354838709677419 16.3 16 3 abnormal intestinal epithelium morphology 0.0512914082398657 0.24418636937161 1.11804874811093 0.354166666666667 16.3 16 3 female infertility 2.23428066161561e-05 0.000517002153094774 1.11557628294483 0.353383458646617 16.3 16 3 abnormal cervical vertebrae morphology 0.0472884655682888 0.22730446009878 1.11418006732162 0.352941176470588 16.3 16 3 increased or absent threshold for auditory brainstem response 1.09532307333334e-05 0.000279447809735044 1.11418006732162 0.352941176470588 16.3 16 3 decreased osteoblast cell number 0.0946133609304508 0.370092940292832 1.11418006732162 0.352941176470588 16.3 16 3 increased susceptibility to weight gain 0.0946133609304508 0.370092940292832 1.11418006732162 0.352941176470588 16.3 16 3 increased incidence of corneal inflammation 0.206511405680455 0.558094926145319 1.11418006732162 0.352941176470588 16.3 16 3 abnormal heart rate 0.206511405680455 0.558094926145319 1.11418006732162 0.352941176470588 16.3 16 3 abnormal glutamate-mediated receptor currents 0.206511405680455 0.558094926145319 1.11418006732162 0.352941176470588 16.3 16 3 decreased vasoconstriction 0.206511405680455 0.558094926145319 1.11418006732162 0.352941176470588 16.3 16 3 abnormal testis development 0.206511405680455 0.558094926145319 1.11418006732162 0.352941176470588 16.3 16 3 abnormal survival 0.206511405680455 0.558094926145319 1.11418006732162 0.352941176470588 16.3 16 3 delayed heart development 0.206511405680455 0.558094926145319 1.11418006732162 0.352941176470588 16.3 16 3 abnormal gait 5.75494788188482e-06 0.000160500615672444 1.11357910719901 0.352750809061489 16.3 16 3 abnormal suckling behavior 0.0121056758321472 0.092229306684429 1.11206987780018 0.352272727272727 16.3 16 3 teratozoospermia 0.0121056758321472 0.092229306684429 1.11206987780018 0.352272727272727 16.3 16 3 corneal opacity 0.0227427386091673 0.142151738488286 1.1115646211542 0.352112676056338 16.3 16 3 abnormal long bone epiphyseal plate proliferative zone 0.0436169863350527 0.224401663679248 1.11074123995335 0.351851851851852 16.3 16 3 abnormal osteoblast physiology 0.0436169863350527 0.224401663679248 1.11074123995335 0.351851851851852 16.3 16 3 small seminiferous tubules 0.0210612884166394 0.138597764381985 1.10916123818954 0.351351351351351 16.3 16 3 kidney cysts 0.0210612884166394 0.138597764381985 1.10916123818954 0.351351351351351 16.3 16 3 abnormal branching of the mammary ductal tree 0.0866371253050849 0.356214626770907 1.10916123818954 0.351351351351351 16.3 16 3 abnormal pancreatic beta cell physiology 0.0866371253050849 0.356214626770907 1.10916123818954 0.351351351351351 16.3 16 3 anencephaly 0.185432298805672 0.552741573731705 1.10489523342728 0.35 16.3 16 3 abnormal hearing physiology 0.185432298805672 0.552741573731705 1.10489523342728 0.35 16.3 16 3 abnormal hair texture 0.185432298805672 0.552741573731705 1.10489523342728 0.35 16.3 16 3 decreased circulating VLDL cholesterol level 0.185432298805672 0.552741573731705 1.10489523342728 0.35 16.3 16 3 abnormal long bone epiphyseal plate morphology 0.037152810157362 0.20380206112045 1.10489523342728 0.35 16.3 16 3 increased circulating aspartate transaminase level 0.0343091660031182 0.190500112573117 1.10238980205896 0.349206349206349 16.3 16 3 abnormal double-strand DNA break repair 0.0728705687935835 0.304651088570151 1.10122448514346 0.348837209302326 16.3 16 3 abnormal kidney morphology 0.000832484630819165 0.0109566429585327 1.10038545696431 0.348571428571429 16.3 16 3 abnormal tail morphology 0.0316945548976516 0.18267735089041 1.10011213717867 0.348484848484849 16.3 16 3 abnormal sternum morphology 0.0292891893568265 0.174090462425581 1.09803253011406 0.347826086956522 16.3 16 3 abnormal pulmonary artery morphology 0.167219959865606 0.510379938853614 1.09803253011406 0.347826086956522 16.3 16 3 abnormal neurocranium morphology 0.0250361829281106 0.152267738468643 1.09437242168035 0.346666666666667 16.3 16 3 microphthalmia 0.00204280822089253 0.0233631514918169 1.09354710311196 0.34640522875817 16.3 16 3 increased susceptibility to injury 0.056571282105236 0.257817130646727 1.09275352756544 0.346153846153846 16.3 16 3 abnormal kidney cortex morphology 0.151309076550518 0.476795493068379 1.09275352756544 0.346153846153846 16.3 16 3 abnormal nerve conduction 0.151309076550518 0.476795493068379 1.09275352756544 0.346153846153846 16.3 16 3 abnormal head morphology 0.0520666418354559 0.247403575101617 1.09054594468147 0.345454545454545 16.3 16 3 increased blood urea nitrogen level 0.0029820311890893 0.0317000110378617 1.08856673244067 0.344827586206897 16.3 16 3 abnormal parietal bone morphology 0.137291306094011 0.473646598823551 1.08856673244067 0.344827586206897 16.3 16 3 abnormal circulating glucose level 0.137291306094011 0.473646598823551 1.08856673244067 0.344827586206897 16.3 16 3 focal hair loss 0.137291306094011 0.473646598823551 1.08856673244067 0.344827586206897 16.3 16 3 short sternum 0.137291306094011 0.473646598823551 1.08856673244067 0.344827586206897 16.3 16 3 lethargy 0.0157405024290328 0.109027526453549 1.08622572871499 0.344086021505376 16.3 16 3 abnormal crypts of Lieberkuhn morphology 0.124859554521636 0.45078104771055 1.08516496140179 0.34375 16.3 16 3 abnormal diaphragm morphology 0.124859554521636 0.45078104771055 1.08516496140179 0.34375 16.3 16 3 pancreatic islet hyperplasia 0.124859554521636 0.45078104771055 1.08516496140179 0.34375 16.3 16 3 abnormal artery morphology 0.113775579225047 0.416201107826919 1.08234635111243 0.342857142857143 16.3 16 3 decreased glycogen level 0.113775579225047 0.416201107826919 1.08234635111243 0.342857142857143 16.3 16 3 abnormal fertility/fecundity 0.0320118830070013 0.18267735089041 1.0811107959171 0.342465753424658 16.3 16 3 abnormal frontal bone morphology 0.103849954983488 0.383558668183261 1.07997278455298 0.342105263157895 16.3 16 3 abnormal response/metabolism to endogenous compounds 0.0252472914993938 0.153364194394974 1.07794656919734 0.341463414634146 16.3 16 3 abnormal mammary gland development 0.094929058495026 0.370092940292832 1.07794656919734 0.341463414634146 16.3 16 3 short humerus 0.094929058495026 0.370092940292832 1.07794656919734 0.341463414634146 16.3 16 3 lethality at weaning, incomplete penetrance 0.094929058495026 0.370092940292832 1.07794656919734 0.341463414634146 16.3 16 3 circling 0.0233426012018039 0.143016552929772 1.07704073174424 0.341176470588235 16.3 16 3 hyperglycemia 0.0215883488702126 0.140906270257702 1.07619665593566 0.340909090909091 16.3 16 3 hypertension 0.0868862636094392 0.356355450500379 1.07619665593566 0.340909090909091 16.3 16 3 abnormal amino acid level 0.0868862636094392 0.356355450500379 1.07619665593566 0.340909090909091 16.3 16 3 embryonic lethality, incomplete penetrance 0.0868862636094392 0.356355450500379 1.07619665593566 0.340909090909091 16.3 16 3 cleft secondary palate 0.0184815147333373 0.124587446881237 1.07467013585632 0.340425531914894 16.3 16 3 abnormal axon extension 0.0730282203616754 0.304794795553134 1.0733267981865 0.34 16.3 16 3 abnormal pancreatic islet morphology 0.0670473217395852 0.284951552035273 1.0721355364793 0.339622641509434 16.3 16 3 abnormal renal glomerulus morphology 0.0125877793028983 0.0956094687510214 1.07158908615489 0.339449541284404 16.3 16 3 postnatal lethality, complete penetrance 6.89814791367428e-06 0.000189603789339942 1.07136399392282 0.339378238341969 16.3 16 3 increased body weight 0.00052972974042643 0.00764060746047526 1.07107190995501 0.339285714285714 16.3 16 3 increased circulating free fatty acid level 0.0407672012026818 0.221415748890111 1.06710203630803 0.338028169014085 16.3 16 3 respiratory failure 0.00440084931593842 0.0423485983496975 1.0662186736952 0.337748344370861 16.3 16 3 abnormal seminiferous tubule morphology 0.00591986701835426 0.054039153057454 1.05948857999876 0.335616438356164 16.3 16 3 absent gastric milk in neonates 0.0404608168905135 0.219991873257164 1.05228117469264 0.333333333333333 16.3 16 3 abnormal food intake 0.0516923789100255 0.245860023974548 1.05228117469264 0.333333333333333 16.3 16 3 abnormal dendritic spine morphology 0.0858980977583691 0.354053882641165 1.05228117469264 0.333333333333333 16.3 16 3 abnormal kidney physiology 0.0937779667486234 0.368326074586212 1.05228117469264 0.333333333333333 16.3 16 3 irregular heartbeat 0.102500111678323 0.380267006412871 1.05228117469264 0.333333333333333 16.3 16 3 small placenta 0.102500111678323 0.380267006412871 1.05228117469264 0.333333333333333 16.3 16 3 cardiomyopathy 0.102500111678323 0.380267006412871 1.05228117469264 0.333333333333333 16.3 16 3 abnormal cartilage morphology 0.112180535725694 0.4124894051998 1.05228117469264 0.333333333333333 16.3 16 3 abnormal vibrissa morphology 0.112180535725694 0.4124894051998 1.05228117469264 0.333333333333333 16.3 16 3 increased vascular permeability 0.122958033189127 0.445857299647164 1.05228117469264 0.333333333333333 16.3 16 3 impaired wound healing 0.135000807742661 0.473646598823551 1.05228117469264 0.333333333333333 16.3 16 3 abnormal pharyngeal arch morphology 0.135000807742661 0.473646598823551 1.05228117469264 0.333333333333333 16.3 16 3 renal hypoplasia 0.135000807742661 0.473646598823551 1.05228117469264 0.333333333333333 16.3 16 3 thin epidermis 0.181073103920748 0.547744811111514 1.05228117469264 0.333333333333333 16.3 16 3 cryptorchism 0.181073103920748 0.547744811111514 1.05228117469264 0.333333333333333 16.3 16 3 decreased bone ossification 0.181073103920748 0.547744811111514 1.05228117469264 0.333333333333333 16.3 16 3 abnormal scapula morphology 0.223796502145931 0.558094926145319 1.05228117469264 0.333333333333333 16.3 16 3 abnormal salivary gland morphology 0.223796502145931 0.558094926145319 1.05228117469264 0.333333333333333 16.3 16 3 abnormal adrenal gland morphology 0.200885480146347 0.558094926145319 1.05228117469264 0.333333333333333 16.3 16 3 decreased body height 0.200885480146347 0.558094926145319 1.05228117469264 0.333333333333333 16.3 16 3 abnormal vasodilation 0.200885480146347 0.558094926145319 1.05228117469264 0.333333333333333 16.3 16 3 abnormal associative learning 0.223796502145931 0.558094926145319 1.05228117469264 0.333333333333333 16.3 16 3 abnormal cardiac muscle contractility 0.200885480146347 0.558094926145319 1.05228117469264 0.333333333333333 16.3 16 3 abnormal osteoblast morphology 0.200885480146347 0.558094926145319 1.05228117469264 0.333333333333333 16.3 16 3 abnormal bile salt homeostasis 0.223796502145931 0.558094926145319 1.05228117469264 0.333333333333333 16.3 16 3 underdeveloped hair follicles 0.2506571322479 0.566569392518539 1.05228117469264 0.333333333333333 16.3 16 3 abnormal phrenic nerve morphology 0.2506571322479 0.566569392518539 1.05228117469264 0.333333333333333 16.3 16 3 abnormal thyroid cartilage morphology 0.2506571322479 0.566569392518539 1.05228117469264 0.333333333333333 16.3 16 3 absent allantois 0.2506571322479 0.566569392518539 1.05228117469264 0.333333333333333 16.3 16 3 abnormal anterior eye segment morphology 0.2506571322479 0.566569392518539 1.05228117469264 0.333333333333333 16.3 16 3 decreased pulmonary respiratory rate 0.2506571322479 0.566569392518539 1.05228117469264 0.333333333333333 16.3 16 3 abnormal macrophage chemotaxis 0.2506571322479 0.566569392518539 1.05228117469264 0.333333333333333 16.3 16 3 increased circulating HDL cholesterol level 0.0198533402669394 0.130995182795787 1.05228117469264 0.333333333333333 16.3 16 3 abnormal aorta morphology 0.148515830414713 0.473646598823551 1.05228117469264 0.333333333333333 16.3 16 3 dextrocardia 0.148515830414713 0.473646598823551 1.05228117469264 0.333333333333333 16.3 16 3 enhanced paired-pulse facilitation 0.163762475287717 0.503223171436932 1.05228117469264 0.333333333333333 16.3 16 3 absent incisors 0.282754341678522 0.624755318122495 1.05228117469264 0.333333333333333 16.3 16 3 vagina atresia 0.282754341678522 0.624755318122495 1.05228117469264 0.333333333333333 16.3 16 3 abnormal respiratory system morphology 0.282754341678522 0.624755318122495 1.05228117469264 0.333333333333333 16.3 16 3 increased alcohol consumption 0.282754341678522 0.624755318122495 1.05228117469264 0.333333333333333 16.3 16 3 abnormal pericyte morphology 0.282754341678522 0.624755318122495 1.05228117469264 0.333333333333333 16.3 16 3 abnormal energy homeostasis 0.282754341678522 0.624755318122495 1.05228117469264 0.333333333333333 16.3 16 3 lactation failure 0.282754341678522 0.624755318122495 1.05228117469264 0.333333333333333 16.3 16 3 decreased brown adipose tissue mass 0.282754341678522 0.624755318122495 1.05228117469264 0.333333333333333 16.3 16 3 increased circulating triglyceride level 0.00849779243940495 0.0715338703655492 1.04502406314304 0.331034482758621 16.3 16 3 increased anxiety-related response 0.00987944032257237 0.0817431607966127 1.04471080652939 0.330935251798561 16.3 16 3 cataract 0.0155913525280328 0.109027526453549 1.04358463605882 0.330578512396694 16.3 16 3 short femur 0.0368295873199115 0.202460991068022 1.04032343407114 0.329545454545455 16.3 16 3 cardiac fibrosis 0.0399044592869013 0.217442152193137 1.03990139616685 0.329411764705882 16.3 16 3 abnormal axial skeleton morphology 0.0508973035293036 0.242542227067323 1.03843536976248 0.328947368421053 16.3 16 3 abnormal male meiosis 0.0772390457390556 0.322099122004863 1.03503066363211 0.327868852459016 16.3 16 3 increased circulating calcium level 0.0917496585476661 0.368326074586212 1.03314878969823 0.327272727272727 16.3 16 3 increased percent body fat/body weight 0.100142551075605 0.376080650194594 1.03204499825625 0.326923076923077 16.3 16 3 improved glucose tolerance 0.00388768212676762 0.038605226707922 1.03080604867851 0.326530612244898 16.3 16 3 alopecia 0.0361677116006291 0.200067154127011 1.03012788680438 0.326315789473684 16.3 16 3 increased circulating creatinine level 0.0459781976433755 0.224401663679248 1.02780951946723 0.325581395348837 16.3 16 3 abnormal lipid level 0.0498505330973369 0.23800998287836 1.02692500180848 0.325301204819277 16.3 16 3 obese 0.0586878047780803 0.261155481906037 1.0249491961292 0.324675324675325 16.3 16 3 increased white adipose tissue amount 0.158215375312697 0.486778906728924 1.02384114294419 0.324324324324324 16.3 16 3 abnormal ovary morphology 0.0692457635063691 0.290470213696616 1.02263945146187 0.323943661971831 16.3 16 3 short maxilla 0.174295272341969 0.530023826345535 1.02133172837815 0.323529411764706 16.3 16 3 abnormal retinal photoreceptor morphology 0.174295272341969 0.530023826345535 1.02133172837815 0.323529411764706 16.3 16 3 abnormal oocyte morphology 0.174295272341969 0.530023826345535 1.02133172837815 0.323529411764706 16.3 16 3 abnormal endoderm development 0.174295272341969 0.530023826345535 1.02133172837815 0.323529411764706 16.3 16 3 abnormal nervous system development 0.174295272341969 0.530023826345535 1.02133172837815 0.323529411764706 16.3 16 3 abnormal postnatal growth/weight/body size 0.192484259529074 0.558094926145319 1.0183366206703 0.32258064516129 16.3 16 3 decreased neuronal precursor cell number 0.192484259529074 0.558094926145319 1.0183366206703 0.32258064516129 16.3 16 3 reduced long term potentiation 0.0319229856301185 0.18267735089041 1.01469970416791 0.321428571428571 16.3 16 3 abnormal circulating cholesterol level 0.213197390475307 0.558094926145319 1.01469970416791 0.321428571428571 16.3 16 3 abnormal respiration 0.213197390475307 0.558094926145319 1.01469970416791 0.321428571428571 16.3 16 3 enhanced coordination 0.213197390475307 0.558094926145319 1.01469970416791 0.321428571428571 16.3 16 3 abnormal hormone level 0.213197390475307 0.558094926145319 1.01469970416791 0.321428571428571 16.3 16 3 increased triglyceride level 0.213197390475307 0.558094926145319 1.01469970416791 0.321428571428571 16.3 16 3 abnormal renal tubule epithelium morphology 0.213197390475307 0.558094926145319 1.01469970416791 0.321428571428571 16.3 16 3 decreased heart rate 0.0436844212739878 0.224401663679248 1.01018992770494 0.32 16.3 16 3 kidney inflammation 0.126552373453829 0.456230476762899 1.01018992770494 0.32 16.3 16 3 testicular atrophy 0.126552373453829 0.456230476762899 1.01018992770494 0.32 16.3 16 3 abnormal inner ear vestibule morphology 0.236982769086201 0.558094926145319 1.01018992770494 0.32 16.3 16 3 abnormal nest building behavior 0.236982769086201 0.558094926145319 1.01018992770494 0.32 16.3 16 3 diaphragmatic hernia 0.236982769086201 0.558094926145319 1.01018992770494 0.32 16.3 16 3 decreased placenta weight 0.236982769086201 0.558094926145319 1.01018992770494 0.32 16.3 16 3 decreased acute inflammation 0.236982769086201 0.558094926145319 1.01018992770494 0.32 16.3 16 3 abnormal energy expenditure 0.236982769086201 0.558094926145319 1.01018992770494 0.32 16.3 16 3 pulmonary hypoplasia 0.138512463720096 0.473646598823551 1.0075032523653 0.319148936170213 16.3 16 3 hyperkeratosis 0.0863332726159576 0.355553006013567 1.00652981927122 0.318840579710145 16.3 16 3 abnormal photoreceptor outer segment morphology 0.151817793322684 0.476795493068379 1.00445021220661 0.318181818181818 16.3 16 3 increased body size 0.264588639140641 0.589488795219297 1.00445021220661 0.318181818181818 16.3 16 3 abnormal cochlear sensory epithelium morphology 0.264588639140641 0.589488795219297 1.00445021220661 0.318181818181818 16.3 16 3 abnormal circulating lipid level 0.264588639140641 0.589488795219297 1.00445021220661 0.318181818181818 16.3 16 3 decreased circulating estradiol level 0.264588639140641 0.589488795219297 1.00445021220661 0.318181818181818 16.3 16 3 infertility 0.0424077725447631 0.224401663679248 1.00310915718364 0.317757009345794 16.3 16 3 abnormal facial morphology 0.121599829326272 0.441253939385999 0.996897954971978 0.315789473684211 16.3 16 3 abnormal retinal outer nuclear layer morphology 0.183307107772333 0.548378148627394 0.996897954971978 0.315789473684211 16.3 16 3 hyporesponsive to tactile stimuli 0.183307107772333 0.548378148627394 0.996897954971978 0.315789473684211 16.3 16 3 irregular coat pigmentation 0.297080363187486 0.639526990838453 0.996897954971978 0.315789473684211 16.3 16 3 stereotypic behavior 0.297080363187486 0.639526990838453 0.996897954971978 0.315789473684211 16.3 16 3 abnormal long term depression 0.297080363187486 0.639526990838453 0.996897954971978 0.315789473684211 16.3 16 3 abnormal neural crest cell migration 0.297080363187486 0.639526990838453 0.996897954971978 0.315789473684211 16.3 16 3 abnormal sternebra morphology 0.297080363187486 0.639526990838453 0.996897954971978 0.315789473684211 16.3 16 3 abnormal blastocyst morphology 0.297080363187486 0.639526990838453 0.996897954971978 0.315789473684211 16.3 16 3 eyelids fail to open 0.297080363187486 0.639526990838453 0.996897954971978 0.315789473684211 16.3 16 3 Leydig cell hypoplasia 0.297080363187486 0.639526990838453 0.996897954971978 0.315789473684211 16.3 16 3 decreased liver glycogen level 0.297080363187486 0.639526990838453 0.996897954971978 0.315789473684211 16.3 16 3 abnormal chondrocyte morphology 0.132774696909181 0.473646598823551 0.993821109431941 0.314814814814815 16.3 16 3 thick epidermis 0.0983933787646787 0.376080650194594 0.992150821853064 0.314285714285714 16.3 16 3 abnormal dermal layer morphology 0.202033465020558 0.558094926145319 0.992150821853064 0.314285714285714 16.3 16 3 decreased circulating thyroxine level 0.202033465020558 0.558094926145319 0.992150821853064 0.314285714285714 16.3 16 3 decreased bone mineralization 0.202033465020558 0.558094926145319 0.992150821853064 0.314285714285714 16.3 16 3 cochlear inner hair cell degeneration 0.145137185200326 0.473646598823551 0.990382282063665 0.313725490196078 16.3 16 3 increased circulating cholesterol level 0.0177348182811459 0.120369332808596 0.986513601274354 0.3125 16.3 16 3 abnormal neuron differentiation 0.0500717237252214 0.238836841354723 0.986513601274354 0.3125 16.3 16 3 increased circulating insulin level 0.0228614666823946 0.142151738488286 0.986513601274354 0.3125 16.3 16 3 abnormal tooth morphology 0.11653127625968 0.425655726425777 0.986513601274354 0.3125 16.3 16 3 kidney cortex cysts 0.223222761805182 0.558094926145319 0.986513601274354 0.3125 16.3 16 3 increased circulating follicle stimulating hormone level 0.223222761805182 0.558094926145319 0.986513601274354 0.3125 16.3 16 3 abnormal lumbar vertebrae morphology 0.223222761805182 0.558094926145319 0.986513601274354 0.3125 16.3 16 3 abnormal mouth morphology 0.336060130608104 0.70723314288296 0.986513601274354 0.3125 16.3 16 3 disorganized retinal layers 0.336060130608104 0.70723314288296 0.986513601274354 0.3125 16.3 16 3 abnormal extraembryonic endoderm formation 0.336060130608104 0.70723314288296 0.986513601274354 0.3125 16.3 16 3 abnormal olfaction 0.336060130608104 0.70723314288296 0.986513601274354 0.3125 16.3 16 3 bowed tibia 0.336060130608104 0.70723314288296 0.986513601274354 0.3125 16.3 16 3 small epididymis 0.336060130608104 0.70723314288296 0.986513601274354 0.3125 16.3 16 3 abnormal wound healing 0.336060130608104 0.70723314288296 0.986513601274354 0.3125 16.3 16 3 decreased creatinine clearance 0.336060130608104 0.70723314288296 0.986513601274354 0.3125 16.3 16 3 abnormal thoracic cage shape 0.336060130608104 0.70723314288296 0.986513601274354 0.3125 16.3 16 3 dilated respiratory conducting tubes 0.336060130608104 0.70723314288296 0.986513601274354 0.3125 16.3 16 3 abnormal pulmonary alveolus wall morphology 0.336060130608104 0.70723314288296 0.986513601274354 0.3125 16.3 16 3 abnormal intestine morphology 0.102582499644944 0.380289072826822 0.981181095321519 0.310810810810811 16.3 16 3 increased retinal apoptosis 0.24735512844689 0.561145355231772 0.979710059196599 0.310344827586207 16.3 16 3 decreased liver weight 0.111480063166369 0.410520587899843 0.978176866615697 0.309859154929577 16.3 16 3 decreased cardiac muscle contractility 0.0709570464491152 0.297397898975862 0.971336468947056 0.307692307692308 16.3 16 3 abnormal excitatory postsynaptic currents 0.106524414972317 0.393144632408958 0.971336468947056 0.307692307692308 16.3 16 3 abnormal snout morphology 0.165134800366868 0.505384278708638 0.971336468947056 0.307692307692308 16.3 16 3 abnormal xiphoid process morphology 0.275059965768728 0.61117611866879 0.971336468947056 0.307692307692308 16.3 16 3 abnormal stomach morphology 0.275059965768728 0.61117611866879 0.971336468947056 0.307692307692308 16.3 16 3 small kidney 0.0938809207011752 0.368341940448223 0.968576990342093 0.306818181818182 16.3 16 3 abnormal limb morphology 0.1156359847291 0.422695829557142 0.968098680717232 0.306666666666667 16.3 16 3 organ of Corti degeneration 0.180650009001407 0.547674463608775 0.966380670636101 0.306122448979592 16.3 16 3 absent kidney 0.180650009001407 0.547674463608775 0.966380670636101 0.306122448979592 16.3 16 3 abnormal cranium morphology 0.0498224483862425 0.23800998287836 0.9658998842328 0.305970149253731 16.3 16 3 head tilt 0.231527834222833 0.558094926145319 0.96459107680159 0.305555555555556 16.3 16 3 narrow eye opening 0.231527834222833 0.558094926145319 0.96459107680159 0.305555555555556 16.3 16 3 impaired righting response 0.0897108716944081 0.367637221317694 0.963668023139579 0.305263157894737 16.3 16 3 abnormal thoracic vertebrae morphology 0.156565385601197 0.482000490944279 0.963104803955979 0.305084745762712 16.3 16 3 abnormal innervation pattern to muscle 0.307187436323469 0.655904504596249 0.960778463849805 0.304347826086957 16.3 16 3 failure of embryo implantation 0.307187436323469 0.655904504596249 0.960778463849805 0.304347826086957 16.3 16 3 abnormal nasal cavity morphology 0.307187436323469 0.655904504596249 0.960778463849805 0.304347826086957 16.3 16 3 abnormal cochlear ganglion morphology 0.307187436323469 0.655904504596249 0.960778463849805 0.304347826086957 16.3 16 3 increased susceptibility to age related obesity 0.307187436323469 0.655904504596249 0.960778463849805 0.304347826086957 16.3 16 3 abnormal corneal stroma morphology 0.307187436323469 0.655904504596249 0.960778463849805 0.304347826086957 16.3 16 3 abnormal palatal shelf fusion at midline 0.307187436323469 0.655904504596249 0.960778463849805 0.304347826086957 16.3 16 3 abnormal basicranium morphology 0.307187436323469 0.655904504596249 0.960778463849805 0.304347826086957 16.3 16 3 deafness 0.0925968406664693 0.368326074586212 0.956619249720585 0.303030303030303 16.3 16 3 decreased systemic arterial blood pressure 0.255704036322777 0.576667081008982 0.956619249720585 0.303030303030303 16.3 16 3 dilated heart atrium 0.255704036322777 0.576667081008982 0.956619249720585 0.303030303030303 16.3 16 3 head tossing 0.255704036322777 0.576667081008982 0.956619249720585 0.303030303030303 16.3 16 3 abnormal male reproductive system morphology 0.217066272474156 0.558094926145319 0.954394553791003 0.302325581395349 16.3 16 3 decreased oxygen consumption 0.217066272474156 0.558094926145319 0.954394553791003 0.302325581395349 16.3 16 3 enlarged kidney 0.186481371847627 0.555535823318528 0.953009365759376 0.30188679245283 16.3 16 3 head bobbing 0.23850341954512 0.558094926145319 0.94705305722338 0.3 16.3 16 3 abnormal circulating protein level 0.203834709950369 0.558094926145319 0.94705305722338 0.3 16.3 16 3 abnormal pericardium morphology 0.344929533636836 0.707242750382213 0.94705305722338 0.3 16.3 16 3 abnormal dopamine level 0.344929533636836 0.707242750382213 0.94705305722338 0.3 16.3 16 3 abnormal trachea morphology 0.344929533636836 0.707242750382213 0.94705305722338 0.3 16.3 16 3 abnormal postnatal subventricular zone morphology 0.344929533636836 0.707242750382213 0.94705305722338 0.3 16.3 16 3 nuclear cataracts 0.344929533636836 0.707242750382213 0.94705305722338 0.3 16.3 16 3 abnormal action potential 0.152820481189104 0.476795493068379 0.947053057223379 0.3 16.3 16 3 abnormal eye physiology 0.17588896585441 0.533891156269489 0.947053057223379 0.3 16.3 16 3 abnormal incisor morphology 0.17588896585441 0.533891156269489 0.947053057223379 0.3 16.3 16 3 abnormal hair cycle 0.283180551229392 0.624755318122495 0.947053057223379 0.3 16.3 16 3 abnormal response to new environment 0.283180551229392 0.624755318122495 0.947053057223379 0.3 16.3 16 3 abnormal lactation 0.283180551229392 0.624755318122495 0.947053057223379 0.3 16.3 16 3 abnormal pain threshold 0.283180551229392 0.624755318122495 0.947053057223379 0.3 16.3 16 3 increased insulin secretion 0.262544643761736 0.585984568288308 0.938521047698845 0.297297297297297 16.3 16 3 abnormal humerus morphology 0.262544643761736 0.585984568288308 0.938521047698845 0.297297297297297 16.3 16 3 abnormal locomotor activation 0.129843375814988 0.463726342196385 0.936645880770375 0.296703296703297 16.3 16 3 abnormal skin appearance 0.314633381283667 0.670651701750747 0.935361044171239 0.296296296296296 16.3 16 3 atelectasis 0.170183456758653 0.519106497470446 0.933714281769529 0.295774647887324 16.3 16 3 renal interstitial fibrosis 0.244428537924775 0.558094926145319 0.932703768477571 0.295454545454545 16.3 16 3 cochlear hair cell degeneration 0.244428537924775 0.558094926145319 0.932703768477571 0.295454545454545 16.3 16 3 abnormal cornea morphology 0.160616497072651 0.493860984509541 0.930864116074262 0.294871794871795 16.3 16 3 abnormal cued conditioning behavior 0.228292011929554 0.558094926145319 0.928483389434686 0.294117647058824 16.3 16 3 thin skin 0.289624354648113 0.63812274773001 0.928483389434686 0.294117647058824 16.3 16 3 increased width of hypertrophic chondrocyte zone 0.289624354648113 0.63812274773001 0.928483389434686 0.294117647058824 16.3 16 3 abnormal cranial suture morphology 0.390038765994625 0.756920913731148 0.928483389434686 0.294117647058824 16.3 16 3 abnormal tarsal bone morphology 0.390038765994625 0.756920913731148 0.928483389434686 0.294117647058824 16.3 16 3 decreased growth hormone level 0.390038765994625 0.756920913731148 0.928483389434686 0.294117647058824 16.3 16 3 pancytopenia 0.390038765994625 0.756920913731148 0.928483389434686 0.294117647058824 16.3 16 3 increased circulating magnesium level 0.390038765994625 0.756920913731148 0.928483389434686 0.294117647058824 16.3 16 3 common atrium 0.390038765994625 0.756920913731148 0.928483389434686 0.294117647058824 16.3 16 3 abnormal enzyme/coenzyme level 0.213765670102116 0.558094926145319 0.925281722574566 0.293103448275862 16.3 16 3 abnormal cardiovascular system morphology 0.249508111427022 0.565771583568567 0.920746027856064 0.291666666666667 16.3 16 3 abnormal digestive system morphology 0.35095883004346 0.713535014085089 0.920746027856064 0.291666666666667 16.3 16 3 abnormal foregut morphology 0.35095883004346 0.713535014085089 0.920746027856064 0.291666666666667 16.3 16 3 apnea 0.35095883004346 0.713535014085089 0.920746027856064 0.291666666666667 16.3 16 3 decreased fatty acid level 0.35095883004346 0.713535014085089 0.920746027856064 0.291666666666667 16.3 16 3 abnormal heart left ventricle morphology 0.188543255466333 0.558094926145319 0.920746027856063 0.291666666666667 16.3 16 3 impaired branching involved in ureteric bud morphogenesis 0.29482660286853 0.639526990838453 0.91382312539098 0.289473684210526 16.3 16 3 albuminuria 0.27300344923059 0.607420465081477 0.911977018066958 0.288888888888889 16.3 16 3 abnormal female meiosis 0.253896286887399 0.573369962444308 0.910627939637865 0.288461538461538 16.3 16 3 decreased body temperature 0.253896286887399 0.573369962444308 0.910627939637865 0.288461538461538 16.3 16 3 abnormal spatial learning 0.0921282345742917 0.368326074586212 0.910255494672778 0.288343558282209 16.3 16 3 abnormal skin morphology 0.221666759647886 0.558094926145319 0.908788287234556 0.287878787878788 16.3 16 3 short limbs 0.183708475296766 0.549248596515271 0.907138943700555 0.28735632183908 16.3 16 3 decreased exploration in new environment 0.198203411779622 0.558094926145319 0.901955292593695 0.285714285714286 16.3 16 3 increased food intake 0.198203411779622 0.558094926145319 0.901955292593695 0.285714285714286 16.3 16 3 abnormal optic nerve morphology 0.299082009567604 0.641350429999495 0.901955292593695 0.285714285714286 16.3 16 3 abnormal stria vascularis morphology 0.35520777760701 0.720700935397584 0.901955292593695 0.285714285714286 16.3 16 3 abnormal jaw morphology 0.35520777760701 0.720700935397584 0.901955292593695 0.285714285714286 16.3 16 3 increased circulating luteinizing hormone level 0.35520777760701 0.720700935397584 0.901955292593695 0.285714285714286 16.3 16 3 abnormal ovulation 0.35520777760701 0.720700935397584 0.901955292593695 0.285714285714286 16.3 16 3 corneal vascularization 0.35520777760701 0.720700935397584 0.901955292593695 0.285714285714286 16.3 16 3 abnormal stapes morphology 0.393382746233199 0.756920913731148 0.901955292593695 0.285714285714286 16.3 16 3 cardiac hypertrophy 0.175672570092192 0.533885788765213 0.901955292593695 0.285714285714286 16.3 16 3 abnormal epidermis stratum corneum morphology 0.277051352397269 0.614777198116152 0.901955292593695 0.285714285714286 16.3 16 3 abnormal craniofacial development 0.277051352397269 0.614777198116152 0.901955292593695 0.285714285714286 16.3 16 3 increased fluid intake 0.277051352397269 0.614777198116152 0.901955292593695 0.285714285714286 16.3 16 3 abnormal forelimb morphology 0.302597849736532 0.648330879603465 0.892151430717676 0.282608695652174 16.3 16 3 abnormal circulating hormone level 0.328100693078301 0.694300701005763 0.890391763201468 0.282051282051282 16.3 16 3 abnormal long term potentiation 0.358263899679364 0.72660534076838 0.887862241146918 0.28125 16.3 16 3 abnormal blood homeostasis 0.184459662745007 0.551163256550397 0.886131515530648 0.280701754385965 16.3 16 3 abnormal circulating amino acid level 0.283475164383436 0.625128077485635 0.886131515530648 0.280701754385965 16.3 16 3 mandible hypoplasia 0.395282853749062 0.756920913731148 0.883916186741821 0.28 16.3 16 3 abnormal feces composition 0.395282853749062 0.756920913731148 0.883916186741821 0.28 16.3 16 3 abnormal vertebrae development 0.395282853749062 0.756920913731148 0.883916186741821 0.28 16.3 16 3 abnormal stomach mucosa morphology 0.395282853749062 0.756920913731148 0.883916186741821 0.28 16.3 16 3 abnormal axon guidance 0.330830036829584 0.699778670589787 0.880979588114772 0.27906976744186 16.3 16 3 cochlear outer hair cell degeneration 0.268832093529071 0.598674872563621 0.876900978910537 0.277777777777778 16.3 16 3 heart right ventricle hypertrophy 0.360481047528483 0.730208962318487 0.876900978910537 0.277777777777778 16.3 16 3 reduced long term depression 0.360481047528483 0.730208962318487 0.876900978910537 0.277777777777778 16.3 16 3 abnormal limb bone morphology 0.360481047528483 0.730208962318487 0.876900978910537 0.277777777777778 16.3 16 3 lowered ear position 0.443647086666441 0.760011336955118 0.876900978910537 0.277777777777778 16.3 16 3 abnormal mitral valve morphology 0.443647086666441 0.760011336955118 0.876900978910537 0.277777777777778 16.3 16 3 abnormal stomach glandular epithelium morphology 0.443647086666441 0.760011336955118 0.876900978910537 0.277777777777778 16.3 16 3 absent spleen 0.443647086666441 0.760011336955118 0.876900978910537 0.277777777777778 16.3 16 3 thick dermal layer 0.443647086666441 0.760011336955118 0.876900978910537 0.277777777777778 16.3 16 3 acidosis 0.443647086666441 0.760011336955118 0.876900978910537 0.277777777777778 16.3 16 3 abnormal metacarpal bone morphology 0.443647086666441 0.760011336955118 0.876900978910537 0.277777777777778 16.3 16 3 decreased activity of thyroid 0.443647086666441 0.760011336955118 0.876900978910537 0.277777777777778 16.3 16 3 absent ureter 0.443647086666441 0.760011336955118 0.876900978910537 0.277777777777778 16.3 16 3 increased susceptibility to autoimmune disorder 0.443647086666441 0.760011336955118 0.876900978910537 0.277777777777778 16.3 16 3 jerky movement 0.443647086666441 0.760011336955118 0.876900978910537 0.277777777777778 16.3 16 3 small thoracic cage 0.443647086666441 0.760011336955118 0.876900978910537 0.277777777777778 16.3 16 3 atrioventricular block 0.443647086666441 0.760011336955118 0.876900978910537 0.277777777777778 16.3 16 3 cochlear ganglion degeneration 0.31003116220489 0.661692420407263 0.870853385952533 0.275862068965517 16.3 16 3 abnormal middle ear morphology 0.39629450109658 0.756920913731148 0.870853385952533 0.275862068965517 16.3 16 3 decreased retinal photoreceptor cell number 0.39629450109658 0.756920913731148 0.870853385952533 0.275862068965517 16.3 16 3 absent long term depression 0.39629450109658 0.756920913731148 0.870853385952533 0.275862068965517 16.3 16 3 abnormal social investigation 0.272642427206172 0.606888624317988 0.868131969121431 0.275 16.3 16 3 abnormal female reproductive system morphology 0.362085865797784 0.732862970847834 0.868131969121431 0.275 16.3 16 3 increased susceptibility to weight loss 0.362085865797784 0.732862970847834 0.868131969121431 0.275 16.3 16 3 increased kidney weight 0.334747591363346 0.70723314288296 0.866584496805707 0.274509803921569 16.3 16 3 abnormal nervous system electrophysiology 0.274233897374509 0.609885399838259 0.864373822068958 0.273809523809524 16.3 16 3 abnormal oogenesis 0.441680536392908 0.760011336955118 0.860957324748527 0.272727272727273 16.3 16 3 abnormal channel response 0.441680536392908 0.760011336955118 0.860957324748527 0.272727272727273 16.3 16 3 abnormal female reproductive system physiology 0.441680536392908 0.760011336955118 0.860957324748527 0.272727272727273 16.3 16 3 abnormal temporal bone morphology 0.441680536392908 0.760011336955118 0.860957324748527 0.272727272727273 16.3 16 3 failure of palatal shelf elevation 0.441680536392908 0.760011336955118 0.860957324748527 0.272727272727273 16.3 16 3 pulmonary vascular congestion 0.441680536392908 0.760011336955118 0.860957324748527 0.272727272727273 16.3 16 3 increased circulating creatine kinase level 0.441680536392908 0.760011336955118 0.860957324748527 0.272727272727273 16.3 16 3 impaired swimming 0.313219587123173 0.668210740110543 0.860957324748527 0.272727272727273 16.3 16 3 abnormal tooth development 0.396723848438084 0.756920913731148 0.860957324748527 0.272727272727273 16.3 16 3 dehydration 0.314444329688082 0.670536022373857 0.85685752796401 0.271428571428571 16.3 16 3 abnormal urine homeostasis 0.278025007572911 0.6166626895565 0.854978454437773 0.270833333333333 16.3 16 3 curly tail 0.364021468214953 0.73588248856944 0.854978454437773 0.270833333333333 16.3 16 3 abnormal hair shaft morphology 0.364021468214953 0.73588248856944 0.854978454437773 0.270833333333333 16.3 16 3 absent corpus luteum 0.36453491406501 0.736023213260319 0.849919410328674 0.269230769230769 16.3 16 3 abnormal skin condition 0.36453491406501 0.736023213260319 0.849919410328674 0.269230769230769 16.3 16 3 abnormal ureter morphology 0.439575496689184 0.760011336955118 0.849919410328674 0.269230769230769 16.3 16 3 abnormal eye development 0.364827379193862 0.736246448128205 0.845583086806589 0.267857142857143 16.3 16 3 abnormal kidney development 0.364941455494302 0.736246448128205 0.841824939754115 0.266666666666667 16.3 16 3 increased circulating corticosterone level 0.396040471532813 0.756920913731148 0.841824939754115 0.266666666666667 16.3 16 3 abnormal metabolism 0.396040471532813 0.756920913731148 0.841824939754115 0.266666666666667 16.3 16 3 abnormal heart tube morphology 0.43742684650283 0.760011336955118 0.841824939754115 0.266666666666667 16.3 16 3 emphysema 0.43742684650283 0.760011336955118 0.841824939754115 0.266666666666667 16.3 16 3 abnormal synaptic transmission 0.43742684650283 0.760011336955118 0.841824939754115 0.266666666666667 16.3 16 3 abnormal vertebrae morphology 0.29967608465089 0.642347488642042 0.83989414860789 0.26605504587156 16.3 16 3 decreased urine osmolality 0.395427343371339 0.756920913731148 0.837529914551288 0.26530612244898 16.3 16 3 impaired synaptic plasticity 0.435279666202475 0.760011336955118 0.835635050491217 0.264705882352941 16.3 16 3 abnormal digit morphology 0.364506806776062 0.736023213260319 0.83305592996501 0.263888888888889 16.3 16 3 abnormal reproductive system physiology 0.433156356377096 0.760011336955118 0.830748295809982 0.263157894736842 16.3 16 3 kyphoscoliosis 0.495992345051782 0.837313171575371 0.830748295809982 0.263157894736842 16.3 16 3 decreased chemically-elicited antinociception 0.495992345051782 0.837313171575371 0.830748295809982 0.263157894736842 16.3 16 3 abnormal ear morphology 0.495992345051782 0.837313171575371 0.830748295809982 0.263157894736842 16.3 16 3 abnormal neurotransmitter level 0.495992345051782 0.837313171575371 0.830748295809982 0.263157894736842 16.3 16 3 abnormal metatarsal bone morphology 0.495992345051782 0.837313171575371 0.830748295809982 0.263157894736842 16.3 16 3 increased liver adenoma incidence 0.495992345051782 0.837313171575371 0.830748295809982 0.263157894736842 16.3 16 3 abnormal photoreceptor inner segment morphology 0.495992345051782 0.837313171575371 0.830748295809982 0.263157894736842 16.3 16 3 increased circulating VLDL cholesterol level 0.495992345051782 0.837313171575371 0.830748295809982 0.263157894736842 16.3 16 3 abnormal behavioral response to xenobiotic 0.495992345051782 0.837313171575371 0.830748295809982 0.263157894736842 16.3 16 3 abnormal maternal nurturing 0.392997076537264 0.756920913731148 0.828024530905687 0.262295081967213 16.3 16 3 hydronephrosis 0.36330150383618 0.73502439267385 0.82679235154422 0.261904761904762 16.3 16 3 abnormal reproductive system morphology 0.431068102781151 0.760011336955118 0.82679235154422 0.261904761904762 16.3 16 3 abnormal blood vessel physiology 0.489148689358592 0.828571579693223 0.823524397585547 0.260869565217391 16.3 16 3 abnormal carpal bone morphology 0.489148689358592 0.828571579693223 0.823524397585547 0.260869565217391 16.3 16 3 bidirectional circling 0.489148689358592 0.828571579693223 0.823524397585547 0.260869565217391 16.3 16 3 abnormal cardiovascular development 0.489148689358592 0.828571579693223 0.823524397585547 0.260869565217391 16.3 16 3 abnormal crista ampullaris morphology 0.489148689358592 0.828571579693223 0.823524397585547 0.260869565217391 16.3 16 3 decreased epididymis weight 0.489148689358592 0.828571579693223 0.823524397585547 0.260869565217391 16.3 16 3 abnormal lens development 0.489148689358592 0.828571579693223 0.823524397585547 0.260869565217391 16.3 16 3 abnormal hindlimb morphology 0.427014831997864 0.760011336955118 0.820779316260262 0.26 16.3 16 3 abnormal cochlea morphology 0.425052286718742 0.759567214951775 0.818440913649834 0.259259259259259 16.3 16 3 abnormal mandible morphology 0.425052286718742 0.759567214951775 0.818440913649834 0.259259259259259 16.3 16 3 wrinkled skin 0.483305237081115 0.820909373328285 0.818440913649834 0.259259259259259 16.3 16 3 abnormal type II pneumocyte morphology 0.483305237081115 0.820909373328285 0.818440913649834 0.259259259259259 16.3 16 3 abnormal mitochondrial ATP synthesis coupled electron transport 0.478172330624772 0.812745932647161 0.81466929653624 0.258064516129032 16.3 16 3 impaired adaptive thermogenesis 0.473570843176706 0.805199912783361 0.811759763334325 0.257142857142857 16.3 16 3 abnormal excitatory postsynaptic potential 0.412417128372576 0.756920913731148 0.808459926898007 0.25609756097561 16.3 16 3 abnormal innervation 0.461938889996559 0.78569093255825 0.806002601892238 0.25531914893617 16.3 16 3 abnormal thrombosis 0.458579940635988 0.780511530846404 0.804685604176728 0.254901960784314 16.3 16 3 abnormal colon morphology 0.452414652554105 0.770281620963954 0.802587336629983 0.254237288135593 16.3 16 3 abnormal hair follicle morphology 0.449560358112895 0.76568393755962 0.801738037861062 0.253968253968254 16.3 16 3 abnormal femur morphology 0.446833904267801 0.76130091566175 0.800990147900371 0.253731343283582 16.3 16 3 decreased food intake 0.43929047888058 0.760011336955118 0.799200892171628 0.253164556962025 16.3 16 3 short mandible 0.485609648355147 0.82454197971565 0.789210881019483 0.25 16.3 16 3 short radius 0.511267441726114 0.859890305134353 0.789210881019483 0.25 16.3 16 3 myoclonus 0.52600439023915 0.870498448186197 0.789210881019483 0.25 16.3 16 3 increased stereotypic behavior 0.535211975796969 0.870498448186197 0.789210881019483 0.25 16.3 16 3 abnormal startle reflex 0.535211975796969 0.870498448186197 0.789210881019483 0.25 16.3 16 3 prolonged QT interval 0.535211975796969 0.870498448186197 0.789210881019483 0.25 16.3 16 3 abnormal gametogenesis 0.499623050963038 0.843156268161844 0.789210881019483 0.25 16.3 16 3 increased dopamine level 0.518141807606574 0.865018621759298 0.789210881019483 0.25 16.3 16 3 abnormal serotonin level 0.518141807606574 0.865018621759298 0.789210881019483 0.25 16.3 16 3 abnormal basioccipital bone morphology 0.546346615523431 0.870498448186197 0.789210881019483 0.25 16.3 16 3 decreased skin tensile strength 0.546346615523431 0.870498448186197 0.789210881019483 0.25 16.3 16 3 abnormal incus morphology 0.546346615523431 0.870498448186197 0.789210881019483 0.25 16.3 16 3 abnormal circulating cytokine level 0.546346615523431 0.870498448186197 0.789210881019483 0.25 16.3 16 3 abnormal eye electrophysiology 0.459551013615233 0.781896816941103 0.782688477044115 0.247933884297521 16.3 16 3 polyuria 0.493276535701317 0.835279361849576 0.778961389058191 0.246753246753247 16.3 16 3 abnormal autopod morphology 0.53313506195517 0.870498448186197 0.771672861441272 0.244444444444444 16.3 16 3 impaired fertilization 0.528226885784382 0.870498448186197 0.76666199870464 0.242857142857143 16.3 16 3 diarrhea 0.556995554540491 0.870498448186197 0.765295399776468 0.242424242424242 16.3 16 3 small ovary 0.52987954990729 0.870498448186197 0.763192939886972 0.241758241758242 16.3 16 3 increased susceptibility to pharmacologically induced seizures 0.548423927820146 0.870498448186197 0.756327094310338 0.239583333333333 16.3 16 3 abnormal anxiety-related response 0.594147824676629 0.915134807357965 0.751629410494746 0.238095238095238 16.3 16 3 hypoalgesia 0.594147824676629 0.915134807357965 0.751629410494746 0.238095238095238 16.3 16 3 increased keratinocyte proliferation 0.594147824676629 0.915134807357965 0.751629410494746 0.238095238095238 16.3 16 3 increased grooming behavior 0.583739932505778 0.899939933131777 0.747673466228984 0.236842105263158 16.3 16 3 decreased threshold for auditory brainstem response 0.583739932505778 0.899939933131777 0.747673466228984 0.236842105263158 16.3 16 3 abnormal skin physiology 0.594446597106035 0.915311612690351 0.742786711547749 0.235294117647059 16.3 16 3 delayed eyelid opening 0.606794940546131 0.92456077509951 0.736596822284851 0.233333333333333 16.3 16 3 abnormal blood circulation 0.607259469534257 0.92456077509951 0.73414965676231 0.232558139534884 16.3 16 3 enhanced long term potentiation 0.609746176170114 0.925407939733471 0.732838675232377 0.232142857142857 16.3 16 3 small lens 0.618047178106577 0.935722675313517 0.728502351710292 0.230769230769231 16.3 16 3 abnormal iris morphology 0.618047178106577 0.935722675313517 0.728502351710292 0.230769230769231 16.3 16 3 decreased kidney weight 0.618573046705945 0.93623392374873 0.728502351710292 0.230769230769231 16.3 16 3 small seminal vesicle 0.621347506475287 0.939861308821695 0.728502351710292 0.230769230769231 16.3 16 3 abnormal tectorial membrane morphology 0.621347506475287 0.939861308821695 0.728502351710292 0.230769230769231 16.3 16 3 abnormal phalanx morphology 0.628240587920242 0.949999065320123 0.723443307601193 0.229166666666667 16.3 16 3 impaired behavioral response to xenobiotic 0.630261635307317 0.952765613993893 0.721564234074956 0.228571428571429 16.3 16 3 decreased cardiac output 0.638991144760076 0.961288462407432 0.717464437290439 0.227272727272727 16.3 16 3 parakeratosis 0.638991144760076 0.961288462407432 0.717464437290439 0.227272727272727 16.3 16 3 abnormal podocyte morphology 0.64430986843986 0.963515185160158 0.71283563446921 0.225806451612903 16.3 16 3 abnormal intestine physiology 0.64430986843986 0.963515185160158 0.71283563446921 0.225806451612903 16.3 16 3 abnormal epidermis stratum granulosum morphology 0.664259976330518 0.963515185160158 0.701520783128429 0.222222222222222 16.3 16 3 abnormal palate morphology 0.660788154873623 0.963515185160158 0.701520783128429 0.222222222222222 16.3 16 3 abnormal ovarian follicle morphology 0.669140719058574 0.965760103660112 0.701520783128429 0.222222222222222 16.3 16 3 polyphagia 0.67456819360208 0.967067748723788 0.701520783128429 0.222222222222222 16.3 16 3 abnormal inhibitory postsynaptic currents 0.694743681363257 0.988658413839304 0.696362542076014 0.220588235294118 16.3 16 3 syndactyly 0.690045526481254 0.983443570357137 0.695575691745985 0.220338983050847 16.3 16 3 abnormal digestive system physiology 0.685659168000241 0.979091377956716 0.694505575297145 0.22 16.3 16 3 polydipsia 0.67963692547318 0.971328268954057 0.690559520892048 0.21875 16.3 16 3 hypotension 0.680614049038266 0.972166205559969 0.686270331321289 0.217391304347826 16.3 16 3 abnormal sacral vertebrae morphology 0.680614049038266 0.972166205559969 0.686270331321289 0.217391304347826 16.3 16 3 decreased circulating progesterone level 0.697547363410297 0.992080655507784 0.676466469445271 0.214285714285714 16.3 16 3 prolonged QRS complex duration 0.697547363410297 0.992080655507784 0.676466469445271 0.214285714285714 16.3 16 3 increased systemic arterial blood pressure 0.724917458980376 1 0.671668834910198 0.212765957446809 16.3 16 3 absent vibrissae 0.712655756108904 1 0.66963347480441 0.212121212121212 16.3 16 3 abnormal CNS synaptic transmission 0.78016741017693 1 0.66963347480441 0.212121212121212 16.3 16 3 abnormal intestinal mucosa morphology 0.738834164218038 1 0.660734691086079 0.209302325581395 16.3 16 3 decreased ovulation rate 0.718877752522818 1 0.657675734182902 0.208333333333333 16.3 16 3 abnormal lens fiber morphology 0.754273723216701 1 0.647557645964704 0.205128205128205 16.3 16 3 abnormal estrous cycle 0.762715353302731 1 0.631368704815586 0.2 16.3 16 3 short ulna 0.803941482383697 1 0.615969468112767 0.195121951219512 16.3 16 3 absent mature ovarian follicles 0.79113266966982 1 0.61100197240218 0.193548387096774 16.3 16 3 abnormal body temperature homeostasis 0.79113266966982 1 0.61100197240218 0.193548387096774 16.3 16 3 abnormal epidermal layer morphology 0.878196092072538 1 0.594767620478451 0.188405797101449 16.3 16 3 abnormal middle ear ossicle morphology 0.840019501388391 1 0.573971549832351 0.181818181818182 16.3 16 3 decreased oocyte number 0.881373661789571 1 0.568231834334028 0.18 16.3 16 3 abnormal cartilage development 0.879892163918845 1 0.561216626502743 0.177777777777778 16.3 16 3 decreased pancreatic beta cell number 0.86074455701955 1 0.557090033660811 0.176470588235294 16.3 16 3 impaired ovarian folliculogenesis 0.879059639737915 1 0.552447616713638 0.175 16.3 16 3 aphagia 0.861127209701508 1 0.544283366220333 0.172413793103448 16.3 16 3 abnormal tibia morphology 0.907626099922814 1 0.537335067928159 0.170212765957447 16.3 16 3 abnormal systemic arterial blood pressure 0.895542444717811 1 0.526140587346322 0.166666666666667 16.3 16 3 abnormal epidermis stratum basale morphology 0.92613927338393 1 0.478309624860293 0.151515151515152 16.3 16 3 abnormal reflex 0.955435789902255 1 0.438450489455268 0.138888888888889 16.3 16 3 vasculitis 9.68452477103207e-05 0.0011152896003677 1.31642198702629 1 17.3 17 3 elevated level of mitotic sister chromatid exchange 0.00120499869822733 0.00981156877852859 1.31642198702629 1 17.3 17 3 accumulation of giant lysosomes in kidney/renal tubule cells 0.00120499869822733 0.00981156877852859 1.31642198702629 1 17.3 17 3 craniofacial phenotype 0.00120499869822733 0.00981156877852859 1.31642198702629 1 17.3 17 3 abnormal cerebellum deep nucleus morphology 0.00120499869822733 0.00981156877852859 1.31642198702629 1 17.3 17 3 abnormal foramen magnum morphology 0.00120499869822733 0.00981156877852859 1.31642198702629 1 17.3 17 3 abnormal umbilical vein topology 0.00120499869822733 0.00981156877852859 1.31642198702629 1 17.3 17 3 increased brain apoptosis 0.00120499869822733 0.00981156877852859 1.31642198702629 1 17.3 17 3 decreased vascular endothelial cell proliferation 0.00120499869822733 0.00981156877852859 1.31642198702629 1 17.3 17 3 decreased B-1 B cell number 5.74919333268273e-15 4.46909950470259e-13 1.31642198702629 1 17.3 17 3 abnormal thymocyte activation 5.01697987637678e-08 1.29323704067225e-06 1.31642198702629 1 17.3 17 3 abnormal dendritic cell morphology 3.35710125446333e-06 5.83971284648779e-05 1.31642198702629 1 17.3 17 3 abnormal spleen periarteriolar lymphoid sheath morphology 7.7806919239185e-06 0.00012096544475467 1.31642198702629 1 17.3 17 3 abnormal B cell proliferation 4.17902678911578e-05 0.000537226312037494 1.31642198702629 1 17.3 17 3 decreased red blood cell distribution width 4.17902678911578e-05 0.000537226312037494 1.31642198702629 1 17.3 17 3 absent CD4-positive, alpha beta T cells 0.000224421573682802 0.00230681266337178 1.31642198702629 1 17.3 17 3 decreased transitional stage T2 B cell number 0.000224421573682802 0.00230681266337178 1.31642198702629 1 17.3 17 3 abnormal inferior vena cava valve morphology 0.000224421573682802 0.00230681266337178 1.31642198702629 1 17.3 17 3 decreased macrophage cytokine production 0.000224421573682802 0.00230681266337178 1.31642198702629 1 17.3 17 3 decreased macrophage apoptosis 0.000224421573682802 0.00230681266337178 1.31642198702629 1 17.3 17 3 decreased transitional stage T1 B cell number 0.000520036736229315 0.00485400143103347 1.31642198702629 1 17.3 17 3 cellular necrosis 0.00279204405299743 0.0193707878742637 1.31642198702629 1 17.3 17 3 abnormal circulating alanine transaminase level 0.00279204405299743 0.0193707878742637 1.31642198702629 1 17.3 17 3 decreased activated T cell number 0.00279204405299743 0.0193707878742637 1.31642198702629 1 17.3 17 3 abnormal tumor incidence 0.00279204405299743 0.0193707878742637 1.31642198702629 1 17.3 17 3 abnormal hypersensitivity reaction 0.00279204405299743 0.0193707878742637 1.31642198702629 1 17.3 17 3 decreased mortality induced by ionizing radiation 0.00279204405299743 0.0193707878742637 1.31642198702629 1 17.3 17 3 heart hemorrhage 0.00279204405299743 0.0193707878742637 1.31642198702629 1 17.3 17 3 decreased DN2 thymocyte number 0.00279204405299743 0.0193707878742637 1.31642198702629 1 17.3 17 3 decreased brain cholesterol level 0.00279204405299743 0.0193707878742637 1.31642198702629 1 17.3 17 3 decreased T-helper 17 cell number 0.00279204405299743 0.0193707878742637 1.31642198702629 1 17.3 17 3 delayed brain development 0.00646905869182094 0.0384970897031211 1.31642198702629 1 17.3 17 3 abnormal gustatory system physiology 0.00646905869182094 0.0384970897031211 1.31642198702629 1 17.3 17 3 decreased posterior semicircular canal size 0.00646905869182094 0.0384970897031211 1.31642198702629 1 17.3 17 3 extremity edema 0.00646905869182094 0.0384970897031211 1.31642198702629 1 17.3 17 3 enlarged pancreas 0.00646905869182094 0.0384970897031211 1.31642198702629 1 17.3 17 3 rheumatoid arthritis 0.00646905869182094 0.0384970897031211 1.31642198702629 1 17.3 17 3 abnormal leukocyte tethering or rolling 0.00646905869182094 0.0384970897031211 1.31642198702629 1 17.3 17 3 abnormal immature B cell morphology 0.00646905869182094 0.0384970897031211 1.31642198702629 1 17.3 17 3 osteomyelitis 0.00646905869182094 0.0384970897031211 1.31642198702629 1 17.3 17 3 increased transitional stage T1 B cell number 0.00646905869182094 0.0384970897031211 1.31642198702629 1 17.3 17 3 cerebral arteriovenous malformation 0.00646905869182094 0.0384970897031211 1.31642198702629 1 17.3 17 3 absent third pharyngeal arch 0.00646905869182094 0.0384970897031211 1.31642198702629 1 17.3 17 3 decreased macrophage nitric oxide production 0.00646905869182094 0.0384970897031211 1.31642198702629 1 17.3 17 3 delayed limb development 0.00646905869182094 0.0384970897031211 1.31642198702629 1 17.3 17 3 thymus cortex atrophy 0.00646905869182094 0.0384970897031211 1.31642198702629 1 17.3 17 3 increased bone trabecular spacing 0.00646905869182094 0.0384970897031211 1.31642198702629 1 17.3 17 3 abnormal vertebral artery origin 0.00646905869182094 0.0384970897031211 1.31642198702629 1 17.3 17 3 additional anastomosis between intracranial vertebral arteries 0.00646905869182094 0.0384970897031211 1.31642198702629 1 17.3 17 3 increased cardiac cell glucose uptake 0.00646905869182094 0.0384970897031211 1.31642198702629 1 17.3 17 3 abnormal pineal gland morphology 0.014987978262833 0.0737538989689357 1.31642198702629 1 17.3 17 3 decreased sensitivity to skin irradiation 0.014987978262833 0.0737538989689357 1.31642198702629 1 17.3 17 3 skin hyperplasia 0.014987978262833 0.0737538989689357 1.31642198702629 1 17.3 17 3 sinus inflammation 0.014987978262833 0.0737538989689357 1.31642198702629 1 17.3 17 3 abnormal respiratory sounds 0.014987978262833 0.0737538989689357 1.31642198702629 1 17.3 17 3 increased hepatic hemangioma incidence 0.014987978262833 0.0737538989689357 1.31642198702629 1 17.3 17 3 abnormal sebaceous gland physiology 0.014987978262833 0.0737538989689357 1.31642198702629 1 17.3 17 3 decreased lysosomal enzyme secretion 0.014987978262833 0.0737538989689357 1.31642198702629 1 17.3 17 3 increased lysosomal enzyme secretion 0.014987978262833 0.0737538989689357 1.31642198702629 1 17.3 17 3 enhanced NMDA-mediated synaptic currents 0.014987978262833 0.0737538989689357 1.31642198702629 1 17.3 17 3 abnormal response to vitamins 0.014987978262833 0.0737538989689357 1.31642198702629 1 17.3 17 3 increased heart right ventricle weight 0.014987978262833 0.0737538989689357 1.31642198702629 1 17.3 17 3 abnormal T cell selection 0.014987978262833 0.0737538989689357 1.31642198702629 1 17.3 17 3 abnormal tail pigmentation 0.014987978262833 0.0737538989689357 1.31642198702629 1 17.3 17 3 corneal deposits 0.014987978262833 0.0737538989689357 1.31642198702629 1 17.3 17 3 increased placenta apoptosis 0.014987978262833 0.0737538989689357 1.31642198702629 1 17.3 17 3 abnormal mismatch repair 0.014987978262833 0.0737538989689357 1.31642198702629 1 17.3 17 3 decreased DN3 thymocyte number 0.014987978262833 0.0737538989689357 1.31642198702629 1 17.3 17 3 increased response to stress-induced hyperthermia 0.014987978262833 0.0737538989689357 1.31642198702629 1 17.3 17 3 increased T follicular helper cell number 0.014987978262833 0.0737538989689357 1.31642198702629 1 17.3 17 3 decreased lung tumor incidence 0.014987978262833 0.0737538989689357 1.31642198702629 1 17.3 17 3 aorta hypoplasia 0.014987978262833 0.0737538989689357 1.31642198702629 1 17.3 17 3 increased CD4-positive, alpha-beta memory T cell number 0.014987978262833 0.0737538989689357 1.31642198702629 1 17.3 17 3 abnormal lung alveolus development 0.014987978262833 0.0737538989689357 1.31642198702629 1 17.3 17 3 increased macrophage cytokine production 0.014987978262833 0.0737538989689357 1.31642198702629 1 17.3 17 3 decreased small intestinal villus height 0.014987978262833 0.0737538989689357 1.31642198702629 1 17.3 17 3 decreased fibroblast chemotaxis 0.014987978262833 0.0737538989689357 1.31642198702629 1 17.3 17 3 decreased B cell proliferation 2.53069788042349e-24 5.72282816141221e-22 1.2664312786582 0.962025316455696 17.3 17 3 abnormal Peyer's patch follicle morphology 6.66507978755495e-06 0.000107309941563385 1.2432874321915 0.944444444444444 17.3 17 3 increased regulatory T cell number 1.46247970977345e-05 0.000214626447083272 1.23898539955415 0.941176470588235 17.3 17 3 abnormal T cell subpopulation ratio 8.62850843800352e-10 2.92019248156922e-08 1.23663883629742 0.939393939393939 17.3 17 3 abnormal level of surface class II molecules 3.19873565339461e-05 0.000428940966998334 1.23414561283715 0.9375 17.3 17 3 delayed intramembranous bone ossification 6.97109612962908e-05 0.000841776777788948 1.22866052122454 0.933333333333333 17.3 17 3 heterochrony 6.97109612962908e-05 0.000841776777788948 1.22866052122454 0.933333333333333 17.3 17 3 increased hemangioma incidence 0.000151305530252045 0.00163996734859242 1.22239184509584 0.928571428571429 17.3 17 3 increased B-1 B cell number 0.000151305530252045 0.00163996734859242 1.22239184509584 0.928571428571429 17.3 17 3 abnormal lysosome morphology 1.25920719607295e-09 4.20439986608249e-08 1.2067201547741 0.916666666666667 17.3 17 3 increased hemangiosarcoma incidence 8.89860952409414e-07 1.86010850346085e-05 1.2067201547741 0.916666666666667 17.3 17 3 abnormal thymus involution 0.000702450025721113 0.00610959594049394 1.2067201547741 0.916666666666667 17.3 17 3 increased papilloma incidence 0.000702450025721113 0.00610959594049394 1.2067201547741 0.916666666666667 17.3 17 3 increased fibrosarcoma incidence 0.000702450025721113 0.00610959594049394 1.2067201547741 0.916666666666667 17.3 17 3 abnormal pulmonary valve cusp morphology 0.000702450025721113 0.00610959594049394 1.2067201547741 0.916666666666667 17.3 17 3 increased B cell proliferation 6.05250152217526e-15 4.63249154966491e-13 1.20486080168508 0.915254237288136 17.3 17 3 increased activated T cell number 4.0273195381814e-06 6.83819614418172e-05 1.19674726093299 0.909090909090909 17.3 17 3 abnormal sphenoid bone morphology 0.00150018483340762 0.0115354243372534 1.19674726093299 0.909090909090909 17.3 17 3 abnormal thrombopoiesis 0.00150018483340762 0.0115354243372534 1.19674726093299 0.909090909090909 17.3 17 3 delayed hepatic development 0.00150018483340762 0.0115354243372534 1.19674726093299 0.909090909090909 17.3 17 3 impaired myelopoiesis 0.00150018483340762 0.0115354243372534 1.19674726093299 0.909090909090909 17.3 17 3 loss of cortex neurons 0.00150018483340762 0.0115354243372534 1.19674726093299 0.909090909090909 17.3 17 3 abnormal dorsal-ventral polarity of the somites 0.00150018483340762 0.0115354243372534 1.19674726093299 0.909090909090909 17.3 17 3 reduced sympathetic cervical ganglion size 0.00150018483340762 0.0115354243372534 1.19674726093299 0.909090909090909 17.3 17 3 increased fibroblast apoptosis 2.55274631814179e-08 6.97797413887659e-07 1.19300742574257 0.90625 17.3 17 3 abnormal T cell proliferation 5.37856660066333e-08 1.35829283443148e-06 1.18902631086245 0.903225806451613 17.3 17 3 increased B cell derived lymphoma incidence 5.06802238015091e-12 2.43126884669289e-10 1.18477978832366 0.9 17.3 17 3 decreased myocardial infarction size 1.79328269036862e-05 0.000257106091774752 1.18477978832366 0.9 17.3 17 3 absent ductus venosus valve 1.79328269036862e-05 0.000257106091774752 1.18477978832366 0.9 17.3 17 3 abnormal tibialis anterior morphology 0.00318057319914791 0.0213829076564336 1.18477978832366 0.9 17.3 17 3 abnormal gas homeostasis 0.00318057319914791 0.0213829076564336 1.18477978832366 0.9 17.3 17 3 absent inguinal lymph nodes 0.00318057319914791 0.0213829076564336 1.18477978832366 0.9 17.3 17 3 acanthocytosis 0.00318057319914791 0.0213829076564336 1.18477978832366 0.9 17.3 17 3 thick aortic valve cusps 0.00318057319914791 0.0213829076564336 1.18477978832366 0.9 17.3 17 3 lethality during fetal growth through weaning, complete penetrance 0.00318057319914791 0.0213829076564336 1.18477978832366 0.9 17.3 17 3 abnormal dendritic cell physiology 5.53886596005603e-24 1.19808078918603e-21 1.1810888855563 0.897196261682243 17.3 17 3 abnormal cell cycle 1.71531629902749e-25 4.7409436598121e-23 1.17905621446702 0.895652173913044 17.3 17 3 abnormal blastocyst morphology 3.75736016059811e-05 0.000489342062800408 1.17785125154984 0.894736842105263 17.3 17 3 increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 3.75736016059811e-05 0.000489342062800408 1.17785125154984 0.894736842105263 17.3 17 3 spleen hyperplasia 6.76326558355048e-17 6.34853703361579e-15 1.17600364174348 0.893333333333333 17.3 17 3 abnormal lymphocyte physiology 9.57586501452244e-11 3.85255379376088e-09 1.17333264061039 0.891304347826087 17.3 17 3 abnormal B cell differentiation 6.31326810758581e-20 9.23779671624688e-18 1.17176023021021 0.89010989010989 17.3 17 3 absent inner cell mass 7.83025355791714e-05 0.000931950034704253 1.1701528773567 0.888888888888889 17.3 17 3 abnormal hypoglossal nerve topology 7.83025355791714e-05 0.000931950034704253 1.1701528773567 0.888888888888889 17.3 17 3 heart hyperplasia 0.00668469439421146 0.0388508815551426 1.1701528773567 0.888888888888889 17.3 17 3 crypts of Lieberkuhn abscesses 0.00668469439421146 0.0388508815551426 1.1701528773567 0.888888888888889 17.3 17 3 decreased level of surface class I molecules 0.00668469439421146 0.0388508815551426 1.1701528773567 0.888888888888889 17.3 17 3 abnormal gut-associated lymphoid tissue morphology 0.00668469439421146 0.0388508815551426 1.1701528773567 0.888888888888889 17.3 17 3 abnormal posterior semicircular canal morphology 0.00668469439421146 0.0388508815551426 1.1701528773567 0.888888888888889 17.3 17 3 abnormal NMDA-mediated synaptic currents 0.00668469439421146 0.0388508815551426 1.1701528773567 0.888888888888889 17.3 17 3 abnormal thymus physiology 0.00668469439421146 0.0388508815551426 1.1701528773567 0.888888888888889 17.3 17 3 decreased cellular sensitivity to ionizing radiation 0.00668469439421146 0.0388508815551426 1.1701528773567 0.888888888888889 17.3 17 3 increased neuronal precursor cell number 0.00668469439421146 0.0388508815551426 1.1701528773567 0.888888888888889 17.3 17 3 abnormal inguinal fat pad morphology 0.00668469439421146 0.0388508815551426 1.1701528773567 0.888888888888889 17.3 17 3 decreased susceptibility to atherosclerosis 0.00668469439421146 0.0388508815551426 1.1701528773567 0.888888888888889 17.3 17 3 abnormal leukopoiesis 0.00668469439421146 0.0388508815551426 1.1701528773567 0.888888888888889 17.3 17 3 abnormal telomere morphology 0.00668469439421146 0.0388508815551426 1.1701528773567 0.888888888888889 17.3 17 3 reduced AMPA-mediated synaptic currents 0.00668469439421146 0.0388508815551426 1.1701528773567 0.888888888888889 17.3 17 3 symmetric azygos veins 0.00668469439421146 0.0388508815551426 1.1701528773567 0.888888888888889 17.3 17 3 increased cardiac muscle glycogen level 0.00668469439421146 0.0388508815551426 1.1701528773567 0.888888888888889 17.3 17 3 decreased platelet dense granule number 0.00668469439421146 0.0388508815551426 1.1701528773567 0.888888888888889 17.3 17 3 increased leukemia incidence 2.11918921749705e-06 3.86189243847906e-05 1.16452714236941 0.884615384615385 17.3 17 3 decreased Peyer's patch number 2.11918921749705e-06 3.86189243847906e-05 1.16452714236941 0.884615384615385 17.3 17 3 increased thymocyte apoptosis 2.11918921749705e-06 3.86189243847906e-05 1.16452714236941 0.884615384615385 17.3 17 3 impaired hematopoiesis 2.4948044310048e-11 1.09837628710167e-09 1.16154881208202 0.882352941176471 17.3 17 3 abnormal cytotoxic T cell physiology 1.73755982932504e-09 5.6499085953543e-08 1.15970508380887 0.880952380952381 17.3 17 3 increased pre-B cell number 4.36421643062482e-06 7.31042987958198e-05 1.15845134858313 0.88 17.3 17 3 decreased T cell proliferation 7.59299468492802e-30 2.69822489696549e-27 1.15631661022579 0.878378378378378 17.3 17 3 abnormal erythropoiesis 2.41538844356927e-21 4.62175288721428e-19 1.15343640768018 0.876190476190476 17.3 17 3 ocular hypertelorism 8.94378947480425e-06 0.000137756509712542 1.151869238648 0.875 17.3 17 3 decreased mast cell number 0.000333776194632705 0.00323061589162978 1.151869238648 0.875 17.3 17 3 decreased liver cholesterol level 0.000333776194632705 0.00323061589162978 1.151869238648 0.875 17.3 17 3 abnormal exoccipital bone morphology 0.0139013615363881 0.0710783901783463 1.151869238648 0.875 17.3 17 3 dry eyes 0.0139013615363881 0.0710783901783463 1.151869238648 0.875 17.3 17 3 abnormal erythrocyte cell number 0.0139013615363881 0.0710783901783463 1.151869238648 0.875 17.3 17 3 short ureter 0.0139013615363881 0.0710783901783463 1.151869238648 0.875 17.3 17 3 altered response to CNS ischemic injury 0.0139013615363881 0.0710783901783463 1.151869238648 0.875 17.3 17 3 abnormal cellular cholesterol metabolism 0.0139013615363881 0.0710783901783463 1.151869238648 0.875 17.3 17 3 liver failure 0.0139013615363881 0.0710783901783463 1.151869238648 0.875 17.3 17 3 tau protein deposits 0.0139013615363881 0.0710783901783463 1.151869238648 0.875 17.3 17 3 abnormal NK cell morphology 0.0139013615363881 0.0710783901783463 1.151869238648 0.875 17.3 17 3 abnormal choroid pigmentation 0.0139013615363881 0.0710783901783463 1.151869238648 0.875 17.3 17 3 abnormal epidermal lamellar body morphology 0.0139013615363881 0.0710783901783463 1.151869238648 0.875 17.3 17 3 enlarged inguinal lymph nodes 0.0139013615363881 0.0710783901783463 1.151869238648 0.875 17.3 17 3 abnormal meiotic spindle morphology 0.0139013615363881 0.0710783901783463 1.151869238648 0.875 17.3 17 3 abnormal mitotic spindle assembly checkpoint 0.0139013615363881 0.0710783901783463 1.151869238648 0.875 17.3 17 3 abnormal base-excision repair 0.0139013615363881 0.0710783901783463 1.151869238648 0.875 17.3 17 3 abnormal olfactory bulb mitral cell layer morphology 0.0139013615363881 0.0710783901783463 1.151869238648 0.875 17.3 17 3 pleural effusion 0.0139013615363881 0.0710783901783463 1.151869238648 0.875 17.3 17 3 delayed suture closure 0.0139013615363881 0.0710783901783463 1.151869238648 0.875 17.3 17 3 lung situs inversus 0.0139013615363881 0.0710783901783463 1.151869238648 0.875 17.3 17 3 embryo cyst 0.0139013615363881 0.0710783901783463 1.151869238648 0.875 17.3 17 3 abnormal cell nucleus morphology 4.35149367259469e-10 1.56874500153323e-08 1.14836811634208 0.872340425531915 17.3 17 3 increased autoantibody level 1.48040268927068e-08 4.18466101086457e-07 1.14764993740753 0.871794871794872 17.3 17 3 inner cell mass degeneration 5.12417960334532e-07 1.12501930965286e-05 1.14656108547451 0.870967741935484 17.3 17 3 abnormal B cell morphology 1.82321030079988e-05 0.000260645725473546 1.14471477132721 0.869565217391304 17.3 17 3 increased double-negative T cell number 1.59578627130629e-12 8.35688073657765e-11 1.14377648053104 0.868852459016393 17.3 17 3 macrocytosis 0.000681670228464447 0.00598114530266424 1.14089905542278 0.866666666666667 17.3 17 3 abnormal lymph node B cell domain morphology 0.000681670228464447 0.00598114530266424 1.14089905542278 0.866666666666667 17.3 17 3 abnormal placenta size 0.000681670228464447 0.00598114530266424 1.14089905542278 0.866666666666667 17.3 17 3 abnormal trophectoderm morphology 0.000681670228464447 0.00598114530266424 1.14089905542278 0.866666666666667 17.3 17 3 immune system phenotype 0.000681670228464447 0.00598114530266424 1.14089905542278 0.866666666666667 17.3 17 3 abnormal microglial cell activation 0.000681670228464447 0.00598114530266424 1.14089905542278 0.866666666666667 17.3 17 3 decreased IgA level 1.07358943827152e-10 4.23897417095301e-09 1.1392113349266 0.865384615384615 17.3 17 3 abnormal leukocyte migration 1.07358943827152e-10 4.23897417095301e-09 1.1392113349266 0.865384615384615 17.3 17 3 increased myocardial infarction size 3.69529703787224e-05 0.00048379217798459 1.13690989788634 0.863636363636364 17.3 17 3 abnormal lysosome physiology 3.69529703787224e-05 0.00048379217798459 1.13690989788634 0.863636363636364 17.3 17 3 embryonic lethality before implantation, incomplete penetrance 3.69529703787224e-05 0.00048379217798459 1.13690989788634 0.863636363636364 17.3 17 3 abnormal CD8-positive, alpha-beta T cell physiology 2.09730165769341e-06 3.86189243847906e-05 1.1348465405399 0.862068965517241 17.3 17 3 decreased double-positive T cell number 6.97405306639592e-19 8.26093190602851e-17 1.13212290884261 0.86 17.3 17 3 abnormal CD4-positive, alpha-beta T cell physiology 9.7361148147529e-14 5.90697209797508e-12 1.1310104395578 0.859154929577465 17.3 17 3 subcutaneous edema 4.21211256023668e-06 7.10347796175508e-05 1.12836170316539 0.857142857142857 17.3 17 3 vascular smooth muscle hypoplasia 0.00138035404500517 0.0108831400537254 1.12836170316539 0.857142857142857 17.3 17 3 abnormal positive T cell selection 0.00138035404500517 0.0108831400537254 1.12836170316539 0.857142857142857 17.3 17 3 lysosomal protein accumulation 0.00138035404500517 0.0108831400537254 1.12836170316539 0.857142857142857 17.3 17 3 testis degeneration 0.00138035404500517 0.0108831400537254 1.12836170316539 0.857142857142857 17.3 17 3 multiple persisting craniopharyngeal ducts 0.00138035404500517 0.0108831400537254 1.12836170316539 0.857142857142857 17.3 17 3 abnormal vitelline vein topology 0.00138035404500517 0.0108831400537254 1.12836170316539 0.857142857142857 17.3 17 3 decreased response to antigen 0.00138035404500517 0.0108831400537254 1.12836170316539 0.857142857142857 17.3 17 3 asymmetric rib joints 0.028531146524762 0.121734523122377 1.12836170316539 0.857142857142857 17.3 17 3 broad head 0.028531146524762 0.121734523122377 1.12836170316539 0.857142857142857 17.3 17 3 abnormal circulating free fatty acids level 0.028531146524762 0.121734523122377 1.12836170316539 0.857142857142857 17.3 17 3 abnormal brain ventricular system morphology 0.028531146524762 0.121734523122377 1.12836170316539 0.857142857142857 17.3 17 3 decreased cardiomyocyte apoptosis 0.028531146524762 0.121734523122377 1.12836170316539 0.857142857142857 17.3 17 3 aorta coarctation 0.028531146524762 0.121734523122377 1.12836170316539 0.857142857142857 17.3 17 3 increased cell nucleus count 0.028531146524762 0.121734523122377 1.12836170316539 0.857142857142857 17.3 17 3 abnormal nephron morphology 0.028531146524762 0.121734523122377 1.12836170316539 0.857142857142857 17.3 17 3 atherosclerotic lesions 0.028531146524762 0.121734523122377 1.12836170316539 0.857142857142857 17.3 17 3 increased chronic myelocytic leukemia incidence 0.028531146524762 0.121734523122377 1.12836170316539 0.857142857142857 17.3 17 3 decreased tidal volume 0.028531146524762 0.121734523122377 1.12836170316539 0.857142857142857 17.3 17 3 increased keratinocyte apoptosis 0.028531146524762 0.121734523122377 1.12836170316539 0.857142857142857 17.3 17 3 absent popliteal lymph nodes 0.028531146524762 0.121734523122377 1.12836170316539 0.857142857142857 17.3 17 3 abnormal uterus physiology 0.028531146524762 0.121734523122377 1.12836170316539 0.857142857142857 17.3 17 3 abnormal spinal cord central canal morphology 0.028531146524762 0.121734523122377 1.12836170316539 0.857142857142857 17.3 17 3 decreased DN4 thymocyte number 0.028531146524762 0.121734523122377 1.12836170316539 0.857142857142857 17.3 17 3 arteritis 0.028531146524762 0.121734523122377 1.12836170316539 0.857142857142857 17.3 17 3 coronary fistula 0.028531146524762 0.121734523122377 1.12836170316539 0.857142857142857 17.3 17 3 abnormal aortic valve cusp morphology 0.028531146524762 0.121734523122377 1.12836170316539 0.857142857142857 17.3 17 3 abnormal outer hair cell kinocilium morphology 0.028531146524762 0.121734523122377 1.12836170316539 0.857142857142857 17.3 17 3 embryonic lethality at implantation, incomplete penetrance 0.028531146524762 0.121734523122377 1.12836170316539 0.857142857142857 17.3 17 3 parturition failure 0.028531146524762 0.121734523122377 1.12836170316539 0.857142857142857 17.3 17 3 ductus venosus stenosis 0.028531146524762 0.121734523122377 1.12836170316539 0.857142857142857 17.3 17 3 absent connection between subcutaneous lymph vessels and lymph sac 0.028531146524762 0.121734523122377 1.12836170316539 0.857142857142857 17.3 17 3 embryonic lethality between somite formation and embryo turning, complete penetrance 1.94589729884718e-13 1.13892224256055e-11 1.12836170316539 0.857142857142857 17.3 17 3 increased acute inflammation 7.44267022271814e-05 0.000894378849227603 1.12836170316539 0.857142857142857 17.3 17 3 vertebral transformation 1.73156468770153e-09 5.6499085953543e-08 1.12444378058495 0.854166666666667 17.3 17 3 enlarged liver sinusoidal spaces 4.88998826815036e-07 1.08123073929102e-05 1.12283051834595 0.852941176470588 17.3 17 3 abnormal direction of heart looping 4.88998826815036e-07 1.08123073929102e-05 1.12283051834595 0.852941176470588 17.3 17 3 abnormal cytokine secretion 4.63836188928394e-27 1.44224064994922e-24 1.11981350844444 0.850649350649351 17.3 17 3 increased T cell proliferation 3.31640085940648e-19 4.34186691461769e-17 1.11957383943357 0.850467289719626 17.3 17 3 abnormal vascular regression 0.000148871324918985 0.00162064516733468 1.11895868897235 0.85 17.3 17 3 increased mammary adenocarcinoma incidence 0.000148871324918985 0.00162064516733468 1.11895868897235 0.85 17.3 17 3 abnormal physiological neovascularization 0.000148871324918985 0.00162064516733468 1.11895868897235 0.85 17.3 17 3 abnormal response to infection 2.26514445307215e-14 1.48277548079394e-12 1.11645915355394 0.848101265822785 17.3 17 3 embryonic lethality between implantation and placentation, complete penetrance 6.81904567990864e-09 2.06858245472838e-07 1.11609690204403 0.847826086956522 17.3 17 3 abnormal leukocyte cell number 1.67118661028275e-05 0.000241690505411532 1.11389552748378 0.846153846153846 17.3 17 3 heart inflammation 1.67118661028275e-05 0.000241690505411532 1.11389552748378 0.846153846153846 17.3 17 3 abnormal tail bud morphology 0.00276806377492353 0.0193707878742637 1.11389552748378 0.846153846153846 17.3 17 3 abnormal coping response 0.00276806377492353 0.0193707878742637 1.11389552748378 0.846153846153846 17.3 17 3 abnormal telomere length 0.00276806377492353 0.0193707878742637 1.11389552748378 0.846153846153846 17.3 17 3 small otic vesicle 0.00276806377492353 0.0193707878742637 1.11389552748378 0.846153846153846 17.3 17 3 absent hypoglossal nerve 0.00276806377492353 0.0193707878742637 1.11389552748378 0.846153846153846 17.3 17 3 decreased IgM level 4.11938854580822e-17 4.01842314027371e-15 1.1128515766614 0.845360824742268 17.3 17 3 abnormal spongiotrophoblast layer morphology 1.92087228291204e-06 3.57915341104398e-05 1.11073105155343 0.84375 17.3 17 3 increased fatty acid level 1.92087228291204e-06 3.57915341104398e-05 1.11073105155343 0.84375 17.3 17 3 abnormal cell morphology 1.48272032503705e-19 2.10758103344553e-17 1.10856588381161 0.842105263157895 17.3 17 3 decreased susceptibility to induced arthritis 1.92237079495848e-10 7.30060664497592e-09 1.10856588381161 0.842105263157895 17.3 17 3 abnormal triglyceride level 0.000295523516769519 0.00290559188918647 1.10856588381161 0.842105263157895 17.3 17 3 small superior vagus ganglion 0.000295523516769519 0.00290559188918647 1.10856588381161 0.842105263157895 17.3 17 3 decreased tumor incidence 0.000295523516769519 0.00290559188918647 1.10856588381161 0.842105263157895 17.3 17 3 abnormal myelopoiesis 2.64631330622318e-08 7.18301122056324e-07 1.10699121636302 0.840909090909091 17.3 17 3 increased monocyte cell number 3.80638138615803e-17 3.78734947922724e-15 1.10579446910208 0.84 17.3 17 3 decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 3.29865479567461e-05 0.00043996803239896 1.10579446910208 0.84 17.3 17 3 abnormal CD8-positive, alpha beta T cell morphology 3.77780836700526e-06 6.52590160619832e-05 1.10409586008656 0.838709677419355 17.3 17 3 impaired macrophage phagocytosis 5.18232666555793e-08 1.31541199801789e-06 1.10212073332433 0.837209302325581 17.3 17 3 abnormal double-strand DNA break repair 5.18232666555793e-08 1.31541199801789e-06 1.10212073332433 0.837209302325581 17.3 17 3 spina bifida 1.01060266967476e-07 2.44065450564658e-06 1.09701832252191 0.833333333333333 17.3 17 3 abnormal trophoblast giant cell morphology 8.58903641394523e-07 1.80297283372901e-05 1.09701832252191 0.833333333333333 17.3 17 3 abnormal spleen marginal zone morphology 7.38834078426945e-06 0.00011631960570171 1.09701832252191 0.833333333333333 17.3 17 3 abnormal microglial cell physiology 7.38834078426945e-06 0.00011631960570171 1.09701832252191 0.833333333333333 17.3 17 3 underdeveloped hair follicles 0.000581726635937335 0.00533964947193402 1.09701832252191 0.833333333333333 17.3 17 3 abnormal metacarpal bone morphology 0.000581726635937335 0.00533964947193402 1.09701832252191 0.833333333333333 17.3 17 3 decreased cellular sensitivity to gamma-irradiation 0.000581726635937335 0.00533964947193402 1.09701832252191 0.833333333333333 17.3 17 3 long tibia 0.000581726635937335 0.00533964947193402 1.09701832252191 0.833333333333333 17.3 17 3 abnormal macrophage chemotaxis 0.000581726635937335 0.00533964947193402 1.09701832252191 0.833333333333333 17.3 17 3 abnormal aerobic respiration 0.000581726635937335 0.00533964947193402 1.09701832252191 0.833333333333333 17.3 17 3 impaired leukocyte tethering or rolling 0.000581726635937335 0.00533964947193402 1.09701832252191 0.833333333333333 17.3 17 3 myocarditis 0.00548885887184015 0.0346097248256081 1.09701832252191 0.833333333333333 17.3 17 3 altered tumor susceptibility 0.00548885887184015 0.0346097248256081 1.09701832252191 0.833333333333333 17.3 17 3 increased growth rate 0.00548885887184015 0.0346097248256081 1.09701832252191 0.833333333333333 17.3 17 3 small intestinal inflammation 0.00548885887184015 0.0346097248256081 1.09701832252191 0.833333333333333 17.3 17 3 abnormal vascular endothelial cell development 0.00548885887184015 0.0346097248256081 1.09701832252191 0.833333333333333 17.3 17 3 increased osteosarcoma incidence 0.00548885887184015 0.0346097248256081 1.09701832252191 0.833333333333333 17.3 17 3 abnormal palatine bone morphology 0.00548885887184015 0.0346097248256081 1.09701832252191 0.833333333333333 17.3 17 3 persistent right dorsal aorta 0.00548885887184015 0.0346097248256081 1.09701832252191 0.833333333333333 17.3 17 3 prenatal growth retardation 0.00548885887184015 0.0346097248256081 1.09701832252191 0.833333333333333 17.3 17 3 abnormal vitelline vein connection 0.00548885887184015 0.0346097248256081 1.09701832252191 0.833333333333333 17.3 17 3 large anterior fontanelle 0.057582576117893 0.202597819085232 1.09701832252191 0.833333333333333 17.3 17 3 absent organized vascular network 0.057582576117893 0.202597819085232 1.09701832252191 0.833333333333333 17.3 17 3 abnormal lens induction 0.057582576117893 0.202597819085232 1.09701832252191 0.833333333333333 17.3 17 3 absent ectoplacental cone 0.057582576117893 0.202597819085232 1.09701832252191 0.833333333333333 17.3 17 3 non-obstructive hydrocephaly 0.057582576117893 0.202597819085232 1.09701832252191 0.833333333333333 17.3 17 3 abnormal blood gas level 0.057582576117893 0.202597819085232 1.09701832252191 0.833333333333333 17.3 17 3 abnormal lymph node cortex morphology 0.057582576117893 0.202597819085232 1.09701832252191 0.833333333333333 17.3 17 3 chromatolysis 0.057582576117893 0.202597819085232 1.09701832252191 0.833333333333333 17.3 17 3 increased post-tetanic potentiation 0.057582576117893 0.202597819085232 1.09701832252191 0.833333333333333 17.3 17 3 abnormal hippocampal fimbria morphology 0.057582576117893 0.202597819085232 1.09701832252191 0.833333333333333 17.3 17 3 liver cirrhosis 0.057582576117893 0.202597819085232 1.09701832252191 0.833333333333333 17.3 17 3 calcified joint 0.057582576117893 0.202597819085232 1.09701832252191 0.833333333333333 17.3 17 3 bile duct inflammation 0.057582576117893 0.202597819085232 1.09701832252191 0.833333333333333 17.3 17 3 decreased liver function 0.057582576117893 0.202597819085232 1.09701832252191 0.833333333333333 17.3 17 3 matted coat 0.057582576117893 0.202597819085232 1.09701832252191 0.833333333333333 17.3 17 3 abnormal cholesterol level 0.057582576117893 0.202597819085232 1.09701832252191 0.833333333333333 17.3 17 3 small clavicle 0.057582576117893 0.202597819085232 1.09701832252191 0.833333333333333 17.3 17 3 absent cochlear nerve compound action potential 0.057582576117893 0.202597819085232 1.09701832252191 0.833333333333333 17.3 17 3 absent parietal bone 0.057582576117893 0.202597819085232 1.09701832252191 0.833333333333333 17.3 17 3 abnormal blastocoele morphology 0.057582576117893 0.202597819085232 1.09701832252191 0.833333333333333 17.3 17 3 abnormal T cell clonal deletion 0.057582576117893 0.202597819085232 1.09701832252191 0.833333333333333 17.3 17 3 impaired granulocyte bactericidal activity 0.057582576117893 0.202597819085232 1.09701832252191 0.833333333333333 17.3 17 3 decreased platelet ADP level 0.057582576117893 0.202597819085232 1.09701832252191 0.833333333333333 17.3 17 3 absent brachial lymph nodes 0.057582576117893 0.202597819085232 1.09701832252191 0.833333333333333 17.3 17 3 delayed chorioallantoic fusion 0.057582576117893 0.202597819085232 1.09701832252191 0.833333333333333 17.3 17 3 abnormal olfactory bulb layer morphology 0.057582576117893 0.202597819085232 1.09701832252191 0.833333333333333 17.3 17 3 abnormal oval cell physiology 0.057582576117893 0.202597819085232 1.09701832252191 0.833333333333333 17.3 17 3 enlarged lymphatic vessel 0.057582576117893 0.202597819085232 1.09701832252191 0.833333333333333 17.3 17 3 abnormal acute phase protein level 0.057582576117893 0.202597819085232 1.09701832252191 0.833333333333333 17.3 17 3 abnormal heart right ventricle outflow tract morphology 0.057582576117893 0.202597819085232 1.09701832252191 0.833333333333333 17.3 17 3 myocardium hypoplasia 0.057582576117893 0.202597819085232 1.09701832252191 0.833333333333333 17.3 17 3 thick pulmonary valve cusps 0.057582576117893 0.202597819085232 1.09701832252191 0.833333333333333 17.3 17 3 thick myocardium 0.057582576117893 0.202597819085232 1.09701832252191 0.833333333333333 17.3 17 3 abnormal intestinal enteroendocrine cell morphology 0.057582576117893 0.202597819085232 1.09701832252191 0.833333333333333 17.3 17 3 abnormal mandibular prominence morphology 0.057582576117893 0.202597819085232 1.09701832252191 0.833333333333333 17.3 17 3 increased macrophage apoptosis 0.057582576117893 0.202597819085232 1.09701832252191 0.833333333333333 17.3 17 3 increased effector memory T-helper cell number 0.057582576117893 0.202597819085232 1.09701832252191 0.833333333333333 17.3 17 3 abnormal Wolffian duct connection 0.057582576117893 0.202597819085232 1.09701832252191 0.833333333333333 17.3 17 3 ectopic bone 0.057582576117893 0.202597819085232 1.09701832252191 0.833333333333333 17.3 17 3 decreased tear production 0.057582576117893 0.202597819085232 1.09701832252191 0.833333333333333 17.3 17 3 decreased retinal apoptosis 0.057582576117893 0.202597819085232 1.09701832252191 0.833333333333333 17.3 17 3 abnormal T cell differentiation 1.30116797191735e-16 1.17696557459796e-14 1.09484600901196 0.831683168316832 17.3 17 3 increased tumor incidence 5.64422952844101e-20 8.50910360727092e-18 1.09347955373958 0.830645161290323 17.3 17 3 extramedullary hematopoiesis 3.07850867130985e-17 3.12562870199316e-15 1.09287863073881 0.830188679245283 17.3 17 3 increased cellular sensitivity to gamma-irradiation 2.32809389492461e-08 6.43459284847219e-07 1.09235015944735 0.829787234042553 17.3 17 3 increased T cell number 1.69150382243379e-14 1.12223274649586e-12 1.09203187560135 0.829545454545455 17.3 17 3 abnormal cell differentiation 1.9620821740252e-07 4.5613826241941e-06 1.09166701363156 0.829268292682927 17.3 17 3 increased B cell number 8.9112286077656e-19 1.03100842613102e-16 1.09139258753462 0.829059829059829 17.3 17 3 decreased bone volume 1.66844320716336e-06 3.20482816819988e-05 1.09074964639321 0.828571428571429 17.3 17 3 liver hypoplasia 5.37628038868201e-09 1.67168718335581e-07 1.08857972004097 0.826923076923077 17.3 17 3 decreased T cell number 6.31680697734617e-25 1.49648165296653e-22 1.08747903276085 0.826086956521739 17.3 17 3 decreased B cell number 2.32289380666917e-31 9.63033057348258e-29 1.08636765919645 0.825242718446602 17.3 17 3 impaired natural killer cell mediated cytotoxicity 1.24418741383407e-09 4.18231917825979e-08 1.0854707612322 0.824561403508772 17.3 17 3 increased granulocyte number 4.24227271594552e-12 2.06914772174794e-10 1.08515866498113 0.824324324324324 17.3 17 3 increased lung adenocarcinoma incidence 1.03542129983282e-08 3.06620295635017e-07 1.08411222460988 0.823529411764706 17.3 17 3 abnormal spleen red pulp morphology 3.22357979760279e-06 5.65389471974045e-05 1.08411222460988 0.823529411764706 17.3 17 3 abnormal brown adipose tissue morphology 3.22357979760279e-06 5.65389471974045e-05 1.08411222460988 0.823529411764706 17.3 17 3 decreased regulatory T cell number 3.22357979760279e-06 5.65389471974045e-05 1.08411222460988 0.823529411764706 17.3 17 3 abnormal bone marrow cavity morphology 0.00113443452549284 0.00939070177092663 1.08411222460988 0.823529411764706 17.3 17 3 abnormal ectoplacental cone morphology 0.00113443452549284 0.00939070177092663 1.08411222460988 0.823529411764706 17.3 17 3 increased trabecular bone mass 0.00113443452549284 0.00939070177092663 1.08411222460988 0.823529411764706 17.3 17 3 enlarged spleen 9.0701596265888e-43 6.44629202032561e-40 1.08330559349038 0.822916666666667 17.3 17 3 lymphoid hyperplasia 2.774387467845e-05 0.000380236298967738 1.08134663220017 0.821428571428571 17.3 17 3 abnormal spleen germinal center morphology 2.774387467845e-05 0.000380236298967738 1.08134663220017 0.821428571428571 17.3 17 3 abnormal brainstem morphology 2.774387467845e-05 0.000380236298967738 1.08134663220017 0.821428571428571 17.3 17 3 abnormal mitotic spindle morphology 2.774387467845e-05 0.000380236298967738 1.08134663220017 0.821428571428571 17.3 17 3 increased inflammatory response 6.63763510632062e-15 5.00336888696138e-13 1.08085173671632 0.821052631578947 17.3 17 3 small liver 1.89854492426224e-12 9.63802142673946e-11 1.08014111756003 0.82051282051282 17.3 17 3 increased embryonic tissue cell apoptosis 1.89854492426224e-12 9.63802142673946e-11 1.08014111756003 0.82051282051282 17.3 17 3 impaired macrophage chemotaxis 7.29179010354318e-07 1.53714643072573e-05 1.08014111756003 0.82051282051282 17.3 17 3 decreased lymphocyte cell number 1.59273070958179e-19 2.20106535560261e-17 1.0798774112325 0.8203125 17.3 17 3 abnormal NK cell physiology 5.52512798064673e-10 1.94946891515727e-08 1.07903441559532 0.819672131147541 17.3 17 3 abnormal vascular branching morphogenesis 0.000243058495545248 0.00245775612873498 1.07707253483969 0.818181818181818 17.3 17 3 abnormal mesenteric lymph node morphology 0.000243058495545248 0.00245775612873498 1.07707253483969 0.818181818181818 17.3 17 3 abnormal occipital bone morphology 0.000243058495545248 0.00245775612873498 1.07707253483969 0.818181818181818 17.3 17 3 increased mammary gland tumor incidence 0.000243058495545248 0.00245775612873498 1.07707253483969 0.818181818181818 17.3 17 3 increased adenoma incidence 0.000243058495545248 0.00245775612873498 1.07707253483969 0.818181818181818 17.3 17 3 abnormal hemoglobin 0.0107423208449793 0.0577798981768873 1.07707253483969 0.818181818181818 17.3 17 3 increased glycogen level 0.0107423208449793 0.0577798981768873 1.07707253483969 0.818181818181818 17.3 17 3 abnormal superovulation 0.0107423208449793 0.0577798981768873 1.07707253483969 0.818181818181818 17.3 17 3 aberrant origin of the right subclavian artery 0.0107423208449793 0.0577798981768873 1.07707253483969 0.818181818181818 17.3 17 3 decreased embryonic cilium length 0.0107423208449793 0.0577798981768873 1.07707253483969 0.818181818181818 17.3 17 3 hypolactation 0.0107423208449793 0.0577798981768873 1.07707253483969 0.818181818181818 17.3 17 3 thin hypoglossal nerve 0.0107423208449793 0.0577798981768873 1.07707253483969 0.818181818181818 17.3 17 3 abnormal skeleton physiology 6.19272382913475e-06 0.000100028574837485 1.07707253483969 0.818181818181818 17.3 17 3 decreased brown adipose tissue amount 6.19272382913475e-06 0.000100028574837485 1.07707253483969 0.818181818181818 17.3 17 3 increased osteoblast cell number 6.19272382913475e-06 0.000100028574837485 1.07707253483969 0.818181818181818 17.3 17 3 increased sarcoma incidence 3.79464284035668e-08 9.88395190092905e-07 1.07463019349085 0.816326530612245 17.3 17 3 embryonic lethality before implantation, complete penetrance 1.10422566078293e-18 1.24852787781706e-16 1.07420034141345 0.816 17.3 17 3 abnormal apoptosis 8.7108671500425e-09 2.62645842857342e-07 1.07264013757698 0.814814814814815 17.3 17 3 scoliosis 1.18245313980759e-05 0.000175080487218535 1.06959286445886 0.8125 17.3 17 3 disorganized yolk sac vascular plexus 0.00218921104173533 0.0160876291471688 1.06959286445886 0.8125 17.3 17 3 increased cochlear outer hair cell number 0.00218921104173533 0.0160876291471688 1.06959286445886 0.8125 17.3 17 3 impaired somite development 0.00218921104173533 0.0160876291471688 1.06959286445886 0.8125 17.3 17 3 decreased fibroblast apoptosis 0.00218921104173533 0.0160876291471688 1.06959286445886 0.8125 17.3 17 3 abnormal T cell activation 2.48477819224965e-11 1.09837628710167e-09 1.06736917866996 0.810810810810811 17.3 17 3 abnormal chromosome morphology 2.6545678906778e-06 4.73350367602941e-05 1.06736917866996 0.810810810810811 17.3 17 3 abnormal humoral immune response 2.10149784326693e-15 1.77202572377169e-13 1.06567494187842 0.80952380952381 17.3 17 3 abnormal hematopoietic system physiology 0.000465260971359149 0.00438385100854501 1.06567494187842 0.80952380952381 17.3 17 3 increased incidence of induced tumors 0.000465260971359149 0.00438385100854501 1.06567494187842 0.80952380952381 17.3 17 3 liver degeneration 0.000465260971359149 0.00438385100854501 1.06567494187842 0.80952380952381 17.3 17 3 abnormal erythrocyte physiology 0.000465260971359149 0.00438385100854501 1.06567494187842 0.80952380952381 17.3 17 3 absent segment of posterior cerebral artery 0.000465260971359149 0.00438385100854501 1.06567494187842 0.80952380952381 17.3 17 3 abnormal T-helper 1 physiology 1.36697990317996e-07 3.23844048491443e-06 1.06434118099998 0.808510638297872 17.3 17 3 decreased bone marrow cell number 4.69143953095024e-11 1.96133711483004e-09 1.06395749636371 0.808219178082192 17.3 17 3 abnormal placenta vasculature 3.12615299588419e-08 8.36161890028163e-07 1.06326391259816 0.807692307692308 17.3 17 3 decreased bone resorption 0.000101340211743205 0.0011616763903743 1.06326391259816 0.807692307692308 17.3 17 3 abnormal definitive hematopoiesis 1.36989671714245e-13 8.2111279129924e-12 1.06163063469862 0.806451612903226 17.3 17 3 osteopetrosis 2.24322258562036e-05 0.000314367108829895 1.06163063469862 0.806451612903226 17.3 17 3 autoimmune response 2.24322258562036e-05 0.000314367108829895 1.06163063469862 0.806451612903226 17.3 17 3 abnormal pharyngeal arch morphology 5.02224997963426e-06 8.32856454956015e-05 1.06045104510451 0.805555555555556 17.3 17 3 decreased cell proliferation 1.7087214219898e-25 4.7409436598121e-23 1.0602533841455 0.805405405405405 17.3 17 3 arrested B cell differentiation 1.13390097126989e-06 2.27466021454343e-05 1.05955916028945 0.804878048780488 17.3 17 3 abnormal vascular development 7.16395596242467e-10 2.45990535430348e-08 1.05712674715747 0.803030303030303 17.3 17 3 increased grip strength 4.81788991349344e-13 2.63395629886043e-11 1.05603082475735 0.802197802197802 17.3 17 3 abnormal embryo turning 2.52720135033723e-08 6.94631310382747e-07 1.05313758962103 0.8 17.3 17 3 liver hemorrhage 4.22626613251445e-05 0.000541898814671633 1.05313758962103 0.8 17.3 17 3 ruffled hair 0.000191422161542877 0.00202192198232656 1.05313758962103 0.8 17.3 17 3 spontaneous skin ulceration 0.000191422161542877 0.00202192198232656 1.05313758962103 0.8 17.3 17 3 increased cellular sensitivity to ionizing radiation 0.000191422161542877 0.00202192198232656 1.05313758962103 0.8 17.3 17 3 abnormal pericardium morphology 0.000882132284171654 0.00745094756155175 1.05313758962103 0.8 17.3 17 3 brain inflammation 0.000882132284171654 0.00745094756155175 1.05313758962103 0.8 17.3 17 3 spleen atrophy 0.000882132284171654 0.00745094756155175 1.05313758962103 0.8 17.3 17 3 abnormal neuron proliferation 0.000882132284171654 0.00745094756155175 1.05313758962103 0.8 17.3 17 3 increased skin tumor incidence 0.000882132284171654 0.00745094756155175 1.05313758962103 0.8 17.3 17 3 arthritis 0.00417508931116809 0.0271872635118603 1.05313758962103 0.8 17.3 17 3 decreased thymocyte apoptosis 0.00417508931116809 0.0271872635118603 1.05313758962103 0.8 17.3 17 3 abnormal lateral semicircular canal morphology 0.0207011791744655 0.0955365179897645 1.05313758962103 0.8 17.3 17 3 fused cornea and lens 0.0207011791744655 0.0955365179897645 1.05313758962103 0.8 17.3 17 3 abnormal immune cell physiology 0.0207011791744655 0.0955365179897645 1.05313758962103 0.8 17.3 17 3 abnormal airway responsiveness 0.0207011791744655 0.0955365179897645 1.05313758962103 0.8 17.3 17 3 peritoneal inflammation 0.0207011791744655 0.0955365179897645 1.05313758962103 0.8 17.3 17 3 absent pharyngeal arches 0.0207011791744655 0.0955365179897645 1.05313758962103 0.8 17.3 17 3 abnormal plasma membrane morphology 0.0207011791744655 0.0955365179897645 1.05313758962103 0.8 17.3 17 3 abnormal embryonic erythrocyte morphology 0.0207011791744655 0.0955365179897645 1.05313758962103 0.8 17.3 17 3 abnormal deltoid tuberosity morphology 0.0207011791744655 0.0955365179897645 1.05313758962103 0.8 17.3 17 3 abnormal corneal endothelium morphology 0.0207011791744655 0.0955365179897645 1.05313758962103 0.8 17.3 17 3 ascites 0.0207011791744655 0.0955365179897645 1.05313758962103 0.8 17.3 17 3 abnormal gonadal fat pad morphology 0.0207011791744655 0.0955365179897645 1.05313758962103 0.8 17.3 17 3 osteosclerosis 0.0207011791744655 0.0955365179897645 1.05313758962103 0.8 17.3 17 3 tachypnea 0.0207011791744655 0.0955365179897645 1.05313758962103 0.8 17.3 17 3 increased platelet aggregation 0.0207011791744655 0.0955365179897645 1.05313758962103 0.8 17.3 17 3 absent axillary lymph nodes 0.0207011791744655 0.0955365179897645 1.05313758962103 0.8 17.3 17 3 increased circulating fructosamine level 0.0207011791744655 0.0955365179897645 1.05313758962103 0.8 17.3 17 3 increased T-helper 17 cell number 0.0207011791744655 0.0955365179897645 1.05313758962103 0.8 17.3 17 3 abnormal left subclavian artery morphology 0.0207011791744655 0.0955365179897645 1.05313758962103 0.8 17.3 17 3 thin ventricle myocardium compact layer 0.0207011791744655 0.0955365179897645 1.05313758962103 0.8 17.3 17 3 fusion of atlas and odontoid process 0.0207011791744655 0.0955365179897645 1.05313758962103 0.8 17.3 17 3 decreased trabecular bone connectivity density 0.0207011791744655 0.0955365179897645 1.05313758962103 0.8 17.3 17 3 increased compact bone area 0.0207011791744655 0.0955365179897645 1.05313758962103 0.8 17.3 17 3 abnormal adaptive thermogenesis 0.0207011791744655 0.0955365179897645 1.05313758962103 0.8 17.3 17 3 abnormal circadian temperature homeostasis 0.0207011791744655 0.0955365179897645 1.05313758962103 0.8 17.3 17 3 increased fatty acid oxidation 0.0207011791744655 0.0955365179897645 1.05313758962103 0.8 17.3 17 3 pale liver 1.33709741298395e-10 5.23784222802768e-09 1.0495796923588 0.797297297297297 17.3 17 3 thymus hypoplasia 1.50760416068224e-18 1.66674015542092e-16 1.04932187371661 0.797101449275362 17.3 17 3 anemia 1.82227303727853e-27 6.04387224030714e-25 1.0481464162105 0.796208530805687 17.3 17 3 decreased erythrocyte cell number 8.42168339944097e-21 1.55177314489699e-18 1.0481066775687 0.796178343949045 17.3 17 3 osteoporosis 9.01859881412413e-07 1.86948037917782e-05 1.04715385331637 0.795454545454545 17.3 17 3 decreased blood urea nitrogen level 9.01859881412413e-07 1.86948037917782e-05 1.04715385331637 0.795454545454545 17.3 17 3 failure of heart looping 3.97537177818248e-06 6.79638302283774e-05 1.04638670763628 0.794871794871795 17.3 17 3 decreased trabecular bone volume 3.97537177818248e-06 6.79638302283774e-05 1.04638670763628 0.794871794871795 17.3 17 3 astrocytosis 2.4833410169669e-10 9.28918914241377e-09 1.04592431845924 0.794520547945205 17.3 17 3 increased leukocyte cell number 5.26743218012691e-19 6.39157929173937e-17 1.04405881729671 0.793103448275862 17.3 17 3 increased mortality induced by gamma-irradiation 7.90364421914712e-05 0.00093398170998235 1.04405881729671 0.793103448275862 17.3 17 3 increased double-positive T cell number 7.90364421914712e-05 0.00093398170998235 1.04405881729671 0.793103448275862 17.3 17 3 blood in lymph vessels 7.90364421914712e-05 0.00093398170998235 1.04405881729671 0.793103448275862 17.3 17 3 decreased IgG level 7.38960069833951e-15 5.48705424988643e-13 1.04364986358841 0.792792792792793 17.3 17 3 embryonic lethality between implantation and somite formation, complete penetrance 6.66137785478494e-31 2.54925806365808e-28 1.04239128768612 0.791836734693877 17.3 17 3 decreased body height 0.000358450085309269 0.00343568581650286 1.04216740639581 0.791666666666667 17.3 17 3 decreased fatty acid level 0.000358450085309269 0.00343568581650286 1.04216740639581 0.791666666666667 17.3 17 3 increased body temperature 0.000358450085309269 0.00343568581650286 1.04216740639581 0.791666666666667 17.3 17 3 abnormal cellular extravasation 0.000358450085309269 0.00343568581650286 1.04216740639581 0.791666666666667 17.3 17 3 embryonic lethality, complete penetrance 2.1094957557533e-39 1.31184267310908e-36 1.03993210260384 0.789968652037618 17.3 17 3 incomplete embryo turning 3.71888018251947e-08 9.73759416212334e-07 1.03928051607339 0.789473684210526 17.3 17 3 decreased brain weight 3.71888018251947e-08 9.73759416212334e-07 1.03928051607339 0.789473684210526 17.3 17 3 decreased neuron apoptosis 7.37770483202309e-06 0.00011631960570171 1.03928051607339 0.789473684210526 17.3 17 3 increased liver adenoma incidence 0.00165498833281665 0.0125703312301723 1.03928051607339 0.789473684210526 17.3 17 3 decreased liver regeneration 0.00165498833281665 0.0125703312301723 1.03928051607339 0.789473684210526 17.3 17 3 decreased embryo size 5.05373848175952e-58 4.19039149112561e-55 1.03826587679688 0.788702928870293 17.3 17 3 myeloid hyperplasia 3.27426737970003e-05 0.000437889253064722 1.03718095947526 0.787878787878788 17.3 17 3 decreased neutrophil cell number 4.65230669128663e-15 3.68739791582895e-13 1.0351352376617 0.786324786324786 17.3 17 3 small superior cervical ganglion 0.000146639646299961 0.00161400938128829 1.03433156123494 0.785714285714286 17.3 17 3 premature aging 0.000146639646299961 0.00161400938128829 1.03433156123494 0.785714285714286 17.3 17 3 midline facial cleft 0.00785633278462416 0.0440645497221028 1.03433156123494 0.785714285714286 17.3 17 3 amyloid beta deposits 0.00785633278462416 0.0440645497221028 1.03433156123494 0.785714285714286 17.3 17 3 failure of zygotic cell division 0.00785633278462416 0.0440645497221028 1.03433156123494 0.785714285714286 17.3 17 3 abnormal vascular endothelial cell migration 0.00785633278462416 0.0440645497221028 1.03433156123494 0.785714285714286 17.3 17 3 abnormal sagittal suture morphology 0.00785633278462416 0.0440645497221028 1.03433156123494 0.785714285714286 17.3 17 3 abnormal maternal decidual layer morphology 0.00785633278462416 0.0440645497221028 1.03433156123494 0.785714285714286 17.3 17 3 split sternum 0.00785633278462416 0.0440645497221028 1.03433156123494 0.785714285714286 17.3 17 3 abnormal viscerocranium morphology 0.00785633278462416 0.0440645497221028 1.03433156123494 0.785714285714286 17.3 17 3 increased stomach tumor incidence 0.00785633278462416 0.0440645497221028 1.03433156123494 0.785714285714286 17.3 17 3 pulmonary alveolar hemorrhage 0.00785633278462416 0.0440645497221028 1.03433156123494 0.785714285714286 17.3 17 3 abnormal placenta morphology 1.54628596331623e-10 5.91751743653711e-09 1.0331413062738 0.784810126582278 17.3 17 3 abnormal extraembryonic tissue morphology 3.61338653929177e-13 1.99739978144184e-11 1.0324878329618 0.784313725490196 17.3 17 3 increased lymphocyte cell number 2.85346074912641e-09 9.1586885334864e-08 1.03024329419449 0.782608695652174 17.3 17 3 abnormal cell death 1.29555817755908e-06 2.56788921647666e-05 1.03024329419449 0.782608695652174 17.3 17 3 abnormal regulatory T cell physiology 0.00066491155410537 0.00594952334833492 1.03024329419449 0.782608695652174 17.3 17 3 abnormal hematopoietic stem cell physiology 0.00066491155410537 0.00594952334833492 1.03024329419449 0.782608695652174 17.3 17 3 abnormal vertebral artery topology 0.00066491155410537 0.00594952334833492 1.03024329419449 0.782608695652174 17.3 17 3 abnormal T-helper 2 physiology 1.2543243237566e-07 2.98577201468376e-06 1.02920264440237 0.781818181818182 17.3 17 3 abnormal osteoclast physiology 1.22824587369555e-08 3.59442542449138e-07 1.02845467736429 0.78125 17.3 17 3 abnormal embryonic hematopoiesis 6.03168489209447e-05 0.000742763176687376 1.02845467736429 0.78125 17.3 17 3 thrombocytopenia 1.24682085514502e-17 1.31977313922266e-15 1.02590127264807 0.779310344827586 17.3 17 3 abnormal embryo size 5.16174873593571e-14 3.25059493180761e-12 1.02517818458684 0.778761061946903 17.3 17 3 hydrops fetalis 2.2065763227466e-09 7.12838779588594e-08 1.02388376768711 0.777777777777778 17.3 17 3 axon degeneration 2.28749937480751e-07 5.26866175447564e-06 1.02388376768711 0.777777777777778 17.3 17 3 abnormal atrioventricular cushion morphology 0.000269755562753713 0.00269484723835285 1.02388376768711 0.777777777777778 17.3 17 3 increased brain weight 0.000269755562753713 0.00269484723835285 1.02388376768711 0.777777777777778 17.3 17 3 decreased circulating fructosamine level 0.000269755562753713 0.00269484723835285 1.02388376768711 0.777777777777778 17.3 17 3 decreased bone ossification 0.000269755562753713 0.00269484723835285 1.02388376768711 0.777777777777778 17.3 17 3 abnormal megakaryocyte differentiation 0.00306891213893713 0.0208577020371751 1.02388376768711 0.777777777777778 17.3 17 3 abnormal thymus cortex morphology 0.00306891213893713 0.0208577020371751 1.02388376768711 0.777777777777778 17.3 17 3 abnormal thymus medulla morphology 0.00306891213893713 0.0208577020371751 1.02388376768711 0.777777777777778 17.3 17 3 abnormal neutrophil morphology 0.00306891213893713 0.0208577020371751 1.02388376768711 0.777777777777778 17.3 17 3 abnormal eye anterior chamber morphology 0.00306891213893713 0.0208577020371751 1.02388376768711 0.777777777777778 17.3 17 3 increased susceptibility to autoimmune disorder 0.00306891213893713 0.0208577020371751 1.02388376768711 0.777777777777778 17.3 17 3 decreased lactate dehydrogenase level 0.00306891213893713 0.0208577020371751 1.02388376768711 0.777777777777778 17.3 17 3 small thoracic cage 0.00306891213893713 0.0208577020371751 1.02388376768711 0.777777777777778 17.3 17 3 increased gastrointestinal tumor incidence 0.00306891213893713 0.0208577020371751 1.02388376768711 0.777777777777778 17.3 17 3 decreased tumor latency 0.00306891213893713 0.0208577020371751 1.02388376768711 0.777777777777778 17.3 17 3 increased effector memory CD8-positive, alpha-beta T cell number 0.00306891213893713 0.0208577020371751 1.02388376768711 0.777777777777778 17.3 17 3 increased adipocyte glucose uptake 0.00306891213893713 0.0208577020371751 1.02388376768711 0.777777777777778 17.3 17 3 absent parathyroid glands 0.0391596965340065 0.149630944897605 1.02388376768711 0.777777777777778 17.3 17 3 abnormal cholinergic neuron morphology 0.0391596965340065 0.149630944897605 1.02388376768711 0.777777777777778 17.3 17 3 increased pheochromocytoma incidence 0.0391596965340065 0.149630944897605 1.02388376768711 0.777777777777778 17.3 17 3 polycythemia 0.0391596965340065 0.149630944897605 1.02388376768711 0.777777777777778 17.3 17 3 genetic imprinting 0.0391596965340065 0.149630944897605 1.02388376768711 0.777777777777778 17.3 17 3 abnormal abdominal wall morphology 0.0391596965340065 0.149630944897605 1.02388376768711 0.777777777777778 17.3 17 3 abnormal artery development 0.0391596965340065 0.149630944897605 1.02388376768711 0.777777777777778 17.3 17 3 premature bone ossification 0.0391596965340065 0.149630944897605 1.02388376768711 0.777777777777778 17.3 17 3 short frontal bone 0.0391596965340065 0.149630944897605 1.02388376768711 0.777777777777778 17.3 17 3 liver hyperplasia 0.0391596965340065 0.149630944897605 1.02388376768711 0.777777777777778 17.3 17 3 absent cervical lymph nodes 0.0391596965340065 0.149630944897605 1.02388376768711 0.777777777777778 17.3 17 3 abnormal liver vasculature morphology 0.0391596965340065 0.149630944897605 1.02388376768711 0.777777777777778 17.3 17 3 eye opacity 0.0391596965340065 0.149630944897605 1.02388376768711 0.777777777777778 17.3 17 3 abnormal ventricle myocardium morphology 0.0391596965340065 0.149630944897605 1.02388376768711 0.777777777777778 17.3 17 3 shortened ST segment 0.0391596965340065 0.149630944897605 1.02388376768711 0.777777777777778 17.3 17 3 fusion of atlas and occipital bones 0.0391596965340065 0.149630944897605 1.02388376768711 0.777777777777778 17.3 17 3 increased core body temperature 0.0391596965340065 0.149630944897605 1.02388376768711 0.777777777777778 17.3 17 3 increased myeloid cell number 0.0391596965340065 0.149630944897605 1.02388376768711 0.777777777777778 17.3 17 3 abnormal ductus venosus valve topology 0.0391596965340065 0.149630944897605 1.02388376768711 0.777777777777778 17.3 17 3 abnormal infrahyoid muscle connection 0.0391596965340065 0.149630944897605 1.02388376768711 0.777777777777778 17.3 17 3 abnormal coronary sinus connection 0.0391596965340065 0.149630944897605 1.02388376768711 0.777777777777778 17.3 17 3 preweaning lethality, complete penetrance 1.52575437394556e-83 7.59062801037917e-80 1.02289546289205 0.777027027027027 17.3 17 3 embryonic lethality during organogenesis, complete penetrance 3.00799167903428e-63 3.74118965079889e-60 1.02257779349364 0.776785714285714 17.3 17 3 abnormal spleen morphology 1.81403473185398e-20 3.22315099677626e-18 1.02136188648591 0.775862068965517 17.3 17 3 increased T cell derived lymphoma incidence 9.90343072373766e-07 2.03593255580971e-05 1.02089868381631 0.775510204081633 17.3 17 3 increased lung adenoma incidence 0.000110252725790084 0.00125229979635998 1.01916540931068 0.774193548387097 17.3 17 3 pale kidney 0.000110252725790084 0.00125229979635998 1.01916540931068 0.774193548387097 17.3 17 3 decreased leukocyte cell number 3.13625875206601e-16 2.73734864763656e-14 1.01854547901304 0.773722627737226 17.3 17 3 abnormal astrocyte morphology 4.29887962929822e-06 7.22531289045899e-05 1.01723517179304 0.772727272727273 17.3 17 3 intracerebral hemorrhage 0.00122074938912641 0.00987516782260791 1.01723517179304 0.772727272727273 17.3 17 3 increased skin papilloma incidence 0.00122074938912641 0.00987516782260791 1.01723517179304 0.772727272727273 17.3 17 3 decreased susceptibility to viral infection induced morbidity/mortality 0.00122074938912641 0.00987516782260791 1.01723517179304 0.772727272727273 17.3 17 3 impaired humoral immune response 0.00122074938912641 0.00987516782260791 1.01723517179304 0.772727272727273 17.3 17 3 abnormal somite development 7.16957339445234e-10 2.45990535430348e-08 1.01647773681777 0.772151898734177 17.3 17 3 increased hepatocellular carcinoma incidence 1.74276190029011e-07 4.07053542438653e-06 1.01618539349398 0.771929824561403 17.3 17 3 increased carcinoma incidence 4.53235464967257e-05 0.000576687068596446 1.01552553284885 0.771428571428571 17.3 17 3 holoprosencephaly 4.53235464967257e-05 0.000576687068596446 1.01552553284885 0.771428571428571 17.3 17 3 decreased triglyceride level 4.53235464967257e-05 0.000576687068596446 1.01552553284885 0.771428571428571 17.3 17 3 pale yolk sac 3.03741968058108e-10 1.11111491991845e-08 1.01507237553834 0.771084337349398 17.3 17 3 abnormal neural tube closure 3.03741968058108e-10 1.11111491991845e-08 1.01507237553834 0.771084337349398 17.3 17 3 small heart 1.79294500582459e-06 3.41156483668111e-05 1.01474194833276 0.770833333333333 17.3 17 3 increased osteoclast cell number 7.32663059751117e-08 1.83165764937779e-06 1.0142923506596 0.770491803278688 17.3 17 3 abnormal leukocyte adhesion 1.87188150114916e-05 0.000266836976166679 1.01263229771253 0.769230769230769 17.3 17 3 abnormal erythrocyte osmotic lysis 0.000491695327541785 0.00460675000851296 1.01263229771253 0.769230769230769 17.3 17 3 abnormal Mullerian duct morphology 0.000491695327541785 0.00460675000851296 1.01263229771253 0.769230769230769 17.3 17 3 increased foot pad pigmentation 0.0145581758615623 0.0736045984870655 1.01263229771253 0.769230769230769 17.3 17 3 increased pituitary adenoma incidence 0.0145581758615623 0.0736045984870655 1.01263229771253 0.769230769230769 17.3 17 3 lymphoid hypoplasia 0.0145581758615623 0.0736045984870655 1.01263229771253 0.769230769230769 17.3 17 3 abnormal exocrine pancreas morphology 0.0145581758615623 0.0736045984870655 1.01263229771253 0.769230769230769 17.3 17 3 increased prostaglandin level 0.0145581758615623 0.0736045984870655 1.01263229771253 0.769230769230769 17.3 17 3 abnormal aorta tunica media morphology 0.0145581758615623 0.0736045984870655 1.01263229771253 0.769230769230769 17.3 17 3 microcephaly 1.2994953344835e-08 3.77110344130739e-07 1.01116471467237 0.768115942028985 17.3 17 3 decreased circulating serum albumin level 9.82429629792877e-12 4.52554389649959e-10 1.01058657589897 0.767676767676768 17.3 17 3 arrested T cell differentiation 0.000199864579323687 0.00208892076078853 1.00925685672015 0.766666666666667 17.3 17 3 salivary gland inflammation 0.000199864579323687 0.00208892076078853 1.00925685672015 0.766666666666667 17.3 17 3 abnormal optic cup morphology 0.000199864579323687 0.00208892076078853 1.00925685672015 0.766666666666667 17.3 17 3 abnormal brain vasculature morphology 0.000199864579323687 0.00208892076078853 1.00925685672015 0.766666666666667 17.3 17 3 abnormal immune system physiology 3.22945382752959e-14 2.08656270025451e-12 1.00854910296369 0.766129032258065 17.3 17 3 increased respiratory quotient 3.2275499505654e-06 5.65389471974045e-05 1.00832322410524 0.765957446808511 17.3 17 3 pallor 2.00736597427081e-19 2.69909343837764e-17 1.00800312149442 0.765714285714286 17.3 17 3 increased neutrophil cell number 2.52068655387881e-16 2.23935992956198e-14 1.00774372799943 0.76551724137931 17.3 17 3 abnormal vitelline vasculature morphology 3.19329079467137e-13 1.80529792085114e-11 1.00734899876794 0.765217391304348 17.3 17 3 abnormal embryo development 2.48460578808137e-15 2.05478564346775e-13 1.00667563713775 0.764705882352941 17.3 17 3 abnormal gastrulation 1.34592231912813e-06 2.62586805398528e-05 1.00667563713775 0.764705882352941 17.3 17 3 failure of chorioallantoic fusion 1.34592231912813e-06 2.62586805398528e-05 1.00667563713775 0.764705882352941 17.3 17 3 decreased cytotoxic T cell cytolysis 8.1809669940144e-05 0.000962182288303113 1.00667563713775 0.764705882352941 17.3 17 3 abnormal interatrial septum morphology 0.0056172347195234 0.0351366302386253 1.00667563713775 0.764705882352941 17.3 17 3 decreased vasoconstriction 0.0056172347195234 0.0351366302386253 1.00667563713775 0.764705882352941 17.3 17 3 abnormal embryonic-extraembryonic boundary morphology 0.0056172347195234 0.0351366302386253 1.00667563713775 0.764705882352941 17.3 17 3 enhanced behavioral response to cocaine 0.0056172347195234 0.0351366302386253 1.00667563713775 0.764705882352941 17.3 17 3 abnormal circulating chemokine level 0.0056172347195234 0.0351366302386253 1.00667563713775 0.764705882352941 17.3 17 3 abnormal inflammatory response 9.80422532811634e-09 2.93831451851679e-07 1.00560012897842 0.763888888888889 17.3 17 3 decreased circulating total protein level 5.62544953974127e-07 1.22748295878126e-05 1.00526769918371 0.763636363636364 17.3 17 3 persistence of hyaloid vascular system 3.36711407612424e-05 0.00044789819595503 1.00463783220427 0.763157894736842 17.3 17 3 abnormal spleen white pulp morphology 1.39198231648936e-05 0.000204884971140076 1.00298818059146 0.761904761904762 17.3 17 3 abnormal anxiety-related response 0.00221612048517168 0.0162135285496016 1.00298818059146 0.761904761904762 17.3 17 3 left pulmonary isomerism 0.00221612048517168 0.0162135285496016 1.00298818059146 0.761904761904762 17.3 17 3 increased muscle cell glucose uptake 0.00221612048517168 0.0162135285496016 1.00298818059146 0.761904761904762 17.3 17 3 increased spleen weight 1.01249650977034e-12 5.4163119743091e-11 1.00187868039169 0.761061946902655 17.3 17 3 abnormal immune system morphology 5.77550460369921e-06 9.51428324616011e-05 1.00162542491131 0.760869565217391 17.3 17 3 abnormal primitive streak morphology 0.000887371843902847 0.00748249987019774 1.00048071013998 0.76 17.3 17 3 lethality throughout fetal growth and development, incomplete penetrance 3.64562218796764e-19 4.65050522695871e-17 1.00018653762891 0.759776536312849 17.3 17 3 abnormal placenta labyrinth morphology 3.10113664835234e-09 9.88984283689288e-08 0.999814167361738 0.759493670886076 17.3 17 3 neurodegeneration 1.00289655543682e-06 2.036494025836e-05 0.999505582742182 0.759259259259259 17.3 17 3 decreased tumor growth/size 1.00289655543682e-06 2.036494025836e-05 0.999505582742182 0.759259259259259 17.3 17 3 abnormal cell adhesion 1.00289655543682e-06 2.036494025836e-05 0.999505582742182 0.759259259259259 17.3 17 3 decreased hemoglobin content 2.5194356633474e-15 2.05478564346775e-13 0.99898689795612 0.75886524822695 17.3 17 3 abnormal embryonic neuroepithelium morphology 4.19372612019925e-07 9.35595849685708e-06 0.998664955675116 0.758620689655172 17.3 17 3 thrombocytosis 4.19372612019925e-07 9.35595849685708e-06 0.998664955675116 0.758620689655172 17.3 17 3 decreased bone strength 0.00035910685921236 0.00343568581650286 0.998664955675116 0.758620689655172 17.3 17 3 lethality throughout fetal growth and development, complete penetrance 4.96561187898821e-20 7.96900616063431e-18 0.997709295430451 0.757894736842105 17.3 17 3 abnormal aorta morphology 0.000146486146183272 0.00161400938128829 0.997289384110825 0.757575757575758 17.3 17 3 increased cardiomyocyte apoptosis 0.000146486146183272 0.00161400938128829 0.997289384110825 0.757575757575758 17.3 17 3 abnormal angiogenesis 1.3037784761907e-08 3.77110344130739e-07 0.9962112334253 0.756756756756757 17.3 17 3 skin inflammation 6.01247668568948e-05 0.00074223502509442 0.9962112334253 0.756756756756757 17.3 17 3 abnormal myocardial trabeculae morphology 1.02706084576454e-05 0.000154893738996216 0.994629945753196 0.755555555555556 17.3 17 3 abnormal cell migration 1.02706084576454e-05 0.000154893738996216 0.994629945753196 0.755555555555556 17.3 17 3 pericardial edema 9.6244208439336e-08 2.33568261944242e-06 0.987316490269717 0.75 17.3 17 3 decreased mean corpuscular hemoglobin 9.6244208439336e-08 2.33568261944242e-06 0.987316490269717 0.75 17.3 17 3 kinked neural tube 3.13526987629126e-06 5.57070272662464e-05 0.987316490269717 0.75 17.3 17 3 increased bone resorption 0.000639103312114967 0.00577048816292552 0.987316490269717 0.75 17.3 17 3 failure of tooth eruption 0.0101327241194664 0.0550330813257044 0.987316490269717 0.75 17.3 17 3 abnormal bone marrow cell number 0.0101327241194664 0.0550330813257044 0.987316490269717 0.75 17.3 17 3 abnormal olfaction 0.0101327241194664 0.0550330813257044 0.987316490269717 0.75 17.3 17 3 increased intestinal adenocarcinoma incidence 0.0101327241194664 0.0550330813257044 0.987316490269717 0.75 17.3 17 3 large intestinal inflammation 0.0101327241194664 0.0550330813257044 0.987316490269717 0.75 17.3 17 3 abnormal amnion morphology 0.0101327241194664 0.0550330813257044 0.987316490269717 0.75 17.3 17 3 sepsis 0.0101327241194664 0.0550330813257044 0.987316490269717 0.75 17.3 17 3 blepharitis 0.0101327241194664 0.0550330813257044 0.987316490269717 0.75 17.3 17 3 dystonia 0.0101327241194664 0.0550330813257044 0.987316490269717 0.75 17.3 17 3 kidney degeneration 0.0101327241194664 0.0550330813257044 0.987316490269717 0.75 17.3 17 3 abnormal ear pigmentation 0.0724205014898839 0.238603970140511 0.987316490269717 0.75 17.3 17 3 abnormal bone marrow development 0.0724205014898839 0.238603970140511 0.987316490269717 0.75 17.3 17 3 schistocytosis 0.0724205014898839 0.238603970140511 0.987316490269717 0.75 17.3 17 3 abnormal cecum morphology 0.0724205014898839 0.238603970140511 0.987316490269717 0.75 17.3 17 3 enlarged pituitary gland 0.0724205014898839 0.238603970140511 0.987316490269717 0.75 17.3 17 3 abnormal vagus ganglion morphology 0.0724205014898839 0.238603970140511 0.987316490269717 0.75 17.3 17 3 abnormal atrial thrombosis 0.0724205014898839 0.238603970140511 0.987316490269717 0.75 17.3 17 3 abnormal hepatobiliary system morphology 0.0724205014898839 0.238603970140511 0.987316490269717 0.75 17.3 17 3 head spot 0.0724205014898839 0.238603970140511 0.987316490269717 0.75 17.3 17 3 hypospadia 0.0724205014898839 0.238603970140511 0.987316490269717 0.75 17.3 17 3 absent tympanic ring 0.0724205014898839 0.238603970140511 0.987316490269717 0.75 17.3 17 3 abnormal soft palate morphology 0.0724205014898839 0.238603970140511 0.987316490269717 0.75 17.3 17 3 colon polyps 0.0724205014898839 0.238603970140511 0.987316490269717 0.75 17.3 17 3 increased cardiac output 0.0724205014898839 0.238603970140511 0.987316490269717 0.75 17.3 17 3 pulmonary interstitial fibrosis 0.0724205014898839 0.238603970140511 0.987316490269717 0.75 17.3 17 3 abnormal eyelid aperture 0.0724205014898839 0.238603970140511 0.987316490269717 0.75 17.3 17 3 binucleate 0.0724205014898839 0.238603970140511 0.987316490269717 0.75 17.3 17 3 abnormal extraembryonic tissue physiology 0.0724205014898839 0.238603970140511 0.987316490269717 0.75 17.3 17 3 small frontal bone 0.0724205014898839 0.238603970140511 0.987316490269717 0.75 17.3 17 3 absent interparietal bone 0.0724205014898839 0.238603970140511 0.987316490269717 0.75 17.3 17 3 abnormal kidney epithelium morphology 0.0724205014898839 0.238603970140511 0.987316490269717 0.75 17.3 17 3 abnormal somite size 0.0724205014898839 0.238603970140511 0.987316490269717 0.75 17.3 17 3 abnormal ilium morphology 0.0724205014898839 0.238603970140511 0.987316490269717 0.75 17.3 17 3 abnormal thymus epithelium morphology 0.0724205014898839 0.238603970140511 0.987316490269717 0.75 17.3 17 3 abnormal frontonasal prominence morphology 0.0724205014898839 0.238603970140511 0.987316490269717 0.75 17.3 17 3 skin fibrosis 0.0724205014898839 0.238603970140511 0.987316490269717 0.75 17.3 17 3 abnormal olfactory bulb glomerular layer morphology 0.0724205014898839 0.238603970140511 0.987316490269717 0.75 17.3 17 3 decreased hippocampus pyramidal cell number 0.0724205014898839 0.238603970140511 0.987316490269717 0.75 17.3 17 3 increased caudal vertebrae number 0.0724205014898839 0.238603970140511 0.987316490269717 0.75 17.3 17 3 abnormal circulating serum amyloid protein level 0.0724205014898839 0.238603970140511 0.987316490269717 0.75 17.3 17 3 decreased alveolar lamellar body number 0.0724205014898839 0.238603970140511 0.987316490269717 0.75 17.3 17 3 abnormal maxillary prominence morphology 0.0724205014898839 0.238603970140511 0.987316490269717 0.75 17.3 17 3 increased aorta wall thickness 0.0724205014898839 0.238603970140511 0.987316490269717 0.75 17.3 17 3 abnormal macrophage activation involved in immune response 0.0724205014898839 0.238603970140511 0.987316490269717 0.75 17.3 17 3 prolonged PQ interval 0.0724205014898839 0.238603970140511 0.987316490269717 0.75 17.3 17 3 increased cornea thickness 0.0724205014898839 0.238603970140511 0.987316490269717 0.75 17.3 17 3 small thymus medulla 0.0724205014898839 0.238603970140511 0.987316490269717 0.75 17.3 17 3 absent hypoglossal canal 0.0724205014898839 0.238603970140511 0.987316490269717 0.75 17.3 17 3 retropleural edema 0.0724205014898839 0.238603970140511 0.987316490269717 0.75 17.3 17 3 increased mammary gland apoptosis 0.0724205014898839 0.238603970140511 0.987316490269717 0.75 17.3 17 3 decreased white adipose tissue mass 0.0724205014898839 0.238603970140511 0.987316490269717 0.75 17.3 17 3 decreased basal metabolism 0.0724205014898839 0.238603970140511 0.987316490269717 0.75 17.3 17 3 overriding aortic valve 7.53136478478766e-06 0.000117456237631093 0.987316490269717 0.75 17.3 17 3 thymus atrophy 7.53136478478766e-06 0.000117456237631093 0.987316490269717 0.75 17.3 17 3 small lymph nodes 0.00158429596049367 0.0121446416077905 0.987316490269717 0.75 17.3 17 3 abnormal cell proliferation 0.00397355647875162 0.0259428392149466 0.987316490269717 0.75 17.3 17 3 small gonad 0.00397355647875162 0.0259428392149466 0.987316490269717 0.75 17.3 17 3 abnormal circulating enzyme level 0.00397355647875162 0.0259428392149466 0.987316490269717 0.75 17.3 17 3 anencephaly 0.00397355647875162 0.0259428392149466 0.987316490269717 0.75 17.3 17 3 abnormal Peyer's patch T cell area morphology 0.00397355647875162 0.0259428392149466 0.987316490269717 0.75 17.3 17 3 dilated vasculature 0.00397355647875162 0.0259428392149466 0.987316490269717 0.75 17.3 17 3 kidney atrophy 0.00397355647875162 0.0259428392149466 0.987316490269717 0.75 17.3 17 3 abnormal induced retinal neovascularization 0.00397355647875162 0.0259428392149466 0.987316490269717 0.75 17.3 17 3 abnormal sperm mitochondrial sheath morphology 0.00397355647875162 0.0259428392149466 0.987316490269717 0.75 17.3 17 3 abnormal supraoccipital bone morphology 0.0265027067643966 0.116373315227602 0.987316490269717 0.75 17.3 17 3 amyloidosis 0.0265027067643966 0.116373315227602 0.987316490269717 0.75 17.3 17 3 interstitial pneumonia 0.0265027067643966 0.116373315227602 0.987316490269717 0.75 17.3 17 3 abnormal embryonic growth/weight/body size 0.0265027067643966 0.116373315227602 0.987316490269717 0.75 17.3 17 3 abnormal respiratory function 0.0265027067643966 0.116373315227602 0.987316490269717 0.75 17.3 17 3 decreased synaptic depression 0.0265027067643966 0.116373315227602 0.987316490269717 0.75 17.3 17 3 abnormal defecation 0.0265027067643966 0.116373315227602 0.987316490269717 0.75 17.3 17 3 abnormal rostral-caudal body axis extension 0.0265027067643966 0.116373315227602 0.987316490269717 0.75 17.3 17 3 pale placenta 0.0265027067643966 0.116373315227602 0.987316490269717 0.75 17.3 17 3 bowed ulna 0.0265027067643966 0.116373315227602 0.987316490269717 0.75 17.3 17 3 hematuria 0.0265027067643966 0.116373315227602 0.987316490269717 0.75 17.3 17 3 abnormal fatty acid level 0.0265027067643966 0.116373315227602 0.987316490269717 0.75 17.3 17 3 decreased prostaglandin level 0.0265027067643966 0.116373315227602 0.987316490269717 0.75 17.3 17 3 decreased mammary gland epithelial cell proliferation 0.0265027067643966 0.116373315227602 0.987316490269717 0.75 17.3 17 3 embryonic lethality between implantation and placentation, incomplete penetrance 0.0265027067643966 0.116373315227602 0.987316490269717 0.75 17.3 17 3 abnormal colon goblet cell morphology 0.0265027067643966 0.116373315227602 0.987316490269717 0.75 17.3 17 3 abnormal hepatocyte morphology 1.2790007851016e-11 5.83764119805546e-10 0.984351575884522 0.747747747747748 17.3 17 3 abnormal craniofacial morphology 7.13168377018076e-11 2.93224188071482e-09 0.98412129127208 0.747572815533981 17.3 17 3 gliosis 4.01505054112722e-07 9.03840562991308e-06 0.982092593495803 0.746031746031746 17.3 17 3 decreased susceptibility to hepatic steatosis 4.01505054112722e-07 9.03840562991308e-06 0.982092593495803 0.746031746031746 17.3 17 3 abnormal trophoblast layer morphology 5.49534176212026e-06 9.08283231446787e-05 0.980863441313706 0.745098039215686 17.3 17 3 increased oxygen consumption 3.88974316442281e-09 1.23257784987283e-07 0.979662874066075 0.744186046511628 17.3 17 3 abnormal vasculogenesis 3.18379843307633e-05 0.000428091816339318 0.979662874066075 0.744186046511628 17.3 17 3 abnormal left-right axis patterning 3.18379843307633e-05 0.000428091816339318 0.979662874066075 0.744186046511628 17.3 17 3 delayed endochondral bone ossification 3.18379843307633e-05 0.000428091816339318 0.979662874066075 0.744186046511628 17.3 17 3 spleen hypoplasia 9.14389052943377e-11 3.7287586380273e-09 0.977913476076672 0.742857142857143 17.3 17 3 abnormal liver development 0.000187214026554465 0.00199441066832647 0.977913476076672 0.742857142857143 17.3 17 3 increased circulating serum albumin level 0.000187214026554465 0.00199441066832647 0.977913476076672 0.742857142857143 17.3 17 3 decreased glycogen level 0.000187214026554465 0.00199441066832647 0.977913476076672 0.742857142857143 17.3 17 3 decreased bone mineralization 0.000187214026554465 0.00199441066832647 0.977913476076672 0.742857142857143 17.3 17 3 increased eosinophil cell number 6.99452095076454e-07 1.48708297991682e-05 0.97670018392273 0.741935483870968 17.3 17 3 pericardial effusion 6.99452095076454e-07 1.48708297991682e-05 0.97670018392273 0.741935483870968 17.3 17 3 abnormal podocyte morphology 0.000457498658232793 0.00435192318299837 0.97670018392273 0.741935483870968 17.3 17 3 decreased platelet aggregation 3.99357028949666e-06 6.80411376378283e-05 0.975127397797251 0.740740740740741 17.3 17 3 abnormal brain commissure morphology 0.00112580894122198 0.00938174117684984 0.975127397797251 0.740740740740741 17.3 17 3 abnormal eye muscle morphology 0.00112580894122198 0.00938174117684984 0.975127397797251 0.740740740740741 17.3 17 3 decreased oocyte number 9.57291296883225e-06 0.000146539206215201 0.974152270399454 0.74 17.3 17 3 seminiferous tubule degeneration 9.00098227191926e-08 2.21682607934645e-06 0.973791606841364 0.73972602739726 17.3 17 3 abnormal allantois morphology 2.30067360438263e-05 0.000321512673646169 0.973007555628126 0.739130434782609 17.3 17 3 failure of embryo implantation 0.00279562325501936 0.0193707878742637 0.973007555628126 0.739130434782609 17.3 17 3 pancreas inflammation 0.00279562325501936 0.0193707878742637 0.973007555628126 0.739130434782609 17.3 17 3 increased susceptibility to fungal infection 0.00279562325501936 0.0193707878742637 0.973007555628126 0.739130434782609 17.3 17 3 decreased effector memory CD8-positive, alpha-beta T cell number 0.00279562325501936 0.0193707878742637 0.973007555628126 0.739130434782609 17.3 17 3 prenatal lethality, complete penetrance 3.08486538305719e-25 7.67360264035477e-23 0.970742832159673 0.737410071942446 17.3 17 3 increased mean corpuscular hemoglobin 6.45143446674651e-10 2.26027369521577e-08 0.970695000534536 0.737373737373737 17.3 17 3 decreased birth body size 3.59453414685544e-11 1.52844507526545e-09 0.96999514833516 0.736842105263158 17.3 17 3 increased bone marrow cell number 0.000134194919924722 0.00150364803294029 0.96999514833516 0.736842105263158 17.3 17 3 decreased hair follicle number 0.000134194919924722 0.00150364803294029 0.96999514833516 0.736842105263158 17.3 17 3 incomplete somite formation 0.000134194919924722 0.00150364803294029 0.96999514833516 0.736842105263158 17.3 17 3 kyphoscoliosis 0.00702789879607446 0.0402808715558415 0.96999514833516 0.736842105263158 17.3 17 3 irregular coat pigmentation 0.00702789879607446 0.0402808715558415 0.96999514833516 0.736842105263158 17.3 17 3 abnormal stationary movement 0.00702789879607446 0.0402808715558415 0.96999514833516 0.736842105263158 17.3 17 3 increased malignant tumor incidence 0.00702789879607446 0.0402808715558415 0.96999514833516 0.736842105263158 17.3 17 3 abnormal nasal septum morphology 0.00702789879607446 0.0402808715558415 0.96999514833516 0.736842105263158 17.3 17 3 abnormal digestive system development 0.00702789879607446 0.0402808715558415 0.96999514833516 0.736842105263158 17.3 17 3 absent amnion 0.00702789879607446 0.0402808715558415 0.96999514833516 0.736842105263158 17.3 17 3 decreased susceptibility to weight gain 0.00702789879607446 0.0402808715558415 0.96999514833516 0.736842105263158 17.3 17 3 shortened RR interval 0.00702789879607446 0.0402808715558415 0.96999514833516 0.736842105263158 17.3 17 3 abnormal placenta development 6.91552166851708e-06 0.000110982968712492 0.96868787724576 0.735849056603774 17.3 17 3 abnormal embryonic tissue morphology 8.27712922159879e-14 5.14733973468175e-12 0.967167174141763 0.73469387755102 17.3 17 3 increased circulating alkaline phosphatase level 4.66946871753214e-15 3.68739791582895e-13 0.96700133614894 0.734567901234568 17.3 17 3 abnormal heart development 1.09607698548492e-14 7.7899757182678e-13 0.96648702844968 0.734177215189873 17.3 17 3 increased bone mineral content 1.45399031418714e-10 5.60744326595428e-09 0.96618127488168 0.73394495412844 17.3 17 3 oxidative stress 6.17857636200392e-09 1.88579247858709e-07 0.965376123819279 0.733333333333333 17.3 17 3 albuminuria 3.98002598737569e-05 0.000516987709848409 0.965376123819279 0.733333333333333 17.3 17 3 increased erythrocyte cell number 2.08933759033957e-06 3.86189243847906e-05 0.965376123819278 0.733333333333333 17.3 17 3 increased metastatic potential 0.000797023128906209 0.00681304135104534 0.965376123819278 0.733333333333333 17.3 17 3 abnormal cellular respiration 0.000797023128906209 0.00681304135104534 0.965376123819278 0.733333333333333 17.3 17 3 abnormal fontanelle morphology 0.0179797523366284 0.0858438271350539 0.965376123819278 0.733333333333333 17.3 17 3 hyperpigmentation 0.0179797523366284 0.0858438271350539 0.965376123819278 0.733333333333333 17.3 17 3 increased airway responsiveness 0.0179797523366284 0.0858438271350539 0.965376123819278 0.733333333333333 17.3 17 3 joint inflammation 0.0179797523366284 0.0858438271350539 0.965376123819278 0.733333333333333 17.3 17 3 abnormal energy homeostasis 0.0179797523366284 0.0858438271350539 0.965376123819278 0.733333333333333 17.3 17 3 liver vascular congestion 0.0179797523366284 0.0858438271350539 0.965376123819278 0.733333333333333 17.3 17 3 bicuspid aortic valve 0.0179797523366284 0.0858438271350539 0.965376123819278 0.733333333333333 17.3 17 3 herniated liver 0.0179797523366284 0.0858438271350539 0.965376123819278 0.733333333333333 17.3 17 3 decreased brown adipose tissue mass 0.0179797523366284 0.0858438271350539 0.965376123819278 0.733333333333333 17.3 17 3 increased tumor growth/size 9.58867955996393e-05 0.00110681393992623 0.963235600263138 0.731707317073171 17.3 17 3 increased bone trabecula number 9.58867955996393e-05 0.00110681393992623 0.963235600263138 0.731707317073171 17.3 17 3 lethality at weaning, incomplete penetrance 9.58867955996393e-05 0.00110681393992623 0.963235600263138 0.731707317073171 17.3 17 3 decreased white adipose tissue amount 6.3383404675753e-07 1.3591915442322e-05 0.962756378571465 0.73134328358209 17.3 17 3 decreased circulating glycerol level 0.00196135095974003 0.0145637627234428 0.962000682826903 0.730769230769231 17.3 17 3 pulmonary edema 0.00196135095974003 0.0145637627234428 0.962000682826903 0.730769230769231 17.3 17 3 increased rib number 8.15334136181205e-08 2.02814366375075e-06 0.962000682826903 0.730769230769231 17.3 17 3 decreased rib number 1.05712397738468e-08 3.1119478032478e-07 0.961431788277627 0.730337078651685 17.3 17 3 increased trabecular bone volume 0.000231831927686655 0.00237317662601051 0.960632260802967 0.72972972972973 17.3 17 3 embryonic growth arrest 5.39601588463576e-20 8.38911844564465e-18 0.960010794032272 0.729257641921397 17.3 17 3 abnormal osteoclast morphology 2.84877003806714e-05 0.00038935799284022 0.959891032206669 0.729166666666667 17.3 17 3 abnormal thoracic vertebrae morphology 3.58116236187971e-06 6.20776402451274e-05 0.959426193934414 0.728813559322034 17.3 17 3 preweaning lethality, incomplete penetrance 1.95242137495413e-34 8.83026940036072e-32 0.959153428200083 0.728606356968215 17.3 17 3 abnormal neural tube morphology 1.69180816054652e-14 1.12223274649586e-12 0.95887527450063 0.728395061728395 17.3 17 3 lung inflammation 2.26835675841969e-12 1.12850748731379e-10 0.958277769967666 0.727941176470588 17.3 17 3 hemorrhage 2.84803092543318e-20 4.72298461801003e-18 0.95790706289998 0.727659574468085 17.3 17 3 lethality, incomplete penetrance 6.83521234298434e-05 0.00082939466844749 0.957397808746392 0.727272727272727 17.3 17 3 abnormal abdominal fat pad morphology 0.00487044340795904 0.0312651044575435 0.957397808746392 0.727272727272727 17.3 17 3 intestinal inflammation 0.00487044340795904 0.0312651044575435 0.957397808746392 0.727272727272727 17.3 17 3 abnormal limb posture 0.00487044340795904 0.0312651044575435 0.957397808746392 0.727272727272727 17.3 17 3 abnormal blood-brain barrier function 0.00487044340795904 0.0312651044575435 0.957397808746392 0.727272727272727 17.3 17 3 abnormal cerebral cortex pyramidal cell morphology 0.00487044340795904 0.0312651044575435 0.957397808746392 0.727272727272727 17.3 17 3 abnormal sebaceous gland morphology 0.0472581347197623 0.174542850950867 0.957397808746392 0.727272727272727 17.3 17 3 abnormal eye distance/ position 0.0472581347197623 0.174542850950867 0.957397808746392 0.727272727272727 17.3 17 3 abnormal food preference 0.0472581347197623 0.174542850950867 0.957397808746392 0.727272727272727 17.3 17 3 failure of somite differentiation 0.0472581347197623 0.174542850950867 0.957397808746392 0.727272727272727 17.3 17 3 abnormal proximal-distal axis patterning 0.0472581347197623 0.174542850950867 0.957397808746392 0.727272727272727 17.3 17 3 abnormal fear/anxiety-related behavior 0.0472581347197623 0.174542850950867 0.957397808746392 0.727272727272727 17.3 17 3 abnormal bronchiole morphology 0.0472581347197623 0.174542850950867 0.957397808746392 0.727272727272727 17.3 17 3 abnormal coronal suture morphology 0.0472581347197623 0.174542850950867 0.957397808746392 0.727272727272727 17.3 17 3 pharyngeal arch hypoplasia 0.0472581347197623 0.174542850950867 0.957397808746392 0.727272727272727 17.3 17 3 abnormal spinal cord ventral horn morphology 0.0472581347197623 0.174542850950867 0.957397808746392 0.727272727272727 17.3 17 3 abnormal palate development 0.0472581347197623 0.174542850950867 0.957397808746392 0.727272727272727 17.3 17 3 increased number of Howell-Jolly bodies 0.0472581347197623 0.174542850950867 0.957397808746392 0.727272727272727 17.3 17 3 aorta dilation 0.0472581347197623 0.174542850950867 0.957397808746392 0.727272727272727 17.3 17 3 abnormal pulmonary alveolar sac morphology 0.0472581347197623 0.174542850950867 0.957397808746392 0.727272727272727 17.3 17 3 chylous ascites 0.0472581347197623 0.174542850950867 0.957397808746392 0.727272727272727 17.3 17 3 enlarged pericardium 0.000562924916968792 0.00523467562975653 0.957397808746392 0.727272727272727 17.3 17 3 abnormal locomotor coordination 0.000562924916968792 0.00523467562975653 0.957397808746392 0.727272727272727 17.3 17 3 reduced fertility 1.64376620187102e-12 8.5184758899045e-11 0.956536839493922 0.726618705035971 17.3 17 3 abnormal cervical vertebrae morphology 2.03493511579996e-05 0.000287608017076841 0.955051245489661 0.725490196078431 17.3 17 3 abnormal spermiogenesis 6.10257109632e-06 9.95419383744e-05 0.953271094053519 0.724137931034483 17.3 17 3 abnormal parietal bone morphology 0.00137409400098431 0.0108831400537254 0.953271094053519 0.724137931034483 17.3 17 3 lordosis 0.00137409400098431 0.0108831400537254 0.953271094053519 0.724137931034483 17.3 17 3 decreased trophoblast giant cell number 0.00137409400098431 0.0108831400537254 0.953271094053519 0.724137931034483 17.3 17 3 increased susceptibility to induced arthritis 0.00137409400098431 0.0108831400537254 0.953271094053519 0.724137931034483 17.3 17 3 abnormal embryonic erythropoiesis 0.00137409400098431 0.0108831400537254 0.953271094053519 0.724137931034483 17.3 17 3 neuron degeneration 4.86367129049969e-05 0.000611029410864545 0.952305267210507 0.723404255319149 17.3 17 3 decreased bone trabecula number 4.86367129049969e-05 0.000611029410864545 0.952305267210507 0.723404255319149 17.3 17 3 lowered ear position 0.0122428734290477 0.0646584875897159 0.95074921285232 0.722222222222222 17.3 17 3 cortical renal glomerulopathies 0.0122428734290477 0.0646584875897159 0.95074921285232 0.722222222222222 17.3 17 3 abnormal white adipose tissue morphology 0.0122428734290477 0.0646584875897159 0.95074921285232 0.722222222222222 17.3 17 3 abnormal body wall morphology 0.0122428734290477 0.0646584875897159 0.95074921285232 0.722222222222222 17.3 17 3 primary atelectasis 0.0122428734290477 0.0646584875897159 0.95074921285232 0.722222222222222 17.3 17 3 increased effector memory CD4-positive, alpha-beta T cell number 0.0122428734290477 0.0646584875897159 0.95074921285232 0.722222222222222 17.3 17 3 edema 1.32717605013651e-14 9.17041784642933e-13 0.949048409251511 0.720930232558139 17.3 17 3 abnormal interventricular septum morphology 3.45603225943959e-05 0.000456067917525516 0.947823830658928 0.72 17.3 17 3 decreased circulating alkaline phosphatase level 3.45603225943959e-05 0.000456067917525516 0.947823830658928 0.72 17.3 17 3 abnormal egg cylinder morphology 0.00337638654601295 0.0225470108274019 0.947823830658928 0.72 17.3 17 3 abnormal cochlear outer hair cell morphology 0.00337638654601295 0.0225470108274019 0.947823830658928 0.72 17.3 17 3 abnormal preimplantation embryo development 0.00337638654601295 0.0225470108274019 0.947823830658928 0.72 17.3 17 3 absent vitelline blood vessels 1.03366274063807e-05 0.000154893738996216 0.946900025755752 0.719298245614035 17.3 17 3 abnormal craniofacial bone morphology 1.03366274063807e-05 0.000154893738996216 0.946900025755752 0.719298245614035 17.3 17 3 increased macrophage cell number 1.03366274063807e-05 0.000154893738996216 0.946900025755752 0.719298245614035 17.3 17 3 abnormal bone mineralization 1.40355097425887e-10 5.45520788823271e-09 0.946518288192456 0.71900826446281 17.3 17 3 abnormal vertebral body morphology 0.000962063207367419 0.00808490617677856 0.946178303175145 0.71875 17.3 17 3 abnormal heart looping 0.000279698280442687 0.00277191024940711 0.945123477865028 0.717948717948718 17.3 17 3 increased hepatocyte apoptosis 0.000279698280442687 0.00277191024940711 0.945123477865028 0.717948717948718 17.3 17 3 abnormal response to injury 0.000279698280442687 0.00277191024940711 0.945123477865028 0.717948717948718 17.3 17 3 abnormal locomotor behavior 2.65663128559525e-08 7.18301122056324e-07 0.944389686344946 0.717391304347826 17.3 17 3 abnormal sleep pattern 8.24299742112734e-05 0.000962650520425083 0.944389686344946 0.717391304347826 17.3 17 3 failure to gastrulate 8.24299742112734e-05 0.000962650520425083 0.944389686344946 0.717391304347826 17.3 17 3 abnormal myelin sheath morphology 8.24299742112734e-05 0.000962650520425083 0.944389686344946 0.717391304347826 17.3 17 3 abnormal mesoderm development 2.45317658947705e-05 0.000340909316554423 0.943849726547151 0.716981132075472 17.3 17 3 liver inflammation 2.35384851689345e-10 8.87151240268552e-09 0.94343575736884 0.716666666666667 17.3 17 3 absent mesoderm 7.35460148989301e-06 0.00011631960570171 0.94343575736884 0.716666666666667 17.3 17 3 muscular ventricular septal defect 7.35460148989301e-06 0.00011631960570171 0.94343575736884 0.716666666666667 17.3 17 3 rib fusion 2.21745809541236e-06 4.01158328170055e-05 0.943108289212864 0.716417910447761 17.3 17 3 internal hemorrhage 2.21745809541236e-06 4.01158328170055e-05 0.943108289212864 0.716417910447761 17.3 17 3 kinked tail 5.8251985048759e-09 1.80002251936383e-07 0.942145147577638 0.715686274509804 17.3 17 3 failure of blastocyst to hatch from the zona pellucida 0.00234257301398952 0.0170884175140731 0.940301419304492 0.714285714285714 17.3 17 3 increased triglyceride level 0.00234257301398952 0.0170884175140731 0.940301419304492 0.714285714285714 17.3 17 3 megacephaly 0.0313127835539076 0.131906094987883 0.940301419304492 0.714285714285714 17.3 17 3 increased aggression towards males 0.0313127835539076 0.131906094987883 0.940301419304492 0.714285714285714 17.3 17 3 absent visceral yolk sac blood islands 0.0313127835539076 0.131906094987883 0.940301419304492 0.714285714285714 17.3 17 3 abnormal adrenal gland secretion 0.0313127835539076 0.131906094987883 0.940301419304492 0.714285714285714 17.3 17 3 increased lactate dehydrogenase level 0.0313127835539076 0.131906094987883 0.940301419304492 0.714285714285714 17.3 17 3 absent olfactory bulb 0.0313127835539076 0.131906094987883 0.940301419304492 0.714285714285714 17.3 17 3 spina bifida occulta 0.0313127835539076 0.131906094987883 0.940301419304492 0.714285714285714 17.3 17 3 increased pulmonary respiratory rate 0.0313127835539076 0.131906094987883 0.940301419304492 0.714285714285714 17.3 17 3 decreased compact bone area 0.0313127835539076 0.131906094987883 0.940301419304492 0.714285714285714 17.3 17 3 mammary gland hyperplasia 0.130211150100721 0.355348585710963 0.940301419304492 0.714285714285714 17.3 17 3 abnormal oculomotor nerve morphology 0.130211150100721 0.355348585710963 0.940301419304492 0.714285714285714 17.3 17 3 decreased Schwann cell number 0.130211150100721 0.355348585710963 0.940301419304492 0.714285714285714 17.3 17 3 prostate gland epithelial hyperplasia 0.130211150100721 0.355348585710963 0.940301419304492 0.714285714285714 17.3 17 3 retina hyperplasia 0.130211150100721 0.355348585710963 0.940301419304492 0.714285714285714 17.3 17 3 abnormal lacrimal gland morphology 0.130211150100721 0.355348585710963 0.940301419304492 0.714285714285714 17.3 17 3 abnormal axial mesoderm 0.130211150100721 0.355348585710963 0.940301419304492 0.714285714285714 17.3 17 3 absent amniotic folds 0.130211150100721 0.355348585710963 0.940301419304492 0.714285714285714 17.3 17 3 abnormal gastrulation movements 0.130211150100721 0.355348585710963 0.940301419304492 0.714285714285714 17.3 17 3 abnormal lymph node primary follicle morphology 0.130211150100721 0.355348585710963 0.940301419304492 0.714285714285714 17.3 17 3 abnormal melanocyte morphology 0.130211150100721 0.355348585710963 0.940301419304492 0.714285714285714 17.3 17 3 increased retinal ganglion cell number 0.130211150100721 0.355348585710963 0.940301419304492 0.714285714285714 17.3 17 3 decreased urine calcium level 0.130211150100721 0.355348585710963 0.940301419304492 0.714285714285714 17.3 17 3 detached tectorial membrane 0.130211150100721 0.355348585710963 0.940301419304492 0.714285714285714 17.3 17 3 abnormal sinus venosus morphology 0.130211150100721 0.355348585710963 0.940301419304492 0.714285714285714 17.3 17 3 anuria 0.130211150100721 0.355348585710963 0.940301419304492 0.714285714285714 17.3 17 3 increased ectoderm apoptosis 0.130211150100721 0.355348585710963 0.940301419304492 0.714285714285714 17.3 17 3 renal necrosis 0.130211150100721 0.355348585710963 0.940301419304492 0.714285714285714 17.3 17 3 abnormal cochlear nerve compound action potential 0.130211150100721 0.355348585710963 0.940301419304492 0.714285714285714 17.3 17 3 abnormal negative T cell selection 0.130211150100721 0.355348585710963 0.940301419304492 0.714285714285714 17.3 17 3 abnormal MHC II cell surface expression on macrophages 0.130211150100721 0.355348585710963 0.940301419304492 0.714285714285714 17.3 17 3 postaxial polydactyly 0.130211150100721 0.355348585710963 0.940301419304492 0.714285714285714 17.3 17 3 abnormal prostaglandin level 0.130211150100721 0.355348585710963 0.940301419304492 0.714285714285714 17.3 17 3 abnormal sperm annulus morphology 0.130211150100721 0.355348585710963 0.940301419304492 0.714285714285714 17.3 17 3 increased DN3 thymocyte number 0.130211150100721 0.355348585710963 0.940301419304492 0.714285714285714 17.3 17 3 decreased skeletal muscle glycogen level 0.130211150100721 0.355348585710963 0.940301419304492 0.714285714285714 17.3 17 3 heart right ventricle outflow tract stenosis 0.130211150100721 0.355348585710963 0.940301419304492 0.714285714285714 17.3 17 3 heart block 0.130211150100721 0.355348585710963 0.940301419304492 0.714285714285714 17.3 17 3 abnormal conotruncal ridge morphology 0.130211150100721 0.355348585710963 0.940301419304492 0.714285714285714 17.3 17 3 thick mitral valve cusps 0.130211150100721 0.355348585710963 0.940301419304492 0.714285714285714 17.3 17 3 abnormal tricarboxylic acid cycle 0.130211150100721 0.355348585710963 0.940301419304492 0.714285714285714 17.3 17 3 increased circulating lactate dehydrogenase level 0.130211150100721 0.355348585710963 0.940301419304492 0.714285714285714 17.3 17 3 small tail bud 0.130211150100721 0.355348585710963 0.940301419304492 0.714285714285714 17.3 17 3 impaired mammary gland growth during pregnancy 0.130211150100721 0.355348585710963 0.940301419304492 0.714285714285714 17.3 17 3 absent heart tube 0.130211150100721 0.355348585710963 0.940301419304492 0.714285714285714 17.3 17 3 decreased CD8-positive, naive alpha-beta T cell number 0.130211150100721 0.355348585710963 0.940301419304492 0.714285714285714 17.3 17 3 decreased volumetric bone mineral density 0.130211150100721 0.355348585710963 0.940301419304492 0.714285714285714 17.3 17 3 embryo tumor 0.130211150100721 0.355348585710963 0.940301419304492 0.714285714285714 17.3 17 3 decreased collagen level 0.130211150100721 0.355348585710963 0.940301419304492 0.714285714285714 17.3 17 3 domed cranium 1.57931287658576e-06 3.05723017938295e-05 0.940301419304492 0.714285714285714 17.3 17 3 abnormal reproductive system morphology 0.000196947798497436 0.00207587986763717 0.940301419304492 0.714285714285714 17.3 17 3 abnormal dermal layer morphology 0.000673465519841252 0.00597235465456368 0.940301419304492 0.714285714285714 17.3 17 3 ovary cysts 0.000673465519841252 0.00597235465456368 0.940301419304492 0.714285714285714 17.3 17 3 abnormal artery morphology 0.000673465519841252 0.00597235465456368 0.940301419304492 0.714285714285714 17.3 17 3 increased red blood cell distribution width 0.000673465519841252 0.00597235465456368 0.940301419304492 0.714285714285714 17.3 17 3 abnormal scapula morphology 0.00836714646270145 0.0466665399685423 0.940301419304492 0.714285714285714 17.3 17 3 abnormal eye pigmentation 0.00836714646270145 0.0466665399685423 0.940301419304492 0.714285714285714 17.3 17 3 embryonic lethality at implantation, complete penetrance 0.00836714646270145 0.0466665399685423 0.940301419304492 0.714285714285714 17.3 17 3 distended pericardium 4.11879978036661e-05 0.000532234517073348 0.93668487538409 0.711538461538462 17.3 17 3 abnormal ectoderm development 0.00013863363372175 0.00154295822766377 0.936122301885361 0.711111111111111 17.3 17 3 small placenta 0.00013863363372175 0.00154295822766377 0.936122301885361 0.711111111111111 17.3 17 3 abnormal rib morphology 4.44852002554097e-11 1.87554128195477e-09 0.936122301885361 0.711111111111111 17.3 17 3 abnormal sternum morphology 2.63717898193296e-06 4.71941202702031e-05 0.934850396583886 0.710144927536232 17.3 17 3 perimembraneous ventricular septal defect 2.63717898193296e-06 4.71941202702031e-05 0.934850396583886 0.710144927536232 17.3 17 3 abnormal object recognition memory 0.00162697183499678 0.0123953826632603 0.934234958534786 0.709677419354839 17.3 17 3 decreased double-negative T cell number 0.00162697183499678 0.0123953826632603 0.934234958534786 0.709677419354839 17.3 17 3 small cranium 0.00162697183499678 0.0123953826632603 0.934234958534786 0.709677419354839 17.3 17 3 decreased susceptibility to bacterial infection induced morbidity/mortality 0.00162697183499678 0.0123953826632603 0.934234958534786 0.709677419354839 17.3 17 3 abnormal head morphology 2.90957466041863e-05 0.000396579011933772 0.933462863527732 0.709090909090909 17.3 17 3 abnormal nervous system morphology 5.68358193965389e-07 1.23475197160603e-05 0.933159889537623 0.708860759493671 17.3 17 3 abnormal forebrain development 1.87152143377581e-06 3.51351665397534e-05 0.932465574143621 0.708333333333333 17.3 17 3 increased susceptibility to bacterial infection induced morbidity/mortality 1.87152143377581e-06 3.51351665397534e-05 0.932465574143621 0.708333333333333 17.3 17 3 curly tail 9.75700290355022e-05 0.00112104132667811 0.932465574143621 0.708333333333333 17.3 17 3 decreased metastatic potential 0.00573741811315318 0.0355462703772566 0.932465574143621 0.708333333333333 17.3 17 3 abnormal nursing 0.00573741811315318 0.0355462703772566 0.932465574143621 0.708333333333333 17.3 17 3 hemolytic anemia 0.00573741811315318 0.0355462703772566 0.932465574143621 0.708333333333333 17.3 17 3 abnormal vasodilation 0.00573741811315318 0.0355462703772566 0.932465574143621 0.708333333333333 17.3 17 3 blindness 0.00573741811315318 0.0355462703772566 0.932465574143621 0.708333333333333 17.3 17 3 abnormal tumor morphology 0.00573741811315318 0.0355462703772566 0.932465574143621 0.708333333333333 17.3 17 3 abnormal osteoblast morphology 0.00573741811315318 0.0355462703772566 0.932465574143621 0.708333333333333 17.3 17 3 anophthalmia 1.2321051018355e-07 2.94698215463058e-06 0.931849271715238 0.707865168539326 17.3 17 3 Leydig cell hyperplasia 0.000330167717957744 0.00321445087444183 0.931127746921034 0.707317073170732 17.3 17 3 thick ventricular wall 0.000330167717957744 0.00321445087444183 0.931127746921034 0.707317073170732 17.3 17 3 palatal shelves fail to meet at midline 0.000330167717957744 0.00321445087444183 0.931127746921034 0.707317073170732 17.3 17 3 delayed bone ossification 1.32763904702473e-06 2.61067362013757e-05 0.930271537498577 0.706666666666667 17.3 17 3 abnormal neurocranium morphology 1.32763904702473e-06 2.61067362013757e-05 0.930271537498577 0.706666666666667 17.3 17 3 premature death 4.74879342816129e-61 4.72504946102048e-58 0.92959880152379 0.706155632984901 17.3 17 3 increased susceptibility to viral infection induced morbidity/mortality 0.00113120145856652 0.00939070177092663 0.929239049665616 0.705882352941177 17.3 17 3 abnormal adipose tissue morphology 0.0209698986793294 0.0961523003960035 0.929239049665616 0.705882352941177 17.3 17 3 abnormal glutamate-mediated receptor currents 0.0209698986793294 0.0961523003960035 0.929239049665616 0.705882352941177 17.3 17 3 abnormal melanosome morphology 0.0209698986793294 0.0961523003960035 0.929239049665616 0.705882352941177 17.3 17 3 increased brain size 0.0209698986793294 0.0961523003960035 0.929239049665616 0.705882352941177 17.3 17 3 abnormal ductus venosus valve morphology 0.0209698986793294 0.0961523003960035 0.929239049665616 0.705882352941177 17.3 17 3 decreased hematocrit 1.91829846721269e-11 8.59777916611091e-10 0.92870866208019 0.705479452054795 17.3 17 3 increased urine protein level 9.41508066291686e-07 1.94356955593408e-05 0.928246272903152 0.705128205128205 17.3 17 3 abnormal behavior 2.14693451092464e-20 3.68310316960347e-18 0.92812485416242 0.705035971223022 17.3 17 3 increased circulating HDL cholesterol level 1.35907639041588e-08 3.90832661405722e-07 0.927764067047099 0.704761904761905 17.3 17 3 abnormal bone structure 1.41413646035535e-14 9.63743683598337e-13 0.927634146298318 0.704663212435233 17.3 17 3 muscular atrophy 0.000231287498323081 0.00237248516321098 0.927479127223067 0.704545454545455 17.3 17 3 prenatal lethality, incomplete penetrance 5.35007928401248e-22 1.06466577751848e-19 0.926691793498769 0.703947368421053 17.3 17 3 increased cell proliferation 4.83272961666705e-05 0.000610224107688289 0.926371027907388 0.703703703703704 17.3 17 3 abnormal small intestine morphology 4.83272961666705e-05 0.000610224107688289 0.926371027907388 0.703703703703704 17.3 17 3 abnormal osteoblast physiology 4.83272961666705e-05 0.000610224107688289 0.926371027907388 0.703703703703704 17.3 17 3 abnormal trigeminal ganglion morphology 0.00394576325372034 0.0259428392149466 0.926371027907388 0.703703703703704 17.3 17 3 abnormal blood vessel morphology 3.15677391439752e-11 1.35387501932135e-09 0.926034777080562 0.703448275862069 17.3 17 3 increased sacral vertebrae number 1.02437822722248e-05 0.000154893738996216 0.925609209627859 0.703125 17.3 17 3 abnormal branching of the mammary ductal tree 0.00078735358763587 0.00676525751034275 0.925053288180635 0.702702702702703 17.3 17 3 increased erythroid progenitor cell number 0.00078735358763587 0.00676525751034275 0.925053288180635 0.702702702702703 17.3 17 3 decreased compact bone thickness 7.2319421360359e-06 0.000115687820343339 0.923460199854262 0.701492537313433 17.3 17 3 kyphosis 2.6245284479666e-11 1.14535342356437e-09 0.921495390918402 0.7 17.3 17 3 abnormal liver physiology 5.16633747770569e-08 1.31541199801789e-06 0.921495390918402 0.7 17.3 17 3 abnormal posture 1.09785082500641e-06 2.21125824065056e-05 0.921495390918402 0.7 17.3 17 3 abnormal circulating protein level 0.000113637521187657 0.00128780562165967 0.921495390918402 0.7 17.3 17 3 gastrointestinal hemorrhage 0.00272059270249988 0.0193707878742637 0.921495390918402 0.7 17.3 17 3 abnormal fat pad morphology 0.00272059270249988 0.0193707878742637 0.921495390918402 0.7 17.3 17 3 abnormal lens epithelium morphology 0.0141546975364944 0.0721512502500612 0.921495390918402 0.7 17.3 17 3 abnormal optic stalk morphology 0.0141546975364944 0.0721512502500612 0.921495390918402 0.7 17.3 17 3 decreased circulating VLDL cholesterol level 0.0141546975364944 0.0721512502500612 0.921495390918402 0.7 17.3 17 3 abnormal auchene hair morphology 0.082229570372935 0.249750984496552 0.921495390918402 0.7 17.3 17 3 retarded hair growth 0.082229570372935 0.249750984496552 0.921495390918402 0.7 17.3 17 3 kidney hemorrhage 0.082229570372935 0.249750984496552 0.921495390918402 0.7 17.3 17 3 enlarged testis 0.082229570372935 0.249750984496552 0.921495390918402 0.7 17.3 17 3 rhinitis 0.082229570372935 0.249750984496552 0.921495390918402 0.7 17.3 17 3 abnormal mammary gland physiology 0.082229570372935 0.249750984496552 0.921495390918402 0.7 17.3 17 3 ketoaciduria 0.082229570372935 0.249750984496552 0.921495390918402 0.7 17.3 17 3 intestinal edema 0.082229570372935 0.249750984496552 0.921495390918402 0.7 17.3 17 3 bifid ureter 0.082229570372935 0.249750984496552 0.921495390918402 0.7 17.3 17 3 abnormal glial cell physiology 0.082229570372935 0.249750984496552 0.921495390918402 0.7 17.3 17 3 abnormal submandibular gland morphology 0.082229570372935 0.249750984496552 0.921495390918402 0.7 17.3 17 3 abnormal respiratory conducting tube morphology 0.082229570372935 0.249750984496552 0.921495390918402 0.7 17.3 17 3 increased susceptibility to atherosclerosis 0.082229570372935 0.249750984496552 0.921495390918402 0.7 17.3 17 3 abnormal hippocampus neuron morphology 0.082229570372935 0.249750984496552 0.921495390918402 0.7 17.3 17 3 abnormal cerebellar granule cell migration 0.082229570372935 0.249750984496552 0.921495390918402 0.7 17.3 17 3 abnormal vibrissa follicle morphology 0.082229570372935 0.249750984496552 0.921495390918402 0.7 17.3 17 3 thick aortic valve 0.082229570372935 0.249750984496552 0.921495390918402 0.7 17.3 17 3 decreased circulating lactate level 0.082229570372935 0.249750984496552 0.921495390918402 0.7 17.3 17 3 abnormal renal glomerulus morphology 1.84295303869273e-08 5.12217394832196e-07 0.917872211137596 0.697247706422018 17.3 17 3 decreased body length 4.83054602935281e-19 6.00799162400756e-17 0.91765182307307 0.697080291970803 17.3 17 3 abnormal neuron morphology 8.44570560747081e-08 2.09041718393867e-06 0.917506233381959 0.696969696969697 17.3 17 3 abnormal tooth development 0.00188008127528426 0.0140021023121844 0.917506233381959 0.696969696969697 17.3 17 3 abnormal ovarian folliculogenesis 0.00188008127528426 0.0140021023121844 0.917506233381959 0.696969696969697 17.3 17 3 abnormal QRS complex 0.00188008127528426 0.0140021023121844 0.917506233381959 0.696969696969697 17.3 17 3 cardiovascular system phenotype 0.00188008127528426 0.0140021023121844 0.917506233381959 0.696969696969697 17.3 17 3 abnormal visceral yolk sac morphology 1.79664319037276e-06 3.41156483668111e-05 0.916496320081594 0.69620253164557 17.3 17 3 abnormal myocardium layer morphology 1.79664319037276e-06 3.41156483668111e-05 0.916496320081594 0.69620253164557 17.3 17 3 abnormal nasal cavity morphology 0.00961288947182122 0.0528443371517244 0.915771817061766 0.695652173913043 17.3 17 3 abnormal cardiovascular development 0.00961288947182122 0.0528443371517244 0.915771817061766 0.695652173913043 17.3 17 3 abnormal chondrocyte physiology 0.00961288947182122 0.0528443371517244 0.915771817061766 0.695652173913043 17.3 17 3 sparse hair 1.26856941027206e-06 2.52445312644141e-05 0.915073820249981 0.695121951219512 17.3 17 3 cataract 4.65543155728806e-09 1.4658716454119e-07 0.913879726530647 0.694214876033058 17.3 17 3 abnormal lipid homeostasis 1.65751954285695e-09 5.4974398171422e-08 0.911369067941277 0.692307692307692 17.3 17 3 abnormal skin condition 0.000130493630577427 0.00147212202295397 0.911369067941277 0.692307692307692 17.3 17 3 abnormal nasal bone morphology 0.00656021661512701 0.0388508815551426 0.911369067941277 0.692307692307692 17.3 17 3 increased susceptibility to otitis media 0.00656021661512701 0.0388508815551426 0.911369067941277 0.692307692307692 17.3 17 3 absent teeth 0.0533779012957739 0.193553249960988 0.911369067941277 0.692307692307692 17.3 17 3 absent common myeloid progenitor cells 0.0533779012957739 0.193553249960988 0.911369067941277 0.692307692307692 17.3 17 3 absent myocardial trabeculae 0.0533779012957739 0.193553249960988 0.911369067941277 0.692307692307692 17.3 17 3 abnormal grip strength 0.0533779012957739 0.193553249960988 0.911369067941277 0.692307692307692 17.3 17 3 abnormal pulmonary alveolus epithelial cell morphology 0.0533779012957739 0.193553249960988 0.911369067941277 0.692307692307692 17.3 17 3 small interparietal bone 0.0533779012957739 0.193553249960988 0.911369067941277 0.692307692307692 17.3 17 3 increased cochlear inner hair cell number 0.0533779012957739 0.193553249960988 0.911369067941277 0.692307692307692 17.3 17 3 abnormal vertebral arch development 0.0533779012957739 0.193553249960988 0.911369067941277 0.692307692307692 17.3 17 3 small pituitary gland 0.0533779012957739 0.193553249960988 0.911369067941277 0.692307692307692 17.3 17 3 orthokeratosis 0.0533779012957739 0.193553249960988 0.911369067941277 0.692307692307692 17.3 17 3 empty decidua capsularis 0.0533779012957739 0.193553249960988 0.911369067941277 0.692307692307692 17.3 17 3 azoospermia 2.87245669694663e-11 1.24264974498343e-09 0.910732192282338 0.691823899371069 17.3 17 3 ventricular septal defect 8.32420583075778e-10 2.83650164438493e-08 0.909879902797582 0.691176470588235 17.3 17 3 abnormal platelet physiology 9.13154657769308e-05 0.00106143561271082 0.909527918309072 0.690909090909091 17.3 17 3 decreased inflammatory response 1.45360677839012e-06 2.82488036034799e-05 0.908958038661009 0.69047619047619 17.3 17 3 abnormal cartilage morphology 0.000627350615215354 0.00568500785190598 0.908958038661009 0.69047619047619 17.3 17 3 dermatitis 6.39438921997037e-05 0.00078263616883672 0.907877232431923 0.689655172413793 17.3 17 3 decreased granulocyte number 0.00449474859844554 0.0291163727568575 0.907877232431923 0.689655172413793 17.3 17 3 focal hair loss 0.00449474859844554 0.0291163727568575 0.907877232431923 0.689655172413793 17.3 17 3 abnormal outer ear morphology 0.00449474859844554 0.0291163727568575 0.907877232431923 0.689655172413793 17.3 17 3 postnatal growth retardation 1.33039042879177e-38 7.35410264804342e-36 0.907728886478912 0.689542483660131 17.3 17 3 decreased grip strength 1.00951282230903e-14 7.27873375505425e-13 0.907669954524975 0.689497716894977 17.3 17 3 thin ventricular wall 7.22880384882223e-07 1.53035315522939e-05 0.906868479951443 0.688888888888889 17.3 17 3 trabecula carnea hypoplasia 0.000436449627083172 0.00416763319527597 0.906868479951443 0.688888888888889 17.3 17 3 decreased bone mineral density 2.26450114163211e-17 2.34706107908745e-15 0.905658735435379 0.68796992481203 17.3 17 3 neonatal lethality 0.00308977081578139 0.020942247695521 0.905040116080574 0.6875 17.3 17 3 pancreatic islet hyperplasia 0.00308977081578139 0.020942247695521 0.905040116080574 0.6875 17.3 17 3 abnormal tympanic ring morphology 0.0352432144143848 0.137950426208941 0.905040116080574 0.6875 17.3 17 3 abnormal mouth morphology 0.0352432144143848 0.137950426208941 0.905040116080574 0.6875 17.3 17 3 mixed cellular infiltration to dermis 0.0352432144143848 0.137950426208941 0.905040116080574 0.6875 17.3 17 3 intraventricular hemorrhage 0.0352432144143848 0.137950426208941 0.905040116080574 0.6875 17.3 17 3 abnormal meiosis 0.0352432144143848 0.137950426208941 0.905040116080574 0.6875 17.3 17 3 white spotting 0.0352432144143848 0.137950426208941 0.905040116080574 0.6875 17.3 17 3 abnormal pulmonary elastic fiber morphology 0.0352432144143848 0.137950426208941 0.905040116080574 0.6875 17.3 17 3 abnormal molar crown morphology 0.0352432144143848 0.137950426208941 0.905040116080574 0.6875 17.3 17 3 bowed radius 0.0352432144143848 0.137950426208941 0.905040116080574 0.6875 17.3 17 3 increased thymus weight 0.0352432144143848 0.137950426208941 0.905040116080574 0.6875 17.3 17 3 abnormal Langerhans cell physiology 0.0352432144143848 0.137950426208941 0.905040116080574 0.6875 17.3 17 3 loose skin 0.0352432144143848 0.137950426208941 0.905040116080574 0.6875 17.3 17 3 embryonic lethality between somite formation and embryo turning, incomplete penetrance 0.0352432144143848 0.137950426208941 0.905040116080574 0.6875 17.3 17 3 abnormal lymph node morphology 0.000304019596022458 0.00298322976373121 0.905040116080574 0.6875 17.3 17 3 hydroencephaly 2.77331489393062e-08 7.45796843097557e-07 0.904324669348494 0.68695652173913 17.3 17 3 abnormal lipid level 2.34709597943464e-06 4.23072554264035e-05 0.904048834463837 0.686746987951807 17.3 17 3 small lung 0.000212011293069338 0.00220199620672225 0.903426853841571 0.686274509803922 17.3 17 3 abnormal hippocampus pyramidal cell morphology 0.00212989805214894 0.015744788721309 0.902689362532312 0.685714285714286 17.3 17 3 diluted coat color 0.000147999346050263 0.00162064516733468 0.901992842962457 0.685185185185185 17.3 17 3 abnormal maxilla morphology 0.000147999346050263 0.00162064516733468 0.901992842962457 0.685185185185185 17.3 17 3 abnormal seminiferous tubule morphology 5.41157015948513e-10 1.92304011024561e-08 0.901658895223486 0.684931506849315 17.3 17 3 abnormal frontal bone morphology 0.00147173249139799 0.0114431464000546 0.900709780596934 0.684210526315789 17.3 17 3 increased grooming behavior 0.00147173249139799 0.0114431464000546 0.900709780596934 0.684210526315789 17.3 17 3 abnormal compact bone morphology 0.00147173249139799 0.0114431464000546 0.900709780596934 0.684210526315789 17.3 17 3 decreased total retina thickness 0.00147173249139799 0.0114431464000546 0.900709780596934 0.684210526315789 17.3 17 3 altered susceptibility to infection 0.0235419851338232 0.106280740508866 0.900709780596934 0.684210526315789 17.3 17 3 abnormal long term depression 0.0235419851338232 0.106280740508866 0.900709780596934 0.684210526315789 17.3 17 3 decreased germ cell number 0.0235419851338232 0.106280740508866 0.900709780596934 0.684210526315789 17.3 17 3 abnormal metatarsal bone morphology 0.0235419851338232 0.106280740508866 0.900709780596934 0.684210526315789 17.3 17 3 oliguria 0.0235419851338232 0.106280740508866 0.900709780596934 0.684210526315789 17.3 17 3 thin interventricular septum 0.0235419851338232 0.106280740508866 0.900709780596934 0.684210526315789 17.3 17 3 epidermal hyperplasia 7.23159316808354e-05 0.000871118063225559 0.899555024467964 0.683333333333333 17.3 17 3 abnormal brain morphology 9.60234513419797e-11 3.85255379376088e-09 0.899418748899949 0.683229813664596 17.3 17 3 liver fibrosis 0.00101905381686857 0.00853500461097835 0.899019893578929 0.682926829268293 17.3 17 3 decreased bone mineral content 2.1235307448299e-13 1.22843784366613e-11 0.89871116421987 0.682692307692308 17.3 17 3 skin lesions 5.06104628025827e-05 0.000632630785032283 0.898510245113181 0.682539682539683 17.3 17 3 infertility 1.42866872232709e-07 3.36854355145841e-06 0.898119673391767 0.682242990654206 17.3 17 3 teratozoospermia 1.86586452215757e-06 3.51351665397534e-05 0.897560445699742 0.681818181818182 17.3 17 3 decreased macrophage cell number 0.00070688742459006 0.00612551229961147 0.897560445699742 0.681818181818182 17.3 17 3 decreased sensitivity to induced morbidity/mortality 0.00070688742459006 0.00612551229961147 0.897560445699742 0.681818181818182 17.3 17 3 abnormal long bone epiphysis morphology 0.0158600815800066 0.0774326848484128 0.897560445699742 0.681818181818182 17.3 17 3 abnormal tail movements 0.0158600815800066 0.0774326848484128 0.897560445699742 0.681818181818182 17.3 17 3 abnormal chorion morphology 0.0158600815800066 0.0774326848484128 0.897560445699742 0.681818181818182 17.3 17 3 abnormal sperm midpiece morphology 0.0158600815800066 0.0774326848484128 0.897560445699742 0.681818181818182 17.3 17 3 pulmonary vascular congestion 0.0158600815800066 0.0774326848484128 0.897560445699742 0.681818181818182 17.3 17 3 decreased spleen weight 2.48400091439111e-05 0.000344231324487347 0.896693237539646 0.681159420289855 17.3 17 3 perinatal lethality, complete penetrance 1.69539122979692e-13 1.00411563907615e-11 0.896155812764375 0.68075117370892 17.3 17 3 short stride length 0.000341706315159326 0.0033009493551799 0.895166951177876 0.68 17.3 17 3 mandible hypoplasia 0.0107546101933262 0.0577798981768873 0.895166951177876 0.68 17.3 17 3 decreased acute inflammation 0.0107546101933262 0.0577798981768873 0.895166951177876 0.68 17.3 17 3 abnormal spermatogenesis 9.60354307955937e-12 4.4651987682998e-10 0.894308415099381 0.679347826086957 17.3 17 3 decreased heart weight 6.02506728533358e-06 9.86010188964953e-05 0.893866781314147 0.679012345679012 17.3 17 3 abnormal circulating cholesterol level 0.00733027598204102 0.041821241984695 0.893286348339267 0.678571428571429 17.3 17 3 straub tail 0.00733027598204102 0.041821241984695 0.893286348339267 0.678571428571429 17.3 17 3 hypoxia 0.00733027598204102 0.041821241984695 0.893286348339267 0.678571428571429 17.3 17 3 increased susceptibility to parasitic infection 2.09244789779233e-06 3.86189243847906e-05 0.892241568984485 0.677777777777778 17.3 17 3 small testis 1.19639383542571e-16 1.10223320948943e-14 0.891923592659116 0.677536231884058 17.3 17 3 prenatal lethality 8.09917290522105e-05 0.000954819554584709 0.891769733146841 0.67741935483871 17.3 17 3 abnormal mitochondrial ATP synthesis coupled electron transport 0.00501719652425642 0.0321242634596855 0.891769733146841 0.67741935483871 17.3 17 3 impaired balance 5.13325393550149e-07 1.12501930965286e-05 0.890520755929548 0.676470588235294 17.3 17 3 abnormal oocyte morphology 0.0034459208920577 0.0229190594090736 0.890520755929548 0.676470588235294 17.3 17 3 abnormal endoderm development 0.0034459208920577 0.0229190594090736 0.890520755929548 0.676470588235294 17.3 17 3 increased heart weight 4.91161755159482e-09 1.53681115214995e-07 0.890242207053749 0.676258992805755 17.3 17 3 increased brown adipose tissue amount 0.00237364277448858 0.0171640593068033 0.889474315558303 0.675675675675676 17.3 17 3 malocclusion 0.00237364277448858 0.0171640593068033 0.889474315558303 0.675675675675676 17.3 17 3 abnormal vocalization 0.00237364277448858 0.0171640593068033 0.889474315558303 0.675675675675676 17.3 17 3 abnormal calcium ion homeostasis 0.00237364277448858 0.0171640593068033 0.889474315558303 0.675675675675676 17.3 17 3 abnormal respiratory electron transport chain 0.00237364277448858 0.0171640593068033 0.889474315558303 0.675675675675676 17.3 17 3 abnormal muscle physiology 3.31761428032743e-06 5.791274050747e-05 0.887475496871655 0.674157303370786 17.3 17 3 decreased birth weight 1.63995090775223e-06 3.16230843646021e-05 0.886852707049289 0.673684210526316 17.3 17 3 impaired glucose tolerance 1.18151971004685e-14 8.27895853166634e-13 0.886461579973348 0.673387096774194 17.3 17 3 decreased circulating calcium level 0.000264516211056553 0.00266390313766468 0.885592973090413 0.672727272727273 17.3 17 3 abnormal rostral-caudal axis patterning 0.000264516211056553 0.00266390313766468 0.885592973090413 0.672727272727273 17.3 17 3 increased bone mineral density 1.9964241104021e-07 4.6196325345351e-06 0.885381159415911 0.672566371681416 17.3 17 3 decreased circulating LDL cholesterol level 8.99174204568141e-05 0.00104763270906944 0.884471022533288 0.671875 17.3 17 3 increased insulin sensitivity 6.07910467116907e-09 1.86688553944853e-07 0.883751823458208 0.671328671328671 17.3 17 3 abnormal fertility/fecundity 3.08062637484692e-05 0.000417605346454045 0.883625717319016 0.671232876712329 17.3 17 3 decreased percent body fat/body weight 3.08062637484692e-05 0.000417605346454045 0.883625717319016 0.671232876712329 17.3 17 3 abnormal developmental patterning 1.06178676042241e-05 0.000158630304297342 0.882965966907877 0.670731707317073 17.3 17 3 abnormal glucose homeostasis 6.6215979728663e-11 2.74520415958415e-09 0.882436716578062 0.67032967032967 17.3 17 3 abnormal coat/hair pigmentation 3.13811695531744e-07 7.12882733000195e-06 0.881532580597961 0.669642857142857 17.3 17 3 embryonic lethality during organogenesis, incomplete penetrance 2.57790148472095e-13 1.4741448145387e-11 0.88143037392195 0.669565217391304 17.3 17 3 neonatal lethality, incomplete penetrance 8.06270914809313e-15 5.89882029584755e-13 0.880990099009901 0.669230769230769 17.3 17 3 abnormal enzyme/coenzyme activity 1.67077103213636e-09 5.50469263899232e-08 0.880409609157709 0.668789808917197 17.3 17 3 ataxia 9.12663881726568e-12 4.28349321848083e-10 0.87978697152747 0.668316831683168 17.3 17 3 perinatal lethality, incomplete penetrance 5.69692777579389e-13 3.08067561788854e-11 0.879556283367122 0.668141592920354 17.3 17 3 decreased total body fat amount 2.17330595924682e-18 2.35047764070716e-16 0.878928452415756 0.667664670658683 17.3 17 3 decreased body weight 7.1248091900163e-65 1.18153085734437e-61 0.878323555156474 0.667205169628433 17.3 17 3 abnormal response to novel object 0.000601096359339302 0.00549180020277537 0.877614658017526 0.666666666666667 17.3 17 3 abnormal thrombosis 0.000601096359339302 0.00549180020277537 0.877614658017526 0.666666666666667 17.3 17 3 altered response to myocardial infarction 0.00124776301960384 0.0100609741045852 0.877614658017526 0.666666666666667 17.3 17 3 decreased exploration in new environment 1.17007951039027e-05 0.000173765539229599 0.877614658017526 0.666666666666667 17.3 17 3 increased neuron apoptosis 1.66778080976296e-05 0.000241690505411532 0.877614658017526 0.666666666666667 17.3 17 3 increased circulating alanine transaminase level 2.37850285556699e-05 0.000331458030992879 0.877614658017526 0.666666666666667 17.3 17 3 abnormal eating behavior 0.00020307947072586 0.00211807204792695 0.877614658017526 0.666666666666667 17.3 17 3 oligodactyly 0.000865345415192074 0.00737173534345988 0.877614658017526 0.666666666666667 17.3 17 3 disheveled coat 0.00180246022017501 0.0135661718538134 0.877614658017526 0.666666666666667 17.3 17 3 skin edema 0.00180246022017501 0.0135661718538134 0.877614658017526 0.666666666666667 17.3 17 3 belly spot 0.00550914989677564 0.034693697134758 0.877614658017526 0.666666666666667 17.3 17 3 abnormal heart tube morphology 0.00804306039033683 0.0450103773250008 0.877614658017526 0.666666666666667 17.3 17 3 rectal prolapse 0.0117891233379403 0.0628626887526828 0.877614658017526 0.666666666666667 17.3 17 3 thin epidermis 0.0117891233379403 0.0628626887526828 0.877614658017526 0.666666666666667 17.3 17 3 abnormal fetal cardiomyocyte proliferation 0.0117891233379403 0.0628626887526828 0.877614658017526 0.666666666666667 17.3 17 3 thick interventricular septum 0.0117891233379403 0.0628626887526828 0.877614658017526 0.666666666666667 17.3 17 3 abnormal bone trabecula morphology 0.0117891233379403 0.0628626887526828 0.877614658017526 0.666666666666667 17.3 17 3 abnormal startle reflex 0.0173638321891573 0.0841139874791212 0.877614658017526 0.666666666666667 17.3 17 3 abnormal cardiac muscle contractility 0.0173638321891573 0.0841139874791212 0.877614658017526 0.666666666666667 17.3 17 3 abnormal truncus arteriosus septation 0.0173638321891573 0.0841139874791212 0.877614658017526 0.666666666666667 17.3 17 3 small ears 0.0257297996840804 0.114700495903495 0.877614658017526 0.666666666666667 17.3 17 3 trunk curl 0.0257297996840804 0.114700495903495 0.877614658017526 0.666666666666667 17.3 17 3 decreased cochlear outer hair cell number 0.0257297996840804 0.114700495903495 0.877614658017526 0.666666666666667 17.3 17 3 abnormal tumor vascularization 0.0257297996840804 0.114700495903495 0.877614658017526 0.666666666666667 17.3 17 3 abnormal mitral valve morphology 0.0384239491798928 0.149226500523003 0.877614658017526 0.666666666666667 17.3 17 3 abnormal radius morphology 0.0384239491798928 0.149226500523003 0.877614658017526 0.666666666666667 17.3 17 3 abnormal mammary gland morphology 0.0384239491798928 0.149226500523003 0.877614658017526 0.666666666666667 17.3 17 3 abnormal thyroid cartilage morphology 0.0384239491798928 0.149226500523003 0.877614658017526 0.666666666666667 17.3 17 3 absent allantois 0.0384239491798928 0.149226500523003 0.877614658017526 0.666666666666667 17.3 17 3 abnormal redox activity 0.0384239491798928 0.149226500523003 0.877614658017526 0.666666666666667 17.3 17 3 increased circulating glycerol level 0.0384239491798928 0.149226500523003 0.877614658017526 0.666666666666667 17.3 17 3 darkened coat color 0.0384239491798928 0.149226500523003 0.877614658017526 0.666666666666667 17.3 17 3 decreased pulmonary respiratory rate 0.0384239491798928 0.149226500523003 0.877614658017526 0.666666666666667 17.3 17 3 decreased hepatocyte number 0.057978845988466 0.202701868441756 0.877614658017526 0.666666666666667 17.3 17 3 vagina atresia 0.057978845988466 0.202701868441756 0.877614658017526 0.666666666666667 17.3 17 3 abnormal cricoid cartilage morphology 0.057978845988466 0.202701868441756 0.877614658017526 0.666666666666667 17.3 17 3 abnormal ear development 0.057978845988466 0.202701868441756 0.877614658017526 0.666666666666667 17.3 17 3 abnormal cerebral aqueduct morphology 0.057978845988466 0.202701868441756 0.877614658017526 0.666666666666667 17.3 17 3 absent chorion 0.057978845988466 0.202701868441756 0.877614658017526 0.666666666666667 17.3 17 3 abnormal coronary vessel morphology 0.057978845988466 0.202701868441756 0.877614658017526 0.666666666666667 17.3 17 3 decreased trabecular bone mass 0.057978845988466 0.202701868441756 0.877614658017526 0.666666666666667 17.3 17 3 mesocardia 0.0887689906304939 0.2669663436545 0.877614658017526 0.666666666666667 17.3 17 3 abnormal mating frequency 0.0887689906304939 0.2669663436545 0.877614658017526 0.666666666666667 17.3 17 3 abnormal tracheal ciliated epithelium morphology 0.0887689906304939 0.2669663436545 0.877614658017526 0.666666666666667 17.3 17 3 abnormal gastrocnemius morphology 0.0887689906304939 0.2669663436545 0.877614658017526 0.666666666666667 17.3 17 3 decreased left ventricle systolic pressure 0.0887689906304939 0.2669663436545 0.877614658017526 0.666666666666667 17.3 17 3 vestibular saccular macula degeneration 0.0887689906304939 0.2669663436545 0.877614658017526 0.666666666666667 17.3 17 3 abnormal cochlear outer hair cell physiology 0.0887689906304939 0.2669663436545 0.877614658017526 0.666666666666667 17.3 17 3 decreased renal glomerular filtration rate 0.0887689906304939 0.2669663436545 0.877614658017526 0.666666666666667 17.3 17 3 abnormal thymus corticomedullary boundary morphology 0.0887689906304939 0.2669663436545 0.877614658017526 0.666666666666667 17.3 17 3 increased skeletal muscle glycogen level 0.0887689906304939 0.2669663436545 0.877614658017526 0.666666666666667 17.3 17 3 distorted hair follicle pattern 0.138942111401638 0.372433730723681 0.877614658017526 0.666666666666667 17.3 17 3 abnormal urinary bladder urothelium morphology 0.138942111401638 0.372433730723681 0.877614658017526 0.666666666666667 17.3 17 3 abnormal sympathetic neuron morphology 0.138942111401638 0.372433730723681 0.877614658017526 0.666666666666667 17.3 17 3 multifocal hepatic necrosis 0.138942111401638 0.372433730723681 0.877614658017526 0.666666666666667 17.3 17 3 abnormal germ cell morphology 0.138942111401638 0.372433730723681 0.877614658017526 0.666666666666667 17.3 17 3 enlarged otoliths 0.138942111401638 0.372433730723681 0.877614658017526 0.666666666666667 17.3 17 3 abnormal lens capsule morphology 0.138942111401638 0.372433730723681 0.877614658017526 0.666666666666667 17.3 17 3 premature neuronal precursor differentiation 0.138942111401638 0.372433730723681 0.877614658017526 0.666666666666667 17.3 17 3 decreased susceptibility to induced choroidal neovascularization 0.138942111401638 0.372433730723681 0.877614658017526 0.666666666666667 17.3 17 3 decreased fear-related response 0.138942111401638 0.372433730723681 0.877614658017526 0.666666666666667 17.3 17 3 impaired febrile response 0.138942111401638 0.372433730723681 0.877614658017526 0.666666666666667 17.3 17 3 abnormal proprioceptive neuron morphology 0.138942111401638 0.372433730723681 0.877614658017526 0.666666666666667 17.3 17 3 decreased vestibular hair cell number 0.138942111401638 0.372433730723681 0.877614658017526 0.666666666666667 17.3 17 3 decreased cochlear hair cell number 0.138942111401638 0.372433730723681 0.877614658017526 0.666666666666667 17.3 17 3 positive geotaxis 0.138942111401638 0.372433730723681 0.877614658017526 0.666666666666667 17.3 17 3 axonal spheroids 0.138942111401638 0.372433730723681 0.877614658017526 0.666666666666667 17.3 17 3 prolonged RR interval 0.138942111401638 0.372433730723681 0.877614658017526 0.666666666666667 17.3 17 3 iris coloboma 0.138942111401638 0.372433730723681 0.877614658017526 0.666666666666667 17.3 17 3 decreased effector memory CD4-positive, alpha-beta T cell number 0.138942111401638 0.372433730723681 0.877614658017526 0.666666666666667 17.3 17 3 abnormal pulmonary alveolar system morphology 0.138942111401638 0.372433730723681 0.877614658017526 0.666666666666667 17.3 17 3 abnormal lung lobe morphology 0.138942111401638 0.372433730723681 0.877614658017526 0.666666666666667 17.3 17 3 trigeminal neuroma 0.138942111401638 0.372433730723681 0.877614658017526 0.666666666666667 17.3 17 3 cerebellum atrophy 0.138942111401638 0.372433730723681 0.877614658017526 0.666666666666667 17.3 17 3 decreased bone mineral density of femur 0.138942111401638 0.372433730723681 0.877614658017526 0.666666666666667 17.3 17 3 increased endoplasmic reticulum stress 0.138942111401638 0.372433730723681 0.877614658017526 0.666666666666667 17.3 17 3 abnormal lens morphology 9.36837592754448e-08 2.29594434677506e-06 0.874186475759645 0.6640625 17.3 17 3 double outlet right ventricle 1.08765026467468e-06 2.19961791331567e-05 0.873513654942678 0.663551401869159 17.3 17 3 small seminiferous tubules 5.30426337859008e-05 0.000661371185676332 0.871684829247137 0.662162162162162 17.3 17 3 increased blood urea nitrogen level 1.79154095873657e-08 5.00725633130024e-07 0.871562143134646 0.662068965517241 17.3 17 3 abnormal ovary morphology 7.57678266367963e-05 0.000906117638264572 0.871434273101909 0.661971830985915 17.3 17 3 increased circulating free fatty acid level 7.57678266367963e-05 0.000906117638264572 0.871434273101909 0.661971830985915 17.3 17 3 abnormal eye morphology 3.59774748516951e-08 9.52063496740335e-07 0.871300883499414 0.661870503597122 17.3 17 3 decreased circulating alanine transaminase level 0.000108309480850519 0.00123871187869272 0.871161609061515 0.661764705882353 17.3 17 3 decreased monocyte cell number 0.000154952990709099 0.00167536999104402 0.870863776032776 0.661538461538462 17.3 17 3 decreased circulating cholesterol level 3.01726184610869e-10 1.11111491991845e-08 0.87042109524689 0.66120218579235 17.3 17 3 increased hemoglobin content 0.000318026524378155 0.00311453141492386 0.870177245661445 0.661016949152542 17.3 17 3 abnormal testis morphology 5.89313608253806e-07 1.27471095698378e-05 0.869983226208678 0.660869565217391 17.3 17 3 increased circulating bilirubin level 0.000655557932071909 0.00589765047388381 0.869335274451323 0.660377358490566 17.3 17 3 atrioventricular septal defect 0.000655557932071909 0.00589765047388381 0.869335274451323 0.660377358490566 17.3 17 3 reduced female fertility 1.98222221780155e-12 9.96116720561888e-11 0.868157603513027 0.65948275862069 17.3 17 3 small spleen 9.81520337042985e-06 0.000149787229349351 0.867970540896454 0.659340659340659 17.3 17 3 abnormal liver morphology 6.58988669621291e-10 2.2926354065496e-08 0.867808907648615 0.659217877094972 17.3 17 3 abnormal cholesterol homeostasis 0.00283490818567634 0.019615672077524 0.866912040236824 0.658536585365854 17.3 17 3 hunched posture 4.04440327583223e-05 0.000523981934824619 0.866505611713507 0.658227848101266 17.3 17 3 thick pulmonary interalveolar septum 0.00596829800188284 0.0365846201868639 0.865077305760133 0.657142857142857 17.3 17 3 abnormal midbrain development 0.00596829800188284 0.0365846201868639 0.865077305760133 0.657142857142857 17.3 17 3 abnormal embryonic epiblast morphology 0.00596829800188284 0.0365846201868639 0.865077305760133 0.657142857142857 17.3 17 3 impaired adaptive thermogenesis 0.00596829800188284 0.0365846201868639 0.865077305760133 0.657142857142857 17.3 17 3 cleft palate 1.72166973925942e-07 4.04023912868662e-06 0.864215960948556 0.656488549618321 17.3 17 3 kidney cortex cysts 0.00869682742225412 0.0482887460108418 0.863901928986002 0.65625 17.3 17 3 failure of primitive streak formation 0.00869682742225412 0.0482887460108418 0.863901928986002 0.65625 17.3 17 3 decreased susceptibility to parasitic infection 0.00869682742225412 0.0482887460108418 0.863901928986002 0.65625 17.3 17 3 decreased insulin secretion 1.5156050055211e-05 0.000221118325585556 0.862987747050567 0.655555555555556 17.3 17 3 enlarged heart 5.08245145841328e-12 2.43126884669289e-10 0.862483370810327 0.655172413793103 17.3 17 3 abnormal microglial cell morphology 0.0127177780108724 0.0668119805745411 0.862483370810327 0.655172413793103 17.3 17 3 polychromatophilia 0.0127177780108724 0.0668119805745411 0.862483370810327 0.655172413793103 17.3 17 3 abnormal learning/memory/conditioning 0.000709205042125871 0.00612551229961147 0.861658027871753 0.654545454545455 17.3 17 3 abnormal joint morphology 0.000709205042125871 0.00612551229961147 0.861658027871753 0.654545454545455 17.3 17 3 abnormal snout morphology 0.00101902168593625 0.00853500461097835 0.86073745305565 0.653846153846154 17.3 17 3 ventricular hypoplasia 0.0186773536188135 0.0890036726567022 0.86073745305565 0.653846153846154 17.3 17 3 abnormal heart morphology 7.77299337735124e-12 3.68291829069737e-10 0.860518268575626 0.653679653679654 17.3 17 3 abnormal long bone hypertrophic chondrocyte zone 0.00146617025066342 0.0114431464000546 0.859704154792678 0.653061224489796 17.3 17 3 increased circulating LDL cholesterol level 0.00146617025066342 0.0114431464000546 0.859704154792678 0.653061224489796 17.3 17 3 decreased circulating creatinine level 0.00146617025066342 0.0114431464000546 0.859704154792678 0.653061224489796 17.3 17 3 decreased body size 3.70166032929866e-37 1.84157601382608e-34 0.859468490276562 0.652882205513785 17.3 17 3 delayed wound healing 0.00211274249768306 0.0156412111993649 0.858536078495406 0.652173913043478 17.3 17 3 abnormal cranial nerve morphology 0.0275735667828541 0.120121273857004 0.858536078495406 0.652173913043478 17.3 17 3 abnormal circulating insulin level 0.0275735667828541 0.120121273857004 0.858536078495406 0.652173913043478 17.3 17 3 abnormal sacral vertebrae morphology 0.0275735667828541 0.120121273857004 0.858536078495406 0.652173913043478 17.3 17 3 abnormal Wolffian duct morphology 0.0275735667828541 0.120121273857004 0.858536078495406 0.652173913043478 17.3 17 3 dilated heart 0.0275735667828541 0.120121273857004 0.858536078495406 0.652173913043478 17.3 17 3 abnormal corneal stroma morphology 0.0275735667828541 0.120121273857004 0.858536078495406 0.652173913043478 17.3 17 3 abnormal lens development 0.0275735667828541 0.120121273857004 0.858536078495406 0.652173913043478 17.3 17 3 abnormal basicranium morphology 0.0275735667828541 0.120121273857004 0.858536078495406 0.652173913043478 17.3 17 3 reduced male fertility 1.67530793038707e-11 7.57696086697788e-10 0.858283938677933 0.651982378854626 17.3 17 3 insulin resistance 2.85076335776899e-07 6.50575582793612e-06 0.857668870335309 0.651515151515151 17.3 17 3 abnormal homeostasis 0.00304968612794776 0.0208577020371751 0.857205014807816 0.651162790697674 17.3 17 3 postnatal lethality 1.02725697223166e-08 3.0602415789536e-07 0.856467316860477 0.650602409638554 17.3 17 3 abnormal spatial learning 1.45246130589436e-08 4.12913999818541e-07 0.856078101992556 0.650306748466258 17.3 17 3 male infertility 2.56208181364648e-23 5.31098209287135e-21 0.855805148623452 0.650099403578529 17.3 17 3 decreased circulating phosphate level 0.00441074872931769 0.0286842809520987 0.855674291567088 0.65 17.3 17 3 abnormal basioccipital bone morphology 0.0409755192431479 0.155851076632004 0.855674291567088 0.65 17.3 17 3 abnormal hyoid bone morphology 0.0409755192431479 0.155851076632004 0.855674291567088 0.65 17.3 17 3 absent placental labyrinth 0.0409755192431479 0.155851076632004 0.855674291567088 0.65 17.3 17 3 abnormal male reproductive system physiology 0.0409755192431479 0.155851076632004 0.855674291567088 0.65 17.3 17 3 abnormal response to tactile stimuli 0.0409755192431479 0.155851076632004 0.855674291567088 0.65 17.3 17 3 cleft secondary palate 1.75908066155757e-05 0.000253664530181128 0.854273842644719 0.648936170212766 17.3 17 3 abnormal long bone metaphysis morphology 0.0063935500947144 0.0384970897031211 0.853895342935971 0.648648648648649 17.3 17 3 abnormal breathing pattern 0.0063935500947144 0.0384970897031211 0.853895342935971 0.648648648648649 17.3 17 3 decreased circulating chloride level 0.0063935500947144 0.0384970897031211 0.853895342935971 0.648648648648649 17.3 17 3 decreased circulating HDL cholesterol level 6.14847169908014e-07 1.32418383995341e-05 0.853617382212359 0.6484375 17.3 17 3 abnormal axon morphology 4.64363363254308e-06 7.7523749402355e-05 0.853236473072595 0.648148148148148 17.3 17 3 impaired coordination 3.9887156926764e-16 3.42135527087329e-14 0.85225007252569 0.647398843930636 17.3 17 3 abnormal dendritic spine morphology 0.00156991545240105 0.0120529774316285 0.851802462193481 0.647058823529412 17.3 17 3 decreased susceptibility to injury 0.000278100572515394 0.00277191024940711 0.851802462193481 0.647058823529412 17.3 17 3 lung hemorrhage 0.00929173640542524 0.0513043849817976 0.851802462193481 0.647058823529412 17.3 17 3 increased incidence of corneal inflammation 0.0614109599286531 0.212757329836385 0.851802462193481 0.647058823529412 17.3 17 3 hyperlipidemia 0.0614109599286531 0.212757329836385 0.851802462193481 0.647058823529412 17.3 17 3 abnormal dorsal-ventral axis patterning 0.0614109599286531 0.212757329836385 0.851802462193481 0.647058823529412 17.3 17 3 abnormal involuntary movement 0.0614109599286531 0.212757329836385 0.851802462193481 0.647058823529412 17.3 17 3 abnormal testis development 0.0614109599286531 0.212757329836385 0.851802462193481 0.647058823529412 17.3 17 3 abnormal tarsal bone morphology 0.0614109599286531 0.212757329836385 0.851802462193481 0.647058823529412 17.3 17 3 pancytopenia 0.0614109599286531 0.212757329836385 0.851802462193481 0.647058823529412 17.3 17 3 increased hepatoma incidence 0.0614109599286531 0.212757329836385 0.851802462193481 0.647058823529412 17.3 17 3 abnormal survival 0.0614109599286531 0.212757329836385 0.851802462193481 0.647058823529412 17.3 17 3 abnormal cell cytoskeleton morphology 0.0614109599286531 0.212757329836385 0.851802462193481 0.647058823529412 17.3 17 3 postnatal lethality, incomplete penetrance 2.86946677740273e-25 7.5134722197782e-23 0.850575474011704 0.64612676056338 17.3 17 3 retinal degeneration 1.8835347195106e-05 0.000267731006559006 0.850189199954478 0.645833333333333 17.3 17 3 increased sensitivity to xenobiotic induced morbidity/mortality 4.97057382297737e-06 8.27043637769646e-05 0.849690555262423 0.645454545454546 17.3 17 3 abnormal capillary morphology 0.0135446310559376 0.0707078064042914 0.849304507758896 0.645161290322581 17.3 17 3 decreased thymus weight 0.0135446310559376 0.0707078064042914 0.849304507758896 0.645161290322581 17.3 17 3 preaxial polydactyly 0.0135446310559376 0.0707078064042914 0.849304507758896 0.645161290322581 17.3 17 3 abnormal axial skeleton morphology 0.000145917877378516 0.00161400938128829 0.848745754793265 0.644736842105263 17.3 17 3 hypoactivity 5.04849851170384e-17 4.83005386456281e-15 0.848516028772913 0.644562334217507 17.3 17 3 abnormal ovarian follicle morphology 0.00325273289767213 0.0218090918678152 0.848360836083608 0.644444444444444 17.3 17 3 decreased osteoclast cell number 0.00325273289767213 0.0218090918678152 0.848360836083608 0.644444444444444 17.3 17 3 short limbs 5.39918361505834e-05 0.000671523462122881 0.847352083603128 0.64367816091954 17.3 17 3 female infertility 2.8221930148931e-12 1.39013962862309e-10 0.846271277374043 0.642857142857143 17.3 17 3 enhanced long term potentiation 0.00116438448041784 0.00960665470991501 0.846271277374043 0.642857142857143 17.3 17 3 rib bifurcation 0.019815048578559 0.0937070976029763 0.846271277374043 0.642857142857143 17.3 17 3 shortened head 0.019815048578559 0.0937070976029763 0.846271277374043 0.642857142857143 17.3 17 3 reddish skin 0.019815048578559 0.0937070976029763 0.846271277374043 0.642857142857143 17.3 17 3 abnormal somite shape 0.019815048578559 0.0937070976029763 0.846271277374043 0.642857142857143 17.3 17 3 abnormal hormone level 0.019815048578559 0.0937070976029763 0.846271277374043 0.642857142857143 17.3 17 3 corneal vascularization 0.019815048578559 0.0937070976029763 0.846271277374043 0.642857142857143 17.3 17 3 abnormal renal tubule epithelium morphology 0.019815048578559 0.0937070976029763 0.846271277374043 0.642857142857143 17.3 17 3 abnormal interparietal bone morphology 0.0930951132311332 0.277334244505921 0.846271277374043 0.642857142857143 17.3 17 3 abnormal blood flow velocity 0.0930951132311332 0.277334244505921 0.846271277374043 0.642857142857143 17.3 17 3 translucent skin 0.0930951132311332 0.277334244505921 0.846271277374043 0.642857142857143 17.3 17 3 abnormal antigen presentation 0.0930951132311332 0.277334244505921 0.846271277374043 0.642857142857143 17.3 17 3 abnormal ventral body wall morphology 0.0930951132311332 0.277334244505921 0.846271277374043 0.642857142857143 17.3 17 3 abnormal voluntary movement 0.0930951132311332 0.277334244505921 0.846271277374043 0.642857142857143 17.3 17 3 abnormal decidualization 0.0930951132311332 0.277334244505921 0.846271277374043 0.642857142857143 17.3 17 3 decreased CNS synapse formation 0.0930951132311332 0.277334244505921 0.846271277374043 0.642857142857143 17.3 17 3 premature hair loss 0.0930951132311332 0.277334244505921 0.846271277374043 0.642857142857143 17.3 17 3 abnormal glucose tolerance 0.0930951132311332 0.277334244505921 0.846271277374043 0.642857142857143 17.3 17 3 abnormal vertebrae morphology 7.51103804829552e-06 0.000117456237631093 0.84540861552147 0.642201834862385 17.3 17 3 increased circulating cholesterol level 1.44498414348516e-08 4.12913999818541e-07 0.845202753033924 0.642045454545455 17.3 17 3 decreased circulating glucose level 1.14647302236395e-12 6.06776945346879e-11 0.844586149382458 0.6415770609319 17.3 17 3 abnormal coat/ hair morphology 0.00166943050864084 0.0126393838841166 0.844497123752714 0.641509433962264 17.3 17 3 enlarged kidney 0.00166943050864084 0.0126393838841166 0.844497123752714 0.641509433962264 17.3 17 3 abnormal heart ventricle morphology 0.000155245339873627 0.00167536999104402 0.843860248093775 0.641025641025641 17.3 17 3 abnormal gait 8.94083881115041e-14 5.49144112166337e-12 0.843532535376068 0.640776699029126 17.3 17 3 decreased caudal vertebrae number 0.000603822052445854 0.00549180020277537 0.843332835438716 0.640625 17.3 17 3 decreased eosinophil cell number 0.000603822052445854 0.00549180020277537 0.843332835438716 0.640625 17.3 17 3 kidney inflammation 0.00239619290103094 0.0172768980907666 0.842510071696825 0.64 17.3 17 3 testicular atrophy 0.00239619290103094 0.0172768980907666 0.842510071696825 0.64 17.3 17 3 abnormal thyroid gland morphology 0.029113560181746 0.123689122036026 0.842510071696825 0.64 17.3 17 3 abnormal keratinocyte physiology 0.029113560181746 0.123689122036026 0.842510071696825 0.64 17.3 17 3 decreased placenta weight 0.029113560181746 0.123689122036026 0.842510071696825 0.64 17.3 17 3 increased liver glycogen level 0.029113560181746 0.123689122036026 0.842510071696825 0.64 17.3 17 3 short snout 1.1295948926388e-05 0.000168255526672995 0.841047380600129 0.638888888888889 17.3 17 3 reduced long term depression 0.00982921132779759 0.0539738701498819 0.841047380600129 0.638888888888889 17.3 17 3 abnormal tibia morphology 0.0034435672660857 0.0229190594090736 0.840269353421035 0.638297872340426 17.3 17 3 glomerulosclerosis 0.00123317269627533 0.00995947104540543 0.839786439999529 0.637931034482759 17.3 17 3 limb grasping 1.73096372985478e-08 4.86527941018506e-07 0.839038189533239 0.637362637362637 17.3 17 3 small ovary 6.08323989281958e-05 0.000747262184364875 0.839038189533239 0.637362637362637 17.3 17 3 no abnormal phenotype detected 9.90478419563872e-70 2.46381506866513e-66 0.83841285052683 0.636887608069164 17.3 17 3 omphalocele 0.0049555147545293 0.0317702137935352 0.837723082653093 0.636363636363636 17.3 17 3 abnormal enterocyte morphology 0.0430018063662095 0.162194076324407 0.837723082653093 0.636363636363636 17.3 17 3 abnormal facial nerve morphology 0.0430018063662095 0.162194076324407 0.837723082653093 0.636363636363636 17.3 17 3 abnormal germ layer development 0.0430018063662095 0.162194076324407 0.837723082653093 0.636363636363636 17.3 17 3 testis hypoplasia 0.0430018063662095 0.162194076324407 0.837723082653093 0.636363636363636 17.3 17 3 aphakia 0.0430018063662095 0.162194076324407 0.837723082653093 0.636363636363636 17.3 17 3 abnormal female reproductive system physiology 0.0430018063662095 0.162194076324407 0.837723082653093 0.636363636363636 17.3 17 3 prolonged PR interval 0.0430018063662095 0.162194076324407 0.837723082653093 0.636363636363636 17.3 17 3 abnormal basement membrane morphology 0.0430018063662095 0.162194076324407 0.837723082653093 0.636363636363636 17.3 17 3 cleft upper lip 0.0430018063662095 0.162194076324407 0.837723082653093 0.636363636363636 17.3 17 3 failure of palatal shelf elevation 0.0430018063662095 0.162194076324407 0.837723082653093 0.636363636363636 17.3 17 3 increased bone volume 0.0430018063662095 0.162194076324407 0.837723082653093 0.636363636363636 17.3 17 3 abnormal ear position 0.143429582765987 0.377513447487399 0.837723082653093 0.636363636363636 17.3 17 3 absent semicircular canals 0.143429582765987 0.377513447487399 0.837723082653093 0.636363636363636 17.3 17 3 abnormal stomach epithelium morphology 0.143429582765987 0.377513447487399 0.837723082653093 0.636363636363636 17.3 17 3 abnormal large intestine morphology 0.143429582765987 0.377513447487399 0.837723082653093 0.636363636363636 17.3 17 3 abnormal hypothalamus secretion 0.143429582765987 0.377513447487399 0.837723082653093 0.636363636363636 17.3 17 3 abnormal larynx morphology 0.143429582765987 0.377513447487399 0.837723082653093 0.636363636363636 17.3 17 3 fatigue 0.143429582765987 0.377513447487399 0.837723082653093 0.636363636363636 17.3 17 3 decreased post-tetanic potentiation 0.143429582765987 0.377513447487399 0.837723082653093 0.636363636363636 17.3 17 3 fused joints 0.143429582765987 0.377513447487399 0.837723082653093 0.636363636363636 17.3 17 3 abnormal frequency of paradoxical sleep 0.143429582765987 0.377513447487399 0.837723082653093 0.636363636363636 17.3 17 3 impaired luteinization 0.143429582765987 0.377513447487399 0.837723082653093 0.636363636363636 17.3 17 3 abnormal radial glial cell morphology 0.143429582765987 0.377513447487399 0.837723082653093 0.636363636363636 17.3 17 3 dilated renal glomerular capsule 0.143429582765987 0.377513447487399 0.837723082653093 0.636363636363636 17.3 17 3 cyclopia 0.143429582765987 0.377513447487399 0.837723082653093 0.636363636363636 17.3 17 3 abnormal Bruch membrane morphology 0.143429582765987 0.377513447487399 0.837723082653093 0.636363636363636 17.3 17 3 abnormal aorta smooth muscle morphology 0.143429582765987 0.377513447487399 0.837723082653093 0.636363636363636 17.3 17 3 palatal shelf hypoplasia 0.143429582765987 0.377513447487399 0.837723082653093 0.636363636363636 17.3 17 3 decreased core body temperature 0.143429582765987 0.377513447487399 0.837723082653093 0.636363636363636 17.3 17 3 increased pancreatic beta cell proliferation 0.143429582765987 0.377513447487399 0.837723082653093 0.636363636363636 17.3 17 3 decreased systemic arterial blood pressure 0.0142752630918415 0.0726170080592141 0.837723082653093 0.636363636363636 17.3 17 3 decreased sensitivity to xenobiotic induced morbidity/mortality 0.0142752630918415 0.0726170080592141 0.837723082653093 0.636363636363636 17.3 17 3 abnormal intestine morphology 0.000332254234227337 0.00322844690484571 0.836105856624805 0.635135135135135 17.3 17 3 increased circulating aspartate transaminase level 0.00091051407557047 0.00766464894409998 0.835823483826215 0.634920634920635 17.3 17 3 abnormal skeleton morphology 8.93583460468763e-06 0.000137756509712542 0.835641783068862 0.634782608695652 17.3 17 3 abnormal female meiosis 0.00252673094152413 0.0181917314530862 0.835421645612837 0.634615384615385 17.3 17 3 hypoglycemia 6.42293430508123e-05 0.000783188680582821 0.835149432629581 0.634408602150538 17.3 17 3 abnormal mammary gland development 0.00714220567162937 0.0408889219981083 0.83480418689472 0.634146341463415 17.3 17 3 corneal opacity 0.000472486245276095 0.0044435143104888 0.834351963608211 0.633802816901408 17.3 17 3 abnormal pulmonary alveolus morphology 3.38011733978151e-05 0.000448428900411014 0.834168387818638 0.633663366336634 17.3 17 3 intracranial hemorrhage 0.00129907649305352 0.010440881345624 0.83373392511665 0.633333333333333 17.3 17 3 abnormal long bone epiphyseal plate morphology 0.00129907649305352 0.010440881345624 0.83373392511665 0.633333333333333 17.3 17 3 abnormal response to new environment 0.0207922902645248 0.095779300061121 0.83373392511665 0.633333333333333 17.3 17 3 disorganized myocardium 0.0207922902645248 0.095779300061121 0.83373392511665 0.633333333333333 17.3 17 3 abnormal respiratory system physiology 0.00362194671714759 0.0239935884391601 0.832838399955407 0.63265306122449 17.3 17 3 seizures 1.32855302565587e-05 0.000196129118772639 0.831424412858709 0.631578947368421 17.3 17 3 abnormal facial morphology 0.0018546172115753 0.0138956635957637 0.831424412858709 0.631578947368421 17.3 17 3 enlarged adrenal glands 0.0639358875445836 0.219973057077665 0.831424412858709 0.631578947368421 17.3 17 3 stereotypic behavior 0.0639358875445836 0.219973057077665 0.831424412858709 0.631578947368421 17.3 17 3 unresponsive to tactile stimuli 0.0639358875445836 0.219973057077665 0.831424412858709 0.631578947368421 17.3 17 3 abnormal neural crest cell migration 0.0639358875445836 0.219973057077665 0.831424412858709 0.631578947368421 17.3 17 3 abnormal optic vesicle formation 0.0639358875445836 0.219973057077665 0.831424412858709 0.631578947368421 17.3 17 3 abnormal sternebra morphology 0.0639358875445836 0.219973057077665 0.831424412858709 0.631578947368421 17.3 17 3 decreased circulating magnesium level 0.0639358875445836 0.219973057077665 0.831424412858709 0.631578947368421 17.3 17 3 embryonic lethality between implantation and somite formation, incomplete penetrance 0.0639358875445836 0.219973057077665 0.831424412858709 0.631578947368421 17.3 17 3 increased sensitivity to induced morbidity/mortality 4.23929602111996e-08 1.09846342213916e-06 0.829918209212225 0.630434782608696 17.3 17 3 atrial septal defect 0.00519742240353586 0.0332354453182402 0.829918209212225 0.630434782608696 17.3 17 3 enlarged liver 5.02194704222337e-05 0.000629324597860485 0.829345851826562 0.63 17.3 17 3 impaired limb coordination 0.00264950833043589 0.0190206406117151 0.828858288127663 0.62962962962963 17.3 17 3 increased startle reflex 0.000135211754551488 0.00151163703122169 0.828310463746878 0.629213483146067 17.3 17 3 weight loss 1.17316795949954e-07 2.81957033744455e-06 0.827465248987953 0.628571428571429 17.3 17 3 increased circulating creatinine level 0.000191242581385642 0.00202192198232656 0.826590549993251 0.627906976744186 17.3 17 3 abnormal organ of Corti morphology 0.00746693744120606 0.0424064084132422 0.826590549993251 0.627906976744186 17.3 17 3 abnormal blood circulation 0.00746693744120606 0.0424064084132422 0.826590549993251 0.627906976744186 17.3 17 3 kidney failure 0.00746693744120606 0.0424064084132422 0.826590549993251 0.627906976744186 17.3 17 3 decreased oxygen consumption 0.00746693744120606 0.0424064084132422 0.826590549993251 0.627906976744186 17.3 17 3 abnormal cranium morphology 4.08637854283541e-06 6.91487525530822e-05 0.825219753061256 0.626865671641791 17.3 17 3 abnormal nervous system physiology 2.05687415806218e-05 0.00028988523899035 0.82419463535559 0.626086956521739 17.3 17 3 cachexia 5.49790222465729e-05 0.000682096348320948 0.822763741891431 0.625 17.3 17 3 short mandible 0.00276443938382925 0.0193707878742637 0.822763741891431 0.625 17.3 17 3 abnormal seminal vesicle morphology 0.00276443938382925 0.0193707878742637 0.822763741891431 0.625 17.3 17 3 abnormal intestinal epithelium morphology 0.00541936581571073 0.0346097248256081 0.822763741891431 0.625 17.3 17 3 abnormal lymphatic vessel morphology 0.0216243037787434 0.0988795140618091 0.822763741891431 0.625 17.3 17 3 abnormal depression-related behavior 0.0216243037787434 0.0988795140618091 0.822763741891431 0.625 17.3 17 3 abnormal adrenal gland morphology 0.044589791105682 0.167295784879916 0.822763741891431 0.625 17.3 17 3 abnormal sensory capabilities/reflexes/nociception 0.044589791105682 0.167295784879916 0.822763741891431 0.625 17.3 17 3 abnormal impulse conducting system conduction 0.044589791105682 0.167295784879916 0.822763741891431 0.625 17.3 17 3 hypopigmentation 0.044589791105682 0.167295784879916 0.822763741891431 0.625 17.3 17 3 abnormal inner cell mass apoptosis 0.044589791105682 0.167295784879916 0.822763741891431 0.625 17.3 17 3 abnormal lung saccule morphology 0.044589791105682 0.167295784879916 0.822763741891431 0.625 17.3 17 3 abnormal hair follicle orientation 0.0958715652786012 0.283587910892917 0.822763741891431 0.625 17.3 17 3 disorganized retinal layers 0.0958715652786012 0.283587910892917 0.822763741891431 0.625 17.3 17 3 reduced male mating frequency 0.0958715652786012 0.283587910892917 0.822763741891431 0.625 17.3 17 3 impaired muscle relaxation 0.0958715652786012 0.283587910892917 0.822763741891431 0.625 17.3 17 3 bowed tibia 0.0958715652786012 0.283587910892917 0.822763741891431 0.625 17.3 17 3 abnormal thoracic cage shape 0.0958715652786012 0.283587910892917 0.822763741891431 0.625 17.3 17 3 increased heart left ventricle size 0.0958715652786012 0.283587910892917 0.822763741891431 0.625 17.3 17 3 absent pre-B cells 0.226528897785449 0.458888490322 0.822763741891431 0.625 17.3 17 3 failure of vascular branching 0.226528897785449 0.458888490322 0.822763741891431 0.625 17.3 17 3 pointed snout 0.226528897785449 0.458888490322 0.822763741891431 0.625 17.3 17 3 absent mammary gland 0.226528897785449 0.458888490322 0.822763741891431 0.625 17.3 17 3 increased sensitivity to skin irradiation 0.226528897785449 0.458888490322 0.822763741891431 0.625 17.3 17 3 dermal cysts 0.226528897785449 0.458888490322 0.822763741891431 0.625 17.3 17 3 abnormal urination 0.226528897785449 0.458888490322 0.822763741891431 0.625 17.3 17 3 preneoplasia 0.226528897785449 0.458888490322 0.822763741891431 0.625 17.3 17 3 abnormal pulmonary circulation 0.226528897785449 0.458888490322 0.822763741891431 0.625 17.3 17 3 coarse hair 0.226528897785449 0.458888490322 0.822763741891431 0.625 17.3 17 3 abnormal thyroid physiology 0.226528897785449 0.458888490322 0.822763741891431 0.625 17.3 17 3 joint swelling 0.226528897785449 0.458888490322 0.822763741891431 0.625 17.3 17 3 decreased aerobic running capacity 0.226528897785449 0.458888490322 0.822763741891431 0.625 17.3 17 3 abnormal neuron apoptosis 0.226528897785449 0.458888490322 0.822763741891431 0.625 17.3 17 3 decreased susceptibility to age related obesity 0.226528897785449 0.458888490322 0.822763741891431 0.625 17.3 17 3 abnormal umbilical artery morphology 0.226528897785449 0.458888490322 0.822763741891431 0.625 17.3 17 3 loss of GABAergic neurons 0.226528897785449 0.458888490322 0.822763741891431 0.625 17.3 17 3 abnormal perineum morphology 0.226528897785449 0.458888490322 0.822763741891431 0.625 17.3 17 3 liver cysts 0.226528897785449 0.458888490322 0.822763741891431 0.625 17.3 17 3 decreased circulating renin level 0.226528897785449 0.458888490322 0.822763741891431 0.625 17.3 17 3 abnormal platelet shape 0.226528897785449 0.458888490322 0.822763741891431 0.625 17.3 17 3 increased left ventricle systolic pressure 0.226528897785449 0.458888490322 0.822763741891431 0.625 17.3 17 3 abnormal forelimb zeugopod morphology 0.226528897785449 0.458888490322 0.822763741891431 0.625 17.3 17 3 lymph node inflammation 0.226528897785449 0.458888490322 0.822763741891431 0.625 17.3 17 3 abnormal skin development 0.226528897785449 0.458888490322 0.822763741891431 0.625 17.3 17 3 long femur 0.226528897785449 0.458888490322 0.822763741891431 0.625 17.3 17 3 bowed fibula 0.226528897785449 0.458888490322 0.822763741891431 0.625 17.3 17 3 absent cochlear microphonics 0.226528897785449 0.458888490322 0.822763741891431 0.625 17.3 17 3 abnormal vestibular labyrinth morphology 0.226528897785449 0.458888490322 0.822763741891431 0.625 17.3 17 3 non-pigmented tail tip 0.226528897785449 0.458888490322 0.822763741891431 0.625 17.3 17 3 abnormal canal of Schlemm morphology 0.226528897785449 0.458888490322 0.822763741891431 0.625 17.3 17 3 abnormal vertebral body development 0.226528897785449 0.458888490322 0.822763741891431 0.625 17.3 17 3 ectrodactyly 0.226528897785449 0.458888490322 0.822763741891431 0.625 17.3 17 3 ocular hypertension 0.226528897785449 0.458888490322 0.822763741891431 0.625 17.3 17 3 decreased susceptibility to autoimmune disorder 0.226528897785449 0.458888490322 0.822763741891431 0.625 17.3 17 3 stomach epithelial hyperplasia 0.226528897785449 0.458888490322 0.822763741891431 0.625 17.3 17 3 choroidal neovascularization 0.226528897785449 0.458888490322 0.822763741891431 0.625 17.3 17 3 impaired behavioral response to alcohol 0.226528897785449 0.458888490322 0.822763741891431 0.625 17.3 17 3 abnormal sphingomyelin level 0.226528897785449 0.458888490322 0.822763741891431 0.625 17.3 17 3 abnormal lateral plate mesoderm morphology 0.226528897785449 0.458888490322 0.822763741891431 0.625 17.3 17 3 abnormal hepatic vein morphology 0.226528897785449 0.458888490322 0.822763741891431 0.625 17.3 17 3 myocardial trabeculae hypoplasia 0.226528897785449 0.458888490322 0.822763741891431 0.625 17.3 17 3 increased heart right ventricle size 0.226528897785449 0.458888490322 0.822763741891431 0.625 17.3 17 3 abnormal visual evoked potential 0.226528897785449 0.458888490322 0.822763741891431 0.625 17.3 17 3 abnormal anterior commissure pars posterior morphology 0.226528897785449 0.458888490322 0.822763741891431 0.625 17.3 17 3 abnormal bronchiole epithelium morphology 0.226528897785449 0.458888490322 0.822763741891431 0.625 17.3 17 3 lethality during fetal growth through weaning, incomplete penetrance 0.226528897785449 0.458888490322 0.822763741891431 0.625 17.3 17 3 impaired neuron differentiation 0.226528897785449 0.458888490322 0.822763741891431 0.625 17.3 17 3 decreased cranium length 0.226528897785449 0.458888490322 0.822763741891431 0.625 17.3 17 3 abnormal heart echocardiography feature 0.226528897785449 0.458888490322 0.822763741891431 0.625 17.3 17 3 increased testis apoptosis 0.226528897785449 0.458888490322 0.822763741891431 0.625 17.3 17 3 respiratory distress 2.52481035383679e-07 5.78844770061659e-06 0.821812569935487 0.624277456647399 17.3 17 3 abnormal cardiovascular system physiology 5.99697666321638e-06 9.84652108894439e-05 0.821526503181819 0.62406015037594 17.3 17 3 cardiac fibrosis 0.000282117131038265 0.00279032351275421 0.820827827204627 0.623529411764706 17.3 17 3 abnormal long bone morphology 0.0020202304890202 0.0149786090653882 0.820066155852442 0.622950819672131 17.3 17 3 cardiac hypertrophy 0.000109057301356513 0.00124440384001985 0.819405522536772 0.622448979591837 17.3 17 3 abnormal metabolism 0.00776009663641172 0.0440210727094051 0.819107014149691 0.622222222222222 17.3 17 3 increased circulating phosphate level 0.0154735119250057 0.0759178716241651 0.818316370313639 0.621621621621622 17.3 17 3 decreased width of hypertrophic chondrocyte zone 0.0154735119250057 0.0759178716241651 0.818316370313639 0.621621621621622 17.3 17 3 abnormal humerus morphology 0.0154735119250057 0.0759178716241651 0.818316370313639 0.621621621621622 17.3 17 3 abnormal middle ear morphology 0.0314287640529554 0.132059207063727 0.817089509188731 0.620689655172414 17.3 17 3 abnormal spinal nerve morphology 0.0314287640529554 0.132059207063727 0.817089509188731 0.620689655172414 17.3 17 3 enlarged epididymis 0.0314287640529554 0.132059207063727 0.817089509188731 0.620689655172414 17.3 17 3 decreased respiratory quotient 0.00562186083818005 0.0351366302386253 0.816181631956299 0.62 17.3 17 3 abnormal pancreas morphology 0.0111216537872116 0.0596874084049381 0.81492789673056 0.619047619047619 17.3 17 3 abnormal clavicle morphology 0.0657498135266327 0.225434405441074 0.81492789673056 0.619047619047619 17.3 17 3 complete atrioventricular septal defect 0.0657498135266327 0.225434405441074 0.81492789673056 0.619047619047619 17.3 17 3 vascular ring 0.0657498135266327 0.225434405441074 0.81492789673056 0.619047619047619 17.3 17 3 abnormal retina morphology 3.33357397047811e-08 8.86873288937357e-07 0.81492789673056 0.619047619047619 17.3 17 3 abnormal vision 0.022325575431437 0.101805442503574 0.813084168457414 0.617647058823529 17.3 17 3 decreased osteoblast cell number 0.022325575431437 0.101805442503574 0.813084168457414 0.617647058823529 17.3 17 3 hepatic necrosis 0.00802307790276112 0.0449491132502664 0.812260374973668 0.617021276595745 17.3 17 3 abnormal motor coordination/ balance 0.000164995777391266 0.00177674024355313 0.811128699076804 0.616161616161616 17.3 17 3 reduced long term potentiation 6.40267177319688e-05 0.00078263616883672 0.811009974150124 0.616071428571429 17.3 17 3 decreased litter size 3.68273722494194e-10 1.33734435723257e-08 0.810466205535758 0.615658362989324 17.3 17 3 absent corpus luteum 0.00580555749550538 0.0357901468898876 0.810105838170024 0.615384615384615 17.3 17 3 eyelids open at birth 0.00580555749550538 0.0357901468898876 0.810105838170024 0.615384615384615 17.3 17 3 abnormal brain wave pattern 0.00580555749550538 0.0357901468898876 0.810105838170024 0.615384615384615 17.3 17 3 increased susceptibility to injury 0.00580555749550538 0.0357901468898876 0.810105838170024 0.615384615384615 17.3 17 3 abnormal nerve conduction 0.0458114906824382 0.171620607036995 0.810105838170024 0.615384615384615 17.3 17 3 short premaxilla 0.145394733566046 0.377513447487399 0.810105838170024 0.615384615384615 17.3 17 3 abnormal mast cell morphology 0.145394733566046 0.377513447487399 0.810105838170024 0.615384615384615 17.3 17 3 abnormal renal/urinary system morphology 0.145394733566046 0.377513447487399 0.810105838170024 0.615384615384615 17.3 17 3 uterus hypoplasia 0.145394733566046 0.377513447487399 0.810105838170024 0.615384615384615 17.3 17 3 excessive scratching 0.145394733566046 0.377513447487399 0.810105838170024 0.615384615384615 17.3 17 3 abnormal digestion 0.145394733566046 0.377513447487399 0.810105838170024 0.615384615384615 17.3 17 3 abnormal bile duct development 0.145394733566046 0.377513447487399 0.810105838170024 0.615384615384615 17.3 17 3 abnormal soleus morphology 0.145394733566046 0.377513447487399 0.810105838170024 0.615384615384615 17.3 17 3 axonal dystrophy 0.145394733566046 0.377513447487399 0.810105838170024 0.615384615384615 17.3 17 3 tracheoesophageal fistula 0.145394733566046 0.377513447487399 0.810105838170024 0.615384615384615 17.3 17 3 abnormal vestibulocochlear ganglion morphology 0.145394733566046 0.377513447487399 0.810105838170024 0.615384615384615 17.3 17 3 abnormal retinal inner plexiform layer morphology 0.145394733566046 0.377513447487399 0.810105838170024 0.615384615384615 17.3 17 3 increased circulating thyroid-stimulating hormone level 0.145394733566046 0.377513447487399 0.810105838170024 0.615384615384615 17.3 17 3 increased circulating ammonia level 0.145394733566046 0.377513447487399 0.810105838170024 0.615384615384615 17.3 17 3 increased circulating thyroxine level 0.145394733566046 0.377513447487399 0.810105838170024 0.615384615384615 17.3 17 3 short tail 0.000602114683389083 0.00549180020277537 0.808885799257117 0.614457831325301 17.3 17 3 microphthalmia 3.97435719865211e-06 6.79638302283774e-05 0.808782135820073 0.61437908496732 17.3 17 3 abnormal blood homeostasis 6.61650579033424e-05 0.000804819469606671 0.8083292902793 0.614035087719298 17.3 17 3 postnatal lethality, complete penetrance 3.45241080071414e-13 1.92985884646661e-11 0.808269458355519 0.613989637305699 17.3 17 3 abnormal motor capabilities/coordination/movement 1.90846007838148e-05 0.000270501107975723 0.807804401129768 0.613636363636364 17.3 17 3 hyperglycemia 0.000442005362938034 0.00421259900501287 0.807804401129768 0.613636363636364 17.3 17 3 cochlear hair cell degeneration 0.0114556675906339 0.0614137351976332 0.807804401129768 0.613636363636364 17.3 17 3 abnormal limb morphology 0.00115636949609046 0.00955637581902001 0.807405485376124 0.613333333333333 17.3 17 3 absent mature ovarian follicles 0.0322677506781213 0.135355868148106 0.806839282370951 0.612903225806452 17.3 17 3 abnormal intestine physiology 0.0322677506781213 0.135355868148106 0.806839282370951 0.612903225806452 17.3 17 3 abnormal retinal pigment epithelium morphology 0.000846627338915559 0.00722465010481116 0.806308467053602 0.6125 17.3 17 3 polydactyly 0.000238791609916783 0.00243940094319506 0.805972645118136 0.612244897959184 17.3 17 3 abnormal lung development 0.000620553587583111 0.00563367536172623 0.8053405097102 0.611764705882353 17.3 17 3 abnormal kidney morphology 1.23628354141467e-06 2.47008458575822e-05 0.804898014924645 0.611428571428571 17.3 17 3 abnormal mandible morphology 0.00597119830989617 0.0365846201868639 0.804480103182732 0.611111111111111 17.3 17 3 impaired wound healing 0.0229095682065633 0.104181994358 0.804480103182732 0.611111111111111 17.3 17 3 narrow eye opening 0.0229095682065633 0.104181994358 0.804480103182732 0.611111111111111 17.3 17 3 abnormal retinal blood vessel morphology 0.0229095682065633 0.104181994358 0.804480103182732 0.611111111111111 17.3 17 3 thick dermal layer 0.0975334053909907 0.286778186654952 0.804480103182732 0.611111111111111 17.3 17 3 blepharoptosis 0.0975334053909907 0.286778186654952 0.804480103182732 0.611111111111111 17.3 17 3 abnormal iron level 0.0975334053909907 0.286778186654952 0.804480103182732 0.611111111111111 17.3 17 3 eye inflammation 0.0975334053909907 0.286778186654952 0.804480103182732 0.611111111111111 17.3 17 3 abnormal bile duct morphology 0.0975334053909907 0.286778186654952 0.804480103182732 0.611111111111111 17.3 17 3 increased circulating renin level 0.0975334053909907 0.286778186654952 0.804480103182732 0.611111111111111 17.3 17 3 jerky movement 0.0975334053909907 0.286778186654952 0.804480103182732 0.611111111111111 17.3 17 3 abnormal sperm axoneme morphology 0.0975334053909907 0.286778186654952 0.804480103182732 0.611111111111111 17.3 17 3 increased circulating glucose level 1.49827544447863e-05 0.000219232951067093 0.802924048824545 0.609929078014184 17.3 17 3 scaly skin 0.0163648897003758 0.0798189473131074 0.802696333552615 0.609756097560976 17.3 17 3 abnormal retinal pigmentation 0.000638038268957771 0.00577048816292552 0.801958221981532 0.609195402298851 17.3 17 3 fragile skeleton 0.0670012901625404 0.228592813062913 0.801300339929045 0.608695652173913 17.3 17 3 abnormal blood vessel physiology 0.0670012901625404 0.228592813062913 0.801300339929045 0.608695652173913 17.3 17 3 abnormal postnatal growth 0.0670012901625404 0.228592813062913 0.801300339929045 0.608695652173913 17.3 17 3 conjunctivitis 0.0670012901625404 0.228592813062913 0.801300339929045 0.608695652173913 17.3 17 3 abnormal ulna morphology 0.0670012901625404 0.228592813062913 0.801300339929045 0.608695652173913 17.3 17 3 abnormal palatal shelf fusion at midline 0.0670012901625404 0.228592813062913 0.801300339929045 0.608695652173913 17.3 17 3 kidney cysts 0.00167170142628115 0.0126393838841166 0.800526884002473 0.608108108108108 17.3 17 3 abnormal gluconeogenesis 0.00846462711696945 0.0471573571186148 0.800178070545391 0.607843137254902 17.3 17 3 abnormal ovulation 0.0467263488055304 0.174522211191827 0.799256206408818 0.607142857142857 17.3 17 3 abnormal respiration 0.0467263488055304 0.174522211191827 0.799256206408818 0.607142857142857 17.3 17 3 prolonged QRS complex duration 0.0467263488055304 0.174522211191827 0.799256206408818 0.607142857142857 17.3 17 3 abnormal skeletal muscle fiber morphology 0.00234721139954284 0.0170971840596276 0.797269654114513 0.605633802816901 17.3 17 3 neonatal lethality, complete penetrance 4.89510499850923e-14 3.12219838045941e-12 0.796781728989596 0.605263157894737 17.3 17 3 hyporesponsive to tactile stimuli 0.0233886134628481 0.106166379541669 0.796781728989596 0.605263157894737 17.3 17 3 abnormal male reproductive system morphology 0.0167112199634553 0.0814283245036144 0.795976085178686 0.604651162790698 17.3 17 3 increased thermal nociceptive threshold 0.000670132247286548 0.00597235465456368 0.795639662488416 0.604395604395604 17.3 17 3 abnormal phalanx morphology 0.0119971647724695 0.0639035275621368 0.795338283828383 0.604166666666667 17.3 17 3 cochlear ganglion degeneration 0.00625155794713575 0.0382082319250619 0.794392578377933 0.603448275862069 17.3 17 3 abnormal enzyme/coenzyme level 0.00625155794713575 0.0382082319250619 0.794392578377933 0.603448275862069 17.3 17 3 absent gastric milk in neonates 0.00174931496311216 0.0132061334468634 0.793228633208148 0.602564102564103 17.3 17 3 lethargy 0.000684746866596015 0.00599756278400559 0.792684207241636 0.602150537634409 17.3 17 3 decreased heart rate 0.000512154633816184 0.00478941598352541 0.789853192215773 0.6 17.3 17 3 increased circulating calcium level 0.00880419678750673 0.0488304113911327 0.789853192215773 0.6 17.3 17 3 increased body length 0.0122106986710718 0.0646584875897159 0.789853192215773 0.6 17.3 17 3 abnormal axon extension 0.0122106986710718 0.0646584875897159 0.789853192215773 0.6 17.3 17 3 abnormal autopod morphology 0.0169990240219671 0.0826687629611791 0.789853192215773 0.6 17.3 17 3 irregular heartbeat 0.0169990240219671 0.0826687629611791 0.789853192215773 0.6 17.3 17 3 abnormal female reproductive system morphology 0.0237739022318726 0.106939569261814 0.789853192215773 0.6 17.3 17 3 impaired ovarian folliculogenesis 0.0237739022318726 0.106939569261814 0.789853192215773 0.6 17.3 17 3 abnormal pancreatic beta cell morphology 0.0237739022318726 0.106939569261814 0.789853192215773 0.6 17.3 17 3 abnormal nest building behavior 0.067804137491586 0.231044920562083 0.789853192215773 0.6 17.3 17 3 decreased muscle cell glucose uptake 0.098376439996737 0.28772728991563 0.789853192215773 0.6 17.3 17 3 increased cranium width 0.224010922944693 0.458888490322 0.789853192215773 0.6 17.3 17 3 abnormal prostate gland epithelium morphology 0.224010922944693 0.458888490322 0.789853192215773 0.6 17.3 17 3 decreased incidence of induced tumors 0.224010922944693 0.458888490322 0.789853192215773 0.6 17.3 17 3 abnormal gland morphology 0.224010922944693 0.458888490322 0.789853192215773 0.6 17.3 17 3 impaired social transmission of food preference 0.224010922944693 0.458888490322 0.789853192215773 0.6 17.3 17 3 abnormal primordial germ cell migration 0.224010922944693 0.458888490322 0.789853192215773 0.6 17.3 17 3 abnormal bone healing 0.224010922944693 0.458888490322 0.789853192215773 0.6 17.3 17 3 acrania 0.224010922944693 0.458888490322 0.789853192215773 0.6 17.3 17 3 aneurysm 0.224010922944693 0.458888490322 0.789853192215773 0.6 17.3 17 3 absent seminal vesicle 0.224010922944693 0.458888490322 0.789853192215773 0.6 17.3 17 3 increased atrioventricular cushion size 0.224010922944693 0.458888490322 0.789853192215773 0.6 17.3 17 3 increased left ventricle diastolic pressure 0.224010922944693 0.458888490322 0.789853192215773 0.6 17.3 17 3 abnormal pillar cell morphology 0.224010922944693 0.458888490322 0.789853192215773 0.6 17.3 17 3 abnormal hindlimb zeugopod morphology 0.224010922944693 0.458888490322 0.789853192215773 0.6 17.3 17 3 increased heart rate variability 0.224010922944693 0.458888490322 0.789853192215773 0.6 17.3 17 3 abnormal reproductive system development 0.224010922944693 0.458888490322 0.789853192215773 0.6 17.3 17 3 abnormal utricular macula morphology 0.224010922944693 0.458888490322 0.789853192215773 0.6 17.3 17 3 decreased cochlear inner hair cell number 0.224010922944693 0.458888490322 0.789853192215773 0.6 17.3 17 3 abnormal cochlear inner hair cell physiology 0.224010922944693 0.458888490322 0.789853192215773 0.6 17.3 17 3 absent coat pigmentation 0.224010922944693 0.458888490322 0.789853192215773 0.6 17.3 17 3 vascular smooth muscle hyperplasia 0.224010922944693 0.458888490322 0.789853192215773 0.6 17.3 17 3 abnormal developmental vascular remodeling 0.224010922944693 0.458888490322 0.789853192215773 0.6 17.3 17 3 protruding tongue 0.224010922944693 0.458888490322 0.789853192215773 0.6 17.3 17 3 increased serotonin level 0.224010922944693 0.458888490322 0.789853192215773 0.6 17.3 17 3 increased kidney iron level 0.224010922944693 0.458888490322 0.789853192215773 0.6 17.3 17 3 abnormal heart and great artery attachment 0.224010922944693 0.458888490322 0.789853192215773 0.6 17.3 17 3 common ventricle 0.224010922944693 0.458888490322 0.789853192215773 0.6 17.3 17 3 aorta stenosis 0.224010922944693 0.458888490322 0.789853192215773 0.6 17.3 17 3 decreased circulating thyroxine level 0.0334399134076164 0.137322152244328 0.789853192215773 0.6 17.3 17 3 absent incisors 0.145769514095134 0.377513447487399 0.789853192215773 0.6 17.3 17 3 abnormal pup retrieval 0.145769514095134 0.377513447487399 0.789853192215773 0.6 17.3 17 3 audiogenic seizures 0.145769514095134 0.377513447487399 0.789853192215773 0.6 17.3 17 3 absent egg cylinders 0.145769514095134 0.377513447487399 0.789853192215773 0.6 17.3 17 3 placental labyrinth hypoplasia 0.145769514095134 0.377513447487399 0.789853192215773 0.6 17.3 17 3 abnormal glial cell morphology 0.145769514095134 0.377513447487399 0.789853192215773 0.6 17.3 17 3 abnormal olfactory nerve morphology 0.145769514095134 0.377513447487399 0.789853192215773 0.6 17.3 17 3 abnormal zygomatic bone morphology 0.145769514095134 0.377513447487399 0.789853192215773 0.6 17.3 17 3 abnormal secondary palate development 0.145769514095134 0.377513447487399 0.789853192215773 0.6 17.3 17 3 abnormal aorta wall morphology 0.145769514095134 0.377513447487399 0.789853192215773 0.6 17.3 17 3 abnormal branching involved in lung morphogenesis 0.145769514095134 0.377513447487399 0.789853192215773 0.6 17.3 17 3 maternal effect 0.00469412681098512 0.0303683756627451 0.785923574344053 0.597014925373134 17.3 17 3 abnormal trabecular bone morphology 0.000210512341288296 0.00219100187847128 0.785428244360223 0.596638655462185 17.3 17 3 hydronephrosis 0.00184320433149329 0.0138309827287769 0.783584516087077 0.595238095238095 17.3 17 3 arrest of spermatogenesis 0.00184320433149329 0.0138309827287769 0.783584516087077 0.595238095238095 17.3 17 3 impaired skeletal muscle contractility 0.0338157840861807 0.137322152244328 0.782737397691307 0.594594594594595 17.3 17 3 abnormal pancreatic beta cell physiology 0.0338157840861807 0.137322152244328 0.782737397691307 0.594594594594595 17.3 17 3 polydipsia 0.0478235576849038 0.175977958197039 0.781625554796859 0.59375 17.3 17 3 increased circulating follicle stimulating hormone level 0.0478235576849038 0.175977958197039 0.781625554796859 0.59375 17.3 17 3 abnormal heart atrium morphology 0.0478235576849038 0.175977958197039 0.781625554796859 0.59375 17.3 17 3 bradykinesia 0.0478235576849038 0.175977958197039 0.781625554796859 0.59375 17.3 17 3 abnormal skeleton development 0.00255854117537347 0.0183941363402934 0.780101918237801 0.592592592592593 17.3 17 3 abnormal chondrocyte morphology 0.0125375199712024 0.066004404081198 0.780101918237801 0.592592592592593 17.3 17 3 abnormal neuronal precursor proliferation 0.0125375199712024 0.066004404081198 0.780101918237801 0.592592592592593 17.3 17 3 abnormal type II pneumocyte morphology 0.0682466115350055 0.231798152482924 0.780101918237801 0.592592592592593 17.3 17 3 decreased susceptibility to pharmacologically induced seizures 0.0682466115350055 0.231798152482924 0.780101918237801 0.592592592592593 17.3 17 3 abnormal skin appearance 0.0682466115350055 0.231798152482924 0.780101918237801 0.592592592592593 17.3 17 3 abnormal epidermis stratum corneum morphology 0.017419829534112 0.0842212360857215 0.779106890280865 0.591836734693878 17.3 17 3 abnormal craniofacial development 0.017419829534112 0.0842212360857215 0.779106890280865 0.591836734693878 17.3 17 3 decreased liver weight 0.00481880764637051 0.0311345039489523 0.778728499367664 0.591549295774648 17.3 17 3 renal interstitial fibrosis 0.0243025733908642 0.109021913994183 0.777885719606443 0.590909090909091 17.3 17 3 abnormal basisphenoid bone morphology 0.0986080460916883 0.28772728991563 0.777885719606443 0.590909090909091 17.3 17 3 abnormal oogenesis 0.0986080460916883 0.28772728991563 0.777885719606443 0.590909090909091 17.3 17 3 parakeratosis 0.0986080460916883 0.28772728991563 0.777885719606443 0.590909090909091 17.3 17 3 abnormal temporal bone morphology 0.0986080460916883 0.28772728991563 0.777885719606443 0.590909090909091 17.3 17 3 increased circulating creatine kinase level 0.0986080460916883 0.28772728991563 0.777885719606443 0.590909090909091 17.3 17 3 impaired swimming 0.00663231727062355 0.0388508815551426 0.777885719606443 0.590909090909091 17.3 17 3 hyperactivity 4.90511334605036e-10 1.75560711486335e-08 0.777079286142203 0.590296495956873 17.3 17 3 abnormal maternal nurturing 0.00914946975131654 0.050632493896329 0.776904779228629 0.590163934426229 17.3 17 3 abnormal cornea morphology 0.00354696057535755 0.0235595845959997 0.776351428246273 0.58974358974359 17.3 17 3 small lens 0.0340753786626167 0.137322152244328 0.776351428246273 0.58974358974359 17.3 17 3 abnormal iris morphology 0.0340753786626167 0.137322152244328 0.776351428246273 0.58974358974359 17.3 17 3 acanthosis 0.0340753786626167 0.137322152244328 0.776351428246273 0.58974358974359 17.3 17 3 increased or absent threshold for auditory brainstem response 5.64712471333347e-08 1.41891138630475e-06 0.774365874721346 0.588235294117647 17.3 17 3 distended abdomen 0.0175622294626464 0.0847449966795984 0.774365874721346 0.588235294117647 17.3 17 3 increased width of hypertrophic chondrocyte zone 0.0480804413468363 0.176385153442403 0.774365874721346 0.588235294117647 17.3 17 3 abnormal nervous system development 0.0480804413468363 0.176385153442403 0.774365874721346 0.588235294117647 17.3 17 3 abnormal skin physiology 0.0480804413468363 0.176385153442403 0.774365874721346 0.588235294117647 17.3 17 3 abnormal cranial suture morphology 0.145101001492813 0.377513447487399 0.774365874721346 0.588235294117647 17.3 17 3 delayed heart development 0.145101001492813 0.377513447487399 0.774365874721346 0.588235294117647 17.3 17 3 decreased body fat mass 0.145101001492813 0.377513447487399 0.774365874721346 0.588235294117647 17.3 17 3 abnormal hair follicle morphology 0.00922661793183575 0.0510026935676476 0.773136722539249 0.587301587301587 17.3 17 3 abnormal forelimb morphology 0.0244631672656094 0.109643474906673 0.772682470645865 0.58695652173913 17.3 17 3 improved glucose tolerance 8.6436710667841e-06 0.000133963437873056 0.772390451571547 0.586734693877551 17.3 17 3 increased circulating triglyceride level 0.000126474411662248 0.00143002317731746 0.771695647567135 0.586206896551724 17.3 17 3 aphagia 0.0683979272050116 0.231798152482924 0.771695647567135 0.586206896551724 17.3 17 3 absent long term depression 0.0683979272050116 0.231798152482924 0.771695647567135 0.586206896551724 17.3 17 3 thick epidermis 0.00674601027034789 0.0391614948599542 0.771047163829683 0.585714285714286 17.3 17 3 abnormal response/metabolism to endogenous compounds 0.00360852606251869 0.0239365562147073 0.770588480210511 0.585365853658537 17.3 17 3 hemopericardium 0.0342336846292796 0.137322152244328 0.770588480210511 0.585365853658537 17.3 17 3 heart right ventricle hypertrophy 0.0481823966890906 0.176385153442403 0.767912825765335 0.583333333333333 17.3 17 3 abnormal limb bone morphology 0.0481823966890906 0.176385153442403 0.767912825765335 0.583333333333333 17.3 17 3 renal hypoplasia 0.0481823966890906 0.176385153442403 0.767912825765335 0.583333333333333 17.3 17 3 abnormal body weight 0.0983773888421421 0.28772728991563 0.767912825765335 0.583333333333333 17.3 17 3 abnormal primitive streak formation 0.0983773888421421 0.28772728991563 0.767912825765335 0.583333333333333 17.3 17 3 prolonged QT interval 0.0983773888421421 0.28772728991563 0.767912825765335 0.583333333333333 17.3 17 3 abnormal retinal ganglion layer morphology 0.0983773888421421 0.28772728991563 0.767912825765335 0.583333333333333 17.3 17 3 abnormal mineral level 0.219954411755678 0.458888490322 0.767912825765335 0.583333333333333 17.3 17 3 abnormal superior cervical ganglion morphology 0.219954411755678 0.458888490322 0.767912825765335 0.583333333333333 17.3 17 3 abnormal enteric nervous system morphology 0.219954411755678 0.458888490322 0.767912825765335 0.583333333333333 17.3 17 3 abnormal pilomotor reflex 0.219954411755678 0.458888490322 0.767912825765335 0.583333333333333 17.3 17 3 abnormal corticospinal tract morphology 0.219954411755678 0.458888490322 0.767912825765335 0.583333333333333 17.3 17 3 abnormal AMPA-mediated synaptic currents 0.219954411755678 0.458888490322 0.767912825765335 0.583333333333333 17.3 17 3 increased circulating parathyroid hormone level 0.219954411755678 0.458888490322 0.767912825765335 0.583333333333333 17.3 17 3 small thyroid gland 0.219954411755678 0.458888490322 0.767912825765335 0.583333333333333 17.3 17 3 abnormal alisphenoid bone morphology 0.219954411755678 0.458888490322 0.767912825765335 0.583333333333333 17.3 17 3 loss of dopaminergic neurons 0.219954411755678 0.458888490322 0.767912825765335 0.583333333333333 17.3 17 3 dilated bile duct 0.219954411755678 0.458888490322 0.767912825765335 0.583333333333333 17.3 17 3 increased hepatocyte proliferation 0.219954411755678 0.458888490322 0.767912825765335 0.583333333333333 17.3 17 3 stria vascularis degeneration 0.219954411755678 0.458888490322 0.767912825765335 0.583333333333333 17.3 17 3 decreased cochlear nerve compound action potential 0.219954411755678 0.458888490322 0.767912825765335 0.583333333333333 17.3 17 3 small parietal bone 0.219954411755678 0.458888490322 0.767912825765335 0.583333333333333 17.3 17 3 hemoperitoneum 0.219954411755678 0.458888490322 0.767912825765335 0.583333333333333 17.3 17 3 hydrometra 0.219954411755678 0.458888490322 0.767912825765335 0.583333333333333 17.3 17 3 abnormal contextual conditioning behavior 0.0177317087485183 0.0854798944029831 0.765918246997114 0.581818181818182 17.3 17 3 decreased startle reflex 0.00079134987089801 0.00678787173744414 0.765099958271689 0.581196581196581 17.3 17 3 abnormal eyelid morphology 0.0683129388151889 0.231798152482924 0.764374056983006 0.580645161290323 17.3 17 3 abnormal postnatal growth/weight/body size 0.0683129388151889 0.231798152482924 0.764374056983006 0.580645161290323 17.3 17 3 abnormal nose morphology 0.0683129388151889 0.231798152482924 0.764374056983006 0.580645161290323 17.3 17 3 abnormal hindlimb morphology 0.0246133912021201 0.110127254214646 0.763524752475248 0.58 17.3 17 3 short femur 0.00366503184812591 0.0242467200058862 0.762926378844781 0.579545454545455 17.3 17 3 alopecia 0.00269563370566178 0.0193238871551403 0.762139045120483 0.578947368421053 17.3 17 3 abnormal circulating amino acid level 0.0177660281792289 0.0855624300016109 0.762139045120483 0.578947368421053 17.3 17 3 increased susceptibility to ischemic brain injury 0.143729992429801 0.377513447487399 0.762139045120483 0.578947368421053 17.3 17 3 osteoarthritis 0.143729992429801 0.377513447487399 0.762139045120483 0.578947368421053 17.3 17 3 increased left ventricle weight 0.143729992429801 0.377513447487399 0.762139045120483 0.578947368421053 17.3 17 3 decreased eye pigmentation 0.143729992429801 0.377513447487399 0.762139045120483 0.578947368421053 17.3 17 3 Leydig cell hypoplasia 0.143729992429801 0.377513447487399 0.762139045120483 0.578947368421053 17.3 17 3 decreased fertilization frequency 0.143729992429801 0.377513447487399 0.762139045120483 0.578947368421053 17.3 17 3 increased liver cholesterol level 0.143729992429801 0.377513447487399 0.762139045120483 0.578947368421053 17.3 17 3 decreased liver glycogen level 0.143729992429801 0.377513447487399 0.762139045120483 0.578947368421053 17.3 17 3 abnormal myocardial fiber morphology 0.00270290711943365 0.0193481480851545 0.759996198695589 0.577319587628866 17.3 17 3 decreased kidney weight 0.0246153782284797 0.110127254214646 0.759474223284398 0.576923076923077 17.3 17 3 abnormal xiphoid process morphology 0.0977941104131518 0.287035810799664 0.759474223284398 0.576923076923077 17.3 17 3 abnormal Schwann cell morphology 0.0977941104131518 0.287035810799664 0.759474223284398 0.576923076923077 17.3 17 3 thick skin 0.0977941104131518 0.287035810799664 0.759474223284398 0.576923076923077 17.3 17 3 increased body weight 9.40779790342121e-06 0.000144456156078767 0.758118019314247 0.575892857142857 17.3 17 3 increased circulating insulin level 0.000180136814141333 0.0019355953571342 0.756942642540116 0.575 17.3 17 3 perinatal lethality 0.0480126703042119 0.176385153442403 0.756942642540116 0.575 17.3 17 3 cyanosis 5.52936716996631e-05 0.000684293573895084 0.754200096733811 0.572916666666667 17.3 17 3 abnormal lung morphology 0.0014720831549819 0.0114431464000546 0.752241135443594 0.571428571428571 17.3 17 3 impaired fertilization 0.0128511893709239 0.0672996496003648 0.752241135443594 0.571428571428571 17.3 17 3 organ of Corti degeneration 0.0340909591437292 0.137322152244328 0.752241135443594 0.571428571428571 17.3 17 3 increased fluid intake 0.0340909591437292 0.137322152244328 0.752241135443594 0.571428571428571 17.3 17 3 myoclonus 0.096940295174306 0.286388342335019 0.752241135443594 0.571428571428571 17.3 17 3 absent corpus callosum 0.096940295174306 0.286388342335019 0.752241135443594 0.571428571428571 17.3 17 3 abnormal salivary gland morphology 0.141878608623543 0.377513447487399 0.752241135443594 0.571428571428571 17.3 17 3 dry skin 0.141878608623543 0.377513447487399 0.752241135443594 0.571428571428571 17.3 17 3 abnormal embryonic/fetal subventricular zone morphology 0.141878608623543 0.377513447487399 0.752241135443594 0.571428571428571 17.3 17 3 increased bone ossification 0.141878608623543 0.377513447487399 0.752241135443594 0.571428571428571 17.3 17 3 absent atrioventricular cushions 0.215127560679263 0.458888490322 0.752241135443594 0.571428571428571 17.3 17 3 decreased coping response 0.215127560679263 0.458888490322 0.752241135443594 0.571428571428571 17.3 17 3 decreased vascular permeability 0.215127560679263 0.458888490322 0.752241135443594 0.571428571428571 17.3 17 3 intestinal obstruction 0.215127560679263 0.458888490322 0.752241135443594 0.571428571428571 17.3 17 3 abnormal pancreas development 0.215127560679263 0.458888490322 0.752241135443594 0.571428571428571 17.3 17 3 sternebra fusion 0.215127560679263 0.458888490322 0.752241135443594 0.571428571428571 17.3 17 3 abnormal neuromuscular synapse morphology 0.0128098817078067 0.0671540163291236 0.749629187056637 0.569444444444444 17.3 17 3 abnormal digit morphology 0.0128098817078067 0.0671540163291236 0.749629187056637 0.569444444444444 17.3 17 3 decreased anxiety-related response 0.00146738325512817 0.0114431464000546 0.749183244649107 0.569105691056911 17.3 17 3 abnormal suckling behavior 0.00680265288659582 0.0393983679986196 0.747967038083119 0.568181818181818 17.3 17 3 small kidney 0.00680265288659582 0.0393983679986196 0.747967038083119 0.568181818181818 17.3 17 3 abnormal gametogenesis 0.0474631701511572 0.175170082716622 0.747967038083119 0.568181818181818 17.3 17 3 increased exploration in new environment 0.00930182015147366 0.0513043849817976 0.747597671644559 0.567901234567901 17.3 17 3 abnormal hair follicle development 0.06703857573041 0.228592813062913 0.747158425068975 0.567567567567568 17.3 17 3 increased total body fat amount 0.00107892612253539 0.00902127304136734 0.74662739562685 0.567164179104478 17.3 17 3 abnormal lactation 0.0958783650496254 0.283587910892917 0.745972459314897 0.566666666666667 17.3 17 3 enhanced paired-pulse facilitation 0.0958783650496254 0.283587910892917 0.745972459314897 0.566666666666667 17.3 17 3 abnormal coat appearance 0.0174488534427137 0.0842796561917482 0.744064601362685 0.565217391304348 17.3 17 3 abnormal pulmonary artery morphology 0.139696828799581 0.373852460074187 0.744064601362685 0.565217391304348 17.3 17 3 abnormal cochlear ganglion morphology 0.139696828799581 0.373852460074187 0.744064601362685 0.565217391304348 17.3 17 3 increased vascular permeability 0.0663714278505708 0.227408990052748 0.742597018322522 0.564102564102564 17.3 17 3 atelectasis 0.0173303319702445 0.0841139874791212 0.741646189873965 0.563380281690141 17.3 17 3 respiratory failure 0.000782293511246864 0.00674507836820303 0.741032244352547 0.562913907284768 17.3 17 3 abnormal tooth morphology 0.0239017341017732 0.107417459039134 0.740487367702288 0.5625 17.3 17 3 abnormal lumbar vertebrae morphology 0.094656428839841 0.281479816783149 0.740487367702288 0.5625 17.3 17 3 vasculature congestion 0.209924019716391 0.458888490322 0.740487367702288 0.5625 17.3 17 3 poor circulation 0.209924019716391 0.458888490322 0.740487367702288 0.5625 17.3 17 3 abnormal epicardium morphology 0.209924019716391 0.458888490322 0.740487367702288 0.5625 17.3 17 3 increased pancreatic beta cell number 0.209924019716391 0.458888490322 0.740487367702288 0.5625 17.3 17 3 small pancreas 0.209924019716391 0.458888490322 0.740487367702288 0.5625 17.3 17 3 abnormal wound healing 0.209924019716391 0.458888490322 0.740487367702288 0.5625 17.3 17 3 decreased circulating growth hormone level 0.209924019716391 0.458888490322 0.740487367702288 0.5625 17.3 17 3 abnormal pulmonary alveolus wall morphology 0.209924019716391 0.458888490322 0.740487367702288 0.5625 17.3 17 3 decreased adipocyte glucose uptake 0.209924019716391 0.458888490322 0.740487367702288 0.5625 17.3 17 3 abnormal kidney physiology 0.0466411463501869 0.174522211191827 0.740487367702287 0.5625 17.3 17 3 abnormal excitatory postsynaptic potential 0.0124326898141191 0.0655913380967577 0.738480626868406 0.560975609756098 17.3 17 3 short humerus 0.0656191519999585 0.225434405441074 0.738480626868406 0.560975609756098 17.3 17 3 abnormal skin morphology 0.0236955157352141 0.106876872876419 0.73799414424201 0.560606060606061 17.3 17 3 abnormal vertebrae development 0.137288799651941 0.372433730723681 0.737196312734722 0.56 17.3 17 3 abnormal energy expenditure 0.137288799651941 0.372433730723681 0.737196312734722 0.56 17.3 17 3 short maxilla 0.0933119917238058 0.277647822264315 0.735647580985279 0.558823529411765 17.3 17 3 overexpanded pulmonary alveoli 0.0933119917238058 0.277647822264315 0.735647580985279 0.558823529411765 17.3 17 3 abnormal intestinal mucosa morphology 0.0647978682816187 0.222784654250901 0.734747155549557 0.558139534883721 17.3 17 3 impaired righting response 0.00887132789744855 0.0491479468706086 0.734424898025193 0.557894736842105 17.3 17 3 abnormal male meiosis 0.0324398854850578 0.135963294261299 0.733743402604817 0.557377049180328 17.3 17 3 abnormal action potential 0.0232330114685142 0.10555637630672 0.733435107057504 0.557142857142857 17.3 17 3 abnormal long bone epiphyseal plate proliferative zone 0.0450629321865614 0.168943547572074 0.731345548347938 0.555555555555556 17.3 17 3 abnormal uterus morphology 0.0918745809866789 0.275347012294414 0.731345548347938 0.555555555555556 17.3 17 3 short radius 0.0918745809866789 0.275347012294414 0.731345548347938 0.555555555555556 17.3 17 3 abnormal trigeminal nerve morphology 0.134728484010834 0.366670792097319 0.731345548347938 0.555555555555556 17.3 17 3 wrinkled skin 0.134728484010834 0.366670792097319 0.731345548347938 0.555555555555556 17.3 17 3 abnormal palate morphology 0.134728484010834 0.366670792097319 0.731345548347938 0.555555555555556 17.3 17 3 abnormal heart shape 0.204560496620091 0.458888490322 0.731345548347938 0.555555555555556 17.3 17 3 delayed kidney development 0.204560496620091 0.458888490322 0.731345548347938 0.555555555555556 17.3 17 3 right pulmonary isomerism 0.204560496620091 0.458888490322 0.731345548347938 0.555555555555556 17.3 17 3 abnormal phrenic nerve morphology 0.204560496620091 0.458888490322 0.731345548347938 0.555555555555556 17.3 17 3 acidosis 0.204560496620091 0.458888490322 0.731345548347938 0.555555555555556 17.3 17 3 absent ureter 0.204560496620091 0.458888490322 0.731345548347938 0.555555555555556 17.3 17 3 abnormal glycogen homeostasis 0.204560496620091 0.458888490322 0.731345548347938 0.555555555555556 17.3 17 3 abnormal pregnancy 0.204560496620091 0.458888490322 0.731345548347938 0.555555555555556 17.3 17 3 decreased fluid intake 0.204560496620091 0.458888490322 0.731345548347938 0.555555555555556 17.3 17 3 abnormal head movements 0.336012380765212 0.623789964912086 0.731345548347938 0.555555555555556 17.3 17 3 renal tubular acidosis 0.336012380765212 0.623789964912086 0.731345548347938 0.555555555555556 17.3 17 3 abnormal geniculate ganglion morphology 0.336012380765212 0.623789964912086 0.731345548347938 0.555555555555556 17.3 17 3 dilated uterus 0.336012380765212 0.623789964912086 0.731345548347938 0.555555555555556 17.3 17 3 wavy vibrissae 0.336012380765212 0.623789964912086 0.731345548347938 0.555555555555556 17.3 17 3 abnormal kindling response 0.336012380765212 0.623789964912086 0.731345548347938 0.555555555555556 17.3 17 3 abnormal lung volume 0.336012380765212 0.623789964912086 0.731345548347938 0.555555555555556 17.3 17 3 abnormal vomeronasal organ morphology 0.336012380765212 0.623789964912086 0.731345548347938 0.555555555555556 17.3 17 3 abnormal thymus lobule morphology 0.336012380765212 0.623789964912086 0.731345548347938 0.555555555555556 17.3 17 3 abnormal postural reflex 0.336012380765212 0.623789964912086 0.731345548347938 0.555555555555556 17.3 17 3 absent posterior semicircular canal 0.336012380765212 0.623789964912086 0.731345548347938 0.555555555555556 17.3 17 3 priapism 0.336012380765212 0.623789964912086 0.731345548347938 0.555555555555556 17.3 17 3 decreased muscle weight 0.336012380765212 0.623789964912086 0.731345548347938 0.555555555555556 17.3 17 3 small scapula 0.336012380765212 0.623789964912086 0.731345548347938 0.555555555555556 17.3 17 3 abnormal stria vascularis vasculature morphology 0.336012380765212 0.623789964912086 0.731345548347938 0.555555555555556 17.3 17 3 abnormal CNS synapse formation 0.336012380765212 0.623789964912086 0.731345548347938 0.555555555555556 17.3 17 3 abnormal gallbladder physiology 0.336012380765212 0.623789964912086 0.731345548347938 0.555555555555556 17.3 17 3 abnormal posterior eye segment morphology 0.336012380765212 0.623789964912086 0.731345548347938 0.555555555555556 17.3 17 3 decreased pulmonary ventilation 0.336012380765212 0.623789964912086 0.731345548347938 0.555555555555556 17.3 17 3 increased tidal volume 0.336012380765212 0.623789964912086 0.731345548347938 0.555555555555556 17.3 17 3 enhanced conditioned place preference behavior 0.336012380765212 0.623789964912086 0.731345548347938 0.555555555555556 17.3 17 3 multiflagellated sperm 0.336012380765212 0.623789964912086 0.731345548347938 0.555555555555556 17.3 17 3 abnormal cerebellar layer morphology 0.336012380765212 0.623789964912086 0.731345548347938 0.555555555555556 17.3 17 3 abnormal incisor color 0.336012380765212 0.623789964912086 0.731345548347938 0.555555555555556 17.3 17 3 retropulsion 0.336012380765212 0.623789964912086 0.731345548347938 0.555555555555556 17.3 17 3 decreased susceptibility to parasitic infection induced morbidity/mortality 0.336012380765212 0.623789964912086 0.731345548347938 0.555555555555556 17.3 17 3 abnormal oxidative phosphorylation 0.336012380765212 0.623789964912086 0.731345548347938 0.555555555555556 17.3 17 3 decreased bone trabecular spacing 0.336012380765212 0.623789964912086 0.731345548347938 0.555555555555556 17.3 17 3 decreased fatty acid oxidation 0.336012380765212 0.623789964912086 0.731345548347938 0.555555555555556 17.3 17 3 increased bone mineralization 0.336012380765212 0.623789964912086 0.731345548347938 0.555555555555556 17.3 17 3 enhanced leukocyte tethering or rolling 0.336012380765212 0.623789964912086 0.731345548347938 0.555555555555556 17.3 17 3 abnormal reproductive system physiology 0.0903676388351206 0.271321064094584 0.72749636125137 0.552631578947368 17.3 17 3 decreased threshold for auditory brainstem response 0.0903676388351206 0.271321064094584 0.72749636125137 0.552631578947368 17.3 17 3 short sternum 0.132069363444207 0.360024703087632 0.726301785945539 0.551724137931034 17.3 17 3 absent kidney 0.0620436488308403 0.214799688888956 0.725375380606322 0.551020408163265 17.3 17 3 abnormal epidermal layer morphology 0.0308549375094947 0.130975523984416 0.724986021840565 0.550724637681159 17.3 17 3 abnormal social investigation 0.0218729388484966 0.0999245828937287 0.724032092864459 0.55 17.3 17 3 abnormal skin pigmentation 0.0888099092961201 0.2669663436545 0.724032092864459 0.55 17.3 17 3 waved hair 0.199162112070211 0.457025603113145 0.724032092864459 0.55 17.3 17 3 increased urine glucose level 0.199162112070211 0.457025603113145 0.724032092864459 0.55 17.3 17 3 abnormal hair texture 0.199162112070211 0.457025603113145 0.724032092864459 0.55 17.3 17 3 abnormal fibula morphology 0.199162112070211 0.457025603113145 0.724032092864459 0.55 17.3 17 3 abnormal heart right ventricle morphology 0.199162112070211 0.457025603113145 0.724032092864459 0.55 17.3 17 3 abnormal incus morphology 0.199162112070211 0.457025603113145 0.724032092864459 0.55 17.3 17 3 abnormal circulating cytokine level 0.199162112070211 0.457025603113145 0.724032092864459 0.55 17.3 17 3 abnormal incisor morphology 0.043227976457676 0.16292362339162 0.724032092864459 0.55 17.3 17 3 increased kidney weight 0.0610605353101248 0.212757329836385 0.722741483073257 0.549019607843137 17.3 17 3 abnormal nervous system electrophysiology 0.0212781078262877 0.0974756781176626 0.720897754800111 0.547619047619048 17.3 17 3 abnormal optic nerve morphology 0.08721646939653 0.263930617547285 0.720897754800111 0.547619047619048 17.3 17 3 abnormal pancreatic islet morphology 0.0600571569418657 0.209820474568667 0.720306370259668 0.547169811320755 17.3 17 3 hypertension 0.0855995060381727 0.25919509588552 0.718048356559794 0.545454545454545 17.3 17 3 abnormal circadian rhythm 0.0855995060381727 0.25919509588552 0.718048356559794 0.545454545454545 17.3 17 3 embryonic lethality, incomplete penetrance 0.0855995060381727 0.25919509588552 0.718048356559794 0.545454545454545 17.3 17 3 dextrocardia 0.126601498925993 0.353050704684312 0.718048356559794 0.545454545454545 17.3 17 3 abnormal cochlear sensory epithelium morphology 0.193803283661768 0.446169058869641 0.718048356559794 0.545454545454545 17.3 17 3 abnormal retinal layer morphology 0.193803283661768 0.446169058869641 0.718048356559794 0.545454545454545 17.3 17 3 abnormal retinal outer plexiform layer morphology 0.193803283661768 0.446169058869641 0.718048356559794 0.545454545454545 17.3 17 3 abnormal circulating lipid level 0.193803283661768 0.446169058869641 0.718048356559794 0.545454545454545 17.3 17 3 rough coat 0.193803283661768 0.446169058869641 0.718048356559794 0.545454545454545 17.3 17 3 premature suture closure 0.320708531159141 0.623789964912086 0.718048356559794 0.545454545454545 17.3 17 3 abnormal awl hair morphology 0.320708531159141 0.623789964912086 0.718048356559794 0.545454545454545 17.3 17 3 abnormal glossopharyngeal ganglion morphology 0.320708531159141 0.623789964912086 0.718048356559794 0.545454545454545 17.3 17 3 social withdrawal 0.320708531159141 0.623789964912086 0.718048356559794 0.545454545454545 17.3 17 3 focal hepatic necrosis 0.320708531159141 0.623789964912086 0.718048356559794 0.545454545454545 17.3 17 3 retinal detachment 0.320708531159141 0.623789964912086 0.718048356559794 0.545454545454545 17.3 17 3 patent ductus arteriosus 0.320708531159141 0.623789964912086 0.718048356559794 0.545454545454545 17.3 17 3 rectal hemorrhage 0.320708531159141 0.623789964912086 0.718048356559794 0.545454545454545 17.3 17 3 abnormal nerve fiber response 0.320708531159141 0.623789964912086 0.718048356559794 0.545454545454545 17.3 17 3 pulmonary hypertension 0.320708531159141 0.623789964912086 0.718048356559794 0.545454545454545 17.3 17 3 abnormal lymph circulation 0.320708531159141 0.623789964912086 0.718048356559794 0.545454545454545 17.3 17 3 abnormal ureter development 0.320708531159141 0.623789964912086 0.718048356559794 0.545454545454545 17.3 17 3 pathological neovascularization 0.320708531159141 0.623789964912086 0.718048356559794 0.545454545454545 17.3 17 3 abnormal hair medulla 0.320708531159141 0.623789964912086 0.718048356559794 0.545454545454545 17.3 17 3 abnormal platelet aggregation 0.320708531159141 0.623789964912086 0.718048356559794 0.545454545454545 17.3 17 3 abnormal palatal shelf elevation 0.320708531159141 0.623789964912086 0.718048356559794 0.545454545454545 17.3 17 3 decreased palatine bone horizontal plate size 0.320708531159141 0.623789964912086 0.718048356559794 0.545454545454545 17.3 17 3 common atrioventricular valve 0.320708531159141 0.623789964912086 0.718048356559794 0.545454545454545 17.3 17 3 abnormal extraembryonic ectoderm morphology 0.320708531159141 0.623789964912086 0.718048356559794 0.545454545454545 17.3 17 3 abnormal dendritic cell chemotaxis 0.320708531159141 0.623789964912086 0.718048356559794 0.545454545454545 17.3 17 3 decreased food intake 0.0286467126827785 0.122122875404304 0.716533486609246 0.544303797468354 17.3 17 3 dehydration 0.0399059746831591 0.152365482769544 0.714629078671414 0.542857142857143 17.3 17 3 abnormal colon morphology 0.0569780860849398 0.202597819085232 0.71399158618375 0.542372881355932 17.3 17 3 abnormal urine homeostasis 0.0194235360849295 0.0924709014569612 0.71306190963924 0.541666666666667 17.3 17 3 abnormal digestive system morphology 0.188528894203826 0.435033046690184 0.71306190963924 0.541666666666667 17.3 17 3 increased stereotypic behavior 0.188528894203826 0.435033046690184 0.71306190963924 0.541666666666667 17.3 17 3 increased circulating total protein level 0.188528894203826 0.435033046690184 0.71306190963924 0.541666666666667 17.3 17 3 circling 0.0272788830297363 0.119675875725695 0.712416604743639 0.541176470588235 17.3 17 3 increased white adipose tissue amount 0.121093410699936 0.338259246621102 0.711579452446643 0.540540540540541 17.3 17 3 decreased cardiac muscle contractility 0.0181803422528477 0.0867183151562006 0.708842608398771 0.538461538461538 17.3 17 3 abnormal locomotor activation 0.0259132406190612 0.115414836239776 0.708842608398771 0.538461538461538 17.3 17 3 abnormal ureter morphology 0.183365937097195 0.430622625571187 0.708842608398771 0.538461538461538 17.3 17 3 no spontaneous movement 0.183365937097195 0.430622625571187 0.708842608398771 0.538461538461538 17.3 17 3 short hair 0.306940702976915 0.60983626090661 0.708842608398771 0.538461538461538 17.3 17 3 pup cannibalization 0.306940702976915 0.60983626090661 0.708842608398771 0.538461538461538 17.3 17 3 abnormal lung interstitium morphology 0.306940702976915 0.60983626090661 0.708842608398771 0.538461538461538 17.3 17 3 abnormal otolith morphology 0.306940702976915 0.60983626090661 0.708842608398771 0.538461538461538 17.3 17 3 absent lateral semicircular canal 0.306940702976915 0.60983626090661 0.708842608398771 0.538461538461538 17.3 17 3 abnormal insulin secretion 0.306940702976915 0.60983626090661 0.708842608398771 0.538461538461538 17.3 17 3 abnormal hair follicle inner root sheath morphology 0.306940702976915 0.60983626090661 0.708842608398771 0.538461538461538 17.3 17 3 abnormal excitatory postsynaptic currents 0.0371919571081171 0.145463825953524 0.708842608398771 0.538461538461538 17.3 17 3 abnormal lens fiber morphology 0.118363218317095 0.330818545577274 0.708842608398771 0.538461538461538 17.3 17 3 abnormal circulating hormone level 0.118363218317095 0.330818545577274 0.708842608398771 0.538461538461538 17.3 17 3 short ulna 0.115662365112729 0.323633445689441 0.706372773526301 0.536585365853659 17.3 17 3 hyperkeratosis 0.0518313109702292 0.189603508880067 0.705907442318445 0.536231884057971 17.3 17 3 abnormal jaw morphology 0.178330240360674 0.430622625571187 0.705226064478369 0.535714285714286 17.3 17 3 abnormal retinal inner nuclear layer morphology 0.178330240360674 0.430622625571187 0.705226064478369 0.535714285714286 17.3 17 3 enhanced coordination 0.178330240360674 0.430622625571187 0.705226064478369 0.535714285714286 17.3 17 3 deafness 0.0241267243691691 0.108330734419329 0.70475116477165 0.535353535353535 17.3 17 3 abnormal eye physiology 0.0726924970875265 0.239341610198838 0.702091726414021 0.533333333333333 17.3 17 3 delayed eyelid opening 0.173430504466585 0.430622625571187 0.702091726414021 0.533333333333333 17.3 17 3 abnormal pain threshold 0.173430504466585 0.430622625571187 0.702091726414021 0.533333333333333 17.3 17 3 decreased chondrocyte number 0.294393899632553 0.587017896060902 0.702091726414021 0.533333333333333 17.3 17 3 abnormal enteric neuron morphology 0.294393899632553 0.587017896060902 0.702091726414021 0.533333333333333 17.3 17 3 abnormal prostate gland morphology 0.294393899632553 0.587017896060902 0.702091726414021 0.533333333333333 17.3 17 3 abnormal seizure response to electrical stimulation 0.294393899632553 0.587017896060902 0.702091726414021 0.533333333333333 17.3 17 3 abnormal apical ectodermal ridge morphology 0.294393899632553 0.587017896060902 0.702091726414021 0.533333333333333 17.3 17 3 abnormal respiratory system morphology 0.294393899632553 0.587017896060902 0.702091726414021 0.533333333333333 17.3 17 3 abnormal bronchus morphology 0.294393899632553 0.587017896060902 0.702091726414021 0.533333333333333 17.3 17 3 increased anxiety-related response 0.0105918195811667 0.0574637976186526 0.700828971510398 0.532374100719424 17.3 17 3 abnormal innervation 0.107797456260973 0.314172434035349 0.700224461184196 0.531914893617021 17.3 17 3 increased systemic arterial blood pressure 0.107797456260973 0.314172434035349 0.700224461184196 0.531914893617021 17.3 17 3 abnormal bone remodeling 0.164052194528452 0.42353900766946 0.696929287249212 0.529411764705882 17.3 17 3 increased susceptibility to weight gain 0.164052194528452 0.42353900766946 0.696929287249212 0.529411764705882 17.3 17 3 distended urinary bladder 0.282849915217916 0.56581356180504 0.696929287249212 0.529411764705882 17.3 17 3 abnormal vagus nerve morphology 0.282849915217916 0.56581356180504 0.696929287249212 0.529411764705882 17.3 17 3 absence seizures 0.282849915217916 0.56581356180504 0.696929287249212 0.529411764705882 17.3 17 3 cochlear outer hair cell degeneration 0.0637798755273702 0.219973057077665 0.694778270930541 0.527777777777778 17.3 17 3 abnormal epidermis stratum granulosum morphology 0.159573726434707 0.412619173083508 0.694778270930541 0.527777777777778 17.3 17 3 abnormal reflex 0.159573726434707 0.412619173083508 0.694778270930541 0.527777777777778 17.3 17 3 impaired branching involved in ureteric bud morphogenesis 0.155233157216398 0.401813193106962 0.692853677382257 0.526315789473684 17.3 17 3 thin dermal layer 0.272149945720414 0.546321198714729 0.692853677382257 0.526315789473684 17.3 17 3 short vibrissae 0.272149945720414 0.546321198714729 0.692853677382257 0.526315789473684 17.3 17 3 delayed sexual maturation 0.272149945720414 0.546321198714729 0.692853677382257 0.526315789473684 17.3 17 3 increased circulating VLDL cholesterol level 0.272149945720414 0.546321198714729 0.692853677382257 0.526315789473684 17.3 17 3 eyelids fail to open 0.272149945720414 0.546321198714729 0.692853677382257 0.526315789473684 17.3 17 3 right-sided stomach 0.272149945720414 0.546321198714729 0.692853677382257 0.526315789473684 17.3 17 3 abnormal stapes morphology 0.262173965861546 0.528919497226761 0.689554374156627 0.523809523809524 17.3 17 3 abnormal bile salt homeostasis 0.262173965861546 0.528919497226761 0.689554374156627 0.523809523809524 17.3 17 3 increased liver weight 0.0533589647562373 0.193553249960988 0.688129675036469 0.522727272727273 17.3 17 3 abnormal amino acid level 0.143005582427803 0.377513447487399 0.688129675036469 0.522727272727273 17.3 17 3 abnormal femur morphology 0.0848309889980809 0.257337908698447 0.687683127551046 0.522388059701492 17.3 17 3 abnormal food intake 0.0828169707439966 0.251381592099685 0.686828862796325 0.521739130434783 17.3 17 3 abnormal inner ear morphology 0.139181516711147 0.372874553386083 0.686828862796324 0.521739130434783 17.3 17 3 abnormal carpal bone morphology 0.25282850714779 0.510686895274159 0.686828862796324 0.521739130434783 17.3 17 3 bidirectional circling 0.25282850714779 0.510686895274159 0.686828862796324 0.521739130434783 17.3 17 3 abnormal hepatocyte physiology 0.25282850714779 0.510686895274159 0.686828862796324 0.521739130434783 17.3 17 3 abnormal cardiovascular system morphology 0.135476513038719 0.368505004028228 0.685636451576192 0.520833333333333 17.3 17 3 increased circulating chloride level 0.131886442714383 0.359723164750031 0.68453943325367 0.52 17.3 17 3 abnormal feces composition 0.244038996635037 0.493734854924485 0.68453943325367 0.52 17.3 17 3 abnormal heart valve morphology 0.23574473272866 0.477148106316145 0.682589178458076 0.518518518518518 17.3 17 3 abnormal eye development 0.121765618742983 0.339946101709505 0.681718528995757 0.517857142857143 17.3 17 3 abnormal circulating glucose level 0.227895465628316 0.461448897639753 0.680907924323942 0.517241379310345 17.3 17 3 abnormal CNS synaptic transmission 0.0579263647836975 0.202701868441756 0.678156781195361 0.515151515151515 17.3 17 3 abnormal epidermis stratum basale morphology 0.213369445648918 0.458888490322 0.678156781195361 0.515151515151515 17.3 17 3 diarrhea 0.213369445648918 0.458888490322 0.678156781195361 0.515151515151515 17.3 17 3 abnormal middle ear ossicle morphology 0.213369445648918 0.458888490322 0.678156781195361 0.515151515151515 17.3 17 3 increased circulating corticosterone level 0.177119437530793 0.430622625571187 0.672837904480103 0.511111111111111 17.3 17 3 lethality at weaning, complete penetrance 0.177119437530793 0.430622625571187 0.672837904480103 0.511111111111111 17.3 17 3 pulmonary hypoplasia 0.17193010152872 0.430622625571187 0.672215482736828 0.51063829787234 17.3 17 3 abnormal cued conditioning behavior 0.16214766117487 0.419056942516873 0.671117091425167 0.509803921568627 17.3 17 3 abnormal neuron differentiation 0.060232521074207 0.210285468311705 0.669964761254451 0.508928571428571 17.3 17 3 syndactyly 0.144667191486104 0.377513447487399 0.669367112047266 0.508474576271186 17.3 17 3 obese 0.113217129805326 0.318230484066657 0.666759188234094 0.506493506493506 17.3 17 3 polyuria 0.113217129805326 0.318230484066657 0.666759188234094 0.506493506493506 17.3 17 3 abnormal crypts of Lieberkuhn morphology 0.272227186254033 0.546321198714729 0.658210993513144 0.5 17.3 17 3 abnormal diaphragm morphology 0.272227186254033 0.546321198714729 0.658210993513144 0.5 17.3 17 3 abnormal serotonin level 0.272227186254033 0.546321198714729 0.658210993513144 0.5 17.3 17 3 abnormal auditory brainstem response waveform shape 0.272227186254033 0.546321198714729 0.658210993513144 0.5 17.3 17 3 abnormal stomach morphology 0.304712056172879 0.607105518406117 0.658210993513144 0.5 17.3 17 3 small seminal vesicle 0.304712056172879 0.607105518406117 0.658210993513144 0.5 17.3 17 3 absent mandible 0.378863779548715 0.623789964912086 0.658210993513144 0.5 17.3 17 3 intestinal ulcer 0.330544648061325 0.623789964912086 0.658210993513144 0.5 17.3 17 3 increased body size 0.330544648061325 0.623789964912086 0.658210993513144 0.5 17.3 17 3 abnormal extraembryonic endoderm formation 0.378863779548715 0.623789964912086 0.658210993513144 0.5 17.3 17 3 increased coping response 0.330544648061325 0.623789964912086 0.658210993513144 0.5 17.3 17 3 paternal imprinting 0.378863779548715 0.623789964912086 0.658210993513144 0.5 17.3 17 3 decreased cardiac output 0.330544648061325 0.623789964912086 0.658210993513144 0.5 17.3 17 3 abnormal channel response 0.330544648061325 0.623789964912086 0.658210993513144 0.5 17.3 17 3 decreased aggression towards mice 0.378863779548715 0.623789964912086 0.658210993513144 0.5 17.3 17 3 small epididymis 0.378863779548715 0.623789964912086 0.658210993513144 0.5 17.3 17 3 decreased circulating estradiol level 0.330544648061325 0.623789964912086 0.658210993513144 0.5 17.3 17 3 abnormal intestinal lipid absorption 0.378863779548715 0.623789964912086 0.658210993513144 0.5 17.3 17 3 decreased creatinine clearance 0.378863779548715 0.623789964912086 0.658210993513144 0.5 17.3 17 3 impaired behavioral response to addictive substance 0.378863779548715 0.623789964912086 0.658210993513144 0.5 17.3 17 3 dilated respiratory conducting tubes 0.378863779548715 0.623789964912086 0.658210993513144 0.5 17.3 17 3 increased food intake 0.124281450255708 0.346775218744894 0.658210993513144 0.5 17.3 17 3 abnormal hair shaft morphology 0.20838369001872 0.458888490322 0.658210993513144 0.5 17.3 17 3 head tilt 0.253678228203805 0.512195286247537 0.658210993513144 0.5 17.3 17 3 thin skin 0.262686696769384 0.529524439395335 0.658210993513144 0.5 17.3 17 3 impaired synaptic plasticity 0.262686696769384 0.529524439395335 0.658210993513144 0.5 17.3 17 3 abnormal estrous cycle 0.282360426790047 0.565516555265896 0.658210993513144 0.5 17.3 17 3 emphysema 0.282360426790047 0.565516555265896 0.658210993513144 0.5 17.3 17 3 abnormal stria vascularis morphology 0.293159225096647 0.586200620922756 0.658210993513144 0.5 17.3 17 3 abnormal adipose tissue distribution 0.421462650562604 0.623789964912086 0.658210993513144 0.5 17.3 17 3 abnormal malleus morphology 0.317128120091753 0.623789964912086 0.658210993513144 0.5 17.3 17 3 abnormal esophagus morphology 0.421462650562604 0.623789964912086 0.658210993513144 0.5 17.3 17 3 abnormal foregut morphology 0.317128120091753 0.623789964912086 0.658210993513144 0.5 17.3 17 3 abnormal rectum morphology 0.421462650562604 0.623789964912086 0.658210993513144 0.5 17.3 17 3 abnormal kidney blood vessel morphology 0.398753845274567 0.623789964912086 0.658210993513144 0.5 17.3 17 3 absent spleen 0.361139333815742 0.623789964912086 0.658210993513144 0.5 17.3 17 3 abnormal retinal rod cell morphology 0.361139333815742 0.623789964912086 0.658210993513144 0.5 17.3 17 3 irregularly shaped pupil 0.398753845274567 0.623789964912086 0.658210993513144 0.5 17.3 17 3 absent optic nerve 0.421462650562604 0.623789964912086 0.658210993513144 0.5 17.3 17 3 impaired embryo implantation 0.421462650562604 0.623789964912086 0.658210993513144 0.5 17.3 17 3 abnormal fluid regulation 0.398753845274567 0.623789964912086 0.658210993513144 0.5 17.3 17 3 apnea 0.317128120091753 0.623789964912086 0.658210993513144 0.5 17.3 17 3 absent otoliths 0.398753845274567 0.623789964912086 0.658210993513144 0.5 17.3 17 3 abnormal aorta elastic fiber morphology 0.421462650562604 0.623789964912086 0.658210993513144 0.5 17.3 17 3 absent tail 0.421462650562604 0.623789964912086 0.658210993513144 0.5 17.3 17 3 decreased circulating ketone body level 0.421462650562604 0.623789964912086 0.658210993513144 0.5 17.3 17 3 increased fear-related response 0.421462650562604 0.623789964912086 0.658210993513144 0.5 17.3 17 3 decreased activity of thyroid 0.361139333815742 0.623789964912086 0.658210993513144 0.5 17.3 17 3 absent ovary 0.421462650562604 0.623789964912086 0.658210993513144 0.5 17.3 17 3 delayed somite formation 0.421462650562604 0.623789964912086 0.658210993513144 0.5 17.3 17 3 abnormal nucleotide metabolism 0.421462650562604 0.623789964912086 0.658210993513144 0.5 17.3 17 3 abnormal hair cuticle 0.398753845274567 0.623789964912086 0.658210993513144 0.5 17.3 17 3 decreased heart rate variability 0.361139333815742 0.623789964912086 0.658210993513144 0.5 17.3 17 3 abnormal postnatal subventricular zone morphology 0.345137779370616 0.623789964912086 0.658210993513144 0.5 17.3 17 3 abnormal iris pigmentation 0.398753845274567 0.623789964912086 0.658210993513144 0.5 17.3 17 3 increased circulating growth hormone level 0.398753845274567 0.623789964912086 0.658210993513144 0.5 17.3 17 3 abnormal anterior eye segment morphology 0.361139333815742 0.623789964912086 0.658210993513144 0.5 17.3 17 3 abnormal patella morphology 0.421462650562604 0.623789964912086 0.658210993513144 0.5 17.3 17 3 abnormal somatic nervous system physiology 0.421462650562604 0.623789964912086 0.658210993513144 0.5 17.3 17 3 decreased keratinocyte proliferation 0.421462650562604 0.623789964912086 0.658210993513144 0.5 17.3 17 3 impaired behavioral response to cocaine 0.421462650562604 0.623789964912086 0.658210993513144 0.5 17.3 17 3 decreased oligodendrocyte number 0.421462650562604 0.623789964912086 0.658210993513144 0.5 17.3 17 3 abnormal aorta elastic tissue morphology 0.421462650562604 0.623789964912086 0.658210993513144 0.5 17.3 17 3 abnormal heart electrocardiography waveform feature 0.345137779370616 0.623789964912086 0.658210993513144 0.5 17.3 17 3 atrioventricular block 0.361139333815742 0.623789964912086 0.658210993513144 0.5 17.3 17 3 increased type II pneumocyte number 0.421462650562604 0.623789964912086 0.658210993513144 0.5 17.3 17 3 increased lung compliance 0.398753845274567 0.623789964912086 0.658210993513144 0.5 17.3 17 3 abnormal respiratory motile cilium morphology 0.421462650562604 0.623789964912086 0.658210993513144 0.5 17.3 17 3 abnormal respiratory motile cilium physiology 0.398753845274567 0.623789964912086 0.658210993513144 0.5 17.3 17 3 abnormal renal tubule epithelial cell primary cilium morphology 0.398753845274567 0.623789964912086 0.658210993513144 0.5 17.3 17 3 absent maxillary shelf 0.448013838585731 0.642881121131817 0.658210993513144 0.5 17.3 17 3 abnormal epidermis suprabasal layer morphology 0.448013838585731 0.642881121131817 0.658210993513144 0.5 17.3 17 3 abnormal grooming behavior 0.448013838585731 0.642881121131817 0.658210993513144 0.5 17.3 17 3 absent trophoblast giant cells 0.448013838585731 0.642881121131817 0.658210993513144 0.5 17.3 17 3 abnormal respiratory mechanics 0.448013838585731 0.642881121131817 0.658210993513144 0.5 17.3 17 3 abnormal PNS synaptic transmission 0.448013838585731 0.642881121131817 0.658210993513144 0.5 17.3 17 3 increased natural killer cell mediated cytotoxicity 0.448013838585731 0.642881121131817 0.658210993513144 0.5 17.3 17 3 rickets 0.448013838585731 0.642881121131817 0.658210993513144 0.5 17.3 17 3 lymphedema 0.448013838585731 0.642881121131817 0.658210993513144 0.5 17.3 17 3 cochlear ganglion hypoplasia 0.448013838585731 0.642881121131817 0.658210993513144 0.5 17.3 17 3 abnormal ear physiology 0.448013838585731 0.642881121131817 0.658210993513144 0.5 17.3 17 3 abnormal placental transport 0.448013838585731 0.642881121131817 0.658210993513144 0.5 17.3 17 3 decreased thyroxine level 0.448013838585731 0.642881121131817 0.658210993513144 0.5 17.3 17 3 crystalluria 0.448013838585731 0.642881121131817 0.658210993513144 0.5 17.3 17 3 abnormal sperm principal piece morphology 0.448013838585731 0.642881121131817 0.658210993513144 0.5 17.3 17 3 sinus bradycardia 0.448013838585731 0.642881121131817 0.658210993513144 0.5 17.3 17 3 abnormal pulmonary interalveolar septum morphology 0.448013838585731 0.642881121131817 0.658210993513144 0.5 17.3 17 3 abnormal eye electrophysiology 0.0912388586166104 0.273771605318237 0.652771233236176 0.495867768595041 17.3 17 3 cardiomyopathy 0.265015137417876 0.534001745100824 0.643584082546186 0.488888888888889 17.3 17 3 abnormal intestinal goblet cell morphology 0.315632931805616 0.623789964912086 0.639404965127054 0.485714285714286 17.3 17 3 abnormal tail morphology 0.226538720046398 0.458888490322 0.638265205830928 0.484848484848485 17.3 17 3 single kidney 0.327622706823552 0.623789964912086 0.638265205830928 0.484848484848485 17.3 17 3 head tossing 0.327622706823552 0.623789964912086 0.638265205830928 0.484848484848485 17.3 17 3 abnormal body temperature homeostasis 0.340402392836006 0.623789964912086 0.636978380819172 0.483870967741935 17.3 17 3 abnormal retinal photoreceptor layer morphology 0.340402392836006 0.623789964912086 0.636978380819172 0.483870967741935 17.3 17 3 abnormal kidney development 0.248105985367995 0.501759055774706 0.636270627062706 0.483333333333333 17.3 17 3 polyphagia 0.272562575004766 0.546773713971254 0.633832808568213 0.481481481481481 17.3 17 3 cryptorchism 0.368753142228226 0.623789964912086 0.633832808568213 0.481481481481481 17.3 17 3 abnormal hair growth 0.281461953653894 0.564171321284498 0.632895186070331 0.480769230769231 17.3 17 3 decreased body temperature 0.281461953653894 0.564171321284498 0.632895186070331 0.480769230769231 17.3 17 3 diaphragmatic hernia 0.384595003282568 0.623789964912086 0.631882553772619 0.48 17.3 17 3 hypotension 0.401784443898732 0.623789964912086 0.629593124229964 0.478260869565217 17.3 17 3 decreased epididymis weight 0.401784443898732 0.623789964912086 0.629593124229964 0.478260869565217 17.3 17 3 abnormal muscle morphology 0.332959470171482 0.623789964912086 0.626867612869661 0.476190476190476 17.3 17 3 increased vasoconstriction 0.420559428015225 0.623789964912086 0.626867612869661 0.476190476190476 17.3 17 3 hypoalgesia 0.420559428015225 0.623789964912086 0.626867612869661 0.476190476190476 17.3 17 3 increased keratinocyte proliferation 0.420559428015225 0.623789964912086 0.626867612869661 0.476190476190476 17.3 17 3 decreased vocalization 0.420559428015225 0.623789964912086 0.626867612869661 0.476190476190476 17.3 17 3 flaky skin 0.441229783101537 0.636450614940606 0.623568309644032 0.473684210526316 17.3 17 3 shiny skin 0.441229783101537 0.636450614940606 0.623568309644032 0.473684210526316 17.3 17 3 abnormal neurotransmitter level 0.441229783101537 0.636450614940606 0.623568309644032 0.473684210526316 17.3 17 3 abnormal response to novelty 0.441229783101537 0.636450614940606 0.623568309644032 0.473684210526316 17.3 17 3 maternal imprinting 0.441229783101537 0.636450614940606 0.623568309644032 0.473684210526316 17.3 17 3 abnormal cochlear inner hair cell morphology 0.441229783101537 0.636450614940606 0.623568309644032 0.473684210526316 17.3 17 3 abnormal systemic arterial blood pressure 0.371066087659869 0.623789964912086 0.621643716095748 0.472222222222222 17.3 17 3 cochlear inner hair cell degeneration 0.335634169834077 0.623789964912086 0.619492699777077 0.470588235294118 17.3 17 3 abnormal heart rate 0.464209436731646 0.664205334408956 0.619492699777077 0.470588235294118 17.3 17 3 abnormal touch/ nociception 0.464209436731646 0.664205334408956 0.619492699777077 0.470588235294118 17.3 17 3 abnormal duodenum morphology 0.464209436731646 0.664205334408956 0.619492699777077 0.470588235294118 17.3 17 3 decreased growth hormone level 0.464209436731646 0.664205334408956 0.619492699777077 0.470588235294118 17.3 17 3 coloboma 0.464209436731646 0.664205334408956 0.619492699777077 0.470588235294118 17.3 17 3 increased circulating magnesium level 0.464209436731646 0.664205334408956 0.619492699777077 0.470588235294118 17.3 17 3 abnormal electroretinogram waveform feature 0.464209436731646 0.664205334408956 0.619492699777077 0.470588235294118 17.3 17 3 decreased urine osmolality 0.346891879104167 0.623789964912086 0.617912361257238 0.469387755102041 17.3 17 3 abnormal cartilage development 0.371106240896645 0.623789964912086 0.614330260612268 0.466666666666667 17.3 17 3 abnormal hair cycle 0.416819752684499 0.623789964912086 0.614330260612268 0.466666666666667 17.3 17 3 abnormal synaptic transmission 0.416819752684499 0.623789964912086 0.614330260612268 0.466666666666667 17.3 17 3 abnormal epidermis stratum spinosum morphology 0.49006879771133 0.691461221955152 0.614330260612268 0.466666666666667 17.3 17 3 no suckling reflex 0.49006879771133 0.691461221955152 0.614330260612268 0.466666666666667 17.3 17 3 dilated ureter 0.49006879771133 0.691461221955152 0.614330260612268 0.466666666666667 17.3 17 3 abnormal pericyte morphology 0.49006879771133 0.691461221955152 0.614330260612268 0.466666666666667 17.3 17 3 lactation failure 0.49006879771133 0.691461221955152 0.614330260612268 0.466666666666667 17.3 17 3 ostium primum atrial septal defect 0.49006879771133 0.691461221955152 0.614330260612268 0.466666666666667 17.3 17 3 abnormal axon guidance 0.384156353386102 0.623789964912086 0.612289296291297 0.465116279069767 17.3 17 3 abnormal cochlea morphology 0.369997588499047 0.623789964912086 0.609454623623282 0.462962962962963 17.3 17 3 abnormal kidney cortex morphology 0.453066100805158 0.649756082878542 0.607579378627518 0.461538461538462 17.3 17 3 tight skin 0.519624319921767 0.722454807111484 0.607579378627518 0.461538461538462 17.3 17 3 abnormal dopaminergic neuron morphology 0.519624319921767 0.722454807111484 0.607579378627518 0.461538461538462 17.3 17 3 abnormal GABAergic neuron morphology 0.519624319921767 0.722454807111484 0.607579378627518 0.461538461538462 17.3 17 3 abnormal afterhyperpolarization 0.519624319921767 0.722454807111484 0.607579378627518 0.461538461538462 17.3 17 3 decreased alcohol consumption 0.519624319921767 0.722454807111484 0.607579378627518 0.461538461538462 17.3 17 3 muscle fatigue 0.519624319921767 0.722454807111484 0.607579378627518 0.461538461538462 17.3 17 3 vestibular hair cell degeneration 0.519624319921767 0.722454807111484 0.607579378627518 0.461538461538462 17.3 17 3 increased renin activity 0.519624319921767 0.722454807111484 0.607579378627518 0.461538461538462 17.3 17 3 abnormal gut flora balance 0.519624319921767 0.722454807111484 0.607579378627518 0.461538461538462 17.3 17 3 increased insulin secretion 0.427775148305384 0.623789964912086 0.604842534579646 0.459459459459459 17.3 17 3 abnormal heart left ventricle morphology 0.366135217037269 0.623789964912086 0.603360077387049 0.458333333333333 17.3 17 3 curly vibrissae 0.473416717889253 0.676795451580182 0.603360077387049 0.458333333333333 17.3 17 3 decreased ovulation rate 0.473416717889253 0.676795451580182 0.603360077387049 0.458333333333333 17.3 17 3 impaired behavioral response to xenobiotic 0.444047329149575 0.640329119570763 0.601792908354875 0.457142857142857 17.3 17 3 abnormal inhibitory postsynaptic currents 0.387711192318033 0.623789964912086 0.600133552909043 0.455882352941176 17.3 17 3 absent vibrissae 0.461335553591734 0.661424893117832 0.598373630466495 0.454545454545455 17.3 17 3 decreased airway responsiveness 0.495571744643476 0.699027340402975 0.598373630466495 0.454545454545455 17.3 17 3 decreased atrioventricular cushion size 0.554101594774554 0.764887745283964 0.598373630466495 0.454545454545455 17.3 17 3 increased mast cell number 0.554101594774554 0.764887745283964 0.598373630466495 0.454545454545455 17.3 17 3 secondary sex reversal 0.554101594774554 0.764887745283964 0.598373630466495 0.454545454545455 17.3 17 3 abnormal primary sex determination 0.554101594774554 0.764887745283964 0.598373630466495 0.454545454545455 17.3 17 3 abnormal vestibular ganglion morphology 0.554101594774554 0.764887745283964 0.598373630466495 0.454545454545455 17.3 17 3 enlarged placenta 0.554101594774554 0.764887745283964 0.598373630466495 0.454545454545455 17.3 17 3 abnormal crista ampullaris neuroepithelium morphology 0.554101594774554 0.764887745283964 0.598373630466495 0.454545454545455 17.3 17 3 increased motor neuron number 0.554101594774554 0.764887745283964 0.598373630466495 0.454545454545455 17.3 17 3 increased circulating triiodothyronine level 0.554101594774554 0.764887745283964 0.598373630466495 0.454545454545455 17.3 17 3 enhanced behavioral response to addictive substance 0.554101594774554 0.764887745283964 0.598373630466495 0.454545454545455 17.3 17 3 increased subcutaneous adipose tissue amount 0.554101594774554 0.764887745283964 0.598373630466495 0.454545454545455 17.3 17 3 abnormal brain ependyma motile cilium morphology 0.554101594774554 0.764887745283964 0.598373630466495 0.454545454545455 17.3 17 3 abnormal phrenic nerve innervation pattern to diaphragm 0.554101594774554 0.764887745283964 0.598373630466495 0.454545454545455 17.3 17 3 abnormal vibrissa morphology 0.451560098988504 0.647783013975723 0.595524232226178 0.452380952380952 17.3 17 3 decreased neuronal precursor cell number 0.479751696089141 0.678811548844546 0.594513155431227 0.451612903225806 17.3 17 3 head bobbing 0.467628155579914 0.668904564120205 0.59238989416183 0.45 17.3 17 3 abnormal dopamine level 0.519850513426836 0.722454807111484 0.59238989416183 0.45 17.3 17 3 abnormal trachea morphology 0.519850513426836 0.722454807111484 0.59238989416183 0.45 17.3 17 3 enhanced behavioral response to xenobiotic 0.519850513426836 0.722454807111484 0.59238989416183 0.45 17.3 17 3 decreased retinal photoreceptor cell number 0.499426960461671 0.704066060724516 0.59012020108075 0.448275862068966 17.3 17 3 stomach inflammation 0.499426960461671 0.704066060724516 0.59012020108075 0.448275862068966 17.3 17 3 increased susceptibility to pharmacologically induced seizures 0.412021341149896 0.623789964912086 0.589647348355525 0.447916666666667 17.3 17 3 abnormal retinal outer nuclear layer morphology 0.484560391925937 0.684854531202141 0.588925625774919 0.447368421052632 17.3 17 3 abnormal retinal photoreceptor morphology 0.521329197493513 0.722454807111484 0.58077440604101 0.441176470588235 17.3 17 3 increased dopamine level 0.541347581030421 0.749987250244039 0.575934619324001 0.4375 17.3 17 3 delayed hair appearance 0.576561589615585 0.775894757874881 0.575934619324001 0.4375 17.3 17 3 abnormal intestinal absorption 0.576561589615585 0.775894757874881 0.575934619324001 0.4375 17.3 17 3 abnormal epididymis epithelium morphology 0.576561589615585 0.775894757874881 0.575934619324001 0.4375 17.3 17 3 decreased circulating prolactin level 0.576561589615585 0.775894757874881 0.575934619324001 0.4375 17.3 17 3 decreased circulating triiodothyronine level 0.576561589615585 0.775894757874881 0.575934619324001 0.4375 17.3 17 3 decreased skeletal muscle weight 0.576561589615585 0.775894757874881 0.575934619324001 0.4375 17.3 17 3 decreased midbrain size 0.576561589615585 0.775894757874881 0.575934619324001 0.4375 17.3 17 3 abnormal crista ampullaris morphology 0.567715822139433 0.775894757874881 0.572357385663604 0.434782608695652 17.3 17 3 increased circulating luteinizing hormone level 0.585202915610036 0.78431694643317 0.564180851582695 0.428571428571429 17.3 17 3 abnormal vasoconstriction 0.610277175907166 0.810498918883649 0.564180851582695 0.428571428571429 17.3 17 3 abnormal pinna reflex 0.610277175907166 0.810498918883649 0.564180851582695 0.428571428571429 17.3 17 3 abnormal placing response 0.610277175907166 0.810498918883649 0.564180851582695 0.428571428571429 17.3 17 3 extended life span 0.610277175907166 0.810498918883649 0.564180851582695 0.428571428571429 17.3 17 3 abnormal uterus development 0.610277175907166 0.810498918883649 0.564180851582695 0.428571428571429 17.3 17 3 enlarged stomach 0.610277175907166 0.810498918883649 0.564180851582695 0.428571428571429 17.3 17 3 abnormal squamosal bone morphology 0.610277175907166 0.810498918883649 0.564180851582695 0.428571428571429 17.3 17 3 abnormal associative learning 0.594318827485544 0.792721123159107 0.564180851582695 0.428571428571429 17.3 17 3 increased susceptibility to weight loss 0.594019189456962 0.792721123159107 0.559479344486173 0.425 17.3 17 3 dilated heart atrium 0.600303811774716 0.798959728084326 0.558482055102062 0.424242424242424 17.3 17 3 abnormal tectorial membrane morphology 0.609307219834314 0.810498918883649 0.556947763741891 0.423076923076923 17.3 17 3 abnormal nail morphology 0.623346054310067 0.826972432051356 0.554282941905806 0.421052631578947 17.3 17 3 decreased grooming behavior 0.623346054310067 0.826972432051356 0.554282941905806 0.421052631578947 17.3 17 3 abnormal behavioral response to xenobiotic 0.623346054310067 0.826972432051356 0.554282941905806 0.421052631578947 17.3 17 3 abnormal digestive system physiology 0.619285380515112 0.82224306593613 0.552897234551041 0.42 17.3 17 3 abnormal glossopharyngeal nerve morphology 0.64884369778309 0.836010718672092 0.548509161260954 0.416666666666667 17.3 17 3 ear inflammation 0.64884369778309 0.836010718672092 0.548509161260954 0.416666666666667 17.3 17 3 increased litter size 0.64884369778309 0.836010718672092 0.548509161260954 0.416666666666667 17.3 17 3 increased placenta weight 0.64884369778309 0.836010718672092 0.548509161260954 0.416666666666667 17.3 17 3 increased retinal apoptosis 0.645750648655939 0.836010718672092 0.544726339459154 0.413793103448276 17.3 17 3 enlarged sebaceous gland 0.655208096634342 0.836010718672092 0.542056112304942 0.411764705882353 17.3 17 3 increased aggression towards mice 0.655208096634342 0.836010718672092 0.542056112304942 0.411764705882353 17.3 17 3 common atrium 0.655208096634342 0.836010718672092 0.542056112304942 0.411764705882353 17.3 17 3 abnormal single cell response 0.670350861949547 0.836010718672092 0.536320068788488 0.407407407407407 17.3 17 3 abnormal long term potentiation 0.677907488929933 0.836870907549979 0.53479643222943 0.40625 17.3 17 3 increased percent body fat/body weight 0.705661944820315 0.86640379454123 0.531631956299078 0.403846153846154 17.3 17 3 interdigital webbing 0.69041609470439 0.851256523210493 0.526568794810516 0.4 17.3 17 3 decreased salivation 0.69041609470439 0.851256523210493 0.526568794810516 0.4 17.3 17 3 increased alcohol consumption 0.69041609470439 0.851256523210493 0.526568794810516 0.4 17.3 17 3 decreased aggression towards males 0.69041609470439 0.851256523210493 0.526568794810516 0.4 17.3 17 3 abnormal Muller cell morphology 0.69041609470439 0.851256523210493 0.526568794810516 0.4 17.3 17 3 abnormal hearing physiology 0.692343081565555 0.852412652696129 0.526568794810516 0.4 17.3 17 3 decreased paired-pulse facilitation 0.692343081565555 0.852412652696129 0.526568794810516 0.4 17.3 17 3 decreased skin tensile strength 0.692343081565555 0.852412652696129 0.526568794810516 0.4 17.3 17 3 abnormal inner ear vestibule morphology 0.69631707000055 0.855141304184827 0.526568794810516 0.4 17.3 17 3 abnormal stomach mucosa morphology 0.69631707000055 0.855141304184827 0.526568794810516 0.4 17.3 17 3 abnormal innervation pattern to muscle 0.723732002066879 0.879474037685081 0.515121647097243 0.391304347826087 17.3 17 3 abnormal metanephric mesenchyme morphology 0.724280645997052 0.879925815344404 0.511941883843557 0.388888888888889 17.3 17 3 abnormal cranial ganglia morphology 0.750927097306291 0.905883198132589 0.509582704655338 0.387096774193548 17.3 17 3 abnormal photoreceptor outer segment morphology 0.775232072288555 0.933392923435519 0.508617585896521 0.386363636363636 17.3 17 3 absent trabeculae carneae 0.729605808946417 0.884882715628577 0.506316148856265 0.384615384615385 17.3 17 3 dystrophic cardiac calcinosis 0.729605808946417 0.884882715628577 0.506316148856265 0.384615384615385 17.3 17 3 increased synaptic depression 0.729605808946417 0.884882715628577 0.506316148856265 0.384615384615385 17.3 17 3 anal atresia 0.729605808946417 0.884882715628577 0.506316148856265 0.384615384615385 17.3 17 3 decreased endocochlear potential 0.729605808946417 0.884882715628577 0.506316148856265 0.384615384615385 17.3 17 3 hyperalgesia 0.729605808946417 0.884882715628577 0.506316148856265 0.384615384615385 17.3 17 3 decreased cardiac stroke volume 0.729605808946417 0.884882715628577 0.506316148856265 0.384615384615385 17.3 17 3 decreased pancreatic beta cell number 0.773394159319892 0.931596825480489 0.503337818568875 0.382352941176471 17.3 17 3 decreased cochlear coiling 0.758728797757673 0.914629456952853 0.493658245134858 0.375 17.3 17 3 abnormal pancreatic alpha cell morphology 0.758728797757673 0.914629456952853 0.493658245134858 0.375 17.3 17 3 abnormal fertilization 0.758728797757673 0.914629456952853 0.493658245134858 0.375 17.3 17 3 abnormal ear morphology 0.78315915781446 0.942709124153627 0.48499757416758 0.368421052631579 17.3 17 3 abnormal tracheal cartilage morphology 0.8040848462786 0.9459586488509 0.478698904373196 0.363636363636364 17.3 17 3 abnormal zigzag hair morphology 0.795899493968223 0.9459586488509 0.470150709652246 0.357142857142857 17.3 17 3 abnormal olfactory system physiology 0.795899493968223 0.9459586488509 0.470150709652246 0.357142857142857 17.3 17 3 abnormal kidney medulla morphology 0.795899493968223 0.9459586488509 0.470150709652246 0.357142857142857 17.3 17 3 abnormal imprinting 0.795899493968223 0.9459586488509 0.470150709652246 0.357142857142857 17.3 17 3 decreased cornea thickness 0.795899493968223 0.9459586488509 0.470150709652246 0.357142857142857 17.3 17 3 decreased tongue size 0.795899493968223 0.9459586488509 0.470150709652246 0.357142857142857 17.3 17 3 decreased circulating progesterone level 0.838247376304967 0.96690950547582 0.470150709652246 0.357142857142857 17.3 17 3 hydroureter 0.815194634734035 0.9459586488509 0.464619524832808 0.352941176470588 17.3 17 3 abnormal urinary bladder morphology 0.815194634734035 0.9459586488509 0.464619524832808 0.352941176470588 17.3 17 3 nephrocalcinosis 0.815194634734035 0.9459586488509 0.464619524832808 0.352941176470588 17.3 17 3 aminoaciduria 0.815194634734035 0.9459586488509 0.464619524832808 0.352941176470588 17.3 17 3 nuclear cataracts 0.832060121948486 0.960886515017112 0.460747695459201 0.35 17.3 17 3 blistering 0.846939696524851 0.976709548032252 0.457885908530883 0.347826086956522 17.3 17 3 altered righting response 0.848641193600139 0.977991646551006 0.438807329008763 0.333333333333333 17.3 17 3 greasy coat 0.848641193600139 0.977991646551006 0.438807329008763 0.333333333333333 17.3 17 3 abnormal neurotransmitter secretion 0.848641193600139 0.977991646551006 0.438807329008763 0.333333333333333 17.3 17 3 abnormal stomach glandular epithelium morphology 0.860651629102526 0.991603023340683 0.438807329008763 0.333333333333333 17.3 17 3 impaired conditioned place preference behavior 0.910027660566963 1 0.421255035848412 0.32 17.3 17 3 decreased chemically-elicited antinociception 0.896417385081633 1 0.415712206429354 0.315789473684211 17.3 17 3 abnormal photoreceptor inner segment morphology 0.896417385081633 1 0.415712206429354 0.315789473684211 17.3 17 3 abnormal pituitary gland morphology 0.889510464437624 1 0.411381870945715 0.3125 17.3 17 3 increased circulating estradiol level 0.889510464437624 1 0.411381870945715 0.3125 17.3 17 3 abnormal ocular fundus morphology 0.932189731348315 1 0.405052919085012 0.307692307692308 17.3 17 3 abnormal retinal cone cell morphology 0.92801200920549 1 0.400650169964523 0.304347826086957 17.3 17 3 increased susceptibility to age related obesity 0.92801200920549 1 0.400650169964523 0.304347826086957 17.3 17 3 increased urine calcium level 0.923999069281554 1 0.394926596107887 0.3 17.3 17 3 enlarged pancreas 0.000541162474938995 0.00951336859654241 4.38157166574433 0.833333333333333 17.1 17 1 abnormal leukocyte tethering or rolling 0.000541162474938995 0.00951336859654241 4.38157166574433 0.833333333333333 17.1 17 1 abnormal lymph node B cell domain morphology 7.74735008339811e-08 5.27987214587748e-06 4.20630879911455 0.8 17.1 17 1 decreased level of surface class I molecules 7.06973108895776e-05 0.00190419266045697 4.08946688802804 0.777777777777778 17.1 17 1 hypospadia 0.00034672699848517 0.00666010354233097 3.94341449916989 0.75 17.1 17 1 abnormal cellular cholesterol metabolism 0.00034672699848517 0.00666010354233097 3.94341449916989 0.75 17.1 17 1 abnormal macrophage activation involved in immune response 0.00034672699848517 0.00666010354233097 3.94341449916989 0.75 17.1 17 1 abnormal maternal decidual layer morphology 5.7745783718071e-06 0.000222701762788684 3.75563285635228 0.714285714285714 17.1 17 1 decreased activated T cell number 0.00164313895627119 0.0233560465927119 3.75563285635228 0.714285714285714 17.1 17 1 abnormal tumor incidence 0.00164313895627119 0.0233560465927119 3.75563285635228 0.714285714285714 17.1 17 1 abnormal gastrulation movements 0.00164313895627119 0.0233560465927119 3.75563285635228 0.714285714285714 17.1 17 1 abnormal MHC II cell surface expression on macrophages 0.00164313895627119 0.0233560465927119 3.75563285635228 0.714285714285714 17.1 17 1 atherosclerotic lesions 0.00164313895627119 0.0233560465927119 3.75563285635228 0.714285714285714 17.1 17 1 heart hemorrhage 0.00164313895627119 0.0233560465927119 3.75563285635228 0.714285714285714 17.1 17 1 arteritis 0.00164313895627119 0.0233560465927119 3.75563285635228 0.714285714285714 17.1 17 1 decreased brain cholesterol level 0.00164313895627119 0.0233560465927119 3.75563285635228 0.714285714285714 17.1 17 1 embryo tumor 0.00164313895627119 0.0233560465927119 3.75563285635228 0.714285714285714 17.1 17 1 abnormal immune cell physiology 0.00020291321167066 0.00433258896163747 3.68052019922523 0.7 17.1 17 1 decreased macrophage cytokine production 0.00020291321167066 0.00433258896163747 3.68052019922523 0.7 17.1 17 1 decreased mast cell number 3.41557249913586e-06 0.000142793892295806 3.61479662423907 0.6875 17.1 17 1 decreased red blood cell distribution width 0.000113870467891065 0.00275002707649537 3.50525733259546 0.666666666666667 17.1 17 1 multifocal hepatic necrosis 0.000898786373676353 0.0147573010199335 3.50525733259546 0.666666666666667 17.1 17 1 abnormal circulating chemokine level 8.27096963424594e-06 0.0003025593671351 3.4021615286956 0.647058823529412 17.1 17 1 multiple persisting craniopharyngeal ducts 6.24846256038019e-05 0.0017131223499639 3.38006957071705 0.642857142857143 17.1 17 1 abnormal dorsal-ventral polarity of the somites 0.000480685899370491 0.0087277822969642 3.34592745384112 0.636363636363636 17.1 17 1 abnormal cellular extravasation 3.40482416427166e-07 1.9696511880525e-05 3.28617874930825 0.625 17.1 17 1 failure of vascular branching 0.00380382555258122 0.0450572193430751 3.28617874930825 0.625 17.1 17 1 altered response to CNS ischemic injury 0.00380382555258122 0.0450572193430751 3.28617874930825 0.625 17.1 17 1 binucleate 0.00380382555258122 0.0450572193430751 3.28617874930825 0.625 17.1 17 1 accumulation of giant lysosomes in kidney/renal tubule cells 0.00380382555258122 0.0450572193430751 3.28617874930825 0.625 17.1 17 1 abnormal somite size 0.00380382555258122 0.0450572193430751 3.28617874930825 0.625 17.1 17 1 impaired macrophage chemotaxis 1.54635954212748e-10 1.78910202839167e-08 3.23562215316504 0.615384615384615 17.1 17 1 abnormal Peyer's patch follicle morphology 1.81812380015318e-05 0.000599017609653118 3.21315255487917 0.611111111111111 17.1 17 1 decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 7.24800778533892e-07 3.60588387320611e-05 3.15473159933592 0.6 17.1 17 1 increased mammary adenocarcinoma incidence 9.71696116395604e-06 0.000345299155647723 3.15473159933592 0.6 17.1 17 1 joint inflammation 0.000133973401452403 0.00310008219639863 3.15473159933592 0.6 17.1 17 1 abnormal dendritic cell morphology 0.000133973401452403 0.00310008219639863 3.15473159933592 0.6 17.1 17 1 peritoneal inflammation 0.00194259611668489 0.0261908284024589 3.15473159933592 0.6 17.1 17 1 abnormal gas homeostasis 0.00194259611668489 0.0261908284024589 3.15473159933592 0.6 17.1 17 1 abnormal gonadal fat pad morphology 0.00194259611668489 0.0261908284024589 3.15473159933592 0.6 17.1 17 1 absent inguinal lymph nodes 0.00194259611668489 0.0261908284024589 3.15473159933592 0.6 17.1 17 1 decreased transitional stage T2 B cell number 0.00194259611668489 0.0261908284024589 3.15473159933592 0.6 17.1 17 1 abnormal leukocyte adhesion 1.24140133322399e-09 1.2109748299587e-07 3.10080456344983 0.58974358974359 17.1 17 1 abnormal lymphocyte physiology 5.2440854238515e-11 7.24703471768366e-09 3.08615047761122 0.58695652173913 17.1 17 1 myocarditis 0.000994227503441687 0.0158028173470364 3.06710016602103 0.583333333333333 17.1 17 1 interstitial pneumonia 0.000994227503441687 0.0158028173470364 3.06710016602103 0.583333333333333 17.1 17 1 small intestinal inflammation 0.000994227503441687 0.0158028173470364 3.06710016602103 0.583333333333333 17.1 17 1 abnormal vascular endothelial cell development 0.000994227503441687 0.0158028173470364 3.06710016602103 0.583333333333333 17.1 17 1 impaired macrophage phagocytosis 3.61180054207912e-10 3.82312929720077e-08 3.05691046447279 0.581395348837209 17.1 17 1 abnormal spleen periarteriolar lymphoid sheath morphology 0.000510329515503318 0.00913269546629139 3.00450628508182 0.571428571428571 17.1 17 1 increased hemangioma incidence 0.000510329515503318 0.00913269546629139 3.00450628508182 0.571428571428571 17.1 17 1 vascular smooth muscle hypoplasia 0.000510329515503318 0.00913269546629139 3.00450628508182 0.571428571428571 17.1 17 1 lysosomal protein accumulation 0.000510329515503318 0.00913269546629139 3.00450628508182 0.571428571428571 17.1 17 1 decreased B cell proliferation 1.02228794630312e-16 3.91221733296772e-14 2.99499835379992 0.569620253164557 17.1 17 1 abnormal immune system morphology 3.78773222969262e-10 3.92582663390017e-08 2.97184860807007 0.565217391304348 17.1 17 1 abnormal level of surface class II molecules 0.00026271391568741 0.00533470094099945 2.95756087437742 0.5625 17.1 17 1 abnormal leukocyte migration 5.75160123002903e-11 7.53005687352486e-09 2.93228257630582 0.557692307692308 17.1 17 1 crypts of Lieberkuhn abscesses 0.00743512452621231 0.0722594637226333 2.92104777716289 0.555555555555556 17.1 17 1 abnormal thymus physiology 0.00743512452621231 0.0722594637226333 2.92104777716289 0.555555555555556 17.1 17 1 abnormal inguinal fat pad morphology 0.00743512452621231 0.0722594637226333 2.92104777716289 0.555555555555556 17.1 17 1 decreased susceptibility to atherosclerosis 0.00743512452621231 0.0722594637226333 2.92104777716289 0.555555555555556 17.1 17 1 absent cervical lymph nodes 0.00743512452621231 0.0722594637226333 2.92104777716289 0.555555555555556 17.1 17 1 decreased transitional stage T1 B cell number 0.00743512452621231 0.0722594637226333 2.92104777716289 0.555555555555556 17.1 17 1 abnormal incisor color 0.00743512452621231 0.0722594637226333 2.92104777716289 0.555555555555556 17.1 17 1 decreased effector memory CD4-positive, alpha-beta T cell number 0.00743512452621231 0.0722594637226333 2.92104777716289 0.555555555555556 17.1 17 1 increased cardiac muscle glycogen level 0.00743512452621231 0.0722594637226333 2.92104777716289 0.555555555555556 17.1 17 1 abnormal T cell subpopulation ratio 4.05313364645843e-07 2.21586152649788e-05 2.86793781757811 0.545454545454545 17.1 17 1 abnormal radial glial cell morphology 0.00369688837746218 0.0443181197057213 2.86793781757811 0.545454545454545 17.1 17 1 decreased metastatic potential 1.89074179756968e-05 0.000618844765980864 2.84802158273381 0.541666666666667 17.1 17 1 abnormal exocrine pancreas morphology 0.00185733841596946 0.0255255762968179 2.83116938401941 0.538461538461538 17.1 17 1 increased prostaglandin level 0.00185733841596946 0.0255255762968179 2.83116938401941 0.538461538461538 17.1 17 1 delayed intramembranous bone ossification 0.00094045078870436 0.0152402041491993 2.80420586607637 0.533333333333333 17.1 17 1 abnormal placenta size 0.00094045078870436 0.0152402041491993 2.80420586607637 0.533333333333333 17.1 17 1 decreased trabecular bone mass 0.00094045078870436 0.0152402041491993 2.80420586607637 0.533333333333333 17.1 17 1 abnormal dendritic cell physiology 6.64940147451059e-19 4.72582461938431e-16 2.80092992464404 0.532710280373832 17.1 17 1 increased fibroblast apoptosis 1.39956492743243e-06 6.63127191807271e-05 2.79325193691201 0.53125 17.1 17 1 decreased susceptibility to induced arthritis 1.86194597090844e-10 2.0584847122821e-08 2.7673084204701 0.526315789473684 17.1 17 1 decreased tumor incidence 0.000245263803922086 0.00506301835897253 2.7673084204701 0.526315789473684 17.1 17 1 increased acute inflammation 0.000126060123294369 0.00297227067957101 2.75413076132501 0.523809523809524 17.1 17 1 myeloid hyperplasia 2.45595721289318e-06 0.000108127319771182 2.70860793882377 0.515151515151515 17.1 17 1 decreased B-1 B cell number 3.50589079362488e-07 2.00480536761882e-05 2.6963517943042 0.512820512820513 17.1 17 1 impaired hematopoiesis 7.32651909275602e-09 5.97531680105922e-07 2.68049090139653 0.509803921568627 17.1 17 1 spleen hyperplasia 3.38127172670327e-12 6.7287307361395e-10 2.66399557277255 0.506666666666667 17.1 17 1 abnormal embryonic hematopoiesis 8.02366249243442e-06 0.000297755247893666 2.6289429994466 0.5 17.1 17 1 abnormal nursing 0.000111109211612929 0.00269643086719182 2.6289429994466 0.5 17.1 17 1 abnormal megakaryocyte differentiation 0.000822587691946999 0.0135959261376622 2.6289429994466 0.5 17.1 17 1 increased heart left ventricle size 0.00161818766172132 0.0233560465927119 2.6289429994466 0.5 17.1 17 1 altered tumor susceptibility 0.00639954925148267 0.0659166822487087 2.6289429994466 0.5 17.1 17 1 pale placenta 0.00639954925148267 0.0659166822487087 2.6289429994466 0.5 17.1 17 1 abnormal fatty acid level 0.00639954925148267 0.0659166822487087 2.6289429994466 0.5 17.1 17 1 reduced cerebellar foliation 0.00639954925148267 0.0659166822487087 2.6289429994466 0.5 17.1 17 1 abnormal leukocyte cell number 5.73968415800474e-05 0.00160420947674571 2.6289429994466 0.5 17.1 17 1 heart inflammation 5.73968415800474e-05 0.00160420947674571 2.6289429994466 0.5 17.1 17 1 pulmonary edema 5.73968415800474e-05 0.00160420947674571 2.6289429994466 0.5 17.1 17 1 increased mammary gland tumor incidence 0.000215730793590222 0.00454771482250573 2.6289429994466 0.5 17.1 17 1 decreased myocardial infarction size 0.000420356152418843 0.00783247886997657 2.6289429994466 0.5 17.1 17 1 increased skin tumor incidence 0.000420356152418843 0.00783247886997657 2.6289429994466 0.5 17.1 17 1 abnormal blood flow velocity 0.00320434731643561 0.0394594749981861 2.6289429994466 0.5 17.1 17 1 abnormal antigen presentation 0.00320434731643561 0.0394594749981861 2.6289429994466 0.5 17.1 17 1 increased lactate dehydrogenase level 0.00320434731643561 0.0394594749981861 2.6289429994466 0.5 17.1 17 1 increased stomach tumor incidence 0.00320434731643561 0.0394594749981861 2.6289429994466 0.5 17.1 17 1 decreased response to antigen 0.00320434731643561 0.0394594749981861 2.6289429994466 0.5 17.1 17 1 retarded hair growth 0.0129276529357397 0.110888057509147 2.6289429994466 0.5 17.1 17 1 abnormal prostate gland epithelium morphology 0.0129276529357397 0.110888057509147 2.6289429994466 0.5 17.1 17 1 abnormal airway responsiveness 0.0129276529357397 0.110888057509147 2.6289429994466 0.5 17.1 17 1 acrania 0.0129276529357397 0.110888057509147 2.6289429994466 0.5 17.1 17 1 absent CD4-positive, alpha beta T cells 0.0129276529357397 0.110888057509147 2.6289429994466 0.5 17.1 17 1 abnormal developmental vascular remodeling 0.0129276529357397 0.110888057509147 2.6289429994466 0.5 17.1 17 1 absent axillary lymph nodes 0.0129276529357397 0.110888057509147 2.6289429994466 0.5 17.1 17 1 acanthocytosis 0.0129276529357397 0.110888057509147 2.6289429994466 0.5 17.1 17 1 aorta stenosis 0.0129276529357397 0.110888057509147 2.6289429994466 0.5 17.1 17 1 decreased macrophage apoptosis 0.0129276529357397 0.110888057509147 2.6289429994466 0.5 17.1 17 1 abnormal liver development 6.91626870673522e-06 0.000260669975878846 2.55383034231955 0.485714285714286 17.1 17 1 osteopetrosis 2.54765544027388e-05 0.000807298459577232 2.54413838656122 0.483870967741935 17.1 17 1 increased mortality induced by gamma-irradiation 4.90201966576748e-05 0.00140158320903409 2.53828979256913 0.482758620689655 17.1 17 1 decreased trophoblast giant cell number 4.90201966576748e-05 0.00140158320903409 2.53828979256913 0.482758620689655 17.1 17 1 abnormal CD8-positive, alpha-beta T cell physiology 4.90201966576748e-05 0.00140158320903409 2.53828979256913 0.482758620689655 17.1 17 1 abnormal response to infection 2.56861181920877e-11 3.99338868767613e-09 2.5291097209866 0.481012658227848 17.1 17 1 pancreas inflammation 0.000353893065819803 0.00669436502834039 2.51464112990544 0.478260869565217 17.1 17 1 increased susceptibility to fungal infection 0.000353893065819803 0.00669436502834039 2.51464112990544 0.478260869565217 17.1 17 1 abnormal tumor vascularization 0.000687897997077459 0.011561799106285 2.50375523756819 0.476190476190476 17.1 17 1 increased muscle cell glucose uptake 0.000687897997077459 0.011561799106285 2.50375523756819 0.476190476190476 17.1 17 1 increased B cell proliferation 1.51289509858316e-08 1.14040198718958e-06 2.49526793167813 0.474576271186441 17.1 17 1 abnormal inflammatory response 5.26912994935234e-10 5.34977989755671e-08 2.48289061058845 0.472222222222222 17.1 17 1 decreased cytotoxic T cell cytolysis 2.13387309329387e-05 0.000689351859684222 2.4742992935968 0.470588235294118 17.1 17 1 abnormal ectoplacental cone morphology 0.00263071107522547 0.0339942535045369 2.4742992935968 0.470588235294118 17.1 17 1 abnormal respiratory system physiology 3.71249596395305e-07 2.05218526896294e-05 2.46798730560293 0.469387755102041 17.1 17 1 increased leukocyte cell number 2.38425282340259e-18 1.18616577964279e-15 2.46576722706715 0.468965517241379 17.1 17 1 decreased susceptibility to parasitic infection 4.08761649118308e-05 0.00120330722151691 2.46463406198118 0.46875 17.1 17 1 neuron degeneration 7.05017109317881e-07 3.54288900894592e-05 2.46113812714149 0.468085106382979 17.1 17 1 salivary gland inflammation 7.84124915853586e-05 0.00205316918756399 2.45368013281682 0.466666666666667 17.1 17 1 abnormal microglial cell physiology 7.84124915853586e-05 0.00205316918756399 2.45368013281682 0.466666666666667 17.1 17 1 abnormal prostate gland morphology 0.00518525677820044 0.0553576233295004 2.45368013281682 0.466666666666667 17.1 17 1 increased airway responsiveness 0.00518525677820044 0.0553576233295004 2.45368013281682 0.466666666666667 17.1 17 1 abnormal respiratory system morphology 0.00518525677820044 0.0553576233295004 2.45368013281682 0.466666666666667 17.1 17 1 abnormal energy homeostasis 0.00518525677820044 0.0553576233295004 2.45368013281682 0.466666666666667 17.1 17 1 abnormal microglial cell activation 0.00518525677820044 0.0553576233295004 2.45368013281682 0.466666666666667 17.1 17 1 decreased T cell proliferation 2.00499688408202e-18 1.10831772203423e-15 2.4513117157002 0.466216216216216 17.1 17 1 lymphoid hyperplasia 0.000150657804959435 0.00339150488539904 2.44116135662898 0.464285714285714 17.1 17 1 abnormal spleen germinal center morphology 0.000150657804959435 0.00339150488539904 2.44116135662898 0.464285714285714 17.1 17 1 increased bone resorption 0.000150657804959435 0.00339150488539904 2.44116135662898 0.464285714285714 17.1 17 1 abnormal response to injury 9.22089088646974e-06 0.000332419798262224 2.42671661487378 0.461538461538462 17.1 17 1 increased leukemia incidence 0.000289988906913851 0.00584086968379112 2.42671661487378 0.461538461538462 17.1 17 1 abnormal mast cell morphology 0.0102928728247797 0.0931037132786891 2.42671661487378 0.461538461538462 17.1 17 1 abnormal lung interstitium morphology 0.0102928728247797 0.0931037132786891 2.42671661487378 0.461538461538462 17.1 17 1 abnormal coping response 0.0102928728247797 0.0931037132786891 2.42671661487378 0.461538461538462 17.1 17 1 axonal dystrophy 0.0102928728247797 0.0931037132786891 2.42671661487378 0.461538461538462 17.1 17 1 abnormal cytokine secretion 1.4003081192028e-18 8.70816611629239e-16 2.42409029819102 0.461038961038961 17.1 17 1 abnormal vasodilation 0.000559325557841005 0.00979804454316549 2.40986441615938 0.458333333333333 17.1 17 1 impaired natural killer cell mediated cytotoxicity 1.34146892713582e-07 8.78132620065879e-06 2.39833396440742 0.456140350877193 17.1 17 1 lung inflammation 4.01701399204165e-16 1.42747461502909e-13 2.3969774406719 0.455882352941176 17.1 17 1 decreased macrophage cell number 3.96782391425278e-06 0.000163139867548823 2.38994818131509 0.454545454545455 17.1 17 1 increased osteoblast cell number 6.38864225910996e-05 0.00173680301852853 2.38994818131509 0.454545454545455 17.1 17 1 intestinal inflammation 0.00108137066665016 0.0169176700207061 2.38994818131509 0.454545454545455 17.1 17 1 impaired myelopoiesis 0.0206199567343043 0.150196610180328 2.38994818131509 0.454545454545455 17.1 17 1 vasculitis 0.0206199567343043 0.150196610180328 2.38994818131509 0.454545454545455 17.1 17 1 patent ductus arteriosus 0.0206199567343043 0.150196610180328 2.38994818131509 0.454545454545455 17.1 17 1 loss of cortex neurons 0.0206199567343043 0.150196610180328 2.38994818131509 0.454545454545455 17.1 17 1 rectal hemorrhage 0.0206199567343043 0.150196610180328 2.38994818131509 0.454545454545455 17.1 17 1 impaired luteinization 0.0206199567343043 0.150196610180328 2.38994818131509 0.454545454545455 17.1 17 1 pathological neovascularization 0.0206199567343043 0.150196610180328 2.38994818131509 0.454545454545455 17.1 17 1 abnormal superovulation 0.0206199567343043 0.150196610180328 2.38994818131509 0.454545454545455 17.1 17 1 abnormal palate development 0.0206199567343043 0.150196610180328 2.38994818131509 0.454545454545455 17.1 17 1 abnormal dendritic cell chemotaxis 0.0206199567343043 0.150196610180328 2.38994818131509 0.454545454545455 17.1 17 1 chylous ascites 0.0206199567343043 0.150196610180328 2.38994818131509 0.454545454545455 17.1 17 1 decreased IgM level 8.86666646094921e-12 1.5210919187318e-09 2.38502045310619 0.45360824742268 17.1 17 1 decreased lymphocyte cell number 4.94332257170004e-15 1.44664881142398e-12 2.38247959324848 0.453125 17.1 17 1 extramedullary hematopoiesis 1.1066836186719e-12 2.3938047838664e-10 2.38092950893277 0.452830188679245 17.1 17 1 abnormal Peyer's patch T cell area morphology 0.00209639804105625 0.0279613411642222 2.36604869950194 0.45 17.1 17 1 abnormal physiological neovascularization 0.00209639804105625 0.0279613411642222 2.36604869950194 0.45 17.1 17 1 abnormal thymocyte activation 0.00209639804105625 0.0279613411642222 2.36604869950194 0.45 17.1 17 1 abnormal microglial cell morphology 0.000233238361704615 0.00483483687283524 2.35698337881419 0.448275862068966 17.1 17 1 enlarged epididymis 0.000233238361704615 0.00483483687283524 2.35698337881419 0.448275862068966 17.1 17 1 pale liver 5.8131707076187e-09 4.9313737311121e-07 2.34473294545237 0.445945945945946 17.1 17 1 abnormal T cell activation 5.8131707076187e-09 4.9313737311121e-07 2.34473294545237 0.445945945945946 17.1 17 1 abnormal cell migration 6.07044684712948e-06 0.000232311331265147 2.33683822173031 0.444444444444444 17.1 17 1 absent inner cell mass 0.00407720978184824 0.0464329991685635 2.33683822173031 0.444444444444444 17.1 17 1 abnormal pregnancy 0.00407720978184824 0.0464329991685635 2.33683822173031 0.444444444444444 17.1 17 1 abnormal macrophage chemotaxis 0.00407720978184824 0.0464329991685635 2.33683822173031 0.444444444444444 17.1 17 1 impaired leukocyte tethering or rolling 0.00407720978184824 0.0464329991685635 2.33683822173031 0.444444444444444 17.1 17 1 increased adipocyte glucose uptake 0.00407720978184824 0.0464329991685635 2.33683822173031 0.444444444444444 17.1 17 1 liver hypoplasia 1.37331774293441e-06 6.56947670297952e-05 2.32560342258737 0.442307692307692 17.1 17 1 increased inflammatory response 7.22018510843624e-11 8.76107827182203e-09 2.32453907319489 0.442105263157895 17.1 17 1 increased neutrophil cell number 9.55449371369805e-16 3.16890708170985e-13 2.3207220960632 0.441379310344828 17.1 17 1 enlarged liver sinusoidal spaces 9.74767054791217e-05 0.00244922530181126 2.319655587747 0.441176470588235 17.1 17 1 increased monocyte cell number 3.12656431536147e-11 4.57489925556569e-09 2.313469839513 0.44 17.1 17 1 abnormal cell differentiation 2.16358015479519e-05 0.000694439436781036 2.30834019463604 0.439024390243902 17.1 17 1 abnormal bone marrow cell number 0.00795964386879534 0.075715541581753 2.30032512451577 0.4375 17.1 17 1 abnormal hair follicle orientation 0.00795964386879534 0.075715541581753 2.30032512451577 0.4375 17.1 17 1 disorganized yolk sac vascular plexus 0.00795964386879534 0.075715541581753 2.30032512451577 0.4375 17.1 17 1 intraventricular hemorrhage 0.00795964386879534 0.075715541581753 2.30032512451577 0.4375 17.1 17 1 increased B cell number 1.35881120364145e-12 2.81670239088176e-10 2.29189902515857 0.435897435897436 17.1 17 1 abnormal cell death 9.12944676619758e-06 0.000331525530378343 2.28603739082313 0.434782608695652 17.1 17 1 liver inflammation 1.08991838048667e-12 2.3938047838664e-10 2.27841726618705 0.433333333333333 17.1 17 1 abnormal spleen marginal zone morphology 0.00035163461532522 0.00669436502834039 2.27841726618705 0.433333333333333 17.1 17 1 abnormal fat pad morphology 0.00035163461532522 0.00669436502834039 2.27841726618705 0.433333333333333 17.1 17 1 decreased IgG level 8.70699923406912e-12 1.5210919187318e-09 2.27368043195381 0.432432432432432 17.1 17 1 abnormal humoral immune response 5.55226110582701e-11 7.4655402706728e-09 2.25337971381137 0.428571428571429 17.1 17 1 decreased inflammatory response 4.48892702152716e-09 3.98793070216029e-07 2.25337971381137 0.428571428571429 17.1 17 1 abnormal spleen white pulp morphology 3.22213037297497e-05 0.000983441632242361 2.25337971381137 0.428571428571429 17.1 17 1 absent visceral yolk sac blood islands 0.0156092669560378 0.12287358086438 2.25337971381137 0.428571428571429 17.1 17 1 amyloid beta deposits 0.0156092669560378 0.12287358086438 2.25337971381137 0.428571428571429 17.1 17 1 failure of zygotic cell division 0.0156092669560378 0.12287358086438 2.25337971381137 0.428571428571429 17.1 17 1 abnormal sagittal suture morphology 0.0156092669560378 0.12287358086438 2.25337971381137 0.428571428571429 17.1 17 1 abnormal decidualization 0.0156092669560378 0.12287358086438 2.25337971381137 0.428571428571429 17.1 17 1 split sternum 0.0156092669560378 0.12287358086438 2.25337971381137 0.428571428571429 17.1 17 1 abnormal positive T cell selection 0.0156092669560378 0.12287358086438 2.25337971381137 0.428571428571429 17.1 17 1 increased B-1 B cell number 0.0156092669560378 0.12287358086438 2.25337971381137 0.428571428571429 17.1 17 1 decreased neutrophil cell number 5.5360882370676e-12 1.02153275755775e-09 2.24695982858683 0.427350427350427 17.1 17 1 abnormal cell cycle 1.02399261535339e-11 1.69812108712771e-09 2.24031664300666 0.426086956521739 17.1 17 1 decreased platelet aggregation 3.04636036781214e-06 0.000130652093360909 2.23946996249155 0.425925925925926 17.1 17 1 decreased sensitivity to xenobiotic induced morbidity/mortality 0.000274429843593124 0.00554995313770646 2.23061830256075 0.424242424242424 17.1 17 1 increased macrophage cell number 2.39349678477457e-06 0.000107232777000713 2.21384673637608 0.421052631578947 17.1 17 1 abnormal triglyceride level 0.00606632293870557 0.0638054051164063 2.21384673637608 0.421052631578947 17.1 17 1 altered susceptibility to infection 0.00606632293870557 0.0638054051164063 2.21384673637608 0.421052631578947 17.1 17 1 increased susceptibility to ischemic brain injury 0.00606632293870557 0.0638054051164063 2.21384673637608 0.421052631578947 17.1 17 1 pale kidney 0.000517476931597357 0.0091944561953459 2.20491993501973 0.419354838709677 17.1 17 1 abnormal T cell proliferation 0.000517476931597357 0.0091944561953459 2.20491993501973 0.419354838709677 17.1 17 1 increased granulocyte number 9.79844027386553e-08 6.58746491384878e-06 2.20262791845526 0.418918918918919 17.1 17 1 abnormal T-helper 2 physiology 4.4458848426318e-06 0.000179823390992628 2.19875232680988 0.418181818181818 17.1 17 1 abnormal osteoclast morphology 1.96912852288013e-05 0.000640288522962657 2.19078583287216 0.416666666666667 17.1 17 1 abnormal trophoblast giant cell morphology 0.000212701975811718 0.00450294608367361 2.19078583287216 0.416666666666667 17.1 17 1 abnormal lysosome morphology 0.000212701975811718 0.00450294608367361 2.19078583287216 0.416666666666667 17.1 17 1 abnormal adrenal gland morphology 0.00241357115205936 0.0315987275828824 2.19078583287216 0.416666666666667 17.1 17 1 abnormal tumor morphology 0.00241357115205936 0.0315987275828824 2.19078583287216 0.416666666666667 17.1 17 1 amyloidosis 0.0307773906506055 0.191720793696163 2.19078583287216 0.416666666666667 17.1 17 1 loss of dopaminergic neurons 0.0307773906506055 0.191720793696163 2.19078583287216 0.416666666666667 17.1 17 1 stria vascularis degeneration 0.0307773906506055 0.191720793696163 2.19078583287216 0.416666666666667 17.1 17 1 abnormal palatine bone morphology 0.0307773906506055 0.191720793696163 2.19078583287216 0.416666666666667 17.1 17 1 abnormal thymus corticomedullary boundary morphology 0.0307773906506055 0.191720793696163 2.19078583287216 0.416666666666667 17.1 17 1 decreased mammary gland epithelial cell proliferation 0.0307773906506055 0.191720793696163 2.19078583287216 0.416666666666667 17.1 17 1 increased type II pneumocyte number 0.0307773906506055 0.191720793696163 2.19078583287216 0.416666666666667 17.1 17 1 decreased granulocyte number 0.000975157573475829 0.0157003525179361 2.17567696505925 0.413793103448276 17.1 17 1 abnormal embryonic erythropoiesis 0.000975157573475829 0.0157003525179361 2.17567696505925 0.413793103448276 17.1 17 1 decreased B cell number 3.54142765970986e-18 1.60169114609605e-15 2.16951606750447 0.412621359223301 17.1 17 1 abnormal trophoblast layer morphology 1.52872817796393e-05 0.000513879911173685 2.1650118818972 0.411764705882353 17.1 17 1 abnormal adipose tissue morphology 0.0116898968242943 0.1038522083944 2.1650118818972 0.411764705882353 17.1 17 1 abnormal bone marrow cavity morphology 0.0116898968242943 0.1038522083944 2.1650118818972 0.411764705882353 17.1 17 1 decreased bone marrow cell number 2.60474348173666e-07 1.54269033590951e-05 2.1607750680383 0.410958904109589 17.1 17 1 enlarged spleen 2.40400047070693e-24 5.16518523249431e-21 2.15427273565763 0.409722222222222 17.1 17 1 abnormal erythropoiesis 8.34493124883717e-10 8.30320659259299e-08 2.15322950430864 0.40952380952381 17.1 17 1 abnormal vascular branching morphogenesis 0.00458682089454124 0.0508227927624559 2.15095336318358 0.409090909090909 17.1 17 1 abnormal mesenteric lymph node morphology 0.00458682089454124 0.0508227927624559 2.15095336318358 0.409090909090909 17.1 17 1 decreased susceptibility to viral infection induced morbidity/mortality 0.00458682089454124 0.0508227927624559 2.15095336318358 0.409090909090909 17.1 17 1 increased adenoma incidence 0.00458682089454124 0.0508227927624559 2.15095336318358 0.409090909090909 17.1 17 1 impaired humoral immune response 0.00458682089454124 0.0508227927624559 2.15095336318358 0.409090909090909 17.1 17 1 abnormal CD4-positive, alpha-beta T cell physiology 4.78853510333436e-07 2.58945240642266e-05 2.14758723898454 0.408450704225352 17.1 17 1 increased T cell derived lymphoma incidence 2.82908945019584e-05 0.000879670000920269 2.14607591791559 0.408163265306122 17.1 17 1 increased spleen weight 2.77090085702279e-10 2.9967895138453e-08 2.14037837123086 0.407079646017699 17.1 17 1 abnormal spongiotrophoblast layer morphology 0.000744886984828907 0.0124774840051307 2.13601618705036 0.40625 17.1 17 1 decreased width of hypertrophic chondrocyte zone 0.000305165848741471 0.00609718914654144 2.1315754049567 0.405405405405405 17.1 17 1 skin inflammation 0.000305165848741471 0.00609718914654144 2.1315754049567 0.405405405405405 17.1 17 1 abnormal nervous system morphology 1.57052265022566e-07 1.00171156216316e-05 2.12977660714661 0.40506329113924 17.1 17 1 abnormal cytotoxic T cell physiology 0.000125940842580139 0.00297227067957101 2.12819195193296 0.404761904761905 17.1 17 1 abnormal immune system physiology 7.13771578186107e-11 8.76107827182203e-09 2.12011532213435 0.403225806451613 17.1 17 1 increased eosinophil cell number 3.82906758982719e-06 0.000158746760494919 2.12011532213435 0.403225806451613 17.1 17 1 increased T cell proliferation 1.67931606753199e-09 1.57633913886257e-07 2.11298222385427 0.401869158878505 17.1 17 1 decreased double-positive T cell number 7.1819509595379e-09 5.95503433728351e-07 2.10315439955728 0.4 17.1 17 1 trabecula carnea hypoplasia 9.64100277364475e-05 0.0024347202435981 2.10315439955728 0.4 17.1 17 1 abnormal myocardial trabeculae morphology 9.64100277364475e-05 0.0024347202435981 2.10315439955728 0.4 17.1 17 1 small placenta 9.64100277364475e-05 0.0024347202435981 2.10315439955728 0.4 17.1 17 1 increased metastatic potential 0.00139083954557623 0.0210316922165402 2.10315439955728 0.4 17.1 17 1 abnormal lactation 0.00139083954557623 0.0210316922165402 2.10315439955728 0.4 17.1 17 1 decreased hepatocyte number 0.022558607074596 0.161140704356292 2.10315439955728 0.4 17.1 17 1 placental labyrinth hypoplasia 0.022558607074596 0.161140704356292 2.10315439955728 0.4 17.1 17 1 abnormal coronary vessel morphology 0.022558607074596 0.161140704356292 2.10315439955728 0.4 17.1 17 1 decreased monocyte cell number 2.94926875846148e-06 0.000127587931072573 2.10315439955728 0.4 17.1 17 1 thick pulmonary interalveolar septum 0.000566847558536562 0.00982601604083413 2.10315439955728 0.4 17.1 17 1 increased carcinoma incidence 0.000566847558536562 0.00982601604083413 2.10315439955728 0.4 17.1 17 1 abnormal induced retinal neovascularization 0.00871293953713843 0.0813262180061233 2.10315439955728 0.4 17.1 17 1 abnormal sperm mitochondrial sheath morphology 0.00871293953713843 0.0813262180061233 2.10315439955728 0.4 17.1 17 1 abnormal neuron proliferation 0.00871293953713843 0.0813262180061233 2.10315439955728 0.4 17.1 17 1 pale yolk sac 1.70915759139591e-07 1.07633658445502e-05 2.09048479474067 0.397590361445783 17.1 17 1 abnormal T cell differentiation 1.00618199769688e-08 7.90999467486264e-07 2.08233108867057 0.396039603960396 17.1 17 1 abnormal homeostasis 0.000177445459809942 0.00388894785266282 2.0786991158415 0.395348837209302 17.1 17 1 abnormal vascular development 4.12896826016832e-06 0.000168373910609323 2.07128842380641 0.393939393939394 17.1 17 1 decreased brown adipose tissue amount 0.00105068412663217 0.0164894433122872 2.07128842380641 0.393939393939394 17.1 17 1 abnormal NK cell physiology 9.8233336895807e-06 0.000346603440465702 2.06867645858093 0.39344262295082 17.1 17 1 abnormal brainstem morphology 0.00259165147364905 0.0335767345869896 2.06559807099375 0.392857142857143 17.1 17 1 abnormal mitotic spindle morphology 0.00259165147364905 0.0335767345869896 2.06559807099375 0.392857142857143 17.1 17 1 abnormal postnatal growth 0.00648058294173097 0.06633930068953 2.05743365174082 0.391304347826087 17.1 17 1 dilated heart 0.00648058294173097 0.06633930068953 2.05743365174082 0.391304347826087 17.1 17 1 hemopericardium 0.000325808978193037 0.00640671804944805 2.05185795078759 0.390243902439024 17.1 17 1 hydrops fetalis 2.41408462795574e-06 0.000107232777000713 2.04473344401402 0.388888888888889 17.1 17 1 increased susceptibility to bacterial infection induced morbidity/mortality 2.41408462795574e-06 0.000107232777000713 2.04473344401402 0.388888888888889 17.1 17 1 underdeveloped hair follicles 0.0165343340331235 0.127138039899211 2.04473344401402 0.388888888888889 17.1 17 1 abnormal thymus medulla morphology 0.0165343340331235 0.127138039899211 2.04473344401402 0.388888888888889 17.1 17 1 abnormal neutrophil morphology 0.0165343340331235 0.127138039899211 2.04473344401402 0.388888888888889 17.1 17 1 abnormal glycogen homeostasis 0.0165343340331235 0.127138039899211 2.04473344401402 0.388888888888889 17.1 17 1 increased gastrointestinal tumor incidence 0.0165343340331235 0.127138039899211 2.04473344401402 0.388888888888889 17.1 17 1 increased effector memory CD4-positive, alpha-beta T cell number 0.0165343340331235 0.127138039899211 2.04473344401402 0.388888888888889 17.1 17 1 decreased tumor growth/size 4.26864094873221e-05 0.00124920521882016 2.04473344401402 0.388888888888889 17.1 17 1 inner cell mass degeneration 0.00194243698598393 0.0261908284024589 2.03531070924898 0.387096774193548 17.1 17 1 abnormal myelopoiesis 0.000246388252338345 0.00506521303877383 2.03145595411782 0.386363636363636 17.1 17 1 thrombocytopenia 4.03878842367295e-11 5.74084925936369e-09 2.0306318340553 0.386206896551724 17.1 17 1 abnormal B cell differentiation 1.92739762656679e-07 1.18380286323084e-05 2.02226384572815 0.384615384615385 17.1 17 1 decreased IgA level 7.75468272997555e-05 0.00205210354157598 2.02226384572815 0.384615384615385 17.1 17 1 abnormal placenta vasculature 7.75468272997555e-05 0.00205210354157598 2.02226384572815 0.384615384615385 17.1 17 1 increased autoantibody level 0.000596546853480282 0.0102672558027964 2.02226384572815 0.384615384615385 17.1 17 1 decreased Peyer's patch number 0.00481653025104772 0.052664259338379 2.02226384572815 0.384615384615385 17.1 17 1 increased thymocyte apoptosis 0.00481653025104772 0.052664259338379 2.02226384572815 0.384615384615385 17.1 17 1 absent teeth 0.0435802142917466 0.247501787787031 2.02226384572815 0.384615384615385 17.1 17 1 absent myocardial trabeculae 0.0435802142917466 0.247501787787031 2.02226384572815 0.384615384615385 17.1 17 1 abnormal telomere length 0.0435802142917466 0.247501787787031 2.02226384572815 0.384615384615385 17.1 17 1 tracheoesophageal fistula 0.0435802142917466 0.247501787787031 2.02226384572815 0.384615384615385 17.1 17 1 orthokeratosis 0.0435802142917466 0.247501787787031 2.02226384572815 0.384615384615385 17.1 17 1 abnormal aorta tunica media morphology 0.0435802142917466 0.247501787787031 2.02226384572815 0.384615384615385 17.1 17 1 lethality throughout fetal growth and development, complete penetrance 6.57107033042006e-14 1.72058288914946e-11 2.02013514694317 0.384210526315789 17.1 17 1 thymus hypoplasia 1.69114508953028e-10 1.91214700463935e-08 2.01933302856043 0.384057971014493 17.1 17 1 seminiferous tubule degeneration 3.32133375932543e-06 0.000140030808920712 2.01672339683575 0.383561643835616 17.1 17 1 abnormal T-helper 1 physiology 0.00018611683797683 0.00404336798661453 2.01365846766122 0.382978723404255 17.1 17 1 decreased bone trabecula number 0.00018611683797683 0.00404336798661453 2.01365846766122 0.382978723404255 17.1 17 1 decreased regulatory T cell number 0.00145454279914028 0.0217962362220569 2.0103681760474 0.382352941176471 17.1 17 1 disheveled coat 0.000448804753954816 0.00830038531942458 2.00300419005455 0.380952380952381 17.1 17 1 abnormal hematopoietic system physiology 0.0121345804375065 0.106471847754135 2.00300419005455 0.380952380952381 17.1 17 1 abnormal erythrocyte physiology 0.0121345804375065 0.106471847754135 2.00300419005455 0.380952380952381 17.1 17 1 increased bone ossification 0.0121345804375065 0.106471847754135 2.00300419005455 0.380952380952381 17.1 17 1 thrombocytosis 4.44104335873411e-05 0.00129205793623989 1.99437055130431 0.379310344827586 17.1 17 1 increased susceptibility to induced arthritis 0.00357950885708824 0.0431292104003621 1.99437055130431 0.379310344827586 17.1 17 1 blood in lymph vessels 0.00357950885708824 0.0431292104003621 1.99437055130431 0.379310344827586 17.1 17 1 decreased T cell number 1.44238735591093e-11 2.31479906311512e-09 1.9921182977173 0.37888198757764 17.1 17 1 increased trabecular bone volume 0.00108867636973884 0.016978573477902 1.98947037795959 0.378378378378378 17.1 17 1 increased double-negative T cell number 3.35729290097914e-05 0.00101844708429093 1.98248160614006 0.377049180327869 17.1 17 1 abnormal definitive hematopoiesis 3.57760532392642e-07 2.00520019779252e-05 1.97877430065873 0.376344086021505 17.1 17 1 decreased body height 0.00892079001553393 0.0826460527509894 1.97170724958495 0.375 17.1 17 1 abnormal intestinal absorption 0.0313179849980764 0.191720793696163 1.97170724958495 0.375 17.1 17 1 small pancreas 0.0313179849980764 0.191720793696163 1.97170724958495 0.375 17.1 17 1 sepsis 0.0313179849980764 0.191720793696163 1.97170724958495 0.375 17.1 17 1 dystonia 0.0313179849980764 0.191720793696163 1.97170724958495 0.375 17.1 17 1 abnormal Langerhans cell physiology 0.0313179849980764 0.191720793696163 1.97170724958495 0.375 17.1 17 1 decreased circulating triiodothyronine level 0.0313179849980764 0.191720793696163 1.97170724958495 0.375 17.1 17 1 decreased liver cholesterol level 0.0313179849980764 0.191720793696163 1.97170724958495 0.375 17.1 17 1 abnormal pulmonary alveolus wall morphology 0.0313179849980764 0.191720793696163 1.97170724958495 0.375 17.1 17 1 abnormal double-strand DNA break repair 0.000609610261596231 0.0103863392172645 1.95642269726258 0.372093023255814 17.1 17 1 abnormal apoptosis 0.000143160419794594 0.00327196084131699 1.94736518477526 0.37037037037037 17.1 17 1 abnormal palate morphology 0.00656978760931835 0.0667034558293037 1.94736518477526 0.37037037037037 17.1 17 1 thick interventricular septum 0.00656978760931835 0.0667034558293037 1.94736518477526 0.37037037037037 17.1 17 1 anemia 1.03858415157862e-13 2.46045531147793e-11 1.94367349722118 0.369668246445498 17.1 17 1 abnormal myelin sheath morphology 0.000456205523586422 0.00834420029353841 1.94313178219966 0.369565217391304 17.1 17 1 abnormal hepatocyte morphology 6.8169119544219e-08 4.71029680184014e-06 1.94210203562722 0.369369369369369 17.1 17 1 absent vitelline blood vessels 0.000107542596413448 0.0026466486513883 1.93711589432907 0.368421052631579 17.1 17 1 decreased hair follicle number 0.00147279775715889 0.0218721457966134 1.93711589432907 0.368421052631579 17.1 17 1 enlarged adrenal glands 0.0226406738382007 0.161140704356292 1.93711589432907 0.368421052631579 17.1 17 1 short vibrissae 0.0226406738382007 0.161140704356292 1.93711589432907 0.368421052631579 17.1 17 1 abnormal stationary movement 0.0226406738382007 0.161140704356292 1.93711589432907 0.368421052631579 17.1 17 1 decreased susceptibility to weight gain 0.0226406738382007 0.161140704356292 1.93711589432907 0.368421052631579 17.1 17 1 abnormal placenta morphology 6.21545829722516e-06 0.000236045076554925 1.93011005022662 0.367088607594937 17.1 17 1 increased erythrocyte cell number 8.0784893909683e-05 0.00208240853471851 1.9278915329275 0.366666666666667 17.1 17 1 gastrointestinal hemorrhage 0.00484663319533204 0.0526945433728594 1.9278915329275 0.366666666666667 17.1 17 1 arrested T cell differentiation 0.00484663319533204 0.0526945433728594 1.9278915329275 0.366666666666667 17.1 17 1 sparse hair 4.68861938331786e-06 0.000186607051456051 1.92361682886336 0.365853658536585 17.1 17 1 arrested B cell differentiation 0.00109670536556568 0.0169972249024587 1.92361682886336 0.365853658536585 17.1 17 1 increased bone trabecula number 0.00109670536556568 0.0169972249024587 1.92361682886336 0.365853658536585 17.1 17 1 increased T cell number 2.6670987730617e-06 0.000116393126280544 1.91195854505207 0.363636363636364 17.1 17 1 abnormal platelet physiology 0.000191418795929189 0.0041404717815118 1.91195854505207 0.363636363636364 17.1 17 1 abnormal skeleton physiology 0.00358112862098826 0.0431292104003621 1.91195854505207 0.363636363636364 17.1 17 1 increased cardiomyocyte apoptosis 0.00358112862098826 0.0431292104003621 1.91195854505207 0.363636363636364 17.1 17 1 abnormal long bone epiphysis morphology 0.0164475858906294 0.127138039899211 1.91195854505207 0.363636363636364 17.1 17 1 increased activated T cell number 0.0164475858906294 0.127138039899211 1.91195854505207 0.363636363636364 17.1 17 1 prolonged PR interval 0.0164475858906294 0.127138039899211 1.91195854505207 0.363636363636364 17.1 17 1 pulmonary vascular congestion 0.0164475858906294 0.127138039899211 1.91195854505207 0.363636363636364 17.1 17 1 increased bone volume 0.0164475858906294 0.127138039899211 1.91195854505207 0.363636363636364 17.1 17 1 increased mean corpuscular hemoglobin 6.5163478443303e-07 3.37696151307742e-05 1.91195854505207 0.363636363636364 17.1 17 1 microcephaly 3.42524380342008e-05 0.00102654144108523 1.90503115901927 0.36231884057971 17.1 17 1 increased lymphocyte cell number 3.42524380342008e-05 0.00102654144108523 1.90503115901927 0.36231884057971 17.1 17 1 abnormal spleen morphology 6.43630302498323e-11 8.21041219212604e-09 1.90371734442685 0.362068965517241 17.1 17 1 abnormal embryonic neuroepithelium morphology 0.000143374364503941 0.00327196084131699 1.90371734442685 0.362068965517241 17.1 17 1 abnormal cell nucleus morphology 0.000609255778765189 0.0103863392172645 1.90178855279115 0.361702127659574 17.1 17 1 increased osteoclast cell number 0.000107417284366032 0.0026466486513883 1.89628675369918 0.360655737704918 17.1 17 1 short stride length 0.000454516968228897 0.00834399231342717 1.89283895960155 0.36 17.1 17 1 increased B cell derived lymphoma incidence 0.000454516968228897 0.00834399231342717 1.89283895960155 0.36 17.1 17 1 abnormal egg cylinder morphology 0.0119967466136976 0.105822365963024 1.89283895960155 0.36 17.1 17 1 increased pre-B cell number 0.0119967466136976 0.105822365963024 1.89283895960155 0.36 17.1 17 1 abnormal keratinocyte physiology 0.0119967466136976 0.105822365963024 1.89283895960155 0.36 17.1 17 1 decreased acute inflammation 0.0119967466136976 0.105822365963024 1.89283895960155 0.36 17.1 17 1 abnormal osteoclast physiology 8.0499582462897e-05 0.00208240853471851 1.88955278085224 0.359375 17.1 17 1 increased hepatocyte apoptosis 0.00196349826321891 0.0264010915122002 1.88744625601294 0.358974358974359 17.1 17 1 abnormal placenta development 0.00033927397166412 0.00659331253526952 1.88490252790511 0.358490566037736 17.1 17 1 atrioventricular septal defect 0.00033927397166412 0.00659331253526952 1.88490252790511 0.358490566037736 17.1 17 1 increased triglyceride level 0.00877986324024578 0.0814922007839976 1.87781642817614 0.357142857142857 17.1 17 1 abnormal renal tubule epithelium morphology 0.00877986324024578 0.0814922007839976 1.87781642817614 0.357142857142857 17.1 17 1 subcutaneous edema 0.00877986324024578 0.0814922007839976 1.87781642817614 0.357142857142857 17.1 17 1 absent atrioventricular cushions 0.0591196294782515 0.309274612675396 1.87781642817614 0.357142857142857 17.1 17 1 abnormal fluid regulation 0.0591196294782515 0.309274612675396 1.87781642817614 0.357142857142857 17.1 17 1 intestinal obstruction 0.0591196294782515 0.309274612675396 1.87781642817614 0.357142857142857 17.1 17 1 abnormal pancreas development 0.0591196294782515 0.309274612675396 1.87781642817614 0.357142857142857 17.1 17 1 increased circulating growth hormone level 0.0591196294782515 0.309274612675396 1.87781642817614 0.357142857142857 17.1 17 1 pulmonary alveolar hemorrhage 0.0591196294782515 0.309274612675396 1.87781642817614 0.357142857142857 17.1 17 1 decreased compact bone area 0.0591196294782515 0.309274612675396 1.87781642817614 0.357142857142857 17.1 17 1 testis degeneration 0.0591196294782515 0.309274612675396 1.87781642817614 0.357142857142857 17.1 17 1 abnormal nervous system physiology 2.10096172788432e-07 1.27466885319811e-05 1.87455066047496 0.356521739130435 17.1 17 1 double outlet right ventricle 6.43640499879651e-07 3.37064367042238e-05 1.86728661642936 0.355140186915888 17.1 17 1 autoimmune response 0.0064439411104735 0.0662367913731522 1.86570148347823 0.354838709677419 17.1 17 1 abnormal lipid homeostasis 5.11848350755925e-08 3.58654302114187e-06 1.8604827380699 0.353846153846154 17.1 17 1 failure of chorioallantoic fusion 0.000598493303077579 0.0102672558027964 1.8557244701976 0.352941176470588 17.1 17 1 abnormal dorsal-ventral axis patterning 0.0420242149110485 0.240587421383736 1.8557244701976 0.352941176470588 17.1 17 1 pancytopenia 0.0420242149110485 0.240587421383736 1.8557244701976 0.352941176470588 17.1 17 1 enhanced behavioral response to cocaine 0.0420242149110485 0.240587421383736 1.8557244701976 0.352941176470588 17.1 17 1 abnormal cell cytoskeleton morphology 0.0420242149110485 0.240587421383736 1.8557244701976 0.352941176470588 17.1 17 1 abnormal branching of the mammary ductal tree 0.0034956145087002 0.0426242210313321 1.84736535096247 0.351351351351351 17.1 17 1 decreased erythrocyte cell number 4.03122266771168e-09 3.6464241403392e-07 1.84193458559953 0.35031847133758 17.1 17 1 decreased circulating VLDL cholesterol level 0.0301402230772342 0.191720793696163 1.84026009961262 0.35 17.1 17 1 decreased hematocrit 1.62068237191685e-08 1.2034171343711e-06 1.83665880783255 0.349315068493151 17.1 17 1 increased bone mineral content 1.09304920040328e-06 5.38407898218447e-05 1.83302447667836 0.348623853211009 17.1 17 1 abnormal B cell morphology 0.0217633207967087 0.15657597162497 1.8288299126585 0.347826086956522 17.1 17 1 abnormal vertebral artery topology 0.0217633207967087 0.15657597162497 1.8288299126585 0.347826086956522 17.1 17 1 abnormal vitelline vasculature morphology 6.18032887950613e-07 3.30614367478957e-05 1.8288299126585 0.347826086956522 17.1 17 1 abnormal long bone hypertrophic chondrocyte zone 0.001050160173632 0.0164894433122872 1.82416453022825 0.346938775510204 17.1 17 1 increased circulating LDL cholesterol level 0.001050160173632 0.0164894433122872 1.82416453022825 0.346938775510204 17.1 17 1 abnormal Schwann cell morphology 0.0157980376292181 0.123967251112556 1.82003746115534 0.346153846153846 17.1 17 1 abnormal embryo turning 0.000579958379257278 0.010018378252795 1.81636061779947 0.345454545454545 17.1 17 1 dermatitis 0.00043162143574275 0.00801237553291112 1.81306413754938 0.344827586206897 17.1 17 1 thin ventricular wall 1.35993146474419e-05 0.000466597174972576 1.81104962184099 0.344444444444444 17.1 17 1 pancreatic islet hyperplasia 0.00842549898484313 0.0798416332373229 1.80739831211954 0.34375 17.1 17 1 spleen hypoplasia 3.23017922525995e-06 0.000137351637997165 1.80270377104909 0.342857142857143 17.1 17 1 ovary cysts 0.00618212515183776 0.0646135979630102 1.80270377104909 0.342857142857143 17.1 17 1 decreased triglyceride level 0.00618212515183776 0.0646135979630102 1.80270377104909 0.342857142857143 17.1 17 1 decreased glycogen level 0.00618212515183776 0.0646135979630102 1.80270377104909 0.342857142857143 17.1 17 1 pallor 2.10857519785887e-09 1.94262252024961e-07 1.80270377104909 0.342857142857143 17.1 17 1 astrocytosis 9.9682338751309e-05 0.00249205846878272 1.80064589003192 0.342465753424658 17.1 17 1 decreased neuron apoptosis 0.00454747921950171 0.0508227927624559 1.79875047330557 0.342105263157895 17.1 17 1 abnormal astrocyte morphology 0.00247589866830578 0.0323296479654101 1.79246113598632 0.340909090909091 17.1 17 1 increased cellular sensitivity to gamma-irradiation 0.00183164004684516 0.0253827555238291 1.78991863792109 0.340425531914894 17.1 17 1 abnormal interventricular septum morphology 0.0013570066733851 0.020645590825966 1.78768123962369 0.34 17.1 17 1 kidney inflammation 0.0013570066733851 0.020645590825966 1.78768123962369 0.34 17.1 17 1 abnormal angiogenesis 0.000127880035204136 0.0030009583733046 1.77631283746392 0.337837837837838 17.1 17 1 abnormal locomotor behavior 2.23692447829309e-05 0.000713378158942828 1.77167897788792 0.33695652173913 17.1 17 1 decreased leukocyte cell number 3.01586377085656e-07 1.76516732470722e-05 1.76542157627071 0.335766423357664 17.1 17 1 small liver 0.000121671776487382 0.00289625400968769 1.75262866629773 0.333333333333333 17.1 17 1 abnormal gluconeogenesis 0.00173626335853888 0.02440087629585 1.75262866629773 0.333333333333333 17.1 17 1 decreased trabecular bone volume 0.0058394696976431 0.0618114079697328 1.75262866629773 0.333333333333333 17.1 17 1 delayed bone ossification 0.000162960068799577 0.00358728470034468 1.75262866629773 0.333333333333333 17.1 17 1 abnormal neurocranium morphology 0.000162960068799577 0.00358728470034468 1.75262866629773 0.333333333333333 17.1 17 1 decreased susceptibility to hepatic steatosis 0.000528025117308544 0.00934848739718864 1.75262866629773 0.333333333333333 17.1 17 1 overriding aortic valve 0.00234531783532661 0.0309494860232092 1.75262866629773 0.333333333333333 17.1 17 1 vertebral transformation 0.00234531783532661 0.0309494860232092 1.75262866629773 0.333333333333333 17.1 17 1 abnormal brain vasculature morphology 0.0148520211967743 0.121154119704157 1.75262866629773 0.333333333333333 17.1 17 1 abnormal primitive streak formation 0.028184586187296 0.180461153515827 1.75262866629773 0.333333333333333 17.1 17 1 increased body temperature 0.028184586187296 0.180461153515827 1.75262866629773 0.333333333333333 17.1 17 1 abnormal inner cell mass apoptosis 0.028184586187296 0.180461153515827 1.75262866629773 0.333333333333333 17.1 17 1 abnormal truncus arteriosus septation 0.028184586187296 0.180461153515827 1.75262866629773 0.333333333333333 17.1 17 1 abnormal mammary gland morphology 0.054769155350011 0.296780111078577 1.75262866629773 0.333333333333333 17.1 17 1 abnormal bile duct morphology 0.054769155350011 0.296780111078577 1.75262866629773 0.333333333333333 17.1 17 1 abnormal white adipose tissue morphology 0.054769155350011 0.296780111078577 1.75262866629773 0.333333333333333 17.1 17 1 abnormal redox activity 0.054769155350011 0.296780111078577 1.75262866629773 0.333333333333333 17.1 17 1 decreased cellular sensitivity to gamma-irradiation 0.054769155350011 0.296780111078577 1.75262866629773 0.333333333333333 17.1 17 1 darkened coat color 0.054769155350011 0.296780111078577 1.75262866629773 0.333333333333333 17.1 17 1 decreased lactate dehydrogenase level 0.054769155350011 0.296780111078577 1.75262866629773 0.333333333333333 17.1 17 1 decreased tumor latency 0.054769155350011 0.296780111078577 1.75262866629773 0.333333333333333 17.1 17 1 increased effector memory CD8-positive, alpha-beta T cell number 0.054769155350011 0.296780111078577 1.75262866629773 0.333333333333333 17.1 17 1 abnormal hypoglossal nerve topology 0.054769155350011 0.296780111078577 1.75262866629773 0.333333333333333 17.1 17 1 abnormal fontanelle morphology 0.0774001406800792 0.360548408130519 1.75262866629773 0.333333333333333 17.1 17 1 hyperpigmentation 0.0774001406800792 0.360548408130519 1.75262866629773 0.333333333333333 17.1 17 1 abnormal pericyte morphology 0.0774001406800792 0.360548408130519 1.75262866629773 0.333333333333333 17.1 17 1 abnormal branching involved in lung morphogenesis 0.0774001406800792 0.360548408130519 1.75262866629773 0.333333333333333 17.1 17 1 decreased brown adipose tissue mass 0.0774001406800792 0.360548408130519 1.75262866629773 0.333333333333333 17.1 17 1 abnormal pancreas morphology 0.00430012740400616 0.0484007552826485 1.75262866629773 0.333333333333333 17.1 17 1 thin epidermis 0.020412162639168 0.150196610180328 1.75262866629773 0.333333333333333 17.1 17 1 increased brain weight 0.020412162639168 0.150196610180328 1.75262866629773 0.333333333333333 17.1 17 1 abnormal type II pneumocyte morphology 0.020412162639168 0.150196610180328 1.75262866629773 0.333333333333333 17.1 17 1 liver degeneration 0.0391430443970979 0.231004324882043 1.75262866629773 0.333333333333333 17.1 17 1 abnormal clavicle morphology 0.0391430443970979 0.231004324882043 1.75262866629773 0.333333333333333 17.1 17 1 embryonic lethality during organogenesis, complete penetrance 3.11468456230813e-24 5.16518523249431e-21 1.74636927820381 0.332142857142857 17.1 17 1 embryonic lethality between implantation and somite formation, complete penetrance 2.93015795422658e-11 4.41743509765976e-09 1.73832149351163 0.330612244897959 17.1 17 1 decreased cell proliferation 8.52007840821011e-09 6.83667581949118e-07 1.73368132936478 0.32972972972973 17.1 17 1 abnormal liver morphology 1.50394394829846e-08 1.14040198718958e-06 1.73304622309887 0.329608938547486 17.1 17 1 abnormal somite development 0.000154033730766516 0.00342106165430097 1.73044349330662 0.329113924050633 17.1 17 1 abnormal placenta labyrinth morphology 0.000154033730766516 0.00342106165430097 1.73044349330662 0.329113924050633 17.1 17 1 abnormal myocardium layer morphology 0.000154033730766516 0.00342106165430097 1.73044349330662 0.329113924050633 17.1 17 1 embryonic lethality between somite formation and embryo turning, complete penetrance 0.000370918900128651 0.00698985427325772 1.72759111392205 0.328571428571429 17.1 17 1 decreased circulating calcium level 0.00163117902271068 0.0233560465927119 1.72076269054686 0.327272727272727 17.1 17 1 decreased circulating total protein level 0.00163117902271068 0.0233560465927119 1.72076269054686 0.327272727272727 17.1 17 1 distended pericardium 0.00220072935720767 0.0291963428056218 1.71892426886893 0.326923076923077 17.1 17 1 kinked neural tube 0.00220072935720767 0.0291963428056218 1.71892426886893 0.326923076923077 17.1 17 1 increased sarcoma incidence 0.00297327306523918 0.0372595302256043 1.71686073433247 0.326530612244898 17.1 17 1 failure to gastrulate 0.00402329312771026 0.0464329991685635 1.71452804311735 0.326086956521739 17.1 17 1 abnormal vasculogenesis 0.00545377852116094 0.0579593579010191 1.71186986010476 0.325581395348837 17.1 17 1 delayed endochondral bone ossification 0.00545377852116094 0.0579593579010191 1.71186986010476 0.325581395348837 17.1 17 1 perinatal lethality 0.00740783382794794 0.0722594637226333 1.70881294964029 0.325 17.1 17 1 abnormal pancreatic beta cell morphology 0.00740783382794794 0.0722594637226333 1.70881294964029 0.325 17.1 17 1 decreased birth body size 1.00774439947371e-05 0.000353065379393077 1.7065068592899 0.324561403508772 17.1 17 1 lethality throughout fetal growth and development, incomplete penetrance 3.93942005628318e-08 2.79980211142983e-06 1.70367255830059 0.324022346368715 17.1 17 1 abnormal brown adipose tissue morphology 0.0137682318220974 0.11719473429973 1.7010807643478 0.323529411764706 17.1 17 1 increased susceptibility to viral infection induced morbidity/mortality 0.0137682318220974 0.11719473429973 1.7010807643478 0.323529411764706 17.1 17 1 abnormal object recognition memory 0.0188558688569176 0.141918226268026 1.69609225770748 0.32258064516129 17.1 17 1 abnormal capillary morphology 0.0188558688569176 0.141918226268026 1.69609225770748 0.32258064516129 17.1 17 1 abnormal CD8-positive, alpha beta T cell morphology 0.0188558688569176 0.141918226268026 1.69609225770748 0.32258064516129 17.1 17 1 decreased susceptibility to bacterial infection induced morbidity/mortality 0.0188558688569176 0.141918226268026 1.69609225770748 0.32258064516129 17.1 17 1 abnormal bone mineralization 7.09312699762452e-06 0.000265325615136707 1.69469052856888 0.322314049586777 17.1 17 1 increased hemoglobin content 0.00152149648999019 0.0225281102312536 1.6932175250673 0.322033898305085 17.1 17 1 abnormal skeleton morphology 1.25877456736692e-05 0.00043488913004517 1.69166766920911 0.321739130434783 17.1 17 1 abnormal circulating cholesterol level 0.0259221991965522 0.171472728606868 1.69003478535853 0.321428571428571 17.1 17 1 failure of blastocyst to hatch from the zona pellucida 0.0259221991965522 0.171472728606868 1.69003478535853 0.321428571428571 17.1 17 1 abnormal heart ventricle morphology 0.000324659675770472 0.00640671804944805 1.68521987144013 0.320512820512821 17.1 17 1 diaphragmatic hernia 0.0358023930454601 0.212803949105333 1.68252351964582 0.32 17.1 17 1 abnormal myocardial fiber morphology 7.080917430845e-05 0.00190419266045697 1.68035531923391 0.319587628865979 17.1 17 1 hepatic necrosis 0.00505063050936577 0.0545051774058453 1.67804872305102 0.319148936170213 17.1 17 1 decreased sensitivity to induced morbidity/mortality 0.00684345578582668 0.0693405143268589 1.67296372692056 0.318181818181818 17.1 17 1 abnormal enterocyte morphology 0.0497342583667833 0.276455793714801 1.67296372692056 0.318181818181818 17.1 17 1 abnormal germ layer development 0.0497342583667833 0.276455793714801 1.67296372692056 0.318181818181818 17.1 17 1 increased skin papilloma incidence 0.0497342583667833 0.276455793714801 1.67296372692056 0.318181818181818 17.1 17 1 abnormal circulating lipid level 0.0497342583667833 0.276455793714801 1.67296372692056 0.318181818181818 17.1 17 1 abnormal blood-brain barrier function 0.0497342583667833 0.276455793714801 1.67296372692056 0.318181818181818 17.1 17 1 skin lesions 0.00141093448374111 0.0212709062321577 1.66917015837879 0.317460317460317 17.1 17 1 abnormal mammary gland development 0.00929075948078708 0.0852795727249367 1.66713458501492 0.317073170731707 17.1 17 1 abnormal cholesterol homeostasis 0.00929075948078708 0.0852795727249367 1.66713458501492 0.317073170731707 17.1 17 1 palatal shelves fail to meet at midline 0.00929075948078708 0.0852795727249367 1.66713458501492 0.317073170731707 17.1 17 1 abnormal eating behavior 0.00189760250954346 0.0260070867354786 1.66499723298284 0.316666666666667 17.1 17 1 cardiac hypertrophy 8.78637381784391e-05 0.00225320668782337 1.66320883638458 0.316326530612245 17.1 17 1 abnormal cell morphology 2.58385024468621e-05 0.00081358575742493 1.66038505228206 0.315789473684211 17.1 17 1 decreased birth weight 0.00011724736733137 0.00281790170277084 1.66038505228206 0.315789473684211 17.1 17 1 decreased brain weight 0.00255476040641855 0.0332720759736447 1.66038505228206 0.315789473684211 17.1 17 1 abnormal compact bone morphology 0.0126414687447928 0.110529537794981 1.66038505228206 0.315789473684211 17.1 17 1 kyphoscoliosis 0.069597685278539 0.329446702436471 1.66038505228206 0.315789473684211 17.1 17 1 small superior vagus ganglion 0.069597685278539 0.329446702436471 1.66038505228206 0.315789473684211 17.1 17 1 increased liver cholesterol level 0.069597685278539 0.329446702436471 1.66038505228206 0.315789473684211 17.1 17 1 thin interventricular septum 0.069597685278539 0.329446702436471 1.66038505228206 0.315789473684211 17.1 17 1 neurodegeneration 0.00344341522168048 0.0420908863092393 1.65526040705897 0.314814814814815 17.1 17 1 abnormal dermal layer morphology 0.0172451973792997 0.130997492093343 1.652478456795 0.314285714285714 17.1 17 1 increased circulating serum albumin level 0.0172451973792997 0.130997492093343 1.652478456795 0.314285714285714 17.1 17 1 abnormal midbrain development 0.0172451973792997 0.130997492093343 1.652478456795 0.314285714285714 17.1 17 1 decreased circulating thyroxine level 0.0172451973792997 0.130997492093343 1.652478456795 0.314285714285714 17.1 17 1 increased red blood cell distribution width 0.0172451973792997 0.130997492093343 1.652478456795 0.314285714285714 17.1 17 1 edema 3.58719231363888e-07 2.00520019779252e-05 1.6507316508153 0.313953488372093 17.1 17 1 decreased embryo size 2.76222785772325e-17 1.1451736326811e-14 1.6499642255941 0.313807531380753 17.1 17 1 cochlear inner hair cell degeneration 0.0046470601712878 0.0511485052038868 1.64953286239786 0.313725490196078 17.1 17 1 abnormal thrombosis 0.0046470601712878 0.0511485052038868 1.64953286239786 0.313725490196078 17.1 17 1 embryonic lethality, complete penetrance 5.54399687518778e-12 1.02153275755775e-09 1.64824012504489 0.313479623824451 17.1 17 1 postnatal lethality 6.31297330090271e-07 3.34117469914798e-05 1.64704862615931 0.313253012048193 17.1 17 1 abnormal neuron morphology 0.000108525894448887 0.0026466486513883 1.64640874712817 0.313131313131313 17.1 17 1 decreased circulating serum albumin level 0.000108525894448887 0.0026466486513883 1.64640874712817 0.313131313131313 17.1 17 1 abnormal testis morphology 3.18768219890768e-05 0.000978933267874426 1.64594692139265 0.31304347826087 17.1 17 1 abnormal lymph node morphology 0.0062803180884745 0.0655022693714059 1.64308937465412 0.3125 17.1 17 1 abnormal crypts of Lieberkuhn morphology 0.023596946071497 0.166517456320138 1.64308937465412 0.3125 17.1 17 1 bradykinesia 0.023596946071497 0.166517456320138 1.64308937465412 0.3125 17.1 17 1 increased fatty acid level 0.023596946071497 0.166517456320138 1.64308937465412 0.3125 17.1 17 1 failure of tooth eruption 0.0983465750809896 0.426107774683257 1.64308937465412 0.3125 17.1 17 1 delayed hair appearance 0.0983465750809896 0.426107774683257 1.64308937465412 0.3125 17.1 17 1 abnormal mouth morphology 0.0983465750809896 0.426107774683257 1.64308937465412 0.3125 17.1 17 1 increased intestinal adenocarcinoma incidence 0.0983465750809896 0.426107774683257 1.64308937465412 0.3125 17.1 17 1 abnormal epicardium morphology 0.0983465750809896 0.426107774683257 1.64308937465412 0.3125 17.1 17 1 large intestinal inflammation 0.0983465750809896 0.426107774683257 1.64308937465412 0.3125 17.1 17 1 increased pancreatic beta cell number 0.0983465750809896 0.426107774683257 1.64308937465412 0.3125 17.1 17 1 increased cochlear outer hair cell number 0.0983465750809896 0.426107774683257 1.64308937465412 0.3125 17.1 17 1 decreased creatinine clearance 0.0983465750809896 0.426107774683257 1.64308937465412 0.3125 17.1 17 1 decreased fibroblast apoptosis 0.0983465750809896 0.426107774683257 1.64308937465412 0.3125 17.1 17 1 decreased adipocyte glucose uptake 0.0983465750809896 0.426107774683257 1.64308937465412 0.3125 17.1 17 1 decreased hemoglobin content 4.94518255166031e-06 0.000193718765311103 1.64075875142766 0.312056737588652 17.1 17 1 oxidative stress 0.000257623716769461 0.00527439502439534 1.63578675521122 0.311111111111111 17.1 17 1 altered response to myocardial infarction 0.00850111312796443 0.0801627233357258 1.63578675521122 0.311111111111111 17.1 17 1 abnormal lung morphology 2.9456799312083e-05 0.000910233394892007 1.63480489041217 0.310924369747899 17.1 17 1 abnormal bone structure 1.22422641974747e-07 8.12070191765819e-06 1.63457595820514 0.310880829015544 17.1 17 1 hemorrhage 5.8482623142837e-09 4.9313737311121e-07 1.63330075710299 0.31063829787234 17.1 17 1 abnormal brain morphology 1.36343465176362e-06 6.56947670297952e-05 1.63288385058795 0.31055900621118 17.1 17 1 decreased bone strength 0.0324045874966685 0.195172908953906 1.63175772379444 0.310344827586207 17.1 17 1 increased double-positive T cell number 0.0324045874966685 0.195172908953906 1.63175772379444 0.310344827586207 17.1 17 1 abnormal heart development 1.80802642012455e-06 8.32864022233298e-05 1.63061021484662 0.310126582278481 17.1 17 1 abnormal embryo size 5.210590642804e-05 0.00148129648273999 1.62854876071913 0.309734513274336 17.1 17 1 spina bifida 0.0115279393772751 0.102964988154297 1.62744090441932 0.30952380952381 17.1 17 1 abnormal learning/memory/conditioning 0.004254152468588 0.0482104977932239 1.62516476329426 0.309090909090909 17.1 17 1 ventricular septal defect 1.06849773358513e-05 0.000371732603117904 1.6237589114229 0.308823529411765 17.1 17 1 abnormal cardiovascular system physiology 1.41827431040527e-05 0.000483281828374398 1.62085207484677 0.308270676691729 17.1 17 1 increased rib number 0.000820048552187072 0.0135959261376622 1.61781107658252 0.307692307692308 17.1 17 1 small spleen 0.0003160032984397 0.00628846563895003 1.61781107658252 0.307692307692308 17.1 17 1 ventricular hypoplasia 0.0446932176749008 0.252096097429288 1.61781107658252 0.307692307692308 17.1 17 1 decreased circulating glycerol level 0.0446932176749008 0.252096097429288 1.61781107658252 0.307692307692308 17.1 17 1 abnormal erythrocyte osmotic lysis 0.0446932176749008 0.252096097429288 1.61781107658252 0.307692307692308 17.1 17 1 abnormal Mullerian duct morphology 0.0446932176749008 0.252096097429288 1.61781107658252 0.307692307692308 17.1 17 1 abnormal nerve conduction 0.0446932176749008 0.252096097429288 1.61781107658252 0.307692307692308 17.1 17 1 decreased circulating creatinine level 0.00773930853990186 0.0744740038414154 1.60955693843669 0.306122448979592 17.1 17 1 abnormal lung development 0.000562246461595396 0.00981465314539331 1.60829454083792 0.305882352941176 17.1 17 1 preweaning lethality, incomplete penetrance 1.02357593520044e-13 2.46045531147793e-11 1.60693337374486 0.305623471882641 17.1 17 1 narrow eye opening 0.0213358670049891 0.154506460480089 1.60657627743959 0.305555555555556 17.1 17 1 abnormal allantois morphology 0.0104601593780756 0.0942740813513156 1.60022617357619 0.304347826086957 17.1 17 1 embryonic lethality between implantation and placentation, complete penetrance 0.0104601593780756 0.0942740813513156 1.60022617357619 0.304347826086957 17.1 17 1 conjunctivitis 0.061971543553691 0.314921786700319 1.60022617357619 0.304347826086957 17.1 17 1 abnormal cardiovascular development 0.061971543553691 0.314921786700319 1.60022617357619 0.304347826086957 17.1 17 1 abnormal palatal shelf fusion at midline 0.061971543553691 0.314921786700319 1.60022617357619 0.304347826086957 17.1 17 1 abnormal hepatocyte physiology 0.061971543553691 0.314921786700319 1.60022617357619 0.304347826086957 17.1 17 1 abnormal hematopoietic stem cell physiology 0.061971543553691 0.314921786700319 1.60022617357619 0.304347826086957 17.1 17 1 decreased effector memory CD8-positive, alpha-beta T cell number 0.061971543553691 0.314921786700319 1.60022617357619 0.304347826086957 17.1 17 1 embryonic lethality before implantation, complete penetrance 4.03970763616295e-05 0.00120137885374113 1.59839734366353 0.304 17.1 17 1 enlarged pericardium 0.029140103421378 0.186100147010726 1.59329878754339 0.303030303030303 17.1 17 1 abnormal QRS complex 0.029140103421378 0.186100147010726 1.59329878754339 0.303030303030303 17.1 17 1 weight loss 1.57654328175815e-06 7.39934228938379e-05 1.59238833109337 0.302857142857143 17.1 17 1 preweaning lethality, complete penetrance 6.83035180683274e-23 8.49525005974822e-20 1.59157630236767 0.302702702702703 17.1 17 1 abnormal hair follicle morphology 0.00352526928976169 0.042880720578397 1.58571165045985 0.301587301587302 17.1 17 1 abnormal fertility/fecundity 0.0017875819653354 0.02491098116959 1.58456838322809 0.301369863013699 17.1 17 1 abnormal neural tube closure 0.000912914952144442 0.0149399733122322 1.58370060207626 0.301204819277108 17.1 17 1 abnormal retinal pigment epithelium morphology 0.00121720046161069 0.0187479018467901 1.57736579966796 0.3 17.1 17 1 intracranial hemorrhage 0.00472796911236342 0.051924164092733 1.57736579966796 0.3 17.1 17 1 delayed eyelid opening 0.0399271159109088 0.233966315261215 1.57736579966796 0.3 17.1 17 1 disorganized myocardium 0.0399271159109088 0.233966315261215 1.57736579966796 0.3 17.1 17 1 abnormal pericardium morphology 0.086508026221955 0.382898069799134 1.57736579966796 0.3 17.1 17 1 small gonad 0.086508026221955 0.382898069799134 1.57736579966796 0.3 17.1 17 1 absent placental labyrinth 0.086508026221955 0.382898069799134 1.57736579966796 0.3 17.1 17 1 kidney atrophy 0.086508026221955 0.382898069799134 1.57736579966796 0.3 17.1 17 1 abnormal circulating cytokine level 0.086508026221955 0.382898069799134 1.57736579966796 0.3 17.1 17 1 absent ductus venosus valve 0.086508026221955 0.382898069799134 1.57736579966796 0.3 17.1 17 1 abnormal embryonic tissue morphology 1.60933811541918e-05 0.000537346115718819 1.57378900647143 0.299319727891156 17.1 17 1 increased sensitivity to induced morbidity/mortality 1.59414170463963e-06 7.41201400054407e-05 1.5716507061909 0.298913043478261 17.1 17 1 internal hemorrhage 0.00319550014097891 0.0394594749981861 1.56951820862483 0.298507462686567 17.1 17 1 decreased white adipose tissue amount 0.00319550014097891 0.0394594749981861 1.56951820862483 0.298507462686567 17.1 17 1 incomplete embryo turning 0.00634570443219256 0.0659166822487087 1.56814143826639 0.298245614035088 17.1 17 1 increased systemic arterial blood pressure 0.0127551110193465 0.110888057509147 1.56617880818095 0.297872340425532 17.1 17 1 increased brown adipose tissue amount 0.0260956494848479 0.171472728606868 1.56315529696825 0.297297297297297 17.1 17 1 ataxia 6.96376075479613e-07 3.53517446480722e-05 1.56174831650293 0.297029702970297 17.1 17 1 decreased circulating HDL cholesterol level 7.14368968159671e-05 0.00191074495515826 1.56093490592142 0.296875 17.1 17 1 decreased eosinophil cell number 0.00427556886787105 0.0482334583166859 1.56093490592142 0.296875 17.1 17 1 increased sacral vertebrae number 0.00427556886787105 0.0482334583166859 1.56093490592142 0.296875 17.1 17 1 decreased heart weight 0.00147136833828775 0.0218721457966134 1.55789214782021 0.296296296296296 17.1 17 1 increased neuron apoptosis 0.00147136833828775 0.0218721457966134 1.55789214782021 0.296296296296296 17.1 17 1 increased cell proliferation 0.00852383530544702 0.0801627233357258 1.55789214782021 0.296296296296296 17.1 17 1 impaired limb coordination 0.00852383530544702 0.0801627233357258 1.55789214782021 0.296296296296296 17.1 17 1 abnormal cell adhesion 0.00852383530544702 0.0801627233357258 1.55789214782021 0.296296296296296 17.1 17 1 abnormal atrioventricular cushion morphology 0.0549168197952094 0.296780111078577 1.55789214782021 0.296296296296296 17.1 17 1 abnormal eye muscle morphology 0.0549168197952094 0.296780111078577 1.55789214782021 0.296296296296296 17.1 17 1 decreased circulating fructosamine level 0.0549168197952094 0.296780111078577 1.55789214782021 0.296296296296296 17.1 17 1 decreased bone ossification 0.0549168197952094 0.296780111078577 1.55789214782021 0.296296296296296 17.1 17 1 renal interstitial fibrosis 0.0172283357325032 0.130997492093343 1.55346631785481 0.295454545454545 17.1 17 1 decreased blood urea nitrogen level 0.0172283357325032 0.130997492093343 1.55346631785481 0.295454545454545 17.1 17 1 prenatal lethality, complete penetrance 1.01756715415318e-08 7.90999467486264e-07 1.5508872370836 0.294964028776978 17.1 17 1 abnormal heart morphology 1.91302177101314e-07 1.18380286323084e-05 1.54777596504215 0.294372294372294 17.1 17 1 impaired balance 0.000466573086821459 0.00850256815727751 1.546437058498 0.294117647058824 17.1 17 1 decreased susceptibility to injury 0.00385855171253904 0.0454888501655965 1.546437058498 0.294117647058824 17.1 17 1 decreased mean corpuscular hemoglobin 0.00385855171253904 0.0454888501655965 1.546437058498 0.294117647058824 17.1 17 1 abnormal response to novel object 0.011459619357816 0.102538860261034 1.546437058498 0.294117647058824 17.1 17 1 abnormal endoderm development 0.0355450499210784 0.211536906786612 1.546437058498 0.294117647058824 17.1 17 1 abnormal spleen red pulp morphology 0.0355450499210784 0.211536906786612 1.546437058498 0.294117647058824 17.1 17 1 abnormal vagus nerve morphology 0.121814225151798 0.471028092727635 1.546437058498 0.294117647058824 17.1 17 1 hyperlipidemia 0.121814225151798 0.471028092727635 1.546437058498 0.294117647058824 17.1 17 1 abnormal heart rate 0.121814225151798 0.471028092727635 1.546437058498 0.294117647058824 17.1 17 1 abnormal touch/ nociception 0.121814225151798 0.471028092727635 1.546437058498 0.294117647058824 17.1 17 1 abnormal embryonic-extraembryonic boundary morphology 0.121814225151798 0.471028092727635 1.546437058498 0.294117647058824 17.1 17 1 increased regulatory T cell number 0.121814225151798 0.471028092727635 1.546437058498 0.294117647058824 17.1 17 1 increased brain size 0.121814225151798 0.471028092727635 1.546437058498 0.294117647058824 17.1 17 1 increased circulating magnesium level 0.121814225151798 0.471028092727635 1.546437058498 0.294117647058824 17.1 17 1 abnormal ductus venosus valve morphology 0.121814225151798 0.471028092727635 1.546437058498 0.294117647058824 17.1 17 1 increased insulin sensitivity 4.05691753625147e-05 0.00120137885374113 1.54427420946513 0.293706293706294 17.1 17 1 abnormal renal glomerulus morphology 0.000319115624297342 0.00632510052143138 1.54359955930809 0.293577981651376 17.1 17 1 thick ventricular wall 0.0233048778821002 0.165159212910895 1.53889346309069 0.292682926829268 17.1 17 1 increased tumor growth/size 0.0233048778821002 0.165159212910895 1.53889346309069 0.292682926829268 17.1 17 1 abnormal intestinal epithelium morphology 0.0154212022261762 0.12287358086438 1.53355008301051 0.291666666666667 17.1 17 1 curly vibrissae 0.0758838201163244 0.355147699979975 1.53355008301051 0.291666666666667 17.1 17 1 hemolytic anemia 0.0758838201163244 0.355147699979975 1.53355008301051 0.291666666666667 17.1 17 1 small lymph nodes 0.0758838201163244 0.355147699979975 1.53355008301051 0.291666666666667 17.1 17 1 abnormal cardiac muscle contractility 0.0758838201163244 0.355147699979975 1.53355008301051 0.291666666666667 17.1 17 1 decreased ovulation rate 0.0758838201163244 0.355147699979975 1.53355008301051 0.291666666666667 17.1 17 1 increased circulating total protein level 0.0758838201163244 0.355147699979975 1.53355008301051 0.291666666666667 17.1 17 1 abnormal lung saccule morphology 0.0758838201163244 0.355147699979975 1.53355008301051 0.291666666666667 17.1 17 1 abnormal glucose homeostasis 5.70930519835508e-06 0.000221904635639192 1.53114262605131 0.291208791208791 17.1 17 1 hunched posture 0.00235261469892247 0.0309636458389929 1.53077693638663 0.291139240506329 17.1 17 1 decreased startle reflex 0.000261293204058626 0.00532759709094945 1.52793268343905 0.290598290598291 17.1 17 1 impaired glucose tolerance 1.55360436255458e-07 1.00171156216316e-05 1.52648303193673 0.290322580645161 17.1 17 1 decreased double-negative T cell number 0.0485471715239053 0.271678490811506 1.52648303193673 0.290322580645161 17.1 17 1 decreased spleen weight 0.00463191416954454 0.0511485052038868 1.52402492721542 0.289855072463768 17.1 17 1 abnormal blood vessel morphology 5.78500845970503e-05 0.00160784453000182 1.52297387554148 0.289655172413793 17.1 17 1 abnormal reproductive system physiology 0.0315769823789446 0.191720793696163 1.52201963125856 0.289473684210526 17.1 17 1 decreased total retina thickness 0.0315769823789446 0.191720793696163 1.52201963125856 0.289473684210526 17.1 17 1 increased susceptibility to parasitic infection 0.00143818775716646 0.0216162661386801 1.5189448441247 0.288888888888889 17.1 17 1 abnormal ectoderm development 0.0207737699155971 0.150875190262913 1.5189448441247 0.288888888888889 17.1 17 1 lethality at weaning, complete penetrance 0.0207737699155971 0.150875190262913 1.5189448441247 0.288888888888889 17.1 17 1 eyelids open at birth 0.0137806873498175 0.11719473429973 1.51669788429611 0.288461538461538 17.1 17 1 decreased kidney weight 0.0137806873498175 0.11719473429973 1.51669788429611 0.288461538461538 17.1 17 1 abnormal colon morphology 0.00919993786973903 0.0849159385936024 1.51498410137601 0.288135593220339 17.1 17 1 abnormal spermatogenesis 8.07979064636079e-06 0.000297755247893666 1.51449977142032 0.28804347826087 17.1 17 1 increased heart weight 0.000100202041895007 0.0024925257921383 1.51306071910595 0.287769784172662 17.1 17 1 abnormal pulmonary alveolus morphology 0.000881273816674496 0.014517672973363 1.50969003928616 0.287128712871287 17.1 17 1 abnormal embryo development 0.000131817754183539 0.0030788419110944 1.50777613203555 0.286764705882353 17.1 17 1 skin edema 0.0280156532840303 0.180461153515827 1.50225314254091 0.285714285714286 17.1 17 1 abnormal hippocampus pyramidal cell morphology 0.0428649909377899 0.245118770017821 1.50225314254091 0.285714285714286 17.1 17 1 abnormal stria vascularis morphology 0.0665146680346724 0.325502985573814 1.50225314254091 0.285714285714286 17.1 17 1 rib bifurcation 0.0665146680346724 0.325502985573814 1.50225314254091 0.285714285714286 17.1 17 1 shortened head 0.0665146680346724 0.325502985573814 1.50225314254091 0.285714285714286 17.1 17 1 small superior cervical ganglion 0.0665146680346724 0.325502985573814 1.50225314254091 0.285714285714286 17.1 17 1 abnormal ovulation 0.0665146680346724 0.325502985573814 1.50225314254091 0.285714285714286 17.1 17 1 abnormal respiration 0.0665146680346724 0.325502985573814 1.50225314254091 0.285714285714286 17.1 17 1 premature aging 0.0665146680346724 0.325502985573814 1.50225314254091 0.285714285714286 17.1 17 1 abnormal hormone level 0.0665146680346724 0.325502985573814 1.50225314254091 0.285714285714286 17.1 17 1 corneal vascularization 0.0665146680346724 0.325502985573814 1.50225314254091 0.285714285714286 17.1 17 1 abnormal eye pigmentation 0.105454018951898 0.45383541893226 1.50225314254091 0.285714285714286 17.1 17 1 increased incidence of induced tumors 0.105454018951898 0.45383541893226 1.50225314254091 0.285714285714286 17.1 17 1 embryonic lethality at implantation, complete penetrance 0.105454018951898 0.45383541893226 1.50225314254091 0.285714285714286 17.1 17 1 abnormal extraembryonic tissue morphology 0.00104601794223255 0.0164894433122872 1.49488915654806 0.284313725490196 17.1 17 1 alopecia 0.0015371850229433 0.0226928649529463 1.49434654705385 0.284210526315789 17.1 17 1 small seminiferous tubules 0.00494790607819124 0.0535126798673944 1.49210278346969 0.283783783783784 17.1 17 1 absent mesoderm 0.0109679255180038 0.098316089102827 1.48973436635307 0.283333333333333 17.1 17 1 abnormal long bone epiphyseal plate morphology 0.0109679255180038 0.098316089102827 1.48973436635307 0.283333333333333 17.1 17 1 muscular ventricular septal defect 0.0109679255180038 0.098316089102827 1.48973436635307 0.283333333333333 17.1 17 1 azoospermia 5.96970189535583e-05 0.00164995927385529 1.48808094308298 0.283018867924528 17.1 17 1 prenatal lethality, incomplete penetrance 3.7997424517321e-08 2.73966937643003e-06 1.48742827600268 0.282894736842105 17.1 17 1 postnatal growth retardation 7.07014470490135e-15 1.95410943927135e-12 1.48629783955641 0.282679738562091 17.1 17 1 abnormal sleep pattern 0.0248367074000752 0.171472728606868 1.48592430403503 0.282608695652174 17.1 17 1 premature death 2.87190783315534e-20 2.3812902449913e-17 1.48393298226602 0.282229965156794 17.1 17 1 decreased liver weight 0.00656362776613094 0.0667034558293037 1.48109464757555 0.28169014084507 17.1 17 1 scoliosis 0.0583103032226737 0.307628588051752 1.47878043718871 0.28125 17.1 17 1 increased dopamine level 0.0583103032226737 0.307628588051752 1.47878043718871 0.28125 17.1 17 1 neonatal lethality 0.0583103032226737 0.307628588051752 1.47878043718871 0.28125 17.1 17 1 abnormal heart atrium morphology 0.0583103032226737 0.307628588051752 1.47878043718871 0.28125 17.1 17 1 abnormal depression-related behavior 0.0583103032226737 0.307628588051752 1.47878043718871 0.28125 17.1 17 1 abnormal auditory brainstem response waveform shape 0.0583103032226737 0.307628588051752 1.47878043718871 0.28125 17.1 17 1 decreased body length 2.55016421157293e-07 1.52856228344281e-05 1.47758110187874 0.281021897810219 17.1 17 1 reduced fertility 0.000217422378337351 0.00456403515708152 1.47523420112831 0.280575539568345 17.1 17 1 abnormal liver physiology 0.00162805459187954 0.0233560465927119 1.47220807969009 0.28 17.1 17 1 abnormal inner ear vestibule morphology 0.0914710417549936 0.402715427195658 1.47220807969009 0.28 17.1 17 1 abnormal thyroid gland morphology 0.0914710417549936 0.402715427195658 1.47220807969009 0.28 17.1 17 1 spontaneous skin ulceration 0.0914710417549936 0.402715427195658 1.47220807969009 0.28 17.1 17 1 pericardial edema 0.00870545273889563 0.0813262180061233 1.4691152055731 0.279411764705882 17.1 17 1 abnormal organ of Corti morphology 0.0333791026527164 0.200314880213829 1.46731702294694 0.27906976744186 17.1 17 1 abnormal intestinal mucosa morphology 0.0333791026527164 0.200314880213829 1.46731702294694 0.27906976744186 17.1 17 1 kidney failure 0.0333791026527164 0.200314880213829 1.46731702294694 0.27906976744186 17.1 17 1 decreased bone mineral content 9.2994618794455e-06 0.00033284045216001 1.46614128815291 0.278846153846154 17.1 17 1 decreased total body fat amount 2.51928976807149e-08 1.84315685237583e-06 1.46402214939242 0.278443113772455 17.1 17 1 decreased bone mineral density 6.59988833664642e-07 3.38499427575422e-05 1.46272016510562 0.278195488721804 17.1 17 1 reduced long term depression 0.0511454232196362 0.283666087533657 1.46052388858144 0.277777777777778 17.1 17 1 abnormal retinal blood vessel morphology 0.0511454232196362 0.283666087533657 1.46052388858144 0.277777777777778 17.1 17 1 abnormal phrenic nerve morphology 0.147600790460178 0.508160024398681 1.46052388858144 0.277777777777778 17.1 17 1 thick dermal layer 0.147600790460178 0.508160024398681 1.46052388858144 0.277777777777778 17.1 17 1 abnormal iron level 0.147600790460178 0.508160024398681 1.46052388858144 0.277777777777778 17.1 17 1 abnormal thymus cortex morphology 0.147600790460178 0.508160024398681 1.46052388858144 0.277777777777778 17.1 17 1 absent allantois 0.147600790460178 0.508160024398681 1.46052388858144 0.277777777777778 17.1 17 1 increased circulating renin level 0.147600790460178 0.508160024398681 1.46052388858144 0.277777777777778 17.1 17 1 increased circulating glycerol level 0.147600790460178 0.508160024398681 1.46052388858144 0.277777777777778 17.1 17 1 decreased activity of thyroid 0.147600790460178 0.508160024398681 1.46052388858144 0.277777777777778 17.1 17 1 increased susceptibility to autoimmune disorder 0.147600790460178 0.508160024398681 1.46052388858144 0.277777777777778 17.1 17 1 abnormal sperm axoneme morphology 0.147600790460178 0.508160024398681 1.46052388858144 0.277777777777778 17.1 17 1 abnormal aerobic respiration 0.147600790460178 0.508160024398681 1.46052388858144 0.277777777777778 17.1 17 1 abnormal chondrocyte morphology 0.0194984718581409 0.145216912416543 1.46052388858144 0.277777777777778 17.1 17 1 abnormal osteoblast physiology 0.0194984718581409 0.145216912416543 1.46052388858144 0.277777777777778 17.1 17 1 enlarged heart 4.88953146640545e-06 0.000193058881312437 1.4504513100395 0.275862068965517 17.1 17 1 cochlear ganglion degeneration 0.0172732371483886 0.130997492093343 1.4504513100395 0.275862068965517 17.1 17 1 glomerulosclerosis 0.0172732371483886 0.130997492093343 1.4504513100395 0.275862068965517 17.1 17 1 lordosis 0.0795089844301025 0.36864603684973 1.4504513100395 0.275862068965517 17.1 17 1 abnormal circulating glucose level 0.0795089844301025 0.36864603684973 1.4504513100395 0.275862068965517 17.1 17 1 stomach inflammation 0.0795089844301025 0.36864603684973 1.4504513100395 0.275862068965517 17.1 17 1 polychromatophilia 0.0795089844301025 0.36864603684973 1.4504513100395 0.275862068965517 17.1 17 1 abnormal epidermal layer morphology 0.0102533973952491 0.0931037132786891 1.44782368085465 0.27536231884058 17.1 17 1 decreased circulating phosphate level 0.0448929762018688 0.252649950909839 1.44591864969563 0.275 17.1 17 1 abnormal skin pigmentation 0.0448929762018688 0.252649950909839 1.44591864969563 0.275 17.1 17 1 increased lung adenocarcinoma incidence 0.0260003140301051 0.171472728606868 1.44334125459813 0.274509803921569 17.1 17 1 abnormal dendritic spine morphology 0.0260003140301051 0.171472728606868 1.44334125459813 0.274509803921569 17.1 17 1 increased food intake 0.00546390730765386 0.0579593579010191 1.43965926160171 0.273809523809524 17.1 17 1 abnormal locomotor coordination 0.0692491281481597 0.329049104619957 1.43396890878905 0.272727272727273 17.1 17 1 increased sensitivity to xenobiotic induced morbidity/mortality 0.00178515951798702 0.02491098116959 1.43396890878905 0.272727272727273 17.1 17 1 abnormal suckling behavior 0.00486166741872211 0.0526945433728594 1.43396890878905 0.272727272727273 17.1 17 1 small kidney 0.00486166741872211 0.0526945433728594 1.43396890878905 0.272727272727273 17.1 17 1 abnormal rostral-caudal axis patterning 0.0229570862828074 0.163159291795667 1.43396890878905 0.272727272727273 17.1 17 1 osteoporosis 0.0394356402477963 0.231632007358662 1.43396890878905 0.272727272727273 17.1 17 1 abnormal circadian rhythm 0.0394356402477963 0.231632007358662 1.43396890878905 0.272727272727273 17.1 17 1 embryonic lethality, incomplete penetrance 0.0394356402477963 0.231632007358662 1.43396890878905 0.272727272727273 17.1 17 1 abnormal abdominal fat pad morphology 0.126348929171316 0.481306219469599 1.43396890878905 0.272727272727273 17.1 17 1 abnormal facial nerve morphology 0.126348929171316 0.481306219469599 1.43396890878905 0.272727272727273 17.1 17 1 intracerebral hemorrhage 0.126348929171316 0.481306219469599 1.43396890878905 0.272727272727273 17.1 17 1 parakeratosis 0.126348929171316 0.481306219469599 1.43396890878905 0.272727272727273 17.1 17 1 abnormal retinal layer morphology 0.126348929171316 0.481306219469599 1.43396890878905 0.272727272727273 17.1 17 1 abnormal limb posture 0.126348929171316 0.481306219469599 1.43396890878905 0.272727272727273 17.1 17 1 abnormal basement membrane morphology 0.126348929171316 0.481306219469599 1.43396890878905 0.272727272727273 17.1 17 1 decreased circulating estradiol level 0.126348929171316 0.481306219469599 1.43396890878905 0.272727272727273 17.1 17 1 embryonic lethality before implantation, incomplete penetrance 0.126348929171316 0.481306219469599 1.43396890878905 0.272727272727273 17.1 17 1 male infertility 7.6515798987405e-11 9.0634785705319e-09 1.43206835357528 0.272365805168986 17.1 17 1 small heart 0.0346691186844771 0.207486566426938 1.42401079136691 0.270833333333333 17.1 17 1 thymus atrophy 0.0346691186844771 0.207486566426938 1.42401079136691 0.270833333333333 17.1 17 1 cardiac fibrosis 0.00638070606509526 0.0659166822487087 1.42272209381816 0.270588235294118 17.1 17 1 increased white adipose tissue amount 0.0604231171954836 0.313628099230602 1.42105026997113 0.27027027027027 17.1 17 1 malocclusion 0.0604231171954836 0.313628099230602 1.42105026997113 0.27027027027027 17.1 17 1 abnormal long bone metaphysis morphology 0.0604231171954836 0.313628099230602 1.42105026997113 0.27027027027027 17.1 17 1 increased erythroid progenitor cell number 0.0604231171954836 0.313628099230602 1.42105026997113 0.27027027027027 17.1 17 1 abnormal chromosome morphology 0.0604231171954836 0.313628099230602 1.42105026997113 0.27027027027027 17.1 17 1 abnormal respiratory electron transport chain 0.0604231171954836 0.313628099230602 1.42105026997113 0.27027027027027 17.1 17 1 perinatal lethality, incomplete penetrance 1.67231722968419e-05 0.000554651881178589 1.41916392005524 0.269911504424779 17.1 17 1 embryonic lethality during organogenesis, incomplete penetrance 1.49665802680078e-05 0.000506522019274412 1.41734318231034 0.269565217391304 17.1 17 1 hydroencephaly 0.00185159968076865 0.0255255762968179 1.41734318231034 0.269565217391304 17.1 17 1 increased susceptibility to injury 0.0305022817544215 0.191720793696163 1.41558469200971 0.269230769230769 17.1 17 1 abnormal female meiosis 0.0305022817544215 0.191720793696163 1.41558469200971 0.269230769230769 17.1 17 1 abnormal kidney cortex morphology 0.108704976942396 0.465811593702344 1.41558469200971 0.269230769230769 17.1 17 1 decreased bone resorption 0.108704976942396 0.465811593702344 1.41558469200971 0.269230769230769 17.1 17 1 abnormal trabecular bone morphology 0.00164948307779129 0.0233794253903467 1.41388531062674 0.26890756302521 17.1 17 1 decreased compact bone thickness 0.0158375490532392 0.124081585102149 1.41256638776235 0.26865671641791 17.1 17 1 decreased body size 2.27833787826125e-15 7.08420684021858e-13 1.41000952852524 0.268170426065163 17.1 17 1 abnormal skeletal muscle fiber morphology 0.0140048083461667 0.118281281176919 1.40703991519677 0.267605633802817 17.1 17 1 increased oxygen consumption 0.00742033829377346 0.0722594637226333 1.40617881365748 0.267441860465116 17.1 17 1 abnormal hair cycle 0.0939023911643545 0.412325150964398 1.40210293303818 0.266666666666667 17.1 17 1 increased bone mineral density 0.00279072710167207 0.0356935403242385 1.39589893775925 0.265486725663717 17.1 17 1 organ of Corti degeneration 0.0405101483175127 0.236824897625882 1.39494934664513 0.26530612244898 17.1 17 1 increased fluid intake 0.0405101483175127 0.236824897625882 1.39494934664513 0.26530612244898 17.1 17 1 decreased circulating glucose level 4.51938263637414e-06 0.00018132200496743 1.39456474522615 0.265232974910394 17.1 17 1 abnormal lipid level 0.00970525080383179 0.088920115559969 1.39365652982711 0.265060240963855 17.1 17 1 short maxilla 0.0813825963099092 0.374540625940609 1.3917933526482 0.264705882352941 17.1 17 1 increased width of hypertrophic chondrocyte zone 0.0813825963099092 0.374540625940609 1.3917933526482 0.264705882352941 17.1 17 1 abnormal nervous system development 0.0813825963099092 0.374540625940609 1.3917933526482 0.264705882352941 17.1 17 1 abnormal direction of heart looping 0.0813825963099092 0.374540625940609 1.3917933526482 0.264705882352941 17.1 17 1 abnormal skin physiology 0.0813825963099092 0.374540625940609 1.3917933526482 0.264705882352941 17.1 17 1 no abnormal phenotype detected 1.91934105068463e-30 9.54872172715601e-27 1.3909911662778 0.264553314121037 17.1 17 1 abnormal pancreatic islet morphology 0.0355467043364035 0.211536906786612 1.38887554687745 0.264150943396226 17.1 17 1 cochlear outer hair cell degeneration 0.0162467275121999 0.127087215995589 1.38749769415237 0.263888888888889 17.1 17 1 increased thermal nociceptive threshold 0.00761333598190272 0.0734037723061357 1.3866952084993 0.263736263736264 17.1 17 1 increased grip strength 0.00761333598190272 0.0734037723061357 1.3866952084993 0.263736263736264 17.1 17 1 decreased body weight 1.91937510158217e-21 1.90977822607426e-18 1.38454833250338 0.263327948303716 17.1 17 1 increased bone marrow cell number 0.0707253082013907 0.334148535899258 1.38365421023505 0.263157894736842 17.1 17 1 flaky skin 0.175459042310764 0.534543010101683 1.38365421023505 0.263157894736842 17.1 17 1 stereotypic behavior 0.175459042310764 0.534543010101683 1.38365421023505 0.263157894736842 17.1 17 1 unresponsive to tactile stimuli 0.175459042310764 0.534543010101683 1.38365421023505 0.263157894736842 17.1 17 1 delayed sexual maturation 0.175459042310764 0.534543010101683 1.38365421023505 0.263157894736842 17.1 17 1 increased malignant tumor incidence 0.175459042310764 0.534543010101683 1.38365421023505 0.263157894736842 17.1 17 1 decreased germ cell number 0.175459042310764 0.534543010101683 1.38365421023505 0.263157894736842 17.1 17 1 increased liver adenoma incidence 0.175459042310764 0.534543010101683 1.38365421023505 0.263157894736842 17.1 17 1 absent amnion 0.175459042310764 0.534543010101683 1.38365421023505 0.263157894736842 17.1 17 1 decreased liver regeneration 0.175459042310764 0.534543010101683 1.38365421023505 0.263157894736842 17.1 17 1 Leydig cell hypoplasia 0.175459042310764 0.534543010101683 1.38365421023505 0.263157894736842 17.1 17 1 increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 0.175459042310764 0.534543010101683 1.38365421023505 0.263157894736842 17.1 17 1 embryonic lethality between implantation and somite formation, incomplete penetrance 0.175459042310764 0.534543010101683 1.38365421023505 0.263157894736842 17.1 17 1 perinatal lethality, complete penetrance 7.92243661909432e-05 0.00206356660628242 1.38235500440384 0.262910798122066 17.1 17 1 abnormal vibrissa morphology 0.0616061138218903 0.314921786700319 1.3770653806625 0.261904761904762 17.1 17 1 teratozoospermia 0.00991533090136586 0.0906778882983367 1.37422020425618 0.261363636363636 17.1 17 1 abnormal enzyme/coenzyme activity 0.00076986454752676 0.0128526044427706 1.3730785092651 0.261146496815287 17.1 17 1 atrial septal defect 0.053769445801336 0.296780111078577 1.37162243449388 0.260869565217391 17.1 17 1 abnormal circulating insulin level 0.149070359389301 0.508160024398681 1.37162243449388 0.260869565217391 17.1 17 1 hypotension 0.149070359389301 0.508160024398681 1.37162243449388 0.260869565217391 17.1 17 1 abnormal cochlear ganglion morphology 0.149070359389301 0.508160024398681 1.37162243449388 0.260869565217391 17.1 17 1 abnormal sternum morphology 0.021282176549163 0.154342315352895 1.37162243449388 0.260869565217391 17.1 17 1 retinal degeneration 0.00776662089534503 0.0745925462439026 1.3692411455451 0.260416666666667 17.1 17 1 abnormal seminiferous tubule morphology 0.00125273422994983 0.0192356567716061 1.36849087642426 0.26027397260274 17.1 17 1 decreased percent body fat/body weight 0.0187589414739017 0.141918226268026 1.36849087642426 0.26027397260274 17.1 17 1 abnormal digestive system physiology 0.0470106393418413 0.263672977142796 1.36705035971223 0.26 17.1 17 1 abnormal circulating protein level 0.0470106393418413 0.263672977142796 1.36705035971223 0.26 17.1 17 1 abnormal neural tube morphology 0.000784253341102946 0.0130490313444386 1.36315562934268 0.259259259259259 17.1 17 1 increased exploration in new environment 0.0146036822776278 0.120088131125948 1.36315562934268 0.259259259259259 17.1 17 1 abnormal mandible morphology 0.0411635857037954 0.239799577138621 1.36315562934268 0.259259259259259 17.1 17 1 abnormal small intestine morphology 0.0411635857037954 0.239799577138621 1.36315562934268 0.259259259259259 17.1 17 1 abnormal trigeminal nerve morphology 0.127530831943912 0.485065664312661 1.36315562934268 0.259259259259259 17.1 17 1 abnormal skin appearance 0.127530831943912 0.485065664312661 1.36315562934268 0.259259259259259 17.1 17 1 increased tumor incidence 0.00333922128751005 0.0410188293959568 1.35687380616599 0.258064516129032 17.1 17 1 abnormal eyelid morphology 0.109678119734945 0.467966248440269 1.35687380616599 0.258064516129032 17.1 17 1 decreased neuronal precursor cell number 0.109678119734945 0.467966248440269 1.35687380616599 0.258064516129032 17.1 17 1 abnormal podocyte morphology 0.109678119734945 0.467966248440269 1.35687380616599 0.258064516129032 17.1 17 1 small cranium 0.109678119734945 0.467966248440269 1.35687380616599 0.258064516129032 17.1 17 1 abnormal artery morphology 0.0947156135541041 0.415163151922175 1.35202782828682 0.257142857142857 17.1 17 1 decreased bone volume 0.0947156135541041 0.415163151922175 1.35202782828682 0.257142857142857 17.1 17 1 postnatal lethality, incomplete penetrance 1.49746580919045e-09 1.43267161552355e-07 1.35149886591269 0.257042253521127 17.1 17 1 increased urine protein level 0.018997354916113 0.142551795939158 1.3481758971521 0.256410256410256 17.1 17 1 absent gastric milk in neonates 0.018997354916113 0.142551795939158 1.3481758971521 0.256410256410256 17.1 17 1 abnormal circulating hormone level 0.0820691098099701 0.376307669405162 1.3481758971521 0.256410256410256 17.1 17 1 increased circulating creatinine level 0.0147792649763485 0.121154119704157 1.34504060436803 0.255813953488372 17.1 17 1 abnormal male reproductive system morphology 0.0713091489112938 0.336268261453732 1.34504060436803 0.255813953488372 17.1 17 1 abnormal axon guidance 0.0713091489112938 0.336268261453732 1.34504060436803 0.255813953488372 17.1 17 1 abnormal behavior 2.74242507865156e-05 0.000858085834357957 1.34284138820653 0.255395683453237 17.1 17 1 increased respiratory quotient 0.0621054359125299 0.314958760106867 1.34243897844082 0.25531914893617 17.1 17 1 kinked tail 0.0090079209040307 0.0832981533411761 1.34024545069827 0.254901960784314 17.1 17 1 distended abdomen 0.0541983822116457 0.296780111078577 1.34024545069827 0.254901960784314 17.1 17 1 small lung 0.0541983822116457 0.296780111078577 1.34024545069827 0.254901960784314 17.1 17 1 increased circulating calcium level 0.0473804391646205 0.265447843292778 1.33837098153645 0.254545454545455 17.1 17 1 reduced female fertility 0.000140696937774672 0.0032405891918009 1.33713480144267 0.254310344827586 17.1 17 1 neonatal lethality, incomplete penetrance 6.26710085815941e-05 0.0017131223499639 1.33469413818058 0.253846153846154 17.1 17 1 increased circulating free fatty acid level 0.0280517618030839 0.180461153515827 1.33298518281799 0.253521126760563 17.1 17 1 abnormal visceral yolk sac morphology 0.0217207621607496 0.15657597162497 1.33111037946663 0.253164556962025 17.1 17 1 abnormal motor coordination/ balance 0.0116083772324973 0.103497628551387 1.32774898961949 0.252525252525253 17.1 17 1 abnormal eye morphology 0.00343797856988894 0.0420908863092393 1.32392812921771 0.251798561151079 17.1 17 1 abnormal spatial learning 0.00168107631110916 0.0237595302493411 1.32253574205289 0.251533742331288 17.1 17 1 postnatal lethality, complete penetrance 2.27840373748804e-06 0.000103991363247734 1.32128223288249 0.251295336787565 17.1 17 1 abnormal forebrain development 0.0319867732333784 0.193358683883424 1.3144714997233 0.25 17.1 17 1 apnea 0.173465872480293 0.532982843163485 1.3144714997233 0.25 17.1 17 1 prolonged QT interval 0.173465872480293 0.532982843163485 1.3144714997233 0.25 17.1 17 1 increased hemangiosarcoma incidence 0.173465872480293 0.532982843163485 1.3144714997233 0.25 17.1 17 1 decreased heart rate 0.0131852676524341 0.112903109416282 1.3144714997233 0.25 17.1 17 1 hyperglycemia 0.019191655610057 0.143576671669223 1.3144714997233 0.25 17.1 17 1 increased liver weight 0.019191655610057 0.143576671669223 1.3144714997233 0.25 17.1 17 1 hydronephrosis 0.0217790095204983 0.15657597162497 1.3144714997233 0.25 17.1 17 1 abnormal hair growth 0.0620970823640538 0.314958760106867 1.3144714997233 0.25 17.1 17 1 muscular atrophy 0.0819336517991263 0.376118494912719 1.3144714997233 0.25 17.1 17 1 abnormal somite shape 0.147869553246991 0.508160024398681 1.3144714997233 0.25 17.1 17 1 absent corpus callosum 0.147869553246991 0.508160024398681 1.3144714997233 0.25 17.1 17 1 waved hair 0.205109381007033 0.587832335859903 1.3144714997233 0.25 17.1 17 1 abnormal circulating enzyme level 0.205109381007033 0.587832335859903 1.3144714997233 0.25 17.1 17 1 brain inflammation 0.205109381007033 0.587832335859903 1.3144714997233 0.25 17.1 17 1 abnormal dopamine level 0.205109381007033 0.587832335859903 1.3144714997233 0.25 17.1 17 1 abnormal hyoid bone morphology 0.205109381007033 0.587832335859903 1.3144714997233 0.25 17.1 17 1 abnormal lens epithelium morphology 0.205109381007033 0.587832335859903 1.3144714997233 0.25 17.1 17 1 spleen atrophy 0.205109381007033 0.587832335859903 1.3144714997233 0.25 17.1 17 1 abnormal male reproductive system physiology 0.205109381007033 0.587832335859903 1.3144714997233 0.25 17.1 17 1 abnormal optic stalk morphology 0.205109381007033 0.587832335859903 1.3144714997233 0.25 17.1 17 1 dilated vasculature 0.205109381007033 0.587832335859903 1.3144714997233 0.25 17.1 17 1 abnormal response to tactile stimuli 0.205109381007033 0.587832335859903 1.3144714997233 0.25 17.1 17 1 decreased muscle cell glucose uptake 0.205109381007033 0.587832335859903 1.3144714997233 0.25 17.1 17 1 embryonic growth arrest 0.000327197256415931 0.00640868641995771 1.30873144950617 0.248908296943231 17.1 17 1 cataract 0.00806142224312612 0.0765373581289169 1.30360809889914 0.247933884297521 17.1 17 1 anophthalmia 0.0217515885112957 0.15657597162497 1.29970215702978 0.247191011235955 17.1 17 1 abnormal skeleton development 0.028055887091769 0.180461153515827 1.29824345651684 0.246913580246914 17.1 17 1 perimembraneous ventricular septal defect 0.0413820841701875 0.240542666167392 1.29542118813311 0.246376811594203 17.1 17 1 decreased circulating cholesterol level 0.0016913879553578 0.023837549795765 1.29292278661308 0.245901639344262 17.1 17 1 neonatal lethality, complete penetrance 1.30840171597972e-06 6.38166523235208e-05 1.29141059621938 0.245614035087719 17.1 17 1 increased hepatocellular carcinoma incidence 0.061709206703373 0.314921786700319 1.29141059621938 0.245614035087719 17.1 17 1 abnormal circulating amino acid level 0.061709206703373 0.314921786700319 1.29141059621938 0.245614035087719 17.1 17 1 respiratory failure 0.00438324701251515 0.0492249523414511 1.28835617191423 0.245033112582781 17.1 17 1 improved glucose tolerance 0.00133252007138992 0.0203978072466611 1.28764555074935 0.244897959183673 17.1 17 1 abnormal epidermis stratum corneum morphology 0.0812208403953696 0.374540625940609 1.28764555074935 0.244897959183673 17.1 17 1 decreased osteoclast cell number 0.0934874943207683 0.410865975482175 1.28526102195167 0.244444444444444 17.1 17 1 female infertility 0.000230130162865884 0.00481049395066291 1.28482176664683 0.244360902255639 17.1 17 1 abnormal developmental patterning 0.0317027803772133 0.191875100214886 1.28241121924224 0.24390243902439 17.1 17 1 scaly skin 0.10789745824715 0.463149141311107 1.28241121924224 0.24390243902439 17.1 17 1 abnormal cornea morphology 0.0360607465492064 0.213828622267345 1.2807671022945 0.243589743589744 17.1 17 1 increased embryonic tissue cell apoptosis 0.0360607465492064 0.213828622267345 1.2807671022945 0.243589743589744 17.1 17 1 abnormal intestine morphology 0.0410584496041332 0.239748576033524 1.27894524297402 0.243243243243243 17.1 17 1 abnormal hair follicle development 0.124929833126224 0.479202713803365 1.27894524297402 0.243243243243243 17.1 17 1 abnormal calcium ion homeostasis 0.124929833126224 0.479202713803365 1.27894524297402 0.243243243243243 17.1 17 1 abnormal retina morphology 0.00117454988097918 0.0181471604281721 1.27691517115978 0.242857142857143 17.1 17 1 impaired fertilization 0.0468001194757709 0.263085417392046 1.27691517115978 0.242857142857143 17.1 17 1 abnormal epidermis stratum basale morphology 0.145217236308117 0.508160024398681 1.27463903003471 0.242424242424242 17.1 17 1 abnormal retinal pigmentation 0.031404194764735 0.191720793696163 1.26914489628456 0.241379310344828 17.1 17 1 focal hair loss 0.169620643325093 0.528074280689822 1.26914489628456 0.241379310344828 17.1 17 1 short sternum 0.169620643325093 0.528074280689822 1.26914489628456 0.241379310344828 17.1 17 1 increased circulating triglyceride level 0.00700661167066219 0.0708493761413504 1.26914489628456 0.241379310344828 17.1 17 1 diluted coat color 0.0800993894608494 0.370692523318815 1.26578737010392 0.240740740740741 17.1 17 1 enlarged liver 0.0241143025104851 0.169447252810259 1.26189263973437 0.24 17.1 17 1 ruffled hair 0.199358976919862 0.579667393440276 1.26189263973437 0.24 17.1 17 1 mandible hypoplasia 0.199358976919862 0.579667393440276 1.26189263973437 0.24 17.1 17 1 increased cellular sensitivity to ionizing radiation 0.199358976919862 0.579667393440276 1.26189263973437 0.24 17.1 17 1 abnormal stomach mucosa morphology 0.199358976919862 0.579667393440276 1.26189263973437 0.24 17.1 17 1 delayed wound healing 0.105970309569733 0.455269680578084 1.25732056495272 0.239130434782609 17.1 17 1 small testis 0.000394321773565935 0.00740283329619067 1.25732056495272 0.239130434782609 17.1 17 1 increased circulating cholesterol level 0.00422116379760375 0.0479458673357961 1.25472279519042 0.238636363636364 17.1 17 1 increased circulating HDL cholesterol level 0.0238094293202114 0.167778910577977 1.25187761878409 0.238095238095238 17.1 17 1 abnormal cartilage morphology 0.122363503380044 0.471028092727635 1.25187761878409 0.238095238095238 17.1 17 1 abnormal reproductive system morphology 0.122363503380044 0.471028092727635 1.25187761878409 0.238095238095238 17.1 17 1 abnormal scapula morphology 0.236251681649263 0.660645864566509 1.25187761878409 0.238095238095238 17.1 17 1 dry skin 0.236251681649263 0.660645864566509 1.25187761878409 0.238095238095238 17.1 17 1 complete atrioventricular septal defect 0.236251681649263 0.660645864566509 1.25187761878409 0.238095238095238 17.1 17 1 absent segment of posterior cerebral artery 0.236251681649263 0.660645864566509 1.25187761878409 0.238095238095238 17.1 17 1 decreased vocalization 0.236251681649263 0.660645864566509 1.25187761878409 0.238095238095238 17.1 17 1 decreased grip strength 0.00179425823501818 0.0249341751933393 1.24844781708879 0.237442922374429 17.1 17 1 abnormal frontal bone morphology 0.141751927068413 0.508160024398681 1.24528878921155 0.236842105263158 17.1 17 1 incomplete somite formation 0.141751927068413 0.508160024398681 1.24528878921155 0.236842105263158 17.1 17 1 hypoglycemia 0.0346992609582336 0.207486566426938 1.24380098898549 0.236559139784946 17.1 17 1 abnormal muscle physiology 0.0393950755107146 0.231632007358662 1.2406247862557 0.235955056179775 17.1 17 1 abnormal cervical vertebrae morphology 0.103662732417325 0.447675428625165 1.2371496467984 0.235294117647059 17.1 17 1 abnormal oocyte morphology 0.164858663999872 0.514337208386814 1.2371496467984 0.235294117647059 17.1 17 1 decreased osteoblast cell number 0.164858663999872 0.514337208386814 1.2371496467984 0.235294117647059 17.1 17 1 insulin resistance 0.0157426462714069 0.123727749131515 1.23480656034613 0.234848484848485 17.1 17 1 increased blood urea nitrogen level 0.0121704732608104 0.106598775479809 1.23288361353358 0.23448275862069 17.1 17 1 abnormal kidney morphology 0.0065060140352809 0.0664628743850564 1.23184757688355 0.234285714285714 17.1 17 1 impaired coordination 0.000197076150159197 0.00424438894823379 1.23089238702413 0.234104046242775 17.1 17 1 pulmonary hypoplasia 0.119373465409434 0.471028092727635 1.23056906357075 0.234042553191489 17.1 17 1 infertility 0.0295595324840192 0.188536761676917 1.22847803712458 0.233644859813084 17.1 17 1 hypoactivity 0.000120001264702942 0.00287022255719777 1.22730495464881 0.23342175066313 17.1 17 1 decreased insulin secretion 0.0439078296947655 0.249078053285585 1.22684006640841 0.233333333333333 17.1 17 1 abnormal kidney development 0.0882038628770405 0.38936487827265 1.22684006640841 0.233333333333333 17.1 17 1 epidermal hyperplasia 0.0882038628770405 0.38936487827265 1.22684006640841 0.233333333333333 17.1 17 1 abnormal incisor morphology 0.0882038628770405 0.38936487827265 1.22684006640841 0.233333333333333 17.1 17 1 abnormal response to new environment 0.192665328765317 0.563166868747035 1.22684006640841 0.233333333333333 17.1 17 1 abnormal estrous cycle 0.192665328765317 0.563166868747035 1.22684006640841 0.233333333333333 17.1 17 1 abnormal pain threshold 0.192665328765317 0.563166868747035 1.22684006640841 0.233333333333333 17.1 17 1 abnormal synaptic transmission 0.192665328765317 0.563166868747035 1.22684006640841 0.233333333333333 17.1 17 1 abnormal cellular respiration 0.192665328765317 0.563166868747035 1.22684006640841 0.233333333333333 17.1 17 1 abnormal left-right axis patterning 0.137834519885726 0.508160024398681 1.22276418578911 0.232558139534884 17.1 17 1 abnormal blood circulation 0.137834519885726 0.508160024398681 1.22276418578911 0.232558139534884 17.1 17 1 increased total body fat amount 0.0193368570645608 0.144445741585871 1.21637661168425 0.23134328358209 17.1 17 1 limb grasping 0.0078069041700924 0.0748349677190938 1.21335830743689 0.230769230769231 17.1 17 1 abnormal snout morphology 0.116132427433306 0.471028092727635 1.21335830743689 0.230769230769231 17.1 17 1 decreased body temperature 0.116132427433306 0.471028092727635 1.21335830743689 0.230769230769231 17.1 17 1 increased vascular permeability 0.159656772245947 0.508160024398681 1.21335830743689 0.230769230769231 17.1 17 1 failure of heart looping 0.159656772245947 0.508160024398681 1.21335830743689 0.230769230769231 17.1 17 1 abnormal stomach morphology 0.226555176913101 0.638228768483963 1.21335830743689 0.230769230769231 17.1 17 1 small seminal vesicle 0.226555176913101 0.638228768483963 1.21335830743689 0.230769230769231 17.1 17 1 abnormal ocular fundus morphology 0.226555176913101 0.638228768483963 1.21335830743689 0.230769230769231 17.1 17 1 kidney cysts 0.0734693834432867 0.346127066884802 1.20789272947546 0.22972972972973 17.1 17 1 abnormal long bone morphology 0.0984116247459421 0.426107774683257 1.20672793417221 0.229508196721311 17.1 17 1 abnormal male meiosis 0.0984116247459421 0.426107774683257 1.20672793417221 0.229508196721311 17.1 17 1 abnormal vertebrae morphology 0.03630886752176 0.215043590381853 1.20593715570945 0.229357798165138 17.1 17 1 cyanosis 0.00750341150997008 0.0726254324165392 1.20493220807969 0.229166666666667 17.1 17 1 abnormal hair shaft morphology 0.133680181480508 0.506904651574335 1.20493220807969 0.229166666666667 17.1 17 1 cleft palate 0.0240911234227306 0.169447252810259 1.20409603028088 0.229007633587786 17.1 17 1 abnormal intestinal goblet cell morphology 0.185641790057878 0.544556548076617 1.20180251403273 0.228571428571429 17.1 17 1 impaired adaptive thermogenesis 0.185641790057878 0.544556548076617 1.20180251403273 0.228571428571429 17.1 17 1 decreased bone mineralization 0.185641790057878 0.544556548076617 1.20180251403273 0.228571428571429 17.1 17 1 increased circulating alkaline phosphatase level 0.0140211975064146 0.118281281176919 1.20087519727807 0.228395061728395 17.1 17 1 abnormal blood homeostasis 0.0354672960582366 0.211536906786612 1.19916698220371 0.228070175438596 17.1 17 1 abnormal craniofacial bone morphology 0.112753551969417 0.471028092727635 1.19916698220371 0.228070175438596 17.1 17 1 decreased litter size 0.00178194835726066 0.02491098116959 1.19752563675859 0.227758007117438 17.1 17 1 lethality, incomplete penetrance 0.154275951675902 0.508160024398681 1.19497409065754 0.227272727272727 17.1 17 1 intestinal ulcer 0.268576020613365 0.686997095938289 1.19497409065754 0.227272727272727 17.1 17 1 decreased airway responsiveness 0.268576020613365 0.686997095938289 1.19497409065754 0.227272727272727 17.1 17 1 abnormal chorion morphology 0.268576020613365 0.686997095938289 1.19497409065754 0.227272727272727 17.1 17 1 increased myocardial infarction size 0.268576020613365 0.686997095938289 1.19497409065754 0.227272727272727 17.1 17 1 abnormal lysosome physiology 0.268576020613365 0.686997095938289 1.19497409065754 0.227272727272727 17.1 17 1 abnormal cochlear sensory epithelium morphology 0.268576020613365 0.686997095938289 1.19497409065754 0.227272727272727 17.1 17 1 decreased cardiac output 0.268576020613365 0.686997095938289 1.19497409065754 0.227272727272727 17.1 17 1 abnormal occipital bone morphology 0.268576020613365 0.686997095938289 1.19497409065754 0.227272727272727 17.1 17 1 rough coat 0.268576020613365 0.686997095938289 1.19497409065754 0.227272727272727 17.1 17 1 kyphosis 0.0199583862684965 0.148419987572153 1.19178749308246 0.226666666666667 17.1 17 1 pericardial effusion 0.109312655108622 0.467966248440269 1.18726458039524 0.225806451612903 17.1 17 1 abnormal mitochondrial ATP synthesis coupled electron transport 0.216869931399175 0.612331389733767 1.18726458039524 0.225806451612903 17.1 17 1 abnormal ovary morphology 0.0928061647306546 0.408232245389042 1.18487571806044 0.225352112676056 17.1 17 1 abnormal posture 0.0791141419789156 0.368187891810201 1.18302434975097 0.225 17.1 17 1 polydactyly 0.0580326004477033 0.307628588051752 1.18034175485357 0.224489795918367 17.1 17 1 absent kidney 0.148865780215679 0.508160024398681 1.18034175485357 0.224489795918367 17.1 17 1 abnormal cranium morphology 0.0320339391917461 0.193408795484147 1.17713865646863 0.223880597014925 17.1 17 1 maternal effect 0.105861319266185 0.455194523205939 1.17713865646863 0.223880597014925 17.1 17 1 abnormal axon morphology 0.0547668727152114 0.296780111078577 1.16841911086515 0.222222222222222 17.1 17 1 increased circulating aspartate transaminase level 0.120903341180267 0.471028092727635 1.16841911086515 0.222222222222222 17.1 17 1 abnormal maxilla morphology 0.143514337232784 0.508160024398681 1.16841911086515 0.222222222222222 17.1 17 1 axon degeneration 0.143514337232784 0.508160024398681 1.16841911086515 0.222222222222222 17.1 17 1 abnormal ovarian follicle morphology 0.171644082348798 0.532982843163485 1.16841911086515 0.222222222222222 17.1 17 1 irregular heartbeat 0.171644082348798 0.532982843163485 1.16841911086515 0.222222222222222 17.1 17 1 albuminuria 0.171644082348798 0.532982843163485 1.16841911086515 0.222222222222222 17.1 17 1 cardiomyopathy 0.171644082348798 0.532982843163485 1.16841911086515 0.222222222222222 17.1 17 1 abnormal uterus morphology 0.207471155693769 0.589422535606359 1.16841911086515 0.222222222222222 17.1 17 1 abnormal epidermis stratum granulosum morphology 0.207471155693769 0.589422535606359 1.16841911086515 0.222222222222222 17.1 17 1 impaired wound healing 0.207471155693769 0.589422535606359 1.16841911086515 0.222222222222222 17.1 17 1 renal hypoplasia 0.207471155693769 0.589422535606359 1.16841911086515 0.222222222222222 17.1 17 1 abnormal heart valve morphology 0.254847846904299 0.671184774139166 1.16841911086515 0.222222222222222 17.1 17 1 abnormal trigeminal ganglion morphology 0.254847846904299 0.671184774139166 1.16841911086515 0.222222222222222 17.1 17 1 cryptorchism 0.254847846904299 0.671184774139166 1.16841911086515 0.222222222222222 17.1 17 1 abnormal fetal cardiomyocyte proliferation 0.254847846904299 0.671184774139166 1.16841911086515 0.222222222222222 17.1 17 1 abnormal bone trabecula morphology 0.254847846904299 0.671184774139166 1.16841911086515 0.222222222222222 17.1 17 1 increased or absent threshold for auditory brainstem response 0.00358904384035174 0.0431292104003621 1.1643761381632 0.221453287197232 17.1 17 1 cachexia 0.0618628305563578 0.314921786700319 1.16280171129369 0.221153846153846 17.1 17 1 decreased circulating alanine transaminase level 0.116732627099936 0.471028092727635 1.1598277938735 0.220588235294118 17.1 17 1 reduced male fertility 0.0101351981483182 0.0925185519043729 1.15812466935973 0.220264317180617 17.1 17 1 abnormal axon extension 0.164898059774265 0.514337208386814 1.1567349197565 0.22 17.1 17 1 decreased respiratory quotient 0.164898059774265 0.514337208386814 1.1567349197565 0.22 17.1 17 1 increased circulating glucose level 0.0372319485645597 0.220248447216034 1.15598912032404 0.219858156028369 17.1 17 1 small ovary 0.0816843949410756 0.375582130158827 1.15557934041609 0.21978021978022 17.1 17 1 liver fibrosis 0.198465271853551 0.579099546904055 1.15417009731802 0.219512195121951 17.1 17 1 decreased circulating LDL cholesterol level 0.13317556411131 0.505376377920495 1.15016256225789 0.21875 17.1 17 1 decreased caudal vertebrae number 0.13317556411131 0.505376377920495 1.15016256225789 0.21875 17.1 17 1 failure of primitive streak formation 0.242089309124014 0.660645864566509 1.15016256225789 0.21875 17.1 17 1 abnormal diaphragm morphology 0.242089309124014 0.660645864566509 1.15016256225789 0.21875 17.1 17 1 abnormal head morphology 0.158385310339563 0.508160024398681 1.14717512703124 0.218181818181818 17.1 17 1 abnormal contextual conditioning behavior 0.158385310339563 0.508160024398681 1.14717512703124 0.218181818181818 17.1 17 1 abnormal joint morphology 0.158385310339563 0.508160024398681 1.14717512703124 0.218181818181818 17.1 17 1 abnormal inner ear morphology 0.189886797009649 0.556680503902772 1.14301869541156 0.217391304347826 17.1 17 1 fragile skeleton 0.301772037620049 0.693128295087601 1.14301869541156 0.217391304347826 17.1 17 1 abnormal blood vessel physiology 0.301772037620049 0.693128295087601 1.14301869541156 0.217391304347826 17.1 17 1 abnormal pulmonary artery morphology 0.301772037620049 0.693128295087601 1.14301869541156 0.217391304347826 17.1 17 1 bidirectional circling 0.301772037620049 0.693128295087601 1.14301869541156 0.217391304347826 17.1 17 1 failure of embryo implantation 0.301772037620049 0.693128295087601 1.14301869541156 0.217391304347826 17.1 17 1 abnormal corneal stroma morphology 0.301772037620049 0.693128295087601 1.14301869541156 0.217391304347826 17.1 17 1 abnormal coat appearance 0.128236486657175 0.487377021481623 1.14301869541156 0.217391304347826 17.1 17 1 short tail 0.104835081667916 0.45234564726616 1.14026443349491 0.216867469879518 17.1 17 1 increased circulating phosphate level 0.230241175712402 0.647146807440226 1.13684021597691 0.216216216216216 17.1 17 1 impaired skeletal muscle contractility 0.230241175712402 0.647146807440226 1.13684021597691 0.216216216216216 17.1 17 1 increased anxiety-related response 0.04950414733808 0.276455793714801 1.13479553932947 0.215827338129496 17.1 17 1 abnormal gastrulation 0.181737774797424 0.538048083618566 1.13405384289853 0.215686274509804 17.1 17 1 microphthalmia 0.041397669148012 0.240542666167392 1.13405384289853 0.215686274509804 17.1 17 1 hyperactivity 0.00271160134233032 0.0349487478707082 1.13377595663465 0.215633423180593 17.1 17 1 lethargy 0.0974983417989034 0.426107774683257 1.13072817180499 0.21505376344086 17.1 17 1 abnormal nervous system electrophysiology 0.114439307413648 0.471028092727635 1.12668985690568 0.214285714285714 17.1 17 1 abnormal action potential 0.140364066972976 0.508160024398681 1.12668985690568 0.214285714285714 17.1 17 1 abnormal eye development 0.174005342471415 0.534038605055699 1.12668985690568 0.214285714285714 17.1 17 1 abnormal jaw morphology 0.284023745174473 0.686997095938289 1.12668985690568 0.214285714285714 17.1 17 1 hypoxia 0.284023745174473 0.686997095938289 1.12668985690568 0.214285714285714 17.1 17 1 decreased circulating progesterone level 0.284023745174473 0.686997095938289 1.12668985690568 0.214285714285714 17.1 17 1 prolonged QRS complex duration 0.284023745174473 0.686997095938289 1.12668985690568 0.214285714285714 17.1 17 1 abnormal gait 0.00745107635974088 0.0722594637226333 1.12304361141408 0.213592233009709 17.1 17 1 abnormal maternal nurturing 0.166670055066105 0.519538548843277 1.12053308173134 0.213114754098361 17.1 17 1 abnormal tooth development 0.268170251805218 0.686997095938289 1.11530915128037 0.212121212121212 17.1 17 1 abnormal aorta morphology 0.268170251805218 0.686997095938289 1.11530915128037 0.212121212121212 17.1 17 1 dextrocardia 0.268170251805218 0.686997095938289 1.11530915128037 0.212121212121212 17.1 17 1 abnormal ovarian folliculogenesis 0.268170251805218 0.686997095938289 1.11530915128037 0.212121212121212 17.1 17 1 absent vibrissae 0.268170251805218 0.686997095938289 1.11530915128037 0.212121212121212 17.1 17 1 diarrhea 0.268170251805218 0.686997095938289 1.11530915128037 0.212121212121212 17.1 17 1 absent corpus luteum 0.199339209456089 0.579667393440276 1.11224511515048 0.211538461538462 17.1 17 1 increased percent body fat/body weight 0.199339209456089 0.579667393440276 1.11224511515048 0.211538461538462 17.1 17 1 corneal opacity 0.153102790787883 0.508160024398681 1.11082098568166 0.211267605633803 17.1 17 1 prenatal lethality 0.181887324442579 0.538048083618566 1.10245996750986 0.209677419354839 17.1 17 1 decreased oxygen consumption 0.240763594254344 0.660645864566509 1.1004877672102 0.209302325581395 17.1 17 1 abnormal urine homeostasis 0.124640227472375 0.478830217509702 1.09539291643608 0.208333333333333 17.1 17 1 abnormal cardiovascular system morphology 0.228750841756367 0.643685202340456 1.09539291643608 0.208333333333333 17.1 17 1 abnormal kidney physiology 0.228750841756367 0.643685202340456 1.09539291643608 0.208333333333333 17.1 17 1 blindness 0.335536817919985 0.7515964291544 1.09539291643608 0.208333333333333 17.1 17 1 abnormal sensory capabilities/reflexes/nociception 0.335536817919985 0.7515964291544 1.09539291643608 0.208333333333333 17.1 17 1 abnormal impulse conducting system conduction 0.335536817919985 0.7515964291544 1.09539291643608 0.208333333333333 17.1 17 1 abnormal retinal ganglion layer morphology 0.335536817919985 0.7515964291544 1.09539291643608 0.208333333333333 17.1 17 1 decreased fatty acid level 0.335536817919985 0.7515964291544 1.09539291643608 0.208333333333333 17.1 17 1 abnormal spermiogenesis 0.207346328720671 0.589422535606359 1.08783848252963 0.206896551724138 17.1 17 1 abnormal eye electrophysiology 0.102259259321023 0.44199810175681 1.08634008241595 0.206611570247934 17.1 17 1 gliosis 0.19774316009078 0.57733111587537 1.08496060294621 0.206349206349206 17.1 17 1 increased circulating insulin level 0.0703268033825921 0.332581603449045 1.08443898727172 0.20625 17.1 17 1 lung hemorrhage 0.29495473753253 0.686997095938289 1.0825059409486 0.205882352941176 17.1 17 1 abnormal vision 0.29495473753253 0.686997095938289 1.0825059409486 0.205882352941176 17.1 17 1 increased susceptibility to weight gain 0.29495473753253 0.686997095938289 1.0825059409486 0.205882352941176 17.1 17 1 abnormal motor capabilities/coordination/movement 0.101631657671184 0.43966738862099 1.07547668159179 0.204545454545455 17.1 17 1 hypertension 0.263003273774516 0.686997095938289 1.07547668159179 0.204545454545455 17.1 17 1 abnormal gametogenesis 0.263003273774516 0.686997095938289 1.07547668159179 0.204545454545455 17.1 17 1 omphalocele 0.263003273774516 0.686997095938289 1.07547668159179 0.204545454545455 17.1 17 1 cochlear hair cell degeneration 0.263003273774516 0.686997095938289 1.07547668159179 0.204545454545455 17.1 17 1 abnormal amino acid level 0.263003273774516 0.686997095938289 1.07547668159179 0.204545454545455 17.1 17 1 abnormal craniofacial morphology 0.139037151662641 0.508160024398681 1.07199617453162 0.203883495145631 17.1 17 1 abnormal cochlea morphology 0.236615974779293 0.660645864566509 1.07105085162639 0.203703703703704 17.1 17 1 abnormal neuronal precursor proliferation 0.236615974779293 0.660645864566509 1.07105085162639 0.203703703703704 17.1 17 1 respiratory distress 0.0799652252933285 0.370416197238649 1.06373416162579 0.202312138728324 17.1 17 1 cleft secondary palate 0.162749500587117 0.508911857586994 1.06276419126565 0.202127659574468 17.1 17 1 deafness 0.1558502120999 0.508160024398681 1.06219919169559 0.202020202020202 17.1 17 1 abnormal CNS synaptic transmission 0.1558502120999 0.508160024398681 1.06219919169559 0.202020202020202 17.1 17 1 abnormal hindlimb morphology 0.270318223643138 0.686997095938289 1.05157719977864 0.2 17.1 17 1 increased circulating corticosterone level 0.285843071630945 0.686997095938289 1.05157719977864 0.2 17.1 17 1 abnormal heart tube morphology 0.344168708575473 0.765296687118889 1.05157719977864 0.2 17.1 17 1 emphysema 0.344168708575473 0.765296687118889 1.05157719977864 0.2 17.1 17 1 liver hemorrhage 0.344168708575473 0.765296687118889 1.05157719977864 0.2 17.1 17 1 abnormal optic cup morphology 0.344168708575473 0.765296687118889 1.05157719977864 0.2 17.1 17 1 abnormal primitive streak morphology 0.369581278170015 0.802222534053809 1.05157719977864 0.2 17.1 17 1 decreased placenta weight 0.369581278170015 0.802222534053809 1.05157719977864 0.2 17.1 17 1 abnormal preimplantation embryo development 0.369581278170015 0.802222534053809 1.05157719977864 0.2 17.1 17 1 increased liver glycogen level 0.369581278170015 0.802222534053809 1.05157719977864 0.2 17.1 17 1 thick epidermis 0.220123037942067 0.62116398965501 1.05157719977864 0.2 17.1 17 1 abnormal female reproductive system morphology 0.303032893571323 0.695703112836794 1.05157719977864 0.2 17.1 17 1 abnormal embryonic epiblast morphology 0.322282974401193 0.724517757634855 1.05157719977864 0.2 17.1 17 1 holoprosencephaly 0.322282974401193 0.724517757634855 1.05157719977864 0.2 17.1 17 1 atelectasis 0.236584151278182 0.660645864566509 1.03676625330288 0.197183098591549 17.1 17 1 abnormal skin morphology 0.248763642040393 0.664312535336595 1.0356442119032 0.196969696969697 17.1 17 1 increased body weight 0.0819522509518367 0.376118494912719 1.03279903549688 0.196428571428571 17.1 17 1 short mandible 0.276259224946913 0.686997095938289 1.03279903549688 0.196428571428571 17.1 17 1 enhanced long term potentiation 0.276259224946913 0.686997095938289 1.03279903549688 0.196428571428571 17.1 17 1 obese 0.241224827143092 0.660645864566509 1.02426350627789 0.194805194805195 17.1 17 1 abnormal heart left ventricle morphology 0.253516359663472 0.66945004741283 1.02236672200701 0.194444444444444 17.1 17 1 short snout 0.194534684076924 0.568297154012154 1.02236672200701 0.194444444444444 17.1 17 1 absent mature ovarian follicles 0.374720415097785 0.802857047851627 1.01765535462449 0.193548387096774 17.1 17 1 abnormal body temperature homeostasis 0.374720415097785 0.802857047851627 1.01765535462449 0.193548387096774 17.1 17 1 increased lung adenoma incidence 0.374720415097785 0.802857047851627 1.01765535462449 0.193548387096774 17.1 17 1 abnormal retinal photoreceptor layer morphology 0.374720415097785 0.802857047851627 1.01765535462449 0.193548387096774 17.1 17 1 abnormal facial morphology 0.2968053290431 0.686997095938289 1.01467975417237 0.192982456140351 17.1 17 1 decreased cardiac muscle contractility 0.216340043012047 0.611182120377588 1.01113192286408 0.192307692307692 17.1 17 1 increased circulating alanine transaminase level 0.257604028387118 0.678084677897307 1.01113192286408 0.192307692307692 17.1 17 1 abnormal skin condition 0.31396702109753 0.70934874203461 1.01113192286408 0.192307692307692 17.1 17 1 abnormal brain wave pattern 0.31396702109753 0.70934874203461 1.01113192286408 0.192307692307692 17.1 17 1 thick skin 0.403635111802614 0.807750746604753 1.01113192286408 0.192307692307692 17.1 17 1 arrest of spermatogenesis 0.26114120547436 0.686668867460327 1.00150209502727 0.19047619047619 17.1 17 1 decreased exploration in new environment 0.26114120547436 0.686668867460327 1.00150209502727 0.19047619047619 17.1 17 1 abnormal muscle morphology 0.354067871914078 0.783579921162161 1.00150209502727 0.19047619047619 17.1 17 1 abnormal enzyme/coenzyme level 0.317742541884519 0.71722738016129 0.997185275652157 0.189655172413793 17.1 17 1 abnormal breathing pattern 0.377939004492051 0.807750746604753 0.994735188979793 0.189189189189189 17.1 17 1 decreased circulating chloride level 0.377939004492051 0.807750746604753 0.994735188979793 0.189189189189189 17.1 17 1 increased insulin secretion 0.377939004492051 0.807750746604753 0.994735188979793 0.189189189189189 17.1 17 1 abnormal humerus morphology 0.377939004492051 0.807750746604753 0.994735188979793 0.189189189189189 17.1 17 1 abnormal mesoderm development 0.336366136145748 0.752437737106609 0.992053962055319 0.188679245283019 17.1 17 1 enlarged kidney 0.336366136145748 0.752437737106609 0.992053962055319 0.188679245283019 17.1 17 1 increased circulating bilirubin level 0.336366136145748 0.752437737106609 0.992053962055319 0.188679245283019 17.1 17 1 hyperkeratosis 0.304032189094349 0.697353684068413 0.990616202690022 0.188405797101449 17.1 17 1 abnormal food intake 0.304032189094349 0.697353684068413 0.990616202690022 0.188405797101449 17.1 17 1 abnormal tooth morphology 0.320753232263211 0.723694934471417 0.985853624792474 0.1875 17.1 17 1 polydipsia 0.405327593399425 0.807750746604753 0.985853624792474 0.1875 17.1 17 1 increased circulating follicle stimulating hormone level 0.405327593399425 0.807750746604753 0.985853624792474 0.1875 17.1 17 1 abnormal lymphatic vessel morphology 0.405327593399425 0.807750746604753 0.985853624792474 0.1875 17.1 17 1 abnormal serotonin level 0.405327593399425 0.807750746604753 0.985853624792474 0.1875 17.1 17 1 abnormal coat/hair pigmentation 0.245670176203224 0.660645864566509 0.985853624792474 0.1875 17.1 17 1 abnormal neuron differentiation 0.245670176203224 0.660645864566509 0.985853624792474 0.1875 17.1 17 1 abnormal locomotor activation 0.279966221123623 0.686997095938289 0.982242439353673 0.186813186813187 17.1 17 1 domed cranium 0.323169363918554 0.726182287938034 0.976464542651593 0.185714285714286 17.1 17 1 abnormal long bone epiphyseal plate proliferative zone 0.359036627365397 0.794065635081895 0.973682592387628 0.185185185185185 17.1 17 1 rectal prolapse 0.437450399279504 0.84962028443003 0.973682592387628 0.185185185185185 17.1 17 1 seizures 0.273139219887772 0.686997095938289 0.968557947164536 0.184210526315789 17.1 17 1 persistence of hyaloid vascular system 0.40596174225513 0.807750746604753 0.968557947164536 0.184210526315789 17.1 17 1 abnormal retinal outer nuclear layer morphology 0.40596174225513 0.807750746604753 0.968557947164536 0.184210526315789 17.1 17 1 abnormal response/metabolism to endogenous compounds 0.326678805203562 0.733736819813869 0.961808414431682 0.182926829268293 17.1 17 1 abnormal photoreceptor outer segment morphology 0.40595770779924 0.807750746604753 0.955979272526035 0.181818181818182 17.1 17 1 belly spot 0.435807002642581 0.84962028443003 0.955979272526035 0.181818181818182 17.1 17 1 decreased systemic arterial blood pressure 0.435807002642581 0.84962028443003 0.955979272526035 0.181818181818182 17.1 17 1 dilated heart atrium 0.435807002642581 0.84962028443003 0.955979272526035 0.181818181818182 17.1 17 1 single kidney 0.435807002642581 0.84962028443003 0.955979272526035 0.181818181818182 17.1 17 1 cardiovascular system phenotype 0.435807002642581 0.84962028443003 0.955979272526035 0.181818181818182 17.1 17 1 decreased circulating alkaline phosphatase level 0.405545006231052 0.807750746604753 0.946419479800775 0.18 17.1 17 1 decreased rib number 0.345275568766531 0.765296687118889 0.945237932385293 0.179775280898876 17.1 17 1 abnormal excitatory postsynaptic currents 0.362601917996787 0.797147389321263 0.943723128006471 0.179487179487179 17.1 17 1 abnormal iris morphology 0.433922043711147 0.84962028443003 0.943723128006471 0.179487179487179 17.1 17 1 rib fusion 0.382199043798117 0.807750746604753 0.9417109251749 0.17910447761194 17.1 17 1 impaired righting response 0.345714083660136 0.765432828753527 0.940884862959835 0.178947368421053 17.1 17 1 reduced long term potentiation 0.330759444675067 0.7425668940697 0.93890821408807 0.178571428571429 17.1 17 1 abnormal seminal vesicle morphology 0.404859382686641 0.807750746604753 0.93890821408807 0.178571428571429 17.1 17 1 myoclonus 0.470804019737119 0.89615597031436 0.93890821408807 0.178571428571429 17.1 17 1 reddish skin 0.470804019737119 0.89615597031436 0.93890821408807 0.178571428571429 17.1 17 1 straub tail 0.470804019737119 0.89615597031436 0.93890821408807 0.178571428571429 17.1 17 1 abnormal retinal inner nuclear layer morphology 0.470804019737119 0.89615597031436 0.93890821408807 0.178571428571429 17.1 17 1 abnormal rib morphology 0.317611749616906 0.71722738016129 0.934735288692123 0.177777777777778 17.1 17 1 abnormal retinal photoreceptor morphology 0.46598963088045 0.89615597031436 0.927862235098799 0.176470588235294 17.1 17 1 overexpanded pulmonary alveoli 0.46598963088045 0.89615597031436 0.927862235098799 0.176470588235294 17.1 17 1 thin skin 0.46598963088045 0.89615597031436 0.927862235098799 0.176470588235294 17.1 17 1 impaired ovarian folliculogenesis 0.461686408892321 0.893036502425854 0.920130049806309 0.175 17.1 17 1 head bobbing 0.461686408892321 0.893036502425854 0.920130049806309 0.175 17.1 17 1 increased susceptibility to weight loss 0.461686408892321 0.893036502425854 0.920130049806309 0.175 17.1 17 1 abnormal spinal nerve morphology 0.503499017054552 0.898782780712736 0.906532068774689 0.172413793103448 17.1 17 1 increased retinal apoptosis 0.503499017054552 0.898782780712736 0.906532068774689 0.172413793103448 17.1 17 1 decreased anxiety-related response 0.407213261912945 0.80809173435058 0.89768785346957 0.170731707317073 17.1 17 1 abnormal excitatory postsynaptic potential 0.439079438420022 0.850299807761623 0.89768785346957 0.170731707317073 17.1 17 1 Leydig cell hyperplasia 0.48913130659549 0.89615597031436 0.89768785346957 0.170731707317073 17.1 17 1 lethality at weaning, incomplete penetrance 0.48913130659549 0.89615597031436 0.89768785346957 0.170731707317073 17.1 17 1 short femur 0.436480297742935 0.84962028443003 0.896230567993158 0.170454545454545 17.1 17 1 abnormal eye physiology 0.496221605072532 0.89615597031436 0.876314333148866 0.166666666666667 17.1 17 1 oligodactyly 0.508661356046627 0.907346807576898 0.876314333148866 0.166666666666667 17.1 17 1 curly tail 0.508661356046627 0.907346807576898 0.876314333148866 0.166666666666667 17.1 17 1 abnormal systemic arterial blood pressure 0.52486721667493 0.932427721589224 0.876314333148866 0.166666666666667 17.1 17 1 heart right ventricle hypertrophy 0.52486721667493 0.932427721589224 0.876314333148866 0.166666666666667 17.1 17 1 abnormal reflex 0.52486721667493 0.932427721589224 0.876314333148866 0.166666666666667 17.1 17 1 head tilt 0.52486721667493 0.932427721589224 0.876314333148866 0.166666666666667 17.1 17 1 enhanced paired-pulse facilitation 0.535365078750368 0.949195034491475 0.876314333148866 0.166666666666667 17.1 17 1 decreased food intake 0.501208606615812 0.89615597031436 0.86522174665331 0.164556962025316 17.1 17 1 abnormal lens morphology 0.484671436246614 0.89615597031436 0.862621921693415 0.1640625 17.1 17 1 abnormal vocalization 0.553304935161939 0.971995781225512 0.85263016198268 0.162162162162162 17.1 17 1 preaxial polydactyly 0.566258283298941 0.983678272199084 0.848046128853741 0.161290322580645 17.1 17 1 abnormal intestine physiology 0.566258283298941 0.983678272199084 0.848046128853741 0.161290322580645 17.1 17 1 increased circulating chloride level 0.557909341535632 0.979392721997096 0.841261759822911 0.16 17.1 17 1 testicular atrophy 0.557909341535632 0.979392721997096 0.841261759822911 0.16 17.1 17 1 increased grooming behavior 0.580931783831966 0.983678272199084 0.83019252614103 0.157894736842105 17.1 17 1 impaired branching involved in ureteric bud morphogenesis 0.580931783831966 0.983678272199084 0.83019252614103 0.157894736842105 17.1 17 1 increased startle reflex 0.570315951267348 0.983678272199084 0.827083190837131 0.157303370786517 17.1 17 1 increased kidney weight 0.58172642205484 0.984049285862914 0.824766431198932 0.156862745098039 17.1 17 1 increased susceptibility to pharmacologically induced seizures 0.580846145135017 0.983678272199084 0.821544687327062 0.15625 17.1 17 1 abnormal lumbar vertebrae morphology 0.596060262909963 0.998115048124222 0.821544687327062 0.15625 17.1 17 1 polyuria 0.585735477927122 0.989149355969935 0.819410805022316 0.155844155844156 17.1 17 1 abnormal metabolism 0.593632641308304 0.99467350043839 0.817893377605608 0.155555555555556 17.1 17 1 abnormal lens fiber morphology 0.607660827490297 1 0.808905538291261 0.153846153846154 17.1 17 1 abnormal neuromuscular synapse morphology 0.614104046268976 1 0.803288138719793 0.152777777777778 17.1 17 1 abnormal digit morphology 0.614104046268976 1 0.803288138719793 0.152777777777778 17.1 17 1 impaired swimming 0.624511412043496 1 0.796649393771696 0.151515151515152 17.1 17 1 abnormal tail morphology 0.624511412043496 1 0.796649393771696 0.151515151515152 17.1 17 1 head tossing 0.624676916529138 1 0.796649393771696 0.151515151515152 17.1 17 1 abnormal coat/ hair morphology 0.627440445376837 1 0.793643169644256 0.150943396226415 17.1 17 1 short limbs 0.648925485004559 1 0.785661126271397 0.149425287356322 17.1 17 1 abnormal tibia morphology 0.641580304267383 1 0.783089404090476 0.148936170212766 17.1 17 1 polyphagia 0.649240183528254 1 0.778946073910103 0.148148148148148 17.1 17 1 abnormal inhibitory postsynaptic currents 0.663319510825087 1 0.773218529248999 0.147058823529412 17.1 17 1 abnormal limb morphology 0.669837246886832 1 0.771156613171002 0.146666666666667 17.1 17 1 short humerus 0.658156398278232 1 0.769446731545345 0.146341463414634 17.1 17 1 abnormal axial skeleton morphology 0.687340960459651 1 0.761009815629278 0.144736842105263 17.1 17 1 abnormal optic nerve morphology 0.681825132402642 1 0.751126571270456 0.142857142857143 17.1 17 1 dehydration 0.69971167422859 1 0.751126571270456 0.142857142857143 17.1 17 1 decreased urine osmolality 0.686064239122737 1 0.751126571270456 0.142857142857143 17.1 17 1 circling 0.72434634176181 1 0.742289788079039 0.141176470588235 17.1 17 1 increased body length 0.706926664311335 1 0.736104039845047 0.14 17.1 17 1 decreased oocyte number 0.706926664311335 1 0.736104039845047 0.14 17.1 17 1 abnormal pharyngeal arch morphology 0.702802483308563 1 0.730261944290721 0.138888888888889 17.1 17 1 abnormal thoracic vertebrae morphology 0.746428557933074 1 0.712933694765179 0.135593220338983 17.1 17 1 abnormal cartilage development 0.746202050323608 1 0.701051466519092 0.133333333333333 17.1 17 1 decreased threshold for auditory brainstem response 0.748165973899581 1 0.691827105117525 0.131578947368421 17.1 17 1 abnormal forelimb morphology 0.765429605703983 1 0.685811217246938 0.130434782608696 17.1 17 1 abnormal heart looping 0.768828495430357 1 0.67408794857605 0.128205128205128 17.1 17 1 acanthosis 0.768828495430357 1 0.67408794857605 0.128205128205128 17.1 17 1 abnormal innervation 0.783553893719095 1 0.671219489220408 0.127659574468085 17.1 17 1 abnormal social investigation 0.842570806096198 1 0.657235749861649 0.125 17.1 17 1 abnormal cued conditioning behavior 0.845484401621253 1 0.618574823399199 0.117647058823529 17.1 17 1 abnormal craniofacial development 0.91009392185911 1 0.536518979478897 0.102040816326531 17.1 17 1 syndactyly 0.926236720512536 1 0.534700271073884 0.101694915254237 17.1 17 1 abnormal femur morphology 0.987819672191603 1 0.392379552156208 0.0746268656716418 17.1 17 1 liver failure 0.000188542208587372 0.00248147483524385 1.92070598364184 1 17.2 17 2 elevated level of mitotic sister chromatid exchange 0.000188542208587372 0.00248147483524385 1.92070598364184 1 17.2 17 2 abnormal mitotic spindle assembly checkpoint 0.000188542208587372 0.00248147483524385 1.92070598364184 1 17.2 17 2 pleural effusion 0.000188542208587372 0.00248147483524385 1.92070598364184 1 17.2 17 2 broad head 0.000550894735411604 0.0062147421965368 1.92070598364184 1 17.2 17 2 decreased mortality induced by ionizing radiation 0.000550894735411604 0.0062147421965368 1.92070598364184 1 17.2 17 2 absent popliteal lymph nodes 0.000550894735411604 0.0062147421965368 1.92070598364184 1 17.2 17 2 heart hemorrhage 0.000550894735411604 0.0062147421965368 1.92070598364184 1 17.2 17 2 increased circulating fructosamine level 2.20807943414871e-05 0.000402388102010617 1.92070598364184 1 17.2 17 2 dissociated hepatocytes 0.00470234909039873 0.0351437345658924 1.92070598364184 1 17.2 17 2 abnormal respiratory sounds 0.00470234909039873 0.0351437345658924 1.92070598364184 1 17.2 17 2 abnormal type I pneumocyte morphology 0.00470234909039873 0.0351437345658924 1.92070598364184 1 17.2 17 2 abnormal response to vitamins 0.00470234909039873 0.0351437345658924 1.92070598364184 1 17.2 17 2 corneal deposits 0.00470234909039873 0.0351437345658924 1.92070598364184 1 17.2 17 2 decreased leukotriene level 0.00470234909039873 0.0351437345658924 1.92070598364184 1 17.2 17 2 increased T follicular helper cell number 0.00470234909039873 0.0351437345658924 1.92070598364184 1 17.2 17 2 increased renal carcinoma incidence 0.00470234909039873 0.0351437345658924 1.92070598364184 1 17.2 17 2 prolonged ST segment 0.00470234909039873 0.0351437345658924 1.92070598364184 1 17.2 17 2 decreased fibroblast chemotaxis 0.00470234909039873 0.0351437345658924 1.92070598364184 1 17.2 17 2 abnormal leukocyte tethering or rolling 0.00160954842240424 0.0150800440705482 1.92070598364184 1 17.2 17 2 impaired granulocyte bactericidal activity 0.00160954842240424 0.0150800440705482 1.92070598364184 1 17.2 17 2 thymus cortex atrophy 0.00160954842240424 0.0150800440705482 1.92070598364184 1 17.2 17 2 loss of cortex neurons 0.000167330673731779 0.00224385472187493 1.74609634876531 0.909090909090909 17.2 17 2 increased glycogen level 0.000167330673731779 0.00224385472187493 1.74609634876531 0.909090909090909 17.2 17 2 abnormal immune cell physiology 0.000446516811026163 0.00523920078975274 1.72863538527766 0.9 17.2 17 2 decreased transitional stage T2 B cell number 0.000446516811026163 0.00523920078975274 1.72863538527766 0.9 17.2 17 2 decreased macrophage cytokine production 0.000446516811026163 0.00523920078975274 1.72863538527766 0.9 17.2 17 2 decreased macrophage apoptosis 0.000446516811026163 0.00523920078975274 1.72863538527766 0.9 17.2 17 2 decreased level of surface class I molecules 0.00118068470920671 0.0115120892182566 1.70729420768164 0.888888888888889 17.2 17 2 increased neuronal precursor cell number 0.00118068470920671 0.0115120892182566 1.70729420768164 0.888888888888889 17.2 17 2 decreased susceptibility to atherosclerosis 0.00118068470920671 0.0115120892182566 1.70729420768164 0.888888888888889 17.2 17 2 positive geotaxis 0.00118068470920671 0.0115120892182566 1.70729420768164 0.888888888888889 17.2 17 2 increased myeloid cell number 0.00118068470920671 0.0115120892182566 1.70729420768164 0.888888888888889 17.2 17 2 increased cardiac muscle glycogen level 0.00118068470920671 0.0115120892182566 1.70729420768164 0.888888888888889 17.2 17 2 cerebellum atrophy 0.00118068470920671 0.0115120892182566 1.70729420768164 0.888888888888889 17.2 17 2 tau protein deposits 0.00308736242318123 0.0254298477737195 1.68061773568661 0.875 17.2 17 2 abnormal lateral ganglionic eminence morphology 0.00308736242318123 0.0254298477737195 1.68061773568661 0.875 17.2 17 2 accumulation of giant lysosomes in kidney/renal tubule cells 0.00308736242318123 0.0254298477737195 1.68061773568661 0.875 17.2 17 2 craniofacial phenotype 0.00308736242318123 0.0254298477737195 1.68061773568661 0.875 17.2 17 2 enlarged inguinal lymph nodes 0.00308736242318123 0.0254298477737195 1.68061773568661 0.875 17.2 17 2 abnormal cerebellum deep nucleus morphology 0.00308736242318123 0.0254298477737195 1.68061773568661 0.875 17.2 17 2 abnormal macrophage activation involved in immune response 0.00308736242318123 0.0254298477737195 1.68061773568661 0.875 17.2 17 2 increased testis apoptosis 0.00308736242318123 0.0254298477737195 1.68061773568661 0.875 17.2 17 2 decreased white adipose tissue mass 0.00308736242318123 0.0254298477737195 1.68061773568661 0.875 17.2 17 2 increased brain apoptosis 0.00308736242318123 0.0254298477737195 1.68061773568661 0.875 17.2 17 2 decreased vascular endothelial cell proliferation 0.00308736242318123 0.0254298477737195 1.68061773568661 0.875 17.2 17 2 abnormal lymph node B cell domain morphology 4.32877933166382e-05 0.000715471002492608 1.6646118524896 0.866666666666667 17.2 17 2 decreased brown adipose tissue mass 4.32877933166382e-05 0.000715471002492608 1.6646118524896 0.866666666666667 17.2 17 2 increased mortality induced by gamma-irradiation 1.0953556023803e-08 4.03658823840149e-07 1.6557810203809 0.862068965517241 17.2 17 2 increased hemangioma incidence 0.000110264507973121 0.00158088163448495 1.64631941455015 0.857142857142857 17.2 17 2 abnormal vascular endothelial cell migration 0.000110264507973121 0.00158088163448495 1.64631941455015 0.857142857142857 17.2 17 2 lysosomal protein accumulation 0.000110264507973121 0.00158088163448495 1.64631941455015 0.857142857142857 17.2 17 2 decreased compact bone area 0.000110264507973121 0.00158088163448495 1.64631941455015 0.857142857142857 17.2 17 2 abnormal circulating free fatty acids level 0.00796147054436003 0.0524613456399883 1.64631941455015 0.857142857142857 17.2 17 2 abnormal gastrulation movements 0.00796147054436003 0.0524613456399883 1.64631941455015 0.857142857142857 17.2 17 2 aorta coarctation 0.00796147054436003 0.0524613456399883 1.64631941455015 0.857142857142857 17.2 17 2 increased cell nucleus count 0.00796147054436003 0.0524613456399883 1.64631941455015 0.857142857142857 17.2 17 2 abnormal negative T cell selection 0.00796147054436003 0.0524613456399883 1.64631941455015 0.857142857142857 17.2 17 2 decreased DN2 thymocyte number 0.00796147054436003 0.0524613456399883 1.64631941455015 0.857142857142857 17.2 17 2 decreased DN4 thymocyte number 0.00796147054436003 0.0524613456399883 1.64631941455015 0.857142857142857 17.2 17 2 decreased brain cholesterol level 0.00796147054436003 0.0524613456399883 1.64631941455015 0.857142857142857 17.2 17 2 focal dorsal hair loss 0.00796147054436003 0.0524613456399883 1.64631941455015 0.857142857142857 17.2 17 2 thick mitral valve cusps 0.00796147054436003 0.0524613456399883 1.64631941455015 0.857142857142857 17.2 17 2 embryo tumor 0.00796147054436003 0.0524613456399883 1.64631941455015 0.857142857142857 17.2 17 2 abnormal coping response 0.000278027869917377 0.00345797163209738 1.62521275538925 0.846153846153846 17.2 17 2 abnormal neutrophil morphology 2.65516755456697e-05 0.000473457296916511 1.60058831970154 0.833333333333333 17.2 17 2 increased effector memory CD8-positive, alpha-beta T cell number 2.65516755456697e-05 0.000473457296916511 1.60058831970154 0.833333333333333 17.2 17 2 decreased red blood cell distribution width 0.000692830886096137 0.00741254550178125 1.60058831970154 0.833333333333333 17.2 17 2 increased fibrosarcoma incidence 0.000692830886096137 0.00741254550178125 1.60058831970154 0.833333333333333 17.2 17 2 prenatal growth retardation 0.000692830886096137 0.00741254550178125 1.60058831970154 0.833333333333333 17.2 17 2 echinocytosis 0.0201663524303712 0.107763268894841 1.60058831970154 0.833333333333333 17.2 17 2 absent ectoplacental cone 0.0201663524303712 0.107763268894841 1.60058831970154 0.833333333333333 17.2 17 2 delayed brain development 0.0201663524303712 0.107763268894841 1.60058831970154 0.833333333333333 17.2 17 2 abnormal lymph organ size 0.0201663524303712 0.107763268894841 1.60058831970154 0.833333333333333 17.2 17 2 abnormal lymph node cortex morphology 0.0201663524303712 0.107763268894841 1.60058831970154 0.833333333333333 17.2 17 2 decreased liver function 0.0201663524303712 0.107763268894841 1.60058831970154 0.833333333333333 17.2 17 2 rheumatoid arthritis 0.0201663524303712 0.107763268894841 1.60058831970154 0.833333333333333 17.2 17 2 abnormal metopic suture morphology 0.0201663524303712 0.107763268894841 1.60058831970154 0.833333333333333 17.2 17 2 abnormal cholesterol level 0.0201663524303712 0.107763268894841 1.60058831970154 0.833333333333333 17.2 17 2 abnormal physical strength 0.0201663524303712 0.107763268894841 1.60058831970154 0.833333333333333 17.2 17 2 small clavicle 0.0201663524303712 0.107763268894841 1.60058831970154 0.833333333333333 17.2 17 2 osteomyelitis 0.0201663524303712 0.107763268894841 1.60058831970154 0.833333333333333 17.2 17 2 abnormal ligament morphology 0.0201663524303712 0.107763268894841 1.60058831970154 0.833333333333333 17.2 17 2 abnormal olfactory bulb layer morphology 0.0201663524303712 0.107763268894841 1.60058831970154 0.833333333333333 17.2 17 2 abnormal oval cell physiology 0.0201663524303712 0.107763268894841 1.60058831970154 0.833333333333333 17.2 17 2 absent third pharyngeal arch 0.0201663524303712 0.107763268894841 1.60058831970154 0.833333333333333 17.2 17 2 thick myocardium 0.0201663524303712 0.107763268894841 1.60058831970154 0.833333333333333 17.2 17 2 decreased macrophage nitric oxide production 0.0201663524303712 0.107763268894841 1.60058831970154 0.833333333333333 17.2 17 2 abnormal endocrine pancreas development 0.0201663524303712 0.107763268894841 1.60058831970154 0.833333333333333 17.2 17 2 delayed limb development 0.0201663524303712 0.107763268894841 1.60058831970154 0.833333333333333 17.2 17 2 increased bone trabecular spacing 0.0201663524303712 0.107763268894841 1.60058831970154 0.833333333333333 17.2 17 2 increased effector memory T-helper cell number 0.0201663524303712 0.107763268894841 1.60058831970154 0.833333333333333 17.2 17 2 abnormal Wolffian duct connection 0.0201663524303712 0.107763268894841 1.60058831970154 0.833333333333333 17.2 17 2 liver hypoplasia 8.74893216973038e-13 7.02031250716268e-11 1.58827610185768 0.826923076923077 17.2 17 2 abnormal adipose tissue morphology 6.51003713364379e-05 0.00101062663928431 1.58175786888152 0.823529411764706 17.2 17 2 abnormal lysosome physiology 6.35401233897034e-06 0.000129025352597459 1.57148671388878 0.818181818181818 17.2 17 2 pulmonary vascular congestion 6.35401233897034e-06 0.000129025352597459 1.57148671388878 0.818181818181818 17.2 17 2 impaired myelopoiesis 0.0017028544288509 0.0158943729522199 1.57148671388878 0.818181818181818 17.2 17 2 abnormal radial glial cell morphology 0.0017028544288509 0.0158943729522199 1.57148671388878 0.818181818181818 17.2 17 2 decreased fibroblast apoptosis 0.000157878435942368 0.00212857782876228 1.560573611709 0.8125 17.2 17 2 increased acute inflammation 1.52934818582223e-05 0.000289296852641278 1.55485722485292 0.80952380952381 17.2 17 2 abnormal lysosome morphology 1.56849099165112e-08 5.61384365716857e-07 1.54723537571148 0.805555555555556 17.2 17 2 abnormal physiological neovascularization 3.6445848018238e-05 0.000610498632628734 1.53656478691347 0.8 17.2 17 2 abnormal dendritic cell morphology 0.000378171366599054 0.00453350011766335 1.53656478691347 0.8 17.2 17 2 liver vascular congestion 0.000378171366599054 0.00453350011766335 1.53656478691347 0.8 17.2 17 2 retarded hair growth 0.00411735630192889 0.0322580277198366 1.53656478691347 0.8 17.2 17 2 abnormal airway responsiveness 0.00411735630192889 0.0322580277198366 1.53656478691347 0.8 17.2 17 2 peritoneal inflammation 0.00411735630192889 0.0322580277198366 1.53656478691347 0.8 17.2 17 2 abnormal plasma membrane morphology 0.00411735630192889 0.0322580277198366 1.53656478691347 0.8 17.2 17 2 abnormal gonadal fat pad morphology 0.00411735630192889 0.0322580277198366 1.53656478691347 0.8 17.2 17 2 absent inguinal lymph nodes 0.00411735630192889 0.0322580277198366 1.53656478691347 0.8 17.2 17 2 absent axillary lymph nodes 0.00411735630192889 0.0322580277198366 1.53656478691347 0.8 17.2 17 2 acanthocytosis 0.00411735630192889 0.0322580277198366 1.53656478691347 0.8 17.2 17 2 abnormal left subclavian artery morphology 0.00411735630192889 0.0322580277198366 1.53656478691347 0.8 17.2 17 2 lethality during fetal growth through weaning, complete penetrance 0.00411735630192889 0.0322580277198366 1.53656478691347 0.8 17.2 17 2 abnormal dendritic cell physiology 1.02921080500659e-21 3.02705570100214e-19 1.52579447298651 0.794392523364486 17.2 17 2 abnormal cell cycle 6.33769769926938e-23 2.30424612988453e-20 1.51986299575137 0.791304347826087 17.2 17 2 small superior vagus ganglion 8.59044564519737e-05 0.00128340741996567 1.51634682919093 0.789473684210526 17.2 17 2 abnormal T cell subpopulation ratio 2.03745999794745e-07 5.96256675869915e-06 1.51328350226327 0.787878787878788 17.2 17 2 vascular smooth muscle hypoplasia 0.000893160197046318 0.00931545488533634 1.5091261300043 0.785714285714286 17.2 17 2 multiple persisting craniopharyngeal ducts 0.000893160197046318 0.00931545488533634 1.5091261300043 0.785714285714286 17.2 17 2 increased fatty acid level 4.72079708064054e-07 1.25593398268378e-05 1.50055154972019 0.78125 17.2 17 2 abnormal cell morphology 1.03437079230224e-21 3.02705570100214e-19 1.49949853108881 0.780701754385965 17.2 17 2 absent inner cell mass 0.000200020806604126 0.00259818149570633 1.49388243172143 0.777777777777778 17.2 17 2 abnormal aerobic respiration 0.000200020806604126 0.00259818149570633 1.49388243172143 0.777777777777778 17.2 17 2 heart hyperplasia 0.00976073442209202 0.0619383338646783 1.49388243172143 0.777777777777778 17.2 17 2 abnormal cholinergic neuron morphology 0.00976073442209202 0.0619383338646783 1.49388243172143 0.777777777777778 17.2 17 2 abnormal thymus lobule morphology 0.00976073442209202 0.0619383338646783 1.49388243172143 0.777777777777778 17.2 17 2 abnormal thymus physiology 0.00976073442209202 0.0619383338646783 1.49388243172143 0.777777777777778 17.2 17 2 decreased cellular sensitivity to ionizing radiation 0.00976073442209202 0.0619383338646783 1.49388243172143 0.777777777777778 17.2 17 2 absent cervical lymph nodes 0.00976073442209202 0.0619383338646783 1.49388243172143 0.777777777777778 17.2 17 2 decreased transitional stage T1 B cell number 0.00976073442209202 0.0619383338646783 1.49388243172143 0.777777777777778 17.2 17 2 axonal spheroids 0.00976073442209202 0.0619383338646783 1.49388243172143 0.777777777777778 17.2 17 2 abnormal telomere morphology 0.00976073442209202 0.0619383338646783 1.49388243172143 0.777777777777778 17.2 17 2 osteopetrosis 1.08505300366135e-06 2.67234588773031e-05 1.48699818088401 0.774193548387097 17.2 17 2 embryonic lethality before implantation, incomplete penetrance 4.56876782236798e-05 0.000750152472484511 1.48418189645051 0.772727272727273 17.2 17 2 impaired macrophage chemotaxis 6.09548445169821e-08 1.94391250943581e-06 1.47746614126296 0.769230769230769 17.2 17 2 increased foot pad pigmentation 0.002075507606692 0.0187398372836528 1.47746614126296 0.769230769230769 17.2 17 2 abnormal grip strength 0.002075507606692 0.0187398372836528 1.47746614126296 0.769230769230769 17.2 17 2 abnormal telomere length 0.002075507606692 0.0187398372836528 1.47746614126296 0.769230769230769 17.2 17 2 abnormal fat pad morphology 2.47258415357649e-06 5.541038812632e-05 1.47254125412541 0.766666666666667 17.2 17 2 abnormal cell nucleus morphology 3.47985449340326e-09 1.45481311804044e-07 1.47117905130013 0.765957446808511 17.2 17 2 abnormal bone marrow cavity morphology 0.000459407145911642 0.00536514213828737 1.46877516396141 0.764705882352941 17.2 17 2 increased regulatory T cell number 0.000459407145911642 0.00536514213828737 1.46877516396141 0.764705882352941 17.2 17 2 increased B cell proliferation 4.84034926387816e-11 2.93667531558462e-09 1.46494524176073 0.76271186440678 17.2 17 2 abnormal tumor vascularization 0.000104133419730288 0.00151924857231138 1.46339503515569 0.761904761904762 17.2 17 2 increased B cell derived lymphoma incidence 1.87697556080172e-09 8.11995949129441e-08 1.4597365475678 0.76 17.2 17 2 decreased B cell proliferation 4.01655953050131e-14 3.91811444396942e-12 1.45876403820899 0.759493670886076 17.2 17 2 pale liver 3.69824795430346e-13 3.17220406425168e-11 1.4535072308641 0.756756756756757 17.2 17 2 decreased susceptibility to induced arthritis 2.41878819279723e-10 1.33705236212958e-08 1.44895363678244 0.754385964912281 17.2 17 2 abnormal osteoclast physiology 3.11535837299664e-11 1.91344542045164e-09 1.44052948773138 0.75 17.2 17 2 abnormal myelopoiesis 3.89582984253486e-08 1.29583216424391e-06 1.44052948773138 0.75 17.2 17 2 increased fibroblast apoptosis 2.92397289045326e-06 6.46522894666887e-05 1.44052948773138 0.75 17.2 17 2 decreased liver cholesterol level 0.00103905015856911 0.0107246359727829 1.44052948773138 0.75 17.2 17 2 schistocytosis 0.0225837949078965 0.113842183727347 1.44052948773138 0.75 17.2 17 2 abnormal vagus ganglion morphology 0.0225837949078965 0.113842183727347 1.44052948773138 0.75 17.2 17 2 increased sensitivity to skin irradiation 0.0225837949078965 0.113842183727347 1.44052948773138 0.75 17.2 17 2 short ureter 0.0225837949078965 0.113842183727347 1.44052948773138 0.75 17.2 17 2 loss of GABAergic neurons 0.0225837949078965 0.113842183727347 1.44052948773138 0.75 17.2 17 2 increased cardiac output 0.0225837949078965 0.113842183727347 1.44052948773138 0.75 17.2 17 2 binucleate 0.0225837949078965 0.113842183727347 1.44052948773138 0.75 17.2 17 2 lymph node inflammation 0.0225837949078965 0.113842183727347 1.44052948773138 0.75 17.2 17 2 abnormal extraembryonic tissue physiology 0.0225837949078965 0.113842183727347 1.44052948773138 0.75 17.2 17 2 absent interparietal bone 0.0225837949078965 0.113842183727347 1.44052948773138 0.75 17.2 17 2 abnormal kidney epithelium morphology 0.0225837949078965 0.113842183727347 1.44052948773138 0.75 17.2 17 2 abnormal NK cell morphology 0.0225837949078965 0.113842183727347 1.44052948773138 0.75 17.2 17 2 abnormal epidermal lamellar body morphology 0.0225837949078965 0.113842183727347 1.44052948773138 0.75 17.2 17 2 abnormal olfactory bulb mitral cell layer morphology 0.0225837949078965 0.113842183727347 1.44052948773138 0.75 17.2 17 2 abnormal circulating serum amyloid protein level 0.0225837949078965 0.113842183727347 1.44052948773138 0.75 17.2 17 2 decreased alveolar lamellar body number 0.0225837949078965 0.113842183727347 1.44052948773138 0.75 17.2 17 2 abnormal maxillary prominence morphology 0.0225837949078965 0.113842183727347 1.44052948773138 0.75 17.2 17 2 abnormal foramen magnum morphology 0.0225837949078965 0.113842183727347 1.44052948773138 0.75 17.2 17 2 increased circulating ferritin level 0.0225837949078965 0.113842183727347 1.44052948773138 0.75 17.2 17 2 increased cornea thickness 0.0225837949078965 0.113842183727347 1.44052948773138 0.75 17.2 17 2 abnormal umbilical vein topology 0.0225837949078965 0.113842183727347 1.44052948773138 0.75 17.2 17 2 decreased metastatic potential 5.37468610838374e-05 0.000868151408740555 1.44052948773138 0.75 17.2 17 2 decreased myocardial infarction size 0.000234280281753182 0.00299625810211332 1.44052948773138 0.75 17.2 17 2 abnormal thymocyte activation 0.000234280281753182 0.00299625810211332 1.44052948773138 0.75 17.2 17 2 amyloidosis 0.00473292505711516 0.0351437345658924 1.44052948773138 0.75 17.2 17 2 interstitial pneumonia 0.00473292505711516 0.0351437345658924 1.44052948773138 0.75 17.2 17 2 abnormal embryonic growth/weight/body size 0.00473292505711516 0.0351437345658924 1.44052948773138 0.75 17.2 17 2 altered tumor susceptibility 0.00473292505711516 0.0351437345658924 1.44052948773138 0.75 17.2 17 2 increased growth rate 0.00473292505711516 0.0351437345658924 1.44052948773138 0.75 17.2 17 2 absent ovary 0.00473292505711516 0.0351437345658924 1.44052948773138 0.75 17.2 17 2 abnormal defecation 0.00473292505711516 0.0351437345658924 1.44052948773138 0.75 17.2 17 2 abnormal rostral-caudal body axis extension 0.00473292505711516 0.0351437345658924 1.44052948773138 0.75 17.2 17 2 abnormal pulmonary valve cusp morphology 0.00473292505711516 0.0351437345658924 1.44052948773138 0.75 17.2 17 2 abnormal response to infection 2.35535671330382e-13 2.05577186819061e-11 1.43445130423884 0.746835443037975 17.2 17 2 impaired macrophage phagocytosis 8.59642726958929e-08 2.70678643457005e-06 1.42936259247765 0.744186046511628 17.2 17 2 decreased B-1 B cell number 3.61069320297315e-07 9.76260798086492e-06 1.42821726988752 0.743589743589744 17.2 17 2 inner cell mass degeneration 6.46173620958248e-06 0.000130679421311678 1.42503992334717 0.741935483870968 17.2 17 2 abnormal apoptosis 2.59233752646133e-09 1.10656002834799e-07 1.42274517306803 0.740740740740741 17.2 17 2 abnormal brown adipose tissue morphology 3.33381240228098e-06 7.33881269971144e-05 1.41228381150135 0.735294117647059 17.2 17 2 macrocytosis 0.0023093794807763 0.0202988744114171 1.40851772133735 0.733333333333333 17.2 17 2 decreased hepatocyte number 0.0023093794807763 0.0202988744114171 1.40851772133735 0.733333333333333 17.2 17 2 delayed intramembranous bone ossification 0.0023093794807763 0.0202988744114171 1.40851772133735 0.733333333333333 17.2 17 2 abnormal placenta size 0.0023093794807763 0.0202988744114171 1.40851772133735 0.733333333333333 17.2 17 2 abnormal trophectoderm morphology 0.0023093794807763 0.0202988744114171 1.40851772133735 0.733333333333333 17.2 17 2 immune system phenotype 0.0023093794807763 0.0202988744114171 1.40851772133735 0.733333333333333 17.2 17 2 abnormal microglial cell activation 0.0023093794807763 0.0202988744114171 1.40851772133735 0.733333333333333 17.2 17 2 heterochrony 0.0023093794807763 0.0202988744114171 1.40851772133735 0.733333333333333 17.2 17 2 spleen hyperplasia 5.32354476882959e-12 3.62803222259277e-10 1.40851772133735 0.733333333333333 17.2 17 2 small liver 2.7928836578226e-12 2.07382032801007e-10 1.40359283419981 0.730769230769231 17.2 17 2 abnormal placenta vasculature 1.22252220274564e-08 4.47209408724969e-07 1.40359283419981 0.730769230769231 17.2 17 2 abnormal leukocyte cell number 6.03497852801123e-05 0.000944151514995468 1.40359283419981 0.730769230769231 17.2 17 2 increased leukemia incidence 6.03497852801123e-05 0.000944151514995468 1.40359283419981 0.730769230769231 17.2 17 2 decreased bone resorption 6.03497852801123e-05 0.000944151514995468 1.40359283419981 0.730769230769231 17.2 17 2 decreased Peyer's patch number 6.03497852801123e-05 0.000944151514995468 1.40359283419981 0.730769230769231 17.2 17 2 increased thymocyte apoptosis 6.03497852801123e-05 0.000944151514995468 1.40359283419981 0.730769230769231 17.2 17 2 increased circulating phosphate level 1.71592301681906e-06 4.02675330597869e-05 1.40159625833324 0.72972972972973 17.2 17 2 decreased susceptibility to viral infection induced morbidity/mortality 0.000259988730414578 0.00328285262388966 1.39687707901225 0.727272727272727 17.2 17 2 increased bone volume 0.000259988730414578 0.00328285262388966 1.39687707901225 0.727272727272727 17.2 17 2 abnormal sphenoid bone morphology 0.0105560279634702 0.065481594910554 1.39687707901225 0.727272727272727 17.2 17 2 abnormal thrombopoiesis 0.0105560279634702 0.065481594910554 1.39687707901225 0.727272727272727 17.2 17 2 delayed hepatic development 0.0105560279634702 0.065481594910554 1.39687707901225 0.727272727272727 17.2 17 2 abnormal food preference 0.0105560279634702 0.065481594910554 1.39687707901225 0.727272727272727 17.2 17 2 abnormal hemoglobin 0.0105560279634702 0.065481594910554 1.39687707901225 0.727272727272727 17.2 17 2 abnormal proximal-distal axis patterning 0.0105560279634702 0.065481594910554 1.39687707901225 0.727272727272727 17.2 17 2 increased number of Howell-Jolly bodies 0.0105560279634702 0.065481594910554 1.39687707901225 0.727272727272727 17.2 17 2 chylous ascites 0.0105560279634702 0.065481594910554 1.39687707901225 0.727272727272727 17.2 17 2 hypolactation 0.0105560279634702 0.065481594910554 1.39687707901225 0.727272727272727 17.2 17 2 thin hypoglossal nerve 0.0105560279634702 0.065481594910554 1.39687707901225 0.727272727272727 17.2 17 2 decreased bone marrow cell number 2.46213086978839e-11 1.53113763464966e-09 1.39448516620572 0.726027397260274 17.2 17 2 impaired hematopoiesis 2.62875288182845e-08 9.0193417842045e-07 1.39345336068134 0.725490196078431 17.2 17 2 abnormal B cell differentiation 9.769782341586e-14 9.17069191497931e-12 1.39303950461936 0.725274725274725 17.2 17 2 thrombocytopenia 6.45660272452953e-21 1.69061045023865e-18 1.39085605711995 0.724137931034483 17.2 17 2 abnormal CD8-positive, alpha-beta T cell physiology 3.05868051628326e-05 0.000533927563807342 1.39085605711995 0.724137931034483 17.2 17 2 abnormal erythropoiesis 1.60141347757719e-15 2.09658738182803e-13 1.3902252833979 0.723809523809524 17.2 17 2 increased cellular sensitivity to gamma-irradiation 1.0897360455407e-07 3.34656594232406e-06 1.38944688178346 0.723404255319149 17.2 17 2 abnormal megakaryocyte differentiation 0.00113381162811118 0.0113040337672407 1.38717654374133 0.722222222222222 17.2 17 2 abnormal thymus medulla morphology 0.00113381162811118 0.0113040337672407 1.38717654374133 0.722222222222222 17.2 17 2 darkened coat color 0.00113381162811118 0.0113040337672407 1.38717654374133 0.722222222222222 17.2 17 2 abnormal macrophage chemotaxis 0.00113381162811118 0.0113040337672407 1.38717654374133 0.722222222222222 17.2 17 2 primary atelectasis 0.00113381162811118 0.0113040337672407 1.38717654374133 0.722222222222222 17.2 17 2 increased adipocyte glucose uptake 0.00113381162811118 0.0113040337672407 1.38717654374133 0.722222222222222 17.2 17 2 abnormal vasculogenesis 4.52587066033906e-07 1.2105487384509e-05 1.38469501146272 0.720930232558139 17.2 17 2 abnormal embryonic hematopoiesis 1.55026869140239e-05 0.000291719056578817 1.38050742574257 0.71875 17.2 17 2 abnormal myelin sheath morphology 2.32125255970531e-07 6.65881432286182e-06 1.3778977708735 0.717391304347826 17.2 17 2 abnormal cytotoxic T cell physiology 9.61288657134637e-07 2.39120553462241e-05 1.37193284545846 0.714285714285714 17.2 17 2 increased circulating serum albumin level 7.86016987860051e-06 0.000155794203769074 1.37193284545846 0.714285714285714 17.2 17 2 premature aging 6.54114126330751e-05 0.00101062663928431 1.37193284545846 0.714285714285714 17.2 17 2 increased bone resorption 6.54114126330751e-05 0.00101062663928431 1.37193284545846 0.714285714285714 17.2 17 2 liver degeneration 0.000559647436810414 0.00622873825085416 1.37193284545846 0.714285714285714 17.2 17 2 abnormal erythrocyte physiology 0.000559647436810414 0.00622873825085416 1.37193284545846 0.714285714285714 17.2 17 2 abnormal embryonic/fetal subventricular zone morphology 0.000559647436810414 0.00622873825085416 1.37193284545846 0.714285714285714 17.2 17 2 abnormal antigen presentation 0.00503137613080621 0.0363354284728282 1.37193284545846 0.714285714285714 17.2 17 2 absent olfactory bulb 0.00503137613080621 0.0363354284728282 1.37193284545846 0.714285714285714 17.2 17 2 decreased response to antigen 0.00503137613080621 0.0363354284728282 1.37193284545846 0.714285714285714 17.2 17 2 cellular necrosis 0.0506785571453992 0.199151518008184 1.37193284545846 0.714285714285714 17.2 17 2 mottled coat 0.0506785571453992 0.199151518008184 1.37193284545846 0.714285714285714 17.2 17 2 retina hyperplasia 0.0506785571453992 0.199151518008184 1.37193284545846 0.714285714285714 17.2 17 2 abnormal circulating alanine transaminase level 0.0506785571453992 0.199151518008184 1.37193284545846 0.714285714285714 17.2 17 2 absent amniotic folds 0.0506785571453992 0.199151518008184 1.37193284545846 0.714285714285714 17.2 17 2 decreased activated T cell number 0.0506785571453992 0.199151518008184 1.37193284545846 0.714285714285714 17.2 17 2 increased colonic adenoma incidence 0.0506785571453992 0.199151518008184 1.37193284545846 0.714285714285714 17.2 17 2 abnormal hypersensitivity reaction 0.0506785571453992 0.199151518008184 1.37193284545846 0.714285714285714 17.2 17 2 abnormal lymph node primary follicle morphology 0.0506785571453992 0.199151518008184 1.37193284545846 0.714285714285714 17.2 17 2 detached tectorial membrane 0.0506785571453992 0.199151518008184 1.37193284545846 0.714285714285714 17.2 17 2 decreased cholesterol efflux 0.0506785571453992 0.199151518008184 1.37193284545846 0.714285714285714 17.2 17 2 increased muscle weight 0.0506785571453992 0.199151518008184 1.37193284545846 0.714285714285714 17.2 17 2 abnormal optic tract morphology 0.0506785571453992 0.199151518008184 1.37193284545846 0.714285714285714 17.2 17 2 increased chronic myelocytic leukemia incidence 0.0506785571453992 0.199151518008184 1.37193284545846 0.714285714285714 17.2 17 2 abnormal body temperature 0.0506785571453992 0.199151518008184 1.37193284545846 0.714285714285714 17.2 17 2 decreased tidal volume 0.0506785571453992 0.199151518008184 1.37193284545846 0.714285714285714 17.2 17 2 abnormal uterus physiology 0.0506785571453992 0.199151518008184 1.37193284545846 0.714285714285714 17.2 17 2 abnormal prostaglandin level 0.0506785571453992 0.199151518008184 1.37193284545846 0.714285714285714 17.2 17 2 increased tumor latency 0.0506785571453992 0.199151518008184 1.37193284545846 0.714285714285714 17.2 17 2 abnormal sperm annulus morphology 0.0506785571453992 0.199151518008184 1.37193284545846 0.714285714285714 17.2 17 2 decreased T-helper 17 cell number 0.0506785571453992 0.199151518008184 1.37193284545846 0.714285714285714 17.2 17 2 abnormal conotruncal ridge morphology 0.0506785571453992 0.199151518008184 1.37193284545846 0.714285714285714 17.2 17 2 abnormal aortic valve cusp morphology 0.0506785571453992 0.199151518008184 1.37193284545846 0.714285714285714 17.2 17 2 increased compact bone volume 0.0506785571453992 0.199151518008184 1.37193284545846 0.714285714285714 17.2 17 2 embryonic lethality at implantation, incomplete penetrance 0.0506785571453992 0.199151518008184 1.37193284545846 0.714285714285714 17.2 17 2 increased circulating lactate dehydrogenase level 0.0506785571453992 0.199151518008184 1.37193284545846 0.714285714285714 17.2 17 2 parturition failure 0.0506785571453992 0.199151518008184 1.37193284545846 0.714285714285714 17.2 17 2 decreased areal bone mineral density 0.0506785571453992 0.199151518008184 1.37193284545846 0.714285714285714 17.2 17 2 gliosis 1.86721378916917e-09 8.11995949129441e-08 1.37193284545846 0.714285714285714 17.2 17 2 trabecula carnea hypoplasia 4.90525580923261e-07 1.29806636441129e-05 1.36583536614531 0.711111111111111 17.2 17 2 abnormal capillary morphology 3.28936297855017e-05 0.000564295890285761 1.36308166581034 0.709677419354839 17.2 17 2 abnormal CD8-positive, alpha beta T cell morphology 3.28936297855017e-05 0.000564295890285761 1.36308166581034 0.709677419354839 17.2 17 2 abnormal mitochondrial ATP synthesis coupled electron transport 3.28936297855017e-05 0.000564295890285761 1.36308166581034 0.709677419354839 17.2 17 2 abnormal tumor morphology 0.000277496541628988 0.00345797163209738 1.3605000717463 0.708333333333333 17.2 17 2 abnormal direction of heart looping 1.65680678480982e-05 0.000307560214717495 1.3557924590413 0.705882352941177 17.2 17 2 hyperlipidemia 0.00243019338894704 0.0208967929248826 1.3557924590413 0.705882352941177 17.2 17 2 abnormal dorsal-ventral axis patterning 0.00243019338894704 0.0208967929248826 1.3557924590413 0.705882352941177 17.2 17 2 abnormal ectoplacental cone morphology 0.00243019338894704 0.0208967929248826 1.3557924590413 0.705882352941177 17.2 17 2 abnormal circulating chemokine level 0.00243019338894704 0.0208967929248826 1.3557924590413 0.705882352941177 17.2 17 2 increased hepatoma incidence 0.00243019338894704 0.0208967929248826 1.3557924590413 0.705882352941177 17.2 17 2 increased trabecular bone mass 0.00243019338894704 0.0208967929248826 1.3557924590413 0.705882352941177 17.2 17 2 increased inflammatory response 5.66647495702913e-13 4.77808693410507e-11 1.35460316741056 0.705263157894737 17.2 17 2 decreased circulating fructosamine level 0.000138122131526988 0.001908155556684 1.35160791441463 0.703703703703704 17.2 17 2 neuron degeneration 5.2241129145219e-07 1.37513025130934e-05 1.34858079702512 0.702127659574468 17.2 17 2 abnormal spleen marginal zone morphology 6.89731564270517e-05 0.00105581985607564 1.34449418854929 0.7 17.2 17 2 abnormal microglial cell physiology 6.89731564270517e-05 0.00105581985607564 1.34449418854929 0.7 17.2 17 2 abnormal brain vasculature morphology 6.89731564270517e-05 0.00105581985607564 1.34449418854929 0.7 17.2 17 2 oxidative stress 4.72145862436614e-12 3.26239675780855e-10 1.34449418854929 0.7 17.2 17 2 abnormal Peyer's patch T cell area morphology 0.00118516796600975 0.0115120892182566 1.34449418854929 0.7 17.2 17 2 abnormal neuron proliferation 0.00118516796600975 0.0115120892182566 1.34449418854929 0.7 17.2 17 2 increased skin tumor incidence 0.00118516796600975 0.0115120892182566 1.34449418854929 0.7 17.2 17 2 increased cranium width 0.0229286167024727 0.113842183727347 1.34449418854929 0.7 17.2 17 2 abnormal mammary gland physiology 0.0229286167024727 0.113842183727347 1.34449418854929 0.7 17.2 17 2 abnormal respiratory mechanics 0.0229286167024727 0.113842183727347 1.34449418854929 0.7 17.2 17 2 acrania 0.0229286167024727 0.113842183727347 1.34449418854929 0.7 17.2 17 2 absent CD4-positive, alpha beta T cells 0.0229286167024727 0.113842183727347 1.34449418854929 0.7 17.2 17 2 absent pharyngeal arches 0.0229286167024727 0.113842183727347 1.34449418854929 0.7 17.2 17 2 increased heart rate variability 0.0229286167024727 0.113842183727347 1.34449418854929 0.7 17.2 17 2 abnormal gas homeostasis 0.0229286167024727 0.113842183727347 1.34449418854929 0.7 17.2 17 2 abnormal embryonic erythrocyte morphology 0.0229286167024727 0.113842183727347 1.34449418854929 0.7 17.2 17 2 abnormal corneal endothelium morphology 0.0229286167024727 0.113842183727347 1.34449418854929 0.7 17.2 17 2 osteosclerosis 0.0229286167024727 0.113842183727347 1.34449418854929 0.7 17.2 17 2 increased platelet aggregation 0.0229286167024727 0.113842183727347 1.34449418854929 0.7 17.2 17 2 increased kidney iron level 0.0229286167024727 0.113842183727347 1.34449418854929 0.7 17.2 17 2 thick aortic valve cusps 0.0229286167024727 0.113842183727347 1.34449418854929 0.7 17.2 17 2 increased compact bone area 0.0229286167024727 0.113842183727347 1.34449418854929 0.7 17.2 17 2 abnormal adaptive thermogenesis 0.0229286167024727 0.113842183727347 1.34449418854929 0.7 17.2 17 2 decreased circulating lactate level 0.0229286167024727 0.113842183727347 1.34449418854929 0.7 17.2 17 2 extramedullary hematopoiesis 8.24239372115084e-14 7.8857516851395e-12 1.34087021499525 0.69811320754717 17.2 17 2 abnormal homeostasis 2.13521540582865e-06 4.91791511296183e-05 1.3400274304478 0.697674418604651 17.2 17 2 abnormal double-strand DNA break repair 2.13521540582865e-06 4.91791511296183e-05 1.3400274304478 0.697674418604651 17.2 17 2 decreased cell proliferation 6.48431071726301e-23 2.30424612988453e-20 1.3393030912962 0.697297297297297 17.2 17 2 increased osteoblast cell number 3.45385137247442e-05 0.000588773209010017 1.33867386738674 0.696969696969697 17.2 17 2 decreased T cell proliferation 1.6968234540234e-18 3.517373618236e-16 1.33670754266966 0.695945945945946 17.2 17 2 abnormal cell death 1.08115489510094e-06 2.67234588773031e-05 1.33614329296824 0.695652173913043 17.2 17 2 increased susceptibility to fungal infection 0.000582232263759503 0.00639427265387092 1.33614329296824 0.695652173913043 17.2 17 2 abnormal inflammatory response 1.15987171751644e-09 5.34292758763359e-08 1.33382359975128 0.694444444444444 17.2 17 2 increased susceptibility to bacterial infection induced morbidity/mortality 1.15987171751644e-09 5.34292758763359e-08 1.33382359975128 0.694444444444444 17.2 17 2 increased T cell derived lymphoma incidence 5.48004265952138e-07 1.41927578225361e-05 1.33273476415965 0.693877551020408 17.2 17 2 increased autoantibody level 8.72035293182309e-06 0.000170132375826745 1.32971952713666 0.692307692307692 17.2 17 2 pulmonary edema 0.000287678145466072 0.00354257122201413 1.32971952713666 0.692307692307692 17.2 17 2 abnormal tail bud morphology 0.0107121143205673 0.0660381273170042 1.32971952713666 0.692307692307692 17.2 17 2 small otic vesicle 0.0107121143205673 0.0660381273170042 1.32971952713666 0.692307692307692 17.2 17 2 abnormal exocrine pancreas morphology 0.0107121143205673 0.0660381273170042 1.32971952713666 0.692307692307692 17.2 17 2 orthokeratosis 0.0107121143205673 0.0660381273170042 1.32971952713666 0.692307692307692 17.2 17 2 increased prostaglandin level 0.0107121143205673 0.0660381273170042 1.32971952713666 0.692307692307692 17.2 17 2 decreased circulating total protein level 1.41177849605968e-07 4.2310831433114e-06 1.32703322506164 0.690909090909091 17.2 17 2 thrombocytosis 7.17436635598595e-08 2.27340589942867e-06 1.32462481630472 0.689655172413793 17.2 17 2 decreased granulocyte number 0.000142799429233613 0.00194637578201979 1.32462481630472 0.689655172413793 17.2 17 2 abnormal myocardial trabeculae morphology 2.21790218097727e-06 5.06149694970731e-05 1.32315301095327 0.688888888888889 17.2 17 2 abnormal cell migration 2.21790218097727e-06 5.06149694970731e-05 1.32315301095327 0.688888888888889 17.2 17 2 enlarged spleen 4.70442039561416e-33 2.92556143352255e-30 1.32048536375377 0.6875 17.2 17 2 decreased lymphocyte cell number 1.66460785103794e-15 2.12344206638814e-13 1.32048536375377 0.6875 17.2 17 2 decreased mast cell number 0.00510410398963209 0.0365365717243448 1.32048536375377 0.6875 17.2 17 2 disorganized yolk sac vascular plexus 0.00510410398963209 0.0365365717243448 1.32048536375377 0.6875 17.2 17 2 sepsis 0.00510410398963209 0.0365365717243448 1.32048536375377 0.6875 17.2 17 2 blepharitis 0.00510410398963209 0.0365365717243448 1.32048536375377 0.6875 17.2 17 2 impaired somite development 0.00510410398963209 0.0365365717243448 1.32048536375377 0.6875 17.2 17 2 abnormal osteoclast morphology 1.12100931089504e-06 2.74730114369597e-05 1.32048536375377 0.6875 17.2 17 2 decreased embryo size 1.24431318586349e-53 2.06348603322361e-50 1.31797398040695 0.686192468619247 17.2 17 2 decreased leukocyte cell number 2.24941424791213e-16 3.60994705914931e-14 1.317856660309 0.686131386861314 17.2 17 2 decreased tumor growth/size 2.87426164082688e-07 8.03339981073804e-06 1.31603928508793 0.685185185185185 17.2 17 2 altered susceptibility to infection 0.00246471921712008 0.0209965378513226 1.31416725196547 0.684210526315789 17.2 17 2 decreased tumor incidence 0.00246471921712008 0.0209965378513226 1.31416725196547 0.684210526315789 17.2 17 2 abnormal blastocyst morphology 0.00246471921712008 0.0209965378513226 1.31416725196547 0.684210526315789 17.2 17 2 absent amnion 0.00246471921712008 0.0209965378513226 1.31416725196547 0.684210526315789 17.2 17 2 lung inflammation 4.5404356679125e-16 6.84505074177718e-14 1.31342394469626 0.683823529411765 17.2 17 2 increased leukocyte cell number 6.12450649418123e-17 1.08819356459113e-14 1.31137856814167 0.682758620689655 17.2 17 2 increased T cell proliferation 7.55611765485262e-13 6.2652808888153e-11 1.31038819444724 0.682242990654206 17.2 17 2 muscular atrophy 4.50796634487568e-06 9.38914050742985e-05 1.30957226157398 0.681818181818182 17.2 17 2 abnormal germ layer development 0.00120177323623007 0.0115421271240243 1.30957226157398 0.681818181818182 17.2 17 2 increased myocardial infarction size 0.00120177323623007 0.0115421271240243 1.30957226157398 0.681818181818182 17.2 17 2 aphakia 0.00120177323623007 0.0115421271240243 1.30957226157398 0.681818181818182 17.2 17 2 abnormal thyroid gland morphology 0.000590295624902604 0.00642608475687189 1.30608006887645 0.68 17.2 17 2 decreased acute inflammation 0.000590295624902604 0.00642608475687189 1.30608006887645 0.68 17.2 17 2 lymphoid hyperplasia 0.000291622538080803 0.00355593658566666 1.30333620318554 0.678571428571429 17.2 17 2 abnormal brainstem morphology 0.000291622538080803 0.00355593658566666 1.30333620318554 0.678571428571429 17.2 17 2 abnormal mitotic spindle morphology 0.000291622538080803 0.00355593658566666 1.30333620318554 0.678571428571429 17.2 17 2 increased tumor incidence 2.72506990827671e-14 2.8244214153493e-12 1.30112340827351 0.67741935483871 17.2 17 2 decreased cytotoxic T cell cytolysis 7.21130823759132e-05 0.0010871593479399 1.29930110658125 0.676470588235294 17.2 17 2 increased granulocyte number 5.0479883420277e-09 2.0253017743216e-07 1.29777431327152 0.675675675675676 17.2 17 2 abnormal T cell activation 5.0479883420277e-09 2.0253017743216e-07 1.29777431327152 0.675675675675676 17.2 17 2 increased trabecular bone volume 3.60432124810607e-05 0.000605793858423233 1.29777431327152 0.675675675675676 17.2 17 2 abnormal cytokine secretion 3.38644514765199e-17 6.4798325421418e-15 1.29710014479709 0.675324675324675 17.2 17 2 decreased neutrophil cell number 2.07405415120516e-13 1.84257489325815e-11 1.29688694621971 0.675213675213675 17.2 17 2 abnormal immune system morphology 4.56717990512165e-06 9.38914050742985e-05 1.29438881506298 0.673913043478261 17.2 17 2 abnormal allantois morphology 4.56717990512165e-06 9.38914050742985e-05 1.29438881506298 0.673913043478261 17.2 17 2 abnormal lymphocyte physiology 4.56717990512165e-06 9.38914050742985e-05 1.29438881506298 0.673913043478261 17.2 17 2 embryonic lethality between implantation and placentation, complete penetrance 4.56717990512165e-06 9.38914050742985e-05 1.29438881506298 0.673913043478261 17.2 17 2 distended pericardium 1.16290118080667e-06 2.83599675221235e-05 1.29278287360509 0.673076923076923 17.2 17 2 abnormal platelet physiology 5.88047699395944e-07 1.50596128409343e-05 1.29211129808633 0.672727272727273 17.2 17 2 abnormal embryonic neuroepithelium morphology 2.9771877176043e-07 8.26311456305321e-06 1.2915091958971 0.672413793103448 17.2 17 2 embryonic lethality between somite formation and embryo turning, complete penetrance 1.97520420953677e-08 6.87177688282896e-07 1.28961687473095 0.671428571428571 17.2 17 2 astrocytosis 1.00443992526874e-08 3.75720949489623e-07 1.2892410027185 0.671232876712329 17.2 17 2 abnormal placenta morphology 2.60236227772292e-09 1.10656002834799e-07 1.28857490041794 0.670886075949367 17.2 17 2 embryonic lethality between implantation and somite formation, complete penetrance 1.30961967615599e-25 5.92305262625093e-23 1.28569706660107 0.669387755102041 17.2 17 2 increased neutrophil cell number 1.00401354569924e-15 1.42713353995821e-13 1.28488607181558 0.668965517241379 17.2 17 2 anemia 4.06882276197906e-22 1.34949288272305e-19 1.28350494641469 0.66824644549763 17.2 17 2 embryonic lethality, complete penetrance 1.36135469919118e-32 7.52526625386237e-30 1.28247766305866 0.667711598746082 17.2 17 2 decreased birth body size 1.60616626754014e-12 1.21070866378973e-10 1.28047065576123 0.666666666666667 17.2 17 2 abnormal hepatocyte morphology 3.14174777339926e-12 2.26524567719729e-10 1.28047065576123 0.666666666666667 17.2 17 2 abnormal definitive hematopoiesis 1.76937804854213e-10 9.8906244848282e-09 1.28047065576123 0.666666666666667 17.2 17 2 decreased inflammatory response 1.33401019211679e-09 5.97166408484131e-08 1.28047065576123 0.666666666666667 17.2 17 2 increased embryonic tissue cell apoptosis 5.1411817991898e-09 2.04619035607754e-07 1.28047065576123 0.666666666666667 17.2 17 2 increased lymphocyte cell number 3.90703165098666e-08 1.29583216424391e-06 1.28047065576123 0.666666666666667 17.2 17 2 muscular ventricular septal defect 2.98966959065242e-07 8.26311456305321e-06 1.28047065576123 0.666666666666667 17.2 17 2 increased macrophage cell number 5.90276282207476e-07 1.50596128409343e-05 1.28047065576123 0.666666666666667 17.2 17 2 increased lung adenocarcinoma incidence 2.30933383277265e-06 5.22224355365634e-05 1.28047065576123 0.666666666666667 17.2 17 2 failure of chorioallantoic fusion 2.30933383277265e-06 5.22224355365634e-05 1.28047065576123 0.666666666666667 17.2 17 2 abnormal leukocyte adhesion 3.60391599204976e-05 0.000605793858423233 1.28047065576123 0.666666666666667 17.2 17 2 abnormal trophoblast giant cell morphology 7.20278886201636e-05 0.0010871593479399 1.28047065576123 0.666666666666667 17.2 17 2 increased cardiomyocyte apoptosis 0.000144384084858771 0.00196259787478793 1.28047065576123 0.666666666666667 17.2 17 2 arrested T cell differentiation 0.000290451974846738 0.00355593658566666 1.28047065576123 0.666666666666667 17.2 17 2 increased brain weight 0.000586790173344242 0.00641600244480792 1.28047065576123 0.666666666666667 17.2 17 2 abnormal nursing 0.00119170370802053 0.0115120892182566 1.28047065576123 0.666666666666667 17.2 17 2 blindness 0.00119170370802053 0.0115120892182566 1.28047065576123 0.666666666666667 17.2 17 2 increased body temperature 0.00119170370802053 0.0115120892182566 1.28047065576123 0.666666666666667 17.2 17 2 abnormal eye pigmentation 0.00243620902440842 0.0208967929248826 1.28047065576123 0.666666666666667 17.2 17 2 abnormal hematopoietic system physiology 0.00243620902440842 0.0208967929248826 1.28047065576123 0.666666666666667 17.2 17 2 embryonic lethality at implantation, complete penetrance 0.00243620902440842 0.0208967929248826 1.28047065576123 0.666666666666667 17.2 17 2 underdeveloped hair follicles 0.00502295691061876 0.0363354284728282 1.28047065576123 0.666666666666667 17.2 17 2 abnormal mammary gland morphology 0.00502295691061876 0.0363354284728282 1.28047065576123 0.666666666666667 17.2 17 2 abnormal Peyer's patch follicle morphology 0.00502295691061876 0.0363354284728282 1.28047065576123 0.666666666666667 17.2 17 2 abnormal white adipose tissue morphology 0.00502295691061876 0.0363354284728282 1.28047065576123 0.666666666666667 17.2 17 2 abnormal metacarpal bone morphology 0.00502295691061876 0.0363354284728282 1.28047065576123 0.666666666666667 17.2 17 2 abnormal redox activity 0.00502295691061876 0.0363354284728282 1.28047065576123 0.666666666666667 17.2 17 2 decreased cellular sensitivity to gamma-irradiation 0.00502295691061876 0.0363354284728282 1.28047065576123 0.666666666666667 17.2 17 2 abnormal glycogen homeostasis 0.00502295691061876 0.0363354284728282 1.28047065576123 0.666666666666667 17.2 17 2 increased effector memory CD4-positive, alpha-beta T cell number 0.00502295691061876 0.0363354284728282 1.28047065576123 0.666666666666667 17.2 17 2 abnormal hypoglossal nerve topology 0.00502295691061876 0.0363354284728282 1.28047065576123 0.666666666666667 17.2 17 2 joint inflammation 0.010475369430866 0.065481594910554 1.28047065576123 0.666666666666667 17.2 17 2 decreased thymocyte apoptosis 0.010475369430866 0.065481594910554 1.28047065576123 0.666666666666667 17.2 17 2 mesocardia 0.0222022337761802 0.113842183727347 1.28047065576123 0.666666666666667 17.2 17 2 myocarditis 0.0222022337761802 0.113842183727347 1.28047065576123 0.666666666666667 17.2 17 2 increased papilloma incidence 0.0222022337761802 0.113842183727347 1.28047065576123 0.666666666666667 17.2 17 2 increased osteosarcoma incidence 0.0222022337761802 0.113842183727347 1.28047065576123 0.666666666666667 17.2 17 2 pale placenta 0.0222022337761802 0.113842183727347 1.28047065576123 0.666666666666667 17.2 17 2 abnormal B cell proliferation 0.0222022337761802 0.113842183727347 1.28047065576123 0.666666666666667 17.2 17 2 abnormal palatine bone morphology 0.0222022337761802 0.113842183727347 1.28047065576123 0.666666666666667 17.2 17 2 decreased mammary gland epithelial cell proliferation 0.0222022337761802 0.113842183727347 1.28047065576123 0.666666666666667 17.2 17 2 embryonic lethality between implantation and placentation, incomplete penetrance 0.0222022337761802 0.113842183727347 1.28047065576123 0.666666666666667 17.2 17 2 abnormal vitelline vein connection 0.0222022337761802 0.113842183727347 1.28047065576123 0.666666666666667 17.2 17 2 crypts of Lieberkuhn abscesses 0.0482299158795052 0.199151518008184 1.28047065576123 0.666666666666667 17.2 17 2 increased pheochromocytoma incidence 0.0482299158795052 0.199151518008184 1.28047065576123 0.666666666666667 17.2 17 2 polycythemia 0.0482299158795052 0.199151518008184 1.28047065576123 0.666666666666667 17.2 17 2 abnormal artery development 0.0482299158795052 0.199151518008184 1.28047065576123 0.666666666666667 17.2 17 2 decreased fear-related response 0.0482299158795052 0.199151518008184 1.28047065576123 0.666666666666667 17.2 17 2 impaired febrile response 0.0482299158795052 0.199151518008184 1.28047065576123 0.666666666666667 17.2 17 2 liver hyperplasia 0.0482299158795052 0.199151518008184 1.28047065576123 0.666666666666667 17.2 17 2 enhanced conditioned place preference behavior 0.0482299158795052 0.199151518008184 1.28047065576123 0.666666666666667 17.2 17 2 abnormal liver vasculature morphology 0.0482299158795052 0.199151518008184 1.28047065576123 0.666666666666667 17.2 17 2 eye opacity 0.0482299158795052 0.199151518008184 1.28047065576123 0.666666666666667 17.2 17 2 retropulsion 0.0482299158795052 0.199151518008184 1.28047065576123 0.666666666666667 17.2 17 2 abnormal ventricle myocardium morphology 0.0482299158795052 0.199151518008184 1.28047065576123 0.666666666666667 17.2 17 2 shortened ST segment 0.0482299158795052 0.199151518008184 1.28047065576123 0.666666666666667 17.2 17 2 iris coloboma 0.0482299158795052 0.199151518008184 1.28047065576123 0.666666666666667 17.2 17 2 decreased susceptibility to parasitic infection induced morbidity/mortality 0.0482299158795052 0.199151518008184 1.28047065576123 0.666666666666667 17.2 17 2 decreased effector memory CD4-positive, alpha-beta T cell number 0.0482299158795052 0.199151518008184 1.28047065576123 0.666666666666667 17.2 17 2 abnormal oxidative phosphorylation 0.0482299158795052 0.199151518008184 1.28047065576123 0.666666666666667 17.2 17 2 increased core body temperature 0.0482299158795052 0.199151518008184 1.28047065576123 0.666666666666667 17.2 17 2 increased endoplasmic reticulum stress 0.0482299158795052 0.199151518008184 1.28047065576123 0.666666666666667 17.2 17 2 decreased platelet dense granule number 0.0482299158795052 0.199151518008184 1.28047065576123 0.666666666666667 17.2 17 2 decreased erythrocyte cell number 2.67061300845236e-16 4.15196866157829e-14 1.27231479171179 0.662420382165605 17.2 17 2 decreased B cell number 1.17266846940693e-20 2.77810744538071e-18 1.2680389018218 0.660194174757282 17.2 17 2 increased monocyte cell number 9.02166713245333e-11 5.34318975999468e-09 1.26766594920362 0.66 17.2 17 2 decreased double-positive T cell number 9.02166713245333e-11 5.34318975999468e-09 1.26766594920362 0.66 17.2 17 2 decreased IgM level 1.76642776583772e-10 9.8906244848282e-09 1.26726992735132 0.65979381443299 17.2 17 2 decreased hemoglobin content 1.47667859532951e-14 1.59706000255746e-12 1.26684862750845 0.659574468085106 17.2 17 2 thymus hypoplasia 2.88355744560785e-14 2.92769352895899e-12 1.26655249645948 0.659420289855073 17.2 17 2 increased grip strength 6.77864243766338e-10 3.30624962033091e-08 1.26639954965396 0.659340659340659 17.2 17 2 increased T cell number 1.32863541709436e-09 5.97166408484131e-08 1.26591985285485 0.659090909090909 17.2 17 2 embryonic lethality, incomplete penetrance 1.79012640961059e-05 0.000329847366215285 1.26591985285485 0.659090909090909 17.2 17 2 arrested B cell differentiation 3.56293097072598e-05 0.000602910938073529 1.26485515995926 0.658536585365854 17.2 17 2 abnormal cell differentiation 3.56293097072598e-05 0.000602910938073529 1.26485515995926 0.658536585365854 17.2 17 2 liver inflammation 1.60243356612884e-12 1.21070866378973e-10 1.26446477256421 0.658333333333333 17.2 17 2 persistence of hyaloid vascular system 7.10751173907009e-05 0.00107804484456932 1.26362235765911 0.657894736842105 17.2 17 2 decreased neuron apoptosis 7.10751173907009e-05 0.00107804484456932 1.26362235765911 0.657894736842105 17.2 17 2 abnormal liver development 0.000142159514166628 0.00194297687631587 1.26217821782178 0.657142857142857 17.2 17 2 abnormal dermal layer morphology 0.000142159514166628 0.00194297687631587 1.26217821782178 0.657142857142857 17.2 17 2 abnormal midbrain development 0.000142159514166628 0.00194297687631587 1.26217821782178 0.657142857142857 17.2 17 2 neonatal lethality 0.000285223400892725 0.00352105811275759 1.26046330176496 0.65625 17.2 17 2 decreased susceptibility to parasitic infection 0.000285223400892725 0.00352105811275759 1.26046330176496 0.65625 17.2 17 2 bradykinesia 0.000285223400892725 0.00352105811275759 1.26046330176496 0.65625 17.2 17 2 abnormal spleen morphology 3.52368570938801e-17 6.49271718674273e-15 1.25839357548948 0.655172413793103 17.2 17 2 abnormal embryonic erythropoiesis 0.000574386444890465 0.00633608107168528 1.25839357548948 0.655172413793103 17.2 17 2 enlarged epididymis 0.000574386444890465 0.00633608107168528 1.25839357548948 0.655172413793103 17.2 17 2 blood in lymph vessels 0.000574386444890465 0.00633608107168528 1.25839357548948 0.655172413793103 17.2 17 2 abnormal leukocyte migration 4.47481773093064e-06 9.38914050742985e-05 1.25584622007351 0.653846153846154 17.2 17 2 heart inflammation 0.00116190641939383 0.0115120892182566 1.25584622007351 0.653846153846154 17.2 17 2 abnormal nerve conduction 0.00116190641939383 0.0115120892182566 1.25584622007351 0.653846153846154 17.2 17 2 lethality throughout fetal growth and development, complete penetrance 2.38321579333229e-18 4.74259942873126e-16 1.25351337879783 0.652631578947368 17.2 17 2 abnormal vitelline vasculature morphology 1.16992244298937e-11 7.46200532547708e-10 1.25263433715772 0.652173913043478 17.2 17 2 failure to gastrulate 1.756480986183e-05 0.000324851037407452 1.25263433715772 0.652173913043478 17.2 17 2 dilated heart 0.00236341255961237 0.020700664584633 1.25263433715772 0.652173913043478 17.2 17 2 abnormal B cell morphology 0.00236341255961237 0.020700664584633 1.25263433715772 0.652173913043478 17.2 17 2 pale yolk sac 9.75101902442207e-09 3.67509997321968e-07 1.24961594116457 0.650602409638554 17.2 17 2 abnormal neural tube closure 9.75101902442207e-09 3.67509997321968e-07 1.24961594116457 0.650602409638554 17.2 17 2 small gonad 0.00484102868346781 0.0356801743707442 1.2484588893672 0.65 17.2 17 2 increased mammary adenocarcinoma incidence 0.00484102868346781 0.0356801743707442 1.2484588893672 0.65 17.2 17 2 anencephaly 0.00484102868346781 0.0356801743707442 1.2484588893672 0.65 17.2 17 2 absent placental labyrinth 0.00484102868346781 0.0356801743707442 1.2484588893672 0.65 17.2 17 2 dilated vasculature 0.00484102868346781 0.0356801743707442 1.2484588893672 0.65 17.2 17 2 increased B cell number 1.15062490502831e-11 7.43423234092964e-10 1.24763807484427 0.64957264957265 17.2 17 2 abnormal long bone metaphysis morphology 0.000138461136876969 0.001908155556684 1.24586334074065 0.648648648648649 17.2 17 2 increased erythroid progenitor cell number 0.000138461136876969 0.001908155556684 1.24586334074065 0.648648648648649 17.2 17 2 abnormal chromosome morphology 0.000138461136876969 0.001908155556684 1.24586334074065 0.648648648648649 17.2 17 2 skin inflammation 0.000138461136876969 0.001908155556684 1.24586334074065 0.648648648648649 17.2 17 2 embryonic lethality during organogenesis, complete penetrance 5.49829069120373e-50 5.47079923774771e-47 1.24502905725355 0.648214285714286 17.2 17 2 neurodegeneration 4.37404082351918e-06 9.22070046483387e-05 1.24490202643453 0.648148148148148 17.2 17 2 decreased platelet aggregation 4.37404082351918e-06 9.22070046483387e-05 1.24490202643453 0.648148148148148 17.2 17 2 embryonic lethality before implantation, complete penetrance 2.96518686026174e-12 2.16938303379443e-10 1.24461747739991 0.648 17.2 17 2 abnormal extraembryonic tissue morphology 3.26562259060105e-10 1.76592091176524e-08 1.24280975412119 0.647058823529412 17.2 17 2 decreased mean corpuscular hemoglobin 2.83498973026382e-07 8.0136783568537e-06 1.24280975412119 0.647058823529412 17.2 17 2 decreased regulatory T cell number 0.000276880922744009 0.00345797163209738 1.24280975412119 0.647058823529412 17.2 17 2 increased brain size 0.0100062734242214 0.0632543968049573 1.24280975412119 0.647058823529412 17.2 17 2 coloboma 0.0100062734242214 0.0632543968049573 1.24280975412119 0.647058823529412 17.2 17 2 abnormal cell cytoskeleton morphology 0.0100062734242214 0.0632543968049573 1.24280975412119 0.647058823529412 17.2 17 2 decreased circulating serum albumin level 6.37929615413197e-10 3.14227706602045e-08 1.24166851467755 0.646464646464647 17.2 17 2 preweaning lethality, complete penetrance 6.88548938368292e-65 3.42553096838225e-61 1.24067224348757 0.645945945945946 17.2 17 2 abnormal myocardium layer morphology 3.66126929116487e-08 1.23073072456387e-06 1.23994943247764 0.645569620253165 17.2 17 2 pale kidney 0.000555382542978431 0.00622620577329114 1.23916515073667 0.645161290322581 17.2 17 2 abnormal T cell proliferation 0.000555382542978431 0.00622620577329114 1.23916515073667 0.645161290322581 17.2 17 2 abnormal T cell differentiation 6.22276439507395e-10 3.09582528654929e-08 1.23609791026455 0.643564356435644 17.2 17 2 abnormal circulating cholesterol level 0.00111809191681843 0.0113040337672407 1.23473956091261 0.642857142857143 17.2 17 2 straub tail 0.00111809191681843 0.0113040337672407 1.23473956091261 0.642857142857143 17.2 17 2 increased triglyceride level 0.00111809191681843 0.0113040337672407 1.23473956091261 0.642857142857143 17.2 17 2 abnormal blood flow velocity 0.0209374430621373 0.110017294359064 1.23473956091261 0.642857142857143 17.2 17 2 abnormal adrenal gland secretion 0.0209374430621373 0.110017294359064 1.23473956091261 0.642857142857143 17.2 17 2 abnormal spleen periarteriolar lymphoid sheath morphology 0.0209374430621373 0.110017294359064 1.23473956091261 0.642857142857143 17.2 17 2 increased lactate dehydrogenase level 0.0209374430621373 0.110017294359064 1.23473956091261 0.642857142857143 17.2 17 2 amyloid beta deposits 0.0209374430621373 0.110017294359064 1.23473956091261 0.642857142857143 17.2 17 2 failure of zygotic cell division 0.0209374430621373 0.110017294359064 1.23473956091261 0.642857142857143 17.2 17 2 abnormal maternal decidual layer morphology 0.0209374430621373 0.110017294359064 1.23473956091261 0.642857142857143 17.2 17 2 abnormal positive T cell selection 0.0209374430621373 0.110017294359064 1.23473956091261 0.642857142857143 17.2 17 2 increased B-1 B cell number 0.0209374430621373 0.110017294359064 1.23473956091261 0.642857142857143 17.2 17 2 abnormal glucose tolerance 0.0209374430621373 0.110017294359064 1.23473956091261 0.642857142857143 17.2 17 2 increased stomach tumor incidence 0.0209374430621373 0.110017294359064 1.23473956091261 0.642857142857143 17.2 17 2 pulmonary alveolar hemorrhage 0.0209374430621373 0.110017294359064 1.23473956091261 0.642857142857143 17.2 17 2 testis degeneration 0.0209374430621373 0.110017294359064 1.23473956091261 0.642857142857143 17.2 17 2 embryonic growth arrest 1.87487482927224e-20 4.23977376164972e-18 1.23294226897533 0.641921397379913 17.2 17 2 internal hemorrhage 5.41119540621172e-07 1.40946058355515e-05 1.23269189994924 0.641791044776119 17.2 17 2 decreased white adipose tissue amount 5.41119540621172e-07 1.40946058355515e-05 1.23269189994924 0.641791044776119 17.2 17 2 increased hepatocyte apoptosis 0.000133639327158922 0.00186757205790909 1.2312217843858 0.641025641025641 17.2 17 2 abnormal interventricular septum morphology 1.65289340195905e-05 0.000307560214717495 1.22925182953078 0.64 17.2 17 2 abnormal brain morphology 1.23733241921798e-14 1.3990292694567e-12 1.22877463549758 0.639751552795031 17.2 17 2 abnormal pharyngeal arch morphology 0.000266238543979604 0.00335325761088235 1.22711771177118 0.638888888888889 17.2 17 2 increased circulating HDL cholesterol level 5.86237804602475e-10 2.94599300797709e-08 1.22559334194289 0.638095238095238 17.2 17 2 increased spleen weight 1.49642824169135e-10 8.65666337490052e-09 1.22381266214347 0.63716814159292 17.2 17 2 abnormal embryo turning 8.06778696022946e-06 0.00015864521789384 1.22226744413572 0.636363636363636 17.2 17 2 abnormal T-helper 2 physiology 8.06778696022946e-06 0.00015864521789384 1.22226744413572 0.636363636363636 17.2 17 2 decreased sensitivity to xenobiotic induced morbidity/mortality 0.000531692203952147 0.00608084761991249 1.22226744413572 0.636363636363636 17.2 17 2 myeloid hyperplasia 0.000531692203952147 0.00608084761991249 1.22226744413572 0.636363636363636 17.2 17 2 intestinal inflammation 0.00459647165372055 0.0351266458944082 1.22226744413572 0.636363636363636 17.2 17 2 intracerebral hemorrhage 0.00459647165372055 0.0351266458944082 1.22226744413572 0.636363636363636 17.2 17 2 abnormal mesenteric lymph node morphology 0.00459647165372055 0.0351266458944082 1.22226744413572 0.636363636363636 17.2 17 2 increased mammary gland tumor incidence 0.00459647165372055 0.0351266458944082 1.22226744413572 0.636363636363636 17.2 17 2 impaired humoral immune response 0.00459647165372055 0.0351266458944082 1.22226744413572 0.636363636363636 17.2 17 2 absent semicircular canals 0.0445806469957271 0.19152739102223 1.22226744413572 0.636363636363636 17.2 17 2 decreased atrioventricular cushion size 0.0445806469957271 0.19152739102223 1.22226744413572 0.636363636363636 17.2 17 2 abnormal sebaceous gland morphology 0.0445806469957271 0.19152739102223 1.22226744413572 0.636363636363636 17.2 17 2 abnormal glossopharyngeal ganglion morphology 0.0445806469957271 0.19152739102223 1.22226744413572 0.636363636363636 17.2 17 2 vasculitis 0.0445806469957271 0.19152739102223 1.22226744413572 0.636363636363636 17.2 17 2 abnormal coronal suture morphology 0.0445806469957271 0.19152739102223 1.22226744413572 0.636363636363636 17.2 17 2 abnormal dorsal-ventral polarity of the somites 0.0445806469957271 0.19152739102223 1.22226744413572 0.636363636363636 17.2 17 2 aorta dilation 0.0445806469957271 0.19152739102223 1.22226744413572 0.636363636363636 17.2 17 2 abnormal extraembryonic ectoderm morphology 0.0445806469957271 0.19152739102223 1.22226744413572 0.636363636363636 17.2 17 2 abnormal dendritic cell chemotaxis 0.0445806469957271 0.19152739102223 1.22226744413572 0.636363636363636 17.2 17 2 reduced sympathetic cervical ganglion size 0.0445806469957271 0.19152739102223 1.22226744413572 0.636363636363636 17.2 17 2 decreased IgA level 1.58812727647838e-05 0.000297027563927817 1.21890956654194 0.634615384615385 17.2 17 2 hemopericardium 0.000127996674270783 0.00179882331778854 1.21800867255336 0.634146341463415 17.2 17 2 increased bone trabecula number 0.000127996674270783 0.00179882331778854 1.21800867255336 0.634146341463415 17.2 17 2 increased erythrocyte cell number 3.93995495577554e-06 8.48495753403822e-05 1.21644712297317 0.633333333333333 17.2 17 2 gastrointestinal hemorrhage 0.00106481871132963 0.0108332783003372 1.21644712297317 0.633333333333333 17.2 17 2 salivary gland inflammation 0.00106481871132963 0.0108332783003372 1.21644712297317 0.633333333333333 17.2 17 2 disorganized myocardium 0.00106481871132963 0.0108332783003372 1.21644712297317 0.633333333333333 17.2 17 2 abnormal craniofacial development 3.12882159255712e-05 0.000544261798006002 1.21514052026321 0.63265306122449 17.2 17 2 incomplete embryo turning 7.73077839303481e-06 0.000153842490021393 1.21307746335274 0.631578947368421 17.2 17 2 enlarged adrenal glands 0.00940850724233081 0.0604745782049041 1.21307746335274 0.631578947368421 17.2 17 2 decreased circulating magnesium level 0.00940850724233081 0.0604745782049041 1.21307746335274 0.631578947368421 17.2 17 2 increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 0.00940850724233081 0.0604745782049041 1.21307746335274 0.631578947368421 17.2 17 2 decreased IgG level 5.24331551665658e-10 2.66178517299658e-08 1.21125602572008 0.630630630630631 17.2 17 2 decreased heart weight 1.2141354188014e-07 3.68312421252253e-06 1.20933339710783 0.62962962962963 17.2 17 2 increased neuron apoptosis 1.2141354188014e-07 3.68312421252253e-06 1.20933339710783 0.62962962962963 17.2 17 2 diluted coat color 1.51768369249246e-05 0.000288186120998091 1.20933339710783 0.62962962962963 17.2 17 2 abnormal fetal cardiomyocyte proliferation 0.00213960403767813 0.0192835689990013 1.20933339710783 0.62962962962963 17.2 17 2 increased eosinophil cell number 3.76708285860897e-06 8.20156466612444e-05 1.20818602196826 0.629032258064516 17.2 17 2 pallor 9.6136895183418e-15 1.11228151985466e-12 1.20730090400344 0.628571428571429 17.2 17 2 decreased glycogen level 0.000504870998798037 0.00581419726625054 1.20730090400344 0.628571428571429 17.2 17 2 impaired adaptive thermogenesis 0.000504870998798037 0.00581419726625054 1.20730090400344 0.628571428571429 17.2 17 2 decreased T cell number 1.40192663002955e-13 1.29158981192537e-11 1.20491493383743 0.627329192546584 17.2 17 2 lethality throughout fetal growth and development, incomplete penetrance 8.81045886549314e-15 1.06907397209337e-12 1.20178251490439 0.625698324022346 17.2 17 2 failure of tooth eruption 0.0194274784995893 0.106444609620547 1.20044123977615 0.625 17.2 17 2 abnormal bone marrow cell number 0.0194274784995893 0.106444609620547 1.20044123977615 0.625 17.2 17 2 vasculature congestion 0.0194274784995893 0.106444609620547 1.20044123977615 0.625 17.2 17 2 delayed hair appearance 0.0194274784995893 0.106444609620547 1.20044123977615 0.625 17.2 17 2 intraventricular hemorrhage 0.0194274784995893 0.106444609620547 1.20044123977615 0.625 17.2 17 2 increased intestinal adenocarcinoma incidence 0.0194274784995893 0.106444609620547 1.20044123977615 0.625 17.2 17 2 abnormal epicardium morphology 0.0194274784995893 0.106444609620547 1.20044123977615 0.625 17.2 17 2 large intestinal inflammation 0.0194274784995893 0.106444609620547 1.20044123977615 0.625 17.2 17 2 increased pancreatic beta cell number 0.0194274784995893 0.106444609620547 1.20044123977615 0.625 17.2 17 2 small pancreas 0.0194274784995893 0.106444609620547 1.20044123977615 0.625 17.2 17 2 abnormal level of surface class II molecules 0.0194274784995893 0.106444609620547 1.20044123977615 0.625 17.2 17 2 dystonia 0.0194274784995893 0.106444609620547 1.20044123977615 0.625 17.2 17 2 abnormal exoccipital bone morphology 0.0975031608745705 0.332929461462586 1.20044123977615 0.625 17.2 17 2 abnormal bone marrow development 0.0975031608745705 0.332929461462586 1.20044123977615 0.625 17.2 17 2 absent mammary gland 0.0975031608745705 0.332929461462586 1.20044123977615 0.625 17.2 17 2 enlarged pituitary gland 0.0975031608745705 0.332929461462586 1.20044123977615 0.625 17.2 17 2 dermal cysts 0.0975031608745705 0.332929461462586 1.20044123977615 0.625 17.2 17 2 dry eyes 0.0975031608745705 0.332929461462586 1.20044123977615 0.625 17.2 17 2 absent eyelids 0.0975031608745705 0.332929461462586 1.20044123977615 0.625 17.2 17 2 poor grooming 0.0975031608745705 0.332929461462586 1.20044123977615 0.625 17.2 17 2 abnormal atrial thrombosis 0.0975031608745705 0.332929461462586 1.20044123977615 0.625 17.2 17 2 abnormal hepatobiliary system morphology 0.0975031608745705 0.332929461462586 1.20044123977615 0.625 17.2 17 2 abnormal secondary sex determination 0.0975031608745705 0.332929461462586 1.20044123977615 0.625 17.2 17 2 decreased aerobic running capacity 0.0975031608745705 0.332929461462586 1.20044123977615 0.625 17.2 17 2 abnormal muscle precursor cell migration 0.0975031608745705 0.332929461462586 1.20044123977615 0.625 17.2 17 2 hypospadia 0.0975031608745705 0.332929461462586 1.20044123977615 0.625 17.2 17 2 abnormal cellular cholesterol metabolism 0.0975031608745705 0.332929461462586 1.20044123977615 0.625 17.2 17 2 decreased susceptibility to age related obesity 0.0975031608745705 0.332929461462586 1.20044123977615 0.625 17.2 17 2 colon polyps 0.0975031608745705 0.332929461462586 1.20044123977615 0.625 17.2 17 2 abnormal platelet shape 0.0975031608745705 0.332929461462586 1.20044123977615 0.625 17.2 17 2 pulmonary interstitial fibrosis 0.0975031608745705 0.332929461462586 1.20044123977615 0.625 17.2 17 2 abnormal eyelid aperture 0.0975031608745705 0.332929461462586 1.20044123977615 0.625 17.2 17 2 abnormal miscarriage rate 0.0975031608745705 0.332929461462586 1.20044123977615 0.625 17.2 17 2 small frontal bone 0.0975031608745705 0.332929461462586 1.20044123977615 0.625 17.2 17 2 abnormal choroid pigmentation 0.0975031608745705 0.332929461462586 1.20044123977615 0.625 17.2 17 2 abnormal somite size 0.0975031608745705 0.332929461462586 1.20044123977615 0.625 17.2 17 2 abnormal vertebral body development 0.0975031608745705 0.332929461462586 1.20044123977615 0.625 17.2 17 2 choroidal neovascularization 0.0975031608745705 0.332929461462586 1.20044123977615 0.625 17.2 17 2 abnormal meiotic spindle morphology 0.0975031608745705 0.332929461462586 1.20044123977615 0.625 17.2 17 2 abnormal base-excision repair 0.0975031608745705 0.332929461462586 1.20044123977615 0.625 17.2 17 2 abnormal sphingomyelin level 0.0975031608745705 0.332929461462586 1.20044123977615 0.625 17.2 17 2 abnormal frontonasal prominence morphology 0.0975031608745705 0.332929461462586 1.20044123977615 0.625 17.2 17 2 increased caudal vertebrae number 0.0975031608745705 0.332929461462586 1.20044123977615 0.625 17.2 17 2 abnormal lateral plate mesoderm morphology 0.0975031608745705 0.332929461462586 1.20044123977615 0.625 17.2 17 2 abnormal brain ependyma morphology 0.0975031608745705 0.332929461462586 1.20044123977615 0.625 17.2 17 2 decreased quadriceps weight 0.0975031608745705 0.332929461462586 1.20044123977615 0.625 17.2 17 2 myocardial trabeculae hypoplasia 0.0975031608745705 0.332929461462586 1.20044123977615 0.625 17.2 17 2 delayed suture closure 0.0975031608745705 0.332929461462586 1.20044123977615 0.625 17.2 17 2 abnormal anterior commissure pars posterior morphology 0.0975031608745705 0.332929461462586 1.20044123977615 0.625 17.2 17 2 increased aorta wall thickness 0.0975031608745705 0.332929461462586 1.20044123977615 0.625 17.2 17 2 impaired neuron differentiation 0.0975031608745705 0.332929461462586 1.20044123977615 0.625 17.2 17 2 decreased cranium length 0.0975031608745705 0.332929461462586 1.20044123977615 0.625 17.2 17 2 abnormal heart echocardiography feature 0.0975031608745705 0.332929461462586 1.20044123977615 0.625 17.2 17 2 small thymus medulla 0.0975031608745705 0.332929461462586 1.20044123977615 0.625 17.2 17 2 absent hypoglossal canal 0.0975031608745705 0.332929461462586 1.20044123977615 0.625 17.2 17 2 increased mammary gland apoptosis 0.0975031608745705 0.332929461462586 1.20044123977615 0.625 17.2 17 2 hydrops fetalis 8.97054279815428e-07 2.24263569953857e-05 1.20044123977615 0.625 17.2 17 2 thymus atrophy 5.85914509524232e-05 0.000934270732334313 1.20044123977615 0.625 17.2 17 2 abnormal body weight 0.00431626064559876 0.0335521823622716 1.20044123977615 0.625 17.2 17 2 decreased fatty acid level 0.00431626064559876 0.0335521823622716 1.20044123977615 0.625 17.2 17 2 abnormal cellular extravasation 0.00431626064559876 0.0335521823622716 1.20044123977615 0.625 17.2 17 2 abnormal inner cell mass apoptosis 0.00431626064559876 0.0335521823622716 1.20044123977615 0.625 17.2 17 2 decreased hematocrit 3.7690415013513e-12 2.67871163846039e-10 1.19715235966718 0.623287671232877 17.2 17 2 decreased spleen weight 1.74701174827407e-06 4.06139413442218e-05 1.19696169995071 0.623188405797101 17.2 17 2 increased osteoclast cell number 7.00182217761823e-06 0.000139895844713457 1.19650536685885 0.622950819672131 17.2 17 2 increased double-negative T cell number 7.00182217761823e-06 0.000139895844713457 1.19650536685885 0.622950819672131 17.2 17 2 abnormal NK cell physiology 7.00182217761823e-06 0.000139895844713457 1.19650536685885 0.622950819672131 17.2 17 2 increased circulating bilirubin level 2.82664967392337e-05 0.000502235075991742 1.1959112728336 0.622641509433962 17.2 17 2 abnormal developmental patterning 2.14342547649582e-07 6.19973357300391e-06 1.19458542885041 0.621951219512195 17.2 17 2 abnormal angiogenesis 8.51893506819026e-07 2.14048999819427e-05 1.19395236820979 0.621621621621622 17.2 17 2 abnormal branching of the mammary ductal tree 0.000476158569933933 0.0055218855138026 1.19395236820979 0.621621621621622 17.2 17 2 decreased circulating chloride level 0.000476158569933933 0.0055218855138026 1.19395236820979 0.621621621621622 17.2 17 2 abnormal respiratory electron transport chain 0.000476158569933933 0.0055218855138026 1.19395236820979 0.621621621621622 17.2 17 2 preweaning lethality, incomplete penetrance 6.56316557718058e-31 3.26517487464734e-28 1.19281007297073 0.621026894865526 17.2 17 2 decreased trophoblast giant cell number 0.00200779177997328 0.0183280075327836 1.19216233467425 0.620689655172414 17.2 17 2 increased susceptibility to induced arthritis 0.00200779177997328 0.0183280075327836 1.19216233467425 0.620689655172414 17.2 17 2 abnormal locomotor behavior 5.13616937195387e-08 1.64854468551423e-06 1.19000262029984 0.619565217391304 17.2 17 2 abnormal embryo size 1.62639331459941e-09 7.16044844259475e-08 1.18981786597282 0.619469026548673 17.2 17 2 spleen hypoplasia 6.39100213065814e-09 2.48400278125189e-07 1.189008466064 0.619047619047619 17.2 17 2 abnormal humoral immune response 6.39100213065814e-09 2.48400278125189e-07 1.189008466064 0.619047619047619 17.2 17 2 skin edema 0.000226755986951661 0.00291501559453362 1.189008466064 0.619047619047619 17.2 17 2 abnormal spleen white pulp morphology 0.000226755986951661 0.00291501559453362 1.189008466064 0.619047619047619 17.2 17 2 abnormal scapula morphology 0.00874886062943935 0.0566002361917565 1.189008466064 0.619047619047619 17.2 17 2 trunk curl 0.00874886062943935 0.0566002361917565 1.189008466064 0.619047619047619 17.2 17 2 abnormal clavicle morphology 0.00874886062943935 0.0566002361917565 1.189008466064 0.619047619047619 17.2 17 2 absent segment of posterior cerebral artery 0.00874886062943935 0.0566002361917565 1.189008466064 0.619047619047619 17.2 17 2 enlarged liver sinusoidal spaces 0.000943310427442217 0.00979743084869526 1.18631840166114 0.617647058823529 17.2 17 2 decreased bone trabecula number 0.00010848595670126 0.00157812173856365 1.18511645799178 0.617021276595745 17.2 17 2 kinked neural tube 5.20992047739838e-05 0.000844278644138663 1.18197291301036 0.615384615384615 17.2 17 2 abnormal Schwann cell morphology 0.00401922117623505 0.0321473076395006 1.18197291301036 0.615384615384615 17.2 17 2 absent teeth 0.0405864249051611 0.177276087711305 1.18197291301036 0.615384615384615 17.2 17 2 lymphoid hypoplasia 0.0405864249051611 0.177276087711305 1.18197291301036 0.615384615384615 17.2 17 2 abnormal pulmonary alveolus epithelial cell morphology 0.0405864249051611 0.177276087711305 1.18197291301036 0.615384615384615 17.2 17 2 dystrophic cardiac calcinosis 0.0405864249051611 0.177276087711305 1.18197291301036 0.615384615384615 17.2 17 2 abnormal insulin secretion 0.0405864249051611 0.177276087711305 1.18197291301036 0.615384615384615 17.2 17 2 abnormal vestibulocochlear ganglion morphology 0.0405864249051611 0.177276087711305 1.18197291301036 0.615384615384615 17.2 17 2 increased circulating thyroxine level 0.0405864249051611 0.177276087711305 1.18197291301036 0.615384615384615 17.2 17 2 abnormal aorta tunica media morphology 0.0405864249051611 0.177276087711305 1.18197291301036 0.615384615384615 17.2 17 2 absent hypoglossal nerve 0.0405864249051611 0.177276087711305 1.18197291301036 0.615384615384615 17.2 17 2 impaired natural killer cell mediated cytotoxicity 2.50988801293178e-05 0.000450783135896592 1.1793808671485 0.614035087719298 17.2 17 2 abnormal neurocranium morphology 1.47257939826917e-06 3.50990090739003e-05 1.17803300330033 0.613333333333333 17.2 17 2 hypoglycemia 8.84602563305276e-08 2.76786022166273e-06 1.17720689319984 0.612903225806452 17.2 17 2 abnormal object recognition memory 0.00187142597788568 0.0171777569003344 1.17720689319984 0.612903225806452 17.2 17 2 decreased thymus weight 0.00187142597788568 0.0171777569003344 1.17720689319984 0.612903225806452 17.2 17 2 abnormal respiratory system physiology 0.000101701822047453 0.00148813695495906 1.17594243896439 0.612244897959184 17.2 17 2 abnormal craniofacial morphology 2.11581429669306e-08 7.30984453197777e-07 1.17480074727608 0.611650485436893 17.2 17 2 prenatal lethality, complete penetrance 3.70281113516129e-20 8.00934147714235e-18 1.17453243603998 0.611510791366906 17.2 17 2 abnormal neuronal precursor proliferation 4.8835962161719e-05 0.00079503671744359 1.17376476778113 0.611111111111111 17.2 17 2 axon degeneration 4.8835962161719e-05 0.00079503671744359 1.17376476778113 0.611111111111111 17.2 17 2 abnormal mitral valve morphology 0.0178371993741683 0.100498376994889 1.17376476778113 0.611111111111111 17.2 17 2 abnormal radius morphology 0.0178371993741683 0.100498376994889 1.17376476778113 0.611111111111111 17.2 17 2 absent allantois 0.0178371993741683 0.100498376994889 1.17376476778113 0.611111111111111 17.2 17 2 increased circulating glycerol level 0.0178371993741683 0.100498376994889 1.17376476778113 0.611111111111111 17.2 17 2 decreased pulmonary respiratory rate 0.0178371993741683 0.100498376994889 1.17376476778113 0.611111111111111 17.2 17 2 impaired leukocyte tethering or rolling 0.0178371993741683 0.100498376994889 1.17376476778113 0.611111111111111 17.2 17 2 thick ventricular wall 0.00041671641469927 0.00495972287829873 1.17116218514746 0.609756097560976 17.2 17 2 lethality at weaning, incomplete penetrance 0.00041671641469927 0.00495972287829873 1.17116218514746 0.609756097560976 17.2 17 2 increased sacral vertebrae number 1.13622709335882e-05 0.000219098053855044 1.17043020878175 0.609375 17.2 17 2 microcephaly 5.50032733100763e-06 0.000112609582188325 1.16912538134721 0.608695652173913 17.2 17 2 delayed wound healing 0.000198495136038976 0.00259818149570633 1.16912538134721 0.608695652173913 17.2 17 2 abnormal circulating insulin level 0.00807011913344434 0.0529668109352053 1.16912538134721 0.608695652173913 17.2 17 2 conjunctivitis 0.00807011913344434 0.0529668109352053 1.16912538134721 0.608695652173913 17.2 17 2 abnormal vertebral artery topology 0.00807011913344434 0.0529668109352053 1.16912538134721 0.608695652173913 17.2 17 2 abnormal trophoblast layer morphology 9.49838991297563e-05 0.00140638362550755 1.16748795084112 0.607843137254902 17.2 17 2 abnormal heart development 8.39945385371388e-12 5.57163772296354e-10 1.1670112305672 0.607594936708861 17.2 17 2 abnormal placenta labyrinth morphology 1.29614404687197e-06 3.13025079280974e-05 1.1670112305672 0.607594936708861 17.2 17 2 abnormal nervous system morphology 1.29614404687197e-06 3.13025079280974e-05 1.1670112305672 0.607594936708861 17.2 17 2 double outlet right ventricle 1.86635263806369e-08 6.53880589744144e-07 1.16678400875439 0.607476635514019 17.2 17 2 shortened head 0.00371830458809769 0.0298363956867516 1.16614291863969 0.607142857142857 17.2 17 2 abnormal spleen germinal center morphology 0.00371830458809769 0.0298363956867516 1.16614291863969 0.607142857142857 17.2 17 2 failure of blastocyst to hatch from the zona pellucida 0.00371830458809769 0.0298363956867516 1.16614291863969 0.607142857142857 17.2 17 2 subcutaneous edema 0.00371830458809769 0.0298363956867516 1.16614291863969 0.607142857142857 17.2 17 2 anophthalmia 3.07240029532964e-07 8.44485716533975e-06 1.16537216985011 0.606741573033708 17.2 17 2 enlarged pericardium 0.00173481020415068 0.0161020163538239 1.16406423251021 0.606060606060606 17.2 17 2 decreased brown adipose tissue amount 0.00173481020415068 0.0161020163538239 1.16406423251021 0.606060606060606 17.2 17 2 abnormal locomotor coordination 0.00173481020415068 0.0161020163538239 1.16406423251021 0.606060606060606 17.2 17 2 increased bone mineral content 1.74830344223419e-08 6.16865930859226e-07 1.16299628367304 0.605504587155963 17.2 17 2 prenatal lethality, incomplete penetrance 5.45431294525442e-21 1.50751149459115e-18 1.16253256904638 0.605263157894737 17.2 17 2 decreased hair follicle number 0.000816832335114511 0.00859141832387885 1.16253256904638 0.605263157894737 17.2 17 2 small spleen 2.87291435573448e-07 8.03339981073804e-06 1.16086625384947 0.604395604395604 17.2 17 2 ataxia 2.52444232405148e-14 2.6721490557779e-12 1.16003034655596 0.603960396039604 17.2 17 2 atrioventricular septal defect 8.84157122555079e-05 0.00131303930886911 1.15967153729319 0.60377358490566 17.2 17 2 decreased susceptibility to hepatic steatosis 2.04826665914796e-05 0.000374637008428717 1.15852106949825 0.603174603174603 17.2 17 2 abnormal embryo development 4.61593182288782e-10 2.3921105019653e-08 1.15807272543111 0.602941176470588 17.2 17 2 ventricular septal defect 4.61593182288782e-10 2.3921105019653e-08 1.15807272543111 0.602941176470588 17.2 17 2 increased bone mineral density 1.52686133132312e-08 5.5044457415453e-07 1.15582306980217 0.601769911504425 17.2 17 2 thick pulmonary interalveolar septum 0.00160096957040849 0.0150800440705482 1.15242359018511 0.6 17.2 17 2 short stride length 0.000171200830776166 0.00228344271611642 1.15242359018511 0.6 17.2 17 2 liver hemorrhage 0.00342225138293875 0.0278653038136175 1.15242359018511 0.6 17.2 17 2 abnormal cellular respiration 0.00342225138293875 0.0278653038136175 1.15242359018511 0.6 17.2 17 2 ruffled hair 0.00739934116365164 0.049544713713549 1.15242359018511 0.6 17.2 17 2 spontaneous skin ulceration 0.00739934116365164 0.049544713713549 1.15242359018511 0.6 17.2 17 2 abnormal egg cylinder morphology 0.00739934116365164 0.049544713713549 1.15242359018511 0.6 17.2 17 2 abnormal keratinocyte physiology 0.00739934116365164 0.049544713713549 1.15242359018511 0.6 17.2 17 2 increased cellular sensitivity to ionizing radiation 0.00739934116365164 0.049544713713549 1.15242359018511 0.6 17.2 17 2 abnormal preimplantation embryo development 0.00739934116365164 0.049544713713549 1.15242359018511 0.6 17.2 17 2 decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 0.00739934116365164 0.049544713713549 1.15242359018511 0.6 17.2 17 2 brain inflammation 0.0162597250806253 0.0927662067386592 1.15242359018511 0.6 17.2 17 2 spleen atrophy 0.0162597250806253 0.0927662067386592 1.15242359018511 0.6 17.2 17 2 decreased circulating VLDL cholesterol level 0.0162597250806253 0.0927662067386592 1.15242359018511 0.6 17.2 17 2 abnormal induced retinal neovascularization 0.0162597250806253 0.0927662067386592 1.15242359018511 0.6 17.2 17 2 abnormal sperm mitochondrial sheath morphology 0.0162597250806253 0.0927662067386592 1.15242359018511 0.6 17.2 17 2 decreased muscle cell glucose uptake 0.0162597250806253 0.0927662067386592 1.15242359018511 0.6 17.2 17 2 absent incisors 0.0366305535090442 0.171275379424337 1.15242359018511 0.6 17.2 17 2 arthritis 0.0366305535090442 0.171275379424337 1.15242359018511 0.6 17.2 17 2 abnormal glial cell morphology 0.0366305535090442 0.171275379424337 1.15242359018511 0.6 17.2 17 2 abnormal olfactory nerve morphology 0.0366305535090442 0.171275379424337 1.15242359018511 0.6 17.2 17 2 lactation failure 0.0366305535090442 0.171275379424337 1.15242359018511 0.6 17.2 17 2 kidney hemorrhage 0.086181864645054 0.310691867108075 1.15242359018511 0.6 17.2 17 2 enlarged testis 0.086181864645054 0.310691867108075 1.15242359018511 0.6 17.2 17 2 fused cornea and lens 0.086181864645054 0.310691867108075 1.15242359018511 0.6 17.2 17 2 absent trophoblast giant cells 0.086181864645054 0.310691867108075 1.15242359018511 0.6 17.2 17 2 decreased incidence of induced tumors 0.086181864645054 0.310691867108075 1.15242359018511 0.6 17.2 17 2 abnormal PNS synaptic transmission 0.086181864645054 0.310691867108075 1.15242359018511 0.6 17.2 17 2 intestinal edema 0.086181864645054 0.310691867108075 1.15242359018511 0.6 17.2 17 2 bifid ureter 0.086181864645054 0.310691867108075 1.15242359018511 0.6 17.2 17 2 abnormal glial cell physiology 0.086181864645054 0.310691867108075 1.15242359018511 0.6 17.2 17 2 abnormal submandibular gland morphology 0.086181864645054 0.310691867108075 1.15242359018511 0.6 17.2 17 2 abnormal ear physiology 0.086181864645054 0.310691867108075 1.15242359018511 0.6 17.2 17 2 abnormal deltoid tuberosity morphology 0.086181864645054 0.310691867108075 1.15242359018511 0.6 17.2 17 2 increased susceptibility to atherosclerosis 0.086181864645054 0.310691867108075 1.15242359018511 0.6 17.2 17 2 aorta stenosis 0.086181864645054 0.310691867108075 1.15242359018511 0.6 17.2 17 2 abnormal inferior vena cava valve morphology 0.086181864645054 0.310691867108075 1.15242359018511 0.6 17.2 17 2 thin ventricle myocardium compact layer 0.086181864645054 0.310691867108075 1.15242359018511 0.6 17.2 17 2 decreased trabecular bone connectivity density 0.086181864645054 0.310691867108075 1.15242359018511 0.6 17.2 17 2 increased circulating alkaline phosphatase level 2.17872515819379e-11 1.37204527367267e-09 1.15005234822999 0.598765432098765 17.2 17 2 abnormal coat/hair pigmentation 2.70958078382142e-08 9.23298931473394e-07 1.14899375807146 0.598214285714286 17.2 17 2 abnormal eye morphology 7.11395468612518e-10 3.43610918091969e-08 1.14689637872139 0.597122302158273 17.2 17 2 prenatal lethality 3.65714409502533e-05 0.000610546707139296 1.14622776443142 0.596774193548387 17.2 17 2 disheveled coat 0.000696069984916347 0.0074312192595683 1.14327737121538 0.595238095238095 17.2 17 2 abnormal heart atrium morphology 0.00313679411356701 0.0257517338531285 1.14041917778734 0.59375 17.2 17 2 abnormal spongiotrophoblast layer morphology 0.00313679411356701 0.0257517338531285 1.14041917778734 0.59375 17.2 17 2 increased hemoglobin content 7.01516135147921e-05 0.00107056526759537 1.13940185470279 0.593220338983051 17.2 17 2 increased oxygen consumption 1.72754668560717e-06 4.0349975403266e-05 1.13902331588063 0.593023255813954 17.2 17 2 abnormal axon morphology 9.06162787354517e-08 2.81662568281825e-06 1.13819613845443 0.592592592592593 17.2 17 2 abnormal cell adhesion 0.000145986257846475 0.00197896902666543 1.13819613845443 0.592592592592593 17.2 17 2 abnormal atrioventricular cushion morphology 0.00675320974140876 0.0460235869363131 1.13819613845443 0.592592592592593 17.2 17 2 abnormal trigeminal nerve morphology 0.00675320974140876 0.0460235869363131 1.13819613845443 0.592592592592593 17.2 17 2 abnormal trigeminal ganglion morphology 0.00675320974140876 0.0460235869363131 1.13819613845443 0.592592592592593 17.2 17 2 abnormal brain commissure morphology 0.00675320974140876 0.0460235869363131 1.13819613845443 0.592592592592593 17.2 17 2 abnormal eye muscle morphology 0.00675320974140876 0.0460235869363131 1.13819613845443 0.592592592592593 17.2 17 2 abnormal skin appearance 0.00675320974140876 0.0460235869363131 1.13819613845443 0.592592592592593 17.2 17 2 thick interventricular septum 0.00675320974140876 0.0460235869363131 1.13819613845443 0.592592592592593 17.2 17 2 increased circulating LDL cholesterol level 0.000304902143183749 0.00369972722521744 1.13674435766558 0.591836734693878 17.2 17 2 abnormal CD4-positive, alpha-beta T cell physiology 1.50923209778696e-05 0.000287679298332955 1.13619227201348 0.591549295774648 17.2 17 2 embryonic lethality during organogenesis, incomplete penetrance 9.31368817391312e-15 1.10322853964804e-12 1.135721799023 0.591304347826087 17.2 17 2 decreased macrophage cell number 0.000639622719994691 0.00690265299777351 1.13496262669745 0.590909090909091 17.2 17 2 decreased blood urea nitrogen level 0.000639622719994691 0.00690265299777351 1.13496262669745 0.590909090909091 17.2 17 2 abnormal long bone epiphysis morphology 0.0147467558165887 0.0849133219763066 1.13496262669745 0.590909090909091 17.2 17 2 abnormal facial nerve morphology 0.0147467558165887 0.0849133219763066 1.13496262669745 0.590909090909091 17.2 17 2 increased activated T cell number 0.0147467558165887 0.0849133219763066 1.13496262669745 0.590909090909091 17.2 17 2 increased skin papilloma incidence 0.0147467558165887 0.0849133219763066 1.13496262669745 0.590909090909091 17.2 17 2 abnormal vascular branching morphogenesis 0.0147467558165887 0.0849133219763066 1.13496262669745 0.590909090909091 17.2 17 2 prolonged PR interval 0.0147467558165887 0.0849133219763066 1.13496262669745 0.590909090909091 17.2 17 2 abnormal limb posture 0.0147467558165887 0.0849133219763066 1.13496262669745 0.590909090909091 17.2 17 2 decreased circulating estradiol level 0.0147467558165887 0.0849133219763066 1.13496262669745 0.590909090909091 17.2 17 2 enlarged liver 3.51012597994204e-07 9.54255560120856e-06 1.13321653034869 0.59 17.2 17 2 thin ventricular wall 1.47451113496385e-06 3.50990090739003e-05 1.13108241258908 0.588888888888889 17.2 17 2 abnormal immune system physiology 1.71902066960035e-08 6.10866273661554e-07 1.13073820004721 0.588709677419355 17.2 17 2 pericardial edema 2.87362766479229e-05 0.000508765040296856 1.12982704920108 0.588235294117647 17.2 17 2 abnormal interatrial septum morphology 0.032886342892972 0.155967164816526 1.12982704920108 0.588235294117647 17.2 17 2 abnormal vagus nerve morphology 0.032886342892972 0.155967164816526 1.12982704920108 0.588235294117647 17.2 17 2 abnormal embryonic-extraembryonic boundary morphology 0.032886342892972 0.155967164816526 1.12982704920108 0.588235294117647 17.2 17 2 abnormal melanosome morphology 0.032886342892972 0.155967164816526 1.12982704920108 0.588235294117647 17.2 17 2 abnormal glucose homeostasis 1.0307982642643e-11 6.74765969041433e-10 1.12920626510812 0.587912087912088 17.2 17 2 premature death 3.82748757502895e-50 4.76043767144226e-47 1.1287772679707 0.587688734030197 17.2 17 2 increased circulating aspartate transaminase level 5.94670044608166e-05 0.000944151514995468 1.12803367293251 0.587301587301587 17.2 17 2 hemorrhage 1.28389204726309e-14 1.41941398558531e-12 1.1279039393301 0.587234042553191 17.2 17 2 abnormal microglial cell morphology 0.00614153106627392 0.0429130857510011 1.12593109385901 0.586206896551724 17.2 17 2 decreased bone strength 0.00614153106627392 0.0429130857510011 1.12593109385901 0.586206896551724 17.2 17 2 polychromatophilia 0.00614153106627392 0.0429130857510011 1.12593109385901 0.586206896551724 17.2 17 2 palatal shelves fail to meet at midline 0.00123332732140837 0.0118223572716891 1.12431569774157 0.585365853658537 17.2 17 2 abnormal lipid homeostasis 1.35008862529319e-08 4.90269409549899e-07 1.12287426735985 0.584615384615385 17.2 17 2 decreased monocyte cell number 5.46059395964336e-05 0.000879173299327693 1.12287426735985 0.584615384615385 17.2 17 2 absent mesoderm 0.000113107826149594 0.00161235368221842 1.12041182379107 0.583333333333333 17.2 17 2 intracranial hemorrhage 0.000113107826149594 0.00161235368221842 1.12041182379107 0.583333333333333 17.2 17 2 impaired wound healing 0.00261051617006256 0.022162658611026 1.12041182379107 0.583333333333333 17.2 17 2 small heart 0.000536239561748185 0.00610478677276252 1.12041182379107 0.583333333333333 17.2 17 2 vertebral transformation 0.000536239561748185 0.00610478677276252 1.12041182379107 0.583333333333333 17.2 17 2 ocular hypertelorism 0.0133255210164282 0.0802596453471309 1.12041182379107 0.583333333333333 17.2 17 2 abnormal vasodilation 0.0133255210164282 0.0802596453471309 1.12041182379107 0.583333333333333 17.2 17 2 increased hemangiosarcoma incidence 0.0133255210164282 0.0802596453471309 1.12041182379107 0.583333333333333 17.2 17 2 abnormal truncus arteriosus septation 0.0133255210164282 0.0802596453471309 1.12041182379107 0.583333333333333 17.2 17 2 abnormal pilomotor reflex 0.0759104255030925 0.281083685295511 1.12041182379107 0.583333333333333 17.2 17 2 abnormal thymus involution 0.0759104255030925 0.281083685295511 1.12041182379107 0.583333333333333 17.2 17 2 abnormal tracheal ciliated epithelium morphology 0.0759104255030925 0.281083685295511 1.12041182379107 0.583333333333333 17.2 17 2 increased circulating parathyroid hormone level 0.0759104255030925 0.281083685295511 1.12041182379107 0.583333333333333 17.2 17 2 abnormal gastrocnemius morphology 0.0759104255030925 0.281083685295511 1.12041182379107 0.583333333333333 17.2 17 2 loss of dopaminergic neurons 0.0759104255030925 0.281083685295511 1.12041182379107 0.583333333333333 17.2 17 2 decreased circulating ketone body level 0.0759104255030925 0.281083685295511 1.12041182379107 0.583333333333333 17.2 17 2 increased fear-related response 0.0759104255030925 0.281083685295511 1.12041182379107 0.583333333333333 17.2 17 2 abnormal nucleotide metabolism 0.0759104255030925 0.281083685295511 1.12041182379107 0.583333333333333 17.2 17 2 abnormal fatty acid level 0.0759104255030925 0.281083685295511 1.12041182379107 0.583333333333333 17.2 17 2 abnormal thymus corticomedullary boundary morphology 0.0759104255030925 0.281083685295511 1.12041182379107 0.583333333333333 17.2 17 2 decreased keratinocyte proliferation 0.0759104255030925 0.281083685295511 1.12041182379107 0.583333333333333 17.2 17 2 increased skeletal muscle glycogen level 0.0759104255030925 0.281083685295511 1.12041182379107 0.583333333333333 17.2 17 2 persistent right dorsal aorta 0.0759104255030925 0.281083685295511 1.12041182379107 0.583333333333333 17.2 17 2 reduced fertility 5.62597821037775e-09 2.22136838068486e-07 1.1192603214028 0.58273381294964 17.2 17 2 increased sensitivity to xenobiotic induced morbidity/mortality 2.33015635874766e-07 6.65881432286182e-06 1.1175016632098 0.581818181818182 17.2 17 2 decreased circulating calcium level 0.0002349273965708 0.00299683025112751 1.1175016632098 0.581818181818182 17.2 17 2 neonatal lethality, incomplete penetrance 2.81117695735596e-15 3.49640134071147e-13 1.11548693665353 0.580769230769231 17.2 17 2 autoimmune response 0.00556954809762762 0.0393028394123368 1.11524863566301 0.580645161290323 17.2 17 2 abnormal retinal photoreceptor layer morphology 0.00556954809762762 0.0393028394123368 1.11524863566301 0.580645161290323 17.2 17 2 decreased neuronal precursor cell number 0.00556954809762762 0.0393028394123368 1.11524863566301 0.580645161290323 17.2 17 2 decreased double-negative T cell number 0.00556954809762762 0.0393028394123368 1.11524863566301 0.580645161290323 17.2 17 2 preaxial polydactyly 0.00556954809762762 0.0393028394123368 1.11524863566301 0.580645161290323 17.2 17 2 decreased susceptibility to bacterial infection induced morbidity/mortality 0.00556954809762762 0.0393028394123368 1.11524863566301 0.580645161290323 17.2 17 2 increased insulin sensitivity 4.75896841920739e-09 1.95668329632701e-07 1.11481536113478 0.58041958041958 17.2 17 2 abnormal neural tube morphology 4.8066594194763e-10 2.46527119710254e-08 1.11448371890329 0.580246913580247 17.2 17 2 decreased brain weight 0.000214609666413713 0.00277320283222915 1.11198767474001 0.578947368421053 17.2 17 2 increased hepatocellular carcinoma incidence 0.000214609666413713 0.00277320283222915 1.11198767474001 0.578947368421053 17.2 17 2 increased bone marrow cell number 0.00237277813751447 0.0207097740949728 1.11198767474001 0.578947368421053 17.2 17 2 abnormal compact bone morphology 0.00237277813751447 0.0207097740949728 1.11198767474001 0.578947368421053 17.2 17 2 kyphoscoliosis 0.0294266510554449 0.140902395573473 1.11198767474001 0.578947368421053 17.2 17 2 increased liver adenoma incidence 0.0294266510554449 0.140902395573473 1.11198767474001 0.578947368421053 17.2 17 2 increased circulating VLDL cholesterol level 0.0294266510554449 0.140902395573473 1.11198767474001 0.578947368421053 17.2 17 2 increased liver cholesterol level 0.0294266510554449 0.140902395573473 1.11198767474001 0.578947368421053 17.2 17 2 decreased susceptibility to weight gain 0.0294266510554449 0.140902395573473 1.11198767474001 0.578947368421053 17.2 17 2 weight loss 1.68719336437353e-10 9.64803102041187e-09 1.10852173913043 0.577142857142857 17.2 17 2 decreased circulating glucose level 7.68603694090128e-16 1.12464805238188e-13 1.10836438482558 0.577060931899642 17.2 17 2 increased urine protein level 1.8631861092128e-05 0.000342042468388697 1.10809960594722 0.576923076923077 17.2 17 2 abnormal nasal bone morphology 0.012008595691947 0.0729459872618269 1.10809960594722 0.576923076923077 17.2 17 2 decreased circulating glycerol level 0.012008595691947 0.0729459872618269 1.10809960594722 0.576923076923077 17.2 17 2 abnormal erythrocyte osmotic lysis 0.012008595691947 0.0729459872618269 1.10809960594722 0.576923076923077 17.2 17 2 impaired glucose tolerance 3.35837650161237e-14 3.34158461910431e-12 1.1075038534709 0.576612903225806 17.2 17 2 small testis 1.42569475008333e-15 1.91698145450393e-13 1.10649366448932 0.576086956521739 17.2 17 2 abnormal skeleton physiology 0.0050394865620606 0.0363354284728282 1.1058610208847 0.575757575757576 17.2 17 2 cardiovascular system phenotype 0.0050394865620606 0.0363354284728282 1.1058610208847 0.575757575757576 17.2 17 2 abnormal behavior 1.30756630975837e-15 1.8069839975133e-13 1.10544229274351 0.575539568345324 17.2 17 2 abnormal pancreatic beta cell morphology 0.00215257644186281 0.0193654028901762 1.10440594059406 0.575 17.2 17 2 increased respiratory quotient 0.00093073893422418 0.0096870840957433 1.1033842884751 0.574468085106383 17.2 17 2 sparse hair 1.55388040187712e-05 0.000291719056578817 1.10089245403862 0.573170731707317 17.2 17 2 abnormal heart morphology 7.93797278613222e-13 6.47400239524718e-11 1.09754627636677 0.571428571428571 17.2 17 2 abnormal embryonic tissue morphology 1.06200106794125e-08 3.94287709925948e-07 1.09754627636677 0.571428571428571 17.2 17 2 holoprosencephaly 0.00455159697150181 0.0351072789662349 1.09754627636677 0.571428571428571 17.2 17 2 myoclonus 0.0107997499458235 0.0664959851243467 1.09754627636677 0.571428571428571 17.2 17 2 increased incidence of induced tumors 0.02627421101554 0.127401754193286 1.09754627636677 0.571428571428571 17.2 17 2 vascular ring 0.02627421101554 0.127401754193286 1.09754627636677 0.571428571428571 17.2 17 2 increased muscle cell glucose uptake 0.02627421101554 0.127401754193286 1.09754627636677 0.571428571428571 17.2 17 2 abnormal interparietal bone morphology 0.0667850673625262 0.251899704418929 1.09754627636677 0.571428571428571 17.2 17 2 decreased coping response 0.0667850673625262 0.251899704418929 1.09754627636677 0.571428571428571 17.2 17 2 abnormal sagittal suture morphology 0.0667850673625262 0.251899704418929 1.09754627636677 0.571428571428571 17.2 17 2 split sternum 0.0667850673625262 0.251899704418929 1.09754627636677 0.571428571428571 17.2 17 2 decreased CNS synapse formation 0.0667850673625262 0.251899704418929 1.09754627636677 0.571428571428571 17.2 17 2 abnormal iris pigmentation 0.0667850673625262 0.251899704418929 1.09754627636677 0.571428571428571 17.2 17 2 spina bifida occulta 0.0667850673625262 0.251899704418929 1.09754627636677 0.571428571428571 17.2 17 2 decreased cornea thickness 0.0667850673625262 0.251899704418929 1.09754627636677 0.571428571428571 17.2 17 2 increased pulmonary respiratory rate 0.0667850673625262 0.251899704418929 1.09754627636677 0.571428571428571 17.2 17 2 abnormal vitelline vein topology 0.0667850673625262 0.251899704418929 1.09754627636677 0.571428571428571 17.2 17 2 perinatal lethality, incomplete penetrance 1.60024275166847e-12 1.21070866378973e-10 1.09633217650353 0.570796460176991 17.2 17 2 abnormal bone mineralization 2.34229649547903e-07 6.65881432286182e-06 1.09527861877097 0.570247933884298 17.2 17 2 abnormal liver morphology 3.71593835467844e-10 1.98782723812099e-08 1.09448050464507 0.569832402234637 17.2 17 2 edema 8.20584223951814e-10 3.8513269001512e-08 1.0943557348657 0.569767441860465 17.2 17 2 hunched posture 2.89799472330469e-05 0.000511259707391519 1.09407302865675 0.569620253164557 17.2 17 2 abnormal forebrain development 6.5253364585139e-05 0.00101062663928431 1.09373535179605 0.569444444444444 17.2 17 2 reduced female fertility 1.22150487058371e-12 9.64601068437137e-11 1.09281547345139 0.568965517241379 17.2 17 2 abnormal gastrulation 0.000765637229276085 0.00812163158986892 1.09216614756105 0.568627450980392 17.2 17 2 abnormal thrombosis 0.000765637229276085 0.00812163158986892 1.09216614756105 0.568627450980392 17.2 17 2 increased heart weight 3.96410596665176e-08 1.30605478040348e-06 1.09162426408421 0.568345323741007 17.2 17 2 abnormal astrocyte morphology 0.00176348180827109 0.0162770352433185 1.09131021797832 0.568181818181818 17.2 17 2 decreased width of hypertrophic chondrocyte zone 0.00410486141789508 0.0322580277198366 1.09013042314807 0.567567567567568 17.2 17 2 abnormal calcium ion homeostasis 0.00410486141789508 0.0322580277198366 1.09013042314807 0.567567567567568 17.2 17 2 abnormal enzyme/coenzyme activity 6.7322219645225e-09 2.59634141655034e-07 1.08880785059952 0.56687898089172 17.2 17 2 decreased insulin secretion 1.06949685396815e-05 0.000207032951303173 1.08840005739704 0.566666666666667 17.2 17 2 abnormal lipid level 2.39698046615833e-05 0.000432064413736873 1.08762868953213 0.566265060240964 17.2 17 2 abnormal neuron morphology 4.3519336652074e-06 9.22070046483387e-05 1.08645995034286 0.565656565656566 17.2 17 2 increased mean corpuscular hemoglobin 4.3519336652074e-06 9.22070046483387e-05 1.08645995034286 0.565656565656566 17.2 17 2 hydroencephaly 7.97968507068034e-07 2.01517427546369e-05 1.08561642553669 0.565217391304348 17.2 17 2 abnormal cranial nerve morphology 0.0234263835046764 0.115050600134023 1.08561642553669 0.565217391304348 17.2 17 2 failure of embryo implantation 0.0234263835046764 0.115050600134023 1.08561642553669 0.565217391304348 17.2 17 2 pancreas inflammation 0.0234263835046764 0.115050600134023 1.08561642553669 0.565217391304348 17.2 17 2 abnormal nasal cavity morphology 0.0234263835046764 0.115050600134023 1.08561642553669 0.565217391304348 17.2 17 2 increased susceptibility to age related obesity 0.0234263835046764 0.115050600134023 1.08561642553669 0.565217391304348 17.2 17 2 abnormal Wolffian duct morphology 0.0234263835046764 0.115050600134023 1.08561642553669 0.565217391304348 17.2 17 2 abnormal ulna morphology 0.0234263835046764 0.115050600134023 1.08561642553669 0.565217391304348 17.2 17 2 abnormal palatal shelf fusion at midline 0.0234263835046764 0.115050600134023 1.08561642553669 0.565217391304348 17.2 17 2 abnormal hepatocyte physiology 0.0234263835046764 0.115050600134023 1.08561642553669 0.565217391304348 17.2 17 2 abnormal hematopoietic stem cell physiology 0.0234263835046764 0.115050600134023 1.08561642553669 0.565217391304348 17.2 17 2 pericardial effusion 0.000275317506842418 0.00345013752277337 1.08426950689459 0.564516129032258 17.2 17 2 abnormal pulmonary alveolus morphology 3.95680431738064e-06 8.48495753403822e-05 1.08396278284738 0.564356435643564 17.2 17 2 abnormal heart ventricle morphology 4.8900750861857e-05 0.00079503671744359 1.0834751702595 0.564102564102564 17.2 17 2 decreased trabecular bone volume 0.00369747477607741 0.0298363956867516 1.0834751702595 0.564102564102564 17.2 17 2 abnormal cardiovascular system physiology 1.34093329774431e-07 4.04311706441086e-06 1.08310487799352 0.56390977443609 17.2 17 2 increased circulating free fatty acid level 0.000110180333714101 0.00158088163448495 1.08208787810808 0.563380281690141 17.2 17 2 decreased total body fat amount 1.03507573762889e-16 1.71650059823458e-14 1.08111594288822 0.562874251497006 17.2 17 2 decreased circulating cholesterol level 7.88823292149931e-10 3.7375198842342e-08 1.08105309461809 0.562841530054645 17.2 17 2 failure of primitive streak formation 0.0086973746485627 0.0565613580086267 1.08039711579854 0.5625 17.2 17 2 abnormal extraembryonic endoderm formation 0.0587487928069149 0.22569516927753 1.08039711579854 0.5625 17.2 17 2 abnormal olfaction 0.0587487928069149 0.22569516927753 1.08039711579854 0.5625 17.2 17 2 abnormal wound healing 0.0587487928069149 0.22569516927753 1.08039711579854 0.5625 17.2 17 2 abnormal thoracic cage shape 0.0587487928069149 0.22569516927753 1.08039711579854 0.5625 17.2 17 2 abnormal pulmonary alveolus wall morphology 0.0587487928069149 0.22569516927753 1.08039711579854 0.5625 17.2 17 2 decreased adipocyte glucose uptake 0.0587487928069149 0.22569516927753 1.08039711579854 0.5625 17.2 17 2 abnormal fertility/fecundity 9.98175484517467e-05 0.00146487405176236 1.07875267574405 0.561643835616438 17.2 17 2 abnormal circulating amino acid level 0.000566720889926304 0.00629338488255215 1.07829107853577 0.56140350877193 17.2 17 2 Leydig cell hyperplasia 0.00332717254022125 0.0271801040847302 1.07746921033567 0.560975609756098 17.2 17 2 limb grasping 1.3092828438761e-09 5.97166408484131e-08 1.07643961720587 0.56043956043956 17.2 17 2 postnatal lethality 7.00896003103559e-09 2.68227508880016e-07 1.07605817155838 0.560240963855422 17.2 17 2 testicular atrophy 0.00129670129861213 0.0123347781273334 1.07559535083943 0.56 17.2 17 2 decreased oocyte number 0.00129670129861213 0.0123347781273334 1.07559535083943 0.56 17.2 17 2 increased liver glycogen level 0.0208679317381438 0.110017294359064 1.07559535083943 0.56 17.2 17 2 abnormal left-right axis patterning 0.00299145350445782 0.0250969328578038 1.07202194435824 0.558139534883721 17.2 17 2 decreased oxygen consumption 0.00299145350445782 0.0250969328578038 1.07202194435824 0.558139534883721 17.2 17 2 abnormal somite development 7.39440468523612e-05 0.00110804708762198 1.0697602946866 0.556962025316456 17.2 17 2 abnormal visceral yolk sac morphology 7.39440468523612e-05 0.00110804708762198 1.0697602946866 0.556962025316456 17.2 17 2 increased circulating cholesterol level 4.3279822910547e-09 1.79430932483309e-07 1.06948401361875 0.556818181818182 17.2 17 2 hyperglycemia 2.98372243705068e-05 0.000522676729729829 1.06948401361875 0.556818181818182 17.2 17 2 decreased body weight 3.03132941464238e-55 7.54043191892293e-52 1.06740364842131 0.555735056542811 17.2 17 2 abnormal maxilla morphology 0.00105220637477608 0.0107710426224506 1.06705887980102 0.555555555555556 17.2 17 2 impaired limb coordination 0.00105220637477608 0.0107710426224506 1.06705887980102 0.555555555555556 17.2 17 2 abnormal osteoblast physiology 0.00105220637477608 0.0107710426224506 1.06705887980102 0.555555555555556 17.2 17 2 narrow eye opening 0.00697794797330085 0.0474252611573384 1.06705887980102 0.555555555555556 17.2 17 2 abnormal type II pneumocyte morphology 0.0185778281301197 0.104081863679443 1.06705887980102 0.555555555555556 17.2 17 2 abnormal bone trabecula morphology 0.0185778281301197 0.104081863679443 1.06705887980102 0.555555555555556 17.2 17 2 lowered ear position 0.0516977722914765 0.201406747964053 1.06705887980102 0.555555555555556 17.2 17 2 right pulmonary isomerism 0.0516977722914765 0.201406747964053 1.06705887980102 0.555555555555556 17.2 17 2 abnormal bile duct morphology 0.0516977722914765 0.201406747964053 1.06705887980102 0.555555555555556 17.2 17 2 increased circulating renin level 0.0516977722914765 0.201406747964053 1.06705887980102 0.555555555555556 17.2 17 2 abnormal eye anterior chamber morphology 0.0516977722914765 0.201406747964053 1.06705887980102 0.555555555555556 17.2 17 2 increased susceptibility to autoimmune disorder 0.0516977722914765 0.201406747964053 1.06705887980102 0.555555555555556 17.2 17 2 abnormal sperm axoneme morphology 0.0516977722914765 0.201406747964053 1.06705887980102 0.555555555555556 17.2 17 2 increased gastrointestinal tumor incidence 0.0516977722914765 0.201406747964053 1.06705887980102 0.555555555555556 17.2 17 2 decreased tumor latency 0.0516977722914765 0.201406747964053 1.06705887980102 0.555555555555556 17.2 17 2 atrioventricular block 0.0516977722914765 0.201406747964053 1.06705887980102 0.555555555555556 17.2 17 2 distorted hair follicle pattern 0.159094717118402 0.4341723629534 1.06705887980102 0.555555555555556 17.2 17 2 abnormal geniculate ganglion morphology 0.159094717118402 0.4341723629534 1.06705887980102 0.555555555555556 17.2 17 2 psoriasis 0.159094717118402 0.4341723629534 1.06705887980102 0.555555555555556 17.2 17 2 wavy vibrissae 0.159094717118402 0.4341723629534 1.06705887980102 0.555555555555556 17.2 17 2 multifocal hepatic necrosis 0.159094717118402 0.4341723629534 1.06705887980102 0.555555555555556 17.2 17 2 abnormal ion homeostasis 0.159094717118402 0.4341723629534 1.06705887980102 0.555555555555556 17.2 17 2 abnormal lung volume 0.159094717118402 0.4341723629534 1.06705887980102 0.555555555555556 17.2 17 2 long gestation period 0.159094717118402 0.4341723629534 1.06705887980102 0.555555555555556 17.2 17 2 abnormal posterior semicircular canal morphology 0.159094717118402 0.4341723629534 1.06705887980102 0.555555555555556 17.2 17 2 genetic imprinting 0.159094717118402 0.4341723629534 1.06705887980102 0.555555555555556 17.2 17 2 premature bone ossification 0.159094717118402 0.4341723629534 1.06705887980102 0.555555555555556 17.2 17 2 premature neuronal precursor differentiation 0.159094717118402 0.4341723629534 1.06705887980102 0.555555555555556 17.2 17 2 decreased muscle weight 0.159094717118402 0.4341723629534 1.06705887980102 0.555555555555556 17.2 17 2 abnormal bony labyrinth 0.159094717118402 0.4341723629534 1.06705887980102 0.555555555555556 17.2 17 2 small scapula 0.159094717118402 0.4341723629534 1.06705887980102 0.555555555555556 17.2 17 2 abnormal stria vascularis vasculature morphology 0.159094717118402 0.4341723629534 1.06705887980102 0.555555555555556 17.2 17 2 short frontal bone 0.159094717118402 0.4341723629534 1.06705887980102 0.555555555555556 17.2 17 2 absent adrenal gland 0.159094717118402 0.4341723629534 1.06705887980102 0.555555555555556 17.2 17 2 abnormal inguinal fat pad morphology 0.159094717118402 0.4341723629534 1.06705887980102 0.555555555555556 17.2 17 2 abnormal leukopoiesis 0.159094717118402 0.4341723629534 1.06705887980102 0.555555555555556 17.2 17 2 abnormal cerebellar layer morphology 0.159094717118402 0.4341723629534 1.06705887980102 0.555555555555556 17.2 17 2 abnormal incisor color 0.159094717118402 0.4341723629534 1.06705887980102 0.555555555555556 17.2 17 2 abnormal lung lobe morphology 0.159094717118402 0.4341723629534 1.06705887980102 0.555555555555556 17.2 17 2 trigeminal neuroma 0.159094717118402 0.4341723629534 1.06705887980102 0.555555555555556 17.2 17 2 abnormal ductus venosus valve topology 0.159094717118402 0.4341723629534 1.06705887980102 0.555555555555556 17.2 17 2 abnormal infrahyoid muscle connection 0.159094717118402 0.4341723629534 1.06705887980102 0.555555555555556 17.2 17 2 abnormal coronary sinus connection 0.159094717118402 0.4341723629534 1.06705887980102 0.555555555555556 17.2 17 2 increased bone mineralization 0.159094717118402 0.4341723629534 1.06705887980102 0.555555555555556 17.2 17 2 enhanced leukocyte tethering or rolling 0.159094717118402 0.4341723629534 1.06705887980102 0.555555555555556 17.2 17 2 adipose tissue inflammation 0.159094717118402 0.4341723629534 1.06705887980102 0.555555555555556 17.2 17 2 decreased osteoclast cell number 0.00268772985570618 0.0227793118094348 1.06705887980102 0.555555555555556 17.2 17 2 cataract 1.48726528450405e-06 3.5234022811465e-05 1.06353141242978 0.553719008264463 17.2 17 2 abnormal T-helper 1 physiology 0.00241342691632943 0.0208967929248826 1.06251820371676 0.553191489361702 17.2 17 2 insulin resistance 5.50593419045119e-07 1.41927578225361e-05 1.06220861216556 0.553030303030303 17.2 17 2 abnormal frontal bone morphology 0.00624449370542408 0.0433887656207888 1.06144278043365 0.552631578947368 17.2 17 2 incomplete somite formation 0.00624449370542408 0.0433887656207888 1.06144278043365 0.552631578947368 17.2 17 2 abnormal blood vessel morphology 1.84847402564442e-07 5.50668160334192e-06 1.05969985304378 0.551724137931034 17.2 17 2 dermatitis 0.00085187059107871 0.0089222235591928 1.05969985304378 0.551724137931034 17.2 17 2 abnormal spermiogenesis 0.00085187059107871 0.0089222235591928 1.05969985304378 0.551724137931034 17.2 17 2 lordosis 0.0165329424129614 0.0940015868622663 1.05969985304378 0.551724137931034 17.2 17 2 increased double-positive T cell number 0.0165329424129614 0.0940015868622663 1.05969985304378 0.551724137931034 17.2 17 2 increased circulating alanine transaminase level 0.000122147846964052 0.00173129783090074 1.05885073457179 0.551282051282051 17.2 17 2 increased sarcoma incidence 0.00216604786397508 0.0194163749968937 1.05834819506795 0.551020408163265 17.2 17 2 decreased circulating creatinine level 0.00216604786397508 0.0194163749968937 1.05834819506795 0.551020408163265 17.2 17 2 abnormal pericardium morphology 0.0455195605802242 0.193886826957719 1.05638829100301 0.55 17.2 17 2 abnormal vascular regression 0.0455195605802242 0.193886826957719 1.05638829100301 0.55 17.2 17 2 abnormal circulating enzyme level 0.0455195605802242 0.193886826957719 1.05638829100301 0.55 17.2 17 2 abnormal hearing physiology 0.0455195605802242 0.193886826957719 1.05638829100301 0.55 17.2 17 2 abnormal trachea morphology 0.0455195605802242 0.193886826957719 1.05638829100301 0.55 17.2 17 2 abnormal lens epithelium morphology 0.0455195605802242 0.193886826957719 1.05638829100301 0.55 17.2 17 2 abnormal optic stalk morphology 0.0455195605802242 0.193886826957719 1.05638829100301 0.55 17.2 17 2 abnormal postnatal subventricular zone morphology 0.0455195605802242 0.193886826957719 1.05638829100301 0.55 17.2 17 2 abnormal response to tactile stimuli 0.0455195605802242 0.193886826957719 1.05638829100301 0.55 17.2 17 2 perinatal lethality, complete penetrance 4.47959157200317e-10 2.37084766709742e-08 1.05503568115538 0.549295774647887 17.2 17 2 abnormal skeletal muscle fiber morphology 0.000274411575715091 0.00344746865955197 1.05503568115538 0.549295774647887 17.2 17 2 abnormal bone structure 2.90762500039857e-09 1.22588426923584e-07 1.05489551433179 0.549222797927461 17.2 17 2 abnormal gluconeogenesis 0.0019432140786734 0.017803849063352 1.05450524592101 0.549019607843137 17.2 17 2 decreased body size 1.12520491392274e-33 7.99699206680801e-31 1.05422208124703 0.548872180451128 17.2 17 2 increased lung adenoma incidence 0.0147100400178589 0.0849133219763066 1.05329037812617 0.548387096774194 17.2 17 2 seminiferous tubule degeneration 0.000246971162305373 0.00314240801143026 1.05244163487224 0.547945205479452 17.2 17 2 enlarged heart 1.12016540951425e-10 6.55626224980402e-09 1.05142094794187 0.547413793103448 17.2 17 2 abnormal coat/ hair morphology 0.00174268856723445 0.0161150104497981 1.05095233067195 0.547169811320755 17.2 17 2 abnormal placenta development 0.00174268856723445 0.0161150104497981 1.05095233067195 0.547169811320755 17.2 17 2 decreased circulating LDL cholesterol level 0.000618607591009242 0.00670495155832457 1.05038608480413 0.546875 17.2 17 2 decreased eosinophil cell number 0.000618607591009242 0.00670495155832457 1.05038608480413 0.546875 17.2 17 2 abnormal vascular development 0.000555665399666586 0.00622620577329114 1.04765780925919 0.545454545454545 17.2 17 2 abnormal head morphology 0.001562387704352 0.014749295690989 1.04765780925919 0.545454545454545 17.2 17 2 abnormal rostral-caudal axis patterning 0.001562387704352 0.014749295690989 1.04765780925919 0.545454545454545 17.2 17 2 osteoporosis 0.00446501953988193 0.034546613080735 1.04765780925919 0.545454545454545 17.2 17 2 decreased sensitivity to induced morbidity/mortality 0.00446501953988193 0.034546613080735 1.04765780925919 0.545454545454545 17.2 17 2 dilated heart atrium 0.0130868403523652 0.0793021081035528 1.04765780925919 0.545454545454545 17.2 17 2 abnormal enterocyte morphology 0.0401071572542815 0.176675914007374 1.04765780925919 0.545454545454545 17.2 17 2 abnormal tail movements 0.0401071572542815 0.176675914007374 1.04765780925919 0.545454545454545 17.2 17 2 testis hypoplasia 0.0401071572542815 0.176675914007374 1.04765780925919 0.545454545454545 17.2 17 2 abnormal chorion morphology 0.0401071572542815 0.176675914007374 1.04765780925919 0.545454545454545 17.2 17 2 abnormal sperm midpiece morphology 0.0401071572542815 0.176675914007374 1.04765780925919 0.545454545454545 17.2 17 2 abnormal cerebral cortex pyramidal cell morphology 0.0401071572542815 0.176675914007374 1.04765780925919 0.545454545454545 17.2 17 2 increased adenoma incidence 0.0401071572542815 0.176675914007374 1.04765780925919 0.545454545454545 17.2 17 2 abnormal eye distance/ position 0.136103325824247 0.384505420769805 1.04765780925919 0.545454545454545 17.2 17 2 focal hepatic necrosis 0.136103325824247 0.384505420769805 1.04765780925919 0.545454545454545 17.2 17 2 failure of somite differentiation 0.136103325824247 0.384505420769805 1.04765780925919 0.545454545454545 17.2 17 2 abnormal vestibular ganglion morphology 0.136103325824247 0.384505420769805 1.04765780925919 0.545454545454545 17.2 17 2 fatigue 0.136103325824247 0.384505420769805 1.04765780925919 0.545454545454545 17.2 17 2 fused joints 0.136103325824247 0.384505420769805 1.04765780925919 0.545454545454545 17.2 17 2 pharyngeal arch hypoplasia 0.136103325824247 0.384505420769805 1.04765780925919 0.545454545454545 17.2 17 2 enlarged placenta 0.136103325824247 0.384505420769805 1.04765780925919 0.545454545454545 17.2 17 2 abnormal spinal cord ventral horn morphology 0.136103325824247 0.384505420769805 1.04765780925919 0.545454545454545 17.2 17 2 abnormal superovulation 0.136103325824247 0.384505420769805 1.04765780925919 0.545454545454545 17.2 17 2 abnormal palate development 0.136103325824247 0.384505420769805 1.04765780925919 0.545454545454545 17.2 17 2 enhanced behavioral response to addictive substance 0.136103325824247 0.384505420769805 1.04765780925919 0.545454545454545 17.2 17 2 palatal shelf hypoplasia 0.136103325824247 0.384505420769805 1.04765780925919 0.545454545454545 17.2 17 2 decreased palatine bone horizontal plate size 0.136103325824247 0.384505420769805 1.04765780925919 0.545454545454545 17.2 17 2 aberrant origin of the right subclavian artery 0.136103325824247 0.384505420769805 1.04765780925919 0.545454545454545 17.2 17 2 common atrioventricular valve 0.136103325824247 0.384505420769805 1.04765780925919 0.545454545454545 17.2 17 2 abnormal pulmonary alveolar sac morphology 0.136103325824247 0.384505420769805 1.04765780925919 0.545454545454545 17.2 17 2 increased subcutaneous adipose tissue amount 0.136103325824247 0.384505420769805 1.04765780925919 0.545454545454545 17.2 17 2 decreased circulating alanine transaminase level 0.000498995778204909 0.00577326510830099 1.045090020511 0.544117647058823 17.2 17 2 absent vitelline blood vessels 0.00140038498945399 0.013270314900064 1.04459448233153 0.543859649122807 17.2 17 2 decreased grip strength 7.78850685502147e-10 3.7257520772819e-08 1.04367128791497 0.54337899543379 17.2 17 2 increased carcinoma incidence 0.0116425429097536 0.0711568193808653 1.04266896254843 0.542857142857143 17.2 17 2 abnormal embryonic epiblast morphology 0.0116425429097536 0.0711568193808653 1.04266896254843 0.542857142857143 17.2 17 2 decreased triglyceride level 0.0116425429097536 0.0711568193808653 1.04266896254843 0.542857142857143 17.2 17 2 increased red blood cell distribution width 0.0116425429097536 0.0711568193808653 1.04266896254843 0.542857142857143 17.2 17 2 decreased bone volume 0.0116425429097536 0.0711568193808653 1.04266896254843 0.542857142857143 17.2 17 2 curly tail 0.00356626042012015 0.0289431412562769 1.040382407806 0.541666666666667 17.2 17 2 decreased body height 0.0353637664453334 0.166132897134593 1.040382407806 0.541666666666667 17.2 17 2 curly vibrissae 0.0353637664453334 0.166132897134593 1.040382407806 0.541666666666667 17.2 17 2 hemolytic anemia 0.0353637664453334 0.166132897134593 1.040382407806 0.541666666666667 17.2 17 2 abnormal primitive streak formation 0.0353637664453334 0.166132897134593 1.040382407806 0.541666666666667 17.2 17 2 abnormal impulse conducting system conduction 0.0353637664453334 0.166132897134593 1.040382407806 0.541666666666667 17.2 17 2 increased circulating total protein level 0.0353637664453334 0.166132897134593 1.040382407806 0.541666666666667 17.2 17 2 abnormal lung development 0.000130509976008 0.00182897783278816 1.039440885265 0.541176470588235 17.2 17 2 abnormal seminiferous tubule morphology 6.3877194710426e-07 1.62137267185903e-05 1.03928611443634 0.541095890410959 17.2 17 2 azoospermia 2.13638147673069e-07 6.19973357300391e-06 1.03887241882515 0.540880503144654 17.2 17 2 small seminiferous tubules 0.000360895814881573 0.00436850773488035 1.03821945061721 0.540540540540541 17.2 17 2 increased brown adipose tissue amount 0.01035804980319 0.0652294908492029 1.03821945061721 0.540540540540541 17.2 17 2 abnormal vocalization 0.01035804980319 0.0652294908492029 1.03821945061721 0.540540540540541 17.2 17 2 abnormal liver physiology 3.84350314950317e-05 0.000639512647785227 1.03718123116659 0.54 17.2 17 2 abnormal circulating protein level 0.00318658513635768 0.0261173987699826 1.03718123116659 0.54 17.2 17 2 postnatal growth retardation 6.46813321333522e-24 2.68158022802856e-21 1.03567479510099 0.53921568627451 17.2 17 2 impaired balance 3.45571411117437e-05 0.000588773209010017 1.03567479510099 0.53921568627451 17.2 17 2 abnormal nervous system physiology 1.14079359007719e-05 0.00021912927068085 1.03551105205038 0.539130434782609 17.2 17 2 abnormal lens morphology 3.78417825367651e-06 8.20156466612444e-05 1.03538056930693 0.5390625 17.2 17 2 decreased bone mineral content 4.81057394793728e-09 1.96168896647442e-07 1.03422629888407 0.538461538461538 17.2 17 2 eyelids open at birth 0.00284710185389101 0.0240073419035725 1.03422629888407 0.538461538461538 17.2 17 2 abnormal response to injury 0.00921601578966184 0.0594678061654574 1.03422629888407 0.538461538461538 17.2 17 2 ventricular hypoplasia 0.03120382379204 0.148696382533907 1.03422629888407 0.538461538461538 17.2 17 2 absent common myeloid progenitor cells 0.117121759534012 0.345084923907871 1.03422629888407 0.538461538461538 17.2 17 2 absent myocardial trabeculae 0.117121759534012 0.345084923907871 1.03422629888407 0.538461538461538 17.2 17 2 short hair 0.117121759534012 0.345084923907871 1.03422629888407 0.538461538461538 17.2 17 2 uterus hypoplasia 0.117121759534012 0.345084923907871 1.03422629888407 0.538461538461538 17.2 17 2 abnormal digestion 0.117121759534012 0.345084923907871 1.03422629888407 0.538461538461538 17.2 17 2 increased pituitary adenoma incidence 0.117121759534012 0.345084923907871 1.03422629888407 0.538461538461538 17.2 17 2 axonal dystrophy 0.117121759534012 0.345084923907871 1.03422629888407 0.538461538461538 17.2 17 2 increased circulating ammonia level 0.117121759534012 0.345084923907871 1.03422629888407 0.538461538461538 17.2 17 2 increased renin activity 0.117121759534012 0.345084923907871 1.03422629888407 0.538461538461538 17.2 17 2 empty decidua capsularis 0.117121759534012 0.345084923907871 1.03422629888407 0.538461538461538 17.2 17 2 abnormal gut flora balance 0.117121759534012 0.345084923907871 1.03422629888407 0.538461538461538 17.2 17 2 abnormal trabecular bone morphology 9.22998181337572e-06 0.000179371716881032 1.03298473069813 0.53781512605042 17.2 17 2 decreased compact bone thickness 0.000807960655818768 0.00851611072605587 1.0320211255389 0.537313432835821 17.2 17 2 increased tumor growth/size 0.00820080221134232 0.0535419829415066 1.03062272292977 0.536585365853659 17.2 17 2 perimembraneous ventricular septal defect 0.000723540812335286 0.00770795619136627 1.02994378832968 0.536231884057971 17.2 17 2 abnormal seminal vesicle morphology 0.00227246344999058 0.0202971376368099 1.02894963409384 0.535714285714286 17.2 17 2 corneal vascularization 0.0275525337273846 0.132694922840018 1.02894963409384 0.535714285714286 17.2 17 2 decreased percent body fat/body weight 0.000580114166309946 0.00638510614467253 1.02613059400044 0.534246575342466 17.2 17 2 teratozoospermia 0.000168594388694639 0.00225472334342965 1.02583160489962 0.534090909090909 17.2 17 2 abnormal eating behavior 0.00181369345543763 0.0167094906311152 1.02437652460898 0.533333333333333 17.2 17 2 increased metastatic potential 0.0243448626670485 0.118508504665916 1.02437652460898 0.533333333333333 17.2 17 2 abnormal optic cup morphology 0.0243448626670485 0.118508504665916 1.02437652460898 0.533333333333333 17.2 17 2 abnormal prostate gland morphology 0.101247368909362 0.343826389299712 1.02437652460898 0.533333333333333 17.2 17 2 placental labyrinth hypoplasia 0.101247368909362 0.343826389299712 1.02437652460898 0.533333333333333 17.2 17 2 abnormal cricoid cartilage morphology 0.101247368909362 0.343826389299712 1.02437652460898 0.533333333333333 17.2 17 2 dilated ureter 0.101247368909362 0.343826389299712 1.02437652460898 0.533333333333333 17.2 17 2 abnormal energy homeostasis 0.101247368909362 0.343826389299712 1.02437652460898 0.533333333333333 17.2 17 2 abnormal cerebral aqueduct morphology 0.101247368909362 0.343826389299712 1.02437652460898 0.533333333333333 17.2 17 2 abnormal branching involved in lung morphogenesis 0.101247368909362 0.343826389299712 1.02437652460898 0.533333333333333 17.2 17 2 increased susceptibility to parasitic infection 0.000151167750583435 0.0020436401063929 1.02437652460898 0.533333333333333 17.2 17 2 abnormal ectoderm development 0.00649620775036846 0.0447626503574558 1.02437652460898 0.533333333333333 17.2 17 2 small placenta 0.00649620775036846 0.0447626503574558 1.02437652460898 0.533333333333333 17.2 17 2 cardiomyopathy 0.00649620775036846 0.0447626503574558 1.02437652460898 0.533333333333333 17.2 17 2 increased circulating glucose level 2.85671757252036e-06 6.34471871575392e-05 1.02165211895843 0.531914893617021 17.2 17 2 hepatic necrosis 0.00578310255117998 0.0405795982963616 1.02165211895843 0.531914893617021 17.2 17 2 postnatal lethality, incomplete penetrance 8.83236172211396e-21 2.19704997837585e-18 1.0212204349645 0.53169014084507 17.2 17 2 decreased circulating HDL cholesterol level 8.58253783213593e-06 0.000168102857145182 1.02037505380973 0.53125 17.2 17 2 scoliosis 0.0215243941030612 0.112601325618012 1.02037505380973 0.53125 17.2 17 2 polydactyly 9.76490828987635e-05 0.00143729049532943 1.01915011376914 0.530612244897959 17.2 17 2 cardiac hypertrophy 9.76490828987635e-05 0.00143729049532943 1.01915011376914 0.530612244897959 17.2 17 2 abnormal long bone hypertrophic chondrocyte zone 0.00514910939663196 0.0367003141092321 1.01915011376914 0.530612244897959 17.2 17 2 increased fluid intake 0.00514910939663196 0.0367003141092321 1.01915011376914 0.530612244897959 17.2 17 2 respiratory failure 1.67114807700035e-06 3.9402662005103e-05 1.01759257411488 0.529801324503311 17.2 17 2 small lung 0.0045853775762525 0.0351266458944082 1.01684434428098 0.529411764705882 17.2 17 2 short maxilla 0.0190422169590212 0.105731059565994 1.01684434428098 0.529411764705882 17.2 17 2 abnormal endoderm development 0.0190422169590212 0.105731059565994 1.01684434428098 0.529411764705882 17.2 17 2 increased susceptibility to viral infection induced morbidity/mortality 0.0190422169590212 0.105731059565994 1.01684434428098 0.529411764705882 17.2 17 2 increased incidence of corneal inflammation 0.0878440489601005 0.31440585868813 1.01684434428098 0.529411764705882 17.2 17 2 abnormal cranial suture morphology 0.0878440489601005 0.31440585868813 1.01684434428098 0.529411764705882 17.2 17 2 abnormal glutamate-mediated receptor currents 0.0878440489601005 0.31440585868813 1.01684434428098 0.529411764705882 17.2 17 2 decreased vasoconstriction 0.0878440489601005 0.31440585868813 1.01684434428098 0.529411764705882 17.2 17 2 pancytopenia 0.0878440489601005 0.31440585868813 1.01684434428098 0.529411764705882 17.2 17 2 enhanced behavioral response to cocaine 0.0878440489601005 0.31440585868813 1.01684434428098 0.529411764705882 17.2 17 2 increased circulating magnesium level 0.0878440489601005 0.31440585868813 1.01684434428098 0.529411764705882 17.2 17 2 decreased body fat mass 0.0878440489601005 0.31440585868813 1.01684434428098 0.529411764705882 17.2 17 2 domed cranium 0.00103247963883444 0.0106789733954289 1.01523030563926 0.528571428571429 17.2 17 2 abnormal mesoderm development 0.0040840447349464 0.0322580277198366 1.01471259513154 0.528301886792453 17.2 17 2 short snout 5.64986718158903e-05 0.000906712555755014 1.01370593581097 0.527777777777778 17.2 17 2 heart right ventricle hypertrophy 0.0168559137210832 0.0956193509263272 1.01370593581097 0.527777777777778 17.2 17 2 renal hypoplasia 0.0168559137210832 0.0956193509263272 1.01370593581097 0.527777777777778 17.2 17 2 increased circulating calcium level 0.00363813044809728 0.029478337099811 1.01273588228388 0.527272727272727 17.2 17 2 abnormal spermatogenesis 1.91521680638996e-07 5.67154976892264e-06 1.01254608920249 0.527173913043478 17.2 17 2 lethargy 0.000191835362612995 0.0025181554854872 1.01198487310162 0.526881720430108 17.2 17 2 abnormal neuron differentiation 4.53848114002934e-05 0.000747647141445231 1.01180047352561 0.526785714285714 17.2 17 2 kyphosis 2.61746524198172e-06 5.83941236720137e-05 1.01157181805137 0.526666666666667 17.2 17 2 alopecia 0.000171733427542701 0.00228442193054796 1.01089788612729 0.526315789473684 17.2 17 2 decreased total retina thickness 0.0149286676895966 0.0858614124343852 1.01089788612729 0.526315789473684 17.2 17 2 short vibrissae 0.076443462553734 0.281083685295511 1.01089788612729 0.526315789473684 17.2 17 2 abnormal stationary movement 0.076443462553734 0.281083685295511 1.01089788612729 0.526315789473684 17.2 17 2 stereotypic behavior 0.076443462553734 0.281083685295511 1.01089788612729 0.526315789473684 17.2 17 2 delayed sexual maturation 0.076443462553734 0.281083685295511 1.01089788612729 0.526315789473684 17.2 17 2 abnormal ear morphology 0.076443462553734 0.281083685295511 1.01089788612729 0.526315789473684 17.2 17 2 increased susceptibility to ischemic brain injury 0.076443462553734 0.281083685295511 1.01089788612729 0.526315789473684 17.2 17 2 oliguria 0.076443462553734 0.281083685295511 1.01089788612729 0.526315789473684 17.2 17 2 decreased eye pigmentation 0.076443462553734 0.281083685295511 1.01089788612729 0.526315789473684 17.2 17 2 decreased liver regeneration 0.076443462553734 0.281083685295511 1.01089788612729 0.526315789473684 17.2 17 2 Leydig cell hypoplasia 0.076443462553734 0.281083685295511 1.01089788612729 0.526315789473684 17.2 17 2 shortened RR interval 0.076443462553734 0.281083685295511 1.01089788612729 0.526315789473684 17.2 17 2 embryonic lethality between implantation and somite formation, incomplete penetrance 0.076443462553734 0.281083685295511 1.01089788612729 0.526315789473684 17.2 17 2 decreased body length 3.25373102254019e-10 1.76592091176524e-08 1.00942212278987 0.525547445255474 17.2 17 2 abnormal pancreas morphology 0.0117275420486123 0.071500639328243 1.00608408666954 0.523809523809524 17.2 17 2 abnormal reproductive system morphology 0.0117275420486123 0.071500639328243 1.00608408666954 0.523809523809524 17.2 17 2 increased bone ossification 0.066689445101377 0.251899704418929 1.00608408666954 0.523809523809524 17.2 17 2 abnormal retina morphology 4.72735745077749e-08 1.52718203361156e-06 1.00608408666954 0.523809523809524 17.2 17 2 skin lesions 0.00229476431330429 0.0202988744114171 1.00608408666954 0.523809523809524 17.2 17 2 postnatal lethality, complete penetrance 1.72055912612674e-13 1.55632393681464e-11 1.00513629195765 0.523316062176166 17.2 17 2 increased sensitivity to induced morbidity/mortality 4.14594305268979e-07 1.11492252362874e-05 1.00210746972618 0.521739130434783 17.2 17 2 abnormal skeleton morphology 5.68107615249162e-05 0.000908789513139736 1.00210746972618 0.521739130434783 17.2 17 2 abnormal postnatal growth 0.0583043649811233 0.225030423414343 1.00210746972618 0.521739130434783 17.2 17 2 abnormal corneal stroma morphology 0.0583043649811233 0.225030423414343 1.00210746972618 0.521739130434783 17.2 17 2 decreased effector memory CD8-positive, alpha-beta T cell number 0.0583043649811233 0.225030423414343 1.00210746972618 0.521739130434783 17.2 17 2 male infertility 9.95443933429584e-17 1.70770123062489e-14 1.00044725191682 0.520874751491054 17.2 17 2 overriding aortic valve 0.00819271356320157 0.0535419829415066 1.00036769981346 0.520833333333333 17.2 17 2 abnormal lymph node morphology 0.00819271356320157 0.0535419829415066 1.00036769981346 0.520833333333333 17.2 17 2 kidney inflammation 0.0072751773452624 0.0491766403433158 0.998767111493758 0.52 17.2 17 2 decreased circulating alkaline phosphatase level 0.0072751773452624 0.0491766403433158 0.998767111493758 0.52 17.2 17 2 increased circulating chloride level 0.0072751773452624 0.0491766403433158 0.998767111493758 0.52 17.2 17 2 diaphragmatic hernia 0.0510675873781221 0.200521899925933 0.998767111493758 0.52 17.2 17 2 delayed bone ossification 0.00115478771179102 0.0114901377323206 0.998767111493758 0.52 17.2 17 2 reduced male fertility 2.75731971864516e-08 9.33174530629911e-07 0.998428661100165 0.519823788546256 17.2 17 2 abnormal snout morphology 0.00646271535640289 0.0447176757970854 0.997289645352495 0.519230769230769 17.2 17 2 abnormal hair growth 0.00646271535640289 0.0447176757970854 0.997289645352495 0.519230769230769 17.2 17 2 abnormal female meiosis 0.00646271535640289 0.0447176757970854 0.997289645352495 0.519230769230769 17.2 17 2 abnormal chondrocyte morphology 0.00574293362282664 0.040411732352988 0.995921621147622 0.518518518518518 17.2 17 2 abnormal small intestine morphology 0.00574293362282664 0.040411732352988 0.995921621147622 0.518518518518518 17.2 17 2 wrinkled skin 0.0448010498894927 0.192308216738763 0.995921621147622 0.518518518518518 17.2 17 2 cardiac fibrosis 0.000653968039282708 0.00704218830179973 0.994247803296954 0.517647058823529 17.2 17 2 seizures 8.78827856104334e-05 0.00130903251021529 0.994049588025164 0.517543859649123 17.2 17 2 abnormal retinal pigmentation 0.00058387610855478 0.00639820185035249 0.993468612228539 0.517241379310345 17.2 17 2 glomerulosclerosis 0.00453923816411663 0.0350663196684476 0.993468612228539 0.517241379310345 17.2 17 2 focal hair loss 0.0393592387071235 0.176675914007374 0.993468612228539 0.517241379310345 17.2 17 2 decreased rib number 0.000521353678520961 0.00599014907769465 0.992724440983424 0.51685393258427 17.2 17 2 decreased birth weight 0.00037139739229479 0.00447385478611762 0.99067992840474 0.515789473684211 17.2 17 2 decreased caudal vertebrae number 0.00319657820296191 0.0261562114469334 0.990364022815325 0.515625 17.2 17 2 abnormal motor coordination/ balance 0.000296384666278758 0.0036051680066915 0.989454597633676 0.515151515151515 17.2 17 2 abnormal skin morphology 0.00284540034234498 0.0240073419035725 0.989454597633676 0.515151515151515 17.2 17 2 abnormal QRS complex 0.0304892949631757 0.145850233117115 0.989454597633676 0.515151515151515 17.2 17 2 decreased susceptibility to injury 0.00253340506725431 0.0215447695890431 0.988598668050948 0.514705882352941 17.2 17 2 decreased circulating thyroxine level 0.0268771659523634 0.130071887755844 0.987791648730091 0.514285714285714 17.2 17 2 malocclusion 0.0237147700788593 0.115894873420752 0.986308478086351 0.513513513513513 17.2 17 2 abnormal breathing pattern 0.0237147700788593 0.115894873420752 0.986308478086351 0.513513513513513 17.2 17 2 abnormal hair follicle development 0.0237147700788593 0.115894873420752 0.986308478086351 0.513513513513513 17.2 17 2 failure of heart looping 0.0209419854790017 0.110017294359064 0.984977427508637 0.512820512820513 17.2 17 2 abnormal retinal pigment epithelium morphology 0.00126763243072051 0.012127829505451 0.984361816616444 0.5125 17.2 17 2 abnormal response/metabolism to endogenous compounds 0.00113021043011292 0.0113040337672407 0.983776235523871 0.51219512195122 17.2 17 2 scaly skin 0.0185075579389789 0.10392223560544 0.983776235523871 0.51219512195122 17.2 17 2 liver fibrosis 0.0185075579389789 0.10392223560544 0.983776235523871 0.51219512195122 17.2 17 2 hypoactivity 7.88195606423362e-12 5.29901775940031e-10 0.983279190564657 0.511936339522546 17.2 17 2 delayed endochondral bone ossification 0.016367616674249 0.0932747914712355 0.982686782328384 0.511627906976744 17.2 17 2 altered response to myocardial infarction 0.0144844775900289 0.0842810245735602 0.981694169416942 0.511111111111111 17.2 17 2 abnormal ovarian follicle morphology 0.0144844775900289 0.0842810245735602 0.981694169416942 0.511111111111111 17.2 17 2 abnormal metabolism 0.0144844775900289 0.0842810245735602 0.981694169416942 0.511111111111111 17.2 17 2 lethality at weaning, complete penetrance 0.0144844775900289 0.0842810245735602 0.981694169416942 0.511111111111111 17.2 17 2 increased circulating triglyceride level 2.26163406414599e-05 0.000409150162513683 0.980222364065492 0.510344827586207 17.2 17 2 increased blood urea nitrogen level 2.26163406414599e-05 0.000409150162513683 0.980222364065492 0.510344827586207 17.2 17 2 abnormal response to novel object 0.0100725691050328 0.0635926793115966 0.979183442640939 0.509803921568627 17.2 17 2 abnormal joint morphology 0.00792569247069417 0.0524613456399883 0.977813955308574 0.509090909090909 17.2 17 2 increased body weight 2.01970715018873e-07 5.94558761667986e-06 0.977502152389152 0.508928571428571 17.2 17 2 abnormal male meiosis 0.00554916635531834 0.0393028394123368 0.976096483490117 0.508196721311475 17.2 17 2 abnormal gait 1.34437462814518e-09 5.97166408484131e-08 0.975892684245208 0.508090614886731 17.2 17 2 no abnormal phenotype detected 2.42028433287777e-47 2.00681909267782e-44 0.973083896035262 0.506628242074928 17.2 17 2 increased circulating insulin level 1.40262491903955e-05 0.000268386883546991 0.972357404218683 0.50625 17.2 17 2 small ovary 0.000970675785789402 0.0100606500714631 0.970906321401371 0.505494505494505 17.2 17 2 impaired righting response 0.000772043440602638 0.00817216195105984 0.970461970682194 0.505263157894737 17.2 17 2 cyanosis 2.38056652318054e-06 5.35896762571185e-05 0.970356668819056 0.505208333333333 17.2 17 2 abnormal testis morphology 0.000247793861919327 0.00314483281389963 0.968703887401973 0.504347826086956 17.2 17 2 decreased bone mineral density 4.03870692442165e-08 1.32187940453932e-06 0.967573691007545 0.503759398496241 17.2 17 2 microphthalmia 2.93729523421529e-05 0.000516361971385904 0.966629808760927 0.503267973856209 17.2 17 2 abnormal blood homeostasis 0.00037127950938368 0.00447385478611762 0.960352991820921 0.5 17.2 17 2 decreased exploration in new environment 0.0020672714627774 0.0187398372836528 0.960352991820921 0.5 17.2 17 2 increased food intake 0.0020672714627774 0.0187398372836528 0.960352991820921 0.5 17.2 17 2 abnormal tooth morphology 0.00666556030324541 0.0458660615610594 0.960352991820921 0.5 17.2 17 2 abnormal incisor morphology 0.00845646994448857 0.055066672740616 0.960352991820921 0.5 17.2 17 2 decreased respiratory quotient 0.0154510917948275 0.0887634892370286 0.960352991820921 0.5 17.2 17 2 abnormal circadian rhythm 0.0223336492320732 0.113842183727347 0.960352991820921 0.5 17.2 17 2 abnormal amino acid level 0.0223336492320732 0.113842183727347 0.960352991820921 0.5 17.2 17 2 lethality, incomplete penetrance 0.0223336492320732 0.113842183727347 0.960352991820921 0.5 17.2 17 2 spina bifida 0.0252875738293454 0.122977204106543 0.960352991820921 0.5 17.2 17 2 decreased threshold for auditory brainstem response 0.0325008724681221 0.154729033998954 0.960352991820921 0.5 17.2 17 2 head tilt 0.0368984181836439 0.17236585020059 0.960352991820921 0.5 17.2 17 2 pancreatic islet hyperplasia 0.0477196195493068 0.199151518008184 0.960352991820921 0.5 17.2 17 2 delayed eyelid opening 0.0543736147471986 0.211500182460761 0.960352991820921 0.5 17.2 17 2 abnormal response to new environment 0.0543736147471986 0.211500182460761 0.960352991820921 0.5 17.2 17 2 small superior cervical ganglion 0.062049566051601 0.237276395931372 0.960352991820921 0.5 17.2 17 2 abnormal somite shape 0.062049566051601 0.237276395931372 0.960352991820921 0.5 17.2 17 2 abnormal hormone level 0.062049566051601 0.237276395931372 0.960352991820921 0.5 17.2 17 2 hypoxia 0.062049566051601 0.237276395931372 0.960352991820921 0.5 17.2 17 2 abnormal renal tubule epithelium morphology 0.062049566051601 0.237276395931372 0.960352991820921 0.5 17.2 17 2 prolonged QRS complex duration 0.062049566051601 0.237276395931372 0.960352991820921 0.5 17.2 17 2 abnormal abdominal fat pad morphology 0.0932717329484727 0.33073903878735 0.960352991820921 0.5 17.2 17 2 increased body size 0.0932717329484727 0.33073903878735 0.960352991820921 0.5 17.2 17 2 increased coping response 0.0932717329484727 0.33073903878735 0.960352991820921 0.5 17.2 17 2 abnormal cochlear sensory epithelium morphology 0.0932717329484727 0.33073903878735 0.960352991820921 0.5 17.2 17 2 decreased cardiac output 0.0932717329484727 0.33073903878735 0.960352991820921 0.5 17.2 17 2 abnormal female reproductive system physiology 0.0932717329484727 0.33073903878735 0.960352991820921 0.5 17.2 17 2 abnormal circulating lipid level 0.0932717329484727 0.33073903878735 0.960352991820921 0.5 17.2 17 2 abnormal occipital bone morphology 0.0932717329484727 0.33073903878735 0.960352991820921 0.5 17.2 17 2 abnormal temporal bone morphology 0.0932717329484727 0.33073903878735 0.960352991820921 0.5 17.2 17 2 increased circulating creatine kinase level 0.0932717329484727 0.33073903878735 0.960352991820921 0.5 17.2 17 2 rough coat 0.0932717329484727 0.33073903878735 0.960352991820921 0.5 17.2 17 2 cortical renal glomerulopathies 0.123990325628724 0.355534219021847 0.960352991820921 0.5 17.2 17 2 thick dermal layer 0.123990325628724 0.355534219021847 0.960352991820921 0.5 17.2 17 2 eye inflammation 0.123990325628724 0.355534219021847 0.960352991820921 0.5 17.2 17 2 abnormal thyroid cartilage morphology 0.123990325628724 0.355534219021847 0.960352991820921 0.5 17.2 17 2 abnormal thymus cortex morphology 0.123990325628724 0.355534219021847 0.960352991820921 0.5 17.2 17 2 long tibia 0.123990325628724 0.355534219021847 0.960352991820921 0.5 17.2 17 2 jerky movement 0.123990325628724 0.355534219021847 0.960352991820921 0.5 17.2 17 2 decreased lactate dehydrogenase level 0.123990325628724 0.355534219021847 0.960352991820921 0.5 17.2 17 2 abnormal tympanic ring morphology 0.14374594501181 0.402666709703692 0.960352991820921 0.5 17.2 17 2 reduced male mating frequency 0.14374594501181 0.402666709703692 0.960352991820921 0.5 17.2 17 2 small epididymis 0.14374594501181 0.402666709703692 0.960352991820921 0.5 17.2 17 2 abnormal amnion morphology 0.14374594501181 0.402666709703692 0.960352991820921 0.5 17.2 17 2 decreased circulating growth hormone level 0.14374594501181 0.402666709703692 0.960352991820921 0.5 17.2 17 2 loose skin 0.14374594501181 0.402666709703692 0.960352991820921 0.5 17.2 17 2 decreased circulating triiodothyronine level 0.14374594501181 0.402666709703692 0.960352991820921 0.5 17.2 17 2 decreased creatinine clearance 0.14374594501181 0.402666709703692 0.960352991820921 0.5 17.2 17 2 kidney degeneration 0.14374594501181 0.402666709703692 0.960352991820921 0.5 17.2 17 2 increased heart left ventricle size 0.14374594501181 0.402666709703692 0.960352991820921 0.5 17.2 17 2 midline facial cleft 0.167458451705499 0.449841143215366 0.960352991820921 0.5 17.2 17 2 absent atrioventricular cushions 0.167458451705499 0.449841143215366 0.960352991820921 0.5 17.2 17 2 megacephaly 0.167458451705499 0.449841143215366 0.960352991820921 0.5 17.2 17 2 translucent skin 0.167458451705499 0.449841143215366 0.960352991820921 0.5 17.2 17 2 absent visceral yolk sac blood islands 0.167458451705499 0.449841143215366 0.960352991820921 0.5 17.2 17 2 abnormal ventral body wall morphology 0.167458451705499 0.449841143215366 0.960352991820921 0.5 17.2 17 2 abnormal decidualization 0.167458451705499 0.449841143215366 0.960352991820921 0.5 17.2 17 2 skeletal muscle necrosis 0.167458451705499 0.449841143215366 0.960352991820921 0.5 17.2 17 2 abnormal pancreas development 0.167458451705499 0.449841143215366 0.960352991820921 0.5 17.2 17 2 increased circulating growth hormone level 0.167458451705499 0.449841143215366 0.960352991820921 0.5 17.2 17 2 improved glucose tolerance 3.79167813710276e-06 8.20156466612444e-05 0.960352991820921 0.5 17.2 17 2 abnormal cranium morphology 0.00012008227547522 0.00170688377282635 0.960352991820921 0.5 17.2 17 2 abnormal intestine morphology 0.00369912245204619 0.0298363956867516 0.960352991820921 0.5 17.2 17 2 abnormal skin pigmentation 0.0286554830258625 0.137873334674725 0.960352991820921 0.5 17.2 17 2 abnormal spleen red pulp morphology 0.0419363729673304 0.182691292042442 0.960352991820921 0.5 17.2 17 2 abnormal nervous system development 0.0419363729673304 0.182691292042442 0.960352991820921 0.5 17.2 17 2 increased susceptibility to otitis media 0.0709313509642044 0.266729758916793 0.960352991820921 0.5 17.2 17 2 abnormal Mullerian duct morphology 0.0709313509642044 0.266729758916793 0.960352991820921 0.5 17.2 17 2 abnormal cell proliferation 0.107367364527243 0.345084923907871 0.960352991820921 0.5 17.2 17 2 increased urine glucose level 0.107367364527243 0.345084923907871 0.960352991820921 0.5 17.2 17 2 abnormal hair texture 0.107367364527243 0.345084923907871 0.960352991820921 0.5 17.2 17 2 abnormal incus morphology 0.107367364527243 0.345084923907871 0.960352991820921 0.5 17.2 17 2 absent ductus venosus valve 0.107367364527243 0.345084923907871 0.960352991820921 0.5 17.2 17 2 abnormal otic capsule morphology 0.232007569591749 0.563042760350708 0.960352991820921 0.5 17.2 17 2 jaundice 0.232007569591749 0.563042760350708 0.960352991820921 0.5 17.2 17 2 abnormal prostate gland epithelium morphology 0.232007569591749 0.563042760350708 0.960352991820921 0.5 17.2 17 2 abnormal gland morphology 0.232007569591749 0.563042760350708 0.960352991820921 0.5 17.2 17 2 ketoaciduria 0.232007569591749 0.563042760350708 0.960352991820921 0.5 17.2 17 2 impaired basement membrane formation 0.232007569591749 0.563042760350708 0.960352991820921 0.5 17.2 17 2 abnormal tibialis anterior morphology 0.232007569591749 0.563042760350708 0.960352991820921 0.5 17.2 17 2 rickets 0.232007569591749 0.563042760350708 0.960352991820921 0.5 17.2 17 2 aneurysm 0.232007569591749 0.563042760350708 0.960352991820921 0.5 17.2 17 2 absent seminal vesicle 0.232007569591749 0.563042760350708 0.960352991820921 0.5 17.2 17 2 increased atrioventricular cushion size 0.232007569591749 0.563042760350708 0.960352991820921 0.5 17.2 17 2 increased left ventricle diastolic pressure 0.232007569591749 0.563042760350708 0.960352991820921 0.5 17.2 17 2 abnormal reproductive system development 0.232007569591749 0.563042760350708 0.960352991820921 0.5 17.2 17 2 abnormal respiratory conducting tube morphology 0.232007569591749 0.563042760350708 0.960352991820921 0.5 17.2 17 2 decreased cochlear inner hair cell number 0.232007569591749 0.563042760350708 0.960352991820921 0.5 17.2 17 2 tachypnea 0.232007569591749 0.563042760350708 0.960352991820921 0.5 17.2 17 2 abnormal developmental vascular remodeling 0.232007569591749 0.563042760350708 0.960352991820921 0.5 17.2 17 2 abnormal hippocampus neuron morphology 0.232007569591749 0.563042760350708 0.960352991820921 0.5 17.2 17 2 abnormal cerebellar granule cell migration 0.232007569591749 0.563042760350708 0.960352991820921 0.5 17.2 17 2 increased T-helper 17 cell number 0.232007569591749 0.563042760350708 0.960352991820921 0.5 17.2 17 2 abnormal vibrissa follicle morphology 0.232007569591749 0.563042760350708 0.960352991820921 0.5 17.2 17 2 abnormal heart and great artery attachment 0.232007569591749 0.563042760350708 0.960352991820921 0.5 17.2 17 2 thick aortic valve 0.232007569591749 0.563042760350708 0.960352991820921 0.5 17.2 17 2 sinus bradycardia 0.232007569591749 0.563042760350708 0.960352991820921 0.5 17.2 17 2 abnormal circadian temperature homeostasis 0.232007569591749 0.563042760350708 0.960352991820921 0.5 17.2 17 2 increased fatty acid oxidation 0.232007569591749 0.563042760350708 0.960352991820921 0.5 17.2 17 2 abnormal startle reflex 0.0812449635169131 0.2978582855539 0.960352991820921 0.5 17.2 17 2 apnea 0.0812449635169131 0.2978582855539 0.960352991820921 0.5 17.2 17 2 prolonged QT interval 0.0812449635169131 0.2978582855539 0.960352991820921 0.5 17.2 17 2 abnormal supraoccipital bone morphology 0.196296226145401 0.506784496664955 0.960352991820921 0.5 17.2 17 2 abnormal mineral level 0.196296226145401 0.506784496664955 0.960352991820921 0.5 17.2 17 2 abnormal AMPA-mediated synaptic currents 0.196296226145401 0.506784496664955 0.960352991820921 0.5 17.2 17 2 decreased synaptic depression 0.196296226145401 0.506784496664955 0.960352991820921 0.5 17.2 17 2 small intestinal inflammation 0.196296226145401 0.506784496664955 0.960352991820921 0.5 17.2 17 2 abnormal vascular endothelial cell development 0.196296226145401 0.506784496664955 0.960352991820921 0.5 17.2 17 2 delayed somite formation 0.196296226145401 0.506784496664955 0.960352991820921 0.5 17.2 17 2 increased hepatocyte proliferation 0.196296226145401 0.506784496664955 0.960352991820921 0.5 17.2 17 2 stria vascularis degeneration 0.196296226145401 0.506784496664955 0.960352991820921 0.5 17.2 17 2 hematuria 0.196296226145401 0.506784496664955 0.960352991820921 0.5 17.2 17 2 abnormal somatic nervous system physiology 0.196296226145401 0.506784496664955 0.960352991820921 0.5 17.2 17 2 hemoperitoneum 0.196296226145401 0.506784496664955 0.960352991820921 0.5 17.2 17 2 reduced cerebellar foliation 0.196296226145401 0.506784496664955 0.960352991820921 0.5 17.2 17 2 decreased oligodendrocyte number 0.196296226145401 0.506784496664955 0.960352991820921 0.5 17.2 17 2 decreased prostaglandin level 0.196296226145401 0.506784496664955 0.960352991820921 0.5 17.2 17 2 increased type II pneumocyte number 0.196296226145401 0.506784496664955 0.960352991820921 0.5 17.2 17 2 neonatal lethality, complete penetrance 4.58688026967293e-12 3.21404638614406e-10 0.956140917295391 0.49780701754386 17.2 17 2 cleft palate 0.000199398655868605 0.00259818149570633 0.953022052952059 0.49618320610687 17.2 17 2 abnormal lung morphology 0.000392688563676969 0.00469621539493491 0.952282798612342 0.495798319327731 17.2 17 2 decreased startle reflex 0.000439807067641386 0.00522205289144605 0.952144846591683 0.495726495726496 17.2 17 2 infertility 0.000776464938026189 0.00820151394199637 0.951377730215118 0.495327102803738 17.2 17 2 abnormal myocardial fiber morphology 0.00137562044728247 0.0130605185595998 0.950452445513489 0.494845360824742 17.2 17 2 abnormal muscle physiology 0.00218031202044436 0.0195090868735804 0.949562508766754 0.49438202247191 17.2 17 2 abnormal skeleton development 0.00346700105614848 0.0281835461672201 0.948496782045354 0.493827160493827 17.2 17 2 abnormal ovary morphology 0.00622582462686895 0.043380220614388 0.94682689334457 0.492957746478873 17.2 17 2 corneal opacity 0.00622582462686895 0.043380220614388 0.94682689334457 0.492957746478873 17.2 17 2 hyperkeratosis 0.00700538539165834 0.0475467835245569 0.946434832519169 0.492753623188406 17.2 17 2 abnormal long bone morphology 0.0112699895469114 0.0693055599454688 0.944609500151726 0.491803278688525 17.2 17 2 abnormal kidney morphology 3.28125864961983e-05 0.000564295890285761 0.94388979767542 0.491428571428571 17.2 17 2 abnormal craniofacial bone morphology 0.0143298441274864 0.0837731780660927 0.9435046937188 0.491228070175439 17.2 17 2 abnormal facial morphology 0.0143298441274864 0.0837731780660927 0.9435046937188 0.491228070175439 17.2 17 2 abnormal pancreatic islet morphology 0.0182560631554932 0.102741984387533 0.942233124050715 0.490566037735849 17.2 17 2 cachexia 0.00128356985879318 0.0122567371353092 0.941884665055134 0.490384615384615 17.2 17 2 abnormal dendritic spine morphology 0.0206227482273226 0.110017294359064 0.941522541000903 0.490196078431373 17.2 17 2 absent kidney 0.0233102962463032 0.115050600134023 0.940753951171515 0.489795918367347 17.2 17 2 abnormal tibia morphology 0.0263652350080515 0.127718640861788 0.939919949441753 0.48936170212766 17.2 17 2 abnormal male reproductive system morphology 0.033802078386483 0.159852984764974 0.938019201313458 0.488372093023256 17.2 17 2 kidney failure 0.033802078386483 0.159852984764974 0.938019201313458 0.488372093023256 17.2 17 2 abnormal mammary gland development 0.0383201735847996 0.176675914007374 0.936929748117972 0.48780487804878 17.2 17 2 decreased litter size 3.38360030448179e-07 9.24912720593237e-06 0.936429607683034 0.487544483985765 17.2 17 2 abnormal posture 0.00512108793562438 0.0366054777007634 0.936344167025398 0.4875 17.2 17 2 absent gastric milk in neonates 0.0057549990254444 0.0404394352423529 0.935728556133205 0.487179487179487 17.2 17 2 abnormal iris morphology 0.0434818151077862 0.188927537258722 0.935728556133205 0.487179487179487 17.2 17 2 increased white adipose tissue amount 0.0493881900723872 0.199151518008184 0.934397505555491 0.486486486486487 17.2 17 2 abnormal humerus morphology 0.0493881900723872 0.199151518008184 0.934397505555491 0.486486486486487 17.2 17 2 abnormal neuromuscular synapse morphology 0.00818103426801505 0.0535419829415066 0.933676519825896 0.486111111111111 17.2 17 2 impaired fertilization 0.00920425742089855 0.0594678061654574 0.932914334911752 0.485714285714286 17.2 17 2 abnormal artery morphology 0.0561589573703545 0.218103679092517 0.932914334911752 0.485714285714286 17.2 17 2 decreased bone mineralization 0.0561589573703545 0.218103679092517 0.932914334911752 0.485714285714286 17.2 17 2 increased total body fat amount 0.000445337929633129 0.00523920078975274 0.931685738333729 0.485074626865672 17.2 17 2 abnormal ovarian folliculogenesis 0.0639363956303713 0.243555565284148 0.931251386008166 0.484848484848485 17.2 17 2 single kidney 0.0639363956303713 0.243555565284148 0.931251386008166 0.484848484848485 17.2 17 2 abnormal eyelid morphology 0.0728907471731499 0.273684126178431 0.929373863052504 0.483870967741935 17.2 17 2 abnormal postnatal growth/weight/body size 0.0728907471731499 0.273684126178431 0.929373863052504 0.483870967741935 17.2 17 2 cochlear ganglion degeneration 0.0188089304009266 0.105139807578214 0.927237371413303 0.482758620689655 17.2 17 2 abnormal enzyme/coenzyme level 0.0188089304009266 0.105139807578214 0.927237371413303 0.482758620689655 17.2 17 2 abnormal circulating glucose level 0.0832272049064464 0.303782350997484 0.927237371413303 0.482758620689655 17.2 17 2 abnormal outer ear morphology 0.0832272049064464 0.303782350997484 0.927237371413303 0.482758620689655 17.2 17 2 impaired coordination 4.51732018784715e-08 1.46886718526402e-06 0.927045951642161 0.482658959537572 17.2 17 2 increased cell proliferation 0.0239512240178044 0.116935563776818 0.92478436249422 0.481481481481481 17.2 17 2 abnormal heart valve morphology 0.095195201962151 0.332929461462586 0.92478436249422 0.481481481481481 17.2 17 2 thin epidermis 0.095195201962151 0.332929461462586 0.92478436249422 0.481481481481481 17.2 17 2 abnormal palate morphology 0.095195201962151 0.332929461462586 0.92478436249422 0.481481481481481 17.2 17 2 decreased bone ossification 0.095195201962151 0.332929461462586 0.92478436249422 0.481481481481481 17.2 17 2 absent corpus luteum 0.0270489754251558 0.130649177417621 0.923416338289347 0.480769230769231 17.2 17 2 decreased kidney weight 0.0270489754251558 0.130649177417621 0.923416338289347 0.480769230769231 17.2 17 2 obese 0.00840320316385666 0.0547915278377286 0.922936641490236 0.480519480519481 17.2 17 2 kinked tail 0.00271750761140098 0.022992517630476 0.922692090180885 0.480392156862745 17.2 17 2 abnormal primitive streak morphology 0.109101003029643 0.345084923907871 0.921938872148084 0.48 17.2 17 2 increased pre-B cell number 0.109101003029643 0.345084923907871 0.921938872148084 0.48 17.2 17 2 abnormal energy expenditure 0.109101003029643 0.345084923907871 0.921938872148084 0.48 17.2 17 2 respiratory distress 0.000127579558286389 0.00179882331778854 0.921494778279034 0.479768786127168 17.2 17 2 retinal degeneration 0.00382757844379203 0.0306637725569491 0.920338283828383 0.479166666666667 17.2 17 2 abnormal kidney physiology 0.0345593160119575 0.163278819714614 0.920338283828383 0.479166666666667 17.2 17 2 cleft secondary palate 0.00429180072796928 0.0335521823622716 0.919486907062584 0.478723404255319 17.2 17 2 abnormal inner ear morphology 0.0391017764173632 0.176675914007374 0.918598513915664 0.478260869565217 17.2 17 2 abnormal sleep pattern 0.0391017764173632 0.176675914007374 0.918598513915664 0.478260869565217 17.2 17 2 atrial septal defect 0.0391017764173632 0.176675914007374 0.918598513915664 0.478260869565217 17.2 17 2 abnormal blood vessel physiology 0.125325153585209 0.35853515761151 0.918598513915664 0.478260869565217 17.2 17 2 abnormal cardiovascular development 0.125325153585209 0.35853515761151 0.918598513915664 0.478260869565217 17.2 17 2 abnormal chondrocyte physiology 0.125325153585209 0.35853515761151 0.918598513915664 0.478260869565217 17.2 17 2 abnormal basicranium morphology 0.125325153585209 0.35853515761151 0.918598513915664 0.478260869565217 17.2 17 2 increased or absent threshold for auditory brainstem response 1.3409570910537e-06 3.22283165603486e-05 0.917153722292644 0.477508650519031 17.2 17 2 female infertility 3.48122377547564e-06 7.62955430968779e-05 0.91702879670118 0.477443609022556 17.2 17 2 cochlear hair cell degeneration 0.0442732528318139 0.19152739102223 0.916700583101788 0.477272727272727 17.2 17 2 abnormal salivary gland morphology 0.144347291278032 0.403216043856378 0.914621896972306 0.476190476190476 17.2 17 2 decreased cochlear outer hair cell number 0.144347291278032 0.403216043856378 0.914621896972306 0.476190476190476 17.2 17 2 abnormal bile salt homeostasis 0.144347291278032 0.403216043856378 0.914621896972306 0.476190476190476 17.2 17 2 complete atrioventricular septal defect 0.144347291278032 0.403216043856378 0.914621896972306 0.476190476190476 17.2 17 2 decreased circulating phosphate level 0.0568961155628598 0.220126304947903 0.912335342229875 0.475 17.2 17 2 abnormal female reproductive system morphology 0.0568961155628598 0.220126304947903 0.912335342229875 0.475 17.2 17 2 abnormal thoracic vertebrae morphology 0.0243219243628854 0.118508504665916 0.91152148376223 0.474576271186441 17.2 17 2 hyperactivity 9.1151102499244e-08 2.81662568281825e-06 0.911170493587505 0.474393530997305 17.2 17 2 abnormal rib morphology 0.00104582135278728 0.0107710426224506 0.91055691076354 0.474074074074074 17.2 17 2 impaired branching involved in ureteric bud morphogenesis 0.0645867759162259 0.245656888519284 0.909808097514557 0.473684210526316 17.2 17 2 abnormal triglyceride level 0.166782502396216 0.449841143215366 0.909808097514557 0.473684210526316 17.2 17 2 increased malignant tumor incidence 0.166782502396216 0.449841143215366 0.909808097514557 0.473684210526316 17.2 17 2 abnormal neural crest cell migration 0.166782502396216 0.449841143215366 0.909808097514557 0.473684210526316 17.2 17 2 abnormal metatarsal bone morphology 0.166782502396216 0.449841143215366 0.909808097514557 0.473684210526316 17.2 17 2 abnormal optic vesicle formation 0.166782502396216 0.449841143215366 0.909808097514557 0.473684210526316 17.2 17 2 osteoarthritis 0.166782502396216 0.449841143215366 0.909808097514557 0.473684210526316 17.2 17 2 increased left ventricle weight 0.166782502396216 0.449841143215366 0.909808097514557 0.473684210526316 17.2 17 2 decreased liver glycogen level 0.166782502396216 0.449841143215366 0.909808097514557 0.473684210526316 17.2 17 2 thin interventricular septum 0.166782502396216 0.449841143215366 0.909808097514557 0.473684210526316 17.2 17 2 right-sided stomach 0.166782502396216 0.449841143215366 0.909808097514557 0.473684210526316 17.2 17 2 increased thermal nociceptive threshold 0.00689062451939999 0.046895837187435 0.907586343918673 0.472527472527473 17.2 17 2 abnormal uterus morphology 0.0733920713795169 0.275151134222379 0.90700004783087 0.472222222222222 17.2 17 2 abnormal retinal blood vessel morphology 0.0733920713795169 0.275151134222379 0.90700004783087 0.472222222222222 17.2 17 2 hydroureter 0.193436519279997 0.505168862686606 0.903861639360867 0.470588235294118 17.2 17 2 abnormal involuntary movement 0.193436519279997 0.505168862686606 0.903861639360867 0.470588235294118 17.2 17 2 abnormal testis development 0.193436519279997 0.505168862686606 0.903861639360867 0.470588235294118 17.2 17 2 common atrium 0.193436519279997 0.505168862686606 0.903861639360867 0.470588235294118 17.2 17 2 abnormal survival 0.193436519279997 0.505168862686606 0.903861639360867 0.470588235294118 17.2 17 2 abnormal ductus venosus valve morphology 0.193436519279997 0.505168862686606 0.903861639360867 0.470588235294118 17.2 17 2 polydipsia 0.0951005656647758 0.332929461462586 0.900330929832114 0.46875 17.2 17 2 abnormal auditory brainstem response waveform shape 0.0951005656647758 0.332929461462586 0.900330929832114 0.46875 17.2 17 2 abnormal renal glomerulus morphology 0.00445397517581252 0.034546613080735 0.898678946474624 0.467889908256881 17.2 17 2 abnormal kidney development 0.0310086679491713 0.147908075788233 0.89632945903286 0.466666666666667 17.2 17 2 epidermal hyperplasia 0.0310086679491713 0.147908075788233 0.89632945903286 0.466666666666667 17.2 17 2 abnormal long bone epiphyseal plate morphology 0.0310086679491713 0.147908075788233 0.89632945903286 0.466666666666667 17.2 17 2 enhanced paired-pulse facilitation 0.108474096295788 0.345084923907871 0.89632945903286 0.466666666666667 17.2 17 2 abnormal fontanelle morphology 0.225393149152118 0.554565240866363 0.89632945903286 0.466666666666667 17.2 17 2 no suckling reflex 0.225393149152118 0.554565240866363 0.89632945903286 0.466666666666667 17.2 17 2 audiogenic seizures 0.225393149152118 0.554565240866363 0.89632945903286 0.466666666666667 17.2 17 2 increased airway responsiveness 0.225393149152118 0.554565240866363 0.89632945903286 0.466666666666667 17.2 17 2 abnormal ear development 0.225393149152118 0.554565240866363 0.89632945903286 0.466666666666667 17.2 17 2 absent chorion 0.225393149152118 0.554565240866363 0.89632945903286 0.466666666666667 17.2 17 2 abnormal aorta wall morphology 0.225393149152118 0.554565240866363 0.89632945903286 0.466666666666667 17.2 17 2 ostium primum atrial septal defect 0.225393149152118 0.554565240866363 0.89632945903286 0.466666666666667 17.2 17 2 bicuspid aortic valve 0.225393149152118 0.554565240866363 0.89632945903286 0.466666666666667 17.2 17 2 abnormal coronary vessel morphology 0.225393149152118 0.554565240866363 0.89632945903286 0.466666666666667 17.2 17 2 decreased trabecular bone mass 0.225393149152118 0.554565240866363 0.89632945903286 0.466666666666667 17.2 17 2 increased circulating corticosterone level 0.0569009905855284 0.220126304947903 0.89632945903286 0.466666666666667 17.2 17 2 abnormal blood circulation 0.0643992203771903 0.245130926837431 0.893351620298531 0.465116279069767 17.2 17 2 abnormal stria vascularis morphology 0.123921419751295 0.355534219021847 0.891756349547998 0.464285714285714 17.2 17 2 reddish skin 0.123921419751295 0.355534219021847 0.891756349547998 0.464285714285714 17.2 17 2 enhanced coordination 0.123921419751295 0.355534219021847 0.891756349547998 0.464285714285714 17.2 17 2 abnormal mandible morphology 0.0443382088601194 0.19152739102223 0.88921573316752 0.462962962962963 17.2 17 2 rib fusion 0.0274736536936236 0.132443243338932 0.888684858102942 0.462686567164179 17.2 17 2 abnormal motor capabilities/coordination/movement 0.00287505757723325 0.0242020498252714 0.887598977289033 0.462121212121212 17.2 17 2 abnormal locomotor activation 0.0122204503145903 0.0741423662379108 0.886479684757773 0.461538461538462 17.2 17 2 abnormal skin condition 0.0499911538084776 0.199151518008184 0.886479684757773 0.461538461538462 17.2 17 2 increased susceptibility to injury 0.0499911538084776 0.199151518008184 0.886479684757773 0.461538461538462 17.2 17 2 small lens 0.0826767423234603 0.30221660033741 0.886479684757773 0.461538461538462 17.2 17 2 abnormal lens fiber morphology 0.0826767423234603 0.30221660033741 0.886479684757773 0.461538461538462 17.2 17 2 abnormal ureter morphology 0.141817847657163 0.399515171061372 0.886479684757773 0.461538461538462 17.2 17 2 abnormal mast cell morphology 0.264160054669448 0.601679722425646 0.886479684757773 0.461538461538462 17.2 17 2 abnormal renal/urinary system morphology 0.264160054669448 0.601679722425646 0.886479684757773 0.461538461538462 17.2 17 2 pup cannibalization 0.264160054669448 0.601679722425646 0.886479684757773 0.461538461538462 17.2 17 2 abnormal soleus morphology 0.264160054669448 0.601679722425646 0.886479684757773 0.461538461538462 17.2 17 2 tracheoesophageal fistula 0.264160054669448 0.601679722425646 0.886479684757773 0.461538461538462 17.2 17 2 muscle fatigue 0.264160054669448 0.601679722425646 0.886479684757773 0.461538461538462 17.2 17 2 small interparietal bone 0.264160054669448 0.601679722425646 0.886479684757773 0.461538461538462 17.2 17 2 increased cochlear inner hair cell number 0.264160054669448 0.601679722425646 0.886479684757773 0.461538461538462 17.2 17 2 decreased endocochlear potential 0.264160054669448 0.601679722425646 0.886479684757773 0.461538461538462 17.2 17 2 small pituitary gland 0.264160054669448 0.601679722425646 0.886479684757773 0.461538461538462 17.2 17 2 decreased cardiac stroke volume 0.264160054669448 0.601679722425646 0.886479684757773 0.461538461538462 17.2 17 2 increased startle reflex 0.0136756441548738 0.0804982576332126 0.884819610441748 0.460674157303371 17.2 17 2 decreased heart rate 0.00971979906288622 0.0619383338646783 0.883524752475248 0.46 17.2 17 2 increased body length 0.0563898084523407 0.218829404875503 0.883524752475248 0.46 17.2 17 2 abnormal pancreatic beta cell physiology 0.093795370490577 0.33188617936744 0.88248653302463 0.459459459459459 17.2 17 2 abnormal digit morphology 0.0272488921835851 0.131487137355321 0.880323575835844 0.458333333333333 17.2 17 2 abnormal sensory capabilities/reflexes/nociception 0.16262377595069 0.442105620412396 0.880323575835844 0.458333333333333 17.2 17 2 abnormal cardiac muscle contractility 0.16262377595069 0.442105620412396 0.880323575835844 0.458333333333333 17.2 17 2 abnormal osteoblast morphology 0.16262377595069 0.442105620412396 0.880323575835844 0.458333333333333 17.2 17 2 hypopigmentation 0.16262377595069 0.442105620412396 0.880323575835844 0.458333333333333 17.2 17 2 increased exploration in new environment 0.0214645341733254 0.112406376328731 0.877359523391953 0.45679012345679 17.2 17 2 increased liver weight 0.0189477410221558 0.10555992338771 0.873048174382656 0.454545454545455 17.2 17 2 small kidney 0.0189477410221558 0.10555992338771 0.873048174382656 0.454545454545455 17.2 17 2 short femur 0.0189477410221558 0.10555992338771 0.873048174382656 0.454545454545455 17.2 17 2 decreased systemic arterial blood pressure 0.121070707360112 0.349377476285707 0.873048174382656 0.454545454545455 17.2 17 2 diarrhea 0.121070707360112 0.349377476285707 0.873048174382656 0.454545454545455 17.2 17 2 abnormal oogenesis 0.186910256552664 0.491103345245972 0.873048174382656 0.454545454545455 17.2 17 2 abnormal tracheal cartilage morphology 0.186910256552664 0.491103345245972 0.873048174382656 0.454545454545455 17.2 17 2 abnormal channel response 0.186910256552664 0.491103345245972 0.873048174382656 0.454545454545455 17.2 17 2 abnormal ear position 0.311927772731335 0.601679722425646 0.873048174382656 0.454545454545455 17.2 17 2 premature suture closure 0.311927772731335 0.601679722425646 0.873048174382656 0.454545454545455 17.2 17 2 abnormal awl hair morphology 0.311927772731335 0.601679722425646 0.873048174382656 0.454545454545455 17.2 17 2 abnormal stomach epithelium morphology 0.311927772731335 0.601679722425646 0.873048174382656 0.454545454545455 17.2 17 2 secondary sex reversal 0.311927772731335 0.601679722425646 0.873048174382656 0.454545454545455 17.2 17 2 abnormal bronchiole morphology 0.311927772731335 0.601679722425646 0.873048174382656 0.454545454545455 17.2 17 2 patent ductus arteriosus 0.311927772731335 0.601679722425646 0.873048174382656 0.454545454545455 17.2 17 2 rectal hemorrhage 0.311927772731335 0.601679722425646 0.873048174382656 0.454545454545455 17.2 17 2 abnormal nerve fiber response 0.311927772731335 0.601679722425646 0.873048174382656 0.454545454545455 17.2 17 2 abnormal ureter development 0.311927772731335 0.601679722425646 0.873048174382656 0.454545454545455 17.2 17 2 pathological neovascularization 0.311927772731335 0.601679722425646 0.873048174382656 0.454545454545455 17.2 17 2 abnormal hair medulla 0.311927772731335 0.601679722425646 0.873048174382656 0.454545454545455 17.2 17 2 increased circulating triiodothyronine level 0.311927772731335 0.601679722425646 0.873048174382656 0.454545454545455 17.2 17 2 abnormal platelet aggregation 0.311927772731335 0.601679722425646 0.873048174382656 0.454545454545455 17.2 17 2 abnormal aorta smooth muscle morphology 0.311927772731335 0.601679722425646 0.873048174382656 0.454545454545455 17.2 17 2 abnormal palatal shelf elevation 0.311927772731335 0.601679722425646 0.873048174382656 0.454545454545455 17.2 17 2 decreased core body temperature 0.311927772731335 0.601679722425646 0.873048174382656 0.454545454545455 17.2 17 2 abnormal brain ependyma motile cilium morphology 0.311927772731335 0.601679722425646 0.873048174382656 0.454545454545455 17.2 17 2 decreased embryonic cilium length 0.311927772731335 0.601679722425646 0.873048174382656 0.454545454545455 17.2 17 2 abnormal spatial learning 0.00201338531097282 0.0183454064507139 0.871976949628812 0.45398773006135 17.2 17 2 increased circulating creatinine level 0.021179501006438 0.111030576930484 0.871017829791068 0.453488372093023 17.2 17 2 enlarged kidney 0.0624805583796534 0.23837482970765 0.869753652969891 0.452830188679245 17.2 17 2 hydronephrosis 0.0236746280756441 0.115894873420752 0.868890802123691 0.452380952380952 17.2 17 2 arrest of spermatogenesis 0.0236746280756441 0.115894873420752 0.868890802123691 0.452380952380952 17.2 17 2 decreased cardiac muscle contractility 0.0132276525493874 0.0800578727897838 0.868011357991986 0.451923076923077 17.2 17 2 absent mature ovarian follicles 0.137778030867373 0.388693300986856 0.867415605515671 0.451612903225806 17.2 17 2 abnormal nose morphology 0.137778030867373 0.388693300986856 0.867415605515671 0.451612903225806 17.2 17 2 abnormal cervical vertebrae morphology 0.0703437050331467 0.264920463694099 0.866200737720831 0.450980392156863 17.2 17 2 perinatal lethality 0.103769982400315 0.345084923907871 0.864317692638829 0.45 17.2 17 2 increased susceptibility to weight loss 0.103769982400315 0.345084923907871 0.864317692638829 0.45 17.2 17 2 waved hair 0.215394887925375 0.552081178479517 0.864317692638829 0.45 17.2 17 2 abnormal dopamine level 0.215394887925375 0.552081178479517 0.864317692638829 0.45 17.2 17 2 abnormal male reproductive system physiology 0.215394887925375 0.552081178479517 0.864317692638829 0.45 17.2 17 2 enhanced behavioral response to xenobiotic 0.215394887925375 0.552081178479517 0.864317692638829 0.45 17.2 17 2 abnormal circulating cytokine level 0.215394887925375 0.552081178479517 0.864317692638829 0.45 17.2 17 2 nuclear cataracts 0.215394887925375 0.552081178479517 0.864317692638829 0.45 17.2 17 2 abnormal food intake 0.0423035270468384 0.183968572603165 0.862925876708654 0.449275362318841 17.2 17 2 abnormal cornea morphology 0.033069263199435 0.156685318492561 0.861855249070058 0.448717948717949 17.2 17 2 abnormal parietal bone morphology 0.156985469312733 0.4341723629534 0.861006130598067 0.448275862068966 17.2 17 2 short sternum 0.156985469312733 0.4341723629534 0.861006130598067 0.448275862068966 17.2 17 2 abnormal femur morphology 0.0473800336934863 0.199151518008184 0.86001760461575 0.447761194029851 17.2 17 2 maternal effect 0.0473800336934863 0.199151518008184 0.86001760461575 0.447761194029851 17.2 17 2 pulmonary hypoplasia 0.0892519593411648 0.318985989743028 0.858187779925079 0.446808510638298 17.2 17 2 abnormal eye development 0.0685564884574094 0.258385250057282 0.857458028411537 0.446428571428571 17.2 17 2 kidney cysts 0.0413234758951277 0.18033709875286 0.8565310467592 0.445945945945946 17.2 17 2 rectal prolapse 0.179115964213172 0.479861024211378 0.853647103840819 0.444444444444444 17.2 17 2 absent spleen 0.248993474201015 0.599005093883002 0.853647103840819 0.444444444444444 17.2 17 2 abnormal retinal rod cell morphology 0.248993474201015 0.599005093883002 0.853647103840819 0.444444444444444 17.2 17 2 abnormal phrenic nerve morphology 0.248993474201015 0.599005093883002 0.853647103840819 0.444444444444444 17.2 17 2 abnormal iron level 0.248993474201015 0.599005093883002 0.853647103840819 0.444444444444444 17.2 17 2 absent ureter 0.248993474201015 0.599005093883002 0.853647103840819 0.444444444444444 17.2 17 2 decreased heart rate variability 0.248993474201015 0.599005093883002 0.853647103840819 0.444444444444444 17.2 17 2 small thoracic cage 0.248993474201015 0.599005093883002 0.853647103840819 0.444444444444444 17.2 17 2 albuminuria 0.100586755528585 0.343222982684987 0.853647103840819 0.444444444444444 17.2 17 2 abnormal brain wave pattern 0.0864853835906431 0.311334864951845 0.8495430312262 0.442307692307692 17.2 17 2 decreased body temperature 0.0864853835906431 0.311334864951845 0.8495430312262 0.442307692307692 17.2 17 2 abnormal oocyte morphology 0.150738130541108 0.419419574631997 0.847370286900813 0.441176470588235 17.2 17 2 lung hemorrhage 0.150738130541108 0.419419574631997 0.847370286900813 0.441176470588235 17.2 17 2 thin skin 0.150738130541108 0.419419574631997 0.847370286900813 0.441176470588235 17.2 17 2 abnormal bone remodeling 0.150738130541108 0.419419574631997 0.847370286900813 0.441176470588235 17.2 17 2 decreased osteoblast cell number 0.150738130541108 0.419419574631997 0.847370286900813 0.441176470588235 17.2 17 2 abnormal vertebrae morphology 0.0211472831959859 0.110978622257416 0.84581547903494 0.440366972477064 17.2 17 2 abnormal inner ear vestibule morphology 0.204677383245799 0.527601026760544 0.845110632802411 0.44 17.2 17 2 mandible hypoplasia 0.204677383245799 0.527601026760544 0.845110632802411 0.44 17.2 17 2 decreased placenta weight 0.204677383245799 0.527601026760544 0.845110632802411 0.44 17.2 17 2 kidney cortex cysts 0.170971614913837 0.458783055122081 0.840308867843306 0.4375 17.2 17 2 abnormal lumbar vertebrae morphology 0.170971614913837 0.458783055122081 0.840308867843306 0.4375 17.2 17 2 absent mandible 0.288896530150134 0.601679722425646 0.840308867843306 0.4375 17.2 17 2 mixed cellular infiltration to dermis 0.288896530150134 0.601679722425646 0.840308867843306 0.4375 17.2 17 2 poor circulation 0.288896530150134 0.601679722425646 0.840308867843306 0.4375 17.2 17 2 abnormal meiosis 0.288896530150134 0.601679722425646 0.840308867843306 0.4375 17.2 17 2 impaired muscle relaxation 0.288896530150134 0.601679722425646 0.840308867843306 0.4375 17.2 17 2 increased cochlear outer hair cell number 0.288896530150134 0.601679722425646 0.840308867843306 0.4375 17.2 17 2 increased thymus weight 0.288896530150134 0.601679722425646 0.840308867843306 0.4375 17.2 17 2 decreased circulating prolactin level 0.288896530150134 0.601679722425646 0.840308867843306 0.4375 17.2 17 2 abnormal Langerhans cell physiology 0.288896530150134 0.601679722425646 0.840308867843306 0.4375 17.2 17 2 embryonic lethality between somite formation and embryo turning, incomplete penetrance 0.288896530150134 0.601679722425646 0.840308867843306 0.4375 17.2 17 2 short limbs 0.0422469755147141 0.183883379865007 0.838929050326322 0.436781609195402 17.2 17 2 atelectasis 0.062379175169637 0.238170680329197 0.838618105533762 0.436619718309859 17.2 17 2 decreased liver weight 0.062379175169637 0.238170680329197 0.838618105533762 0.436619718309859 17.2 17 2 abnormal learning/memory/conditioning 0.0936245846600936 0.331753781113936 0.838126247407349 0.436363636363636 17.2 17 2 acanthosis 0.144303267586801 0.403216043856378 0.837230813382342 0.435897435897436 17.2 17 2 circling 0.0469814093825043 0.199151518008184 0.836072016408802 0.435294117647059 17.2 17 2 fragile skeleton 0.234283412681477 0.567735011247124 0.835089558105149 0.434782608695652 17.2 17 2 abnormal cochlear ganglion morphology 0.234283412681477 0.567735011247124 0.835089558105149 0.434782608695652 17.2 17 2 abnormal lens development 0.234283412681477 0.567735011247124 0.835089558105149 0.434782608695652 17.2 17 2 abnormal heart tube morphology 0.194082401619809 0.505793582010765 0.832305926244798 0.433333333333333 17.2 17 2 abnormal hair cycle 0.194082401619809 0.505793582010765 0.832305926244798 0.433333333333333 17.2 17 2 abnormal lactation 0.194082401619809 0.505793582010765 0.832305926244798 0.433333333333333 17.2 17 2 abnormal pain threshold 0.194082401619809 0.505793582010765 0.832305926244798 0.433333333333333 17.2 17 2 increased insulin secretion 0.162875455201482 0.442548000888789 0.83057556049377 0.432432432432432 17.2 17 2 abnormal suckling behavior 0.050393876621388 0.199151518008184 0.829395765663523 0.431818181818182 17.2 17 2 hypertension 0.137898226380261 0.388693300986856 0.829395765663523 0.431818181818182 17.2 17 2 omphalocele 0.137898226380261 0.388693300986856 0.829395765663523 0.431818181818182 17.2 17 2 distended abdomen 0.117507258710199 0.345084923907871 0.828539836080795 0.431372549019608 17.2 17 2 enhanced long term potentiation 0.112425656812106 0.345084923907871 0.823159707275075 0.428571428571429 17.2 17 2 abnormal cartilage morphology 0.155010205237499 0.430824453104221 0.823159707275075 0.428571428571429 17.2 17 2 abnormal muscle morphology 0.155010205237499 0.430824453104221 0.823159707275075 0.428571428571429 17.2 17 2 ovary cysts 0.183909793763222 0.491103345245972 0.823159707275075 0.428571428571429 17.2 17 2 abnormal intestinal goblet cell morphology 0.183909793763222 0.491103345245972 0.823159707275075 0.428571428571429 17.2 17 2 abnormal hippocampus pyramidal cell morphology 0.183909793763222 0.491103345245972 0.823159707275075 0.428571428571429 17.2 17 2 rib bifurcation 0.22051187255958 0.553063501329733 0.823159707275075 0.428571428571429 17.2 17 2 abnormal respiration 0.22051187255958 0.553063501329733 0.823159707275075 0.428571428571429 17.2 17 2 abnormal retinal inner nuclear layer morphology 0.22051187255958 0.553063501329733 0.823159707275075 0.428571428571429 17.2 17 2 abnormal vasoconstriction 0.33668625689241 0.601679722425646 0.823159707275075 0.428571428571429 17.2 17 2 irregularly shaped pupil 0.33668625689241 0.601679722425646 0.823159707275075 0.428571428571429 17.2 17 2 increased aggression towards males 0.33668625689241 0.601679722425646 0.823159707275075 0.428571428571429 17.2 17 2 abnormal anxiety-related response 0.268680585410883 0.601679722425646 0.823159707275075 0.428571428571429 17.2 17 2 extended life span 0.33668625689241 0.601679722425646 0.823159707275075 0.428571428571429 17.2 17 2 abnormal fluid regulation 0.33668625689241 0.601679722425646 0.823159707275075 0.428571428571429 17.2 17 2 absent otoliths 0.33668625689241 0.601679722425646 0.823159707275075 0.428571428571429 17.2 17 2 hypoalgesia 0.268680585410883 0.601679722425646 0.823159707275075 0.428571428571429 17.2 17 2 left pulmonary isomerism 0.268680585410883 0.601679722425646 0.823159707275075 0.428571428571429 17.2 17 2 abnormal hair cuticle 0.33668625689241 0.601679722425646 0.823159707275075 0.428571428571429 17.2 17 2 enlarged stomach 0.33668625689241 0.601679722425646 0.823159707275075 0.428571428571429 17.2 17 2 abnormal stapes morphology 0.268680585410883 0.601679722425646 0.823159707275075 0.428571428571429 17.2 17 2 premature hair loss 0.33668625689241 0.601679722425646 0.823159707275075 0.428571428571429 17.2 17 2 abnormal viscerocranium morphology 0.33668625689241 0.601679722425646 0.823159707275075 0.428571428571429 17.2 17 2 increased lung compliance 0.33668625689241 0.601679722425646 0.823159707275075 0.428571428571429 17.2 17 2 abnormal respiratory motile cilium physiology 0.33668625689241 0.601679722425646 0.823159707275075 0.428571428571429 17.2 17 2 abnormal renal tubule epithelial cell primary cilium morphology 0.33668625689241 0.601679722425646 0.823159707275075 0.428571428571429 17.2 17 2 abnormal hair follicle morphology 0.0964438127501967 0.332929461462586 0.823159707275075 0.428571428571429 17.2 17 2 organ of Corti degeneration 0.131638461027311 0.375732268279331 0.823159707275075 0.428571428571429 17.2 17 2 abnormal long bone epiphyseal plate proliferative zone 0.125585109798009 0.359072368531662 0.818078474514118 0.425925925925926 17.2 17 2 increased systemic arterial blood pressure 0.147459196492615 0.411446720443501 0.817321695166741 0.425531914893617 17.2 17 2 belly spot 0.207740704690265 0.53438986858018 0.814844962757145 0.424242424242424 17.2 17 2 dextrocardia 0.207740704690265 0.53438986858018 0.814844962757145 0.424242424242424 17.2 17 2 abnormal middle ear ossicle morphology 0.207740704690265 0.53438986858018 0.814844962757145 0.424242424242424 17.2 17 2 abnormal colon morphology 0.119768965098085 0.346223475515962 0.813858467644848 0.423728813559322 17.2 17 2 abnormal stomach morphology 0.250774376010799 0.601679722425646 0.812606377694626 0.423076923076923 17.2 17 2 abnormal kidney cortex morphology 0.250774376010799 0.601679722425646 0.812606377694626 0.423076923076923 17.2 17 2 thick skin 0.250774376010799 0.601679722425646 0.812606377694626 0.423076923076923 17.2 17 2 no spontaneous movement 0.250774376010799 0.601679722425646 0.812606377694626 0.423076923076923 17.2 17 2 decreased anxiety-related response 0.0384711766162723 0.176675914007374 0.812005781702242 0.422764227642276 17.2 17 2 irregular heartbeat 0.16516430123341 0.448522051657322 0.810964748648778 0.422222222222222 17.2 17 2 abnormal axial skeleton morphology 0.0937465576902637 0.33188617936744 0.808718308901828 0.421052631578947 17.2 17 2 abnormal retinal outer nuclear layer morphology 0.195919114808929 0.506784496664955 0.808718308901828 0.421052631578947 17.2 17 2 hyporesponsive to tactile stimuli 0.195919114808929 0.506784496664955 0.808718308901828 0.421052631578947 17.2 17 2 irregular coat pigmentation 0.308783271877232 0.601679722425646 0.808718308901828 0.421052631578947 17.2 17 2 flaky skin 0.308783271877232 0.601679722425646 0.808718308901828 0.421052631578947 17.2 17 2 shiny skin 0.308783271877232 0.601679722425646 0.808718308901828 0.421052631578947 17.2 17 2 thin dermal layer 0.308783271877232 0.601679722425646 0.808718308901828 0.421052631578947 17.2 17 2 unresponsive to tactile stimuli 0.308783271877232 0.601679722425646 0.808718308901828 0.421052631578947 17.2 17 2 abnormal neurotransmitter level 0.308783271877232 0.601679722425646 0.808718308901828 0.421052631578947 17.2 17 2 decreased germ cell number 0.308783271877232 0.601679722425646 0.808718308901828 0.421052631578947 17.2 17 2 abnormal nasal septum morphology 0.308783271877232 0.601679722425646 0.808718308901828 0.421052631578947 17.2 17 2 maternal imprinting 0.308783271877232 0.601679722425646 0.808718308901828 0.421052631578947 17.2 17 2 abnormal sternum morphology 0.108891117803524 0.345084923907871 0.807253239501644 0.420289855072464 17.2 17 2 abnormal hindlimb morphology 0.15660403200799 0.4341723629534 0.806696513129574 0.42 17.2 17 2 abnormal organ of Corti morphology 0.184967883926181 0.491103345245972 0.804016458268678 0.418604651162791 17.2 17 2 abnormal intestinal mucosa morphology 0.184967883926181 0.491103345245972 0.804016458268678 0.418604651162791 17.2 17 2 abnormal axon guidance 0.184967883926181 0.491103345245972 0.804016458268678 0.418604651162791 17.2 17 2 cochlear outer hair cell degeneration 0.114943314788753 0.345084923907871 0.800294159850768 0.416666666666667 17.2 17 2 abnormal epidermis stratum granulosum morphology 0.220271799210304 0.553063501329733 0.800294159850768 0.416666666666667 17.2 17 2 short radius 0.220271799210304 0.553063501329733 0.800294159850768 0.416666666666667 17.2 17 2 abnormal urine homeostasis 0.0780230444074254 0.286679945293162 0.800294159850768 0.416666666666667 17.2 17 2 abnormal intestinal epithelium morphology 0.174805471424377 0.468565312681183 0.800294159850768 0.416666666666667 17.2 17 2 abnormal cardiovascular system morphology 0.174805471424377 0.468565312681183 0.800294159850768 0.416666666666667 17.2 17 2 abnormal malleus morphology 0.28546886748918 0.601679722425646 0.800294159850768 0.416666666666667 17.2 17 2 abnormal adrenal gland morphology 0.28546886748918 0.601679722425646 0.800294159850768 0.416666666666667 17.2 17 2 small lymph nodes 0.28546886748918 0.601679722425646 0.800294159850768 0.416666666666667 17.2 17 2 abnormal retinal ganglion layer morphology 0.28546886748918 0.601679722425646 0.800294159850768 0.416666666666667 17.2 17 2 abnormal lung saccule morphology 0.28546886748918 0.601679722425646 0.800294159850768 0.416666666666667 17.2 17 2 decreased digestive secretion 0.394521734578431 0.678948214783077 0.800294159850768 0.416666666666667 17.2 17 2 abnormal glossopharyngeal nerve morphology 0.394521734578431 0.678948214783077 0.800294159850768 0.416666666666667 17.2 17 2 abnormal mating frequency 0.394521734578431 0.678948214783077 0.800294159850768 0.416666666666667 17.2 17 2 impaired embryo implantation 0.394521734578431 0.678948214783077 0.800294159850768 0.416666666666667 17.2 17 2 increased litter size 0.394521734578431 0.678948214783077 0.800294159850768 0.416666666666667 17.2 17 2 small thyroid gland 0.394521734578431 0.678948214783077 0.800294159850768 0.416666666666667 17.2 17 2 abnormal aorta elastic fiber morphology 0.394521734578431 0.678948214783077 0.800294159850768 0.416666666666667 17.2 17 2 abnormal alisphenoid bone morphology 0.394521734578431 0.678948214783077 0.800294159850768 0.416666666666667 17.2 17 2 decreased left ventricle systolic pressure 0.394521734578431 0.678948214783077 0.800294159850768 0.416666666666667 17.2 17 2 vestibular saccular macula degeneration 0.394521734578431 0.678948214783077 0.800294159850768 0.416666666666667 17.2 17 2 bowed ulna 0.394521734578431 0.678948214783077 0.800294159850768 0.416666666666667 17.2 17 2 small parietal bone 0.394521734578431 0.678948214783077 0.800294159850768 0.416666666666667 17.2 17 2 abnormal cochlear outer hair cell physiology 0.394521734578431 0.678948214783077 0.800294159850768 0.416666666666667 17.2 17 2 abnormal behavioral response to addictive substance 0.394521734578431 0.678948214783077 0.800294159850768 0.416666666666667 17.2 17 2 abnormal aorta elastic tissue morphology 0.394521734578431 0.678948214783077 0.800294159850768 0.416666666666667 17.2 17 2 abnormal respiratory motile cilium morphology 0.394521734578431 0.678948214783077 0.800294159850768 0.416666666666667 17.2 17 2 abnormal colon goblet cell morphology 0.394521734578431 0.678948214783077 0.800294159850768 0.416666666666667 17.2 17 2 polyuria 0.109428749509265 0.345084923907871 0.798215473721285 0.415584415584416 17.2 17 2 abnormal cholesterol homeostasis 0.207103857947013 0.533579333654267 0.796390285900276 0.414634146341463 17.2 17 2 thick epidermis 0.127182937038161 0.363223370703129 0.795721050365906 0.414285714285714 17.2 17 2 deafness 0.0819864543631393 0.300134371196923 0.795443892215308 0.414141414141414 17.2 17 2 abnormal CNS synaptic transmission 0.0819864543631393 0.300134371196923 0.795443892215308 0.414141414141414 17.2 17 2 abnormal middle ear morphology 0.265354039557353 0.601679722425646 0.794774889782831 0.413793103448276 17.2 17 2 aphagia 0.265354039557353 0.601679722425646 0.794774889782831 0.413793103448276 17.2 17 2 abnormal limb morphology 0.120878453875371 0.349227821155617 0.793891806571961 0.413333333333333 17.2 17 2 abnormal vision 0.247642506594676 0.597778491173465 0.790878934440759 0.411764705882353 17.2 17 2 increased width of hypertrophic chondrocyte zone 0.247642506594676 0.597778491173465 0.790878934440759 0.411764705882353 17.2 17 2 increased susceptibility to weight gain 0.247642506594676 0.597778491173465 0.790878934440759 0.411764705882353 17.2 17 2 distended urinary bladder 0.355718537759231 0.623572841914086 0.790878934440759 0.411764705882353 17.2 17 2 aminoaciduria 0.355718537759231 0.623572841914086 0.790878934440759 0.411764705882353 17.2 17 2 abnormal tarsal bone morphology 0.355718537759231 0.623572841914086 0.790878934440759 0.411764705882353 17.2 17 2 delayed heart development 0.355718537759231 0.623572841914086 0.790878934440759 0.411764705882353 17.2 17 2 cochlear inner hair cell degeneration 0.183971773316444 0.491103345245972 0.790878934440759 0.411764705882353 17.2 17 2 increased rib number 0.126695979240424 0.362040492085645 0.78798194200691 0.41025641025641 17.2 17 2 abnormal heart looping 0.231825791137366 0.563042760350708 0.78798194200691 0.41025641025641 17.2 17 2 increased anxiety-related response 0.0566717854024434 0.219752246591704 0.787627633579748 0.410071942446043 17.2 17 2 abnormal gametogenesis 0.217554569919509 0.553063501329733 0.78574335694439 0.409090909090909 17.2 17 2 abnormal basisphenoid bone morphology 0.325290813081958 0.601679722425646 0.78574335694439 0.409090909090909 17.2 17 2 parakeratosis 0.325290813081958 0.601679722425646 0.78574335694439 0.409090909090909 17.2 17 2 abnormal retinal layer morphology 0.325290813081958 0.601679722425646 0.78574335694439 0.409090909090909 17.2 17 2 abnormal basement membrane morphology 0.325290813081958 0.601679722425646 0.78574335694439 0.409090909090909 17.2 17 2 abnormal vertebral body morphology 0.278382232971302 0.601679722425646 0.780286805854499 0.40625 17.2 17 2 increased circulating follicle stimulating hormone level 0.278382232971302 0.601679722425646 0.780286805854499 0.40625 17.2 17 2 abnormal lymphatic vessel morphology 0.278382232971302 0.601679722425646 0.780286805854499 0.40625 17.2 17 2 abnormal depression-related behavior 0.278382232971302 0.601679722425646 0.780286805854499 0.40625 17.2 17 2 abnormal epidermal layer morphology 0.162336318475711 0.442105620412396 0.779416920898139 0.405797101449275 17.2 17 2 abnormal coat appearance 0.162336318475711 0.442105620412396 0.779416920898139 0.405797101449275 17.2 17 2 impaired skeletal muscle contractility 0.25940567012541 0.601679722425646 0.778664587962909 0.405405405405405 17.2 17 2 decreased food intake 0.145545301872831 0.406334386541713 0.778007487044797 0.40506329113924 17.2 17 2 abnormal eye electrophysiology 0.08850605497898 0.316547536678954 0.777806555359093 0.40495867768595 17.2 17 2 abnormal optic nerve morphology 0.242527541789483 0.586284995336578 0.77742861242646 0.404761904761905 17.2 17 2 abnormal vibrissa morphology 0.242527541789483 0.586284995336578 0.77742861242646 0.404761904761905 17.2 17 2 increased percent body fat/body weight 0.213585254925798 0.549140384111548 0.775669724163052 0.403846153846154 17.2 17 2 dehydration 0.185771906100744 0.491103345245972 0.768282393456737 0.4 17.2 17 2 abnormal action potential 0.185771906100744 0.491103345245972 0.768282393456737 0.4 17.2 17 2 abnormal axon extension 0.236557017698595 0.57296551268282 0.768282393456737 0.4 17.2 17 2 abnormal feces composition 0.339329856984768 0.601679722425646 0.768282393456737 0.4 17.2 17 2 abnormal cochlear outer hair cell morphology 0.339329856984768 0.601679722425646 0.768282393456737 0.4 17.2 17 2 decreased paired-pulse facilitation 0.371042194511802 0.644962066089388 0.768282393456737 0.4 17.2 17 2 abnormal hyoid bone morphology 0.371042194511802 0.644962066089388 0.768282393456737 0.4 17.2 17 2 decreased chondrocyte number 0.410881662052604 0.693739820374911 0.768282393456737 0.4 17.2 17 2 decreased salivation 0.410881662052604 0.693739820374911 0.768282393456737 0.4 17.2 17 2 vagina atresia 0.410881662052604 0.693739820374911 0.768282393456737 0.4 17.2 17 2 hyperpigmentation 0.410881662052604 0.693739820374911 0.768282393456737 0.4 17.2 17 2 abnormal respiratory system morphology 0.410881662052604 0.693739820374911 0.768282393456737 0.4 17.2 17 2 increased alcohol consumption 0.410881662052604 0.693739820374911 0.768282393456737 0.4 17.2 17 2 abnormal pericyte morphology 0.410881662052604 0.693739820374911 0.768282393456737 0.4 17.2 17 2 decreased aggression towards males 0.410881662052604 0.693739820374911 0.768282393456737 0.4 17.2 17 2 abnormal secondary palate development 0.410881662052604 0.693739820374911 0.768282393456737 0.4 17.2 17 2 herniated liver 0.410881662052604 0.693739820374911 0.768282393456737 0.4 17.2 17 2 increased susceptibility to pharmacologically induced seizures 0.159189430813188 0.43419266353926 0.760279451858229 0.395833333333333 17.2 17 2 increased grooming behavior 0.30080994533181 0.601679722425646 0.758173414595464 0.394736842105263 17.2 17 2 abnormal reproductive system physiology 0.30080994533181 0.601679722425646 0.758173414595464 0.394736842105263 17.2 17 2 impaired swimming 0.223832519929108 0.553737835229892 0.756641751131635 0.393939393939394 17.2 17 2 absent vibrissae 0.324299226353977 0.601679722425646 0.756641751131635 0.393939393939394 17.2 17 2 head tossing 0.324299226353977 0.601679722425646 0.756641751131635 0.393939393939394 17.2 17 2 abnormal maternal nurturing 0.23796280359912 0.575809799564992 0.755687600121381 0.39344262295082 17.2 17 2 absent corpus callosum 0.351498609250078 0.617045018002519 0.754563065002152 0.392857142857143 17.2 17 2 decreased circulating progesterone level 0.351498609250078 0.617045018002519 0.754563065002152 0.392857142857143 17.2 17 2 increased kidney weight 0.270482981816112 0.601679722425646 0.753218032800722 0.392156862745098 17.2 17 2 abnormal pulmonary artery morphology 0.383795570482267 0.664826937029693 0.751580602294634 0.391304347826087 17.2 17 2 hypotension 0.383795570482267 0.664826937029693 0.751580602294634 0.391304347826087 17.2 17 2 short humerus 0.310583526852471 0.601679722425646 0.749543798494378 0.390243902439024 17.2 17 2 abnormal heart left ventricle morphology 0.237497420329386 0.574963341186712 0.746941215860716 0.388888888888889 17.2 17 2 abnormal cochlea morphology 0.278668078028591 0.601679722425646 0.746941215860716 0.388888888888889 17.2 17 2 polyphagia 0.278668078028591 0.601679722425646 0.746941215860716 0.388888888888889 17.2 17 2 abnormal reflex 0.334586825291772 0.601679722425646 0.746941215860716 0.388888888888889 17.2 17 2 abnormal limb bone morphology 0.334586825291772 0.601679722425646 0.746941215860716 0.388888888888889 17.2 17 2 abnormal heart shape 0.423634487296277 0.693739820374911 0.746941215860716 0.388888888888889 17.2 17 2 delayed kidney development 0.423634487296277 0.693739820374911 0.746941215860716 0.388888888888889 17.2 17 2 decreased activity of thyroid 0.423634487296277 0.693739820374911 0.746941215860716 0.388888888888889 17.2 17 2 abnormal anterior eye segment morphology 0.423634487296277 0.693739820374911 0.746941215860716 0.388888888888889 17.2 17 2 abnormal pregnancy 0.423634487296277 0.693739820374911 0.746941215860716 0.388888888888889 17.2 17 2 abnormal epidermis stratum corneum morphology 0.298001397422672 0.601679722425646 0.744763544677449 0.387755102040816 17.2 17 2 abnormal social investigation 0.229973293400994 0.563042760350708 0.744273568661214 0.3875 17.2 17 2 abnormal cranial ganglia morphology 0.362208546194477 0.634279309157875 0.743499090442003 0.387096774193548 17.2 17 2 abnormal podocyte morphology 0.362208546194477 0.634279309157875 0.743499090442003 0.387096774193548 17.2 17 2 small cranium 0.362208546194477 0.634279309157875 0.743499090442003 0.387096774193548 17.2 17 2 increased vascular permeability 0.343925041703338 0.604176229687184 0.738733070631478 0.384615384615385 17.2 17 2 abnormal xiphoid process morphology 0.394677032593499 0.678948214783077 0.738733070631478 0.384615384615385 17.2 17 2 small seminal vesicle 0.394677032593499 0.678948214783077 0.738733070631478 0.384615384615385 17.2 17 2 abnormal membranous labyrinth morphology 0.475997784521546 0.758031042892026 0.738733070631478 0.384615384615385 17.2 17 2 short premaxilla 0.475997784521546 0.758031042892026 0.738733070631478 0.384615384615385 17.2 17 2 small trigeminal ganglion 0.475997784521546 0.758031042892026 0.738733070631478 0.384615384615385 17.2 17 2 tight skin 0.475997784521546 0.758031042892026 0.738733070631478 0.384615384615385 17.2 17 2 excessive scratching 0.475997784521546 0.758031042892026 0.738733070631478 0.384615384615385 17.2 17 2 abnormal intercostal muscle morphology 0.475997784521546 0.758031042892026 0.738733070631478 0.384615384615385 17.2 17 2 abnormal bile duct development 0.475997784521546 0.758031042892026 0.738733070631478 0.384615384615385 17.2 17 2 abnormal dopaminergic neuron morphology 0.475997784521546 0.758031042892026 0.738733070631478 0.384615384615385 17.2 17 2 abnormal retinal inner plexiform layer morphology 0.475997784521546 0.758031042892026 0.738733070631478 0.384615384615385 17.2 17 2 abnormal vertebral arch development 0.475997784521546 0.758031042892026 0.738733070631478 0.384615384615385 17.2 17 2 abnormal hair follicle inner root sheath morphology 0.475997784521546 0.758031042892026 0.738733070631478 0.384615384615385 17.2 17 2 overexpanded pulmonary alveoli 0.371753386204972 0.644962066089388 0.734387581980704 0.382352941176471 17.2 17 2 abnormal skin physiology 0.371753386204972 0.644962066089388 0.734387581980704 0.382352941176471 17.2 17 2 abnormal contextual conditioning behavior 0.313590605288236 0.601679722425646 0.733360466481431 0.381818181818182 17.2 17 2 small ears 0.434033953958521 0.709602011483287 0.731697517577845 0.380952380952381 17.2 17 2 abnormal associative learning 0.434033953958521 0.709602011483287 0.731697517577845 0.380952380952381 17.2 17 2 dry skin 0.434033953958521 0.709602011483287 0.731697517577845 0.380952380952381 17.2 17 2 increased keratinocyte proliferation 0.434033953958521 0.709602011483287 0.731697517577845 0.380952380952381 17.2 17 2 abnormal spinal nerve morphology 0.404142512951187 0.693739820374911 0.728543648967595 0.379310344827586 17.2 17 2 absent long term depression 0.404142512951187 0.693739820374911 0.728543648967595 0.379310344827586 17.2 17 2 increased retinal apoptosis 0.404142512951187 0.693739820374911 0.728543648967595 0.379310344827586 17.2 17 2 reduced long term potentiation 0.262719262806167 0.601679722425646 0.720264743865691 0.375 17.2 17 2 abnormal crypts of Lieberkuhn morphology 0.412504334128382 0.693739820374911 0.720264743865691 0.375 17.2 17 2 abnormal diaphragm morphology 0.412504334128382 0.693739820374911 0.720264743865691 0.375 17.2 17 2 abnormal hair follicle orientation 0.484072741194086 0.768185610028893 0.720264743865691 0.375 17.2 17 2 abnormal mouth morphology 0.484072741194086 0.768185610028893 0.720264743865691 0.375 17.2 17 2 disorganized retinal layers 0.484072741194086 0.768185610028893 0.720264743865691 0.375 17.2 17 2 white spotting 0.484072741194086 0.768185610028893 0.720264743865691 0.375 17.2 17 2 decreased cochlear coiling 0.484072741194086 0.768185610028893 0.720264743865691 0.375 17.2 17 2 abnormal molar crown morphology 0.484072741194086 0.768185610028893 0.720264743865691 0.375 17.2 17 2 bowed tibia 0.484072741194086 0.768185610028893 0.720264743865691 0.375 17.2 17 2 bowed radius 0.484072741194086 0.768185610028893 0.720264743865691 0.375 17.2 17 2 abnormal intestinal lipid absorption 0.484072741194086 0.768185610028893 0.720264743865691 0.375 17.2 17 2 dilated respiratory conducting tubes 0.484072741194086 0.768185610028893 0.720264743865691 0.375 17.2 17 2 oligodactyly 0.367595643119411 0.643486391456394 0.720264743865691 0.375 17.2 17 2 impaired ovarian folliculogenesis 0.388159336503916 0.672152001081442 0.720264743865691 0.375 17.2 17 2 abnormal digestive system morphology 0.442791592278119 0.722732339758412 0.720264743865691 0.375 17.2 17 2 abnormal foregut morphology 0.442791592278119 0.722732339758412 0.720264743865691 0.375 17.2 17 2 decreased ovulation rate 0.442791592278119 0.722732339758412 0.720264743865691 0.375 17.2 17 2 short tail 0.311638097783154 0.601679722425646 0.717372114372254 0.373493975903614 17.2 17 2 cryptorchism 0.450346149341635 0.72624703175839 0.711372586534016 0.37037037037037 17.2 17 2 abnormal forelimb morphology 0.401898400894711 0.691131885396193 0.709826124389377 0.369565217391304 17.2 17 2 decreased grooming behavior 0.490631029624054 0.776858488981435 0.7076285202891 0.368421052631579 17.2 17 2 abnormal long term depression 0.490631029624054 0.776858488981435 0.7076285202891 0.368421052631579 17.2 17 2 abnormal response to novelty 0.490631029624054 0.776858488981435 0.7076285202891 0.368421052631579 17.2 17 2 abnormal digestive system development 0.490631029624054 0.776858488981435 0.7076285202891 0.368421052631579 17.2 17 2 abnormal cochlear inner hair cell morphology 0.490631029624054 0.776858488981435 0.7076285202891 0.368421052631579 17.2 17 2 eyelids fail to open 0.490631029624054 0.776858488981435 0.7076285202891 0.368421052631579 17.2 17 2 decreased fertilization frequency 0.490631029624054 0.776858488981435 0.7076285202891 0.368421052631579 17.2 17 2 decreased urine osmolality 0.408005205136872 0.693739820374911 0.705565463378636 0.36734693877551 17.2 17 2 short ulna 0.432914611302826 0.70870358382085 0.702697311088479 0.365853658536585 17.2 17 2 renal interstitial fibrosis 0.43858187478525 0.716566445667198 0.698438539506125 0.363636363636364 17.2 17 2 abnormal photoreceptor outer segment morphology 0.43858187478525 0.716566445667198 0.698438539506125 0.363636363636364 17.2 17 2 abnormal tooth development 0.462907252856612 0.744079941189461 0.698438539506125 0.363636363636364 17.2 17 2 abnormal aorta morphology 0.462907252856612 0.744079941189461 0.698438539506125 0.363636363636364 17.2 17 2 intestinal ulcer 0.496172891602272 0.784385171821196 0.698438539506125 0.363636363636364 17.2 17 2 decreased airway responsiveness 0.496172891602272 0.784385171821196 0.698438539506125 0.363636363636364 17.2 17 2 abnormal retinal outer plexiform layer morphology 0.496172891602272 0.784385171821196 0.698438539506125 0.363636363636364 17.2 17 2 abnormal blood-brain barrier function 0.496172891602272 0.784385171821196 0.698438539506125 0.363636363636364 17.2 17 2 cleft upper lip 0.496172891602272 0.784385171821196 0.698438539506125 0.363636363636364 17.2 17 2 abnormal vertebrae development 0.500988818380629 0.789140234209794 0.691454154111063 0.36 17.2 17 2 abnormal circulating hormone level 0.473127617284546 0.756122677799749 0.689484199256046 0.358974358974359 17.2 17 2 short mandible 0.457535103762353 0.737362209659122 0.685966422729229 0.357142857142857 17.2 17 2 abnormal jaw morphology 0.505261449392499 0.789140234209794 0.685966422729229 0.357142857142857 17.2 17 2 abnormal kidney blood vessel morphology 0.553393077648844 0.789140234209794 0.685966422729229 0.357142857142857 17.2 17 2 abnormal placing response 0.553393077648844 0.789140234209794 0.685966422729229 0.357142857142857 17.2 17 2 abnormal ovulation 0.505261449392499 0.789140234209794 0.685966422729229 0.357142857142857 17.2 17 2 abnormal olfactory system physiology 0.553393077648844 0.789140234209794 0.685966422729229 0.357142857142857 17.2 17 2 abnormal voluntary movement 0.553393077648844 0.789140234209794 0.685966422729229 0.357142857142857 17.2 17 2 abnormal imprinting 0.553393077648844 0.789140234209794 0.685966422729229 0.357142857142857 17.2 17 2 decreased tongue size 0.553393077648844 0.789140234209794 0.685966422729229 0.357142857142857 17.2 17 2 sternebra fusion 0.553393077648844 0.789140234209794 0.685966422729229 0.357142857142857 17.2 17 2 abnormal cartilage development 0.481759369250398 0.766960915846633 0.682917683072655 0.355555555555556 17.2 17 2 abnormal body temperature homeostasis 0.509112643095875 0.789140234209794 0.68154083290517 0.354838709677419 17.2 17 2 abnormal intestine physiology 0.509112643095875 0.789140234209794 0.68154083290517 0.354838709677419 17.2 17 2 abnormal excitatory postsynaptic potential 0.45582498500905 0.73484423215166 0.67927406738553 0.353658536585366 17.2 17 2 absence seizures 0.554084124885826 0.789140234209794 0.67789622952065 0.352941176470588 17.2 17 2 decreased growth hormone level 0.554084124885826 0.789140234209794 0.67789622952065 0.352941176470588 17.2 17 2 abnormal electroretinogram waveform feature 0.554084124885826 0.789140234209794 0.67789622952065 0.352941176470588 17.2 17 2 abnormal basioccipital bone morphology 0.55502501776142 0.789140234209794 0.672247094274645 0.35 17.2 17 2 abnormal fibula morphology 0.55502501776142 0.789140234209794 0.672247094274645 0.35 17.2 17 2 abnormal heart right ventricle morphology 0.55502501776142 0.789140234209794 0.672247094274645 0.35 17.2 17 2 kidney atrophy 0.55502501776142 0.789140234209794 0.672247094274645 0.35 17.2 17 2 abnormal heart electrocardiography waveform feature 0.55502501776142 0.789140234209794 0.672247094274645 0.35 17.2 17 2 abnormal carpal bone morphology 0.556107462866275 0.789140234209794 0.668071646484119 0.347826086956522 17.2 17 2 abnormal innervation pattern to muscle 0.556107462866275 0.789140234209794 0.668071646484119 0.347826086956522 17.2 17 2 bidirectional circling 0.556107462866275 0.789140234209794 0.668071646484119 0.347826086956522 17.2 17 2 abnormal sacral vertebrae morphology 0.556107462866275 0.789140234209794 0.668071646484119 0.347826086956522 17.2 17 2 abnormal crista ampullaris morphology 0.556107462866275 0.789140234209794 0.668071646484119 0.347826086956522 17.2 17 2 decreased epididymis weight 0.556107462866275 0.789140234209794 0.668071646484119 0.347826086956522 17.2 17 2 abnormal excitatory postsynaptic currents 0.514589012649474 0.789140234209794 0.66485976356833 0.346153846153846 17.2 17 2 decreased retinal photoreceptor cell number 0.558481942256348 0.789140234209794 0.662312408152359 0.344827586206897 17.2 17 2 stomach inflammation 0.558481942256348 0.789140234209794 0.662312408152359 0.344827586206897 17.2 17 2 abnormal serotonin level 0.559716995412181 0.789140234209794 0.660242681876883 0.34375 17.2 17 2 abnormal digestive system physiology 0.567127558908209 0.789140234209794 0.653040034438226 0.34 17.2 17 2 abnormal hair shaft morphology 0.606059473222833 0.842454841934505 0.640235327880614 0.333333333333333 17.2 17 2 reduced long term depression 0.60731771132036 0.84373236912002 0.640235327880614 0.333333333333333 17.2 17 2 abnormal tail morphology 0.607167592072736 0.84373236912002 0.640235327880614 0.333333333333333 17.2 17 2 abnormal epidermis stratum basale morphology 0.608121866689965 0.844613703736063 0.640235327880614 0.333333333333333 17.2 17 2 emphysema 0.609230221931994 0.845916928303564 0.640235327880614 0.333333333333333 17.2 17 2 abnormal nervous system electrophysiology 0.609771732609019 0.846432580839807 0.640235327880614 0.333333333333333 17.2 17 2 decreased susceptibility to pharmacologically induced seizures 0.610734218084024 0.847532143645193 0.640235327880614 0.333333333333333 17.2 17 2 increased vasoconstriction 0.61552054966287 0.853698002389958 0.640235327880614 0.333333333333333 17.2 17 2 decreased vocalization 0.61552054966287 0.853698002389958 0.640235327880614 0.333333333333333 17.2 17 2 abnormal stomach glandular epithelium morphology 0.6193089436806 0.857995542971591 0.640235327880614 0.333333333333333 17.2 17 2 blepharoptosis 0.6193089436806 0.857995542971591 0.640235327880614 0.333333333333333 17.2 17 2 abnormal metanephric mesenchyme morphology 0.6193089436806 0.857995542971591 0.640235327880614 0.333333333333333 17.2 17 2 decreased fluid intake 0.6193089436806 0.857995542971591 0.640235327880614 0.333333333333333 17.2 17 2 abnormal pup retrieval 0.624648785446964 0.863229918777401 0.640235327880614 0.333333333333333 17.2 17 2 abnormal seizure response to electrical stimulation 0.624648785446964 0.863229918777401 0.640235327880614 0.333333333333333 17.2 17 2 abnormal apical ectodermal ridge morphology 0.624648785446964 0.863229918777401 0.640235327880614 0.333333333333333 17.2 17 2 absent egg cylinders 0.624648785446964 0.863229918777401 0.640235327880614 0.333333333333333 17.2 17 2 abnormal bronchus morphology 0.624648785446964 0.863229918777401 0.640235327880614 0.333333333333333 17.2 17 2 altered righting response 0.624648785446964 0.863229918777401 0.640235327880614 0.333333333333333 17.2 17 2 greasy coat 0.624648785446964 0.863229918777401 0.640235327880614 0.333333333333333 17.2 17 2 abnormal rostral migratory stream morphology 0.624648785446964 0.863229918777401 0.640235327880614 0.333333333333333 17.2 17 2 abnormal Muller cell morphology 0.624648785446964 0.863229918777401 0.640235327880614 0.333333333333333 17.2 17 2 abnormal retinal photoreceptor morphology 0.653793064614185 0.894560092534535 0.621404877060596 0.323529411764706 17.2 17 2 abnormal stomach mucosa morphology 0.665366141586105 0.89809428790027 0.61462591476539 0.32 17.2 17 2 abnormal innervation 0.683154296677515 0.91687076339821 0.612991271375056 0.319148936170213 17.2 17 2 failure of palatal shelf elevation 0.671216123424483 0.904224265918441 0.611133722067859 0.318181818181818 17.2 17 2 abnormal eye physiology 0.707387355128565 0.91687076339821 0.608223561486583 0.316666666666667 17.2 17 2 abnormal photoreceptor inner segment morphology 0.678698750168236 0.9138095486027 0.606538731676371 0.315789473684211 17.2 17 2 abnormal sternebra morphology 0.678698750168236 0.9138095486027 0.606538731676371 0.315789473684211 17.2 17 2 abnormal cued conditioning behavior 0.715035162449975 0.91687076339821 0.602574426240578 0.313725490196078 17.2 17 2 increased dopamine level 0.701081743137013 0.91687076339821 0.600220619888076 0.3125 17.2 17 2 paternal imprinting 0.68854698738009 0.91687076339821 0.600220619888076 0.3125 17.2 17 2 abnormal pulmonary elastic fiber morphology 0.68854698738009 0.91687076339821 0.600220619888076 0.3125 17.2 17 2 decreased aggression towards mice 0.68854698738009 0.91687076339821 0.600220619888076 0.3125 17.2 17 2 abnormal epididymis epithelium morphology 0.68854698738009 0.91687076339821 0.600220619888076 0.3125 17.2 17 2 impaired behavioral response to addictive substance 0.68854698738009 0.91687076339821 0.600220619888076 0.3125 17.2 17 2 decreased skeletal muscle weight 0.68854698738009 0.91687076339821 0.600220619888076 0.3125 17.2 17 2 decreased midbrain size 0.68854698738009 0.91687076339821 0.600220619888076 0.3125 17.2 17 2 abnormal phalanx morphology 0.718197398247825 0.919936162791692 0.600220619888076 0.3125 17.2 17 2 abnormal inhibitory postsynaptic currents 0.759464318732006 0.958724939277273 0.593159200830569 0.308823529411765 17.2 17 2 abnormal tectorial membrane morphology 0.713408191845162 0.91687076339821 0.590986456505182 0.307692307692308 17.2 17 2 blistering 0.721576162418699 0.921269337167398 0.584562690673604 0.304347826086957 17.2 17 2 decreased skin tensile strength 0.731701778342586 0.933867713508046 0.576211795092553 0.3 17.2 17 2 abnormal estrous cycle 0.748459734461286 0.950802675850165 0.576211795092553 0.3 17.2 17 2 abnormal synaptic transmission 0.748459734461286 0.950802675850165 0.576211795092553 0.3 17.2 17 2 head bobbing 0.76513045186607 0.964409424381479 0.576211795092553 0.3 17.2 17 2 increased aggression towards mice 0.744573180086033 0.949078035082761 0.564913524600542 0.294117647058824 17.2 17 2 abnormal heart rate 0.744573180086033 0.949078035082761 0.564913524600542 0.294117647058824 17.2 17 2 abnormal touch/ nociception 0.744573180086033 0.949078035082761 0.564913524600542 0.294117647058824 17.2 17 2 abnormal duodenum morphology 0.744573180086033 0.949078035082761 0.564913524600542 0.294117647058824 17.2 17 2 abnormal tendon morphology 0.744573180086033 0.949078035082761 0.564913524600542 0.294117647058824 17.2 17 2 impaired synaptic plasticity 0.778043254101228 0.980188703254902 0.564913524600542 0.294117647058824 17.2 17 2 decreased pancreatic beta cell number 0.778043254101228 0.980188703254902 0.564913524600542 0.294117647058824 17.2 17 2 abnormal autopod morphology 0.818857807134231 0.99520676184387 0.554870617496532 0.288888888888889 17.2 17 2 impaired behavioral response to xenobiotic 0.81072446357563 0.994749706124583 0.548773138183384 0.285714285714286 17.2 17 2 abnormal long term potentiation 0.819109005368068 0.99520676184387 0.540198557899268 0.28125 17.2 17 2 acidosis 0.792751732549661 0.994749706124583 0.533529439900512 0.277777777777778 17.2 17 2 abnormal body wall morphology 0.792751732549661 0.994749706124583 0.533529439900512 0.277777777777778 17.2 17 2 abnormal ocular fundus morphology 0.839652972669823 1 0.517113149442034 0.269230769230769 17.2 17 2 decreased chemically-elicited antinociception 0.833484940543027 1 0.505448943063643 0.263157894736842 17.2 17 2 abnormal behavioral response to xenobiotic 0.833484940543027 1 0.505448943063643 0.263157894736842 17.2 17 2 abnormal single cell response 0.868707744562076 1 0.497960810573811 0.259259259259259 17.2 17 2 syndactyly 0.944286113701786 1 0.488315080586909 0.254237288135593 17.2 17 2 abnormal nest building behavior 0.904913921244442 1 0.460969436074042 0.24 17.2 17 2 abnormal systemic arterial blood pressure 0.959404242359362 1 0.426823551920409 0.222222222222222 17.2 17 2 abnormal regulatory T cell physiology 0.936155849493278 1 0.417544779052574 0.217391304347826 17.2 17 2 increased stereotypic behavior 0.950645826065756 1 0.400147079925384 0.208333333333333 17.2 17 2 impaired conditioned place preference behavior 0.962078802271084 1 0.384141196728368 0.2 17.2 17 2 increased circulating luteinizing hormone level 0.983349261666845 1 0.342983211364615 0.178571428571429 17.2 17 2 spleen atrophy 3.96637716342702e-07 8.2910615075838e-06 1.08904489192684 1 17.5 17 5 abnormal thymocyte activation 3.96637716342702e-07 8.2910615075838e-06 1.08904489192684 1 17.5 17 5 axonal dystrophy 6.91179853561791e-05 0.00084073833043274 1.08904489192684 1 17.5 17 5 absent CD4-positive, alpha beta T cells 0.000630804386559609 0.00556427628215258 1.08904489192684 1 17.5 17 5 abnormal corneal endothelium morphology 0.000630804386559609 0.00556427628215258 1.08904489192684 1 17.5 17 5 increased platelet aggregation 0.000630804386559609 0.00556427628215258 1.08904489192684 1 17.5 17 5 decreased transitional stage T2 B cell number 0.000630804386559609 0.00556427628215258 1.08904489192684 1 17.5 17 5 increased T-helper 17 cell number 0.000630804386559609 0.00556427628215258 1.08904489192684 1 17.5 17 5 abnormal left subclavian artery morphology 0.000630804386559609 0.00556427628215258 1.08904489192684 1 17.5 17 5 abnormal inferior vena cava valve morphology 0.000630804386559609 0.00556427628215258 1.08904489192684 1 17.5 17 5 decreased macrophage cytokine production 0.000630804386559609 0.00556427628215258 1.08904489192684 1 17.5 17 5 lethality during fetal growth through weaning, complete penetrance 0.000630804386559609 0.00556427628215258 1.08904489192684 1 17.5 17 5 increased fatty acid oxidation 0.000630804386559609 0.00556427628215258 1.08904489192684 1 17.5 17 5 abnormal eyelid aperture 0.00275440219083234 0.0187971891624017 1.08904489192684 1 17.5 17 5 elevated level of mitotic sister chromatid exchange 0.00275440219083234 0.0187971891624017 1.08904489192684 1 17.5 17 5 lymph node inflammation 0.00275440219083234 0.0187971891624017 1.08904489192684 1 17.5 17 5 accumulation of giant lysosomes in kidney/renal tubule cells 0.00275440219083234 0.0187971891624017 1.08904489192684 1 17.5 17 5 abnormal NK cell morphology 0.00275440219083234 0.0187971891624017 1.08904489192684 1 17.5 17 5 decreased susceptibility to autoimmune disorder 0.00275440219083234 0.0187971891624017 1.08904489192684 1 17.5 17 5 abnormal mitotic spindle assembly checkpoint 0.00275440219083234 0.0187971891624017 1.08904489192684 1 17.5 17 5 abnormal olfactory bulb mitral cell layer morphology 0.00275440219083234 0.0187971891624017 1.08904489192684 1 17.5 17 5 abnormal cerebellum deep nucleus morphology 0.00275440219083234 0.0187971891624017 1.08904489192684 1 17.5 17 5 pleural effusion 0.00275440219083234 0.0187971891624017 1.08904489192684 1 17.5 17 5 abnormal macrophage activation involved in immune response 0.00275440219083234 0.0187971891624017 1.08904489192684 1 17.5 17 5 embryo cyst 0.00275440219083234 0.0187971891624017 1.08904489192684 1 17.5 17 5 increased brain apoptosis 0.00275440219083234 0.0187971891624017 1.08904489192684 1 17.5 17 5 abnormal pineal gland morphology 0.0251259041082234 0.113361182067823 1.08904489192684 1 17.5 17 5 decreased sensitivity to skin irradiation 0.0251259041082234 0.113361182067823 1.08904489192684 1 17.5 17 5 skin hyperplasia 0.0251259041082234 0.113361182067823 1.08904489192684 1 17.5 17 5 kinked vibrissae 0.0251259041082234 0.113361182067823 1.08904489192684 1 17.5 17 5 corneal scarring 0.0251259041082234 0.113361182067823 1.08904489192684 1 17.5 17 5 abnormal penile erection 0.0251259041082234 0.113361182067823 1.08904489192684 1 17.5 17 5 sinus inflammation 0.0251259041082234 0.113361182067823 1.08904489192684 1 17.5 17 5 abnormal respiratory sounds 0.0251259041082234 0.113361182067823 1.08904489192684 1 17.5 17 5 increased hepatic hemangioma incidence 0.0251259041082234 0.113361182067823 1.08904489192684 1 17.5 17 5 abnormal oropharynx morphology 0.0251259041082234 0.113361182067823 1.08904489192684 1 17.5 17 5 abnormal sebaceous gland physiology 0.0251259041082234 0.113361182067823 1.08904489192684 1 17.5 17 5 decreased lysosomal enzyme secretion 0.0251259041082234 0.113361182067823 1.08904489192684 1 17.5 17 5 increased lysosomal enzyme secretion 0.0251259041082234 0.113361182067823 1.08904489192684 1 17.5 17 5 gastric polyps 0.0251259041082234 0.113361182067823 1.08904489192684 1 17.5 17 5 sirenomelia 0.0251259041082234 0.113361182067823 1.08904489192684 1 17.5 17 5 ischuria 0.0251259041082234 0.113361182067823 1.08904489192684 1 17.5 17 5 abnormal response to vitamins 0.0251259041082234 0.113361182067823 1.08904489192684 1 17.5 17 5 decreased autoantibody level 0.0251259041082234 0.113361182067823 1.08904489192684 1 17.5 17 5 abnormal urinary system development 0.0251259041082234 0.113361182067823 1.08904489192684 1 17.5 17 5 absent frontal bone 0.0251259041082234 0.113361182067823 1.08904489192684 1 17.5 17 5 abnormal T cell selection 0.0251259041082234 0.113361182067823 1.08904489192684 1 17.5 17 5 decreased unsaturated fatty acid level 0.0251259041082234 0.113361182067823 1.08904489192684 1 17.5 17 5 corneal deposits 0.0251259041082234 0.113361182067823 1.08904489192684 1 17.5 17 5 abnormal hemoglobin content 0.0251259041082234 0.113361182067823 1.08904489192684 1 17.5 17 5 increased placenta apoptosis 0.0251259041082234 0.113361182067823 1.08904489192684 1 17.5 17 5 enlarged eye anterior chamber 0.0251259041082234 0.113361182067823 1.08904489192684 1 17.5 17 5 abnormal tail hair pigmentation 0.0251259041082234 0.113361182067823 1.08904489192684 1 17.5 17 5 aciduria 0.0251259041082234 0.113361182067823 1.08904489192684 1 17.5 17 5 decreased DN3 thymocyte number 0.0251259041082234 0.113361182067823 1.08904489192684 1 17.5 17 5 increased response to stress-induced hyperthermia 0.0251259041082234 0.113361182067823 1.08904489192684 1 17.5 17 5 increased T follicular helper cell number 0.0251259041082234 0.113361182067823 1.08904489192684 1 17.5 17 5 abnormal lymphatic vessel endothelial cell morphology 0.0251259041082234 0.113361182067823 1.08904489192684 1 17.5 17 5 increased thyroid carcinoma incidence 0.0251259041082234 0.113361182067823 1.08904489192684 1 17.5 17 5 aorta hypoplasia 0.0251259041082234 0.113361182067823 1.08904489192684 1 17.5 17 5 prolonged ST segment 0.0251259041082234 0.113361182067823 1.08904489192684 1 17.5 17 5 decreased heart left ventricle size 0.0251259041082234 0.113361182067823 1.08904489192684 1 17.5 17 5 enlarged aortic valve 0.0251259041082234 0.113361182067823 1.08904489192684 1 17.5 17 5 increased CD4-positive, alpha-beta memory T cell number 0.0251259041082234 0.113361182067823 1.08904489192684 1 17.5 17 5 pulmonary alveolar edema 0.0251259041082234 0.113361182067823 1.08904489192684 1 17.5 17 5 decreased pre-pro B cell number 0.0251259041082234 0.113361182067823 1.08904489192684 1 17.5 17 5 decreased small intestinal villus height 0.0251259041082234 0.113361182067823 1.08904489192684 1 17.5 17 5 decreased B-1 B cell number 3.24858175692705e-13 1.87926677217582e-11 1.08904489192684 1 17.5 17 5 abnormal T cell proliferation 1.18885814558303e-10 4.54966867251966e-09 1.08904489192684 1 17.5 17 5 decreased tumor incidence 8.2909998598023e-07 1.6632146896176e-05 1.08904489192684 1 17.5 17 5 abnormal dendritic cell morphology 1.58240942645035e-05 0.00023928531600579 1.08904489192684 1 17.5 17 5 increased hemangioma incidence 3.30721131900964e-05 0.000453261055429007 1.08904489192684 1 17.5 17 5 abnormal maternal decidual layer morphology 3.30721131900964e-05 0.000453261055429007 1.08904489192684 1 17.5 17 5 abnormal positive T cell selection 3.30721131900964e-05 0.000453261055429007 1.08904489192684 1 17.5 17 5 increased osteosarcoma incidence 0.000144446238947356 0.00161125569229393 1.08904489192684 1 17.5 17 5 decreased red blood cell distribution width 0.000144446238947356 0.00161125569229393 1.08904489192684 1 17.5 17 5 abnormal thrombopoiesis 0.000301861307704072 0.00299155379646964 1.08904489192684 1 17.5 17 5 loss of cortex neurons 0.000301861307704072 0.00299155379646964 1.08904489192684 1 17.5 17 5 heart hyperplasia 0.00131815962847623 0.0103599433675659 1.08904489192684 1 17.5 17 5 abnormal gut-associated lymphoid tissue morphology 0.00131815962847623 0.0103599433675659 1.08904489192684 1 17.5 17 5 increased neuronal precursor cell number 0.00131815962847623 0.0103599433675659 1.08904489192684 1 17.5 17 5 liver hyperplasia 0.00131815962847623 0.0103599433675659 1.08904489192684 1 17.5 17 5 decreased transitional stage T1 B cell number 0.00131815962847623 0.0103599433675659 1.08904489192684 1 17.5 17 5 decreased fatty acid oxidation 0.00131815962847623 0.0103599433675659 1.08904489192684 1 17.5 17 5 decreased platelet dense granule number 0.00131815962847623 0.0103599433675659 1.08904489192684 1 17.5 17 5 broad head 0.00575536342449855 0.0348887540365764 1.08904489192684 1 17.5 17 5 skin photosensitivity 0.00575536342449855 0.0348887540365764 1.08904489192684 1 17.5 17 5 decreased activated T cell number 0.00575536342449855 0.0348887540365764 1.08904489192684 1 17.5 17 5 abnormal tumor incidence 0.00575536342449855 0.0348887540365764 1.08904489192684 1 17.5 17 5 abnormal hypersensitivity reaction 0.00575536342449855 0.0348887540365764 1.08904489192684 1 17.5 17 5 abnormal brain ventricular system morphology 0.00575536342449855 0.0348887540365764 1.08904489192684 1 17.5 17 5 decreased mortality induced by ionizing radiation 0.00575536342449855 0.0348887540365764 1.08904489192684 1 17.5 17 5 increased cell nucleus count 0.00575536342449855 0.0348887540365764 1.08904489192684 1 17.5 17 5 abnormal negative T cell selection 0.00575536342449855 0.0348887540365764 1.08904489192684 1 17.5 17 5 increased keratinocyte apoptosis 0.00575536342449855 0.0348887540365764 1.08904489192684 1 17.5 17 5 heart hemorrhage 0.00575536342449855 0.0348887540365764 1.08904489192684 1 17.5 17 5 increased tumor latency 0.00575536342449855 0.0348887540365764 1.08904489192684 1 17.5 17 5 decreased DN2 thymocyte number 0.00575536342449855 0.0348887540365764 1.08904489192684 1 17.5 17 5 decreased brain cholesterol level 0.00575536342449855 0.0348887540365764 1.08904489192684 1 17.5 17 5 decreased T-helper 17 cell number 0.00575536342449855 0.0348887540365764 1.08904489192684 1 17.5 17 5 abnormal outer hair cell kinocilium morphology 0.00575536342449855 0.0348887540365764 1.08904489192684 1 17.5 17 5 decreased CD8-positive, naive alpha-beta T cell number 0.00575536342449855 0.0348887540365764 1.08904489192684 1 17.5 17 5 ductus venosus stenosis 0.00575536342449855 0.0348887540365764 1.08904489192684 1 17.5 17 5 delayed brain development 0.0120255292695214 0.0640546125437572 1.08904489192684 1 17.5 17 5 non-obstructive hydrocephaly 0.0120255292695214 0.0640546125437572 1.08904489192684 1 17.5 17 5 abnormal lymph node cortex morphology 0.0120255292695214 0.0640546125437572 1.08904489192684 1 17.5 17 5 calcified joint 0.0120255292695214 0.0640546125437572 1.08904489192684 1 17.5 17 5 abnormal leukocyte tethering or rolling 0.0120255292695214 0.0640546125437572 1.08904489192684 1 17.5 17 5 absent parietal bone 0.0120255292695214 0.0640546125437572 1.08904489192684 1 17.5 17 5 abnormal T cell clonal deletion 0.0120255292695214 0.0640546125437572 1.08904489192684 1 17.5 17 5 abnormal immature B cell morphology 0.0120255292695214 0.0640546125437572 1.08904489192684 1 17.5 17 5 impaired granulocyte bactericidal activity 0.0120255292695214 0.0640546125437572 1.08904489192684 1 17.5 17 5 abnormal eyelid development 0.0120255292695214 0.0640546125437572 1.08904489192684 1 17.5 17 5 increased transitional stage T1 B cell number 0.0120255292695214 0.0640546125437572 1.08904489192684 1 17.5 17 5 abnormal olfactory bulb layer morphology 0.0120255292695214 0.0640546125437572 1.08904489192684 1 17.5 17 5 enlarged lymphatic vessel 0.0120255292695214 0.0640546125437572 1.08904489192684 1 17.5 17 5 kidney microaneurysm 0.0120255292695214 0.0640546125437572 1.08904489192684 1 17.5 17 5 cerebral arteriovenous malformation 0.0120255292695214 0.0640546125437572 1.08904489192684 1 17.5 17 5 decreased macrophage nitric oxide production 0.0120255292695214 0.0640546125437572 1.08904489192684 1 17.5 17 5 delayed limb development 0.0120255292695214 0.0640546125437572 1.08904489192684 1 17.5 17 5 thymus cortex atrophy 0.0120255292695214 0.0640546125437572 1.08904489192684 1 17.5 17 5 increased CD11b-high dendritic cell number 0.0120255292695214 0.0640546125437572 1.08904489192684 1 17.5 17 5 abnormal vertebral artery origin 0.0120255292695214 0.0640546125437572 1.08904489192684 1 17.5 17 5 decreased tear production 0.0120255292695214 0.0640546125437572 1.08904489192684 1 17.5 17 5 abnormal cytotoxic T cell physiology 1.66316932949075e-12 8.53017259197575e-11 1.06311525164287 0.976190476190476 17.5 17 5 increased thymocyte apoptosis 1.39496063051366e-07 3.15451324400249e-06 1.04715854992966 0.961538461538462 17.5 17 5 increased B cell derived lymphoma incidence 1.46733105699869e-13 9.12496501071058e-12 1.04548309624977 0.96 17.5 17 5 increased pre-B cell number 2.8079592174022e-07 6.04744463488136e-06 1.04548309624977 0.96 17.5 17 5 increased hemangiosarcoma incidence 5.64363198091091e-07 1.1554349425939e-05 1.04366802142989 0.958333333333333 17.5 17 5 abnormal lymphocyte physiology 2.38236271971822e-12 1.19719742733315e-10 1.04169511401698 0.956521739130435 17.5 17 5 abnormal B cell morphology 1.13243324128335e-06 2.20072475600964e-05 1.04169511401698 0.956521739130435 17.5 17 5 increased incidence of induced tumors 4.53451998009962e-06 7.64719894949004e-05 1.0371856113589 0.952380952380952 17.5 17 5 increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 1.80037520906068e-05 0.000266573412651097 1.03172673972017 0.947368421052632 17.5 17 5 abnormal lysosome morphology 2.3499447784675e-09 7.36354630891613e-08 1.02854239793091 0.944444444444444 17.5 17 5 abnormal megakaryocyte differentiation 3.57408662783828e-05 0.000476704583739824 1.02854239793091 0.944444444444444 17.5 17 5 abnormal Peyer's patch follicle morphology 3.57408662783828e-05 0.000476704583739824 1.02854239793091 0.944444444444444 17.5 17 5 decreased cellular sensitivity to gamma-irradiation 3.57408662783828e-05 0.000476704583739824 1.02854239793091 0.944444444444444 17.5 17 5 decreased tumor latency 3.57408662783828e-05 0.000476704583739824 1.02854239793091 0.944444444444444 17.5 17 5 increased effector memory CD4-positive, alpha-beta T cell number 3.57408662783828e-05 0.000476704583739824 1.02854239793091 0.944444444444444 17.5 17 5 abnormal hypoglossal nerve topology 3.57408662783828e-05 0.000476704583739824 1.02854239793091 0.944444444444444 17.5 17 5 abnormal bone marrow cavity morphology 7.07518866132377e-05 0.000858513746099653 1.02498342769585 0.941176470588235 17.5 17 5 abnormal T cell subpopulation ratio 1.80961710066229e-08 5.20395669121093e-07 1.023042171204 0.939393939393939 17.5 17 5 increased cochlear outer hair cell number 0.000139618267080458 0.00158223434789357 1.02097958618142 0.9375 17.5 17 5 abnormal level of surface class II molecules 0.000139618267080458 0.00158223434789357 1.02097958618142 0.9375 17.5 17 5 decreased liver cholesterol level 0.000139618267080458 0.00158223434789357 1.02097958618142 0.9375 17.5 17 5 decreased B cell proliferation 1.80335678568238e-18 2.24292500219246e-16 1.02011800003274 0.936708860759494 17.5 17 5 autoimmune response 6.9940465726405e-08 1.75734251004477e-06 1.01878393115737 0.935483870967742 17.5 17 5 abnormal B cell differentiation 8.23360799400112e-21 1.2412787809138e-18 1.01723973421738 0.934065934065934 17.5 17 5 decreased hepatocyte number 0.000274544378148398 0.00275087507951204 1.01644189913172 0.933333333333333 17.5 17 5 abnormal placenta size 0.000274544378148398 0.00275087507951204 1.01644189913172 0.933333333333333 17.5 17 5 heterochrony 0.000274544378148398 0.00275087507951204 1.01644189913172 0.933333333333333 17.5 17 5 abnormal T cell activation 5.20701605765865e-17 5.39685518476079e-15 1.01546077760746 0.932432432432432 17.5 17 5 decreased double-positive T cell number 2.80157561659765e-22 6.05992986633622e-20 1.01281174949196 0.93 17.5 17 5 spina bifida 5.6823253083407e-10 2.06347214664197e-08 1.01125597107493 0.928571428571429 17.5 17 5 lymphoid hyperplasia 5.23123472221146e-07 1.07542945219017e-05 1.01125597107493 0.928571428571429 17.5 17 5 subcutaneous edema 5.23123472221146e-07 1.07542945219017e-05 1.01125597107493 0.928571428571429 17.5 17 5 midline facial cleft 0.000537714323515253 0.0048995032225062 1.01125597107493 0.928571428571429 17.5 17 5 abnormal spleen periarteriolar lymphoid sheath morphology 0.000537714323515253 0.0048995032225062 1.01125597107493 0.928571428571429 17.5 17 5 vascular smooth muscle hypoplasia 0.000537714323515253 0.0048995032225062 1.01125597107493 0.928571428571429 17.5 17 5 increased B-1 B cell number 0.000537714323515253 0.0048995032225062 1.01125597107493 0.928571428571429 17.5 17 5 lysosomal protein accumulation 0.000537714323515253 0.0048995032225062 1.01125597107493 0.928571428571429 17.5 17 5 testis degeneration 0.000537714323515253 0.0048995032225062 1.01125597107493 0.928571428571429 17.5 17 5 decreased response to antigen 0.000537714323515253 0.0048995032225062 1.01125597107493 0.928571428571429 17.5 17 5 abnormal fetal cardiomyocyte proliferation 1.01817043063402e-06 2.00213355430999e-05 1.00837489993226 0.925925925925926 17.5 17 5 abnormal tail bud morphology 0.00104838528204148 0.00864961323077339 1.00527220793247 0.923076923076923 17.5 17 5 absent hypoglossal nerve 0.00104838528204148 0.00864961323077339 1.00527220793247 0.923076923076923 17.5 17 5 impaired hematopoiesis 1.77657312989299e-11 7.82163833736071e-10 1.00362960628552 0.92156862745098 17.5 17 5 abnormal cell morphology 4.37584822324596e-24 1.08849224553243e-21 1.00306766361683 0.921052631578947 17.5 17 5 decreased T cell proliferation 1.52639890531349e-30 6.32819546161219e-28 1.00074395474359 0.918918918918919 17.5 17 5 abnormal NK cell physiology 2.88736558477382e-13 1.71007664098211e-11 0.999778917178741 0.918032786885246 17.5 17 5 abnormal thymus involution 0.00203342706402795 0.01478991175956 0.998291150932939 0.916666666666667 17.5 17 5 increased papilloma incidence 0.00203342706402795 0.01478991175956 0.998291150932939 0.916666666666667 17.5 17 5 abnormal embryonic growth/weight/body size 0.00203342706402795 0.01478991175956 0.998291150932939 0.916666666666667 17.5 17 5 abnormal vascular endothelial cell development 0.00203342706402795 0.01478991175956 0.998291150932939 0.916666666666667 17.5 17 5 delayed somite formation 0.00203342706402795 0.01478991175956 0.998291150932939 0.916666666666667 17.5 17 5 abnormal rostral-caudal body axis extension 0.00203342706402795 0.01478991175956 0.998291150932939 0.916666666666667 17.5 17 5 abnormal B cell proliferation 0.00203342706402795 0.01478991175956 0.998291150932939 0.916666666666667 17.5 17 5 abnormal fatty acid level 0.00203342706402795 0.01478991175956 0.998291150932939 0.916666666666667 17.5 17 5 increased fibrosarcoma incidence 0.00203342706402795 0.01478991175956 0.998291150932939 0.916666666666667 17.5 17 5 persistent right dorsal aorta 0.00203342706402795 0.01478991175956 0.998291150932939 0.916666666666667 17.5 17 5 abnormal pulmonary valve cusp morphology 0.00203342706402795 0.01478991175956 0.998291150932939 0.916666666666667 17.5 17 5 prenatal growth retardation 0.00203342706402795 0.01478991175956 0.998291150932939 0.916666666666667 17.5 17 5 abnormal vitelline vein connection 0.00203342706402795 0.01478991175956 0.998291150932939 0.916666666666667 17.5 17 5 increased T cell proliferation 4.31702878717641e-22 8.59088728648105e-20 0.997442985129258 0.91588785046729 17.5 17 5 abnormal CD4-positive, alpha-beta T cell physiology 4.72977749205681e-15 3.67666297234103e-13 0.9970129292288 0.915492957746479 17.5 17 5 increased B cell proliferation 1.06706886184242e-12 5.52986207048544e-11 0.996752951933043 0.915254237288136 17.5 17 5 increased hepatocellular carcinoma incidence 3.91967075393839e-12 1.83965679253241e-10 0.993514638249049 0.912280701754386 17.5 17 5 decreased cytotoxic T cell cytolysis 1.10237468579115e-07 2.55084374967952e-06 0.992952695580357 0.911764705882353 17.5 17 5 increased activated T cell number 2.71971237171999e-05 0.000379007536395153 0.990040810842584 0.909090909090909 17.5 17 5 abnormal lysosome physiology 2.71971237171999e-05 0.000379007536395153 0.990040810842584 0.909090909090909 17.5 17 5 decreased susceptibility to viral infection induced morbidity/mortality 2.71971237171999e-05 0.000379007536395153 0.990040810842584 0.909090909090909 17.5 17 5 impaired humoral immune response 2.71971237171999e-05 0.000379007536395153 0.990040810842584 0.909090909090909 17.5 17 5 delayed hepatic development 0.00392023517511498 0.0255277094191061 0.990040810842584 0.909090909090909 17.5 17 5 vasculitis 0.00392023517511498 0.0255277094191061 0.990040810842584 0.909090909090909 17.5 17 5 increased number of Howell-Jolly bodies 0.00392023517511498 0.0255277094191061 0.990040810842584 0.909090909090909 17.5 17 5 aorta dilation 0.00392023517511498 0.0255277094191061 0.990040810842584 0.909090909090909 17.5 17 5 decreased embryonic cilium length 0.00392023517511498 0.0255277094191061 0.990040810842584 0.909090909090909 17.5 17 5 thin hypoglossal nerve 0.00392023517511498 0.0255277094191061 0.990040810842584 0.909090909090909 17.5 17 5 reduced sympathetic cervical ganglion size 0.00392023517511498 0.0255277094191061 0.990040810842584 0.909090909090909 17.5 17 5 spleen hyperplasia 3.77228480961349e-15 3.02695434319792e-13 0.987400702013671 0.906666666666667 17.5 17 5 increased fibroblast apoptosis 4.01798244809451e-07 8.36379191601262e-06 0.986946933308701 0.90625 17.5 17 5 abnormal erythropoiesis 1.69119070196182e-20 2.40390678350288e-18 0.985326330790953 0.904761904761905 17.5 17 5 liver hypoplasia 9.84222482867676e-11 3.88611654941801e-09 0.984329036933877 0.903846153846154 17.5 17 5 decreased IgA level 9.84222482867676e-11 3.88611654941801e-09 0.984329036933877 0.903846153846154 17.5 17 5 increased double-negative T cell number 3.00058856449002e-12 1.44931340857649e-10 0.981925722229121 0.901639344262295 17.5 17 5 increased skin tumor incidence 9.86245729242289e-05 0.00115994621819867 0.980140402734159 0.9 17.5 17 5 absent ductus venosus valve 9.86245729242289e-05 0.00115994621819867 0.980140402734159 0.9 17.5 17 5 kidney hemorrhage 0.0075043568057258 0.0434118315214952 0.980140402734159 0.9 17.5 17 5 abnormal immune cell physiology 0.0075043568057258 0.0434118315214952 0.980140402734159 0.9 17.5 17 5 impaired social transmission of food preference 0.0075043568057258 0.0434118315214952 0.980140402734159 0.9 17.5 17 5 bifid ureter 0.0075043568057258 0.0434118315214952 0.980140402734159 0.9 17.5 17 5 increased heart rate variability 0.0075043568057258 0.0434118315214952 0.980140402734159 0.9 17.5 17 5 abnormal gas homeostasis 0.0075043568057258 0.0434118315214952 0.980140402734159 0.9 17.5 17 5 absent inguinal lymph nodes 0.0075043568057258 0.0434118315214952 0.980140402734159 0.9 17.5 17 5 increased circulating fructosamine level 0.0075043568057258 0.0434118315214952 0.980140402734159 0.9 17.5 17 5 thick aortic valve cusps 0.0075043568057258 0.0434118315214952 0.980140402734159 0.9 17.5 17 5 increased hepatocyte apoptosis 4.20735916576284e-08 1.08453947407617e-06 0.977347979934346 0.897435897435897 17.5 17 5 increased mortality induced by gamma-irradiation 2.73328945782199e-06 4.85646966166586e-05 0.976385075520618 0.896551724137931 17.5 17 5 increased double-positive T cell number 2.73328945782199e-06 4.85646966166586e-05 0.976385075520618 0.896551724137931 17.5 17 5 vertebral transformation 1.25279229901159e-09 4.18298099837763e-08 0.975602715684463 0.895833333333333 17.5 17 5 abnormal cell cycle 2.69157940450601e-21 4.18456485544293e-19 0.975405424943172 0.895652173913044 17.5 17 5 small superior vagus ganglion 0.000186506336874477 0.00200403677311129 0.974408587513491 0.894736842105263 17.5 17 5 increased liver adenoma incidence 0.000186506336874477 0.00200403677311129 0.974408587513491 0.894736842105263 17.5 17 5 abnormal blastocyst morphology 0.000186506336874477 0.00200403677311129 0.974408587513491 0.894736842105263 17.5 17 5 increased cellular sensitivity to gamma-irradiation 2.35337459923149e-09 7.36354630891613e-08 0.973189052360157 0.893617021276596 17.5 17 5 pale liver 6.67162883778403e-14 4.42551379573007e-12 0.971310309015833 0.891891891891892 17.5 17 5 abnormal T cell differentiation 1.99636180538927e-18 2.42241462971015e-16 0.970436042311048 0.891089108910891 17.5 17 5 abnormal apoptosis 2.4853419142712e-10 9.36710304810546e-09 0.968039903934971 0.888888888888889 17.5 17 5 decreased circulating fructosamine level 9.64218458898594e-06 0.000153749577981426 0.968039903934971 0.888888888888889 17.5 17 5 underdeveloped hair follicles 0.000350840049292079 0.00340239618952844 0.968039903934971 0.888888888888889 17.5 17 5 abnormal thymus cortex morphology 0.000350840049292079 0.00340239618952844 0.968039903934971 0.888888888888889 17.5 17 5 absent inner cell mass 0.000350840049292079 0.00340239618952844 0.968039903934971 0.888888888888889 17.5 17 5 abnormal neutrophil morphology 0.000350840049292079 0.00340239618952844 0.968039903934971 0.888888888888889 17.5 17 5 small thoracic cage 0.000350840049292079 0.00340239618952844 0.968039903934971 0.888888888888889 17.5 17 5 distorted hair follicle pattern 0.0142443426896812 0.0721645670887618 0.968039903934971 0.888888888888889 17.5 17 5 crypts of Lieberkuhn abscesses 0.0142443426896812 0.0721645670887618 0.968039903934971 0.888888888888889 17.5 17 5 decreased level of surface class I molecules 0.0142443426896812 0.0721645670887618 0.968039903934971 0.888888888888889 17.5 17 5 abnormal thymus physiology 0.0142443426896812 0.0721645670887618 0.968039903934971 0.888888888888889 17.5 17 5 decreased cellular sensitivity to ionizing radiation 0.0142443426896812 0.0721645670887618 0.968039903934971 0.888888888888889 17.5 17 5 abnormal CNS synapse formation 0.0142443426896812 0.0721645670887618 0.968039903934971 0.888888888888889 17.5 17 5 abnormal leukopoiesis 0.0142443426896812 0.0721645670887618 0.968039903934971 0.888888888888889 17.5 17 5 abnormal liver vasculature morphology 0.0142443426896812 0.0721645670887618 0.968039903934971 0.888888888888889 17.5 17 5 eye opacity 0.0142443426896812 0.0721645670887618 0.968039903934971 0.888888888888889 17.5 17 5 abnormal telomere morphology 0.0142443426896812 0.0721645670887618 0.968039903934971 0.888888888888889 17.5 17 5 abnormal ventricle myocardium morphology 0.0142443426896812 0.0721645670887618 0.968039903934971 0.888888888888889 17.5 17 5 decreased effector memory CD4-positive, alpha-beta T cell number 0.0142443426896812 0.0721645670887618 0.968039903934971 0.888888888888889 17.5 17 5 abnormal oxidative phosphorylation 0.0142443426896812 0.0721645670887618 0.968039903934971 0.888888888888889 17.5 17 5 abnormal lung lobe morphology 0.0142443426896812 0.0721645670887618 0.968039903934971 0.888888888888889 17.5 17 5 abnormal ductus venosus valve topology 0.0142443426896812 0.0721645670887618 0.968039903934971 0.888888888888889 17.5 17 5 abnormal infrahyoid muscle connection 0.0142443426896812 0.0721645670887618 0.968039903934971 0.888888888888889 17.5 17 5 increased cardiac muscle glycogen level 0.0142443426896812 0.0721645670887618 0.968039903934971 0.888888888888889 17.5 17 5 decreased IgM level 2.4168217311486e-17 2.55823151329028e-15 0.965544955728953 0.88659793814433 17.5 17 5 embryonic lethality between somite formation and embryo turning, complete penetrance 8.07743793970503e-13 4.23002671052974e-11 0.964582618563775 0.885714285714286 17.5 17 5 increased leukemia incidence 1.800099719371e-05 0.000266573412651097 0.963385865935284 0.884615384615385 17.5 17 5 decreased circulating glycerol level 1.800099719371e-05 0.000266573412651097 0.963385865935284 0.884615384615385 17.5 17 5 decreased Peyer's patch number 1.800099719371e-05 0.000266573412651097 0.963385865935284 0.884615384615385 17.5 17 5 decreased IgG level 2.81026623586557e-19 3.58489090344391e-17 0.961499093773249 0.882882882882883 17.5 17 5 abnormal direction of heart looping 9.64612235761095e-07 1.91193062665795e-05 0.960921963464861 0.882352941176471 17.5 17 5 decreased regulatory T cell number 9.64612235761095e-07 1.91193062665795e-05 0.960921963464861 0.882352941176471 17.5 17 5 abnormal embryonic-extraembryonic boundary morphology 0.000656116120584605 0.00570644592566882 0.960921963464861 0.882352941176471 17.5 17 5 increased regulatory T cell number 0.000656116120584605 0.00570644592566882 0.960921963464861 0.882352941176471 17.5 17 5 increased cellular sensitivity to ionizing radiation 3.34571938783938e-05 0.000456026135739751 0.958359504895622 0.88 17.5 17 5 decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 3.34571938783938e-05 0.000456026135739751 0.958359504895622 0.88 17.5 17 5 arrested B cell differentiation 9.79738927727898e-08 2.31004794570914e-06 0.956234539252838 0.878048780487805 17.5 17 5 extramedullary hematopoiesis 6.0473448298743e-18 6.83762284741469e-16 0.955482782539589 0.877358490566038 17.5 17 5 incomplete embryo turning 3.08068509484814e-10 1.14376181693056e-08 0.955302536777932 0.87719298245614 17.5 17 5 impaired natural killer cell mediated cytotoxicity 3.08068509484814e-10 1.14376181693056e-08 0.955302536777932 0.87719298245614 17.5 17 5 abnormal embryonic hematopoiesis 3.29756494630664e-06 5.73614881394249e-05 0.952914280435987 0.875 17.5 17 5 abnormal bone marrow cell number 0.00121902715562398 0.00979751227662244 0.952914280435987 0.875 17.5 17 5 disorganized yolk sac vascular plexus 0.00121902715562398 0.00979751227662244 0.952914280435987 0.875 17.5 17 5 intraventricular hemorrhage 0.00121902715562398 0.00979751227662244 0.952914280435987 0.875 17.5 17 5 large intestinal inflammation 0.00121902715562398 0.00979751227662244 0.952914280435987 0.875 17.5 17 5 schistocytosis 0.026762092060162 0.115976836236329 0.952914280435987 0.875 17.5 17 5 abnormal vagus ganglion morphology 0.026762092060162 0.115976836236329 0.952914280435987 0.875 17.5 17 5 increased sensitivity to skin irradiation 0.026762092060162 0.115976836236329 0.952914280435987 0.875 17.5 17 5 dermal cysts 0.026762092060162 0.115976836236329 0.952914280435987 0.875 17.5 17 5 altered response to CNS ischemic injury 0.026762092060162 0.115976836236329 0.952914280435987 0.875 17.5 17 5 colon polyps 0.026762092060162 0.115976836236329 0.952914280435987 0.875 17.5 17 5 liver failure 0.026762092060162 0.115976836236329 0.952914280435987 0.875 17.5 17 5 binucleate 0.026762092060162 0.115976836236329 0.952914280435987 0.875 17.5 17 5 abnormal extraembryonic tissue physiology 0.026762092060162 0.115976836236329 0.952914280435987 0.875 17.5 17 5 abnormal kidney epithelium morphology 0.026762092060162 0.115976836236329 0.952914280435987 0.875 17.5 17 5 abnormal somite size 0.026762092060162 0.115976836236329 0.952914280435987 0.875 17.5 17 5 abnormal vertebral body development 0.026762092060162 0.115976836236329 0.952914280435987 0.875 17.5 17 5 craniofacial phenotype 0.026762092060162 0.115976836236329 0.952914280435987 0.875 17.5 17 5 abnormal epidermal lamellar body morphology 0.026762092060162 0.115976836236329 0.952914280435987 0.875 17.5 17 5 abnormal meiotic spindle morphology 0.026762092060162 0.115976836236329 0.952914280435987 0.875 17.5 17 5 abnormal hepatic vein morphology 0.026762092060162 0.115976836236329 0.952914280435987 0.875 17.5 17 5 decreased alveolar lamellar body number 0.026762092060162 0.115976836236329 0.952914280435987 0.875 17.5 17 5 abnormal foramen magnum morphology 0.026762092060162 0.115976836236329 0.952914280435987 0.875 17.5 17 5 lethality during fetal growth through weaning, incomplete penetrance 0.026762092060162 0.115976836236329 0.952914280435987 0.875 17.5 17 5 decreased cranium length 0.026762092060162 0.115976836236329 0.952914280435987 0.875 17.5 17 5 increased cardiac stroke volume 0.026762092060162 0.115976836236329 0.952914280435987 0.875 17.5 17 5 prolonged PQ interval 0.026762092060162 0.115976836236329 0.952914280435987 0.875 17.5 17 5 increased circulating lactate level 0.026762092060162 0.115976836236329 0.952914280435987 0.875 17.5 17 5 absent hypoglossal canal 0.026762092060162 0.115976836236329 0.952914280435987 0.875 17.5 17 5 retropleural edema 0.026762092060162 0.115976836236329 0.952914280435987 0.875 17.5 17 5 abnormal umbilical vein topology 0.026762092060162 0.115976836236329 0.952914280435987 0.875 17.5 17 5 decreased basal metabolism 0.026762092060162 0.115976836236329 0.952914280435987 0.875 17.5 17 5 decreased vascular endothelial cell proliferation 0.026762092060162 0.115976836236329 0.952914280435987 0.875 17.5 17 5 abnormal cellular extravasation 6.18870655052531e-05 0.000777495330526854 0.952914280435987 0.875 17.5 17 5 abnormal T-helper 2 physiology 1.04052781313368e-09 3.54563415776715e-08 0.950439178408881 0.872727272727273 17.5 17 5 decreased circulating total protein level 1.04052781313368e-09 3.54563415776715e-08 0.950439178408881 0.872727272727273 17.5 17 5 small liver 3.55925185353943e-13 2.03531930705272e-11 0.949423751936222 0.871794871794872 17.5 17 5 abnormal definitive hematopoiesis 2.17239643850784e-15 1.7717495543568e-13 0.948522970387895 0.870967741935484 17.5 17 5 inner cell mass degeneration 6.06095284835604e-06 9.98451669555342e-05 0.948522970387895 0.870967741935484 17.5 17 5 neurodegeneration 1.90520563208923e-09 6.03719619085601e-08 0.947872405936326 0.87037037037037 17.5 17 5 decreased platelet aggregation 1.90520563208923e-09 6.03719619085601e-08 0.947872405936326 0.87037037037037 17.5 17 5 failure to gastrulate 3.38057151610945e-08 9.14040396339377e-07 0.946995558197255 0.869565217391304 17.5 17 5 abnormal neural tube closure 1.24994135730615e-13 7.97238237512577e-12 0.94471364118955 0.867469879518072 17.5 17 5 increased metastatic potential 1.10923726099419e-05 0.000173536332498306 0.943838906336597 0.866666666666667 17.5 17 5 arrested T cell differentiation 1.10923726099419e-05 0.000173536332498306 0.943838906336597 0.866666666666667 17.5 17 5 decreased thymocyte apoptosis 0.00224831896839982 0.0159109343780784 0.943838906336597 0.866666666666667 17.5 17 5 abnormal microglial cell activation 0.00224831896839982 0.0159109343780784 0.943838906336597 0.866666666666667 17.5 17 5 increased T cell number 4.34964707589527e-14 3.00548530591375e-12 0.940538770300455 0.863636363636364 17.5 17 5 abnormal myelopoiesis 1.12255741691774e-07 2.58551997646563e-06 0.940538770300455 0.863636363636364 17.5 17 5 abnormal mesenteric lymph node morphology 0.00020837965724431 0.00221514699741548 0.940538770300455 0.863636363636364 17.5 17 5 embryonic lethality before implantation, incomplete penetrance 0.00020837965724431 0.00221514699741548 0.940538770300455 0.863636363636364 17.5 17 5 decreased granulocyte number 2.02077635814873e-05 0.000292249272444358 0.938831803385209 0.862068965517241 17.5 17 5 abnormal CD8-positive, alpha-beta T cell physiology 2.02077635814873e-05 0.000292249272444358 0.938831803385209 0.862068965517241 17.5 17 5 hydrops fetalis 1.29230267976939e-11 5.84473257441157e-10 0.937788656937003 0.861111111111111 17.5 17 5 lethality throughout fetal growth and development, incomplete penetrance 9.3735612261341e-27 2.74314512353042e-24 0.936943650037619 0.860335195530726 17.5 17 5 decreased cell proliferation 1.80011609125022e-27 5.59723597123115e-25 0.93598993414253 0.859459459459459 17.5 17 5 decreased B cell number 2.15902948512385e-30 8.26243976037782e-28 0.93573274694685 0.859223300970874 17.5 17 5 increased T cell derived lymphoma incidence 3.76269788418794e-08 1.00642053622769e-06 0.933467050223008 0.857142857142857 17.5 17 5 abnormal midbrain development 3.63906492243172e-06 6.24287861693028e-05 0.933467050223008 0.857142857142857 17.5 17 5 abnormal humoral immune response 5.45378407057465e-16 4.93319559111071e-14 0.933467050223008 0.857142857142857 17.5 17 5 abnormal spleen white pulp morphology 3.67828395438341e-07 7.78700539279041e-06 0.933467050223008 0.857142857142857 17.5 17 5 abnormal brainstem morphology 3.66339216184539e-05 0.000484717446946298 0.933467050223008 0.857142857142857 17.5 17 5 abnormal mitotic spindle morphology 3.66339216184539e-05 0.000484717446946298 0.933467050223008 0.857142857142857 17.5 17 5 absent segment of posterior cerebral artery 0.000378949013462402 0.00363951996520357 0.933467050223008 0.857142857142857 17.5 17 5 abnormal antigen presentation 0.00411241103319882 0.0264331329330286 0.933467050223008 0.857142857142857 17.5 17 5 abnormal ventral body wall morphology 0.00411241103319882 0.0264331329330286 0.933467050223008 0.857142857142857 17.5 17 5 failure of zygotic cell division 0.00411241103319882 0.0264331329330286 0.933467050223008 0.857142857142857 17.5 17 5 abnormal vascular endothelial cell migration 0.00411241103319882 0.0264331329330286 0.933467050223008 0.857142857142857 17.5 17 5 split sternum 0.00411241103319882 0.0264331329330286 0.933467050223008 0.857142857142857 17.5 17 5 spina bifida occulta 0.00411241103319882 0.0264331329330286 0.933467050223008 0.857142857142857 17.5 17 5 multiple persisting craniopharyngeal ducts 0.00411241103319882 0.0264331329330286 0.933467050223008 0.857142857142857 17.5 17 5 abnormal vitelline vein topology 0.00411241103319882 0.0264331329330286 0.933467050223008 0.857142857142857 17.5 17 5 cellular necrosis 0.0496465243396589 0.186414718074837 0.933467050223008 0.857142857142857 17.5 17 5 polyphalangy 0.0496465243396589 0.186414718074837 0.933467050223008 0.857142857142857 17.5 17 5 abnormal lacrimal gland morphology 0.0496465243396589 0.186414718074837 0.933467050223008 0.857142857142857 17.5 17 5 abnormal circulating alanine transaminase level 0.0496465243396589 0.186414718074837 0.933467050223008 0.857142857142857 17.5 17 5 abnormal gastrulation movements 0.0496465243396589 0.186414718074837 0.933467050223008 0.857142857142857 17.5 17 5 detached tectorial membrane 0.0496465243396589 0.186414718074837 0.933467050223008 0.857142857142857 17.5 17 5 decreased cardiomyocyte apoptosis 0.0496465243396589 0.186414718074837 0.933467050223008 0.857142857142857 17.5 17 5 abnormal sinus venosus morphology 0.0496465243396589 0.186414718074837 0.933467050223008 0.857142857142857 17.5 17 5 aorta coarctation 0.0496465243396589 0.186414718074837 0.933467050223008 0.857142857142857 17.5 17 5 abnormal optic tract morphology 0.0496465243396589 0.186414718074837 0.933467050223008 0.857142857142857 17.5 17 5 abnormal cochlear nerve compound action potential 0.0496465243396589 0.186414718074837 0.933467050223008 0.857142857142857 17.5 17 5 abnormal MHC II cell surface expression on macrophages 0.0496465243396589 0.186414718074837 0.933467050223008 0.857142857142857 17.5 17 5 atherosclerotic lesions 0.0496465243396589 0.186414718074837 0.933467050223008 0.857142857142857 17.5 17 5 increased chronic myelocytic leukemia incidence 0.0496465243396589 0.186414718074837 0.933467050223008 0.857142857142857 17.5 17 5 abnormal renal filtration rate 0.0496465243396589 0.186414718074837 0.933467050223008 0.857142857142857 17.5 17 5 decreased tidal volume 0.0496465243396589 0.186414718074837 0.933467050223008 0.857142857142857 17.5 17 5 absent popliteal lymph nodes 0.0496465243396589 0.186414718074837 0.933467050223008 0.857142857142857 17.5 17 5 abnormal spinal cord central canal morphology 0.0496465243396589 0.186414718074837 0.933467050223008 0.857142857142857 17.5 17 5 postaxial polydactyly 0.0496465243396589 0.186414718074837 0.933467050223008 0.857142857142857 17.5 17 5 abnormal sperm annulus morphology 0.0496465243396589 0.186414718074837 0.933467050223008 0.857142857142857 17.5 17 5 increased DN3 thymocyte number 0.0496465243396589 0.186414718074837 0.933467050223008 0.857142857142857 17.5 17 5 decreased DN4 thymocyte number 0.0496465243396589 0.186414718074837 0.933467050223008 0.857142857142857 17.5 17 5 arteritis 0.0496465243396589 0.186414718074837 0.933467050223008 0.857142857142857 17.5 17 5 abnormal T wave 0.0496465243396589 0.186414718074837 0.933467050223008 0.857142857142857 17.5 17 5 abnormal aortic valve cusp morphology 0.0496465243396589 0.186414718074837 0.933467050223008 0.857142857142857 17.5 17 5 altered tumor pathology 0.0496465243396589 0.186414718074837 0.933467050223008 0.857142857142857 17.5 17 5 increased compact bone volume 0.0496465243396589 0.186414718074837 0.933467050223008 0.857142857142857 17.5 17 5 embryonic lethality at implantation, incomplete penetrance 0.0496465243396589 0.186414718074837 0.933467050223008 0.857142857142857 17.5 17 5 parturition failure 0.0496465243396589 0.186414718074837 0.933467050223008 0.857142857142857 17.5 17 5 decreased areal bone mineral density 0.0496465243396589 0.186414718074837 0.933467050223008 0.857142857142857 17.5 17 5 abnormal Mullerian duct topology 0.0496465243396589 0.186414718074837 0.933467050223008 0.857142857142857 17.5 17 5 absent connection between subcutaneous lymph vessels and lymph sac 0.0496465243396589 0.186414718074837 0.933467050223008 0.857142857142857 17.5 17 5 abnormal hepatocyte morphology 1.03864191363726e-16 1.03344870406907e-14 0.932065448045496 0.855855855855856 17.5 17 5 small heart 6.7715515604351e-08 1.71007456919617e-06 0.930225845187512 0.854166666666667 17.5 17 5 abnormal spleen red pulp morphology 6.55604971578992e-06 0.000107644710680049 0.928891231349366 0.852941176470588 17.5 17 5 decreased embryo size 7.54660051373586e-66 7.50886751116719e-63 0.927282993753609 0.851464435146444 17.5 17 5 abnormal T-helper 1 physiology 1.21461696086152e-07 2.77188962398444e-06 0.926846716533483 0.851063829787234 17.5 17 5 abnormal cytokine secretion 5.25345829299536e-22 1.00522903875584e-19 0.926395330145561 0.850649350649351 17.5 17 5 abnormal circulating enzyme level 0.00068450299925922 0.005912156981449 0.925688158137816 0.85 17.5 17 5 abnormal Peyer's patch T cell area morphology 0.00068450299925922 0.005912156981449 0.925688158137816 0.85 17.5 17 5 abnormal sperm mitochondrial sheath morphology 0.00068450299925922 0.005912156981449 0.925688158137816 0.85 17.5 17 5 abnormal embryo size 2.02807516462166e-16 1.90371206490429e-14 0.925206279867052 0.849557522123894 17.5 17 5 decreased bone marrow cell number 4.55315892001379e-11 1.88766380225572e-09 0.924942236978962 0.849315068493151 17.5 17 5 embryonic lethality between implantation and somite formation, complete penetrance 7.32037772038874e-34 3.6418879158934e-31 0.924576887839932 0.848979591836735 17.5 17 5 thrombocytopenia 1.5700224375853e-20 2.29731224323143e-18 0.923810494531046 0.848275862068966 17.5 17 5 abnormal cell death 2.17114932554867e-07 4.77941057283391e-06 0.923320669242323 0.847826086956522 17.5 17 5 lethality throughout fetal growth and development, complete penetrance 2.48115625021543e-26 6.85764019156764e-24 0.922822250527483 0.847368421052632 17.5 17 5 increased tumor incidence 1.29712941279352e-17 1.43404862858839e-15 0.922175110099343 0.846774193548387 17.5 17 5 abnormal leukocyte migration 3.99559429257536e-08 1.05734476625332e-06 0.921499523938098 0.846153846153846 17.5 17 5 kinked neural tube 3.99559429257536e-08 1.05734476625332e-06 0.921499523938098 0.846153846153846 17.5 17 5 abnormal leukocyte cell number 0.000118466275644155 0.00137062725890621 0.921499523938098 0.846153846153846 17.5 17 5 abnormal erythrocyte osmotic lysis 0.000118466275644155 0.00137062725890621 0.921499523938098 0.846153846153846 17.5 17 5 absent common myeloid progenitor cells 0.00745115686495355 0.0434118315214952 0.921499523938098 0.846153846153846 17.5 17 5 increased foot pad pigmentation 0.00745115686495355 0.0434118315214952 0.921499523938098 0.846153846153846 17.5 17 5 lymphoid hypoplasia 0.00745115686495355 0.0434118315214952 0.921499523938098 0.846153846153846 17.5 17 5 abnormal exocrine pancreas morphology 0.00745115686495355 0.0434118315214952 0.921499523938098 0.846153846153846 17.5 17 5 increased grip strength 3.02302507850006e-13 1.76935879594562e-11 0.921499523938098 0.846153846153846 17.5 17 5 increased embryonic tissue cell apoptosis 1.52065751283359e-11 6.81555957328567e-10 0.921499523938098 0.846153846153846 17.5 17 5 increased autoantibody level 2.121700306259e-06 3.82451504526337e-05 0.921499523938098 0.846153846153846 17.5 17 5 preweaning lethality, complete penetrance 2.00836023867852e-98 9.99159218742565e-95 0.921273111278654 0.845945945945946 17.5 17 5 decreased T cell number 3.39349168801323e-22 7.03442547827742e-20 0.919938542248762 0.84472049689441 17.5 17 5 abnormal osteoclast physiology 1.37319477334793e-09 4.55442933160398e-08 0.918881627563274 0.84375 17.5 17 5 increased lung adenocarcinoma incidence 7.10040183740569e-08 1.7686447474354e-06 0.918214320644201 0.843137254901961 17.5 17 5 decreased total retina thickness 3.77394396282139e-06 6.42992164898507e-05 0.917090435306815 0.842105263157895 17.5 17 5 increased susceptibility to ischemic brain injury 0.00122728651551928 0.0098479845398523 0.917090435306815 0.842105263157895 17.5 17 5 abnormal dendritic cell physiology 6.35551044383195e-15 4.64980359677411e-13 0.916019067975849 0.841121495327103 17.5 17 5 microcephaly 4.52859788626814e-10 1.66887218401363e-08 0.915429039590679 0.840579710144927 17.5 17 5 ruffled hair 0.000211143891546265 0.00221611995873981 0.914797709218548 0.84 17.5 17 5 abnormal thyroid gland morphology 0.000211143891546265 0.00221611995873981 0.914797709218548 0.84 17.5 17 5 spontaneous skin ulceration 0.000211143891546265 0.00221611995873981 0.914797709218548 0.84 17.5 17 5 abnormal primitive streak morphology 0.000211143891546265 0.00221611995873981 0.914797709218548 0.84 17.5 17 5 abnormal object recognition memory 3.72557553701887e-05 0.000489043226825036 0.913392490003158 0.838709677419355 17.5 17 5 abnormal CD8-positive, alpha beta T cell morphology 3.72557553701887e-05 0.000489043226825036 0.913392490003158 0.838709677419355 17.5 17 5 abnormal mitochondrial ATP synthesis coupled electron transport 3.72557553701887e-05 0.000489043226825036 0.913392490003158 0.838709677419355 17.5 17 5 abnormal chromosome morphology 6.68286112114603e-06 0.000109365901571387 0.912443017560328 0.837837837837838 17.5 17 5 embryonic lethality, complete penetrance 9.76658784061639e-41 6.94125350100951e-38 0.911520332741276 0.836990595611285 17.5 17 5 decreased circulating creatinine level 2.21919266512019e-07 4.84231732849691e-06 0.911241644265318 0.836734693877551 17.5 17 5 abnormal embryo turning 4.08745671864894e-08 1.06466477357479e-06 0.910837545975178 0.836363636363636 17.5 17 5 abnormal platelet physiology 4.08745671864894e-08 1.06466477357479e-06 0.910837545975178 0.836363636363636 17.5 17 5 embryonic growth arrest 3.9659334867263e-29 1.40932279260452e-26 0.908330019030686 0.834061135371179 17.5 17 5 thymus hypoplasia 4.84719951457599e-18 5.60809711279432e-16 0.907537409939036 0.833333333333333 17.5 17 5 absent mesoderm 1.32856394165429e-08 3.86526643843864e-07 0.907537409939036 0.833333333333333 17.5 17 5 decreased tumor growth/size 7.18123093431057e-08 1.7686447474354e-06 0.907537409939036 0.833333333333333 17.5 17 5 abnormal cell adhesion 7.18123093431057e-08 1.7686447474354e-06 0.907537409939036 0.833333333333333 17.5 17 5 abnormal lymph node morphology 3.9019259849516e-07 8.22545837929415e-06 0.907537409939036 0.833333333333333 17.5 17 5 salivary gland inflammation 6.57847184392131e-05 0.000810096470878924 0.907537409939036 0.833333333333333 17.5 17 5 liver hemorrhage 6.57847184392131e-05 0.000810096470878924 0.907537409939036 0.833333333333333 17.5 17 5 abnormal brain vasculature morphology 6.57847184392131e-05 0.000810096470878924 0.907537409939036 0.833333333333333 17.5 17 5 abnormal mitral valve morphology 0.00218249647704723 0.0155335049689699 0.907537409939036 0.833333333333333 17.5 17 5 abnormal thymus medulla morphology 0.00218249647704723 0.0155335049689699 0.907537409939036 0.833333333333333 17.5 17 5 abnormal redox activity 0.00218249647704723 0.0155335049689699 0.907537409939036 0.833333333333333 17.5 17 5 abnormal eye anterior chamber morphology 0.00218249647704723 0.0155335049689699 0.907537409939036 0.833333333333333 17.5 17 5 abnormal pregnancy 0.00218249647704723 0.0155335049689699 0.907537409939036 0.833333333333333 17.5 17 5 increased gastrointestinal tumor incidence 0.00218249647704723 0.0155335049689699 0.907537409939036 0.833333333333333 17.5 17 5 primary atelectasis 0.00218249647704723 0.0155335049689699 0.907537409939036 0.833333333333333 17.5 17 5 increased effector memory CD8-positive, alpha-beta T cell number 0.00218249647704723 0.0155335049689699 0.907537409939036 0.833333333333333 17.5 17 5 abnormal aerobic respiration 0.00218249647704723 0.0155335049689699 0.907537409939036 0.833333333333333 17.5 17 5 impaired embryo implantation 0.0133542757305502 0.069205751832799 0.907537409939036 0.833333333333333 17.5 17 5 interstitial pneumonia 0.0133542757305502 0.069205751832799 0.907537409939036 0.833333333333333 17.5 17 5 altered tumor susceptibility 0.0133542757305502 0.069205751832799 0.907537409939036 0.833333333333333 17.5 17 5 increased growth rate 0.0133542757305502 0.069205751832799 0.907537409939036 0.833333333333333 17.5 17 5 small intestinal inflammation 0.0133542757305502 0.069205751832799 0.907537409939036 0.833333333333333 17.5 17 5 abnormal defecation 0.0133542757305502 0.069205751832799 0.907537409939036 0.833333333333333 17.5 17 5 embryonic lethality between implantation and placentation, incomplete penetrance 0.0133542757305502 0.069205751832799 0.907537409939036 0.833333333333333 17.5 17 5 large anterior fontanelle 0.090627778301733 0.280393779260648 0.907537409939036 0.833333333333333 17.5 17 5 echinocytosis 0.090627778301733 0.280393779260648 0.907537409939036 0.833333333333333 17.5 17 5 poor arterial differentiation 0.090627778301733 0.280393779260648 0.907537409939036 0.833333333333333 17.5 17 5 hemoglobinuria 0.090627778301733 0.280393779260648 0.907537409939036 0.833333333333333 17.5 17 5 thin tail 0.090627778301733 0.280393779260648 0.907537409939036 0.833333333333333 17.5 17 5 epidermal necrosis 0.090627778301733 0.280393779260648 0.907537409939036 0.833333333333333 17.5 17 5 abnormal lens induction 0.090627778301733 0.280393779260648 0.907537409939036 0.833333333333333 17.5 17 5 abnormal lacrimal gland physiology 0.090627778301733 0.280393779260648 0.907537409939036 0.833333333333333 17.5 17 5 absent ectoplacental cone 0.090627778301733 0.280393779260648 0.907537409939036 0.833333333333333 17.5 17 5 abnormal lymph organ size 0.090627778301733 0.280393779260648 0.907537409939036 0.833333333333333 17.5 17 5 abnormal blood gas level 0.090627778301733 0.280393779260648 0.907537409939036 0.833333333333333 17.5 17 5 abnormal cervical lymph node morphology 0.090627778301733 0.280393779260648 0.907537409939036 0.833333333333333 17.5 17 5 chromatolysis 0.090627778301733 0.280393779260648 0.907537409939036 0.833333333333333 17.5 17 5 increased post-tetanic potentiation 0.090627778301733 0.280393779260648 0.907537409939036 0.833333333333333 17.5 17 5 abnormal hippocampal fimbria morphology 0.090627778301733 0.280393779260648 0.907537409939036 0.833333333333333 17.5 17 5 liver cirrhosis 0.090627778301733 0.280393779260648 0.907537409939036 0.833333333333333 17.5 17 5 decreased posterior semicircular canal size 0.090627778301733 0.280393779260648 0.907537409939036 0.833333333333333 17.5 17 5 extremity edema 0.090627778301733 0.280393779260648 0.907537409939036 0.833333333333333 17.5 17 5 bile duct inflammation 0.090627778301733 0.280393779260648 0.907537409939036 0.833333333333333 17.5 17 5 abnormal intestinal peristalsis 0.090627778301733 0.280393779260648 0.907537409939036 0.833333333333333 17.5 17 5 decreased liver function 0.090627778301733 0.280393779260648 0.907537409939036 0.833333333333333 17.5 17 5 enlarged pancreas 0.090627778301733 0.280393779260648 0.907537409939036 0.833333333333333 17.5 17 5 rheumatoid arthritis 0.090627778301733 0.280393779260648 0.907537409939036 0.833333333333333 17.5 17 5 shortened QT interval 0.090627778301733 0.280393779260648 0.907537409939036 0.833333333333333 17.5 17 5 abnormal cholesterol level 0.090627778301733 0.280393779260648 0.907537409939036 0.833333333333333 17.5 17 5 vestibular saccular degeneration 0.090627778301733 0.280393779260648 0.907537409939036 0.833333333333333 17.5 17 5 bowed humerus 0.090627778301733 0.280393779260648 0.907537409939036 0.833333333333333 17.5 17 5 abnormal common crus morphology 0.090627778301733 0.280393779260648 0.907537409939036 0.833333333333333 17.5 17 5 decreased prostate gland weight 0.090627778301733 0.280393779260648 0.907537409939036 0.833333333333333 17.5 17 5 abnormal blastocoele morphology 0.090627778301733 0.280393779260648 0.907537409939036 0.833333333333333 17.5 17 5 osteomyelitis 0.090627778301733 0.280393779260648 0.907537409939036 0.833333333333333 17.5 17 5 abnormal heart size 0.090627778301733 0.280393779260648 0.907537409939036 0.833333333333333 17.5 17 5 decreased platelet ADP level 0.090627778301733 0.280393779260648 0.907537409939036 0.833333333333333 17.5 17 5 absent brachial lymph nodes 0.090627778301733 0.280393779260648 0.907537409939036 0.833333333333333 17.5 17 5 delayed chorioallantoic fusion 0.090627778301733 0.280393779260648 0.907537409939036 0.833333333333333 17.5 17 5 absent sperm mitochondrial sheath 0.090627778301733 0.280393779260648 0.907537409939036 0.833333333333333 17.5 17 5 abnormal neural crest cell morphology 0.090627778301733 0.280393779260648 0.907537409939036 0.833333333333333 17.5 17 5 visceral vascular congestion 0.090627778301733 0.280393779260648 0.907537409939036 0.833333333333333 17.5 17 5 abnormal orbit morphology 0.090627778301733 0.280393779260648 0.907537409939036 0.833333333333333 17.5 17 5 abnormal oval cell physiology 0.090627778301733 0.280393779260648 0.907537409939036 0.833333333333333 17.5 17 5 decreased DN1 thymic pro-T cell number 0.090627778301733 0.280393779260648 0.907537409939036 0.833333333333333 17.5 17 5 myocardium hypoplasia 0.090627778301733 0.280393779260648 0.907537409939036 0.833333333333333 17.5 17 5 common truncal valve 0.090627778301733 0.280393779260648 0.907537409939036 0.833333333333333 17.5 17 5 thick pulmonary valve cusps 0.090627778301733 0.280393779260648 0.907537409939036 0.833333333333333 17.5 17 5 absent third pharyngeal arch 0.090627778301733 0.280393779260648 0.907537409939036 0.833333333333333 17.5 17 5 persistent hyperplastic primary vitreous 0.090627778301733 0.280393779260648 0.907537409939036 0.833333333333333 17.5 17 5 abnormal intestinal enteroendocrine cell morphology 0.090627778301733 0.280393779260648 0.907537409939036 0.833333333333333 17.5 17 5 decreased compact bone mass 0.090627778301733 0.280393779260648 0.907537409939036 0.833333333333333 17.5 17 5 abnormal ureteric bud tip morphology 0.090627778301733 0.280393779260648 0.907537409939036 0.833333333333333 17.5 17 5 abnormal endocrine pancreas development 0.090627778301733 0.280393779260648 0.907537409939036 0.833333333333333 17.5 17 5 increased bone trabecular spacing 0.090627778301733 0.280393779260648 0.907537409939036 0.833333333333333 17.5 17 5 absent thymus corticomedullary boundary 0.090627778301733 0.280393779260648 0.907537409939036 0.833333333333333 17.5 17 5 increased effector memory T-helper cell number 0.090627778301733 0.280393779260648 0.907537409939036 0.833333333333333 17.5 17 5 additional anastomosis between intracranial vertebral arteries 0.090627778301733 0.280393779260648 0.907537409939036 0.833333333333333 17.5 17 5 abnormal Wolffian duct connection 0.090627778301733 0.280393779260648 0.907537409939036 0.833333333333333 17.5 17 5 abnormal platelet alpha-granule morphology 0.090627778301733 0.280393779260648 0.907537409939036 0.833333333333333 17.5 17 5 ectopic bone 0.090627778301733 0.280393779260648 0.907537409939036 0.833333333333333 17.5 17 5 decreased capillary density 0.090627778301733 0.280393779260648 0.907537409939036 0.833333333333333 17.5 17 5 decreased retinal apoptosis 0.090627778301733 0.280393779260648 0.907537409939036 0.833333333333333 17.5 17 5 abnormal cell nucleus morphology 6.83424460339849e-07 1.3821287358499e-05 0.903675548620146 0.829787234042553 17.5 17 5 thick ventricular wall 3.74024223729058e-06 6.39440038849506e-05 0.903110398183236 0.829268292682927 17.5 17 5 embryonic lethality during organogenesis, complete penetrance 3.54530534934958e-67 4.40947352825354e-64 0.902351481882241 0.828571428571429 17.5 17 5 pallor 6.85170069066145e-22 1.26248929392743e-19 0.902351481882241 0.828571428571429 17.5 17 5 increased carcinoma incidence 2.06548095503546e-05 0.000296987507263047 0.902351481882241 0.828571428571429 17.5 17 5 abnormal hippocampus pyramidal cell morphology 2.06548095503546e-05 0.000296987507263047 0.902351481882241 0.828571428571429 17.5 17 5 abnormal spleen morphology 1.19231768853057e-21 2.04544155187571e-19 0.901278531249801 0.827586206896552 17.5 17 5 abnormal embryonic neuroepithelium morphology 4.05704618767755e-08 1.06466477357479e-06 0.901278531249801 0.827586206896552 17.5 17 5 lordosis 0.000115479480195895 0.00134861599524549 0.901278531249801 0.827586206896552 17.5 17 5 abnormal embryonic erythropoiesis 0.000115479480195895 0.00134861599524549 0.901278531249801 0.827586206896552 17.5 17 5 blood in lymph vessels 0.000115479480195895 0.00134861599524549 0.901278531249801 0.827586206896552 17.5 17 5 abnormal placenta vasculature 2.19344823293726e-07 4.8072268541246e-06 0.900556352939505 0.826923076923077 17.5 17 5 embryonic lethality between implantation and placentation, complete penetrance 1.19221734489359e-06 2.28126203494063e-05 0.899645780287392 0.826086956521739 17.5 17 5 abnormal regulatory T cell physiology 0.000657244927720248 0.00570644592566882 0.899645780287392 0.826086956521739 17.5 17 5 abnormal hematopoietic stem cell physiology 0.000657244927720248 0.00570644592566882 0.899645780287392 0.826086956521739 17.5 17 5 abnormal vertebral artery topology 0.000657244927720248 0.00570644592566882 0.899645780287392 0.826086956521739 17.5 17 5 enlarged liver sinusoidal spaces 3.60302937965622e-05 0.000479279977641435 0.89686049923387 0.823529411764706 17.5 17 5 abnormal interatrial septum morphology 0.00384594531914106 0.025275532315359 0.89686049923387 0.823529411764706 17.5 17 5 abnormal dorsal-ventral axis patterning 0.00384594531914106 0.025275532315359 0.89686049923387 0.823529411764706 17.5 17 5 abnormal tarsal bone morphology 0.00384594531914106 0.025275532315359 0.89686049923387 0.823529411764706 17.5 17 5 pancytopenia 0.00384594531914106 0.025275532315359 0.89686049923387 0.823529411764706 17.5 17 5 increased trabecular bone mass 0.00384594531914106 0.025275532315359 0.89686049923387 0.823529411764706 17.5 17 5 abnormal ductus venosus valve morphology 0.00384594531914106 0.025275532315359 0.89686049923387 0.823529411764706 17.5 17 5 abnormal ectoderm development 2.07106971823268e-06 3.76042768182758e-05 0.895436911139848 0.822222222222222 17.5 17 5 abnormal myocardial trabeculae morphology 2.07106971823268e-06 3.76042768182758e-05 0.895436911139848 0.822222222222222 17.5 17 5 small superior cervical ganglion 0.000201443310712 0.00215522681890795 0.894572589797049 0.821428571428571 17.5 17 5 abnormal leukocyte adhesion 1.13270578213924e-05 0.00017610035206696 0.893575295939973 0.82051282051282 17.5 17 5 impaired macrophage chemotaxis 1.13270578213924e-05 0.00017610035206696 0.893575295939973 0.82051282051282 17.5 17 5 enlarged spleen 3.02729453199264e-33 1.36916275424213e-30 0.892411786440052 0.819444444444444 17.5 17 5 abnormal vascular development 1.26484071244806e-08 3.70151914378183e-07 0.891036729758326 0.818181818181818 17.5 17 5 increased cardiomyocyte apoptosis 6.24996202775116e-05 0.000781245253468895 0.891036729758326 0.818181818181818 17.5 17 5 abnormal locomotor coordination 6.24996202775116e-05 0.000781245253468895 0.891036729758326 0.818181818181818 17.5 17 5 osteoporosis 3.58198561663987e-06 6.16622091445791e-05 0.891036729758326 0.818181818181818 17.5 17 5 abnormal enterocyte morphology 0.00114651111644381 0.00927462244602923 0.891036729758326 0.818181818181818 17.5 17 5 intestinal inflammation 0.00114651111644381 0.00927462244602923 0.891036729758326 0.818181818181818 17.5 17 5 abnormal vascular branching morphogenesis 0.00114651111644381 0.00927462244602923 0.891036729758326 0.818181818181818 17.5 17 5 increased mammary gland tumor incidence 0.00114651111644381 0.00927462244602923 0.891036729758326 0.818181818181818 17.5 17 5 increased adenoma incidence 0.00114651111644381 0.00927462244602923 0.891036729758326 0.818181818181818 17.5 17 5 abnormal sphenoid bone morphology 0.0236329041434743 0.111338729274417 0.891036729758326 0.818181818181818 17.5 17 5 abnormal eye distance/ position 0.0236329041434743 0.111338729274417 0.891036729758326 0.818181818181818 17.5 17 5 impaired myelopoiesis 0.0236329041434743 0.111338729274417 0.891036729758326 0.818181818181818 17.5 17 5 failure of somite differentiation 0.0236329041434743 0.111338729274417 0.891036729758326 0.818181818181818 17.5 17 5 abnormal proximal-distal axis patterning 0.0236329041434743 0.111338729274417 0.891036729758326 0.818181818181818 17.5 17 5 dilated renal glomerular capsule 0.0236329041434743 0.111338729274417 0.891036729758326 0.818181818181818 17.5 17 5 pharyngeal arch hypoplasia 0.0236329041434743 0.111338729274417 0.891036729758326 0.818181818181818 17.5 17 5 abnormal dorsal-ventral polarity of the somites 0.0236329041434743 0.111338729274417 0.891036729758326 0.818181818181818 17.5 17 5 increased glycogen level 0.0236329041434743 0.111338729274417 0.891036729758326 0.818181818181818 17.5 17 5 abnormal palate development 0.0236329041434743 0.111338729274417 0.891036729758326 0.818181818181818 17.5 17 5 aberrant origin of the right subclavian artery 0.0236329041434743 0.111338729274417 0.891036729758326 0.818181818181818 17.5 17 5 increased sarcoma incidence 1.13807407397577e-06 2.20308113542002e-05 0.889016238307627 0.816326530612245 17.5 17 5 embryonic lethality before implantation, complete penetrance 6.17526971950944e-15 4.58536818724768e-13 0.888660631812304 0.816 17.5 17 5 decreased hair follicle number 1.95652085365834e-05 0.00028544549111291 0.888431359203477 0.815789473684211 17.5 17 5 incomplete somite formation 1.95652085365834e-05 0.00028544549111291 0.888431359203477 0.815789473684211 17.5 17 5 decreased neuron apoptosis 1.95652085365834e-05 0.00028544549111291 0.888431359203477 0.815789473684211 17.5 17 5 decreased erythrocyte cell number 2.55109096942808e-18 3.02182799354874e-16 0.887883733545452 0.815286624203822 17.5 17 5 increased brain weight 0.000349035541926594 0.00340239618952844 0.88736991194039 0.814814814814815 17.5 17 5 abnormal eye muscle morphology 0.000349035541926594 0.00340239618952844 0.88736991194039 0.814814814814815 17.5 17 5 increased spleen weight 1.70546579663727e-13 1.03471857783786e-11 0.886656018205925 0.814159292035398 17.5 17 5 decreased lymphocyte cell number 5.89577792891965e-15 4.44416593884474e-13 0.88484897469056 0.8125 17.5 17 5 decreased caudal vertebrae number 3.72543245516348e-08 1.00183926834802e-06 0.88484897469056 0.8125 17.5 17 5 decreased mast cell number 0.00670858349042844 0.0394972814969012 0.88484897469056 0.8125 17.5 17 5 abnormal hair follicle orientation 0.00670858349042844 0.0394972814969012 0.88484897469056 0.8125 17.5 17 5 mixed cellular infiltration to dermis 0.00670858349042844 0.0394972814969012 0.88484897469056 0.8125 17.5 17 5 increased intestinal adenocarcinoma incidence 0.00670858349042844 0.0394972814969012 0.88484897469056 0.8125 17.5 17 5 impaired muscle relaxation 0.00670858349042844 0.0394972814969012 0.88484897469056 0.8125 17.5 17 5 increased thymus weight 0.00670858349042844 0.0394972814969012 0.88484897469056 0.8125 17.5 17 5 kidney degeneration 0.00670858349042844 0.0394972814969012 0.88484897469056 0.8125 17.5 17 5 impaired somite development 0.00670858349042844 0.0394972814969012 0.88484897469056 0.8125 17.5 17 5 decreased fibroblast apoptosis 0.00670858349042844 0.0394972814969012 0.88484897469056 0.8125 17.5 17 5 thymus atrophy 1.95409586166684e-06 3.61398769955113e-05 0.88484897469056 0.8125 17.5 17 5 abnormal mesoderm development 6.21883048150608e-07 1.26797875596282e-05 0.883564723638759 0.811320754716981 17.5 17 5 oxidative stress 7.63850215375078e-11 3.08955676543985e-09 0.883336412340661 0.811111111111111 17.5 17 5 anemia 1.96630943639925e-23 4.65828068861251e-21 0.882590883978626 0.81042654028436 17.5 17 5 abnormal embryonic tissue morphology 1.13424310503711e-16 1.10644302893326e-14 0.881607769655063 0.80952380952381 17.5 17 5 spleen hypoplasia 2.60680292425985e-12 1.28404401467255e-10 0.881607769655063 0.80952380952381 17.5 17 5 abnormal hematopoietic system physiology 0.0019831074388957 0.01478991175956 0.881607769655063 0.80952380952381 17.5 17 5 abnormal tumor vascularization 0.0019831074388957 0.01478991175956 0.881607769655063 0.80952380952381 17.5 17 5 increased muscle cell glucose uptake 0.0019831074388957 0.01478991175956 0.881607769655063 0.80952380952381 17.5 17 5 decreased rib number 1.30119621187853e-10 4.94156576648528e-09 0.881025081109356 0.808988764044944 17.5 17 5 abnormal embryo development 1.81636407043523e-15 1.50606854173587e-13 0.880845133176123 0.808823529411765 17.5 17 5 pericardial edema 2.04265163821036e-08 5.7739726705094e-07 0.880845133176123 0.808823529411765 17.5 17 5 decreased circulating alanine transaminase level 2.04265163821036e-08 5.7739726705094e-07 0.880845133176123 0.808823529411765 17.5 17 5 abnormal vitelline vasculature morphology 2.75215390612435e-13 1.64963441963478e-11 0.880705869123447 0.808695652173913 17.5 17 5 liver inflammation 8.94952294865085e-14 5.78232164539454e-12 0.880311287640865 0.808333333333333 17.5 17 5 distended pericardium 1.0611534762759e-06 2.07844037183961e-05 0.879613181940912 0.807692307692308 17.5 17 5 heart inflammation 0.000600389878335127 0.0054013375130511 0.879613181940912 0.807692307692308 17.5 17 5 decreased bone resorption 0.000600389878335127 0.0054013375130511 0.879613181940912 0.807692307692308 17.5 17 5 pale yolk sac 6.83938890956497e-10 2.44791077878315e-08 0.879108527218054 0.807228915662651 17.5 17 5 decreased brain weight 3.3838958193266e-07 7.25641452635769e-06 0.878878333835698 0.807017543859649 17.5 17 5 osteopetrosis 0.000184655397893481 0.0019970882706958 0.878262009618422 0.806451612903226 17.5 17 5 decreased double-negative T cell number 0.000184655397893481 0.0019970882706958 0.878262009618422 0.806451612903226 17.5 17 5 abnormal pharyngeal arch morphology 5.7429570551752e-05 0.000725157648464381 0.877286162941068 0.805555555555556 17.5 17 5 abnormal trophoblast giant cell morphology 5.7429570551752e-05 0.000725157648464381 0.877286162941068 0.805555555555556 17.5 17 5 abnormal developmental patterning 1.15978078150222e-09 3.89858742430645e-08 0.876548327648434 0.804878048780488 17.5 17 5 abnormal dendritic spine morphology 1.80307395736726e-06 3.35966027636784e-05 0.87550667782354 0.803921568627451 17.5 17 5 decreased leukocyte cell number 4.86678166196907e-15 3.72495981050709e-13 0.874415606656589 0.802919708029197 17.5 17 5 abnormal vascular regression 0.00339842058055954 0.0226031315351386 0.871235913541474 0.8 17.5 17 5 small gonad 0.00339842058055954 0.0226031315351386 0.871235913541474 0.8 17.5 17 5 increased mammary adenocarcinoma incidence 0.00339842058055954 0.0226031315351386 0.871235913541474 0.8 17.5 17 5 decreased myocardial infarction size 0.00339842058055954 0.0226031315351386 0.871235913541474 0.8 17.5 17 5 abnormal neuron proliferation 0.00339842058055954 0.0226031315351386 0.871235913541474 0.8 17.5 17 5 enlarged testis 0.0412042862255031 0.165315583848288 0.871235913541474 0.8 17.5 17 5 fused cornea and lens 0.0412042862255031 0.165315583848288 0.871235913541474 0.8 17.5 17 5 abnormal gland morphology 0.0412042862255031 0.165315583848288 0.871235913541474 0.8 17.5 17 5 increased natural killer cell mediated cytotoxicity 0.0412042862255031 0.165315583848288 0.871235913541474 0.8 17.5 17 5 aneurysm 0.0412042862255031 0.165315583848288 0.871235913541474 0.8 17.5 17 5 absent pharyngeal arches 0.0412042862255031 0.165315583848288 0.871235913541474 0.8 17.5 17 5 abnormal plasma membrane morphology 0.0412042862255031 0.165315583848288 0.871235913541474 0.8 17.5 17 5 abnormal embryonic erythrocyte morphology 0.0412042862255031 0.165315583848288 0.871235913541474 0.8 17.5 17 5 abnormal placental transport 0.0412042862255031 0.165315583848288 0.871235913541474 0.8 17.5 17 5 abnormal deltoid tuberosity morphology 0.0412042862255031 0.165315583848288 0.871235913541474 0.8 17.5 17 5 ascites 0.0412042862255031 0.165315583848288 0.871235913541474 0.8 17.5 17 5 increased susceptibility to atherosclerosis 0.0412042862255031 0.165315583848288 0.871235913541474 0.8 17.5 17 5 osteosclerosis 0.0412042862255031 0.165315583848288 0.871235913541474 0.8 17.5 17 5 tachypnea 0.0412042862255031 0.165315583848288 0.871235913541474 0.8 17.5 17 5 abnormal developmental vascular remodeling 0.0412042862255031 0.165315583848288 0.871235913541474 0.8 17.5 17 5 absent axillary lymph nodes 0.0412042862255031 0.165315583848288 0.871235913541474 0.8 17.5 17 5 abnormal hippocampus neuron morphology 0.0412042862255031 0.165315583848288 0.871235913541474 0.8 17.5 17 5 acanthocytosis 0.0412042862255031 0.165315583848288 0.871235913541474 0.8 17.5 17 5 abnormal vibrissa follicle morphology 0.0412042862255031 0.165315583848288 0.871235913541474 0.8 17.5 17 5 abnormal heart and great artery attachment 0.0412042862255031 0.165315583848288 0.871235913541474 0.8 17.5 17 5 common ventricle 0.0412042862255031 0.165315583848288 0.871235913541474 0.8 17.5 17 5 thin ventricle myocardium compact layer 0.0412042862255031 0.165315583848288 0.871235913541474 0.8 17.5 17 5 thick aortic valve 0.0412042862255031 0.165315583848288 0.871235913541474 0.8 17.5 17 5 decreased trabecular bone connectivity density 0.0412042862255031 0.165315583848288 0.871235913541474 0.8 17.5 17 5 decreased macrophage apoptosis 0.0412042862255031 0.165315583848288 0.871235913541474 0.8 17.5 17 5 decreased circulating lactate level 0.0412042862255031 0.165315583848288 0.871235913541474 0.8 17.5 17 5 increased monocyte cell number 3.61756124867665e-11 1.51238379934171e-09 0.871235913541474 0.8 17.5 17 5 increased inflammatory response 1.11669571293309e-10 4.34028216550165e-09 0.871235913541474 0.8 17.5 17 5 domed cranium 3.18836431130559e-08 8.71544640040951e-07 0.871235913541474 0.8 17.5 17 5 abnormal interventricular septum morphology 3.05027509263015e-06 5.32460301257367e-05 0.871235913541474 0.8 17.5 17 5 increased circulating serum albumin level 9.75322307813919e-05 0.00115254833286799 0.871235913541474 0.8 17.5 17 5 increased red blood cell distribution width 9.75322307813919e-05 0.00115254833286799 0.871235913541474 0.8 17.5 17 5 gastrointestinal hemorrhage 0.000314258527222621 0.00310205589867567 0.871235913541474 0.8 17.5 17 5 disorganized myocardium 0.000314258527222621 0.00310205589867567 0.871235913541474 0.8 17.5 17 5 abnormal egg cylinder morphology 0.00102469896313857 0.0085106466471025 0.871235913541474 0.8 17.5 17 5 decreased placenta weight 0.00102469896313857 0.0085106466471025 0.871235913541474 0.8 17.5 17 5 abnormal fontanelle morphology 0.0115687792923949 0.0632468977798513 0.871235913541474 0.8 17.5 17 5 macrocytosis 0.0115687792923949 0.0632468977798513 0.871235913541474 0.8 17.5 17 5 decreased salivation 0.0115687792923949 0.0632468977798513 0.871235913541474 0.8 17.5 17 5 abnormal lymph node B cell domain morphology 0.0115687792923949 0.0632468977798513 0.871235913541474 0.8 17.5 17 5 abnormal trophectoderm morphology 0.0115687792923949 0.0632468977798513 0.871235913541474 0.8 17.5 17 5 albuminuria 9.62564921026878e-06 0.000153749577981426 0.871235913541474 0.8 17.5 17 5 decreased circulating serum albumin level 6.0788762990617e-11 2.4788860317895e-09 0.869035822850713 0.797979797979798 17.5 17 5 increased mean corpuscular hemoglobin 6.0788762990617e-11 2.4788860317895e-09 0.869035822850713 0.797979797979798 17.5 17 5 increased granulocyte number 1.72485052594747e-08 4.98902986429573e-07 0.868292548968699 0.797297297297297 17.5 17 5 decreased spleen weight 5.3618664204351e-08 1.36098395110534e-06 0.868079261680817 0.797101449275362 17.5 17 5 increased sacral vertebrae number 1.67033303625804e-07 3.72641563021692e-06 0.867832648254203 0.796875 17.5 17 5 increased circulating alkaline phosphatase level 7.783872403118e-17 7.90301330724736e-15 0.867202413941745 0.796296296296296 17.5 17 5 increased B cell number 1.89254040983492e-12 9.60753932543745e-11 0.865651067941849 0.794871794871795 17.5 17 5 increased circulating alanine transaminase level 9.31619768423036e-09 2.75881449280036e-07 0.865651067941849 0.794871794871795 17.5 17 5 decreased trabecular bone volume 5.14880425579492e-05 0.000656802594168711 0.865651067941849 0.794871794871795 17.5 17 5 astrocytosis 2.89069425247154e-08 7.9454165226773e-07 0.865268544270642 0.794520547945205 17.5 17 5 dermatitis 8.74210928827149e-07 1.74666641402212e-05 0.863725259114393 0.793103448275862 17.5 17 5 decreased trophoblast giant cell number 0.0005309713276904 0.0048995032225062 0.863725259114393 0.793103448275862 17.5 17 5 abnormal inflammatory response 4.82838640087656e-08 1.23185755612107e-06 0.862160539442084 0.791666666666667 17.5 17 5 abnormal forebrain development 4.82838640087656e-08 1.23185755612107e-06 0.862160539442084 0.791666666666667 17.5 17 5 abnormal adrenal gland morphology 0.00173412701077122 0.01307163920998 0.862160539442084 0.791666666666667 17.5 17 5 abnormal nursing 0.00173412701077122 0.01307163920998 0.862160539442084 0.791666666666667 17.5 17 5 hemolytic anemia 0.00173412701077122 0.01307163920998 0.862160539442084 0.791666666666667 17.5 17 5 blindness 0.00173412701077122 0.01307163920998 0.862160539442084 0.791666666666667 17.5 17 5 small lymph nodes 0.00173412701077122 0.01307163920998 0.862160539442084 0.791666666666667 17.5 17 5 abnormal tumor morphology 0.00173412701077122 0.01307163920998 0.862160539442084 0.791666666666667 17.5 17 5 abnormal truncus arteriosus septation 0.00173412701077122 0.01307163920998 0.862160539442084 0.791666666666667 17.5 17 5 abnormal left-right axis patterning 2.71823992622054e-05 0.000379007536395153 0.861105263384015 0.790697674418605 17.5 17 5 abnormal double-strand DNA break repair 2.71823992622054e-05 0.000379007536395153 0.861105263384015 0.790697674418605 17.5 17 5 increased neuron apoptosis 8.37206727447639e-09 2.49407393356407e-07 0.860479914608863 0.790123456790123 17.5 17 5 absent vitelline blood vessels 1.45896890484705e-06 2.74938269000533e-05 0.859772283100139 0.789473684210526 17.5 17 5 kyphoscoliosis 0.00576453383277704 0.0348887540365764 0.859772283100139 0.789473684210526 17.5 17 5 abnormal stationary movement 0.00576453383277704 0.0348887540365764 0.859772283100139 0.789473684210526 17.5 17 5 altered susceptibility to infection 0.00576453383277704 0.0348887540365764 0.859772283100139 0.789473684210526 17.5 17 5 increased malignant tumor incidence 0.00576453383277704 0.0348887540365764 0.859772283100139 0.789473684210526 17.5 17 5 abnormal digestive system development 0.00576453383277704 0.0348887540365764 0.859772283100139 0.789473684210526 17.5 17 5 absent amnion 0.00576453383277704 0.0348887540365764 0.859772283100139 0.789473684210526 17.5 17 5 Leydig cell hypoplasia 0.00576453383277704 0.0348887540365764 0.859772283100139 0.789473684210526 17.5 17 5 decreased fertilization frequency 0.00576453383277704 0.0348887540365764 0.859772283100139 0.789473684210526 17.5 17 5 decreased circulating magnesium level 0.00576453383277704 0.0348887540365764 0.859772283100139 0.789473684210526 17.5 17 5 shortened RR interval 0.00576453383277704 0.0348887540365764 0.859772283100139 0.789473684210526 17.5 17 5 decreased brown adipose tissue amount 0.000275916917522916 0.00275087507951204 0.858035369396906 0.787878787878788 17.5 17 5 abnormal QRS complex 0.000275916917522916 0.00275087507951204 0.858035369396906 0.787878787878788 17.5 17 5 increased osteoblast cell number 0.000275916917522916 0.00275087507951204 0.858035369396906 0.787878787878788 17.5 17 5 myeloid hyperplasia 0.000275916917522916 0.00275087507951204 0.858035369396906 0.787878787878788 17.5 17 5 abnormal spleen germinal center morphology 0.000890207056380118 0.00746843188109795 0.855678129371091 0.785714285714286 17.5 17 5 straub tail 0.000890207056380118 0.00746843188109795 0.855678129371091 0.785714285714286 17.5 17 5 increased bone resorption 0.000890207056380118 0.00746843188109795 0.855678129371091 0.785714285714286 17.5 17 5 absent visceral yolk sac blood islands 0.0196932249147208 0.0954910272424329 0.855678129371091 0.785714285714286 17.5 17 5 increased lactate dehydrogenase level 0.0196932249147208 0.0954910272424329 0.855678129371091 0.785714285714286 17.5 17 5 abnormal sagittal suture morphology 0.0196932249147208 0.0954910272424329 0.855678129371091 0.785714285714286 17.5 17 5 increased stomach tumor incidence 0.0196932249147208 0.0954910272424329 0.855678129371091 0.785714285714286 17.5 17 5 decreased compact bone area 0.0196932249147208 0.0954910272424329 0.855678129371091 0.785714285714286 17.5 17 5 abnormal placenta morphology 2.30198879662108e-08 6.43392936134262e-07 0.854693459486889 0.784810126582278 17.5 17 5 abnormal response to infection 2.30198879662108e-08 6.43392936134262e-07 0.854693459486889 0.784810126582278 17.5 17 5 abnormal neural tube morphology 1.32667811966847e-15 1.11868197378824e-13 0.853757415275982 0.783950617283951 17.5 17 5 abnormal angiogenesis 7.1168777611211e-08 1.7686447474354e-06 0.853575726104823 0.783783783783784 17.5 17 5 malocclusion 0.000143757150002358 0.00161079239022912 0.853575726104823 0.783783783783784 17.5 17 5 increased erythroid progenitor cell number 0.000143757150002358 0.00161079239022912 0.853575726104823 0.783783783783784 17.5 17 5 increased trabecular bone volume 0.000143757150002358 0.00161079239022912 0.853575726104823 0.783783783783784 17.5 17 5 abnormal immune system morphology 2.38151202561798e-05 0.000339484880442677 0.852296002377529 0.782608695652174 17.5 17 5 abnormal sacral vertebrae morphology 0.00290786939584866 0.0197362213429019 0.852296002377529 0.782608695652174 17.5 17 5 abnormal chondrocyte physiology 0.00290786939584866 0.0197362213429019 0.852296002377529 0.782608695652174 17.5 17 5 decreased effector memory CD8-positive, alpha-beta T cell number 0.00290786939584866 0.0197362213429019 0.852296002377529 0.782608695652174 17.5 17 5 embryonic lethality during organogenesis, incomplete penetrance 2.33348031313593e-21 3.86968818595042e-19 0.852296002377529 0.782608695652174 17.5 17 5 abnormal head morphology 4.01056697072839e-06 6.80975108511049e-05 0.851435097324623 0.781818181818182 17.5 17 5 abnormal spongiotrophoblast layer morphology 0.000459246261595771 0.00431084934233766 0.850816321817846 0.78125 17.5 17 5 decreased susceptibility to parasitic infection 0.000459246261595771 0.00431084934233766 0.850816321817846 0.78125 17.5 17 5 increased fatty acid level 0.000459246261595771 0.00431084934233766 0.850816321817846 0.78125 17.5 17 5 pancreatic islet hyperplasia 0.000459246261595771 0.00431084934233766 0.850816321817846 0.78125 17.5 17 5 decreased birth body size 3.501942268421e-11 1.47645447333852e-09 0.85021925773236 0.780701754385965 17.5 17 5 small spleen 3.51974354690165e-09 1.08762261775377e-07 0.849694366228636 0.78021978021978 17.5 17 5 increased bone mineral content 1.07214877813428e-10 4.19995289072288e-09 0.849255190952125 0.779816513761468 17.5 17 5 abnormal thoracic vertebrae morphology 2.12174101003556e-06 3.82451504526337e-05 0.849085847942962 0.779661016949153 17.5 17 5 decreased birth weight 1.88139403520898e-09 6.03719619085601e-08 0.848308652658804 0.778947368421053 17.5 17 5 increased circulating aspartate transaminase level 1.12317218264318e-06 2.19128690535288e-05 0.8470349159431 0.777777777777778 17.5 17 5 abnormal cell migration 3.92927122542347e-05 0.000513074129828918 0.8470349159431 0.777777777777778 17.5 17 5 reduced long term depression 0.000237891541585133 0.00247079419496041 0.8470349159431 0.777777777777778 17.5 17 5 abnormal atrioventricular cushion morphology 0.00148013005576498 0.0114342345146441 0.8470349159431 0.777777777777778 17.5 17 5 abnormal trigeminal ganglion morphology 0.00148013005576498 0.0114342345146441 0.8470349159431 0.777777777777778 17.5 17 5 wrinkled skin 0.00148013005576498 0.0114342345146441 0.8470349159431 0.777777777777778 17.5 17 5 thick interventricular septum 0.00148013005576498 0.0114342345146441 0.8470349159431 0.777777777777778 17.5 17 5 blepharoptosis 0.00966801626646944 0.0542871116542726 0.8470349159431 0.777777777777778 17.5 17 5 abnormal metacarpal bone morphology 0.00966801626646944 0.0542871116542726 0.8470349159431 0.777777777777778 17.5 17 5 long tibia 0.00966801626646944 0.0542871116542726 0.8470349159431 0.777777777777778 17.5 17 5 increased susceptibility to autoimmune disorder 0.00966801626646944 0.0542871116542726 0.8470349159431 0.777777777777778 17.5 17 5 jerky movement 0.00966801626646944 0.0542871116542726 0.8470349159431 0.777777777777778 17.5 17 5 abnormal macrophage chemotaxis 0.00966801626646944 0.0542871116542726 0.8470349159431 0.777777777777778 17.5 17 5 impaired leukocyte tethering or rolling 0.00966801626646944 0.0542871116542726 0.8470349159431 0.777777777777778 17.5 17 5 increased adipocyte glucose uptake 0.00966801626646944 0.0542871116542726 0.8470349159431 0.777777777777778 17.5 17 5 thick tail 0.0705742148568447 0.234697004620857 0.8470349159431 0.777777777777778 17.5 17 5 abnormal sympathetic neuron morphology 0.0705742148568447 0.234697004620857 0.8470349159431 0.777777777777778 17.5 17 5 abnormal cholinergic neuron morphology 0.0705742148568447 0.234697004620857 0.8470349159431 0.777777777777778 17.5 17 5 abnormal kindling response 0.0705742148568447 0.234697004620857 0.8470349159431 0.777777777777778 17.5 17 5 multifocal hepatic necrosis 0.0705742148568447 0.234697004620857 0.8470349159431 0.777777777777778 17.5 17 5 abnormal lung volume 0.0705742148568447 0.234697004620857 0.8470349159431 0.777777777777778 17.5 17 5 increased pheochromocytoma incidence 0.0705742148568447 0.234697004620857 0.8470349159431 0.777777777777778 17.5 17 5 abnormal germ cell morphology 0.0705742148568447 0.234697004620857 0.8470349159431 0.777777777777778 17.5 17 5 abnormal thymus lobule morphology 0.0705742148568447 0.234697004620857 0.8470349159431 0.777777777777778 17.5 17 5 abnormal posterior semicircular canal morphology 0.0705742148568447 0.234697004620857 0.8470349159431 0.777777777777778 17.5 17 5 abnormal NMDA-mediated synaptic currents 0.0705742148568447 0.234697004620857 0.8470349159431 0.777777777777778 17.5 17 5 abnormal artery development 0.0705742148568447 0.234697004620857 0.8470349159431 0.777777777777778 17.5 17 5 premature bone ossification 0.0705742148568447 0.234697004620857 0.8470349159431 0.777777777777778 17.5 17 5 decreased fear-related response 0.0705742148568447 0.234697004620857 0.8470349159431 0.777777777777778 17.5 17 5 decreased vestibular hair cell number 0.0705742148568447 0.234697004620857 0.8470349159431 0.777777777777778 17.5 17 5 decreased cochlear hair cell number 0.0705742148568447 0.234697004620857 0.8470349159431 0.777777777777778 17.5 17 5 abnormal gallbladder physiology 0.0705742148568447 0.234697004620857 0.8470349159431 0.777777777777778 17.5 17 5 abnormal inguinal fat pad morphology 0.0705742148568447 0.234697004620857 0.8470349159431 0.777777777777778 17.5 17 5 decreased susceptibility to atherosclerosis 0.0705742148568447 0.234697004620857 0.8470349159431 0.777777777777778 17.5 17 5 absent cervical lymph nodes 0.0705742148568447 0.234697004620857 0.8470349159431 0.777777777777778 17.5 17 5 abnormal optic chiasm morphology 0.0705742148568447 0.234697004620857 0.8470349159431 0.777777777777778 17.5 17 5 axonal spheroids 0.0705742148568447 0.234697004620857 0.8470349159431 0.777777777777778 17.5 17 5 prolonged RR interval 0.0705742148568447 0.234697004620857 0.8470349159431 0.777777777777778 17.5 17 5 shortened ST segment 0.0705742148568447 0.234697004620857 0.8470349159431 0.777777777777778 17.5 17 5 iris coloboma 0.0705742148568447 0.234697004620857 0.8470349159431 0.777777777777778 17.5 17 5 abnormal pulmonary alveolar system morphology 0.0705742148568447 0.234697004620857 0.8470349159431 0.777777777777778 17.5 17 5 reduced AMPA-mediated synaptic currents 0.0705742148568447 0.234697004620857 0.8470349159431 0.777777777777778 17.5 17 5 decreased bone trabecular spacing 0.0705742148568447 0.234697004620857 0.8470349159431 0.777777777777778 17.5 17 5 increased myeloid cell number 0.0705742148568447 0.234697004620857 0.8470349159431 0.777777777777778 17.5 17 5 trigeminal neuroma 0.0705742148568447 0.234697004620857 0.8470349159431 0.777777777777778 17.5 17 5 symmetric azygos veins 0.0705742148568447 0.234697004620857 0.8470349159431 0.777777777777778 17.5 17 5 cerebellum atrophy 0.0705742148568447 0.234697004620857 0.8470349159431 0.777777777777778 17.5 17 5 abnormal craniofacial morphology 5.37371087355441e-10 1.96575085264215e-08 0.845860110234441 0.776699029126214 17.5 17 5 abnormal extraembryonic tissue morphology 8.77212241717723e-10 3.09512829967778e-08 0.843475945708045 0.774509803921569 17.5 17 5 pericardial effusion 1.83898277331917e-06 3.41378331987421e-05 0.843131529233685 0.774193548387097 17.5 17 5 decreased thymus weight 0.000758612113493958 0.00650706080109042 0.843131529233685 0.774193548387097 17.5 17 5 decreased hemoglobin content 7.24504715341439e-13 3.83447974342942e-11 0.841885767517914 0.773049645390071 17.5 17 5 lethality, incomplete penetrance 6.44602351389045e-05 0.000801724174540125 0.841534689216197 0.772727272727273 17.5 17 5 intracerebral hemorrhage 0.00482753493523208 0.0305171363440656 0.841534689216197 0.772727272727273 17.5 17 5 increased myocardial infarction size 0.00482753493523208 0.0305171363440656 0.841534689216197 0.772727272727273 17.5 17 5 prolonged PR interval 0.00482753493523208 0.0305171363440656 0.841534689216197 0.772727272727273 17.5 17 5 abnormal blood-brain barrier function 0.00482753493523208 0.0305171363440656 0.841534689216197 0.772727272727273 17.5 17 5 abnormal occipital bone morphology 0.00482753493523208 0.0305171363440656 0.841534689216197 0.772727272727273 17.5 17 5 abnormal sperm midpiece morphology 0.00482753493523208 0.0305171363440656 0.841534689216197 0.772727272727273 17.5 17 5 pulmonary vascular congestion 0.00482753493523208 0.0305171363440656 0.841534689216197 0.772727272727273 17.5 17 5 increased leukocyte cell number 3.8770561137727e-13 2.16723080517069e-11 0.841193295833148 0.772413793103448 17.5 17 5 increased neutrophil cell number 3.8770561137727e-13 2.16723080517069e-11 0.841193295833148 0.772413793103448 17.5 17 5 abnormal somite development 8.87031450377499e-08 2.12162570462887e-06 0.840908081108068 0.772151898734177 17.5 17 5 abnormal placenta labyrinth morphology 8.87031450377499e-08 2.12162570462887e-06 0.840908081108068 0.772151898734177 17.5 17 5 abnormal nervous system morphology 8.87031450377499e-08 2.12162570462887e-06 0.840908081108068 0.772151898734177 17.5 17 5 decreased susceptibility to induced arthritis 5.69189894889661e-06 9.40770673447198e-05 0.84066623236458 0.771929824561403 17.5 17 5 holoprosencephaly 0.000390934444192938 0.0037330112473318 0.840120345200707 0.771428571428571 17.5 17 5 decreased glycogen level 0.000390934444192938 0.0037330112473318 0.840120345200707 0.771428571428571 17.5 17 5 decreased bone mineralization 0.000390934444192938 0.0037330112473318 0.840120345200707 0.771428571428571 17.5 17 5 curly tail 3.36869307402079e-05 0.000457902952001459 0.839472104193608 0.770833333333333 17.5 17 5 ventricular hypoplasia 0.00243906257915007 0.01718744522843 0.837726839943725 0.769230769230769 17.5 17 5 abnormal Mullerian duct morphology 0.00243906257915007 0.01718744522843 0.837726839943725 0.769230769230769 17.5 17 5 short premaxilla 0.0330313386158722 0.137515405534698 0.837726839943725 0.769230769230769 17.5 17 5 abnormal renal/urinary system morphology 0.0330313386158722 0.137515405534698 0.837726839943725 0.769230769230769 17.5 17 5 abnormal grip strength 0.0330313386158722 0.137515405534698 0.837726839943725 0.769230769230769 17.5 17 5 increased pituitary adenoma incidence 0.0330313386158722 0.137515405534698 0.837726839943725 0.769230769230769 17.5 17 5 abnormal telomere length 0.0330313386158722 0.137515405534698 0.837726839943725 0.769230769230769 17.5 17 5 increased cochlear inner hair cell number 0.0330313386158722 0.137515405534698 0.837726839943725 0.769230769230769 17.5 17 5 small pituitary gland 0.0330313386158722 0.137515405534698 0.837726839943725 0.769230769230769 17.5 17 5 orthokeratosis 0.0330313386158722 0.137515405534698 0.837726839943725 0.769230769230769 17.5 17 5 failure of heart looping 0.000202348658695976 0.00216026733264481 0.837726839943725 0.769230769230769 17.5 17 5 seminiferous tubule degeneration 4.40957377560897e-07 9.1406789723561e-06 0.835431697916482 0.767123287671233 17.5 17 5 intracranial hemorrhage 4.86527045280573e-06 8.17727044010422e-05 0.834934417143913 0.766666666666667 17.5 17 5 abnormal spleen marginal zone morphology 0.00124302767208453 0.00994222293990441 0.834934417143913 0.766666666666667 17.5 17 5 abnormal optic cup morphology 0.00124302767208453 0.00994222293990441 0.834934417143913 0.766666666666667 17.5 17 5 hemorrhage 1.55877552140595e-19 2.04076532078806e-17 0.834162044880135 0.765957446808511 17.5 17 5 decreased bone trabecula number 5.47731284939689e-05 0.000695143658820141 0.834162044880135 0.765957446808511 17.5 17 5 lung hemorrhage 0.000637711219470003 0.00558558682546349 0.83279903500288 0.764705882352941 17.5 17 5 abnormal endoderm development 0.000637711219470003 0.00558558682546349 0.83279903500288 0.764705882352941 17.5 17 5 abnormal nervous system development 0.000637711219470003 0.00558558682546349 0.83279903500288 0.764705882352941 17.5 17 5 increased susceptibility to viral infection induced morbidity/mortality 0.000637711219470003 0.00558558682546349 0.83279903500288 0.764705882352941 17.5 17 5 aminoaciduria 0.0160121575471124 0.0800607877355619 0.83279903500288 0.764705882352941 17.5 17 5 abnormal involuntary movement 0.0160121575471124 0.0800607877355619 0.83279903500288 0.764705882352941 17.5 17 5 increased brain size 0.0160121575471124 0.0800607877355619 0.83279903500288 0.764705882352941 17.5 17 5 coloboma 0.0160121575471124 0.0800607877355619 0.83279903500288 0.764705882352941 17.5 17 5 increased hepatoma incidence 0.0160121575471124 0.0800607877355619 0.83279903500288 0.764705882352941 17.5 17 5 kinked tail 3.21832792738196e-09 1.00069883992033e-07 0.83279903500288 0.764705882352941 17.5 17 5 abnormal gastrulation 2.86142589458207e-05 0.000396534646951137 0.83279903500288 0.764705882352941 17.5 17 5 abnormal trophoblast layer morphology 2.86142589458207e-05 0.000396534646951137 0.83279903500288 0.764705882352941 17.5 17 5 abnormal joint morphology 1.49816351856194e-05 0.000228467068272189 0.831634281107771 0.763636363636364 17.5 17 5 increased bone marrow cell number 0.000328890311562476 0.00324005801984815 0.831113206996801 0.763157894736842 17.5 17 5 prenatal lethality, complete penetrance 2.53243331812751e-22 5.72675261712926e-20 0.830494665785938 0.762589928057554 17.5 17 5 increased heart weight 6.86879577359334e-12 3.13506963060797e-10 0.830494665785938 0.762589928057554 17.5 17 5 abnormal pancreas morphology 0.000170345030145865 0.00186256379115534 0.829748489087118 0.761904761904762 17.5 17 5 abnormal anxiety-related response 0.00792742263388385 0.0455414868401526 0.829748489087118 0.761904761904762 17.5 17 5 liver degeneration 0.00792742263388385 0.0455414868401526 0.829748489087118 0.761904761904762 17.5 17 5 complete atrioventricular septal defect 0.00792742263388385 0.0455414868401526 0.829748489087118 0.761904761904762 17.5 17 5 internal hemorrhage 2.17310812174434e-06 3.90296494789823e-05 0.828974469974164 0.761194029850746 17.5 17 5 abnormal allantois morphology 8.85395958844093e-05 0.0010537906447965 0.828621113422598 0.760869565217391 17.5 17 5 decreased circulating alkaline phosphatase level 4.61561114967238e-05 0.000593350528930751 0.8276741178644 0.76 17.5 17 5 increased cell proliferation 2.41219220164619e-05 0.000341899037127914 0.826867417944455 0.759259259259259 17.5 17 5 abnormal neuronal precursor proliferation 2.41219220164619e-05 0.000341899037127914 0.826867417944455 0.759259259259259 17.5 17 5 abnormal behavior 8.87717675842235e-22 1.5772840847554e-19 0.826577238117136 0.758992805755396 17.5 17 5 polychromatophilia 0.00201923363226208 0.01478991175956 0.826171986978984 0.758620689655172 17.5 17 5 abnormal aorta morphology 0.00103215046182344 0.00854400756667494 0.825034009035487 0.757575757575758 17.5 17 5 enlarged pericardium 0.00103215046182344 0.00854400756667494 0.825034009035487 0.757575757575758 17.5 17 5 decreased circulating chloride level 0.000530754093175988 0.0048995032225062 0.82414208037707 0.756756756756757 17.5 17 5 abnormal calcium ion homeostasis 0.000530754093175988 0.0048995032225062 0.82414208037707 0.756756756756757 17.5 17 5 abnormal respiratory electron transport chain 0.000530754093175988 0.0048995032225062 0.82414208037707 0.756756756756757 17.5 17 5 liver fibrosis 0.000274235007143473 0.00275087507951204 0.823424186578832 0.75609756097561 17.5 17 5 increased tumor growth/size 0.000274235007143473 0.00275087507951204 0.823424186578832 0.75609756097561 17.5 17 5 abnormal cell differentiation 0.000274235007143473 0.00275087507951204 0.823424186578832 0.75609756097561 17.5 17 5 trabecula carnea hypoplasia 0.000142250760418793 0.00160475631084693 0.822833918344726 0.755555555555556 17.5 17 5 small placenta 0.000142250760418793 0.00160475631084693 0.822833918344726 0.755555555555556 17.5 17 5 increased circulating bilirubin level 3.86322394267569e-05 0.00050577734512662 0.821920673152334 0.754716981132076 17.5 17 5 increased macrophage cell number 2.02077888886149e-05 0.000292249272444358 0.821560181629022 0.754385964912281 17.5 17 5 increased osteoclast cell number 1.05918129502297e-05 0.000166754017175294 0.821246967682537 0.754098360655738 17.5 17 5 decreased neutrophil cell number 1.40987185763549e-09 4.64510761042156e-08 0.819110687944976 0.752136752136752 17.5 17 5 decreased body length 1.93012752408394e-20 2.66732900897712e-18 0.818770977142079 0.751824817518248 17.5 17 5 perinatal lethality, complete penetrance 3.81337187808335e-16 3.51324538767865e-14 0.818061890649271 0.751173708920188 17.5 17 5 abnormal spermatogenesis 4.92109956669605e-14 3.35376306086477e-12 0.816783668945132 0.75 17.5 17 5 abnormal pericardium morphology 0.0128628735894295 0.0672900064220946 0.816783668945132 0.75 17.5 17 5 abnormal cell proliferation 0.0128628735894295 0.0672900064220946 0.816783668945132 0.75 17.5 17 5 brain inflammation 0.0128628735894295 0.0672900064220946 0.816783668945132 0.75 17.5 17 5 abnormal hyoid bone morphology 0.0128628735894295 0.0672900064220946 0.816783668945132 0.75 17.5 17 5 abnormal physiological neovascularization 0.0128628735894295 0.0672900064220946 0.816783668945132 0.75 17.5 17 5 dilated vasculature 0.0128628735894295 0.0672900064220946 0.816783668945132 0.75 17.5 17 5 kidney atrophy 0.0128628735894295 0.0672900064220946 0.816783668945132 0.75 17.5 17 5 abnormal response to tactile stimuli 0.0128628735894295 0.0672900064220946 0.816783668945132 0.75 17.5 17 5 decreased muscle cell glucose uptake 0.0128628735894295 0.0672900064220946 0.816783668945132 0.75 17.5 17 5 abnormal immune system physiology 6.29267725821271e-10 2.26855575069625e-08 0.816783668945132 0.75 17.5 17 5 enlarged liver 2.81496003302305e-08 7.78023675793872e-07 0.816783668945132 0.75 17.5 17 5 decreased circulating LDL cholesterol level 8.83615654976083e-06 0.000142983086220446 0.816783668945132 0.75 17.5 17 5 abnormal long bone epiphyseal plate morphology 1.68403004103683e-05 0.000253113276560671 0.816783668945132 0.75 17.5 17 5 abnormal astrocyte morphology 0.000227087841980977 0.00236351885743799 0.816783668945132 0.75 17.5 17 5 decreased macrophage cell number 0.000227087841980977 0.00236351885743799 0.816783668945132 0.75 17.5 17 5 decreased blood urea nitrogen level 0.000227087841980977 0.00236351885743799 0.816783668945132 0.75 17.5 17 5 abnormal retinal blood vessel morphology 0.000850063152016349 0.0072539694361601 0.816783668945132 0.75 17.5 17 5 scoliosis 0.00165670966918852 0.0126607228943362 0.816783668945132 0.75 17.5 17 5 failure of primitive streak formation 0.00165670966918852 0.0126607228943362 0.816783668945132 0.75 17.5 17 5 rib bifurcation 0.00324989905391958 0.0218489835043918 0.816783668945132 0.75 17.5 17 5 premature aging 0.00324989905391958 0.0218489835043918 0.816783668945132 0.75 17.5 17 5 hypoxia 0.00324989905391958 0.0218489835043918 0.816783668945132 0.75 17.5 17 5 abnormal renal tubule epithelium morphology 0.00324989905391958 0.0218489835043918 0.816783668945132 0.75 17.5 17 5 decreased body height 0.006429096551081 0.0386289315720144 0.816783668945132 0.75 17.5 17 5 decreased metastatic potential 0.006429096551081 0.0386289315720144 0.816783668945132 0.75 17.5 17 5 ocular hypertelorism 0.006429096551081 0.0386289315720144 0.816783668945132 0.75 17.5 17 5 failure of tooth eruption 0.0261493666982943 0.115976836236329 0.816783668945132 0.75 17.5 17 5 sepsis 0.0261493666982943 0.115976836236329 0.816783668945132 0.75 17.5 17 5 blepharitis 0.0261493666982943 0.115976836236329 0.816783668945132 0.75 17.5 17 5 dystonia 0.0261493666982943 0.115976836236329 0.816783668945132 0.75 17.5 17 5 abnormal Langerhans cell physiology 0.0261493666982943 0.115976836236329 0.816783668945132 0.75 17.5 17 5 abnormal thoracic cage shape 0.0261493666982943 0.115976836236329 0.816783668945132 0.75 17.5 17 5 increased heart left ventricle size 0.0261493666982943 0.115976836236329 0.816783668945132 0.75 17.5 17 5 decreased adipocyte glucose uptake 0.0261493666982943 0.115976836236329 0.816783668945132 0.75 17.5 17 5 amyloidosis 0.054468789382247 0.191236575283471 0.816783668945132 0.75 17.5 17 5 abnormal superior cervical ganglion morphology 0.054468789382247 0.191236575283471 0.816783668945132 0.75 17.5 17 5 abnormal mating frequency 0.054468789382247 0.191236575283471 0.816783668945132 0.75 17.5 17 5 myocarditis 0.054468789382247 0.191236575283471 0.816783668945132 0.75 17.5 17 5 decreased synaptic depression 0.054468789382247 0.191236575283471 0.816783668945132 0.75 17.5 17 5 loss of dopaminergic neurons 0.054468789382247 0.191236575283471 0.816783668945132 0.75 17.5 17 5 absent tail 0.054468789382247 0.191236575283471 0.816783668945132 0.75 17.5 17 5 abnormal nucleotide metabolism 0.054468789382247 0.191236575283471 0.816783668945132 0.75 17.5 17 5 increased hepatocyte proliferation 0.054468789382247 0.191236575283471 0.816783668945132 0.75 17.5 17 5 pale placenta 0.054468789382247 0.191236575283471 0.816783668945132 0.75 17.5 17 5 vestibular saccular macula degeneration 0.054468789382247 0.191236575283471 0.816783668945132 0.75 17.5 17 5 bowed ulna 0.054468789382247 0.191236575283471 0.816783668945132 0.75 17.5 17 5 abnormal cochlear outer hair cell physiology 0.054468789382247 0.191236575283471 0.816783668945132 0.75 17.5 17 5 decreased prostaglandin level 0.054468789382247 0.191236575283471 0.816783668945132 0.75 17.5 17 5 decreased mammary gland epithelial cell proliferation 0.054468789382247 0.191236575283471 0.816783668945132 0.75 17.5 17 5 increased skeletal muscle glycogen level 0.054468789382247 0.191236575283471 0.816783668945132 0.75 17.5 17 5 abnormal ear pigmentation 0.118299821178149 0.319165732300051 0.816783668945132 0.75 17.5 17 5 abnormal bone marrow development 0.118299821178149 0.319165732300051 0.816783668945132 0.75 17.5 17 5 absent pre-B cells 0.118299821178149 0.319165732300051 0.816783668945132 0.75 17.5 17 5 enlarged pituitary gland 0.118299821178149 0.319165732300051 0.816783668945132 0.75 17.5 17 5 dry eyes 0.118299821178149 0.319165732300051 0.816783668945132 0.75 17.5 17 5 abnormal erythrocyte cell number 0.118299821178149 0.319165732300051 0.816783668945132 0.75 17.5 17 5 abnormal urination 0.118299821178149 0.319165732300051 0.816783668945132 0.75 17.5 17 5 abnormal atrial thrombosis 0.118299821178149 0.319165732300051 0.816783668945132 0.75 17.5 17 5 abnormal hepatobiliary system morphology 0.118299821178149 0.319165732300051 0.816783668945132 0.75 17.5 17 5 joint swelling 0.118299821178149 0.319165732300051 0.816783668945132 0.75 17.5 17 5 vascular smooth muscle hypertrophy 0.118299821178149 0.319165732300051 0.816783668945132 0.75 17.5 17 5 short ureter 0.118299821178149 0.319165732300051 0.816783668945132 0.75 17.5 17 5 decreased aerobic running capacity 0.118299821178149 0.319165732300051 0.816783668945132 0.75 17.5 17 5 hypospadia 0.118299821178149 0.319165732300051 0.816783668945132 0.75 17.5 17 5 abnormal soft palate morphology 0.118299821178149 0.319165732300051 0.816783668945132 0.75 17.5 17 5 abnormal neuron apoptosis 0.118299821178149 0.319165732300051 0.816783668945132 0.75 17.5 17 5 decreased susceptibility to age related obesity 0.118299821178149 0.319165732300051 0.816783668945132 0.75 17.5 17 5 abnormal umbilical artery morphology 0.118299821178149 0.319165732300051 0.816783668945132 0.75 17.5 17 5 increased cardiac output 0.118299821178149 0.319165732300051 0.816783668945132 0.75 17.5 17 5 abnormal platelet shape 0.118299821178149 0.319165732300051 0.816783668945132 0.75 17.5 17 5 tau protein deposits 0.118299821178149 0.319165732300051 0.816783668945132 0.75 17.5 17 5 long femur 0.118299821178149 0.319165732300051 0.816783668945132 0.75 17.5 17 5 absent interparietal bone 0.118299821178149 0.319165732300051 0.816783668945132 0.75 17.5 17 5 abnormal choroid pigmentation 0.118299821178149 0.319165732300051 0.816783668945132 0.75 17.5 17 5 abnormal canal of Schlemm morphology 0.118299821178149 0.319165732300051 0.816783668945132 0.75 17.5 17 5 ocular hypertension 0.118299821178149 0.319165732300051 0.816783668945132 0.75 17.5 17 5 stomach epithelial hyperplasia 0.118299821178149 0.319165732300051 0.816783668945132 0.75 17.5 17 5 choroidal neovascularization 0.118299821178149 0.319165732300051 0.816783668945132 0.75 17.5 17 5 enlarged inguinal lymph nodes 0.118299821178149 0.319165732300051 0.816783668945132 0.75 17.5 17 5 abnormal base-excision repair 0.118299821178149 0.319165732300051 0.816783668945132 0.75 17.5 17 5 abnormal sphingomyelin level 0.118299821178149 0.319165732300051 0.816783668945132 0.75 17.5 17 5 abnormal frontonasal prominence morphology 0.118299821178149 0.319165732300051 0.816783668945132 0.75 17.5 17 5 abnormal olfactory bulb glomerular layer morphology 0.118299821178149 0.319165732300051 0.816783668945132 0.75 17.5 17 5 increased caudal vertebrae number 0.118299821178149 0.319165732300051 0.816783668945132 0.75 17.5 17 5 abnormal brain ependyma morphology 0.118299821178149 0.319165732300051 0.816783668945132 0.75 17.5 17 5 myocardial trabeculae hypoplasia 0.118299821178149 0.319165732300051 0.816783668945132 0.75 17.5 17 5 increased heart right ventricle size 0.118299821178149 0.319165732300051 0.816783668945132 0.75 17.5 17 5 abnormal visual evoked potential 0.118299821178149 0.319165732300051 0.816783668945132 0.75 17.5 17 5 increased susceptibility to parasitic infection induced morbidity/mortality 0.118299821178149 0.319165732300051 0.816783668945132 0.75 17.5 17 5 lung situs inversus 0.118299821178149 0.319165732300051 0.816783668945132 0.75 17.5 17 5 abnormal bronchiole epithelium morphology 0.118299821178149 0.319165732300051 0.816783668945132 0.75 17.5 17 5 abnormal maxillary prominence morphology 0.118299821178149 0.319165732300051 0.816783668945132 0.75 17.5 17 5 absent ureteric bud 0.118299821178149 0.319165732300051 0.816783668945132 0.75 17.5 17 5 increased aorta wall thickness 0.118299821178149 0.319165732300051 0.816783668945132 0.75 17.5 17 5 abnormal heart echocardiography feature 0.118299821178149 0.319165732300051 0.816783668945132 0.75 17.5 17 5 small thymus medulla 0.118299821178149 0.319165732300051 0.816783668945132 0.75 17.5 17 5 increased testis apoptosis 0.118299821178149 0.319165732300051 0.816783668945132 0.75 17.5 17 5 increased mammary gland apoptosis 0.118299821178149 0.319165732300051 0.816783668945132 0.75 17.5 17 5 decreased circulating cholesterol level 7.75760190844698e-14 5.07816703875312e-12 0.81529590269933 0.748633879781421 17.5 17 5 abnormal liver morphology 1.45559647120081e-13 9.12496501071058e-12 0.81526265652624 0.748603351955307 17.5 17 5 preweaning lethality, incomplete penetrance 5.00817629304472e-29 1.66104513719316e-26 0.814786642859692 0.748166259168704 17.5 17 5 kyphosis 1.88139997395039e-11 8.21049550035368e-10 0.813153519305376 0.746666666666667 17.5 17 5 delayed bone ossification 2.03475582519298e-06 3.72165817291731e-05 0.813153519305376 0.746666666666667 17.5 17 5 abnormal neurocranium morphology 2.03475582519298e-06 3.72165817291731e-05 0.813153519305376 0.746666666666667 17.5 17 5 abnormal rostral-caudal axis patterning 5.08899048782147e-05 0.000650841328455317 0.811833464890919 0.745454545454545 17.5 17 5 failure of chorioallantoic fusion 9.74322958762863e-05 0.00115254833286799 0.811445213592549 0.745098039215686 17.5 17 5 neuron degeneration 0.000187025125773192 0.00200528017396903 0.810990876966798 0.74468085106383 17.5 17 5 abnormal vasculogenesis 0.000360098901553698 0.00347188378920474 0.81045201259672 0.744186046511628 17.5 17 5 abnormal homeostasis 0.000360098901553698 0.00347188378920474 0.81045201259672 0.744186046511628 17.5 17 5 impaired macrophage phagocytosis 0.000360098901553698 0.00347188378920474 0.81045201259672 0.744186046511628 17.5 17 5 increased rib number 1.68821222812735e-06 3.15746459959909e-05 0.809802611945601 0.743589743589744 17.5 17 5 abnormal liver development 0.00135062190360376 0.0105318871009854 0.80900477685994 0.742857142857143 17.5 17 5 abnormal dermal layer morphology 0.00135062190360376 0.0105318871009854 0.80900477685994 0.742857142857143 17.5 17 5 abnormal embryonic epiblast morphology 0.00135062190360376 0.0105318871009854 0.80900477685994 0.742857142857143 17.5 17 5 decreased triglyceride level 0.00135062190360376 0.0105318871009854 0.80900477685994 0.742857142857143 17.5 17 5 decreased bone volume 0.00135062190360376 0.0105318871009854 0.80900477685994 0.742857142857143 17.5 17 5 increased lung adenoma incidence 0.00263572240303243 0.0183651525981601 0.808001048848948 0.741935483870968 17.5 17 5 abnormal postnatal growth/weight/body size 0.00263572240303243 0.0183651525981601 0.808001048848948 0.741935483870968 17.5 17 5 pale kidney 0.00263572240303243 0.0183651525981601 0.808001048848948 0.741935483870968 17.5 17 5 small cranium 0.00263572240303243 0.0183651525981601 0.808001048848948 0.741935483870968 17.5 17 5 abnormal spermiogenesis 4.19200604575267e-05 0.000543937837516161 0.80739535091128 0.741379310344828 17.5 17 5 abnormal chondrocyte morphology 8.00902891704573e-05 0.000957810549574579 0.806699919945809 0.740740740740741 17.5 17 5 abnormal skin appearance 0.00517886978882169 0.032481496049023 0.806699919945809 0.740740740740741 17.5 17 5 decreased bone ossification 0.00517886978882169 0.032481496049023 0.806699919945809 0.740740740740741 17.5 17 5 abnormal heart development 1.7051898868361e-11 7.57439257768713e-10 0.806444635161016 0.740506329113924 17.5 17 5 cleft palate 8.99353244126403e-10 3.1509030912175e-08 0.806392019213006 0.740458015267176 17.5 17 5 abnormal liver physiology 9.07172168476786e-08 2.15941700391005e-06 0.805893220025864 0.74 17.5 17 5 testicular atrophy 0.000153360744855154 0.00169926437784942 0.805893220025864 0.74 17.5 17 5 abnormal circulating protein level 0.000153360744855154 0.00169926437784942 0.805893220025864 0.74 17.5 17 5 decreased oocyte number 0.000153360744855154 0.00169926437784942 0.805893220025864 0.74 17.5 17 5 decreased hematocrit 1.1266982331507e-10 4.34521217823624e-09 0.805594851562322 0.73972602739726 17.5 17 5 abnormal fertility/fecundity 5.01347846093602e-06 8.3979984320393e-05 0.805594851562322 0.73972602739726 17.5 17 5 abnormal myelin sheath morphology 0.000294432393266216 0.00292960231299885 0.804946224467667 0.739130434782609 17.5 17 5 pancreas inflammation 0.0102665872968184 0.0570684601135996 0.804946224467667 0.739130434782609 17.5 17 5 abnormal cardiovascular development 0.0102665872968184 0.0570684601135996 0.804946224467667 0.739130434782609 17.5 17 5 abnormal Wolffian duct morphology 0.0102665872968184 0.0570684601135996 0.804946224467667 0.739130434782609 17.5 17 5 dilated heart 0.0102665872968184 0.0570684601135996 0.804946224467667 0.739130434782609 17.5 17 5 abnormal sternum morphology 9.51508359946012e-06 0.000152701744862304 0.804946224467666 0.739130434782609 17.5 17 5 increased lymphocyte cell number 9.51508359946012e-06 0.000152701744862304 0.804946224467666 0.739130434782609 17.5 17 5 decreased monocyte cell number 1.80823186717893e-05 0.000266942241519738 0.804217766345976 0.738461538461539 17.5 17 5 edema 3.33983872158643e-12 1.59766323460505e-10 0.804120356248308 0.738372093023256 17.5 17 5 disheveled coat 0.000567015851409454 0.00513825839847365 0.803818848803146 0.738095238095238 17.5 17 5 enlarged heart 8.4674066552938e-16 7.39041194913801e-14 0.802701191894354 0.737068965517241 17.5 17 5 enlarged adrenal glands 0.0205977670808081 0.0989130224199037 0.802454130893463 0.736842105263158 17.5 17 5 abnormal optic vesicle formation 0.0205977670808081 0.0989130224199037 0.802454130893463 0.736842105263158 17.5 17 5 osteoarthritis 0.0205977670808081 0.0989130224199037 0.802454130893463 0.736842105263158 17.5 17 5 decreased eye pigmentation 0.0205977670808081 0.0989130224199037 0.802454130893463 0.736842105263158 17.5 17 5 embryonic lethality between implantation and somite formation, incomplete penetrance 0.0205977670808081 0.0989130224199037 0.802454130893463 0.736842105263158 17.5 17 5 abnormal facial morphology 6.56069060846591e-05 0.000810096470878924 0.802454130893463 0.736842105263158 17.5 17 5 premature death 9.89480844863314e-55 8.20444533865831e-52 0.80192155805066 0.736353077816492 17.5 17 5 abnormal heart morphology 1.3121943049889e-15 1.11868197378824e-13 0.80146160877733 0.735930735930736 17.5 17 5 abnormal coat/ hair morphology 0.00012531283219644 0.00143979524290367 0.801372656323526 0.735849056603774 17.5 17 5 atrioventricular septal defect 0.00012531283219644 0.00143979524290367 0.801372656323526 0.735849056603774 17.5 17 5 cataract 7.67277933216439e-09 2.29952272153722e-07 0.801033019681727 0.735537190082645 17.5 17 5 lung inflammation 9.56847360853598e-10 3.3057747362824e-08 0.800768302887384 0.735294117647059 17.5 17 5 ventricular septal defect 9.56847360853598e-10 3.3057747362824e-08 0.800768302887384 0.735294117647059 17.5 17 5 decreased mean corpuscular hemoglobin 1.48309475612846e-05 0.000227027581899664 0.800768302887384 0.735294117647059 17.5 17 5 abnormal oocyte morphology 0.00212781502391635 0.0153641215442436 0.800768302887384 0.735294117647059 17.5 17 5 abnormal brown adipose tissue morphology 0.00212781502391635 0.0153641215442436 0.800768302887384 0.735294117647059 17.5 17 5 increased circulating LDL cholesterol level 0.000239884537222343 0.00247598666531361 0.800114614476864 0.73469387755102 17.5 17 5 abnormal craniofacial development 0.000239884537222343 0.00247598666531361 0.800114614476864 0.73469387755102 17.5 17 5 abnormal eye morphology 7.89165691750723e-10 2.80435665461418e-08 0.799155244435525 0.733812949640288 17.5 17 5 increased susceptibility to parasitic infection 7.79120847716548e-07 1.56928186938859e-05 0.798632920746351 0.733333333333333 17.5 17 5 muscular ventricular septal defect 5.35875413441281e-05 0.000681836363649712 0.798632920746351 0.733333333333333 17.5 17 5 irregular heartbeat 0.000460389816276982 0.00431344507717135 0.798632920746351 0.733333333333333 17.5 17 5 abnormal heart tube morphology 0.00415380002275036 0.026561896032369 0.798632920746351 0.733333333333333 17.5 17 5 abnormal microglial cell physiology 0.00415380002275036 0.026561896032369 0.798632920746351 0.733333333333333 17.5 17 5 audiogenic seizures 0.0420354503761172 0.166634554279827 0.798632920746351 0.733333333333333 17.5 17 5 abnormal seizure response to electrical stimulation 0.0420354503761172 0.166634554279827 0.798632920746351 0.733333333333333 17.5 17 5 absent egg cylinders 0.0420354503761172 0.166634554279827 0.798632920746351 0.733333333333333 17.5 17 5 increased airway responsiveness 0.0420354503761172 0.166634554279827 0.798632920746351 0.733333333333333 17.5 17 5 arthritis 0.0420354503761172 0.166634554279827 0.798632920746351 0.733333333333333 17.5 17 5 delayed intramembranous bone ossification 0.0420354503761172 0.166634554279827 0.798632920746351 0.733333333333333 17.5 17 5 abnormal pericyte morphology 0.0420354503761172 0.166634554279827 0.798632920746351 0.733333333333333 17.5 17 5 immune system phenotype 0.0420354503761172 0.166634554279827 0.798632920746351 0.733333333333333 17.5 17 5 absent chorion 0.0420354503761172 0.166634554279827 0.798632920746351 0.733333333333333 17.5 17 5 liver vascular congestion 0.0420354503761172 0.166634554279827 0.798632920746351 0.733333333333333 17.5 17 5 bicuspid aortic valve 0.0420354503761172 0.166634554279827 0.798632920746351 0.733333333333333 17.5 17 5 decreased trabecular bone mass 0.0420354503761172 0.166634554279827 0.798632920746351 0.733333333333333 17.5 17 5 ataxia 1.62481006361784e-13 9.97954329197379e-12 0.797914079233528 0.732673267326733 17.5 17 5 increased circulating free fatty acid level 1.21346171574278e-05 0.000187483603596904 0.79761034338304 0.732394366197183 17.5 17 5 abnormal coat/hair pigmentation 4.18794839883985e-08 1.08453947407617e-06 0.797336438732153 0.732142857142857 17.5 17 5 sparse hair 2.77436350736828e-06 4.91190692140825e-05 0.796862116044031 0.731707317073171 17.5 17 5 abnormal mammary gland development 0.000886258780742355 0.00746843188109795 0.796862116044031 0.731707317073171 17.5 17 5 Leydig cell hyperplasia 0.000886258780742355 0.00746843188109795 0.796862116044031 0.731707317073171 17.5 17 5 scaly skin 0.000886258780742355 0.00746843188109795 0.796862116044031 0.731707317073171 17.5 17 5 abnormal axon morphology 7.8686342275603e-08 1.92839681192672e-06 0.796616170946487 0.731481481481482 17.5 17 5 rib fusion 2.30047426731696e-05 0.000328875272410974 0.796465667230079 0.73134328358209 17.5 17 5 thick skin 0.00816495559970795 0.0467979886043169 0.795840497946539 0.730769230769231 17.5 17 5 pulmonary edema 0.00816495559970795 0.0467979886043169 0.795840497946539 0.730769230769231 17.5 17 5 increased urine protein level 5.24076115768209e-06 8.71999557172856e-05 0.795840497946539 0.730769230769231 17.5 17 5 abnormal branching of the mammary ductal tree 0.00171219761088533 0.0130446908333147 0.794708434649318 0.72972972972973 17.5 17 5 decreased circulating calcium level 0.000157957980616438 0.00173474824186927 0.792032648674068 0.727272727272727 17.5 17 5 abnormal ovarian folliculogenesis 0.0033222008888287 0.022244884820892 0.792032648674068 0.727272727272727 17.5 17 5 abnormal skeleton physiology 0.0033222008888287 0.022244884820892 0.792032648674068 0.727272727272727 17.5 17 5 muscular atrophy 0.00071479506041429 0.00614180557091726 0.792032648674067 0.727272727272727 17.5 17 5 abnormal abdominal fat pad morphology 0.0161937898302885 0.0804836207849005 0.792032648674067 0.727272727272727 17.5 17 5 abnormal germ layer development 0.0161937898302885 0.0804836207849005 0.792032648674067 0.727272727272727 17.5 17 5 abnormal oogenesis 0.0161937898302885 0.0804836207849005 0.792032648674067 0.727272727272727 17.5 17 5 increased skin papilloma incidence 0.0161937898302885 0.0804836207849005 0.792032648674067 0.727272727272727 17.5 17 5 abnormal female reproductive system physiology 0.0161937898302885 0.0804836207849005 0.792032648674067 0.727272727272727 17.5 17 5 increased bone volume 0.0161937898302885 0.0804836207849005 0.792032648674067 0.727272727272727 17.5 17 5 abnormal stomach epithelium morphology 0.0880613051109129 0.280393779260648 0.792032648674067 0.727272727272727 17.5 17 5 abnormal large intestine morphology 0.0880613051109129 0.280393779260648 0.792032648674067 0.727272727272727 17.5 17 5 abnormal sebaceous gland morphology 0.0880613051109129 0.280393779260648 0.792032648674067 0.727272727272727 17.5 17 5 abnormal glossopharyngeal ganglion morphology 0.0880613051109129 0.280393779260648 0.792032648674067 0.727272727272727 17.5 17 5 abnormal food preference 0.0880613051109129 0.280393779260648 0.792032648674067 0.727272727272727 17.5 17 5 abnormal hypothalamus secretion 0.0880613051109129 0.280393779260648 0.792032648674067 0.727272727272727 17.5 17 5 fatigue 0.0880613051109129 0.280393779260648 0.792032648674067 0.727272727272727 17.5 17 5 abnormal spinal cord ventral horn morphology 0.0880613051109129 0.280393779260648 0.792032648674067 0.727272727272727 17.5 17 5 abnormal platelet aggregation 0.0880613051109129 0.280393779260648 0.792032648674067 0.727272727272727 17.5 17 5 abnormal superovulation 0.0880613051109129 0.280393779260648 0.792032648674067 0.727272727272727 17.5 17 5 common atrioventricular valve 0.0880613051109129 0.280393779260648 0.792032648674067 0.727272727272727 17.5 17 5 abnormal dendritic cell chemotaxis 0.0880613051109129 0.280393779260648 0.792032648674067 0.727272727272727 17.5 17 5 chylous ascites 0.0880613051109129 0.280393779260648 0.792032648674067 0.727272727272727 17.5 17 5 hypolactation 0.0880613051109129 0.280393779260648 0.792032648674067 0.727272727272727 17.5 17 5 prenatal lethality 6.73171251778508e-05 0.000820839945489725 0.790435808656579 0.725806451612903 17.5 17 5 increased eosinophil cell number 6.73171251778508e-05 0.000820839945489725 0.790435808656579 0.725806451612903 17.5 17 5 perinatal lethality, incomplete penetrance 3.38049175417185e-14 2.36872485591619e-12 0.790280364053107 0.725663716814159 17.5 17 5 abnormal bone structure 2.58043331676774e-12 1.28376557509195e-10 0.789980750620508 0.725388601036269 17.5 17 5 glomerulosclerosis 0.000127784875855881 0.00146144771812186 0.788618714843576 0.724137931034483 17.5 17 5 abnormal outer ear morphology 0.00648039578577054 0.0387965933022965 0.788618714843576 0.724137931034483 17.5 17 5 increased susceptibility to induced arthritis 0.00648039578577054 0.0387965933022965 0.788618714843576 0.724137931034483 17.5 17 5 decreased bone strength 0.00648039578577054 0.0387965933022965 0.788618714843576 0.724137931034483 17.5 17 5 abnormal blood vessel morphology 1.57652818374454e-09 5.12629262361378e-08 0.788618714843576 0.724137931034483 17.5 17 5 hepatic necrosis 0.000575343708247972 0.0052042453609703 0.787819709053461 0.723404255319149 17.5 17 5 abnormal maxilla morphology 0.000242891444063997 0.00248128323248129 0.786532421947164 0.722222222222222 17.5 17 5 abnormal small intestine morphology 0.000242891444063997 0.00248128323248129 0.786532421947164 0.722222222222222 17.5 17 5 abnormal osteoblast physiology 0.000242891444063997 0.00248128323248129 0.786532421947164 0.722222222222222 17.5 17 5 axon degeneration 0.000242891444063997 0.00248128323248129 0.786532421947164 0.722222222222222 17.5 17 5 cortical renal glomerulopathies 0.0325069248767842 0.136820601744502 0.786532421947164 0.722222222222222 17.5 17 5 abnormal radius morphology 0.0325069248767842 0.136820601744502 0.786532421947164 0.722222222222222 17.5 17 5 abnormal mammary gland morphology 0.0325069248767842 0.136820601744502 0.786532421947164 0.722222222222222 17.5 17 5 abnormal iron level 0.0325069248767842 0.136820601744502 0.786532421947164 0.722222222222222 17.5 17 5 abnormal bile duct morphology 0.0325069248767842 0.136820601744502 0.786532421947164 0.722222222222222 17.5 17 5 abnormal white adipose tissue morphology 0.0325069248767842 0.136820601744502 0.786532421947164 0.722222222222222 17.5 17 5 abnormal body wall morphology 0.0325069248767842 0.136820601744502 0.786532421947164 0.722222222222222 17.5 17 5 abnormal glycogen homeostasis 0.0325069248767842 0.136820601744502 0.786532421947164 0.722222222222222 17.5 17 5 decreased lactate dehydrogenase level 0.0325069248767842 0.136820601744502 0.786532421947164 0.722222222222222 17.5 17 5 thin ventricular wall 2.30686365051437e-06 4.12829016593849e-05 0.786532421947164 0.722222222222222 17.5 17 5 abnormal testis morphology 1.00752091349042e-07 2.34225072178263e-06 0.786006313303721 0.721739130434783 17.5 17 5 hydroencephaly 1.00752091349042e-07 2.34225072178263e-06 0.786006313303721 0.721739130434783 17.5 17 5 abnormal skeleton morphology 1.00752091349042e-07 2.34225072178263e-06 0.786006313303721 0.721739130434783 17.5 17 5 decreased total body fat amount 1.20994214081217e-19 1.62688166230825e-17 0.785807841180746 0.721556886227545 17.5 17 5 abnormal visceral yolk sac morphology 1.00444398314401e-05 0.000158638375115602 0.785766567592785 0.721518987341772 17.5 17 5 abnormal organ of Corti morphology 0.00110155130520348 0.00899871550638309 0.785125387203073 0.720930232558139 17.5 17 5 delayed endochondral bone ossification 0.00110155130520348 0.00899871550638309 0.785125387203073 0.720930232558139 17.5 17 5 kidney failure 0.00110155130520348 0.00899871550638309 0.785125387203073 0.720930232558139 17.5 17 5 increased circulating chloride level 0.000462374289023682 0.00432389490205417 0.784112322187327 0.72 17.5 17 5 mandible hypoplasia 0.0127251041240117 0.067205300442631 0.784112322187327 0.72 17.5 17 5 abnormal cochlear outer hair cell morphology 0.0127251041240117 0.067205300442631 0.784112322187327 0.72 17.5 17 5 abnormal preimplantation embryo development 0.0127251041240117 0.067205300442631 0.784112322187327 0.72 17.5 17 5 limb grasping 3.14942736550526e-11 1.36246966464249e-09 0.783872971661629 0.71978021978022 17.5 17 5 double outlet right ventricle 3.52186156656692e-07 7.51985463247658e-06 0.78370520260156 0.719626168224299 17.5 17 5 anophthalmia 3.51153200932022e-06 6.06592768971114e-05 0.783133405430539 0.719101123595506 17.5 17 5 increased startle reflex 3.51153200932022e-06 6.06592768971114e-05 0.783133405430539 0.719101123595506 17.5 17 5 postnatal growth retardation 4.04266980648826e-34 2.2346980319199e-31 0.782973451712109 0.718954248366013 17.5 17 5 decreased body weight 2.4902500517089e-68 4.12966466908393e-65 0.782915956231737 0.718901453957997 17.5 17 5 abnormal lumbar vertebrae morphology 0.00513764383396683 0.0323541494607405 0.782751016072418 0.71875 17.5 17 5 absent gastric milk in neonates 1.52874341102877e-05 0.000231874953349638 0.781878383947477 0.717948717948718 17.5 17 5 abnormal heart looping 0.00211443851359545 0.0153119819579875 0.781878383947477 0.717948717948718 17.5 17 5 abnormal response to injury 0.00211443851359545 0.0153119819579875 0.781878383947477 0.717948717948718 17.5 17 5 atrial septal defect 0.000881666351612013 0.00746843188109795 0.781271335512735 0.717391304347826 17.5 17 5 increased bone mineral density 2.31868863506748e-07 5.03732574648939e-06 0.780642798637825 0.716814159292035 17.5 17 5 epidermal hyperplasia 0.000157348193947452 0.00173187447984198 0.780482172547571 0.716666666666667 17.5 17 5 increased erythrocyte cell number 0.000157348193947452 0.00173187447984198 0.780482172547571 0.716666666666667 17.5 17 5 decreased white adipose tissue amount 6.7084685962169e-05 0.000820839945489725 0.780211265858037 0.716417910447761 17.5 17 5 decreased bone mineral content 2.65694737535411e-12 1.29591305807713e-10 0.780133119697594 0.716346153846154 17.5 17 5 abnormal glucose homeostasis 8.81265009533523e-11 3.5357205019591e-09 0.777889208519173 0.714285714285714 17.5 17 5 abnormal brain morphology 1.05098512742681e-09 3.55690544826422e-08 0.777889208519173 0.714285714285714 17.5 17 5 decreased inflammatory response 9.9657186411297e-06 0.00015789633834274 0.777889208519173 0.714285714285714 17.5 17 5 abnormal respiratory system physiology 0.000705006750396276 0.00606818093982954 0.777889208519173 0.714285714285714 17.5 17 5 skin edema 0.0016843661040746 0.0128523333861521 0.777889208519173 0.714285714285714 17.5 17 5 abnormal artery morphology 0.0040707978246978 0.0264331329330286 0.777889208519173 0.714285714285714 17.5 17 5 abnormal circulating cholesterol level 0.010001296626077 0.0558433790288808 0.777889208519173 0.714285714285714 17.5 17 5 reddish skin 0.010001296626077 0.0558433790288808 0.777889208519173 0.714285714285714 17.5 17 5 abnormal somite shape 0.010001296626077 0.0558433790288808 0.777889208519173 0.714285714285714 17.5 17 5 increased triglyceride level 0.010001296626077 0.0558433790288808 0.777889208519173 0.714285714285714 17.5 17 5 prolonged QRS complex duration 0.010001296626077 0.0558433790288808 0.777889208519173 0.714285714285714 17.5 17 5 abnormal salivary gland morphology 0.0252015009782939 0.113361182067823 0.777889208519173 0.714285714285714 17.5 17 5 abnormal eye pigmentation 0.0252015009782939 0.113361182067823 0.777889208519173 0.714285714285714 17.5 17 5 left pulmonary isomerism 0.0252015009782939 0.113361182067823 0.777889208519173 0.714285714285714 17.5 17 5 abnormal erythrocyte physiology 0.0252015009782939 0.113361182067823 0.777889208519173 0.714285714285714 17.5 17 5 increased acute inflammation 0.0252015009782939 0.113361182067823 0.777889208519173 0.714285714285714 17.5 17 5 increased keratinocyte proliferation 0.0252015009782939 0.113361182067823 0.777889208519173 0.714285714285714 17.5 17 5 embryonic lethality at implantation, complete penetrance 0.0252015009782939 0.113361182067823 0.777889208519173 0.714285714285714 17.5 17 5 abnormal blood flow velocity 0.0663766228687505 0.226621043588528 0.777889208519173 0.714285714285714 17.5 17 5 abnormal kidney blood vessel morphology 0.0663766228687505 0.226621043588528 0.777889208519173 0.714285714285714 17.5 17 5 absent otoliths 0.0663766228687505 0.226621043588528 0.777889208519173 0.714285714285714 17.5 17 5 amyloid beta deposits 0.0663766228687505 0.226621043588528 0.777889208519173 0.714285714285714 17.5 17 5 absent olfactory bulb 0.0663766228687505 0.226621043588528 0.777889208519173 0.714285714285714 17.5 17 5 decreased CNS synapse formation 0.0663766228687505 0.226621043588528 0.777889208519173 0.714285714285714 17.5 17 5 abnormal viscerocranium morphology 0.0663766228687505 0.226621043588528 0.777889208519173 0.714285714285714 17.5 17 5 increased pulmonary respiratory rate 0.0663766228687505 0.226621043588528 0.777889208519173 0.714285714285714 17.5 17 5 pulmonary alveolar hemorrhage 0.0663766228687505 0.226621043588528 0.777889208519173 0.714285714285714 17.5 17 5 asymmetric rib joints 0.193080913206918 0.464945567862739 0.777889208519173 0.714285714285714 17.5 17 5 failure of atrioventricular cushion closure 0.193080913206918 0.464945567862739 0.777889208519173 0.714285714285714 17.5 17 5 abnormal foot pad morphology 0.193080913206918 0.464945567862739 0.777889208519173 0.714285714285714 17.5 17 5 mammary gland hyperplasia 0.193080913206918 0.464945567862739 0.777889208519173 0.714285714285714 17.5 17 5 prostate gland epithelial hyperplasia 0.193080913206918 0.464945567862739 0.777889208519173 0.714285714285714 17.5 17 5 absent epidermis stratum corneum 0.193080913206918 0.464945567862739 0.777889208519173 0.714285714285714 17.5 17 5 retina hyperplasia 0.193080913206918 0.464945567862739 0.777889208519173 0.714285714285714 17.5 17 5 excessive tearing 0.193080913206918 0.464945567862739 0.777889208519173 0.714285714285714 17.5 17 5 abnormal axial mesoderm 0.193080913206918 0.464945567862739 0.777889208519173 0.714285714285714 17.5 17 5 absent amniotic folds 0.193080913206918 0.464945567862739 0.777889208519173 0.714285714285714 17.5 17 5 abnormal lymph node primary follicle morphology 0.193080913206918 0.464945567862739 0.777889208519173 0.714285714285714 17.5 17 5 abnormal inhibitory postsynaptic potential 0.193080913206918 0.464945567862739 0.777889208519173 0.714285714285714 17.5 17 5 decreased urine calcium level 0.193080913206918 0.464945567862739 0.777889208519173 0.714285714285714 17.5 17 5 anuria 0.193080913206918 0.464945567862739 0.777889208519173 0.714285714285714 17.5 17 5 abnormal hard palate morphology 0.193080913206918 0.464945567862739 0.777889208519173 0.714285714285714 17.5 17 5 increased ectoderm apoptosis 0.193080913206918 0.464945567862739 0.777889208519173 0.714285714285714 17.5 17 5 renal necrosis 0.193080913206918 0.464945567862739 0.777889208519173 0.714285714285714 17.5 17 5 abnormal organ of Corti supporting cell morphology 0.193080913206918 0.464945567862739 0.777889208519173 0.714285714285714 17.5 17 5 absent deltoid tuberosity 0.193080913206918 0.464945567862739 0.777889208519173 0.714285714285714 17.5 17 5 absent endocochlear potential 0.193080913206918 0.464945567862739 0.777889208519173 0.714285714285714 17.5 17 5 abnormal talus morphology 0.193080913206918 0.464945567862739 0.777889208519173 0.714285714285714 17.5 17 5 abnormal renal/urinary system physiology 0.193080913206918 0.464945567862739 0.777889208519173 0.714285714285714 17.5 17 5 retinal pigment epithelium atrophy 0.193080913206918 0.464945567862739 0.777889208519173 0.714285714285714 17.5 17 5 abnormal cerebellum white matter morphology 0.193080913206918 0.464945567862739 0.777889208519173 0.714285714285714 17.5 17 5 increased oligodendrocyte number 0.193080913206918 0.464945567862739 0.777889208519173 0.714285714285714 17.5 17 5 decreased skeletal muscle glycogen level 0.193080913206918 0.464945567862739 0.777889208519173 0.714285714285714 17.5 17 5 coronary fistula 0.193080913206918 0.464945567862739 0.777889208519173 0.714285714285714 17.5 17 5 long stride length 0.193080913206918 0.464945567862739 0.777889208519173 0.714285714285714 17.5 17 5 heart block 0.193080913206918 0.464945567862739 0.777889208519173 0.714285714285714 17.5 17 5 abnormal conotruncal ridge morphology 0.193080913206918 0.464945567862739 0.777889208519173 0.714285714285714 17.5 17 5 thick mitral valve cusps 0.193080913206918 0.464945567862739 0.777889208519173 0.714285714285714 17.5 17 5 increased right ventricle systolic pressure 0.193080913206918 0.464945567862739 0.777889208519173 0.714285714285714 17.5 17 5 abnormal tricarboxylic acid cycle 0.193080913206918 0.464945567862739 0.777889208519173 0.714285714285714 17.5 17 5 small lung lobe 0.193080913206918 0.464945567862739 0.777889208519173 0.714285714285714 17.5 17 5 abnormal brain ependyma motile cilium physiology 0.193080913206918 0.464945567862739 0.777889208519173 0.714285714285714 17.5 17 5 increased circulating lactate dehydrogenase level 0.193080913206918 0.464945567862739 0.777889208519173 0.714285714285714 17.5 17 5 small tail bud 0.193080913206918 0.464945567862739 0.777889208519173 0.714285714285714 17.5 17 5 absent heart tube 0.193080913206918 0.464945567862739 0.777889208519173 0.714285714285714 17.5 17 5 decreased volumetric bone mineral density 0.193080913206918 0.464945567862739 0.777889208519173 0.714285714285714 17.5 17 5 embryo tumor 0.193080913206918 0.464945567862739 0.777889208519173 0.714285714285714 17.5 17 5 short snout 6.51780758309805e-07 1.32351398881277e-05 0.776448672947842 0.712962962962963 17.5 17 5 short limbs 8.03676836898861e-06 0.000130663145868361 0.776100957465106 0.71264367816092 17.5 17 5 abnormal posture 1.86552329442275e-05 0.000274585159460154 0.775944485497876 0.7125 17.5 17 5 decreased percent body fat/body weight 4.34397961437053e-05 0.000559878201593093 0.775758005208162 0.712328767123288 17.5 17 5 reduced fertility 1.89388100654845e-08 5.41497586642445e-07 0.775650678422715 0.712230215827338 17.5 17 5 increased hemoglobin content 0.000238463480768477 0.00247157461838161 0.775252295947922 0.711864406779661 17.5 17 5 cachexia 1.21329397668374e-06 2.31269637318069e-05 0.774897326947946 0.711538461538462 17.5 17 5 abnormal female meiosis 0.000563347592933454 0.00511433261832835 0.774897326947946 0.711538461538462 17.5 17 5 abnormal myocardial fiber morphology 2.80036819972259e-06 4.92290876099642e-05 0.774681417968579 0.711340206185567 17.5 17 5 decreased circulating HDL cholesterol level 8.0551307249178e-08 1.95484270031542e-06 0.77424285285424 0.7109375 17.5 17 5 abnormal lens morphology 8.0551307249178e-08 1.95484270031542e-06 0.77424285285424 0.7109375 17.5 17 5 short tail 1.50168304170866e-05 0.000228467068272189 0.774140344863659 0.710843373493976 17.5 17 5 abnormal bone mineralization 1.84960990722879e-07 4.10795057520681e-06 0.774031906658748 0.710743801652893 17.5 17 5 prenatal lethality, incomplete penetrance 1.60952394739512e-16 1.53988108428668e-14 0.773795054790125 0.710526315789474 17.5 17 5 decreased bone mineral density 1.21978828530348e-14 8.66920959912117e-13 0.773795054790125 0.710526315789474 17.5 17 5 abnormal axial skeleton morphology 3.49186913632054e-05 0.000473352832512117 0.773795054790125 0.710526315789474 17.5 17 5 persistence of hyaloid vascular system 0.00322474970980993 0.0217977307150875 0.773795054790125 0.710526315789474 17.5 17 5 infertility 9.79012280773708e-07 1.93277226065444e-05 0.773527212957384 0.710280373831776 17.5 17 5 small testis 4.3374167037749e-15 3.42518223829843e-13 0.773379705861091 0.710144927536232 17.5 17 5 abnormal podocyte morphology 0.00786465642650537 0.0453379672327511 0.772870568464211 0.709677419354839 17.5 17 5 preaxial polydactyly 0.00786465642650537 0.0453379672327511 0.772870568464211 0.709677419354839 17.5 17 5 increased oxygen consumption 1.20809521088973e-05 0.000187235940005495 0.772462074506249 0.709302325581395 17.5 17 5 abnormal learning/memory/conditioning 0.000449916761217423 0.00425539142025985 0.772231832457216 0.709090909090909 17.5 17 5 retinal degeneration 4.19945759473437e-06 7.10622501149778e-05 0.77140679844818 0.708333333333333 17.5 17 5 abnormal osteoclast morphology 0.00106729240425076 0.00879102601183362 0.77140679844818 0.708333333333333 17.5 17 5 abnormal digestive system morphology 0.0195862076793236 0.0954372019634035 0.77140679844818 0.708333333333333 17.5 17 5 abnormal startle reflex 0.0195862076793236 0.0954372019634035 0.77140679844818 0.708333333333333 17.5 17 5 abnormal vasodilation 0.0195862076793236 0.0954372019634035 0.77140679844818 0.708333333333333 17.5 17 5 abnormal primitive streak formation 0.0195862076793236 0.0954372019634035 0.77140679844818 0.708333333333333 17.5 17 5 abnormal impulse conducting system conduction 0.0195862076793236 0.0954372019634035 0.77140679844818 0.708333333333333 17.5 17 5 prolonged QT interval 0.0195862076793236 0.0954372019634035 0.77140679844818 0.708333333333333 17.5 17 5 decreased fatty acid level 0.0195862076793236 0.0954372019634035 0.77140679844818 0.708333333333333 17.5 17 5 abnormal inner cell mass apoptosis 0.0195862076793236 0.0954372019634035 0.77140679844818 0.708333333333333 17.5 17 5 abnormal lipid homeostasis 9.72853260393424e-08 2.30473570021776e-06 0.770708692748227 0.707692307692308 17.5 17 5 hemopericardium 0.00255450495202344 0.0178995241356572 0.77030004550923 0.707317073170732 17.5 17 5 increased bone trabecula number 0.00255450495202344 0.0178995241356572 0.77030004550923 0.707317073170732 17.5 17 5 abnormal enzyme/coenzyme activity 5.2809335460488e-09 1.62176817232054e-07 0.769961675183946 0.707006369426752 17.5 17 5 abnormal locomotor behavior 7.80737602432416e-06 0.000127349822036107 0.769433891035269 0.706521739130435 17.5 17 5 abnormal vertebrae morphology 1.17965278499381e-06 2.26593536885877e-05 0.769325290627219 0.706422018348624 17.5 17 5 abnormal renal glomerulus morphology 1.17965278499381e-06 2.26593536885877e-05 0.769325290627219 0.706422018348624 17.5 17 5 increased insulin sensitivity 2.76273201053055e-08 7.67854287842987e-07 0.769185553039239 0.706293706293706 17.5 17 5 decreased circulating glucose level 9.40323895677169e-15 6.77987156665785e-13 0.768967181754796 0.706093189964158 17.5 17 5 decreased susceptibility to injury 0.000122285060110625 0.00141152708596371 0.768737570771889 0.705882352941177 17.5 17 5 small lung 0.000849260632933616 0.0072539694361601 0.768737570771889 0.705882352941177 17.5 17 5 impaired synaptic plasticity 0.00618872696461837 0.0373198989684562 0.768737570771889 0.705882352941177 17.5 17 5 abnormal skin physiology 0.00618872696461837 0.0373198989684562 0.768737570771889 0.705882352941177 17.5 17 5 abnormal adipose tissue morphology 0.0504786686611309 0.186414718074837 0.768737570771889 0.705882352941177 17.5 17 5 increased incidence of corneal inflammation 0.0504786686611309 0.186414718074837 0.768737570771889 0.705882352941177 17.5 17 5 hyperlipidemia 0.0504786686611309 0.186414718074837 0.768737570771889 0.705882352941177 17.5 17 5 abnormal glutamate-mediated receptor currents 0.0504786686611309 0.186414718074837 0.768737570771889 0.705882352941177 17.5 17 5 decreased vasoconstriction 0.0504786686611309 0.186414718074837 0.768737570771889 0.705882352941177 17.5 17 5 absence seizures 0.0504786686611309 0.186414718074837 0.768737570771889 0.705882352941177 17.5 17 5 abnormal ectoplacental cone morphology 0.0504786686611309 0.186414718074837 0.768737570771889 0.705882352941177 17.5 17 5 abnormal melanosome morphology 0.0504786686611309 0.186414718074837 0.768737570771889 0.705882352941177 17.5 17 5 enhanced behavioral response to cocaine 0.0504786686611309 0.186414718074837 0.768737570771889 0.705882352941177 17.5 17 5 abnormal circulating chemokine level 0.0504786686611309 0.186414718074837 0.768737570771889 0.705882352941177 17.5 17 5 abnormal heart ventricle morphology 4.19843476595388e-05 0.000543937837516161 0.767916269948415 0.705128205128205 17.5 17 5 reduced male fertility 3.68495235474125e-12 1.74596552046073e-10 0.767608734397775 0.704845814977974 17.5 17 5 insulin resistance 1.16764010746859e-07 2.67696291919641e-06 0.767281628403003 0.704545454545455 17.5 17 5 omphalocele 0.00202381619662386 0.01478991175956 0.767281628403003 0.704545454545455 17.5 17 5 cochlear hair cell degeneration 0.00202381619662386 0.01478991175956 0.767281628403003 0.704545454545455 17.5 17 5 embryonic lethality, incomplete penetrance 0.00202381619662386 0.01478991175956 0.767281628403003 0.704545454545455 17.5 17 5 azoospermia 6.33517008921761e-09 1.92179702401571e-07 0.767125961608845 0.70440251572327 17.5 17 5 polydactyly 5.03750527228489e-06 8.40992910389844e-05 0.766776505540328 0.704081632653061 17.5 17 5 rectal prolapse 0.0152569094005629 0.0771373214103661 0.766364923948519 0.703703703703704 17.5 17 5 thin epidermis 0.0152569094005629 0.0771373214103661 0.766364923948519 0.703703703703704 17.5 17 5 increased blood urea nitrogen level 3.30844138832677e-08 8.99426005842933e-07 0.766086751562331 0.703448275862069 17.5 17 5 weight loss 1.45368590002671e-09 4.75795220567953e-08 0.765442981182867 0.702857142857143 17.5 17 5 abnormal intestine morphology 7.82100038168246e-05 0.000937577756599283 0.765274788921565 0.702702702702703 17.5 17 5 skin inflammation 0.00487360222300266 0.0307692526135003 0.765274788921565 0.702702702702703 17.5 17 5 impaired coordination 2.16628985586796e-17 2.34288957237893e-15 0.764849447220297 0.702312138728324 17.5 17 5 increased respiratory quotient 0.00160371258239868 0.01229348243056 0.764648541140124 0.702127659574468 17.5 17 5 abnormal circulating amino acid level 0.000537597222685672 0.0048995032225062 0.764242029422346 0.701754385964912 17.5 17 5 abnormal retinal pigmentation 2.15692293448369e-05 0.000309241832825832 0.763583200086637 0.701149425287356 17.5 17 5 anencephaly 0.0386458518940246 0.158895134853531 0.76233142434879 0.7 17.5 17 5 abnormal hair texture 0.0386458518940246 0.158895134853531 0.76233142434879 0.7 17.5 17 5 abnormal optic stalk morphology 0.0386458518940246 0.158895134853531 0.76233142434879 0.7 17.5 17 5 abnormal induced retinal neovascularization 0.0386458518940246 0.158895134853531 0.76233142434879 0.7 17.5 17 5 abnormal auchene hair morphology 0.139104048329975 0.364424771164627 0.76233142434879 0.7 17.5 17 5 retarded hair growth 0.139104048329975 0.364424771164627 0.76233142434879 0.7 17.5 17 5 increased cranium width 0.139104048329975 0.364424771164627 0.76233142434879 0.7 17.5 17 5 abnormal prostate gland epithelium morphology 0.139104048329975 0.364424771164627 0.76233142434879 0.7 17.5 17 5 absent trophoblast giant cells 0.139104048329975 0.364424771164627 0.76233142434879 0.7 17.5 17 5 rhinitis 0.139104048329975 0.364424771164627 0.76233142434879 0.7 17.5 17 5 abnormal mammary gland physiology 0.139104048329975 0.364424771164627 0.76233142434879 0.7 17.5 17 5 abnormal airway responsiveness 0.139104048329975 0.364424771164627 0.76233142434879 0.7 17.5 17 5 abnormal tibialis anterior morphology 0.139104048329975 0.364424771164627 0.76233142434879 0.7 17.5 17 5 acrania 0.139104048329975 0.364424771164627 0.76233142434879 0.7 17.5 17 5 peritoneal inflammation 0.139104048329975 0.364424771164627 0.76233142434879 0.7 17.5 17 5 lymphedema 0.139104048329975 0.364424771164627 0.76233142434879 0.7 17.5 17 5 absent seminal vesicle 0.139104048329975 0.364424771164627 0.76233142434879 0.7 17.5 17 5 abnormal glial cell physiology 0.139104048329975 0.364424771164627 0.76233142434879 0.7 17.5 17 5 abnormal submandibular gland morphology 0.139104048329975 0.364424771164627 0.76233142434879 0.7 17.5 17 5 increased atrioventricular cushion size 0.139104048329975 0.364424771164627 0.76233142434879 0.7 17.5 17 5 abnormal ear physiology 0.139104048329975 0.364424771164627 0.76233142434879 0.7 17.5 17 5 abnormal reproductive system development 0.139104048329975 0.364424771164627 0.76233142434879 0.7 17.5 17 5 abnormal respiratory conducting tube morphology 0.139104048329975 0.364424771164627 0.76233142434879 0.7 17.5 17 5 vascular smooth muscle hyperplasia 0.139104048329975 0.364424771164627 0.76233142434879 0.7 17.5 17 5 protruding tongue 0.139104048329975 0.364424771164627 0.76233142434879 0.7 17.5 17 5 abnormal cerebellar granule cell migration 0.139104048329975 0.364424771164627 0.76233142434879 0.7 17.5 17 5 increased serotonin level 0.139104048329975 0.364424771164627 0.76233142434879 0.7 17.5 17 5 aorta stenosis 0.139104048329975 0.364424771164627 0.76233142434879 0.7 17.5 17 5 increased compact bone area 0.139104048329975 0.364424771164627 0.76233142434879 0.7 17.5 17 5 abnormal adaptive thermogenesis 0.139104048329975 0.364424771164627 0.76233142434879 0.7 17.5 17 5 short stride length 0.00127114916026566 0.0101183473157147 0.76233142434879 0.7 17.5 17 5 kidney inflammation 0.00127114916026566 0.0101183473157147 0.76233142434879 0.7 17.5 17 5 abnormal response to new environment 0.0119091192328176 0.0640546125437572 0.76233142434879 0.7 17.5 17 5 abnormal lactation 0.0119091192328176 0.0640546125437572 0.76233142434879 0.7 17.5 17 5 hypoglycemia 1.38215290152663e-05 0.00021222872484861 0.761160408335965 0.698924731182796 17.5 17 5 decreased grip strength 3.22016832351952e-11 1.36925960765039e-09 0.760839582031082 0.698630136986301 17.5 17 5 gliosis 0.000340343518514752 0.00334626285496223 0.760602781663192 0.698412698412698 17.5 17 5 enlarged kidney 0.00100784774669315 0.00844114905689968 0.760276622665909 0.69811320754717 17.5 17 5 increased circulating creatinine level 3.19254619741376e-05 0.000441192148114818 0.759798761809425 0.697674418604651 17.5 17 5 abnormal tooth development 0.00931316260778458 0.0527710523618773 0.759031288312648 0.696969696969697 17.5 17 5 abnormal epidermis stratum basale morphology 0.00931316260778458 0.0527710523618773 0.759031288312648 0.696969696969697 17.5 17 5 cardiovascular system phenotype 0.00931316260778458 0.0527710523618773 0.759031288312648 0.696969696969697 17.5 17 5 abnormal neuron morphology 8.85201820219045e-06 0.000142983086220446 0.759031288312648 0.696969696969697 17.5 17 5 abnormal myocardium layer morphology 7.39103861757567e-05 0.000890324869792711 0.758195810835144 0.69620253164557 17.5 17 5 abnormal pulmonary artery morphology 0.029741681335363 0.126573879079068 0.757596446557804 0.695652173913043 17.5 17 5 abnormal cranial nerve morphology 0.029741681335363 0.126573879079068 0.757596446557804 0.695652173913043 17.5 17 5 abnormal circulating insulin level 0.029741681335363 0.126573879079068 0.757596446557804 0.695652173913043 17.5 17 5 failure of embryo implantation 0.029741681335363 0.126573879079068 0.757596446557804 0.695652173913043 17.5 17 5 conjunctivitis 0.029741681335363 0.126573879079068 0.757596446557804 0.695652173913043 17.5 17 5 abnormal corneal stroma morphology 0.029741681335363 0.126573879079068 0.757596446557804 0.695652173913043 17.5 17 5 abnormal lens development 0.029741681335363 0.126573879079068 0.757596446557804 0.695652173913043 17.5 17 5 abnormal basicranium morphology 0.029741681335363 0.126573879079068 0.757596446557804 0.695652173913043 17.5 17 5 abnormal nervous system physiology 1.97858847608044e-06 3.64573246981489e-05 0.757596446557804 0.695652173913043 17.5 17 5 perimembraneous ventricular septal defect 0.000215548114608402 0.00225758288458273 0.757596446557804 0.695652173913043 17.5 17 5 female infertility 5.70740363856214e-13 3.12025638481831e-11 0.757418439873932 0.695488721804511 17.5 17 5 increased circulating HDL cholesterol level 5.66713341416613e-06 9.39799624515884e-05 0.757145496291995 0.695238095238095 17.5 17 5 abnormal excitatory postsynaptic potential 5.8960426884692e-05 0.000742602844940108 0.75701901024183 0.695121951219512 17.5 17 5 cochlear outer hair cell degeneration 0.000171569746508749 0.00186774505225608 0.756281174949196 0.694444444444444 17.5 17 5 renal hypoplasia 0.00729516865871325 0.0428494263011787 0.756281174949196 0.694444444444444 17.5 17 5 abnormal cranium morphology 3.56654401264379e-07 7.58271643713798e-06 0.755829663799973 0.694029850746269 17.5 17 5 abnormal long bone hypertrophic chondrocyte zone 0.00188847321965424 0.0141706700871491 0.755663802561483 0.693877551020408 17.5 17 5 decreased body size 2.66299723695394e-35 1.65605140673073e-32 0.754689004054567 0.692982456140351 17.5 17 5 abnormal snout morphology 0.00149256497293396 0.0114768326744149 0.753954155949353 0.692307692307692 17.5 17 5 abnormal skin condition 0.00149256497293396 0.0114768326744149 0.753954155949353 0.692307692307692 17.5 17 5 abnormal brain wave pattern 0.00149256497293396 0.0114768326744149 0.753954155949353 0.692307692307692 17.5 17 5 abnormal nasal bone morphology 0.0229854383036953 0.109533099196249 0.753954155949353 0.692307692307692 17.5 17 5 absent myocardial trabeculae 0.10270305360659 0.306024780249694 0.753954155949353 0.692307692307692 17.5 17 5 short hair 0.10270305360659 0.306024780249694 0.753954155949353 0.692307692307692 17.5 17 5 tight skin 0.10270305360659 0.306024780249694 0.753954155949353 0.692307692307692 17.5 17 5 excessive scratching 0.10270305360659 0.306024780249694 0.753954155949353 0.692307692307692 17.5 17 5 abnormal digestion 0.10270305360659 0.306024780249694 0.753954155949353 0.692307692307692 17.5 17 5 abnormal pulmonary alveolus epithelial cell morphology 0.10270305360659 0.306024780249694 0.753954155949353 0.692307692307692 17.5 17 5 abnormal bile duct development 0.10270305360659 0.306024780249694 0.753954155949353 0.692307692307692 17.5 17 5 abnormal coping response 0.10270305360659 0.306024780249694 0.753954155949353 0.692307692307692 17.5 17 5 tracheoesophageal fistula 0.10270305360659 0.306024780249694 0.753954155949353 0.692307692307692 17.5 17 5 small otic vesicle 0.10270305360659 0.306024780249694 0.753954155949353 0.692307692307692 17.5 17 5 small interparietal bone 0.10270305360659 0.306024780249694 0.753954155949353 0.692307692307692 17.5 17 5 decreased endocochlear potential 0.10270305360659 0.306024780249694 0.753954155949353 0.692307692307692 17.5 17 5 abnormal vertebral arch development 0.10270305360659 0.306024780249694 0.753954155949353 0.692307692307692 17.5 17 5 increased circulating thyroxine level 0.10270305360659 0.306024780249694 0.753954155949353 0.692307692307692 17.5 17 5 empty decidua capsularis 0.10270305360659 0.306024780249694 0.753954155949353 0.692307692307692 17.5 17 5 abnormal aorta tunica media morphology 0.10270305360659 0.306024780249694 0.753954155949353 0.692307692307692 17.5 17 5 postnatal lethality, incomplete penetrance 3.13690956868762e-25 8.21375005485312e-23 0.753511694590227 0.691901408450704 17.5 17 5 abnormal seminiferous tubule morphology 1.46976703405248e-07 3.30863845900953e-06 0.753380370442542 0.691780821917808 17.5 17 5 abnormal ovary morphology 0.000252043145443198 0.00256949723069654 0.751594362034018 0.690140845070423 17.5 17 5 abnormal microglial cell morphology 0.0178255207156468 0.0880429525288252 0.751065442708168 0.689655172413793 17.5 17 5 short sternum 0.0178255207156468 0.0880429525288252 0.751065442708168 0.689655172413793 17.5 17 5 abnormal metabolism 0.00353571463458129 0.0234535737427226 0.750230925549603 0.688888888888889 17.5 17 5 neonatal lethality, incomplete penetrance 5.46216757474683e-12 2.51613737818199e-10 0.749765521749634 0.688461538461538 17.5 17 5 abnormal retinal pigment epithelium morphology 0.00012655487195807 0.00145071541011843 0.748718363199705 0.6875 17.5 17 5 decreased eosinophil cell number 0.000585847641153912 0.00528964068011018 0.748718363199704 0.6875 17.5 17 5 abnormal intestinal epithelium morphology 0.00278383697432409 0.0189720396537841 0.748718363199704 0.6875 17.5 17 5 abnormal lymphatic vessel morphology 0.0138640841300901 0.0716216889179517 0.748718363199704 0.6875 17.5 17 5 neonatal lethality 0.0138640841300901 0.0716216889179517 0.748718363199704 0.6875 17.5 17 5 absent mandible 0.0769848344673273 0.252455310779065 0.748718363199704 0.6875 17.5 17 5 vasculature congestion 0.0769848344673273 0.252455310779065 0.748718363199704 0.6875 17.5 17 5 abnormal mouth morphology 0.0769848344673273 0.252455310779065 0.748718363199704 0.6875 17.5 17 5 disorganized retinal layers 0.0769848344673273 0.252455310779065 0.748718363199704 0.6875 17.5 17 5 reduced male mating frequency 0.0769848344673273 0.252455310779065 0.748718363199704 0.6875 17.5 17 5 paternal imprinting 0.0769848344673273 0.252455310779065 0.748718363199704 0.6875 17.5 17 5 decreased aggression towards mice 0.0769848344673273 0.252455310779065 0.748718363199704 0.6875 17.5 17 5 abnormal molar crown morphology 0.0769848344673273 0.252455310779065 0.748718363199704 0.6875 17.5 17 5 abnormal amnion morphology 0.0769848344673273 0.252455310779065 0.748718363199704 0.6875 17.5 17 5 embryonic lethality between somite formation and embryo turning, incomplete penetrance 0.0769848344673273 0.252455310779065 0.748718363199704 0.6875 17.5 17 5 decreased midbrain size 0.0769848344673273 0.252455310779065 0.748718363199704 0.6875 17.5 17 5 maternal effect 0.000464316078670981 0.00433390711329856 0.747702463113952 0.686567164179104 17.5 17 5 microphthalmia 1.59211759324317e-07 3.56792118305621e-06 0.747383749361559 0.686274509803922 17.5 17 5 abnormal cervical vertebrae morphology 0.0021940303138045 0.0155710425266439 0.747383749361559 0.686274509803922 17.5 17 5 abnormal thrombosis 0.0021940303138045 0.0155710425266439 0.747383749361559 0.686274509803922 17.5 17 5 male infertility 2.5508980360426e-21 4.09377991268127e-19 0.746959220108868 0.685884691848907 17.5 17 5 thick pulmonary interalveolar septum 0.0108096632698997 0.059753416408612 0.746773640178407 0.685714285714286 17.5 17 5 impaired glucose tolerance 3.21177037152339e-11 1.36925960765039e-09 0.746522708175658 0.685483870967742 17.5 17 5 abnormal muscle physiology 6.36950067322688e-05 0.000794192126548966 0.746424027050982 0.685393258426966 17.5 17 5 no abnormal phenotype detected 2.99915164731963e-71 7.46038972270759e-68 0.746325289049577 0.685302593659942 17.5 17 5 increased sensitivity to induced morbidity/mortality 1.18450895831501e-08 3.48694205184449e-07 0.745759002080338 0.684782608695652 17.5 17 5 abnormal cardiovascular system physiology 1.27699903917192e-06 2.41561605318642e-05 0.745135978686787 0.684210526315789 17.5 17 5 alopecia 4.03487189136656e-05 0.000525483970145252 0.745135978686787 0.684210526315789 17.5 17 5 decreased threshold for auditory brainstem response 0.00844611600158686 0.048242740652003 0.745135978686787 0.684210526315789 17.5 17 5 shiny skin 0.0583101001013988 0.202578734639985 0.745135978686787 0.684210526315789 17.5 17 5 stereotypic behavior 0.0583101001013988 0.202578734639985 0.745135978686787 0.684210526315789 17.5 17 5 decreased germ cell number 0.0583101001013988 0.202578734639985 0.745135978686787 0.684210526315789 17.5 17 5 abnormal neural crest cell migration 0.0583101001013988 0.202578734639985 0.745135978686787 0.684210526315789 17.5 17 5 abnormal metatarsal bone morphology 0.0583101001013988 0.202578734639985 0.745135978686787 0.684210526315789 17.5 17 5 abnormal sternebra morphology 0.0583101001013988 0.202578734639985 0.745135978686787 0.684210526315789 17.5 17 5 decreased susceptibility to weight gain 0.0583101001013988 0.202578734639985 0.745135978686787 0.684210526315789 17.5 17 5 thin interventricular septum 0.0583101001013988 0.202578734639985 0.745135978686787 0.684210526315789 17.5 17 5 skin lesions 0.000853619333326095 0.00725941227914072 0.74331635480721 0.682539682539683 17.5 17 5 decreased susceptibility to hepatic steatosis 0.000853619333326095 0.00725941227914072 0.74331635480721 0.682539682539683 17.5 17 5 abnormal lung development 0.000116088810355491 0.00134939680261347 0.743112985079493 0.682352941176471 17.5 17 5 cardiac fibrosis 0.000116088810355491 0.00134939680261347 0.743112985079493 0.682352941176471 17.5 17 5 increased sensitivity to xenobiotic induced morbidity/mortality 1.29321218019017e-05 0.000199186705772325 0.742530608131938 0.681818181818182 17.5 17 5 abnormal amino acid level 0.00518398147998477 0.032481496049023 0.742530608131938 0.681818181818182 17.5 17 5 decreased sensitivity to induced morbidity/mortality 0.00518398147998477 0.032481496049023 0.742530608131938 0.681818181818182 17.5 17 5 abnormal long bone epiphysis morphology 0.0445037391525908 0.174472893840929 0.742530608131938 0.681818181818182 17.5 17 5 testis hypoplasia 0.0445037391525908 0.174472893840929 0.742530608131938 0.681818181818182 17.5 17 5 abnormal chorion morphology 0.0445037391525908 0.174472893840929 0.742530608131938 0.681818181818182 17.5 17 5 parakeratosis 0.0445037391525908 0.174472893840929 0.742530608131938 0.681818181818182 17.5 17 5 abnormal circulating lipid level 0.0445037391525908 0.174472893840929 0.742530608131938 0.681818181818182 17.5 17 5 abnormal limb posture 0.0445037391525908 0.174472893840929 0.742530608131938 0.681818181818182 17.5 17 5 decreased circulating estradiol level 0.0445037391525908 0.174472893840929 0.742530608131938 0.681818181818182 17.5 17 5 abnormal cerebral cortex pyramidal cell morphology 0.0445037391525908 0.174472893840929 0.742530608131938 0.681818181818182 17.5 17 5 increased circulating creatine kinase level 0.0445037391525908 0.174472893840929 0.742530608131938 0.681818181818182 17.5 17 5 abnormal rib morphology 1.46999377828813e-06 2.75970530074846e-05 0.742163926350145 0.681481481481481 17.5 17 5 increased thermal nociceptive threshold 7.33378613695922e-05 0.000885572476489614 0.741986629664442 0.681318681318681 17.5 17 5 abnormal spatial learning 1.35207680918195e-07 3.0714986875252e-06 0.741619527631163 0.680981595092024 17.5 17 5 increased susceptibility to bacterial infection induced morbidity/mortality 0.000423486473607905 0.00402069695839566 0.741155551450212 0.680555555555556 17.5 17 5 decreased respiratory quotient 0.00320028684585497 0.0216618055212633 0.740550526510253 0.68 17.5 17 5 increased liver glycogen level 0.0341660527343614 0.142120495278803 0.740550526510253 0.68 17.5 17 5 abnormal gait 6.23148191612189e-13 3.369741579642e-11 0.740127596455136 0.679611650485437 17.5 17 5 abnormal cornea morphology 0.000266098820697395 0.00270724260320969 0.73999204195029 0.67948717948718 17.5 17 5 abnormal placenta development 0.00251902498144393 0.0177258122810234 0.739728605837101 0.679245283018868 17.5 17 5 abnormal skeleton development 0.000211078579731804 0.00221611995873981 0.739474926616992 0.679012345679012 17.5 17 5 decreased heart weight 0.000211078579731804 0.00221611995873981 0.739474926616992 0.679012345679012 17.5 17 5 short mandible 0.00198485335725516 0.01478991175956 0.738994748093215 0.678571428571429 17.5 17 5 shortened head 0.0263520919244775 0.115976836236329 0.738994748093215 0.678571428571429 17.5 17 5 corneal vascularization 0.0263520919244775 0.115976836236329 0.738994748093215 0.678571428571429 17.5 17 5 increased or absent threshold for auditory brainstem response 4.85205544040283e-12 2.25597904822468e-10 0.73859099936907 0.678200692041522 17.5 17 5 abnormal eyelid morphology 0.0204024911260735 0.0984504300215474 0.737740088079474 0.67741935483871 17.5 17 5 decreased susceptibility to bacterial infection induced morbidity/mortality 0.0204024911260735 0.0984504300215474 0.737740088079474 0.67741935483871 17.5 17 5 abnormal vision 0.0158460734980411 0.0796305208613681 0.736706838656394 0.676470588235294 17.5 17 5 impaired balance 4.21473641876612e-05 0.000544631524243154 0.736706838656394 0.676470588235294 17.5 17 5 abnormal retina morphology 5.35728611352233e-09 1.63512260213335e-07 0.736401784064817 0.676190476190476 17.5 17 5 kidney cysts 0.000483256132572532 0.00450224580439765 0.735841143193813 0.675675675675676 17.5 17 5 abnormal long bone metaphysis morphology 0.0123400987331102 0.0654498840055686 0.735841143193813 0.675675675675676 17.5 17 5 abnormal vocalization 0.0123400987331102 0.0654498840055686 0.735841143193813 0.675675675675676 17.5 17 5 increased circulating phosphate level 0.0123400987331102 0.0654498840055686 0.735841143193813 0.675675675675676 17.5 17 5 abnormal hair follicle development 0.0123400987331102 0.0654498840055686 0.735841143193813 0.675675675675676 17.5 17 5 abnormal lipid level 0.000240461873774249 0.0024768070849418 0.734777276480761 0.674698795180723 17.5 17 5 cardiac hypertrophy 7.57939172596699e-05 0.00091080854677985 0.733438396603792 0.673469387755102 17.5 17 5 decreased kidney weight 0.00363822366265562 0.0241014150755149 0.73301098495076 0.673076923076923 17.5 17 5 reduced female fertility 1.80092903760298e-09 5.81793633900963e-08 0.732288806640463 0.672413793103448 17.5 17 5 thrombocytosis 0.00225393499166531 0.0159280207152484 0.732288806640463 0.672413793103448 17.5 17 5 abnormal long bone morphology 0.00177678872925753 0.0133527551783327 0.731980992934435 0.672131147540984 17.5 17 5 decreased compact bone thickness 0.0011070407351463 0.00902873386451285 0.731448061741909 0.671641791044776 17.5 17 5 thick epidermis 0.000874848042101279 0.00742725086937519 0.731215856008023 0.671428571428571 17.5 17 5 respiratory distress 2.58149062260318e-07 5.5838764554134e-06 0.730226632737074 0.670520231213873 17.5 17 5 increased circulating cholesterol level 2.06038198133643e-07 4.55573349206611e-06 0.730155097996406 0.670454545454545 17.5 17 5 small ovary 0.000171223454909872 0.00186774505225608 0.730019103379532 0.67032967032967 17.5 17 5 increased circulating triglyceride level 2.7927755463409e-06 4.92290876099642e-05 0.728533479426922 0.668965517241379 17.5 17 5 hypoactivity 6.16437874474113e-14 4.14429516960637e-12 0.727955736778685 0.668435013262599 17.5 17 5 abnormal motor capabilities/coordination/movement 9.77971980971416e-06 0.000155444428285393 0.726029927951229 0.666666666666667 17.5 17 5 abnormal limb morphology 0.000778545525154013 0.00666654731091431 0.726029927951229 0.666666666666667 17.5 17 5 abnormal coat appearance 0.00124591206031009 0.00994929775287749 0.726029927951229 0.666666666666667 17.5 17 5 abnormal skin morphology 0.00157785128781325 0.0121139045630724 0.726029927951229 0.666666666666667 17.5 17 5 dilated heart atrium 0.0229659271747011 0.109533099196249 0.726029927951229 0.666666666666667 17.5 17 5 decreased sensitivity to xenobiotic induced morbidity/mortality 0.0229659271747011 0.109533099196249 0.726029927951229 0.666666666666667 17.5 17 5 abnormal incisor morphology 0.00253704117396171 0.0178273726560162 0.726029927951228 0.666666666666667 17.5 17 5 overriding aortic valve 0.00664379835002384 0.0394972814969012 0.726029927951228 0.666666666666667 17.5 17 5 oligodactyly 0.00664379835002384 0.0394972814969012 0.726029927951228 0.666666666666667 17.5 17 5 abnormal reproductive system morphology 0.0108436341699889 0.059874672581237 0.726029927951228 0.666666666666667 17.5 17 5 increased vascular permeability 0.0138924482021756 0.0716216889179517 0.726029927951228 0.666666666666667 17.5 17 5 abnormal circulating hormone level 0.0138924482021756 0.0716216889179517 0.726029927951228 0.666666666666667 17.5 17 5 heart right ventricle hypertrophy 0.0178386524922725 0.0880429525288252 0.726029927951228 0.666666666666667 17.5 17 5 delayed eyelid opening 0.0296583236813048 0.126573879079068 0.726029927951228 0.666666666666667 17.5 17 5 abnormal fat pad morphology 0.0296583236813048 0.126573879079068 0.726029927951228 0.666666666666667 17.5 17 5 abnormal cellular respiration 0.0296583236813048 0.126573879079068 0.726029927951228 0.666666666666667 17.5 17 5 abnormal heart valve morphology 0.0384424961099602 0.158583265461901 0.726029927951228 0.666666666666667 17.5 17 5 abnormal trigeminal nerve morphology 0.0384424961099602 0.158583265461901 0.726029927951228 0.666666666666667 17.5 17 5 abnormal brain commissure morphology 0.0384424961099602 0.158583265461901 0.726029927951228 0.666666666666667 17.5 17 5 abnormal type II pneumocyte morphology 0.0384424961099602 0.158583265461901 0.726029927951228 0.666666666666667 17.5 17 5 abnormal bone trabecula morphology 0.0384424961099602 0.158583265461901 0.726029927951228 0.666666666666667 17.5 17 5 abnormal cardiac muscle contractility 0.0500526286474416 0.186414718074837 0.726029927951228 0.666666666666667 17.5 17 5 increased circulating total protein level 0.0500526286474416 0.186414718074837 0.726029927951228 0.666666666666667 17.5 17 5 abnormal scapula morphology 0.0655345537254862 0.225317487756941 0.726029927951228 0.666666666666667 17.5 17 5 trunk curl 0.0655345537254862 0.225317487756941 0.726029927951228 0.666666666666667 17.5 17 5 decreased cochlear outer hair cell number 0.0655345537254862 0.225317487756941 0.726029927951228 0.666666666666667 17.5 17 5 abnormal clavicle morphology 0.0655345537254862 0.225317487756941 0.726029927951228 0.666666666666667 17.5 17 5 vascular ring 0.0655345537254862 0.225317487756941 0.726029927951228 0.666666666666667 17.5 17 5 right pulmonary isomerism 0.0864221562298246 0.280393779260648 0.726029927951228 0.666666666666667 17.5 17 5 abnormal thyroid cartilage morphology 0.0864221562298246 0.280393779260648 0.726029927951228 0.666666666666667 17.5 17 5 absent allantois 0.0864221562298246 0.280393779260648 0.726029927951228 0.666666666666667 17.5 17 5 increased circulating renin level 0.0864221562298246 0.280393779260648 0.726029927951228 0.666666666666667 17.5 17 5 increased circulating glycerol level 0.0864221562298246 0.280393779260648 0.726029927951228 0.666666666666667 17.5 17 5 darkened coat color 0.0864221562298246 0.280393779260648 0.726029927951228 0.666666666666667 17.5 17 5 atrioventricular block 0.0864221562298246 0.280393779260648 0.726029927951228 0.666666666666667 17.5 17 5 vagina atresia 0.115058967854017 0.318865735728511 0.726029927951228 0.666666666666667 17.5 17 5 abnormal prostate gland morphology 0.115058967854017 0.318865735728511 0.726029927951228 0.666666666666667 17.5 17 5 hyperpigmentation 0.115058967854017 0.318865735728511 0.726029927951228 0.666666666666667 17.5 17 5 placental labyrinth hypoplasia 0.115058967854017 0.318865735728511 0.726029927951228 0.666666666666667 17.5 17 5 abnormal respiratory system morphology 0.115058967854017 0.318865735728511 0.726029927951228 0.666666666666667 17.5 17 5 abnormal cricoid cartilage morphology 0.115058967854017 0.318865735728511 0.726029927951228 0.666666666666667 17.5 17 5 dilated ureter 0.115058967854017 0.318865735728511 0.726029927951228 0.666666666666667 17.5 17 5 abnormal cerebral aqueduct morphology 0.115058967854017 0.318865735728511 0.726029927951228 0.666666666666667 17.5 17 5 abnormal coronary vessel morphology 0.115058967854017 0.318865735728511 0.726029927951228 0.666666666666667 17.5 17 5 herniated liver 0.115058967854017 0.318865735728511 0.726029927951228 0.666666666666667 17.5 17 5 decreased brown adipose tissue mass 0.115058967854017 0.318865735728511 0.726029927951228 0.666666666666667 17.5 17 5 abnormal adipose tissue distribution 0.155246336568245 0.402475520806158 0.726029927951228 0.666666666666667 17.5 17 5 abnormal supraoccipital bone morphology 0.155246336568245 0.402475520806158 0.726029927951228 0.666666666666667 17.5 17 5 abnormal respiratory function 0.155246336568245 0.402475520806158 0.726029927951228 0.666666666666667 17.5 17 5 abnormal AMPA-mediated synaptic currents 0.155246336568245 0.402475520806158 0.726029927951228 0.666666666666667 17.5 17 5 increased circulating parathyroid hormone level 0.155246336568245 0.402475520806158 0.726029927951228 0.666666666666667 17.5 17 5 decreased circulating ketone body level 0.155246336568245 0.402475520806158 0.726029927951228 0.666666666666667 17.5 17 5 absent ovary 0.155246336568245 0.402475520806158 0.726029927951228 0.666666666666667 17.5 17 5 stria vascularis degeneration 0.155246336568245 0.402475520806158 0.726029927951228 0.666666666666667 17.5 17 5 abnormal somatic nervous system physiology 0.155246336568245 0.402475520806158 0.726029927951228 0.666666666666667 17.5 17 5 abnormal thymus corticomedullary boundary morphology 0.155246336568245 0.402475520806158 0.726029927951228 0.666666666666667 17.5 17 5 hydrometra 0.155246336568245 0.402475520806158 0.726029927951228 0.666666666666667 17.5 17 5 abnormal colon goblet cell morphology 0.155246336568245 0.402475520806158 0.726029927951228 0.666666666666667 17.5 17 5 abnormal head movements 0.213751033820759 0.477763709142786 0.726029927951228 0.666666666666667 17.5 17 5 renal tubular acidosis 0.213751033820759 0.477763709142786 0.726029927951228 0.666666666666667 17.5 17 5 abnormal urinary bladder urothelium morphology 0.213751033820759 0.477763709142786 0.726029927951228 0.666666666666667 17.5 17 5 synostosis 0.213751033820759 0.477763709142786 0.726029927951228 0.666666666666667 17.5 17 5 absent parathyroid glands 0.213751033820759 0.477763709142786 0.726029927951228 0.666666666666667 17.5 17 5 wavy vibrissae 0.213751033820759 0.477763709142786 0.726029927951228 0.666666666666667 17.5 17 5 abnormal lens vesicle development 0.213751033820759 0.477763709142786 0.726029927951228 0.666666666666667 17.5 17 5 abnormal ion homeostasis 0.213751033820759 0.477763709142786 0.726029927951228 0.666666666666667 17.5 17 5 decreased circulating bicarbonate level 0.213751033820759 0.477763709142786 0.726029927951228 0.666666666666667 17.5 17 5 genetic imprinting 0.213751033820759 0.477763709142786 0.726029927951228 0.666666666666667 17.5 17 5 enlarged otoliths 0.213751033820759 0.477763709142786 0.726029927951228 0.666666666666667 17.5 17 5 abnormal abdominal wall morphology 0.213751033820759 0.477763709142786 0.726029927951228 0.666666666666667 17.5 17 5 premature neuronal precursor differentiation 0.213751033820759 0.477763709142786 0.726029927951228 0.666666666666667 17.5 17 5 decreased susceptibility to induced choroidal neovascularization 0.213751033820759 0.477763709142786 0.726029927951228 0.666666666666667 17.5 17 5 abnormal ovary physiology 0.213751033820759 0.477763709142786 0.726029927951228 0.666666666666667 17.5 17 5 small scapula 0.213751033820759 0.477763709142786 0.726029927951228 0.666666666666667 17.5 17 5 short frontal bone 0.213751033820759 0.477763709142786 0.726029927951228 0.666666666666667 17.5 17 5 abnormal posterior eye segment morphology 0.213751033820759 0.477763709142786 0.726029927951228 0.666666666666667 17.5 17 5 hemothorax 0.213751033820759 0.477763709142786 0.726029927951228 0.666666666666667 17.5 17 5 positive geotaxis 0.213751033820759 0.477763709142786 0.726029927951228 0.666666666666667 17.5 17 5 abnormal hippocampus granule cell morphology 0.213751033820759 0.477763709142786 0.726029927951228 0.666666666666667 17.5 17 5 retropulsion 0.213751033820759 0.477763709142786 0.726029927951228 0.666666666666667 17.5 17 5 decreased susceptibility to parasitic infection induced morbidity/mortality 0.213751033820759 0.477763709142786 0.726029927951228 0.666666666666667 17.5 17 5 abnormal heart left ventricle pressure 0.213751033820759 0.477763709142786 0.726029927951228 0.666666666666667 17.5 17 5 increased core body temperature 0.213751033820759 0.477763709142786 0.726029927951228 0.666666666666667 17.5 17 5 enhanced leukocyte tethering or rolling 0.213751033820759 0.477763709142786 0.726029927951228 0.666666666666667 17.5 17 5 increased endoplasmic reticulum stress 0.213751033820759 0.477763709142786 0.726029927951228 0.666666666666667 17.5 17 5 neonatal lethality, complete penetrance 6.32333896567574e-16 5.61760917039943e-14 0.723641671609284 0.664473684210526 17.5 17 5 abnormal pulmonary alveolus morphology 0.000135872293031019 0.00155037765557183 0.722435720387114 0.663366336633663 17.5 17 5 hyperactivity 4.68931946285717e-13 2.59215159196827e-11 0.722116019983836 0.663072776280323 17.5 17 5 small seminiferous tubules 0.00110064624615396 0.00899871550638309 0.721124320329936 0.662162162162162 17.5 17 5 corneal opacity 0.00139251800635938 0.0108246516900592 0.720917041134671 0.661971830985915 17.5 17 5 abnormal skeletal muscle fiber morphology 0.00139251800635938 0.0108246516900592 0.720917041134671 0.661971830985915 17.5 17 5 abnormal seminal vesicle morphology 0.00457027923135192 0.0291875984287237 0.719547517880235 0.660714285714286 17.5 17 5 abnormal cholesterol homeostasis 0.0154565298011379 0.0779090534555834 0.717175904439628 0.658536585365854 17.5 17 5 palatal shelves fail to meet at midline 0.0154565298011379 0.0779090534555834 0.717175904439628 0.658536585365854 17.5 17 5 lethality at weaning, incomplete penetrance 0.0154565298011379 0.0779090534555834 0.717175904439628 0.658536585365854 17.5 17 5 decreased startle reflex 6.71316780358883e-05 0.000820839945489725 0.716721851951854 0.658119658119658 17.5 17 5 postnatal lethality, complete penetrance 7.10905860472855e-13 3.80296414607791e-11 0.716625395205746 0.658031088082902 17.5 17 5 abnormal compact bone morphology 0.0198285270629627 0.0959600409905052 0.716476902583449 0.657894736842105 17.5 17 5 hyporesponsive to tactile stimuli 0.0198285270629627 0.0959600409905052 0.716476902583449 0.657894736842105 17.5 17 5 ovary cysts 0.0254991931019789 0.114389978072448 0.71565807183764 0.657142857142857 17.5 17 5 decreased circulating thyroxine level 0.0254991931019789 0.114389978072448 0.71565807183764 0.657142857142857 17.5 17 5 abnormal vertebral body morphology 0.0328849044820419 0.137515405534698 0.714685710326991 0.65625 17.5 17 5 abnormal crypts of Lieberkuhn morphology 0.0328849044820419 0.137515405534698 0.714685710326991 0.65625 17.5 17 5 abnormal heart atrium morphology 0.0328849044820419 0.137515405534698 0.714685710326991 0.65625 17.5 17 5 abnormal depression-related behavior 0.0328849044820419 0.137515405534698 0.714685710326991 0.65625 17.5 17 5 lethargy 0.0004225228057259 0.00401921789385535 0.714319767822983 0.655913978494624 17.5 17 5 cochlear ganglion degeneration 0.00506041480541124 0.0319081922140949 0.713512170572759 0.655172413793103 17.5 17 5 abnormal middle ear morphology 0.042552577221256 0.168015136250594 0.713512170572759 0.655172413793103 17.5 17 5 abnormal parietal bone morphology 0.042552577221256 0.168015136250594 0.713512170572759 0.655172413793103 17.5 17 5 focal hair loss 0.042552577221256 0.168015136250594 0.713512170572759 0.655172413793103 17.5 17 5 enlarged epididymis 0.042552577221256 0.168015136250594 0.713512170572759 0.655172413793103 17.5 17 5 increased retinal apoptosis 0.042552577221256 0.168015136250594 0.713512170572759 0.655172413793103 17.5 17 5 increased exploration in new environment 0.00106983395124857 0.00879739488836636 0.712584929285465 0.654320987654321 17.5 17 5 absent corpus luteum 0.00818699948818981 0.0468164625905107 0.712067813952167 0.653846153846154 17.5 17 5 increased susceptibility to injury 0.00818699948818981 0.0468164625905107 0.712067813952167 0.653846153846154 17.5 17 5 abnormal ureter morphology 0.0552849911033974 0.193555827402816 0.712067813952167 0.653846153846154 17.5 17 5 increased susceptibility to otitis media 0.0552849911033974 0.193555827402816 0.712067813952167 0.653846153846154 17.5 17 5 organ of Corti degeneration 0.0104334898920346 0.0578669032473492 0.711212990646101 0.653061224489796 17.5 17 5 abnormal epidermis stratum corneum morphology 0.0104334898920346 0.0578669032473492 0.711212990646101 0.653061224489796 17.5 17 5 abnormal neuromuscular synapse morphology 0.00215950753869285 0.0155335049689699 0.710904304452245 0.652777777777778 17.5 17 5 abnormal inner ear morphology 0.01331617805238 0.069205751832799 0.710246668647941 0.652173913043478 17.5 17 5 abnormal sleep pattern 0.01331617805238 0.069205751832799 0.710246668647941 0.652173913043478 17.5 17 5 abnormal blood vessel physiology 0.0721825975598934 0.239086832796584 0.710246668647941 0.652173913043478 17.5 17 5 bidirectional circling 0.0721825975598934 0.239086832796584 0.710246668647941 0.652173913043478 17.5 17 5 abnormal postnatal growth 0.0721825975598934 0.239086832796584 0.710246668647941 0.652173913043478 17.5 17 5 abnormal nasal cavity morphology 0.0721825975598934 0.239086832796584 0.710246668647941 0.652173913043478 17.5 17 5 abnormal ulna morphology 0.0721825975598934 0.239086832796584 0.710246668647941 0.652173913043478 17.5 17 5 abnormal hepatocyte physiology 0.0721825975598934 0.239086832796584 0.710246668647941 0.652173913043478 17.5 17 5 hyperkeratosis 0.00273275164975961 0.0187971891624017 0.710246668647941 0.652173913043478 17.5 17 5 reduced long term potentiation 0.000162543702938574 0.00178117824255376 0.709823902773746 0.651785714285714 17.5 17 5 abnormal tail morphology 0.00346073960821627 0.0229868885859492 0.709529247770519 0.651515151515151 17.5 17 5 abnormal kidney morphology 2.92591931923488e-06 5.12551007506815e-05 0.709434958169486 0.651428571428571 17.5 17 5 abnormal male reproductive system morphology 0.0170237870276161 0.0844400204011864 0.70914551102213 0.651162790697674 17.5 17 5 abnormal blood circulation 0.0170237870276161 0.0844400204011864 0.70914551102213 0.651162790697674 17.5 17 5 abnormal pancreatic beta cell morphology 0.0218050427410641 0.104508754948742 0.707879179752448 0.65 17.5 17 5 decreased paired-pulse facilitation 0.0948294182008084 0.292846899782136 0.707879179752448 0.65 17.5 17 5 abnormal lens epithelium morphology 0.0948294182008084 0.292846899782136 0.707879179752448 0.65 17.5 17 5 abnormal circulating cytokine level 0.0948294182008084 0.292846899782136 0.707879179752448 0.65 17.5 17 5 decreased heart rate 0.000406597003136345 0.00387513427318643 0.707879179752448 0.65 17.5 17 5 abnormal blood homeostasis 0.000178384728615131 0.00193769437742418 0.70692387721567 0.649122807017544 17.5 17 5 respiratory failure 1.77045483593235e-05 0.000265301590625404 0.706797347078348 0.649006622516556 17.5 17 5 increased brown adipose tissue amount 0.0279898286630338 0.1206667223558 0.70640749746606 0.648648648648649 17.5 17 5 decreased width of hypertrophic chondrocyte zone 0.0279898286630338 0.1206667223558 0.70640749746606 0.648648648648649 17.5 17 5 abnormal humerus morphology 0.0279898286630338 0.1206667223558 0.70640749746606 0.648648648648649 17.5 17 5 diluted coat color 0.0089807996553687 0.0511206845371387 0.705862429952583 0.648148148148148 17.5 17 5 impaired limb coordination 0.0089807996553687 0.0511206845371387 0.705862429952583 0.648148148148148 17.5 17 5 improved glucose tolerance 1.25783215114586e-06 2.38844082135521e-05 0.705656639156679 0.647959183673469 17.5 17 5 atelectasis 0.00299598225869591 0.0203065555000165 0.705578380684997 0.647887323943662 17.5 17 5 abnormal suckling behavior 0.00102231469580494 0.0085106466471025 0.705404077725341 0.647727272727273 17.5 17 5 small kidney 0.00102231469580494 0.0085106466471025 0.705404077725341 0.647727272727273 17.5 17 5 teratozoospermia 0.00102231469580494 0.0085106466471025 0.705404077725341 0.647727272727273 17.5 17 5 decreased litter size 7.55230213725388e-09 2.27713352320231e-07 0.705360036764005 0.647686832740214 17.5 17 5 abnormal lung morphology 0.00015543338821737 0.00171840245862537 0.704676106540898 0.647058823529412 17.5 17 5 abnormal gluconeogenesis 0.0114293284989672 0.0628297340136593 0.704676106540898 0.647058823529412 17.5 17 5 cochlear inner hair cell degeneration 0.0114293284989672 0.0628297340136593 0.704676106540898 0.647058823529412 17.5 17 5 abnormal cranial suture morphology 0.125579471778687 0.337524512209058 0.704676106540898 0.647058823529412 17.5 17 5 abnormal duodenum morphology 0.125579471778687 0.337524512209058 0.704676106540898 0.647058823529412 17.5 17 5 delayed heart development 0.125579471778687 0.337524512209058 0.704676106540898 0.647058823529412 17.5 17 5 abnormal cell cytoskeleton morphology 0.125579471778687 0.337524512209058 0.704676106540898 0.647058823529412 17.5 17 5 abnormal motor coordination/ balance 0.000559772500513349 0.00509116670942215 0.704029021043616 0.646464646464647 17.5 17 5 increased circulating glucose level 4.76604492191051e-05 0.000611110141404763 0.702858760037891 0.645390070921986 17.5 17 5 absent mature ovarian follicles 0.0464871101453617 0.181248724900607 0.702609607694737 0.645161290322581 17.5 17 5 abnormal nose morphology 0.0464871101453617 0.181248724900607 0.702609607694737 0.645161290322581 17.5 17 5 abnormal capillary morphology 0.0464871101453617 0.181248724900607 0.702609607694737 0.645161290322581 17.5 17 5 abnormal retinal photoreceptor layer morphology 0.0464871101453617 0.181248724900607 0.702609607694737 0.645161290322581 17.5 17 5 abnormal intestine physiology 0.0464871101453617 0.181248724900607 0.702609607694737 0.645161290322581 17.5 17 5 abnormal ovarian follicle morphology 0.0185870804246676 0.0914646143548183 0.701828930352854 0.644444444444444 17.5 17 5 cardiomyopathy 0.0185870804246676 0.0914646143548183 0.701828930352854 0.644444444444444 17.5 17 5 decreased exploration in new environment 0.00176970020799408 0.0133196044398949 0.700100287667256 0.642857142857143 17.5 17 5 abnormal action potential 0.00412889204794846 0.0264706674465768 0.700100287667256 0.642857142857143 17.5 17 5 abnormal cartilage morphology 0.023759741937206 0.111724684440076 0.700100287667256 0.642857142857143 17.5 17 5 abnormal muscle morphology 0.023759741937206 0.111724684440076 0.700100287667256 0.642857142857143 17.5 17 5 abnormal stria vascularis morphology 0.0602052236438291 0.208580074949895 0.700100287667256 0.642857142857143 17.5 17 5 abnormal ovulation 0.0602052236438291 0.208580074949895 0.700100287667256 0.642857142857143 17.5 17 5 failure of blastocyst to hatch from the zona pellucida 0.0602052236438291 0.208580074949895 0.700100287667256 0.642857142857143 17.5 17 5 translucent skin 0.168090628934702 0.417499190689039 0.700100287667256 0.642857142857143 17.5 17 5 abnormal placing response 0.168090628934702 0.417499190689039 0.700100287667256 0.642857142857143 17.5 17 5 abnormal adrenal gland secretion 0.168090628934702 0.417499190689039 0.700100287667256 0.642857142857143 17.5 17 5 decreased coping response 0.168090628934702 0.417499190689039 0.700100287667256 0.642857142857143 17.5 17 5 abnormal voluntary movement 0.168090628934702 0.417499190689039 0.700100287667256 0.642857142857143 17.5 17 5 abnormal imprinting 0.168090628934702 0.417499190689039 0.700100287667256 0.642857142857143 17.5 17 5 abnormal pancreas development 0.168090628934702 0.417499190689039 0.700100287667256 0.642857142857143 17.5 17 5 abnormal iris pigmentation 0.168090628934702 0.417499190689039 0.700100287667256 0.642857142857143 17.5 17 5 premature hair loss 0.168090628934702 0.417499190689039 0.700100287667256 0.642857142857143 17.5 17 5 abnormal glucose tolerance 0.168090628934702 0.417499190689039 0.700100287667256 0.642857142857143 17.5 17 5 abnormal renal tubule epithelial cell primary cilium morphology 0.168090628934702 0.417499190689039 0.700100287667256 0.642857142857143 17.5 17 5 acanthosis 0.0304286678857968 0.1292763644166 0.698105699953104 0.641025641025641 17.5 17 5 abnormal tooth morphology 0.00660519694796884 0.0394962197309435 0.697669383890634 0.640625 17.5 17 5 seizures 0.000363539450729917 0.0034982761458053 0.69737085184789 0.640350877192982 17.5 17 5 increased body length 0.0158141495690303 0.0795504490454255 0.696988730833179 0.64 17.5 17 5 abnormal keratinocyte physiology 0.078295430270696 0.256094520444913 0.696988730833179 0.64 17.5 17 5 decreased acute inflammation 0.078295430270696 0.256094520444913 0.696988730833179 0.64 17.5 17 5 abnormal vertebrae development 0.078295430270696 0.256094520444913 0.696988730833179 0.64 17.5 17 5 abnormal epidermis stratum granulosum morphology 0.039052457257613 0.160037870557351 0.695778680953261 0.638888888888889 17.5 17 5 abnormal limb bone morphology 0.039052457257613 0.160037870557351 0.695778680953261 0.638888888888889 17.5 17 5 head tilt 0.039052457257613 0.160037870557351 0.695778680953261 0.638888888888889 17.5 17 5 narrow eye opening 0.039052457257613 0.160037870557351 0.695778680953261 0.638888888888889 17.5 17 5 abnormal tibia morphology 0.0201404941327792 0.0973750809626592 0.695135037400112 0.638297872340426 17.5 17 5 decreased systemic arterial blood pressure 0.0502431147698884 0.186414718074837 0.693028567589809 0.636363636363636 17.5 17 5 diarrhea 0.0502431147698884 0.186414718074837 0.693028567589809 0.636363636363636 17.5 17 5 hyperglycemia 0.00207415970190949 0.0150641525795616 0.693028567589809 0.636363636363636 17.5 17 5 abnormal facial nerve morphology 0.102338479228053 0.306024780249694 0.693028567589809 0.636363636363636 17.5 17 5 decreased airway responsiveness 0.102338479228053 0.306024780249694 0.693028567589809 0.636363636363636 17.5 17 5 aphakia 0.102338479228053 0.306024780249694 0.693028567589809 0.636363636363636 17.5 17 5 abnormal temporal bone morphology 0.102338479228053 0.306024780249694 0.693028567589809 0.636363636363636 17.5 17 5 rough coat 0.102338479228053 0.306024780249694 0.693028567589809 0.636363636363636 17.5 17 5 premature suture closure 0.228428848963334 0.477763709142786 0.693028567589809 0.636363636363636 17.5 17 5 decreased atrioventricular cushion size 0.228428848963334 0.477763709142786 0.693028567589809 0.636363636363636 17.5 17 5 social withdrawal 0.228428848963334 0.477763709142786 0.693028567589809 0.636363636363636 17.5 17 5 abnormal hemoglobin 0.228428848963334 0.477763709142786 0.693028567589809 0.636363636363636 17.5 17 5 focal hepatic necrosis 0.228428848963334 0.477763709142786 0.693028567589809 0.636363636363636 17.5 17 5 abnormal fear/anxiety-related behavior 0.228428848963334 0.477763709142786 0.693028567589809 0.636363636363636 17.5 17 5 abnormal primary sex determination 0.228428848963334 0.477763709142786 0.693028567589809 0.636363636363636 17.5 17 5 decreased post-tetanic potentiation 0.228428848963334 0.477763709142786 0.693028567589809 0.636363636363636 17.5 17 5 fused joints 0.228428848963334 0.477763709142786 0.693028567589809 0.636363636363636 17.5 17 5 rectal hemorrhage 0.228428848963334 0.477763709142786 0.693028567589809 0.636363636363636 17.5 17 5 pulmonary hypertension 0.228428848963334 0.477763709142786 0.693028567589809 0.636363636363636 17.5 17 5 abnormal radial glial cell morphology 0.228428848963334 0.477763709142786 0.693028567589809 0.636363636363636 17.5 17 5 abnormal ureter development 0.228428848963334 0.477763709142786 0.693028567589809 0.636363636363636 17.5 17 5 pathological neovascularization 0.228428848963334 0.477763709142786 0.693028567589809 0.636363636363636 17.5 17 5 abnormal hair medulla 0.228428848963334 0.477763709142786 0.693028567589809 0.636363636363636 17.5 17 5 abnormal coronal suture morphology 0.228428848963334 0.477763709142786 0.693028567589809 0.636363636363636 17.5 17 5 cyclopia 0.228428848963334 0.477763709142786 0.693028567589809 0.636363636363636 17.5 17 5 increased circulating triiodothyronine level 0.228428848963334 0.477763709142786 0.693028567589809 0.636363636363636 17.5 17 5 abnormal aorta smooth muscle morphology 0.228428848963334 0.477763709142786 0.693028567589809 0.636363636363636 17.5 17 5 palatal shelf hypoplasia 0.228428848963334 0.477763709142786 0.693028567589809 0.636363636363636 17.5 17 5 decreased palatine bone horizontal plate size 0.228428848963334 0.477763709142786 0.693028567589809 0.636363636363636 17.5 17 5 abnormal extraembryonic ectoderm morphology 0.228428848963334 0.477763709142786 0.693028567589809 0.636363636363636 17.5 17 5 abnormal pulmonary alveolar sac morphology 0.228428848963334 0.477763709142786 0.693028567589809 0.636363636363636 17.5 17 5 increased subcutaneous adipose tissue amount 0.228428848963334 0.477763709142786 0.693028567589809 0.636363636363636 17.5 17 5 abnormal brain ependyma motile cilium morphology 0.228428848963334 0.477763709142786 0.693028567589809 0.636363636363636 17.5 17 5 eyelids open at birth 0.0170607420440016 0.0845390355268009 0.691124642953573 0.634615384615385 17.5 17 5 decreased liver weight 0.00608969745242409 0.0368119621212756 0.690239720235323 0.633802816901408 17.5 17 5 abnormal hair cycle 0.0648244696993533 0.223648915918365 0.689728431553667 0.633333333333333 17.5 17 5 enhanced paired-pulse facilitation 0.0648244696993533 0.223648915918365 0.689728431553667 0.633333333333333 17.5 17 5 abnormal synaptic transmission 0.0648244696993533 0.223648915918365 0.689728431553667 0.633333333333333 17.5 17 5 hunched posture 0.00412566577831886 0.0264706674465768 0.68926891894104 0.632911392405063 17.5 17 5 abnormal reproductive system physiology 0.0419806314060131 0.166634554279827 0.687817826480111 0.631578947368421 17.5 17 5 abnormal retinal outer nuclear layer morphology 0.0419806314060131 0.166634554279827 0.687817826480111 0.631578947368421 17.5 17 5 abnormal triglyceride level 0.134614252449983 0.357748881377493 0.687817826480111 0.631578947368421 17.5 17 5 irregular coat pigmentation 0.134614252449983 0.357748881377493 0.687817826480111 0.631578947368421 17.5 17 5 flaky skin 0.134614252449983 0.357748881377493 0.687817826480111 0.631578947368421 17.5 17 5 thin dermal layer 0.134614252449983 0.357748881377493 0.687817826480111 0.631578947368421 17.5 17 5 short vibrissae 0.134614252449983 0.357748881377493 0.687817826480111 0.631578947368421 17.5 17 5 unresponsive to tactile stimuli 0.134614252449983 0.357748881377493 0.687817826480111 0.631578947368421 17.5 17 5 abnormal long term depression 0.134614252449983 0.357748881377493 0.687817826480111 0.631578947368421 17.5 17 5 delayed sexual maturation 0.134614252449983 0.357748881377493 0.687817826480111 0.631578947368421 17.5 17 5 abnormal neurotransmitter level 0.134614252449983 0.357748881377493 0.687817826480111 0.631578947368421 17.5 17 5 abnormal nasal septum morphology 0.134614252449983 0.357748881377493 0.687817826480111 0.631578947368421 17.5 17 5 oliguria 0.134614252449983 0.357748881377493 0.687817826480111 0.631578947368421 17.5 17 5 abnormal cochlear inner hair cell morphology 0.134614252449983 0.357748881377493 0.687817826480111 0.631578947368421 17.5 17 5 increased circulating VLDL cholesterol level 0.134614252449983 0.357748881377493 0.687817826480111 0.631578947368421 17.5 17 5 increased liver cholesterol level 0.134614252449983 0.357748881377493 0.687817826480111 0.631578947368421 17.5 17 5 right-sided stomach 0.134614252449983 0.357748881377493 0.687817826480111 0.631578947368421 17.5 17 5 abnormal forelimb morphology 0.0275786197656287 0.119203851723721 0.68657177969301 0.630434782608696 17.5 17 5 delayed wound healing 0.0275786197656287 0.119203851723721 0.68657177969301 0.630434782608696 17.5 17 5 abnormal trabecular bone morphology 0.000613003737594581 0.00550486208399466 0.68637283104633 0.630252100840336 17.5 17 5 cyanosis 1.62638231323554e-05 0.000245189454798388 0.686325166266396 0.630208333333333 17.5 17 5 abnormal long bone epiphyseal plate proliferative zone 0.0183007316349201 0.0902340335814942 0.685694931953938 0.62962962962963 17.5 17 5 abnormal response to novel object 0.0231991113712415 0.11044553021237 0.683322285130568 0.627450980392157 17.5 17 5 postnatal lethality 8.69537905961415e-05 0.00103739834104509 0.682293185303564 0.626506024096386 17.5 17 5 decreased anxiety-related response 0.000700255307107084 0.00603772990096662 0.681759810393227 0.626016260162602 17.5 17 5 decreased circulating phosphate level 0.0448013764603518 0.17536337363513 0.680653057454277 0.625 17.5 17 5 perinatal lethality 0.0448013764603518 0.17536337363513 0.680653057454277 0.625 17.5 17 5 polydipsia 0.0691574529175616 0.234697004620857 0.680653057454277 0.625 17.5 17 5 bradykinesia 0.0691574529175616 0.234697004620857 0.680653057454277 0.625 17.5 17 5 delayed hair appearance 0.178515856831834 0.440533922489273 0.680653057454277 0.625 17.5 17 5 poor circulation 0.178515856831834 0.440533922489273 0.680653057454277 0.625 17.5 17 5 abnormal meiosis 0.178515856831834 0.440533922489273 0.680653057454277 0.625 17.5 17 5 abnormal olfaction 0.178515856831834 0.440533922489273 0.680653057454277 0.625 17.5 17 5 white spotting 0.178515856831834 0.440533922489273 0.680653057454277 0.625 17.5 17 5 abnormal epicardium morphology 0.178515856831834 0.440533922489273 0.680653057454277 0.625 17.5 17 5 bowed radius 0.178515856831834 0.440533922489273 0.680653057454277 0.625 17.5 17 5 abnormal wound healing 0.178515856831834 0.440533922489273 0.680653057454277 0.625 17.5 17 5 decreased creatinine clearance 0.178515856831834 0.440533922489273 0.680653057454277 0.625 17.5 17 5 impaired behavioral response to addictive substance 0.178515856831834 0.440533922489273 0.680653057454277 0.625 17.5 17 5 dilated respiratory conducting tubes 0.178515856831834 0.440533922489273 0.680653057454277 0.625 17.5 17 5 abnormal pulmonary alveolus wall morphology 0.178515856831834 0.440533922489273 0.680653057454277 0.625 17.5 17 5 abnormal exoccipital bone morphology 0.317716066588199 0.59511951478776 0.680653057454277 0.625 17.5 17 5 pointed snout 0.317716066588199 0.59511951478776 0.680653057454277 0.625 17.5 17 5 abnormal esophageal epithelium morphology 0.317716066588199 0.59511951478776 0.680653057454277 0.625 17.5 17 5 abnormal cecum morphology 0.317716066588199 0.59511951478776 0.680653057454277 0.625 17.5 17 5 abnormal hypoglossal nerve morphology 0.317716066588199 0.59511951478776 0.680653057454277 0.625 17.5 17 5 abnormal pupil morphology 0.317716066588199 0.59511951478776 0.680653057454277 0.625 17.5 17 5 spinning 0.317716066588199 0.59511951478776 0.680653057454277 0.625 17.5 17 5 poor grooming 0.317716066588199 0.59511951478776 0.680653057454277 0.625 17.5 17 5 preneoplasia 0.317716066588199 0.59511951478776 0.680653057454277 0.625 17.5 17 5 coarse hair 0.317716066588199 0.59511951478776 0.680653057454277 0.625 17.5 17 5 abnormal cellular cholesterol metabolism 0.317716066588199 0.59511951478776 0.680653057454277 0.625 17.5 17 5 loss of GABAergic neurons 0.317716066588199 0.59511951478776 0.680653057454277 0.625 17.5 17 5 liver cysts 0.317716066588199 0.59511951478776 0.680653057454277 0.625 17.5 17 5 hair follicle degeneration 0.317716066588199 0.59511951478776 0.680653057454277 0.625 17.5 17 5 increased left ventricle systolic pressure 0.317716066588199 0.59511951478776 0.680653057454277 0.625 17.5 17 5 abnormal skin development 0.317716066588199 0.59511951478776 0.680653057454277 0.625 17.5 17 5 bowed fibula 0.317716066588199 0.59511951478776 0.680653057454277 0.625 17.5 17 5 absent cochlear microphonics 0.317716066588199 0.59511951478776 0.680653057454277 0.625 17.5 17 5 abnormal optic choroid morphology 0.317716066588199 0.59511951478776 0.680653057454277 0.625 17.5 17 5 Sertoli cell hypoplasia 0.317716066588199 0.59511951478776 0.680653057454277 0.625 17.5 17 5 abnormal ilium morphology 0.317716066588199 0.59511951478776 0.680653057454277 0.625 17.5 17 5 absent outer ear 0.317716066588199 0.59511951478776 0.680653057454277 0.625 17.5 17 5 abnormal thymus epithelium morphology 0.317716066588199 0.59511951478776 0.680653057454277 0.625 17.5 17 5 hypergranulosis 0.317716066588199 0.59511951478776 0.680653057454277 0.625 17.5 17 5 impaired behavioral response to alcohol 0.317716066588199 0.59511951478776 0.680653057454277 0.625 17.5 17 5 skin fibrosis 0.317716066588199 0.59511951478776 0.680653057454277 0.625 17.5 17 5 decreased hippocampus pyramidal cell number 0.317716066588199 0.59511951478776 0.680653057454277 0.625 17.5 17 5 decreased susceptibility to weight loss 0.317716066588199 0.59511951478776 0.680653057454277 0.625 17.5 17 5 abnormal circulating serum amyloid protein level 0.317716066588199 0.59511951478776 0.680653057454277 0.625 17.5 17 5 decreased quadriceps weight 0.317716066588199 0.59511951478776 0.680653057454277 0.625 17.5 17 5 ostium secundum atrial septal defect 0.317716066588199 0.59511951478776 0.680653057454277 0.625 17.5 17 5 anomalous pulmonary venous connection 0.317716066588199 0.59511951478776 0.680653057454277 0.625 17.5 17 5 sinoatrial block 0.317716066588199 0.59511951478776 0.680653057454277 0.625 17.5 17 5 delayed suture closure 0.317716066588199 0.59511951478776 0.680653057454277 0.625 17.5 17 5 abnormal heart right ventricle pressure 0.317716066588199 0.59511951478776 0.680653057454277 0.625 17.5 17 5 abnormal stomach position or orientation 0.317716066588199 0.59511951478776 0.680653057454277 0.625 17.5 17 5 abnormal anterior commissure pars posterior morphology 0.317716066588199 0.59511951478776 0.680653057454277 0.625 17.5 17 5 abnormal branching involved in ureteric bud morphogenesis 0.317716066588199 0.59511951478776 0.680653057454277 0.625 17.5 17 5 impaired neuron differentiation 0.317716066588199 0.59511951478776 0.680653057454277 0.625 17.5 17 5 increased circulating ferritin level 0.317716066588199 0.59511951478776 0.680653057454277 0.625 17.5 17 5 increased cornea thickness 0.317716066588199 0.59511951478776 0.680653057454277 0.625 17.5 17 5 decreased white adipose tissue mass 0.317716066588199 0.59511951478776 0.680653057454277 0.625 17.5 17 5 abnormal urine homeostasis 0.00273504349574113 0.0187971891624017 0.680653057454277 0.625 17.5 17 5 abnormal digit morphology 0.00877936142144924 0.0500886732473738 0.680653057454277 0.625 17.5 17 5 abnormal eye development 0.019531070522459 0.0954372019634035 0.680653057454277 0.625 17.5 17 5 enhanced long term potentiation 0.019531070522459 0.0954372019634035 0.680653057454277 0.625 17.5 17 5 abnormal cardiovascular system morphology 0.029433729424995 0.126453198522755 0.680653057454277 0.625 17.5 17 5 abnormal kidney physiology 0.029433729424995 0.126453198522755 0.680653057454277 0.625 17.5 17 5 curly vibrissae 0.109065879080646 0.306024780249694 0.680653057454277 0.625 17.5 17 5 hypopigmentation 0.109065879080646 0.306024780249694 0.680653057454277 0.625 17.5 17 5 increased body temperature 0.109065879080646 0.306024780249694 0.680653057454277 0.625 17.5 17 5 abnormal lung saccule morphology 0.109065879080646 0.306024780249694 0.680653057454277 0.625 17.5 17 5 abnormal epidermal layer morphology 0.0110369164818166 0.0608069318904072 0.678680150041366 0.623188405797101 17.5 17 5 altered response to myocardial infarction 0.0373782938804951 0.154835147423366 0.67762793275448 0.622222222222222 17.5 17 5 decreased osteoclast cell number 0.0373782938804951 0.154835147423366 0.67762793275448 0.622222222222222 17.5 17 5 lethality at weaning, complete penetrance 0.0373782938804951 0.154835147423366 0.67762793275448 0.622222222222222 17.5 17 5 impaired skeletal muscle contractility 0.0572267756629927 0.200213227090991 0.676973851738308 0.621621621621622 17.5 17 5 abnormal circulating glucose level 0.0890913723353124 0.280393779260648 0.675958898437351 0.620689655172414 17.5 17 5 abnormal spinal nerve morphology 0.0890913723353124 0.280393779260648 0.675958898437351 0.620689655172414 17.5 17 5 abnormal hindlimb morphology 0.0312483916771316 0.132645689926391 0.675207832994642 0.62 17.5 17 5 hydronephrosis 0.00668706463632198 0.0394972814969012 0.674170647383284 0.619047619047619 17.5 17 5 arrest of spermatogenesis 0.00668706463632198 0.0394972814969012 0.674170647383284 0.619047619047619 17.5 17 5 abnormal hair follicle morphology 0.017452870414898 0.0863960500637984 0.674170647383284 0.619047619047619 17.5 17 5 small ears 0.142433572973207 0.372363124299372 0.674170647383284 0.619047619047619 17.5 17 5 dry skin 0.142433572973207 0.372363124299372 0.674170647383284 0.619047619047619 17.5 17 5 abnormal embryonic/fetal subventricular zone morphology 0.142433572973207 0.372363124299372 0.674170647383284 0.619047619047619 17.5 17 5 abnormal bile salt homeostasis 0.142433572973207 0.372363124299372 0.674170647383284 0.619047619047619 17.5 17 5 increased circulating calcium level 0.0261706605595735 0.115976836236329 0.673227751372957 0.618181818181818 17.5 17 5 short maxilla 0.0732205434581595 0.242363408984926 0.672645374425403 0.617647058823529 17.5 17 5 cleft secondary palate 0.00480008019604211 0.0305171363440656 0.671963869486775 0.617021276595745 17.5 17 5 abnormal eating behavior 0.0219529530393904 0.105015328241315 0.671577683354886 0.616666666666667 17.5 17 5 abnormal eye physiology 0.0219529530393904 0.105015328241315 0.671577683354886 0.616666666666667 17.5 17 5 deafness 0.00406963648016305 0.0264331329330286 0.671027660682196 0.616161616161616 17.5 17 5 decreased body temperature 0.0330205022948255 0.137515405534698 0.67018147195498 0.615384615384615 17.5 17 5 abnormal xiphoid process morphology 0.115112132938373 0.318865735728511 0.67018147195498 0.615384615384615 17.5 17 5 abnormal Schwann cell morphology 0.115112132938373 0.318865735728511 0.67018147195498 0.615384615384615 17.5 17 5 absent teeth 0.239315589306892 0.496288060359229 0.67018147195498 0.615384615384615 17.5 17 5 abnormal mast cell morphology 0.239315589306892 0.496288060359229 0.67018147195498 0.615384615384615 17.5 17 5 uterus hypoplasia 0.239315589306892 0.496288060359229 0.67018147195498 0.615384615384615 17.5 17 5 abnormal lung interstitium morphology 0.239315589306892 0.496288060359229 0.67018147195498 0.615384615384615 17.5 17 5 increased synaptic depression 0.239315589306892 0.496288060359229 0.67018147195498 0.615384615384615 17.5 17 5 abnormal soleus morphology 0.239315589306892 0.496288060359229 0.67018147195498 0.615384615384615 17.5 17 5 vestibular hair cell degeneration 0.239315589306892 0.496288060359229 0.67018147195498 0.615384615384615 17.5 17 5 increased circulating ammonia level 0.239315589306892 0.496288060359229 0.67018147195498 0.615384615384615 17.5 17 5 increased prostaglandin level 0.239315589306892 0.496288060359229 0.67018147195498 0.615384615384615 17.5 17 5 abnormal hair follicle inner root sheath morphology 0.239315589306892 0.496288060359229 0.67018147195498 0.615384615384615 17.5 17 5 decreased cardiac stroke volume 0.239315589306892 0.496288060359229 0.67018147195498 0.615384615384615 17.5 17 5 small lens 0.0604637730383586 0.209184472090288 0.67018147195498 0.615384615384615 17.5 17 5 abnormal iris morphology 0.0604637730383586 0.209184472090288 0.67018147195498 0.615384615384615 17.5 17 5 dehydration 0.0155107642180068 0.0781032914823723 0.668984719326489 0.614285714285714 17.5 17 5 abnormal gametogenesis 0.0501206910916856 0.186414718074837 0.668277547318744 0.613636363636364 17.5 17 5 renal interstitial fibrosis 0.0501206910916856 0.186414718074837 0.668277547318744 0.613636363636364 17.5 17 5 increased circulating insulin level 0.000445164168862326 0.00421846045731442 0.667039996305191 0.6125 17.5 17 5 abnormal social investigation 0.0110094391434367 0.0607227935017709 0.667039996305191 0.6125 17.5 17 5 increased fluid intake 0.0416777839327097 0.166634554279827 0.66676217873072 0.612244897959184 17.5 17 5 increased total body fat amount 0.001295498594767 0.0102956957012234 0.66643045625374 0.611940298507463 17.5 17 5 circling 0.00928884301408109 0.0527710523618773 0.666239228002304 0.611764705882353 17.5 17 5 abnormal mandible morphology 0.0347486208536057 0.144423048242848 0.665527433955293 0.611111111111111 17.5 17 5 abnormal uterus morphology 0.0770305852789186 0.252455310779065 0.665527433955293 0.611111111111111 17.5 17 5 impaired wound healing 0.0770305852789186 0.252455310779065 0.665527433955293 0.611111111111111 17.5 17 5 abnormal retinal rod cell morphology 0.187112396212613 0.459923009465292 0.665527433955293 0.611111111111111 17.5 17 5 abnormal phrenic nerve morphology 0.187112396212613 0.459923009465292 0.665527433955293 0.611111111111111 17.5 17 5 eye inflammation 0.187112396212613 0.459923009465292 0.665527433955293 0.611111111111111 17.5 17 5 acidosis 0.187112396212613 0.459923009465292 0.665527433955293 0.611111111111111 17.5 17 5 absent ureter 0.187112396212613 0.459923009465292 0.665527433955293 0.611111111111111 17.5 17 5 abnormal anterior eye segment morphology 0.187112396212613 0.459923009465292 0.665527433955293 0.611111111111111 17.5 17 5 decreased insulin secretion 0.00784382779398538 0.0453229306330746 0.665527433955293 0.611111111111111 17.5 17 5 polyuria 0.0137327138951172 0.0710928737026097 0.664741687280021 0.61038961038961 17.5 17 5 abnormal colon morphology 0.0290366087835506 0.124962914098758 0.664501967955362 0.610169491525424 17.5 17 5 abnormal cochlear ganglion morphology 0.149247628489634 0.389562933754422 0.662896890738078 0.608695652173913 17.5 17 5 increased body weight 7.22222753232414e-05 0.000874223405676706 0.661205827241297 0.607142857142857 17.5 17 5 abnormal hormone level 0.120563064603422 0.325095526505163 0.661205827241297 0.607142857142857 17.5 17 5 abnormal male meiosis 0.0304262930186182 0.1292763644166 0.660568213135954 0.60655737704918 17.5 17 5 impaired swimming 0.0254618018648843 0.114389978072448 0.66002720722839 0.606060606060606 17.5 17 5 belly spot 0.0982564346832125 0.302866023884128 0.66002720722839 0.606060606060606 17.5 17 5 dextrocardia 0.0982564346832125 0.302866023884128 0.66002720722839 0.606060606060606 17.5 17 5 absent vibrissae 0.0982564346832125 0.302866023884128 0.66002720722839 0.606060606060606 17.5 17 5 abnormal frontal bone morphology 0.0806041968570286 0.263299986450241 0.659158750376773 0.605263157894737 17.5 17 5 increased grooming behavior 0.0806041968570286 0.263299986450241 0.659158750376773 0.605263157894737 17.5 17 5 abnormal intestinal mucosa morphology 0.0664603221297814 0.226621043588528 0.658492260234835 0.604651162790698 17.5 17 5 decreased oxygen consumption 0.0664603221297814 0.226621043588528 0.658492260234835 0.604651162790698 17.5 17 5 abnormal locomotor activation 0.0106864139246533 0.0591378301169632 0.65821394567007 0.604395604395604 17.5 17 5 abnormal hair shaft morphology 0.0550216128613523 0.192905231843007 0.657964622205801 0.604166666666667 17.5 17 5 abnormal phalanx morphology 0.0550216128613523 0.192905231843007 0.657964622205801 0.604166666666667 17.5 17 5 abnormal female reproductive system morphology 0.0839573679053693 0.273893708412598 0.653426935156106 0.6 17.5 17 5 impaired ovarian folliculogenesis 0.0839573679053693 0.273893708412598 0.653426935156106 0.6 17.5 17 5 abnormal intestinal goblet cell morphology 0.102318764746552 0.306024780249694 0.653426935156106 0.6 17.5 17 5 impaired adaptive thermogenesis 0.102318764746552 0.306024780249694 0.653426935156106 0.6 17.5 17 5 waved hair 0.194291503823745 0.466731159595912 0.653426935156106 0.6 17.5 17 5 increased urine glucose level 0.194291503823745 0.466731159595912 0.653426935156106 0.6 17.5 17 5 abnormal heart right ventricle morphology 0.194291503823745 0.466731159595912 0.653426935156106 0.6 17.5 17 5 decreased circulating VLDL cholesterol level 0.194291503823745 0.466731159595912 0.653426935156106 0.6 17.5 17 5 abnormal heart electrocardiography waveform feature 0.194291503823745 0.466731159595912 0.653426935156106 0.6 17.5 17 5 abnormal lateral semicircular canal morphology 0.325721512056935 0.60646127338445 0.653426935156106 0.6 17.5 17 5 jaundice 0.325721512056935 0.60646127338445 0.653426935156106 0.6 17.5 17 5 abnormal pituitary secretion 0.325721512056935 0.60646127338445 0.653426935156106 0.6 17.5 17 5 ketoaciduria 0.325721512056935 0.60646127338445 0.653426935156106 0.6 17.5 17 5 abnormal neuron specification 0.325721512056935 0.60646127338445 0.653426935156106 0.6 17.5 17 5 delayed dark adaptation 0.325721512056935 0.60646127338445 0.653426935156106 0.6 17.5 17 5 impaired basement membrane formation 0.325721512056935 0.60646127338445 0.653426935156106 0.6 17.5 17 5 abnormal scala media morphology 0.325721512056935 0.60646127338445 0.653426935156106 0.6 17.5 17 5 cochlear ganglion hypoplasia 0.325721512056935 0.60646127338445 0.653426935156106 0.6 17.5 17 5 abnormal pillar cell morphology 0.325721512056935 0.60646127338445 0.653426935156106 0.6 17.5 17 5 abnormal hindlimb zeugopod morphology 0.325721512056935 0.60646127338445 0.653426935156106 0.6 17.5 17 5 decreased cochlear inner hair cell number 0.325721512056935 0.60646127338445 0.653426935156106 0.6 17.5 17 5 abnormal spinal cord dorsal column morphology 0.325721512056935 0.60646127338445 0.653426935156106 0.6 17.5 17 5 abnormal sperm principal piece morphology 0.325721512056935 0.60646127338445 0.653426935156106 0.6 17.5 17 5 sinus bradycardia 0.325721512056935 0.60646127338445 0.653426935156106 0.6 17.5 17 5 fusion of atlas and odontoid process 0.325721512056935 0.60646127338445 0.653426935156106 0.6 17.5 17 5 impaired righting response 0.011614644089553 0.0634279411037608 0.653426935156106 0.6 17.5 17 5 abnormal axon extension 0.0573218723160768 0.200404999840114 0.653426935156106 0.6 17.5 17 5 abnormal cartilage development 0.0692342869084708 0.234697004620857 0.653426935156106 0.6 17.5 17 5 abnormal autopod morphology 0.0692342869084708 0.234697004620857 0.653426935156106 0.6 17.5 17 5 increased circulating corticosterone level 0.0692342869084708 0.234697004620857 0.653426935156106 0.6 17.5 17 5 interdigital webbing 0.24763812055573 0.510356110093106 0.653426935156106 0.6 17.5 17 5 abnormal enteric neuron morphology 0.24763812055573 0.510356110093106 0.653426935156106 0.6 17.5 17 5 abnormal epidermis stratum spinosum morphology 0.24763812055573 0.510356110093106 0.653426935156106 0.6 17.5 17 5 abnormal pup retrieval 0.24763812055573 0.510356110093106 0.653426935156106 0.6 17.5 17 5 no suckling reflex 0.24763812055573 0.510356110093106 0.653426935156106 0.6 17.5 17 5 abnormal apical ectodermal ridge morphology 0.24763812055573 0.510356110093106 0.653426935156106 0.6 17.5 17 5 abnormal bronchus morphology 0.24763812055573 0.510356110093106 0.653426935156106 0.6 17.5 17 5 joint inflammation 0.24763812055573 0.510356110093106 0.653426935156106 0.6 17.5 17 5 abnormal glial cell morphology 0.24763812055573 0.510356110093106 0.653426935156106 0.6 17.5 17 5 abnormal ear development 0.24763812055573 0.510356110093106 0.653426935156106 0.6 17.5 17 5 abnormal olfactory nerve morphology 0.24763812055573 0.510356110093106 0.653426935156106 0.6 17.5 17 5 abnormal neurotransmitter secretion 0.24763812055573 0.510356110093106 0.653426935156106 0.6 17.5 17 5 abnormal energy homeostasis 0.24763812055573 0.510356110093106 0.653426935156106 0.6 17.5 17 5 lactation failure 0.24763812055573 0.510356110093106 0.653426935156106 0.6 17.5 17 5 abnormal branching involved in lung morphogenesis 0.24763812055573 0.510356110093106 0.653426935156106 0.6 17.5 17 5 abnormal neuron differentiation 0.00726258502660934 0.0427084639567157 0.651482212134808 0.598214285714286 17.5 17 5 abnormal heart left ventricle morphology 0.0287941782495605 0.124026871681007 0.650401810456309 0.597222222222222 17.5 17 5 increased anxiety-related response 0.00327841734585987 0.0220109666608001 0.650292993021064 0.597122302158273 17.5 17 5 abnormal craniofacial bone morphology 0.0494614909532228 0.186414718074837 0.649605725008994 0.596491228070175 17.5 17 5 decreased cardiac muscle contractility 0.0105733998166932 0.0585775769354665 0.649238300956387 0.596153846153846 17.5 17 5 abnormal hair growth 0.0595263232726666 0.206659775493033 0.649238300956387 0.596153846153846 17.5 17 5 abnormal CNS synaptic transmission 0.0125358245812241 0.0664171749644194 0.649026753774583 0.595959595959596 17.5 17 5 abnormal nervous system electrophysiology 0.0210214654387988 0.100850328406966 0.648241007099311 0.595238095238095 17.5 17 5 increased circulating follicle stimulating hormone level 0.129960331462657 0.34854590244028 0.646620404581563 0.59375 17.5 17 5 abnormal auditory brainstem response waveform shape 0.129960331462657 0.34854590244028 0.646620404581563 0.59375 17.5 17 5 increased liver weight 0.0225129440462334 0.107590678799242 0.64352652704768 0.590909090909091 17.5 17 5 hypertension 0.0900620114070304 0.280393779260648 0.64352652704768 0.590909090909091 17.5 17 5 intestinal ulcer 0.200348708382873 0.477763709142786 0.64352652704768 0.590909090909091 17.5 17 5 increased body size 0.200348708382873 0.477763709142786 0.64352652704768 0.590909090909091 17.5 17 5 abnormal tail movements 0.200348708382873 0.477763709142786 0.64352652704768 0.590909090909091 17.5 17 5 abnormal channel response 0.200348708382873 0.477763709142786 0.64352652704768 0.590909090909091 17.5 17 5 abnormal retinal layer morphology 0.200348708382873 0.477763709142786 0.64352652704768 0.590909090909091 17.5 17 5 abnormal retinal outer plexiform layer morphology 0.200348708382873 0.477763709142786 0.64352652704768 0.590909090909091 17.5 17 5 cleft upper lip 0.200348708382873 0.477763709142786 0.64352652704768 0.590909090909091 17.5 17 5 abnormal excitatory postsynaptic currents 0.031934027831458 0.135440569873405 0.642257243956856 0.58974358974359 17.5 17 5 increased width of hypertrophic chondrocyte zone 0.134021993576145 0.357748881377493 0.640614642309908 0.588235294117647 17.5 17 5 decreased osteoblast cell number 0.134021993576145 0.357748881377493 0.640614642309908 0.588235294117647 17.5 17 5 hydroureter 0.254139264050616 0.522671698491862 0.640614642309908 0.588235294117647 17.5 17 5 enlarged sebaceous gland 0.254139264050616 0.522671698491862 0.640614642309908 0.588235294117647 17.5 17 5 abnormal testis development 0.254139264050616 0.522671698491862 0.640614642309908 0.588235294117647 17.5 17 5 common atrium 0.254139264050616 0.522671698491862 0.640614642309908 0.588235294117647 17.5 17 5 decreased body fat mass 0.254139264050616 0.522671698491862 0.640614642309908 0.588235294117647 17.5 17 5 distended abdomen 0.0767462954086709 0.252455310779065 0.640614642309907 0.588235294117647 17.5 17 5 abnormal enzyme/coenzyme level 0.0655998501051884 0.225386225326873 0.638405626301942 0.586206896551724 17.5 17 5 absent long term depression 0.165147961983245 0.412455376941086 0.638405626301942 0.586206896551724 17.5 17 5 abnormal foregut morphology 0.205502077662217 0.477763709142786 0.635276186957325 0.583333333333333 17.5 17 5 abnormal body weight 0.205502077662217 0.477763709142786 0.635276186957325 0.583333333333333 17.5 17 5 apnea 0.205502077662217 0.477763709142786 0.635276186957325 0.583333333333333 17.5 17 5 abnormal sensory capabilities/reflexes/nociception 0.205502077662217 0.477763709142786 0.635276186957325 0.583333333333333 17.5 17 5 abnormal osteoblast morphology 0.205502077662217 0.477763709142786 0.635276186957325 0.583333333333333 17.5 17 5 abnormal mineral level 0.330884366316459 0.612634805517076 0.635276186957325 0.583333333333333 17.5 17 5 mesocardia 0.330884366316459 0.612634805517076 0.635276186957325 0.583333333333333 17.5 17 5 absent optic nerve 0.330884366316459 0.612634805517076 0.635276186957325 0.583333333333333 17.5 17 5 abnormal pilomotor reflex 0.330884366316459 0.612634805517076 0.635276186957325 0.583333333333333 17.5 17 5 abnormal tracheal ciliated epithelium morphology 0.330884366316459 0.612634805517076 0.635276186957325 0.583333333333333 17.5 17 5 abnormal corticospinal tract morphology 0.330884366316459 0.612634805517076 0.635276186957325 0.583333333333333 17.5 17 5 small thyroid gland 0.330884366316459 0.612634805517076 0.635276186957325 0.583333333333333 17.5 17 5 abnormal gastrocnemius morphology 0.330884366316459 0.612634805517076 0.635276186957325 0.583333333333333 17.5 17 5 abnormal aorta elastic fiber morphology 0.330884366316459 0.612634805517076 0.635276186957325 0.583333333333333 17.5 17 5 dilated bile duct 0.330884366316459 0.612634805517076 0.635276186957325 0.583333333333333 17.5 17 5 increased fear-related response 0.330884366316459 0.612634805517076 0.635276186957325 0.583333333333333 17.5 17 5 decreased left ventricle systolic pressure 0.330884366316459 0.612634805517076 0.635276186957325 0.583333333333333 17.5 17 5 decreased cochlear nerve compound action potential 0.330884366316459 0.612634805517076 0.635276186957325 0.583333333333333 17.5 17 5 abnormal palatine bone morphology 0.330884366316459 0.612634805517076 0.635276186957325 0.583333333333333 17.5 17 5 hemoperitoneum 0.330884366316459 0.612634805517076 0.635276186957325 0.583333333333333 17.5 17 5 abnormal femur morphology 0.0577583872761542 0.201789309479541 0.633921653509655 0.582089552238806 17.5 17 5 short femur 0.0367283481049724 0.152523816212218 0.631151016912147 0.579545454545455 17.5 17 5 abnormal response to novelty 0.259297343886229 0.531960530240821 0.630499674273435 0.578947368421053 17.5 17 5 maternal imprinting 0.259297343886229 0.531960530240821 0.630499674273435 0.578947368421053 17.5 17 5 increased left ventricle weight 0.259297343886229 0.531960530240821 0.630499674273435 0.578947368421053 17.5 17 5 eyelids fail to open 0.259297343886229 0.531960530240821 0.630499674273435 0.578947368421053 17.5 17 5 decreased liver regeneration 0.259297343886229 0.531960530240821 0.630499674273435 0.578947368421053 17.5 17 5 decreased liver glycogen level 0.259297343886229 0.531960530240821 0.630499674273435 0.578947368421053 17.5 17 5 abnormal stomach morphology 0.209916215055388 0.477763709142786 0.628295129957794 0.576923076923077 17.5 17 5 abnormal nerve conduction 0.209916215055388 0.477763709142786 0.628295129957794 0.576923076923077 17.5 17 5 increased susceptibility to weight loss 0.144189575413597 0.376755849623239 0.626200812857935 0.575 17.5 17 5 abnormal innervation 0.121153627856712 0.326510995984366 0.625621533660101 0.574468085106383 17.5 17 5 abnormal cochlea morphology 0.10240884458867 0.306024780249694 0.625192437958002 0.574074074074074 17.5 17 5 obese 0.0646659333019163 0.223567073090364 0.622311366815339 0.571428571428571 17.5 17 5 impaired fertilization 0.075629328369497 0.250170152020111 0.622311366815339 0.571428571428571 17.5 17 5 absent kidney 0.123566085087289 0.332832308234577 0.622311366815339 0.571428571428571 17.5 17 5 abnormal optic nerve morphology 0.147019857122929 0.383949495635995 0.622311366815339 0.571428571428571 17.5 17 5 myoclonus 0.213717825226393 0.477763709142786 0.622311366815339 0.571428571428571 17.5 17 5 enhanced coordination 0.213717825226393 0.477763709142786 0.622311366815339 0.571428571428571 17.5 17 5 abnormal associative learning 0.263435411624463 0.539782196388676 0.622311366815339 0.571428571428571 17.5 17 5 increased vasoconstriction 0.263435411624463 0.539782196388676 0.622311366815339 0.571428571428571 17.5 17 5 increased bone ossification 0.263435411624463 0.539782196388676 0.622311366815339 0.571428571428571 17.5 17 5 abnormal interparietal bone morphology 0.334282203136479 0.616631056953646 0.622311366815339 0.571428571428571 17.5 17 5 absent atrioventricular cushions 0.334282203136479 0.616631056953646 0.622311366815339 0.571428571428571 17.5 17 5 megacephaly 0.334282203136479 0.616631056953646 0.622311366815339 0.571428571428571 17.5 17 5 irregularly shaped pupil 0.334282203136479 0.616631056953646 0.622311366815339 0.571428571428571 17.5 17 5 increased aggression towards males 0.334282203136479 0.616631056953646 0.622311366815339 0.571428571428571 17.5 17 5 intestinal obstruction 0.334282203136479 0.616631056953646 0.622311366815339 0.571428571428571 17.5 17 5 abnormal decidualization 0.334282203136479 0.616631056953646 0.622311366815339 0.571428571428571 17.5 17 5 decreased cornea thickness 0.334282203136479 0.616631056953646 0.622311366815339 0.571428571428571 17.5 17 5 sternebra fusion 0.334282203136479 0.616631056953646 0.622311366815339 0.571428571428571 17.5 17 5 abnormal eye electrophysiology 0.026884458095182 0.116405725869043 0.62102559952853 0.570247933884298 17.5 17 5 abnormal photoreceptor outer segment morphology 0.14961654178783 0.390321077815654 0.618775506776615 0.568181818181818 17.5 17 5 abnormal breathing pattern 0.179257647813627 0.441926064357181 0.618106560282803 0.567567567567568 17.5 17 5 increased insulin secretion 0.179257647813627 0.441926064357181 0.618106560282803 0.567567567567568 17.5 17 5 abnormal pancreatic islet morphology 0.12791215932832 0.343608527353343 0.616440504864251 0.566037735849057 17.5 17 5 fragile skeleton 0.266780112244086 0.5455121489578 0.615547112828216 0.565217391304348 17.5 17 5 abnormal carpal bone morphology 0.266780112244086 0.5455121489578 0.615547112828216 0.565217391304348 17.5 17 5 hypotension 0.266780112244086 0.5455121489578 0.615547112828216 0.565217391304348 17.5 17 5 decreased epididymis weight 0.266780112244086 0.5455121489578 0.615547112828216 0.565217391304348 17.5 17 5 increased susceptibility to fungal infection 0.266780112244086 0.5455121489578 0.615547112828216 0.565217391304348 17.5 17 5 abnormal contextual conditioning behavior 0.129870086525007 0.34854590244028 0.613825302722402 0.563636363636364 17.5 17 5 kidney cortex cysts 0.219859936574767 0.477763709142786 0.612587751708849 0.5625 17.5 17 5 abnormal tympanic ring morphology 0.336509602486452 0.618138479158839 0.612587751708849 0.5625 17.5 17 5 abnormal extraembryonic endoderm formation 0.336509602486452 0.618138479158839 0.612587751708849 0.5625 17.5 17 5 decreased cochlear coiling 0.336509602486452 0.618138479158839 0.612587751708849 0.5625 17.5 17 5 abnormal pulmonary elastic fiber morphology 0.336509602486452 0.618138479158839 0.612587751708849 0.5625 17.5 17 5 increased pancreatic beta cell number 0.336509602486452 0.618138479158839 0.612587751708849 0.5625 17.5 17 5 small pancreas 0.336509602486452 0.618138479158839 0.612587751708849 0.5625 17.5 17 5 bowed tibia 0.336509602486452 0.618138479158839 0.612587751708849 0.5625 17.5 17 5 small epididymis 0.336509602486452 0.618138479158839 0.612587751708849 0.5625 17.5 17 5 abnormal fertilization 0.336509602486452 0.618138479158839 0.612587751708849 0.5625 17.5 17 5 abnormal nest building behavior 0.269495473583401 0.547366069120609 0.609865139479032 0.56 17.5 17 5 abnormal energy expenditure 0.269495473583401 0.547366069120609 0.609865139479032 0.56 17.5 17 5 abnormal retinal photoreceptor morphology 0.222342784783291 0.477763709142786 0.608583910194412 0.558823529411765 17.5 17 5 thin skin 0.222342784783291 0.477763709142786 0.608583910194412 0.558823529411765 17.5 17 5 abnormal bone remodeling 0.222342784783291 0.477763709142786 0.608583910194412 0.558823529411765 17.5 17 5 abnormal maternal nurturing 0.135005962885721 0.358598326404944 0.607008628287093 0.557377049180328 17.5 17 5 abnormal systemic arterial blood pressure 0.224506402033559 0.477763709142786 0.605024939959357 0.555555555555556 17.5 17 5 short radius 0.224506402033559 0.477763709142786 0.605024939959357 0.555555555555556 17.5 17 5 cryptorchism 0.271703317072327 0.547366069120609 0.605024939959357 0.555555555555556 17.5 17 5 lowered ear position 0.33792284884812 0.618138479158839 0.605024939959357 0.555555555555556 17.5 17 5 delayed kidney development 0.33792284884812 0.618138479158839 0.605024939959357 0.555555555555556 17.5 17 5 absent spleen 0.33792284884812 0.618138479158839 0.605024939959357 0.555555555555556 17.5 17 5 thick dermal layer 0.33792284884812 0.618138479158839 0.605024939959357 0.555555555555556 17.5 17 5 decreased heart rate variability 0.33792284884812 0.618138479158839 0.605024939959357 0.555555555555556 17.5 17 5 abnormal sperm axoneme morphology 0.33792284884812 0.618138479158839 0.605024939959357 0.555555555555556 17.5 17 5 deformed nails 0.4476723575475 0.653352834682998 0.605024939959357 0.555555555555556 17.5 17 5 abnormal geniculate ganglion morphology 0.4476723575475 0.653352834682998 0.605024939959357 0.555555555555556 17.5 17 5 abnormal vagina epithelium morphology 0.4476723575475 0.653352834682998 0.605024939959357 0.555555555555556 17.5 17 5 abnormal vomeronasal organ morphology 0.4476723575475 0.653352834682998 0.605024939959357 0.555555555555556 17.5 17 5 long gestation period 0.4476723575475 0.653352834682998 0.605024939959357 0.555555555555556 17.5 17 5 polycythemia 0.4476723575475 0.653352834682998 0.605024939959357 0.555555555555556 17.5 17 5 priapism 0.4476723575475 0.653352834682998 0.605024939959357 0.555555555555556 17.5 17 5 brittle hair 0.4476723575475 0.653352834682998 0.605024939959357 0.555555555555556 17.5 17 5 abnormal proprioceptive neuron morphology 0.4476723575475 0.653352834682998 0.605024939959357 0.555555555555556 17.5 17 5 abnormal intervertebral disk development 0.4476723575475 0.653352834682998 0.605024939959357 0.555555555555556 17.5 17 5 increased tidal volume 0.4476723575475 0.653352834682998 0.605024939959357 0.555555555555556 17.5 17 5 enhanced conditioned place preference behavior 0.4476723575475 0.653352834682998 0.605024939959357 0.555555555555556 17.5 17 5 multiflagellated sperm 0.4476723575475 0.653352834682998 0.605024939959357 0.555555555555556 17.5 17 5 abnormal cerebellar layer morphology 0.4476723575475 0.653352834682998 0.605024939959357 0.555555555555556 17.5 17 5 fusion of atlas and occipital bones 0.4476723575475 0.653352834682998 0.605024939959357 0.555555555555556 17.5 17 5 decreased airway resistance 0.4476723575475 0.653352834682998 0.605024939959357 0.555555555555556 17.5 17 5 decreased pancreatic beta cell proliferation 0.4476723575475 0.653352834682998 0.605024939959357 0.555555555555556 17.5 17 5 abnormal coronary sinus connection 0.4476723575475 0.653352834682998 0.605024939959357 0.555555555555556 17.5 17 5 increased bone mineralization 0.4476723575475 0.653352834682998 0.605024939959357 0.555555555555556 17.5 17 5 pulmonary hypoplasia 0.190195197710806 0.464945567862739 0.602450365746764 0.553191489361702 17.5 17 5 increased systemic arterial blood pressure 0.190195197710806 0.464945567862739 0.602450365746764 0.553191489361702 17.5 17 5 impaired branching involved in ureteric bud morphogenesis 0.226393393351381 0.477763709142786 0.601840598170097 0.552631578947368 17.5 17 5 aphagia 0.27349611844873 0.547366069120609 0.600852354166534 0.551724137931034 17.5 17 5 stomach inflammation 0.27349611844873 0.547366069120609 0.600852354166534 0.551724137931034 17.5 17 5 abnormal skin pigmentation 0.228039173475555 0.477763709142786 0.598974690559764 0.55 17.5 17 5 abnormal dopamine level 0.338748926184821 0.618138479158839 0.598974690559764 0.55 17.5 17 5 abnormal trachea morphology 0.338748926184821 0.618138479158839 0.598974690559764 0.55 17.5 17 5 absent placental labyrinth 0.338748926184821 0.618138479158839 0.598974690559764 0.55 17.5 17 5 abnormal postnatal subventricular zone morphology 0.338748926184821 0.618138479158839 0.598974690559764 0.55 17.5 17 5 abnormal incus morphology 0.338748926184821 0.618138479158839 0.598974690559764 0.55 17.5 17 5 abnormal basisphenoid bone morphology 0.339139455514371 0.618138479158839 0.594024486505551 0.545454545454545 17.5 17 5 increased coping response 0.339139455514371 0.618138479158839 0.594024486505551 0.545454545454545 17.5 17 5 decreased cardiac output 0.339139455514371 0.618138479158839 0.594024486505551 0.545454545454545 17.5 17 5 abnormal basement membrane morphology 0.339139455514371 0.618138479158839 0.594024486505551 0.545454545454545 17.5 17 5 failure of palatal shelf elevation 0.339139455514371 0.618138479158839 0.594024486505551 0.545454545454545 17.5 17 5 abnormal ear position 0.442472707769256 0.653352834682998 0.594024486505551 0.545454545454545 17.5 17 5 absent semicircular canals 0.442472707769256 0.653352834682998 0.594024486505551 0.545454545454545 17.5 17 5 abnormal awl hair morphology 0.442472707769256 0.653352834682998 0.594024486505551 0.545454545454545 17.5 17 5 abnormal enteric ganglia morphology 0.442472707769256 0.653352834682998 0.594024486505551 0.545454545454545 17.5 17 5 abnormal bronchiole morphology 0.442472707769256 0.653352834682998 0.594024486505551 0.545454545454545 17.5 17 5 abnormal vestibular ganglion morphology 0.442472707769256 0.653352834682998 0.594024486505551 0.545454545454545 17.5 17 5 retinal detachment 0.442472707769256 0.653352834682998 0.594024486505551 0.545454545454545 17.5 17 5 impaired luteinization 0.442472707769256 0.653352834682998 0.594024486505551 0.545454545454545 17.5 17 5 abnormal nerve fiber response 0.442472707769256 0.653352834682998 0.594024486505551 0.545454545454545 17.5 17 5 enlarged placenta 0.442472707769256 0.653352834682998 0.594024486505551 0.545454545454545 17.5 17 5 abnormal Bruch membrane morphology 0.442472707769256 0.653352834682998 0.594024486505551 0.545454545454545 17.5 17 5 abnormal palatal shelf elevation 0.442472707769256 0.653352834682998 0.594024486505551 0.545454545454545 17.5 17 5 abnormal phrenic nerve innervation pattern to diaphragm 0.442472707769256 0.653352834682998 0.594024486505551 0.545454545454545 17.5 17 5 syndactyly 0.197707230231535 0.474707273359984 0.590668415960321 0.542372881355932 17.5 17 5 increased stereotypic behavior 0.339199607659021 0.618138479158839 0.589899316460373 0.541666666666667 17.5 17 5 increased white adipose tissue amount 0.277740230527597 0.547366069120609 0.58867291455505 0.540540540540541 17.5 17 5 abnormal pancreatic beta cell physiology 0.277740230527597 0.547366069120609 0.58867291455505 0.540540540540541 17.5 17 5 abnormal kidney cortex morphology 0.339004608532749 0.618138479158839 0.586408787960608 0.538461538461538 17.5 17 5 no spontaneous movement 0.339004608532749 0.618138479158839 0.586408787960608 0.538461538461538 17.5 17 5 dystrophic cardiac calcinosis 0.437714606160953 0.653352834682998 0.586408787960608 0.538461538461538 17.5 17 5 abnormal otolith morphology 0.437714606160953 0.653352834682998 0.586408787960608 0.538461538461538 17.5 17 5 absent lateral semicircular canal 0.437714606160953 0.653352834682998 0.586408787960608 0.538461538461538 17.5 17 5 abnormal dopaminergic neuron morphology 0.437714606160953 0.653352834682998 0.586408787960608 0.538461538461538 17.5 17 5 abnormal GABAergic neuron morphology 0.437714606160953 0.653352834682998 0.586408787960608 0.538461538461538 17.5 17 5 abnormal afterhyperpolarization 0.437714606160953 0.653352834682998 0.586408787960608 0.538461538461538 17.5 17 5 abnormal vestibulocochlear ganglion morphology 0.437714606160953 0.653352834682998 0.586408787960608 0.538461538461538 17.5 17 5 increased circulating thyroid-stimulating hormone level 0.437714606160953 0.653352834682998 0.586408787960608 0.538461538461538 17.5 17 5 hyperalgesia 0.437714606160953 0.653352834682998 0.586408787960608 0.538461538461538 17.5 17 5 abnormal lens fiber morphology 0.278276808629601 0.547366069120609 0.586408787960608 0.538461538461538 17.5 17 5 short ulna 0.278661045430542 0.547366069120609 0.584365551765623 0.536585365853659 17.5 17 5 abnormal food intake 0.201177522194522 0.477763709142786 0.58398059422164 0.536231884057971 17.5 17 5 abnormal jaw morphology 0.338609653817635 0.618138479158839 0.58341690638938 0.535714285714286 17.5 17 5 abnormal retinal inner nuclear layer morphology 0.338609653817635 0.618138479158839 0.58341690638938 0.535714285714286 17.5 17 5 abnormal axon guidance 0.278913211429405 0.547366069120609 0.582512384053893 0.534883720930233 17.5 17 5 abnormal pain threshold 0.338056120844634 0.618138479158839 0.580823942360983 0.533333333333333 17.5 17 5 absent incisors 0.433304011800193 0.653352834682998 0.580823942360983 0.533333333333333 17.5 17 5 increased alcohol consumption 0.433304011800193 0.653352834682998 0.580823942360983 0.533333333333333 17.5 17 5 abnormal zygomatic bone morphology 0.433304011800193 0.653352834682998 0.580823942360983 0.533333333333333 17.5 17 5 abnormal secondary palate development 0.433304011800193 0.653352834682998 0.580823942360983 0.533333333333333 17.5 17 5 abnormal aorta wall morphology 0.433304011800193 0.653352834682998 0.580823942360983 0.533333333333333 17.5 17 5 ostium primum atrial septal defect 0.433304011800193 0.653352834682998 0.580823942360983 0.533333333333333 17.5 17 5 decreased food intake 0.203034521507544 0.477763709142786 0.578985891910473 0.531645569620253 17.5 17 5 increased dopamine level 0.33737560087777 0.618138479158839 0.578555098836135 0.53125 17.5 17 5 increased susceptibility to pharmacologically induced seizures 0.176136774091255 0.437265694163669 0.578555098836135 0.53125 17.5 17 5 decreased urine osmolality 0.279034585163079 0.547366069120609 0.577860554899957 0.530612244897959 17.5 17 5 abnormal inhibitory postsynaptic currents 0.236665730443474 0.493053605090571 0.576553178078917 0.529411764705882 17.5 17 5 abnormal cued conditioning behavior 0.278904434472448 0.547366069120609 0.576553178078917 0.529411764705882 17.5 17 5 increased susceptibility to weight gain 0.336592596878625 0.618138479158839 0.576553178078917 0.529411764705882 17.5 17 5 abnormal vagus nerve morphology 0.429176233226769 0.653352834682998 0.576553178078917 0.529411764705882 17.5 17 5 increased aggression towards mice 0.429176233226769 0.653352834682998 0.576553178078917 0.529411764705882 17.5 17 5 abnormal touch/ nociception 0.429176233226769 0.653352834682998 0.576553178078917 0.529411764705882 17.5 17 5 decreased growth hormone level 0.429176233226769 0.653352834682998 0.576553178078917 0.529411764705882 17.5 17 5 increased circulating magnesium level 0.429176233226769 0.653352834682998 0.576553178078917 0.529411764705882 17.5 17 5 abnormal survival 0.429176233226769 0.653352834682998 0.576553178078917 0.529411764705882 17.5 17 5 abnormal electroretinogram waveform feature 0.429176233226769 0.653352834682998 0.576553178078917 0.529411764705882 17.5 17 5 abnormal nail morphology 0.425284521027998 0.653352834682998 0.573181522066759 0.526315789473684 17.5 17 5 abnormal ear morphology 0.425284521027998 0.653352834682998 0.573181522066759 0.526315789473684 17.5 17 5 abnormal behavioral response to xenobiotic 0.425284521027998 0.653352834682998 0.573181522066759 0.526315789473684 17.5 17 5 head bobbing 0.333802615905126 0.616631056953646 0.571748568261593 0.525 17.5 17 5 abnormal response/metabolism to endogenous compounds 0.236008706432182 0.491890789484753 0.571084516498222 0.524390243902439 17.5 17 5 hypoalgesia 0.421593792201215 0.653352834682998 0.570452086247394 0.523809523809524 17.5 17 5 abnormal stapes morphology 0.421593792201215 0.653352834682998 0.570452086247394 0.523809523809524 17.5 17 5 decreased vocalization 0.421593792201215 0.653352834682998 0.570452086247394 0.523809523809524 17.5 17 5 abnormal palatal shelf fusion at midline 0.418076920900136 0.653352834682998 0.568197334918353 0.521739130434783 17.5 17 5 abnormal feces composition 0.414712419574276 0.653352834682998 0.566303343801958 0.52 17.5 17 5 diaphragmatic hernia 0.414712419574276 0.653352834682998 0.566303343801958 0.52 17.5 17 5 decreased neuronal precursor cell number 0.405374218580991 0.653352834682998 0.56208768615579 0.516129032258065 17.5 17 5 abnormal middle ear ossicle morphology 0.402473061930488 0.653352834682998 0.561023126144131 0.515151515151515 17.5 17 5 head tossing 0.402473061930488 0.653352834682998 0.561023126144131 0.515151515151515 17.5 17 5 short humerus 0.39170126490344 0.653352834682998 0.557803481230822 0.51219512195122 17.5 17 5 increased food intake 0.307962736701837 0.586118827502539 0.557487266105408 0.511904761904762 17.5 17 5 increased kidney weight 0.379702507308472 0.653352834682998 0.555199356668586 0.509803921568627 17.5 17 5 abnormal long term potentiation 0.473372836284213 0.653352834682998 0.544522445963421 0.5 17.5 17 5 abnormal diaphragm morphology 0.473372836284213 0.653352834682998 0.544522445963421 0.5 17.5 17 5 abnormal tectorial membrane morphology 0.490420230615804 0.668815966917112 0.544522445963421 0.5 17.5 17 5 abnormal basioccipital bone morphology 0.511820115871174 0.69723578216295 0.544522445963421 0.5 17.5 17 5 abnormal fibula morphology 0.511820115871174 0.69723578216295 0.544522445963421 0.5 17.5 17 5 enhanced behavioral response to xenobiotic 0.511820115871174 0.69723578216295 0.544522445963421 0.5 17.5 17 5 abnormal intestinal absorption 0.530098421113933 0.719770645480846 0.544522445963421 0.5 17.5 17 5 abnormal epididymis epithelium morphology 0.530098421113933 0.719770645480846 0.544522445963421 0.5 17.5 17 5 decreased circulating growth hormone level 0.530098421113933 0.719770645480846 0.544522445963421 0.5 17.5 17 5 decreased circulating prolactin level 0.530098421113933 0.719770645480846 0.544522445963421 0.5 17.5 17 5 abnormal intestinal lipid absorption 0.530098421113933 0.719770645480846 0.544522445963421 0.5 17.5 17 5 loose skin 0.530098421113933 0.719770645480846 0.544522445963421 0.5 17.5 17 5 decreased circulating triiodothyronine level 0.530098421113933 0.719770645480846 0.544522445963421 0.5 17.5 17 5 abnormal epidermis suprabasal layer morphology 0.569623203038064 0.763847826176379 0.544522445963421 0.5 17.5 17 5 decreased incidence of induced tumors 0.569623203038064 0.763847826176379 0.544522445963421 0.5 17.5 17 5 decreased circulating parathyroid hormone level 0.569623203038064 0.763847826176379 0.544522445963421 0.5 17.5 17 5 abnormal PNS synaptic transmission 0.569623203038064 0.763847826176379 0.544522445963421 0.5 17.5 17 5 abnormal primordial germ cell migration 0.569623203038064 0.763847826176379 0.544522445963421 0.5 17.5 17 5 rickets 0.569623203038064 0.763847826176379 0.544522445963421 0.5 17.5 17 5 intestinal edema 0.569623203038064 0.763847826176379 0.544522445963421 0.5 17.5 17 5 intestinal hypoperistalsis 0.569623203038064 0.763847826176379 0.544522445963421 0.5 17.5 17 5 increased left ventricle diastolic pressure 0.569623203038064 0.763847826176379 0.544522445963421 0.5 17.5 17 5 abnormal utricular macula morphology 0.569623203038064 0.763847826176379 0.544522445963421 0.5 17.5 17 5 abnormal cochlear inner hair cell physiology 0.569623203038064 0.763847826176379 0.544522445963421 0.5 17.5 17 5 absent coat pigmentation 0.569623203038064 0.763847826176379 0.544522445963421 0.5 17.5 17 5 abnormal gonadal fat pad morphology 0.569623203038064 0.763847826176379 0.544522445963421 0.5 17.5 17 5 decreased thyroxine level 0.569623203038064 0.763847826176379 0.544522445963421 0.5 17.5 17 5 abnormal retinal blood vessel pattern 0.569623203038064 0.763847826176379 0.544522445963421 0.5 17.5 17 5 increased kidney iron level 0.569623203038064 0.763847826176379 0.544522445963421 0.5 17.5 17 5 abnormal pulmonary interalveolar septum morphology 0.569623203038064 0.763847826176379 0.544522445963421 0.5 17.5 17 5 abnormal circadian temperature homeostasis 0.569623203038064 0.763847826176379 0.544522445963421 0.5 17.5 17 5 polyphagia 0.428945392855794 0.653352834682998 0.544522445963421 0.5 17.5 17 5 abnormal vibrissa morphology 0.450635110105718 0.653352834682998 0.544522445963421 0.5 17.5 17 5 abnormal respiration 0.484356191008771 0.660727186802478 0.544522445963421 0.5 17.5 17 5 decreased circulating progesterone level 0.484356191008771 0.660727186802478 0.544522445963421 0.5 17.5 17 5 decreased ovulation rate 0.496954234141251 0.677541056413463 0.544522445963421 0.5 17.5 17 5 abnormal heart shape 0.520429617605418 0.708188552403434 0.544522445963421 0.5 17.5 17 5 decreased activity of thyroid 0.520429617605418 0.708188552403434 0.544522445963421 0.5 17.5 17 5 decreased pulmonary respiratory rate 0.520429617605418 0.708188552403434 0.544522445963421 0.5 17.5 17 5 decreased fluid intake 0.520429617605418 0.708188552403434 0.544522445963421 0.5 17.5 17 5 extended life span 0.541147009185428 0.73317166957993 0.544522445963421 0.5 17.5 17 5 abnormal fluid regulation 0.541147009185428 0.73317166957993 0.544522445963421 0.5 17.5 17 5 decreased vascular permeability 0.541147009185428 0.73317166957993 0.544522445963421 0.5 17.5 17 5 abnormal hair cuticle 0.541147009185428 0.73317166957993 0.544522445963421 0.5 17.5 17 5 increased circulating growth hormone level 0.541147009185428 0.73317166957993 0.544522445963421 0.5 17.5 17 5 increased lung compliance 0.541147009185428 0.73317166957993 0.544522445963421 0.5 17.5 17 5 abnormal respiratory motile cilium physiology 0.541147009185428 0.73317166957993 0.544522445963421 0.5 17.5 17 5 abnormal esophagus morphology 0.554061049222053 0.747208923794988 0.544522445963421 0.5 17.5 17 5 decreased digestive secretion 0.554061049222053 0.747208923794988 0.544522445963421 0.5 17.5 17 5 abnormal enteric nervous system morphology 0.554061049222053 0.747208923794988 0.544522445963421 0.5 17.5 17 5 increased litter size 0.554061049222053 0.747208923794988 0.544522445963421 0.5 17.5 17 5 impaired sperm capacitation 0.554061049222053 0.747208923794988 0.544522445963421 0.5 17.5 17 5 increased placenta weight 0.554061049222053 0.747208923794988 0.544522445963421 0.5 17.5 17 5 hematuria 0.554061049222053 0.747208923794988 0.544522445963421 0.5 17.5 17 5 abnormal anogenital distance 0.554061049222053 0.747208923794988 0.544522445963421 0.5 17.5 17 5 abnormal patella morphology 0.554061049222053 0.747208923794988 0.544522445963421 0.5 17.5 17 5 decreased renal glomerular filtration rate 0.554061049222053 0.747208923794988 0.544522445963421 0.5 17.5 17 5 decreased keratinocyte proliferation 0.554061049222053 0.747208923794988 0.544522445963421 0.5 17.5 17 5 impaired behavioral response to cocaine 0.554061049222053 0.747208923794988 0.544522445963421 0.5 17.5 17 5 decreased oligodendrocyte number 0.554061049222053 0.747208923794988 0.544522445963421 0.5 17.5 17 5 abnormal aorta elastic tissue morphology 0.554061049222053 0.747208923794988 0.544522445963421 0.5 17.5 17 5 increased type II pneumocyte number 0.554061049222053 0.747208923794988 0.544522445963421 0.5 17.5 17 5 abnormal respiratory motile cilium morphology 0.554061049222053 0.747208923794988 0.544522445963421 0.5 17.5 17 5 single kidney 0.540102035675952 0.733153513639253 0.528021765782712 0.484848484848485 17.5 17 5 abnormal cranial ganglia morphology 0.547427790438441 0.741479242426148 0.526957205771053 0.483870967741935 17.5 17 5 abnormal kidney development 0.52205495136648 0.710206011224566 0.526371697764641 0.483333333333333 17.5 17 5 decreased susceptibility to pharmacologically induced seizures 0.563719159661075 0.759821950504972 0.524354947964776 0.481481481481481 17.5 17 5 abnormal palate morphology 0.563719159661075 0.759821950504972 0.524354947964776 0.481481481481481 17.5 17 5 impaired conditioned place preference behavior 0.572869755279998 0.767787454880924 0.522741548124884 0.48 17.5 17 5 abnormal stomach mucosa morphology 0.572869755279998 0.767787454880924 0.522741548124884 0.48 17.5 17 5 abnormal circadian rhythm 0.56645992760674 0.763309355320567 0.519771425692357 0.477272727272727 17.5 17 5 decreased grooming behavior 0.606060204525096 0.804039871336627 0.515863369860083 0.473684210526316 17.5 17 5 abnormal photoreceptor inner segment morphology 0.606060204525096 0.804039871336627 0.515863369860083 0.473684210526316 17.5 17 5 abnormal urinary bladder morphology 0.619807032569191 0.811457891324138 0.512491713847926 0.470588235294118 17.5 17 5 distended urinary bladder 0.619807032569191 0.811457891324138 0.512491713847926 0.470588235294118 17.5 17 5 abnormal heart rate 0.619807032569191 0.811457891324138 0.512491713847926 0.470588235294118 17.5 17 5 decreased chondrocyte number 0.635509631897509 0.831141014376999 0.50822094956586 0.466666666666667 17.5 17 5 decreased aggression towards males 0.635509631897509 0.831141014376999 0.50822094956586 0.466666666666667 17.5 17 5 abnormal Muller cell morphology 0.635509631897509 0.831141014376999 0.50822094956586 0.466666666666667 17.5 17 5 absent corpus callosum 0.632500399159739 0.827858323025441 0.505627985537463 0.464285714285714 17.5 17 5 absent trabeculae carneae 0.653786571845851 0.83539201401924 0.502636103966235 0.461538461538462 17.5 17 5 abnormal sympathetic ganglion morphology 0.653786571845851 0.83539201401924 0.502636103966235 0.461538461538462 17.5 17 5 small seminal vesicle 0.643540776420735 0.83539201401924 0.502636103966235 0.461538461538462 17.5 17 5 pup cannibalization 0.653786571845851 0.83539201401924 0.502636103966235 0.461538461538462 17.5 17 5 abnormal ocular fundus morphology 0.643540776420735 0.83539201401924 0.502636103966235 0.461538461538462 17.5 17 5 anal atresia 0.653786571845851 0.83539201401924 0.502636103966235 0.461538461538462 17.5 17 5 decreased alcohol consumption 0.653786571845851 0.83539201401924 0.502636103966235 0.461538461538462 17.5 17 5 muscle fatigue 0.653786571845851 0.83539201401924 0.502636103966235 0.461538461538462 17.5 17 5 increased percent body fat/body weight 0.649665172027146 0.83539201401924 0.502636103966235 0.461538461538462 17.5 17 5 abnormal malleus morphology 0.65554039180723 0.836019853689046 0.49914557546647 0.458333333333333 17.5 17 5 abnormal tracheal cartilage morphology 0.668673977807034 0.852332318624134 0.495020405421292 0.454545454545455 17.5 17 5 abnormal cochlear sensory epithelium morphology 0.668673977807034 0.852332318624134 0.495020405421292 0.454545454545455 17.5 17 5 increased mast cell number 0.675581949095404 0.858717474897709 0.495020405421292 0.454545454545455 17.5 17 5 secondary sex reversal 0.675581949095404 0.858717474897709 0.495020405421292 0.454545454545455 17.5 17 5 abnormal larynx morphology 0.675581949095404 0.858717474897709 0.495020405421292 0.454545454545455 17.5 17 5 patent ductus arteriosus 0.675581949095404 0.858717474897709 0.495020405421292 0.454545454545455 17.5 17 5 abnormal frequency of paradoxical sleep 0.675581949095404 0.858717474897709 0.495020405421292 0.454545454545455 17.5 17 5 abnormal pituitary gland development 0.675581949095404 0.858717474897709 0.495020405421292 0.454545454545455 17.5 17 5 abnormal crista ampullaris neuroepithelium morphology 0.675581949095404 0.858717474897709 0.495020405421292 0.454545454545455 17.5 17 5 increased motor neuron number 0.675581949095404 0.858717474897709 0.495020405421292 0.454545454545455 17.5 17 5 enhanced behavioral response to addictive substance 0.675581949095404 0.858717474897709 0.495020405421292 0.454545454545455 17.5 17 5 decreased core body temperature 0.675581949095404 0.858717474897709 0.495020405421292 0.454545454545455 17.5 17 5 increased pancreatic beta cell proliferation 0.675581949095404 0.858717474897709 0.495020405421292 0.454545454545455 17.5 17 5 abnormal body temperature homeostasis 0.683924367678499 0.866953327309013 0.491826725386316 0.451612903225806 17.5 17 5 abnormal hearing physiology 0.683165731605576 0.866953327309013 0.490070201367079 0.45 17.5 17 5 nuclear cataracts 0.683165731605576 0.866953327309013 0.490070201367079 0.45 17.5 17 5 decreased retinal photoreceptor cell number 0.695247858399691 0.866953327309013 0.488192537760309 0.448275862068966 17.5 17 5 abnormal reflex 0.717647325961472 0.866953327309013 0.484019951967486 0.444444444444444 17.5 17 5 abnormal single cell response 0.707398069828463 0.866953327309013 0.484019951967486 0.444444444444444 17.5 17 5 abnormal metanephric mesenchyme morphology 0.699308964540209 0.866953327309013 0.484019951967486 0.444444444444444 17.5 17 5 overexpanded pulmonary alveoli 0.728155425645935 0.866953327309013 0.480460981732431 0.441176470588235 17.5 17 5 decreased pancreatic beta cell number 0.728155425645935 0.866953327309013 0.480460981732431 0.441176470588235 17.5 17 5 abnormal inner ear vestibule morphology 0.720495891935769 0.866953327309013 0.479179752447811 0.44 17.5 17 5 abnormal digestive system physiology 0.7542663865699 0.890901062009794 0.479179752447811 0.44 17.5 17 5 increased circulating estradiol level 0.717496129173622 0.866953327309013 0.476457140217994 0.4375 17.5 17 5 abnormal innervation pattern to muscle 0.734688522625017 0.872196890286739 0.473497779098627 0.434782608695652 17.5 17 5 emphysema 0.751046233766544 0.887308243407398 0.471919453168299 0.433333333333333 17.5 17 5 abnormal vasoconstriction 0.738266243841169 0.872416760833685 0.466733525111504 0.428571428571429 17.5 17 5 abnormal zigzag hair morphology 0.738266243841169 0.872416760833685 0.466733525111504 0.428571428571429 17.5 17 5 abnormal pinna reflex 0.738266243841169 0.872416760833685 0.466733525111504 0.428571428571429 17.5 17 5 abnormal endplate potential 0.738266243841169 0.872416760833685 0.466733525111504 0.428571428571429 17.5 17 5 abnormal uterus development 0.738266243841169 0.872416760833685 0.466733525111504 0.428571428571429 17.5 17 5 enlarged stomach 0.738266243841169 0.872416760833685 0.466733525111504 0.428571428571429 17.5 17 5 increased circulating luteinizing hormone level 0.763571322830006 0.900181832009308 0.466733525111504 0.428571428571429 17.5 17 5 abnormal rectum morphology 0.762382591862084 0.898993456865103 0.453768704969518 0.416666666666667 17.5 17 5 abnormal glossopharyngeal nerve morphology 0.762382591862084 0.898993456865103 0.453768704969518 0.416666666666667 17.5 17 5 ear inflammation 0.762382591862084 0.898993456865103 0.453768704969518 0.416666666666667 17.5 17 5 abnormal alisphenoid bone morphology 0.762382591862084 0.898993456865103 0.453768704969518 0.416666666666667 17.5 17 5 absent cochlear hair cells 0.762382591862084 0.898993456865103 0.453768704969518 0.416666666666667 17.5 17 5 small parietal bone 0.762382591862084 0.898993456865103 0.453768704969518 0.416666666666667 17.5 17 5 decreased compensatory feeding amount 0.762382591862084 0.898993456865103 0.453768704969518 0.416666666666667 17.5 17 5 abnormal retinal ganglion layer morphology 0.791222901780579 0.920779868154008 0.453768704969518 0.416666666666667 17.5 17 5 abnormal serotonin level 0.840751468567575 0.971388262147343 0.44242448734528 0.40625 17.5 17 5 decreased skin tensile strength 0.823099919848283 0.956900275791967 0.435617956770737 0.4 17.5 17 5 abnormal male reproductive system physiology 0.823099919848283 0.956900275791967 0.435617956770737 0.4 17.5 17 5 greasy coat 0.806770651803609 0.938653880431 0.435617956770737 0.4 17.5 17 5 impaired behavioral response to xenobiotic 0.864907231879301 0.978157189952153 0.435617956770737 0.4 17.5 17 5 increased susceptibility to age related obesity 0.852776753540157 0.971388262147343 0.426148001188765 0.391304347826087 17.5 17 5 abnormal crista ampullaris morphology 0.852776753540157 0.971388262147343 0.426148001188765 0.391304347826087 17.5 17 5 abnormal stomach glandular epithelium morphology 0.840968199141779 0.971388262147343 0.42351745797155 0.388888888888889 17.5 17 5 small trigeminal ganglion 0.830255104372229 0.961032839518809 0.418863419971863 0.384615384615385 17.5 17 5 increased circulating adrenocorticotropin level 0.830255104372229 0.961032839518809 0.418863419971863 0.384615384615385 17.5 17 5 abnormal insulin secretion 0.830255104372229 0.961032839518809 0.418863419971863 0.384615384615385 17.5 17 5 increased renin activity 0.830255104372229 0.961032839518809 0.418863419971863 0.384615384615385 17.5 17 5 abnormal gut flora balance 0.830255104372229 0.961032839518809 0.418863419971863 0.384615384615385 17.5 17 5 decreased skeletal muscle weight 0.860335365381602 0.973207922413249 0.408391834472566 0.375 17.5 17 5 abnormal urinary bladder physiology 0.860335365381602 0.973207922413249 0.408391834472566 0.375 17.5 17 5 decreased chemically-elicited antinociception 0.884042672652949 0.994597986532886 0.401227065446732 0.368421052631579 17.5 17 5 abnormal kidney medulla morphology 0.881360026889485 0.991804146974708 0.388944604259587 0.357142857142857 17.5 17 5 abnormal squamosal bone morphology 0.881360026889485 0.991804146974708 0.388944604259587 0.357142857142857 17.5 17 5 decreased tongue size 0.881360026889485 0.991804146974708 0.388944604259587 0.357142857142857 17.5 17 5 abnormal renal reabsorbtion 0.881360026889485 0.991804146974708 0.388944604259587 0.357142857142857 17.5 17 5 nephrocalcinosis 0.900948202791535 1 0.384368785385944 0.352941176470588 17.5 17 5 abnormal retinal cone cell morphology 0.929915702286436 1 0.378798223278902 0.347826086956522 17.5 17 5 blistering 0.929915702286436 1 0.378798223278902 0.347826086956522 17.5 17 5 abnormal estrous cycle 0.963606204776092 1 0.363014963975614 0.333333333333333 17.5 17 5 altered righting response 0.918654714432422 1 0.363014963975614 0.333333333333333 17.5 17 5 abnormal rostral migratory stream morphology 0.918654714432422 1 0.363014963975614 0.333333333333333 17.5 17 5 abnormal pituitary gland morphology 0.945163509455522 1 0.340326528727138 0.3125 17.5 17 5 abnormal pancreatic alpha cell morphology 0.945163509455522 1 0.340326528727138 0.3125 17.5 17 5 increased urine calcium level 0.967892708522842 1 0.326713467578053 0.3 17.5 17 5 abnormal tendon morphology 0.96358655389885 1 0.320307321154954 0.294117647058824 17.5 17 5 enlarged pancreas 0.000259218490715914 0.0041870519198431 2.9593837535014 1 17.4 17 4 decreased prostate gland weight 0.000259218490715914 0.0041870519198431 2.9593837535014 1 17.4 17 4 abnormal immature B cell morphology 0.000259218490715914 0.0041870519198431 2.9593837535014 1 17.4 17 4 abnormal vertebral artery origin 0.000259218490715914 0.0041870519198431 2.9593837535014 1 17.4 17 4 ectopic bone 0.000259218490715914 0.0041870519198431 2.9593837535014 1 17.4 17 4 abnormal pineal gland morphology 0.00102679341195762 0.0124482346307232 2.9593837535014 1 17.4 17 4 decreased leukotriene level 0.00102679341195762 0.0124482346307232 2.9593837535014 1 17.4 17 4 increased T follicular helper cell number 0.00102679341195762 0.0124482346307232 2.9593837535014 1 17.4 17 4 aorta hypoplasia 0.00102679341195762 0.0124482346307232 2.9593837535014 1 17.4 17 4 abnormal gas homeostasis 3.22176493210148e-05 0.000718805949617131 2.66344537815126 0.9 17.4 17 4 decreased level of surface class I molecules 0.000115299937764168 0.00216459317123296 2.63056333644569 0.888888888888889 17.4 17 4 abnormal NK cell morphology 0.000407865532390917 0.0060752425857629 2.58946078431373 0.875 17.4 17 4 abnormal macrophage activation involved in immune response 0.000407865532390917 0.0060752425857629 2.58946078431373 0.875 17.4 17 4 abnormal circulating alanine transaminase level 0.00142191865887313 0.0155873729542299 2.53661464585834 0.857142857142857 17.4 17 4 abnormal lymph node primary follicle morphology 0.00142191865887313 0.0155873729542299 2.53661464585834 0.857142857142857 17.4 17 4 decreased mortality induced by ionizing radiation 0.00142191865887313 0.0155873729542299 2.53661464585834 0.857142857142857 17.4 17 4 abnormal MHC II cell surface expression on macrophages 0.00142191865887313 0.0155873729542299 2.53661464585834 0.857142857142857 17.4 17 4 absent popliteal lymph nodes 0.00142191865887313 0.0155873729542299 2.53661464585834 0.857142857142857 17.4 17 4 increased tumor latency 0.00142191865887313 0.0155873729542299 2.53661464585834 0.857142857142857 17.4 17 4 decreased DN2 thymocyte number 0.00142191865887313 0.0155873729542299 2.53661464585834 0.857142857142857 17.4 17 4 decreased DN4 thymocyte number 0.00142191865887313 0.0155873729542299 2.53661464585834 0.857142857142857 17.4 17 4 decreased brain cholesterol level 0.00142191865887313 0.0155873729542299 2.53661464585834 0.857142857142857 17.4 17 4 liver cirrhosis 0.00486466801816614 0.0397401040892883 2.46615312791783 0.833333333333333 17.4 17 4 abnormal leukocyte tethering or rolling 0.00486466801816614 0.0397401040892883 2.46615312791783 0.833333333333333 17.4 17 4 decreased heart right ventricle size 0.00486466801816614 0.0397401040892883 2.46615312791783 0.833333333333333 17.4 17 4 impaired granulocyte bactericidal activity 0.00486466801816614 0.0397401040892883 2.46615312791783 0.833333333333333 17.4 17 4 cerebral arteriovenous malformation 0.00486466801816614 0.0397401040892883 2.46615312791783 0.833333333333333 17.4 17 4 decreased liver cholesterol level 4.25540628791504e-06 0.000120975121613585 2.40449929971989 0.8125 17.4 17 4 abnormal Peyer's patch T cell area morphology 4.45468049526418e-07 1.57177556481839e-05 2.36750700280112 0.8 17.4 17 4 macrocytosis 1.37803361626022e-05 0.000342785862044731 2.36750700280112 0.8 17.4 17 4 increased cranium width 0.00044762909153678 0.00632657593862353 2.36750700280112 0.8 17.4 17 4 decreased transitional stage T2 B cell number 0.00044762909153678 0.00632657593862353 2.36750700280112 0.8 17.4 17 4 abnormal cerebellar granule cell migration 0.00044762909153678 0.00632657593862353 2.36750700280112 0.8 17.4 17 4 acanthocytosis 0.00044762909153678 0.00632657593862353 2.36750700280112 0.8 17.4 17 4 increased B-1 B cell number 4.39760446698611e-05 0.000923125832204891 2.32523009203681 0.785714285714286 17.4 17 4 decreased response to antigen 4.39760446698611e-05 0.000923125832204891 2.32523009203681 0.785714285714286 17.4 17 4 abnormal thymus physiology 0.00143184511358454 0.0155873729542299 2.30174291938998 0.777777777777778 17.4 17 4 short frontal bone 0.00143184511358454 0.0155873729542299 2.30174291938998 0.777777777777778 17.4 17 4 decreased susceptibility to atherosclerosis 0.00143184511358454 0.0155873729542299 2.30174291938998 0.777777777777778 17.4 17 4 abnormal leukopoiesis 0.00143184511358454 0.0155873729542299 2.30174291938998 0.777777777777778 17.4 17 4 absent cervical lymph nodes 0.00143184511358454 0.0155873729542299 2.30174291938998 0.777777777777778 17.4 17 4 decreased transitional stage T1 B cell number 0.00143184511358454 0.0155873729542299 2.30174291938998 0.777777777777778 17.4 17 4 abnormal ductus venosus valve topology 0.00143184511358454 0.0155873729542299 2.30174291938998 0.777777777777778 17.4 17 4 symmetric azygos veins 0.00143184511358454 0.0155873729542299 2.30174291938998 0.777777777777778 17.4 17 4 absent hypoglossal nerve 0.000137984167648299 0.00247823550198661 2.27644904115492 0.769230769230769 17.4 17 4 abnormal vascular endothelial cell development 0.000424494045538582 0.0061391217341699 2.21953781512605 0.75 17.4 17 4 abnormal B cell proliferation 0.000424494045538582 0.0061391217341699 2.21953781512605 0.75 17.4 17 4 decreased mammary gland epithelial cell proliferation 0.000424494045538582 0.0061391217341699 2.21953781512605 0.75 17.4 17 4 increased fibrosarcoma incidence 0.000424494045538582 0.0061391217341699 2.21953781512605 0.75 17.4 17 4 persistent right dorsal aorta 0.000424494045538582 0.0061391217341699 2.21953781512605 0.75 17.4 17 4 abnormal cecum morphology 0.00446407803831976 0.0376420139671878 2.21953781512605 0.75 17.4 17 4 abnormal urination 0.00446407803831976 0.0376420139671878 2.21953781512605 0.75 17.4 17 4 abnormal cellular cholesterol metabolism 0.00446407803831976 0.0376420139671878 2.21953781512605 0.75 17.4 17 4 colon polyps 0.00446407803831976 0.0376420139671878 2.21953781512605 0.75 17.4 17 4 abnormal extraembryonic tissue physiology 0.00446407803831976 0.0376420139671878 2.21953781512605 0.75 17.4 17 4 decreased susceptibility to autoimmune disorder 0.00446407803831976 0.0376420139671878 2.21953781512605 0.75 17.4 17 4 increased caudal vertebrae number 0.00446407803831976 0.0376420139671878 2.21953781512605 0.75 17.4 17 4 pleural effusion 0.00446407803831976 0.0376420139671878 2.21953781512605 0.75 17.4 17 4 absent hypoglossal canal 0.00446407803831976 0.0376420139671878 2.21953781512605 0.75 17.4 17 4 abnormal umbilical vein topology 0.00446407803831976 0.0376420139671878 2.21953781512605 0.75 17.4 17 4 decreased vascular endothelial cell proliferation 0.00446407803831976 0.0376420139671878 2.21953781512605 0.75 17.4 17 4 abnormal physiological neovascularization 4.3434027979283e-06 0.000122775164316439 2.21953781512605 0.75 17.4 17 4 heterochrony 0.000127014243064823 0.00233171903781363 2.17021475256769 0.733333333333333 17.4 17 4 abnormal sphenoid bone morphology 0.0012757898672981 0.014934246093666 2.15227909345556 0.727272727272727 17.4 17 4 abnormal palate development 0.0012757898672981 0.014934246093666 2.15227909345556 0.727272727272727 17.4 17 4 impaired hematopoiesis 1.84918540489344e-12 1.99993421507497e-10 2.14700389959906 0.725490196078431 17.4 17 4 decreased cellular sensitivity to gamma-irradiation 3.83085931726527e-05 0.000827740430393196 2.13733271086212 0.722222222222222 17.4 17 4 decreased B cell proliferation 2.88439149544365e-18 8.96865480614511e-16 2.13525156898202 0.721518987341772 17.4 17 4 increased fibroblast apoptosis 4.12073773017407e-08 1.88079543189138e-06 2.12705707282913 0.71875 17.4 17 4 vascular smooth muscle hypoplasia 0.000373004475094395 0.00560633614379038 2.11384553821529 0.714285714285714 17.4 17 4 spina bifida occulta 0.000373004475094395 0.00560633614379038 2.11384553821529 0.714285714285714 17.4 17 4 testis degeneration 0.000373004475094395 0.00560633614379038 2.11384553821529 0.714285714285714 17.4 17 4 cellular necrosis 0.0134715414163987 0.0887694285385212 2.11384553821529 0.714285714285714 17.4 17 4 broad head 0.0134715414163987 0.0887694285385212 2.11384553821529 0.714285714285714 17.4 17 4 decreased activated T cell number 0.0134715414163987 0.0887694285385212 2.11384553821529 0.714285714285714 17.4 17 4 abnormal tumor incidence 0.0134715414163987 0.0887694285385212 2.11384553821529 0.714285714285714 17.4 17 4 abnormal hypersensitivity reaction 0.0134715414163987 0.0887694285385212 2.11384553821529 0.714285714285714 17.4 17 4 aorta coarctation 0.0134715414163987 0.0887694285385212 2.11384553821529 0.714285714285714 17.4 17 4 atherosclerotic lesions 0.0134715414163987 0.0887694285385212 2.11384553821529 0.714285714285714 17.4 17 4 abnormal uterus physiology 0.0134715414163987 0.0887694285385212 2.11384553821529 0.714285714285714 17.4 17 4 arteritis 0.0134715414163987 0.0887694285385212 2.11384553821529 0.714285714285714 17.4 17 4 abnormal conotruncal ridge morphology 0.0134715414163987 0.0887694285385212 2.11384553821529 0.714285714285714 17.4 17 4 altered tumor pathology 0.0134715414163987 0.0887694285385212 2.11384553821529 0.714285714285714 17.4 17 4 embryonic lethality at implantation, incomplete penetrance 0.0134715414163987 0.0887694285385212 2.11384553821529 0.714285714285714 17.4 17 4 absent connection between subcutaneous lymph vessels and lymph sac 0.0134715414163987 0.0887694285385212 2.11384553821529 0.714285714285714 17.4 17 4 abnormal B cell differentiation 3.00906869789054e-20 1.24750973100045e-17 2.11384553821529 0.714285714285714 17.4 17 4 abnormal T cell proliferation 1.18170747057029e-07 4.8188480869567e-06 2.10020782506551 0.709677419354839 17.4 17 4 abnormal adipose tissue morphology 0.0001107215824623 0.00208651466950735 2.08897676717746 0.705882352941177 17.4 17 4 pancytopenia 0.0001107215824623 0.00208651466950735 2.08897676717746 0.705882352941177 17.4 17 4 decreased circulating fructosamine level 1.08808490166877e-06 3.49240153922719e-05 2.0825293080195 0.703703703703704 17.4 17 4 increased B cell derived lymphoma incidence 3.86637801375758e-11 3.05321120927682e-09 2.07156862745098 0.7 17.4 17 4 peritoneal inflammation 0.00372834916502929 0.0336024222753999 2.07156862745098 0.7 17.4 17 4 increased heart rate variability 0.00372834916502929 0.0336024222753999 2.07156862745098 0.7 17.4 17 4 osteosclerosis 0.00372834916502929 0.0336024222753999 2.07156862745098 0.7 17.4 17 4 absent inguinal lymph nodes 0.00372834916502929 0.0336024222753999 2.07156862745098 0.7 17.4 17 4 absent axillary lymph nodes 0.00372834916502929 0.0336024222753999 2.07156862745098 0.7 17.4 17 4 increased circulating fructosamine level 0.00372834916502929 0.0336024222753999 2.07156862745098 0.7 17.4 17 4 aorta stenosis 0.00372834916502929 0.0336024222753999 2.07156862745098 0.7 17.4 17 4 thin ventricle myocardium compact layer 0.00372834916502929 0.0336024222753999 2.07156862745098 0.7 17.4 17 4 decreased macrophage cytokine production 0.00372834916502929 0.0336024222753999 2.07156862745098 0.7 17.4 17 4 lethality during fetal growth through weaning, complete penetrance 0.00372834916502929 0.0336024222753999 2.07156862745098 0.7 17.4 17 4 absent common myeloid progenitor cells 0.00106914127079172 0.0128623569247047 2.04880413703943 0.692307692307692 17.4 17 4 excessive scratching 0.00106914127079172 0.0128623569247047 2.04880413703943 0.692307692307692 17.4 17 4 increased mortality induced by gamma-irradiation 9.35932809747255e-07 3.02354917434584e-05 2.04095431275959 0.689655172413793 17.4 17 4 abnormal embryonic hematopoiesis 2.87490160518663e-07 1.05166437395614e-05 2.03457633053221 0.6875 17.4 17 4 increased intestinal adenocarcinoma incidence 0.000313264301076774 0.00490091162848098 2.03457633053221 0.6875 17.4 17 4 abnormal lymphocyte physiology 2.22493795800839e-09 1.27230647598756e-07 1.99436731214225 0.673913043478261 17.4 17 4 liver hypoplasia 2.15550465224384e-10 1.45545785895934e-08 1.99189291101056 0.673076923076923 17.4 17 4 abnormal erythropoiesis 4.98153940762686e-19 1.65221057019624e-16 1.97292250233427 0.666666666666667 17.4 17 4 interstitial pneumonia 0.00297838151081713 0.0281459316983279 1.97292250233427 0.666666666666667 17.4 17 4 altered tumor susceptibility 0.00297838151081713 0.0281459316983279 1.97292250233427 0.666666666666667 17.4 17 4 increased osteosarcoma incidence 0.00297838151081713 0.0281459316983279 1.97292250233427 0.666666666666667 17.4 17 4 decreased red blood cell distribution width 0.00297838151081713 0.0281459316983279 1.97292250233427 0.666666666666667 17.4 17 4 abnormal vitelline vein connection 0.00297838151081713 0.0281459316983279 1.97292250233427 0.666666666666667 17.4 17 4 abnormal spleen white pulp morphology 1.92927981481669e-08 9.50313572149805e-07 1.97292250233427 0.666666666666667 17.4 17 4 impaired macrophage chemotaxis 6.23307743388676e-08 2.72013686259532e-06 1.97292250233427 0.666666666666667 17.4 17 4 decreased B-1 B cell number 6.23307743388676e-08 2.72013686259532e-06 1.97292250233427 0.666666666666667 17.4 17 4 abnormal megakaryocyte differentiation 0.000255547561041594 0.0041870519198431 1.97292250233427 0.666666666666667 17.4 17 4 increased gastrointestinal tumor incidence 0.000255547561041594 0.0041870519198431 1.97292250233427 0.666666666666667 17.4 17 4 delayed intramembranous bone ossification 0.000864984939153538 0.010949872957478 1.97292250233427 0.666666666666667 17.4 17 4 decreased thymocyte apoptosis 0.000864984939153538 0.010949872957478 1.97292250233427 0.666666666666667 17.4 17 4 abnormal germ cell morphology 0.0105285438877902 0.0742971714067466 1.97292250233427 0.666666666666667 17.4 17 4 abnormal gut-associated lymphoid tissue morphology 0.0105285438877902 0.0742971714067466 1.97292250233427 0.666666666666667 17.4 17 4 abnormal infrahyoid muscle connection 0.0105285438877902 0.0742971714067466 1.97292250233427 0.666666666666667 17.4 17 4 decreased platelet dense granule number 0.0105285438877902 0.0742971714067466 1.97292250233427 0.666666666666667 17.4 17 4 pale liver 1.40953145716317e-13 1.94789416649632e-11 1.95959194488606 0.662162162162162 17.4 17 4 increased red blood cell distribution width 5.37871683214542e-07 1.83281618081668e-05 1.94473789515806 0.657142857142857 17.4 17 4 abnormal CD8-positive, alpha-beta T cell physiology 5.7029644848904e-06 0.00015589147424357 1.93890659712161 0.655172413793103 17.4 17 4 increased T cell derived lymphoma incidence 4.05785238072664e-09 2.21844127407858e-07 1.93265877779683 0.653061224489796 17.4 17 4 abnormal hematopoietic stem cell physiology 6.15831209895279e-05 0.00126080669515597 1.9300328827183 0.652173913043478 17.4 17 4 increased skin tumor incidence 0.000204378136011635 0.00351827414068471 1.92359943977591 0.65 17.4 17 4 abnormal bone marrow cavity morphology 0.000684592618536641 0.00910654619577484 1.91489536991267 0.647058823529412 17.4 17 4 hyperlipidemia 0.000684592618536641 0.00910654619577484 1.91489536991267 0.647058823529412 17.4 17 4 abnormal spleen periarteriolar lymphoid sheath morphology 0.00232218750304691 0.0230137108120685 1.90246098439376 0.642857142857143 17.4 17 4 increased hemangioma incidence 0.00232218750304691 0.0230137108120685 1.90246098439376 0.642857142857143 17.4 17 4 failure of zygotic cell division 0.00232218750304691 0.0230137108120685 1.90246098439376 0.642857142857143 17.4 17 4 abnormal cytotoxic T cell physiology 1.09092401595489e-07 4.48541072675667e-06 1.90246098439376 0.642857142857143 17.4 17 4 myeloid hyperplasia 3.65976789469878e-06 0.000104639915380037 1.88324420677362 0.636363636363636 17.4 17 4 abnormal vascular branching morphogenesis 0.00016117466747515 0.00285353726223798 1.88324420677362 0.636363636363636 17.4 17 4 abnormal mesenteric lymph node morphology 0.00016117466747515 0.00285353726223798 1.88324420677362 0.636363636363636 17.4 17 4 increased adenoma incidence 0.00016117466747515 0.00285353726223798 1.88324420677362 0.636363636363636 17.4 17 4 abnormal eye distance/ position 0.00802032793605889 0.0597322327573248 1.88324420677362 0.636363636363636 17.4 17 4 abnormal proximal-distal axis patterning 0.00802032793605889 0.0597322327573248 1.88324420677362 0.636363636363636 17.4 17 4 loss of cortex neurons 0.00802032793605889 0.0597322327573248 1.88324420677362 0.636363636363636 17.4 17 4 abnormal pulmonary alveolar sac morphology 0.00802032793605889 0.0597322327573248 1.88324420677362 0.636363636363636 17.4 17 4 hypolactation 0.00802032793605889 0.0597322327573248 1.88324420677362 0.636363636363636 17.4 17 4 increased T cell proliferation 7.07950849439953e-17 1.60093430725626e-14 1.88072986203827 0.635514018691589 17.4 17 4 arrested B cell differentiation 2.80351271704755e-07 1.03314635313419e-05 1.87668238026918 0.634146341463415 17.4 17 4 abnormal nasal septum morphology 0.000533981609906659 0.00739988442697946 1.86908447589562 0.631578947368421 17.4 17 4 abnormal blastocyst morphology 0.000533981609906659 0.00739988442697946 1.86908447589562 0.631578947368421 17.4 17 4 decreased bone marrow cell number 1.0849032110624e-11 9.99517310191746e-10 1.86481715974061 0.63013698630137 17.4 17 4 decreased IgM level 5.61741797017418e-15 9.63677737986778e-13 1.86105576251119 0.628865979381443 17.4 17 4 decreased metastatic potential 0.000125802269027358 0.00231802329041151 1.84961484593838 0.625 17.4 17 4 ocular hypertelorism 0.000125802269027358 0.00231802329041151 1.84961484593838 0.625 17.4 17 4 decreased mast cell number 0.00178451933594815 0.0186062012738792 1.84961484593838 0.625 17.4 17 4 increased cochlear outer hair cell number 0.00178451933594815 0.0186062012738792 1.84961484593838 0.625 17.4 17 4 abnormal level of surface class II molecules 0.00178451933594815 0.0186062012738792 1.84961484593838 0.625 17.4 17 4 abnormal exoccipital bone morphology 0.0284839803798636 0.154365797810263 1.84961484593838 0.625 17.4 17 4 absent pre-B cells 0.0284839803798636 0.154365797810263 1.84961484593838 0.625 17.4 17 4 increased sensitivity to skin irradiation 0.0284839803798636 0.154365797810263 1.84961484593838 0.625 17.4 17 4 abnormal erythrocyte cell number 0.0284839803798636 0.154365797810263 1.84961484593838 0.625 17.4 17 4 abnormal atrial thrombosis 0.0284839803798636 0.154365797810263 1.84961484593838 0.625 17.4 17 4 preneoplasia 0.0284839803798636 0.154365797810263 1.84961484593838 0.625 17.4 17 4 decreased aerobic running capacity 0.0284839803798636 0.154365797810263 1.84961484593838 0.625 17.4 17 4 abnormal soft palate morphology 0.0284839803798636 0.154365797810263 1.84961484593838 0.625 17.4 17 4 liver cysts 0.0284839803798636 0.154365797810263 1.84961484593838 0.625 17.4 17 4 increased cardiac output 0.0284839803798636 0.154365797810263 1.84961484593838 0.625 17.4 17 4 elevated level of mitotic sister chromatid exchange 0.0284839803798636 0.154365797810263 1.84961484593838 0.625 17.4 17 4 binucleate 0.0284839803798636 0.154365797810263 1.84961484593838 0.625 17.4 17 4 abnormal kidney epithelium morphology 0.0284839803798636 0.154365797810263 1.84961484593838 0.625 17.4 17 4 abnormal choroid pigmentation 0.0284839803798636 0.154365797810263 1.84961484593838 0.625 17.4 17 4 abnormal epidermal lamellar body morphology 0.0284839803798636 0.154365797810263 1.84961484593838 0.625 17.4 17 4 abnormal mitotic spindle assembly checkpoint 0.0284839803798636 0.154365797810263 1.84961484593838 0.625 17.4 17 4 abnormal circulating serum amyloid protein level 0.0284839803798636 0.154365797810263 1.84961484593838 0.625 17.4 17 4 delayed suture closure 0.0284839803798636 0.154365797810263 1.84961484593838 0.625 17.4 17 4 abnormal anterior commissure pars posterior morphology 0.0284839803798636 0.154365797810263 1.84961484593838 0.625 17.4 17 4 abnormal maxillary prominence morphology 0.0284839803798636 0.154365797810263 1.84961484593838 0.625 17.4 17 4 decreased cranium length 0.0284839803798636 0.154365797810263 1.84961484593838 0.625 17.4 17 4 increased cardiac stroke volume 0.0284839803798636 0.154365797810263 1.84961484593838 0.625 17.4 17 4 increased testis apoptosis 0.0284839803798636 0.154365797810263 1.84961484593838 0.625 17.4 17 4 embryo cyst 0.0284839803798636 0.154365797810263 1.84961484593838 0.625 17.4 17 4 increased mammary gland apoptosis 0.0284839803798636 0.154365797810263 1.84961484593838 0.625 17.4 17 4 increased brain apoptosis 0.0284839803798636 0.154365797810263 1.84961484593838 0.625 17.4 17 4 extramedullary hematopoiesis 9.0443217720352e-16 1.6665000302176e-13 1.84263516727446 0.622641509433962 17.4 17 4 abnormal T cell activation 2.16417595231325e-11 1.85634057978594e-09 1.83961692785222 0.621621621621622 17.4 17 4 thrombocytopenia 7.8036100191742e-21 3.5293599859447e-18 1.83685888148363 0.620689655172414 17.4 17 4 abnormal embryonic erythropoiesis 3.01120927350273e-05 0.000677862721071317 1.83685888148363 0.620689655172414 17.4 17 4 abnormal hematopoietic system physiology 0.000412324641043918 0.00610510443212348 1.83199946645325 0.619047619047619 17.4 17 4 abnormal erythrocyte physiology 0.000412324641043918 0.00610510443212348 1.83199946645325 0.619047619047619 17.4 17 4 increased leukemia incidence 9.74356611221173e-05 0.0018935250550099 1.82115923292394 0.615384615384615 17.4 17 4 abnormal coping response 0.0060331658948578 0.0474920891248696 1.82115923292394 0.615384615384615 17.4 17 4 abnormal exocrine pancreas morphology 0.0060331658948578 0.0474920891248696 1.82115923292394 0.615384615384615 17.4 17 4 increased prostaglandin level 0.0060331658948578 0.0474920891248696 1.82115923292394 0.615384615384615 17.4 17 4 spleen hyperplasia 4.22483981345492e-11 3.1371012047669e-09 1.81508870214753 0.613333333333333 17.4 17 4 abnormal thymus medulla morphology 0.00135880628031458 0.0154692476992334 1.80851229380641 0.611111111111111 17.4 17 4 abnormal Peyer's patch follicle morphology 0.00135880628031458 0.0154692476992334 1.80851229380641 0.611111111111111 17.4 17 4 abnormal bile duct morphology 0.00135880628031458 0.0154692476992334 1.80851229380641 0.611111111111111 17.4 17 4 absent inner cell mass 0.00135880628031458 0.0154692476992334 1.80851229380641 0.611111111111111 17.4 17 4 decreased lactate dehydrogenase level 0.00135880628031458 0.0154692476992334 1.80851229380641 0.611111111111111 17.4 17 4 increased effector memory CD4-positive, alpha-beta T cell number 0.00135880628031458 0.0154692476992334 1.80851229380641 0.611111111111111 17.4 17 4 increased effector memory CD8-positive, alpha-beta T cell number 0.00135880628031458 0.0154692476992334 1.80851229380641 0.611111111111111 17.4 17 4 abnormal hypoglossal nerve topology 0.00135880628031458 0.0154692476992334 1.80851229380641 0.611111111111111 17.4 17 4 decreased double-positive T cell number 4.25244616105292e-14 6.61122489101196e-12 1.80522408963585 0.61 17.4 17 4 abnormal cell differentiation 1.38411950076452e-06 4.38598376834616e-05 1.80450228872037 0.609756097560976 17.4 17 4 enlarged spleen 2.16519214262216e-37 2.49828136769805e-34 1.79823665577342 0.607638888888889 17.4 17 4 abnormal response to infection 2.59389548160694e-11 2.18722542728721e-09 1.79810658440591 0.607594936708861 17.4 17 4 shortened head 7.50178645906887e-05 0.00149885090899067 1.79676870748299 0.607142857142857 17.4 17 4 lymphoid hyperplasia 7.50178645906887e-05 0.00149885090899067 1.79676870748299 0.607142857142857 17.4 17 4 premature aging 7.50178645906887e-05 0.00149885090899067 1.79676870748299 0.607142857142857 17.4 17 4 increased double-negative T cell number 5.18060330001046e-09 2.74186185293107e-07 1.79503604720577 0.60655737704918 17.4 17 4 overriding aortic valve 2.64041017270781e-07 9.85612912756627e-06 1.78796101774043 0.604166666666667 17.4 17 4 vertebral transformation 2.64041017270781e-07 9.85612912756627e-06 1.78796101774043 0.604166666666667 17.4 17 4 thrombocytosis 1.61961551784032e-08 8.22202775638328e-07 1.78583502366464 0.603448275862069 17.4 17 4 decreased lymphocyte cell number 6.4357887915939e-17 1.52466901134189e-14 1.78025428921569 0.6015625 17.4 17 4 arrested T cell differentiation 5.74899960614645e-05 0.00118677481496177 1.77563025210084 0.6 17.4 17 4 ruffled hair 0.000241042109403633 0.00401065048255209 1.77563025210084 0.6 17.4 17 4 abnormal lymph node B cell domain morphology 0.00450799134888696 0.0376928688415338 1.77563025210084 0.6 17.4 17 4 abnormal placenta size 0.00450799134888696 0.0376928688415338 1.77563025210084 0.6 17.4 17 4 immune system phenotype 0.00450799134888696 0.0376928688415338 1.77563025210084 0.6 17.4 17 4 abnormal dendritic cell morphology 0.00450799134888696 0.0376928688415338 1.77563025210084 0.6 17.4 17 4 decreased brown adipose tissue mass 0.00450799134888696 0.0376928688415338 1.77563025210084 0.6 17.4 17 4 increased mammary adenocarcinoma incidence 0.0010283868207492 0.0124482346307232 1.77563025210084 0.6 17.4 17 4 abnormal thymocyte activation 0.0010283868207492 0.0124482346307232 1.77563025210084 0.6 17.4 17 4 absent ductus venosus valve 0.0010283868207492 0.0124482346307232 1.77563025210084 0.6 17.4 17 4 kidney hemorrhage 0.0207288359719316 0.11991390576786 1.77563025210084 0.6 17.4 17 4 abnormal mammary gland physiology 0.0207288359719316 0.11991390576786 1.77563025210084 0.6 17.4 17 4 ketoaciduria 0.0207288359719316 0.11991390576786 1.77563025210084 0.6 17.4 17 4 absent CD4-positive, alpha beta T cells 0.0207288359719316 0.11991390576786 1.77563025210084 0.6 17.4 17 4 abnormal reproductive system development 0.0207288359719316 0.11991390576786 1.77563025210084 0.6 17.4 17 4 increased T-helper 17 cell number 0.0207288359719316 0.11991390576786 1.77563025210084 0.6 17.4 17 4 abnormal inferior vena cava valve morphology 0.0207288359719316 0.11991390576786 1.77563025210084 0.6 17.4 17 4 thymus hypoplasia 1.82810990355664e-17 5.34990986482017e-15 1.75847440425446 0.594202898550725 17.4 17 4 increased B cell proliferation 3.01306777285695e-08 1.41415209150598e-06 1.75556663343303 0.593220338983051 17.4 17 4 abnormal atrioventricular cushion morphology 0.000183080066949081 0.00318287248041194 1.75370889096379 0.592592592592593 17.4 17 4 decreased B cell number 4.46506576695072e-25 2.77671277382248e-22 1.75264474721928 0.592233009708738 17.4 17 4 abnormal CD4-positive, alpha-beta T cell physiology 1.44449605552716e-09 8.35624171656701e-08 1.75062137531069 0.591549295774648 17.4 17 4 abnormal myelopoiesis 1.99156122744618e-06 6.07853810217469e-05 1.74872676343265 0.590909090909091 17.4 17 4 decreased blood urea nitrogen level 1.99156122744618e-06 6.07853810217469e-05 1.74872676343265 0.590909090909091 17.4 17 4 abnormal abdominal fat pad morphology 0.000775096825087693 0.00998991374303438 1.74872676343265 0.590909090909091 17.4 17 4 abnormal germ layer development 0.000775096825087693 0.00998991374303438 1.74872676343265 0.590909090909091 17.4 17 4 embryonic lethality before implantation, incomplete penetrance 0.000775096825087693 0.00998991374303438 1.74872676343265 0.590909090909091 17.4 17 4 impaired humoral immune response 0.000775096825087693 0.00998991374303438 1.74872676343265 0.590909090909091 17.4 17 4 small liver 2.78806804365034e-10 1.82508401541585e-08 1.74527759821877 0.58974358974359 17.4 17 4 increased autoantibody level 8.12932761785232e-06 0.000216120545068419 1.74527759821877 0.58974358974359 17.4 17 4 increased tumor incidence 2.07816072056294e-15 3.69244628028594e-13 1.74221785488389 0.588709677419355 17.4 17 4 abnormal direction of heart looping 3.34160441784924e-05 0.000735596547734511 1.74081397264788 0.588235294117647 17.4 17 4 decreased cytotoxic T cell cytolysis 3.34160441784924e-05 0.000735596547734511 1.74081397264788 0.588235294117647 17.4 17 4 increased regulatory T cell number 0.00335584321796458 0.0309172592766182 1.74081397264788 0.588235294117647 17.4 17 4 increased brain size 0.00335584321796458 0.0309172592766182 1.74081397264788 0.588235294117647 17.4 17 4 abnormal immune system morphology 1.52315938151968e-06 4.73607370191275e-05 1.73702959444647 0.58695652173913 17.4 17 4 abnormal nursing 0.000582504465515049 0.0078748905324385 1.72630718954248 0.583333333333333 17.4 17 4 small lymph nodes 0.000582504465515049 0.0078748905324385 1.72630718954248 0.583333333333333 17.4 17 4 increased hemangiosarcoma incidence 0.000582504465515049 0.0078748905324385 1.72630718954248 0.583333333333333 17.4 17 4 abnormal supraoccipital bone morphology 0.0150790529313973 0.0974263484853267 1.72630718954248 0.583333333333333 17.4 17 4 abnormal respiratory function 0.0150790529313973 0.0974263484853267 1.72630718954248 0.583333333333333 17.4 17 4 loss of dopaminergic neurons 0.0150790529313973 0.0974263484853267 1.72630718954248 0.583333333333333 17.4 17 4 small intestinal inflammation 0.0150790529313973 0.0974263484853267 1.72630718954248 0.583333333333333 17.4 17 4 abnormal defecation 0.0150790529313973 0.0974263484853267 1.72630718954248 0.583333333333333 17.4 17 4 pale placenta 0.0150790529313973 0.0974263484853267 1.72630718954248 0.583333333333333 17.4 17 4 decreased keratinocyte proliferation 0.0150790529313973 0.0974263484853267 1.72630718954248 0.583333333333333 17.4 17 4 abnormal pulmonary valve cusp morphology 0.0150790529313973 0.0974263484853267 1.72630718954248 0.583333333333333 17.4 17 4 abnormal cell cycle 5.87755305322063e-14 8.86085649690079e-12 1.72416270856169 0.582608695652174 17.4 17 4 abnormal definitive hematopoiesis 1.8784870115089e-11 1.63955664600996e-09 1.71835185687178 0.580645161290323 17.4 17 4 decreased tumor incidence 0.00249294020212546 0.024270797466877 1.71332743623765 0.578947368421053 17.4 17 4 increased susceptibility to ischemic brain injury 0.00249294020212546 0.024270797466877 1.71332743623765 0.578947368421053 17.4 17 4 decreased susceptibility to weight gain 0.00249294020212546 0.024270797466877 1.71332743623765 0.578947368421053 17.4 17 4 decreased susceptibility to induced arthritis 1.67703387465118e-07 6.67459482111171e-06 1.71332743623765 0.578947368421053 17.4 17 4 abnormal leukocyte migration 6.74025310818797e-07 2.26572697386724e-05 1.70733678086619 0.576923076923077 17.4 17 4 abnormal leukocyte cell number 0.000436869084332973 0.00624547038665672 1.70733678086619 0.576923076923077 17.4 17 4 pulmonary edema 0.000436869084332973 0.00624547038665672 1.70733678086619 0.576923076923077 17.4 17 4 increased thymocyte apoptosis 0.000436869084332973 0.00624547038665672 1.70733678086619 0.576923076923077 17.4 17 4 abnormal T cell subpopulation ratio 7.89751640054187e-05 0.001570417799599 1.70388761565232 0.575757575757576 17.4 17 4 increased spleen weight 3.1639733887533e-13 4.03609425873017e-11 1.70230038918222 0.575221238938053 17.4 17 4 abnormal cell adhesion 5.12149389097486e-07 1.79432620476056e-05 1.69890548812117 0.574074074074074 17.4 17 4 pericardial edema 1.85432045487e-08 9.22524426297827e-07 1.69729362333169 0.573529411764706 17.4 17 4 abnormal blood flow velocity 0.010981137083939 0.0765142254798271 1.69107643057223 0.571428571428571 17.4 17 4 abnormal vascular endothelial cell migration 0.010981137083939 0.0765142254798271 1.69107643057223 0.571428571428571 17.4 17 4 abnormal maternal decidual layer morphology 0.010981137083939 0.0765142254798271 1.69107643057223 0.571428571428571 17.4 17 4 increased stomach tumor incidence 0.010981137083939 0.0765142254798271 1.69107643057223 0.571428571428571 17.4 17 4 abnormal vitelline vein topology 0.010981137083939 0.0765142254798271 1.69107643057223 0.571428571428571 17.4 17 4 increased incidence of induced tumors 0.00184980306035623 0.0190139880687443 1.69107643057223 0.571428571428571 17.4 17 4 liver degeneration 0.00184980306035623 0.0190139880687443 1.69107643057223 0.571428571428571 17.4 17 4 absent segment of posterior cerebral artery 0.00184980306035623 0.0190139880687443 1.69107643057223 0.571428571428571 17.4 17 4 dermatitis 2.94700593598137e-07 1.06241699503676e-05 1.68378730802666 0.568965517241379 17.4 17 4 decreased T cell proliferation 3.50394411799698e-16 6.97284879481399e-14 1.67965023847377 0.567567567567568 17.4 17 4 abnormal spleen marginal zone morphology 0.000244746254503182 0.00404522463838316 1.67698412698413 0.566666666666667 17.4 17 4 abnormal cellular respiration 0.000244746254503182 0.00404522463838316 1.67698412698413 0.566666666666667 17.4 17 4 decreased T cell number 3.01328227351675e-17 8.32837739485879e-15 1.67269516502253 0.565217391304348 17.4 17 4 perimembraneous ventricular septal defect 3.22518880142349e-08 1.49956208290484e-06 1.67269516502253 0.565217391304348 17.4 17 4 abnormal B cell morphology 0.00137179939153531 0.0155815113536259 1.67269516502253 0.565217391304348 17.4 17 4 increased B cell number 7.30819271211443e-13 8.07961305394873e-11 1.66939596351361 0.564102564102564 17.4 17 4 abnormal T-helper 2 physiology 8.89686598355073e-07 2.91196764922137e-05 1.66801629742806 0.563636363636364 17.4 17 4 sepsis 0.00800959822266545 0.0597322327573248 1.66465336134454 0.5625 17.4 17 4 blepharitis 0.00800959822266545 0.0597322327573248 1.66465336134454 0.5625 17.4 17 4 dystonia 0.00800959822266545 0.0597322327573248 1.66465336134454 0.5625 17.4 17 4 spleen hypoplasia 1.47436730236797e-11 1.30981738022869e-09 1.66289182339603 0.561904761904762 17.4 17 4 abnormal cell morphology 2.17117097277752e-12 2.29820757224855e-10 1.66140842301833 0.56140350877193 17.4 17 4 increased hepatocellular carcinoma incidence 6.7157105148889e-07 2.26572697386724e-05 1.66140842301833 0.56140350877193 17.4 17 4 liver fibrosis 2.52322296322877e-05 0.000581158992688109 1.66014210562274 0.560975609756098 17.4 17 4 decreased mean corpuscular hemoglobin 7.29536602824794e-08 3.12883155090806e-06 1.65377327401549 0.558823529411765 17.4 17 4 enlarged liver sinusoidal spaces 0.00013668338245286 0.00246376749167745 1.65377327401549 0.558823529411765 17.4 17 4 kinked neural tube 2.67230786689256e-06 8.05741311381242e-05 1.65042555483732 0.557692307692308 17.4 17 4 increased brain weight 0.000754105356062832 0.00984691377011178 1.64410208527856 0.555555555555556 17.4 17 4 thick interventricular septum 0.000754105356062832 0.00984691377011178 1.64410208527856 0.555555555555556 17.4 17 4 abnormal mitral valve morphology 0.00585213939002709 0.0463604991487019 1.64410208527856 0.555555555555556 17.4 17 4 abnormal redox activity 0.00585213939002709 0.0463604991487019 1.64410208527856 0.555555555555556 17.4 17 4 small thoracic cage 0.00585213939002709 0.0463604991487019 1.64410208527856 0.555555555555556 17.4 17 4 decreased tumor latency 0.00585213939002709 0.0463604991487019 1.64410208527856 0.555555555555556 17.4 17 4 abnormal aerobic respiration 0.00585213939002709 0.0463604991487019 1.64410208527856 0.555555555555556 17.4 17 4 impaired leukocyte tethering or rolling 0.00585213939002709 0.0463604991487019 1.64410208527856 0.555555555555556 17.4 17 4 heart hyperplasia 0.0509282759949553 0.239468002514514 1.64410208527856 0.555555555555556 17.4 17 4 synostosis 0.0509282759949553 0.239468002514514 1.64410208527856 0.555555555555556 17.4 17 4 dilated uterus 0.0509282759949553 0.239468002514514 1.64410208527856 0.555555555555556 17.4 17 4 multifocal hepatic necrosis 0.0509282759949553 0.239468002514514 1.64410208527856 0.555555555555556 17.4 17 4 increased pheochromocytoma incidence 0.0509282759949553 0.239468002514514 1.64410208527856 0.555555555555556 17.4 17 4 abnormal vomeronasal organ morphology 0.0509282759949553 0.239468002514514 1.64410208527856 0.555555555555556 17.4 17 4 decreased cellular sensitivity to ionizing radiation 0.0509282759949553 0.239468002514514 1.64410208527856 0.555555555555556 17.4 17 4 eye opacity 0.0509282759949553 0.239468002514514 1.64410208527856 0.555555555555556 17.4 17 4 abnormal ventricle myocardium morphology 0.0509282759949553 0.239468002514514 1.64410208527856 0.555555555555556 17.4 17 4 abnormal oxidative phosphorylation 0.0509282759949553 0.239468002514514 1.64410208527856 0.555555555555556 17.4 17 4 increased myeloid cell number 0.0509282759949553 0.239468002514514 1.64410208527856 0.555555555555556 17.4 17 4 increased cardiac muscle glycogen level 0.0509282759949553 0.239468002514514 1.64410208527856 0.555555555555556 17.4 17 4 cerebellum atrophy 0.0509282759949553 0.239468002514514 1.64410208527856 0.555555555555556 17.4 17 4 abnormal T cell differentiation 9.76599158733846e-11 7.04142147058099e-09 1.64084643758493 0.554455445544555 17.4 17 4 decreased monocyte cell number 2.16784314903095e-07 8.42579661439762e-06 1.63904330963155 0.553846153846154 17.4 17 4 abnormal cell nucleus morphology 1.06460372947099e-05 0.000270224671128479 1.63710590619226 0.553191489361702 17.4 17 4 neuron degeneration 1.06460372947099e-05 0.000270224671128479 1.63710590619226 0.553191489361702 17.4 17 4 abnormal T-helper 1 physiology 1.06460372947099e-05 0.000270224671128479 1.63710590619226 0.553191489361702 17.4 17 4 double outlet right ventricle 4.21362592768163e-11 3.1371012047669e-09 1.63180973323909 0.551401869158878 17.4 17 4 abnormal dendritic cell physiology 4.21362592768163e-11 3.1371012047669e-09 1.63180973323909 0.551401869158878 17.4 17 4 increased lymphocyte cell number 1.22846155320974e-07 4.9687774205028e-06 1.62980554540657 0.550724637681159 17.4 17 4 increased monocyte cell number 2.16490214196967e-10 1.45545785895934e-08 1.62766106442577 0.55 17.4 17 4 decreased myocardial infarction size 0.00428294989047421 0.0368008215977706 1.62766106442577 0.55 17.4 17 4 inner cell mass degeneration 0.000414763284657493 0.00611027056447055 1.62288786482335 0.548387096774194 17.4 17 4 increased inflammatory response 8.38987540644329e-10 5.09019879842139e-08 1.61987321244287 0.547368421052632 17.4 17 4 increased mean corpuscular hemoglobin 4.76135951309161e-10 2.96097044720385e-08 1.61420932009167 0.545454545454545 17.4 17 4 decreased brown adipose tissue amount 0.000307722442531991 0.00486006079871954 1.61420932009167 0.545454545454545 17.4 17 4 increased activated T cell number 0.00313945054267848 0.0291939559809821 1.61420932009167 0.545454545454545 17.4 17 4 increased skin papilloma incidence 0.00313945054267848 0.0291939559809821 1.61420932009167 0.545454545454545 17.4 17 4 abnormal occipital bone morphology 0.00313945054267848 0.0291939559809821 1.61420932009167 0.545454545454545 17.4 17 4 increased mammary gland tumor incidence 0.00313945054267848 0.0291939559809821 1.61420932009167 0.545454545454545 17.4 17 4 abnormal hemoglobin 0.0359790456149788 0.18684316485858 1.61420932009167 0.545454545454545 17.4 17 4 vasculitis 0.0359790456149788 0.18684316485858 1.61420932009167 0.545454545454545 17.4 17 4 pharyngeal arch hypoplasia 0.0359790456149788 0.18684316485858 1.61420932009167 0.545454545454545 17.4 17 4 palatal shelf hypoplasia 0.0359790456149788 0.18684316485858 1.61420932009167 0.545454545454545 17.4 17 4 increased number of Howell-Jolly bodies 0.0359790456149788 0.18684316485858 1.61420932009167 0.545454545454545 17.4 17 4 absent vitelline blood vessels 2.51166574119416e-06 7.61922991612254e-05 1.60948940979901 0.543859649122807 17.4 17 4 abnormal cell death 2.365306428221e-05 0.000549878480392499 1.60836073559859 0.543478260869565 17.4 17 4 failure to gastrulate 2.365306428221e-05 0.000549878480392499 1.60836073559859 0.543478260869565 17.4 17 4 abnormal liver development 0.000228379042612574 0.00386457733672638 1.60652260904362 0.542857142857143 17.4 17 4 pale yolk sac 1.66830496712959e-08 8.38365374895928e-07 1.604485167561 0.542168674698795 17.4 17 4 hemolytic anemia 0.00230460248592287 0.0229767482313954 1.60299953314659 0.541666666666667 17.4 17 4 abnormal tumor morphology 0.00230460248592287 0.0229767482313954 1.60299953314659 0.541666666666667 17.4 17 4 increased osteoclast cell number 1.4080637486838e-06 4.43361844917841e-05 1.6009780961565 0.540983606557377 17.4 17 4 abnormal calcium ion homeostasis 0.000169550418727603 0.00299118203251711 1.59966689378454 0.540540540540541 17.4 17 4 abnormal spleen morphology 4.83878728940671e-16 9.2588333710763e-14 1.59874754499501 0.540229885057471 17.4 17 4 decreased leukocyte cell number 6.09124409287927e-13 6.88725894592599e-11 1.59849925371609 0.54014598540146 17.4 17 4 abnormal cytokine secretion 2.90647154590747e-14 4.81989864696322e-12 1.59499254247153 0.538961038961039 17.4 17 4 heart inflammation 0.00169402072556502 0.0179313895950765 1.59351432880845 0.538461538461538 17.4 17 4 abnormal mast cell morphology 0.0256325878073601 0.143767896664731 1.59351432880845 0.538461538461538 17.4 17 4 tight skin 0.0256325878073601 0.143767896664731 1.59351432880845 0.538461538461538 17.4 17 4 abnormal grip strength 0.0256325878073601 0.143767896664731 1.59351432880845 0.538461538461538 17.4 17 4 increased pituitary adenoma incidence 0.0256325878073601 0.143767896664731 1.59351432880845 0.538461538461538 17.4 17 4 lymphoid hypoplasia 0.0256325878073601 0.143767896664731 1.59351432880845 0.538461538461538 17.4 17 4 abnormal otolith morphology 0.0256325878073601 0.143767896664731 1.59351432880845 0.538461538461538 17.4 17 4 increased circulating ammonia level 0.0256325878073601 0.143767896664731 1.59351432880845 0.538461538461538 17.4 17 4 orthokeratosis 0.0256325878073601 0.143767896664731 1.59351432880845 0.538461538461538 17.4 17 4 abnormal aorta tunica media morphology 0.0256325878073601 0.143767896664731 1.59351432880845 0.538461538461538 17.4 17 4 decreased cardiac stroke volume 0.0256325878073601 0.143767896664731 1.59351432880845 0.538461538461538 17.4 17 4 increased leukocyte cell number 1.95515283772232e-13 2.62888793720771e-11 1.59194436395248 0.537931034482759 17.4 17 4 decreased tumor growth/size 7.34148951136964e-06 0.000199584209393792 1.58929868243594 0.537037037037037 17.4 17 4 embryonic lethality before implantation, complete penetrance 1.17780968370053e-11 1.06538239571093e-09 1.58622969187675 0.536 17.4 17 4 abnormal brainstem morphology 0.00124673114756579 0.0147327493091207 1.58538415366146 0.535714285714286 17.4 17 4 decreased erythrocyte cell number 3.54256579838152e-14 5.68524672482196e-12 1.58336455601349 0.535031847133758 17.4 17 4 abnormal vasculogenesis 6.95209319964228e-05 0.00141170055788655 1.58292619373331 0.534883720930233 17.4 17 4 abnormal humoral immune response 7.13227974676693e-10 4.38062860989697e-08 1.57833800186741 0.533333333333333 17.4 17 4 gastrointestinal hemorrhage 0.000918571935051623 0.0114533718718843 1.57833800186741 0.533333333333333 17.4 17 4 abnormal fat pad morphology 0.000918571935051623 0.0114533718718843 1.57833800186741 0.533333333333333 17.4 17 4 abnormal prostate gland morphology 0.0183790179239985 0.108981661706665 1.57833800186741 0.533333333333333 17.4 17 4 increased airway responsiveness 0.0183790179239985 0.108981661706665 1.57833800186741 0.533333333333333 17.4 17 4 abnormal energy homeostasis 0.0183790179239985 0.108981661706665 1.57833800186741 0.533333333333333 17.4 17 4 liver vascular congestion 0.0183790179239985 0.108981661706665 1.57833800186741 0.533333333333333 17.4 17 4 ostium primum atrial septal defect 0.0183790179239985 0.108981661706665 1.57833800186741 0.533333333333333 17.4 17 4 abnormal microglial cell activation 0.0183790179239985 0.108981661706665 1.57833800186741 0.533333333333333 17.4 17 4 decreased trabecular bone mass 0.0183790179239985 0.108981661706665 1.57833800186741 0.533333333333333 17.4 17 4 increased cellular sensitivity to gamma-irradiation 3.84337767680057e-05 0.000827740430393196 1.57414029441564 0.531914893617021 17.4 17 4 increased respiratory quotient 3.84337767680057e-05 0.000827740430393196 1.57414029441564 0.531914893617021 17.4 17 4 decreased susceptibility to parasitic infection 0.000677483647610096 0.00906043319048448 1.57217261904762 0.53125 17.4 17 4 increased neuron apoptosis 7.77906254717551e-08 3.27973187899984e-06 1.5710308814884 0.530864197530864 17.4 17 4 increased sarcoma incidence 2.85901010320718e-05 0.000651965555660997 1.57028525695993 0.530612244897959 17.4 17 4 abnormal spleen red pulp morphology 0.000500141385121018 0.00700902363655512 1.56673257538309 0.529411764705882 17.4 17 4 increased susceptibility to viral infection induced morbidity/mortality 0.000500141385121018 0.00700902363655512 1.56673257538309 0.529411764705882 17.4 17 4 abnormal dorsal-ventral axis patterning 0.0132450726029539 0.0887694285385212 1.56673257538309 0.529411764705882 17.4 17 4 abnormal embryonic-extraembryonic boundary morphology 0.0132450726029539 0.0887694285385212 1.56673257538309 0.529411764705882 17.4 17 4 abnormal melanosome morphology 0.0132450726029539 0.0887694285385212 1.56673257538309 0.529411764705882 17.4 17 4 abnormal circulating chemokine level 0.0132450726029539 0.0887694285385212 1.56673257538309 0.529411764705882 17.4 17 4 embryonic lethality between somite formation and embryo turning, complete penetrance 7.10052106547132e-07 2.3708115638067e-05 1.56424569827931 0.528571428571429 17.4 17 4 atrioventricular septal defect 1.5834491416968e-05 0.00038056325990056 1.56344802071772 0.528301886792453 17.4 17 4 abnormal inflammatory response 5.30478371804012e-07 1.83160001557536e-05 1.56189698101463 0.527777777777778 17.4 17 4 heart right ventricle hypertrophy 0.000369540379009516 0.00560633614379038 1.56189698101463 0.527777777777778 17.4 17 4 abnormal trophoblast giant cell morphology 0.000369540379009516 0.00560633614379038 1.56189698101463 0.527777777777778 17.4 17 4 decreased circulating calcium level 1.17890750292839e-05 0.000296215395306502 1.56040234275528 0.527272727272727 17.4 17 4 abnormal triglyceride level 0.00958458293214002 0.0684121952473409 1.55757039657968 0.526315789473684 17.4 17 4 stereotypic behavior 0.00958458293214002 0.0684121952473409 1.55757039657968 0.526315789473684 17.4 17 4 abnormal long term depression 0.00958458293214002 0.0684121952473409 1.55757039657968 0.526315789473684 17.4 17 4 increased malignant tumor incidence 0.00958458293214002 0.0684121952473409 1.55757039657968 0.526315789473684 17.4 17 4 increased liver adenoma incidence 0.00958458293214002 0.0684121952473409 1.55757039657968 0.526315789473684 17.4 17 4 increased circulating VLDL cholesterol level 0.00958458293214002 0.0684121952473409 1.55757039657968 0.526315789473684 17.4 17 4 Leydig cell hypoplasia 0.00958458293214002 0.0684121952473409 1.55757039657968 0.526315789473684 17.4 17 4 increased liver cholesterol level 0.00958458293214002 0.0684121952473409 1.55757039657968 0.526315789473684 17.4 17 4 increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 0.00958458293214002 0.0684121952473409 1.55757039657968 0.526315789473684 17.4 17 4 liver inflammation 1.51549758979566e-10 1.06191556468076e-08 1.55367647058824 0.525 17.4 17 4 abnormal NK cell physiology 4.87272625607788e-06 0.000134676739577708 1.55246360839418 0.524590163934426 17.4 17 4 left pulmonary isomerism 0.006959411403604 0.0533483385715407 1.55015339469121 0.523809523809524 17.4 17 4 embryonic lethality at implantation, complete penetrance 0.006959411403604 0.0533483385715407 1.55015339469121 0.523809523809524 17.4 17 4 increased muscle cell glucose uptake 0.006959411403604 0.0533483385715407 1.55015339469121 0.523809523809524 17.4 17 4 decreased spleen weight 1.50501238039601e-06 4.70907961790576e-05 1.54402630617464 0.521739130434783 17.4 17 4 embryonic lethality between implantation and placentation, complete penetrance 8.22603884387869e-05 0.00161757087937931 1.54402630617464 0.521739130434783 17.4 17 4 pancreas inflammation 0.0050677972530165 0.0410623637357608 1.54402630617464 0.521739130434783 17.4 17 4 anemia 5.17931125602334e-17 1.28835367493581e-14 1.54280669613817 0.52132701421801 17.4 17 4 increased pre-B cell number 0.00369940451702925 0.0336024222753999 1.53887955182073 0.52 17.4 17 4 decreased IgA level 3.36280445806128e-05 0.000737002298627967 1.53660310277957 0.519230769230769 17.4 17 4 abnormal maxilla morphology 2.49808011614583e-05 0.000578044119898861 1.53449527959332 0.518518518518518 17.4 17 4 decreased birth body size 1.18493536671568e-09 6.93535699930646e-08 1.53161088997002 0.517543859649123 17.4 17 4 increased neutrophil cell number 7.42341508038749e-12 6.96820566508071e-10 1.53071573456969 0.517241379310345 17.4 17 4 increased eosinophil cell number 7.63678952512536e-06 0.000205367718310803 1.52742387277492 0.516129032258065 17.4 17 4 decreased double-negative T cell number 0.00145596782880536 0.0158153710661717 1.52742387277492 0.516129032258065 17.4 17 4 abnormal QRS complex 0.00107035492800557 0.0128623569247047 1.52453102453102 0.515151515151515 17.4 17 4 pallor 9.7295362445741e-14 1.38298408047875e-11 1.52196878751501 0.514285714285714 17.4 17 4 increased carcinoma incidence 0.000787889747777011 0.010076481992778 1.52196878751501 0.514285714285714 17.4 17 4 increased circulating serum albumin level 0.000787889747777011 0.010076481992778 1.52196878751501 0.514285714285714 17.4 17 4 holoprosencephaly 0.000787889747777011 0.010076481992778 1.52196878751501 0.514285714285714 17.4 17 4 increased granulocyte number 1.30296768300017e-06 4.1552975787986e-05 1.51968354909531 0.513513513513513 17.4 17 4 increased circulating phosphate level 0.000580640892640427 0.0078748905324385 1.51968354909531 0.513513513513513 17.4 17 4 increased erythroid progenitor cell number 0.000580640892640427 0.0078748905324385 1.51968354909531 0.513513513513513 17.4 17 4 increased oxygen consumption 2.24168720258245e-07 8.57876448680591e-06 1.5141033157449 0.511627906976744 17.4 17 4 impaired macrophage phagocytosis 0.000233778341848346 0.00392557139263439 1.5141033157449 0.511627906976744 17.4 17 4 abnormal cell migration 0.000172916482275469 0.00303978621668007 1.51257391845627 0.511111111111111 17.4 17 4 decreased hemoglobin content 4.21939180412341e-11 3.1371012047669e-09 1.51117468263901 0.51063829787234 17.4 17 4 abnormal embryo turning 3.86611097429726e-05 0.00082904750418659 1.50659536541889 0.509090909090909 17.4 17 4 increased macrophage cell number 2.86995892843735e-05 0.000651965555660997 1.50565138336036 0.508771929824561 17.4 17 4 decreased cell proliferation 7.21131141333862e-14 1.05518453768705e-11 1.50368688015747 0.508108108108108 17.4 17 4 abnormal neural tube morphology 3.54902286761441e-12 3.60334464620034e-10 1.49795967769824 0.506172839506173 17.4 17 4 decreased IgG level 1.02751488758652e-08 5.38093322709783e-07 1.4930224341989 0.504504504504504 17.4 17 4 embryonic lethality between implantation and somite formation, complete penetrance 3.73922934587988e-17 9.79087683986969e-15 1.48573143543132 0.502040816326531 17.4 17 4 embryonic lethality during organogenesis, complete penetrance 2.51083554542518e-37 2.49828136769805e-34 1.48497649059624 0.501785714285714 17.4 17 4 subcutaneous edema 0.00416574340710738 0.035855663408926 1.4796918767507 0.5 17.4 17 4 increased aggression towards males 0.0402840385307812 0.199614633158004 1.4796918767507 0.5 17.4 17 4 absent visceral yolk sac blood islands 0.0402840385307812 0.199614633158004 1.4796918767507 0.5 17.4 17 4 abnormal antigen presentation 0.0402840385307812 0.199614633158004 1.4796918767507 0.5 17.4 17 4 increased lactate dehydrogenase level 0.0402840385307812 0.199614633158004 1.4796918767507 0.5 17.4 17 4 amyloid beta deposits 0.0402840385307812 0.199614633158004 1.4796918767507 0.5 17.4 17 4 abnormal pancreas development 0.0402840385307812 0.199614633158004 1.4796918767507 0.5 17.4 17 4 abnormal viscerocranium morphology 0.0402840385307812 0.199614633158004 1.4796918767507 0.5 17.4 17 4 decreased tongue size 0.0402840385307812 0.199614633158004 1.4796918767507 0.5 17.4 17 4 decreased embryo size 1.26225486461775e-31 1.04661965857889e-28 1.4796918767507 0.5 17.4 17 4 muscular ventricular septal defect 3.23643281837663e-05 0.000718805949617131 1.4796918767507 0.5 17.4 17 4 abnormal apoptosis 7.92311291857987e-05 0.001570417799599 1.4796918767507 0.5 17.4 17 4 incomplete somite formation 0.000888021611736335 0.0111282305249075 1.4796918767507 0.5 17.4 17 4 decreased total retina thickness 0.000888021611736335 0.0111282305249075 1.4796918767507 0.5 17.4 17 4 abnormal spongiotrophoblast layer morphology 0.00223445201000062 0.0225028314772329 1.4796918767507 0.5 17.4 17 4 ventricular hypoplasia 0.00570478830849348 0.0456291347825644 1.4796918767507 0.5 17.4 17 4 decreased Peyer's patch number 0.00570478830849348 0.0456291347825644 1.4796918767507 0.5 17.4 17 4 abnormal iron level 0.0206380058158807 0.11991390576786 1.4796918767507 0.5 17.4 17 4 abnormal thymus cortex morphology 0.0206380058158807 0.11991390576786 1.4796918767507 0.5 17.4 17 4 abnormal white adipose tissue morphology 0.0206380058158807 0.11991390576786 1.4796918767507 0.5 17.4 17 4 absent allantois 0.0206380058158807 0.11991390576786 1.4796918767507 0.5 17.4 17 4 abnormal neutrophil morphology 0.0206380058158807 0.11991390576786 1.4796918767507 0.5 17.4 17 4 jerky movement 0.0206380058158807 0.11991390576786 1.4796918767507 0.5 17.4 17 4 abnormal macrophage chemotaxis 0.0206380058158807 0.11991390576786 1.4796918767507 0.5 17.4 17 4 primary atelectasis 0.0206380058158807 0.11991390576786 1.4796918767507 0.5 17.4 17 4 abnormal bone marrow cell number 0.0287484376253315 0.154787312971888 1.4796918767507 0.5 17.4 17 4 disorganized retinal layers 0.0287484376253315 0.154787312971888 1.4796918767507 0.5 17.4 17 4 abnormal meiosis 0.0287484376253315 0.154787312971888 1.4796918767507 0.5 17.4 17 4 kidney degeneration 0.0287484376253315 0.154787312971888 1.4796918767507 0.5 17.4 17 4 impaired embryo implantation 0.0568790382985603 0.255390988750305 1.4796918767507 0.5 17.4 17 4 myocarditis 0.0568790382985603 0.255390988750305 1.4796918767507 0.5 17.4 17 4 increased growth rate 0.0568790382985603 0.255390988750305 1.4796918767507 0.5 17.4 17 4 abnormal AMPA-mediated synaptic currents 0.0568790382985603 0.255390988750305 1.4796918767507 0.5 17.4 17 4 abnormal gastrocnemius morphology 0.0568790382985603 0.255390988750305 1.4796918767507 0.5 17.4 17 4 absent tail 0.0568790382985603 0.255390988750305 1.4796918767507 0.5 17.4 17 4 delayed somite formation 0.0568790382985603 0.255390988750305 1.4796918767507 0.5 17.4 17 4 abnormal rostral-caudal body axis extension 0.0568790382985603 0.255390988750305 1.4796918767507 0.5 17.4 17 4 small parietal bone 0.0568790382985603 0.255390988750305 1.4796918767507 0.5 17.4 17 4 abnormal cochlear outer hair cell physiology 0.0568790382985603 0.255390988750305 1.4796918767507 0.5 17.4 17 4 prenatal growth retardation 0.0568790382985603 0.255390988750305 1.4796918767507 0.5 17.4 17 4 abnormal colon goblet cell morphology 0.0568790382985603 0.255390988750305 1.4796918767507 0.5 17.4 17 4 increased T cell number 5.18471594496463e-07 1.80377355427965e-05 1.4796918767507 0.5 17.4 17 4 abnormal allantois morphology 0.000263572576112152 0.0042163137175497 1.4796918767507 0.5 17.4 17 4 atrial septal defect 0.000263572576112152 0.0042163137175497 1.4796918767507 0.5 17.4 17 4 osteoporosis 0.000356604158046171 0.00547139206229822 1.4796918767507 0.5 17.4 17 4 abnormal long bone epiphysis morphology 0.0107793722645295 0.0756380493879186 1.4796918767507 0.5 17.4 17 4 intestinal inflammation 0.0107793722645295 0.0756380493879186 1.4796918767507 0.5 17.4 17 4 pulmonary vascular congestion 0.0107793722645295 0.0756380493879186 1.4796918767507 0.5 17.4 17 4 spleen atrophy 0.0148862159738058 0.0973179033767199 1.4796918767507 0.5 17.4 17 4 dilated vasculature 0.0148862159738058 0.0973179033767199 1.4796918767507 0.5 17.4 17 4 abnormal induced retinal neovascularization 0.0148862159738058 0.0973179033767199 1.4796918767507 0.5 17.4 17 4 abnormal neuron proliferation 0.0148862159738058 0.0973179033767199 1.4796918767507 0.5 17.4 17 4 retarded hair growth 0.0811277160179789 0.308907955015373 1.4796918767507 0.5 17.4 17 4 abnormal prostate gland epithelium morphology 0.0811277160179789 0.308907955015373 1.4796918767507 0.5 17.4 17 4 abnormal immune cell physiology 0.0811277160179789 0.308907955015373 1.4796918767507 0.5 17.4 17 4 increased natural killer cell mediated cytotoxicity 0.0811277160179789 0.308907955015373 1.4796918767507 0.5 17.4 17 4 absent seminal vesicle 0.0811277160179789 0.308907955015373 1.4796918767507 0.5 17.4 17 4 increased atrioventricular cushion size 0.0811277160179789 0.308907955015373 1.4796918767507 0.5 17.4 17 4 abnormal pillar cell morphology 0.0811277160179789 0.308907955015373 1.4796918767507 0.5 17.4 17 4 abnormal plasma membrane morphology 0.0811277160179789 0.308907955015373 1.4796918767507 0.5 17.4 17 4 ascites 0.0811277160179789 0.308907955015373 1.4796918767507 0.5 17.4 17 4 protruding tongue 0.0811277160179789 0.308907955015373 1.4796918767507 0.5 17.4 17 4 abnormal hippocampus neuron morphology 0.0811277160179789 0.308907955015373 1.4796918767507 0.5 17.4 17 4 abnormal left subclavian artery morphology 0.0811277160179789 0.308907955015373 1.4796918767507 0.5 17.4 17 4 thick aortic valve cusps 0.0811277160179789 0.308907955015373 1.4796918767507 0.5 17.4 17 4 decreased macrophage apoptosis 0.0811277160179789 0.308907955015373 1.4796918767507 0.5 17.4 17 4 decreased circulating lactate level 0.0811277160179789 0.308907955015373 1.4796918767507 0.5 17.4 17 4 decreased circulating serum albumin level 1.79210882180652e-07 7.07598522895827e-06 1.46474549415726 0.494949494949495 17.4 17 4 lethality throughout fetal growth and development, complete penetrance 5.57763976265043e-13 6.76798971199656e-11 1.4641161727849 0.494736842105263 17.4 17 4 abnormal muscle physiology 7.75347867785287e-07 2.55454016041841e-05 1.46306612532654 0.49438202247191 17.4 17 4 abnormal placenta morphology 3.37119708380862e-06 9.86570911291052e-05 1.46096159982981 0.493670886075949 17.4 17 4 seminiferous tubule degeneration 8.16696733122872e-06 0.000216120545068419 1.45942212501439 0.493150684931507 17.4 17 4 preweaning lethality, complete penetrance 1.61681061273008e-45 8.04363279833216e-42 1.45569687334393 0.491891891891892 17.4 17 4 abnormal platelet physiology 0.000118352219362808 0.00220525202745307 1.45278838808251 0.490909090909091 17.4 17 4 decreased circulating total protein level 0.000118352219362808 0.00220525202745307 1.45278838808251 0.490909090909091 17.4 17 4 abnormal dendritic spine morphology 0.000215524266397853 0.00368465025886363 1.4506783105399 0.490196078431373 17.4 17 4 enlarged liver 2.65471618712338e-07 9.85612912756627e-06 1.45009803921569 0.49 17.4 17 4 trabecula carnea hypoplasia 0.000532305413131186 0.00739988442697946 1.44680983504513 0.488888888888889 17.4 17 4 abnormal homeostasis 0.000720669821735848 0.00948500625168213 1.4452804377565 0.488372093023256 17.4 17 4 abnormal double-strand DNA break repair 0.000720669821735848 0.00948500625168213 1.4452804377565 0.488372093023256 17.4 17 4 decreased inflammatory response 2.76639813002656e-06 8.29086186559165e-05 1.44446111778045 0.488095238095238 17.4 17 4 abnormal leukocyte adhesion 0.00132470342816473 0.0153622367252204 1.44175105939812 0.487179487179487 17.4 17 4 failure of heart looping 0.00132470342816473 0.0153622367252204 1.44175105939812 0.487179487179487 17.4 17 4 abnormal response to injury 0.00132470342816473 0.0153622367252204 1.44175105939812 0.487179487179487 17.4 17 4 malocclusion 0.00179891111813786 0.0186062012738792 1.43970020440609 0.486486486486487 17.4 17 4 abnormal vocalization 0.00179891111813786 0.0186062012738792 1.43970020440609 0.486486486486487 17.4 17 4 impaired skeletal muscle contractility 0.00179891111813786 0.0186062012738792 1.43970020440609 0.486486486486487 17.4 17 4 skin inflammation 0.00179891111813786 0.0186062012738792 1.43970020440609 0.486486486486487 17.4 17 4 decreased triglyceride level 0.00244587615383031 0.0240004612727925 1.43741496598639 0.485714285714286 17.4 17 4 lung inflammation 4.05113831623717e-09 2.21844127407858e-07 1.4361715274345 0.485294117647059 17.4 17 4 decreased circulating alanine transaminase level 2.92395109432571e-05 0.000661211667921381 1.4361715274345 0.485294117647059 17.4 17 4 abnormal vascular development 3.93156113696349e-05 0.000839464234179973 1.43485272897038 0.484848484848485 17.4 17 4 enlarged pericardium 0.00333007279305477 0.0307938887461849 1.43485272897038 0.484848484848485 17.4 17 4 abnormal ovarian folliculogenesis 0.00333007279305477 0.0307938887461849 1.43485272897038 0.484848484848485 17.4 17 4 increased sacral vertebrae number 5.28833031772333e-05 0.00110543879540645 1.43345150560224 0.484375 17.4 17 4 abnormal immune system physiology 2.31110980777017e-08 1.11628847511229e-06 1.43195988072648 0.483870967741935 17.4 17 4 autoimmune response 0.00454086954203476 0.0378405795169563 1.43195988072648 0.483870967741935 17.4 17 4 abnormal CD8-positive, alpha beta T cell morphology 0.00454086954203476 0.0378405795169563 1.43195988072648 0.483870967741935 17.4 17 4 absent mesoderm 9.57952820979577e-05 0.00186894717034251 1.43036881419234 0.483333333333333 17.4 17 4 abnormal parietal bone morphology 0.00620262194053956 0.0484427694728168 1.42866801893171 0.482758620689655 17.4 17 4 abnormal microglial cell morphology 0.00620262194053956 0.0484427694728168 1.42866801893171 0.482758620689655 17.4 17 4 decreased trophoblast giant cell number 0.00620262194053956 0.0484427694728168 1.42866801893171 0.482758620689655 17.4 17 4 increased double-positive T cell number 0.00620262194053956 0.0484427694728168 1.42866801893171 0.482758620689655 17.4 17 4 blood in lymph vessels 0.00620262194053956 0.0484427694728168 1.42866801893171 0.482758620689655 17.4 17 4 reduced fertility 4.41200775813961e-09 2.38584115182006e-07 1.42646555024888 0.482014388489209 17.4 17 4 increased circulating alkaline phosphatase level 2.6559995531334e-10 1.76181303691182e-08 1.42488847390808 0.481481481481481 17.4 17 4 decreased platelet aggregation 0.00023435069419345 0.00392557139263439 1.42488847390808 0.481481481481481 17.4 17 4 abnormal heart valve morphology 0.00848915712313916 0.0627541704125072 1.42488847390808 0.481481481481481 17.4 17 4 abnormal brain commissure morphology 0.00848915712313916 0.0627541704125072 1.42488847390808 0.481481481481481 17.4 17 4 abnormal eye muscle morphology 0.00848915712313916 0.0627541704125072 1.42488847390808 0.481481481481481 17.4 17 4 abnormal nervous system morphology 9.75524565440477e-06 0.000251462938500848 1.42350104598802 0.481012658227848 17.4 17 4 distended pericardium 0.000316102823813089 0.0049132306611329 1.42278065072183 0.480769230769231 17.4 17 4 lethality throughout fetal growth and development, incomplete penetrance 3.81761898128728e-11 3.05321120927682e-09 1.42182683129118 0.480446927374302 17.4 17 4 decreased circulating alkaline phosphatase level 0.000426625811878252 0.00615206786694001 1.42050420168067 0.48 17.4 17 4 mandible hypoplasia 0.0116447650998771 0.08057400051723 1.42050420168067 0.48 17.4 17 4 abnormal keratinocyte physiology 0.0116447650998771 0.08057400051723 1.42050420168067 0.48 17.4 17 4 increased cellular sensitivity to ionizing radiation 0.0116447650998771 0.08057400051723 1.42050420168067 0.48 17.4 17 4 decreased acute inflammation 0.0116447650998771 0.08057400051723 1.42050420168067 0.48 17.4 17 4 decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 0.0116447650998771 0.08057400051723 1.42050420168067 0.48 17.4 17 4 decreased total body fat amount 2.74129070547489e-19 9.74137232838399e-17 1.41766886395277 0.479041916167665 17.4 17 4 abnormal behavior 3.15195304928788e-16 6.53373600841967e-14 1.41582028494851 0.47841726618705 17.4 17 4 microcephaly 4.25181645480522e-05 0.000900118589900253 1.41535744732676 0.478260869565217 17.4 17 4 abnormal nasal cavity morphology 0.0160149826917498 0.0986927394299759 1.41535744732676 0.478260869565217 17.4 17 4 decreased epididymis weight 0.0160149826917498 0.0986927394299759 1.41535744732676 0.478260869565217 17.4 17 4 abnormal embryo development 1.13741907524182e-08 5.89443739513337e-07 1.4144113527764 0.477941176470588 17.4 17 4 internal hemorrhage 5.71218285186152e-05 0.00118408790366713 1.41343701659768 0.477611940298507 17.4 17 4 abnormal muscle morphology 0.00142539902204074 0.0155873729542299 1.40923035881019 0.476190476190476 17.4 17 4 abnormal eye pigmentation 0.0220924019467166 0.127063236629959 1.40923035881019 0.476190476190476 17.4 17 4 increased acute inflammation 0.0220924019467166 0.127063236629959 1.40923035881019 0.476190476190476 17.4 17 4 gliosis 0.000103199290599937 0.00198998632067708 1.40923035881019 0.476190476190476 17.4 17 4 increased circulating aspartate transaminase level 0.000103199290599937 0.00198998632067708 1.40923035881019 0.476190476190476 17.4 17 4 increased circulating alanine transaminase level 1.8867601638992e-05 0.000449121139492753 1.40381024204554 0.474358974358974 17.4 17 4 increased bone marrow cell number 0.00261871167389922 0.0253958880655919 1.40181335692172 0.473684210526316 17.4 17 4 decreased neuron apoptosis 0.00261871167389922 0.0253958880655919 1.40181335692172 0.473684210526316 17.4 17 4 altered susceptibility to infection 0.0305860864112473 0.163268004180209 1.40181335692172 0.473684210526316 17.4 17 4 delayed sexual maturation 0.0305860864112473 0.163268004180209 1.40181335692172 0.473684210526316 17.4 17 4 abnormal digestive system development 0.0305860864112473 0.163268004180209 1.40181335692172 0.473684210526316 17.4 17 4 abnormal optic vesicle formation 0.0305860864112473 0.163268004180209 1.40181335692172 0.473684210526316 17.4 17 4 abnormal contextual conditioning behavior 0.000338349326800229 0.00521141764963201 1.39898141074612 0.472727272727273 17.4 17 4 small spleen 4.6772463344136e-06 0.00013072640738038 1.39839012528088 0.472527472527473 17.4 17 4 increased grip strength 4.6772463344136e-06 0.00013072640738038 1.39839012528088 0.472527472527473 17.4 17 4 abnormal lysosome morphology 0.00355502508192813 0.0326917740898197 1.39748677248677 0.472222222222222 17.4 17 4 embryonic growth arrest 5.91989251389226e-13 6.84917796665441e-11 1.39569190121463 0.471615720524017 17.4 17 4 edema 4.73520072967195e-10 2.96097044720385e-08 1.39366327926519 0.47093023255814 17.4 17 4 increased lung adenocarcinoma incidence 0.000614271630083052 0.00823720043035898 1.39265117811831 0.470588235294118 17.4 17 4 abnormal response to novel object 0.000614271630083052 0.00823720043035898 1.39265117811831 0.470588235294118 17.4 17 4 abnormal brown adipose tissue morphology 0.00483185441275667 0.0397401040892883 1.39265117811831 0.470588235294118 17.4 17 4 abnormal interatrial septum morphology 0.0425292065341115 0.208661540934127 1.39265117811831 0.470588235294118 17.4 17 4 aminoaciduria 0.0425292065341115 0.208661540934127 1.39265117811831 0.470588235294118 17.4 17 4 abnormal ectoplacental cone morphology 0.0425292065341115 0.208661540934127 1.39265117811831 0.470588235294118 17.4 17 4 decreased neutrophil cell number 2.92485867467747e-07 1.06212933624236e-05 1.39116330292801 0.47008547008547 17.4 17 4 abnormal long bone hypertrophic chondrocyte zone 0.000828312154858881 0.0105662896677511 1.38909849654147 0.469387755102041 17.4 17 4 decreased circulating LDL cholesterol level 0.000147595750090559 0.00264132682266378 1.38721113445378 0.46875 17.4 17 4 abnormal vertebral body morphology 0.00657594383500604 0.0511696146317121 1.38721113445378 0.46875 17.4 17 4 hepatic necrosis 0.00111756737216983 0.0133973437989034 1.38524345908576 0.468085106382979 17.4 17 4 increased bone mineral content 9.28140752840424e-07 3.01797401658896e-05 1.38466579292267 0.467889908256881 17.4 17 4 pericardial effusion 0.000198211511843653 0.00342396622021588 1.38422788470227 0.467741935483871 17.4 17 4 embryonic lethality, complete penetrance 7.71384293539371e-17 1.6685377653732e-14 1.38228269364172 0.467084639498433 17.4 17 4 increased susceptibility to parasitic infection 8.88163692466118e-06 0.000231341066493138 1.38104575163399 0.466666666666667 17.4 17 4 epidermal hyperplasia 0.000266262489096022 0.00424569193350227 1.38104575163399 0.466666666666667 17.4 17 4 abnormal myocardial trabeculae morphology 0.00150875326655976 0.0163174945676843 1.38104575163399 0.466666666666667 17.4 17 4 abnormal metabolism 0.00150875326655976 0.0163174945676843 1.38104575163399 0.466666666666667 17.4 17 4 abnormal microglial cell physiology 0.00896276286942921 0.0659611616500152 1.38104575163399 0.466666666666667 17.4 17 4 abnormal optic cup morphology 0.00896276286942921 0.0659611616500152 1.38104575163399 0.466666666666667 17.4 17 4 hyperpigmentation 0.0594509315617163 0.258826972679877 1.38104575163399 0.466666666666667 17.4 17 4 abnormal epidermis stratum spinosum morphology 0.0594509315617163 0.258826972679877 1.38104575163399 0.466666666666667 17.4 17 4 audiogenic seizures 0.0594509315617163 0.258826972679877 1.38104575163399 0.466666666666667 17.4 17 4 abnormal apical ectodermal ridge morphology 0.0594509315617163 0.258826972679877 1.38104575163399 0.466666666666667 17.4 17 4 decreased aggression towards males 0.0594509315617163 0.258826972679877 1.38104575163399 0.466666666666667 17.4 17 4 abnormal trophectoderm morphology 0.0594509315617163 0.258826972679877 1.38104575163399 0.466666666666667 17.4 17 4 bicuspid aortic valve 0.0594509315617163 0.258826972679877 1.38104575163399 0.466666666666667 17.4 17 4 abnormal coronary vessel morphology 0.0594509315617163 0.258826972679877 1.38104575163399 0.466666666666667 17.4 17 4 abnormal seminiferous tubule morphology 1.96625546047201e-08 9.59031462338062e-07 1.37834311806915 0.465753424657534 17.4 17 4 astrocytosis 6.46075582895834e-05 0.00131730574791261 1.37834311806915 0.465753424657534 17.4 17 4 abnormal left-right axis patterning 0.00203820702230587 0.0208215193757119 1.37645755976809 0.465116279069767 17.4 17 4 decreased circulating cholesterol level 4.24095450583722e-10 2.70496777776156e-08 1.37457715326568 0.46448087431694 17.4 17 4 small superior cervical ganglion 0.0122361156770333 0.083849415279946 1.37399959983994 0.464285714285714 17.4 17 4 straub tail 0.0122361156770333 0.083849415279946 1.37399959983994 0.464285714285714 17.4 17 4 abnormal mitotic spindle morphology 0.0122361156770333 0.083849415279946 1.37399959983994 0.464285714285714 17.4 17 4 hemopericardium 0.00275541449389936 0.0264636816740334 1.37142173942748 0.463414634146341 17.4 17 4 lethality at weaning, incomplete penetrance 0.00275541449389936 0.0264636816740334 1.37142173942748 0.463414634146341 17.4 17 4 ventricular septal defect 8.2262983237864e-08 3.43914572780146e-06 1.37089100346021 0.463235294117647 17.4 17 4 abnormal snout morphology 0.000869844892600166 0.0109556413688249 1.36586942469295 0.461538461538462 17.4 17 4 abnormal placenta vasculature 0.000869844892600166 0.0109556413688249 1.36586942469295 0.461538461538462 17.4 17 4 abnormal nasal bone morphology 0.0167361737782059 0.101292535944737 1.36586942469295 0.461538461538462 17.4 17 4 abnormal Schwann cell morphology 0.0167361737782059 0.101292535944737 1.36586942469295 0.461538461538462 17.4 17 4 decreased circulating glycerol level 0.0167361737782059 0.101292535944737 1.36586942469295 0.461538461538462 17.4 17 4 absent teeth 0.0836617101481607 0.313180592917306 1.36586942469295 0.461538461538462 17.4 17 4 increased foot pad pigmentation 0.0836617101481607 0.313180592917306 1.36586942469295 0.461538461538462 17.4 17 4 abnormal telomere length 0.0836617101481607 0.313180592917306 1.36586942469295 0.461538461538462 17.4 17 4 axonal dystrophy 0.0836617101481607 0.313180592917306 1.36586942469295 0.461538461538462 17.4 17 4 muscle fatigue 0.0836617101481607 0.313180592917306 1.36586942469295 0.461538461538462 17.4 17 4 small interparietal bone 0.0836617101481607 0.313180592917306 1.36586942469295 0.461538461538462 17.4 17 4 small pituitary gland 0.0836617101481607 0.313180592917306 1.36586942469295 0.461538461538462 17.4 17 4 increased insulin sensitivity 4.88277424547858e-08 2.18845061903207e-06 1.36586942469295 0.461538461538462 17.4 17 4 anophthalmia 1.66667857352084e-05 0.00039864066842626 1.36331161678154 0.460674157303371 17.4 17 4 testicular atrophy 0.00117048940999053 0.0139644719777048 1.36131652661064 0.46 17.4 17 4 abnormal circulating protein level 0.00117048940999053 0.0139644719777048 1.36131652661064 0.46 17.4 17 4 abnormal branching of the mammary ductal tree 0.00504772195114987 0.0409664220342098 1.35971685971686 0.459459459459459 17.4 17 4 hydrops fetalis 0.00012129224307191 0.00225160040777146 1.35638422035481 0.458333333333333 17.4 17 4 abnormal intestinal epithelium morphology 0.00157568142649516 0.0170043711427623 1.35638422035481 0.458333333333333 17.4 17 4 abnormal neural tube closure 3.96476017740496e-05 0.000842935123187593 1.3548985859404 0.457831325301205 17.4 17 4 preweaning lethality, incomplete penetrance 1.67170177392071e-19 6.39747409635043e-17 1.35306787751776 0.45721271393643 17.4 17 4 ovary cysts 0.00684109926237884 0.0527666183416042 1.35286114445778 0.457142857142857 17.4 17 4 abnormal intestinal goblet cell morphology 0.00684109926237884 0.0527666183416042 1.35286114445778 0.457142857142857 17.4 17 4 abnormal midbrain development 0.00684109926237884 0.0527666183416042 1.35286114445778 0.457142857142857 17.4 17 4 abnormal hippocampus pyramidal cell morphology 0.00684109926237884 0.0527666183416042 1.35286114445778 0.457142857142857 17.4 17 4 delayed wound healing 0.00212204517893509 0.021589314448266 1.35102301790281 0.456521739130435 17.4 17 4 oxidative stress 2.3180889841993e-05 0.000543985504546769 1.34816370992842 0.455555555555556 17.4 17 4 decreased bone mineral density 5.89563452247778e-13 6.84917796665441e-11 1.34618584275816 0.454887218045113 17.4 17 4 insulin resistance 3.73855953140168e-07 1.33808155890096e-05 1.34517443340973 0.454545454545455 17.4 17 4 muscular atrophy 0.00285914820620542 0.0273543506266769 1.34517443340973 0.454545454545455 17.4 17 4 decreased macrophage cell number 0.00285914820620542 0.0273543506266769 1.34517443340973 0.454545454545455 17.4 17 4 increased cardiomyocyte apoptosis 0.00928083636996541 0.0681005323607344 1.34517443340973 0.454545454545455 17.4 17 4 increased osteoblast cell number 0.00928083636996541 0.0681005323607344 1.34517443340973 0.454545454545455 17.4 17 4 increased coping response 0.0315199266818725 0.166132676518053 1.34517443340973 0.454545454545455 17.4 17 4 aphakia 0.0315199266818725 0.166132676518053 1.34517443340973 0.454545454545455 17.4 17 4 abnormal lysosome physiology 0.0315199266818725 0.166132676518053 1.34517443340973 0.454545454545455 17.4 17 4 parakeratosis 0.0315199266818725 0.166132676518053 1.34517443340973 0.454545454545455 17.4 17 4 cleft upper lip 0.0315199266818725 0.166132676518053 1.34517443340973 0.454545454545455 17.4 17 4 increased bone volume 0.0315199266818725 0.166132676518053 1.34517443340973 0.454545454545455 17.4 17 4 decreased atrioventricular cushion size 0.118751608020479 0.394385347064008 1.34517443340973 0.454545454545455 17.4 17 4 abnormal large intestine morphology 0.118751608020479 0.394385347064008 1.34517443340973 0.454545454545455 17.4 17 4 delayed hepatic development 0.118751608020479 0.394385347064008 1.34517443340973 0.454545454545455 17.4 17 4 impaired myelopoiesis 0.118751608020479 0.394385347064008 1.34517443340973 0.454545454545455 17.4 17 4 abnormal larynx morphology 0.118751608020479 0.394385347064008 1.34517443340973 0.454545454545455 17.4 17 4 abnormal vestibular ganglion morphology 0.118751608020479 0.394385347064008 1.34517443340973 0.454545454545455 17.4 17 4 decreased post-tetanic potentiation 0.118751608020479 0.394385347064008 1.34517443340973 0.454545454545455 17.4 17 4 fused joints 0.118751608020479 0.394385347064008 1.34517443340973 0.454545454545455 17.4 17 4 rectal hemorrhage 0.118751608020479 0.394385347064008 1.34517443340973 0.454545454545455 17.4 17 4 dilated renal glomerular capsule 0.118751608020479 0.394385347064008 1.34517443340973 0.454545454545455 17.4 17 4 abnormal coronal suture morphology 0.118751608020479 0.394385347064008 1.34517443340973 0.454545454545455 17.4 17 4 abnormal spinal cord ventral horn morphology 0.118751608020479 0.394385347064008 1.34517443340973 0.454545454545455 17.4 17 4 increased glycogen level 0.118751608020479 0.394385347064008 1.34517443340973 0.454545454545455 17.4 17 4 abnormal platelet aggregation 0.118751608020479 0.394385347064008 1.34517443340973 0.454545454545455 17.4 17 4 aberrant origin of the right subclavian artery 0.118751608020479 0.394385347064008 1.34517443340973 0.454545454545455 17.4 17 4 common atrioventricular valve 0.118751608020479 0.394385347064008 1.34517443340973 0.454545454545455 17.4 17 4 decreased embryonic cilium length 0.118751608020479 0.394385347064008 1.34517443340973 0.454545454545455 17.4 17 4 chylous ascites 0.118751608020479 0.394385347064008 1.34517443340973 0.454545454545455 17.4 17 4 thin hypoglossal nerve 0.118751608020479 0.394385347064008 1.34517443340973 0.454545454545455 17.4 17 4 reduced sympathetic cervical ganglion size 0.118751608020479 0.394385347064008 1.34517443340973 0.454545454545455 17.4 17 4 kyphosis 7.36569095104733e-08 3.13199251978295e-06 1.3415873015873 0.453333333333333 17.4 17 4 prenatal lethality, complete penetrance 2.73559017440635e-13 3.58146345201884e-11 1.34130342784596 0.453237410071942 17.4 17 4 increased heart weight 2.20123195087755e-07 8.48924725241538e-06 1.34130342784596 0.453237410071942 17.4 17 4 abnormal placenta development 0.00121251862865083 0.0143968500657229 1.34009830347233 0.452830188679245 17.4 17 4 increased circulating bilirubin level 0.00121251862865083 0.0143968500657229 1.34009830347233 0.452830188679245 17.4 17 4 disheveled coat 0.00385412292717388 0.0344860819472843 1.33876884086968 0.452380952380952 17.4 17 4 skin edema 0.00385412292717388 0.0344860819472843 1.33876884086968 0.452380952380952 17.4 17 4 spina bifida 0.00385412292717388 0.0344860819472843 1.33876884086968 0.452380952380952 17.4 17 4 impaired glucose tolerance 7.39221903938044e-12 6.96820566508071e-10 1.33649588867805 0.451612903225806 17.4 17 4 prenatal lethality 0.000519543001156526 0.00726046750211718 1.33649588867805 0.451612903225806 17.4 17 4 osteopetrosis 0.0126043220802246 0.0856390489124474 1.33649588867805 0.451612903225806 17.4 17 4 decreased thymus weight 0.0126043220802246 0.0856390489124474 1.33649588867805 0.451612903225806 17.4 17 4 pale kidney 0.0126043220802246 0.0856390489124474 1.33649588867805 0.451612903225806 17.4 17 4 abnormal mitochondrial ATP synthesis coupled electron transport 0.0126043220802246 0.0856390489124474 1.33649588867805 0.451612903225806 17.4 17 4 increased bone mineral density 3.49314220403483e-06 0.000101627967632008 1.33565107458913 0.451327433628319 17.4 17 4 abnormal spermatogenesis 3.82241253773619e-09 2.13668566013905e-07 1.33493941054683 0.451086956521739 17.4 17 4 hemorrhage 2.90175663847724e-11 2.40603987940404e-09 1.33487096966446 0.451063829787234 17.4 17 4 abnormal cued conditioning behavior 0.00162738258634309 0.0174487680324502 1.33462404569671 0.450980392156863 17.4 17 4 failure of chorioallantoic fusion 0.00162738258634309 0.0174487680324502 1.33462404569671 0.450980392156863 17.4 17 4 abnormal liver physiology 1.40097921087148e-05 0.000346759779805256 1.33172268907563 0.45 17.4 17 4 abnormal female reproductive system morphology 0.00519795727075493 0.0419122162431212 1.33172268907563 0.45 17.4 17 4 abnormal circulating enzyme level 0.0434314349509721 0.211081897660661 1.33172268907563 0.45 17.4 17 4 increased circulating LDL cholesterol level 0.00218464898116177 0.022045899962028 1.32870290973532 0.448979591836735 17.4 17 4 decreased circulating creatinine level 0.00218464898116177 0.022045899962028 1.32870290973532 0.448979591836735 17.4 17 4 increased urine protein level 0.000129804505570928 0.00236548503741893 1.32792860734037 0.448717948717949 17.4 17 4 increased embryonic tissue cell apoptosis 0.000129804505570928 0.00236548503741893 1.32792860734037 0.448717948717949 17.4 17 4 increased circulating triglyceride level 2.34956449628482e-07 8.92296440382977e-06 1.32662030329373 0.448275862068966 17.4 17 4 glomerulosclerosis 0.000930063391389718 0.0115676634304096 1.32662030329373 0.448275862068966 17.4 17 4 embryonic lethality during organogenesis, incomplete penetrance 9.16351176948716e-11 6.70418691958803e-09 1.32528924613324 0.447826086956522 17.4 17 4 decreased white adipose tissue amount 0.000399637417974869 0.00598854263381017 1.32509720306033 0.447761194029851 17.4 17 4 decreased hair follicle number 0.00701406360416229 0.0536020989719007 1.32393483709273 0.447368421052632 17.4 17 4 abnormal craniofacial morphology 1.44094331179966e-05 0.000353137585034647 1.32166653068995 0.446601941747573 17.4 17 4 abnormal angiogenesis 0.000230327596427408 0.00388433827873341 1.31972518737225 0.445945945945946 17.4 17 4 abnormal heart morphology 1.2448722316737e-10 8.84748478939525e-09 1.31955206324954 0.445887445887446 17.4 17 4 decreased circulating HDL cholesterol level 1.63247861535052e-06 5.04446031762041e-05 1.31785057773109 0.4453125 17.4 17 4 decreased heart weight 0.000133030745618512 0.00241543050894926 1.31528166822284 0.444444444444444 17.4 17 4 increased susceptibility to bacterial infection induced morbidity/mortality 0.000306751967548522 0.00486006079871954 1.31528166822284 0.444444444444444 17.4 17 4 diluted coat color 0.00166519848141241 0.0178158332151113 1.31528166822284 0.444444444444444 17.4 17 4 abnormal ovarian follicle morphology 0.00393946415792194 0.0350605262713088 1.31528166822284 0.444444444444444 17.4 17 4 impaired wound healing 0.00946995860673944 0.0684121952473409 1.31528166822284 0.444444444444444 17.4 17 4 abnormal pharyngeal arch morphology 0.00946995860673944 0.0684121952473409 1.31528166822284 0.444444444444444 17.4 17 4 abnormal retinal blood vessel morphology 0.00946995860673944 0.0684121952473409 1.31528166822284 0.444444444444444 17.4 17 4 rectal prolapse 0.0233337871022592 0.133125677561628 1.31528166822284 0.444444444444444 17.4 17 4 abnormal skin appearance 0.0233337871022592 0.133125677561628 1.31528166822284 0.444444444444444 17.4 17 4 cortical renal glomerulopathies 0.0600421671086962 0.258826972679877 1.31528166822284 0.444444444444444 17.4 17 4 delayed kidney development 0.0600421671086962 0.258826972679877 1.31528166822284 0.444444444444444 17.4 17 4 abnormal phrenic nerve morphology 0.0600421671086962 0.258826972679877 1.31528166822284 0.444444444444444 17.4 17 4 long tibia 0.0600421671086962 0.258826972679877 1.31528166822284 0.444444444444444 17.4 17 4 decreased pulmonary respiratory rate 0.0600421671086962 0.258826972679877 1.31528166822284 0.444444444444444 17.4 17 4 abnormal pregnancy 0.0600421671086962 0.258826972679877 1.31528166822284 0.444444444444444 17.4 17 4 increased adipocyte glucose uptake 0.0600421671086962 0.258826972679877 1.31528166822284 0.444444444444444 17.4 17 4 abnormal heart development 1.45028309620677e-07 5.81867613195859e-06 1.31111938446265 0.443037974683544 17.4 17 4 abnormal embryo size 8.59111534699185e-06 0.000224951572901497 1.30946183783248 0.442477876106195 17.4 17 4 abnormal embryonic tissue morphology 4.32182327139465e-07 1.53579076965631e-05 1.30857104746661 0.442176870748299 17.4 17 4 kidney failure 0.0052917230185277 0.0425304071359859 1.30763468177969 0.441860465116279 17.4 17 4 abnormal hepatocyte morphology 1.13714695419527e-05 0.00028717289833104 1.30639462992404 0.441441441441441 17.4 17 4 abnormal liver morphology 2.92101817354659e-08 1.38400622984707e-06 1.30609674037213 0.441340782122905 17.4 17 4 decreased regulatory T cell number 0.0127931905467092 0.0865933645848681 1.30561047948591 0.441176470588235 17.4 17 4 abnormal skin physiology 0.0127931905467092 0.0865933645848681 1.30561047948591 0.441176470588235 17.4 17 4 decreased exploration in new environment 0.000135606822560192 0.00245325069904347 1.30353808189943 0.44047619047619 17.4 17 4 short stride length 0.00298148864422489 0.0281459316983279 1.30212885154062 0.44 17.4 17 4 spontaneous skin ulceration 0.0318146450562482 0.166258255414742 1.30212885154062 0.44 17.4 17 4 abnormal primitive streak morphology 0.0318146450562482 0.166258255414742 1.30212885154062 0.44 17.4 17 4 abnormal egg cylinder morphology 0.0318146450562482 0.166258255414742 1.30212885154062 0.44 17.4 17 4 abnormal preimplantation embryo development 0.0318146450562482 0.166258255414742 1.30212885154062 0.44 17.4 17 4 delayed bone ossification 0.000312378611862086 0.00490091162848098 1.30212885154062 0.44 17.4 17 4 reduced female fertility 4.02775218088397e-10 2.6023463766101e-08 1.30110837438424 0.439655172413793 17.4 17 4 palatal shelves fail to meet at midline 0.00710951248742452 0.0539057471662609 1.29924164787866 0.439024390243902 17.4 17 4 incomplete embryo turning 0.00169051805383722 0.0179313895950765 1.29797533048307 0.43859649122807 17.4 17 4 decreased brain weight 0.00169051805383722 0.0179313895950765 1.29797533048307 0.43859649122807 17.4 17 4 abnormal lipid homeostasis 2.97103607942075e-06 8.81129865319009e-05 1.29757595345831 0.438461538461538 17.4 17 4 decreased hematocrit 7.67016487504207e-07 2.54393801688895e-05 1.2972641111239 0.438356164383562 17.4 17 4 perinatal lethality, incomplete penetrance 9.19242305567664e-10 5.50991622915558e-08 1.29636721945415 0.438053097345133 17.4 17 4 abnormal lymph node morphology 0.00398932187131625 0.0350654591860232 1.29473039215686 0.4375 17.4 17 4 decreased bone mineral content 4.62893073866261e-09 2.47622907794048e-07 1.29473039215686 0.4375 17.4 17 4 scoliosis 0.0172930607153945 0.103654189227817 1.29473039215686 0.4375 17.4 17 4 abnormal heart atrium morphology 0.0172930607153945 0.103654189227817 1.29473039215686 0.4375 17.4 17 4 increased fatty acid level 0.0172930607153945 0.103654189227817 1.29473039215686 0.4375 17.4 17 4 pancreatic islet hyperplasia 0.0172930607153945 0.103654189227817 1.29473039215686 0.4375 17.4 17 4 mixed cellular infiltration to dermis 0.083330649067793 0.313180592917306 1.29473039215686 0.4375 17.4 17 4 poor circulation 0.083330649067793 0.313180592917306 1.29473039215686 0.4375 17.4 17 4 white spotting 0.083330649067793 0.313180592917306 1.29473039215686 0.4375 17.4 17 4 small pancreas 0.083330649067793 0.313180592917306 1.29473039215686 0.4375 17.4 17 4 abnormal Langerhans cell physiology 0.083330649067793 0.313180592917306 1.29473039215686 0.4375 17.4 17 4 decreased circulating triiodothyronine level 0.083330649067793 0.313180592917306 1.29473039215686 0.4375 17.4 17 4 decreased creatinine clearance 0.083330649067793 0.313180592917306 1.29473039215686 0.4375 17.4 17 4 abnormal pulmonary alveolus wall morphology 0.083330649067793 0.313180592917306 1.29473039215686 0.4375 17.4 17 4 embryonic lethality between somite formation and embryo turning, incomplete penetrance 0.083330649067793 0.313180592917306 1.29473039215686 0.4375 17.4 17 4 abnormal skeletal muscle fiber morphology 0.00055118331266584 0.00759594731443921 1.29212530082456 0.436619718309859 17.4 17 4 abnormal head morphology 0.00225482178241733 0.0225709021479401 1.29136745607334 0.436363636363636 17.4 17 4 abnormal joint morphology 0.00225482178241733 0.0225709021479401 1.29136745607334 0.436363636363636 17.4 17 4 increased rib number 0.000316416278259284 0.0049132306611329 1.28998778998779 0.435897435897436 17.4 17 4 abnormal heart looping 0.00955340151738554 0.0684121952473409 1.28998778998779 0.435897435897436 17.4 17 4 increased hepatocyte apoptosis 0.00955340151738554 0.0684121952473409 1.28998778998779 0.435897435897436 17.4 17 4 abnormal bone structure 2.36635865482303e-08 1.13198406805236e-06 1.28802194452911 0.435233160621762 17.4 17 4 abnormal testis morphology 1.54794663655899e-05 0.000374211707132452 1.28668858847887 0.434782608695652 17.4 17 4 abnormal myelin sheath morphology 0.00533747875714261 0.0428289626077169 1.28668858847887 0.434782608695652 17.4 17 4 abnormal postnatal growth 0.0434468066742747 0.211081897660661 1.28668858847887 0.434782608695652 17.4 17 4 conjunctivitis 0.0434468066742747 0.211081897660661 1.28668858847887 0.434782608695652 17.4 17 4 abnormal cochlear ganglion morphology 0.0434468066742747 0.211081897660661 1.28668858847887 0.434782608695652 17.4 17 4 abnormal corneal stroma morphology 0.0434468066742747 0.211081897660661 1.28668858847887 0.434782608695652 17.4 17 4 increased susceptibility to fungal infection 0.0434468066742747 0.211081897660661 1.28668858847887 0.434782608695652 17.4 17 4 abnormal neuron morphology 6.07697614647793e-05 0.00124929571606313 1.28538890303596 0.434343434343434 17.4 17 4 prenatal lethality, incomplete penetrance 3.47067852699431e-12 3.59721368162431e-10 1.28499557717824 0.434210526315789 17.4 17 4 abnormal mesoderm development 0.00300686845812858 0.0282248501494145 1.28426087416099 0.433962264150943 17.4 17 4 decreased circulating glucose level 2.96479695380198e-11 2.41801063035489e-09 1.28346033754003 0.433691756272401 17.4 17 4 intracranial hemorrhage 0.00170471465639691 0.0179763290065056 1.28239962651727 0.433333333333333 17.4 17 4 increased metastatic potential 0.023390233107968 0.133142345208399 1.28239962651727 0.433333333333333 17.4 17 4 liver hemorrhage 0.023390233107968 0.133142345208399 1.28239962651727 0.433333333333333 17.4 17 4 small seminiferous tubules 0.000555705627409586 0.00763711463083616 1.27973351502763 0.432432432432432 17.4 17 4 increased brown adipose tissue amount 0.0128392817729029 0.0866695072187133 1.27973351502763 0.432432432432432 17.4 17 4 increased white adipose tissue amount 0.0128392817729029 0.0866695072187133 1.27973351502763 0.432432432432432 17.4 17 4 hyperglycemia 0.000183614955151402 0.00318287248041194 1.27791571173924 0.431818181818182 17.4 17 4 teratozoospermia 0.000183614955151402 0.00318287248041194 1.27791571173924 0.431818181818182 17.4 17 4 abnormal circadian rhythm 0.00714047987589264 0.0539057471662609 1.27791571173924 0.431818181818182 17.4 17 4 abnormal amino acid level 0.00714047987589264 0.0539057471662609 1.27791571173924 0.431818181818182 17.4 17 4 decreased sensitivity to induced morbidity/mortality 0.00714047987589264 0.0539057471662609 1.27791571173924 0.431818181818182 17.4 17 4 lethality, incomplete penetrance 0.00714047987589264 0.0539057471662609 1.27791571173924 0.431818181818182 17.4 17 4 decreased birth weight 0.000105942069489004 0.00201939385328656 1.27720772519534 0.431578947368421 17.4 17 4 abnormal gastrulation 0.00400874151572143 0.0350654591860232 1.27659691327511 0.431372549019608 17.4 17 4 abnormal trophoblast layer morphology 0.00400874151572143 0.0350654591860232 1.27659691327511 0.431372549019608 17.4 17 4 abnormal somite development 0.000421860929174725 0.0061391217341699 1.27365883062086 0.430379746835443 17.4 17 4 premature death 1.46654994868632e-30 1.04229799924492e-27 1.27174447014578 0.429732868757259 17.4 17 4 abnormal coat/hair pigmentation 3.56376723007812e-05 0.000777620261826256 1.26830732292917 0.428571428571429 17.4 17 4 enhanced long term potentiation 0.00301258658521198 0.028225269795536 1.26830732292917 0.428571428571429 17.4 17 4 abnormal somite shape 0.0316570406711787 0.166132676518053 1.26830732292917 0.428571428571429 17.4 17 4 abnormal retinal inner nuclear layer morphology 0.0316570406711787 0.166132676518053 1.26830732292917 0.428571428571429 17.4 17 4 increased bone resorption 0.0316570406711787 0.166132676518053 1.26830732292917 0.428571428571429 17.4 17 4 hypoxia 0.0316570406711787 0.166132676518053 1.26830732292917 0.428571428571429 17.4 17 4 increased triglyceride level 0.0316570406711787 0.166132676518053 1.26830732292917 0.428571428571429 17.4 17 4 abnormal interparietal bone morphology 0.116194963861195 0.394385347064008 1.26830732292917 0.428571428571429 17.4 17 4 midline facial cleft 0.116194963861195 0.394385347064008 1.26830732292917 0.428571428571429 17.4 17 4 megacephaly 0.116194963861195 0.394385347064008 1.26830732292917 0.428571428571429 17.4 17 4 intestinal obstruction 0.116194963861195 0.394385347064008 1.26830732292917 0.428571428571429 17.4 17 4 absent olfactory bulb 0.116194963861195 0.394385347064008 1.26830732292917 0.428571428571429 17.4 17 4 abnormal sagittal suture morphology 0.116194963861195 0.394385347064008 1.26830732292917 0.428571428571429 17.4 17 4 decreased CNS synapse formation 0.116194963861195 0.394385347064008 1.26830732292917 0.428571428571429 17.4 17 4 lysosomal protein accumulation 0.116194963861195 0.394385347064008 1.26830732292917 0.428571428571429 17.4 17 4 decreased compact bone area 0.116194963861195 0.394385347064008 1.26830732292917 0.428571428571429 17.4 17 4 multiple persisting craniopharyngeal ducts 0.116194963861195 0.394385347064008 1.26830732292917 0.428571428571429 17.4 17 4 polydactyly 0.000106400333772607 0.00202038801724703 1.26830732292917 0.428571428571429 17.4 17 4 abnormal reproductive system morphology 0.00955105465761252 0.0684121952473409 1.26830732292917 0.428571428571429 17.4 17 4 abnormal salivary gland morphology 0.0594357097041638 0.258826972679877 1.26830732292917 0.428571428571429 17.4 17 4 abnormal clavicle morphology 0.0594357097041638 0.258826972679877 1.26830732292917 0.428571428571429 17.4 17 4 increased keratinocyte proliferation 0.0594357097041638 0.258826972679877 1.26830732292917 0.428571428571429 17.4 17 4 abnormal tumor vascularization 0.0594357097041638 0.258826972679877 1.26830732292917 0.428571428571429 17.4 17 4 increased bone ossification 0.0594357097041638 0.258826972679877 1.26830732292917 0.428571428571429 17.4 17 4 skin lesions 0.00170910625529189 0.0179763290065056 1.26830732292917 0.428571428571429 17.4 17 4 decreased susceptibility to hepatic steatosis 0.00170910625529189 0.0179763290065056 1.26830732292917 0.428571428571429 17.4 17 4 abnormal embryonic epiblast morphology 0.017257259009957 0.103654189227817 1.26830732292917 0.428571428571429 17.4 17 4 decreased circulating thyroxine level 0.017257259009957 0.103654189227817 1.26830732292917 0.428571428571429 17.4 17 4 postnatal growth retardation 1.03781610762686e-21 5.16313513544363e-19 1.26692572453818 0.428104575163399 17.4 17 4 cleft palate 9.16917186326898e-06 0.000237586614686267 1.26508007783266 0.427480916030534 17.4 17 4 increased cell proliferation 0.00400230102149864 0.0350654591860232 1.26047826538023 0.425925925925926 17.4 17 4 abnormal mandible morphology 0.00400230102149864 0.0350654591860232 1.26047826538023 0.425925925925926 17.4 17 4 abnormal tooth development 0.0231968049699213 0.132648396236044 1.25549613784908 0.424242424242424 17.4 17 4 belly spot 0.0231968049699213 0.132648396236044 1.25549613784908 0.424242424242424 17.4 17 4 abnormal skeleton physiology 0.0231968049699213 0.132648396236044 1.25549613784908 0.424242424242424 17.4 17 4 decreased body weight 3.84336594767679e-41 9.56037279484603e-38 1.25498907155754 0.424071082390953 17.4 17 4 increased hemoglobin content 0.00300147180470479 0.0282248501494145 1.25397616673788 0.423728813559322 17.4 17 4 abnormal erythrocyte osmotic lysis 0.0428721906601459 0.209723843199829 1.25204697263521 0.423076923076923 17.4 17 4 abnormal Mullerian duct morphology 0.0428721906601459 0.209723843199829 1.25204697263521 0.423076923076923 17.4 17 4 decreased bone resorption 0.0428721906601459 0.209723843199829 1.25204697263521 0.423076923076923 17.4 17 4 abnormal ovary morphology 0.00128396692027933 0.0149946841042011 1.25044383950763 0.422535211267606 17.4 17 4 decreased insulin secretion 0.000319106758896351 0.00493029852642653 1.2495175848117 0.422222222222222 17.4 17 4 cardiomyopathy 0.00947968366979429 0.0684121952473409 1.2495175848117 0.422222222222222 17.4 17 4 abnormal osteoclast physiology 0.00225331412117988 0.0225709021479401 1.2484900210084 0.421875 17.4 17 4 abnormal frontal bone morphology 0.0170758040774415 0.103097239423873 1.24605631726375 0.421052631578947 17.4 17 4 enlarged adrenal glands 0.0814647712522954 0.308907955015373 1.24605631726375 0.421052631578947 17.4 17 4 small superior vagus ganglion 0.0814647712522954 0.308907955015373 1.24605631726375 0.421052631578947 17.4 17 4 thin dermal layer 0.0814647712522954 0.308907955015373 1.24605631726375 0.421052631578947 17.4 17 4 oliguria 0.0814647712522954 0.308907955015373 1.24605631726375 0.421052631578947 17.4 17 4 increased left ventricle weight 0.0814647712522954 0.308907955015373 1.24605631726375 0.421052631578947 17.4 17 4 absent amnion 0.0814647712522954 0.308907955015373 1.24605631726375 0.421052631578947 17.4 17 4 decreased circulating magnesium level 0.0814647712522954 0.308907955015373 1.24605631726375 0.421052631578947 17.4 17 4 shortened RR interval 0.0814647712522954 0.308907955015373 1.24605631726375 0.421052631578947 17.4 17 4 embryonic lethality between implantation and somite formation, incomplete penetrance 0.0814647712522954 0.308907955015373 1.24605631726375 0.421052631578947 17.4 17 4 impaired natural killer cell mediated cytotoxicity 0.00397409097166631 0.0350654591860232 1.24605631726375 0.421052631578947 17.4 17 4 infertility 0.000105786485124137 0.00201939385328656 1.24460064399592 0.420560747663551 17.4 17 4 abnormal interventricular septum morphology 0.00705276087647874 0.0536505892362106 1.24294117647059 0.42 17.4 17 4 kidney inflammation 0.00705276087647874 0.0536505892362106 1.24294117647059 0.42 17.4 17 4 decreased respiratory quotient 0.00705276087647874 0.0536505892362106 1.24294117647059 0.42 17.4 17 4 decreased body length 9.87245306991897e-10 5.84707785986272e-08 1.24207712281993 0.41970802919708 17.4 17 4 lethargy 0.000317014480848977 0.0049132306611329 1.24103189662962 0.419354838709677 17.4 17 4 abnormal cranial ganglia morphology 0.031180057739116 0.165550466651123 1.24103189662962 0.419354838709677 17.4 17 4 absent mature ovarian follicles 0.031180057739116 0.165550466651123 1.24103189662962 0.419354838709677 17.4 17 4 abnormal object recognition memory 0.031180057739116 0.165550466651123 1.24103189662962 0.419354838709677 17.4 17 4 abnormal capillary morphology 0.031180057739116 0.165550466651123 1.24103189662962 0.419354838709677 17.4 17 4 small cranium 0.031180057739116 0.165550466651123 1.24103189662962 0.419354838709677 17.4 17 4 abnormal intestine morphology 0.00127370694926453 0.014934246093666 1.23974184268302 0.418918918918919 17.4 17 4 kidney cysts 0.00127370694926453 0.014934246093666 1.23974184268302 0.418918918918919 17.4 17 4 abnormal male reproductive system morphology 0.0126177734377536 0.0856390489124474 1.23881180379128 0.418604651162791 17.4 17 4 decreased oxygen consumption 0.0126177734377536 0.0856390489124474 1.23881180379128 0.418604651162791 17.4 17 4 cardiac hypertrophy 0.000239778496910036 0.00400301349707192 1.2381095295261 0.418367346938776 17.4 17 4 abnormal learning/memory/conditioning 0.00525830172458835 0.0423301797408204 1.23756047873695 0.418181818181818 17.4 17 4 hunched posture 0.000958892220243068 0.0118081405834388 1.23619827677907 0.417721518987342 17.4 17 4 abnormal placenta labyrinth morphology 0.000958892220243068 0.0118081405834388 1.23619827677907 0.417721518987342 17.4 17 4 abnormal vitelline vasculature morphology 7.95955314945283e-05 0.00157138003644952 1.23522104493971 0.417391304347826 17.4 17 4 abnormal eye morphology 1.54949973204593e-05 0.000374211707132452 1.23485077484231 0.41726618705036 17.4 17 4 abnormal forebrain development 0.00167537382295381 0.0178862334102902 1.23307656395892 0.416666666666667 17.4 17 4 abnormal eating behavior 0.003927726910639 0.0350187121513065 1.23307656395892 0.416666666666667 17.4 17 4 abnormal incisor morphology 0.003927726910639 0.0350187121513065 1.23307656395892 0.416666666666667 17.4 17 4 curly tail 0.0093533045713812 0.0684121952473409 1.23307656395892 0.416666666666667 17.4 17 4 thymus atrophy 0.0093533045713812 0.0684121952473409 1.23307656395892 0.416666666666667 17.4 17 4 abnormal foregut morphology 0.0580945986734388 0.258826972679877 1.23307656395892 0.416666666666667 17.4 17 4 abnormal adrenal gland morphology 0.0580945986734388 0.258826972679877 1.23307656395892 0.416666666666667 17.4 17 4 decreased body height 0.0580945986734388 0.258826972679877 1.23307656395892 0.416666666666667 17.4 17 4 abnormal vasodilation 0.0580945986734388 0.258826972679877 1.23307656395892 0.416666666666667 17.4 17 4 increased circulating total protein level 0.0580945986734388 0.258826972679877 1.23307656395892 0.416666666666667 17.4 17 4 abnormal cellular extravasation 0.0580945986734388 0.258826972679877 1.23307656395892 0.416666666666667 17.4 17 4 abnormal inner cell mass apoptosis 0.0580945986734388 0.258826972679877 1.23307656395892 0.416666666666667 17.4 17 4 abnormal rectum morphology 0.162946300678993 0.489232254603493 1.23307656395892 0.416666666666667 17.4 17 4 amyloidosis 0.162946300678993 0.489232254603493 1.23307656395892 0.416666666666667 17.4 17 4 mesocardia 0.162946300678993 0.489232254603493 1.23307656395892 0.416666666666667 17.4 17 4 abnormal pilomotor reflex 0.162946300678993 0.489232254603493 1.23307656395892 0.416666666666667 17.4 17 4 abnormal thymus involution 0.162946300678993 0.489232254603493 1.23307656395892 0.416666666666667 17.4 17 4 increased papilloma incidence 0.162946300678993 0.489232254603493 1.23307656395892 0.416666666666667 17.4 17 4 small thyroid gland 0.162946300678993 0.489232254603493 1.23307656395892 0.416666666666667 17.4 17 4 dilated bile duct 0.162946300678993 0.489232254603493 1.23307656395892 0.416666666666667 17.4 17 4 increased fear-related response 0.162946300678993 0.489232254603493 1.23307656395892 0.416666666666667 17.4 17 4 increased hepatocyte proliferation 0.162946300678993 0.489232254603493 1.23307656395892 0.416666666666667 17.4 17 4 hematuria 0.162946300678993 0.489232254603493 1.23307656395892 0.416666666666667 17.4 17 4 abnormal fatty acid level 0.162946300678993 0.489232254603493 1.23307656395892 0.416666666666667 17.4 17 4 abnormal thymus corticomedullary boundary morphology 0.162946300678993 0.489232254603493 1.23307656395892 0.416666666666667 17.4 17 4 increased skeletal muscle glycogen level 0.162946300678993 0.489232254603493 1.23307656395892 0.416666666666667 17.4 17 4 decreased grip strength 9.0956381163783e-08 3.77089996908184e-06 1.22969827200287 0.415525114155251 17.4 17 4 enlarged kidney 0.00695214067365722 0.0533483385715407 1.22842344484964 0.415094339622642 17.4 17 4 decreased body size 2.88056208558408e-24 1.59231070842009e-21 1.22751381254256 0.414786967418546 17.4 17 4 sparse hair 0.000947229627985687 0.0117517890255082 1.22706155632985 0.414634146341463 17.4 17 4 thick ventricular wall 0.0167840269714006 0.101458729262112 1.22706155632985 0.414634146341463 17.4 17 4 abnormal motor coordination/ balance 0.000310295412136319 0.0048851888461335 1.2256033726622 0.414141414141414 17.4 17 4 hypoactivity 4.3858134304844e-12 4.36388436333198e-10 1.22457258765575 0.413793103448276 17.4 17 4 increased blood urea nitrogen level 1.51732813664056e-05 0.000370034680381706 1.22457258765575 0.413793103448276 17.4 17 4 enlarged heart 5.22539125608507e-08 2.32110013384136e-06 1.22457258765575 0.413793103448276 17.4 17 4 abnormal spermiogenesis 0.00517936454871811 0.0418300951783646 1.22457258765575 0.413793103448276 17.4 17 4 enlarged epididymis 0.0419055427887626 0.206825471601284 1.22457258765575 0.413793103448276 17.4 17 4 decreased bone strength 0.0419055427887626 0.206825471601284 1.22457258765575 0.413793103448276 17.4 17 4 perinatal lethality, complete penetrance 1.99174449020884e-07 7.80230617227479e-06 1.22265619862969 0.413145539906103 17.4 17 4 abnormal locomotor behavior 0.00053746369862675 0.007427449724078 1.22235415905493 0.41304347826087 17.4 17 4 abnormal sleep pattern 0.012394568608327 0.0848184027873819 1.22235415905493 0.41304347826087 17.4 17 4 abnormal renal glomerulus morphology 0.000177165100503426 0.00310350836269205 1.22176393493177 0.412844036697248 17.4 17 4 abnormal oocyte morphology 0.0304793350661697 0.163268004180209 1.21856978085352 0.411764705882353 17.4 17 4 absence seizures 0.11189165884137 0.390877985919531 1.21856978085352 0.411764705882353 17.4 17 4 abnormal testis development 0.11189165884137 0.390877985919531 1.21856978085352 0.411764705882353 17.4 17 4 abnormal survival 0.11189165884137 0.390877985919531 1.21856978085352 0.411764705882353 17.4 17 4 delayed heart development 0.11189165884137 0.390877985919531 1.21856978085352 0.411764705882353 17.4 17 4 decreased body fat mass 0.11189165884137 0.390877985919531 1.21856978085352 0.411764705882353 17.4 17 4 abnormal cell cytoskeleton morphology 0.11189165884137 0.390877985919531 1.21856978085352 0.411764705882353 17.4 17 4 thin ventricular wall 0.000702241395993645 0.00929162485390528 1.21663554310613 0.411111111111111 17.4 17 4 decreased percent body fat/body weight 0.00216545606334205 0.0219412299697082 1.21618510417866 0.410958904109589 17.4 17 4 abnormal eye development 0.00682349712475979 0.0527666183416042 1.21546118447379 0.410714285714286 17.4 17 4 abnormal heart ventricle morphology 0.00162404923986362 0.0174487680324502 1.21410615528263 0.41025641025641 17.4 17 4 abnormal brain morphology 8.50035338689247e-06 0.000223752688358677 1.21316352628008 0.409937888198758 17.4 17 4 abnormal maternal nurturing 0.00508203559327933 0.0411107757342515 1.21286219405795 0.409836065573771 17.4 17 4 abnormal lipid level 0.00121948764473785 0.0144451215061209 1.2122776821572 0.409638554216867 17.4 17 4 abnormal astrocyte morphology 0.0164097459036574 0.0996806909288101 1.21065699006875 0.409090909090909 17.4 17 4 increased myocardial infarction size 0.0787620210272887 0.304697554129675 1.21065699006875 0.409090909090909 17.4 17 4 prolonged PR interval 0.0787620210272887 0.304697554129675 1.21065699006875 0.409090909090909 17.4 17 4 abnormal circulating lipid level 0.0787620210272887 0.304697554129675 1.21065699006875 0.409090909090909 17.4 17 4 abnormal cerebral cortex pyramidal cell morphology 0.0787620210272887 0.304697554129675 1.21065699006875 0.409090909090909 17.4 17 4 increased circulating creatine kinase level 0.0787620210272887 0.304697554129675 1.21065699006875 0.409090909090909 17.4 17 4 rough coat 0.0787620210272887 0.304697554129675 1.21065699006875 0.409090909090909 17.4 17 4 hypoglycemia 0.000689774067273209 0.00915100262582458 1.20921056594681 0.408602150537634 17.4 17 4 abnormal enzyme/coenzyme activity 1.42787294039679e-05 0.000351666726657131 1.2063729950579 0.407643312101911 17.4 17 4 abnormal trigeminal nerve morphology 0.056304843106193 0.255390988750305 1.20567486253761 0.407407407407407 17.4 17 4 abnormal trigeminal ganglion morphology 0.056304843106193 0.255390988750305 1.20567486253761 0.407407407407407 17.4 17 4 abnormal glucose homeostasis 3.59216728133463e-06 0.000103853111717194 1.20326592175332 0.406593406593407 17.4 17 4 decreased caudal vertebrae number 0.00497005472553353 0.0404019971560937 1.20224964985994 0.40625 17.4 17 4 abnormal tooth morphology 0.00497005472553353 0.0404019971560937 1.20224964985994 0.40625 17.4 17 4 polydipsia 0.0406816872816623 0.201184288495298 1.20224964985994 0.40625 17.4 17 4 abnormal depression-related behavior 0.0406816872816623 0.201184288495298 1.20224964985994 0.40625 17.4 17 4 abnormal cardiovascular system physiology 7.27563705981214e-05 0.00147139408018558 1.2015543059329 0.406015037593985 17.4 17 4 decreased litter size 1.18018026258041e-08 6.0529863982861e-07 1.20060408505039 0.405693950177936 17.4 17 4 abnormal long bone metaphysis morphology 0.0296243900780473 0.158987422479272 1.19975017033841 0.405405405405405 17.4 17 4 abnormal chromosome morphology 0.0296243900780473 0.158987422479272 1.19975017033841 0.405405405405405 17.4 17 4 increased trabecular bone volume 0.0296243900780473 0.158987422479272 1.19975017033841 0.405405405405405 17.4 17 4 abnormal pancreas morphology 0.0217024481447765 0.125109709756968 1.19784580498866 0.404761904761905 17.4 17 4 decreased bone trabecula number 0.0159748857420466 0.0986927394299759 1.19634662375589 0.404255319148936 17.4 17 4 cachexia 0.000497998185603517 0.00700902363655512 1.19513574660633 0.403846153846154 17.4 17 4 abnormal skin condition 0.0118045735363008 0.0814531946506193 1.19513574660633 0.403846153846154 17.4 17 4 increased circulating cholesterol level 7.73829466504518e-06 0.00020697858042258 1.19384230965113 0.403409090909091 17.4 17 4 abnormal lung morphology 0.000213647668801473 0.00366516259409424 1.19370100981569 0.403361344537815 17.4 17 4 azoospermia 2.2911290130073e-05 0.000542106920362126 1.19119849197541 0.40251572327044 17.4 17 4 decreased startle reflex 0.000276477867433886 0.00439449645521911 1.18881227704757 0.401709401709402 17.4 17 4 hyperactivity 1.76276199684308e-10 1.21801957420755e-08 1.1885395667701 0.401617250673854 17.4 17 4 limb grasping 7.39659745207906e-06 0.000199989523500507 1.18700557145935 0.401098901098901 17.4 17 4 weight loss 1.25547505766227e-05 0.000313868764415567 1.18375350140056 0.4 17.4 17 4 abnormal nervous system physiology 0.000357427622160185 0.00547139206229822 1.18375350140056 0.4 17.4 17 4 abnormal lung development 0.00197374677314996 0.0202045065769981 1.18375350140056 0.4 17.4 17 4 abnormal social investigation 0.00263429086058188 0.0253984438592923 1.18375350140056 0.4 17.4 17 4 abnormal retinal pigment epithelium morphology 0.00263429086058188 0.0253984438592923 1.18375350140056 0.4 17.4 17 4 domed cranium 0.00471442196002032 0.0392211525938145 1.18375350140056 0.4 17.4 17 4 increased erythrocyte cell number 0.0085028099196433 0.0627618387985541 1.18375350140056 0.4 17.4 17 4 increased circulating chloride level 0.0154967452328668 0.0986927394299759 1.18375350140056 0.4 17.4 17 4 perinatal lethality 0.028666204340943 0.154787312971888 1.18375350140056 0.4 17.4 17 4 increased susceptibility to weight loss 0.028666204340943 0.154787312971888 1.18375350140056 0.4 17.4 17 4 abnormal dermal layer morphology 0.0392940524369784 0.196667918384273 1.18375350140056 0.4 17.4 17 4 decreased bone volume 0.0392940524369784 0.196667918384273 1.18375350140056 0.4 17.4 17 4 abnormal response to new environment 0.0542490825759591 0.247151269061718 1.18375350140056 0.4 17.4 17 4 salivary gland inflammation 0.0542490825759591 0.247151269061718 1.18375350140056 0.4 17.4 17 4 enhanced paired-pulse facilitation 0.0542490825759591 0.247151269061718 1.18375350140056 0.4 17.4 17 4 abnormal synaptic transmission 0.0542490825759591 0.247151269061718 1.18375350140056 0.4 17.4 17 4 abnormal brain vasculature morphology 0.0542490825759591 0.247151269061718 1.18375350140056 0.4 17.4 17 4 abnormal cochlear outer hair cell morphology 0.0756145677515657 0.295508621024383 1.18375350140056 0.4 17.4 17 4 small gonad 0.106820328786511 0.37556970721759 1.18375350140056 0.4 17.4 17 4 brain inflammation 0.106820328786511 0.37556970721759 1.18375350140056 0.4 17.4 17 4 anencephaly 0.106820328786511 0.37556970721759 1.18375350140056 0.4 17.4 17 4 abnormal dopamine level 0.106820328786511 0.37556970721759 1.18375350140056 0.4 17.4 17 4 abnormal optic stalk morphology 0.106820328786511 0.37556970721759 1.18375350140056 0.4 17.4 17 4 decreased circulating VLDL cholesterol level 0.106820328786511 0.37556970721759 1.18375350140056 0.4 17.4 17 4 abnormal response to tactile stimuli 0.106820328786511 0.37556970721759 1.18375350140056 0.4 17.4 17 4 abnormal circulating cytokine level 0.106820328786511 0.37556970721759 1.18375350140056 0.4 17.4 17 4 abnormal bronchus morphology 0.154024318727514 0.483336421994481 1.18375350140056 0.4 17.4 17 4 joint inflammation 0.154024318727514 0.483336421994481 1.18375350140056 0.4 17.4 17 4 abnormal pericyte morphology 0.154024318727514 0.483336421994481 1.18375350140056 0.4 17.4 17 4 abnormal olfactory nerve morphology 0.154024318727514 0.483336421994481 1.18375350140056 0.4 17.4 17 4 absent chorion 0.154024318727514 0.483336421994481 1.18375350140056 0.4 17.4 17 4 abnormal aorta wall morphology 0.154024318727514 0.483336421994481 1.18375350140056 0.4 17.4 17 4 lactation failure 0.154024318727514 0.483336421994481 1.18375350140056 0.4 17.4 17 4 small testis 6.42374582639947e-08 2.77896830315977e-06 1.17946453943896 0.398550724637681 17.4 17 4 short snout 0.000612633266038127 0.00823720043035898 1.1782731611163 0.398148148148148 17.4 17 4 increased or absent threshold for auditory brainstem response 3.62165157245583e-08 1.66830709008961e-06 1.17760945208533 0.397923875432526 17.4 17 4 male infertility 4.51378267835228e-13 5.61401720620065e-11 1.17669334135245 0.397614314115308 17.4 17 4 ataxia 4.93685086231468e-06 0.000135695210165832 1.17203316970352 0.396039603960396 17.4 17 4 impaired coordination 2.77877677261171e-09 1.57095618678901e-07 1.17177911627079 0.395953757225434 17.4 17 4 abnormal osteoclast morphology 0.0203131630607585 0.119595249973105 1.17142273576097 0.395833333333333 17.4 17 4 abnormal locomotor activation 0.0018618657218741 0.0190985195181931 1.17074522116539 0.395604395604396 17.4 17 4 increased grooming behavior 0.0378082505132249 0.194918182697714 1.16817779743476 0.394736842105263 17.4 17 4 abnormal blood homeostasis 0.00057801524795686 0.0078748905324385 1.16817779743476 0.394736842105263 17.4 17 4 abnormal vertebrae morphology 0.000767243310298068 0.00998991374303438 1.16746331560147 0.394495412844037 17.4 17 4 abnormal locomotor coordination 0.0520468607842941 0.239468002514514 1.16581784228843 0.393939393939394 17.4 17 4 decreased sensitivity to xenobiotic induced morbidity/mortality 0.0520468607842941 0.239468002514514 1.16581784228843 0.393939393939394 17.4 17 4 respiratory distress 3.22508810778909e-05 0.000718805949617131 1.16322598403523 0.393063583815029 17.4 17 4 reduced long term potentiation 0.000743575143764638 0.00976064997421919 1.16261504601841 0.392857142857143 17.4 17 4 abnormal circulating cholesterol level 0.0722534211523787 0.285453993253742 1.16261504601841 0.392857142857143 17.4 17 4 reddish skin 0.0722534211523787 0.285453993253742 1.16261504601841 0.392857142857143 17.4 17 4 abnormal spleen germinal center morphology 0.0722534211523787 0.285453993253742 1.16261504601841 0.392857142857143 17.4 17 4 abnormal renal tubule epithelium morphology 0.0722534211523787 0.285453993253742 1.16261504601841 0.392857142857143 17.4 17 4 distended abdomen 0.0195697586547107 0.115628918417085 1.16054264843192 0.392156862745098 17.4 17 4 abnormal myocardial fiber morphology 0.00174576430464863 0.0183231591046982 1.15934621271189 0.391752577319588 17.4 17 4 postnatal lethality 5.44462862136151e-05 0.00113334842641312 1.1587948432385 0.391566265060241 17.4 17 4 increased sensitivity to induced morbidity/mortality 2.2991871396263e-05 0.000542106920362126 1.15801972963098 0.391304347826087 17.4 17 4 fragile skeleton 0.101464658825655 0.371166674748259 1.15801972963098 0.391304347826087 17.4 17 4 abnormal blood vessel physiology 0.101464658825655 0.371166674748259 1.15801972963098 0.391304347826087 17.4 17 4 abnormal pulmonary artery morphology 0.101464658825655 0.371166674748259 1.15801972963098 0.391304347826087 17.4 17 4 blistering 0.101464658825655 0.371166674748259 1.15801972963098 0.391304347826087 17.4 17 4 abnormal circulating insulin level 0.101464658825655 0.371166674748259 1.15801972963098 0.391304347826087 17.4 17 4 failure of embryo implantation 0.101464658825655 0.371166674748259 1.15801972963098 0.391304347826087 17.4 17 4 abnormal cardiovascular development 0.101464658825655 0.371166674748259 1.15801972963098 0.391304347826087 17.4 17 4 abnormal ulna morphology 0.101464658825655 0.371166674748259 1.15801972963098 0.391304347826087 17.4 17 4 abnormal hepatocyte physiology 0.101464658825655 0.371166674748259 1.15801972963098 0.391304347826087 17.4 17 4 decreased effector memory CD8-positive, alpha-beta T cell number 0.101464658825655 0.371166674748259 1.15801972963098 0.391304347826087 17.4 17 4 increased sensitivity to xenobiotic induced morbidity/mortality 0.000955360653836511 0.0118081405834388 1.15685001273237 0.390909090909091 17.4 17 4 abnormal mammary gland development 0.0362707978574502 0.187965853480015 1.15488146478103 0.390243902439024 17.4 17 4 scaly skin 0.0362707978574502 0.187965853480015 1.15488146478103 0.390243902439024 17.4 17 4 increased circulating glucose level 0.000219000871850565 0.00371853016196778 1.15436954923813 0.390070921985816 17.4 17 4 decreased heart rate 0.00168721079360706 0.0179313895950765 1.15415966386555 0.39 17.4 17 4 no abnormal phenotype detected 2.99020827955491e-38 4.95876206359523e-35 1.15305096101841 0.389625360230548 17.4 17 4 impaired limb coordination 0.0188127817092525 0.111288453036304 1.15087145969499 0.388888888888889 17.4 17 4 neurodegeneration 0.0188127817092525 0.111288453036304 1.15087145969499 0.388888888888889 17.4 17 4 abnormal uterus morphology 0.0497777844345295 0.239468002514514 1.15087145969499 0.388888888888889 17.4 17 4 renal hypoplasia 0.0497777844345295 0.239468002514514 1.15087145969499 0.388888888888889 17.4 17 4 underdeveloped hair follicles 0.144886789943981 0.470811090771591 1.15087145969499 0.388888888888889 17.4 17 4 right pulmonary isomerism 0.144886789943981 0.470811090771591 1.15087145969499 0.388888888888889 17.4 17 4 abnormal metacarpal bone morphology 0.144886789943981 0.470811090771591 1.15087145969499 0.388888888888889 17.4 17 4 increased circulating renin level 0.144886789943981 0.470811090771591 1.15087145969499 0.388888888888889 17.4 17 4 abnormal body wall morphology 0.144886789943981 0.470811090771591 1.15087145969499 0.388888888888889 17.4 17 4 decreased activity of thyroid 0.144886789943981 0.470811090771591 1.15087145969499 0.388888888888889 17.4 17 4 decreased heart rate variability 0.144886789943981 0.470811090771591 1.15087145969499 0.388888888888889 17.4 17 4 increased susceptibility to autoimmune disorder 0.144886789943981 0.470811090771591 1.15087145969499 0.388888888888889 17.4 17 4 darkened coat color 0.144886789943981 0.470811090771591 1.15087145969499 0.388888888888889 17.4 17 4 increased total body fat amount 0.000370383731926425 0.00560633614379038 1.14841757598562 0.388059701492537 17.4 17 4 decreased compact bone thickness 0.00995032454795499 0.0707183780372515 1.14841757598562 0.388059701492537 17.4 17 4 abnormal respiratory system physiology 0.0255027037220414 0.143767896664731 1.14751614931687 0.387755102040816 17.4 17 4 reduced male fertility 4.77578498895786e-06 0.000132734806257348 1.1472500894631 0.387665198237885 17.4 17 4 abnormal retinal photoreceptor layer morphology 0.0688189929992283 0.27655451548559 1.14556790458119 0.387096774193548 17.4 17 4 preaxial polydactyly 0.0688189929992283 0.27655451548559 1.14556790458119 0.387096774193548 17.4 17 4 abnormal suckling behavior 0.00384393256938265 0.0344860819472843 1.14339826839827 0.386363636363636 17.4 17 4 abnormal blood vessel morphology 0.000261020130711308 0.00420250857698627 1.14293441514537 0.386206896551724 17.4 17 4 abnormal pulmonary alveolus morphology 0.00208748903265247 0.0212812662652583 1.14273234046094 0.386138613861386 17.4 17 4 abnormal craniofacial bone morphology 0.0180523698188806 0.10794536039535 1.1422182908251 0.385964912280702 17.4 17 4 abnormal circulating amino acid level 0.0180523698188806 0.10794536039535 1.1422182908251 0.385964912280702 17.4 17 4 acanthosis 0.0474954197268698 0.229853806557565 1.13822452057746 0.384615384615385 17.4 17 4 abnormal xiphoid process morphology 0.0960785534337032 0.355383496901616 1.13822452057746 0.384615384615385 17.4 17 4 increased susceptibility to otitis media 0.0960785534337032 0.355383496901616 1.13822452057746 0.384615384615385 17.4 17 4 abnormal nerve conduction 0.0960785534337032 0.355383496901616 1.13822452057746 0.384615384615385 17.4 17 4 absent trabeculae carneae 0.212499169760763 0.556129132657845 1.13822452057746 0.384615384615385 17.4 17 4 abnormal renal/urinary system morphology 0.212499169760763 0.556129132657845 1.13822452057746 0.384615384615385 17.4 17 4 uterus hypoplasia 0.212499169760763 0.556129132657845 1.13822452057746 0.384615384615385 17.4 17 4 pup cannibalization 0.212499169760763 0.556129132657845 1.13822452057746 0.384615384615385 17.4 17 4 abnormal digestion 0.212499169760763 0.556129132657845 1.13822452057746 0.384615384615385 17.4 17 4 abnormal pulmonary alveolus epithelial cell morphology 0.212499169760763 0.556129132657845 1.13822452057746 0.384615384615385 17.4 17 4 abnormal tail bud morphology 0.212499169760763 0.556129132657845 1.13822452057746 0.384615384615385 17.4 17 4 abnormal bile duct development 0.212499169760763 0.556129132657845 1.13822452057746 0.384615384615385 17.4 17 4 abnormal GABAergic neuron morphology 0.212499169760763 0.556129132657845 1.13822452057746 0.384615384615385 17.4 17 4 tracheoesophageal fistula 0.212499169760763 0.556129132657845 1.13822452057746 0.384615384615385 17.4 17 4 abnormal vestibulocochlear ganglion morphology 0.212499169760763 0.556129132657845 1.13822452057746 0.384615384615385 17.4 17 4 abnormal retinal inner plexiform layer morphology 0.212499169760763 0.556129132657845 1.13822452057746 0.384615384615385 17.4 17 4 increased cochlear inner hair cell number 0.212499169760763 0.556129132657845 1.13822452057746 0.384615384615385 17.4 17 4 abnormal vertebral arch development 0.212499169760763 0.556129132657845 1.13822452057746 0.384615384615385 17.4 17 4 hyperalgesia 0.212499169760763 0.556129132657845 1.13822452057746 0.384615384615385 17.4 17 4 increased renin activity 0.212499169760763 0.556129132657845 1.13822452057746 0.384615384615385 17.4 17 4 abnormal kidney morphology 9.46257208936285e-05 0.00185339748600709 1.13302120848339 0.382857142857143 17.4 17 4 increased exploration in new environment 0.00658262379181824 0.0511696146317121 1.13260365874745 0.382716049382716 17.4 17 4 hydroencephaly 0.00140117400126799 0.0155873729542299 1.13228595786141 0.382608695652174 17.4 17 4 lung hemorrhage 0.065398186228847 0.264517054055702 1.13152908222112 0.382352941176471 17.4 17 4 impaired synaptic plasticity 0.065398186228847 0.264517054055702 1.13152908222112 0.382352941176471 17.4 17 4 abnormal nervous system development 0.065398186228847 0.264517054055702 1.13152908222112 0.382352941176471 17.4 17 4 increased susceptibility to weight gain 0.065398186228847 0.264517054055702 1.13152908222112 0.382352941176471 17.4 17 4 postnatal lethality, incomplete penetrance 4.79042982829518e-12 4.67301733250363e-10 1.13060963822149 0.382042253521127 17.4 17 4 increased startle reflex 0.00473395602781814 0.0393179152560855 1.13055109684323 0.382022471910112 17.4 17 4 increased circulating insulin level 0.000216488130876732 0.00368845359969774 1.12826505602241 0.38125 17.4 17 4 abnormal retina morphology 2.61338995973327e-05 0.000599152767266039 1.12738428704815 0.380952380952381 17.4 17 4 increased circulating HDL cholesterol level 0.00246552390832626 0.0241456327636283 1.12738428704815 0.380952380952381 17.4 17 4 arrest of spermatogenesis 0.00631307941728098 0.0492281663024653 1.12738428704815 0.380952380952381 17.4 17 4 abnormal associative learning 0.135980094375647 0.445946585048678 1.12738428704815 0.380952380952381 17.4 17 4 vascular ring 0.135980094375647 0.445946585048678 1.12738428704815 0.380952380952381 17.4 17 4 neonatal lethality, incomplete penetrance 3.21299666628964e-06 9.45837776023135e-05 1.12684227537169 0.380769230769231 17.4 17 4 increased circulating free fatty acid level 0.0117882497399879 0.0814531946506193 1.12539945555687 0.380281690140845 17.4 17 4 abnormal visceral yolk sac morphology 0.00843041812352522 0.062599000245579 1.1238166152537 0.379746835443038 17.4 17 4 abnormal myocardium layer morphology 0.00843041812352522 0.062599000245579 1.1238166152537 0.379746835443038 17.4 17 4 female infertility 2.97547371605213e-06 8.81129865319009e-05 1.12367578610392 0.379699248120301 17.4 17 4 abnormal axon morphology 0.0023659475041 0.0234007730276293 1.12346975827368 0.37962962962963 17.4 17 4 abnormal embryonic neuroepithelium morphology 0.0223021797748301 0.128121644780346 1.12252487201777 0.379310344827586 17.4 17 4 lordosis 0.0907993468190331 0.337109515242306 1.12252487201777 0.379310344827586 17.4 17 4 abnormal circulating glucose level 0.0907993468190331 0.337109515242306 1.12252487201777 0.379310344827586 17.4 17 4 increased susceptibility to induced arthritis 0.0907993468190331 0.337109515242306 1.12252487201777 0.379310344827586 17.4 17 4 polychromatophilia 0.0907993468190331 0.337109515242306 1.12252487201777 0.379310344827586 17.4 17 4 impaired swimming 0.0158191639647342 0.0986927394299759 1.12097869450811 0.378787878787879 17.4 17 4 abnormal breathing pattern 0.0620450679558666 0.258826972679877 1.11976682564918 0.378378378378378 17.4 17 4 abnormal respiratory electron transport chain 0.0620450679558666 0.258826972679877 1.11976682564918 0.378378378378378 17.4 17 4 albuminuria 0.0430236493875095 0.210258011495933 1.11798941798942 0.377777777777778 17.4 17 4 abnormal long bone morphology 0.0212756315595806 0.122791493049784 1.11583321853332 0.377049180327869 17.4 17 4 abnormal male meiosis 0.0212756315595806 0.122791493049784 1.11583321853332 0.377049180327869 17.4 17 4 abnormal coat appearance 0.0151058704302148 0.0974730290406209 1.11513011001502 0.376811594202899 17.4 17 4 obese 0.010775098780899 0.0756380493879186 1.11457310196806 0.376623376623377 17.4 17 4 cardiac fibrosis 0.00771495927148395 0.0581544278418677 1.11412094249464 0.376470588235294 17.4 17 4 abnormal crypts of Lieberkuhn morphology 0.0857013764297679 0.319134990821928 1.10976890756303 0.375 17.4 17 4 abnormal lumbar vertebrae morphology 0.0857013764297679 0.319134990821928 1.10976890756303 0.375 17.4 17 4 abnormal digestive system morphology 0.127486694916984 0.420309017370442 1.10976890756303 0.375 17.4 17 4 abnormal startle reflex 0.127486694916984 0.420309017370442 1.10976890756303 0.375 17.4 17 4 abnormal primitive streak formation 0.127486694916984 0.420309017370442 1.10976890756303 0.375 17.4 17 4 abnormal cardiac muscle contractility 0.127486694916984 0.420309017370442 1.10976890756303 0.375 17.4 17 4 abnormal mouth morphology 0.196440520523347 0.549967129771329 1.10976890756303 0.375 17.4 17 4 reduced male mating frequency 0.196440520523347 0.549967129771329 1.10976890756303 0.375 17.4 17 4 disorganized yolk sac vascular plexus 0.196440520523347 0.549967129771329 1.10976890756303 0.375 17.4 17 4 abnormal epicardium morphology 0.196440520523347 0.549967129771329 1.10976890756303 0.375 17.4 17 4 large intestinal inflammation 0.196440520523347 0.549967129771329 1.10976890756303 0.375 17.4 17 4 increased pancreatic beta cell number 0.196440520523347 0.549967129771329 1.10976890756303 0.375 17.4 17 4 abnormal molar crown morphology 0.196440520523347 0.549967129771329 1.10976890756303 0.375 17.4 17 4 increased thymus weight 0.196440520523347 0.549967129771329 1.10976890756303 0.375 17.4 17 4 impaired somite development 0.196440520523347 0.549967129771329 1.10976890756303 0.375 17.4 17 4 abnormal thoracic cage shape 0.196440520523347 0.549967129771329 1.10976890756303 0.375 17.4 17 4 decreased midbrain size 0.196440520523347 0.549967129771329 1.10976890756303 0.375 17.4 17 4 decreased fibroblast apoptosis 0.196440520523347 0.549967129771329 1.10976890756303 0.375 17.4 17 4 decreased adipocyte glucose uptake 0.196440520523347 0.549967129771329 1.10976890756303 0.375 17.4 17 4 abnormal posture 0.0102894915517911 0.0730245655779751 1.10976890756303 0.375 17.4 17 4 abnormal pancreatic beta cell morphology 0.0587929489584257 0.258826972679877 1.10976890756303 0.375 17.4 17 4 short tail 0.00981924523346232 0.0698866166473176 1.1053120043198 0.373493975903614 17.4 17 4 abnormal limb morphology 0.0137419349841482 0.0904313843202871 1.10483660130719 0.373333333333333 17.4 17 4 kinked tail 0.0048352642913807 0.0397401040892883 1.10251551601033 0.372549019607843 17.4 17 4 impaired balance 0.0048352642913807 0.0397401040892883 1.10251551601033 0.372549019607843 17.4 17 4 abnormal extraembryonic tissue morphology 0.0048352642913807 0.0397401040892883 1.10251551601033 0.372549019607843 17.4 17 4 abnormal gluconeogenesis 0.0387993553557793 0.19535134655283 1.10251551601033 0.372549019607843 17.4 17 4 abnormal thrombosis 0.0387993553557793 0.19535134655283 1.10251551601033 0.372549019607843 17.4 17 4 increased circulating creatinine level 0.00936498401054043 0.0684121952473409 1.10116604781447 0.372093023255814 17.4 17 4 abnormal organ of Corti morphology 0.0556617188866261 0.253123447404904 1.10116604781447 0.372093023255814 17.4 17 4 cataract 0.00240834723421788 0.0236789080834663 1.10059726369887 0.371900826446281 17.4 17 4 abnormal bone mineralization 0.00240834723421788 0.0236789080834663 1.10059726369887 0.371900826446281 17.4 17 4 abnormal cornea morphology 0.013094078987058 0.0882697059086907 1.10028370322488 0.371794871794872 17.4 17 4 decreased glycogen level 0.0808233561967693 0.308907955015373 1.09919967987195 0.371428571428571 17.4 17 4 respiratory failure 0.000839981003585228 0.0106877378333415 1.09751980262304 0.370860927152318 17.4 17 4 abnormal chondrocyte morphology 0.0368039991190975 0.19013488641486 1.09606805685237 0.37037037037037 17.4 17 4 abnormal neuronal precursor proliferation 0.0368039991190975 0.19013488641486 1.09606805685237 0.37037037037037 17.4 17 4 cryptorchism 0.119474853626356 0.396258264527414 1.09606805685237 0.37037037037037 17.4 17 4 decreased susceptibility to pharmacologically induced seizures 0.119474853626356 0.396258264527414 1.09606805685237 0.37037037037037 17.4 17 4 hydronephrosis 0.0118700214655683 0.0817913528964023 1.0921535280779 0.369047619047619 17.4 17 4 abnormal gait 3.61137453810546e-06 0.000103853111717194 1.0918114818743 0.368932038834951 17.4 17 4 abnormal reproductive system physiology 0.0761832114640741 0.29676742436893 1.09029927760578 0.368421052631579 17.4 17 4 kyphoscoliosis 0.181882967514131 0.515007264304383 1.09029927760578 0.368421052631579 17.4 17 4 irregular coat pigmentation 0.181882967514131 0.515007264304383 1.09029927760578 0.368421052631579 17.4 17 4 abnormal stationary movement 0.181882967514131 0.515007264304383 1.09029927760578 0.368421052631579 17.4 17 4 abnormal neurotransmitter level 0.181882967514131 0.515007264304383 1.09029927760578 0.368421052631579 17.4 17 4 abnormal sternebra morphology 0.181882967514131 0.515007264304383 1.09029927760578 0.368421052631579 17.4 17 4 decreased fertilization frequency 0.181882967514131 0.515007264304383 1.09029927760578 0.368421052631579 17.4 17 4 absent kidney 0.0498003269350013 0.239468002514514 1.08712056251072 0.36734693877551 17.4 17 4 abnormal craniofacial development 0.0498003269350013 0.239468002514514 1.08712056251072 0.36734693877551 17.4 17 4 increased fluid intake 0.0498003269350013 0.239468002514514 1.08712056251072 0.36734693877551 17.4 17 4 abnormal lens morphology 0.00263306003602574 0.0253984438592923 1.0866487219888 0.3671875 17.4 17 4 abnormal pain threshold 0.111960026117655 0.390877985919531 1.08510737628385 0.366666666666667 17.4 17 4 neonatal lethality, complete penetrance 4.16467792149945e-08 1.88357024176907e-06 1.08380940095336 0.366228070175439 17.4 17 4 increased body weight 0.000105032065924559 0.00201750783001807 1.08334583833533 0.366071428571429 17.4 17 4 abnormal developmental patterning 0.0150096722668906 0.0974263484853267 1.08270137323222 0.365853658536585 17.4 17 4 Leydig cell hyperplasia 0.0717864976705267 0.285453993253742 1.08270137323222 0.365853658536585 17.4 17 4 increased bone trabecula number 0.0717864976705267 0.285453993253742 1.08270137323222 0.365853658536585 17.4 17 4 abnormal cranium morphology 0.00239164307814707 0.0236079847495668 1.0821627158326 0.365671641791045 17.4 17 4 decreased cardiac muscle contractility 0.00698375665867067 0.053452599041364 1.08131329454859 0.365384615384615 17.4 17 4 absent corpus luteum 0.0470766512357547 0.228049016453631 1.08131329454859 0.365384615384615 17.4 17 4 postnatal lethality, complete penetrance 5.33833170368697e-07 1.83160001557536e-05 1.08101841772979 0.365284974093264 17.4 17 4 abnormal skeleton morphology 0.00479343622221656 0.0397401040892883 1.08081841432225 0.365217391304348 17.4 17 4 retinal degeneration 0.00970898132863566 0.0692008339684275 1.07894199346405 0.364583333333333 17.4 17 4 polyuria 0.0199660265370893 0.117830346408089 1.07613954672778 0.363636363636364 17.4 17 4 abnormal rostral-caudal axis patterning 0.044490086381354 0.215939687558279 1.07613954672778 0.363636363636364 17.4 17 4 abnormal motor capabilities/coordination/movement 0.00299144618499559 0.028186448428699 1.07613954672778 0.363636363636364 17.4 17 4 hypertension 0.0676313542055929 0.272221672469923 1.07613954672778 0.363636363636364 17.4 17 4 abnormal gametogenesis 0.0676313542055929 0.272221672469923 1.07613954672778 0.363636363636364 17.4 17 4 omphalocele 0.0676313542055929 0.272221672469923 1.07613954672778 0.363636363636364 17.4 17 4 decreased systemic arterial blood pressure 0.104932528227182 0.37556970721759 1.07613954672778 0.363636363636364 17.4 17 4 single kidney 0.104932528227182 0.37556970721759 1.07613954672778 0.363636363636364 17.4 17 4 cardiovascular system phenotype 0.104932528227182 0.37556970721759 1.07613954672778 0.363636363636364 17.4 17 4 abnormal basisphenoid bone morphology 0.168676136288995 0.494349023653876 1.07613954672778 0.363636363636364 17.4 17 4 intracerebral hemorrhage 0.168676136288995 0.494349023653876 1.07613954672778 0.363636363636364 17.4 17 4 decreased cardiac output 0.168676136288995 0.494349023653876 1.07613954672778 0.363636363636364 17.4 17 4 abnormal female reproductive system physiology 0.168676136288995 0.494349023653876 1.07613954672778 0.363636363636364 17.4 17 4 decreased susceptibility to viral infection induced morbidity/mortality 0.168676136288995 0.494349023653876 1.07613954672778 0.363636363636364 17.4 17 4 abnormal sperm midpiece morphology 0.168676136288995 0.494349023653876 1.07613954672778 0.363636363636364 17.4 17 4 failure of palatal shelf elevation 0.168676136288995 0.494349023653876 1.07613954672778 0.363636363636364 17.4 17 4 abnormal sternum morphology 0.0280846807531031 0.154365797810263 1.07224049039906 0.36231884057971 17.4 17 4 abnormal epidermal layer morphology 0.0280846807531031 0.154365797810263 1.07224049039906 0.36231884057971 17.4 17 4 improved glucose tolerance 0.000415129939857496 0.00611027056447055 1.07202166580918 0.362244897959184 17.4 17 4 cochlear ganglion degeneration 0.0420375726546114 0.207066261343259 1.07150101419878 0.362068965517241 17.4 17 4 cleft secondary palate 0.0121940665697655 0.083849415279946 1.07041540020263 0.361702127659574 17.4 17 4 pulmonary hypoplasia 0.0637115032895235 0.258826972679877 1.07041540020263 0.361702127659574 17.4 17 4 abnormal digit morphology 0.0265858650303481 0.148946710051781 1.06866635543106 0.361111111111111 17.4 17 4 reduced long term depression 0.0983708532797746 0.36332219381357 1.06866635543106 0.361111111111111 17.4 17 4 abnormal limb bone morphology 0.0983708532797746 0.36332219381357 1.06866635543106 0.361111111111111 17.4 17 4 decreased oocyte number 0.0600181051099346 0.258826972679877 1.0653781512605 0.36 17.4 17 4 abnormal nest building behavior 0.156664766447532 0.483336421994481 1.0653781512605 0.36 17.4 17 4 increased anxiety-related response 0.00320855037538046 0.0297808546968615 1.06452653003648 0.359712230215827 17.4 17 4 decreased trabecular bone volume 0.0922483748369088 0.342233903664147 1.0623428858723 0.358974358974359 17.4 17 4 rib fusion 0.035439344080129 0.185006019725752 1.06007776244826 0.358208955223881 17.4 17 4 abnormal skeleton development 0.0225355905785089 0.129313221601017 1.05953245495729 0.358024691358025 17.4 17 4 alopecia 0.0144755331054931 0.0951331270803544 1.05914786967419 0.357894736842105 17.4 17 4 abnormal seminal vesicle morphology 0.0532690647458841 0.243802757231622 1.05692276910764 0.357142857142857 17.4 17 4 abnormal jaw morphology 0.145708982778566 0.472248983272551 1.05692276910764 0.357142857142857 17.4 17 4 failure of blastocyst to hatch from the zona pellucida 0.145708982778566 0.472248983272551 1.05692276910764 0.357142857142857 17.4 17 4 corneal vascularization 0.145708982778566 0.472248983272551 1.05692276910764 0.357142857142857 17.4 17 4 prolonged QRS complex duration 0.145708982778566 0.472248983272551 1.05692276910764 0.357142857142857 17.4 17 4 translucent skin 0.266001506371634 0.556129132657845 1.05692276910764 0.357142857142857 17.4 17 4 extended life span 0.266001506371634 0.556129132657845 1.05692276910764 0.357142857142857 17.4 17 4 abnormal fluid regulation 0.266001506371634 0.556129132657845 1.05692276910764 0.357142857142857 17.4 17 4 absent otoliths 0.266001506371634 0.556129132657845 1.05692276910764 0.357142857142857 17.4 17 4 decreased coping response 0.266001506371634 0.556129132657845 1.05692276910764 0.357142857142857 17.4 17 4 abnormal uterus development 0.266001506371634 0.556129132657845 1.05692276910764 0.357142857142857 17.4 17 4 abnormal positive T cell selection 0.266001506371634 0.556129132657845 1.05692276910764 0.357142857142857 17.4 17 4 abnormal glucose tolerance 0.266001506371634 0.556129132657845 1.05692276910764 0.357142857142857 17.4 17 4 increased pulmonary respiratory rate 0.266001506371634 0.556129132657845 1.05692276910764 0.357142857142857 17.4 17 4 increased lung compliance 0.266001506371634 0.556129132657845 1.05692276910764 0.357142857142857 17.4 17 4 pulmonary alveolar hemorrhage 0.266001506371634 0.556129132657845 1.05692276910764 0.357142857142857 17.4 17 4 abnormal renal tubule epithelial cell primary cilium morphology 0.266001506371634 0.556129132657845 1.05692276910764 0.357142857142857 17.4 17 4 abnormal retinal pigmentation 0.0201767782645011 0.118933023537788 1.05449306159245 0.35632183908046 17.4 17 4 abnormal spatial learning 0.00212965738585174 0.0216225418257396 1.05303225584712 0.355828220858896 17.4 17 4 abnormal rib morphology 0.0049431272735083 0.0403148494847603 1.05222533457828 0.355555555555556 17.4 17 4 increased circulating corticosterone level 0.0812080189328112 0.308907955015373 1.05222533457828 0.355555555555556 17.4 17 4 increased lung adenoma incidence 0.135687594332789 0.44557477346906 1.05010391253276 0.354838709677419 17.4 17 4 abnormal postnatal growth/weight/body size 0.135687594332789 0.44557477346906 1.05010391253276 0.354838709677419 17.4 17 4 abnormal podocyte morphology 0.135687594332789 0.44557477346906 1.05010391253276 0.354838709677419 17.4 17 4 oligodactyly 0.0762349283102497 0.29676742436893 1.04811507936508 0.354166666666667 17.4 17 4 abnormal kidney physiology 0.0762349283102497 0.29676742436893 1.04811507936508 0.354166666666667 17.4 17 4 small heart 0.0762349283102497 0.29676742436893 1.04811507936508 0.354166666666667 17.4 17 4 abnormal response/metabolism to endogenous compounds 0.0266535458810924 0.149157919863256 1.04661132745781 0.353658536585366 17.4 17 4 decreased susceptibility to injury 0.0420159608993938 0.207066261343259 1.04448838358873 0.352941176470588 17.4 17 4 abnormal cervical vertebrae morphology 0.0715919686122012 0.285453993253742 1.04448838358873 0.352941176470588 17.4 17 4 small lung 0.0715919686122012 0.285453993253742 1.04448838358873 0.352941176470588 17.4 17 4 increased kidney weight 0.0715919686122012 0.285453993253742 1.04448838358873 0.352941176470588 17.4 17 4 abnormal endoderm development 0.126496714771728 0.418153592019499 1.04448838358873 0.352941176470588 17.4 17 4 hydroureter 0.242558081440789 0.556129132657845 1.04448838358873 0.352941176470588 17.4 17 4 abnormal vagus nerve morphology 0.242558081440789 0.556129132657845 1.04448838358873 0.352941176470588 17.4 17 4 abnormal glutamate-mediated receptor currents 0.242558081440789 0.556129132657845 1.04448838358873 0.352941176470588 17.4 17 4 decreased growth hormone level 0.242558081440789 0.556129132657845 1.04448838358873 0.352941176470588 17.4 17 4 enhanced behavioral response to cocaine 0.242558081440789 0.556129132657845 1.04448838358873 0.352941176470588 17.4 17 4 increased hepatoma incidence 0.242558081440789 0.556129132657845 1.04448838358873 0.352941176470588 17.4 17 4 increased liver weight 0.0237888429700271 0.135256564315297 1.04251018589254 0.352272727272727 17.4 17 4 axon degeneration 0.067255253718773 0.271366494120759 1.04126465400975 0.351851851851852 17.4 17 4 abnormal pancreatic beta cell physiology 0.118047320330224 0.394385347064008 1.03978348095995 0.351351351351351 17.4 17 4 abnormal basioccipital bone morphology 0.222301311444388 0.556129132657845 1.03578431372549 0.35 17.4 17 4 abnormal cell proliferation 0.222301311444388 0.556129132657845 1.03578431372549 0.35 17.4 17 4 increased urine glucose level 0.222301311444388 0.556129132657845 1.03578431372549 0.35 17.4 17 4 decreased paired-pulse facilitation 0.222301311444388 0.556129132657845 1.03578431372549 0.35 17.4 17 4 abnormal hyoid bone morphology 0.222301311444388 0.556129132657845 1.03578431372549 0.35 17.4 17 4 kidney atrophy 0.222301311444388 0.556129132657845 1.03578431372549 0.35 17.4 17 4 abnormal sperm mitochondrial sheath morphology 0.222301311444388 0.556129132657845 1.03578431372549 0.35 17.4 17 4 decreased muscle cell glucose uptake 0.222301311444388 0.556129132657845 1.03578431372549 0.35 17.4 17 4 delayed endochondral bone ossification 0.103077036815062 0.37556970721759 1.03234316982607 0.348837209302326 17.4 17 4 abnormal tail morphology 0.0525519763929824 0.240742249129915 1.03130039894746 0.348484848484849 17.4 17 4 decreased rib number 0.027886489935863 0.154365797810263 1.03079658829824 0.348314606741573 17.4 17 4 abnormal cranial nerve morphology 0.204522257602777 0.556129132657845 1.0293508707831 0.347826086956522 17.4 17 4 abnormal sacral vertebrae morphology 0.204522257602777 0.556129132657845 1.0293508707831 0.347826086956522 17.4 17 4 dilated heart 0.204522257602777 0.556129132657845 1.0293508707831 0.347826086956522 17.4 17 4 abnormal chondrocyte physiology 0.204522257602777 0.556129132657845 1.0293508707831 0.347826086956522 17.4 17 4 abnormal basicranium morphology 0.204522257602777 0.556129132657845 1.0293508707831 0.347826086956522 17.4 17 4 abnormal vertebral artery topology 0.204522257602777 0.556129132657845 1.0293508707831 0.347826086956522 17.4 17 4 impaired righting response 0.0248359487035362 0.141048909589147 1.02799646174259 0.347368421052632 17.4 17 4 abnormal heart left ventricle morphology 0.0465363523711372 0.225651416224569 1.0275638032991 0.347222222222222 17.4 17 4 microphthalmia 0.00599422286986417 0.0474105862918509 1.02514600611486 0.34640522875817 17.4 17 4 eyelids open at birth 0.0845706660467906 0.315396599387394 1.02440206851972 0.346153846153846 17.4 17 4 decreased kidney weight 0.0845706660467906 0.315396599387394 1.02440206851972 0.346153846153846 17.4 17 4 abnormal brain wave pattern 0.0845706660467906 0.315396599387394 1.02440206851972 0.346153846153846 17.4 17 4 increased susceptibility to injury 0.0845706660467906 0.315396599387394 1.02440206851972 0.346153846153846 17.4 17 4 increased percent body fat/body weight 0.0845706660467906 0.315396599387394 1.02440206851972 0.346153846153846 17.4 17 4 abnormal stomach morphology 0.18873982039603 0.533511708221733 1.02440206851972 0.346153846153846 17.4 17 4 no spontaneous movement 0.18873982039603 0.533511708221733 1.02440206851972 0.346153846153846 17.4 17 4 abnormal nervous system electrophysiology 0.0366042055797077 0.189496277584855 1.02169201013739 0.345238095238095 17.4 17 4 decreased granulocyte number 0.17460879117832 0.496671661584988 1.02047715637979 0.344827586206897 17.4 17 4 stomach inflammation 0.17460879117832 0.496671661584988 1.02047715637979 0.344827586206897 17.4 17 4 short sternum 0.17460879117832 0.496671661584988 1.02047715637979 0.344827586206897 17.4 17 4 cyanosis 0.00294945388583141 0.0281459316983279 1.01728816526611 0.34375 17.4 17 4 decreased eosinophil cell number 0.065482029582946 0.264641021263328 1.01728816526611 0.34375 17.4 17 4 kidney cortex cysts 0.16187085132961 0.489232254603493 1.01728816526611 0.34375 17.4 17 4 failure of primitive streak formation 0.16187085132961 0.489232254603493 1.01728816526611 0.34375 17.4 17 4 increased dopamine level 0.16187085132961 0.489232254603493 1.01728816526611 0.34375 17.4 17 4 neonatal lethality 0.16187085132961 0.489232254603493 1.01728816526611 0.34375 17.4 17 4 thick pulmonary interalveolar septum 0.150326293158662 0.483336421994481 1.01464585834334 0.342857142857143 17.4 17 4 abnormal artery morphology 0.150326293158662 0.483336421994481 1.01464585834334 0.342857142857143 17.4 17 4 abnormal fertility/fecundity 0.0543049554710899 0.247179463374815 1.01348758681555 0.342465753424658 17.4 17 4 abnormal axial skeleton morphology 0.0510585888081899 0.239468002514514 1.01242075777679 0.342105263157895 17.4 17 4 persistence of hyaloid vascular system 0.139816656940622 0.457924863910202 1.01242075777679 0.342105263157895 17.4 17 4 abnormal retinal outer nuclear layer morphology 0.139816656940622 0.457924863910202 1.01242075777679 0.342105263157895 17.4 17 4 increased tumor growth/size 0.130213528316698 0.4290147704474 1.01052128168341 0.341463414634146 17.4 17 4 small kidney 0.0400277727821637 0.199614633158004 1.0088808250573 0.340909090909091 17.4 17 4 renal interstitial fibrosis 0.12141101057858 0.402411577367379 1.0088808250573 0.340909090909091 17.4 17 4 increased thermal nociceptive threshold 0.0376913099355747 0.194516874408178 1.00814171822575 0.340659340659341 17.4 17 4 increased body length 0.105866900838595 0.37556970721759 1.00619047619048 0.34 17.4 17 4 abnormal pancreatic islet morphology 0.0989859622668546 0.365322820680713 1.00507372760425 0.339622641509434 17.4 17 4 decreased liver weight 0.0670562300349632 0.27078307177268 1.00035507160611 0.338028169014085 17.4 17 4 abnormal phalanx morphology 0.13186327348972 0.434162664203415 0.986461251167134 0.333333333333333 17.4 17 4 abnormal body weight 0.243040038945673 0.556129132657845 0.986461251167134 0.333333333333333 17.4 17 4 blindness 0.243040038945673 0.556129132657845 0.986461251167134 0.333333333333333 17.4 17 4 abnormal sensory capabilities/reflexes/nociception 0.243040038945673 0.556129132657845 0.986461251167134 0.333333333333333 17.4 17 4 abnormal retinal ganglion layer morphology 0.243040038945673 0.556129132657845 0.986461251167134 0.333333333333333 17.4 17 4 decreased fatty acid level 0.243040038945673 0.556129132657845 0.986461251167134 0.333333333333333 17.4 17 4 increased food intake 0.0600473496546101 0.258826972679877 0.986461251167134 0.333333333333333 17.4 17 4 cochlear outer hair cell degeneration 0.0773161688668768 0.300741157242152 0.986461251167134 0.333333333333333 17.4 17 4 hyperkeratosis 0.0824584644468376 0.312437822256677 0.986461251167134 0.333333333333333 17.4 17 4 abnormal kidney development 0.100383819293992 0.369932963694525 0.986461251167134 0.333333333333333 17.4 17 4 abnormal long bone epiphyseal plate morphology 0.100383819293992 0.369932963694525 0.986461251167134 0.333333333333333 17.4 17 4 irregular heartbeat 0.141512506401465 0.462869637966658 0.986461251167134 0.333333333333333 17.4 17 4 increased vascular permeability 0.16360079799248 0.490901067558858 0.986461251167134 0.333333333333333 17.4 17 4 abnormal epidermis stratum granulosum morphology 0.176304013098107 0.500920882446078 0.986461251167134 0.333333333333333 17.4 17 4 abnormal scapula morphology 0.265461919978758 0.556129132657845 0.986461251167134 0.333333333333333 17.4 17 4 abnormal embryonic/fetal subventricular zone morphology 0.265461919978758 0.556129132657845 0.986461251167134 0.333333333333333 17.4 17 4 decreased cochlear outer hair cell number 0.265461919978758 0.556129132657845 0.986461251167134 0.333333333333333 17.4 17 4 abnormal bile salt homeostasis 0.265461919978758 0.556129132657845 0.986461251167134 0.333333333333333 17.4 17 4 complete atrioventricular septal defect 0.265461919978758 0.556129132657845 0.986461251167134 0.333333333333333 17.4 17 4 decreased vocalization 0.265461919978758 0.556129132657845 0.986461251167134 0.333333333333333 17.4 17 4 abnormal heart shape 0.291393727189193 0.604407606943398 0.986461251167134 0.333333333333333 17.4 17 4 abnormal radius morphology 0.291393727189193 0.604407606943398 0.986461251167134 0.333333333333333 17.4 17 4 abnormal mammary gland morphology 0.291393727189193 0.604407606943398 0.986461251167134 0.333333333333333 17.4 17 4 blepharoptosis 0.291393727189193 0.604407606943398 0.986461251167134 0.333333333333333 17.4 17 4 eye inflammation 0.291393727189193 0.604407606943398 0.986461251167134 0.333333333333333 17.4 17 4 abnormal thyroid cartilage morphology 0.291393727189193 0.604407606943398 0.986461251167134 0.333333333333333 17.4 17 4 abnormal glycogen homeostasis 0.291393727189193 0.604407606943398 0.986461251167134 0.333333333333333 17.4 17 4 atrioventricular block 0.291393727189193 0.604407606943398 0.986461251167134 0.333333333333333 17.4 17 4 decreased fluid intake 0.291393727189193 0.604407606943398 0.986461251167134 0.333333333333333 17.4 17 4 abnormal fontanelle morphology 0.321990100193693 0.654776927840926 0.986461251167134 0.333333333333333 17.4 17 4 absent incisors 0.321990100193693 0.654776927840926 0.986461251167134 0.333333333333333 17.4 17 4 decreased chondrocyte number 0.321990100193693 0.654776927840926 0.986461251167134 0.333333333333333 17.4 17 4 placental labyrinth hypoplasia 0.321990100193693 0.654776927840926 0.986461251167134 0.333333333333333 17.4 17 4 abnormal respiratory system morphology 0.321990100193693 0.654776927840926 0.986461251167134 0.333333333333333 17.4 17 4 abnormal glial cell morphology 0.321990100193693 0.654776927840926 0.986461251167134 0.333333333333333 17.4 17 4 abnormal zygomatic bone morphology 0.321990100193693 0.654776927840926 0.986461251167134 0.333333333333333 17.4 17 4 abnormal cerebral aqueduct morphology 0.321990100193693 0.654776927840926 0.986461251167134 0.333333333333333 17.4 17 4 herniated liver 0.321990100193693 0.654776927840926 0.986461251167134 0.333333333333333 17.4 17 4 abnormal cochlea morphology 0.114851316540896 0.394385347064008 0.986461251167133 0.333333333333333 17.4 17 4 abnormal small intestine morphology 0.114851316540896 0.394385347064008 0.986461251167133 0.333333333333333 17.4 17 4 cochlear inner hair cell degeneration 0.123004366951792 0.40715018335673 0.986461251167133 0.333333333333333 17.4 17 4 dextrocardia 0.190340012880824 0.537119435100453 0.986461251167133 0.333333333333333 17.4 17 4 abnormal epidermis stratum basale morphology 0.190340012880824 0.537119435100453 0.986461251167133 0.333333333333333 17.4 17 4 dilated heart atrium 0.190340012880824 0.537119435100453 0.986461251167133 0.333333333333333 17.4 17 4 abnormal fetal cardiomyocyte proliferation 0.223372303780867 0.556129132657845 0.986461251167133 0.333333333333333 17.4 17 4 decreased bone ossification 0.223372303780867 0.556129132657845 0.986461251167133 0.333333333333333 17.4 17 4 abnormal facial morphology 0.107331901825027 0.376835717416731 0.986461251167133 0.333333333333333 17.4 17 4 abnormal excitatory postsynaptic potential 0.0731229953586724 0.285995992067134 0.974431235908998 0.329268292682927 17.4 17 4 decreased food intake 0.0779138618773697 0.302829267843683 0.973974399886537 0.329113924050633 17.4 17 4 abnormal trabecular bone morphology 0.0398294848679958 0.199147424339979 0.969882070475249 0.327731092436975 17.4 17 4 abnormal enzyme/coenzyme level 0.123403852258273 0.408200907569751 0.969453298560804 0.327586206896552 17.4 17 4 increased circulating calcium level 0.132161047381239 0.43485529809634 0.968525592055004 0.327272727272727 17.4 17 4 abnormal female meiosis 0.141672164534222 0.463087397212716 0.967490842490842 0.326923076923077 17.4 17 4 organ of Corti degeneration 0.152025679889172 0.483336421994481 0.966329388898416 0.326530612244898 17.4 17 4 abnormal epidermis stratum corneum morphology 0.152025679889172 0.483336421994481 0.966329388898416 0.326530612244898 17.4 17 4 abnormal blood circulation 0.175694919101918 0.499475555732596 0.963520291837665 0.325581395348837 17.4 17 4 decreased anxiety-related response 0.0424086219710965 0.208661540934127 0.962401220650862 0.32520325203252 17.4 17 4 decreased width of hypertrophic chondrocyte zone 0.204267225626691 0.556129132657845 0.959800136270724 0.324324324324324 17.4 17 4 abnormal hair follicle development 0.204267225626691 0.556129132657845 0.959800136270724 0.324324324324324 17.4 17 4 abnormal humerus morphology 0.204267225626691 0.556129132657845 0.959800136270724 0.324324324324324 17.4 17 4 corneal opacity 0.107703358095438 0.377873206293938 0.958673610289186 0.323943661971831 17.4 17 4 abnormal retinal photoreceptor morphology 0.220873764150391 0.556129132657845 0.957447684956335 0.323529411764706 17.4 17 4 decreased susceptibility to bacterial infection induced morbidity/mortality 0.239383449601922 0.556129132657845 0.954639920484323 0.32258064516129 17.4 17 4 abnormal intestine physiology 0.239383449601922 0.556129132657845 0.954639920484323 0.32258064516129 17.4 17 4 abnormal thoracic vertebrae morphology 0.140825327343072 0.460925002323541 0.95302188672079 0.322033898305085 17.4 17 4 increased circulating luteinizing hormone level 0.260160192676693 0.556129132657845 0.951230492196879 0.321428571428571 17.4 17 4 abnormal ovulation 0.260160192676693 0.556129132657845 0.951230492196879 0.321428571428571 17.4 17 4 abnormal respiration 0.260160192676693 0.556129132657845 0.951230492196879 0.321428571428571 17.4 17 4 abnormal hormone level 0.260160192676693 0.556129132657845 0.951230492196879 0.321428571428571 17.4 17 4 absent gastric milk in neonates 0.107051556200531 0.376116872950314 0.948520433814552 0.320512820512821 17.4 17 4 decreased placenta weight 0.283687226003621 0.591262651599503 0.947002801120448 0.32 17.4 17 4 increased liver glycogen level 0.283687226003621 0.591262651599503 0.947002801120448 0.32 17.4 17 4 abnormal neuromuscular synapse morphology 0.121966732631293 0.403984350759444 0.94535869903517 0.319444444444444 17.4 17 4 abnormal tibia morphology 0.186765343458344 0.52853104875157 0.944484176649383 0.319148936170213 17.4 17 4 small ovary 0.093437379417987 0.346386708349095 0.943100317049897 0.318681318681319 17.4 17 4 cochlear hair cell degeneration 0.201027409746142 0.556129132657845 0.941622103386809 0.318181818181818 17.4 17 4 increased body size 0.310628619033981 0.635957769421422 0.941622103386809 0.318181818181818 17.4 17 4 abnormal tail movements 0.310628619033981 0.635957769421422 0.941622103386809 0.318181818181818 17.4 17 4 testis hypoplasia 0.310628619033981 0.635957769421422 0.941622103386809 0.318181818181818 17.4 17 4 abnormal channel response 0.310628619033981 0.635957769421422 0.941622103386809 0.318181818181818 17.4 17 4 abnormal retinal layer morphology 0.310628619033981 0.635957769421422 0.941622103386809 0.318181818181818 17.4 17 4 abnormal limb posture 0.310628619033981 0.635957769421422 0.941622103386809 0.318181818181818 17.4 17 4 abnormal basement membrane morphology 0.310628619033981 0.635957769421422 0.941622103386809 0.318181818181818 17.4 17 4 circling 0.106031519099218 0.37556970721759 0.940039545229857 0.317647058823529 17.4 17 4 abnormal cholesterol homeostasis 0.216706705361519 0.556129132657845 0.93834119013459 0.317073170731707 17.4 17 4 abnormal eye physiology 0.159566513999962 0.484346191061508 0.937138188608777 0.316666666666667 17.4 17 4 abnormal compact bone morphology 0.234013641943337 0.556129132657845 0.934542237947811 0.315789473684211 17.4 17 4 impaired branching involved in ureteric bud morphogenesis 0.234013641943337 0.556129132657845 0.934542237947811 0.315789473684211 17.4 17 4 decreased threshold for auditory brainstem response 0.234013641943337 0.556129132657845 0.934542237947811 0.315789473684211 17.4 17 4 abnormal nail morphology 0.341937154731529 0.679367949197028 0.934542237947811 0.315789473684211 17.4 17 4 shiny skin 0.341937154731529 0.679367949197028 0.934542237947811 0.315789473684211 17.4 17 4 abnormal ear morphology 0.341937154731529 0.679367949197028 0.934542237947811 0.315789473684211 17.4 17 4 decreased germ cell number 0.341937154731529 0.679367949197028 0.934542237947811 0.315789473684211 17.4 17 4 abnormal metatarsal bone morphology 0.341937154731529 0.679367949197028 0.934542237947811 0.315789473684211 17.4 17 4 abnormal response to novelty 0.341937154731529 0.679367949197028 0.934542237947811 0.315789473684211 17.4 17 4 decreased eye pigmentation 0.341937154731529 0.679367949197028 0.934542237947811 0.315789473684211 17.4 17 4 eyelids fail to open 0.341937154731529 0.679367949197028 0.934542237947811 0.315789473684211 17.4 17 4 thin interventricular septum 0.341937154731529 0.679367949197028 0.934542237947811 0.315789473684211 17.4 17 4 seizures 0.0761141411071784 0.29676742436893 0.934542237947811 0.315789473684211 17.4 17 4 thick epidermis 0.146697044112706 0.475141793268692 0.930092036814726 0.314285714285714 17.4 17 4 impaired adaptive thermogenesis 0.253208021688267 0.556129132657845 0.930092036814726 0.314285714285714 17.4 17 4 decreased bone mineralization 0.253208021688267 0.556129132657845 0.930092036814726 0.314285714285714 17.4 17 4 abnormal femur morphology 0.156814517609635 0.483336421994481 0.92756804214223 0.313432835820896 17.4 17 4 abnormal cardiovascular system morphology 0.211720829807718 0.556129132657845 0.924807422969188 0.3125 17.4 17 4 increased circulating follicle stimulating hormone level 0.274616448816609 0.573077530563184 0.924807422969188 0.3125 17.4 17 4 abnormal diaphragm morphology 0.274616448816609 0.573077530563184 0.924807422969188 0.3125 17.4 17 4 abnormal tympanic ring morphology 0.379058090952942 0.718131760278327 0.924807422969188 0.3125 17.4 17 4 abnormal extraembryonic endoderm formation 0.379058090952942 0.718131760278327 0.924807422969188 0.3125 17.4 17 4 impaired muscle relaxation 0.379058090952942 0.718131760278327 0.924807422969188 0.3125 17.4 17 4 decreased aggression towards mice 0.379058090952942 0.718131760278327 0.924807422969188 0.3125 17.4 17 4 small epididymis 0.379058090952942 0.718131760278327 0.924807422969188 0.3125 17.4 17 4 abnormal wound healing 0.379058090952942 0.718131760278327 0.924807422969188 0.3125 17.4 17 4 decreased circulating prolactin level 0.379058090952942 0.718131760278327 0.924807422969188 0.3125 17.4 17 4 loose skin 0.379058090952942 0.718131760278327 0.924807422969188 0.3125 17.4 17 4 impaired behavioral response to addictive substance 0.379058090952942 0.718131760278327 0.924807422969188 0.3125 17.4 17 4 abnormal autopod morphology 0.227905108030835 0.556129132657845 0.920697167755991 0.311111111111111 17.4 17 4 small placenta 0.227905108030835 0.556129132657845 0.920697167755991 0.311111111111111 17.4 17 4 lethality at weaning, complete penetrance 0.227905108030835 0.556129132657845 0.920697167755991 0.311111111111111 17.4 17 4 aphagia 0.298658323350961 0.613470338014464 0.918429440741814 0.310344827586207 17.4 17 4 abnormal outer ear morphology 0.298658323350961 0.613470338014464 0.918429440741814 0.310344827586207 17.4 17 4 increased retinal apoptosis 0.298658323350961 0.613470338014464 0.918429440741814 0.310344827586207 17.4 17 4 atelectasis 0.164204413344948 0.492415284141721 0.916992148972265 0.309859154929577 17.4 17 4 abnormal hair growth 0.221509693554087 0.556129132657845 0.910579616461969 0.307692307692308 17.4 17 4 decreased body temperature 0.221509693554087 0.556129132657845 0.910579616461969 0.307692307692308 17.4 17 4 abnormal ureter morphology 0.325886072940329 0.654776927840926 0.910579616461969 0.307692307692308 17.4 17 4 thick skin 0.325886072940329 0.654776927840926 0.910579616461969 0.307692307692308 17.4 17 4 abnormal neurocranium morphology 0.171230947803039 0.494349023653876 0.907544351073763 0.306666666666667 17.4 17 4 head tilt 0.287045785467937 0.597761734074085 0.904256146903206 0.305555555555556 17.4 17 4 abnormal colon morphology 0.215055770165949 0.556129132657845 0.902862840051275 0.305084745762712 17.4 17 4 abnormal food intake 0.195238770401677 0.549967129771329 0.900682011935209 0.304347826086957 17.4 17 4 abnormal innervation pattern to muscle 0.357050152160133 0.706547041298818 0.900682011935209 0.304347826086957 17.4 17 4 bidirectional circling 0.357050152160133 0.706547041298818 0.900682011935209 0.304347826086957 17.4 17 4 hypotension 0.357050152160133 0.706547041298818 0.900682011935209 0.304347826086957 17.4 17 4 increased susceptibility to age related obesity 0.357050152160133 0.706547041298818 0.900682011935209 0.304347826086957 17.4 17 4 abnormal Wolffian duct morphology 0.357050152160133 0.706547041298818 0.900682011935209 0.304347826086957 17.4 17 4 abnormal lens development 0.357050152160133 0.706547041298818 0.900682011935209 0.304347826086957 17.4 17 4 short mandible 0.23051501240303 0.556129132657845 0.898384353741497 0.303571428571429 17.4 17 4 abnormal skin morphology 0.208664714941537 0.556129132657845 0.896782955606485 0.303030303030303 17.4 17 4 abnormal aorta morphology 0.311258377484342 0.636723037822617 0.896782955606485 0.303030303030303 17.4 17 4 abnormal middle ear ossicle morphology 0.311258377484342 0.636723037822617 0.896782955606485 0.303030303030303 17.4 17 4 deafness 0.149019688548497 0.482037028952388 0.896782955606485 0.303030303030303 17.4 17 4 abnormal CNS synaptic transmission 0.149019688548497 0.482037028952388 0.896782955606485 0.303030303030303 17.4 17 4 abnormal intestinal mucosa morphology 0.276021057677834 0.575767195785 0.894697413849261 0.302325581395349 17.4 17 4 abnormal estrous cycle 0.338397673197665 0.675573203915884 0.88781512605042 0.3 17.4 17 4 dehydration 0.216042367382665 0.556129132657845 0.88781512605042 0.3 17.4 17 4 impaired ovarian folliculogenesis 0.297890896305788 0.612652835519344 0.88781512605042 0.3 17.4 17 4 abnormal pericardium morphology 0.393209658997447 0.741834680892037 0.88781512605042 0.3 17.4 17 4 abnormal vascular regression 0.393209658997447 0.741834680892037 0.88781512605042 0.3 17.4 17 4 abnormal hearing physiology 0.393209658997447 0.741834680892037 0.88781512605042 0.3 17.4 17 4 abnormal trachea morphology 0.393209658997447 0.741834680892037 0.88781512605042 0.3 17.4 17 4 abnormal lens epithelium morphology 0.393209658997447 0.741834680892037 0.88781512605042 0.3 17.4 17 4 absent placental labyrinth 0.393209658997447 0.741834680892037 0.88781512605042 0.3 17.4 17 4 abnormal male reproductive system physiology 0.393209658997447 0.741834680892037 0.88781512605042 0.3 17.4 17 4 abnormal heart right ventricle morphology 0.393209658997447 0.741834680892037 0.88781512605042 0.3 17.4 17 4 abnormal postnatal subventricular zone morphology 0.393209658997447 0.741834680892037 0.88781512605042 0.3 17.4 17 4 nuclear cataracts 0.393209658997447 0.741834680892037 0.88781512605042 0.3 17.4 17 4 maternal effect 0.230728628699794 0.556129132657845 0.883398135373552 0.298507462686567 17.4 17 4 abnormal innervation 0.285598288403136 0.5949964341732 0.881518564872758 0.297872340425532 17.4 17 4 decreased circulating chloride level 0.322067483862311 0.654776927840926 0.879816791581497 0.297297297297297 17.4 17 4 abnormal long bone epiphyseal plate proliferative zone 0.274223940032444 0.572738917574058 0.876854445481897 0.296296296296296 17.4 17 4 abnormal osteoblast physiology 0.274223940032444 0.572738917574058 0.876854445481897 0.296296296296296 17.4 17 4 thin epidermis 0.369049765217997 0.709403590706503 0.876854445481897 0.296296296296296 17.4 17 4 abnormal type II pneumocyte morphology 0.369049765217997 0.709403590706503 0.876854445481897 0.296296296296296 17.4 17 4 short femur 0.208530392439809 0.556129132657845 0.874363381716323 0.295454545454545 17.4 17 4 short maxilla 0.348918633040156 0.692133253339224 0.870406986323941 0.294117647058824 17.4 17 4 overexpanded pulmonary alveoli 0.348918633040156 0.692133253339224 0.870406986323941 0.294117647058824 17.4 17 4 thin skin 0.348918633040156 0.692133253339224 0.870406986323941 0.294117647058824 17.4 17 4 distended urinary bladder 0.435933094916339 0.744303547239377 0.870406986323941 0.294117647058824 17.4 17 4 increased incidence of corneal inflammation 0.435933094916339 0.744303547239377 0.870406986323941 0.294117647058824 17.4 17 4 abnormal cranial suture morphology 0.435933094916339 0.744303547239377 0.870406986323941 0.294117647058824 17.4 17 4 nephrocalcinosis 0.435933094916339 0.744303547239377 0.870406986323941 0.294117647058824 17.4 17 4 abnormal tarsal bone morphology 0.435933094916339 0.744303547239377 0.870406986323941 0.294117647058824 17.4 17 4 abnormal ductus venosus valve morphology 0.435933094916339 0.744303547239377 0.870406986323941 0.294117647058824 17.4 17 4 abnormal urine homeostasis 0.219658083866724 0.556129132657845 0.863153594771242 0.291666666666667 17.4 17 4 abnormal malleus morphology 0.403995492895499 0.744303547239377 0.863153594771242 0.291666666666667 17.4 17 4 increased stereotypic behavior 0.403995492895499 0.744303547239377 0.863153594771242 0.291666666666667 17.4 17 4 abnormal impulse conducting system conduction 0.403995492895499 0.744303547239377 0.863153594771242 0.291666666666667 17.4 17 4 hypopigmentation 0.403995492895499 0.744303547239377 0.863153594771242 0.291666666666667 17.4 17 4 abnormal truncus arteriosus septation 0.403995492895499 0.744303547239377 0.863153594771242 0.291666666666667 17.4 17 4 abnormal eyelid morphology 0.378903491941377 0.718131760278327 0.859175928435891 0.290322580645161 17.4 17 4 abnormal nose morphology 0.378903491941377 0.718131760278327 0.859175928435891 0.290322580645161 17.4 17 4 decreased neuronal precursor cell number 0.378903491941377 0.718131760278327 0.859175928435891 0.290322580645161 17.4 17 4 hyporesponsive to tactile stimuli 0.357941271310782 0.706547041298818 0.856663718118826 0.289473684210526 17.4 17 4 altered response to myocardial infarction 0.339793246939709 0.677543648707437 0.854933084344849 0.288888888888889 17.4 17 4 abnormal ectoderm development 0.339793246939709 0.677543648707437 0.854933084344849 0.288888888888889 17.4 17 4 decreased osteoclast cell number 0.339793246939709 0.677543648707437 0.854933084344849 0.288888888888889 17.4 17 4 abnormal neuron differentiation 0.239213415576666 0.556129132657845 0.845538215286115 0.285714285714286 17.4 17 4 abnormal stria vascularis morphology 0.412605594234519 0.744303547239377 0.845538215286115 0.285714285714286 17.4 17 4 rib bifurcation 0.412605594234519 0.744303547239377 0.845538215286115 0.285714285714286 17.4 17 4 absent corpus callosum 0.412605594234519 0.744303547239377 0.845538215286115 0.285714285714286 17.4 17 4 abnormal cartilage morphology 0.365802136677088 0.709403590706503 0.845538215286115 0.285714285714286 17.4 17 4 trunk curl 0.444308754604923 0.74879270127354 0.845538215286115 0.285714285714286 17.4 17 4 dry skin 0.444308754604923 0.74879270127354 0.845538215286115 0.285714285714286 17.4 17 4 abnormal action potential 0.302269236862894 0.620631223026371 0.845538215286114 0.285714285714286 17.4 17 4 abnormal excitatory postsynaptic currents 0.3134916238438 0.641027878595523 0.834697981756805 0.282051282051282 17.4 17 4 small lens 0.394332819618477 0.743389836150786 0.834697981756805 0.282051282051282 17.4 17 4 abnormal lens fiber morphology 0.394332819618477 0.743389836150786 0.834697981756805 0.282051282051282 17.4 17 4 abnormal lymphatic vessel morphology 0.419711465338027 0.744303547239377 0.832326680672269 0.28125 17.4 17 4 abnormal long term potentiation 0.419711465338027 0.744303547239377 0.832326680672269 0.28125 17.4 17 4 bradykinesia 0.419711465338027 0.744303547239377 0.832326680672269 0.28125 17.4 17 4 abnormal auditory brainstem response waveform shape 0.419711465338027 0.744303547239377 0.832326680672269 0.28125 17.4 17 4 abnormal axon extension 0.378930472891827 0.718131760278327 0.828627450980392 0.28 17.4 17 4 abnormal thyroid gland morphology 0.450782041131229 0.758930847589801 0.828627450980392 0.28 17.4 17 4 abnormal feces composition 0.450782041131229 0.758930847589801 0.828627450980392 0.28 17.4 17 4 abnormal vertebrae development 0.450782041131229 0.758930847589801 0.828627450980392 0.28 17.4 17 4 polyphagia 0.38450453119575 0.728172836961879 0.822051042639278 0.277777777777778 17.4 17 4 narrow eye opening 0.425724836085901 0.744303547239377 0.822051042639278 0.277777777777778 17.4 17 4 abnormal stomach glandular epithelium morphology 0.49152515942678 0.80017593853018 0.822051042639278 0.277777777777778 17.4 17 4 absent spleen 0.49152515942678 0.80017593853018 0.822051042639278 0.277777777777778 17.4 17 4 abnormal retinal rod cell morphology 0.49152515942678 0.80017593853018 0.822051042639278 0.277777777777778 17.4 17 4 short limbs 0.346656615510341 0.688469725414748 0.816381725103835 0.275862068965517 17.4 17 4 abnormal middle ear morphology 0.456014078380636 0.766701601873492 0.816381725103835 0.275862068965517 17.4 17 4 focal hair loss 0.456014078380636 0.766701601873492 0.816381725103835 0.275862068965517 17.4 17 4 abnormal spinal nerve morphology 0.456014078380636 0.766701601873492 0.816381725103835 0.275862068965517 17.4 17 4 decreased retinal photoreceptor cell number 0.456014078380636 0.766701601873492 0.816381725103835 0.275862068965517 17.4 17 4 decreased circulating phosphate level 0.430914238806049 0.744303547239377 0.813830532212885 0.275 17.4 17 4 abnormal skin pigmentation 0.430914238806049 0.744303547239377 0.813830532212885 0.275 17.4 17 4 embryonic lethality, incomplete penetrance 0.435463388715379 0.744303547239377 0.807104660045836 0.272727272727273 17.4 17 4 diarrhea 0.460381373283158 0.773782882460713 0.807104660045836 0.272727272727273 17.4 17 4 abnormal enterocyte morphology 0.494438805444026 0.802032297712431 0.807104660045836 0.272727272727273 17.4 17 4 intestinal ulcer 0.494438805444026 0.802032297712431 0.807104660045836 0.272727272727273 17.4 17 4 abnormal facial nerve morphology 0.494438805444026 0.802032297712431 0.807104660045836 0.272727272727273 17.4 17 4 decreased airway responsiveness 0.494438805444026 0.802032297712431 0.807104660045836 0.272727272727273 17.4 17 4 abnormal chorion morphology 0.494438805444026 0.802032297712431 0.807104660045836 0.272727272727273 17.4 17 4 abnormal tracheal cartilage morphology 0.494438805444026 0.802032297712431 0.807104660045836 0.272727272727273 17.4 17 4 abnormal cochlear sensory epithelium morphology 0.494438805444026 0.802032297712431 0.807104660045836 0.272727272727273 17.4 17 4 abnormal retinal outer plexiform layer morphology 0.494438805444026 0.802032297712431 0.807104660045836 0.272727272727273 17.4 17 4 abnormal blood-brain barrier function 0.494438805444026 0.802032297712431 0.807104660045836 0.272727272727273 17.4 17 4 decreased circulating estradiol level 0.494438805444026 0.802032297712431 0.807104660045836 0.272727272727273 17.4 17 4 abnormal temporal bone morphology 0.494438805444026 0.802032297712431 0.807104660045836 0.272727272727273 17.4 17 4 impaired fertilization 0.402363831532454 0.744303547239377 0.803261304521809 0.271428571428571 17.4 17 4 syndactyly 0.419452200097276 0.744303547239377 0.802544746712244 0.271186440677966 17.4 17 4 abnormal hair follicle morphology 0.423147063538474 0.744303547239377 0.798563869992441 0.26984126984127 17.4 17 4 abnormal kidney cortex morphology 0.49679634520156 0.805331318793667 0.796757164404223 0.269230769230769 17.4 17 4 abnormal tectorial membrane morphology 0.49679634520156 0.805331318793667 0.796757164404223 0.269230769230769 17.4 17 4 abnormal heart tube morphology 0.498783680265352 0.807763284283896 0.789169000933707 0.266666666666667 17.4 17 4 delayed eyelid opening 0.498783680265352 0.807763284283896 0.789169000933707 0.266666666666667 17.4 17 4 abnormal lactation 0.498783680265352 0.807763284283896 0.789169000933707 0.266666666666667 17.4 17 4 abnormal vision 0.500507959770639 0.810028334371805 0.783366287691547 0.264705882352941 17.4 17 4 decreased osteoblast cell number 0.500507959770639 0.810028334371805 0.783366287691547 0.264705882352941 17.4 17 4 abnormal coat/ hair morphology 0.475169513350994 0.782252921549039 0.78172401035886 0.264150943396226 17.4 17 4 short vibrissae 0.544949446817941 0.867312381598552 0.778785198289842 0.263157894736842 17.4 17 4 unresponsive to tactile stimuli 0.544949446817941 0.867312381598552 0.778785198289842 0.263157894736842 17.4 17 4 osteoarthritis 0.544949446817941 0.867312381598552 0.778785198289842 0.263157894736842 17.4 17 4 abnormal photoreceptor inner segment morphology 0.544949446817941 0.867312381598552 0.778785198289842 0.263157894736842 17.4 17 4 decreased liver regeneration 0.544949446817941 0.867312381598552 0.778785198289842 0.263157894736842 17.4 17 4 abnormal behavioral response to xenobiotic 0.544949446817941 0.867312381598552 0.778785198289842 0.263157894736842 17.4 17 4 decreased liver glycogen level 0.544949446817941 0.867312381598552 0.778785198289842 0.263157894736842 17.4 17 4 right-sided stomach 0.544949446817941 0.867312381598552 0.778785198289842 0.263157894736842 17.4 17 4 abnormal forelimb morphology 0.504668650011832 0.81649643375898 0.772013153087322 0.260869565217391 17.4 17 4 abnormal regulatory T cell physiology 0.542928918367753 0.867312381598552 0.772013153087322 0.260869565217391 17.4 17 4 abnormal palatal shelf fusion at midline 0.542928918367753 0.867312381598552 0.772013153087322 0.260869565217391 17.4 17 4 abnormal hindlimb morphology 0.50582626921179 0.817837403096736 0.769439775910364 0.26 17.4 17 4 abnormal digestive system physiology 0.50582626921179 0.817837403096736 0.769439775910364 0.26 17.4 17 4 abnormal palate morphology 0.541507648195807 0.867312381598552 0.767247639796659 0.259259259259259 17.4 17 4 abnormal body temperature homeostasis 0.540481137073692 0.867312381598552 0.763711936387458 0.258064516129032 17.4 17 4 abnormal circulating hormone level 0.539175234805539 0.867312381598552 0.758816347051641 0.256410256410256 17.4 17 4 abnormal axon guidance 0.538769700507734 0.867312381598552 0.757051657872451 0.255813953488372 17.4 17 4 enhanced coordination 0.584474999516236 0.869806497933974 0.73984593837535 0.25 17.4 17 4 decreased circulating progesterone level 0.584474999516236 0.869806497933974 0.73984593837535 0.25 17.4 17 4 abnormal serotonin level 0.580737694318913 0.867312381598552 0.73984593837535 0.25 17.4 17 4 curly vibrissae 0.589240060191837 0.87611156588595 0.73984593837535 0.25 17.4 17 4 decreased ovulation rate 0.589240060191837 0.87611156588595 0.73984593837535 0.25 17.4 17 4 increased body temperature 0.589240060191837 0.87611156588595 0.73984593837535 0.25 17.4 17 4 head bobbing 0.575262233472035 0.867312381598552 0.73984593837535 0.25 17.4 17 4 abnormal photoreceptor outer segment morphology 0.573205137771853 0.867312381598552 0.73984593837535 0.25 17.4 17 4 enhanced behavioral response to xenobiotic 0.595529376091438 0.885198280864925 0.73984593837535 0.25 17.4 17 4 decreased urine osmolality 0.603459206732423 0.89521403182632 0.724747041673812 0.244897959183673 17.4 17 4 short humerus 0.610065578784037 0.903565422581299 0.721800915488147 0.24390243902439 17.4 17 4 absent vibrissae 0.619251717050355 0.912282289702551 0.717426364485188 0.242424242424242 17.4 17 4 head tossing 0.619251717050355 0.912282289702551 0.717426364485188 0.242424242424242 17.4 17 4 absent long term depression 0.625348928968473 0.92099198390117 0.714334009465855 0.241379310344828 17.4 17 4 abnormal inner ear vestibule morphology 0.632963645158344 0.930798886227286 0.710252100840336 0.24 17.4 17 4 diaphragmatic hernia 0.632963645158344 0.930798886227286 0.710252100840336 0.24 17.4 17 4 abnormal energy expenditure 0.632963645158344 0.930798886227286 0.710252100840336 0.24 17.4 17 4 abnormal inner ear morphology 0.638521663282862 0.930798886227286 0.707678723663378 0.239130434782609 17.4 17 4 abnormal anxiety-related response 0.642785820305975 0.935046624567902 0.704615179405095 0.238095238095238 17.4 17 4 increased vasoconstriction 0.642785820305975 0.935046624567902 0.704615179405095 0.238095238095238 17.4 17 4 hypoalgesia 0.642785820305975 0.935046624567902 0.704615179405095 0.238095238095238 17.4 17 4 abnormal optic nerve morphology 0.643394592892406 0.935658608488664 0.704615179405095 0.238095238095238 17.4 17 4 abnormal bone remodeling 0.655788257751806 0.951538901816599 0.696325589059153 0.235294117647059 17.4 17 4 decreased pancreatic beta cell number 0.655788257751806 0.951538901816599 0.696325589059153 0.235294117647059 17.4 17 4 increased width of hypertrophic chondrocyte zone 0.655788257751806 0.951538901816599 0.696325589059153 0.235294117647059 17.4 17 4 disorganized myocardium 0.663868787269423 0.962156811166468 0.690522875816994 0.233333333333333 17.4 17 4 abnormal eye electrophysiology 0.735983212569135 1 0.684816075190407 0.231404958677686 17.4 17 4 small seminal vesicle 0.67381383514538 0.962156811166468 0.682934712346477 0.230769230769231 17.4 17 4 abnormal ocular fundus morphology 0.67381383514538 0.962156811166468 0.682934712346477 0.230769230769231 17.4 17 4 impaired behavioral response to xenobiotic 0.690176200860671 0.965044013288881 0.676430572228891 0.228571428571429 17.4 17 4 abnormal oogenesis 0.686417295265371 0.962156811166468 0.672587216704864 0.227272727272727 17.4 17 4 abnormal bone trabecula morphology 0.711615602845258 0.985054987244061 0.657640834111422 0.222222222222222 17.4 17 4 abnormal reflex 0.72230359511118 0.999293766873783 0.657640834111422 0.222222222222222 17.4 17 4 short radius 0.72230359511118 0.999293766873783 0.657640834111422 0.222222222222222 17.4 17 4 abnormal inhibitory postsynaptic currents 0.769306180733031 1 0.652805239742956 0.220588235294118 17.4 17 4 abnormal carpal bone morphology 0.726275177736932 1 0.643344294239435 0.217391304347826 17.4 17 4 abnormal crista ampullaris morphology 0.726275177736932 1 0.643344294239435 0.217391304347826 17.4 17 4 myoclonus 0.746290312844082 1 0.634153661464586 0.214285714285714 17.4 17 4 increased systemic arterial blood pressure 0.783977171798248 1 0.629656117766255 0.212765957446809 17.4 17 4 apnea 0.762337050775115 1 0.616538281979458 0.208333333333333 17.4 17 4 increased susceptibility to pharmacologically induced seizures 0.869148937812075 1 0.616538281979458 0.208333333333333 17.4 17 4 prolonged QT interval 0.762337050775115 1 0.616538281979458 0.208333333333333 17.4 17 4 abnormal lung saccule morphology 0.762337050775115 1 0.616538281979458 0.208333333333333 17.4 17 4 abnormal cartilage development 0.837356556183104 1 0.59187675070028 0.2 17.4 17 4 abnormal hair cycle 0.806333102023271 1 0.59187675070028 0.2 17.4 17 4 abnormal stomach mucosa morphology 0.794680402179308 1 0.59187675070028 0.2 17.4 17 4 abnormal systemic arterial blood pressure 0.840296639336471 1 0.575435729847495 0.194444444444444 17.4 17 4 increased insulin secretion 0.860873115589282 1 0.559883412824589 0.189189189189189 17.4 17 4 abnormal hair shaft morphology 0.888836964665097 1 0.554884453781513 0.1875 17.4 17 4 wrinkled skin 0.848876918369038 1 0.548034028426185 0.185185185185185 17.4 17 4 abnormal iris morphology 0.895517180413809 1 0.531171442936149 0.179487179487179 17.4 17 4 short ulna 0.922554414272551 1 0.505260640841703 0.170731707317073 17.4 17 4 emphysema 0.907481933638671 1 0.493230625583567 0.166666666666667 17.4 17 4 abnormal vibrissa morphology 0.933628714126311 1 0.493230625583567 0.166666666666667 17.4 17 4 palatal shelf hypoplasia 2.35290232819344e-05 0.00036017504870038 1.63425997825749 1 18.4 18 4 aorta dilation 2.35290232819344e-05 0.00036017504870038 1.63425997825749 1 18.4 18 4 dilated uterus 0.00016342514673832 0.00187336429728834 1.63425997825749 1 18.4 18 4 increased neuronal precursor cell number 0.00016342514673832 0.00187336429728834 1.63425997825749 1 18.4 18 4 positive geotaxis 0.00016342514673832 0.00187336429728834 1.63425997825749 1 18.4 18 4 craniofacial phenotype 0.000430670340075902 0.00440861099151772 1.63425997825749 1 18.4 18 4 abnormal olfactory bulb mitral cell layer morphology 0.000430670340075902 0.00440861099151772 1.63425997825749 1 18.4 18 4 pleural effusion 0.000430670340075902 0.00440861099151772 1.63425997825749 1 18.4 18 4 increased brain apoptosis 0.000430670340075902 0.00440861099151772 1.63425997825749 1 18.4 18 4 hemoglobinuria 0.00299043460123577 0.0213755921568217 1.63425997825749 1 18.4 18 4 absent ectoplacental cone 0.00299043460123577 0.0213755921568217 1.63425997825749 1 18.4 18 4 abnormal hippocampal fimbria morphology 0.00299043460123577 0.0213755921568217 1.63425997825749 1 18.4 18 4 loss of hippocampal neurons 0.00299043460123577 0.0213755921568217 1.63425997825749 1 18.4 18 4 esophageal atresia 0.00299043460123577 0.0213755921568217 1.63425997825749 1 18.4 18 4 abnormal olfactory bulb layer morphology 0.00299043460123577 0.0213755921568217 1.63425997825749 1 18.4 18 4 myocardium hypoplasia 0.00299043460123577 0.0213755921568217 1.63425997825749 1 18.4 18 4 dissociated hepatocytes 0.00787948040389311 0.0458484386074482 1.63425997825749 1 18.4 18 4 optic nerve atrophy 0.00787948040389311 0.0458484386074482 1.63425997825749 1 18.4 18 4 decreased sensitivity to skin irradiation 0.00787948040389311 0.0458484386074482 1.63425997825749 1 18.4 18 4 increased urine microalbumin level 0.00787948040389311 0.0458484386074482 1.63425997825749 1 18.4 18 4 absent uterus 0.00787948040389311 0.0458484386074482 1.63425997825749 1 18.4 18 4 abnormal response to vitamins 0.00787948040389311 0.0458484386074482 1.63425997825749 1 18.4 18 4 increased heart right ventricle weight 0.00787948040389311 0.0458484386074482 1.63425997825749 1 18.4 18 4 abnormal inner cell mass proliferation 0.00787948040389311 0.0458484386074482 1.63425997825749 1 18.4 18 4 aciduria 0.00787948040389311 0.0458484386074482 1.63425997825749 1 18.4 18 4 decreased DN3 thymocyte number 0.00787948040389311 0.0458484386074482 1.63425997825749 1 18.4 18 4 increased response to stress-induced hyperthermia 0.00787948040389311 0.0458484386074482 1.63425997825749 1 18.4 18 4 calcified aorta 0.00787948040389311 0.0458484386074482 1.63425997825749 1 18.4 18 4 prolonged ST segment 0.00787948040389311 0.0458484386074482 1.63425997825749 1 18.4 18 4 decreased heart left ventricle size 0.00787948040389311 0.0458484386074482 1.63425997825749 1 18.4 18 4 enlarged aortic valve 0.00787948040389311 0.0458484386074482 1.63425997825749 1 18.4 18 4 pale lung 0.00787948040389311 0.0458484386074482 1.63425997825749 1 18.4 18 4 abnormal lung alveolus development 0.00787948040389311 0.0458484386074482 1.63425997825749 1 18.4 18 4 delayed optic fissure closure 0.00787948040389311 0.0458484386074482 1.63425997825749 1 18.4 18 4 abnormal eyelid margin morphology 0.00787948040389311 0.0458484386074482 1.63425997825749 1 18.4 18 4 broad head 0.00113488042299389 0.00956954254982136 1.63425997825749 1 18.4 18 4 skin photosensitivity 0.00113488042299389 0.00956954254982136 1.63425997825749 1 18.4 18 4 abnormal tumor incidence 0.00113488042299389 0.00956954254982136 1.63425997825749 1 18.4 18 4 decreased cardiomyocyte apoptosis 0.00113488042299389 0.00956954254982136 1.63425997825749 1 18.4 18 4 aorta coarctation 0.00113488042299389 0.00956954254982136 1.63425997825749 1 18.4 18 4 abnormal uterus physiology 0.00113488042299389 0.00956954254982136 1.63425997825749 1 18.4 18 4 increased mortality induced by gamma-irradiation 7.0521982129371e-10 2.94829295036656e-08 1.52155239355008 0.931034482758621 18.4 18 4 midline facial cleft 3.07130090814596e-05 0.000449403588765475 1.51752712266767 0.928571428571429 18.4 18 4 increased hemangioma incidence 3.07130090814596e-05 0.000449403588765475 1.51752712266767 0.928571428571429 18.4 18 4 split sternum 3.07130090814596e-05 0.000449403588765475 1.51752712266767 0.928571428571429 18.4 18 4 abnormal embryonic growth/weight/body size 0.000184149141346024 0.00207741945169268 1.49807164673604 0.916666666666667 18.4 18 4 delayed hepatic development 0.000446835680408723 0.00451830794722235 1.48569088932499 0.909090909090909 18.4 18 4 abnormal eye distance/ position 0.000446835680408723 0.00451830794722235 1.48569088932499 0.909090909090909 18.4 18 4 abnormal radial glial cell morphology 0.000446835680408723 0.00451830794722235 1.48569088932499 0.909090909090909 18.4 18 4 pharyngeal arch hypoplasia 0.000446835680408723 0.00451830794722235 1.48569088932499 0.909090909090909 18.4 18 4 common atrioventricular valve 0.000446835680408723 0.00451830794722235 1.48569088932499 0.909090909090909 18.4 18 4 anencephaly 2.07657693492079e-06 4.28670964781366e-05 1.47083398043174 0.9 18.4 18 4 abnormal mammary gland physiology 0.00107614844746933 0.00931102352375635 1.47083398043174 0.9 18.4 18 4 abnormal respiratory mechanics 0.00107614844746933 0.00931102352375635 1.47083398043174 0.9 18.4 18 4 abnormal tibialis anterior morphology 0.00107614844746933 0.00931102352375635 1.47083398043174 0.9 18.4 18 4 decreased transitional stage T2 B cell number 0.00107614844746933 0.00931102352375635 1.47083398043174 0.9 18.4 18 4 increased circulating fructosamine level 0.00107614844746933 0.00931102352375635 1.47083398043174 0.9 18.4 18 4 decreased circulating lactate level 0.00107614844746933 0.00931102352375635 1.47083398043174 0.9 18.4 18 4 fusion of atlas and occipital bones 0.00256863188677656 0.0187374540127762 1.45267553622888 0.888888888888889 18.4 18 4 abnormal oxidative phosphorylation 0.00256863188677656 0.0187374540127762 1.45267553622888 0.888888888888889 18.4 18 4 decreased platelet dense granule number 0.00256863188677656 0.0187374540127762 1.45267553622888 0.888888888888889 18.4 18 4 increased thymocyte apoptosis 1.40239306841951e-07 3.73096551624977e-06 1.44569151922778 0.884615384615385 18.4 18 4 blindness 7.64403234383796e-07 1.69772593350865e-05 1.42997748097531 0.875 18.4 18 4 blepharitis 6.441794034958e-05 0.000832413644777041 1.42997748097531 0.875 18.4 18 4 abnormal exoccipital bone morphology 0.0060643510034198 0.0381417778027983 1.42997748097531 0.875 18.4 18 4 failure of vascular branching 0.0060643510034198 0.0381417778027983 1.42997748097531 0.875 18.4 18 4 hypospadia 0.0060643510034198 0.0381417778027983 1.42997748097531 0.875 18.4 18 4 liver cysts 0.0060643510034198 0.0381417778027983 1.42997748097531 0.875 18.4 18 4 elevated level of mitotic sister chromatid exchange 0.0060643510034198 0.0381417778027983 1.42997748097531 0.875 18.4 18 4 abnormal extraembryonic tissue physiology 0.0060643510034198 0.0381417778027983 1.42997748097531 0.875 18.4 18 4 abnormal hair follicle melanocyte morphology 0.0060643510034198 0.0381417778027983 1.42997748097531 0.875 18.4 18 4 abnormal kidney epithelium morphology 0.0060643510034198 0.0381417778027983 1.42997748097531 0.875 18.4 18 4 abnormal meiotic spindle morphology 0.0060643510034198 0.0381417778027983 1.42997748097531 0.875 18.4 18 4 abnormal cerebellum deep nucleus morphology 0.0060643510034198 0.0381417778027983 1.42997748097531 0.875 18.4 18 4 decreased quadriceps weight 0.0060643510034198 0.0381417778027983 1.42997748097531 0.875 18.4 18 4 abnormal stomach position or orientation 0.0060643510034198 0.0381417778027983 1.42997748097531 0.875 18.4 18 4 lung situs inversus 0.0060643510034198 0.0381417778027983 1.42997748097531 0.875 18.4 18 4 abnormal bronchiole epithelium morphology 0.0060643510034198 0.0381417778027983 1.42997748097531 0.875 18.4 18 4 decreased cranium length 0.0060643510034198 0.0381417778027983 1.42997748097531 0.875 18.4 18 4 increased circulating ferritin level 0.0060643510034198 0.0381417778027983 1.42997748097531 0.875 18.4 18 4 decreased basal metabolism 0.0060643510034198 0.0381417778027983 1.42997748097531 0.875 18.4 18 4 delayed intramembranous bone ossification 0.000149425559612546 0.00174096524372931 1.41635864782316 0.866666666666667 18.4 18 4 abnormal trophectoderm morphology 0.000149425559612546 0.00174096524372931 1.41635864782316 0.866666666666667 18.4 18 4 lysosomal protein accumulation 0.000343595224883506 0.00362927015667823 1.40079426707785 0.857142857142857 18.4 18 4 abnormal vitelline vein topology 0.000343595224883506 0.00362927015667823 1.40079426707785 0.857142857142857 18.4 18 4 polyphalangy 0.014123759670687 0.0711911898294507 1.40079426707785 0.857142857142857 18.4 18 4 absent epidermis stratum corneum 0.014123759670687 0.0711911898294507 1.40079426707785 0.857142857142857 18.4 18 4 limp posture 0.014123759670687 0.0711911898294507 1.40079426707785 0.857142857142857 18.4 18 4 abnormal gastrulation movements 0.014123759670687 0.0711911898294507 1.40079426707785 0.857142857142857 18.4 18 4 increased cell nucleus count 0.014123759670687 0.0711911898294507 1.40079426707785 0.857142857142857 18.4 18 4 abnormal optic tract morphology 0.014123759670687 0.0711911898294507 1.40079426707785 0.857142857142857 18.4 18 4 decreased tidal volume 0.014123759670687 0.0711911898294507 1.40079426707785 0.857142857142857 18.4 18 4 heart hemorrhage 0.014123759670687 0.0711911898294507 1.40079426707785 0.857142857142857 18.4 18 4 abnormal cerebellum white matter morphology 0.014123759670687 0.0711911898294507 1.40079426707785 0.857142857142857 18.4 18 4 decreased DN2 thymocyte number 0.014123759670687 0.0711911898294507 1.40079426707785 0.857142857142857 18.4 18 4 arteritis 0.014123759670687 0.0711911898294507 1.40079426707785 0.857142857142857 18.4 18 4 abnormal retina inner limiting membrane morphology 0.014123759670687 0.0711911898294507 1.40079426707785 0.857142857142857 18.4 18 4 coronary fistula 0.014123759670687 0.0711911898294507 1.40079426707785 0.857142857142857 18.4 18 4 abnormal aortic valve cusp morphology 0.014123759670687 0.0711911898294507 1.40079426707785 0.857142857142857 18.4 18 4 abnormal tricarboxylic acid cycle 0.014123759670687 0.0711911898294507 1.40079426707785 0.857142857142857 18.4 18 4 abnormal brain ependyma motile cilium physiology 0.014123759670687 0.0711911898294507 1.40079426707785 0.857142857142857 18.4 18 4 embryonic lethality at implantation, incomplete penetrance 0.014123759670687 0.0711911898294507 1.40079426707785 0.857142857142857 18.4 18 4 parturition failure 0.014123759670687 0.0711911898294507 1.40079426707785 0.857142857142857 18.4 18 4 small tail bud 0.014123759670687 0.0711911898294507 1.40079426707785 0.857142857142857 18.4 18 4 decreased areal bone mineral density 0.014123759670687 0.0711911898294507 1.40079426707785 0.857142857142857 18.4 18 4 decreased femur compact bone thickness 0.014123759670687 0.0711911898294507 1.40079426707785 0.857142857142857 18.4 18 4 ductus venosus stenosis 0.014123759670687 0.0711911898294507 1.40079426707785 0.857142857142857 18.4 18 4 absent ductus venosus valve 2.11961484594628e-05 0.000330566892118582 1.38912098151887 0.85 18.4 18 4 abnormal Mullerian duct morphology 1.36216455224128e-06 2.89605497752151e-05 1.38283536621788 0.846153846153846 18.4 18 4 absent myocardial trabeculae 0.000782211842099523 0.00715349984273002 1.38283536621788 0.846153846153846 18.4 18 4 abnormal grip strength 0.000782211842099523 0.00715349984273002 1.38283536621788 0.846153846153846 18.4 18 4 abnormal coping response 0.000782211842099523 0.00715349984273002 1.38283536621788 0.846153846153846 18.4 18 4 abnormal sternebra morphology 4.77847950192744e-05 0.000651313301975041 1.37621892905894 0.842105263157895 18.4 18 4 embryonic lethality between implantation and somite formation, incomplete penetrance 4.77847950192744e-05 0.000651313301975041 1.37621892905894 0.842105263157895 18.4 18 4 abnormal mitochondrial ATP synthesis coupled electron transport 2.003602261812e-07 5.00947372001492e-06 1.3706696591837 0.838709677419355 18.4 18 4 abnormal brain vasculature morphology 4.45189855376208e-07 1.04472619363049e-05 1.36188331521458 0.833333333333333 18.4 18 4 abnormal bile duct morphology 0.000106802741171504 0.00128343873750781 1.36188331521458 0.833333333333333 18.4 18 4 abnormal body wall morphology 0.000106802741171504 0.00128343873750781 1.36188331521458 0.833333333333333 18.4 18 4 abnormal thymus involution 0.0017602683757222 0.0138128314971892 1.36188331521458 0.833333333333333 18.4 18 4 interstitial pneumonia 0.0017602683757222 0.0138128314971892 1.36188331521458 0.833333333333333 18.4 18 4 increased papilloma incidence 0.0017602683757222 0.0138128314971892 1.36188331521458 0.833333333333333 18.4 18 4 dilated bile duct 0.0017602683757222 0.0138128314971892 1.36188331521458 0.833333333333333 18.4 18 4 abnormal rostral-caudal body axis extension 0.0017602683757222 0.0138128314971892 1.36188331521458 0.833333333333333 18.4 18 4 hematuria 0.0017602683757222 0.0138128314971892 1.36188331521458 0.833333333333333 18.4 18 4 abnormal fatty acid level 0.0017602683757222 0.0138128314971892 1.36188331521458 0.833333333333333 18.4 18 4 decreased renal glomerular filtration rate 0.0017602683757222 0.0138128314971892 1.36188331521458 0.833333333333333 18.4 18 4 increased fibrosarcoma incidence 0.0017602683757222 0.0138128314971892 1.36188331521458 0.833333333333333 18.4 18 4 abnormal pulmonary valve cusp morphology 0.0017602683757222 0.0138128314971892 1.36188331521458 0.833333333333333 18.4 18 4 embryonic lethality between implantation and placentation, incomplete penetrance 0.0017602683757222 0.0138128314971892 1.36188331521458 0.833333333333333 18.4 18 4 abnormal colon goblet cell morphology 0.0017602683757222 0.0138128314971892 1.36188331521458 0.833333333333333 18.4 18 4 echinocytosis 0.0323247094171798 0.133419798368693 1.36188331521458 0.833333333333333 18.4 18 4 absent organized vascular network 0.0323247094171798 0.133419798368693 1.36188331521458 0.833333333333333 18.4 18 4 thin tail 0.0323247094171798 0.133419798368693 1.36188331521458 0.833333333333333 18.4 18 4 abnormal lacrimal gland physiology 0.0323247094171798 0.133419798368693 1.36188331521458 0.833333333333333 18.4 18 4 increased embryo size 0.0323247094171798 0.133419798368693 1.36188331521458 0.833333333333333 18.4 18 4 delayed brain development 0.0323247094171798 0.133419798368693 1.36188331521458 0.833333333333333 18.4 18 4 non-obstructive hydrocephaly 0.0323247094171798 0.133419798368693 1.36188331521458 0.833333333333333 18.4 18 4 abnormal lymph node cortex morphology 0.0323247094171798 0.133419798368693 1.36188331521458 0.833333333333333 18.4 18 4 increased post-tetanic potentiation 0.0323247094171798 0.133419798368693 1.36188331521458 0.833333333333333 18.4 18 4 calcified joint 0.0323247094171798 0.133419798368693 1.36188331521458 0.833333333333333 18.4 18 4 bile duct inflammation 0.0323247094171798 0.133419798368693 1.36188331521458 0.833333333333333 18.4 18 4 decreased liver function 0.0323247094171798 0.133419798368693 1.36188331521458 0.833333333333333 18.4 18 4 impaired granulosa cell differentiation 0.0323247094171798 0.133419798368693 1.36188331521458 0.833333333333333 18.4 18 4 enlarged pancreas 0.0323247094171798 0.133419798368693 1.36188331521458 0.833333333333333 18.4 18 4 abnormal extensor digitorum longus morphology 0.0323247094171798 0.133419798368693 1.36188331521458 0.833333333333333 18.4 18 4 abnormal physical strength 0.0323247094171798 0.133419798368693 1.36188331521458 0.833333333333333 18.4 18 4 decreased prostate gland weight 0.0323247094171798 0.133419798368693 1.36188331521458 0.833333333333333 18.4 18 4 abnormal ligament morphology 0.0323247094171798 0.133419798368693 1.36188331521458 0.833333333333333 18.4 18 4 decreased platelet ADP level 0.0323247094171798 0.133419798368693 1.36188331521458 0.833333333333333 18.4 18 4 abnormal eyelid development 0.0323247094171798 0.133419798368693 1.36188331521458 0.833333333333333 18.4 18 4 delayed chorioallantoic fusion 0.0323247094171798 0.133419798368693 1.36188331521458 0.833333333333333 18.4 18 4 increased urine uric acid level 0.0323247094171798 0.133419798368693 1.36188331521458 0.833333333333333 18.4 18 4 absent sperm mitochondrial sheath 0.0323247094171798 0.133419798368693 1.36188331521458 0.833333333333333 18.4 18 4 visceral vascular congestion 0.0323247094171798 0.133419798368693 1.36188331521458 0.833333333333333 18.4 18 4 common truncal valve 0.0323247094171798 0.133419798368693 1.36188331521458 0.833333333333333 18.4 18 4 increased CD11b-high dendritic cell number 0.0323247094171798 0.133419798368693 1.36188331521458 0.833333333333333 18.4 18 4 abnormal Wolffian duct connection 0.0323247094171798 0.133419798368693 1.36188331521458 0.833333333333333 18.4 18 4 abnormal embryo morphology 0.0323247094171798 0.133419798368693 1.36188331521458 0.833333333333333 18.4 18 4 ectopic bone 0.0323247094171798 0.133419798368693 1.36188331521458 0.833333333333333 18.4 18 4 decreased capillary density 0.0323247094171798 0.133419798368693 1.36188331521458 0.833333333333333 18.4 18 4 increased cardiac cell glucose uptake 0.0323247094171798 0.133419798368693 1.36188331521458 0.833333333333333 18.4 18 4 decreased trophoblast giant cell number 9.83171252343142e-07 2.13592881240486e-05 1.35249101648896 0.827586206896552 18.4 18 4 liver hypoplasia 4.50733035562235e-11 2.36041773886539e-09 1.35140728971293 0.826923076923077 18.4 18 4 abnormal duodenum morphology 0.000236432099732703 0.00259085836160836 1.34586115856499 0.823529411764706 18.4 18 4 aminoaciduria 0.000236432099732703 0.00259085836160836 1.34586115856499 0.823529411764706 18.4 18 4 abnormal embryonic-extraembryonic boundary morphology 0.000236432099732703 0.00259085836160836 1.34586115856499 0.823529411764706 18.4 18 4 abnormal ectoplacental cone morphology 0.000236432099732703 0.00259085836160836 1.34586115856499 0.823529411764706 18.4 18 4 increased brain size 0.000236432099732703 0.00259085836160836 1.34586115856499 0.823529411764706 18.4 18 4 decreased atrioventricular cushion size 0.00390805589924205 0.026705195765675 1.33712180039249 0.818181818181818 18.4 18 4 abnormal awl hair morphology 0.00390805589924205 0.026705195765675 1.33712180039249 0.818181818181818 18.4 18 4 fatigue 0.00390805589924205 0.026705195765675 1.33712180039249 0.818181818181818 18.4 18 4 abnormal dorsal-ventral polarity of the somites 0.00390805589924205 0.026705195765675 1.33712180039249 0.818181818181818 18.4 18 4 increased glycogen level 0.00390805589924205 0.026705195765675 1.33712180039249 0.818181818181818 18.4 18 4 abnormal brain ependyma motile cilium morphology 0.00390805589924205 0.026705195765675 1.33712180039249 0.818181818181818 18.4 18 4 reduced sympathetic cervical ganglion size 0.00390805589924205 0.026705195765675 1.33712180039249 0.818181818181818 18.4 18 4 vasculature congestion 0.000517791909752063 0.00498262040815573 1.32783623233421 0.8125 18.4 18 4 poor circulation 0.000517791909752063 0.00498262040815573 1.32783623233421 0.8125 18.4 18 4 intraventricular hemorrhage 0.000517791909752063 0.00498262040815573 1.32783623233421 0.8125 18.4 18 4 abnormal branching of the mammary ductal tree 9.94519692724457e-08 2.70368058541212e-06 1.32507565804662 0.810810810810811 18.4 18 4 liver degeneration 7.16301934176235e-05 0.000918454155290405 1.3229723633513 0.80952380952381 18.4 18 4 abnormal cell cycle 4.67841427988002e-21 9.69796293433462e-19 1.32161893893867 0.808695652173913 18.4 18 4 increased cellular sensitivity to gamma-irradiation 2.17342780207098e-09 8.25404833229246e-08 1.32131657816563 0.808510638297872 18.4 18 4 abnormal eyelid morphology 1.46531331035541e-06 3.0759214004296e-05 1.31795159536895 0.806451612903226 18.4 18 4 inner cell mass degeneration 1.46531331035541e-06 3.0759214004296e-05 1.31795159536895 0.806451612903226 18.4 18 4 abnormal lysosome morphology 2.13743715471264e-07 5.31687492234769e-06 1.31648720470743 0.805555555555556 18.4 18 4 failure to gastrulate 4.65519316045837e-09 1.61955146666297e-07 1.31451346077233 0.804347826086957 18.4 18 4 abnormal liver development 4.56546227707274e-07 1.06634623607685e-05 1.30740798260599 0.8 18.4 18 4 retarded hair growth 0.00853856564400548 0.0485478446616312 1.30740798260599 0.8 18.4 18 4 rhinitis 0.00853856564400548 0.0485478446616312 1.30740798260599 0.8 18.4 18 4 ketoaciduria 0.00853856564400548 0.0485478446616312 1.30740798260599 0.8 18.4 18 4 impaired basement membrane formation 0.00853856564400548 0.0485478446616312 1.30740798260599 0.8 18.4 18 4 peritoneal inflammation 0.00853856564400548 0.0485478446616312 1.30740798260599 0.8 18.4 18 4 bifid ureter 0.00853856564400548 0.0485478446616312 1.30740798260599 0.8 18.4 18 4 increased atrioventricular cushion size 0.00853856564400548 0.0485478446616312 1.30740798260599 0.8 18.4 18 4 increased heart rate variability 0.00853856564400548 0.0485478446616312 1.30740798260599 0.8 18.4 18 4 abnormal deltoid tuberosity morphology 0.00853856564400548 0.0485478446616312 1.30740798260599 0.8 18.4 18 4 abnormal respiratory conducting tube morphology 0.00853856564400548 0.0485478446616312 1.30740798260599 0.8 18.4 18 4 abnormal corneal endothelium morphology 0.00853856564400548 0.0485478446616312 1.30740798260599 0.8 18.4 18 4 osteosclerosis 0.00853856564400548 0.0485478446616312 1.30740798260599 0.8 18.4 18 4 abnormal vibrissa follicle morphology 0.00853856564400548 0.0485478446616312 1.30740798260599 0.8 18.4 18 4 abnormal heart and great artery attachment 0.00853856564400548 0.0485478446616312 1.30740798260599 0.8 18.4 18 4 fusion of atlas and odontoid process 0.00853856564400548 0.0485478446616312 1.30740798260599 0.8 18.4 18 4 abnormal adaptive thermogenesis 0.00853856564400548 0.0485478446616312 1.30740798260599 0.8 18.4 18 4 lethality during fetal growth through weaning, complete penetrance 0.00853856564400548 0.0485478446616312 1.30740798260599 0.8 18.4 18 4 abnormal myocardial trabeculae morphology 9.92130051882657e-09 3.22604379615439e-07 1.30740798260599 0.8 18.4 18 4 immune system phenotype 0.00112027388596735 0.00954342907994444 1.30740798260599 0.8 18.4 18 4 abnormal energy homeostasis 0.00112027388596735 0.00954342907994444 1.30740798260599 0.8 18.4 18 4 abnormal secondary palate development 0.00112027388596735 0.00954342907994444 1.30740798260599 0.8 18.4 18 4 liver vascular congestion 0.00112027388596735 0.00954342907994444 1.30740798260599 0.8 18.4 18 4 heterochrony 0.00112027388596735 0.00954342907994444 1.30740798260599 0.8 18.4 18 4 abnormal brown adipose tissue morphology 9.68776207454606e-07 2.11388668073976e-05 1.29779468861624 0.794117647058823 18.4 18 4 vertebral transformation 6.59475318935864e-09 2.20193940382948e-07 1.29378914945385 0.791666666666667 18.4 18 4 abnormal vitelline vasculature morphology 1.99785166313527e-19 3.10603500753062e-17 1.29319702627332 0.791304347826087 18.4 18 4 decreased hair follicle number 2.99882008578146e-07 7.27762435451843e-06 1.29020524599276 0.789473684210526 18.4 18 4 irregular coat pigmentation 0.000328120039242367 0.00350299827302742 1.29020524599276 0.789473684210526 18.4 18 4 kinked neural tube 2.06765513429785e-09 7.91275714856294e-08 1.28855113670302 0.788461538461538 18.4 18 4 abnormal cell nucleus morphology 1.38377249864917e-08 4.47030401349328e-07 1.28654508926654 0.787234042553192 18.4 18 4 lymphoid hyperplasia 1.40219830539358e-05 0.000231758690011065 1.28406141148803 0.785714285714286 18.4 18 4 abnormal somite shape 1.40219830539358e-05 0.000231758690011065 1.28406141148803 0.785714285714286 18.4 18 4 premature aging 1.40219830539358e-05 0.000231758690011065 1.28406141148803 0.785714285714286 18.4 18 4 abnormal mitotic spindle morphology 1.40219830539358e-05 0.000231758690011065 1.28406141148803 0.785714285714286 18.4 18 4 irregularly shaped pupil 0.00239047277189159 0.0177766846639173 1.28406141148803 0.785714285714286 18.4 18 4 increased lactate dehydrogenase level 0.00239047277189159 0.0177766846639173 1.28406141148803 0.785714285714286 18.4 18 4 absent olfactory bulb 0.00239047277189159 0.0177766846639173 1.28406141148803 0.785714285714286 18.4 18 4 premature hair loss 0.00239047277189159 0.0177766846639173 1.28406141148803 0.785714285714286 18.4 18 4 spina bifida occulta 0.00239047277189159 0.0177766846639173 1.28406141148803 0.785714285714286 18.4 18 4 abnormal renal tubule epithelial cell primary cilium morphology 0.00239047277189159 0.0177766846639173 1.28406141148803 0.785714285714286 18.4 18 4 testis degeneration 0.00239047277189159 0.0177766846639173 1.28406141148803 0.785714285714286 18.4 18 4 multiple persisting craniopharyngeal ducts 0.00239047277189159 0.0177766846639173 1.28406141148803 0.785714285714286 18.4 18 4 abnormal extraembryonic tissue morphology 7.85792616959548e-17 9.75008282649829e-15 1.28177253196666 0.784313725490196 18.4 18 4 abnormal respiratory electron transport chain 6.28051295441972e-07 1.40745729496568e-05 1.28090646944506 0.783783783783784 18.4 18 4 abnormal hematopoietic stem cell physiology 9.75053702728504e-05 0.00118603720564164 1.27898606994065 0.782608695652174 18.4 18 4 kidney cortex cysts 4.26979178368379e-06 8.20162707483662e-05 1.27676560801367 0.78125 18.4 18 4 increased fibroblast apoptosis 4.26979178368379e-06 8.20162707483662e-05 1.27676560801367 0.78125 18.4 18 4 abnormal cell morphology 2.50350140027928e-18 3.55854841896841e-16 1.27586963214839 0.780701754385965 18.4 18 4 abnormal cell differentiation 1.93772725702158e-07 4.96917170292905e-06 1.27551998303024 0.780487804878049 18.4 18 4 palatal shelves fail to meet at midline 1.93772725702158e-07 4.96917170292905e-06 1.27551998303024 0.780487804878049 18.4 18 4 embryonic lethality between implantation and somite formation, complete penetrance 1.52982549941663e-37 6.9189835087252e-35 1.27405573815176 0.779591836734694 18.4 18 4 abnormal trigeminal ganglion morphology 2.92777474607418e-05 0.000433502361955924 1.27109109420027 0.777777777777778 18.4 18 4 increased brain weight 2.92777474607418e-05 0.000433502361955924 1.27109109420027 0.777777777777778 18.4 18 4 abnormal skin appearance 2.92777474607418e-05 0.000433502361955924 1.27109109420027 0.777777777777778 18.4 18 4 delayed kidney development 0.000690134854696898 0.0064296271575226 1.27109109420027 0.777777777777778 18.4 18 4 decreased cellular sensitivity to gamma-irradiation 0.000690134854696898 0.0064296271575226 1.27109109420027 0.777777777777778 18.4 18 4 abnormal glycogen homeostasis 0.000690134854696898 0.0064296271575226 1.27109109420027 0.777777777777778 18.4 18 4 decreased tumor latency 0.000690134854696898 0.0064296271575226 1.27109109420027 0.777777777777778 18.4 18 4 heart hyperplasia 0.0182993679116712 0.0875378416928501 1.27109109420027 0.777777777777778 18.4 18 4 distorted hair follicle pattern 0.0182993679116712 0.0875378416928501 1.27109109420027 0.777777777777778 18.4 18 4 renal tubular acidosis 0.0182993679116712 0.0875378416928501 1.27109109420027 0.777777777777778 18.4 18 4 abnormal urinary bladder urothelium morphology 0.0182993679116712 0.0875378416928501 1.27109109420027 0.777777777777778 18.4 18 4 abnormal geniculate ganglion morphology 0.0182993679116712 0.0875378416928501 1.27109109420027 0.777777777777778 18.4 18 4 abnormal ion homeostasis 0.0182993679116712 0.0875378416928501 1.27109109420027 0.777777777777778 18.4 18 4 increased pheochromocytoma incidence 0.0182993679116712 0.0875378416928501 1.27109109420027 0.777777777777778 18.4 18 4 abnormal germ cell morphology 0.0182993679116712 0.0875378416928501 1.27109109420027 0.777777777777778 18.4 18 4 decreased circulating bicarbonate level 0.0182993679116712 0.0875378416928501 1.27109109420027 0.777777777777778 18.4 18 4 biliary cyst 0.0182993679116712 0.0875378416928501 1.27109109420027 0.777777777777778 18.4 18 4 pancreas cysts 0.0182993679116712 0.0875378416928501 1.27109109420027 0.777777777777778 18.4 18 4 decreased fear-related response 0.0182993679116712 0.0875378416928501 1.27109109420027 0.777777777777778 18.4 18 4 abnormal thymus physiology 0.0182993679116712 0.0875378416928501 1.27109109420027 0.777777777777778 18.4 18 4 decreased cellular sensitivity to ionizing radiation 0.0182993679116712 0.0875378416928501 1.27109109420027 0.777777777777778 18.4 18 4 abnormal posterior eye segment morphology 0.0182993679116712 0.0875378416928501 1.27109109420027 0.777777777777778 18.4 18 4 hemothorax 0.0182993679116712 0.0875378416928501 1.27109109420027 0.777777777777778 18.4 18 4 abnormal inguinal fat pad morphology 0.0182993679116712 0.0875378416928501 1.27109109420027 0.777777777777778 18.4 18 4 decreased transitional stage T1 B cell number 0.0182993679116712 0.0875378416928501 1.27109109420027 0.777777777777778 18.4 18 4 abnormal cerebellar layer morphology 0.0182993679116712 0.0875378416928501 1.27109109420027 0.777777777777778 18.4 18 4 prolonged RR interval 0.0182993679116712 0.0875378416928501 1.27109109420027 0.777777777777778 18.4 18 4 increased myeloid cell number 0.0182993679116712 0.0875378416928501 1.27109109420027 0.777777777777778 18.4 18 4 trigeminal neuroma 0.0182993679116712 0.0875378416928501 1.27109109420027 0.777777777777778 18.4 18 4 abnormal ductus venosus valve topology 0.0182993679116712 0.0875378416928501 1.27109109420027 0.777777777777778 18.4 18 4 abnormal infrahyoid muscle connection 0.0182993679116712 0.0875378416928501 1.27109109420027 0.777777777777778 18.4 18 4 increased cardiac muscle glycogen level 0.0182993679116712 0.0875378416928501 1.27109109420027 0.777777777777778 18.4 18 4 decreased fatty acid oxidation 0.0182993679116712 0.0875378416928501 1.27109109420027 0.777777777777778 18.4 18 4 cerebellum atrophy 0.0182993679116712 0.0875378416928501 1.27109109420027 0.777777777777778 18.4 18 4 abnormal embryonic neuroepithelium morphology 8.72284209491731e-10 3.61634495185114e-08 1.2679603279584 0.775862068965517 18.4 18 4 enlarged kidney 5.76779424065549e-09 1.95202560185449e-07 1.26423885110485 0.773584905660377 18.4 18 4 abnormal germ layer development 0.000203098775278828 0.00227059866744307 1.26283725592624 0.772727272727273 18.4 18 4 abnormal occipital bone morphology 0.000203098775278828 0.00227059866744307 1.26283725592624 0.772727272727273 18.4 18 4 abnormal circulating amino acid level 1.79382797929823e-09 7.08277317222913e-08 1.26153401830403 0.771929824561403 18.4 18 4 abnormal erythropoiesis 2.93465550707426e-16 3.17389372775966e-14 1.26071484037007 0.771428571428571 18.4 18 4 kidney cysts 8.3248333377917e-12 5.11309208092762e-10 1.25882187514429 0.77027027027027 18.4 18 4 increased leukemia incidence 6.05585110379568e-05 0.000786628178626202 1.25712306019807 0.769230769230769 18.4 18 4 excessive scratching 0.00502045682113114 0.0327779169096161 1.25712306019807 0.769230769230769 18.4 18 4 dystrophic cardiac calcinosis 0.00502045682113114 0.0327779169096161 1.25712306019807 0.769230769230769 18.4 18 4 axonal dystrophy 0.00502045682113114 0.0327779169096161 1.25712306019807 0.769230769230769 18.4 18 4 tracheoesophageal fistula 0.00502045682113114 0.0327779169096161 1.25712306019807 0.769230769230769 18.4 18 4 absent hypoglossal nerve 0.00502045682113114 0.0327779169096161 1.25712306019807 0.769230769230769 18.4 18 4 abnormal axon morphology 1.88723974358767e-16 2.08644838318859e-14 1.25595905736456 0.768518518518518 18.4 18 4 astrocytosis 1.69916359979476e-11 9.94510459879873e-10 1.25367888743041 0.767123287671233 18.4 18 4 oxidative stress 8.0324910486882e-14 6.5510890110203e-12 1.25293264999741 0.766666666666667 18.4 18 4 pericardial edema 1.10702090205187e-10 5.39944018402751e-09 1.24972821866749 0.764705882352941 18.4 18 4 abnormal direction of heart looping 5.52746161019541e-06 0.000102227217511978 1.24972821866749 0.764705882352941 18.4 18 4 absence seizures 0.00143221129231498 0.0116436473450504 1.24972821866749 0.764705882352941 18.4 18 4 abnormal involuntary movement 0.00143221129231498 0.0116436473450504 1.24972821866749 0.764705882352941 18.4 18 4 abnormal ductus venosus valve morphology 0.00143221129231498 0.0116436473450504 1.24972821866749 0.764705882352941 18.4 18 4 abnormal embryo turning 7.47377287614129e-09 2.47880133725353e-07 1.24798034703299 0.763636363636364 18.4 18 4 abnormal reproductive system morphology 5.16288224400057e-07 1.18913607240291e-05 1.24515045962476 0.761904761904762 18.4 18 4 abnormal embryonic/fetal subventricular zone morphology 0.000418168782349391 0.00433414519205879 1.24515045962476 0.761904761904762 18.4 18 4 embryonic lethality at implantation, complete penetrance 0.000418168782349391 0.00433414519205879 1.24515045962476 0.761904761904762 18.4 18 4 absent segment of posterior cerebral artery 0.000418168782349391 0.00433414519205879 1.24515045962476 0.761904761904762 18.4 18 4 abnormal interventricular septum morphology 4.89525399252918e-08 1.44105849780075e-06 1.2420375834757 0.76 18.4 18 4 spontaneous skin ulceration 0.000123989410900994 0.00147571129002978 1.2420375834757 0.76 18.4 18 4 abnormal egg cylinder morphology 0.000123989410900994 0.00147571129002978 1.2420375834757 0.76 18.4 18 4 abnormal preimplantation embryo development 0.000123989410900994 0.00147571129002978 1.2420375834757 0.76 18.4 18 4 blood in lymph vessels 3.71684738467495e-05 0.000525321469851076 1.23978343178155 0.758620689655172 18.4 18 4 enlarged pericardium 1.12334908985611e-05 0.000196093393755585 1.23807574110416 0.757575757575758 18.4 18 4 decreased brown adipose tissue amount 1.12334908985611e-05 0.000196093393755585 1.23807574110416 0.757575757575758 18.4 18 4 embryonic lethality between somite formation and embryo turning, complete penetrance 1.40985455812961e-10 6.74425617951425e-09 1.2373682692521 0.757142857142857 18.4 18 4 abnormal chromosome morphology 3.41663327637305e-06 6.79910021998238e-05 1.23673728084351 0.756756756756757 18.4 18 4 increased embryonic tissue cell apoptosis 1.37185180297604e-11 8.22284665036843e-10 1.23617100919477 0.756410256410256 18.4 18 4 abnormal embryonic tissue morphology 1.88311325965457e-20 3.46981054325241e-18 1.23403304480668 0.755102040816326 18.4 18 4 abnormal facial morphology 9.43608189153385e-09 3.08845443489348e-07 1.2328627906153 0.754385964912281 18.4 18 4 anophthalmia 8.39472369128552e-13 6.14172799472727e-11 1.23028560160957 0.752808988764045 18.4 18 4 hydrops fetalis 1.76108142492007e-10 8.18820569063304e-09 1.22569498369312 0.75 18.4 18 4 abnormal basioccipital bone morphology 0.000850062013193908 0.00753842872663047 1.22569498369312 0.75 18.4 18 4 spleen atrophy 0.000850062013193908 0.00753842872663047 1.22569498369312 0.75 18.4 18 4 abnormal placenta vasculature 6.10419182406129e-08 1.74530771981063e-06 1.22569498369312 0.75 18.4 18 4 overriding aortic valve 1.97823524144746e-07 5.00947372001492e-06 1.22569498369312 0.75 18.4 18 4 small heart 1.97823524144746e-07 5.00947372001492e-06 1.22569498369312 0.75 18.4 18 4 abnormal embryonic hematopoiesis 2.26309004192388e-05 0.000350743705874495 1.22569498369312 0.75 18.4 18 4 abnormal brainstem morphology 7.50450406811592e-05 0.000954856975418842 1.22569498369312 0.75 18.4 18 4 white spotting 0.0029277198146132 0.0211399217383174 1.22569498369312 0.75 18.4 18 4 small pancreas 0.0029277198146132 0.0211399217383174 1.22569498369312 0.75 18.4 18 4 dystonia 0.0029277198146132 0.0211399217383174 1.22569498369312 0.75 18.4 18 4 kidney degeneration 0.0029277198146132 0.0211399217383174 1.22569498369312 0.75 18.4 18 4 abnormal mating frequency 0.0103514184698016 0.0576688766934636 1.22569498369312 0.75 18.4 18 4 impaired embryo implantation 0.0103514184698016 0.0576688766934636 1.22569498369312 0.75 18.4 18 4 altered tumor susceptibility 0.0103514184698016 0.0576688766934636 1.22569498369312 0.75 18.4 18 4 loss of dopaminergic neurons 0.0103514184698016 0.0576688766934636 1.22569498369312 0.75 18.4 18 4 abnormal vascular endothelial cell development 0.0103514184698016 0.0576688766934636 1.22569498369312 0.75 18.4 18 4 absent ovary 0.0103514184698016 0.0576688766934636 1.22569498369312 0.75 18.4 18 4 decreased left ventricle systolic pressure 0.0103514184698016 0.0576688766934636 1.22569498369312 0.75 18.4 18 4 increased hepatocyte proliferation 0.0103514184698016 0.0576688766934636 1.22569498369312 0.75 18.4 18 4 pale placenta 0.0103514184698016 0.0576688766934636 1.22569498369312 0.75 18.4 18 4 decreased red blood cell distribution width 0.0103514184698016 0.0576688766934636 1.22569498369312 0.75 18.4 18 4 decreased mammary gland epithelial cell proliferation 0.0103514184698016 0.0576688766934636 1.22569498369312 0.75 18.4 18 4 abnormal hypoglossal nerve morphology 0.0383019856724886 0.151112116352602 1.22569498369312 0.75 18.4 18 4 dry eyes 0.0383019856724886 0.151112116352602 1.22569498369312 0.75 18.4 18 4 absent eyelids 0.0383019856724886 0.151112116352602 1.22569498369312 0.75 18.4 18 4 abnormal atrial thrombosis 0.0383019856724886 0.151112116352602 1.22569498369312 0.75 18.4 18 4 early eyelid opening 0.0383019856724886 0.151112116352602 1.22569498369312 0.75 18.4 18 4 abnormal soft palate morphology 0.0383019856724886 0.151112116352602 1.22569498369312 0.75 18.4 18 4 calcified muscle 0.0383019856724886 0.151112116352602 1.22569498369312 0.75 18.4 18 4 binucleate 0.0383019856724886 0.151112116352602 1.22569498369312 0.75 18.4 18 4 tau protein deposits 0.0383019856724886 0.151112116352602 1.22569498369312 0.75 18.4 18 4 accumulation of giant lysosomes in kidney/renal tubule cells 0.0383019856724886 0.151112116352602 1.22569498369312 0.75 18.4 18 4 abnormal somite size 0.0383019856724886 0.151112116352602 1.22569498369312 0.75 18.4 18 4 Sertoli cell hypoplasia 0.0383019856724886 0.151112116352602 1.22569498369312 0.75 18.4 18 4 abnormal mitotic spindle assembly checkpoint 0.0383019856724886 0.151112116352602 1.22569498369312 0.75 18.4 18 4 abnormal olfactory bulb glomerular layer morphology 0.0383019856724886 0.151112116352602 1.22569498369312 0.75 18.4 18 4 increased caudal vertebrae number 0.0383019856724886 0.151112116352602 1.22569498369312 0.75 18.4 18 4 abnormal brain ependyma morphology 0.0383019856724886 0.151112116352602 1.22569498369312 0.75 18.4 18 4 heart right ventricle hypoplasia 0.0383019856724886 0.151112116352602 1.22569498369312 0.75 18.4 18 4 abnormal hepatic vein morphology 0.0383019856724886 0.151112116352602 1.22569498369312 0.75 18.4 18 4 myocardial trabeculae hypoplasia 0.0383019856724886 0.151112116352602 1.22569498369312 0.75 18.4 18 4 abnormal visual evoked potential 0.0383019856724886 0.151112116352602 1.22569498369312 0.75 18.4 18 4 abnormal pulmonary acinus morphology 0.0383019856724886 0.151112116352602 1.22569498369312 0.75 18.4 18 4 abnormal foramen magnum morphology 0.0383019856724886 0.151112116352602 1.22569498369312 0.75 18.4 18 4 abnormal macrophage activation involved in immune response 0.0383019856724886 0.151112116352602 1.22569498369312 0.75 18.4 18 4 lethality during fetal growth through weaning, incomplete penetrance 0.0383019856724886 0.151112116352602 1.22569498369312 0.75 18.4 18 4 abnormal heart echocardiography feature 0.0383019856724886 0.151112116352602 1.22569498369312 0.75 18.4 18 4 shortened PQ interval 0.0383019856724886 0.151112116352602 1.22569498369312 0.75 18.4 18 4 increased cornea thickness 0.0383019856724886 0.151112116352602 1.22569498369312 0.75 18.4 18 4 absent hypoglossal canal 0.0383019856724886 0.151112116352602 1.22569498369312 0.75 18.4 18 4 retropleural edema 0.0383019856724886 0.151112116352602 1.22569498369312 0.75 18.4 18 4 embryo cyst 0.0383019856724886 0.151112116352602 1.22569498369312 0.75 18.4 18 4 abnormal neural tube closure 1.06484138554906e-11 6.46047060134947e-10 1.22077251387909 0.746987951807229 18.4 18 4 delayed endochondral bone ossification 1.28083017288861e-06 2.74660780608657e-05 1.21619347219162 0.744186046511628 18.4 18 4 small liver 6.74819651607621e-11 3.35722776674791e-09 1.21521895819147 0.743589743589744 18.4 18 4 lethality throughout fetal growth and development, incomplete penetrance 4.32617141683522e-23 1.26604134110325e-20 1.21428255367736 0.743016759776536 18.4 18 4 decreased glycogen level 1.37027549155769e-05 0.000229532679141398 1.21402169813414 0.742857142857143 18.4 18 4 embryonic growth arrest 4.94888366480227e-29 1.75862115945652e-26 1.21320609739639 0.74235807860262 18.4 18 4 abnormal capillary morphology 4.51677150910479e-05 0.000622463663650868 1.21251546773943 0.741935483870968 18.4 18 4 pale kidney 4.51677150910479e-05 0.000622463663650868 1.21251546773943 0.741935483870968 18.4 18 4 neurodegeneration 7.4334689828987e-08 2.05452823277339e-06 1.2105629468574 0.740740740740741 18.4 18 4 decreased circulating fructosamine level 0.000149932121258571 0.00174278575528363 1.2105629468574 0.740740740740741 18.4 18 4 increased B cell derived lymphoma incidence 2.40333967687457e-07 5.94856462310995e-06 1.20935238391055 0.74 18.4 18 4 abnormal sternum morphology 1.3656520171948e-09 5.52367380938546e-08 1.20793128827728 0.739130434782609 18.4 18 4 abnormal sacral vertebrae morphology 0.00050228008946243 0.00487103985394852 1.20793128827728 0.739130434782609 18.4 18 4 decreased embryo size 6.17931206003211e-58 6.14841549973195e-55 1.20689073708137 0.738493723849372 18.4 18 4 increased hepatocellular carcinoma incidence 4.53323685027936e-08 1.34243174584166e-06 1.20419156292657 0.736842105263158 18.4 18 4 thin dermal layer 0.00170377633796958 0.0136274715135027 1.20419156292657 0.736842105263158 18.4 18 4 abnormal stationary movement 0.00170377633796958 0.0136274715135027 1.20419156292657 0.736842105263158 18.4 18 4 increased malignant tumor incidence 0.00170377633796958 0.0136274715135027 1.20419156292657 0.736842105263158 18.4 18 4 decreased germ cell number 0.00170377633796958 0.0136274715135027 1.20419156292657 0.736842105263158 18.4 18 4 abnormal metatarsal bone morphology 0.00170377633796958 0.0136274715135027 1.20419156292657 0.736842105263158 18.4 18 4 decreased eye pigmentation 0.00170377633796958 0.0136274715135027 1.20419156292657 0.736842105263158 18.4 18 4 embryonic lethality before implantation, complete penetrance 5.62159911271155e-16 5.95052246505105e-14 1.20281534399752 0.736 18.4 18 4 atrioventricular septal defect 1.46168615347469e-07 3.86802585826413e-06 1.20256866324608 0.735849056603774 18.4 18 4 enlarged liver sinusoidal spaces 2.70835722551325e-05 0.000409546419359527 1.20166174871875 0.735294117647059 18.4 18 4 abnormal somite development 1.59727449446496e-10 7.49664208487092e-09 1.19983643973335 0.734177215189873 18.4 18 4 embryonic lethality, complete penetrance 5.20390829129144e-38 2.58894437491749e-35 1.19879885552431 0.733542319749216 18.4 18 4 delayed eyelid opening 8.92498707117377e-05 0.00109364065712043 1.19845731738883 0.733333333333333 18.4 18 4 abnormal cellular respiration 8.92498707117377e-05 0.00109364065712043 1.19845731738883 0.733333333333333 18.4 18 4 absent incisors 0.00588351970818327 0.0378171970907129 1.19845731738883 0.733333333333333 18.4 18 4 interdigital webbing 0.00588351970818327 0.0378171970907129 1.19845731738883 0.733333333333333 18.4 18 4 no suckling reflex 0.00588351970818327 0.0378171970907129 1.19845731738883 0.733333333333333 18.4 18 4 audiogenic seizures 0.00588351970818327 0.0378171970907129 1.19845731738883 0.733333333333333 18.4 18 4 abnormal placenta size 0.00588351970818327 0.0378171970907129 1.19845731738883 0.733333333333333 18.4 18 4 abnormal coronary vessel morphology 0.00588351970818327 0.0378171970907129 1.19845731738883 0.733333333333333 18.4 18 4 decreased brown adipose tissue mass 0.00588351970818327 0.0378171970907129 1.19845731738883 0.733333333333333 18.4 18 4 increased circulating creatinine level 3.05797928866951e-11 1.6903829956812e-09 1.19719044918863 0.732558139534884 18.4 18 4 abnormal developmental patterning 9.74941831943659e-11 4.80231248902941e-09 1.19579998409085 0.731707317073171 18.4 18 4 ventricular hypoplasia 0.000296158996243525 0.00317541165153349 1.19426690718817 0.730769230769231 18.4 18 4 abnormal ureter morphology 0.000296158996243525 0.00317541165153349 1.19426690718817 0.730769230769231 18.4 18 4 abnormal nerve conduction 0.000296158996243525 0.00317541165153349 1.19426690718817 0.730769230769231 18.4 18 4 gliosis 1.67325940584274e-08 5.37062293165655e-07 1.19326919047373 0.73015873015873 18.4 18 4 pale liver 9.92676590297347e-10 4.08145953448703e-08 1.19256809224195 0.72972972972973 18.4 18 4 increased circulating phosphate level 1.61983247845803e-05 0.000265962593410188 1.19256809224195 0.72972972972973 18.4 18 4 increased neuron apoptosis 1.8918774543578e-10 8.63494526186243e-09 1.19038689774311 0.728395061728395 18.4 18 4 decreased birth body size 4.16020675191409e-14 3.69589796263796e-12 1.18985594908221 0.728070175438597 18.4 18 4 abnormal head morphology 1.72362229570188e-07 4.48953974927585e-06 1.18855271146 0.727272727272727 18.4 18 4 decreased circulating total protein level 1.72362229570188e-07 4.48953974927585e-06 1.18855271146 0.727272727272727 18.4 18 4 increased cardiomyocyte apoptosis 5.30239924743789e-05 0.000709124630537728 1.18855271146 0.727272727272727 18.4 18 4 intracerebral hemorrhage 0.00099168880120423 0.00868600666547719 1.18855271146 0.727272727272727 18.4 18 4 aphakia 0.00099168880120423 0.00868600666547719 1.18855271146 0.727272727272727 18.4 18 4 abnormal lysosome physiology 0.00099168880120423 0.00868600666547719 1.18855271146 0.727272727272727 18.4 18 4 abnormal basement membrane morphology 0.00099168880120423 0.00868600666547719 1.18855271146 0.727272727272727 18.4 18 4 abnormal thrombopoiesis 0.0208865916300413 0.0954582475372397 1.18855271146 0.727272727272727 18.4 18 4 abnormal glossopharyngeal ganglion morphology 0.0208865916300413 0.0954582475372397 1.18855271146 0.727272727272727 18.4 18 4 failure of somite differentiation 0.0208865916300413 0.0954582475372397 1.18855271146 0.727272727272727 18.4 18 4 loss of cortex neurons 0.0208865916300413 0.0954582475372397 1.18855271146 0.727272727272727 18.4 18 4 abnormal spinal cord ventral horn morphology 0.0208865916300413 0.0954582475372397 1.18855271146 0.727272727272727 18.4 18 4 abnormal palate development 0.0208865916300413 0.0954582475372397 1.18855271146 0.727272727272727 18.4 18 4 abnormal palatal shelf elevation 0.0208865916300413 0.0954582475372397 1.18855271146 0.727272727272727 18.4 18 4 hypolactation 0.0208865916300413 0.0954582475372397 1.18855271146 0.727272727272727 18.4 18 4 seminiferous tubule degeneration 1.92166158738829e-09 7.46895812285682e-08 1.18651751846092 0.726027397260274 18.4 18 4 failure of chorioallantoic fusion 5.54390779263346e-07 1.25940371088363e-05 1.18563959206916 0.725490196078431 18.4 18 4 small spleen 2.19520188382989e-11 1.2270931878712e-09 1.18528745675818 0.725274725274725 18.4 18 4 perimembraneous ventricular septal defect 6.12944508248491e-09 2.06040468144341e-07 1.18424636105615 0.72463768115942 18.4 18 4 lordosis 0.000174471028621484 0.00197271219861792 1.18342963942784 0.724137931034483 18.4 18 4 short sternum 0.000174471028621484 0.00197271219861792 1.18342963942784 0.724137931034483 18.4 18 4 pale yolk sac 2.21323360597495e-10 9.99867010187465e-09 1.18139275536686 0.72289156626506 18.4 18 4 narrow eye opening 3.14649420095774e-05 0.000459055972133864 1.18029887318597 0.722222222222222 18.4 18 4 abnormal radius morphology 0.00336161003012199 0.0235549435209252 1.18029887318597 0.722222222222222 18.4 18 4 absent spleen 0.00336161003012199 0.0235549435209252 1.18029887318597 0.722222222222222 18.4 18 4 absent ureter 0.00336161003012199 0.0235549435209252 1.18029887318597 0.722222222222222 18.4 18 4 darkened coat color 0.00336161003012199 0.0235549435209252 1.18029887318597 0.722222222222222 18.4 18 4 decreased lactate dehydrogenase level 0.00336161003012199 0.0235549435209252 1.18029887318597 0.722222222222222 18.4 18 4 primary atelectasis 0.00336161003012199 0.0235549435209252 1.18029887318597 0.722222222222222 18.4 18 4 increased effector memory CD4-positive, alpha-beta T cell number 0.00336161003012199 0.0235549435209252 1.18029887318597 0.722222222222222 18.4 18 4 increased effector memory CD8-positive, alpha-beta T cell number 0.00336161003012199 0.0235549435209252 1.18029887318597 0.722222222222222 18.4 18 4 abnormal aerobic respiration 0.00336161003012199 0.0235549435209252 1.18029887318597 0.722222222222222 18.4 18 4 increased adipocyte glucose uptake 0.00336161003012199 0.0235549435209252 1.18029887318597 0.722222222222222 18.4 18 4 decreased oxygen consumption 5.76652083424685e-06 0.00010586140645896 1.17818742618563 0.720930232558139 18.4 18 4 ventricular septal defect 6.66273189883761e-16 6.90564399931606e-14 1.17762851374437 0.720588235294118 18.4 18 4 increased cellular sensitivity to ionizing radiation 0.000577828973383608 0.00550708648004493 1.1766671843454 0.72 18.4 18 4 increased liver glycogen level 0.000577828973383608 0.00550708648004493 1.1766671843454 0.72 18.4 18 4 embryonic lethality during organogenesis, complete penetrance 7.99979526463968e-61 9.9497453603956e-58 1.17608352006745 0.719642857142857 18.4 18 4 double outlet right ventricle 9.35888699440649e-13 6.61633273914443e-11 1.17605624603577 0.719626168224299 18.4 18 4 preweaning lethality, complete penetrance 7.08235007779536e-80 3.52346916370319e-76 1.17490041680133 0.718918918918919 18.4 18 4 decreased cell proliferation 6.55273884735279e-21 1.30399503062321e-18 1.17490041680133 0.718918918918919 18.4 18 4 scoliosis 0.000102761797030115 0.00124087364132238 1.17462435937257 0.71875 18.4 18 4 increased hepatocyte apoptosis 1.86588802390272e-05 0.000299444932868258 1.17331485618487 0.717948717948718 18.4 18 4 atrial septal defect 3.43548510186007e-06 6.8093778413362e-05 1.17240389744559 0.717391304347826 18.4 18 4 absent mesoderm 1.19676541409346e-07 3.21832861357566e-06 1.17121965108454 0.716666666666667 18.4 18 4 rib fusion 2.25459527068071e-08 7.14433851696594e-07 1.17081311875164 0.716417910447761 18.4 18 4 lethality throughout fetal growth and development, complete penetrance 4.58289674747096e-21 9.69796293433462e-19 1.1697860897001 0.715789473684211 18.4 18 4 pallor 2.34537503193465e-19 3.53583054056814e-17 1.16732855589821 0.714285714285714 18.4 18 4 holoprosencephaly 6.05356156040218e-05 0.000786628178626202 1.16732855589821 0.714285714285714 18.4 18 4 decreased triglyceride level 6.05356156040218e-05 0.000786628178626202 1.16732855589821 0.714285714285714 18.4 18 4 shortened head 0.0003371498227021 0.00358401788021997 1.16732855589821 0.714285714285714 18.4 18 4 subcutaneous edema 0.0003371498227021 0.00358401788021997 1.16732855589821 0.714285714285714 18.4 18 4 abnormal eye pigmentation 0.0019297950903052 0.0149544089941875 1.16732855589821 0.714285714285714 18.4 18 4 increased incidence of induced tumors 0.0019297950903052 0.0149544089941875 1.16732855589821 0.714285714285714 18.4 18 4 left pulmonary isomerism 0.0019297950903052 0.0149544089941875 1.16732855589821 0.714285714285714 18.4 18 4 vascular ring 0.0019297950903052 0.0149544089941875 1.16732855589821 0.714285714285714 18.4 18 4 abnormal placing response 0.01159541694423 0.0633229410510913 1.16732855589821 0.714285714285714 18.4 18 4 abnormal ventral body wall morphology 0.01159541694423 0.0633229410510913 1.16732855589821 0.714285714285714 18.4 18 4 abnormal vascular endothelial cell migration 0.01159541694423 0.0633229410510913 1.16732855589821 0.714285714285714 18.4 18 4 vascular smooth muscle hypoplasia 0.01159541694423 0.0633229410510913 1.16732855589821 0.714285714285714 18.4 18 4 decreased CNS synapse formation 0.01159541694423 0.0633229410510913 1.16732855589821 0.714285714285714 18.4 18 4 increased circulating growth hormone level 0.01159541694423 0.0633229410510913 1.16732855589821 0.714285714285714 18.4 18 4 abnormal glucose tolerance 0.01159541694423 0.0633229410510913 1.16732855589821 0.714285714285714 18.4 18 4 growth retardation of molars 0.0778270837834116 0.234164528527763 1.16732855589821 0.714285714285714 18.4 18 4 asymmetric rib joints 0.0778270837834116 0.234164528527763 1.16732855589821 0.714285714285714 18.4 18 4 failure of atrioventricular cushion closure 0.0778270837834116 0.234164528527763 1.16732855589821 0.714285714285714 18.4 18 4 maxilla hypoplasia 0.0778270837834116 0.234164528527763 1.16732855589821 0.714285714285714 18.4 18 4 mammary gland hyperplasia 0.0778270837834116 0.234164528527763 1.16732855589821 0.714285714285714 18.4 18 4 abnormal oculomotor nerve morphology 0.0778270837834116 0.234164528527763 1.16732855589821 0.714285714285714 18.4 18 4 decreased Schwann cell number 0.0778270837834116 0.234164528527763 1.16732855589821 0.714285714285714 18.4 18 4 abnormal lacrimal gland morphology 0.0778270837834116 0.234164528527763 1.16732855589821 0.714285714285714 18.4 18 4 excessive tearing 0.0778270837834116 0.234164528527763 1.16732855589821 0.714285714285714 18.4 18 4 abnormal circulating alanine transaminase level 0.0778270837834116 0.234164528527763 1.16732855589821 0.714285714285714 18.4 18 4 abnormal axial mesoderm 0.0778270837834116 0.234164528527763 1.16732855589821 0.714285714285714 18.4 18 4 absent amniotic folds 0.0778270837834116 0.234164528527763 1.16732855589821 0.714285714285714 18.4 18 4 decreased activated T cell number 0.0778270837834116 0.234164528527763 1.16732855589821 0.714285714285714 18.4 18 4 abnormal brain ventricular system morphology 0.0778270837834116 0.234164528527763 1.16732855589821 0.714285714285714 18.4 18 4 decreased mortality induced by ionizing radiation 0.0778270837834116 0.234164528527763 1.16732855589821 0.714285714285714 18.4 18 4 calcinosis 0.0778270837834116 0.234164528527763 1.16732855589821 0.714285714285714 18.4 18 4 anuria 0.0778270837834116 0.234164528527763 1.16732855589821 0.714285714285714 18.4 18 4 abnormal hard palate morphology 0.0778270837834116 0.234164528527763 1.16732855589821 0.714285714285714 18.4 18 4 abnormal vestibular saccular macula morphology 0.0778270837834116 0.234164528527763 1.16732855589821 0.714285714285714 18.4 18 4 abnormal gallbladder morphology 0.0778270837834116 0.234164528527763 1.16732855589821 0.714285714285714 18.4 18 4 urolithiasis 0.0778270837834116 0.234164528527763 1.16732855589821 0.714285714285714 18.4 18 4 increased keratinocyte apoptosis 0.0778270837834116 0.234164528527763 1.16732855589821 0.714285714285714 18.4 18 4 uremia 0.0778270837834116 0.234164528527763 1.16732855589821 0.714285714285714 18.4 18 4 postaxial polydactyly 0.0778270837834116 0.234164528527763 1.16732855589821 0.714285714285714 18.4 18 4 abnormal sperm annulus morphology 0.0778270837834116 0.234164528527763 1.16732855589821 0.714285714285714 18.4 18 4 increased oligodendrocyte number 0.0778270837834116 0.234164528527763 1.16732855589821 0.714285714285714 18.4 18 4 decreased brain cholesterol level 0.0778270837834116 0.234164528527763 1.16732855589821 0.714285714285714 18.4 18 4 abnormal T wave 0.0778270837834116 0.234164528527763 1.16732855589821 0.714285714285714 18.4 18 4 thick mitral valve cusps 0.0778270837834116 0.234164528527763 1.16732855589821 0.714285714285714 18.4 18 4 altered tumor pathology 0.0778270837834116 0.234164528527763 1.16732855589821 0.714285714285714 18.4 18 4 dilated pulmonary alveolar ducts 0.0778270837834116 0.234164528527763 1.16732855589821 0.714285714285714 18.4 18 4 increased compact bone volume 0.0778270837834116 0.234164528527763 1.16732855589821 0.714285714285714 18.4 18 4 small lung lobe 0.0778270837834116 0.234164528527763 1.16732855589821 0.714285714285714 18.4 18 4 abnormal Mullerian duct topology 0.0778270837834116 0.234164528527763 1.16732855589821 0.714285714285714 18.4 18 4 fragmented Meckel's cartilage 0.0778270837834116 0.234164528527763 1.16732855589821 0.714285714285714 18.4 18 4 decreased collagen level 0.0778270837834116 0.234164528527763 1.16732855589821 0.714285714285714 18.4 18 4 abnormal hepatocyte morphology 1.23275233316764e-12 8.28776061825544e-11 1.16312196650759 0.711711711711712 18.4 18 4 decreased neuron apoptosis 3.56738621703291e-05 0.000507078469421106 1.16118472139348 0.710526315789474 18.4 18 4 increased tumor incidence 8.57642624228877e-14 6.88189041215914e-12 1.15979740392467 0.709677419354839 18.4 18 4 prenatal lethality 1.35947556220221e-07 3.63623167847097e-06 1.15979740392467 0.709677419354839 18.4 18 4 abnormal nervous system morphology 2.91027732825376e-09 1.07249108948611e-07 1.15846276939772 0.708860759493671 18.4 18 4 ocular hypertelorism 0.00111237512062345 0.00954342907994444 1.15760081793239 0.708333333333333 18.4 18 4 increased hemangiosarcoma incidence 0.00111237512062345 0.00954342907994444 1.15760081793239 0.708333333333333 18.4 18 4 hypopigmentation 0.00111237512062345 0.00954342907994444 1.15760081793239 0.708333333333333 18.4 18 4 decreased circulating serum albumin level 3.80614987962292e-11 2.01442506926851e-09 1.15553735836388 0.707070707070707 18.4 18 4 abnormal trophoblast layer morphology 2.30317023165532e-06 4.73482310020051e-05 1.15359527877 0.705882352941177 18.4 18 4 abnormal interatrial septum morphology 0.00651694026812893 0.0404261569001763 1.15359527877 0.705882352941177 18.4 18 4 abnormal dorsal-ventral axis patterning 0.00651694026812893 0.0404261569001763 1.15359527877 0.705882352941177 18.4 18 4 abnormal tarsal bone morphology 0.00651694026812893 0.0404261569001763 1.15359527877 0.705882352941177 18.4 18 4 coloboma 0.00651694026812893 0.0404261569001763 1.15359527877 0.705882352941177 18.4 18 4 renal interstitial fibrosis 1.2407212436986e-05 0.000212391794196151 1.15141043922687 0.704545454545455 18.4 18 4 abnormal amino acid level 1.2407212436986e-05 0.000212391794196151 1.15141043922687 0.704545454545455 18.4 18 4 abnormal heart valve morphology 0.000643447824332788 0.00607429397733515 1.15003479951453 0.703703703703704 18.4 18 4 thin epidermis 0.000643447824332788 0.00607429397733515 1.15003479951453 0.703703703703704 18.4 18 4 abnormal fetal cardiomyocyte proliferation 0.000643447824332788 0.00607429397733515 1.15003479951453 0.703703703703704 18.4 18 4 abnormal eye muscle morphology 0.000643447824332788 0.00607429397733515 1.15003479951453 0.703703703703704 18.4 18 4 perinatal lethality, incomplete penetrance 4.24590641241522e-23 1.26604134110325e-20 1.14976697585372 0.70353982300885 18.4 18 4 increased erythroid progenitor cell number 6.75496736322976e-05 0.000870620793576893 1.1483989036404 0.702702702702703 18.4 18 4 cleft secondary palate 2.2308590579057e-10 9.99867010187465e-09 1.14745913367015 0.702127659574468 18.4 18 4 abnormal brain morphology 1.01384881581512e-16 1.17299950201866e-14 1.14702718970868 0.701863354037267 18.4 18 4 prenatal lethality, incomplete penetrance 4.7364606379219e-30 1.81260705182011e-27 1.14505715581857 0.700657894736842 18.4 18 4 short stride length 4.3246100086868e-06 8.27497492046802e-05 1.14398198478025 0.7 18.4 18 4 decreased circulating phosphate level 3.96310945402598e-05 0.000555393507993782 1.14398198478025 0.7 18.4 18 4 abnormal pericardium morphology 0.00369577642911284 0.0256079216362624 1.14398198478025 0.7 18.4 18 4 increased urine glucose level 0.00369577642911284 0.0256079216362624 1.14398198478025 0.7 18.4 18 4 abnormal hair texture 0.00369577642911284 0.0256079216362624 1.14398198478025 0.7 18.4 18 4 absent placental labyrinth 0.00369577642911284 0.0256079216362624 1.14398198478025 0.7 18.4 18 4 abnormal sperm mitochondrial sheath morphology 0.00369577642911284 0.0256079216362624 1.14398198478025 0.7 18.4 18 4 increased skin tumor incidence 0.00369577642911284 0.0256079216362624 1.14398198478025 0.7 18.4 18 4 abnormal auchene hair morphology 0.0410745732028912 0.155160213883359 1.14398198478025 0.7 18.4 18 4 increased cranium width 0.0410745732028912 0.155160213883359 1.14398198478025 0.7 18.4 18 4 jaundice 0.0410745732028912 0.155160213883359 1.14398198478025 0.7 18.4 18 4 abnormal immune cell physiology 0.0410745732028912 0.155160213883359 1.14398198478025 0.7 18.4 18 4 decreased incidence of induced tumors 0.0410745732028912 0.155160213883359 1.14398198478025 0.7 18.4 18 4 absent seminal vesicle 0.0410745732028912 0.155160213883359 1.14398198478025 0.7 18.4 18 4 absent pharyngeal arches 0.0410745732028912 0.155160213883359 1.14398198478025 0.7 18.4 18 4 abnormal plasma membrane morphology 0.0410745732028912 0.155160213883359 1.14398198478025 0.7 18.4 18 4 absent coat pigmentation 0.0410745732028912 0.155160213883359 1.14398198478025 0.7 18.4 18 4 ascites 0.0410745732028912 0.155160213883359 1.14398198478025 0.7 18.4 18 4 tachypnea 0.0410745732028912 0.155160213883359 1.14398198478025 0.7 18.4 18 4 increased platelet aggregation 0.0410745732028912 0.155160213883359 1.14398198478025 0.7 18.4 18 4 protruding tongue 0.0410745732028912 0.155160213883359 1.14398198478025 0.7 18.4 18 4 abnormal cerebellar granule cell migration 0.0410745732028912 0.155160213883359 1.14398198478025 0.7 18.4 18 4 increased serotonin level 0.0410745732028912 0.155160213883359 1.14398198478025 0.7 18.4 18 4 acanthocytosis 0.0410745732028912 0.155160213883359 1.14398198478025 0.7 18.4 18 4 aorta stenosis 0.0410745732028912 0.155160213883359 1.14398198478025 0.7 18.4 18 4 abnormal left subclavian artery morphology 0.0410745732028912 0.155160213883359 1.14398198478025 0.7 18.4 18 4 abnormal inferior vena cava valve morphology 0.0410745732028912 0.155160213883359 1.14398198478025 0.7 18.4 18 4 abnormal pulmonary interalveolar septum morphology 0.0410745732028912 0.155160213883359 1.14398198478025 0.7 18.4 18 4 abnormal optic cup morphology 0.000373320397077563 0.00393489189716288 1.14398198478025 0.7 18.4 18 4 abnormal left-right axis patterning 2.32784504880767e-05 0.000358545793121305 1.14018138017965 0.697674418604651 18.4 18 4 kidney failure 2.32784504880767e-05 0.000358545793121305 1.14018138017965 0.697674418604651 18.4 18 4 belly spot 0.000217158747508308 0.00241692342025466 1.13902968181583 0.696969696969697 18.4 18 4 abnormal locomotor coordination 0.000217158747508308 0.00241692342025466 1.13902968181583 0.696969696969697 18.4 18 4 abnormal myelin sheath morphology 1.36878861743839e-05 0.000229532679141398 1.13687650661391 0.695652173913043 18.4 18 4 abnormal Wolffian duct morphology 0.00211033728518548 0.0162020493731447 1.13687650661391 0.695652173913043 18.4 18 4 abnormal palatal shelf fusion at midline 0.00211033728518548 0.0162020493731447 1.13687650661391 0.695652173913043 18.4 18 4 spleen hypoplasia 5.2727474743846e-11 2.67672639643504e-09 1.13619979440759 0.695238095238095 18.4 18 4 short snout 3.14626953522024e-11 1.72007592722205e-09 1.13490276267882 0.694444444444444 18.4 18 4 abnormal forebrain development 5.95333106567142e-08 1.73203637729329e-06 1.13490276267881 0.694444444444444 18.4 18 4 pericardial effusion 5.28709078476249e-07 1.21213256470937e-05 1.13343837201729 0.693548387096774 18.4 18 4 abnormal heart looping 7.39575715157581e-05 0.000943433123822812 1.13141075417826 0.692307692307692 18.4 18 4 failure of heart looping 7.39575715157581e-05 0.000943433123822812 1.13141075417826 0.692307692307692 18.4 18 4 distended pericardium 4.74617222416629e-06 8.91026672272728e-05 1.13141075417826 0.692307692307692 18.4 18 4 abnormal hair growth 4.74617222416629e-06 8.91026672272728e-05 1.13141075417826 0.692307692307692 18.4 18 4 thick skin 0.0012115864219488 0.0101646584303462 1.13141075417826 0.692307692307692 18.4 18 4 decreased circulating glycerol level 0.0012115864219488 0.0101646584303462 1.13141075417826 0.692307692307692 18.4 18 4 short premaxilla 0.0223460821793101 0.0996329926212788 1.13141075417826 0.692307692307692 18.4 18 4 absent common myeloid progenitor cells 0.0223460821793101 0.0996329926212788 1.13141075417826 0.692307692307692 18.4 18 4 absent trabeculae carneae 0.0223460821793101 0.0996329926212788 1.13141075417826 0.692307692307692 18.4 18 4 short hair 0.0223460821793101 0.0996329926212788 1.13141075417826 0.692307692307692 18.4 18 4 increased foot pad pigmentation 0.0223460821793101 0.0996329926212788 1.13141075417826 0.692307692307692 18.4 18 4 abnormal tail bud morphology 0.0223460821793101 0.0996329926212788 1.13141075417826 0.692307692307692 18.4 18 4 abnormal bile duct development 0.0223460821793101 0.0996329926212788 1.13141075417826 0.692307692307692 18.4 18 4 abnormal soleus morphology 0.0223460821793101 0.0996329926212788 1.13141075417826 0.692307692307692 18.4 18 4 anal atresia 0.0223460821793101 0.0996329926212788 1.13141075417826 0.692307692307692 18.4 18 4 increased cochlear inner hair cell number 0.0223460821793101 0.0996329926212788 1.13141075417826 0.692307692307692 18.4 18 4 orthokeratosis 0.0223460821793101 0.0996329926212788 1.13141075417826 0.692307692307692 18.4 18 4 empty decidua capsularis 0.0223460821793101 0.0996329926212788 1.13141075417826 0.692307692307692 18.4 18 4 abnormal joint morphology 2.79834081372544e-06 5.63633423007453e-05 1.129125075887 0.690909090909091 18.4 18 4 abnormal eye morphology 9.80641481552123e-14 7.74395455670129e-12 1.12869753894043 0.690647482014389 18.4 18 4 disheveled coat 4.3277930118688e-05 0.000599742903455356 1.12841760403494 0.69047619047619 18.4 18 4 skin edema 4.3277930118688e-05 0.000599742903455356 1.12841760403494 0.69047619047619 18.4 18 4 abnormal embryo size 2.05945691170274e-11 1.17767794663461e-09 1.12807325932818 0.690265486725664 18.4 18 4 abnormal liver physiology 3.00182955662084e-10 1.32160195081316e-08 1.12763938499767 0.69 18.4 18 4 abnormal microglial cell morphology 0.000698658253992359 0.00649686881048969 1.12707584707413 0.689655172413793 18.4 18 4 abnormal craniofacial morphology 1.78704760335238e-10 8.23200169136862e-09 1.12652872287652 0.689320388349515 18.4 18 4 abnormal intestine morphology 6.50993189439704e-08 1.85068063855001e-06 1.12631430933962 0.689189189189189 18.4 18 4 thin ventricular wall 2.61607016256297e-09 9.78567598402314e-08 1.12582354057738 0.688888888888889 18.4 18 4 trabecula carnea hypoplasia 2.53639532978777e-05 0.000384712401393114 1.12582354057738 0.688888888888889 18.4 18 4 abnormal ectoderm development 2.53639532978777e-05 0.000384712401393114 1.12582354057738 0.688888888888889 18.4 18 4 abnormal definitive hematopoiesis 1.55506743702406e-09 6.23908104773766e-08 1.12465202804817 0.688172043010753 18.4 18 4 decreased hemoglobin content 1.07177542074025e-13 8.33137924716053e-12 1.12427814107076 0.687943262411348 18.4 18 4 abnormal coat/hair pigmentation 3.77210003555344e-11 2.01442506926851e-09 1.12355373505203 0.6875 18.4 18 4 bradykinesia 0.000404344050110926 0.0042260748934913 1.12355373505203 0.6875 18.4 18 4 increased fatty acid level 0.000404344050110926 0.0042260748934913 1.12355373505203 0.6875 18.4 18 4 pancreatic islet hyperplasia 0.000404344050110926 0.0042260748934913 1.12355373505203 0.6875 18.4 18 4 abnormal hair follicle orientation 0.0123862794740374 0.0664743693455622 1.12355373505203 0.6875 18.4 18 4 disorganized retinal layers 0.0123862794740374 0.0664743693455622 1.12355373505203 0.6875 18.4 18 4 abnormal olfaction 0.0123862794740374 0.0664743693455622 1.12355373505203 0.6875 18.4 18 4 abnormal amnion morphology 0.0123862794740374 0.0664743693455622 1.12355373505203 0.6875 18.4 18 4 loose skin 0.0123862794740374 0.0664743693455622 1.12355373505203 0.6875 18.4 18 4 impaired somite development 0.0123862794740374 0.0664743693455622 1.12355373505203 0.6875 18.4 18 4 decreased liver cholesterol level 0.0123862794740374 0.0664743693455622 1.12355373505203 0.6875 18.4 18 4 abnormal pulmonary alveolus wall morphology 0.0123862794740374 0.0664743693455622 1.12355373505203 0.6875 18.4 18 4 decreased fibroblast apoptosis 0.0123862794740374 0.0664743693455622 1.12355373505203 0.6875 18.4 18 4 abnormal liver morphology 6.54487070103559e-17 8.34890557375694e-15 1.12298311355124 0.687150837988827 18.4 18 4 prenatal lethality, complete penetrance 1.98217004104798e-25 6.57419730280913e-23 1.12281890592511 0.68705035971223 18.4 18 4 decreased white adipose tissue amount 3.40537094167231e-07 8.10608633244963e-06 1.12202923880365 0.686567164179104 18.4 18 4 distended abdomen 8.74650952094321e-06 0.000154853682799617 1.12155096547083 0.686274509803922 18.4 18 4 abnormal gastrulation 8.74650952094321e-06 0.000154853682799617 1.12155096547083 0.686274509803922 18.4 18 4 abnormal cervical vertebrae morphology 8.74650952094321e-06 0.000154853682799617 1.12155096547083 0.686274509803922 18.4 18 4 abnormal gluconeogenesis 8.74650952094321e-06 0.000154853682799617 1.12155096547083 0.686274509803922 18.4 18 4 abnormal embryonic epiblast morphology 0.000234725478229404 0.00259085836160836 1.12063541366228 0.685714285714286 18.4 18 4 decreased bone mineralization 0.000234725478229404 0.00259085836160836 1.12063541366228 0.685714285714286 18.4 18 4 perinatal lethality, complete penetrance 1.22676325717108e-19 1.9687571627181e-17 1.12019698040185 0.685446009389671 18.4 18 4 decreased rib number 4.78481225825645e-09 1.6530861795018e-07 1.12011077161469 0.685393258426966 18.4 18 4 abnormal neural tube morphology 2.87774691650577e-15 2.75322902108004e-13 1.1197707258431 0.685185185185185 18.4 18 4 diluted coat color 5.14500070838818e-06 9.58665862330756e-05 1.1197707258431 0.685185185185185 18.4 18 4 abnormal neuronal precursor proliferation 5.14500070838818e-06 9.58665862330756e-05 1.1197707258431 0.685185185185185 18.4 18 4 abnormal craniofacial bone morphology 3.02946452023637e-06 6.05284577838392e-05 1.11817787986039 0.684210526315789 18.4 18 4 decreased brain weight 3.02946452023637e-06 6.05284577838392e-05 1.11817787986039 0.684210526315789 18.4 18 4 persistence of hyaloid vascular system 0.000136613931799897 0.00160295827996341 1.11817787986039 0.684210526315789 18.4 18 4 incomplete somite formation 0.000136613931799897 0.00160295827996341 1.11817787986039 0.684210526315789 18.4 18 4 impaired branching involved in ureteric bud morphogenesis 0.000136613931799897 0.00160295827996341 1.11817787986039 0.684210526315789 18.4 18 4 decreased total retina thickness 0.000136613931799897 0.00160295827996341 1.11817787986039 0.684210526315789 18.4 18 4 kyphoscoliosis 0.00695358302978552 0.0422910459329865 1.11817787986039 0.684210526315789 18.4 18 4 shiny skin 0.00695358302978552 0.0422910459329865 1.11817787986039 0.684210526315789 18.4 18 4 decreased tumor incidence 0.00695358302978552 0.0422910459329865 1.11817787986039 0.684210526315789 18.4 18 4 abnormal nasal septum morphology 0.00695358302978552 0.0422910459329865 1.11817787986039 0.684210526315789 18.4 18 4 abnormal digestive system development 0.00695358302978552 0.0422910459329865 1.11817787986039 0.684210526315789 18.4 18 4 increased liver adenoma incidence 0.00695358302978552 0.0422910459329865 1.11817787986039 0.684210526315789 18.4 18 4 abnormal blastocyst morphology 0.00695358302978552 0.0422910459329865 1.11817787986039 0.684210526315789 18.4 18 4 decreased circulating magnesium level 0.00695358302978552 0.0422910459329865 1.11817787986039 0.684210526315789 18.4 18 4 increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 0.00695358302978552 0.0422910459329865 1.11817787986039 0.684210526315789 18.4 18 4 shortened RR interval 0.00695358302978552 0.0422910459329865 1.11817787986039 0.684210526315789 18.4 18 4 decreased birth weight 1.68731752243324e-09 6.71552373928428e-08 1.11817787986039 0.684210526315789 18.4 18 4 polydactyly 1.00232582149608e-09 4.08735324749428e-08 1.11730018921686 0.683673469387755 18.4 18 4 abnormal placenta morphology 4.18070138199076e-08 1.25295116719301e-06 1.11708909906208 0.683544303797468 18.4 18 4 abnormal eating behavior 1.78539919354139e-06 3.70098374494518e-05 1.11674431847595 0.683333333333333 18.4 18 4 intracranial hemorrhage 1.78539919354139e-06 3.70098374494518e-05 1.11674431847595 0.683333333333333 18.4 18 4 sparse hair 2.47736454714332e-08 7.75150227801132e-07 1.11607998515146 0.682926829268293 18.4 18 4 abnormal mammary gland development 7.96889894043777e-05 0.00100622518346898 1.11607998515146 0.682926829268293 18.4 18 4 thick ventricular wall 7.96889894043777e-05 0.00100622518346898 1.11607998515146 0.682926829268293 18.4 18 4 embryonic lethality during organogenesis, incomplete penetrance 1.00370456666801e-20 1.92055008429743e-18 1.1155600721149 0.682608695652174 18.4 18 4 osteoporosis 4.65739605975569e-05 0.000638307035737867 1.11426816699375 0.681818181818182 18.4 18 4 muscular atrophy 4.65739605975569e-05 0.000638307035737867 1.11426816699375 0.681818181818182 18.4 18 4 increased body size 0.00394002285266441 0.026705195765675 1.11426816699375 0.681818181818182 18.4 18 4 abnormal vascular branching morphogenesis 0.00394002285266441 0.026705195765675 1.11426816699375 0.681818181818182 18.4 18 4 abnormal limb posture 0.00394002285266441 0.026705195765675 1.11426816699375 0.681818181818182 18.4 18 4 failure of palatal shelf elevation 0.00394002285266441 0.026705195765675 1.11426816699375 0.681818181818182 18.4 18 4 increased circulating creatine kinase level 0.00394002285266441 0.026705195765675 1.11426816699375 0.681818181818182 18.4 18 4 increased adenoma incidence 0.00394002285266441 0.026705195765675 1.11426816699375 0.681818181818182 18.4 18 4 embryonic lethality before implantation, incomplete penetrance 0.00394002285266441 0.026705195765675 1.11426816699375 0.681818181818182 18.4 18 4 decreased erythrocyte cell number 1.59177628031912e-14 1.43983399901593e-12 1.11379501702899 0.681528662420382 18.4 18 4 neuron degeneration 2.72662398344471e-05 0.000411059221746589 1.11268764477106 0.680851063829787 18.4 18 4 edema 1.19547635740659e-15 1.21377446491791e-13 1.11167684567516 0.680232558139535 18.4 18 4 ruffled hair 0.00224828568350812 0.0171027848248515 1.1112967852151 0.68 18.4 18 4 abnormal keratinocyte physiology 0.00224828568350812 0.0171027848248515 1.1112967852151 0.68 18.4 18 4 increased rib number 7.59253566269397e-08 2.07543213856607e-06 1.11045870317496 0.67948717948718 18.4 18 4 abnormal heart ventricle morphology 7.59253566269397e-08 2.07543213856607e-06 1.11045870317496 0.67948717948718 18.4 18 4 cleft palate 3.29388657217363e-12 2.07431464513466e-10 1.11029876385433 0.679389312977099 18.4 18 4 rib bifurcation 0.00129007693888646 0.010661350117874 1.1089621281033 0.678571428571429 18.4 18 4 absent corpus callosum 0.00129007693888646 0.010661350117874 1.1089621281033 0.678571428571429 18.4 18 4 hypoxia 0.00129007693888646 0.010661350117874 1.1089621281033 0.678571428571429 18.4 18 4 abnormal postnatal growth/weight/body size 0.000743580103592918 0.00685057595439772 1.10707934010991 0.67741935483871 18.4 18 4 decreased thymus weight 0.000743580103592918 0.00685057595439772 1.10707934010991 0.67741935483871 18.4 18 4 decreased double-negative T cell number 0.000743580103592918 0.00685057595439772 1.10707934010991 0.67741935483871 18.4 18 4 preaxial polydactyly 0.000743580103592918 0.00685057595439772 1.10707934010991 0.67741935483871 18.4 18 4 abnormal embryo development 2.10124375798864e-12 1.37548522315704e-10 1.10552880882125 0.676470588235294 18.4 18 4 decreased mean corpuscular hemoglobin 6.64964274793738e-07 1.48349653233132e-05 1.10552880882125 0.676470588235294 18.4 18 4 abnormal endoderm development 0.000430175853842668 0.00440861099151772 1.10552880882125 0.676470588235294 18.4 18 4 malocclusion 0.000249637942248607 0.00272955772019081 1.10422971503885 0.675675675675676 18.4 18 4 increased oxygen consumption 2.84091517352767e-08 8.83347061768759e-07 1.10217533417366 0.674418604651163 18.4 18 4 abnormal double-strand DNA break repair 8.47054236392401e-05 0.00106148484283431 1.10217533417366 0.674418604651163 18.4 18 4 abnormal cell death 4.94944920197655e-05 0.000669336986789275 1.10134911578222 0.673913043478261 18.4 18 4 embryonic lethality between implantation and placentation, complete penetrance 4.94944920197655e-05 0.000669336986789275 1.10134911578222 0.673913043478261 18.4 18 4 increased T cell derived lymphoma incidence 2.89700849748112e-05 0.000432811329578636 1.10062406698974 0.673469387755102 18.4 18 4 increased sarcoma incidence 2.89700849748112e-05 0.000432811329578636 1.10062406698974 0.673469387755102 18.4 18 4 abnormal craniofacial development 2.89700849748112e-05 0.000432811329578636 1.10062406698974 0.673469387755102 18.4 18 4 abnormal axial skeleton morphology 2.46118648732324e-07 6.06158553189757e-06 1.09667445909384 0.671052631578947 18.4 18 4 abnormal lung development 5.090674244956e-08 1.48977084521507e-06 1.0959155148315 0.670588235294118 18.4 18 4 increased grip strength 1.78478128049588e-08 5.69185055799167e-07 1.09549295245832 0.67032967032967 18.4 18 4 decreased double-positive T cell number 3.71603236840068e-09 1.33965659657923e-07 1.09495418543252 0.67 18.4 18 4 preweaning lethality, incomplete penetrance 6.22458491177586e-33 2.58060916134041e-30 1.09483431306248 0.669926650366748 18.4 18 4 thymus hypoplasia 7.55005209379368e-12 4.69518864582795e-10 1.08950665217166 0.666666666666667 18.4 18 4 kinked tail 3.92098928216199e-09 1.39335154848256e-07 1.08950665217166 0.666666666666667 18.4 18 4 impaired balance 3.92098928216199e-09 1.39335154848256e-07 1.08950665217166 0.666666666666667 18.4 18 4 microcephaly 1.26059625973948e-06 2.7149205161056e-05 1.08950665217166 0.666666666666667 18.4 18 4 decreased spleen weight 1.26059625973948e-06 2.7149205161056e-05 1.08950665217166 0.666666666666667 18.4 18 4 incomplete embryo turning 1.04917336809256e-05 0.000184439487853728 1.08950665217166 0.666666666666667 18.4 18 4 increased cell proliferation 1.78671914081425e-05 0.000288601549530872 1.08950665217166 0.666666666666667 18.4 18 4 abnormal mandible morphology 1.78671914081425e-05 0.000288601549530872 1.08950665217166 0.666666666666667 18.4 18 4 abnormal small intestine morphology 1.78671914081425e-05 0.000288601549530872 1.08950665217166 0.666666666666667 18.4 18 4 impaired limb coordination 1.78671914081425e-05 0.000288601549530872 1.08950665217166 0.666666666666667 18.4 18 4 abnormal dendritic spine morphology 3.04669735686121e-05 0.000449403588765475 1.08950665217166 0.666666666666667 18.4 18 4 curly tail 5.20279120673871e-05 0.000699564493338516 1.08950665217166 0.666666666666667 18.4 18 4 thymus atrophy 5.20279120673871e-05 0.000699564493338516 1.08950665217166 0.666666666666667 18.4 18 4 abnormal pharyngeal arch morphology 0.000450965778050875 0.004523295858474 1.08950665217166 0.666666666666667 18.4 18 4 abnormal retinal blood vessel morphology 0.000450965778050875 0.004523295858474 1.08950665217166 0.666666666666667 18.4 18 4 myeloid hyperplasia 0.000778714655316162 0.00715349984273002 1.08950665217166 0.666666666666667 18.4 18 4 abnormal brain commissure morphology 0.00234786361718083 0.0176711369069207 1.08950665217166 0.666666666666667 18.4 18 4 thick interventricular septum 0.00234786361718083 0.0176711369069207 1.08950665217166 0.666666666666667 18.4 18 4 decreased bone ossification 0.00234786361718083 0.0176711369069207 1.08950665217166 0.666666666666667 18.4 18 4 abnormal nursing 0.00410626161430954 0.0275690304064642 1.08950665217166 0.666666666666667 18.4 18 4 abnormal inner cell mass apoptosis 0.00410626161430954 0.0275690304064642 1.08950665217166 0.666666666666667 18.4 18 4 abnormal mitral valve morphology 0.0128276007441428 0.0673894599569624 1.08950665217166 0.666666666666667 18.4 18 4 abnormal phrenic nerve morphology 0.0128276007441428 0.0673894599569624 1.08950665217166 0.666666666666667 18.4 18 4 abnormal thymus cortex morphology 0.0128276007441428 0.0673894599569624 1.08950665217166 0.666666666666667 18.4 18 4 abnormal metacarpal bone morphology 0.0128276007441428 0.0673894599569624 1.08950665217166 0.666666666666667 18.4 18 4 abnormal redox activity 0.0128276007441428 0.0673894599569624 1.08950665217166 0.666666666666667 18.4 18 4 abnormal eye anterior chamber morphology 0.0128276007441428 0.0673894599569624 1.08950665217166 0.666666666666667 18.4 18 4 jerky movement 0.0128276007441428 0.0673894599569624 1.08950665217166 0.666666666666667 18.4 18 4 small thoracic cage 0.0128276007441428 0.0673894599569624 1.08950665217166 0.666666666666667 18.4 18 4 abnormal hypoglossal nerve topology 0.0128276007441428 0.0673894599569624 1.08950665217166 0.666666666666667 18.4 18 4 amyloidosis 0.0419569379505206 0.155656798138583 1.08950665217166 0.666666666666667 18.4 18 4 mesocardia 0.0419569379505206 0.155656798138583 1.08950665217166 0.666666666666667 18.4 18 4 myocarditis 0.0419569379505206 0.155656798138583 1.08950665217166 0.666666666666667 18.4 18 4 increased growth rate 0.0419569379505206 0.155656798138583 1.08950665217166 0.666666666666667 18.4 18 4 abnormal gastrocnemius morphology 0.0419569379505206 0.155656798138583 1.08950665217166 0.666666666666667 18.4 18 4 decreased circulating ketone body level 0.0419569379505206 0.155656798138583 1.08950665217166 0.666666666666667 18.4 18 4 abnormal thymus corticomedullary boundary morphology 0.0419569379505206 0.155656798138583 1.08950665217166 0.666666666666667 18.4 18 4 increased skeletal muscle glycogen level 0.0419569379505206 0.155656798138583 1.08950665217166 0.666666666666667 18.4 18 4 persistent right dorsal aorta 0.0419569379505206 0.155656798138583 1.08950665217166 0.666666666666667 18.4 18 4 prenatal growth retardation 0.0419569379505206 0.155656798138583 1.08950665217166 0.666666666666667 18.4 18 4 abnormal lens vesicle development 0.0783072211941236 0.234164528527763 1.08950665217166 0.666666666666667 18.4 18 4 multifocal hepatic necrosis 0.0783072211941236 0.234164528527763 1.08950665217166 0.666666666666667 18.4 18 4 decreased level of surface class I molecules 0.0783072211941236 0.234164528527763 1.08950665217166 0.666666666666667 18.4 18 4 abnormal vomeronasal organ morphology 0.0783072211941236 0.234164528527763 1.08950665217166 0.666666666666667 18.4 18 4 abnormal postural reflex 0.0783072211941236 0.234164528527763 1.08950665217166 0.666666666666667 18.4 18 4 genetic imprinting 0.0783072211941236 0.234164528527763 1.08950665217166 0.666666666666667 18.4 18 4 yellow coat color 0.0783072211941236 0.234164528527763 1.08950665217166 0.666666666666667 18.4 18 4 abnormal artery development 0.0783072211941236 0.234164528527763 1.08950665217166 0.666666666666667 18.4 18 4 premature bone ossification 0.0783072211941236 0.234164528527763 1.08950665217166 0.666666666666667 18.4 18 4 premature neuronal precursor differentiation 0.0783072211941236 0.234164528527763 1.08950665217166 0.666666666666667 18.4 18 4 short frontal bone 0.0783072211941236 0.234164528527763 1.08950665217166 0.666666666666667 18.4 18 4 decreased cochlear hair cell number 0.0783072211941236 0.234164528527763 1.08950665217166 0.666666666666667 18.4 18 4 abnormal gallbladder physiology 0.0783072211941236 0.234164528527763 1.08950665217166 0.666666666666667 18.4 18 4 liver hyperplasia 0.0783072211941236 0.234164528527763 1.08950665217166 0.666666666666667 18.4 18 4 decreased susceptibility to atherosclerosis 0.0783072211941236 0.234164528527763 1.08950665217166 0.666666666666667 18.4 18 4 axonal spheroids 0.0783072211941236 0.234164528527763 1.08950665217166 0.666666666666667 18.4 18 4 abnormal ventricle myocardium morphology 0.0783072211941236 0.234164528527763 1.08950665217166 0.666666666666667 18.4 18 4 shortened ST segment 0.0783072211941236 0.234164528527763 1.08950665217166 0.666666666666667 18.4 18 4 iris coloboma 0.0783072211941236 0.234164528527763 1.08950665217166 0.666666666666667 18.4 18 4 decreased effector memory CD4-positive, alpha-beta T cell number 0.0783072211941236 0.234164528527763 1.08950665217166 0.666666666666667 18.4 18 4 abnormal pulmonary alveolar system morphology 0.0783072211941236 0.234164528527763 1.08950665217166 0.666666666666667 18.4 18 4 abnormal pulmonary alveolar parenchyma morphology 0.0783072211941236 0.234164528527763 1.08950665217166 0.666666666666667 18.4 18 4 abnormal coronary sinus connection 0.0783072211941236 0.234164528527763 1.08950665217166 0.666666666666667 18.4 18 4 symmetric azygos veins 0.0783072211941236 0.234164528527763 1.08950665217166 0.666666666666667 18.4 18 4 increased endoplasmic reticulum stress 0.0783072211941236 0.234164528527763 1.08950665217166 0.666666666666667 18.4 18 4 kyphosis 9.44240451214582e-13 6.61633273914443e-11 1.08950665217166 0.666666666666667 18.4 18 4 delayed bone ossification 4.39148137271322e-07 1.03543221939565e-05 1.08950665217166 0.666666666666667 18.4 18 4 abnormal limb morphology 4.39148137271322e-07 1.03543221939565e-05 1.08950665217166 0.666666666666667 18.4 18 4 abnormal kidney development 6.16797459625185e-06 0.000112814976530709 1.08950665217166 0.666666666666667 18.4 18 4 albuminuria 8.89939751969154e-05 0.00109364065712043 1.08950665217166 0.666666666666667 18.4 18 4 small placenta 8.89939751969154e-05 0.00109364065712043 1.08950665217166 0.666666666666667 18.4 18 4 abnormal metabolism 8.89939751969154e-05 0.00109364065712043 1.08950665217166 0.666666666666667 18.4 18 4 cardiomyopathy 8.89939751969154e-05 0.00109364065712043 1.08950665217166 0.666666666666667 18.4 18 4 abnormal optic nerve morphology 0.000152511107975757 0.00176863114727131 1.08950665217166 0.666666666666667 18.4 18 4 abnormal scapula morphology 0.00722773910672813 0.0436722669858009 1.08950665217166 0.666666666666667 18.4 18 4 macrocytosis 0.0230192114163235 0.100633195778743 1.08950665217166 0.666666666666667 18.4 18 4 vagina atresia 0.0230192114163235 0.100633195778743 1.08950665217166 0.666666666666667 18.4 18 4 abnormal prostate gland morphology 0.0230192114163235 0.100633195778743 1.08950665217166 0.666666666666667 18.4 18 4 placental labyrinth hypoplasia 0.0230192114163235 0.100633195778743 1.08950665217166 0.666666666666667 18.4 18 4 abnormal lymph node B cell domain morphology 0.0230192114163235 0.100633195778743 1.08950665217166 0.666666666666667 18.4 18 4 abnormal glial cell morphology 0.0230192114163235 0.100633195778743 1.08950665217166 0.666666666666667 18.4 18 4 abnormal olfactory nerve morphology 0.0230192114163235 0.100633195778743 1.08950665217166 0.666666666666667 18.4 18 4 abnormal cerebral aqueduct morphology 0.0230192114163235 0.100633195778743 1.08950665217166 0.666666666666667 18.4 18 4 decreased thymocyte apoptosis 0.0230192114163235 0.100633195778743 1.08950665217166 0.666666666666667 18.4 18 4 herniated liver 0.0230192114163235 0.100633195778743 1.08950665217166 0.666666666666667 18.4 18 4 hemorrhage 8.62031715938672e-19 1.26135523141026e-16 1.08487045365178 0.663829787234043 18.4 18 4 decreased circulating glucose level 6.34604677092272e-22 1.50340869930193e-19 1.08364908952558 0.663082437275986 18.4 18 4 polyuria 4.59959090619982e-07 1.06929741861421e-05 1.08243193365107 0.662337662337662 18.4 18 4 abnormal skeletal muscle fiber morphology 1.31914582170945e-06 2.81663110000194e-05 1.08183407011412 0.661971830985915 18.4 18 4 reduced fertility 1.40064582680496e-11 8.29549165280318e-10 1.08166847481791 0.661870503597122 18.4 18 4 neonatal lethality, incomplete penetrance 2.51303724218586e-20 4.4651286713838e-18 1.08112583177034 0.661538461538462 18.4 18 4 extramedullary hematopoiesis 4.3054384636669e-09 1.50841946174245e-07 1.07922828752853 0.660377358490566 18.4 18 4 abnormal mesoderm development 3.17539897176979e-05 0.000461918417677039 1.07922828752853 0.660377358490566 18.4 18 4 reduced female fertility 4.69043897073518e-18 6.4819260776132e-16 1.07776627876464 0.65948275862069 18.4 18 4 abnormal astrocyte morphology 0.000158426252186494 0.00182870209890443 1.07712589476062 0.659090909090909 18.4 18 4 cardiac fibrosis 1.67607753143186e-07 4.41189720575318e-06 1.076688926852 0.658823529411765 18.4 18 4 liver fibrosis 0.000271692089828784 0.00295769835207484 1.07621998568176 0.658536585365854 18.4 18 4 hemopericardium 0.000271692089828784 0.00295769835207484 1.07621998568176 0.658536585365854 18.4 18 4 abnormal heart development 1.13780866730997e-12 7.86194183314877e-11 1.07571542872645 0.658227848101266 18.4 18 4 thick epidermis 2.32397440938072e-06 4.7579311467774e-05 1.07394227142635 0.657142857142857 18.4 18 4 thick pulmonary interalveolar septum 0.000804789073768093 0.00725777675007932 1.07394227142635 0.657142857142857 18.4 18 4 ovary cysts 0.000804789073768093 0.00725777675007932 1.07394227142635 0.657142857142857 18.4 18 4 increased circulating serum albumin level 0.000804789073768093 0.00725777675007932 1.07394227142635 0.657142857142857 18.4 18 4 abnormal midbrain development 0.000804789073768093 0.00725777675007932 1.07394227142635 0.657142857142857 18.4 18 4 retinal degeneration 3.61810158654988e-08 1.10429787687642e-06 1.07248311073148 0.65625 18.4 18 4 decreased caudal vertebrae number 6.68439097871556e-06 0.000121812619483919 1.07248311073148 0.65625 18.4 18 4 neonatal lethality 0.00139121256933127 0.0114401364172282 1.07248311073148 0.65625 18.4 18 4 abnormal heart atrium morphology 0.00139121256933127 0.0114401364172282 1.07248311073148 0.65625 18.4 18 4 abnormal spongiotrophoblast layer morphology 0.00139121256933127 0.0114401364172282 1.07248311073148 0.65625 18.4 18 4 hypoglycemia 6.10317158969032e-08 1.74530771981063e-06 1.07193396423341 0.655913978494624 18.4 18 4 decreased granulocyte number 0.00241377244018525 0.0178964499104644 1.07072205472043 0.655172413793103 18.4 18 4 focal hair loss 0.00241377244018525 0.0178964499104644 1.07072205472043 0.655172413793103 18.4 18 4 increased circulating calcium level 3.2832772091622e-05 0.000474834421964592 1.069697440314 0.654545454545455 18.4 18 4 increased circulating alkaline phosphatase level 1.22797719645855e-12 8.28776061825544e-11 1.06933060305737 0.654320987654321 18.4 18 4 infertility 7.82907257481423e-09 2.57944609666893e-07 1.0691420418507 0.654205607476635 18.4 18 4 limb grasping 5.68600428413915e-14 4.9627844409811e-12 1.06855460116836 0.653846153846154 18.4 18 4 abnormal nasal bone morphology 0.00420649539978685 0.0280204386982873 1.06855460116836 0.653846153846154 18.4 18 4 increased susceptibility to otitis media 0.00420649539978685 0.0280204386982873 1.06855460116836 0.653846153846154 18.4 18 4 heart inflammation 0.00420649539978685 0.0280204386982873 1.06855460116836 0.653846153846154 18.4 18 4 abnormal ocular fundus morphology 0.00420649539978685 0.0280204386982873 1.06855460116836 0.653846153846154 18.4 18 4 decreased body length 3.32883014174244e-20 5.71066550178228e-18 1.06763699309522 0.653284671532847 18.4 18 4 decreased circulating creatinine level 9.54308807122356e-05 0.00116364860672395 1.06727182253551 0.653061224489796 18.4 18 4 abnormal testis morphology 2.85545423438534e-09 1.06014065791545e-07 1.06582172495054 0.652173913043478 18.4 18 4 abnormal coat appearance 4.06591592436225e-06 7.91178324450463e-05 1.06582172495054 0.652173913043478 18.4 18 4 abnormal pulmonary artery morphology 0.00737068329168743 0.0440734968463281 1.06582172495054 0.652173913043478 18.4 18 4 abnormal cranial nerve morphology 0.00737068329168743 0.0440734968463281 1.06582172495054 0.652173913043478 18.4 18 4 abnormal cardiovascular development 0.00737068329168743 0.0440734968463281 1.06582172495054 0.652173913043478 18.4 18 4 abnormal vertebral artery topology 0.00737068329168743 0.0440734968463281 1.06582172495054 0.652173913043478 18.4 18 4 decreased susceptibility to hepatic steatosis 1.16869814455611e-05 0.000202587918786295 1.06356601759615 0.650793650793651 18.4 18 4 increased insulin sensitivity 4.77362575654179e-11 2.47383209779119e-09 1.06284040544019 0.65034965034965 18.4 18 4 increased erythrocyte cell number 1.9838825748046e-05 0.000316340250309387 1.06226898586737 0.65 18.4 18 4 abnormal incisor morphology 1.9838825748046e-05 0.000316340250309387 1.06226898586737 0.65 18.4 18 4 perinatal lethality 0.000478609962760027 0.0047243741363713 1.06226898586737 0.65 18.4 18 4 abnormal pancreatic beta cell morphology 0.000478609962760027 0.0047243741363713 1.06226898586737 0.65 18.4 18 4 abnormal cell proliferation 0.0130037952881777 0.0673894599569624 1.06226898586737 0.65 18.4 18 4 increased mammary adenocarcinoma incidence 0.0130037952881777 0.0673894599569624 1.06226898586737 0.65 18.4 18 4 decreased myocardial infarction size 0.0130037952881777 0.0673894599569624 1.06226898586737 0.65 18.4 18 4 kidney atrophy 0.0130037952881777 0.0673894599569624 1.06226898586737 0.65 18.4 18 4 abnormal response to tactile stimuli 0.0130037952881777 0.0673894599569624 1.06226898586737 0.65 18.4 18 4 abnormal neuron proliferation 0.0130037952881777 0.0673894599569624 1.06226898586737 0.65 18.4 18 4 abnormal heart electrocardiography waveform feature 0.0130037952881777 0.0673894599569624 1.06226898586737 0.65 18.4 18 4 decreased leukocyte cell number 1.34583611423615e-10 6.50051909546102e-09 1.06167254061983 0.64963503649635 18.4 18 4 abnormal heart morphology 8.0352441384207e-17 9.75008282649829e-15 1.06120777808928 0.649350649350649 18.4 18 4 anemia 1.73104055744841e-15 1.72238535466117e-13 1.0611071896743 0.649289099526066 18.4 18 4 abnormal hair follicle development 0.00082264793645506 0.00736092353212936 1.06006052643729 0.648648648648649 18.4 18 4 ataxia 8.15219156376328e-15 7.51058389439303e-13 1.05984186708778 0.648514851485149 18.4 18 4 decreased circulating HDL cholesterol level 6.37456940897775e-10 2.73392093186761e-08 1.05971545465134 0.6484375 18.4 18 4 abnormal blood vessel morphology 4.91224423374635e-11 2.51942423328743e-09 1.05945129624969 0.648275862068965 18.4 18 4 abnormal chondrocyte morphology 5.73349339721424e-05 0.000760643457363756 1.05924257850023 0.648148148148148 18.4 18 4 axon degeneration 5.73349339721424e-05 0.000760643457363756 1.05924257850023 0.648148148148148 18.4 18 4 postnatal lethality, incomplete penetrance 6.8918927588486e-39 3.80968516391909e-36 1.05881632394147 0.647887323943662 18.4 18 4 abnormal vagus nerve morphology 0.0231467346848697 0.100659969455618 1.0574623388725 0.647058823529412 18.4 18 4 abnormal testis development 0.0231467346848697 0.100659969455618 1.0574623388725 0.647058823529412 18.4 18 4 enhanced behavioral response to cocaine 0.0231467346848697 0.100659969455618 1.0574623388725 0.647058823529412 18.4 18 4 increased hepatoma incidence 0.0231467346848697 0.100659969455618 1.0574623388725 0.647058823529412 18.4 18 4 delayed heart development 0.0231467346848697 0.100659969455618 1.0574623388725 0.647058823529412 18.4 18 4 decreased body fat mass 0.0231467346848697 0.100659969455618 1.0574623388725 0.647058823529412 18.4 18 4 abnormal motor coordination/ balance 6.66593511247976e-08 1.88426290821516e-06 1.05649129907555 0.646464646464647 18.4 18 4 abnormal lipid homeostasis 6.54056307529065e-10 2.78113686321119e-08 1.05598337056638 0.646153846153846 18.4 18 4 oligodactyly 0.000166476340946727 0.00190395355450567 1.0554595692913 0.645833333333333 18.4 18 4 abnormal myocardium layer morphology 1.49388381237804e-06 3.12271931368939e-05 1.05502859355863 0.645569620253165 18.4 18 4 lethargy 1.88929986010672e-07 4.89545146043278e-06 1.05436127629516 0.645161290322581 18.4 18 4 abnormal nose morphology 0.00245070463005658 0.0180468961654153 1.05436127629516 0.645161290322581 18.4 18 4 abnormal retinal photoreceptor layer morphology 0.00245070463005658 0.0180468961654153 1.05436127629516 0.645161290322581 18.4 18 4 syndactyly 3.43893919126259e-05 0.000494471747876629 1.05257422328449 0.644067796610169 18.4 18 4 decreased grip strength 1.91899081685119e-15 1.87195672820288e-13 1.05219478052195 0.643835616438356 18.4 18 4 abnormal enzyme/coenzyme activity 1.87892481673022e-11 1.08693615851545e-09 1.05133922168157 0.643312101910828 18.4 18 4 decreased body size 2.55057639209197e-52 2.11485292510959e-49 1.05059570030839 0.642857142857143 18.4 18 4 hydronephrosis 9.03262969916664e-07 1.97961818296714e-05 1.05059570030839 0.642857142857143 18.4 18 4 short mandible 5.83833782162987e-05 0.000770443784154074 1.05059570030839 0.642857142857143 18.4 18 4 abnormal eye development 5.83833782162987e-05 0.000770443784154074 1.05059570030839 0.642857142857143 18.4 18 4 abnormal muscle morphology 0.000486217857164234 0.00477045480959831 1.05059570030839 0.642857142857143 18.4 18 4 spina bifida 0.000486217857164234 0.00477045480959831 1.05059570030839 0.642857142857143 18.4 18 4 small superior cervical ganglion 0.00425187963811069 0.0280204386982873 1.05059570030839 0.642857142857143 18.4 18 4 abnormal ovulation 0.00425187963811069 0.0280204386982873 1.05059570030839 0.642857142857143 18.4 18 4 failure of blastocyst to hatch from the zona pellucida 0.00425187963811069 0.0280204386982873 1.05059570030839 0.642857142857143 18.4 18 4 increased bone resorption 0.00425187963811069 0.0280204386982873 1.05059570030839 0.642857142857143 18.4 18 4 increased triglyceride level 0.00425187963811069 0.0280204386982873 1.05059570030839 0.642857142857143 18.4 18 4 abnormal blood flow velocity 0.0416972796024544 0.155656798138583 1.05059570030839 0.642857142857143 18.4 18 4 megacephaly 0.0416972796024544 0.155656798138583 1.05059570030839 0.642857142857143 18.4 18 4 translucent skin 0.0416972796024544 0.155656798138583 1.05059570030839 0.642857142857143 18.4 18 4 increased aggression towards males 0.0416972796024544 0.155656798138583 1.05059570030839 0.642857142857143 18.4 18 4 intestinal obstruction 0.0416972796024544 0.155656798138583 1.05059570030839 0.642857142857143 18.4 18 4 amyloid beta deposits 0.0416972796024544 0.155656798138583 1.05059570030839 0.642857142857143 18.4 18 4 abnormal pancreas development 0.0416972796024544 0.155656798138583 1.05059570030839 0.642857142857143 18.4 18 4 abnormal maternal decidual layer morphology 0.0416972796024544 0.155656798138583 1.05059570030839 0.642857142857143 18.4 18 4 increased pulmonary respiratory rate 0.0416972796024544 0.155656798138583 1.05059570030839 0.642857142857143 18.4 18 4 sternebra fusion 0.0416972796024544 0.155656798138583 1.05059570030839 0.642857142857143 18.4 18 4 increased stomach tumor incidence 0.0416972796024544 0.155656798138583 1.05059570030839 0.642857142857143 18.4 18 4 abnormal vertebrae morphology 2.4597375705525e-08 7.74505975537893e-07 1.04952475667912 0.642201834862385 18.4 18 4 postnatal growth retardation 4.01558968567661e-40 2.49719483578014e-37 1.0494512605477 0.642156862745098 18.4 18 4 decreased circulating LDL cholesterol level 2.06046427125469e-05 0.000324392713591521 1.04694779857121 0.640625 18.4 18 4 abnormal tooth morphology 2.06046427125469e-05 0.000324392713591521 1.04694779857121 0.640625 18.4 18 4 increased sacral vertebrae number 2.06046427125469e-05 0.000324392713591521 1.04694779857121 0.640625 18.4 18 4 abnormal muscle physiology 5.45494787945568e-07 1.24487916056385e-05 1.04666088495143 0.640449438202247 18.4 18 4 increased heart weight 4.15039753580868e-10 1.81124804742528e-08 1.04639667672602 0.640287769784173 18.4 18 4 abnormal hindlimb morphology 0.000168777875962737 0.00191705464135757 1.0459263860848 0.64 18.4 18 4 decreased oocyte number 0.000168777875962737 0.00191705464135757 1.0459263860848 0.64 18.4 18 4 diaphragmatic hernia 0.00740932993573426 0.0441983410434987 1.0459263860848 0.64 18.4 18 4 decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 0.00740932993573426 0.0441983410434987 1.0459263860848 0.64 18.4 18 4 abnormal uterus morphology 0.00143078413542163 0.0116436473450504 1.04411054166451 0.638888888888889 18.4 18 4 abnormal posture 2.60228394373443e-06 5.30588631970442e-05 1.04184073613915 0.6375 18.4 18 4 abnormal bone structure 3.40633295917785e-13 2.56765249574391e-11 1.04152319857861 0.637305699481865 18.4 18 4 decreased blood urea nitrogen level 0.000490228785201091 0.00477146969556311 1.0399836225275 0.636363636363636 18.4 18 4 embryonic lethality, incomplete penetrance 0.000490228785201091 0.00477146969556311 1.0399836225275 0.636363636363636 18.4 18 4 abnormal enterocyte morphology 0.0129812425513396 0.0673894599569624 1.0399836225275 0.636363636363636 18.4 18 4 abnormal tail movements 0.0129812425513396 0.0673894599569624 1.0399836225275 0.636363636363636 18.4 18 4 abnormal chorion morphology 0.0129812425513396 0.0673894599569624 1.0399836225275 0.636363636363636 18.4 18 4 abnormal cochlear sensory epithelium morphology 0.0129812425513396 0.0673894599569624 1.0399836225275 0.636363636363636 18.4 18 4 decreased cardiac output 0.0129812425513396 0.0673894599569624 1.0399836225275 0.636363636363636 18.4 18 4 prolonged PR interval 0.0129812425513396 0.0673894599569624 1.0399836225275 0.636363636363636 18.4 18 4 abnormal cerebral cortex pyramidal cell morphology 0.0129812425513396 0.0673894599569624 1.0399836225275 0.636363636363636 18.4 18 4 pulmonary vascular congestion 0.0129812425513396 0.0673894599569624 1.0399836225275 0.636363636363636 18.4 18 4 increased mammary gland tumor incidence 0.0129812425513396 0.0673894599569624 1.0399836225275 0.636363636363636 18.4 18 4 abnormal sphenoid bone morphology 0.0764035409553786 0.234164528527763 1.0399836225275 0.636363636363636 18.4 18 4 abnormal sebaceous gland morphology 0.0764035409553786 0.234164528527763 1.0399836225275 0.636363636363636 18.4 18 4 social withdrawal 0.0764035409553786 0.234164528527763 1.0399836225275 0.636363636363636 18.4 18 4 abnormal food preference 0.0764035409553786 0.234164528527763 1.0399836225275 0.636363636363636 18.4 18 4 abnormal hemoglobin 0.0764035409553786 0.234164528527763 1.0399836225275 0.636363636363636 18.4 18 4 impaired myelopoiesis 0.0764035409553786 0.234164528527763 1.0399836225275 0.636363636363636 18.4 18 4 abnormal proximal-distal axis patterning 0.0764035409553786 0.234164528527763 1.0399836225275 0.636363636363636 18.4 18 4 abnormal primary sex determination 0.0764035409553786 0.234164528527763 1.0399836225275 0.636363636363636 18.4 18 4 abnormal vestibular ganglion morphology 0.0764035409553786 0.234164528527763 1.0399836225275 0.636363636363636 18.4 18 4 variable body spotting 0.0764035409553786 0.234164528527763 1.0399836225275 0.636363636363636 18.4 18 4 fused joints 0.0764035409553786 0.234164528527763 1.0399836225275 0.636363636363636 18.4 18 4 dilated renal glomerular capsule 0.0764035409553786 0.234164528527763 1.0399836225275 0.636363636363636 18.4 18 4 abnormal hair medulla 0.0764035409553786 0.234164528527763 1.0399836225275 0.636363636363636 18.4 18 4 abnormal pituitary gland development 0.0764035409553786 0.234164528527763 1.0399836225275 0.636363636363636 18.4 18 4 abnormal coronal suture morphology 0.0764035409553786 0.234164528527763 1.0399836225275 0.636363636363636 18.4 18 4 abnormal crista ampullaris neuroepithelium morphology 0.0764035409553786 0.234164528527763 1.0399836225275 0.636363636363636 18.4 18 4 abnormal Bruch membrane morphology 0.0764035409553786 0.234164528527763 1.0399836225275 0.636363636363636 18.4 18 4 abnormal superovulation 0.0764035409553786 0.234164528527763 1.0399836225275 0.636363636363636 18.4 18 4 shortened PR interval 0.0764035409553786 0.234164528527763 1.0399836225275 0.636363636363636 18.4 18 4 abnormal tooth development 0.00246308391885769 0.0180468961654153 1.0399836225275 0.636363636363636 18.4 18 4 dextrocardia 0.00246308391885769 0.0180468961654153 1.0399836225275 0.636363636363636 18.4 18 4 single kidney 0.00246308391885769 0.0180468961654153 1.0399836225275 0.636363636363636 18.4 18 4 diarrhea 0.00246308391885769 0.0180468961654153 1.0399836225275 0.636363636363636 18.4 18 4 decreased total body fat amount 2.39926171733065e-21 5.4256032016909e-19 1.03731471673829 0.634730538922156 18.4 18 4 decreased bone mineral content 7.60734363784525e-14 6.41466688106443e-12 1.03712652466341 0.634615384615385 18.4 18 4 Leydig cell hyperplasia 0.000837267609174176 0.00745153194211364 1.03635998621207 0.634146341463415 18.4 18 4 lethality at weaning, incomplete penetrance 0.000837267609174176 0.00745153194211364 1.03635998621207 0.634146341463415 18.4 18 4 decreased circulating cholesterol level 2.67985331064749e-12 1.70926541288093e-10 1.03592435780256 0.633879781420765 18.4 18 4 increased circulating free fatty acid level 1.24431346447326e-05 0.000212391794196151 1.03579857776883 0.633802816901408 18.4 18 4 abnormal pulmonary alveolus morphology 2.00378948800597e-07 5.00947372001492e-06 1.03557067929188 0.633663366336634 18.4 18 4 muscular ventricular septal defect 5.95221880150817e-05 0.000779270750986925 1.03503131956308 0.633333333333333 18.4 18 4 abnormal hair cycle 0.00425234798335818 0.0280204386982873 1.03503131956308 0.633333333333333 18.4 18 4 disorganized myocardium 0.00425234798335818 0.0280204386982873 1.03503131956308 0.633333333333333 18.4 18 4 abnormal placenta labyrinth morphology 4.41825257179157e-06 8.38962081857369e-05 1.03434175839082 0.632911392405063 18.4 18 4 decreased B cell proliferation 4.41825257179157e-06 8.38962081857369e-05 1.03434175839082 0.632911392405063 18.4 18 4 increased bone marrow cell number 0.00143234415581323 0.0116436473450504 1.03216419679421 0.631578947368421 18.4 18 4 abnormal reproductive system physiology 0.00143234415581323 0.0116436473450504 1.03216419679421 0.631578947368421 18.4 18 4 abnormal triglyceride level 0.0228973453973268 0.100633195778743 1.03216419679421 0.631578947368421 18.4 18 4 small superior vagus ganglion 0.0228973453973268 0.100633195778743 1.03216419679421 0.631578947368421 18.4 18 4 flaky skin 0.0228973453973268 0.100633195778743 1.03216419679421 0.631578947368421 18.4 18 4 short vibrissae 0.0228973453973268 0.100633195778743 1.03216419679421 0.631578947368421 18.4 18 4 delayed sexual maturation 0.0228973453973268 0.100633195778743 1.03216419679421 0.631578947368421 18.4 18 4 abnormal neural crest cell migration 0.0228973453973268 0.100633195778743 1.03216419679421 0.631578947368421 18.4 18 4 decreased liver regeneration 0.0228973453973268 0.100633195778743 1.03216419679421 0.631578947368421 18.4 18 4 increased liver cholesterol level 0.0228973453973268 0.100633195778743 1.03216419679421 0.631578947368421 18.4 18 4 abnormal forelimb morphology 0.000491053765653932 0.00477146969556311 1.03029433411885 0.630434782608696 18.4 18 4 abnormal allantois morphology 0.000491053765653932 0.00477146969556311 1.03029433411885 0.630434782608696 18.4 18 4 abnormal fertility/fecundity 1.24991606564824e-05 0.000212391794196151 1.02980765753212 0.63013698630137 18.4 18 4 respiratory distress 2.08866279397807e-11 1.18080652273192e-09 1.02967825219692 0.630057803468208 18.4 18 4 enlarged liver 3.37764370842114e-07 8.10389795644155e-06 1.02958378630222 0.63 18.4 18 4 decreased heart rate 3.37764370842114e-07 8.10389795644155e-06 1.02958378630222 0.63 18.4 18 4 decreased litter size 1.41605367508099e-17 1.90401811716971e-15 1.02940931014796 0.629893238434164 18.4 18 4 abnormal rib morphology 3.38970336825089e-09 1.23093242752176e-07 1.02897850482879 0.62962962962963 18.4 18 4 abnormal myocardial fiber morphology 5.65368746989435e-07 1.27850432557838e-05 1.02773050179079 0.628865979381443 18.4 18 4 hypoactivity 7.2837977141819e-23 2.01316075711416e-20 1.02737298367911 0.628647214854111 18.4 18 4 premature death 1.47031629685458e-50 1.04497479669308e-47 1.02686951014786 0.628339140534262 18.4 18 4 increased urine protein level 7.45041853165679e-06 0.000134296493460118 1.02665049916176 0.628205128205128 18.4 18 4 microphthalmia 4.44243235474171e-10 1.92183486650783e-08 1.02541802557333 0.627450980392157 18.4 18 4 increased lung adenocarcinoma incidence 0.000288598124385493 0.00311448084342262 1.02541802557333 0.627450980392157 18.4 18 4 small lung 0.000288598124385493 0.00311448084342262 1.02541802557333 0.627450980392157 18.4 18 4 abnormal thoracic vertebrae morphology 0.000100671000822343 0.00121858449900525 1.02487490161911 0.627118644067797 18.4 18 4 increased total body fat amount 5.67161526577531e-09 1.93262232515289e-07 1.02446147890768 0.626865671641791 18.4 18 4 internal hemorrhage 3.53830365443383e-05 0.000504385692859836 1.02446147890768 0.626865671641791 18.4 18 4 spleen hyperplasia 1.25087026531603e-05 0.000212391794196151 1.02413625304136 0.626666666666667 18.4 18 4 abnormal skeleton morphology 7.28924571288388e-08 2.02592164366465e-06 1.02318885595252 0.626086956521739 18.4 18 4 hyperglycemia 2.6498209958519e-06 5.35888595705822e-05 1.02141248641093 0.625 18.4 18 4 small kidney 2.6498209958519e-06 5.35888595705822e-05 1.02141248641093 0.625 18.4 18 4 cachexia 3.38816236168812e-07 8.10389795644155e-06 1.02141248641093 0.625 18.4 18 4 abnormal neuromuscular synapse morphology 2.10017652844321e-05 0.000328565353113363 1.02141248641093 0.625 18.4 18 4 abnormal digit morphology 2.10017652844321e-05 0.000328565353113363 1.02141248641093 0.625 18.4 18 4 polydipsia 0.00421652473126543 0.0280204386982873 1.02141248641093 0.625 18.4 18 4 failure of primitive streak formation 0.00421652473126543 0.0280204386982873 1.02141248641093 0.625 18.4 18 4 abnormal depression-related behavior 0.00421652473126543 0.0280204386982873 1.02141248641093 0.625 18.4 18 4 abnormal digestive system morphology 0.0128113860873172 0.0673894599569624 1.02141248641093 0.625 18.4 18 4 curly vibrissae 0.0128113860873172 0.0673894599569624 1.02141248641093 0.625 18.4 18 4 abnormal sensory capabilities/reflexes/nociception 0.0128113860873172 0.0673894599569624 1.02141248641093 0.625 18.4 18 4 decreased fatty acid level 0.0128113860873172 0.0673894599569624 1.02141248641093 0.625 18.4 18 4 abnormal truncus arteriosus septation 0.0128113860873172 0.0673894599569624 1.02141248641093 0.625 18.4 18 4 abnormal lung saccule morphology 0.0128113860873172 0.0673894599569624 1.02141248641093 0.625 18.4 18 4 abnormal tympanic ring morphology 0.0407407646534669 0.155160213883359 1.02141248641093 0.625 18.4 18 4 abnormal bone marrow cell number 0.0407407646534669 0.155160213883359 1.02141248641093 0.625 18.4 18 4 delayed hair appearance 0.0407407646534669 0.155160213883359 1.02141248641093 0.625 18.4 18 4 abnormal mouth morphology 0.0407407646534669 0.155160213883359 1.02141248641093 0.625 18.4 18 4 reduced male mating frequency 0.0407407646534669 0.155160213883359 1.02141248641093 0.625 18.4 18 4 increased intestinal adenocarcinoma incidence 0.0407407646534669 0.155160213883359 1.02141248641093 0.625 18.4 18 4 abnormal epicardium morphology 0.0407407646534669 0.155160213883359 1.02141248641093 0.625 18.4 18 4 abnormal pulmonary elastic fiber morphology 0.0407407646534669 0.155160213883359 1.02141248641093 0.625 18.4 18 4 increased pancreatic beta cell number 0.0407407646534669 0.155160213883359 1.02141248641093 0.625 18.4 18 4 decreased aggression towards mice 0.0407407646534669 0.155160213883359 1.02141248641093 0.625 18.4 18 4 abnormal molar crown morphology 0.0407407646534669 0.155160213883359 1.02141248641093 0.625 18.4 18 4 increased cochlear outer hair cell number 0.0407407646534669 0.155160213883359 1.02141248641093 0.625 18.4 18 4 small epididymis 0.0407407646534669 0.155160213883359 1.02141248641093 0.625 18.4 18 4 decreased circulating triiodothyronine level 0.0407407646534669 0.155160213883359 1.02141248641093 0.625 18.4 18 4 decreased creatinine clearance 0.0407407646534669 0.155160213883359 1.02141248641093 0.625 18.4 18 4 dilated respiratory conducting tubes 0.0407407646534669 0.155160213883359 1.02141248641093 0.625 18.4 18 4 embryonic lethality between somite formation and embryo turning, incomplete penetrance 0.0407407646534669 0.155160213883359 1.02141248641093 0.625 18.4 18 4 schistocytosis 0.143702247301617 0.348997252621141 1.02141248641093 0.625 18.4 18 4 clubfoot 0.143702247301617 0.348997252621141 1.02141248641093 0.625 18.4 18 4 enlarged pituitary gland 0.143702247301617 0.348997252621141 1.02141248641093 0.625 18.4 18 4 abnormal vagus ganglion morphology 0.143702247301617 0.348997252621141 1.02141248641093 0.625 18.4 18 4 absent skin pigmentation 0.143702247301617 0.348997252621141 1.02141248641093 0.625 18.4 18 4 increased sensitivity to skin irradiation 0.143702247301617 0.348997252621141 1.02141248641093 0.625 18.4 18 4 dermal cysts 0.143702247301617 0.348997252621141 1.02141248641093 0.625 18.4 18 4 spinning 0.143702247301617 0.348997252621141 1.02141248641093 0.625 18.4 18 4 abnormal drinking behavior 0.143702247301617 0.348997252621141 1.02141248641093 0.625 18.4 18 4 poor grooming 0.143702247301617 0.348997252621141 1.02141248641093 0.625 18.4 18 4 abnormal urination 0.143702247301617 0.348997252621141 1.02141248641093 0.625 18.4 18 4 preneoplasia 0.143702247301617 0.348997252621141 1.02141248641093 0.625 18.4 18 4 abnormal hepatobiliary system morphology 0.143702247301617 0.348997252621141 1.02141248641093 0.625 18.4 18 4 abnormal secondary sex determination 0.143702247301617 0.348997252621141 1.02141248641093 0.625 18.4 18 4 coarse hair 0.143702247301617 0.348997252621141 1.02141248641093 0.625 18.4 18 4 head spot 0.143702247301617 0.348997252621141 1.02141248641093 0.625 18.4 18 4 short ureter 0.143702247301617 0.348997252621141 1.02141248641093 0.625 18.4 18 4 abnormal muscle precursor cell migration 0.143702247301617 0.348997252621141 1.02141248641093 0.625 18.4 18 4 abnormal cellular cholesterol metabolism 0.143702247301617 0.348997252621141 1.02141248641093 0.625 18.4 18 4 abnormal neuron apoptosis 0.143702247301617 0.348997252621141 1.02141248641093 0.625 18.4 18 4 decreased susceptibility to age related obesity 0.143702247301617 0.348997252621141 1.02141248641093 0.625 18.4 18 4 colon polyps 0.143702247301617 0.348997252621141 1.02141248641093 0.625 18.4 18 4 abnormal perineum morphology 0.143702247301617 0.348997252621141 1.02141248641093 0.625 18.4 18 4 liver failure 0.143702247301617 0.348997252621141 1.02141248641093 0.625 18.4 18 4 pulmonary interstitial fibrosis 0.143702247301617 0.348997252621141 1.02141248641093 0.625 18.4 18 4 increased left ventricle systolic pressure 0.143702247301617 0.348997252621141 1.02141248641093 0.625 18.4 18 4 abnormal forelimb zeugopod morphology 0.143702247301617 0.348997252621141 1.02141248641093 0.625 18.4 18 4 lymph node inflammation 0.143702247301617 0.348997252621141 1.02141248641093 0.625 18.4 18 4 long femur 0.143702247301617 0.348997252621141 1.02141248641093 0.625 18.4 18 4 abnormal choroid pigmentation 0.143702247301617 0.348997252621141 1.02141248641093 0.625 18.4 18 4 non-pigmented tail tip 0.143702247301617 0.348997252621141 1.02141248641093 0.625 18.4 18 4 abnormal vertebral body development 0.143702247301617 0.348997252621141 1.02141248641093 0.625 18.4 18 4 stomach epithelial hyperplasia 0.143702247301617 0.348997252621141 1.02141248641093 0.625 18.4 18 4 hypergranulosis 0.143702247301617 0.348997252621141 1.02141248641093 0.625 18.4 18 4 urinary bladder inflammation 0.143702247301617 0.348997252621141 1.02141248641093 0.625 18.4 18 4 abnormal sphingomyelin level 0.143702247301617 0.348997252621141 1.02141248641093 0.625 18.4 18 4 abnormal frontonasal prominence morphology 0.143702247301617 0.348997252621141 1.02141248641093 0.625 18.4 18 4 decreased hippocampus pyramidal cell number 0.143702247301617 0.348997252621141 1.02141248641093 0.625 18.4 18 4 abnormal lateral plate mesoderm morphology 0.143702247301617 0.348997252621141 1.02141248641093 0.625 18.4 18 4 abnormal circulating serum amyloid protein level 0.143702247301617 0.348997252621141 1.02141248641093 0.625 18.4 18 4 sinoatrial block 0.143702247301617 0.348997252621141 1.02141248641093 0.625 18.4 18 4 increased heart right ventricle size 0.143702247301617 0.348997252621141 1.02141248641093 0.625 18.4 18 4 delayed suture closure 0.143702247301617 0.348997252621141 1.02141248641093 0.625 18.4 18 4 abnormal anterior commissure pars posterior morphology 0.143702247301617 0.348997252621141 1.02141248641093 0.625 18.4 18 4 abnormal branching involved in ureteric bud morphogenesis 0.143702247301617 0.348997252621141 1.02141248641093 0.625 18.4 18 4 impaired neuron differentiation 0.143702247301617 0.348997252621141 1.02141248641093 0.625 18.4 18 4 increased circulating lactate level 0.143702247301617 0.348997252621141 1.02141248641093 0.625 18.4 18 4 increased testis apoptosis 0.143702247301617 0.348997252621141 1.02141248641093 0.625 18.4 18 4 increased mammary gland apoptosis 0.143702247301617 0.348997252621141 1.02141248641093 0.625 18.4 18 4 decreased white adipose tissue mass 0.143702247301617 0.348997252621141 1.02141248641093 0.625 18.4 18 4 decreased vascular endothelial cell proliferation 0.143702247301617 0.348997252621141 1.02141248641093 0.625 18.4 18 4 abnormal seminiferous tubule morphology 2.04777677356705e-09 7.8974336810047e-08 1.0186140960372 0.623287671232877 18.4 18 4 abnormal kidney morphology 5.82641689277488e-11 2.92792162035909e-09 1.01791050074324 0.622857142857143 18.4 18 4 decreased body weight 1.40910540811498e-69 3.50514970268601e-66 1.01778226432676 0.622778675282714 18.4 18 4 abnormal coat/ hair morphology 0.00028694485693936 0.00311013216399415 1.01755809966976 0.622641509433962 18.4 18 4 irregular heartbeat 0.000829451306800358 0.00740847441890805 1.01687287536022 0.622222222222222 18.4 18 4 abnormal vocalization 0.00242986503372384 0.0179622266608858 1.01589133783574 0.621621621621622 18.4 18 4 decreased width of hypertrophic chondrocyte zone 0.00242986503372384 0.0179622266608858 1.01589133783574 0.621621621621622 18.4 18 4 abnormal vascular development 5.92036446045947e-05 0.000777145466775352 1.01522210770541 0.621212121212121 18.4 18 4 abnormal skin morphology 5.92036446045947e-05 0.000777145466775352 1.01522210770541 0.621212121212121 18.4 18 4 abnormal glucose homeostasis 3.49264421561497e-11 1.88868532311788e-09 1.01467789858844 0.620879120879121 18.4 18 4 enlarged heart 7.92718470852546e-14 6.5510890110203e-12 1.01436826236672 0.620689655172414 18.4 18 4 abnormal enzyme/coenzyme level 0.000168720578864152 0.00191705464135757 1.01436826236672 0.620689655172414 18.4 18 4 abnormal spinal nerve morphology 0.00725969141653413 0.0436722669858009 1.01436826236672 0.620689655172414 18.4 18 4 aphagia 0.00725969141653413 0.0436722669858009 1.01436826236672 0.620689655172414 18.4 18 4 abnormal outer ear morphology 0.00725969141653413 0.0436722669858009 1.01436826236672 0.620689655172414 18.4 18 4 abnormal embryonic erythropoiesis 0.00725969141653413 0.0436722669858009 1.01436826236672 0.620689655172414 18.4 18 4 decreased circulating alkaline phosphatase level 0.000484710863825468 0.00477045480959831 1.01324118651965 0.62 18.4 18 4 cataract 7.2310492887241e-08 2.02103765232598e-06 1.01297106090341 0.619834710743802 18.4 18 4 abnormal bone mineralization 7.2310492887241e-08 2.02103765232598e-06 1.01297106090341 0.619834710743802 18.4 18 4 increased or absent threshold for auditory brainstem response 1.08139251483945e-16 1.22271085484688e-14 1.0122233083325 0.619377162629758 18.4 18 4 increased circulating aspartate transaminase level 9.93975920794749e-05 0.00120610492828143 1.01168474844512 0.619047619047619 18.4 18 4 abnormal pancreas morphology 0.00140772345619034 0.0115568056015626 1.01168474844511 0.619047619047619 18.4 18 4 small ears 0.0223898865830331 0.0996329926212788 1.01168474844511 0.619047619047619 18.4 18 4 abnormal salivary gland morphology 0.0223898865830331 0.0996329926212788 1.01168474844511 0.619047619047619 18.4 18 4 abnormal hematopoietic system physiology 0.0223898865830331 0.0996329926212788 1.01168474844511 0.619047619047619 18.4 18 4 abnormal tumor vascularization 0.0223898865830331 0.0996329926212788 1.01168474844511 0.619047619047619 18.4 18 4 complete atrioventricular septal defect 0.0223898865830331 0.0996329926212788 1.01168474844511 0.619047619047619 18.4 18 4 increased muscle cell glucose uptake 0.0223898865830331 0.0996329926212788 1.01168474844511 0.619047619047619 18.4 18 4 abnormal rostral-caudal axis patterning 0.000284054648589549 0.00308552811513757 1.010269804741 0.618181818181818 18.4 18 4 hydroencephaly 1.99594794025767e-07 5.00947372001492e-06 1.00897789961984 0.617391304347826 18.4 18 4 abnormal innervation 0.000819071926524727 0.00734213123326219 1.00837317807377 0.617021276595745 18.4 18 4 increased respiratory quotient 0.000819071926524727 0.00734213123326219 1.00837317807377 0.617021276595745 18.4 18 4 reduced male fertility 3.55306988888703e-13 2.63828696973328e-11 1.00791364297819 0.616740088105727 18.4 18 4 decreased hematocrit 5.55186328883177e-09 1.90486343875435e-07 1.00742053454229 0.616438356164384 18.4 18 4 decreased bone marrow cell number 3.46666655793513e-05 0.000495593854187565 1.00742053454229 0.616438356164384 18.4 18 4 decreased percent body fat/body weight 3.46666655793513e-05 0.000495593854187565 1.00742053454229 0.616438356164384 18.4 18 4 respiratory failure 3.32415938549149e-09 1.21600683403089e-07 1.0065309799864 0.615894039735099 18.4 18 4 increased circulating alanine transaminase level 2.05153906407818e-05 0.000324392713591521 1.00569844815846 0.615384615384615 18.4 18 4 abnormal snout morphology 0.000478266117392978 0.0047243741363713 1.00569844815846 0.615384615384615 18.4 18 4 abnormal stomach morphology 0.0125338651932501 0.0671939432504517 1.00569844815846 0.615384615384615 18.4 18 4 abnormal membranous labyrinth morphology 0.0733343071844572 0.231643287773127 1.00569844815846 0.615384615384615 18.4 18 4 absent teeth 0.0733343071844572 0.231643287773127 1.00569844815846 0.615384615384615 18.4 18 4 uterus hypoplasia 0.0733343071844572 0.231643287773127 1.00569844815846 0.615384615384615 18.4 18 4 abnormal pulmonary alveolus epithelial cell morphology 0.0733343071844572 0.231643287773127 1.00569844815846 0.615384615384615 18.4 18 4 increased synaptic depression 0.0733343071844572 0.231643287773127 1.00569844815846 0.615384615384615 18.4 18 4 abnormal telomere length 0.0733343071844572 0.231643287773127 1.00569844815846 0.615384615384615 18.4 18 4 abnormal GABAergic neuron morphology 0.0733343071844572 0.231643287773127 1.00569844815846 0.615384615384615 18.4 18 4 abnormal exocrine pancreas morphology 0.0733343071844572 0.231643287773127 1.00569844815846 0.615384615384615 18.4 18 4 increased circulating thyroxine level 0.0733343071844572 0.231643287773127 1.00569844815846 0.615384615384615 18.4 18 4 increased prostaglandin level 0.0733343071844572 0.231643287773127 1.00569844815846 0.615384615384615 18.4 18 4 decreased cardiac stroke volume 0.0733343071844572 0.231643287773127 1.00569844815846 0.615384615384615 18.4 18 4 insulin resistance 4.21063943972297e-08 1.25436713848034e-06 1.00284135029437 0.613636363636364 18.4 18 4 abnormal suckling behavior 7.20934685678144e-06 0.000130423638590864 1.00284135029437 0.613636363636364 18.4 18 4 impaired glucose tolerance 7.46182396398554e-14 6.40044383117725e-12 1.0016432124804 0.612903225806452 18.4 18 4 increased lung adenoma incidence 0.00710494995941904 0.0431062512781826 1.0016432124804 0.612903225806452 18.4 18 4 abnormal podocyte morphology 0.00710494995941904 0.0431062512781826 1.0016432124804 0.612903225806452 18.4 18 4 organ of Corti degeneration 0.000805284978099254 0.00725777675007932 1.00056733362704 0.612244897959184 18.4 18 4 absent kidney 0.000805284978099254 0.00725777675007932 1.00056733362704 0.612244897959184 18.4 18 4 abnormal respiratory system physiology 0.000805284978099254 0.00725777675007932 1.00056733362704 0.612244897959184 18.4 18 4 abnormal gait 9.90105774864646e-17 1.17280386427419e-14 0.999595909031282 0.611650485436893 18.4 18 4 abnormal behavior 3.46951152301772e-15 3.25675845792701e-13 0.999367612603503 0.611510791366906 18.4 18 4 abnormal maxilla morphology 0.00047007494620623 0.00466790989496206 0.998714431157357 0.611111111111111 18.4 18 4 abnormal apoptosis 0.00047007494620623 0.00466790989496206 0.998714431157357 0.611111111111111 18.4 18 4 abnormal cell adhesion 0.00047007494620623 0.00466790989496206 0.998714431157357 0.611111111111111 18.4 18 4 renal hypoplasia 0.00406432905465511 0.0273613491839096 0.998714431157357 0.611111111111111 18.4 18 4 short radius 0.00406432905465511 0.0273613491839096 0.998714431157357 0.611111111111111 18.4 18 4 abnormal trophoblast giant cell morphology 0.00406432905465511 0.0273613491839096 0.998714431157357 0.611111111111111 18.4 18 4 lowered ear position 0.0393625165917261 0.153470626993603 0.998714431157357 0.611111111111111 18.4 18 4 cortical renal glomerulopathies 0.0393625165917261 0.153470626993603 0.998714431157357 0.611111111111111 18.4 18 4 right pulmonary isomerism 0.0393625165917261 0.153470626993603 0.998714431157357 0.611111111111111 18.4 18 4 abnormal mammary gland morphology 0.0393625165917261 0.153470626993603 0.998714431157357 0.611111111111111 18.4 18 4 abnormal thymus medulla morphology 0.0393625165917261 0.153470626993603 0.998714431157357 0.611111111111111 18.4 18 4 increased circulating renin level 0.0393625165917261 0.153470626993603 0.998714431157357 0.611111111111111 18.4 18 4 absent inner cell mass 0.0393625165917261 0.153470626993603 0.998714431157357 0.611111111111111 18.4 18 4 abnormal neutrophil morphology 0.0393625165917261 0.153470626993603 0.998714431157357 0.611111111111111 18.4 18 4 decreased pulmonary respiratory rate 0.0393625165917261 0.153470626993603 0.998714431157357 0.611111111111111 18.4 18 4 short ulna 0.00234109982456738 0.0176711369069207 0.996499986742374 0.609756097560976 18.4 18 4 abnormal spleen morphology 6.78774346447676e-10 2.86178167252304e-08 0.995583664915484 0.609195402298851 18.4 18 4 abnormal retinal pigmentation 1.17933065405064e-05 0.00020372118069104 0.995583664915484 0.609195402298851 18.4 18 4 postnatal lethality, complete penetrance 4.47575643314205e-20 7.42229608496056e-18 0.994951023032412 0.60880829015544 18.4 18 4 abnormal locomotor behavior 6.9904694849779e-06 0.000126925495210821 0.99476694328717 0.608695652173913 18.4 18 4 abnormal carpal bone morphology 0.0217087791774653 0.0983617271474406 0.99476694328717 0.608695652173913 18.4 18 4 failure of embryo implantation 0.0217087791774653 0.0983617271474406 0.99476694328717 0.608695652173913 18.4 18 4 conjunctivitis 0.0217087791774653 0.0983617271474406 0.99476694328717 0.608695652173913 18.4 18 4 increased susceptibility to age related obesity 0.0217087791774653 0.0983617271474406 0.99476694328717 0.608695652173913 18.4 18 4 abnormal chondrocyte physiology 0.0217087791774653 0.0983617271474406 0.99476694328717 0.608695652173913 18.4 18 4 abnormal basicranium morphology 0.0217087791774653 0.0983617271474406 0.99476694328717 0.608695652173913 18.4 18 4 abnormal hepatocyte physiology 0.0217087791774653 0.0983617271474406 0.99476694328717 0.608695652173913 18.4 18 4 postnatal lethality 1.86801713777134e-09 7.31762618930111e-08 0.994338902433776 0.608433734939759 18.4 18 4 increased granulocyte number 5.60242048881261e-05 0.000747239730076213 0.993806743534962 0.608108108108108 18.4 18 4 hunched posture 3.30765793499613e-05 0.000476973861640746 0.992968088055186 0.607594936708861 18.4 18 4 abnormal seminal vesicle morphology 0.000460427638852492 0.00460890845732625 0.992229272513478 0.607142857142857 18.4 18 4 abnormal jaw morphology 0.0121791627452906 0.0661477452596297 0.992229272513478 0.607142857142857 18.4 18 4 corneal vascularization 0.0121791627452906 0.0661477452596297 0.992229272513478 0.607142857142857 18.4 18 4 abnormal neuron morphology 4.07118896601645e-06 7.91178324450463e-05 0.990460592883329 0.606060606060606 18.4 18 4 increased mean corpuscular hemoglobin 4.07118896601645e-06 7.91178324450463e-05 0.990460592883329 0.606060606060606 18.4 18 4 abnormal QRS complex 0.00691412598112353 0.0422910459329865 0.990460592883329 0.606060606060606 18.4 18 4 increased osteoblast cell number 0.00691412598112353 0.0422910459329865 0.990460592883329 0.606060606060606 18.4 18 4 abnormal middle ear ossicle morphology 0.00691412598112353 0.0422910459329865 0.990460592883329 0.606060606060606 18.4 18 4 decreased liver weight 9.31152755507204e-05 0.00113820269254259 0.989763085423552 0.605633802816901 18.4 18 4 abnormal renal glomerulus morphology 1.43680175772733e-06 3.04173989135892e-05 0.989551913440317 0.605504587155963 18.4 18 4 seizures 8.5453625731295e-07 1.88111410625307e-05 0.989157355261114 0.605263157894737 18.4 18 4 abnormal frontal bone morphology 0.00395939704652014 0.0267635873728773 0.989157355261114 0.605263157894737 18.4 18 4 abnormal retinal outer nuclear layer morphology 0.00395939704652014 0.0267635873728773 0.989157355261114 0.605263157894737 18.4 18 4 abnormal homeostasis 0.00228249095626064 0.0172837024465703 0.988157196155694 0.604651162790698 18.4 18 4 abnormal locomotor activation 1.1343432557418e-05 0.000197320199206834 0.987739547298485 0.604395604395604 18.4 18 4 cyanosis 2.26728061308416e-10 1.00711795090122e-08 0.987365403530569 0.604166666666667 18.4 18 4 glomerulosclerosis 0.00044958551411462 0.004523295858474 0.986191366189867 0.603448275862069 18.4 18 4 thrombocytosis 0.00044958551411462 0.004523295858474 0.986191366189867 0.603448275862069 18.4 18 4 neonatal lethality, complete penetrance 2.18127366111526e-22 5.71149287581495e-20 0.985573451800023 0.603070175438597 18.4 18 4 decreased lymphocyte cell number 2.90324981132446e-07 7.0802293192839e-06 0.983109518170523 0.6015625 18.4 18 4 impaired coordination 4.49107719614817e-17 5.87976553969399e-15 0.982445304848435 0.601156069364162 18.4 18 4 increased blood urea nitrogen level 6.01142083644195e-08 1.73876852681969e-06 0.980555986954496 0.6 18.4 18 4 abnormal retinal pigment epithelium morphology 5.23315441501071e-05 0.000701750490961679 0.980555986954496 0.6 18.4 18 4 increased circulating chloride level 0.00128614614950992 0.010661350117874 0.980555986954496 0.6 18.4 18 4 abnormal circulating protein level 0.00128614614950992 0.010661350117874 0.980555986954496 0.6 18.4 18 4 abnormal skin pigmentation 0.00384132522131768 0.0265424902445215 0.980555986954496 0.6 18.4 18 4 mandible hypoplasia 0.0209144703146917 0.0954582475372397 0.980555986954496 0.6 18.4 18 4 increased pre-B cell number 0.0209144703146917 0.0954582475372397 0.980555986954496 0.6 18.4 18 4 abnormal vascular regression 0.0377376705610504 0.151112116352602 0.980555986954496 0.6 18.4 18 4 small gonad 0.0377376705610504 0.151112116352602 0.980555986954496 0.6 18.4 18 4 abnormal circulating enzyme level 0.0377376705610504 0.151112116352602 0.980555986954496 0.6 18.4 18 4 abnormal fibula morphology 0.0377376705610504 0.151112116352602 0.980555986954496 0.6 18.4 18 4 abnormal heart right ventricle morphology 0.0377376705610504 0.151112116352602 0.980555986954496 0.6 18.4 18 4 abnormal postnatal subventricular zone morphology 0.0377376705610504 0.151112116352602 0.980555986954496 0.6 18.4 18 4 dilated vasculature 0.0377376705610504 0.151112116352602 0.980555986954496 0.6 18.4 18 4 decreased circulating VLDL cholesterol level 0.0377376705610504 0.151112116352602 0.980555986954496 0.6 18.4 18 4 decreased muscle cell glucose uptake 0.0377376705610504 0.151112116352602 0.980555986954496 0.6 18.4 18 4 enlarged testis 0.134156193180972 0.348997252621141 0.980555986954496 0.6 18.4 18 4 abnormal prostate gland epithelium morphology 0.134156193180972 0.348997252621141 0.980555986954496 0.6 18.4 18 4 fused cornea and lens 0.134156193180972 0.348997252621141 0.980555986954496 0.6 18.4 18 4 abnormal gland morphology 0.134156193180972 0.348997252621141 0.980555986954496 0.6 18.4 18 4 impaired social transmission of food preference 0.134156193180972 0.348997252621141 0.980555986954496 0.6 18.4 18 4 abnormal primordial germ cell migration 0.134156193180972 0.348997252621141 0.980555986954496 0.6 18.4 18 4 abnormal scala media morphology 0.134156193180972 0.348997252621141 0.980555986954496 0.6 18.4 18 4 aneurysm 0.134156193180972 0.348997252621141 0.980555986954496 0.6 18.4 18 4 intestinal edema 0.134156193180972 0.348997252621141 0.980555986954496 0.6 18.4 18 4 abnormal hypaxial muscle morphology 0.134156193180972 0.348997252621141 0.980555986954496 0.6 18.4 18 4 abnormal pillar cell morphology 0.134156193180972 0.348997252621141 0.980555986954496 0.6 18.4 18 4 abnormal hindlimb zeugopod morphology 0.134156193180972 0.348997252621141 0.980555986954496 0.6 18.4 18 4 abnormal ear physiology 0.134156193180972 0.348997252621141 0.980555986954496 0.6 18.4 18 4 abnormal gas homeostasis 0.134156193180972 0.348997252621141 0.980555986954496 0.6 18.4 18 4 abnormal placental transport 0.134156193180972 0.348997252621141 0.980555986954496 0.6 18.4 18 4 abnormal gonadal fat pad morphology 0.134156193180972 0.348997252621141 0.980555986954496 0.6 18.4 18 4 increased susceptibility to atherosclerosis 0.134156193180972 0.348997252621141 0.980555986954496 0.6 18.4 18 4 crystalluria 0.134156193180972 0.348997252621141 0.980555986954496 0.6 18.4 18 4 abnormal hippocampus neuron morphology 0.134156193180972 0.348997252621141 0.980555986954496 0.6 18.4 18 4 umbilical hernia 0.134156193180972 0.348997252621141 0.980555986954496 0.6 18.4 18 4 thin ventricle myocardium compact layer 0.134156193180972 0.348997252621141 0.980555986954496 0.6 18.4 18 4 thick aortic valve cusps 0.134156193180972 0.348997252621141 0.980555986954496 0.6 18.4 18 4 thick aortic valve 0.134156193180972 0.348997252621141 0.980555986954496 0.6 18.4 18 4 decreased trabecular bone connectivity density 0.134156193180972 0.348997252621141 0.980555986954496 0.6 18.4 18 4 increased compact bone area 0.134156193180972 0.348997252621141 0.980555986954496 0.6 18.4 18 4 decreased macrophage cytokine production 0.134156193180972 0.348997252621141 0.980555986954496 0.6 18.4 18 4 decreased insulin secretion 1.82844522968851e-05 0.000294385599278327 0.980555986954496 0.6 18.4 18 4 abnormal neurocranium morphology 8.87336917126323e-05 0.00109364065712043 0.980555986954496 0.6 18.4 18 4 epidermal hyperplasia 0.000437782029099036 0.00447220861348605 0.980555986954496 0.6 18.4 18 4 lethality at weaning, complete penetrance 0.00221718580347591 0.0169179438225347 0.980555986954496 0.6 18.4 18 4 increased carcinoma incidence 0.00669703188041584 0.041388488950396 0.980555986954496 0.6 18.4 18 4 abnormal hippocampus pyramidal cell morphology 0.00669703188041584 0.041388488950396 0.980555986954496 0.6 18.4 18 4 impaired adaptive thermogenesis 0.00669703188041584 0.041388488950396 0.980555986954496 0.6 18.4 18 4 abnormal lactation 0.0117707065662981 0.0640692179073667 0.980555986954496 0.6 18.4 18 4 emphysema 0.0117707065662981 0.0640692179073667 0.980555986954496 0.6 18.4 18 4 abnormal apical ectodermal ridge morphology 0.0697143818816508 0.230524542322751 0.980555986954496 0.6 18.4 18 4 absent egg cylinders 0.0697143818816508 0.230524542322751 0.980555986954496 0.6 18.4 18 4 abnormal cricoid cartilage morphology 0.0697143818816508 0.230524542322751 0.980555986954496 0.6 18.4 18 4 abnormal bronchus morphology 0.0697143818816508 0.230524542322751 0.980555986954496 0.6 18.4 18 4 abnormal pericyte morphology 0.0697143818816508 0.230524542322751 0.980555986954496 0.6 18.4 18 4 abnormal rostral migratory stream morphology 0.0697143818816508 0.230524542322751 0.980555986954496 0.6 18.4 18 4 absent chorion 0.0697143818816508 0.230524542322751 0.980555986954496 0.6 18.4 18 4 bicuspid aortic valve 0.0697143818816508 0.230524542322751 0.980555986954496 0.6 18.4 18 4 abnormal branching involved in lung morphogenesis 0.0697143818816508 0.230524542322751 0.980555986954496 0.6 18.4 18 4 abnormal cranium morphology 2.69907144355091e-07 6.6147194244659e-06 0.975677598959698 0.597014925373134 18.4 18 4 absent vitelline blood vessels 0.000727001808965795 0.00674782462612842 0.97482174141675 0.596491228070175 18.4 18 4 increased bone mineral content 3.61737241362289e-06 7.1414395864182e-05 0.974558702630615 0.596330275229358 18.4 18 4 absent corpus luteum 0.00124692390850494 0.0103910325708745 0.974270371653506 0.596153846153846 18.4 18 4 eyelids open at birth 0.00124692390850494 0.0103910325708745 0.974270371653506 0.596153846153846 18.4 18 4 abnormal brain wave pattern 0.00124692390850494 0.0103910325708745 0.974270371653506 0.596153846153846 18.4 18 4 pulmonary hypoplasia 0.00214688514249515 0.0164066875328931 0.973601689174677 0.595744680851064 18.4 18 4 decreased exploration in new environment 4.95107560077293e-05 0.000669336986789275 0.972773796581841 0.595238095238095 18.4 18 4 decreased circulating chloride level 0.00646154295202091 0.0402834288048922 0.971722149234185 0.594594594594595 18.4 18 4 abnormal humerus morphology 0.00646154295202091 0.0402834288048922 0.971722149234185 0.594594594594595 18.4 18 4 increased circulating insulin level 3.15209675272916e-08 9.68005021285654e-07 0.970341862090387 0.59375 18.4 18 4 enlarged spleen 1.25830397813131e-13 9.6308650633896e-12 0.970341862090387 0.59375 18.4 18 4 increased circulating follicle stimulating hormone level 0.0113264945236436 0.0623333078043439 0.970341862090387 0.59375 18.4 18 4 abnormal diaphragm morphology 0.0113264945236436 0.0623333078043439 0.970341862090387 0.59375 18.4 18 4 abnormal lumbar vertebrae morphology 0.0113264945236436 0.0623333078043439 0.970341862090387 0.59375 18.4 18 4 abnormal auditory brainstem response waveform shape 0.0113264945236436 0.0623333078043439 0.970341862090387 0.59375 18.4 18 4 abnormal atrioventricular cushion morphology 0.0200505135758436 0.0952734527600975 0.968450357485922 0.592592592592593 18.4 18 4 decreased heart weight 8.13147097126173e-05 0.0010241536223298 0.968450357485922 0.592592592592593 18.4 18 4 decreased urine osmolality 0.00207302349327838 0.0159648481099999 0.967215089172802 0.591836734693878 18.4 18 4 omphalocele 0.00357952385184631 0.0250114201726621 0.965699078061246 0.590909090909091 18.4 18 4 abnormal photoreceptor outer segment morphology 0.00357952385184631 0.0250114201726621 0.965699078061246 0.590909090909091 18.4 18 4 abnormal abdominal fat pad morphology 0.0359801501843682 0.146482198991188 0.965699078061246 0.590909090909091 18.4 18 4 intestinal inflammation 0.0359801501843682 0.146482198991188 0.965699078061246 0.590909090909091 18.4 18 4 increased skin papilloma incidence 0.0359801501843682 0.146482198991188 0.965699078061246 0.590909090909091 18.4 18 4 cleft upper lip 0.0359801501843682 0.146482198991188 0.965699078061246 0.590909090909091 18.4 18 4 male infertility 4.57583412585084e-22 1.1382387388054e-19 0.964960663106313 0.590457256461233 18.4 18 4 short tail 7.87132936819984e-05 0.000998976112418219 0.964804083549605 0.590361445783133 18.4 18 4 female infertility 2.42373499513635e-12 1.56598462348095e-10 0.964582017242205 0.590225563909774 18.4 18 4 increased double-negative T cell number 0.000679958250994853 0.0063826269786781 0.964481298643767 0.590163934426229 18.4 18 4 absent gastric milk in neonates 0.000133350075587703 0.00157956339535433 0.963794346151855 0.58974358974359 18.4 18 4 decreased B-1 B cell number 0.00621395706932177 0.0389841568976997 0.963794346151855 0.58974358974359 18.4 18 4 abnormal dendritic cell physiology 9.08128908843985e-06 0.000160210685159533 0.962227837665627 0.588785046728972 18.4 18 4 increased kidney weight 0.00199680406315636 0.0154017057584541 0.961329398974996 0.588235294117647 18.4 18 4 cochlear inner hair cell degeneration 0.00199680406315636 0.0154017057584541 0.961329398974996 0.588235294117647 18.4 18 4 decreased circulating alanine transaminase level 0.000384741607935757 0.00404670084456742 0.961329398974996 0.588235294117647 18.4 18 4 abnormal oocyte morphology 0.0108603387428613 0.0601672441489251 0.961329398974996 0.588235294117647 18.4 18 4 overexpanded pulmonary alveoli 0.0108603387428613 0.0601672441489251 0.961329398974996 0.588235294117647 18.4 18 4 abnormal nervous system development 0.0108603387428613 0.0601672441489251 0.961329398974996 0.588235294117647 18.4 18 4 abnormal skin physiology 0.0108603387428613 0.0601672441489251 0.961329398974996 0.588235294117647 18.4 18 4 abnormal adipose tissue morphology 0.0658750931800346 0.220841366961369 0.961329398974996 0.588235294117647 18.4 18 4 abnormal bone marrow cavity morphology 0.0658750931800346 0.220841366961369 0.961329398974996 0.588235294117647 18.4 18 4 nephrocalcinosis 0.0658750931800346 0.220841366961369 0.961329398974996 0.588235294117647 18.4 18 4 increased regulatory T cell number 0.0658750931800346 0.220841366961369 0.961329398974996 0.588235294117647 18.4 18 4 abnormal survival 0.0658750931800346 0.220841366961369 0.961329398974996 0.588235294117647 18.4 18 4 abnormal hair follicle morphology 0.00065559393773046 0.00616555735389232 0.959803479294083 0.587301587301587 18.4 18 4 small testis 2.07062312000632e-12 1.37351333627086e-10 0.959239552455485 0.58695652173913 18.4 18 4 decreased cardiac muscle contractility 1.47743806861253e-05 0.000243385906998256 0.95855633340103 0.586538461538462 18.4 18 4 dermatitis 0.00112000822667162 0.00954342907994444 0.958014470013013 0.586206896551724 18.4 18 4 abnormal CD8-positive, alpha-beta T cell physiology 0.0191484137943623 0.0912484278035944 0.958014470013013 0.586206896551724 18.4 18 4 polychromatophilia 0.0191484137943623 0.0912484278035944 0.958014470013013 0.586206896551724 18.4 18 4 increased circulating bilirubin level 0.00191923025405448 0.0149544089941875 0.955887911810987 0.584905660377358 18.4 18 4 decreased T cell number 1.14371925455326e-07 3.09239309315352e-06 0.954164210908102 0.583850931677019 18.4 18 4 abnormal epidermis stratum granulosum morphology 0.0103828158364808 0.0577790926023401 0.953318320650204 0.583333333333333 18.4 18 4 liver inflammation 4.69755999835593e-06 8.8860688181828e-05 0.953318320650204 0.583333333333333 18.4 18 4 abnormal urine homeostasis 4.04223229524311e-05 0.000563308282040181 0.953318320650204 0.583333333333333 18.4 18 4 hemolytic anemia 0.0341651295036725 0.139894254552075 0.953318320650204 0.583333333333333 18.4 18 4 abnormal vasodilation 0.0341651295036725 0.139894254552075 0.953318320650204 0.583333333333333 18.4 18 4 abnormal impulse conducting system conduction 0.0341651295036725 0.139894254552075 0.953318320650204 0.583333333333333 18.4 18 4 abnormal tumor morphology 0.0341651295036725 0.139894254552075 0.953318320650204 0.583333333333333 18.4 18 4 abnormal retinal ganglion layer morphology 0.0341651295036725 0.139894254552075 0.953318320650204 0.583333333333333 18.4 18 4 increased body temperature 0.0341651295036725 0.139894254552075 0.953318320650204 0.583333333333333 18.4 18 4 abnormal supraoccipital bone morphology 0.12462878516218 0.348997252621141 0.953318320650204 0.583333333333333 18.4 18 4 abnormal superior cervical ganglion morphology 0.12462878516218 0.348997252621141 0.953318320650204 0.583333333333333 18.4 18 4 abnormal glossopharyngeal nerve morphology 0.12462878516218 0.348997252621141 0.953318320650204 0.583333333333333 18.4 18 4 abnormal respiratory function 0.12462878516218 0.348997252621141 0.953318320650204 0.583333333333333 18.4 18 4 abnormal corticospinal tract morphology 0.12462878516218 0.348997252621141 0.953318320650204 0.583333333333333 18.4 18 4 increased urine phosphate level 0.12462878516218 0.348997252621141 0.953318320650204 0.583333333333333 18.4 18 4 small thyroid gland 0.12462878516218 0.348997252621141 0.953318320650204 0.583333333333333 18.4 18 4 small intestinal inflammation 0.12462878516218 0.348997252621141 0.953318320650204 0.583333333333333 18.4 18 4 impaired sperm capacitation 0.12462878516218 0.348997252621141 0.953318320650204 0.583333333333333 18.4 18 4 delayed somite formation 0.12462878516218 0.348997252621141 0.953318320650204 0.583333333333333 18.4 18 4 abnormal nucleotide metabolism 0.12462878516218 0.348997252621141 0.953318320650204 0.583333333333333 18.4 18 4 abnormal defecation 0.12462878516218 0.348997252621141 0.953318320650204 0.583333333333333 18.4 18 4 bowed ulna 0.12462878516218 0.348997252621141 0.953318320650204 0.583333333333333 18.4 18 4 abnormal B cell proliferation 0.12462878516218 0.348997252621141 0.953318320650204 0.583333333333333 18.4 18 4 abnormal patella morphology 0.12462878516218 0.348997252621141 0.953318320650204 0.583333333333333 18.4 18 4 abnormal respiratory motile cilium morphology 0.12462878516218 0.348997252621141 0.953318320650204 0.583333333333333 18.4 18 4 weight loss 3.81664384229079e-08 1.15077594638768e-06 0.952540101612939 0.582857142857143 18.4 18 4 abnormal femur morphology 0.000606324107178507 0.00576761459505367 0.951285658985705 0.582089552238806 18.4 18 4 increased sensitivity to xenobiotic induced morbidity/mortality 1.32403820043979e-05 0.00022329118804027 0.950842169167996 0.581818181818182 18.4 18 4 cardiac hypertrophy 3.890990636686e-05 0.000546827073941041 0.950538966945685 0.581632653061224 18.4 18 4 abnormal vasculogenesis 0.00570151931814797 0.0369818234782088 0.950151150149706 0.581395348837209 18.4 18 4 abnormal blood circulation 0.00570151931814797 0.0369818234782088 0.950151150149706 0.581395348837209 18.4 18 4 abnormal axon guidance 0.00570151931814797 0.0369818234782088 0.950151150149706 0.581395348837209 18.4 18 4 decreased startle reflex 7.59203847173143e-06 0.000136355203598787 0.949826312149654 0.581196581196581 18.4 18 4 abnormal angiogenesis 0.000342796840751643 0.00362927015667823 0.949637554933408 0.581081081081081 18.4 18 4 abnormal retina morphology 2.46592180766314e-09 9.29390984327584e-08 0.949427225463877 0.580952380952381 18.4 18 4 osteopetrosis 0.0182309849450537 0.0875378416928501 0.948925148665641 0.580645161290323 18.4 18 4 abnormal cranial ganglia morphology 0.0182309849450537 0.0875378416928501 0.948925148665641 0.580645161290323 18.4 18 4 abnormal neuron differentiation 1.27404649043701e-05 0.000215591200337555 0.948454451667295 0.580357142857143 18.4 18 4 increased exploration in new environment 0.000194393062908616 0.00218308236562159 0.948274308371632 0.580246913580247 18.4 18 4 testicular atrophy 0.00315966363467289 0.0224561808321395 0.947870787389346 0.58 18.4 18 4 abnormal axon extension 0.00315966363467289 0.0224561808321395 0.947870787389346 0.58 18.4 18 4 increased T cell proliferation 2.13925749036834e-05 0.000332587687955703 0.946954379924903 0.579439252336449 18.4 18 4 thrombocytopenia 8.28506604415623e-07 1.83192015865232e-05 0.946743711542272 0.579310344827586 18.4 18 4 increased susceptibility to ischemic brain injury 0.0620021269840252 0.209661527939219 0.946150513728023 0.578947368421053 18.4 18 4 osteoarthritis 0.0620021269840252 0.209661527939219 0.946150513728023 0.578947368421053 18.4 18 4 oliguria 0.0620021269840252 0.209661527939219 0.946150513728023 0.578947368421053 18.4 18 4 increased left ventricle weight 0.0620021269840252 0.209661527939219 0.946150513728023 0.578947368421053 18.4 18 4 abnormal cochlear inner hair cell morphology 0.0620021269840252 0.209661527939219 0.946150513728023 0.578947368421053 18.4 18 4 absent amnion 0.0620021269840252 0.209661527939219 0.946150513728023 0.578947368421053 18.4 18 4 increased circulating VLDL cholesterol level 0.0620021269840252 0.209661527939219 0.946150513728023 0.578947368421053 18.4 18 4 decreased susceptibility to weight gain 0.0620021269840252 0.209661527939219 0.946150513728023 0.578947368421053 18.4 18 4 thin interventricular septum 0.0620021269840252 0.209661527939219 0.946150513728023 0.578947368421053 18.4 18 4 right-sided stomach 0.0620021269840252 0.209661527939219 0.946150513728023 0.578947368421053 18.4 18 4 alopecia 6.29678877752847e-05 0.00081579490021365 0.946150513728022 0.578947368421053 18.4 18 4 abnormal osteoclast physiology 0.000989277562408502 0.00868600666547719 0.944806549930113 0.578125 18.4 18 4 abnormal cell migration 0.00544377591803734 0.0354486717175861 0.944239098548774 0.577777777777778 18.4 18 4 abnormal ovary morphology 0.000557477136022941 0.00533355529175794 0.943727593078271 0.577464788732394 18.4 18 4 atelectasis 0.000557477136022941 0.00533355529175794 0.943727593078271 0.577464788732394 18.4 18 4 corneal opacity 0.000557477136022941 0.00533355529175794 0.943727593078271 0.577464788732394 18.4 18 4 abnormal cornea morphology 0.000315271954895278 0.00337307091527744 0.942842295148554 0.576923076923077 18.4 18 4 decreased kidney weight 0.00301936791040828 0.0215514424021251 0.942842295148554 0.576923076923077 18.4 18 4 abnormal kidney cortex morphology 0.0323425682075666 0.133419798368693 0.942842295148554 0.576923076923077 18.4 18 4 abnormal Schwann cell morphology 0.0323425682075666 0.133419798368693 0.942842295148554 0.576923076923077 18.4 18 4 pulmonary edema 0.0323425682075666 0.133419798368693 0.942842295148554 0.576923076923077 18.4 18 4 decreased bone resorption 0.0323425682075666 0.133419798368693 0.942842295148554 0.576923076923077 18.4 18 4 abnormal colon morphology 0.00168598388716261 0.013616509478302 0.941776936622962 0.576271186440678 18.4 18 4 abnormal motor capabilities/coordination/movement 3.71510497083794e-06 7.30539416202321e-05 0.940937563239163 0.575757575757576 18.4 18 4 abnormal aorta morphology 0.0173147089742064 0.0854570209788461 0.940937563239163 0.575757575757576 18.4 18 4 absent vibrissae 0.0173147089742064 0.0854570209788461 0.940937563239163 0.575757575757576 18.4 18 4 increased susceptibility to weight loss 0.009423988393092 0.0533382733283648 0.939699487498059 0.575 18.4 18 4 polyphagia 0.00288084822950378 0.0209229488201187 0.938186283814487 0.574074074074074 18.4 18 4 no abnormal phenotype detected 1.16567501781656e-63 1.93307773787913e-60 0.938168840544359 0.574063400576369 18.4 18 4 increased osteoclast cell number 0.00160994096528037 0.0130235061825526 0.937690151459218 0.573770491803279 18.4 18 4 decreased neutrophil cell number 1.73585743413884e-05 0.00028407535311976 0.935858278147453 0.572649572649573 18.4 18 4 azoospermia 6.22088672634635e-07 1.40040323364584e-05 0.935331182524729 0.572327044025157 18.4 18 4 obese 0.000487113777542903 0.00477045480959831 0.933862844718568 0.571428571428571 18.4 18 4 decreased bone mineral density 1.57211917780087e-10 7.44885039005652e-09 0.933862844718568 0.571428571428571 18.4 18 4 improved glucose tolerance 3.79172193655727e-08 1.15023272160807e-06 0.933862844718568 0.571428571428571 18.4 18 4 abnormal cardiovascular system physiology 5.45750404736268e-06 0.000101310009834438 0.933862844718568 0.571428571428571 18.4 18 4 abnormal B cell differentiation 0.000156609678233787 0.00181193755630952 0.933862844718568 0.571428571428571 18.4 18 4 domed cranium 0.000863106997683197 0.00762692240403891 0.933862844718568 0.571428571428571 18.4 18 4 abnormal epidermis stratum corneum morphology 0.00493760985823867 0.0324499458979358 0.933862844718568 0.571428571428571 18.4 18 4 abnormal artery morphology 0.0164114145594552 0.0813215014275792 0.933862844718568 0.571428571428571 18.4 18 4 increased red blood cell distribution width 0.0164114145594552 0.0813215014275792 0.933862844718568 0.571428571428571 18.4 18 4 decreased bone volume 0.0164114145594552 0.0813215014275792 0.933862844718568 0.571428571428571 18.4 18 4 increased body weight 4.2149741258073e-09 1.4871983174391e-07 0.933862844718568 0.571428571428571 18.4 18 4 abnormal cartilage morphology 0.00895339496240341 0.0508483332625079 0.933862844718568 0.571428571428571 18.4 18 4 abnormal hormone level 0.0305456480165809 0.130218165280625 0.933862844718568 0.571428571428571 18.4 18 4 abnormal renal tubule epithelium morphology 0.0305456480165809 0.130218165280625 0.933862844718568 0.571428571428571 18.4 18 4 prolonged QRS complex duration 0.0305456480165809 0.130218165280625 0.933862844718568 0.571428571428571 18.4 18 4 abnormal anxiety-related response 0.05820138253174 0.198323204174936 0.933862844718568 0.571428571428571 18.4 18 4 abnormal erythrocyte physiology 0.05820138253174 0.198323204174936 0.933862844718568 0.571428571428571 18.4 18 4 abnormal bile salt homeostasis 0.05820138253174 0.198323204174936 0.933862844718568 0.571428571428571 18.4 18 4 increased bone ossification 0.05820138253174 0.198323204174936 0.933862844718568 0.571428571428571 18.4 18 4 abnormal interparietal bone morphology 0.115517010627128 0.329906502795615 0.933862844718568 0.571428571428571 18.4 18 4 abnormal vasoconstriction 0.115517010627128 0.329906502795615 0.933862844718568 0.571428571428571 18.4 18 4 abnormal kidney blood vessel morphology 0.115517010627128 0.329906502795615 0.933862844718568 0.571428571428571 18.4 18 4 abnormal pinna reflex 0.115517010627128 0.329906502795615 0.933862844718568 0.571428571428571 18.4 18 4 abnormal adrenal gland secretion 0.115517010627128 0.329906502795615 0.933862844718568 0.571428571428571 18.4 18 4 abnormal fluid regulation 0.115517010627128 0.329906502795615 0.933862844718568 0.571428571428571 18.4 18 4 absent otoliths 0.115517010627128 0.329906502795615 0.933862844718568 0.571428571428571 18.4 18 4 failure of zygotic cell division 0.115517010627128 0.329906502795615 0.933862844718568 0.571428571428571 18.4 18 4 abnormal uterus development 0.115517010627128 0.329906502795615 0.933862844718568 0.571428571428571 18.4 18 4 abnormal decidualization 0.115517010627128 0.329906502795615 0.933862844718568 0.571428571428571 18.4 18 4 abnormal viscerocranium morphology 0.115517010627128 0.329906502795615 0.933862844718568 0.571428571428571 18.4 18 4 abnormal renal reabsorbtion 0.115517010627128 0.329906502795615 0.933862844718568 0.571428571428571 18.4 18 4 increased lung compliance 0.115517010627128 0.329906502795615 0.933862844718568 0.571428571428571 18.4 18 4 pulmonary alveolar hemorrhage 0.115517010627128 0.329906502795615 0.933862844718568 0.571428571428571 18.4 18 4 increased monocyte cell number 8.51619653510606e-05 0.00106452456688826 0.931528187606771 0.57 18.4 18 4 abnormal response to infection 0.000464757514267178 0.0046429089025687 0.930907582551737 0.569620253164557 18.4 18 4 increased inflammatory response 0.00014275001348009 0.0016710148636787 0.928947777114786 0.568421052631579 18.4 18 4 lethality, incomplete penetrance 0.00849361861591327 0.0485478446616312 0.928556805828121 0.568181818181818 18.4 18 4 decreased B cell number 3.04291740456877e-08 9.40280378119853e-07 0.928196201243334 0.567961165048544 18.4 18 4 small seminiferous tubules 0.000783893431635437 0.0071557244447455 0.927552960632631 0.567567567567568 18.4 18 4 abnormal long bone metaphysis morphology 0.0155294864973345 0.0775694732171074 0.927552960632631 0.567567567567568 18.4 18 4 skin inflammation 0.0155294864973345 0.0775694732171074 0.927552960632631 0.567567567567568 18.4 18 4 abnormal heart tube morphology 0.028796184784908 0.123288312654834 0.926080654345913 0.566666666666667 18.4 18 4 increased metastatic potential 0.028796184784908 0.123288312654834 0.926080654345913 0.566666666666667 18.4 18 4 abnormal lipid level 0.000421994987156904 0.0043647090667476 0.925424325037376 0.566265060240964 18.4 18 4 abnormal placenta development 0.00445433007086975 0.0293125556912394 0.9250528178816 0.566037735849057 18.4 18 4 increased leukocyte cell number 4.15220273045991e-06 8.03782435176579e-05 0.924202194600789 0.56551724137931 18.4 18 4 abnormal nervous system physiology 4.02834597838609e-05 0.000562950034900866 0.923712161623801 0.565217391304348 18.4 18 4 dilated heart 0.0545329324933419 0.187021449868444 0.923712161623801 0.565217391304348 18.4 18 4 abnormal corneal stroma morphology 0.0545329324933419 0.187021449868444 0.923712161623801 0.565217391304348 18.4 18 4 abnormal lens development 0.0545329324933419 0.187021449868444 0.923712161623801 0.565217391304348 18.4 18 4 decreased effector memory CD8-positive, alpha-beta T cell number 0.0545329324933419 0.187021449868444 0.923712161623801 0.565217391304348 18.4 18 4 abnormal iris morphology 0.014674746693307 0.0736698938437964 0.921890244145253 0.564102564102564 18.4 18 4 abnormal circulating hormone level 0.014674746693307 0.0736698938437964 0.921890244145253 0.564102564102564 18.4 18 4 abnormal lung morphology 3.65569466652742e-05 0.000518150454871051 0.920129567590353 0.563025210084034 18.4 18 4 abnormal cardiovascular system morphology 0.00761568619796943 0.0453206206159066 0.91927123776984 0.5625 18.4 18 4 abnormal kidney physiology 0.00761568619796943 0.0453206206159066 0.91927123776984 0.5625 18.4 18 4 abnormal vertebral body morphology 0.027108186915438 0.116261405089917 0.91927123776984 0.5625 18.4 18 4 abnormal lymphatic vessel morphology 0.027108186915438 0.116261405089917 0.91927123776984 0.5625 18.4 18 4 abnormal serotonin level 0.027108186915438 0.116261405089917 0.91927123776984 0.5625 18.4 18 4 absent mandible 0.106966175460744 0.308496650966494 0.91927123776984 0.5625 18.4 18 4 failure of tooth eruption 0.106966175460744 0.308496650966494 0.91927123776984 0.5625 18.4 18 4 abnormal pituitary gland morphology 0.106966175460744 0.308496650966494 0.91927123776984 0.5625 18.4 18 4 disorganized yolk sac vascular plexus 0.106966175460744 0.308496650966494 0.91927123776984 0.5625 18.4 18 4 abnormal extraembryonic endoderm formation 0.106966175460744 0.308496650966494 0.91927123776984 0.5625 18.4 18 4 paternal imprinting 0.106966175460744 0.308496650966494 0.91927123776984 0.5625 18.4 18 4 bowed radius 0.106966175460744 0.308496650966494 0.91927123776984 0.5625 18.4 18 4 increased thymus weight 0.106966175460744 0.308496650966494 0.91927123776984 0.5625 18.4 18 4 decreased circulating growth hormone level 0.106966175460744 0.308496650966494 0.91927123776984 0.5625 18.4 18 4 abnormal thoracic cage shape 0.106966175460744 0.308496650966494 0.91927123776984 0.5625 18.4 18 4 decreased skeletal muscle weight 0.106966175460744 0.308496650966494 0.91927123776984 0.5625 18.4 18 4 increased heart left ventricle size 0.106966175460744 0.308496650966494 0.91927123776984 0.5625 18.4 18 4 decreased midbrain size 0.106966175460744 0.308496650966494 0.91927123776984 0.5625 18.4 18 4 increased circulating HDL cholesterol level 0.000111896300540805 0.00134140745829038 0.918298463973258 0.561904761904762 18.4 18 4 hyperactivity 9.43125692456038e-13 6.61633273914443e-11 0.916242791044632 0.560646900269542 18.4 18 4 abnormal tail morphology 0.00212147686376916 0.0162447584777975 0.91617604841708 0.560606060606061 18.4 18 4 increased body length 0.00720045050641324 0.0435793689408831 0.915185587824196 0.56 18.4 18 4 kidney inflammation 0.00720045050641324 0.0435793689408831 0.915185587824196 0.56 18.4 18 4 abnormal nest building behavior 0.0510296048351027 0.186945717271455 0.915185587824196 0.56 18.4 18 4 abnormal vertebrae development 0.0510296048351027 0.186945717271455 0.915185587824196 0.56 18.4 18 4 abnormal spermatogenesis 5.13564211531557e-07 1.18836369877651e-05 0.914830313915879 0.559782608695652 18.4 18 4 abnormal retinal photoreceptor morphology 0.025490244600577 0.109795642327161 0.913262929026246 0.558823529411765 18.4 18 4 impaired synaptic plasticity 0.025490244600577 0.109795642327161 0.913262929026246 0.558823529411765 18.4 18 4 abnormal vision 0.025490244600577 0.109795642327161 0.913262929026246 0.558823529411765 18.4 18 4 abnormal spleen red pulp morphology 0.025490244600577 0.109795642327161 0.913262929026246 0.558823529411765 18.4 18 4 abnormal organ of Corti morphology 0.0130610273551471 0.0675453337753191 0.912145104143717 0.558139534883721 18.4 18 4 abnormal intestinal mucosa morphology 0.0130610273551471 0.0675453337753191 0.912145104143717 0.558139534883721 18.4 18 4 dehydration 0.00190296221067047 0.0148622244867906 0.910516273600603 0.557142857142857 18.4 18 4 abnormal long bone epiphyseal plate proliferative zone 0.00642118237257728 0.040132389828608 0.907922210143052 0.555555555555556 18.4 18 4 abnormal osteoblast physiology 0.00642118237257728 0.040132389828608 0.907922210143052 0.555555555555556 18.4 18 4 abnormal trigeminal nerve morphology 0.0477076364972205 0.175292091265637 0.907922210143052 0.555555555555556 18.4 18 4 wrinkled skin 0.0477076364972205 0.175292091265637 0.907922210143052 0.555555555555556 18.4 18 4 decreased susceptibility to pharmacologically induced seizures 0.0477076364972205 0.175292091265637 0.907922210143052 0.555555555555556 18.4 18 4 abnormal palate morphology 0.0477076364972205 0.175292091265637 0.907922210143052 0.555555555555556 18.4 18 4 abnormal heart left ventricle morphology 0.0018006367469826 0.0141073508917141 0.907922210143052 0.555555555555556 18.4 18 4 abnormal autopod morphology 0.0123059219882581 0.0664743693455622 0.907922210143052 0.555555555555556 18.4 18 4 decreased osteoclast cell number 0.0123059219882581 0.0664743693455622 0.907922210143052 0.555555555555556 18.4 18 4 heart right ventricle hypertrophy 0.023947162963173 0.103721223524137 0.907922210143052 0.555555555555556 18.4 18 4 abnormal limb bone morphology 0.023947162963173 0.103721223524137 0.907922210143052 0.555555555555556 18.4 18 4 abnormal stomach glandular epithelium morphology 0.09901581391542 0.288747757461439 0.907922210143052 0.555555555555556 18.4 18 4 thick dermal layer 0.09901581391542 0.288747757461439 0.907922210143052 0.555555555555556 18.4 18 4 abnormal iron level 0.09901581391542 0.288747757461439 0.907922210143052 0.555555555555556 18.4 18 4 eye inflammation 0.09901581391542 0.288747757461439 0.907922210143052 0.555555555555556 18.4 18 4 abnormal white adipose tissue morphology 0.09901581391542 0.288747757461439 0.907922210143052 0.555555555555556 18.4 18 4 acidosis 0.09901581391542 0.288747757461439 0.907922210143052 0.555555555555556 18.4 18 4 decreased activity of thyroid 0.09901581391542 0.288747757461439 0.907922210143052 0.555555555555556 18.4 18 4 abnormal anterior eye segment morphology 0.09901581391542 0.288747757461439 0.907922210143052 0.555555555555556 18.4 18 4 abnormal metanephric mesenchyme morphology 0.09901581391542 0.288747757461439 0.907922210143052 0.555555555555556 18.4 18 4 abnormal head movements 0.225446029935984 0.476260721414658 0.907922210143052 0.555555555555556 18.4 18 4 absent parathyroid glands 0.225446029935984 0.476260721414658 0.907922210143052 0.555555555555556 18.4 18 4 small geniculate ganglion 0.225446029935984 0.476260721414658 0.907922210143052 0.555555555555556 18.4 18 4 wavy vibrissae 0.225446029935984 0.476260721414658 0.907922210143052 0.555555555555556 18.4 18 4 abnormal thymus lobule morphology 0.225446029935984 0.476260721414658 0.907922210143052 0.555555555555556 18.4 18 4 abnormal posterior semicircular canal morphology 0.225446029935984 0.476260721414658 0.907922210143052 0.555555555555556 18.4 18 4 polycythemia 0.225446029935984 0.476260721414658 0.907922210143052 0.555555555555556 18.4 18 4 abnormal lens capsule morphology 0.225446029935984 0.476260721414658 0.907922210143052 0.555555555555556 18.4 18 4 priapism 0.225446029935984 0.476260721414658 0.907922210143052 0.555555555555556 18.4 18 4 abnormal ovary physiology 0.225446029935984 0.476260721414658 0.907922210143052 0.555555555555556 18.4 18 4 brittle hair 0.225446029935984 0.476260721414658 0.907922210143052 0.555555555555556 18.4 18 4 decreased muscle weight 0.225446029935984 0.476260721414658 0.907922210143052 0.555555555555556 18.4 18 4 abnormal bony labyrinth 0.225446029935984 0.476260721414658 0.907922210143052 0.555555555555556 18.4 18 4 small scapula 0.225446029935984 0.476260721414658 0.907922210143052 0.555555555555556 18.4 18 4 abnormal intervertebral disk development 0.225446029935984 0.476260721414658 0.907922210143052 0.555555555555556 18.4 18 4 increased tidal volume 0.225446029935984 0.476260721414658 0.907922210143052 0.555555555555556 18.4 18 4 enhanced conditioned place preference behavior 0.225446029935984 0.476260721414658 0.907922210143052 0.555555555555556 18.4 18 4 abnormal optic chiasm morphology 0.225446029935984 0.476260721414658 0.907922210143052 0.555555555555556 18.4 18 4 abnormal retinal development 0.225446029935984 0.476260721414658 0.907922210143052 0.555555555555556 18.4 18 4 eye opacity 0.225446029935984 0.476260721414658 0.907922210143052 0.555555555555556 18.4 18 4 abnormal hippocampus granule cell morphology 0.225446029935984 0.476260721414658 0.907922210143052 0.555555555555556 18.4 18 4 abnormal telomere morphology 0.225446029935984 0.476260721414658 0.907922210143052 0.555555555555556 18.4 18 4 retropulsion 0.225446029935984 0.476260721414658 0.907922210143052 0.555555555555556 18.4 18 4 decreased airway resistance 0.225446029935984 0.476260721414658 0.907922210143052 0.555555555555556 18.4 18 4 abnormal lung lobe morphology 0.225446029935984 0.476260721414658 0.907922210143052 0.555555555555556 18.4 18 4 increased core body temperature 0.225446029935984 0.476260721414658 0.907922210143052 0.555555555555556 18.4 18 4 decreased bone trabecular spacing 0.225446029935984 0.476260721414658 0.907922210143052 0.555555555555556 18.4 18 4 decreased bone mineral density of femur 0.225446029935984 0.476260721414658 0.907922210143052 0.555555555555556 18.4 18 4 adipose tissue inflammation 0.225446029935984 0.476260721414658 0.907922210143052 0.555555555555556 18.4 18 4 circling 0.00086250039796619 0.00762692240403891 0.903649635036496 0.552941176470588 18.4 18 4 abnormal blood homeostasis 0.000128739468794201 0.0015285891581173 0.903143672194931 0.552631578947368 18.4 18 4 abnormal compact bone morphology 0.0224810954049961 0.0999494634851255 0.903143672194931 0.552631578947368 18.4 18 4 abnormal middle ear morphology 0.0445730132131573 0.164747950026343 0.901660677659307 0.551724137931034 18.4 18 4 abnormal parietal bone morphology 0.0445730132131573 0.164747950026343 0.901660677659307 0.551724137931034 18.4 18 4 short limbs 0.00081562482160823 0.00733767357595108 0.901660677659307 0.551724137931034 18.4 18 4 head bobbing 0.0210923401713475 0.0961818445027076 0.898842988041621 0.55 18.4 18 4 abnormal hearing physiology 0.0916586848343276 0.269504702748688 0.898842988041621 0.55 18.4 18 4 abnormal Peyer's patch T cell area morphology 0.0916586848343276 0.269504702748688 0.898842988041621 0.55 18.4 18 4 decreased skin tensile strength 0.0916586848343276 0.269504702748688 0.898842988041621 0.55 18.4 18 4 abnormal lens epithelium morphology 0.0916586848343276 0.269504702748688 0.898842988041621 0.55 18.4 18 4 abnormal physiological neovascularization 0.0916586848343276 0.269504702748688 0.898842988041621 0.55 18.4 18 4 abnormal optic stalk morphology 0.0916586848343276 0.269504702748688 0.898842988041621 0.55 18.4 18 4 abnormal incus morphology 0.0916586848343276 0.269504702748688 0.898842988041621 0.55 18.4 18 4 increased urine calcium level 0.0916586848343276 0.269504702748688 0.898842988041621 0.55 18.4 18 4 abnormal induced retinal neovascularization 0.0916586848343276 0.269504702748688 0.898842988041621 0.55 18.4 18 4 abnormal CD4-positive, alpha-beta T cell physiology 0.00268965814646845 0.0195629375419306 0.897692100732989 0.549295774647887 18.4 18 4 impaired hematopoiesis 0.0102535784528967 0.0576688766934636 0.897240772376663 0.549019607843137 18.4 18 4 increased spleen weight 0.000190243316026499 0.00214131334215347 0.896673616389067 0.548672566371681 18.4 18 4 abnormal T cell proliferation 0.0416253560190167 0.155656798138583 0.896207084850883 0.548387096774194 18.4 18 4 small cranium 0.0416253560190167 0.155656798138583 0.896207084850883 0.548387096774194 18.4 18 4 abnormal vibrissa morphology 0.0197799061044448 0.0940774692826126 0.894951892855294 0.547619047619048 18.4 18 4 impaired righting response 0.000649856890021722 0.00612317808306452 0.894542303888312 0.547368421052632 18.4 18 4 decreased T cell proliferation 2.46154173067345e-05 0.00037564938988038 0.894426069181466 0.547297297297297 18.4 18 4 abnormal lens morphology 8.73963704558695e-05 0.0010897166491678 0.893735925609567 0.546875 18.4 18 4 increased circulating cholesterol level 5.59205511542787e-06 0.000103038793330569 0.891414533594996 0.545454545454545 18.4 18 4 increased T cell number 0.00113865953450894 0.00958516274819282 0.891414533594996 0.545454545454545 18.4 18 4 abnormal myelopoiesis 0.0185419178422278 0.0886129118780817 0.891414533594996 0.545454545454545 18.4 18 4 abnormal long bone epiphysis morphology 0.0848668613485862 0.251167540279129 0.891414533594996 0.545454545454545 18.4 18 4 abnormal facial nerve morphology 0.0848668613485862 0.251167540279129 0.891414533594996 0.545454545454545 18.4 18 4 increased myocardial infarction size 0.0848668613485862 0.251167540279129 0.891414533594996 0.545454545454545 18.4 18 4 abnormal female reproductive system physiology 0.0848668613485862 0.251167540279129 0.891414533594996 0.545454545454545 18.4 18 4 abnormal retinal layer morphology 0.0848668613485862 0.251167540279129 0.891414533594996 0.545454545454545 18.4 18 4 abnormal circulating lipid level 0.0848668613485862 0.251167540279129 0.891414533594996 0.545454545454545 18.4 18 4 abnormal mesenteric lymph node morphology 0.0848668613485862 0.251167540279129 0.891414533594996 0.545454545454545 18.4 18 4 rough coat 0.0848668613485862 0.251167540279129 0.891414533594996 0.545454545454545 18.4 18 4 increased bone volume 0.0848668613485862 0.251167540279129 0.891414533594996 0.545454545454545 18.4 18 4 abnormal ear position 0.203459375851684 0.43837609132184 0.891414533594996 0.545454545454545 18.4 18 4 absent semicircular canals 0.203459375851684 0.43837609132184 0.891414533594996 0.545454545454545 18.4 18 4 premature suture closure 0.203459375851684 0.43837609132184 0.891414533594996 0.545454545454545 18.4 18 4 enlarged cranium 0.203459375851684 0.43837609132184 0.891414533594996 0.545454545454545 18.4 18 4 abnormal stomach epithelium morphology 0.203459375851684 0.43837609132184 0.891414533594996 0.545454545454545 18.4 18 4 abnormal hypothalamus secretion 0.203459375851684 0.43837609132184 0.891414533594996 0.545454545454545 18.4 18 4 secondary sex reversal 0.203459375851684 0.43837609132184 0.891414533594996 0.545454545454545 18.4 18 4 abnormal fear/anxiety-related behavior 0.203459375851684 0.43837609132184 0.891414533594996 0.545454545454545 18.4 18 4 abnormal larynx morphology 0.203459375851684 0.43837609132184 0.891414533594996 0.545454545454545 18.4 18 4 abnormal bronchiole morphology 0.203459375851684 0.43837609132184 0.891414533594996 0.545454545454545 18.4 18 4 retinal detachment 0.203459375851684 0.43837609132184 0.891414533594996 0.545454545454545 18.4 18 4 patent ductus arteriosus 0.203459375851684 0.43837609132184 0.891414533594996 0.545454545454545 18.4 18 4 impaired luteinization 0.203459375851684 0.43837609132184 0.891414533594996 0.545454545454545 18.4 18 4 abnormal ureter development 0.203459375851684 0.43837609132184 0.891414533594996 0.545454545454545 18.4 18 4 pathological neovascularization 0.203459375851684 0.43837609132184 0.891414533594996 0.545454545454545 18.4 18 4 cyclopia 0.203459375851684 0.43837609132184 0.891414533594996 0.545454545454545 18.4 18 4 increased circulating triiodothyronine level 0.203459375851684 0.43837609132184 0.891414533594996 0.545454545454545 18.4 18 4 abnormal aorta smooth muscle morphology 0.203459375851684 0.43837609132184 0.891414533594996 0.545454545454545 18.4 18 4 decreased palatine bone horizontal plate size 0.203459375851684 0.43837609132184 0.891414533594996 0.545454545454545 18.4 18 4 increased number of Howell-Jolly bodies 0.203459375851684 0.43837609132184 0.891414533594996 0.545454545454545 18.4 18 4 abnormal pulmonary alveolar sac morphology 0.203459375851684 0.43837609132184 0.891414533594996 0.545454545454545 18.4 18 4 decreased core body temperature 0.203459375851684 0.43837609132184 0.891414533594996 0.545454545454545 18.4 18 4 decreased embryonic cilium length 0.203459375851684 0.43837609132184 0.891414533594996 0.545454545454545 18.4 18 4 abnormal phrenic nerve innervation pattern to diaphragm 0.203459375851684 0.43837609132184 0.891414533594996 0.545454545454545 18.4 18 4 chylous ascites 0.203459375851684 0.43837609132184 0.891414533594996 0.545454545454545 18.4 18 4 thin hypoglossal nerve 0.203459375851684 0.43837609132184 0.891414533594996 0.545454545454545 18.4 18 4 decreased circulating calcium level 0.00905802575098969 0.0513253737029313 0.891414533594996 0.545454545454545 18.4 18 4 abnormal T-helper 2 physiology 0.00905802575098969 0.0513253737029313 0.891414533594996 0.545454545454545 18.4 18 4 abnormal ovarian folliculogenesis 0.0388603604449159 0.152709552301308 0.891414533594996 0.545454545454545 18.4 18 4 abnormal epidermis stratum basale morphology 0.0388603604449159 0.152709552301308 0.891414533594996 0.545454545454545 18.4 18 4 cardiovascular system phenotype 0.0388603604449159 0.152709552301308 0.891414533594996 0.545454545454545 18.4 18 4 decreased sensitivity to xenobiotic induced morbidity/mortality 0.0388603604449159 0.152709552301308 0.891414533594996 0.545454545454545 18.4 18 4 increased circulating triglyceride level 3.8054243598698e-05 0.000536316889245107 0.890389919188565 0.544827586206897 18.4 18 4 abnormal visceral yolk sac morphology 0.00212243075589314 0.0162447584777975 0.889533912216104 0.544303797468354 18.4 18 4 lung inflammation 6.96636020012604e-05 0.000895546304796564 0.889229694051871 0.544117647058823 18.4 18 4 abnormal inner ear morphology 0.0173759078649026 0.0856740749533105 0.888184770792116 0.543478260869565 18.4 18 4 increased hemoglobin content 0.00799130080168408 0.046403858352096 0.8863782932922 0.542372881355932 18.4 18 4 cochlear outer hair cell degeneration 0.00374031980040626 0.0258805160042019 0.885224154889476 0.541666666666667 18.4 18 4 abnormal intestinal epithelium morphology 0.0162790278790924 0.0809072564420427 0.885224154889476 0.541666666666667 18.4 18 4 abnormal phalanx morphology 0.0162790278790924 0.0809072564420427 0.885224154889476 0.541666666666667 18.4 18 4 abnormal malleus morphology 0.0786039723902241 0.234164528527763 0.885224154889476 0.541666666666667 18.4 18 4 abnormal foregut morphology 0.0786039723902241 0.234164528527763 0.885224154889476 0.541666666666667 18.4 18 4 abnormal adrenal gland morphology 0.0786039723902241 0.234164528527763 0.885224154889476 0.541666666666667 18.4 18 4 decreased body height 0.0786039723902241 0.234164528527763 0.885224154889476 0.541666666666667 18.4 18 4 abnormal body weight 0.0786039723902241 0.234164528527763 0.885224154889476 0.541666666666667 18.4 18 4 decreased metastatic potential 0.0786039723902241 0.234164528527763 0.885224154889476 0.541666666666667 18.4 18 4 abnormal startle reflex 0.0786039723902241 0.234164528527763 0.885224154889476 0.541666666666667 18.4 18 4 abnormal primitive streak formation 0.0786039723902241 0.234164528527763 0.885224154889476 0.541666666666667 18.4 18 4 decreased ovulation rate 0.0786039723902241 0.234164528527763 0.885224154889476 0.541666666666667 18.4 18 4 decreased IgG level 0.00040715704986636 0.00424655413644684 0.883383772031078 0.540540540540541 18.4 18 4 impaired skeletal muscle contractility 0.0338503117465125 0.139293052885773 0.883383772031078 0.540540540540541 18.4 18 4 abnormal calcium ion homeostasis 0.0338503117465125 0.139293052885773 0.883383772031078 0.540540540540541 18.4 18 4 increased trabecular bone volume 0.0338503117465125 0.139293052885773 0.883383772031078 0.540540540540541 18.4 18 4 decreased respiratory quotient 0.0152482021256787 0.0763177118463294 0.882500388259047 0.54 18.4 18 4 increased startle reflex 0.00156909926803629 0.0127137929291214 0.881398639959098 0.539325842696629 18.4 18 4 abnormal excitatory postsynaptic currents 0.00310712722073228 0.0221460715231276 0.87998614213865 0.538461538461538 18.4 18 4 small lens 0.0315885022353001 0.133419798368693 0.87998614213865 0.538461538461538 18.4 18 4 acanthosis 0.0315885022353001 0.133419798368693 0.87998614213865 0.538461538461538 18.4 18 4 small ovary 0.00147623859638107 0.0119808923605152 0.87998614213865 0.538461538461538 18.4 18 4 abnormal skin condition 0.0142802385137182 0.0718343646165296 0.87998614213865 0.538461538461538 18.4 18 4 decreased body temperature 0.0142802385137182 0.0718343646165296 0.87998614213865 0.538461538461538 18.4 18 4 abnormal xiphoid process morphology 0.072831147567228 0.231643287773127 0.87998614213865 0.538461538461538 18.4 18 4 abnormal erythrocyte osmotic lysis 0.072831147567228 0.231643287773127 0.87998614213865 0.538461538461538 18.4 18 4 abnormal renal/urinary system morphology 0.184472342802855 0.403939218945513 0.87998614213865 0.538461538461538 18.4 18 4 pup cannibalization 0.184472342802855 0.403939218945513 0.87998614213865 0.538461538461538 18.4 18 4 increased pituitary adenoma incidence 0.184472342802855 0.403939218945513 0.87998614213865 0.538461538461538 18.4 18 4 abnormal lung interstitium morphology 0.184472342802855 0.403939218945513 0.87998614213865 0.538461538461538 18.4 18 4 abnormal dopaminergic neuron morphology 0.184472342802855 0.403939218945513 0.87998614213865 0.538461538461538 18.4 18 4 abnormal afterhyperpolarization 0.184472342802855 0.403939218945513 0.87998614213865 0.538461538461538 18.4 18 4 abnormal vestibulocochlear ganglion morphology 0.184472342802855 0.403939218945513 0.87998614213865 0.538461538461538 18.4 18 4 small otic vesicle 0.184472342802855 0.403939218945513 0.87998614213865 0.538461538461538 18.4 18 4 abnormal vertebral arch development 0.184472342802855 0.403939218945513 0.87998614213865 0.538461538461538 18.4 18 4 small pituitary gland 0.184472342802855 0.403939218945513 0.87998614213865 0.538461538461538 18.4 18 4 increased renin activity 0.184472342802855 0.403939218945513 0.87998614213865 0.538461538461538 18.4 18 4 abnormal aorta tunica media morphology 0.184472342802855 0.403939218945513 0.87998614213865 0.538461538461538 18.4 18 4 maternal effect 0.00620290246024234 0.0389639390652849 0.878109839063728 0.537313432835821 18.4 18 4 decreased tumor growth/size 0.0133719089059129 0.0690095921233575 0.877658136471617 0.537037037037037 18.4 18 4 decreased platelet aggregation 0.0133719089059129 0.0690095921233575 0.877658136471617 0.537037037037037 18.4 18 4 short humerus 0.0294769312937675 0.125986025074307 0.876919988333289 0.536585365853659 18.4 18 4 increased bone trabecula number 0.0294769312937675 0.125986025074307 0.876919988333289 0.536585365853659 18.4 18 4 decreased IgM level 0.0012282204009637 0.0102868627858492 0.87609813267412 0.536082474226804 18.4 18 4 arrest of spermatogenesis 0.00257724123135623 0.0187727307847691 0.875496416923657 0.535714285714286 18.4 18 4 myoclonus 0.0675099308979586 0.225713646651441 0.875496416923657 0.535714285714286 18.4 18 4 teratozoospermia 0.00227375101791878 0.0172437672471736 0.872843397478434 0.534090909090909 18.4 18 4 abnormal long bone epiphyseal plate morphology 0.0109729982194141 0.0607237665646111 0.87160532173733 0.533333333333333 18.4 18 4 abnormal cartilage development 0.0256687702467642 0.110468972299007 0.87160532173733 0.533333333333333 18.4 18 4 abnormal response to new environment 0.0626036742740142 0.210583691354443 0.87160532173733 0.533333333333333 18.4 18 4 abnormal estrous cycle 0.0626036742740142 0.210583691354443 0.87160532173733 0.533333333333333 18.4 18 4 enhanced paired-pulse facilitation 0.0626036742740142 0.210583691354443 0.87160532173733 0.533333333333333 18.4 18 4 abnormal fat pad morphology 0.0626036742740142 0.210583691354443 0.87160532173733 0.533333333333333 18.4 18 4 abnormal fontanelle morphology 0.167862872050531 0.372487862823992 0.87160532173733 0.533333333333333 18.4 18 4 decreased hepatocyte number 0.167862872050531 0.372487862823992 0.87160532173733 0.533333333333333 18.4 18 4 abnormal enteric neuron morphology 0.167862872050531 0.372487862823992 0.87160532173733 0.533333333333333 18.4 18 4 abnormal epidermis stratum spinosum morphology 0.167862872050531 0.372487862823992 0.87160532173733 0.533333333333333 18.4 18 4 dilated ureter 0.167862872050531 0.372487862823992 0.87160532173733 0.533333333333333 18.4 18 4 abnormal ear development 0.167862872050531 0.372487862823992 0.87160532173733 0.533333333333333 18.4 18 4 abnormal Muller cell morphology 0.167862872050531 0.372487862823992 0.87160532173733 0.533333333333333 18.4 18 4 increased eosinophil cell number 0.0102718946485799 0.0576688766934636 0.869848052943505 0.532258064516129 18.4 18 4 hepatic necrosis 0.023954911724469 0.103721223524137 0.86928722247739 0.531914893617021 18.4 18 4 decreased bone trabecula number 0.023954911724469 0.103721223524137 0.86928722247739 0.531914893617021 18.4 18 4 increased circulating LDL cholesterol level 0.022356936675755 0.0996329926212788 0.867158355810098 0.530612244897959 18.4 18 4 increased fluid intake 0.022356936675755 0.0996329926212788 0.867158355810098 0.530612244897959 18.4 18 4 short maxilla 0.0539017407697974 0.187021449868444 0.865196459077496 0.529411764705882 18.4 18 4 thin skin 0.0539017407697974 0.187021449868444 0.865196459077496 0.529411764705882 18.4 18 4 increased susceptibility to weight gain 0.0539017407697974 0.187021449868444 0.865196459077496 0.529411764705882 18.4 18 4 hydroureter 0.153193643026543 0.348997252621141 0.865196459077496 0.529411764705882 18.4 18 4 enlarged sebaceous gland 0.153193643026543 0.348997252621141 0.865196459077496 0.529411764705882 18.4 18 4 decreased vasoconstriction 0.153193643026543 0.348997252621141 0.865196459077496 0.529411764705882 18.4 18 4 increased circulating magnesium level 0.153193643026543 0.348997252621141 0.865196459077496 0.529411764705882 18.4 18 4 common atrium 0.153193643026543 0.348997252621141 0.865196459077496 0.529411764705882 18.4 18 4 increased trabecular bone mass 0.153193643026543 0.348997252621141 0.865196459077496 0.529411764705882 18.4 18 4 abnormal cell cytoskeleton morphology 0.153193643026543 0.348997252621141 0.865196459077496 0.529411764705882 18.4 18 4 abnormal pancreatic islet morphology 0.0194783009671035 0.0927316242213779 0.863382630022827 0.528301886792453 18.4 18 4 abnormal spatial learning 8.39344618333729e-05 0.00105447966570967 0.862247595890457 0.52760736196319 18.4 18 4 abnormal contextual conditioning behavior 0.018183547809481 0.0875378416928501 0.861700715808496 0.527272727272727 18.4 18 4 abnormal platelet physiology 0.018183547809481 0.0875378416928501 0.861700715808496 0.527272727272727 18.4 18 4 increased sensitivity to induced morbidity/mortality 3.21353556474856e-05 0.000466103190513822 0.861539227668352 0.527173913043478 18.4 18 4 increased macrophage cell number 0.0169764880995123 0.0840378390995759 0.860136830661839 0.526315789473684 18.4 18 4 enlarged adrenal glands 0.140142132728081 0.348997252621141 0.860136830661839 0.526315789473684 18.4 18 4 unresponsive to tactile stimuli 0.140142132728081 0.348997252621141 0.860136830661839 0.526315789473684 18.4 18 4 abnormal long term depression 0.140142132728081 0.348997252621141 0.860136830661839 0.526315789473684 18.4 18 4 abnormal neurotransmitter level 0.140142132728081 0.348997252621141 0.860136830661839 0.526315789473684 18.4 18 4 maternal imprinting 0.140142132728081 0.348997252621141 0.860136830661839 0.526315789473684 18.4 18 4 abnormal optic vesicle formation 0.140142132728081 0.348997252621141 0.860136830661839 0.526315789473684 18.4 18 4 abnormal photoreceptor inner segment morphology 0.140142132728081 0.348997252621141 0.860136830661839 0.526315789473684 18.4 18 4 Leydig cell hypoplasia 0.140142132728081 0.348997252621141 0.860136830661839 0.526315789473684 18.4 18 4 decreased liver glycogen level 0.140142132728081 0.348997252621141 0.860136830661839 0.526315789473684 18.4 18 4 increased B cell proliferation 0.015851126679432 0.0790173900101947 0.858678971626819 0.525423728813559 18.4 18 4 abnormal female reproductive system morphology 0.0431895234638792 0.159871933952975 0.857986488585184 0.525 18.4 18 4 abnormal maternal nurturing 0.0148018623366855 0.0741583737411986 0.85731670990557 0.524590163934426 18.4 18 4 abnormal long bone morphology 0.0148018623366855 0.0741583737411986 0.85731670990557 0.524590163934426 18.4 18 4 abnormal spleen white pulp morphology 0.0401436590020225 0.155160213883359 0.85604094099202 0.523809523809524 18.4 18 4 abnormal cytotoxic T cell physiology 0.0401436590020225 0.155160213883359 0.85604094099202 0.523809523809524 18.4 18 4 decreased cochlear outer hair cell number 0.128461717367174 0.348997252621141 0.85604094099202 0.523809523809524 18.4 18 4 abnormal stapes morphology 0.128461717367174 0.348997252621141 0.85604094099202 0.523809523809524 18.4 18 4 increased keratinocyte proliferation 0.128461717367174 0.348997252621141 0.85604094099202 0.523809523809524 18.4 18 4 decreased vocalization 0.128461717367174 0.348997252621141 0.85604094099202 0.523809523809524 18.4 18 4 increased lymphocyte cell number 0.011266434136568 0.0622783442549175 0.852657379960431 0.521739130434783 18.4 18 4 abnormal sleep pattern 0.0347155292087951 0.141797830717369 0.852657379960431 0.521739130434783 18.4 18 4 abnormal lymphocyte physiology 0.0347155292087951 0.141797830717369 0.852657379960431 0.521739130434783 18.4 18 4 fragile skeleton 0.117958420099762 0.335338937140751 0.852657379960431 0.521739130434783 18.4 18 4 bidirectional circling 0.117958420099762 0.335338937140751 0.852657379960431 0.521739130434783 18.4 18 4 abnormal circulating insulin level 0.117958420099762 0.335338937140751 0.852657379960431 0.521739130434783 18.4 18 4 hypotension 0.117958420099762 0.335338937140751 0.852657379960431 0.521739130434783 18.4 18 4 abnormal postnatal growth 0.117958420099762 0.335338937140751 0.852657379960431 0.521739130434783 18.4 18 4 abnormal nasal cavity morphology 0.117958420099762 0.335338937140751 0.852657379960431 0.521739130434783 18.4 18 4 abnormal cochlear ganglion morphology 0.117958420099762 0.335338937140751 0.852657379960431 0.521739130434783 18.4 18 4 abnormal ulna morphology 0.117958420099762 0.335338937140751 0.852657379960431 0.521739130434783 18.4 18 4 abnormal lymph node morphology 0.0322982637303136 0.133419798368693 0.851177072009111 0.520833333333333 18.4 18 4 abnormal osteoclast morphology 0.0322982637303136 0.133419798368693 0.851177072009111 0.520833333333333 18.4 18 4 abnormal thyroid gland morphology 0.108476203908272 0.312489354049596 0.849815188693897 0.52 18.4 18 4 abnormal primitive streak morphology 0.108476203908272 0.312489354049596 0.849815188693897 0.52 18.4 18 4 cryptorchism 0.099887236411852 0.290947892944358 0.847394062800182 0.518518518518518 18.4 18 4 abnormal bone trabecula morphology 0.099887236411852 0.290947892944358 0.847394062800182 0.518518518518518 18.4 18 4 reduced long term potentiation 0.00197919008384383 0.0153133291868166 0.846313203026202 0.517857142857143 18.4 18 4 cochlear ganglion degeneration 0.0226069528572894 0.100419277200906 0.8453068853056 0.517241379310345 18.4 18 4 decreased retinal photoreceptor cell number 0.0920851998459597 0.270120205916067 0.8453068853056 0.517241379310345 18.4 18 4 stomach inflammation 0.0920851998459597 0.270120205916067 0.8453068853056 0.517241379310345 18.4 18 4 decreased bone strength 0.0920851998459597 0.270120205916067 0.8453068853056 0.517241379310345 18.4 18 4 increased retinal apoptosis 0.0920851998459597 0.270120205916067 0.8453068853056 0.517241379310345 18.4 18 4 increased thermal nociceptive threshold 0.00536192155882979 0.0349614151444013 0.844068340418705 0.516483516483517 18.4 18 4 decreased neuronal precursor cell number 0.0849805470793448 0.251354471890452 0.843489021036126 0.516129032258065 18.4 18 4 impaired swimming 0.0170661761642826 0.0843978393810197 0.84189150395083 0.515151515151515 18.4 18 4 abnormal skeleton physiology 0.0784970465961139 0.234164528527763 0.84189150395083 0.515151515151515 18.4 18 4 decreased systemic arterial blood pressure 0.0784970465961139 0.234164528527763 0.84189150395083 0.515151515151515 18.4 18 4 dilated heart atrium 0.0784970465961139 0.234164528527763 0.84189150395083 0.515151515151515 18.4 18 4 head tossing 0.0784970465961139 0.234164528527763 0.84189150395083 0.515151515151515 18.4 18 4 abnormal dermal layer morphology 0.0725692077649142 0.231134320506049 0.840476560246711 0.514285714285714 18.4 18 4 decreased circulating thyroxine level 0.0725692077649142 0.231134320506049 0.840476560246711 0.514285714285714 18.4 18 4 increased brown adipose tissue amount 0.0671403234257481 0.224628856115062 0.839214583429524 0.513513513513513 18.4 18 4 increased white adipose tissue amount 0.0671403234257481 0.224628856115062 0.839214583429524 0.513513513513513 18.4 18 4 abnormal pancreatic beta cell physiology 0.0671403234257481 0.224628856115062 0.839214583429524 0.513513513513513 18.4 18 4 abnormal cytokine secretion 0.00050453417437789 0.00488338038429961 0.838354144690532 0.512987012987013 18.4 18 4 increased B cell number 0.00225802676947735 0.0171506613406868 0.838082040132048 0.512820512820513 18.4 18 4 increased vascular permeability 0.062160955519668 0.209661527939219 0.838082040132048 0.512820512820513 18.4 18 4 increased autoantibody level 0.062160955519668 0.209661527939219 0.838082040132048 0.512820512820513 18.4 18 4 abnormal response to injury 0.062160955519668 0.209661527939219 0.838082040132048 0.512820512820513 18.4 18 4 decreased trabecular bone volume 0.062160955519668 0.209661527939219 0.838082040132048 0.512820512820513 18.4 18 4 abnormal response/metabolism to endogenous compounds 0.0098126516098613 0.0554749338171136 0.837059988863594 0.51219512195122 18.4 18 4 abnormal cholesterol homeostasis 0.0575877452424965 0.19677131358614 0.837059988863594 0.51219512195122 18.4 18 4 decreased anxiety-related response 0.00185241382745996 0.0144901867792662 0.837059988863594 0.51219512195122 18.4 18 4 abnormal male reproductive system morphology 0.0533824652586644 0.187021449868444 0.836133012131741 0.511627906976744 18.4 18 4 short femur 0.0079935892678887 0.046403858352096 0.835701125245309 0.511363636363636 18.4 18 4 abnormal ovarian follicle morphology 0.0495112554178762 0.181650808041249 0.835288433331608 0.511111111111111 18.4 18 4 increased circulating corticosterone level 0.0495112554178762 0.181650808041249 0.835288433331608 0.511111111111111 18.4 18 4 increased circulating glucose level 0.00102570699389559 0.00896817626472854 0.834515733578295 0.51063829787234 18.4 18 4 abnormal tibia morphology 0.0459439996272222 0.169563351739934 0.834515733578295 0.51063829787234 18.4 18 4 abnormal T-helper 1 physiology 0.0459439996272222 0.169563351739934 0.834515733578295 0.51063829787234 18.4 18 4 abnormal long bone hypertrophic chondrocyte zone 0.0426538127454783 0.15800649174144 0.833806111355864 0.510204081632653 18.4 18 4 abnormal cued conditioning behavior 0.0396166142663481 0.154340372729117 0.83315214577833 0.509803921568627 18.4 18 4 abnormal learning/memory/conditioning 0.0342167967975632 0.139990595450557 0.831986898021997 0.509090909090909 18.4 18 4 abnormal CNS synaptic transmission 0.00731651430050802 0.0439609403925452 0.825383827402774 0.505050505050505 18.4 18 4 abnormal spermiogenesis 0.0410272358799307 0.155160213883359 0.817129989128747 0.5 18.4 18 4 abnormal cochlea morphology 0.0475671269359381 0.175292091265637 0.817129989128747 0.5 18.4 18 4 increased liver weight 0.0140868546540492 0.0711911898294507 0.817129989128747 0.5 18.4 18 4 abnormal social investigation 0.0186312390703917 0.0889543324138185 0.817129989128747 0.5 18.4 18 4 abnormal inflammatory response 0.0247279706756106 0.106975351401011 0.817129989128747 0.5 18.4 18 4 impaired fertilization 0.0265582410683738 0.114198141153984 0.817129989128747 0.5 18.4 18 4 increased percent body fat/body weight 0.0512522063117906 0.187021449868444 0.817129989128747 0.5 18.4 18 4 abnormal circadian rhythm 0.0694398341869099 0.230524542322751 0.817129989128747 0.5 18.4 18 4 cochlear hair cell degeneration 0.0694398341869099 0.230524542322751 0.817129989128747 0.5 18.4 18 4 impaired ovarian folliculogenesis 0.0811323875754566 0.241407672361182 0.817129989128747 0.5 18.4 18 4 increased width of hypertrophic chondrocyte zone 0.10309235242243 0.2995820404799 0.817129989128747 0.5 18.4 18 4 decreased osteoblast cell number 0.10309235242243 0.2995820404799 0.817129989128747 0.5 18.4 18 4 increased susceptibility to viral infection induced morbidity/mortality 0.10309235242243 0.2995820404799 0.817129989128747 0.5 18.4 18 4 abnormal spleen marginal zone morphology 0.121566725417905 0.344634013952993 0.817129989128747 0.5 18.4 18 4 abnormal microglial cell physiology 0.121566725417905 0.344634013952993 0.817129989128747 0.5 18.4 18 4 liver hemorrhage 0.121566725417905 0.344634013952993 0.817129989128747 0.5 18.4 18 4 no spontaneous movement 0.144121260249315 0.348997252621141 0.817129989128747 0.5 18.4 18 4 prolonged QT interval 0.157312867809299 0.350327447337182 0.817129989128747 0.5 18.4 18 4 abnormal osteoblast morphology 0.157312867809299 0.350327447337182 0.817129989128747 0.5 18.4 18 4 increased circulating total protein level 0.157312867809299 0.350327447337182 0.817129989128747 0.5 18.4 18 4 testis hypoplasia 0.172056573385762 0.379592661904287 0.817129989128747 0.5 18.4 18 4 increased coping response 0.172056573385762 0.379592661904287 0.817129989128747 0.5 18.4 18 4 abnormal tracheal cartilage morphology 0.172056573385762 0.379592661904287 0.817129989128747 0.5 18.4 18 4 parakeratosis 0.172056573385762 0.379592661904287 0.817129989128747 0.5 18.4 18 4 abnormal retinal outer plexiform layer morphology 0.172056573385762 0.379592661904287 0.817129989128747 0.5 18.4 18 4 decreased circulating estradiol level 0.172056573385762 0.379592661904287 0.817129989128747 0.5 18.4 18 4 abnormal sperm midpiece morphology 0.172056573385762 0.379592661904287 0.817129989128747 0.5 18.4 18 4 impaired humoral immune response 0.172056573385762 0.379592661904287 0.817129989128747 0.5 18.4 18 4 waved hair 0.188625580621834 0.411945681998957 0.817129989128747 0.5 18.4 18 4 abnormal trachea morphology 0.188625580621834 0.411945681998957 0.817129989128747 0.5 18.4 18 4 abnormal hyoid bone morphology 0.188625580621834 0.411945681998957 0.817129989128747 0.5 18.4 18 4 abnormal megakaryocyte differentiation 0.207371472137666 0.445454695114373 0.817129989128747 0.5 18.4 18 4 underdeveloped hair follicles 0.207371472137666 0.445454695114373 0.817129989128747 0.5 18.4 18 4 abnormal thyroid cartilage morphology 0.207371472137666 0.445454695114373 0.817129989128747 0.5 18.4 18 4 abnormal Peyer's patch follicle morphology 0.207371472137666 0.445454695114373 0.817129989128747 0.5 18.4 18 4 absent allantois 0.207371472137666 0.445454695114373 0.817129989128747 0.5 18.4 18 4 long tibia 0.207371472137666 0.445454695114373 0.817129989128747 0.5 18.4 18 4 increased gastrointestinal tumor incidence 0.207371472137666 0.445454695114373 0.817129989128747 0.5 18.4 18 4 decreased mast cell number 0.228759568640316 0.48101388587725 0.817129989128747 0.5 18.4 18 4 mixed cellular infiltration to dermis 0.228759568640316 0.48101388587725 0.817129989128747 0.5 18.4 18 4 decreased cochlear coiling 0.228759568640316 0.48101388587725 0.817129989128747 0.5 18.4 18 4 bowed tibia 0.228759568640316 0.48101388587725 0.817129989128747 0.5 18.4 18 4 abnormal epididymis epithelium morphology 0.228759568640316 0.48101388587725 0.817129989128747 0.5 18.4 18 4 abnormal wound healing 0.228759568640316 0.48101388587725 0.817129989128747 0.5 18.4 18 4 sepsis 0.228759568640316 0.48101388587725 0.817129989128747 0.5 18.4 18 4 decreased circulating prolactin level 0.228759568640316 0.48101388587725 0.817129989128747 0.5 18.4 18 4 impaired behavioral response to addictive substance 0.228759568640316 0.48101388587725 0.817129989128747 0.5 18.4 18 4 decreased adipocyte glucose uptake 0.228759568640316 0.48101388587725 0.817129989128747 0.5 18.4 18 4 abnormal adipose tissue distribution 0.282289966541188 0.55572857324612 0.817129989128747 0.5 18.4 18 4 abnormal mineral level 0.282289966541188 0.55572857324612 0.817129989128747 0.5 18.4 18 4 abnormal rectum morphology 0.282289966541188 0.55572857324612 0.817129989128747 0.5 18.4 18 4 decreased digestive secretion 0.282289966541188 0.55572857324612 0.817129989128747 0.5 18.4 18 4 abnormal enteric nervous system morphology 0.282289966541188 0.55572857324612 0.817129989128747 0.5 18.4 18 4 abnormal pilomotor reflex 0.282289966541188 0.55572857324612 0.817129989128747 0.5 18.4 18 4 increased litter size 0.282289966541188 0.55572857324612 0.817129989128747 0.5 18.4 18 4 decreased synaptic depression 0.282289966541188 0.55572857324612 0.817129989128747 0.5 18.4 18 4 abnormal aorta elastic fiber morphology 0.282289966541188 0.55572857324612 0.817129989128747 0.5 18.4 18 4 increased fear-related response 0.282289966541188 0.55572857324612 0.817129989128747 0.5 18.4 18 4 increased osteosarcoma incidence 0.282289966541188 0.55572857324612 0.817129989128747 0.5 18.4 18 4 decreased cochlear nerve compound action potential 0.282289966541188 0.55572857324612 0.817129989128747 0.5 18.4 18 4 small parietal bone 0.282289966541188 0.55572857324612 0.817129989128747 0.5 18.4 18 4 abnormal amacrine cell morphology 0.282289966541188 0.55572857324612 0.817129989128747 0.5 18.4 18 4 hemoperitoneum 0.282289966541188 0.55572857324612 0.817129989128747 0.5 18.4 18 4 hydrometra 0.282289966541188 0.55572857324612 0.817129989128747 0.5 18.4 18 4 reduced cerebellar foliation 0.282289966541188 0.55572857324612 0.817129989128747 0.5 18.4 18 4 impaired behavioral response to cocaine 0.282289966541188 0.55572857324612 0.817129989128747 0.5 18.4 18 4 decreased prostaglandin level 0.282289966541188 0.55572857324612 0.817129989128747 0.5 18.4 18 4 increased type II pneumocyte number 0.282289966541188 0.55572857324612 0.817129989128747 0.5 18.4 18 4 abnormal vitelline vein connection 0.282289966541188 0.55572857324612 0.817129989128747 0.5 18.4 18 4 absent maxillary shelf 0.316735866690995 0.568163638520366 0.817129989128747 0.5 18.4 18 4 absent palatine bone horizontal plate 0.316735866690995 0.568163638520366 0.817129989128747 0.5 18.4 18 4 absent trophoblast giant cells 0.316735866690995 0.568163638520366 0.817129989128747 0.5 18.4 18 4 abnormal pituitary secretion 0.316735866690995 0.568163638520366 0.817129989128747 0.5 18.4 18 4 decreased circulating parathyroid hormone level 0.316735866690995 0.568163638520366 0.817129989128747 0.5 18.4 18 4 abnormal PNS synaptic transmission 0.316735866690995 0.568163638520366 0.817129989128747 0.5 18.4 18 4 abnormal neuron specification 0.316735866690995 0.568163638520366 0.817129989128747 0.5 18.4 18 4 primary sex reversal 0.316735866690995 0.568163638520366 0.817129989128747 0.5 18.4 18 4 abnormal bone healing 0.316735866690995 0.568163638520366 0.817129989128747 0.5 18.4 18 4 acrania 0.316735866690995 0.568163638520366 0.817129989128747 0.5 18.4 18 4 abnormal submandibular gland morphology 0.316735866690995 0.568163638520366 0.817129989128747 0.5 18.4 18 4 increased left ventricle diastolic pressure 0.316735866690995 0.568163638520366 0.817129989128747 0.5 18.4 18 4 increased defecation amount 0.316735866690995 0.568163638520366 0.817129989128747 0.5 18.4 18 4 abnormal reproductive system development 0.316735866690995 0.568163638520366 0.817129989128747 0.5 18.4 18 4 abnormal embryonic erythrocyte morphology 0.316735866690995 0.568163638520366 0.817129989128747 0.5 18.4 18 4 decreased cochlear inner hair cell number 0.316735866690995 0.568163638520366 0.817129989128747 0.5 18.4 18 4 vascular smooth muscle hyperplasia 0.316735866690995 0.568163638520366 0.817129989128747 0.5 18.4 18 4 absent inguinal lymph nodes 0.316735866690995 0.568163638520366 0.817129989128747 0.5 18.4 18 4 absent axillary lymph nodes 0.316735866690995 0.568163638520366 0.817129989128747 0.5 18.4 18 4 ventricular premature beat 0.316735866690995 0.568163638520366 0.817129989128747 0.5 18.4 18 4 abnormal sperm principal piece morphology 0.316735866690995 0.568163638520366 0.817129989128747 0.5 18.4 18 4 abnormal retinal blood vessel pattern 0.316735866690995 0.568163638520366 0.817129989128747 0.5 18.4 18 4 increased T-helper 17 cell number 0.316735866690995 0.568163638520366 0.817129989128747 0.5 18.4 18 4 increased kidney iron level 0.316735866690995 0.568163638520366 0.817129989128747 0.5 18.4 18 4 common ventricle 0.316735866690995 0.568163638520366 0.817129989128747 0.5 18.4 18 4 decreased macrophage apoptosis 0.316735866690995 0.568163638520366 0.817129989128747 0.5 18.4 18 4 increased fatty acid oxidation 0.316735866690995 0.568163638520366 0.817129989128747 0.5 18.4 18 4 increased food intake 0.0161940432004598 0.0806460109332207 0.817129989128747 0.5 18.4 18 4 reddish skin 0.132264541925745 0.348997252621141 0.817129989128747 0.5 18.4 18 4 straub tail 0.132264541925745 0.348997252621141 0.817129989128747 0.5 18.4 18 4 abnormal retinal inner nuclear layer morphology 0.132264541925745 0.348997252621141 0.817129989128747 0.5 18.4 18 4 abnormal zigzag hair morphology 0.253427674978583 0.519490186657788 0.817129989128747 0.5 18.4 18 4 absent visceral yolk sac blood islands 0.253427674978583 0.519490186657788 0.817129989128747 0.5 18.4 18 4 abnormal antigen presentation 0.253427674978583 0.519490186657788 0.817129989128747 0.5 18.4 18 4 abnormal olfactory system physiology 0.253427674978583 0.519490186657788 0.817129989128747 0.5 18.4 18 4 abnormal kidney medulla morphology 0.253427674978583 0.519490186657788 0.817129989128747 0.5 18.4 18 4 abnormal prepulse inhibition 0.253427674978583 0.519490186657788 0.817129989128747 0.5 18.4 18 4 abnormal imprinting 0.253427674978583 0.519490186657788 0.817129989128747 0.5 18.4 18 4 abnormal sagittal suture morphology 0.253427674978583 0.519490186657788 0.817129989128747 0.5 18.4 18 4 abnormal positive T cell selection 0.253427674978583 0.519490186657788 0.817129989128747 0.5 18.4 18 4 abnormal iris pigmentation 0.253427674978583 0.519490186657788 0.817129989128747 0.5 18.4 18 4 decreased cornea thickness 0.253427674978583 0.519490186657788 0.817129989128747 0.5 18.4 18 4 decreased tongue size 0.253427674978583 0.519490186657788 0.817129989128747 0.5 18.4 18 4 decreased compact bone area 0.253427674978583 0.519490186657788 0.817129989128747 0.5 18.4 18 4 decreased response to antigen 0.253427674978583 0.519490186657788 0.817129989128747 0.5 18.4 18 4 abnormal trabecular bone morphology 0.0063558555168388 0.0398241576779257 0.81026335056464 0.495798319327731 18.4 18 4 abnormal T cell differentiation 0.0117381231974498 0.0640319768720537 0.809039593196779 0.495049504950495 18.4 18 4 deafness 0.012574649168929 0.0673400211145552 0.808876150854719 0.494949494949495 18.4 18 4 abnormal skeleton development 0.0235491333537418 0.102320470248791 0.807041964571602 0.493827160493827 18.4 18 4 decreased food intake 0.0252751460911425 0.109247482018622 0.806786571544838 0.493670886075949 18.4 18 4 decreased compact bone thickness 0.0388507294229278 0.152709552301308 0.804934019141751 0.492537313432836 18.4 18 4 abnormal T cell activation 0.0391283062583351 0.153470626993603 0.79504539482797 0.486486486486487 18.4 18 4 abnormal breathing pattern 0.121574410952262 0.344634013952993 0.79504539482797 0.486486486486487 18.4 18 4 increased insulin secretion 0.121574410952262 0.344634013952993 0.79504539482797 0.486486486486487 18.4 18 4 abnormal object recognition memory 0.155866267610306 0.348997252621141 0.790770957221368 0.483870967741935 18.4 18 4 abnormal circulating glucose level 0.169765261200211 0.376373518035228 0.788953092951893 0.482758620689655 18.4 18 4 enlarged epididymis 0.169765261200211 0.376373518035228 0.788953092951893 0.482758620689655 18.4 18 4 rectal prolapse 0.185195710955532 0.405166518031562 0.786865915457312 0.481481481481481 18.4 18 4 abnormal type II pneumocyte morphology 0.185195710955532 0.405166518031562 0.786865915457312 0.481481481481481 18.4 18 4 abnormal female meiosis 0.087900711861296 0.259837220148513 0.785701912623795 0.480769230769231 18.4 18 4 abnormal inner ear vestibule morphology 0.202392865256401 0.43837609132184 0.784444789563597 0.48 18.4 18 4 abnormal cochlear outer hair cell morphology 0.202392865256401 0.43837609132184 0.784444789563597 0.48 18.4 18 4 abnormal energy expenditure 0.202392865256401 0.43837609132184 0.784444789563597 0.48 18.4 18 4 abnormal eye electrophysiology 0.0158101107064766 0.0788919766948055 0.783364287098633 0.479338842975207 18.4 18 4 abnormal hair shaft morphology 0.10243473492107 0.298193567134184 0.783082906248382 0.479166666666667 18.4 18 4 abnormal epidermal layer morphology 0.0599847543913456 0.204260200613925 0.781602598297062 0.478260869565217 18.4 18 4 abnormal blood vessel physiology 0.221646547231264 0.474072043196705 0.781602598297062 0.478260869565217 18.4 18 4 pancreas inflammation 0.221646547231264 0.474072043196705 0.781602598297062 0.478260869565217 18.4 18 4 abnormal crista ampullaris morphology 0.221646547231264 0.474072043196705 0.781602598297062 0.478260869565217 18.4 18 4 decreased epididymis weight 0.221646547231264 0.474072043196705 0.781602598297062 0.478260869565217 18.4 18 4 abnormal B cell morphology 0.221646547231264 0.474072043196705 0.781602598297062 0.478260869565217 18.4 18 4 skin lesions 0.0746249926180903 0.234164528527763 0.778219037265473 0.476190476190476 18.4 18 4 trunk curl 0.243320001762434 0.509906069405268 0.778219037265473 0.476190476190476 18.4 18 4 abnormal associative learning 0.243320001762434 0.509906069405268 0.778219037265473 0.476190476190476 18.4 18 4 increased vasoconstriction 0.243320001762434 0.509906069405268 0.778219037265473 0.476190476190476 18.4 18 4 dry skin 0.243320001762434 0.509906069405268 0.778219037265473 0.476190476190476 18.4 18 4 increased acute inflammation 0.243320001762434 0.509906069405268 0.778219037265473 0.476190476190476 18.4 18 4 abnormal male meiosis 0.0803160812543777 0.239121785900975 0.776943268351923 0.475409836065574 18.4 18 4 increased grooming behavior 0.151973295556329 0.348997252621141 0.774123147595655 0.473684210526316 18.4 18 4 hyporesponsive to tactile stimuli 0.151973295556329 0.348997252621141 0.774123147595655 0.473684210526316 18.4 18 4 eyelids fail to open 0.267877877606292 0.546857792815471 0.774123147595655 0.473684210526316 18.4 18 4 decreased fertilization frequency 0.267877877606292 0.546857792815471 0.774123147595655 0.473684210526316 18.4 18 4 reduced long term depression 0.164870065007073 0.366992650295387 0.771733878621594 0.472222222222222 18.4 18 4 decreased pancreatic beta cell number 0.17904951880201 0.394495728981399 0.769063519179997 0.470588235294118 18.4 18 4 distended urinary bladder 0.295929280297005 0.568163638520366 0.769063519179997 0.470588235294118 18.4 18 4 hyperlipidemia 0.295929280297005 0.568163638520366 0.769063519179997 0.470588235294118 18.4 18 4 abnormal cranial suture morphology 0.295929280297005 0.568163638520366 0.769063519179997 0.470588235294118 18.4 18 4 abnormal melanosome morphology 0.295929280297005 0.568163638520366 0.769063519179997 0.470588235294118 18.4 18 4 pancytopenia 0.295929280297005 0.568163638520366 0.769063519179997 0.470588235294118 18.4 18 4 abnormal circulating chemokine level 0.295929280297005 0.568163638520366 0.769063519179997 0.470588235294118 18.4 18 4 abnormal electroretinogram waveform feature 0.295929280297005 0.568163638520366 0.769063519179997 0.470588235294118 18.4 18 4 increased susceptibility to pharmacologically induced seizures 0.046058065100545 0.169858320144708 0.7660593648082 0.46875 18.4 18 4 increased anxiety-related response 0.0208201054709348 0.0954582475372397 0.764222291990914 0.467625899280576 18.4 18 4 abnormal humoral immune response 0.042061326749509 0.155927794768113 0.762654656520164 0.466666666666667 18.4 18 4 gastrointestinal hemorrhage 0.21193898000973 0.454677199460287 0.762654656520164 0.466666666666667 18.4 18 4 arrested T cell differentiation 0.21193898000973 0.454677199460287 0.762654656520164 0.466666666666667 18.4 18 4 decreased salivation 0.32829687754063 0.568163638520366 0.762654656520164 0.466666666666667 18.4 18 4 abnormal pup retrieval 0.32829687754063 0.568163638520366 0.762654656520164 0.466666666666667 18.4 18 4 increased airway responsiveness 0.32829687754063 0.568163638520366 0.762654656520164 0.466666666666667 18.4 18 4 joint inflammation 0.32829687754063 0.568163638520366 0.762654656520164 0.466666666666667 18.4 18 4 decreased aggression towards males 0.32829687754063 0.568163638520366 0.762654656520164 0.466666666666667 18.4 18 4 abnormal dendritic cell morphology 0.32829687754063 0.568163638520366 0.762654656520164 0.466666666666667 18.4 18 4 abnormal aorta wall morphology 0.32829687754063 0.568163638520366 0.762654656520164 0.466666666666667 18.4 18 4 ostium primum atrial septal defect 0.32829687754063 0.568163638520366 0.762654656520164 0.466666666666667 18.4 18 4 abnormal microglial cell activation 0.32829687754063 0.568163638520366 0.762654656520164 0.466666666666667 18.4 18 4 abnormal respiration 0.231069390781346 0.485665491819687 0.758763561333836 0.464285714285714 18.4 18 4 hyperkeratosis 0.0947701451126186 0.277832334670169 0.757917671075939 0.463768115942029 18.4 18 4 abnormal excitatory postsynaptic potential 0.0744269835026886 0.234164528527763 0.757339989924204 0.463414634146341 18.4 18 4 scaly skin 0.171882924059513 0.379592661904287 0.757339989924204 0.463414634146341 18.4 18 4 arrested B cell differentiation 0.171882924059513 0.379592661904287 0.757339989924204 0.463414634146341 18.4 18 4 increased tumor growth/size 0.171882924059513 0.379592661904287 0.757339989924204 0.463414634146341 18.4 18 4 increased susceptibility to injury 0.141407884319081 0.348997252621141 0.754273836118843 0.461538461538462 18.4 18 4 impaired macrophage chemotaxis 0.186105025772255 0.406976924490975 0.754273836118843 0.461538461538462 18.4 18 4 decreased Peyer's patch number 0.252339955262475 0.519490186657788 0.754273836118843 0.461538461538462 18.4 18 4 small trigeminal ganglion 0.366133644031188 0.568163638520366 0.754273836118843 0.461538461538462 18.4 18 4 tight skin 0.366133644031188 0.568163638520366 0.754273836118843 0.461538461538462 18.4 18 4 lymphoid hypoplasia 0.366133644031188 0.568163638520366 0.754273836118843 0.461538461538462 18.4 18 4 abnormal intercostal muscle morphology 0.366133644031188 0.568163638520366 0.754273836118843 0.461538461538462 18.4 18 4 abnormal insulin secretion 0.366133644031188 0.568163638520366 0.754273836118843 0.461538461538462 18.4 18 4 muscle fatigue 0.366133644031188 0.568163638520366 0.754273836118843 0.461538461538462 18.4 18 4 abnormal retinal inner plexiform layer morphology 0.366133644031188 0.568163638520366 0.754273836118843 0.461538461538462 18.4 18 4 small interparietal bone 0.366133644031188 0.568163638520366 0.754273836118843 0.461538461538462 18.4 18 4 decreased endocochlear potential 0.366133644031188 0.568163638520366 0.754273836118843 0.461538461538462 18.4 18 4 increased circulating ammonia level 0.366133644031188 0.568163638520366 0.754273836118843 0.461538461538462 18.4 18 4 hyperalgesia 0.366133644031188 0.568163638520366 0.754273836118843 0.461538461538462 18.4 18 4 abnormal hair follicle inner root sheath morphology 0.366133644031188 0.568163638520366 0.754273836118843 0.461538461538462 18.4 18 4 abnormal immune system physiology 0.0413283476829284 0.155656798138583 0.751232409360299 0.459677419354839 18.4 18 4 increased stereotypic behavior 0.276082737511387 0.55572857324612 0.749035823368018 0.458333333333333 18.4 18 4 abnormal action potential 0.112948133870575 0.325183429401684 0.747090275774854 0.457142857142857 18.4 18 4 abnormal intestinal goblet cell morphology 0.218737730996379 0.468858341967681 0.747090275774854 0.457142857142857 18.4 18 4 delayed wound healing 0.177405704474243 0.391220469751488 0.746075207465377 0.456521739130435 18.4 18 4 hypertension 0.19153401284215 0.41793057626741 0.742845444662497 0.454545454545455 18.4 18 4 abnormal gametogenesis 0.19153401284215 0.41793057626741 0.742845444662497 0.454545454545455 18.4 18 4 abnormal basisphenoid bone morphology 0.302706192076326 0.568163638520366 0.742845444662497 0.454545454545455 18.4 18 4 decreased susceptibility to viral infection induced morbidity/mortality 0.302706192076326 0.568163638520366 0.742845444662497 0.454545454545455 18.4 18 4 increased mast cell number 0.411132942390422 0.60375271369205 0.742845444662497 0.454545454545455 18.4 18 4 abnormal large intestine morphology 0.411132942390422 0.60375271369205 0.742845444662497 0.454545454545455 18.4 18 4 abnormal enteric ganglia morphology 0.411132942390422 0.60375271369205 0.742845444662497 0.454545454545455 18.4 18 4 focal hepatic necrosis 0.411132942390422 0.60375271369205 0.742845444662497 0.454545454545455 18.4 18 4 vasculitis 0.411132942390422 0.60375271369205 0.742845444662497 0.454545454545455 18.4 18 4 decreased post-tetanic potentiation 0.411132942390422 0.60375271369205 0.742845444662497 0.454545454545455 18.4 18 4 allodynia 0.411132942390422 0.60375271369205 0.742845444662497 0.454545454545455 18.4 18 4 pulmonary hypertension 0.411132942390422 0.60375271369205 0.742845444662497 0.454545454545455 18.4 18 4 enlarged placenta 0.411132942390422 0.60375271369205 0.742845444662497 0.454545454545455 18.4 18 4 abnormal platelet aggregation 0.411132942390422 0.60375271369205 0.742845444662497 0.454545454545455 18.4 18 4 aberrant origin of the right subclavian artery 0.411132942390422 0.60375271369205 0.742845444662497 0.454545454545455 18.4 18 4 abnormal extraembryonic ectoderm morphology 0.411132942390422 0.60375271369205 0.742845444662497 0.454545454545455 18.4 18 4 increased pancreatic beta cell proliferation 0.411132942390422 0.60375271369205 0.742845444662497 0.454545454545455 18.4 18 4 decreased colon length 0.411132942390422 0.60375271369205 0.742845444662497 0.454545454545455 18.4 18 4 abnormal T cell subpopulation ratio 0.237483505736895 0.498935997061254 0.742845444662497 0.454545454545455 18.4 18 4 autoimmune response 0.258116507868078 0.52844840602621 0.73805289340661 0.451612903225806 18.4 18 4 abnormal CD8-positive, alpha beta T cell morphology 0.258116507868078 0.52844840602621 0.73805289340661 0.451612903225806 18.4 18 4 abnormal intestine physiology 0.258116507868078 0.52844840602621 0.73805289340661 0.451612903225806 18.4 18 4 increased bone mineral density 0.0709372397375574 0.230524542322751 0.737586361868426 0.451327433628319 18.4 18 4 abnormal response to novel object 0.181785363924779 0.400169108639725 0.73701920588083 0.450980392156863 18.4 18 4 abnormal thrombosis 0.181785363924779 0.400169108639725 0.73701920588083 0.450980392156863 18.4 18 4 brain inflammation 0.332720666048121 0.568163638520366 0.735416990215872 0.45 18.4 18 4 abnormal dopamine level 0.332720666048121 0.568163638520366 0.735416990215872 0.45 18.4 18 4 decreased paired-pulse facilitation 0.332720666048121 0.568163638520366 0.735416990215872 0.45 18.4 18 4 decreased threshold for auditory brainstem response 0.241903146275314 0.508006818370488 0.731116306062563 0.447368421052632 18.4 18 4 increased systemic arterial blood pressure 0.210846016262473 0.452722887745275 0.730201266881008 0.446808510638298 18.4 18 4 altered response to myocardial infarction 0.227205800086859 0.479774556635028 0.726337768114442 0.444444444444444 18.4 18 4 impaired wound healing 0.261831863787824 0.535614112806096 0.726337768114442 0.444444444444444 18.4 18 4 head tilt 0.261831863787824 0.535614112806096 0.726337768114442 0.444444444444444 18.4 18 4 abnormal heart shape 0.366775526824476 0.568163638520366 0.726337768114442 0.444444444444444 18.4 18 4 decreased heart rate variability 0.366775526824476 0.568163638520366 0.726337768114442 0.444444444444444 18.4 18 4 abnormal pregnancy 0.366775526824476 0.568163638520366 0.726337768114442 0.444444444444444 18.4 18 4 atrioventricular block 0.366775526824476 0.568163638520366 0.726337768114442 0.444444444444444 18.4 18 4 impaired leukocyte tethering or rolling 0.366775526824476 0.568163638520366 0.726337768114442 0.444444444444444 18.4 18 4 decreased susceptibility to injury 0.177864374728823 0.392058158739873 0.720997049231247 0.441176470588235 18.4 18 4 abnormal nervous system electrophysiology 0.149672725308369 0.348997252621141 0.719852609470563 0.44047619047619 18.4 18 4 decreased placenta weight 0.33398192285459 0.568163638520366 0.719074390433297 0.44 18.4 18 4 impaired natural killer cell mediated cytotoxicity 0.216017069031705 0.463226257945144 0.716780692218199 0.43859649122807 18.4 18 4 abnormal crypts of Lieberkuhn morphology 0.307459840370905 0.568163638520366 0.714988740487653 0.4375 18.4 18 4 abnormal long term potentiation 0.307459840370905 0.568163638520366 0.714988740487653 0.4375 18.4 18 4 abnormal meiosis 0.405714784463095 0.60375271369205 0.714988740487653 0.4375 18.4 18 4 large intestinal inflammation 0.405714784463095 0.60375271369205 0.714988740487653 0.4375 18.4 18 4 abnormal Langerhans cell physiology 0.405714784463095 0.60375271369205 0.714988740487653 0.4375 18.4 18 4 abnormal urinary bladder physiology 0.405714784463095 0.60375271369205 0.714988740487653 0.4375 18.4 18 4 abnormal immune system morphology 0.265513565942718 0.542922314247852 0.710547816633693 0.434782608695652 18.4 18 4 abnormal innervation pattern to muscle 0.365059765034067 0.568163638520366 0.710547816633693 0.434782608695652 18.4 18 4 salivary gland inflammation 0.333597831873769 0.568163638520366 0.70817932391158 0.433333333333333 18.4 18 4 abnormal synaptic transmission 0.333597831873769 0.568163638520366 0.70817932391158 0.433333333333333 18.4 18 4 decreased sensitivity to induced morbidity/mortality 0.28551956007372 0.560781607329948 0.705703172429372 0.431818181818182 18.4 18 4 enhanced long term potentiation 0.266283232058958 0.544048903282676 0.700397133538926 0.428571428571429 18.4 18 4 abnormal stria vascularis morphology 0.362294820653043 0.568163638520366 0.700397133538926 0.428571428571429 18.4 18 4 abnormal circulating cholesterol level 0.362294820653043 0.568163638520366 0.700397133538926 0.428571428571429 18.4 18 4 abnormal spleen germinal center morphology 0.362294820653043 0.568163638520366 0.700397133538926 0.428571428571429 18.4 18 4 absent atrioventricular cushions 0.450663120820643 0.655761633835243 0.700397133538926 0.428571428571429 18.4 18 4 extended life span 0.450663120820643 0.655761633835243 0.700397133538926 0.428571428571429 18.4 18 4 abnormal spleen periarteriolar lymphoid sheath morphology 0.450663120820643 0.655761633835243 0.700397133538926 0.428571428571429 18.4 18 4 abnormal hair cuticle 0.450663120820643 0.655761633835243 0.700397133538926 0.428571428571429 18.4 18 4 skeletal muscle necrosis 0.450663120820643 0.655761633835243 0.700397133538926 0.428571428571429 18.4 18 4 enlarged stomach 0.450663120820643 0.655761633835243 0.700397133538926 0.428571428571429 18.4 18 4 abnormal respiratory motile cilium physiology 0.450663120820643 0.655761633835243 0.700397133538926 0.428571428571429 18.4 18 4 abnormal NK cell physiology 0.266007370214661 0.54370857305585 0.696569826798276 0.426229508196721 18.4 18 4 abnormal leukocyte cell number 0.393852699088808 0.588590320807096 0.691417683108939 0.423076923076923 18.4 18 4 small seminal vesicle 0.393852699088808 0.588590320807096 0.691417683108939 0.423076923076923 18.4 18 4 abnormal tectorial membrane morphology 0.393852699088808 0.588590320807096 0.691417683108939 0.423076923076923 18.4 18 4 decreased eosinophil cell number 0.282659752743474 0.55572857324612 0.68945342832738 0.421875 18.4 18 4 decreased grooming behavior 0.438701089892247 0.639852806277903 0.688109464529471 0.421052631578947 18.4 18 4 absent mature ovarian follicles 0.388112121433435 0.580534517177192 0.685334829591852 0.419354838709677 18.4 18 4 decreased susceptibility to bacterial infection induced morbidity/mortality 0.388112121433435 0.580534517177192 0.685334829591852 0.419354838709677 18.4 18 4 impaired macrophage phagocytosis 0.35185939744602 0.568163638520366 0.684108828107788 0.418604651162791 18.4 18 4 abnormal eye physiology 0.320331332688395 0.568163638520366 0.680941657607289 0.416666666666667 18.4 18 4 increased susceptibility to bacterial infection induced morbidity/mortality 0.296799059203976 0.568163638520366 0.680941657607289 0.416666666666667 18.4 18 4 abnormal cardiac muscle contractility 0.428614784693125 0.625325089105072 0.680941657607289 0.416666666666667 18.4 18 4 absent optic nerve 0.503163639425589 0.700010935722121 0.680941657607289 0.416666666666667 18.4 18 4 abnormal tracheal ciliated epithelium morphology 0.503163639425589 0.700010935722121 0.680941657607289 0.416666666666667 18.4 18 4 abnormal AMPA-mediated synaptic currents 0.503163639425589 0.700010935722121 0.680941657607289 0.416666666666667 18.4 18 4 abnormal alisphenoid bone morphology 0.503163639425589 0.700010935722121 0.680941657607289 0.416666666666667 18.4 18 4 absent tail 0.503163639425589 0.700010935722121 0.680941657607289 0.416666666666667 18.4 18 4 stria vascularis degeneration 0.503163639425589 0.700010935722121 0.680941657607289 0.416666666666667 18.4 18 4 absent cochlear hair cells 0.503163639425589 0.700010935722121 0.680941657607289 0.416666666666667 18.4 18 4 abnormal cochlear outer hair cell physiology 0.503163639425589 0.700010935722121 0.680941657607289 0.416666666666667 18.4 18 4 abnormal palatine bone morphology 0.503163639425589 0.700010935722121 0.680941657607289 0.416666666666667 18.4 18 4 decreased keratinocyte proliferation 0.503163639425589 0.700010935722121 0.680941657607289 0.416666666666667 18.4 18 4 decreased oligodendrocyte number 0.503163639425589 0.700010935722121 0.680941657607289 0.416666666666667 18.4 18 4 abnormal aorta elastic tissue morphology 0.503163639425589 0.700010935722121 0.680941657607289 0.416666666666667 18.4 18 4 decreased compensatory feeding amount 0.503163639425589 0.700010935722121 0.680941657607289 0.416666666666667 18.4 18 4 absent long term depression 0.419764814479179 0.612593121746529 0.67624550824448 0.413793103448276 18.4 18 4 increased double-positive T cell number 0.419764814479179 0.612593121746529 0.67624550824448 0.413793103448276 18.4 18 4 abnormal inhibitory postsynaptic currents 0.333728730482975 0.568163638520366 0.672930579282497 0.411764705882353 18.4 18 4 lung hemorrhage 0.411805374692247 0.60375271369205 0.672930579282497 0.411764705882353 18.4 18 4 abnormal bone remodeling 0.411805374692247 0.60375271369205 0.672930579282497 0.411764705882353 18.4 18 4 decreased regulatory T cell number 0.411805374692247 0.60375271369205 0.672930579282497 0.411764705882353 18.4 18 4 abnormal urinary bladder morphology 0.482564637379359 0.683404207283342 0.672930579282497 0.411764705882353 18.4 18 4 increased incidence of corneal inflammation 0.482564637379359 0.683404207283342 0.672930579282497 0.411764705882353 18.4 18 4 abnormal heart rate 0.482564637379359 0.683404207283342 0.672930579282497 0.411764705882353 18.4 18 4 abnormal tendon morphology 0.482564637379359 0.683404207283342 0.672930579282497 0.411764705882353 18.4 18 4 abnormal lens fiber morphology 0.40452579715001 0.60375271369205 0.670465632105638 0.41025641025641 18.4 18 4 increased activated T cell number 0.46696999116043 0.674361598265062 0.668560900196247 0.409090909090909 18.4 18 4 abnormal temporal bone morphology 0.46696999116043 0.674361598265062 0.668560900196247 0.409090909090909 18.4 18 4 increased dopamine level 0.443295261107798 0.646363987107648 0.663918116167107 0.40625 18.4 18 4 decreased inflammatory response 0.355501936216852 0.568163638520366 0.661486181675652 0.404761904761905 18.4 18 4 decreased IgA level 0.409818304579275 0.60375271369205 0.659989606603988 0.403846153846154 18.4 18 4 increased neutrophil cell number 0.334826932851857 0.568163638520366 0.653703991302997 0.4 18.4 18 4 abnormal feces composition 0.491703359252147 0.68656306827938 0.653703991302997 0.4 18.4 18 4 abnormal male reproductive system physiology 0.509354705788329 0.708030081390595 0.653703991302997 0.4 18.4 18 4 abnormal thymocyte activation 0.509354705788329 0.708030081390595 0.653703991302997 0.4 18.4 18 4 nuclear cataracts 0.509354705788329 0.708030081390595 0.653703991302997 0.4 18.4 18 4 abnormal pain threshold 0.477209469549452 0.683404207283342 0.653703991302997 0.4 18.4 18 4 decreased chondrocyte number 0.532240616340652 0.734079525685664 0.653703991302997 0.4 18.4 18 4 hyperpigmentation 0.532240616340652 0.734079525685664 0.653703991302997 0.4 18.4 18 4 abnormal respiratory system morphology 0.532240616340652 0.734079525685664 0.653703991302997 0.4 18.4 18 4 altered righting response 0.532240616340652 0.734079525685664 0.653703991302997 0.4 18.4 18 4 arthritis 0.532240616340652 0.734079525685664 0.653703991302997 0.4 18.4 18 4 increased alcohol consumption 0.532240616340652 0.734079525685664 0.653703991302997 0.4 18.4 18 4 abnormal zygomatic bone morphology 0.532240616340652 0.734079525685664 0.653703991302997 0.4 18.4 18 4 decreased trabecular bone mass 0.532240616340652 0.734079525685664 0.653703991302997 0.4 18.4 18 4 blistering 0.532483707955949 0.734079525685664 0.639493034970324 0.391304347826087 18.4 18 4 abnormal retinal rod cell morphology 0.556248616823374 0.761722231956038 0.635545547100136 0.388888888888889 18.4 18 4 blepharoptosis 0.556248616823374 0.761722231956038 0.635545547100136 0.388888888888889 18.4 18 4 increased circulating glycerol level 0.556248616823374 0.761722231956038 0.635545547100136 0.388888888888889 18.4 18 4 increased susceptibility to autoimmune disorder 0.556248616823374 0.761722231956038 0.635545547100136 0.388888888888889 18.4 18 4 abnormal sperm axoneme morphology 0.556248616823374 0.761722231956038 0.635545547100136 0.388888888888889 18.4 18 4 decreased fluid intake 0.556248616823374 0.761722231956038 0.635545547100136 0.388888888888889 18.4 18 4 abnormal body temperature homeostasis 0.533481478885882 0.734079525685664 0.632616765777094 0.387096774193548 18.4 18 4 decreased monocyte cell number 0.513717265927626 0.713894803907805 0.628561530099036 0.384615384615385 18.4 18 4 abnormal mast cell morphology 0.588807386547088 0.779683554909765 0.628561530099036 0.384615384615385 18.4 18 4 abnormal sympathetic ganglion morphology 0.588807386547088 0.779683554909765 0.628561530099036 0.384615384615385 18.4 18 4 abnormal digestion 0.588807386547088 0.779683554909765 0.628561530099036 0.384615384615385 18.4 18 4 abnormal otolith morphology 0.588807386547088 0.779683554909765 0.628561530099036 0.384615384615385 18.4 18 4 vestibular hair cell degeneration 0.588807386547088 0.779683554909765 0.628561530099036 0.384615384615385 18.4 18 4 increased circulating thyroid-stimulating hormone level 0.588807386547088 0.779683554909765 0.628561530099036 0.384615384615385 18.4 18 4 decreased luteinizing hormone level 0.588807386547088 0.779683554909765 0.628561530099036 0.384615384615385 18.4 18 4 abnormal gut flora balance 0.588807386547088 0.779683554909765 0.628561530099036 0.384615384615385 18.4 18 4 abnormal clavicle morphology 0.576790731342755 0.779683554909765 0.622575229812378 0.380952380952381 18.4 18 4 abnormal digestive system physiology 0.551071971162755 0.755881736017289 0.621018791737848 0.38 18.4 18 4 abnormal intestinal absorption 0.608156115467185 0.779683554909765 0.61284749184656 0.375 18.4 18 4 apnea 0.594805061913644 0.779683554909765 0.61284749184656 0.375 18.4 18 4 small lymph nodes 0.594805061913644 0.779683554909765 0.61284749184656 0.375 18.4 18 4 abnormal level of surface class II molecules 0.608156115467185 0.779683554909765 0.61284749184656 0.375 18.4 18 4 abnormal pancreatic alpha cell morphology 0.608156115467185 0.779683554909765 0.61284749184656 0.375 18.4 18 4 abnormal intestinal lipid absorption 0.608156115467185 0.779683554909765 0.61284749184656 0.375 18.4 18 4 impaired behavioral response to xenobiotic 0.602680104868482 0.779683554909765 0.607010849067069 0.371428571428571 18.4 18 4 abnormal nail morphology 0.624818007533199 0.782703424240733 0.602095781463287 0.368421052631579 18.4 18 4 stereotypic behavior 0.624818007533199 0.782703424240733 0.602095781463287 0.368421052631579 18.4 18 4 altered susceptibility to infection 0.624818007533199 0.782703424240733 0.602095781463287 0.368421052631579 18.4 18 4 abnormal leukocyte migration 0.63454595452902 0.791988490662789 0.597133453594084 0.365384615384615 18.4 18 4 decreased macrophage cell number 0.641484433844165 0.794272040411827 0.594276355729998 0.363636363636364 18.4 18 4 abnormal food intake 0.659753719195513 0.815877393238299 0.592123180528077 0.36231884057971 18.4 18 4 abnormal systemic arterial blood pressure 0.65101835246189 0.805876164095024 0.590149436592984 0.361111111111111 18.4 18 4 increased circulating luteinizing hormone level 0.66488600057942 0.82181561562301 0.583664277949105 0.357142857142857 18.4 18 4 decreased circulating progesterone level 0.66488600057942 0.82181561562301 0.583664277949105 0.357142857142857 18.4 18 4 abnormal endplate potential 0.665554200839558 0.822028835446078 0.583664277949105 0.357142857142857 18.4 18 4 decreased vascular permeability 0.665554200839558 0.822028835446078 0.583664277949105 0.357142857142857 18.4 18 4 abnormal voluntary movement 0.665554200839558 0.822028835446078 0.583664277949105 0.357142857142857 18.4 18 4 decreased growth hormone level 0.676660558060545 0.835538911975977 0.576797639384998 0.352941176470588 18.4 18 4 decreased cytotoxic T cell cytolysis 0.686349359541793 0.847292323503826 0.576797639384998 0.352941176470588 18.4 18 4 enhanced behavioral response to xenobiotic 0.686990554626589 0.847663196742877 0.571990992390123 0.35 18.4 18 4 abnormal circulating cytokine level 0.686990554626589 0.847663196742877 0.571990992390123 0.35 18.4 18 4 increased susceptibility to induced arthritis 0.714252912996943 0.881083124760673 0.563537923537067 0.344827586206897 18.4 18 4 decreased susceptibility to parasitic infection 0.722334737226102 0.890831759469473 0.561776867526013 0.34375 18.4 18 4 abnormal macrophage chemotaxis 0.736866528679131 0.895872673552951 0.544753326085831 0.333333333333333 18.4 18 4 abnormal single cell response 0.753119841600432 0.897644528394402 0.544753326085831 0.333333333333333 18.4 18 4 abnormal reflex 0.769495149347814 0.907165490048667 0.544753326085831 0.333333333333333 18.4 18 4 decreased susceptibility to induced arthritis 0.803426222697321 0.943812386757774 0.544753326085831 0.333333333333333 18.4 18 4 greasy coat 0.732210993089011 0.892230987686281 0.544753326085831 0.333333333333333 18.4 18 4 increased susceptibility to parasitic infection 0.892056030139571 1 0.52659488188297 0.322222222222222 18.4 18 4 enhanced coordination 0.794914818926174 0.935138620042023 0.525297850154194 0.321428571428571 18.4 18 4 impaired conditioned place preference behavior 0.792160424160637 0.932118758325253 0.522963193042398 0.32 18.4 18 4 intestinal ulcer 0.789944811851904 0.92995159464345 0.519991811263748 0.318181818181818 18.4 18 4 abnormal oogenesis 0.789944811851904 0.92995159464345 0.519991811263748 0.318181818181818 18.4 18 4 abnormal blood-brain barrier function 0.789944811851904 0.92995159464345 0.519991811263748 0.318181818181818 18.4 18 4 abnormal ear morphology 0.788581230746484 0.929027440157558 0.516082098397103 0.315789473684211 18.4 18 4 abnormal response to novelty 0.788581230746484 0.929027440157558 0.516082098397103 0.315789473684211 18.4 18 4 impaired muscle relaxation 0.788599573826204 0.929027440157558 0.510706243205467 0.3125 18.4 18 4 abnormal leukocyte adhesion 0.863103773831454 0.995119646538003 0.502849224079229 0.307692307692308 18.4 18 4 increased susceptibility to fungal infection 0.830763466214511 0.971339187877131 0.497383471643585 0.304347826086957 18.4 18 4 increased aggression towards mice 0.835240830395229 0.976115370264567 0.480664699487498 0.294117647058824 18.4 18 4 abnormal glutamate-mediated receptor currents 0.835240830395229 0.976115370264567 0.480664699487498 0.294117647058824 18.4 18 4 abnormal cellular extravasation 0.86502165212374 0.997099795948935 0.476659160325102 0.291666666666667 18.4 18 4 hypoalgesia 0.868131942209613 1 0.466931422359284 0.285714285714286 18.4 18 4 decreased chemically-elicited antinociception 0.903254196550161 1 0.430068415330919 0.263157894736842 18.4 18 4 abnormal behavioral response to xenobiotic 0.903254196550161 1 0.430068415330919 0.263157894736842 18.4 18 4 abnormal retinal cone cell morphology 0.920989286639369 1 0.426328689980216 0.260869565217391 18.4 18 4 abnormal regulatory T cell physiology 0.920989286639369 1 0.426328689980216 0.260869565217391 18.4 18 4 abnormal stomach mucosa morphology 0.954262614506568 1 0.392222394781798 0.24 18.4 18 4 abnormal channel response 0.959438999946581 1 0.371422722331249 0.227272727272727 18.4 18 4 decreased acute inflammation 0.984108135630582 1 0.326851995651499 0.2 18.4 18 4 increased T follicular helper cell number 0.00135305500696195 0.0144062682619889 2.74685222001325 1 18.3 18 3 abnormal radial glial cell morphology 4.87228585743839e-07 1.78232515740853e-05 2.74685222001325 1 18.3 18 3 decreased circulating bicarbonate level 6.85069247799194e-06 0.000181288271691542 2.74685222001325 1 18.3 18 3 abnormal olfactory bulb layer morphology 0.000360971572216123 0.00490664910321096 2.74685222001325 1 18.3 18 3 increased cardiac cell glucose uptake 0.000360971572216123 0.00490664910321096 2.74685222001325 1 18.3 18 3 decreased transitional stage T2 B cell number 5.20634448692329e-05 0.00103606255289773 2.47216699801193 0.9 18.3 18 3 increased left ventricle systolic pressure 0.000590548915224548 0.00732663554424471 2.4034956925116 0.875 18.3 18 3 abnormal extraembryonic tissue physiology 0.000590548915224548 0.00732663554424471 2.4034956925116 0.875 18.3 18 3 abnormal olfactory bulb mitral cell layer morphology 0.000590548915224548 0.00732663554424471 2.4034956925116 0.875 18.3 18 3 abnormal cerebellum deep nucleus morphology 0.000590548915224548 0.00732663554424471 2.4034956925116 0.875 18.3 18 3 increased caudal vertebrae number 0.000590548915224548 0.00732663554424471 2.4034956925116 0.875 18.3 18 3 abnormal heart echocardiography feature 0.000590548915224548 0.00732663554424471 2.4034956925116 0.875 18.3 18 3 abnormal umbilical vein topology 0.000590548915224548 0.00732663554424471 2.4034956925116 0.875 18.3 18 3 asymmetric rib joints 0.00194904215438753 0.0194318331023607 2.35444476001136 0.857142857142857 18.3 18 3 abnormal brain ventricular system morphology 0.00194904215438753 0.0194318331023607 2.35444476001136 0.857142857142857 18.3 18 3 uremia 0.00194904215438753 0.0194318331023607 2.35444476001136 0.857142857142857 18.3 18 3 abnormal retina inner limiting membrane morphology 0.00194904215438753 0.0194318331023607 2.35444476001136 0.857142857142857 18.3 18 3 ductus venosus stenosis 0.00194904215438753 0.0194318331023607 2.35444476001136 0.857142857142857 18.3 18 3 delayed brain development 0.00631347218069108 0.0469499612839135 2.28904351667771 0.833333333333333 18.3 18 3 abnormal hippocampal fimbria morphology 0.00631347218069108 0.0469499612839135 2.28904351667771 0.833333333333333 18.3 18 3 bile duct inflammation 0.00631347218069108 0.0469499612839135 2.28904351667771 0.833333333333333 18.3 18 3 enlarged pancreas 0.00631347218069108 0.0469499612839135 2.28904351667771 0.833333333333333 18.3 18 3 abnormal heart left atrium morphology 0.00631347218069108 0.0469499612839135 2.28904351667771 0.833333333333333 18.3 18 3 abnormal cholesterol level 0.00631347218069108 0.0469499612839135 2.28904351667771 0.833333333333333 18.3 18 3 abnormal eyelid development 0.00631347218069108 0.0469499612839135 2.28904351667771 0.833333333333333 18.3 18 3 delayed chorioallantoic fusion 0.00631347218069108 0.0469499612839135 2.28904351667771 0.833333333333333 18.3 18 3 abnormal ureteric bud elongation 0.00631347218069108 0.0469499612839135 2.28904351667771 0.833333333333333 18.3 18 3 absent thymus corticomedullary boundary 0.00631347218069108 0.0469499612839135 2.28904351667771 0.833333333333333 18.3 18 3 increased skin tumor incidence 1.0038232039549e-06 3.28553976294451e-05 2.1974817760106 0.8 18.3 18 3 protruding tongue 0.000673551361748389 0.00794056403956928 2.1974817760106 0.8 18.3 18 3 fusion of atlas and odontoid process 0.000673551361748389 0.00794056403956928 2.1974817760106 0.8 18.3 18 3 midline facial cleft 7.66672450440251e-05 0.00140233998519055 2.15824103001041 0.785714285714286 18.3 18 3 abnormal aerobic respiration 9.02519607792678e-06 0.00022562990194817 2.13644061556586 0.777777777777778 18.3 18 3 pancreas cysts 0.00204020651965274 0.0200593427574553 2.13644061556586 0.777777777777778 18.3 18 3 abnormal posterior eye segment morphology 0.00204020651965274 0.0200593427574553 2.13644061556586 0.777777777777778 18.3 18 3 decreased transitional stage T1 B cell number 0.00204020651965274 0.0200593427574553 2.13644061556586 0.777777777777778 18.3 18 3 shortened ST segment 0.00204020651965274 0.0200593427574553 2.13644061556586 0.777777777777778 18.3 18 3 abnormal pulmonary alveolar system morphology 0.00204020651965274 0.0200593427574553 2.13644061556586 0.777777777777778 18.3 18 3 short premaxilla 0.000227771394380416 0.0033426627936359 2.11296324616404 0.769230769230769 18.3 18 3 absent hypoglossal nerve 0.000227771394380416 0.0033426627936359 2.11296324616404 0.769230769230769 18.3 18 3 spleen atrophy 9.104250227897e-06 0.000226468224418938 2.06013916500994 0.75 18.3 18 3 abnormal hair follicle orientation 7.66706484365489e-05 0.00140233998519055 2.06013916500994 0.75 18.3 18 3 kidney degeneration 7.66706484365489e-05 0.00140233998519055 2.06013916500994 0.75 18.3 18 3 increased papilloma incidence 0.000663549155842028 0.00785989773884307 2.06013916500994 0.75 18.3 18 3 dilated bile duct 0.000663549155842028 0.00785989773884307 2.06013916500994 0.75 18.3 18 3 increased osteosarcoma incidence 0.000663549155842028 0.00785989773884307 2.06013916500994 0.75 18.3 18 3 increased fibrosarcoma incidence 0.000663549155842028 0.00785989773884307 2.06013916500994 0.75 18.3 18 3 failure of vascular branching 0.00602452187187648 0.0457587729963137 2.06013916500994 0.75 18.3 18 3 increased sensitivity to skin irradiation 0.00602452187187648 0.0457587729963137 2.06013916500994 0.75 18.3 18 3 abnormal erythrocyte cell number 0.00602452187187648 0.0457587729963137 2.06013916500994 0.75 18.3 18 3 liver cysts 0.00602452187187648 0.0457587729963137 2.06013916500994 0.75 18.3 18 3 abnormal eyelid aperture 0.00602452187187648 0.0457587729963137 2.06013916500994 0.75 18.3 18 3 binucleate 0.00602452187187648 0.0457587729963137 2.06013916500994 0.75 18.3 18 3 abnormal kidney epithelium morphology 0.00602452187187648 0.0457587729963137 2.06013916500994 0.75 18.3 18 3 abnormal sphingomyelin level 0.00602452187187648 0.0457587729963137 2.06013916500994 0.75 18.3 18 3 pleural effusion 0.00602452187187648 0.0457587729963137 2.06013916500994 0.75 18.3 18 3 delayed suture closure 0.00602452187187648 0.0457587729963137 2.06013916500994 0.75 18.3 18 3 abnormal bronchiole epithelium morphology 0.00602452187187648 0.0457587729963137 2.06013916500994 0.75 18.3 18 3 absent hypoglossal canal 0.00602452187187648 0.0457587729963137 2.06013916500994 0.75 18.3 18 3 increased brain apoptosis 0.00602452187187648 0.0457587729963137 2.06013916500994 0.75 18.3 18 3 increased liver adenoma incidence 2.58147412082886e-05 0.000548839049193315 2.02399637264135 0.736842105263158 18.3 18 3 abnormal fontanelle morphology 0.000217718579254999 0.0032624997945591 2.01435829467639 0.733333333333333 18.3 18 3 abnormal cell differentiation 7.14376663049288e-10 5.30451328159732e-08 2.00989186830238 0.731707317073171 18.3 18 3 embryonic lethality before implantation, incomplete penetrance 8.70709248689531e-06 0.000219141287514987 1.99771070546418 0.727272727272727 18.3 18 3 thin hypoglossal nerve 0.00188879474339615 0.019060352633663 1.99771070546418 0.727272727272727 18.3 18 3 abnormal metanephric mesenchyme morphology 7.19901686683536e-05 0.00134138984691033 1.98383771445402 0.722222222222222 18.3 18 3 liver degeneration 2.3956267537825e-05 0.000511512579402057 1.96203730000947 0.714285714285714 18.3 18 3 abnormal blood flow velocity 0.000605531767721392 0.00738362878532825 1.96203730000947 0.714285714285714 18.3 18 3 abnormal viscerocranium morphology 0.000605531767721392 0.00738362878532825 1.96203730000947 0.714285714285714 18.3 18 3 testis degeneration 0.000605531767721392 0.00738362878532825 1.96203730000947 0.714285714285714 18.3 18 3 broad head 0.0172245472464499 0.0993454563985258 1.96203730000947 0.714285714285714 18.3 18 3 skin photosensitivity 0.0172245472464499 0.0993454563985258 1.96203730000947 0.714285714285714 18.3 18 3 absent epidermis stratum corneum 0.0172245472464499 0.0993454563985258 1.96203730000947 0.714285714285714 18.3 18 3 abnormal tumor incidence 0.0172245472464499 0.0993454563985258 1.96203730000947 0.714285714285714 18.3 18 3 aorta coarctation 0.0172245472464499 0.0993454563985258 1.96203730000947 0.714285714285714 18.3 18 3 abnormal vestibular saccular macula morphology 0.0172245472464499 0.0993454563985258 1.96203730000947 0.714285714285714 18.3 18 3 abnormal renal/urinary system physiology 0.0172245472464499 0.0993454563985258 1.96203730000947 0.714285714285714 18.3 18 3 retinal pigment epithelium atrophy 0.0172245472464499 0.0993454563985258 1.96203730000947 0.714285714285714 18.3 18 3 decreased DN4 thymocyte number 0.0172245472464499 0.0993454563985258 1.96203730000947 0.714285714285714 18.3 18 3 decreased brain cholesterol level 0.0172245472464499 0.0993454563985258 1.96203730000947 0.714285714285714 18.3 18 3 abnormal T wave 0.0172245472464499 0.0993454563985258 1.96203730000947 0.714285714285714 18.3 18 3 thick mitral valve cusps 0.0172245472464499 0.0993454563985258 1.96203730000947 0.714285714285714 18.3 18 3 small tail bud 0.0172245472464499 0.0993454563985258 1.96203730000947 0.714285714285714 18.3 18 3 decreased CD8-positive, naive alpha-beta T cell number 0.0172245472464499 0.0993454563985258 1.96203730000947 0.714285714285714 18.3 18 3 enhanced behavioral response to cocaine 0.000197043085703624 0.00304437686762586 1.93895450824465 0.705882352941177 18.3 18 3 abnormal optic stalk morphology 6.48058868292025e-05 0.00121999143434141 1.92279655400928 0.7 18.3 18 3 ketoaciduria 0.0052290685547629 0.0410973397471492 1.92279655400928 0.7 18.3 18 3 bifid ureter 0.0052290685547629 0.0410973397471492 1.92279655400928 0.7 18.3 18 3 abnormal respiratory conducting tube morphology 0.0052290685547629 0.0410973397471492 1.92279655400928 0.7 18.3 18 3 abnormal corneal endothelium morphology 0.0052290685547629 0.0410973397471492 1.92279655400928 0.7 18.3 18 3 ascites 0.0052290685547629 0.0410973397471492 1.92279655400928 0.7 18.3 18 3 tachypnea 0.0052290685547629 0.0410973397471492 1.92279655400928 0.7 18.3 18 3 increased circulating fructosamine level 0.0052290685547629 0.0410973397471492 1.92279655400928 0.7 18.3 18 3 increased cardiomyocyte apoptosis 3.06993579818146e-07 1.17484081507329e-05 1.91447275940318 0.696969696969697 18.3 18 3 failure to gastrulate 1.56363905780219e-09 1.07729795736985e-07 1.91085371827009 0.695652173913043 18.3 18 3 increased foot pad pigmentation 0.00164404911913065 0.0167605417370389 1.90166692154764 0.692307692307692 18.3 18 3 anal atresia 0.00164404911913065 0.0167605417370389 1.90166692154764 0.692307692307692 18.3 18 3 axonal dystrophy 0.00164404911913065 0.0167605417370389 1.90166692154764 0.692307692307692 18.3 18 3 increased circulating thyroxine level 0.00164404911913065 0.0167605417370389 1.90166692154764 0.692307692307692 18.3 18 3 increased mortality induced by gamma-irradiation 2.40285853536936e-06 7.28915927650156e-05 1.89438084138845 0.689655172413793 18.3 18 3 blepharitis 0.000528024027055589 0.00670132534337132 1.88846090125911 0.6875 18.3 18 3 abnormal nasal septum morphology 0.00017203692816516 0.00270871277438079 1.87942520316696 0.684210526315789 18.3 18 3 abnormal vascular branching morphogenesis 5.66330712183888e-05 0.00110140489448724 1.87285378637267 0.681818181818182 18.3 18 3 pulmonary vascular congestion 5.66330712183888e-05 0.00110140489448724 1.87285378637267 0.681818181818182 18.3 18 3 abnormal optic cup morphology 5.39306682188559e-06 0.000148234847728623 1.83123481334217 0.666666666666667 18.3 18 3 abnormal eye pigmentation 0.000146505125411957 0.00235117096427254 1.83123481334217 0.666666666666667 18.3 18 3 delayed kidney development 0.000447148919774164 0.00582347087925777 1.83123481334217 0.666666666666667 18.3 18 3 acidosis 0.000447148919774164 0.00582347087925777 1.83123481334217 0.666666666666667 18.3 18 3 abnormal respiratory system morphology 0.00138115814465418 0.0145269804855276 1.83123481334217 0.666666666666667 18.3 18 3 delayed intramembranous bone ossification 0.00138115814465418 0.0145269804855276 1.83123481334217 0.666666666666667 18.3 18 3 abnormal olfactory nerve morphology 0.00138115814465418 0.0145269804855276 1.83123481334217 0.666666666666667 18.3 18 3 interstitial pneumonia 0.0043392859185044 0.0362822646127049 1.83123481334217 0.666666666666667 18.3 18 3 abnormal embryonic growth/weight/body size 0.0043392859185044 0.0362822646127049 1.83123481334217 0.666666666666667 18.3 18 3 abnormal respiratory function 0.0043392859185044 0.0362822646127049 1.83123481334217 0.666666666666667 18.3 18 3 abnormal rostral-caudal body axis extension 0.0043392859185044 0.0362822646127049 1.83123481334217 0.666666666666667 18.3 18 3 hematuria 0.0043392859185044 0.0362822646127049 1.83123481334217 0.666666666666667 18.3 18 3 decreased red blood cell distribution width 0.0043392859185044 0.0362822646127049 1.83123481334217 0.666666666666667 18.3 18 3 decreased mammary gland epithelial cell proliferation 0.0043392859185044 0.0362822646127049 1.83123481334217 0.666666666666667 18.3 18 3 persistent right dorsal aorta 0.0043392859185044 0.0362822646127049 1.83123481334217 0.666666666666667 18.3 18 3 distorted hair follicle pattern 0.0139931525763239 0.0860518344464915 1.83123481334217 0.666666666666667 18.3 18 3 renal tubular acidosis 0.0139931525763239 0.0860518344464915 1.83123481334217 0.666666666666667 18.3 18 3 abnormal geniculate ganglion morphology 0.0139931525763239 0.0860518344464915 1.83123481334217 0.666666666666667 18.3 18 3 abnormal posterior semicircular canal morphology 0.0139931525763239 0.0860518344464915 1.83123481334217 0.666666666666667 18.3 18 3 biliary cyst 0.0139931525763239 0.0860518344464915 1.83123481334217 0.666666666666667 18.3 18 3 premature neuronal precursor differentiation 0.0139931525763239 0.0860518344464915 1.83123481334217 0.666666666666667 18.3 18 3 abnormal thymus physiology 0.0139931525763239 0.0860518344464915 1.83123481334217 0.666666666666667 18.3 18 3 decreased cellular sensitivity to ionizing radiation 0.0139931525763239 0.0860518344464915 1.83123481334217 0.666666666666667 18.3 18 3 short frontal bone 0.0139931525763239 0.0860518344464915 1.83123481334217 0.666666666666667 18.3 18 3 positive geotaxis 0.0139931525763239 0.0860518344464915 1.83123481334217 0.666666666666667 18.3 18 3 eye opacity 0.0139931525763239 0.0860518344464915 1.83123481334217 0.666666666666667 18.3 18 3 abnormal ductus venosus valve topology 0.0139931525763239 0.0860518344464915 1.83123481334217 0.666666666666667 18.3 18 3 increased cardiac muscle glycogen level 0.0139931525763239 0.0860518344464915 1.83123481334217 0.666666666666667 18.3 18 3 decreased platelet dense granule number 0.0139931525763239 0.0860518344464915 1.83123481334217 0.666666666666667 18.3 18 3 decreased hair follicle number 5.21417342544378e-07 1.87974730373789e-05 1.80713961842977 0.657894736842105 18.3 18 3 failure of primitive streak formation 4.5744678830893e-06 0.000128576145301521 1.8026217693837 0.65625 18.3 18 3 abnormal pulmonary artery morphology 0.000122535356253257 0.00202529367893673 1.79142536087821 0.652173913043478 18.3 18 3 kidney failure 1.49684680586139e-07 6.36479731552171e-06 1.78864795721793 0.651162790697674 18.3 18 3 abnormal vascular regression 0.000371180290646226 0.00492432518923993 1.78545394300861 0.65 18.3 18 3 increased mammary adenocarcinoma incidence 0.000371180290646226 0.00492432518923993 1.78545394300861 0.65 18.3 18 3 anencephaly 0.000371180290646226 0.00492432518923993 1.78545394300861 0.65 18.3 18 3 absent placental labyrinth 0.000371180290646226 0.00492432518923993 1.78545394300861 0.65 18.3 18 3 absent ductus venosus valve 0.000371180290646226 0.00492432518923993 1.78545394300861 0.65 18.3 18 3 failure of chorioallantoic fusion 1.46798121721452e-08 8.11467395071358e-07 1.77737496589093 0.647058823529412 18.3 18 3 abnormal adipose tissue morphology 0.00113482241953419 0.0123810121429443 1.77737496589093 0.647058823529412 18.3 18 3 abnormal dorsal-ventral axis patterning 0.00113482241953419 0.0123810121429443 1.77737496589093 0.647058823529412 18.3 18 3 abnormal embryonic-extraembryonic boundary morphology 0.00113482241953419 0.0123810121429443 1.77737496589093 0.647058823529412 18.3 18 3 abnormal ectoplacental cone morphology 0.00113482241953419 0.0123810121429443 1.77737496589093 0.647058823529412 18.3 18 3 increased brain size 0.00113482241953419 0.0123810121429443 1.77737496589093 0.647058823529412 18.3 18 3 vertebral transformation 4.29319849424205e-08 2.0939865204759e-06 1.77400872542523 0.645833333333333 18.3 18 3 pale kidney 1.13745420631023e-05 0.00027604071592163 1.7721627225892 0.645161290322581 18.3 18 3 abnormal cell cycle 3.00078967966422e-17 7.85733087175237e-15 1.76753968939983 0.643478260869565 18.3 18 3 translucent skin 0.00351338035166732 0.0309982176848279 1.76583357000852 0.642857142857143 18.3 18 3 irregularly shaped pupil 0.00351338035166732 0.0309982176848279 1.76583357000852 0.642857142857143 18.3 18 3 increased aggression towards males 0.00351338035166732 0.0309982176848279 1.76583357000852 0.642857142857143 18.3 18 3 increased hemangioma incidence 0.00351338035166732 0.0309982176848279 1.76583357000852 0.642857142857143 18.3 18 3 premature hair loss 0.00351338035166732 0.0309982176848279 1.76583357000852 0.642857142857143 18.3 18 3 spina bifida occulta 0.00351338035166732 0.0309982176848279 1.76583357000852 0.642857142857143 18.3 18 3 ruffled hair 0.000101120770318113 0.00175287746457357 1.75798542080848 0.64 18.3 18 3 aphakia 0.000303781220250702 0.00423336574439003 1.74799686728116 0.636363636363636 18.3 18 3 abnormal sphenoid bone morphology 0.0110745477246547 0.0717394204819755 1.74799686728116 0.636363636363636 18.3 18 3 delayed hepatic development 0.0110745477246547 0.0717394204819755 1.74799686728116 0.636363636363636 18.3 18 3 abnormal larynx morphology 0.0110745477246547 0.0717394204819755 1.74799686728116 0.636363636363636 18.3 18 3 abnormal bronchiole morphology 0.0110745477246547 0.0717394204819755 1.74799686728116 0.636363636363636 18.3 18 3 fatigue 0.0110745477246547 0.0717394204819755 1.74799686728116 0.636363636363636 18.3 18 3 retinal detachment 0.0110745477246547 0.0717394204819755 1.74799686728116 0.636363636363636 18.3 18 3 abnormal spinal cord ventral horn morphology 0.0110745477246547 0.0717394204819755 1.74799686728116 0.636363636363636 18.3 18 3 increased glycogen level 0.0110745477246547 0.0717394204819755 1.74799686728116 0.636363636363636 18.3 18 3 palatal shelf hypoplasia 0.0110745477246547 0.0717394204819755 1.74799686728116 0.636363636363636 18.3 18 3 common atrioventricular valve 0.0110745477246547 0.0717394204819755 1.74799686728116 0.636363636363636 18.3 18 3 persistence of hyaloid vascular system 2.6297273137317e-06 7.83406789569774e-05 1.73485403369258 0.631578947368421 18.3 18 3 abnormal triglyceride level 0.000918769476818173 0.0103883594253873 1.73485403369258 0.631578947368421 18.3 18 3 increased liver cholesterol level 0.000918769476818173 0.0103883594253873 1.73485403369258 0.631578947368421 18.3 18 3 embryonic lethality between implantation and somite formation, incomplete penetrance 0.000918769476818173 0.0103883594253873 1.73485403369258 0.631578947368421 18.3 18 3 embryonic lethality between implantation and placentation, complete penetrance 2.53227218457273e-07 9.84222977988228e-06 1.73171118218227 0.630434782608696 18.3 18 3 abnormal liver development 7.72052647751968e-06 0.000200050100133648 1.72659282400833 0.628571428571429 18.3 18 3 thick pulmonary interalveolar septum 7.72052647751968e-06 0.000200050100133648 1.72659282400833 0.628571428571429 18.3 18 3 increased carcinoma incidence 7.72052647751968e-06 0.000200050100133648 1.72659282400833 0.628571428571429 18.3 18 3 decreased glycogen level 7.72052647751968e-06 0.000200050100133648 1.72659282400833 0.628571428571429 18.3 18 3 enlarged pituitary gland 0.0358912562040724 0.163216635845759 1.71678263750828 0.625 18.3 18 3 abnormal pupil morphology 0.0358912562040724 0.163216635845759 1.71678263750828 0.625 18.3 18 3 absent eyelids 0.0358912562040724 0.163216635845759 1.71678263750828 0.625 18.3 18 3 poor grooming 0.0358912562040724 0.163216635845759 1.71678263750828 0.625 18.3 18 3 abnormal urination 0.0358912562040724 0.163216635845759 1.71678263750828 0.625 18.3 18 3 preneoplasia 0.0358912562040724 0.163216635845759 1.71678263750828 0.625 18.3 18 3 vascular smooth muscle hypertrophy 0.0358912562040724 0.163216635845759 1.71678263750828 0.625 18.3 18 3 short ureter 0.0358912562040724 0.163216635845759 1.71678263750828 0.625 18.3 18 3 altered response to CNS ischemic injury 0.0358912562040724 0.163216635845759 1.71678263750828 0.625 18.3 18 3 hypospadia 0.0358912562040724 0.163216635845759 1.71678263750828 0.625 18.3 18 3 abnormal neuron apoptosis 0.0358912562040724 0.163216635845759 1.71678263750828 0.625 18.3 18 3 loss of GABAergic neurons 0.0358912562040724 0.163216635845759 1.71678263750828 0.625 18.3 18 3 colon polyps 0.0358912562040724 0.163216635845759 1.71678263750828 0.625 18.3 18 3 abnormal perineum morphology 0.0358912562040724 0.163216635845759 1.71678263750828 0.625 18.3 18 3 increased cardiac output 0.0358912562040724 0.163216635845759 1.71678263750828 0.625 18.3 18 3 elevated level of mitotic sister chromatid exchange 0.0358912562040724 0.163216635845759 1.71678263750828 0.625 18.3 18 3 bowed fibula 0.0358912562040724 0.163216635845759 1.71678263750828 0.625 18.3 18 3 accumulation of giant lysosomes in kidney/renal tubule cells 0.0358912562040724 0.163216635845759 1.71678263750828 0.625 18.3 18 3 ectrodactyly 0.0358912562040724 0.163216635845759 1.71678263750828 0.625 18.3 18 3 craniofacial phenotype 0.0358912562040724 0.163216635845759 1.71678263750828 0.625 18.3 18 3 stomach epithelial hyperplasia 0.0358912562040724 0.163216635845759 1.71678263750828 0.625 18.3 18 3 abnormal frontonasal prominence morphology 0.0358912562040724 0.163216635845759 1.71678263750828 0.625 18.3 18 3 abnormal heart right ventricle pressure 0.0358912562040724 0.163216635845759 1.71678263750828 0.625 18.3 18 3 decreased alveolar lamellar body number 0.0358912562040724 0.163216635845759 1.71678263750828 0.625 18.3 18 3 absent ureteric bud 0.0358912562040724 0.163216635845759 1.71678263750828 0.625 18.3 18 3 increased circulating ferritin level 0.0358912562040724 0.163216635845759 1.71678263750828 0.625 18.3 18 3 increased hemangiosarcoma incidence 0.000246047412739131 0.00356876349381101 1.71678263750828 0.625 18.3 18 3 abnormal myocardial trabeculae morphology 6.04309966057106e-07 2.13222842633624e-05 1.70915249245269 0.622222222222222 18.3 18 3 increased cellular sensitivity to gamma-irradiation 4.92268209451851e-07 1.78761630804596e-05 1.69486626341243 0.617021276595745 18.3 18 3 eyelids open at birth 1.38561531619814e-07 5.94261741214287e-06 1.69037059693123 0.615384615384615 18.3 18 3 abnormal ocular fundus morphology 0.000197730693976893 0.00304554242270911 1.69037059693123 0.615384615384615 18.3 18 3 absent common myeloid progenitor cells 0.00865166479750241 0.0597806005105201 1.69037059693123 0.615384615384615 18.3 18 3 absent myocardial trabeculae 0.00865166479750241 0.0597806005105201 1.69037059693123 0.615384615384615 18.3 18 3 absent trabeculae carneae 0.00865166479750241 0.0597806005105201 1.69037059693123 0.615384615384615 18.3 18 3 increased pituitary adenoma incidence 0.00865166479750241 0.0597806005105201 1.69037059693123 0.615384615384615 18.3 18 3 abnormal tail bud morphology 0.00865166479750241 0.0597806005105201 1.69037059693123 0.615384615384615 18.3 18 3 abnormal coping response 0.00865166479750241 0.0597806005105201 1.69037059693123 0.615384615384615 18.3 18 3 abnormal circulating amino acid level 3.91296813706157e-08 1.92742737444369e-06 1.68666364386779 0.614035087719298 18.3 18 3 decreased thymus weight 5.3889744827017e-05 0.00106813338850362 1.68355458645974 0.612903225806452 18.3 18 3 abnormal trophoblast giant cell morphology 1.48419643480894e-05 0.000340270841620945 1.67863191223032 0.611111111111111 18.3 18 3 abnormal mitral valve morphology 0.00221545220487138 0.0214016984839517 1.67863191223032 0.611111111111111 18.3 18 3 absent ureter 0.00221545220487138 0.0214016984839517 1.67863191223032 0.611111111111111 18.3 18 3 abnormal pregnancy 0.00221545220487138 0.0214016984839517 1.67863191223032 0.611111111111111 18.3 18 3 small thoracic cage 0.00221545220487138 0.0214016984839517 1.67863191223032 0.611111111111111 18.3 18 3 increased effector memory CD4-positive, alpha-beta T cell number 0.00221545220487138 0.0214016984839517 1.67863191223032 0.611111111111111 18.3 18 3 microcephaly 2.55216083385168e-09 1.7158108308665e-07 1.67199700348633 0.608695652173913 18.3 18 3 abnormal placenta morphology 2.06706308407922e-10 1.67186497923483e-08 1.66897350076755 0.607594936708861 18.3 18 3 enlarged pericardium 4.31695246562015e-05 0.000883820515080669 1.66475892122015 0.606060606060606 18.3 18 3 impaired branching involved in ureteric bud morphogenesis 1.1914041811587e-05 0.000287729893265269 1.66256844895539 0.605263157894737 18.3 18 3 overriding aortic valve 9.26051719278076e-07 3.05106443934333e-05 1.65955654959134 0.604166666666667 18.3 18 3 abnormal axon morphology 2.58308884939126e-13 3.6716762930633e-11 1.65319809537835 0.601851851851852 18.3 18 3 increased B cell derived lymphoma incidence 7.43142959255989e-07 2.54974911882658e-05 1.64811133200795 0.6 18.3 18 3 increased circulating chloride level 7.43142959255989e-07 2.54974911882658e-05 1.64811133200795 0.6 18.3 18 3 abnormal keratinocyte physiology 0.000463437376370657 0.00600416913396879 1.64811133200795 0.6 18.3 18 3 abnormal erythropoiesis 7.28541745315504e-13 9.79593292687738e-11 1.64811133200795 0.6 18.3 18 3 abnormal embryo turning 2.08967464297408e-07 8.45213930796428e-06 1.64811133200795 0.6 18.3 18 3 absent incisors 0.00671171366218702 0.0490319757259624 1.64811133200795 0.6 18.3 18 3 audiogenic seizures 0.00671171366218702 0.0490319757259624 1.64811133200795 0.6 18.3 18 3 abnormal placenta size 0.00671171366218702 0.0490319757259624 1.64811133200795 0.6 18.3 18 3 abnormal trophectoderm morphology 0.00671171366218702 0.0490319757259624 1.64811133200795 0.6 18.3 18 3 immune system phenotype 0.00671171366218702 0.0490319757259624 1.64811133200795 0.6 18.3 18 3 abnormal cerebral aqueduct morphology 0.00671171366218702 0.0490319757259624 1.64811133200795 0.6 18.3 18 3 decreased thymocyte apoptosis 0.00671171366218702 0.0490319757259624 1.64811133200795 0.6 18.3 18 3 bicuspid aortic valve 0.00671171366218702 0.0490319757259624 1.64811133200795 0.6 18.3 18 3 abnormal branching involved in lung morphogenesis 0.00671171366218702 0.0490319757259624 1.64811133200795 0.6 18.3 18 3 heterochrony 0.00671171366218702 0.0490319757259624 1.64811133200795 0.6 18.3 18 3 abnormal otic capsule morphology 0.0271392786086655 0.13302257249075 1.64811133200795 0.6 18.3 18 3 abnormal auchene hair morphology 0.0271392786086655 0.13302257249075 1.64811133200795 0.6 18.3 18 3 retarded hair growth 0.0271392786086655 0.13302257249075 1.64811133200795 0.6 18.3 18 3 jaundice 0.0271392786086655 0.13302257249075 1.64811133200795 0.6 18.3 18 3 enlarged testis 0.0271392786086655 0.13302257249075 1.64811133200795 0.6 18.3 18 3 abnormal mammary gland physiology 0.0271392786086655 0.13302257249075 1.64811133200795 0.6 18.3 18 3 abnormal tibialis anterior morphology 0.0271392786086655 0.13302257249075 1.64811133200795 0.6 18.3 18 3 absent seminal vesicle 0.0271392786086655 0.13302257249075 1.64811133200795 0.6 18.3 18 3 abnormal submandibular gland morphology 0.0271392786086655 0.13302257249075 1.64811133200795 0.6 18.3 18 3 abnormal pillar cell morphology 0.0271392786086655 0.13302257249075 1.64811133200795 0.6 18.3 18 3 abnormal placental transport 0.0271392786086655 0.13302257249075 1.64811133200795 0.6 18.3 18 3 abnormal inferior vena cava valve morphology 0.0271392786086655 0.13302257249075 1.64811133200795 0.6 18.3 18 3 thick aortic valve 0.0271392786086655 0.13302257249075 1.64811133200795 0.6 18.3 18 3 lethality during fetal growth through weaning, complete penetrance 0.0271392786086655 0.13302257249075 1.64811133200795 0.6 18.3 18 3 decreased circulating lactate level 0.0271392786086655 0.13302257249075 1.64811133200795 0.6 18.3 18 3 abnormal extraembryonic tissue morphology 2.05214316125365e-12 2.37428191331091e-10 1.64272534726283 0.598039215686274 18.3 18 3 abnormal cell morphology 1.35580067651743e-13 2.17584140828201e-11 1.63847325404299 0.596491228070175 18.3 18 3 increased hepatocellular carcinoma incidence 1.67475970031463e-07 6.88589215625231e-06 1.63847325404299 0.596491228070175 18.3 18 3 kidney cysts 3.05157459459353e-09 1.97163423481855e-07 1.63326348217004 0.594594594594595 18.3 18 3 kidney cortex cysts 9.94630656075778e-05 0.00173017045943252 1.63094350563287 0.59375 18.3 18 3 abnormal spongiotrophoblast layer morphology 9.94630656075778e-05 0.00173017045943252 1.63094350563287 0.59375 18.3 18 3 increased fibroblast apoptosis 9.94630656075778e-05 0.00173017045943252 1.63094350563287 0.59375 18.3 18 3 abnormal fetal cardiomyocyte proliferation 0.000365197775049222 0.00492432518923993 1.62776427852637 0.592592592592593 18.3 18 3 decreased circulating fructosamine level 0.000365197775049222 0.00492432518923993 1.62776427852637 0.592592592592593 18.3 18 3 abnormal abdominal fat pad morphology 0.00136099418756478 0.0144062682619889 1.62313994818965 0.590909090909091 18.3 18 3 abnormal germ layer development 0.00136099418756478 0.0144062682619889 1.62313994818965 0.590909090909091 18.3 18 3 abnormal basement membrane morphology 0.00136099418756478 0.0144062682619889 1.62313994818965 0.590909090909091 18.3 18 3 increased incidence of corneal inflammation 0.00518622822796276 0.0410973397471492 1.61579542353721 0.588235294117647 18.3 18 3 hyperlipidemia 0.00518622822796276 0.0410973397471492 1.61579542353721 0.588235294117647 18.3 18 3 aminoaciduria 0.00518622822796276 0.0410973397471492 1.61579542353721 0.588235294117647 18.3 18 3 increased hepatoma incidence 0.00518622822796276 0.0410973397471492 1.61579542353721 0.588235294117647 18.3 18 3 abnormal trophoblast layer morphology 1.34364243636383e-06 4.2850135390449e-05 1.61579542353721 0.588235294117647 18.3 18 3 lordosis 0.000286889819589244 0.00405476378538775 1.61022371518018 0.586206896551724 18.3 18 3 abnormal outer ear morphology 0.000286889819589244 0.00405476378538775 1.61022371518018 0.586206896551724 18.3 18 3 polychromatophilia 0.000286889819589244 0.00405476378538775 1.61022371518018 0.586206896551724 18.3 18 3 palatal shelves fail to meet at midline 1.71634637515185e-05 0.000389900603487692 1.6079134946419 0.585365853658537 18.3 18 3 enlarged kidney 1.06633491321383e-06 3.44481570989533e-05 1.60664941170587 0.584905660377358 18.3 18 3 abnormal pharyngeal arch morphology 6.18723090072414e-05 0.00117936680962079 1.6023304616744 0.583333333333333 18.3 18 3 renal hypoplasia 6.18723090072414e-05 0.00117936680962079 1.6023304616744 0.583333333333333 18.3 18 3 abnormal body weight 0.00106125977635736 0.0117589474106411 1.6023304616744 0.583333333333333 18.3 18 3 blindness 0.00106125977635736 0.0117589474106411 1.6023304616744 0.583333333333333 18.3 18 3 hypopigmentation 0.00106125977635736 0.0117589474106411 1.6023304616744 0.583333333333333 18.3 18 3 abnormal mineral level 0.0205039142532651 0.106925548647792 1.6023304616744 0.583333333333333 18.3 18 3 amyloidosis 0.0205039142532651 0.106925548647792 1.6023304616744 0.583333333333333 18.3 18 3 absent optic nerve 0.0205039142532651 0.106925548647792 1.6023304616744 0.583333333333333 18.3 18 3 altered tumor susceptibility 0.0205039142532651 0.106925548647792 1.6023304616744 0.583333333333333 18.3 18 3 abnormal vascular endothelial cell development 0.0205039142532651 0.106925548647792 1.6023304616744 0.583333333333333 18.3 18 3 pale placenta 0.0205039142532651 0.106925548647792 1.6023304616744 0.583333333333333 18.3 18 3 abnormal fatty acid level 0.0205039142532651 0.106925548647792 1.6023304616744 0.583333333333333 18.3 18 3 decreased renal glomerular filtration rate 0.0205039142532651 0.106925548647792 1.6023304616744 0.583333333333333 18.3 18 3 abnormal pulmonary valve cusp morphology 0.0205039142532651 0.106925548647792 1.6023304616744 0.583333333333333 18.3 18 3 prenatal growth retardation 0.0205039142532651 0.106925548647792 1.6023304616744 0.583333333333333 18.3 18 3 abnormal vitelline vein connection 0.0205039142532651 0.106925548647792 1.6023304616744 0.583333333333333 18.3 18 3 abnormal eye morphology 4.2308962361352e-15 7.51739599099021e-13 1.60068366777751 0.58273381294964 18.3 18 3 delayed endochondral bone ossification 1.35456480206849e-05 0.000320902851918606 1.59700710465887 0.581395348837209 18.3 18 3 abnormal double-strand DNA break repair 1.35456480206849e-05 0.000320902851918606 1.59700710465887 0.581395348837209 18.3 18 3 increased tumor incidence 1.7720704741403e-13 2.6715304875297e-11 1.59494645033028 0.580645161290323 18.3 18 3 abnormal eyelid morphology 0.000224830045979692 0.00331907857195539 1.59494645033028 0.580645161290323 18.3 18 3 abnormal object recognition memory 0.000224830045979692 0.00331907857195539 1.59494645033028 0.580645161290323 18.3 18 3 abnormal nose morphology 0.000224830045979692 0.00331907857195539 1.59494645033028 0.580645161290323 18.3 18 3 increased malignant tumor incidence 0.00399839095594454 0.0344152162730521 1.5902828642182 0.578947368421053 18.3 18 3 abnormal digestive system development 0.00399839095594454 0.0344152162730521 1.5902828642182 0.578947368421053 18.3 18 3 decreased eye pigmentation 0.00399839095594454 0.0344152162730521 1.5902828642182 0.578947368421053 18.3 18 3 trabecula carnea hypoplasia 1.06718987984303e-05 0.000262304967747691 1.58707017156321 0.577777777777778 18.3 18 3 corneal opacity 3.37787251850898e-08 1.68049157795822e-06 1.58621043690906 0.577464788732394 18.3 18 3 abnormal nerve conduction 0.000825764670543976 0.0094591057911056 1.58472243462303 0.576923076923077 18.3 18 3 increased thymocyte apoptosis 0.000825764670543976 0.0094591057911056 1.58472243462303 0.576923076923077 18.3 18 3 single kidney 0.000175861442613018 0.00275997058990462 1.58152097515915 0.575757575757576 18.3 18 3 abnormal cell nucleus morphology 8.39533634921456e-06 0.000214188709422269 1.57797893490123 0.574468085106383 18.3 18 3 abnormal chondrocyte morphology 1.86353469435719e-06 5.7944281902669e-05 1.57689664482242 0.574074074074074 18.3 18 3 increased T cell derived lymphoma incidence 6.59595947412829e-06 0.000177377829101558 1.56962984000757 0.571428571428571 18.3 18 3 abnormal craniofacial development 6.59595947412829e-06 0.000177377829101558 1.56962984000757 0.571428571428571 18.3 18 3 abnormal embryonic epiblast morphology 0.000137351743325028 0.00221858741247407 1.56962984000757 0.571428571428571 18.3 18 3 abnormal hippocampus pyramidal cell morphology 0.000137351743325028 0.00221858741247407 1.56962984000757 0.571428571428571 18.3 18 3 lymphoid hyperplasia 0.000641531798085138 0.00770922873302793 1.56962984000757 0.571428571428571 18.3 18 3 abnormal mitotic spindle morphology 0.000641531798085138 0.00770922873302793 1.56962984000757 0.571428571428571 18.3 18 3 abnormal hematopoietic system physiology 0.003078654351975 0.0279494624107219 1.56962984000757 0.571428571428571 18.3 18 3 abnormal embryonic/fetal subventricular zone morphology 0.003078654351975 0.0279494624107219 1.56962984000757 0.571428571428571 18.3 18 3 embryonic lethality at implantation, complete penetrance 0.003078654351975 0.0279494624107219 1.56962984000757 0.571428571428571 18.3 18 3 increased muscle cell glucose uptake 0.003078654351975 0.0279494624107219 1.56962984000757 0.571428571428571 18.3 18 3 abnormal interparietal bone morphology 0.0155027107252825 0.0930349648471417 1.56962984000757 0.571428571428571 18.3 18 3 absent visceral yolk sac blood islands 0.0155027107252825 0.0930349648471417 1.56962984000757 0.571428571428571 18.3 18 3 abnormal maternal decidual layer morphology 0.0155027107252825 0.0930349648471417 1.56962984000757 0.571428571428571 18.3 18 3 split sternum 0.0155027107252825 0.0930349648471417 1.56962984000757 0.571428571428571 18.3 18 3 lysosomal protein accumulation 0.0155027107252825 0.0930349648471417 1.56962984000757 0.571428571428571 18.3 18 3 increased circulating growth hormone level 0.0155027107252825 0.0930349648471417 1.56962984000757 0.571428571428571 18.3 18 3 decreased tongue size 0.0155027107252825 0.0930349648471417 1.56962984000757 0.571428571428571 18.3 18 3 abnormal renal reabsorbtion 0.0155027107252825 0.0930349648471417 1.56962984000757 0.571428571428571 18.3 18 3 abnormal amino acid level 2.34223972669624e-05 0.000504443404342589 1.56071148864389 0.568181818181818 18.3 18 3 decreased cell proliferation 5.51982393916125e-18 1.61536024101925e-15 1.5590242329805 0.567567567567568 18.3 18 3 increased circulating phosphate level 0.000107145937479281 0.00181325348800643 1.5590242329805 0.567567567567568 18.3 18 3 decreased width of hypertrophic chondrocyte zone 0.000107145937479281 0.00181325348800643 1.5590242329805 0.567567567567568 18.3 18 3 abnormal hair follicle development 0.000107145937479281 0.00181325348800643 1.5590242329805 0.567567567567568 18.3 18 3 embryonic lethality, complete penetrance 6.54464196110874e-30 3.61773263961289e-27 1.55855878314232 0.567398119122257 18.3 18 3 embryonic lethality between implantation and somite formation, complete penetrance 2.65690560078208e-23 1.20164594217189e-20 1.55841819829323 0.56734693877551 18.3 18 3 abnormal kidney development 9.05930544852248e-07 3.00466964042662e-05 1.55654959134084 0.566666666666667 18.3 18 3 absent mesoderm 9.05930544852248e-07 3.00466964042662e-05 1.55654959134084 0.566666666666667 18.3 18 3 abnormal brain vasculature morphology 0.000497840769576719 0.00639989103008831 1.55654959134084 0.566666666666667 18.3 18 3 abnormal allantois morphology 1.83176251779825e-05 0.000412983593779762 1.55256864609445 0.565217391304348 18.3 18 3 abnormal hematopoietic stem cell physiology 0.00236885163121158 0.0224476892671954 1.55256864609445 0.565217391304348 18.3 18 3 perimembraneous ventricular septal defect 1.59860792678837e-07 6.68325582837993e-06 1.55256864609445 0.565217391304348 18.3 18 3 abnormal lung development 6.43523909932787e-09 3.90430664867758e-07 1.55116360659572 0.564705882352941 18.3 18 3 abnormal iris morphology 8.3502012357285e-05 0.00149972025804149 1.5495063805203 0.564102564102564 18.3 18 3 small heart 1.43133646036243e-05 0.000332752284593603 1.54510437375746 0.5625 18.3 18 3 polydipsia 0.000386016163600977 0.00509397987775826 1.54510437375746 0.5625 18.3 18 3 vasculature congestion 0.0117371405041608 0.0747660358619719 1.54510437375746 0.5625 18.3 18 3 delayed hair appearance 0.0117371405041608 0.0747660358619719 1.54510437375746 0.5625 18.3 18 3 disorganized retinal layers 0.0117371405041608 0.0747660358619719 1.54510437375746 0.5625 18.3 18 3 disorganized yolk sac vascular plexus 0.0117371405041608 0.0747660358619719 1.54510437375746 0.5625 18.3 18 3 abnormal olfaction 0.0117371405041608 0.0747660358619719 1.54510437375746 0.5625 18.3 18 3 increased thymus weight 0.0117371405041608 0.0747660358619719 1.54510437375746 0.5625 18.3 18 3 dystonia 0.0117371405041608 0.0747660358619719 1.54510437375746 0.5625 18.3 18 3 decreased circulating triiodothyronine level 0.0117371405041608 0.0747660358619719 1.54510437375746 0.5625 18.3 18 3 decreased liver cholesterol level 0.0117371405041608 0.0747660358619719 1.54510437375746 0.5625 18.3 18 3 increased heart left ventricle size 0.0117371405041608 0.0747660358619719 1.54510437375746 0.5625 18.3 18 3 abnormal pulmonary alveolus wall morphology 0.0117371405041608 0.0747660358619719 1.54510437375746 0.5625 18.3 18 3 anophthalmia 3.9810431294516e-09 2.5070493125344e-07 1.54317540450183 0.561797752808989 18.3 18 3 incomplete embryo turning 2.48881289816584e-06 7.45894227010546e-05 1.54209247439341 0.56140350877193 18.3 18 3 abnormal craniofacial bone morphology 2.48881289816584e-06 7.45894227010546e-05 1.54209247439341 0.56140350877193 18.3 18 3 double outlet right ventricle 1.28033822594237e-10 1.15812412255696e-08 1.54029096449341 0.560747663551402 18.3 18 3 decreased embryo size 2.2808696156734e-42 3.78244211265839e-39 1.54007614009111 0.560669456066946 18.3 18 3 increased cellular sensitivity to ionizing radiation 0.0018221246490677 0.0184249392868127 1.53823724320742 0.56 18.3 18 3 short maxilla 0.000299130385089307 0.00418026310623399 1.53500565236035 0.558823529411765 18.3 18 3 enlarged liver sinusoidal spaces 0.000299130385089307 0.00418026310623399 1.53500565236035 0.558823529411765 18.3 18 3 increased circulating creatinine level 1.07941499710961e-08 6.17251679381646e-07 1.53312682047251 0.558139534883721 18.3 18 3 abnormal vasculogenesis 5.06036924518174e-05 0.00101513455624109 1.53312682047251 0.558139534883721 18.3 18 3 abnormal homeostasis 5.06036924518174e-05 0.00101513455624109 1.53312682047251 0.558139534883721 18.3 18 3 abnormal snout morphology 8.72160300059646e-06 0.000219141287514987 1.53189835346893 0.557692307692308 18.3 18 3 kinked neural tube 8.72160300059646e-06 0.000219141287514987 1.53189835346893 0.557692307692308 18.3 18 3 embryonic lethality between somite formation and embryo turning, complete penetrance 2.68058924446745e-07 1.03379313885469e-05 1.53038909400738 0.557142857142857 18.3 18 3 abnormal maxilla morphology 6.8023702068412e-06 0.000180972148550989 1.52602901111847 0.555555555555556 18.3 18 3 abnormal cell adhesion 6.8023702068412e-06 0.000180972148550989 1.52602901111847 0.555555555555556 18.3 18 3 narrow eye opening 0.000231701036222259 0.00339033133884041 1.52602901111847 0.555555555555556 18.3 18 3 abnormal trigeminal ganglion morphology 0.00140147328991241 0.0146477512968787 1.52602901111847 0.555555555555556 18.3 18 3 thin epidermis 0.00140147328991241 0.0146477512968787 1.52602901111847 0.555555555555556 18.3 18 3 increased brain weight 0.00140147328991241 0.0146477512968787 1.52602901111847 0.555555555555556 18.3 18 3 underdeveloped hair follicles 0.00889969825682699 0.0605690818436584 1.52602901111847 0.555555555555556 18.3 18 3 abnormal thyroid cartilage morphology 0.00889969825682699 0.0605690818436584 1.52602901111847 0.555555555555556 18.3 18 3 abnormal metacarpal bone morphology 0.00889969825682699 0.0605690818436584 1.52602901111847 0.555555555555556 18.3 18 3 absent inner cell mass 0.00889969825682699 0.0605690818436584 1.52602901111847 0.555555555555556 18.3 18 3 darkened coat color 0.00889969825682699 0.0605690818436584 1.52602901111847 0.555555555555556 18.3 18 3 abnormal glycogen homeostasis 0.00889969825682699 0.0605690818436584 1.52602901111847 0.555555555555556 18.3 18 3 decreased lactate dehydrogenase level 0.00889969825682699 0.0605690818436584 1.52602901111847 0.555555555555556 18.3 18 3 decreased tumor latency 0.00889969825682699 0.0605690818436584 1.52602901111847 0.555555555555556 18.3 18 3 primary atelectasis 0.00889969825682699 0.0605690818436584 1.52602901111847 0.555555555555556 18.3 18 3 increased effector memory CD8-positive, alpha-beta T cell number 0.00889969825682699 0.0605690818436584 1.52602901111847 0.555555555555556 18.3 18 3 abnormal hypoglossal nerve topology 0.00889969825682699 0.0605690818436584 1.52602901111847 0.555555555555556 18.3 18 3 heart hyperplasia 0.0632638857387578 0.237001379179458 1.52602901111847 0.555555555555556 18.3 18 3 crypts of Lieberkuhn abscesses 0.0632638857387578 0.237001379179458 1.52602901111847 0.555555555555556 18.3 18 3 abnormal urinary bladder urothelium morphology 0.0632638857387578 0.237001379179458 1.52602901111847 0.555555555555556 18.3 18 3 synostosis 0.0632638857387578 0.237001379179458 1.52602901111847 0.555555555555556 18.3 18 3 abnormal lens vesicle development 0.0632638857387578 0.237001379179458 1.52602901111847 0.555555555555556 18.3 18 3 abnormal ion homeostasis 0.0632638857387578 0.237001379179458 1.52602901111847 0.555555555555556 18.3 18 3 decreased fear-related response 0.0632638857387578 0.237001379179458 1.52602901111847 0.555555555555556 18.3 18 3 abnormal ovary physiology 0.0632638857387578 0.237001379179458 1.52602901111847 0.555555555555556 18.3 18 3 decreased cochlear hair cell number 0.0632638857387578 0.237001379179458 1.52602901111847 0.555555555555556 18.3 18 3 increased neuronal precursor cell number 0.0632638857387578 0.237001379179458 1.52602901111847 0.555555555555556 18.3 18 3 abnormal intervertebral disk development 0.0632638857387578 0.237001379179458 1.52602901111847 0.555555555555556 18.3 18 3 abnormal inguinal fat pad morphology 0.0632638857387578 0.237001379179458 1.52602901111847 0.555555555555556 18.3 18 3 abnormal optic chiasm morphology 0.0632638857387578 0.237001379179458 1.52602901111847 0.555555555555556 18.3 18 3 axonal spheroids 0.0632638857387578 0.237001379179458 1.52602901111847 0.555555555555556 18.3 18 3 abnormal ventricle myocardium morphology 0.0632638857387578 0.237001379179458 1.52602901111847 0.555555555555556 18.3 18 3 iris coloboma 0.0632638857387578 0.237001379179458 1.52602901111847 0.555555555555556 18.3 18 3 abnormal lung lobe morphology 0.0632638857387578 0.237001379179458 1.52602901111847 0.555555555555556 18.3 18 3 increased core body temperature 0.0632638857387578 0.237001379179458 1.52602901111847 0.555555555555556 18.3 18 3 increased myeloid cell number 0.0632638857387578 0.237001379179458 1.52602901111847 0.555555555555556 18.3 18 3 trigeminal neuroma 0.0632638857387578 0.237001379179458 1.52602901111847 0.555555555555556 18.3 18 3 abnormal infrahyoid muscle connection 0.0632638857387578 0.237001379179458 1.52602901111847 0.555555555555556 18.3 18 3 abnormal coronary sinus connection 0.0632638857387578 0.237001379179458 1.52602901111847 0.555555555555556 18.3 18 3 decreased fatty acid oxidation 0.0632638857387578 0.237001379179458 1.52602901111847 0.555555555555556 18.3 18 3 cerebellum atrophy 0.0632638857387578 0.237001379179458 1.52602901111847 0.555555555555556 18.3 18 3 increased endoplasmic reticulum stress 0.0632638857387578 0.237001379179458 1.52602901111847 0.555555555555556 18.3 18 3 decreased leukocyte cell number 9.79262345697929e-13 1.24918722303774e-10 1.5238012315402 0.554744525547445 18.3 18 3 pallor 8.23345038980573e-16 1.63845662757134e-13 1.52254094480735 0.554285714285714 18.3 18 3 pale liver 1.64067628865388e-07 6.80197044671086e-06 1.52190460838572 0.554054054054054 18.3 18 3 lethality throughout fetal growth and development, incomplete penetrance 5.07651761700054e-16 1.09807283237294e-13 1.519208769728 0.553072625698324 18.3 18 3 incomplete somite formation 0.0001794164736308 0.00280690866765166 1.51799727948101 0.552631578947368 18.3 18 3 decreased trophoblast giant cell number 0.00107801423315701 0.011918046244347 1.51550467311076 0.551724137931034 18.3 18 3 small liver 1.00256854502001e-07 4.41396328449076e-06 1.51429032641756 0.551282051282051 18.3 18 3 increased sarcoma incidence 2.37847254443697e-05 0.000510038832266117 1.51357163143587 0.551020408163265 18.3 18 3 decreased spleen weight 5.66143817412922e-07 2.02630610908582e-05 1.51275919363049 0.550724637681159 18.3 18 3 dilated vasculature 0.00675845925578376 0.0493010774157247 1.51076872100729 0.55 18.3 18 3 small lung 1.84806723302362e-05 0.000414150201995157 1.50807572863473 0.549019607843137 18.3 18 3 hypoglycemia 8.5320507808349e-09 4.93569216682019e-07 1.50633831420082 0.548387096774194 18.3 18 3 abnormal vitelline vasculature morphology 1.68233024223887e-10 1.4430332681273e-08 1.5047973031377 0.547826086956522 18.3 18 3 abnormal optic nerve morphology 0.00010751955356018 0.00181325348800643 1.50422859667392 0.547619047619048 18.3 18 3 skin edema 0.00010751955356018 0.00181325348800643 1.50422859667392 0.547619047619048 18.3 18 3 abnormal pancreas morphology 0.00010751955356018 0.00181325348800643 1.50422859667392 0.547619047619048 18.3 18 3 abnormal brain morphology 5.27537727400366e-14 9.05000066833387e-12 1.50138506435507 0.546583850931677 18.3 18 3 embryonic growth arrest 3.38546970311226e-19 1.20305084092739e-16 1.49937348253999 0.54585152838428 18.3 18 3 muscular atrophy 8.32212466736433e-05 0.00149972025804149 1.49828302909814 0.545454545454545 18.3 18 3 abnormal tooth development 0.000638201828786533 0.00770644198595389 1.49828302909814 0.545454545454545 18.3 18 3 abnormal epidermis stratum basale morphology 0.000638201828786533 0.00770644198595389 1.49828302909814 0.545454545454545 18.3 18 3 diarrhea 0.000638201828786533 0.00770644198595389 1.49828302909814 0.545454545454545 18.3 18 3 abnormal enterocyte morphology 0.00513984654926725 0.0410973397471492 1.49828302909814 0.545454545454545 18.3 18 3 abnormal facial nerve morphology 0.00513984654926725 0.0410973397471492 1.49828302909814 0.545454545454545 18.3 18 3 abnormal chorion morphology 0.00513984654926725 0.0410973397471492 1.49828302909814 0.545454545454545 18.3 18 3 increased coping response 0.00513984654926725 0.0410973397471492 1.49828302909814 0.545454545454545 18.3 18 3 cleft upper lip 0.00513984654926725 0.0410973397471492 1.49828302909814 0.545454545454545 18.3 18 3 increased circulating creatine kinase level 0.00513984654926725 0.0410973397471492 1.49828302909814 0.545454545454545 18.3 18 3 increased mammary gland tumor incidence 0.00513984654926725 0.0410973397471492 1.49828302909814 0.545454545454545 18.3 18 3 absent semicircular canals 0.0464169556694784 0.197023746467743 1.49828302909814 0.545454545454545 18.3 18 3 premature suture closure 0.0464169556694784 0.197023746467743 1.49828302909814 0.545454545454545 18.3 18 3 decreased atrioventricular cushion size 0.0464169556694784 0.197023746467743 1.49828302909814 0.545454545454545 18.3 18 3 abnormal awl hair morphology 0.0464169556694784 0.197023746467743 1.49828302909814 0.545454545454545 18.3 18 3 enlarged cranium 0.0464169556694784 0.197023746467743 1.49828302909814 0.545454545454545 18.3 18 3 abnormal eye distance/ position 0.0464169556694784 0.197023746467743 1.49828302909814 0.545454545454545 18.3 18 3 patent ductus arteriosus 0.0464169556694784 0.197023746467743 1.49828302909814 0.545454545454545 18.3 18 3 fused joints 0.0464169556694784 0.197023746467743 1.49828302909814 0.545454545454545 18.3 18 3 loss of cortex neurons 0.0464169556694784 0.197023746467743 1.49828302909814 0.545454545454545 18.3 18 3 pulmonary hypertension 0.0464169556694784 0.197023746467743 1.49828302909814 0.545454545454545 18.3 18 3 abnormal hair medulla 0.0464169556694784 0.197023746467743 1.49828302909814 0.545454545454545 18.3 18 3 abnormal crista ampullaris neuroepithelium morphology 0.0464169556694784 0.197023746467743 1.49828302909814 0.545454545454545 18.3 18 3 cyclopia 0.0464169556694784 0.197023746467743 1.49828302909814 0.545454545454545 18.3 18 3 abnormal Bruch membrane morphology 0.0464169556694784 0.197023746467743 1.49828302909814 0.545454545454545 18.3 18 3 aorta dilation 0.0464169556694784 0.197023746467743 1.49828302909814 0.545454545454545 18.3 18 3 decreased embryonic cilium length 0.0464169556694784 0.197023746467743 1.49828302909814 0.545454545454545 18.3 18 3 chylous ascites 0.0464169556694784 0.197023746467743 1.49828302909814 0.545454545454545 18.3 18 3 thin ventricular wall 2.27113051225872e-08 1.18935518931444e-06 1.4955084308961 0.544444444444444 18.3 18 3 decreased birth body size 3.48755863604831e-10 2.66932372528313e-08 1.49390208456861 0.543859649122807 18.3 18 3 pale yolk sac 9.91198102120079e-08 4.40286656968517e-06 1.48925722771803 0.542168674698795 18.3 18 3 lethality throughout fetal growth and development, complete penetrance 8.21966995511234e-16 1.63845662757134e-13 1.48908304558613 0.542105263157895 18.3 18 3 abnormal foregut morphology 0.00391418745967566 0.033925231031161 1.48787828584051 0.541666666666667 18.3 18 3 abnormal lung saccule morphology 0.00391418745967566 0.033925231031161 1.48787828584051 0.541666666666667 18.3 18 3 decreased double-positive T cell number 6.5510854657528e-09 3.92670484242412e-07 1.48330019880716 0.54 18.3 18 3 increased embryonic tissue cell apoptosis 3.36837889755013e-07 1.26952159206908e-05 1.47907427231483 0.538461538461538 18.3 18 3 ventricular hypoplasia 0.00298454462401206 0.0272943189420221 1.47907427231483 0.538461538461538 18.3 18 3 heart inflammation 0.00298454462401206 0.0272943189420221 1.47907427231483 0.538461538461538 18.3 18 3 decreased circulating glycerol level 0.00298454462401206 0.0272943189420221 1.47907427231483 0.538461538461538 18.3 18 3 absent teeth 0.0343315386183217 0.161588840705913 1.47907427231483 0.538461538461538 18.3 18 3 excessive scratching 0.0343315386183217 0.161588840705913 1.47907427231483 0.538461538461538 18.3 18 3 abnormal grip strength 0.0343315386183217 0.161588840705913 1.47907427231483 0.538461538461538 18.3 18 3 abnormal bile duct development 0.0343315386183217 0.161588840705913 1.47907427231483 0.538461538461538 18.3 18 3 abnormal telomere length 0.0343315386183217 0.161588840705913 1.47907427231483 0.538461538461538 18.3 18 3 abnormal exocrine pancreas morphology 0.0343315386183217 0.161588840705913 1.47907427231483 0.538461538461538 18.3 18 3 abnormal vertebral arch development 0.0343315386183217 0.161588840705913 1.47907427231483 0.538461538461538 18.3 18 3 increased renin activity 0.0343315386183217 0.161588840705913 1.47907427231483 0.538461538461538 18.3 18 3 orthokeratosis 0.0343315386183217 0.161588840705913 1.47907427231483 0.538461538461538 18.3 18 3 empty decidua capsularis 0.0343315386183217 0.161588840705913 1.47907427231483 0.538461538461538 18.3 18 3 abnormal aorta tunica media morphology 0.0343315386183217 0.161588840705913 1.47907427231483 0.538461538461538 18.3 18 3 extramedullary hematopoiesis 3.10159422991645e-09 1.97826042228645e-07 1.47708091076184 0.537735849056604 18.3 18 3 increased cell proliferation 2.31184221261557e-05 0.000500061522076629 1.47516137741453 0.537037037037037 18.3 18 3 abnormal apoptosis 2.31184221261557e-05 0.000500061522076629 1.47516137741453 0.537037037037037 18.3 18 3 abnormal embryo development 2.28330577385407e-11 2.2718892449848e-09 1.4744133239777 0.536764705882353 18.3 18 3 lethality at weaning, incomplete penetrance 0.000224441750140833 0.00331907857195539 1.47392070342175 0.536585365853659 18.3 18 3 shortened head 0.00227832885740543 0.0216310802778474 1.4715279750071 0.535714285714286 18.3 18 3 abnormal jaw morphology 0.00227832885740543 0.0216310802778474 1.4715279750071 0.535714285714286 18.3 18 3 premature aging 0.00227832885740543 0.0216310802778474 1.4715279750071 0.535714285714286 18.3 18 3 hypoxia 0.00227832885740543 0.0216310802778474 1.4715279750071 0.535714285714286 18.3 18 3 abnormal brainstem morphology 0.00227832885740543 0.0216310802778474 1.4715279750071 0.535714285714286 18.3 18 3 abnormal renal tubule epithelium morphology 0.00227832885740543 0.0216310802778474 1.4715279750071 0.535714285714286 18.3 18 3 subcutaneous edema 0.00227832885740543 0.0216310802778474 1.4715279750071 0.535714285714286 18.3 18 3 small placenta 0.00013334779104052 0.00218219909324865 1.46498785067374 0.533333333333333 18.3 18 3 delayed eyelid opening 0.00174106962010592 0.0176771864490346 1.46498785067374 0.533333333333333 18.3 18 3 enhanced paired-pulse facilitation 0.00174106962010592 0.0176771864490346 1.46498785067374 0.533333333333333 18.3 18 3 abnormal prostate gland morphology 0.0255495645116774 0.128393013581409 1.46498785067374 0.533333333333333 18.3 18 3 abnormal epidermis stratum spinosum morphology 0.0255495645116774 0.128393013581409 1.46498785067374 0.533333333333333 18.3 18 3 abnormal cricoid cartilage morphology 0.0255495645116774 0.128393013581409 1.46498785067374 0.533333333333333 18.3 18 3 abnormal bronchus morphology 0.0255495645116774 0.128393013581409 1.46498785067374 0.533333333333333 18.3 18 3 abnormal lymph node B cell domain morphology 0.0255495645116774 0.128393013581409 1.46498785067374 0.533333333333333 18.3 18 3 dilated ureter 0.0255495645116774 0.128393013581409 1.46498785067374 0.533333333333333 18.3 18 3 prenatal lethality 8.30600189946861e-06 0.000213001852834311 1.46203424613609 0.532258064516129 18.3 18 3 increased circulating follicle stimulating hormone level 0.00133180310223866 0.0142182841923548 1.45926524188204 0.53125 18.3 18 3 neonatal lethality 0.00133180310223866 0.0142182841923548 1.45926524188204 0.53125 18.3 18 3 increased fatty acid level 0.00133180310223866 0.0142182841923548 1.45926524188204 0.53125 18.3 18 3 increased neuron apoptosis 4.14388854590943e-07 1.53849593402234e-05 1.45820549951321 0.530864197530864 18.3 18 3 abnormal neural tube closure 3.21643482101525e-07 1.22150864385884e-05 1.45616262265763 0.530120481927711 18.3 18 3 cardiac fibrosis 2.49659378770698e-07 9.77996385341909e-06 1.45421588118349 0.529411764705882 18.3 18 3 decreased mean corpuscular hemoglobin 3.85805066647023e-06 0.000110309207274077 1.45421588118349 0.529411764705882 18.3 18 3 distended abdomen 6.12040335026481e-05 0.0011756373230721 1.45421588118349 0.529411764705882 18.3 18 3 hydroureter 0.0191069168148836 0.105854021329673 1.45421588118349 0.529411764705882 18.3 18 3 pancytopenia 0.0191069168148836 0.105854021329673 1.45421588118349 0.529411764705882 18.3 18 3 abnormal mesoderm development 4.72376271144727e-05 0.000955313800384153 1.45116721057304 0.528301886792453 18.3 18 3 increased circulating bilirubin level 4.72376271144727e-05 0.000955313800384153 1.45116721057304 0.528301886792453 18.3 18 3 abnormal head morphology 3.6467877042153e-05 0.000752811984583863 1.44834026146153 0.527272727272727 18.3 18 3 embryonic lethality during organogenesis, complete penetrance 1.81468975305915e-39 1.80561630429386e-36 1.44700250875698 0.526785714285714 18.3 18 3 kyphoscoliosis 0.0143455952578075 0.0873553689199417 1.44571169474382 0.526315789473684 18.3 18 3 small superior vagus ganglion 0.0143455952578075 0.0873553689199417 1.44571169474382 0.526315789473684 18.3 18 3 abnormal stationary movement 0.0143455952578075 0.0873553689199417 1.44571169474382 0.526315789473684 18.3 18 3 decreased tumor incidence 0.0143455952578075 0.0873553689199417 1.44571169474382 0.526315789473684 18.3 18 3 increased left ventricle weight 0.0143455952578075 0.0873553689199417 1.44571169474382 0.526315789473684 18.3 18 3 abnormal sternebra morphology 0.0143455952578075 0.0873553689199417 1.44571169474382 0.526315789473684 18.3 18 3 eyelids fail to open 0.0143455952578075 0.0873553689199417 1.44571169474382 0.526315789473684 18.3 18 3 thin interventricular septum 0.0143455952578075 0.0873553689199417 1.44571169474382 0.526315789473684 18.3 18 3 abnormal skin pigmentation 0.000459776269662292 0.00597228966467337 1.44209741550696 0.525 18.3 18 3 decreased hemoglobin content 6.86787795597608e-11 6.32735052425574e-09 1.44161038497149 0.524822695035461 18.3 18 3 abnormal embryonic tissue morphology 3.22962809113539e-11 3.08988456796126e-09 1.43882735334028 0.523809523809524 18.3 18 3 spleen hypoplasia 1.98421399897056e-08 1.06144781127726e-06 1.43882735334028 0.523809523809524 18.3 18 3 abnormal salivary gland morphology 0.0108062446499734 0.0709248906775959 1.43882735334028 0.523809523809524 18.3 18 3 left pulmonary isomerism 0.0108062446499734 0.0709248906775959 1.43882735334028 0.523809523809524 18.3 18 3 abnormal erythrocyte physiology 0.0108062446499734 0.0709248906775959 1.43882735334028 0.523809523809524 18.3 18 3 abnormal bile salt homeostasis 0.0108062446499734 0.0709248906775959 1.43882735334028 0.523809523809524 18.3 18 3 vascular ring 0.0108062446499734 0.0709248906775959 1.43882735334028 0.523809523809524 18.3 18 3 absent segment of posterior cerebral artery 0.0108062446499734 0.0709248906775959 1.43882735334028 0.523809523809524 18.3 18 3 abnormal cell death 0.000208550923771927 0.00316323428586993 1.43314028870257 0.521739130434783 18.3 18 3 abnormal myelin sheath morphology 0.000208550923771927 0.00316323428586993 1.43314028870257 0.521739130434783 18.3 18 3 atrial septal defect 0.000208550923771927 0.00316323428586993 1.43314028870257 0.521739130434783 18.3 18 3 abnormal cranial nerve morphology 0.00816275009623707 0.0572774072338215 1.43314028870257 0.521739130434783 18.3 18 3 abnormal nasal cavity morphology 0.00816275009623707 0.0572774072338215 1.43314028870257 0.521739130434783 18.3 18 3 abnormal cardiovascular development 0.00816275009623707 0.0572774072338215 1.43314028870257 0.521739130434783 18.3 18 3 abnormal Wolffian duct morphology 0.00816275009623707 0.0572774072338215 1.43314028870257 0.521739130434783 18.3 18 3 abnormal chondrocyte physiology 0.00816275009623707 0.0572774072338215 1.43314028870257 0.521739130434783 18.3 18 3 decreased effector memory CD8-positive, alpha-beta T cell number 0.00816275009623707 0.0572774072338215 1.43314028870257 0.521739130434783 18.3 18 3 abnormal vertebral artery topology 0.00816275009623707 0.0572774072338215 1.43314028870257 0.521739130434783 18.3 18 3 embryonic lethality during organogenesis, incomplete penetrance 1.78649431801236e-16 4.44390461605575e-14 1.43314028870257 0.521739130434783 18.3 18 3 thymus hypoplasia 1.75568024770887e-10 1.48042529361892e-08 1.43314028870257 0.521739130434783 18.3 18 3 decreased liver weight 4.63970666468232e-06 0.000129677194701093 1.43145819916184 0.52112676056338 18.3 18 3 abnormal fertility/fecundity 3.58883361277414e-06 0.000104411972067552 1.42986827891101 0.520547945205479 18.3 18 3 preweaning lethality, complete penetrance 1.72084356472369e-49 4.28059836725017e-46 1.42910554689879 0.52027027027027 18.3 18 3 short stride length 0.000123451822637156 0.00203368482655579 1.42836315440689 0.52 18.3 18 3 spontaneous skin ulceration 0.00618058883783426 0.0468012625087145 1.42836315440689 0.52 18.3 18 3 embryonic lethality before implantation, complete penetrance 1.58075881181908e-09 1.07729795736985e-07 1.42836315440689 0.52 18.3 18 3 delayed bone ossification 2.77645662746792e-06 8.22194745336482e-05 1.42836315440689 0.52 18.3 18 3 polyuria 2.14832536320028e-06 6.59748066785271e-05 1.4269362181887 0.519480519480519 18.3 18 3 abnormal placenta vasculature 9.50488362135067e-05 0.00168280412869109 1.42625019116073 0.519230769230769 18.3 18 3 abnormal brain commissure morphology 0.00468939067611936 0.0388828643561564 1.42429374371058 0.518518518518518 18.3 18 3 abnormal coat/hair pigmentation 1.42622047648658e-08 7.97241221406825e-07 1.42247704250686 0.517857142857143 18.3 18 3 abnormal eye development 5.64150615496918e-05 0.00110140489448724 1.42247704250686 0.517857142857143 18.3 18 3 increased insulin sensitivity 1.62466263538874e-10 1.4180169493086e-08 1.4214480019649 0.517482517482518 18.3 18 3 enlarged heart 4.19530204830754e-16 9.48710349560456e-14 1.42078563104134 0.517241379310345 18.3 18 3 abnormal retinal pigmentation 5.97197824523368e-07 2.12218512643125e-05 1.42078563104134 0.517241379310345 18.3 18 3 short sternum 0.00356438024052874 0.0311648360221977 1.42078563104134 0.517241379310345 18.3 18 3 epidermal hyperplasia 3.35354012473191e-05 0.000698069544792521 1.41920698034018 0.516666666666667 18.3 18 3 intracranial hemorrhage 3.35354012473191e-05 0.000698069544792521 1.41920698034018 0.516666666666667 18.3 18 3 osteopetrosis 0.00271356650439234 0.0249999877025035 1.41773017807136 0.516129032258065 18.3 18 3 abnormal capillary morphology 0.00271356650439234 0.0249999877025035 1.41773017807136 0.516129032258065 18.3 18 3 inner cell mass degeneration 0.00271356650439234 0.0249999877025035 1.41773017807136 0.516129032258065 18.3 18 3 decreased erythrocyte cell number 2.77069737705122e-11 2.70278812761369e-09 1.41716579503869 0.515923566878981 18.3 18 3 decreased birth weight 2.14954271884588e-07 8.62417340827278e-06 1.41679746084894 0.515789473684211 18.3 18 3 decreased circulating LDL cholesterol level 1.99616617257249e-05 0.000445333036257764 1.41634567594433 0.515625 18.3 18 3 decreased circulating serum albumin level 1.29047257750703e-07 5.58269658530213e-06 1.41504508303713 0.515151515151515 18.3 18 3 abnormal QRS complex 0.00206875445528156 0.0202201442338424 1.41504508303713 0.515151515151515 18.3 18 3 ovary cysts 0.00157915510022282 0.0162993705883995 1.41266685600682 0.514285714285714 18.3 18 3 decreased circulating thyroxine level 0.00157915510022282 0.0162993705883995 1.41266685600682 0.514285714285714 18.3 18 3 impaired adaptive thermogenesis 0.00157915510022282 0.0162993705883995 1.41266685600682 0.514285714285714 18.3 18 3 abnormal branching of the mammary ductal tree 0.00120679359105632 0.0130517350337069 1.4105457346014 0.513513513513513 18.3 18 3 increased erythroid progenitor cell number 0.00120679359105632 0.0130517350337069 1.4105457346014 0.513513513513513 18.3 18 3 preweaning lethality, incomplete penetrance 1.57159906156094e-26 7.8187053312657e-24 1.4103642205447 0.513447432762836 18.3 18 3 abnormal cornea morphology 3.27625519584482e-06 9.58786447019292e-05 1.40864216410936 0.512820512820513 18.3 18 3 small lens 0.000923180000149247 0.0103909966080147 1.40864216410936 0.512820512820513 18.3 18 3 increased hepatocyte apoptosis 0.000923180000149247 0.0103909966080147 1.40864216410936 0.512820512820513 18.3 18 3 oxidative stress 7.01873368475125e-07 2.44183217354108e-05 1.403946690229 0.511111111111111 18.3 18 3 prenatal lethality, complete penetrance 3.72948861948241e-18 1.15963786762031e-15 1.40306840015065 0.510791366906475 18.3 18 3 increased heart weight 7.98552412247357e-10 5.7576786245371e-08 1.40306840015065 0.510791366906475 18.3 18 3 thrombocytopenia 3.73141555002688e-10 2.81269581233087e-08 1.40184182262745 0.510344827586207 18.3 18 3 decreased urine osmolality 0.000244889682505803 0.00356235722358587 1.40145521429248 0.510204081632653 18.3 18 3 abnormal liver physiology 1.95224293659414e-07 7.96099066357035e-06 1.40089463220676 0.51 18.3 18 3 prenatal lethality, incomplete penetrance 1.39179041511297e-19 5.32627485783619e-17 1.40053320428307 0.509868421052632 18.3 18 3 postnatal growth retardation 5.03611664767491e-38 4.17578005369711e-35 1.40035603373225 0.509803921568627 18.3 18 3 microphthalmia 1.35371320228683e-10 1.2026291395316e-08 1.40035603373225 0.509803921568627 18.3 18 3 abnormal placenta development 0.000144698937970197 0.00232969972945544 1.39933981019543 0.509433962264151 18.3 18 3 abnormal joint morphology 0.000111317333289198 0.00185840178897236 1.39839749382493 0.509090909090909 18.3 18 3 decreased circulating total protein level 0.000111317333289198 0.00185840178897236 1.39839749382493 0.509090909090909 18.3 18 3 seminiferous tubule degeneration 1.07030971764385e-05 0.000262304967747691 1.39224016630809 0.506849315068493 18.3 18 3 decreased B cell proliferation 4.93132543186856e-06 0.000136296866401562 1.39081125063962 0.506329113924051 18.3 18 3 increased exploration in new environment 3.81060267659992e-06 0.00011021946695398 1.39038198790794 0.506172839506173 18.3 18 3 short limbs 1.76053788914658e-06 5.57877452134028e-05 1.3892126170182 0.505747126436782 18.3 18 3 abnormal definitive hematopoiesis 8.1479016373116e-07 2.75753813915818e-05 1.38819413269487 0.505376344086022 18.3 18 3 abnormal embryo size 6.30842139517725e-08 2.96818219379321e-06 1.38558032336952 0.504424778761062 18.3 18 3 perinatal lethality, complete penetrance 1.9419136912648e-13 2.84147665118894e-11 1.37987411991276 0.502347417840376 18.3 18 3 testicular atrophy 0.000366327542374448 0.00492432518923993 1.37342611000663 0.5 18.3 18 3 decreased oocyte number 0.000366327542374448 0.00492432518923993 1.37342611000663 0.5 18.3 18 3 abnormal neural tube morphology 2.08353022537808e-10 1.67186497923483e-08 1.37342611000663 0.5 18.3 18 3 decreased lymphocyte cell number 1.56791486496106e-08 8.47867005780575e-07 1.37342611000663 0.5 18.3 18 3 increased granulocyte number 1.59223114194458e-05 0.00036336467574194 1.37342611000663 0.5 18.3 18 3 abnormal tooth morphology 5.83751017660511e-05 0.00112564391971358 1.37342611000663 0.5 18.3 18 3 muscular ventricular septal defect 9.84145026153295e-05 0.00173007827035782 1.37342611000663 0.5 18.3 18 3 glomerulosclerosis 0.000127868865293295 0.00209949704565723 1.37342611000663 0.5 18.3 18 3 abnormal small intestine morphology 0.000216185720376963 0.00324931709630027 1.37342611000663 0.5 18.3 18 3 neurodegeneration 0.000216185720376963 0.00324931709630027 1.37342611000663 0.5 18.3 18 3 liver hypoplasia 0.000281330210460582 0.00402189022138331 1.37342611000663 0.5 18.3 18 3 decreased kidney weight 0.000281330210460582 0.00402189022138331 1.37342611000663 0.5 18.3 18 3 disheveled coat 0.00106069886394009 0.0117589474106411 1.37342611000663 0.5 18.3 18 3 bradykinesia 0.00409532990654598 0.0349949801724541 1.37342611000663 0.5 18.3 18 3 pancreatic islet hyperplasia 0.00409532990654598 0.0349949801724541 1.37342611000663 0.5 18.3 18 3 abnormal auditory brainstem response waveform shape 0.00409532990654598 0.0349949801724541 1.37342611000663 0.5 18.3 18 3 abnormal response to new environment 0.00538769086095156 0.0419464194573303 1.37342611000663 0.5 18.3 18 3 abnormal microglial cell physiology 0.00538769086095156 0.0419464194573303 1.37342611000663 0.5 18.3 18 3 abnormal cellular respiration 0.00538769086095156 0.0419464194573303 1.37342611000663 0.5 18.3 18 3 myoclonus 0.00710045249483329 0.0514938063583026 1.37342611000663 0.5 18.3 18 3 small superior cervical ganglion 0.00710045249483329 0.0514938063583026 1.37342611000663 0.5 18.3 18 3 abnormal somite shape 0.00710045249483329 0.0514938063583026 1.37342611000663 0.5 18.3 18 3 corneal vascularization 0.00710045249483329 0.0514938063583026 1.37342611000663 0.5 18.3 18 3 abnormal nasal bone morphology 0.00937663305165649 0.0633814530325965 1.37342611000663 0.5 18.3 18 3 abnormal erythrocyte osmotic lysis 0.00937663305165649 0.0633814530325965 1.37342611000663 0.5 18.3 18 3 abnormal Mullerian duct morphology 0.00937663305165649 0.0633814530325965 1.37342611000663 0.5 18.3 18 3 abnormal pericardium morphology 0.0219327312598312 0.111798502067275 1.37342611000663 0.5 18.3 18 3 abnormal cell proliferation 0.0219327312598312 0.111798502067275 1.37342611000663 0.5 18.3 18 3 small gonad 0.0219327312598312 0.111798502067275 1.37342611000663 0.5 18.3 18 3 abnormal circulating enzyme level 0.0219327312598312 0.111798502067275 1.37342611000663 0.5 18.3 18 3 increased urine glucose level 0.0219327312598312 0.111798502067275 1.37342611000663 0.5 18.3 18 3 abnormal hair texture 0.0219327312598312 0.111798502067275 1.37342611000663 0.5 18.3 18 3 abnormal hyoid bone morphology 0.0219327312598312 0.111798502067275 1.37342611000663 0.5 18.3 18 3 abnormal postnatal subventricular zone morphology 0.0219327312598312 0.111798502067275 1.37342611000663 0.5 18.3 18 3 abnormal response to tactile stimuli 0.0219327312598312 0.111798502067275 1.37342611000663 0.5 18.3 18 3 abnormal tympanic ring morphology 0.0393619885191939 0.176102421657365 1.37342611000663 0.5 18.3 18 3 white spotting 0.0393619885191939 0.176102421657365 1.37342611000663 0.5 18.3 18 3 abnormal molar crown morphology 0.0393619885191939 0.176102421657365 1.37342611000663 0.5 18.3 18 3 small pancreas 0.0393619885191939 0.176102421657365 1.37342611000663 0.5 18.3 18 3 sepsis 0.0393619885191939 0.176102421657365 1.37342611000663 0.5 18.3 18 3 decreased fibroblast apoptosis 0.0393619885191939 0.176102421657365 1.37342611000663 0.5 18.3 18 3 abnormal fluid regulation 0.0531603665113608 0.218934456452003 1.37342611000663 0.5 18.3 18 3 increased lactate dehydrogenase level 0.0531603665113608 0.218934456452003 1.37342611000663 0.5 18.3 18 3 abnormal ventral body wall morphology 0.0531603665113608 0.218934456452003 1.37342611000663 0.5 18.3 18 3 absent olfactory bulb 0.0531603665113608 0.218934456452003 1.37342611000663 0.5 18.3 18 3 abnormal vascular endothelial cell migration 0.0531603665113608 0.218934456452003 1.37342611000663 0.5 18.3 18 3 abnormal iris pigmentation 0.0531603665113608 0.218934456452003 1.37342611000663 0.5 18.3 18 3 abnormal glucose tolerance 0.0531603665113608 0.218934456452003 1.37342611000663 0.5 18.3 18 3 decreased cornea thickness 0.0531603665113608 0.218934456452003 1.37342611000663 0.5 18.3 18 3 pulmonary alveolar hemorrhage 0.0531603665113608 0.218934456452003 1.37342611000663 0.5 18.3 18 3 abnormal renal tubule epithelial cell primary cilium morphology 0.0531603665113608 0.218934456452003 1.37342611000663 0.5 18.3 18 3 multiple persisting craniopharyngeal ducts 0.0531603665113608 0.218934456452003 1.37342611000663 0.5 18.3 18 3 abnormal vitelline vein topology 0.0531603665113608 0.218934456452003 1.37342611000663 0.5 18.3 18 3 decreased response to antigen 0.0531603665113608 0.218934456452003 1.37342611000663 0.5 18.3 18 3 increased cranium width 0.09938849286885 0.314941243326452 1.37342611000663 0.5 18.3 18 3 abnormal prostate gland epithelium morphology 0.09938849286885 0.314941243326452 1.37342611000663 0.5 18.3 18 3 fused cornea and lens 0.09938849286885 0.314941243326452 1.37342611000663 0.5 18.3 18 3 absent trophoblast giant cells 0.09938849286885 0.314941243326452 1.37342611000663 0.5 18.3 18 3 abnormal primordial germ cell migration 0.09938849286885 0.314941243326452 1.37342611000663 0.5 18.3 18 3 impaired basement membrane formation 0.09938849286885 0.314941243326452 1.37342611000663 0.5 18.3 18 3 abnormal scala media morphology 0.09938849286885 0.314941243326452 1.37342611000663 0.5 18.3 18 3 intestinal edema 0.09938849286885 0.314941243326452 1.37342611000663 0.5 18.3 18 3 abnormal reproductive system development 0.09938849286885 0.314941243326452 1.37342611000663 0.5 18.3 18 3 abnormal plasma membrane morphology 0.09938849286885 0.314941243326452 1.37342611000663 0.5 18.3 18 3 abnormal deltoid tuberosity morphology 0.09938849286885 0.314941243326452 1.37342611000663 0.5 18.3 18 3 increased susceptibility to atherosclerosis 0.09938849286885 0.314941243326452 1.37342611000663 0.5 18.3 18 3 osteosclerosis 0.09938849286885 0.314941243326452 1.37342611000663 0.5 18.3 18 3 abnormal retinal blood vessel pattern 0.09938849286885 0.314941243326452 1.37342611000663 0.5 18.3 18 3 acanthocytosis 0.09938849286885 0.314941243326452 1.37342611000663 0.5 18.3 18 3 abnormal vibrissa follicle morphology 0.09938849286885 0.314941243326452 1.37342611000663 0.5 18.3 18 3 aorta stenosis 0.09938849286885 0.314941243326452 1.37342611000663 0.5 18.3 18 3 abnormal left subclavian artery morphology 0.09938849286885 0.314941243326452 1.37342611000663 0.5 18.3 18 3 thin ventricle myocardium compact layer 0.09938849286885 0.314941243326452 1.37342611000663 0.5 18.3 18 3 thick aortic valve cusps 0.09938849286885 0.314941243326452 1.37342611000663 0.5 18.3 18 3 decreased trabecular bone connectivity density 0.09938849286885 0.314941243326452 1.37342611000663 0.5 18.3 18 3 abnormal adaptive thermogenesis 0.09938849286885 0.314941243326452 1.37342611000663 0.5 18.3 18 3 sparse hair 5.66224931411398e-06 0.000154778518339105 1.37342611000663 0.5 18.3 18 3 abnormal neuromuscular synapse morphology 2.06330059883148e-05 0.000453350527200269 1.37342611000663 0.5 18.3 18 3 hydrops fetalis 2.06330059883148e-05 0.000453350527200269 1.37342611000663 0.5 18.3 18 3 pericardial edema 3.4680831119194e-05 0.000718904728408292 1.37342611000663 0.5 18.3 18 3 pericardial effusion 7.57793704032487e-05 0.0014014957909151 1.37342611000663 0.5 18.3 18 3 thymus atrophy 0.000477318293657428 0.00615196505426348 1.37342611000663 0.5 18.3 18 3 hypertension 0.000812157767841581 0.0093964765000276 1.37342611000663 0.5 18.3 18 3 abnormal epidermis stratum granulosum morphology 0.002376991899833 0.0224820051362531 1.37342611000663 0.5 18.3 18 3 abnormal retinal photoreceptor morphology 0.0031178517076172 0.02804938923218 1.37342611000663 0.5 18.3 18 3 abnormal oocyte morphology 0.0031178517076172 0.02804938923218 1.37342611000663 0.5 18.3 18 3 abnormal endoderm development 0.0031178517076172 0.02804938923218 1.37342611000663 0.5 18.3 18 3 impaired synaptic plasticity 0.0031178517076172 0.02804938923218 1.37342611000663 0.5 18.3 18 3 abnormal brown adipose tissue morphology 0.0031178517076172 0.02804938923218 1.37342611000663 0.5 18.3 18 3 ocular hypertelorism 0.0124113127327985 0.0786576826059524 1.37342611000663 0.5 18.3 18 3 abnormal retinal ganglion layer morphology 0.0124113127327985 0.0786576826059524 1.37342611000663 0.5 18.3 18 3 abnormal inner cell mass apoptosis 0.0124113127327985 0.0786576826059524 1.37342611000663 0.5 18.3 18 3 intestinal inflammation 0.0164726427506795 0.0976774704226826 1.37342611000663 0.5 18.3 18 3 increased skin papilloma incidence 0.0164726427506795 0.0976774704226826 1.37342611000663 0.5 18.3 18 3 abnormal tracheal cartilage morphology 0.0164726427506795 0.0976774704226826 1.37342611000663 0.5 18.3 18 3 parakeratosis 0.0164726427506795 0.0976774704226826 1.37342611000663 0.5 18.3 18 3 prolonged PR interval 0.0164726427506795 0.0976774704226826 1.37342611000663 0.5 18.3 18 3 abnormal mammary gland morphology 0.0293141353729403 0.1400939706824 1.37342611000663 0.5 18.3 18 3 abnormal thymus cortex morphology 0.0293141353729403 0.1400939706824 1.37342611000663 0.5 18.3 18 3 abnormal Peyer's patch follicle morphology 0.0293141353729403 0.1400939706824 1.37342611000663 0.5 18.3 18 3 abnormal bile duct morphology 0.0293141353729403 0.1400939706824 1.37342611000663 0.5 18.3 18 3 abnormal redox activity 0.0293141353729403 0.1400939706824 1.37342611000663 0.5 18.3 18 3 increased circulating renin level 0.0293141353729403 0.1400939706824 1.37342611000663 0.5 18.3 18 3 abnormal body wall morphology 0.0293141353729403 0.1400939706824 1.37342611000663 0.5 18.3 18 3 abnormal neutrophil morphology 0.0293141353729403 0.1400939706824 1.37342611000663 0.5 18.3 18 3 abnormal anterior eye segment morphology 0.0293141353729403 0.1400939706824 1.37342611000663 0.5 18.3 18 3 decreased pulmonary respiratory rate 0.0293141353729403 0.1400939706824 1.37342611000663 0.5 18.3 18 3 increased gastrointestinal tumor incidence 0.0293141353729403 0.1400939706824 1.37342611000663 0.5 18.3 18 3 increased adipocyte glucose uptake 0.0293141353729403 0.1400939706824 1.37342611000663 0.5 18.3 18 3 mesocardia 0.0723299970856918 0.248853205740883 1.37342611000663 0.5 18.3 18 3 abnormal superior cervical ganglion morphology 0.0723299970856918 0.248853205740883 1.37342611000663 0.5 18.3 18 3 abnormal glossopharyngeal nerve morphology 0.0723299970856918 0.248853205740883 1.37342611000663 0.5 18.3 18 3 abnormal mating frequency 0.0723299970856918 0.248853205740883 1.37342611000663 0.5 18.3 18 3 abnormal thymus involution 0.0723299970856918 0.248853205740883 1.37342611000663 0.5 18.3 18 3 myocarditis 0.0723299970856918 0.248853205740883 1.37342611000663 0.5 18.3 18 3 absent ovary 0.0723299970856918 0.248853205740883 1.37342611000663 0.5 18.3 18 3 delayed somite formation 0.0723299970856918 0.248853205740883 1.37342611000663 0.5 18.3 18 3 decreased left ventricle systolic pressure 0.0723299970856918 0.248853205740883 1.37342611000663 0.5 18.3 18 3 bowed ulna 0.0723299970856918 0.248853205740883 1.37342611000663 0.5 18.3 18 3 small parietal bone 0.0723299970856918 0.248853205740883 1.37342611000663 0.5 18.3 18 3 abnormal cochlear outer hair cell physiology 0.0723299970856918 0.248853205740883 1.37342611000663 0.5 18.3 18 3 abnormal thymus corticomedullary boundary morphology 0.0723299970856918 0.248853205740883 1.37342611000663 0.5 18.3 18 3 decreased keratinocyte proliferation 0.0723299970856918 0.248853205740883 1.37342611000663 0.5 18.3 18 3 impaired behavioral response to cocaine 0.0723299970856918 0.248853205740883 1.37342611000663 0.5 18.3 18 3 embryonic lethality between implantation and placentation, incomplete penetrance 0.0723299970856918 0.248853205740883 1.37342611000663 0.5 18.3 18 3 abnormal colon goblet cell morphology 0.0723299970856918 0.248853205740883 1.37342611000663 0.5 18.3 18 3 anemia 6.99368156742341e-13 9.66487938831429e-11 1.36691698152318 0.497630331753554 18.3 18 3 abnormal blood vessel morphology 3.00896048202488e-09 1.9696813681676e-07 1.36395420579968 0.496551724137931 18.3 18 3 cataract 6.38382903991706e-08 2.96818219379321e-06 1.36207548099831 0.495867768595041 18.3 18 3 abnormal bone mineralization 6.38382903991706e-08 2.96818219379321e-06 1.36207548099831 0.495867768595041 18.3 18 3 perinatal lethality, incomplete penetrance 1.73982507768364e-13 2.6715304875297e-11 1.36127189664374 0.495575221238938 18.3 18 3 abnormal hepatocyte morphology 2.28809585091952e-07 9.1066214866597e-06 1.36105290180837 0.495495495495495 18.3 18 3 infertility 3.81574088158026e-07 1.42731660795953e-05 1.36059035196918 0.495327102803738 18.3 18 3 increased mean corpuscular hemoglobin 1.0628960412653e-06 3.44481570989533e-05 1.35955311899646 0.494949494949495 18.3 18 3 small spleen 2.96823981594848e-06 8.73786573038087e-05 1.35833351539117 0.494505494505495 18.3 18 3 decreased rib number 3.83882821622914e-06 0.000110309207274077 1.35799435596161 0.49438202247191 18.3 18 3 decreased total body fat amount 5.51102689822341e-19 1.8278239212441e-16 1.35697789312032 0.494011976047904 18.3 18 3 abnormal placenta labyrinth morphology 1.39348386693219e-05 0.000325473344506463 1.35604096937363 0.493670886075949 18.3 18 3 abnormal nervous system morphology 1.39348386693219e-05 0.000325473344506463 1.35604096937363 0.493670886075949 18.3 18 3 kyphosis 2.64208527287004e-09 1.75258323100379e-07 1.35511376187321 0.493333333333333 18.3 18 3 decreased bone marrow cell number 3.02945388863563e-05 0.000641341833870734 1.35461205370517 0.493150684931507 18.3 18 3 abnormal sternum morphology 5.09175317450199e-05 0.00101732819450391 1.35352138377465 0.492753623188406 18.3 18 3 ventricular septal defect 1.56511700701155e-08 8.47867005780575e-07 1.35322866721241 0.492647058823529 18.3 18 3 abnormal lipid homeostasis 3.35799952109049e-08 1.68049157795822e-06 1.35229647754499 0.492307692307692 18.3 18 3 abnormal hair follicle morphology 0.000111246265665068 0.00185840178897236 1.35162569556208 0.492063492063492 18.3 18 3 respiratory distress 2.35588241947691e-10 1.86039921220597e-08 1.34960947226085 0.491329479768786 18.3 18 3 absent kidney 0.000700449760362992 0.00821872065520256 1.34539700572078 0.489795918367347 18.3 18 3 decreased body length 2.95360200854858e-15 5.44228518241821e-13 1.34335108569991 0.489051094890511 18.3 18 3 cardiomyopathy 0.00119160234409355 0.0129437154189201 1.34290552978426 0.488888888888889 18.3 18 3 cleft palate 4.86020091787414e-08 2.32495188138691e-06 1.3419736036706 0.488549618320611 18.3 18 3 decreased oxygen consumption 0.00155609261179403 0.0161619222206165 1.34148596791345 0.488372093023256 18.3 18 3 hydronephrosis 1.20706424289574e-05 0.000290103604270836 1.3407254883398 0.488095238095238 18.3 18 3 increased bone mineral content 8.01456013464028e-07 2.73098881300243e-05 1.33562539138259 0.486238532110092 18.3 18 3 abnormal digit morphology 5.68966950519035e-05 0.00110140489448724 1.33527538472866 0.486111111111111 18.3 18 3 abnormal forebrain development 5.68966950519035e-05 0.00110140489448724 1.33527538472866 0.486111111111111 18.3 18 3 abnormal retina morphology 9.55630390200503e-12 9.90471081509896e-10 1.33418536400644 0.485714285714286 18.3 18 3 decreased triglyceride level 0.00457106517015635 0.0379650237421166 1.33418536400644 0.485714285714286 18.3 18 3 abnormal heart morphology 1.0965543085943e-12 1.36383942131416e-10 1.33180713697612 0.484848484848485 18.3 18 3 decreased brown adipose tissue amount 0.00600269503714785 0.0457587729963137 1.33180713697612 0.484848484848485 18.3 18 3 abnormal locomotor coordination 0.00600269503714785 0.0457587729963137 1.33180713697612 0.484848484848485 18.3 18 3 abnormal cranial ganglia morphology 0.00789468244522588 0.0564973694237004 1.3291220419419 0.483870967741935 18.3 18 3 abnormal postnatal growth/weight/body size 0.00789468244522588 0.0564973694237004 1.3291220419419 0.483870967741935 18.3 18 3 abnormal retinal photoreceptor layer morphology 0.00789468244522588 0.0564973694237004 1.3291220419419 0.483870967741935 18.3 18 3 abnormal incisor morphology 0.000271224461830563 0.00389983149597414 1.32764523967307 0.483333333333333 18.3 18 3 increased blood urea nitrogen level 2.17846998739107e-08 1.15296682843304e-06 1.32606658897192 0.482758620689655 18.3 18 3 abnormal embryonic neuroepithelium morphology 0.000352356932460656 0.00481586741481253 1.32606658897192 0.482758620689655 18.3 18 3 focal hair loss 0.0104007865988508 0.0695482706038747 1.32606658897192 0.482758620689655 18.3 18 3 increased circulating alkaline phosphatase level 4.09881755347948e-09 2.54895216607005e-07 1.32255847630268 0.481481481481481 18.3 18 3 diluted coat color 0.000595565314448941 0.00733400356283039 1.32255847630268 0.481481481481481 18.3 18 3 abnormal long bone epiphyseal plate proliferative zone 0.000595565314448941 0.00733400356283039 1.32255847630268 0.481481481481481 18.3 18 3 axon degeneration 0.000595565314448941 0.00733400356283039 1.32255847630268 0.481481481481481 18.3 18 3 abnormal heart valve morphology 0.0137290724003695 0.0859146354614318 1.32255847630268 0.481481481481481 18.3 18 3 abnormal eye muscle morphology 0.0137290724003695 0.0859146354614318 1.32255847630268 0.481481481481481 18.3 18 3 abnormal palate morphology 0.0137290724003695 0.0859146354614318 1.32255847630268 0.481481481481481 18.3 18 3 hemorrhage 1.73015414974852e-12 2.04940878452354e-10 1.32082681217659 0.480851063829787 18.3 18 3 ataxia 6.85196742718708e-11 6.32735052425574e-09 1.31903299673904 0.48019801980198 18.3 18 3 abnormal interventricular septum morphology 0.00100887026927548 0.0113043459226251 1.31848906560636 0.48 18.3 18 3 mandible hypoplasia 0.018162750174304 0.104221086640325 1.31848906560636 0.48 18.3 18 3 abnormal kidney morphology 1.27960803918143e-09 8.96626759848962e-08 1.31848906560636 0.48 18.3 18 3 spleen hyperplasia 6.28626858354658e-05 0.00118913255525263 1.31848906560636 0.48 18.3 18 3 decreased percent body fat/body weight 8.13986809938549e-05 0.00147795050344682 1.31698394110225 0.479452054794521 18.3 18 3 abnormal ovary morphology 0.000105428917686887 0.00181325348800643 1.31539402085142 0.47887323943662 18.3 18 3 increased circulating free fatty acid level 0.000105428917686887 0.00181325348800643 1.31539402085142 0.47887323943662 18.3 18 3 reduced female fertility 4.05236226151541e-12 4.48011161134204e-10 1.31422670871324 0.478448275862069 18.3 18 3 conjunctivitis 0.024090044350585 0.121796718134309 1.31371193131069 0.478260869565217 18.3 18 3 abnormal sacral vertebrae morphology 0.024090044350585 0.121796718134309 1.31371193131069 0.478260869565217 18.3 18 3 abnormal lens development 0.024090044350585 0.121796718134309 1.31371193131069 0.478260869565217 18.3 18 3 decreased insulin secretion 1.47487986287606e-05 0.000339700338787426 1.31238494956189 0.477777777777778 18.3 18 3 renal interstitial fibrosis 0.00223533746931584 0.0215102590132423 1.31099765046087 0.477272727272727 18.3 18 3 embryonic lethality, incomplete penetrance 0.00223533746931584 0.0215102590132423 1.31099765046087 0.477272727272727 18.3 18 3 abnormal renal glomerulus morphology 2.0983528546278e-06 6.48404065327533e-05 1.3104249122999 0.477064220183486 18.3 18 3 respiratory failure 2.64077984436634e-08 1.3685291380961e-06 1.30975734994009 0.47682119205298 18.3 18 3 premature death 2.04951231784479e-40 2.54908094531946e-37 1.30802486667298 0.476190476190476 18.3 18 3 spina bifida 0.00291867218304428 0.0268399151767935 1.30802486667298 0.476190476190476 18.3 18 3 increased keratinocyte proliferation 0.0320477190869748 0.152864240132023 1.30802486667298 0.476190476190476 18.3 18 3 gliosis 0.000297612537775538 0.00418026310623399 1.30802486667298 0.476190476190476 18.3 18 3 syndactyly 0.000501079640816212 0.00641833142154466 1.30359088407409 0.474576271186441 18.3 18 3 increased rib number 6.87607796571093e-05 0.00128603337892526 1.30299400180116 0.474358974358974 18.3 18 3 abnormal frontal bone morphology 0.00498964587631397 0.0410910681762274 1.30114052526944 0.473684210526316 18.3 18 3 decreased total retina thickness 0.00498964587631397 0.0410910681762274 1.30114052526944 0.473684210526316 18.3 18 3 shiny skin 0.0427858214765598 0.189376745414489 1.30114052526944 0.473684210526316 18.3 18 3 short vibrissae 0.0427858214765598 0.189376745414489 1.30114052526944 0.473684210526316 18.3 18 3 unresponsive to tactile stimuli 0.0427858214765598 0.189376745414489 1.30114052526944 0.473684210526316 18.3 18 3 abnormal metatarsal bone morphology 0.0427858214765598 0.189376745414489 1.30114052526944 0.473684210526316 18.3 18 3 abnormal optic vesicle formation 0.0427858214765598 0.189376745414489 1.30114052526944 0.473684210526316 18.3 18 3 abnormal photoreceptor inner segment morphology 0.0427858214765598 0.189376745414489 1.30114052526944 0.473684210526316 18.3 18 3 Leydig cell hypoplasia 0.0427858214765598 0.189376745414489 1.30114052526944 0.473684210526316 18.3 18 3 increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 0.0427858214765598 0.189376745414489 1.30114052526944 0.473684210526316 18.3 18 3 shortened RR interval 0.0427858214765598 0.189376745414489 1.30114052526944 0.473684210526316 18.3 18 3 decreased brain weight 0.000650573280497476 0.0077802934386417 1.30114052526944 0.473684210526316 18.3 18 3 decreased circulating glucose level 1.14570840444631e-13 1.89996643737346e-11 1.29958599656541 0.473118279569892 18.3 18 3 neonatal lethality, incomplete penetrance 7.79323071825862e-13 1.02029796903517e-10 1.29947239639089 0.473076923076923 18.3 18 3 small seminiferous tubules 0.000115042069924129 0.0019141615313463 1.29918686081708 0.472972972972973 18.3 18 3 abnormal rostral-caudal axis patterning 0.000845036665124788 0.00962026867047099 1.29851195855172 0.472727272727273 18.3 18 3 decreased hematocrit 7.89995180941419e-08 3.57293275016687e-06 1.29816988480078 0.472602739726027 18.3 18 3 abnormal B cell differentiation 2.07766673772184e-05 0.000453350527200269 1.29796313692934 0.472527472527473 18.3 18 3 increased grip strength 2.07766673772184e-05 0.000453350527200269 1.29796313692934 0.472527472527473 18.3 18 3 abnormal lysosome morphology 0.00653418335939299 0.0485187495716121 1.2971246594507 0.472222222222222 18.3 18 3 abnormal bone structure 8.60707110782294e-10 6.11716839448845e-08 1.29514793793371 0.471502590673575 18.3 18 3 edema 7.56055602760734e-09 4.42514896909959e-07 1.29357575477368 0.47093023255814 18.3 18 3 abnormal response to novel object 0.0014277646427282 0.0148912559697542 1.29263633882977 0.470588235294118 18.3 18 3 abnormal direction of heart looping 0.00856700021895281 0.0596930337385017 1.29263633882977 0.470588235294118 18.3 18 3 abnormal vagus nerve morphology 0.057366496700803 0.234317176589897 1.29263633882977 0.470588235294118 18.3 18 3 nephrocalcinosis 0.057366496700803 0.234317176589897 1.29263633882977 0.470588235294118 18.3 18 3 increased regulatory T cell number 0.057366496700803 0.234317176589897 1.29263633882977 0.470588235294118 18.3 18 3 abnormal tarsal bone morphology 0.057366496700803 0.234317176589897 1.29263633882977 0.470588235294118 18.3 18 3 coloboma 0.057366496700803 0.234317176589897 1.29263633882977 0.470588235294118 18.3 18 3 delayed heart development 0.057366496700803 0.234317176589897 1.29263633882977 0.470588235294118 18.3 18 3 abnormal ductus venosus valve morphology 0.057366496700803 0.234317176589897 1.29263633882977 0.470588235294118 18.3 18 3 decreased body fat mass 0.057366496700803 0.234317176589897 1.29263633882977 0.470588235294118 18.3 18 3 cardiac hypertrophy 1.35289316206209e-05 0.000320902851918606 1.28933879714908 0.469387755102041 18.3 18 3 abnormal osteoclast physiology 0.00041822967410645 0.00548995416538149 1.28758697813121 0.46875 18.3 18 3 scoliosis 0.0112470523322963 0.0726676433158106 1.28758697813121 0.46875 18.3 18 3 abnormal embryonic hematopoiesis 0.0112470523322963 0.0726676433158106 1.28758697813121 0.46875 18.3 18 3 abnormal visceral yolk sac morphology 9.62816188090484e-05 0.0016985852963653 1.28650040684165 0.468354430379747 18.3 18 3 neuron degeneration 0.00241751367096475 0.0228218795314034 1.28576061362323 0.468085106382979 18.3 18 3 decreased body size 1.06244439556749e-34 6.60707608493531e-32 1.28392967176058 0.467418546365915 18.3 18 3 abnormal glucose homeostasis 5.36083666417928e-09 3.29261264250518e-07 1.28287054231388 0.467032967032967 18.3 18 3 decreased body weight 2.641749193094e-53 1.31427022356427e-49 1.28245604456192 0.466882067851373 18.3 18 3 increased erythrocyte cell number 0.000702202922428654 0.00821990479784131 1.28186436933952 0.466666666666667 18.3 18 3 abnormal heart tube morphology 0.0147872453695127 0.0897152996503973 1.28186436933952 0.466666666666667 18.3 18 3 abnormal fat pad morphology 0.0147872453695127 0.0897152996503973 1.28186436933952 0.466666666666667 18.3 18 3 macrocytosis 0.0773198182610837 0.261677616223736 1.28186436933952 0.466666666666667 18.3 18 3 interdigital webbing 0.0773198182610837 0.261677616223736 1.28186436933952 0.466666666666667 18.3 18 3 vagina atresia 0.0773198182610837 0.261677616223736 1.28186436933952 0.466666666666667 18.3 18 3 hyperpigmentation 0.0773198182610837 0.261677616223736 1.28186436933952 0.466666666666667 18.3 18 3 abnormal apical ectodermal ridge morphology 0.0773198182610837 0.261677616223736 1.28186436933952 0.466666666666667 18.3 18 3 placental labyrinth hypoplasia 0.0773198182610837 0.261677616223736 1.28186436933952 0.466666666666667 18.3 18 3 arthritis 0.0773198182610837 0.261677616223736 1.28186436933952 0.466666666666667 18.3 18 3 abnormal glial cell morphology 0.0773198182610837 0.261677616223736 1.28186436933952 0.466666666666667 18.3 18 3 abnormal pericyte morphology 0.0773198182610837 0.261677616223736 1.28186436933952 0.466666666666667 18.3 18 3 abnormal ear development 0.0773198182610837 0.261677616223736 1.28186436933952 0.466666666666667 18.3 18 3 abnormal energy homeostasis 0.0773198182610837 0.261677616223736 1.28186436933952 0.466666666666667 18.3 18 3 abnormal secondary palate development 0.0773198182610837 0.261677616223736 1.28186436933952 0.466666666666667 18.3 18 3 abnormal aorta wall morphology 0.0773198182610837 0.261677616223736 1.28186436933952 0.466666666666667 18.3 18 3 liver vascular congestion 0.0773198182610837 0.261677616223736 1.28186436933952 0.466666666666667 18.3 18 3 herniated liver 0.0773198182610837 0.261677616223736 1.28186436933952 0.466666666666667 18.3 18 3 decreased brown adipose tissue mass 0.0773198182610837 0.261677616223736 1.28186436933952 0.466666666666667 18.3 18 3 decreased bone mineral density 2.26324018636623e-12 2.55900452890273e-10 1.28048750105881 0.466165413533835 18.3 18 3 increased oxygen consumption 6.21591134716978e-05 0.00118031141038816 1.27760568372709 0.465116279069767 18.3 18 3 abnormal blood homeostasis 4.43418846355105e-06 0.000125341406853218 1.27704533035704 0.464912280701754 18.3 18 3 short mandible 0.00118048745121003 0.0128510395399779 1.27532424500615 0.464285714285714 18.3 18 3 failure of blastocyst to hatch from the zona pellucida 0.019473876318501 0.106121694826177 1.27532424500615 0.464285714285714 18.3 18 3 abnormal retinal inner nuclear layer morphology 0.019473876318501 0.106121694826177 1.27532424500615 0.464285714285714 18.3 18 3 increased triglyceride level 0.019473876318501 0.106121694826177 1.27532424500615 0.464285714285714 18.3 18 3 prolonged QRS complex duration 0.019473876318501 0.106121694826177 1.27532424500615 0.464285714285714 18.3 18 3 small testis 1.59048715903802e-12 1.92992039419858e-10 1.27390247884673 0.463768115942029 18.3 18 3 scaly skin 0.00535190385000614 0.0418643422229254 1.27293151659151 0.463414634146341 18.3 18 3 thick ventricular wall 0.00535190385000614 0.0418643422229254 1.27293151659151 0.463414634146341 18.3 18 3 liver fibrosis 0.00535190385000614 0.0418643422229254 1.27293151659151 0.463414634146341 18.3 18 3 alopecia 3.11213539292885e-05 0.000656053965246654 1.27222629137456 0.463157894736842 18.3 18 3 abnormal heart development 1.06742433005855e-07 4.65827722986076e-06 1.26911526620866 0.462025316455696 18.3 18 3 limb grasping 1.30329228503091e-08 7.36804445230541e-07 1.26777794769843 0.461538461538462 18.3 18 3 abnormal heart ventricle morphology 0.000172050901850117 0.00270871277438079 1.26777794769842 0.461538461538462 18.3 18 3 distended pericardium 0.00198735091129437 0.0197346722229331 1.26777794769842 0.461538461538462 18.3 18 3 abnormal xiphoid process morphology 0.0256937077080019 0.128468538540009 1.26777794769842 0.461538461538462 18.3 18 3 abnormal leukocyte cell number 0.0256937077080019 0.128468538540009 1.26777794769842 0.461538461538462 18.3 18 3 thick skin 0.0256937077080019 0.128468538540009 1.26777794769842 0.461538461538462 18.3 18 3 decreased bone resorption 0.0256937077080019 0.128468538540009 1.26777794769842 0.461538461538462 18.3 18 3 short hair 0.104900104343438 0.328431730087226 1.26777794769842 0.461538461538462 18.3 18 3 small trigeminal ganglion 0.104900104343438 0.328431730087226 1.26777794769842 0.461538461538462 18.3 18 3 uterus hypoplasia 0.104900104343438 0.328431730087226 1.26777794769842 0.461538461538462 18.3 18 3 abnormal pulmonary alveolus epithelial cell morphology 0.104900104343438 0.328431730087226 1.26777794769842 0.461538461538462 18.3 18 3 dystrophic cardiac calcinosis 0.104900104343438 0.328431730087226 1.26777794769842 0.461538461538462 18.3 18 3 absent lateral semicircular canal 0.104900104343438 0.328431730087226 1.26777794769842 0.461538461538462 18.3 18 3 tracheoesophageal fistula 0.104900104343438 0.328431730087226 1.26777794769842 0.461538461538462 18.3 18 3 muscle fatigue 0.104900104343438 0.328431730087226 1.26777794769842 0.461538461538462 18.3 18 3 small otic vesicle 0.104900104343438 0.328431730087226 1.26777794769842 0.461538461538462 18.3 18 3 small interparietal bone 0.104900104343438 0.328431730087226 1.26777794769842 0.461538461538462 18.3 18 3 increased cochlear inner hair cell number 0.104900104343438 0.328431730087226 1.26777794769842 0.461538461538462 18.3 18 3 decreased cardiac stroke volume 0.104900104343438 0.328431730087226 1.26777794769842 0.461538461538462 18.3 18 3 abnormal lens morphology 1.86307036552164e-06 5.7944281902669e-05 1.26612719516236 0.4609375 18.3 18 3 impaired balance 2.00725563548739e-05 0.000445807892256685 1.26570641510415 0.46078431372549 18.3 18 3 decreased susceptibility to hepatic steatosis 0.000750157341465397 0.00874012359201487 1.26442403778388 0.46031746031746 18.3 18 3 increased circulating aspartate transaminase level 0.000750157341465397 0.00874012359201487 1.26442403778388 0.46031746031746 18.3 18 3 increased spleen weight 7.83795129449233e-06 0.000202040454352846 1.26403818974061 0.460176991150442 18.3 18 3 abnormal hindlimb morphology 0.00258008364612603 0.0240409507193651 1.2635520212061 0.46 18.3 18 3 abnormal axon extension 0.00258008364612603 0.0240409507193651 1.2635520212061 0.46 18.3 18 3 abnormal intestine morphology 0.000286382217648754 0.00405476378538775 1.26206723622231 0.459459459459459 18.3 18 3 malocclusion 0.00912547851453044 0.0620208409969794 1.26206723622231 0.459459459459459 18.3 18 3 abnormal urine homeostasis 4.26974006969617e-05 0.000877766811848697 1.25897393417274 0.458333333333333 18.3 18 3 abnormal cardiovascular system morphology 0.00335100030886832 0.0299842203896041 1.25897393417274 0.458333333333333 18.3 18 3 abnormal kidney physiology 0.00335100030886832 0.0299842203896041 1.25897393417274 0.458333333333333 18.3 18 3 curly vibrissae 0.0339720480271737 0.161578335502093 1.25897393417274 0.458333333333333 18.3 18 3 abnormal nursing 0.0339720480271737 0.161578335502093 1.25897393417274 0.458333333333333 18.3 18 3 postnatal lethality 9.46382380992048e-08 4.24166877967156e-06 1.25759499229522 0.457831325301205 18.3 18 3 abnormal colon morphology 0.00125559829948523 0.0135207825539806 1.25703406678573 0.457627118644068 18.3 18 3 cleft secondary palate 5.49092581602437e-05 0.00108402206090164 1.25653878149542 0.457446808510638 18.3 18 3 thick epidermis 0.000476848689302447 0.00615196505426348 1.25570387200606 0.457142857142857 18.3 18 3 increased red blood cell distribution width 0.0119319981547814 0.075910090562708 1.25570387200606 0.457142857142857 18.3 18 3 decreased heart weight 0.000182843156695531 0.00285155079799456 1.25473496469741 0.45679012345679 18.3 18 3 postnatal lethality, complete penetrance 8.77297272977189e-16 1.67867458963905e-13 1.25245075316666 0.455958549222798 18.3 18 3 decreased circulating alanine transaminase level 0.000615392541699445 0.00748552052556171 1.25224145324134 0.455882352941176 18.3 18 3 abnormal myocardium layer morphology 0.000235485650442638 0.00343560443094465 1.25173012557566 0.455696202531646 18.3 18 3 increased circulating triglyceride level 8.26996284451204e-07 2.77993683455726e-05 1.25029135531638 0.455172413793103 18.3 18 3 enlarged spleen 4.86792298094415e-12 5.26476452830373e-10 1.24943625285325 0.454861111111111 18.3 18 3 decreased circulating calcium level 0.0021033579270498 0.0205180503668093 1.24856919091512 0.454545454545455 18.3 18 3 small kidney 0.00011675805015539 0.00193623766507689 1.24856919091512 0.454545454545455 18.3 18 3 abnormal skin morphology 0.000794254130446519 0.00921075594165835 1.24856919091512 0.454545454545455 18.3 18 3 increased body size 0.0450269493672209 0.197023746467743 1.24856919091512 0.454545454545455 18.3 18 3 abnormal tail movements 0.0450269493672209 0.197023746467743 1.24856919091512 0.454545454545455 18.3 18 3 intracerebral hemorrhage 0.0450269493672209 0.197023746467743 1.24856919091512 0.454545454545455 18.3 18 3 abnormal lysosome physiology 0.0450269493672209 0.197023746467743 1.24856919091512 0.454545454545455 18.3 18 3 abnormal cochlear sensory epithelium morphology 0.0450269493672209 0.197023746467743 1.24856919091512 0.454545454545455 18.3 18 3 decreased cardiac output 0.0450269493672209 0.197023746467743 1.24856919091512 0.454545454545455 18.3 18 3 abnormal circulating lipid level 0.0450269493672209 0.197023746467743 1.24856919091512 0.454545454545455 18.3 18 3 abnormal mesenteric lymph node morphology 0.0450269493672209 0.197023746467743 1.24856919091512 0.454545454545455 18.3 18 3 abnormal occipital bone morphology 0.0450269493672209 0.197023746467743 1.24856919091512 0.454545454545455 18.3 18 3 rough coat 0.0450269493672209 0.197023746467743 1.24856919091512 0.454545454545455 18.3 18 3 abnormal food preference 0.143531440534993 0.402098940323138 1.24856919091512 0.454545454545455 18.3 18 3 abnormal vestibular ganglion morphology 0.143531440534993 0.402098940323138 1.24856919091512 0.454545454545455 18.3 18 3 abnormal nerve fiber response 0.143531440534993 0.402098940323138 1.24856919091512 0.454545454545455 18.3 18 3 abnormal coronal suture morphology 0.143531440534993 0.402098940323138 1.24856919091512 0.454545454545455 18.3 18 3 pharyngeal arch hypoplasia 0.143531440534993 0.402098940323138 1.24856919091512 0.454545454545455 18.3 18 3 abnormal dorsal-ventral polarity of the somites 0.143531440534993 0.402098940323138 1.24856919091512 0.454545454545455 18.3 18 3 increased circulating triiodothyronine level 0.143531440534993 0.402098940323138 1.24856919091512 0.454545454545455 18.3 18 3 abnormal palate development 0.143531440534993 0.402098940323138 1.24856919091512 0.454545454545455 18.3 18 3 increased number of Howell-Jolly bodies 0.143531440534993 0.402098940323138 1.24856919091512 0.454545454545455 18.3 18 3 abnormal pulmonary alveolar sac morphology 0.143531440534993 0.402098940323138 1.24856919091512 0.454545454545455 18.3 18 3 decreased core body temperature 0.143531440534993 0.402098940323138 1.24856919091512 0.454545454545455 18.3 18 3 abnormal brain ependyma motile cilium morphology 0.143531440534993 0.402098940323138 1.24856919091512 0.454545454545455 18.3 18 3 hypolactation 0.143531440534993 0.402098940323138 1.24856919091512 0.454545454545455 18.3 18 3 reduced sympathetic cervical ganglion size 0.143531440534993 0.402098940323138 1.24856919091512 0.454545454545455 18.3 18 3 increased or absent threshold for auditory brainstem response 6.57268950088088e-12 6.95726175891114e-10 1.24511294401985 0.453287197231834 18.3 18 3 decreased circulating HDL cholesterol level 4.42312636402462e-06 0.000125341406853218 1.24466741219351 0.453125 18.3 18 3 decreased startle reflex 1.13008359330963e-05 0.000275596366505657 1.2443005782966 0.452991452991453 18.3 18 3 abnormal cartilage morphology 0.00736196479227894 0.0531578735001273 1.24262362333933 0.452380952380952 18.3 18 3 abnormal vibrissa morphology 0.00736196479227894 0.0531578735001273 1.24262362333933 0.452380952380952 18.3 18 3 abnormal reproductive system morphology 0.00736196479227894 0.0531578735001273 1.24262362333933 0.452380952380952 18.3 18 3 abnormal testis morphology 1.44830920747805e-05 0.000335132014288526 1.24205491687556 0.452173913043478 18.3 18 3 abnormal seminiferous tubule morphology 1.11770306635727e-06 3.5874662936306e-05 1.2417277158964 0.452054794520548 18.3 18 3 decreased bone mineral content 6.932882235298e-09 4.10608203816756e-07 1.24136590712137 0.451923076923077 18.3 18 3 neonatal lethality, complete penetrance 1.1234684827442e-17 3.10514205647356e-15 1.24090253798844 0.451754385964912 18.3 18 3 abnormal CD8-positive, alpha beta T cell morphology 0.0204634736601019 0.106925548647792 1.24051390581244 0.451612903225806 18.3 18 3 decreased double-negative T cell number 0.0204634736601019 0.106925548647792 1.24051390581244 0.451612903225806 18.3 18 3 abnormal podocyte morphology 0.0204634736601019 0.106925548647792 1.24051390581244 0.451612903225806 18.3 18 3 small cranium 0.0204634736601019 0.106925548647792 1.24051390581244 0.451612903225806 18.3 18 3 preaxial polydactyly 0.0204634736601019 0.106925548647792 1.24051390581244 0.451612903225806 18.3 18 3 decreased susceptibility to bacterial infection induced morbidity/mortality 0.0204634736601019 0.106925548647792 1.24051390581244 0.451612903225806 18.3 18 3 impaired hematopoiesis 0.0035266313989171 0.0309982176848279 1.23877649137853 0.450980392156863 18.3 18 3 increased lung adenocarcinoma incidence 0.0035266313989171 0.0309982176848279 1.23877649137853 0.450980392156863 18.3 18 3 increased kidney weight 0.0035266313989171 0.0309982176848279 1.23877649137853 0.450980392156863 18.3 18 3 postnatal lethality, incomplete penetrance 1.87355753599211e-21 7.76745728463394e-19 1.2380179019778 0.450704225352113 18.3 18 3 abnormal retinal pigment epithelium morphology 0.00031903274734242 0.00440885532785705 1.23608349900596 0.45 18.3 18 3 increased susceptibility to weight loss 0.00958013613188595 0.0644941505495705 1.23608349900596 0.45 18.3 18 3 abnormal basioccipital bone morphology 0.0598474407447924 0.234550508954545 1.23608349900596 0.45 18.3 18 3 abnormal dopamine level 0.0598474407447924 0.234550508954545 1.23608349900596 0.45 18.3 18 3 abnormal trachea morphology 0.0598474407447924 0.234550508954545 1.23608349900596 0.45 18.3 18 3 abnormal lens epithelium morphology 0.0598474407447924 0.234550508954545 1.23608349900596 0.45 18.3 18 3 abnormal heart right ventricle morphology 0.0598474407447924 0.234550508954545 1.23608349900596 0.45 18.3 18 3 kidney atrophy 0.0598474407447924 0.234550508954545 1.23608349900596 0.45 18.3 18 3 decreased circulating VLDL cholesterol level 0.0598474407447924 0.234550508954545 1.23608349900596 0.45 18.3 18 3 increased urine calcium level 0.0598474407447924 0.234550508954545 1.23608349900596 0.45 18.3 18 3 abnormal neuron proliferation 0.0598474407447924 0.234550508954545 1.23608349900596 0.45 18.3 18 3 increased startle reflex 0.000157814039210181 0.00251642578548285 1.23454032360146 0.449438202247191 18.3 18 3 polydactyly 7.83531990896355e-05 0.00142786507498512 1.23328058857738 0.448979591836735 18.3 18 3 abnormal long bone hypertrophic chondrocyte zone 0.00456806867753713 0.0379650237421166 1.23328058857738 0.448979591836735 18.3 18 3 abnormal epidermis stratum corneum morphology 0.00456806867753713 0.0379650237421166 1.23328058857738 0.448979591836735 18.3 18 3 abnormal respiratory system physiology 0.00456806867753713 0.0379650237421166 1.23328058857738 0.448979591836735 18.3 18 3 abnormal microglial cell morphology 0.0268457617157167 0.13302257249075 1.23134754690249 0.448275862068966 18.3 18 3 decreased granulocyte number 0.0268457617157167 0.13302257249075 1.23134754690249 0.448275862068966 18.3 18 3 abnormal spinal nerve morphology 0.0268457617157167 0.13302257249075 1.23134754690249 0.448275862068966 18.3 18 3 decreased neuron apoptosis 0.0124735335073724 0.0789514366401749 1.22885494053225 0.447368421052632 18.3 18 3 decreased T cell number 6.20123789966838e-07 2.17261679935565e-05 1.22840596174506 0.447204968944099 18.3 18 3 abnormal liver morphology 1.57443982976301e-07 6.63799843480592e-06 1.22764345028525 0.446927374301676 18.3 18 3 pulmonary hypoplasia 0.00591842442401018 0.0457587729963137 1.22731694936762 0.446808510638298 18.3 18 3 abnormal angiogenesis 0.00067747178781723 0.00796790105056907 1.22494761162753 0.445945945945946 18.3 18 3 short tail 0.000333582443258643 0.00457182549645109 1.22450038723482 0.44578313253012 18.3 18 3 abnormal pulmonary alveolus morphology 8.19179863158384e-05 0.00148197084335017 1.22384504852076 0.445544554455446 18.3 18 3 abnormal cochlea morphology 0.0036767345577866 0.0320345961908727 1.22082320889478 0.444444444444444 18.3 18 3 abnormal mandible morphology 0.0036767345577866 0.0320345961908727 1.22082320889478 0.444444444444444 18.3 18 3 heart right ventricle hypertrophy 0.0162502499910922 0.0969364432921865 1.22082320889478 0.444444444444444 18.3 18 3 abnormal limb bone morphology 0.0162502499910922 0.0969364432921865 1.22082320889478 0.444444444444444 18.3 18 3 short radius 0.0162502499910922 0.0969364432921865 1.22082320889478 0.444444444444444 18.3 18 3 abnormal retinal blood vessel morphology 0.0162502499910922 0.0969364432921865 1.22082320889478 0.444444444444444 18.3 18 3 abnormal atrioventricular cushion morphology 0.0352654159541076 0.163216635845759 1.22082320889478 0.444444444444444 18.3 18 3 rectal prolapse 0.0352654159541076 0.163216635845759 1.22082320889478 0.444444444444444 18.3 18 3 abnormal type II pneumocyte morphology 0.0352654159541076 0.163216635845759 1.22082320889478 0.444444444444444 18.3 18 3 thick interventricular septum 0.0352654159541076 0.163216635845759 1.22082320889478 0.444444444444444 18.3 18 3 decreased bone ossification 0.0352654159541076 0.163216635845759 1.22082320889478 0.444444444444444 18.3 18 3 abnormal megakaryocyte differentiation 0.0798083857630933 0.267912765972597 1.22082320889478 0.444444444444444 18.3 18 3 abnormal heart shape 0.0798083857630933 0.267912765972597 1.22082320889478 0.444444444444444 18.3 18 3 abnormal stomach glandular epithelium morphology 0.0798083857630933 0.267912765972597 1.22082320889478 0.444444444444444 18.3 18 3 cortical renal glomerulopathies 0.0798083857630933 0.267912765972597 1.22082320889478 0.444444444444444 18.3 18 3 abnormal radius morphology 0.0798083857630933 0.267912765972597 1.22082320889478 0.444444444444444 18.3 18 3 abnormal white adipose tissue morphology 0.0798083857630933 0.267912765972597 1.22082320889478 0.444444444444444 18.3 18 3 decreased activity of thyroid 0.0798083857630933 0.267912765972597 1.22082320889478 0.444444444444444 18.3 18 3 atrioventricular block 0.0798083857630933 0.267912765972597 1.22082320889478 0.444444444444444 18.3 18 3 abnormal nervous system physiology 3.32497394131565e-05 0.000697963939158032 1.21816924539718 0.443478260869565 18.3 18 3 abnormal response to infection 0.000549007270863203 0.00694990120240315 1.21695984430967 0.443037974683544 18.3 18 3 dehydration 0.00111861490628373 0.0123394881568992 1.21646312600587 0.442857142857143 18.3 18 3 abnormal spleen morphology 4.33216558747224e-07 1.59648324427218e-05 1.21556103989092 0.442528735632184 18.3 18 3 abnormal behavior 1.941309405747e-10 1.60966904893189e-08 1.21533389590514 0.442446043165468 18.3 18 3 abnormal hair growth 0.00474744006151442 0.0392334124684954 1.21495386654432 0.442307692307692 18.3 18 3 abnormal brain wave pattern 0.00474744006151442 0.0392334124684954 1.21495386654432 0.442307692307692 18.3 18 3 abnormal organ of Corti morphology 0.00994156376539573 0.0666567112302477 1.21372539954074 0.441860465116279 18.3 18 3 abnormal left-right axis patterning 0.00994156376539573 0.0666567112302477 1.21372539954074 0.441860465116279 18.3 18 3 abnormal blood circulation 0.00994156376539573 0.0666567112302477 1.21372539954074 0.441860465116279 18.3 18 3 decreased B cell number 4.54200369196666e-08 2.19383188034312e-06 1.21341530107382 0.441747572815534 18.3 18 3 abnormal spleen red pulp morphology 0.0211834157566485 0.109550408928614 1.21184656765291 0.441176470588235 18.3 18 3 abnormal nervous system development 0.0211834157566485 0.109550408928614 1.21184656765291 0.441176470588235 18.3 18 3 decreased cytotoxic T cell cytolysis 0.0211834157566485 0.109550408928614 1.21184656765291 0.441176470588235 18.3 18 3 lethargy 0.000219600197752459 0.00328081376522066 1.21097786043595 0.440860215053763 18.3 18 3 azoospermia 1.77548742491658e-06 5.59053793605061e-05 1.20930600881087 0.440251572327044 18.3 18 3 increased body length 0.00613005691650298 0.046489379816467 1.20861497680583 0.44 18.3 18 3 decreased placenta weight 0.0463936391972857 0.197023746467743 1.20861497680583 0.44 18.3 18 3 abnormal preimplantation embryo development 0.0463936391972857 0.197023746467743 1.20861497680583 0.44 18.3 18 3 abnormal mammary gland development 0.0128891874829223 0.0813752636136273 1.20593512098143 0.439024390243902 18.3 18 3 Leydig cell hyperplasia 0.0128891874829223 0.0813752636136273 1.20593512098143 0.439024390243902 18.3 18 3 abnormal facial morphology 0.00380282449548161 0.0330752654982885 1.20475974561985 0.43859649122807 18.3 18 3 decreased grip strength 3.13445916789717e-08 1.60274026179276e-06 1.20409960329348 0.438356164383562 18.3 18 3 abnormal heart atrium morphology 0.0276318013595062 0.134905016450975 1.2017478462558 0.4375 18.3 18 3 abnormal mouth morphology 0.106842574726998 0.328517805480108 1.2017478462558 0.4375 18.3 18 3 abnormal intestinal absorption 0.106842574726998 0.328517805480108 1.2017478462558 0.4375 18.3 18 3 abnormal extraembryonic endoderm formation 0.106842574726998 0.328517805480108 1.2017478462558 0.4375 18.3 18 3 increased intestinal adenocarcinoma incidence 0.106842574726998 0.328517805480108 1.2017478462558 0.4375 18.3 18 3 abnormal epicardium morphology 0.106842574726998 0.328517805480108 1.2017478462558 0.4375 18.3 18 3 large intestinal inflammation 0.106842574726998 0.328517805480108 1.2017478462558 0.4375 18.3 18 3 bowed tibia 0.106842574726998 0.328517805480108 1.2017478462558 0.4375 18.3 18 3 bowed radius 0.106842574726998 0.328517805480108 1.2017478462558 0.4375 18.3 18 3 small epididymis 0.106842574726998 0.328517805480108 1.2017478462558 0.4375 18.3 18 3 impaired somite development 0.106842574726998 0.328517805480108 1.2017478462558 0.4375 18.3 18 3 abnormal intestinal epithelium morphology 0.00791530984689833 0.0564973694237004 1.2017478462558 0.4375 18.3 18 3 oligodactyly 0.00791530984689833 0.0564973694237004 1.2017478462558 0.4375 18.3 18 3 curly tail 0.00791530984689833 0.0564973694237004 1.2017478462558 0.4375 18.3 18 3 abnormal phalanx morphology 0.00791530984689833 0.0564973694237004 1.2017478462558 0.4375 18.3 18 3 abnormal skeletal muscle fiber morphology 0.00148342157975639 0.0154393773206863 1.199329842541 0.436619718309859 18.3 18 3 absent gastric milk in neonates 0.000931311112115611 0.0104588550401245 1.19734583949296 0.435897435897436 18.3 18 3 abnormal heart looping 0.0167142780138874 0.0985231435060307 1.19734583949296 0.435897435897436 18.3 18 3 failure of heart looping 0.0167142780138874 0.0985231435060307 1.19734583949296 0.435897435897436 18.3 18 3 decreased B-1 B cell number 0.0167142780138874 0.0985231435060307 1.19734583949296 0.435897435897436 18.3 18 3 decreased trabecular bone volume 0.0167142780138874 0.0985231435060307 1.19734583949296 0.435897435897436 18.3 18 3 abnormal T cell differentiation 0.000183459511893485 0.00285222209896903 1.19664849188696 0.435643564356436 18.3 18 3 abnormal circulating insulin level 0.061132260918479 0.235215002373885 1.19428357391881 0.434782608695652 18.3 18 3 abnormal B cell morphology 0.061132260918479 0.235215002373885 1.19428357391881 0.434782608695652 18.3 18 3 abnormal palatal shelf fusion at midline 0.061132260918479 0.235215002373885 1.19428357391881 0.434782608695652 18.3 18 3 hydroencephaly 7.38159803106434e-05 0.00137027799270691 1.19428357391881 0.434782608695652 18.3 18 3 abnormal coat appearance 0.00190066690246808 0.0191413316594711 1.19428357391881 0.434782608695652 18.3 18 3 abnormal coat/ hair morphology 0.00629931930824153 0.0469499612839135 1.192030208685 0.433962264150943 18.3 18 3 atrioventricular septal defect 0.00629931930824153 0.0469499612839135 1.192030208685 0.433962264150943 18.3 18 3 male infertility 3.84890403180061e-16 9.11823693248002e-14 1.19048465996598 0.433399602385686 18.3 18 3 increased metastatic potential 0.0360669800981079 0.163865959806472 1.19030262867241 0.433333333333333 18.3 18 3 abnormal enzyme/coenzyme activity 4.93134391000626e-06 0.000136296866401562 1.18971943287198 0.43312101910828 18.3 18 3 abnormal myocardial fiber morphology 0.000298022118165941 0.00418026310623399 1.18935869320162 0.43298969072165 18.3 18 3 internal hemorrhage 0.00243450004910563 0.022938707849054 1.18893603552812 0.432835820895522 18.3 18 3 decreased cardiac muscle contractility 0.000188561988626972 0.00292241711345541 1.18854182596727 0.432692307692308 18.3 18 3 abnormal pancreatic beta cell physiology 0.0216786473065678 0.111704885119663 1.18782798703276 0.432432432432432 18.3 18 3 abnormal chromosome morphology 0.0216786473065678 0.111704885119663 1.18782798703276 0.432432432432432 18.3 18 3 abnormal astrocyte morphology 0.0131952892064401 0.0830969162051134 1.18614073136936 0.431818181818182 18.3 18 3 lethality, incomplete penetrance 0.0131952892064401 0.0830969162051134 1.18614073136936 0.431818181818182 18.3 18 3 increased inflammatory response 0.000379624754308802 0.00502296051246354 1.18548358968993 0.431578947368421 18.3 18 3 abnormal gastrulation 0.00810506937811989 0.0572774072338215 1.18491664392729 0.431372549019608 18.3 18 3 abnormal cervical vertebrae morphology 0.00810506937811989 0.0572774072338215 1.18491664392729 0.431372549019608 18.3 18 3 abnormal gluconeogenesis 0.00810506937811989 0.0572774072338215 1.18491664392729 0.431372549019608 18.3 18 3 abnormal dendritic spine morphology 0.00810506937811989 0.0572774072338215 1.18491664392729 0.431372549019608 18.3 18 3 abnormal vertebrae morphology 0.000151953195199253 0.00243076252770509 1.18442251688645 0.431192660550459 18.3 18 3 abnormal enzyme/coenzyme level 0.00501287217480286 0.0410910681762274 1.18398802586778 0.431034482758621 18.3 18 3 increased monocyte cell number 0.000305269043327513 0.00424221645406251 1.1811464546057 0.43 18.3 18 3 decreased circulating creatinine level 0.0104257407239191 0.0696215571832183 1.17722238000568 0.428571428571429 18.3 18 3 abnormal midbrain development 0.028121978958049 0.13689515197289 1.17722238000568 0.428571428571429 18.3 18 3 holoprosencephaly 0.028121978958049 0.13689515197289 1.17722238000568 0.428571428571429 18.3 18 3 abnormal ovulation 0.0471090706808127 0.197023746467743 1.17722238000568 0.428571428571429 18.3 18 3 absent corpus callosum 0.0471090706808127 0.197023746467743 1.17722238000568 0.428571428571429 18.3 18 3 straub tail 0.0471090706808127 0.197023746467743 1.17722238000568 0.428571428571429 18.3 18 3 abnormal hormone level 0.0471090706808127 0.197023746467743 1.17722238000568 0.428571428571429 18.3 18 3 abnormal scapula morphology 0.0806972319881553 0.26836144996061 1.17722238000568 0.428571428571429 18.3 18 3 abnormal anxiety-related response 0.0806972319881553 0.26836144996061 1.17722238000568 0.428571428571429 18.3 18 3 abnormal associative learning 0.0806972319881553 0.26836144996061 1.17722238000568 0.428571428571429 18.3 18 3 dry skin 0.0806972319881553 0.26836144996061 1.17722238000568 0.428571428571429 18.3 18 3 decreased cochlear outer hair cell number 0.0806972319881553 0.26836144996061 1.17722238000568 0.428571428571429 18.3 18 3 increased bone ossification 0.0806972319881553 0.26836144996061 1.17722238000568 0.428571428571429 18.3 18 3 abnormal adrenal gland secretion 0.143704907717495 0.402098940323138 1.17722238000568 0.428571428571429 18.3 18 3 abnormal spleen periarteriolar lymphoid sheath morphology 0.143704907717495 0.402098940323138 1.17722238000568 0.428571428571429 18.3 18 3 abnormal endplate potential 0.143704907717495 0.402098940323138 1.17722238000568 0.428571428571429 18.3 18 3 absent otoliths 0.143704907717495 0.402098940323138 1.17722238000568 0.428571428571429 18.3 18 3 abnormal prepulse inhibition 0.143704907717495 0.402098940323138 1.17722238000568 0.428571428571429 18.3 18 3 amyloid beta deposits 0.143704907717495 0.402098940323138 1.17722238000568 0.428571428571429 18.3 18 3 failure of zygotic cell division 0.143704907717495 0.402098940323138 1.17722238000568 0.428571428571429 18.3 18 3 abnormal hair cuticle 0.143704907717495 0.402098940323138 1.17722238000568 0.428571428571429 18.3 18 3 vascular smooth muscle hypoplasia 0.143704907717495 0.402098940323138 1.17722238000568 0.428571428571429 18.3 18 3 skeletal muscle necrosis 0.143704907717495 0.402098940323138 1.17722238000568 0.428571428571429 18.3 18 3 abnormal positive T cell selection 0.143704907717495 0.402098940323138 1.17722238000568 0.428571428571429 18.3 18 3 decreased CNS synapse formation 0.143704907717495 0.402098940323138 1.17722238000568 0.428571428571429 18.3 18 3 sternebra fusion 0.143704907717495 0.402098940323138 1.17722238000568 0.428571428571429 18.3 18 3 increased stomach tumor incidence 0.143704907717495 0.402098940323138 1.17722238000568 0.428571428571429 18.3 18 3 decreased compact bone area 0.143704907717495 0.402098940323138 1.17722238000568 0.428571428571429 18.3 18 3 impaired glucose tolerance 3.15715669659679e-08 1.60274026179276e-06 1.17405780371534 0.42741935483871 18.3 18 3 abnormal craniofacial morphology 0.000311642285990457 0.00431871970139978 1.17341259884061 0.427184466019417 18.3 18 3 hypoactivity 1.09012297354045e-11 1.10680852925791e-09 1.173058905629 0.427055702917772 18.3 18 3 abnormal muscle physiology 0.000782601272244596 0.00909682553602071 1.17281330742139 0.426966292134831 18.3 18 3 abnormal developmental patterning 0.00124450133731076 0.0134303560805228 1.17243692317639 0.426829268292683 18.3 18 3 abnormal limb morphology 0.00198473053834654 0.0197346722229331 1.17199028053899 0.426666666666667 18.3 18 3 increased osteoclast cell number 0.00510417257620489 0.0410973397471492 1.17078947082532 0.426229508196721 18.3 18 3 abnormal skeleton morphology 0.000158469758974195 0.00251880846931828 1.17039790244043 0.426086956521739 18.3 18 3 abnormal osteoblast physiology 0.00824510799406283 0.0576925629683018 1.16995557519083 0.425925925925926 18.3 18 3 decreased platelet aggregation 0.00824510799406283 0.0576925629683018 1.16995557519083 0.425925925925926 18.3 18 3 perinatal lethality 0.021987339404932 0.1119621428245 1.16741219350563 0.425 18.3 18 3 increased bone mineral density 0.00020079642890773 0.0030832167710369 1.16680448283749 0.424778761061947 18.3 18 3 astrocytosis 0.00252938571467788 0.0237877011919139 1.16647149069056 0.424657534246575 18.3 18 3 abnormal neuron morphology 0.000501855461905703 0.00641833142154466 1.16533124485411 0.424242424242424 18.3 18 3 insulin resistance 6.49844683619043e-05 0.00121999143434141 1.16533124485411 0.424242424242424 18.3 18 3 abnormal vascular development 0.00405391024912473 0.0348328212252082 1.16533124485411 0.424242424242424 18.3 18 3 abnormal aorta morphology 0.0364845549351661 0.164263041450182 1.16533124485411 0.424242424242424 18.3 18 3 dextrocardia 0.0364845549351661 0.164263041450182 1.16533124485411 0.424242424242424 18.3 18 3 abnormal skeleton physiology 0.0364845549351661 0.164263041450182 1.16533124485411 0.424242424242424 18.3 18 3 dilated heart atrium 0.0364845549351661 0.164263041450182 1.16533124485411 0.424242424242424 18.3 18 3 abnormal T cell subpopulation ratio 0.0364845549351661 0.164263041450182 1.16533124485411 0.424242424242424 18.3 18 3 increased osteoblast cell number 0.0364845549351661 0.164263041450182 1.16533124485411 0.424242424242424 18.3 18 3 increased body weight 2.45291953962797e-07 9.68513865845171e-06 1.16495964688062 0.424107142857143 18.3 18 3 decreased IgG level 0.00025429727949827 0.00367770048111597 1.16308157063624 0.423423423423423 18.3 18 3 abnormal female meiosis 0.0105673308769639 0.0703250337994173 1.16212978539022 0.423076923076923 18.3 18 3 abnormal stomach morphology 0.061573588956094 0.235456268298668 1.16212978539022 0.423076923076923 18.3 18 3 abnormal kidney cortex morphology 0.061573588956094 0.235456268298668 1.16212978539022 0.423076923076923 18.3 18 3 increased leukemia incidence 0.061573588956094 0.235456268298668 1.16212978539022 0.423076923076923 18.3 18 3 pulmonary edema 0.061573588956094 0.235456268298668 1.16212978539022 0.423076923076923 18.3 18 3 albuminuria 0.0172331917330508 0.0993454563985258 1.15978204845004 0.422222222222222 18.3 18 3 lethality at weaning, complete penetrance 0.0172331917330508 0.0993454563985258 1.15978204845004 0.422222222222222 18.3 18 3 impaired coordination 2.70035552297115e-10 2.09910448855961e-08 1.15907637029461 0.421965317919075 18.3 18 3 cyanosis 2.31877391357017e-06 7.07723939878013e-05 1.15882828031809 0.421875 18.3 18 3 abnormal lipid level 0.00160594108893142 0.0165415257089727 1.15831117711402 0.421686746987952 18.3 18 3 kinked tail 0.000508983339949034 0.00649280029806781 1.15798672020167 0.42156862745098 18.3 18 3 abnormal axial skeleton morphology 0.00256182760121447 0.0240409507193651 1.15656935579505 0.421052631578947 18.3 18 3 increased bone marrow cell number 0.0283732755241646 0.13757996660109 1.15656935579505 0.421052631578947 18.3 18 3 abnormal retinal outer nuclear layer morphology 0.0283732755241646 0.13757996660109 1.15656935579505 0.421052631578947 18.3 18 3 abnormal compact bone morphology 0.0283732755241646 0.13757996660109 1.15656935579505 0.421052631578947 18.3 18 3 irregular coat pigmentation 0.10673388706239 0.328517805480108 1.15656935579505 0.421052631578947 18.3 18 3 abnormal nail morphology 0.10673388706239 0.328517805480108 1.15656935579505 0.421052631578947 18.3 18 3 enlarged adrenal glands 0.10673388706239 0.328517805480108 1.15656935579505 0.421052631578947 18.3 18 3 thin dermal layer 0.10673388706239 0.328517805480108 1.15656935579505 0.421052631578947 18.3 18 3 abnormal neurotransmitter level 0.10673388706239 0.328517805480108 1.15656935579505 0.421052631578947 18.3 18 3 abnormal neural crest cell migration 0.10673388706239 0.328517805480108 1.15656935579505 0.421052631578947 18.3 18 3 oliguria 0.10673388706239 0.328517805480108 1.15656935579505 0.421052631578947 18.3 18 3 decreased circulating magnesium level 0.10673388706239 0.328517805480108 1.15656935579505 0.421052631578947 18.3 18 3 seizures 0.000257812094974895 0.00371772513768145 1.15656935579505 0.421052631578947 18.3 18 3 absent vitelline blood vessels 0.00834110630672995 0.0582823088145808 1.15656935579505 0.421052631578947 18.3 18 3 abnormal dendritic cell physiology 0.000407185122740145 0.0053591163641064 1.15521822337006 0.420560747663551 18.3 18 3 abnormal epidermal layer morphology 0.0041009192845308 0.0349949801724541 1.15447412145485 0.420289855072464 18.3 18 3 abnormal lung morphology 0.000206519323081048 0.00316133425331758 1.15413958824086 0.420168067226891 18.3 18 3 enlarged liver 0.000644211144324386 0.00772277215184053 1.15367793240557 0.42 18.3 18 3 decreased respiratory quotient 0.0135364083085997 0.0850298375445501 1.15367793240557 0.42 18.3 18 3 abnormal mitochondrial ATP synthesis coupled electron transport 0.0473361791922233 0.197399406103362 1.15190576968298 0.419354838709677 18.3 18 3 abnormal spermatogenesis 5.81278801154205e-06 0.000158025247854763 1.14949793989685 0.418478260869565 18.3 18 3 abnormal contextual conditioning behavior 0.0106531184375087 0.0705715901818985 1.14868365564191 0.418181818181818 18.3 18 3 hunched posture 0.00258530826831363 0.0240409507193651 1.14741928177769 0.417721518987342 18.3 18 3 abnormal somite development 0.00258530826831363 0.0240409507193651 1.14741928177769 0.417721518987342 18.3 18 3 female infertility 7.08727522965802e-08 3.26474020995821e-06 1.14624284368974 0.417293233082707 18.3 18 3 short snout 0.000519341171072447 0.00660798548870952 1.14452175833886 0.416666666666667 18.3 18 3 decreased exploration in new environment 0.00205500847049938 0.020154915274123 1.14452175833886 0.416666666666667 18.3 18 3 abnormal long bone epiphyseal plate morphology 0.00839828549294601 0.0585995376260959 1.14452175833886 0.416666666666667 18.3 18 3 abnormal motor capabilities/coordination/movement 0.000133783059988108 0.00218219909324865 1.14452175833886 0.416666666666667 18.3 18 3 abnormal heart left ventricle morphology 0.00413232686102756 0.0352026132424865 1.14452175833886 0.416666666666667 18.3 18 3 abnormal hair shaft morphology 0.0173290088052732 0.0995517538178223 1.14452175833886 0.416666666666667 18.3 18 3 abnormal digestive system morphology 0.080532412983697 0.26836144996061 1.14452175833886 0.416666666666667 18.3 18 3 abnormal adrenal gland morphology 0.080532412983697 0.26836144996061 1.14452175833886 0.416666666666667 18.3 18 3 increased stereotypic behavior 0.080532412983697 0.26836144996061 1.14452175833886 0.416666666666667 18.3 18 3 abnormal startle reflex 0.080532412983697 0.26836144996061 1.14452175833886 0.416666666666667 18.3 18 3 hemolytic anemia 0.080532412983697 0.26836144996061 1.14452175833886 0.416666666666667 18.3 18 3 small lymph nodes 0.080532412983697 0.26836144996061 1.14452175833886 0.416666666666667 18.3 18 3 abnormal primitive streak formation 0.080532412983697 0.26836144996061 1.14452175833886 0.416666666666667 18.3 18 3 increased body temperature 0.080532412983697 0.26836144996061 1.14452175833886 0.416666666666667 18.3 18 3 abnormal rectum morphology 0.194389614427351 0.484907122590416 1.14452175833886 0.416666666666667 18.3 18 3 abnormal pilomotor reflex 0.194389614427351 0.484907122590416 1.14452175833886 0.416666666666667 18.3 18 3 impaired embryo implantation 0.194389614427351 0.484907122590416 1.14452175833886 0.416666666666667 18.3 18 3 small thyroid gland 0.194389614427351 0.484907122590416 1.14452175833886 0.416666666666667 18.3 18 3 loss of dopaminergic neurons 0.194389614427351 0.484907122590416 1.14452175833886 0.416666666666667 18.3 18 3 small intestinal inflammation 0.194389614427351 0.484907122590416 1.14452175833886 0.416666666666667 18.3 18 3 increased fear-related response 0.194389614427351 0.484907122590416 1.14452175833886 0.416666666666667 18.3 18 3 abnormal nucleotide metabolism 0.194389614427351 0.484907122590416 1.14452175833886 0.416666666666667 18.3 18 3 abnormal defecation 0.194389614427351 0.484907122590416 1.14452175833886 0.416666666666667 18.3 18 3 increased hepatocyte proliferation 0.194389614427351 0.484907122590416 1.14452175833886 0.416666666666667 18.3 18 3 abnormal amacrine cell morphology 0.194389614427351 0.484907122590416 1.14452175833886 0.416666666666667 18.3 18 3 abnormal patella morphology 0.194389614427351 0.484907122590416 1.14452175833886 0.416666666666667 18.3 18 3 hydrometra 0.194389614427351 0.484907122590416 1.14452175833886 0.416666666666667 18.3 18 3 increased skeletal muscle glycogen level 0.194389614427351 0.484907122590416 1.14452175833886 0.416666666666667 18.3 18 3 increased type II pneumocyte number 0.194389614427351 0.484907122590416 1.14452175833886 0.416666666666667 18.3 18 3 abnormal rib morphology 0.000134753863616612 0.00219085121402826 1.13943499496846 0.414814814814815 18.3 18 3 abnormal cholesterol homeostasis 0.028431863683022 0.137729816770238 1.13893872537135 0.414634146341463 18.3 18 3 abnormal spermiogenesis 0.0106904480469138 0.0707247061614311 1.13662850483307 0.413793103448276 18.3 18 3 abnormal circulating glucose level 0.0614125828914689 0.235456268298668 1.13662850483307 0.413793103448276 18.3 18 3 aphagia 0.0614125828914689 0.235456268298668 1.13662850483307 0.413793103448276 18.3 18 3 abnormal embryonic erythropoiesis 0.0614125828914689 0.235456268298668 1.13662850483307 0.413793103448276 18.3 18 3 blood in lymph vessels 0.0614125828914689 0.235456268298668 1.13662850483307 0.413793103448276 18.3 18 3 increased leukocyte cell number 8.63578272473276e-05 0.00153989315611274 1.13662850483307 0.413793103448276 18.3 18 3 abnormal cardiovascular system physiology 0.000169375914434148 0.0026835833576748 1.13591633158443 0.413533834586466 18.3 18 3 cachexia 0.000825590222436511 0.0094591057911056 1.13571774481317 0.413461538461538 18.3 18 3 abnormal neurocranium morphology 0.00414965999429421 0.0352296219652111 1.13536558427214 0.413333333333333 18.3 18 3 abnormal locomotor behavior 0.00164207313165969 0.0167605417370389 1.13456939522287 0.41304347826087 18.3 18 3 abnormal forelimb morphology 0.0221682867462408 0.112652938266137 1.13456939522287 0.41304347826087 18.3 18 3 decreased litter size 7.35248965372056e-08 3.35583816763851e-06 1.13393187730085 0.412811387900356 18.3 18 3 hyperactivity 7.38654863043547e-10 5.40412932888477e-08 1.13279889396773 0.412398921832884 18.3 18 3 overexpanded pulmonary alveoli 0.0471953523601285 0.197023746467743 1.13105679647605 0.411764705882353 18.3 18 3 thin skin 0.0471953523601285 0.197023746467743 1.13105679647605 0.411764705882353 18.3 18 3 increased susceptibility to weight gain 0.0471953523601285 0.197023746467743 1.13105679647605 0.411764705882353 18.3 18 3 abnormal bone marrow cavity morphology 0.141475829345334 0.402098940323138 1.13105679647605 0.411764705882353 18.3 18 3 abnormal cranial suture morphology 0.141475829345334 0.402098940323138 1.13105679647605 0.411764705882353 18.3 18 3 abnormal involuntary movement 0.141475829345334 0.402098940323138 1.13105679647605 0.411764705882353 18.3 18 3 abnormal melanosome morphology 0.141475829345334 0.402098940323138 1.13105679647605 0.411764705882353 18.3 18 3 common atrium 0.141475829345334 0.402098940323138 1.13105679647605 0.411764705882353 18.3 18 3 increased T cell proliferation 0.000828137518572919 0.0094591057911056 1.12954670729517 0.411214953271028 18.3 18 3 abnormal cranium morphology 0.000213339984077323 0.00322603775314493 1.12743934403529 0.41044776119403 18.3 18 3 abnormal circulating hormone level 0.0364838824878354 0.164263041450182 1.12691373128749 0.41025641025641 18.3 18 3 decreased circulating cholesterol level 1.83456028593623e-05 0.000412983593779762 1.12575910656281 0.409836065573771 18.3 18 3 increased sensitivity to xenobiotic induced morbidity/mortality 0.00082897891958232 0.0094591057911056 1.1237122718236 0.409090909090909 18.3 18 3 abnormal suckling behavior 0.0026093640481498 0.0241742758650749 1.1237122718236 0.409090909090909 18.3 18 3 hyperglycemia 0.0026093640481498 0.0241742758650749 1.1237122718236 0.409090909090909 18.3 18 3 decreased blood urea nitrogen level 0.028335189339416 0.13757996660109 1.1237122718236 0.409090909090909 18.3 18 3 abnormal basisphenoid bone morphology 0.105392043033418 0.328517805480108 1.1237122718236 0.409090909090909 18.3 18 3 abnormal oogenesis 0.105392043033418 0.328517805480108 1.1237122718236 0.409090909090909 18.3 18 3 testis hypoplasia 0.105392043033418 0.328517805480108 1.1237122718236 0.409090909090909 18.3 18 3 abnormal female reproductive system physiology 0.105392043033418 0.328517805480108 1.1237122718236 0.409090909090909 18.3 18 3 abnormal retinal layer morphology 0.105392043033418 0.328517805480108 1.1237122718236 0.409090909090909 18.3 18 3 abnormal limb posture 0.105392043033418 0.328517805480108 1.1237122718236 0.409090909090909 18.3 18 3 decreased circulating estradiol level 0.105392043033418 0.328517805480108 1.1237122718236 0.409090909090909 18.3 18 3 organ of Corti degeneration 0.022089883344138 0.11236929410745 1.12116417143398 0.408163265306122 18.3 18 3 abnormal skeleton development 0.00414773207538375 0.0352296219652111 1.11908794148688 0.407407407407407 18.3 18 3 impaired limb coordination 0.0172751471569847 0.0993570602381493 1.11908794148688 0.407407407407407 18.3 18 3 abnormal neuronal precursor proliferation 0.0172751471569847 0.0993570602381493 1.11908794148688 0.407407407407407 18.3 18 3 cryptorchism 0.0796604578949595 0.267912765972597 1.11908794148688 0.407407407407407 18.3 18 3 decreased caudal vertebrae number 0.0106451691520244 0.0705715901818985 1.11590871438038 0.40625 18.3 18 3 decreased eosinophil cell number 0.0106451691520244 0.0705715901818985 1.11590871438038 0.40625 18.3 18 3 abnormal lumbar vertebrae morphology 0.0608181219198718 0.234550508954545 1.11590871438038 0.40625 18.3 18 3 increased circulating insulin level 8.70993474923325e-05 0.00154756876347984 1.11590871438038 0.40625 18.3 18 3 decreased circulating chloride level 0.0467766522196887 0.197023746467743 1.11358873784321 0.405405405405405 18.3 18 3 skin inflammation 0.0467766522196887 0.197023746467743 1.11358873784321 0.405405405405405 18.3 18 3 increased trabecular bone volume 0.0467766522196887 0.197023746467743 1.11358873784321 0.405405405405405 18.3 18 3 abnormal muscle morphology 0.0361819999268617 0.163939389468249 1.11182113667203 0.404761904761905 18.3 18 3 abnormal spleen white pulp morphology 0.0361819999268617 0.163939389468249 1.11182113667203 0.404761904761905 18.3 18 3 abnormal cytotoxic T cell physiology 0.0361819999268617 0.163939389468249 1.11182113667203 0.404761904761905 18.3 18 3 no abnormal phenotype detected 1.36098501396439e-37 9.67271492067552e-35 1.11140648901977 0.404610951008646 18.3 18 3 increased respiratory quotient 0.028113693804533 0.13689515197289 1.11042962085642 0.404255319148936 18.3 18 3 abnormal motor coordination/ balance 0.00205802953954864 0.020154915274123 1.10983928081344 0.404040404040404 18.3 18 3 abnormal skin condition 0.021925161958078 0.111798502067275 1.10930570423612 0.403846153846154 18.3 18 3 increased macrophage cell number 0.0171513329388643 0.0993454563985258 1.10837896597026 0.403508771929825 18.3 18 3 abnormal trabecular bone morphology 0.000822523958104737 0.0094591057911056 1.10797400471123 0.403361344537815 18.3 18 3 decreased white adipose tissue amount 0.0105734925189878 0.0703250337994173 1.10694044687101 0.402985074626866 18.3 18 3 increased anxiety-related response 0.000331971823429628 0.0045623199490674 1.10664549871038 0.402877697841727 18.3 18 3 reduced fertility 0.000331971823429628 0.0045623199490674 1.10664549871038 0.402877697841727 18.3 18 3 obese 0.00656895769798041 0.0487042690722095 1.10587556909624 0.402597402597403 18.3 18 3 increased sensitivity to induced morbidity/mortality 4.41177539806242e-05 0.000899532073990186 1.1047123058749 0.402173913043478 18.3 18 3 decreased IgM level 0.00257785814744784 0.0240409507193651 1.10440450083007 0.402061855670103 18.3 18 3 abnormal neuron differentiation 0.00129157765445115 0.0138781832200745 1.10364598125533 0.401785714285714 18.3 18 3 abnormal inner ear vestibule morphology 0.103291595507971 0.325856491852984 1.0987408880053 0.4 18.3 18 3 abnormal nest building behavior 0.103291595507971 0.325856491852984 1.0987408880053 0.4 18.3 18 3 abnormal primitive streak morphology 0.103291595507971 0.325856491852984 1.0987408880053 0.4 18.3 18 3 abnormal feces composition 0.103291595507971 0.325856491852984 1.0987408880053 0.4 18.3 18 3 abnormal cochlear outer hair cell morphology 0.103291595507971 0.325856491852984 1.0987408880053 0.4 18.3 18 3 increased liver glycogen level 0.103291595507971 0.325856491852984 1.0987408880053 0.4 18.3 18 3 weight loss 8.51681507742337e-05 0.00152414226655328 1.0987408880053 0.4 18.3 18 3 liver inflammation 0.00101991951188555 0.0114024709474845 1.0987408880053 0.4 18.3 18 3 domed cranium 0.0104753559138928 0.0698591094793788 1.0987408880053 0.4 18.3 18 3 abnormal eating behavior 0.0169770845433737 0.0993454563985258 1.0987408880053 0.4 18.3 18 3 abnormal learning/memory/conditioning 0.0216898329699687 0.111704885119663 1.0987408880053 0.4 18.3 18 3 abnormal cartilage development 0.0357365210769929 0.163216635845759 1.0987408880053 0.4 18.3 18 3 abnormal cell migration 0.0357365210769929 0.163216635845759 1.0987408880053 0.4 18.3 18 3 decreased circulating phosphate level 0.0461482445431047 0.197023746467743 1.0987408880053 0.4 18.3 18 3 abnormal pancreatic beta cell morphology 0.0461482445431047 0.197023746467743 1.0987408880053 0.4 18.3 18 3 abnormal artery morphology 0.0599109346281814 0.234550508954545 1.0987408880053 0.4 18.3 18 3 decreased bone mineralization 0.0599109346281814 0.234550508954545 1.0987408880053 0.4 18.3 18 3 abnormal hair cycle 0.0783096514203762 0.264487790778256 1.0987408880053 0.4 18.3 18 3 disorganized myocardium 0.0783096514203762 0.264487790778256 1.0987408880053 0.4 18.3 18 3 abnormal synaptic transmission 0.0783096514203762 0.264487790778256 1.0987408880053 0.4 18.3 18 3 decreased paired-pulse facilitation 0.137991517940789 0.395014965940216 1.0987408880053 0.4 18.3 18 3 abnormal physiological neovascularization 0.137991517940789 0.395014965940216 1.0987408880053 0.4 18.3 18 3 nuclear cataracts 0.137991517940789 0.395014965940216 1.0987408880053 0.4 18.3 18 3 decreased hepatocyte number 0.18796163402177 0.483760542813401 1.0987408880053 0.4 18.3 18 3 absent egg cylinders 0.18796163402177 0.483760542813401 1.0987408880053 0.4 18.3 18 3 abnormal rostral migratory stream morphology 0.18796163402177 0.483760542813401 1.0987408880053 0.4 18.3 18 3 abnormal zygomatic bone morphology 0.18796163402177 0.483760542813401 1.0987408880053 0.4 18.3 18 3 abnormal Muller cell morphology 0.18796163402177 0.483760542813401 1.0987408880053 0.4 18.3 18 3 abnormal coronary vessel morphology 0.18796163402177 0.483760542813401 1.0987408880053 0.4 18.3 18 3 increased urine protein level 0.00816157082690457 0.0572774072338215 1.09169767718475 0.397435897435897 18.3 18 3 dermatitis 0.021397057296432 0.110540353115004 1.08926898379836 0.396551724137931 18.3 18 3 reduced male fertility 1.38735476348191e-05 0.000325473344506463 1.0890603515471 0.39647577092511 18.3 18 3 abnormal pancreatic islet morphology 0.0273910154752712 0.133860807455279 1.08837540792978 0.39622641509434 18.3 18 3 retinal degeneration 0.00398486886285063 0.0344152162730521 1.08729567042191 0.395833333333333 18.3 18 3 abnormal lymph node morphology 0.0351795219074963 0.163216635845759 1.08729567042191 0.395833333333333 18.3 18 3 small ovary 0.00503253183688314 0.0410910681762274 1.08666681231294 0.395604395604396 18.3 18 3 abnormal tail morphology 0.0165108063354817 0.097787216094073 1.0820932987931 0.393939393939394 18.3 18 3 belly spot 0.0766349404599308 0.261677616223736 1.0820932987931 0.393939393939394 18.3 18 3 absent vibrissae 0.0766349404599308 0.261677616223736 1.0820932987931 0.393939393939394 18.3 18 3 decreased systemic arterial blood pressure 0.0766349404599308 0.261677616223736 1.0820932987931 0.393939393939394 18.3 18 3 myeloid hyperplasia 0.0766349404599308 0.261677616223736 1.0820932987931 0.393939393939394 18.3 18 3 abnormal long bone morphology 0.0210578763072812 0.109251038449149 1.0807287423003 0.39344262295082 18.3 18 3 increased double-negative T cell number 0.0210578763072812 0.109251038449149 1.0807287423003 0.39344262295082 18.3 18 3 abnormal male meiosis 0.0210578763072812 0.109251038449149 1.0807287423003 0.39344262295082 18.3 18 3 abnormal seminal vesicle morphology 0.0269268059910549 0.13302257249075 1.07912051500521 0.392857142857143 18.3 18 3 cochlear inner hair cell degeneration 0.0345366222761491 0.162400468642572 1.07719694902481 0.392156862745098 18.3 18 3 decreased T cell proliferation 0.00060512157055152 0.00738362878532825 1.07646911324844 0.391891891891892 18.3 18 3 delayed wound healing 0.0444589574324763 0.196432782616847 1.07485521652693 0.391304347826087 18.3 18 3 abnormal lymphocyte physiology 0.0444589574324763 0.196432782616847 1.07485521652693 0.391304347826087 18.3 18 3 abnormal blood vessel physiology 0.133844760107307 0.389858127361742 1.07485521652693 0.391304347826087 18.3 18 3 abnormal carpal bone morphology 0.133844760107307 0.389858127361742 1.07485521652693 0.391304347826087 18.3 18 3 abnormal cochlear ganglion morphology 0.133844760107307 0.389858127361742 1.07485521652693 0.391304347826087 18.3 18 3 increased susceptibility to age related obesity 0.133844760107307 0.389858127361742 1.07485521652693 0.391304347826087 18.3 18 3 abnormal crista ampullaris morphology 0.133844760107307 0.389858127361742 1.07485521652693 0.391304347826087 18.3 18 3 abnormal corneal stroma morphology 0.133844760107307 0.389858127361742 1.07485521652693 0.391304347826087 18.3 18 3 abnormal basicranium morphology 0.133844760107307 0.389858127361742 1.07485521652693 0.391304347826087 18.3 18 3 abnormal hepatocyte physiology 0.133844760107307 0.389858127361742 1.07485521652693 0.391304347826087 18.3 18 3 increased sacral vertebrae number 0.0206815665830411 0.10773905104778 1.07298914844268 0.390625 18.3 18 3 increased bone trabecula number 0.0574867282935575 0.234550508954545 1.07194232976127 0.390243902439024 18.3 18 3 abnormal thoracic vertebrae morphology 0.0264132885348839 0.131933845844425 1.07080679763229 0.389830508474576 18.3 18 3 cochlear outer hair cell degeneration 0.0159317843689081 0.0954947316088166 1.06822030778293 0.388888888888889 18.3 18 3 abnormal retinal rod cell morphology 0.180718747988579 0.467781358607273 1.06822030778293 0.388888888888889 18.3 18 3 abnormal phrenic nerve morphology 0.180718747988579 0.467781358607273 1.06822030778293 0.388888888888889 18.3 18 3 abnormal thymus medulla morphology 0.180718747988579 0.467781358607273 1.06822030778293 0.388888888888889 18.3 18 3 decreased cellular sensitivity to gamma-irradiation 0.180718747988579 0.467781358607273 1.06822030778293 0.388888888888889 18.3 18 3 long tibia 0.180718747988579 0.467781358607273 1.06822030778293 0.388888888888889 18.3 18 3 abnormal eye anterior chamber morphology 0.180718747988579 0.467781358607273 1.06822030778293 0.388888888888889 18.3 18 3 jerky movement 0.180718747988579 0.467781358607273 1.06822030778293 0.388888888888889 18.3 18 3 impaired leukocyte tethering or rolling 0.180718747988579 0.467781358607273 1.06822030778293 0.388888888888889 18.3 18 3 rib fusion 0.0202759321703315 0.106925548647792 1.06594265254246 0.388059701492537 18.3 18 3 increased lung adenoma incidence 0.0978718444065781 0.314941243326452 1.06329763355352 0.387096774193548 18.3 18 3 abnormal intestine physiology 0.0978718444065781 0.314941243326452 1.06329763355352 0.387096774193548 18.3 18 3 abnormal spatial learning 0.000558710130482662 0.00705477893185595 1.06166680896218 0.386503067484663 18.3 18 3 increased liver weight 0.00952298634011756 0.0641962832548576 1.06128381227785 0.386363636363636 18.3 18 3 increased T cell number 0.00952298634011756 0.0641962832548576 1.06128381227785 0.386363636363636 18.3 18 3 osteoporosis 0.0560830170775041 0.230589264430234 1.06128381227785 0.386363636363636 18.3 18 3 decreased macrophage cell number 0.0560830170775041 0.230589264430234 1.06128381227785 0.386363636363636 18.3 18 3 decreased neutrophil cell number 0.00354724844830805 0.0310696497012897 1.05648162308202 0.384615384615385 18.3 18 3 increased B cell number 0.00354724844830805 0.0310696497012897 1.05648162308202 0.384615384615385 18.3 18 3 abnormal locomotor activation 0.00932766457611249 0.0633085010452383 1.05648162308202 0.384615384615385 18.3 18 3 absent corpus luteum 0.0424187849749436 0.189267672870264 1.05648162308202 0.384615384615385 18.3 18 3 acanthosis 0.0727132118652881 0.249826125020586 1.05648162308202 0.384615384615385 18.3 18 3 increased autoantibody level 0.0727132118652881 0.249826125020586 1.05648162308202 0.384615384615385 18.3 18 3 abnormal ureter morphology 0.129365349602894 0.379029808171024 1.05648162308202 0.384615384615385 18.3 18 3 abnormal membranous labyrinth morphology 0.250320558229797 0.53047591563629 1.05648162308202 0.384615384615385 18.3 18 3 abnormal renal/urinary system morphology 0.250320558229797 0.53047591563629 1.05648162308202 0.384615384615385 18.3 18 3 abnormal sympathetic ganglion morphology 0.250320558229797 0.53047591563629 1.05648162308202 0.384615384615385 18.3 18 3 tight skin 0.250320558229797 0.53047591563629 1.05648162308202 0.384615384615385 18.3 18 3 pup cannibalization 0.250320558229797 0.53047591563629 1.05648162308202 0.384615384615385 18.3 18 3 abnormal lung interstitium morphology 0.250320558229797 0.53047591563629 1.05648162308202 0.384615384615385 18.3 18 3 increased synaptic depression 0.250320558229797 0.53047591563629 1.05648162308202 0.384615384615385 18.3 18 3 abnormal soleus morphology 0.250320558229797 0.53047591563629 1.05648162308202 0.384615384615385 18.3 18 3 abnormal GABAergic neuron morphology 0.250320558229797 0.53047591563629 1.05648162308202 0.384615384615385 18.3 18 3 abnormal vestibulocochlear ganglion morphology 0.250320558229797 0.53047591563629 1.05648162308202 0.384615384615385 18.3 18 3 abnormal retinal inner plexiform layer morphology 0.250320558229797 0.53047591563629 1.05648162308202 0.384615384615385 18.3 18 3 increased circulating thyroid-stimulating hormone level 0.250320558229797 0.53047591563629 1.05648162308202 0.384615384615385 18.3 18 3 increased circulating ammonia level 0.250320558229797 0.53047591563629 1.05648162308202 0.384615384615385 18.3 18 3 abnormal hair follicle inner root sheath morphology 0.250320558229797 0.53047591563629 1.05648162308202 0.384615384615385 18.3 18 3 abnormal eye physiology 0.032279036962039 0.153820123454161 1.05296001767175 0.383333333333333 18.3 18 3 abnormal vision 0.0948594473788557 0.305849481989506 1.05026702529919 0.382352941176471 18.3 18 3 abnormal skin physiology 0.0948594473788557 0.305849481989506 1.05026702529919 0.382352941176471 18.3 18 3 decreased anxiety-related response 0.00340212766251642 0.0303870468959051 1.04961019789124 0.382113821138211 18.3 18 3 arrest of spermatogenesis 0.0145868247465926 0.0887157128536653 1.04641989333838 0.380952380952381 18.3 18 3 small ears 0.173249540065486 0.456832098617029 1.04641989333838 0.380952380952381 18.3 18 3 abnormal tumor vascularization 0.173249540065486 0.456832098617029 1.04641989333838 0.380952380952381 18.3 18 3 complete atrioventricular septal defect 0.173249540065486 0.456832098617029 1.04641989333838 0.380952380952381 18.3 18 3 abnormal CD4-positive, alpha-beta T cell physiology 0.0240651552736316 0.121796718134309 1.04457760479377 0.380281690140845 18.3 18 3 abnormal eye electrophysiology 0.0041779636328068 0.0354094873478941 1.04425786876537 0.380165289256198 18.3 18 3 decreased food intake 0.0184770588923327 0.105530956511066 1.04310843797972 0.379746835443038 18.3 18 3 thrombocytosis 0.0402057029033203 0.17971551836839 1.04190946276365 0.379310344827586 18.3 18 3 decreased retinal photoreceptor cell number 0.124746226349095 0.365927167503978 1.04190946276365 0.379310344827586 18.3 18 3 abnormal CD8-positive, alpha-beta T cell physiology 0.124746226349095 0.365927167503978 1.04190946276365 0.379310344827586 18.3 18 3 abnormal gait 1.0650172941321e-05 0.000262304967747691 1.04007025806327 0.378640776699029 18.3 18 3 abnormal T cell activation 0.0234405607333633 0.118996724131105 1.03934948865366 0.378378378378378 18.3 18 3 increased white adipose tissue amount 0.0917676506383995 0.296457183068856 1.03934948865366 0.378378378378378 18.3 18 3 abnormal long bone metaphysis morphology 0.0917676506383995 0.296457183068856 1.03934948865366 0.378378378378378 18.3 18 3 impaired skeletal muscle contractility 0.0917676506383995 0.296457183068856 1.03934948865366 0.378378378378378 18.3 18 3 abnormal calcium ion homeostasis 0.0917676506383995 0.296457183068856 1.03934948865366 0.378378378378378 18.3 18 3 abnormal respiratory electron transport chain 0.0917676506383995 0.296457183068856 1.03934948865366 0.378378378378378 18.3 18 3 irregular heartbeat 0.0684362467921003 0.247966241829299 1.03769972756056 0.377777777777778 18.3 18 3 improved glucose tolerance 0.000444959825608115 0.00582347087925777 1.03707685857643 0.377551020408163 18.3 18 3 increased lymphocyte cell number 0.0297887607136318 0.142225608973434 1.03504576406297 0.376811594202899 18.3 18 3 teratozoospermia 0.0170558604970709 0.0993454563985258 1.03006958250497 0.375 18.3 18 3 abnormal inflammatory response 0.0289451778164657 0.140080019102059 1.03006958250497 0.375 18.3 18 3 abnormal osteoclast morphology 0.0662591564193531 0.247966241829299 1.03006958250497 0.375 18.3 18 3 abnormal depression-related behavior 0.120104077898602 0.359040971864014 1.03006958250497 0.375 18.3 18 3 abnormal serotonin level 0.120104077898602 0.359040971864014 1.03006958250497 0.375 18.3 18 3 decreased body height 0.165832168381474 0.456832098617029 1.03006958250497 0.375 18.3 18 3 abnormal vasodilation 0.165832168381474 0.456832098617029 1.03006958250497 0.375 18.3 18 3 abnormal sensory capabilities/reflexes/nociception 0.165832168381474 0.456832098617029 1.03006958250497 0.375 18.3 18 3 prolonged QT interval 0.165832168381474 0.456832098617029 1.03006958250497 0.375 18.3 18 3 decreased fatty acid level 0.165832168381474 0.456832098617029 1.03006958250497 0.375 18.3 18 3 increased circulating total protein level 0.165832168381474 0.456832098617029 1.03006958250497 0.375 18.3 18 3 failure of tooth eruption 0.236633069598633 0.53047591563629 1.03006958250497 0.375 18.3 18 3 mixed cellular infiltration to dermis 0.236633069598633 0.53047591563629 1.03006958250497 0.375 18.3 18 3 poor circulation 0.236633069598633 0.53047591563629 1.03006958250497 0.375 18.3 18 3 decreased cochlear coiling 0.236633069598633 0.53047591563629 1.03006958250497 0.375 18.3 18 3 increased pancreatic beta cell number 0.236633069598633 0.53047591563629 1.03006958250497 0.375 18.3 18 3 decreased aggression towards mice 0.236633069598633 0.53047591563629 1.03006958250497 0.375 18.3 18 3 increased cochlear outer hair cell number 0.236633069598633 0.53047591563629 1.03006958250497 0.375 18.3 18 3 decreased circulating growth hormone level 0.236633069598633 0.53047591563629 1.03006958250497 0.375 18.3 18 3 loose skin 0.236633069598633 0.53047591563629 1.03006958250497 0.375 18.3 18 3 decreased creatinine clearance 0.236633069598633 0.53047591563629 1.03006958250497 0.375 18.3 18 3 impaired behavioral response to addictive substance 0.236633069598633 0.53047591563629 1.03006958250497 0.375 18.3 18 3 decreased skeletal muscle weight 0.236633069598633 0.53047591563629 1.03006958250497 0.375 18.3 18 3 decreased compact bone thickness 0.0367926817093399 0.165500534813712 1.0249448582139 0.373134328358209 18.3 18 3 abnormal excitatory postsynaptic currents 0.0272682049869086 0.133391661563294 1.02126556897929 0.371794871794872 18.3 18 3 increased circulating alanine transaminase level 0.0272682049869086 0.133391661563294 1.02126556897929 0.371794871794872 18.3 18 3 increased circulating serum albumin level 0.115510841276982 0.354294966308869 1.02025939600492 0.371428571428571 18.3 18 3 abnormal intestinal goblet cell morphology 0.115510841276982 0.354294966308869 1.02025939600492 0.371428571428571 18.3 18 3 abnormal trigeminal nerve morphology 0.158603521195797 0.441304540239984 1.01735267407898 0.37037037037037 18.3 18 3 wrinkled skin 0.158603521195797 0.441304540239984 1.01735267407898 0.37037037037037 18.3 18 3 decreased susceptibility to pharmacologically induced seizures 0.158603521195797 0.441304540239984 1.01735267407898 0.37037037037037 18.3 18 3 abnormal skin appearance 0.158603521195797 0.441304540239984 1.01735267407898 0.37037037037037 18.3 18 3 abnormal cytokine secretion 0.0031457954787235 0.0282496976654322 1.01669205545945 0.37012987012987 18.3 18 3 decreased heart rate 0.0151907566482342 0.0920511745736479 1.0163353214049 0.37 18.3 18 3 increased circulating cholesterol level 0.00181456569502025 0.0183858744047368 1.01446246761853 0.369318181818182 18.3 18 3 increased food intake 0.025626882593138 0.128468538540009 1.01371927167156 0.369047619047619 18.3 18 3 decreased threshold for auditory brainstem response 0.111011115103553 0.340913763975419 1.01199818632067 0.368421052631579 18.3 18 3 abnormal long term depression 0.223876583528855 0.53047591563629 1.01199818632067 0.368421052631579 18.3 18 3 decreased germ cell number 0.223876583528855 0.53047591563629 1.01199818632067 0.368421052631579 18.3 18 3 increased susceptibility to ischemic brain injury 0.223876583528855 0.53047591563629 1.01199818632067 0.368421052631579 18.3 18 3 abnormal cochlear inner hair cell morphology 0.223876583528855 0.53047591563629 1.01199818632067 0.368421052631579 18.3 18 3 abnormal blastocyst morphology 0.223876583528855 0.53047591563629 1.01199818632067 0.368421052631579 18.3 18 3 decreased susceptibility to weight gain 0.223876583528855 0.53047591563629 1.01199818632067 0.368421052631579 18.3 18 3 impaired natural killer cell mediated cytotoxicity 0.0598197348055643 0.234550508954545 1.01199818632067 0.368421052631579 18.3 18 3 abnormal estrous cycle 0.151630559202564 0.423085828397507 1.00717914733819 0.366666666666667 18.3 18 3 atelectasis 0.0423641587231843 0.189193617278135 1.00588954535697 0.366197183098592 18.3 18 3 reduced long term potentiation 0.0134331310171256 0.0844877709357772 1.00554411625485 0.366071428571429 18.3 18 3 short humerus 0.106632267623045 0.328517805480108 1.00494593415119 0.365853658536585 18.3 18 3 increased total body fat amount 0.00760052372964549 0.0548008776159222 1.00444596104962 0.365671641791045 18.3 18 3 increased susceptibility to injury 0.0765634820950931 0.261677616223736 1.00365754192792 0.365384615384615 18.3 18 3 short femur 0.0292653661949645 0.1400939706824 0.998855352732092 0.363636363636364 18.3 18 3 abnormal circadian rhythm 0.102390543380947 0.324247583271936 0.998855352732092 0.363636363636364 18.3 18 3 abnormal middle ear ossicle morphology 0.144943585006413 0.405336894551381 0.998855352732092 0.363636363636364 18.3 18 3 abnormal retinal outer plexiform layer morphology 0.21202525265524 0.515303190991607 0.998855352732092 0.363636363636364 18.3 18 3 increased adenoma incidence 0.21202525265524 0.515303190991607 0.998855352732092 0.363636363636364 18.3 18 3 impaired humoral immune response 0.21202525265524 0.515303190991607 0.998855352732092 0.363636363636364 18.3 18 3 cochlear ganglion degeneration 0.0709520231825138 0.247966241829299 0.994549941728937 0.362068965517241 18.3 18 3 abnormal humoral immune response 0.0203682360820189 0.106925548647792 0.994098898671463 0.361904761904762 18.3 18 3 abnormal tibia morphology 0.0982948757374837 0.314941243326452 0.99354229234522 0.361702127659574 18.3 18 3 hepatic necrosis 0.0982948757374837 0.314941243326452 0.99354229234522 0.361702127659574 18.3 18 3 abnormal NK cell physiology 0.0682769896362273 0.247966241829299 0.990668013775272 0.360655737704918 18.3 18 3 lung inflammation 0.0103656555970077 0.0694066441387796 0.98967469691654 0.360294117647059 18.3 18 3 decreased circulating alkaline phosphatase level 0.0943493329067455 0.304599566003283 0.988866799204771 0.36 18.3 18 3 abnormal thyroid gland morphology 0.20101124062282 0.489731107785763 0.988866799204771 0.36 18.3 18 3 increased pre-B cell number 0.20101124062282 0.489731107785763 0.988866799204771 0.36 18.3 18 3 abnormal vertebrae development 0.20101124062282 0.489731107785763 0.988866799204771 0.36 18.3 18 3 decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 0.20101124062282 0.489731107785763 0.988866799204771 0.36 18.3 18 3 abnormal response to injury 0.132457940916982 0.387862422638014 0.986049514876553 0.358974358974359 18.3 18 3 abnormal femur morphology 0.0631954900197841 0.237001379179458 0.983947063885345 0.358208955223881 18.3 18 3 abnormal stria vascularis morphology 0.190759299521242 0.484907122590416 0.981018650004734 0.357142857142857 18.3 18 3 rib bifurcation 0.190759299521242 0.484907122590416 0.981018650004734 0.357142857142857 18.3 18 3 megacephaly 0.309551475181076 0.569112560615615 0.981018650004734 0.357142857142857 18.3 18 3 abnormal kidney blood vessel morphology 0.309551475181076 0.569112560615615 0.981018650004734 0.357142857142857 18.3 18 3 abnormal pinna reflex 0.309551475181076 0.569112560615615 0.981018650004734 0.357142857142857 18.3 18 3 intestinal obstruction 0.309551475181076 0.569112560615615 0.981018650004734 0.357142857142857 18.3 18 3 abnormal sagittal suture morphology 0.309551475181076 0.569112560615615 0.981018650004734 0.357142857142857 18.3 18 3 abnormal decidualization 0.309551475181076 0.569112560615615 0.981018650004734 0.357142857142857 18.3 18 3 enlarged stomach 0.309551475181076 0.569112560615615 0.981018650004734 0.357142857142857 18.3 18 3 abnormal pancreas development 0.309551475181076 0.569112560615615 0.981018650004734 0.357142857142857 18.3 18 3 abnormal squamosal bone morphology 0.309551475181076 0.569112560615615 0.981018650004734 0.357142857142857 18.3 18 3 increased pulmonary respiratory rate 0.309551475181076 0.569112560615615 0.981018650004734 0.357142857142857 18.3 18 3 increased B cell proliferation 0.0834113371360811 0.277016957444595 0.977693163055565 0.355932203389831 18.3 18 3 abnormal ectoderm development 0.121123948395484 0.359040971864014 0.976658567115824 0.355555555555556 18.3 18 3 increased circulating corticosterone level 0.121123948395484 0.359040971864014 0.976658567115824 0.355555555555556 18.3 18 3 decreased osteoclast cell number 0.121123948395484 0.359040971864014 0.976658567115824 0.355555555555556 18.3 18 3 abnormal metabolism 0.121123948395484 0.359040971864014 0.976658567115824 0.355555555555556 18.3 18 3 absent mature ovarian follicles 0.181197852340356 0.4685339477096 0.974689497424058 0.354838709677419 18.3 18 3 decreased neuronal precursor cell number 0.181197852340356 0.4685339477096 0.974689497424058 0.354838709677419 18.3 18 3 abnormal response/metabolism to endogenous compounds 0.0520176678454509 0.216558910067881 0.971447736346151 0.353658536585366 18.3 18 3 deafness 0.0356871864885372 0.163216635845759 0.971109370711757 0.353535353535354 18.3 18 3 abnormal CNS synaptic transmission 0.0356871864885372 0.163216635845759 0.971109370711757 0.353535353535354 18.3 18 3 abnormal thrombosis 0.110855768090194 0.340646971123356 0.969477254122325 0.352941176470588 18.3 18 3 increased width of hypertrophic chondrocyte zone 0.172262205530536 0.456832098617029 0.969477254122325 0.352941176470588 18.3 18 3 decreased regulatory T cell number 0.172262205530536 0.456832098617029 0.969477254122325 0.352941176470588 18.3 18 3 abnormal interatrial septum morphology 0.288537018827705 0.537688396113728 0.969477254122325 0.352941176470588 18.3 18 3 distended urinary bladder 0.288537018827705 0.537688396113728 0.969477254122325 0.352941176470588 18.3 18 3 enlarged sebaceous gland 0.288537018827705 0.537688396113728 0.969477254122325 0.352941176470588 18.3 18 3 abnormal touch/ nociception 0.288537018827705 0.537688396113728 0.969477254122325 0.352941176470588 18.3 18 3 decreased vasoconstriction 0.288537018827705 0.537688396113728 0.969477254122325 0.352941176470588 18.3 18 3 absence seizures 0.288537018827705 0.537688396113728 0.969477254122325 0.352941176470588 18.3 18 3 increased circulating magnesium level 0.288537018827705 0.537688396113728 0.969477254122325 0.352941176470588 18.3 18 3 abnormal electroretinogram waveform feature 0.288537018827705 0.537688396113728 0.969477254122325 0.352941176470588 18.3 18 3 polyphagia 0.106089953897712 0.328517805480108 0.966485040375034 0.351851851851852 18.3 18 3 increased thermal nociceptive threshold 0.0462768754735021 0.197023746467743 0.965926055389276 0.351648351648352 18.3 18 3 abnormal breathing pattern 0.163894990571003 0.455772821738814 0.965110239464116 0.351351351351351 18.3 18 3 abnormal posture 0.062661852613237 0.237001379179458 0.961398277004639 0.35 18.3 18 3 waved hair 0.270122388076275 0.535828899792452 0.961398277004639 0.35 18.3 18 3 abnormal induced retinal neovascularization 0.270122388076275 0.535828899792452 0.961398277004639 0.35 18.3 18 3 abnormal heart electrocardiography waveform feature 0.270122388076275 0.535828899792452 0.961398277004639 0.35 18.3 18 3 decreased muscle cell glucose uptake 0.270122388076275 0.535828899792452 0.961398277004639 0.35 18.3 18 3 impaired macrophage phagocytosis 0.148669659873324 0.415056990948253 0.958204262795321 0.348837209302326 18.3 18 3 abnormal axon guidance 0.148669659873324 0.415056990948253 0.958204262795321 0.348837209302326 18.3 18 3 fragile skeleton 0.253721515347471 0.53047591563629 0.955426859135045 0.347826086956522 18.3 18 3 blistering 0.253721515347471 0.53047591563629 0.955426859135045 0.347826086956522 18.3 18 3 hypotension 0.253721515347471 0.53047591563629 0.955426859135045 0.347826086956522 18.3 18 3 abnormal postnatal growth 0.253721515347471 0.53047591563629 0.955426859135045 0.347826086956522 18.3 18 3 pancreas inflammation 0.253721515347471 0.53047591563629 0.955426859135045 0.347826086956522 18.3 18 3 decreased epididymis weight 0.253721515347471 0.53047591563629 0.955426859135045 0.347826086956522 18.3 18 3 dilated heart 0.253721515347471 0.53047591563629 0.955426859135045 0.347826086956522 18.3 18 3 increased circulating glucose level 0.0210596474116048 0.109251038449149 0.954579849508152 0.347517730496454 18.3 18 3 impaired righting response 0.0512171864304511 0.213404943460213 0.95416971853092 0.347368421052632 18.3 18 3 abnormal leukocyte migration 0.129010507734659 0.378212890972261 0.950833460773819 0.346153846153846 18.3 18 3 abnormal Schwann cell morphology 0.238941418221603 0.53047591563629 0.950833460773819 0.346153846153846 18.3 18 3 no spontaneous movement 0.238941418221603 0.53047591563629 0.950833460773819 0.346153846153846 18.3 18 3 increased circulating calcium level 0.123176643478356 0.36174958754712 0.948912585095488 0.345454545454545 18.3 18 3 abnormal platelet physiology 0.123176643478356 0.36174958754712 0.948912585095488 0.345454545454545 18.3 18 3 abnormal parietal bone morphology 0.225503022243426 0.53047591563629 0.947190420694225 0.344827586206897 18.3 18 3 abnormal vertebral body morphology 0.213199353238418 0.517650943075221 0.944230450629556 0.34375 18.3 18 3 abnormal lymphatic vessel morphology 0.213199353238418 0.517650943075221 0.944230450629556 0.34375 18.3 18 3 abnormal dermal layer morphology 0.201871612967172 0.491586526926912 0.941777904004544 0.342857142857143 18.3 18 3 abnormal reproductive system physiology 0.191394605814076 0.484907122590416 0.939712601583482 0.342105263157895 18.3 18 3 abnormal excitatory postsynaptic potential 0.0825955935089146 0.274491033872311 0.937949538541111 0.341463414634146 18.3 18 3 short ulna 0.181667406456733 0.469260304840212 0.937949538541111 0.341463414634146 18.3 18 3 hemopericardium 0.181667406456733 0.469260304840212 0.937949538541111 0.341463414634146 18.3 18 3 abnormal myelopoiesis 0.172607133921105 0.456832098617029 0.936426893186336 0.340909090909091 18.3 18 3 abnormal gametogenesis 0.172607133921105 0.456832098617029 0.936426893186336 0.340909090909091 18.3 18 3 abnormal photoreceptor outer segment morphology 0.172607133921105 0.456832098617029 0.936426893186336 0.340909090909091 18.3 18 3 cochlear hair cell degeneration 0.172607133921105 0.456832098617029 0.936426893186336 0.340909090909091 18.3 18 3 abnormal immune system physiology 0.0461145411589759 0.197023746467743 0.930385429359328 0.338709677419355 18.3 18 3 abnormal social investigation 0.0982510961985954 0.314941243326452 0.927062624254473 0.3375 18.3 18 3 decreased inflammatory response 0.106416920638123 0.328517805480108 0.915617406671085 0.333333333333333 18.3 18 3 abnormal nervous system electrophysiology 0.106416920638123 0.328517805480108 0.915617406671085 0.333333333333333 18.3 18 3 hyperkeratosis 0.133707694707178 0.389858127361742 0.915617406671085 0.333333333333333 18.3 18 3 skin lesions 0.146968386667682 0.410768384085236 0.915617406671085 0.333333333333333 18.3 18 3 abnormal ovarian follicle morphology 0.198348726683916 0.484907122590416 0.915617406671085 0.333333333333333 18.3 18 3 abnormal uterus morphology 0.233530943342606 0.53047591563629 0.915617406671085 0.333333333333333 18.3 18 3 salivary gland inflammation 0.262439253763856 0.53047591563629 0.915617406671085 0.333333333333333 18.3 18 3 abnormal spleen marginal zone morphology 0.262439253763856 0.53047591563629 0.915617406671085 0.333333333333333 18.3 18 3 increased vascular permeability 0.220862938262624 0.53047591563629 0.915617406671085 0.333333333333333 18.3 18 3 impaired macrophage chemotaxis 0.220862938262624 0.53047591563629 0.915617406671085 0.333333333333333 18.3 18 3 liver hemorrhage 0.262439253763856 0.53047591563629 0.915617406671085 0.333333333333333 18.3 18 3 abnormal bone trabecula morphology 0.279110366734506 0.537688396113728 0.915617406671085 0.333333333333333 18.3 18 3 abnormal cardiac muscle contractility 0.297666188830469 0.550311887562832 0.915617406671085 0.333333333333333 18.3 18 3 abnormal cellular extravasation 0.297666188830469 0.550311887562832 0.915617406671085 0.333333333333333 18.3 18 3 trunk curl 0.31855881208167 0.585024027355595 0.915617406671085 0.333333333333333 18.3 18 3 increased vasoconstriction 0.31855881208167 0.585024027355595 0.915617406671085 0.333333333333333 18.3 18 3 abnormal clavicle morphology 0.31855881208167 0.585024027355595 0.915617406671085 0.333333333333333 18.3 18 3 lowered ear position 0.342446154247268 0.621323711663077 0.915617406671085 0.333333333333333 18.3 18 3 right pulmonary isomerism 0.342446154247268 0.621323711663077 0.915617406671085 0.333333333333333 18.3 18 3 abnormal iron level 0.342446154247268 0.621323711663077 0.915617406671085 0.333333333333333 18.3 18 3 eye inflammation 0.342446154247268 0.621323711663077 0.915617406671085 0.333333333333333 18.3 18 3 absent allantois 0.342446154247268 0.621323711663077 0.915617406671085 0.333333333333333 18.3 18 3 abnormal sperm axoneme morphology 0.342446154247268 0.621323711663077 0.915617406671085 0.333333333333333 18.3 18 3 decreased salivation 0.370346395760729 0.654752423208823 0.915617406671085 0.333333333333333 18.3 18 3 abnormal enteric neuron morphology 0.370346395760729 0.654752423208823 0.915617406671085 0.333333333333333 18.3 18 3 abnormal pup retrieval 0.370346395760729 0.654752423208823 0.915617406671085 0.333333333333333 18.3 18 3 abnormal neurotransmitter secretion 0.370346395760729 0.654752423208823 0.915617406671085 0.333333333333333 18.3 18 3 abnormal dendritic cell morphology 0.370346395760729 0.654752423208823 0.915617406671085 0.333333333333333 18.3 18 3 ostium primum atrial septal defect 0.370346395760729 0.654752423208823 0.915617406671085 0.333333333333333 18.3 18 3 abnormal cued conditioning behavior 0.178904401041058 0.465020582643294 0.915617406671084 0.333333333333333 18.3 18 3 cardiovascular system phenotype 0.24732723735442 0.53047591563629 0.915617406671084 0.333333333333333 18.3 18 3 circling 0.119823288519191 0.359040971864014 0.904845437180837 0.329411764705882 18.3 18 3 maternal effect 0.158407090656906 0.441304540239984 0.901951475228233 0.328358208955224 18.3 18 3 increased circulating LDL cholesterol level 0.214031289082027 0.519417396674676 0.896931337147185 0.326530612244898 18.3 18 3 abnormal inner ear morphology 0.225745993798924 0.53047591563629 0.895712680439105 0.326086956521739 18.3 18 3 abnormal immune system morphology 0.225745993798924 0.53047591563629 0.895712680439105 0.326086956521739 18.3 18 3 abnormal sleep pattern 0.225745993798924 0.53047591563629 0.895712680439105 0.326086956521739 18.3 18 3 abnormal intestinal mucosa morphology 0.238384876489792 0.53047591563629 0.894323978608966 0.325581395348837 18.3 18 3 abnormal male reproductive system morphology 0.238384876489792 0.53047591563629 0.894323978608966 0.325581395348837 18.3 18 3 increased neutrophil cell number 0.0731001733334271 0.250982306648585 0.890358995452572 0.324137931034483 18.3 18 3 abnormal bone remodeling 0.283227904748452 0.537688396113728 0.888687482945464 0.323529411764706 18.3 18 3 increased susceptibility to viral infection induced morbidity/mortality 0.283227904748452 0.537688396113728 0.888687482945464 0.323529411764706 18.3 18 3 decreased monocyte cell number 0.186818268799361 0.482314938908573 0.887444563388897 0.323076923076923 18.3 18 3 reddish skin 0.320960872256578 0.58856628804883 0.88291678500426 0.321428571428571 18.3 18 3 abnormal spleen germinal center morphology 0.320960872256578 0.58856628804883 0.88291678500426 0.321428571428571 18.3 18 3 increased bone resorption 0.320960872256578 0.58856628804883 0.88291678500426 0.321428571428571 18.3 18 3 decreased circulating progesterone level 0.320960872256578 0.58856628804883 0.88291678500426 0.321428571428571 18.3 18 3 kidney inflammation 0.241235884701443 0.53047591563629 0.878992710404241 0.32 18.3 18 3 abnormal circulating protein level 0.241235884701443 0.53047591563629 0.878992710404241 0.32 18.3 18 3 abnormal egg cylinder morphology 0.343150870339951 0.622375348137534 0.878992710404241 0.32 18.3 18 3 abnormal innervation 0.254621621992373 0.53047591563629 0.876654963834017 0.319148936170213 18.3 18 3 impaired swimming 0.208599767669889 0.507722037259148 0.873998433640581 0.318181818181818 18.3 18 3 omphalocele 0.269081156355179 0.534616115362227 0.873998433640581 0.318181818181818 18.3 18 3 abnormal temporal bone morphology 0.368274473147337 0.65248059255983 0.873998433640581 0.318181818181818 18.3 18 3 decreased susceptibility to viral infection induced morbidity/mortality 0.368274473147337 0.65248059255983 0.873998433640581 0.318181818181818 18.3 18 3 abnormal sperm midpiece morphology 0.368274473147337 0.65248059255983 0.873998433640581 0.318181818181818 18.3 18 3 failure of palatal shelf elevation 0.368274473147337 0.65248059255983 0.873998433640581 0.318181818181818 18.3 18 3 increased tumor growth/size 0.28475876549032 0.537688396113728 0.870953142931032 0.317073170731707 18.3 18 3 increased grooming behavior 0.301830782915545 0.557389808836241 0.867427016846291 0.315789473684211 18.3 18 3 flaky skin 0.397170571501919 0.689693193065311 0.867427016846291 0.315789473684211 18.3 18 3 stereotypic behavior 0.397170571501919 0.689693193065311 0.867427016846291 0.315789473684211 18.3 18 3 delayed sexual maturation 0.397170571501919 0.689693193065311 0.867427016846291 0.315789473684211 18.3 18 3 osteoarthritis 0.397170571501919 0.689693193065311 0.867427016846291 0.315789473684211 18.3 18 3 increased circulating VLDL cholesterol level 0.397170571501919 0.689693193065311 0.867427016846291 0.315789473684211 18.3 18 3 decreased liver regeneration 0.397170571501919 0.689693193065311 0.867427016846291 0.315789473684211 18.3 18 3 decreased fertilization frequency 0.397170571501919 0.689693193065311 0.867427016846291 0.315789473684211 18.3 18 3 decreased liver glycogen level 0.397170571501919 0.689693193065311 0.867427016846291 0.315789473684211 18.3 18 3 right-sided stomach 0.397170571501919 0.689693193065311 0.867427016846291 0.315789473684211 18.3 18 3 decreased tumor growth/size 0.255759604332454 0.53047591563629 0.864749772967135 0.314814814814815 18.3 18 3 intraventricular hemorrhage 0.431125180379864 0.715330641623004 0.858391318754142 0.3125 18.3 18 3 paternal imprinting 0.431125180379864 0.715330641623004 0.858391318754142 0.3125 18.3 18 3 impaired muscle relaxation 0.431125180379864 0.715330641623004 0.858391318754142 0.3125 18.3 18 3 abnormal pulmonary elastic fiber morphology 0.431125180379864 0.715330641623004 0.858391318754142 0.3125 18.3 18 3 abnormal amnion morphology 0.431125180379864 0.715330641623004 0.858391318754142 0.3125 18.3 18 3 abnormal intestinal lipid absorption 0.431125180379864 0.715330641623004 0.858391318754142 0.3125 18.3 18 3 abnormal Langerhans cell physiology 0.431125180379864 0.715330641623004 0.858391318754142 0.3125 18.3 18 3 abnormal thoracic cage shape 0.431125180379864 0.715330641623004 0.858391318754142 0.3125 18.3 18 3 dilated respiratory conducting tubes 0.431125180379864 0.715330641623004 0.858391318754142 0.3125 18.3 18 3 embryonic lethality between somite formation and embryo turning, incomplete penetrance 0.431125180379864 0.715330641623004 0.858391318754142 0.3125 18.3 18 3 decreased midbrain size 0.431125180379864 0.715330641623004 0.858391318754142 0.3125 18.3 18 3 abnormal autopod morphology 0.301024834271233 0.556107891013512 0.854576246226346 0.311111111111111 18.3 18 3 abnormal middle ear morphology 0.363916904762497 0.646172676626098 0.852471378624803 0.310344827586207 18.3 18 3 enlarged epididymis 0.363916904762497 0.646172676626098 0.852471378624803 0.310344827586207 18.3 18 3 decreased body temperature 0.299326588095026 0.553175993972049 0.845185298465617 0.307692307692308 18.3 18 3 abnormal lens fiber morphology 0.337816491650176 0.614267926154834 0.845185298465617 0.307692307692308 18.3 18 3 decreased Peyer's patch number 0.38946618239255 0.687333897624312 0.845185298465617 0.307692307692308 18.3 18 3 increased eosinophil cell number 0.282298360697399 0.537688396113728 0.841777293229868 0.306451612903226 18.3 18 3 reduced long term depression 0.358789720342669 0.646172676626098 0.839315956115161 0.305555555555556 18.3 18 3 abnormal reflex 0.358789720342669 0.646172676626098 0.839315956115161 0.305555555555556 18.3 18 3 increased hemoglobin content 0.297077015575516 0.549631146332536 0.838022711190484 0.305084745762712 18.3 18 3 decreased sensitivity to xenobiotic induced morbidity/mortality 0.381859470730264 0.674387954165092 0.832379460610077 0.303030303030303 18.3 18 3 increased susceptibility to pharmacologically induced seizures 0.249883549135411 0.53047591563629 0.82977827479567 0.302083333333333 18.3 18 3 impaired fertilization 0.306023637663874 0.564713500511043 0.824055666003976 0.3 18.3 18 3 abnormal action potential 0.306023637663874 0.564713500511043 0.824055666003976 0.3 18.3 18 3 abnormal female reproductive system morphology 0.374564447468894 0.661739391391246 0.824055666003976 0.3 18.3 18 3 impaired ovarian folliculogenesis 0.374564447468894 0.661739391391246 0.824055666003976 0.3 18.3 18 3 arrested T cell differentiation 0.407407326619057 0.694602964335096 0.824055666003976 0.3 18.3 18 3 abnormal lactation 0.407407326619057 0.694602964335096 0.824055666003976 0.3 18.3 18 3 emphysema 0.407407326619057 0.694602964335096 0.824055666003976 0.3 18.3 18 3 abnormal pain threshold 0.407407326619057 0.694602964335096 0.824055666003976 0.3 18.3 18 3 abnormal fibula morphology 0.451619792970051 0.715330641623004 0.824055666003976 0.3 18.3 18 3 abnormal Peyer's patch T cell area morphology 0.451619792970051 0.715330641623004 0.824055666003976 0.3 18.3 18 3 abnormal thymocyte activation 0.451619792970051 0.715330641623004 0.824055666003976 0.3 18.3 18 3 enhanced behavioral response to xenobiotic 0.451619792970051 0.715330641623004 0.824055666003976 0.3 18.3 18 3 abnormal sperm mitochondrial sheath morphology 0.451619792970051 0.715330641623004 0.824055666003976 0.3 18.3 18 3 increased systemic arterial blood pressure 0.367617747274747 0.652246181416499 0.818211299578416 0.297872340425532 18.3 18 3 decreased bone trabecula number 0.367617747274747 0.652246181416499 0.818211299578416 0.297872340425532 18.3 18 3 abnormal vocalization 0.397642363279846 0.689693193065311 0.816631741085021 0.297297297297297 18.3 18 3 decreased sensitivity to induced morbidity/mortality 0.388786034996472 0.68637704900903 0.811569974094825 0.295454545454545 18.3 18 3 abnormal maternal nurturing 0.35470747397657 0.642866915494876 0.810546556725222 0.295081967213115 18.3 18 3 decreased susceptibility to injury 0.348691097981356 0.632193226114157 0.807897711768604 0.294117647058824 18.3 18 3 abnormal glutamate-mediated receptor currents 0.490536914359931 0.753914472950466 0.807897711768604 0.294117647058824 18.3 18 3 abnormal duodenum morphology 0.490536914359931 0.753914472950466 0.807897711768604 0.294117647058824 18.3 18 3 abnormal testis development 0.490536914359931 0.753914472950466 0.807897711768604 0.294117647058824 18.3 18 3 abnormal tendon morphology 0.490536914359931 0.753914472950466 0.807897711768604 0.294117647058824 18.3 18 3 abnormal survival 0.490536914359931 0.753914472950466 0.807897711768604 0.294117647058824 18.3 18 3 increased trabecular bone mass 0.490536914359931 0.753914472950466 0.807897711768604 0.294117647058824 18.3 18 3 abnormal cell cytoskeleton morphology 0.490536914359931 0.753914472950466 0.807897711768604 0.294117647058824 18.3 18 3 arrested B cell differentiation 0.411725419322097 0.701724549889495 0.803956747320952 0.292682926829268 18.3 18 3 decreased metastatic potential 0.468101770036553 0.722782838588408 0.801165230837199 0.291666666666667 18.3 18 3 apnea 0.468101770036553 0.722782838588408 0.801165230837199 0.291666666666667 18.3 18 3 abnormal osteoblast morphology 0.468101770036553 0.722782838588408 0.801165230837199 0.291666666666667 18.3 18 3 abnormal truncus arteriosus septation 0.468101770036553 0.722782838588408 0.801165230837199 0.291666666666667 18.3 18 3 abnormal T-helper 2 physiology 0.392663807753838 0.689693193065311 0.799084282185674 0.290909090909091 18.3 18 3 autoimmune response 0.450886200301997 0.715330641623004 0.797473225165138 0.290322580645161 18.3 18 3 abnormal T cell proliferation 0.450886200301997 0.715330641623004 0.797473225165138 0.290322580645161 18.3 18 3 altered response to myocardial infarction 0.424439022791099 0.715330641623004 0.793535085781607 0.288888888888889 18.3 18 3 increased fluid intake 0.436027784337419 0.715330641623004 0.784814920003787 0.285714285714286 18.3 18 3 decreased bone volume 0.463931857119144 0.717234614408869 0.784814920003787 0.285714285714286 18.3 18 3 increased circulating luteinizing hormone level 0.481920155676943 0.742276400771763 0.784814920003787 0.285714285714286 18.3 18 3 abnormal respiration 0.481920155676943 0.742276400771763 0.784814920003787 0.285714285714286 18.3 18 3 abnormal stapes morphology 0.504844185325405 0.76164018346691 0.784814920003787 0.285714285714286 18.3 18 3 decreased vocalization 0.504844185325405 0.76164018346691 0.784814920003787 0.285714285714286 18.3 18 3 increased dopamine level 0.49384909843985 0.758770619128553 0.772552186878728 0.28125 18.3 18 3 impaired conditioned place preference behavior 0.516693786585231 0.778011981919348 0.769118621603711 0.28 18.3 18 3 abnormal systemic arterial blood pressure 0.504371140494712 0.76164018346691 0.763014505559237 0.277777777777778 18.3 18 3 impaired wound healing 0.504371140494712 0.76164018346691 0.763014505559237 0.277777777777778 18.3 18 3 absent spleen 0.547494899018648 0.813313563039048 0.763014505559237 0.277777777777778 18.3 18 3 blepharoptosis 0.547494899018648 0.813313563039048 0.763014505559237 0.277777777777778 18.3 18 3 increased circulating glycerol level 0.547494899018648 0.813313563039048 0.763014505559237 0.277777777777778 18.3 18 3 abnormal macrophage chemotaxis 0.547494899018648 0.813313563039048 0.763014505559237 0.277777777777778 18.3 18 3 decreased fluid intake 0.547494899018648 0.813313563039048 0.763014505559237 0.277777777777778 18.3 18 3 decreased bone strength 0.526873775072923 0.786673778807861 0.75775233655538 0.275862068965517 18.3 18 3 increased double-positive T cell number 0.526873775072923 0.786673778807861 0.75775233655538 0.275862068965517 18.3 18 3 increased retinal apoptosis 0.526873775072923 0.786673778807861 0.75775233655538 0.275862068965517 18.3 18 3 abnormal ovarian folliculogenesis 0.535845208830945 0.799828957075893 0.749141514549069 0.272727272727273 18.3 18 3 abnormal long bone epiphysis morphology 0.55605782739218 0.82504852110829 0.749141514549069 0.272727272727273 18.3 18 3 intestinal ulcer 0.55605782739218 0.82504852110829 0.749141514549069 0.272727272727273 18.3 18 3 increased myocardial infarction size 0.55605782739218 0.82504852110829 0.749141514549069 0.272727272727273 18.3 18 3 increased bone volume 0.55605782739218 0.82504852110829 0.749141514549069 0.272727272727273 18.3 18 3 increased brown adipose tissue amount 0.543900317240958 0.809181841589045 0.742392491895474 0.27027027027027 18.3 18 3 decreased IgA level 0.537523202126533 0.799933571815585 0.739537136157414 0.269230769230769 18.3 18 3 increased percent body fat/body weight 0.537523202126533 0.799933571815585 0.739537136157414 0.269230769230769 18.3 18 3 increased susceptibility to otitis media 0.563567114445693 0.835442906545687 0.739537136157414 0.269230769230769 18.3 18 3 abnormal tectorial membrane morphology 0.563567114445693 0.835442906545687 0.739537136157414 0.269230769230769 18.3 18 3 gastrointestinal hemorrhage 0.570316119965238 0.836998364471022 0.732493925336868 0.266666666666667 18.3 18 3 abnormal inhibitory postsynaptic currents 0.562354242581403 0.834142026488515 0.727107940591744 0.264705882352941 18.3 18 3 increased susceptibility to bacterial infection induced morbidity/mortality 0.56775109711161 0.836998364471022 0.724863780281275 0.263888888888889 18.3 18 3 altered susceptibility to infection 0.601182158846051 0.836998364471022 0.722855847371909 0.263157894736842 18.3 18 3 abnormal response to novelty 0.601182158846051 0.836998364471022 0.722855847371909 0.263157894736842 18.3 18 3 maternal imprinting 0.601182158846051 0.836998364471022 0.722855847371909 0.263157894736842 18.3 18 3 hyporesponsive to tactile stimuli 0.582194462385703 0.836998364471022 0.722855847371909 0.263157894736842 18.3 18 3 decreased susceptibility to induced arthritis 0.575660126748373 0.836998364471022 0.722855847371909 0.263157894736842 18.3 18 3 bidirectional circling 0.604645980994793 0.836998364471022 0.716570144351284 0.260869565217391 18.3 18 3 abnormal ulna morphology 0.604645980994793 0.836998364471022 0.716570144351284 0.260869565217391 18.3 18 3 abnormal digestive system physiology 0.597294906845529 0.836998364471022 0.714181577203446 0.26 18.3 18 3 abnormal single cell response 0.608239478356792 0.839853290265069 0.712146871855288 0.259259259259259 18.3 18 3 increased circulating HDL cholesterol level 0.625934139888796 0.863806475990779 0.706333428003408 0.257142857142857 18.3 18 3 abnormal leukocyte adhesion 0.618980603178318 0.854447419759194 0.70432108205468 0.256410256410256 18.3 18 3 abnormal circulating cholesterol level 0.650345919250075 0.89650067837881 0.686713055003313 0.25 18.3 18 3 abnormal long term potentiation 0.651192915969696 0.896674441447339 0.686713055003313 0.25 18.3 18 3 abnormal diaphragm morphology 0.651192915969696 0.896674441447339 0.686713055003313 0.25 18.3 18 3 decreased skin tensile strength 0.651036280804717 0.896674441447339 0.686713055003313 0.25 18.3 18 3 abnormal incus morphology 0.651036280804717 0.896674441447339 0.686713055003313 0.25 18.3 18 3 head bobbing 0.654038766981127 0.898107332523077 0.686713055003313 0.25 18.3 18 3 enhanced long term potentiation 0.661760319576042 0.906209080619546 0.686713055003313 0.25 18.3 18 3 abnormal malleus morphology 0.650160717980873 0.896493783801231 0.686713055003313 0.25 18.3 18 3 abnormal impulse conducting system conduction 0.650160717980873 0.896493783801231 0.686713055003313 0.25 18.3 18 3 abnormal tumor morphology 0.650160717980873 0.896493783801231 0.686713055003313 0.25 18.3 18 3 increased susceptibility to parasitic infection 0.722090326171953 0.945368255975122 0.671452764892129 0.244444444444444 18.3 18 3 increased insulin secretion 0.687368940405134 0.930519858099467 0.668153242705927 0.243243243243243 18.3 18 3 abnormal humerus morphology 0.687368940405134 0.930519858099467 0.668153242705927 0.243243243243243 18.3 18 3 head tossing 0.688104182254097 0.931261780934203 0.665903568488061 0.242424242424242 18.3 18 3 stomach inflammation 0.689632510579169 0.932822659089551 0.663033294485958 0.241379310344828 18.3 18 3 absent long term depression 0.689632510579169 0.932822659089551 0.663033294485958 0.241379310344828 18.3 18 3 diaphragmatic hernia 0.692308170000549 0.933031472094302 0.659244532803181 0.24 18.3 18 3 increased incidence of induced tumors 0.696721310642002 0.933031472094302 0.654012433336489 0.238095238095238 18.3 18 3 increased acute inflammation 0.696721310642002 0.933031472094302 0.654012433336489 0.238095238095238 18.3 18 3 lung hemorrhage 0.722448441516921 0.945588265337196 0.646318169414883 0.235294117647059 18.3 18 3 abnormal food intake 0.784108597016244 1 0.636951239423363 0.231884057971014 18.3 18 3 small seminal vesicle 0.730930486667005 0.956438498466163 0.633888973849212 0.230769230769231 18.3 18 3 increased activated T cell number 0.738092923362538 0.960224987389105 0.624284595457558 0.227272727272727 18.3 18 3 abnormal body temperature homeostasis 0.759222220997511 0.986453525584387 0.620256952906219 0.225806451612903 18.3 18 3 head tilt 0.783204722174588 1 0.61041160444739 0.222222222222222 18.3 18 3 abnormal crypts of Lieberkuhn morphology 0.789470426405299 1 0.600873923127899 0.21875 18.3 18 3 failure of embryo implantation 0.77516151846469 1 0.597141786959403 0.217391304347826 18.3 18 3 abnormal regulatory T cell physiology 0.77516151846469 1 0.597141786959403 0.217391304347826 18.3 18 3 increased susceptibility to fungal infection 0.77516151846469 1 0.597141786959403 0.217391304347826 18.3 18 3 enhanced coordination 0.797523008075337 1 0.58861119000284 0.214285714285714 18.3 18 3 abnormal T-helper 1 physiology 0.842669114449723 1 0.584436642556011 0.212765957446809 18.3 18 3 decreased ovulation rate 0.808056465960431 1 0.572260879169428 0.208333333333333 18.3 18 3 decreased pancreatic beta cell number 0.841212830048705 1 0.565528398238023 0.205882352941176 18.3 18 3 decreased osteoblast cell number 0.841212830048705 1 0.565528398238023 0.205882352941176 18.3 18 3 abnormal energy expenditure 0.836993539950401 1 0.549370444002651 0.2 18.3 18 3 impaired behavioral response to xenobiotic 0.862977832293431 1 0.549370444002651 0.2 18.3 18 3 mammary gland hyperplasia 0.000744715120660026 0.00677323167327903 1.79762493814943 1 18.2 18 2 abnormal brain ventricular system morphology 0.000744715120660026 0.00677323167327903 1.79762493814943 1 18.2 18 2 decreased brain cholesterol level 0.000744715120660026 0.00677323167327903 1.79762493814943 1 18.2 18 2 aorta dilation 1.2135268303918e-05 0.00020396270206754 1.79762493814943 1 18.2 18 2 decreased transitional stage T2 B cell number 3.3967934075526e-05 0.000495097901593922 1.79762493814943 1 18.2 18 2 decreased transitional stage T1 B cell number 9.50748934696266e-05 0.00119665693520241 1.79762493814943 1 18.2 18 2 liver cysts 0.000266096722802101 0.00284083947626706 1.79762493814943 1 18.2 18 2 binucleate 0.000266096722802101 0.00284083947626706 1.79762493814943 1 18.2 18 2 abnormal olfactory bulb mitral cell layer morphology 0.000266096722802101 0.00284083947626706 1.79762493814943 1 18.2 18 2 abnormal hippocampal fimbria morphology 0.00208409632529264 0.0156858989687305 1.79762493814943 1 18.2 18 2 abnormal physical strength 0.00208409632529264 0.0156858989687305 1.79762493814943 1 18.2 18 2 abnormal olfactory bulb layer morphology 0.00208409632529264 0.0156858989687305 1.79762493814943 1 18.2 18 2 abnormal renal water reabsorbtion 0.00208409632529264 0.0156858989687305 1.79762493814943 1 18.2 18 2 myocardium hypoplasia 0.00208409632529264 0.0156858989687305 1.79762493814943 1 18.2 18 2 additional anastomosis between intracranial vertebral arteries 0.00208409632529264 0.0156858989687305 1.79762493814943 1 18.2 18 2 abnormal pineal gland morphology 0.00583206527989447 0.0357762327589088 1.79762493814943 1 18.2 18 2 optic nerve atrophy 0.00583206527989447 0.0357762327589088 1.79762493814943 1 18.2 18 2 decreased sensitivity to skin irradiation 0.00583206527989447 0.0357762327589088 1.79762493814943 1 18.2 18 2 increased hepatic hemangioma incidence 0.00583206527989447 0.0357762327589088 1.79762493814943 1 18.2 18 2 improved righting response 0.00583206527989447 0.0357762327589088 1.79762493814943 1 18.2 18 2 gastric polyps 0.00583206527989447 0.0357762327589088 1.79762493814943 1 18.2 18 2 absent uterus 0.00583206527989447 0.0357762327589088 1.79762493814943 1 18.2 18 2 abnormal response to vitamins 0.00583206527989447 0.0357762327589088 1.79762493814943 1 18.2 18 2 increased heart right ventricle weight 0.00583206527989447 0.0357762327589088 1.79762493814943 1 18.2 18 2 absent utricle 0.00583206527989447 0.0357762327589088 1.79762493814943 1 18.2 18 2 erythroblastosis 0.00583206527989447 0.0357762327589088 1.79762493814943 1 18.2 18 2 corneal deposits 0.00583206527989447 0.0357762327589088 1.79762493814943 1 18.2 18 2 abnormal cranium size 0.00583206527989447 0.0357762327589088 1.79762493814943 1 18.2 18 2 increased response to stress-induced hyperthermia 0.00583206527989447 0.0357762327589088 1.79762493814943 1 18.2 18 2 leptocytosis 0.00583206527989447 0.0357762327589088 1.79762493814943 1 18.2 18 2 increased renal carcinoma incidence 0.00583206527989447 0.0357762327589088 1.79762493814943 1 18.2 18 2 pale lung 0.00583206527989447 0.0357762327589088 1.79762493814943 1 18.2 18 2 abnormal lung alveolus development 0.00583206527989447 0.0357762327589088 1.79762493814943 1 18.2 18 2 abnormal eyelid margin morphology 0.00583206527989447 0.0357762327589088 1.79762493814943 1 18.2 18 2 decreased small intestinal villus height 0.00583206527989447 0.0357762327589088 1.79762493814943 1 18.2 18 2 heterochrony 5.53132050487057e-06 0.0001019197018953 1.67778327560614 0.933333333333333 18.2 18 2 midline facial cleft 1.44893766198326e-05 0.00023480341590771 1.66922315685304 0.928571428571429 18.2 18 2 abnormal embryonic growth/weight/body size 9.7936299276608e-05 0.00121808272225281 1.64782285997031 0.916666666666667 18.2 18 2 hematuria 9.7936299276608e-05 0.00121808272225281 1.64782285997031 0.916666666666667 18.2 18 2 abnormal pulmonary valve cusp morphology 9.7936299276608e-05 0.00121808272225281 1.64782285997031 0.916666666666667 18.2 18 2 abnormal eye distance/ position 0.000252294591791607 0.00274053623179748 1.63420448922676 0.909090909090909 18.2 18 2 pharyngeal arch hypoplasia 0.000252294591791607 0.00274053623179748 1.63420448922676 0.909090909090909 18.2 18 2 reduced sympathetic cervical ganglion size 0.000252294591791607 0.00274053623179748 1.63420448922676 0.909090909090909 18.2 18 2 increased skin tumor incidence 7.49269193249404e-07 1.74187581140924e-05 1.61786244433449 0.9 18.2 18 2 abnormal respiratory mechanics 0.000645037528016531 0.00596479870238335 1.61786244433449 0.9 18.2 18 2 abnormal plasma membrane morphology 0.000645037528016531 0.00596479870238335 1.61786244433449 0.9 18.2 18 2 abnormal respiratory conducting tube morphology 0.000645037528016531 0.00596479870238335 1.61786244433449 0.9 18.2 18 2 abnormal spinal cord dorsal column morphology 0.000645037528016531 0.00596479870238335 1.61786244433449 0.9 18.2 18 2 increased circulating fructosamine level 0.000645037528016531 0.00596479870238335 1.61786244433449 0.9 18.2 18 2 thin ventricle myocardium compact layer 0.000645037528016531 0.00596479870238335 1.61786244433449 0.9 18.2 18 2 fusion of atlas and odontoid process 0.000645037528016531 0.00596479870238335 1.61786244433449 0.9 18.2 18 2 abnormal adaptive thermogenesis 0.000645037528016531 0.00596479870238335 1.61786244433449 0.9 18.2 18 2 dilated uterus 0.00163427135746189 0.0131561488727717 1.59788883391061 0.888888888888889 18.2 18 2 decreased circulating bicarbonate level 0.00163427135746189 0.0131561488727717 1.59788883391061 0.888888888888889 18.2 18 2 pancreas cysts 0.00163427135746189 0.0131561488727717 1.59788883391061 0.888888888888889 18.2 18 2 decreased fear-related response 0.00163427135746189 0.0131561488727717 1.59788883391061 0.888888888888889 18.2 18 2 increased neuronal precursor cell number 0.00163427135746189 0.0131561488727717 1.59788883391061 0.888888888888889 18.2 18 2 positive geotaxis 0.00163427135746189 0.0131561488727717 1.59788883391061 0.888888888888889 18.2 18 2 prolonged RR interval 0.00163427135746189 0.0131561488727717 1.59788883391061 0.888888888888889 18.2 18 2 fusion of atlas and occipital bones 0.00163427135746189 0.0131561488727717 1.59788883391061 0.888888888888889 18.2 18 2 abnormal infrahyoid muscle connection 0.00163427135746189 0.0131561488727717 1.59788883391061 0.888888888888889 18.2 18 2 aminoaciduria 1.19002931154399e-05 0.000201374007650727 1.58613965130832 0.882352941176471 18.2 18 2 coloboma 1.19002931154399e-05 0.000201374007650727 1.58613965130832 0.882352941176471 18.2 18 2 increased sensitivity to skin irradiation 0.0040950439056655 0.026806372935113 1.57292182088075 0.875 18.2 18 2 early eyelid opening 0.0040950439056655 0.026806372935113 1.57292182088075 0.875 18.2 18 2 colon polyps 0.0040950439056655 0.026806372935113 1.57292182088075 0.875 18.2 18 2 elevated level of mitotic sister chromatid exchange 0.0040950439056655 0.026806372935113 1.57292182088075 0.875 18.2 18 2 tau protein deposits 0.0040950439056655 0.026806372935113 1.57292182088075 0.875 18.2 18 2 abnormal extraembryonic tissue physiology 0.0040950439056655 0.026806372935113 1.57292182088075 0.875 18.2 18 2 abnormal kidney epithelium morphology 0.0040950439056655 0.026806372935113 1.57292182088075 0.875 18.2 18 2 craniofacial phenotype 0.0040950439056655 0.026806372935113 1.57292182088075 0.875 18.2 18 2 abnormal base-excision repair 0.0040950439056655 0.026806372935113 1.57292182088075 0.875 18.2 18 2 abnormal sphingomyelin level 0.0040950439056655 0.026806372935113 1.57292182088075 0.875 18.2 18 2 abnormal olfactory bulb glomerular layer morphology 0.0040950439056655 0.026806372935113 1.57292182088075 0.875 18.2 18 2 abnormal brain ependyma morphology 0.0040950439056655 0.026806372935113 1.57292182088075 0.875 18.2 18 2 abnormal macrophage activation involved in immune response 0.0040950439056655 0.026806372935113 1.57292182088075 0.875 18.2 18 2 decreased cranium length 0.0040950439056655 0.026806372935113 1.57292182088075 0.875 18.2 18 2 absent hypoglossal canal 0.0040950439056655 0.026806372935113 1.57292182088075 0.875 18.2 18 2 abnormal umbilical vein topology 0.0040950439056655 0.026806372935113 1.57292182088075 0.875 18.2 18 2 embryo cyst 0.0040950439056655 0.026806372935113 1.57292182088075 0.875 18.2 18 2 increased brain apoptosis 0.0040950439056655 0.026806372935113 1.57292182088075 0.875 18.2 18 2 inner cell mass degeneration 4.94818167738206e-09 1.83710476455043e-07 1.56567333322692 0.870967741935484 18.2 18 2 persistence of hyaloid vascular system 1.05259767704669e-10 5.18482519139334e-09 1.56109534102451 0.868421052631579 18.2 18 2 increased lactate dehydrogenase level 0.000177481777030873 0.00198867531695629 1.54082137555666 0.857142857142857 18.2 18 2 amyloid beta deposits 0.000177481777030873 0.00198867531695629 1.54082137555666 0.857142857142857 18.2 18 2 absent olfactory bulb 0.000177481777030873 0.00198867531695629 1.54082137555666 0.857142857142857 18.2 18 2 abnormal renal tubule epithelial cell primary cilium morphology 0.000177481777030873 0.00198867531695629 1.54082137555666 0.857142857142857 18.2 18 2 testis degeneration 0.000177481777030873 0.00198867531695629 1.54082137555666 0.857142857142857 18.2 18 2 asymmetric rib joints 0.0101203835530883 0.054667652743338 1.54082137555666 0.857142857142857 18.2 18 2 cellular necrosis 0.0101203835530883 0.054667652743338 1.54082137555666 0.857142857142857 18.2 18 2 broad head 0.0101203835530883 0.054667652743338 1.54082137555666 0.857142857142857 18.2 18 2 abnormal oculomotor nerve morphology 0.0101203835530883 0.054667652743338 1.54082137555666 0.857142857142857 18.2 18 2 excessive tearing 0.0101203835530883 0.054667652743338 1.54082137555666 0.857142857142857 18.2 18 2 abnormal gastrulation movements 0.0101203835530883 0.054667652743338 1.54082137555666 0.857142857142857 18.2 18 2 decreased mortality induced by ionizing radiation 0.0101203835530883 0.054667652743338 1.54082137555666 0.857142857142857 18.2 18 2 aorta coarctation 0.0101203835530883 0.054667652743338 1.54082137555666 0.857142857142857 18.2 18 2 abnormal optic tract morphology 0.0101203835530883 0.054667652743338 1.54082137555666 0.857142857142857 18.2 18 2 urolithiasis 0.0101203835530883 0.054667652743338 1.54082137555666 0.857142857142857 18.2 18 2 retinal pigment epithelium atrophy 0.0101203835530883 0.054667652743338 1.54082137555666 0.857142857142857 18.2 18 2 uremia 0.0101203835530883 0.054667652743338 1.54082137555666 0.857142857142857 18.2 18 2 abnormal spinal cord central canal morphology 0.0101203835530883 0.054667652743338 1.54082137555666 0.857142857142857 18.2 18 2 decreased DN2 thymocyte number 0.0101203835530883 0.054667652743338 1.54082137555666 0.857142857142857 18.2 18 2 decreased DN4 thymocyte number 0.0101203835530883 0.054667652743338 1.54082137555666 0.857142857142857 18.2 18 2 abnormal retina inner limiting membrane morphology 0.0101203835530883 0.054667652743338 1.54082137555666 0.857142857142857 18.2 18 2 abnormal aortic valve cusp morphology 0.0101203835530883 0.054667652743338 1.54082137555666 0.857142857142857 18.2 18 2 small tail bud 0.0101203835530883 0.054667652743338 1.54082137555666 0.857142857142857 18.2 18 2 ductus venosus stenosis 0.0101203835530883 0.054667652743338 1.54082137555666 0.857142857142857 18.2 18 2 liver degeneration 3.47554400129516e-06 6.83432071400925e-05 1.54082137555666 0.857142857142857 18.2 18 2 absent ductus venosus valve 8.38256848237182e-06 0.00014736140706643 1.52798119742702 0.85 18.2 18 2 abnormal coping response 0.000428828916423056 0.00423298384762838 1.52106725535721 0.846153846153846 18.2 18 2 axonal dystrophy 0.000428828916423056 0.00423298384762838 1.52106725535721 0.846153846153846 18.2 18 2 absent hypoglossal nerve 0.000428828916423056 0.00423298384762838 1.52106725535721 0.846153846153846 18.2 18 2 kyphoscoliosis 2.00599090525997e-05 0.000312195949610264 1.51378942159952 0.842105263157895 18.2 18 2 increased liver adenoma incidence 2.00599090525997e-05 0.000312195949610264 1.51378942159952 0.842105263157895 18.2 18 2 abnormal sternebra morphology 2.00599090525997e-05 0.000312195949610264 1.51378942159952 0.842105263157895 18.2 18 2 abnormal brain vasculature morphology 1.1640388258497e-07 3.25342312281025e-06 1.49802078179119 0.833333333333333 18.2 18 2 abnormal corticospinal tract morphology 0.0010240860543666 0.00893829494819973 1.49802078179119 0.833333333333333 18.2 18 2 loss of dopaminergic neurons 0.0010240860543666 0.00893829494819973 1.49802078179119 0.833333333333333 18.2 18 2 abnormal fatty acid level 0.0010240860543666 0.00893829494819973 1.49802078179119 0.833333333333333 18.2 18 2 prenatal growth retardation 0.0010240860543666 0.00893829494819973 1.49802078179119 0.833333333333333 18.2 18 2 embryonic lethality between implantation and placentation, incomplete penetrance 0.0010240860543666 0.00893829494819973 1.49802078179119 0.833333333333333 18.2 18 2 echinocytosis 0.0245719100529037 0.108373450809571 1.49802078179119 0.833333333333333 18.2 18 2 absent organized vascular network 0.0245719100529037 0.108373450809571 1.49802078179119 0.833333333333333 18.2 18 2 hemoglobinuria 0.0245719100529037 0.108373450809571 1.49802078179119 0.833333333333333 18.2 18 2 abnormal lacrimal gland physiology 0.0245719100529037 0.108373450809571 1.49802078179119 0.833333333333333 18.2 18 2 increased embryo size 0.0245719100529037 0.108373450809571 1.49802078179119 0.833333333333333 18.2 18 2 delayed brain development 0.0245719100529037 0.108373450809571 1.49802078179119 0.833333333333333 18.2 18 2 abnormal internal nares morphology 0.0245719100529037 0.108373450809571 1.49802078179119 0.833333333333333 18.2 18 2 increased post-tetanic potentiation 0.0245719100529037 0.108373450809571 1.49802078179119 0.833333333333333 18.2 18 2 acidemia 0.0245719100529037 0.108373450809571 1.49802078179119 0.833333333333333 18.2 18 2 loss of hippocampal neurons 0.0245719100529037 0.108373450809571 1.49802078179119 0.833333333333333 18.2 18 2 bile duct inflammation 0.0245719100529037 0.108373450809571 1.49802078179119 0.833333333333333 18.2 18 2 increased glycerol level 0.0245719100529037 0.108373450809571 1.49802078179119 0.833333333333333 18.2 18 2 enlarged pancreas 0.0245719100529037 0.108373450809571 1.49802078179119 0.833333333333333 18.2 18 2 abnormal heart left atrium morphology 0.0245719100529037 0.108373450809571 1.49802078179119 0.833333333333333 18.2 18 2 abnormal cholesterol level 0.0245719100529037 0.108373450809571 1.49802078179119 0.833333333333333 18.2 18 2 abnormal heart size 0.0245719100529037 0.108373450809571 1.49802078179119 0.833333333333333 18.2 18 2 abnormal right lung morphology 0.0245719100529037 0.108373450809571 1.49802078179119 0.833333333333333 18.2 18 2 abnormal eyelid development 0.0245719100529037 0.108373450809571 1.49802078179119 0.833333333333333 18.2 18 2 delayed chorioallantoic fusion 0.0245719100529037 0.108373450809571 1.49802078179119 0.833333333333333 18.2 18 2 increased urine uric acid level 0.0245719100529037 0.108373450809571 1.49802078179119 0.833333333333333 18.2 18 2 absent sperm mitochondrial sheath 0.0245719100529037 0.108373450809571 1.49802078179119 0.833333333333333 18.2 18 2 cerebral arteriovenous malformation 0.0245719100529037 0.108373450809571 1.49802078179119 0.833333333333333 18.2 18 2 common truncal valve 0.0245719100529037 0.108373450809571 1.49802078179119 0.833333333333333 18.2 18 2 thick myocardium 0.0245719100529037 0.108373450809571 1.49802078179119 0.833333333333333 18.2 18 2 abnormal intestinal enteroendocrine cell morphology 0.0245719100529037 0.108373450809571 1.49802078179119 0.833333333333333 18.2 18 2 ectopic ureteric bud 0.0245719100529037 0.108373450809571 1.49802078179119 0.833333333333333 18.2 18 2 abnormal ureteric bud elongation 0.0245719100529037 0.108373450809571 1.49802078179119 0.833333333333333 18.2 18 2 delayed limb development 0.0245719100529037 0.108373450809571 1.49802078179119 0.833333333333333 18.2 18 2 thymus cortex atrophy 0.0245719100529037 0.108373450809571 1.49802078179119 0.833333333333333 18.2 18 2 absent thymus corticomedullary boundary 0.0245719100529037 0.108373450809571 1.49802078179119 0.833333333333333 18.2 18 2 abnormal Wolffian duct connection 0.0245719100529037 0.108373450809571 1.49802078179119 0.833333333333333 18.2 18 2 abnormal embryo morphology 0.0245719100529037 0.108373450809571 1.49802078179119 0.833333333333333 18.2 18 2 ectopic bone 0.0245719100529037 0.108373450809571 1.49802078179119 0.833333333333333 18.2 18 2 decreased tear production 0.0245719100529037 0.108373450809571 1.49802078179119 0.833333333333333 18.2 18 2 increased cardiac cell glucose uptake 0.0245719100529037 0.108373450809571 1.49802078179119 0.833333333333333 18.2 18 2 enlarged liver sinusoidal spaces 3.24360007849464e-08 1.00855689940693e-06 1.48039700788777 0.823529411764706 18.2 18 2 abnormal dorsal-ventral axis patterning 0.000111809615921455 0.00136003139170964 1.48039700788777 0.823529411764706 18.2 18 2 lymphoid hyperplasia 6.35655754979197e-07 1.51310401005814e-05 1.47662048490846 0.821428571428571 18.2 18 2 premature aging 6.35655754979197e-07 1.51310401005814e-05 1.47662048490846 0.821428571428571 18.2 18 2 embryonic lethality before implantation, incomplete penetrance 1.26768119441652e-05 0.000211634696047725 1.47078404030408 0.818181818181818 18.2 18 2 delayed hepatic development 0.00241238074102869 0.0178861314256598 1.47078404030408 0.818181818181818 18.2 18 2 abnormal proximal-distal axis patterning 0.00241238074102869 0.0178861314256598 1.47078404030408 0.818181818181818 18.2 18 2 abnormal fear/anxiety-related behavior 0.00241238074102869 0.0178861314256598 1.47078404030408 0.818181818181818 18.2 18 2 fatigue 0.00241238074102869 0.0178861314256598 1.47078404030408 0.818181818181818 18.2 18 2 increased glycogen level 0.00241238074102869 0.0178861314256598 1.47078404030408 0.818181818181818 18.2 18 2 common atrioventricular valve 0.00241238074102869 0.0178861314256598 1.47078404030408 0.818181818181818 18.2 18 2 blepharitis 0.000259853436939223 0.00281037141037529 1.46057026224641 0.8125 18.2 18 2 increased thymocyte apoptosis 3.37397317357894e-06 6.66091926133144e-05 1.45192783465916 0.807692307692308 18.2 18 2 abnormal postnatal growth/weight/body size 3.95816648693808e-07 9.8954162173452e-06 1.44969753076567 0.806451612903226 18.2 18 2 abnormal nose morphology 3.95816648693808e-07 9.8954162173452e-06 1.44969753076567 0.806451612903226 18.2 18 2 abnormal cell death 6.7705109933019e-10 3.034530828079e-08 1.44591571112019 0.804347826086957 18.2 18 2 abnormal optic cup morphology 8.98953568132232e-07 2.06096497763035e-05 1.43809995051954 0.8 18.2 18 2 anencephaly 6.67692713335113e-05 0.000885805666357916 1.43809995051954 0.8 18.2 18 2 vagina atresia 0.000596541919686023 0.0056102004734177 1.43809995051954 0.8 18.2 18 2 delayed intramembranous bone ossification 0.000596541919686023 0.0056102004734177 1.43809995051954 0.8 18.2 18 2 increased cranium width 0.00559120667524334 0.0354799148078261 1.43809995051954 0.8 18.2 18 2 abnormal mammary gland physiology 0.00559120667524334 0.0354799148078261 1.43809995051954 0.8 18.2 18 2 ketoaciduria 0.00559120667524334 0.0354799148078261 1.43809995051954 0.8 18.2 18 2 bifid ureter 0.00559120667524334 0.0354799148078261 1.43809995051954 0.8 18.2 18 2 ascites 0.00559120667524334 0.0354799148078261 1.43809995051954 0.8 18.2 18 2 osteosclerosis 0.00559120667524334 0.0354799148078261 1.43809995051954 0.8 18.2 18 2 abnormal hippocampus neuron morphology 0.00559120667524334 0.0354799148078261 1.43809995051954 0.8 18.2 18 2 abnormal inferior vena cava valve morphology 0.00559120667524334 0.0354799148078261 1.43809995051954 0.8 18.2 18 2 decreased circulating lactate level 0.00559120667524334 0.0354799148078261 1.43809995051954 0.8 18.2 18 2 abnormal outer ear morphology 2.02616650690418e-06 4.16353589646238e-05 1.425702537153 0.793103448275862 18.2 18 2 vertebral transformation 9.33936469919182e-10 4.07573152442801e-08 1.42311974270163 0.791666666666667 18.2 18 2 abnormal lung saccule morphology 1.73248511800212e-05 0.000277056731301099 1.42311974270163 0.791666666666667 18.2 18 2 small superior vagus ganglion 0.000150823754163185 0.00174906334956141 1.41917758274955 0.789473684210526 18.2 18 2 increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 0.000150823754163185 0.00174906334956141 1.41917758274955 0.789473684210526 18.2 18 2 embryonic lethality between implantation and somite formation, incomplete penetrance 0.000150823754163185 0.00174906334956141 1.41917758274955 0.789473684210526 18.2 18 2 abnormal cell nucleus morphology 2.08060151225097e-09 8.48442010118737e-08 1.41515154705381 0.787234042553192 18.2 18 2 spina bifida 1.71827541719341e-08 5.73719476546123e-07 1.41241959426027 0.785714285714286 18.2 18 2 abnormal placing response 0.0013504350941944 0.0112725077074113 1.41241959426027 0.785714285714286 18.2 18 2 increased hemangioma incidence 0.0013504350941944 0.0112725077074113 1.41241959426027 0.785714285714286 18.2 18 2 abnormal maternal decidual layer morphology 0.0013504350941944 0.0112725077074113 1.41241959426027 0.785714285714286 18.2 18 2 split sternum 0.0013504350941944 0.0112725077074113 1.41241959426027 0.785714285714286 18.2 18 2 increased circulating growth hormone level 0.0013504350941944 0.0112725077074113 1.41241959426027 0.785714285714286 18.2 18 2 failure to gastrulate 4.61001064349312e-09 1.72442127453972e-07 1.40683690811695 0.782608695652174 18.2 18 2 abnormal lysosome morphology 3.14892892925195e-07 8.03380585796332e-06 1.39815272967178 0.777777777777778 18.2 18 2 acidosis 0.000336581283038861 0.00341037043404956 1.39815272967178 0.777777777777778 18.2 18 2 decreased cellular sensitivity to gamma-irradiation 0.000336581283038861 0.00341037043404956 1.39815272967178 0.777777777777778 18.2 18 2 abnormal glycogen homeostasis 0.000336581283038861 0.00341037043404956 1.39815272967178 0.777777777777778 18.2 18 2 abnormal aerobic respiration 0.000336581283038861 0.00341037043404956 1.39815272967178 0.777777777777778 18.2 18 2 abnormal hypoglossal nerve topology 0.000336581283038861 0.00341037043404956 1.39815272967178 0.777777777777778 18.2 18 2 heart hyperplasia 0.0127077478243781 0.0660616984600639 1.39815272967178 0.777777777777778 18.2 18 2 distorted hair follicle pattern 0.0127077478243781 0.0660616984600639 1.39815272967178 0.777777777777778 18.2 18 2 abnormal kindling response 0.0127077478243781 0.0660616984600639 1.39815272967178 0.777777777777778 18.2 18 2 abnormal posterior semicircular canal morphology 0.0127077478243781 0.0660616984600639 1.39815272967178 0.777777777777778 18.2 18 2 polycythemia 0.0127077478243781 0.0660616984600639 1.39815272967178 0.777777777777778 18.2 18 2 biliary cyst 0.0127077478243781 0.0660616984600639 1.39815272967178 0.777777777777778 18.2 18 2 premature bone ossification 0.0127077478243781 0.0660616984600639 1.39815272967178 0.777777777777778 18.2 18 2 abnormal thymus physiology 0.0127077478243781 0.0660616984600639 1.39815272967178 0.777777777777778 18.2 18 2 liver hyperplasia 0.0127077478243781 0.0660616984600639 1.39815272967178 0.777777777777778 18.2 18 2 abnormal posterior eye segment morphology 0.0127077478243781 0.0660616984600639 1.39815272967178 0.777777777777778 18.2 18 2 trigeminal neuroma 0.0127077478243781 0.0660616984600639 1.39815272967178 0.777777777777778 18.2 18 2 increased cardiac muscle glycogen level 0.0127077478243781 0.0660616984600639 1.39815272967178 0.777777777777778 18.2 18 2 decreased fatty acid oxidation 0.0127077478243781 0.0660616984600639 1.39815272967178 0.777777777777778 18.2 18 2 cerebellum atrophy 0.0127077478243781 0.0660616984600639 1.39815272967178 0.777777777777778 18.2 18 2 decreased platelet dense granule number 0.0127077478243781 0.0660616984600639 1.39815272967178 0.777777777777778 18.2 18 2 abnormal eyelid morphology 2.62399443477826e-06 5.3066554117975e-05 1.39170962953504 0.774193548387097 18.2 18 2 pale kidney 2.62399443477826e-06 5.3066554117975e-05 1.39170962953504 0.774193548387097 18.2 18 2 abnormal Mullerian duct morphology 2.20327831892654e-05 0.000338312025822825 1.3827884139611 0.769230769230769 18.2 18 2 abnormal grip strength 0.00300827651417842 0.0217848262853532 1.3827884139611 0.769230769230769 18.2 18 2 abnormal tail bud morphology 0.00300827651417842 0.0217848262853532 1.3827884139611 0.769230769230769 18.2 18 2 increased synaptic depression 0.00300827651417842 0.0217848262853532 1.3827884139611 0.769230769230769 18.2 18 2 abnormal soleus morphology 0.00300827651417842 0.0217848262853532 1.3827884139611 0.769230769230769 18.2 18 2 increased cochlear inner hair cell number 0.00300827651417842 0.0217848262853532 1.3827884139611 0.769230769230769 18.2 18 2 decreased cardiac stroke volume 0.00300827651417842 0.0217848262853532 1.3827884139611 0.769230769230769 18.2 18 2 microcephaly 3.83124193737192e-12 2.6110176217021e-10 1.38078437278145 0.768115942028985 18.2 18 2 abnormal cell cycle 4.73630820119735e-19 9.06274357729108e-17 1.37557386571435 0.765217391304348 18.2 18 2 increased brain size 0.000740995855246964 0.00677323167327903 1.37465436446721 0.764705882352941 18.2 18 2 absent segment of posterior cerebral artery 0.000186871187514514 0.00208449362754419 1.3696190004948 0.761904761904762 18.2 18 2 increased B cell derived lymphoma incidence 7.40892306356724e-09 2.63281373151764e-07 1.36619495299357 0.76 18.2 18 2 abnormal cochlear outer hair cell morphology 4.78673472915228e-05 0.00065113976644862 1.36619495299357 0.76 18.2 18 2 abnormal preimplantation embryo development 4.78673472915228e-05 0.00065113976644862 1.36619495299357 0.76 18.2 18 2 abnormal spinal nerve morphology 1.23976883045687e-05 0.000207671714866091 1.36371547032026 0.758620689655172 18.2 18 2 kidney cysts 2.76702530559974e-12 2.02440454343511e-10 1.36036481805903 0.756756756756757 18.2 18 2 increased circulating phosphate level 8.50854149832066e-07 1.96883692809978e-05 1.36036481805903 0.756756756756757 18.2 18 2 abnormal cell differentiation 2.24737367802658e-07 5.96264097369936e-06 1.35917983128372 0.75609756097561 18.2 18 2 small superior cervical ganglion 2.65614801057451e-05 0.000394457801570394 1.34821870361207 0.75 18.2 18 2 abnormal mitotic spindle morphology 2.65614801057451e-05 0.000394457801570394 1.34821870361207 0.75 18.2 18 2 subcutaneous edema 2.65614801057451e-05 0.000394457801570394 1.34821870361207 0.75 18.2 18 2 abnormal trophoblast giant cell morphology 1.81606283044565e-06 3.76454690894462e-05 1.34821870361207 0.75 18.2 18 2 abnormal body weight 0.000102837786279121 0.00126325428824353 1.34821870361207 0.75 18.2 18 2 ocular hypertelorism 0.000102837786279121 0.00126325428824353 1.34821870361207 0.75 18.2 18 2 increased mammary adenocarcinoma incidence 0.000402987202652209 0.00403392622373187 1.34821870361207 0.75 18.2 18 2 spleen atrophy 0.000402987202652209 0.00403392622373187 1.34821870361207 0.75 18.2 18 2 vasculature congestion 0.00160660736792642 0.0131245839990705 1.34821870361207 0.75 18.2 18 2 disorganized yolk sac vascular plexus 0.00160660736792642 0.0131245839990705 1.34821870361207 0.75 18.2 18 2 intraventricular hemorrhage 0.00160660736792642 0.0131245839990705 1.34821870361207 0.75 18.2 18 2 increased cochlear outer hair cell number 0.00160660736792642 0.0131245839990705 1.34821870361207 0.75 18.2 18 2 decreased creatinine clearance 0.00160660736792642 0.0131245839990705 1.34821870361207 0.75 18.2 18 2 impaired somite development 0.00160660736792642 0.0131245839990705 1.34821870361207 0.75 18.2 18 2 decreased liver cholesterol level 0.00160660736792642 0.0131245839990705 1.34821870361207 0.75 18.2 18 2 abnormal thymus involution 0.00657726480101497 0.0393765251324302 1.34821870361207 0.75 18.2 18 2 myocarditis 0.00657726480101497 0.0393765251324302 1.34821870361207 0.75 18.2 18 2 interstitial pneumonia 0.00657726480101497 0.0393765251324302 1.34821870361207 0.75 18.2 18 2 dilated bile duct 0.00657726480101497 0.0393765251324302 1.34821870361207 0.75 18.2 18 2 absent ovary 0.00657726480101497 0.0393765251324302 1.34821870361207 0.75 18.2 18 2 increased osteosarcoma incidence 0.00657726480101497 0.0393765251324302 1.34821870361207 0.75 18.2 18 2 decreased red blood cell distribution width 0.00657726480101497 0.0393765251324302 1.34821870361207 0.75 18.2 18 2 persistent right dorsal aorta 0.00657726480101497 0.0393765251324302 1.34821870361207 0.75 18.2 18 2 abnormal vitelline vein connection 0.00657726480101497 0.0393765251324302 1.34821870361207 0.75 18.2 18 2 schistocytosis 0.0281964024953567 0.118377301615527 1.34821870361207 0.75 18.2 18 2 enlarged pituitary gland 0.0281964024953567 0.118377301615527 1.34821870361207 0.75 18.2 18 2 dermal cysts 0.0281964024953567 0.118377301615527 1.34821870361207 0.75 18.2 18 2 abnormal pupil morphology 0.0281964024953567 0.118377301615527 1.34821870361207 0.75 18.2 18 2 absent eyelids 0.0281964024953567 0.118377301615527 1.34821870361207 0.75 18.2 18 2 abnormal urination 0.0281964024953567 0.118377301615527 1.34821870361207 0.75 18.2 18 2 short ureter 0.0281964024953567 0.118377301615527 1.34821870361207 0.75 18.2 18 2 calcified muscle 0.0281964024953567 0.118377301615527 1.34821870361207 0.75 18.2 18 2 abnormal perineum morphology 0.0281964024953567 0.118377301615527 1.34821870361207 0.75 18.2 18 2 abnormal eyelid aperture 0.0281964024953567 0.118377301615527 1.34821870361207 0.75 18.2 18 2 increased left ventricle systolic pressure 0.0281964024953567 0.118377301615527 1.34821870361207 0.75 18.2 18 2 absent cochlear microphonics 0.0281964024953567 0.118377301615527 1.34821870361207 0.75 18.2 18 2 accumulation of giant lysosomes in kidney/renal tubule cells 0.0281964024953567 0.118377301615527 1.34821870361207 0.75 18.2 18 2 abnormal somite size 0.0281964024953567 0.118377301615527 1.34821870361207 0.75 18.2 18 2 stomach epithelial hyperplasia 0.0281964024953567 0.118377301615527 1.34821870361207 0.75 18.2 18 2 urinary bladder inflammation 0.0281964024953567 0.118377301615527 1.34821870361207 0.75 18.2 18 2 abnormal cerebellum deep nucleus morphology 0.0281964024953567 0.118377301615527 1.34821870361207 0.75 18.2 18 2 pleural effusion 0.0281964024953567 0.118377301615527 1.34821870361207 0.75 18.2 18 2 abnormal hepatic vein morphology 0.0281964024953567 0.118377301615527 1.34821870361207 0.75 18.2 18 2 myocardial trabeculae hypoplasia 0.0281964024953567 0.118377301615527 1.34821870361207 0.75 18.2 18 2 abnormal bronchiole epithelium morphology 0.0281964024953567 0.118377301615527 1.34821870361207 0.75 18.2 18 2 absent Reichert's membrane 0.0281964024953567 0.118377301615527 1.34821870361207 0.75 18.2 18 2 impaired neuron differentiation 0.0281964024953567 0.118377301615527 1.34821870361207 0.75 18.2 18 2 abnormal heart echocardiography feature 0.0281964024953567 0.118377301615527 1.34821870361207 0.75 18.2 18 2 retropleural edema 0.0281964024953567 0.118377301615527 1.34821870361207 0.75 18.2 18 2 decreased cell proliferation 4.19896578957826e-27 1.49213248593942e-24 1.3409310349439 0.745945945945946 18.2 18 2 delayed endochondral bone ossification 2.68322262857854e-07 6.95262113394699e-06 1.33776739583213 0.744186046511628 18.2 18 2 small liver 4.03084412752165e-12 2.70992561275948e-10 1.33669546682906 0.743589743589744 18.2 18 2 abnormal liver development 3.84347967560887e-06 7.3543505331362e-05 1.33537852548243 0.742857142857143 18.2 18 2 decreased glycogen level 3.84347967560887e-06 7.3543505331362e-05 1.33537852548243 0.742857142857143 18.2 18 2 abnormal embryonic neuroepithelium morphology 2.85760082148852e-09 1.12829873705598e-07 1.33272193690389 0.741379310344828 18.2 18 2 abnormal cranial nerve morphology 0.000218258003576973 0.00241296348398986 1.32867930211045 0.739130434782609 18.2 18 2 abnormal sacral vertebrae morphology 0.000218258003576973 0.00241296348398986 1.32867930211045 0.739130434782609 18.2 18 2 increased hepatocellular carcinoma incidence 5.96839176097414e-09 2.16735394239754e-07 1.32456574389958 0.736842105263158 18.2 18 2 abnormal forebrain development 6.51409818226637e-11 3.34099365533765e-09 1.32325169058222 0.736111111111111 18.2 18 2 enlarged kidney 2.2268180987547e-08 7.28843423770041e-07 1.32278061486468 0.735849056603774 18.2 18 2 trabecula carnea hypoplasia 3.1200135260911e-07 8.00106561458929e-06 1.31825828797625 0.733333333333333 18.2 18 2 delayed bone ossification 3.64912541360836e-11 1.97330423181539e-09 1.31825828797625 0.733333333333333 18.2 18 2 abnormal glial cell morphology 0.00342364132409243 0.0243323079819426 1.31825828797625 0.733333333333333 18.2 18 2 abnormal ear development 0.00342364132409243 0.0243323079819426 1.31825828797625 0.733333333333333 18.2 18 2 immune system phenotype 0.00342364132409243 0.0243323079819426 1.31825828797625 0.733333333333333 18.2 18 2 decreased thymocyte apoptosis 0.00342364132409243 0.0243323079819426 1.31825828797625 0.733333333333333 18.2 18 2 thick ventricular wall 1.17260466049095e-06 2.56991550041519e-05 1.31533532059714 0.731707317073171 18.2 18 2 heart inflammation 0.000117989735569079 0.00143170471818577 1.31364899326305 0.730769230769231 18.2 18 2 malocclusion 4.42212626810232e-06 8.33336294841252e-05 1.31178036027121 0.72972972972973 18.2 18 2 abnormal lung development 3.08897233088077e-12 2.22719381827998e-10 1.31120877841488 0.729411764705882 18.2 18 2 curly tail 1.7246346951101e-07 4.68855607003975e-06 1.31076818406729 0.729166666666667 18.2 18 2 decreased embryo size 7.17631848647409e-62 1.19007281567362e-58 1.30873112651883 0.728033472803347 18.2 18 2 abnormal head morphology 2.55708135586163e-08 8.15479470859718e-07 1.3073635913814 0.727272727272727 18.2 18 2 abnormal amino acid level 6.45425546484699e-07 1.52904385417208e-05 1.3073635913814 0.727272727272727 18.2 18 2 increased cardiomyocyte apoptosis 1.67461091033096e-05 0.000268748041254727 1.3073635913814 0.727272727272727 18.2 18 2 abnormal locomotor coordination 1.67461091033096e-05 0.000268748041254727 1.3073635913814 0.727272727272727 18.2 18 2 abnormal germ layer development 0.000457078358197466 0.00448513773576409 1.3073635913814 0.727272727272727 18.2 18 2 increased mammary gland tumor incidence 0.000457078358197466 0.00448513773576409 1.3073635913814 0.727272727272727 18.2 18 2 abnormal large intestine morphology 0.0140680758331491 0.0712715654479802 1.3073635913814 0.727272727272727 18.2 18 2 failure of somite differentiation 0.0140680758331491 0.0712715654479802 1.3073635913814 0.727272727272727 18.2 18 2 abnormal larynx morphology 0.0140680758331491 0.0712715654479802 1.3073635913814 0.727272727272727 18.2 18 2 abnormal radial glial cell morphology 0.0140680758331491 0.0712715654479802 1.3073635913814 0.727272727272727 18.2 18 2 abnormal coronal suture morphology 0.0140680758331491 0.0712715654479802 1.3073635913814 0.727272727272727 18.2 18 2 cyclopia 0.0140680758331491 0.0712715654479802 1.3073635913814 0.727272727272727 18.2 18 2 palatal shelf hypoplasia 0.0140680758331491 0.0712715654479802 1.3073635913814 0.727272727272727 18.2 18 2 abnormal pulmonary alveolar sac morphology 0.0140680758331491 0.0712715654479802 1.3073635913814 0.727272727272727 18.2 18 2 decreased embryonic cilium length 0.0140680758331491 0.0712715654479802 1.3073635913814 0.727272727272727 18.2 18 2 hypolactation 0.0140680758331491 0.0712715654479802 1.3073635913814 0.727272727272727 18.2 18 2 thin hypoglossal nerve 0.0140680758331491 0.0712715654479802 1.3073635913814 0.727272727272727 18.2 18 2 lethality throughout fetal growth and development, incomplete penetrance 8.64677609730625e-24 2.53045359318227e-21 1.3055376645778 0.726256983240223 18.2 18 2 abnormal gluconeogenesis 9.51576646699441e-08 2.73647041464146e-06 1.30415926885351 0.725490196078431 18.2 18 2 small lung 9.51576646699441e-08 2.73647041464146e-06 1.30415926885351 0.725490196078431 18.2 18 2 increased mortality induced by gamma-irradiation 6.37414335838333e-05 0.000854753725281862 1.30172840348752 0.724137931034483 18.2 18 2 polychromatophilia 6.37414335838333e-05 0.000854753725281862 1.30172840348752 0.724137931034483 18.2 18 2 pale yolk sac 1.2975434309525e-11 7.96947971480088e-10 1.29948790709597 0.72289156626506 18.2 18 2 renal hypoplasia 9.11476347303312e-06 0.000158552266707482 1.29828467755237 0.722222222222222 18.2 18 2 abnormal mammary gland morphology 0.00179247374298802 0.0141999313238303 1.29828467755237 0.722222222222222 18.2 18 2 abnormal bile duct morphology 0.00179247374298802 0.0141999313238303 1.29828467755237 0.722222222222222 18.2 18 2 abnormal metacarpal bone morphology 0.00179247374298802 0.0141999313238303 1.29828467755237 0.722222222222222 18.2 18 2 abnormal body wall morphology 0.00179247374298802 0.0141999313238303 1.29828467755237 0.722222222222222 18.2 18 2 absent inner cell mass 0.00179247374298802 0.0141999313238303 1.29828467755237 0.722222222222222 18.2 18 2 darkened coat color 0.00179247374298802 0.0141999313238303 1.29828467755237 0.722222222222222 18.2 18 2 primary atelectasis 0.00179247374298802 0.0141999313238303 1.29828467755237 0.722222222222222 18.2 18 2 increased effector memory CD4-positive, alpha-beta T cell number 0.00179247374298802 0.0141999313238303 1.29828467755237 0.722222222222222 18.2 18 2 abnormal placenta morphology 4.76914381378036e-11 2.55123553479111e-09 1.29702052499389 0.721518987341772 18.2 18 2 abnormal vasculogenesis 1.32467913367728e-06 2.8778509563513e-05 1.29596216471238 0.720930232558139 18.2 18 2 short stride length 1.94699630309003e-07 5.23584140966102e-06 1.29428995546759 0.72 18.2 18 2 kidney cortex cysts 3.44329394877381e-05 0.000495097901593922 1.2920429242949 0.71875 18.2 18 2 failure of primitive streak formation 3.44329394877381e-05 0.000495097901593922 1.2920429242949 0.71875 18.2 18 2 abnormal spongiotrophoblast layer morphology 3.44329394877381e-05 0.000495097901593922 1.2920429242949 0.71875 18.2 18 2 pancreatic islet hyperplasia 3.44329394877381e-05 0.000495097901593922 1.2920429242949 0.71875 18.2 18 2 increased fibroblast apoptosis 3.44329394877381e-05 0.000495097901593922 1.2920429242949 0.71875 18.2 18 2 increased embryonic tissue cell apoptosis 9.6926647627293e-11 4.87080880753316e-09 1.29060251969703 0.717948717948718 18.2 18 2 increased hepatocyte apoptosis 4.95816146979655e-06 9.23852183978945e-05 1.29060251969703 0.717948717948718 18.2 18 2 abnormal allantois morphology 7.24009356280343e-07 1.69105471713366e-05 1.2896004991072 0.717391304347826 18.2 18 2 pale liver 3.5560388181082e-10 1.68488505905603e-08 1.2874881313773 0.716216216216216 18.2 18 2 abnormal erythropoiesis 1.02583811044708e-13 9.8145088451427e-12 1.28401781296388 0.714285714285714 18.2 18 2 abnormal reproductive system morphology 2.69631748888569e-06 5.43084190575154e-05 1.28401781296388 0.714285714285714 18.2 18 2 decreased triglyceride level 1.86057750735854e-05 0.000293853114257421 1.28401781296388 0.714285714285714 18.2 18 2 abnormal brainstem morphology 0.000130662892883976 0.00155886784675727 1.28401781296388 0.714285714285714 18.2 18 2 trunk curl 0.00094327724049644 0.00842514231861722 1.28401781296388 0.714285714285714 18.2 18 2 translucent skin 0.00715288006413847 0.041378579440801 1.28401781296388 0.714285714285714 18.2 18 2 irregularly shaped pupil 0.00715288006413847 0.041378579440801 1.28401781296388 0.714285714285714 18.2 18 2 abnormal ventral body wall morphology 0.00715288006413847 0.041378579440801 1.28401781296388 0.714285714285714 18.2 18 2 failure of zygotic cell division 0.00715288006413847 0.041378579440801 1.28401781296388 0.714285714285714 18.2 18 2 decreased CNS synapse formation 0.00715288006413847 0.041378579440801 1.28401781296388 0.714285714285714 18.2 18 2 lysosomal protein accumulation 0.00715288006413847 0.041378579440801 1.28401781296388 0.714285714285714 18.2 18 2 abnormal viscerocranium morphology 0.00715288006413847 0.041378579440801 1.28401781296388 0.714285714285714 18.2 18 2 spina bifida occulta 0.00715288006413847 0.041378579440801 1.28401781296388 0.714285714285714 18.2 18 2 abnormal renal reabsorbtion 0.00715288006413847 0.041378579440801 1.28401781296388 0.714285714285714 18.2 18 2 multiple persisting craniopharyngeal ducts 0.00715288006413847 0.041378579440801 1.28401781296388 0.714285714285714 18.2 18 2 abnormal vitelline vein topology 0.00715288006413847 0.041378579440801 1.28401781296388 0.714285714285714 18.2 18 2 maxilla hypoplasia 0.0607007263024421 0.197634890938907 1.28401781296388 0.714285714285714 18.2 18 2 absent epidermis stratum corneum 0.0607007263024421 0.197634890938907 1.28401781296388 0.714285714285714 18.2 18 2 abnormal circulating free fatty acids level 0.0607007263024421 0.197634890938907 1.28401781296388 0.714285714285714 18.2 18 2 abnormal circulating alanine transaminase level 0.0607007263024421 0.197634890938907 1.28401781296388 0.714285714285714 18.2 18 2 abnormal axial mesoderm 0.0607007263024421 0.197634890938907 1.28401781296388 0.714285714285714 18.2 18 2 decreased urine calcium level 0.0607007263024421 0.197634890938907 1.28401781296388 0.714285714285714 18.2 18 2 decreased cardiomyocyte apoptosis 0.0607007263024421 0.197634890938907 1.28401781296388 0.714285714285714 18.2 18 2 increased cell nucleus count 0.0607007263024421 0.197634890938907 1.28401781296388 0.714285714285714 18.2 18 2 abnormal hard palate morphology 0.0607007263024421 0.197634890938907 1.28401781296388 0.714285714285714 18.2 18 2 abnormal central pattern generator function 0.0607007263024421 0.197634890938907 1.28401781296388 0.714285714285714 18.2 18 2 renal necrosis 0.0607007263024421 0.197634890938907 1.28401781296388 0.714285714285714 18.2 18 2 absent vestibular saccule 0.0607007263024421 0.197634890938907 1.28401781296388 0.714285714285714 18.2 18 2 abnormal talus morphology 0.0607007263024421 0.197634890938907 1.28401781296388 0.714285714285714 18.2 18 2 abnormal renal/urinary system physiology 0.0607007263024421 0.197634890938907 1.28401781296388 0.714285714285714 18.2 18 2 decreased tidal volume 0.0607007263024421 0.197634890938907 1.28401781296388 0.714285714285714 18.2 18 2 abnormal uterus physiology 0.0607007263024421 0.197634890938907 1.28401781296388 0.714285714285714 18.2 18 2 heart hemorrhage 0.0607007263024421 0.197634890938907 1.28401781296388 0.714285714285714 18.2 18 2 abnormal sperm annulus morphology 0.0607007263024421 0.197634890938907 1.28401781296388 0.714285714285714 18.2 18 2 increased oligodendrocyte number 0.0607007263024421 0.197634890938907 1.28401781296388 0.714285714285714 18.2 18 2 heart block 0.0607007263024421 0.197634890938907 1.28401781296388 0.714285714285714 18.2 18 2 abnormal conotruncal ridge morphology 0.0607007263024421 0.197634890938907 1.28401781296388 0.714285714285714 18.2 18 2 small lung lobe 0.0607007263024421 0.197634890938907 1.28401781296388 0.714285714285714 18.2 18 2 abnormal outer hair cell kinocilium morphology 0.0607007263024421 0.197634890938907 1.28401781296388 0.714285714285714 18.2 18 2 embryonic lethality at implantation, incomplete penetrance 0.0607007263024421 0.197634890938907 1.28401781296388 0.714285714285714 18.2 18 2 increased circulating lactate dehydrogenase level 0.0607007263024421 0.197634890938907 1.28401781296388 0.714285714285714 18.2 18 2 parturition failure 0.0607007263024421 0.197634890938907 1.28401781296388 0.714285714285714 18.2 18 2 absent heart tube 0.0607007263024421 0.197634890938907 1.28401781296388 0.714285714285714 18.2 18 2 decreased areal bone mineral density 0.0607007263024421 0.197634890938907 1.28401781296388 0.714285714285714 18.2 18 2 abnormal neural tube closure 5.94640737534965e-11 3.11403965182784e-09 1.27782977531104 0.710843373493976 18.2 18 2 lethality throughout fetal growth and development, complete penetrance 3.58963751417846e-23 8.92922331651893e-21 1.2772598244746 0.710526315789474 18.2 18 2 decreased neuron apoptosis 1.00582207657175e-05 0.000173147572004999 1.2772598244746 0.710526315789474 18.2 18 2 decreased total retina thickness 1.00582207657175e-05 0.000173147572004999 1.2772598244746 0.710526315789474 18.2 18 2 abnormal neural tube morphology 6.62281986643066e-20 1.37285536814552e-17 1.27609177708139 0.709876543209877 18.2 18 2 abnormal mitochondrial ATP synthesis coupled electron transport 7.00285258485171e-05 0.000924088680253517 1.27573382707379 0.709677419354839 18.2 18 2 abnormal embryo turning 1.17892129152312e-07 3.27661085213827e-06 1.27467950159687 0.709090909090909 18.2 18 2 abnormal foregut morphology 0.000498564245586042 0.00483500413604398 1.27331766452251 0.708333333333333 18.2 18 2 hypopigmentation 0.000498564245586042 0.00483500413604398 1.27331766452251 0.708333333333333 18.2 18 2 abnormal embryonic tissue morphology 5.68678661194401e-18 8.8411760607567e-16 1.27178907188803 0.707482993197279 18.2 18 2 decreased mean corpuscular hemoglobin 5.25660646226715e-09 1.93715682590956e-07 1.26891172104666 0.705882352941177 18.2 18 2 abnormal gastrulation 4.33600347842738e-07 1.06264124656041e-05 1.26891172104666 0.705882352941177 18.2 18 2 abnormal trophoblast layer morphology 4.33600347842738e-07 1.06264124656041e-05 1.26891172104666 0.705882352941177 18.2 18 2 failure of chorioallantoic fusion 4.33600347842738e-07 1.06264124656041e-05 1.26891172104666 0.705882352941177 18.2 18 2 abnormal brown adipose tissue morphology 3.75897028854647e-05 0.000532788523803951 1.26891172104666 0.705882352941177 18.2 18 2 abnormal nervous system development 3.75897028854647e-05 0.000532788523803951 1.26891172104666 0.705882352941177 18.2 18 2 abnormal direction of heart looping 3.75897028854647e-05 0.000532788523803951 1.26891172104666 0.705882352941177 18.2 18 2 abnormal adipose tissue morphology 0.00368407499835711 0.0255624450722826 1.26891172104666 0.705882352941177 18.2 18 2 hydroureter 0.00368407499835711 0.0255624450722826 1.26891172104666 0.705882352941177 18.2 18 2 abnormal vagus nerve morphology 0.00368407499835711 0.0255624450722826 1.26891172104666 0.705882352941177 18.2 18 2 increased incidence of corneal inflammation 0.00368407499835711 0.0255624450722826 1.26891172104666 0.705882352941177 18.2 18 2 abnormal embryonic-extraembryonic boundary morphology 0.00368407499835711 0.0255624450722826 1.26891172104666 0.705882352941177 18.2 18 2 abnormal ectoplacental cone morphology 0.00368407499835711 0.0255624450722826 1.26891172104666 0.705882352941177 18.2 18 2 enhanced behavioral response to cocaine 0.00368407499835711 0.0255624450722826 1.26891172104666 0.705882352941177 18.2 18 2 increased hepatoma incidence 0.00368407499835711 0.0255624450722826 1.26891172104666 0.705882352941177 18.2 18 2 abnormal fetal cardiomyocyte proliferation 0.000264491597909267 0.00284083947626706 1.2649953268459 0.703703703703704 18.2 18 2 decreased circulating fructosamine level 0.000264491597909267 0.00284083947626706 1.2649953268459 0.703703703703704 18.2 18 2 increased grip strength 1.96980079238894e-11 1.16663796930178e-09 1.26426369276443 0.703296703296703 18.2 18 2 abnormal branching of the mammary ductal tree 2.02064514119608e-05 0.000312195949610264 1.26319590248338 0.702702702702703 18.2 18 2 increased erythroid progenitor cell number 2.02064514119608e-05 0.000312195949610264 1.26319590248338 0.702702702702703 18.2 18 2 abnormal respiratory electron transport chain 2.02064514119608e-05 0.000312195949610264 1.26319590248338 0.702702702702703 18.2 18 2 pulmonary hypoplasia 1.59452233258814e-06 3.39006350625042e-05 1.26216219061556 0.702127659574468 18.2 18 2 increased cellular sensitivity to gamma-irradiation 1.59452233258814e-06 3.39006350625042e-05 1.26216219061556 0.702127659574468 18.2 18 2 neuron degeneration 1.59452233258814e-06 3.39006350625042e-05 1.26216219061556 0.702127659574468 18.2 18 2 embryonic lethality between somite formation and embryo turning, complete penetrance 5.70958913699768e-09 2.08861808504143e-07 1.2583374567046 0.7 18.2 18 2 abnormal pericardium morphology 0.00191537107344736 0.0149508397693283 1.2583374567046 0.7 18.2 18 2 increased urine glucose level 0.00191537107344736 0.0149508397693283 1.2583374567046 0.7 18.2 18 2 abnormal postnatal subventricular zone morphology 0.00191537107344736 0.0149508397693283 1.2583374567046 0.7 18.2 18 2 abnormal incus morphology 0.00191537107344736 0.0149508397693283 1.2583374567046 0.7 18.2 18 2 enlarged testis 0.0293130105056926 0.119632672080247 1.2583374567046 0.7 18.2 18 2 fused cornea and lens 0.0293130105056926 0.119632672080247 1.2583374567046 0.7 18.2 18 2 absent trophoblast giant cells 0.0293130105056926 0.119632672080247 1.2583374567046 0.7 18.2 18 2 abnormal neuron specification 0.0293130105056926 0.119632672080247 1.2583374567046 0.7 18.2 18 2 abnormal primordial germ cell migration 0.0293130105056926 0.119632672080247 1.2583374567046 0.7 18.2 18 2 aneurysm 0.0293130105056926 0.119632672080247 1.2583374567046 0.7 18.2 18 2 absent seminal vesicle 0.0293130105056926 0.119632672080247 1.2583374567046 0.7 18.2 18 2 increased heart rate variability 0.0293130105056926 0.119632672080247 1.2583374567046 0.7 18.2 18 2 abnormal gonadal fat pad morphology 0.0293130105056926 0.119632672080247 1.2583374567046 0.7 18.2 18 2 abnormal retinal blood vessel pattern 0.0293130105056926 0.119632672080247 1.2583374567046 0.7 18.2 18 2 acanthocytosis 0.0293130105056926 0.119632672080247 1.2583374567046 0.7 18.2 18 2 abnormal vibrissa follicle morphology 0.0293130105056926 0.119632672080247 1.2583374567046 0.7 18.2 18 2 aorta stenosis 0.0293130105056926 0.119632672080247 1.2583374567046 0.7 18.2 18 2 abnormal left subclavian artery morphology 0.0293130105056926 0.119632672080247 1.2583374567046 0.7 18.2 18 2 abnormal pulmonary interalveolar septum morphology 0.0293130105056926 0.119632672080247 1.2583374567046 0.7 18.2 18 2 lethality during fetal growth through weaning, complete penetrance 0.0293130105056926 0.119632672080247 1.2583374567046 0.7 18.2 18 2 increased fatty acid oxidation 0.0293130105056926 0.119632672080247 1.2583374567046 0.7 18.2 18 2 abnormal craniofacial morphology 1.78263628606746e-12 1.34372962472509e-10 1.25659218977436 0.699029126213592 18.2 18 2 hypoglycemia 2.13784122378755e-11 1.23671628934222e-09 1.25640452666358 0.698924731182796 18.2 18 2 prenatal lethality, complete penetrance 5.5251270048018e-31 2.29062557074075e-28 1.25445769065104 0.697841726618705 18.2 18 2 kidney failure 5.86163677013592e-06 0.000107211922542008 1.25415693359263 0.697674418604651 18.2 18 2 enlarged pericardium 7.51126493719222e-05 0.000978234111584589 1.25289010840718 0.696969696969697 18.2 18 2 belly spot 7.51126493719222e-05 0.000978234111584589 1.25289010840718 0.696969696969697 18.2 18 2 embryonic lethality between implantation and placentation, complete penetrance 3.1625109778576e-06 6.2683235517297e-05 1.25052169610395 0.695652173913043 18.2 18 2 abnormal Wolffian duct morphology 0.00100295345447288 0.00884697417730951 1.25052169610395 0.695652173913043 18.2 18 2 abnormal hematopoietic stem cell physiology 0.00100295345447288 0.00884697417730951 1.25052169610395 0.695652173913043 18.2 18 2 abnormal vertebral artery topology 0.00100295345447288 0.00884697417730951 1.25052169610395 0.695652173913043 18.2 18 2 abnormal developmental patterning 5.06967536481987e-10 2.33533656851656e-08 1.24956855456729 0.695121951219512 18.2 18 2 increased circulating LDL cholesterol level 1.70799490642539e-06 3.6009946055942e-05 1.24733158973634 0.693877551020408 18.2 18 2 abnormal cell morphology 3.15382703714587e-13 2.75268237014047e-11 1.24572254485794 0.692982456140351 18.2 18 2 kinked neural tube 9.2330212143806e-07 2.10707708906163e-05 1.24450957256499 0.692307692307692 18.2 18 2 abnormal nasal bone morphology 0.000528141711915933 0.00506935463801655 1.24450957256499 0.692307692307692 18.2 18 2 ventricular hypoplasia 0.000528141711915933 0.00506935463801655 1.24450957256499 0.692307692307692 18.2 18 2 decreased circulating glycerol level 0.000528141711915933 0.00506935463801655 1.24450957256499 0.692307692307692 18.2 18 2 abnormal erythrocyte osmotic lysis 0.000528141711915933 0.00506935463801655 1.24450957256499 0.692307692307692 18.2 18 2 absent teeth 0.0146074884463972 0.072043115740879 1.24450957256499 0.692307692307692 18.2 18 2 uterus hypoplasia 0.0146074884463972 0.072043115740879 1.24450957256499 0.692307692307692 18.2 18 2 muscle fatigue 0.0146074884463972 0.072043115740879 1.24450957256499 0.692307692307692 18.2 18 2 increased circulating thyroxine level 0.0146074884463972 0.072043115740879 1.24450957256499 0.692307692307692 18.2 18 2 pericardial edema 2.21094467322829e-08 7.28843423770041e-07 1.24247606019152 0.691176470588235 18.2 18 2 decreased circulating total protein level 4.99538355620044e-07 1.21823692118124e-05 1.24199541181233 0.690909090909091 18.2 18 2 perinatal lethality, complete penetrance 4.5377245545101e-23 1.07500855517561e-20 1.24061439393411 0.690140845070423 18.2 18 2 lordosis 0.000279377246884296 0.00295095924256767 1.23974133665478 0.689655172413793 18.2 18 2 abnormal myocardial trabeculae morphology 6.21776237240097e-06 0.000112484973827981 1.23836384628072 0.688888888888889 18.2 18 2 increased bone mineral content 2.19197076874362e-12 1.62762008574619e-10 1.23689789322209 0.688073394495413 18.2 18 2 decreased hemoglobin content 1.38973714688778e-15 1.64617673946826e-13 1.23666396454252 0.687943262411348 18.2 18 2 embryonic lethality during organogenesis, complete penetrance 1.37774550693737e-57 1.37085677940269e-54 1.23586714497773 0.6875 18.2 18 2 decreased caudal vertebrae number 7.94602403224536e-08 2.32538056237769e-06 1.23586714497773 0.6875 18.2 18 2 increased sacral vertebrae number 7.94602403224536e-08 2.32538056237769e-06 1.23586714497773 0.6875 18.2 18 2 abnormal olfaction 0.00742111602765766 0.0420721467811428 1.23586714497773 0.6875 18.2 18 2 abnormal amnion morphology 0.00742111602765766 0.0420721467811428 1.23586714497773 0.6875 18.2 18 2 abnormal dendritic spine morphology 1.8055024384055e-06 3.75831574521647e-05 1.23366417323981 0.686274509803922 18.2 18 2 increased oxygen consumption 5.74019420105607e-10 2.61995102295908e-08 1.23325431803275 0.686046511627907 18.2 18 2 abnormal artery morphology 7.90091817477474e-05 0.00101831782174882 1.23265710044532 0.685714285714286 18.2 18 2 abnormal embryonic epiblast morphology 7.90091817477474e-05 0.00101831782174882 1.23265710044532 0.685714285714286 18.2 18 2 abnormal long bone epiphyseal plate proliferative zone 9.74621166335055e-07 2.21403666781594e-05 1.23170597613942 0.685185185185185 18.2 18 2 decreased birth body size 1.26657757848217e-12 1.00019419888076e-10 1.22995390504961 0.684210526315789 18.2 18 2 abnormal triglyceride level 0.0038199783976988 0.025866733393155 1.22995390504961 0.684210526315789 18.2 18 2 abnormal stationary movement 0.0038199783976988 0.025866733393155 1.22995390504961 0.684210526315789 18.2 18 2 increased malignant tumor incidence 0.0038199783976988 0.025866733393155 1.22995390504961 0.684210526315789 18.2 18 2 decreased germ cell number 0.0038199783976988 0.025866733393155 1.22995390504961 0.684210526315789 18.2 18 2 abnormal nasal septum morphology 0.0038199783976988 0.025866733393155 1.22995390504961 0.684210526315789 18.2 18 2 abnormal photoreceptor inner segment morphology 0.0038199783976988 0.025866733393155 1.22995390504961 0.684210526315789 18.2 18 2 abnormal blastocyst morphology 0.0038199783976988 0.025866733393155 1.22995390504961 0.684210526315789 18.2 18 2 decreased liver regeneration 0.0038199783976988 0.025866733393155 1.22995390504961 0.684210526315789 18.2 18 2 increased liver cholesterol level 0.0038199783976988 0.025866733393155 1.22995390504961 0.684210526315789 18.2 18 2 thin interventricular septum 0.0038199783976988 0.025866733393155 1.22995390504961 0.684210526315789 18.2 18 2 abnormal somite development 3.7531625107558e-09 1.44744058069846e-07 1.22875628683632 0.683544303797468 18.2 18 2 absent mesoderm 2.84824382203968e-07 7.34197565525771e-06 1.22837704106878 0.683333333333333 18.2 18 2 double outlet right ventricle 8.20606425623914e-12 5.30197008763503e-10 1.22641701387765 0.682242990654206 18.2 18 2 muscular atrophy 1.21127776609586e-05 0.00020396270206754 1.22565336692007 0.681818181818182 18.2 18 2 abnormal enterocyte morphology 0.00198513198827996 0.0151938948333735 1.22565336692007 0.681818181818182 18.2 18 2 abnormal tail movements 0.00198513198827996 0.0151938948333735 1.22565336692007 0.681818181818182 18.2 18 2 intracerebral hemorrhage 0.00198513198827996 0.0151938948333735 1.22565336692007 0.681818181818182 18.2 18 2 abnormal chorion morphology 0.00198513198827996 0.0151938948333735 1.22565336692007 0.681818181818182 18.2 18 2 decreased cardiac output 0.00198513198827996 0.0151938948333735 1.22565336692007 0.681818181818182 18.2 18 2 abnormal circulating lipid level 0.00198513198827996 0.0151938948333735 1.22565336692007 0.681818181818182 18.2 18 2 embryonic lethality between implantation and somite formation, complete penetrance 4.58706965613601e-25 1.52137810261844e-22 1.22531985579982 0.681632653061224 18.2 18 2 embryonic lethality before implantation, complete penetrance 2.1659707234274e-13 1.95921897255478e-11 1.22238495794161 0.68 18.2 18 2 spontaneous skin ulceration 0.0010391087871453 0.00903770317490889 1.22238495794161 0.68 18.2 18 2 increased neuron apoptosis 3.93037135964176e-09 1.50412288570906e-07 1.22060952590393 0.679012345679012 18.2 18 2 abnormal somite shape 0.00054701886407377 0.00520347772230785 1.21981692231569 0.678571428571429 18.2 18 2 absent corpus callosum 0.00054701886407377 0.00520347772230785 1.21981692231569 0.678571428571429 18.2 18 2 preweaning lethality, complete penetrance 7.3510227910161e-72 3.65713383853051e-68 1.21946989047434 0.678378378378378 18.2 18 2 increased tumor incidence 4.15052623865984e-13 3.56014966160909e-11 1.21774592584316 0.67741935483871 18.2 18 2 increased lung adenoma incidence 0.000289290868579369 0.00302994120248918 1.21774592584316 0.67741935483871 18.2 18 2 abnormal capillary morphology 0.000289290868579369 0.00302994120248918 1.21774592584316 0.67741935483871 18.2 18 2 embryonic lethality, complete penetrance 2.35603297292114e-31 1.06556945820751e-28 1.21720058507924 0.677115987460815 18.2 18 2 abnormal extraembryonic tissue morphology 5.5455353441085e-11 2.93500407839785e-09 1.21604039933638 0.676470588235294 18.2 18 2 abnormal eye morphology 2.0090974343933e-14 2.08234577835556e-12 1.21566003011544 0.676258992805755 18.2 18 2 abnormal chromosome morphology 8.17800155088696e-05 0.00104203394277594 1.21461144469556 0.675675675675676 18.2 18 2 abnormal double-strand DNA break repair 2.33696887269819e-05 0.000357736004359185 1.21235170247287 0.674418604651163 18.2 18 2 anophthalmia 1.20717099499905e-09 5.08955567806803e-08 1.2118819807749 0.674157303370786 18.2 18 2 abnormal muscle physiology 1.20717099499905e-09 5.08955567806803e-08 1.2118819807749 0.674157303370786 18.2 18 2 decreased rib number 1.20717099499905e-09 5.08955567806803e-08 1.2118819807749 0.674157303370786 18.2 18 2 abnormal placenta vasculature 3.62179720863258e-06 7.09387445391617e-05 1.20993986221596 0.673076923076923 18.2 18 2 abnormal fertility/fecundity 4.87363368508689e-08 1.46947439898832e-06 1.20662495848386 0.671232876712329 18.2 18 2 astrocytosis 4.87363368508689e-08 1.46947439898832e-06 1.20662495848386 0.671232876712329 18.2 18 2 abnormal axial skeleton morphology 2.64217999999023e-08 8.37251305729389e-07 1.20630094533712 0.671052631578947 18.2 18 2 abnormal brain morphology 5.72345646070656e-16 7.90949885889309e-14 1.20586020695738 0.670807453416149 18.2 18 2 abnormal liver physiology 2.00721099864494e-10 9.69502399830931e-09 1.20440870856012 0.67 18.2 18 2 embryonic lethality during organogenesis, incomplete penetrance 5.16389450091056e-22 1.11697283226218e-19 1.20362713250005 0.669565217391304 18.2 18 2 decreased erythrocyte cell number 1.98257722354757e-15 2.29379574119748e-13 1.20223323888975 0.668789808917197 18.2 18 2 increased circulating alkaline phosphatase level 1.11343688080626e-15 1.35106060536857e-13 1.19841662543295 0.666666666666667 18.2 18 2 abnormal hepatocyte morphology 3.33026406882873e-11 1.8206663453212e-09 1.19841662543295 0.666666666666667 18.2 18 2 thin ventricular wall 2.35817714528749e-09 9.46123491758489e-08 1.19841662543295 0.666666666666667 18.2 18 2 oxidative stress 2.35817714528749e-09 9.46123491758489e-08 1.19841662543295 0.666666666666667 18.2 18 2 abnormal sternum morphology 1.70507976820722e-07 4.6608636521049e-06 1.19841662543295 0.666666666666667 18.2 18 2 perimembraneous ventricular septal defect 1.70507976820722e-07 4.6608636521049e-06 1.19841662543295 0.666666666666667 18.2 18 2 abnormal facial morphology 1.99976647723543e-06 4.12814864076608e-05 1.19841662543295 0.666666666666667 18.2 18 2 abnormal chondrocyte morphology 3.71044061105498e-06 7.15482249612346e-05 1.19841662543295 0.666666666666667 18.2 18 2 abnormal apoptosis 3.71044061105498e-06 7.15482249612346e-05 1.19841662543295 0.666666666666667 18.2 18 2 neurodegeneration 3.71044061105498e-06 7.15482249612346e-05 1.19841662543295 0.666666666666667 18.2 18 2 abnormal cell adhesion 3.71044061105498e-06 7.15482249612346e-05 1.19841662543295 0.666666666666667 18.2 18 2 small heart 1.28257372154752e-05 0.000213404824906318 1.19841662543295 0.666666666666667 18.2 18 2 abnormal pharyngeal arch morphology 0.00015667503327538 0.00178365741543482 1.19841662543295 0.666666666666667 18.2 18 2 abnormal retinal blood vessel morphology 0.00015667503327538 0.00178365741543482 1.19841662543295 0.666666666666667 18.2 18 2 decreased brown adipose tissue amount 0.000294791148782849 0.00303912250907763 1.19841662543295 0.666666666666667 18.2 18 2 thin epidermis 0.00105544193992926 0.00908529625475865 1.19841662543295 0.666666666666667 18.2 18 2 abnormal eye muscle morphology 0.00105544193992926 0.00908529625475865 1.19841662543295 0.666666666666667 18.2 18 2 thick interventricular septum 0.00105544193992926 0.00908529625475865 1.19841662543295 0.666666666666667 18.2 18 2 abnormal nursing 0.00201173187224657 0.0152799481899644 1.19841662543295 0.666666666666667 18.2 18 2 increased hemangiosarcoma incidence 0.00201173187224657 0.0152799481899644 1.19841662543295 0.666666666666667 18.2 18 2 left pulmonary isomerism 0.0038595587393492 0.0259126919409747 1.19841662543295 0.666666666666667 18.2 18 2 abnormal erythrocyte physiology 0.0038595587393492 0.0259126919409747 1.19841662543295 0.666666666666667 18.2 18 2 abnormal embryonic/fetal subventricular zone morphology 0.0038595587393492 0.0259126919409747 1.19841662543295 0.666666666666667 18.2 18 2 abnormal stapes morphology 0.0038595587393492 0.0259126919409747 1.19841662543295 0.666666666666667 18.2 18 2 embryonic lethality at implantation, complete penetrance 0.0038595587393492 0.0259126919409747 1.19841662543295 0.666666666666667 18.2 18 2 delayed kidney development 0.00746727750909529 0.0420721467811428 1.19841662543295 0.666666666666667 18.2 18 2 absent spleen 0.00746727750909529 0.0420721467811428 1.19841662543295 0.666666666666667 18.2 18 2 decreased lactate dehydrogenase level 0.00746727750909529 0.0420721467811428 1.19841662543295 0.666666666666667 18.2 18 2 small thoracic cage 0.00746727750909529 0.0420721467811428 1.19841662543295 0.666666666666667 18.2 18 2 increased gastrointestinal tumor incidence 0.00746727750909529 0.0420721467811428 1.19841662543295 0.666666666666667 18.2 18 2 increased effector memory CD8-positive, alpha-beta T cell number 0.00746727750909529 0.0420721467811428 1.19841662543295 0.666666666666667 18.2 18 2 abnormal metanephric mesenchyme morphology 0.00746727750909529 0.0420721467811428 1.19841662543295 0.666666666666667 18.2 18 2 abnormal glossopharyngeal nerve morphology 0.0290496978974173 0.119632672080247 1.19841662543295 0.666666666666667 18.2 18 2 abnormal mating frequency 0.0290496978974173 0.119632672080247 1.19841662543295 0.666666666666667 18.2 18 2 impaired embryo implantation 0.0290496978974173 0.119632672080247 1.19841662543295 0.666666666666667 18.2 18 2 abnormal respiratory function 0.0290496978974173 0.119632672080247 1.19841662543295 0.666666666666667 18.2 18 2 small thyroid gland 0.0290496978974173 0.119632672080247 1.19841662543295 0.666666666666667 18.2 18 2 delayed somite formation 0.0290496978974173 0.119632672080247 1.19841662543295 0.666666666666667 18.2 18 2 decreased left ventricle systolic pressure 0.0290496978974173 0.119632672080247 1.19841662543295 0.666666666666667 18.2 18 2 abnormal defecation 0.0290496978974173 0.119632672080247 1.19841662543295 0.666666666666667 18.2 18 2 abnormal rostral-caudal body axis extension 0.0290496978974173 0.119632672080247 1.19841662543295 0.666666666666667 18.2 18 2 pale placenta 0.0290496978974173 0.119632672080247 1.19841662543295 0.666666666666667 18.2 18 2 decreased cochlear nerve compound action potential 0.0290496978974173 0.119632672080247 1.19841662543295 0.666666666666667 18.2 18 2 abnormal cochlear outer hair cell physiology 0.0290496978974173 0.119632672080247 1.19841662543295 0.666666666666667 18.2 18 2 decreased renal glomerular filtration rate 0.0290496978974173 0.119632672080247 1.19841662543295 0.666666666666667 18.2 18 2 decreased mammary gland epithelial cell proliferation 0.0290496978974173 0.119632672080247 1.19841662543295 0.666666666666667 18.2 18 2 increased skeletal muscle glycogen level 0.0290496978974173 0.119632672080247 1.19841662543295 0.666666666666667 18.2 18 2 abnormal colon goblet cell morphology 0.0290496978974173 0.119632672080247 1.19841662543295 0.666666666666667 18.2 18 2 renal tubular acidosis 0.0591737118373139 0.196390404530111 1.19841662543295 0.666666666666667 18.2 18 2 abnormal urinary bladder urothelium morphology 0.0591737118373139 0.196390404530111 1.19841662543295 0.666666666666667 18.2 18 2 decreased level of surface class I molecules 0.0591737118373139 0.196390404530111 1.19841662543295 0.666666666666667 18.2 18 2 increased pheochromocytoma incidence 0.0591737118373139 0.196390404530111 1.19841662543295 0.666666666666667 18.2 18 2 abnormal germ cell morphology 0.0591737118373139 0.196390404530111 1.19841662543295 0.666666666666667 18.2 18 2 abnormal vomeronasal organ morphology 0.0591737118373139 0.196390404530111 1.19841662543295 0.666666666666667 18.2 18 2 abnormal lens capsule morphology 0.0591737118373139 0.196390404530111 1.19841662543295 0.666666666666667 18.2 18 2 premature neuronal precursor differentiation 0.0591737118373139 0.196390404530111 1.19841662543295 0.666666666666667 18.2 18 2 decreased cellular sensitivity to ionizing radiation 0.0591737118373139 0.196390404530111 1.19841662543295 0.666666666666667 18.2 18 2 short frontal bone 0.0591737118373139 0.196390404530111 1.19841662543295 0.666666666666667 18.2 18 2 decreased cochlear hair cell number 0.0591737118373139 0.196390404530111 1.19841662543295 0.666666666666667 18.2 18 2 abnormal intervertebral disk development 0.0591737118373139 0.196390404530111 1.19841662543295 0.666666666666667 18.2 18 2 abnormal inguinal fat pad morphology 0.0591737118373139 0.196390404530111 1.19841662543295 0.666666666666667 18.2 18 2 decreased susceptibility to atherosclerosis 0.0591737118373139 0.196390404530111 1.19841662543295 0.666666666666667 18.2 18 2 abnormal optic chiasm morphology 0.0591737118373139 0.196390404530111 1.19841662543295 0.666666666666667 18.2 18 2 eye opacity 0.0591737118373139 0.196390404530111 1.19841662543295 0.666666666666667 18.2 18 2 abnormal hyoid bone lesser horn morphology 0.0591737118373139 0.196390404530111 1.19841662543295 0.666666666666667 18.2 18 2 axonal spheroids 0.0591737118373139 0.196390404530111 1.19841662543295 0.666666666666667 18.2 18 2 abnormal telomere morphology 0.0591737118373139 0.196390404530111 1.19841662543295 0.666666666666667 18.2 18 2 abnormal ventricle myocardium morphology 0.0591737118373139 0.196390404530111 1.19841662543295 0.666666666666667 18.2 18 2 iris coloboma 0.0591737118373139 0.196390404530111 1.19841662543295 0.666666666666667 18.2 18 2 abnormal pulmonary alveolar system morphology 0.0591737118373139 0.196390404530111 1.19841662543295 0.666666666666667 18.2 18 2 abnormal lung lobe morphology 0.0591737118373139 0.196390404530111 1.19841662543295 0.666666666666667 18.2 18 2 increased core body temperature 0.0591737118373139 0.196390404530111 1.19841662543295 0.666666666666667 18.2 18 2 decreased pancreatic beta cell proliferation 0.0591737118373139 0.196390404530111 1.19841662543295 0.666666666666667 18.2 18 2 increased myeloid cell number 0.0591737118373139 0.196390404530111 1.19841662543295 0.666666666666667 18.2 18 2 abnormal ductus venosus valve topology 0.0591737118373139 0.196390404530111 1.19841662543295 0.666666666666667 18.2 18 2 abnormal coronary sinus connection 0.0591737118373139 0.196390404530111 1.19841662543295 0.666666666666667 18.2 18 2 symmetric azygos veins 0.0591737118373139 0.196390404530111 1.19841662543295 0.666666666666667 18.2 18 2 increased endoplasmic reticulum stress 0.0591737118373139 0.196390404530111 1.19841662543295 0.666666666666667 18.2 18 2 increased erythrocyte cell number 1.07903807936703e-06 2.40727105150268e-05 1.19841662543295 0.666666666666667 18.2 18 2 absent incisors 0.0146113575442305 0.072043115740879 1.19841662543295 0.666666666666667 18.2 18 2 macrocytosis 0.0146113575442305 0.072043115740879 1.19841662543295 0.666666666666667 18.2 18 2 decreased hepatocyte number 0.0146113575442305 0.072043115740879 1.19841662543295 0.666666666666667 18.2 18 2 audiogenic seizures 0.0146113575442305 0.072043115740879 1.19841662543295 0.666666666666667 18.2 18 2 abnormal lymph node B cell domain morphology 0.0146113575442305 0.072043115740879 1.19841662543295 0.666666666666667 18.2 18 2 abnormal placenta size 0.0146113575442305 0.072043115740879 1.19841662543295 0.666666666666667 18.2 18 2 abnormal cerebral aqueduct morphology 0.0146113575442305 0.072043115740879 1.19841662543295 0.666666666666667 18.2 18 2 liver vascular congestion 0.0146113575442305 0.072043115740879 1.19841662543295 0.666666666666667 18.2 18 2 bicuspid aortic valve 0.0146113575442305 0.072043115740879 1.19841662543295 0.666666666666667 18.2 18 2 herniated liver 0.0146113575442305 0.072043115740879 1.19841662543295 0.666666666666667 18.2 18 2 abnormal branching involved in lung morphogenesis 0.0146113575442305 0.072043115740879 1.19841662543295 0.666666666666667 18.2 18 2 decreased birth weight 1.31055147136042e-09 5.47898619329251e-08 1.19210916950962 0.663157894736842 18.2 18 2 decreased liver weight 1.73789970213377e-07 4.69894077071494e-06 1.18997707173272 0.661971830985915 18.2 18 2 prenatal lethality 1.09780078373856e-06 2.41661898190236e-05 1.18875197522785 0.661290322580645 18.2 18 2 pericardial effusion 1.09780078373856e-06 2.41661898190236e-05 1.18875197522785 0.661290322580645 18.2 18 2 extramedullary hematopoiesis 2.1504768242324e-10 1.0287136731304e-08 1.18711080821189 0.660377358490566 18.2 18 2 atrioventricular septal defect 6.99586765078148e-06 0.00012468003172129 1.18711080821189 0.660377358490566 18.2 18 2 abnormal astrocyte morphology 4.51330501212935e-05 0.000621985940037216 1.1847982546894 0.659090909090909 18.2 18 2 palatal shelves fail to meet at midline 8.43245968265262e-05 0.00106475855129941 1.18380178853743 0.658536585365854 18.2 18 2 abnormal nervous system morphology 5.17810454944198e-08 1.55187169478758e-06 1.18324679473127 0.658227848101266 18.2 18 2 decreased hair follicle number 0.000157906421335887 0.00179357179485396 1.18264798562463 0.657894736842105 18.2 18 2 preweaning lethality, incomplete penetrance 2.48237726863863e-35 1.37220299016413e-32 1.18230099844058 0.657701711491443 18.2 18 2 domed cranium 3.24900068365122e-07 8.24682571488e-06 1.18129638792677 0.657142857142857 18.2 18 2 thick pulmonary interalveolar septum 0.000296477416269761 0.00303912250907763 1.18129638792677 0.657142857142857 18.2 18 2 abnormal midbrain development 0.000296477416269761 0.00303912250907763 1.18129638792677 0.657142857142857 18.2 18 2 holoprosencephaly 0.000296477416269761 0.00303912250907763 1.18129638792677 0.657142857142857 18.2 18 2 abnormal hippocampus pyramidal cell morphology 0.000296477416269761 0.00303912250907763 1.18129638792677 0.657142857142857 18.2 18 2 impaired adaptive thermogenesis 0.000296477416269761 0.00303912250907763 1.18129638792677 0.657142857142857 18.2 18 2 cleft palate 3.1646144368264e-12 2.24913668903019e-10 1.18012018840344 0.656488549618321 18.2 18 2 scoliosis 0.000558381151077541 0.00527124521178514 1.17969136566056 0.65625 18.2 18 2 abnormal embryonic hematopoiesis 0.000558381151077541 0.00527124521178514 1.17969136566056 0.65625 18.2 18 2 increased fatty acid level 0.000558381151077541 0.00527124521178514 1.17969136566056 0.65625 18.2 18 2 decreased trophoblast giant cell number 0.00105553793673377 0.00908529625475865 1.17775426982204 0.655172413793103 18.2 18 2 blood in lymph vessels 0.00105553793673377 0.00908529625475865 1.17775426982204 0.655172413793103 18.2 18 2 abnormal embryo size 1.20164003615674e-10 5.86094037243117e-09 1.17720571170848 0.654867256637168 18.2 18 2 abnormal behavior 5.19529173103297e-24 1.61541102261806e-21 1.17686236957984 0.654676258992806 18.2 18 2 increased heart weight 9.53073867656068e-13 7.66241629275993e-11 1.17686236957984 0.654676258992806 18.2 18 2 ventricular septal defect 1.74558401028722e-12 1.34372962472509e-10 1.17638690805367 0.654411764705882 18.2 18 2 liver hypoplasia 1.30732125259058e-05 0.000213944843145992 1.17537015186694 0.653846153846154 18.2 18 2 abnormal ureter morphology 0.00200426881813411 0.0152698887752178 1.17537015186694 0.653846153846154 18.2 18 2 abnormal ocular fundus morphology 0.00200426881813411 0.0152698887752178 1.17537015186694 0.653846153846154 18.2 18 2 abnormal nerve conduction 0.00200426881813411 0.0152698887752178 1.17537015186694 0.653846153846154 18.2 18 2 abnormal long bone hypertrophic chondrocyte zone 2.42964445905324e-05 0.000364080758547888 1.17395914328126 0.653061224489796 18.2 18 2 abnormal craniofacial development 2.42964445905324e-05 0.000364080758547888 1.17395914328126 0.653061224489796 18.2 18 2 decreased circulating creatinine level 2.42964445905324e-05 0.000364080758547888 1.17395914328126 0.653061224489796 18.2 18 2 decreased spleen weight 6.03166221935839e-07 1.44963862518396e-05 1.17236409009746 0.652173913043478 18.2 18 2 abnormal pulmonary artery morphology 0.00382671673916825 0.025866733393155 1.17236409009745 0.652173913043478 18.2 18 2 abnormal nasal cavity morphology 0.00382671673916825 0.025866733393155 1.17236409009745 0.652173913043478 18.2 18 2 abnormal chondrocyte physiology 0.00382671673916825 0.025866733393155 1.17236409009745 0.652173913043478 18.2 18 2 increased circulating creatinine level 2.85218532722832e-08 8.92429056789993e-07 1.17054647135312 0.651162790697674 18.2 18 2 decreased susceptibility to hepatic steatosis 2.05750911451142e-06 4.19512616585833e-05 1.16988289625598 0.650793650793651 18.2 18 2 decreased circulating cholesterol level 6.96194924651316e-16 9.36099932470351e-14 1.16894736415182 0.650273224043716 18.2 18 2 abnormal basioccipital bone morphology 0.00735710628559431 0.0418782651840179 1.16845620979713 0.65 18.2 18 2 abnormal vascular regression 0.00735710628559431 0.0418782651840179 1.16845620979713 0.65 18.2 18 2 small gonad 0.00735710628559431 0.0418782651840179 1.16845620979713 0.65 18.2 18 2 absent placental labyrinth 0.00735710628559431 0.0418782651840179 1.16845620979713 0.65 18.2 18 2 abnormal physiological neovascularization 0.00735710628559431 0.0418782651840179 1.16845620979713 0.65 18.2 18 2 abnormal optic stalk morphology 0.00735710628559431 0.0418782651840179 1.16845620979713 0.65 18.2 18 2 kidney atrophy 0.00735710628559431 0.0418782651840179 1.16845620979713 0.65 18.2 18 2 abnormal sperm mitochondrial sheath morphology 0.00735710628559431 0.0418782651840179 1.16845620979713 0.65 18.2 18 2 decreased leukocyte cell number 3.2345682445456e-12 2.26647563614287e-10 1.16780014230146 0.64963503649635 18.2 18 2 incomplete embryo turning 7.04222892737336e-06 0.00012468003172129 1.1668793458163 0.649122807017544 18.2 18 2 abnormal craniofacial bone morphology 7.04222892737336e-06 0.00012468003172129 1.1668793458163 0.649122807017544 18.2 18 2 abnormal circulating amino acid level 7.04222892737336e-06 0.00012468003172129 1.1668793458163 0.649122807017544 18.2 18 2 decreased width of hypertrophic chondrocyte zone 0.000294942758382785 0.00303912250907763 1.16602698690774 0.648648648648649 18.2 18 2 abnormal axon morphology 7.47626800075154e-10 3.32093154497669e-08 1.16512727472648 0.648148148148148 18.2 18 2 increased cell proliferation 1.3047970092383e-05 0.000213944843145992 1.16512727472648 0.648148148148148 18.2 18 2 abnormal small intestine morphology 1.3047970092383e-05 0.000213944843145992 1.16512727472648 0.648148148148148 18.2 18 2 decreased platelet aggregation 1.3047970092383e-05 0.000213944843145992 1.16512727472648 0.648148148148148 18.2 18 2 increased width of hypertrophic chondrocyte zone 0.000553697102838127 0.00525695245538108 1.1631690776261 0.647058823529412 18.2 18 2 abnormal bone marrow cavity morphology 0.0142723579147087 0.071433582118386 1.1631690776261 0.647058823529412 18.2 18 2 abnormal interatrial septum morphology 0.0142723579147087 0.071433582118386 1.1631690776261 0.647058823529412 18.2 18 2 hyperlipidemia 0.0142723579147087 0.071433582118386 1.1631690776261 0.647058823529412 18.2 18 2 pancytopenia 0.0142723579147087 0.071433582118386 1.1631690776261 0.647058823529412 18.2 18 2 increased circulating magnesium level 0.0142723579147087 0.071433582118386 1.1631690776261 0.647058823529412 18.2 18 2 delayed heart development 0.0142723579147087 0.071433582118386 1.1631690776261 0.647058823529412 18.2 18 2 abnormal ductus venosus valve morphology 0.0142723579147087 0.071433582118386 1.1631690776261 0.647058823529412 18.2 18 2 cardiac fibrosis 5.24293437388036e-08 1.56189212635059e-06 1.1631690776261 0.647058823529412 18.2 18 2 abnormal cervical vertebrae morphology 2.42032401813631e-05 0.000364080758547888 1.1631690776261 0.647058823529412 18.2 18 2 decreased total body fat amount 3.85718463092286e-27 1.47611488760317e-24 1.16253588814454 0.646706586826347 18.2 18 2 embryonic growth arrest 5.07597640658717e-19 9.35295652695228e-17 1.16178380282147 0.646288209606987 18.2 18 2 overriding aortic valve 4.49532017080297e-05 0.000621228273604021 1.16096610588817 0.645833333333333 18.2 18 2 pallor 7.78427577420867e-15 8.60594932815291e-13 1.16075210291935 0.645714285714286 18.2 18 2 abnormal vitelline vasculature morphology 4.05991853230319e-10 1.90548063190645e-08 1.15673256889616 0.643478260869565 18.2 18 2 hydronephrosis 9.57920170560673e-08 2.73888094743641e-06 1.15561603166749 0.642857142857143 18.2 18 2 abnormal eye development 1.29382799596125e-05 0.000213944843145992 1.15561603166749 0.642857142857143 18.2 18 2 abnormal optic nerve morphology 0.000155772950257913 0.0017815412127198 1.15561603166749 0.642857142857143 18.2 18 2 rib bifurcation 0.00197060347646917 0.0151938948333735 1.15561603166749 0.642857142857143 18.2 18 2 failure of blastocyst to hatch from the zona pellucida 0.00197060347646917 0.0151938948333735 1.15561603166749 0.642857142857143 18.2 18 2 abnormal hormone level 0.00197060347646917 0.0151938948333735 1.15561603166749 0.642857142857143 18.2 18 2 abnormal renal tubule epithelium morphology 0.00197060347646917 0.0151938948333735 1.15561603166749 0.642857142857143 18.2 18 2 abnormal blood flow velocity 0.0280257835344631 0.118377301615527 1.15561603166749 0.642857142857143 18.2 18 2 increased aggression towards males 0.0280257835344631 0.118377301615527 1.15561603166749 0.642857142857143 18.2 18 2 abnormal pinna reflex 0.0280257835344631 0.118377301615527 1.15561603166749 0.642857142857143 18.2 18 2 absent otoliths 0.0280257835344631 0.118377301615527 1.15561603166749 0.642857142857143 18.2 18 2 vascular smooth muscle hypoplasia 0.0280257835344631 0.118377301615527 1.15561603166749 0.642857142857143 18.2 18 2 sternebra fusion 0.0280257835344631 0.118377301615527 1.15561603166749 0.642857142857143 18.2 18 2 increased stomach tumor incidence 0.0280257835344631 0.118377301615527 1.15561603166749 0.642857142857143 18.2 18 2 rib fusion 2.0336466790761e-06 4.16353589646238e-05 1.15369958717053 0.641791044776119 18.2 18 2 abnormal mesoderm development 2.39484612498125e-05 0.000364080758547888 1.15319335654869 0.641509433962264 18.2 18 2 abnormal locomotor behavior 2.82215509507032e-08 8.88621620124989e-07 1.15282468859583 0.641304347826087 18.2 18 2 failure of heart looping 0.000290746200376069 0.00303241582153237 1.15232367830092 0.641025641025641 18.2 18 2 microphthalmia 9.54914191258524e-13 7.66241629275993e-11 1.15141989502382 0.640522875816993 18.2 18 2 ruffled hair 0.00374083957909325 0.025776560811619 1.15047996041564 0.64 18.2 18 2 mandible hypoplasia 0.00374083957909325 0.025776560811619 1.15047996041564 0.64 18.2 18 2 abnormal egg cylinder morphology 0.00374083957909325 0.025776560811619 1.15047996041564 0.64 18.2 18 2 abnormal keratinocyte physiology 0.00374083957909325 0.025776560811619 1.15047996041564 0.64 18.2 18 2 increased cellular sensitivity to ionizing radiation 0.00374083957909325 0.025776560811619 1.15047996041564 0.64 18.2 18 2 abnormal neuromuscular synapse morphology 1.09127716610117e-06 2.41661898190236e-05 1.14848259937325 0.638888888888889 18.2 18 2 narrow eye opening 0.000543820093875208 0.00519290780619801 1.14848259937325 0.638888888888889 18.2 18 2 hepatic necrosis 8.23154451278283e-05 0.00104203394277594 1.14742017328687 0.638297872340426 18.2 18 2 increased respiratory quotient 8.23154451278283e-05 0.00104203394277594 1.14742017328687 0.638297872340426 18.2 18 2 prenatal lethality, incomplete penetrance 1.7173692711484e-23 4.49679585471751e-21 1.14716854605589 0.638157894736842 18.2 18 2 thymus hypoplasia 1.92779424839407e-11 1.15551522720006e-09 1.14631155476196 0.63768115942029 18.2 18 2 perinatal lethality, incomplete penetrance 9.87039860453153e-18 1.48803736538013e-15 1.14538934112176 0.63716814159292 18.2 18 2 abnormal neuron morphology 1.50481756208961e-08 5.16670980128187e-07 1.14394314245873 0.636363636363636 18.2 18 2 decreased circulating serum albumin level 1.50481756208961e-08 5.16670980128187e-07 1.14394314245873 0.636363636363636 18.2 18 2 polyuria 5.85264989673434e-07 1.41344336098317e-05 1.14394314245873 0.636363636363636 18.2 18 2 osteoporosis 0.000152894339461994 0.00176076235838755 1.14394314245873 0.636363636363636 18.2 18 2 renal interstitial fibrosis 0.000152894339461994 0.00176076235838755 1.14394314245873 0.636363636363636 18.2 18 2 decreased blood urea nitrogen level 0.000152894339461994 0.00176076235838755 1.14394314245873 0.636363636363636 18.2 18 2 increased osteoblast cell number 0.00101966365509324 0.00893829494819973 1.14394314245873 0.636363636363636 18.2 18 2 abnormal abdominal fat pad morphology 0.00713980555372038 0.041378579440801 1.14394314245873 0.636363636363636 18.2 18 2 abnormal facial nerve morphology 0.00713980555372038 0.041378579440801 1.14394314245873 0.636363636363636 18.2 18 2 increased body size 0.00713980555372038 0.041378579440801 1.14394314245873 0.636363636363636 18.2 18 2 increased skin papilloma incidence 0.00713980555372038 0.041378579440801 1.14394314245873 0.636363636363636 18.2 18 2 increased myocardial infarction size 0.00713980555372038 0.041378579440801 1.14394314245873 0.636363636363636 18.2 18 2 abnormal lysosome physiology 0.00713980555372038 0.041378579440801 1.14394314245873 0.636363636363636 18.2 18 2 abnormal vascular branching morphogenesis 0.00713980555372038 0.041378579440801 1.14394314245873 0.636363636363636 18.2 18 2 abnormal cochlear sensory epithelium morphology 0.00713980555372038 0.041378579440801 1.14394314245873 0.636363636363636 18.2 18 2 cleft upper lip 0.00713980555372038 0.041378579440801 1.14394314245873 0.636363636363636 18.2 18 2 abnormal occipital bone morphology 0.00713980555372038 0.041378579440801 1.14394314245873 0.636363636363636 18.2 18 2 increased adenoma incidence 0.00713980555372038 0.041378579440801 1.14394314245873 0.636363636363636 18.2 18 2 absent semicircular canals 0.0559916461826439 0.196390404530111 1.14394314245873 0.636363636363636 18.2 18 2 premature suture closure 0.0559916461826439 0.196390404530111 1.14394314245873 0.636363636363636 18.2 18 2 abnormal sphenoid bone morphology 0.0559916461826439 0.196390404530111 1.14394314245873 0.636363636363636 18.2 18 2 abnormal stomach epithelium morphology 0.0559916461826439 0.196390404530111 1.14394314245873 0.636363636363636 18.2 18 2 abnormal glossopharyngeal ganglion morphology 0.0559916461826439 0.196390404530111 1.14394314245873 0.636363636363636 18.2 18 2 abnormal food preference 0.0559916461826439 0.196390404530111 1.14394314245873 0.636363636363636 18.2 18 2 abnormal hemoglobin 0.0559916461826439 0.196390404530111 1.14394314245873 0.636363636363636 18.2 18 2 impaired myelopoiesis 0.0559916461826439 0.196390404530111 1.14394314245873 0.636363636363636 18.2 18 2 abnormal hypothalamus secretion 0.0559916461826439 0.196390404530111 1.14394314245873 0.636363636363636 18.2 18 2 abnormal bronchiole morphology 0.0559916461826439 0.196390404530111 1.14394314245873 0.636363636363636 18.2 18 2 retinal detachment 0.0559916461826439 0.196390404530111 1.14394314245873 0.636363636363636 18.2 18 2 fused joints 0.0559916461826439 0.196390404530111 1.14394314245873 0.636363636363636 18.2 18 2 loss of cortex neurons 0.0559916461826439 0.196390404530111 1.14394314245873 0.636363636363636 18.2 18 2 abnormal ureter development 0.0559916461826439 0.196390404530111 1.14394314245873 0.636363636363636 18.2 18 2 abnormal palate development 0.0559916461826439 0.196390404530111 1.14394314245873 0.636363636363636 18.2 18 2 abnormal aorta smooth muscle morphology 0.0559916461826439 0.196390404530111 1.14394314245873 0.636363636363636 18.2 18 2 increased number of Howell-Jolly bodies 0.0559916461826439 0.196390404530111 1.14394314245873 0.636363636363636 18.2 18 2 distended pericardium 4.35343408461048e-05 0.000603296227602706 1.14080044151791 0.634615384615385 18.2 18 2 eyelids open at birth 4.35343408461048e-05 0.000603296227602706 1.14080044151791 0.634615384615385 18.2 18 2 increased blood urea nitrogen level 1.02943406820779e-11 6.40179311166718e-10 1.1405620297224 0.63448275862069 18.2 18 2 liver fibrosis 0.000284397700902203 0.00299128660039844 1.13995727785086 0.634146341463415 18.2 18 2 hemorrhage 5.20997267683658e-18 8.36116582814903e-16 1.13977070546496 0.634042553191489 18.2 18 2 edema 1.48633989381597e-13 1.36935943921008e-11 1.1391925480133 0.633720930232558 18.2 18 2 abnormal heart tube morphology 0.0019173137231822 0.0149508397693283 1.13849579416131 0.633333333333333 18.2 18 2 abnormal cellular respiration 0.0019173137231822 0.0149508397693283 1.13849579416131 0.633333333333333 18.2 18 2 abnormal visceral yolk sac morphology 5.74707290118168e-07 1.39471647235995e-05 1.13773730262622 0.632911392405063 18.2 18 2 increased T cell derived lymphoma incidence 8.05287278548304e-05 0.00102989825469867 1.13727292005372 0.63265306122449 18.2 18 2 increased sarcoma incidence 8.05287278548304e-05 0.00102989825469867 1.13727292005372 0.63265306122449 18.2 18 2 decreased urine osmolality 8.05287278548304e-05 0.00102989825469867 1.13727292005372 0.63265306122449 18.2 18 2 abnormal embryo development 6.21048706475799e-11 3.21845553616364e-09 1.13673341677096 0.632352941176471 18.2 18 2 incomplete somite formation 0.000529862193320322 0.00506935463801655 1.13534206619964 0.631578947368421 18.2 18 2 impaired branching involved in ureteric bud morphogenesis 0.000529862193320322 0.00506935463801655 1.13534206619964 0.631578947368421 18.2 18 2 decreased tumor incidence 0.0137197902714893 0.070294497014067 1.13534206619964 0.631578947368421 18.2 18 2 increased left ventricle weight 0.0137197902714893 0.070294497014067 1.13534206619964 0.631578947368421 18.2 18 2 increased circulating VLDL cholesterol level 0.0137197902714893 0.070294497014067 1.13534206619964 0.631578947368421 18.2 18 2 atrial septal defect 0.000149101164129682 0.00174126359517646 1.13328528709421 0.630434782608696 18.2 18 2 abnormal neuronal precursor proliferation 4.24792962174429e-05 0.000591973385663245 1.13183792402001 0.62962962962963 18.2 18 2 abnormal trigeminal ganglion morphology 0.00361727451108235 0.0254179953285801 1.13183792402001 0.62962962962963 18.2 18 2 increased brain weight 0.00361727451108235 0.0254179953285801 1.13183792402001 0.62962962962963 18.2 18 2 cryptorchism 0.00361727451108235 0.0254179953285801 1.13183792402001 0.62962962962963 18.2 18 2 respiratory failure 9.74140596916968e-12 6.15924173410853e-10 1.1309560869152 0.629139072847682 18.2 18 2 ovary cysts 0.000988991957030742 0.00878613390397847 1.12993567540821 0.628571428571429 18.2 18 2 increased carcinoma incidence 0.000988991957030742 0.00878613390397847 1.12993567540821 0.628571428571429 18.2 18 2 increased rib number 1.02822843478179e-06 2.30425065902676e-05 1.1292772047349 0.628205128205128 18.2 18 2 abnormal cornea morphology 1.02822843478179e-06 2.30425065902676e-05 1.1292772047349 0.628205128205128 18.2 18 2 abnormal organ of Corti morphology 0.000276351536006667 0.00292521040773014 1.12874124023336 0.627906976744186 18.2 18 2 abnormal homeostasis 0.000276351536006667 0.00292521040773014 1.12874124023336 0.627906976744186 18.2 18 2 decreased oxygen consumption 0.000276351536006667 0.00292521040773014 1.12874124023336 0.627906976744186 18.2 18 2 thrombocytopenia 3.21187644382596e-11 1.79540284359934e-09 1.12816461635585 0.627586206896552 18.2 18 2 internal hemorrhage 6.47667040914324e-06 0.00011674433074452 1.12686936421308 0.626865671641791 18.2 18 2 kyphosis 1.72871735055709e-11 1.04882546573433e-09 1.12651162790698 0.626666666666667 18.2 18 2 abnormal heart development 5.12989415768214e-12 3.40282979126248e-10 1.12635992959996 0.626582278481013 18.2 18 2 increased mean corpuscular hemoglobin 4.71198631053309e-08 1.43816760091424e-06 1.12578531480065 0.626262626262626 18.2 18 2 infertility 1.38669086767759e-08 4.8927567848908e-07 1.12561561547675 0.626168224299065 18.2 18 2 abnormal retinal pigment epithelium morphology 1.00086262006754e-06 2.26331433401637e-05 1.12351558634339 0.625 18.2 18 2 decreased circulating LDL cholesterol level 1.18702854628636e-05 0.000201374007650727 1.12351558634339 0.625 18.2 18 2 abnormal kidney physiology 0.000144585850827491 0.00169250495968651 1.12351558634339 0.625 18.2 18 2 thymus atrophy 0.000144585850827491 0.00169250495968651 1.12351558634339 0.625 18.2 18 2 perinatal lethality 0.000512786411123878 0.00496325368743442 1.12351558634339 0.625 18.2 18 2 abnormal vertebral body morphology 0.00184978926491368 0.0145612366976987 1.12351558634339 0.625 18.2 18 2 polydipsia 0.00184978926491368 0.0145612366976987 1.12351558634339 0.625 18.2 18 2 neonatal lethality 0.00184978926491368 0.0145612366976987 1.12351558634339 0.625 18.2 18 2 bradykinesia 0.00184978926491368 0.0145612366976987 1.12351558634339 0.625 18.2 18 2 hemolytic anemia 0.00685169151737102 0.0407308725578859 1.12351558634339 0.625 18.2 18 2 decreased fatty acid level 0.00685169151737102 0.0407308725578859 1.12351558634339 0.625 18.2 18 2 abnormal truncus arteriosus septation 0.00685169151737102 0.0407308725578859 1.12351558634339 0.625 18.2 18 2 white spotting 0.0265950934051853 0.115353609146292 1.12351558634339 0.625 18.2 18 2 increased pancreatic beta cell number 0.0265950934051853 0.115353609146292 1.12351558634339 0.625 18.2 18 2 small pancreas 0.0265950934051853 0.115353609146292 1.12351558634339 0.625 18.2 18 2 bowed tibia 0.0265950934051853 0.115353609146292 1.12351558634339 0.625 18.2 18 2 bowed radius 0.0265950934051853 0.115353609146292 1.12351558634339 0.625 18.2 18 2 small epididymis 0.0265950934051853 0.115353609146292 1.12351558634339 0.625 18.2 18 2 increased heart left ventricle size 0.0265950934051853 0.115353609146292 1.12351558634339 0.625 18.2 18 2 abnormal pulmonary alveolus wall morphology 0.0265950934051853 0.115353609146292 1.12351558634339 0.625 18.2 18 2 embryonic lethality between somite formation and embryo turning, incomplete penetrance 0.0265950934051853 0.115353609146292 1.12351558634339 0.625 18.2 18 2 decreased adipocyte glucose uptake 0.0265950934051853 0.115353609146292 1.12351558634339 0.625 18.2 18 2 abnormal exoccipital bone morphology 0.114874599314251 0.316122954191448 1.12351558634339 0.625 18.2 18 2 failure of vascular branching 0.114874599314251 0.316122954191448 1.12351558634339 0.625 18.2 18 2 pointed snout 0.114874599314251 0.316122954191448 1.12351558634339 0.625 18.2 18 2 abnormal esophageal epithelium morphology 0.114874599314251 0.316122954191448 1.12351558634339 0.625 18.2 18 2 abnormal hypoglossal nerve morphology 0.114874599314251 0.316122954191448 1.12351558634339 0.625 18.2 18 2 abnormal vagus ganglion morphology 0.114874599314251 0.316122954191448 1.12351558634339 0.625 18.2 18 2 absent skin pigmentation 0.114874599314251 0.316122954191448 1.12351558634339 0.625 18.2 18 2 dry eyes 0.114874599314251 0.316122954191448 1.12351558634339 0.625 18.2 18 2 poor grooming 0.114874599314251 0.316122954191448 1.12351558634339 0.625 18.2 18 2 abnormal erythrocyte cell number 0.114874599314251 0.316122954191448 1.12351558634339 0.625 18.2 18 2 abnormal atrial thrombosis 0.114874599314251 0.316122954191448 1.12351558634339 0.625 18.2 18 2 preneoplasia 0.114874599314251 0.316122954191448 1.12351558634339 0.625 18.2 18 2 abnormal muscle precursor cell migration 0.114874599314251 0.316122954191448 1.12351558634339 0.625 18.2 18 2 hypospadia 0.114874599314251 0.316122954191448 1.12351558634339 0.625 18.2 18 2 abnormal soft palate morphology 0.114874599314251 0.316122954191448 1.12351558634339 0.625 18.2 18 2 abnormal cellular cholesterol metabolism 0.114874599314251 0.316122954191448 1.12351558634339 0.625 18.2 18 2 abnormal umbilical artery morphology 0.114874599314251 0.316122954191448 1.12351558634339 0.625 18.2 18 2 liver failure 0.114874599314251 0.316122954191448 1.12351558634339 0.625 18.2 18 2 increased cardiac output 0.114874599314251 0.316122954191448 1.12351558634339 0.625 18.2 18 2 abnormal lateral ganglionic eminence morphology 0.114874599314251 0.316122954191448 1.12351558634339 0.625 18.2 18 2 long femur 0.114874599314251 0.316122954191448 1.12351558634339 0.625 18.2 18 2 thin stria vascularis 0.114874599314251 0.316122954191448 1.12351558634339 0.625 18.2 18 2 bowed fibula 0.114874599314251 0.316122954191448 1.12351558634339 0.625 18.2 18 2 non-pigmented tail tip 0.114874599314251 0.316122954191448 1.12351558634339 0.625 18.2 18 2 abnormal epidermal lamellar body morphology 0.114874599314251 0.316122954191448 1.12351558634339 0.625 18.2 18 2 enlarged inguinal lymph nodes 0.114874599314251 0.316122954191448 1.12351558634339 0.625 18.2 18 2 abnormal meiotic spindle morphology 0.114874599314251 0.316122954191448 1.12351558634339 0.625 18.2 18 2 decreased hippocampus pyramidal cell number 0.114874599314251 0.316122954191448 1.12351558634339 0.625 18.2 18 2 abnormal sensory neuron physiology 0.114874599314251 0.316122954191448 1.12351558634339 0.625 18.2 18 2 increased caudal vertebrae number 0.114874599314251 0.316122954191448 1.12351558634339 0.625 18.2 18 2 abnormal lateral plate mesoderm morphology 0.114874599314251 0.316122954191448 1.12351558634339 0.625 18.2 18 2 decreased quadriceps weight 0.114874599314251 0.316122954191448 1.12351558634339 0.625 18.2 18 2 anomalous pulmonary venous connection 0.114874599314251 0.316122954191448 1.12351558634339 0.625 18.2 18 2 increased heart right ventricle size 0.114874599314251 0.316122954191448 1.12351558634339 0.625 18.2 18 2 abnormal visual evoked potential 0.114874599314251 0.316122954191448 1.12351558634339 0.625 18.2 18 2 impaired mucociliary clearance 0.114874599314251 0.316122954191448 1.12351558634339 0.625 18.2 18 2 abnormal stomach position or orientation 0.114874599314251 0.316122954191448 1.12351558634339 0.625 18.2 18 2 abnormal anterior commissure pars posterior morphology 0.114874599314251 0.316122954191448 1.12351558634339 0.625 18.2 18 2 decreased alveolar lamellar body number 0.114874599314251 0.316122954191448 1.12351558634339 0.625 18.2 18 2 abnormal maxillary prominence morphology 0.114874599314251 0.316122954191448 1.12351558634339 0.625 18.2 18 2 abnormal foramen magnum morphology 0.114874599314251 0.316122954191448 1.12351558634339 0.625 18.2 18 2 abnormal bronchus epithelium morphology 0.114874599314251 0.316122954191448 1.12351558634339 0.625 18.2 18 2 lethality during fetal growth through weaning, incomplete penetrance 0.114874599314251 0.316122954191448 1.12351558634339 0.625 18.2 18 2 increased cardiac stroke volume 0.114874599314251 0.316122954191448 1.12351558634339 0.625 18.2 18 2 increased circulating lactate level 0.114874599314251 0.316122954191448 1.12351558634339 0.625 18.2 18 2 increased mammary gland apoptosis 0.114874599314251 0.316122954191448 1.12351558634339 0.625 18.2 18 2 decreased basal metabolism 0.114874599314251 0.316122954191448 1.12351558634339 0.625 18.2 18 2 abnormal definitive hematopoiesis 1.56118511197992e-07 4.31494218450005e-06 1.12109942379212 0.623655913978495 18.2 18 2 postnatal growth retardation 3.28599570842563e-41 2.04347858117719e-38 1.11910964286754 0.622549019607843 18.2 18 2 increased insulin sensitivity 1.00263476013459e-10 4.98810793166958e-09 1.11880153493216 0.622377622377622 18.2 18 2 abnormal breathing pattern 0.000952690002184186 0.00849396552126581 1.11744252911992 0.621621621621622 18.2 18 2 glomerulosclerosis 3.98848596471176e-05 0.000557379709956208 1.1157672029893 0.620689655172414 18.2 18 2 abnormal microglial cell morphology 0.00346798345058162 0.0245422726410292 1.1157672029893 0.620689655172414 18.2 18 2 decreased granulocyte number 0.00346798345058162 0.0245422726410292 1.1157672029893 0.620689655172414 18.2 18 2 short snout 2.37783601170509e-08 7.68164555729403e-07 1.11519324866678 0.62037037037037 18.2 18 2 abnormal liver morphology 7.34353609856037e-13 6.19221899836234e-11 1.11472831360104 0.620111731843575 18.2 18 2 decreased double-positive T cell number 8.07842684918998e-08 2.35030254822925e-06 1.11452746165265 0.62 18.2 18 2 abnormal interventricular septum morphology 0.000139517911019544 0.00164810185816049 1.11452746165265 0.62 18.2 18 2 abnormal hindlimb morphology 0.000139517911019544 0.00164810185816049 1.11452746165265 0.62 18.2 18 2 cataract 3.75190252007073e-09 1.44744058069846e-07 1.1142303335637 0.619834710743802 18.2 18 2 increased circulating free fatty acid level 6.08113130224793e-06 0.000110819151020818 1.11402108843063 0.619718309859155 18.2 18 2 gliosis 2.10150878711671e-05 0.000323684402969214 1.11281543790203 0.619047619047619 18.2 18 2 skin edema 0.000493412920699173 0.0048037754999577 1.11281543790203 0.619047619047619 18.2 18 2 abnormal muscle morphology 0.000493412920699173 0.0048037754999577 1.11281543790203 0.619047619047619 18.2 18 2 small ears 0.0130406210482426 0.0671605483592205 1.11281543790203 0.619047619047619 18.2 18 2 abnormal eye pigmentation 0.0130406210482426 0.0671605483592205 1.11281543790203 0.619047619047619 18.2 18 2 abnormal hematopoietic system physiology 0.0130406210482426 0.0671605483592205 1.11281543790203 0.619047619047619 18.2 18 2 decreased cochlear outer hair cell number 0.0130406210482426 0.0671605483592205 1.11281543790203 0.619047619047619 18.2 18 2 vascular ring 0.0130406210482426 0.0671605483592205 1.11281543790203 0.619047619047619 18.2 18 2 increased muscle cell glucose uptake 0.0130406210482426 0.0671605483592205 1.11281543790203 0.619047619047619 18.2 18 2 increased exploration in new environment 1.70821050637232e-06 3.6009946055942e-05 1.10964502354903 0.617283950617284 18.2 18 2 decreased circulating HDL cholesterol level 1.94189330460083e-09 8.05076599199096e-08 1.1094716415141 0.6171875 18.2 18 2 decreased body length 1.83303851213185e-18 3.14460917167447e-16 1.10875406769071 0.616788321167883 18.2 18 2 abnormal kidney development 3.84159900507498e-05 0.000538364930992902 1.10853537852548 0.616666666666667 18.2 18 2 abnormal eating behavior 3.84159900507498e-05 0.000538364930992902 1.10853537852548 0.616666666666667 18.2 18 2 intracranial hemorrhage 3.84159900507498e-05 0.000538364930992902 1.10853537852548 0.616666666666667 18.2 18 2 muscular ventricular septal defect 3.84159900507498e-05 0.000538364930992902 1.10853537852548 0.616666666666667 18.2 18 2 enlarged heart 8.09268340309103e-16 1.03233589565072e-13 1.10801881963521 0.616379310344828 18.2 18 2 reduced female fertility 8.09268340309103e-16 1.03233589565072e-13 1.10801881963521 0.616379310344828 18.2 18 2 anemia 1.6999112673592e-14 1.79937416066213e-12 1.10754143108733 0.616113744075829 18.2 18 2 abnormal coat/hair pigmentation 2.22258976276905e-08 7.28843423770041e-07 1.10746536368135 0.616071428571429 18.2 18 2 abnormal snout morphology 0.000134044619296681 0.00159538751435643 1.10623073116888 0.615384615384615 18.2 18 2 abnormal iris morphology 0.000912447782031125 0.00820873004630172 1.10623073116888 0.615384615384615 18.2 18 2 abnormal xiphoid process morphology 0.00651935279662786 0.0393765251324302 1.10623073116888 0.615384615384615 18.2 18 2 abnormal kidney cortex morphology 0.00651935279662786 0.0393765251324302 1.10623073116888 0.615384615384615 18.2 18 2 increased susceptibility to otitis media 0.00651935279662786 0.0393765251324302 1.10623073116888 0.615384615384615 18.2 18 2 abnormal membranous labyrinth morphology 0.0521572330190493 0.186946854661218 1.10623073116888 0.615384615384615 18.2 18 2 short premaxilla 0.0521572330190493 0.186946854661218 1.10623073116888 0.615384615384615 18.2 18 2 absent trabeculae carneae 0.0521572330190493 0.186946854661218 1.10623073116888 0.615384615384615 18.2 18 2 increased foot pad pigmentation 0.0521572330190493 0.186946854661218 1.10623073116888 0.615384615384615 18.2 18 2 increased pituitary adenoma incidence 0.0521572330190493 0.186946854661218 1.10623073116888 0.615384615384615 18.2 18 2 abnormal lung interstitium morphology 0.0521572330190493 0.186946854661218 1.10623073116888 0.615384615384615 18.2 18 2 dystrophic cardiac calcinosis 0.0521572330190493 0.186946854661218 1.10623073116888 0.615384615384615 18.2 18 2 abnormal bile duct development 0.0521572330190493 0.186946854661218 1.10623073116888 0.615384615384615 18.2 18 2 anal atresia 0.0521572330190493 0.186946854661218 1.10623073116888 0.615384615384615 18.2 18 2 abnormal telomere length 0.0521572330190493 0.186946854661218 1.10623073116888 0.615384615384615 18.2 18 2 abnormal exocrine pancreas morphology 0.0521572330190493 0.186946854661218 1.10623073116888 0.615384615384615 18.2 18 2 abnormal vertebral arch development 0.0521572330190493 0.186946854661218 1.10623073116888 0.615384615384615 18.2 18 2 increased prostaglandin level 0.0521572330190493 0.186946854661218 1.10623073116888 0.615384615384615 18.2 18 2 abnormal aorta tunica media morphology 0.0521572330190493 0.186946854661218 1.10623073116888 0.615384615384615 18.2 18 2 abnormal rib morphology 1.00247342133678e-09 4.33678719230475e-08 1.10520644345484 0.614814814814815 18.2 18 2 decreased brain weight 7.0212165052428e-05 0.000924088680253517 1.10380478658298 0.614035087719298 18.2 18 2 small kidney 8.7283198727769e-07 2.01034219291968e-05 1.10308803022806 0.613636363636364 18.2 18 2 embryonic lethality, incomplete penetrance 0.000472430612871739 0.00462665806897028 1.10308803022806 0.613636363636364 18.2 18 2 decreased circulating glucose level 2.86403199870623e-18 4.74951973118783e-16 1.10177012338191 0.612903225806452 18.2 18 2 osteopetrosis 0.00330218339475769 0.0236379314948482 1.10177012338191 0.612903225806452 18.2 18 2 abnormal object recognition memory 0.00330218339475769 0.0236379314948482 1.10177012338191 0.612903225806452 18.2 18 2 abnormal retinal photoreceptor layer morphology 0.00330218339475769 0.0236379314948482 1.10177012338191 0.612903225806452 18.2 18 2 decreased thymus weight 0.00330218339475769 0.0236379314948482 1.10177012338191 0.612903225806452 18.2 18 2 abnormal podocyte morphology 0.00330218339475769 0.0236379314948482 1.10177012338191 0.612903225806452 18.2 18 2 increased or absent threshold for auditory brainstem response 8.22381197270871e-19 1.46119516300807e-16 1.10096752267283 0.612456747404844 18.2 18 2 polydactyly 2.46375097839186e-07 6.41736184162279e-06 1.10058669682618 0.612244897959184 18.2 18 2 decreased white adipose tissue amount 1.94074941841331e-05 0.000305545201158424 1.10003914125562 0.611940298507463 18.2 18 2 neonatal lethality, incomplete penetrance 5.7855497274401e-17 8.22374568400415e-15 1.09931678909908 0.611538461538462 18.2 18 2 diluted coat color 0.000128292357263986 0.00153426557064502 1.09854857331354 0.611111111111111 18.2 18 2 axon degeneration 0.000128292357263986 0.00153426557064502 1.09854857331354 0.611111111111111 18.2 18 2 lowered ear position 0.0249660556949582 0.109336379473959 1.09854857331354 0.611111111111111 18.2 18 2 cortical renal glomerulopathies 0.0249660556949582 0.109336379473959 1.09854857331354 0.611111111111111 18.2 18 2 abnormal white adipose tissue morphology 0.0249660556949582 0.109336379473959 1.09854857331354 0.611111111111111 18.2 18 2 absent ureter 0.0249660556949582 0.109336379473959 1.09854857331354 0.611111111111111 18.2 18 2 long tibia 0.0249660556949582 0.109336379473959 1.09854857331354 0.611111111111111 18.2 18 2 abnormal anterior eye segment morphology 0.0249660556949582 0.109336379473959 1.09854857331354 0.611111111111111 18.2 18 2 increased adipocyte glucose uptake 0.0249660556949582 0.109336379473959 1.09854857331354 0.611111111111111 18.2 18 2 decreased bone mineral content 8.84815408768354e-14 8.63128756592659e-12 1.09758830358162 0.610576923076923 18.2 18 2 azoospermia 7.59076398158128e-11 3.85347457228233e-09 1.09666427044336 0.610062893081761 18.2 18 2 abnormal mammary gland development 0.000869643770845244 0.00783782202890414 1.09611276716429 0.609756097560976 18.2 18 2 lethality at weaning, incomplete penetrance 0.000869643770845244 0.00783782202890414 1.09611276716429 0.609756097560976 18.2 18 2 short limbs 1.51476134996502e-06 3.26231069959999e-05 1.09510484737839 0.609195402298851 18.2 18 2 hydroencephaly 3.56348434715199e-08 1.09434164364698e-06 1.09420648409096 0.608695652173913 18.2 18 2 abnormal coat appearance 1.85675916765075e-05 0.000293853114257421 1.09420648409096 0.608695652173913 18.2 18 2 abnormal circulating insulin level 0.012293499265246 0.0649258586460707 1.09420648409096 0.608695652173913 18.2 18 2 dilated heart 0.012293499265246 0.0649258586460707 1.09420648409096 0.608695652173913 18.2 18 2 abnormal palatal shelf fusion at midline 0.012293499265246 0.0649258586460707 1.09420648409096 0.608695652173913 18.2 18 2 abnormal basicranium morphology 0.012293499265246 0.0649258586460707 1.09420648409096 0.608695652173913 18.2 18 2 abnormal myocardial fiber morphology 4.26365001254783e-07 1.06058294062127e-05 1.09340073557543 0.608247422680412 18.2 18 2 kinked tail 2.26520430960639e-07 5.96264097369936e-06 1.0926739820124 0.607843137254902 18.2 18 2 impaired balance 2.26520430960639e-07 5.96264097369936e-06 1.0926739820124 0.607843137254902 18.2 18 2 increased lung adenocarcinoma incidence 0.000234334394173605 0.00257923365268514 1.0926739820124 0.607843137254902 18.2 18 2 abnormal jaw morphology 0.00616212974639365 0.0374775005969541 1.0914151410193 0.607142857142857 18.2 18 2 abnormal ovulation 0.00616212974639365 0.0374775005969541 1.0914151410193 0.607142857142857 18.2 18 2 straub tail 0.00616212974639365 0.0374775005969541 1.0914151410193 0.607142857142857 18.2 18 2 abnormal retinal inner nuclear layer morphology 0.00616212974639365 0.0374775005969541 1.0914151410193 0.607142857142857 18.2 18 2 increased bone resorption 0.00616212974639365 0.0374775005969541 1.0914151410193 0.607142857142857 18.2 18 2 hypoxia 0.00616212974639365 0.0374775005969541 1.0914151410193 0.607142857142857 18.2 18 2 respiratory distress 1.99736658029349e-11 1.1690469102306e-09 1.09104403760515 0.606936416184971 18.2 18 2 abnormal long bone morphology 6.40972867372266e-05 0.000855125321081304 1.09036266740211 0.60655737704918 18.2 18 2 myeloid hyperplasia 0.00312690558771435 0.0226109815390681 1.0894696594845 0.606060606060606 18.2 18 2 abnormal vertebrae morphology 1.15161941538323e-07 3.23689637939636e-06 1.08847014603544 0.605504587155963 18.2 18 2 abnormal frontal bone morphology 0.00160102597577544 0.0131245839990705 1.08803614677466 0.605263157894737 18.2 18 2 decreased heart weight 4.93527475229651e-06 9.23044807995305e-05 1.08745212307805 0.604938271604938 18.2 18 2 abnormal blood circulation 0.000825389156111246 0.00746602009391536 1.08693600911361 0.604651162790698 18.2 18 2 limb grasping 9.78050446220249e-12 6.15924173410853e-10 1.08647661096944 0.604395604395604 18.2 18 2 premature death 3.64924891419898e-50 3.02583555802332e-47 1.0856735979532 0.603948896631823 18.2 18 2 increased circulating aspartate transaminase level 6.09768152687676e-05 0.000822112888786229 1.08428170872505 0.603174603174603 18.2 18 2 decreased grip strength 1.17180654122591e-13 1.09995047973565e-11 1.0834999627202 0.602739726027397 18.2 18 2 abnormal heart ventricle morphology 8.89633431994102e-06 0.000155295660497216 1.08318425760286 0.602564102564103 18.2 18 2 short tail 4.70023473632264e-06 8.82402558988873e-05 1.08290658924665 0.602409638554217 18.2 18 2 lethargy 1.31739056296025e-06 2.8745693204944e-05 1.0824408229717 0.602150537634409 18.2 18 2 hypoactivity 2.47498011027578e-22 5.5968300221009e-20 1.08238955161783 0.602122015915119 18.2 18 2 abnormal heart morphology 3.20228545492923e-14 3.25130002821896e-12 1.08168773334533 0.601731601731602 18.2 18 2 abnormal lens morphology 1.58158624856114e-08 5.35264733781747e-07 1.08138375185552 0.6015625 18.2 18 2 decreased lymphocyte cell number 1.58158624856114e-08 5.35264733781747e-07 1.08138375185552 0.6015625 18.2 18 2 decreased body size 1.14950265444166e-45 8.16967957978178e-43 1.08127815828537 0.601503759398496 18.2 18 2 abnormal lipid homeostasis 1.50587521846406e-08 5.16670980128187e-07 1.07857496288966 0.6 18.2 18 2 abnormal nervous system physiology 9.97299451378608e-08 2.83517986891918e-06 1.07857496288966 0.6 18.2 18 2 abnormal rostral-caudal axis patterning 0.000211053696077564 0.00234373245086134 1.07857496288966 0.6 18.2 18 2 increased body length 0.000405044824905185 0.00403827255291241 1.07857496288966 0.6 18.2 18 2 decreased respiratory quotient 0.000405044824905185 0.00403827255291241 1.07857496288966 0.6 18.2 18 2 cardiomyopathy 0.000780569023636386 0.00708637024195441 1.07857496288966 0.6 18.2 18 2 increased red blood cell distribution width 0.00294745920167886 0.0215324662677714 1.07857496288966 0.6 18.2 18 2 abnormal thyroid gland morphology 0.0115179694247878 0.0616149439659345 1.07857496288966 0.6 18.2 18 2 increased liver glycogen level 0.0115179694247878 0.0616149439659345 1.07857496288966 0.6 18.2 18 2 abnormal cell proliferation 0.0232638162503317 0.10608385503703 1.07857496288966 0.6 18.2 18 2 abnormal hair texture 0.0232638162503317 0.10608385503703 1.07857496288966 0.6 18.2 18 2 decreased myocardial infarction size 0.0232638162503317 0.10608385503703 1.07857496288966 0.6 18.2 18 2 abnormal lens epithelium morphology 0.0232638162503317 0.10608385503703 1.07857496288966 0.6 18.2 18 2 dilated vasculature 0.0232638162503317 0.10608385503703 1.07857496288966 0.6 18.2 18 2 abnormal response to tactile stimuli 0.0232638162503317 0.10608385503703 1.07857496288966 0.6 18.2 18 2 increased urine calcium level 0.0232638162503317 0.10608385503703 1.07857496288966 0.6 18.2 18 2 abnormal neuron proliferation 0.0232638162503317 0.10608385503703 1.07857496288966 0.6 18.2 18 2 decreased muscle cell glucose uptake 0.0232638162503317 0.10608385503703 1.07857496288966 0.6 18.2 18 2 abnormal auchene hair morphology 0.103964763834746 0.308055211481751 1.07857496288966 0.6 18.2 18 2 jaundice 0.103964763834746 0.308055211481751 1.07857496288966 0.6 18.2 18 2 abnormal optic nerve innervation 0.103964763834746 0.308055211481751 1.07857496288966 0.6 18.2 18 2 rhinitis 0.103964763834746 0.308055211481751 1.07857496288966 0.6 18.2 18 2 abnormal gland morphology 0.103964763834746 0.308055211481751 1.07857496288966 0.6 18.2 18 2 primary sex reversal 0.103964763834746 0.308055211481751 1.07857496288966 0.6 18.2 18 2 impaired basement membrane formation 0.103964763834746 0.308055211481751 1.07857496288966 0.6 18.2 18 2 abnormal tibialis anterior morphology 0.103964763834746 0.308055211481751 1.07857496288966 0.6 18.2 18 2 peritoneal inflammation 0.103964763834746 0.308055211481751 1.07857496288966 0.6 18.2 18 2 abnormal submandibular gland morphology 0.103964763834746 0.308055211481751 1.07857496288966 0.6 18.2 18 2 increased atrioventricular cushion size 0.103964763834746 0.308055211481751 1.07857496288966 0.6 18.2 18 2 abnormal pillar cell morphology 0.103964763834746 0.308055211481751 1.07857496288966 0.6 18.2 18 2 abnormal hindlimb zeugopod morphology 0.103964763834746 0.308055211481751 1.07857496288966 0.6 18.2 18 2 absent pharyngeal arches 0.103964763834746 0.308055211481751 1.07857496288966 0.6 18.2 18 2 abnormal ear physiology 0.103964763834746 0.308055211481751 1.07857496288966 0.6 18.2 18 2 abnormal reproductive system development 0.103964763834746 0.308055211481751 1.07857496288966 0.6 18.2 18 2 abnormal gas homeostasis 0.103964763834746 0.308055211481751 1.07857496288966 0.6 18.2 18 2 abnormal deltoid tuberosity morphology 0.103964763834746 0.308055211481751 1.07857496288966 0.6 18.2 18 2 decreased cochlear inner hair cell number 0.103964763834746 0.308055211481751 1.07857496288966 0.6 18.2 18 2 absent coat pigmentation 0.103964763834746 0.308055211481751 1.07857496288966 0.6 18.2 18 2 abnormal corneal endothelium morphology 0.103964763834746 0.308055211481751 1.07857496288966 0.6 18.2 18 2 increased susceptibility to atherosclerosis 0.103964763834746 0.308055211481751 1.07857496288966 0.6 18.2 18 2 tachypnea 0.103964763834746 0.308055211481751 1.07857496288966 0.6 18.2 18 2 vascular smooth muscle hyperplasia 0.103964763834746 0.308055211481751 1.07857496288966 0.6 18.2 18 2 increased platelet aggregation 0.103964763834746 0.308055211481751 1.07857496288966 0.6 18.2 18 2 protruding tongue 0.103964763834746 0.308055211481751 1.07857496288966 0.6 18.2 18 2 umbilical hernia 0.103964763834746 0.308055211481751 1.07857496288966 0.6 18.2 18 2 increased kidney iron level 0.103964763834746 0.308055211481751 1.07857496288966 0.6 18.2 18 2 abnormal heart and great artery attachment 0.103964763834746 0.308055211481751 1.07857496288966 0.6 18.2 18 2 common ventricle 0.103964763834746 0.308055211481751 1.07857496288966 0.6 18.2 18 2 thick aortic valve 0.103964763834746 0.308055211481751 1.07857496288966 0.6 18.2 18 2 decreased macrophage cytokine production 0.103964763834746 0.308055211481751 1.07857496288966 0.6 18.2 18 2 liver inflammation 5.3074806756496e-08 1.57170930722362e-06 1.07857496288966 0.6 18.2 18 2 abnormal incisor morphology 0.000110349110893666 0.00134555594778429 1.07857496288966 0.6 18.2 18 2 delayed eyelid opening 0.00579398804168072 0.0357762327589088 1.07857496288966 0.6 18.2 18 2 disorganized myocardium 0.00579398804168072 0.0357762327589088 1.07857496288966 0.6 18.2 18 2 abnormal spleen marginal zone morphology 0.00579398804168072 0.0357762327589088 1.07857496288966 0.6 18.2 18 2 liver hemorrhage 0.00579398804168072 0.0357762327589088 1.07857496288966 0.6 18.2 18 2 abnormal fat pad morphology 0.00579398804168072 0.0357762327589088 1.07857496288966 0.6 18.2 18 2 abnormal fontanelle morphology 0.0481474225198116 0.174969632604867 1.07857496288966 0.6 18.2 18 2 abnormal prostate gland morphology 0.0481474225198116 0.174969632604867 1.07857496288966 0.6 18.2 18 2 abnormal epidermis stratum spinosum morphology 0.0481474225198116 0.174969632604867 1.07857496288966 0.6 18.2 18 2 absent egg cylinders 0.0481474225198116 0.174969632604867 1.07857496288966 0.6 18.2 18 2 placental labyrinth hypoplasia 0.0481474225198116 0.174969632604867 1.07857496288966 0.6 18.2 18 2 abnormal cricoid cartilage morphology 0.0481474225198116 0.174969632604867 1.07857496288966 0.6 18.2 18 2 abnormal bronchus morphology 0.0481474225198116 0.174969632604867 1.07857496288966 0.6 18.2 18 2 dilated ureter 0.0481474225198116 0.174969632604867 1.07857496288966 0.6 18.2 18 2 abnormal pericyte morphology 0.0481474225198116 0.174969632604867 1.07857496288966 0.6 18.2 18 2 abnormal trophectoderm morphology 0.0481474225198116 0.174969632604867 1.07857496288966 0.6 18.2 18 2 abnormal energy homeostasis 0.0481474225198116 0.174969632604867 1.07857496288966 0.6 18.2 18 2 abnormal coronary vessel morphology 0.0481474225198116 0.174969632604867 1.07857496288966 0.6 18.2 18 2 decreased brown adipose tissue mass 0.0481474225198116 0.174969632604867 1.07857496288966 0.6 18.2 18 2 decreased body weight 1.43421640827416e-69 3.56761331558198e-66 1.07741333126565 0.59935379644588 18.2 18 2 abnormal motor capabilities/coordination/movement 1.43203375464362e-08 5.01716051362816e-07 1.07585128874095 0.598484848484849 18.2 18 2 abnormal retinal pigmentation 4.23894101299142e-06 8.0185291025218e-05 1.07444249176748 0.597701149425287 18.2 18 2 hydrops fetalis 2.88130968624015e-05 0.000422847070473296 1.07358156028369 0.597222222222222 18.2 18 2 reduced fertility 7.25335095983991e-09 2.59607345505062e-07 1.07340194148491 0.597122302158273 18.2 18 2 postnatal lethality, incomplete penetrance 1.23160287792049e-31 6.12722431765445e-29 1.072878264142 0.596830985915493 18.2 18 2 decreased kidney weight 0.000382381204706208 0.00385090383282062 1.07166102081985 0.596153846153846 18.2 18 2 abnormal seminiferous tubule morphology 3.67284894898792e-09 1.43877350560747e-07 1.07118746314384 0.595890410958904 18.2 18 2 abnormal pancreas morphology 0.00142292443282476 0.0118181119420755 1.07001484413657 0.595238095238095 18.2 18 2 decreased B cell proliferation 1.43676388502363e-05 0.000233591513986685 1.06947306446865 0.594936708860759 18.2 18 2 abnormal vocalization 0.00276780576037048 0.0202795782884288 1.06885807133209 0.594594594594595 18.2 18 2 small testis 8.49367237673835e-16 1.05640050185683e-13 1.06815394875546 0.594202898550725 18.2 18 2 ataxia 5.96083237789316e-12 3.90199224737085e-10 1.06789600286105 0.594059405940594 18.2 18 2 decreased bone mineral density 2.96387396255439e-15 3.35119840084275e-13 1.06776218130681 0.593984962406015 18.2 18 2 increased circulating follicle stimulating hormone level 0.00542491327683741 0.0348244432932466 1.06733980702622 0.59375 18.2 18 2 abnormal maxilla morphology 0.00036007063952096 0.00363357288360401 1.06525922260707 0.592592592592593 18.2 18 2 rectal prolapse 0.0107405575756031 0.0577667826363519 1.06525922260707 0.592592592592593 18.2 18 2 abnormal trigeminal nerve morphology 0.0107405575756031 0.0577667826363519 1.06525922260707 0.592592592592593 18.2 18 2 abnormal skin appearance 0.0107405575756031 0.0577667826363519 1.06525922260707 0.592592592592593 18.2 18 2 abnormal skeletal muscle fiber morphology 4.88014806373025e-05 0.000661545956868065 1.06338376622924 0.591549295774648 18.2 18 2 increased T cell number 6.7697740789769e-06 0.000121587097627834 1.06223291799739 0.590909090909091 18.2 18 2 omphalocele 0.00133521816301275 0.0112588311203194 1.06223291799739 0.590909090909091 18.2 18 2 increased coping response 0.021564021206997 0.0993342643563054 1.06223291799739 0.590909090909091 18.2 18 2 aphakia 0.021564021206997 0.0993342643563054 1.06223291799739 0.590909090909091 18.2 18 2 prolonged PR interval 0.021564021206997 0.0993342643563054 1.06223291799739 0.590909090909091 18.2 18 2 abnormal basement membrane morphology 0.021564021206997 0.0993342643563054 1.06223291799739 0.590909090909091 18.2 18 2 abnormal sperm midpiece morphology 0.021564021206997 0.0993342643563054 1.06223291799739 0.590909090909091 18.2 18 2 pulmonary vascular congestion 0.021564021206997 0.0993342643563054 1.06223291799739 0.590909090909091 18.2 18 2 abnormal bone structure 3.30058127674058e-11 1.8206663453212e-09 1.06180954895873 0.590673575129534 18.2 18 2 absent gastric milk in neonates 2.42259513010976e-05 0.000364080758547888 1.06013778403684 0.58974358974359 18.2 18 2 abnormal heart looping 0.0025908571292829 0.0190391642809194 1.06013778403684 0.58974358974359 18.2 18 2 seminiferous tubule degeneration 4.59374945607995e-05 0.00062958411966936 1.05887496356747 0.589041095890411 18.2 18 2 decreased percent body fat/body weight 4.59374945607995e-05 0.00062958411966936 1.05887496356747 0.589041095890411 18.2 18 2 impaired synaptic plasticity 0.00506194377746347 0.0327479457644743 1.05742643420555 0.588235294117647 18.2 18 2 abnormal cranial suture morphology 0.0441990012487235 0.168539609394208 1.05742643420555 0.588235294117647 18.2 18 2 nephrocalcinosis 0.0441990012487235 0.168539609394208 1.05742643420555 0.588235294117647 18.2 18 2 abnormal involuntary movement 0.0441990012487235 0.168539609394208 1.05742643420555 0.588235294117647 18.2 18 2 abnormal tarsal bone morphology 0.0441990012487235 0.168539609394208 1.05742643420555 0.588235294117647 18.2 18 2 abnormal cell cytoskeleton morphology 0.0441990012487235 0.168539609394208 1.05742643420555 0.588235294117647 18.2 18 2 increased kidney weight 0.000648916868807437 0.00598953881691466 1.05742643420555 0.588235294117647 18.2 18 2 abnormal forelimb morphology 0.00124974097830235 0.010610002332857 1.05512768108771 0.58695652173913 18.2 18 2 abnormal myelin sheath morphology 0.00124974097830235 0.010610002332857 1.05512768108771 0.58695652173913 18.2 18 2 abnormal bone mineralization 2.26011508535946e-07 5.96264097369936e-06 1.05480471577363 0.586776859504132 18.2 18 2 increased circulating triglyceride level 1.62626739940844e-08 5.466675886525e-07 1.05378013615656 0.586206896551724 18.2 18 2 abnormal parietal bone morphology 0.00997883699879406 0.054667652743338 1.05378013615656 0.586206896551724 18.2 18 2 focal hair loss 0.00997883699879406 0.054667652743338 1.05378013615656 0.586206896551724 18.2 18 2 abnormal enzyme/coenzyme activity 4.37755590965744e-09 1.64987429170801e-07 1.05338531407483 0.585987261146497 18.2 18 2 dehydration 8.19236769919172e-05 0.00104203394277594 1.05289460663038 0.585714285714286 18.2 18 2 Leydig cell hyperplasia 0.00241871075728153 0.0179063780021959 1.05226825647772 0.585365853658537 18.2 18 2 increased circulating cholesterol level 5.95096859716124e-10 2.69146079735247e-08 1.05201913993972 0.585227272727273 18.2 18 2 cleft secondary palate 5.64346186633062e-06 0.000103602298099612 1.05180182551297 0.585106382978723 18.2 18 2 postnatal lethality 2.07579123365023e-09 8.48442010118737e-08 1.05041939156925 0.58433734939759 18.2 18 2 increased startle reflex 1.06411401340134e-05 0.000181923272050573 1.05029771667158 0.584269662921348 18.2 18 2 abnormal pulmonary alveolus morphology 2.81513795660105e-06 5.64730295729445e-05 1.0500977361467 0.584158415841584 18.2 18 2 insulin resistance 1.00345195602556e-07 2.83646220524271e-06 1.04861454725383 0.583333333333333 18.2 18 2 retinal degeneration 5.29842719066564e-06 9.83569972894088e-05 1.04861454725383 0.583333333333333 18.2 18 2 cochlear outer hair cell degeneration 7.67852179221637e-05 0.000994808487403032 1.04861454725383 0.583333333333333 18.2 18 2 epidermal hyperplasia 0.000296887143600347 0.00303912250907763 1.04861454725383 0.583333333333333 18.2 18 2 abnormal long bone epiphyseal plate morphology 0.000296887143600347 0.00303912250907763 1.04861454725383 0.583333333333333 18.2 18 2 abnormal phalanx morphology 0.00116715860206189 0.00995988687008219 1.04861454725383 0.583333333333333 18.2 18 2 heart right ventricle hypertrophy 0.00470993524524403 0.03058998413197 1.04861454725383 0.583333333333333 18.2 18 2 abnormal malleus morphology 0.0199120301122708 0.0928419398393131 1.04861454725383 0.583333333333333 18.2 18 2 abnormal digestive system morphology 0.0199120301122708 0.0928419398393131 1.04861454725383 0.583333333333333 18.2 18 2 blindness 0.0199120301122708 0.0928419398393131 1.04861454725383 0.583333333333333 18.2 18 2 abnormal primitive streak formation 0.0199120301122708 0.0928419398393131 1.04861454725383 0.583333333333333 18.2 18 2 abnormal tumor morphology 0.0199120301122708 0.0928419398393131 1.04861454725383 0.583333333333333 18.2 18 2 abnormal mineral level 0.0937103737819611 0.286193437424958 1.04861454725383 0.583333333333333 18.2 18 2 mesocardia 0.0937103737819611 0.286193437424958 1.04861454725383 0.583333333333333 18.2 18 2 abnormal superior cervical ganglion morphology 0.0937103737819611 0.286193437424958 1.04861454725383 0.583333333333333 18.2 18 2 abnormal enteric nervous system morphology 0.0937103737819611 0.286193437424958 1.04861454725383 0.583333333333333 18.2 18 2 absent optic nerve 0.0937103737819611 0.286193437424958 1.04861454725383 0.583333333333333 18.2 18 2 increased papilloma incidence 0.0937103737819611 0.286193437424958 1.04861454725383 0.583333333333333 18.2 18 2 altered tumor susceptibility 0.0937103737819611 0.286193437424958 1.04861454725383 0.583333333333333 18.2 18 2 decreased synaptic depression 0.0937103737819611 0.286193437424958 1.04861454725383 0.583333333333333 18.2 18 2 abnormal gastrocnemius morphology 0.0937103737819611 0.286193437424958 1.04861454725383 0.583333333333333 18.2 18 2 small intestinal inflammation 0.0937103737819611 0.286193437424958 1.04861454725383 0.583333333333333 18.2 18 2 decreased circulating ketone body level 0.0937103737819611 0.286193437424958 1.04861454725383 0.583333333333333 18.2 18 2 increased fear-related response 0.0937103737819611 0.286193437424958 1.04861454725383 0.583333333333333 18.2 18 2 abnormal vascular endothelial cell development 0.0937103737819611 0.286193437424958 1.04861454725383 0.583333333333333 18.2 18 2 abnormal nucleotide metabolism 0.0937103737819611 0.286193437424958 1.04861454725383 0.583333333333333 18.2 18 2 increased hepatocyte proliferation 0.0937103737819611 0.286193437424958 1.04861454725383 0.583333333333333 18.2 18 2 bowed ulna 0.0937103737819611 0.286193437424958 1.04861454725383 0.583333333333333 18.2 18 2 hydrometra 0.0937103737819611 0.286193437424958 1.04861454725383 0.583333333333333 18.2 18 2 reduced cerebellar foliation 0.0937103737819611 0.286193437424958 1.04861454725383 0.583333333333333 18.2 18 2 increased fibrosarcoma incidence 0.0937103737819611 0.286193437424958 1.04861454725383 0.583333333333333 18.2 18 2 abnormal skeleton morphology 7.03222231175712e-07 1.65025028306564e-05 1.04731192048706 0.582608695652174 18.2 18 2 abnormal glucose homeostasis 4.95365603124059e-10 2.30321857527308e-08 1.04696837057055 0.582417582417582 18.2 18 2 small spleen 9.98143550051123e-06 0.000173023141515831 1.04696837057055 0.582417582417582 18.2 18 2 decreased hematocrit 2.53038496606954e-08 8.12171948786836e-07 1.04656246399111 0.582191780821918 18.2 18 2 abnormal left-right axis patterning 0.00225283453937132 0.0168792949297776 1.04513077799386 0.581395348837209 18.2 18 2 small seminiferous tubules 7.18687472747397e-05 0.000940913204452184 1.04456584243818 0.581081081081081 18.2 18 2 abnormal retina morphology 3.19593591176947e-11 1.79540284359934e-09 1.04433448787729 0.580952380952381 18.2 18 2 decreased double-negative T cell number 0.0092441790912664 0.0513852413173747 1.04378222215128 0.580645161290323 18.2 18 2 small cranium 0.0092441790912664 0.0513852413173747 1.04378222215128 0.580645161290323 18.2 18 2 preaxial polydactyly 0.0092441790912664 0.0513852413173747 1.04378222215128 0.580645161290323 18.2 18 2 postnatal lethality, complete penetrance 2.82914683205354e-19 5.63000219578655e-17 1.0431813112577 0.580310880829015 18.2 18 2 abnormal skeleton development 3.55371199591341e-05 0.000508037849990495 1.04306632213609 0.580246913580247 18.2 18 2 decreased circulating alkaline phosphatase level 0.00108793493114185 0.00931579394566388 1.04262246412667 0.58 18.2 18 2 testicular atrophy 0.00108793493114185 0.00931579394566388 1.04262246412667 0.58 18.2 18 2 abnormal axon extension 0.00108793493114185 0.00931579394566388 1.04262246412667 0.58 18.2 18 2 hyperglycemia 1.76179348937359e-05 0.000280029476346122 1.04180536188206 0.579545454545455 18.2 18 2 alopecia 8.75355460362628e-06 0.000153341317440284 1.04073022734967 0.578947368421053 18.2 18 2 increased bone marrow cell number 0.00437212796418865 0.0284703358924588 1.04073022734967 0.578947368421053 18.2 18 2 irregular coat pigmentation 0.0404296706522281 0.160153460157127 1.04073022734967 0.578947368421053 18.2 18 2 unresponsive to tactile stimuli 0.0404296706522281 0.160153460157127 1.04073022734967 0.578947368421053 18.2 18 2 abnormal neural crest cell migration 0.0404296706522281 0.160153460157127 1.04073022734967 0.578947368421053 18.2 18 2 abnormal metatarsal bone morphology 0.0404296706522281 0.160153460157127 1.04073022734967 0.578947368421053 18.2 18 2 increased susceptibility to ischemic brain injury 0.0404296706522281 0.160153460157127 1.04073022734967 0.578947368421053 18.2 18 2 abnormal digestive system development 0.0404296706522281 0.160153460157127 1.04073022734967 0.578947368421053 18.2 18 2 Leydig cell hypoplasia 0.0404296706522281 0.160153460157127 1.04073022734967 0.578947368421053 18.2 18 2 decreased circulating magnesium level 0.0404296706522281 0.160153460157127 1.04073022734967 0.578947368421053 18.2 18 2 shortened RR interval 0.0404296706522281 0.160153460157127 1.04073022734967 0.578947368421053 18.2 18 2 abnormal tooth morphology 0.000258855755151855 0.00280568057054571 1.03925191736764 0.578125 18.2 18 2 small placenta 0.00209421172215937 0.0157382225343547 1.03862774204189 0.577777777777778 18.2 18 2 abnormal ovary morphology 0.000127190678676558 0.00152843871114945 1.03806510512854 0.577464788732394 18.2 18 2 corneal opacity 0.000127190678676558 0.00152843871114945 1.03806510512854 0.577464788732394 18.2 18 2 decreased cardiac muscle contractility 4.07481523235519e-06 7.73748312250652e-05 1.03709131047083 0.576923076923077 18.2 18 2 abnormal stomach morphology 0.0183342648268239 0.0861312252251642 1.03709131047083 0.576923076923077 18.2 18 2 thick skin 0.0183342648268239 0.0861312252251642 1.03709131047083 0.576923076923077 18.2 18 2 decreased bone resorption 0.0183342648268239 0.0861312252251642 1.03709131047083 0.576923076923077 18.2 18 2 abnormal thoracic vertebrae morphology 0.000492818669284388 0.0048037754999577 1.03591945588272 0.576271186440678 18.2 18 2 abnormal vascular development 0.000241212178664965 0.00264323918250705 1.03499617651028 0.575757575757576 18.2 18 2 abnormal tail morphology 0.000241212178664965 0.00264323918250705 1.03499617651028 0.575757575757576 18.2 18 2 abnormal tooth development 0.00854363799779009 0.0478116974566993 1.03499617651028 0.575757575757576 18.2 18 2 abnormal posture 5.85011435270134e-05 0.000790878231105684 1.03363433943592 0.575 18.2 18 2 abnormal spleen morphology 4.05103872356056e-09 1.53846699616136e-07 1.03311778054565 0.574712643678161 18.2 18 2 abnormal cranium morphology 2.37231194438114e-07 6.21171153857694e-06 1.03296358386199 0.574626865671642 18.2 18 2 male infertility 1.57372149053973e-23 4.34959134190842e-21 1.03283023285325 0.57455268389662 18.2 18 2 abnormal innervation 0.00194345432624322 0.0151309628686385 1.03267815595818 0.574468085106383 18.2 18 2 impaired limb coordination 0.000940657385685183 0.00841685340608594 1.0319698719006 0.574074074074074 18.2 18 2 abnormal osteoblast physiology 0.000940657385685183 0.00841685340608594 1.0319698719006 0.574074074074074 18.2 18 2 abnormal testis morphology 1.77283424762094e-06 3.72145585734776e-05 1.03168039928576 0.573913043478261 18.2 18 2 cyanosis 8.94727855435244e-10 3.93917794760207e-08 1.02988928748144 0.572916666666667 18.2 18 2 abnormal urine homeostasis 1.33884816210124e-05 0.000218385888736187 1.02988928748144 0.572916666666667 18.2 18 2 reduced male fertility 2.89041235622619e-11 1.65285074393394e-09 1.02947683682567 0.572687224669604 18.2 18 2 impaired glucose tolerance 3.6932666612994e-12 2.55194467221729e-10 1.02928524684363 0.57258064516129 18.2 18 2 reduced long term potentiation 3.09123025004411e-06 6.15154819758778e-05 1.0272142503711 0.571428571428571 18.2 18 2 spleen hypoplasia 6.20422258621443e-06 0.000112484973827981 1.0272142503711 0.571428571428571 18.2 18 2 disheveled coat 0.00374642585655722 0.0257793480447748 1.0272142503711 0.571428571428571 18.2 18 2 abnormal dermal layer morphology 0.00788125654517628 0.0442542339867404 1.0272142503711 0.571428571428571 18.2 18 2 corneal vascularization 0.0168451280145491 0.0799661372828071 1.0272142503711 0.571428571428571 18.2 18 2 prolonged QRS complex duration 0.0168451280145491 0.0799661372828071 1.0272142503711 0.571428571428571 18.2 18 2 abnormal salivary gland morphology 0.0368947431864503 0.14790600108992 1.0272142503711 0.571428571428571 18.2 18 2 complete atrioventricular septal defect 0.0368947431864503 0.14790600108992 1.0272142503711 0.571428571428571 18.2 18 2 abnormal interparietal bone morphology 0.0843324989984977 0.262514129520369 1.0272142503711 0.571428571428571 18.2 18 2 abnormal kidney blood vessel morphology 0.0843324989984977 0.262514129520369 1.0272142503711 0.571428571428571 18.2 18 2 absent visceral yolk sac blood islands 0.0843324989984977 0.262514129520369 1.0272142503711 0.571428571428571 18.2 18 2 abnormal fluid regulation 0.0843324989984977 0.262514129520369 1.0272142503711 0.571428571428571 18.2 18 2 abnormal vascular endothelial cell migration 0.0843324989984977 0.262514129520369 1.0272142503711 0.571428571428571 18.2 18 2 abnormal sagittal suture morphology 0.0843324989984977 0.262514129520369 1.0272142503711 0.571428571428571 18.2 18 2 enlarged stomach 0.0843324989984977 0.262514129520369 1.0272142503711 0.571428571428571 18.2 18 2 premature hair loss 0.0843324989984977 0.262514129520369 1.0272142503711 0.571428571428571 18.2 18 2 abnormal glucose tolerance 0.0843324989984977 0.262514129520369 1.0272142503711 0.571428571428571 18.2 18 2 increased pulmonary respiratory rate 0.0843324989984977 0.262514129520369 1.0272142503711 0.571428571428571 18.2 18 2 decreased tongue size 0.0843324989984977 0.262514129520369 1.0272142503711 0.571428571428571 18.2 18 2 abnormal kidney morphology 6.13879257240275e-09 2.21307920635534e-07 1.0272142503711 0.571428571428571 18.2 18 2 abnormal blood homeostasis 2.87978511348327e-06 5.75378752593546e-05 1.02496158754134 0.570175438596491 18.2 18 2 abnormal placenta labyrinth morphology 9.54920207588655e-05 0.00119665693520241 1.0239635723636 0.569620253164557 18.2 18 2 abnormal myocardium layer morphology 9.54920207588655e-05 0.00119665693520241 1.0239635723636 0.569620253164557 18.2 18 2 thrombocytosis 0.000809008758224862 0.00733118137007047 1.02278660274019 0.568965517241379 18.2 18 2 abnormal renal glomerulus morphology 5.37740744611127e-06 9.94520522096788e-05 1.02250225839692 0.568807339449541 18.2 18 2 distended abdomen 0.00166664055876449 0.0133734464191183 1.0221788863987 0.568627450980392 18.2 18 2 cochlear inner hair cell degeneration 0.00166664055876449 0.0133734464191183 1.0221788863987 0.568627450980392 18.2 18 2 abnormal angiogenesis 0.000179885993113762 0.00201108497919319 1.02027361354427 0.567567567567568 18.2 18 2 impaired skeletal muscle contractility 0.00725898019414054 0.0417979472984366 1.02027361354427 0.567567567567568 18.2 18 2 decreased circulating chloride level 0.00725898019414054 0.0417979472984366 1.02027361354427 0.567567567567568 18.2 18 2 abnormal pancreatic beta cell physiology 0.00725898019414054 0.0417979472984366 1.02027361354427 0.567567567567568 18.2 18 2 abnormal calcium ion homeostasis 0.00725898019414054 0.0417979472984366 1.02027361354427 0.567567567567568 18.2 18 2 abnormal response to new environment 0.0154513317888653 0.0758090489641071 1.01865413161801 0.566666666666667 18.2 18 2 abnormal pancreatic islet morphology 0.00154065764339127 0.012753364019753 1.0175235498959 0.566037735849057 18.2 18 2 increased circulating bilirubin level 0.00154065764339127 0.012753364019753 1.0175235498959 0.566037735849057 18.2 18 2 increased lymphocyte cell number 0.000339208875123195 0.00343000844255669 1.01604887808446 0.565217391304348 18.2 18 2 abnormal inner ear morphology 0.00319202368917349 0.0230149534110697 1.01604887808446 0.565217391304348 18.2 18 2 bidirectional circling 0.0336156997312733 0.135525207587589 1.01604887808446 0.565217391304348 18.2 18 2 conjunctivitis 0.0336156997312733 0.135525207587589 1.01604887808446 0.565217391304348 18.2 18 2 abnormal hepatocyte physiology 0.0336156997312733 0.135525207587589 1.01604887808446 0.565217391304348 18.2 18 2 circling 7.63094977022759e-05 0.000991226504096143 1.01512937683733 0.564705882352941 18.2 18 2 decreased startle reflex 4.0099956781365e-06 7.64357413744409e-05 1.01404483690481 0.564102564102564 18.2 18 2 increased circulating alanine transaminase level 0.000154516986023693 0.00177124886052505 1.01404483690481 0.564102564102564 18.2 18 2 increased urine protein level 0.000154516986023693 0.00177124886052505 1.01404483690481 0.564102564102564 18.2 18 2 abnormal circulating hormone level 0.00667730198583142 0.0398794446332669 1.01404483690481 0.564102564102564 18.2 18 2 decreased circulating calcium level 0.00142278336778524 0.0118181119420755 1.01320678332059 0.563636363636364 18.2 18 2 enlarged spleen 8.94383129188699e-13 7.41592677952297e-11 1.01116402770905 0.5625 18.2 18 2 abnormal heart atrium morphology 0.014154663709818 0.071433582118386 1.01116402770905 0.5625 18.2 18 2 abnormal depression-related behavior 0.014154663709818 0.071433582118386 1.01116402770905 0.5625 18.2 18 2 absent mandible 0.0758575599529026 0.239613562390915 1.01116402770905 0.5625 18.2 18 2 abnormal hair follicle orientation 0.0758575599529026 0.239613562390915 1.01116402770905 0.5625 18.2 18 2 poor circulation 0.0758575599529026 0.239613562390915 1.01116402770905 0.5625 18.2 18 2 abnormal intestinal absorption 0.0758575599529026 0.239613562390915 1.01116402770905 0.5625 18.2 18 2 abnormal extraembryonic endoderm formation 0.0758575599529026 0.239613562390915 1.01116402770905 0.5625 18.2 18 2 increased intestinal adenocarcinoma incidence 0.0758575599529026 0.239613562390915 1.01116402770905 0.5625 18.2 18 2 abnormal epicardium morphology 0.0758575599529026 0.239613562390915 1.01116402770905 0.5625 18.2 18 2 decreased aggression towards mice 0.0758575599529026 0.239613562390915 1.01116402770905 0.5625 18.2 18 2 sepsis 0.0758575599529026 0.239613562390915 1.01116402770905 0.5625 18.2 18 2 decreased circulating growth hormone level 0.0758575599529026 0.239613562390915 1.01116402770905 0.5625 18.2 18 2 dystonia 0.0758575599529026 0.239613562390915 1.01116402770905 0.5625 18.2 18 2 decreased circulating triiodothyronine level 0.0758575599529026 0.239613562390915 1.01116402770905 0.5625 18.2 18 2 kidney degeneration 0.0758575599529026 0.239613562390915 1.01116402770905 0.5625 18.2 18 2 decreased midbrain size 0.0758575599529026 0.239613562390915 1.01116402770905 0.5625 18.2 18 2 decreased fibroblast apoptosis 0.0758575599529026 0.239613562390915 1.01116402770905 0.5625 18.2 18 2 decreased litter size 1.77325164577658e-12 1.34372962472509e-10 1.01076420009826 0.562277580071174 18.2 18 2 decreased bone marrow cell number 0.000290304695842354 0.00303241582153237 1.00962496526201 0.561643835616438 18.2 18 2 increased bone trabecula number 0.00613572064811508 0.0374775005969541 1.00842374579114 0.560975609756098 18.2 18 2 impaired coordination 8.15599927256822e-15 8.82089051761454e-13 1.00791687283523 0.560693641618497 18.2 18 2 decreased heart rate 2.78556066965761e-05 0.000411221493517704 1.00666996536368 0.56 18.2 18 2 decreased oocyte number 0.00270829155455806 0.0198727883243751 1.00666996536368 0.56 18.2 18 2 abnormal nest building behavior 0.0305953800781584 0.12395115300394 1.00666996536368 0.56 18.2 18 2 diaphragmatic hernia 0.0305953800781584 0.12395115300394 1.00666996536368 0.56 18.2 18 2 abnormal vertebrae development 0.0305953800781584 0.12395115300394 1.00666996536368 0.56 18.2 18 2 decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 0.0305953800781584 0.12395115300394 1.00666996536368 0.56 18.2 18 2 weight loss 3.4982954911374e-08 1.08099503530488e-06 1.00666996536368 0.56 18.2 18 2 spleen hyperplasia 0.000268285206813375 0.00285807045802257 1.00666996536368 0.56 18.2 18 2 abnormal gait 2.685870797973e-13 2.3861084321278e-11 1.00643726310632 0.559870550161812 18.2 18 2 short maxilla 0.0129537840102039 0.0671302869278797 1.00455511249527 0.558823529411765 18.2 18 2 abnormal oocyte morphology 0.0129537840102039 0.0671302869278797 1.00455511249527 0.558823529411765 18.2 18 2 abnormal spleen red pulp morphology 0.0129537840102039 0.0671302869278797 1.00455511249527 0.558823529411765 18.2 18 2 abnormal axon guidance 0.00563306752037103 0.0357000139029884 1.0033255468741 0.558139534883721 18.2 18 2 cachexia 2.38407124693128e-05 0.000363826823726476 1.0025216001218 0.557692307692308 18.2 18 2 abnormal brain wave pattern 0.00249158460308173 0.0183639013338246 1.0025216001218 0.557692307692308 18.2 18 2 decreased body temperature 0.00249158460308173 0.0183639013338246 1.0025216001218 0.557692307692308 18.2 18 2 hunched posture 0.000228719799499475 0.00252301774392437 1.00120882631108 0.556962025316456 18.2 18 2 abnormal suckling behavior 0.000104458315111216 0.0012768553259909 1.00095024965139 0.556818181818182 18.2 18 2 teratozoospermia 0.000104458315111216 0.0012768553259909 1.00095024965139 0.556818181818182 18.2 18 2 decreased IgM level 4.79029456322e-05 0.00065113976644862 1.00073965628937 0.556701030927835 18.2 18 2 abnormal hair follicle morphology 0.00102673167912839 0.00894569195037432 0.998680521194128 0.555555555555556 18.2 18 2 abnormal ectoderm development 0.00516774049089514 0.0332164198219681 0.998680521194128 0.555555555555556 18.2 18 2 albuminuria 0.00516774049089514 0.0332164198219681 0.998680521194128 0.555555555555556 18.2 18 2 abnormal metabolism 0.00516774049089514 0.0332164198219681 0.998680521194128 0.555555555555556 18.2 18 2 lethality at weaning, complete penetrance 0.00516774049089514 0.0332164198219681 0.998680521194128 0.555555555555556 18.2 18 2 reduced long term depression 0.0118454081700916 0.0630951880580362 0.998680521194128 0.555555555555556 18.2 18 2 short radius 0.0118454081700916 0.0630951880580362 0.998680521194128 0.555555555555556 18.2 18 2 abnormal palate morphology 0.0278263988908499 0.118377301615527 0.998680521194128 0.555555555555556 18.2 18 2 abnormal mitral valve morphology 0.0682401831909299 0.218324701848795 0.998680521194128 0.555555555555556 18.2 18 2 abnormal stomach glandular epithelium morphology 0.0682401831909299 0.218324701848795 0.998680521194128 0.555555555555556 18.2 18 2 abnormal phrenic nerve morphology 0.0682401831909299 0.218324701848795 0.998680521194128 0.555555555555556 18.2 18 2 abnormal thyroid cartilage morphology 0.0682401831909299 0.218324701848795 0.998680521194128 0.555555555555556 18.2 18 2 abnormal thymus cortex morphology 0.0682401831909299 0.218324701848795 0.998680521194128 0.555555555555556 18.2 18 2 absent allantois 0.0682401831909299 0.218324701848795 0.998680521194128 0.555555555555556 18.2 18 2 abnormal redox activity 0.0682401831909299 0.218324701848795 0.998680521194128 0.555555555555556 18.2 18 2 increased circulating glycerol level 0.0682401831909299 0.218324701848795 0.998680521194128 0.555555555555556 18.2 18 2 decreased activity of thyroid 0.0682401831909299 0.218324701848795 0.998680521194128 0.555555555555556 18.2 18 2 decreased pulmonary respiratory rate 0.0682401831909299 0.218324701848795 0.998680521194128 0.555555555555556 18.2 18 2 abnormal pregnancy 0.0682401831909299 0.218324701848795 0.998680521194128 0.555555555555556 18.2 18 2 decreased tumor latency 0.0682401831909299 0.218324701848795 0.998680521194128 0.555555555555556 18.2 18 2 atrioventricular block 0.0682401831909299 0.218324701848795 0.998680521194128 0.555555555555556 18.2 18 2 abnormal head movements 0.184500708660423 0.410322318098168 0.998680521194128 0.555555555555556 18.2 18 2 synostosis 0.184500708660423 0.410322318098168 0.998680521194128 0.555555555555556 18.2 18 2 abnormal geniculate ganglion morphology 0.184500708660423 0.410322318098168 0.998680521194128 0.555555555555556 18.2 18 2 psoriasis 0.184500708660423 0.410322318098168 0.998680521194128 0.555555555555556 18.2 18 2 wavy vibrissae 0.184500708660423 0.410322318098168 0.998680521194128 0.555555555555556 18.2 18 2 abnormal ion homeostasis 0.184500708660423 0.410322318098168 0.998680521194128 0.555555555555556 18.2 18 2 abnormal postural reflex 0.184500708660423 0.410322318098168 0.998680521194128 0.555555555555556 18.2 18 2 genetic imprinting 0.184500708660423 0.410322318098168 0.998680521194128 0.555555555555556 18.2 18 2 abnormal artery development 0.184500708660423 0.410322318098168 0.998680521194128 0.555555555555556 18.2 18 2 priapism 0.184500708660423 0.410322318098168 0.998680521194128 0.555555555555556 18.2 18 2 abnormal bony labyrinth 0.184500708660423 0.410322318098168 0.998680521194128 0.555555555555556 18.2 18 2 abnormal stria vascularis vasculature morphology 0.184500708660423 0.410322318098168 0.998680521194128 0.555555555555556 18.2 18 2 abnormal hair cell mechanoelectric transduction 0.184500708660423 0.410322318098168 0.998680521194128 0.555555555555556 18.2 18 2 abnormal CNS synapse formation 0.184500708660423 0.410322318098168 0.998680521194128 0.555555555555556 18.2 18 2 hemothorax 0.184500708660423 0.410322318098168 0.998680521194128 0.555555555555556 18.2 18 2 abnormal oxygen consumption 0.184500708660423 0.410322318098168 0.998680521194128 0.555555555555556 18.2 18 2 absent adrenal gland 0.184500708660423 0.410322318098168 0.998680521194128 0.555555555555556 18.2 18 2 abnormal leukopoiesis 0.184500708660423 0.410322318098168 0.998680521194128 0.555555555555556 18.2 18 2 enhanced conditioned place preference behavior 0.184500708660423 0.410322318098168 0.998680521194128 0.555555555555556 18.2 18 2 abnormal retinal development 0.184500708660423 0.410322318098168 0.998680521194128 0.555555555555556 18.2 18 2 abnormal liver vasculature morphology 0.184500708660423 0.410322318098168 0.998680521194128 0.555555555555556 18.2 18 2 multiflagellated sperm 0.184500708660423 0.410322318098168 0.998680521194128 0.555555555555556 18.2 18 2 abnormal hippocampus granule cell morphology 0.184500708660423 0.410322318098168 0.998680521194128 0.555555555555556 18.2 18 2 abnormal cerebellar layer morphology 0.184500708660423 0.410322318098168 0.998680521194128 0.555555555555556 18.2 18 2 retropulsion 0.184500708660423 0.410322318098168 0.998680521194128 0.555555555555556 18.2 18 2 shortened ST segment 0.184500708660423 0.410322318098168 0.998680521194128 0.555555555555556 18.2 18 2 abnormal heart left ventricle pressure 0.184500708660423 0.410322318098168 0.998680521194128 0.555555555555556 18.2 18 2 decreased effector memory CD4-positive, alpha-beta T cell number 0.184500708660423 0.410322318098168 0.998680521194128 0.555555555555556 18.2 18 2 abnormal pulmonary alveolar parenchyma morphology 0.184500708660423 0.410322318098168 0.998680521194128 0.555555555555556 18.2 18 2 abnormal oxidative phosphorylation 0.184500708660423 0.410322318098168 0.998680521194128 0.555555555555556 18.2 18 2 adipose tissue inflammation 0.184500708660423 0.410322318098168 0.998680521194128 0.555555555555556 18.2 18 2 increased granulocyte number 0.000427491568929391 0.00423298384762838 0.99598138465036 0.554054054054054 18.2 18 2 abnormal neuron differentiation 1.73752161137574e-05 0.000277056731301099 0.995113805047007 0.553571428571429 18.2 18 2 short mandible 0.00210468081073729 0.0157930422826818 0.995113805047007 0.553571428571429 18.2 18 2 abnormal tibia morphology 0.00473787147184909 0.0307313045273132 0.994430816848621 0.553191489361702 18.2 18 2 increased circulating HDL cholesterol level 3.4792040942257e-05 0.000498819607169246 0.992973775358733 0.552380952380952 18.2 18 2 abnormal blood vessel morphology 1.35855387304374e-06 2.9386110949533e-05 0.991793069323824 0.551724137931034 18.2 18 2 abnormal middle ear morphology 0.0252959477262478 0.110683676286792 0.991793069323824 0.551724137931034 18.2 18 2 abnormal dendritic cell physiology 3.20894111724681e-05 0.000469543589950085 0.99121375094221 0.551401869158878 18.2 18 2 improved glucose tolerance 2.35096220244266e-08 7.6444685994459e-07 0.990528027143564 0.551020408163265 18.2 18 2 cardiac hypertrophy 6.97668300143655e-05 0.000923111647131564 0.990528027143564 0.551020408163265 18.2 18 2 neonatal lethality, complete penetrance 2.24797778830461e-17 3.28932044023983e-15 0.989482147972603 0.550438596491228 18.2 18 2 increased monocyte cell number 6.42847980069161e-05 0.000855125321081304 0.988693715982187 0.55 18.2 18 2 enlarged liver 6.42847980069161e-05 0.000855125321081304 0.988693715982187 0.55 18.2 18 2 decreased circulating phosphate level 0.00988775370857112 0.0546573052223792 0.988693715982187 0.55 18.2 18 2 abnormal pancreatic beta cell morphology 0.00988775370857112 0.0546573052223792 0.988693715982187 0.55 18.2 18 2 increased susceptibility to weight loss 0.00988775370857112 0.0546573052223792 0.988693715982187 0.55 18.2 18 2 decreased paired-pulse facilitation 0.0614101593656572 0.1994226780967 0.988693715982187 0.55 18.2 18 2 abnormal hyoid bone morphology 0.0614101593656572 0.1994226780967 0.988693715982187 0.55 18.2 18 2 decreased circulating VLDL cholesterol level 0.0614101593656572 0.1994226780967 0.988693715982187 0.55 18.2 18 2 abnormal induced retinal neovascularization 0.0614101593656572 0.1994226780967 0.988693715982187 0.55 18.2 18 2 increased thermal nociceptive threshold 0.000140130067538068 0.00164810185816049 0.987706009972215 0.549450549450549 18.2 18 2 abnormal locomotor activation 0.000140130067538068 0.00164810185816049 0.987706009972215 0.549450549450549 18.2 18 2 atelectasis 0.000734264329307154 0.0067273757611475 0.987427782927152 0.549295774647887 18.2 18 2 impaired hematopoiesis 0.0039763884190024 0.0266610948578665 0.986931338591844 0.549019607843137 18.2 18 2 decreased neuronal precursor cell number 0.0229885886359497 0.105700765678234 0.985794320920656 0.548387096774194 18.2 18 2 abnormal cartilage morphology 0.00902802486947463 0.0504656446355464 0.984413656605641 0.547619047619048 18.2 18 2 hyperactivity 5.44942153699796e-14 5.42217442931297e-12 0.983606098232708 0.547169811320755 18.2 18 2 abnormal placenta development 0.00364062134604102 0.0255459678371708 0.983606098232708 0.547169811320755 18.2 18 2 abnormal limb morphology 0.000619475711481059 0.00581488993324201 0.982701632855022 0.546666666666667 18.2 18 2 abnormal spatial learning 6.57453262232204e-07 1.55015638843849e-05 0.981525272977297 0.54601226993865 18.2 18 2 deafness 0.000100388534688129 0.00123928774211773 0.980522693536053 0.545454545454545 18.2 18 2 abnormal circadian rhythm 0.00824047913489925 0.04621914734625 0.980522693536053 0.545454545454545 18.2 18 2 single kidney 0.0208878945642515 0.0969377569562976 0.980522693536053 0.545454545454545 18.2 18 2 abnormal middle ear ossicle morphology 0.0208878945642515 0.0969377569562976 0.980522693536053 0.545454545454545 18.2 18 2 abnormal basisphenoid bone morphology 0.0552916095617945 0.196390404530111 0.980522693536053 0.545454545454545 18.2 18 2 abnormal long bone epiphysis morphology 0.0552916095617945 0.196390404530111 0.980522693536053 0.545454545454545 18.2 18 2 intestinal inflammation 0.0552916095617945 0.196390404530111 0.980522693536053 0.545454545454545 18.2 18 2 testis hypoplasia 0.0552916095617945 0.196390404530111 0.980522693536053 0.545454545454545 18.2 18 2 parakeratosis 0.0552916095617945 0.196390404530111 0.980522693536053 0.545454545454545 18.2 18 2 abnormal mesenteric lymph node morphology 0.0552916095617945 0.196390404530111 0.980522693536053 0.545454545454545 18.2 18 2 failure of palatal shelf elevation 0.0552916095617945 0.196390404530111 0.980522693536053 0.545454545454545 18.2 18 2 abnormal cerebral cortex pyramidal cell morphology 0.0552916095617945 0.196390404530111 0.980522693536053 0.545454545454545 18.2 18 2 increased circulating creatine kinase level 0.0552916095617945 0.196390404530111 0.980522693536053 0.545454545454545 18.2 18 2 abnormal thrombopoiesis 0.161532505017268 0.369142954736292 0.980522693536053 0.545454545454545 18.2 18 2 decreased atrioventricular cushion size 0.161532505017268 0.369142954736292 0.980522693536053 0.545454545454545 18.2 18 2 abnormal awl hair morphology 0.161532505017268 0.369142954736292 0.980522693536053 0.545454545454545 18.2 18 2 abnormal enteric ganglia morphology 0.161532505017268 0.369142954736292 0.980522693536053 0.545454545454545 18.2 18 2 social withdrawal 0.161532505017268 0.369142954736292 0.980522693536053 0.545454545454545 18.2 18 2 abnormal primary sex determination 0.161532505017268 0.369142954736292 0.980522693536053 0.545454545454545 18.2 18 2 patent ductus arteriosus 0.161532505017268 0.369142954736292 0.980522693536053 0.545454545454545 18.2 18 2 abnormal hair medulla 0.161532505017268 0.369142954736292 0.980522693536053 0.545454545454545 18.2 18 2 abnormal pituitary gland development 0.161532505017268 0.369142954736292 0.980522693536053 0.545454545454545 18.2 18 2 abnormal crista ampullaris neuroepithelium morphology 0.161532505017268 0.369142954736292 0.980522693536053 0.545454545454545 18.2 18 2 abnormal spinal cord ventral horn morphology 0.161532505017268 0.369142954736292 0.980522693536053 0.545454545454545 18.2 18 2 abnormal Bruch membrane morphology 0.161532505017268 0.369142954736292 0.980522693536053 0.545454545454545 18.2 18 2 increased circulating triiodothyronine level 0.161532505017268 0.369142954736292 0.980522693536053 0.545454545454545 18.2 18 2 aberrant origin of the right subclavian artery 0.161532505017268 0.369142954736292 0.980522693536053 0.545454545454545 18.2 18 2 abnormal extraembryonic ectoderm morphology 0.161532505017268 0.369142954736292 0.980522693536053 0.545454545454545 18.2 18 2 decreased core body temperature 0.161532505017268 0.369142954736292 0.980522693536053 0.545454545454545 18.2 18 2 abnormal brain ependyma motile cilium morphology 0.161532505017268 0.369142954736292 0.980522693536053 0.545454545454545 18.2 18 2 chylous ascites 0.161532505017268 0.369142954736292 0.980522693536053 0.545454545454545 18.2 18 2 no abnormal phenotype detected 2.48886932388302e-60 3.0955312215795e-57 0.980145931694157 0.545244956772334 18.2 18 2 decreased circulating alanine transaminase level 0.00125489696538353 0.0106356258991193 0.978119451640132 0.544117647058823 18.2 18 2 delayed wound healing 0.00751978430246852 0.0423200530597069 0.976970075081212 0.543478260869565 18.2 18 2 decreased circulating thyroxine level 0.018977410374924 0.0889007689409105 0.975853537852548 0.542857142857143 18.2 18 2 decreased bone volume 0.018977410374924 0.0889007689409105 0.975853537852548 0.542857142857143 18.2 18 2 decreased bone mineralization 0.018977410374924 0.0889007689409105 0.975853537852548 0.542857142857143 18.2 18 2 abnormal colon morphology 0.00278904819359442 0.0204051687693121 0.974983017301386 0.542372881355932 18.2 18 2 abnormal lipid level 0.000439432193649444 0.0043290597295168 0.974615930321981 0.542168674698795 18.2 18 2 increased T cell proliferation 7.16361107346948e-05 0.000940342086820861 0.974413517875392 0.542056074766355 18.2 18 2 abnormal digit morphology 0.00105366551358548 0.00908529625475865 0.973713508164275 0.541666666666667 18.2 18 2 abnormal intestinal epithelium morphology 0.00686079823186098 0.0407308725578859 0.973713508164275 0.541666666666667 18.2 18 2 oligodactyly 0.00686079823186098 0.0407308725578859 0.973713508164275 0.541666666666667 18.2 18 2 decreased metastatic potential 0.0498109456446399 0.180619135992772 0.973713508164275 0.541666666666667 18.2 18 2 abnormal startle reflex 0.0498109456446399 0.180619135992772 0.973713508164275 0.541666666666667 18.2 18 2 increased body temperature 0.0498109456446399 0.180619135992772 0.973713508164275 0.541666666666667 18.2 18 2 increased osteoclast cell number 0.00255083381821338 0.0187727784698396 0.972485622277561 0.540983606557377 18.2 18 2 increased brown adipose tissue amount 0.0172412057888577 0.0816127486199495 0.971689155756449 0.540540540540541 18.2 18 2 skin inflammation 0.0172412057888577 0.0816127486199495 0.971689155756449 0.540540540540541 18.2 18 2 abnormal humerus morphology 0.0172412057888577 0.0816127486199495 0.971689155756449 0.540540540540541 18.2 18 2 increased circulating chloride level 0.0062586273828238 0.0380179135891922 0.970717466600693 0.54 18.2 18 2 increased circulating glucose level 7.81790856964368e-06 0.000137922323170132 0.96893259077558 0.539007092198582 18.2 18 2 absent corpus luteum 0.0057086595375765 0.0357762327589088 0.967951889772771 0.538461538461538 18.2 18 2 increased leukemia incidence 0.0449000145380486 0.168539609394208 0.967951889772771 0.538461538461538 18.2 18 2 pulmonary edema 0.0449000145380486 0.168539609394208 0.967951889772771 0.538461538461538 18.2 18 2 absent common myeloid progenitor cells 0.142189038005358 0.332420330863091 0.967951889772771 0.538461538461538 18.2 18 2 absent myocardial trabeculae 0.142189038005358 0.332420330863091 0.967951889772771 0.538461538461538 18.2 18 2 tight skin 0.142189038005358 0.332420330863091 0.967951889772771 0.538461538461538 18.2 18 2 pup cannibalization 0.142189038005358 0.332420330863091 0.967951889772771 0.538461538461538 18.2 18 2 abnormal digestion 0.142189038005358 0.332420330863091 0.967951889772771 0.538461538461538 18.2 18 2 abnormal pulmonary alveolus epithelial cell morphology 0.142189038005358 0.332420330863091 0.967951889772771 0.538461538461538 18.2 18 2 absent lateral semicircular canal 0.142189038005358 0.332420330863091 0.967951889772771 0.538461538461538 18.2 18 2 tracheoesophageal fistula 0.142189038005358 0.332420330863091 0.967951889772771 0.538461538461538 18.2 18 2 abnormal insulin secretion 0.142189038005358 0.332420330863091 0.967951889772771 0.538461538461538 18.2 18 2 abnormal vestibulocochlear ganglion morphology 0.142189038005358 0.332420330863091 0.967951889772771 0.538461538461538 18.2 18 2 small otic vesicle 0.142189038005358 0.332420330863091 0.967951889772771 0.538461538461538 18.2 18 2 small interparietal bone 0.142189038005358 0.332420330863091 0.967951889772771 0.538461538461538 18.2 18 2 decreased endocochlear potential 0.142189038005358 0.332420330863091 0.967951889772771 0.538461538461538 18.2 18 2 increased circulating ammonia level 0.142189038005358 0.332420330863091 0.967951889772771 0.538461538461538 18.2 18 2 hyperalgesia 0.142189038005358 0.332420330863091 0.967951889772771 0.538461538461538 18.2 18 2 increased renin activity 0.142189038005358 0.332420330863091 0.967951889772771 0.538461538461538 18.2 18 2 orthokeratosis 0.142189038005358 0.332420330863091 0.967951889772771 0.538461538461538 18.2 18 2 empty decidua capsularis 0.142189038005358 0.332420330863091 0.967951889772771 0.538461538461538 18.2 18 2 acanthosis 0.0156641798565489 0.076551370124097 0.96795188977277 0.538461538461538 18.2 18 2 increased vascular permeability 0.0156641798565489 0.076551370124097 0.96795188977277 0.538461538461538 18.2 18 2 increased autoantibody level 0.0156641798565489 0.076551370124097 0.96795188977277 0.538461538461538 18.2 18 2 increased total body fat amount 1.54317512672257e-05 0.000249262865436519 0.965888026468351 0.537313432835821 18.2 18 2 abnormal femur morphology 0.0019495808584249 0.0151549449541623 0.965888026468351 0.537313432835821 18.2 18 2 increased inflammatory response 0.000260984050507339 0.00281647646697183 0.965040756269694 0.536842105263158 18.2 18 2 sparse hair 0.000678515939774753 0.00625114222292481 0.964579235104573 0.536585365853659 18.2 18 2 short ulna 0.0142322130417307 0.071433582118386 0.964579235104573 0.536585365853659 18.2 18 2 hemopericardium 0.0142322130417307 0.071433582118386 0.964579235104573 0.536585365853659 18.2 18 2 abnormal cholesterol homeostasis 0.0142322130417307 0.071433582118386 0.964579235104573 0.536585365853659 18.2 18 2 abnormal seminal vesicle morphology 0.00474836902750989 0.0307592915519032 0.96301335972291 0.535714285714286 18.2 18 2 abnormal stria vascularis morphology 0.0404970960558121 0.160153460157127 0.96301335972291 0.535714285714286 18.2 18 2 myoclonus 0.0404970960558121 0.160153460157127 0.96301335972291 0.535714285714286 18.2 18 2 increased triglyceride level 0.0404970960558121 0.160153460157127 0.96301335972291 0.535714285714286 18.2 18 2 abnormal spermiogenesis 0.00433030825705692 0.028234971925109 0.960799535907454 0.53448275862069 18.2 18 2 female infertility 2.84831686559279e-09 1.12829873705598e-07 0.959634365478268 0.533834586466165 18.2 18 2 abnormal neurocranium morphology 0.00136029913382825 0.0113358261152354 0.958733300346363 0.533333333333333 18.2 18 2 abnormal autopod morphology 0.0117521804423325 0.0627329374470002 0.958733300346363 0.533333333333333 18.2 18 2 abnormal cell migration 0.0117521804423325 0.0627329374470002 0.958733300346363 0.533333333333333 18.2 18 2 abnormal lactation 0.0365469373689706 0.146804789229255 0.958733300346363 0.533333333333333 18.2 18 2 abnormal microglial cell physiology 0.0365469373689706 0.146804789229255 0.958733300346363 0.533333333333333 18.2 18 2 abnormal enteric neuron morphology 0.125686872116996 0.316122954191448 0.958733300346363 0.533333333333333 18.2 18 2 no suckling reflex 0.125686872116996 0.316122954191448 0.958733300346363 0.533333333333333 18.2 18 2 abnormal apical ectodermal ridge morphology 0.125686872116996 0.316122954191448 0.958733300346363 0.533333333333333 18.2 18 2 abnormal respiratory system morphology 0.125686872116996 0.316122954191448 0.958733300346363 0.533333333333333 18.2 18 2 abnormal olfactory nerve morphology 0.125686872116996 0.316122954191448 0.958733300346363 0.533333333333333 18.2 18 2 abnormal dendritic cell morphology 0.125686872116996 0.316122954191448 0.958733300346363 0.533333333333333 18.2 18 2 abnormal Muller cell morphology 0.125686872116996 0.316122954191448 0.958733300346363 0.533333333333333 18.2 18 2 absent chorion 0.125686872116996 0.316122954191448 0.958733300346363 0.533333333333333 18.2 18 2 abnormal secondary palate development 0.125686872116996 0.316122954191448 0.958733300346363 0.533333333333333 18.2 18 2 abnormal aorta wall morphology 0.125686872116996 0.316122954191448 0.958733300346363 0.533333333333333 18.2 18 2 ostium primum atrial septal defect 0.125686872116996 0.316122954191448 0.958733300346363 0.533333333333333 18.2 18 2 decreased trabecular bone mass 0.125686872116996 0.316122954191448 0.958733300346363 0.533333333333333 18.2 18 2 abnormal auditory brainstem response waveform shape 0.0330003702188988 0.1335857134573 0.954988248391885 0.53125 18.2 18 2 increased spleen weight 0.000118515777233325 0.00143458878767832 0.954491117601468 0.530973451327434 18.2 18 2 organ of Corti degeneration 0.00970876158420091 0.0538473677607576 0.953841803916025 0.530612244897959 18.2 18 2 abnormal respiratory system physiology 0.00970876158420091 0.0538473677607576 0.953841803916025 0.530612244897959 18.2 18 2 decreased neutrophil cell number 9.93672789439063e-05 0.00122973187250232 0.952587574062091 0.52991452991453 18.2 18 2 abnormal retinal photoreceptor morphology 0.0298137689375551 0.121278414116383 0.951683790784993 0.529411764705882 18.2 18 2 overexpanded pulmonary alveoli 0.0298137689375551 0.121278414116383 0.951683790784993 0.529411764705882 18.2 18 2 abnormal endoderm development 0.0298137689375551 0.121278414116383 0.951683790784993 0.529411764705882 18.2 18 2 absence seizures 0.111473438495104 0.316122954191448 0.951683790784993 0.529411764705882 18.2 18 2 abnormal testis development 0.111473438495104 0.316122954191448 0.951683790784993 0.529411764705882 18.2 18 2 common atrium 0.111473438495104 0.316122954191448 0.951683790784993 0.529411764705882 18.2 18 2 increased trabecular bone mass 0.111473438495104 0.316122954191448 0.951683790784993 0.529411764705882 18.2 18 2 decreased body fat mass 0.111473438495104 0.316122954191448 0.951683790784993 0.529411764705882 18.2 18 2 decreased B cell number 3.33560026842258e-07 8.42366057634636e-06 0.95117047698198 0.529126213592233 18.2 18 2 abnormal epidermis stratum granulosum morphology 0.0269484716626779 0.116581431758107 0.948746495134422 0.527777777777778 18.2 18 2 abnormal limb bone morphology 0.0269484716626779 0.116581431758107 0.948746495134422 0.527777777777778 18.2 18 2 increased sensitivity to xenobiotic induced morbidity/mortality 0.000195487937796315 0.00217573264102162 0.947838603751518 0.527272727272727 18.2 18 2 increased circulating calcium level 0.00729733541183658 0.0418782651840179 0.947838603751518 0.527272727272727 18.2 18 2 abnormal platelet physiology 0.00729733541183658 0.0418782651840179 0.947838603751518 0.527272727272727 18.2 18 2 abnormal spermatogenesis 1.78116466656305e-06 3.72323286392906e-05 0.947660972828776 0.527173913043478 18.2 18 2 seizures 0.000163541740428157 0.00185334888070634 0.946118388499701 0.526315789473684 18.2 18 2 increased macrophage cell number 0.00663669297327234 0.0396845523341706 0.946118388499701 0.526315789473684 18.2 18 2 hyporesponsive to tactile stimuli 0.0243702213627925 0.108373450809571 0.9461183884997 0.526315789473684 18.2 18 2 abnormal nail morphology 0.0991407526783766 0.300015355580854 0.9461183884997 0.526315789473684 18.2 18 2 shiny skin 0.0991407526783766 0.300015355580854 0.9461183884997 0.526315789473684 18.2 18 2 thin dermal layer 0.0991407526783766 0.300015355580854 0.9461183884997 0.526315789473684 18.2 18 2 delayed sexual maturation 0.0991407526783766 0.300015355580854 0.9461183884997 0.526315789473684 18.2 18 2 abnormal ear morphology 0.0991407526783766 0.300015355580854 0.9461183884997 0.526315789473684 18.2 18 2 abnormal neurotransmitter level 0.0991407526783766 0.300015355580854 0.9461183884997 0.526315789473684 18.2 18 2 osteoarthritis 0.0991407526783766 0.300015355580854 0.9461183884997 0.526315789473684 18.2 18 2 abnormal cochlear inner hair cell morphology 0.0991407526783766 0.300015355580854 0.9461183884997 0.526315789473684 18.2 18 2 eyelids fail to open 0.0991407526783766 0.300015355580854 0.9461183884997 0.526315789473684 18.2 18 2 decreased susceptibility to weight gain 0.0991407526783766 0.300015355580854 0.9461183884997 0.526315789473684 18.2 18 2 decreased liver glycogen level 0.0991407526783766 0.300015355580854 0.9461183884997 0.526315789473684 18.2 18 2 increased circulating insulin level 1.04126314588516e-05 0.000178630487957885 0.943753092528451 0.525 18.2 18 2 arrest of spermatogenesis 0.00130812668761725 0.011049117607633 0.941613062840178 0.523809523809524 18.2 18 2 decreased exploration in new environment 0.00130812668761725 0.011049117607633 0.941613062840178 0.523809523809524 18.2 18 2 abnormal vibrissa morphology 0.0199568200312126 0.0929636513626241 0.941613062840178 0.523809523809524 18.2 18 2 abnormal anxiety-related response 0.0883771171627848 0.273770957587082 0.941613062840178 0.523809523809524 18.2 18 2 abnormal clavicle morphology 0.0883771171627848 0.273770957587082 0.941613062840178 0.523809523809524 18.2 18 2 abnormal bile salt homeostasis 0.0883771171627848 0.273770957587082 0.941613062840178 0.523809523809524 18.2 18 2 abnormal tumor vascularization 0.0883771171627848 0.273770957587082 0.941613062840178 0.523809523809524 18.2 18 2 abnormal myelopoiesis 0.0180708055247067 0.085296259473829 0.939667581305384 0.522727272727273 18.2 18 2 decreased insulin secretion 0.000993315701177805 0.00880881571008837 0.938759689922481 0.522222222222222 18.2 18 2 increased bone mineral density 0.000244675787308772 0.0026753011909036 0.93858293230811 0.52212389380531 18.2 18 2 abnormal carpal bone morphology 0.0789380566496358 0.248240728085928 0.937891272077964 0.521739130434783 18.2 18 2 hypotension 0.0789380566496358 0.248240728085928 0.937891272077964 0.521739130434783 18.2 18 2 abnormal postnatal growth 0.0789380566496358 0.248240728085928 0.937891272077964 0.521739130434783 18.2 18 2 abnormal corneal stroma morphology 0.0789380566496358 0.248240728085928 0.937891272077964 0.521739130434783 18.2 18 2 abnormal CD4-positive, alpha-beta T cell physiology 0.00342867790407831 0.0243333417586157 0.93679046072576 0.52112676056338 18.2 18 2 abnormal cardiovascular system morphology 0.014833495242345 0.0730659790402638 0.936262988619495 0.520833333333333 18.2 18 2 kidney inflammation 0.0134464069690261 0.0691073085443231 0.934764967837704 0.52 18.2 18 2 abnormal skin condition 0.012193031831033 0.0647388829876086 0.933382179423743 0.519230769230769 18.2 18 2 increased susceptibility to injury 0.012193031831033 0.0647388829876086 0.933382179423743 0.519230769230769 18.2 18 2 abnormal response to infection 0.00235746359491652 0.0176366637364055 0.932944588153502 0.518987341772152 18.2 18 2 abnormal cardiovascular system physiology 9.9314113394762e-05 0.00122973187250232 0.932602411521133 0.518796992481203 18.2 18 2 abnormal cochlea morphology 0.0110599367909557 0.0593561872006524 0.932101819781186 0.518518518518518 18.2 18 2 abnormal mandible morphology 0.0110599367909557 0.0593561872006524 0.932101819781186 0.518518518518518 18.2 18 2 abnormal heart valve morphology 0.0632869852350317 0.204317165181235 0.932101819781186 0.518518518518518 18.2 18 2 abnormal atrioventricular cushion morphology 0.0632869852350317 0.204317165181235 0.932101819781186 0.518518518518518 18.2 18 2 abnormal brain commissure morphology 0.0632869852350317 0.204317165181235 0.932101819781186 0.518518518518518 18.2 18 2 abnormal type II pneumocyte morphology 0.0632869852350317 0.204317165181235 0.932101819781186 0.518518518518518 18.2 18 2 abnormal bone trabecula morphology 0.0632869852350317 0.204317165181235 0.932101819781186 0.518518518518518 18.2 18 2 decreased bone ossification 0.0632869852350317 0.204317165181235 0.932101819781186 0.518518518518518 18.2 18 2 cochlear ganglion degeneration 0.00910781945493171 0.0507975356370911 0.929806002491085 0.517241379310345 18.2 18 2 abnormal enzyme/coenzyme level 0.00910781945493171 0.0507975356370911 0.929806002491085 0.517241379310345 18.2 18 2 short sternum 0.0567840406946313 0.196390404530111 0.929806002491085 0.517241379310345 18.2 18 2 abnormal B cell differentiation 0.0013485603847053 0.0112725077074113 0.928443649373882 0.516483516483517 18.2 18 2 impaired righting response 0.00112036182552673 0.00957697608590285 0.927196020729706 0.515789473684211 18.2 18 2 decreased T cell number 2.81957583394159e-05 0.000415011531770989 0.926725899791322 0.515527950310559 18.2 18 2 dextrocardia 0.0458698756019614 0.168539609394208 0.926049210561828 0.515151515151515 18.2 18 2 absent vibrissae 0.0458698756019614 0.168539609394208 0.926049210561828 0.515151515151515 18.2 18 2 abnormal skeleton physiology 0.0458698756019614 0.168539609394208 0.926049210561828 0.515151515151515 18.2 18 2 dilated heart atrium 0.0458698756019614 0.168539609394208 0.926049210561828 0.515151515151515 18.2 18 2 abnormal QRS complex 0.0458698756019614 0.168539609394208 0.926049210561828 0.515151515151515 18.2 18 2 diarrhea 0.0458698756019614 0.168539609394208 0.926049210561828 0.515151515151515 18.2 18 2 abnormal motor coordination/ balance 0.000931115902278014 0.00836155525962657 0.926049210561828 0.515151515151515 18.2 18 2 lung inflammation 0.000122068816381977 0.00147401058616586 0.925248129929854 0.514705882352941 18.2 18 2 thick epidermis 0.00511720485616093 0.0330624599472735 0.924492825333993 0.514285714285714 18.2 18 2 abnormal intestine morphology 0.00422984074588506 0.027616086234617 0.923104697968627 0.513513513513513 18.2 18 2 abnormal hair follicle development 0.0371950300850438 0.148869891128795 0.923104697968627 0.513513513513513 18.2 18 2 increased trabecular bone volume 0.0371950300850438 0.148869891128795 0.923104697968627 0.513513513513513 18.2 18 2 increased B cell number 0.000406573119330476 0.00404540253733824 0.921858942640734 0.512820512820513 18.2 18 2 abnormal excitatory postsynaptic currents 0.00349896046447206 0.0247044472140444 0.921858942640734 0.512820512820513 18.2 18 2 small lens 0.0335344755798906 0.135525207587589 0.921858942640734 0.512820512820513 18.2 18 2 decreased B-1 B cell number 0.0335344755798906 0.135525207587589 0.921858942640734 0.512820512820513 18.2 18 2 short humerus 0.0302559105737101 0.122976433908667 0.920734724418001 0.51219512195122 18.2 18 2 abnormal male reproductive system morphology 0.0273159187276847 0.118068371564059 0.919715084634593 0.511627906976744 18.2 18 2 abnormal cartilage development 0.0246766408380978 0.108738962063363 0.918786079498598 0.511111111111111 18.2 18 2 absent kidney 0.0201717594695784 0.0937892554777126 0.917155580688485 0.510204081632653 18.2 18 2 abnormal epidermis stratum corneum morphology 0.0201717594695784 0.0937892554777126 0.917155580688485 0.510204081632653 18.2 18 2 abnormal response to novel object 0.0182514781510055 0.0860673969680115 0.916436242978141 0.509803921568627 18.2 18 2 abnormal coat/ hair morphology 0.0165215155622368 0.0786550621264382 0.915771194906314 0.509433962264151 18.2 18 2 abnormal contextual conditioning behavior 0.0149618937767088 0.0734801792094042 0.915154513966983 0.509090909090909 18.2 18 2 abnormal joint morphology 0.0149618937767088 0.0734801792094042 0.915154513966983 0.509090909090909 18.2 18 2 abnormal T-helper 2 physiology 0.0149618937767088 0.0734801792094042 0.915154513966983 0.509090909090909 18.2 18 2 increased hemoglobin content 0.012284836138669 0.0649258586460707 0.91404657872005 0.508474576271186 18.2 18 2 maternal effect 0.00831590189415801 0.0465896530669326 0.912227580553443 0.507462686567164 18.2 18 2 abnormal epidermal layer morphology 0.00754862621052016 0.0424343676806077 0.911838736742465 0.507246376811594 18.2 18 2 decreased food intake 0.00466972648452905 0.0303684826935059 0.910189842100978 0.506329113924051 18.2 18 2 increased sensitivity to induced morbidity/mortality 2.6651570114939e-05 0.000394617742029231 0.908582169825528 0.505434782608696 18.2 18 2 abnormal trabecular bone morphology 0.000714251751092154 0.00655609310273703 0.906365515033327 0.504201680672269 18.2 18 2 abnormal lung morphology 0.000714251751092154 0.00655609310273703 0.906365515033327 0.504201680672269 18.2 18 2 increased anxiety-related response 0.000284042493895852 0.00299128660039844 0.905278745830649 0.503597122302158 18.2 18 2 abnormal spleen white pulp morphology 0.0405550011162077 0.160255067953243 0.898812469074716 0.5 18.2 18 2 increased susceptibility to weight gain 0.0619259822663681 0.200704730798164 0.898812469074716 0.5 18.2 18 2 abnormal skin physiology 0.0619259822663681 0.200704730798164 0.898812469074716 0.5 18.2 18 2 abnormal respiration 0.0860768744142509 0.267645281381811 0.898812469074716 0.5 18.2 18 2 abnormal Schwann cell morphology 0.096355602145275 0.293551206780614 0.898812469074716 0.5 18.2 18 2 absent atrioventricular cushions 0.200045577012219 0.441734019367859 0.898812469074716 0.5 18.2 18 2 megacephaly 0.200045577012219 0.441734019367859 0.898812469074716 0.5 18.2 18 2 extended life span 0.200045577012219 0.441734019367859 0.898812469074716 0.5 18.2 18 2 abnormal spleen periarteriolar lymphoid sheath morphology 0.200045577012219 0.441734019367859 0.898812469074716 0.5 18.2 18 2 abnormal endplate potential 0.200045577012219 0.441734019367859 0.898812469074716 0.5 18.2 18 2 abnormal prepulse inhibition 0.200045577012219 0.441734019367859 0.898812469074716 0.5 18.2 18 2 abnormal voluntary movement 0.200045577012219 0.441734019367859 0.898812469074716 0.5 18.2 18 2 abnormal decidualization 0.200045577012219 0.441734019367859 0.898812469074716 0.5 18.2 18 2 abnormal pancreas development 0.200045577012219 0.441734019367859 0.898812469074716 0.5 18.2 18 2 decreased cornea thickness 0.200045577012219 0.441734019367859 0.898812469074716 0.5 18.2 18 2 pulmonary alveolar hemorrhage 0.200045577012219 0.441734019367859 0.898812469074716 0.5 18.2 18 2 increased liver weight 0.00420064898489968 0.0274615357422811 0.898812469074715 0.5 18.2 18 2 abnormal skin morphology 0.0121317346169984 0.0645512082562212 0.898812469074715 0.5 18.2 18 2 abnormal osteoclast physiology 0.013382331906816 0.0688491222713647 0.898812469074715 0.5 18.2 18 2 dermatitis 0.0180019954499263 0.0850521627382558 0.898812469074715 0.5 18.2 18 2 abnormal osteoclast morphology 0.0297764004614625 0.121278414116383 0.898812469074715 0.5 18.2 18 2 abnormal photoreceptor outer segment morphology 0.0365610319306627 0.146804789229255 0.898812469074715 0.5 18.2 18 2 cochlear hair cell degeneration 0.0365610319306627 0.146804789229255 0.898812469074715 0.5 18.2 18 2 decreased sensitivity to induced morbidity/mortality 0.0365610319306627 0.146804789229255 0.898812469074715 0.5 18.2 18 2 abnormal female reproductive system morphology 0.0450203002975731 0.168539609394208 0.898812469074715 0.5 18.2 18 2 abnormal uterus morphology 0.0556266490509448 0.196390404530111 0.898812469074715 0.5 18.2 18 2 impaired wound healing 0.0556266490509448 0.196390404530111 0.898812469074715 0.5 18.2 18 2 abnormal lumbar vertebrae morphology 0.0690179818161539 0.220529518006015 0.898812469074715 0.5 18.2 18 2 curly vibrissae 0.108065167654631 0.316122954191448 0.898812469074715 0.5 18.2 18 2 apnea 0.108065167654631 0.316122954191448 0.898812469074715 0.5 18.2 18 2 abnormal retinal layer morphology 0.121462624763775 0.316122954191448 0.898812469074715 0.5 18.2 18 2 abnormal retinal outer plexiform layer morphology 0.121462624763775 0.316122954191448 0.898812469074715 0.5 18.2 18 2 abnormal blood-brain barrier function 0.121462624763775 0.316122954191448 0.898812469074715 0.5 18.2 18 2 decreased circulating estradiol level 0.121462624763775 0.316122954191448 0.898812469074715 0.5 18.2 18 2 abnormal inner cell mass apoptosis 0.108065167654631 0.316122954191448 0.898812469074715 0.5 18.2 18 2 impaired humoral immune response 0.121462624763775 0.316122954191448 0.898812469074715 0.5 18.2 18 2 abnormal dopamine level 0.136871345991096 0.323024168076708 0.898812469074715 0.5 18.2 18 2 abnormal fibula morphology 0.136871345991096 0.323024168076708 0.898812469074715 0.5 18.2 18 2 abnormal heart right ventricle morphology 0.136871345991096 0.323024168076708 0.898812469074715 0.5 18.2 18 2 abnormal megakaryocyte differentiation 0.154706693799278 0.358484304448724 0.898812469074715 0.5 18.2 18 2 abnormal heart shape 0.154706693799278 0.358484304448724 0.898812469074715 0.5 18.2 18 2 underdeveloped hair follicles 0.154706693799278 0.358484304448724 0.898812469074715 0.5 18.2 18 2 right pulmonary isomerism 0.154706693799278 0.358484304448724 0.898812469074715 0.5 18.2 18 2 abnormal radius morphology 0.154706693799278 0.358484304448724 0.898812469074715 0.5 18.2 18 2 abnormal retinal rod cell morphology 0.154706693799278 0.358484304448724 0.898812469074715 0.5 18.2 18 2 blepharoptosis 0.154706693799278 0.358484304448724 0.898812469074715 0.5 18.2 18 2 abnormal thymus medulla morphology 0.154706693799278 0.358484304448724 0.898812469074715 0.5 18.2 18 2 increased circulating renin level 0.154706693799278 0.358484304448724 0.898812469074715 0.5 18.2 18 2 abnormal neutrophil morphology 0.154706693799278 0.358484304448724 0.898812469074715 0.5 18.2 18 2 jerky movement 0.154706693799278 0.358484304448724 0.898812469074715 0.5 18.2 18 2 decreased fluid intake 0.154706693799278 0.358484304448724 0.898812469074715 0.5 18.2 18 2 abnormal tympanic ring morphology 0.175516184281089 0.397447891123541 0.898812469074715 0.5 18.2 18 2 failure of tooth eruption 0.175516184281089 0.397447891123541 0.898812469074715 0.5 18.2 18 2 reduced male mating frequency 0.175516184281089 0.397447891123541 0.898812469074715 0.5 18.2 18 2 abnormal meiosis 0.175516184281089 0.397447891123541 0.898812469074715 0.5 18.2 18 2 decreased cochlear coiling 0.175516184281089 0.397447891123541 0.898812469074715 0.5 18.2 18 2 impaired muscle relaxation 0.175516184281089 0.397447891123541 0.898812469074715 0.5 18.2 18 2 abnormal pulmonary elastic fiber morphology 0.175516184281089 0.397447891123541 0.898812469074715 0.5 18.2 18 2 abnormal molar crown morphology 0.175516184281089 0.397447891123541 0.898812469074715 0.5 18.2 18 2 increased thymus weight 0.175516184281089 0.397447891123541 0.898812469074715 0.5 18.2 18 2 abnormal level of surface class II molecules 0.175516184281089 0.397447891123541 0.898812469074715 0.5 18.2 18 2 decreased circulating prolactin level 0.175516184281089 0.397447891123541 0.898812469074715 0.5 18.2 18 2 loose skin 0.175516184281089 0.397447891123541 0.898812469074715 0.5 18.2 18 2 abnormal thoracic cage shape 0.175516184281089 0.397447891123541 0.898812469074715 0.5 18.2 18 2 abnormal esophagus morphology 0.229354636252575 0.489926713334719 0.898812469074715 0.5 18.2 18 2 abnormal aorta elastic fiber morphology 0.229354636252575 0.489926713334719 0.898812469074715 0.5 18.2 18 2 abnormal alisphenoid bone morphology 0.229354636252575 0.489926713334719 0.898812469074715 0.5 18.2 18 2 vestibular saccular macula degeneration 0.229354636252575 0.489926713334719 0.898812469074715 0.5 18.2 18 2 small parietal bone 0.229354636252575 0.489926713334719 0.898812469074715 0.5 18.2 18 2 abnormal somatic nervous system physiology 0.229354636252575 0.489926713334719 0.898812469074715 0.5 18.2 18 2 abnormal thymus corticomedullary boundary morphology 0.229354636252575 0.489926713334719 0.898812469074715 0.5 18.2 18 2 decreased keratinocyte proliferation 0.229354636252575 0.489926713334719 0.898812469074715 0.5 18.2 18 2 abnormal behavioral response to addictive substance 0.229354636252575 0.489926713334719 0.898812469074715 0.5 18.2 18 2 increased type II pneumocyte number 0.229354636252575 0.489926713334719 0.898812469074715 0.5 18.2 18 2 abnormal lateral semicircular canal morphology 0.2650366534861 0.540098068338575 0.898812469074715 0.5 18.2 18 2 abnormal otic capsule morphology 0.2650366534861 0.540098068338575 0.898812469074715 0.5 18.2 18 2 kidney hemorrhage 0.2650366534861 0.540098068338575 0.898812469074715 0.5 18.2 18 2 abnormal prostate gland epithelium morphology 0.2650366534861 0.540098068338575 0.898812469074715 0.5 18.2 18 2 abnormal epidermis suprabasal layer morphology 0.2650366534861 0.540098068338575 0.898812469074715 0.5 18.2 18 2 abnormal immune cell physiology 0.2650366534861 0.540098068338575 0.898812469074715 0.5 18.2 18 2 decreased incidence of induced tumors 0.2650366534861 0.540098068338575 0.898812469074715 0.5 18.2 18 2 decreased circulating parathyroid hormone level 0.2650366534861 0.540098068338575 0.898812469074715 0.5 18.2 18 2 abnormal PNS synaptic transmission 0.2650366534861 0.540098068338575 0.898812469074715 0.5 18.2 18 2 absent CD4-positive, alpha beta T cells 0.2650366534861 0.540098068338575 0.898812469074715 0.5 18.2 18 2 increased left ventricle diastolic pressure 0.2650366534861 0.540098068338575 0.898812469074715 0.5 18.2 18 2 abnormal embryonic erythrocyte morphology 0.2650366534861 0.540098068338575 0.898812469074715 0.5 18.2 18 2 abnormal utricular macula morphology 0.2650366534861 0.540098068338575 0.898812469074715 0.5 18.2 18 2 abnormal cochlear inner hair cell physiology 0.2650366534861 0.540098068338575 0.898812469074715 0.5 18.2 18 2 crystalluria 0.2650366534861 0.540098068338575 0.898812469074715 0.5 18.2 18 2 abnormal sperm principal piece morphology 0.2650366534861 0.540098068338575 0.898812469074715 0.5 18.2 18 2 abnormal cerebellar granule cell migration 0.2650366534861 0.540098068338575 0.898812469074715 0.5 18.2 18 2 increased serotonin level 0.2650366534861 0.540098068338575 0.898812469074715 0.5 18.2 18 2 increased T-helper 17 cell number 0.2650366534861 0.540098068338575 0.898812469074715 0.5 18.2 18 2 thick aortic valve cusps 0.2650366534861 0.540098068338575 0.898812469074715 0.5 18.2 18 2 decreased macrophage apoptosis 0.2650366534861 0.540098068338575 0.898812469074715 0.5 18.2 18 2 abnormal compact bone morphology 0.0500198388072954 0.181244499684118 0.898812469074715 0.5 18.2 18 2 increased metastatic potential 0.0770211440202919 0.242980463856026 0.898812469074715 0.5 18.2 18 2 abnormal synaptic transmission 0.0770211440202919 0.242980463856026 0.898812469074715 0.5 18.2 18 2 increased leukocyte cell number 0.000400484144294073 0.00402506791487477 0.892613762391442 0.496551724137931 18.2 18 2 abnormal eye electrophysiology 0.00121430412409561 0.0103444572215337 0.891384266850957 0.495867768595041 18.2 18 2 abnormal CNS synaptic transmission 0.00340279876834918 0.0243231664835305 0.889733555245678 0.494949494949495 18.2 18 2 increased double-negative T cell number 0.021298221061035 0.098657960687755 0.884077838434146 0.491803278688525 18.2 18 2 abnormal male meiosis 0.021298221061035 0.098657960687755 0.884077838434146 0.491803278688525 18.2 18 2 increased B cell proliferation 0.0235285827841417 0.107192948123722 0.883578359429381 0.491525423728814 18.2 18 2 increased fluid intake 0.0389968558136713 0.155705744520878 0.880469357460946 0.489795918367347 18.2 18 2 abnormal ovarian follicle morphology 0.0479287103670289 0.174969632604867 0.878838858650833 0.488888888888889 18.2 18 2 irregular heartbeat 0.0479287103670289 0.174969632604867 0.878838858650833 0.488888888888889 18.2 18 2 abnormal response/metabolism to endogenous compounds 0.0103330691508613 0.0557559859279123 0.87689021373143 0.48780487804878 18.2 18 2 abnormal social investigation 0.0113776985691835 0.0609957439457844 0.876342157347848 0.4875 18.2 18 2 decreased IgG level 0.00350083121324649 0.0247044472140444 0.874520240180804 0.486486486486487 18.2 18 2 abnormal long bone metaphysis morphology 0.0730881828081143 0.233085711198954 0.874520240180804 0.486486486486487 18.2 18 2 abnormal heart left ventricle morphology 0.0167683479531472 0.0797538537924544 0.873845456044862 0.486111111111111 18.2 18 2 increased circulating serum albumin level 0.0814178251809493 0.255232312712806 0.873132112815438 0.485714285714286 18.2 18 2 abnormal intestinal goblet cell morphology 0.0814178251809493 0.255232312712806 0.873132112815438 0.485714285714286 18.2 18 2 impaired swimming 0.0225002287727968 0.10355100660931 0.871575727587603 0.484848484848485 18.2 18 2 abnormal aorta morphology 0.0908044347236294 0.280591343323016 0.871575727587603 0.484848484848485 18.2 18 2 abnormal epidermis stratum basale morphology 0.0908044347236294 0.280591343323016 0.871575727587603 0.484848484848485 18.2 18 2 cardiovascular system phenotype 0.0908044347236294 0.280591343323016 0.871575727587603 0.484848484848485 18.2 18 2 decreased sensitivity to xenobiotic induced morbidity/mortality 0.0908044347236294 0.280591343323016 0.871575727587603 0.484848484848485 18.2 18 2 autoimmune response 0.101407364022884 0.306315504562142 0.869818518459402 0.483870967741935 18.2 18 2 decreased susceptibility to bacterial infection induced morbidity/mortality 0.101407364022884 0.306315504562142 0.869818518459402 0.483870967741935 18.2 18 2 abnormal intestine physiology 0.101407364022884 0.306315504562142 0.869818518459402 0.483870967741935 18.2 18 2 aphagia 0.113416852552563 0.316122954191448 0.867818935658346 0.482758620689655 18.2 18 2 abnormal embryonic erythropoiesis 0.113416852552563 0.316122954191448 0.867818935658346 0.482758620689655 18.2 18 2 abnormal CD8-positive, alpha-beta T cell physiology 0.113416852552563 0.316122954191448 0.867818935658346 0.482758620689655 18.2 18 2 enlarged epididymis 0.113416852552563 0.316122954191448 0.867818935658346 0.482758620689655 18.2 18 2 increased retinal apoptosis 0.113416852552563 0.316122954191448 0.867818935658346 0.482758620689655 18.2 18 2 decreased susceptibility to pharmacologically induced seizures 0.127062174990501 0.316122954191448 0.865523118368245 0.481481481481481 18.2 18 2 abnormal female meiosis 0.0453030889492081 0.168539609394208 0.864242758725688 0.480769230769231 18.2 18 2 obese 0.0175761003649035 0.0831189156990444 0.863793801448428 0.480519480519481 18.2 18 2 abnormal circulating protein level 0.0501658501307856 0.181641269578354 0.862859970311727 0.48 18.2 18 2 abnormal inner ear vestibule morphology 0.142622730097373 0.333121165368277 0.862859970311727 0.48 18.2 18 2 increased pre-B cell number 0.142622730097373 0.333121165368277 0.862859970311727 0.48 18.2 18 2 abnormal lymphocyte physiology 0.0616280815456286 0.199999808016635 0.859733666071467 0.478260869565217 18.2 18 2 abnormal blood vessel physiology 0.160443478868403 0.369142954736292 0.859733666071467 0.478260869565217 18.2 18 2 pancreas inflammation 0.160443478868403 0.369142954736292 0.859733666071467 0.478260869565217 18.2 18 2 abnormal cochlear ganglion morphology 0.160443478868403 0.369142954736292 0.859733666071467 0.478260869565217 18.2 18 2 abnormal cardiovascular development 0.160443478868403 0.369142954736292 0.859733666071467 0.478260869565217 18.2 18 2 abnormal lens development 0.160443478868403 0.369142954736292 0.859733666071467 0.478260869565217 18.2 18 2 decreased effector memory CD8-positive, alpha-beta T cell number 0.160443478868403 0.369142954736292 0.859733666071467 0.478260869565217 18.2 18 2 increased body weight 0.000139394262093997 0.00164810185816049 0.858686912419594 0.477678571428571 18.2 18 2 decreased compact bone thickness 0.0285938441393423 0.119632672080247 0.858567134638534 0.477611940298507 18.2 18 2 lethality, incomplete penetrance 0.0683773842994436 0.218623063553812 0.857957356844047 0.477272727272727 18.2 18 2 abnormal scapula morphology 0.180957008562287 0.408837928064204 0.856011875309253 0.476190476190476 18.2 18 2 dry skin 0.180957008562287 0.408837928064204 0.856011875309253 0.476190476190476 18.2 18 2 increased keratinocyte proliferation 0.180957008562287 0.408837928064204 0.856011875309253 0.476190476190476 18.2 18 2 increased bone ossification 0.180957008562287 0.408837928064204 0.856011875309253 0.476190476190476 18.2 18 2 abnormal excitatory postsynaptic potential 0.0182689812770247 0.0860683540276495 0.854967958388144 0.475609756097561 18.2 18 2 abnormal maternal nurturing 0.0384381191355813 0.153598106585957 0.854608577153008 0.475409836065574 18.2 18 2 abnormal skin pigmentation 0.0843738880609185 0.262514129520369 0.85387184562098 0.475 18.2 18 2 syndactyly 0.0424542981313349 0.167627089843961 0.853110140138713 0.474576271186441 18.2 18 2 abnormal reproductive system physiology 0.0938496924088512 0.286267455385674 0.85150654964973 0.473684210526316 18.2 18 2 abnormal retinal outer nuclear layer morphology 0.0938496924088512 0.286267455385674 0.85150654964973 0.473684210526316 18.2 18 2 enlarged adrenal glands 0.20471604080809 0.448963795538108 0.85150654964973 0.473684210526316 18.2 18 2 short vibrissae 0.20471604080809 0.448963795538108 0.85150654964973 0.473684210526316 18.2 18 2 stereotypic behavior 0.20471604080809 0.448963795538108 0.85150654964973 0.473684210526316 18.2 18 2 decreased grooming behavior 0.20471604080809 0.448963795538108 0.85150654964973 0.473684210526316 18.2 18 2 abnormal long term depression 0.20471604080809 0.448963795538108 0.85150654964973 0.473684210526316 18.2 18 2 abnormal response to novelty 0.20471604080809 0.448963795538108 0.85150654964973 0.473684210526316 18.2 18 2 abnormal optic vesicle formation 0.20471604080809 0.448963795538108 0.85150654964973 0.473684210526316 18.2 18 2 absent amnion 0.20471604080809 0.448963795538108 0.85150654964973 0.473684210526316 18.2 18 2 decreased eye pigmentation 0.20471604080809 0.448963795538108 0.85150654964973 0.473684210526316 18.2 18 2 decreased T cell proliferation 0.00248737735698327 0.0183639013338246 0.850228011286893 0.472972972972973 18.2 18 2 small ovary 0.0156127305334421 0.0765254526146547 0.849427168576105 0.472527472527473 18.2 18 2 abnormal vision 0.116474170241195 0.316122954191448 0.845941147364438 0.470588235294118 18.2 18 2 decreased regulatory T cell number 0.116474170241195 0.316122954191448 0.845941147364438 0.470588235294118 18.2 18 2 abnormal glutamate-mediated receptor currents 0.232443069424188 0.494612604955233 0.845941147364438 0.470588235294118 18.2 18 2 decreased vasoconstriction 0.232443069424188 0.494612604955233 0.845941147364438 0.470588235294118 18.2 18 2 abnormal duodenum morphology 0.232443069424188 0.494612604955233 0.845941147364438 0.470588235294118 18.2 18 2 increased regulatory T cell number 0.232443069424188 0.494612604955233 0.845941147364438 0.470588235294118 18.2 18 2 abnormal melanosome morphology 0.232443069424188 0.494612604955233 0.845941147364438 0.470588235294118 18.2 18 2 abnormal survival 0.232443069424188 0.494612604955233 0.845941147364438 0.470588235294118 18.2 18 2 abnormal cued conditioning behavior 0.0634597423256191 0.204742035064822 0.845941147364438 0.470588235294118 18.2 18 2 abnormal crypts of Lieberkuhn morphology 0.129986230675882 0.316122954191448 0.842636689757546 0.46875 18.2 18 2 abnormal lymphatic vessel morphology 0.129986230675882 0.316122954191448 0.842636689757546 0.46875 18.2 18 2 abnormal T-helper 1 physiology 0.0778289729441409 0.245373346259253 0.841441460410372 0.468085106382979 18.2 18 2 abnormal cytokine secretion 0.00315214325499968 0.0227603957817466 0.840448023030903 0.467532467532468 18.2 18 2 decreased osteoclast cell number 0.0862699739903064 0.268078151531402 0.838891637803068 0.466666666666667 18.2 18 2 abnormal hair cycle 0.1452630975183 0.33865225405508 0.838891637803068 0.466666666666667 18.2 18 2 gastrointestinal hemorrhage 0.1452630975183 0.33865225405508 0.838891637803068 0.466666666666667 18.2 18 2 emphysema 0.1452630975183 0.33865225405508 0.838891637803068 0.466666666666667 18.2 18 2 interdigital webbing 0.265109443795538 0.540098068338575 0.838891637803068 0.466666666666667 18.2 18 2 altered righting response 0.265109443795538 0.540098068338575 0.838891637803068 0.466666666666667 18.2 18 2 abnormal rostral migratory stream morphology 0.265109443795538 0.540098068338575 0.838891637803068 0.466666666666667 18.2 18 2 abnormal zygomatic bone morphology 0.265109443795538 0.540098068338575 0.838891637803068 0.466666666666667 18.2 18 2 abnormal neurotransmitter secretion 0.265109443795538 0.540098068338575 0.838891637803068 0.466666666666667 18.2 18 2 increased food intake 0.0281521266130713 0.118377301615527 0.834611578426522 0.464285714285714 18.2 18 2 abnormal circulating cholesterol level 0.162582768823251 0.370816999693502 0.834611578426522 0.464285714285714 18.2 18 2 abnormal spleen germinal center morphology 0.162582768823251 0.370816999693502 0.834611578426522 0.464285714285714 18.2 18 2 enhanced coordination 0.162582768823251 0.370816999693502 0.834611578426522 0.464285714285714 18.2 18 2 increased tumor growth/size 0.106217207157254 0.314542027147226 0.833045703044858 0.463414634146341 18.2 18 2 polyphagia 0.0715022077032684 0.228320592633993 0.832233767661774 0.462962962962963 18.2 18 2 abnormal hair growth 0.0790225880768284 0.248349574025408 0.829673048376661 0.461538461538462 18.2 18 2 no spontaneous movement 0.182280268342028 0.410322318098168 0.829673048376661 0.461538461538462 18.2 18 2 abnormal tectorial membrane morphology 0.182280268342028 0.410322318098168 0.829673048376661 0.461538461538462 18.2 18 2 abnormal renal/urinary system morphology 0.304068006178761 0.559740046600862 0.829673048376661 0.461538461538462 18.2 18 2 abnormal sympathetic ganglion morphology 0.304068006178761 0.559740046600862 0.829673048376661 0.461538461538462 18.2 18 2 excessive scratching 0.304068006178761 0.559740046600862 0.829673048376661 0.461538461538462 18.2 18 2 lymphoid hypoplasia 0.304068006178761 0.559740046600862 0.829673048376661 0.461538461538462 18.2 18 2 abnormal otolith morphology 0.304068006178761 0.559740046600862 0.829673048376661 0.461538461538462 18.2 18 2 vestibular hair cell degeneration 0.304068006178761 0.559740046600862 0.829673048376661 0.461538461538462 18.2 18 2 small pituitary gland 0.304068006178761 0.559740046600862 0.829673048376661 0.461538461538462 18.2 18 2 impaired macrophage chemotaxis 0.117994342582155 0.316122954191448 0.82967304837666 0.461538461538462 18.2 18 2 decreased trabecular bone volume 0.117994342582155 0.316122954191448 0.82967304837666 0.461538461538462 18.2 18 2 increased insulin secretion 0.13118920484463 0.316122954191448 0.825935782392982 0.459459459459459 18.2 18 2 decreased body height 0.204763588356978 0.448963795538108 0.823911429985156 0.458333333333333 18.2 18 2 abnormal sensory capabilities/reflexes/nociception 0.204763588356978 0.448963795538108 0.823911429985156 0.458333333333333 18.2 18 2 prolonged QT interval 0.204763588356978 0.448963795538108 0.823911429985156 0.458333333333333 18.2 18 2 abnormal retinal ganglion layer morphology 0.204763588356978 0.448963795538108 0.823911429985156 0.458333333333333 18.2 18 2 absent vitelline blood vessels 0.0796664106701752 0.250057030336985 0.819969270033074 0.456140350877193 18.2 18 2 decreased susceptibility to injury 0.0599892671022696 0.197634890938907 0.819505486509299 0.455882352941176 18.2 18 2 abnormal T cell differentiation 0.026678751854445 0.115615671146223 0.818720268860137 0.455445544554455 18.2 18 2 decreased anxiety-related response 0.0158770840188618 0.0775156947927749 0.818430866149334 0.455284552845528 18.2 18 2 decreased systemic arterial blood pressure 0.162637727302758 0.370816999693502 0.817102244613378 0.454545454545455 18.2 18 2 head tossing 0.162637727302758 0.370816999693502 0.817102244613378 0.454545454545455 18.2 18 2 short femur 0.0381056130747663 0.152391820777301 0.817102244613378 0.454545454545455 18.2 18 2 hypertension 0.118451805142532 0.316122954191448 0.817102244613378 0.454545454545455 18.2 18 2 abnormal tracheal cartilage morphology 0.230535661727714 0.491816002184982 0.817102244613378 0.454545454545455 18.2 18 2 abnormal limb posture 0.230535661727714 0.491816002184982 0.817102244613378 0.454545454545455 18.2 18 2 abnormal temporal bone morphology 0.230535661727714 0.491816002184982 0.817102244613378 0.454545454545455 18.2 18 2 abnormal ear position 0.351290110543459 0.559740046600862 0.817102244613378 0.454545454545455 18.2 18 2 enlarged cranium 0.351290110543459 0.559740046600862 0.817102244613378 0.454545454545455 18.2 18 2 decreased post-tetanic potentiation 0.351290110543459 0.559740046600862 0.817102244613378 0.454545454545455 18.2 18 2 variable body spotting 0.351290110543459 0.559740046600862 0.817102244613378 0.454545454545455 18.2 18 2 allodynia 0.351290110543459 0.559740046600862 0.817102244613378 0.454545454545455 18.2 18 2 abnormal nerve fiber response 0.351290110543459 0.559740046600862 0.817102244613378 0.454545454545455 18.2 18 2 dilated renal glomerular capsule 0.351290110543459 0.559740046600862 0.817102244613378 0.454545454545455 18.2 18 2 increased motor neuron number 0.351290110543459 0.559740046600862 0.817102244613378 0.454545454545455 18.2 18 2 abnormal dorsal-ventral polarity of the somites 0.351290110543459 0.559740046600862 0.817102244613378 0.454545454545455 18.2 18 2 abnormal superovulation 0.351290110543459 0.559740046600862 0.817102244613378 0.454545454545455 18.2 18 2 abnormal palatal shelf elevation 0.351290110543459 0.559740046600862 0.817102244613378 0.454545454545455 18.2 18 2 decreased palatine bone horizontal plate size 0.351290110543459 0.559740046600862 0.817102244613378 0.454545454545455 18.2 18 2 abnormal phrenic nerve innervation pattern to diaphragm 0.351290110543459 0.559740046600862 0.817102244613378 0.454545454545455 18.2 18 2 decreased eosinophil cell number 0.0725958103633152 0.23166398752886 0.814548800098961 0.453125 18.2 18 2 decreased inflammatory response 0.0457702450446544 0.168539609394208 0.81321128154379 0.452380952380952 18.2 18 2 abnormal nervous system electrophysiology 0.0457702450446544 0.168539609394208 0.81321128154379 0.452380952380952 18.2 18 2 abnormal cytotoxic T cell physiology 0.131242023734907 0.316122954191448 0.81321128154379 0.452380952380952 18.2 18 2 abnormal cranial ganglia morphology 0.181379583926289 0.409420794025992 0.811830617228775 0.451612903225806 18.2 18 2 impaired ovarian folliculogenesis 0.14550198719044 0.339050298019878 0.808931222167244 0.45 18.2 18 2 waved hair 0.26022533656745 0.536074968705202 0.808931222167244 0.45 18.2 18 2 abnormal circulating enzyme level 0.26022533656745 0.536074968705202 0.808931222167244 0.45 18.2 18 2 abnormal hearing physiology 0.26022533656745 0.536074968705202 0.808931222167244 0.45 18.2 18 2 abnormal trachea morphology 0.26022533656745 0.536074968705202 0.808931222167244 0.45 18.2 18 2 abnormal Peyer's patch T cell area morphology 0.26022533656745 0.536074968705202 0.808931222167244 0.45 18.2 18 2 abnormal heart electrocardiography waveform feature 0.26022533656745 0.536074968705202 0.808931222167244 0.45 18.2 18 2 abnormal circulating glucose level 0.202530075793185 0.446625499588251 0.805831868825607 0.448275862068966 18.2 18 2 decreased retinal photoreceptor cell number 0.202530075793185 0.446625499588251 0.805831868825607 0.448275862068966 18.2 18 2 stomach inflammation 0.202530075793185 0.446625499588251 0.805831868825607 0.448275862068966 18.2 18 2 increased grooming behavior 0.161416429197404 0.369142954736292 0.804200630224745 0.447368421052632 18.2 18 2 decreased threshold for auditory brainstem response 0.161416429197404 0.369142954736292 0.804200630224745 0.447368421052632 18.2 18 2 decreased monocyte cell number 0.0875969775023884 0.272031812156293 0.802017280097439 0.446153846153846 18.2 18 2 skin lesions 0.0962126048436067 0.293295164887833 0.798944416955303 0.444444444444444 18.2 18 2 abnormal inflammatory response 0.0793710787140578 0.249287321087397 0.798944416955303 0.444444444444444 18.2 18 2 altered response to myocardial infarction 0.144197270064313 0.336640740764878 0.798944416955303 0.444444444444444 18.2 18 2 head tilt 0.179196232729762 0.405596568621732 0.798944416955303 0.444444444444444 18.2 18 2 abnormal iron level 0.294632169924116 0.559740046600862 0.798944416955303 0.444444444444444 18.2 18 2 eye inflammation 0.294632169924116 0.559740046600862 0.798944416955303 0.444444444444444 18.2 18 2 abnormal Peyer's patch follicle morphology 0.294632169924116 0.559740046600862 0.798944416955303 0.444444444444444 18.2 18 2 abnormal eye anterior chamber morphology 0.294632169924116 0.559740046600862 0.798944416955303 0.444444444444444 18.2 18 2 abnormal sperm axoneme morphology 0.294632169924116 0.559740046600862 0.798944416955303 0.444444444444444 18.2 18 2 impaired macrophage phagocytosis 0.159386817923921 0.368813683335586 0.79429939127533 0.441860465116279 18.2 18 2 thin skin 0.199082640772413 0.441734019367859 0.793069825654161 0.441176470588235 18.2 18 2 decreased pancreatic beta cell number 0.199082640772413 0.441734019367859 0.793069825654161 0.441176470588235 18.2 18 2 increased susceptibility to viral infection induced morbidity/mortality 0.199082640772413 0.441734019367859 0.793069825654161 0.441176470588235 18.2 18 2 abnormal primitive streak morphology 0.253588548418097 0.523704038347875 0.79095497278575 0.44 18.2 18 2 decreased placenta weight 0.253588548418097 0.523704038347875 0.79095497278575 0.44 18.2 18 2 abnormal hair shaft morphology 0.156836378059116 0.363080958978178 0.786460910440376 0.4375 18.2 18 2 abnormal long term potentiation 0.221352192009939 0.475076425905714 0.786460910440376 0.4375 18.2 18 2 abnormal serotonin level 0.221352192009939 0.475076425905714 0.786460910440376 0.4375 18.2 18 2 abnormal bone marrow cell number 0.334793090084553 0.559740046600862 0.786460910440376 0.4375 18.2 18 2 delayed hair appearance 0.334793090084553 0.559740046600862 0.786460910440376 0.4375 18.2 18 2 abnormal mouth morphology 0.334793090084553 0.559740046600862 0.786460910440376 0.4375 18.2 18 2 disorganized retinal layers 0.334793090084553 0.559740046600862 0.786460910440376 0.4375 18.2 18 2 abnormal intestinal lipid absorption 0.334793090084553 0.559740046600862 0.786460910440376 0.4375 18.2 18 2 abnormal Langerhans cell physiology 0.334793090084553 0.559740046600862 0.786460910440376 0.4375 18.2 18 2 impaired behavioral response to addictive substance 0.334793090084553 0.559740046600862 0.786460910440376 0.4375 18.2 18 2 decreased skeletal muscle weight 0.334793090084553 0.559740046600862 0.786460910440376 0.4375 18.2 18 2 dilated respiratory conducting tubes 0.334793090084553 0.559740046600862 0.786460910440376 0.4375 18.2 18 2 abnormal learning/memory/conditioning 0.140121500481274 0.330381262983098 0.784418154828843 0.436363636363636 18.2 18 2 increased eosinophil cell number 0.125588339400077 0.316122954191448 0.782836666613462 0.435483870967742 18.2 18 2 abnormal sleep pattern 0.172834275003141 0.39370444969809 0.78157606006497 0.434782608695652 18.2 18 2 fragile skeleton 0.284452725465646 0.55800492312737 0.78157606006497 0.434782608695652 18.2 18 2 abnormal innervation pattern to muscle 0.284452725465646 0.55800492312737 0.78157606006497 0.434782608695652 18.2 18 2 blistering 0.284452725465646 0.55800492312737 0.78157606006497 0.434782608695652 18.2 18 2 increased susceptibility to age related obesity 0.284452725465646 0.55800492312737 0.78157606006497 0.434782608695652 18.2 18 2 abnormal crista ampullaris morphology 0.284452725465646 0.55800492312737 0.78157606006497 0.434782608695652 18.2 18 2 abnormal B cell morphology 0.284452725465646 0.55800492312737 0.78157606006497 0.434782608695652 18.2 18 2 abnormal ulna morphology 0.284452725465646 0.55800492312737 0.78157606006497 0.434782608695652 18.2 18 2 abnormal eye physiology 0.137645609073685 0.324697441982734 0.77897080653142 0.433333333333333 18.2 18 2 salivary gland inflammation 0.246322470944567 0.510168932885088 0.77897080653142 0.433333333333333 18.2 18 2 abnormal estrous cycle 0.246322470944567 0.510168932885088 0.77897080653142 0.433333333333333 18.2 18 2 increased white adipose tissue amount 0.215773015880339 0.463502052679053 0.777351324605159 0.432432432432432 18.2 18 2 abnormal gametogenesis 0.190497427637777 0.42346948279622 0.776247132382709 0.431818181818182 18.2 18 2 abnormal thrombosis 0.169147001122081 0.385481598984129 0.775446051750735 0.431372549019608 18.2 18 2 impaired fertilization 0.132249959739702 0.316122954191448 0.770410687778328 0.428571428571429 18.2 18 2 abnormal action potential 0.132249959739702 0.316122954191448 0.770410687778328 0.428571428571429 18.2 18 2 shortened head 0.27435872367325 0.55800492312737 0.770410687778328 0.428571428571429 18.2 18 2 abnormal adrenal gland secretion 0.382084828053668 0.583805902815417 0.770410687778328 0.428571428571429 18.2 18 2 abnormal olfactory system physiology 0.382084828053668 0.583805902815417 0.770410687778328 0.428571428571429 18.2 18 2 abnormal kidney medulla morphology 0.382084828053668 0.583805902815417 0.770410687778328 0.428571428571429 18.2 18 2 intestinal obstruction 0.382084828053668 0.583805902815417 0.770410687778328 0.428571428571429 18.2 18 2 abnormal uterus development 0.382084828053668 0.583805902815417 0.770410687778328 0.428571428571429 18.2 18 2 skeletal muscle necrosis 0.382084828053668 0.583805902815417 0.770410687778328 0.428571428571429 18.2 18 2 decreased compact bone area 0.382084828053668 0.583805902815417 0.770410687778328 0.428571428571429 18.2 18 2 decreased response to antigen 0.382084828053668 0.583805902815417 0.770410687778328 0.428571428571429 18.2 18 2 increased incidence of induced tumors 0.319676582571321 0.559740046600862 0.770410687778328 0.428571428571429 18.2 18 2 abnormal associative learning 0.319676582571321 0.559740046600862 0.770410687778328 0.428571428571429 18.2 18 2 abnormal NK cell physiology 0.16138875307094 0.369142954736292 0.766200793309594 0.426229508196721 18.2 18 2 decreased tumor growth/size 0.181124720597511 0.409031087141452 0.765655066248832 0.425925925925926 18.2 18 2 abnormal ovarian folliculogenesis 0.264615481794177 0.540098068338575 0.762628761639152 0.424242424242424 18.2 18 2 increased percent body fat/body weight 0.198428630361999 0.440903276485459 0.760533627678605 0.423076923076923 18.2 18 2 abnormal leukocyte cell number 0.305881287140547 0.559740046600862 0.760533627678605 0.423076923076923 18.2 18 2 small seminal vesicle 0.305881287140547 0.559740046600862 0.760533627678605 0.423076923076923 18.2 18 2 increased circulating corticosterone level 0.224332158172232 0.481264548040902 0.758997196107538 0.422222222222222 18.2 18 2 flaky skin 0.360025718372134 0.563070716410363 0.75689471079976 0.421052631578947 18.2 18 2 oliguria 0.360025718372134 0.563070716410363 0.75689471079976 0.421052631578947 18.2 18 2 decreased fertilization frequency 0.360025718372134 0.563070716410363 0.75689471079976 0.421052631578947 18.2 18 2 right-sided stomach 0.360025718372134 0.563070716410363 0.75689471079976 0.421052631578947 18.2 18 2 absent mature ovarian follicles 0.293225667124435 0.559740046600862 0.753842715998148 0.419354838709677 18.2 18 2 abnormal CD8-positive, alpha beta T cell morphology 0.293225667124435 0.559740046600862 0.753842715998148 0.419354838709677 18.2 18 2 abnormal T cell proliferation 0.293225667124435 0.559740046600862 0.753842715998148 0.419354838709677 18.2 18 2 increased susceptibility to pharmacologically induced seizures 0.134796810104591 0.318581534570234 0.749010390895596 0.416666666666667 18.2 18 2 increased stereotypic behavior 0.341373537686123 0.559740046600862 0.749010390895596 0.416666666666667 18.2 18 2 abnormal vasodilation 0.341373537686123 0.559740046600862 0.749010390895596 0.416666666666667 18.2 18 2 abnormal impulse conducting system conduction 0.341373537686123 0.559740046600862 0.749010390895596 0.416666666666667 18.2 18 2 decreased ovulation rate 0.341373537686123 0.559740046600862 0.749010390895596 0.416666666666667 18.2 18 2 abnormal osteoblast morphology 0.341373537686123 0.559740046600862 0.749010390895596 0.416666666666667 18.2 18 2 abnormal rectum morphology 0.438386877894091 0.653208204777568 0.749010390895596 0.416666666666667 18.2 18 2 decreased digestive secretion 0.438386877894091 0.653208204777568 0.749010390895596 0.416666666666667 18.2 18 2 amyloidosis 0.438386877894091 0.653208204777568 0.749010390895596 0.416666666666667 18.2 18 2 abnormal pilomotor reflex 0.438386877894091 0.653208204777568 0.749010390895596 0.416666666666667 18.2 18 2 abnormal tracheal ciliated epithelium morphology 0.438386877894091 0.653208204777568 0.749010390895596 0.416666666666667 18.2 18 2 increased growth rate 0.438386877894091 0.653208204777568 0.749010390895596 0.416666666666667 18.2 18 2 abnormal AMPA-mediated synaptic currents 0.438386877894091 0.653208204777568 0.749010390895596 0.416666666666667 18.2 18 2 increased urine phosphate level 0.438386877894091 0.653208204777568 0.749010390895596 0.416666666666667 18.2 18 2 increased circulating parathyroid hormone level 0.438386877894091 0.653208204777568 0.749010390895596 0.416666666666667 18.2 18 2 absent tail 0.438386877894091 0.653208204777568 0.749010390895596 0.416666666666667 18.2 18 2 impaired sperm capacitation 0.438386877894091 0.653208204777568 0.749010390895596 0.416666666666667 18.2 18 2 stria vascularis degeneration 0.438386877894091 0.653208204777568 0.749010390895596 0.416666666666667 18.2 18 2 increased placenta weight 0.438386877894091 0.653208204777568 0.749010390895596 0.416666666666667 18.2 18 2 abnormal B cell proliferation 0.438386877894091 0.653208204777568 0.749010390895596 0.416666666666667 18.2 18 2 abnormal amacrine cell morphology 0.438386877894091 0.653208204777568 0.749010390895596 0.416666666666667 18.2 18 2 abnormal palatine bone morphology 0.438386877894091 0.653208204777568 0.749010390895596 0.416666666666667 18.2 18 2 abnormal patella morphology 0.438386877894091 0.653208204777568 0.749010390895596 0.416666666666667 18.2 18 2 hemoperitoneum 0.438386877894091 0.653208204777568 0.749010390895596 0.416666666666667 18.2 18 2 impaired behavioral response to cocaine 0.438386877894091 0.653208204777568 0.749010390895596 0.416666666666667 18.2 18 2 arrested B cell differentiation 0.270694321121681 0.551250203675956 0.745356681671715 0.414634146341463 18.2 18 2 lung hemorrhage 0.310488470509412 0.559740046600862 0.740198503943883 0.411764705882353 18.2 18 2 abnormal bone remodeling 0.310488470509412 0.559740046600862 0.740198503943883 0.411764705882353 18.2 18 2 abnormal urinary bladder morphology 0.40643810454681 0.619494353590802 0.740198503943883 0.411764705882353 18.2 18 2 abnormal heart rate 0.40643810454681 0.619494353590802 0.740198503943883 0.411764705882353 18.2 18 2 abnormal touch/ nociception 0.40643810454681 0.619494353590802 0.740198503943883 0.411764705882353 18.2 18 2 abnormal tendon morphology 0.40643810454681 0.619494353590802 0.740198503943883 0.411764705882353 18.2 18 2 abnormal circulating chemokine level 0.40643810454681 0.619494353590802 0.740198503943883 0.411764705882353 18.2 18 2 abnormal humoral immune response 0.155491848314791 0.360135914974899 0.736170212765958 0.40952380952381 18.2 18 2 increased activated T cell number 0.381389527770742 0.583805902815417 0.73539202015204 0.409090909090909 18.2 18 2 abnormal oogenesis 0.381389527770742 0.583805902815417 0.73539202015204 0.409090909090909 18.2 18 2 decreased susceptibility to viral infection induced morbidity/mortality 0.381389527770742 0.583805902815417 0.73539202015204 0.409090909090909 18.2 18 2 rough coat 0.381389527770742 0.583805902815417 0.73539202015204 0.409090909090909 18.2 18 2 increased bone volume 0.381389527770742 0.583805902815417 0.73539202015204 0.409090909090909 18.2 18 2 wrinkled skin 0.360487036221189 0.563615023633066 0.732365715542361 0.407407407407407 18.2 18 2 abnormal diaphragm morphology 0.34240225536067 0.559740046600862 0.730285131123206 0.40625 18.2 18 2 hyperkeratosis 0.236165706245002 0.502319105843902 0.729470989393972 0.405797101449275 18.2 18 2 decreased bone trabecula number 0.298830939139005 0.559740046600862 0.726699443081685 0.404255319148936 18.2 18 2 abnormal leukocyte migration 0.28675504913141 0.55800492312737 0.725963917329578 0.403846153846154 18.2 18 2 impaired natural killer cell mediated cytotoxicity 0.275573614314523 0.55800492312737 0.725357431183104 0.403508771929825 18.2 18 2 abnormal energy expenditure 0.399896863864807 0.610459311975273 0.719049975259772 0.4 18.2 18 2 head bobbing 0.341106962205221 0.559740046600862 0.719049975259772 0.4 18.2 18 2 arrested T cell differentiation 0.377553850449309 0.579195314827417 0.719049975259772 0.4 18.2 18 2 abnormal pain threshold 0.377553850449309 0.579195314827417 0.719049975259772 0.4 18.2 18 2 enhanced paired-pulse facilitation 0.377553850449309 0.579195314827417 0.719049975259772 0.4 18.2 18 2 nuclear cataracts 0.426559306241924 0.644437457805518 0.719049975259772 0.4 18.2 18 2 decreased salivation 0.460068417559088 0.666329076377427 0.719049975259772 0.4 18.2 18 2 hyperpigmentation 0.460068417559088 0.666329076377427 0.719049975259772 0.4 18.2 18 2 arthritis 0.460068417559088 0.666329076377427 0.719049975259772 0.4 18.2 18 2 increased alcohol consumption 0.460068417559088 0.666329076377427 0.719049975259772 0.4 18.2 18 2 decreased aggression towards males 0.460068417559088 0.666329076377427 0.719049975259772 0.4 18.2 18 2 abnormal lymph node morphology 0.338677695452111 0.559740046600862 0.711559871350816 0.395833333333333 18.2 18 2 abnormal intestinal mucosa morphology 0.354809644869575 0.559740046600862 0.710688929035822 0.395348837209302 18.2 18 2 abnormal immune system physiology 0.215541605175787 0.463204961446886 0.710351790075178 0.395161290322581 18.2 18 2 abnormal T cell activation 0.306492222499297 0.559740046600862 0.704474637923426 0.391891891891892 18.2 18 2 abnormal immune system morphology 0.367620992391916 0.565231093778939 0.703418454058473 0.391304347826087 18.2 18 2 failure of embryo implantation 0.443706043538304 0.653208204777568 0.703418454058473 0.391304347826087 18.2 18 2 decreased epididymis weight 0.443706043538304 0.653208204777568 0.703418454058473 0.391304347826087 18.2 18 2 increased susceptibility to fungal infection 0.443706043538304 0.653208204777568 0.703418454058473 0.391304347826087 18.2 18 2 scaly skin 0.386171052498687 0.589868279453783 0.701512170985144 0.390243902439024 18.2 18 2 abnormal reflex 0.407007256282999 0.619719614560574 0.69907636483589 0.388888888888889 18.2 18 2 abnormal macrophage chemotaxis 0.477587335670342 0.69089764319859 0.69907636483589 0.388888888888889 18.2 18 2 decreased susceptibility to induced arthritis 0.37341343917289 0.573374030828744 0.693820151566447 0.385964912280702 18.2 18 2 decreased IgA level 0.390976675557431 0.597025463750221 0.69139420698055 0.384615384615385 18.2 18 2 decreased Peyer's patch number 0.458656599317471 0.665252647698081 0.69139420698055 0.384615384615385 18.2 18 2 short hair 0.522336172716173 0.742039537196733 0.69139420698055 0.384615384615385 18.2 18 2 abnormal intercostal muscle morphology 0.522336172716173 0.742039537196733 0.69139420698055 0.384615384615385 18.2 18 2 abnormal retinal inner plexiform layer morphology 0.522336172716173 0.742039537196733 0.69139420698055 0.384615384615385 18.2 18 2 increased circulating thyroid-stimulating hormone level 0.522336172716173 0.742039537196733 0.69139420698055 0.384615384615385 18.2 18 2 abnormal hair follicle inner root sheath morphology 0.522336172716173 0.742039537196733 0.69139420698055 0.384615384615385 18.2 18 2 abnormal lens fiber morphology 0.419906794769822 0.634772501968965 0.69139420698055 0.384615384615385 18.2 18 2 decreased vocalization 0.492333290039217 0.704648480421492 0.684809500247402 0.380952380952381 18.2 18 2 increased neutrophil cell number 0.319199145518374 0.559740046600862 0.681857735160129 0.379310344827586 18.2 18 2 absent long term depression 0.47192345657769 0.683101308255457 0.681857735160129 0.379310344827586 18.2 18 2 decreased bone strength 0.47192345657769 0.683101308255457 0.681857735160129 0.379310344827586 18.2 18 2 enhanced long term potentiation 0.441305260567035 0.653208204777568 0.674109351806037 0.375 18.2 18 2 increased susceptibility to bacterial infection induced morbidity/mortality 0.421083137245214 0.636357414275498 0.674109351806037 0.375 18.2 18 2 increased circulating total protein level 0.505105547049612 0.720357731134759 0.674109351806037 0.375 18.2 18 2 abnormal pituitary gland morphology 0.535233614043808 0.759061354010247 0.674109351806037 0.375 18.2 18 2 mixed cellular infiltration to dermis 0.535233614043808 0.759061354010247 0.674109351806037 0.375 18.2 18 2 paternal imprinting 0.535233614043808 0.759061354010247 0.674109351806037 0.375 18.2 18 2 large intestinal inflammation 0.535233614043808 0.759061354010247 0.674109351806037 0.375 18.2 18 2 abnormal urinary bladder physiology 0.535233614043808 0.759061354010247 0.674109351806037 0.375 18.2 18 2 maternal imprinting 0.546164945760963 0.760824368291001 0.66228287194979 0.368421052631579 18.2 18 2 abnormal inhibitory postsynaptic currents 0.475667292854374 0.688320180904745 0.660891521378467 0.367647058823529 18.2 18 2 decreased macrophage cell number 0.522523091725837 0.742093171948627 0.653681795690702 0.363636363636364 18.2 18 2 abnormal T cell subpopulation ratio 0.535801797478488 0.75965059631105 0.653681795690702 0.363636363636364 18.2 18 2 abnormal female reproductive system physiology 0.555729725621203 0.760824368291001 0.653681795690702 0.363636363636364 18.2 18 2 abnormal digestive system physiology 0.538150913626044 0.760824368291001 0.647144977733795 0.36 18.2 18 2 abnormal feces composition 0.564285431341065 0.760824368291001 0.647144977733795 0.36 18.2 18 2 abnormal leukocyte adhesion 0.552178871707644 0.760824368291001 0.645301259848514 0.358974358974359 18.2 18 2 abnormal response to injury 0.552178871707644 0.760824368291001 0.645301259848514 0.358974358974359 18.2 18 2 decreased circulating progesterone level 0.572062445765356 0.760824368291001 0.64200890648194 0.357142857142857 18.2 18 2 abnormal zigzag hair morphology 0.600253586417565 0.770449327251647 0.64200890648194 0.357142857142857 18.2 18 2 abnormal antigen presentation 0.600253586417565 0.770449327251647 0.64200890648194 0.357142857142857 18.2 18 2 decreased coping response 0.600253586417565 0.770449327251647 0.64200890648194 0.357142857142857 18.2 18 2 abnormal imprinting 0.600253586417565 0.770449327251647 0.64200890648194 0.357142857142857 18.2 18 2 abnormal hair cuticle 0.600253586417565 0.770449327251647 0.64200890648194 0.357142857142857 18.2 18 2 abnormal squamosal bone morphology 0.600253586417565 0.770449327251647 0.64200890648194 0.357142857142857 18.2 18 2 abnormal positive T cell selection 0.600253586417565 0.770449327251647 0.64200890648194 0.357142857142857 18.2 18 2 increased B-1 B cell number 0.600253586417565 0.770449327251647 0.64200890648194 0.357142857142857 18.2 18 2 abnormal iris pigmentation 0.600253586417565 0.770449327251647 0.64200890648194 0.357142857142857 18.2 18 2 abnormal body temperature homeostasis 0.579218096503282 0.760824368291001 0.637866913536895 0.354838709677419 18.2 18 2 decreased growth hormone level 0.605485710133081 0.776764158822093 0.634455860523329 0.352941176470588 18.2 18 2 abnormal electroretinogram waveform feature 0.605485710133081 0.776764158822093 0.634455860523329 0.352941176470588 18.2 18 2 abnormal male reproductive system physiology 0.610567982425061 0.782678616996825 0.629168728352301 0.35 18.2 18 2 enhanced behavioral response to xenobiotic 0.610567982425061 0.782678616996825 0.629168728352301 0.35 18.2 18 2 abnormal circulating cytokine level 0.610567982425061 0.782678616996825 0.629168728352301 0.35 18.2 18 2 increased susceptibility to parasitic infection 0.639994213145887 0.819766017095981 0.61918192314036 0.344444444444444 18.2 18 2 decreased susceptibility to parasitic infection 0.629167232049525 0.806312977703861 0.617933572488867 0.34375 18.2 18 2 impaired behavioral response to xenobiotic 0.633417319922738 0.811550648111157 0.616328550222662 0.342857142857143 18.2 18 2 thick dermal layer 0.66943489736445 0.856400740208483 0.599208312716477 0.333333333333333 18.2 18 2 small lymph nodes 0.670660760573317 0.856400740208483 0.599208312716477 0.333333333333333 18.2 18 2 abnormal cardiac muscle contractility 0.670660760573317 0.856400740208483 0.599208312716477 0.333333333333333 18.2 18 2 increased acute inflammation 0.669685328617982 0.856400740208483 0.599208312716477 0.333333333333333 18.2 18 2 increased susceptibility to autoimmune disorder 0.66943489736445 0.856400740208483 0.599208312716477 0.333333333333333 18.2 18 2 abnormal cellular extravasation 0.670660760573317 0.856400740208483 0.599208312716477 0.333333333333333 18.2 18 2 impaired leukocyte tethering or rolling 0.66943489736445 0.856400740208483 0.599208312716477 0.333333333333333 18.2 18 2 abnormal food intake 0.703716605457756 0.882528387232754 0.599208312716477 0.333333333333333 18.2 18 2 decreased chondrocyte number 0.670346170846803 0.856400740208483 0.599208312716477 0.333333333333333 18.2 18 2 abnormal pup retrieval 0.670346170846803 0.856400740208483 0.599208312716477 0.333333333333333 18.2 18 2 abnormal seizure response to electrical stimulation 0.670346170846803 0.856400740208483 0.599208312716477 0.333333333333333 18.2 18 2 increased airway responsiveness 0.670346170846803 0.856400740208483 0.599208312716477 0.333333333333333 18.2 18 2 joint inflammation 0.670346170846803 0.856400740208483 0.599208312716477 0.333333333333333 18.2 18 2 decreased osteoblast cell number 0.718886351333666 0.886544547350915 0.581584538813051 0.323529411764706 18.2 18 2 reddish skin 0.719498243991649 0.886544547350915 0.577808015833746 0.321428571428571 18.2 18 2 abnormal stomach mucosa morphology 0.720719739035552 0.886544547350915 0.575239980207818 0.32 18.2 18 2 intestinal ulcer 0.722864610016479 0.886544547350915 0.571971571229364 0.318181818181818 18.2 18 2 altered susceptibility to infection 0.726328721181444 0.886544547350915 0.56767103309982 0.315789473684211 18.2 18 2 decreased mast cell number 0.731760969393618 0.886544547350915 0.561757793171697 0.3125 18.2 18 2 abnormal epididymis epithelium morphology 0.731760969393618 0.886544547350915 0.561757793171697 0.3125 18.2 18 2 abnormal wound healing 0.731760969393618 0.886544547350915 0.561757793171697 0.3125 18.2 18 2 increased circulating estradiol level 0.731760969393618 0.886544547350915 0.561757793171697 0.3125 18.2 18 2 abnormal pancreatic alpha cell morphology 0.731760969393618 0.886544547350915 0.561757793171697 0.3125 18.2 18 2 abnormal fertilization 0.731760969393618 0.886544547350915 0.561757793171697 0.3125 18.2 18 2 increased dopamine level 0.75975246267356 0.913649625767696 0.561757793171697 0.3125 18.2 18 2 increased susceptibility to induced arthritis 0.762127224175348 0.916283939166833 0.557883601494651 0.310344827586207 18.2 18 2 abnormal regulatory T cell physiology 0.769847262786737 0.925341901996621 0.547103242045479 0.304347826086957 18.2 18 2 decreased skin tensile strength 0.775940466362752 0.929471796430221 0.539287481444829 0.3 18.2 18 2 abnormal thymocyte activation 0.775940466362752 0.929471796430221 0.539287481444829 0.3 18.2 18 2 abnormal single cell response 0.804669766420308 0.959087706741982 0.532629611303535 0.296296296296296 18.2 18 2 distended urinary bladder 0.784375660752175 0.935795902216324 0.528713217102774 0.294117647058824 18.2 18 2 enlarged sebaceous gland 0.784375660752175 0.935795902216324 0.528713217102774 0.294117647058824 18.2 18 2 decreased cytotoxic T cell cytolysis 0.828459093367891 0.969465330884739 0.528713217102774 0.294117647058824 18.2 18 2 abnormal adrenal gland morphology 0.810688763698145 0.966030323209167 0.524307273626917 0.291666666666667 18.2 18 2 increased vasoconstriction 0.81844252146066 0.969465330884739 0.513607125185552 0.285714285714286 18.2 18 2 hypoalgesia 0.81844252146066 0.969465330884739 0.513607125185552 0.285714285714286 18.2 18 2 increased circulating luteinizing hormone level 0.838738375391771 0.979972620379066 0.513607125185552 0.285714285714286 18.2 18 2 impaired conditioned place preference behavior 0.845676717733598 0.985071803026141 0.503334982681841 0.28 18.2 18 2 decreased heart rate variability 0.828583646670531 0.969465330884739 0.499340260597064 0.277777777777778 18.2 18 2 abnormal systemic arterial blood pressure 0.880973601504109 1 0.499340260597064 0.277777777777778 18.2 18 2 increased systemic arterial blood pressure 0.907037659952967 1 0.497215408424311 0.276595744680851 18.2 18 2 increased double-positive T cell number 0.867923575855171 1 0.495896534661912 0.275862068965517 18.2 18 2 abnormal channel response 0.854284238252227 0.994865188507685 0.490261346768027 0.272727272727273 18.2 18 2 abnormal behavioral response to xenobiotic 0.865103262916633 1 0.47305919424985 0.263157894736842 18.2 18 2 abnormal retinal cone cell morphology 0.884085523710635 1 0.468945636038982 0.260869565217391 18.2 18 2 brain inflammation 0.89482419510126 1 0.449406234537358 0.25 18.2 18 2 decreased acute inflammation 0.92840618174395 1 0.431429985155863 0.24 18.2 18 2 heart hyperplasia 0.000182136540669297 0.00239084245337666 1.60273131809115 1 18.5 18 5 increased neuronal precursor cell number 0.000182136540669297 0.00239084245337666 1.60273131809115 1 18.5 18 5 decreased platelet dense granule number 0.000182136540669297 0.00239084245337666 1.60273131809115 1 18.5 18 5 failure of vascular branching 0.000474231760581904 0.00528991706030262 1.60273131809115 1 18.5 18 5 increased sensitivity to skin irradiation 0.000474231760581904 0.00528991706030262 1.60273131809115 1 18.5 18 5 early eyelid opening 0.000474231760581904 0.00528991706030262 1.60273131809115 1 18.5 18 5 liver cysts 0.000474231760581904 0.00528991706030262 1.60273131809115 1 18.5 18 5 abnormal extraembryonic tissue physiology 0.000474231760581904 0.00528991706030262 1.60273131809115 1 18.5 18 5 accumulation of giant lysosomes in kidney/renal tubule cells 0.000474231760581904 0.00528991706030262 1.60273131809115 1 18.5 18 5 abnormal cerebellum deep nucleus morphology 0.000474231760581904 0.00528991706030262 1.60273131809115 1 18.5 18 5 broad head 0.00123470627340573 0.011589931528667 1.60273131809115 1 18.5 18 5 polyphalangy 0.00123470627340573 0.011589931528667 1.60273131809115 1 18.5 18 5 abnormal brain ventricular system morphology 0.00123470627340573 0.011589931528667 1.60273131809115 1 18.5 18 5 abnormal talus morphology 0.00123470627340573 0.011589931528667 1.60273131809115 1 18.5 18 5 ductus venosus stenosis 0.00123470627340573 0.011589931528667 1.60273131809115 1 18.5 18 5 abnormal lacrimal gland physiology 0.00321452006304693 0.0249488881648339 1.60273131809115 1 18.5 18 5 delayed brain development 0.00321452006304693 0.0249488881648339 1.60273131809115 1 18.5 18 5 non-obstructive hydrocephaly 0.00321452006304693 0.0249488881648339 1.60273131809115 1 18.5 18 5 abnormal hippocampal fimbria morphology 0.00321452006304693 0.0249488881648339 1.60273131809115 1 18.5 18 5 absent parietal bone 0.00321452006304693 0.0249488881648339 1.60273131809115 1 18.5 18 5 decreased prostate gland weight 0.00321452006304693 0.0249488881648339 1.60273131809115 1 18.5 18 5 decreased platelet ADP level 0.00321452006304693 0.0249488881648339 1.60273131809115 1 18.5 18 5 abnormal eyelid development 0.00321452006304693 0.0249488881648339 1.60273131809115 1 18.5 18 5 decreased macrophage nitric oxide production 0.00321452006304693 0.0249488881648339 1.60273131809115 1 18.5 18 5 delayed limb development 0.00321452006304693 0.0249488881648339 1.60273131809115 1 18.5 18 5 abnormal vertebral artery origin 0.00321452006304693 0.0249488881648339 1.60273131809115 1 18.5 18 5 abnormal pineal gland morphology 0.00836850917326648 0.0516265641374548 1.60273131809115 1 18.5 18 5 decreased sensitivity to skin irradiation 0.00836850917326648 0.0516265641374548 1.60273131809115 1 18.5 18 5 corneal scarring 0.00836850917326648 0.0516265641374548 1.60273131809115 1 18.5 18 5 increased hepatic hemangioma incidence 0.00836850917326648 0.0516265641374548 1.60273131809115 1 18.5 18 5 increased urine microalbumin level 0.00836850917326648 0.0516265641374548 1.60273131809115 1 18.5 18 5 gastric polyps 0.00836850917326648 0.0516265641374548 1.60273131809115 1 18.5 18 5 ischuria 0.00836850917326648 0.0516265641374548 1.60273131809115 1 18.5 18 5 abnormal response to vitamins 0.00836850917326648 0.0516265641374548 1.60273131809115 1 18.5 18 5 increased heart right ventricle weight 0.00836850917326648 0.0516265641374548 1.60273131809115 1 18.5 18 5 absent frontal bone 0.00836850917326648 0.0516265641374548 1.60273131809115 1 18.5 18 5 corneal deposits 0.00836850917326648 0.0516265641374548 1.60273131809115 1 18.5 18 5 increased placenta apoptosis 0.00836850917326648 0.0516265641374548 1.60273131809115 1 18.5 18 5 abnormal calcaneum morphology 0.00836850917326648 0.0516265641374548 1.60273131809115 1 18.5 18 5 increased response to stress-induced hyperthermia 0.00836850917326648 0.0516265641374548 1.60273131809115 1 18.5 18 5 increased mammary gland epithelial cell proliferation 0.00836850917326648 0.0516265641374548 1.60273131809115 1 18.5 18 5 leptocytosis 0.00836850917326648 0.0516265641374548 1.60273131809115 1 18.5 18 5 increased T follicular helper cell number 0.00836850917326648 0.0516265641374548 1.60273131809115 1 18.5 18 5 increased thyroid carcinoma incidence 0.00836850917326648 0.0516265641374548 1.60273131809115 1 18.5 18 5 decreased heart left ventricle size 0.00836850917326648 0.0516265641374548 1.60273131809115 1 18.5 18 5 enlarged aortic valve 0.00836850917326648 0.0516265641374548 1.60273131809115 1 18.5 18 5 abnormal paranode morphology 0.00836850917326648 0.0516265641374548 1.60273131809115 1 18.5 18 5 increased Schwann cell number 0.00836850917326648 0.0516265641374548 1.60273131809115 1 18.5 18 5 pale lung 0.00836850917326648 0.0516265641374548 1.60273131809115 1 18.5 18 5 cerebral edema 0.00836850917326648 0.0516265641374548 1.60273131809115 1 18.5 18 5 delayed optic fissure closure 0.00836850917326648 0.0516265641374548 1.60273131809115 1 18.5 18 5 decreased small intestinal villus height 0.00836850917326648 0.0516265641374548 1.60273131809115 1 18.5 18 5 increased skin tumor incidence 1.61197664840798e-07 4.77356180108911e-06 1.52259475218659 0.95 18.5 18 5 increased hemangioma incidence 3.56829778925963e-05 0.000551313090110766 1.48825050965606 0.928571428571429 18.5 18 5 split sternum 3.56829778925963e-05 0.000551313090110766 1.48825050965606 0.928571428571429 18.5 18 5 increased thymocyte apoptosis 1.37085480607534e-08 5.05185382238875e-07 1.4794442936226 0.923076923076923 18.5 18 5 decreased red blood cell distribution width 0.000208880176929729 0.00268521674476848 1.46917037491688 0.916666666666667 18.5 18 5 increased fibrosarcoma incidence 0.000208880176929729 0.00268521674476848 1.46917037491688 0.916666666666667 18.5 18 5 abnormal sphenoid bone morphology 0.00050081543107621 0.00544008028297849 1.45702847099195 0.909090909090909 18.5 18 5 delayed hepatic development 0.00050081543107621 0.00544008028297849 1.45702847099195 0.909090909090909 18.5 18 5 loss of cortex neurons 0.00050081543107621 0.00544008028297849 1.45702847099195 0.909090909090909 18.5 18 5 abnormal palate development 0.00050081543107621 0.00544008028297849 1.45702847099195 0.909090909090909 18.5 18 5 aorta dilation 0.00050081543107621 0.00544008028297849 1.45702847099195 0.909090909090909 18.5 18 5 abnormal pericardium morphology 2.54461493033589e-06 5.65154432072368e-05 1.44245818628203 0.9 18.5 18 5 increased mammary adenocarcinoma incidence 2.54461493033589e-06 5.65154432072368e-05 1.44245818628203 0.9 18.5 18 5 abnormal mammary gland physiology 0.00119182225528627 0.0112939347048556 1.44245818628203 0.9 18.5 18 5 abnormal neuron specification 0.00119182225528627 0.0112939347048556 1.44245818628203 0.9 18.5 18 5 impaired basement membrane formation 0.00119182225528627 0.0112939347048556 1.44245818628203 0.9 18.5 18 5 increased heart rate variability 0.00119182225528627 0.0112939347048556 1.44245818628203 0.9 18.5 18 5 fusion of atlas and odontoid process 0.00119182225528627 0.0112939347048556 1.44245818628203 0.9 18.5 18 5 abnormal adaptive thermogenesis 0.00119182225528627 0.0112939347048556 1.44245818628203 0.9 18.5 18 5 lethality during fetal growth through weaning, complete penetrance 0.00119182225528627 0.0112939347048556 1.44245818628203 0.9 18.5 18 5 increased fatty acid oxidation 0.00119182225528627 0.0112939347048556 1.44245818628203 0.9 18.5 18 5 increased liver adenoma incidence 5.9867550438409e-06 0.000120097202996405 1.43402275829208 0.894736842105263 18.5 18 5 increased effector memory CD4-positive, alpha-beta T cell number 1.40080289452511e-05 0.000244526119307454 1.42465006052546 0.888888888888889 18.5 18 5 increased effector memory CD8-positive, alpha-beta T cell number 1.40080289452511e-05 0.000244526119307454 1.42465006052546 0.888888888888889 18.5 18 5 decreased level of surface class I molecules 0.00281099351988275 0.0228882041921714 1.42465006052546 0.888888888888889 18.5 18 5 increased pheochromocytoma incidence 0.00281099351988275 0.0228882041921714 1.42465006052546 0.888888888888889 18.5 18 5 positive geotaxis 0.00281099351988275 0.0228882041921714 1.42465006052546 0.888888888888889 18.5 18 5 shortened ST segment 0.00281099351988275 0.0228882041921714 1.42465006052546 0.888888888888889 18.5 18 5 symmetric azygos veins 0.00281099351988275 0.0228882041921714 1.42465006052546 0.888888888888889 18.5 18 5 increased fibroblast apoptosis 1.29763410597671e-08 4.8513537456017e-07 1.40238990332975 0.875 18.5 18 5 abnormal vagus ganglion morphology 0.0065580278631725 0.0440299441555778 1.40238990332975 0.875 18.5 18 5 colon polyps 0.0065580278631725 0.0440299441555778 1.40238990332975 0.875 18.5 18 5 abnormal eyelid aperture 0.0065580278631725 0.0440299441555778 1.40238990332975 0.875 18.5 18 5 elevated level of mitotic sister chromatid exchange 0.0065580278631725 0.0440299441555778 1.40238990332975 0.875 18.5 18 5 abnormal kidney epithelium morphology 0.0065580278631725 0.0440299441555778 1.40238990332975 0.875 18.5 18 5 craniofacial phenotype 0.0065580278631725 0.0440299441555778 1.40238990332975 0.875 18.5 18 5 pleural effusion 0.0065580278631725 0.0440299441555778 1.40238990332975 0.875 18.5 18 5 abnormal hepatic vein morphology 0.0065580278631725 0.0440299441555778 1.40238990332975 0.875 18.5 18 5 decreased alveolar lamellar body number 0.0065580278631725 0.0440299441555778 1.40238990332975 0.875 18.5 18 5 abnormal maxillary prominence morphology 0.0065580278631725 0.0440299441555778 1.40238990332975 0.875 18.5 18 5 impaired neuron differentiation 0.0065580278631725 0.0440299441555778 1.40238990332975 0.875 18.5 18 5 decreased cranium length 0.0065580278631725 0.0440299441555778 1.40238990332975 0.875 18.5 18 5 absent hypoglossal canal 0.0065580278631725 0.0440299441555778 1.40238990332975 0.875 18.5 18 5 abnormal umbilical vein topology 0.0065580278631725 0.0440299441555778 1.40238990332975 0.875 18.5 18 5 increased brain apoptosis 0.0065580278631725 0.0440299441555778 1.40238990332975 0.875 18.5 18 5 abnormal hematopoietic stem cell physiology 2.20728777851462e-06 5.06048695765449e-05 1.39367940703578 0.869565217391304 18.5 18 5 abnormal erythrocyte physiology 1.13550478895727e-05 0.00020175486875223 1.37376970122098 0.857142857142857 18.5 18 5 absent olfactory bulb 0.000391885244342186 0.00449223292765524 1.37376970122098 0.857142857142857 18.5 18 5 testis degeneration 0.000391885244342186 0.00449223292765524 1.37376970122098 0.857142857142857 18.5 18 5 asymmetric rib joints 0.0150934028008942 0.0810903660199229 1.37376970122098 0.857142857142857 18.5 18 5 skin photosensitivity 0.0150934028008942 0.0810903660199229 1.37376970122098 0.857142857142857 18.5 18 5 abnormal tumor incidence 0.0150934028008942 0.0810903660199229 1.37376970122098 0.857142857142857 18.5 18 5 decreased cholesterol efflux 0.0150934028008942 0.0810903660199229 1.37376970122098 0.857142857142857 18.5 18 5 decreased cardiomyocyte apoptosis 0.0150934028008942 0.0810903660199229 1.37376970122098 0.857142857142857 18.5 18 5 aorta coarctation 0.0150934028008942 0.0810903660199229 1.37376970122098 0.857142857142857 18.5 18 5 anuria 0.0150934028008942 0.0810903660199229 1.37376970122098 0.857142857142857 18.5 18 5 retinal pigment epithelium atrophy 0.0150934028008942 0.0810903660199229 1.37376970122098 0.857142857142857 18.5 18 5 decreased brain cholesterol level 0.0150934028008942 0.0810903660199229 1.37376970122098 0.857142857142857 18.5 18 5 abnormal T wave 0.0150934028008942 0.0810903660199229 1.37376970122098 0.857142857142857 18.5 18 5 increased circulating lactate dehydrogenase level 0.0150934028008942 0.0810903660199229 1.37376970122098 0.857142857142857 18.5 18 5 parturition failure 0.0150934028008942 0.0810903660199229 1.37376970122098 0.857142857142857 18.5 18 5 vertebral transformation 2.47607453630439e-11 1.52079886643387e-09 1.36899966753619 0.854166666666667 18.5 18 5 absent myocardial trabeculae 0.000881591562280714 0.00889638544086521 1.35615726915405 0.846153846153846 18.5 18 5 abnormal soleus morphology 0.000881591562280714 0.00889638544086521 1.35615726915405 0.846153846153846 18.5 18 5 anal atresia 0.000881591562280714 0.00889638544086521 1.35615726915405 0.846153846153846 18.5 18 5 absent hypoglossal nerve 0.000881591562280714 0.00889638544086521 1.35615726915405 0.846153846153846 18.5 18 5 abnormal spongiotrophoblast layer morphology 1.19885042993822e-07 3.65102726502928e-06 1.3523045496394 0.84375 18.5 18 5 increased liver cholesterol level 5.6788156419439e-05 0.000828507560664835 1.34966847839254 0.842105263157895 18.5 18 5 embryonic lethality between implantation and somite formation, incomplete penetrance 5.6788156419439e-05 0.000828507560664835 1.34966847839254 0.842105263157895 18.5 18 5 small heart 2.07937339028847e-10 1.07759193923803e-08 1.33560943174262 0.833333333333333 18.5 18 5 abnormal lysosome morphology 4.08128545324436e-08 1.38125136938032e-06 1.33560943174262 0.833333333333333 18.5 18 5 increased papilloma incidence 0.00196049170180861 0.0170514793994717 1.33560943174262 0.833333333333333 18.5 18 5 abnormal embryonic growth/weight/body size 0.00196049170180861 0.0170514793994717 1.33560943174262 0.833333333333333 18.5 18 5 abnormal rostral-caudal body axis extension 0.00196049170180861 0.0170514793994717 1.33560943174262 0.833333333333333 18.5 18 5 hematuria 0.00196049170180861 0.0170514793994717 1.33560943174262 0.833333333333333 18.5 18 5 abnormal thymus corticomedullary boundary morphology 0.00196049170180861 0.0170514793994717 1.33560943174262 0.833333333333333 18.5 18 5 persistent right dorsal aorta 0.00196049170180861 0.0170514793994717 1.33560943174262 0.833333333333333 18.5 18 5 echinocytosis 0.0341384547243642 0.15224917440951 1.33560943174262 0.833333333333333 18.5 18 5 hemoglobinuria 0.0341384547243642 0.15224917440951 1.33560943174262 0.833333333333333 18.5 18 5 increased embryo size 0.0341384547243642 0.15224917440951 1.33560943174262 0.833333333333333 18.5 18 5 absent ectoplacental cone 0.0341384547243642 0.15224917440951 1.33560943174262 0.833333333333333 18.5 18 5 reduced NMDA-mediated synaptic currents 0.0341384547243642 0.15224917440951 1.33560943174262 0.833333333333333 18.5 18 5 abnormal pulmonary ventilation 0.0341384547243642 0.15224917440951 1.33560943174262 0.833333333333333 18.5 18 5 increased post-tetanic potentiation 0.0341384547243642 0.15224917440951 1.33560943174262 0.833333333333333 18.5 18 5 acidemia 0.0341384547243642 0.15224917440951 1.33560943174262 0.833333333333333 18.5 18 5 bile duct inflammation 0.0341384547243642 0.15224917440951 1.33560943174262 0.833333333333333 18.5 18 5 decreased liver function 0.0341384547243642 0.15224917440951 1.33560943174262 0.833333333333333 18.5 18 5 abnormal milk ejection 0.0341384547243642 0.15224917440951 1.33560943174262 0.833333333333333 18.5 18 5 shortened QT interval 0.0341384547243642 0.15224917440951 1.33560943174262 0.833333333333333 18.5 18 5 abnormal cholesterol level 0.0341384547243642 0.15224917440951 1.33560943174262 0.833333333333333 18.5 18 5 absent cochlear nerve compound action potential 0.0341384547243642 0.15224917440951 1.33560943174262 0.833333333333333 18.5 18 5 delayed chorioallantoic fusion 0.0341384547243642 0.15224917440951 1.33560943174262 0.833333333333333 18.5 18 5 increased urine uric acid level 0.0341384547243642 0.15224917440951 1.33560943174262 0.833333333333333 18.5 18 5 abnormal neural crest cell morphology 0.0341384547243642 0.15224917440951 1.33560943174262 0.833333333333333 18.5 18 5 visceral vascular congestion 0.0341384547243642 0.15224917440951 1.33560943174262 0.833333333333333 18.5 18 5 abnormal orbit morphology 0.0341384547243642 0.15224917440951 1.33560943174262 0.833333333333333 18.5 18 5 abnormal heart right ventricle outflow tract morphology 0.0341384547243642 0.15224917440951 1.33560943174262 0.833333333333333 18.5 18 5 absent third pharyngeal arch 0.0341384547243642 0.15224917440951 1.33560943174262 0.833333333333333 18.5 18 5 thick myocardium 0.0341384547243642 0.15224917440951 1.33560943174262 0.833333333333333 18.5 18 5 abnormal intestinal enteroendocrine cell morphology 0.0341384547243642 0.15224917440951 1.33560943174262 0.833333333333333 18.5 18 5 abnormal mandibular prominence morphology 0.0341384547243642 0.15224917440951 1.33560943174262 0.833333333333333 18.5 18 5 ectopic ureteric bud 0.0341384547243642 0.15224917440951 1.33560943174262 0.833333333333333 18.5 18 5 abnormal Wolffian duct connection 0.0341384547243642 0.15224917440951 1.33560943174262 0.833333333333333 18.5 18 5 ectopic bone 0.0341384547243642 0.15224917440951 1.33560943174262 0.833333333333333 18.5 18 5 incomplete embryo turning 1.11447725091346e-11 7.39269909772594e-10 1.3215503850927 0.824561403508772 18.5 18 5 increased hepatocellular carcinoma incidence 1.11447725091346e-11 7.39269909772594e-10 1.3215503850927 0.824561403508772 18.5 18 5 abnormal dorsal-ventral axis patterning 0.00027436697374521 0.00337865270886737 1.31989637960447 0.823529411764706 18.5 18 5 abnormal lysosome physiology 3.98517427072231e-05 0.000610038215287492 1.31132562389276 0.818181818181818 18.5 18 5 increased adenoma incidence 3.98517427072231e-05 0.000610038215287492 1.31132562389276 0.818181818181818 18.5 18 5 premature suture closure 0.00430135296423152 0.0317025644400768 1.31132562389276 0.818181818181818 18.5 18 5 abnormal proximal-distal axis patterning 0.00430135296423152 0.0317025644400768 1.31132562389276 0.818181818181818 18.5 18 5 patent ductus arteriosus 0.00430135296423152 0.0317025644400768 1.31132562389276 0.818181818181818 18.5 18 5 abnormal radial glial cell morphology 0.00430135296423152 0.0317025644400768 1.31132562389276 0.818181818181818 18.5 18 5 pharyngeal arch hypoplasia 0.00430135296423152 0.0317025644400768 1.31132562389276 0.818181818181818 18.5 18 5 abnormal dorsal-ventral polarity of the somites 0.00430135296423152 0.0317025644400768 1.31132562389276 0.818181818181818 18.5 18 5 decreased embryonic cilium length 0.00430135296423152 0.0317025644400768 1.31132562389276 0.818181818181818 18.5 18 5 thin hypoglossal nerve 0.00430135296423152 0.0317025644400768 1.31132562389276 0.818181818181818 18.5 18 5 reduced sympathetic cervical ganglion size 0.00430135296423152 0.0317025644400768 1.31132562389276 0.818181818181818 18.5 18 5 decreased total retina thickness 6.36383161255309e-08 2.04258466273881e-06 1.30749133844278 0.815789473684211 18.5 18 5 abnormal fetal cardiomyocyte proliferation 5.91910141344675e-06 0.000119220767335618 1.30592922214834 0.814814814814815 18.5 18 5 decreased creatinine clearance 0.000593777322615894 0.0062757412619223 1.30221919594906 0.8125 18.5 18 5 impaired somite development 0.000593777322615894 0.0062757412619223 1.30221919594906 0.8125 18.5 18 5 increased muscle cell glucose uptake 8.55751788262558e-05 0.00118041486634824 1.29744916226426 0.80952380952381 18.5 18 5 abnormal trophoblast giant cell morphology 2.88685321443436e-07 7.89126084714886e-06 1.2910891173512 0.805555555555556 18.5 18 5 abnormal cell differentiation 4.42393016598103e-08 1.47711762253394e-06 1.29000325602458 0.804878048780488 18.5 18 5 abnormal liver development 6.09292265820744e-07 1.53092374871626e-05 1.28218505447292 0.8 18.5 18 5 macrocytosis 0.00126954409914596 0.0118498722199834 1.28218505447292 0.8 18.5 18 5 abnormal trophectoderm morphology 0.00126954409914596 0.0118498722199834 1.28218505447292 0.8 18.5 18 5 abnormal branching involved in lung morphogenesis 0.00126954409914596 0.0118498722199834 1.28218505447292 0.8 18.5 18 5 abnormal tibialis anterior morphology 0.00928767857826871 0.0560075162750144 1.28218505447292 0.8 18.5 18 5 bifid ureter 0.00928767857826871 0.0560075162750144 1.28218505447292 0.8 18.5 18 5 abnormal respiratory conducting tube morphology 0.00928767857826871 0.0560075162750144 1.28218505447292 0.8 18.5 18 5 tachypnea 0.00928767857826871 0.0560075162750144 1.28218505447292 0.8 18.5 18 5 vascular smooth muscle hyperplasia 0.00928767857826871 0.0560075162750144 1.28218505447292 0.8 18.5 18 5 decreased transitional stage T2 B cell number 0.00928767857826871 0.0560075162750144 1.28218505447292 0.8 18.5 18 5 abnormal cerebellar granule cell migration 0.00928767857826871 0.0560075162750144 1.28218505447292 0.8 18.5 18 5 increased serotonin level 0.00928767857826871 0.0560075162750144 1.28218505447292 0.8 18.5 18 5 increased circulating fructosamine level 0.00928767857826871 0.0560075162750144 1.28218505447292 0.8 18.5 18 5 abnormal placenta morphology 6.8653740383742e-14 6.21004288016575e-12 1.27812750683218 0.79746835443038 18.5 18 5 increased mortality induced by gamma-irradiation 8.42765565736945e-06 0.000158217309039294 1.27113173503781 0.793103448275862 18.5 18 5 abnormal outer ear morphology 8.42765565736945e-06 0.000158217309039294 1.27113173503781 0.793103448275862 18.5 18 5 enlarged kidney 1.51091732151661e-09 6.77190421130192e-08 1.27008896905336 0.792452830188679 18.5 18 5 abnormal vitelline vasculature morphology 5.03599713646623e-19 1.04392023974665e-16 1.26824826040256 0.791304347826087 18.5 18 5 abnormal cell morphology 1.04306483885256e-18 1.92194354566351e-16 1.26531419849301 0.789473684210526 18.5 18 5 small superior vagus ganglion 0.000382800559993328 0.00440840922677501 1.26531419849301 0.789473684210526 18.5 18 5 abnormal digestive system development 0.000382800559993328 0.00440840922677501 1.26531419849301 0.789473684210526 18.5 18 5 abnormal blastocyst morphology 0.000382800559993328 0.00440840922677501 1.26531419849301 0.789473684210526 18.5 18 5 increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 0.000382800559993328 0.00440840922677501 1.26531419849301 0.789473684210526 18.5 18 5 abnormal blood flow velocity 0.00267718139472198 0.0221982957312364 1.2592888927859 0.785714285714286 18.5 18 5 irregularly shaped pupil 0.00267718139472198 0.0221982957312364 1.2592888927859 0.785714285714286 18.5 18 5 abnormal adrenal gland secretion 0.00267718139472198 0.0221982957312364 1.2592888927859 0.785714285714286 18.5 18 5 increased lactate dehydrogenase level 0.00267718139472198 0.0221982957312364 1.2592888927859 0.785714285714286 18.5 18 5 abnormal ventral body wall morphology 0.00267718139472198 0.0221982957312364 1.2592888927859 0.785714285714286 18.5 18 5 premature hair loss 0.00267718139472198 0.0221982957312364 1.2592888927859 0.785714285714286 18.5 18 5 pale liver 2.62751861820219e-12 1.86741501793656e-10 1.25619481688225 0.783783783783784 18.5 18 5 pale yolk sac 1.3511799122235e-13 1.1589862178124e-11 1.25515103224005 0.783132530120482 18.5 18 5 abnormal neural tube closure 1.3511799122235e-13 1.1589862178124e-11 1.25515103224005 0.783132530120482 18.5 18 5 pancreatic islet hyperplasia 5.49798685960671e-06 0.000111188961896518 1.25213384225871 0.78125 18.5 18 5 abnormal erythropoiesis 1.177521959586e-16 1.54162414445799e-14 1.25165683889023 0.780952380952381 18.5 18 5 increased gastrointestinal tumor incidence 0.000795673168594118 0.00809503888293607 1.24656880295978 0.777777777777778 18.5 18 5 abnormal metanephric mesenchyme morphology 0.000795673168594118 0.00809503888293607 1.24656880295978 0.777777777777778 18.5 18 5 abnormal hypoglossal nerve topology 0.000795673168594118 0.00809503888293607 1.24656880295978 0.777777777777778 18.5 18 5 distorted hair follicle pattern 0.0196726480646866 0.10184331334216 1.24656880295978 0.777777777777778 18.5 18 5 dilated uterus 0.0196726480646866 0.10184331334216 1.24656880295978 0.777777777777778 18.5 18 5 pancreas cysts 0.0196726480646866 0.10184331334216 1.24656880295978 0.777777777777778 18.5 18 5 premature neuronal precursor differentiation 0.0196726480646866 0.10184331334216 1.24656880295978 0.777777777777778 18.5 18 5 decreased fear-related response 0.0196726480646866 0.10184331334216 1.24656880295978 0.777777777777778 18.5 18 5 abnormal thymus physiology 0.0196726480646866 0.10184331334216 1.24656880295978 0.777777777777778 18.5 18 5 decreased cellular sensitivity to ionizing radiation 0.0196726480646866 0.10184331334216 1.24656880295978 0.777777777777778 18.5 18 5 small scapula 0.0196726480646866 0.10184331334216 1.24656880295978 0.777777777777778 18.5 18 5 decreased transitional stage T1 B cell number 0.0196726480646866 0.10184331334216 1.24656880295978 0.777777777777778 18.5 18 5 axonal spheroids 0.0196726480646866 0.10184331334216 1.24656880295978 0.777777777777778 18.5 18 5 abnormal ventricle myocardium morphology 0.0196726480646866 0.10184331334216 1.24656880295978 0.777777777777778 18.5 18 5 iris coloboma 0.0196726480646866 0.10184331334216 1.24656880295978 0.777777777777778 18.5 18 5 fusion of atlas and occipital bones 0.0196726480646866 0.10184331334216 1.24656880295978 0.777777777777778 18.5 18 5 abnormal lung lobe morphology 0.0196726480646866 0.10184331334216 1.24656880295978 0.777777777777778 18.5 18 5 abnormal ductus venosus valve topology 0.0196726480646866 0.10184331334216 1.24656880295978 0.777777777777778 18.5 18 5 abnormal infrahyoid muscle connection 0.0196726480646866 0.10184331334216 1.24656880295978 0.777777777777778 18.5 18 5 increased cardiac muscle glycogen level 0.0196726480646866 0.10184331334216 1.24656880295978 0.777777777777778 18.5 18 5 decreased fatty acid oxidation 0.0196726480646866 0.10184331334216 1.24656880295978 0.777777777777778 18.5 18 5 increased endoplasmic reticulum stress 0.0196726480646866 0.10184331334216 1.24656880295978 0.777777777777778 18.5 18 5 inner cell mass degeneration 1.12736282846588e-05 0.000201026167441496 1.24082424626411 0.774193548387097 18.5 18 5 pale kidney 1.12736282846588e-05 0.000201026167441496 1.24082424626411 0.774193548387097 18.5 18 5 preaxial polydactyly 1.12736282846588e-05 0.000201026167441496 1.24082424626411 0.774193548387097 18.5 18 5 abnormal cell cycle 1.68305773639699e-17 2.61662882455469e-15 1.24037467226184 0.773913043478261 18.5 18 5 abnormal vascular branching morphogenesis 0.000241034861630966 0.00299642915431371 1.23847420034316 0.772727272727273 18.5 18 5 embryonic lethality before implantation, incomplete penetrance 0.000241034861630966 0.00299642915431371 1.23847420034316 0.772727272727273 18.5 18 5 decreased brain weight 2.77962568923002e-09 1.17191845795927e-07 1.23719610519317 0.771929824561403 18.5 18 5 embryonic lethality between implantation and somite formation, complete penetrance 3.26335984187514e-35 1.80391280148098e-32 1.23639273109888 0.771428571428571 18.5 18 5 increased carcinoma incidence 3.53292343234714e-06 7.4550650485096e-05 1.23639273109888 0.771428571428571 18.5 18 5 increased circulating serum albumin level 3.53292343234714e-06 7.4550650485096e-05 1.23639273109888 0.771428571428571 18.5 18 5 lethality throughout fetal growth and development, incomplete penetrance 4.77214836396572e-26 1.5827625407153e-23 1.23562526199206 0.770949720670391 18.5 18 5 liver hypoplasia 1.75980620222666e-08 6.29858694681846e-07 1.2328702446855 0.769230769230769 18.5 18 5 abnormal placenta vasculature 1.75980620222666e-08 6.29858694681846e-07 1.2328702446855 0.769230769230769 18.5 18 5 increased hepatocyte apoptosis 1.11249420970647e-06 2.71306798690671e-05 1.2328702446855 0.769230769230769 18.5 18 5 ventricular hypoplasia 7.39774077288847e-05 0.00104259944320454 1.2328702446855 0.769230769230769 18.5 18 5 increased foot pad pigmentation 0.00555682550023495 0.0387730811552158 1.2328702446855 0.769230769230769 18.5 18 5 abnormal grip strength 0.00555682550023495 0.0387730811552158 1.2328702446855 0.769230769230769 18.5 18 5 abnormal coping response 0.00555682550023495 0.0387730811552158 1.2328702446855 0.769230769230769 18.5 18 5 decreased mean corpuscular hemoglobin 1.84823273625152e-10 9.71482350336901e-09 1.22561806677558 0.764705882352941 18.5 18 5 aminoaciduria 0.00163186095644561 0.014707442496951 1.22561806677558 0.764705882352941 18.5 18 5 increased brain size 0.00163186095644561 0.014707442496951 1.22561806677558 0.764705882352941 18.5 18 5 increased hepatoma incidence 0.00163186095644561 0.014707442496951 1.22561806677558 0.764705882352941 18.5 18 5 abnormal trophoblast layer morphology 3.54725824792415e-08 1.20874039612484e-06 1.22561806677558 0.764705882352941 18.5 18 5 abnormal embryo turning 1.13069697388049e-08 4.29405911836293e-07 1.22390391563324 0.763636363636364 18.5 18 5 persistence of hyaloid vascular system 2.2451501812207e-06 5.12367988604265e-05 1.22313705854324 0.763157894736842 18.5 18 5 spina bifida 7.07841893217411e-07 1.75199672574956e-05 1.22112862330754 0.761904761904762 18.5 18 5 liver degeneration 0.000490441489021992 0.00541988570533376 1.22112862330754 0.761904761904762 18.5 18 5 failure to gastrulate 2.23992462770831e-07 6.22548883958036e-06 1.21946948115631 0.760869565217391 18.5 18 5 embryonic lethality between implantation and placentation, complete penetrance 2.23992462770831e-07 6.22548883958036e-06 1.21946948115631 0.760869565217391 18.5 18 5 spontaneous skin ulceration 0.000149679077996694 0.00199105190650682 1.21807580174927 0.76 18.5 18 5 abnormal preimplantation embryo development 0.000149679077996694 0.00199105190650682 1.21807580174927 0.76 18.5 18 5 small liver 2.43830167839385e-11 1.51631885625117e-09 1.21232240727407 0.756410256410256 18.5 18 5 liver fibrosis 1.4149036018065e-06 3.36801216219489e-05 1.21182124050794 0.75609756097561 18.5 18 5 increased neuron apoptosis 1.55238568729745e-11 1.00300244081881e-09 1.20699519016741 0.753086419753086 18.5 18 5 abnormal pharyngeal arch morphology 8.93744401596463e-06 0.000165292877246929 1.20204848856836 0.75 18.5 18 5 abnormal retinal blood vessel morphology 8.93744401596463e-06 0.000165292877246929 1.20204848856836 0.75 18.5 18 5 ocular hypertelorism 0.000299519297688645 0.00364329708068706 1.20204848856836 0.75 18.5 18 5 increased hemangiosarcoma incidence 0.000299519297688645 0.00364329708068706 1.20204848856836 0.75 18.5 18 5 increased body temperature 0.000299519297688645 0.00364329708068706 1.20204848856836 0.75 18.5 18 5 abnormal vascular regression 0.000985286481926163 0.0096682450642656 1.20204848856836 0.75 18.5 18 5 decreased myocardial infarction size 0.000985286481926163 0.0096682450642656 1.20204848856836 0.75 18.5 18 5 spleen atrophy 0.000985286481926163 0.0096682450642656 1.20204848856836 0.75 18.5 18 5 dilated vasculature 0.000985286481926163 0.0096682450642656 1.20204848856836 0.75 18.5 18 5 abnormal hair follicle orientation 0.00329684442873617 0.0253114213471642 1.20204848856836 0.75 18.5 18 5 disorganized yolk sac vascular plexus 0.00329684442873617 0.0253114213471642 1.20204848856836 0.75 18.5 18 5 intraventricular hemorrhage 0.00329684442873617 0.0253114213471642 1.20204848856836 0.75 18.5 18 5 increased intestinal adenocarcinoma incidence 0.00329684442873617 0.0253114213471642 1.20204848856836 0.75 18.5 18 5 kidney degeneration 0.00329684442873617 0.0253114213471642 1.20204848856836 0.75 18.5 18 5 abnormal pulmonary alveolus wall morphology 0.00329684442873617 0.0253114213471642 1.20204848856836 0.75 18.5 18 5 mesocardia 0.0113239367515002 0.0669080585970471 1.20204848856836 0.75 18.5 18 5 abnormal vascular endothelial cell development 0.0113239367515002 0.0669080585970471 1.20204848856836 0.75 18.5 18 5 increased osteosarcoma incidence 0.0113239367515002 0.0669080585970471 1.20204848856836 0.75 18.5 18 5 pale placenta 0.0113239367515002 0.0669080585970471 1.20204848856836 0.75 18.5 18 5 abnormal fatty acid level 0.0113239367515002 0.0669080585970471 1.20204848856836 0.75 18.5 18 5 decreased mammary gland epithelial cell proliferation 0.0113239367515002 0.0669080585970471 1.20204848856836 0.75 18.5 18 5 abnormal pulmonary valve cusp morphology 0.0113239367515002 0.0669080585970471 1.20204848856836 0.75 18.5 18 5 prenatal growth retardation 0.0113239367515002 0.0669080585970471 1.20204848856836 0.75 18.5 18 5 embryonic lethality between implantation and placentation, incomplete penetrance 0.0113239367515002 0.0669080585970471 1.20204848856836 0.75 18.5 18 5 clubfoot 0.0406995276140592 0.172617348576253 1.20204848856836 0.75 18.5 18 5 dermal cysts 0.0406995276140592 0.172617348576253 1.20204848856836 0.75 18.5 18 5 dry eyes 0.0406995276140592 0.172617348576253 1.20204848856836 0.75 18.5 18 5 absent eyelids 0.0406995276140592 0.172617348576253 1.20204848856836 0.75 18.5 18 5 preneoplasia 0.0406995276140592 0.172617348576253 1.20204848856836 0.75 18.5 18 5 abnormal thyroid physiology 0.0406995276140592 0.172617348576253 1.20204848856836 0.75 18.5 18 5 hypospadia 0.0406995276140592 0.172617348576253 1.20204848856836 0.75 18.5 18 5 abnormal perineum morphology 0.0406995276140592 0.172617348576253 1.20204848856836 0.75 18.5 18 5 increased cardiac output 0.0406995276140592 0.172617348576253 1.20204848856836 0.75 18.5 18 5 binucleate 0.0406995276140592 0.172617348576253 1.20204848856836 0.75 18.5 18 5 bowed fibula 0.0406995276140592 0.172617348576253 1.20204848856836 0.75 18.5 18 5 abnormal somite size 0.0406995276140592 0.172617348576253 1.20204848856836 0.75 18.5 18 5 abnormal vertebral body development 0.0406995276140592 0.172617348576253 1.20204848856836 0.75 18.5 18 5 abnormal olfactory tract morphology 0.0406995276140592 0.172617348576253 1.20204848856836 0.75 18.5 18 5 Sertoli cell hypoplasia 0.0406995276140592 0.172617348576253 1.20204848856836 0.75 18.5 18 5 stomach epithelial hyperplasia 0.0406995276140592 0.172617348576253 1.20204848856836 0.75 18.5 18 5 absent outer ear 0.0406995276140592 0.172617348576253 1.20204848856836 0.75 18.5 18 5 abnormal meiotic spindle morphology 0.0406995276140592 0.172617348576253 1.20204848856836 0.75 18.5 18 5 abnormal mitotic spindle assembly checkpoint 0.0406995276140592 0.172617348576253 1.20204848856836 0.75 18.5 18 5 abnormal base-excision repair 0.0406995276140592 0.172617348576253 1.20204848856836 0.75 18.5 18 5 abnormal sphingomyelin level 0.0406995276140592 0.172617348576253 1.20204848856836 0.75 18.5 18 5 abnormal frontonasal prominence morphology 0.0406995276140592 0.172617348576253 1.20204848856836 0.75 18.5 18 5 abnormal olfactory bulb mitral cell layer morphology 0.0406995276140592 0.172617348576253 1.20204848856836 0.75 18.5 18 5 decreased hippocampus pyramidal cell number 0.0406995276140592 0.172617348576253 1.20204848856836 0.75 18.5 18 5 decreased quadriceps weight 0.0406995276140592 0.172617348576253 1.20204848856836 0.75 18.5 18 5 myocardial trabeculae hypoplasia 0.0406995276140592 0.172617348576253 1.20204848856836 0.75 18.5 18 5 abnormal stomach position or orientation 0.0406995276140592 0.172617348576253 1.20204848856836 0.75 18.5 18 5 abnormal macrophage activation involved in immune response 0.0406995276140592 0.172617348576253 1.20204848856836 0.75 18.5 18 5 lethality during fetal growth through weaning, incomplete penetrance 0.0406995276140592 0.172617348576253 1.20204848856836 0.75 18.5 18 5 abnormal heart echocardiography feature 0.0406995276140592 0.172617348576253 1.20204848856836 0.75 18.5 18 5 increased cardiac stroke volume 0.0406995276140592 0.172617348576253 1.20204848856836 0.75 18.5 18 5 increased cornea thickness 0.0406995276140592 0.172617348576253 1.20204848856836 0.75 18.5 18 5 embryo cyst 0.0406995276140592 0.172617348576253 1.20204848856836 0.75 18.5 18 5 decreased basal metabolism 0.0406995276140592 0.172617348576253 1.20204848856836 0.75 18.5 18 5 kinked neural tube 8.90961438501662e-08 2.80540073199099e-06 1.20204848856836 0.75 18.5 18 5 premature aging 9.21468437054296e-05 0.00126638272771965 1.20204848856836 0.75 18.5 18 5 abnormal placenta labyrinth morphology 6.01462781806875e-11 3.40031515851046e-09 1.19697655401744 0.746835443037975 18.5 18 5 abnormal head morphology 5.57760356546878e-08 1.80185569728618e-06 1.1947633462134 0.745454545454545 18.5 18 5 small lung 1.75237963697872e-07 5.15863236329534e-06 1.19419196249929 0.745098039215686 18.5 18 5 increased cellular sensitivity to gamma-irradiation 5.51972826054619e-07 1.39933942260666e-05 1.19352332198277 0.74468085106383 18.5 18 5 abnormal cell nucleus morphology 5.51972826054619e-07 1.39933942260666e-05 1.19352332198277 0.74468085106383 18.5 18 5 abnormal vasculogenesis 1.74391034110588e-06 4.07321781549377e-05 1.19273028323062 0.744186046511628 18.5 18 5 increased rib number 1.17666258556008e-10 6.36293082952326e-09 1.19177456986265 0.743589743589744 18.5 18 5 kidney cysts 3.66207971399054e-10 1.78616142912774e-08 1.19121922290558 0.743243243243243 18.5 18 5 lethality throughout fetal growth and development, complete penetrance 1.0215167613489e-23 2.9009992873959e-21 1.18939534658343 0.742105263157895 18.5 18 5 abnormal mitochondrial ATP synthesis coupled electron transport 5.64093937491021e-05 0.000827836973161601 1.18912323600311 0.741935483870968 18.5 18 5 abnormal apoptosis 1.09033881964816e-07 3.36921467562086e-06 1.18720838377122 0.740740740740741 18.5 18 5 abnormal heart valve morphology 0.000181934422478697 0.00239084245337666 1.18720838377122 0.740740740740741 18.5 18 5 increased brain weight 0.000181934422478697 0.00239084245337666 1.18720838377122 0.740740740740741 18.5 18 5 increased B cell derived lymphoma incidence 3.42515647417724e-07 9.06917977890447e-06 1.18602117538745 0.74 18.5 18 5 embryonic lethality, complete penetrance 2.30197778970096e-38 1.63604850053747e-35 1.18571972122104 0.739811912225705 18.5 18 5 abnormal pulmonary artery morphology 0.000592189466365594 0.0062757412619223 1.18462749598041 0.739130434782609 18.5 18 5 decreased erythrocyte cell number 1.63465944623261e-19 3.69655942954873e-17 1.1841836490355 0.738853503184713 18.5 18 5 double outlet right ventricle 1.01133153803365e-13 8.98459714592396e-12 1.18332499186169 0.738317757009346 18.5 18 5 abnormal reproductive system morphology 3.40753205328486e-06 7.33873245242086e-05 1.18296835382918 0.738095238095238 18.5 18 5 impaired branching involved in ureteric bud morphogenesis 1.0803155926809e-05 0.000196152192466696 1.18095991859348 0.736842105263158 18.5 18 5 increased malignant tumor incidence 0.00195171647267634 0.0170514793994717 1.18095991859348 0.736842105263158 18.5 18 5 abnormal cochlear inner hair cell morphology 0.00195171647267634 0.0170514793994717 1.18095991859348 0.736842105263158 18.5 18 5 abnormal direction of heart looping 3.4401751712191e-05 0.000534839733650469 1.17847891036114 0.735294117647059 18.5 18 5 abnormal embryo size 3.9522968581733e-14 3.70993903196456e-12 1.17722742833243 0.734513274336283 18.5 18 5 increased tumor incidence 2.59007453785853e-15 2.99665600601074e-13 1.17619798343786 0.733870967741935 18.5 18 5 oxidative stress 1.78988280507461e-11 1.1416239686213e-09 1.17533629993351 0.733333333333333 18.5 18 5 vagina atresia 0.00654818395755602 0.0440299441555778 1.17533629993351 0.733333333333333 18.5 18 5 delayed intramembranous bone ossification 0.00654818395755602 0.0440299441555778 1.17533629993351 0.733333333333333 18.5 18 5 abnormal glial cell morphology 0.00654818395755602 0.0440299441555778 1.17533629993351 0.733333333333333 18.5 18 5 abnormal cerebral aqueduct morphology 0.00654818395755602 0.0440299441555778 1.17533629993351 0.733333333333333 18.5 18 5 corneal opacity 2.66702180263624e-09 1.14383047138925e-07 1.17383138789774 0.732394366197183 18.5 18 5 heart inflammation 0.000355155040152176 0.00422702470037578 1.17122673245122 0.730769230769231 18.5 18 5 increased leukemia incidence 0.000355155040152176 0.00422702470037578 1.17122673245122 0.730769230769231 18.5 18 5 abnormal Mullerian duct morphology 0.000355155040152176 0.00422702470037578 1.17122673245122 0.730769230769231 18.5 18 5 abnormal hepatocyte morphology 1.45826113464584e-13 1.20914152414384e-11 1.16956069158003 0.72972972972973 18.5 18 5 abnormal lung development 1.06363929656371e-10 5.81495109934555e-09 1.16905107907825 0.729411764705882 18.5 18 5 embryonic lethality between somite formation and embryo turning, complete penetrance 5.12027543669005e-09 2.10523721467215e-07 1.16770424603784 0.728571428571429 18.5 18 5 abnormal craniofacial morphology 1.38608916264879e-12 9.99390374518515e-11 1.1670373675421 0.728155339805825 18.5 18 5 abnormal basement membrane morphology 0.00115552582873139 0.0111194216594559 1.16562277679356 0.727272727272727 18.5 18 5 increased circulating creatine kinase level 0.00115552582873139 0.0111194216594559 1.16562277679356 0.727272727272727 18.5 18 5 abnormal thrombopoiesis 0.0225845468823679 0.110406146184543 1.16562277679356 0.727272727272727 18.5 18 5 abnormal glossopharyngeal ganglion morphology 0.0225845468823679 0.110406146184543 1.16562277679356 0.727272727272727 18.5 18 5 abnormal eye distance/ position 0.0225845468823679 0.110406146184543 1.16562277679356 0.727272727272727 18.5 18 5 abnormal bronchiole morphology 0.0225845468823679 0.110406146184543 1.16562277679356 0.727272727272727 18.5 18 5 impaired luteinization 0.0225845468823679 0.110406146184543 1.16562277679356 0.727272727272727 18.5 18 5 pathological neovascularization 0.0225845468823679 0.110406146184543 1.16562277679356 0.727272727272727 18.5 18 5 increased glycogen level 0.0225845468823679 0.110406146184543 1.16562277679356 0.727272727272727 18.5 18 5 palatal shelf hypoplasia 0.0225845468823679 0.110406146184543 1.16562277679356 0.727272727272727 18.5 18 5 common atrioventricular valve 0.0225845468823679 0.110406146184543 1.16562277679356 0.727272727272727 18.5 18 5 hypolactation 0.0225845468823679 0.110406146184543 1.16562277679356 0.727272727272727 18.5 18 5 abnormal vascular development 1.59028019245513e-08 5.81738526284136e-07 1.16562277679356 0.727272727272727 18.5 18 5 enlarged pericardium 6.65585978764481e-05 0.000951520185158992 1.16562277679356 0.727272727272727 18.5 18 5 increased cardiomyocyte apoptosis 6.65585978764481e-05 0.000951520185158992 1.16562277679356 0.727272727272727 18.5 18 5 decreased embryo size 1.46761120521551e-52 1.46027314918943e-49 1.16348905309127 0.725941422594142 18.5 18 5 pericardial effusion 4.94353412163946e-08 1.60745635654616e-06 1.16327273087261 0.725806451612903 18.5 18 5 increased bone mineral content 5.31088414113415e-13 4.12838259408475e-11 1.16161260668991 0.724770642201835 18.5 18 5 decreased trophoblast giant cell number 0.000212802213824133 0.00272157072949887 1.16059854068669 0.724137931034483 18.5 18 5 embryonic lethality during organogenesis, complete penetrance 1.90361270318571e-60 2.36761829958722e-57 1.1591181854052 0.723214285714286 18.5 18 5 abnormal maxilla morphology 4.79195380905236e-07 1.24816597905945e-05 1.15752817417694 0.722222222222222 18.5 18 5 abnormal cell adhesion 4.79195380905236e-07 1.24816597905945e-05 1.15752817417694 0.722222222222222 18.5 18 5 delayed kidney development 0.0038059492048595 0.0287323175935903 1.15752817417694 0.722222222222222 18.5 18 5 abnormal bile duct morphology 0.0038059492048595 0.0287323175935903 1.15752817417694 0.722222222222222 18.5 18 5 decreased cellular sensitivity to gamma-irradiation 0.0038059492048595 0.0287323175935903 1.15752817417694 0.722222222222222 18.5 18 5 abnormal body wall morphology 0.0038059492048595 0.0287323175935903 1.15752817417694 0.722222222222222 18.5 18 5 increased adipocyte glucose uptake 0.0038059492048595 0.0287323175935903 1.15752817417694 0.722222222222222 18.5 18 5 increased circulating creatinine level 2.37980232823692e-10 1.18395165829787e-08 1.15545746187966 0.720930232558139 18.5 18 5 kidney failure 7.70522147641389e-06 0.000145754664810491 1.15545746187966 0.720930232558139 18.5 18 5 abnormal interventricular septum morphology 1.49464607164821e-06 3.52410625898098e-05 1.15396654902563 0.72 18.5 18 5 abnormal keratinocyte physiology 0.000684822719753663 0.00709790214744682 1.15396654902563 0.72 18.5 18 5 abnormal facial morphology 2.92317654833426e-07 7.94688706446063e-06 1.15284182529363 0.719298245614035 18.5 18 5 abnormal muscle physiology 1.46226398458044e-10 7.82232615407277e-09 1.15252589166105 0.719101123595506 18.5 18 5 kidney cortex cysts 0.000127476432343946 0.00173277390959326 1.15196313487801 0.71875 18.5 18 5 abnormal allantois morphology 4.66850681322389e-06 9.55795119168265e-05 1.14978551080452 0.717391304347826 18.5 18 5 abnormal kidney development 1.78147669632384e-07 5.2134391554183e-06 1.14862411129865 0.716666666666667 18.5 18 5 increased circulating alkaline phosphatase level 9.66960689996457e-18 1.60354314424412e-15 1.14763477097885 0.716049382716049 18.5 18 5 pallor 7.37829323242082e-19 1.41180803197283e-16 1.14480808435082 0.714285714285714 18.5 18 5 polydactyly 3.37460102896964e-11 2.02272772519566e-09 1.14480808435082 0.714285714285714 18.5 18 5 decreased triglyceride level 7.63735998452615e-05 0.00107030608233852 1.14480808435082 0.714285714285714 18.5 18 5 abnormal scapula morphology 0.00222239896418659 0.0189133233664503 1.14480808435082 0.714285714285714 18.5 18 5 abnormal eye pigmentation 0.00222239896418659 0.0189133233664503 1.14480808435082 0.714285714285714 18.5 18 5 trunk curl 0.00222239896418659 0.0189133233664503 1.14480808435082 0.714285714285714 18.5 18 5 abnormal hematopoietic system physiology 0.00222239896418659 0.0189133233664503 1.14480808435082 0.714285714285714 18.5 18 5 left pulmonary isomerism 0.00222239896418659 0.0189133233664503 1.14480808435082 0.714285714285714 18.5 18 5 embryonic lethality at implantation, complete penetrance 0.00222239896418659 0.0189133233664503 1.14480808435082 0.714285714285714 18.5 18 5 lymphoid hyperplasia 0.000406403369411864 0.00463728615326611 1.14480808435082 0.714285714285714 18.5 18 5 subcutaneous edema 0.000406403369411864 0.00463728615326611 1.14480808435082 0.714285714285714 18.5 18 5 midline facial cleft 0.0127559357640173 0.0740499188167866 1.14480808435082 0.714285714285714 18.5 18 5 translucent skin 0.0127559357640173 0.0740499188167866 1.14480808435082 0.714285714285714 18.5 18 5 amyloid beta deposits 0.0127559357640173 0.0740499188167866 1.14480808435082 0.714285714285714 18.5 18 5 failure of zygotic cell division 0.0127559357640173 0.0740499188167866 1.14480808435082 0.714285714285714 18.5 18 5 abnormal vascular endothelial cell migration 0.0127559357640173 0.0740499188167866 1.14480808435082 0.714285714285714 18.5 18 5 lysosomal protein accumulation 0.0127559357640173 0.0740499188167866 1.14480808435082 0.714285714285714 18.5 18 5 abnormal glucose tolerance 0.0127559357640173 0.0740499188167866 1.14480808435082 0.714285714285714 18.5 18 5 abnormal renal tubule epithelial cell primary cilium morphology 0.0127559357640173 0.0740499188167866 1.14480808435082 0.714285714285714 18.5 18 5 multiple persisting craniopharyngeal ducts 0.0127559357640173 0.0740499188167866 1.14480808435082 0.714285714285714 18.5 18 5 abnormal vitelline vein topology 0.0127559357640173 0.0740499188167866 1.14480808435082 0.714285714285714 18.5 18 5 cellular necrosis 0.0817510845330393 0.262897574327077 1.14480808435082 0.714285714285714 18.5 18 5 maxilla hypoplasia 0.0817510845330393 0.262897574327077 1.14480808435082 0.714285714285714 18.5 18 5 mammary gland hyperplasia 0.0817510845330393 0.262897574327077 1.14480808435082 0.714285714285714 18.5 18 5 abnormal oculomotor nerve morphology 0.0817510845330393 0.262897574327077 1.14480808435082 0.714285714285714 18.5 18 5 abnormal circulating alanine transaminase level 0.0817510845330393 0.262897574327077 1.14480808435082 0.714285714285714 18.5 18 5 abnormal axial mesoderm 0.0817510845330393 0.262897574327077 1.14480808435082 0.714285714285714 18.5 18 5 decreased activated T cell number 0.0817510845330393 0.262897574327077 1.14480808435082 0.714285714285714 18.5 18 5 increased colonic adenoma incidence 0.0817510845330393 0.262897574327077 1.14480808435082 0.714285714285714 18.5 18 5 decreased mortality induced by ionizing radiation 0.0817510845330393 0.262897574327077 1.14480808435082 0.714285714285714 18.5 18 5 abnormal hard palate morphology 0.0817510845330393 0.262897574327077 1.14480808435082 0.714285714285714 18.5 18 5 abnormal optic tract morphology 0.0817510845330393 0.262897574327077 1.14480808435082 0.714285714285714 18.5 18 5 abnormal organ of Corti supporting cell morphology 0.0817510845330393 0.262897574327077 1.14480808435082 0.714285714285714 18.5 18 5 increased prostate gland weight 0.0817510845330393 0.262897574327077 1.14480808435082 0.714285714285714 18.5 18 5 abnormal thyroid hormone level 0.0817510845330393 0.262897574327077 1.14480808435082 0.714285714285714 18.5 18 5 abnormal renal/urinary system physiology 0.0817510845330393 0.262897574327077 1.14480808435082 0.714285714285714 18.5 18 5 abnormal renal filtration rate 0.0817510845330393 0.262897574327077 1.14480808435082 0.714285714285714 18.5 18 5 decreased tidal volume 0.0817510845330393 0.262897574327077 1.14480808435082 0.714285714285714 18.5 18 5 absent popliteal lymph nodes 0.0817510845330393 0.262897574327077 1.14480808435082 0.714285714285714 18.5 18 5 uremia 0.0817510845330393 0.262897574327077 1.14480808435082 0.714285714285714 18.5 18 5 arteritis 0.0817510845330393 0.262897574327077 1.14480808435082 0.714285714285714 18.5 18 5 focal dorsal hair loss 0.0817510845330393 0.262897574327077 1.14480808435082 0.714285714285714 18.5 18 5 abnormal retina inner limiting membrane morphology 0.0817510845330393 0.262897574327077 1.14480808435082 0.714285714285714 18.5 18 5 long stride length 0.0817510845330393 0.262897574327077 1.14480808435082 0.714285714285714 18.5 18 5 heart block 0.0817510845330393 0.262897574327077 1.14480808435082 0.714285714285714 18.5 18 5 abnormal aortic valve cusp morphology 0.0817510845330393 0.262897574327077 1.14480808435082 0.714285714285714 18.5 18 5 altered tumor pathology 0.0817510845330393 0.262897574327077 1.14480808435082 0.714285714285714 18.5 18 5 increased right ventricle systolic pressure 0.0817510845330393 0.262897574327077 1.14480808435082 0.714285714285714 18.5 18 5 small lung saccule 0.0817510845330393 0.262897574327077 1.14480808435082 0.714285714285714 18.5 18 5 abnormal tricarboxylic acid cycle 0.0817510845330393 0.262897574327077 1.14480808435082 0.714285714285714 18.5 18 5 increased compact bone volume 0.0817510845330393 0.262897574327077 1.14480808435082 0.714285714285714 18.5 18 5 small lung lobe 0.0817510845330393 0.262897574327077 1.14480808435082 0.714285714285714 18.5 18 5 abnormal outer hair cell kinocilium morphology 0.0817510845330393 0.262897574327077 1.14480808435082 0.714285714285714 18.5 18 5 embryonic lethality at implantation, incomplete penetrance 0.0817510845330393 0.262897574327077 1.14480808435082 0.714285714285714 18.5 18 5 small tail bud 0.0817510845330393 0.262897574327077 1.14480808435082 0.714285714285714 18.5 18 5 impaired mammary gland growth during pregnancy 0.0817510845330393 0.262897574327077 1.14480808435082 0.714285714285714 18.5 18 5 absent connection between subcutaneous lymph vessels and lymph sac 0.0817510845330393 0.262897574327077 1.14480808435082 0.714285714285714 18.5 18 5 embryo tumor 0.0817510845330393 0.262897574327077 1.14480808435082 0.714285714285714 18.5 18 5 preweaning lethality, complete penetrance 3.17266353232204e-75 1.57840010733021e-71 1.14357045398936 0.713513513513514 18.5 18 5 ventricular septal defect 6.76250416697473e-15 7.47632405126651e-13 1.1431245430503 0.713235294117647 18.5 18 5 decreased percent body fat/body weight 1.30669628524749e-08 4.8513537456017e-07 1.14167162384575 0.712328767123288 18.5 18 5 embryonic growth arrest 7.07060621551609e-24 2.19851662013703e-21 1.1408087547985 0.7117903930131 18.5 18 5 abnormal myocardial trabeculae morphology 8.80358752956823e-06 0.000164036883743827 1.13972004842037 0.711111111111111 18.5 18 5 small placenta 8.80358752956823e-06 0.000164036883743827 1.13972004842037 0.711111111111111 18.5 18 5 cataract 3.12183921434712e-13 2.54609017891425e-11 1.13913135004825 0.710743801652893 18.5 18 5 decreased hair follicle number 4.5772804990605e-05 0.000687974939058187 1.13878277864371 0.710526315789474 18.5 18 5 decreased neuron apoptosis 4.5772804990605e-05 0.000687974939058187 1.13878277864371 0.710526315789474 18.5 18 5 abnormal eyelid morphology 0.000241521224297447 0.00299642915431371 1.1374222257421 0.709677419354839 18.5 18 5 abnormal capillary morphology 0.000241521224297447 0.00299642915431371 1.1374222257421 0.709677419354839 18.5 18 5 abnormal digit morphology 2.44151529000351e-08 8.61456636011879e-07 1.13526801698123 0.708333333333333 18.5 18 5 abnormal body weight 0.00130295987600961 0.012093704073037 1.13526801698123 0.708333333333333 18.5 18 5 abnormal lung saccule morphology 0.00130295987600961 0.012093704073037 1.13526801698123 0.708333333333333 18.5 18 5 palatal shelves fail to meet at midline 2.74455596229007e-05 0.000440456964915907 1.1336392249913 0.707317073170732 18.5 18 5 abnormal embryonic neuroepithelium morphology 6.26324511200325e-07 1.56581127800081e-05 1.13296524209891 0.706896551724138 18.5 18 5 hemorrhage 1.0496077823744e-23 2.9009992873959e-21 1.13214212256651 0.706382978723404 18.5 18 5 increased lung adenocarcinoma incidence 3.19874063877833e-06 6.91901507735748e-05 1.13133975394669 0.705882352941177 18.5 18 5 abnormal interatrial septum morphology 0.00729280476223349 0.0481189704139411 1.13133975394669 0.705882352941177 18.5 18 5 hydroureter 0.00729280476223349 0.0481189704139411 1.13133975394669 0.705882352941177 18.5 18 5 hyperlipidemia 0.00729280476223349 0.0481189704139411 1.13133975394669 0.705882352941177 18.5 18 5 abnormal testis development 0.00729280476223349 0.0481189704139411 1.13133975394669 0.705882352941177 18.5 18 5 abnormal ectoplacental cone morphology 0.00729280476223349 0.0481189704139411 1.13133975394669 0.705882352941177 18.5 18 5 abnormal melanosome morphology 0.00729280476223349 0.0481189704139411 1.13133975394669 0.705882352941177 18.5 18 5 pancytopenia 0.00729280476223349 0.0481189704139411 1.13133975394669 0.705882352941177 18.5 18 5 enhanced behavioral response to cocaine 0.00729280476223349 0.0481189704139411 1.13133975394669 0.705882352941177 18.5 18 5 increased embryonic tissue cell apoptosis 9.01608602629146e-09 3.504299061e-07 1.13013105762837 0.705128205128205 18.5 18 5 omphalocele 1.64649935074179e-05 0.000281489150169774 1.12919706501876 0.704545454545455 18.5 18 5 decreased blood urea nitrogen level 1.64649935074179e-05 0.000281489150169774 1.12919706501876 0.704545454545455 18.5 18 5 embryonic lethality before implantation, complete penetrance 4.02064441812547e-13 3.17503269526575e-11 1.12832284793617 0.704 18.5 18 5 abnormal neural tube morphology 1.51787226980924e-16 1.93626013905153e-14 1.12784796458266 0.703703703703704 18.5 18 5 neurodegeneration 1.92847655552083e-06 4.48325741295147e-05 1.12784796458266 0.703703703703704 18.5 18 5 abnormal trigeminal ganglion morphology 0.000766554007126691 0.0078793516228415 1.12784796458266 0.703703703703704 18.5 18 5 decreased circulating fructosamine level 0.000766554007126691 0.0078793516228415 1.12784796458266 0.703703703703704 18.5 18 5 edema 1.87373429141727e-17 2.82479639387907e-15 1.12750284586645 0.703488372093023 18.5 18 5 increased grip strength 6.64950844536299e-10 3.12087778449819e-08 1.12719565228388 0.703296703296703 18.5 18 5 malocclusion 8.56542244727068e-05 0.00118041486634824 1.12624362892891 0.702702702702703 18.5 18 5 increased erythroid progenitor cell number 8.56542244727068e-05 0.00118041486634824 1.12624362892891 0.702702702702703 18.5 18 5 abnormal respiratory electron transport chain 8.56542244727068e-05 0.00118041486634824 1.12624362892891 0.702702702702703 18.5 18 5 increased respiratory quotient 9.88292893250868e-06 0.000182102116441595 1.12532198929804 0.702127659574468 18.5 18 5 decreased hemoglobin content 1.8416083744084e-14 1.86979625769016e-12 1.12532198929804 0.702127659574468 18.5 18 5 increased erythrocyte cell number 7.01338727808705e-07 1.74458008542415e-05 1.1219119226638 0.7 18.5 18 5 disorganized myocardium 0.000452320457176132 0.00512595506708715 1.1219119226638 0.7 18.5 18 5 abnormal optic cup morphology 0.000452320457176132 0.00512595506708715 1.1219119226638 0.7 18.5 18 5 anencephaly 0.00420671978442674 0.0314713247030421 1.1219119226638 0.7 18.5 18 5 abnormal sperm mitochondrial sheath morphology 0.00420671978442674 0.0314713247030421 1.1219119226638 0.7 18.5 18 5 absent ductus venosus valve 0.00420671978442674 0.0314713247030421 1.1219119226638 0.7 18.5 18 5 abnormal auchene hair morphology 0.043904243532995 0.178663369062033 1.1219119226638 0.7 18.5 18 5 increased cranium width 0.043904243532995 0.178663369062033 1.1219119226638 0.7 18.5 18 5 jaundice 0.043904243532995 0.178663369062033 1.1219119226638 0.7 18.5 18 5 abnormal immune cell physiology 0.043904243532995 0.178663369062033 1.1219119226638 0.7 18.5 18 5 impaired social transmission of food preference 0.043904243532995 0.178663369062033 1.1219119226638 0.7 18.5 18 5 acrania 0.043904243532995 0.178663369062033 1.1219119226638 0.7 18.5 18 5 aneurysm 0.043904243532995 0.178663369062033 1.1219119226638 0.7 18.5 18 5 peritoneal inflammation 0.043904243532995 0.178663369062033 1.1219119226638 0.7 18.5 18 5 absent seminal vesicle 0.043904243532995 0.178663369062033 1.1219119226638 0.7 18.5 18 5 absent pharyngeal arches 0.043904243532995 0.178663369062033 1.1219119226638 0.7 18.5 18 5 abnormal gas homeostasis 0.043904243532995 0.178663369062033 1.1219119226638 0.7 18.5 18 5 abnormal plasma membrane morphology 0.043904243532995 0.178663369062033 1.1219119226638 0.7 18.5 18 5 abnormal placental transport 0.043904243532995 0.178663369062033 1.1219119226638 0.7 18.5 18 5 abnormal deltoid tuberosity morphology 0.043904243532995 0.178663369062033 1.1219119226638 0.7 18.5 18 5 increased susceptibility to atherosclerosis 0.043904243532995 0.178663369062033 1.1219119226638 0.7 18.5 18 5 osteosclerosis 0.043904243532995 0.178663369062033 1.1219119226638 0.7 18.5 18 5 increased platelet aggregation 0.043904243532995 0.178663369062033 1.1219119226638 0.7 18.5 18 5 abnormal hippocampus neuron morphology 0.043904243532995 0.178663369062033 1.1219119226638 0.7 18.5 18 5 acanthocytosis 0.043904243532995 0.178663369062033 1.1219119226638 0.7 18.5 18 5 abnormal heart and great artery attachment 0.043904243532995 0.178663369062033 1.1219119226638 0.7 18.5 18 5 abnormal left subclavian artery morphology 0.043904243532995 0.178663369062033 1.1219119226638 0.7 18.5 18 5 thin ventricle myocardium compact layer 0.043904243532995 0.178663369062033 1.1219119226638 0.7 18.5 18 5 thick aortic valve 0.043904243532995 0.178663369062033 1.1219119226638 0.7 18.5 18 5 decreased macrophage cytokine production 0.043904243532995 0.178663369062033 1.1219119226638 0.7 18.5 18 5 microphthalmia 2.54496939463377e-15 2.99665600601074e-13 1.12086438585459 0.699346405228758 18.5 18 5 increased circulating aspartate transaminase level 4.23080887398493e-07 1.11366529883995e-05 1.11936790469858 0.698412698412698 18.5 18 5 abnormal coat/ hair morphology 3.5664431789855e-06 7.4550650485096e-05 1.11888790130891 0.69811320754717 18.5 18 5 abnormal placenta development 3.5664431789855e-06 7.4550650485096e-05 1.11888790130891 0.69811320754717 18.5 18 5 increased circulating bilirubin level 3.5664431789855e-06 7.4550650485096e-05 1.11888790130891 0.69811320754717 18.5 18 5 atrioventricular septal defect 3.5664431789855e-06 7.4550650485096e-05 1.11888790130891 0.69811320754717 18.5 18 5 prenatal lethality, complete penetrance 2.1620045901751e-26 7.68283774008652e-24 1.1184527903226 0.697841726618705 18.5 18 5 abnormal QRS complex 0.000267587451619192 0.00330334385063395 1.11705516109383 0.696969696969697 18.5 18 5 decreased spleen weight 1.54066762254675e-07 4.58971342644916e-06 1.11494352562862 0.695652173913043 18.5 18 5 atrial septal defect 1.82552005954983e-05 0.000303744558403358 1.11494352562862 0.695652173913043 18.5 18 5 abnormal cranial nerve morphology 0.00244315179985323 0.0206011528885929 1.11494352562862 0.695652173913043 18.5 18 5 hydrops fetalis 9.30034342952855e-08 2.89182553511903e-06 1.11300785978552 0.694444444444444 18.5 18 5 abnormal bone structure 2.20258825213447e-18 3.7785781221962e-16 1.11277718458142 0.694300518134715 18.5 18 5 increased T cell derived lymphoma incidence 1.09268375347214e-05 0.00019696020556246 1.1120992819408 0.693877551020408 18.5 18 5 small kidney 4.11285388083836e-09 1.7051206714309e-07 1.11098420913136 0.693181818181818 18.5 18 5 distended pericardium 6.54621074500393e-06 0.000126991881823508 1.10958322021695 0.692307692307692 18.5 18 5 abnormal snout morphology 6.54621074500393e-06 0.000126991881823508 1.10958322021695 0.692307692307692 18.5 18 5 decreased kidney weight 6.54621074500393e-06 0.000126991881823508 1.10958322021695 0.692307692307692 18.5 18 5 decreased bone resorption 0.001426574998857 0.0131918412998394 1.10958322021695 0.692307692307692 18.5 18 5 absent teeth 0.0242999370668472 0.117257213295407 1.10958322021695 0.692307692307692 18.5 18 5 abnormal tail bud morphology 0.0242999370668472 0.117257213295407 1.10958322021695 0.692307692307692 18.5 18 5 empty decidua capsularis 0.0242999370668472 0.117257213295407 1.10958322021695 0.692307692307692 18.5 18 5 abnormal embryo development 3.76808164065437e-13 3.02358163907347e-11 1.10777017573947 0.691176470588235 18.5 18 5 decreased circulating total protein level 3.92501560461715e-06 8.13623026373764e-05 1.10734163795388 0.690909090909091 18.5 18 5 disheveled coat 5.6089466390901e-05 0.000825577205014001 1.10664781487246 0.69047619047619 18.5 18 5 abnormal brain morphology 3.84179163733452e-15 4.3438439535771e-13 1.10498867272123 0.68944099378882 18.5 18 5 trabecula carnea hypoplasia 3.34295353155134e-05 0.00052299351633547 1.10410379690723 0.688888888888889 18.5 18 5 abnormal definitive hematopoiesis 2.73237856324176e-09 1.16184473095109e-07 1.1029548855681 0.688172043010753 18.5 18 5 decreased bone mineral content 6.6192927573134e-19 1.31723925870537e-16 1.10187778118766 0.6875 18.5 18 5 oligodactyly 1.99512053041334e-05 0.000329758293648051 1.10187778118766 0.6875 18.5 18 5 curly tail 1.99512053041334e-05 0.000329758293648051 1.10187778118766 0.6875 18.5 18 5 abnormal vertebral body morphology 0.000492419766595148 0.00541988570533376 1.10187778118766 0.6875 18.5 18 5 neonatal lethality 0.000492419766595148 0.00541988570533376 1.10187778118766 0.6875 18.5 18 5 abnormal embryonic hematopoiesis 0.000492419766595148 0.00541988570533376 1.10187778118766 0.6875 18.5 18 5 abnormal tympanic ring morphology 0.0137011309209597 0.0781687228575396 1.10187778118766 0.6875 18.5 18 5 vasculature congestion 0.0137011309209597 0.0781687228575396 1.10187778118766 0.6875 18.5 18 5 abnormal epicardium morphology 0.0137011309209597 0.0781687228575396 1.10187778118766 0.6875 18.5 18 5 increased pancreatic beta cell number 0.0137011309209597 0.0781687228575396 1.10187778118766 0.6875 18.5 18 5 decreased liver cholesterol level 0.0137011309209597 0.0781687228575396 1.10187778118766 0.6875 18.5 18 5 decreased midbrain size 0.0137011309209597 0.0781687228575396 1.10187778118766 0.6875 18.5 18 5 decreased fibroblast apoptosis 0.0137011309209597 0.0781687228575396 1.10187778118766 0.6875 18.5 18 5 anemia 4.01869831238475e-19 8.6926191757018e-17 1.10140303849866 0.687203791469194 18.5 18 5 embryonic lethality during organogenesis, incomplete penetrance 1.11492926969823e-20 2.919354271973e-18 1.10100673155827 0.68695652173913 18.5 18 5 hydroencephaly 4.49294314861462e-11 2.62969319580679e-09 1.10100673155827 0.68695652173913 18.5 18 5 abnormal extraembryonic tissue morphology 6.04136134750544e-10 2.86245454322281e-08 1.09991364967039 0.686274509803922 18.5 18 5 failure of chorioallantoic fusion 1.19216312386846e-05 0.000210319558200198 1.09991364967039 0.686274509803922 18.5 18 5 abnormal axon morphology 2.21057681168908e-10 1.11087067052052e-08 1.09816775498838 0.685185185185185 18.5 18 5 increased cell proliferation 7.13142935946734e-06 0.000135934333576054 1.09816775498838 0.685185185185185 18.5 18 5 abnormal fertility/fecundity 1.8491889855121e-07 5.37995041106589e-06 1.09776117677476 0.684931506849315 18.5 18 5 abnormal circulating amino acid level 4.27017398458659e-06 8.77856015426376e-05 1.09660563869394 0.684210526315789 18.5 18 5 abnormal sternebra morphology 0.00782345345792304 0.0510121811296059 1.09660563869394 0.684210526315789 18.5 18 5 abnormal eye morphology 8.14373953351872e-13 6.13865214837206e-11 1.09539190804791 0.683453237410072 18.5 18 5 decreased total body fat amount 1.40701415259312e-28 5.38453493011596e-26 1.09408006145144 0.682634730538922 18.5 18 5 abnormal germ layer development 0.00450855568301915 0.0327924919927197 1.09277135324396 0.681818181818182 18.5 18 5 increased skin papilloma incidence 0.00450855568301915 0.0327924919927197 1.09277135324396 0.681818181818182 18.5 18 5 increased myocardial infarction size 0.00450855568301915 0.0327924919927197 1.09277135324396 0.681818181818182 18.5 18 5 prolonged PR interval 0.00450855568301915 0.0327924919927197 1.09277135324396 0.681818181818182 18.5 18 5 increased mammary gland tumor incidence 0.00450855568301915 0.0327924919927197 1.09277135324396 0.681818181818182 18.5 18 5 abnormal sternum morphology 5.53433723437935e-07 1.39933942260666e-05 1.09171553551136 0.681159420289855 18.5 18 5 increased cellular sensitivity to ionizing radiation 0.00261650133305352 0.021914299885423 1.08985729630198 0.68 18.5 18 5 decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 0.00261650133305352 0.021914299885423 1.08985729630198 0.68 18.5 18 5 increased circulating alanine transaminase level 1.20355471651216e-07 3.65102726502928e-06 1.08903538280552 0.67948717948718 18.5 18 5 extramedullary hematopoiesis 7.10751871323613e-10 3.30466407461213e-08 1.08864768776002 0.679245283018868 18.5 18 5 abnormal eye development 7.68469222868233e-06 0.000145754664810491 1.08756768013328 0.678571428571429 18.5 18 5 rib bifurcation 0.00152687202008021 0.0140151075643893 1.08756768013328 0.678571428571429 18.5 18 5 small superior cervical ganglion 0.00152687202008021 0.0140151075643893 1.08756768013328 0.678571428571429 18.5 18 5 abnormal mitotic spindle morphology 0.00152687202008021 0.0140151075643893 1.08756768013328 0.678571428571429 18.5 18 5 prenatal lethality 2.75414549600956e-06 6.08972170784337e-05 1.0857212154811 0.67741935483871 18.5 18 5 abnormal object recognition memory 0.000894998846221372 0.00901339931164236 1.0857212154811 0.67741935483871 18.5 18 5 decreased circulating serum albumin level 3.47619407204355e-09 1.45328281583333e-07 1.08467675062734 0.676767676767677 18.5 18 5 enlarged liver sinusoidal spaces 0.000526551608693385 0.00565787095734253 1.08420059753225 0.676470588235294 18.5 18 5 overexpanded pulmonary alveoli 0.000526551608693385 0.00565787095734253 1.08420059753225 0.676470588235294 18.5 18 5 abnormal nervous system development 0.000526551608693385 0.00565787095734253 1.08420059753225 0.676470588235294 18.5 18 5 abnormal branching of the mammary ductal tree 0.000310742004802603 0.00376141477832835 1.0829265662778 0.675675675675676 18.5 18 5 increased circulating phosphate level 0.000310742004802603 0.00376141477832835 1.0829265662778 0.675675675675676 18.5 18 5 preweaning lethality, incomplete penetrance 5.73750707201342e-33 2.59491797120607e-30 1.08154974032557 0.67481662591687 18.5 18 5 increased oxygen consumption 4.67964868652113e-08 1.54642118962964e-06 1.08091181917775 0.674418604651163 18.5 18 5 abnormal double-strand DNA break repair 0.000109037832035982 0.00149028355598629 1.08091181917775 0.674418604651163 18.5 18 5 decreased rib number 2.81858712587328e-08 9.75141147046879e-07 1.08049302343223 0.674157303370786 18.5 18 5 abnormal cell death 6.47898270702107e-05 0.000931587831428608 1.08010154045273 0.673913043478261 18.5 18 5 abnormal myelin sheath morphology 6.47898270702107e-05 0.000931587831428608 1.08010154045273 0.673913043478261 18.5 18 5 abnormal embryonic tissue morphology 1.10156020180506e-12 8.05920882938259e-11 1.07939047953077 0.673469387755102 18.5 18 5 eyelids open at birth 2.29886734315565e-05 0.000377454291491729 1.07876146409981 0.673076923076923 18.5 18 5 decreased caudal vertebrae number 2.93830646052278e-06 6.3834387079043e-05 1.07683510434249 0.671875 18.5 18 5 abnormal tooth morphology 2.93830646052278e-06 6.3834387079043e-05 1.07683510434249 0.671875 18.5 18 5 increased sacral vertebrae number 2.93830646052278e-06 6.3834387079043e-05 1.07683510434249 0.671875 18.5 18 5 cleft palate 2.40507333164161e-11 1.51458731960975e-09 1.07664393887039 0.67175572519084 18.5 18 5 abnormal somite development 2.28983385806667e-07 6.32884635771205e-06 1.07525012479533 0.670886075949367 18.5 18 5 abnormal developmental patterning 1.37710498159164e-07 4.12716703820386e-06 1.07500271335382 0.670731707317073 18.5 18 5 increased mean corpuscular hemoglobin 1.1565877469402e-08 4.35910912199052e-07 1.0684875453941 0.666666666666667 18.5 18 5 abnormal forebrain development 1.11876874279734e-06 2.71506072947159e-05 1.0684875453941 0.666666666666667 18.5 18 5 renal hypoplasia 0.000554804923021833 0.00593581611190025 1.0684875453941 0.666666666666667 18.5 18 5 increased metastatic potential 0.00160524356446822 0.014580965230399 1.0684875453941 0.666666666666667 18.5 18 5 abnormal brain vasculature morphology 0.00160524356446822 0.014580965230399 1.0684875453941 0.666666666666667 18.5 18 5 thin epidermis 0.00274661698231763 0.0225485470083007 1.0684875453941 0.666666666666667 18.5 18 5 abnormal eye muscle morphology 0.00274661698231763 0.0225485470083007 1.0684875453941 0.666666666666667 18.5 18 5 abnormal skin appearance 0.00274661698231763 0.0225485470083007 1.0684875453941 0.666666666666667 18.5 18 5 abnormal megakaryocyte differentiation 0.0142665158769815 0.0795694131031198 1.0684875453941 0.666666666666667 18.5 18 5 abnormal mitral valve morphology 0.0142665158769815 0.0795694131031198 1.0684875453941 0.666666666666667 18.5 18 5 right pulmonary isomerism 0.0142665158769815 0.0795694131031198 1.0684875453941 0.666666666666667 18.5 18 5 abnormal thyroid cartilage morphology 0.0142665158769815 0.0795694131031198 1.0684875453941 0.666666666666667 18.5 18 5 abnormal metacarpal bone morphology 0.0142665158769815 0.0795694131031198 1.0684875453941 0.666666666666667 18.5 18 5 absent inner cell mass 0.0142665158769815 0.0795694131031198 1.0684875453941 0.666666666666667 18.5 18 5 darkened coat color 0.0142665158769815 0.0795694131031198 1.0684875453941 0.666666666666667 18.5 18 5 decreased lactate dehydrogenase level 0.0142665158769815 0.0795694131031198 1.0684875453941 0.666666666666667 18.5 18 5 decreased pulmonary respiratory rate 0.0142665158769815 0.0795694131031198 1.0684875453941 0.666666666666667 18.5 18 5 abnormal pregnancy 0.0142665158769815 0.0795694131031198 1.0684875453941 0.666666666666667 18.5 18 5 abnormal fontanelle morphology 0.0251714393769399 0.119135321237149 1.0684875453941 0.666666666666667 18.5 18 5 absent incisors 0.0251714393769399 0.119135321237149 1.0684875453941 0.666666666666667 18.5 18 5 interdigital webbing 0.0251714393769399 0.119135321237149 1.0684875453941 0.666666666666667 18.5 18 5 decreased hepatocyte number 0.0251714393769399 0.119135321237149 1.0684875453941 0.666666666666667 18.5 18 5 abnormal cricoid cartilage morphology 0.0251714393769399 0.119135321237149 1.0684875453941 0.666666666666667 18.5 18 5 abnormal bronchus morphology 0.0251714393769399 0.119135321237149 1.0684875453941 0.666666666666667 18.5 18 5 abnormal pericyte morphology 0.0251714393769399 0.119135321237149 1.0684875453941 0.666666666666667 18.5 18 5 abnormal placenta size 0.0251714393769399 0.119135321237149 1.0684875453941 0.666666666666667 18.5 18 5 immune system phenotype 0.0251714393769399 0.119135321237149 1.0684875453941 0.666666666666667 18.5 18 5 herniated liver 0.0251714393769399 0.119135321237149 1.0684875453941 0.666666666666667 18.5 18 5 heterochrony 0.0251714393769399 0.119135321237149 1.0684875453941 0.666666666666667 18.5 18 5 decreased brown adipose tissue mass 0.0251714393769399 0.119135321237149 1.0684875453941 0.666666666666667 18.5 18 5 renal tubular acidosis 0.0827532867128045 0.262897574327077 1.0684875453941 0.666666666666667 18.5 18 5 abnormal urinary bladder urothelium morphology 0.0827532867128045 0.262897574327077 1.0684875453941 0.666666666666667 18.5 18 5 synostosis 0.0827532867128045 0.262897574327077 1.0684875453941 0.666666666666667 18.5 18 5 abnormal cholinergic neuron morphology 0.0827532867128045 0.262897574327077 1.0684875453941 0.666666666666667 18.5 18 5 abnormal geniculate ganglion morphology 0.0827532867128045 0.262897574327077 1.0684875453941 0.666666666666667 18.5 18 5 abnormal germ cell morphology 0.0827532867128045 0.262897574327077 1.0684875453941 0.666666666666667 18.5 18 5 abnormal posterior semicircular canal morphology 0.0827532867128045 0.262897574327077 1.0684875453941 0.666666666666667 18.5 18 5 polycythemia 0.0827532867128045 0.262897574327077 1.0684875453941 0.666666666666667 18.5 18 5 decreased circulating bicarbonate level 0.0827532867128045 0.262897574327077 1.0684875453941 0.666666666666667 18.5 18 5 abnormal lens capsule morphology 0.0827532867128045 0.262897574327077 1.0684875453941 0.666666666666667 18.5 18 5 abnormal abdominal wall morphology 0.0827532867128045 0.262897574327077 1.0684875453941 0.666666666666667 18.5 18 5 biliary cyst 0.0827532867128045 0.262897574327077 1.0684875453941 0.666666666666667 18.5 18 5 abnormal artery development 0.0827532867128045 0.262897574327077 1.0684875453941 0.666666666666667 18.5 18 5 abnormal ovary physiology 0.0827532867128045 0.262897574327077 1.0684875453941 0.666666666666667 18.5 18 5 liver hyperplasia 0.0827532867128045 0.262897574327077 1.0684875453941 0.666666666666667 18.5 18 5 abnormal intervertebral disk development 0.0827532867128045 0.262897574327077 1.0684875453941 0.666666666666667 18.5 18 5 decreased susceptibility to atherosclerosis 0.0827532867128045 0.262897574327077 1.0684875453941 0.666666666666667 18.5 18 5 abnormal optic chiasm morphology 0.0827532867128045 0.262897574327077 1.0684875453941 0.666666666666667 18.5 18 5 abnormal liver vasculature morphology 0.0827532867128045 0.262897574327077 1.0684875453941 0.666666666666667 18.5 18 5 abnormal hippocampus granule cell morphology 0.0827532867128045 0.262897574327077 1.0684875453941 0.666666666666667 18.5 18 5 abnormal cerebellar layer morphology 0.0827532867128045 0.262897574327077 1.0684875453941 0.666666666666667 18.5 18 5 abnormal telomere morphology 0.0827532867128045 0.262897574327077 1.0684875453941 0.666666666666667 18.5 18 5 prolonged RR interval 0.0827532867128045 0.262897574327077 1.0684875453941 0.666666666666667 18.5 18 5 decreased effector memory CD4-positive, alpha-beta T cell number 0.0827532867128045 0.262897574327077 1.0684875453941 0.666666666666667 18.5 18 5 abnormal pulmonary alveolar system morphology 0.0827532867128045 0.262897574327077 1.0684875453941 0.666666666666667 18.5 18 5 increased core body temperature 0.0827532867128045 0.262897574327077 1.0684875453941 0.666666666666667 18.5 18 5 decreased pancreatic beta cell proliferation 0.0827532867128045 0.262897574327077 1.0684875453941 0.666666666666667 18.5 18 5 trigeminal neuroma 0.0827532867128045 0.262897574327077 1.0684875453941 0.666666666666667 18.5 18 5 decreased birth body size 9.24654693516565e-10 4.22032761490359e-08 1.0684875453941 0.666666666666667 18.5 18 5 abnormal retinal pigmentation 8.78128117191183e-08 2.78260342867907e-06 1.0684875453941 0.666666666666667 18.5 18 5 gliosis 5.19241506370576e-06 0.000105869938286624 1.0684875453941 0.666666666666667 18.5 18 5 impaired hematopoiesis 4.0758086638619e-05 0.000621998408058679 1.0684875453941 0.666666666666667 18.5 18 5 thymus atrophy 6.84457298213614e-05 0.000975694859201355 1.0684875453941 0.666666666666667 18.5 18 5 single kidney 0.000942084396547063 0.00944933442101136 1.0684875453941 0.666666666666667 18.5 18 5 abnormal adrenal gland morphology 0.00472353564754045 0.0339099420584614 1.0684875453941 0.666666666666667 18.5 18 5 curly vibrissae 0.00472353564754045 0.0339099420584614 1.0684875453941 0.666666666666667 18.5 18 5 blindness 0.00472353564754045 0.0339099420584614 1.0684875453941 0.666666666666667 18.5 18 5 abnormal inner cell mass apoptosis 0.00472353564754045 0.0339099420584614 1.0684875453941 0.666666666666667 18.5 18 5 increased incidence of induced tumors 0.00817536142490704 0.0516265641374548 1.0684875453941 0.666666666666667 18.5 18 5 abnormal embryonic/fetal subventricular zone morphology 0.00817536142490704 0.0516265641374548 1.0684875453941 0.666666666666667 18.5 18 5 vascular ring 0.00817536142490704 0.0516265641374548 1.0684875453941 0.666666666666667 18.5 18 5 abnormal mineral level 0.0451057671441032 0.178663369062033 1.0684875453941 0.666666666666667 18.5 18 5 decreased digestive secretion 0.0451057671441032 0.178663369062033 1.0684875453941 0.666666666666667 18.5 18 5 abnormal thymus involution 0.0451057671441032 0.178663369062033 1.0684875453941 0.666666666666667 18.5 18 5 interstitial pneumonia 0.0451057671441032 0.178663369062033 1.0684875453941 0.666666666666667 18.5 18 5 altered tumor susceptibility 0.0451057671441032 0.178663369062033 1.0684875453941 0.666666666666667 18.5 18 5 abnormal respiratory function 0.0451057671441032 0.178663369062033 1.0684875453941 0.666666666666667 18.5 18 5 small thyroid gland 0.0451057671441032 0.178663369062033 1.0684875453941 0.666666666666667 18.5 18 5 abnormal gastrocnemius morphology 0.0451057671441032 0.178663369062033 1.0684875453941 0.666666666666667 18.5 18 5 abnormal aorta elastic fiber morphology 0.0451057671441032 0.178663369062033 1.0684875453941 0.666666666666667 18.5 18 5 loss of dopaminergic neurons 0.0451057671441032 0.178663369062033 1.0684875453941 0.666666666666667 18.5 18 5 dilated bile duct 0.0451057671441032 0.178663369062033 1.0684875453941 0.666666666666667 18.5 18 5 absent ovary 0.0451057671441032 0.178663369062033 1.0684875453941 0.666666666666667 18.5 18 5 abnormal defecation 0.0451057671441032 0.178663369062033 1.0684875453941 0.666666666666667 18.5 18 5 increased hepatocyte proliferation 0.0451057671441032 0.178663369062033 1.0684875453941 0.666666666666667 18.5 18 5 abnormal palatine bone morphology 0.0451057671441032 0.178663369062033 1.0684875453941 0.666666666666667 18.5 18 5 decreased renal glomerular filtration rate 0.0451057671441032 0.178663369062033 1.0684875453941 0.666666666666667 18.5 18 5 hydrometra 0.0451057671441032 0.178663369062033 1.0684875453941 0.666666666666667 18.5 18 5 increased skeletal muscle glycogen level 0.0451057671441032 0.178663369062033 1.0684875453941 0.666666666666667 18.5 18 5 abnormal colon goblet cell morphology 0.0451057671441032 0.178663369062033 1.0684875453941 0.666666666666667 18.5 18 5 decreased cell proliferation 9.26783759607807e-15 9.81010468946562e-13 1.06559974121736 0.664864864864865 18.5 18 5 abnormal heart development 8.50516539997294e-13 6.31540266639782e-11 1.06510625569348 0.664556962025316 18.5 18 5 anophthalmia 9.25512764976634e-08 2.89182553511903e-06 1.06248480637503 0.662921348314607 18.5 18 5 short tail 2.55531323220242e-07 7.02358195039062e-06 1.06205087343389 0.662650602409639 18.5 18 5 decreased oocyte number 7.16225500677314e-05 0.00101806339024847 1.05780266994016 0.66 18.5 18 5 thymus hypoplasia 5.2521611988241e-11 3.00339103036206e-09 1.05687355033547 0.659420289855073 18.5 18 5 abnormal astrocyte morphology 0.000202561347658086 0.00262432995989318 1.05634564146916 0.659090909090909 18.5 18 5 muscular atrophy 0.000202561347658086 0.00262432995989318 1.05634564146916 0.659090909090909 18.5 18 5 renal interstitial fibrosis 0.000202561347658086 0.00262432995989318 1.05634564146916 0.659090909090909 18.5 18 5 abnormal amino acid level 0.000202561347658086 0.00262432995989318 1.05634564146916 0.659090909090909 18.5 18 5 abnormal mammary gland development 0.000341615469619059 0.00410516174240294 1.05545720947466 0.658536585365854 18.5 18 5 thick ventricular wall 0.000341615469619059 0.00410516174240294 1.05545720947466 0.658536585365854 18.5 18 5 abnormal nervous system morphology 7.39794969007935e-07 1.82201978753192e-05 1.05496238659164 0.658227848101266 18.5 18 5 abnormal heart morphology 2.89848762279099e-17 4.24116938923094e-15 1.0546110837656 0.658008658008658 18.5 18 5 abnormal axial skeleton morphology 1.23085782157488e-06 2.9439988761226e-05 1.05442849874417 0.657894736842105 18.5 18 5 seminiferous tubule degeneration 2.04914050097368e-06 4.74161581039258e-05 1.05385072970377 0.657534246575342 18.5 18 5 short snout 8.0896432047538e-09 3.19412499552779e-07 1.05364744059696 0.657407407407407 18.5 18 5 increased insulin sensitivity 3.32493278023619e-11 2.01726104654573e-09 1.05354366364033 0.657342657342657 18.5 18 5 abnormal artery morphology 0.00097859013925493 0.0096682450642656 1.05322343760275 0.657142857142857 18.5 18 5 abnormal midbrain development 0.00097859013925493 0.0096682450642656 1.05322343760275 0.657142857142857 18.5 18 5 abnormal embryonic epiblast morphology 0.00097859013925493 0.0096682450642656 1.05322343760275 0.657142857142857 18.5 18 5 increased red blood cell distribution width 0.00097859013925493 0.0096682450642656 1.05322343760275 0.657142857142857 18.5 18 5 impaired adaptive thermogenesis 0.00097859013925493 0.0096682450642656 1.05322343760275 0.657142857142857 18.5 18 5 decreased circulating HDL cholesterol level 4.10707355891602e-10 1.98375640345701e-08 1.05179242749731 0.65625 18.5 18 5 abnormal depression-related behavior 0.00166355890732597 0.0149389992129001 1.05179242749731 0.65625 18.5 18 5 abnormal microglial cell morphology 0.00283833535497963 0.0229792943333823 1.05006534633558 0.655172413793103 18.5 18 5 short sternum 0.00283833535497963 0.0229792943333823 1.05006534633558 0.655172413793103 18.5 18 5 abnormal joint morphology 4.43593322231774e-05 0.000672828286007035 1.0490604991142 0.654545454545455 18.5 18 5 abnormal platelet physiology 4.43593322231774e-05 0.000672828286007035 1.0490604991142 0.654545454545455 18.5 18 5 abnormal testis morphology 5.29061533035787e-09 2.15744354660085e-07 1.04525955527683 0.652173913043478 18.5 18 5 abnormal sacral vertebrae morphology 0.00838118796395523 0.0516265641374548 1.04525955527683 0.652173913043478 18.5 18 5 dilated heart 0.00838118796395523 0.0516265641374548 1.04525955527683 0.652173913043478 18.5 18 5 abnormal organ of Corti morphology 0.000352669250826737 0.00422702470037578 1.04363899782679 0.651162790697674 18.5 18 5 abnormal cell proliferation 0.0145402445658448 0.0796014808982718 1.04177535675925 0.65 18.5 18 5 small gonad 0.0145402445658448 0.0796014808982718 1.04177535675925 0.65 18.5 18 5 abnormal hyoid bone morphology 0.0145402445658448 0.0796014808982718 1.04177535675925 0.65 18.5 18 5 abnormal lens epithelium morphology 0.0145402445658448 0.0796014808982718 1.04177535675925 0.65 18.5 18 5 absent placental labyrinth 0.0145402445658448 0.0796014808982718 1.04177535675925 0.65 18.5 18 5 abnormal optic stalk morphology 0.0145402445658448 0.0796014808982718 1.04177535675925 0.65 18.5 18 5 abnormal postnatal subventricular zone morphology 0.0145402445658448 0.0796014808982718 1.04177535675925 0.65 18.5 18 5 kidney atrophy 0.0145402445658448 0.0796014808982718 1.04177535675925 0.65 18.5 18 5 absent vitelline blood vessels 4.57676441245358e-05 0.000687974939058187 1.04036945209425 0.649122807017544 18.5 18 5 abnormal vocalization 0.00100538261819579 0.00980740887357659 1.03960950362669 0.648648648648649 18.5 18 5 small spleen 2.99031776537386e-07 8.08523417539943e-06 1.0391334919492 0.648351648351648 18.5 18 5 abnormal liver morphology 7.56767069876467e-13 5.79217872713142e-11 1.03864152457303 0.64804469273743 18.5 18 5 increased circulating free fatty acid level 6.08704072448723e-06 0.000120649512367825 1.03838930467877 0.647887323943662 18.5 18 5 abnormal skeletal muscle fiber morphology 6.08704072448723e-06 0.000120649512367825 1.03838930467877 0.647887323943662 18.5 18 5 decreased liver weight 6.08704072448723e-06 0.000120649512367825 1.03838930467877 0.647887323943662 18.5 18 5 increased kidney weight 0.00012820739968777 0.0017379613445413 1.0370614411178 0.647058823529412 18.5 18 5 abnormal brown adipose tissue morphology 0.00170389450761214 0.0152551815683482 1.0370614411178 0.647058823529412 18.5 18 5 abnormal vagus nerve morphology 0.0254497288786245 0.11922071673367 1.0370614411178 0.647058823529412 18.5 18 5 increased incidence of corneal inflammation 0.0254497288786245 0.11922071673367 1.0370614411178 0.647058823529412 18.5 18 5 abnormal cranial suture morphology 0.0254497288786245 0.11922071673367 1.0370614411178 0.647058823529412 18.5 18 5 increased trabecular bone mass 0.0254497288786245 0.11922071673367 1.0370614411178 0.647058823529412 18.5 18 5 abnormal cell cytoskeleton morphology 0.0254497288786245 0.11922071673367 1.0370614411178 0.647058823529412 18.5 18 5 decreased body length 1.31782899372498e-18 2.34149972992207e-16 1.03534103394939 0.645985401459854 18.5 18 5 abnormal postnatal growth/weight/body size 0.00289659759764432 0.0231681238718336 1.03402020522009 0.645161290322581 18.5 18 5 decreased thymus weight 0.00289659759764432 0.0231681238718336 1.03402020522009 0.645161290322581 18.5 18 5 small cranium 0.00289659759764432 0.0231681238718336 1.03402020522009 0.645161290322581 18.5 18 5 prenatal lethality, incomplete penetrance 2.65597248897358e-20 6.29212530125883e-18 1.03333992876929 0.644736842105263 18.5 18 5 thin ventricular wall 5.09533397986911e-07 1.3134345362616e-05 1.03287129388096 0.644444444444444 18.5 18 5 abnormal somite shape 0.004942157914345 0.0348125356977401 1.03032727591574 0.642857142857143 18.5 18 5 abnormal ovulation 0.004942157914345 0.0348125356977401 1.03032727591574 0.642857142857143 18.5 18 5 absent corpus callosum 0.004942157914345 0.0348125356977401 1.03032727591574 0.642857142857143 18.5 18 5 failure of blastocyst to hatch from the zona pellucida 0.004942157914345 0.0348125356977401 1.03032727591574 0.642857142857143 18.5 18 5 hypoxia 0.004942157914345 0.0348125356977401 1.03032727591574 0.642857142857143 18.5 18 5 abnormal brainstem morphology 0.004942157914345 0.0348125356977401 1.03032727591574 0.642857142857143 18.5 18 5 abnormal renal tubule epithelium morphology 0.004942157914345 0.0348125356977401 1.03032727591574 0.642857142857143 18.5 18 5 abnormal interparietal bone morphology 0.0450791394119409 0.178663369062033 1.03032727591574 0.642857142857143 18.5 18 5 abnormal fluid regulation 0.0450791394119409 0.178663369062033 1.03032727591574 0.642857142857143 18.5 18 5 vascular smooth muscle hypoplasia 0.0450791394119409 0.178663369062033 1.03032727591574 0.642857142857143 18.5 18 5 abnormal sagittal suture morphology 0.0450791394119409 0.178663369062033 1.03032727591574 0.642857142857143 18.5 18 5 abnormal maternal decidual layer morphology 0.0450791394119409 0.178663369062033 1.03032727591574 0.642857142857143 18.5 18 5 increased circulating growth hormone level 0.0450791394119409 0.178663369062033 1.03032727591574 0.642857142857143 18.5 18 5 abnormal viscerocranium morphology 0.0450791394119409 0.178663369062033 1.03032727591574 0.642857142857143 18.5 18 5 spina bifida occulta 0.0450791394119409 0.178663369062033 1.03032727591574 0.642857142857143 18.5 18 5 increased pulmonary respiratory rate 0.0450791394119409 0.178663369062033 1.03032727591574 0.642857142857143 18.5 18 5 abnormal vertebrae morphology 4.32410462269533e-08 1.45354192553441e-06 1.02927699326954 0.642201834862385 18.5 18 5 decreased heart weight 2.31895421054587e-06 5.26794392578341e-05 1.02891393260172 0.641975308641975 18.5 18 5 internal hemorrhage 1.72643185607301e-05 0.000293139879998746 1.02861860713312 0.641791044776119 18.5 18 5 abnormal cornea morphology 3.84546762997153e-06 8.00468680297422e-05 1.02739187057125 0.641025641025641 18.5 18 5 increased monocyte cell number 1.94905347139742e-07 5.58006235968292e-06 1.02574804357833 0.64 18.5 18 5 abnormal hindlimb morphology 0.00021904257745038 0.0027799408745297 1.02574804357833 0.64 18.5 18 5 decreased circulating alkaline phosphatase level 0.00021904257745038 0.0027799408745297 1.02574804357833 0.64 18.5 18 5 ruffled hair 0.00846937442885054 0.0517630685301369 1.02574804357833 0.64 18.5 18 5 abnormal cochlear outer hair cell morphology 0.00846937442885054 0.0517630685301369 1.02574804357833 0.64 18.5 18 5 narrow eye opening 0.00172836398335964 0.0153000192477121 1.02396723100268 0.638888888888889 18.5 18 5 perinatal lethality, complete penetrance 4.69305542627134e-14 4.32369458253703e-12 1.02334018432111 0.63849765258216 18.5 18 5 abnormal tibia morphology 0.000366894885691899 0.00432536032302653 1.02301999027094 0.638297872340426 18.5 18 5 hepatic necrosis 0.000366894885691899 0.00432536032302653 1.02301999027094 0.638297872340426 18.5 18 5 neuron degeneration 0.000366894885691899 0.00432536032302653 1.02301999027094 0.638297872340426 18.5 18 5 microcephaly 1.75760115896197e-05 0.000296409009011384 1.02203156515957 0.63768115942029 18.5 18 5 perimembraneous ventricular septal defect 1.75760115896197e-05 0.000296409009011384 1.02203156515957 0.63768115942029 18.5 18 5 kinked tail 1.98629226362903e-07 5.61466137020138e-06 1.02134838897965 0.637254901960784 18.5 18 5 abnormal neuron morphology 3.27811173750899e-07 8.81546264546336e-06 1.01991992969437 0.636363636363636 18.5 18 5 abnormal basisphenoid bone morphology 0.0145922714732108 0.0796014808982718 1.01991992969437 0.636363636363636 18.5 18 5 abnormal enterocyte morphology 0.0145922714732108 0.0796014808982718 1.01991992969437 0.636363636363636 18.5 18 5 abnormal facial nerve morphology 0.0145922714732108 0.0796014808982718 1.01991992969437 0.636363636363636 18.5 18 5 abnormal tail movements 0.0145922714732108 0.0796014808982718 1.01991992969437 0.636363636363636 18.5 18 5 intracerebral hemorrhage 0.0145922714732108 0.0796014808982718 1.01991992969437 0.636363636363636 18.5 18 5 abnormal occipital bone morphology 0.0145922714732108 0.0796014808982718 1.01991992969437 0.636363636363636 18.5 18 5 abnormal awl hair morphology 0.0812137126715925 0.262897574327077 1.01991992969437 0.636363636363636 18.5 18 5 abnormal stomach epithelium morphology 0.0812137126715925 0.262897574327077 1.01991992969437 0.636363636363636 18.5 18 5 abnormal enteric ganglia morphology 0.0812137126715925 0.262897574327077 1.01991992969437 0.636363636363636 18.5 18 5 failure of somite differentiation 0.0812137126715925 0.262897574327077 1.01991992969437 0.636363636363636 18.5 18 5 vasculitis 0.0812137126715925 0.262897574327077 1.01991992969437 0.636363636363636 18.5 18 5 abnormal larynx morphology 0.0812137126715925 0.262897574327077 1.01991992969437 0.636363636363636 18.5 18 5 fatigue 0.0812137126715925 0.262897574327077 1.01991992969437 0.636363636363636 18.5 18 5 allodynia 0.0812137126715925 0.262897574327077 1.01991992969437 0.636363636363636 18.5 18 5 dilated renal glomerular capsule 0.0812137126715925 0.262897574327077 1.01991992969437 0.636363636363636 18.5 18 5 abnormal ureter development 0.0812137126715925 0.262897574327077 1.01991992969437 0.636363636363636 18.5 18 5 abnormal hair medulla 0.0812137126715925 0.262897574327077 1.01991992969437 0.636363636363636 18.5 18 5 abnormal Bruch membrane morphology 0.0812137126715925 0.262897574327077 1.01991992969437 0.636363636363636 18.5 18 5 abnormal palatal shelf elevation 0.0812137126715925 0.262897574327077 1.01991992969437 0.636363636363636 18.5 18 5 increased number of Howell-Jolly bodies 0.0812137126715925 0.262897574327077 1.01991992969437 0.636363636363636 18.5 18 5 aberrant origin of the right subclavian artery 0.0812137126715925 0.262897574327077 1.01991992969437 0.636363636363636 18.5 18 5 abnormal pulmonary alveolar sac morphology 0.0812137126715925 0.262897574327077 1.01991992969437 0.636363636363636 18.5 18 5 abnormal brain ependyma motile cilium morphology 0.0812137126715925 0.262897574327077 1.01991992969437 0.636363636363636 18.5 18 5 chylous ascites 0.0812137126715925 0.262897574327077 1.01991992969437 0.636363636363636 18.5 18 5 dextrocardia 0.00292613930118907 0.0231850238958678 1.01991992969437 0.636363636363636 18.5 18 5 abnormal epidermis stratum basale morphology 0.00292613930118907 0.0231850238958678 1.01991992969437 0.636363636363636 18.5 18 5 myeloid hyperplasia 0.00292613930118907 0.0231850238958678 1.01991992969437 0.636363636363636 18.5 18 5 respiratory failure 3.31410998934919e-10 1.63244526703091e-08 1.01895501017715 0.635761589403974 18.5 18 5 abnormal intestine morphology 1.07486427951252e-05 0.000195991395099202 1.01795097230113 0.635135135135135 18.5 18 5 decreased susceptibility to hepatic steatosis 4.85131900260721e-05 0.00072261413287338 1.01760718608962 0.634920634920635 18.5 18 5 thrombocytopenia 8.95047755868933e-10 4.1230209124518e-08 1.01690538803024 0.63448275862069 18.5 18 5 abnormal coat/hair pigmentation 7.5412325441273e-08 2.40497640429701e-06 1.01601717486135 0.633928571428571 18.5 18 5 enlarged heart 1.15999633398441e-14 1.20228786699426e-12 1.01552372310086 0.633620689655172 18.5 18 5 liver inflammation 2.82251909898996e-08 9.75141147046879e-07 1.01506316812439 0.633333333333333 18.5 18 5 abnormal incisor morphology 8.06602770288344e-05 0.00112404727792283 1.01506316812439 0.633333333333333 18.5 18 5 abnormal hair cycle 0.00496822117495387 0.0348125356977401 1.01506316812439 0.633333333333333 18.5 18 5 abnormal response to new environment 0.00496822117495387 0.0348125356977401 1.01506316812439 0.633333333333333 18.5 18 5 liver hemorrhage 0.00496822117495387 0.0348125356977401 1.01506316812439 0.633333333333333 18.5 18 5 abnormal cellular respiration 0.00496822117495387 0.0348125356977401 1.01506316812439 0.633333333333333 18.5 18 5 abnormal visceral yolk sac morphology 6.57174648718052e-06 0.000126991881823508 1.01438691018427 0.632911392405063 18.5 18 5 decreased B cell proliferation 6.57174648718052e-06 0.000126991881823508 1.01438691018427 0.632911392405063 18.5 18 5 abnormal myocardium layer morphology 6.57174648718052e-06 0.000126991881823508 1.01438691018427 0.632911392405063 18.5 18 5 abnormal lens morphology 1.0578206695019e-08 4.07957971377671e-07 1.01422841222955 0.6328125 18.5 18 5 perinatal lethality, incomplete penetrance 3.11781560968066e-14 3.10222653163225e-12 1.01411760392493 0.632743362831858 18.5 18 5 absent kidney 0.000370488283778121 0.0043267117647797 1.01397287471073 0.63265306122449 18.5 18 5 increased sarcoma incidence 0.000370488283778121 0.0043267117647797 1.01397287471073 0.63265306122449 18.5 18 5 abnormal respiratory system physiology 0.000370488283778121 0.0043267117647797 1.01397287471073 0.63265306122449 18.5 18 5 decreased circulating alanine transaminase level 2.95322217996693e-05 0.000468398997472145 1.01349186291058 0.632352941176471 18.5 18 5 short limbs 2.4335099379355e-06 5.47815019965118e-05 1.01322094821854 0.632183908045977 18.5 18 5 enlarged spleen 1.26660354331479e-17 2.03269439612616e-15 1.01283715240482 0.631944444444444 18.5 18 5 abnormal craniofacial bone morphology 0.000134184033967084 0.00180277285809743 1.01225135879441 0.631578947368421 18.5 18 5 abnormal retinal outer nuclear layer morphology 0.00173901475285221 0.0153669598498042 1.01225135879441 0.631578947368421 18.5 18 5 abnormal triglyceride level 0.0253117657382245 0.119135321237149 1.01225135879441 0.631578947368421 18.5 18 5 enlarged adrenal glands 0.0253117657382245 0.119135321237149 1.01225135879441 0.631578947368421 18.5 18 5 short vibrissae 0.0253117657382245 0.119135321237149 1.01225135879441 0.631578947368421 18.5 18 5 decreased germ cell number 0.0253117657382245 0.119135321237149 1.01225135879441 0.631578947368421 18.5 18 5 abnormal nasal septum morphology 0.0253117657382245 0.119135321237149 1.01225135879441 0.631578947368421 18.5 18 5 abnormal neural crest cell migration 0.0253117657382245 0.119135321237149 1.01225135879441 0.631578947368421 18.5 18 5 increased susceptibility to ischemic brain injury 0.0253117657382245 0.119135321237149 1.01225135879441 0.631578947368421 18.5 18 5 abnormal optic vesicle formation 0.0253117657382245 0.119135321237149 1.01225135879441 0.631578947368421 18.5 18 5 decreased eye pigmentation 0.0253117657382245 0.119135321237149 1.01225135879441 0.631578947368421 18.5 18 5 decreased liver regeneration 0.0253117657382245 0.119135321237149 1.01225135879441 0.631578947368421 18.5 18 5 Leydig cell hypoplasia 0.0253117657382245 0.119135321237149 1.01225135879441 0.631578947368421 18.5 18 5 decreased susceptibility to weight gain 0.0253117657382245 0.119135321237149 1.01225135879441 0.631578947368421 18.5 18 5 hydronephrosis 4.01750455163798e-06 8.29339632547674e-05 1.01124714117656 0.630952380952381 18.5 18 5 decreased circulating glucose level 5.56959621349637e-17 7.91678318918413e-15 1.01104197843743 0.630824372759857 18.5 18 5 decreased grip strength 1.38825228166345e-13 1.17060255953825e-11 1.00994028263278 0.63013698630137 18.5 18 5 enlarged liver 5.54110283926657e-07 1.39933942260666e-05 1.00972073039742 0.63 18.5 18 5 abnormal small intestine morphology 0.000223357363725998 0.00279899970916081 1.00912712620554 0.62962962962963 18.5 18 5 abnormal neuronal precursor proliferation 0.000223357363725998 0.00279899970916081 1.00912712620554 0.62962962962963 18.5 18 5 abnormal trigeminal nerve morphology 0.00846392903370674 0.0517630685301369 1.00912712620554 0.62962962962963 18.5 18 5 cryptorchism 0.00846392903370674 0.0517630685301369 1.00912712620554 0.62962962962963 18.5 18 5 abnormal palate morphology 0.00846392903370674 0.0517630685301369 1.00912712620554 0.62962962962963 18.5 18 5 abnormal bone trabecula morphology 0.00846392903370674 0.0517630685301369 1.00912712620554 0.62962962962963 18.5 18 5 abnormal behavior 9.2220427770525e-17 1.27443507821767e-14 1.00891359951781 0.629496402877698 18.5 18 5 abnormal kidney morphology 4.94333260678379e-11 2.85966043241272e-09 1.00743111422872 0.628571428571429 18.5 18 5 domed cranium 2.97515745128036e-05 0.000468398997472145 1.00743111422872 0.628571428571429 18.5 18 5 thick epidermis 2.97515745128036e-05 0.000468398997472145 1.00743111422872 0.628571428571429 18.5 18 5 decreased glycogen level 0.00293133266944741 0.0231850238958678 1.00743111422872 0.628571428571429 18.5 18 5 decreased bone mineralization 0.00293133266944741 0.0231850238958678 1.00743111422872 0.628571428571429 18.5 18 5 abnormal left-right axis patterning 0.00103692851642986 0.0100364190063007 1.00636617647584 0.627906976744186 18.5 18 5 delayed endochondral bone ossification 0.00103692851642986 0.0100364190063007 1.00636617647584 0.627906976744186 18.5 18 5 increased blood urea nitrogen level 2.49430595280364e-09 1.07905844479983e-07 1.00585206859513 0.627586206896552 18.5 18 5 abnormal cervical vertebrae morphology 0.000372028139997933 0.00433451989810238 1.0056353368415 0.627450980392157 18.5 18 5 rib fusion 4.9234330872981e-05 0.00072682728811003 1.00469724417654 0.626865671641791 18.5 18 5 delayed bone ossification 1.80830922137328e-05 0.000302555495144753 1.00437829267045 0.626666666666667 18.5 18 5 spleen hyperplasia 1.80830922137328e-05 0.000302555495144753 1.00437829267045 0.626666666666667 18.5 18 5 postnatal growth retardation 3.27581808577744e-34 1.62971949767428e-31 1.00301649481848 0.625816993464052 18.5 18 5 overriding aortic valve 0.000620076985460832 0.00646725996366382 1.00170707380697 0.625 18.5 18 5 increased circulating follicle stimulating hormone level 0.00495166208150823 0.0348125356977401 1.00170707380697 0.625 18.5 18 5 hemolytic anemia 0.0144772751579799 0.0796014808982718 1.00170707380697 0.625 18.5 18 5 abnormal vasodilation 0.0144772751579799 0.0796014808982718 1.00170707380697 0.625 18.5 18 5 abnormal truncus arteriosus septation 0.0144772751579799 0.0796014808982718 1.00170707380697 0.625 18.5 18 5 failure of tooth eruption 0.0442886201369069 0.178663369062033 1.00170707380697 0.625 18.5 18 5 abnormal mouth morphology 0.0442886201369069 0.178663369062033 1.00170707380697 0.625 18.5 18 5 large intestinal inflammation 0.0442886201369069 0.178663369062033 1.00170707380697 0.625 18.5 18 5 increased cochlear outer hair cell number 0.0442886201369069 0.178663369062033 1.00170707380697 0.625 18.5 18 5 small epididymis 0.0442886201369069 0.178663369062033 1.00170707380697 0.625 18.5 18 5 increased thymus weight 0.0442886201369069 0.178663369062033 1.00170707380697 0.625 18.5 18 5 decreased circulating triiodothyronine level 0.0442886201369069 0.178663369062033 1.00170707380697 0.625 18.5 18 5 impaired behavioral response to addictive substance 0.0442886201369069 0.178663369062033 1.00170707380697 0.625 18.5 18 5 abnormal esophageal epithelium morphology 0.150170346064673 0.379660891894382 1.00170707380697 0.625 18.5 18 5 abnormal cecum morphology 0.150170346064673 0.379660891894382 1.00170707380697 0.625 18.5 18 5 absent mammary gland 0.150170346064673 0.379660891894382 1.00170707380697 0.625 18.5 18 5 abnormal pupil morphology 0.150170346064673 0.379660891894382 1.00170707380697 0.625 18.5 18 5 abnormal erythrocyte cell number 0.150170346064673 0.379660891894382 1.00170707380697 0.625 18.5 18 5 abnormal atrial thrombosis 0.150170346064673 0.379660891894382 1.00170707380697 0.625 18.5 18 5 abnormal hepatobiliary system morphology 0.150170346064673 0.379660891894382 1.00170707380697 0.625 18.5 18 5 coarse hair 0.150170346064673 0.379660891894382 1.00170707380697 0.625 18.5 18 5 vascular smooth muscle hypertrophy 0.150170346064673 0.379660891894382 1.00170707380697 0.625 18.5 18 5 short ureter 0.150170346064673 0.379660891894382 1.00170707380697 0.625 18.5 18 5 absent tympanic ring 0.150170346064673 0.379660891894382 1.00170707380697 0.625 18.5 18 5 abnormal cellular cholesterol metabolism 0.150170346064673 0.379660891894382 1.00170707380697 0.625 18.5 18 5 abnormal neuron apoptosis 0.150170346064673 0.379660891894382 1.00170707380697 0.625 18.5 18 5 decreased susceptibility to age related obesity 0.150170346064673 0.379660891894382 1.00170707380697 0.625 18.5 18 5 loss of GABAergic neurons 0.150170346064673 0.379660891894382 1.00170707380697 0.625 18.5 18 5 liver failure 0.150170346064673 0.379660891894382 1.00170707380697 0.625 18.5 18 5 hair follicle degeneration 0.150170346064673 0.379660891894382 1.00170707380697 0.625 18.5 18 5 increased left ventricle systolic pressure 0.150170346064673 0.379660891894382 1.00170707380697 0.625 18.5 18 5 lymph node inflammation 0.150170346064673 0.379660891894382 1.00170707380697 0.625 18.5 18 5 tau protein deposits 0.150170346064673 0.379660891894382 1.00170707380697 0.625 18.5 18 5 absent interparietal bone 0.150170346064673 0.379660891894382 1.00170707380697 0.625 18.5 18 5 absent cochlear microphonics 0.150170346064673 0.379660891894382 1.00170707380697 0.625 18.5 18 5 abnormal choroid pigmentation 0.150170346064673 0.379660891894382 1.00170707380697 0.625 18.5 18 5 increased circulating prolactin level 0.150170346064673 0.379660891894382 1.00170707380697 0.625 18.5 18 5 ocular hypertension 0.150170346064673 0.379660891894382 1.00170707380697 0.625 18.5 18 5 hypergranulosis 0.150170346064673 0.379660891894382 1.00170707380697 0.625 18.5 18 5 abnormal epidermal lamellar body morphology 0.150170346064673 0.379660891894382 1.00170707380697 0.625 18.5 18 5 enlarged inguinal lymph nodes 0.150170346064673 0.379660891894382 1.00170707380697 0.625 18.5 18 5 abnormal olfactory bulb glomerular layer morphology 0.150170346064673 0.379660891894382 1.00170707380697 0.625 18.5 18 5 increased caudal vertebrae number 0.150170346064673 0.379660891894382 1.00170707380697 0.625 18.5 18 5 abnormal circulating serum amyloid protein level 0.150170346064673 0.379660891894382 1.00170707380697 0.625 18.5 18 5 anomalous pulmonary venous connection 0.150170346064673 0.379660891894382 1.00170707380697 0.625 18.5 18 5 sinoatrial block 0.150170346064673 0.379660891894382 1.00170707380697 0.625 18.5 18 5 increased heart right ventricle size 0.150170346064673 0.379660891894382 1.00170707380697 0.625 18.5 18 5 delayed suture closure 0.150170346064673 0.379660891894382 1.00170707380697 0.625 18.5 18 5 lung situs inversus 0.150170346064673 0.379660891894382 1.00170707380697 0.625 18.5 18 5 abnormal anterior commissure pars posterior morphology 0.150170346064673 0.379660891894382 1.00170707380697 0.625 18.5 18 5 abnormal bronchiole epithelium morphology 0.150170346064673 0.379660891894382 1.00170707380697 0.625 18.5 18 5 abnormal pulmonary acinus morphology 0.150170346064673 0.379660891894382 1.00170707380697 0.625 18.5 18 5 abnormal bronchus epithelium morphology 0.150170346064673 0.379660891894382 1.00170707380697 0.625 18.5 18 5 absent ureteric bud 0.150170346064673 0.379660891894382 1.00170707380697 0.625 18.5 18 5 abnormal branching involved in ureteric bud morphogenesis 0.150170346064673 0.379660891894382 1.00170707380697 0.625 18.5 18 5 decreased surfactant secretion 0.150170346064673 0.379660891894382 1.00170707380697 0.625 18.5 18 5 increased aorta wall thickness 0.150170346064673 0.379660891894382 1.00170707380697 0.625 18.5 18 5 increased circulating lactate level 0.150170346064673 0.379660891894382 1.00170707380697 0.625 18.5 18 5 small thymus medulla 0.150170346064673 0.379660891894382 1.00170707380697 0.625 18.5 18 5 increased mammary gland apoptosis 0.150170346064673 0.379660891894382 1.00170707380697 0.625 18.5 18 5 decreased white adipose tissue mass 0.150170346064673 0.379660891894382 1.00170707380697 0.625 18.5 18 5 decreased vascular endothelial cell proliferation 0.150170346064673 0.379660891894382 1.00170707380697 0.625 18.5 18 5 abnormal enzyme/coenzyme activity 9.48039233613227e-10 4.287722897478e-08 1.00043101384033 0.624203821656051 18.5 18 5 polyuria 1.81229221212334e-05 0.000302555495144753 0.999105237251624 0.623376623376623 18.5 18 5 abnormal lung morphology 1.28370256426348e-07 3.87055773164292e-06 0.996656449905419 0.621848739495798 18.5 18 5 abnormal angiogenesis 2.9864065710113e-05 0.000468686835671332 0.996292440975577 0.621621621621622 18.5 18 5 abnormal chromosome morphology 0.00291611908327166 0.0231850238958678 0.996292440975577 0.621621621621622 18.5 18 5 increased trabecular bone volume 0.00291611908327166 0.0231850238958678 0.996292440975577 0.621621621621622 18.5 18 5 limb grasping 8.28258450197295e-11 4.57842865525727e-09 0.995102411781865 0.620879120879121 18.5 18 5 abnormal glucose homeostasis 8.28258450197295e-11 4.57842865525727e-09 0.995102411781865 0.620879120879121 18.5 18 5 abnormal blood vessel morphology 6.75365403265985e-09 2.68795430499862e-07 0.994798749160022 0.620689655172414 18.5 18 5 abnormal spleen morphology 2.20012286540347e-10 1.11087067052052e-08 0.994798749160022 0.620689655172414 18.5 18 5 lordosis 0.00838477664785196 0.0516265641374548 0.994798749160022 0.620689655172414 18.5 18 5 abnormal embryonic erythropoiesis 0.00838477664785196 0.0516265641374548 0.994798749160022 0.620689655172414 18.5 18 5 polychromatophilia 0.00838477664785196 0.0516265641374548 0.994798749160022 0.620689655172414 18.5 18 5 blood in lymph vessels 0.00838477664785196 0.0516265641374548 0.994798749160022 0.620689655172414 18.5 18 5 decreased leukocyte cell number 1.80024742793708e-08 6.3973078242764e-07 0.994395343341222 0.62043795620438 18.5 18 5 short stride length 0.000617583909891801 0.0064547898145204 0.993693417216511 0.62 18.5 18 5 testicular atrophy 0.000617583909891801 0.0064547898145204 0.993693417216511 0.62 18.5 18 5 abnormal axon extension 0.000617583909891801 0.0064547898145204 0.993693417216511 0.62 18.5 18 5 increased circulating cholesterol level 2.20045044922293e-10 1.11087067052052e-08 0.992600645863267 0.619318181818182 18.5 18 5 spleen hypoplasia 9.2130924649704e-07 2.25788842429693e-05 0.992167006437376 0.619047619047619 18.5 18 5 abnormal hair follicle morphology 0.000134437935749578 0.00180277285809743 0.992167006437376 0.619047619047619 18.5 18 5 abnormal pancreas morphology 0.00172639180480943 0.0153000192477121 0.992167006437376 0.619047619047619 18.5 18 5 abnormal vibrissa morphology 0.00172639180480943 0.0153000192477121 0.992167006437376 0.619047619047619 18.5 18 5 increased keratinocyte proliferation 0.0248831796698686 0.119135321237149 0.992167006437376 0.619047619047619 18.5 18 5 abnormal myocardial fiber morphology 2.4759152716391e-06 5.54850381820024e-05 0.99138019675741 0.618556701030928 18.5 18 5 decreased circulating calcium level 0.000369809360444172 0.0043267117647797 0.990779360274527 0.618181818181818 18.5 18 5 hypoactivity 2.4398997023604e-20 6.06925050962149e-18 0.99054747245421 0.618037135278515 18.5 18 5 decreased body weight 2.49138820412196e-64 4.85794483577157e-61 0.990379207059553 0.617932148626817 18.5 18 5 premature death 8.73058607360316e-45 7.23911095269595e-42 0.990305529877456 0.617886178861789 18.5 18 5 impaired balance 1.50744534052191e-06 3.53751913636627e-05 0.989922284703355 0.617647058823529 18.5 18 5 abnormal oocyte morphology 0.00490053473696719 0.0348125356977401 0.989922284703355 0.617647058823529 18.5 18 5 abnormal spleen red pulp morphology 0.00490053473696719 0.0348125356977401 0.989922284703355 0.617647058823529 18.5 18 5 abnormal skeleton morphology 3.42714733353576e-07 9.06917977890447e-06 0.989512378995403 0.617391304347826 18.5 18 5 pulmonary hypoplasia 0.0010264143008301 0.00997345927076122 0.98891932392858 0.617021276595745 18.5 18 5 epidermal hyperplasia 0.000221972289313414 0.00279572693502337 0.98835097948954 0.616666666666667 18.5 18 5 absent mesoderm 0.000221972289313414 0.00279572693502337 0.98835097948954 0.616666666666667 18.5 18 5 intracranial hemorrhage 0.000221972289313414 0.00279572693502337 0.98835097948954 0.616666666666667 18.5 18 5 decreased hematocrit 1.09759077955336e-08 4.20039548329074e-07 0.987985059097282 0.616438356164384 18.5 18 5 decreased bone marrow cell number 4.89489814612929e-05 0.000724765424910512 0.987985059097282 0.616438356164384 18.5 18 5 astrocytosis 4.89489814612929e-05 0.000724765424910512 0.987985059097282 0.616438356164384 18.5 18 5 increased or absent threshold for auditory brainstem response 1.10931702365356e-15 1.34606151040889e-13 0.987149393149564 0.615916955017301 18.5 18 5 increased urine protein level 2.95969752431973e-05 0.000468398997472145 0.986296195748398 0.615384615384615 18.5 18 5 abnormal heart ventricle morphology 2.95969752431973e-05 0.000468398997472145 0.986296195748398 0.615384615384615 18.5 18 5 abnormal heart looping 0.00288399413241373 0.0231681238718336 0.986296195748398 0.615384615384615 18.5 18 5 abnormal iris morphology 0.00288399413241373 0.0231681238718336 0.986296195748398 0.615384615384615 18.5 18 5 failure of heart looping 0.00288399413241373 0.0231681238718336 0.986296195748398 0.615384615384615 18.5 18 5 abnormal nasal bone morphology 0.0142377495721096 0.0795694131031198 0.986296195748398 0.615384615384615 18.5 18 5 abnormal xiphoid process morphology 0.0142377495721096 0.0795694131031198 0.986296195748398 0.615384615384615 18.5 18 5 abnormal Schwann cell morphology 0.0142377495721096 0.0795694131031198 0.986296195748398 0.615384615384615 18.5 18 5 thick skin 0.0142377495721096 0.0795694131031198 0.986296195748398 0.615384615384615 18.5 18 5 increased susceptibility to otitis media 0.0142377495721096 0.0795694131031198 0.986296195748398 0.615384615384615 18.5 18 5 abnormal erythrocyte osmotic lysis 0.0142377495721096 0.0795694131031198 0.986296195748398 0.615384615384615 18.5 18 5 short premaxilla 0.0783950952677128 0.262897574327077 0.986296195748398 0.615384615384615 18.5 18 5 absent common myeloid progenitor cells 0.0783950952677128 0.262897574327077 0.986296195748398 0.615384615384615 18.5 18 5 absent trabeculae carneae 0.0783950952677128 0.262897574327077 0.986296195748398 0.615384615384615 18.5 18 5 uterus hypoplasia 0.0783950952677128 0.262897574327077 0.986296195748398 0.615384615384615 18.5 18 5 increased pituitary adenoma incidence 0.0783950952677128 0.262897574327077 0.986296195748398 0.615384615384615 18.5 18 5 abnormal pulmonary alveolus epithelial cell morphology 0.0783950952677128 0.262897574327077 0.986296195748398 0.615384615384615 18.5 18 5 dystrophic cardiac calcinosis 0.0783950952677128 0.262897574327077 0.986296195748398 0.615384615384615 18.5 18 5 abnormal telomere length 0.0783950952677128 0.262897574327077 0.986296195748398 0.615384615384615 18.5 18 5 axonal dystrophy 0.0783950952677128 0.262897574327077 0.986296195748398 0.615384615384615 18.5 18 5 tracheoesophageal fistula 0.0783950952677128 0.262897574327077 0.986296195748398 0.615384615384615 18.5 18 5 abnormal vestibulocochlear ganglion morphology 0.0783950952677128 0.262897574327077 0.986296195748398 0.615384615384615 18.5 18 5 small otic vesicle 0.0783950952677128 0.262897574327077 0.986296195748398 0.615384615384615 18.5 18 5 increased cochlear inner hair cell number 0.0783950952677128 0.262897574327077 0.986296195748398 0.615384615384615 18.5 18 5 abnormal exocrine pancreas morphology 0.0783950952677128 0.262897574327077 0.986296195748398 0.615384615384615 18.5 18 5 abnormal vertebral arch development 0.0783950952677128 0.262897574327077 0.986296195748398 0.615384615384615 18.5 18 5 increased circulating thyroxine level 0.0783950952677128 0.262897574327077 0.986296195748398 0.615384615384615 18.5 18 5 abnormal aorta tunica media morphology 0.0783950952677128 0.262897574327077 0.986296195748398 0.615384615384615 18.5 18 5 decreased cardiac stroke volume 0.0783950952677128 0.262897574327077 0.986296195748398 0.615384615384615 18.5 18 5 abnormal rib morphology 4.76067151553171e-08 1.55818031511647e-06 0.985382958530112 0.614814814814815 18.5 18 5 hyperglycemia 1.08574289618562e-05 0.000196420760309943 0.983494217919567 0.613636363636364 18.5 18 5 abnormal myelopoiesis 0.00170648156034547 0.0152551815683482 0.983494217919567 0.613636363636364 18.5 18 5 hypoglycemia 6.58570965034471e-06 0.000126991881823508 0.98231919495909 0.612903225806452 18.5 18 5 osteopetrosis 0.00824829183902733 0.0516265641374548 0.98231919495909 0.612903225806452 18.5 18 5 increased lung adenoma incidence 0.00824829183902733 0.0516265641374548 0.98231919495909 0.612903225806452 18.5 18 5 abnormal nose morphology 0.00824829183902733 0.0516265641374548 0.98231919495909 0.612903225806452 18.5 18 5 decreased neuronal precursor cell number 0.00824829183902733 0.0516265641374548 0.98231919495909 0.612903225806452 18.5 18 5 postnatal lethality, incomplete penetrance 1.14919741593161e-28 4.76438095354978e-26 0.981955103337533 0.612676056338028 18.5 18 5 decreased circulating creatinine level 0.00101416440917038 0.00987371415973119 0.981264072300702 0.612244897959184 18.5 18 5 maternal effect 0.000132167392135539 0.00178193164193579 0.980775881219955 0.611940298507463 18.5 18 5 abnormal bone mineralization 3.36280070496898e-07 8.99458790710788e-06 0.980182789576403 0.611570247933884 18.5 18 5 increased heart weight 4.69366029415228e-08 1.54642118962964e-06 0.980087496674442 0.611510791366906 18.5 18 5 abnormal neuromuscular synapse morphology 7.96068708168503e-05 0.00111248365818492 0.979446916611256 0.611111111111111 18.5 18 5 heart right ventricle hypertrophy 0.00482171203329961 0.0344655421920482 0.979446916611256 0.611111111111111 18.5 18 5 abnormal uterus morphology 0.00482171203329961 0.0344655421920482 0.979446916611256 0.611111111111111 18.5 18 5 abnormal epidermis stratum granulosum morphology 0.00482171203329961 0.0344655421920482 0.979446916611256 0.611111111111111 18.5 18 5 abnormal radius morphology 0.0430233493097778 0.178663369062033 0.979446916611256 0.611111111111111 18.5 18 5 abnormal mammary gland morphology 0.0430233493097778 0.178663369062033 0.979446916611256 0.611111111111111 18.5 18 5 abnormal redox activity 0.0430233493097778 0.178663369062033 0.979446916611256 0.611111111111111 18.5 18 5 increased circulating renin level 0.0430233493097778 0.178663369062033 0.979446916611256 0.611111111111111 18.5 18 5 abnormal neutrophil morphology 0.0430233493097778 0.178663369062033 0.979446916611256 0.611111111111111 18.5 18 5 jerky movement 0.0430233493097778 0.178663369062033 0.979446916611256 0.611111111111111 18.5 18 5 abnormal glycogen homeostasis 0.0430233493097778 0.178663369062033 0.979446916611256 0.611111111111111 18.5 18 5 small thoracic cage 0.0430233493097778 0.178663369062033 0.979446916611256 0.611111111111111 18.5 18 5 decreased tumor latency 0.0430233493097778 0.178663369062033 0.979446916611256 0.611111111111111 18.5 18 5 atrioventricular block 0.0430233493097778 0.178663369062033 0.979446916611256 0.611111111111111 18.5 18 5 decreased insulin secretion 1.07549046958959e-05 0.000195991395099202 0.979446916611256 0.611111111111111 18.5 18 5 abnormal mandible morphology 0.000604891794065558 0.00636223398620751 0.979446916611256 0.611111111111111 18.5 18 5 increased hemoglobin content 0.000361870782841474 0.00429667576285521 0.977937753411547 0.610169491525424 18.5 18 5 hemopericardium 0.0028380219831087 0.0229792943333823 0.977275193958016 0.609756097560976 18.5 18 5 decreased circulating LDL cholesterol level 0.000217038359867471 0.00276863035984786 0.976664396961792 0.609375 18.5 18 5 abnormal coat appearance 0.000130457264723642 0.00176365459782642 0.975575584925046 0.608695652173913 18.5 18 5 abnormal circulating insulin level 0.0242539569320529 0.117257213295407 0.975575584925045 0.608695652173913 18.5 18 5 abnormal postnatal growth 0.0242539569320529 0.117257213295407 0.975575584925045 0.608695652173913 18.5 18 5 abnormal nasal cavity morphology 0.0242539569320529 0.117257213295407 0.975575584925045 0.608695652173913 18.5 18 5 distended abdomen 0.000998195353227296 0.00975642805953988 0.974209232565206 0.607843137254902 18.5 18 5 enhanced long term potentiation 0.000595407010176347 0.0062757412619223 0.973086871698196 0.607142857142857 18.5 18 5 shortened head 0.0139066662181748 0.0790693307833369 0.973086871698196 0.607142857142857 18.5 18 5 straub tail 0.0139066662181748 0.0790693307833369 0.973086871698196 0.607142857142857 18.5 18 5 abnormal retinal inner nuclear layer morphology 0.0139066662181748 0.0790693307833369 0.973086871698196 0.607142857142857 18.5 18 5 respiratory distress 2.38490069213031e-09 1.04077903011827e-07 0.972756002309655 0.606936416184971 18.5 18 5 kyphosis 2.77339364202927e-08 9.71664321767297e-07 0.972323666308629 0.606666666666667 18.5 18 5 decreased body size 8.35222835808413e-38 5.19404201018357e-35 0.972082654080344 0.606516290726817 18.5 18 5 insulin resistance 1.97985016199184e-07 5.61466137020138e-06 0.971352313994634 0.606060606060606 18.5 18 5 abnormal ovarian folliculogenesis 0.00806785097430695 0.0516265641374548 0.971352313994634 0.606060606060606 18.5 18 5 increased osteoblast cell number 0.00806785097430695 0.0516265641374548 0.971352313994634 0.606060606060606 18.5 18 5 abnormal renal glomerulus morphology 2.34146158935639e-06 5.29489609411274e-05 0.970461165082712 0.605504587155963 18.5 18 5 abnormal frontal bone morphology 0.0047210123899148 0.0339099420584614 0.970074218844641 0.605263157894737 18.5 18 5 increased bone marrow cell number 0.0047210123899148 0.0339099420584614 0.970074218844641 0.605263157894737 18.5 18 5 incomplete somite formation 0.0047210123899148 0.0339099420584614 0.970074218844641 0.605263157894737 18.5 18 5 abnormal reproductive system physiology 0.0047210123899148 0.0339099420584614 0.970074218844641 0.605263157894737 18.5 18 5 increased exploration in new environment 4.66548833369124e-05 0.000697021154958376 0.969553513413162 0.604938271604938 18.5 18 5 abnormal cranium morphology 1.95161980017051e-07 5.58006235968292e-06 0.968815199741663 0.604477611940298 18.5 18 5 reduced fertility 1.18919304137433e-07 3.65102726502928e-06 0.968557055537095 0.60431654676259 18.5 18 5 abnormal hair shaft morphology 0.00164661336113054 0.0148135650481455 0.968316838013401 0.604166666666667 18.5 18 5 abnormal mesoderm development 0.000979127647927011 0.0096682450642656 0.967686833564466 0.60377358490566 18.5 18 5 glomerulosclerosis 0.000584255359229755 0.00622413364489942 0.967165450572243 0.603448275862069 18.5 18 5 pericardial edema 0.000209773676297425 0.0026897526793291 0.966352706496132 0.602941176470588 18.5 18 5 lethargy 1.67514146845867e-05 0.000285405096081571 0.965085524872088 0.602150537634409 18.5 18 5 impaired glucose tolerance 3.69597195850531e-12 2.58978316810759e-10 0.962931316111213 0.600806451612903 18.5 18 5 abnormal retina morphology 1.85509192526644e-10 9.71482350336901e-09 0.961638790854688 0.6 18.5 18 5 muscular ventricular septal defect 0.000571718523133568 0.00610364732315344 0.961638790854688 0.6 18.5 18 5 abnormal rostral-caudal axis patterning 0.000957515444497634 0.00958478739713426 0.961638790854688 0.6 18.5 18 5 abnormal heart tube morphology 0.0135096098571992 0.0776997792364924 0.961638790854688 0.6 18.5 18 5 abnormal lactation 0.0135096098571992 0.0776997792364924 0.961638790854688 0.6 18.5 18 5 abnormal fat pad morphology 0.0135096098571992 0.0776997792364924 0.961638790854688 0.6 18.5 18 5 audiogenic seizures 0.0749406894644424 0.257279635540005 0.961638790854688 0.6 18.5 18 5 dilated ureter 0.0749406894644424 0.257279635540005 0.961638790854688 0.6 18.5 18 5 abnormal rostral migratory stream morphology 0.0749406894644424 0.257279635540005 0.961638790854688 0.6 18.5 18 5 abnormal energy homeostasis 0.0749406894644424 0.257279635540005 0.961638790854688 0.6 18.5 18 5 decreased thymocyte apoptosis 0.0749406894644424 0.257279635540005 0.961638790854688 0.6 18.5 18 5 liver vascular congestion 0.0749406894644424 0.257279635540005 0.961638790854688 0.6 18.5 18 5 bicuspid aortic valve 0.0749406894644424 0.257279635540005 0.961638790854688 0.6 18.5 18 5 abnormal coronary vessel morphology 0.0749406894644424 0.257279635540005 0.961638790854688 0.6 18.5 18 5 abnormal microglial cell activation 0.0749406894644424 0.257279635540005 0.961638790854688 0.6 18.5 18 5 alopecia 1.64316264976712e-05 0.000281489150169774 0.961638790854688 0.6 18.5 18 5 increased inflammatory response 1.64316264976712e-05 0.000281489150169774 0.961638790854688 0.6 18.5 18 5 abnormal retinal pigment epithelium morphology 7.44630606563069e-05 0.00104647945413878 0.961638790854688 0.6 18.5 18 5 increased body length 0.00160903515808825 0.014580965230399 0.961638790854688 0.6 18.5 18 5 decreased respiratory quotient 0.00160903515808825 0.014580965230399 0.961638790854688 0.6 18.5 18 5 abnormal ectoderm development 0.00271482071515433 0.0224356030862006 0.961638790854688 0.6 18.5 18 5 cardiomyopathy 0.00271482071515433 0.0224356030862006 0.961638790854688 0.6 18.5 18 5 abnormal pancreatic beta cell morphology 0.00460333221966755 0.0334329602815271 0.961638790854688 0.6 18.5 18 5 thick pulmonary interalveolar septum 0.00785433783824686 0.0510121811296059 0.961638790854688 0.6 18.5 18 5 ovary cysts 0.00785433783824686 0.0510121811296059 0.961638790854688 0.6 18.5 18 5 holoprosencephaly 0.00785433783824686 0.0510121811296059 0.961638790854688 0.6 18.5 18 5 abnormal hippocampus pyramidal cell morphology 0.00785433783824686 0.0510121811296059 0.961638790854688 0.6 18.5 18 5 abnormal nest building behavior 0.023489126251674 0.114008198148369 0.961638790854688 0.6 18.5 18 5 abnormal energy expenditure 0.023489126251674 0.114008198148369 0.961638790854688 0.6 18.5 18 5 abnormal basioccipital bone morphology 0.0414690474967942 0.174986014670527 0.961638790854688 0.6 18.5 18 5 abnormal circulating enzyme level 0.0414690474967942 0.174986014670527 0.961638790854688 0.6 18.5 18 5 increased urine glucose level 0.0414690474967942 0.174986014670527 0.961638790854688 0.6 18.5 18 5 abnormal hair texture 0.0414690474967942 0.174986014670527 0.961638790854688 0.6 18.5 18 5 abnormal Peyer's patch T cell area morphology 0.0414690474967942 0.174986014670527 0.961638790854688 0.6 18.5 18 5 abnormal neuron proliferation 0.0414690474967942 0.174986014670527 0.961638790854688 0.6 18.5 18 5 retarded hair growth 0.141026851482519 0.379660891894382 0.961638790854688 0.6 18.5 18 5 enlarged testis 0.141026851482519 0.379660891894382 0.961638790854688 0.6 18.5 18 5 abnormal prostate gland epithelium morphology 0.141026851482519 0.379660891894382 0.961638790854688 0.6 18.5 18 5 fused cornea and lens 0.141026851482519 0.379660891894382 0.961638790854688 0.6 18.5 18 5 absent trophoblast giant cells 0.141026851482519 0.379660891894382 0.961638790854688 0.6 18.5 18 5 rhinitis 0.141026851482519 0.379660891894382 0.961638790854688 0.6 18.5 18 5 decreased incidence of induced tumors 0.141026851482519 0.379660891894382 0.961638790854688 0.6 18.5 18 5 abnormal respiratory mechanics 0.141026851482519 0.379660891894382 0.961638790854688 0.6 18.5 18 5 increased atrioventricular cushion size 0.141026851482519 0.379660891894382 0.961638790854688 0.6 18.5 18 5 abnormal pillar cell morphology 0.141026851482519 0.379660891894382 0.961638790854688 0.6 18.5 18 5 abnormal hindlimb zeugopod morphology 0.141026851482519 0.379660891894382 0.961638790854688 0.6 18.5 18 5 increased defecation amount 0.141026851482519 0.379660891894382 0.961638790854688 0.6 18.5 18 5 abnormal embryonic erythrocyte morphology 0.141026851482519 0.379660891894382 0.961638790854688 0.6 18.5 18 5 abnormal utricular macula morphology 0.141026851482519 0.379660891894382 0.961638790854688 0.6 18.5 18 5 decreased cochlear inner hair cell number 0.141026851482519 0.379660891894382 0.961638790854688 0.6 18.5 18 5 decreased thyroxine level 0.141026851482519 0.379660891894382 0.961638790854688 0.6 18.5 18 5 protruding tongue 0.141026851482519 0.379660891894382 0.961638790854688 0.6 18.5 18 5 abnormal retinal blood vessel pattern 0.141026851482519 0.379660891894382 0.961638790854688 0.6 18.5 18 5 abnormal vibrissa follicle morphology 0.141026851482519 0.379660891894382 0.961638790854688 0.6 18.5 18 5 thick aortic valve cusps 0.141026851482519 0.379660891894382 0.961638790854688 0.6 18.5 18 5 decreased circulating lactate level 0.141026851482519 0.379660891894382 0.961638790854688 0.6 18.5 18 5 sparse hair 7.28457667694491e-05 0.00103250054039319 0.957729690078856 0.597560975609756 18.5 18 5 abnormal blood homeostasis 3.51230753151262e-06 7.4550650485096e-05 0.956015172194719 0.596491228070175 18.5 18 5 abnormal skin condition 0.00156770555722881 0.0143370131382598 0.95547443963126 0.596153846153846 18.5 18 5 decreased body temperature 0.00156770555722881 0.0143370131382598 0.95547443963126 0.596153846153846 18.5 18 5 deafness 1.57335903816987e-05 0.000273687455066262 0.95516310876139 0.595959595959596 18.5 18 5 decreased circulating cholesterol level 5.38331621617895e-09 2.17739822564962e-07 0.954632315147185 0.595628415300546 18.5 18 5 skin edema 0.00447277224531349 0.0327924919927197 0.954006736959016 0.595238095238095 18.5 18 5 increased granulocyte number 0.000195875171244491 0.00256441836037195 0.952975378324465 0.594594594594595 18.5 18 5 abnormal humerus morphology 0.00761658169334057 0.0500561346424958 0.952975378324465 0.594594594594595 18.5 18 5 retinal degeneration 2.53597213531622e-05 0.000408299720815476 0.951621720116618 0.59375 18.5 18 5 abnormal urine homeostasis 2.53597213531622e-05 0.000408299720815476 0.951621720116618 0.59375 18.5 18 5 scoliosis 0.0130664430230937 0.0754124756843283 0.951621720116618 0.59375 18.5 18 5 abnormal heart atrium morphology 0.0130664430230937 0.0754124756843283 0.951621720116618 0.59375 18.5 18 5 abnormal thoracic vertebrae morphology 0.000908566199795995 0.00913154917976783 0.950772815816782 0.593220338983051 18.5 18 5 abnormal long bone epiphyseal plate proliferative zone 0.00152347070808912 0.0140151075643893 0.949766707016976 0.592592592592593 18.5 18 5 abnormal atrioventricular cushion morphology 0.0226360339916047 0.110406146184543 0.949766707016976 0.592592592592593 18.5 18 5 rectal prolapse 0.0226360339916047 0.110406146184543 0.949766707016976 0.592592592592593 18.5 18 5 abnormal brain commissure morphology 0.0226360339916047 0.110406146184543 0.949766707016976 0.592592592592593 18.5 18 5 abnormal type II pneumocyte morphology 0.0226360339916047 0.110406146184543 0.949766707016976 0.592592592592593 18.5 18 5 abnormal spermatogenesis 8.22459408088316e-09 3.22183901987352e-07 0.949444096043125 0.592391304347826 18.5 18 5 abnormal lipid homeostasis 1.20943938311539e-06 2.90674441111066e-05 0.949310088407833 0.592307692307692 18.5 18 5 increased circulating LDL cholesterol level 0.00256366434147279 0.0215443075993702 0.948555269890678 0.591836734693878 18.5 18 5 embryonic lethality, incomplete penetrance 0.00433275236023199 0.0318867499883937 0.947068506144768 0.590909090909091 18.5 18 5 abnormal abdominal fat pad morphology 0.0397478248428186 0.172617348576253 0.947068506144768 0.590909090909091 18.5 18 5 abnormal chorion morphology 0.0397478248428186 0.172617348576253 0.947068506144768 0.590909090909091 18.5 18 5 aphakia 0.0397478248428186 0.172617348576253 0.947068506144768 0.590909090909091 18.5 18 5 abnormal cochlear sensory epithelium morphology 0.0397478248428186 0.172617348576253 0.947068506144768 0.590909090909091 18.5 18 5 decreased cardiac output 0.0397478248428186 0.172617348576253 0.947068506144768 0.590909090909091 18.5 18 5 abnormal blood-brain barrier function 0.0397478248428186 0.172617348576253 0.947068506144768 0.590909090909091 18.5 18 5 cleft upper lip 0.0397478248428186 0.172617348576253 0.947068506144768 0.590909090909091 18.5 18 5 decreased circulating estradiol level 0.0397478248428186 0.172617348576253 0.947068506144768 0.590909090909091 18.5 18 5 rough coat 0.0397478248428186 0.172617348576253 0.947068506144768 0.590909090909091 18.5 18 5 decreased bone mineral density 7.30139468730854e-12 4.97595048895343e-10 0.945972996016203 0.590225563909774 18.5 18 5 abnormal liver physiology 2.40519208518452e-05 0.000391040216463824 0.945611477673776 0.59 18.5 18 5 decreased double-positive T cell number 2.40519208518452e-05 0.000391040216463824 0.945611477673776 0.59 18.5 18 5 decreased heart rate 2.40519208518452e-05 0.000391040216463824 0.945611477673776 0.59 18.5 18 5 decreased startle reflex 5.23390941238899e-06 0.000106280405414838 0.945200520925548 0.58974358974359 18.5 18 5 small lens 0.00736172613507263 0.048445221589929 0.945200520925548 0.58974358974359 18.5 18 5 acanthosis 0.00736172613507263 0.048445221589929 0.945200520925548 0.58974358974359 18.5 18 5 weight loss 3.33684403525019e-08 1.14488269485308e-06 0.943321861505075 0.588571428571429 18.5 18 5 short maxilla 0.0125925884562209 0.0739647314872479 0.94278312828891 0.588235294117647 18.5 18 5 lung hemorrhage 0.0125925884562209 0.0739647314872479 0.94278312828891 0.588235294117647 18.5 18 5 impaired synaptic plasticity 0.0125925884562209 0.0739647314872479 0.94278312828891 0.588235294117647 18.5 18 5 distended urinary bladder 0.0712013219344533 0.254839263758205 0.94278312828891 0.588235294117647 18.5 18 5 abnormal duodenum morphology 0.0712013219344533 0.254839263758205 0.94278312828891 0.588235294117647 18.5 18 5 abnormal embryonic-extraembryonic boundary morphology 0.0712013219344533 0.254839263758205 0.94278312828891 0.588235294117647 18.5 18 5 coloboma 0.0712013219344533 0.254839263758205 0.94278312828891 0.588235294117647 18.5 18 5 delayed heart development 0.0712013219344533 0.254839263758205 0.94278312828891 0.588235294117647 18.5 18 5 small testis 6.38850125055393e-12 4.41427690576469e-10 0.940733599749151 0.58695652173913 18.5 18 5 abnormal locomotor behavior 6.36887102549475e-05 0.000923764820753247 0.940733599749151 0.58695652173913 18.5 18 5 abnormal neurocranium morphology 0.000298484728510646 0.00364329708068706 0.940269039946806 0.586666666666667 18.5 18 5 abnormal limb morphology 0.000298484728510646 0.00364329708068706 0.940269039946806 0.586666666666667 18.5 18 5 cachexia 2.26968983349094e-05 0.000373897580186008 0.940063561572692 0.586538461538462 18.5 18 5 aphagia 0.0217293431094655 0.10773445741568 0.939532151984465 0.586206896551724 18.5 18 5 decreased lymphocyte cell number 2.9227785677759e-06 6.3834387079043e-05 0.939100381694031 0.5859375 18.5 18 5 Leydig cell hyperplasia 0.00709553490657414 0.0473194184453168 0.938184186199695 0.585365853658537 18.5 18 5 abnormal pancreatic islet morphology 0.0023970653385177 0.0202468591835748 0.937446620015576 0.584905660377358 18.5 18 5 neonatal lethality, incomplete penetrance 4.27217195278053e-11 2.53024469822419e-09 0.936981385960978 0.584615384615385 18.5 18 5 ataxia 6.43431691059065e-09 2.58151021211197e-07 0.936248987795818 0.584158415841584 18.5 18 5 abnormal pulmonary alveolus morphology 3.62599945760595e-05 0.000558493724507419 0.936248987795818 0.584158415841584 18.5 18 5 impaired coordination 3.58771704787421e-14 3.43247929099503e-12 0.935698630793097 0.583815028901734 18.5 18 5 cyanosis 1.71537115489407e-08 6.22917627415912e-07 0.934926602219835 0.583333333333333 18.5 18 5 abnormal heart left ventricle morphology 0.000479778899196243 0.00532790183817257 0.934926602219835 0.583333333333333 18.5 18 5 cochlear outer hair cell degeneration 0.000479778899196243 0.00532790183817257 0.934926602219835 0.583333333333333 18.5 18 5 abnormal eating behavior 0.00138015294712338 0.012786333169346 0.934926602219835 0.583333333333333 18.5 18 5 abnormal limb bone morphology 0.012100013965173 0.0714087419652854 0.934926602219835 0.583333333333333 18.5 18 5 abnormal digestive system morphology 0.0379413114157549 0.167338674018954 0.934926602219835 0.583333333333333 18.5 18 5 decreased body height 0.0379413114157549 0.167338674018954 0.934926602219835 0.583333333333333 18.5 18 5 abnormal nursing 0.0379413114157549 0.167338674018954 0.934926602219835 0.583333333333333 18.5 18 5 prolonged QT interval 0.0379413114157549 0.167338674018954 0.934926602219835 0.583333333333333 18.5 18 5 abnormal adipose tissue distribution 0.131764836410077 0.379660891894382 0.934926602219835 0.583333333333333 18.5 18 5 abnormal rectum morphology 0.131764836410077 0.379660891894382 0.934926602219835 0.583333333333333 18.5 18 5 amyloidosis 0.131764836410077 0.379660891894382 0.934926602219835 0.583333333333333 18.5 18 5 abnormal glossopharyngeal nerve morphology 0.131764836410077 0.379660891894382 0.934926602219835 0.583333333333333 18.5 18 5 abnormal mating frequency 0.131764836410077 0.379660891894382 0.934926602219835 0.583333333333333 18.5 18 5 abnormal pilomotor reflex 0.131764836410077 0.379660891894382 0.934926602219835 0.583333333333333 18.5 18 5 impaired embryo implantation 0.131764836410077 0.379660891894382 0.934926602219835 0.583333333333333 18.5 18 5 increased growth rate 0.131764836410077 0.379660891894382 0.934926602219835 0.583333333333333 18.5 18 5 decreased synaptic depression 0.131764836410077 0.379660891894382 0.934926602219835 0.583333333333333 18.5 18 5 abnormal alisphenoid bone morphology 0.131764836410077 0.379660891894382 0.934926602219835 0.583333333333333 18.5 18 5 small intestinal inflammation 0.131764836410077 0.379660891894382 0.934926602219835 0.583333333333333 18.5 18 5 decreased circulating ketone body level 0.131764836410077 0.379660891894382 0.934926602219835 0.583333333333333 18.5 18 5 abnormal nucleotide metabolism 0.131764836410077 0.379660891894382 0.934926602219835 0.583333333333333 18.5 18 5 decreased left ventricle systolic pressure 0.131764836410077 0.379660891894382 0.934926602219835 0.583333333333333 18.5 18 5 absent cochlear hair cells 0.131764836410077 0.379660891894382 0.934926602219835 0.583333333333333 18.5 18 5 abnormal cochlear outer hair cell physiology 0.131764836410077 0.379660891894382 0.934926602219835 0.583333333333333 18.5 18 5 impaired behavioral response to cocaine 0.131764836410077 0.379660891894382 0.934926602219835 0.583333333333333 18.5 18 5 abnormal vitelline vein connection 0.131764836410077 0.379660891894382 0.934926602219835 0.583333333333333 18.5 18 5 abnormal spatial learning 2.12560568714361e-07 5.9745131601918e-06 0.934107209930423 0.582822085889571 18.5 18 5 abnormal nervous system physiology 1.25535175443403e-05 0.000220684628208809 0.933765202713972 0.582608695652174 18.5 18 5 small ovary 9.86709381551712e-05 0.00135230831218175 0.933458899547591 0.582417582417582 18.5 18 5 abnormal contextual conditioning behavior 0.00231088672699902 0.0195854539468827 0.932498221434849 0.581818181818182 18.5 18 5 decreased oxygen consumption 0.00682264332298509 0.045683244322814 0.931820533773922 0.581395348837209 18.5 18 5 increased circulating HDL cholesterol level 3.39437929343022e-05 0.000529374200150951 0.931110575271999 0.580952380952381 18.5 18 5 abnormal podocyte morphology 0.0207945117285141 0.107093888042813 0.930618184698085 0.580645161290323 18.5 18 5 no abnormal phenotype detected 2.92941397131954e-64 4.85794483577157e-61 0.929307035158324 0.579827089337176 18.5 18 5 increased macrophage cell number 0.00222397872751225 0.0189133233664503 0.927897078894874 0.578947368421053 18.5 18 5 irregular coat pigmentation 0.0673767767206636 0.24272227674533 0.927897078894874 0.578947368421053 18.5 18 5 abnormal nail morphology 0.0673767767206636 0.24272227674533 0.927897078894874 0.578947368421053 18.5 18 5 shiny skin 0.0673767767206636 0.24272227674533 0.927897078894874 0.578947368421053 18.5 18 5 thin dermal layer 0.0673767767206636 0.24272227674533 0.927897078894874 0.578947368421053 18.5 18 5 unresponsive to tactile stimuli 0.0673767767206636 0.24272227674533 0.927897078894874 0.578947368421053 18.5 18 5 abnormal metatarsal bone morphology 0.0673767767206636 0.24272227674533 0.927897078894874 0.578947368421053 18.5 18 5 decreased circulating magnesium level 0.0673767767206636 0.24272227674533 0.927897078894874 0.578947368421053 18.5 18 5 shortened RR interval 0.0673767767206636 0.24272227674533 0.927897078894874 0.578947368421053 18.5 18 5 postnatal lethality, complete penetrance 8.33691019453485e-15 9.01654961256758e-13 0.925930269259911 0.577720207253886 18.5 18 5 reduced female fertility 1.75307646822712e-09 7.78710306199098e-08 0.925715502690576 0.577586206896552 18.5 18 5 abnormal ovary morphology 0.000741035127158838 0.00766455251063455 0.925520901996296 0.577464788732394 18.5 18 5 increased susceptibility to injury 0.00372796966918032 0.0284457808346198 0.924652683514123 0.576923076923077 18.5 18 5 abnormal ureter morphology 0.0361046399056256 0.159929875986344 0.924652683514123 0.576923076923077 18.5 18 5 decreased circulating glycerol level 0.0361046399056256 0.159929875986344 0.924652683514123 0.576923076923077 18.5 18 5 hyperactivity 3.58664878313194e-14 3.43247929099503e-12 0.924486528494623 0.576819407008086 18.5 18 5 abnormal colon morphology 0.00213704967658385 0.0183941559532953 0.923607878222017 0.576271186440678 18.5 18 5 syndactyly 0.00213704967658385 0.0183941559532953 0.923607878222017 0.576271186440678 18.5 18 5 abnormal tooth development 0.0198502465178756 0.102442921604182 0.922784698294902 0.575757575757576 18.5 18 5 decreased brown adipose tissue amount 0.0198502465178756 0.102442921604182 0.922784698294902 0.575757575757576 18.5 18 5 dilated heart atrium 0.0198502465178756 0.102442921604182 0.922784698294902 0.575757575757576 18.5 18 5 abnormal seminiferous tubule morphology 2.16417856844348e-06 4.98462424907699e-05 0.922119388490796 0.575342465753425 18.5 18 5 neonatal lethality, complete penetrance 1.00371883257691e-16 1.34959491677571e-14 0.920867555569913 0.574561403508772 18.5 18 5 cleft secondary palate 0.000140723461934698 0.0018819871589385 0.92071799124385 0.574468085106383 18.5 18 5 abnormal chondrocyte morphology 0.00357451897083451 0.0273588182767718 0.920086497422695 0.574074074074074 18.5 18 5 diluted coat color 0.00357451897083451 0.0273588182767718 0.920086497422695 0.574074074074074 18.5 18 5 abnormal long bone morphology 0.00205068513126625 0.0177120807778639 0.919599936609674 0.573770491803279 18.5 18 5 abnormal male meiosis 0.00205068513126625 0.0177120807778639 0.919599936609674 0.573770491803279 18.5 18 5 abnormal gait 1.25318772240124e-11 8.20343278808705e-10 0.918069395799783 0.572815533980582 18.5 18 5 increased sensitivity to xenobiotic induced morbidity/mortality 4.64228674695123e-05 0.000695643872472361 0.917927936724929 0.572727272727273 18.5 18 5 azoospermia 1.14271500001827e-06 2.75971219664607e-05 0.91728647764965 0.572327044025157 18.5 18 5 female infertility 4.30083513097559e-10 2.05737065159649e-08 0.915846467480655 0.571428571428571 18.5 18 5 arrest of spermatogenesis 0.000381872618200666 0.00440840922677501 0.915846467480655 0.571428571428571 18.5 18 5 abnormal epidermis stratum corneum morphology 0.00599725852154861 0.0413245999234132 0.915846467480655 0.571428571428571 18.5 18 5 abnormal craniofacial development 0.00599725852154861 0.0413245999234132 0.915846467480655 0.571428571428571 18.5 18 5 abnormal cartilage morphology 0.010592551788255 0.0634915001765885 0.915846467480655 0.571428571428571 18.5 18 5 abnormal dermal layer morphology 0.018910255946853 0.100190120698183 0.915846467480655 0.571428571428571 18.5 18 5 small ears 0.0635835379326949 0.23089642424464 0.915846467480655 0.571428571428571 18.5 18 5 abnormal salivary gland morphology 0.0635835379326949 0.23089642424464 0.915846467480655 0.571428571428571 18.5 18 5 decreased cochlear outer hair cell number 0.0635835379326949 0.23089642424464 0.915846467480655 0.571428571428571 18.5 18 5 increased acute inflammation 0.0635835379326949 0.23089642424464 0.915846467480655 0.571428571428571 18.5 18 5 abnormal clavicle morphology 0.0635835379326949 0.23089642424464 0.915846467480655 0.571428571428571 18.5 18 5 abnormal tumor vascularization 0.0635835379326949 0.23089642424464 0.915846467480655 0.571428571428571 18.5 18 5 complete atrioventricular septal defect 0.0635835379326949 0.23089642424464 0.915846467480655 0.571428571428571 18.5 18 5 absent segment of posterior cerebral artery 0.0635835379326949 0.23089642424464 0.915846467480655 0.571428571428571 18.5 18 5 abnormal circulating cholesterol level 0.0342751910228444 0.15224917440951 0.915846467480655 0.571428571428571 18.5 18 5 abnormal jaw morphology 0.0342751910228444 0.15224917440951 0.915846467480655 0.571428571428571 18.5 18 5 abnormal respiration 0.0342751910228444 0.15224917440951 0.915846467480655 0.571428571428571 18.5 18 5 abnormal hormone level 0.0342751910228444 0.15224917440951 0.915846467480655 0.571428571428571 18.5 18 5 corneal vascularization 0.0342751910228444 0.15224917440951 0.915846467480655 0.571428571428571 18.5 18 5 prolonged QRS complex duration 0.0342751910228444 0.15224917440951 0.915846467480655 0.571428571428571 18.5 18 5 megacephaly 0.122816369742075 0.370085668968397 0.915846467480655 0.571428571428571 18.5 18 5 abnormal kidney blood vessel morphology 0.122816369742075 0.370085668968397 0.915846467480655 0.571428571428571 18.5 18 5 intestinal obstruction 0.122816369742075 0.370085668968397 0.915846467480655 0.571428571428571 18.5 18 5 abnormal squamosal bone morphology 0.122816369742075 0.370085668968397 0.915846467480655 0.571428571428571 18.5 18 5 decreased tongue size 0.122816369742075 0.370085668968397 0.915846467480655 0.571428571428571 18.5 18 5 sternebra fusion 0.122816369742075 0.370085668968397 0.915846467480655 0.571428571428571 18.5 18 5 abnormal renal reabsorbtion 0.122816369742075 0.370085668968397 0.915846467480655 0.571428571428571 18.5 18 5 increased stomach tumor incidence 0.122816369742075 0.370085668968397 0.915846467480655 0.571428571428571 18.5 18 5 infertility 7.3095747678408e-05 0.00103310041107977 0.913706639285607 0.570093457943925 18.5 18 5 hunched posture 0.000629898025671481 0.0065422602875065 0.912948219165843 0.569620253164557 18.5 18 5 abnormal response to infection 0.000629898025671481 0.0065422602875065 0.912948219165843 0.569620253164557 18.5 18 5 decreased anxiety-related response 2.41846653285347e-05 0.000391917622180652 0.912123514360815 0.569105691056911 18.5 18 5 abnormal spermiogenesis 0.00327320538725026 0.0253114213471642 0.911898853396687 0.568965517241379 18.5 18 5 abnormal cued conditioning behavior 0.00572780958969334 0.0395775732065616 0.911357024012613 0.568627450980392 18.5 18 5 abnormal gastrulation 0.00572780958969334 0.0395775732065616 0.911357024012613 0.568627450980392 18.5 18 5 abnormal response to novel object 0.00572780958969334 0.0395775732065616 0.911357024012613 0.568627450980392 18.5 18 5 cochlear inner hair cell degeneration 0.00572780958969334 0.0395775732065616 0.911357024012613 0.568627450980392 18.5 18 5 abnormal dendritic spine morphology 0.00572780958969334 0.0395775732065616 0.911357024012613 0.568627450980392 18.5 18 5 decreased birth weight 0.000204834710025856 0.00264689008410034 0.911026222914967 0.568421052631579 18.5 18 5 abnormal breathing pattern 0.0179845188219531 0.0955907918154024 0.909658315673353 0.567567567567568 18.5 18 5 abnormal hair follicle development 0.0179845188219531 0.0955907918154024 0.909658315673353 0.567567567567568 18.5 18 5 abnormal calcium ion homeostasis 0.0179845188219531 0.0955907918154024 0.909658315673353 0.567567567567568 18.5 18 5 decreased white adipose tissue amount 0.00179934271950729 0.0158718617545191 0.909011792350202 0.567164179104478 18.5 18 5 delayed eyelid opening 0.0324782250547368 0.149471942319441 0.908214413584983 0.566666666666667 18.5 18 5 abnormal microglial cell physiology 0.0324782250547368 0.149471942319441 0.908214413584983 0.566666666666667 18.5 18 5 increased spleen weight 6.44950489784437e-05 0.000931587831428608 0.907741631485251 0.566371681415929 18.5 18 5 postnatal lethality 1.46276754206324e-06 3.46536596274506e-05 0.907570746388962 0.566265060240964 18.5 18 5 increased leukocyte cell number 7.10324040415776e-06 0.000135917773118019 0.906372193679131 0.56551724137931 18.5 18 5 increased circulating triglyceride level 7.10324040415776e-06 0.000135917773118019 0.906372193679131 0.56551724137931 18.5 18 5 hyperkeratosis 0.00171920010461264 0.0153000192477121 0.905891614573257 0.565217391304348 18.5 18 5 increased lymphocyte cell number 0.00171920010461264 0.0153000192477121 0.905891614573257 0.565217391304348 18.5 18 5 abnormal forelimb morphology 0.00961561018725351 0.0578448133997415 0.905891614573257 0.565217391304348 18.5 18 5 abnormal lymphocyte physiology 0.00961561018725351 0.0578448133997415 0.905891614573257 0.565217391304348 18.5 18 5 fragile skeleton 0.059889853126814 0.219728627806711 0.905891614573257 0.565217391304348 18.5 18 5 abnormal carpal bone morphology 0.059889853126814 0.219728627806711 0.905891614573257 0.565217391304348 18.5 18 5 abnormal innervation pattern to muscle 0.059889853126814 0.219728627806711 0.905891614573257 0.565217391304348 18.5 18 5 blistering 0.059889853126814 0.219728627806711 0.905891614573257 0.565217391304348 18.5 18 5 abnormal Wolffian duct morphology 0.059889853126814 0.219728627806711 0.905891614573257 0.565217391304348 18.5 18 5 abnormal palatal shelf fusion at midline 0.059889853126814 0.219728627806711 0.905891614573257 0.565217391304348 18.5 18 5 cardiac fibrosis 0.00055231943320328 0.00592195944005672 0.905071803157353 0.564705882352941 18.5 18 5 abnormal response to injury 0.0170802126449935 0.0912718130062759 0.904104846102698 0.564102564102564 18.5 18 5 male infertility 2.65898045297203e-16 3.30710693838396e-14 0.901735512961818 0.562624254473161 18.5 18 5 abnormal osteoclast physiology 0.00284527543906803 0.0229792943333823 0.90153636642627 0.5625 18.5 18 5 decreased eosinophil cell number 0.00284527543906803 0.0229792943333823 0.90153636642627 0.5625 18.5 18 5 polydipsia 0.0307306000640548 0.142086185240402 0.90153636642627 0.5625 18.5 18 5 failure of primitive streak formation 0.0307306000640548 0.142086185240402 0.90153636642627 0.5625 18.5 18 5 abnormal long term potentiation 0.0307306000640548 0.142086185240402 0.90153636642627 0.5625 18.5 18 5 abnormal lumbar vertebrae morphology 0.0307306000640548 0.142086185240402 0.90153636642627 0.5625 18.5 18 5 increased fatty acid level 0.0307306000640548 0.142086185240402 0.90153636642627 0.5625 18.5 18 5 decreased mast cell number 0.11435049288556 0.347734536739401 0.90153636642627 0.5625 18.5 18 5 delayed hair appearance 0.11435049288556 0.347734536739401 0.90153636642627 0.5625 18.5 18 5 poor circulation 0.11435049288556 0.347734536739401 0.90153636642627 0.5625 18.5 18 5 abnormal olfaction 0.11435049288556 0.347734536739401 0.90153636642627 0.5625 18.5 18 5 paternal imprinting 0.11435049288556 0.347734536739401 0.90153636642627 0.5625 18.5 18 5 impaired muscle relaxation 0.11435049288556 0.347734536739401 0.90153636642627 0.5625 18.5 18 5 small pancreas 0.11435049288556 0.347734536739401 0.90153636642627 0.5625 18.5 18 5 abnormal amnion morphology 0.11435049288556 0.347734536739401 0.90153636642627 0.5625 18.5 18 5 sepsis 0.11435049288556 0.347734536739401 0.90153636642627 0.5625 18.5 18 5 blepharitis 0.11435049288556 0.347734536739401 0.90153636642627 0.5625 18.5 18 5 loose skin 0.11435049288556 0.347734536739401 0.90153636642627 0.5625 18.5 18 5 abnormal thoracic cage shape 0.11435049288556 0.347734536739401 0.90153636642627 0.5625 18.5 18 5 increased startle reflex 0.000504167283208889 0.00546455824393077 0.900410852860195 0.561797752808989 18.5 18 5 increased bone trabecula number 0.0162024000977195 0.0868609272480112 0.899093178441375 0.560975609756098 18.5 18 5 abnormal circulating protein level 0.00868945436781774 0.0530429883188874 0.897529538131042 0.56 18.5 18 5 mandible hypoplasia 0.0563350016245852 0.209137331306344 0.897529538131042 0.56 18.5 18 5 increased pre-B cell number 0.0563350016245852 0.209137331306344 0.897529538131042 0.56 18.5 18 5 diaphragmatic hernia 0.0563350016245852 0.209137331306344 0.897529538131042 0.56 18.5 18 5 decreased litter size 2.06076192016336e-09 9.07282349806434e-08 0.89547621686943 0.558718861209964 18.5 18 5 abnormal homeostasis 0.0153545414285959 0.0824043620358844 0.894547712422965 0.558139534883721 18.5 18 5 abnormal hair growth 0.00824934688077496 0.0516265641374548 0.893830927396985 0.557692307692308 18.5 18 5 increased double-negative T cell number 0.00448199280331003 0.0327924919927197 0.89332565270654 0.557377049180328 18.5 18 5 increased T cell number 0.00074994819054785 0.00774064781737667 0.89242993848257 0.556818181818182 18.5 18 5 impaired wound healing 0.027423058423953 0.128103019398278 0.890406287828415 0.555555555555556 18.5 18 5 short radius 0.027423058423953 0.128103019398278 0.890406287828415 0.555555555555556 18.5 18 5 underdeveloped hair follicles 0.106423787715298 0.327837983828858 0.890406287828415 0.555555555555556 18.5 18 5 cortical renal glomerulopathies 0.106423787715298 0.327837983828858 0.890406287828415 0.555555555555556 18.5 18 5 absent spleen 0.106423787715298 0.327837983828858 0.890406287828415 0.555555555555556 18.5 18 5 abnormal phrenic nerve morphology 0.106423787715298 0.327837983828858 0.890406287828415 0.555555555555556 18.5 18 5 blepharoptosis 0.106423787715298 0.327837983828858 0.890406287828415 0.555555555555556 18.5 18 5 abnormal iron level 0.106423787715298 0.327837983828858 0.890406287828415 0.555555555555556 18.5 18 5 decreased activity of thyroid 0.106423787715298 0.327837983828858 0.890406287828415 0.555555555555556 18.5 18 5 absent ureter 0.106423787715298 0.327837983828858 0.890406287828415 0.555555555555556 18.5 18 5 long tibia 0.106423787715298 0.327837983828858 0.890406287828415 0.555555555555556 18.5 18 5 abnormal eye anterior chamber morphology 0.106423787715298 0.327837983828858 0.890406287828415 0.555555555555556 18.5 18 5 decreased fluid intake 0.106423787715298 0.327837983828858 0.890406287828415 0.555555555555556 18.5 18 5 deformed nails 0.234441670254508 0.519531095552864 0.890406287828415 0.555555555555556 18.5 18 5 thick tail 0.234441670254508 0.519531095552864 0.890406287828415 0.555555555555556 18.5 18 5 absent parathyroid glands 0.234441670254508 0.519531095552864 0.890406287828415 0.555555555555556 18.5 18 5 abnormal sympathetic neuron morphology 0.234441670254508 0.519531095552864 0.890406287828415 0.555555555555556 18.5 18 5 psoriasis 0.234441670254508 0.519531095552864 0.890406287828415 0.555555555555556 18.5 18 5 wavy vibrissae 0.234441670254508 0.519531095552864 0.890406287828415 0.555555555555556 18.5 18 5 abnormal lens vesicle development 0.234441670254508 0.519531095552864 0.890406287828415 0.555555555555556 18.5 18 5 abnormal kindling response 0.234441670254508 0.519531095552864 0.890406287828415 0.555555555555556 18.5 18 5 multifocal hepatic necrosis 0.234441670254508 0.519531095552864 0.890406287828415 0.555555555555556 18.5 18 5 abnormal ion homeostasis 0.234441670254508 0.519531095552864 0.890406287828415 0.555555555555556 18.5 18 5 abnormal vomeronasal organ morphology 0.234441670254508 0.519531095552864 0.890406287828415 0.555555555555556 18.5 18 5 abnormal laryngeal cartilage morphology 0.234441670254508 0.519531095552864 0.890406287828415 0.555555555555556 18.5 18 5 abnormal thymus lobule morphology 0.234441670254508 0.519531095552864 0.890406287828415 0.555555555555556 18.5 18 5 abnormal gut-associated lymphoid tissue morphology 0.234441670254508 0.519531095552864 0.890406287828415 0.555555555555556 18.5 18 5 genetic imprinting 0.234441670254508 0.519531095552864 0.890406287828415 0.555555555555556 18.5 18 5 priapism 0.234441670254508 0.519531095552864 0.890406287828415 0.555555555555556 18.5 18 5 premature bone ossification 0.234441670254508 0.519531095552864 0.890406287828415 0.555555555555556 18.5 18 5 decreased cochlear hair cell number 0.234441670254508 0.519531095552864 0.890406287828415 0.555555555555556 18.5 18 5 abnormal posterior eye segment morphology 0.234441670254508 0.519531095552864 0.890406287828415 0.555555555555556 18.5 18 5 hemothorax 0.234441670254508 0.519531095552864 0.890406287828415 0.555555555555556 18.5 18 5 abnormal hyoid bone lesser horn morphology 0.234441670254508 0.519531095552864 0.890406287828415 0.555555555555556 18.5 18 5 abnormal incisor color 0.234441670254508 0.519531095552864 0.890406287828415 0.555555555555556 18.5 18 5 retropulsion 0.234441670254508 0.519531095552864 0.890406287828415 0.555555555555556 18.5 18 5 decreased airway resistance 0.234441670254508 0.519531095552864 0.890406287828415 0.555555555555556 18.5 18 5 abnormal oxidative phosphorylation 0.234441670254508 0.519531095552864 0.890406287828415 0.555555555555556 18.5 18 5 decreased bone trabecular spacing 0.234441670254508 0.519531095552864 0.890406287828415 0.555555555555556 18.5 18 5 increased myeloid cell number 0.234441670254508 0.519531095552864 0.890406287828415 0.555555555555556 18.5 18 5 abnormal coronary sinus connection 0.234441670254508 0.519531095552864 0.890406287828415 0.555555555555556 18.5 18 5 adipose tissue inflammation 0.234441670254508 0.519531095552864 0.890406287828415 0.555555555555556 18.5 18 5 polyphagia 0.00782569792557899 0.0510121811296059 0.890406287828415 0.555555555555556 18.5 18 5 impaired limb coordination 0.00782569792557899 0.0510121811296059 0.890406287828415 0.555555555555556 18.5 18 5 axon degeneration 0.00782569792557899 0.0510121811296059 0.890406287828415 0.555555555555556 18.5 18 5 decreased platelet aggregation 0.00782569792557899 0.0510121811296059 0.890406287828415 0.555555555555556 18.5 18 5 abnormal cartilage development 0.0145388800890494 0.0796014808982718 0.890406287828415 0.555555555555556 18.5 18 5 abnormal autopod morphology 0.0145388800890494 0.0796014808982718 0.890406287828415 0.555555555555556 18.5 18 5 albuminuria 0.0145388800890494 0.0796014808982718 0.890406287828415 0.555555555555556 18.5 18 5 decreased bone ossification 0.0529403972981517 0.208039870899135 0.890406287828415 0.555555555555556 18.5 18 5 abnormal skeleton development 0.0012880086278808 0.0119997058496386 0.890406287828414 0.555555555555556 18.5 18 5 increased body weight 1.92175244197372e-07 5.55855720861586e-06 0.887226265371884 0.553571428571429 18.5 18 5 decreased T cell number 1.02797151182669e-05 0.000188714327355638 0.88598190875846 0.552795031055901 18.5 18 5 increased total body fat amount 5.74199062029952e-05 0.00083527495134474 0.885090429393618 0.552238805970149 18.5 18 5 abnormal femur morphology 0.00383484750853202 0.0289066156893133 0.885090429393618 0.552238805970149 18.5 18 5 dermatitis 0.00702926252288373 0.0469403772501296 0.884265554808908 0.551724137931034 18.5 18 5 thrombocytosis 0.00702926252288373 0.0469403772501296 0.884265554808908 0.551724137931034 18.5 18 5 abnormal middle ear morphology 0.0497162346085417 0.195833940758112 0.884265554808908 0.551724137931034 18.5 18 5 abnormal spinal nerve morphology 0.0497162346085417 0.195833940758112 0.884265554808908 0.551724137931034 18.5 18 5 increased double-positive T cell number 0.0497162346085417 0.195833940758112 0.884265554808908 0.551724137931034 18.5 18 5 increased T cell proliferation 0.000325876360043721 0.00393503614373182 0.883749044554931 0.551401869158878 18.5 18 5 organ of Corti degeneration 0.0130087242163565 0.0752539569492718 0.883137665070632 0.551020408163265 18.5 18 5 decreased urine osmolality 0.0130087242163565 0.0752539569492718 0.883137665070632 0.551020408163265 18.5 18 5 increased fluid intake 0.0130087242163565 0.0752539569492718 0.883137665070632 0.551020408163265 18.5 18 5 abnormal physiological neovascularization 0.0990417791053927 0.308923417585786 0.88150222495013 0.55 18.5 18 5 abnormal heart right ventricle morphology 0.0990417791053927 0.308923417585786 0.88150222495013 0.55 18.5 18 5 decreased circulating VLDL cholesterol level 0.0990417791053927 0.308923417585786 0.88150222495013 0.55 18.5 18 5 abnormal response to tactile stimuli 0.0990417791053927 0.308923417585786 0.88150222495013 0.55 18.5 18 5 abnormal induced retinal neovascularization 0.0990417791053927 0.308923417585786 0.88150222495013 0.55 18.5 18 5 abnormal heart electrocardiography waveform feature 0.0990417791053927 0.308923417585786 0.88150222495013 0.55 18.5 18 5 decreased muscle cell glucose uptake 0.0990417791053927 0.308923417585786 0.88150222495013 0.55 18.5 18 5 increased thermal nociceptive threshold 0.000997938946612879 0.00975642805953988 0.880621603346784 0.549450549450549 18.5 18 5 abnormal gluconeogenesis 0.0122949349672736 0.0724731059978507 0.879930919736316 0.549019607843137 18.5 18 5 abnormal cranial ganglia morphology 0.046665591236579 0.184694762451854 0.87891717443708 0.548387096774194 18.5 18 5 increased food intake 0.00170796706202411 0.0152551815683482 0.877686198002294 0.547619047619048 18.5 18 5 abnormal muscle morphology 0.0229932691039134 0.112038701069509 0.877686198002294 0.547619047619048 18.5 18 5 decreased neutrophil cell number 0.000252400417698616 0.00312361213445426 0.876707729554131 0.547008547008547 18.5 18 5 reduced male fertility 5.05019468748012e-07 1.30857909219862e-05 0.875500808120274 0.54625550660793 18.5 18 5 increased circulating calcium level 0.0109684826933274 0.0655867805280092 0.874217082595171 0.545454545454545 18.5 18 5 abnormal T-helper 2 physiology 0.0109684826933274 0.0655867805280092 0.874217082595171 0.545454545454545 18.5 18 5 osteoporosis 0.0216614123720345 0.10773445741568 0.874217082595171 0.545454545454545 18.5 18 5 intestinal inflammation 0.0921863936405465 0.289720346406645 0.874217082595171 0.545454545454545 18.5 18 5 abnormal tracheal cartilage morphology 0.0921863936405465 0.289720346406645 0.874217082595171 0.545454545454545 18.5 18 5 parakeratosis 0.0921863936405465 0.289720346406645 0.874217082595171 0.545454545454545 18.5 18 5 abnormal circulating lipid level 0.0921863936405465 0.289720346406645 0.874217082595171 0.545454545454545 18.5 18 5 abnormal cerebral cortex pyramidal cell morphology 0.0921863936405465 0.289720346406645 0.874217082595171 0.545454545454545 18.5 18 5 decreased atrioventricular cushion size 0.21280261805563 0.481661976718271 0.874217082595171 0.545454545454545 18.5 18 5 abnormal large intestine morphology 0.21280261805563 0.481661976718271 0.874217082595171 0.545454545454545 18.5 18 5 abnormal sebaceous gland morphology 0.21280261805563 0.481661976718271 0.874217082595171 0.545454545454545 18.5 18 5 abnormal food preference 0.21280261805563 0.481661976718271 0.874217082595171 0.545454545454545 18.5 18 5 abnormal hemoglobin 0.21280261805563 0.481661976718271 0.874217082595171 0.545454545454545 18.5 18 5 abnormal fear/anxiety-related behavior 0.21280261805563 0.481661976718271 0.874217082595171 0.545454545454545 18.5 18 5 abnormal primary sex determination 0.21280261805563 0.481661976718271 0.874217082595171 0.545454545454545 18.5 18 5 retinal detachment 0.21280261805563 0.481661976718271 0.874217082595171 0.545454545454545 18.5 18 5 fused joints 0.21280261805563 0.481661976718271 0.874217082595171 0.545454545454545 18.5 18 5 abnormal frequency of paradoxical sleep 0.21280261805563 0.481661976718271 0.874217082595171 0.545454545454545 18.5 18 5 pulmonary hypertension 0.21280261805563 0.481661976718271 0.874217082595171 0.545454545454545 18.5 18 5 abnormal pituitary gland development 0.21280261805563 0.481661976718271 0.874217082595171 0.545454545454545 18.5 18 5 abnormal coronal suture morphology 0.21280261805563 0.481661976718271 0.874217082595171 0.545454545454545 18.5 18 5 abnormal crista ampullaris neuroepithelium morphology 0.21280261805563 0.481661976718271 0.874217082595171 0.545454545454545 18.5 18 5 increased motor neuron number 0.21280261805563 0.481661976718271 0.874217082595171 0.545454545454545 18.5 18 5 increased circulating triiodothyronine level 0.21280261805563 0.481661976718271 0.874217082595171 0.545454545454545 18.5 18 5 abnormal superovulation 0.21280261805563 0.481661976718271 0.874217082595171 0.545454545454545 18.5 18 5 decreased palatine bone horizontal plate size 0.21280261805563 0.481661976718271 0.874217082595171 0.545454545454545 18.5 18 5 abnormal extraembryonic ectoderm morphology 0.21280261805563 0.481661976718271 0.874217082595171 0.545454545454545 18.5 18 5 increased subcutaneous adipose tissue amount 0.21280261805563 0.481661976718271 0.874217082595171 0.545454545454545 18.5 18 5 abnormal motor capabilities/coordination/movement 0.000121253551672378 0.00165270251937008 0.874217082595171 0.545454545454545 18.5 18 5 abnormal skin morphology 0.00563884870534651 0.0392353458868516 0.874217082595171 0.545454545454545 18.5 18 5 abnormal tail morphology 0.00563884870534651 0.0392353458868516 0.874217082595171 0.545454545454545 18.5 18 5 belly spot 0.0437870243194698 0.178663369062033 0.874217082595171 0.545454545454545 18.5 18 5 abnormal skeleton physiology 0.0437870243194698 0.178663369062033 0.874217082595171 0.545454545454545 18.5 18 5 abnormal locomotor coordination 0.0437870243194698 0.178663369062033 0.874217082595171 0.545454545454545 18.5 18 5 cardiovascular system phenotype 0.0437870243194698 0.178663369062033 0.874217082595171 0.545454545454545 18.5 18 5 increased circulating insulin level 2.9727648477842e-05 0.000468398997472145 0.871485154212061 0.54375 18.5 18 5 abnormal lipid level 0.00248332363667031 0.0209044587012433 0.86895071462773 0.542168674698795 18.5 18 5 abnormal intestinal epithelium morphology 0.0192066560780989 0.101436426739429 0.868146130632704 0.541666666666667 18.5 18 5 abnormal osteoclast morphology 0.0192066560780989 0.101436426739429 0.868146130632704 0.541666666666667 18.5 18 5 abnormal phalanx morphology 0.0192066560780989 0.101436426739429 0.868146130632704 0.541666666666667 18.5 18 5 increased stereotypic behavior 0.085829038785338 0.271110773306068 0.868146130632704 0.541666666666667 18.5 18 5 abnormal primitive streak formation 0.085829038785338 0.271110773306068 0.868146130632704 0.541666666666667 18.5 18 5 abnormal impulse conducting system conduction 0.085829038785338 0.271110773306068 0.868146130632704 0.541666666666667 18.5 18 5 abnormal tumor morphology 0.085829038785338 0.271110773306068 0.868146130632704 0.541666666666667 18.5 18 5 decreased fatty acid level 0.085829038785338 0.271110773306068 0.868146130632704 0.541666666666667 18.5 18 5 increased circulating total protein level 0.085829038785338 0.271110773306068 0.868146130632704 0.541666666666667 18.5 18 5 increased osteoclast cell number 0.00921961915815872 0.0560075162750144 0.867051368803407 0.540983606557377 18.5 18 5 small seminiferous tubules 0.00449972529566701 0.0327924919927197 0.866341253022241 0.540540540540541 18.5 18 5 decreased width of hypertrophic chondrocyte zone 0.0385272226615998 0.169622064372973 0.866341253022241 0.540540540540541 18.5 18 5 increased circulating chloride level 0.0180791714298586 0.0959913317647244 0.865474911769219 0.54 18.5 18 5 absent gastric milk in neonates 0.00401412240849994 0.0302121921063346 0.863009171279848 0.538461538461538 18.5 18 5 absent corpus luteum 0.0170147877348552 0.0910199666461338 0.863009171279848 0.538461538461538 18.5 18 5 abnormal female meiosis 0.0170147877348552 0.0910199666461338 0.863009171279848 0.538461538461538 18.5 18 5 decreased B-1 B cell number 0.0361329006248545 0.159929875986344 0.863009171279848 0.538461538461538 18.5 18 5 abnormal nerve conduction 0.0799370902967048 0.262897574327077 0.863009171279848 0.538461538461538 18.5 18 5 abnormal membranous labyrinth morphology 0.194029534409503 0.445061357020523 0.863009171279848 0.538461538461538 18.5 18 5 lymphoid hypoplasia 0.194029534409503 0.445061357020523 0.863009171279848 0.538461538461538 18.5 18 5 abnormal lung interstitium morphology 0.194029534409503 0.445061357020523 0.863009171279848 0.538461538461538 18.5 18 5 increased synaptic depression 0.194029534409503 0.445061357020523 0.863009171279848 0.538461538461538 18.5 18 5 abnormal bile duct development 0.194029534409503 0.445061357020523 0.863009171279848 0.538461538461538 18.5 18 5 abnormal afterhyperpolarization 0.194029534409503 0.445061357020523 0.863009171279848 0.538461538461538 18.5 18 5 vestibular hair cell degeneration 0.194029534409503 0.445061357020523 0.863009171279848 0.538461538461538 18.5 18 5 increased circulating ammonia level 0.194029534409503 0.445061357020523 0.863009171279848 0.538461538461538 18.5 18 5 small pituitary gland 0.194029534409503 0.445061357020523 0.863009171279848 0.538461538461538 18.5 18 5 orthokeratosis 0.194029534409503 0.445061357020523 0.863009171279848 0.538461538461538 18.5 18 5 increased prostaglandin level 0.194029534409503 0.445061357020523 0.863009171279848 0.538461538461538 18.5 18 5 increased B cell number 0.000496459682469242 0.00544008028297849 0.863009171279848 0.538461538461538 18.5 18 5 abnormal B cell differentiation 0.00198558350664768 0.017209543459185 0.863009171279848 0.538461538461538 18.5 18 5 abnormal social investigation 0.00379033230254424 0.0287323175935903 0.861468083473991 0.5375 18.5 18 5 scaly skin 0.0338856935604359 0.15224917440951 0.860002170683054 0.536585365853659 18.5 18 5 increased tumor growth/size 0.0338856935604359 0.15224917440951 0.860002170683054 0.536585365853659 18.5 18 5 short humerus 0.0338856935604359 0.15224917440951 0.860002170683054 0.536585365853659 18.5 18 5 improved glucose tolerance 1.14153242457213e-05 0.000202104050257877 0.858606063263114 0.535714285714286 18.5 18 5 reduced long term potentiation 0.000791741449860946 0.00809503888293607 0.858606063263114 0.535714285714286 18.5 18 5 abnormal neuron differentiation 0.000791741449860946 0.00809503888293607 0.858606063263114 0.535714285714286 18.5 18 5 decreased circulating progesterone level 0.07447717376966 0.257279635540005 0.858606063263114 0.535714285714286 18.5 18 5 increased triglyceride level 0.07447717376966 0.257279635540005 0.858606063263114 0.535714285714286 18.5 18 5 abnormal motor coordination/ balance 0.00158337806792512 0.0144537722714265 0.858027877361927 0.535353535353535 18.5 18 5 abnormal axon guidance 0.0317778059305284 0.146519540782557 0.857274891072008 0.534883720930233 18.5 18 5 cochlear ganglion degeneration 0.0141721270883014 0.0795694131031198 0.85663225622113 0.53448275862069 18.5 18 5 emphysema 0.0694168169557472 0.249709807921072 0.854790036315278 0.533333333333333 18.5 18 5 decreased salivation 0.177531432916512 0.411757053034802 0.854790036315278 0.533333333333333 18.5 18 5 abnormal prostate gland morphology 0.177531432916512 0.411757053034802 0.854790036315278 0.533333333333333 18.5 18 5 abnormal pup retrieval 0.177531432916512 0.411757053034802 0.854790036315278 0.533333333333333 18.5 18 5 no suckling reflex 0.177531432916512 0.411757053034802 0.854790036315278 0.533333333333333 18.5 18 5 abnormal seizure response to electrical stimulation 0.177531432916512 0.411757053034802 0.854790036315278 0.533333333333333 18.5 18 5 abnormal apical ectodermal ridge morphology 0.177531432916512 0.411757053034802 0.854790036315278 0.533333333333333 18.5 18 5 absent egg cylinders 0.177531432916512 0.411757053034802 0.854790036315278 0.533333333333333 18.5 18 5 abnormal lymph node B cell domain morphology 0.177531432916512 0.411757053034802 0.854790036315278 0.533333333333333 18.5 18 5 greasy coat 0.177531432916512 0.411757053034802 0.854790036315278 0.533333333333333 18.5 18 5 abnormal ear development 0.177531432916512 0.411757053034802 0.854790036315278 0.533333333333333 18.5 18 5 abnormal olfactory nerve morphology 0.177531432916512 0.411757053034802 0.854790036315278 0.533333333333333 18.5 18 5 abnormal secondary palate development 0.177531432916512 0.411757053034802 0.854790036315278 0.533333333333333 18.5 18 5 altered response to myocardial infarction 0.0298014492668745 0.138562813180094 0.854790036315278 0.533333333333333 18.5 18 5 irregular heartbeat 0.0298014492668745 0.138562813180094 0.854790036315278 0.533333333333333 18.5 18 5 increased circulating corticosterone level 0.0298014492668745 0.138562813180094 0.854790036315278 0.533333333333333 18.5 18 5 abnormal cell migration 0.0298014492668745 0.138562813180094 0.854790036315278 0.533333333333333 18.5 18 5 decreased IgG level 0.00112363383301533 0.0108545210082549 0.851902232138537 0.531531531531532 18.5 18 5 abnormal auditory brainstem response waveform shape 0.0647252478987727 0.234870976146166 0.851451012735921 0.53125 18.5 18 5 impaired swimming 0.0110955349784416 0.0662668505615208 0.849933274745305 0.53030303030303 18.5 18 5 abnormal retinal photoreceptor morphology 0.0603737366084051 0.221014966612815 0.848504815460019 0.529411764705882 18.5 18 5 abnormal endoderm development 0.0603737366084051 0.221014966612815 0.848504815460019 0.529411764705882 18.5 18 5 abnormal vision 0.0603737366084051 0.221014966612815 0.848504815460019 0.529411764705882 18.5 18 5 abnormal bone marrow cavity morphology 0.162893310205554 0.381361985069474 0.848504815460019 0.529411764705882 18.5 18 5 abnormal urinary bladder morphology 0.162893310205554 0.381361985069474 0.848504815460019 0.529411764705882 18.5 18 5 increased regulatory T cell number 0.162893310205554 0.381361985069474 0.848504815460019 0.529411764705882 18.5 18 5 abnormal tarsal bone morphology 0.162893310205554 0.381361985069474 0.848504815460019 0.529411764705882 18.5 18 5 abnormal tendon morphology 0.162893310205554 0.381361985069474 0.848504815460019 0.529411764705882 18.5 18 5 abnormal circulating chemokine level 0.162893310205554 0.381361985069474 0.848504815460019 0.529411764705882 18.5 18 5 common atrium 0.162893310205554 0.381361985069474 0.848504815460019 0.529411764705882 18.5 18 5 abnormal survival 0.162893310205554 0.381361985069474 0.848504815460019 0.529411764705882 18.5 18 5 decreased B cell number 1.62111059132042e-05 0.000281011330725403 0.848047153747257 0.529126213592233 18.5 18 5 reduced long term depression 0.0563356913617463 0.209137331306344 0.845885973436994 0.527777777777778 18.5 18 5 abnormal locomotor activation 0.00379241353754444 0.0287323175935903 0.845396739212912 0.527472527472527 18.5 18 5 abnormal learning/memory/conditioning 0.0216347389552649 0.10773445741568 0.845076513175332 0.527272727272727 18.5 18 5 abnormal cardiovascular system physiology 0.000595253582283709 0.0062757412619223 0.84354279899534 0.526315789473684 18.5 18 5 delayed sexual maturation 0.149809355487114 0.379660891894382 0.84354279899534 0.526315789473684 18.5 18 5 decreased tumor incidence 0.149809355487114 0.379660891894382 0.84354279899534 0.526315789473684 18.5 18 5 abnormal ear morphology 0.149809355487114 0.379660891894382 0.84354279899534 0.526315789473684 18.5 18 5 maternal imprinting 0.149809355487114 0.379660891894382 0.84354279899534 0.526315789473684 18.5 18 5 oliguria 0.149809355487114 0.379660891894382 0.84354279899534 0.526315789473684 18.5 18 5 eyelids fail to open 0.149809355487114 0.379660891894382 0.84354279899534 0.526315789473684 18.5 18 5 decreased liver glycogen level 0.149809355487114 0.379660891894382 0.84354279899534 0.526315789473684 18.5 18 5 thin interventricular septum 0.149809355487114 0.379660891894382 0.84354279899534 0.526315789473684 18.5 18 5 decreased IgM level 0.00317030631068527 0.0249488881648339 0.842673167243798 0.525773195876289 18.5 18 5 decreased circulating phosphate level 0.0491040519242632 0.194037059827807 0.841433941997852 0.525 18.5 18 5 abnormal skin pigmentation 0.0491040519242632 0.194037059827807 0.841433941997852 0.525 18.5 18 5 abnormal excitatory postsynaptic potential 0.00679709722201023 0.0455735292176562 0.840456666803894 0.524390243902439 18.5 18 5 abnormal associative learning 0.138045844395361 0.379660891894382 0.839525928523934 0.523809523809524 18.5 18 5 decreased vocalization 0.138045844395361 0.379660891894382 0.839525928523934 0.523809523809524 18.5 18 5 abnormal dendritic cell physiology 0.00235134262862313 0.0198944380568028 0.838812652458918 0.523364485981308 18.5 18 5 cochlear hair cell degeneration 0.0428576655422121 0.178663369062033 0.837791370820372 0.522727272727273 18.5 18 5 decreased compact bone thickness 0.0147724131017499 0.0804958983364795 0.83724770348045 0.522388059701492 18.5 18 5 increased bone mineral density 0.00196533812508315 0.017063799602598 0.836824316525466 0.52212389380531 18.5 18 5 failure of embryo implantation 0.127418983291891 0.379660891894382 0.836207644221468 0.521739130434783 18.5 18 5 pancreas inflammation 0.127418983291891 0.379660891894382 0.836207644221468 0.521739130434783 18.5 18 5 abnormal cochlear ganglion morphology 0.127418983291891 0.379660891894382 0.836207644221468 0.521739130434783 18.5 18 5 abnormal cardiovascular development 0.127418983291891 0.379660891894382 0.836207644221468 0.521739130434783 18.5 18 5 decreased epididymis weight 0.127418983291891 0.379660891894382 0.836207644221468 0.521739130434783 18.5 18 5 abnormal lens development 0.127418983291891 0.379660891894382 0.836207644221468 0.521739130434783 18.5 18 5 abnormal basicranium morphology 0.127418983291891 0.379660891894382 0.836207644221468 0.521739130434783 18.5 18 5 abnormal vertebral artery topology 0.127418983291891 0.379660891894382 0.836207644221468 0.521739130434783 18.5 18 5 cardiac hypertrophy 0.00416951610417652 0.0313343544082752 0.834074461455597 0.520408163265306 18.5 18 5 decreased T cell proliferation 0.00051762347471813 0.0055982104059189 0.833853456033907 0.52027027027027 18.5 18 5 abnormal thyroid gland morphology 0.117780912376154 0.357074978105647 0.833420285407396 0.52 18.5 18 5 abnormal egg cylinder morphology 0.117780912376154 0.357074978105647 0.833420285407396 0.52 18.5 18 5 decreased placenta weight 0.117780912376154 0.357074978105647 0.833420285407396 0.52 18.5 18 5 abnormal cytokine secretion 0.000433747231862707 0.00493796905839123 0.832587697709686 0.519480519480519 18.5 18 5 decreased tumor growth/size 0.0306567041305304 0.142086185240402 0.831045868639854 0.518518518518518 18.5 18 5 wrinkled skin 0.109010451987454 0.33518355910852 0.831045868639854 0.518518518518518 18.5 18 5 decreased susceptibility to pharmacologically induced seizures 0.109010451987454 0.33518355910852 0.831045868639854 0.518518518518518 18.5 18 5 thick interventricular septum 0.109010451987454 0.33518355910852 0.831045868639854 0.518518518518518 18.5 18 5 short mandible 0.0286920855606746 0.133905371167313 0.829985861154343 0.517857142857143 18.5 18 5 abnormal enzyme/coenzyme level 0.0268596218324394 0.125707073016355 0.828998957633352 0.517241379310345 18.5 18 5 abnormal parietal bone morphology 0.101006751442287 0.313284656125547 0.828998957633352 0.517241379310345 18.5 18 5 decreased granulocyte number 0.101006751442287 0.313284656125547 0.828998957633352 0.517241379310345 18.5 18 5 focal hair loss 0.101006751442287 0.313284656125547 0.828998957633352 0.517241379310345 18.5 18 5 absent long term depression 0.101006751442287 0.313284656125547 0.828998957633352 0.517241379310345 18.5 18 5 increased susceptibility to induced arthritis 0.101006751442287 0.313284656125547 0.828998957633352 0.517241379310345 18.5 18 5 abnormal CD8-positive, alpha beta T cell morphology 0.0936847910561931 0.293872531843985 0.827216164176075 0.516129032258065 18.5 18 5 decreased double-negative T cell number 0.0936847910561931 0.293872531843985 0.827216164176075 0.516129032258065 18.5 18 5 decreased susceptibility to bacterial infection induced morbidity/mortality 0.0936847910561931 0.293872531843985 0.827216164176075 0.516129032258065 18.5 18 5 abnormal action potential 0.0181561015905482 0.0962970206961379 0.82426182073259 0.514285714285714 18.5 18 5 abnormal pancreatic beta cell physiology 0.075133519434123 0.257279635540005 0.823024190371129 0.513513513513513 18.5 18 5 increased vascular permeability 0.0699063339874227 0.251107589593811 0.821913496456998 0.512820512820513 18.5 18 5 abnormal circulating hormone level 0.0699063339874227 0.251107589593811 0.821913496456998 0.512820512820513 18.5 18 5 abnormal cholesterol homeostasis 0.0650833282062818 0.235826334906229 0.820911162924733 0.51219512195122 18.5 18 5 lethality at weaning, incomplete penetrance 0.0650833282062818 0.235826334906229 0.820911162924733 0.51219512195122 18.5 18 5 impaired macrophage phagocytosis 0.0606278461628878 0.221619055591746 0.820002069721051 0.511627906976744 18.5 18 5 abnormal blood circulation 0.0606278461628878 0.221619055591746 0.820002069721051 0.511627906976744 18.5 18 5 abnormal suckling behavior 0.0102055500580186 0.0612456110236941 0.819578514932973 0.511363636363636 18.5 18 5 increased liver weight 0.0102055500580186 0.0612456110236941 0.819578514932973 0.511363636363636 18.5 18 5 abnormal innervation 0.0526928154037207 0.207230637654949 0.818415992216756 0.51063829787234 18.5 18 5 abnormal long bone hypertrophic chondrocyte zone 0.049158287934185 0.194097208311564 0.817720060250585 0.510204081632653 18.5 18 5 increased B cell proliferation 0.034944829314021 0.15508521484144 0.814948127842956 0.508474576271186 18.5 18 5 abnormal maternal nurturing 0.0326725108962508 0.150227118030358 0.81450280099714 0.508196721311475 18.5 18 5 lung inflammation 0.00229222156257263 0.0194604134365168 0.813150448149184 0.507352941176471 18.5 18 5 abnormal epidermal layer morphology 0.0250378647857543 0.119135321237149 0.812979654104205 0.507246376811594 18.5 18 5 atelectasis 0.0234409151886157 0.113996630560472 0.812652499313821 0.507042253521127 18.5 18 5 abnormal CD4-positive, alpha-beta T cell physiology 0.0234409151886157 0.113996630560472 0.812652499313821 0.507042253521127 18.5 18 5 increased anxiety-related response 0.00272820308282979 0.0225088065291513 0.807130879614246 0.503597122302158 18.5 18 5 teratozoospermia 0.0176701455166897 0.0942218370262929 0.801365659045573 0.5 18.5 18 5 abnormal long bone epiphyseal plate morphology 0.0447398637971389 0.178663369062033 0.801365659045573 0.5 18.5 18 5 abnormal eye physiology 0.0447398637971389 0.178663369062033 0.801365659045573 0.5 18.5 18 5 abnormal circadian rhythm 0.0783980267835631 0.262897574327077 0.801365659045573 0.5 18.5 18 5 abnormal photoreceptor outer segment morphology 0.0783980267835631 0.262897574327077 0.801365659045573 0.5 18.5 18 5 lethality, incomplete penetrance 0.0783980267835631 0.262897574327077 0.801365659045573 0.5 18.5 18 5 salivary gland inflammation 0.132596685928827 0.379660891894382 0.801365659045573 0.5 18.5 18 5 abnormal estrous cycle 0.132596685928827 0.379660891894382 0.801365659045573 0.5 18.5 18 5 abnormal pain threshold 0.132596685928827 0.379660891894382 0.801365659045573 0.5 18.5 18 5 abnormal spleen marginal zone morphology 0.132596685928827 0.379660891894382 0.801365659045573 0.5 18.5 18 5 enhanced paired-pulse facilitation 0.132596685928827 0.379660891894382 0.801365659045573 0.5 18.5 18 5 abnormal oogenesis 0.183905295150174 0.424560948200518 0.801365659045573 0.5 18.5 18 5 abnormal female reproductive system physiology 0.183905295150174 0.424560948200518 0.801365659045573 0.5 18.5 18 5 abnormal retinal layer morphology 0.183905295150174 0.424560948200518 0.801365659045573 0.5 18.5 18 5 abnormal limb posture 0.183905295150174 0.424560948200518 0.801365659045573 0.5 18.5 18 5 abnormal mesenteric lymph node morphology 0.183905295150174 0.424560948200518 0.801365659045573 0.5 18.5 18 5 abnormal sperm midpiece morphology 0.183905295150174 0.424560948200518 0.801365659045573 0.5 18.5 18 5 failure of palatal shelf elevation 0.183905295150174 0.424560948200518 0.801365659045573 0.5 18.5 18 5 pulmonary vascular congestion 0.183905295150174 0.424560948200518 0.801365659045573 0.5 18.5 18 5 abnormal stomach glandular epithelium morphology 0.219362832695811 0.49292235440906 0.801365659045573 0.5 18.5 18 5 thick dermal layer 0.219362832695811 0.49292235440906 0.801365659045573 0.5 18.5 18 5 eye inflammation 0.219362832695811 0.49292235440906 0.801365659045573 0.5 18.5 18 5 abnormal thymus medulla morphology 0.219362832695811 0.49292235440906 0.801365659045573 0.5 18.5 18 5 abnormal Peyer's patch follicle morphology 0.219362832695811 0.49292235440906 0.801365659045573 0.5 18.5 18 5 abnormal white adipose tissue morphology 0.219362832695811 0.49292235440906 0.801365659045573 0.5 18.5 18 5 absent allantois 0.219362832695811 0.49292235440906 0.801365659045573 0.5 18.5 18 5 increased circulating glycerol level 0.219362832695811 0.49292235440906 0.801365659045573 0.5 18.5 18 5 abnormal anterior eye segment morphology 0.219362832695811 0.49292235440906 0.801365659045573 0.5 18.5 18 5 abnormal macrophage chemotaxis 0.219362832695811 0.49292235440906 0.801365659045573 0.5 18.5 18 5 primary atelectasis 0.219362832695811 0.49292235440906 0.801365659045573 0.5 18.5 18 5 abnormal aerobic respiration 0.219362832695811 0.49292235440906 0.801365659045573 0.5 18.5 18 5 impaired leukocyte tethering or rolling 0.219362832695811 0.49292235440906 0.801365659045573 0.5 18.5 18 5 decreased exploration in new environment 0.0201217453598454 0.103736459238581 0.801365659045573 0.5 18.5 18 5 abnormal seminal vesicle morphology 0.0513335467676039 0.202044616431036 0.801365659045573 0.5 18.5 18 5 abnormal brain wave pattern 0.0589970708367964 0.217415131417083 0.801365659045573 0.5 18.5 18 5 kidney inflammation 0.0632918994281093 0.23089642424464 0.801365659045573 0.5 18.5 18 5 abnormal lymph node morphology 0.0679341153729169 0.24455298406676 0.801365659045573 0.5 18.5 18 5 abnormal sleep pattern 0.0729570246691296 0.257279635540005 0.801365659045573 0.5 18.5 18 5 delayed wound healing 0.0729570246691296 0.257279635540005 0.801365659045573 0.5 18.5 18 5 abnormal spleen white pulp morphology 0.0842992959499524 0.267297002773112 0.801365659045573 0.5 18.5 18 5 abnormal cytotoxic T cell physiology 0.0842992959499524 0.267297002773112 0.801365659045573 0.5 18.5 18 5 abnormal female reproductive system morphology 0.0907086160505825 0.28616066255653 0.801365659045573 0.5 18.5 18 5 decreased pancreatic beta cell number 0.113570484295159 0.347734536739401 0.801365659045573 0.5 18.5 18 5 increased susceptibility to weight gain 0.113570484295159 0.347734536739401 0.801365659045573 0.5 18.5 18 5 abnormal skin physiology 0.113570484295159 0.347734536739401 0.801365659045573 0.5 18.5 18 5 increased susceptibility to viral infection induced morbidity/mortality 0.113570484295159 0.347734536739401 0.801365659045573 0.5 18.5 18 5 abnormal leukocyte cell number 0.155624734455604 0.379660891894382 0.801365659045573 0.5 18.5 18 5 myoclonus 0.143543730205248 0.379660891894382 0.801365659045573 0.5 18.5 18 5 abnormal stomach morphology 0.155624734455604 0.379660891894382 0.801365659045573 0.5 18.5 18 5 abnormal kidney cortex morphology 0.155624734455604 0.379660891894382 0.801365659045573 0.5 18.5 18 5 reddish skin 0.143543730205248 0.379660891894382 0.801365659045573 0.5 18.5 18 5 abnormal spleen germinal center morphology 0.143543730205248 0.379660891894382 0.801365659045573 0.5 18.5 18 5 abnormal ocular fundus morphology 0.155624734455604 0.379660891894382 0.801365659045573 0.5 18.5 18 5 increased bone resorption 0.143543730205248 0.379660891894382 0.801365659045573 0.5 18.5 18 5 abnormal foregut morphology 0.169008927798444 0.394565657342683 0.801365659045573 0.5 18.5 18 5 apnea 0.169008927798444 0.394565657342683 0.801365659045573 0.5 18.5 18 5 abnormal cardiac muscle contractility 0.169008927798444 0.394565657342683 0.801365659045573 0.5 18.5 18 5 hypopigmentation 0.169008927798444 0.394565657342683 0.801365659045573 0.5 18.5 18 5 waved hair 0.200576931868834 0.458790913125265 0.801365659045573 0.5 18.5 18 5 abnormal dopamine level 0.200576931868834 0.458790913125265 0.801365659045573 0.5 18.5 18 5 abnormal trachea morphology 0.200576931868834 0.458790913125265 0.801365659045573 0.5 18.5 18 5 disorganized retinal layers 0.240712372947465 0.528717022257677 0.801365659045573 0.5 18.5 18 5 reduced male mating frequency 0.240712372947465 0.528717022257677 0.801365659045573 0.5 18.5 18 5 abnormal meiosis 0.240712372947465 0.528717022257677 0.801365659045573 0.5 18.5 18 5 white spotting 0.240712372947465 0.528717022257677 0.801365659045573 0.5 18.5 18 5 abnormal pulmonary elastic fiber morphology 0.240712372947465 0.528717022257677 0.801365659045573 0.5 18.5 18 5 abnormal molar crown morphology 0.240712372947465 0.528717022257677 0.801365659045573 0.5 18.5 18 5 decreased skeletal muscle weight 0.240712372947465 0.528717022257677 0.801365659045573 0.5 18.5 18 5 dilated respiratory conducting tubes 0.240712372947465 0.528717022257677 0.801365659045573 0.5 18.5 18 5 embryonic lethality between somite formation and embryo turning, incomplete penetrance 0.240712372947465 0.528717022257677 0.801365659045573 0.5 18.5 18 5 abnormal pinna reflex 0.265242699076931 0.563683224223721 0.801365659045573 0.5 18.5 18 5 abnormal placing response 0.265242699076931 0.563683224223721 0.801365659045573 0.5 18.5 18 5 absent visceral yolk sac blood islands 0.265242699076931 0.563683224223721 0.801365659045573 0.5 18.5 18 5 abnormal spleen periarteriolar lymphoid sheath morphology 0.265242699076931 0.563683224223721 0.801365659045573 0.5 18.5 18 5 abnormal kidney medulla morphology 0.265242699076931 0.563683224223721 0.801365659045573 0.5 18.5 18 5 decreased coping response 0.265242699076931 0.563683224223721 0.801365659045573 0.5 18.5 18 5 decreased vascular permeability 0.265242699076931 0.563683224223721 0.801365659045573 0.5 18.5 18 5 abnormal voluntary movement 0.265242699076931 0.563683224223721 0.801365659045573 0.5 18.5 18 5 abnormal uterus development 0.265242699076931 0.563683224223721 0.801365659045573 0.5 18.5 18 5 abnormal imprinting 0.265242699076931 0.563683224223721 0.801365659045573 0.5 18.5 18 5 abnormal decidualization 0.265242699076931 0.563683224223721 0.801365659045573 0.5 18.5 18 5 abnormal positive T cell selection 0.265242699076931 0.563683224223721 0.801365659045573 0.5 18.5 18 5 decreased CNS synapse formation 0.265242699076931 0.563683224223721 0.801365659045573 0.5 18.5 18 5 abnormal iris pigmentation 0.265242699076931 0.563683224223721 0.801365659045573 0.5 18.5 18 5 decreased cornea thickness 0.265242699076931 0.563683224223721 0.801365659045573 0.5 18.5 18 5 pulmonary alveolar hemorrhage 0.265242699076931 0.563683224223721 0.801365659045573 0.5 18.5 18 5 decreased response to antigen 0.265242699076931 0.563683224223721 0.801365659045573 0.5 18.5 18 5 abnormal otic capsule morphology 0.327856489026498 0.592515047493567 0.801365659045573 0.5 18.5 18 5 abnormal epidermis suprabasal layer morphology 0.327856489026498 0.592515047493567 0.801365659045573 0.5 18.5 18 5 myocarditis 0.293840399701183 0.592515047493567 0.801365659045573 0.5 18.5 18 5 increased litter size 0.293840399701183 0.592515047493567 0.801365659045573 0.5 18.5 18 5 abnormal gland morphology 0.327856489026498 0.592515047493567 0.801365659045573 0.5 18.5 18 5 abnormal tracheal ciliated epithelium morphology 0.293840399701183 0.592515047493567 0.801365659045573 0.5 18.5 18 5 abnormal airway responsiveness 0.327856489026498 0.592515047493567 0.801365659045573 0.5 18.5 18 5 abnormal corticospinal tract morphology 0.293840399701183 0.592515047493567 0.801365659045573 0.5 18.5 18 5 abnormal primordial germ cell migration 0.327856489026498 0.592515047493567 0.801365659045573 0.5 18.5 18 5 delayed dark adaptation 0.327856489026498 0.592515047493567 0.801365659045573 0.5 18.5 18 5 rickets 0.327856489026498 0.592515047493567 0.801365659045573 0.5 18.5 18 5 intestinal hypoperistalsis 0.327856489026498 0.592515047493567 0.801365659045573 0.5 18.5 18 5 abnormal hypaxial muscle morphology 0.327856489026498 0.592515047493567 0.801365659045573 0.5 18.5 18 5 lymphedema 0.327856489026498 0.592515047493567 0.801365659045573 0.5 18.5 18 5 absent tail 0.293840399701183 0.592515047493567 0.801365659045573 0.5 18.5 18 5 abnormal submandibular gland morphology 0.327856489026498 0.592515047493567 0.801365659045573 0.5 18.5 18 5 delayed somite formation 0.293840399701183 0.592515047493567 0.801365659045573 0.5 18.5 18 5 increased left ventricle diastolic pressure 0.327856489026498 0.592515047493567 0.801365659045573 0.5 18.5 18 5 abnormal ear physiology 0.327856489026498 0.592515047493567 0.801365659045573 0.5 18.5 18 5 abnormal reproductive system development 0.327856489026498 0.592515047493567 0.801365659045573 0.5 18.5 18 5 stria vascularis degeneration 0.293840399701183 0.592515047493567 0.801365659045573 0.5 18.5 18 5 decreased cochlear nerve compound action potential 0.293840399701183 0.592515047493567 0.801365659045573 0.5 18.5 18 5 abnormal cochlear inner hair cell physiology 0.327856489026498 0.592515047493567 0.801365659045573 0.5 18.5 18 5 increased placenta weight 0.293840399701183 0.592515047493567 0.801365659045573 0.5 18.5 18 5 abnormal B cell proliferation 0.293840399701183 0.592515047493567 0.801365659045573 0.5 18.5 18 5 abnormal anogenital distance 0.293840399701183 0.592515047493567 0.801365659045573 0.5 18.5 18 5 abnormal corneal endothelium morphology 0.327856489026498 0.592515047493567 0.801365659045573 0.5 18.5 18 5 ascites 0.327856489026498 0.592515047493567 0.801365659045573 0.5 18.5 18 5 abnormal gonadal fat pad morphology 0.327856489026498 0.592515047493567 0.801365659045573 0.5 18.5 18 5 abnormal developmental vascular remodeling 0.327856489026498 0.592515047493567 0.801365659045573 0.5 18.5 18 5 absent inguinal lymph nodes 0.327856489026498 0.592515047493567 0.801365659045573 0.5 18.5 18 5 absent axillary lymph nodes 0.327856489026498 0.592515047493567 0.801365659045573 0.5 18.5 18 5 crystalluria 0.327856489026498 0.592515047493567 0.801365659045573 0.5 18.5 18 5 ventricular premature beat 0.327856489026498 0.592515047493567 0.801365659045573 0.5 18.5 18 5 abnormal sperm principal piece morphology 0.327856489026498 0.592515047493567 0.801365659045573 0.5 18.5 18 5 umbilical hernia 0.327856489026498 0.592515047493567 0.801365659045573 0.5 18.5 18 5 increased T-helper 17 cell number 0.327856489026498 0.592515047493567 0.801365659045573 0.5 18.5 18 5 increased kidney iron level 0.327856489026498 0.592515047493567 0.801365659045573 0.5 18.5 18 5 aorta stenosis 0.327856489026498 0.592515047493567 0.801365659045573 0.5 18.5 18 5 sinus bradycardia 0.327856489026498 0.592515047493567 0.801365659045573 0.5 18.5 18 5 abnormal pulmonary interalveolar septum morphology 0.327856489026498 0.592515047493567 0.801365659045573 0.5 18.5 18 5 abnormal circadian temperature homeostasis 0.327856489026498 0.592515047493567 0.801365659045573 0.5 18.5 18 5 increased grooming behavior 0.0976804142975248 0.306020189628581 0.801365659045573 0.5 18.5 18 5 hyporesponsive to tactile stimuli 0.0976804142975248 0.306020189628581 0.801365659045573 0.5 18.5 18 5 increased circulating glucose level 0.00427945323753701 0.0317025644400768 0.795682214655179 0.49645390070922 18.5 18 5 decreased cardiac muscle contractility 0.0175224229926148 0.0935343931204491 0.785954780987004 0.490384615384615 18.5 18 5 decreased osteoclast cell number 0.0993369386521266 0.309456023665829 0.783557533289005 0.488888888888889 18.5 18 5 abnormal metabolism 0.0993369386521266 0.309456023665829 0.783557533289005 0.488888888888889 18.5 18 5 abnormal posture 0.0382200762099606 0.168418847780827 0.781331517569434 0.4875 18.5 18 5 abnormal lens fiber morphology 0.124065790592123 0.372947014015595 0.780817821634148 0.487179487179487 18.5 18 5 increased autoantibody level 0.124065790592123 0.372947014015595 0.780817821634148 0.487179487179487 18.5 18 5 impaired macrophage chemotaxis 0.124065790592123 0.372947014015595 0.780817821634148 0.487179487179487 18.5 18 5 increased white adipose tissue amount 0.133834089980843 0.379660891894382 0.779707127720017 0.486486486486487 18.5 18 5 abnormal long bone metaphysis morphology 0.133834089980843 0.379660891894382 0.779707127720017 0.486486486486487 18.5 18 5 impaired skeletal muscle contractility 0.133834089980843 0.379660891894382 0.779707127720017 0.486486486486487 18.5 18 5 skin inflammation 0.133834089980843 0.379660891894382 0.779707127720017 0.486486486486487 18.5 18 5 dehydration 0.0533861707171184 0.209137331306344 0.778469497358557 0.485714285714286 18.5 18 5 decreased systemic arterial blood pressure 0.156218191871808 0.379660891894382 0.777081851195707 0.484848484848485 18.5 18 5 abnormal immune system physiology 0.0149093978767126 0.0810903660199229 0.775515153915071 0.483870967741935 18.5 18 5 increased sensitivity to induced morbidity/mortality 0.00370577149673737 0.0283198359389684 0.775234170163652 0.483695652173913 18.5 18 5 abnormal CD8-positive, alpha-beta T cell physiology 0.183244910384012 0.424560948200518 0.773732360457795 0.482758620689655 18.5 18 5 decreased bone strength 0.183244910384012 0.424560948200518 0.773732360457795 0.482758620689655 18.5 18 5 decreased IgA level 0.0995120267131315 0.30961371663404 0.770543902928436 0.480769230769231 18.5 18 5 increased percent body fat/body weight 0.0995120267131315 0.30961371663404 0.770543902928436 0.480769230769231 18.5 18 5 obese 0.0536207034335655 0.209137331306344 0.77014362038146 0.480519480519481 18.5 18 5 abnormal vertebrae development 0.216296326649788 0.489124647764861 0.76931103268375 0.48 18.5 18 5 increased liver glycogen level 0.216296326649788 0.489124647764861 0.76931103268375 0.48 18.5 18 5 abnormal cardiovascular system morphology 0.114864246269997 0.349083460716697 0.767975423252008 0.479166666666667 18.5 18 5 abnormal immune system morphology 0.123518526469874 0.371976192002192 0.766523673869679 0.478260869565217 18.5 18 5 abnormal blood vessel physiology 0.235684414353601 0.520228314581401 0.766523673869679 0.478260869565217 18.5 18 5 bidirectional circling 0.235684414353601 0.520228314581401 0.766523673869679 0.478260869565217 18.5 18 5 hypotension 0.235684414353601 0.520228314581401 0.766523673869679 0.478260869565217 18.5 18 5 abnormal ulna morphology 0.235684414353601 0.520228314581401 0.766523673869679 0.478260869565217 18.5 18 5 abnormal corneal stroma morphology 0.235684414353601 0.520228314581401 0.766523673869679 0.478260869565217 18.5 18 5 abnormal chondrocyte physiology 0.235684414353601 0.520228314581401 0.766523673869679 0.478260869565217 18.5 18 5 abnormal hepatocyte physiology 0.235684414353601 0.520228314581401 0.766523673869679 0.478260869565217 18.5 18 5 decreased effector memory CD8-positive, alpha-beta T cell number 0.235684414353601 0.520228314581401 0.766523673869679 0.478260869565217 18.5 18 5 abnormal bile salt homeostasis 0.257423375026538 0.556493155338032 0.763205389567213 0.476190476190476 18.5 18 5 increased bone ossification 0.257423375026538 0.556493155338032 0.763205389567213 0.476190476190476 18.5 18 5 perinatal lethality 0.154246091367802 0.379660891894382 0.761297376093295 0.475 18.5 18 5 seizures 0.0317081360178617 0.146333930138091 0.759188519095806 0.473684210526316 18.5 18 5 decreased threshold for auditory brainstem response 0.166372398095828 0.389140893524563 0.759188519095806 0.473684210526316 18.5 18 5 kyphoscoliosis 0.281960962183639 0.592515047493567 0.759188519095806 0.473684210526316 18.5 18 5 flaky skin 0.281960962183639 0.592515047493567 0.759188519095806 0.473684210526316 18.5 18 5 abnormal stationary movement 0.281960962183639 0.592515047493567 0.759188519095806 0.473684210526316 18.5 18 5 stereotypic behavior 0.281960962183639 0.592515047493567 0.759188519095806 0.473684210526316 18.5 18 5 abnormal response to novelty 0.281960962183639 0.592515047493567 0.759188519095806 0.473684210526316 18.5 18 5 osteoarthritis 0.281960962183639 0.592515047493567 0.759188519095806 0.473684210526316 18.5 18 5 increased left ventricle weight 0.281960962183639 0.592515047493567 0.759188519095806 0.473684210526316 18.5 18 5 increased circulating VLDL cholesterol level 0.281960962183639 0.592515047493567 0.759188519095806 0.473684210526316 18.5 18 5 right-sided stomach 0.281960962183639 0.592515047493567 0.759188519095806 0.473684210526316 18.5 18 5 abnormal inflammatory response 0.0795224323551992 0.262897574327077 0.756845344654152 0.472222222222222 18.5 18 5 abnormal eye electrophysiology 0.0314477672726048 0.145267077234177 0.755005662241284 0.471074380165289 18.5 18 5 decreased susceptibility to injury 0.0909380711345855 0.286702727436352 0.754226502631128 0.470588235294118 18.5 18 5 abnormal bone remodeling 0.194127265273273 0.445061357020523 0.754226502631128 0.470588235294118 18.5 18 5 increased width of hypertrophic chondrocyte zone 0.194127265273273 0.445061357020523 0.754226502631128 0.470588235294118 18.5 18 5 decreased cytotoxic T cell cytolysis 0.194127265273273 0.445061357020523 0.754226502631128 0.470588235294118 18.5 18 5 abnormal adipose tissue morphology 0.309884873162497 0.592515047493567 0.754226502631128 0.470588235294118 18.5 18 5 abnormal touch/ nociception 0.309884873162497 0.592515047493567 0.754226502631128 0.470588235294118 18.5 18 5 absence seizures 0.309884873162497 0.592515047493567 0.754226502631128 0.470588235294118 18.5 18 5 abnormal involuntary movement 0.309884873162497 0.592515047493567 0.754226502631128 0.470588235294118 18.5 18 5 decreased growth hormone level 0.309884873162497 0.592515047493567 0.754226502631128 0.470588235294118 18.5 18 5 increased circulating magnesium level 0.309884873162497 0.592515047493567 0.754226502631128 0.470588235294118 18.5 18 5 abnormal ductus venosus valve morphology 0.309884873162497 0.592515047493567 0.754226502631128 0.470588235294118 18.5 18 5 abnormal trabecular bone morphology 0.0334533445479687 0.15224917440951 0.754226502631128 0.470588235294118 18.5 18 5 abnormal lymphatic vessel morphology 0.210046222511603 0.479788777316448 0.751280305355225 0.46875 18.5 18 5 bradykinesia 0.210046222511603 0.479788777316448 0.751280305355225 0.46875 18.5 18 5 abnormal T-helper 1 physiology 0.150923164907367 0.379660891894382 0.750214659532026 0.468085106382979 18.5 18 5 increased eosinophil cell number 0.111450463595394 0.342474401721487 0.749664648784568 0.467741935483871 18.5 18 5 lethality at weaning, complete penetrance 0.162293060505462 0.381361985069474 0.747941281775868 0.466666666666667 18.5 18 5 abnormal epidermis stratum spinosum morphology 0.341990056967297 0.592515047493567 0.747941281775868 0.466666666666667 18.5 18 5 placental labyrinth hypoplasia 0.341990056967297 0.592515047493567 0.747941281775868 0.466666666666667 18.5 18 5 decreased aggression towards males 0.341990056967297 0.592515047493567 0.747941281775868 0.466666666666667 18.5 18 5 abnormal neurotransmitter secretion 0.341990056967297 0.592515047493567 0.747941281775868 0.466666666666667 18.5 18 5 absent chorion 0.341990056967297 0.592515047493567 0.747941281775868 0.466666666666667 18.5 18 5 abnormal aorta wall morphology 0.341990056967297 0.592515047493567 0.747941281775868 0.466666666666667 18.5 18 5 short femur 0.0721293939861047 0.257279635540005 0.746727091383375 0.465909090909091 18.5 18 5 abnormal intestinal mucosa morphology 0.174632731292575 0.407312629245457 0.745456427019138 0.465116279069767 18.5 18 5 enhanced coordination 0.246893027750704 0.541575314400244 0.744125254828032 0.464285714285714 18.5 18 5 abnormal response/metabolism to endogenous compounds 0.087452683210478 0.27606414909399 0.742729147408092 0.463414634146341 18.5 18 5 short ulna 0.188042288923507 0.433910198234901 0.742729147408092 0.463414634146341 18.5 18 5 increased neutrophil cell number 0.0333874183203833 0.15224917440951 0.740572402152461 0.462068965517241 18.5 18 5 decreased monocyte cell number 0.124511860689184 0.374061900319257 0.739722146811298 0.461538461538462 18.5 18 5 pulmonary edema 0.268300548530517 0.569938184858806 0.739722146811298 0.461538461538462 18.5 18 5 short hair 0.379392569951194 0.592515047493567 0.739722146811298 0.461538461538462 18.5 18 5 abnormal renal/urinary system morphology 0.379392569951194 0.592515047493567 0.739722146811298 0.461538461538462 18.5 18 5 abnormal sympathetic ganglion morphology 0.379392569951194 0.592515047493567 0.739722146811298 0.461538461538462 18.5 18 5 small trigeminal ganglion 0.379392569951194 0.592515047493567 0.739722146811298 0.461538461538462 18.5 18 5 tight skin 0.379392569951194 0.592515047493567 0.739722146811298 0.461538461538462 18.5 18 5 pup cannibalization 0.379392569951194 0.592515047493567 0.739722146811298 0.461538461538462 18.5 18 5 abnormal digestion 0.379392569951194 0.592515047493567 0.739722146811298 0.461538461538462 18.5 18 5 abnormal dopaminergic neuron morphology 0.379392569951194 0.592515047493567 0.739722146811298 0.461538461538462 18.5 18 5 muscle fatigue 0.379392569951194 0.592515047493567 0.739722146811298 0.461538461538462 18.5 18 5 small interparietal bone 0.379392569951194 0.592515047493567 0.739722146811298 0.461538461538462 18.5 18 5 decreased endocochlear potential 0.379392569951194 0.592515047493567 0.739722146811298 0.461538461538462 18.5 18 5 hyperalgesia 0.379392569951194 0.592515047493567 0.739722146811298 0.461538461538462 18.5 18 5 increased renin activity 0.379392569951194 0.592515047493567 0.739722146811298 0.461538461538462 18.5 18 5 abnormal hair follicle inner root sheath morphology 0.379392569951194 0.592515047493567 0.739722146811298 0.461538461538462 18.5 18 5 abnormal T cell activation 0.113303866747299 0.347734536739401 0.736390065068905 0.459459459459459 18.5 18 5 abnormal NK cell physiology 0.142444200396825 0.379660891894382 0.735679949287739 0.459016393442623 18.5 18 5 increased susceptibility to pharmacologically induced seizures 0.0831833739942688 0.264095268424689 0.734585187458442 0.458333333333333 18.5 18 5 abnormal humoral immune response 0.0761362881674453 0.259437009337699 0.732677173984524 0.457142857142857 18.5 18 5 abnormal intestinal goblet cell morphology 0.235906548280531 0.520228314581401 0.732677173984524 0.457142857142857 18.5 18 5 decreased circulating thyroxine level 0.235906548280531 0.520228314581401 0.732677173984524 0.457142857142857 18.5 18 5 decreased bone volume 0.235906548280531 0.520228314581401 0.732677173984524 0.457142857142857 18.5 18 5 impaired natural killer cell mediated cytotoxicity 0.163145536731298 0.381772834072535 0.731070425795961 0.456140350877193 18.5 18 5 decreased food intake 0.117228172595821 0.356050157914657 0.730358575332674 0.455696202531646 18.5 18 5 abnormal gametogenesis 0.209398726558133 0.478749386317422 0.728514235495976 0.454545454545455 18.5 18 5 increased body size 0.318688441590174 0.592515047493567 0.728514235495976 0.454545454545455 18.5 18 5 testis hypoplasia 0.318688441590174 0.592515047493567 0.728514235495976 0.454545454545455 18.5 18 5 increased coping response 0.318688441590174 0.592515047493567 0.728514235495976 0.454545454545455 18.5 18 5 abnormal retinal outer plexiform layer morphology 0.318688441590174 0.592515047493567 0.728514235495976 0.454545454545455 18.5 18 5 decreased susceptibility to viral infection induced morbidity/mortality 0.318688441590174 0.592515047493567 0.728514235495976 0.454545454545455 18.5 18 5 increased bone volume 0.318688441590174 0.592515047493567 0.728514235495976 0.454545454545455 18.5 18 5 impaired humoral immune response 0.318688441590174 0.592515047493567 0.728514235495976 0.454545454545455 18.5 18 5 abnormal ear position 0.423734714835554 0.637074707255026 0.728514235495976 0.454545454545455 18.5 18 5 absent semicircular canals 0.423734714835554 0.637074707255026 0.728514235495976 0.454545454545455 18.5 18 5 secondary sex reversal 0.423734714835554 0.637074707255026 0.728514235495976 0.454545454545455 18.5 18 5 rectal hemorrhage 0.423734714835554 0.637074707255026 0.728514235495976 0.454545454545455 18.5 18 5 abnormal lymph circulation 0.423734714835554 0.637074707255026 0.728514235495976 0.454545454545455 18.5 18 5 enlarged placenta 0.423734714835554 0.637074707255026 0.728514235495976 0.454545454545455 18.5 18 5 abnormal spinal cord ventral horn morphology 0.423734714835554 0.637074707255026 0.728514235495976 0.454545454545455 18.5 18 5 abnormal platelet aggregation 0.423734714835554 0.637074707255026 0.728514235495976 0.454545454545455 18.5 18 5 abnormal aorta smooth muscle morphology 0.423734714835554 0.637074707255026 0.728514235495976 0.454545454545455 18.5 18 5 decreased core body temperature 0.423734714835554 0.637074707255026 0.728514235495976 0.454545454545455 18.5 18 5 abnormal phrenic nerve innervation pattern to diaphragm 0.423734714835554 0.637074707255026 0.728514235495976 0.454545454545455 18.5 18 5 absent vibrissae 0.254902914711432 0.556493155338032 0.728514235495975 0.454545454545455 18.5 18 5 head tossing 0.254902914711432 0.556493155338032 0.728514235495975 0.454545454545455 18.5 18 5 decreased sensitivity to xenobiotic induced morbidity/mortality 0.254902914711432 0.556493155338032 0.728514235495975 0.454545454545455 18.5 18 5 decreased inflammatory response 0.120772917117972 0.36592281526304 0.725045120088852 0.452380952380952 18.5 18 5 abnormal optic nerve morphology 0.22514646849065 0.505690149318729 0.725045120088852 0.452380952380952 18.5 18 5 absent mature ovarian follicles 0.275726652179083 0.584963793002531 0.723814143654066 0.451612903225806 18.5 18 5 abnormal retinal photoreceptor layer morphology 0.275726652179083 0.584963793002531 0.723814143654066 0.451612903225806 18.5 18 5 abnormal intestine physiology 0.275726652179083 0.584963793002531 0.723814143654066 0.451612903225806 18.5 18 5 abnormal thrombosis 0.200450138608094 0.458790913125265 0.722800398354831 0.450980392156863 18.5 18 5 head bobbing 0.242226297112848 0.531572928158985 0.721229093141016 0.45 18.5 18 5 increased susceptibility to weight loss 0.242226297112848 0.531572928158985 0.721229093141016 0.45 18.5 18 5 abnormal fibula morphology 0.34854789607757 0.592515047493567 0.721229093141016 0.45 18.5 18 5 abnormal male reproductive system physiology 0.34854789607757 0.592515047493567 0.721229093141016 0.45 18.5 18 5 abnormal thymocyte activation 0.34854789607757 0.592515047493567 0.721229093141016 0.45 18.5 18 5 abnormal circulating cytokine level 0.34854789607757 0.592515047493567 0.721229093141016 0.45 18.5 18 5 abnormal circulating glucose level 0.298607123111142 0.592515047493567 0.718465763282238 0.448275862068966 18.5 18 5 decreased retinal photoreceptor cell number 0.298607123111142 0.592515047493567 0.718465763282238 0.448275862068966 18.5 18 5 increased retinal apoptosis 0.298607123111142 0.592515047493567 0.718465763282238 0.448275862068966 18.5 18 5 circling 0.140081220697154 0.379660891894382 0.716515177499571 0.447058823529412 18.5 18 5 abnormal T cell differentiation 0.122145038790946 0.369854880088228 0.714088211030709 0.445544554455446 18.5 18 5 lowered ear position 0.382302505535845 0.592515047493567 0.712325030262732 0.444444444444444 18.5 18 5 abnormal systemic arterial blood pressure 0.280934639324168 0.592515047493567 0.712325030262732 0.444444444444444 18.5 18 5 abnormal heart shape 0.382302505535845 0.592515047493567 0.712325030262732 0.444444444444444 18.5 18 5 abnormal retinal rod cell morphology 0.382302505535845 0.592515047493567 0.712325030262732 0.444444444444444 18.5 18 5 acidosis 0.382302505535845 0.592515047493567 0.712325030262732 0.444444444444444 18.5 18 5 skin lesions 0.195816524937782 0.448727412052264 0.712325030262732 0.444444444444444 18.5 18 5 abnormal cochlea morphology 0.219262088688976 0.49292235440906 0.712325030262732 0.444444444444444 18.5 18 5 abnormal ovarian follicle morphology 0.247083259400269 0.541753730945941 0.712325030262732 0.444444444444444 18.5 18 5 impaired righting response 0.145623062260675 0.379660891894382 0.708575951156086 0.442105263157895 18.5 18 5 abnormal male reproductive system morphology 0.265136510439127 0.563683224223721 0.708183605668181 0.441860465116279 18.5 18 5 abnormal nervous system electrophysiology 0.171045517958129 0.399132951145258 0.705964985349672 0.44047619047619 18.5 18 5 abnormal inner ear vestibule morphology 0.351663839322355 0.592515047493567 0.705201779960104 0.44 18.5 18 5 abnormal primitive streak morphology 0.351663839322355 0.592515047493567 0.705201779960104 0.44 18.5 18 5 abnormal feces composition 0.351663839322355 0.592515047493567 0.705201779960104 0.44 18.5 18 5 abnormal crypts of Lieberkuhn morphology 0.326811430809345 0.592515047493567 0.701194951664876 0.4375 18.5 18 5 abnormal diaphragm morphology 0.326811430809345 0.592515047493567 0.701194951664876 0.4375 18.5 18 5 absent mandible 0.420761588982723 0.637074707255026 0.701194951664876 0.4375 18.5 18 5 abnormal bone marrow cell number 0.420761588982723 0.637074707255026 0.701194951664876 0.4375 18.5 18 5 mixed cellular infiltration to dermis 0.420761588982723 0.637074707255026 0.701194951664876 0.4375 18.5 18 5 abnormal extraembryonic endoderm formation 0.420761588982723 0.637074707255026 0.701194951664876 0.4375 18.5 18 5 decreased aggression towards mice 0.420761588982723 0.637074707255026 0.701194951664876 0.4375 18.5 18 5 bowed tibia 0.420761588982723 0.637074707255026 0.701194951664876 0.4375 18.5 18 5 abnormal wound healing 0.420761588982723 0.637074707255026 0.701194951664876 0.4375 18.5 18 5 abnormal level of surface class II molecules 0.420761588982723 0.637074707255026 0.701194951664876 0.4375 18.5 18 5 abnormal urinary bladder physiology 0.420761588982723 0.637074707255026 0.701194951664876 0.4375 18.5 18 5 decreased adipocyte glucose uptake 0.420761588982723 0.637074707255026 0.701194951664876 0.4375 18.5 18 5 decreased trabecular bone volume 0.305696138095366 0.592515047493567 0.698626471988448 0.435897435897436 18.5 18 5 abnormal food intake 0.228259946328629 0.512451819939048 0.69683970351789 0.434782608695652 18.5 18 5 abnormal inner ear morphology 0.287252175019434 0.592515047493567 0.69683970351789 0.434782608695652 18.5 18 5 conjunctivitis 0.382537693310615 0.592515047493567 0.69683970351789 0.434782608695652 18.5 18 5 abnormal B cell morphology 0.382537693310615 0.592515047493567 0.69683970351789 0.434782608695652 18.5 18 5 gastrointestinal hemorrhage 0.352935665009668 0.592515047493567 0.694516904506163 0.433333333333333 18.5 18 5 increased brown adipose tissue amount 0.328472896106882 0.592515047493567 0.693073002417793 0.432432432432432 18.5 18 5 hypertension 0.307497226188682 0.592515047493567 0.692088523721177 0.431818181818182 18.5 18 5 decreased sensitivity to induced morbidity/mortality 0.307497226188682 0.592515047493567 0.692088523721177 0.431818181818182 18.5 18 5 abnormal stria vascularis morphology 0.381503761611661 0.592515047493567 0.686884850610491 0.428571428571429 18.5 18 5 abnormal stapes morphology 0.416891286865844 0.637074707255026 0.686884850610491 0.428571428571429 18.5 18 5 absent atrioventricular cushions 0.465004973106891 0.693049652848048 0.686884850610491 0.428571428571429 18.5 18 5 abnormal zigzag hair morphology 0.465004973106891 0.693049652848048 0.686884850610491 0.428571428571429 18.5 18 5 increased aggression towards males 0.465004973106891 0.693049652848048 0.686884850610491 0.428571428571429 18.5 18 5 extended life span 0.465004973106891 0.693049652848048 0.686884850610491 0.428571428571429 18.5 18 5 abnormal antigen presentation 0.465004973106891 0.693049652848048 0.686884850610491 0.428571428571429 18.5 18 5 absent otoliths 0.465004973106891 0.693049652848048 0.686884850610491 0.428571428571429 18.5 18 5 enlarged stomach 0.465004973106891 0.693049652848048 0.686884850610491 0.428571428571429 18.5 18 5 abnormal pancreas development 0.465004973106891 0.693049652848048 0.686884850610491 0.428571428571429 18.5 18 5 increased lung compliance 0.465004973106891 0.693049652848048 0.686884850610491 0.428571428571429 18.5 18 5 decreased compact bone area 0.465004973106891 0.693049652848048 0.686884850610491 0.428571428571429 18.5 18 5 abnormal respiratory motile cilium physiology 0.465004973106891 0.693049652848048 0.686884850610491 0.428571428571429 18.5 18 5 abnormal osteoblast physiology 0.30911301641185 0.592515047493567 0.682644820668451 0.425925925925926 18.5 18 5 abnormal aorta morphology 0.379796653197281 0.592515047493567 0.679946619796244 0.424242424242424 18.5 18 5 abnormal T cell subpopulation ratio 0.379796653197281 0.592515047493567 0.679946619796244 0.424242424242424 18.5 18 5 abnormal middle ear ossicle morphology 0.379796653197281 0.592515047493567 0.679946619796244 0.424242424242424 18.5 18 5 no spontaneous movement 0.41279691923637 0.636006402353961 0.678078634577023 0.423076923076923 18.5 18 5 decreased Peyer's patch number 0.41279691923637 0.636006402353961 0.678078634577023 0.423076923076923 18.5 18 5 decreased susceptibility to induced arthritis 0.328497762789121 0.592515047493567 0.674834239196272 0.421052631578947 18.5 18 5 decreased grooming behavior 0.45527817342836 0.681410623587873 0.674834239196272 0.421052631578947 18.5 18 5 altered susceptibility to infection 0.45527817342836 0.681410623587873 0.674834239196272 0.421052631578947 18.5 18 5 abnormal neurotransmitter level 0.45527817342836 0.681410623587873 0.674834239196272 0.421052631578947 18.5 18 5 abnormal photoreceptor inner segment morphology 0.45527817342836 0.681410623587873 0.674834239196272 0.421052631578947 18.5 18 5 absent amnion 0.45527817342836 0.681410623587873 0.674834239196272 0.421052631578947 18.5 18 5 decreased fertilization frequency 0.45527817342836 0.681410623587873 0.674834239196272 0.421052631578947 18.5 18 5 abnormal body temperature homeostasis 0.408697729831757 0.630080943883791 0.672113133393061 0.419354838709677 18.5 18 5 increased susceptibility to bacterial infection induced morbidity/mortality 0.32542182930492 0.592515047493567 0.667804715871311 0.416666666666667 18.5 18 5 small lymph nodes 0.447134521570751 0.670617890526782 0.667804715871311 0.416666666666667 18.5 18 5 decreased ovulation rate 0.447134521570751 0.670617890526782 0.667804715871311 0.416666666666667 18.5 18 5 abnormal osteoblast morphology 0.447134521570751 0.670617890526782 0.667804715871311 0.416666666666667 18.5 18 5 abnormal retinal ganglion layer morphology 0.447134521570751 0.670617890526782 0.667804715871311 0.416666666666667 18.5 18 5 abnormal supraoccipital bone morphology 0.516516368502962 0.731474219556571 0.667804715871311 0.416666666666667 18.5 18 5 abnormal superior cervical ganglion morphology 0.516516368502962 0.731474219556571 0.667804715871311 0.416666666666667 18.5 18 5 abnormal enteric nervous system morphology 0.516516368502962 0.731474219556571 0.667804715871311 0.416666666666667 18.5 18 5 absent optic nerve 0.516516368502962 0.731474219556571 0.667804715871311 0.416666666666667 18.5 18 5 ear inflammation 0.516516368502962 0.731474219556571 0.667804715871311 0.416666666666667 18.5 18 5 increased urine phosphate level 0.516516368502962 0.731474219556571 0.667804715871311 0.416666666666667 18.5 18 5 increased circulating parathyroid hormone level 0.516516368502962 0.731474219556571 0.667804715871311 0.416666666666667 18.5 18 5 impaired sperm capacitation 0.516516368502962 0.731474219556571 0.667804715871311 0.416666666666667 18.5 18 5 vestibular saccular macula degeneration 0.516516368502962 0.731474219556571 0.667804715871311 0.416666666666667 18.5 18 5 bowed ulna 0.516516368502962 0.731474219556571 0.667804715871311 0.416666666666667 18.5 18 5 small parietal bone 0.516516368502962 0.731474219556571 0.667804715871311 0.416666666666667 18.5 18 5 abnormal amacrine cell morphology 0.516516368502962 0.731474219556571 0.667804715871311 0.416666666666667 18.5 18 5 abnormal somatic nervous system physiology 0.516516368502962 0.731474219556571 0.667804715871311 0.416666666666667 18.5 18 5 decreased keratinocyte proliferation 0.516516368502962 0.731474219556571 0.667804715871311 0.416666666666667 18.5 18 5 reduced cerebellar foliation 0.516516368502962 0.731474219556571 0.667804715871311 0.416666666666667 18.5 18 5 increased type II pneumocyte number 0.516516368502962 0.731474219556571 0.667804715871311 0.416666666666667 18.5 18 5 abnormal respiratory motile cilium morphology 0.516516368502962 0.731474219556571 0.667804715871311 0.416666666666667 18.5 18 5 decreased compensatory feeding amount 0.516516368502962 0.731474219556571 0.667804715871311 0.416666666666667 18.5 18 5 impaired fertilization 0.343672699432374 0.592515047493567 0.663988688923475 0.414285714285714 18.5 18 5 enlarged epididymis 0.440019035847322 0.660759041153162 0.663199166106681 0.413793103448276 18.5 18 5 decreased regulatory T cell number 0.433635727026814 0.651566820283419 0.659948189802237 0.411764705882353 18.5 18 5 decreased osteoblast cell number 0.433635727026814 0.651566820283419 0.659948189802237 0.411764705882353 18.5 18 5 abnormal glutamate-mediated receptor currents 0.498375290056881 0.709824525632116 0.659948189802237 0.411764705882353 18.5 18 5 decreased vasoconstriction 0.498375290056881 0.709824525632116 0.659948189802237 0.411764705882353 18.5 18 5 nephrocalcinosis 0.498375290056881 0.709824525632116 0.659948189802237 0.411764705882353 18.5 18 5 abnormal electroretinogram waveform feature 0.498375290056881 0.709824525632116 0.659948189802237 0.411764705882353 18.5 18 5 decreased body fat mass 0.498375290056881 0.709824525632116 0.659948189802237 0.411764705882353 18.5 18 5 increased activated T cell number 0.484877872056693 0.709387039133757 0.655662811946378 0.409090909090909 18.5 18 5 abnormal single cell response 0.473973056330246 0.705878687712064 0.652964611074171 0.407407407407407 18.5 18 5 decreased circulating chloride level 0.456631069090227 0.68302452457122 0.649755939766681 0.405405405405405 18.5 18 5 increased insulin secretion 0.456631069090227 0.68302452457122 0.649755939766681 0.405405405405405 18.5 18 5 abnormal leukocyte migration 0.436745016984954 0.656040597675165 0.647256878459886 0.403846153846154 18.5 18 5 increased susceptibility to parasitic infection 0.417734793058117 0.637074707255026 0.641092527236458 0.4 18.5 18 5 impaired ovarian folliculogenesis 0.477938038927123 0.706190004057748 0.641092527236458 0.4 18.5 18 5 impaired behavioral response to xenobiotic 0.487315180170683 0.709387039133757 0.641092527236458 0.4 18.5 18 5 decreased acute inflammation 0.510781643069682 0.727078304512637 0.641092527236458 0.4 18.5 18 5 brain inflammation 0.52643169166222 0.744244861045622 0.641092527236458 0.4 18.5 18 5 abnormal hearing physiology 0.52643169166222 0.744244861045622 0.641092527236458 0.4 18.5 18 5 decreased paired-pulse facilitation 0.52643169166222 0.744244861045622 0.641092527236458 0.4 18.5 18 5 abnormal incus morphology 0.52643169166222 0.744244861045622 0.641092527236458 0.4 18.5 18 5 increased urine calcium level 0.52643169166222 0.744244861045622 0.641092527236458 0.4 18.5 18 5 decreased chondrocyte number 0.547014917199954 0.762937822559509 0.641092527236458 0.4 18.5 18 5 abnormal enteric neuron morphology 0.547014917199954 0.762937822559509 0.641092527236458 0.4 18.5 18 5 hyperpigmentation 0.547014917199954 0.762937822559509 0.641092527236458 0.4 18.5 18 5 abnormal respiratory system morphology 0.547014917199954 0.762937822559509 0.641092527236458 0.4 18.5 18 5 abnormal zygomatic bone morphology 0.547014917199954 0.762937822559509 0.641092527236458 0.4 18.5 18 5 abnormal dendritic cell morphology 0.547014917199954 0.762937822559509 0.641092527236458 0.4 18.5 18 5 abnormal Muller cell morphology 0.547014917199954 0.762937822559509 0.641092527236458 0.4 18.5 18 5 ostium primum atrial septal defect 0.547014917199954 0.762937822559509 0.641092527236458 0.4 18.5 18 5 decreased trabecular bone mass 0.547014917199954 0.762937822559509 0.641092527236458 0.4 18.5 18 5 abnormal excitatory postsynaptic currents 0.447258323772435 0.670617890526782 0.636982959754174 0.397435897435897 18.5 18 5 abnormal kidney physiology 0.488560477829773 0.709387039133757 0.634414480077745 0.395833333333333 18.5 18 5 abnormal compact bone morphology 0.508101456358458 0.723470161815492 0.632657099246505 0.394736842105263 18.5 18 5 abnormal CNS synaptic transmission 0.458730436183011 0.685958497147725 0.631379004096512 0.393939393939394 18.5 18 5 diarrhea 0.519928751435259 0.73609719362277 0.631379004096512 0.393939393939394 18.5 18 5 arrested B cell differentiation 0.527332414319689 0.745306466261492 0.62545612413313 0.390243902439024 18.5 18 5 head tilt 0.539904351996456 0.762482203420373 0.62328440147989 0.388888888888889 18.5 18 5 abnormal thymus cortex morphology 0.572239789297539 0.796779443536316 0.62328440147989 0.388888888888889 18.5 18 5 abnormal sperm axoneme morphology 0.572239789297539 0.796779443536316 0.62328440147989 0.388888888888889 18.5 18 5 autoimmune response 0.554523176347233 0.772976408609551 0.620412123132057 0.387096774193548 18.5 18 5 abnormal T cell proliferation 0.554523176347233 0.772976408609551 0.620412123132057 0.387096774193548 18.5 18 5 small seminal vesicle 0.572022095465501 0.796779443536316 0.616435122342749 0.384615384615385 18.5 18 5 abnormal tectorial membrane morphology 0.572022095465501 0.796779443536316 0.616435122342749 0.384615384615385 18.5 18 5 abnormal mast cell morphology 0.602218742597817 0.801801360293131 0.616435122342749 0.384615384615385 18.5 18 5 excessive scratching 0.602218742597817 0.801801360293131 0.616435122342749 0.384615384615385 18.5 18 5 absent lateral semicircular canal 0.602218742597817 0.801801360293131 0.616435122342749 0.384615384615385 18.5 18 5 abnormal GABAergic neuron morphology 0.602218742597817 0.801801360293131 0.616435122342749 0.384615384615385 18.5 18 5 abnormal insulin secretion 0.602218742597817 0.801801360293131 0.616435122342749 0.384615384615385 18.5 18 5 abnormal retinal inner plexiform layer morphology 0.602218742597817 0.801801360293131 0.616435122342749 0.384615384615385 18.5 18 5 increased circulating thyroid-stimulating hormone level 0.602218742597817 0.801801360293131 0.616435122342749 0.384615384615385 18.5 18 5 decreased luteinizing hormone level 0.602218742597817 0.801801360293131 0.616435122342749 0.384615384615385 18.5 18 5 abnormal anxiety-related response 0.593841171536912 0.801801360293131 0.61056431165377 0.380952380952381 18.5 18 5 hypoalgesia 0.593841171536912 0.801801360293131 0.61056431165377 0.380952380952381 18.5 18 5 abnormal digestive system physiology 0.577523652772443 0.80099809661079 0.609037900874636 0.38 18.5 18 5 decreased metastatic potential 0.612788066201365 0.801801360293131 0.60102424428418 0.375 18.5 18 5 abnormal sensory capabilities/reflexes/nociception 0.612788066201365 0.801801360293131 0.60102424428418 0.375 18.5 18 5 abnormal serotonin level 0.608401963605213 0.801801360293131 0.60102424428418 0.375 18.5 18 5 abnormal epididymis epithelium morphology 0.622766914130292 0.803075530792692 0.60102424428418 0.375 18.5 18 5 decreased circulating prolactin level 0.622766914130292 0.803075530792692 0.60102424428418 0.375 18.5 18 5 dystonia 0.622766914130292 0.803075530792692 0.60102424428418 0.375 18.5 18 5 abnormal intestinal lipid absorption 0.622766914130292 0.803075530792692 0.60102424428418 0.375 18.5 18 5 abnormal Langerhans cell physiology 0.622766914130292 0.803075530792692 0.60102424428418 0.375 18.5 18 5 increased heart left ventricle size 0.622766914130292 0.803075530792692 0.60102424428418 0.375 18.5 18 5 abnormal long term depression 0.64046739855456 0.814084135873515 0.590479959296738 0.368421052631579 18.5 18 5 abnormal inhibitory postsynaptic currents 0.654447282269769 0.825945009967554 0.589239455180568 0.367647058823529 18.5 18 5 arrested T cell differentiation 0.644989113115914 0.819622180779482 0.587668149966754 0.366666666666667 18.5 18 5 abnormal long bone epiphysis morphology 0.656105914097038 0.827198916024521 0.58281138839678 0.363636363636364 18.5 18 5 intestinal ulcer 0.656105914097038 0.827198916024521 0.58281138839678 0.363636363636364 18.5 18 5 abnormal channel response 0.656105914097038 0.827198916024521 0.58281138839678 0.363636363636364 18.5 18 5 abnormal temporal bone morphology 0.656105914097038 0.827198916024521 0.58281138839678 0.363636363636364 18.5 18 5 decreased macrophage cell number 0.664690438486565 0.836776428348703 0.58281138839678 0.363636363636364 18.5 18 5 increased systemic arterial blood pressure 0.676404316086914 0.850634851499595 0.579711327820202 0.361702127659574 18.5 18 5 abnormal vasoconstriction 0.67844861453722 0.851913643948175 0.572404042175409 0.357142857142857 18.5 18 5 abnormal olfactory system physiology 0.67844861453722 0.851913643948175 0.572404042175409 0.357142857142857 18.5 18 5 abnormal endplate potential 0.67844861453722 0.851913643948175 0.572404042175409 0.357142857142857 18.5 18 5 abnormal prepulse inhibition 0.67844861453722 0.851913643948175 0.572404042175409 0.357142857142857 18.5 18 5 skeletal muscle necrosis 0.67844861453722 0.851913643948175 0.572404042175409 0.357142857142857 18.5 18 5 increased B-1 B cell number 0.67844861453722 0.851913643948175 0.572404042175409 0.357142857142857 18.5 18 5 enlarged sebaceous gland 0.690616890897609 0.866974270051881 0.565669876973346 0.352941176470588 18.5 18 5 thin skin 0.70565436235944 0.88495852098266 0.565669876973346 0.352941176470588 18.5 18 5 decreased skin tensile strength 0.701871240727359 0.88043606218321 0.560955961331901 0.35 18.5 18 5 enhanced behavioral response to xenobiotic 0.701871240727359 0.88043606218321 0.560955961331901 0.35 18.5 18 5 nuclear cataracts 0.701871240727359 0.88043606218321 0.560955961331901 0.35 18.5 18 5 abnormal retinal cone cell morphology 0.712339475234186 0.892892136379459 0.557471762814312 0.347826086956522 18.5 18 5 increased susceptibility to fungal infection 0.712339475234186 0.892892136379459 0.557471762814312 0.347826086956522 18.5 18 5 increased dopamine level 0.739972881294317 0.913822705448585 0.550938890593831 0.34375 18.5 18 5 decreased susceptibility to parasitic infection 0.739972881294317 0.913822705448585 0.550938890593831 0.34375 18.5 18 5 increased airway responsiveness 0.744165463205853 0.913822705448585 0.534243772697049 0.333333333333333 18.5 18 5 joint inflammation 0.744165463205853 0.913822705448585 0.534243772697049 0.333333333333333 18.5 18 5 abnormal synaptic transmission 0.774476125820206 0.923099838513542 0.534243772697049 0.333333333333333 18.5 18 5 abnormal reflex 0.786327725955558 0.937001302186563 0.534243772697049 0.333333333333333 18.5 18 5 abnormal malleus morphology 0.762115179750596 0.913822705448585 0.534243772697049 0.333333333333333 18.5 18 5 abnormal startle reflex 0.762115179750596 0.913822705448585 0.534243772697049 0.333333333333333 18.5 18 5 dry skin 0.755886275322583 0.913822705448585 0.534243772697049 0.333333333333333 18.5 18 5 abnormal cellular extravasation 0.762115179750596 0.913822705448585 0.534243772697049 0.333333333333333 18.5 18 5 decreased bone trabecula number 0.857638691043614 0.994665158571143 0.511509995135472 0.319148936170213 18.5 18 5 decreased cochlear coiling 0.799346621876562 0.951375465032511 0.500853536903483 0.3125 18.5 18 5 bowed radius 0.799346621876562 0.951375465032511 0.500853536903483 0.3125 18.5 18 5 increased circulating estradiol level 0.799346621876562 0.951375465032511 0.500853536903483 0.3125 18.5 18 5 abnormal pancreatic alpha cell morphology 0.799346621876562 0.951375465032511 0.500853536903483 0.3125 18.5 18 5 abnormal fertilization 0.799346621876562 0.951375465032511 0.500853536903483 0.3125 18.5 18 5 stomach inflammation 0.84363528014237 0.993406919064772 0.497399374580011 0.310344827586207 18.5 18 5 abnormal leukocyte adhesion 0.875518951937818 1 0.493148097874199 0.307692307692308 18.5 18 5 increased susceptibility to age related obesity 0.841873992683393 0.993406919064772 0.487787792462523 0.304347826086957 18.5 18 5 abnormal regulatory T cell physiology 0.841873992683393 0.993406919064772 0.487787792462523 0.304347826086957 18.5 18 5 increased aggression towards mice 0.844650676451126 0.993406919064772 0.471391564144455 0.294117647058824 18.5 18 5 abnormal heart rate 0.844650676451126 0.993406919064772 0.471391564144455 0.294117647058824 18.5 18 5 increased vasoconstriction 0.877061053269608 1 0.457923233740328 0.285714285714286 18.5 18 5 increased circulating luteinizing hormone level 0.899484710781749 1 0.457923233740327 0.285714285714286 18.5 18 5 decreased heart rate variability 0.881129612894774 1 0.445203143914207 0.277777777777778 18.5 18 5 abnormal behavioral response to xenobiotic 0.91000834824379 1 0.42177139949767 0.263157894736842 18.5 18 5 abnormal crista ampullaris morphology 0.927333927938876 1 0.418103822110734 0.260869565217391 18.5 18 5 impaired conditioned place preference behavior 0.958513954189015 1 0.384655516341875 0.24 18.5 18 5 decreased airway responsiveness 0.963049676992079 1 0.364257117747988 0.227272727272727 18.5 18 5 elevated level of mitotic sister chromatid exchange 0.000332643936417306 0.00318863888954932 1.72066725479188 1 18.1 18 1 thin stria vascularis 0.000332643936417306 0.00318863888954932 1.72066725479188 1 18.1 18 1 abnormal hair follicle melanocyte morphology 0.000332643936417306 0.00318863888954932 1.72066725479188 1 18.1 18 1 absent ectoplacental cone 0.00246386516085518 0.0164754424398582 1.72066725479188 1 18.1 18 1 abnormal hippocampal fimbria morphology 0.00246386516085518 0.0164754424398582 1.72066725479188 1 18.1 18 1 bile duct inflammation 0.00246386516085518 0.0164754424398582 1.72066725479188 1 18.1 18 1 decreased prostate gland weight 0.00246386516085518 0.0164754424398582 1.72066725479188 1 18.1 18 1 delayed limb development 0.00246386516085518 0.0164754424398582 1.72066725479188 1 18.1 18 1 ectopic bone 0.00246386516085518 0.0164754424398582 1.72066725479188 1 18.1 18 1 retarded hair growth 4.49008023539184e-05 0.000575725494099856 1.72066725479188 1 18.1 18 1 renal tubular acidosis 0.000122215947980188 0.00138187350273054 1.72066725479188 1 18.1 18 1 increased neuronal precursor cell number 0.000122215947980188 0.00138187350273054 1.72066725479188 1 18.1 18 1 mammary gland hyperplasia 0.000905334969624922 0.00722960108167574 1.72066725479188 1 18.1 18 1 abnormal brain ventricular system morphology 0.000905334969624922 0.00722960108167574 1.72066725479188 1 18.1 18 1 abnormal strial marginal cell morphology 0.000905334969624922 0.00722960108167574 1.72066725479188 1 18.1 18 1 decreased tidal volume 0.000905334969624922 0.00722960108167574 1.72066725479188 1 18.1 18 1 decreased DN2 thymocyte number 0.000905334969624922 0.00722960108167574 1.72066725479188 1 18.1 18 1 decreased sensitivity to skin irradiation 0.00670505795820338 0.0368592965105655 1.72066725479188 1 18.1 18 1 kinked vibrissae 0.00670505795820338 0.0368592965105655 1.72066725479188 1 18.1 18 1 abnormal respiratory sounds 0.00670505795820338 0.0368592965105655 1.72066725479188 1 18.1 18 1 abnormal type I pneumocyte morphology 0.00670505795820338 0.0368592965105655 1.72066725479188 1 18.1 18 1 improved righting response 0.00670505795820338 0.0368592965105655 1.72066725479188 1 18.1 18 1 gastric polyps 0.00670505795820338 0.0368592965105655 1.72066725479188 1 18.1 18 1 epidermal cyst 0.00670505795820338 0.0368592965105655 1.72066725479188 1 18.1 18 1 absent vas deferens 0.00670505795820338 0.0368592965105655 1.72066725479188 1 18.1 18 1 absent uterus 0.00670505795820338 0.0368592965105655 1.72066725479188 1 18.1 18 1 abnormal response to vitamins 0.00670505795820338 0.0368592965105655 1.72066725479188 1 18.1 18 1 abnormal inner cell mass proliferation 0.00670505795820338 0.0368592965105655 1.72066725479188 1 18.1 18 1 abnormal tail pigmentation 0.00670505795820338 0.0368592965105655 1.72066725479188 1 18.1 18 1 corneal deposits 0.00670505795820338 0.0368592965105655 1.72066725479188 1 18.1 18 1 abnormal optokinetic reflex 0.00670505795820338 0.0368592965105655 1.72066725479188 1 18.1 18 1 increased placenta apoptosis 0.00670505795820338 0.0368592965105655 1.72066725479188 1 18.1 18 1 decreased DN3 thymocyte number 0.00670505795820338 0.0368592965105655 1.72066725479188 1 18.1 18 1 increased response to stress-induced hyperthermia 0.00670505795820338 0.0368592965105655 1.72066725479188 1 18.1 18 1 aorta hypoplasia 0.00670505795820338 0.0368592965105655 1.72066725479188 1 18.1 18 1 decreased pre-pro B cell number 0.00670505795820338 0.0368592965105655 1.72066725479188 1 18.1 18 1 delayed optic fissure closure 0.00670505795820338 0.0368592965105655 1.72066725479188 1 18.1 18 1 decreased small intestinal villus height 0.00670505795820338 0.0368592965105655 1.72066725479188 1 18.1 18 1 decreased neuronal precursor proliferation 0.00670505795820338 0.0368592965105655 1.72066725479188 1 18.1 18 1 increased skin tumor incidence 7.1139965178122e-08 1.98957847816489e-06 1.63463389205229 0.95 18.1 18 1 increased hemangioma incidence 2.05334863528747e-05 0.000297825348704232 1.59776245087818 0.928571428571429 18.1 18 1 abnormal embryonic growth/weight/body size 0.000131287660398521 0.00144966643693429 1.57727831689256 0.916666666666667 18.1 18 1 dilated bile duct 0.000131287660398521 0.00144966643693429 1.57727831689256 0.916666666666667 18.1 18 1 abnormal rostral-caudal body axis extension 0.000131287660398521 0.00144966643693429 1.57727831689256 0.916666666666667 18.1 18 1 hematuria 0.000131287660398521 0.00144966643693429 1.57727831689256 0.916666666666667 18.1 18 1 prenatal growth retardation 0.000131287660398521 0.00144966643693429 1.57727831689256 0.916666666666667 18.1 18 1 decreased atrioventricular cushion size 0.000328956565314146 0.00317162579929821 1.56424295890171 0.909090909090909 18.1 18 1 impaired myelopoiesis 0.000328956565314146 0.00317162579929821 1.56424295890171 0.909090909090909 18.1 18 1 aorta dilation 0.000328956565314146 0.00317162579929821 1.56424295890171 0.909090909090909 18.1 18 1 abnormal respiratory mechanics 0.000818052258616614 0.00676048170534494 1.5486005293127 0.9 18.1 18 1 bifid ureter 0.000818052258616614 0.00676048170534494 1.5486005293127 0.9 18.1 18 1 abnormal hindlimb zeugopod morphology 0.000818052258616614 0.00676048170534494 1.5486005293127 0.9 18.1 18 1 increased circulating fructosamine level 0.000818052258616614 0.00676048170534494 1.5486005293127 0.9 18.1 18 1 abnormal heart and great artery attachment 0.000818052258616614 0.00676048170534494 1.5486005293127 0.9 18.1 18 1 fusion of atlas and odontoid process 0.000818052258616614 0.00676048170534494 1.5486005293127 0.9 18.1 18 1 abnormal adaptive thermogenesis 0.000818052258616614 0.00676048170534494 1.5486005293127 0.9 18.1 18 1 lethality during fetal growth through weaning, complete penetrance 0.000818052258616614 0.00676048170534494 1.5486005293127 0.9 18.1 18 1 decreased circulating lactate level 0.000818052258616614 0.00676048170534494 1.5486005293127 0.9 18.1 18 1 embryonic lethality between implantation and somite formation, incomplete penetrance 2.95754452273036e-06 5.4902179106655e-05 1.53954438586642 0.894736842105263 18.1 18 1 delayed kidney development 7.23215389254645e-06 0.000120738139649056 1.52948200425945 0.888888888888889 18.1 18 1 dilated uterus 0.00201606784391425 0.0138726660075704 1.52948200425945 0.888888888888889 18.1 18 1 decreased circulating bicarbonate level 0.00201606784391425 0.0138726660075704 1.52948200425945 0.888888888888889 18.1 18 1 liver hyperplasia 0.00201606784391425 0.0138726660075704 1.52948200425945 0.888888888888889 18.1 18 1 positive geotaxis 0.00201606784391425 0.0138726660075704 1.52948200425945 0.888888888888889 18.1 18 1 abnormal liver vasculature morphology 0.00201606784391425 0.0138726660075704 1.52948200425945 0.888888888888889 18.1 18 1 abnormal heart left ventricle pressure 0.00201606784391425 0.0138726660075704 1.52948200425945 0.888888888888889 18.1 18 1 increased myeloid cell number 0.00201606784391425 0.0138726660075704 1.52948200425945 0.888888888888889 18.1 18 1 increased cardiac muscle glycogen level 0.00201606784391425 0.0138726660075704 1.52948200425945 0.888888888888889 18.1 18 1 cerebellum atrophy 0.00201606784391425 0.0138726660075704 1.52948200425945 0.888888888888889 18.1 18 1 abnormal dorsal-ventral axis patterning 1.75767039910769e-05 0.00025947804853296 1.51823581305166 0.882352941176471 18.1 18 1 kidney cortex cysts 4.14382277074223e-09 1.44164463527571e-07 1.5055838479429 0.875 18.1 18 1 white spotting 4.24251697754918e-05 0.000556944264549768 1.5055838479429 0.875 18.1 18 1 abnormal erythrocyte cell number 0.00491417220207823 0.0286276425121068 1.5055838479429 0.875 18.1 18 1 coarse hair 0.00491417220207823 0.0286276425121068 1.5055838479429 0.875 18.1 18 1 colon polyps 0.00491417220207823 0.0286276425121068 1.5055838479429 0.875 18.1 18 1 liver cysts 0.00491417220207823 0.0286276425121068 1.5055838479429 0.875 18.1 18 1 abnormal eyelid aperture 0.00491417220207823 0.0286276425121068 1.5055838479429 0.875 18.1 18 1 binucleate 0.00491417220207823 0.0286276425121068 1.5055838479429 0.875 18.1 18 1 tau protein deposits 0.00491417220207823 0.0286276425121068 1.5055838479429 0.875 18.1 18 1 abnormal extraembryonic tissue physiology 0.00491417220207823 0.0286276425121068 1.5055838479429 0.875 18.1 18 1 abnormal kidney epithelium morphology 0.00491417220207823 0.0286276425121068 1.5055838479429 0.875 18.1 18 1 non-pigmented tail tip 0.00491417220207823 0.0286276425121068 1.5055838479429 0.875 18.1 18 1 abnormal cerebellum deep nucleus morphology 0.00491417220207823 0.0286276425121068 1.5055838479429 0.875 18.1 18 1 increased circulating ferritin level 0.00491417220207823 0.0286276425121068 1.5055838479429 0.875 18.1 18 1 increased cornea thickness 0.00491417220207823 0.0286276425121068 1.5055838479429 0.875 18.1 18 1 increased brain apoptosis 0.00491417220207823 0.0286276425121068 1.5055838479429 0.875 18.1 18 1 decreased basal metabolism 0.00491417220207823 0.0286276425121068 1.5055838479429 0.875 18.1 18 1 absent incisors 0.000101612834803646 0.00116738427092157 1.49124495415297 0.866666666666667 18.1 18 1 delayed intramembranous bone ossification 0.000101612834803646 0.00116738427092157 1.49124495415297 0.866666666666667 18.1 18 1 immune system phenotype 0.000101612834803646 0.00116738427092157 1.49124495415297 0.866666666666667 18.1 18 1 increased circulating phosphate level 5.82088345505212e-10 2.35438172267352e-08 1.48814465279298 0.864864864864865 18.1 18 1 split sternum 0.000241244789713689 0.00245438206303804 1.47485764696447 0.857142857142857 18.1 18 1 testis degeneration 0.000241244789713689 0.00245438206303804 1.47485764696447 0.857142857142857 18.1 18 1 maxilla hypoplasia 0.0118150463082367 0.0564106097730112 1.47485764696447 0.857142857142857 18.1 18 1 skin photosensitivity 0.0118150463082367 0.0564106097730112 1.47485764696447 0.857142857142857 18.1 18 1 excessive tearing 0.0118150463082367 0.0564106097730112 1.47485764696447 0.857142857142857 18.1 18 1 abnormal circulating alanine transaminase level 0.0118150463082367 0.0564106097730112 1.47485764696447 0.857142857142857 18.1 18 1 abnormal tumor incidence 0.0118150463082367 0.0564106097730112 1.47485764696447 0.857142857142857 18.1 18 1 abnormal gastrulation movements 0.0118150463082367 0.0564106097730112 1.47485764696447 0.857142857142857 18.1 18 1 decreased urine calcium level 0.0118150463082367 0.0564106097730112 1.47485764696447 0.857142857142857 18.1 18 1 decreased mortality induced by ionizing radiation 0.0118150463082367 0.0564106097730112 1.47485764696447 0.857142857142857 18.1 18 1 calcinosis 0.0118150463082367 0.0564106097730112 1.47485764696447 0.857142857142857 18.1 18 1 abnormal sinus venosus morphology 0.0118150463082367 0.0564106097730112 1.47485764696447 0.857142857142857 18.1 18 1 aorta coarctation 0.0118150463082367 0.0564106097730112 1.47485764696447 0.857142857142857 18.1 18 1 increased cell nucleus count 0.0118150463082367 0.0564106097730112 1.47485764696447 0.857142857142857 18.1 18 1 absent endocochlear potential 0.0118150463082367 0.0564106097730112 1.47485764696447 0.857142857142857 18.1 18 1 abnormal talus morphology 0.0118150463082367 0.0564106097730112 1.47485764696447 0.857142857142857 18.1 18 1 abnormal thyroid hormone level 0.0118150463082367 0.0564106097730112 1.47485764696447 0.857142857142857 18.1 18 1 abnormal spinal cord central canal morphology 0.0118150463082367 0.0564106097730112 1.47485764696447 0.857142857142857 18.1 18 1 abnormal cerebellum white matter morphology 0.0118150463082367 0.0564106097730112 1.47485764696447 0.857142857142857 18.1 18 1 decreased brain cholesterol level 0.0118150463082367 0.0564106097730112 1.47485764696447 0.857142857142857 18.1 18 1 coronary fistula 0.0118150463082367 0.0564106097730112 1.47485764696447 0.857142857142857 18.1 18 1 abnormal T wave 0.0118150463082367 0.0564106097730112 1.47485764696447 0.857142857142857 18.1 18 1 heart block 0.0118150463082367 0.0564106097730112 1.47485764696447 0.857142857142857 18.1 18 1 altered tumor pathology 0.0118150463082367 0.0564106097730112 1.47485764696447 0.857142857142857 18.1 18 1 dilated pulmonary alveolar ducts 0.0118150463082367 0.0564106097730112 1.47485764696447 0.857142857142857 18.1 18 1 increased compact bone volume 0.0118150463082367 0.0564106097730112 1.47485764696447 0.857142857142857 18.1 18 1 small lung lobe 0.0118150463082367 0.0564106097730112 1.47485764696447 0.857142857142857 18.1 18 1 parturition failure 0.0118150463082367 0.0564106097730112 1.47485764696447 0.857142857142857 18.1 18 1 decreased CD8-positive, naive alpha-beta T cell number 0.0118150463082367 0.0564106097730112 1.47485764696447 0.857142857142857 18.1 18 1 decreased areal bone mineral density 0.0118150463082367 0.0564106097730112 1.47485764696447 0.857142857142857 18.1 18 1 abnormal Mullerian duct topology 0.0118150463082367 0.0564106097730112 1.47485764696447 0.857142857142857 18.1 18 1 increased mammary adenocarcinoma incidence 1.29010385910986e-05 0.000196879346597288 1.4625671665731 0.85 18.1 18 1 absent ductus venosus valve 1.29010385910986e-05 0.000196879346597288 1.4625671665731 0.85 18.1 18 1 absent myocardial trabeculae 0.000567019593580365 0.00496641281348999 1.45594921559313 0.846153846153846 18.1 18 1 short hair 0.000567019593580365 0.00496641281348999 1.45594921559313 0.846153846153846 18.1 18 1 empty decidua capsularis 0.000567019593580365 0.00496641281348999 1.45594921559313 0.846153846153846 18.1 18 1 increased liver adenoma incidence 3.00300705315657e-05 0.000410438463995987 1.44898295140369 0.842105263157895 18.1 18 1 abnormal eyelid morphology 9.46666569186379e-08 2.54302658774099e-06 1.44314027821255 0.838709677419355 18.1 18 1 myocarditis 0.00131730108989227 0.00990472244331698 1.43388937899324 0.833333333333333 18.1 18 1 increased papilloma incidence 0.00131730108989227 0.00990472244331698 1.43388937899324 0.833333333333333 18.1 18 1 increased growth rate 0.00131730108989227 0.00990472244331698 1.43388937899324 0.833333333333333 18.1 18 1 absent ovary 0.00131730108989227 0.00990472244331698 1.43388937899324 0.833333333333333 18.1 18 1 embryonic lethality between implantation and placentation, incomplete penetrance 0.00131730108989227 0.00990472244331698 1.43388937899324 0.833333333333333 18.1 18 1 arrest of tooth development 0.0279110219449443 0.109478026031598 1.43388937899324 0.833333333333333 18.1 18 1 hemoglobinuria 0.0279110219449443 0.109478026031598 1.43388937899324 0.833333333333333 18.1 18 1 abnormal lacrimal gland physiology 0.0279110219449443 0.109478026031598 1.43388937899324 0.833333333333333 18.1 18 1 increased embryo size 0.0279110219449443 0.109478026031598 1.43388937899324 0.833333333333333 18.1 18 1 delayed brain development 0.0279110219449443 0.109478026031598 1.43388937899324 0.833333333333333 18.1 18 1 non-obstructive hydrocephaly 0.0279110219449443 0.109478026031598 1.43388937899324 0.833333333333333 18.1 18 1 abnormal otolithic membrane morphology 0.0279110219449443 0.109478026031598 1.43388937899324 0.833333333333333 18.1 18 1 phenotypic reversion 0.0279110219449443 0.109478026031598 1.43388937899324 0.833333333333333 18.1 18 1 loss of hippocampal neurons 0.0279110219449443 0.109478026031598 1.43388937899324 0.833333333333333 18.1 18 1 decreased liver function 0.0279110219449443 0.109478026031598 1.43388937899324 0.833333333333333 18.1 18 1 abnormal metopic suture morphology 0.0279110219449443 0.109478026031598 1.43388937899324 0.833333333333333 18.1 18 1 matted coat 0.0279110219449443 0.109478026031598 1.43388937899324 0.833333333333333 18.1 18 1 abnormal cholesterol level 0.0279110219449443 0.109478026031598 1.43388937899324 0.833333333333333 18.1 18 1 absent cochlear nerve compound action potential 0.0279110219449443 0.109478026031598 1.43388937899324 0.833333333333333 18.1 18 1 absent parietal bone 0.0279110219449443 0.109478026031598 1.43388937899324 0.833333333333333 18.1 18 1 abnormal immature B cell morphology 0.0279110219449443 0.109478026031598 1.43388937899324 0.833333333333333 18.1 18 1 abnormal dermis papillary layer morphology 0.0279110219449443 0.109478026031598 1.43388937899324 0.833333333333333 18.1 18 1 abnormal eyelid development 0.0279110219449443 0.109478026031598 1.43388937899324 0.833333333333333 18.1 18 1 delayed chorioallantoic fusion 0.0279110219449443 0.109478026031598 1.43388937899324 0.833333333333333 18.1 18 1 increased urine uric acid level 0.0279110219449443 0.109478026031598 1.43388937899324 0.833333333333333 18.1 18 1 absent sperm mitochondrial sheath 0.0279110219449443 0.109478026031598 1.43388937899324 0.833333333333333 18.1 18 1 abnormal olfactory bulb layer morphology 0.0279110219449443 0.109478026031598 1.43388937899324 0.833333333333333 18.1 18 1 abnormal renal water reabsorbtion 0.0279110219449443 0.109478026031598 1.43388937899324 0.833333333333333 18.1 18 1 decreased DN1 thymic pro-T cell number 0.0279110219449443 0.109478026031598 1.43388937899324 0.833333333333333 18.1 18 1 abnormal synaptic dopamine release 0.0279110219449443 0.109478026031598 1.43388937899324 0.833333333333333 18.1 18 1 abnormal heart right ventricle outflow tract morphology 0.0279110219449443 0.109478026031598 1.43388937899324 0.833333333333333 18.1 18 1 abnormal intestinal enteroendocrine cell morphology 0.0279110219449443 0.109478026031598 1.43388937899324 0.833333333333333 18.1 18 1 abnormal kidney collecting duct epithelium morphology 0.0279110219449443 0.109478026031598 1.43388937899324 0.833333333333333 18.1 18 1 thymus cortex atrophy 0.0279110219449443 0.109478026031598 1.43388937899324 0.833333333333333 18.1 18 1 abnormal vertebral artery origin 0.0279110219449443 0.109478026031598 1.43388937899324 0.833333333333333 18.1 18 1 increased cardiac cell glucose uptake 0.0279110219449443 0.109478026031598 1.43388937899324 0.833333333333333 18.1 18 1 abnormal neural tube closure 4.53682638413915e-18 6.44877464602637e-16 1.43043422386313 0.831325301204819 18.1 18 1 increased brain size 0.000158384676769427 0.00167651865303809 1.41702009218155 0.823529411764706 18.1 18 1 prolonged PR interval 1.97716526778434e-05 0.000287613953427692 1.40781866301154 0.818181818181818 18.1 18 1 increased mammary gland tumor incidence 1.97716526778434e-05 0.000287613953427692 1.40781866301154 0.818181818181818 18.1 18 1 abnormal proximal-distal axis patterning 0.00301898287847771 0.0190844216269715 1.40781866301154 0.818181818181818 18.1 18 1 fatigue 0.00301898287847771 0.0190844216269715 1.40781866301154 0.818181818181818 18.1 18 1 abnormal palate development 0.00301898287847771 0.0190844216269715 1.40781866301154 0.818181818181818 18.1 18 1 palatal shelf hypoplasia 0.00301898287847771 0.0190844216269715 1.40781866301154 0.818181818181818 18.1 18 1 common atrioventricular valve 0.00301898287847771 0.0190844216269715 1.40781866301154 0.818181818181818 18.1 18 1 decreased embryonic cilium length 0.00301898287847771 0.0190844216269715 1.40781866301154 0.818181818181818 18.1 18 1 chylous ascites 0.00301898287847771 0.0190844216269715 1.40781866301154 0.818181818181818 18.1 18 1 reduced sympathetic cervical ganglion size 0.00301898287847771 0.0190844216269715 1.40781866301154 0.818181818181818 18.1 18 1 vasculature congestion 0.000358092716592318 0.00339983065848622 1.39804214451841 0.8125 18.1 18 1 abnormal hair follicle orientation 0.000358092716592318 0.00339983065848622 1.39804214451841 0.8125 18.1 18 1 decreased creatinine clearance 0.000358092716592318 0.00339983065848622 1.39804214451841 0.8125 18.1 18 1 liver degeneration 4.43586593371223e-05 0.000570243747292463 1.392921111022 0.80952380952381 18.1 18 1 increased thymocyte apoptosis 5.6353467390519e-06 9.60131850232302e-05 1.38976970579344 0.807692307692308 18.1 18 1 reduced long term depression 9.50759689085072e-08 2.54302658774099e-06 1.38609306636013 0.805555555555556 18.1 18 1 abnormal retinal blood vessel morphology 9.50759689085072e-08 2.54302658774099e-06 1.38609306636013 0.805555555555556 18.1 18 1 abnormal cell differentiation 1.25257365384329e-08 4.09970653149367e-07 1.38492730263737 0.804878048780488 18.1 18 1 abnormal myocardial trabeculae morphology 3.65512036189911e-09 1.28966126244312e-07 1.37653380383351 0.8 18.1 18 1 increased B cell derived lymphoma incidence 4.86714541793574e-10 2.03479398775044e-08 1.37653380383351 0.8 18.1 18 1 abnormal egg cylinder morphology 1.24775646161863e-05 0.000192782248340146 1.37653380383351 0.8 18.1 18 1 vagina atresia 0.000799772609353858 0.00672106204651258 1.37653380383351 0.8 18.1 18 1 audiogenic seizures 0.000799772609353858 0.00672106204651258 1.37653380383351 0.8 18.1 18 1 abnormal pericyte morphology 0.000799772609353858 0.00672106204651258 1.37653380383351 0.8 18.1 18 1 abnormal energy homeostasis 0.000799772609353858 0.00672106204651258 1.37653380383351 0.8 18.1 18 1 anencephaly 9.85461982934339e-05 0.0011401565965345 1.37653380383351 0.8 18.1 18 1 abnormal optic stalk morphology 9.85461982934339e-05 0.0011401565965345 1.37653380383351 0.8 18.1 18 1 ketoaciduria 0.0068081301851048 0.0369764712564371 1.37653380383351 0.8 18.1 18 1 abnormal PNS synaptic transmission 0.0068081301851048 0.0369764712564371 1.37653380383351 0.8 18.1 18 1 impaired basement membrane formation 0.0068081301851048 0.0369764712564371 1.37653380383351 0.8 18.1 18 1 aneurysm 0.0068081301851048 0.0369764712564371 1.37653380383351 0.8 18.1 18 1 abnormal ear physiology 0.0068081301851048 0.0369764712564371 1.37653380383351 0.8 18.1 18 1 abnormal gas homeostasis 0.0068081301851048 0.0369764712564371 1.37653380383351 0.8 18.1 18 1 abnormal respiratory conducting tube morphology 0.0068081301851048 0.0369764712564371 1.37653380383351 0.8 18.1 18 1 osteosclerosis 0.0068081301851048 0.0369764712564371 1.37653380383351 0.8 18.1 18 1 increased serotonin level 0.0068081301851048 0.0369764712564371 1.37653380383351 0.8 18.1 18 1 abnormal vibrissa follicle morphology 0.0068081301851048 0.0369764712564371 1.37653380383351 0.8 18.1 18 1 abnormal left subclavian artery morphology 0.0068081301851048 0.0369764712564371 1.37653380383351 0.8 18.1 18 1 small superior vagus ganglion 0.000216559644304342 0.00223523699256037 1.35842151694096 0.789473684210526 18.1 18 1 enlarged pericardium 9.99619976522445e-07 2.05500387735503e-05 1.35567723104815 0.787878787878788 18.1 18 1 abnormal reproductive system morphology 3.77193310241277e-08 1.1236746817068e-06 1.35195284305077 0.785714285714286 18.1 18 1 abnormal ventral body wall morphology 0.00176152720775818 0.0124130281283243 1.35195284305077 0.785714285714286 18.1 18 1 lysosomal protein accumulation 0.00176152720775818 0.0124130281283243 1.35195284305077 0.785714285714286 18.1 18 1 abnormal viscerocranium morphology 0.00176152720775818 0.0124130281283243 1.35195284305077 0.785714285714286 18.1 18 1 abnormal renal reabsorbtion 0.00176152720775818 0.0124130281283243 1.35195284305077 0.785714285714286 18.1 18 1 multiple persisting craniopharyngeal ducts 0.00176152720775818 0.0124130281283243 1.35195284305077 0.785714285714286 18.1 18 1 abnormal branching of the mammary ductal tree 2.84427427283075e-07 6.77046148676219e-06 1.34863109159364 0.783783783783784 18.1 18 1 decreased width of hypertrophic chondrocyte zone 2.84427427283075e-07 6.77046148676219e-06 1.34863109159364 0.783783783783784 18.1 18 1 microcephaly 2.22728930457484e-12 1.38509553628248e-10 1.34660915592408 0.782608695652174 18.1 18 1 abnormal hematopoietic stem cell physiology 5.95065529920992e-05 0.000738267085126417 1.34660915592408 0.782608695652174 18.1 18 1 abnormal mammary gland development 8.1162430432362e-08 2.23084580884531e-06 1.34295980861806 0.780487804878049 18.1 18 1 short stride length 3.11679726588661e-09 1.10757617127042e-07 1.34212045873767 0.78 18.1 18 1 underdeveloped hair follicles 0.00047018295476937 0.0042329904829758 1.33829675372702 0.777777777777778 18.1 18 1 abnormal bile duct morphology 0.00047018295476937 0.0042329904829758 1.33829675372702 0.777777777777778 18.1 18 1 acidosis 0.00047018295476937 0.0042329904829758 1.33829675372702 0.777777777777778 18.1 18 1 abnormal metacarpal bone morphology 0.00047018295476937 0.0042329904829758 1.33829675372702 0.777777777777778 18.1 18 1 abnormal body wall morphology 0.00047018295476937 0.0042329904829758 1.33829675372702 0.777777777777778 18.1 18 1 absent inner cell mass 0.00047018295476937 0.0042329904829758 1.33829675372702 0.777777777777778 18.1 18 1 increased gastrointestinal tumor incidence 0.00047018295476937 0.0042329904829758 1.33829675372702 0.777777777777778 18.1 18 1 increased effector memory CD8-positive, alpha-beta T cell number 0.00047018295476937 0.0042329904829758 1.33829675372702 0.777777777777778 18.1 18 1 abnormal aerobic respiration 0.00047018295476937 0.0042329904829758 1.33829675372702 0.777777777777778 18.1 18 1 heart hyperplasia 0.0150575374556521 0.0689155923108275 1.33829675372702 0.777777777777778 18.1 18 1 distorted hair follicle pattern 0.0150575374556521 0.0689155923108275 1.33829675372702 0.777777777777778 18.1 18 1 abnormal head movements 0.0150575374556521 0.0689155923108275 1.33829675372702 0.777777777777778 18.1 18 1 abnormal geniculate ganglion morphology 0.0150575374556521 0.0689155923108275 1.33829675372702 0.777777777777778 18.1 18 1 abnormal lens vesicle development 0.0150575374556521 0.0689155923108275 1.33829675372702 0.777777777777778 18.1 18 1 decreased level of surface class I molecules 0.0150575374556521 0.0689155923108275 1.33829675372702 0.777777777777778 18.1 18 1 polycythemia 0.0150575374556521 0.0689155923108275 1.33829675372702 0.777777777777778 18.1 18 1 pancreas cysts 0.0150575374556521 0.0689155923108275 1.33829675372702 0.777777777777778 18.1 18 1 premature bone ossification 0.0150575374556521 0.0689155923108275 1.33829675372702 0.777777777777778 18.1 18 1 decreased fear-related response 0.0150575374556521 0.0689155923108275 1.33829675372702 0.777777777777778 18.1 18 1 decreased cochlear hair cell number 0.0150575374556521 0.0689155923108275 1.33829675372702 0.777777777777778 18.1 18 1 abnormal gallbladder physiology 0.0150575374556521 0.0689155923108275 1.33829675372702 0.777777777777778 18.1 18 1 abnormal posterior eye segment morphology 0.0150575374556521 0.0689155923108275 1.33829675372702 0.777777777777778 18.1 18 1 abnormal cerebellar layer morphology 0.0150575374556521 0.0689155923108275 1.33829675372702 0.777777777777778 18.1 18 1 abnormal telomere morphology 0.0150575374556521 0.0689155923108275 1.33829675372702 0.777777777777778 18.1 18 1 prolonged RR interval 0.0150575374556521 0.0689155923108275 1.33829675372702 0.777777777777778 18.1 18 1 shortened ST segment 0.0150575374556521 0.0689155923108275 1.33829675372702 0.777777777777778 18.1 18 1 iris coloboma 0.0150575374556521 0.0689155923108275 1.33829675372702 0.777777777777778 18.1 18 1 fusion of atlas and occipital bones 0.0150575374556521 0.0689155923108275 1.33829675372702 0.777777777777778 18.1 18 1 abnormal pulmonary alveolar system morphology 0.0150575374556521 0.0689155923108275 1.33829675372702 0.777777777777778 18.1 18 1 abnormal lung lobe morphology 0.0150575374556521 0.0689155923108275 1.33829675372702 0.777777777777778 18.1 18 1 trigeminal neuroma 0.0150575374556521 0.0689155923108275 1.33829675372702 0.777777777777778 18.1 18 1 abnormal ductus venosus valve topology 0.0150575374556521 0.0689155923108275 1.33829675372702 0.777777777777778 18.1 18 1 abnormal infrahyoid muscle connection 0.0150575374556521 0.0689155923108275 1.33829675372702 0.777777777777778 18.1 18 1 symmetric azygos veins 0.0150575374556521 0.0689155923108275 1.33829675372702 0.777777777777778 18.1 18 1 decreased platelet dense granule number 0.0150575374556521 0.0689155923108275 1.33829675372702 0.777777777777778 18.1 18 1 pale kidney 4.6248305393896e-06 8.09052865460641e-05 1.33212948758081 0.774193548387097 18.1 18 1 preaxial polydactyly 4.6248305393896e-06 8.09052865460641e-05 1.33212948758081 0.774193548387097 18.1 18 1 abnormal cell cycle 6.34525575265541e-19 1.12741597748074e-16 1.33164683196937 0.773913043478261 18.1 18 1 enlarged kidney 1.91148521510489e-09 6.9413422957276e-08 1.33108221597108 0.773584905660377 18.1 18 1 abnormal astrocyte morphology 4.94565497931196e-08 1.43314500351615e-06 1.32960651506646 0.772727272727273 18.1 18 1 abnormal germ layer development 0.00012795448197867 0.00143696060461373 1.32960651506646 0.772727272727273 18.1 18 1 abnormal vascular branching morphogenesis 0.00012795448197867 0.00143696060461373 1.32960651506646 0.772727272727273 18.1 18 1 abnormal liver development 1.30234821265e-06 2.56094164345207e-05 1.32737188226802 0.771428571428571 18.1 18 1 pale yolk sac 7.19266532483857e-14 5.50515538324183e-12 1.32677956996001 0.771084337349398 18.1 18 1 kidney cysts 1.80816772058471e-12 1.15328646280884e-10 1.32537883139375 0.77027027027027 18.1 18 1 liver hypoplasia 4.04847859968257e-09 1.41839303052259e-07 1.32359019599376 0.769230769230769 18.1 18 1 failure of heart looping 3.68527266730391e-07 8.64822241501742e-06 1.32359019599376 0.769230769230769 18.1 18 1 heart inflammation 3.52849575399677e-05 0.000471888881078869 1.32359019599376 0.769230769230769 18.1 18 1 absent teeth 0.00381823941093198 0.0237743943296453 1.32359019599376 0.769230769230769 18.1 18 1 increased foot pad pigmentation 0.00381823941093198 0.0237743943296453 1.32359019599376 0.769230769230769 18.1 18 1 muscle fatigue 0.00381823941093198 0.0237743943296453 1.32359019599376 0.769230769230769 18.1 18 1 increased circulating thyroxine level 0.00381823941093198 0.0237743943296453 1.32359019599376 0.769230769230769 18.1 18 1 decreased cardiac stroke volume 0.00381823941093198 0.0237743943296453 1.32359019599376 0.769230769230769 18.1 18 1 absent hypoglossal nerve 0.00381823941093198 0.0237743943296453 1.32359019599376 0.769230769230769 18.1 18 1 kidney failure 1.04694942700797e-07 2.78533336864419e-06 1.32051207925889 0.767441860465116 18.1 18 1 abnormal heart tube morphology 9.82410240237737e-06 0.000157154049684333 1.31917822867378 0.766666666666667 18.1 18 1 abnormal adipose tissue morphology 0.00100714384601671 0.00795323910148113 1.31580437131144 0.764705882352941 18.1 18 1 abnormal bone marrow cavity morphology 0.00100714384601671 0.00795323910148113 1.31580437131144 0.764705882352941 18.1 18 1 nephrocalcinosis 0.00100714384601671 0.00795323910148113 1.31580437131144 0.764705882352941 18.1 18 1 abnormal embryonic-extraembryonic boundary morphology 0.00100714384601671 0.00795323910148113 1.31580437131144 0.764705882352941 18.1 18 1 abnormal melanosome morphology 0.00100714384601671 0.00795323910148113 1.31580437131144 0.764705882352941 18.1 18 1 coloboma 0.00100714384601671 0.00795323910148113 1.31580437131144 0.764705882352941 18.1 18 1 abnormal forebrain development 8.00180570311661e-12 4.52374811056876e-10 1.31439859741047 0.763888888888889 18.1 18 1 abnormal embryo turning 2.44283973437159e-09 8.80661425978163e-08 1.31396408547744 0.763636363636364 18.1 18 1 abnormal eye pigmentation 0.000271946322953632 0.00266850681793751 1.31098457507953 0.761904761904762 18.1 18 1 increased incidence of induced tumors 0.000271946322953632 0.00266850681793751 1.31098457507953 0.761904761904762 18.1 18 1 failure to gastrulate 6.26164344000719e-08 1.7699815973884e-06 1.3092033460373 0.760869565217391 18.1 18 1 abnormal keratinocyte physiology 7.45777905377335e-05 0.000900544922148602 1.30770711364183 0.76 18.1 18 1 decreased trophoblast giant cell number 2.06785379345123e-05 0.000299057343674996 1.30533377949729 0.758620689655172 18.1 18 1 belly spot 5.7809023119307e-06 9.81569590507005e-05 1.30353579908476 0.757575757575758 18.1 18 1 embryonic lethality between somite formation and embryo turning, complete penetrance 3.48298328861438e-11 1.76814712865883e-09 1.30279092148528 0.757142857142857 18.1 18 1 trabecula carnea hypoplasia 1.30559814751782e-07 3.41860567573745e-06 1.30005970362053 0.755555555555556 18.1 18 1 increased T cell derived lymphoma incidence 3.71911152596348e-08 1.11461324347399e-06 1.29927935565918 0.755102040816326 18.1 18 1 abnormal extraembryonic tissue morphology 1.7044624063502e-15 1.54176372210768e-13 1.29893508449976 0.754901960784314 18.1 18 1 anophthalmia 1.44960116036098e-13 1.05426921043975e-11 1.29533377607928 0.752808988764045 18.1 18 1 decreased mean corpuscular hemoglobin 1.4895962463164e-10 6.84796843772608e-09 1.29050044109391 0.75 18.1 18 1 small heart 7.6957824357639e-08 2.13891159876678e-06 1.29050044109391 0.75 18.1 18 1 polydipsia 1.20231659840578e-05 0.000186922658658399 1.29050044109391 0.75 18.1 18 1 bradykinesia 1.20231659840578e-05 0.000186922658658399 1.29050044109391 0.75 18.1 18 1 pancreatic islet hyperplasia 1.20231659840578e-05 0.000186922658658399 1.29050044109391 0.75 18.1 18 1 ocular hypertelorism 0.000155881355456323 0.00165353889849725 1.29050044109391 0.75 18.1 18 1 abnormal nursing 0.000155881355456323 0.00165353889849725 1.29050044109391 0.75 18.1 18 1 blindness 0.000155881355456323 0.00165353889849725 1.29050044109391 0.75 18.1 18 1 poor circulation 0.0021248122876385 0.0144807412753445 1.29050044109391 0.75 18.1 18 1 disorganized yolk sac vascular plexus 0.0021248122876385 0.0144807412753445 1.29050044109391 0.75 18.1 18 1 intraventricular hemorrhage 0.0021248122876385 0.0144807412753445 1.29050044109391 0.75 18.1 18 1 decreased circulating triiodothyronine level 0.0021248122876385 0.0144807412753445 1.29050044109391 0.75 18.1 18 1 abnormal mineral level 0.00812402824423404 0.0427693550423961 1.29050044109391 0.75 18.1 18 1 mesocardia 0.00812402824423404 0.0427693550423961 1.29050044109391 0.75 18.1 18 1 abnormal thymus involution 0.00812402824423404 0.0427693550423961 1.29050044109391 0.75 18.1 18 1 abnormal respiratory function 0.00812402824423404 0.0427693550423961 1.29050044109391 0.75 18.1 18 1 increased circulating parathyroid hormone level 0.00812402824423404 0.0427693550423961 1.29050044109391 0.75 18.1 18 1 loss of dopaminergic neurons 0.00812402824423404 0.0427693550423961 1.29050044109391 0.75 18.1 18 1 abnormal vascular endothelial cell development 0.00812402824423404 0.0427693550423961 1.29050044109391 0.75 18.1 18 1 absent cochlear hair cells 0.00812402824423404 0.0427693550423961 1.29050044109391 0.75 18.1 18 1 abnormal fatty acid level 0.00812402824423404 0.0427693550423961 1.29050044109391 0.75 18.1 18 1 decreased renal glomerular filtration rate 0.00812402824423404 0.0427693550423961 1.29050044109391 0.75 18.1 18 1 decreased red blood cell distribution width 0.00812402824423404 0.0427693550423961 1.29050044109391 0.75 18.1 18 1 decreased mammary gland epithelial cell proliferation 0.00812402824423404 0.0427693550423961 1.29050044109391 0.75 18.1 18 1 abnormal pulmonary valve cusp morphology 0.00812402824423404 0.0427693550423961 1.29050044109391 0.75 18.1 18 1 abnormal exoccipital bone morphology 0.0325176686267122 0.119391440160807 1.29050044109391 0.75 18.1 18 1 failure of vascular branching 0.0325176686267122 0.119391440160807 1.29050044109391 0.75 18.1 18 1 pointed snout 0.0325176686267122 0.119391440160807 1.29050044109391 0.75 18.1 18 1 clubfoot 0.0325176686267122 0.119391440160807 1.29050044109391 0.75 18.1 18 1 enlarged pituitary gland 0.0325176686267122 0.119391440160807 1.29050044109391 0.75 18.1 18 1 abnormal vagus ganglion morphology 0.0325176686267122 0.119391440160807 1.29050044109391 0.75 18.1 18 1 abnormal pupil morphology 0.0325176686267122 0.119391440160807 1.29050044109391 0.75 18.1 18 1 absent eyelids 0.0325176686267122 0.119391440160807 1.29050044109391 0.75 18.1 18 1 spinning 0.0325176686267122 0.119391440160807 1.29050044109391 0.75 18.1 18 1 preneoplasia 0.0325176686267122 0.119391440160807 1.29050044109391 0.75 18.1 18 1 abnormal hepatobiliary system morphology 0.0325176686267122 0.119391440160807 1.29050044109391 0.75 18.1 18 1 abnormal thyroid physiology 0.0325176686267122 0.119391440160807 1.29050044109391 0.75 18.1 18 1 head spot 0.0325176686267122 0.119391440160807 1.29050044109391 0.75 18.1 18 1 short ureter 0.0325176686267122 0.119391440160807 1.29050044109391 0.75 18.1 18 1 hypospadia 0.0325176686267122 0.119391440160807 1.29050044109391 0.75 18.1 18 1 early eyelid opening 0.0325176686267122 0.119391440160807 1.29050044109391 0.75 18.1 18 1 abnormal soft palate morphology 0.0325176686267122 0.119391440160807 1.29050044109391 0.75 18.1 18 1 calcified muscle 0.0325176686267122 0.119391440160807 1.29050044109391 0.75 18.1 18 1 abnormal neuron apoptosis 0.0325176686267122 0.119391440160807 1.29050044109391 0.75 18.1 18 1 abnormal perineum morphology 0.0325176686267122 0.119391440160807 1.29050044109391 0.75 18.1 18 1 increased left ventricle systolic pressure 0.0325176686267122 0.119391440160807 1.29050044109391 0.75 18.1 18 1 abnormal forelimb zeugopod morphology 0.0325176686267122 0.119391440160807 1.29050044109391 0.75 18.1 18 1 accumulation of giant lysosomes in kidney/renal tubule cells 0.0325176686267122 0.119391440160807 1.29050044109391 0.75 18.1 18 1 abnormal choroid pigmentation 0.0325176686267122 0.119391440160807 1.29050044109391 0.75 18.1 18 1 Sertoli cell hypoplasia 0.0325176686267122 0.119391440160807 1.29050044109391 0.75 18.1 18 1 craniofacial phenotype 0.0325176686267122 0.119391440160807 1.29050044109391 0.75 18.1 18 1 abnormal sphingomyelin level 0.0325176686267122 0.119391440160807 1.29050044109391 0.75 18.1 18 1 abnormal olfactory bulb mitral cell layer morphology 0.0325176686267122 0.119391440160807 1.29050044109391 0.75 18.1 18 1 decreased hippocampus pyramidal cell number 0.0325176686267122 0.119391440160807 1.29050044109391 0.75 18.1 18 1 pleural effusion 0.0325176686267122 0.119391440160807 1.29050044109391 0.75 18.1 18 1 myocardial trabeculae hypoplasia 0.0325176686267122 0.119391440160807 1.29050044109391 0.75 18.1 18 1 abnormal stomach position or orientation 0.0325176686267122 0.119391440160807 1.29050044109391 0.75 18.1 18 1 lung situs inversus 0.0325176686267122 0.119391440160807 1.29050044109391 0.75 18.1 18 1 abnormal anterior commissure pars posterior morphology 0.0325176686267122 0.119391440160807 1.29050044109391 0.75 18.1 18 1 abnormal maxillary prominence morphology 0.0325176686267122 0.119391440160807 1.29050044109391 0.75 18.1 18 1 abnormal macrophage activation involved in immune response 0.0325176686267122 0.119391440160807 1.29050044109391 0.75 18.1 18 1 lethality during fetal growth through weaning, incomplete penetrance 0.0325176686267122 0.119391440160807 1.29050044109391 0.75 18.1 18 1 impaired neuron differentiation 0.0325176686267122 0.119391440160807 1.29050044109391 0.75 18.1 18 1 decreased cranium length 0.0325176686267122 0.119391440160807 1.29050044109391 0.75 18.1 18 1 abnormal heart echocardiography feature 0.0325176686267122 0.119391440160807 1.29050044109391 0.75 18.1 18 1 prolonged PQ interval 0.0325176686267122 0.119391440160807 1.29050044109391 0.75 18.1 18 1 absent hypoglossal canal 0.0325176686267122 0.119391440160807 1.29050044109391 0.75 18.1 18 1 abnormal umbilical vein topology 0.0325176686267122 0.119391440160807 1.29050044109391 0.75 18.1 18 1 decreased white adipose tissue mass 0.0325176686267122 0.119391440160807 1.29050044109391 0.75 18.1 18 1 decreased vascular endothelial cell proliferation 0.0325176686267122 0.119391440160807 1.29050044109391 0.75 18.1 18 1 renal interstitial fibrosis 2.70410121423828e-07 6.4989872177949e-06 1.29050044109391 0.75 18.1 18 1 decreased blood urea nitrogen level 2.70410121423828e-07 6.4989872177949e-06 1.29050044109391 0.75 18.1 18 1 lymphoid hyperplasia 4.31002094174192e-05 0.000556944264549768 1.29050044109391 0.75 18.1 18 1 small superior cervical ganglion 4.31002094174192e-05 0.000556944264549768 1.29050044109391 0.75 18.1 18 1 abnormal somite shape 4.31002094174192e-05 0.000556944264549768 1.29050044109391 0.75 18.1 18 1 increased triglyceride level 4.31002094174192e-05 0.000556944264549768 1.29050044109391 0.75 18.1 18 1 abnormal renal tubule epithelium morphology 4.31002094174192e-05 0.000556944264549768 1.29050044109391 0.75 18.1 18 1 abnormal mitotic spindle morphology 4.31002094174192e-05 0.000556944264549768 1.29050044109391 0.75 18.1 18 1 prolonged QRS complex duration 4.31002094174192e-05 0.000556944264549768 1.29050044109391 0.75 18.1 18 1 subcutaneous edema 4.31002094174192e-05 0.000556944264549768 1.29050044109391 0.75 18.1 18 1 abnormal neuron proliferation 0.000570599982337062 0.00498898930075023 1.29050044109391 0.75 18.1 18 1 decreased embryo size 1.87305944461926e-65 2.32961768424521e-62 1.28870057994873 0.748953974895398 18.1 18 1 abnormal head morphology 1.2915053919903e-08 4.17223332802061e-07 1.2826792262994 0.745454545454545 18.1 18 1 increased cellular sensitivity to gamma-irradiation 1.58215084937741e-07 3.95537712344353e-06 1.28134795569608 0.74468085106383 18.1 18 1 abnormal cell nucleus morphology 1.58215084937741e-07 3.95537712344353e-06 1.28134795569608 0.74468085106383 18.1 18 1 increased embryonic tissue cell apoptosis 1.50033951071361e-11 8.11324898456544e-10 1.27947052279396 0.743589743589744 18.1 18 1 lethality throughout fetal growth and development, incomplete penetrance 1.38475080190945e-24 3.87920959658846e-22 1.27848460830905 0.743016759776536 18.1 18 1 abnormal midbrain development 6.95231760994242e-06 0.000116457172085736 1.27820996070254 0.742857142857143 18.1 18 1 decreased glycogen level 6.95231760994242e-06 0.000116457172085736 1.27820996070254 0.742857142857143 18.1 18 1 abnormal object recognition memory 2.47720090084672e-05 0.000349123922994686 1.27662409226495 0.741935483870968 18.1 18 1 abnormal postnatal growth/weight/body size 2.47720090084672e-05 0.000349123922994686 1.27662409226495 0.741935483870968 18.1 18 1 abnormal mitochondrial ATP synthesis coupled electron transport 2.47720090084672e-05 0.000349123922994686 1.27662409226495 0.741935483870968 18.1 18 1 abnormal embryonic neuroepithelium morphology 7.5646883564338e-09 2.57769346392179e-07 1.27566710269053 0.741379310344828 18.1 18 1 increased neuron apoptosis 8.83157799067636e-12 4.93675286557471e-10 1.27456833688288 0.740740740740741 18.1 18 1 decreased bone ossification 8.88873194213125e-05 0.00103563094641927 1.27456833688288 0.740740740740741 18.1 18 1 abnormal Wolffian duct morphology 0.000321890280773955 0.00312164551042968 1.27179753615052 0.739130434782609 18.1 18 1 lethality throughout fetal growth and development, complete penetrance 3.41968861604205e-25 1.2152107760578e-22 1.26786008247823 0.736842105263158 18.1 18 1 decreased hair follicle number 4.00437780311728e-06 7.19197818429909e-05 1.26786008247823 0.736842105263158 18.1 18 1 persistence of hyaloid vascular system 4.00437780311728e-06 7.19197818429909e-05 1.26786008247823 0.736842105263158 18.1 18 1 kyphoscoliosis 0.00118032822407145 0.00907593959003938 1.26786008247823 0.736842105263158 18.1 18 1 irregular coat pigmentation 0.00118032822407145 0.00907593959003938 1.26786008247823 0.736842105263158 18.1 18 1 decreased germ cell number 0.00118032822407145 0.00907593959003938 1.26786008247823 0.736842105263158 18.1 18 1 abnormal metatarsal bone morphology 0.00118032822407145 0.00907593959003938 1.26786008247823 0.736842105263158 18.1 18 1 increased liver cholesterol level 0.00118032822407145 0.00907593959003938 1.26786008247823 0.736842105263158 18.1 18 1 decreased circulating magnesium level 0.00118032822407145 0.00907593959003938 1.26786008247823 0.736842105263158 18.1 18 1 increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 0.00118032822407145 0.00907593959003938 1.26786008247823 0.736842105263158 18.1 18 1 shortened RR interval 0.00118032822407145 0.00907593959003938 1.26786008247823 0.736842105263158 18.1 18 1 incomplete embryo turning 1.53677180374076e-08 4.87153404792049e-07 1.26786008247823 0.736842105263158 18.1 18 1 embryonic lethality before implantation, complete penetrance 5.31958621784524e-17 6.4548637643366e-15 1.26641109952683 0.736 18.1 18 1 abnormal mesoderm development 5.3563820476324e-08 1.54034686051857e-06 1.26615137616761 0.735849056603774 18.1 18 1 impaired balance 4.35323727606788e-14 3.38396178881839e-12 1.26519651087639 0.735294117647059 18.1 18 1 enlarged liver sinusoidal spaces 1.41856379388507e-05 0.000212817825293747 1.26519651087639 0.735294117647059 18.1 18 1 abnormal brown adipose tissue morphology 1.41856379388507e-05 0.000212817825293747 1.26519651087639 0.735294117647059 18.1 18 1 polydactyly 1.49816641956367e-13 1.06476827676133e-11 1.26416369739812 0.73469387755102 18.1 18 1 abnormal erythropoiesis 2.54912546110491e-14 2.07899986376999e-12 1.26182265351405 0.733333333333333 18.1 18 1 abnormal kidney development 8.9281894073463e-09 3.00119880415864e-07 1.26182265351405 0.733333333333333 18.1 18 1 abnormal brain vasculature morphology 5.05282356478829e-05 0.000638015158244207 1.26182265351405 0.733333333333333 18.1 18 1 macrocytosis 0.00440635235337004 0.0266362125856816 1.26182265351405 0.733333333333333 18.1 18 1 abnormal glial cell morphology 0.00440635235337004 0.0266362125856816 1.26182265351405 0.733333333333333 18.1 18 1 abnormal placenta size 0.00440635235337004 0.0266362125856816 1.26182265351405 0.733333333333333 18.1 18 1 abnormal trophectoderm morphology 0.00440635235337004 0.0266362125856816 1.26182265351405 0.733333333333333 18.1 18 1 abnormal dendritic cell morphology 0.00440635235337004 0.0266362125856816 1.26182265351405 0.733333333333333 18.1 18 1 abnormal cerebral aqueduct morphology 0.00440635235337004 0.0266362125856816 1.26182265351405 0.733333333333333 18.1 18 1 absent chorion 0.00440635235337004 0.0266362125856816 1.26182265351405 0.733333333333333 18.1 18 1 heterochrony 0.00440635235337004 0.0266362125856816 1.26182265351405 0.733333333333333 18.1 18 1 decreased brown adipose tissue mass 0.00440635235337004 0.0266362125856816 1.26182265351405 0.733333333333333 18.1 18 1 abnormal axon morphology 1.4902727505252e-14 1.23568448897715e-12 1.25863623267184 0.731481481481482 18.1 18 1 abnormal placenta vasculature 1.08062944460123e-07 2.85964440792081e-06 1.25741068619407 0.730769230769231 18.1 18 1 ventricular hypoplasia 0.000181229765817384 0.00188623030322486 1.25741068619407 0.730769230769231 18.1 18 1 increased leukemia incidence 0.000181229765817384 0.00188623030322486 1.25741068619407 0.730769230769231 18.1 18 1 abnormal Mullerian duct morphology 0.000181229765817384 0.00188623030322486 1.25741068619407 0.730769230769231 18.1 18 1 decreased bone resorption 0.000181229765817384 0.00188623030322486 1.25741068619407 0.730769230769231 18.1 18 1 abnormal nerve conduction 0.000181229765817384 0.00188623030322486 1.25741068619407 0.730769230769231 18.1 18 1 abnormal vitelline vasculature morphology 2.53564865472441e-15 2.25265215308106e-13 1.25683521219581 0.730434782608696 18.1 18 1 thymus atrophy 3.76984632653401e-07 8.76401190397509e-06 1.25465320661908 0.729166666666667 18.1 18 1 abnormal cell morphology 5.07147615413056e-15 4.27637184183043e-13 1.25276651006777 0.728070175438597 18.1 18 1 increased cardiomyocyte apoptosis 2.86692024430634e-05 0.000395094964416179 1.25139436712137 0.727272727272727 18.1 18 1 abnormal amino acid level 1.31807861644953e-06 2.58166973103795e-05 1.25139436712137 0.727272727272727 18.1 18 1 abnormal facial nerve morphology 0.000655924565553532 0.00563596669020522 1.25139436712137 0.727272727272727 18.1 18 1 abnormal tail movements 0.000655924565553532 0.00563596669020522 1.25139436712137 0.727272727272727 18.1 18 1 abnormal lysosome physiology 0.000655924565553532 0.00563596669020522 1.25139436712137 0.727272727272727 18.1 18 1 abnormal basement membrane morphology 0.000655924565553532 0.00563596669020522 1.25139436712137 0.727272727272727 18.1 18 1 abnormal sperm midpiece morphology 0.000655924565553532 0.00563596669020522 1.25139436712137 0.727272727272727 18.1 18 1 premature suture closure 0.0169125230027771 0.0754617057747228 1.25139436712137 0.727272727272727 18.1 18 1 abnormal awl hair morphology 0.0169125230027771 0.0754617057747228 1.25139436712137 0.727272727272727 18.1 18 1 abnormal stomach epithelium morphology 0.0169125230027771 0.0754617057747228 1.25139436712137 0.727272727272727 18.1 18 1 delayed hepatic development 0.0169125230027771 0.0754617057747228 1.25139436712137 0.727272727272727 18.1 18 1 abnormal eye distance/ position 0.0169125230027771 0.0754617057747228 1.25139436712137 0.727272727272727 18.1 18 1 abnormal hemoglobin 0.0169125230027771 0.0754617057747228 1.25139436712137 0.727272727272727 18.1 18 1 abnormal fear/anxiety-related behavior 0.0169125230027771 0.0754617057747228 1.25139436712137 0.727272727272727 18.1 18 1 variable body spotting 0.0169125230027771 0.0754617057747228 1.25139436712137 0.727272727272727 18.1 18 1 patent ductus arteriosus 0.0169125230027771 0.0754617057747228 1.25139436712137 0.727272727272727 18.1 18 1 impaired luteinization 0.0169125230027771 0.0754617057747228 1.25139436712137 0.727272727272727 18.1 18 1 abnormal hair medulla 0.0169125230027771 0.0754617057747228 1.25139436712137 0.727272727272727 18.1 18 1 pharyngeal arch hypoplasia 0.0169125230027771 0.0754617057747228 1.25139436712137 0.727272727272727 18.1 18 1 increased glycogen level 0.0169125230027771 0.0754617057747228 1.25139436712137 0.727272727272727 18.1 18 1 embryonic lethality between implantation and somite formation, complete penetrance 2.33763251269329e-30 9.6914347922076e-28 1.2501174340937 0.726530612244898 18.1 18 1 failure of chorioallantoic fusion 2.16572907038102e-07 5.33391194314137e-06 1.2483272240647 0.725490196078431 18.1 18 1 decreased circulating phosphate level 4.62062506302434e-06 8.09052865460641e-05 1.24748375972412 0.725 18.1 18 1 abnormal sternum morphology 1.7299229100734e-09 6.32821064530525e-08 1.24686032955934 0.72463768115942 18.1 18 1 abnormal outer ear morphology 0.000101957097060051 0.00116738427092157 1.24600042588378 0.724137931034483 18.1 18 1 cortical renal glomerulopathies 0.00240324216325977 0.0162226998130494 1.2427041284608 0.722222222222222 18.1 18 1 decreased cellular sensitivity to gamma-irradiation 0.00240324216325977 0.0162226998130494 1.2427041284608 0.722222222222222 18.1 18 1 abnormal glycogen homeostasis 0.00240324216325977 0.0162226998130494 1.2427041284608 0.722222222222222 18.1 18 1 decreased lactate dehydrogenase level 0.00240324216325977 0.0162226998130494 1.2427041284608 0.722222222222222 18.1 18 1 decreased pulmonary respiratory rate 0.00240324216325977 0.0162226998130494 1.2427041284608 0.722222222222222 18.1 18 1 increased oxygen consumption 2.81793351842491e-11 1.46033533897541e-09 1.24048104415229 0.720930232558139 18.1 18 1 increased circulating creatinine level 2.81793351842491e-11 1.46033533897541e-09 1.24048104415229 0.720930232558139 18.1 18 1 delayed endochondral bone ossification 2.63165756301127e-06 4.90355669512399e-05 1.24048104415229 0.720930232558139 18.1 18 1 abnormal nest building behavior 0.000364947665246982 0.00345831358972141 1.23888042345016 0.72 18.1 18 1 abnormal developmental patterning 9.65819234716769e-11 4.66500067253973e-09 1.23804107356977 0.719512195121951 18.1 18 1 increased hepatocellular carcinoma incidence 7.11849184147439e-08 1.98957847816489e-06 1.23767293765732 0.719298245614035 18.1 18 1 abnormal craniofacial morphology 4.63948457519384e-13 3.11911294075532e-11 1.23620754227766 0.718446601941748 18.1 18 1 pale liver 1.13451764637558e-09 4.37536844241746e-08 1.23236979059419 0.716216216216216 18.1 18 1 embryonic lethality, complete penetrance 1.20579966658286e-36 5.99885334124972e-34 1.229818602171 0.714733542319749 18.1 18 1 polyuria 6.51182337903947e-10 2.61260655731624e-08 1.22904803913706 0.714285714285714 18.1 18 1 spina bifida 5.21106631856112e-06 8.90895358585622e-05 1.22904803913706 0.714285714285714 18.1 18 1 increased carcinoma incidence 3.22689387611212e-05 0.000436244484610266 1.22904803913706 0.714285714285714 18.1 18 1 abnormal embryonic epiblast morphology 3.22689387611212e-05 0.000436244484610266 1.22904803913706 0.714285714285714 18.1 18 1 abnormal scapula morphology 0.00131723413079565 0.00990472244331698 1.22904803913706 0.714285714285714 18.1 18 1 abnormal embryonic/fetal subventricular zone morphology 0.00131723413079565 0.00990472244331698 1.22904803913706 0.714285714285714 18.1 18 1 decreased cochlear outer hair cell number 0.00131723413079565 0.00990472244331698 1.22904803913706 0.714285714285714 18.1 18 1 absent segment of posterior cerebral artery 0.00131723413079565 0.00990472244331698 1.22904803913706 0.714285714285714 18.1 18 1 premature aging 0.000203355094431045 0.00210330892888659 1.22904803913706 0.714285714285714 18.1 18 1 midline facial cleft 0.00896001991886648 0.0463851187267021 1.22904803913706 0.714285714285714 18.1 18 1 irregularly shaped pupil 0.00896001991886648 0.0463851187267021 1.22904803913706 0.714285714285714 18.1 18 1 abnormal pinna reflex 0.00896001991886648 0.0463851187267021 1.22904803913706 0.714285714285714 18.1 18 1 abnormal adrenal gland secretion 0.00896001991886648 0.0463851187267021 1.22904803913706 0.714285714285714 18.1 18 1 abnormal fluid regulation 0.00896001991886648 0.0463851187267021 1.22904803913706 0.714285714285714 18.1 18 1 increased lactate dehydrogenase level 0.00896001991886648 0.0463851187267021 1.22904803913706 0.714285714285714 18.1 18 1 amyloid beta deposits 0.00896001991886648 0.0463851187267021 1.22904803913706 0.714285714285714 18.1 18 1 increased stomach tumor incidence 0.00896001991886648 0.0463851187267021 1.22904803913706 0.714285714285714 18.1 18 1 abnormal renal tubule epithelial cell primary cilium morphology 0.00896001991886648 0.0463851187267021 1.22904803913706 0.714285714285714 18.1 18 1 abnormal vitelline vein topology 0.00896001991886648 0.0463851187267021 1.22904803913706 0.714285714285714 18.1 18 1 cochlear degeneration 0.0681509610367133 0.193522278058019 1.22904803913706 0.714285714285714 18.1 18 1 growth retardation of molars 0.0681509610367133 0.193522278058019 1.22904803913706 0.714285714285714 18.1 18 1 asymmetric rib joints 0.0681509610367133 0.193522278058019 1.22904803913706 0.714285714285714 18.1 18 1 failure of atrioventricular cushion closure 0.0681509610367133 0.193522278058019 1.22904803913706 0.714285714285714 18.1 18 1 cellular necrosis 0.0681509610367133 0.193522278058019 1.22904803913706 0.714285714285714 18.1 18 1 polyphalangy 0.0681509610367133 0.193522278058019 1.22904803913706 0.714285714285714 18.1 18 1 decreased Schwann cell number 0.0681509610367133 0.193522278058019 1.22904803913706 0.714285714285714 18.1 18 1 absent epidermis stratum corneum 0.0681509610367133 0.193522278058019 1.22904803913706 0.714285714285714 18.1 18 1 retina hyperplasia 0.0681509610367133 0.193522278058019 1.22904803913706 0.714285714285714 18.1 18 1 abnormal circulating free fatty acids level 0.0681509610367133 0.193522278058019 1.22904803913706 0.714285714285714 18.1 18 1 abnormal axial mesoderm 0.0681509610367133 0.193522278058019 1.22904803913706 0.714285714285714 18.1 18 1 absent amniotic folds 0.0681509610367133 0.193522278058019 1.22904803913706 0.714285714285714 18.1 18 1 decreased activated T cell number 0.0681509610367133 0.193522278058019 1.22904803913706 0.714285714285714 18.1 18 1 abnormal melanocyte morphology 0.0681509610367133 0.193522278058019 1.22904803913706 0.714285714285714 18.1 18 1 detached tectorial membrane 0.0681509610367133 0.193522278058019 1.22904803913706 0.714285714285714 18.1 18 1 decreased cardiomyocyte apoptosis 0.0681509610367133 0.193522278058019 1.22904803913706 0.714285714285714 18.1 18 1 anuria 0.0681509610367133 0.193522278058019 1.22904803913706 0.714285714285714 18.1 18 1 abnormal hard palate morphology 0.0681509610367133 0.193522278058019 1.22904803913706 0.714285714285714 18.1 18 1 abnormal nephron morphology 0.0681509610367133 0.193522278058019 1.22904803913706 0.714285714285714 18.1 18 1 renal necrosis 0.0681509610367133 0.193522278058019 1.22904803913706 0.714285714285714 18.1 18 1 abnormal optic tract morphology 0.0681509610367133 0.193522278058019 1.22904803913706 0.714285714285714 18.1 18 1 utricular macular degeneration 0.0681509610367133 0.193522278058019 1.22904803913706 0.714285714285714 18.1 18 1 urolithiasis 0.0681509610367133 0.193522278058019 1.22904803913706 0.714285714285714 18.1 18 1 abnormal renal/urinary system physiology 0.0681509610367133 0.193522278058019 1.22904803913706 0.714285714285714 18.1 18 1 retinal pigment epithelium atrophy 0.0681509610367133 0.193522278058019 1.22904803913706 0.714285714285714 18.1 18 1 uremia 0.0681509610367133 0.193522278058019 1.22904803913706 0.714285714285714 18.1 18 1 abnormal uterus physiology 0.0681509610367133 0.193522278058019 1.22904803913706 0.714285714285714 18.1 18 1 heart hemorrhage 0.0681509610367133 0.193522278058019 1.22904803913706 0.714285714285714 18.1 18 1 postaxial polydactyly 0.0681509610367133 0.193522278058019 1.22904803913706 0.714285714285714 18.1 18 1 abnormal sperm annulus morphology 0.0681509610367133 0.193522278058019 1.22904803913706 0.714285714285714 18.1 18 1 decreased DN4 thymocyte number 0.0681509610367133 0.193522278058019 1.22904803913706 0.714285714285714 18.1 18 1 focal dorsal hair loss 0.0681509610367133 0.193522278058019 1.22904803913706 0.714285714285714 18.1 18 1 abnormal retina inner limiting membrane morphology 0.0681509610367133 0.193522278058019 1.22904803913706 0.714285714285714 18.1 18 1 thick mitral valve cusps 0.0681509610367133 0.193522278058019 1.22904803913706 0.714285714285714 18.1 18 1 abnormal outer hair cell kinocilium morphology 0.0681509610367133 0.193522278058019 1.22904803913706 0.714285714285714 18.1 18 1 small tail bud 0.0681509610367133 0.193522278058019 1.22904803913706 0.714285714285714 18.1 18 1 impaired mammary gland growth during pregnancy 0.0681509610367133 0.193522278058019 1.22904803913706 0.714285714285714 18.1 18 1 ductus venosus stenosis 0.0681509610367133 0.193522278058019 1.22904803913706 0.714285714285714 18.1 18 1 decreased cell proliferation 1.03084742563617e-21 2.3311208829727e-19 1.22771933855421 0.713513513513514 18.1 18 1 abnormal eye morphology 1.44493623570201e-16 1.49761620262865e-14 1.22551121024746 0.712230215827338 18.1 18 1 distended pericardium 4.84230814730453e-07 1.0754679925375e-05 1.22432093129423 0.711538461538462 18.1 18 1 kinked neural tube 4.84230814730453e-07 1.0754679925375e-05 1.22432093129423 0.711538461538462 18.1 18 1 impaired branching involved in ureteric bud morphogenesis 1.81635253072007e-05 0.000267347746755395 1.22257936524686 0.710526315789474 18.1 18 1 prenatal lethality 4.5655349753396e-08 1.33609038248909e-06 1.22111869694908 0.709677419354839 18.1 18 1 osteopetrosis 0.000113487900766455 0.0012919961242863 1.22111869694908 0.709677419354839 18.1 18 1 preweaning lethality, complete penetrance 3.2376996213378e-81 1.61075556161555e-77 1.22074366049424 0.709459459459459 18.1 18 1 embryonic lethality during organogenesis, complete penetrance 2.20046403497886e-61 2.18946171480397e-58 1.21983017884353 0.708928571428571 18.1 18 1 abnormal placenta morphology 7.29256124660871e-10 2.87940414300622e-08 1.21971349706766 0.708860759493671 18.1 18 1 abnormal nervous system morphology 7.29256124660871e-10 2.87940414300622e-08 1.21971349706766 0.708860759493671 18.1 18 1 increased hemangiosarcoma incidence 0.000725054813688202 0.00619784827852029 1.21880597214425 0.708333333333333 18.1 18 1 abnormal brain morphology 1.55252212979084e-18 2.45439092534875e-16 1.21836066488369 0.708074534161491 18.1 18 1 abnormal embryo size 1.94947203975555e-13 1.36600329546252e-11 1.21817150781726 0.707964601769911 18.1 18 1 hemopericardium 1.02291834209692e-05 0.000163109575382442 1.21705732656011 0.707317073170732 18.1 18 1 abnormal embryo development 1.06356608943865e-15 9.9834741414288e-14 1.21458865044133 0.705882352941177 18.1 18 1 abnormal gastrulation 9.45791623941738e-07 1.96054722046256e-05 1.21458865044133 0.705882352941177 18.1 18 1 small lung 9.45791623941738e-07 1.96054722046256e-05 1.21458865044133 0.705882352941177 18.1 18 1 abnormal endoderm development 6.34297572531738e-05 0.000779168005764296 1.21458865044133 0.705882352941177 18.1 18 1 abnormal direction of heart looping 6.34297572531738e-05 0.000779168005764296 1.21458865044133 0.705882352941177 18.1 18 1 aminoaciduria 0.00480721654753077 0.0286075386650306 1.21458865044133 0.705882352941177 18.1 18 1 abnormal involuntary movement 0.00480721654753077 0.0286075386650306 1.21458865044133 0.705882352941177 18.1 18 1 abnormal ectoplacental cone morphology 0.00480721654753077 0.0286075386650306 1.21458865044133 0.705882352941177 18.1 18 1 abnormal ductus venosus valve morphology 0.00480721654753077 0.0286075386650306 1.21458865044133 0.705882352941177 18.1 18 1 small kidney 1.36258792822961e-10 6.33539714293676e-09 1.21228829314883 0.704545454545455 18.1 18 1 increased cell proliferation 5.35618019743435e-07 1.16362430053432e-05 1.21083992003873 0.703703703703704 18.1 18 1 abnormal maxilla morphology 5.35618019743435e-07 1.16362430053432e-05 1.21083992003873 0.703703703703704 18.1 18 1 abnormal apoptosis 5.35618019743435e-07 1.16362430053432e-05 1.21083992003873 0.703703703703704 18.1 18 1 abnormal long bone epiphyseal plate proliferative zone 5.35618019743435e-07 1.16362430053432e-05 1.21083992003873 0.703703703703704 18.1 18 1 abnormal neuronal precursor proliferation 5.35618019743435e-07 1.16362430053432e-05 1.21083992003873 0.703703703703704 18.1 18 1 abnormal skin appearance 0.000400543076008053 0.00375981472290578 1.21083992003873 0.703703703703704 18.1 18 1 abnormal vocalization 3.55014842845466e-05 0.00047351175419737 1.2091175303943 0.702702702702703 18.1 18 1 increased respiratory quotient 3.24985214761482e-06 5.9881534942162e-05 1.20812807251345 0.702127659574468 18.1 18 1 decreased brain weight 3.0338978707806e-07 7.18744852720642e-06 1.20748579283641 0.701754385964912 18.1 18 1 increased tumor incidence 4.06719184520716e-14 3.2117903856993e-12 1.20724234812011 0.701612903225806 18.1 18 1 abnormal embryonic tissue morphology 2.21603965596766e-16 2.16172495851747e-14 1.20563760029635 0.700680272108844 18.1 18 1 oxidative stress 1.50035891399426e-10 6.84796843772608e-09 1.20446707835432 0.7 18.1 18 1 absent mesoderm 1.71886632261413e-07 4.25440793781358e-06 1.20446707835432 0.7 18.1 18 1 abnormal interventricular septum morphology 1.83336455719389e-06 3.52161724789174e-05 1.20446707835432 0.7 18.1 18 1 enhanced paired-pulse facilitation 0.000221957773688442 0.00227678334865979 1.20446707835432 0.7 18.1 18 1 abnormal optic cup morphology 0.000221957773688442 0.00227678334865979 1.20446707835432 0.7 18.1 18 1 abnormal basioccipital bone morphology 0.00260302745478504 0.0173129165609032 1.20446707835432 0.7 18.1 18 1 abnormal vascular regression 0.00260302745478504 0.0173129165609032 1.20446707835432 0.7 18.1 18 1 abnormal hair texture 0.00260302745478504 0.0173129165609032 1.20446707835432 0.7 18.1 18 1 abnormal sperm mitochondrial sheath morphology 0.00260302745478504 0.0173129165609032 1.20446707835432 0.7 18.1 18 1 abnormal auchene hair morphology 0.0343061544202627 0.120919890617561 1.20446707835432 0.7 18.1 18 1 absent palatine bone horizontal plate 0.0343061544202627 0.120919890617561 1.20446707835432 0.7 18.1 18 1 increased cranium width 0.0343061544202627 0.120919890617561 1.20446707835432 0.7 18.1 18 1 kidney hemorrhage 0.0343061544202627 0.120919890617561 1.20446707835432 0.7 18.1 18 1 enlarged testis 0.0343061544202627 0.120919890617561 1.20446707835432 0.7 18.1 18 1 abnormal prostate gland epithelium morphology 0.0343061544202627 0.120919890617561 1.20446707835432 0.7 18.1 18 1 fused cornea and lens 0.0343061544202627 0.120919890617561 1.20446707835432 0.7 18.1 18 1 absent trophoblast giant cells 0.0343061544202627 0.120919890617561 1.20446707835432 0.7 18.1 18 1 abnormal pituitary secretion 0.0343061544202627 0.120919890617561 1.20446707835432 0.7 18.1 18 1 abnormal mammary gland physiology 0.0343061544202627 0.120919890617561 1.20446707835432 0.7 18.1 18 1 impaired social transmission of food preference 0.0343061544202627 0.120919890617561 1.20446707835432 0.7 18.1 18 1 acrania 0.0343061544202627 0.120919890617561 1.20446707835432 0.7 18.1 18 1 rickets 0.0343061544202627 0.120919890617561 1.20446707835432 0.7 18.1 18 1 absent seminal vesicle 0.0343061544202627 0.120919890617561 1.20446707835432 0.7 18.1 18 1 absent coat pigmentation 0.0343061544202627 0.120919890617561 1.20446707835432 0.7 18.1 18 1 abnormal gonadal fat pad morphology 0.0343061544202627 0.120919890617561 1.20446707835432 0.7 18.1 18 1 vascular smooth muscle hyperplasia 0.0343061544202627 0.120919890617561 1.20446707835432 0.7 18.1 18 1 crystalluria 0.0343061544202627 0.120919890617561 1.20446707835432 0.7 18.1 18 1 protruding tongue 0.0343061544202627 0.120919890617561 1.20446707835432 0.7 18.1 18 1 abnormal cerebellar granule cell migration 0.0343061544202627 0.120919890617561 1.20446707835432 0.7 18.1 18 1 abnormal retinal blood vessel pattern 0.0343061544202627 0.120919890617561 1.20446707835432 0.7 18.1 18 1 aorta stenosis 0.0343061544202627 0.120919890617561 1.20446707835432 0.7 18.1 18 1 abnormal inferior vena cava valve morphology 0.0343061544202627 0.120919890617561 1.20446707835432 0.7 18.1 18 1 thin ventricle myocardium compact layer 0.0343061544202627 0.120919890617561 1.20446707835432 0.7 18.1 18 1 decreased macrophage cytokine production 0.0343061544202627 0.120919890617561 1.20446707835432 0.7 18.1 18 1 increased fatty acid oxidation 0.0343061544202627 0.120919890617561 1.20446707835432 0.7 18.1 18 1 abnormal fertility/fecundity 9.26492867963888e-09 3.09349128732909e-07 1.2021099999231 0.698630136986301 18.1 18 1 abnormal organ of Corti morphology 1.11635480621377e-05 0.000176874686653296 1.20046552659899 0.697674418604651 18.1 18 1 increased circulating alkaline phosphatase level 1.36054100159997e-17 1.78123460077891e-15 1.20021851723138 0.697530864197531 18.1 18 1 myeloid hyperplasia 0.000123323706948082 0.00139123683008323 1.19925293515798 0.696969696969697 18.1 18 1 abnormal cranial nerve morphology 0.00141943150219256 0.0105398085424 1.19698591637696 0.695652173913043 18.1 18 1 abnormal chondrocyte physiology 0.00141943150219256 0.0105398085424 1.19698591637696 0.695652173913043 18.1 18 1 short snout 5.15218945035576e-12 3.12587103847804e-10 1.1949078158277 0.694444444444444 18.1 18 1 abnormal pharyngeal arch morphology 6.86789122700258e-05 0.000837445069959261 1.1949078158277 0.694444444444444 18.1 18 1 narrow eye opening 6.86789122700258e-05 0.000837445069959261 1.1949078158277 0.694444444444444 18.1 18 1 preweaning lethality, incomplete penetrance 1.90297378119923e-41 1.18341182018327e-38 1.19479095442762 0.694376528117359 18.1 18 1 abnormal stomach morphology 0.000778312938963583 0.00660490735591128 1.19123117639438 0.692307692307692 18.1 18 1 abnormal Schwann cell morphology 0.000778312938963583 0.00660490735591128 1.19123117639438 0.692307692307692 18.1 18 1 thick skin 0.000778312938963583 0.00660490735591128 1.19123117639438 0.692307692307692 18.1 18 1 abnormal membranous labyrinth morphology 0.0178120531191637 0.0757076906623105 1.19123117639438 0.692307692307692 18.1 18 1 absent trabeculae carneae 0.0178120531191637 0.0757076906623105 1.19123117639438 0.692307692307692 18.1 18 1 excessive scratching 0.0178120531191637 0.0757076906623105 1.19123117639438 0.692307692307692 18.1 18 1 abnormal grip strength 0.0178120531191637 0.0757076906623105 1.19123117639438 0.692307692307692 18.1 18 1 abnormal tail bud morphology 0.0178120531191637 0.0757076906623105 1.19123117639438 0.692307692307692 18.1 18 1 abnormal bile duct development 0.0178120531191637 0.0757076906623105 1.19123117639438 0.692307692307692 18.1 18 1 axonal dystrophy 0.0178120531191637 0.0757076906623105 1.19123117639438 0.692307692307692 18.1 18 1 vestibular hair cell degeneration 0.0178120531191637 0.0757076906623105 1.19123117639438 0.692307692307692 18.1 18 1 increased circulating thyroid-stimulating hormone level 0.0178120531191637 0.0757076906623105 1.19123117639438 0.692307692307692 18.1 18 1 orthokeratosis 0.0178120531191637 0.0757076906623105 1.19123117639438 0.692307692307692 18.1 18 1 increased grip strength 3.12451116181746e-10 1.37561442743733e-08 1.19123117639438 0.692307692307692 18.1 18 1 increased hepatocyte apoptosis 3.83242025168013e-05 0.000509793870377236 1.19123117639438 0.692307692307692 18.1 18 1 double outlet right ventricle 9.80389140398569e-12 5.35981975108009e-10 1.18999417621121 0.691588785046729 18.1 18 1 pallor 3.00737795364014e-18 4.40050156451755e-16 1.18971850188467 0.691428571428571 18.1 18 1 pericardial edema 5.9736943787754e-08 1.69823597339472e-06 1.1892847202238 0.691176470588235 18.1 18 1 decreased circulating calcium level 1.11767925181522e-06 2.26957317460437e-05 1.1888246487653 0.690909090909091 18.1 18 1 decreased circulating total protein level 1.11767925181522e-06 2.26957317460437e-05 1.1888246487653 0.690909090909091 18.1 18 1 abnormal heart development 1.78643876149625e-16 1.81378221192732e-14 1.18704259982478 0.689873417721519 18.1 18 1 increased mortality induced by gamma-irradiation 0.000428683977477701 0.00397441544689978 1.18666707227026 0.689655172413793 18.1 18 1 abnormal ectoderm development 1.19945116039668e-05 0.000186922658658399 1.18534855330108 0.688888888888889 18.1 18 1 small placenta 1.19945116039668e-05 0.000186922658658399 1.18534855330108 0.688888888888889 18.1 18 1 extramedullary hematopoiesis 1.85802292394319e-11 9.9394237060402e-10 1.18498782641328 0.688679245283019 18.1 18 1 hypoglycemia 3.3671444260287e-10 1.46943364206077e-08 1.18411510007183 0.688172043010753 18.1 18 1 vertebral transformation 6.7247677147778e-06 0.000113409218240744 1.18295873766942 0.6875 18.1 18 1 abnormal auditory brainstem response waveform shape 0.000236986034074571 0.00242095589224023 1.18295873766942 0.6875 18.1 18 1 failure of tooth eruption 0.00942574049797946 0.0474558010391489 1.18295873766942 0.6875 18.1 18 1 abnormal bone marrow cell number 0.00942574049797946 0.0474558010391489 1.18295873766942 0.6875 18.1 18 1 increased pancreatic beta cell number 0.00942574049797946 0.0474558010391489 1.18295873766942 0.6875 18.1 18 1 blepharitis 0.00942574049797946 0.0474558010391489 1.18295873766942 0.6875 18.1 18 1 kidney degeneration 0.00942574049797946 0.0474558010391489 1.18295873766942 0.6875 18.1 18 1 decreased skeletal muscle weight 0.00942574049797946 0.0474558010391489 1.18295873766942 0.6875 18.1 18 1 abnormal pulmonary alveolus wall morphology 0.00942574049797946 0.0474558010391489 1.18295873766942 0.6875 18.1 18 1 decreased midbrain size 0.00942574049797946 0.0474558010391489 1.18295873766942 0.6875 18.1 18 1 embryonic lethality during organogenesis, incomplete penetrance 6.48740231199911e-23 1.53689650010455e-20 1.18202359242225 0.68695652173913 18.1 18 1 microphthalmia 1.11746802276301e-15 1.0295191506011e-13 1.18085007681796 0.686274509803922 18.1 18 1 distended abdomen 3.7749303486829e-06 6.87922288816756e-05 1.18085007681796 0.686274509803922 18.1 18 1 abnormal artery morphology 0.000131416997599471 0.00144966643693429 1.17988611757158 0.685714285714286 18.1 18 1 abnormal hippocampus pyramidal cell morphology 0.000131416997599471 0.00144966643693429 1.17988611757158 0.685714285714286 18.1 18 1 decreased bone mineralization 0.000131416997599471 0.00144966643693429 1.17988611757158 0.685714285714286 18.1 18 1 abnormal neural tube morphology 2.06589209302604e-16 2.05556263256091e-14 1.17897571161666 0.685185185185185 18.1 18 1 neurodegeneration 2.1213977760394e-06 4.04366051179924e-05 1.17897571161666 0.685185185185185 18.1 18 1 decreased bone marrow cell number 3.61984386547139e-08 1.0914377715588e-06 1.17853921561088 0.684931506849315 18.1 18 1 seminiferous tubule degeneration 3.61984386547139e-08 1.0914377715588e-06 1.17853921561088 0.684931506849315 18.1 18 1 incomplete somite formation 7.30670620687958e-05 0.0008844492306381 1.1772986480155 0.684210526315789 18.1 18 1 decreased tumor incidence 0.00505288903150114 0.0290278555793513 1.1772986480155 0.684210526315789 18.1 18 1 abnormal digestive system development 0.00505288903150114 0.0290278555793513 1.1772986480155 0.684210526315789 18.1 18 1 oliguria 0.00505288903150114 0.0290278555793513 1.1772986480155 0.684210526315789 18.1 18 1 abnormal sternebra morphology 0.00505288903150114 0.0290278555793513 1.1772986480155 0.684210526315789 18.1 18 1 abnormal blastocyst morphology 0.00505288903150114 0.0290278555793513 1.1772986480155 0.684210526315789 18.1 18 1 decreased eye pigmentation 0.00505288903150114 0.0290278555793513 1.1772986480155 0.684210526315789 18.1 18 1 decreased liver regeneration 0.00505288903150114 0.0290278555793513 1.1772986480155 0.684210526315789 18.1 18 1 abnormal facial morphology 1.19335277526152e-06 2.40361540766238e-05 1.1772986480155 0.684210526315789 18.1 18 1 abnormal circulating amino acid level 1.19335277526152e-06 2.40361540766238e-05 1.1772986480155 0.684210526315789 18.1 18 1 intracranial hemorrhage 6.71904317216938e-07 1.43464548418638e-05 1.17578929077445 0.683333333333333 18.1 18 1 increased erythrocyte cell number 6.71904317216938e-07 1.43464548418638e-05 1.17578929077445 0.683333333333333 18.1 18 1 palatal shelves fail to meet at midline 4.0716696740118e-05 0.000540174843418898 1.1750898325408 0.682926829268293 18.1 18 1 intestinal inflammation 0.00273432605631444 0.0179699763938762 1.17318221917628 0.681818181818182 18.1 18 1 intracerebral hemorrhage 0.00273432605631444 0.0179699763938762 1.17318221917628 0.681818181818182 18.1 18 1 abnormal locomotor activation 1.19261738202271e-09 4.52921486684197e-08 1.17232274502304 0.681318681318681 18.1 18 1 pulmonary hypoplasia 1.27151343433841e-05 0.000195240102957827 1.17151813092213 0.680851063829787 18.1 18 1 neuron degeneration 1.27151343433841e-05 0.000195240102957827 1.17151813092213 0.680851063829787 18.1 18 1 abnormal liver physiology 2.17411373662048e-10 9.657335571149e-09 1.17005373325848 0.68 18.1 18 1 delayed bone ossification 3.84361078630851e-08 1.13821212273124e-06 1.17005373325848 0.68 18.1 18 1 spontaneous skin ulceration 0.00149028250412579 0.010951485166951 1.17005373325848 0.68 18.1 18 1 abnormal cochlear outer hair cell morphology 0.00149028250412579 0.010951485166951 1.17005373325848 0.68 18.1 18 1 abnormal preimplantation embryo development 0.00149028250412579 0.010951485166951 1.17005373325848 0.68 18.1 18 1 cleft palate 4.06403639850767e-13 2.76966864144872e-11 1.16900294409525 0.679389312977099 18.1 18 1 atrioventricular septal defect 3.99492136972006e-06 7.19197818429909e-05 1.16875511646241 0.679245283018868 18.1 18 1 increased exploration in new environment 1.22873195013428e-08 4.04830559729671e-07 1.1683543088093 0.679012345679012 18.1 18 1 perinatal lethality, incomplete penetrance 2.98078601720035e-21 6.17892101482155e-19 1.16487650435026 0.676991150442478 18.1 18 1 embryonic growth arrest 1.6956288744688e-21 3.66771897847055e-19 1.16464377507748 0.676855895196507 18.1 18 1 decreased circulating serum albumin level 4.05312691091903e-10 1.73830227429501e-08 1.16449198051572 0.676767676767677 18.1 18 1 abnormal nervous system development 0.000248556510855615 0.00252360947246263 1.16398079000627 0.676470588235294 18.1 18 1 increased erythroid progenitor cell number 0.00013779855390644 0.00151001719313775 1.16261300999452 0.675675675675676 18.1 18 1 abnormal chromosome morphology 0.00013779855390644 0.00151001719313775 1.16261300999452 0.675675675675676 18.1 18 1 abnormal double-strand DNA break repair 4.26760875802135e-05 0.000556944264549768 1.16045000904569 0.674418604651163 18.1 18 1 embryonic lethality between implantation and placentation, complete penetrance 2.38237493442109e-05 0.000340583772952441 1.15958010649018 0.673913043478261 18.1 18 1 decreased hemoglobin content 1.46220252302197e-13 1.05426921043975e-11 1.15931481705836 0.673758865248227 18.1 18 1 absent kidney 1.33225528511554e-05 0.00020145805603191 1.15881672261494 0.673469387755102 18.1 18 1 decreased urine osmolality 1.33225528511554e-05 0.00020145805603191 1.15881672261494 0.673469387755102 18.1 18 1 abnormal craniofacial development 1.33225528511554e-05 0.00020145805603191 1.15881672261494 0.673469387755102 18.1 18 1 eyelids open at birth 7.46151515106828e-06 0.000124150628349715 1.15814142149454 0.673076923076923 18.1 18 1 increased circulating calcium level 4.18459696472242e-06 7.43513210696216e-05 1.15753978958727 0.672727272727273 18.1 18 1 decreased percent body fat/body weight 1.33024623871066e-07 3.46490839664165e-06 1.15496843129866 0.671232876712329 18.1 18 1 abnormal somite development 4.23963330618107e-08 1.24805773362431e-06 1.1543717025819 0.670886075949367 18.1 18 1 increased monocyte cell number 7.86809305267661e-10 3.0821860580367e-08 1.15284706071056 0.67 18.1 18 1 abnormal coat/hair pigmentation 8.12370987122719e-11 3.96229966758385e-09 1.15223253669099 0.669642857142857 18.1 18 1 ventricular septal defect 8.74887374059058e-13 5.72705879729449e-11 1.15132882489751 0.669117647058823 18.1 18 1 abnormal behavior 1.40353312037371e-24 3.87920959658846e-22 1.15123780356579 0.669064748201439 18.1 18 1 prenatal lethality, complete penetrance 1.40353312037371e-24 3.87920959658846e-22 1.15123780356579 0.669064748201439 18.1 18 1 perinatal lethality, complete penetrance 6.70180962617733e-19 1.1497069962149e-16 1.14711150319459 0.666666666666667 18.1 18 1 hydronephrosis 2.49176950802902e-08 7.79657440405306e-07 1.14711150319459 0.666666666666667 18.1 18 1 decreased spleen weight 4.34900133191334e-07 9.98688331760502e-06 1.14711150319459 0.666666666666667 18.1 18 1 gliosis 1.37182798218073e-06 2.67640949464672e-05 1.14711150319459 0.666666666666667 18.1 18 1 oligodactyly 2.46958676005965e-05 0.000349123922994686 1.14711150319459 0.666666666666667 18.1 18 1 irregular heartbeat 4.42127562700761e-05 0.00056984057627883 1.14711150319459 0.666666666666667 18.1 18 1 disheveled coat 7.93032009215185e-05 0.000948397655251333 1.14711150319459 0.666666666666667 18.1 18 1 abnormal digestive system morphology 0.00280818487920128 0.0181527563414596 1.14711150319459 0.666666666666667 18.1 18 1 hemolytic anemia 0.00280818487920128 0.0181527563414596 1.14711150319459 0.666666666666667 18.1 18 1 abnormal impulse conducting system conduction 0.00280818487920128 0.0181527563414596 1.14711150319459 0.666666666666667 18.1 18 1 abnormal tumor morphology 0.00280818487920128 0.0181527563414596 1.14711150319459 0.666666666666667 18.1 18 1 abnormal inner cell mass apoptosis 0.00280818487920128 0.0181527563414596 1.14711150319459 0.666666666666667 18.1 18 1 abnormal truncus arteriosus septation 0.00280818487920128 0.0181527563414596 1.14711150319459 0.666666666666667 18.1 18 1 abnormal lung saccule morphology 0.00280818487920128 0.0181527563414596 1.14711150319459 0.666666666666667 18.1 18 1 abnormal hematopoietic system physiology 0.00517461410276385 0.0293963328327643 1.14711150319459 0.666666666666667 18.1 18 1 left pulmonary isomerism 0.00517461410276385 0.0293963328327643 1.14711150319459 0.666666666666667 18.1 18 1 abnormal tumor vascularization 0.00517461410276385 0.0293963328327643 1.14711150319459 0.666666666666667 18.1 18 1 vascular ring 0.00517461410276385 0.0293963328327643 1.14711150319459 0.666666666666667 18.1 18 1 embryonic lethality at implantation, complete penetrance 0.00517461410276385 0.0293963328327643 1.14711150319459 0.666666666666667 18.1 18 1 abnormal adipose tissue distribution 0.0344895125198631 0.120919890617561 1.14711150319459 0.666666666666667 18.1 18 1 impaired embryo implantation 0.0344895125198631 0.120919890617561 1.14711150319459 0.666666666666667 18.1 18 1 altered tumor susceptibility 0.0344895125198631 0.120919890617561 1.14711150319459 0.666666666666667 18.1 18 1 increased urine phosphate level 0.0344895125198631 0.120919890617561 1.14711150319459 0.666666666666667 18.1 18 1 small intestinal inflammation 0.0344895125198631 0.120919890617561 1.14711150319459 0.666666666666667 18.1 18 1 increased osteosarcoma incidence 0.0344895125198631 0.120919890617561 1.14711150319459 0.666666666666667 18.1 18 1 abnormal nucleotide metabolism 0.0344895125198631 0.120919890617561 1.14711150319459 0.666666666666667 18.1 18 1 abnormal defecation 0.0344895125198631 0.120919890617561 1.14711150319459 0.666666666666667 18.1 18 1 increased hepatocyte proliferation 0.0344895125198631 0.120919890617561 1.14711150319459 0.666666666666667 18.1 18 1 pale placenta 0.0344895125198631 0.120919890617561 1.14711150319459 0.666666666666667 18.1 18 1 vestibular saccular macula degeneration 0.0344895125198631 0.120919890617561 1.14711150319459 0.666666666666667 18.1 18 1 hydrometra 0.0344895125198631 0.120919890617561 1.14711150319459 0.666666666666667 18.1 18 1 increased fibrosarcoma incidence 0.0344895125198631 0.120919890617561 1.14711150319459 0.666666666666667 18.1 18 1 increased skeletal muscle glycogen level 0.0344895125198631 0.120919890617561 1.14711150319459 0.666666666666667 18.1 18 1 persistent right dorsal aorta 0.0344895125198631 0.120919890617561 1.14711150319459 0.666666666666667 18.1 18 1 abnormal colon goblet cell morphology 0.0344895125198631 0.120919890617561 1.14711150319459 0.666666666666667 18.1 18 1 small liver 7.80675291918351e-08 2.15769976516322e-06 1.14711150319459 0.666666666666667 18.1 18 1 diluted coat color 7.74196855708135e-06 0.00012669833411671 1.14711150319459 0.666666666666667 18.1 18 1 impaired limb coordination 7.74196855708135e-06 0.00012669833411671 1.14711150319459 0.666666666666667 18.1 18 1 abnormal cell adhesion 7.74196855708135e-06 0.00012669833411671 1.14711150319459 0.666666666666667 18.1 18 1 axon degeneration 7.74196855708135e-06 0.00012669833411671 1.14711150319459 0.666666666666667 18.1 18 1 abnormal iris morphology 0.000142552781172784 0.001555263347225 1.14711150319459 0.666666666666667 18.1 18 1 abnormal limb bone morphology 0.000256893168258361 0.00259238034905749 1.14711150319459 0.666666666666667 18.1 18 1 renal hypoplasia 0.000256893168258361 0.00259238034905749 1.14711150319459 0.666666666666667 18.1 18 1 decreased brown adipose tissue amount 0.00046431068832755 0.0042329904829758 1.14711150319459 0.666666666666667 18.1 18 1 abnormal locomotor coordination 0.00046431068832755 0.0042329904829758 1.14711150319459 0.666666666666667 18.1 18 1 single kidney 0.00046431068832755 0.0042329904829758 1.14711150319459 0.666666666666667 18.1 18 1 abnormal heart valve morphology 0.00153385266487464 0.0110593000112338 1.14711150319459 0.666666666666667 18.1 18 1 rectal prolapse 0.00153385266487464 0.0110593000112338 1.14711150319459 0.666666666666667 18.1 18 1 abnormal trigeminal ganglion morphology 0.00153385266487464 0.0110593000112338 1.14711150319459 0.666666666666667 18.1 18 1 increased brain weight 0.00153385266487464 0.0110593000112338 1.14711150319459 0.666666666666667 18.1 18 1 abnormal fetal cardiomyocyte proliferation 0.00153385266487464 0.0110593000112338 1.14711150319459 0.666666666666667 18.1 18 1 abnormal eye muscle morphology 0.00153385266487464 0.0110593000112338 1.14711150319459 0.666666666666667 18.1 18 1 decreased circulating fructosamine level 0.00153385266487464 0.0110593000112338 1.14711150319459 0.666666666666667 18.1 18 1 abnormal bone trabecula morphology 0.00153385266487464 0.0110593000112338 1.14711150319459 0.666666666666667 18.1 18 1 lowered ear position 0.00961516531607279 0.0474558010391489 1.14711150319459 0.666666666666667 18.1 18 1 abnormal heart shape 0.00961516531607279 0.0474558010391489 1.14711150319459 0.666666666666667 18.1 18 1 abnormal radius morphology 0.00961516531607279 0.0474558010391489 1.14711150319459 0.666666666666667 18.1 18 1 absent spleen 0.00961516531607279 0.0474558010391489 1.14711150319459 0.666666666666667 18.1 18 1 abnormal redox activity 0.00961516531607279 0.0474558010391489 1.14711150319459 0.666666666666667 18.1 18 1 increased circulating renin level 0.00961516531607279 0.0474558010391489 1.14711150319459 0.666666666666667 18.1 18 1 decreased activity of thyroid 0.00961516531607279 0.0474558010391489 1.14711150319459 0.666666666666667 18.1 18 1 absent ureter 0.00961516531607279 0.0474558010391489 1.14711150319459 0.666666666666667 18.1 18 1 abnormal neutrophil morphology 0.00961516531607279 0.0474558010391489 1.14711150319459 0.666666666666667 18.1 18 1 jerky movement 0.00961516531607279 0.0474558010391489 1.14711150319459 0.666666666666667 18.1 18 1 abnormal pregnancy 0.00961516531607279 0.0474558010391489 1.14711150319459 0.666666666666667 18.1 18 1 small thoracic cage 0.00961516531607279 0.0474558010391489 1.14711150319459 0.666666666666667 18.1 18 1 decreased tumor latency 0.00961516531607279 0.0474558010391489 1.14711150319459 0.666666666666667 18.1 18 1 atrioventricular block 0.00961516531607279 0.0474558010391489 1.14711150319459 0.666666666666667 18.1 18 1 decreased hepatocyte number 0.0180673550498593 0.0757076906623105 1.14711150319459 0.666666666666667 18.1 18 1 abnormal pup retrieval 0.0180673550498593 0.0757076906623105 1.14711150319459 0.666666666666667 18.1 18 1 absent egg cylinders 0.0180673550498593 0.0757076906623105 1.14711150319459 0.666666666666667 18.1 18 1 placental labyrinth hypoplasia 0.0180673550498593 0.0757076906623105 1.14711150319459 0.666666666666667 18.1 18 1 dilated ureter 0.0180673550498593 0.0757076906623105 1.14711150319459 0.666666666666667 18.1 18 1 decreased thymocyte apoptosis 0.0180673550498593 0.0757076906623105 1.14711150319459 0.666666666666667 18.1 18 1 liver vascular congestion 0.0180673550498593 0.0757076906623105 1.14711150319459 0.666666666666667 18.1 18 1 bicuspid aortic valve 0.0180673550498593 0.0757076906623105 1.14711150319459 0.666666666666667 18.1 18 1 abnormal urinary bladder urothelium morphology 0.0674379309688324 0.193522278058019 1.14711150319459 0.666666666666667 18.1 18 1 abnormal sympathetic neuron morphology 0.0674379309688324 0.193522278058019 1.14711150319459 0.666666666666667 18.1 18 1 wavy vibrissae 0.0674379309688324 0.193522278058019 1.14711150319459 0.666666666666667 18.1 18 1 multifocal hepatic necrosis 0.0674379309688324 0.193522278058019 1.14711150319459 0.666666666666667 18.1 18 1 abnormal ion homeostasis 0.0674379309688324 0.193522278058019 1.14711150319459 0.666666666666667 18.1 18 1 increased pheochromocytoma incidence 0.0674379309688324 0.193522278058019 1.14711150319459 0.666666666666667 18.1 18 1 abnormal vomeronasal organ morphology 0.0674379309688324 0.193522278058019 1.14711150319459 0.666666666666667 18.1 18 1 abnormal abdominal wall morphology 0.0674379309688324 0.193522278058019 1.14711150319459 0.666666666666667 18.1 18 1 biliary cyst 0.0674379309688324 0.193522278058019 1.14711150319459 0.666666666666667 18.1 18 1 premature neuronal precursor differentiation 0.0674379309688324 0.193522278058019 1.14711150319459 0.666666666666667 18.1 18 1 abnormal stria vascularis vasculature morphology 0.0674379309688324 0.193522278058019 1.14711150319459 0.666666666666667 18.1 18 1 abnormal intervertebral disk development 0.0674379309688324 0.193522278058019 1.14711150319459 0.666666666666667 18.1 18 1 abnormal optic chiasm morphology 0.0674379309688324 0.193522278058019 1.14711150319459 0.666666666666667 18.1 18 1 multiflagellated sperm 0.0674379309688324 0.193522278058019 1.14711150319459 0.666666666666667 18.1 18 1 axonal spheroids 0.0674379309688324 0.193522278058019 1.14711150319459 0.666666666666667 18.1 18 1 retropulsion 0.0674379309688324 0.193522278058019 1.14711150319459 0.666666666666667 18.1 18 1 decreased effector memory CD4-positive, alpha-beta T cell number 0.0674379309688324 0.193522278058019 1.14711150319459 0.666666666666667 18.1 18 1 decreased airway resistance 0.0674379309688324 0.193522278058019 1.14711150319459 0.666666666666667 18.1 18 1 abnormal oxidative phosphorylation 0.0674379309688324 0.193522278058019 1.14711150319459 0.666666666666667 18.1 18 1 increased core body temperature 0.0674379309688324 0.193522278058019 1.14711150319459 0.666666666666667 18.1 18 1 decreased bone trabecular spacing 0.0674379309688324 0.193522278058019 1.14711150319459 0.666666666666667 18.1 18 1 abnormal coronary sinus connection 0.0674379309688324 0.193522278058019 1.14711150319459 0.666666666666667 18.1 18 1 decreased fatty acid oxidation 0.0674379309688324 0.193522278058019 1.14711150319459 0.666666666666667 18.1 18 1 increased endoplasmic reticulum stress 0.0674379309688324 0.193522278058019 1.14711150319459 0.666666666666667 18.1 18 1 decreased circulating HDL cholesterol level 9.096123571657e-12 5.02813497433262e-10 1.14263059888524 0.6640625 18.1 18 1 abnormal bone structure 6.61003439713074e-17 7.71797532731587e-15 1.14116792027648 0.663212435233161 18.1 18 1 abnormal muscle physiology 1.45765221243559e-08 4.67859339152712e-07 1.14066705654743 0.662921348314607 18.1 18 1 decreased liver weight 4.48891680669253e-07 1.02442023455483e-05 1.13903325317209 0.661971830985915 18.1 18 1 abnormal coat/ hair morphology 1.42021141703566e-05 0.000212817825293747 1.13628969656068 0.660377358490566 18.1 18 1 abnormal myelopoiesis 8.12309323494636e-05 0.000964496153791364 1.13407614520374 0.659090909090909 18.1 18 1 anemia 7.60077969001528e-18 1.05038552660628e-15 1.13352013467333 0.658767772511848 18.1 18 1 decreased total body fat amount 2.25360821206982e-27 8.62438527311336e-25 1.13337364088088 0.658682634730539 18.1 18 1 abnormal visceral yolk sac morphology 1.46767610627439e-07 3.78325835684718e-06 1.13259110441997 0.658227848101266 18.1 18 1 decreased B cell proliferation 1.46767610627439e-07 3.78325835684718e-06 1.13259110441997 0.658227848101266 18.1 18 1 prenatal lethality, incomplete penetrance 6.43009881149875e-25 2.13264943914709e-22 1.13201793078413 0.657894736842105 18.1 18 1 abnormal frontal bone morphology 0.000262282192055757 0.00261546834313956 1.13201793078413 0.657894736842105 18.1 18 1 abnormal reproductive system physiology 0.000262282192055757 0.00261546834313956 1.13201793078413 0.657894736842105 18.1 18 1 spleen hypoplasia 1.58523792225989e-09 5.92974335582178e-08 1.1307241960061 0.657142857142857 18.1 18 1 increased red blood cell distribution width 0.000473073911263225 0.0042329904829758 1.1307241960061 0.657142857142857 18.1 18 1 decreased bone volume 0.000473073911263225 0.0042329904829758 1.1307241960061 0.657142857142857 18.1 18 1 abnormal tooth morphology 2.57207629380276e-06 4.81055622619126e-05 1.12918788595717 0.65625 18.1 18 1 neonatal lethality 0.00085591977298379 0.00692390385462497 1.12918788595717 0.65625 18.1 18 1 abnormal heart atrium morphology 0.00085591977298379 0.00692390385462497 1.12918788595717 0.65625 18.1 18 1 abnormal embryonic hematopoiesis 0.00085591977298379 0.00692390385462497 1.12918788595717 0.65625 18.1 18 1 increased fatty acid level 0.00085591977298379 0.00692390385462497 1.12918788595717 0.65625 18.1 18 1 increased fibroblast apoptosis 0.00085591977298379 0.00692390385462497 1.12918788595717 0.65625 18.1 18 1 abnormal definitive hematopoiesis 1.5373484332131e-08 4.87153404792049e-07 1.12860970475597 0.655913978494624 18.1 18 1 thin ventricular wall 2.71520892817071e-08 8.34737963558044e-07 1.12799297814135 0.655555555555556 18.1 18 1 abnormal spinal nerve morphology 0.00155430400598163 0.0110715184752563 1.12733371865675 0.655172413793103 18.1 18 1 blood in lymph vessels 0.00155430400598163 0.0110715184752563 1.12733371865675 0.655172413793103 18.1 18 1 abnormal snout morphology 2.58223973369415e-05 0.000360860749301359 1.12505166659469 0.653846153846154 18.1 18 1 decreased kidney weight 2.58223973369415e-05 0.000360860749301359 1.12505166659469 0.653846153846154 18.1 18 1 abnormal nasal bone morphology 0.00283511390498777 0.0181527563414596 1.12505166659469 0.653846153846154 18.1 18 1 abnormal ureter morphology 0.00283511390498777 0.0181527563414596 1.12505166659469 0.653846153846154 18.1 18 1 decreased circulating glycerol level 0.00283511390498777 0.0181527563414596 1.12505166659469 0.653846153846154 18.1 18 1 spleen hyperplasia 4.69665453628871e-07 1.06208437809256e-05 1.1241692731307 0.653333333333333 18.1 18 1 abnormal digit morphology 8.31902739460466e-07 1.75369327492196e-05 1.12321334687804 0.652777777777778 18.1 18 1 hydrops fetalis 8.31902739460466e-07 1.75369327492196e-05 1.12321334687804 0.652777777777778 18.1 18 1 abnormal testis morphology 5.32402867100488e-10 2.18901178828507e-08 1.1221742966034 0.652173913043478 18.1 18 1 abnormal coat appearance 1.47446685902757e-06 2.86541899361804e-05 1.1221742966034 0.652173913043478 18.1 18 1 abnormal forelimb morphology 8.24421442560725e-05 0.000971635931931235 1.1221742966034 0.652173913043478 18.1 18 1 abnormal myelin sheath morphology 8.24421442560725e-05 0.000971635931931235 1.1221742966034 0.652173913043478 18.1 18 1 abnormal postnatal growth 0.00519975334529297 0.0293963328327643 1.1221742966034 0.652173913043478 18.1 18 1 conjunctivitis 0.00519975334529297 0.0293963328327643 1.1221742966034 0.652173913043478 18.1 18 1 abnormal sacral vertebrae morphology 0.00519975334529297 0.0293963328327643 1.1221742966034 0.652173913043478 18.1 18 1 abnormal lens development 0.00519975334529297 0.0293963328327643 1.1221742966034 0.652173913043478 18.1 18 1 abnormal palatal shelf fusion at midline 0.00519975334529297 0.0293963328327643 1.1221742966034 0.652173913043478 18.1 18 1 increased bone mineral content 1.6514578919583e-09 6.13134553171086e-08 1.12080160633233 0.651376146788991 18.1 18 1 edema 3.83585434677721e-14 3.07796377019623e-12 1.12043449149239 0.651162790697674 18.1 18 1 abnormal vasculogenesis 0.000147673812491954 0.00158335607143852 1.12043449149239 0.651162790697674 18.1 18 1 increased insulin sensitivity 6.01140072719238e-12 3.54474041096646e-10 1.11903534752199 0.65034965034965 18.1 18 1 abnormal retinal pigment epithelium morphology 2.69487069352263e-07 6.4989872177949e-06 1.11843371561472 0.65 18.1 18 1 abnormal skin pigmentation 0.000265039761868163 0.00261546834313956 1.11843371561472 0.65 18.1 18 1 increased urine glucose level 0.00960263195968817 0.0474558010391489 1.11843371561472 0.65 18.1 18 1 spleen atrophy 0.00960263195968817 0.0474558010391489 1.11843371561472 0.65 18.1 18 1 abnormal postnatal subventricular zone morphology 0.00960263195968817 0.0474558010391489 1.11843371561472 0.65 18.1 18 1 abnormal induced retinal neovascularization 0.00960263195968817 0.0474558010391489 1.11843371561472 0.65 18.1 18 1 abnormal heart electrocardiography waveform feature 0.00960263195968817 0.0474558010391489 1.11843371561472 0.65 18.1 18 1 absent vitelline blood vessels 1.46639897325372e-05 0.000218223617906983 1.11692435837368 0.649122807017544 18.1 18 1 abnormal craniofacial bone morphology 1.46639897325372e-05 0.000218223617906983 1.11692435837368 0.649122807017544 18.1 18 1 abnormal hair follicle development 0.000476760148600367 0.00423550310586933 1.11610848959474 0.648648648648649 18.1 18 1 increased trabecular bone volume 0.000476760148600367 0.00423550310586933 1.11610848959474 0.648648648648649 18.1 18 1 abnormal respiratory electron transport chain 0.000476760148600367 0.00423550310586933 1.11610848959474 0.648648648648649 18.1 18 1 small spleen 4.95479277597542e-08 1.43314500351615e-06 1.11559745090902 0.648351648351648 18.1 18 1 thrombocytopenia 6.10281161426061e-12 3.54474041096646e-10 1.11546704793405 0.648275862068965 18.1 18 1 abnormal chondrocyte morphology 2.61023824053371e-05 0.000361725215784267 1.11524729477252 0.648148148148148 18.1 18 1 corneal opacity 1.49260683588609e-06 2.88490244227767e-05 1.1147985031046 0.647887323943662 18.1 18 1 abnormal trophoblast layer morphology 4.65167769733431e-05 0.000593139454287554 1.11337292957122 0.647058823529412 18.1 18 1 abnormal oocyte morphology 0.000859860013692761 0.00693323106664747 1.11337292957122 0.647058823529412 18.1 18 1 abnormal spleen red pulp morphology 0.000859860013692761 0.00693323106664747 1.11337292957122 0.647058823529412 18.1 18 1 abnormal interatrial septum morphology 0.0178930344071354 0.0757076906623105 1.11337292957122 0.647058823529412 18.1 18 1 hydroureter 0.0178930344071354 0.0757076906623105 1.11337292957122 0.647058823529412 18.1 18 1 abnormal vagus nerve morphology 0.0178930344071354 0.0757076906623105 1.11337292957122 0.647058823529412 18.1 18 1 abnormal heart rate 0.0178930344071354 0.0757076906623105 1.11337292957122 0.647058823529412 18.1 18 1 abnormal duodenum morphology 0.0178930344071354 0.0757076906623105 1.11337292957122 0.647058823529412 18.1 18 1 enhanced behavioral response to cocaine 0.0178930344071354 0.0757076906623105 1.11337292957122 0.647058823529412 18.1 18 1 increased hepatoma incidence 0.0178930344071354 0.0757076906623105 1.11337292957122 0.647058823529412 18.1 18 1 decreased body fat mass 0.0178930344071354 0.0757076906623105 1.11337292957122 0.647058823529412 18.1 18 1 abnormal cell cytoskeleton morphology 0.0178930344071354 0.0757076906623105 1.11337292957122 0.647058823529412 18.1 18 1 overriding aortic valve 8.30040745870904e-05 0.000971635931931235 1.11126426871976 0.645833333333333 18.1 18 1 curly tail 8.30040745870904e-05 0.000971635931931235 1.11126426871976 0.645833333333333 18.1 18 1 abnormal myocardium layer morphology 4.81236935844194e-07 1.0754679925375e-05 1.11081050625805 0.645569620253165 18.1 18 1 increased lung adenoma incidence 0.00155557616365913 0.0110715184752563 1.11010790631734 0.645161290322581 18.1 18 1 decreased neuronal precursor cell number 0.00155557616365913 0.0110715184752563 1.11010790631734 0.645161290322581 18.1 18 1 decreased double-negative T cell number 0.00155557616365913 0.0110715184752563 1.11010790631734 0.645161290322581 18.1 18 1 abnormal podocyte morphology 0.00155557616365913 0.0110715184752563 1.11010790631734 0.645161290322581 18.1 18 1 abnormal cell migration 0.000148326376493355 0.00158693273775149 1.1088744530881 0.644444444444444 18.1 18 1 decreased bone mineral content 4.62815794547667e-16 4.42790111129739e-14 1.10850678914477 0.644230769230769 18.1 18 1 decreased grip strength 8.67573160539151e-17 9.80949198564154e-15 1.10782686267423 0.643835616438356 18.1 18 1 abnormal retinal pigmentation 1.55513513697897e-07 3.94254127046674e-06 1.10755593411891 0.64367816091954 18.1 18 1 abnormal nervous system physiology 1.71055175612897e-09 6.30369999017898e-08 1.10721197264869 0.643478260869565 18.1 18 1 decreased erythrocyte cell number 2.04563629534762e-12 1.28823298346258e-10 1.1069260683693 0.643312101910828 18.1 18 1 abnormal cartilage morphology 0.000265489751414166 0.00261546834313956 1.10614323522335 0.642857142857143 18.1 18 1 skin edema 0.000265489751414166 0.00261546834313956 1.10614323522335 0.642857142857143 18.1 18 1 abnormal pancreas morphology 0.000265489751414166 0.00261546834313956 1.10614323522335 0.642857142857143 18.1 18 1 abnormal eye development 2.62137152600039e-05 0.000362258981718109 1.10614323522335 0.642857142857143 18.1 18 1 abnormal stria vascularis morphology 0.00282449559484186 0.0181527563414596 1.10614323522335 0.642857142857143 18.1 18 1 rib bifurcation 0.00282449559484186 0.0181527563414596 1.10614323522335 0.642857142857143 18.1 18 1 myoclonus 0.00282449559484186 0.0181527563414596 1.10614323522335 0.642857142857143 18.1 18 1 shortened head 0.00282449559484186 0.0181527563414596 1.10614323522335 0.642857142857143 18.1 18 1 abnormal ovulation 0.00282449559484186 0.0181527563414596 1.10614323522335 0.642857142857143 18.1 18 1 straub tail 0.00282449559484186 0.0181527563414596 1.10614323522335 0.642857142857143 18.1 18 1 abnormal brainstem morphology 0.00282449559484186 0.0181527563414596 1.10614323522335 0.642857142857143 18.1 18 1 corneal vascularization 0.00282449559484186 0.0181527563414596 1.10614323522335 0.642857142857143 18.1 18 1 abnormal blood flow velocity 0.0337457128796986 0.120919890617561 1.10614323522335 0.642857142857143 18.1 18 1 absent atrioventricular cushions 0.0337457128796986 0.120919890617561 1.10614323522335 0.642857142857143 18.1 18 1 abnormal zigzag hair morphology 0.0337457128796986 0.120919890617561 1.10614323522335 0.642857142857143 18.1 18 1 abnormal kidney blood vessel morphology 0.0337457128796986 0.120919890617561 1.10614323522335 0.642857142857143 18.1 18 1 translucent skin 0.0337457128796986 0.120919890617561 1.10614323522335 0.642857142857143 18.1 18 1 intestinal obstruction 0.0337457128796986 0.120919890617561 1.10614323522335 0.642857142857143 18.1 18 1 failure of zygotic cell division 0.0337457128796986 0.120919890617561 1.10614323522335 0.642857142857143 18.1 18 1 abnormal vascular endothelial cell migration 0.0337457128796986 0.120919890617561 1.10614323522335 0.642857142857143 18.1 18 1 vascular smooth muscle hypoplasia 0.0337457128796986 0.120919890617561 1.10614323522335 0.642857142857143 18.1 18 1 abnormal decidualization 0.0337457128796986 0.120919890617561 1.10614323522335 0.642857142857143 18.1 18 1 premature hair loss 0.0337457128796986 0.120919890617561 1.10614323522335 0.642857142857143 18.1 18 1 abnormal glucose tolerance 0.0337457128796986 0.120919890617561 1.10614323522335 0.642857142857143 18.1 18 1 spina bifida occulta 0.0337457128796986 0.120919890617561 1.10614323522335 0.642857142857143 18.1 18 1 sternebra fusion 0.0337457128796986 0.120919890617561 1.10614323522335 0.642857142857143 18.1 18 1 pulmonary alveolar hemorrhage 0.0337457128796986 0.120919890617561 1.10614323522335 0.642857142857143 18.1 18 1 decreased response to antigen 0.0337457128796986 0.120919890617561 1.10614323522335 0.642857142857143 18.1 18 1 hemorrhage 9.35469162998965e-18 1.25782677997834e-15 1.10562023605776 0.642553191489362 18.1 18 1 decreased heart weight 4.83818125198505e-07 1.0754679925375e-05 1.10462589196516 0.641975308641975 18.1 18 1 rib fusion 4.70548952142801e-06 8.12840637816123e-05 1.10430883516494 0.641791044776119 18.1 18 1 increased circulating bilirubin level 4.66165882666198e-05 0.000593139454287554 1.10382427665894 0.641509433962264 18.1 18 1 abnormal locomotor behavior 8.86531319687354e-08 2.41364263415427e-06 1.10347139166001 0.641304347826087 18.1 18 1 increased rib number 8.53777974740692e-07 1.78468295140124e-05 1.1029918299948 0.641025641025641 18.1 18 1 abnormal response to injury 0.000476084711489638 0.00423550310586933 1.1029918299948 0.641025641025641 18.1 18 1 decreased rib number 1.56116709604412e-07 3.94254127046674e-06 1.10200037666446 0.640449438202247 18.1 18 1 decreased body size 2.86883520701151e-56 2.37874252581371e-53 1.10183078596322 0.640350877192982 18.1 18 1 abnormal hindlimb morphology 8.29866459868754e-05 0.000971635931931235 1.10122704306681 0.64 18.1 18 1 abnormal inner ear vestibule morphology 0.00515112243489103 0.0293963328327643 1.10122704306681 0.64 18.1 18 1 ruffled hair 0.00515112243489103 0.0293963328327643 1.10122704306681 0.64 18.1 18 1 mandible hypoplasia 0.00515112243489103 0.0293963328327643 1.10122704306681 0.64 18.1 18 1 decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 0.00515112243489103 0.0293963328327643 1.10122704306681 0.64 18.1 18 1 abnormal trophoblast giant cell morphology 0.000855547533502604 0.00692390385462497 1.09931519056148 0.638888888888889 18.1 18 1 abnormal lysosome morphology 0.000855547533502604 0.00692390385462497 1.09931519056148 0.638888888888889 18.1 18 1 cleft secondary palate 8.87832365930112e-08 2.41364263415427e-06 1.0982982477395 0.638297872340426 18.1 18 1 perimembraneous ventricular septal defect 4.70200151516552e-06 8.12840637816123e-05 1.09723709001222 0.63768115942029 18.1 18 1 limb grasping 1.26752024754247e-13 9.41181079331912e-12 1.09668901953768 0.637362637362637 18.1 18 1 decreased hematocrit 3.40510217970197e-11 1.7464312725791e-09 1.09604147051812 0.636986301369863 18.1 18 1 abnormal heart morphology 8.90063922247598e-17 9.840151140404e-15 1.0949700712312 0.636363636363636 18.1 18 1 abnormal joint morphology 4.64376113598577e-05 0.000593139454287554 1.0949700712312 0.636363636363636 18.1 18 1 abnormal vascular development 8.31032725846849e-06 0.000134670612739025 1.0949700712312 0.636363636363636 18.1 18 1 muscular atrophy 0.000263948852741314 0.00261546834313956 1.0949700712312 0.636363636363636 18.1 18 1 omphalocele 0.000263948852741314 0.00261546834313956 1.0949700712312 0.636363636363636 18.1 18 1 cochlear hair cell degeneration 0.000263948852741314 0.00261546834313956 1.0949700712312 0.636363636363636 18.1 18 1 dextrocardia 0.00154123567113221 0.0110644263548091 1.0949700712312 0.636363636363636 18.1 18 1 abnormal ovarian folliculogenesis 0.00154123567113221 0.0110644263548091 1.0949700712312 0.636363636363636 18.1 18 1 abnormal epidermis stratum basale morphology 0.00154123567113221 0.0110644263548091 1.0949700712312 0.636363636363636 18.1 18 1 abnormal enterocyte morphology 0.00944511818405029 0.0474558010391489 1.0949700712312 0.636363636363636 18.1 18 1 increased skin papilloma incidence 0.00944511818405029 0.0474558010391489 1.0949700712312 0.636363636363636 18.1 18 1 abnormal chorion morphology 0.00944511818405029 0.0474558010391489 1.0949700712312 0.636363636363636 18.1 18 1 increased myocardial infarction size 0.00944511818405029 0.0474558010391489 1.0949700712312 0.636363636363636 18.1 18 1 aphakia 0.00944511818405029 0.0474558010391489 1.0949700712312 0.636363636363636 18.1 18 1 abnormal cochlear sensory epithelium morphology 0.00944511818405029 0.0474558010391489 1.0949700712312 0.636363636363636 18.1 18 1 decreased cardiac output 0.00944511818405029 0.0474558010391489 1.0949700712312 0.636363636363636 18.1 18 1 abnormal occipital bone morphology 0.00944511818405029 0.0474558010391489 1.0949700712312 0.636363636363636 18.1 18 1 abnormal cerebral cortex pyramidal cell morphology 0.00944511818405029 0.0474558010391489 1.0949700712312 0.636363636363636 18.1 18 1 pulmonary vascular congestion 0.00944511818405029 0.0474558010391489 1.0949700712312 0.636363636363636 18.1 18 1 increased adenoma incidence 0.00944511818405029 0.0474558010391489 1.0949700712312 0.636363636363636 18.1 18 1 increased bone volume 0.00944511818405029 0.0474558010391489 1.0949700712312 0.636363636363636 18.1 18 1 embryonic lethality before implantation, incomplete penetrance 0.00944511818405029 0.0474558010391489 1.0949700712312 0.636363636363636 18.1 18 1 absent semicircular canals 0.0647450094008623 0.19207300045873 1.0949700712312 0.636363636363636 18.1 18 1 abnormal sphenoid bone morphology 0.0647450094008623 0.19207300045873 1.0949700712312 0.636363636363636 18.1 18 1 abnormal glossopharyngeal ganglion morphology 0.0647450094008623 0.19207300045873 1.0949700712312 0.636363636363636 18.1 18 1 focal hepatic necrosis 0.0647450094008623 0.19207300045873 1.0949700712312 0.636363636363636 18.1 18 1 abnormal bronchiole morphology 0.0647450094008623 0.19207300045873 1.0949700712312 0.636363636363636 18.1 18 1 retinal detachment 0.0647450094008623 0.19207300045873 1.0949700712312 0.636363636363636 18.1 18 1 fused joints 0.0647450094008623 0.19207300045873 1.0949700712312 0.636363636363636 18.1 18 1 loss of cortex neurons 0.0647450094008623 0.19207300045873 1.0949700712312 0.636363636363636 18.1 18 1 abnormal radial glial cell morphology 0.0647450094008623 0.19207300045873 1.0949700712312 0.636363636363636 18.1 18 1 abnormal dorsal-ventral polarity of the somites 0.0647450094008623 0.19207300045873 1.0949700712312 0.636363636363636 18.1 18 1 abnormal platelet aggregation 0.0647450094008623 0.19207300045873 1.0949700712312 0.636363636363636 18.1 18 1 abnormal superovulation 0.0647450094008623 0.19207300045873 1.0949700712312 0.636363636363636 18.1 18 1 abnormal palatal shelf elevation 0.0647450094008623 0.19207300045873 1.0949700712312 0.636363636363636 18.1 18 1 abnormal pulmonary alveolar sac morphology 0.0647450094008623 0.19207300045873 1.0949700712312 0.636363636363636 18.1 18 1 decreased core body temperature 0.0647450094008623 0.19207300045873 1.0949700712312 0.636363636363636 18.1 18 1 hypolactation 0.0647450094008623 0.19207300045873 1.0949700712312 0.636363636363636 18.1 18 1 thin hypoglossal nerve 0.0647450094008623 0.19207300045873 1.0949700712312 0.636363636363636 18.1 18 1 impaired coordination 2.65099326402084e-24 6.94141657289668e-22 1.09406588454975 0.635838150289017 18.1 18 1 infertility 1.63334243787923e-08 5.14296115724632e-07 1.09350816192381 0.635514018691589 18.1 18 1 decreased body length 1.90774025792565e-19 3.51518806784449e-17 1.09268650486784 0.635036496350365 18.1 18 1 decreased leukocyte cell number 1.82599859261394e-10 8.18409279122015e-09 1.09268650486784 0.635036496350365 18.1 18 1 decreased susceptibility to hepatic steatosis 1.46944546731335e-05 0.000218223617906983 1.09248714589961 0.634920634920635 18.1 18 1 abnormal blood vessel morphology 5.94941654954216e-11 2.93052943900715e-09 1.09173370648864 0.63448275862069 18.1 18 1 sparse hair 8.50189145702489e-07 1.78467974678054e-05 1.09115484450217 0.634146341463415 18.1 18 1 Leydig cell hyperplasia 0.00047172479339452 0.0042329904829758 1.09115484450217 0.634146341463415 18.1 18 1 lethality at weaning, incomplete penetrance 0.00047172479339452 0.0042329904829758 1.09115484450217 0.634146341463415 18.1 18 1 decreased circulating cholesterol level 2.2104030226651e-13 1.52732708857762e-11 1.09069618336535 0.633879781420765 18.1 18 1 abnormal ovary morphology 4.67773712252009e-06 8.12840637816123e-05 1.09056375303711 0.633802816901408 18.1 18 1 muscular ventricular septal defect 2.59958056098537e-05 0.000361254561198386 1.08975592803486 0.633333333333333 18.1 18 1 delayed eyelid opening 0.00278441171485277 0.0181527563414596 1.08975592803486 0.633333333333333 18.1 18 1 abnormal cellular respiration 0.00278441171485277 0.0181527563414596 1.08975592803486 0.633333333333333 18.1 18 1 abnormal placenta labyrinth morphology 1.49609011076913e-06 2.88490244227767e-05 1.08902990809613 0.632911392405063 18.1 18 1 abnormal long bone hypertrophic chondrocyte zone 0.000146553410699628 0.00157473697242041 1.08858540609282 0.63265306122449 18.1 18 1 abnormal respiratory system physiology 0.000146553410699628 0.00157473697242041 1.08858540609282 0.63265306122449 18.1 18 1 decreased circulating creatinine level 0.000146553410699628 0.00157473697242041 1.08858540609282 0.63265306122449 18.1 18 1 increased grooming behavior 0.00084443664553398 0.006921041699393 1.08673721355277 0.631578947368421 18.1 18 1 decreased neuron apoptosis 0.00084443664553398 0.006921041699393 1.08673721355277 0.631578947368421 18.1 18 1 decreased total retina thickness 0.00084443664553398 0.006921041699393 1.08673721355277 0.631578947368421 18.1 18 1 shiny skin 0.0174362103753385 0.0757076906623105 1.08673721355277 0.631578947368421 18.1 18 1 short vibrissae 0.0174362103753385 0.0757076906623105 1.08673721355277 0.631578947368421 18.1 18 1 stereotypic behavior 0.0174362103753385 0.0757076906623105 1.08673721355277 0.631578947368421 18.1 18 1 unresponsive to tactile stimuli 0.0174362103753385 0.0757076906623105 1.08673721355277 0.631578947368421 18.1 18 1 increased malignant tumor incidence 0.0174362103753385 0.0757076906623105 1.08673721355277 0.631578947368421 18.1 18 1 increased susceptibility to ischemic brain injury 0.0174362103753385 0.0757076906623105 1.08673721355277 0.631578947368421 18.1 18 1 osteoarthritis 0.0174362103753385 0.0757076906623105 1.08673721355277 0.631578947368421 18.1 18 1 right-sided stomach 0.0174362103753385 0.0757076906623105 1.08673721355277 0.631578947368421 18.1 18 1 abnormal inner ear morphology 0.000260717125604012 0.00261546834313956 1.08476848671662 0.630434782608696 18.1 18 1 abnormal allantois morphology 0.000260717125604012 0.00261546834313956 1.08476848671662 0.630434782608696 18.1 18 1 abnormal seminiferous tubule morphology 1.02841743648255e-10 4.91959302548143e-09 1.08425607836201 0.63013698630137 18.1 18 1 astrocytosis 4.63477520917151e-06 8.09052865460641e-05 1.08425607836201 0.63013698630137 18.1 18 1 abnormal osteoblast physiology 8.14907382307998e-05 0.000965277196900546 1.08338308635045 0.62962962962963 18.1 18 1 abnormal atrioventricular cushion morphology 0.00504725801318006 0.0290278555793513 1.08338308635045 0.62962962962963 18.1 18 1 abnormal brain commissure morphology 0.00504725801318006 0.0290278555793513 1.08338308635045 0.62962962962963 18.1 18 1 abnormal type II pneumocyte morphology 0.00504725801318006 0.0290278555793513 1.08338308635045 0.62962962962963 18.1 18 1 thick interventricular septum 0.00504725801318006 0.0290278555793513 1.08338308635045 0.62962962962963 18.1 18 1 pericardial effusion 2.56992874939333e-05 0.000360860749301359 1.08235520865941 0.629032258064516 18.1 18 1 thick pulmonary interalveolar septum 0.00151442111011197 0.0110472800920925 1.08156227444061 0.628571428571429 18.1 18 1 ovary cysts 0.00151442111011197 0.0110472800920925 1.08156227444061 0.628571428571429 18.1 18 1 holoprosencephaly 0.00151442111011197 0.0110472800920925 1.08156227444061 0.628571428571429 18.1 18 1 decreased triglyceride level 0.00151442111011197 0.0110472800920925 1.08156227444061 0.628571428571429 18.1 18 1 decreased circulating thyroxine level 0.00151442111011197 0.0110472800920925 1.08156227444061 0.628571428571429 18.1 18 1 decreased body weight 3.90034374411579e-80 9.70210506348803e-77 1.08132400987729 0.62843295638126 18.1 18 1 abnormal left-right axis patterning 0.000464304148345399 0.0042329904829758 1.08041897393909 0.627906976744186 18.1 18 1 decreased oxygen consumption 0.000464304148345399 0.0042329904829758 1.08041897393909 0.627906976744186 18.1 18 1 abnormal cued conditioning behavior 0.000144409583272824 0.00156182103648326 1.07963435594785 0.627450980392157 18.1 18 1 increased lung adenocarcinoma incidence 0.000144409583272824 0.00156182103648326 1.07963435594785 0.627450980392157 18.1 18 1 abnormal cervical vertebrae morphology 0.000144409583272824 0.00156182103648326 1.07963435594785 0.627450980392157 18.1 18 1 increased kidney weight 0.000144409583272824 0.00156182103648326 1.07963435594785 0.627450980392157 18.1 18 1 deafness 1.51375498128656e-07 3.88192321231991e-06 1.07758959391007 0.626262626262626 18.1 18 1 reduced fertility 5.40336286359149e-10 2.20342051199735e-08 1.07696439688413 0.62589928057554 18.1 18 1 postnatal growth retardation 4.81857177716592e-39 2.66359939904449e-36 1.0768228081459 0.625816993464052 18.1 18 1 abnormal lens morphology 2.89934165614778e-09 1.03771401002412e-07 1.07541703424493 0.625 18.1 18 1 abnormal posture 2.56686590856998e-06 4.81055622619126e-05 1.07541703424493 0.625 18.1 18 1 abnormal pancreatic beta cell morphology 0.000827826294192098 0.00681860234040677 1.07541703424493 0.625 18.1 18 1 failure of primitive streak formation 0.00272167014811803 0.0179341840885923 1.07541703424493 0.625 18.1 18 1 increased circulating follicle stimulating hormone level 0.00272167014811803 0.0179341840885923 1.07541703424493 0.625 18.1 18 1 abnormal lymphatic vessel morphology 0.00272167014811803 0.0179341840885923 1.07541703424493 0.625 18.1 18 1 abnormal depression-related behavior 0.00272167014811803 0.0179341840885923 1.07541703424493 0.625 18.1 18 1 decreased metastatic potential 0.00918570078877914 0.0473073099629153 1.07541703424493 0.625 18.1 18 1 abnormal vasodilation 0.00918570078877914 0.0473073099629153 1.07541703424493 0.625 18.1 18 1 abnormal sensory capabilities/reflexes/nociception 0.00918570078877914 0.0473073099629153 1.07541703424493 0.625 18.1 18 1 hypopigmentation 0.00918570078877914 0.0473073099629153 1.07541703424493 0.625 18.1 18 1 decreased mast cell number 0.0324700459696592 0.119391440160807 1.07541703424493 0.625 18.1 18 1 disorganized retinal layers 0.0324700459696592 0.119391440160807 1.07541703424493 0.625 18.1 18 1 abnormal extraembryonic endoderm formation 0.0324700459696592 0.119391440160807 1.07541703424493 0.625 18.1 18 1 increased intestinal adenocarcinoma incidence 0.0324700459696592 0.119391440160807 1.07541703424493 0.625 18.1 18 1 large intestinal inflammation 0.0324700459696592 0.119391440160807 1.07541703424493 0.625 18.1 18 1 small pancreas 0.0324700459696592 0.119391440160807 1.07541703424493 0.625 18.1 18 1 increased cochlear outer hair cell number 0.0324700459696592 0.119391440160807 1.07541703424493 0.625 18.1 18 1 abnormal epididymis epithelium morphology 0.0324700459696592 0.119391440160807 1.07541703424493 0.625 18.1 18 1 increased thymus weight 0.0324700459696592 0.119391440160807 1.07541703424493 0.625 18.1 18 1 abnormal level of surface class II molecules 0.0324700459696592 0.119391440160807 1.07541703424493 0.625 18.1 18 1 sepsis 0.0324700459696592 0.119391440160807 1.07541703424493 0.625 18.1 18 1 impaired behavioral response to addictive substance 0.0324700459696592 0.119391440160807 1.07541703424493 0.625 18.1 18 1 impaired somite development 0.0324700459696592 0.119391440160807 1.07541703424493 0.625 18.1 18 1 decreased liver cholesterol level 0.0324700459696592 0.119391440160807 1.07541703424493 0.625 18.1 18 1 decreased fibroblast apoptosis 0.0324700459696592 0.119391440160807 1.07541703424493 0.625 18.1 18 1 abnormal ear pigmentation 0.127539781720049 0.307879599114286 1.07541703424493 0.625 18.1 18 1 abnormal bone marrow development 0.127539781720049 0.307879599114286 1.07541703424493 0.625 18.1 18 1 absent pre-B cells 0.127539781720049 0.307879599114286 1.07541703424493 0.625 18.1 18 1 abnormal esophageal epithelium morphology 0.127539781720049 0.307879599114286 1.07541703424493 0.625 18.1 18 1 abnormal cecum morphology 0.127539781720049 0.307879599114286 1.07541703424493 0.625 18.1 18 1 absent mammary gland 0.127539781720049 0.307879599114286 1.07541703424493 0.625 18.1 18 1 abnormal hypoglossal nerve morphology 0.127539781720049 0.307879599114286 1.07541703424493 0.625 18.1 18 1 absent skin pigmentation 0.127539781720049 0.307879599114286 1.07541703424493 0.625 18.1 18 1 dermal cysts 0.127539781720049 0.307879599114286 1.07541703424493 0.625 18.1 18 1 dry eyes 0.127539781720049 0.307879599114286 1.07541703424493 0.625 18.1 18 1 unidirectional circling 0.127539781720049 0.307879599114286 1.07541703424493 0.625 18.1 18 1 poor grooming 0.127539781720049 0.307879599114286 1.07541703424493 0.625 18.1 18 1 abnormal urination 0.127539781720049 0.307879599114286 1.07541703424493 0.625 18.1 18 1 abnormal atrial thrombosis 0.127539781720049 0.307879599114286 1.07541703424493 0.625 18.1 18 1 abnormal secondary sex determination 0.127539781720049 0.307879599114286 1.07541703424493 0.625 18.1 18 1 decreased aerobic running capacity 0.127539781720049 0.307879599114286 1.07541703424493 0.625 18.1 18 1 decreased susceptibility to age related obesity 0.127539781720049 0.307879599114286 1.07541703424493 0.625 18.1 18 1 increased cardiac output 0.127539781720049 0.307879599114286 1.07541703424493 0.625 18.1 18 1 hair follicle degeneration 0.127539781720049 0.307879599114286 1.07541703424493 0.625 18.1 18 1 abnormal ovary development 0.127539781720049 0.307879599114286 1.07541703424493 0.625 18.1 18 1 abnormal lateral ganglionic eminence morphology 0.127539781720049 0.307879599114286 1.07541703424493 0.625 18.1 18 1 bowed fibula 0.127539781720049 0.307879599114286 1.07541703424493 0.625 18.1 18 1 absent interparietal bone 0.127539781720049 0.307879599114286 1.07541703424493 0.625 18.1 18 1 absent cochlear microphonics 0.127539781720049 0.307879599114286 1.07541703424493 0.625 18.1 18 1 increased epididymis weight 0.127539781720049 0.307879599114286 1.07541703424493 0.625 18.1 18 1 abnormal NK cell morphology 0.127539781720049 0.307879599114286 1.07541703424493 0.625 18.1 18 1 abnormal somite size 0.127539781720049 0.307879599114286 1.07541703424493 0.625 18.1 18 1 ectrodactyly 0.127539781720049 0.307879599114286 1.07541703424493 0.625 18.1 18 1 ocular hypertension 0.127539781720049 0.307879599114286 1.07541703424493 0.625 18.1 18 1 stomach epithelial hyperplasia 0.127539781720049 0.307879599114286 1.07541703424493 0.625 18.1 18 1 increased pulmonary ventilation 0.127539781720049 0.307879599114286 1.07541703424493 0.625 18.1 18 1 hypergranulosis 0.127539781720049 0.307879599114286 1.07541703424493 0.625 18.1 18 1 abnormal epidermal lamellar body morphology 0.127539781720049 0.307879599114286 1.07541703424493 0.625 18.1 18 1 enlarged inguinal lymph nodes 0.127539781720049 0.307879599114286 1.07541703424493 0.625 18.1 18 1 abnormal meiotic spindle morphology 0.127539781720049 0.307879599114286 1.07541703424493 0.625 18.1 18 1 abnormal frontonasal prominence morphology 0.127539781720049 0.307879599114286 1.07541703424493 0.625 18.1 18 1 increased caudal vertebrae number 0.127539781720049 0.307879599114286 1.07541703424493 0.625 18.1 18 1 abnormal lateral plate mesoderm morphology 0.127539781720049 0.307879599114286 1.07541703424493 0.625 18.1 18 1 abnormal brain ependyma morphology 0.127539781720049 0.307879599114286 1.07541703424493 0.625 18.1 18 1 decreased quadriceps weight 0.127539781720049 0.307879599114286 1.07541703424493 0.625 18.1 18 1 heart right ventricle hypoplasia 0.127539781720049 0.307879599114286 1.07541703424493 0.625 18.1 18 1 abnormal hepatic vein morphology 0.127539781720049 0.307879599114286 1.07541703424493 0.625 18.1 18 1 anomalous pulmonary venous connection 0.127539781720049 0.307879599114286 1.07541703424493 0.625 18.1 18 1 delayed suture closure 0.127539781720049 0.307879599114286 1.07541703424493 0.625 18.1 18 1 abnormal visual evoked potential 0.127539781720049 0.307879599114286 1.07541703424493 0.625 18.1 18 1 decreased alveolar lamellar body number 0.127539781720049 0.307879599114286 1.07541703424493 0.625 18.1 18 1 decreased lung compliance 0.127539781720049 0.307879599114286 1.07541703424493 0.625 18.1 18 1 abnormal bronchiole epithelium morphology 0.127539781720049 0.307879599114286 1.07541703424493 0.625 18.1 18 1 abnormal pulmonary acinus morphology 0.127539781720049 0.307879599114286 1.07541703424493 0.625 18.1 18 1 abnormal branching involved in ureteric bud morphogenesis 0.127539781720049 0.307879599114286 1.07541703424493 0.625 18.1 18 1 abnormal kidney mesenchyme morphology 0.127539781720049 0.307879599114286 1.07541703424493 0.625 18.1 18 1 increased aorta wall thickness 0.127539781720049 0.307879599114286 1.07541703424493 0.625 18.1 18 1 increased circulating lactate level 0.127539781720049 0.307879599114286 1.07541703424493 0.625 18.1 18 1 increased testis apoptosis 0.127539781720049 0.307879599114286 1.07541703424493 0.625 18.1 18 1 retropleural edema 0.127539781720049 0.307879599114286 1.07541703424493 0.625 18.1 18 1 embryo cyst 0.127539781720049 0.307879599114286 1.07541703424493 0.625 18.1 18 1 premature death 9.83470499790621e-54 6.98966533779762e-51 1.07316877563675 0.623693379790941 18.1 18 1 decreased circulating glucose level 2.83167809233039e-18 4.26896924525566e-16 1.0731043094401 0.623655913978495 18.1 18 1 lethargy 4.62925778489867e-07 1.05162362921785e-05 1.0731043094401 0.623655913978495 18.1 18 1 postnatal lethality, incomplete penetrance 1.23313599584344e-35 5.57713779938283e-33 1.07238769048649 0.623239436619718 18.1 18 1 neonatal lethality, incomplete penetrance 4.61447516252399e-17 5.73925348338922e-15 1.07210805875494 0.623076923076923 18.1 18 1 increased or absent threshold for auditory brainstem response 9.11047865259601e-19 1.51082104322217e-16 1.07169586803647 0.622837370242215 18.1 18 1 decreased birth body size 2.71814171048046e-08 8.34737963558044e-07 1.07164364114231 0.62280701754386 18.1 18 1 abnormal pancreatic islet morphology 0.000141600693560664 0.00154827131970177 1.07135885675721 0.622641509433962 18.1 18 1 respiratory failure 1.7082863926429e-10 7.72611345763492e-09 1.0711438539764 0.622516556291391 18.1 18 1 abnormal angiogenesis 7.89128772602446e-06 0.000128297896852849 1.06960396919495 0.621621621621622 18.1 18 1 increased granulocyte number 7.89128772602446e-06 0.000128297896852849 1.06960396919495 0.621621621621622 18.1 18 1 malocclusion 0.00147784109441343 0.0109083968022356 1.06960396919495 0.621621621621622 18.1 18 1 abnormal breathing pattern 0.00147784109441343 0.0109083968022356 1.06960396919495 0.621621621621622 18.1 18 1 abnormal glucose homeostasis 3.29429947892125e-12 2.02335060588065e-10 1.06832637248068 0.620879120879121 18.1 18 1 enlarged heart 3.92681327519219e-15 3.36825793863468e-13 1.06800036504324 0.620689655172414 18.1 18 1 increased blood urea nitrogen level 5.16155014292426e-10 2.13989266342068e-08 1.06800036504324 0.620689655172414 18.1 18 1 thrombocytosis 7.84796004835873e-05 0.000940809668447823 1.06800036504324 0.620689655172414 18.1 18 1 lordosis 0.0049029909220677 0.0286276425121068 1.06800036504324 0.620689655172414 18.1 18 1 decreased granulocyte number 0.0049029909220677 0.0286276425121068 1.06800036504324 0.620689655172414 18.1 18 1 abnormal embryonic erythropoiesis 0.0049029909220677 0.0286276425121068 1.06800036504324 0.620689655172414 18.1 18 1 abnormal liver morphology 5.7167474333357e-12 3.4266046362464e-10 1.06700595129553 0.620111731843575 18.1 18 1 decreased oocyte number 0.000250267605757275 0.00253580720701108 1.06681369797097 0.62 18.1 18 1 kinked tail 2.50313589934491e-07 6.10446132315731e-06 1.06276506913616 0.617647058823529 18.1 18 1 overexpanded pulmonary alveoli 0.00264191942545747 0.0175247321888679 1.06276506913616 0.617647058823529 18.1 18 1 increased susceptibility to viral infection induced morbidity/mortality 0.00264191942545747 0.0175247321888679 1.06276506913616 0.617647058823529 18.1 18 1 abnormal eating behavior 7.65522649970032e-05 0.000922148954867049 1.06107814045499 0.616666666666667 18.1 18 1 abnormal motor coordination/ balance 4.35608779883475e-07 9.98688331760502e-06 1.06020911658894 0.616161616161616 18.1 18 1 increased urine protein level 7.5357947533576e-06 0.000124968596326513 1.05887215679501 0.615384615384615 18.1 18 1 abnormal heart looping 0.00143379974000493 0.0106306314553272 1.05887215679501 0.615384615384615 18.1 18 1 abnormal kidney cortex morphology 0.00885673608273627 0.0463325573203081 1.05887215679501 0.615384615384615 18.1 18 1 pulmonary edema 0.00885673608273627 0.0463325573203081 1.05887215679501 0.615384615384615 18.1 18 1 absent common myeloid progenitor cells 0.0611734475609821 0.19207300045873 1.05887215679501 0.615384615384615 18.1 18 1 abnormal sympathetic ganglion morphology 0.0611734475609821 0.19207300045873 1.05887215679501 0.615384615384615 18.1 18 1 increased pituitary adenoma incidence 0.0611734475609821 0.19207300045873 1.05887215679501 0.615384615384615 18.1 18 1 lymphoid hypoplasia 0.0611734475609821 0.19207300045873 1.05887215679501 0.615384615384615 18.1 18 1 abnormal pulmonary alveolus epithelial cell morphology 0.0611734475609821 0.19207300045873 1.05887215679501 0.615384615384615 18.1 18 1 abnormal coping response 0.0611734475609821 0.19207300045873 1.05887215679501 0.615384615384615 18.1 18 1 abnormal telomere length 0.0611734475609821 0.19207300045873 1.05887215679501 0.615384615384615 18.1 18 1 tracheoesophageal fistula 0.0611734475609821 0.19207300045873 1.05887215679501 0.615384615384615 18.1 18 1 increased cochlear inner hair cell number 0.0611734475609821 0.19207300045873 1.05887215679501 0.615384615384615 18.1 18 1 small pituitary gland 0.0611734475609821 0.19207300045873 1.05887215679501 0.615384615384615 18.1 18 1 increased prostaglandin level 0.0611734475609821 0.19207300045873 1.05887215679501 0.615384615384615 18.1 18 1 abnormal aorta tunica media morphology 0.0611734475609821 0.19207300045873 1.05887215679501 0.615384615384615 18.1 18 1 domed cranium 2.36174412729732e-05 0.000338607407299831 1.05698131365787 0.614285714285714 18.1 18 1 abnormal motor capabilities/coordination/movement 7.93796538752023e-09 2.68648828591246e-07 1.05586399725866 0.613636363636364 18.1 18 1 osteoporosis 0.000782515500187178 0.00662077315209389 1.05586399725866 0.613636363636364 18.1 18 1 impaired glucose tolerance 3.31747295347345e-15 2.89551367430358e-13 1.05460251100148 0.612903225806452 18.1 18 1 abnormal nose morphology 0.00473006800424272 0.0282837600013312 1.05460251100148 0.612903225806452 18.1 18 1 abnormal capillary morphology 0.00473006800424272 0.0282837600013312 1.05460251100148 0.612903225806452 18.1 18 1 decreased thymus weight 0.00473006800424272 0.0282837600013312 1.05460251100148 0.612903225806452 18.1 18 1 inner cell mass degeneration 0.00473006800424272 0.0282837600013312 1.05460251100148 0.612903225806452 18.1 18 1 small cranium 0.00473006800424272 0.0282837600013312 1.05460251100148 0.612903225806452 18.1 18 1 respiratory distress 4.81390140455073e-11 2.39491594876399e-09 1.05428167056613 0.61271676300578 18.1 18 1 small testis 1.10781090551896e-16 1.17262962871422e-14 1.05359697847764 0.61231884057971 18.1 18 1 organ of Corti degeneration 0.000428997205022147 0.00397441544689978 1.05346974783177 0.612244897959184 18.1 18 1 increased sarcoma incidence 0.000428997205022147 0.00397441544689978 1.05346974783177 0.612244897959184 18.1 18 1 abnormal lung development 4.09462225860651e-06 7.30134255790945e-05 1.05264349704915 0.611764705882353 18.1 18 1 circling 4.09462225860651e-06 7.30134255790945e-05 1.05264349704915 0.611764705882353 18.1 18 1 increased heart weight 4.35578597019841e-09 1.50486355567619e-07 1.05220659465691 0.611510791366906 18.1 18 1 abnormal enzyme/coenzyme activity 4.51183437301821e-10 1.9022352547259e-08 1.052127748153 0.611464968152866 18.1 18 1 decreased insulin secretion 2.28869730841577e-06 4.31298072324562e-05 1.05151887792837 0.611111111111111 18.1 18 1 decreased platelet aggregation 0.000236059194793308 0.00241644957633067 1.05151887792837 0.611111111111111 18.1 18 1 abnormal megakaryocyte differentiation 0.0309011144073765 0.11898842428537 1.05151887792837 0.611111111111111 18.1 18 1 right pulmonary isomerism 0.0309011144073765 0.11898842428537 1.05151887792837 0.611111111111111 18.1 18 1 abnormal phrenic nerve morphology 0.0309011144073765 0.11898842428537 1.05151887792837 0.611111111111111 18.1 18 1 abnormal white adipose tissue morphology 0.0309011144073765 0.11898842428537 1.05151887792837 0.611111111111111 18.1 18 1 absent allantois 0.0309011144073765 0.11898842428537 1.05151887792837 0.611111111111111 18.1 18 1 darkened coat color 0.0309011144073765 0.11898842428537 1.05151887792837 0.611111111111111 18.1 18 1 primary atelectasis 0.0309011144073765 0.11898842428537 1.05151887792837 0.611111111111111 18.1 18 1 increased effector memory CD4-positive, alpha-beta T cell number 0.0309011144073765 0.11898842428537 1.05151887792837 0.611111111111111 18.1 18 1 abnormal metanephric mesenchyme morphology 0.0309011144073765 0.11898842428537 1.05151887792837 0.611111111111111 18.1 18 1 abnormal hypoglossal nerve topology 0.0309011144073765 0.11898842428537 1.05151887792837 0.611111111111111 18.1 18 1 alopecia 1.28053548414684e-06 2.52804128318671e-05 1.05051263976768 0.610526315789474 18.1 18 1 increased inflammatory response 1.28053548414684e-06 2.52804128318671e-05 1.05051263976768 0.610526315789474 18.1 18 1 decreased birth weight 1.28053548414684e-06 2.52804128318671e-05 1.05051263976768 0.610526315789474 18.1 18 1 azoospermia 4.39045640811434e-10 1.86688210515973e-08 1.04971524348939 0.610062893081761 18.1 18 1 decreased double-positive T cell number 7.17097495115296e-07 1.52459830692248e-05 1.04960702542305 0.61 18.1 18 1 thick ventricular wall 0.0013842348891883 0.0103246905153101 1.04918735048286 0.609756097560976 18.1 18 1 liver fibrosis 0.0013842348891883 0.0103246905153101 1.04918735048286 0.609756097560976 18.1 18 1 increased tumor growth/size 0.0013842348891883 0.0103246905153101 1.04918735048286 0.609756097560976 18.1 18 1 increased bone trabecula number 0.0013842348891883 0.0103246905153101 1.04918735048286 0.609756097560976 18.1 18 1 increased sacral vertebrae number 7.21041432224512e-05 0.000877061399832995 1.0485316083888 0.609375 18.1 18 1 short limbs 3.97396566117138e-06 7.19197818429909e-05 1.0482225805054 0.609195402298851 18.1 18 1 thymus hypoplasia 7.31302719662354e-09 2.5091248484967e-07 1.04736267682984 0.608695652173913 18.1 18 1 atrial septal defect 0.000755648367528009 0.00644828581209579 1.04736267682984 0.608695652173913 18.1 18 1 hypotension 0.0160490190443395 0.0725853361323536 1.04736267682984 0.608695652173913 18.1 18 1 decreased epididymis weight 0.0160490190443395 0.0725853361323536 1.04736267682984 0.608695652173913 18.1 18 1 abnormal B cell morphology 0.0160490190443395 0.0725853361323536 1.04736267682984 0.608695652173913 18.1 18 1 abnormal ulna morphology 0.0160490190443395 0.0725853361323536 1.04736267682984 0.608695652173913 18.1 18 1 abnormal hepatocyte physiology 0.0160490190443395 0.0725853361323536 1.04736267682984 0.608695652173913 18.1 18 1 decreased effector memory CD8-positive, alpha-beta T cell number 0.0160490190443395 0.0725853361323536 1.04736267682984 0.608695652173913 18.1 18 1 impaired hematopoiesis 0.000414347540608173 0.00386026032682708 1.04589578232448 0.607843137254902 18.1 18 1 abnormal dendritic spine morphology 0.000414347540608173 0.00386026032682708 1.04589578232448 0.607843137254902 18.1 18 1 enlarged spleen 9.39313818829631e-17 1.01588831492987e-14 1.04554433884923 0.607638888888889 18.1 18 1 abnormal rib morphology 1.26132215409954e-08 4.10135798473545e-07 1.04514603624396 0.607407407407407 18.1 18 1 absent corpus callosum 0.0084824362960663 0.0445148951191243 1.0446908332665 0.607142857142857 18.1 18 1 failure of blastocyst to hatch from the zona pellucida 0.0084824362960663 0.0445148951191243 1.0446908332665 0.607142857142857 18.1 18 1 abnormal neuron morphology 1.2029031462882e-06 2.41308191644509e-05 1.04282863926781 0.606060606060606 18.1 18 1 abnormal tooth development 0.0045377231896347 0.0273638459011305 1.04282863926781 0.606060606060606 18.1 18 1 increased osteoblast cell number 0.0045377231896347 0.0273638459011305 1.04282863926781 0.606060606060606 18.1 18 1 abnormal kidney morphology 1.27551168849037e-10 5.98648174550907e-09 1.04223273718823 0.605714285714286 18.1 18 1 increased bone marrow cell number 0.00244906124936192 0.0164754424398582 1.0414564963214 0.605263157894737 18.1 18 1 abnormal homeostasis 0.00133076069513889 0.00998572316488078 1.04040345638579 0.604651162790698 18.1 18 1 abnormal B cell differentiation 3.7196324909418e-06 6.80337192736597e-05 1.03996372542367 0.604395604395604 18.1 18 1 abnormal hepatocyte morphology 3.64734340479941e-07 8.59977888098439e-06 1.0386009555951 0.603603603603604 18.1 18 1 glomerulosclerosis 0.00021960520055362 0.00226197903261751 1.03833368823648 0.603448275862069 18.1 18 1 cataract 1.14751500736068e-07 3.02057521778804e-06 1.03808850908932 0.603305785123967 18.1 18 1 short tail 1.15284055411252e-05 0.000182075611324121 1.03654653903126 0.602409638554217 18.1 18 1 hyperglycemia 6.42770006150624e-06 0.000108768053761883 1.03631096027238 0.602272727272727 18.1 18 1 abnormal gait 4.09726301856491e-17 5.22663679932319e-15 1.03574145434075 0.601941747572815 18.1 18 1 abnormal retina morphology 6.12759146418323e-12 3.54474041096646e-10 1.03240035287513 0.6 18.1 18 1 abnormal contextual conditioning behavior 0.000382782857236211 0.00360671347490558 1.03240035287513 0.6 18.1 18 1 abnormal rostral-caudal axis patterning 0.000382782857236211 0.00360671347490558 1.03240035287513 0.6 18.1 18 1 albuminuria 0.0012747099418022 0.00972650607433425 1.03240035287513 0.6 18.1 18 1 lethality at weaning, complete penetrance 0.0012747099418022 0.00972650607433425 1.03240035287513 0.6 18.1 18 1 abnormal dermal layer morphology 0.00433316689847572 0.0264834217689394 1.03240035287513 0.6 18.1 18 1 increased circulating serum albumin level 0.00433316689847572 0.0264834217689394 1.03240035287513 0.6 18.1 18 1 impaired adaptive thermogenesis 0.00433316689847572 0.0264834217689394 1.03240035287513 0.6 18.1 18 1 abnormal hair cycle 0.0080808597328901 0.0427693550423961 1.03240035287513 0.6 18.1 18 1 abnormal lactation 0.0080808597328901 0.0427693550423961 1.03240035287513 0.6 18.1 18 1 emphysema 0.0080808597328901 0.0427693550423961 1.03240035287513 0.6 18.1 18 1 abnormal microglial cell physiology 0.0080808597328901 0.0427693550423961 1.03240035287513 0.6 18.1 18 1 liver hemorrhage 0.0080808597328901 0.0427693550423961 1.03240035287513 0.6 18.1 18 1 abnormal fat pad morphology 0.0080808597328901 0.0427693550423961 1.03240035287513 0.6 18.1 18 1 abnormal thyroid gland morphology 0.0152375683196113 0.0695403633184721 1.03240035287513 0.6 18.1 18 1 diaphragmatic hernia 0.0152375683196113 0.0695403633184721 1.03240035287513 0.6 18.1 18 1 increased liver glycogen level 0.0152375683196113 0.0695403633184721 1.03240035287513 0.6 18.1 18 1 abnormal pericardium morphology 0.0291865779988139 0.11335146412498 1.03240035287513 0.6 18.1 18 1 abnormal cell proliferation 0.0291865779988139 0.11335146412498 1.03240035287513 0.6 18.1 18 1 abnormal hearing physiology 0.0291865779988139 0.11335146412498 1.03240035287513 0.6 18.1 18 1 decreased paired-pulse facilitation 0.0291865779988139 0.11335146412498 1.03240035287513 0.6 18.1 18 1 abnormal hyoid bone morphology 0.0291865779988139 0.11335146412498 1.03240035287513 0.6 18.1 18 1 absent placental labyrinth 0.0291865779988139 0.11335146412498 1.03240035287513 0.6 18.1 18 1 kidney atrophy 0.0291865779988139 0.11335146412498 1.03240035287513 0.6 18.1 18 1 increased urine calcium level 0.0291865779988139 0.11335146412498 1.03240035287513 0.6 18.1 18 1 decreased muscle cell glucose uptake 0.0291865779988139 0.11335146412498 1.03240035287513 0.6 18.1 18 1 interdigital webbing 0.0572632496244575 0.181570852059704 1.03240035287513 0.6 18.1 18 1 abnormal prostate gland morphology 0.0572632496244575 0.181570852059704 1.03240035287513 0.6 18.1 18 1 increased airway responsiveness 0.0572632496244575 0.181570852059704 1.03240035287513 0.6 18.1 18 1 abnormal respiratory system morphology 0.0572632496244575 0.181570852059704 1.03240035287513 0.6 18.1 18 1 abnormal bronchus morphology 0.0572632496244575 0.181570852059704 1.03240035287513 0.6 18.1 18 1 abnormal Muller cell morphology 0.0572632496244575 0.181570852059704 1.03240035287513 0.6 18.1 18 1 abnormal coronary vessel morphology 0.0572632496244575 0.181570852059704 1.03240035287513 0.6 18.1 18 1 abnormal branching involved in lung morphogenesis 0.0572632496244575 0.181570852059704 1.03240035287513 0.6 18.1 18 1 absent maxillary shelf 0.117135595791687 0.307879599114286 1.03240035287513 0.6 18.1 18 1 abnormal immune cell physiology 0.117135595791687 0.307879599114286 1.03240035287513 0.6 18.1 18 1 rhinitis 0.117135595791687 0.307879599114286 1.03240035287513 0.6 18.1 18 1 decreased circulating parathyroid hormone level 0.117135595791687 0.307879599114286 1.03240035287513 0.6 18.1 18 1 abnormal primordial germ cell migration 0.117135595791687 0.307879599114286 1.03240035287513 0.6 18.1 18 1 primary sex reversal 0.117135595791687 0.307879599114286 1.03240035287513 0.6 18.1 18 1 abnormal tibialis anterior morphology 0.117135595791687 0.307879599114286 1.03240035287513 0.6 18.1 18 1 abnormal scala media morphology 0.117135595791687 0.307879599114286 1.03240035287513 0.6 18.1 18 1 intestinal edema 0.117135595791687 0.307879599114286 1.03240035287513 0.6 18.1 18 1 peritoneal inflammation 0.117135595791687 0.307879599114286 1.03240035287513 0.6 18.1 18 1 absent CD4-positive, alpha beta T cells 0.117135595791687 0.307879599114286 1.03240035287513 0.6 18.1 18 1 abnormal pillar cell morphology 0.117135595791687 0.307879599114286 1.03240035287513 0.6 18.1 18 1 absent pharyngeal arches 0.117135595791687 0.307879599114286 1.03240035287513 0.6 18.1 18 1 increased heart rate variability 0.117135595791687 0.307879599114286 1.03240035287513 0.6 18.1 18 1 abnormal plasma membrane morphology 0.117135595791687 0.307879599114286 1.03240035287513 0.6 18.1 18 1 abnormal placental transport 0.117135595791687 0.307879599114286 1.03240035287513 0.6 18.1 18 1 abnormal deltoid tuberosity morphology 0.117135595791687 0.307879599114286 1.03240035287513 0.6 18.1 18 1 decreased cochlear inner hair cell number 0.117135595791687 0.307879599114286 1.03240035287513 0.6 18.1 18 1 abnormal corneal endothelium morphology 0.117135595791687 0.307879599114286 1.03240035287513 0.6 18.1 18 1 tachypnea 0.117135595791687 0.307879599114286 1.03240035287513 0.6 18.1 18 1 decreased thyroxine level 0.117135595791687 0.307879599114286 1.03240035287513 0.6 18.1 18 1 abnormal developmental vascular remodeling 0.117135595791687 0.307879599114286 1.03240035287513 0.6 18.1 18 1 thick aortic valve cusps 0.117135595791687 0.307879599114286 1.03240035287513 0.6 18.1 18 1 thick aortic valve 0.117135595791687 0.307879599114286 1.03240035287513 0.6 18.1 18 1 reduced female fertility 5.97996426385157e-13 3.96670962835488e-11 1.03091701903479 0.599137931034483 18.1 18 1 abnormal neuromuscular synapse morphology 6.19273889719351e-05 0.000764488238549323 1.02762072161182 0.597222222222222 18.1 18 1 cochlear outer hair cell degeneration 6.19273889719351e-05 0.000764488238549323 1.02762072161182 0.597222222222222 18.1 18 1 abnormal cranium morphology 5.55159872752314e-08 1.58731055571423e-06 1.02726403271157 0.597014925373134 18.1 18 1 decreased white adipose tissue amount 0.000111730283654051 0.00127490403940116 1.02726403271157 0.597014925373134 18.1 18 1 increased macrophage cell number 0.000366383808105347 0.00346532213939944 1.02636292391095 0.596491228070175 18.1 18 1 abnormal vertebrae morphology 9.98695812591899e-07 2.05500387735503e-05 1.02608597762819 0.596330275229358 18.1 18 1 abnormal skin condition 0.000666507532595021 0.0057170258183797 1.02578240189516 0.596153846153846 18.1 18 1 increased mean corpuscular hemoglobin 3.18908882125879e-06 5.89803601701207e-05 1.02544816194668 0.595959595959596 18.1 18 1 postnatal lethality, complete penetrance 4.97064752385963e-20 9.89158857248066e-18 1.0252680533734 0.595854922279793 18.1 18 1 abnormal optic nerve morphology 0.00223332040768201 0.0151994104353188 1.02420669928088 0.595238095238095 18.1 18 1 abnormal response to infection 3.29507326644895e-05 0.000444254458010394 1.02368811361036 0.594936708860759 18.1 18 1 abnormal pancreatic beta cell physiology 0.00412199128246996 0.0254428121963872 1.02309944879517 0.594594594594595 18.1 18 1 decreased lymphocyte cell number 1.62124275208233e-07 4.0328413458048e-06 1.02164618253268 0.59375 18.1 18 1 decreased caudal vertebrae number 0.00019313684906456 0.00200178296686706 1.02164618253268 0.59375 18.1 18 1 abnormal vertebral body morphology 0.00766541871704033 0.0412275222889466 1.02164618253268 0.59375 18.1 18 1 scoliosis 0.00766541871704033 0.0412275222889466 1.02164618253268 0.59375 18.1 18 1 abnormal spongiotrophoblast layer morphology 0.00766541871704033 0.0412275222889466 1.02164618253268 0.59375 18.1 18 1 increased hemoglobin content 0.000349850302726562 0.00334070106730258 1.02073481216468 0.593220338983051 18.1 18 1 abnormal skeleton development 3.15149444334051e-05 0.000429553009742987 1.0196546695063 0.592592592592593 18.1 18 1 abnormal mandible morphology 0.000635635495102163 0.00550921008385585 1.0196546695063 0.592592592592593 18.1 18 1 abnormal small intestine morphology 0.000635635495102163 0.00550921008385585 1.0196546695063 0.592592592592593 18.1 18 1 decreased tumor growth/size 0.000635635495102163 0.00550921008385585 1.0196546695063 0.592592592592593 18.1 18 1 thin epidermis 0.0143977950929999 0.0675456121583979 1.0196546695063 0.592592592592593 18.1 18 1 abnormal palate morphology 0.0143977950929999 0.0675456121583979 1.0196546695063 0.592592592592593 18.1 18 1 abnormal lipid homeostasis 1.55324445286256e-07 3.94254127046674e-06 1.01916445091519 0.592307692307692 18.1 18 1 decreased B cell number 4.41943613980781e-11 2.22087826217615e-09 1.01903594701267 0.592233009708738 18.1 18 1 abnormal axial skeleton morphology 5.66665163135024e-05 0.000706556187116978 1.01881613770572 0.592105263157895 18.1 18 1 abnormal spleen morphology 1.43418695948829e-09 5.40536372988959e-08 1.01855590369864 0.591954022988506 18.1 18 1 abnormal skeletal muscle fiber morphology 0.000102072795547916 0.00116738427092157 1.01785950283464 0.591549295774648 18.1 18 1 abnormal tail morphology 0.000184240448219069 0.00191356206657592 1.01675792328611 0.590909090909091 18.1 18 1 abnormal long bone epiphysis morphology 0.0274192227895034 0.109478026031598 1.01675792328611 0.590909090909091 18.1 18 1 increased body size 0.0274192227895034 0.109478026031598 1.01675792328611 0.590909090909091 18.1 18 1 testis hypoplasia 0.0274192227895034 0.109478026031598 1.01675792328611 0.590909090909091 18.1 18 1 abnormal tracheal cartilage morphology 0.0274192227895034 0.109478026031598 1.01675792328611 0.590909090909091 18.1 18 1 abnormal limb posture 0.0274192227895034 0.109478026031598 1.01675792328611 0.590909090909091 18.1 18 1 cleft upper lip 0.0274192227895034 0.109478026031598 1.01675792328611 0.590909090909091 18.1 18 1 decreased circulating estradiol level 0.0274192227895034 0.109478026031598 1.01675792328611 0.590909090909091 18.1 18 1 abnormal temporal bone morphology 0.0274192227895034 0.109478026031598 1.01675792328611 0.590909090909091 18.1 18 1 failure of palatal shelf elevation 0.0274192227895034 0.109478026031598 1.01675792328611 0.590909090909091 18.1 18 1 rough coat 0.0274192227895034 0.109478026031598 1.01675792328611 0.590909090909091 18.1 18 1 reduced male fertility 6.98081371203596e-12 3.9919020939516e-10 1.01572428256437 0.590308370044053 18.1 18 1 decreased bone mineral density 1.17100857347128e-13 8.82692068639333e-12 1.01558180076062 0.590225563909774 18.1 18 1 abnormal maternal nurturing 0.000333346511356004 0.00318922864230023 1.01547575692636 0.590163934426229 18.1 18 1 abnormal cornea morphology 5.40659223458767e-05 0.000675824029323458 1.01475248359521 0.58974358974359 18.1 18 1 increased circulating alanine transaminase level 5.40659223458767e-05 0.000675824029323458 1.01475248359521 0.58974358974359 18.1 18 1 absent gastric milk in neonates 5.40659223458767e-05 0.000675824029323458 1.01475248359521 0.58974358974359 18.1 18 1 acanthosis 0.0039084996690626 0.0243059823169831 1.01475248359521 0.58974358974359 18.1 18 1 ataxia 1.21772303806247e-10 5.76968772796268e-09 1.01366041247641 0.589108910891089 18.1 18 1 hypoactivity 1.57870371077709e-18 2.45439092534875e-16 1.01323111555384 0.588859416445623 18.1 18 1 male infertility 3.66552426530741e-24 9.11799160995219e-22 1.01255965689542 0.588469184890656 18.1 18 1 cochlear inner hair cell degeneration 0.00110101169436415 0.00859895318596802 1.01215720870111 0.588235294117647 18.1 18 1 distended urinary bladder 0.0532943482018361 0.17017932111947 1.01215720870111 0.588235294117647 18.1 18 1 hyperlipidemia 0.0532943482018361 0.17017932111947 1.01215720870111 0.588235294117647 18.1 18 1 absence seizures 0.0532943482018361 0.17017932111947 1.01215720870111 0.588235294117647 18.1 18 1 abnormal tarsal bone morphology 0.0532943482018361 0.17017932111947 1.01215720870111 0.588235294117647 18.1 18 1 increased circulating magnesium level 0.0532943482018361 0.17017932111947 1.01215720870111 0.588235294117647 18.1 18 1 increased trabecular bone mass 0.0532943482018361 0.17017932111947 1.01215720870111 0.588235294117647 18.1 18 1 delayed heart development 0.0532943482018361 0.17017932111947 1.01215720870111 0.588235294117647 18.1 18 1 abnormal spermatogenesis 1.14672408591222e-09 4.388424867241e-08 1.00995686694306 0.58695652173913 18.1 18 1 improved glucose tolerance 3.48779234851305e-10 1.50884929859586e-08 1.00957517500544 0.586734693877551 18.1 18 1 abnormal neurocranium morphology 9.25949932077091e-05 0.00107630862431858 1.00945812281124 0.586666666666667 18.1 18 1 cachexia 4.54677070321989e-06 8.0498876329249e-05 1.00923752444524 0.586538461538462 18.1 18 1 abnormal spermiogenesis 0.000574320168803625 0.00500392791558325 1.00866701142973 0.586206896551724 18.1 18 1 abnormal enzyme/coenzyme level 0.000574320168803625 0.00500392791558325 1.00866701142973 0.586206896551724 18.1 18 1 abnormal microglial cell morphology 0.0135533172425644 0.0638520390925736 1.00866701142973 0.586206896551724 18.1 18 1 impaired fertilization 0.000166760645847669 0.00175759472182009 1.00781939209239 0.585714285714286 18.1 18 1 dehydration 0.000166760645847669 0.00175759472182009 1.00781939209239 0.585714285714286 18.1 18 1 abnormal placenta development 0.00104366197760297 0.00821553534584613 1.00642801695374 0.584905660377358 18.1 18 1 increased startle reflex 2.59797865398159e-05 0.000361254561198386 1.00533367695706 0.584269662921348 18.1 18 1 cyanosis 9.47378378703672e-10 3.68219330785216e-08 1.00372256529527 0.583333333333333 18.1 18 1 abnormal kidney physiology 0.00190345507073213 0.0133001249675454 1.00372256529527 0.583333333333333 18.1 18 1 abnormal hair shaft morphology 0.00190345507073213 0.0133001249675454 1.00372256529527 0.583333333333333 18.1 18 1 abnormal phalanx morphology 0.00190345507073213 0.0133001249675454 1.00372256529527 0.583333333333333 18.1 18 1 abnormal foregut morphology 0.025657664602124 0.104286667806836 1.00372256529527 0.583333333333333 18.1 18 1 decreased body height 0.025657664602124 0.104286667806836 1.00372256529527 0.583333333333333 18.1 18 1 curly vibrissae 0.025657664602124 0.104286667806836 1.00372256529527 0.583333333333333 18.1 18 1 small lymph nodes 0.025657664602124 0.104286667806836 1.00372256529527 0.583333333333333 18.1 18 1 prolonged QT interval 0.025657664602124 0.104286667806836 1.00372256529527 0.583333333333333 18.1 18 1 abnormal osteoblast morphology 0.025657664602124 0.104286667806836 1.00372256529527 0.583333333333333 18.1 18 1 abnormal esophagus morphology 0.107102705034261 0.288331145857928 1.00372256529527 0.583333333333333 18.1 18 1 amyloidosis 0.107102705034261 0.288331145857928 1.00372256529527 0.583333333333333 18.1 18 1 abnormal superior cervical ganglion morphology 0.107102705034261 0.288331145857928 1.00372256529527 0.583333333333333 18.1 18 1 abnormal glossopharyngeal nerve morphology 0.107102705034261 0.288331145857928 1.00372256529527 0.583333333333333 18.1 18 1 abnormal mating frequency 0.107102705034261 0.288331145857928 1.00372256529527 0.583333333333333 18.1 18 1 interstitial pneumonia 0.107102705034261 0.288331145857928 1.00372256529527 0.583333333333333 18.1 18 1 increased litter size 0.107102705034261 0.288331145857928 1.00372256529527 0.583333333333333 18.1 18 1 abnormal corticospinal tract morphology 0.107102705034261 0.288331145857928 1.00372256529527 0.583333333333333 18.1 18 1 decreased synaptic depression 0.107102705034261 0.288331145857928 1.00372256529527 0.583333333333333 18.1 18 1 small thyroid gland 0.107102705034261 0.288331145857928 1.00372256529527 0.583333333333333 18.1 18 1 abnormal alisphenoid bone morphology 0.107102705034261 0.288331145857928 1.00372256529527 0.583333333333333 18.1 18 1 decreased circulating ketone body level 0.107102705034261 0.288331145857928 1.00372256529527 0.583333333333333 18.1 18 1 delayed somite formation 0.107102705034261 0.288331145857928 1.00372256529527 0.583333333333333 18.1 18 1 bowed ulna 0.107102705034261 0.288331145857928 1.00372256529527 0.583333333333333 18.1 18 1 abnormal B cell proliferation 0.107102705034261 0.288331145857928 1.00372256529527 0.583333333333333 18.1 18 1 abnormal palatine bone morphology 0.107102705034261 0.288331145857928 1.00372256529527 0.583333333333333 18.1 18 1 abnormal thymus corticomedullary boundary morphology 0.107102705034261 0.288331145857928 1.00372256529527 0.583333333333333 18.1 18 1 abnormal vitelline vein connection 0.107102705034261 0.288331145857928 1.00372256529527 0.583333333333333 18.1 18 1 insulin resistance 3.71364441008754e-07 8.6738877653453e-06 1.00372256529527 0.583333333333333 18.1 18 1 liver inflammation 1.23427025329941e-06 2.46606205227492e-05 1.00372256529527 0.583333333333333 18.1 18 1 abnormal long bone epiphyseal plate morphology 0.000544370526314847 0.00480184994400064 1.00372256529527 0.583333333333333 18.1 18 1 abnormal uterus morphology 0.00682988913364434 0.0370138327231815 1.00372256529527 0.583333333333333 18.1 18 1 short radius 0.00682988913364434 0.0370138327231815 1.00372256529527 0.583333333333333 18.1 18 1 abnormal skeleton morphology 2.19687002564988e-06 4.15567618920461e-05 1.00247570496571 0.582608695652174 18.1 18 1 increased thermal nociceptive threshold 2.46753510048338e-05 0.000349123922994686 1.00214686268099 0.582417582417582 18.1 18 1 decreased compact bone thickness 0.000285236748863202 0.0027879230365313 1.00158243189378 0.582089552238806 18.1 18 1 abnormal male reproductive system morphology 0.00348687556399193 0.0219030377914897 1.00038793883249 0.581395348837209 18.1 18 1 small seminiferous tubules 0.000150012550623073 0.00160152883980641 0.999847188595284 0.581081081081081 18.1 18 1 abnormal cranial ganglia morphology 0.0127204175110172 0.0603855697684263 0.99909711568561 0.580645161290323 18.1 18 1 testicular atrophy 0.00179696211386506 0.0126269583566083 0.997987007779293 0.58 18.1 18 1 decreased respiratory quotient 0.00179696211386506 0.0126269583566083 0.997987007779293 0.58 18.1 18 1 hyperactivity 6.67081284572025e-17 7.71797532731587e-15 0.997152182696105 0.579514824797844 18.1 18 1 abnormal cardiovascular system physiology 5.65291956681438e-07 1.21745778549357e-05 0.996175779090038 0.578947368421053 18.1 18 1 abnormal triglyceride level 0.0494153574514288 0.159665245349576 0.996175779090038 0.578947368421053 18.1 18 1 enlarged adrenal glands 0.0494153574514288 0.159665245349576 0.996175779090038 0.578947368421053 18.1 18 1 flaky skin 0.0494153574514288 0.159665245349576 0.996175779090038 0.578947368421053 18.1 18 1 thin dermal layer 0.0494153574514288 0.159665245349576 0.996175779090038 0.578947368421053 18.1 18 1 abnormal long term depression 0.0494153574514288 0.159665245349576 0.996175779090038 0.578947368421053 18.1 18 1 delayed sexual maturation 0.0494153574514288 0.159665245349576 0.996175779090038 0.578947368421053 18.1 18 1 abnormal nasal septum morphology 0.0494153574514288 0.159665245349576 0.996175779090038 0.578947368421053 18.1 18 1 abnormal neural crest cell migration 0.0494153574514288 0.159665245349576 0.996175779090038 0.578947368421053 18.1 18 1 abnormal optic vesicle formation 0.0494153574514288 0.159665245349576 0.996175779090038 0.578947368421053 18.1 18 1 abnormal cochlear inner hair cell morphology 0.0494153574514288 0.159665245349576 0.996175779090038 0.578947368421053 18.1 18 1 absent amnion 0.0494153574514288 0.159665245349576 0.996175779090038 0.578947368421053 18.1 18 1 eyelids fail to open 0.0494153574514288 0.159665245349576 0.996175779090038 0.578947368421053 18.1 18 1 decreased fertilization frequency 0.0494153574514288 0.159665245349576 0.996175779090038 0.578947368421053 18.1 18 1 decreased susceptibility to weight gain 0.0494153574514288 0.159665245349576 0.996175779090038 0.578947368421053 18.1 18 1 thin interventricular septum 0.0494153574514288 0.159665245349576 0.996175779090038 0.578947368421053 18.1 18 1 abnormal blood homeostasis 3.52267571273771e-06 6.46690467559782e-05 0.996175779090038 0.578947368421053 18.1 18 1 abnormal bone mineralization 1.87874970421008e-06 3.59491529940199e-05 0.995427337482908 0.578512396694215 18.1 18 1 postnatal lethality 2.62656510883475e-08 8.16697588528305e-07 0.995084677470005 0.578313253012048 18.1 18 1 abnormal osteoclast physiology 0.000486755391513678 0.00430891116153123 0.994760756676558 0.578125 18.1 18 1 abnormal metabolism 0.00328303739296072 0.0206748240885818 0.994163302768644 0.577777777777778 18.1 18 1 cardiomyopathy 0.00328303739296072 0.0206748240885818 0.994163302768644 0.577777777777778 18.1 18 1 decreased cardiac muscle contractility 1.11562646537427e-05 0.000176874686653296 0.992692646995318 0.576923076923077 18.1 18 1 absent corpus luteum 0.00169351736950386 0.0120360698761167 0.992692646995318 0.576923076923077 18.1 18 1 abnormal ocular fundus morphology 0.0239387031880772 0.0978595302881547 0.992692646995318 0.576923076923077 18.1 18 1 abnormal tectorial membrane morphology 0.0239387031880772 0.0978595302881547 0.992692646995318 0.576923076923077 18.1 18 1 abnormal heart ventricle morphology 0.000134249381188942 0.00147763422879422 0.992692646995318 0.576923076923077 18.1 18 1 neonatal lethality, complete penetrance 5.82969207881853e-20 1.11548915738931e-17 0.992402385987424 0.576754385964912 18.1 18 1 abnormal thoracic vertebrae morphology 0.000879599186668439 0.00708091578264641 0.991570960388543 0.576271186440678 18.1 18 1 abnormal aorta morphology 0.0119101483613766 0.0567557357259084 0.990687207304418 0.575757575757576 18.1 18 1 absent vibrissae 0.0119101483613766 0.0567557357259084 0.990687207304418 0.575757575757576 18.1 18 1 abnormal pulmonary alveolus morphology 1.87801976889248e-05 0.000275609095877288 0.988105948296329 0.574257425742574 18.1 18 1 decreased circulating alanine transaminase level 0.000432907732372364 0.00400318953262548 0.986853278483581 0.573529411764706 18.1 18 1 kyphosis 2.30320642255011e-07 5.64455761191467e-06 0.986515892747347 0.573333333333333 18.1 18 1 abnormal response/metabolism to endogenous compounds 0.000119615778448487 0.00135864953831329 0.986236109453885 0.573170731707317 18.1 18 1 decreased litter size 1.80243701719888e-12 1.15328646280884e-10 0.985862733172574 0.572953736654804 18.1 18 1 abnormal urine homeostasis 3.34354944987213e-05 0.00044957185170578 0.98579894805785 0.572916666666667 18.1 18 1 decreased startle reflex 5.01516582776232e-06 8.6036034459026e-05 0.985339368128685 0.572649572649573 18.1 18 1 increased leukocyte cell number 4.07016015380885e-07 9.41816128613909e-06 0.98493366998432 0.572413793103448 18.1 18 1 weight loss 3.16264066212266e-08 9.65284496568114e-07 0.983238431309648 0.571428571428571 18.1 18 1 abnormal lung morphology 4.73486341968632e-06 8.15084619824893e-05 0.983238431309648 0.571428571428571 18.1 18 1 small ears 0.0457044673609788 0.156359969147057 0.983238431309648 0.571428571428571 18.1 18 1 abnormal anxiety-related response 0.0457044673609788 0.156359969147057 0.983238431309648 0.571428571428571 18.1 18 1 trunk curl 0.0457044673609788 0.156359969147057 0.983238431309648 0.571428571428571 18.1 18 1 increased keratinocyte proliferation 0.0457044673609788 0.156359969147057 0.983238431309648 0.571428571428571 18.1 18 1 complete atrioventricular septal defect 0.0457044673609788 0.156359969147057 0.983238431309648 0.571428571428571 18.1 18 1 increased bone ossification 0.0457044673609788 0.156359969147057 0.983238431309648 0.571428571428571 18.1 18 1 increased muscle cell glucose uptake 0.0457044673609788 0.156359969147057 0.983238431309648 0.571428571428571 18.1 18 1 thick epidermis 0.000407562109751882 0.00381131860153311 0.983238431309648 0.571428571428571 18.1 18 1 increased circulating aspartate transaminase level 0.000779312687019079 0.00660490735591128 0.983238431309648 0.571428571428571 18.1 18 1 reduced long term potentiation 8.89505823709615e-06 0.000143213316276872 0.983238431309648 0.571428571428571 18.1 18 1 abnormal neuron differentiation 8.89505823709615e-06 0.000143213316276872 0.983238431309648 0.571428571428571 18.1 18 1 abnormal retinal inner nuclear layer morphology 0.022284940155578 0.091494018185124 0.983238431309648 0.571428571428571 18.1 18 1 abnormal hormone level 0.022284940155578 0.091494018185124 0.983238431309648 0.571428571428571 18.1 18 1 increased bone resorption 0.022284940155578 0.091494018185124 0.983238431309648 0.571428571428571 18.1 18 1 hypoxia 0.022284940155578 0.091494018185124 0.983238431309648 0.571428571428571 18.1 18 1 abnormal kidney medulla morphology 0.0977437604693603 0.267331065604765 0.983238431309648 0.571428571428571 18.1 18 1 decreased vascular permeability 0.0977437604693603 0.267331065604765 0.983238431309648 0.571428571428571 18.1 18 1 absent olfactory bulb 0.0977437604693603 0.267331065604765 0.983238431309648 0.571428571428571 18.1 18 1 abnormal uterus development 0.0977437604693603 0.267331065604765 0.983238431309648 0.571428571428571 18.1 18 1 abnormal sagittal suture morphology 0.0977437604693603 0.267331065604765 0.983238431309648 0.571428571428571 18.1 18 1 enlarged stomach 0.0977437604693603 0.267331065604765 0.983238431309648 0.571428571428571 18.1 18 1 abnormal maternal decidual layer morphology 0.0977437604693603 0.267331065604765 0.983238431309648 0.571428571428571 18.1 18 1 decreased CNS synapse formation 0.0977437604693603 0.267331065604765 0.983238431309648 0.571428571428571 18.1 18 1 increased circulating growth hormone level 0.0977437604693603 0.267331065604765 0.983238431309648 0.571428571428571 18.1 18 1 decreased tongue size 0.0977437604693603 0.267331065604765 0.983238431309648 0.571428571428571 18.1 18 1 increased lung compliance 0.0977437604693603 0.267331065604765 0.983238431309648 0.571428571428571 18.1 18 1 decreased compact bone area 0.0977437604693603 0.267331065604765 0.983238431309648 0.571428571428571 18.1 18 1 decreased heart rate 2.97307888051362e-05 0.000408593022943516 0.980780335231374 0.57 18.1 18 1 cochlear ganglion degeneration 0.00140566298152554 0.0104688223549245 0.979000334622968 0.568965517241379 18.1 18 1 no abnormal phenotype detected 1.71986391365539e-68 2.85210765681185e-65 0.978846444080455 0.568876080691643 18.1 18 1 abnormal gluconeogenesis 0.00271435130320718 0.0179341840885923 0.978418635077738 0.568627450980392 18.1 18 1 embryonic lethality, incomplete penetrance 0.00528188233084941 0.0298267475550236 0.97765184931357 0.568181818181818 18.1 18 1 female infertility 2.2709442511858e-11 1.20190932443078e-09 0.976769757419453 0.567669172932331 18.1 18 1 abnormal long bone metaphysis morphology 0.0103840050633107 0.051098343412434 0.976594928395394 0.567567567567568 18.1 18 1 abnormal myocardial fiber morphology 4.97116652392458e-05 0.000629301614669842 0.975636072304676 0.56701030927835 18.1 18 1 abnormal incisor morphology 0.00131797512713082 0.00990472244331698 0.975044777715401 0.566666666666667 18.1 18 1 abnormal CNS synaptic transmission 4.67390778997461e-05 0.0005931808993654 0.973306729983288 0.565656565656566 18.1 18 1 abnormal cell death 0.00493496511857083 0.0287151479121519 0.972551057056282 0.565217391304348 18.1 18 1 abnormal pulmonary artery morphology 0.0422004876582165 0.145292336401126 0.972551057056282 0.565217391304348 18.1 18 1 abnormal carpal bone morphology 0.0422004876582165 0.145292336401126 0.972551057056282 0.565217391304348 18.1 18 1 abnormal circulating insulin level 0.0422004876582165 0.145292336401126 0.972551057056282 0.565217391304348 18.1 18 1 failure of embryo implantation 0.0422004876582165 0.145292336401126 0.972551057056282 0.565217391304348 18.1 18 1 abnormal nasal cavity morphology 0.0422004876582165 0.145292336401126 0.972551057056282 0.565217391304348 18.1 18 1 abnormal cochlear ganglion morphology 0.0422004876582165 0.145292336401126 0.972551057056282 0.565217391304348 18.1 18 1 abnormal cardiovascular development 0.0422004876582165 0.145292336401126 0.972551057056282 0.565217391304348 18.1 18 1 abnormal vertebral artery topology 0.0422004876582165 0.145292336401126 0.972551057056282 0.565217391304348 18.1 18 1 hydroencephaly 1.23965465862747e-05 0.000192127162824662 0.972551057056282 0.565217391304348 18.1 18 1 cardiac fibrosis 0.000167103980587116 0.00175759472182009 0.971670920353064 0.564705882352941 18.1 18 1 increased eosinophil cell number 0.00123457510495645 0.00946380762274012 0.971344418027676 0.564516129032258 18.1 18 1 abnormal circulating hormone level 0.00967538472484526 0.0477056878157633 0.970632810395422 0.564102564102564 18.1 18 1 increased sensitivity to xenobiotic induced morbidity/mortality 2.19055769421232e-05 0.000315884768948008 0.969830634519062 0.563636363636364 18.1 18 1 abnormal platelet physiology 0.00237659353181295 0.0161523945638927 0.969830634519062 0.563636363636364 18.1 18 1 retinal degeneration 7.77842906171644e-05 0.000934726680725586 0.967875330820435 0.5625 18.1 18 1 abnormal osteoclast morphology 0.00460590367769573 0.0277078244214465 0.967875330820435 0.5625 18.1 18 1 decreased circulating LDL cholesterol level 0.0011554577812403 0.00901003520638009 0.967875330820435 0.5625 18.1 18 1 absent mandible 0.0891402257520554 0.246922395944586 0.967875330820435 0.5625 18.1 18 1 reduced male mating frequency 0.0891402257520554 0.246922395944586 0.967875330820435 0.5625 18.1 18 1 abnormal intestinal absorption 0.0891402257520554 0.246922395944586 0.967875330820435 0.5625 18.1 18 1 abnormal meiosis 0.0891402257520554 0.246922395944586 0.967875330820435 0.5625 18.1 18 1 abnormal olfaction 0.0891402257520554 0.246922395944586 0.967875330820435 0.5625 18.1 18 1 bowed tibia 0.0891402257520554 0.246922395944586 0.967875330820435 0.5625 18.1 18 1 bowed radius 0.0891402257520554 0.246922395944586 0.967875330820435 0.5625 18.1 18 1 small epididymis 0.0891402257520554 0.246922395944586 0.967875330820435 0.5625 18.1 18 1 abnormal amnion morphology 0.0891402257520554 0.246922395944586 0.967875330820435 0.5625 18.1 18 1 dystonia 0.0891402257520554 0.246922395944586 0.967875330820435 0.5625 18.1 18 1 loose skin 0.0891402257520554 0.246922395944586 0.967875330820435 0.5625 18.1 18 1 abnormal thoracic cage shape 0.0891402257520554 0.246922395944586 0.967875330820435 0.5625 18.1 18 1 embryonic lethality between somite formation and embryo turning, incomplete penetrance 0.0891402257520554 0.246922395944586 0.967875330820435 0.5625 18.1 18 1 seizures 1.93094949433511e-05 0.000282543345126975 0.965988634269128 0.56140350877193 18.1 18 1 cardiac hypertrophy 7.29534539813367e-05 0.0008844492306381 0.965680602179119 0.561224489795918 18.1 18 1 decreased anxiety-related response 9.65351712088248e-06 0.000154923379601259 0.965252362444228 0.560975609756098 18.1 18 1 abnormal excitatory postsynaptic potential 0.000278588166640017 0.00272829946660253 0.965252362444228 0.560975609756098 18.1 18 1 impaired swimming 0.00108057189569998 0.00845258676274749 0.964616491322723 0.560606060606061 18.1 18 1 abnormal skin morphology 0.00108057189569998 0.00845258676274749 0.964616491322723 0.560606060606061 18.1 18 1 enlarged liver 6.8385991292886e-05 0.000837445069959261 0.963573662683455 0.56 18.1 18 1 increased body length 0.00429480323594329 0.0263460494436718 0.963573662683455 0.56 18.1 18 1 kidney inflammation 0.00429480323594329 0.0263460494436718 0.963573662683455 0.56 18.1 18 1 increased circulating chloride level 0.00429480323594329 0.0263460494436718 0.963573662683455 0.56 18.1 18 1 abnormal axon extension 0.00429480323594329 0.0263460494436718 0.963573662683455 0.56 18.1 18 1 abnormal primitive streak morphology 0.0389196053253219 0.135213014311087 0.963573662683455 0.56 18.1 18 1 increased pre-B cell number 0.0389196053253219 0.135213014311087 0.963573662683455 0.56 18.1 18 1 abnormal feces composition 0.0389196053253219 0.135213014311087 0.963573662683455 0.56 18.1 18 1 increased cellular sensitivity to ionizing radiation 0.0389196053253219 0.135213014311087 0.963573662683455 0.56 18.1 18 1 decreased placenta weight 0.0389196053253219 0.135213014311087 0.963573662683455 0.56 18.1 18 1 abnormal renal glomerulus morphology 3.40430374789764e-05 0.000456507038970101 0.962942225158761 0.559633027522936 18.1 18 1 decreased exploration in new environment 0.000260828780476637 0.00261546834313956 0.96275429732403 0.55952380952381 18.1 18 1 syndactyly 0.00207335933653648 0.0142275347576124 0.96240710861241 0.559322033898305 18.1 18 1 short maxilla 0.0178180515294527 0.0757076906623105 0.961549348266053 0.558823529411765 18.1 18 1 thin skin 0.0178180515294527 0.0757076906623105 0.961549348266053 0.558823529411765 18.1 18 1 abnormal skin physiology 0.0178180515294527 0.0757076906623105 0.961549348266053 0.558823529411765 18.1 18 1 increased circulating triglyceride level 2.13515909891708e-06 4.05435744927957e-05 0.961200328538914 0.558620689655172 18.1 18 1 decreased IgG level 3.19039577224188e-05 0.00043366718488807 0.961093421595467 0.558558558558559 18.1 18 1 abnormal spatial learning 5.39424551380449e-07 1.16679875787728e-05 0.960617915251911 0.558282208588957 18.1 18 1 abnormal blood circulation 0.00837370756623361 0.044037204167032 0.960372421279191 0.558139534883721 18.1 18 1 abnormal hair growth 0.00400148974135487 0.0247297036810441 0.959602892095474 0.557692307692308 18.1 18 1 abnormal brain wave pattern 0.00400148974135487 0.0247297036810441 0.959602892095474 0.557692307692308 18.1 18 1 abnormal female meiosis 0.00400148974135487 0.0247297036810441 0.959602892095474 0.557692307692308 18.1 18 1 increased percent body fat/body weight 0.00400148974135487 0.0247297036810441 0.959602892095474 0.557692307692308 18.1 18 1 increased bone mineral density 2.98862349566552e-05 0.00040959784823515 0.959310062406095 0.557522123893805 18.1 18 1 abnormal long bone morphology 0.00193442511191759 0.0134786623694538 0.959060437097116 0.557377049180328 18.1 18 1 abnormal action potential 0.000943120863458859 0.00751927290978818 0.958657470526907 0.557142857142857 18.1 18 1 abnormal hair follicle morphology 0.00180365312737815 0.0126560991660174 0.955926252662158 0.555555555555556 18.1 18 1 decreased osteoclast cell number 0.00778043850321024 0.0418009520015885 0.955926252662158 0.555555555555556 18.1 18 1 abnormal cochlea morphology 0.00372558499009319 0.0233729953665998 0.955926252662158 0.555555555555556 18.1 18 1 heart right ventricle hypertrophy 0.0165047128644287 0.0745108407445853 0.955926252662158 0.555555555555556 18.1 18 1 abnormal trigeminal nerve morphology 0.0358648383069238 0.125388313827791 0.955926252662158 0.555555555555556 18.1 18 1 cryptorchism 0.0358648383069238 0.125388313827791 0.955926252662158 0.555555555555556 18.1 18 1 abnormal mitral valve morphology 0.0812858904449106 0.227573047250102 0.955926252662158 0.555555555555556 18.1 18 1 thick dermal layer 0.0812858904449106 0.227573047250102 0.955926252662158 0.555555555555556 18.1 18 1 blepharoptosis 0.0812858904449106 0.227573047250102 0.955926252662158 0.555555555555556 18.1 18 1 abnormal iron level 0.0812858904449106 0.227573047250102 0.955926252662158 0.555555555555556 18.1 18 1 eye inflammation 0.0812858904449106 0.227573047250102 0.955926252662158 0.555555555555556 18.1 18 1 abnormal thyroid cartilage morphology 0.0812858904449106 0.227573047250102 0.955926252662158 0.555555555555556 18.1 18 1 abnormal thymus medulla morphology 0.0812858904449106 0.227573047250102 0.955926252662158 0.555555555555556 18.1 18 1 absent parathyroid glands 0.202667095159069 0.415267215163249 0.955926252662158 0.555555555555556 18.1 18 1 abnormal cholinergic neuron morphology 0.202667095159069 0.415267215163249 0.955926252662158 0.555555555555556 18.1 18 1 absent enteric neurons 0.202667095159069 0.415267215163249 0.955926252662158 0.555555555555556 18.1 18 1 abnormal germ cell morphology 0.202667095159069 0.415267215163249 0.955926252662158 0.555555555555556 18.1 18 1 abnormal thymus lobule morphology 0.202667095159069 0.415267215163249 0.955926252662158 0.555555555555556 18.1 18 1 abnormal posterior semicircular canal morphology 0.202667095159069 0.415267215163249 0.955926252662158 0.555555555555556 18.1 18 1 abnormal NMDA-mediated synaptic currents 0.202667095159069 0.415267215163249 0.955926252662158 0.555555555555556 18.1 18 1 genetic imprinting 0.202667095159069 0.415267215163249 0.955926252662158 0.555555555555556 18.1 18 1 abnormal lens capsule morphology 0.202667095159069 0.415267215163249 0.955926252662158 0.555555555555556 18.1 18 1 abnormal artery development 0.202667095159069 0.415267215163249 0.955926252662158 0.555555555555556 18.1 18 1 priapism 0.202667095159069 0.415267215163249 0.955926252662158 0.555555555555556 18.1 18 1 abnormal thymus physiology 0.202667095159069 0.415267215163249 0.955926252662158 0.555555555555556 18.1 18 1 decreased cellular sensitivity to ionizing radiation 0.202667095159069 0.415267215163249 0.955926252662158 0.555555555555556 18.1 18 1 decreased muscle weight 0.202667095159069 0.415267215163249 0.955926252662158 0.555555555555556 18.1 18 1 short frontal bone 0.202667095159069 0.415267215163249 0.955926252662158 0.555555555555556 18.1 18 1 absent cochlear outer hair cells 0.202667095159069 0.415267215163249 0.955926252662158 0.555555555555556 18.1 18 1 abnormal hair cell mechanoelectric transduction 0.202667095159069 0.415267215163249 0.955926252662158 0.555555555555556 18.1 18 1 abnormal CNS synapse formation 0.202667095159069 0.415267215163249 0.955926252662158 0.555555555555556 18.1 18 1 hemothorax 0.202667095159069 0.415267215163249 0.955926252662158 0.555555555555556 18.1 18 1 abnormal oxygen consumption 0.202667095159069 0.415267215163249 0.955926252662158 0.555555555555556 18.1 18 1 absent adrenal gland 0.202667095159069 0.415267215163249 0.955926252662158 0.555555555555556 18.1 18 1 abnormal inguinal fat pad morphology 0.202667095159069 0.415267215163249 0.955926252662158 0.555555555555556 18.1 18 1 decreased susceptibility to atherosclerosis 0.202667095159069 0.415267215163249 0.955926252662158 0.555555555555556 18.1 18 1 abnormal leukopoiesis 0.202667095159069 0.415267215163249 0.955926252662158 0.555555555555556 18.1 18 1 decreased pulmonary ventilation 0.202667095159069 0.415267215163249 0.955926252662158 0.555555555555556 18.1 18 1 increased tidal volume 0.202667095159069 0.415267215163249 0.955926252662158 0.555555555555556 18.1 18 1 eye opacity 0.202667095159069 0.415267215163249 0.955926252662158 0.555555555555556 18.1 18 1 abnormal ventricle myocardium morphology 0.202667095159069 0.415267215163249 0.955926252662158 0.555555555555556 18.1 18 1 decreased pancreatic beta cell proliferation 0.202667095159069 0.415267215163249 0.955926252662158 0.555555555555556 18.1 18 1 adipose tissue inflammation 0.202667095159069 0.415267215163249 0.955926252662158 0.555555555555556 18.1 18 1 abnormal lipid level 0.000403677700996833 0.00378210275416053 0.953622815908755 0.55421686746988 18.1 18 1 abnormal intestine morphology 0.0008212484992808 0.00677564060351904 0.953342668195503 0.554054054054054 18.1 18 1 increased body weight 1.04781239357929e-08 3.47524443870464e-07 0.952512230331221 0.553571428571429 18.1 18 1 hepatic necrosis 0.00722443694426585 0.0391094383000246 0.951858481374233 0.553191489361702 18.1 18 1 abnormal compact bone morphology 0.0152779129863498 0.0695403633184721 0.950895061858673 0.552631578947368 18.1 18 1 decreased threshold for auditory brainstem response 0.0152779129863498 0.0695403633184721 0.950895061858673 0.552631578947368 18.1 18 1 dermatitis 0.00322380278684839 0.0203533234321964 0.949333657816212 0.551724137931034 18.1 18 1 aphagia 0.0330315529715947 0.120919890617561 0.949333657816212 0.551724137931034 18.1 18 1 absent long term depression 0.0330315529715947 0.120919890617561 0.949333657816212 0.551724137931034 18.1 18 1 decreased bone strength 0.0330315529715947 0.120919890617561 0.949333657816212 0.551724137931034 18.1 18 1 polychromatophilia 0.0330315529715947 0.120919890617561 0.949333657816212 0.551724137931034 18.1 18 1 abnormal dendritic cell physiology 8.05738017813611e-05 0.000958982449431271 0.948779140492721 0.551401869158878 18.1 18 1 increased T cell proliferation 8.05738017813611e-05 0.000958982449431271 0.948779140492721 0.551401869158878 18.1 18 1 abnormal excitatory postsynaptic currents 0.000713749335036052 0.00611170902203849 0.948572973795526 0.551282051282051 18.1 18 1 abnormal epidermis stratum corneum morphology 0.00670440684556562 0.0368592965105655 0.948122773048589 0.551020408163265 18.1 18 1 abnormal epidermal layer morphology 0.00145736361928509 0.0107892619136061 0.947613850465095 0.550724637681159 18.1 18 1 abnormal female reproductive system morphology 0.014134700712203 0.0664651569406521 0.946366990135536 0.55 18.1 18 1 perinatal lethality 0.014134700712203 0.0664651569406521 0.946366990135536 0.55 18.1 18 1 waved hair 0.0741394212268472 0.208976555582756 0.946366990135536 0.55 18.1 18 1 small gonad 0.0741394212268472 0.208976555582756 0.946366990135536 0.55 18.1 18 1 abnormal circulating enzyme level 0.0741394212268472 0.208976555582756 0.946366990135536 0.55 18.1 18 1 abnormal dopamine level 0.0741394212268472 0.208976555582756 0.946366990135536 0.55 18.1 18 1 abnormal trachea morphology 0.0741394212268472 0.208976555582756 0.946366990135536 0.55 18.1 18 1 decreased myocardial infarction size 0.0741394212268472 0.208976555582756 0.946366990135536 0.55 18.1 18 1 abnormal lens epithelium morphology 0.0741394212268472 0.208976555582756 0.946366990135536 0.55 18.1 18 1 dilated vasculature 0.0741394212268472 0.208976555582756 0.946366990135536 0.55 18.1 18 1 small ovary 0.000305552764307041 0.0029748043100343 0.945421568566969 0.549450549450549 18.1 18 1 abnormal vibrissa morphology 0.0130713953247014 0.0618157716163399 0.942270163338413 0.547619047619048 18.1 18 1 abnormal muscle morphology 0.0130713953247014 0.0618157716163399 0.942270163338413 0.547619047619048 18.1 18 1 abnormal spleen white pulp morphology 0.0130713953247014 0.0618157716163399 0.942270163338413 0.547619047619048 18.1 18 1 abnormal cytotoxic T cell physiology 0.0130713953247014 0.0618157716163399 0.942270163338413 0.547619047619048 18.1 18 1 increased B cell number 5.69598387119626e-05 0.000708437993980034 0.941219694928894 0.547008547008547 18.1 18 1 abnormal limb morphology 0.00117311363776972 0.00907593959003938 0.940631432619563 0.546666666666667 18.1 18 1 abnormal QRS complex 0.0279911656506921 0.109478026031598 0.938545775341028 0.545454545454545 18.1 18 1 diarrhea 0.0279911656506921 0.109478026031598 0.938545775341028 0.545454545454545 18.1 18 1 head tossing 0.0279911656506921 0.109478026031598 0.938545775341028 0.545454545454545 18.1 18 1 cardiovascular system phenotype 0.0279911656506921 0.109478026031598 0.938545775341028 0.545454545454545 18.1 18 1 increased circulating cholesterol level 1.11372891696022e-06 2.26957317460437e-05 0.938545775341027 0.545454545454545 18.1 18 1 teratozoospermia 0.000499337768859861 0.00441244298415241 0.938545775341027 0.545454545454545 18.1 18 1 abnormal gametogenesis 0.0120838978486947 0.0574736059247191 0.938545775341027 0.545454545454545 18.1 18 1 decreased sensitivity to induced morbidity/mortality 0.0120838978486947 0.0574736059247191 0.938545775341027 0.545454545454545 18.1 18 1 abnormal abdominal fat pad morphology 0.0676467608467492 0.193522278058019 0.938545775341027 0.545454545454545 18.1 18 1 abnormal oogenesis 0.0676467608467492 0.193522278058019 0.938545775341027 0.545454545454545 18.1 18 1 abnormal retinal layer morphology 0.0676467608467492 0.193522278058019 0.938545775341027 0.545454545454545 18.1 18 1 abnormal blood-brain barrier function 0.0676467608467492 0.193522278058019 0.938545775341027 0.545454545454545 18.1 18 1 increased circulating creatine kinase level 0.0676467608467492 0.193522278058019 0.938545775341027 0.545454545454545 18.1 18 1 abnormal thrombopoiesis 0.180004299460676 0.37563816686949 0.938545775341027 0.545454545454545 18.1 18 1 abnormal sebaceous gland morphology 0.180004299460676 0.37563816686949 0.938545775341027 0.545454545454545 18.1 18 1 social withdrawal 0.180004299460676 0.37563816686949 0.938545775341027 0.545454545454545 18.1 18 1 abnormal food preference 0.180004299460676 0.37563816686949 0.938545775341027 0.545454545454545 18.1 18 1 failure of somite differentiation 0.180004299460676 0.37563816686949 0.938545775341027 0.545454545454545 18.1 18 1 abnormal primary sex determination 0.180004299460676 0.37563816686949 0.938545775341027 0.545454545454545 18.1 18 1 abnormal larynx morphology 0.180004299460676 0.37563816686949 0.938545775341027 0.545454545454545 18.1 18 1 allodynia 0.180004299460676 0.37563816686949 0.938545775341027 0.545454545454545 18.1 18 1 abnormal frequency of paradoxical sleep 0.180004299460676 0.37563816686949 0.938545775341027 0.545454545454545 18.1 18 1 rectal hemorrhage 0.180004299460676 0.37563816686949 0.938545775341027 0.545454545454545 18.1 18 1 abnormal nerve fiber response 0.180004299460676 0.37563816686949 0.938545775341027 0.545454545454545 18.1 18 1 abnormal lymph circulation 0.180004299460676 0.37563816686949 0.938545775341027 0.545454545454545 18.1 18 1 abnormal ureter development 0.180004299460676 0.37563816686949 0.938545775341027 0.545454545454545 18.1 18 1 pathological neovascularization 0.180004299460676 0.37563816686949 0.938545775341027 0.545454545454545 18.1 18 1 abnormal coronal suture morphology 0.180004299460676 0.37563816686949 0.938545775341027 0.545454545454545 18.1 18 1 abnormal spinal cord ventral horn morphology 0.180004299460676 0.37563816686949 0.938545775341027 0.545454545454545 18.1 18 1 cyclopia 0.180004299460676 0.37563816686949 0.938545775341027 0.545454545454545 18.1 18 1 abnormal Bruch membrane morphology 0.180004299460676 0.37563816686949 0.938545775341027 0.545454545454545 18.1 18 1 increased circulating triiodothyronine level 0.180004299460676 0.37563816686949 0.938545775341027 0.545454545454545 18.1 18 1 decreased palatine bone horizontal plate size 0.180004299460676 0.37563816686949 0.938545775341027 0.545454545454545 18.1 18 1 increased number of Howell-Jolly bodies 0.180004299460676 0.37563816686949 0.938545775341027 0.545454545454545 18.1 18 1 aberrant origin of the right subclavian artery 0.180004299460676 0.37563816686949 0.938545775341027 0.545454545454545 18.1 18 1 shortened PR interval 0.180004299460676 0.37563816686949 0.938545775341027 0.545454545454545 18.1 18 1 increased pancreatic beta cell proliferation 0.180004299460676 0.37563816686949 0.938545775341027 0.545454545454545 18.1 18 1 hunched posture 0.00101349512768349 0.00799071039655369 0.936565720962671 0.544303797468354 18.1 18 1 abnormal lymphocyte physiology 0.0111679068182571 0.0549015182024004 0.935145247169502 0.543478260869565 18.1 18 1 abnormal intestinal goblet cell morphology 0.02576033740545 0.10461851313642 0.934076509744166 0.542857142857143 18.1 18 1 abnormal colon morphology 0.00458729132055141 0.0276292667309241 0.933243256836276 0.542372881355932 18.1 18 1 abnormal intestinal epithelium morphology 0.0103190671683943 0.0508290684779816 0.932028096345604 0.541666666666667 18.1 18 1 increased stereotypic behavior 0.0617510967245077 0.19207300045873 0.932028096345604 0.541666666666667 18.1 18 1 abnormal startle reflex 0.0617510967245077 0.19207300045873 0.932028096345604 0.541666666666667 18.1 18 1 abnormal primitive streak formation 0.0617510967245077 0.19207300045873 0.932028096345604 0.541666666666667 18.1 18 1 decreased ovulation rate 0.0617510967245077 0.19207300045873 0.932028096345604 0.541666666666667 18.1 18 1 increased body temperature 0.0617510967245077 0.19207300045873 0.932028096345604 0.541666666666667 18.1 18 1 abnormal heart left ventricle morphology 0.00191857301846324 0.0133869575972716 0.932028096345604 0.541666666666667 18.1 18 1 increased osteoclast cell number 0.00424846357948485 0.026190961967704 0.930852777182495 0.540983606557377 18.1 18 1 increased insulin secretion 0.0237055455716263 0.097065917052544 0.930090407995613 0.540540540540541 18.1 18 1 abnormal calcium ion homeostasis 0.0237055455716263 0.097065917052544 0.930090407995613 0.540540540540541 18.1 18 1 abnormal humerus morphology 0.0237055455716263 0.097065917052544 0.930090407995613 0.540540540540541 18.1 18 1 decreased circulating alkaline phosphatase level 0.00953307195251366 0.0474558010391489 0.929160317587617 0.54 18.1 18 1 abnormal circulating protein level 0.00953307195251366 0.0474558010391489 0.929160317587617 0.54 18.1 18 1 decreased body temperature 0.00880573059931048 0.0461628132050259 0.92651313719563 0.538461538461538 18.1 18 1 small lens 0.0218141959581049 0.0900140872512513 0.92651313719563 0.538461538461538 18.1 18 1 impaired macrophage chemotaxis 0.0218141959581049 0.0900140872512513 0.92651313719563 0.538461538461538 18.1 18 1 decreased B-1 B cell number 0.0218141959581049 0.0900140872512513 0.92651313719563 0.538461538461538 18.1 18 1 abnormal xiphoid process morphology 0.0563973244854409 0.179741633129448 0.92651313719563 0.538461538461538 18.1 18 1 abnormal erythrocyte osmotic lysis 0.0563973244854409 0.179741633129448 0.92651313719563 0.538461538461538 18.1 18 1 short premaxilla 0.160686838753087 0.340467215841826 0.92651313719563 0.538461538461538 18.1 18 1 abnormal renal/urinary system morphology 0.160686838753087 0.340467215841826 0.92651313719563 0.538461538461538 18.1 18 1 dystrophic cardiac calcinosis 0.160686838753087 0.340467215841826 0.92651313719563 0.538461538461538 18.1 18 1 abnormal otolith morphology 0.160686838753087 0.340467215841826 0.92651313719563 0.538461538461538 18.1 18 1 anal atresia 0.160686838753087 0.340467215841826 0.92651313719563 0.538461538461538 18.1 18 1 abnormal vestibulocochlear ganglion morphology 0.160686838753087 0.340467215841826 0.92651313719563 0.538461538461538 18.1 18 1 abnormal retinal inner plexiform layer morphology 0.160686838753087 0.340467215841826 0.92651313719563 0.538461538461538 18.1 18 1 small otic vesicle 0.160686838753087 0.340467215841826 0.92651313719563 0.538461538461538 18.1 18 1 decreased endocochlear potential 0.160686838753087 0.340467215841826 0.92651313719563 0.538461538461538 18.1 18 1 abnormal exocrine pancreas morphology 0.160686838753087 0.340467215841826 0.92651313719563 0.538461538461538 18.1 18 1 abnormal vertebral arch development 0.160686838753087 0.340467215841826 0.92651313719563 0.538461538461538 18.1 18 1 impaired righting response 0.000559677025276725 0.00492812955885258 0.923726631519853 0.536842105263158 18.1 18 1 arrested B cell differentiation 0.0200741198338494 0.0831546595948382 0.923284868424913 0.536585365853659 18.1 18 1 short humerus 0.0200741198338494 0.0831546595948382 0.923284868424913 0.536585365853659 18.1 18 1 arrest of spermatogenesis 0.00121864153441489 0.00935608276807726 0.921786029352795 0.535714285714286 18.1 18 1 abnormal seminal vesicle morphology 0.00751107873615294 0.0405288684515844 0.921786029352795 0.535714285714286 18.1 18 1 reddish skin 0.0515339515584767 0.165514143966056 0.921786029352795 0.535714285714286 18.1 18 1 abnormal respiration 0.0515339515584767 0.165514143966056 0.921786029352795 0.535714285714286 18.1 18 1 atelectasis 0.00288772927706158 0.0184421734959966 0.92092050256467 0.535211267605634 18.1 18 1 increased circulating free fatty acid level 0.00288772927706158 0.0184421734959966 0.92092050256467 0.535211267605634 18.1 18 1 abnormal suckling behavior 0.00104645801686307 0.00822453180709919 0.918992738354756 0.534090909090909 18.1 18 1 increased circulating HDL cholesterol level 0.000384352660245942 0.00361465876129218 0.917689202555672 0.533333333333333 18.1 18 1 abnormal ovarian follicle morphology 0.0170021371006769 0.0757076906623105 0.917689202555671 0.533333333333333 18.1 18 1 epidermal hyperplasia 0.00640521659708122 0.0361291979257132 0.917689202555671 0.533333333333333 18.1 18 1 gastrointestinal hemorrhage 0.0471137759881161 0.159665245349576 0.917689202555671 0.533333333333333 18.1 18 1 increased metastatic potential 0.0471137759881161 0.159665245349576 0.917689202555671 0.533333333333333 18.1 18 1 abnormal spleen marginal zone morphology 0.0471137759881161 0.159665245349576 0.917689202555671 0.533333333333333 18.1 18 1 hyperpigmentation 0.144007201434963 0.307879599114286 0.917689202555671 0.533333333333333 18.1 18 1 abnormal epidermis stratum spinosum morphology 0.144007201434963 0.307879599114286 0.917689202555671 0.533333333333333 18.1 18 1 no suckling reflex 0.144007201434963 0.307879599114286 0.917689202555671 0.533333333333333 18.1 18 1 abnormal cricoid cartilage morphology 0.144007201434963 0.307879599114286 0.917689202555671 0.533333333333333 18.1 18 1 abnormal olfactory nerve morphology 0.144007201434963 0.307879599114286 0.917689202555671 0.533333333333333 18.1 18 1 abnormal secondary palate development 0.144007201434963 0.307879599114286 0.917689202555671 0.533333333333333 18.1 18 1 herniated liver 0.144007201434963 0.307879599114286 0.917689202555671 0.533333333333333 18.1 18 1 abnormal long term potentiation 0.0430939754519475 0.148265925223678 0.914104479108188 0.53125 18.1 18 1 increased circulating insulin level 1.72191189728658e-05 0.000254955705029784 0.914104479108188 0.53125 18.1 18 1 increased circulating LDL cholesterol level 0.0144052049246352 0.0675456121583979 0.91300711478753 0.530612244897959 18.1 18 1 abnormal response to novel object 0.013261592263821 0.0625665969330361 0.910941487830997 0.529411764705882 18.1 18 1 impaired synaptic plasticity 0.0394359190370865 0.13691116343999 0.910941487830997 0.529411764705882 18.1 18 1 enlarged sebaceous gland 0.129466837996052 0.307879599114286 0.910941487830997 0.529411764705882 18.1 18 1 increased incidence of corneal inflammation 0.129466837996052 0.307879599114286 0.910941487830997 0.529411764705882 18.1 18 1 abnormal glutamate-mediated receptor currents 0.129466837996052 0.307879599114286 0.910941487830997 0.529411764705882 18.1 18 1 decreased vasoconstriction 0.129466837996052 0.307879599114286 0.910941487830997 0.529411764705882 18.1 18 1 abnormal testis development 0.129466837996052 0.307879599114286 0.910941487830997 0.529411764705882 18.1 18 1 increased regulatory T cell number 0.129466837996052 0.307879599114286 0.910941487830997 0.529411764705882 18.1 18 1 abnormal survival 0.129466837996052 0.307879599114286 0.910941487830997 0.529411764705882 18.1 18 1 decreased T cell number 2.33940826893885e-05 0.000336374454854647 0.908426811536088 0.527950310559006 18.1 18 1 abnormal inflammatory response 0.00397090391902441 0.0246632297092965 0.90812994002905 0.527777777777778 18.1 18 1 head tilt 0.0361048589512973 0.126138815507517 0.90812994002905 0.527777777777778 18.1 18 1 abnormal learning/memory/conditioning 0.0112434179590574 0.0552181681602275 0.907260916162993 0.527272727272727 18.1 18 1 decreased T cell proliferation 5.36078622772364e-05 0.000675187632479116 0.906838147795723 0.527027027027027 18.1 18 1 abnormal nail morphology 0.116697593771002 0.307879599114286 0.905614344627307 0.526315789473684 18.1 18 1 abnormal neurotransmitter level 0.116697593771002 0.307879599114286 0.905614344627307 0.526315789473684 18.1 18 1 maternal imprinting 0.116697593771002 0.307879599114286 0.905614344627307 0.526315789473684 18.1 18 1 increased circulating VLDL cholesterol level 0.116697593771002 0.307879599114286 0.905614344627307 0.526315789473684 18.1 18 1 increased neutrophil cell number 8.41405856415881e-05 0.000982627731377702 0.901866974925401 0.524137931034483 18.1 18 1 abnormal salivary gland morphology 0.105417870479302 0.286768008819449 0.901301895367177 0.523809523809524 18.1 18 1 abnormal associative learning 0.105417870479302 0.286768008819449 0.901301895367177 0.523809523809524 18.1 18 1 abnormal erythrocyte physiology 0.105417870479302 0.286768008819449 0.901301895367177 0.523809523809524 18.1 18 1 dry skin 0.105417870479302 0.286768008819449 0.901301895367177 0.523809523809524 18.1 18 1 abnormal stapes morphology 0.105417870479302 0.286768008819449 0.901301895367177 0.523809523809524 18.1 18 1 abnormal clavicle morphology 0.105417870479302 0.286768008819449 0.901301895367177 0.523809523809524 18.1 18 1 abnormal bile salt homeostasis 0.105417870479302 0.286768008819449 0.901301895367177 0.523809523809524 18.1 18 1 increased liver weight 0.00210182297081717 0.0144029879887265 0.899439701368485 0.522727272727273 18.1 18 1 lethality, incomplete penetrance 0.0254721306831122 0.104042569908443 0.899439701368485 0.522727272727273 18.1 18 1 abnormal blood vessel physiology 0.0954063315978758 0.263107815797911 0.897739437282722 0.521739130434783 18.1 18 1 blistering 0.0954063315978758 0.263107815797911 0.897739437282722 0.521739130434783 18.1 18 1 bidirectional circling 0.0954063315978758 0.263107815797911 0.897739437282722 0.521739130434783 18.1 18 1 pancreas inflammation 0.0954063315978758 0.263107815797911 0.897739437282722 0.521739130434783 18.1 18 1 decreased neutrophil cell number 0.000481476608573742 0.0042697791936798 0.897100021729102 0.521367521367521 18.1 18 1 short mandible 0.0152522267540288 0.0695403633184721 0.891059828374368 0.517857142857143 18.1 18 1 abnormal circulating glucose level 0.0713579500444219 0.202282507960683 0.890000304202699 0.517241379310345 18.1 18 1 focal hair loss 0.0713579500444219 0.202282507960683 0.890000304202699 0.517241379310345 18.1 18 1 absent mature ovarian follicles 0.0649303183671351 0.192164386601129 0.888086325053876 0.516129032258065 18.1 18 1 abnormal retinal photoreceptor layer morphology 0.0649303183671351 0.192164386601129 0.888086325053876 0.516129032258065 18.1 18 1 abnormal CD8-positive, alpha beta T cell morphology 0.0649303183671351 0.192164386601129 0.888086325053876 0.516129032258065 18.1 18 1 abnormal intestine physiology 0.0649303183671351 0.192164386601129 0.888086325053876 0.516129032258065 18.1 18 1 decreased IgM level 0.00204216446474326 0.0140328290222344 0.886941883913342 0.515463917525773 18.1 18 1 decreased systemic arterial blood pressure 0.0591407108657812 0.187285191952426 0.886404343377637 0.515151515151515 18.1 18 1 dilated heart atrium 0.0591407108657812 0.187285191952426 0.886404343377637 0.515151515151515 18.1 18 1 abnormal T cell differentiation 0.00173987310692764 0.0123478868858274 0.885888091576019 0.514851485148515 18.1 18 1 lung inflammation 0.000316744050930422 0.00307773760425556 0.88563755761347 0.514705882352941 18.1 18 1 increased white adipose tissue amount 0.0491930230742832 0.159665245349576 0.883585887595832 0.513513513513513 18.1 18 1 decreased circulating chloride level 0.0491930230742832 0.159665245349576 0.883585887595832 0.513513513513513 18.1 18 1 skin inflammation 0.0491930230742832 0.159665245349576 0.883585887595832 0.513513513513513 18.1 18 1 increased spleen weight 0.00107794182770154 0.00845258676274749 0.883174343167516 0.513274336283186 18.1 18 1 abnormal trabecular bone morphology 0.000849261959032153 0.00692390385462497 0.882022710439537 0.512605042016807 18.1 18 1 scaly skin 0.0410413953799457 0.142286370742321 0.881317374405599 0.51219512195122 18.1 18 1 short ulna 0.0410413953799457 0.142286370742321 0.881317374405599 0.51219512195122 18.1 18 1 abnormal intestinal mucosa morphology 0.0375235154621693 0.130911282906236 0.880341386172592 0.511627906976744 18.1 18 1 abnormal autopod morphology 0.0343271239738398 0.120919890617561 0.879452152449185 0.511111111111111 18.1 18 1 abnormal innervation 0.0314199304273422 0.119391440160807 0.8786385981916 0.51063829787234 18.1 18 1 abnormal thrombosis 0.0263619759602708 0.106974576184623 0.877202914207627 0.509803921568627 18.1 18 1 abnormal T-helper 2 physiology 0.0221568770923172 0.0913259847011416 0.875976056984959 0.509090909090909 18.1 18 1 decreased susceptibility to induced arthritis 0.0203249062661728 0.0841234681149832 0.875427199806397 0.508771929824561 18.1 18 1 abnormal male meiosis 0.0171209633219073 0.0757076906623105 0.874437457353253 0.508196721311475 18.1 18 1 skin lesions 0.0157213736402618 0.0714934495980828 0.873989716719687 0.507936507936508 18.1 18 1 internal hemorrhage 0.0132678914099202 0.0625665969330361 0.873174427804837 0.507462686567164 18.1 18 1 maternal effect 0.0132678914099202 0.0625665969330361 0.873174427804837 0.507462686567164 18.1 18 1 increased lymphocyte cell number 0.0121937583736416 0.0579407334373132 0.872802230691535 0.507246376811594 18.1 18 1 abnormal cytokine secretion 0.000289072384840352 0.00281987277368775 0.871506791388097 0.506493506493506 18.1 18 1 abnormal leukocyte migration 0.0346500290590489 0.121397108851245 0.860333627395942 0.5 18.1 18 1 abnormal cardiovascular system morphology 0.0413971997751343 0.143419964402015 0.860333627395942 0.5 18.1 18 1 abnormal retinal outer nuclear layer morphology 0.065316464371077 0.193077486777248 0.860333627395942 0.5 18.1 18 1 abnormal vision 0.0788455026944764 0.221613771697751 0.860333627395942 0.5 18.1 18 1 decreased pancreatic beta cell number 0.0788455026944764 0.221613771697751 0.860333627395942 0.5 18.1 18 1 increased width of hypertrophic chondrocyte zone 0.0788455026944764 0.221613771697751 0.860333627395942 0.5 18.1 18 1 abnormal crypts of Lieberkuhn morphology 0.0867666612823222 0.242099910196048 0.860333627395942 0.5 18.1 18 1 increased dopamine level 0.0867666612823222 0.242099910196048 0.860333627395942 0.5 18.1 18 1 abnormal lumbar vertebrae morphology 0.0867666612823222 0.242099910196048 0.860333627395942 0.5 18.1 18 1 abnormal serotonin level 0.0867666612823222 0.242099910196048 0.860333627395942 0.5 18.1 18 1 increased susceptibility to otitis media 0.116573100328477 0.307879599114286 0.860333627395942 0.5 18.1 18 1 apnea 0.129061566471244 0.307879599114286 0.860333627395942 0.5 18.1 18 1 abnormal retinal ganglion layer morphology 0.129061566471244 0.307879599114286 0.860333627395942 0.5 18.1 18 1 abnormal mouth morphology 0.198874177117871 0.41259342417073 0.860333627395942 0.5 18.1 18 1 abnormal epicardium morphology 0.198874177117871 0.41259342417073 0.860333627395942 0.5 18.1 18 1 paternal imprinting 0.198874177117871 0.41259342417073 0.860333627395942 0.5 18.1 18 1 abnormal pulmonary elastic fiber morphology 0.198874177117871 0.41259342417073 0.860333627395942 0.5 18.1 18 1 abnormal molar crown morphology 0.198874177117871 0.41259342417073 0.860333627395942 0.5 18.1 18 1 decreased circulating growth hormone level 0.198874177117871 0.41259342417073 0.860333627395942 0.5 18.1 18 1 abnormal Langerhans cell physiology 0.198874177117871 0.41259342417073 0.860333627395942 0.5 18.1 18 1 abnormal enteric nervous system morphology 0.252905893887091 0.499288421463603 0.860333627395942 0.5 18.1 18 1 abnormal pilomotor reflex 0.252905893887091 0.499288421463603 0.860333627395942 0.5 18.1 18 1 abnormal aorta elastic fiber morphology 0.252905893887091 0.499288421463603 0.860333627395942 0.5 18.1 18 1 stria vascularis degeneration 0.252905893887091 0.499288421463603 0.860333627395942 0.5 18.1 18 1 small parietal bone 0.252905893887091 0.499288421463603 0.860333627395942 0.5 18.1 18 1 abnormal cochlear outer hair cell physiology 0.252905893887091 0.499288421463603 0.860333627395942 0.5 18.1 18 1 abnormal anogenital distance 0.252905893887091 0.499288421463603 0.860333627395942 0.5 18.1 18 1 hemoperitoneum 0.252905893887091 0.499288421463603 0.860333627395942 0.5 18.1 18 1 decreased keratinocyte proliferation 0.252905893887091 0.499288421463603 0.860333627395942 0.5 18.1 18 1 reduced cerebellar foliation 0.252905893887091 0.499288421463603 0.860333627395942 0.5 18.1 18 1 abnormal behavioral response to addictive substance 0.252905893887091 0.499288421463603 0.860333627395942 0.5 18.1 18 1 impaired behavioral response to cocaine 0.252905893887091 0.499288421463603 0.860333627395942 0.5 18.1 18 1 decreased prostaglandin level 0.252905893887091 0.499288421463603 0.860333627395942 0.5 18.1 18 1 increased type II pneumocyte number 0.252905893887091 0.499288421463603 0.860333627395942 0.5 18.1 18 1 abnormal digestive system physiology 0.0378633401707381 0.132004286860142 0.860333627395942 0.5 18.1 18 1 abnormal epidermis stratum granulosum morphology 0.0717270343428121 0.203097322626915 0.860333627395942 0.5 18.1 18 1 abnormal reflex 0.0717270343428121 0.203097322626915 0.860333627395942 0.5 18.1 18 1 abnormal response to new environment 0.0956021241007276 0.263210053902114 0.860333627395942 0.5 18.1 18 1 abnormal pain threshold 0.0956021241007276 0.263210053902114 0.860333627395942 0.5 18.1 18 1 disorganized myocardium 0.0956021241007276 0.263210053902114 0.860333627395942 0.5 18.1 18 1 increased circulating luteinizing hormone level 0.105484513796903 0.286768008819449 0.860333627395942 0.5 18.1 18 1 enhanced coordination 0.105484513796903 0.286768008819449 0.860333627395942 0.5 18.1 18 1 decreased circulating progesterone level 0.105484513796903 0.286768008819449 0.860333627395942 0.5 18.1 18 1 abnormal Peyer's patch T cell area morphology 0.159255766315156 0.339023293717544 0.860333627395942 0.5 18.1 18 1 abnormal physiological neovascularization 0.159255766315156 0.339023293717544 0.860333627395942 0.5 18.1 18 1 abnormal incus morphology 0.159255766315156 0.339023293717544 0.860333627395942 0.5 18.1 18 1 abnormal response to tactile stimuli 0.159255766315156 0.339023293717544 0.860333627395942 0.5 18.1 18 1 abnormal stomach glandular epithelium morphology 0.177647785547194 0.374490564871732 0.860333627395942 0.5 18.1 18 1 abnormal mammary gland morphology 0.177647785547194 0.374490564871732 0.860333627395942 0.5 18.1 18 1 abnormal thymus cortex morphology 0.177647785547194 0.374490564871732 0.860333627395942 0.5 18.1 18 1 abnormal anterior eye segment morphology 0.177647785547194 0.374490564871732 0.860333627395942 0.5 18.1 18 1 abnormal eye anterior chamber morphology 0.177647785547194 0.374490564871732 0.860333627395942 0.5 18.1 18 1 decreased fluid intake 0.177647785547194 0.374490564871732 0.860333627395942 0.5 18.1 18 1 increased adipocyte glucose uptake 0.177647785547194 0.374490564871732 0.860333627395942 0.5 18.1 18 1 abnormal interparietal bone morphology 0.223629917036814 0.455406810175255 0.860333627395942 0.5 18.1 18 1 increased aggression towards males 0.223629917036814 0.455406810175255 0.860333627395942 0.5 18.1 18 1 abnormal placing response 0.223629917036814 0.455406810175255 0.860333627395942 0.5 18.1 18 1 abnormal antigen presentation 0.223629917036814 0.455406810175255 0.860333627395942 0.5 18.1 18 1 abnormal olfactory system physiology 0.223629917036814 0.455406810175255 0.860333627395942 0.5 18.1 18 1 absent otoliths 0.223629917036814 0.455406810175255 0.860333627395942 0.5 18.1 18 1 abnormal prepulse inhibition 0.223629917036814 0.455406810175255 0.860333627395942 0.5 18.1 18 1 skeletal muscle necrosis 0.223629917036814 0.455406810175255 0.860333627395942 0.5 18.1 18 1 abnormal pancreas development 0.223629917036814 0.455406810175255 0.860333627395942 0.5 18.1 18 1 abnormal iris pigmentation 0.223629917036814 0.455406810175255 0.860333627395942 0.5 18.1 18 1 increased pulmonary respiratory rate 0.223629917036814 0.455406810175255 0.860333627395942 0.5 18.1 18 1 abnormal epidermis suprabasal layer morphology 0.288198594526451 0.539090665413588 0.860333627395942 0.5 18.1 18 1 abnormal grooming behavior 0.288198594526451 0.539090665413588 0.860333627395942 0.5 18.1 18 1 decreased incidence of induced tumors 0.288198594526451 0.539090665413588 0.860333627395942 0.5 18.1 18 1 abnormal gland morphology 0.288198594526451 0.539090665413588 0.860333627395942 0.5 18.1 18 1 abnormal airway responsiveness 0.288198594526451 0.539090665413588 0.860333627395942 0.5 18.1 18 1 abnormal neuron specification 0.288198594526451 0.539090665413588 0.860333627395942 0.5 18.1 18 1 abnormal bone healing 0.288198594526451 0.539090665413588 0.860333627395942 0.5 18.1 18 1 abnormal hypaxial muscle morphology 0.288198594526451 0.539090665413588 0.860333627395942 0.5 18.1 18 1 abnormal submandibular gland morphology 0.288198594526451 0.539090665413588 0.860333627395942 0.5 18.1 18 1 abnormal reproductive system development 0.288198594526451 0.539090665413588 0.860333627395942 0.5 18.1 18 1 abnormal embryonic erythrocyte morphology 0.288198594526451 0.539090665413588 0.860333627395942 0.5 18.1 18 1 abnormal utricular macula morphology 0.288198594526451 0.539090665413588 0.860333627395942 0.5 18.1 18 1 ascites 0.288198594526451 0.539090665413588 0.860333627395942 0.5 18.1 18 1 increased susceptibility to atherosclerosis 0.288198594526451 0.539090665413588 0.860333627395942 0.5 18.1 18 1 increased platelet aggregation 0.288198594526451 0.539090665413588 0.860333627395942 0.5 18.1 18 1 abnormal spinal cord dorsal column morphology 0.288198594526451 0.539090665413588 0.860333627395942 0.5 18.1 18 1 abnormal sperm principal piece morphology 0.288198594526451 0.539090665413588 0.860333627395942 0.5 18.1 18 1 decreased transitional stage T2 B cell number 0.288198594526451 0.539090665413588 0.860333627395942 0.5 18.1 18 1 abnormal hippocampus neuron morphology 0.288198594526451 0.539090665413588 0.860333627395942 0.5 18.1 18 1 umbilical hernia 0.288198594526451 0.539090665413588 0.860333627395942 0.5 18.1 18 1 acanthocytosis 0.288198594526451 0.539090665413588 0.860333627395942 0.5 18.1 18 1 increased kidney iron level 0.288198594526451 0.539090665413588 0.860333627395942 0.5 18.1 18 1 common ventricle 0.288198594526451 0.539090665413588 0.860333627395942 0.5 18.1 18 1 sinus bradycardia 0.288198594526451 0.539090665413588 0.860333627395942 0.5 18.1 18 1 abnormal pulmonary interalveolar septum morphology 0.288198594526451 0.539090665413588 0.860333627395942 0.5 18.1 18 1 increased compact bone area 0.288198594526451 0.539090665413588 0.860333627395942 0.5 18.1 18 1 decreased macrophage apoptosis 0.288198594526451 0.539090665413588 0.860333627395942 0.5 18.1 18 1 short femur 0.00747715151086862 0.0403896077812936 0.860333627395942 0.5 18.1 18 1 increased T cell number 0.00747715151086862 0.0403896077812936 0.860333627395942 0.5 18.1 18 1 parakeratosis 0.143188980111856 0.307879599114286 0.860333627395942 0.5 18.1 18 1 abnormal retinal outer plexiform layer morphology 0.143188980111856 0.307879599114286 0.860333627395942 0.5 18.1 18 1 abnormal mesenteric lymph node morphology 0.143188980111856 0.307879599114286 0.860333627395942 0.5 18.1 18 1 impaired humoral immune response 0.143188980111856 0.307879599114286 0.860333627395942 0.5 18.1 18 1 increased anxiety-related response 0.00125788881102843 0.00962768743825606 0.854144176839137 0.496402877697842 18.1 18 1 hyperkeratosis 0.0222895979980644 0.091494018185124 0.847865024100349 0.492753623188406 18.1 18 1 abnormal NK cell physiology 0.0314787298153291 0.119391440160807 0.846229797438631 0.491803278688525 18.1 18 1 increased B cell proliferation 0.0343488451425656 0.120919890617561 0.845751701507875 0.491525423728814 18.1 18 1 abnormal cartilage development 0.0641597297143797 0.19207300045873 0.841215102342699 0.488888888888889 18.1 18 1 altered response to myocardial infarction 0.0641597297143797 0.19207300045873 0.841215102342699 0.488888888888889 18.1 18 1 abnormal axon guidance 0.0703250070832527 0.199581808465021 0.840325868619292 0.488372093023256 18.1 18 1 abnormal cholesterol homeostasis 0.0771433755655491 0.217197675969783 0.839349880386285 0.48780487804878 18.1 18 1 increased brown adipose tissue amount 0.0930750450182602 0.25739207835789 0.837081367196052 0.486486486486487 18.1 18 1 impaired skeletal muscle contractility 0.0930750450182602 0.25739207835789 0.837081367196052 0.486486486486487 18.1 18 1 decreased susceptibility to injury 0.030858220745575 0.11898842428537 0.835029697178414 0.485294117647059 18.1 18 1 increased total body fat amount 0.00347896824525206 0.0218809949685575 0.834652026578153 0.485074626865672 18.1 18 1 abnormal middle ear ossicle morphology 0.112767555792008 0.302599023767659 0.834262911414247 0.484848484848485 18.1 18 1 abnormal T cell proliferation 0.124356941975971 0.307879599114286 0.832580929738008 0.483870967741935 18.1 18 1 decreased susceptibility to bacterial infection induced morbidity/mortality 0.124356941975971 0.307879599114286 0.832580929738008 0.483870967741935 18.1 18 1 increased sensitivity to induced morbidity/mortality 0.000808050587330024 0.00676048170534494 0.832279269980857 0.483695652173913 18.1 18 1 decreased retinal photoreceptor cell number 0.137335973299218 0.307879599114286 0.830666950589185 0.482758620689655 18.1 18 1 short sternum 0.137335973299218 0.307879599114286 0.830666950589185 0.482758620689655 18.1 18 1 abnormal CD8-positive, alpha-beta T cell physiology 0.137335973299218 0.307879599114286 0.830666950589185 0.482758620689655 18.1 18 1 enlarged epididymis 0.137335973299218 0.307879599114286 0.830666950589185 0.482758620689655 18.1 18 1 increased double-positive T cell number 0.137335973299218 0.307879599114286 0.830666950589185 0.482758620689655 18.1 18 1 enhanced long term potentiation 0.0520231668075671 0.166977583785578 0.829607426417515 0.482142857142857 18.1 18 1 decreased susceptibility to pharmacologically induced seizures 0.151918120289922 0.323957414677395 0.82846941897387 0.481481481481481 18.1 18 1 increased susceptibility to injury 0.0621374508490935 0.19207300045873 0.827243872496098 0.480769230769231 18.1 18 1 abnormal vertebrae development 0.168362816376738 0.356124579708449 0.825920282300104 0.48 18.1 18 1 increased susceptibility to pharmacologically induced seizures 0.0162162337885679 0.0732749891899412 0.824486392921111 0.479166666666667 18.1 18 1 abnormal lymph node morphology 0.0743828891559529 0.209544096008418 0.824486392921111 0.479166666666667 18.1 18 1 abnormal CD4-positive, alpha-beta T cell physiology 0.0355434116706229 0.124439460282441 0.823981502294705 0.47887323943662 18.1 18 1 abnormal sleep pattern 0.0814592772918951 0.227802082364912 0.822927817509162 0.478260869565217 18.1 18 1 delayed wound healing 0.0814592772918951 0.227802082364912 0.822927817509162 0.478260869565217 18.1 18 1 abnormal crista ampullaris morphology 0.18698974124967 0.389725162428617 0.822927817509162 0.478260869565217 18.1 18 1 dilated heart 0.18698974124967 0.389725162428617 0.822927817509162 0.478260869565217 18.1 18 1 abnormal corneal stroma morphology 0.18698974124967 0.389725162428617 0.822927817509162 0.478260869565217 18.1 18 1 abnormal nervous system electrophysiology 0.0266389043041576 0.108010227313108 0.819365359424707 0.476190476190476 18.1 18 1 increased acute inflammation 0.208199307984114 0.426251669638258 0.819365359424707 0.476190476190476 18.1 18 1 decreased vocalization 0.208199307984114 0.426251669638258 0.819365359424707 0.476190476190476 18.1 18 1 increased double-negative T cell number 0.0546600593989607 0.174428348627216 0.81802213752401 0.475409836065574 18.1 18 1 abnormal social investigation 0.031479770323798 0.119391440160807 0.817316946026145 0.475 18.1 18 1 impaired ovarian folliculogenesis 0.107462107793906 0.288829814302907 0.817316946026145 0.475 18.1 18 1 head bobbing 0.107462107793906 0.288829814302907 0.817316946026145 0.475 18.1 18 1 increased susceptibility to weight loss 0.107462107793906 0.288829814302907 0.817316946026145 0.475 18.1 18 1 abnormal stationary movement 0.232502958145765 0.463793992291573 0.815052910164577 0.473684210526316 18.1 18 1 altered susceptibility to infection 0.232502958145765 0.463793992291573 0.815052910164577 0.473684210526316 18.1 18 1 increased left ventricle weight 0.232502958145765 0.463793992291573 0.815052910164577 0.473684210526316 18.1 18 1 Leydig cell hypoplasia 0.232502958145765 0.463793992291573 0.815052910164577 0.473684210526316 18.1 18 1 decreased liver glycogen level 0.232502958145765 0.463793992291573 0.815052910164577 0.473684210526316 18.1 18 1 impaired natural killer cell mediated cytotoxicity 0.0650968197177389 0.192542614801279 0.815052910164576 0.473684210526316 18.1 18 1 abnormal inhibitory postsynaptic currents 0.0522399326344072 0.167565225568134 0.809725766960887 0.470588235294118 18.1 18 1 abnormal retinal photoreceptor morphology 0.142920491878703 0.307879599114286 0.809725766960887 0.470588235294118 18.1 18 1 decreased osteoblast cell number 0.142920491878703 0.307879599114286 0.809725766960887 0.470588235294118 18.1 18 1 abnormal tendon morphology 0.2605695896706 0.504069533531839 0.809725766960887 0.470588235294118 18.1 18 1 abnormal circulating chemokine level 0.2605695896706 0.504069533531839 0.809725766960887 0.470588235294118 18.1 18 1 common atrium 0.2605695896706 0.504069533531839 0.809725766960887 0.470588235294118 18.1 18 1 abnormal electroretinogram waveform feature 0.2605695896706 0.504069533531839 0.809725766960887 0.470588235294118 18.1 18 1 increased fluid intake 0.0928419711914663 0.257033281400971 0.807660140004354 0.469387755102041 18.1 18 1 decreased food intake 0.0420754912500267 0.145292336401126 0.805882131991135 0.468354430379747 18.1 18 1 increased circulating glucose level 0.00901497188669289 0.0466210864202673 0.805418715008967 0.468085106382979 18.1 18 1 decreased bone trabecula number 0.101595464540436 0.277712876971797 0.805418715008967 0.468085106382979 18.1 18 1 obese 0.0457293980118529 0.156359969147057 0.804467807435166 0.467532467532468 18.1 18 1 increased circulating corticosterone level 0.111242905516006 0.298668890956357 0.802978052236213 0.466666666666667 18.1 18 1 abnormal fontanelle morphology 0.293299793188433 0.539090665413588 0.802978052236212 0.466666666666667 18.1 18 1 decreased chondrocyte number 0.293299793188433 0.539090665413588 0.802978052236212 0.466666666666667 18.1 18 1 decreased salivation 0.293299793188433 0.539090665413588 0.802978052236212 0.466666666666667 18.1 18 1 abnormal enteric neuron morphology 0.293299793188433 0.539090665413588 0.802978052236212 0.466666666666667 18.1 18 1 abnormal apical ectodermal ridge morphology 0.293299793188433 0.539090665413588 0.802978052236212 0.466666666666667 18.1 18 1 abnormal ear development 0.293299793188433 0.539090665413588 0.802978052236212 0.466666666666667 18.1 18 1 ostium primum atrial septal defect 0.293299793188433 0.539090665413588 0.802978052236212 0.466666666666667 18.1 18 1 increased food intake 0.0434418878879899 0.149359635274879 0.798881225439089 0.464285714285714 18.1 18 1 abnormal jaw morphology 0.192160579250539 0.400166965998924 0.798881225439089 0.464285714285714 18.1 18 1 abnormal spleen germinal center morphology 0.192160579250539 0.400166965998924 0.798881225439089 0.464285714285714 18.1 18 1 increased vascular permeability 0.146653896673687 0.313268843259594 0.794154117596254 0.461538461538462 18.1 18 1 decreased trabecular bone volume 0.146653896673687 0.313268843259594 0.794154117596254 0.461538461538462 18.1 18 1 no spontaneous movement 0.212754001560962 0.43521840368659 0.794154117596254 0.461538461538462 18.1 18 1 abnormal mast cell morphology 0.331950798287666 0.539090665413588 0.794154117596254 0.461538461538462 18.1 18 1 small trigeminal ganglion 0.331950798287666 0.539090665413588 0.794154117596254 0.461538461538462 18.1 18 1 uterus hypoplasia 0.331950798287666 0.539090665413588 0.794154117596254 0.461538461538462 18.1 18 1 pup cannibalization 0.331950798287666 0.539090665413588 0.794154117596254 0.461538461538462 18.1 18 1 abnormal digestion 0.331950798287666 0.539090665413588 0.794154117596254 0.461538461538462 18.1 18 1 abnormal intercostal muscle morphology 0.331950798287666 0.539090665413588 0.794154117596254 0.461538461538462 18.1 18 1 abnormal soleus morphology 0.331950798287666 0.539090665413588 0.794154117596254 0.461538461538462 18.1 18 1 abnormal dopaminergic neuron morphology 0.331950798287666 0.539090665413588 0.794154117596254 0.461538461538462 18.1 18 1 abnormal insulin secretion 0.331950798287666 0.539090665413588 0.794154117596254 0.461538461538462 18.1 18 1 hyperalgesia 0.331950798287666 0.539090665413588 0.794154117596254 0.461538461538462 18.1 18 1 increased renin activity 0.331950798287666 0.539090665413588 0.794154117596254 0.461538461538462 18.1 18 1 abnormal hair follicle inner root sheath morphology 0.331950798287666 0.539090665413588 0.794154117596254 0.461538461538462 18.1 18 1 abnormal immune system physiology 0.0218205003467355 0.0900140872512513 0.790951883251108 0.459677419354839 18.1 18 1 abnormal T cell activation 0.0655610123913502 0.193522278058019 0.790576846796271 0.459459459459459 18.1 18 1 abnormal body weight 0.236005889139108 0.469463933813299 0.78863915844628 0.458333333333333 18.1 18 1 abnormal cardiac muscle contractility 0.236005889139108 0.469463933813299 0.78863915844628 0.458333333333333 18.1 18 1 abnormal humoral immune response 0.0367790873907767 0.128404182294115 0.786590745047718 0.457142857142857 18.1 18 1 abnormal T cell subpopulation ratio 0.194822570800373 0.405371095663678 0.782121479450856 0.454545454545455 18.1 18 1 decreased sensitivity to xenobiotic induced morbidity/mortality 0.194822570800373 0.405371095663678 0.782121479450856 0.454545454545455 18.1 18 1 abnormal circadian rhythm 0.149068041587082 0.318289058753534 0.782121479450856 0.454545454545455 18.1 18 1 increased coping response 0.262374581210996 0.504069533531839 0.782121479450856 0.454545454545455 18.1 18 1 abnormal circulating lipid level 0.262374581210996 0.504069533531839 0.782121479450856 0.454545454545455 18.1 18 1 abnormal ear position 0.378360507081265 0.552817480977766 0.782121479450856 0.454545454545455 18.1 18 1 increased mast cell number 0.378360507081265 0.552817480977766 0.782121479450856 0.454545454545455 18.1 18 1 abnormal large intestine morphology 0.378360507081265 0.552817480977766 0.782121479450856 0.454545454545455 18.1 18 1 abnormal enteric ganglia morphology 0.378360507081265 0.552817480977766 0.782121479450856 0.454545454545455 18.1 18 1 abnormal hypothalamus secretion 0.378360507081265 0.552817480977766 0.782121479450856 0.454545454545455 18.1 18 1 secondary sex reversal 0.378360507081265 0.552817480977766 0.782121479450856 0.454545454545455 18.1 18 1 dilated renal glomerular capsule 0.378360507081265 0.552817480977766 0.782121479450856 0.454545454545455 18.1 18 1 abnormal pituitary gland development 0.378360507081265 0.552817480977766 0.782121479450856 0.454545454545455 18.1 18 1 enlarged placenta 0.378360507081265 0.552817480977766 0.782121479450856 0.454545454545455 18.1 18 1 abnormal crista ampullaris neuroepithelium morphology 0.378360507081265 0.552817480977766 0.782121479450856 0.454545454545455 18.1 18 1 increased motor neuron number 0.378360507081265 0.552817480977766 0.782121479450856 0.454545454545455 18.1 18 1 abnormal extraembryonic ectoderm morphology 0.378360507081265 0.552817480977766 0.782121479450856 0.454545454545455 18.1 18 1 abnormal brain ependyma motile cilium morphology 0.378360507081265 0.552817480977766 0.782121479450856 0.454545454545455 18.1 18 1 decreased inflammatory response 0.0679778888090112 0.193522278058019 0.778397091453471 0.452380952380952 18.1 18 1 abnormal fibula morphology 0.292432478734446 0.539090665413588 0.774300264656348 0.45 18.1 18 1 abnormal male reproductive system physiology 0.292432478734446 0.539090665413588 0.774300264656348 0.45 18.1 18 1 abnormal heart right ventricle morphology 0.292432478734446 0.539090665413588 0.774300264656348 0.45 18.1 18 1 decreased circulating VLDL cholesterol level 0.292432478734446 0.539090665413588 0.774300264656348 0.45 18.1 18 1 nuclear cataracts 0.292432478734446 0.539090665413588 0.774300264656348 0.45 18.1 18 1 abnormal middle ear morphology 0.236705571585986 0.470103879696719 0.771333596975672 0.448275862068966 18.1 18 1 abnormal parietal bone morphology 0.236705571585986 0.470103879696719 0.771333596975672 0.448275862068966 18.1 18 1 stomach inflammation 0.236705571585986 0.470103879696719 0.771333596975672 0.448275862068966 18.1 18 1 increased retinal apoptosis 0.236705571585986 0.470103879696719 0.771333596975672 0.448275862068966 18.1 18 1 abnormal femur morphology 0.109081662048158 0.293024443136924 0.770448024533679 0.447761194029851 18.1 18 1 abnormal tibia morphology 0.164260363315039 0.347742684039285 0.76880877341765 0.446808510638298 18.1 18 1 increased systemic arterial blood pressure 0.164260363315039 0.347742684039285 0.76880877341765 0.446808510638298 18.1 18 1 polyphagia 0.151240634451866 0.322651010462279 0.764741002129726 0.444444444444444 18.1 18 1 increased circulating glycerol level 0.326907032969326 0.539090665413588 0.764741002129726 0.444444444444444 18.1 18 1 long tibia 0.326907032969326 0.539090665413588 0.764741002129726 0.444444444444444 18.1 18 1 decreased IgA level 0.164601922051184 0.348317550916479 0.76106436269641 0.442307692307692 18.1 18 1 lung hemorrhage 0.235797896264849 0.469425583800569 0.759117906525831 0.441176470588235 18.1 18 1 abnormal bone remodeling 0.235797896264849 0.469425583800569 0.759117906525831 0.441176470588235 18.1 18 1 decreased cytotoxic T cell cytolysis 0.235797896264849 0.469425583800569 0.759117906525831 0.441176470588235 18.1 18 1 increased susceptibility to weight gain 0.235797896264849 0.469425583800569 0.759117906525831 0.441176470588235 18.1 18 1 decreased eosinophil cell number 0.151164323194323 0.322626558512122 0.752791923971449 0.4375 18.1 18 1 abnormal tympanic ring morphology 0.366741939021092 0.539090665413588 0.752791923971449 0.4375 18.1 18 1 delayed hair appearance 0.366741939021092 0.539090665413588 0.752791923971449 0.4375 18.1 18 1 decreased cochlear coiling 0.366741939021092 0.539090665413588 0.752791923971449 0.4375 18.1 18 1 decreased aggression towards mice 0.366741939021092 0.539090665413588 0.752791923971449 0.4375 18.1 18 1 abnormal wound healing 0.366741939021092 0.539090665413588 0.752791923971449 0.4375 18.1 18 1 decreased circulating prolactin level 0.366741939021092 0.539090665413588 0.752791923971449 0.4375 18.1 18 1 abnormal pancreatic alpha cell morphology 0.366741939021092 0.539090665413588 0.752791923971449 0.4375 18.1 18 1 abnormal fertilization 0.366741939021092 0.539090665413588 0.752791923971449 0.4375 18.1 18 1 abnormal urinary bladder physiology 0.366741939021092 0.539090665413588 0.752791923971449 0.4375 18.1 18 1 increased heart left ventricle size 0.366741939021092 0.539090665413588 0.752791923971449 0.4375 18.1 18 1 decreased adipocyte glucose uptake 0.366741939021092 0.539090665413588 0.752791923971449 0.4375 18.1 18 1 abnormal leukocyte adhesion 0.233913511016202 0.466420728378999 0.750034444396462 0.435897435897436 18.1 18 1 abnormal immune system morphology 0.212456609843703 0.43478882516348 0.748116197735602 0.434782608695652 18.1 18 1 fragile skeleton 0.320362919642786 0.539090665413588 0.748116197735602 0.434782608695652 18.1 18 1 abnormal eye physiology 0.177378488999895 0.374490564871732 0.745622477076483 0.433333333333333 18.1 18 1 abnormal estrous cycle 0.284769232944524 0.539090665413588 0.745622477076483 0.433333333333333 18.1 18 1 abnormal synaptic transmission 0.284769232944524 0.539090665413588 0.745622477076483 0.433333333333333 18.1 18 1 abnormal photoreceptor outer segment morphology 0.231414426171056 0.462549927762557 0.743015405478313 0.431818181818182 18.1 18 1 decreased macrophage cell number 0.231414426171056 0.462549927762557 0.743015405478313 0.431818181818182 18.1 18 1 abnormal eye electrophysiology 0.0931319589716931 0.257406386602318 0.739460307844446 0.429752066115702 18.1 18 1 increased vasoconstriction 0.355607356797195 0.539090665413588 0.737428823482236 0.428571428571429 18.1 18 1 hypoalgesia 0.355607356797195 0.539090665413588 0.737428823482236 0.428571428571429 18.1 18 1 impaired behavioral response to xenobiotic 0.279857796834812 0.536115725549939 0.737428823482236 0.428571428571429 18.1 18 1 abnormal vasoconstriction 0.413191459225806 0.592229187452718 0.737428823482236 0.428571428571429 18.1 18 1 megacephaly 0.413191459225806 0.592229187452718 0.737428823482236 0.428571428571429 18.1 18 1 absent visceral yolk sac blood islands 0.413191459225806 0.592229187452718 0.737428823482236 0.428571428571429 18.1 18 1 abnormal spleen periarteriolar lymphoid sheath morphology 0.413191459225806 0.592229187452718 0.737428823482236 0.428571428571429 18.1 18 1 abnormal endplate potential 0.413191459225806 0.592229187452718 0.737428823482236 0.428571428571429 18.1 18 1 decreased coping response 0.413191459225806 0.592229187452718 0.737428823482236 0.428571428571429 18.1 18 1 abnormal voluntary movement 0.413191459225806 0.592229187452718 0.737428823482236 0.428571428571429 18.1 18 1 abnormal hair cuticle 0.413191459225806 0.592229187452718 0.737428823482236 0.428571428571429 18.1 18 1 abnormal positive T cell selection 0.413191459225806 0.592229187452718 0.737428823482236 0.428571428571429 18.1 18 1 abnormal skeleton physiology 0.306319540315954 0.539090665413588 0.729980047487466 0.424242424242424 18.1 18 1 abnormal leukocyte cell number 0.345180696268023 0.539090665413588 0.727974607796566 0.423076923076923 18.1 18 1 decreased Peyer's patch number 0.345180696268023 0.539090665413588 0.727974607796566 0.423076923076923 18.1 18 1 hyporesponsive to tactile stimuli 0.299378120185556 0.539090665413588 0.724491475701846 0.421052631578947 18.1 18 1 decreased chemically-elicited antinociception 0.395564541931915 0.568766935292277 0.724491475701846 0.421052631578947 18.1 18 1 abnormal ear morphology 0.395564541931915 0.568766935292277 0.724491475701846 0.421052631578947 18.1 18 1 abnormal photoreceptor inner segment morphology 0.395564541931915 0.568766935292277 0.724491475701846 0.421052631578947 18.1 18 1 impaired macrophage phagocytosis 0.292616113897958 0.539090665413588 0.720279315959393 0.418604651162791 18.1 18 1 abnormal malleus morphology 0.380617941431127 0.555300369096732 0.716944689496618 0.416666666666667 18.1 18 1 abnormal adrenal gland morphology 0.380617941431127 0.555300369096732 0.716944689496618 0.416666666666667 18.1 18 1 decreased fatty acid level 0.380617941431127 0.555300369096732 0.716944689496618 0.416666666666667 18.1 18 1 increased circulating total protein level 0.380617941431127 0.555300369096732 0.716944689496618 0.416666666666667 18.1 18 1 abnormal cellular extravasation 0.380617941431127 0.555300369096732 0.716944689496618 0.416666666666667 18.1 18 1 abnormal supraoccipital bone morphology 0.467970945077103 0.638370693832772 0.716944689496618 0.416666666666667 18.1 18 1 decreased digestive secretion 0.467970945077103 0.638370693832772 0.716944689496618 0.416666666666667 18.1 18 1 absent optic nerve 0.467970945077103 0.638370693832772 0.716944689496618 0.416666666666667 18.1 18 1 ear inflammation 0.467970945077103 0.638370693832772 0.716944689496618 0.416666666666667 18.1 18 1 abnormal tracheal ciliated epithelium morphology 0.467970945077103 0.638370693832772 0.716944689496618 0.416666666666667 18.1 18 1 abnormal gastrocnemius morphology 0.467970945077103 0.638370693832772 0.716944689496618 0.416666666666667 18.1 18 1 increased fear-related response 0.467970945077103 0.638370693832772 0.716944689496618 0.416666666666667 18.1 18 1 impaired sperm capacitation 0.467970945077103 0.638370693832772 0.716944689496618 0.416666666666667 18.1 18 1 decreased left ventricle systolic pressure 0.467970945077103 0.638370693832772 0.716944689496618 0.416666666666667 18.1 18 1 decreased cochlear nerve compound action potential 0.467970945077103 0.638370693832772 0.716944689496618 0.416666666666667 18.1 18 1 abnormal patella morphology 0.467970945077103 0.638370693832772 0.716944689496618 0.416666666666667 18.1 18 1 decreased oligodendrocyte number 0.467970945077103 0.638370693832772 0.716944689496618 0.416666666666667 18.1 18 1 impaired wound healing 0.326304724978516 0.539090665413588 0.716944689496618 0.416666666666667 18.1 18 1 decreased monocyte cell number 0.2490135108372 0.494350445496835 0.714738705836629 0.415384615384615 18.1 18 1 increased susceptibility to induced arthritis 0.367484876534823 0.539090665413588 0.712000243362159 0.413793103448276 18.1 18 1 decreased regulatory T cell number 0.355684691151727 0.539090665413588 0.708510046090776 0.411764705882353 18.1 18 1 increased aggression towards mice 0.441062583566435 0.625509222703254 0.708510046090776 0.411764705882353 18.1 18 1 abnormal cranial suture morphology 0.441062583566435 0.625509222703254 0.708510046090776 0.411764705882353 18.1 18 1 decreased growth hormone level 0.441062583566435 0.625509222703254 0.708510046090776 0.411764705882353 18.1 18 1 pancytopenia 0.441062583566435 0.625509222703254 0.708510046090776 0.411764705882353 18.1 18 1 hypertension 0.334986513093505 0.539090665413588 0.703909331505771 0.409090909090909 18.1 18 1 abnormal basisphenoid bone morphology 0.420153124510718 0.60168733288452 0.703909331505771 0.409090909090909 18.1 18 1 abnormal female reproductive system physiology 0.420153124510718 0.60168733288452 0.703909331505771 0.409090909090909 18.1 18 1 decreased susceptibility to viral infection induced morbidity/mortality 0.420153124510718 0.60168733288452 0.703909331505771 0.409090909090909 18.1 18 1 wrinkled skin 0.402764314180056 0.57878465137082 0.701012585285582 0.407407407407407 18.1 18 1 salivary gland inflammation 0.422628638928356 0.605058267242755 0.688266901916754 0.4 18.1 18 1 abnormal lymph node B cell domain morphology 0.493119236584053 0.670658338437853 0.688266901916754 0.4 18.1 18 1 greasy coat 0.493119236584053 0.670658338437853 0.688266901916754 0.4 18.1 18 1 decreased aggression towards males 0.493119236584053 0.670658338437853 0.688266901916754 0.4 18.1 18 1 abnormal aorta wall morphology 0.493119236584053 0.670658338437853 0.688266901916754 0.4 18.1 18 1 lactation failure 0.493119236584053 0.670658338437853 0.688266901916754 0.4 18.1 18 1 abnormal microglial cell activation 0.493119236584053 0.670658338437853 0.688266901916754 0.4 18.1 18 1 decreased trabecular bone mass 0.493119236584053 0.670658338437853 0.688266901916754 0.4 18.1 18 1 brain inflammation 0.464319250730228 0.638370693832772 0.688266901916753 0.4 18.1 18 1 decreased skin tensile strength 0.464319250730228 0.638370693832772 0.688266901916753 0.4 18.1 18 1 abnormal thymocyte activation 0.464319250730228 0.638370693832772 0.688266901916753 0.4 18.1 18 1 abnormal basicranium morphology 0.484303970497245 0.659932142761927 0.673304577962042 0.391304347826087 18.1 18 1 increased susceptibility to bacterial infection induced morbidity/mortality 0.396154674448268 0.569450882802697 0.66914837686351 0.388888888888889 18.1 18 1 abnormal retinal rod cell morphology 0.513707024855505 0.693163126839202 0.66914837686351 0.388888888888889 18.1 18 1 abnormal Peyer's patch follicle morphology 0.513707024855505 0.693163126839202 0.66914837686351 0.388888888888889 18.1 18 1 abnormal sperm axoneme morphology 0.513707024855505 0.693163126839202 0.66914837686351 0.388888888888889 18.1 18 1 impaired leukocyte tethering or rolling 0.513707024855505 0.693163126839202 0.66914837686351 0.388888888888889 18.1 18 1 abnormal body temperature homeostasis 0.477697390474049 0.651108087015998 0.666064743790407 0.387096774193548 18.1 18 1 abnormal lens fiber morphology 0.472270765042735 0.643887929867801 0.661795097996878 0.384615384615385 18.1 18 1 small seminal vesicle 0.501852136992166 0.682348833434278 0.661795097996878 0.384615384615385 18.1 18 1 tight skin 0.5529835368205 0.74213463600809 0.661795097996878 0.384615384615385 18.1 18 1 abnormal lung interstitium morphology 0.5529835368205 0.74213463600809 0.661795097996878 0.384615384615385 18.1 18 1 absent lateral semicircular canal 0.5529835368205 0.74213463600809 0.661795097996878 0.384615384615385 18.1 18 1 small interparietal bone 0.5529835368205 0.74213463600809 0.661795097996878 0.384615384615385 18.1 18 1 decreased luteinizing hormone level 0.5529835368205 0.74213463600809 0.661795097996878 0.384615384615385 18.1 18 1 increased circulating ammonia level 0.5529835368205 0.74213463600809 0.661795097996878 0.384615384615385 18.1 18 1 abnormal T-helper 1 physiology 0.467589103283875 0.638370693832772 0.6589789486437 0.382978723404255 18.1 18 1 increased susceptibility to parasitic infection 0.459612725997261 0.638370693832772 0.650029851810267 0.377777777777778 18.1 18 1 decreased susceptibility to parasitic infection 0.531682087169735 0.717154842555681 0.645250220546956 0.375 18.1 18 1 abnormal pituitary gland morphology 0.568945615121831 0.745704455796155 0.645250220546956 0.375 18.1 18 1 mixed cellular infiltration to dermis 0.568945615121831 0.745704455796155 0.645250220546956 0.375 18.1 18 1 abnormal intestinal lipid absorption 0.568945615121831 0.745704455796155 0.645250220546956 0.375 18.1 18 1 dilated respiratory conducting tubes 0.568945615121831 0.745704455796155 0.645250220546956 0.375 18.1 18 1 abnormal response to novelty 0.582623473227598 0.745704455796155 0.633930041239115 0.368421052631579 18.1 18 1 abnormal behavioral response to xenobiotic 0.582623473227598 0.745704455796155 0.633930041239115 0.368421052631579 18.1 18 1 increased activated T cell number 0.594685022483211 0.745704455796155 0.625697183560685 0.363636363636364 18.1 18 1 abnormal energy expenditure 0.605534042711541 0.746230335023512 0.619440211725078 0.36 18.1 18 1 impaired conditioned place preference behavior 0.605534042711541 0.746230335023512 0.619440211725078 0.36 18.1 18 1 increased autoantibody level 0.603749611593799 0.745704455796155 0.617675424797086 0.358974358974359 18.1 18 1 abnormal circulating cholesterol level 0.615434061612097 0.754691756598516 0.61452401956853 0.357142857142857 18.1 18 1 extended life span 0.630645802150885 0.771633759395144 0.61452401956853 0.357142857142857 18.1 18 1 decreased cornea thickness 0.630645802150885 0.771633759395144 0.61452401956853 0.357142857142857 18.1 18 1 abnormal urinary bladder morphology 0.638699995970228 0.781296405200857 0.607294325220665 0.352941176470588 18.1 18 1 enhanced behavioral response to xenobiotic 0.646325746880028 0.790430332037399 0.602233539177159 0.35 18.1 18 1 increased susceptibility to fungal infection 0.653554916875727 0.799074886079318 0.598492958188481 0.347826086956522 18.1 18 1 abnormal food intake 0.675833659597393 0.825908242814303 0.598492958188481 0.347826086956522 18.1 18 1 abnormal diaphragm morphology 0.673221213520004 0.822917822423101 0.59147936883471 0.34375 18.1 18 1 abnormal seizure response to electrical stimulation 0.699409084934301 0.851998089507382 0.573555751597295 0.333333333333333 18.1 18 1 arthritis 0.699409084934301 0.851998089507382 0.573555751597295 0.333333333333333 18.1 18 1 increased alcohol consumption 0.699409084934301 0.851998089507382 0.573555751597295 0.333333333333333 18.1 18 1 abnormal rostral migratory stream morphology 0.699409084934301 0.851998089507382 0.573555751597295 0.333333333333333 18.1 18 1 increased susceptibility to autoimmune disorder 0.70119648152759 0.852640215923402 0.573555751597295 0.333333333333333 18.1 18 1 abnormal macrophage chemotaxis 0.70119648152759 0.852640215923402 0.573555751597295 0.333333333333333 18.1 18 1 abnormal single cell response 0.710567149285995 0.856462159794719 0.573555751597295 0.333333333333333 18.1 18 1 arrested T cell differentiation 0.714228152426917 0.857866986558163 0.573555751597295 0.333333333333333 18.1 18 1 abnormal systemic arterial blood pressure 0.721763118748262 0.866708065598022 0.573555751597295 0.333333333333333 18.1 18 1 intestinal ulcer 0.754836455615539 0.878640937456085 0.547485035615599 0.318181818181818 18.1 18 1 decreased grooming behavior 0.755922485358356 0.879699266586624 0.543368606776384 0.315789473684211 18.1 18 1 impaired muscle relaxation 0.758710662121788 0.882531106863665 0.537708517122464 0.3125 18.1 18 1 increased circulating estradiol level 0.758710662121788 0.882531106863665 0.537708517122464 0.3125 18.1 18 1 abnormal circulating cytokine level 0.802892516134782 0.927418218660446 0.516200176437565 0.3 18.1 18 1 abnormal touch/ nociception 0.808715106351604 0.93392703205646 0.506078604350554 0.294117647058824 18.1 18 1 autoimmune response 0.860416294167152 0.976985751062021 0.499548557842805 0.290322580645161 18.1 18 1 decreased acute inflammation 0.86902640591364 0.986178460178002 0.481786831341728 0.28 18.1 18 1 decreased airway responsiveness 0.875370872913239 0.992925237743585 0.469272887670514 0.272727272727273 18.1 18 1 abnormal channel response 0.875370872913239 0.992925237743585 0.469272887670514 0.272727272727273 18.1 18 1 abnormal innervation pattern to muscle 0.902273370830544 1 0.448869718641361 0.260869565217391 18.1 18 1 increased susceptibility to age related obesity 0.902273370830544 1 0.448869718641361 0.260869565217391 18.1 18 1 abnormal stomach mucosa morphology 0.941375051237591 1 0.412960141150052 0.24 18.1 18 1 decreased Paneth cell number 0.000349977389437027 0.00419034320631349 3.91011723838472 1 19.1 19 1 decreased small intestinal villus height 0.000349977389437027 0.00419034320631349 3.91011723838472 1 19.1 19 1 eye opacity 2.17500774212393e-05 0.000427694210160734 3.47565976745308 0.888888888888889 19.1 19 1 tau protein deposits 9.53313278792521e-05 0.00149613046119646 3.42135258358663 0.875 19.1 19 1 abnormal foramen magnum morphology 9.53313278792521e-05 0.00149613046119646 3.42135258358663 0.875 19.1 19 1 growth retardation of molars 0.000411662485233621 0.0047407890371233 3.35152906147261 0.857142857142857 19.1 19 1 aorta coarctation 0.000411662485233621 0.0047407890371233 3.35152906147261 0.857142857142857 19.1 19 1 increased cell nucleus count 0.000411662485233621 0.0047407890371233 3.35152906147261 0.857142857142857 19.1 19 1 loss of hippocampal neurons 0.00174368580885406 0.0145550954682029 3.25843103198726 0.833333333333333 19.1 19 1 esophageal atresia 0.00174368580885406 0.0145550954682029 3.25843103198726 0.833333333333333 19.1 19 1 fusion of middle ear ossicles 0.00174368580885406 0.0145550954682029 3.25843103198726 0.833333333333333 19.1 19 1 abnormal lambdoidal suture morphology 0.00174368580885406 0.0145550954682029 3.25843103198726 0.833333333333333 19.1 19 1 abnormal metopic suture morphology 0.00174368580885406 0.0145550954682029 3.25843103198726 0.833333333333333 19.1 19 1 abnormal olfactory bulb layer morphology 0.00174368580885406 0.0145550954682029 3.25843103198726 0.833333333333333 19.1 19 1 abnormal orbit morphology 0.00174368580885406 0.0145550954682029 3.25843103198726 0.833333333333333 19.1 19 1 bowed tibia 3.07452806426334e-07 1.07716740279649e-05 3.17697025618758 0.8125 19.1 19 1 abnormal olfactory nerve morphology 1.23340746670274e-06 3.63088884428766e-05 3.12809379070777 0.8 19.1 19 1 fused cornea and lens 8.91350120512088e-05 0.00141676257174046 3.12809379070777 0.8 19.1 19 1 ketoaciduria 8.91350120512088e-05 0.00141676257174046 3.12809379070777 0.8 19.1 19 1 abnormal posterior semicircular canal morphology 0.000352865704482296 0.00419034320631349 3.04120229652145 0.777777777777778 19.1 19 1 abnormal NMDA-mediated synaptic currents 0.000352865704482296 0.00419034320631349 3.04120229652145 0.777777777777778 19.1 19 1 decreased fear-related response 0.000352865704482296 0.00419034320631349 3.04120229652145 0.777777777777778 19.1 19 1 abnormal cerebellar layer morphology 0.000352865704482296 0.00419034320631349 3.04120229652145 0.777777777777778 19.1 19 1 iris coloboma 0.000352865704482296 0.00419034320631349 3.04120229652145 0.777777777777778 19.1 19 1 cerebellum atrophy 0.000352865704482296 0.00419034320631349 3.04120229652145 0.777777777777778 19.1 19 1 abnormal hypoglossal nerve morphology 0.00136065595729673 0.012174934150272 2.93258792878854 0.75 19.1 19 1 absent eyelids 0.00136065595729673 0.012174934150272 2.93258792878854 0.75 19.1 19 1 decreased aerobic running capacity 0.00136065595729673 0.012174934150272 2.93258792878854 0.75 19.1 19 1 early eyelid opening 0.00136065595729673 0.012174934150272 2.93258792878854 0.75 19.1 19 1 bowed fibula 0.00136065595729673 0.012174934150272 2.93258792878854 0.75 19.1 19 1 small frontal bone 0.00136065595729673 0.012174934150272 2.93258792878854 0.75 19.1 19 1 abnormal olfactory bulb glomerular layer morphology 0.00136065595729673 0.012174934150272 2.93258792878854 0.75 19.1 19 1 abnormal olfactory bulb mitral cell layer morphology 0.00136065595729673 0.012174934150272 2.93258792878854 0.75 19.1 19 1 impaired neuron differentiation 0.00136065595729673 0.012174934150272 2.93258792878854 0.75 19.1 19 1 premature suture closure 0.000268045318430026 0.00342808601334031 2.84372162791616 0.727272727272727 19.1 19 1 abnormal sphenoid bone morphology 0.000268045318430026 0.00342808601334031 2.84372162791616 0.727272727272727 19.1 19 1 abnormal eye distance/ position 0.000268045318430026 0.00342808601334031 2.84372162791616 0.727272727272727 19.1 19 1 abnormal radial glial cell morphology 0.000268045318430026 0.00342808601334031 2.84372162791616 0.727272727272727 19.1 19 1 abnormal coronal suture morphology 0.000268045318430026 0.00342808601334031 2.84372162791616 0.727272727272727 19.1 19 1 abnormal dorsal-ventral polarity of the somites 0.000268045318430026 0.00342808601334031 2.84372162791616 0.727272727272727 19.1 19 1 abnormal anterior eye segment morphology 3.10132831947916e-06 8.07806721958578e-05 2.82397356105563 0.722222222222222 19.1 19 1 abnormal sagittal suture morphology 5.4095313015348e-05 0.000933493909130899 2.79294088456051 0.714285714285714 19.1 19 1 abnormal vitelline vein topology 5.4095313015348e-05 0.000933493909130899 2.79294088456051 0.714285714285714 19.1 19 1 cochlear degeneration 0.00507374411790518 0.0340187021382457 2.79294088456051 0.714285714285714 19.1 19 1 failure of atrioventricular cushion closure 0.00507374411790518 0.0340187021382457 2.79294088456051 0.714285714285714 19.1 19 1 broad head 0.00507374411790518 0.0340187021382457 2.79294088456051 0.714285714285714 19.1 19 1 mammary gland hyperplasia 0.00507374411790518 0.0340187021382457 2.79294088456051 0.714285714285714 19.1 19 1 abnormal gastrulation movements 0.00507374411790518 0.0340187021382457 2.79294088456051 0.714285714285714 19.1 19 1 abnormal superior semicircular canal morphology 0.00507374411790518 0.0340187021382457 2.79294088456051 0.714285714285714 19.1 19 1 abnormal Purkinje cell innervation 0.00507374411790518 0.0340187021382457 2.79294088456051 0.714285714285714 19.1 19 1 absent deltoid tuberosity 0.00507374411790518 0.0340187021382457 2.79294088456051 0.714285714285714 19.1 19 1 abnormal talus morphology 0.00507374411790518 0.0340187021382457 2.79294088456051 0.714285714285714 19.1 19 1 increased thyroid-stimulating hormone level 0.00507374411790518 0.0340187021382457 2.79294088456051 0.714285714285714 19.1 19 1 enhanced behavioral response to alcohol 0.00507374411790518 0.0340187021382457 2.79294088456051 0.714285714285714 19.1 19 1 decreased brain cholesterol level 0.00507374411790518 0.0340187021382457 2.79294088456051 0.714285714285714 19.1 19 1 thick pulmonary valve 0.00507374411790518 0.0340187021382457 2.79294088456051 0.714285714285714 19.1 19 1 embryonic lethality at implantation, incomplete penetrance 0.00507374411790518 0.0340187021382457 2.79294088456051 0.714285714285714 19.1 19 1 ductus venosus stenosis 0.00507374411790518 0.0340187021382457 2.79294088456051 0.714285714285714 19.1 19 1 abnormal neuron specification 0.000968237320154832 0.00938982586309998 2.7370820668693 0.7 19.1 19 1 osteosclerosis 0.000968237320154832 0.00938982586309998 2.7370820668693 0.7 19.1 19 1 abnormal spinal cord dorsal column morphology 0.000968237320154832 0.00938982586309998 2.7370820668693 0.7 19.1 19 1 abnormal cerebellar granule cell migration 0.000968237320154832 0.00938982586309998 2.7370820668693 0.7 19.1 19 1 increased fatty acid oxidation 0.000968237320154832 0.00938982586309998 2.7370820668693 0.7 19.1 19 1 abnormal xiphoid process morphology 1.01233236555751e-07 4.09459635662488e-06 2.70700424195865 0.692307692307692 19.1 19 1 small interparietal bone 0.000191724129816533 0.00259898513852112 2.70700424195865 0.692307692307692 19.1 19 1 increased cochlear inner hair cell number 0.000191724129816533 0.00259898513852112 2.70700424195865 0.692307692307692 19.1 19 1 bowed radius 3.88192199479336e-05 0.000704838026426896 2.68820560138949 0.6875 19.1 19 1 increased cochlear outer hair cell number 3.88192199479336e-05 0.000704838026426896 2.68820560138949 0.6875 19.1 19 1 abnormal thoracic cage shape 3.88192199479336e-05 0.000704838026426896 2.68820560138949 0.6875 19.1 19 1 embryonic lethality between implantation and somite formation, incomplete penetrance 7.97781743899979e-06 0.000176398407817884 2.67534337363165 0.684210526315789 19.1 19 1 abnormal cochlear sensory epithelium morphology 1.65706215664449e-06 4.79295594727112e-05 2.6659890261714 0.681818181818182 19.1 19 1 abnormal rostral-caudal body axis extension 0.000659930267822227 0.00699252505035627 2.60674482558981 0.666666666666667 19.1 19 1 small parietal bone 0.000659930267822227 0.00699252505035627 2.60674482558981 0.666666666666667 19.1 19 1 reduced cerebellar foliation 0.000659930267822227 0.00699252505035627 2.60674482558981 0.666666666666667 19.1 19 1 increased muscle cell glucose uptake 5.5996927523023e-06 0.000130790945740394 2.60674482558981 0.666666666666667 19.1 19 1 abnormal phrenic nerve morphology 2.70743948826902e-05 0.000514103490615968 2.60674482558981 0.666666666666667 19.1 19 1 abnormal pregnancy 2.70743948826902e-05 0.000514103490615968 2.60674482558981 0.666666666666667 19.1 19 1 small thoracic cage 2.70743948826902e-05 0.000514103490615968 2.60674482558981 0.666666666666667 19.1 19 1 absent incisors 0.000132508428338229 0.00196199235411514 2.60674482558981 0.666666666666667 19.1 19 1 delayed intramembranous bone ossification 0.000132508428338229 0.00196199235411514 2.60674482558981 0.666666666666667 19.1 19 1 abnormal pericyte morphology 0.000132508428338229 0.00196199235411514 2.60674482558981 0.666666666666667 19.1 19 1 abnormal placenta size 0.000132508428338229 0.00196199235411514 2.60674482558981 0.666666666666667 19.1 19 1 abnormal secondary palate development 0.000132508428338229 0.00196199235411514 2.60674482558981 0.666666666666667 19.1 19 1 synostosis 0.0033762364629256 0.0248106002999333 2.60674482558981 0.666666666666667 19.1 19 1 abnormal vomeronasal organ morphology 0.0033762364629256 0.0248106002999333 2.60674482558981 0.666666666666667 19.1 19 1 premature bone ossification 0.0033762364629256 0.0248106002999333 2.60674482558981 0.666666666666667 19.1 19 1 abnormal posterior eye segment morphology 0.0033762364629256 0.0248106002999333 2.60674482558981 0.666666666666667 19.1 19 1 positive geotaxis 0.0033762364629256 0.0248106002999333 2.60674482558981 0.666666666666667 19.1 19 1 increased cardiac muscle glycogen level 0.0033762364629256 0.0248106002999333 2.60674482558981 0.666666666666667 19.1 19 1 amyloid beta deposits 0.000439456000058667 0.00493520000065884 2.51364679610446 0.642857142857143 19.1 19 1 spina bifida occulta 0.000439456000058667 0.00493520000065884 2.51364679610446 0.642857142857143 19.1 19 1 multiple persisting craniopharyngeal ducts 0.000439456000058667 0.00493520000065884 2.51364679610446 0.642857142857143 19.1 19 1 abnormal basisphenoid bone morphology 1.24992962947035e-05 0.000258024892390664 2.48825642442664 0.636363636363636 19.1 19 1 impaired luteinization 0.00219357332317324 0.0174888257736969 2.48825642442664 0.636363636363636 19.1 19 1 abnormal pituitary gland development 0.00219357332317324 0.0174888257736969 2.48825642442664 0.636363636363636 19.1 19 1 abnormal spinal cord ventral horn morphology 0.00219357332317324 0.0174888257736969 2.48825642442664 0.636363636363636 19.1 19 1 abnormal palate development 0.00219357332317324 0.0174888257736969 2.48825642442664 0.636363636363636 19.1 19 1 abnormal palatal shelf elevation 0.00219357332317324 0.0174888257736969 2.48825642442664 0.636363636363636 19.1 19 1 aberrant origin of the right subclavian artery 0.00219357332317324 0.0174888257736969 2.48825642442664 0.636363636363636 19.1 19 1 abnormal cell differentiation 2.53478353882621e-09 1.46634280298377e-07 2.4795865414147 0.634146341463415 19.1 19 1 impaired branching involved in ureteric bud morphogenesis 1.17605420041622e-08 5.85086964707071e-07 2.46954772950614 0.631578947368421 19.1 19 1 short vibrissae 5.98113847861593e-05 0.00101556873485032 2.46954772950614 0.631578947368421 19.1 19 1 abnormal nasal septum morphology 5.98113847861593e-05 0.00101556873485032 2.46954772950614 0.631578947368421 19.1 19 1 vasculature congestion 0.00028865710898872 0.00359017279304721 2.44382327399045 0.625 19.1 19 1 dystonia 0.00028865710898872 0.00359017279304721 2.44382327399045 0.625 19.1 19 1 impaired behavioral response to addictive substance 0.00028865710898872 0.00359017279304721 2.44382327399045 0.625 19.1 19 1 failure of vascular branching 0.0112622243855859 0.0591653287415945 2.44382327399045 0.625 19.1 19 1 schistocytosis 0.0112622243855859 0.0591653287415945 2.44382327399045 0.625 19.1 19 1 pointed snout 0.0112622243855859 0.0591653287415945 2.44382327399045 0.625 19.1 19 1 clubfoot 0.0112622243855859 0.0591653287415945 2.44382327399045 0.625 19.1 19 1 enlarged pituitary gland 0.0112622243855859 0.0591653287415945 2.44382327399045 0.625 19.1 19 1 absent tympanic ring 0.0112622243855859 0.0591653287415945 2.44382327399045 0.625 19.1 19 1 decreased susceptibility to age related obesity 0.0112622243855859 0.0591653287415945 2.44382327399045 0.625 19.1 19 1 colon polyps 0.0112622243855859 0.0591653287415945 2.44382327399045 0.625 19.1 19 1 elevated level of mitotic sister chromatid exchange 0.0112622243855859 0.0591653287415945 2.44382327399045 0.625 19.1 19 1 abnormal hair follicle melanocyte morphology 0.0112622243855859 0.0591653287415945 2.44382327399045 0.625 19.1 19 1 abnormal canal of Schlemm morphology 0.0112622243855859 0.0591653287415945 2.44382327399045 0.625 19.1 19 1 abnormal somite size 0.0112622243855859 0.0591653287415945 2.44382327399045 0.625 19.1 19 1 abnormal vertebral body development 0.0112622243855859 0.0591653287415945 2.44382327399045 0.625 19.1 19 1 abnormal ilium morphology 0.0112622243855859 0.0591653287415945 2.44382327399045 0.625 19.1 19 1 craniofacial phenotype 0.0112622243855859 0.0591653287415945 2.44382327399045 0.625 19.1 19 1 abnormal meiotic spindle morphology 0.0112622243855859 0.0591653287415945 2.44382327399045 0.625 19.1 19 1 decreased hippocampus pyramidal cell number 0.0112622243855859 0.0591653287415945 2.44382327399045 0.625 19.1 19 1 abnormal cerebellum deep nucleus morphology 0.0112622243855859 0.0591653287415945 2.44382327399045 0.625 19.1 19 1 pulmonary artery hypoplasia 0.0112622243855859 0.0591653287415945 2.44382327399045 0.625 19.1 19 1 delayed suture closure 0.0112622243855859 0.0591653287415945 2.44382327399045 0.625 19.1 19 1 abnormal stomach position or orientation 0.0112622243855859 0.0591653287415945 2.44382327399045 0.625 19.1 19 1 absent ureteric bud 0.0112622243855859 0.0591653287415945 2.44382327399045 0.625 19.1 19 1 increased cornea thickness 0.0112622243855859 0.0591653287415945 2.44382327399045 0.625 19.1 19 1 increased brain apoptosis 0.0112622243855859 0.0591653287415945 2.44382327399045 0.625 19.1 19 1 malocclusion 3.67976507528476e-08 1.62007356190634e-06 2.43061341845536 0.621621621621622 19.1 19 1 decreased width of hypertrophic chondrocyte zone 3.67976507528476e-08 1.62007356190634e-06 2.43061341845536 0.621621621621622 19.1 19 1 preaxial polydactyly 7.88182203276818e-07 2.51359388545011e-05 2.39652346868741 0.612903225806452 19.1 19 1 abnormal metacarpal bone morphology 0.000187987758128128 0.00257641624431801 2.38951609012399 0.611111111111111 19.1 19 1 abnormal pulmonary artery morphology 2.59348426837458e-05 0.00049816927548894 2.38007136249504 0.608695652173913 19.1 19 1 absent corpus callosum 3.65220456164813e-06 9.36583386298941e-05 2.37399975187643 0.607142857142857 19.1 19 1 abnormal tooth development 5.21454648462972e-07 1.72949125073552e-05 2.36976802326346 0.606060606060606 19.1 19 1 abnormal postnatal subventricular zone morphology 0.000121745656438368 0.0018354080023663 2.34607034303083 0.6 19.1 19 1 abnormal incus morphology 0.000121745656438368 0.0018354080023663 2.34607034303083 0.6 19.1 19 1 retarded hair growth 0.00698823517708174 0.0437132060021873 2.34607034303083 0.6 19.1 19 1 absent maxillary shelf 0.00698823517708174 0.0437132060021873 2.34607034303083 0.6 19.1 19 1 increased cranium width 0.00698823517708174 0.0437132060021873 2.34607034303083 0.6 19.1 19 1 kidney hemorrhage 0.00698823517708174 0.0437132060021873 2.34607034303083 0.6 19.1 19 1 delayed dark adaptation 0.00698823517708174 0.0437132060021873 2.34607034303083 0.6 19.1 19 1 acrania 0.00698823517708174 0.0437132060021873 2.34607034303083 0.6 19.1 19 1 peritoneal inflammation 0.00698823517708174 0.0437132060021873 2.34607034303083 0.6 19.1 19 1 abnormal glial cell physiology 0.00698823517708174 0.0437132060021873 2.34607034303083 0.6 19.1 19 1 abnormal respiratory conducting tube morphology 0.00698823517708174 0.0437132060021873 2.34607034303083 0.6 19.1 19 1 protruding tongue 0.00698823517708174 0.0437132060021873 2.34607034303083 0.6 19.1 19 1 abnormal hippocampus neuron morphology 0.00698823517708174 0.0437132060021873 2.34607034303083 0.6 19.1 19 1 increased circulating fructosamine level 0.00698823517708174 0.0437132060021873 2.34607034303083 0.6 19.1 19 1 thick aortic valve cusps 0.00698823517708174 0.0437132060021873 2.34607034303083 0.6 19.1 19 1 decreased circulating lactate level 0.00698823517708174 0.0437132060021873 2.34607034303083 0.6 19.1 19 1 decreased chondrocyte number 0.00089987735763932 0.00890037744384815 2.34607034303083 0.6 19.1 19 1 abnormal cricoid cartilage morphology 0.00089987735763932 0.00890037744384815 2.34607034303083 0.6 19.1 19 1 arthritis 0.00089987735763932 0.00890037744384815 2.34607034303083 0.6 19.1 19 1 abnormal cerebral aqueduct morphology 0.00089987735763932 0.00890037744384815 2.34607034303083 0.6 19.1 19 1 abnormal branching involved in lung morphogenesis 0.00089987735763932 0.00890037744384815 2.34607034303083 0.6 19.1 19 1 decreased brown adipose tissue mass 0.00089987735763932 0.00890037744384815 2.34607034303083 0.6 19.1 19 1 cleft upper lip 7.85509050071912e-05 0.00127293404694064 2.31052382268188 0.590909090909091 19.1 19 1 small lung 2.06734902116339e-09 1.23916402172143e-07 2.30006896375572 0.588235294117647 19.1 19 1 abnormal glutamate-mediated receptor currents 0.000572950387654633 0.0062156812225275 2.30006896375572 0.588235294117647 19.1 19 1 increased brain size 0.000572950387654633 0.0062156812225275 2.30006896375572 0.588235294117647 19.1 19 1 abnormal outer ear morphology 7.14666270160819e-06 0.000161612031547731 2.2921376914669 0.586206896551724 19.1 19 1 short humerus 9.66173758750865e-08 3.9399298768734e-06 2.28884911515203 0.585365853658537 19.1 19 1 ocular hypertelorism 5.05516044695251e-05 0.000885543071253125 2.28090172239108 0.583333333333333 19.1 19 1 abnormal nursing 5.05516044695251e-05 0.000885543071253125 2.28090172239108 0.583333333333333 19.1 19 1 abnormal thymus involution 0.00434067360066467 0.031161401390053 2.28090172239108 0.583333333333333 19.1 19 1 abnormal alisphenoid bone morphology 0.00434067360066467 0.031161401390053 2.28090172239108 0.583333333333333 19.1 19 1 loss of dopaminergic neurons 0.00434067360066467 0.031161401390053 2.28090172239108 0.583333333333333 19.1 19 1 small intestinal inflammation 0.00434067360066467 0.031161401390053 2.28090172239108 0.583333333333333 19.1 19 1 bowed ulna 0.00434067360066467 0.031161401390053 2.28090172239108 0.583333333333333 19.1 19 1 persistent right dorsal aorta 0.00434067360066467 0.031161401390053 2.28090172239108 0.583333333333333 19.1 19 1 increased type II pneumocyte number 0.00434067360066467 0.031161401390053 2.28090172239108 0.583333333333333 19.1 19 1 abnormal postnatal growth/weight/body size 4.6260926074292e-06 0.000110118711588327 2.27039065454596 0.580645161290323 19.1 19 1 small cranium 4.6260926074292e-06 0.000110118711588327 2.27039065454596 0.580645161290323 19.1 19 1 short stride length 6.027779501358e-09 3.15665294939537e-07 2.26786799826313 0.58 19.1 19 1 abnormal metatarsal bone morphology 0.000364230271473334 0.00428379574605162 2.26375208538063 0.578947368421053 19.1 19 1 abnormal digestive system development 0.000364230271473334 0.00428379574605162 2.26375208538063 0.578947368421053 19.1 19 1 abnormal sternebra morphology 0.000364230271473334 0.00428379574605162 2.26375208538063 0.578947368421053 19.1 19 1 increased liver cholesterol level 0.000364230271473334 0.00428379574605162 2.26375208538063 0.578947368421053 19.1 19 1 eyelids open at birth 3.93211641016818e-09 2.1735865711763e-07 2.25583686829887 0.576923076923077 19.1 19 1 abnormal Mullerian duct morphology 3.24747133969749e-05 0.000605099996816293 2.25583686829887 0.576923076923077 19.1 19 1 abnormal long bone hypertrophic chondrocyte zone 1.73357668302267e-08 8.23613700398577e-07 2.23435270764841 0.571428571428571 19.1 19 1 abnormal stapes morphology 0.000231379319756442 0.00307783988178689 2.23435270764841 0.571428571428571 19.1 19 1 vascular ring 0.000231379319756442 0.00307783988178689 2.23435270764841 0.571428571428571 19.1 19 1 shortened head 2.0836036436316e-05 0.000411346354248698 2.23435270764841 0.571428571428571 19.1 19 1 abnormal placing response 0.00270186554006157 0.0209539281644423 2.23435270764841 0.571428571428571 19.1 19 1 absent olfactory bulb 0.00270186554006157 0.0209539281644423 2.23435270764841 0.571428571428571 19.1 19 1 vascular smooth muscle hypoplasia 0.00270186554006157 0.0209539281644423 2.23435270764841 0.571428571428571 19.1 19 1 decreased CNS synapse formation 0.00270186554006157 0.0209539281644423 2.23435270764841 0.571428571428571 19.1 19 1 increased pulmonary respiratory rate 0.00270186554006157 0.0209539281644423 2.23435270764841 0.571428571428571 19.1 19 1 sternebra fusion 0.00270186554006157 0.0209539281644423 2.23435270764841 0.571428571428571 19.1 19 1 increased stomach tumor incidence 0.00270186554006157 0.0209539281644423 2.23435270764841 0.571428571428571 19.1 19 1 abnormal forebrain development 1.02229339681687e-11 1.03794074472733e-09 2.22659453852463 0.569444444444444 19.1 19 1 abnormal astrocyte morphology 1.17647884518732e-07 4.64522401175153e-06 2.2216575218095 0.568181818181818 19.1 19 1 abnormal brain vasculature morphology 1.33569381936751e-05 0.000274589948403031 2.21573310175134 0.566666666666667 19.1 19 1 failure of tooth eruption 0.00168573196304723 0.0145550954682029 2.1994409465914 0.5625 19.1 19 1 decreased cochlear coiling 0.00168573196304723 0.0145550954682029 2.1994409465914 0.5625 19.1 19 1 decreased liver cholesterol level 0.00168573196304723 0.0145550954682029 2.1994409465914 0.5625 19.1 19 1 dilated respiratory conducting tubes 0.00168573196304723 0.0145550954682029 2.1994409465914 0.5625 19.1 19 1 decreased midbrain size 0.00168573196304723 0.0145550954682029 2.1994409465914 0.5625 19.1 19 1 decreased fibroblast apoptosis 0.00168573196304723 0.0145550954682029 2.1994409465914 0.5625 19.1 19 1 impaired limb coordination 1.32045435403963e-08 6.50421822905659e-07 2.17228735465818 0.555555555555556 19.1 19 1 lowered ear position 0.00105415367456276 0.00995145072286481 2.17228735465818 0.555555555555556 19.1 19 1 abnormal heart shape 0.00105415367456276 0.00995145072286481 2.17228735465818 0.555555555555556 19.1 19 1 delayed kidney development 0.00105415367456276 0.00995145072286481 2.17228735465818 0.555555555555556 19.1 19 1 abnormal glycogen homeostasis 0.00105415367456276 0.00995145072286481 2.17228735465818 0.555555555555556 19.1 19 1 decreased lactate dehydrogenase level 0.00105415367456276 0.00995145072286481 2.17228735465818 0.555555555555556 19.1 19 1 increased gastrointestinal tumor incidence 0.00105415367456276 0.00995145072286481 2.17228735465818 0.555555555555556 19.1 19 1 abnormal metanephric mesenchyme morphology 0.00105415367456276 0.00995145072286481 2.17228735465818 0.555555555555556 19.1 19 1 distorted hair follicle pattern 0.0211197092889113 0.0938326060520286 2.17228735465818 0.555555555555556 19.1 19 1 wavy vibrissae 0.0211197092889113 0.0938326060520286 2.17228735465818 0.555555555555556 19.1 19 1 abnormal kindling response 0.0211197092889113 0.0938326060520286 2.17228735465818 0.555555555555556 19.1 19 1 abnormal thymus physiology 0.0211197092889113 0.0938326060520286 2.17228735465818 0.555555555555556 19.1 19 1 abnormal bony labyrinth 0.0211197092889113 0.0938326060520286 2.17228735465818 0.555555555555556 19.1 19 1 small scapula 0.0211197092889113 0.0938326060520286 2.17228735465818 0.555555555555556 19.1 19 1 decreased cochlear hair cell number 0.0211197092889113 0.0938326060520286 2.17228735465818 0.555555555555556 19.1 19 1 increased neuronal precursor cell number 0.0211197092889113 0.0938326060520286 2.17228735465818 0.555555555555556 19.1 19 1 abnormal inguinal fat pad morphology 0.0211197092889113 0.0938326060520286 2.17228735465818 0.555555555555556 19.1 19 1 abnormal retinal development 0.0211197092889113 0.0938326060520286 2.17228735465818 0.555555555555556 19.1 19 1 shortened ST segment 0.0211197092889113 0.0938326060520286 2.17228735465818 0.555555555555556 19.1 19 1 abnormal ureteric bud invasion 0.0211197092889113 0.0938326060520286 2.17228735465818 0.555555555555556 19.1 19 1 symmetric azygos veins 0.0211197092889113 0.0938326060520286 2.17228735465818 0.555555555555556 19.1 19 1 decreased fatty acid oxidation 0.0211197092889113 0.0938326060520286 2.17228735465818 0.555555555555556 19.1 19 1 blood in lymph vessels 3.7684496417495e-05 0.000691809482203091 2.15730606255708 0.551724137931034 19.1 19 1 double outlet right ventricle 2.37320734490528e-15 4.54104097727068e-13 2.15604595387568 0.551401869158878 19.1 19 1 increased mammary adenocarcinoma incidence 0.00066060035651607 0.00699252505035627 2.15056448111159 0.55 19.1 19 1 abnormal response to tactile stimuli 0.00066060035651607 0.00699252505035627 2.15056448111159 0.55 19.1 19 1 abnormal nose morphology 2.39586792626878e-05 0.000467429134634791 2.14425784040452 0.548387096774194 19.1 19 1 short snout 4.19312066743407e-15 7.45027690017304e-13 2.13608256541387 0.546296296296296 19.1 19 1 abnormal middle ear ossicle morphology 1.52386798298677e-05 0.000310706689154064 2.13279122093712 0.545454545454545 19.1 19 1 aphakia 0.000414773417455543 0.00474367299273868 2.13279122093712 0.545454545454545 19.1 19 1 abnormal cerebral cortex pyramidal cell morphology 0.000414773417455543 0.00474367299273868 2.13279122093712 0.545454545454545 19.1 19 1 increased mammary gland tumor incidence 0.000414773417455543 0.00474367299273868 2.13279122093712 0.545454545454545 19.1 19 1 abnormal ear position 0.0127418294017719 0.0647503588088 2.13279122093712 0.545454545454545 19.1 19 1 abnormal thrombopoiesis 0.0127418294017719 0.0647503588088 2.13279122093712 0.545454545454545 19.1 19 1 abnormal sebaceous gland morphology 0.0127418294017719 0.0647503588088 2.13279122093712 0.545454545454545 19.1 19 1 abnormal proximal-distal axis patterning 0.0127418294017719 0.0647503588088 2.13279122093712 0.545454545454545 19.1 19 1 abnormal fear/anxiety-related behavior 0.0127418294017719 0.0647503588088 2.13279122093712 0.545454545454545 19.1 19 1 abnormal bronchiole morphology 0.0127418294017719 0.0647503588088 2.13279122093712 0.545454545454545 19.1 19 1 fatigue 0.0127418294017719 0.0647503588088 2.13279122093712 0.545454545454545 19.1 19 1 patent ductus arteriosus 0.0127418294017719 0.0647503588088 2.13279122093712 0.545454545454545 19.1 19 1 fused joints 0.0127418294017719 0.0647503588088 2.13279122093712 0.545454545454545 19.1 19 1 abnormal crista ampullaris neuroepithelium morphology 0.0127418294017719 0.0647503588088 2.13279122093712 0.545454545454545 19.1 19 1 increased circulating triiodothyronine level 0.0127418294017719 0.0647503588088 2.13279122093712 0.545454545454545 19.1 19 1 palatal shelf hypoplasia 0.0127418294017719 0.0647503588088 2.13279122093712 0.545454545454545 19.1 19 1 abnormal phrenic nerve innervation pattern to diaphragm 0.0127418294017719 0.0647503588088 2.13279122093712 0.545454545454545 19.1 19 1 reduced sympathetic cervical ganglion size 0.0127418294017719 0.0647503588088 2.13279122093712 0.545454545454545 19.1 19 1 abnormal artery morphology 9.69663002570946e-06 0.000207934199904761 2.12263507226599 0.542857142857143 19.1 19 1 decreased triglyceride level 9.69663002570946e-06 0.000207934199904761 2.12263507226599 0.542857142857143 19.1 19 1 abnormal hippocampus pyramidal cell morphology 9.69663002570946e-06 0.000207934199904761 2.12263507226599 0.542857142857143 19.1 19 1 overriding aortic valve 2.41259657244064e-07 8.8908651465868e-06 2.11798017079172 0.541666666666667 19.1 19 1 blindness 0.00026087927332366 0.00339757692352149 2.11798017079172 0.541666666666667 19.1 19 1 abnormal truncus arteriosus septation 0.00026087927332366 0.00339757692352149 2.11798017079172 0.541666666666667 19.1 19 1 no spontaneous movement 0.000164342662035659 0.00234289434457354 2.10544774374562 0.538461538461538 19.1 19 1 increased susceptibility to otitis media 0.000164342662035659 0.00234289434457354 2.10544774374562 0.538461538461538 19.1 19 1 increased foot pad pigmentation 0.00776088936470356 0.0461295395333336 2.10544774374562 0.538461538461538 19.1 19 1 increased pituitary adenoma incidence 0.00776088936470356 0.0461295395333336 2.10544774374562 0.538461538461538 19.1 19 1 anal atresia 0.00776088936470356 0.0461295395333336 2.10544774374562 0.538461538461538 19.1 19 1 absent lateral semicircular canal 0.00776088936470356 0.0461295395333336 2.10544774374562 0.538461538461538 19.1 19 1 tracheoesophageal fistula 0.00776088936470356 0.0461295395333336 2.10544774374562 0.538461538461538 19.1 19 1 increased circulating thyroid-stimulating hormone level 0.00776088936470356 0.0461295395333336 2.10544774374562 0.538461538461538 19.1 19 1 decreased luteinizing hormone level 0.00776088936470356 0.0461295395333336 2.10544774374562 0.538461538461538 19.1 19 1 increased circulating thyroxine level 0.00776088936470356 0.0461295395333336 2.10544774374562 0.538461538461538 19.1 19 1 absent hypoglossal nerve 0.00776088936470356 0.0461295395333336 2.10544774374562 0.538461538461538 19.1 19 1 abnormal cranium morphology 1.41601099597129e-17 3.70771300260904e-15 2.10095851614701 0.537313432835821 19.1 19 1 abnormal neuronal precursor proliferation 6.33078572157875e-08 2.65335126042526e-06 2.09987777616957 0.537037037037037 19.1 19 1 abnormal limb morphology 2.78683158817837e-10 2.10067987139203e-08 2.08539586047185 0.533333333333333 19.1 19 1 abnormal cellular respiration 6.54874201018605e-05 0.00109317796025797 2.08539586047185 0.533333333333333 19.1 19 1 interdigital webbing 0.00476128060568698 0.0331282006366315 2.08539586047185 0.533333333333333 19.1 19 1 decreased aggression towards males 0.00476128060568698 0.0331282006366315 2.08539586047185 0.533333333333333 19.1 19 1 immune system phenotype 0.00476128060568698 0.0331282006366315 2.08539586047185 0.533333333333333 19.1 19 1 abnormal aorta wall morphology 0.00476128060568698 0.0331282006366315 2.08539586047185 0.533333333333333 19.1 19 1 increased respiratory quotient 6.49306236756383e-07 2.12519639990987e-05 2.07984959488549 0.531914893617021 19.1 19 1 scoliosis 4.14135832816828e-05 0.000743799916340692 2.07724978289188 0.53125 19.1 19 1 pericardial edema 2.80096899502104e-09 1.60170353450916e-07 2.07006206738014 0.529411764705882 19.1 19 1 abnormal vagus nerve morphology 0.00293761123536391 0.0221185430082123 2.07006206738014 0.529411764705882 19.1 19 1 increased incidence of corneal inflammation 0.00293761123536391 0.0221185430082123 2.07006206738014 0.529411764705882 19.1 19 1 abnormal cranial suture morphology 0.00293761123536391 0.0221185430082123 2.07006206738014 0.529411764705882 19.1 19 1 abnormal embryonic-extraembryonic boundary morphology 0.00293761123536391 0.0221185430082123 2.07006206738014 0.529411764705882 19.1 19 1 coloboma 0.00293761123536391 0.0221185430082123 2.07006206738014 0.529411764705882 19.1 19 1 decreased body fat mass 0.00293761123536391 0.0221185430082123 2.07006206738014 0.529411764705882 19.1 19 1 domed cranium 1.79490081033276e-09 1.08897945504945e-07 2.06677625457478 0.528571428571429 19.1 19 1 atrioventricular septal defect 1.68849053981075e-07 6.41239727905229e-06 2.06572231461834 0.528301886792453 19.1 19 1 narrow eye opening 1.66127906660586e-05 0.000334609852484378 2.06367298692527 0.527777777777778 19.1 19 1 irregular coat pigmentation 0.00182073523355102 0.0150467737324192 2.05795644125511 0.526315789473684 19.1 19 1 abnormal stationary movement 0.00182073523355102 0.0150467737324192 2.05795644125511 0.526315789473684 19.1 19 1 abnormal optic vesicle formation 0.00182073523355102 0.0150467737324192 2.05795644125511 0.526315789473684 19.1 19 1 gliosis 1.79916549147948e-08 8.44419652840603e-07 2.04815664867771 0.523809523809524 19.1 19 1 abnormal cartilage morphology 4.2478589268982e-06 0.00010634243740648 2.04815664867771 0.523809523809524 19.1 19 1 abnormal tumor vascularization 0.00113274349695166 0.0104942251347011 2.04815664867771 0.523809523809524 19.1 19 1 abnormal vitelline vasculature morphology 3.95736043230157e-14 6.35092520990332e-12 2.0400611678529 0.521739130434783 19.1 19 1 failure to gastrulate 1.71726108572954e-06 4.93798539989963e-05 2.0400611678529 0.521739130434783 19.1 19 1 abnormal innervation pattern to muscle 0.000706942469922313 0.00728165380510043 2.0400611678529 0.521739130434783 19.1 19 1 abnormal cranial nerve morphology 0.000706942469922313 0.00728165380510043 2.0400611678529 0.521739130434783 19.1 19 1 abnormal nasal cavity morphology 0.000706942469922313 0.00728165380510043 2.0400611678529 0.521739130434783 19.1 19 1 abnormal chondrocyte physiology 0.000706942469922313 0.00728165380510043 2.0400611678529 0.521739130434783 19.1 19 1 abnormal basicranium morphology 0.000706942469922313 0.00728165380510043 2.0400611678529 0.521739130434783 19.1 19 1 microcephaly 4.7079950241144e-09 2.54589948314882e-07 2.04006116785289 0.521739130434783 19.1 19 1 vertebral transformation 1.09283512753064e-06 3.25560165237421e-05 2.03651939499204 0.520833333333333 19.1 19 1 delayed bone ossification 1.23408844649394e-09 7.87126925808635e-08 2.03326096396005 0.52 19.1 19 1 abnormal egg cylinder morphology 0.000442383572258227 0.00495688799996549 2.03326096396005 0.52 19.1 19 1 abnormal chondrocyte morphology 2.82508804343693e-07 1.01908277447634e-05 2.02746819768096 0.518518518518518 19.1 19 1 abnormal trigeminal nerve morphology 0.000277468517065149 0.00351248313587562 2.02746819768096 0.518518518518518 19.1 19 1 abnormal trigeminal ganglion morphology 0.000277468517065149 0.00351248313587562 2.02746819768096 0.518518518518518 19.1 19 1 increased brain weight 0.000277468517065149 0.00351248313587562 2.02746819768096 0.518518518518518 19.1 19 1 abnormal eye development 1.80127854026023e-07 6.78890964984442e-06 2.02488214130637 0.517857142857143 19.1 19 1 abnormal lung development 1.32907306506992e-10 1.08395713093817e-08 2.02406068810503 0.517647058823529 19.1 19 1 absent long term depression 0.000174380188074236 0.00245068202166475 2.02247443364727 0.517241379310345 19.1 19 1 abnormal eyelid morphology 0.000109784743663645 0.0016962083842442 2.01812502626308 0.516129032258065 19.1 19 1 abnormal aorta morphology 6.92244181992361e-05 0.0011403691408649 2.01430281977394 0.515151515151515 19.1 19 1 belly spot 6.92244181992361e-05 0.0011403691408649 2.01430281977394 0.515151515151515 19.1 19 1 ventricular septal defect 7.79212294100738e-16 1.84599103007199e-13 2.01256034328625 0.514705882352941 19.1 19 1 abnormal midbrain development 4.3709366630091e-05 0.000779405372705027 2.01091743688357 0.514285714285714 19.1 19 1 abnormal breathing pattern 2.76327685324508e-05 0.000522711115775447 2.00789804133269 0.513513513513513 19.1 19 1 increased rib number 1.30280604378183e-09 8.10182508476824e-08 2.00518832737678 0.512820512820513 19.1 19 1 abnormal left-right axis patterning 7.02551405166021e-06 0.000160329965169769 2.00052509870846 0.511627906976744 19.1 19 1 delayed endochondral bone ossification 7.02551405166021e-06 0.000160329965169769 2.00052509870846 0.511627906976744 19.1 19 1 pulmonary hypoplasia 2.83164875422326e-06 7.57389922164554e-05 1.99665561109007 0.51063829787234 19.1 19 1 absent kidney 1.79963237748804e-06 5.11609775885885e-05 1.99495777468608 0.510204081632653 19.1 19 1 failure of chorioallantoic fusion 1.14446873501882e-06 3.38912616471348e-05 1.99339310192162 0.509803921568627 19.1 19 1 abnormal learning/memory/conditioning 4.63646271278248e-07 1.57989054767759e-05 1.99060513954131 0.509090909090909 19.1 19 1 internal hemorrhage 3.11668210892484e-08 1.42252233870652e-06 1.98423859858329 0.507462686567164 19.1 19 1 anophthalmia 2.27157907712868e-10 1.79382633471669e-08 1.9770255699698 0.50561797752809 19.1 19 1 hydroencephaly 6.94159117193449e-13 8.22248001913668e-11 1.97205912892447 0.504347826086956 19.1 19 1 abnormal nasal bone morphology 0.000720424482480795 0.00732947198433937 1.95505861919236 0.5 19.1 19 1 ventricular hypoplasia 0.000720424482480795 0.00732947198433937 1.95505861919236 0.5 19.1 19 1 abnormal ureter morphology 0.000720424482480795 0.00732947198433937 1.95505861919236 0.5 19.1 19 1 heart inflammation 0.000720424482480795 0.00732947198433937 1.95505861919236 0.5 19.1 19 1 abnormal ocular fundus morphology 0.000720424482480795 0.00732947198433937 1.95505861919236 0.5 19.1 19 1 abnormal incisor morphology 3.03103525663071e-07 1.07710002869555e-05 1.95505861919236 0.5 19.1 19 1 short mandible 7.4716468853048e-07 2.41373008145399e-05 1.95505861919236 0.5 19.1 19 1 perinatal lethality 2.82896641356012e-05 0.000533110148009909 1.95505861919236 0.5 19.1 19 1 persistence of hyaloid vascular system 4.47294267308012e-05 0.000791917786426106 1.95505861919236 0.5 19.1 19 1 renal hypoplasia 7.08059425941232e-05 0.00115117504707766 1.95505861919236 0.5 19.1 19 1 short radius 7.08059425941232e-05 0.00115117504707766 1.95505861919236 0.5 19.1 19 1 abnormal retinal blood vessel morphology 7.08059425941232e-05 0.00115117504707766 1.95505861919236 0.5 19.1 19 1 short maxilla 0.000112231734307778 0.00171800885594215 1.95505861919236 0.5 19.1 19 1 abnormal vertebral body morphology 0.000178155904045606 0.00247576989560584 1.95505861919236 0.5 19.1 19 1 abnormal auditory brainstem response waveform shape 0.000178155904045606 0.00247576989560584 1.95505861919236 0.5 19.1 19 1 abnormal lactation 0.000283272956046611 0.00354983112426168 1.95505861919236 0.5 19.1 19 1 abnormal somite shape 0.000451261514154379 0.0050000579797729 1.95505861919236 0.5 19.1 19 1 abnormal hormone level 0.000451261514154379 0.0050000579797729 1.95505861919236 0.5 19.1 19 1 abnormal lung saccule morphology 0.00115300566652097 0.0106620877155052 1.95505861919236 0.5 19.1 19 1 abnormal tail movements 0.00185071357644778 0.0150939344964389 1.95505861919236 0.5 19.1 19 1 abnormal chorion morphology 0.00185071357644778 0.0150939344964389 1.95505861919236 0.5 19.1 19 1 abnormal tracheal cartilage morphology 0.00185071357644778 0.0150939344964389 1.95505861919236 0.5 19.1 19 1 abnormal blood-brain barrier function 0.00185071357644778 0.0150939344964389 1.95505861919236 0.5 19.1 19 1 failure of palatal shelf elevation 0.00185071357644778 0.0150939344964389 1.95505861919236 0.5 19.1 19 1 increased adenoma incidence 0.00185071357644778 0.0150939344964389 1.95505861919236 0.5 19.1 19 1 increased bone volume 0.00185071357644778 0.0150939344964389 1.95505861919236 0.5 19.1 19 1 embryonic lethality before implantation, incomplete penetrance 0.00185071357644778 0.0150939344964389 1.95505861919236 0.5 19.1 19 1 anencephaly 0.00298087011058597 0.0222766959710607 1.95505861919236 0.5 19.1 19 1 abnormal dopamine level 0.00298087011058597 0.0222766959710607 1.95505861919236 0.5 19.1 19 1 abnormal hyoid bone morphology 0.00298087011058597 0.0222766959710607 1.95505861919236 0.5 19.1 19 1 spleen atrophy 0.00298087011058597 0.0222766959710607 1.95505861919236 0.5 19.1 19 1 abnormal mitral valve morphology 0.00482106879616506 0.0331282006366315 1.95505861919236 0.5 19.1 19 1 right pulmonary isomerism 0.00482106879616506 0.0331282006366315 1.95505861919236 0.5 19.1 19 1 eye inflammation 0.00482106879616506 0.0331282006366315 1.95505861919236 0.5 19.1 19 1 abnormal thyroid cartilage morphology 0.00482106879616506 0.0331282006366315 1.95505861919236 0.5 19.1 19 1 decreased activity of thyroid 0.00482106879616506 0.0331282006366315 1.95505861919236 0.5 19.1 19 1 abnormal eye anterior chamber morphology 0.00482106879616506 0.0331282006366315 1.95505861919236 0.5 19.1 19 1 darkened coat color 0.00482106879616506 0.0331282006366315 1.95505861919236 0.5 19.1 19 1 abnormal aerobic respiration 0.00482106879616506 0.0331282006366315 1.95505861919236 0.5 19.1 19 1 absent mandible 0.00783682924832674 0.0462493778296863 1.95505861919236 0.5 19.1 19 1 disorganized retinal layers 0.00783682924832674 0.0462493778296863 1.95505861919236 0.5 19.1 19 1 abnormal epicardium morphology 0.00783682924832674 0.0462493778296863 1.95505861919236 0.5 19.1 19 1 abnormal pulmonary elastic fiber morphology 0.00783682924832674 0.0462493778296863 1.95505861919236 0.5 19.1 19 1 blepharitis 0.00783682924832674 0.0462493778296863 1.95505861919236 0.5 19.1 19 1 abnormal pulmonary alveolus wall morphology 0.00783682924832674 0.0462493778296863 1.95505861919236 0.5 19.1 19 1 abnormal fluid regulation 0.0128199131893456 0.0648161261351568 1.95505861919236 0.5 19.1 19 1 increased hemangioma incidence 0.0128199131893456 0.0648161261351568 1.95505861919236 0.5 19.1 19 1 abnormal voluntary movement 0.0128199131893456 0.0648161261351568 1.95505861919236 0.5 19.1 19 1 abnormal pancreas development 0.0128199131893456 0.0648161261351568 1.95505861919236 0.5 19.1 19 1 abnormal squamosal bone morphology 0.0128199131893456 0.0648161261351568 1.95505861919236 0.5 19.1 19 1 mesocardia 0.0211429852028792 0.0938326060520286 1.95505861919236 0.5 19.1 19 1 abnormal mating frequency 0.0211429852028792 0.0938326060520286 1.95505861919236 0.5 19.1 19 1 impaired embryo implantation 0.0211429852028792 0.0938326060520286 1.95505861919236 0.5 19.1 19 1 myocarditis 0.0211429852028792 0.0938326060520286 1.95505861919236 0.5 19.1 19 1 abnormal embryonic growth/weight/body size 0.0211429852028792 0.0938326060520286 1.95505861919236 0.5 19.1 19 1 abnormal corticospinal tract morphology 0.0211429852028792 0.0938326060520286 1.95505861919236 0.5 19.1 19 1 abnormal AMPA-mediated synaptic currents 0.0211429852028792 0.0938326060520286 1.95505861919236 0.5 19.1 19 1 decreased synaptic depression 0.0211429852028792 0.0938326060520286 1.95505861919236 0.5 19.1 19 1 absent ovary 0.0211429852028792 0.0938326060520286 1.95505861919236 0.5 19.1 19 1 increased osteosarcoma incidence 0.0211429852028792 0.0938326060520286 1.95505861919236 0.5 19.1 19 1 abnormal defecation 0.0211429852028792 0.0938326060520286 1.95505861919236 0.5 19.1 19 1 stria vascularis degeneration 0.0211429852028792 0.0938326060520286 1.95505861919236 0.5 19.1 19 1 decreased cochlear nerve compound action potential 0.0211429852028792 0.0938326060520286 1.95505861919236 0.5 19.1 19 1 hematuria 0.0211429852028792 0.0938326060520286 1.95505861919236 0.5 19.1 19 1 abnormal fatty acid level 0.0211429852028792 0.0938326060520286 1.95505861919236 0.5 19.1 19 1 abnormal aorta elastic tissue morphology 0.0211429852028792 0.0938326060520286 1.95505861919236 0.5 19.1 19 1 decreased red blood cell distribution width 0.0211429852028792 0.0938326060520286 1.95505861919236 0.5 19.1 19 1 abnormal pulmonary valve cusp morphology 0.0211429852028792 0.0938326060520286 1.95505861919236 0.5 19.1 19 1 abnormal lateral semicircular canal morphology 0.0352511834007409 0.137544350610189 1.95505861919236 0.5 19.1 19 1 absent palatine bone horizontal plate 0.0352511834007409 0.137544350610189 1.95505861919236 0.5 19.1 19 1 abnormal grooming behavior 0.0352511834007409 0.137544350610189 1.95505861919236 0.5 19.1 19 1 abnormal pituitary secretion 0.0352511834007409 0.137544350610189 1.95505861919236 0.5 19.1 19 1 abnormal respiratory mechanics 0.0352511834007409 0.137544350610189 1.95505861919236 0.5 19.1 19 1 aneurysm 0.0352511834007409 0.137544350610189 1.95505861919236 0.5 19.1 19 1 lymphedema 0.0352511834007409 0.137544350610189 1.95505861919236 0.5 19.1 19 1 absent CD4-positive, alpha beta T cells 0.0352511834007409 0.137544350610189 1.95505861919236 0.5 19.1 19 1 increased atrioventricular cushion size 0.0352511834007409 0.137544350610189 1.95505861919236 0.5 19.1 19 1 increased heart rate variability 0.0352511834007409 0.137544350610189 1.95505861919236 0.5 19.1 19 1 abnormal gas homeostasis 0.0352511834007409 0.137544350610189 1.95505861919236 0.5 19.1 19 1 abnormal plasma membrane morphology 0.0352511834007409 0.137544350610189 1.95505861919236 0.5 19.1 19 1 abnormal placental transport 0.0352511834007409 0.137544350610189 1.95505861919236 0.5 19.1 19 1 absent coat pigmentation 0.0352511834007409 0.137544350610189 1.95505861919236 0.5 19.1 19 1 increased susceptibility to atherosclerosis 0.0352511834007409 0.137544350610189 1.95505861919236 0.5 19.1 19 1 vascular smooth muscle hyperplasia 0.0352511834007409 0.137544350610189 1.95505861919236 0.5 19.1 19 1 absent inguinal lymph nodes 0.0352511834007409 0.137544350610189 1.95505861919236 0.5 19.1 19 1 abnormal heart and great artery attachment 0.0352511834007409 0.137544350610189 1.95505861919236 0.5 19.1 19 1 abnormal left subclavian artery morphology 0.0352511834007409 0.137544350610189 1.95505861919236 0.5 19.1 19 1 thick aortic valve 0.0352511834007409 0.137544350610189 1.95505861919236 0.5 19.1 19 1 fusion of atlas and odontoid process 0.0352511834007409 0.137544350610189 1.95505861919236 0.5 19.1 19 1 cleft palate 7.87971446433934e-14 1.15298763117907e-11 1.94013450759547 0.49618320610687 19.1 19 1 abnormal nervous system morphology 8.45892909178876e-09 4.33847136408754e-07 1.93031104173423 0.493670886075949 19.1 19 1 perimembraneous ventricular septal defect 7.95170809360529e-08 3.29664564714053e-06 1.92672443630551 0.492753623188406 19.1 19 1 abnormal long bone morphology 4.80307910292083e-07 1.62553187326742e-05 1.92300847789412 0.491803278688525 19.1 19 1 decreased birth body size 6.7932711185105e-12 7.04094246137287e-10 1.92075934517144 0.491228070175439 19.1 19 1 abnormal head morphology 1.85895072840054e-06 5.1666368010015e-05 1.91951209884341 0.490909090909091 19.1 19 1 abnormal contextual conditioning behavior 1.85895072840054e-06 5.1666368010015e-05 1.91951209884341 0.490909090909091 19.1 19 1 decreased circulating total protein level 1.85895072840054e-06 5.1666368010015e-05 1.91951209884341 0.490909090909091 19.1 19 1 abnormal axon morphology 2.58033968460061e-11 2.42211130771472e-09 1.91885382994806 0.490740740740741 19.1 19 1 impaired balance 9.80945598722913e-11 8.27153280279067e-09 1.9167241364631 0.490196078431373 19.1 19 1 abnormal cued conditioning behavior 4.59474458923172e-06 0.000110118711588327 1.9167241364631 0.490196078431373 19.1 19 1 abnormal innervation 1.13860764671867e-05 0.000237011424369262 1.91346162729465 0.48936170212766 19.1 19 1 abnormal eye morphology 5.15096219029678e-14 8.00813653022703e-12 1.91286310942562 0.489208633093525 19.1 19 1 short ulna 4.46803088467554e-05 0.000791917786426106 1.90737426262669 0.48780487804878 19.1 19 1 increased hepatocyte apoptosis 7.06082153447733e-05 0.00115117504707766 1.90492891100794 0.487179487179487 19.1 19 1 abnormal long bone metaphysis morphology 0.00011170684433676 0.00171800885594215 1.90221919705202 0.486486486486487 19.1 19 1 ovary cysts 0.000176947303781148 0.00247278886604273 1.89919980150115 0.485714285714286 19.1 19 1 decreased glycogen level 0.000176947303781148 0.00247278886604273 1.89919980150115 0.485714285714286 19.1 19 1 decreased circulating alanine transaminase level 1.94786113367038e-07 7.28617228572193e-06 1.89755689509846 0.485294117647059 19.1 19 1 single kidney 0.000280679655430424 0.00352621536809687 1.89581441861077 0.484848484848485 19.1 19 1 increased osteoblast cell number 0.000280679655430424 0.00352621536809687 1.89581441861077 0.484848484848485 19.1 19 1 myeloid hyperplasia 0.000280679655430424 0.00352621536809687 1.89581441861077 0.484848484848485 19.1 19 1 abnormal object recognition memory 0.00044591815515564 0.00497603880709478 1.89199221212164 0.483870967741935 19.1 19 1 abnormal embryonic neuroepithelium morphology 1.84388357197195e-06 5.1666368010015e-05 1.88764280473745 0.482758620689655 19.1 19 1 short sternum 0.000709684085162515 0.00729478992496593 1.88764280473745 0.482758620689655 19.1 19 1 short limbs 5.3928020018282e-09 2.88485913538659e-07 1.88764280473745 0.482758620689655 19.1 19 1 preweaning lethality, incomplete penetrance 1.28017057066882e-36 1.59221214726934e-33 1.88335720284056 0.481662591687042 19.1 19 1 abnormal maxilla morphology 4.54458515677532e-06 0.000110118711588327 1.88264904070375 0.481481481481481 19.1 19 1 abnormal cell adhesion 4.54458515677532e-06 0.000110118711588327 1.88264904070375 0.481481481481481 19.1 19 1 abnormal heart valve morphology 0.00113174073608103 0.0104942251347011 1.88264904070375 0.481481481481481 19.1 19 1 abnormal brain commissure morphology 0.00113174073608103 0.0104942251347011 1.88264904070375 0.481481481481481 19.1 19 1 abnormal skin appearance 0.00113174073608103 0.0104942251347011 1.88264904070375 0.481481481481481 19.1 19 1 thick interventricular septum 0.00113174073608103 0.0104942251347011 1.88264904070375 0.481481481481481 19.1 19 1 decreased kidney weight 7.14018652401183e-06 0.000161612031547731 1.87986405691573 0.480769230769231 19.1 19 1 abnormal skeleton morphology 3.94633609145392e-11 3.6357448249969e-09 1.87005607053182 0.478260869565217 19.1 19 1 abnormal locomotor behavior 3.4040576734872e-09 1.92445305972714e-07 1.87005607053182 0.478260869565217 19.1 19 1 abnormal postnatal growth 0.00289917042409611 0.0220878604286036 1.87005607053182 0.478260869565217 19.1 19 1 conjunctivitis 0.00289917042409611 0.0220878604286036 1.87005607053182 0.478260869565217 19.1 19 1 abnormal sacral vertebrae morphology 0.00289917042409611 0.0220878604286036 1.87005607053182 0.478260869565217 19.1 19 1 abnormal Wolffian duct morphology 0.00289917042409611 0.0220878604286036 1.87005607053182 0.478260869565217 19.1 19 1 abnormal corneal stroma morphology 0.00289917042409611 0.0220878604286036 1.87005607053182 0.478260869565217 19.1 19 1 abnormal scapula morphology 0.00466098521388988 0.0327519794337601 1.86196058970701 0.476190476190476 19.1 19 1 abnormal embryonic/fetal subventricular zone morphology 0.00466098521388988 0.0327519794337601 1.86196058970701 0.476190476190476 19.1 19 1 complete atrioventricular septal defect 0.00466098521388988 0.0327519794337601 1.86196058970701 0.476190476190476 19.1 19 1 abnormal retinal pigment epithelium morphology 4.91995994772284e-08 2.11006902930355e-06 1.85730568823274 0.475 19.1 19 1 abnormal motor coordination/ balance 1.37063200240964e-09 8.41838791603451e-08 1.85631828488971 0.474747474747475 19.1 19 1 abnormal craniofacial bone morphology 4.43364349706033e-06 0.000108657026590518 1.8521607971296 0.473684210526316 19.1 19 1 decreased brain weight 4.43364349706033e-06 0.000108657026590518 1.8521607971296 0.473684210526316 19.1 19 1 abnormal facial morphology 4.43364349706033e-06 0.000108657026590518 1.8521607971296 0.473684210526316 19.1 19 1 kyphoscoliosis 0.00752136900251771 0.0451918004680261 1.8521607971296 0.473684210526316 19.1 19 1 abnormal triglyceride level 0.00752136900251771 0.0451918004680261 1.8521607971296 0.473684210526316 19.1 19 1 stereotypic behavior 0.00752136900251771 0.0451918004680261 1.8521607971296 0.473684210526316 19.1 19 1 increased susceptibility to ischemic brain injury 0.00752136900251771 0.0451918004680261 1.8521607971296 0.473684210526316 19.1 19 1 osteoarthritis 0.00752136900251771 0.0451918004680261 1.8521607971296 0.473684210526316 19.1 19 1 eyelids fail to open 0.00752136900251771 0.0451918004680261 1.8521607971296 0.473684210526316 19.1 19 1 increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 0.00752136900251771 0.0451918004680261 1.8521607971296 0.473684210526316 19.1 19 1 right-sided stomach 0.00752136900251771 0.0451918004680261 1.8521607971296 0.473684210526316 19.1 19 1 abnormal embryo turning 6.95239533393894e-06 0.00016013040178864 1.8484190581455 0.472727272727273 19.1 19 1 abnormal neuromuscular synapse morphology 2.92774359943846e-07 1.04787945375585e-05 1.84644425145945 0.472222222222222 19.1 19 1 abnormal limb bone morphology 0.000271915890106382 0.00346867064943397 1.84644425145945 0.472222222222222 19.1 19 1 abnormal gluconeogenesis 1.71178752583395e-05 0.000342013772731883 1.84005517100457 0.470588235294118 19.1 19 1 abnormal dendritic spine morphology 1.71178752583395e-05 0.000342013772731883 1.84005517100457 0.470588235294118 19.1 19 1 overexpanded pulmonary alveoli 0.000430411140872778 0.00487766611809128 1.84005517100457 0.470588235294118 19.1 19 1 abnormal brown adipose tissue morphology 0.000430411140872778 0.00487766611809128 1.84005517100457 0.470588235294118 19.1 19 1 abnormal nervous system development 0.000430411140872778 0.00487766611809128 1.84005517100457 0.470588235294118 19.1 19 1 abnormal adipose tissue morphology 0.0121916897042937 0.0633789511795833 1.84005517100457 0.470588235294118 19.1 19 1 abnormal bone marrow cavity morphology 0.0121916897042937 0.0633789511795833 1.84005517100457 0.470588235294118 19.1 19 1 hydroureter 0.0121916897042937 0.0633789511795833 1.84005517100457 0.470588235294118 19.1 19 1 hyperlipidemia 0.0121916897042937 0.0633789511795833 1.84005517100457 0.470588235294118 19.1 19 1 decreased vasoconstriction 0.0121916897042937 0.0633789511795833 1.84005517100457 0.470588235294118 19.1 19 1 abnormal testis development 0.0121916897042937 0.0633789511795833 1.84005517100457 0.470588235294118 19.1 19 1 enhanced behavioral response to cocaine 0.0121916897042937 0.0633789511795833 1.84005517100457 0.470588235294118 19.1 19 1 abnormal embryo size 2.2041669538097e-10 1.76866622503278e-08 1.83394879322469 0.469026548672566 19.1 19 1 bradykinesia 0.000682178964958615 0.00716000073980825 1.83286745549284 0.46875 19.1 19 1 increased fibroblast apoptosis 0.000682178964958615 0.00716000073980825 1.83286745549284 0.46875 19.1 19 1 abnormal somite development 1.16196952900421e-07 4.62463872543676e-06 1.8313207319017 0.468354430379747 19.1 19 1 prenatal lethality 2.73290355767948e-06 7.38923652144316e-05 1.82892580505092 0.467741935483871 19.1 19 1 abnormal eating behavior 4.27507286056202e-06 0.00010634243740648 1.82472137791287 0.466666666666667 19.1 19 1 muscular ventricular septal defect 4.27507286056202e-06 0.00010634243740648 1.82472137791287 0.466666666666667 19.1 19 1 trabecula carnea hypoplasia 6.63845250201566e-05 0.00110087670658426 1.82472137791287 0.466666666666667 19.1 19 1 delayed eyelid opening 0.00108279382313892 0.0101639608870116 1.82472137791287 0.466666666666667 19.1 19 1 abnormal response to new environment 0.00108279382313892 0.0101639608870116 1.82472137791287 0.466666666666667 19.1 19 1 abnormal prostate gland morphology 0.0198712167000468 0.0909469209592758 1.82472137791287 0.466666666666667 19.1 19 1 absent egg cylinders 0.0198712167000468 0.0909469209592758 1.82472137791287 0.466666666666667 19.1 19 1 placental labyrinth hypoplasia 0.0198712167000468 0.0909469209592758 1.82472137791287 0.466666666666667 19.1 19 1 abnormal ear development 0.0198712167000468 0.0909469209592758 1.82472137791287 0.466666666666667 19.1 19 1 abnormal zygomatic bone morphology 0.0198712167000468 0.0909469209592758 1.82472137791287 0.466666666666667 19.1 19 1 abnormal coronary vessel morphology 0.0198712167000468 0.0909469209592758 1.82472137791287 0.466666666666667 19.1 19 1 heterochrony 0.0198712167000468 0.0909469209592758 1.82472137791287 0.466666666666667 19.1 19 1 abnormal neurocranium morphology 2.82680246990423e-07 1.01908277447634e-05 1.82472137791287 0.466666666666667 19.1 19 1 reduced long term potentiation 5.13460005311299e-10 3.54786600892182e-08 1.81541157496433 0.464285714285714 19.1 19 1 abnormal jaw morphology 0.00172148939508414 0.0145550954682029 1.81541157496433 0.464285714285714 19.1 19 1 premature aging 0.00172148939508414 0.0145550954682029 1.81541157496433 0.464285714285714 19.1 19 1 abnormal brainstem morphology 0.00172148939508414 0.0145550954682029 1.81541157496433 0.464285714285714 19.1 19 1 abnormal mitotic spindle morphology 0.00172148939508414 0.0145550954682029 1.81541157496433 0.464285714285714 19.1 19 1 abnormal sternum morphology 1.07348282628516e-06 3.21721509684859e-05 1.81338770475813 0.463768115942029 19.1 19 1 palatal shelves fail to meet at midline 0.000164355804272596 0.00234289434457354 1.81200554949536 0.463414634146341 19.1 19 1 increased bone trabecula number 0.000164355804272596 0.00234289434457354 1.81200554949536 0.463414634146341 19.1 19 1 abnormal apoptosis 1.63912630621401e-05 0.000331489974529053 1.81023946221515 0.462962962962963 19.1 19 1 abnormal long bone epiphyseal plate proliferative zone 1.63912630621401e-05 0.000331489974529053 1.81023946221515 0.462962962962963 19.1 19 1 abnormal snout morphology 2.56701798877632e-05 0.00049499668582024 1.8046694946391 0.461538461538462 19.1 19 1 increased leukemia incidence 0.0027419988430058 0.0211495259596184 1.8046694946391 0.461538461538462 19.1 19 1 increased thymocyte apoptosis 0.0027419988430058 0.0211495259596184 1.8046694946391 0.461538461538462 19.1 19 1 absent teeth 0.0326133530641726 0.132126572878061 1.8046694946391 0.461538461538462 19.1 19 1 absent common myeloid progenitor cells 0.0326133530641726 0.132126572878061 1.8046694946391 0.461538461538462 19.1 19 1 uterus hypoplasia 0.0326133530641726 0.132126572878061 1.8046694946391 0.461538461538462 19.1 19 1 abnormal pulmonary alveolus epithelial cell morphology 0.0326133530641726 0.132126572878061 1.8046694946391 0.461538461538462 19.1 19 1 abnormal lung interstitium morphology 0.0326133530641726 0.132126572878061 1.8046694946391 0.461538461538462 19.1 19 1 increased synaptic depression 0.0326133530641726 0.132126572878061 1.8046694946391 0.461538461538462 19.1 19 1 abnormal retinal inner plexiform layer morphology 0.0326133530641726 0.132126572878061 1.8046694946391 0.461538461538462 19.1 19 1 small otic vesicle 0.0326133530641726 0.132126572878061 1.8046694946391 0.461538461538462 19.1 19 1 hyperalgesia 0.0326133530641726 0.132126572878061 1.8046694946391 0.461538461538462 19.1 19 1 abnormal aorta tunica media morphology 0.0326133530641726 0.132126572878061 1.8046694946391 0.461538461538462 19.1 19 1 abnormal extraembryonic tissue morphology 4.64235619575658e-09 2.5379914366911e-07 1.80172068827531 0.46078431372549 19.1 19 1 abnormal axial skeleton morphology 4.21572422480805e-07 1.44642951851173e-05 1.80071188609822 0.460526315789474 19.1 19 1 kidney cysts 6.56509698966429e-07 2.13472924990718e-05 1.79654035277136 0.459459459459459 19.1 19 1 abnormal hair follicle development 0.000408093579010561 0.0047407890371233 1.79654035277136 0.459459459459459 19.1 19 1 retinal degeneration 1.73828017169549e-08 8.23613700398577e-07 1.79213706759299 0.458333333333333 19.1 19 1 abnormal digit morphology 1.02239561347907e-06 3.13976430682616e-05 1.79213706759299 0.458333333333333 19.1 19 1 hydrops fetalis 1.02239561347907e-06 3.13976430682616e-05 1.79213706759299 0.458333333333333 19.1 19 1 curly tail 6.30227570723202e-05 0.001058320673026 1.79213706759299 0.458333333333333 19.1 19 1 abnormal malleus morphology 0.00437669444973664 0.0312059758223246 1.79213706759299 0.458333333333333 19.1 19 1 curly vibrissae 0.00437669444973664 0.0312059758223246 1.79213706759299 0.458333333333333 19.1 19 1 hemolytic anemia 0.00437669444973664 0.0312059758223246 1.79213706759299 0.458333333333333 19.1 19 1 apnea 0.00437669444973664 0.0312059758223246 1.79213706759299 0.458333333333333 19.1 19 1 pale yolk sac 1.65567872614224e-07 6.36179928314007e-06 1.79017415733276 0.457831325301205 19.1 19 1 syndactyly 9.94672278565992e-06 0.000211474127601103 1.7893756853625 0.457627118644068 19.1 19 1 abnormal embryonic epiblast morphology 0.000643854372107836 0.00688854946502469 1.78748216611873 0.457142857142857 19.1 19 1 holoprosencephaly 0.000643854372107836 0.00688854946502469 1.78748216611873 0.457142857142857 19.1 19 1 decreased circulating thyroxine level 0.000643854372107836 0.00688854946502469 1.78748216611873 0.457142857142857 19.1 19 1 decreased bone volume 0.000643854372107836 0.00688854946502469 1.78748216611873 0.457142857142857 19.1 19 1 respiratory distress 5.81172308519236e-14 8.76161283297939e-12 1.78554486608319 0.456647398843931 19.1 19 1 abnormal cell death 9.88019557489628e-05 0.00154087689608492 1.78505352187128 0.456521739130435 19.1 19 1 atrial septal defect 9.88019557489628e-05 0.00154087689608492 1.78505352187128 0.456521739130435 19.1 19 1 abnormal craniofacial morphology 6.85591671141578e-09 3.55293600409307e-07 1.78422825440856 0.456310679611651 19.1 19 1 abnormal embryonic tissue morphology 5.06752007748676e-12 5.36402391180779e-10 1.78216227871956 0.45578231292517 19.1 19 1 abnormal CNS synaptic transmission 1.648417298711e-08 8.04007456969335e-07 1.7773260174476 0.454545454545455 19.1 19 1 omphalocele 0.000154953268722777 0.00224750003468168 1.7773260174476 0.454545454545455 19.1 19 1 enlarged pericardium 0.00101676172289877 0.0097652308328598 1.7773260174476 0.454545454545455 19.1 19 1 abnormal germ layer development 0.00700287824509166 0.0437132060021873 1.7773260174476 0.454545454545455 19.1 19 1 testis hypoplasia 0.00700287824509166 0.0437132060021873 1.7773260174476 0.454545454545455 19.1 19 1 abnormal vascular branching morphogenesis 0.00700287824509166 0.0437132060021873 1.7773260174476 0.454545454545455 19.1 19 1 abnormal female reproductive system physiology 0.00700287824509166 0.0437132060021873 1.7773260174476 0.454545454545455 19.1 19 1 abnormal basement membrane morphology 0.00700287824509166 0.0437132060021873 1.7773260174476 0.454545454545455 19.1 19 1 decreased circulating estradiol level 0.00700287824509166 0.0437132060021873 1.7773260174476 0.454545454545455 19.1 19 1 abnormal occipital bone morphology 0.00700287824509166 0.0437132060021873 1.7773260174476 0.454545454545455 19.1 19 1 decreased atrioventricular cushion size 0.0540089783998817 0.18607663957023 1.7773260174476 0.454545454545455 19.1 19 1 enlarged cranium 0.0540089783998817 0.18607663957023 1.7773260174476 0.454545454545455 19.1 19 1 abnormal glossopharyngeal ganglion morphology 0.0540089783998817 0.18607663957023 1.7773260174476 0.454545454545455 19.1 19 1 abnormal food preference 0.0540089783998817 0.18607663957023 1.7773260174476 0.454545454545455 19.1 19 1 abnormal hemoglobin 0.0540089783998817 0.18607663957023 1.7773260174476 0.454545454545455 19.1 19 1 retinal detachment 0.0540089783998817 0.18607663957023 1.7773260174476 0.454545454545455 19.1 19 1 loss of cortex neurons 0.0540089783998817 0.18607663957023 1.7773260174476 0.454545454545455 19.1 19 1 pharyngeal arch hypoplasia 0.0540089783998817 0.18607663957023 1.7773260174476 0.454545454545455 19.1 19 1 cyclopia 0.0540089783998817 0.18607663957023 1.7773260174476 0.454545454545455 19.1 19 1 increased motor neuron number 0.0540089783998817 0.18607663957023 1.7773260174476 0.454545454545455 19.1 19 1 increased glycogen level 0.0540089783998817 0.18607663957023 1.7773260174476 0.454545454545455 19.1 19 1 abnormal superovulation 0.0540089783998817 0.18607663957023 1.7773260174476 0.454545454545455 19.1 19 1 common atrioventricular valve 0.0540089783998817 0.18607663957023 1.7773260174476 0.454545454545455 19.1 19 1 decreased core body temperature 0.0540089783998817 0.18607663957023 1.7773260174476 0.454545454545455 19.1 19 1 increased tumor incidence 4.20339940424129e-10 2.9874160051572e-08 1.76585939798019 0.451612903225806 19.1 19 1 osteopetrosis 0.00160727966736045 0.0141525953010942 1.76585939798019 0.451612903225806 19.1 19 1 abnormal kidney development 1.45871636334674e-05 0.000298646662866256 1.75955275727312 0.45 19.1 19 1 abnormal basioccipital bone morphology 0.0112363226413709 0.0591653287415945 1.75955275727312 0.45 19.1 19 1 abnormal pericardium morphology 0.0112363226413709 0.0591653287415945 1.75955275727312 0.45 19.1 19 1 abnormal vascular regression 0.0112363226413709 0.0591653287415945 1.75955275727312 0.45 19.1 19 1 abnormal hearing physiology 0.0112363226413709 0.0591653287415945 1.75955275727312 0.45 19.1 19 1 absent placental labyrinth 0.0112363226413709 0.0591653287415945 1.75955275727312 0.45 19.1 19 1 abnormal heart right ventricle morphology 0.0112363226413709 0.0591653287415945 1.75955275727312 0.45 19.1 19 1 abnormal optic stalk morphology 0.0112363226413709 0.0591653287415945 1.75955275727312 0.45 19.1 19 1 abnormal induced retinal neovascularization 0.0112363226413709 0.0591653287415945 1.75955275727312 0.45 19.1 19 1 abnormal neuron proliferation 0.0112363226413709 0.0591653287415945 1.75955275727312 0.45 19.1 19 1 increased skin tumor incidence 0.0112363226413709 0.0591653287415945 1.75955275727312 0.45 19.1 19 1 absent ductus venosus valve 0.0112363226413709 0.0591653287415945 1.75955275727312 0.45 19.1 19 1 abnormal craniofacial development 9.2472878916692e-05 0.00146048435749379 1.75556284172375 0.448979591836735 19.1 19 1 decreased retinal photoreceptor cell number 0.00254358120939546 0.0200543843371512 1.75281117582763 0.448275862068966 19.1 19 1 increased mortality induced by gamma-irradiation 0.00254358120939546 0.0200543843371512 1.75281117582763 0.448275862068966 19.1 19 1 decreased trophoblast giant cell number 0.00254358120939546 0.0200543843371512 1.75281117582763 0.448275862068966 19.1 19 1 abnormal frontal bone morphology 0.000599227864728817 0.00646672153367866 1.74926297506685 0.447368421052632 19.1 19 1 lethality throughout fetal growth and development, incomplete penetrance 1.70003624256304e-13 2.3493556407642e-11 1.747538430563 0.446927374301676 19.1 19 1 cleft secondary palate 8.91798134972025e-08 3.6666906789139e-06 1.74707365970381 0.446808510638298 19.1 19 1 abnormal cell nucleus morphology 0.000144494800375885 0.00210809862718484 1.74707365970381 0.446808510638298 19.1 19 1 perinatal lethality, complete penetrance 1.12616973172388e-15 2.24107776613052e-13 1.74394900303544 0.446009389671362 19.1 19 1 increased granulocyte number 2.18263917114676e-06 5.99924302566581e-05 1.74370093063102 0.445945945945946 19.1 19 1 abnormal eye muscle morphology 0.00403020532854562 0.0292278010342777 1.73782988372654 0.444444444444444 19.1 19 1 abnormal bone trabecula morphology 0.00403020532854562 0.0292278010342777 1.73782988372654 0.444444444444444 19.1 19 1 decreased circulating serum albumin level 5.38737631651402e-08 2.29078608330404e-06 1.73782988372654 0.444444444444444 19.1 19 1 increased neuron apoptosis 8.47421114010013e-07 2.65152203911938e-05 1.73782988372654 0.444444444444444 19.1 19 1 absent ureter 0.0180881864307966 0.0843199188663634 1.73782988372654 0.444444444444444 19.1 19 1 jerky movement 0.0180881864307966 0.0843199188663634 1.73782988372654 0.444444444444444 19.1 19 1 decreased tumor latency 0.0180881864307966 0.0843199188663634 1.73782988372654 0.444444444444444 19.1 19 1 abnormal hypoglossal nerve topology 0.0180881864307966 0.0843199188663634 1.73782988372654 0.444444444444444 19.1 19 1 abnormal placenta vasculature 8.5770404941002e-05 0.00137205068997262 1.72947493236247 0.442307692307692 19.1 19 1 kinked neural tube 8.5770404941002e-05 0.00137205068997262 1.72947493236247 0.442307692307692 19.1 19 1 increased oxygen consumption 5.09442726452609e-07 1.70099165375955e-05 1.72772622161185 0.441860465116279 19.1 19 1 abnormal organ of Corti morphology 0.00035291533737595 0.00419034320631349 1.72772622161185 0.441860465116279 19.1 19 1 abnormal axon guidance 0.00035291533737595 0.00419034320631349 1.72772622161185 0.441860465116279 19.1 19 1 impaired synaptic plasticity 0.00147967007712982 0.0131687989869783 1.72505172281679 0.441176470588235 19.1 19 1 abnormal direction of heart looping 0.00147967007712982 0.0131687989869783 1.72505172281679 0.441176470588235 19.1 19 1 increased B cell derived lymphoma incidence 0.000133532651745852 0.00196545840957282 1.72045158488927 0.44 19.1 19 1 decreased circulating alkaline phosphatase level 0.000133532651745852 0.00196545840957282 1.72045158488927 0.44 19.1 19 1 mandible hypoplasia 0.00639419653521553 0.0415831735460095 1.72045158488927 0.44 19.1 19 1 diaphragmatic hernia 0.00639419653521553 0.0415831735460095 1.72045158488927 0.44 19.1 19 1 small spleen 3.05918127974638e-07 1.07716740279649e-05 1.71873285203724 0.43956043956044 19.1 19 1 thick ventricular wall 0.000551613363360789 0.00604466185621129 1.71663683636402 0.439024390243902 19.1 19 1 reduced fertility 2.99587836893532e-10 2.22455147544078e-08 1.71595073051416 0.438848920863309 19.1 19 1 decreased body size 4.0627968763844e-52 1.01062072300062e-48 1.71496370104593 0.43859649122807 19.1 19 1 neonatal lethality, incomplete penetrance 8.03200455388876e-18 2.21995681419981e-15 1.71443601990714 0.438461538461538 19.1 19 1 abnormal lipid homeostasis 1.17463815446856e-09 7.58938288114428e-08 1.71443601990714 0.438461538461538 19.1 19 1 abnormal neural tube morphology 1.18017723527129e-11 1.16985518511364e-09 1.71369335756367 0.438271604938272 19.1 19 1 decreased body length 1.2412831645702e-18 3.85961483983547e-16 1.71246010440207 0.437956204379562 19.1 19 1 microphthalmia 4.61497491133095e-11 4.0279824883985e-09 1.71227356190703 0.437908496732026 19.1 19 1 abnormal posture 1.87631787870971e-06 5.18593413698934e-05 1.71067629179331 0.4375 19.1 19 1 neonatal lethality 0.00232680243589521 0.0184622681317044 1.71067629179331 0.4375 19.1 19 1 delayed hair appearance 0.0292312958291624 0.12008728055333 1.71067629179331 0.4375 19.1 19 1 disorganized yolk sac vascular plexus 0.0292312958291624 0.12008728055333 1.71067629179331 0.4375 19.1 19 1 intraventricular hemorrhage 0.0292312958291624 0.12008728055333 1.71067629179331 0.4375 19.1 19 1 abnormal olfaction 0.0292312958291624 0.12008728055333 1.71067629179331 0.4375 19.1 19 1 white spotting 0.0292312958291624 0.12008728055333 1.71067629179331 0.4375 19.1 19 1 increased intestinal adenocarcinoma incidence 0.0292312958291624 0.12008728055333 1.71067629179331 0.4375 19.1 19 1 increased pancreatic beta cell number 0.0292312958291624 0.12008728055333 1.71067629179331 0.4375 19.1 19 1 small pancreas 0.0292312958291624 0.12008728055333 1.71067629179331 0.4375 19.1 19 1 impaired somite development 0.0292312958291624 0.12008728055333 1.71067629179331 0.4375 19.1 19 1 lethality throughout fetal growth and development, complete penetrance 2.81629867557307e-13 3.68712787130948e-11 1.70810384624174 0.436842105263158 19.1 19 1 abnormal ovary morphology 7.49930876659464e-06 0.000168058833845984 1.70723428718206 0.436619718309859 19.1 19 1 decreased liver weight 7.49930876659464e-06 0.000168058833845984 1.70723428718206 0.436619718309859 19.1 19 1 abnormal excitatory postsynaptic currents 2.89545486401184e-06 7.70314863553953e-05 1.70441007827026 0.435897435897436 19.1 19 1 abnormal iris morphology 0.000862222234258995 0.00863089661054025 1.70441007827026 0.435897435897436 19.1 19 1 failure of heart looping 0.000862222234258995 0.00863089661054025 1.70441007827026 0.435897435897436 19.1 19 1 reduced female fertility 1.03993907330357e-15 2.18691217435013e-13 1.70224931498645 0.435344827586207 19.1 19 1 blistering 0.0101595765689344 0.0564105953464826 1.70005097321075 0.434782608695652 19.1 19 1 hypotension 0.0101595765689344 0.0564105953464826 1.70005097321075 0.434782608695652 19.1 19 1 abnormal cochlear ganglion morphology 0.0101595765689344 0.0564105953464826 1.70005097321075 0.434782608695652 19.1 19 1 abnormal palatal shelf fusion at midline 0.0101595765689344 0.0564105953464826 1.70005097321075 0.434782608695652 19.1 19 1 abnormal hematopoietic stem cell physiology 0.0101595765689344 0.0564105953464826 1.70005097321075 0.434782608695652 19.1 19 1 abnormal vertebral artery topology 0.0101595765689344 0.0564105953464826 1.70005097321075 0.434782608695652 19.1 19 1 hemorrhage 9.59805348121355e-16 2.17046891222897e-13 1.69715726942656 0.434042553191489 19.1 19 1 abnormal neural tube closure 1.72705419011565e-06 4.93798539989963e-05 1.69595446484156 0.433734939759036 19.1 19 1 abnormal optic cup morphology 0.00366065391653281 0.0268214333354208 1.69438413663338 0.433333333333333 19.1 19 1 decreased compact bone thickness 1.78924175049169e-05 0.000356059108347846 1.69243880467398 0.432835820895522 19.1 19 1 abnormal angiogenesis 6.88593566887739e-06 0.000159337348617047 1.69086150849069 0.432432432432432 19.1 19 1 impaired skeletal muscle contractility 0.00134773778909827 0.012174934150272 1.69086150849069 0.432432432432432 19.1 19 1 short femur 1.0298048246115e-06 3.14311595241854e-05 1.68845971657522 0.431818181818182 19.1 19 1 abnormal motor capabilities/coordination/movement 2.35557549971383e-09 1.37870448365604e-07 1.68845971657522 0.431818181818182 19.1 19 1 decreased circulating cholesterol level 2.19421537092466e-12 2.48095942507958e-10 1.68797410837373 0.431693989071038 19.1 19 1 decreased birth weight 3.99742390985336e-07 1.38105444107781e-05 1.68752428182919 0.431578947368421 19.1 19 1 abnormal response to novel object 0.000189932336242993 0.00258880376112025 1.68671724008752 0.431372549019608 19.1 19 1 abnormal trophoblast layer morphology 0.000189932336242993 0.00258880376112025 1.68671724008752 0.431372549019608 19.1 19 1 ataxia 2.03361178207894e-13 2.73438340968723e-11 1.68406039474985 0.430693069306931 19.1 19 1 abnormal myocardium layer morphology 4.09226219445038e-06 0.000103872471517299 1.68283526715292 0.430379746835443 19.1 19 1 abnormal rib morphology 2.16166817074224e-09 1.28027370826698e-07 1.67990222093566 0.42962962962963 19.1 19 1 pallor 1.19924853147328e-11 1.16985518511364e-09 1.67576453073631 0.428571428571429 19.1 19 1 abnormal brain morphology 7.7905338484326e-11 6.68239756826762e-09 1.67576453073631 0.428571428571429 19.1 19 1 organ of Corti degeneration 0.000294403744855687 0.00365251528842155 1.67576453073631 0.428571428571429 19.1 19 1 liver degeneration 0.0161678257119817 0.0794811590090008 1.67576453073631 0.428571428571429 19.1 19 1 abnormal erythrocyte physiology 0.0161678257119817 0.0794811590090008 1.67576453073631 0.428571428571429 19.1 19 1 abnormal clavicle morphology 0.0161678257119817 0.0794811590090008 1.67576453073631 0.428571428571429 19.1 19 1 absent segment of posterior cerebral artery 0.0161678257119817 0.0794811590090008 1.67576453073631 0.428571428571429 19.1 19 1 increased bone ossification 0.0161678257119817 0.0794811590090008 1.67576453073631 0.428571428571429 19.1 19 1 rib bifurcation 0.00576174227864172 0.038016800843823 1.67576453073631 0.428571428571429 19.1 19 1 prolonged QRS complex duration 0.00576174227864172 0.038016800843823 1.67576453073631 0.428571428571429 19.1 19 1 midline facial cleft 0.0474584329702928 0.166741316403395 1.67576453073631 0.428571428571429 19.1 19 1 abnormal blood flow velocity 0.0474584329702928 0.166741316403395 1.67576453073631 0.428571428571429 19.1 19 1 abnormal vasoconstriction 0.0474584329702928 0.166741316403395 1.67576453073631 0.428571428571429 19.1 19 1 abnormal kidney blood vessel morphology 0.0474584329702928 0.166741316403395 1.67576453073631 0.428571428571429 19.1 19 1 translucent skin 0.0474584329702928 0.166741316403395 1.67576453073631 0.428571428571429 19.1 19 1 irregularly shaped pupil 0.0474584329702928 0.166741316403395 1.67576453073631 0.428571428571429 19.1 19 1 abnormal pinna reflex 0.0474584329702928 0.166741316403395 1.67576453073631 0.428571428571429 19.1 19 1 abnormal spleen periarteriolar lymphoid sheath morphology 0.0474584329702928 0.166741316403395 1.67576453073631 0.428571428571429 19.1 19 1 abnormal prepulse inhibition 0.0474584329702928 0.166741316403395 1.67576453073631 0.428571428571429 19.1 19 1 intestinal obstruction 0.0474584329702928 0.166741316403395 1.67576453073631 0.428571428571429 19.1 19 1 abnormal ventral body wall morphology 0.0474584329702928 0.166741316403395 1.67576453073631 0.428571428571429 19.1 19 1 split sternum 0.0474584329702928 0.166741316403395 1.67576453073631 0.428571428571429 19.1 19 1 abnormal viscerocranium morphology 0.0474584329702928 0.166741316403395 1.67576453073631 0.428571428571429 19.1 19 1 decreased cornea thickness 0.0474584329702928 0.166741316403395 1.67576453073631 0.428571428571429 19.1 19 1 decreased compact bone area 0.0474584329702928 0.166741316403395 1.67576453073631 0.428571428571429 19.1 19 1 abnormal renal tubule epithelial cell primary cilium morphology 0.0474584329702928 0.166741316403395 1.67576453073631 0.428571428571429 19.1 19 1 testis degeneration 0.0474584329702928 0.166741316403395 1.67576453073631 0.428571428571429 19.1 19 1 neonatal lethality, complete penetrance 8.92689317917561e-28 4.9345881740443e-25 1.67208960851978 0.427631578947368 19.1 19 1 prenatal lethality, incomplete penetrance 5.41643389552919e-19 1.79645057535052e-16 1.67208960851978 0.427631578947368 19.1 19 1 abnormal blood vessel morphology 7.74864796238001e-10 5.28075665929323e-08 1.67191219848174 0.427586206896552 19.1 19 1 abnormal cochlea morphology 0.000172482243764653 0.00243087581509674 1.66542030523793 0.425925925925926 19.1 19 1 abnormal small intestine morphology 0.000172482243764653 0.00243087581509674 1.66542030523793 0.425925925925926 19.1 19 1 axon degeneration 0.000172482243764653 0.00243087581509674 1.66542030523793 0.425925925925926 19.1 19 1 neuron degeneration 0.000456105885309417 0.00504250395425411 1.66387967590839 0.425531914893617 19.1 19 1 head bobbing 0.00121746634464822 0.0111545028814455 1.6617998263135 0.425 19.1 19 1 increased susceptibility to weight loss 0.00121746634464822 0.0111545028814455 1.6617998263135 0.425 19.1 19 1 abnormal seminiferous tubule morphology 1.08015161529352e-09 7.07072932379641e-08 1.66046074506748 0.424657534246575 19.1 19 1 extramedullary hematopoiesis 1.98762169204252e-07 7.37941635665041e-06 1.65995543138974 0.424528301886792 19.1 19 1 dextrocardia 0.00329209559283995 0.0244086074133812 1.65883761628442 0.424242424242424 19.1 19 1 postnatal growth retardation 1.40572304478361e-35 1.39869442955969e-32 1.65477183781314 0.423202614379085 19.1 19 1 absent gastric milk in neonates 8.78654574621405e-06 0.000191723969681644 1.65428037008584 0.423076923076923 19.1 19 1 distended pericardium 0.000266317752531119 0.00342808601334031 1.65428037008584 0.423076923076923 19.1 19 1 decreased circulating glycerol level 0.009072474842836 0.0512321933519967 1.65428037008584 0.423076923076923 19.1 19 1 atelectasis 2.28135825185704e-05 0.000446840838700345 1.65216221340199 0.422535211267606 19.1 19 1 abnormal autopod morphology 0.000706197535378602 0.00728165380510043 1.65093838954021 0.422222222222222 19.1 19 1 abnormal myocardial trabeculae morphology 0.000706197535378602 0.00728165380510043 1.65093838954021 0.422222222222222 19.1 19 1 abnormal cell migration 0.000706197535378602 0.00728165380510043 1.65093838954021 0.422222222222222 19.1 19 1 lethality at weaning, complete penetrance 0.000706197535378602 0.00728165380510043 1.65093838954021 0.422222222222222 19.1 19 1 decreased total body fat amount 7.30948738475128e-20 2.59747855279554e-17 1.650678235366 0.422155688622754 19.1 19 1 impaired coordination 1.71186207529472e-20 6.55116448045478e-18 1.64993386359586 0.421965317919075 19.1 19 1 decreased circulating LDL cholesterol level 5.9473086000104e-05 0.00101556873485032 1.64958070994355 0.421875 19.1 19 1 decreased cell proliferation 1.26707891693059e-11 1.21225338687109e-09 1.64858997077842 0.421621621621622 19.1 19 1 decreased neuron apoptosis 0.00189210864318516 0.0153560203912662 1.64636515300409 0.421052631578947 19.1 19 1 abnormal compact bone morphology 0.00189210864318516 0.0153560203912662 1.64636515300409 0.421052631578947 19.1 19 1 decreased threshold for auditory brainstem response 0.00189210864318516 0.0153560203912662 1.64636515300409 0.421052631578947 19.1 19 1 delayed sexual maturation 0.025773144560454 0.111886033323088 1.64636515300409 0.421052631578947 19.1 19 1 abnormal neural crest cell migration 0.025773144560454 0.111886033323088 1.64636515300409 0.421052631578947 19.1 19 1 abnormal response to novelty 0.025773144560454 0.111886033323088 1.64636515300409 0.421052631578947 19.1 19 1 increased left ventricle weight 0.025773144560454 0.111886033323088 1.64636515300409 0.421052631578947 19.1 19 1 decreased liver regeneration 0.025773144560454 0.111886033323088 1.64636515300409 0.421052631578947 19.1 19 1 Leydig cell hypoplasia 0.025773144560454 0.111886033323088 1.64636515300409 0.421052631578947 19.1 19 1 decreased susceptibility to weight gain 0.025773144560454 0.111886033323088 1.64636515300409 0.421052631578947 19.1 19 1 shortened RR interval 0.025773144560454 0.111886033323088 1.64636515300409 0.421052631578947 19.1 19 1 hyperactivity 1.29439466927644e-21 5.36634456637523e-19 1.64414633204317 0.420485175202156 19.1 19 1 small kidney 3.07679854303256e-06 8.05635407978264e-05 1.64402656613903 0.420454545454545 19.1 19 1 abnormal hindlimb morphology 0.0004108966053835 0.0047407890371233 1.64224924012158 0.42 19.1 19 1 abnormal skeleton development 7.95167958824112e-06 0.000176398407817884 1.64128377907507 0.419753086419753 19.1 19 1 increased insulin sensitivity 3.46988356763062e-09 1.9396259268497e-07 1.64060863149009 0.41958041958042 19.1 19 1 abnormal capillary morphology 0.00514364642982396 0.034302467812834 1.63972658383875 0.419354838709677 19.1 19 1 decreased thymus weight 0.00514364642982396 0.034302467812834 1.63972658383875 0.419354838709677 19.1 19 1 abnormal intestine morphology 2.06121558581741e-05 0.000408547710734726 1.63802208635035 0.418918918918919 19.1 19 1 abnormal vasculogenesis 0.00109263905882552 0.0102178182662725 1.63679326257965 0.418604651162791 19.1 19 1 abnormal double-strand DNA break repair 0.00109263905882552 0.0102178182662725 1.63679326257965 0.418604651162791 19.1 19 1 decreased circulating calcium level 0.000239706165867032 0.00315486289732403 1.63513993605179 0.418181818181818 19.1 19 1 rib fusion 5.3626533248413e-05 0.000932839171016974 1.63407884589212 0.417910447761194 19.1 19 1 abnormal placenta morphology 1.21541839463924e-05 0.000251946104722092 1.63334011223665 0.417721518987342 19.1 19 1 limb grasping 4.03072032907503e-11 3.64596975220878e-09 1.63279620943538 0.417582417582418 19.1 19 1 abnormal spatial learning 4.37819146083862e-10 3.06781725601016e-08 1.63121455343657 0.417177914110429 19.1 19 1 abnormal digestive system morphology 0.0142902066540756 0.0710227553486775 1.62921551599363 0.416666666666667 19.1 19 1 abnormal body weight 0.0142902066540756 0.0710227553486775 1.62921551599363 0.416666666666667 19.1 19 1 increased stereotypic behavior 0.0142902066540756 0.0710227553486775 1.62921551599363 0.416666666666667 19.1 19 1 abnormal startle reflex 0.0142902066540756 0.0710227553486775 1.62921551599363 0.416666666666667 19.1 19 1 abnormal vasodilation 0.0142902066540756 0.0710227553486775 1.62921551599363 0.416666666666667 19.1 19 1 abnormal sensory capabilities/reflexes/nociception 0.0142902066540756 0.0710227553486775 1.62921551599363 0.416666666666667 19.1 19 1 decreased ovulation rate 0.0142902066540756 0.0710227553486775 1.62921551599363 0.416666666666667 19.1 19 1 abnormal osteoblast morphology 0.0142902066540756 0.0710227553486775 1.62921551599363 0.416666666666667 19.1 19 1 abnormal mineral level 0.0774846878263121 0.239283874572255 1.62921551599363 0.416666666666667 19.1 19 1 abnormal superior cervical ganglion morphology 0.0774846878263121 0.239283874572255 1.62921551599363 0.416666666666667 19.1 19 1 abnormal glossopharyngeal nerve morphology 0.0774846878263121 0.239283874572255 1.62921551599363 0.416666666666667 19.1 19 1 absent optic nerve 0.0774846878263121 0.239283874572255 1.62921551599363 0.416666666666667 19.1 19 1 increased litter size 0.0774846878263121 0.239283874572255 1.62921551599363 0.416666666666667 19.1 19 1 increased papilloma incidence 0.0774846878263121 0.239283874572255 1.62921551599363 0.416666666666667 19.1 19 1 abnormal respiratory function 0.0774846878263121 0.239283874572255 1.62921551599363 0.416666666666667 19.1 19 1 increased circulating parathyroid hormone level 0.0774846878263121 0.239283874572255 1.62921551599363 0.416666666666667 19.1 19 1 abnormal aorta elastic fiber morphology 0.0774846878263121 0.239283874572255 1.62921551599363 0.416666666666667 19.1 19 1 decreased left ventricle systolic pressure 0.0774846878263121 0.239283874572255 1.62921551599363 0.416666666666667 19.1 19 1 pale placenta 0.0774846878263121 0.239283874572255 1.62921551599363 0.416666666666667 19.1 19 1 vestibular saccular macula degeneration 0.0774846878263121 0.239283874572255 1.62921551599363 0.416666666666667 19.1 19 1 abnormal cochlear outer hair cell physiology 0.0774846878263121 0.239283874572255 1.62921551599363 0.416666666666667 19.1 19 1 abnormal palatine bone morphology 0.0774846878263121 0.239283874572255 1.62921551599363 0.416666666666667 19.1 19 1 abnormal patella morphology 0.0774846878263121 0.239283874572255 1.62921551599363 0.416666666666667 19.1 19 1 impaired behavioral response to cocaine 0.0774846878263121 0.239283874572255 1.62921551599363 0.416666666666667 19.1 19 1 increased fibrosarcoma incidence 0.0774846878263121 0.239283874572255 1.62921551599363 0.416666666666667 19.1 19 1 increased skeletal muscle glycogen level 0.0774846878263121 0.239283874572255 1.62921551599363 0.416666666666667 19.1 19 1 prenatal growth retardation 0.0774846878263121 0.239283874572255 1.62921551599363 0.416666666666667 19.1 19 1 abnormal respiratory motile cilium morphology 0.0774846878263121 0.239283874572255 1.62921551599363 0.416666666666667 19.1 19 1 abnormal vitelline vein connection 0.0774846878263121 0.239283874572255 1.62921551599363 0.416666666666667 19.1 19 1 intracranial hemorrhage 0.000140154161874059 0.00205078516271601 1.62921551599363 0.416666666666667 19.1 19 1 abnormal uterus morphology 0.00293876521174439 0.0221185430082123 1.62921551599363 0.416666666666667 19.1 19 1 reduced long term depression 0.00293876521174439 0.0221185430082123 1.62921551599363 0.416666666666667 19.1 19 1 postnatal lethality 3.95706083825184e-10 2.85309821308738e-08 1.62528969547316 0.41566265060241 19.1 19 1 abnormal excitatory postsynaptic potential 1.09389798796423e-05 0.000229626265405993 1.62126812323269 0.414634146341463 19.1 19 1 abnormal mammary gland development 0.00168911220639348 0.0145550954682029 1.62126812323269 0.414634146341463 19.1 19 1 abnormal cholesterol homeostasis 0.00168911220639348 0.0145550954682029 1.62126812323269 0.414634146341463 19.1 19 1 lethality at weaning, incomplete penetrance 0.00168911220639348 0.0145550954682029 1.62126812323269 0.414634146341463 19.1 19 1 embryonic lethality during organogenesis, complete penetrance 2.39734709567125e-30 1.70382882870921e-27 1.6199057130451 0.414285714285714 19.1 19 1 abnormal retina morphology 2.74570754927813e-12 3.03553223503526e-10 1.6199057130451 0.414285714285714 19.1 19 1 embryonic lethality between somite formation and embryo turning, complete penetrance 4.81833348228077e-05 0.000850042874976838 1.6199057130451 0.414285714285714 19.1 19 1 abnormal middle ear morphology 0.00803338538634498 0.0471854690638327 1.61797954691781 0.413793103448276 19.1 19 1 abnormal spinal nerve morphology 0.00803338538634498 0.0471854690638327 1.61797954691781 0.413793103448276 19.1 19 1 abnormal embryonic erythropoiesis 0.00803338538634498 0.0471854690638327 1.61797954691781 0.413793103448276 19.1 19 1 polychromatophilia 0.00803338538634498 0.0471854690638327 1.61797954691781 0.413793103448276 19.1 19 1 prenatal lethality, complete penetrance 1.0549928077267e-15 2.18691217435013e-13 1.61749454105843 0.413669064748201 19.1 19 1 abnormal bone mineralization 1.20411915110633e-07 4.71692344626298e-06 1.61575092495236 0.413223140495868 19.1 19 1 abnormal forelimb morphology 0.000975499391790362 0.00942351354205252 1.61504842455021 0.41304347826087 19.1 19 1 abnormal myelin sheath morphology 0.000975499391790362 0.00942351354205252 1.61504842455021 0.41304347826087 19.1 19 1 decreased susceptibility to hepatic steatosis 0.000125584624229596 0.00188756346085269 1.61369917774607 0.412698412698413 19.1 19 1 abnormal embryo development 2.51970338433046e-08 1.16069669787445e-06 1.610048274629 0.411764705882353 19.1 19 1 distended abdomen 0.000565571593781854 0.00617043569970334 1.610048274629 0.411764705882353 19.1 19 1 abnormal gastrulation 0.000565571593781854 0.00617043569970334 1.610048274629 0.411764705882353 19.1 19 1 enlarged liver sinusoidal spaces 0.00456079345383704 0.0322758853952194 1.610048274629 0.411764705882353 19.1 19 1 lung hemorrhage 0.00456079345383704 0.0322758853952194 1.610048274629 0.411764705882353 19.1 19 1 abnormal endoderm development 0.00456079345383704 0.0322758853952194 1.610048274629 0.411764705882353 19.1 19 1 abnormal spleen red pulp morphology 0.00456079345383704 0.0322758853952194 1.610048274629 0.411764705882353 19.1 19 1 abnormal dorsal-ventral axis patterning 0.0411590201165705 0.149044361151908 1.610048274629 0.411764705882353 19.1 19 1 abnormal tarsal bone morphology 0.0411590201165705 0.149044361151908 1.610048274629 0.411764705882353 19.1 19 1 decreased growth hormone level 0.0411590201165705 0.149044361151908 1.610048274629 0.411764705882353 19.1 19 1 pancytopenia 0.0411590201165705 0.149044361151908 1.610048274629 0.411764705882353 19.1 19 1 increased circulating magnesium level 0.0411590201165705 0.149044361151908 1.610048274629 0.411764705882353 19.1 19 1 abnormal survival 0.0411590201165705 0.149044361151908 1.610048274629 0.411764705882353 19.1 19 1 increased trabecular bone mass 0.0411590201165705 0.149044361151908 1.610048274629 0.411764705882353 19.1 19 1 abnormal ductus venosus valve morphology 0.0411590201165705 0.149044361151908 1.610048274629 0.411764705882353 19.1 19 1 thin ventricular wall 5.79073121052714e-06 0.000134620970898937 1.60749264244705 0.411111111111111 19.1 19 1 decreased percent body fat/body weight 4.31581181863662e-05 0.000772344021500617 1.6068974952266 0.410958904109589 19.1 19 1 abnormal cornea morphology 2.53607906965174e-05 0.000490933594222467 1.60415066190142 0.41025641025641 19.1 19 1 small lens 0.00260855136243814 0.0205340870698255 1.60415066190142 0.41025641025641 19.1 19 1 abnormal behavior 2.94729580626105e-15 5.43066542079582e-13 1.60342937113618 0.410071942446043 19.1 19 1 decreased embryo size 3.51208357335666e-25 1.58841961613176e-22 1.60331167096947 0.410041841004184 19.1 19 1 reduced male fertility 1.07404011285658e-12 1.24263943289803e-10 1.60194230471268 0.409691629955947 19.1 19 1 abnormal tail morphology 0.000112163356924937 0.00171800885594215 1.59959341570284 0.409090909090909 19.1 19 1 cochlear hair cell degeneration 0.00150059697755309 0.0132837543831435 1.59959341570284 0.409090909090909 19.1 19 1 abnormal amino acid level 0.00150059697755309 0.0132837543831435 1.59959341570284 0.409090909090909 19.1 19 1 embryonic lethality, incomplete penetrance 0.00150059697755309 0.0132837543831435 1.59959341570284 0.409090909090909 19.1 19 1 abnormal abdominal fat pad morphology 0.0225127893429055 0.0989409248948366 1.59959341570284 0.409090909090909 19.1 19 1 decreased cardiac output 0.0225127893429055 0.0989409248948366 1.59959341570284 0.409090909090909 19.1 19 1 abnormal circulating lipid level 0.0225127893429055 0.0989409248948366 1.59959341570284 0.409090909090909 19.1 19 1 abnormal limb posture 0.0225127893429055 0.0989409248948366 1.59959341570284 0.409090909090909 19.1 19 1 abnormal temporal bone morphology 0.0225127893429055 0.0989409248948366 1.59959341570284 0.409090909090909 19.1 19 1 abnormal sperm midpiece morphology 0.0225127893429055 0.0989409248948366 1.59959341570284 0.409090909090909 19.1 19 1 corneal opacity 6.57005447471624e-05 0.00109317796025797 1.59709013962193 0.408450704225352 19.1 19 1 polydactyly 3.06012803814166e-06 8.05509893637819e-05 1.59596621974886 0.408163265306122 19.1 19 1 abnormal mandible morphology 0.000503086896241444 0.00552507132185691 1.59301072674933 0.407407407407407 19.1 19 1 decreased tumor growth/size 0.000503086896241444 0.00552507132185691 1.59301072674933 0.407407407407407 19.1 19 1 abnormal type II pneumocyte morphology 0.0125390351339106 0.0647503588088 1.59301072674933 0.407407407407407 19.1 19 1 decreased susceptibility to pharmacologically induced seizures 0.0125390351339106 0.0647503588088 1.59301072674933 0.407407407407407 19.1 19 1 abnormal single cell response 0.0125390351339106 0.0647503588088 1.59301072674933 0.407407407407407 19.1 19 1 decreased circulating fructosamine level 0.0125390351339106 0.0647503588088 1.59301072674933 0.407407407407407 19.1 19 1 edema 8.93174112287659e-10 5.92472161150814e-08 1.59132678306355 0.406976744186047 19.1 19 1 kyphosis 1.07972748369035e-08 5.48126962383624e-07 1.59011434360978 0.406666666666667 19.1 19 1 decreased circulating HDL cholesterol level 1.31379171697536e-07 5.10633889996282e-06 1.58848512809379 0.40625 19.1 19 1 abnormal tooth morphology 0.000170818834597145 0.00242806772034514 1.58848512809379 0.40625 19.1 19 1 polydipsia 0.00707096074145947 0.0437132060021873 1.58848512809379 0.40625 19.1 19 1 failure of primitive streak formation 0.00707096074145947 0.0437132060021873 1.58848512809379 0.40625 19.1 19 1 abnormal long term potentiation 0.00707096074145947 0.0437132060021873 1.58848512809379 0.40625 19.1 19 1 abnormal heart atrium morphology 0.00707096074145947 0.0437132060021873 1.58848512809379 0.40625 19.1 19 1 decreased spleen weight 9.98933442498464e-05 0.00155302933638433 1.58671424166336 0.405797101449275 19.1 19 1 abnormal humerus morphology 0.00402355663627582 0.0292278010342777 1.58518266421002 0.405405405405405 19.1 19 1 abnormal optic nerve morphology 0.00230527716419417 0.0183206931179968 1.58266650125096 0.404761904761905 19.1 19 1 spina bifida 0.00230527716419417 0.0183206931179968 1.58266650125096 0.404761904761905 19.1 19 1 liver hypoplasia 0.000768291937854938 0.00775304744589922 1.57908580780921 0.403846153846154 19.1 19 1 abnormal circulating amino acid level 0.000446093127228999 0.00497603880709478 1.57776660496225 0.403508771929825 19.1 19 1 pericardial effusion 0.000259789711470566 0.00339757692352149 1.57666017676803 0.403225806451613 19.1 19 1 female infertility 9.3252493551632e-14 1.32551758691248e-11 1.57286670867355 0.402255639097744 19.1 19 1 kinked tail 3.67654800602655e-06 9.37991093845235e-05 1.57171379189974 0.401960784313726 19.1 19 1 decreased body weight 3.15764128787472e-59 1.57092654071767e-55 1.56973204158094 0.401453957996769 19.1 19 1 increased or absent threshold for auditory brainstem response 1.0416974429917e-14 1.787049923753e-12 1.56945882232743 0.401384083044983 19.1 19 1 abnormal rostral-caudal axis patterning 0.000678674049824379 0.00715339702939891 1.56404689535389 0.4 19.1 19 1 abnormal erythropoiesis 3.26764535015494e-06 8.466945633865e-05 1.56404689535389 0.4 19.1 19 1 decreased heart rate 5.53705046899437e-06 0.000129937858883241 1.56404689535389 0.4 19.1 19 1 absent mesoderm 0.000394500761172345 0.00460713917096812 1.56404689535389 0.4 19.1 19 1 abnormal axon extension 0.00117145119342326 0.0107925364579273 1.56404689535389 0.4 19.1 19 1 decreased respiratory quotient 0.00117145119342326 0.0107925364579273 1.56404689535389 0.4 19.1 19 1 abnormal metabolism 0.00203019660566942 0.0164498829205299 1.56404689535389 0.4 19.1 19 1 thick pulmonary interalveolar septum 0.0061969678524642 0.040442971007928 1.56404689535389 0.4 19.1 19 1 increased carcinoma incidence 0.0061969678524642 0.040442971007928 1.56404689535389 0.4 19.1 19 1 emphysema 0.0109485396995531 0.0591653287415945 1.56404689535389 0.4 19.1 19 1 abnormal spleen marginal zone morphology 0.0109485396995531 0.0591653287415945 1.56404689535389 0.4 19.1 19 1 enhanced paired-pulse facilitation 0.0109485396995531 0.0591653287415945 1.56404689535389 0.4 19.1 19 1 abnormal synaptic transmission 0.0109485396995531 0.0591653287415945 1.56404689535389 0.4 19.1 19 1 abnormal microglial cell physiology 0.0109485396995531 0.0591653287415945 1.56404689535389 0.4 19.1 19 1 liver hemorrhage 0.0109485396995531 0.0591653287415945 1.56404689535389 0.4 19.1 19 1 abnormal fat pad morphology 0.0109485396995531 0.0591653287415945 1.56404689535389 0.4 19.1 19 1 spontaneous skin ulceration 0.0195542133999824 0.0901596030258686 1.56404689535389 0.4 19.1 19 1 abnormal nest building behavior 0.0195542133999824 0.0901596030258686 1.56404689535389 0.4 19.1 19 1 abnormal primitive streak morphology 0.0195542133999824 0.0901596030258686 1.56404689535389 0.4 19.1 19 1 abnormal cochlear outer hair cell morphology 0.0195542133999824 0.0901596030258686 1.56404689535389 0.4 19.1 19 1 abnormal vertebrae development 0.0195542133999824 0.0901596030258686 1.56404689535389 0.4 19.1 19 1 abnormal cell proliferation 0.035464359173176 0.137544350610189 1.56404689535389 0.4 19.1 19 1 waved hair 0.035464359173176 0.137544350610189 1.56404689535389 0.4 19.1 19 1 abnormal hair texture 0.035464359173176 0.137544350610189 1.56404689535389 0.4 19.1 19 1 abnormal trachea morphology 0.035464359173176 0.137544350610189 1.56404689535389 0.4 19.1 19 1 abnormal Peyer's patch T cell area morphology 0.035464359173176 0.137544350610189 1.56404689535389 0.4 19.1 19 1 abnormal lens epithelium morphology 0.035464359173176 0.137544350610189 1.56404689535389 0.4 19.1 19 1 decreased circulating VLDL cholesterol level 0.035464359173176 0.137544350610189 1.56404689535389 0.4 19.1 19 1 decreased muscle cell glucose uptake 0.035464359173176 0.137544350610189 1.56404689535389 0.4 19.1 19 1 decreased hepatocyte number 0.0658499104837901 0.208797517308385 1.56404689535389 0.4 19.1 19 1 hyperpigmentation 0.0658499104837901 0.208797517308385 1.56404689535389 0.4 19.1 19 1 abnormal pup retrieval 0.0658499104837901 0.208797517308385 1.56404689535389 0.4 19.1 19 1 audiogenic seizures 0.0658499104837901 0.208797517308385 1.56404689535389 0.4 19.1 19 1 abnormal apical ectodermal ridge morphology 0.0658499104837901 0.208797517308385 1.56404689535389 0.4 19.1 19 1 abnormal lymph node B cell domain morphology 0.0658499104837901 0.208797517308385 1.56404689535389 0.4 19.1 19 1 dilated ureter 0.0658499104837901 0.208797517308385 1.56404689535389 0.4 19.1 19 1 abnormal glial cell morphology 0.0658499104837901 0.208797517308385 1.56404689535389 0.4 19.1 19 1 abnormal rostral migratory stream morphology 0.0658499104837901 0.208797517308385 1.56404689535389 0.4 19.1 19 1 abnormal energy homeostasis 0.0658499104837901 0.208797517308385 1.56404689535389 0.4 19.1 19 1 ostium primum atrial septal defect 0.0658499104837901 0.208797517308385 1.56404689535389 0.4 19.1 19 1 herniated liver 0.0658499104837901 0.208797517308385 1.56404689535389 0.4 19.1 19 1 short tail 4.08561101660234e-05 0.000736446188681037 1.55462492610477 0.397590361445783 19.1 19 1 abnormal lipid level 4.08561101660234e-05 0.000736446188681037 1.55462492610477 0.397590361445783 19.1 19 1 abnormal fertility/fecundity 0.000118792701706283 0.00180181003350231 1.55333424538571 0.397260273972603 19.1 19 1 astrocytosis 0.000118792701706283 0.00180181003350231 1.55333424538571 0.397260273972603 19.1 19 1 cataract 8.98575979186627e-07 2.79400968528342e-05 1.55112088795427 0.396694214876033 19.1 19 1 enlarged kidney 0.00103072357363849 0.00988025005559051 1.54929173596376 0.39622641509434 19.1 19 1 postnatal lethality, incomplete penetrance 2.94614896216787e-26 1.46570910867851e-23 1.54890207506437 0.39612676056338 19.1 19 1 cyanosis 7.9922705625728e-10 5.37318189848644e-08 1.54775474019395 0.395833333333333 19.1 19 1 oligodactyly 0.00178297664068762 0.014808528860469 1.54775474019395 0.395833333333333 19.1 19 1 small heart 0.00178297664068762 0.014808528860469 1.54775474019395 0.395833333333333 19.1 19 1 decreased heart weight 6.14845173202191e-05 0.00104042678118398 1.54473767442359 0.395061728395062 19.1 19 1 decreased total retina thickness 0.00541363141437841 0.0358626049088317 1.54346733094134 0.394736842105263 19.1 19 1 abnormal skeletal muscle fiber morphology 0.000179079518644149 0.00248167299513827 1.54201806584186 0.394366197183099 19.1 19 1 increased mean corpuscular hemoglobin 1.10573078050373e-05 0.000231134900546473 1.54034921512125 0.393939393939394 19.1 19 1 abnormal ovarian folliculogenesis 0.00952722308806212 0.0533760527737715 1.54034921512125 0.393939393939394 19.1 19 1 dilated heart atrium 0.00952722308806212 0.0533760527737715 1.54034921512125 0.393939393939394 19.1 19 1 abnormal locomotor coordination 0.00952722308806212 0.0533760527737715 1.54034921512125 0.393939393939394 19.1 19 1 abnormal QRS complex 0.00952722308806212 0.0533760527737715 1.54034921512125 0.393939393939394 19.1 19 1 head tossing 0.00952722308806212 0.0533760527737715 1.54034921512125 0.393939393939394 19.1 19 1 cardiovascular system phenotype 0.00952722308806212 0.0533760527737715 1.54034921512125 0.393939393939394 19.1 19 1 perinatal lethality, incomplete penetrance 4.1465843659378e-11 3.68379593223938e-09 1.53982493016035 0.393805309734513 19.1 19 1 increased startle reflex 3.18782450847503e-05 0.000596219057506137 1.53768655442096 0.393258426966292 19.1 19 1 hydronephrosis 5.42270833645889e-05 0.000933493909130899 1.53611748650828 0.392857142857143 19.1 19 1 abnormal coat/hair pigmentation 3.40341821503528e-06 8.77305990663239e-05 1.53611748650828 0.392857142857143 19.1 19 1 abnormal seminal vesicle morphology 0.000904955146531438 0.00891515218612654 1.53611748650828 0.392857142857143 19.1 19 1 enhanced long term potentiation 0.000904955146531438 0.00891515218612654 1.53611748650828 0.392857142857143 19.1 19 1 abnormal stria vascularis morphology 0.0169243422755552 0.0817462163309586 1.53611748650828 0.392857142857143 19.1 19 1 abnormal retinal inner nuclear layer morphology 0.0169243422755552 0.0817462163309586 1.53611748650828 0.392857142857143 19.1 19 1 enhanced coordination 0.0169243422755552 0.0817462163309586 1.53611748650828 0.392857142857143 19.1 19 1 increased bone resorption 0.0169243422755552 0.0817462163309586 1.53611748650828 0.392857142857143 19.1 19 1 decreased circulating progesterone level 0.0169243422755552 0.0817462163309586 1.53611748650828 0.392857142857143 19.1 19 1 increased triglyceride level 0.0169243422755552 0.0817462163309586 1.53611748650828 0.392857142857143 19.1 19 1 subcutaneous edema 0.0169243422755552 0.0817462163309586 1.53611748650828 0.392857142857143 19.1 19 1 embryonic lethality before implantation, complete penetrance 1.05185725979641e-06 3.19084748017509e-05 1.53276595744681 0.392 19.1 19 1 pale liver 0.000157628429658751 0.00227304764507909 1.53234324206969 0.391891891891892 19.1 19 1 decreased litter size 3.55232506766199e-13 4.53149159272266e-11 1.53065087623601 0.391459074733096 19.1 19 1 abnormal testis morphology 3.00475663334836e-06 7.95141715473834e-05 1.53004587588967 0.391304347826087 19.1 19 1 abnormal inner ear morphology 0.0027082162431631 0.0209539281644423 1.53004587588967 0.391304347826087 19.1 19 1 embryonic lethality between implantation and placentation, complete penetrance 0.0027082162431631 0.0209539281644423 1.53004587588967 0.391304347826087 19.1 19 1 fragile skeleton 0.030454140411887 0.124699052303817 1.53004587588967 0.391304347826087 19.1 19 1 abnormal hepatocyte physiology 0.030454140411887 0.124699052303817 1.53004587588967 0.391304347826087 19.1 19 1 thymus hypoplasia 3.26123771879908e-07 1.13459144412765e-05 1.53004587588967 0.391304347826087 19.1 19 1 decreased anxiety-related response 1.56836497919049e-06 4.58977398321923e-05 1.52589941010135 0.390243902439024 19.1 19 1 abnormal developmental patterning 8.12856935067645e-05 0.00130872597150859 1.52589941010135 0.390243902439024 19.1 19 1 Leydig cell hyperplasia 0.00471791204175703 0.0330121130910565 1.52589941010135 0.390243902439024 19.1 19 1 liver fibrosis 0.00471791204175703 0.0330121130910565 1.52589941010135 0.390243902439024 19.1 19 1 abnormal glucose homeostasis 5.85471278511272e-09 3.09863788361019e-07 1.52537540618305 0.39010989010989 19.1 19 1 alopecia 2.47431059432747e-05 0.000480847469014811 1.52288776652878 0.389473684210526 19.1 19 1 abnormal osteoblast physiology 0.0013664923683457 0.0122052056239136 1.52060114826072 0.388888888888889 19.1 19 1 increased circulating alkaline phosphatase level 4.69077900766195e-08 2.02927178809723e-06 1.52060114826072 0.388888888888889 19.1 19 1 cochlear outer hair cell degeneration 0.000236564430113381 0.00313007457397359 1.52060114826072 0.388888888888889 19.1 19 1 impaired wound healing 0.00827036953292225 0.0477945559345937 1.52060114826072 0.388888888888889 19.1 19 1 decreased cellular sensitivity to gamma-irradiation 0.0558404597347902 0.191326644063761 1.52060114826072 0.388888888888889 19.1 19 1 abnormal body wall morphology 0.0558404597347902 0.191326644063761 1.52060114826072 0.388888888888889 19.1 19 1 long tibia 0.0558404597347902 0.191326644063761 1.52060114826072 0.388888888888889 19.1 19 1 absent inner cell mass 0.0558404597347902 0.191326644063761 1.52060114826072 0.388888888888889 19.1 19 1 increased effector memory CD8-positive, alpha-beta T cell number 0.0558404597347902 0.191326644063761 1.52060114826072 0.388888888888889 19.1 19 1 decreased fluid intake 0.0558404597347902 0.191326644063761 1.52060114826072 0.388888888888889 19.1 19 1 increased adipocyte glucose uptake 0.0558404597347902 0.191326644063761 1.52060114826072 0.388888888888889 19.1 19 1 embryonic lethality, complete penetrance 2.12599139002269e-14 3.52560238845429e-12 1.51992018043795 0.38871473354232 19.1 19 1 postnatal lethality, complete penetrance 4.29163625290375e-17 1.06754451790981e-14 1.51947561077126 0.38860103626943 19.1 19 1 abnormal eye electrophysiology 2.33531399348176e-06 6.38361929536909e-05 1.51880586945522 0.388429752066116 19.1 19 1 decreased neuronal precursor cell number 0.0146147880804346 0.0724910974079382 1.51359376969731 0.387096774193548 19.1 19 1 embryonic lethality during organogenesis, incomplete penetrance 1.23017590318759e-10 1.02002085305971e-08 1.51304536615756 0.38695652173913 19.1 19 1 insulin resistance 1.07231572966266e-06 3.21721509684859e-05 1.51072711483046 0.386363636363636 19.1 19 1 abnormal vertebrae morphology 9.92142262345162e-06 0.000211474127601103 1.50665067901062 0.385321100917431 19.1 19 1 decreased startle reflex 5.15521507012122e-06 0.000121550687079872 1.50389124553258 0.384615384615385 19.1 19 1 abnormal locomotor activation 5.50008113315013e-05 0.000943548401290411 1.50389124553258 0.384615384615385 19.1 19 1 small liver 0.000181637779829772 0.00249701321811586 1.50389124553258 0.384615384615385 19.1 19 1 increased embryonic tissue cell apoptosis 0.000181637779829772 0.00249701321811586 1.50389124553258 0.384615384615385 19.1 19 1 increased vascular permeability 0.00716680644684111 0.0437132060021873 1.50389124553258 0.384615384615385 19.1 19 1 decreased trabecular bone volume 0.00716680644684111 0.0437132060021873 1.50389124553258 0.384615384615385 19.1 19 1 abnormal kidney cortex morphology 0.0261052999981987 0.113032086589242 1.50389124553258 0.384615384615385 19.1 19 1 abnormal Schwann cell morphology 0.0261052999981987 0.113032086589242 1.50389124553258 0.384615384615385 19.1 19 1 abnormal nerve conduction 0.0261052999981987 0.113032086589242 1.50389124553258 0.384615384615385 19.1 19 1 short premaxilla 0.105529272052649 0.285618143663744 1.50389124553258 0.384615384615385 19.1 19 1 absent myocardial trabeculae 0.105529272052649 0.285618143663744 1.50389124553258 0.384615384615385 19.1 19 1 absent trabeculae carneae 0.105529272052649 0.285618143663744 1.50389124553258 0.384615384615385 19.1 19 1 abnormal renal/urinary system morphology 0.105529272052649 0.285618143663744 1.50389124553258 0.384615384615385 19.1 19 1 abnormal sympathetic ganglion morphology 0.105529272052649 0.285618143663744 1.50389124553258 0.384615384615385 19.1 19 1 abnormal grip strength 0.105529272052649 0.285618143663744 1.50389124553258 0.384615384615385 19.1 19 1 increased circulating adrenocorticotropin level 0.105529272052649 0.285618143663744 1.50389124553258 0.384615384615385 19.1 19 1 lymphoid hypoplasia 0.105529272052649 0.285618143663744 1.50389124553258 0.384615384615385 19.1 19 1 abnormal bile duct development 0.105529272052649 0.285618143663744 1.50389124553258 0.384615384615385 19.1 19 1 abnormal coping response 0.105529272052649 0.285618143663744 1.50389124553258 0.384615384615385 19.1 19 1 axonal dystrophy 0.105529272052649 0.285618143663744 1.50389124553258 0.384615384615385 19.1 19 1 abnormal afterhyperpolarization 0.105529272052649 0.285618143663744 1.50389124553258 0.384615384615385 19.1 19 1 vestibular hair cell degeneration 0.105529272052649 0.285618143663744 1.50389124553258 0.384615384615385 19.1 19 1 decreased endocochlear potential 0.105529272052649 0.285618143663744 1.50389124553258 0.384615384615385 19.1 19 1 abnormal exocrine pancreas morphology 0.105529272052649 0.285618143663744 1.50389124553258 0.384615384615385 19.1 19 1 abnormal vertebral arch development 0.105529272052649 0.285618143663744 1.50389124553258 0.384615384615385 19.1 19 1 increased renin activity 0.105529272052649 0.285618143663744 1.50389124553258 0.384615384615385 19.1 19 1 empty decidua capsularis 0.105529272052649 0.285618143663744 1.50389124553258 0.384615384615385 19.1 19 1 decreased cardiac stroke volume 0.105529272052649 0.285618143663744 1.50389124553258 0.384615384615385 19.1 19 1 embryonic growth arrest 2.36853535824767e-10 1.84116615738784e-08 1.50257780339675 0.384279475982533 19.1 19 1 small testis 3.81192021131816e-12 4.12267457637127e-10 1.50171169300283 0.384057971014493 19.1 19 1 abnormal neuron differentiation 8.7104379419557e-06 0.000190900567230086 1.50120572545127 0.383928571428571 19.1 19 1 anemia 1.27074386117517e-09 8.00246925233732e-08 1.50104026686807 0.383886255924171 19.1 19 1 preweaning lethality, complete penetrance 4.15542882295919e-30 2.58415729927775e-27 1.50063958878549 0.383783783783784 19.1 19 1 seminiferous tubule degeneration 0.000309844616677799 0.00382500488330533 1.49977099554482 0.383561643835616 19.1 19 1 abnormal long bone epiphyseal plate morphology 0.00104089024574836 0.00995145072286481 1.49887827471414 0.383333333333333 19.1 19 1 premature death 1.06455007228056e-34 8.82689434932632e-32 1.49865120634954 0.383275261324042 19.1 19 1 decreased lymphocyte cell number 2.35483236347765e-06 6.40179836519197e-05 1.49684175531915 0.3828125 19.1 19 1 abnormal nervous system physiology 7.64162767404727e-06 0.000170480258647467 1.49604485642546 0.382608695652174 19.1 19 1 abnormal bone remodeling 0.0126016795282968 0.0647503588088 1.49504482644121 0.382352941176471 19.1 19 1 increased width of hypertrophic chondrocyte zone 0.0126016795282968 0.0647503588088 1.49504482644121 0.382352941176471 19.1 19 1 abnormal gait 3.74701208128763e-13 4.66034627610149e-11 1.49318392922135 0.381877022653722 19.1 19 1 arrest of spermatogenesis 0.000138915547116094 0.00203865736549429 1.48956847176561 0.380952380952381 19.1 19 1 disheveled coat 0.00620261042794955 0.040442971007928 1.48956847176561 0.380952380952381 19.1 19 1 skin edema 0.00620261042794955 0.040442971007928 1.48956847176561 0.380952380952381 19.1 19 1 abnormal muscle morphology 0.00620261042794955 0.040442971007928 1.48956847176561 0.380952380952381 19.1 19 1 abnormal spleen white pulp morphology 0.00620261042794955 0.040442971007928 1.48956847176561 0.380952380952381 19.1 19 1 small ears 0.0473391489954495 0.166741316403395 1.48956847176561 0.380952380952381 19.1 19 1 decreased cochlear outer hair cell number 0.0473391489954495 0.166741316403395 1.48956847176561 0.380952380952381 19.1 19 1 abnormal hair follicle morphology 0.000906927108543319 0.00891692166996642 1.48956847176561 0.380952380952381 19.1 19 1 abnormal liver physiology 3.69175246269376e-05 0.000680239574144499 1.48584455058619 0.38 19.1 19 1 decreased double-positive T cell number 3.69175246269376e-05 0.000680239574144499 1.48584455058619 0.38 19.1 19 1 abnormal interventricular septum morphology 0.00309322333240479 0.0230716432964225 1.48584455058619 0.38 19.1 19 1 abnormal heart development 2.56817438629048e-07 9.39460850867288e-06 1.48485464748787 0.379746835443038 19.1 19 1 abnormal visceral yolk sac morphology 0.000236286864394442 0.00313007457397359 1.48485464748787 0.379746835443038 19.1 19 1 increased leukocyte cell number 8.27259326950794e-07 2.60481971619e-05 1.483147918008 0.379310344827586 19.1 19 1 abnormal spermiogenesis 0.00155719244069493 0.0137358730362718 1.483147918008 0.379310344827586 19.1 19 1 glomerulosclerosis 0.00155719244069493 0.0137358730362718 1.483147918008 0.379310344827586 19.1 19 1 abnormal parietal bone morphology 0.0223577048189615 0.0989409248948366 1.483147918008 0.379310344827586 19.1 19 1 lordosis 0.0223577048189615 0.0989409248948366 1.483147918008 0.379310344827586 19.1 19 1 increased retinal apoptosis 0.0223577048189615 0.0989409248948366 1.483147918008 0.379310344827586 19.1 19 1 abnormal vascular development 0.000789504738822509 0.0079349213649333 1.48110501453966 0.378787878787879 19.1 19 1 impaired swimming 0.000789504738822509 0.0079349213649333 1.48110501453966 0.378787878787879 19.1 19 1 small seminiferous tubules 0.000402497947906782 0.00468952527127925 1.47950381992935 0.378378378378378 19.1 19 1 abnormal branching of the mammary ductal tree 0.0108553860787071 0.0591653287415945 1.47950381992935 0.378378378378378 19.1 19 1 abnormal bone structure 1.6805015923754e-08 8.11698584666758e-07 1.4789562611507 0.378238341968912 19.1 19 1 abnormal lung morphology 8.66182637471876e-06 0.000190675160239937 1.47861576241439 0.378151260504202 19.1 19 1 sparse hair 0.000206102457104695 0.00277124249755637 1.47821505353569 0.378048780487805 19.1 19 1 oxidative stress 0.000105914526298814 0.00164151018173395 1.47715540116756 0.377777777777778 19.1 19 1 increased circulating corticosterone level 0.0053631373048349 0.0356667497726545 1.47715540116756 0.377777777777778 19.1 19 1 cardiomyopathy 0.0053631373048349 0.0356667497726545 1.47715540116756 0.377777777777778 19.1 19 1 respiratory failure 6.34644242259042e-07 2.09096364585347e-05 1.47600452044986 0.377483443708609 19.1 19 1 abnormal coat/ hair morphology 0.00268159087593606 0.0209539281644423 1.4755159390131 0.377358490566038 19.1 19 1 hypoglycemia 9.23941919366313e-05 0.00146048435749379 1.47154949831683 0.376344086021505 19.1 19 1 decreased erythrocyte cell number 4.86039481361945e-07 1.63381514849708e-05 1.46940711506177 0.375796178343949 19.1 19 1 thymus atrophy 0.00463411215021566 0.032701713400458 1.46629396439427 0.375 19.1 19 1 impaired glucose tolerance 3.41222836121469e-10 2.49644648485928e-08 1.46629396439427 0.375 19.1 19 1 hyperglycemia 0.000156514755394935 0.00226354915142384 1.46629396439427 0.375 19.1 19 1 abnormal osteoclast physiology 0.0011740555092909 0.0107965363377491 1.46629396439427 0.375 19.1 19 1 kidney cortex cysts 0.0191410844838197 0.0887482714883533 1.46629396439427 0.375 19.1 19 1 abnormal embryonic hematopoiesis 0.0191410844838197 0.0887482714883533 1.46629396439427 0.375 19.1 19 1 pancreatic islet hyperplasia 0.0191410844838197 0.0887482714883533 1.46629396439427 0.375 19.1 19 1 abnormal tympanic ring morphology 0.0878210792765669 0.265760261192774 1.46629396439427 0.375 19.1 19 1 abnormal hair follicle orientation 0.0878210792765669 0.265760261192774 1.46629396439427 0.375 19.1 19 1 abnormal pituitary gland morphology 0.0878210792765669 0.265760261192774 1.46629396439427 0.375 19.1 19 1 reduced male mating frequency 0.0878210792765669 0.265760261192774 1.46629396439427 0.375 19.1 19 1 impaired muscle relaxation 0.0878210792765669 0.265760261192774 1.46629396439427 0.375 19.1 19 1 decreased aggression towards mice 0.0878210792765669 0.265760261192774 1.46629396439427 0.375 19.1 19 1 abnormal molar crown morphology 0.0878210792765669 0.265760261192774 1.46629396439427 0.375 19.1 19 1 abnormal amnion morphology 0.0878210792765669 0.265760261192774 1.46629396439427 0.375 19.1 19 1 abnormal level of surface class II molecules 0.0878210792765669 0.265760261192774 1.46629396439427 0.375 19.1 19 1 loose skin 0.0878210792765669 0.265760261192774 1.46629396439427 0.375 19.1 19 1 decreased circulating triiodothyronine level 0.0878210792765669 0.265760261192774 1.46629396439427 0.375 19.1 19 1 infertility 3.62523018328667e-05 0.000672967170218328 1.46172607042419 0.373831775700935 19.1 19 1 cochlear inner hair cell degeneration 0.00400218456425594 0.0291520764380282 1.45671034371195 0.372549019607843 19.1 19 1 improved glucose tolerance 3.53824242792309e-08 1.59590009844992e-06 1.45631917552084 0.372448979591837 19.1 19 1 abnormal heart ventricle morphology 0.000450482680436716 0.0050000579797729 1.45376153734816 0.371794871794872 19.1 19 1 abnormal liver development 0.0163862818821978 0.0798450072124722 1.45232925997147 0.371428571428571 19.1 19 1 impaired behavioral response to xenobiotic 0.0163862818821978 0.0798450072124722 1.45232925997147 0.371428571428571 19.1 19 1 impaired adaptive thermogenesis 0.0163862818821978 0.0798450072124722 1.45232925997147 0.371428571428571 19.1 19 1 decreased bone mineralization 0.0163862818821978 0.0798450072124722 1.45232925997147 0.371428571428571 19.1 19 1 azoospermia 7.9469913595896e-07 2.51823452318205e-05 1.45092400669622 0.371069182389937 19.1 19 1 abnormal muscle physiology 0.000200557564070998 0.0027039942581388 1.44981875131119 0.370786516853933 19.1 19 1 neurodegeneration 0.00345517823334216 0.0253532621104384 1.44819156977212 0.37037037037037 19.1 19 1 increased exploration in new environment 0.000391063288094896 0.0045777408429932 1.44819156977212 0.37037037037037 19.1 19 1 decreased bone mineral content 2.05897656844785e-08 9.57327890469914e-07 1.44749532382511 0.370192307692308 19.1 19 1 decreased bone marrow cell number 0.000765585377420661 0.00774143750542234 1.44620774570394 0.36986301369863 19.1 19 1 male infertility 3.62264813868233e-18 1.06015732293792e-15 1.44588828298123 0.369781312127237 19.1 19 1 abnormal allantois morphology 0.00691947034098733 0.0437132060021873 1.44504332722913 0.369565217391304 19.1 19 1 abnormal nervous system electrophysiology 0.000339364782414359 0.00414825501845562 1.44301945702293 0.369047619047619 19.1 19 1 increased food intake 0.000339364782414359 0.00414825501845562 1.44301945702293 0.369047619047619 19.1 19 1 decreased hemoglobin content 4.27233050764116e-06 0.00010634243740648 1.44202905245394 0.368794326241135 19.1 19 1 decreased hair follicle number 0.014029742966232 0.0703608581219802 1.44056950887858 0.368421052631579 19.1 19 1 increased grooming behavior 0.014029742966232 0.0703608581219802 1.44056950887858 0.368421052631579 19.1 19 1 abnormal reproductive system physiology 0.014029742966232 0.0703608581219802 1.44056950887858 0.368421052631579 19.1 19 1 abnormal retinal outer nuclear layer morphology 0.014029742966232 0.0703608581219802 1.44056950887858 0.368421052631579 19.1 19 1 small superior vagus ganglion 0.0733797269198197 0.230034115580405 1.44056950887858 0.368421052631579 19.1 19 1 flaky skin 0.0733797269198197 0.230034115580405 1.44056950887858 0.368421052631579 19.1 19 1 unresponsive to tactile stimuli 0.0733797269198197 0.230034115580405 1.44056950887858 0.368421052631579 19.1 19 1 increased malignant tumor incidence 0.0733797269198197 0.230034115580405 1.44056950887858 0.368421052631579 19.1 19 1 decreased germ cell number 0.0733797269198197 0.230034115580405 1.44056950887858 0.368421052631579 19.1 19 1 maternal imprinting 0.0733797269198197 0.230034115580405 1.44056950887858 0.368421052631579 19.1 19 1 oliguria 0.0733797269198197 0.230034115580405 1.44056950887858 0.368421052631579 19.1 19 1 increased circulating VLDL cholesterol level 0.0733797269198197 0.230034115580405 1.44056950887858 0.368421052631579 19.1 19 1 increased hepatocellular carcinoma incidence 0.00298216673703044 0.0222766959710607 1.44056950887858 0.368421052631579 19.1 19 1 increased sarcoma incidence 0.00595285150993273 0.0391649703835073 1.43636959777398 0.36734693877551 19.1 19 1 decreased B cell proliferation 0.000574716253741236 0.0062156812225275 1.4353594925716 0.367088607594937 19.1 19 1 decreased food intake 0.000574716253741236 0.0062156812225275 1.4353594925716 0.367088607594937 19.1 19 1 abnormal pulmonary alveolus morphology 0.000114083192831091 0.00174099351022907 1.43241918633896 0.366336633663366 19.1 19 1 decreased circulating glucose level 2.62649808336099e-10 2.01028122534168e-08 1.42950522693635 0.365591397849462 19.1 19 1 lethargy 0.000221421946960012 0.00296920265802172 1.42950522693635 0.365591397849462 19.1 19 1 increased blood urea nitrogen level 4.71114083621125e-06 0.000111609169810243 1.42921526644407 0.36551724137931 19.1 19 1 abnormal skin condition 0.00512120538701819 0.0342446193553971 1.42869668325595 0.365384615384615 19.1 19 1 abnormal female meiosis 0.00512120538701819 0.0342446193553971 1.42869668325595 0.365384615384615 19.1 19 1 decreased leukocyte cell number 9.0497814306595e-06 0.000196605513613673 1.42705008700172 0.364963503649635 19.1 19 1 abnormal joint morphology 0.00440595360680319 0.0313585396192358 1.42186081395808 0.363636363636364 19.1 19 1 osteoporosis 0.0102927219108682 0.0567697245083916 1.42186081395808 0.363636363636364 19.1 19 1 abnormal circadian rhythm 0.0102927219108682 0.0567697245083916 1.42186081395808 0.363636363636364 19.1 19 1 muscular atrophy 0.0102927219108682 0.0567697245083916 1.42186081395808 0.363636363636364 19.1 19 1 renal interstitial fibrosis 0.0102927219108682 0.0567697245083916 1.42186081395808 0.363636363636364 19.1 19 1 abnormal photoreceptor outer segment morphology 0.0102927219108682 0.0567697245083916 1.42186081395808 0.363636363636364 19.1 19 1 abnormal skeleton physiology 0.0246347195671097 0.10779043961862 1.42186081395808 0.363636363636364 19.1 19 1 decreased brown adipose tissue amount 0.0246347195671097 0.10779043961862 1.42186081395808 0.363636363636364 19.1 19 1 abnormal enterocyte morphology 0.0615256402254746 0.197095982048768 1.42186081395808 0.363636363636364 19.1 19 1 intracerebral hemorrhage 0.0615256402254746 0.197095982048768 1.42186081395808 0.363636363636364 19.1 19 1 increased coping response 0.0615256402254746 0.197095982048768 1.42186081395808 0.363636363636364 19.1 19 1 parakeratosis 0.0615256402254746 0.197095982048768 1.42186081395808 0.363636363636364 19.1 19 1 abnormal retinal layer morphology 0.0615256402254746 0.197095982048768 1.42186081395808 0.363636363636364 19.1 19 1 abnormal retinal outer plexiform layer morphology 0.0615256402254746 0.197095982048768 1.42186081395808 0.363636363636364 19.1 19 1 abnormal mesenteric lymph node morphology 0.0615256402254746 0.197095982048768 1.42186081395808 0.363636363636364 19.1 19 1 hypoactivity 4.17865959857763e-13 5.07044670803017e-11 1.42091793543423 0.363395225464191 19.1 19 1 abnormal enzyme/coenzyme level 0.0037909359322479 0.0277351562690195 1.41573210355309 0.362068965517241 19.1 19 1 abnormal lysosome morphology 0.0209735366883101 0.0938326060520286 1.41198678052781 0.361111111111111 19.1 19 1 abnormal myocardial fiber morphology 0.000242076220179742 0.00317764959206918 1.41086704477799 0.360824742268041 19.1 19 1 abnormal maternal nurturing 0.00326215522792026 0.0242227197894079 1.41020621712236 0.360655737704918 19.1 19 1 abnormal male meiosis 0.00326215522792026 0.0242227197894079 1.41020621712236 0.360655737704918 19.1 19 1 abnormal inner ear vestibule morphology 0.0517390372540317 0.180127159089438 1.4076422058185 0.36 19.1 19 1 ruffled hair 0.0517390372540317 0.180127159089438 1.4076422058185 0.36 19.1 19 1 abnormal thyroid gland morphology 0.0517390372540317 0.180127159089438 1.4076422058185 0.36 19.1 19 1 increased cellular sensitivity to ionizing radiation 0.0517390372540317 0.180127159089438 1.4076422058185 0.36 19.1 19 1 abnormal cell morphology 8.12808800559274e-05 0.00130872597150859 1.40627023485766 0.359649122807018 19.1 19 1 decreased caudal vertebrae number 0.00280752345432826 0.0215879894672073 1.40519838254451 0.359375 19.1 19 1 embryonic lethality between implantation and somite formation, complete penetrance 1.13266202088041e-08 5.69191268068691e-07 1.404450273379 0.359183673469388 19.1 19 1 abnormal heart looping 0.017872987417091 0.0843199188663634 1.40363182916374 0.358974358974359 19.1 19 1 abnormal response to injury 0.017872987417091 0.0843199188663634 1.40363182916374 0.358974358974359 19.1 19 1 abnormal spermatogenesis 7.59432978256715e-07 2.43753488182397e-05 1.40254205289887 0.358695652173913 19.1 19 1 increased circulating triglyceride level 1.07722039026938e-05 0.000227083535660601 1.40224894066211 0.358620689655172 19.1 19 1 thrombocytopenia 1.07722039026938e-05 0.000227083535660601 1.40224894066211 0.358620689655172 19.1 19 1 abnormal mesoderm development 0.00648451937850528 0.042060604834503 1.40174014206245 0.358490566037736 19.1 19 1 increased circulating bilirubin level 0.00648451937850528 0.042060604834503 1.40174014206245 0.358490566037736 19.1 19 1 impaired righting response 0.000351209151654028 0.00419034320631349 1.39941038005348 0.357894736842105 19.1 19 1 enlarged heart 3.56070172719479e-08 1.59590009844992e-06 1.39887814993936 0.357758620689655 19.1 19 1 abnormal pancreas morphology 0.0152440852438813 0.0754620140182185 1.39647044228026 0.357142857142857 19.1 19 1 abnormal reproductive system morphology 0.0152440852438813 0.0754620140182185 1.39647044228026 0.357142857142857 19.1 19 1 myoclonus 0.043619407759147 0.15589551264494 1.39647044228026 0.357142857142857 19.1 19 1 small superior cervical ganglion 0.043619407759147 0.15589551264494 1.39647044228026 0.357142857142857 19.1 19 1 corneal vascularization 0.043619407759147 0.15589551264494 1.39647044228026 0.357142857142857 19.1 19 1 abnormal renal tubule epithelium morphology 0.043619407759147 0.15589551264494 1.39647044228026 0.357142857142857 19.1 19 1 abnormal zigzag hair morphology 0.137790849320626 0.354268462723572 1.39647044228026 0.357142857142857 19.1 19 1 megacephaly 0.137790849320626 0.354268462723572 1.39647044228026 0.357142857142857 19.1 19 1 extended life span 0.137790849320626 0.354268462723572 1.39647044228026 0.357142857142857 19.1 19 1 absent visceral yolk sac blood islands 0.137790849320626 0.354268462723572 1.39647044228026 0.357142857142857 19.1 19 1 abnormal adrenal gland secretion 0.137790849320626 0.354268462723572 1.39647044228026 0.357142857142857 19.1 19 1 increased lactate dehydrogenase level 0.137790849320626 0.354268462723572 1.39647044228026 0.357142857142857 19.1 19 1 abnormal kidney medulla morphology 0.137790849320626 0.354268462723572 1.39647044228026 0.357142857142857 19.1 19 1 abnormal vascular endothelial cell migration 0.137790849320626 0.354268462723572 1.39647044228026 0.357142857142857 19.1 19 1 abnormal uterus development 0.137790849320626 0.354268462723572 1.39647044228026 0.357142857142857 19.1 19 1 skeletal muscle necrosis 0.137790849320626 0.354268462723572 1.39647044228026 0.357142857142857 19.1 19 1 increased lung compliance 0.137790849320626 0.354268462723572 1.39647044228026 0.357142857142857 19.1 19 1 decreased grip strength 1.11806104776328e-07 4.4857691230825e-06 1.39264449586305 0.356164383561644 19.1 19 1 abnormal thoracic vertebrae morphology 0.00477430115355155 0.0331282006366315 1.39173664417083 0.355932203389831 19.1 19 1 decreased osteoclast cell number 0.01301249272799 0.0657229962657363 1.39026390698123 0.355555555555556 19.1 19 1 abnormal heart morphology 6.34670954754986e-08 2.65335126042526e-06 1.38800698505431 0.354978354978355 19.1 19 1 pale kidney 0.0368545335138836 0.142353497074201 1.38746095555587 0.354838709677419 19.1 19 1 increased susceptibility to pharmacologically induced seizures 0.000438536999423106 0.00493520000065884 1.38483318859459 0.354166666666667 19.1 19 1 abnormal phalanx morphology 0.0111160643483839 0.0591653287415945 1.38483318859459 0.354166666666667 19.1 19 1 abnormal neuron morphology 0.000378560889644268 0.00444184062731188 1.38236468023702 0.353535353535354 19.1 19 1 circling 0.000986391523229052 0.0095102671086522 1.38004137825343 0.352941176470588 19.1 19 1 abnormal oocyte morphology 0.0311981959519167 0.127431054893913 1.38004137825343 0.352941176470588 19.1 19 1 abnormal interatrial septum morphology 0.113273111545656 0.298798372184325 1.38004137825343 0.352941176470588 19.1 19 1 increased aggression towards mice 0.113273111545656 0.298798372184325 1.38004137825343 0.352941176470588 19.1 19 1 absence seizures 0.113273111545656 0.298798372184325 1.38004137825343 0.352941176470588 19.1 19 1 abnormal duodenum morphology 0.113273111545656 0.298798372184325 1.38004137825343 0.352941176470588 19.1 19 1 abnormal ectoplacental cone morphology 0.113273111545656 0.298798372184325 1.38004137825343 0.352941176470588 19.1 19 1 abnormal tendon morphology 0.113273111545656 0.298798372184325 1.38004137825343 0.352941176470588 19.1 19 1 increased hepatoma incidence 0.113273111545656 0.298798372184325 1.38004137825343 0.352941176470588 19.1 19 1 common atrium 0.113273111545656 0.298798372184325 1.38004137825343 0.352941176470588 19.1 19 1 abnormal electroretinogram waveform feature 0.113273111545656 0.298798372184325 1.38004137825343 0.352941176470588 19.1 19 1 abnormal cell cytoskeleton morphology 0.113273111545656 0.298798372184325 1.38004137825343 0.352941176470588 19.1 19 1 abnormal liver morphology 2.77917273506508e-06 7.47372127402635e-05 1.37618651406836 0.35195530726257 19.1 19 1 diluted coat color 0.00812901885730808 0.0476908830366836 1.37578199128351 0.351851851851852 19.1 19 1 small ovary 0.000732675582102136 0.00742374953351961 1.37498628162979 0.351648351648352 19.1 19 1 increased thermal nociceptive threshold 0.000732675582102136 0.00742374953351961 1.37498628162979 0.351648351648352 19.1 19 1 increased circulating phosphate level 0.0264542016018452 0.114046493040884 1.37382497564868 0.351351351351351 19.1 19 1 abnormal chromosome morphology 0.0264542016018452 0.114046493040884 1.37382497564868 0.351351351351351 19.1 19 1 abnormal calcium ion homeostasis 0.0264542016018452 0.114046493040884 1.37382497564868 0.351351351351351 19.1 19 1 skin inflammation 0.0264542016018452 0.114046493040884 1.37382497564868 0.351351351351351 19.1 19 1 seizures 0.000181692218081998 0.00249701321811586 1.37197096083674 0.350877192982456 19.1 19 1 abnormal spleen morphology 4.57712712165217e-06 0.000110118711588327 1.37078822724981 0.350574712643678 19.1 19 1 abnormal social investigation 0.0016523548653801 0.0145237905570071 1.36854103343465 0.35 19.1 19 1 increased erythrocyte cell number 0.00595937338297789 0.0391649703835073 1.36854103343465 0.35 19.1 19 1 decreased circulating phosphate level 0.0224648053776346 0.0989409248948366 1.36854103343465 0.35 19.1 19 1 abnormal skin pigmentation 0.0224648053776346 0.0989409248948366 1.36854103343465 0.35 19.1 19 1 abnormal circulating enzyme level 0.0937956941680122 0.278089140933171 1.36854103343465 0.35 19.1 19 1 abnormal fibula morphology 0.0937956941680122 0.278089140933171 1.36854103343465 0.35 19.1 19 1 dilated vasculature 0.0937956941680122 0.278089140933171 1.36854103343465 0.35 19.1 19 1 enhanced behavioral response to xenobiotic 0.0937956941680122 0.278089140933171 1.36854103343465 0.35 19.1 19 1 nuclear cataracts 0.0937956941680122 0.278089140933171 1.36854103343465 0.35 19.1 19 1 abnormal blood circulation 0.0191021913547803 0.0887482714883533 1.36399438548304 0.348837209302326 19.1 19 1 increased bone mineral content 0.000301360008323558 0.00372951751594452 1.36316013815247 0.348623853211009 19.1 19 1 abnormal skin morphology 0.0043782454520568 0.0312059758223246 1.36261661337649 0.348484848484849 19.1 19 1 abnormal cell cycle 0.000224364908335536 0.00300057908325079 1.3600407785686 0.347826086956522 19.1 19 1 abnormal immune system morphology 0.0162621046677247 0.079666041089973 1.3600407785686 0.347826086956522 19.1 19 1 abnormal sleep pattern 0.0162621046677247 0.079666041089973 1.3600407785686 0.347826086956522 19.1 19 1 abnormal carpal bone morphology 0.0780971067927214 0.240280214158187 1.3600407785686 0.347826086956522 19.1 19 1 bidirectional circling 0.0780971067927214 0.240280214158187 1.3600407785686 0.347826086956522 19.1 19 1 abnormal circulating insulin level 0.0780971067927214 0.240280214158187 1.3600407785686 0.347826086956522 19.1 19 1 decreased epididymis weight 0.0780971067927214 0.240280214158187 1.3600407785686 0.347826086956522 19.1 19 1 dilated heart 0.0780971067927214 0.240280214158187 1.3600407785686 0.347826086956522 19.1 19 1 abnormal lens development 0.0780971067927214 0.240280214158187 1.3600407785686 0.347826086956522 19.1 19 1 no abnormal phenotype detected 2.09713502260928e-46 3.47774891249371e-43 1.35670926657498 0.346974063400576 19.1 19 1 increased circulating LDL cholesterol level 0.0138590211688111 0.0697860630716954 1.35657128678653 0.346938775510204 19.1 19 1 abnormal epidermis stratum corneum morphology 0.0138590211688111 0.0697860630716954 1.35657128678653 0.346938775510204 19.1 19 1 increased T cell derived lymphoma incidence 0.0138590211688111 0.0697860630716954 1.35657128678653 0.346938775510204 19.1 19 1 spleen hyperplasia 0.00276666082751083 0.0213067145771926 1.3555073093067 0.346666666666667 19.1 19 1 cachexia 0.000499340065348707 0.00550824129736101 1.35350212097932 0.346153846153846 19.1 19 1 abnormal hair growth 0.0118224347470023 0.0619774635050964 1.35350212097932 0.346153846153846 19.1 19 1 increased percent body fat/body weight 0.0118224347470023 0.0619774635050964 1.35350212097932 0.346153846153846 19.1 19 1 small seminal vesicle 0.065309839330649 0.208681085850982 1.35350212097932 0.346153846153846 19.1 19 1 thick skin 0.065309839330649 0.208681085850982 1.35350212097932 0.346153846153846 19.1 19 1 abnormal tectorial membrane morphology 0.065309839330649 0.208681085850982 1.35350212097932 0.346153846153846 19.1 19 1 decreased Peyer's patch number 0.065309839330649 0.208681085850982 1.35350212097932 0.346153846153846 19.1 19 1 decreased bone mineral density 4.32418782974331e-08 1.88709074148886e-06 1.35237137568193 0.345864661654135 19.1 19 1 increased circulating calcium level 0.0100939699617412 0.0564105953464826 1.35076777326017 0.345454545454545 19.1 19 1 abnormal platelet physiology 0.0100939699617412 0.0564105953464826 1.35076777326017 0.345454545454545 19.1 19 1 decreased exploration in new environment 0.00175445088945755 0.014620424078813 1.34992142753758 0.345238095238095 19.1 19 1 cochlear ganglion degeneration 0.00862511311103573 0.0487612928720486 1.34831628909818 0.344827586206897 19.1 19 1 decreased bone strength 0.0548097777276654 0.188704944079679 1.34831628909818 0.344827586206897 19.1 19 1 decreased B cell number 1.63067838249777e-06 4.7442251186704e-05 1.34766176662774 0.344660194174757 19.1 19 1 abnormal trabecular bone morphology 0.000237877777207275 0.00313910329338512 1.34718325019978 0.34453781512605 19.1 19 1 increased double-negative T cell number 0.00737541291438319 0.0447471698159224 1.34610593452589 0.344262295081967 19.1 19 1 abnormal enzyme/coenzyme activity 2.87913010931171e-05 0.000540515935616066 1.34488108836162 0.343949044585987 19.1 19 1 increased circulating follicle stimulating hormone level 0.0461330068153454 0.164288982753288 1.34410280069475 0.34375 19.1 19 1 abnormal lymphatic vessel morphology 0.0461330068153454 0.164288982753288 1.34410280069475 0.34375 19.1 19 1 abnormal depression-related behavior 0.0461330068153454 0.164288982753288 1.34410280069475 0.34375 19.1 19 1 increased fatty acid level 0.0461330068153454 0.164288982753288 1.34410280069475 0.34375 19.1 19 1 decreased white adipose tissue amount 0.00540363927485211 0.0358441405231857 1.34227905198281 0.343283582089552 19.1 19 1 increased circulating serum albumin level 0.0389261511187267 0.149044361151908 1.34061162458905 0.342857142857143 19.1 19 1 abnormal intestinal goblet cell morphology 0.0389261511187267 0.149044361151908 1.34061162458905 0.342857142857143 19.1 19 1 decreased hematocrit 6.31801487213512e-05 0.001058320673026 1.33908124602216 0.342465753424658 19.1 19 1 incomplete somite formation 0.0329149200923639 0.133239810788861 1.33767168681582 0.342105263157895 19.1 19 1 decreased neutrophil cell number 0.000337579643872382 0.00414681167472864 1.33679221825118 0.341880341880342 19.1 19 1 cardiac fibrosis 0.00215219591839731 0.017325525394865 1.33403999897831 0.341176470588235 19.1 19 1 increased monocyte cell number 0.00101022060539804 0.00972117507128677 1.3294398610508 0.34 19.1 19 1 testicular atrophy 0.0171032541916391 0.0825302517976763 1.3294398610508 0.34 19.1 19 1 abnormal pancreatic islet morphology 0.0145676483650864 0.0723293918326398 1.32796434511179 0.339622641509434 19.1 19 1 abnormal inhibitory postsynaptic currents 0.00661982964758912 0.0427709772685141 1.32253965415954 0.338235294117647 19.1 19 1 decreased mean corpuscular hemoglobin 0.00661982964758912 0.0427709772685141 1.32253965415954 0.338235294117647 19.1 19 1 increased anxiety-related response 0.000145584875203382 0.00211779167876265 1.32212597269123 0.338129496402878 19.1 19 1 increased circulating insulin level 5.18947795253608e-05 0.000905882554872526 1.31966456795484 0.3375 19.1 19 1 decreased cardiac muscle contractility 0.00105681394795722 0.00995766930130147 1.31590483984101 0.336538461538462 19.1 19 1 abnormal lens morphology 0.000319242610333226 0.00393126729308861 1.31355500976987 0.3359375 19.1 19 1 decreased T cell number 6.27603396384804e-05 0.001058320673026 1.31146789361972 0.335403726708075 19.1 19 1 abnormal cervical vertebrae morphology 0.0209034920724162 0.0938326060520286 1.30337241279491 0.333333333333333 19.1 19 1 abnormal cardiovascular system morphology 0.02459646551606 0.10779043961862 1.30337241279491 0.333333333333333 19.1 19 1 abnormal osteoclast morphology 0.02459646551606 0.10779043961862 1.30337241279491 0.333333333333333 19.1 19 1 abnormal cartilage development 0.0289819738574176 0.11995450910204 1.30337241279491 0.333333333333333 19.1 19 1 irregular heartbeat 0.0289819738574176 0.11995450910204 1.30337241279491 0.333333333333333 19.1 19 1 abnormal ectoderm development 0.0289819738574176 0.11995450910204 1.30337241279491 0.333333333333333 19.1 19 1 abnormal atrioventricular cushion morphology 0.0809220310956127 0.248204133600908 1.30337241279491 0.333333333333333 19.1 19 1 rectal prolapse 0.0809220310956127 0.248204133600908 1.30337241279491 0.333333333333333 19.1 19 1 abnormal fetal cardiomyocyte proliferation 0.0809220310956127 0.248204133600908 1.30337241279491 0.333333333333333 19.1 19 1 decreased bone ossification 0.0809220310956127 0.248204133600908 1.30337241279491 0.333333333333333 19.1 19 1 abnormal foregut morphology 0.0970694098557951 0.285618143663744 1.30337241279491 0.333333333333333 19.1 19 1 abnormal adrenal gland morphology 0.0970694098557951 0.285618143663744 1.30337241279491 0.333333333333333 19.1 19 1 decreased metastatic potential 0.0970694098557951 0.285618143663744 1.30337241279491 0.333333333333333 19.1 19 1 abnormal primitive streak formation 0.0970694098557951 0.285618143663744 1.30337241279491 0.333333333333333 19.1 19 1 abnormal impulse conducting system conduction 0.0970694098557951 0.285618143663744 1.30337241279491 0.333333333333333 19.1 19 1 abnormal tumor morphology 0.0970694098557951 0.285618143663744 1.30337241279491 0.333333333333333 19.1 19 1 abnormal retinal ganglion layer morphology 0.0970694098557951 0.285618143663744 1.30337241279491 0.333333333333333 19.1 19 1 decreased fatty acid level 0.0970694098557951 0.285618143663744 1.30337241279491 0.333333333333333 19.1 19 1 increased circulating total protein level 0.0970694098557951 0.285618143663744 1.30337241279491 0.333333333333333 19.1 19 1 enlarged spleen 1.66237971217731e-07 6.36179928314007e-06 1.30337241279491 0.333333333333333 19.1 19 1 abnormal hepatocyte morphology 0.000946222387811145 0.00926664641606388 1.30337241279491 0.333333333333333 19.1 19 1 spleen hypoplasia 0.00127889690539024 0.0116743341363604 1.30337241279491 0.333333333333333 19.1 19 1 increased circulating HDL cholesterol level 0.00127889690539024 0.0116743341363604 1.30337241279491 0.333333333333333 19.1 19 1 deafness 0.00173064676294946 0.0145550954682029 1.30337241279491 0.333333333333333 19.1 19 1 abnormal retinal pigmentation 0.00318293044869679 0.0237052080572852 1.30337241279491 0.333333333333333 19.1 19 1 increased urine protein level 0.00504992121092435 0.0340187021382457 1.30337241279491 0.333333333333333 19.1 19 1 heart right ventricle hypertrophy 0.0479024583339349 0.167945546308193 1.30337241279491 0.333333333333333 19.1 19 1 abnormal reflex 0.0479024583339349 0.167945546308193 1.30337241279491 0.333333333333333 19.1 19 1 abnormal pharyngeal arch morphology 0.0479024583339349 0.167945546308193 1.30337241279491 0.333333333333333 19.1 19 1 abnormal epidermis stratum basale morphology 0.0568821504394634 0.194493950815347 1.30337241279491 0.333333333333333 19.1 19 1 absent vibrissae 0.0568821504394634 0.194493950815347 1.30337241279491 0.333333333333333 19.1 19 1 decreased systemic arterial blood pressure 0.0568821504394634 0.194493950815347 1.30337241279491 0.333333333333333 19.1 19 1 disorganized myocardium 0.0677331611211361 0.214359081792399 1.30337241279491 0.333333333333333 19.1 19 1 abnormal salivary gland morphology 0.117023966754294 0.307713654652543 1.30337241279491 0.333333333333333 19.1 19 1 left pulmonary isomerism 0.117023966754294 0.307713654652543 1.30337241279491 0.333333333333333 19.1 19 1 dry skin 0.117023966754294 0.307713654652543 1.30337241279491 0.333333333333333 19.1 19 1 abnormal megakaryocyte differentiation 0.141989437451089 0.362647815556745 1.30337241279491 0.333333333333333 19.1 19 1 cortical renal glomerulopathies 0.141989437451089 0.362647815556745 1.30337241279491 0.333333333333333 19.1 19 1 abnormal mammary gland morphology 0.141989437451089 0.362647815556745 1.30337241279491 0.333333333333333 19.1 19 1 absent spleen 0.141989437451089 0.362647815556745 1.30337241279491 0.333333333333333 19.1 19 1 abnormal bile duct morphology 0.141989437451089 0.362647815556745 1.30337241279491 0.333333333333333 19.1 19 1 increased circulating renin level 0.141989437451089 0.362647815556745 1.30337241279491 0.333333333333333 19.1 19 1 decreased pulmonary respiratory rate 0.141989437451089 0.362647815556745 1.30337241279491 0.333333333333333 19.1 19 1 abnormal macrophage chemotaxis 0.141989437451089 0.362647815556745 1.30337241279491 0.333333333333333 19.1 19 1 abnormal fontanelle morphology 0.173761318739043 0.401591001274304 1.30337241279491 0.333333333333333 19.1 19 1 macrocytosis 0.173761318739043 0.401591001274304 1.30337241279491 0.333333333333333 19.1 19 1 abnormal enteric neuron morphology 0.173761318739043 0.401591001274304 1.30337241279491 0.333333333333333 19.1 19 1 no suckling reflex 0.173761318739043 0.401591001274304 1.30337241279491 0.333333333333333 19.1 19 1 abnormal bronchus morphology 0.173761318739043 0.401591001274304 1.30337241279491 0.333333333333333 19.1 19 1 altered righting response 0.173761318739043 0.401591001274304 1.30337241279491 0.333333333333333 19.1 19 1 greasy coat 0.173761318739043 0.401591001274304 1.30337241279491 0.333333333333333 19.1 19 1 abnormal trophectoderm morphology 0.173761318739043 0.401591001274304 1.30337241279491 0.333333333333333 19.1 19 1 liver vascular congestion 0.173761318739043 0.401591001274304 1.30337241279491 0.333333333333333 19.1 19 1 bicuspid aortic valve 0.173761318739043 0.401591001274304 1.30337241279491 0.333333333333333 19.1 19 1 lung inflammation 0.000344487931512278 0.00419034320631349 1.29378879211259 0.330882352941176 19.1 19 1 abnormal renal glomerulus morphology 0.00132473257121896 0.0120705943989273 1.29141486772339 0.330275229357798 19.1 19 1 enlarged liver 0.00208548352711658 0.0168429879016314 1.29033868866696 0.33 19.1 19 1 increased T cell number 0.00383867618829546 0.0280020733676978 1.28856136264951 0.329545454545455 19.1 19 1 teratozoospermia 0.00383867618829546 0.0280020733676978 1.28856136264951 0.329545454545455 19.1 19 1 increased osteoclast cell number 0.0156248938753321 0.0772702256757229 1.28200565192941 0.327868852459016 19.1 19 1 increased susceptibility to injury 0.0253142913447601 0.110666607592426 1.2783075587027 0.326923076923077 19.1 19 1 decreased urine osmolality 0.0298024991389687 0.122232014193214 1.27677297579909 0.326530612244898 19.1 19 1 decreased circulating creatinine level 0.0298024991389687 0.122232014193214 1.27677297579909 0.326530612244898 19.1 19 1 decreased rib number 0.00460487827570865 0.0325415758830263 1.27408314509165 0.325842696629214 19.1 19 1 increased circulating creatinine level 0.00536972775471722 0.0356667497726545 1.27306142645084 0.325581395348837 19.1 19 1 decreased oxygen consumption 0.041492751798069 0.149044361151908 1.27306142645084 0.325581395348837 19.1 19 1 impaired ovarian folliculogenesis 0.0490886291589172 0.171983049341981 1.27078810247503 0.325 19.1 19 1 increased brown adipose tissue amount 0.058197621565338 0.195513566910096 1.26814613136802 0.324324324324324 19.1 19 1 abnormal vocalization 0.058197621565338 0.195513566910096 1.26814613136802 0.324324324324324 19.1 19 1 abnormal pancreatic beta cell physiology 0.058197621565338 0.195513566910096 1.26814613136802 0.324324324324324 19.1 19 1 abnormal retinal photoreceptor morphology 0.0691657808465509 0.218140242733609 1.26503793006564 0.323529411764706 19.1 19 1 thin skin 0.0691657808465509 0.218140242733609 1.26503793006564 0.323529411764706 19.1 19 1 decreased osteoblast cell number 0.0691657808465509 0.218140242733609 1.26503793006564 0.323529411764706 19.1 19 1 abnormal definitive hematopoiesis 0.00471535238230452 0.0330121130910565 1.26132814141442 0.32258064516129 19.1 19 1 abnormal cranial ganglia morphology 0.0824372695055419 0.251765141675918 1.26132814141442 0.32258064516129 19.1 19 1 increased lung adenoma incidence 0.0824372695055419 0.251765141675918 1.26132814141442 0.32258064516129 19.1 19 1 inner cell mass degeneration 0.0824372695055419 0.251765141675918 1.26132814141442 0.32258064516129 19.1 19 1 abnormal intestine physiology 0.0824372695055419 0.251765141675918 1.26132814141442 0.32258064516129 19.1 19 1 decreased insulin secretion 0.00549546590404663 0.0363563070114787 1.25992666570174 0.322222222222222 19.1 19 1 lymphoid hyperplasia 0.0985916947813072 0.285618143663744 1.25682339805223 0.321428571428571 19.1 19 1 abnormal respiration 0.0985916947813072 0.285618143663744 1.25682339805223 0.321428571428571 19.1 19 1 increased total body fat amount 0.000938191214394015 0.00920611694597678 1.25473911381002 0.32089552238806 19.1 19 1 abnormal kidney morphology 0.000192653955255341 0.00260449300922642 1.25123751628311 0.32 19.1 19 1 kidney inflammation 0.0357786144083002 0.138628198349917 1.25123751628311 0.32 19.1 19 1 decreased placenta weight 0.118401349903684 0.311006713712158 1.25123751628311 0.32 19.1 19 1 hyperkeratosis 0.0162855002589955 0.079666041089973 1.24670404702121 0.318840579710145 19.1 19 1 abnormal coat appearance 0.0162855002589955 0.079666041089973 1.24670404702121 0.318840579710145 19.1 19 1 abnormal food intake 0.0162855002589955 0.079666041089973 1.24670404702121 0.318840579710145 19.1 19 1 abnormal B cell differentiation 0.0065253713551771 0.0422704719947996 1.246081317727 0.318681318681319 19.1 19 1 increased spleen weight 0.00267154369408506 0.0209539281644423 1.24570106709602 0.31858407079646 19.1 19 1 lethality, incomplete penetrance 0.0498152563460618 0.174160857569682 1.24412821221332 0.318181818181818 19.1 19 1 abnormal long bone epiphysis morphology 0.142923185801076 0.363890915742248 1.24412821221332 0.318181818181818 19.1 19 1 intestinal inflammation 0.142923185801076 0.363890915742248 1.24412821221332 0.318181818181818 19.1 19 1 abnormal oogenesis 0.142923185801076 0.363890915742248 1.24412821221332 0.318181818181818 19.1 19 1 abnormal channel response 0.142923185801076 0.363890915742248 1.24412821221332 0.318181818181818 19.1 19 1 prolonged PR interval 0.142923185801076 0.363890915742248 1.24412821221332 0.318181818181818 19.1 19 1 rough coat 0.142923185801076 0.363890915742248 1.24412821221332 0.318181818181818 19.1 19 1 hemopericardium 0.0589339932063398 0.195513566910096 1.23979327070735 0.317073170731707 19.1 19 1 abnormal T cell differentiation 0.00488576487353031 0.0335264555114666 1.23884902602288 0.316831683168317 19.1 19 1 liver inflammation 0.00233593653615125 0.0185052297250835 1.23820379215516 0.316666666666667 19.1 19 1 abnormal eye physiology 0.026213844335283 0.113403370059159 1.23820379215516 0.316666666666667 19.1 19 1 hunched posture 0.0120822667121889 0.0632729230454103 1.23737887290656 0.316455696202532 19.1 19 1 abnormal nail morphology 0.17365545769629 0.401591001274304 1.23477386475307 0.315789473684211 19.1 19 1 thin dermal layer 0.17365545769629 0.401591001274304 1.23477386475307 0.315789473684211 19.1 19 1 decreased grooming behavior 0.17365545769629 0.401591001274304 1.23477386475307 0.315789473684211 19.1 19 1 abnormal blastocyst morphology 0.17365545769629 0.401591001274304 1.23477386475307 0.315789473684211 19.1 19 1 decreased eye pigmentation 0.17365545769629 0.401591001274304 1.23477386475307 0.315789473684211 19.1 19 1 abnormal behavioral response to xenobiotic 0.17365545769629 0.401591001274304 1.23477386475307 0.315789473684211 19.1 19 1 decreased liver glycogen level 0.17365545769629 0.401591001274304 1.23477386475307 0.315789473684211 19.1 19 1 incomplete embryo turning 0.0307791401221446 0.12582269688387 1.23477386475307 0.315789473684211 19.1 19 1 increased macrophage cell number 0.0307791401221446 0.12582269688387 1.23477386475307 0.315789473684211 19.1 19 1 increased cell proliferation 0.0361792636642199 0.139853796992614 1.2309628343063 0.314814814814815 19.1 19 1 decreased platelet aggregation 0.0361792636642199 0.139853796992614 1.2309628343063 0.314814814814815 19.1 19 1 abnormal dermal layer morphology 0.0830256111384704 0.253251021099871 1.22889398920662 0.314285714285714 19.1 19 1 increased circulating cholesterol level 0.000424134611508601 0.00483960938590663 1.22191163699522 0.3125 19.1 19 1 abnormal crypts of Lieberkuhn morphology 0.0989392070919949 0.285618143663744 1.22191163699522 0.3125 19.1 19 1 abnormal mouth morphology 0.212825063949259 0.409278969133191 1.22191163699522 0.3125 19.1 19 1 large intestinal inflammation 0.212825063949259 0.409278969133191 1.22191163699522 0.3125 19.1 19 1 small epididymis 0.212825063949259 0.409278969133191 1.22191163699522 0.3125 19.1 19 1 increased thymus weight 0.212825063949259 0.409278969133191 1.22191163699522 0.3125 19.1 19 1 decreased circulating prolactin level 0.212825063949259 0.409278969133191 1.22191163699522 0.3125 19.1 19 1 abnormal Langerhans cell physiology 0.212825063949259 0.409278969133191 1.22191163699522 0.3125 19.1 19 1 decreased creatinine clearance 0.212825063949259 0.409278969133191 1.22191163699522 0.3125 19.1 19 1 decreased skeletal muscle weight 0.212825063949259 0.409278969133191 1.22191163699522 0.3125 19.1 19 1 increased heart left ventricle size 0.212825063949259 0.409278969133191 1.22191163699522 0.3125 19.1 19 1 embryonic lethality between somite formation and embryo turning, incomplete penetrance 0.212825063949259 0.409278969133191 1.22191163699522 0.3125 19.1 19 1 decreased adipocyte glucose uptake 0.212825063949259 0.409278969133191 1.22191163699522 0.3125 19.1 19 1 polyuria 0.0166359462708777 0.08090306226551 1.2187378405355 0.311688311688312 19.1 19 1 small placenta 0.0592238355344818 0.195513566910096 1.21648091860858 0.311111111111111 19.1 19 1 enlarged epididymis 0.118293557455446 0.310887717031614 1.21348466018836 0.310344827586207 19.1 19 1 increased circulating free fatty acid level 0.0227122235800015 0.0997293136015069 1.21158562316146 0.309859154929577 19.1 19 1 abnormal vibrissa morphology 0.070020389315323 0.220615222826936 1.21027438330955 0.30952380952381 19.1 19 1 increased heart weight 0.00209655574297026 0.0169049672954247 1.20960461331326 0.309352517985612 19.1 19 1 increased sensitivity to xenobiotic induced morbidity/mortality 0.00584249093994006 0.0384985330148368 1.20858169186437 0.309090909090909 19.1 19 1 weight loss 0.0006656246510676 0.00703074870289025 1.20655046213014 0.308571428571429 19.1 19 1 abnormal cardiovascular system physiology 0.00281265197873453 0.0215940487564881 1.20537448702085 0.308270676691729 19.1 19 1 increased grip strength 0.0123524885557803 0.064080949494272 1.20311299642607 0.307692307692308 19.1 19 1 absent corpus luteum 0.050251727661505 0.175440242186658 1.20311299642607 0.307692307692308 19.1 19 1 abnormal brain wave pattern 0.050251727661505 0.175440242186658 1.20311299642607 0.307692307692308 19.1 19 1 abnormal stomach morphology 0.141997576825033 0.362647815556745 1.20311299642607 0.307692307692308 19.1 19 1 pulmonary edema 0.141997576825033 0.362647815556745 1.20311299642607 0.307692307692308 19.1 19 1 increased circulating alanine transaminase level 0.0195019135403714 0.0901596030258686 1.20311299642607 0.307692307692308 19.1 19 1 abnormal circulating hormone level 0.0829468603852485 0.253166030930436 1.20311299642607 0.307692307692308 19.1 19 1 abnormal heart left ventricle morphology 0.026581445319646 0.11449583590064 1.194758045062 0.305555555555556 19.1 19 1 abnormal systemic arterial blood pressure 0.0984797983724661 0.285618143663744 1.194758045062 0.305555555555556 19.1 19 1 abnormal colon morphology 0.042692101359275 0.153021040534865 1.192917123575 0.305084745762712 19.1 19 1 increased B cell proliferation 0.042692101359275 0.153021040534865 1.192917123575 0.305084745762712 19.1 19 1 abnormal blood vessel physiology 0.171284595367231 0.401591001274304 1.19003568124752 0.304347826086957 19.1 19 1 abnormal cardiovascular development 0.171284595367231 0.401591001274304 1.19003568124752 0.304347826086957 19.1 19 1 kidney failure 0.0823823655727996 0.251765141675918 1.18212846741863 0.302325581395349 19.1 19 1 abnormal placenta development 0.058840974229053 0.195513566910096 1.18041275121048 0.30188679245283 19.1 19 1 small gonad 0.20788107063698 0.40784904770767 1.17303517151541 0.3 19.1 19 1 decreased myocardial infarction size 0.20788107063698 0.40784904770767 1.17303517151541 0.3 19.1 19 1 kidney atrophy 0.20788107063698 0.40784904770767 1.17303517151541 0.3 19.1 19 1 abnormal sperm mitochondrial sheath morphology 0.20788107063698 0.40784904770767 1.17303517151541 0.3 19.1 19 1 abnormal action potential 0.0361040341540341 0.13978021005161 1.17303517151541 0.3 19.1 19 1 increased circulating chloride level 0.0691910156851527 0.218140242733609 1.17303517151541 0.3 19.1 19 1 abnormal circulating protein level 0.0691910156851527 0.218140242733609 1.17303517151541 0.3 19.1 19 1 decreased oocyte number 0.0691910156851527 0.218140242733609 1.17303517151541 0.3 19.1 19 1 gastrointestinal hemorrhage 0.139962298741579 0.359479832854597 1.17303517151541 0.3 19.1 19 1 abnormal estrous cycle 0.139962298741579 0.359479832854597 1.17303517151541 0.3 19.1 19 1 increased B cell number 0.00908714373134044 0.0512568481444656 1.16969319096979 0.299145299145299 19.1 19 1 abnormal dendritic cell physiology 0.0122561291661625 0.0636474348660315 1.16938085633935 0.299065420560748 19.1 19 1 decreased IgM level 0.0165817527673326 0.0807184148899018 1.16900412281605 0.298969072164948 19.1 19 1 maternal effect 0.0421628302093999 0.151342049272557 1.16719917563723 0.298507462686567 19.1 19 1 abnormal blood homeostasis 0.0105173956285141 0.0579446769123562 1.16617531671123 0.298245614035088 19.1 19 1 hepatic necrosis 0.0814617424815487 0.249551828106961 1.16471577313587 0.297872340425532 19.1 19 1 decreased bone trabecula number 0.0814617424815487 0.249551828106961 1.16471577313587 0.297872340425532 19.1 19 1 increased white adipose tissue amount 0.115522257790866 0.304247343837777 1.16246728708735 0.297297297297297 19.1 19 1 decreased circulating chloride level 0.115522257790866 0.304247343837777 1.16246728708735 0.297297297297297 19.1 19 1 increased erythroid progenitor cell number 0.115522257790866 0.304247343837777 1.16246728708735 0.297297297297297 19.1 19 1 decreased eosinophil cell number 0.049266765781191 0.17236438801788 1.16081605514546 0.296875 19.1 19 1 increased sacral vertebrae number 0.049266765781191 0.17236438801788 1.16081605514546 0.296875 19.1 19 1 increased neutrophil cell number 0.00497129537691655 0.0340187021382457 1.15955200862443 0.296551724137931 19.1 19 1 thin epidermis 0.167713596079526 0.401591001274304 1.15855325581769 0.296296296296296 19.1 19 1 cryptorchism 0.167713596079526 0.401591001274304 1.15855325581769 0.296296296296296 19.1 19 1 cardiac hypertrophy 0.0190785928554058 0.0887482714883533 1.15707550931793 0.295918367346939 19.1 19 1 decreased macrophage cell number 0.0960395404098185 0.284233618999909 1.15526191134094 0.295454545454545 19.1 19 1 decreased blood urea nitrogen level 0.0960395404098185 0.284233618999909 1.15526191134094 0.295454545454545 19.1 19 1 increased kidney weight 0.0802794929151017 0.246842074939821 1.15003448187786 0.294117647058824 19.1 19 1 decreased pancreatic beta cell number 0.137249510168649 0.354268462723572 1.15003448187786 0.294117647058824 19.1 19 1 enlarged sebaceous gland 0.254305044117427 0.481785070252933 1.15003448187786 0.294117647058824 19.1 19 1 abnormal involuntary movement 0.254305044117427 0.481785070252933 1.15003448187786 0.294117647058824 19.1 19 1 dermatitis 0.0673944119087572 0.213422787553193 1.14606884573345 0.293103448275862 19.1 19 1 thrombocytosis 0.0673944119087572 0.213422787553193 1.14606884573345 0.293103448275862 19.1 19 1 increased bone mineral density 0.0159523158731125 0.0788110938120504 1.14189264483801 0.292035398230089 19.1 19 1 abnormal intestinal epithelium morphology 0.0943432538617174 0.279545972580134 1.14045086119554 0.291666666666667 19.1 19 1 decreased body height 0.201843789401352 0.401591001274304 1.14045086119554 0.291666666666667 19.1 19 1 prolonged QT interval 0.201843789401352 0.401591001274304 1.14045086119554 0.291666666666667 19.1 19 1 increased hemangiosarcoma incidence 0.201843789401352 0.401591001274304 1.14045086119554 0.291666666666667 19.1 19 1 increased body temperature 0.201843789401352 0.401591001274304 1.14045086119554 0.291666666666667 19.1 19 1 abnormal placenta labyrinth morphology 0.0406218917364848 0.149044361151908 1.13838856307403 0.291139240506329 19.1 19 1 abnormal retinal photoreceptor layer morphology 0.16349526524723 0.401591001274304 1.13519532727298 0.290322580645161 19.1 19 1 decreased double-negative T cell number 0.16349526524723 0.401591001274304 1.13519532727298 0.290322580645161 19.1 19 1 abnormal podocyte morphology 0.16349526524723 0.401591001274304 1.13519532727298 0.290322580645161 19.1 19 1 increased bone marrow cell number 0.1341227269733 0.346989374254898 1.13187604269031 0.289473684210526 19.1 19 1 hyporesponsive to tactile stimuli 0.1341227269733 0.346989374254898 1.13187604269031 0.289473684210526 19.1 19 1 abnormal ovarian follicle morphology 0.110995920515424 0.294352187934028 1.12958942442225 0.288888888888889 19.1 19 1 albuminuria 0.110995920515424 0.294352187934028 1.12958942442225 0.288888888888889 19.1 19 1 increased hemoglobin content 0.0773929661787856 0.239283874572255 1.12664395004305 0.288135593220339 19.1 19 1 abnormal humoral immune response 0.02787975007212 0.118754177820416 1.1171763538242 0.285714285714286 19.1 19 1 abnormal respiratory system physiology 0.108413637285565 0.287811016806664 1.1171763538242 0.285714285714286 19.1 19 1 abnormal anxiety-related response 0.244223912190055 0.463568852783488 1.1171763538242 0.285714285714286 19.1 19 1 hypoalgesia 0.244223912190055 0.463568852783488 1.1171763538242 0.285714285714286 19.1 19 1 increased acute inflammation 0.244223912190055 0.463568852783488 1.1171763538242 0.285714285714286 19.1 19 1 decreased vocalization 0.244223912190055 0.463568852783488 1.1171763538242 0.285714285714286 19.1 19 1 increased body weight 0.00205413911290647 0.016616816401154 1.1171763538242 0.285714285714286 19.1 19 1 obese 0.053785056189124 0.18607663957023 1.1171763538242 0.285714285714286 19.1 19 1 increased circulating aspartate transaminase level 0.075781421255145 0.237264047038607 1.1171763538242 0.285714285714286 19.1 19 1 increased circulating luteinizing hormone level 0.195362356598813 0.401591001274304 1.1171763538242 0.285714285714286 19.1 19 1 abnormal ovulation 0.195362356598813 0.401591001274304 1.1171763538242 0.285714285714286 19.1 19 1 abnormal suckling behavior 0.0445970926862559 0.159275331022343 1.11082876090475 0.284090909090909 19.1 19 1 increased circulating glucose level 0.0142847698898014 0.0710227553486775 1.10925311727226 0.283687943262411 19.1 19 1 abnormal femur morphology 0.0741018056292429 0.232151437660884 1.10883921685537 0.283582089552239 19.1 19 1 abnormal lymphocyte physiology 0.127239611474005 0.329889232420683 1.10503313258698 0.282608695652174 19.1 19 1 impaired macrophage chemotaxis 0.15422753170432 0.382840444075097 1.10285358005723 0.282051282051282 19.1 19 1 decreased B-1 B cell number 0.15422753170432 0.382840444075097 1.10285358005723 0.282051282051282 19.1 19 1 increased dopamine level 0.188756331481887 0.401591001274304 1.0997204732957 0.28125 19.1 19 1 abnormal lumbar vertebrae morphology 0.188756331481887 0.401591001274304 1.0997204732957 0.28125 19.1 19 1 abnormal response/metabolism to endogenous compounds 0.0595896145994846 0.195513566910096 1.09674020101035 0.280487804878049 19.1 19 1 abnormal digestive system physiology 0.123666879019059 0.324495107130706 1.09483282674772 0.28 19.1 19 1 abnormal keratinocyte physiology 0.234293626983778 0.445910785862393 1.09483282674772 0.28 19.1 19 1 abnormal feces composition 0.234293626983778 0.445910785862393 1.09483282674772 0.28 19.1 19 1 abnormal preimplantation embryo development 0.234293626983778 0.445910785862393 1.09483282674772 0.28 19.1 19 1 decreased susceptibility to injury 0.083966023653545 0.255962602742884 1.09253275778396 0.279411764705882 19.1 19 1 abnormal male reproductive system morphology 0.149472222126815 0.379787694116907 1.09119550838643 0.27906976744186 19.1 19 1 polyphagia 0.120081563466782 0.315253708837593 1.08614367732909 0.277777777777778 19.1 19 1 abnormal epidermis stratum granulosum morphology 0.182192635706971 0.401591001274304 1.08614367732909 0.277777777777778 19.1 19 1 abnormal trophoblast giant cell morphology 0.182192635706971 0.401591001274304 1.08614367732909 0.277777777777778 19.1 19 1 underdeveloped hair follicles 0.297503354373712 0.531255989953056 1.08614367732909 0.277777777777778 19.1 19 1 thick dermal layer 0.297503354373712 0.531255989953056 1.08614367732909 0.277777777777778 19.1 19 1 abnormal thymus cortex morphology 0.297503354373712 0.531255989953056 1.08614367732909 0.277777777777778 19.1 19 1 abnormal thymus medulla morphology 0.297503354373712 0.531255989953056 1.08614367732909 0.277777777777778 19.1 19 1 abnormal white adipose tissue morphology 0.297503354373712 0.531255989953056 1.08614367732909 0.277777777777778 19.1 19 1 acidosis 0.297503354373712 0.531255989953056 1.08614367732909 0.277777777777778 19.1 19 1 absent allantois 0.297503354373712 0.531255989953056 1.08614367732909 0.277777777777778 19.1 19 1 abnormal redox activity 0.297503354373712 0.531255989953056 1.08614367732909 0.277777777777778 19.1 19 1 abnormal neutrophil morphology 0.297503354373712 0.531255989953056 1.08614367732909 0.277777777777778 19.1 19 1 abnormal sperm axoneme morphology 0.297503354373712 0.531255989953056 1.08614367732909 0.277777777777778 19.1 19 1 atrioventricular block 0.297503354373712 0.531255989953056 1.08614367732909 0.277777777777778 19.1 19 1 primary atelectasis 0.297503354373712 0.531255989953056 1.08614367732909 0.277777777777778 19.1 19 1 increased effector memory CD4-positive, alpha-beta T cell number 0.297503354373712 0.531255989953056 1.08614367732909 0.277777777777778 19.1 19 1 increased sensitivity to induced morbidity/mortality 0.010186621319678 0.0564977046436993 1.08378249542185 0.277173913043478 19.1 19 1 decreased T cell proliferation 0.0197083509953373 0.0907861538905583 1.08320815387685 0.277027027027027 19.1 19 1 decreased monocyte cell number 0.0974095229661138 0.285618143663744 1.08280169678346 0.276923076923077 19.1 19 1 abnormal tibia morphology 0.144742914324062 0.368147238630986 1.08152178934045 0.276595744680851 19.1 19 1 abnormal T-helper 1 physiology 0.144742914324062 0.368147238630986 1.08152178934045 0.276595744680851 19.1 19 1 decreased granulocyte number 0.22472189912962 0.428185158241999 1.07865303127854 0.275862068965517 19.1 19 1 stomach inflammation 0.22472189912962 0.428185158241999 1.07865303127854 0.275862068965517 19.1 19 1 increased lung adenocarcinoma incidence 0.140083727815151 0.359606060825788 1.07336551641933 0.274509803921569 19.1 19 1 decreased sensitivity to induced morbidity/mortality 0.169509477770688 0.401591001274304 1.06639561046856 0.272727272727273 19.1 19 1 abnormal facial nerve morphology 0.282211684585921 0.506860336034281 1.06639561046856 0.272727272727273 19.1 19 1 increased myocardial infarction size 0.282211684585921 0.506860336034281 1.06639561046856 0.272727272727273 19.1 19 1 abnormal lysosome physiology 0.282211684585921 0.506860336034281 1.06639561046856 0.272727272727273 19.1 19 1 impaired humoral immune response 0.282211684585921 0.506860336034281 1.06639561046856 0.272727272727273 19.1 19 1 impaired fertilization 0.106165556792842 0.285618143663744 1.06131753613299 0.271428571428571 19.1 19 1 dehydration 0.106165556792842 0.285618143663744 1.06131753613299 0.271428571428571 19.1 19 1 abnormal kidney physiology 0.163462788210076 0.401591001274304 1.05899008539586 0.270833333333333 19.1 19 1 increased trabecular bone volume 0.206885368268491 0.407464254606391 1.05678844280668 0.27027027027027 19.1 19 1 abnormal respiratory electron transport chain 0.206885368268491 0.407464254606391 1.05678844280668 0.27027027027027 19.1 19 1 abnormal erythrocyte osmotic lysis 0.268297434937 0.488689807602989 1.05272387187281 0.269230769230769 19.1 19 1 scaly skin 0.198627294502027 0.401591001274304 1.04905584444468 0.268292682926829 19.1 19 1 epidermal hyperplasia 0.14662445701801 0.372742296200612 1.04269793023592 0.266666666666667 19.1 19 1 abnormal heart tube morphology 0.255543571997998 0.483579030311921 1.04269793023592 0.266666666666667 19.1 19 1 increased metastatic potential 0.255543571997998 0.483579030311921 1.04269793023592 0.266666666666667 19.1 19 1 arrested T cell differentiation 0.255543571997998 0.483579030311921 1.04269793023592 0.266666666666667 19.1 19 1 abnormal vision 0.24377982542272 0.46343317977762 1.03503103369007 0.264705882352941 19.1 19 1 decreased regulatory T cell number 0.24377982542272 0.46343317977762 1.03503103369007 0.264705882352941 19.1 19 1 abnormal long term depression 0.341734746044219 0.575252735448294 1.02897822062756 0.263157894736842 19.1 19 1 abnormal neurotransmitter level 0.341734746044219 0.575252735448294 1.02897822062756 0.263157894736842 19.1 19 1 abnormal cochlear inner hair cell morphology 0.341734746044219 0.575252735448294 1.02897822062756 0.263157894736842 19.1 19 1 absent amnion 0.341734746044219 0.575252735448294 1.02897822062756 0.263157894736842 19.1 19 1 decreased circulating magnesium level 0.341734746044219 0.575252735448294 1.02897822062756 0.263157894736842 19.1 19 1 absent vitelline blood vessels 0.16953868649213 0.401591001274304 1.02897822062756 0.263157894736842 19.1 19 1 increased T cell proliferation 0.0877163747356859 0.265760261192774 1.02320824929693 0.261682242990654 19.1 19 1 failure of embryo implantation 0.321362421957224 0.56855549403883 1.02003058392645 0.260869565217391 19.1 19 1 increased susceptibility to age related obesity 0.321362421957224 0.56855549403883 1.02003058392645 0.260869565217391 19.1 19 1 abnormal crista ampullaris morphology 0.321362421957224 0.56855549403883 1.02003058392645 0.260869565217391 19.1 19 1 abnormal B cell morphology 0.321362421957224 0.56855549403883 1.02003058392645 0.260869565217391 19.1 19 1 abnormal ulna morphology 0.321362421957224 0.56855549403883 1.02003058392645 0.260869565217391 19.1 19 1 decreased effector memory CD8-positive, alpha-beta T cell number 0.321362421957224 0.56855549403883 1.02003058392645 0.260869565217391 19.1 19 1 abnormal epidermal layer morphology 0.151220354587666 0.382840444075097 1.02003058392645 0.260869565217391 19.1 19 1 increased body length 0.204308459082694 0.402707838326625 1.01663048198003 0.26 19.1 19 1 wrinkled skin 0.303501778537115 0.541384492012244 1.01373409884048 0.259259259259259 19.1 19 1 abnormal palate morphology 0.303501778537115 0.541384492012244 1.01373409884048 0.259259259259259 19.1 19 1 abnormal CD8-positive, alpha beta T cell morphology 0.287560374346091 0.516280354518875 1.00906251313154 0.258064516129032 19.1 19 1 abnormal lens fiber morphology 0.259990816966881 0.488689807602989 1.00259416368839 0.256410256410256 19.1 19 1 increased autoantibody level 0.259990816966881 0.488689807602989 1.00259416368839 0.256410256410256 19.1 19 1 abnormal homeostasis 0.247889481980407 0.470167812753536 1.00026254935423 0.255813953488372 19.1 19 1 impaired macrophage phagocytosis 0.247889481980407 0.470167812753536 1.00026254935423 0.255813953488372 19.1 19 1 increased cellular sensitivity to gamma-irradiation 0.236692046937733 0.450303225053622 0.998327805545034 0.25531914893617 19.1 19 1 abnormal leukocyte migration 0.249162795769737 0.47240278542471 0.977529309596179 0.25 19.1 19 1 increased liver weight 0.170634166165258 0.401591001274304 0.977529309596179 0.25 19.1 19 1 abnormal lymph node morphology 0.261101799846952 0.488689807602989 0.977529309596179 0.25 19.1 19 1 abnormal myelopoiesis 0.274016150050314 0.492852619848268 0.977529309596179 0.25 19.1 19 1 abnormal gametogenesis 0.274016150050314 0.492852619848268 0.977529309596179 0.25 19.1 19 1 abnormal female reproductive system morphology 0.288067429195453 0.516817692119502 0.977529309596179 0.25 19.1 19 1 abnormal pancreatic beta cell morphology 0.288067429195453 0.516817692119502 0.977529309596179 0.25 19.1 19 1 abnormal diaphragm morphology 0.320495055300826 0.568435971522856 0.977529309596179 0.25 19.1 19 1 abnormal spongiotrophoblast layer morphology 0.320495055300826 0.568435971522856 0.977529309596179 0.25 19.1 19 1 abnormal circulating cholesterol level 0.33954825251655 0.575252735448294 0.977529309596179 0.25 19.1 19 1 abnormal spleen germinal center morphology 0.33954825251655 0.575252735448294 0.977529309596179 0.25 19.1 19 1 hypoxia 0.33954825251655 0.575252735448294 0.977529309596179 0.25 19.1 19 1 abnormal cellular extravasation 0.361201966142515 0.575252735448294 0.977529309596179 0.25 19.1 19 1 abnormal inner cell mass apoptosis 0.361201966142515 0.575252735448294 0.977529309596179 0.25 19.1 19 1 decreased paired-pulse facilitation 0.386352637846632 0.605196591085325 0.977529309596179 0.25 19.1 19 1 abnormal male reproductive system physiology 0.386352637846632 0.605196591085325 0.977529309596179 0.25 19.1 19 1 abnormal physiological neovascularization 0.386352637846632 0.605196591085325 0.977529309596179 0.25 19.1 19 1 abnormal thymocyte activation 0.386352637846632 0.605196591085325 0.977529309596179 0.25 19.1 19 1 increased urine calcium level 0.386352637846632 0.605196591085325 0.977529309596179 0.25 19.1 19 1 altered response to myocardial infarction 0.300943184346043 0.53720572017279 0.955806436049597 0.244444444444444 19.1 19 1 arrested B cell differentiation 0.316919085548171 0.562494630967588 0.953687131313345 0.24390243902439 19.1 19 1 increased cardiomyocyte apoptosis 0.354067673212753 0.575252735448294 0.947907209305386 0.242424242424242 19.1 19 1 increased inflammatory response 0.208047926042301 0.40784904770767 0.946659962977352 0.242105263157895 19.1 19 1 abnormal immune system physiology 0.170729667481081 0.401591001274304 0.945996106060818 0.241935483870968 19.1 19 1 increased eosinophil cell number 0.27056104138712 0.488689807602989 0.945996106060818 0.241935483870968 19.1 19 1 abnormal microglial cell morphology 0.376083910412391 0.590404735924794 0.943821402368724 0.241379310344828 19.1 19 1 abnormal circulating glucose level 0.376083910412391 0.590404735924794 0.943821402368724 0.241379310344828 19.1 19 1 focal hair loss 0.376083910412391 0.590404735924794 0.943821402368724 0.241379310344828 19.1 19 1 aphagia 0.376083910412391 0.590404735924794 0.943821402368724 0.241379310344828 19.1 19 1 increased double-positive T cell number 0.376083910412391 0.590404735924794 0.943821402368724 0.241379310344828 19.1 19 1 increased pre-B cell number 0.401278283771589 0.623083477454325 0.938428137212332 0.24 19.1 19 1 abnormal energy expenditure 0.401278283771589 0.623083477454325 0.938428137212332 0.24 19.1 19 1 decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 0.401278283771589 0.623083477454325 0.938428137212332 0.24 19.1 19 1 increased liver glycogen level 0.401278283771589 0.623083477454325 0.938428137212332 0.24 19.1 19 1 abnormal urine homeostasis 0.22383402224612 0.42682033755249 0.936798921696338 0.239583333333333 19.1 19 1 abnormal CD4-positive, alpha-beta T cell physiology 0.26760616081355 0.488689807602989 0.936225254261129 0.23943661971831 19.1 19 1 delayed wound healing 0.328514688020877 0.575252735448294 0.93502803526591 0.239130434782609 19.1 19 1 abnormal eye pigmentation 0.430767864614313 0.660304699825475 0.930980294853504 0.238095238095238 19.1 19 1 trunk curl 0.430767864614313 0.660304699825475 0.930980294853504 0.238095238095238 19.1 19 1 abnormal hematopoietic system physiology 0.430767864614313 0.660304699825475 0.930980294853504 0.238095238095238 19.1 19 1 increased incidence of induced tumors 0.430767864614313 0.660304699825475 0.930980294853504 0.238095238095238 19.1 19 1 abnormal associative learning 0.430767864614313 0.660304699825475 0.930980294853504 0.238095238095238 19.1 19 1 increased vasoconstriction 0.430767864614313 0.660304699825475 0.930980294853504 0.238095238095238 19.1 19 1 embryonic lethality at implantation, complete penetrance 0.430767864614313 0.660304699825475 0.930980294853504 0.238095238095238 19.1 19 1 abnormal hair cycle 0.412770100364598 0.640128194923277 0.912360688956434 0.233333333333333 19.1 19 1 salivary gland inflammation 0.412770100364598 0.640128194923277 0.912360688956434 0.233333333333333 19.1 19 1 abnormal pain threshold 0.412770100364598 0.640128194923277 0.912360688956434 0.233333333333333 19.1 19 1 abnormal intestinal mucosa morphology 0.376197590528964 0.590404735924794 0.909329590322027 0.232558139534884 19.1 19 1 increased lymphocyte cell number 0.323952303698994 0.572933775649661 0.906693852379064 0.231884057971014 19.1 19 1 decreased body temperature 0.365513305317075 0.575252735448294 0.90233474731955 0.230769230769231 19.1 19 1 acanthosis 0.397871397454585 0.618565688230175 0.90233474731955 0.230769230769231 19.1 19 1 decreased bone resorption 0.441172538421967 0.672024916916499 0.90233474731955 0.230769230769231 19.1 19 1 abnormal T cell activation 0.331342949858031 0.575252735448294 0.898270176385678 0.22972972972973 19.1 19 1 abnormal hair shaft morphology 0.384954521510949 0.603957346110681 0.896068533796497 0.229166666666667 19.1 19 1 increased red blood cell distribution width 0.422033393035134 0.652257263233859 0.893741083059364 0.228571428571429 19.1 19 1 increased body size 0.47446085874031 0.709498153528236 0.888663008723799 0.227272727272727 19.1 19 1 decreased susceptibility to viral infection induced morbidity/mortality 0.47446085874031 0.709498153528236 0.888663008723799 0.227272727272727 19.1 19 1 increased circulating creatine kinase level 0.47446085874031 0.709498153528236 0.888663008723799 0.227272727272727 19.1 19 1 decreased inflammatory response 0.344466870722076 0.575252735448294 0.884431280110828 0.226190476190476 19.1 19 1 absent mature ovarian follicles 0.449289603786662 0.683761327267863 0.882929698990097 0.225806451612903 19.1 19 1 autoimmune response 0.449289603786662 0.683761327267863 0.882929698990097 0.225806451612903 19.1 19 1 decreased IgG level 0.320851503769436 0.56855549403883 0.880657035672233 0.225225225225225 19.1 19 1 increased fluid intake 0.413506241076084 0.641069974868657 0.877781420861875 0.224489795918367 19.1 19 1 head tilt 0.455909745189152 0.690877545633881 0.86891494186327 0.222222222222222 19.1 19 1 skin lesions 0.405576232247492 0.629560610118961 0.86891494186327 0.222222222222222 19.1 19 1 abnormal cytokine secretion 0.328431086957105 0.575252735448294 0.863272637045976 0.220779220779221 19.1 19 1 increased tumor growth/size 0.461483654823041 0.699111200592153 0.858318418182011 0.219512195121951 19.1 19 1 abnormal serotonin level 0.485352077362696 0.709498153528236 0.855338145896656 0.21875 19.1 19 1 abnormal T-helper 2 physiology 0.447143557701931 0.680911906815765 0.853116488374847 0.218181818181818 19.1 19 1 abnormal retinal cone cell morphology 0.516988202291167 0.728410168903584 0.850025486605373 0.217391304347826 19.1 19 1 pancreas inflammation 0.516988202291167 0.728410168903584 0.850025486605373 0.217391304347826 19.1 19 1 increased susceptibility to fungal infection 0.516988202291167 0.728410168903584 0.850025486605373 0.217391304347826 19.1 19 1 impaired hematopoiesis 0.470512134243167 0.709498153528236 0.843358620043762 0.215686274509804 19.1 19 1 abnormal cytotoxic T cell physiology 0.492881425542688 0.709498153528236 0.837882265368153 0.214285714285714 19.1 19 1 reddish skin 0.51895034726339 0.730760820162855 0.837882265368153 0.214285714285714 19.1 19 1 straub tail 0.51895034726339 0.730760820162855 0.837882265368153 0.214285714285714 19.1 19 1 abnormal T cell subpopulation ratio 0.520697878479988 0.732806773815543 0.829418808142212 0.212121212121212 19.1 19 1 decreased sensitivity to xenobiotic induced morbidity/mortality 0.520697878479988 0.732806773815543 0.829418808142212 0.212121212121212 19.1 19 1 hypopigmentation 0.557984580225023 0.784394825266881 0.814607757996816 0.208333333333333 19.1 19 1 increased susceptibility to weight gain 0.555100411075993 0.780560922866892 0.8050241373145 0.205882352941176 19.1 19 1 hypertension 0.55398707473307 0.779436000225402 0.799796707851419 0.204545454545455 19.1 19 1 abnormal response to infection 0.554684941013822 0.780197224072311 0.791922478660196 0.20253164556962 19.1 19 1 abnormal inflammatory response 0.623440382597612 0.836015068308118 0.760300574130361 0.194444444444444 19.1 19 1 abnormal body temperature homeostasis 0.626352535397921 0.839241546890563 0.756796884848655 0.193548387096774 19.1 19 1 abnormal T cell proliferation 0.626352535397921 0.839241546890563 0.756796884848655 0.193548387096774 19.1 19 1 abnormal mitochondrial ATP synthesis coupled electron transport 0.626352535397921 0.839241546890563 0.756796884848655 0.193548387096774 19.1 19 1 decreased IgA level 0.635048691052172 0.846284935482185 0.751945622766292 0.192307692307692 19.1 19 1 increased systemic arterial blood pressure 0.639344918662759 0.851604008125093 0.748745854158775 0.191489361702128 19.1 19 1 increased insulin secretion 0.650892385977844 0.866753110342552 0.739751909964676 0.189189189189189 19.1 19 1 thick epidermis 0.691303380398177 0.901030735520286 0.726164629985733 0.185714285714286 19.1 19 1 failure of blastocyst to hatch from the zona pellucida 0.701929366741756 0.914640806584662 0.698235221140128 0.178571428571429 19.1 19 1 abnormal skin physiology 0.718422200204078 0.934418417258899 0.690020689126715 0.176470588235294 19.1 19 1 decreased susceptibility to parasitic infection 0.809645729684693 1 0.610955818497612 0.15625 19.1 19 1 abnormal leukocyte adhesion 0.83424456502405 1 0.601556498213033 0.153846153846154 19.1 19 1 increased susceptibility to bacterial infection induced morbidity/mortality 0.89206192679269 1 0.597379022530998 0.152777777777778 19.1 19 1 abnormal NK cell physiology 0.898141472685417 1 0.576902543368237 0.147540983606557 19.1 19 1 decreased susceptibility to induced arthritis 0.91732186757706 1 0.548788384334697 0.140350877192982 19.1 19 1 increased susceptibility to parasitic infection 0.968680461247297 1 0.521348965117962 0.133333333333333 19.1 19 1 abnormal thrombosis 0.986363108035318 1 0.383344827292619 0.0980392156862745 19.1 19 1 impaired natural killer cell mediated cytotoxicity 0.994729536949275 1 0.342992740209186 0.087719298245614 19.1 19 1 abnormal telomere morphology 3.56716148708889e-05 0.000558070075417208 2.11944827586207 1 19.3 19 3 accumulation of giant lysosomes in kidney/renal tubule cells 0.000111331415290427 0.00141364362632942 2.11944827586207 1 19.3 19 3 absent ectoplacental cone 0.00108424188106513 0.00982437081774272 2.11944827586207 1 19.3 19 3 abnormal hippocampal fimbria morphology 0.00108424188106513 0.00982437081774272 2.11944827586207 1 19.3 19 3 decreased sensitivity to skin irradiation 0.00338329350173395 0.0234427370071398 2.11944827586207 1 19.3 19 3 skin hyperplasia 0.00338329350173395 0.0234427370071398 2.11944827586207 1 19.3 19 3 decreased lysosomal enzyme secretion 0.00338329350173395 0.0234427370071398 2.11944827586207 1 19.3 19 3 ectopic cartilage 0.00338329350173395 0.0234427370071398 2.11944827586207 1 19.3 19 3 scapular bone foramen 0.00338329350173395 0.0234427370071398 2.11944827586207 1 19.3 19 3 enlarged aortic valve 0.00338329350173395 0.0234427370071398 2.11944827586207 1 19.3 19 3 pale lung 0.00338329350173395 0.0234427370071398 2.11944827586207 1 19.3 19 3 abnormal mitophagy 0.00338329350173395 0.0234427370071398 2.11944827586207 1 19.3 19 3 decreased small intestinal villus height 0.00338329350173395 0.0234427370071398 2.11944827586207 1 19.3 19 3 decreased neuronal precursor proliferation 0.00338329350173395 0.0234427370071398 2.11944827586207 1 19.3 19 3 abnormal eye distance/ position 8.9102451895962e-05 0.00119240437459677 1.92677115987461 0.909090909090909 19.3 19 3 abnormal radial glial cell morphology 8.9102451895962e-05 0.00119240437459677 1.92677115987461 0.909090909090909 19.3 19 3 abnormal coronal suture morphology 8.9102451895962e-05 0.00119240437459677 1.92677115987461 0.909090909090909 19.3 19 3 reduced sympathetic cervical ganglion size 8.9102451895962e-05 0.00119240437459677 1.92677115987461 0.909090909090909 19.3 19 3 abnormal respiratory conducting tube morphology 0.000253856944678703 0.00283806359500348 1.90750344827586 0.9 19.3 19 3 increased circulating fructosamine level 0.000253856944678703 0.00283806359500348 1.90750344827586 0.9 19.3 19 3 decreased circulating lactate level 0.000253856944678703 0.00283806359500348 1.90750344827586 0.9 19.3 19 3 increased neuronal precursor cell number 0.000716609818646729 0.00686923670090073 1.88395402298851 0.888888888888889 19.3 19 3 increased cardiac muscle glycogen level 0.000716609818646729 0.00686923670090073 1.88395402298851 0.888888888888889 19.3 19 3 increased cochlear outer hair cell number 7.10368974790256e-06 0.000136451183381526 1.85451724137931 0.875 19.3 19 3 absent eyelids 0.00200023667184475 0.0159218839078842 1.85451724137931 0.875 19.3 19 3 increased cardiac output 0.00200023667184475 0.0159218839078842 1.85451724137931 0.875 19.3 19 3 elevated level of mitotic sister chromatid exchange 0.00200023667184475 0.0159218839078842 1.85451724137931 0.875 19.3 19 3 tau protein deposits 0.00200023667184475 0.0159218839078842 1.85451724137931 0.875 19.3 19 3 abnormal somite size 0.00200023667184475 0.0159218839078842 1.85451724137931 0.875 19.3 19 3 abnormal vertebral body development 0.00200023667184475 0.0159218839078842 1.85451724137931 0.875 19.3 19 3 craniofacial phenotype 0.00200023667184475 0.0159218839078842 1.85451724137931 0.875 19.3 19 3 abnormal cerebellum deep nucleus morphology 0.00200023667184475 0.0159218839078842 1.85451724137931 0.875 19.3 19 3 lung situs inversus 0.00200023667184475 0.0159218839078842 1.85451724137931 0.875 19.3 19 3 decreased alveolar lamellar body number 0.00200023667184475 0.0159218839078842 1.85451724137931 0.875 19.3 19 3 abnormal foramen magnum morphology 0.00200023667184475 0.0159218839078842 1.85451724137931 0.875 19.3 19 3 impaired neuron differentiation 0.00200023667184475 0.0159218839078842 1.85451724137931 0.875 19.3 19 3 ocular hypertelorism 2.81982692399961e-08 9.74211037979032e-07 1.85451724137931 0.875 19.3 19 3 abnormal placenta size 1.94909982232904e-05 0.000330947836726519 1.83685517241379 0.866666666666667 19.3 19 3 abnormal sagittal suture morphology 5.30025276362524e-05 0.000766533648227778 1.81666995073892 0.857142857142857 19.3 19 3 abnormal renal tubule epithelial cell primary cilium morphology 5.30025276362524e-05 0.000766533648227778 1.81666995073892 0.857142857142857 19.3 19 3 polyphalangy 0.00550502573329759 0.0354760401854346 1.81666995073892 0.857142857142857 19.3 19 3 abnormal tumor incidence 0.00550502573329759 0.0354760401854346 1.81666995073892 0.857142857142857 19.3 19 3 decreased mortality induced by ionizing radiation 0.00550502573329759 0.0354760401854346 1.81666995073892 0.857142857142857 19.3 19 3 abnormal superior semicircular canal morphology 0.00550502573329759 0.0354760401854346 1.81666995073892 0.857142857142857 19.3 19 3 aorta coarctation 0.00550502573329759 0.0354760401854346 1.81666995073892 0.857142857142857 19.3 19 3 abnormal Purkinje cell innervation 0.00550502573329759 0.0354760401854346 1.81666995073892 0.857142857142857 19.3 19 3 enhanced behavioral response to alcohol 0.00550502573329759 0.0354760401854346 1.81666995073892 0.857142857142857 19.3 19 3 thick pulmonary valve 0.00550502573329759 0.0354760401854346 1.81666995073892 0.857142857142857 19.3 19 3 embryonic lethality at implantation, incomplete penetrance 0.00550502573329759 0.0354760401854346 1.81666995073892 0.857142857142857 19.3 19 3 abnormal scapula morphology 5.70176829911387e-07 1.43264127717634e-05 1.81666995073892 0.857142857142857 19.3 19 3 increased foot pad pigmentation 0.0001426597937624 0.00178773922913838 1.79337931034483 0.846153846153846 19.3 19 3 abnormal thymus involution 0.00037944016168793 0.004059601729887 1.76620689655172 0.833333333333333 19.3 19 3 decreased synaptic depression 0.00037944016168793 0.004059601729887 1.76620689655172 0.833333333333333 19.3 19 3 abnormal pulmonary valve cusp morphology 0.00037944016168793 0.004059601729887 1.76620689655172 0.833333333333333 19.3 19 3 prenatal growth retardation 0.00037944016168793 0.004059601729887 1.76620689655172 0.833333333333333 19.3 19 3 abnormal urethra morphology 0.0148785516050781 0.075918763318219 1.76620689655172 0.833333333333333 19.3 19 3 delayed brain development 0.0148785516050781 0.075918763318219 1.76620689655172 0.833333333333333 19.3 19 3 abnormal cervical lymph node morphology 0.0148785516050781 0.075918763318219 1.76620689655172 0.833333333333333 19.3 19 3 increased post-tetanic potentiation 0.0148785516050781 0.075918763318219 1.76620689655172 0.833333333333333 19.3 19 3 decreased liver function 0.0148785516050781 0.075918763318219 1.76620689655172 0.833333333333333 19.3 19 3 enlarged pancreas 0.0148785516050781 0.075918763318219 1.76620689655172 0.833333333333333 19.3 19 3 abnormal milk ejection 0.0148785516050781 0.075918763318219 1.76620689655172 0.833333333333333 19.3 19 3 abnormal lambdoidal suture morphology 0.0148785516050781 0.075918763318219 1.76620689655172 0.833333333333333 19.3 19 3 abnormal eyelid development 0.0148785516050781 0.075918763318219 1.76620689655172 0.833333333333333 19.3 19 3 abnormal neural crest cell morphology 0.0148785516050781 0.075918763318219 1.76620689655172 0.833333333333333 19.3 19 3 abnormal olfactory bulb layer morphology 0.0148785516050781 0.075918763318219 1.76620689655172 0.833333333333333 19.3 19 3 ectopic hippocampus pyramidal cells 0.0148785516050781 0.075918763318219 1.76620689655172 0.833333333333333 19.3 19 3 enlarged lymphatic vessel 0.0148785516050781 0.075918763318219 1.76620689655172 0.833333333333333 19.3 19 3 common truncal valve 0.0148785516050781 0.075918763318219 1.76620689655172 0.833333333333333 19.3 19 3 abnormal mandibular prominence morphology 0.0148785516050781 0.075918763318219 1.76620689655172 0.833333333333333 19.3 19 3 increased total retina thickness 0.0148785516050781 0.075918763318219 1.76620689655172 0.833333333333333 19.3 19 3 abnormal vertebral artery origin 0.0148785516050781 0.075918763318219 1.76620689655172 0.833333333333333 19.3 19 3 additional anastomosis between intracranial vertebral arteries 0.0148785516050781 0.075918763318219 1.76620689655172 0.833333333333333 19.3 19 3 abnormal Wolffian duct connection 0.0148785516050781 0.075918763318219 1.76620689655172 0.833333333333333 19.3 19 3 increased body fat mass 0.0148785516050781 0.075918763318219 1.76620689655172 0.833333333333333 19.3 19 3 abnormal bone marrow cavity morphology 2.82669856717221e-05 0.000450731582425698 1.74542799188641 0.823529411764706 19.3 19 3 increased adenoma incidence 2.18816580370988e-06 4.75376632028674e-05 1.73409404388715 0.818181818181818 19.3 19 3 premature suture closure 0.000995252162201043 0.00915227265610017 1.73409404388715 0.818181818181818 19.3 19 3 abnormal proximal-distal axis patterning 0.000995252162201043 0.00915227265610017 1.73409404388715 0.818181818181818 19.3 19 3 abnormal dorsal-ventral polarity of the somites 0.000995252162201043 0.00915227265610017 1.73409404388715 0.818181818181818 19.3 19 3 scoliosis 1.39328069621798e-08 5.2117078674319e-07 1.72205172413793 0.8125 19.3 19 3 intraventricular hemorrhage 7.31693349499717e-05 0.00101397615982203 1.72205172413793 0.8125 19.3 19 3 malocclusion 1.13208026746745e-09 5.16706360610141e-08 1.7184715750233 0.810810810810811 19.3 19 3 left pulmonary isomerism 5.62218274063992e-06 0.000110993488629697 1.71574384236453 0.80952380952381 19.3 19 3 abnormal embryonic/fetal subventricular zone morphology 5.62218274063992e-06 0.000110993488629697 1.71574384236453 0.80952380952381 19.3 19 3 increased muscle cell glucose uptake 5.62218274063992e-06 0.000110993488629697 1.71574384236453 0.80952380952381 19.3 19 3 abnormal lysosome morphology 2.87888306560999e-09 1.20356665978233e-07 1.70733333333333 0.805555555555556 19.3 19 3 anencephaly 1.43013959261764e-05 0.000249647174500799 1.69555862068966 0.8 19.3 19 3 increased skin tumor incidence 1.43013959261764e-05 0.000249647174500799 1.69555862068966 0.8 19.3 19 3 absent ductus venosus valve 1.43013959261764e-05 0.000249647174500799 1.69555862068966 0.8 19.3 19 3 delayed intramembranous bone ossification 0.0001870486452881 0.0022423301453212 1.69555862068966 0.8 19.3 19 3 abnormal olfactory nerve morphology 0.0001870486452881 0.0022423301453212 1.69555862068966 0.8 19.3 19 3 abnormal secondary palate development 0.0001870486452881 0.0022423301453212 1.69555862068966 0.8 19.3 19 3 absent palatine bone horizontal plate 0.00256762131451883 0.0192959456793522 1.69555862068966 0.8 19.3 19 3 ketoaciduria 0.00256762131451883 0.0192959456793522 1.69555862068966 0.8 19.3 19 3 osteosclerosis 0.00256762131451883 0.0192959456793522 1.69555862068966 0.8 19.3 19 3 increased platelet aggregation 0.00256762131451883 0.0192959456793522 1.69555862068966 0.8 19.3 19 3 abnormal hippocampus neuron morphology 0.00256762131451883 0.0192959456793522 1.69555862068966 0.8 19.3 19 3 abnormal inferior vena cava valve morphology 0.00256762131451883 0.0192959456793522 1.69555862068966 0.8 19.3 19 3 abnormal adaptive thermogenesis 0.00256762131451883 0.0192959456793522 1.69555862068966 0.8 19.3 19 3 kyphoscoliosis 3.59780105738691e-05 0.000561099067727269 1.67324863883848 0.789473684210526 19.3 19 3 increased lactate dehydrogenase level 0.000471403102891605 0.00481566824822533 1.66528078817734 0.785714285714286 19.3 19 3 increased hemangioma incidence 0.000471403102891605 0.00481566824822533 1.66528078817734 0.785714285714286 19.3 19 3 amyloid beta deposits 0.000471403102891605 0.00481566824822533 1.66528078817734 0.785714285714286 19.3 19 3 absent olfactory bulb 0.000471403102891605 0.00481566824822533 1.66528078817734 0.785714285714286 19.3 19 3 vascular smooth muscle hypoplasia 0.000471403102891605 0.00481566824822533 1.66528078817734 0.785714285714286 19.3 19 3 multiple persisting craniopharyngeal ducts 0.000471403102891605 0.00481566824822533 1.66528078817734 0.785714285714286 19.3 19 3 abnormal vitelline vein topology 0.000471403102891605 0.00481566824822533 1.66528078817734 0.785714285714286 19.3 19 3 abnormal cell differentiation 1.86953520776462e-09 8.08777187706869e-08 1.65420353238015 0.780487804878049 19.3 19 3 abnormal mitral valve morphology 8.94003681858484e-05 0.00119240437459677 1.64845977011494 0.777777777777778 19.3 19 3 abnormal phrenic nerve morphology 8.94003681858484e-05 0.00119240437459677 1.64845977011494 0.777777777777778 19.3 19 3 abnormal aerobic respiration 8.94003681858484e-05 0.00119240437459677 1.64845977011494 0.777777777777778 19.3 19 3 abnormal hypoglossal nerve topology 8.94003681858484e-05 0.00119240437459677 1.64845977011494 0.777777777777778 19.3 19 3 heart hyperplasia 0.00649293065803782 0.0399287144916417 1.64845977011494 0.777777777777778 19.3 19 3 decreased level of surface class I molecules 0.00649293065803782 0.0399287144916417 1.64845977011494 0.777777777777778 19.3 19 3 abnormal posterior semicircular canal morphology 0.00649293065803782 0.0399287144916417 1.64845977011494 0.777777777777778 19.3 19 3 pancreas cysts 0.00649293065803782 0.0399287144916417 1.64845977011494 0.777777777777778 19.3 19 3 abnormal inguinal fat pad morphology 0.00649293065803782 0.0399287144916417 1.64845977011494 0.777777777777778 19.3 19 3 abnormal lung lobe morphology 0.00649293065803782 0.0399287144916417 1.64845977011494 0.777777777777778 19.3 19 3 abnormal infrahyoid muscle connection 0.00649293065803782 0.0399287144916417 1.64845977011494 0.777777777777778 19.3 19 3 symmetric azygos veins 0.00649293065803782 0.0399287144916417 1.64845977011494 0.777777777777778 19.3 19 3 cerebellum atrophy 0.00649293065803782 0.0399287144916417 1.64845977011494 0.777777777777778 19.3 19 3 abnormal occipital bone morphology 1.7297840326202e-05 0.000296747433182259 1.63775548589342 0.772727272727273 19.3 19 3 short premaxilla 0.00116870805477303 0.0103827188794568 1.63034482758621 0.769230769230769 19.3 19 3 axonal dystrophy 0.00116870805477303 0.0103827188794568 1.63034482758621 0.769230769230769 19.3 19 3 increased cochlear inner hair cell number 0.00116870805477303 0.0103827188794568 1.63034482758621 0.769230769230769 19.3 19 3 abnormal exocrine pancreas morphology 0.00116870805477303 0.0103827188794568 1.63034482758621 0.769230769230769 19.3 19 3 absent hypoglossal nerve 0.00116870805477303 0.0103827188794568 1.63034482758621 0.769230769230769 19.3 19 3 abnormal interatrial septum morphology 0.000219101970104282 0.00253482313704786 1.62075456389452 0.764705882352941 19.3 19 3 increased brain size 0.000219101970104282 0.00253482313704786 1.62075456389452 0.764705882352941 19.3 19 3 increased trabecular bone mass 0.000219101970104282 0.00253482313704786 1.62075456389452 0.764705882352941 19.3 19 3 increased cellular sensitivity to ionizing radiation 8.20879356212564e-06 0.000156470298741667 1.61078068965517 0.76 19.3 19 3 abnormal nervous system morphology 1.39871473964063e-15 1.88070427830058e-13 1.60970755128765 0.759493670886076 19.3 19 3 increased mortality induced by gamma-irradiation 1.61956441986329e-06 3.66242408582722e-05 1.60785731272295 0.758620689655172 19.3 19 3 pancreatic islet hyperplasia 7.67276706659983e-07 1.8711772625654e-05 1.58958620689655 0.75 19.3 19 3 rib bifurcation 3.86433956521316e-06 7.99543571172124e-05 1.58958620689655 0.75 19.3 19 3 vasculature congestion 0.000528686576302487 0.00530285426835659 1.58958620689655 0.75 19.3 19 3 loose skin 0.000528686576302487 0.00530285426835659 1.58958620689655 0.75 19.3 19 3 abnormal ear pigmentation 0.0160193929176561 0.0779808999660853 1.58958620689655 0.75 19.3 19 3 abnormal exoccipital bone morphology 0.0160193929176561 0.0779808999660853 1.58958620689655 0.75 19.3 19 3 failure of vascular branching 0.0160193929176561 0.0779808999660853 1.58958620689655 0.75 19.3 19 3 pointed snout 0.0160193929176561 0.0779808999660853 1.58958620689655 0.75 19.3 19 3 dermal cysts 0.0160193929176561 0.0779808999660853 1.58958620689655 0.75 19.3 19 3 hypospadia 0.0160193929176561 0.0779808999660853 1.58958620689655 0.75 19.3 19 3 absent tympanic ring 0.0160193929176561 0.0779808999660853 1.58958620689655 0.75 19.3 19 3 early eyelid opening 0.0160193929176561 0.0779808999660853 1.58958620689655 0.75 19.3 19 3 decreased susceptibility to age related obesity 0.0160193929176561 0.0779808999660853 1.58958620689655 0.75 19.3 19 3 colon polyps 0.0160193929176561 0.0779808999660853 1.58958620689655 0.75 19.3 19 3 abnormal ovary development 0.0160193929176561 0.0779808999660853 1.58958620689655 0.75 19.3 19 3 abnormal eyelid aperture 0.0160193929176561 0.0779808999660853 1.58958620689655 0.75 19.3 19 3 bowed fibula 0.0160193929176561 0.0779808999660853 1.58958620689655 0.75 19.3 19 3 abnormal choroid pigmentation 0.0160193929176561 0.0779808999660853 1.58958620689655 0.75 19.3 19 3 stomach epithelial hyperplasia 0.0160193929176561 0.0779808999660853 1.58958620689655 0.75 19.3 19 3 decreased hippocampus pyramidal cell number 0.0160193929176561 0.0779808999660853 1.58958620689655 0.75 19.3 19 3 increased caudal vertebrae number 0.0160193929176561 0.0779808999660853 1.58958620689655 0.75 19.3 19 3 abnormal hepatic vein morphology 0.0160193929176561 0.0779808999660853 1.58958620689655 0.75 19.3 19 3 pulmonary artery hypoplasia 0.0160193929176561 0.0779808999660853 1.58958620689655 0.75 19.3 19 3 delayed suture closure 0.0160193929176561 0.0779808999660853 1.58958620689655 0.75 19.3 19 3 abnormal stomach position or orientation 0.0160193929176561 0.0779808999660853 1.58958620689655 0.75 19.3 19 3 abnormal anterior commissure pars posterior morphology 0.0160193929176561 0.0779808999660853 1.58958620689655 0.75 19.3 19 3 decreased cranium length 0.0160193929176561 0.0779808999660853 1.58958620689655 0.75 19.3 19 3 increased cardiac stroke volume 0.0160193929176561 0.0779808999660853 1.58958620689655 0.75 19.3 19 3 absent hypoglossal canal 0.0160193929176561 0.0779808999660853 1.58958620689655 0.75 19.3 19 3 embryo cyst 0.0160193929176561 0.0779808999660853 1.58958620689655 0.75 19.3 19 3 abnormal superior cervical ganglion morphology 0.00284268816374038 0.0204729782865393 1.58958620689655 0.75 19.3 19 3 interstitial pneumonia 0.00284268816374038 0.0204729782865393 1.58958620689655 0.75 19.3 19 3 abnormal alisphenoid bone morphology 0.00284268816374038 0.0204729782865393 1.58958620689655 0.75 19.3 19 3 dilated bile duct 0.00284268816374038 0.0204729782865393 1.58958620689655 0.75 19.3 19 3 abnormal rostral-caudal body axis extension 0.00284268816374038 0.0204729782865393 1.58958620689655 0.75 19.3 19 3 decreased cochlear nerve compound action potential 0.00284268816374038 0.0204729782865393 1.58958620689655 0.75 19.3 19 3 abnormal thymus corticomedullary boundary morphology 0.00284268816374038 0.0204729782865393 1.58958620689655 0.75 19.3 19 3 decreased red blood cell distribution width 0.00284268816374038 0.0204729782865393 1.58958620689655 0.75 19.3 19 3 abnormal vitelline vein connection 0.00284268816374038 0.0204729782865393 1.58958620689655 0.75 19.3 19 3 preaxial polydactyly 1.80979997510893e-06 4.01953342686023e-05 1.57249388209121 0.741935483870968 19.3 19 3 abnormal apoptosis 2.87228996649123e-10 1.57029039376856e-08 1.56996168582375 0.740740740740741 19.3 19 3 abnormal eye muscle morphology 9.12151816909019e-06 0.000171243595815938 1.56996168582375 0.740740740740741 19.3 19 3 abnormal sacral vertebrae morphology 4.63973269584421e-05 0.000695261149452559 1.56654872563718 0.739130434782609 19.3 19 3 abnormal neurotransmitter level 0.00023898296949939 0.0027082921942129 1.56169872958258 0.736842105263158 19.3 19 3 abnormal optic vesicle formation 0.00023898296949939 0.0027082921942129 1.56169872958258 0.736842105263158 19.3 19 3 abnormal embryo size 1.99589009780079e-19 4.13731384856622e-17 1.55676289288984 0.734513274336283 19.3 19 3 abnormal pericyte morphology 0.00125337786130124 0.0109013196852687 1.55426206896552 0.733333333333333 19.3 19 3 abnormal branching involved in lung morphogenesis 0.00125337786130124 0.0109013196852687 1.55426206896552 0.733333333333333 19.3 19 3 heterochrony 0.00125337786130124 0.0109013196852687 1.55426206896552 0.733333333333333 19.3 19 3 abnormal Mullerian duct morphology 2.12808690749295e-05 0.000355683873820379 1.5488275862069 0.730769230769231 19.3 19 3 intracerebral hemorrhage 0.00010814697890307 0.00139464318585728 1.54141692789969 0.727272727272727 19.3 19 3 abnormal ear position 0.00676060572069957 0.0408675740710576 1.54141692789969 0.727272727272727 19.3 19 3 delayed hepatic development 0.00676060572069957 0.0408675740710576 1.54141692789969 0.727272727272727 19.3 19 3 abnormal sebaceous gland morphology 0.00676060572069957 0.0408675740710576 1.54141692789969 0.727272727272727 19.3 19 3 fused joints 0.00676060572069957 0.0408675740710576 1.54141692789969 0.727272727272727 19.3 19 3 abnormal spinal cord ventral horn morphology 0.00676060572069957 0.0408675740710576 1.54141692789969 0.727272727272727 19.3 19 3 cyclopia 0.00676060572069957 0.0408675740710576 1.54141692789969 0.727272727272727 19.3 19 3 abnormal Bruch membrane morphology 0.00676060572069957 0.0408675740710576 1.54141692789969 0.727272727272727 19.3 19 3 palatal shelf hypoplasia 0.00676060572069957 0.0408675740710576 1.54141692789969 0.727272727272727 19.3 19 3 abnormal palatal shelf elevation 0.00676060572069957 0.0408675740710576 1.54141692789969 0.727272727272727 19.3 19 3 common atrioventricular valve 0.00676060572069957 0.0408675740710576 1.54141692789969 0.727272727272727 19.3 19 3 thin hypoglossal nerve 0.00676060572069957 0.0408675740710576 1.54141692789969 0.727272727272727 19.3 19 3 small lung 3.54478641747715e-09 1.45746383693792e-07 1.53763894523327 0.725490196078431 19.3 19 3 blood in lymph vessels 9.75687432175664e-06 0.000179116050740735 1.53477288941736 0.724137931034483 19.3 19 3 pulmonary hypoplasia 1.7336638989642e-08 6.34189551275507e-07 1.53321790168745 0.723404255319149 19.3 19 3 abnormal bile duct morphology 0.000556326135092213 0.0054806386575916 1.53071264367816 0.722222222222222 19.3 19 3 decreased cellular sensitivity to gamma-irradiation 0.000556326135092213 0.0054806386575916 1.53071264367816 0.722222222222222 19.3 19 3 absent inner cell mass 0.000556326135092213 0.0054806386575916 1.53071264367816 0.722222222222222 19.3 19 3 small thoracic cage 0.000556326135092213 0.0054806386575916 1.53071264367816 0.722222222222222 19.3 19 3 increased gastrointestinal tumor incidence 0.000556326135092213 0.0054806386575916 1.53071264367816 0.722222222222222 19.3 19 3 abnormal double-strand DNA break repair 8.49408637659816e-08 2.67456200782126e-06 1.52797433841219 0.720930232558139 19.3 19 3 abnormal primitive streak morphology 4.90239623756596e-05 0.000717335920055608 1.52600275862069 0.72 19.3 19 3 abnormal vertebrae development 4.90239623756596e-05 0.000717335920055608 1.52600275862069 0.72 19.3 19 3 abnormal lung development 6.8803632004889e-14 6.84596138448645e-12 1.52101582150101 0.717647058823529 19.3 19 3 subcutaneous edema 2.22644646787826e-05 0.000369219039256477 1.51389162561576 0.714285714285714 19.3 19 3 extended life span 0.00291197043447659 0.0207848678787963 1.51389162561576 0.714285714285714 19.3 19 3 lysosomal protein accumulation 0.00291197043447659 0.0207848678787963 1.51389162561576 0.714285714285714 19.3 19 3 broad head 0.0383123662845293 0.147707312606176 1.51389162561576 0.714285714285714 19.3 19 3 decreased Schwann cell number 0.0383123662845293 0.147707312606176 1.51389162561576 0.714285714285714 19.3 19 3 abnormal circulating alanine transaminase level 0.0383123662845293 0.147707312606176 1.51389162561576 0.714285714285714 19.3 19 3 abnormal axial mesoderm 0.0383123662845293 0.147707312606176 1.51389162561576 0.714285714285714 19.3 19 3 absent amniotic folds 0.0383123662845293 0.147707312606176 1.51389162561576 0.714285714285714 19.3 19 3 abnormal gastrulation movements 0.0383123662845293 0.147707312606176 1.51389162561576 0.714285714285714 19.3 19 3 decreased lateral semicircular canal size 0.0383123662845293 0.147707312606176 1.51389162561576 0.714285714285714 19.3 19 3 anuria 0.0383123662845293 0.147707312606176 1.51389162561576 0.714285714285714 19.3 19 3 increased cell nucleus count 0.0383123662845293 0.147707312606176 1.51389162561576 0.714285714285714 19.3 19 3 abnormal cochlear nerve compound action potential 0.0383123662845293 0.147707312606176 1.51389162561576 0.714285714285714 19.3 19 3 abnormal thyroid hormone level 0.0383123662845293 0.147707312606176 1.51389162561576 0.714285714285714 19.3 19 3 abnormal body temperature 0.0383123662845293 0.147707312606176 1.51389162561576 0.714285714285714 19.3 19 3 retinal pigment epithelium atrophy 0.0383123662845293 0.147707312606176 1.51389162561576 0.714285714285714 19.3 19 3 decreased tidal volume 0.0383123662845293 0.147707312606176 1.51389162561576 0.714285714285714 19.3 19 3 postaxial polydactyly 0.0383123662845293 0.147707312606176 1.51389162561576 0.714285714285714 19.3 19 3 abnormal sperm annulus morphology 0.0383123662845293 0.147707312606176 1.51389162561576 0.714285714285714 19.3 19 3 abnormal cerebellum white matter morphology 0.0383123662845293 0.147707312606176 1.51389162561576 0.714285714285714 19.3 19 3 decreased DN2 thymocyte number 0.0383123662845293 0.147707312606176 1.51389162561576 0.714285714285714 19.3 19 3 decreased DN4 thymocyte number 0.0383123662845293 0.147707312606176 1.51389162561576 0.714285714285714 19.3 19 3 increased oligodendrocyte number 0.0383123662845293 0.147707312606176 1.51389162561576 0.714285714285714 19.3 19 3 decreased brain cholesterol level 0.0383123662845293 0.147707312606176 1.51389162561576 0.714285714285714 19.3 19 3 heart block 0.0383123662845293 0.147707312606176 1.51389162561576 0.714285714285714 19.3 19 3 thick mitral valve cusps 0.0383123662845293 0.147707312606176 1.51389162561576 0.714285714285714 19.3 19 3 ductus venosus stenosis 0.0383123662845293 0.147707312606176 1.51389162561576 0.714285714285714 19.3 19 3 fragmented Meckel's cartilage 0.0383123662845293 0.147707312606176 1.51389162561576 0.714285714285714 19.3 19 3 decreased collagen level 0.0383123662845293 0.147707312606176 1.51389162561576 0.714285714285714 19.3 19 3 abnormal postnatal growth/weight/body size 1.01299525817965e-05 0.000185281301817786 1.50412458286986 0.709677419354839 19.3 19 3 abnormal nursing 0.00011138659327058 0.00141364362632942 1.50127586206897 0.708333333333333 19.3 19 3 abnormal embryonic neuroepithelium morphology 1.82246367144059e-09 7.98793808983649e-08 1.49823067776457 0.706896551724138 19.3 19 3 abnormal direction of heart looping 4.61682703823904e-06 9.37498551642418e-05 1.49608113590264 0.705882352941177 19.3 19 3 hyperlipidemia 0.00127168963117818 0.0109837776304018 1.49608113590264 0.705882352941177 19.3 19 3 abnormal cranial suture morphology 0.00127168963117818 0.0109837776304018 1.49608113590264 0.705882352941177 19.3 19 3 abnormal ductus venosus valve morphology 0.00127168963117818 0.0109837776304018 1.49608113590264 0.705882352941177 19.3 19 3 abnormal maxilla morphology 8.76243089360432e-09 3.35331489966781e-07 1.49146360153257 0.703703703703704 19.3 19 3 decreased width of hypertrophic chondrocyte zone 2.10746469577327e-06 4.59852493924212e-05 1.48934203168686 0.702702702702703 19.3 19 3 abnormal cell nucleus morphology 9.14779833312339e-08 2.81439599953067e-06 1.48812325752018 0.702127659574468 19.3 19 3 perinatal lethality 9.63376731766709e-07 2.28837624762874e-05 1.48361379310345 0.7 19.3 19 3 abnormal brain vasculature morphology 2.26638153862859e-05 0.000371613310554788 1.48361379310345 0.7 19.3 19 3 abnormal basioccipital bone morphology 0.000560924904458419 0.00549330984189102 1.48361379310345 0.7 19.3 19 3 dilated vasculature 0.000560924904458419 0.00549330984189102 1.48361379310345 0.7 19.3 19 3 decreased muscle cell glucose uptake 0.000560924904458419 0.00549330984189102 1.48361379310345 0.7 19.3 19 3 absent maxillary shelf 0.0156519857929154 0.0779808999660853 1.48361379310345 0.7 19.3 19 3 kidney hemorrhage 0.0156519857929154 0.0779808999660853 1.48361379310345 0.7 19.3 19 3 enlarged testis 0.0156519857929154 0.0779808999660853 1.48361379310345 0.7 19.3 19 3 fused cornea and lens 0.0156519857929154 0.0779808999660853 1.48361379310345 0.7 19.3 19 3 alcohol preference 0.0156519857929154 0.0779808999660853 1.48361379310345 0.7 19.3 19 3 acrania 0.0156519857929154 0.0779808999660853 1.48361379310345 0.7 19.3 19 3 peritoneal inflammation 0.0156519857929154 0.0779808999660853 1.48361379310345 0.7 19.3 19 3 increased atrioventricular cushion size 0.0156519857929154 0.0779808999660853 1.48361379310345 0.7 19.3 19 3 increased heart rate variability 0.0156519857929154 0.0779808999660853 1.48361379310345 0.7 19.3 19 3 abnormal plasma membrane morphology 0.0156519857929154 0.0779808999660853 1.48361379310345 0.7 19.3 19 3 abnormal spinal cord dorsal column morphology 0.0156519857929154 0.0779808999660853 1.48361379310345 0.7 19.3 19 3 thick aortic valve 0.0156519857929154 0.0779808999660853 1.48361379310345 0.7 19.3 19 3 fusion of atlas and odontoid process 0.0156519857929154 0.0779808999660853 1.48361379310345 0.7 19.3 19 3 abnormal circadian temperature homeostasis 0.0156519857929154 0.0779808999660853 1.48361379310345 0.7 19.3 19 3 lethality during fetal growth through weaning, complete penetrance 0.0156519857929154 0.0779808999660853 1.48361379310345 0.7 19.3 19 3 failure to gastrulate 2.02067840515263e-07 5.58493059201906e-06 1.4743988005997 0.695652173913043 19.3 19 3 abnormal limb bone morphology 4.66502140402754e-06 9.43434206708822e-05 1.47183908045977 0.694444444444444 19.3 19 3 decreased birth body size 3.79413829633145e-16 5.89869938257781e-14 1.46874047186933 0.692982456140351 19.3 19 3 abnormal telomere length 0.00660914340891693 0.0404932123883765 1.46731034482759 0.692307692307692 19.3 19 3 decreased endocochlear potential 0.00660914340891693 0.0404932123883765 1.46731034482759 0.692307692307692 19.3 19 3 abnormal vertebral arch development 0.00660914340891693 0.0404932123883765 1.46731034482759 0.692307692307692 19.3 19 3 abnormal head morphology 1.9561180807819e-08 7.00121399416544e-07 1.4643460815047 0.690909090909091 19.3 19 3 lethality at weaning, complete penetrance 4.42413176372755e-07 1.13453894456415e-05 1.46006436781609 0.688888888888889 19.3 19 3 decreased caudal vertebrae number 1.90718176435884e-09 8.17950799800451e-08 1.45712068965517 0.6875 19.3 19 3 abnormal auditory brainstem response waveform shape 2.25729908294518e-05 0.000371613310554788 1.45712068965517 0.6875 19.3 19 3 increased fibroblast apoptosis 2.25729908294518e-05 0.000371613310554788 1.45712068965517 0.6875 19.3 19 3 abnormal hair follicle orientation 0.00284769868829853 0.0204729782865393 1.45712068965517 0.6875 19.3 19 3 white spotting 0.00284769868829853 0.0204729782865393 1.45712068965517 0.6875 19.3 19 3 impaired behavioral response to addictive substance 0.00284769868829853 0.0204729782865393 1.45712068965517 0.6875 19.3 19 3 impaired somite development 0.00284769868829853 0.0204729782865393 1.45712068965517 0.6875 19.3 19 3 abnormal thoracic cage shape 0.00284769868829853 0.0204729782865393 1.45712068965517 0.6875 19.3 19 3 decreased midbrain size 0.00284769868829853 0.0204729782865393 1.45712068965517 0.6875 19.3 19 3 abnormal cell cycle 8.3103017559828e-16 1.1812500353147e-13 1.4559688155922 0.68695652173913 19.3 19 3 rib fusion 8.78903256692191e-10 4.12504122834307e-08 1.45514359238291 0.686567164179104 19.3 19 3 abnormal extraembryonic tissue morphology 3.88542527839628e-14 4.02708140833781e-12 1.45452332657201 0.686274509803922 19.3 19 3 abnormal midbrain development 1.02117760380936e-05 0.000185414546677064 1.45333596059113 0.685714285714286 19.3 19 3 abnormal embryonic epiblast morphology 1.02117760380936e-05 0.000185414546677064 1.45333596059113 0.685714285714286 19.3 19 3 abnormal nasal septum morphology 0.00124390299387666 0.0108966488659335 1.45014882032668 0.684210526315789 19.3 19 3 abnormal metatarsal bone morphology 0.00124390299387666 0.0108966488659335 1.45014882032668 0.684210526315789 19.3 19 3 abnormal cell morphology 1.79361672461147e-15 2.28801107819027e-13 1.45014882032668 0.684210526315789 19.3 19 3 abnormal basisphenoid bone morphology 0.000548754545380685 0.00546010772653781 1.44507836990596 0.681818181818182 19.3 19 3 increased coping response 0.000548754545380685 0.00546010772653781 1.44507836990596 0.681818181818182 19.3 19 3 abnormal sternum morphology 8.73515628458918e-10 4.12504122834307e-08 1.44368215892054 0.681159420289855 19.3 19 3 microcephaly 8.73515628458918e-10 4.12504122834307e-08 1.44368215892054 0.681159420289855 19.3 19 3 abnormal cochlear outer hair cell morphology 0.000243907183922285 0.00275781418184856 1.44122482758621 0.68 19.3 19 3 enlarged kidney 9.16446536530589e-08 2.81439599953067e-06 1.43962524398178 0.679245283018868 19.3 19 3 atrioventricular septal defect 9.16446536530589e-08 2.81439599953067e-06 1.43962524398178 0.679245283018868 19.3 19 3 myoclonus 0.000109048482271052 0.00139464318585728 1.43819704433498 0.678571428571429 19.3 19 3 abnormal jaw morphology 0.000109048482271052 0.00139464318585728 1.43819704433498 0.678571428571429 19.3 19 3 small superior cervical ganglion 0.000109048482271052 0.00139464318585728 1.43819704433498 0.678571428571429 19.3 19 3 abnormal somite shape 0.000109048482271052 0.00139464318585728 1.43819704433498 0.678571428571429 19.3 19 3 premature aging 0.000109048482271052 0.00139464318585728 1.43819704433498 0.678571428571429 19.3 19 3 abnormal brainstem morphology 0.000109048482271052 0.00139464318585728 1.43819704433498 0.678571428571429 19.3 19 3 pericardial effusion 8.84855138373451e-09 3.36042314000604e-07 1.4357552836485 0.67741935483871 19.3 19 3 impaired synaptic plasticity 2.20894423722855e-05 0.000367541725090703 1.43374442190669 0.676470588235294 19.3 19 3 short snout 3.80353953310711e-14 4.0260870589804e-12 1.43259003831418 0.675925925925926 19.3 19 3 kidney cysts 3.96604727133375e-10 2.07055235731748e-08 1.43205964585275 0.675675675675676 19.3 19 3 abnormal snout morphology 1.95928082212979e-07 5.44548720117079e-06 1.42655172413793 0.673076923076923 19.3 19 3 kinked neural tube 1.95928082212979e-07 5.44548720117079e-06 1.42655172413793 0.673076923076923 19.3 19 3 double outlet right ventricle 8.07857155130487e-14 7.88056734661603e-12 1.42617080244924 0.672897196261682 19.3 19 3 embryonic lethality between somite formation and embryo turning, complete penetrance 1.83040189395248e-09 7.98793808983649e-08 1.42305812807882 0.671428571428571 19.3 19 3 decreased cell proliferation 1.64689099693821e-22 4.55182372764866e-20 1.42060316868593 0.67027027027027 19.3 19 3 embryonic lethality, complete penetrance 3.00714156941586e-37 1.66228103420488e-34 1.41518019673549 0.667711598746082 19.3 19 3 abnormal chondrocyte morphology 1.89914421261937e-07 5.36831957828488e-06 1.41296551724138 0.666666666666667 19.3 19 3 abnormal cell adhesion 1.89914421261937e-07 5.36831957828488e-06 1.41296551724138 0.666666666666667 19.3 19 3 thin epidermis 0.00023401911195431 0.00266417638895353 1.41296551724138 0.666666666666667 19.3 19 3 increased embryonic tissue cell apoptosis 3.77174250709203e-10 1.9962147843386e-08 1.41296551724138 0.666666666666667 19.3 19 3 delayed bone ossification 8.18726979757453e-10 3.95453080028479e-08 1.41296551724138 0.666666666666667 19.3 19 3 abnormal digit morphology 1.77828446187357e-09 7.89907606948304e-08 1.41296551724138 0.666666666666667 19.3 19 3 decreased brain weight 8.69725068742605e-08 2.72130957043677e-06 1.41296551724138 0.666666666666667 19.3 19 3 abnormal myocardial trabeculae morphology 1.99411103184529e-06 4.3896913201019e-05 1.41296551724138 0.666666666666667 19.3 19 3 reduced long term depression 2.13052853062257e-05 0.000355683873820379 1.41296551724138 0.666666666666667 19.3 19 3 decreased brown adipose tissue amount 4.7179508489847e-05 0.000704859023234201 1.41296551724138 0.666666666666667 19.3 19 3 abnormal sensory capabilities/reflexes/nociception 0.000525093934931211 0.0052881423608963 1.41296551724138 0.666666666666667 19.3 19 3 increased body temperature 0.000525093934931211 0.0052881423608963 1.41296551724138 0.666666666666667 19.3 19 3 absent segment of posterior cerebral artery 0.00118609412235609 0.010481027102525 1.41296551724138 0.666666666666667 19.3 19 3 lowered ear position 0.00270241662335011 0.0199473630581109 1.41296551724138 0.666666666666667 19.3 19 3 abnormal heart shape 0.00270241662335011 0.0199473630581109 1.41296551724138 0.666666666666667 19.3 19 3 abnormal metacarpal bone morphology 0.00270241662335011 0.0199473630581109 1.41296551724138 0.666666666666667 19.3 19 3 abnormal eye anterior chamber morphology 0.00270241662335011 0.0199473630581109 1.41296551724138 0.666666666666667 19.3 19 3 abnormal pregnancy 0.00270241662335011 0.0199473630581109 1.41296551724138 0.666666666666667 19.3 19 3 decreased tumor latency 0.00270241662335011 0.0199473630581109 1.41296551724138 0.666666666666667 19.3 19 3 increased effector memory CD4-positive, alpha-beta T cell number 0.00270241662335011 0.0199473630581109 1.41296551724138 0.666666666666667 19.3 19 3 increased adipocyte glucose uptake 0.00270241662335011 0.0199473630581109 1.41296551724138 0.666666666666667 19.3 19 3 absent incisors 0.00622915558082728 0.0387375612682697 1.41296551724138 0.666666666666667 19.3 19 3 decreased hepatocyte number 0.00622915558082728 0.0387375612682697 1.41296551724138 0.666666666666667 19.3 19 3 audiogenic seizures 0.00622915558082728 0.0387375612682697 1.41296551724138 0.666666666666667 19.3 19 3 absent egg cylinders 0.00622915558082728 0.0387375612682697 1.41296551724138 0.666666666666667 19.3 19 3 abnormal trophectoderm morphology 0.00622915558082728 0.0387375612682697 1.41296551724138 0.666666666666667 19.3 19 3 abnormal cerebral aqueduct morphology 0.00622915558082728 0.0387375612682697 1.41296551724138 0.666666666666667 19.3 19 3 abnormal coronary vessel morphology 0.00622915558082728 0.0387375612682697 1.41296551724138 0.666666666666667 19.3 19 3 abnormal supraoccipital bone morphology 0.014596440834618 0.075918763318219 1.41296551724138 0.666666666666667 19.3 19 3 abnormal mating frequency 0.014596440834618 0.075918763318219 1.41296551724138 0.666666666666667 19.3 19 3 abnormal embryonic growth/weight/body size 0.014596440834618 0.075918763318219 1.41296551724138 0.666666666666667 19.3 19 3 small thyroid gland 0.014596440834618 0.075918763318219 1.41296551724138 0.666666666666667 19.3 19 3 small intestinal inflammation 0.014596440834618 0.075918763318219 1.41296551724138 0.666666666666667 19.3 19 3 increased osteosarcoma incidence 0.014596440834618 0.075918763318219 1.41296551724138 0.666666666666667 19.3 19 3 abnormal nucleotide metabolism 0.014596440834618 0.075918763318219 1.41296551724138 0.666666666666667 19.3 19 3 decreased left ventricle systolic pressure 0.014596440834618 0.075918763318219 1.41296551724138 0.666666666666667 19.3 19 3 abnormal cochlear outer hair cell physiology 0.014596440834618 0.075918763318219 1.41296551724138 0.666666666666667 19.3 19 3 hematuria 0.014596440834618 0.075918763318219 1.41296551724138 0.666666666666667 19.3 19 3 decreased mammary gland epithelial cell proliferation 0.014596440834618 0.075918763318219 1.41296551724138 0.666666666666667 19.3 19 3 increased skeletal muscle glycogen level 0.014596440834618 0.075918763318219 1.41296551724138 0.666666666666667 19.3 19 3 persistent right dorsal aorta 0.014596440834618 0.075918763318219 1.41296551724138 0.666666666666667 19.3 19 3 embryonic lethality between implantation and placentation, incomplete penetrance 0.014596440834618 0.075918763318219 1.41296551724138 0.666666666666667 19.3 19 3 distorted hair follicle pattern 0.0350723174368928 0.141397714139823 1.41296551724138 0.666666666666667 19.3 19 3 abnormal head movements 0.0350723174368928 0.141397714139823 1.41296551724138 0.666666666666667 19.3 19 3 synostosis 0.0350723174368928 0.141397714139823 1.41296551724138 0.666666666666667 19.3 19 3 thick tail 0.0350723174368928 0.141397714139823 1.41296551724138 0.666666666666667 19.3 19 3 abnormal kindling response 0.0350723174368928 0.141397714139823 1.41296551724138 0.666666666666667 19.3 19 3 abnormal ion homeostasis 0.0350723174368928 0.141397714139823 1.41296551724138 0.666666666666667 19.3 19 3 abnormal germ cell morphology 0.0350723174368928 0.141397714139823 1.41296551724138 0.666666666666667 19.3 19 3 abnormal NMDA-mediated synaptic currents 0.0350723174368928 0.141397714139823 1.41296551724138 0.666666666666667 19.3 19 3 genetic imprinting 0.0350723174368928 0.141397714139823 1.41296551724138 0.666666666666667 19.3 19 3 biliary cyst 0.0350723174368928 0.141397714139823 1.41296551724138 0.666666666666667 19.3 19 3 abnormal thymus physiology 0.0350723174368928 0.141397714139823 1.41296551724138 0.666666666666667 19.3 19 3 decreased muscle weight 0.0350723174368928 0.141397714139823 1.41296551724138 0.666666666666667 19.3 19 3 small scapula 0.0350723174368928 0.141397714139823 1.41296551724138 0.666666666666667 19.3 19 3 decreased cochlear hair cell number 0.0350723174368928 0.141397714139823 1.41296551724138 0.666666666666667 19.3 19 3 liver hyperplasia 0.0350723174368928 0.141397714139823 1.41296551724138 0.666666666666667 19.3 19 3 abnormal posterior eye segment morphology 0.0350723174368928 0.141397714139823 1.41296551724138 0.666666666666667 19.3 19 3 abnormal intervertebral disk development 0.0350723174368928 0.141397714139823 1.41296551724138 0.666666666666667 19.3 19 3 positive geotaxis 0.0350723174368928 0.141397714139823 1.41296551724138 0.666666666666667 19.3 19 3 abnormal leukopoiesis 0.0350723174368928 0.141397714139823 1.41296551724138 0.666666666666667 19.3 19 3 abnormal optic chiasm morphology 0.0350723174368928 0.141397714139823 1.41296551724138 0.666666666666667 19.3 19 3 abnormal retinal development 0.0350723174368928 0.141397714139823 1.41296551724138 0.666666666666667 19.3 19 3 eye opacity 0.0350723174368928 0.141397714139823 1.41296551724138 0.666666666666667 19.3 19 3 decreased transitional stage T1 B cell number 0.0350723174368928 0.141397714139823 1.41296551724138 0.666666666666667 19.3 19 3 abnormal cerebellar layer morphology 0.0350723174368928 0.141397714139823 1.41296551724138 0.666666666666667 19.3 19 3 abnormal incisor color 0.0350723174368928 0.141397714139823 1.41296551724138 0.666666666666667 19.3 19 3 abnormal ventricle myocardium morphology 0.0350723174368928 0.141397714139823 1.41296551724138 0.666666666666667 19.3 19 3 decreased effector memory CD4-positive, alpha-beta T cell number 0.0350723174368928 0.141397714139823 1.41296551724138 0.666666666666667 19.3 19 3 abnormal pulmonary alveolar system morphology 0.0350723174368928 0.141397714139823 1.41296551724138 0.666666666666667 19.3 19 3 abnormal oxidative phosphorylation 0.0350723174368928 0.141397714139823 1.41296551724138 0.666666666666667 19.3 19 3 decreased pancreatic beta cell proliferation 0.0350723174368928 0.141397714139823 1.41296551724138 0.666666666666667 19.3 19 3 trigeminal neuroma 0.0350723174368928 0.141397714139823 1.41296551724138 0.666666666666667 19.3 19 3 abnormal ductus venosus valve topology 0.0350723174368928 0.141397714139823 1.41296551724138 0.666666666666667 19.3 19 3 abnormal coronary sinus connection 0.0350723174368928 0.141397714139823 1.41296551724138 0.666666666666667 19.3 19 3 decreased platelet dense granule number 0.0350723174368928 0.141397714139823 1.41296551724138 0.666666666666667 19.3 19 3 lethality throughout fetal growth and development, incomplete penetrance 3.30385980895737e-21 7.82700121407757e-19 1.40901868618763 0.664804469273743 19.3 19 3 neuron degeneration 1.91007399800418e-06 4.22338584003147e-05 1.39793396918562 0.659574468085106 19.3 19 3 palatal shelves fail to meet at midline 9.21394098989062e-06 0.000171393369718044 1.39573423044575 0.658536585365854 19.3 19 3 abnormal axial skeleton morphology 1.64697631541701e-09 7.38171817045009e-08 1.39437386569873 0.657894736842105 19.3 19 3 decreased triglyceride level 4.48549695128199e-05 0.00067622264644327 1.3927802955665 0.657142857142857 19.3 19 3 decreased glycogen level 4.48549695128199e-05 0.00067622264644327 1.3927802955665 0.657142857142857 19.3 19 3 abnormal hippocampus pyramidal cell morphology 4.48549695128199e-05 0.00067622264644327 1.3927802955665 0.657142857142857 19.3 19 3 abnormal lumbar vertebrae morphology 9.94077150367602e-05 0.00130145626923127 1.39088793103448 0.65625 19.3 19 3 abnormal spongiotrophoblast layer morphology 9.94077150367602e-05 0.00130145626923127 1.39088793103448 0.65625 19.3 19 3 lordosis 0.000221128289744477 0.00253482313704786 1.38860404280618 0.655172413793103 19.3 19 3 absent long term depression 0.000221128289744477 0.00253482313704786 1.38860404280618 0.655172413793103 19.3 19 3 short sternum 0.000221128289744477 0.00253482313704786 1.38860404280618 0.655172413793103 19.3 19 3 ventricular septal defect 1.35501164622101e-15 1.87255081665264e-13 1.38699188640974 0.654411764705882 19.3 19 3 increased neuron apoptosis 7.25109359673633e-10 3.60741906437632e-08 1.38679948914432 0.654320987654321 19.3 19 3 abnormal placenta vasculature 8.29480184962607e-07 1.99355744936665e-05 1.38579310344828 0.653846153846154 19.3 19 3 ventricular hypoplasia 0.000494111789204474 0.0050065298396991 1.38579310344828 0.653846153846154 19.3 19 3 abnormal Schwann cell morphology 0.000494111789204474 0.0050065298396991 1.38579310344828 0.653846153846154 19.3 19 3 increased thymocyte apoptosis 0.000494111789204474 0.0050065298396991 1.38579310344828 0.653846153846154 19.3 19 3 abnormal neurocranium morphology 3.40836412761818e-09 1.41305096124171e-07 1.38470620689655 0.653333333333333 19.3 19 3 hydrops fetalis 7.39537062791213e-09 2.85222860000327e-07 1.38352873563218 0.652777777777778 19.3 19 3 abnormal locomotor behavior 6.80286422549982e-11 4.02907732403114e-09 1.38224887556222 0.652173913043478 19.3 19 3 atrial septal defect 3.97220633440853e-06 8.16600269160431e-05 1.38224887556222 0.652173913043478 19.3 19 3 abnormal pulmonary artery morphology 0.00111025236704924 0.00997022658135371 1.38224887556222 0.652173913043478 19.3 19 3 abnormal cranial nerve morphology 0.00111025236704924 0.00997022658135371 1.38224887556222 0.652173913043478 19.3 19 3 abnormal basicranium morphology 0.00111025236704924 0.00997022658135371 1.38224887556222 0.652173913043478 19.3 19 3 abnormal vertebral artery topology 0.00111025236704924 0.00997022658135371 1.38224887556222 0.652173913043478 19.3 19 3 prenatal lethality, incomplete penetrance 1.81195668151858e-32 7.51207040879578e-30 1.38043012704174 0.651315789473684 19.3 19 3 abnormal vasculogenesis 8.71370661387804e-06 0.000164207160621376 1.38010585404972 0.651162790697674 19.3 19 3 delayed endochondral bone ossification 8.71370661387804e-06 0.000164207160621376 1.38010585404972 0.651162790697674 19.3 19 3 gliosis 7.58340317515928e-08 2.4307138677083e-06 1.37932348111658 0.650793650793651 19.3 19 3 absent mesoderm 1.65000699775968e-07 4.80045895547041e-06 1.37764137931034 0.65 19.3 19 3 abnormal circulating enzyme level 0.00251229087422482 0.0190819039683488 1.37764137931034 0.65 19.3 19 3 increased mammary adenocarcinoma incidence 0.00251229087422482 0.0190819039683488 1.37764137931034 0.65 19.3 19 3 decreased myocardial infarction size 0.00251229087422482 0.0190819039683488 1.37764137931034 0.65 19.3 19 3 abnormal physiological neovascularization 0.00251229087422482 0.0190819039683488 1.37764137931034 0.65 19.3 19 3 abnormal postnatal subventricular zone morphology 0.00251229087422482 0.0190819039683488 1.37764137931034 0.65 19.3 19 3 abnormal sperm mitochondrial sheath morphology 0.00251229087422482 0.0190819039683488 1.37764137931034 0.65 19.3 19 3 incomplete embryo turning 3.59330589006171e-07 9.40878779108264e-06 1.37578221415608 0.649122807017544 19.3 19 3 increased cell proliferation 7.83309036532885e-07 1.89172934793743e-05 1.37371647509579 0.648148148148148 19.3 19 3 abnormal mandible morphology 7.83309036532885e-07 1.89172934793743e-05 1.37371647509579 0.648148148148148 19.3 19 3 short maxilla 9.31779630387103e-05 0.00122964392781963 1.37140770791075 0.647058823529412 19.3 19 3 enlarged liver sinusoidal spaces 9.31779630387103e-05 0.00122964392781963 1.37140770791075 0.647058823529412 19.3 19 3 abnormal vagus nerve morphology 0.00573704862635248 0.0365920729693636 1.37140770791075 0.647058823529412 19.3 19 3 abnormal glutamate-mediated receptor currents 0.00573704862635248 0.0365920729693636 1.37140770791075 0.647058823529412 19.3 19 3 absence seizures 0.00573704862635248 0.0365920729693636 1.37140770791075 0.647058823529412 19.3 19 3 abnormal embryonic-extraembryonic boundary morphology 0.00573704862635248 0.0365920729693636 1.37140770791075 0.647058823529412 19.3 19 3 abnormal ectoplacental cone morphology 0.00573704862635248 0.0365920729693636 1.37140770791075 0.647058823529412 19.3 19 3 abnormal tarsal bone morphology 0.00573704862635248 0.0365920729693636 1.37140770791075 0.647058823529412 19.3 19 3 enhanced behavioral response to cocaine 0.00573704862635248 0.0365920729693636 1.37140770791075 0.647058823529412 19.3 19 3 increased hepatoma incidence 0.00573704862635248 0.0365920729693636 1.37140770791075 0.647058823529412 19.3 19 3 abnormal gastrulation 1.7094368851643e-06 3.8308326593209e-05 1.37140770791075 0.647058823529412 19.3 19 3 abnormal gluconeogenesis 1.7094368851643e-06 3.8308326593209e-05 1.37140770791075 0.647058823529412 19.3 19 3 thymus atrophy 3.73518835435272e-06 7.84074348645772e-05 1.36881034482759 0.645833333333333 19.3 19 3 prenatal lethality 1.55407951510711e-07 4.57487904595142e-06 1.36738598442714 0.645161290322581 19.3 19 3 inner cell mass degeneration 0.000206422011161953 0.00242205072059131 1.36738598442714 0.645161290322581 19.3 19 3 abnormal cell migration 8.17296874487679e-06 0.0001563866134837 1.36586666666667 0.644444444444444 19.3 19 3 preweaning lethality, complete penetrance 6.19258450226184e-74 1.54040539493763e-70 1.36332078285182 0.643243243243243 19.3 19 3 abnormal eye development 7.34954300192675e-07 1.801181105152e-05 1.36250246305419 0.642857142857143 19.3 19 3 lymphoid hyperplasia 0.000458966245384174 0.00475699389747139 1.36250246305419 0.642857142857143 19.3 19 3 abnormal maternal decidual layer morphology 0.0132640547629095 0.0711084832386582 1.36250246305419 0.642857142857143 19.3 19 3 decreased CNS synapse formation 0.0132640547629095 0.0711084832386582 1.36250246305419 0.642857142857143 19.3 19 3 abnormal viscerocranium morphology 0.0132640547629095 0.0711084832386582 1.36250246305419 0.642857142857143 19.3 19 3 testis degeneration 0.0132640547629095 0.0711084832386582 1.36250246305419 0.642857142857143 19.3 19 3 abnormal cranium morphology 2.2314591907807e-14 2.41337162481173e-12 1.36024292331446 0.641791044776119 19.3 19 3 increased circulating alanine transaminase level 6.19891051359128e-09 2.44758569881878e-07 1.35862068965517 0.641025641025641 19.3 19 3 anophthalmia 5.76652560504641e-10 2.92739437603121e-08 1.35739945757458 0.640449438202247 19.3 19 3 mandible hypoplasia 0.00102498149228041 0.00935648242953222 1.35644689655172 0.64 19.3 19 3 short radius 8.65197954167938e-05 0.0011825164346114 1.35409195402299 0.638888888888889 19.3 19 3 decreased embryo size 1.46916021217313e-46 9.13634006945168e-44 1.35236762371952 0.638075313807531 19.3 19 3 abnormal embryo turning 1.48939957334886e-06 3.39897379697733e-05 1.34873981191223 0.636363636363636 19.3 19 3 omphalocele 1.6628376305438e-05 0.000287243653192896 1.34873981191223 0.636363636363636 19.3 19 3 increased cardiomyocyte apoptosis 0.000190807076493857 0.00228188751335802 1.34873981191223 0.636363636363636 19.3 19 3 abnormal abdominal fat pad morphology 0.00230143838206305 0.0178621777703022 1.34873981191223 0.636363636363636 19.3 19 3 abnormal enterocyte morphology 0.00230143838206305 0.0178621777703022 1.34873981191223 0.636363636363636 19.3 19 3 abnormal germ layer development 0.00230143838206305 0.0178621777703022 1.34873981191223 0.636363636363636 19.3 19 3 abnormal chorion morphology 0.00230143838206305 0.0178621777703022 1.34873981191223 0.636363636363636 19.3 19 3 abnormal vascular branching morphogenesis 0.00230143838206305 0.0178621777703022 1.34873981191223 0.636363636363636 19.3 19 3 prolonged PR interval 0.00230143838206305 0.0178621777703022 1.34873981191223 0.636363636363636 19.3 19 3 abnormal limb posture 0.00230143838206305 0.0178621777703022 1.34873981191223 0.636363636363636 19.3 19 3 abnormal sphenoid bone morphology 0.0312119009192931 0.13729372862377 1.34873981191223 0.636363636363636 19.3 19 3 abnormal food preference 0.0312119009192931 0.13729372862377 1.34873981191223 0.636363636363636 19.3 19 3 impaired myelopoiesis 0.0312119009192931 0.13729372862377 1.34873981191223 0.636363636363636 19.3 19 3 aorta dilation 0.0312119009192931 0.13729372862377 1.34873981191223 0.636363636363636 19.3 19 3 pale liver 2.70008091399441e-08 9.39363814484068e-07 1.34613606710158 0.635135135135135 19.3 19 3 liver hypoplasia 3.23778273288301e-06 6.88374747696282e-05 1.34503448275862 0.634615384615385 19.3 19 3 lethality at weaning, incomplete penetrance 3.6378156132906e-05 0.000565566646128773 1.34404037005887 0.634146341463415 19.3 19 3 abnormal incisor morphology 6.36341121717934e-07 1.59085280429484e-05 1.34231724137931 0.633333333333333 19.3 19 3 delayed eyelid opening 0.000421973128342357 0.00441702017881458 1.34231724137931 0.633333333333333 19.3 19 3 abnormal lactation 0.000421973128342357 0.00441702017881458 1.34231724137931 0.633333333333333 19.3 19 3 abnormal optic cup morphology 0.000421973128342357 0.00441702017881458 1.34231724137931 0.633333333333333 19.3 19 3 embryonic growth arrest 2.21921794203085e-22 5.81084697979131e-20 1.34200873362445 0.633187772925764 19.3 19 3 polydactyly 2.17314890819457e-10 1.2147658222773e-08 1.3408754398311 0.63265306122449 19.3 19 3 abnormal long bone hypertrophic chondrocyte zone 7.04420034753726e-06 0.000135832933058131 1.3408754398311 0.63265306122449 19.3 19 3 embryonic lethality before implantation, complete penetrance 8.32224523151485e-13 6.46924531668537e-11 1.33949131034483 0.632 19.3 19 3 small superior vagus ganglion 0.00520272570244744 0.0342828614167894 1.33859891107078 0.631578947368421 19.3 19 3 delayed sexual maturation 0.00520272570244744 0.0342828614167894 1.33859891107078 0.631578947368421 19.3 19 3 increased susceptibility to ischemic brain injury 0.00520272570244744 0.0342828614167894 1.33859891107078 0.631578947368421 19.3 19 3 abnormal digestive system development 0.00520272570244744 0.0342828614167894 1.33859891107078 0.631578947368421 19.3 19 3 maternal imprinting 0.00520272570244744 0.0342828614167894 1.33859891107078 0.631578947368421 19.3 19 3 abnormal sternebra morphology 0.00520272570244744 0.0342828614167894 1.33859891107078 0.631578947368421 19.3 19 3 decreased eye pigmentation 0.00520272570244744 0.0342828614167894 1.33859891107078 0.631578947368421 19.3 19 3 increased liver cholesterol level 0.00520272570244744 0.0342828614167894 1.33859891107078 0.631578947368421 19.3 19 3 abnormal myelin sheath morphology 1.53389752097933e-05 0.000265893385605301 1.33617391304348 0.630434782608696 19.3 19 3 abnormal axon morphology 4.0593779609736e-11 2.52442566948045e-09 1.33446743295019 0.62962962962963 19.3 19 3 abnormal atrioventricular cushion morphology 0.000936269340529749 0.00865788098352323 1.33446743295019 0.62962962962963 19.3 19 3 abnormal fetal cardiomyocyte proliferation 0.000936269340529749 0.00865788098352323 1.33446743295019 0.62962962962963 19.3 19 3 decreased circulating fructosamine level 0.000936269340529749 0.00865788098352323 1.33446743295019 0.62962962962963 19.3 19 3 abnormal bone trabecula morphology 0.000936269340529749 0.00865788098352323 1.33446743295019 0.62962962962963 19.3 19 3 thick pulmonary interalveolar septum 0.00017495533669791 0.00211776837000512 1.33222463054187 0.628571428571429 19.3 19 3 abnormal dermal layer morphology 0.00017495533669791 0.00211776837000512 1.33222463054187 0.628571428571429 19.3 19 3 holoprosencephaly 0.00017495533669791 0.00211776837000512 1.33222463054187 0.628571428571429 19.3 19 3 increased rib number 2.31636874793346e-08 8.17300320636097e-07 1.33144827586207 0.628205128205128 19.3 19 3 small liver 2.31636874793346e-08 8.17300320636097e-07 1.33144827586207 0.628205128205128 19.3 19 3 abnormal left-right axis patterning 3.34331870544888e-05 0.000526361093658486 1.33081635926223 0.627906976744186 19.3 19 3 distended abdomen 6.48391432681109e-06 0.000126005756937051 1.32984989858012 0.627450980392157 19.3 19 3 failure of chorioallantoic fusion 6.48391432681109e-06 0.000126005756937051 1.32984989858012 0.627450980392157 19.3 19 3 abnormal thoracic vertebrae morphology 1.27058348508478e-06 2.95380973752185e-05 1.32914552893045 0.627118644067797 19.3 19 3 embryonic lethality during organogenesis, complete penetrance 9.41042575499219e-51 9.36337362621723e-48 1.32843990147783 0.626785714285714 19.3 19 3 postnatal lethality 5.21310290451395e-16 7.85914756059299e-14 1.32784711258828 0.626506024096386 19.3 19 3 abnormal neuron morphology 3.99543771462268e-10 2.07055235731748e-08 1.32733124346917 0.626262626262626 19.3 19 3 abnormal vitelline vasculature morphology 1.6207664524909e-11 1.09310447291854e-09 1.32695892053973 0.626086956521739 19.3 19 3 abnormal behavior 1.0317591434842e-25 3.66642981345278e-23 1.32656115107914 0.62589928057554 19.3 19 3 abnormal eye morphology 1.33829013819595e-13 1.18892739955801e-11 1.32656115107914 0.62589928057554 19.3 19 3 abnormal vertebral body morphology 0.000384779171370609 0.00408161274534921 1.32465517241379 0.625 19.3 19 3 kidney cortex cysts 0.000384779171370609 0.00408161274534921 1.32465517241379 0.625 19.3 19 3 increased fatty acid level 0.000384779171370609 0.00408161274534921 1.32465517241379 0.625 19.3 19 3 absent mandible 0.0118649170683752 0.0645820157715173 1.32465517241379 0.625 19.3 19 3 disorganized retinal layers 0.0118649170683752 0.0645820157715173 1.32465517241379 0.625 19.3 19 3 abnormal meiosis 0.0118649170683752 0.0645820157715173 1.32465517241379 0.625 19.3 19 3 increased intestinal adenocarcinoma incidence 0.0118649170683752 0.0645820157715173 1.32465517241379 0.625 19.3 19 3 abnormal epicardium morphology 0.0118649170683752 0.0645820157715173 1.32465517241379 0.625 19.3 19 3 small pancreas 0.0118649170683752 0.0645820157715173 1.32465517241379 0.625 19.3 19 3 bowed tibia 0.0118649170683752 0.0645820157715173 1.32465517241379 0.625 19.3 19 3 bowed radius 0.0118649170683752 0.0645820157715173 1.32465517241379 0.625 19.3 19 3 abnormal bone marrow development 0.0754673218959846 0.247495007536271 1.32465517241379 0.625 19.3 19 3 schistocytosis 0.0754673218959846 0.247495007536271 1.32465517241379 0.625 19.3 19 3 enlarged pituitary gland 0.0754673218959846 0.247495007536271 1.32465517241379 0.625 19.3 19 3 increased sensitivity to skin irradiation 0.0754673218959846 0.247495007536271 1.32465517241379 0.625 19.3 19 3 dry eyes 0.0754673218959846 0.247495007536271 1.32465517241379 0.625 19.3 19 3 poor grooming 0.0754673218959846 0.247495007536271 1.32465517241379 0.625 19.3 19 3 abnormal thyroid physiology 0.0754673218959846 0.247495007536271 1.32465517241379 0.625 19.3 19 3 decreased aerobic running capacity 0.0754673218959846 0.247495007536271 1.32465517241379 0.625 19.3 19 3 abnormal neuron apoptosis 0.0754673218959846 0.247495007536271 1.32465517241379 0.625 19.3 19 3 liver cysts 0.0754673218959846 0.247495007536271 1.32465517241379 0.625 19.3 19 3 increased left ventricle systolic pressure 0.0754673218959846 0.247495007536271 1.32465517241379 0.625 19.3 19 3 lymph node inflammation 0.0754673218959846 0.247495007536271 1.32465517241379 0.625 19.3 19 3 absent cochlear microphonics 0.0754673218959846 0.247495007536271 1.32465517241379 0.625 19.3 19 3 abnormal kidney epithelium morphology 0.0754673218959846 0.247495007536271 1.32465517241379 0.625 19.3 19 3 ocular hypertension 0.0754673218959846 0.247495007536271 1.32465517241379 0.625 19.3 19 3 abnormal ilium morphology 0.0754673218959846 0.247495007536271 1.32465517241379 0.625 19.3 19 3 choroidal neovascularization 0.0754673218959846 0.247495007536271 1.32465517241379 0.625 19.3 19 3 abnormal epidermal lamellar body morphology 0.0754673218959846 0.247495007536271 1.32465517241379 0.625 19.3 19 3 impaired behavioral response to alcohol 0.0754673218959846 0.247495007536271 1.32465517241379 0.625 19.3 19 3 abnormal olfactory bulb glomerular layer morphology 0.0754673218959846 0.247495007536271 1.32465517241379 0.625 19.3 19 3 abnormal olfactory bulb mitral cell layer morphology 0.0754673218959846 0.247495007536271 1.32465517241379 0.625 19.3 19 3 abnormal brain ependyma morphology 0.0754673218959846 0.247495007536271 1.32465517241379 0.625 19.3 19 3 decreased quadriceps weight 0.0754673218959846 0.247495007536271 1.32465517241379 0.625 19.3 19 3 pleural effusion 0.0754673218959846 0.247495007536271 1.32465517241379 0.625 19.3 19 3 anomalous pulmonary venous connection 0.0754673218959846 0.247495007536271 1.32465517241379 0.625 19.3 19 3 myocardial trabeculae hypoplasia 0.0754673218959846 0.247495007536271 1.32465517241379 0.625 19.3 19 3 abnormal visual evoked potential 0.0754673218959846 0.247495007536271 1.32465517241379 0.625 19.3 19 3 increased aorta wall thickness 0.0754673218959846 0.247495007536271 1.32465517241379 0.625 19.3 19 3 abnormal heart echocardiography feature 0.0754673218959846 0.247495007536271 1.32465517241379 0.625 19.3 19 3 increased cornea thickness 0.0754673218959846 0.247495007536271 1.32465517241379 0.625 19.3 19 3 increased testis apoptosis 0.0754673218959846 0.247495007536271 1.32465517241379 0.625 19.3 19 3 abnormal umbilical vein topology 0.0754673218959846 0.247495007536271 1.32465517241379 0.625 19.3 19 3 increased mammary gland apoptosis 0.0754673218959846 0.247495007536271 1.32465517241379 0.625 19.3 19 3 decreased white adipose tissue mass 0.0754673218959846 0.247495007536271 1.32465517241379 0.625 19.3 19 3 abnormal neuromuscular synapse morphology 1.07174926152368e-07 3.25119059517092e-06 1.32465517241379 0.625 19.3 19 3 abnormal forebrain development 1.07174926152368e-07 3.25119059517092e-06 1.32465517241379 0.625 19.3 19 3 overriding aortic valve 1.40713884724826e-05 0.000248245239895748 1.32465517241379 0.625 19.3 19 3 decreased body height 0.00208551642057927 0.0164951418002892 1.32465517241379 0.625 19.3 19 3 increased hemangiosarcoma incidence 0.00208551642057927 0.0164951418002892 1.32465517241379 0.625 19.3 19 3 abnormal lung saccule morphology 0.00208551642057927 0.0164951418002892 1.32465517241379 0.625 19.3 19 3 abnormal neural tube morphology 2.19050077400339e-15 2.72443533766672e-13 1.32138441890166 0.623456790123457 19.3 19 3 perimembraneous ventricular septal defect 2.30501922603896e-07 6.33561914339437e-06 1.3208155922039 0.623188405797101 19.3 19 3 increased insulin sensitivity 1.13725881423298e-13 1.02870229105619e-11 1.31909717868339 0.622377622377622 19.3 19 3 abnormal breathing pattern 0.000159348933128547 0.00194781558308236 1.31749487418453 0.621621621621622 19.3 19 3 abnormal chromosome morphology 0.000159348933128547 0.00194781558308236 1.31749487418453 0.621621621621622 19.3 19 3 abnormal craniofacial morphology 3.38345571336044e-10 1.80996690042669e-08 1.31693873451624 0.621359223300971 19.3 19 3 abnormal parietal bone morphology 0.000848155627340047 0.007961460841541 1.31551961950059 0.620689655172414 19.3 19 3 decreased body length 1.54026670281624e-24 5.1085512310072e-22 1.31498615655676 0.62043795620438 19.3 19 3 abnormal somite development 4.20097639451104e-08 1.40267500420754e-06 1.31459450021825 0.620253164556962 19.3 19 3 kyphosis 4.51058661831328e-14 4.57962620940991e-12 1.31405793103448 0.62 19.3 19 3 increased B cell derived lymphoma incidence 1.28461547550519e-05 0.000228248642522797 1.31405793103448 0.62 19.3 19 3 perinatal lethality, complete penetrance 2.53181585337442e-19 4.84453225789914e-17 1.31346090335114 0.619718309859155 19.3 19 3 abnormal pancreas morphology 6.63862240093293e-05 0.000929375830315379 1.312039408867 0.619047619047619 19.3 19 3 abnormal eye pigmentation 0.00466736059601151 0.0311679449196742 1.312039408867 0.619047619047619 19.3 19 3 liver degeneration 0.00466736059601151 0.0311679449196742 1.312039408867 0.619047619047619 19.3 19 3 complete atrioventricular septal defect 0.00466736059601151 0.0311679449196742 1.312039408867 0.619047619047619 19.3 19 3 decreased circulating total protein level 5.4177436616136e-06 0.000108246083198906 1.31020438871473 0.618181818181818 19.3 19 3 overexpanded pulmonary alveoli 0.000348515644382941 0.00376927245827202 1.30907099391481 0.617647058823529 19.3 19 3 abnormal nervous system development 0.000348515644382941 0.00376927245827202 1.30907099391481 0.617647058823529 19.3 19 3 impaired balance 6.61546055554408e-10 3.32443598624564e-08 1.30907099391481 0.617647058823529 19.3 19 3 abnormal nervous system physiology 5.72712793259494e-11 3.47469042251949e-09 1.30852893553223 0.617391304347826 19.3 19 3 decreased bone marrow cell number 1.92636078215833e-07 5.41448863911734e-06 1.30650921114785 0.616438356164384 19.3 19 3 embryonic lethality between implantation and somite formation, complete penetrance 1.49487384821669e-21 3.71849869743901e-19 1.30627220267417 0.616326530612245 19.3 19 3 absent gastric milk in neonates 8.20779115543926e-08 2.60087649670766e-06 1.30427586206897 0.615384615384615 19.3 19 3 increased hepatocyte apoptosis 0.000144320815434858 0.00179948886413137 1.30427586206897 0.615384615384615 19.3 19 3 abnormal xiphoid process morphology 0.00187437301720192 0.0153624477110042 1.30427586206897 0.615384615384615 19.3 19 3 heart inflammation 0.00187437301720192 0.0153624477110042 1.30427586206897 0.615384615384615 19.3 19 3 absent teeth 0.0273761167157397 0.123254462136475 1.30427586206897 0.615384615384615 19.3 19 3 absent myocardial trabeculae 0.0273761167157397 0.123254462136475 1.30427586206897 0.615384615384615 19.3 19 3 abnormal grip strength 0.0273761167157397 0.123254462136475 1.30427586206897 0.615384615384615 19.3 19 3 increased pituitary adenoma incidence 0.0273761167157397 0.123254462136475 1.30427586206897 0.615384615384615 19.3 19 3 lymphoid hypoplasia 0.0273761167157397 0.123254462136475 1.30427586206897 0.615384615384615 19.3 19 3 abnormal lung interstitium morphology 0.0273761167157397 0.123254462136475 1.30427586206897 0.615384615384615 19.3 19 3 abnormal coping response 0.0273761167157397 0.123254462136475 1.30427586206897 0.615384615384615 19.3 19 3 anal atresia 0.0273761167157397 0.123254462136475 1.30427586206897 0.615384615384615 19.3 19 3 tracheoesophageal fistula 0.0273761167157397 0.123254462136475 1.30427586206897 0.615384615384615 19.3 19 3 increased circulating ammonia level 0.0273761167157397 0.123254462136475 1.30427586206897 0.615384615384615 19.3 19 3 increased circulating thyroxine level 0.0273761167157397 0.123254462136475 1.30427586206897 0.615384615384615 19.3 19 3 empty decidua capsularis 0.0273761167157397 0.123254462136475 1.30427586206897 0.615384615384615 19.3 19 3 abnormal aorta tunica media morphology 0.0273761167157397 0.123254462136475 1.30427586206897 0.615384615384615 19.3 19 3 abnormal vertebrae morphology 2.5924493498163e-10 1.4330483905929e-08 1.30278013286935 0.614678899082569 19.3 19 3 abnormal neural tube closure 3.50139023757915e-08 1.18499431509907e-06 1.30231159119236 0.614457831325301 19.3 19 3 increased hepatocellular carcinoma incidence 4.92305697512673e-06 9.87589050453849e-05 1.30141560798548 0.614035087719298 19.3 19 3 abnormal amino acid level 6.01231805970982e-05 0.000849734443971083 1.30057053291536 0.613636363636364 19.3 19 3 abnormal limb morphology 1.75325874328354e-07 5.07119898129976e-06 1.29992827586207 0.613333333333333 19.3 19 3 abnormal object recognition memory 0.000763262397211325 0.00723281985928827 1.29901668520578 0.612903225806452 19.3 19 3 decreased neuronal precursor cell number 0.000763262397211325 0.00723281985928827 1.29901668520578 0.612903225806452 19.3 19 3 increased T cell derived lymphoma incidence 2.51669486697649e-05 0.000405196018226797 1.29762139338494 0.612244897959184 19.3 19 3 prenatal lethality, complete penetrance 1.53619377588016e-23 4.4956259029434e-21 1.29606549243364 0.611510791366906 19.3 19 3 pallor 2.3039645861523e-15 2.79566434539212e-13 1.29589123152709 0.611428571428571 19.3 19 3 preweaning lethality, incomplete penetrance 6.59484903702098e-34 3.28093739591794e-31 1.29550628108928 0.611246943765281 19.3 19 3 impaired limb coordination 1.0575639488608e-05 0.000189941539551714 1.2952183908046 0.611111111111111 19.3 19 3 abnormal neuronal precursor proliferation 1.0575639488608e-05 0.000189941539551714 1.2952183908046 0.611111111111111 19.3 19 3 axon degeneration 1.0575639488608e-05 0.000189941539551714 1.2952183908046 0.611111111111111 19.3 19 3 abnormal trophoblast giant cell morphology 0.000313925472996807 0.00343248182012992 1.2952183908046 0.611111111111111 19.3 19 3 narrow eye opening 0.000313925472996807 0.00343248182012992 1.2952183908046 0.611111111111111 19.3 19 3 abnormal retinal blood vessel morphology 0.000313925472996807 0.00343248182012992 1.2952183908046 0.611111111111111 19.3 19 3 delayed kidney development 0.0105057560596419 0.0586153142745246 1.2952183908046 0.611111111111111 19.3 19 3 absent allantois 0.0105057560596419 0.0586153142745246 1.2952183908046 0.611111111111111 19.3 19 3 decreased activity of thyroid 0.0105057560596419 0.0586153142745246 1.2952183908046 0.611111111111111 19.3 19 3 darkened coat color 0.0105057560596419 0.0586153142745246 1.2952183908046 0.611111111111111 19.3 19 3 primary atelectasis 0.0105057560596419 0.0586153142745246 1.2952183908046 0.611111111111111 19.3 19 3 abnormal embryo development 3.445578492688e-12 2.44882185730326e-10 1.29348681541582 0.610294117647059 19.3 19 3 decreased double-positive T cell number 2.48479061413169e-09 1.05656694917138e-07 1.29286344827586 0.61 19.3 19 3 abnormal developmental patterning 6.77727669866879e-08 2.20372232522074e-06 1.29234650967199 0.609756097560976 19.3 19 3 decreased lymphocyte cell number 1.69767521509525e-11 1.11130713093406e-09 1.29153879310345 0.609375 19.3 19 3 thymus hypoplasia 3.13092373410283e-12 2.25744138799443e-10 1.29009895052474 0.608695652173913 19.3 19 3 abnormal cell death 5.42241928398495e-05 0.00077966866872327 1.29009895052474 0.608695652173913 19.3 19 3 embryonic lethality between implantation and placentation, complete penetrance 5.42241928398495e-05 0.00077966866872327 1.29009895052474 0.608695652173913 19.3 19 3 abnormal postnatal growth 0.00415439440541789 0.0282351259111393 1.29009895052474 0.608695652173913 19.3 19 3 abnormal nasal cavity morphology 0.00415439440541789 0.0282351259111393 1.29009895052474 0.608695652173913 19.3 19 3 abnormal Wolffian duct morphology 0.00415439440541789 0.0282351259111393 1.29009895052474 0.608695652173913 19.3 19 3 abnormal hematopoietic stem cell physiology 0.00415439440541789 0.0282351259111393 1.29009895052474 0.608695652173913 19.3 19 3 abnormal angiogenesis 3.38936738880539e-07 8.92174749169674e-06 1.28885368126747 0.608108108108108 19.3 19 3 abnormal trophoblast layer morphology 2.27076274188252e-05 0.000371613310554788 1.28829208924949 0.607843137254902 19.3 19 3 short mandible 9.54555276110524e-06 0.000175885648098143 1.2868078817734 0.607142857142857 19.3 19 3 shortened head 0.001673919578482 0.0138795831715799 1.2868078817734 0.607142857142857 19.3 19 3 absent corpus callosum 0.001673919578482 0.0138795831715799 1.2868078817734 0.607142857142857 19.3 19 3 hypoxia 0.001673919578482 0.0138795831715799 1.2868078817734 0.607142857142857 19.3 19 3 abnormal long bone morphology 4.02528691066674e-06 8.24107093850494e-05 1.2855669869983 0.60655737704918 19.3 19 3 postnatal growth retardation 1.55770660080627e-48 1.2915983898352e-45 1.28482893847194 0.606209150326797 19.3 19 3 decreased circulating serum albumin level 4.77191516400183e-09 1.89922223527273e-07 1.28451410658307 0.606060606060606 19.3 19 3 abnormal locomotor coordination 0.000683197778873305 0.00658703284863312 1.28451410658307 0.606060606060606 19.3 19 3 abnormal embryonic tissue morphology 1.10590294203334e-12 8.33616232820587e-11 1.28320337790289 0.605442176870748 19.3 19 3 abnormal frontal bone morphology 0.000281464414829569 0.00312563719593104 1.28282395644283 0.605263157894737 19.3 19 3 decreased total retina thickness 0.000281464414829569 0.00312563719593104 1.28282395644283 0.605263157894737 19.3 19 3 increased circulating alkaline phosphatase level 8.77590314354664e-14 8.15618673997887e-12 1.28213537675607 0.604938271604938 19.3 19 3 oligodactyly 4.87268556717391e-05 0.000717207417061841 1.2805 0.604166666666667 19.3 19 3 small heart 4.87268556717391e-05 0.000717207417061841 1.2805 0.604166666666667 19.3 19 3 vertebral transformation 4.87268556717391e-05 0.000717207417061841 1.2805 0.604166666666667 19.3 19 3 abnormal mesoderm development 2.04216089735973e-05 0.000345328171008785 1.27966688353936 0.60377358490566 19.3 19 3 increased circulating aspartate transaminase level 3.62430165073105e-06 7.64021216626567e-05 1.2783973727422 0.603174603174603 19.3 19 3 pericardial edema 1.53305758453049e-06 3.48263081417314e-05 1.27790263691684 0.602941176470588 19.3 19 3 astrocytosis 6.49881361584023e-07 1.60592638925351e-05 1.27747567312234 0.602739726027397 19.3 19 3 abnormal suckling behavior 5.00125869767126e-08 1.6587508013943e-06 1.27648589341693 0.602272727272727 19.3 19 3 abnormal heart development 3.51000303580068e-13 3.0107353626049e-11 1.27435181143605 0.60126582278481 19.3 19 3 domed cranium 1.37776074926168e-06 3.18807429189621e-05 1.27166896551724 0.6 19.3 19 3 abnormal liver development 0.000608856105910486 0.00591613110723568 1.27166896551724 0.6 19.3 19 3 abnormal artery morphology 0.000608856105910486 0.00591613110723568 1.27166896551724 0.6 19.3 19 3 decreased circulating thyroxine level 0.000608856105910486 0.00591613110723568 1.27166896551724 0.6 19.3 19 3 abnormal rostral-caudal axis patterning 1.83124832290996e-05 0.000312002068714968 1.27166896551724 0.6 19.3 19 3 abnormal hindlimb morphology 4.36481395418343e-05 0.000666102743008055 1.27166896551724 0.6 19.3 19 3 decreased circulating alkaline phosphatase level 4.36481395418343e-05 0.000666102743008055 1.27166896551724 0.6 19.3 19 3 abnormal cellular respiration 0.00148742937583658 0.0126279200422986 1.27166896551724 0.6 19.3 19 3 abnormal thyroid gland morphology 0.00367631881302756 0.0252969378904732 1.27166896551724 0.6 19.3 19 3 diaphragmatic hernia 0.00367631881302756 0.0252969378904732 1.27166896551724 0.6 19.3 19 3 abnormal pericardium morphology 0.00923837794478136 0.0535347885203806 1.27166896551724 0.6 19.3 19 3 decreased paired-pulse facilitation 0.00923837794478136 0.0535347885203806 1.27166896551724 0.6 19.3 19 3 abnormal hyoid bone morphology 0.00923837794478136 0.0535347885203806 1.27166896551724 0.6 19.3 19 3 absent placental labyrinth 0.00923837794478136 0.0535347885203806 1.27166896551724 0.6 19.3 19 3 abnormal optic stalk morphology 0.00923837794478136 0.0535347885203806 1.27166896551724 0.6 19.3 19 3 abnormal induced retinal neovascularization 0.00923837794478136 0.0535347885203806 1.27166896551724 0.6 19.3 19 3 abnormal neuron proliferation 0.00923837794478136 0.0535347885203806 1.27166896551724 0.6 19.3 19 3 abnormal fontanelle morphology 0.0238164035360328 0.110631753120227 1.27166896551724 0.6 19.3 19 3 decreased chondrocyte number 0.0238164035360328 0.110631753120227 1.27166896551724 0.6 19.3 19 3 arthritis 0.0238164035360328 0.110631753120227 1.27166896551724 0.6 19.3 19 3 abnormal glial cell morphology 0.0238164035360328 0.110631753120227 1.27166896551724 0.6 19.3 19 3 abnormal zygomatic bone morphology 0.0238164035360328 0.110631753120227 1.27166896551724 0.6 19.3 19 3 immune system phenotype 0.0238164035360328 0.110631753120227 1.27166896551724 0.6 19.3 19 3 absent chorion 0.0238164035360328 0.110631753120227 1.27166896551724 0.6 19.3 19 3 bicuspid aortic valve 0.0238164035360328 0.110631753120227 1.27166896551724 0.6 19.3 19 3 retarded hair growth 0.0642028149028587 0.221044293523683 1.27166896551724 0.6 19.3 19 3 increased cranium width 0.0642028149028587 0.221044293523683 1.27166896551724 0.6 19.3 19 3 abnormal grooming behavior 0.0642028149028587 0.221044293523683 1.27166896551724 0.6 19.3 19 3 abnormal pituitary secretion 0.0642028149028587 0.221044293523683 1.27166896551724 0.6 19.3 19 3 decreased incidence of induced tumors 0.0642028149028587 0.221044293523683 1.27166896551724 0.6 19.3 19 3 abnormal respiratory mechanics 0.0642028149028587 0.221044293523683 1.27166896551724 0.6 19.3 19 3 abnormal PNS synaptic transmission 0.0642028149028587 0.221044293523683 1.27166896551724 0.6 19.3 19 3 abnormal neuron specification 0.0642028149028587 0.221044293523683 1.27166896551724 0.6 19.3 19 3 abnormal tibialis anterior morphology 0.0642028149028587 0.221044293523683 1.27166896551724 0.6 19.3 19 3 aneurysm 0.0642028149028587 0.221044293523683 1.27166896551724 0.6 19.3 19 3 absent seminal vesicle 0.0642028149028587 0.221044293523683 1.27166896551724 0.6 19.3 19 3 abnormal glial cell physiology 0.0642028149028587 0.221044293523683 1.27166896551724 0.6 19.3 19 3 abnormal pillar cell morphology 0.0642028149028587 0.221044293523683 1.27166896551724 0.6 19.3 19 3 abnormal hindlimb zeugopod morphology 0.0642028149028587 0.221044293523683 1.27166896551724 0.6 19.3 19 3 abnormal gas homeostasis 0.0642028149028587 0.221044293523683 1.27166896551724 0.6 19.3 19 3 abnormal cochlear inner hair cell physiology 0.0642028149028587 0.221044293523683 1.27166896551724 0.6 19.3 19 3 increased susceptibility to atherosclerosis 0.0642028149028587 0.221044293523683 1.27166896551724 0.6 19.3 19 3 tachypnea 0.0642028149028587 0.221044293523683 1.27166896551724 0.6 19.3 19 3 decreased thyroxine level 0.0642028149028587 0.221044293523683 1.27166896551724 0.6 19.3 19 3 vascular smooth muscle hyperplasia 0.0642028149028587 0.221044293523683 1.27166896551724 0.6 19.3 19 3 decreased transitional stage T2 B cell number 0.0642028149028587 0.221044293523683 1.27166896551724 0.6 19.3 19 3 abnormal cerebellar granule cell migration 0.0642028149028587 0.221044293523683 1.27166896551724 0.6 19.3 19 3 abnormal retinal blood vessel pattern 0.0642028149028587 0.221044293523683 1.27166896551724 0.6 19.3 19 3 abnormal heart and great artery attachment 0.0642028149028587 0.221044293523683 1.27166896551724 0.6 19.3 19 3 abnormal left subclavian artery morphology 0.0642028149028587 0.221044293523683 1.27166896551724 0.6 19.3 19 3 thin ventricle myocardium compact layer 0.0642028149028587 0.221044293523683 1.27166896551724 0.6 19.3 19 3 increased fatty acid oxidation 0.0642028149028587 0.221044293523683 1.27166896551724 0.6 19.3 19 3 decreased erythrocyte cell number 6.64032404134225e-13 5.24374795328217e-11 1.26896903140786 0.598726114649682 19.3 19 3 abnormal brain morphology 5.37557294057959e-13 4.38417629170221e-11 1.26377040051403 0.596273291925466 19.3 19 3 neonatal lethality, incomplete penetrance 4.73056345742389e-20 1.0697524182129e-17 1.26351724137931 0.596153846153846 19.3 19 3 distended pericardium 3.89898645042349e-05 0.000600540482689067 1.26351724137931 0.596153846153846 19.3 19 3 eyelids open at birth 3.89898645042349e-05 0.000600540482689067 1.26351724137931 0.596153846153846 19.3 19 3 abnormal motor coordination/ balance 1.5500741148565e-08 5.71231016400822e-07 1.26310553814002 0.595959595959596 19.3 19 3 increased cellular sensitivity to gamma-irradiation 9.31810574448243e-05 0.00122964392781963 1.26265003668379 0.595744680851064 19.3 19 3 spina bifida 0.000223769714118853 0.00255920535112941 1.2615763546798 0.595238095238095 19.3 19 3 abnormal myocardium layer morphology 4.69712064881444e-07 1.19836796040266e-05 1.26093758184199 0.594936708860759 19.3 19 3 lethality throughout fetal growth and development, complete penetrance 6.37659248993916e-15 7.37756921801101e-13 1.26051397459165 0.594736842105263 19.3 19 3 abnormal calcium ion homeostasis 0.000540637731470252 0.00541181632608552 1.26021248835042 0.594594594594595 19.3 19 3 abnormal hepatocyte morphology 2.54198381168282e-09 1.07172622568831e-07 1.26021248835042 0.594594594594595 19.3 19 3 decreased spleen weight 2.6087412311418e-06 5.61839291122531e-05 1.25938230884558 0.594202898550725 19.3 19 3 abnormal tooth morphology 6.16696069658503e-06 0.000120789879785474 1.2584224137931 0.59375 19.3 19 3 polydipsia 0.00131643018882467 0.0112917934300048 1.2584224137931 0.59375 19.3 19 3 failure of primitive streak formation 0.00131643018882467 0.0112917934300048 1.2584224137931 0.59375 19.3 19 3 abnormal embryonic hematopoiesis 0.00131643018882467 0.0112917934300048 1.2584224137931 0.59375 19.3 19 3 bradykinesia 0.00131643018882467 0.0112917934300048 1.2584224137931 0.59375 19.3 19 3 small spleen 7.62193695200996e-08 2.4307138677083e-06 1.25769458128079 0.593406593406593 19.3 19 3 increased oxygen consumption 1.78808205069004e-07 5.11247597826607e-06 1.25688211708099 0.593023255813954 19.3 19 3 abnormal heart valve morphology 0.0032388874559978 0.022986398136361 1.255969348659 0.592592592592593 19.3 19 3 abnormal trigeminal nerve morphology 0.0032388874559978 0.022986398136361 1.255969348659 0.592592592592593 19.3 19 3 increased brain weight 0.0032388874559978 0.022986398136361 1.255969348659 0.592592592592593 19.3 19 3 abnormal skin appearance 0.0032388874559978 0.022986398136361 1.255969348659 0.592592592592593 19.3 19 3 abnormal craniofacial development 8.28887208246008e-05 0.00113600932810575 1.25436734693878 0.591836734693878 19.3 19 3 embryonic lethality during organogenesis, incomplete penetrance 2.34865366684615e-17 3.89485066418652e-15 1.25323898050975 0.591304347826087 19.3 19 3 decreased leukocyte cell number 6.17486803839831e-11 3.70120102301586e-09 1.25310445507173 0.591240875912409 19.3 19 3 abnormal astrocyte morphology 0.000198629817030713 0.00233613082677966 1.2524012539185 0.590909090909091 19.3 19 3 muscular atrophy 0.000198629817030713 0.00233613082677966 1.2524012539185 0.590909090909091 19.3 19 3 aphakia 0.00808480379393707 0.0477694760983812 1.2524012539185 0.590909090909091 19.3 19 3 abnormal lysosome physiology 0.00808480379393707 0.0477694760983812 1.2524012539185 0.590909090909091 19.3 19 3 abnormal cochlear sensory epithelium morphology 0.00808480379393707 0.0477694760983812 1.2524012539185 0.590909090909091 19.3 19 3 cleft upper lip 0.00808480379393707 0.0477694760983812 1.2524012539185 0.590909090909091 19.3 19 3 abnormal temporal bone morphology 0.00808480379393707 0.0477694760983812 1.2524012539185 0.590909090909091 19.3 19 3 abnormal cerebral cortex pyramidal cell morphology 0.00808480379393707 0.0477694760983812 1.2524012539185 0.590909090909091 19.3 19 3 increased bone volume 0.00808480379393707 0.0477694760983812 1.2524012539185 0.590909090909091 19.3 19 3 embryonic lethality before implantation, incomplete penetrance 0.00808480379393707 0.0477694760983812 1.2524012539185 0.590909090909091 19.3 19 3 abnormal erythropoiesis 1.11206489119593e-08 4.19130517704525e-07 1.25148374384236 0.59047619047619 19.3 19 3 pale yolk sac 3.75007439028945e-07 9.76786392235079e-06 1.2512405484005 0.590361445783133 19.3 19 3 abnormal cornea morphology 8.81436261513867e-07 2.10824298126514e-05 1.24993103448276 0.58974358974359 19.3 19 3 ataxia 3.30182158465633e-15 3.91108628182506e-13 1.2485858654831 0.589108910891089 19.3 19 3 decreased body size 4.77133211179911e-56 5.93434431405014e-53 1.24829660357791 0.588972431077694 19.3 19 3 perinatal lethality, incomplete penetrance 9.0791355702593e-17 1.45705482135613e-14 1.24728593225511 0.588495575221239 19.3 19 3 abnormal brown adipose tissue morphology 0.00116131511385954 0.0103827188794568 1.24673427991886 0.588235294117647 19.3 19 3 abnormal adipose tissue morphology 0.0206190148426935 0.0975091243749052 1.24673427991886 0.588235294117647 19.3 19 3 abnormal dorsal-ventral axis patterning 0.0206190148426935 0.0975091243749052 1.24673427991886 0.588235294117647 19.3 19 3 abnormal involuntary movement 0.0206190148426935 0.0975091243749052 1.24673427991886 0.588235294117647 19.3 19 3 decreased growth hormone level 0.0206190148426935 0.0975091243749052 1.24673427991886 0.588235294117647 19.3 19 3 pancytopenia 0.0206190148426935 0.0975091243749052 1.24673427991886 0.588235294117647 19.3 19 3 coloboma 0.0206190148426935 0.0975091243749052 1.24673427991886 0.588235294117647 19.3 19 3 abnormal allantois morphology 0.000175885389289639 0.00212385876630086 1.244023988006 0.58695652173913 19.3 19 3 abnormal bone mineralization 1.4518690372743e-09 6.56640769130878e-08 1.24364320319179 0.586776859504132 19.3 19 3 abnormal spinal nerve morphology 0.00284375184259978 0.0204729782865393 1.24243519619501 0.586206896551724 19.3 19 3 decreased trophoblast giant cell number 0.00284375184259978 0.0204729782865393 1.24243519619501 0.586206896551724 19.3 19 3 abnormal outer ear morphology 0.00284375184259978 0.0204729782865393 1.24243519619501 0.586206896551724 19.3 19 3 short humerus 0.000422613387962963 0.00441702017881458 1.24065264928511 0.585365853658537 19.3 19 3 decreased rib number 2.6468100141038e-07 7.11777287576561e-06 1.23832932971716 0.584269662921348 19.3 19 3 respiratory distress 8.53221306714044e-13 6.53042461677287e-11 1.23736575642814 0.583815028901734 19.3 19 3 cochlear outer hair cell degeneration 3.85894575086046e-06 7.99543571172124e-05 1.23634482758621 0.583333333333333 19.3 19 3 intracranial hemorrhage 2.42837782735404e-05 0.000392246093866439 1.23634482758621 0.583333333333333 19.3 19 3 muscular ventricular septal defect 2.42837782735404e-05 0.000392246093866439 1.23634482758621 0.583333333333333 19.3 19 3 abnormal pharyngeal arch morphology 0.00102175899198964 0.00934421136975817 1.23634482758621 0.583333333333333 19.3 19 3 abnormal malleus morphology 0.00705082358419195 0.0422992028035696 1.23634482758621 0.583333333333333 19.3 19 3 abnormal body weight 0.00705082358419195 0.0422992028035696 1.23634482758621 0.583333333333333 19.3 19 3 hemolytic anemia 0.00705082358419195 0.0422992028035696 1.23634482758621 0.583333333333333 19.3 19 3 apnea 0.00705082358419195 0.0422992028035696 1.23634482758621 0.583333333333333 19.3 19 3 blindness 0.00705082358419195 0.0422992028035696 1.23634482758621 0.583333333333333 19.3 19 3 prolonged QT interval 0.00705082358419195 0.0422992028035696 1.23634482758621 0.583333333333333 19.3 19 3 amyloidosis 0.0544735450378384 0.194968263714566 1.23634482758621 0.583333333333333 19.3 19 3 mesocardia 0.0544735450378384 0.194968263714566 1.23634482758621 0.583333333333333 19.3 19 3 abnormal enteric nervous system morphology 0.0544735450378384 0.194968263714566 1.23634482758621 0.583333333333333 19.3 19 3 impaired embryo implantation 0.0544735450378384 0.194968263714566 1.23634482758621 0.583333333333333 19.3 19 3 myocarditis 0.0544735450378384 0.194968263714566 1.23634482758621 0.583333333333333 19.3 19 3 abnormal respiratory function 0.0544735450378384 0.194968263714566 1.23634482758621 0.583333333333333 19.3 19 3 abnormal corticospinal tract morphology 0.0544735450378384 0.194968263714566 1.23634482758621 0.583333333333333 19.3 19 3 abnormal AMPA-mediated synaptic currents 0.0544735450378384 0.194968263714566 1.23634482758621 0.583333333333333 19.3 19 3 loss of dopaminergic neurons 0.0544735450378384 0.194968263714566 1.23634482758621 0.583333333333333 19.3 19 3 abnormal vascular endothelial cell development 0.0544735450378384 0.194968263714566 1.23634482758621 0.583333333333333 19.3 19 3 absent ovary 0.0544735450378384 0.194968263714566 1.23634482758621 0.583333333333333 19.3 19 3 abnormal defecation 0.0544735450378384 0.194968263714566 1.23634482758621 0.583333333333333 19.3 19 3 increased hepatocyte proliferation 0.0544735450378384 0.194968263714566 1.23634482758621 0.583333333333333 19.3 19 3 pale placenta 0.0544735450378384 0.194968263714566 1.23634482758621 0.583333333333333 19.3 19 3 bowed ulna 0.0544735450378384 0.194968263714566 1.23634482758621 0.583333333333333 19.3 19 3 stria vascularis degeneration 0.0544735450378384 0.194968263714566 1.23634482758621 0.583333333333333 19.3 19 3 abnormal fatty acid level 0.0544735450378384 0.194968263714566 1.23634482758621 0.583333333333333 19.3 19 3 reduced cerebellar foliation 0.0544735450378384 0.194968263714566 1.23634482758621 0.583333333333333 19.3 19 3 increased type II pneumocyte number 0.0544735450378384 0.194968263714566 1.23634482758621 0.583333333333333 19.3 19 3 respiratory failure 2.78157380279883e-11 1.75168729986382e-09 1.23517515414478 0.582781456953642 19.3 19 3 hydroencephaly 6.24863184951809e-09 2.44779082294114e-07 1.23480899550225 0.582608695652174 19.3 19 3 increased grip strength 2.35081017015678e-07 6.42597834974174e-06 1.2344039408867 0.582417582417582 19.3 19 3 abnormal placenta morphology 1.45535483863785e-06 3.33658540194623e-05 1.23410912265386 0.582278481012658 19.3 19 3 abnormal contextual conditioning behavior 5.76028951746007e-05 0.000818784009981824 1.23313354231975 0.581818181818182 19.3 19 3 abnormal joint morphology 5.76028951746007e-05 0.000818784009981824 1.23313354231975 0.581818181818182 19.3 19 3 microphthalmia 2.47442314402979e-11 1.57823783866002e-09 1.23288167680865 0.581699346405229 19.3 19 3 abnormal eyelid morphology 0.00249012211547155 0.0190819039683488 1.23064738598443 0.580645161290323 19.3 19 3 abnormal nose morphology 0.00249012211547155 0.0190819039683488 1.23064738598443 0.580645161290323 19.3 19 3 pale kidney 0.00249012211547155 0.0190819039683488 1.23064738598443 0.580645161290323 19.3 19 3 decreased double-negative T cell number 0.00249012211547155 0.0190819039683488 1.23064738598443 0.580645161290323 19.3 19 3 small cranium 0.00249012211547155 0.0190819039683488 1.23064738598443 0.580645161290323 19.3 19 3 abnormal bone structure 8.85294641123335e-14 8.15618673997887e-12 1.22993889583706 0.580310880829015 19.3 19 3 cleft palate 8.0953436443419e-10 3.94846417947068e-08 1.22960357988944 0.580152671755725 19.3 19 3 abnormal interventricular septum morphology 0.000137078094976993 0.00172213010734985 1.22928 0.58 19.3 19 3 abnormal axon extension 0.000137078094976993 0.00172213010734985 1.22928 0.58 19.3 19 3 decreased respiratory quotient 0.000137078094976993 0.00172213010734985 1.22928 0.58 19.3 19 3 decreased hair follicle number 0.000897001041851195 0.0083725707002058 1.22704900181488 0.578947368421053 19.3 19 3 decreased neuron apoptosis 0.000897001041851195 0.0083725707002058 1.22704900181488 0.578947368421053 19.3 19 3 abnormal triglyceride level 0.0177974228007843 0.0854654231987472 1.22704900181488 0.578947368421053 19.3 19 3 short vibrissae 0.0177974228007843 0.0854654231987472 1.22704900181488 0.578947368421053 19.3 19 3 abnormal stationary movement 0.0177974228007843 0.0854654231987472 1.22704900181488 0.578947368421053 19.3 19 3 stereotypic behavior 0.0177974228007843 0.0854654231987472 1.22704900181488 0.578947368421053 19.3 19 3 unresponsive to tactile stimuli 0.0177974228007843 0.0854654231987472 1.22704900181488 0.578947368421053 19.3 19 3 abnormal cochlear inner hair cell morphology 0.0177974228007843 0.0854654231987472 1.22704900181488 0.578947368421053 19.3 19 3 eyelids fail to open 0.0177974228007843 0.0854654231987472 1.22704900181488 0.578947368421053 19.3 19 3 Leydig cell hypoplasia 0.0177974228007843 0.0854654231987472 1.22704900181488 0.578947368421053 19.3 19 3 decreased susceptibility to weight gain 0.0177974228007843 0.0854654231987472 1.22704900181488 0.578947368421053 19.3 19 3 embryonic lethality between implantation and somite formation, incomplete penetrance 0.0177974228007843 0.0854654231987472 1.22704900181488 0.578947368421053 19.3 19 3 abnormal craniofacial bone morphology 5.08455559893119e-05 0.000741808331515621 1.22704900181488 0.578947368421053 19.3 19 3 increased bone mineral content 2.66928811236948e-08 9.35190729509729e-07 1.22500221448909 0.577981651376147 19.3 19 3 abnormal nasal bone morphology 0.00613351762551711 0.0386745883231275 1.22275862068966 0.576923076923077 19.3 19 3 abnormal ureter morphology 0.00613351762551711 0.0386745883231275 1.22275862068966 0.576923076923077 19.3 19 3 increased susceptibility to otitis media 0.00613351762551711 0.0386745883231275 1.22275862068966 0.576923076923077 19.3 19 3 increased leukemia incidence 0.00613351762551711 0.0386745883231275 1.22275862068966 0.576923076923077 19.3 19 3 decreased bone resorption 0.00613351762551711 0.0386745883231275 1.22275862068966 0.576923076923077 19.3 19 3 abnormal nerve conduction 0.00613351762551711 0.0386745883231275 1.22275862068966 0.576923076923077 19.3 19 3 abnormal spatial learning 1.36513939917384e-11 9.43273404290257e-10 1.22225851491432 0.576687116564417 19.3 19 3 increased hemoglobin content 4.48171137340559e-05 0.00067622264644327 1.22137697253068 0.576271186440678 19.3 19 3 increased mean corpuscular hemoglobin 1.44795715706271e-07 4.28784931927796e-06 1.22028840125392 0.575757575757576 19.3 19 3 abnormal vascular development 1.67335294322714e-05 0.000288059892475953 1.22028840125392 0.575757575757576 19.3 19 3 abnormal tooth development 0.00217581703090154 0.0170736431052605 1.22028840125392 0.575757575757576 19.3 19 3 belly spot 0.00217581703090154 0.0170736431052605 1.22028840125392 0.575757575757576 19.3 19 3 dextrocardia 0.00217581703090154 0.0170736431052605 1.22028840125392 0.575757575757576 19.3 19 3 abnormal QRS complex 0.00217581703090154 0.0170736431052605 1.22028840125392 0.575757575757576 19.3 19 3 reduced fertility 5.00383808248848e-10 2.56640149076085e-08 1.2198263458199 0.575539568345324 19.3 19 3 extramedullary hematopoiesis 5.499505894304e-08 1.80000275158963e-06 1.21968249837345 0.575471698113208 19.3 19 3 abnormal retinal pigment epithelium morphology 2.36220135147382e-06 5.10954422764445e-05 1.21868275862069 0.575 19.3 19 3 abnormal innervation 0.00028753623728014 0.00318595274046481 1.21755539251651 0.574468085106383 19.3 19 3 decreased body weight 3.07444973144307e-78 1.52953874139292e-74 1.21722756392402 0.574313408723748 19.3 19 3 abnormal small intestine morphology 0.000106143240593312 0.00138599113373157 1.21672030651341 0.574074074074074 19.3 19 3 decreased circulating alanine transaminase level 1.47436045061319e-05 0.000256466546916106 1.21556592292089 0.573529411764706 19.3 19 3 abnormal excitatory postsynaptic potential 2.0839097931152e-06 4.56715912808288e-05 1.21480571909167 0.573170731707317 19.3 19 3 cyanosis 4.7211426989185e-13 3.98096354696941e-11 1.21426724137931 0.572916666666667 19.3 19 3 retinal degeneration 2.97981952272499e-07 7.88542666253022e-06 1.21426724137931 0.572916666666667 19.3 19 3 reduced long term potentiation 3.79224101962038e-08 1.27475669409536e-06 1.21111330049261 0.571428571428571 19.3 19 3 organ of Corti degeneration 0.000252121232063864 0.0028377898857867 1.21111330049261 0.571428571428571 19.3 19 3 increased sarcoma incidence 0.000252121232063864 0.0028377898857867 1.21111330049261 0.571428571428571 19.3 19 3 increased carcinoma incidence 0.00189792712445829 0.0155044128804269 1.21111330049261 0.571428571428571 19.3 19 3 increased red blood cell distribution width 0.00189792712445829 0.0155044128804269 1.21111330049261 0.571428571428571 19.3 19 3 increased bone resorption 0.00532551129268552 0.0347695783216673 1.21111330049261 0.571428571428571 19.3 19 3 abnormal mitotic spindle morphology 0.00532551129268552 0.0347695783216673 1.21111330049261 0.571428571428571 19.3 19 3 prolonged QRS complex duration 0.00532551129268552 0.0347695783216673 1.21111330049261 0.571428571428571 19.3 19 3 abnormal interparietal bone morphology 0.0461921993195132 0.17047937063396 1.21111330049261 0.571428571428571 19.3 19 3 megacephaly 0.0461921993195132 0.17047937063396 1.21111330049261 0.571428571428571 19.3 19 3 translucent skin 0.0461921993195132 0.17047937063396 1.21111330049261 0.571428571428571 19.3 19 3 irregularly shaped pupil 0.0461921993195132 0.17047937063396 1.21111330049261 0.571428571428571 19.3 19 3 increased aggression towards males 0.0461921993195132 0.17047937063396 1.21111330049261 0.571428571428571 19.3 19 3 abnormal fluid regulation 0.0461921993195132 0.17047937063396 1.21111330049261 0.571428571428571 19.3 19 3 abnormal ventral body wall morphology 0.0461921993195132 0.17047937063396 1.21111330049261 0.571428571428571 19.3 19 3 abnormal vascular endothelial cell migration 0.0461921993195132 0.17047937063396 1.21111330049261 0.571428571428571 19.3 19 3 abnormal pancreas development 0.0461921993195132 0.17047937063396 1.21111330049261 0.571428571428571 19.3 19 3 split sternum 0.0461921993195132 0.17047937063396 1.21111330049261 0.571428571428571 19.3 19 3 decreased cornea thickness 0.0461921993195132 0.17047937063396 1.21111330049261 0.571428571428571 19.3 19 3 increased pulmonary respiratory rate 0.0461921993195132 0.17047937063396 1.21111330049261 0.571428571428571 19.3 19 3 sternebra fusion 0.0461921993195132 0.17047937063396 1.21111330049261 0.571428571428571 19.3 19 3 increased stomach tumor incidence 0.0461921993195132 0.17047937063396 1.21111330049261 0.571428571428571 19.3 19 3 small ears 0.0153330677431412 0.0778387877776812 1.21111330049261 0.571428571428571 19.3 19 3 decreased cochlear outer hair cell number 0.0153330677431412 0.0778387877776812 1.21111330049261 0.571428571428571 19.3 19 3 abnormal stapes morphology 0.0153330677431412 0.0778387877776812 1.21111330049261 0.571428571428571 19.3 19 3 embryonic lethality at implantation, complete penetrance 0.0153330677431412 0.0778387877776812 1.21111330049261 0.571428571428571 19.3 19 3 abnormal cervical vertebrae morphology 0.000220802331585205 0.00253482313704786 1.20517647058824 0.568627450980392 19.3 19 3 increased kidney weight 0.000220802331585205 0.00253482313704786 1.20517647058824 0.568627450980392 19.3 19 3 decreased birth weight 5.38529626188064e-07 1.35999233009422e-05 1.2047390199637 0.568421052631579 19.3 19 3 decreased circulating cholesterol level 3.99228485992341e-12 2.7974108701576e-10 1.20449519502544 0.568306010928962 19.3 19 3 hyperglycemia 1.42341092541688e-06 3.27845803423563e-05 1.20423197492163 0.568181818181818 19.3 19 3 embryonic lethality, incomplete penetrance 0.000600951451453545 0.00587373962864713 1.20423197492163 0.568181818181818 19.3 19 3 neonatal lethality, complete penetrance 6.13381625549331e-28 2.34736429777532e-25 1.20380943738657 0.567982456140351 19.3 19 3 abnormal skeleton development 3.77176607654315e-06 7.88425892050511e-05 1.20363729246488 0.567901234567901 19.3 19 3 postnatal lethality, complete penetrance 9.34793922924462e-24 2.90662485409325e-21 1.20248490262641 0.567357512953368 19.3 19 3 abnormal eating behavior 7.16683985670377e-05 0.000995950510812884 1.20102068965517 0.566666666666667 19.3 19 3 abnormal placenta development 0.000193170726342477 0.00229910134821489 1.19968770331815 0.566037735849057 19.3 19 3 deafness 4.16690663102863e-07 1.07411194245427e-05 1.19887983281087 0.565656565656566 19.3 19 3 abnormal blood vessel morphology 9.86577491644005e-10 4.54465094530456e-08 1.19858454221165 0.56551724137931 19.3 19 3 thrombocytopenia 9.86577491644005e-10 4.54465094530456e-08 1.19858454221165 0.56551724137931 19.3 19 3 abnormal skeleton morphology 5.29030393943128e-08 1.74299748997819e-06 1.19794902548726 0.565217391304348 19.3 19 3 abnormal forelimb morphology 0.0005245357191101 0.0052881423608963 1.19794902548726 0.565217391304348 19.3 19 3 fragile skeleton 0.013194335999012 0.0710409324622128 1.19794902548726 0.565217391304348 19.3 19 3 abnormal blood vessel physiology 0.013194335999012 0.0710409324622128 1.19794902548726 0.565217391304348 19.3 19 3 abnormal innervation pattern to muscle 0.013194335999012 0.0710409324622128 1.19794902548726 0.565217391304348 19.3 19 3 abnormal circulating insulin level 0.013194335999012 0.0710409324622128 1.19794902548726 0.565217391304348 19.3 19 3 abnormal ulna morphology 0.013194335999012 0.0710409324622128 1.19794902548726 0.565217391304348 19.3 19 3 abnormal palatal shelf fusion at midline 0.013194335999012 0.0710409324622128 1.19794902548726 0.565217391304348 19.3 19 3 postnatal lethality, incomplete penetrance 9.3606496390895e-34 4.23356654131548e-31 1.19778678970374 0.565140845070423 19.3 19 3 reduced female fertility 1.36933009555721e-14 1.54827664213571e-12 1.19675743162901 0.564655172413793 19.3 19 3 impaired glucose tolerance 1.77577808417071e-15 2.28801107819027e-13 1.19646273637375 0.564516129032258 19.3 19 3 increased tumor incidence 1.77268097408933e-08 6.43729039860906e-07 1.19646273637375 0.564516129032258 19.3 19 3 failure of heart looping 0.00143845042206402 0.01223297581157 1.19558620689655 0.564102564102564 19.3 19 3 cleft secondary palate 9.6594776281816e-07 2.28837624762874e-05 1.19500807043287 0.563829787234043 19.3 19 3 abnormal platelet physiology 0.000168841186759145 0.00205878652972242 1.19459811912226 0.563636363636364 19.3 19 3 corneal opacity 2.05461585163016e-05 0.000345328171008785 1.19405536668286 0.563380281690141 19.3 19 3 decreased liver weight 2.05461585163016e-05 0.000345328171008785 1.19405536668286 0.563380281690141 19.3 19 3 decreased bone mineral content 4.89375788220083e-13 4.05774091065819e-11 1.19218965517241 0.5625 19.3 19 3 abnormal heart atrium morphology 0.00399915459258898 0.0273293874974316 1.19218965517241 0.5625 19.3 19 3 failure of tooth eruption 0.0391826004230212 0.147707312606176 1.19218965517241 0.5625 19.3 19 3 delayed hair appearance 0.0391826004230212 0.147707312606176 1.19218965517241 0.5625 19.3 19 3 disorganized yolk sac vascular plexus 0.0391826004230212 0.147707312606176 1.19218965517241 0.5625 19.3 19 3 decreased cochlear coiling 0.0391826004230212 0.147707312606176 1.19218965517241 0.5625 19.3 19 3 abnormal pulmonary elastic fiber morphology 0.0391826004230212 0.147707312606176 1.19218965517241 0.5625 19.3 19 3 increased pancreatic beta cell number 0.0391826004230212 0.147707312606176 1.19218965517241 0.5625 19.3 19 3 blepharitis 0.0391826004230212 0.147707312606176 1.19218965517241 0.5625 19.3 19 3 kidney degeneration 0.0391826004230212 0.147707312606176 1.19218965517241 0.5625 19.3 19 3 decreased liver cholesterol level 0.0391826004230212 0.147707312606176 1.19218965517241 0.5625 19.3 19 3 embryonic lethality between somite formation and embryo turning, incomplete penetrance 0.0391826004230212 0.147707312606176 1.19218965517241 0.5625 19.3 19 3 decreased fibroblast apoptosis 0.0391826004230212 0.147707312606176 1.19218965517241 0.5625 19.3 19 3 decreased adipocyte glucose uptake 0.0391826004230212 0.147707312606176 1.19218965517241 0.5625 19.3 19 3 hemorrhage 1.88420657737864e-14 2.08309504943527e-12 1.19049860601614 0.561702127659575 19.3 19 3 decreased percent body fat/body weight 1.79896430559302e-05 0.000307554894169253 1.19037505904582 0.561643835616438 19.3 19 3 abnormal facial morphology 0.000147456077970042 0.00181582670272515 1.18986569872958 0.56140350877193 19.3 19 3 abnormal circulating amino acid level 0.000147456077970042 0.00181582670272515 1.18986569872958 0.56140350877193 19.3 19 3 decreased anxiety-related response 3.15397850504053e-08 1.07472897688881e-06 1.18895878889823 0.560975609756098 19.3 19 3 liver fibrosis 0.00125040798199909 0.0109013196852687 1.18895878889823 0.560975609756098 19.3 19 3 increased monocyte cell number 6.5205453392806e-07 1.60592638925351e-05 1.18689103448276 0.56 19.3 19 3 enlarged liver 6.5205453392806e-07 1.60592638925351e-05 1.18689103448276 0.56 19.3 19 3 spontaneous skin ulceration 0.0113456478384011 0.0626466126482194 1.18689103448276 0.56 19.3 19 3 abnormal preimplantation embryo development 0.0113456478384011 0.0626466126482194 1.18689103448276 0.56 19.3 19 3 lethargy 1.7192257944297e-06 3.83549252344743e-05 1.18506785317019 0.559139784946237 19.3 19 3 abnormal endoderm development 0.00346085279248808 0.0239467908798723 1.18439756592292 0.558823529411765 19.3 19 3 abnormal blood circulation 0.00108611134668512 0.00982437081774272 1.18294787489976 0.558139534883721 19.3 19 3 abnormal axon guidance 0.00108611134668512 0.00982437081774272 1.18294787489976 0.558139534883721 19.3 19 3 kidney failure 0.00108611134668512 0.00982437081774272 1.18294787489976 0.558139534883721 19.3 19 3 decreased kidney weight 0.00034700752748349 0.00376927245827202 1.182 0.557692307692308 19.3 19 3 abnormal brain wave pattern 0.00034700752748349 0.00376927245827202 1.182 0.557692307692308 19.3 19 3 abnormal female meiosis 0.00034700752748349 0.00376927245827202 1.182 0.557692307692308 19.3 19 3 premature death 9.56593338274818e-48 6.79864551131031e-45 1.18157395170011 0.557491289198606 19.3 19 3 decreased total body fat amount 3.31943453897451e-19 5.8979238683565e-17 1.18029155482139 0.55688622754491 19.3 19 3 abnormal long bone epiphyseal plate proliferative zone 0.000301955083528934 0.00333087924735354 1.17747126436782 0.555555555555556 19.3 19 3 abnormal brain commissure morphology 0.0097518053374162 0.0561009735906046 1.17747126436782 0.555555555555556 19.3 19 3 abnormal type II pneumocyte morphology 0.0097518053374162 0.0561009735906046 1.17747126436782 0.555555555555556 19.3 19 3 thick interventricular septum 0.0097518053374162 0.0561009735906046 1.17747126436782 0.555555555555556 19.3 19 3 abnormal rib morphology 1.43383270611021e-08 5.32337142753602e-07 1.17747126436782 0.555555555555556 19.3 19 3 decreased susceptibility to hepatic steatosis 9.78320193315068e-05 0.00128760395813293 1.17747126436782 0.555555555555556 19.3 19 3 abnormal megakaryocyte differentiation 0.033260588321508 0.137892855749585 1.17747126436782 0.555555555555556 19.3 19 3 right pulmonary isomerism 0.033260588321508 0.137892855749585 1.17747126436782 0.555555555555556 19.3 19 3 absent spleen 0.033260588321508 0.137892855749585 1.17747126436782 0.555555555555556 19.3 19 3 eye inflammation 0.033260588321508 0.137892855749585 1.17747126436782 0.555555555555556 19.3 19 3 abnormal thyroid cartilage morphology 0.033260588321508 0.137892855749585 1.17747126436782 0.555555555555556 19.3 19 3 abnormal thymus cortex morphology 0.033260588321508 0.137892855749585 1.17747126436782 0.555555555555556 19.3 19 3 abnormal thymus medulla morphology 0.033260588321508 0.137892855749585 1.17747126436782 0.555555555555556 19.3 19 3 abnormal white adipose tissue morphology 0.033260588321508 0.137892855749585 1.17747126436782 0.555555555555556 19.3 19 3 abnormal redox activity 0.033260588321508 0.137892855749585 1.17747126436782 0.555555555555556 19.3 19 3 increased circulating renin level 0.033260588321508 0.137892855749585 1.17747126436782 0.555555555555556 19.3 19 3 abnormal glycogen homeostasis 0.033260588321508 0.137892855749585 1.17747126436782 0.555555555555556 19.3 19 3 increased effector memory CD8-positive, alpha-beta T cell number 0.033260588321508 0.137892855749585 1.17747126436782 0.555555555555556 19.3 19 3 renal tubular acidosis 0.125961077469849 0.324410746351419 1.17747126436782 0.555555555555556 19.3 19 3 abnormal cholinergic neuron morphology 0.125961077469849 0.324410746351419 1.17747126436782 0.555555555555556 19.3 19 3 abnormal geniculate ganglion morphology 0.125961077469849 0.324410746351419 1.17747126436782 0.555555555555556 19.3 19 3 abnormal lung volume 0.125961077469849 0.324410746351419 1.17747126436782 0.555555555555556 19.3 19 3 increased pheochromocytoma incidence 0.125961077469849 0.324410746351419 1.17747126436782 0.555555555555556 19.3 19 3 abnormal thymus lobule morphology 0.125961077469849 0.324410746351419 1.17747126436782 0.555555555555556 19.3 19 3 decreased circulating bicarbonate level 0.125961077469849 0.324410746351419 1.17747126436782 0.555555555555556 19.3 19 3 abnormal artery development 0.125961077469849 0.324410746351419 1.17747126436782 0.555555555555556 19.3 19 3 premature bone ossification 0.125961077469849 0.324410746351419 1.17747126436782 0.555555555555556 19.3 19 3 premature neuronal precursor differentiation 0.125961077469849 0.324410746351419 1.17747126436782 0.555555555555556 19.3 19 3 decreased cellular sensitivity to ionizing radiation 0.125961077469849 0.324410746351419 1.17747126436782 0.555555555555556 19.3 19 3 abnormal bony labyrinth 0.125961077469849 0.324410746351419 1.17747126436782 0.555555555555556 19.3 19 3 abnormal proprioceptive neuron morphology 0.125961077469849 0.324410746351419 1.17747126436782 0.555555555555556 19.3 19 3 abnormal stria vascularis vasculature morphology 0.125961077469849 0.324410746351419 1.17747126436782 0.555555555555556 19.3 19 3 abnormal hair cell mechanoelectric transduction 0.125961077469849 0.324410746351419 1.17747126436782 0.555555555555556 19.3 19 3 abnormal CNS synapse formation 0.125961077469849 0.324410746351419 1.17747126436782 0.555555555555556 19.3 19 3 decreased thyroid-stimulating hormone level 0.125961077469849 0.324410746351419 1.17747126436782 0.555555555555556 19.3 19 3 decreased susceptibility to atherosclerosis 0.125961077469849 0.324410746351419 1.17747126436782 0.555555555555556 19.3 19 3 decreased pulmonary ventilation 0.125961077469849 0.324410746351419 1.17747126436782 0.555555555555556 19.3 19 3 increased tidal volume 0.125961077469849 0.324410746351419 1.17747126436782 0.555555555555556 19.3 19 3 abnormal liver vasculature morphology 0.125961077469849 0.324410746351419 1.17747126436782 0.555555555555556 19.3 19 3 abnormal hyoid bone lesser horn morphology 0.125961077469849 0.324410746351419 1.17747126436782 0.555555555555556 19.3 19 3 retropulsion 0.125961077469849 0.324410746351419 1.17747126436782 0.555555555555556 19.3 19 3 prolonged RR interval 0.125961077469849 0.324410746351419 1.17747126436782 0.555555555555556 19.3 19 3 iris coloboma 0.125961077469849 0.324410746351419 1.17747126436782 0.555555555555556 19.3 19 3 fusion of atlas and occipital bones 0.125961077469849 0.324410746351419 1.17747126436782 0.555555555555556 19.3 19 3 reduced AMPA-mediated synaptic currents 0.125961077469849 0.324410746351419 1.17747126436782 0.555555555555556 19.3 19 3 increased myeloid cell number 0.125961077469849 0.324410746351419 1.17747126436782 0.555555555555556 19.3 19 3 decreased fatty acid oxidation 0.125961077469849 0.324410746351419 1.17747126436782 0.555555555555556 19.3 19 3 adipose tissue inflammation 0.125961077469849 0.324410746351419 1.17747126436782 0.555555555555556 19.3 19 3 impaired coordination 1.50855091826447e-19 3.26306122537641e-17 1.1761100259119 0.554913294797688 19.3 19 3 anemia 1.81199393343027e-12 1.34547310728591e-10 1.1752390913548 0.554502369668246 19.3 19 3 short tail 9.17874657430232e-06 0.000171393369718044 1.17463398421271 0.55421686746988 19.3 19 3 increased granulocyte number 2.78853538374216e-05 0.000446746207941162 1.17428890959925 0.554054054054054 19.3 19 3 abnormal coat/hair pigmentation 2.93504586639113e-07 7.83767200729652e-06 1.17326600985222 0.553571428571429 19.3 19 3 insulin resistance 2.87023241269485e-08 9.84786638148751e-07 1.17211912225705 0.553030303030303 19.3 19 3 seizures 2.56610113207705e-07 6.93823539787138e-06 1.17127404718693 0.552631578947368 19.3 19 3 incomplete somite formation 0.00258739662853738 0.0193859913056829 1.17127404718693 0.552631578947368 19.3 19 3 impaired branching involved in ureteric bud morphogenesis 0.00258739662853738 0.0193859913056829 1.17127404718693 0.552631578947368 19.3 19 3 short limbs 6.99053200794589e-06 0.000135322555406735 1.16935077288942 0.551724137931034 19.3 19 3 aphagia 0.00837998446202184 0.0492212782745675 1.16935077288942 0.551724137931034 19.3 19 3 abnormal embryonic erythropoiesis 0.00837998446202184 0.0492212782745675 1.16935077288942 0.551724137931034 19.3 19 3 abnormal muscle physiology 6.09729684792755e-06 0.000119897438017548 1.16688725300271 0.550561797752809 19.3 19 3 increased or absent threshold for auditory brainstem response 5.44163018837521e-16 7.96238534916667e-14 1.16606323827706 0.550173010380623 19.3 19 3 abnormal cell proliferation 0.028258477624788 0.1264261926109 1.16569655172414 0.55 19.3 19 3 abnormal hearing physiology 0.028258477624788 0.1264261926109 1.16569655172414 0.55 19.3 19 3 abnormal incus morphology 0.028258477624788 0.1264261926109 1.16569655172414 0.55 19.3 19 3 decreased circulating VLDL cholesterol level 0.028258477624788 0.1264261926109 1.16569655172414 0.55 19.3 19 3 abnormal response to tactile stimuli 0.028258477624788 0.1264261926109 1.16569655172414 0.55 19.3 19 3 abnormal heart electrocardiography waveform feature 0.028258477624788 0.1264261926109 1.16569655172414 0.55 19.3 19 3 limb grasping 1.43519751641601e-10 8.20702028065477e-09 1.16453201970443 0.549450549450549 19.3 19 3 atelectasis 5.62218118355347e-05 0.000803745729545359 1.16420398251578 0.549295774647887 19.3 19 3 abnormal response to novel object 0.000614915782370002 0.00596336455612234 1.16361866125761 0.549019607843137 19.3 19 3 osteopetrosis 0.00720053266501482 0.0430560697216932 1.16227808676307 0.548387096774194 19.3 19 3 decreased thymus weight 0.00720053266501482 0.0430560697216932 1.16227808676307 0.548387096774194 19.3 19 3 abnormal cartilage morphology 0.00193153445559269 0.0157273059191058 1.16065024630542 0.547619047619048 19.3 19 3 skin edema 0.00193153445559269 0.0157273059191058 1.16065024630542 0.547619047619048 19.3 19 3 edema 7.36920464859597e-10 3.62988050760049e-08 1.15830312750601 0.546511627906977 19.3 19 3 abnormal myocardial fiber morphology 3.51823052911356e-06 7.44816888610211e-05 1.15804905794525 0.54639175257732 19.3 19 3 osteoporosis 0.00166830322096302 0.0138795831715799 1.15606269592477 0.545454545454545 19.3 19 3 abnormal circadian rhythm 0.00166830322096302 0.0138795831715799 1.15606269592477 0.545454545454545 19.3 19 3 cochlear hair cell degeneration 0.00166830322096302 0.0138795831715799 1.15606269592477 0.545454545454545 19.3 19 3 abnormal tail movements 0.0240309844821862 0.11080087840489 1.15606269592477 0.545454545454545 19.3 19 3 increased skin papilloma incidence 0.0240309844821862 0.11080087840489 1.15606269592477 0.545454545454545 19.3 19 3 increased myocardial infarction size 0.0240309844821862 0.11080087840489 1.15606269592477 0.545454545454545 19.3 19 3 abnormal retinal layer morphology 0.0240309844821862 0.11080087840489 1.15606269592477 0.545454545454545 19.3 19 3 abnormal circulating lipid level 0.0240309844821862 0.11080087840489 1.15606269592477 0.545454545454545 19.3 19 3 abnormal basement membrane morphology 0.0240309844821862 0.11080087840489 1.15606269592477 0.545454545454545 19.3 19 3 abnormal sperm midpiece morphology 0.0240309844821862 0.11080087840489 1.15606269592477 0.545454545454545 19.3 19 3 increased mammary gland tumor incidence 0.0240309844821862 0.11080087840489 1.15606269592477 0.545454545454545 19.3 19 3 absent semicircular canals 0.103791911683137 0.277754793796333 1.15606269592477 0.545454545454545 19.3 19 3 enlarged cranium 0.103791911683137 0.277754793796333 1.15606269592477 0.545454545454545 19.3 19 3 abnormal glossopharyngeal ganglion morphology 0.103791911683137 0.277754793796333 1.15606269592477 0.545454545454545 19.3 19 3 failure of somite differentiation 0.103791911683137 0.277754793796333 1.15606269592477 0.545454545454545 19.3 19 3 abnormal hypothalamus secretion 0.103791911683137 0.277754793796333 1.15606269592477 0.545454545454545 19.3 19 3 abnormal fear/anxiety-related behavior 0.103791911683137 0.277754793796333 1.15606269592477 0.545454545454545 19.3 19 3 abnormal larynx morphology 0.103791911683137 0.277754793796333 1.15606269592477 0.545454545454545 19.3 19 3 abnormal bronchiole morphology 0.103791911683137 0.277754793796333 1.15606269592477 0.545454545454545 19.3 19 3 abnormal frequency of paradoxical sleep 0.103791911683137 0.277754793796333 1.15606269592477 0.545454545454545 19.3 19 3 loss of cortex neurons 0.103791911683137 0.277754793796333 1.15606269592477 0.545454545454545 19.3 19 3 impaired luteinization 0.103791911683137 0.277754793796333 1.15606269592477 0.545454545454545 19.3 19 3 pathological neovascularization 0.103791911683137 0.277754793796333 1.15606269592477 0.545454545454545 19.3 19 3 pharyngeal arch hypoplasia 0.103791911683137 0.277754793796333 1.15606269592477 0.545454545454545 19.3 19 3 abnormal crista ampullaris neuroepithelium morphology 0.103791911683137 0.277754793796333 1.15606269592477 0.545454545454545 19.3 19 3 increased motor neuron number 0.103791911683137 0.277754793796333 1.15606269592477 0.545454545454545 19.3 19 3 increased glycogen level 0.103791911683137 0.277754793796333 1.15606269592477 0.545454545454545 19.3 19 3 increased circulating triiodothyronine level 0.103791911683137 0.277754793796333 1.15606269592477 0.545454545454545 19.3 19 3 abnormal palate development 0.103791911683137 0.277754793796333 1.15606269592477 0.545454545454545 19.3 19 3 abnormal aorta smooth muscle morphology 0.103791911683137 0.277754793796333 1.15606269592477 0.545454545454545 19.3 19 3 increased number of Howell-Jolly bodies 0.103791911683137 0.277754793796333 1.15606269592477 0.545454545454545 19.3 19 3 decreased core body temperature 0.103791911683137 0.277754793796333 1.15606269592477 0.545454545454545 19.3 19 3 abnormal brain ependyma motile cilium morphology 0.103791911683137 0.277754793796333 1.15606269592477 0.545454545454545 19.3 19 3 decreased embryonic cilium length 0.103791911683137 0.277754793796333 1.15606269592477 0.545454545454545 19.3 19 3 abnormal phrenic nerve innervation pattern to diaphragm 0.103791911683137 0.277754793796333 1.15606269592477 0.545454545454545 19.3 19 3 abnormal motor capabilities/coordination/movement 7.56506381408873e-08 2.4307138677083e-06 1.15606269592476 0.545454545454545 19.3 19 3 abnormal CNS synaptic transmission 3.06433146172365e-06 6.54293949445286e-05 1.15606269592476 0.545454545454545 19.3 19 3 enlarged pericardium 0.0061871596666139 0.0387375612682697 1.15606269592476 0.545454545454545 19.3 19 3 abnormal epidermis stratum basale morphology 0.0061871596666139 0.0387375612682697 1.15606269592476 0.545454545454545 19.3 19 3 abnormal middle ear ossicle morphology 0.0061871596666139 0.0387375612682697 1.15606269592476 0.545454545454545 19.3 19 3 cardiovascular system phenotype 0.0061871596666139 0.0387375612682697 1.15606269592476 0.545454545454545 19.3 19 3 increased blood urea nitrogen level 1.93245851120828e-08 6.96665296613131e-07 1.1547338882283 0.544827586206897 19.3 19 3 abnormal pulmonary alveolus morphology 2.66838466127586e-06 5.72207486631354e-05 1.15415500170707 0.544554455445545 19.3 19 3 hyperactivity 3.16929423146198e-19 5.83971807463828e-17 1.15398531462032 0.544474393530997 19.3 19 3 oxidative stress 9.23284886119311e-06 0.000171393369718044 1.15392183908046 0.544444444444444 19.3 19 3 hypoactivity 2.10584657056655e-19 4.19063467542743e-17 1.15248513674197 0.543766578249337 19.3 19 3 abnormal spermatogenesis 3.25874508972319e-10 1.7622018284101e-08 1.15187406296852 0.543478260869565 19.3 19 3 decreased heart weight 2.79272503858697e-05 0.000446746207941162 1.15130523627075 0.54320987654321 19.3 19 3 abnormal retina morphology 2.15557805876466e-11 1.39272738212392e-09 1.15055763546798 0.542857142857143 19.3 19 3 increased circulating serum albumin level 0.00531682702327346 0.0347695783216673 1.15055763546798 0.542857142857143 19.3 19 3 decreased bone volume 0.00531682702327346 0.0347695783216673 1.15055763546798 0.542857142857143 19.3 19 3 decreased bone mineralization 0.00531682702327346 0.0347695783216673 1.15055763546798 0.542857142857143 19.3 19 3 curly tail 0.00124407970971864 0.0108966488659335 1.14803448275862 0.541666666666667 19.3 19 3 abnormal osteoclast morphology 0.00124407970971864 0.0108966488659335 1.14803448275862 0.541666666666667 19.3 19 3 abnormal phalanx morphology 0.00124407970971864 0.0108966488659335 1.14803448275862 0.541666666666667 19.3 19 3 curly vibrissae 0.020454850671072 0.09728765018029 1.14803448275862 0.541666666666667 19.3 19 3 abnormal primitive streak formation 0.020454850671072 0.09728765018029 1.14803448275862 0.541666666666667 19.3 19 3 hypopigmentation 0.020454850671072 0.09728765018029 1.14803448275862 0.541666666666667 19.3 19 3 azoospermia 7.39572843015923e-09 2.85222860000327e-07 1.14636824983735 0.540880503144654 19.3 19 3 small seminiferous tubules 7.36363684460263e-05 0.0010176137028305 1.1456477166822 0.540540540540541 19.3 19 3 abnormal branching of the mammary ductal tree 0.00456949804724734 0.0306791535560803 1.1456477166822 0.540540540540541 19.3 19 3 abnormal humerus morphology 0.00456949804724734 0.0306791535560803 1.1456477166822 0.540540540540541 19.3 19 3 increased trabecular bone volume 0.00456949804724734 0.0306791535560803 1.1456477166822 0.540540540540541 19.3 19 3 abnormal liver physiology 4.59069098429119e-06 9.36011788805274e-05 1.14450206896552 0.54 19.3 19 3 abnormal testis morphology 1.00777042593476e-06 2.37614117015423e-05 1.14265907046477 0.539130434782609 19.3 19 3 decreased circulating HDL cholesterol level 2.55741552322955e-07 6.93823539787138e-06 1.1425150862069 0.5390625 19.3 19 3 abnormal locomotor activation 1.38019708383177e-05 0.00024435873637235 1.14124137931034 0.538461538461538 19.3 19 3 abnormal excitatory postsynaptic currents 5.53857419837843e-05 0.000794075119219962 1.14124137931034 0.538461538461538 19.3 19 3 thick skin 0.0174264664200992 0.0844996787914166 1.14124137931034 0.538461538461538 19.3 19 3 absent trabeculae carneae 0.0860872114136202 0.275497554012314 1.14124137931034 0.538461538461538 19.3 19 3 abnormal pulmonary alveolus epithelial cell morphology 0.0860872114136202 0.275497554012314 1.14124137931034 0.538461538461538 19.3 19 3 abnormal bile duct development 0.0860872114136202 0.275497554012314 1.14124137931034 0.538461538461538 19.3 19 3 absent lateral semicircular canal 0.0860872114136202 0.275497554012314 1.14124137931034 0.538461538461538 19.3 19 3 abnormal retinal inner plexiform layer morphology 0.0860872114136202 0.275497554012314 1.14124137931034 0.538461538461538 19.3 19 3 increased circulating thyroid-stimulating hormone level 0.0860872114136202 0.275497554012314 1.14124137931034 0.538461538461538 19.3 19 3 decreased luteinizing hormone level 0.0860872114136202 0.275497554012314 1.14124137931034 0.538461538461538 19.3 19 3 hyperalgesia 0.0860872114136202 0.275497554012314 1.14124137931034 0.538461538461538 19.3 19 3 orthokeratosis 0.0860872114136202 0.275497554012314 1.14124137931034 0.538461538461538 19.3 19 3 hypoglycemia 1.19822294031402e-05 0.000213661617493271 1.13948832035595 0.537634408602151 19.3 19 3 abnormal posture 4.80255833135796e-05 0.000713215752194205 1.13920344827586 0.5375 19.3 19 3 internal hemorrhage 0.000194577947422368 0.00230482211530067 1.13880802882141 0.537313432835821 19.3 19 3 decreased white adipose tissue amount 0.000194577947422368 0.00230482211530067 1.13880802882141 0.537313432835821 19.3 19 3 diluted coat color 0.000800782413448834 0.00753268433617839 1.13822222222222 0.537037037037037 19.3 19 3 neurodegeneration 0.000800782413448834 0.00753268433617839 1.13822222222222 0.537037037037037 19.3 19 3 decreased platelet aggregation 0.000800782413448834 0.00753268433617839 1.13822222222222 0.537037037037037 19.3 19 3 short ulna 0.00337688069044575 0.0234427370071398 1.13726492851135 0.536585365853659 19.3 19 3 hemopericardium 0.00337688069044575 0.0234427370071398 1.13726492851135 0.536585365853659 19.3 19 3 increased bone trabecula number 0.00337688069044575 0.0234427370071398 1.13726492851135 0.536585365853659 19.3 19 3 enhanced long term potentiation 0.000691397785027614 0.00665319918861195 1.13541871921182 0.535714285714286 19.3 19 3 abnormal circulating cholesterol level 0.0148590676967208 0.075918763318219 1.13541871921182 0.535714285714286 19.3 19 3 straub tail 0.0148590676967208 0.075918763318219 1.13541871921182 0.535714285714286 19.3 19 3 abnormal retinal inner nuclear layer morphology 0.0148590676967208 0.075918763318219 1.13541871921182 0.535714285714286 19.3 19 3 enhanced coordination 0.0148590676967208 0.075918763318219 1.13541871921182 0.535714285714286 19.3 19 3 abnormal hormone level 0.0148590676967208 0.075918763318219 1.13541871921182 0.535714285714286 19.3 19 3 abnormal renal tubule epithelium morphology 0.0148590676967208 0.075918763318219 1.13541871921182 0.535714285714286 19.3 19 3 abnormal skeletal muscle fiber morphology 0.000145771122377989 0.00181302833457623 1.13435259834871 0.535211267605634 19.3 19 3 abnormal organ of Corti morphology 0.00290377103083638 0.0207848678787963 1.13365838011227 0.534883720930233 19.3 19 3 decreased oxygen consumption 0.00290377103083638 0.0207848678787963 1.13365838011227 0.534883720930233 19.3 19 3 decreased grip strength 4.62888617452365e-11 2.84305045904385e-09 1.1323079829948 0.534246575342466 19.3 19 3 increased circulating cholesterol level 3.60366419085173e-09 1.46952699585962e-07 1.13197805642633 0.534090909090909 19.3 19 3 decreased insulin secretion 2.35111967852747e-05 0.000383502308218825 1.1303724137931 0.533333333333333 19.3 19 3 trabecula carnea hypoplasia 0.0024974495829139 0.0190819039683488 1.1303724137931 0.533333333333333 19.3 19 3 abnormal ectoderm development 0.0024974495829139 0.0190819039683488 1.1303724137931 0.533333333333333 19.3 19 3 abnormal response to new environment 0.0126800760767482 0.068718277213314 1.1303724137931 0.533333333333333 19.3 19 3 abnormal microglial cell physiology 0.0126800760767482 0.068718277213314 1.1303724137931 0.533333333333333 19.3 19 3 abnormal fat pad morphology 0.0126800760767482 0.068718277213314 1.1303724137931 0.533333333333333 19.3 19 3 macrocytosis 0.0717645373577765 0.242217485315426 1.1303724137931 0.533333333333333 19.3 19 3 abnormal enteric neuron morphology 0.0717645373577765 0.242217485315426 1.1303724137931 0.533333333333333 19.3 19 3 abnormal prostate gland morphology 0.0717645373577765 0.242217485315426 1.1303724137931 0.533333333333333 19.3 19 3 abnormal pup retrieval 0.0717645373577765 0.242217485315426 1.1303724137931 0.533333333333333 19.3 19 3 no suckling reflex 0.0717645373577765 0.242217485315426 1.1303724137931 0.533333333333333 19.3 19 3 abnormal seizure response to electrical stimulation 0.0717645373577765 0.242217485315426 1.1303724137931 0.533333333333333 19.3 19 3 abnormal apical ectodermal ridge morphology 0.0717645373577765 0.242217485315426 1.1303724137931 0.533333333333333 19.3 19 3 placental labyrinth hypoplasia 0.0717645373577765 0.242217485315426 1.1303724137931 0.533333333333333 19.3 19 3 abnormal lymph node B cell domain morphology 0.0717645373577765 0.242217485315426 1.1303724137931 0.533333333333333 19.3 19 3 increased alcohol consumption 0.0717645373577765 0.242217485315426 1.1303724137931 0.533333333333333 19.3 19 3 decreased aggression towards males 0.0717645373577765 0.242217485315426 1.1303724137931 0.533333333333333 19.3 19 3 abnormal energy homeostasis 0.0717645373577765 0.242217485315426 1.1303724137931 0.533333333333333 19.3 19 3 decreased thymocyte apoptosis 0.0717645373577765 0.242217485315426 1.1303724137931 0.533333333333333 19.3 19 3 abnormal aorta wall morphology 0.0717645373577765 0.242217485315426 1.1303724137931 0.533333333333333 19.3 19 3 decreased brown adipose tissue mass 0.0717645373577765 0.242217485315426 1.1303724137931 0.533333333333333 19.3 19 3 decreased food intake 8.17754022961248e-05 0.00112384703431829 1.12679528590135 0.531645569620253 19.3 19 3 decreased circulating LDL cholesterol level 0.000384331846495275 0.00408161274534921 1.12595689655172 0.53125 19.3 19 3 neonatal lethality 0.0108287611470974 0.0599255691955614 1.12595689655172 0.53125 19.3 19 3 abnormal long term potentiation 0.0108287611470974 0.0599255691955614 1.12595689655172 0.53125 19.3 19 3 increased circulating triglyceride level 1.22608929698548e-07 3.69684500151683e-06 1.12550011890606 0.531034482758621 19.3 19 3 abnormal liver morphology 4.58151733662925e-09 1.8381490927202e-07 1.12484685031786 0.53072625698324 19.3 19 3 decreased circulating creatinine level 0.00184856611981507 0.0152010189191404 1.12460520760028 0.530612244897959 19.3 19 3 decreased circulating glucose level 2.86662775487345e-13 2.50201282113955e-11 1.12429514275121 0.530465949820789 19.3 19 3 abnormal retinal photoreceptor morphology 0.0092542549000055 0.0535347885203806 1.12206085192698 0.529411764705882 19.3 19 3 lung hemorrhage 0.0092542549000055 0.0535347885203806 1.12206085192698 0.529411764705882 19.3 19 3 decreased body fat mass 0.06006663420089 0.21254018858423 1.12206085192698 0.529411764705882 19.3 19 3 abnormal cued conditioning behavior 0.00159088668675169 0.0133243455666492 1.12206085192698 0.529411764705882 19.3 19 3 impaired hematopoiesis 0.00159088668675169 0.0133243455666492 1.12206085192698 0.529411764705882 19.3 19 3 abnormal dendritic spine morphology 0.00159088668675169 0.0133243455666492 1.12206085192698 0.529411764705882 19.3 19 3 cachexia 8.63037029207856e-06 0.000163878214515614 1.12086206896552 0.528846153846154 19.3 19 3 abnormal retinal pigmentation 4.58649851977802e-05 0.000689360427066334 1.12062782401903 0.528735632183908 19.3 19 3 abnormal pancreatic islet morphology 0.00136940697405135 0.0116657529039477 1.11970852309694 0.528301886792453 19.3 19 3 increased circulating bilirubin level 0.00136940697405135 0.0116657529039477 1.11970852309694 0.528301886792453 19.3 19 3 decreased hematocrit 1.78237706308281e-07 5.11247597826607e-06 1.11779121398205 0.527397260273973 19.3 19 3 abnormal learning/memory/conditioning 0.00117899891191378 0.0104368675921193 1.11752727272727 0.527272727272727 19.3 19 3 abnormal definitive hematopoiesis 2.97266014720709e-05 0.000470986758992206 1.11669855394883 0.526881720430108 19.3 19 3 decreased litter size 6.02388633683518e-13 4.833682988025e-11 1.11629304209105 0.526690391459075 19.3 19 3 increased malignant tumor incidence 0.0504418833445343 0.184656636967666 1.11549909255898 0.526315789473684 19.3 19 3 decreased tumor incidence 0.0504418833445343 0.184656636967666 1.11549909255898 0.526315789473684 19.3 19 3 abnormal blastocyst morphology 0.0504418833445343 0.184656636967666 1.11549909255898 0.526315789473684 19.3 19 3 absent amnion 0.0504418833445343 0.184656636967666 1.11549909255898 0.526315789473684 19.3 19 3 right-sided stomach 0.0504418833445343 0.184656636967666 1.11549909255898 0.526315789473684 19.3 19 3 decreased bone mineral density 2.68331134351497e-12 1.96315793146868e-10 1.11549909255898 0.526315789473684 19.3 19 3 abnormal social investigation 0.000119077833803148 0.00150741023707548 1.11271034482759 0.525 19.3 19 3 abnormal pancreatic beta cell morphology 0.00579792511255739 0.0369330056785826 1.11271034482759 0.525 19.3 19 3 decreased hemoglobin content 3.94553671343222e-07 1.02234610152736e-05 1.11233455612619 0.524822695035461 19.3 19 3 abnormal maternal nurturing 0.000753290425826124 0.00716562116345118 1.11184171848502 0.524590163934426 19.3 19 3 increased osteoclast cell number 0.000753290425826124 0.00716562116345118 1.11184171848502 0.524590163934426 19.3 19 3 abnormal gait 8.35670919774578e-14 7.99512081899716e-12 1.11116705724807 0.524271844660194 19.3 19 3 abnormal heart morphology 1.17038841972756e-10 6.77056091644725e-09 1.11018719211823 0.523809523809524 19.3 19 3 arrest of spermatogenesis 8.89006467167222e-05 0.00119240437459677 1.11018719211823 0.523809523809524 19.3 19 3 abnormal optic nerve morphology 0.00496676154878413 0.0330784989360121 1.11018719211823 0.523809523809524 19.3 19 3 disheveled coat 0.00496676154878413 0.0330784989360121 1.11018719211823 0.523809523809524 19.3 19 3 abnormal tumor vascularization 0.0424764284945994 0.158887392301227 1.11018719211823 0.523809523809524 19.3 19 3 vascular ring 0.0424764284945994 0.158887392301227 1.11018719211823 0.523809523809524 19.3 19 3 infertility 1.08127864697044e-05 0.000193502203909279 1.10924395746052 0.523364485981308 19.3 19 3 increased T cell number 6.63892824252596e-05 0.000929375830315379 1.1078934169279 0.522727272727273 19.3 19 3 abnormal myelopoiesis 0.00425690244165005 0.0288529831705845 1.1078934169279 0.522727272727273 19.3 19 3 lethality, incomplete penetrance 0.00425690244165005 0.0288529831705845 1.1078934169279 0.522727272727273 19.3 19 3 decreased compact bone thickness 0.000482086110757242 0.00491470983815016 1.10717447246526 0.522388059701492 19.3 19 3 abnormal carpal bone morphology 0.0358527828274672 0.143960931853631 1.10579910044978 0.521739130434783 19.3 19 3 conjunctivitis 0.0358527828274672 0.143960931853631 1.10579910044978 0.521739130434783 19.3 19 3 abnormal corneal stroma morphology 0.0358527828274672 0.143960931853631 1.10579910044978 0.521739130434783 19.3 19 3 abnormal chondrocyte physiology 0.0358527828274672 0.143960931853631 1.10579910044978 0.521739130434783 19.3 19 3 decreased effector memory CD8-positive, alpha-beta T cell number 0.0358527828274672 0.143960931853631 1.10579910044978 0.521739130434783 19.3 19 3 enlarged heart 1.67627068077841e-10 9.47664390553706e-09 1.10540190249703 0.521551724137931 19.3 19 3 abnormal ovary morphology 0.000358314524663288 0.00386684329761357 1.10450121418164 0.52112676056338 19.3 19 3 increased circulating chloride level 0.00268746685765655 0.0199473630581109 1.10211310344828 0.52 19.3 19 3 decreased oocyte number 0.00268746685765655 0.0199473630581109 1.10211310344828 0.52 19.3 19 3 abnormal egg cylinder morphology 0.0303231537397989 0.13469436594241 1.10211310344828 0.52 19.3 19 3 abnormal keratinocyte physiology 0.0303231537397989 0.13469436594241 1.10211310344828 0.52 19.3 19 3 kinked tail 2.3942611348098e-05 0.000389263043976429 1.10128194726166 0.519607843137255 19.3 19 3 hunched posture 0.000198306765998841 0.00233613082677966 1.09996682671323 0.518987341772152 19.3 19 3 abnormal cochlea morphology 0.00198177188546946 0.0159218839078842 1.09897318007663 0.518518518518518 19.3 19 3 abnormal osteoblast physiology 0.00198177188546946 0.0159218839078842 1.09897318007663 0.518518518518518 19.3 19 3 abnormal palate morphology 0.025691486047604 0.117801975195235 1.09897318007663 0.518518518518518 19.3 19 3 increased anxiety-related response 1.0760629756233e-06 2.51333957921405e-05 1.09784371123791 0.517985611510791 19.3 19 3 increased heart weight 1.0760629756233e-06 2.51333957921405e-05 1.09784371123791 0.517985611510791 19.3 19 3 abnormal middle ear morphology 0.0218009425910412 0.102513884111938 1.09626634958383 0.517241379310345 19.3 19 3 abnormal microglial cell morphology 0.0218009425910412 0.102513884111938 1.09626634958383 0.517241379310345 19.3 19 3 decreased bone strength 0.0218009425910412 0.102513884111938 1.09626634958383 0.517241379310345 19.3 19 3 increased retinal apoptosis 0.0218009425910412 0.102513884111938 1.09626634958383 0.517241379310345 19.3 19 3 abnormal long bone epiphyseal plate morphology 0.0012581938183729 0.0109241086324698 1.09504827586207 0.516666666666667 19.3 19 3 increased lung adenoma incidence 0.0185249223825971 0.0887021066924165 1.09390878754171 0.516129032258065 19.3 19 3 abnormal CD8-positive, alpha beta T cell morphology 0.0185249223825971 0.0887021066924165 1.09390878754171 0.516129032258065 19.3 19 3 abnormal enzyme/coenzyme activity 2.94601942786824e-07 7.83767200729652e-06 1.09347331429826 0.515923566878981 19.3 19 3 abnormal tail morphology 0.000800962816851934 0.00753268433617839 1.09183699059561 0.515151515151515 19.3 19 3 myeloid hyperplasia 0.0157604627201112 0.0779808999660853 1.09183699059561 0.515151515151515 19.3 19 3 small testis 1.69147839291397e-11 1.11130713093406e-09 1.09044077961019 0.514492753623188 19.3 19 3 ovary cysts 0.0134232961812512 0.0718847131342567 1.09000197044335 0.514285714285714 19.3 19 3 increased erythroid progenitor cell number 0.0114440856563345 0.0630501950612003 1.08836533084809 0.513513513513513 19.3 19 3 abnormal pancreatic beta cell physiology 0.0114440856563345 0.0630501950612003 1.08836533084809 0.513513513513513 19.3 19 3 abnormal heart looping 0.00976551620692735 0.0561009735906046 1.08689655172414 0.512820512820513 19.3 19 3 impaired macrophage chemotaxis 0.00976551620692735 0.0561009735906046 1.08689655172414 0.512820512820513 19.3 19 3 abnormal mammary gland development 0.00834002175577456 0.0491024949526372 1.08557106812447 0.51219512195122 19.3 19 3 abnormal cholesterol homeostasis 0.00834002175577456 0.0491024949526372 1.08557106812447 0.51219512195122 19.3 19 3 decreased exploration in new environment 0.00020926725586974 0.00244965787753401 1.08495566502463 0.511904761904762 19.3 19 3 abnormal spleen morphology 1.31057807229144e-07 3.9277866925602e-06 1.08408561236623 0.511494252873563 19.3 19 3 short femur 0.000155619930615065 0.00191162754274061 1.08380877742947 0.511363636363636 19.3 19 3 female infertility 7.86083302166642e-11 4.60089932738711e-09 1.08362768991444 0.511278195488722 19.3 19 3 increased circulating corticosterone level 0.00609633043032877 0.0386745883231275 1.08327356321839 0.511111111111111 19.3 19 3 small placenta 0.00609633043032877 0.0386745883231275 1.08327356321839 0.511111111111111 19.3 19 3 enlarged spleen 1.62592424112507e-11 1.09310447291854e-09 1.08180172413793 0.510416666666667 19.3 19 3 cardiac hypertrophy 7.44060554181913e-05 0.00102540201026455 1.08135116115412 0.510204081632653 19.3 19 3 increased circulating LDL cholesterol level 0.00446771473680863 0.0301585899804924 1.08135116115412 0.510204081632653 19.3 19 3 increased fluid intake 0.00446771473680863 0.0301585899804924 1.08135116115412 0.510204081632653 19.3 19 3 cochlear inner hair cell degeneration 0.00382791023539759 0.0262673840291076 1.08050304259635 0.509803921568627 19.3 19 3 decreased cardiac muscle contractility 4.7864552012946e-05 0.000712952533725768 1.08010344827586 0.509615384615385 19.3 19 3 decreased T cell number 5.0329393882828e-07 1.27749354370954e-05 1.07947055043907 0.509316770186335 19.3 19 3 increased macrophage cell number 0.00241472263265538 0.0187122197779759 1.07831578947368 0.508771929824561 19.3 19 3 syndactyly 0.0020727619804158 0.016472828837969 1.07768556399766 0.508474576271186 19.3 19 3 abnormal hair follicle morphology 0.00152902852441845 0.0129589725877032 1.07654515599343 0.507936507936508 19.3 19 3 abnormal fertility/fecundity 0.000718767695248444 0.00687667169973271 1.07424090694379 0.506849315068493 19.3 19 3 spleen hyperplasia 0.000618576307208216 0.00598719285673322 1.07385379310345 0.506666666666667 19.3 19 3 reduced male fertility 4.32667481258221e-09 1.75001684492655e-07 1.07372930274951 0.506607929515419 19.3 19 3 abnormal placenta labyrinth morphology 0.000458483618356913 0.00475699389747139 1.0731383675251 0.506329113924051 19.3 19 3 increased exploration in new environment 0.000394856483614157 0.00417959788506475 1.07280715197957 0.506172839506173 19.3 19 3 increased startle reflex 0.000217669101718099 0.00253482313704786 1.07163115071678 0.50561797752809 19.3 19 3 abnormal glucose homeostasis 1.64858440011422e-07 4.80045895547041e-06 1.07136945812808 0.505494505494505 19.3 19 3 spleen hypoplasia 6.66908887281589e-05 0.000929375830315379 1.06981674876847 0.504761904761905 19.3 19 3 increased circulating HDL cholesterol level 6.66908887281589e-05 0.000929375830315379 1.06981674876847 0.504761904761905 19.3 19 3 increased spleen weight 3.70357366122197e-05 0.000573996229426146 1.06910222764724 0.504424778761062 19.3 19 3 male infertility 2.26199240382378e-17 3.88048696862873e-15 1.06183094536231 0.500994035785288 19.3 19 3 renal interstitial fibrosis 0.00999907697923729 0.057310377847587 1.05972413793103 0.5 19.3 19 3 decreased blood urea nitrogen level 0.00999907697923729 0.057310377847587 1.05972413793103 0.5 19.3 19 3 increased grooming behavior 0.0161163383557439 0.0782232032388545 1.05972413793103 0.5 19.3 19 3 abnormal compact bone morphology 0.0161163383557439 0.0782232032388545 1.05972413793103 0.5 19.3 19 3 hyporesponsive to tactile stimuli 0.0161163383557439 0.0782232032388545 1.05972413793103 0.5 19.3 19 3 abnormal facial nerve morphology 0.0609218725070126 0.214498454155971 1.05972413793103 0.5 19.3 19 3 intestinal inflammation 0.0609218725070126 0.214498454155971 1.05972413793103 0.5 19.3 19 3 testis hypoplasia 0.0609218725070126 0.214498454155971 1.05972413793103 0.5 19.3 19 3 decreased cardiac output 0.0609218725070126 0.214498454155971 1.05972413793103 0.5 19.3 19 3 abnormal blood-brain barrier function 0.0609218725070126 0.214498454155971 1.05972413793103 0.5 19.3 19 3 failure of palatal shelf elevation 0.0609218725070126 0.214498454155971 1.05972413793103 0.5 19.3 19 3 increased circulating creatine kinase level 0.0609218725070126 0.214498454155971 1.05972413793103 0.5 19.3 19 3 increased susceptibility to pharmacologically induced seizures 0.000192832754905006 0.00229910134821489 1.05972413793103 0.5 19.3 19 3 thin ventricular wall 0.000301108186905398 0.00332891828856523 1.05972413793103 0.5 19.3 19 3 increased circulating creatinine level 0.000405661016189379 0.00428484831325299 1.05972413793103 0.5 19.3 19 3 sparse hair 0.000546980587424124 0.00546010772653781 1.05972413793103 0.5 19.3 19 3 abnormal inhibitory postsynaptic currents 0.00156961630117797 0.0132353238955261 1.05972413793103 0.5 19.3 19 3 decreased mean corpuscular hemoglobin 0.00156961630117797 0.0132353238955261 1.05972413793103 0.5 19.3 19 3 abnormal skin morphology 0.00182694464819367 0.0150730507873358 1.05972413793103 0.5 19.3 19 3 increased erythrocyte cell number 0.00288733014245871 0.0207279472708977 1.05972413793103 0.5 19.3 19 3 cochlear ganglion degeneration 0.00336599907825628 0.0234427370071398 1.05972413793103 0.5 19.3 19 3 abnormal seminal vesicle morphology 0.00392583574196655 0.0269022490582418 1.05972413793103 0.5 19.3 19 3 absent corpus luteum 0.00534844960846826 0.0348735737904713 1.05972413793103 0.5 19.3 19 3 abnormal reproductive system morphology 0.011713281962765 0.0644058600693072 1.05972413793103 0.5 19.3 19 3 head bobbing 0.0137331073012973 0.0733858311750313 1.05972413793103 0.5 19.3 19 3 abnormal uterus morphology 0.0189327003432666 0.0903936508711625 1.05972413793103 0.5 19.3 19 3 abnormal spleen red pulp morphology 0.022266670540217 0.104309497116365 1.05972413793103 0.5 19.3 19 3 abnormal lymphatic vessel morphology 0.0262210836180969 0.119569102658141 1.05972413793103 0.5 19.3 19 3 abnormal depression-related behavior 0.0262210836180969 0.119569102658141 1.05972413793103 0.5 19.3 19 3 abnormal heart tube morphology 0.0309218091053342 0.136555355922202 1.05972413793103 0.5 19.3 19 3 abnormal synaptic transmission 0.0309218091053342 0.136555355922202 1.05972413793103 0.5 19.3 19 3 liver hemorrhage 0.0309218091053342 0.136555355922202 1.05972413793103 0.5 19.3 19 3 corneal vascularization 0.0365239043984869 0.14606625754218 1.05972413793103 0.5 19.3 19 3 abnormal digestive system morphology 0.0512507149838623 0.186383265383563 1.05972413793103 0.5 19.3 19 3 increased stereotypic behavior 0.0512507149838623 0.186383265383563 1.05972413793103 0.5 19.3 19 3 abnormal cardiac muscle contractility 0.0512507149838623 0.186383265383563 1.05972413793103 0.5 19.3 19 3 decreased ovulation rate 0.0512507149838623 0.186383265383563 1.05972413793103 0.5 19.3 19 3 abnormal tumor morphology 0.0512507149838623 0.186383265383563 1.05972413793103 0.5 19.3 19 3 abnormal osteoblast morphology 0.0512507149838623 0.186383265383563 1.05972413793103 0.5 19.3 19 3 abnormal retinal ganglion layer morphology 0.0512507149838623 0.186383265383563 1.05972413793103 0.5 19.3 19 3 abnormal lens epithelium morphology 0.0726252890642805 0.244624788825183 1.05972413793103 0.5 19.3 19 3 spleen atrophy 0.0726252890642805 0.244624788825183 1.05972413793103 0.5 19.3 19 3 abnormal heart right ventricle morphology 0.0726252890642805 0.244624788825183 1.05972413793103 0.5 19.3 19 3 abnormal radius morphology 0.0868726800802718 0.275497554012314 1.05972413793103 0.5 19.3 19 3 long tibia 0.0868726800802718 0.275497554012314 1.05972413793103 0.5 19.3 19 3 abnormal neutrophil morphology 0.0868726800802718 0.275497554012314 1.05972413793103 0.5 19.3 19 3 abnormal anterior eye segment morphology 0.0868726800802718 0.275497554012314 1.05972413793103 0.5 19.3 19 3 jerky movement 0.0868726800802718 0.275497554012314 1.05972413793103 0.5 19.3 19 3 decreased lactate dehydrogenase level 0.0868726800802718 0.275497554012314 1.05972413793103 0.5 19.3 19 3 abnormal metanephric mesenchyme morphology 0.0868726800802718 0.275497554012314 1.05972413793103 0.5 19.3 19 3 abnormal tympanic ring morphology 0.104346474292532 0.277754793796333 1.05972413793103 0.5 19.3 19 3 abnormal bone marrow cell number 0.104346474292532 0.277754793796333 1.05972413793103 0.5 19.3 19 3 decreased mast cell number 0.104346474292532 0.277754793796333 1.05972413793103 0.5 19.3 19 3 abnormal mouth morphology 0.104346474292532 0.277754793796333 1.05972413793103 0.5 19.3 19 3 abnormal olfaction 0.104346474292532 0.277754793796333 1.05972413793103 0.5 19.3 19 3 large intestinal inflammation 0.104346474292532 0.277754793796333 1.05972413793103 0.5 19.3 19 3 decreased aggression towards mice 0.104346474292532 0.277754793796333 1.05972413793103 0.5 19.3 19 3 small epididymis 0.104346474292532 0.277754793796333 1.05972413793103 0.5 19.3 19 3 increased thymus weight 0.104346474292532 0.277754793796333 1.05972413793103 0.5 19.3 19 3 decreased circulating triiodothyronine level 0.104346474292532 0.277754793796333 1.05972413793103 0.5 19.3 19 3 decreased creatinine clearance 0.104346474292532 0.277754793796333 1.05972413793103 0.5 19.3 19 3 increased heart left ventricle size 0.104346474292532 0.277754793796333 1.05972413793103 0.5 19.3 19 3 abnormal pulmonary alveolus wall morphology 0.104346474292532 0.277754793796333 1.05972413793103 0.5 19.3 19 3 midline facial cleft 0.125982223507727 0.324410746351419 1.05972413793103 0.5 19.3 19 3 abnormal blood flow velocity 0.125982223507727 0.324410746351419 1.05972413793103 0.5 19.3 19 3 abnormal kidney blood vessel morphology 0.125982223507727 0.324410746351419 1.05972413793103 0.5 19.3 19 3 abnormal pinna reflex 0.125982223507727 0.324410746351419 1.05972413793103 0.5 19.3 19 3 abnormal placing response 0.125982223507727 0.324410746351419 1.05972413793103 0.5 19.3 19 3 abnormal endplate potential 0.125982223507727 0.324410746351419 1.05972413793103 0.5 19.3 19 3 abnormal kidney medulla morphology 0.125982223507727 0.324410746351419 1.05972413793103 0.5 19.3 19 3 intestinal obstruction 0.125982223507727 0.324410746351419 1.05972413793103 0.5 19.3 19 3 abnormal uterus development 0.125982223507727 0.324410746351419 1.05972413793103 0.5 19.3 19 3 abnormal imprinting 0.125982223507727 0.324410746351419 1.05972413793103 0.5 19.3 19 3 abnormal positive T cell selection 0.125982223507727 0.324410746351419 1.05972413793103 0.5 19.3 19 3 premature hair loss 0.125982223507727 0.324410746351419 1.05972413793103 0.5 19.3 19 3 pulmonary alveolar hemorrhage 0.125982223507727 0.324410746351419 1.05972413793103 0.5 19.3 19 3 decreased compact bone area 0.125982223507727 0.324410746351419 1.05972413793103 0.5 19.3 19 3 decreased response to antigen 0.125982223507727 0.324410746351419 1.05972413793103 0.5 19.3 19 3 abnormal adipose tissue distribution 0.153110278328437 0.377987389854981 1.05972413793103 0.5 19.3 19 3 abnormal rectum morphology 0.153110278328437 0.377987389854981 1.05972413793103 0.5 19.3 19 3 absent optic nerve 0.153110278328437 0.377987389854981 1.05972413793103 0.5 19.3 19 3 increased litter size 0.153110278328437 0.377987389854981 1.05972413793103 0.5 19.3 19 3 delayed somite formation 0.153110278328437 0.377987389854981 1.05972413793103 0.5 19.3 19 3 abnormal palatine bone morphology 0.153110278328437 0.377987389854981 1.05972413793103 0.5 19.3 19 3 abnormal patella morphology 0.153110278328437 0.377987389854981 1.05972413793103 0.5 19.3 19 3 abnormal somatic nervous system physiology 0.153110278328437 0.377987389854981 1.05972413793103 0.5 19.3 19 3 impaired behavioral response to cocaine 0.153110278328437 0.377987389854981 1.05972413793103 0.5 19.3 19 3 decreased prostaglandin level 0.153110278328437 0.377987389854981 1.05972413793103 0.5 19.3 19 3 abnormal aorta elastic tissue morphology 0.153110278328437 0.377987389854981 1.05972413793103 0.5 19.3 19 3 increased fibrosarcoma incidence 0.153110278328437 0.377987389854981 1.05972413793103 0.5 19.3 19 3 abnormal respiratory motile cilium morphology 0.153110278328437 0.377987389854981 1.05972413793103 0.5 19.3 19 3 abnormal lateral semicircular canal morphology 0.18771934003684 0.440454285649318 1.05972413793103 0.5 19.3 19 3 jaundice 0.18771934003684 0.440454285649318 1.05972413793103 0.5 19.3 19 3 absent trophoblast giant cells 0.18771934003684 0.440454285649318 1.05972413793103 0.5 19.3 19 3 rhinitis 0.18771934003684 0.440454285649318 1.05972413793103 0.5 19.3 19 3 abnormal mammary gland physiology 0.18771934003684 0.440454285649318 1.05972413793103 0.5 19.3 19 3 delayed dark adaptation 0.18771934003684 0.440454285649318 1.05972413793103 0.5 19.3 19 3 impaired basement membrane formation 0.18771934003684 0.440454285649318 1.05972413793103 0.5 19.3 19 3 abnormal hypaxial muscle morphology 0.18771934003684 0.440454285649318 1.05972413793103 0.5 19.3 19 3 absent CD4-positive, alpha beta T cells 0.18771934003684 0.440454285649318 1.05972413793103 0.5 19.3 19 3 abnormal submandibular gland morphology 0.18771934003684 0.440454285649318 1.05972413793103 0.5 19.3 19 3 increased defecation amount 0.18771934003684 0.440454285649318 1.05972413793103 0.5 19.3 19 3 abnormal reproductive system development 0.18771934003684 0.440454285649318 1.05972413793103 0.5 19.3 19 3 abnormal deltoid tuberosity morphology 0.18771934003684 0.440454285649318 1.05972413793103 0.5 19.3 19 3 absent coat pigmentation 0.18771934003684 0.440454285649318 1.05972413793103 0.5 19.3 19 3 abnormal corneal endothelium morphology 0.18771934003684 0.440454285649318 1.05972413793103 0.5 19.3 19 3 abnormal gonadal fat pad morphology 0.18771934003684 0.440454285649318 1.05972413793103 0.5 19.3 19 3 abnormal sperm principal piece morphology 0.18771934003684 0.440454285649318 1.05972413793103 0.5 19.3 19 3 increased serotonin level 0.18771934003684 0.440454285649318 1.05972413793103 0.5 19.3 19 3 increased kidney iron level 0.18771934003684 0.440454285649318 1.05972413793103 0.5 19.3 19 3 abnormal pulmonary interalveolar septum morphology 0.18771934003684 0.440454285649318 1.05972413793103 0.5 19.3 19 3 abnormal seminiferous tubule morphology 4.92052209917241e-06 9.87589050453849e-05 1.05972413793103 0.5 19.3 19 3 no abnormal phenotype detected 2.89721021688558e-56 4.80454027633526e-53 1.05667017787936 0.498559077809798 19.3 19 3 decreased neutrophil cell number 6.02927153209633e-05 0.000849734443971083 1.05066666666667 0.495726495726496 19.3 19 3 decreased startle reflex 6.02927153209633e-05 0.000849734443971083 1.05066666666667 0.495726495726496 19.3 19 3 decreased B cell number 1.36723997040868e-07 4.07306518130728e-06 1.04943555406763 0.495145631067961 19.3 19 3 alopecia 0.000306072787843047 0.00336883212283 1.04856914700544 0.494736842105263 19.3 19 3 polyuria 0.001175055175963 0.0104204982182102 1.04596148678907 0.493506493506494 19.3 19 3 increased circulating free fatty acid level 0.00184830598246393 0.0152010189191404 1.0447984458475 0.492957746478873 19.3 19 3 abnormal male meiosis 0.00395901028934982 0.0270922643597185 1.04235161107971 0.491803278688525 19.3 19 3 increased sensitivity to xenobiotic induced morbidity/mortality 0.00014729250967323 0.00181582670272515 1.04045642633229 0.490909090909091 19.3 19 3 increased lung adenocarcinoma incidence 0.00857493605880985 0.0503069656752111 1.03894523326572 0.490196078431373 19.3 19 3 abnormal tibia morphology 0.0117289867784507 0.0644058600693072 1.0371768158474 0.48936170212766 19.3 19 3 increased respiratory quotient 0.0117289867784507 0.0644058600693072 1.0371768158474 0.48936170212766 19.3 19 3 abnormal cardiovascular system physiology 3.950094496472e-05 0.00060653457160334 1.03582058594763 0.488721804511278 19.3 19 3 abnormal nervous system electrophysiology 0.00101388268621 0.00928925665542311 1.03449261083744 0.488095238095238 19.3 19 3 increased food intake 0.00101388268621 0.00928925665542311 1.03449261083744 0.488095238095238 19.3 19 3 Leydig cell hyperplasia 0.0188693792494142 0.0901778691314464 1.03387720773759 0.48780487804878 19.3 19 3 thick ventricular wall 0.0188693792494142 0.0901778691314464 1.03387720773759 0.48780487804878 19.3 19 3 abnormal lung morphology 0.000110027310765044 0.00140355351552845 1.03300840336134 0.487394957983193 19.3 19 3 abnormal iris morphology 0.0221496193971196 0.103858959944081 1.03255172413793 0.487179487179487 19.3 19 3 increased vascular permeability 0.0221496193971196 0.103858959944081 1.03255172413793 0.487179487179487 19.3 19 3 decreased trabecular bone volume 0.0221496193971196 0.103858959944081 1.03255172413793 0.487179487179487 19.3 19 3 abnormal long bone metaphysis morphology 0.0260271774150971 0.118902853664011 1.03108294501398 0.486486486486487 19.3 19 3 abnormal vocalization 0.0260271774150971 0.118902853664011 1.03108294501398 0.486486486486487 19.3 19 3 abnormal hair follicle development 0.0260271774150971 0.118902853664011 1.03108294501398 0.486486486486487 19.3 19 3 abnormal respiratory electron transport chain 0.0260271774150971 0.118902853664011 1.03108294501398 0.486486486486487 19.3 19 3 abnormal kidney morphology 3.87316584226094e-06 7.99543571172124e-05 1.02944630541872 0.485714285714286 19.3 19 3 impaired adaptive thermogenesis 0.0306187463236845 0.135644045378745 1.02944630541872 0.485714285714286 19.3 19 3 abnormal T cell differentiation 0.000413928587819363 0.00436291255169774 1.02824718333902 0.485148514851485 19.3 19 3 increased total body fat amount 5.28474660814162e-05 0.000766533648227778 1.02809058157488 0.485074626865672 19.3 19 3 abnormal aorta morphology 0.0360663738750243 0.144352542259249 1.02761128526646 0.484848484848485 19.3 19 3 abnormal ovarian folliculogenesis 0.0360663738750243 0.144352542259249 1.02761128526646 0.484848484848485 19.3 19 3 increased osteoblast cell number 0.0360663738750243 0.144352542259249 1.02761128526646 0.484848484848485 19.3 19 3 head tossing 0.0360663738750243 0.144352542259249 1.02761128526646 0.484848484848485 19.3 19 3 abnormal osteoclast physiology 0.00458967967190833 0.0307731217894123 1.02660775862069 0.484375 19.3 19 3 impaired righting response 0.000645387406921948 0.00623456766880911 1.02625916515427 0.484210526315789 19.3 19 3 absent mature ovarian follicles 0.0425438904079002 0.158900791876354 1.02553948832036 0.483870967741935 19.3 19 3 abnormal mitochondrial ATP synthesis coupled electron transport 0.0425438904079002 0.158900791876354 1.02553948832036 0.483870967741935 19.3 19 3 increased thermal nociceptive threshold 0.000868522360827676 0.0081372857723497 1.0247881773399 0.483516483516484 19.3 19 3 liver inflammation 0.000146905944843312 0.00181582670272515 1.0244 0.483333333333333 19.3 19 3 increased leukocyte cell number 3.39663008282156e-05 0.000533067339496444 1.02318192627824 0.482758620689655 19.3 19 3 abnormal enzyme/coenzyme level 0.00726909443214367 0.0434138593036191 1.02318192627824 0.482758620689655 19.3 19 3 decreased retinal photoreceptor cell number 0.0502653354187697 0.184656636967666 1.02318192627824 0.482758620689655 19.3 19 3 polychromatophilia 0.0502653354187697 0.184656636967666 1.02318192627824 0.482758620689655 19.3 19 3 abnormal blood homeostasis 0.000227996459832978 0.00260156510933272 1.02254083484573 0.482456140350877 19.3 19 3 circling 0.00135779621022949 0.0116065913159652 1.02232210953347 0.482352941176471 19.3 19 3 cardiac fibrosis 0.00135779621022949 0.0116065913159652 1.02232210953347 0.482352941176471 19.3 19 3 abnormal neuron differentiation 0.000264026820807929 0.00294514222762208 1.02187684729064 0.482142857142857 19.3 19 3 abnormal lipid level 0.00157651423819547 0.0132709954907317 1.02142085583714 0.481927710843373 19.3 19 3 abnormal trigeminal ganglion morphology 0.0594961707134006 0.210671494163109 1.02047509578544 0.481481481481481 19.3 19 3 decreased susceptibility to pharmacologically induced seizures 0.0594961707134006 0.210671494163109 1.02047509578544 0.481481481481481 19.3 19 3 decreased bone ossification 0.0594961707134006 0.210671494163109 1.02047509578544 0.481481481481481 19.3 19 3 abnormal visceral yolk sac morphology 0.0021267615659976 0.016794664747362 1.01948144914884 0.481012658227848 19.3 19 3 testicular atrophy 0.0135121685327492 0.0722828370434701 1.01733517241379 0.48 19.3 19 3 abnormal inner ear vestibule morphology 0.0705684638245359 0.240629271780032 1.01733517241379 0.48 19.3 19 3 ruffled hair 0.0705684638245359 0.240629271780032 1.01733517241379 0.48 19.3 19 3 abnormal nest building behavior 0.0705684638245359 0.240629271780032 1.01733517241379 0.48 19.3 19 3 increased liver glycogen level 0.0705684638245359 0.240629271780032 1.01733517241379 0.48 19.3 19 3 seminiferous tubule degeneration 0.00333857970000836 0.0234427370071398 1.01617383089277 0.479452054794521 19.3 19 3 increased lymphocyte cell number 0.00451577849776646 0.0304417317430734 1.01364917541229 0.478260869565217 19.3 19 3 hypotension 0.0839018713799294 0.273712662370589 1.01364917541229 0.478260869565217 19.3 19 3 pancreas inflammation 0.0839018713799294 0.273712662370589 1.01364917541229 0.478260869565217 19.3 19 3 abnormal cochlear ganglion morphology 0.0839018713799294 0.273712662370589 1.01364917541229 0.478260869565217 19.3 19 3 abnormal lens development 0.0839018713799294 0.273712662370589 1.01364917541229 0.478260869565217 19.3 19 3 maternal effect 0.00525437302467137 0.0345773886213493 1.01227380339681 0.477611940298507 19.3 19 3 small kidney 0.00155102740737057 0.0131230635232459 1.01155485893417 0.477272727272727 19.3 19 3 abnormal lipid homeostasis 0.000143229270674987 0.00179036588343734 1.01081379310345 0.476923076923077 19.3 19 3 abnormal spleen white pulp morphology 0.025374922237277 0.116457784253186 1.00926108374384 0.476190476190476 19.3 19 3 abnormal salivary gland morphology 0.100033344127627 0.277754793796333 1.00926108374384 0.476190476190476 19.3 19 3 abnormal hematopoietic system physiology 0.100033344127627 0.277754793796333 1.00926108374384 0.476190476190476 19.3 19 3 increased incidence of induced tumors 0.100033344127627 0.277754793796333 1.00926108374384 0.476190476190476 19.3 19 3 abnormal associative learning 0.100033344127627 0.277754793796333 1.00926108374384 0.476190476190476 19.3 19 3 abnormal erythrocyte physiology 0.100033344127627 0.277754793796333 1.00926108374384 0.476190476190476 19.3 19 3 dry skin 0.100033344127627 0.277754793796333 1.00926108374384 0.476190476190476 19.3 19 3 increased acute inflammation 0.100033344127627 0.277754793796333 1.00926108374384 0.476190476190476 19.3 19 3 increased bone ossification 0.100033344127627 0.277754793796333 1.00926108374384 0.476190476190476 19.3 19 3 decreased vocalization 0.100033344127627 0.277754793796333 1.00926108374384 0.476190476190476 19.3 19 3 increased circulating glucose level 9.10606786319111e-05 0.0012113018080047 1.00711371973588 0.475177304964539 19.3 19 3 increased circulating insulin level 3.25917437923973e-05 0.00051474262021326 1.00673793103448 0.475 19.3 19 3 increased susceptibility to weight loss 0.0297645589123874 0.132568201064572 1.00673793103448 0.475 19.3 19 3 increased urine protein level 0.00326615031312765 0.0231139371377099 1.00537931034483 0.474358974358974 19.3 19 3 abnormal heart ventricle morphology 0.00326615031312765 0.0231139371377099 1.00537931034483 0.474358974358974 19.3 19 3 irregular coat pigmentation 0.119660397142436 0.31581457601253 1.00394918330309 0.473684210526316 19.3 19 3 enlarged adrenal glands 0.119660397142436 0.31581457601253 1.00394918330309 0.473684210526316 19.3 19 3 thin dermal layer 0.119660397142436 0.31581457601253 1.00394918330309 0.473684210526316 19.3 19 3 increased liver adenoma incidence 0.119660397142436 0.31581457601253 1.00394918330309 0.473684210526316 19.3 19 3 osteoarthritis 0.119660397142436 0.31581457601253 1.00394918330309 0.473684210526316 19.3 19 3 oliguria 0.119660397142436 0.31581457601253 1.00394918330309 0.473684210526316 19.3 19 3 increased circulating VLDL cholesterol level 0.119660397142436 0.31581457601253 1.00394918330309 0.473684210526316 19.3 19 3 decreased fertilization frequency 0.119660397142436 0.31581457601253 1.00394918330309 0.473684210526316 19.3 19 3 increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 0.119660397142436 0.31581457601253 1.00394918330309 0.473684210526316 19.3 19 3 small ovary 0.00175697047627794 0.0145198141519647 1.00149753694581 0.472527472527473 19.3 19 3 abnormal B cell differentiation 0.00175697047627794 0.0145198141519647 1.00149753694581 0.472527472527473 19.3 19 3 heart right ventricle hypertrophy 0.0410746822009007 0.153875409600513 1.00085057471264 0.472222222222222 19.3 19 3 impaired wound healing 0.0410746822009007 0.153875409600513 1.00085057471264 0.472222222222222 19.3 19 3 abnormal trabecular bone morphology 0.000446801700820911 0.00465028966858584 0.997387423935091 0.470588235294118 19.3 19 3 abnormal vision 0.0483327768392979 0.177983393616215 0.997387423935091 0.470588235294118 19.3 19 3 abnormal bone remodeling 0.0483327768392979 0.177983393616215 0.997387423935091 0.470588235294118 19.3 19 3 increased susceptibility to weight gain 0.0483327768392979 0.177983393616215 0.997387423935091 0.470588235294118 19.3 19 3 abnormal touch/ nociception 0.143706332151769 0.364969602834542 0.997387423935091 0.470588235294118 19.3 19 3 decreased vasoconstriction 0.143706332151769 0.364969602834542 0.997387423935091 0.470588235294118 19.3 19 3 abnormal testis development 0.143706332151769 0.364969602834542 0.997387423935091 0.470588235294118 19.3 19 3 abnormal melanosome morphology 0.143706332151769 0.364969602834542 0.997387423935091 0.470588235294118 19.3 19 3 abnormal circulating chemokine level 0.143706332151769 0.364969602834542 0.997387423935091 0.470588235294118 19.3 19 3 common atrium 0.143706332151769 0.364969602834542 0.997387423935091 0.470588235294118 19.3 19 3 abnormal electroretinogram waveform feature 0.143706332151769 0.364969602834542 0.997387423935091 0.470588235294118 19.3 19 3 improved glucose tolerance 9.47910988557041e-06 0.000175310675392984 0.994843068261787 0.469387755102041 19.3 19 3 absent kidney 0.0209096095716975 0.0987894659251615 0.994843068261787 0.469387755102041 19.3 19 3 increased sacral vertebrae number 0.00935455432022522 0.0540521576575151 0.993491379310345 0.46875 19.3 19 3 increased dopamine level 0.0569463669871382 0.202942819313046 0.993491379310345 0.46875 19.3 19 3 decreased B cell proliferation 0.00426989754274225 0.0289016874491737 0.992652989960716 0.468354430379747 19.3 19 3 hepatic necrosis 0.024438509972054 0.112367455740267 0.992082171680117 0.468085106382979 19.3 19 3 decreased bone trabecula number 0.024438509972054 0.112367455740267 0.992082171680117 0.468085106382979 19.3 19 3 abnormal renal glomerulus morphology 0.000922389171978461 0.00859341972021132 0.991668459348307 0.467889908256881 19.3 19 3 abnormal cartilage development 0.0285810684985789 0.127411125251281 0.989075862068966 0.466666666666667 19.3 19 3 abnormal ovarian follicle morphology 0.0285810684985789 0.127411125251281 0.989075862068966 0.466666666666667 19.3 19 3 decreased osteoclast cell number 0.0285810684985789 0.127411125251281 0.989075862068966 0.466666666666667 19.3 19 3 epidermal hyperplasia 0.0126682614604215 0.068718277213314 0.989075862068965 0.466666666666667 19.3 19 3 gastrointestinal hemorrhage 0.0671909209430261 0.230693465625642 0.989075862068965 0.466666666666667 19.3 19 3 salivary gland inflammation 0.0671909209430261 0.230693465625642 0.989075862068965 0.466666666666667 19.3 19 3 emphysema 0.0671909209430261 0.230693465625642 0.989075862068965 0.466666666666667 19.3 19 3 enhanced paired-pulse facilitation 0.0671909209430261 0.230693465625642 0.989075862068965 0.466666666666667 19.3 19 3 hyperpigmentation 0.173422698888934 0.420867281449974 0.989075862068965 0.466666666666667 19.3 19 3 abnormal cricoid cartilage morphology 0.173422698888934 0.420867281449974 0.989075862068965 0.466666666666667 19.3 19 3 abnormal bronchus morphology 0.173422698888934 0.420867281449974 0.989075862068965 0.466666666666667 19.3 19 3 abnormal ear development 0.173422698888934 0.420867281449974 0.989075862068965 0.466666666666667 19.3 19 3 abnormal rostral migratory stream morphology 0.173422698888934 0.420867281449974 0.989075862068965 0.466666666666667 19.3 19 3 herniated liver 0.173422698888934 0.420867281449974 0.989075862068965 0.466666666666667 19.3 19 3 glomerulosclerosis 0.0147497950656238 0.075918763318219 0.986639714625446 0.46551724137931 19.3 19 3 thrombocytosis 0.0147497950656238 0.075918763318219 0.986639714625446 0.46551724137931 19.3 19 3 increased triglyceride level 0.0794054681863259 0.260067283888724 0.984029556650246 0.464285714285714 19.3 19 3 hyperkeratosis 0.00899236031390698 0.0525699090031577 0.982932533733133 0.463768115942029 19.3 19 3 abnormal coat appearance 0.00899236031390698 0.0525699090031577 0.982932533733133 0.463768115942029 19.3 19 3 decreased tumor growth/size 0.0200175142289076 0.0954814317246554 0.981226053639847 0.462962962962963 19.3 19 3 abnormal eye electrophysiology 0.000744058167938915 0.007104970029743 0.98090168139071 0.462809917355372 19.3 19 3 abnormal circulating hormone level 0.0459160581439969 0.17047937063396 0.978206896551724 0.461538461538462 19.3 19 3 abnormal skin condition 0.0233337305702942 0.109205371201518 0.978206896551724 0.461538461538462 19.3 19 3 abnormal leukocyte cell number 0.0940101404802823 0.277754793796333 0.978206896551724 0.461538461538462 19.3 19 3 abnormal stomach morphology 0.0940101404802823 0.277754793796333 0.978206896551724 0.461538461538462 19.3 19 3 small seminal vesicle 0.0940101404802823 0.277754793796333 0.978206896551724 0.461538461538462 19.3 19 3 no spontaneous movement 0.0940101404802823 0.277754793796333 0.978206896551724 0.461538461538462 19.3 19 3 abnormal ocular fundus morphology 0.0940101404802823 0.277754793796333 0.978206896551724 0.461538461538462 19.3 19 3 abnormal erythrocyte osmotic lysis 0.0940101404802823 0.277754793796333 0.978206896551724 0.461538461538462 19.3 19 3 absent common myeloid progenitor cells 0.210558621398279 0.479637885282252 0.978206896551724 0.461538461538462 19.3 19 3 abnormal sympathetic ganglion morphology 0.210558621398279 0.479637885282252 0.978206896551724 0.461538461538462 19.3 19 3 uterus hypoplasia 0.210558621398279 0.479637885282252 0.978206896551724 0.461538461538462 19.3 19 3 pup cannibalization 0.210558621398279 0.479637885282252 0.978206896551724 0.461538461538462 19.3 19 3 abnormal tail bud morphology 0.210558621398279 0.479637885282252 0.978206896551724 0.461538461538462 19.3 19 3 increased synaptic depression 0.210558621398279 0.479637885282252 0.978206896551724 0.461538461538462 19.3 19 3 muscle fatigue 0.210558621398279 0.479637885282252 0.978206896551724 0.461538461538462 19.3 19 3 small interparietal bone 0.210558621398279 0.479637885282252 0.978206896551724 0.461538461538462 19.3 19 3 small pituitary gland 0.210558621398279 0.479637885282252 0.978206896551724 0.461538461538462 19.3 19 3 abnormal hair follicle inner root sheath morphology 0.210558621398279 0.479637885282252 0.978206896551724 0.461538461538462 19.3 19 3 decreased cardiac stroke volume 0.210558621398279 0.479637885282252 0.978206896551724 0.461538461538462 19.3 19 3 short stride length 0.0272111334196906 0.123254462136475 0.974946206896552 0.46 19.3 19 3 abnormal intestine morphology 0.00859752480554708 0.0503800776296781 0.97380055917987 0.459459459459459 19.3 19 3 increased circulating phosphate level 0.0538650612688336 0.194968263714566 0.97380055917987 0.459459459459459 19.3 19 3 impaired skeletal muscle contractility 0.0538650612688336 0.194968263714566 0.97380055917987 0.459459459459459 19.3 19 3 decreased circulating chloride level 0.0538650612688336 0.194968263714566 0.97380055917987 0.459459459459459 19.3 19 3 abnormal foregut morphology 0.111529772945832 0.295767921324902 0.971413793103448 0.458333333333333 19.3 19 3 abnormal impulse conducting system conduction 0.111529772945832 0.295767921324902 0.971413793103448 0.458333333333333 19.3 19 3 abnormal inner cell mass apoptosis 0.111529772945832 0.295767921324902 0.971413793103448 0.458333333333333 19.3 19 3 weight loss 0.000107029183556431 0.00139390101621269 0.968890640394089 0.457142857142857 19.3 19 3 abnormal intestinal goblet cell morphology 0.0632498551682352 0.221044293523683 0.968890640394089 0.457142857142857 19.3 19 3 abnormal immune system morphology 0.03705809401443 0.147707312606176 0.967574212893553 0.456521739130435 19.3 19 3 abnormal sleep pattern 0.03705809401443 0.147707312606176 0.967574212893553 0.456521739130435 19.3 19 3 delayed wound healing 0.03705809401443 0.147707312606176 0.967574212893553 0.456521739130435 19.3 19 3 abnormal lymphocyte physiology 0.03705809401443 0.147707312606176 0.967574212893553 0.456521739130435 19.3 19 3 abnormal response to infection 0.0081841945117573 0.0482993685598963 0.965824530772588 0.455696202531646 19.3 19 3 decreased macrophage cell number 0.0432795253004374 0.161527110554896 0.963385579937304 0.454545454545455 19.3 19 3 abnormal oogenesis 0.132626237144806 0.339411280758955 0.963385579937304 0.454545454545455 19.3 19 3 abnormal tracheal cartilage morphology 0.132626237144806 0.339411280758955 0.963385579937304 0.454545454545455 19.3 19 3 abnormal channel response 0.132626237144806 0.339411280758955 0.963385579937304 0.454545454545455 19.3 19 3 abnormal female reproductive system physiology 0.132626237144806 0.339411280758955 0.963385579937304 0.454545454545455 19.3 19 3 abnormal retinal outer plexiform layer morphology 0.132626237144806 0.339411280758955 0.963385579937304 0.454545454545455 19.3 19 3 rough coat 0.132626237144806 0.339411280758955 0.963385579937304 0.454545454545455 19.3 19 3 abnormal thrombopoiesis 0.257658863664925 0.528163513281006 0.963385579937304 0.454545454545455 19.3 19 3 decreased atrioventricular cushion size 0.257658863664925 0.528163513281006 0.963385579937304 0.454545454545455 19.3 19 3 abnormal enteric ganglia morphology 0.257658863664925 0.528163513281006 0.963385579937304 0.454545454545455 19.3 19 3 abnormal hemoglobin 0.257658863664925 0.528163513281006 0.963385579937304 0.454545454545455 19.3 19 3 abnormal primary sex determination 0.257658863664925 0.528163513281006 0.963385579937304 0.454545454545455 19.3 19 3 abnormal vestibular ganglion morphology 0.257658863664925 0.528163513281006 0.963385579937304 0.454545454545455 19.3 19 3 fatigue 0.257658863664925 0.528163513281006 0.963385579937304 0.454545454545455 19.3 19 3 decreased post-tetanic potentiation 0.257658863664925 0.528163513281006 0.963385579937304 0.454545454545455 19.3 19 3 retinal detachment 0.257658863664925 0.528163513281006 0.963385579937304 0.454545454545455 19.3 19 3 abnormal nerve fiber response 0.257658863664925 0.528163513281006 0.963385579937304 0.454545454545455 19.3 19 3 dilated renal glomerular capsule 0.257658863664925 0.528163513281006 0.963385579937304 0.454545454545455 19.3 19 3 abnormal pituitary gland development 0.257658863664925 0.528163513281006 0.963385579937304 0.454545454545455 19.3 19 3 decreased palatine bone horizontal plate size 0.257658863664925 0.528163513281006 0.963385579937304 0.454545454545455 19.3 19 3 shortened PR interval 0.257658863664925 0.528163513281006 0.963385579937304 0.454545454545455 19.3 19 3 abnormal extraembryonic ectoderm morphology 0.257658863664925 0.528163513281006 0.963385579937304 0.454545454545455 19.3 19 3 abnormal pulmonary alveolar sac morphology 0.257658863664925 0.528163513281006 0.963385579937304 0.454545454545455 19.3 19 3 increased subcutaneous adipose tissue amount 0.257658863664925 0.528163513281006 0.963385579937304 0.454545454545455 19.3 19 3 hypolactation 0.257658863664925 0.528163513281006 0.963385579937304 0.454545454545455 19.3 19 3 decreased sensitivity to xenobiotic induced morbidity/mortality 0.0743463612472334 0.247495007536271 0.963385579937304 0.454545454545455 19.3 19 3 abnormal capillary morphology 0.0874884755013649 0.275497554012314 0.957170189098999 0.451612903225806 19.3 19 3 increased body weight 2.94562303441512e-05 0.000468194076556396 0.955644088669951 0.450892857142857 19.3 19 3 abnormal kidney development 0.0242529120288718 0.111720590132998 0.953751724137931 0.45 19.3 19 3 decreased circulating phosphate level 0.0591309211516772 0.210426561323029 0.953751724137931 0.45 19.3 19 3 abnormal skin pigmentation 0.0591309211516772 0.210426561323029 0.953751724137931 0.45 19.3 19 3 waved hair 0.158143667388199 0.386236988343785 0.953751724137931 0.45 19.3 19 3 small gonad 0.158143667388199 0.386236988343785 0.953751724137931 0.45 19.3 19 3 increased urine glucose level 0.158143667388199 0.386236988343785 0.953751724137931 0.45 19.3 19 3 brain inflammation 0.158143667388199 0.386236988343785 0.953751724137931 0.45 19.3 19 3 abnormal trachea morphology 0.158143667388199 0.386236988343785 0.953751724137931 0.45 19.3 19 3 abnormal respiratory system physiology 0.0405782837033443 0.152359970886142 0.951589021815623 0.448979591836735 19.3 19 3 decreased urine osmolality 0.0405782837033443 0.152359970886142 0.951589021815623 0.448979591836735 19.3 19 3 increased T cell proliferation 0.0037206935747012 0.0255669206272631 0.950780534966162 0.448598130841121 19.3 19 3 abnormal spermiogenesis 0.0281414403609825 0.1264261926109 0.950097502972651 0.448275862068966 19.3 19 3 focal hair loss 0.103081826059965 0.277754793796333 0.950097502972651 0.448275862068966 19.3 19 3 increased bone marrow cell number 0.0691797368833776 0.236542399309143 0.948174228675136 0.447368421052632 19.3 19 3 persistence of hyaloid vascular system 0.0691797368833776 0.236542399309143 0.948174228675136 0.447368421052632 19.3 19 3 abnormal reproductive system physiology 0.0691797368833776 0.236542399309143 0.948174228675136 0.447368421052632 19.3 19 3 altered response to myocardial infarction 0.055038290741924 0.196424315954858 0.941977011494253 0.444444444444444 19.3 19 3 abnormal autopod morphology 0.055038290741924 0.196424315954858 0.941977011494253 0.444444444444444 19.3 19 3 albuminuria 0.055038290741924 0.196424315954858 0.941977011494253 0.444444444444444 19.3 19 3 abnormal metabolism 0.055038290741924 0.196424315954858 0.941977011494253 0.444444444444444 19.3 19 3 rectal prolapse 0.121621316293788 0.320649734266876 0.941977011494253 0.444444444444444 19.3 19 3 wrinkled skin 0.121621316293788 0.320649734266876 0.941977011494253 0.444444444444444 19.3 19 3 acidosis 0.189173253808967 0.440454285649318 0.941977011494253 0.444444444444444 19.3 19 3 abnormal body wall morphology 0.189173253808967 0.440454285649318 0.941977011494253 0.444444444444444 19.3 19 3 absent ureter 0.189173253808967 0.440454285649318 0.941977011494253 0.444444444444444 19.3 19 3 abnormal sperm axoneme morphology 0.189173253808967 0.440454285649318 0.941977011494253 0.444444444444444 19.3 19 3 atrioventricular block 0.189173253808967 0.440454285649318 0.941977011494253 0.444444444444444 19.3 19 3 increased liver weight 0.0105797618271144 0.0586781662094696 0.939300940438872 0.443181818181818 19.3 19 3 abnormal action potential 0.0213141626655642 0.100605274441349 0.938612807881773 0.442857142857143 19.3 19 3 increased double-negative T cell number 0.030505493785008 0.135262773244577 0.938116449971735 0.442622950819672 19.3 19 3 abnormal male reproductive system morphology 0.0641303206899567 0.221044293523683 0.93650040096231 0.441860465116279 19.3 19 3 decreased osteoblast cell number 0.0948834015692878 0.277754793796333 0.935050709939148 0.441176470588235 19.3 19 3 increased sensitivity to induced morbidity/mortality 0.000434726474232564 0.00453409687485745 0.933017991004498 0.440217391304348 19.3 19 3 abnormal circulating protein level 0.0510810446405008 0.186383265383563 0.93255724137931 0.44 19.3 19 3 increased pre-B cell number 0.143713658683994 0.364969602834542 0.93255724137931 0.44 19.3 19 3 decreased placenta weight 0.143713658683994 0.364969602834542 0.93255724137931 0.44 19.3 19 3 decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 0.143713658683994 0.364969602834542 0.93255724137931 0.44 19.3 19 3 impaired swimming 0.028431966292901 0.127088079341584 0.931272727272727 0.439393939393939 19.3 19 3 scaly skin 0.0747493559382824 0.247495007536271 0.930489486963835 0.439024390243902 19.3 19 3 increased tumor growth/size 0.0747493559382824 0.247495007536271 0.930489486963835 0.439024390243902 19.3 19 3 absent vitelline blood vessels 0.0408764204878613 0.153363643987262 0.929582577132486 0.43859649122807 19.3 19 3 abnormal lens morphology 0.00360551342647871 0.0248823215424833 0.927258620689655 0.4375 19.3 19 3 abnormal serotonin level 0.111243448790208 0.295481130662725 0.927258620689655 0.4375 19.3 19 3 abnormal pituitary gland morphology 0.227148651352802 0.501849734696051 0.927258620689655 0.4375 19.3 19 3 poor circulation 0.227148651352802 0.501849734696051 0.927258620689655 0.4375 19.3 19 3 abnormal extraembryonic endoderm formation 0.227148651352802 0.501849734696051 0.927258620689655 0.4375 19.3 19 3 impaired muscle relaxation 0.227148651352802 0.501849734696051 0.927258620689655 0.4375 19.3 19 3 abnormal molar crown morphology 0.227148651352802 0.501849734696051 0.927258620689655 0.4375 19.3 19 3 dystonia 0.227148651352802 0.501849734696051 0.927258620689655 0.4375 19.3 19 3 abnormal intestinal lipid absorption 0.227148651352802 0.501849734696051 0.927258620689655 0.4375 19.3 19 3 decreased skeletal muscle weight 0.227148651352802 0.501849734696051 0.927258620689655 0.4375 19.3 19 3 dilated respiratory conducting tubes 0.227148651352802 0.501849734696051 0.927258620689655 0.4375 19.3 19 3 abnormal intestinal epithelium morphology 0.0593090229566109 0.210608414853061 0.927258620689655 0.4375 19.3 19 3 abnormal cardiovascular system morphology 0.0593090229566109 0.210608414853061 0.927258620689655 0.4375 19.3 19 3 abnormal lymph node morphology 0.0593090229566109 0.210608414853061 0.927258620689655 0.4375 19.3 19 3 abnormal epidermal layer morphology 0.0304842735641757 0.135262773244577 0.921499250374813 0.434782608695652 19.3 19 3 abnormal inner ear morphology 0.0688692113015351 0.23596716682172 0.921499250374813 0.434782608695652 19.3 19 3 bidirectional circling 0.170106518502403 0.4140312766876 0.921499250374813 0.434782608695652 19.3 19 3 abnormal cardiovascular development 0.170106518502403 0.4140312766876 0.921499250374813 0.434782608695652 19.3 19 3 increased susceptibility to age related obesity 0.170106518502403 0.4140312766876 0.921499250374813 0.434782608695652 19.3 19 3 lung inflammation 0.00360606107178502 0.0248823215424833 0.919466531440162 0.433823529411765 19.3 19 3 increased metastatic potential 0.13052781232586 0.335248253134307 0.918427586206896 0.433333333333333 19.3 19 3 arrested T cell differentiation 0.13052781232586 0.335248253134307 0.918427586206896 0.433333333333333 19.3 19 3 disorganized myocardium 0.13052781232586 0.335248253134307 0.918427586206896 0.433333333333333 19.3 19 3 increased inflammatory response 0.0149705362379652 0.076309854286759 0.914709255898367 0.431578947368421 19.3 19 3 dermatitis 0.050524132705194 0.184821735447309 0.913555291319857 0.431034482758621 19.3 19 3 abnormal heart left ventricle morphology 0.0325057034479792 0.137892855749585 0.912540229885057 0.430555555555556 19.3 19 3 decreased heart rate 0.0139093600770477 0.0742479253039834 0.91136275862069 0.43 19.3 19 3 cataract 0.00749631874132054 0.0447172490864145 0.910837275577087 0.429752066115702 19.3 19 3 abnormal epidermis stratum corneum morphology 0.0733570773965613 0.246922503415354 0.908334975369458 0.428571428571429 19.3 19 3 abnormal respiration 0.153283202374384 0.377987389854981 0.908334975369458 0.428571428571429 19.3 19 3 absent visceral yolk sac blood islands 0.273990919816193 0.533924775311575 0.908334975369458 0.428571428571429 19.3 19 3 abnormal adrenal gland secretion 0.273990919816193 0.533924775311575 0.908334975369458 0.428571428571429 19.3 19 3 abnormal antigen presentation 0.273990919816193 0.533924775311575 0.908334975369458 0.428571428571429 19.3 19 3 absent otoliths 0.273990919816193 0.533924775311575 0.908334975369458 0.428571428571429 19.3 19 3 decreased coping response 0.273990919816193 0.533924775311575 0.908334975369458 0.428571428571429 19.3 19 3 abnormal prepulse inhibition 0.273990919816193 0.533924775311575 0.908334975369458 0.428571428571429 19.3 19 3 failure of zygotic cell division 0.273990919816193 0.533924775311575 0.908334975369458 0.428571428571429 19.3 19 3 abnormal voluntary movement 0.273990919816193 0.533924775311575 0.908334975369458 0.428571428571429 19.3 19 3 abnormal decidualization 0.273990919816193 0.533924775311575 0.908334975369458 0.428571428571429 19.3 19 3 abnormal squamosal bone morphology 0.273990919816193 0.533924775311575 0.908334975369458 0.428571428571429 19.3 19 3 spina bifida occulta 0.273990919816193 0.533924775311575 0.908334975369458 0.428571428571429 19.3 19 3 abnormal anxiety-related response 0.201726409833628 0.462483358950368 0.908334975369458 0.428571428571429 19.3 19 3 trunk curl 0.201726409833628 0.462483358950368 0.908334975369458 0.428571428571429 19.3 19 3 hypoalgesia 0.201726409833628 0.462483358950368 0.908334975369458 0.428571428571429 19.3 19 3 abnormal clavicle morphology 0.201726409833628 0.462483358950368 0.908334975369458 0.428571428571429 19.3 19 3 abnormal bile salt homeostasis 0.201726409833628 0.462483358950368 0.908334975369458 0.428571428571429 19.3 19 3 polyphagia 0.0672783614280742 0.23083437800322 0.902727969348659 0.425925925925926 19.3 19 3 abnormal T-helper 1 physiology 0.0848828233976845 0.275497554012314 0.901892883345561 0.425531914893617 19.3 19 3 impaired ovarian folliculogenesis 0.107870564208347 0.286981848629158 0.900765517241379 0.425 19.3 19 3 abnormal skeleton physiology 0.138430776453452 0.353357164112839 0.89915987460815 0.424242424242424 19.3 19 3 decreased systemic arterial blood pressure 0.138430776453452 0.353357164112839 0.89915987460815 0.424242424242424 19.3 19 3 dilated heart atrium 0.138430776453452 0.353357164112839 0.89915987460815 0.424242424242424 19.3 19 3 single kidney 0.138430776453452 0.353357164112839 0.89915987460815 0.424242424242424 19.3 19 3 abnormal T cell subpopulation ratio 0.138430776453452 0.353357164112839 0.89915987460815 0.424242424242424 19.3 19 3 decreased IgG level 0.0144400406707279 0.075918763318219 0.89742404473439 0.423423423423423 19.3 19 3 increased percent body fat/body weight 0.0776053506070437 0.25433901137684 0.896689655172414 0.423076923076923 19.3 19 3 abnormal tectorial membrane morphology 0.180162905366715 0.435736730286538 0.896689655172414 0.423076923076923 19.3 19 3 decreased circulating glycerol level 0.180162905366715 0.435736730286538 0.896689655172414 0.423076923076923 19.3 19 3 pulmonary edema 0.180162905366715 0.435736730286538 0.896689655172414 0.423076923076923 19.3 19 3 cardiomyopathy 0.098201311895117 0.277754793796333 0.89487816091954 0.422222222222222 19.3 19 3 decreased eosinophil cell number 0.0566130180261828 0.201899472889075 0.89414224137931 0.421875 19.3 19 3 flaky skin 0.239728058657353 0.501849734696051 0.892399274047187 0.421052631578947 19.3 19 3 abnormal long term depression 0.239728058657353 0.501849734696051 0.892399274047187 0.421052631578947 19.3 19 3 decreased germ cell number 0.239728058657353 0.501849734696051 0.892399274047187 0.421052631578947 19.3 19 3 abnormal neural crest cell migration 0.239728058657353 0.501849734696051 0.892399274047187 0.421052631578947 19.3 19 3 abnormal response to novelty 0.239728058657353 0.501849734696051 0.892399274047187 0.421052631578947 19.3 19 3 increased left ventricle weight 0.239728058657353 0.501849734696051 0.892399274047187 0.421052631578947 19.3 19 3 decreased liver regeneration 0.239728058657353 0.501849734696051 0.892399274047187 0.421052631578947 19.3 19 3 decreased circulating magnesium level 0.239728058657353 0.501849734696051 0.892399274047187 0.421052631578947 19.3 19 3 increased neutrophil cell number 0.0070569524275302 0.0422992028035696 0.891629964328181 0.420689655172414 19.3 19 3 teratozoospermia 0.0309342484672003 0.136555355922202 0.891131661442006 0.420454545454545 19.3 19 3 increased body length 0.0894879976681914 0.277754793796333 0.890168275862069 0.42 19.3 19 3 abnormal digestive system physiology 0.0894879976681914 0.277754793796333 0.890168275862069 0.42 19.3 19 3 kidney inflammation 0.0894879976681914 0.277754793796333 0.890168275862069 0.42 19.3 19 3 decreased circulating calcium level 0.0816263880046584 0.267165316002089 0.88631473354232 0.418181818181818 19.3 19 3 abnormal femur morphology 0.0594953197904379 0.210671494163109 0.885739577972208 0.417910447761194 19.3 19 3 hydronephrosis 0.0402269281434234 0.151269060856789 0.883103448275862 0.416666666666667 19.3 19 3 abnormal eye physiology 0.0745231755804828 0.247495007536271 0.883103448275862 0.416666666666667 19.3 19 3 abnormal kidney physiology 0.103149823712737 0.277754793796333 0.883103448275862 0.416666666666667 19.3 19 3 renal hypoplasia 0.145478966961487 0.369264214608878 0.883103448275862 0.416666666666667 19.3 19 3 abnormal adrenal gland morphology 0.21194705104281 0.481477889926019 0.883103448275862 0.416666666666667 19.3 19 3 decreased metastatic potential 0.21194705104281 0.481477889926019 0.883103448275862 0.416666666666667 19.3 19 3 abnormal startle reflex 0.21194705104281 0.481477889926019 0.883103448275862 0.416666666666667 19.3 19 3 abnormal vasodilation 0.21194705104281 0.481477889926019 0.883103448275862 0.416666666666667 19.3 19 3 decreased fatty acid level 0.21194705104281 0.481477889926019 0.883103448275862 0.416666666666667 19.3 19 3 abnormal truncus arteriosus septation 0.21194705104281 0.481477889926019 0.883103448275862 0.416666666666667 19.3 19 3 abnormal mineral level 0.332336424619559 0.551124570827436 0.883103448275862 0.416666666666667 19.3 19 3 abnormal esophagus morphology 0.332336424619559 0.551124570827436 0.883103448275862 0.416666666666667 19.3 19 3 increased papilloma incidence 0.332336424619559 0.551124570827436 0.883103448275862 0.416666666666667 19.3 19 3 altered tumor susceptibility 0.332336424619559 0.551124570827436 0.883103448275862 0.416666666666667 19.3 19 3 increased growth rate 0.332336424619559 0.551124570827436 0.883103448275862 0.416666666666667 19.3 19 3 abnormal gastrocnemius morphology 0.332336424619559 0.551124570827436 0.883103448275862 0.416666666666667 19.3 19 3 abnormal aorta elastic fiber morphology 0.332336424619559 0.551124570827436 0.883103448275862 0.416666666666667 19.3 19 3 increased fear-related response 0.332336424619559 0.551124570827436 0.883103448275862 0.416666666666667 19.3 19 3 vestibular saccular macula degeneration 0.332336424619559 0.551124570827436 0.883103448275862 0.416666666666667 19.3 19 3 small parietal bone 0.332336424619559 0.551124570827436 0.883103448275862 0.416666666666667 19.3 19 3 abnormal anogenital distance 0.332336424619559 0.551124570827436 0.883103448275862 0.416666666666667 19.3 19 3 abnormal amacrine cell morphology 0.332336424619559 0.551124570827436 0.883103448275862 0.416666666666667 19.3 19 3 hydrometra 0.332336424619559 0.551124570827436 0.883103448275862 0.416666666666667 19.3 19 3 obese 0.0499717979912813 0.183882910507858 0.880809673085535 0.415584415584416 19.3 19 3 decreased monocyte cell number 0.0680959153762102 0.233478414194794 0.880386206896552 0.415384615384615 19.3 19 3 impaired fertilization 0.0622721120361945 0.21878796425146 0.878057142857143 0.414285714285714 19.3 19 3 thick epidermis 0.0622721120361945 0.21878796425146 0.878057142857143 0.414285714285714 19.3 19 3 dehydration 0.0622721120361945 0.21878796425146 0.878057142857143 0.414285714285714 19.3 19 3 decreased granulocyte number 0.188719468008092 0.440454285649318 0.877013079667063 0.413793103448276 19.3 19 3 hydroureter 0.285558274793525 0.533924775311575 0.872713995943205 0.411764705882353 19.3 19 3 increased incidence of corneal inflammation 0.285558274793525 0.533924775311575 0.872713995943205 0.411764705882353 19.3 19 3 abnormal duodenum morphology 0.285558274793525 0.533924775311575 0.872713995943205 0.411764705882353 19.3 19 3 increased circulating magnesium level 0.285558274793525 0.533924775311575 0.872713995943205 0.411764705882353 19.3 19 3 abnormal survival 0.285558274793525 0.533924775311575 0.872713995943205 0.411764705882353 19.3 19 3 abnormal cell cytoskeleton morphology 0.285558274793525 0.533924775311575 0.872713995943205 0.411764705882353 19.3 19 3 abnormal dendritic cell physiology 0.0299495701854828 0.133272908472967 0.871548823718982 0.411214953271028 19.3 19 3 increased B cell number 0.0253312738037877 0.116364808101426 0.86951724137931 0.41025641025641 19.3 19 3 increased autoantibody level 0.151794367867498 0.377987389854981 0.86951724137931 0.41025641025641 19.3 19 3 decreased B-1 B cell number 0.151794367867498 0.377987389854981 0.86951724137931 0.41025641025641 19.3 19 3 abnormal response to injury 0.151794367867498 0.377987389854981 0.86951724137931 0.41025641025641 19.3 19 3 increased body size 0.24956499092589 0.515608733329029 0.867047021943574 0.409090909090909 19.3 19 3 decreased circulating estradiol level 0.24956499092589 0.515608733329029 0.867047021943574 0.409090909090909 19.3 19 3 abnormal mesenteric lymph node morphology 0.24956499092589 0.515608733329029 0.867047021943574 0.409090909090909 19.3 19 3 pulmonary vascular congestion 0.24956499092589 0.515608733329029 0.867047021943574 0.409090909090909 19.3 19 3 impaired humoral immune response 0.24956499092589 0.515608733329029 0.867047021943574 0.409090909090909 19.3 19 3 abnormal CD4-positive, alpha-beta T cell physiology 0.0739616074485924 0.247495007536271 0.86569014084507 0.408450704225352 19.3 19 3 abnormal single cell response 0.220410247854353 0.499790785357978 0.863478927203065 0.407407407407407 19.3 19 3 increased bone mineral density 0.0323236317020925 0.137892855749585 0.862784253890754 0.407079646017699 19.3 19 3 increased circulating follicle stimulating hormone level 0.196074318718645 0.450979997977465 0.861025862068966 0.40625 19.3 19 3 abnormal diaphragm morphology 0.196074318718645 0.450979997977465 0.861025862068966 0.40625 19.3 19 3 abnormal food intake 0.0841621928525295 0.274381985217126 0.860065967016492 0.405797101449275 19.3 19 3 decreased T cell proliferation 0.0179960716790947 0.0863360237256473 0.85923578751165 0.405405405405405 19.3 19 3 increased brown adipose tissue amount 0.175357847657421 0.424941691230234 0.85923578751165 0.405405405405405 19.3 19 3 increased white adipose tissue amount 0.175357847657421 0.424941691230234 0.85923578751165 0.405405405405405 19.3 19 3 skin inflammation 0.175357847657421 0.424941691230234 0.85923578751165 0.405405405405405 19.3 19 3 abnormal vibrissa morphology 0.15747743364399 0.385556216721874 0.857871921182266 0.404761904761905 19.3 19 3 abnormal muscle morphology 0.15747743364399 0.385556216721874 0.857871921182266 0.404761904761905 19.3 19 3 abnormal hair growth 0.128184561836848 0.32974053523181 0.855931034482759 0.403846153846154 19.3 19 3 increased susceptibility to injury 0.128184561836848 0.32974053523181 0.855931034482759 0.403846153846154 19.3 19 3 abnormal T-helper 2 physiology 0.132341785853677 0.339411280758955 0.847779310344828 0.4 19.3 19 3 irregular heartbeat 0.162611378396638 0.3965645134918 0.847779310344828 0.4 19.3 19 3 abnormal female reproductive system morphology 0.181076903640266 0.43773449738111 0.847779310344828 0.4 19.3 19 3 abnormal hair cycle 0.22751390512958 0.501849734696051 0.847779310344828 0.4 19.3 19 3 abnormal energy expenditure 0.257435979282022 0.528163513281006 0.847779310344828 0.4 19.3 19 3 abnormal hair texture 0.294117652836789 0.533924775311575 0.847779310344828 0.4 19.3 19 3 vagina atresia 0.341036400434367 0.564047902979047 0.847779310344828 0.4 19.3 19 3 increased airway responsiveness 0.341036400434367 0.564047902979047 0.847779310344828 0.4 19.3 19 3 altered righting response 0.341036400434367 0.564047902979047 0.847779310344828 0.4 19.3 19 3 abnormal dendritic cell morphology 0.341036400434367 0.564047902979047 0.847779310344828 0.4 19.3 19 3 abnormal Muller cell morphology 0.341036400434367 0.564047902979047 0.847779310344828 0.4 19.3 19 3 liver vascular congestion 0.341036400434367 0.564047902979047 0.847779310344828 0.4 19.3 19 3 ostium primum atrial septal defect 0.341036400434367 0.564047902979047 0.847779310344828 0.4 19.3 19 3 decreased trabecular bone mass 0.341036400434367 0.564047902979047 0.847779310344828 0.4 19.3 19 3 abnormal homeostasis 0.186178178193768 0.440454285649318 0.83792141138733 0.395348837209302 19.3 19 3 abnormal retinal outer nuclear layer morphology 0.208019823295193 0.476253392035703 0.836624319419238 0.394736842105263 19.3 19 3 abnormal stria vascularis morphology 0.263845394929626 0.533924775311575 0.83264039408867 0.392857142857143 19.3 19 3 abnormal ovulation 0.263845394929626 0.533924775311575 0.83264039408867 0.392857142857143 19.3 19 3 abnormal spleen germinal center morphology 0.263845394929626 0.533924775311575 0.83264039408867 0.392857142857143 19.3 19 3 failure of blastocyst to hatch from the zona pellucida 0.263845394929626 0.533924775311575 0.83264039408867 0.392857142857143 19.3 19 3 decreased IgM level 0.083024586615614 0.27156299698401 0.830299324564522 0.391752577319588 19.3 19 3 blistering 0.300645437483846 0.533924775311575 0.829349325337331 0.391304347826087 19.3 19 3 failure of embryo implantation 0.300645437483846 0.533924775311575 0.829349325337331 0.391304347826087 19.3 19 3 decreased epididymis weight 0.300645437483846 0.533924775311575 0.829349325337331 0.391304347826087 19.3 19 3 dilated heart 0.300645437483846 0.533924775311575 0.829349325337331 0.391304347826087 19.3 19 3 abnormal hepatocyte physiology 0.300645437483846 0.533924775311575 0.829349325337331 0.391304347826087 19.3 19 3 abnormal response/metabolism to endogenous compounds 0.10954978635118 0.291137920457862 0.827101766190076 0.390243902439024 19.3 19 3 abnormal colon morphology 0.158240404240243 0.386283616827874 0.826225599064874 0.389830508474576 19.3 19 3 underdeveloped hair follicles 0.346894197238244 0.572404189472725 0.824229885057471 0.388888888888889 19.3 19 3 abnormal mammary gland morphology 0.346894197238244 0.572404189472725 0.824229885057471 0.388888888888889 19.3 19 3 blepharoptosis 0.346894197238244 0.572404189472725 0.824229885057471 0.388888888888889 19.3 19 3 increased circulating glycerol level 0.346894197238244 0.572404189472725 0.824229885057471 0.388888888888889 19.3 19 3 decreased heart rate variability 0.346894197238244 0.572404189472725 0.824229885057471 0.388888888888889 19.3 19 3 decreased pulmonary respiratory rate 0.346894197238244 0.572404189472725 0.824229885057471 0.388888888888889 19.3 19 3 abnormal macrophage chemotaxis 0.346894197238244 0.572404189472725 0.824229885057471 0.388888888888889 19.3 19 3 increased eosinophil cell number 0.161565763983212 0.394207786079687 0.820431590656285 0.387096774193548 19.3 19 3 abnormal cranial ganglia morphology 0.269136301331282 0.533924775311575 0.820431590656285 0.387096774193548 19.3 19 3 abnormal podocyte morphology 0.269136301331282 0.533924775311575 0.820431590656285 0.387096774193548 19.3 19 3 hypertension 0.217238328147899 0.492822928652895 0.818877742946709 0.386363636363636 19.3 19 3 abnormal photoreceptor outer segment morphology 0.217238328147899 0.492822928652895 0.818877742946709 0.386363636363636 19.3 19 3 decreased sensitivity to induced morbidity/mortality 0.217238328147899 0.492822928652895 0.818877742946709 0.386363636363636 19.3 19 3 abnormal leukocyte migration 0.198569401674022 0.456296892992268 0.815172413793103 0.384615384615385 19.3 19 3 decreased body temperature 0.198569401674022 0.456296892992268 0.815172413793103 0.384615384615385 19.3 19 3 decreased Peyer's patch number 0.305731650479089 0.533924775311575 0.815172413793103 0.384615384615385 19.3 19 3 short hair 0.408447551632859 0.631371263463595 0.815172413793103 0.384615384615385 19.3 19 3 small trigeminal ganglion 0.408447551632859 0.631371263463595 0.815172413793103 0.384615384615385 19.3 19 3 excessive scratching 0.408447551632859 0.631371263463595 0.815172413793103 0.384615384615385 19.3 19 3 increased circulating adrenocorticotropin level 0.408447551632859 0.631371263463595 0.815172413793103 0.384615384615385 19.3 19 3 abnormal dopaminergic neuron morphology 0.408447551632859 0.631371263463595 0.815172413793103 0.384615384615385 19.3 19 3 abnormal GABAergic neuron morphology 0.408447551632859 0.631371263463595 0.815172413793103 0.384615384615385 19.3 19 3 decreased follicle stimulating hormone level 0.408447551632859 0.631371263463595 0.815172413793103 0.384615384615385 19.3 19 3 increased renin activity 0.408447551632859 0.631371263463595 0.815172413793103 0.384615384615385 19.3 19 3 increased prostaglandin level 0.408447551632859 0.631371263463595 0.815172413793103 0.384615384615385 19.3 19 3 increased systemic arterial blood pressure 0.221076787597179 0.501073812435519 0.811703595011005 0.382978723404255 19.3 19 3 decreased susceptibility to injury 0.167499238016327 0.408284521867334 0.810377281947262 0.382352941176471 19.3 19 3 decreased pancreatic beta cell number 0.273550853102566 0.533924775311575 0.810377281947262 0.382352941176471 19.3 19 3 increased width of hypertrophic chondrocyte zone 0.273550853102566 0.533924775311575 0.810377281947262 0.382352941176471 19.3 19 3 decreased regulatory T cell number 0.273550853102566 0.533924775311575 0.810377281947262 0.382352941176471 19.3 19 3 increased susceptibility to viral infection induced morbidity/mortality 0.273550853102566 0.533924775311575 0.810377281947262 0.382352941176471 19.3 19 3 skin lesions 0.185095874419705 0.440454285649318 0.807408866995074 0.380952380952381 19.3 19 3 abnormal circulating glucose level 0.309755683603897 0.533924775311575 0.803928656361474 0.379310344827586 19.3 19 3 enlarged epididymis 0.309755683603897 0.533924775311575 0.803928656361474 0.379310344827586 19.3 19 3 increased insulin secretion 0.277265256591881 0.533924775311575 0.80195340167754 0.378378378378378 19.3 19 3 abnormal NK cell physiology 0.207750631622328 0.475856073812652 0.799136235161108 0.377049180327869 19.3 19 3 paternal imprinting 0.409369049883305 0.631371263463595 0.794793103448276 0.375 19.3 19 3 abnormal epididymis epithelium morphology 0.409369049883305 0.631371263463595 0.794793103448276 0.375 19.3 19 3 abnormal amnion morphology 0.409369049883305 0.631371263463595 0.794793103448276 0.375 19.3 19 3 sepsis 0.409369049883305 0.631371263463595 0.794793103448276 0.375 19.3 19 3 decreased circulating prolactin level 0.409369049883305 0.631371263463595 0.794793103448276 0.375 19.3 19 3 increased circulating estradiol level 0.409369049883305 0.631371263463595 0.794793103448276 0.375 19.3 19 3 small lymph nodes 0.353864469348467 0.583518639379723 0.794793103448276 0.375 19.3 19 3 increased circulating total protein level 0.353864469348467 0.583518639379723 0.794793103448276 0.375 19.3 19 3 increased B cell proliferation 0.232765948401591 0.501849734696051 0.790302746931619 0.372881355932203 19.3 19 3 impaired macrophage phagocytosis 0.283088477539558 0.533924775311575 0.78863191659984 0.372093023255814 19.3 19 3 impaired behavioral response to xenobiotic 0.315564487040721 0.533924775311575 0.787223645320197 0.371428571428571 19.3 19 3 cryptorchism 0.35592071084658 0.586714889483677 0.784980842911877 0.37037037037037 19.3 19 3 abnormal cytokine secretion 0.109421109227364 0.290951372745129 0.784471115091805 0.37012987012987 19.3 19 3 abnormal nail morphology 0.409407778077097 0.631371263463595 0.780849364791289 0.368421052631579 19.3 19 3 abnormal ear morphology 0.409407778077097 0.631371263463595 0.780849364791289 0.368421052631579 19.3 19 3 abnormal behavioral response to xenobiotic 0.409407778077097 0.631371263463595 0.780849364791289 0.368421052631579 19.3 19 3 shortened RR interval 0.409407778077097 0.631371263463595 0.780849364791289 0.368421052631579 19.3 19 3 thin interventricular septum 0.409407778077097 0.631371263463595 0.780849364791289 0.368421052631579 19.3 19 3 abnormal estrous cycle 0.357369344825871 0.588907747767045 0.777131034482759 0.366666666666667 19.3 19 3 abnormal T cell activation 0.241928273944422 0.501849734696051 0.773312208760485 0.364864864864865 19.3 19 3 abnormal urine homeostasis 0.206078036447651 0.472242391214677 0.772715517241379 0.364583333333333 19.3 19 3 abnormal long bone epiphysis morphology 0.408921694635085 0.631371263463595 0.770708463949843 0.363636363636364 19.3 19 3 parakeratosis 0.408921694635085 0.631371263463595 0.770708463949843 0.363636363636364 19.3 19 3 diarrhea 0.358362559303348 0.590348918057667 0.770708463949843 0.363636363636364 19.3 19 3 abnormal immune system physiology 0.179449328537613 0.434644795265154 0.769154616240267 0.362903225806452 19.3 19 3 abnormal epidermis stratum granulosum morphology 0.359006412154661 0.591213803531758 0.76535632183908 0.361111111111111 19.3 19 3 impaired conditioned place preference behavior 0.408105495010842 0.631371263463595 0.763001379310345 0.36 19.3 19 3 small lens 0.35937713413832 0.591432762930248 0.760827586206897 0.358974358974359 19.3 19 3 absent atrioventricular cushions 0.483145680419896 0.732816312433857 0.756945812807882 0.357142857142857 19.3 19 3 abnormal spleen periarteriolar lymphoid sheath morphology 0.483145680419896 0.732816312433857 0.756945812807882 0.357142857142857 19.3 19 3 abnormal hair cuticle 0.483145680419896 0.732816312433857 0.756945812807882 0.357142857142857 19.3 19 3 skeletal muscle necrosis 0.483145680419896 0.732816312433857 0.756945812807882 0.357142857142857 19.3 19 3 abnormal iris pigmentation 0.483145680419896 0.732816312433857 0.756945812807882 0.357142857142857 19.3 19 3 increased circulating growth hormone level 0.483145680419896 0.732816312433857 0.756945812807882 0.357142857142857 19.3 19 3 abnormal glucose tolerance 0.483145680419896 0.732816312433857 0.756945812807882 0.357142857142857 19.3 19 3 decreased tongue size 0.483145680419896 0.732816312433857 0.756945812807882 0.357142857142857 19.3 19 3 increased lung compliance 0.483145680419896 0.732816312433857 0.756945812807882 0.357142857142857 19.3 19 3 abnormal retinal photoreceptor layer morphology 0.405897518747895 0.630469040731789 0.752062291434928 0.354838709677419 19.3 19 3 abnormal T cell proliferation 0.405897518747895 0.630469040731789 0.752062291434928 0.354838709677419 19.3 19 3 decreased susceptibility to bacterial infection induced morbidity/mortality 0.405897518747895 0.630469040731789 0.752062291434928 0.354838709677419 19.3 19 3 abnormal intestine physiology 0.405897518747895 0.630469040731789 0.752062291434928 0.354838709677419 19.3 19 3 abnormal hair shaft morphology 0.359347452014811 0.591432762930248 0.750637931034483 0.354166666666667 19.3 19 3 thin skin 0.40462348995832 0.630469040731789 0.748040567951318 0.352941176470588 19.3 19 3 abnormal skin physiology 0.40462348995832 0.630469040731789 0.748040567951318 0.352941176470588 19.3 19 3 enlarged sebaceous gland 0.476902199932276 0.730476737888877 0.748040567951318 0.352941176470588 19.3 19 3 increased aggression towards mice 0.476902199932276 0.730476737888877 0.748040567951318 0.352941176470588 19.3 19 3 aminoaciduria 0.476902199932276 0.730476737888877 0.748040567951318 0.352941176470588 19.3 19 3 increased regulatory T cell number 0.476902199932276 0.730476737888877 0.748040567951318 0.352941176470588 19.3 19 3 delayed heart development 0.476902199932276 0.730476737888877 0.748040567951318 0.352941176470588 19.3 19 3 abnormal dopamine level 0.471487076283417 0.72351887862739 0.741806896551724 0.35 19.3 19 3 abnormal fibula morphology 0.471487076283417 0.72351887862739 0.741806896551724 0.35 19.3 19 3 abnormal male reproductive system physiology 0.471487076283417 0.72351887862739 0.741806896551724 0.35 19.3 19 3 abnormal thymocyte activation 0.471487076283417 0.72351887862739 0.741806896551724 0.35 19.3 19 3 kidney atrophy 0.471487076283417 0.72351887862739 0.741806896551724 0.35 19.3 19 3 enhanced behavioral response to xenobiotic 0.471487076283417 0.72351887862739 0.741806896551724 0.35 19.3 19 3 abnormal intestinal mucosa morphology 0.400482263992532 0.628120827037468 0.73934242181235 0.348837209302326 19.3 19 3 abnormal crista ampullaris morphology 0.466669031782412 0.717453162273641 0.73719940029985 0.347826086956522 19.3 19 3 abnormal B cell morphology 0.466669031782412 0.717453162273641 0.73719940029985 0.347826086956522 19.3 19 3 abnormal kidney cortex morphology 0.462303412704124 0.711181038405386 0.733655172413793 0.346153846153846 19.3 19 3 abnormal CD8-positive, alpha-beta T cell physiology 0.458293653886344 0.705230723193493 0.730844233055886 0.344827586206897 19.3 19 3 increased double-positive T cell number 0.458293653886344 0.705230723193493 0.730844233055886 0.344827586206897 19.3 19 3 abnormal crypts of Lieberkuhn morphology 0.454572009525958 0.699936783470022 0.728560344827586 0.34375 19.3 19 3 decreased threshold for auditory brainstem response 0.447807583027335 0.68994819620966 0.72507441016334 0.342105263157895 19.3 19 3 abnormal gametogenesis 0.441740089677571 0.680810702027855 0.722539184952978 0.340909090909091 19.3 19 3 abnormal coat/ hair morphology 0.433597086976526 0.668467774313051 0.719812621990891 0.339622641509434 19.3 19 3 increased susceptibility to bacterial infection induced morbidity/mortality 0.45193864315904 0.696097445732578 0.70648275862069 0.333333333333333 19.3 19 3 acanthosis 0.492022807471843 0.732816312433857 0.70648275862069 0.333333333333333 19.3 19 3 abnormal spleen marginal zone morphology 0.508755808416582 0.732816312433857 0.70648275862069 0.333333333333333 19.3 19 3 abnormal lens fiber morphology 0.492022807471843 0.732816312433857 0.70648275862069 0.333333333333333 19.3 19 3 abnormal leukocyte adhesion 0.492022807471843 0.732816312433857 0.70648275862069 0.333333333333333 19.3 19 3 head tilt 0.497130378969575 0.732816312433857 0.70648275862069 0.333333333333333 19.3 19 3 abnormal stomach glandular epithelium morphology 0.541906201279292 0.736205175140491 0.70648275862069 0.333333333333333 19.3 19 3 cortical renal glomerulopathies 0.541906201279292 0.736205175140491 0.70648275862069 0.333333333333333 19.3 19 3 abnormal retinal rod cell morphology 0.541906201279292 0.736205175140491 0.70648275862069 0.333333333333333 19.3 19 3 thick dermal layer 0.541906201279292 0.736205175140491 0.70648275862069 0.333333333333333 19.3 19 3 abnormal iron level 0.541906201279292 0.736205175140491 0.70648275862069 0.333333333333333 19.3 19 3 decreased fluid intake 0.541906201279292 0.736205175140491 0.70648275862069 0.333333333333333 19.3 19 3 impaired leukocyte tethering or rolling 0.541906201279292 0.736205175140491 0.70648275862069 0.333333333333333 19.3 19 3 interdigital webbing 0.554200320412661 0.751675734474642 0.70648275862069 0.333333333333333 19.3 19 3 decreased salivation 0.554200320412661 0.751675734474642 0.70648275862069 0.333333333333333 19.3 19 3 dilated ureter 0.554200320412661 0.751675734474642 0.70648275862069 0.333333333333333 19.3 19 3 lactation failure 0.554200320412661 0.751675734474642 0.70648275862069 0.333333333333333 19.3 19 3 abnormal microglial cell activation 0.554200320412661 0.751675734474642 0.70648275862069 0.333333333333333 19.3 19 3 abnormal thrombosis 0.474770288366846 0.728332465194283 0.70648275862069 0.333333333333333 19.3 19 3 increased circulating calcium level 0.508188646432076 0.732816312433857 0.693637617554859 0.327272727272727 19.3 19 3 abnormal body temperature homeostasis 0.557735946354052 0.756265013112949 0.683692992213571 0.32258064516129 19.3 19 3 reddish skin 0.566852126553531 0.76841671106371 0.681251231527094 0.321428571428571 19.3 19 3 abnormal inflammatory response 0.552440567667397 0.750311718303385 0.677045977011494 0.319444444444444 19.3 19 3 arrested B cell differentiation 0.577535489633228 0.780347382108993 0.672020185029437 0.317073170731707 19.3 19 3 shiny skin 0.603059319680305 0.808902700299142 0.66929945553539 0.315789473684211 19.3 19 3 decreased grooming behavior 0.603059319680305 0.808902700299142 0.66929945553539 0.315789473684211 19.3 19 3 decreased chemically-elicited antinociception 0.603059319680305 0.808902700299142 0.66929945553539 0.315789473684211 19.3 19 3 impaired natural killer cell mediated cytotoxicity 0.580342544183359 0.78392727594684 0.66929945553539 0.315789473684211 19.3 19 3 abnormal humoral immune response 0.591305741179921 0.793779293677849 0.666112315270936 0.314285714285714 19.3 19 3 reduced male mating frequency 0.620032716107822 0.824531551668422 0.662327586206897 0.3125 19.3 19 3 abnormal level of surface class II molecules 0.620032716107822 0.824531551668422 0.662327586206897 0.3125 19.3 19 3 decreased circulating growth hormone level 0.620032716107822 0.824531551668422 0.662327586206897 0.3125 19.3 19 3 abnormal fertilization 0.620032716107822 0.824531551668422 0.662327586206897 0.3125 19.3 19 3 abnormal urinary bladder physiology 0.620032716107822 0.824531551668422 0.662327586206897 0.3125 19.3 19 3 stomach inflammation 0.615703439253765 0.824531551668422 0.657759809750297 0.310344827586207 19.3 19 3 abnormal cytotoxic T cell physiology 0.61799360278545 0.824531551668422 0.656019704433498 0.30952380952381 19.3 19 3 decreased inflammatory response 0.626051561031571 0.82813254882533 0.656019704433498 0.30952380952381 19.3 19 3 abnormal reflex 0.63764456170507 0.843243406295249 0.647609195402299 0.305555555555556 19.3 19 3 abnormal retinal cone cell morphology 0.642606990517836 0.846430971095112 0.645049475262369 0.304347826086957 19.3 19 3 increased susceptibility to fungal infection 0.642606990517836 0.846430971095112 0.645049475262369 0.304347826086957 19.3 19 3 abnormal vascular regression 0.659447423993257 0.86404174511167 0.635834482758621 0.3 19.3 19 3 abnormal Peyer's patch T cell area morphology 0.659447423993257 0.86404174511167 0.635834482758621 0.3 19.3 19 3 distended urinary bladder 0.679670431180968 0.86404174511167 0.623367139959432 0.294117647058824 19.3 19 3 abnormal heart rate 0.679670431180968 0.86404174511167 0.623367139959432 0.294117647058824 19.3 19 3 abnormal tendon morphology 0.679670431180968 0.86404174511167 0.623367139959432 0.294117647058824 19.3 19 3 abnormal oocyte morphology 0.690365478140671 0.868631323659545 0.623367139959432 0.294117647058824 19.3 19 3 decreased cytotoxic T cell cytolysis 0.690365478140671 0.868631323659545 0.623367139959432 0.294117647058824 19.3 19 3 abnormal cellular extravasation 0.691827563613669 0.870250854356006 0.618172413793103 0.291666666666667 19.3 19 3 autoimmune response 0.704002671205323 0.885342085249363 0.615323692992214 0.290322580645161 19.3 19 3 increased circulating luteinizing hormone level 0.719227583927887 0.897006074214398 0.605556650246305 0.285714285714286 19.3 19 3 decreased circulating progesterone level 0.719227583927887 0.897006074214398 0.605556650246305 0.285714285714286 19.3 19 3 increased keratinocyte proliferation 0.71052890829595 0.888992711795512 0.605556650246305 0.285714285714286 19.3 19 3 decreased susceptibility to induced arthritis 0.782476270181828 0.948842479128336 0.594932849364791 0.280701754385965 19.3 19 3 abnormal feces composition 0.736415498305635 0.91633856598266 0.593445517241379 0.28 19.3 19 3 abnormal Peyer's patch follicle morphology 0.732656673450842 0.913296655078412 0.588735632183908 0.277777777777778 19.3 19 3 increased susceptibility to autoimmune disorder 0.732656673450842 0.913296655078412 0.588735632183908 0.277777777777778 19.3 19 3 increased activated T cell number 0.75607950318798 0.938965433939142 0.578031347962383 0.272727272727273 19.3 19 3 decreased susceptibility to viral infection induced morbidity/mortality 0.75607950318798 0.938965433939142 0.578031347962383 0.272727272727273 19.3 19 3 absent vibrissae 0.778112883754133 0.948842479128336 0.578031347962382 0.272727272727273 19.3 19 3 decreased IgA level 0.826544660378409 0.993491105431888 0.570620689655172 0.269230769230769 19.3 19 3 abnormal pain threshold 0.793984340652485 0.956202395242341 0.565186206896552 0.266666666666667 19.3 19 3 increased susceptibility to parasitic infection 0.888323496906489 1 0.565186206896552 0.266666666666667 19.3 19 3 abnormal photoreceptor inner segment morphology 0.778941442654606 0.948842479128336 0.557749546279492 0.263157894736842 19.3 19 3 decreased liver glycogen level 0.778941442654606 0.948842479128336 0.557749546279492 0.263157894736842 19.3 19 3 decreased skin tensile strength 0.818772782208388 0.984387286487852 0.529862068965517 0.25 19.3 19 3 increased urine calcium level 0.818772782208388 0.984387286487852 0.529862068965517 0.25 19.3 19 3 nuclear cataracts 0.818772782208388 0.984387286487852 0.529862068965517 0.25 19.3 19 3 decreased acute inflammation 0.860731481944601 1 0.508667586206897 0.24 19.3 19 3 abnormal stomach mucosa morphology 0.860731481944601 1 0.508667586206897 0.24 19.3 19 3 intestinal ulcer 0.880987077987803 1 0.481692789968652 0.227272727272727 19.3 19 3 abnormal systemic arterial blood pressure 0.92979986233929 1 0.470988505747126 0.222222222222222 19.3 19 3 decreased susceptibility to parasitic infection 0.927226249793727 1 0.463629310344828 0.21875 19.3 19 3 abnormal regulatory T cell physiology 0.904558870399178 1 0.460749625187406 0.217391304347826 19.3 19 3 increased susceptibility to induced arthritis 0.939842987338122 1 0.438506539833531 0.206896551724138 19.3 19 3 gastric polyps 0.000679441268712046 0.00786981005438897 3.30016478641146 1 19.2 19 2 decreased small intestinal villus height 0.000679441268712046 0.00786981005438897 3.30016478641146 1 19.2 19 2 fused cornea and lens 1.56757387399592e-05 0.000348155358175432 2.97014830777031 0.9 19.2 19 2 increased cochlear outer hair cell number 9.87389012979614e-08 4.4254597653816e-06 2.88764418811003 0.875 19.2 19 2 craniofacial phenotype 0.000233926114338868 0.00326905173830299 2.88764418811003 0.875 19.2 19 2 abnormal foramen magnum morphology 0.000233926114338868 0.00326905173830299 2.88764418811003 0.875 19.2 19 2 failure of atrioventricular cushion closure 0.000885261019951537 0.00959514939925685 2.82871267406697 0.857142857142857 19.2 19 2 mammary gland hyperplasia 0.000885261019951537 0.00959514939925685 2.82871267406697 0.857142857142857 19.2 19 2 abnormal Purkinje cell innervation 0.000885261019951537 0.00959514939925685 2.82871267406697 0.857142857142857 19.2 19 2 abnormal talus morphology 0.000885261019951537 0.00959514939925685 2.82871267406697 0.857142857142857 19.2 19 2 abnormal hippocampal fimbria morphology 0.00328701422648175 0.0259569774234075 2.75013732200955 0.833333333333333 19.2 19 2 esophageal atresia 0.00328701422648175 0.0259569774234075 2.75013732200955 0.833333333333333 19.2 19 2 decreased liver function 0.00328701422648175 0.0259569774234075 2.75013732200955 0.833333333333333 19.2 19 2 abnormal lambdoidal suture morphology 0.00328701422648175 0.0259569774234075 2.75013732200955 0.833333333333333 19.2 19 2 absent parietal bone 0.00328701422648175 0.0259569774234075 2.75013732200955 0.833333333333333 19.2 19 2 abnormal neural crest cell morphology 0.00328701422648175 0.0259569774234075 2.75013732200955 0.833333333333333 19.2 19 2 abnormal orbit morphology 0.00328701422648175 0.0259569774234075 2.75013732200955 0.833333333333333 19.2 19 2 abnormal intestinal enteroendocrine cell morphology 0.00328701422648175 0.0259569774234075 2.75013732200955 0.833333333333333 19.2 19 2 abnormal embryo morphology 0.00328701422648175 0.0259569774234075 2.75013732200955 0.833333333333333 19.2 19 2 abnormal sphenoid bone morphology 6.82354108878549e-05 0.00114300056958612 2.70013482524574 0.818181818181818 19.2 19 2 common atrioventricular valve 6.82354108878549e-05 0.00114300056958612 2.70013482524574 0.818181818181818 19.2 19 2 abnormal hindlimb zeugopod morphology 0.000241853726460266 0.0033238184782868 2.64013182912917 0.8 19.2 19 2 decreased circulating lactate level 0.000241853726460266 0.0033238184782868 2.64013182912917 0.8 19.2 19 2 abnormal placing response 1.90162802264828e-05 0.00040257869841171 2.59298661789472 0.785714285714286 19.2 19 2 spina bifida occulta 1.90162802264828e-05 0.00040257869841171 2.59298661789472 0.785714285714286 19.2 19 2 abnormal posterior semicircular canal morphology 0.000839477837530832 0.00928089387047976 2.56679483387558 0.777777777777778 19.2 19 2 premature bone ossification 0.000839477837530832 0.00928089387047976 2.56679483387558 0.777777777777778 19.2 19 2 decreased fear-related response 0.000839477837530832 0.00928089387047976 2.56679483387558 0.777777777777778 19.2 19 2 increased neuronal precursor cell number 0.000839477837530832 0.00928089387047976 2.56679483387558 0.777777777777778 19.2 19 2 decreased transitional stage T1 B cell number 0.000839477837530832 0.00928089387047976 2.56679483387558 0.777777777777778 19.2 19 2 iris coloboma 0.000839477837530832 0.00928089387047976 2.56679483387558 0.777777777777778 19.2 19 2 increased cochlear inner hair cell number 6.47570983395231e-05 0.00109209004826823 2.53858829723958 0.769230769230769 19.2 19 2 increased skin tumor incidence 1.41882004571389e-06 4.38424206672459e-05 2.47512358980859 0.75 19.2 19 2 abnormal mineral level 0.000216174209139144 0.00307435066213908 2.47512358980859 0.75 19.2 19 2 abnormal vitelline vein connection 0.000216174209139144 0.00307435066213908 2.47512358980859 0.75 19.2 19 2 pointed snout 0.00283926573678955 0.0236433017475975 2.47512358980859 0.75 19.2 19 2 enlarged pituitary gland 0.00283926573678955 0.0236433017475975 2.47512358980859 0.75 19.2 19 2 abnormal hypoglossal nerve morphology 0.00283926573678955 0.0236433017475975 2.47512358980859 0.75 19.2 19 2 absent eyelids 0.00283926573678955 0.0236433017475975 2.47512358980859 0.75 19.2 19 2 early eyelid opening 0.00283926573678955 0.0236433017475975 2.47512358980859 0.75 19.2 19 2 abnormal soft palate morphology 0.00283926573678955 0.0236433017475975 2.47512358980859 0.75 19.2 19 2 abnormal forelimb zeugopod morphology 0.00283926573678955 0.0236433017475975 2.47512358980859 0.75 19.2 19 2 tau protein deposits 0.00283926573678955 0.0236433017475975 2.47512358980859 0.75 19.2 19 2 small frontal bone 0.00283926573678955 0.0236433017475975 2.47512358980859 0.75 19.2 19 2 abnormal somite size 0.00283926573678955 0.0236433017475975 2.47512358980859 0.75 19.2 19 2 abnormal stomach position or orientation 0.00283926573678955 0.0236433017475975 2.47512358980859 0.75 19.2 19 2 lung situs inversus 0.00283926573678955 0.0236433017475975 2.47512358980859 0.75 19.2 19 2 premature suture closure 0.000704835901320029 0.00801663642374689 2.40011984466288 0.727272727272727 19.2 19 2 delayed hepatic development 0.000704835901320029 0.00801663642374689 2.40011984466288 0.727272727272727 19.2 19 2 loss of cortex neurons 0.000704835901320029 0.00801663642374689 2.40011984466288 0.727272727272727 19.2 19 2 abnormal eye anterior chamber morphology 1.47396325187057e-05 0.000331808469595297 2.38345234574161 0.722222222222222 19.2 19 2 abnormal aerobic respiration 1.47396325187057e-05 0.000331808469595297 2.38345234574161 0.722222222222222 19.2 19 2 pulmonary alveolar hemorrhage 0.000179109143622125 0.0026207882044708 2.35726056172247 0.714285714285714 19.2 19 2 broad head 0.00929139724280729 0.0588849697872182 2.35726056172247 0.714285714285714 19.2 19 2 retina hyperplasia 0.00929139724280729 0.0588849697872182 2.35726056172247 0.714285714285714 19.2 19 2 abnormal axial mesoderm 0.00929139724280729 0.0588849697872182 2.35726056172247 0.714285714285714 19.2 19 2 abnormal superior semicircular canal morphology 0.00929139724280729 0.0588849697872182 2.35726056172247 0.714285714285714 19.2 19 2 aorta coarctation 0.00929139724280729 0.0588849697872182 2.35726056172247 0.714285714285714 19.2 19 2 increased cell nucleus count 0.00929139724280729 0.0588849697872182 2.35726056172247 0.714285714285714 19.2 19 2 skeletal muscle interstitial fibrosis 0.00929139724280729 0.0588849697872182 2.35726056172247 0.714285714285714 19.2 19 2 retinal pigment epithelium atrophy 0.00929139724280729 0.0588849697872182 2.35726056172247 0.714285714285714 19.2 19 2 abnormal spinal cord central canal morphology 0.00929139724280729 0.0588849697872182 2.35726056172247 0.714285714285714 19.2 19 2 thick pulmonary valve 0.00929139724280729 0.0588849697872182 2.35726056172247 0.714285714285714 19.2 19 2 embryonic lethality at implantation, incomplete penetrance 0.00929139724280729 0.0588849697872182 2.35726056172247 0.714285714285714 19.2 19 2 ductus venosus stenosis 0.00929139724280729 0.0588849697872182 2.35726056172247 0.714285714285714 19.2 19 2 increased muscle cell glucose uptake 3.89091596278164e-06 0.000105202754971949 2.35726056172247 0.714285714285714 19.2 19 2 abnormal glutamate-mediated receptor currents 4.62247982977676e-05 0.000824259396169871 2.32952808452574 0.705882352941177 19.2 19 2 abnormal basioccipital bone morphology 1.20618600421921e-05 0.000279105831208863 2.31011535048802 0.7 19.2 19 2 abnormal mammary gland physiology 0.00223393409669549 0.0200249047406488 2.31011535048802 0.7 19.2 19 2 acrania 0.00223393409669549 0.0200249047406488 2.31011535048802 0.7 19.2 19 2 abnormal glial cell physiology 0.00223393409669549 0.0200249047406488 2.31011535048802 0.7 19.2 19 2 abnormal gas homeostasis 0.00223393409669549 0.0200249047406488 2.31011535048802 0.7 19.2 19 2 decreased transitional stage T2 B cell number 0.00223393409669549 0.0200249047406488 2.31011535048802 0.7 19.2 19 2 abnormal hippocampus neuron morphology 0.00223393409669549 0.0200249047406488 2.31011535048802 0.7 19.2 19 2 abnormal heart and great artery attachment 0.00223393409669549 0.0200249047406488 2.31011535048802 0.7 19.2 19 2 increased fatty acid oxidation 0.00223393409669549 0.0200249047406488 2.31011535048802 0.7 19.2 19 2 abnormal cranial nerve morphology 3.17336539460566e-06 8.81982840120846e-05 2.29576680793841 0.695652173913043 19.2 19 2 small interparietal bone 0.000556862708438291 0.00659617136781071 2.28472946751563 0.692307692307692 19.2 19 2 decreased cochlear coiling 0.00014188068433071 0.00217277620378952 2.26886329065788 0.6875 19.2 19 2 abnormal nasal septum morphology 3.66834168791436e-05 0.000687575248240316 2.25800748543942 0.684210526315789 19.2 19 2 embryonic lethality between implantation and somite formation, incomplete penetrance 3.66834168791436e-05 0.000687575248240316 2.25800748543942 0.684210526315789 19.2 19 2 abnormal cochlear sensory epithelium morphology 9.58476470407508e-06 0.000230358475375717 2.25011235437145 0.681818181818182 19.2 19 2 abnormal postnatal growth/weight/body size 1.78081590364508e-07 7.144805742447e-06 2.23559550047228 0.67741935483871 19.2 19 2 malocclusion 1.27670696403757e-08 6.68591278535466e-07 2.22984107189963 0.675675675675676 19.2 19 2 right pulmonary isomerism 0.000109195129855891 0.00171370905688662 2.20010985760764 0.666666666666667 19.2 19 2 abnormal mammary gland morphology 0.000109195129855891 0.00171370905688662 2.20010985760764 0.666666666666667 19.2 19 2 abnormal NMDA-mediated synaptic currents 0.00683884153530697 0.0459773468083138 2.20010985760764 0.666666666666667 19.2 19 2 premature neuronal precursor differentiation 0.00683884153530697 0.0459773468083138 2.20010985760764 0.666666666666667 19.2 19 2 decreased vestibular hair cell number 0.00683884153530697 0.0459773468083138 2.20010985760764 0.666666666666667 19.2 19 2 small scapula 0.00683884153530697 0.0459773468083138 2.20010985760764 0.666666666666667 19.2 19 2 decreased cochlear hair cell number 0.00683884153530697 0.0459773468083138 2.20010985760764 0.666666666666667 19.2 19 2 eye opacity 0.00683884153530697 0.0459773468083138 2.20010985760764 0.666666666666667 19.2 19 2 abnormal hyoid bone lesser horn morphology 0.00683884153530697 0.0459773468083138 2.20010985760764 0.666666666666667 19.2 19 2 cerebellum atrophy 0.00683884153530697 0.0459773468083138 2.20010985760764 0.666666666666667 19.2 19 2 abnormal brain vasculature morphology 5.23380436328393e-07 1.88682439908243e-05 2.20010985760764 0.666666666666667 19.2 19 2 abnormal glial cell morphology 0.000424899608207907 0.00535158367299832 2.20010985760764 0.666666666666667 19.2 19 2 abnormal placenta size 0.000424899608207907 0.00535158367299832 2.20010985760764 0.666666666666667 19.2 19 2 mesocardia 0.0016821592856818 0.0161871227200522 2.20010985760764 0.666666666666667 19.2 19 2 abnormal glossopharyngeal nerve morphology 0.0016821592856818 0.0161871227200522 2.20010985760764 0.666666666666667 19.2 19 2 abnormal thymus involution 0.0016821592856818 0.0161871227200522 2.20010985760764 0.666666666666667 19.2 19 2 abnormal AMPA-mediated synaptic currents 0.0016821592856818 0.0161871227200522 2.20010985760764 0.666666666666667 19.2 19 2 absent ovary 0.0016821592856818 0.0161871227200522 2.20010985760764 0.666666666666667 19.2 19 2 increased osteosarcoma incidence 0.0016821592856818 0.0161871227200522 2.20010985760764 0.666666666666667 19.2 19 2 small parietal bone 0.0016821592856818 0.0161871227200522 2.20010985760764 0.666666666666667 19.2 19 2 abnormal cell differentiation 7.81735510691546e-09 4.48815155805538e-07 2.17327924958803 0.658536585365854 19.2 19 2 short sternum 1.51478738974643e-06 4.6233541496862e-05 2.1621769290282 0.655172413793103 19.2 19 2 abnormal xiphoid process morphology 5.70499177094416e-06 0.000147058725701799 2.15780005265365 0.653846153846154 19.2 19 2 anencephaly 8.24091652906254e-05 0.00133982221346687 2.14510711116745 0.65 19.2 19 2 abnormal cranial suture morphology 0.000317249808724437 0.004186519359162 2.13540074414859 0.647058823529412 19.2 19 2 abnormal embryonic-extraembryonic boundary morphology 0.000317249808724437 0.004186519359162 2.13540074414859 0.647058823529412 19.2 19 2 increased hepatoma incidence 0.000317249808724437 0.004186519359162 2.13540074414859 0.647058823529412 19.2 19 2 abnormal somite shape 4.31192150071679e-06 0.0001159557268436 2.12153450555022 0.642857142857143 19.2 19 2 abnormal kidney blood vessel morphology 0.00123681912510739 0.0127131717921679 2.12153450555022 0.642857142857143 19.2 19 2 increased lactate dehydrogenase level 0.00123681912510739 0.0127131717921679 2.12153450555022 0.642857142857143 19.2 19 2 amyloid beta deposits 0.00123681912510739 0.0127131717921679 2.12153450555022 0.642857142857143 19.2 19 2 absent olfactory bulb 0.00123681912510739 0.0127131717921679 2.12153450555022 0.642857142857143 19.2 19 2 abnormal sagittal suture morphology 0.00123681912510739 0.0127131717921679 2.12153450555022 0.642857142857143 19.2 19 2 decreased CNS synapse formation 0.00123681912510739 0.0127131717921679 2.12153450555022 0.642857142857143 19.2 19 2 lysosomal protein accumulation 0.00123681912510739 0.0127131717921679 2.12153450555022 0.642857142857143 19.2 19 2 abnormal basisphenoid bone morphology 6.13369693206539e-05 0.00104503911770635 2.10010486408002 0.636363636363636 19.2 19 2 abnormal eye distance/ position 0.00490985593860254 0.0355553614185555 2.10010486408002 0.636363636363636 19.2 19 2 retinal detachment 0.00490985593860254 0.0355553614185555 2.10010486408002 0.636363636363636 19.2 19 2 abnormal spinal cord ventral horn morphology 0.00490985593860254 0.0355553614185555 2.10010486408002 0.636363636363636 19.2 19 2 abnormal dorsal-ventral polarity of the somites 0.00490985593860254 0.0355553614185555 2.10010486408002 0.636363636363636 19.2 19 2 abnormal palate development 0.00490985593860254 0.0355553614185555 2.10010486408002 0.636363636363636 19.2 19 2 palatal shelf hypoplasia 0.00490985593860254 0.0355553614185555 2.10010486408002 0.636363636363636 19.2 19 2 abnormal pulmonary alveolar sac morphology 0.00490985593860254 0.0355553614185555 2.10010486408002 0.636363636363636 19.2 19 2 kyphoscoliosis 0.000233500923530315 0.00326905173830299 2.08431460194408 0.631578947368421 19.2 19 2 ocular hypertelorism 4.51919610130997e-05 0.000813481388853436 2.06260299150716 0.625 19.2 19 2 abnormal nursing 4.51919610130997e-05 0.000813481388853436 2.06260299150716 0.625 19.2 19 2 abnormal epicardium morphology 0.000896597814669902 0.00967586578738126 2.06260299150716 0.625 19.2 19 2 abnormal amnion morphology 0.000896597814669902 0.00967586578738126 2.06260299150716 0.625 19.2 19 2 dermal cysts 0.0200449497528368 0.0993498393183675 2.06260299150716 0.625 19.2 19 2 decreased aerobic running capacity 0.0200449497528368 0.0993498393183675 2.06260299150716 0.625 19.2 19 2 altered response to CNS ischemic injury 0.0200449497528368 0.0993498393183675 2.06260299150716 0.625 19.2 19 2 elevated level of mitotic sister chromatid exchange 0.0200449497528368 0.0993498393183675 2.06260299150716 0.625 19.2 19 2 absent interparietal bone 0.0200449497528368 0.0993498393183675 2.06260299150716 0.625 19.2 19 2 abnormal kidney epithelium morphology 0.0200449497528368 0.0993498393183675 2.06260299150716 0.625 19.2 19 2 accumulation of giant lysosomes in kidney/renal tubule cells 0.0200449497528368 0.0993498393183675 2.06260299150716 0.625 19.2 19 2 abnormal vertebral body development 0.0200449497528368 0.0993498393183675 2.06260299150716 0.625 19.2 19 2 ocular hypertension 0.0200449497528368 0.0993498393183675 2.06260299150716 0.625 19.2 19 2 abnormal ilium morphology 0.0200449497528368 0.0993498393183675 2.06260299150716 0.625 19.2 19 2 choroidal neovascularization 0.0200449497528368 0.0993498393183675 2.06260299150716 0.625 19.2 19 2 abnormal olfactory bulb mitral cell layer morphology 0.0200449497528368 0.0993498393183675 2.06260299150716 0.625 19.2 19 2 pleural effusion 0.0200449497528368 0.0993498393183675 2.06260299150716 0.625 19.2 19 2 abnormal hepatic vein morphology 0.0200449497528368 0.0993498393183675 2.06260299150716 0.625 19.2 19 2 anomalous pulmonary venous connection 0.0200449497528368 0.0993498393183675 2.06260299150716 0.625 19.2 19 2 impaired neuron differentiation 0.0200449497528368 0.0993498393183675 2.06260299150716 0.625 19.2 19 2 abnormal heart echocardiography feature 0.0200449497528368 0.0993498393183675 2.06260299150716 0.625 19.2 19 2 increased circulating lactate level 0.0200449497528368 0.0993498393183675 2.06260299150716 0.625 19.2 19 2 retropleural edema 0.0200449497528368 0.0993498393183675 2.06260299150716 0.625 19.2 19 2 abnormal umbilical vein topology 0.0200449497528368 0.0993498393183675 2.06260299150716 0.625 19.2 19 2 embryo cyst 0.0200449497528368 0.0993498393183675 2.06260299150716 0.625 19.2 19 2 abnormal myocardium layer morphology 2.0302159815559e-13 2.19572271918273e-11 2.04693765233116 0.620253164556962 19.2 19 2 left pulmonary isomerism 0.000170167968061245 0.00249965319549389 2.04295915349281 0.619047619047619 19.2 19 2 abnormal stapes morphology 0.000170167968061245 0.00249965319549389 2.04295915349281 0.619047619047619 19.2 19 2 short maxilla 1.76832754064053e-06 5.23656518731347e-05 2.03833707396002 0.617647058823529 19.2 19 2 increased foot pad pigmentation 0.00348263380927141 0.0270720362517583 2.03087063779167 0.615384615384615 19.2 19 2 anal atresia 0.00348263380927141 0.0270720362517583 2.03087063779167 0.615384615384615 19.2 19 2 increased circulating thyroxine level 0.00348263380927141 0.0270720362517583 2.03087063779167 0.615384615384615 19.2 19 2 absent hypoglossal nerve 0.00348263380927141 0.0270720362517583 2.03087063779167 0.615384615384615 19.2 19 2 absent spleen 0.000644192875517867 0.00750552589157234 2.01676736947367 0.611111111111111 19.2 19 2 small thoracic cage 0.000644192875517867 0.00750552589157234 2.01676736947367 0.611111111111111 19.2 19 2 embryonic lethality between implantation and placentation, complete penetrance 5.26720675635725e-08 2.47210883140352e-06 2.00879595694611 0.608695652173913 19.2 19 2 abnormal pulmonary artery morphology 0.000123140484071602 0.00190681804348329 2.00879595694611 0.608695652173913 19.2 19 2 abnormal corneal stroma morphology 0.000123140484071602 0.00190681804348329 2.00879595694611 0.608695652173913 19.2 19 2 abnormal middle ear ossicle morphology 4.75016486839512e-06 0.000125702501171626 2.0000998705524 0.606060606060606 19.2 19 2 atrioventricular septal defect 7.84659524896271e-09 4.48815155805538e-07 1.99255232387107 0.60377358490566 19.2 19 2 abnormal primitive streak morphology 8.8649987143061e-05 0.0014319275520673 1.98009887184688 0.6 19.2 19 2 abnormal incus morphology 0.000460138560889852 0.00566832431706991 1.98009887184688 0.6 19.2 19 2 absent incisors 0.00245469840045662 0.0214624332904599 1.98009887184688 0.6 19.2 19 2 macrocytosis 0.00245469840045662 0.0214624332904599 1.98009887184688 0.6 19.2 19 2 interdigital webbing 0.00245469840045662 0.0214624332904599 1.98009887184688 0.6 19.2 19 2 abnormal pericyte morphology 0.00245469840045662 0.0214624332904599 1.98009887184688 0.6 19.2 19 2 abnormal aorta wall morphology 0.00245469840045662 0.0214624332904599 1.98009887184688 0.6 19.2 19 2 increased cranium width 0.0137462026932242 0.0744149710541789 1.98009887184688 0.6 19.2 19 2 abnormal grooming behavior 0.0137462026932242 0.0744149710541789 1.98009887184688 0.6 19.2 19 2 abnormal pituitary secretion 0.0137462026932242 0.0744149710541789 1.98009887184688 0.6 19.2 19 2 alcohol preference 0.0137462026932242 0.0744149710541789 1.98009887184688 0.6 19.2 19 2 ketoaciduria 0.0137462026932242 0.0744149710541789 1.98009887184688 0.6 19.2 19 2 abnormal tibialis anterior morphology 0.0137462026932242 0.0744149710541789 1.98009887184688 0.6 19.2 19 2 abnormal pillar cell morphology 0.0137462026932242 0.0744149710541789 1.98009887184688 0.6 19.2 19 2 increased heart rate variability 0.0137462026932242 0.0744149710541789 1.98009887184688 0.6 19.2 19 2 abnormal placental transport 0.0137462026932242 0.0744149710541789 1.98009887184688 0.6 19.2 19 2 decreased cochlear inner hair cell number 0.0137462026932242 0.0744149710541789 1.98009887184688 0.6 19.2 19 2 abnormal gonadal fat pad morphology 0.0137462026932242 0.0744149710541789 1.98009887184688 0.6 19.2 19 2 osteosclerosis 0.0137462026932242 0.0744149710541789 1.98009887184688 0.6 19.2 19 2 vascular smooth muscle hyperplasia 0.0137462026932242 0.0744149710541789 1.98009887184688 0.6 19.2 19 2 increased circulating fructosamine level 0.0137462026932242 0.0744149710541789 1.98009887184688 0.6 19.2 19 2 thin ventricle myocardium compact layer 0.0137462026932242 0.0744149710541789 1.98009887184688 0.6 19.2 19 2 fusion of atlas and odontoid process 0.0137462026932242 0.0744149710541789 1.98009887184688 0.6 19.2 19 2 abnormal vertebral body morphology 1.25324950732336e-05 0.000288653532358043 1.9594728419318 0.59375 19.2 19 2 abnormal brain commissure morphology 6.3573711232e-05 0.00107577963734422 1.95565320676235 0.592592592592593 19.2 19 2 abnormal facial nerve morphology 0.000327368299575433 0.00425236890440673 1.95009737378859 0.590909090909091 19.2 19 2 aphakia 0.000327368299575433 0.00425236890440673 1.95009737378859 0.590909090909091 19.2 19 2 prolonged PR interval 0.000327368299575433 0.00425236890440673 1.95009737378859 0.590909090909091 19.2 19 2 abnormal occipital bone morphology 0.000327368299575433 0.00425236890440673 1.95009737378859 0.590909090909091 19.2 19 2 increased adenoma incidence 0.000327368299575433 0.00425236890440673 1.95009737378859 0.590909090909091 19.2 19 2 abnormal vagus nerve morphology 0.00172423782316343 0.0164042579255234 1.94127340377145 0.588235294117647 19.2 19 2 abnormal dorsal-ventral axis patterning 0.00172423782316343 0.0164042579255234 1.94127340377145 0.588235294117647 19.2 19 2 decreased growth hormone level 0.00172423782316343 0.0164042579255234 1.94127340377145 0.588235294117647 19.2 19 2 common atrium 0.00172423782316343 0.0164042579255234 1.94127340377145 0.588235294117647 19.2 19 2 atrial septal defect 2.62282561239759e-07 1.01941854856859e-05 1.93705324419803 0.58695652173913 19.2 19 2 lordosis 4.5456849467589e-05 0.000813481388853436 1.93457935755154 0.586206896551724 19.2 19 2 increased mortality induced by gamma-irradiation 4.5456849467589e-05 0.000813481388853436 1.93457935755154 0.586206896551724 19.2 19 2 blood in lymph vessels 4.5456849467589e-05 0.000813481388853436 1.93457935755154 0.586206896551724 19.2 19 2 palatal shelves fail to meet at midline 1.29796170520369e-06 4.06123237948952e-05 1.93180377741159 0.585365853658537 19.2 19 2 abnormal axon morphology 5.20798486039888e-15 8.63657489349482e-13 1.92509612540668 0.583333333333333 19.2 19 2 abnormal truncus arteriosus septation 0.000232268416353506 0.00326905173830299 1.92509612540668 0.583333333333333 19.2 19 2 impaired embryo implantation 0.0094286312526916 0.059077380959875 1.92509612540668 0.583333333333333 19.2 19 2 increased fear-related response 0.0094286312526916 0.059077380959875 1.92509612540668 0.583333333333333 19.2 19 2 decreased left ventricle systolic pressure 0.0094286312526916 0.059077380959875 1.92509612540668 0.583333333333333 19.2 19 2 abnormal rostral-caudal body axis extension 0.0094286312526916 0.059077380959875 1.92509612540668 0.583333333333333 19.2 19 2 pale placenta 0.0094286312526916 0.059077380959875 1.92509612540668 0.583333333333333 19.2 19 2 stria vascularis degeneration 0.0094286312526916 0.059077380959875 1.92509612540668 0.583333333333333 19.2 19 2 decreased red blood cell distribution width 0.0094286312526916 0.059077380959875 1.92509612540668 0.583333333333333 19.2 19 2 persistent right dorsal aorta 0.0094286312526916 0.059077380959875 1.92509612540668 0.583333333333333 19.2 19 2 prenatal growth retardation 0.0094286312526916 0.059077380959875 1.92509612540668 0.583333333333333 19.2 19 2 abnormal eyelid morphology 3.24291726346352e-05 0.000615782953653855 1.91622471469052 0.580645161290323 19.2 19 2 increased B cell derived lymphoma incidence 1.36110893691934e-07 5.83751462170149e-06 1.91409557611865 0.58 19.2 19 2 persistence of hyaloid vascular system 4.62605125791735e-06 0.000123734435527628 1.91062171844874 0.578947368421053 19.2 19 2 short vibrissae 0.00120889430950075 0.0126084888674344 1.91062171844874 0.578947368421053 19.2 19 2 decreased circulating glycerol level 0.000164476515280942 0.00247709981459606 1.90394122292969 0.576923076923077 19.2 19 2 dextrocardia 2.30942289226572e-05 0.000463281406815402 1.90009487702478 0.575757575757576 19.2 19 2 abnormal chondrocyte morphology 7.02152734576663e-08 3.20477968304486e-06 1.89453904405102 0.574074074074074 19.2 19 2 abnormal cell adhesion 7.02152734576663e-08 3.20477968304486e-06 1.89453904405102 0.574074074074074 19.2 19 2 short mandible 5.034100980022e-08 2.38520498815328e-06 1.88580844937798 0.571428571428571 19.2 19 2 abnormal interparietal bone morphology 0.00647705338815678 0.0441415624740822 1.88580844937798 0.571428571428571 19.2 19 2 midline facial cleft 0.00647705338815678 0.0441415624740822 1.88580844937798 0.571428571428571 19.2 19 2 abnormal blood flow velocity 0.00647705338815678 0.0441415624740822 1.88580844937798 0.571428571428571 19.2 19 2 irregularly shaped pupil 0.00647705338815678 0.0441415624740822 1.88580844937798 0.571428571428571 19.2 19 2 increased hemangioma incidence 0.00647705338815678 0.0441415624740822 1.88580844937798 0.571428571428571 19.2 19 2 split sternum 0.00647705338815678 0.0441415624740822 1.88580844937798 0.571428571428571 19.2 19 2 abnormal embryonic/fetal subventricular zone morphology 0.00084676601799466 0.00932004632637927 1.88580844937798 0.571428571428571 19.2 19 2 absent segment of posterior cerebral artery 0.00084676601799466 0.00932004632637927 1.88580844937798 0.571428571428571 19.2 19 2 abnormal embryonic epiblast morphology 1.6423478348003e-05 0.000363141354583621 1.88580844937798 0.571428571428571 19.2 19 2 double outlet right ventricle 5.96038933938319e-14 8.2076569105342e-12 1.88140235487008 0.570093457943925 19.2 19 2 omphalocele 1.68261036965053e-06 5.04276300542855e-05 1.87509362864287 0.568181818181818 19.2 19 2 delayed eyelid opening 8.21703773397329e-05 0.00133982221346687 1.87009337896649 0.566666666666667 19.2 19 2 abnormal cellular respiration 8.21703773397329e-05 0.00133982221346687 1.87009337896649 0.566666666666667 19.2 19 2 failure to gastrulate 1.19854809789212e-06 3.822292812188e-05 1.86531053144995 0.565217391304348 19.2 19 2 abnormal vertebral artery topology 0.000592864459730411 0.00698933812122937 1.86531053144995 0.565217391304348 19.2 19 2 vertebral transformation 8.53067174282031e-07 2.88708108302932e-05 1.85634269235645 0.5625 19.2 19 2 absent mandible 0.0044579705821824 0.0328568942908999 1.85634269235645 0.5625 19.2 19 2 disorganized retinal layers 0.0044579705821824 0.0328568942908999 1.85634269235645 0.5625 19.2 19 2 disorganized yolk sac vascular plexus 0.0044579705821824 0.0328568942908999 1.85634269235645 0.5625 19.2 19 2 loose skin 0.0044579705821824 0.0328568942908999 1.85634269235645 0.5625 19.2 19 2 kidney degeneration 0.0044579705821824 0.0328568942908999 1.85634269235645 0.5625 19.2 19 2 impaired somite development 0.0044579705821824 0.0328568942908999 1.85634269235645 0.5625 19.2 19 2 decreased midbrain size 0.0044579705821824 0.0328568942908999 1.85634269235645 0.5625 19.2 19 2 decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 0.00041505550807589 0.00525420140630421 1.84809228039042 0.56 19.2 19 2 enlarged liver sinusoidal spaces 4.09343377506905e-05 0.000754253075221056 1.84420973358287 0.558823529411765 19.2 19 2 abnormal trigeminal ganglion morphology 0.00029060502034212 0.00389692715957424 1.8334248813397 0.555555555555556 19.2 19 2 thick interventricular septum 0.00029060502034212 0.00389692715957424 1.8334248813397 0.555555555555556 19.2 19 2 abnormal neuromuscular synapse morphology 3.41501321170307e-09 2.15059376306617e-07 1.8334248813397 0.555555555555556 19.2 19 2 abnormal heart shape 0.00307429400772038 0.0247085826953294 1.8334248813397 0.555555555555556 19.2 19 2 cortical renal glomerulopathies 0.00307429400772038 0.0247085826953294 1.8334248813397 0.555555555555556 19.2 19 2 abnormal phrenic nerve morphology 0.00307429400772038 0.0247085826953294 1.8334248813397 0.555555555555556 19.2 19 2 eye inflammation 0.00307429400772038 0.0247085826953294 1.8334248813397 0.555555555555556 19.2 19 2 abnormal metacarpal bone morphology 0.00307429400772038 0.0247085826953294 1.8334248813397 0.555555555555556 19.2 19 2 decreased activity of thyroid 0.00307429400772038 0.0247085826953294 1.8334248813397 0.555555555555556 19.2 19 2 abnormal anterior eye segment morphology 0.00307429400772038 0.0247085826953294 1.8334248813397 0.555555555555556 19.2 19 2 abnormal pregnancy 0.00307429400772038 0.0247085826953294 1.8334248813397 0.555555555555556 19.2 19 2 decreased tumor latency 0.00307429400772038 0.0247085826953294 1.8334248813397 0.555555555555556 19.2 19 2 distorted hair follicle pattern 0.0365525850247492 0.156496652752261 1.8334248813397 0.555555555555556 19.2 19 2 synostosis 0.0365525850247492 0.156496652752261 1.8334248813397 0.555555555555556 19.2 19 2 deformed nails 0.0365525850247492 0.156496652752261 1.8334248813397 0.555555555555556 19.2 19 2 abnormal lens vesicle development 0.0365525850247492 0.156496652752261 1.8334248813397 0.555555555555556 19.2 19 2 abnormal ion homeostasis 0.0365525850247492 0.156496652752261 1.8334248813397 0.555555555555556 19.2 19 2 increased pheochromocytoma incidence 0.0365525850247492 0.156496652752261 1.8334248813397 0.555555555555556 19.2 19 2 absent posterior semicircular canal 0.0365525850247492 0.156496652752261 1.8334248813397 0.555555555555556 19.2 19 2 abnormal artery development 0.0365525850247492 0.156496652752261 1.8334248813397 0.555555555555556 19.2 19 2 abnormal ovary physiology 0.0365525850247492 0.156496652752261 1.8334248813397 0.555555555555556 19.2 19 2 abnormal bony labyrinth 0.0365525850247492 0.156496652752261 1.8334248813397 0.555555555555556 19.2 19 2 decreased thyroid-stimulating hormone level 0.0365525850247492 0.156496652752261 1.8334248813397 0.555555555555556 19.2 19 2 liver hyperplasia 0.0365525850247492 0.156496652752261 1.8334248813397 0.555555555555556 19.2 19 2 abnormal posterior eye segment morphology 0.0365525850247492 0.156496652752261 1.8334248813397 0.555555555555556 19.2 19 2 positive geotaxis 0.0365525850247492 0.156496652752261 1.8334248813397 0.555555555555556 19.2 19 2 abnormal retinal development 0.0365525850247492 0.156496652752261 1.8334248813397 0.555555555555556 19.2 19 2 abnormal cerebellar layer morphology 0.0365525850247492 0.156496652752261 1.8334248813397 0.555555555555556 19.2 19 2 abnormal ventricle myocardium morphology 0.0365525850247492 0.156496652752261 1.8334248813397 0.555555555555556 19.2 19 2 reduced AMPA-mediated synaptic currents 0.0365525850247492 0.156496652752261 1.8334248813397 0.555555555555556 19.2 19 2 symmetric azygos veins 0.0365525850247492 0.156496652752261 1.8334248813397 0.555555555555556 19.2 19 2 increased cardiac muscle glycogen level 0.0365525850247492 0.156496652752261 1.8334248813397 0.555555555555556 19.2 19 2 decreased fatty acid oxidation 0.0365525850247492 0.156496652752261 1.8334248813397 0.555555555555556 19.2 19 2 abnormal craniofacial morphology 2.13858531274306e-12 2.04605037132629e-10 1.82630478471314 0.553398058252427 19.2 19 2 absent long term depression 0.000203516677643167 0.00295188184045118 1.82078057181322 0.551724137931034 19.2 19 2 abnormal outer ear morphology 0.000203516677643167 0.00295188184045118 1.82078057181322 0.551724137931034 19.2 19 2 ventricular septal defect 9.83104839738938e-16 1.81146169544489e-13 1.81994381603573 0.551470588235294 19.2 19 2 abnormal pericardium morphology 0.00212404022446963 0.0193536632174659 1.8150906325263 0.55 19.2 19 2 abnormal hearing physiology 0.00212404022446963 0.0193536632174659 1.8150906325263 0.55 19.2 19 2 absent ductus venosus valve 0.00212404022446963 0.0193536632174659 1.8150906325263 0.55 19.2 19 2 abnormal cued conditioning behavior 1.04676153558536e-06 3.40224484417924e-05 1.81185517685335 0.549019607843137 19.2 19 2 small lung 1.04676153558536e-06 3.40224484417924e-05 1.81185517685335 0.549019607843137 19.2 19 2 lethality throughout fetal growth and development, incomplete penetrance 8.44358784623731e-20 2.47099114911945e-17 1.80679412887331 0.547486033519553 19.2 19 2 belly spot 9.99102787626875e-05 0.00158803078864016 1.80008988349716 0.545454545454545 19.2 19 2 intracerebral hemorrhage 0.00147004328009773 0.0144821095415569 1.80008988349716 0.545454545454545 19.2 19 2 abnormal temporal bone morphology 0.00147004328009773 0.0144821095415569 1.80008988349716 0.545454545454545 19.2 19 2 abnormal stomach epithelium morphology 0.0243498187987702 0.116818079579442 1.80008988349716 0.545454545454545 19.2 19 2 abnormal sebaceous gland morphology 0.0243498187987702 0.116818079579442 1.80008988349716 0.545454545454545 19.2 19 2 abnormal proximal-distal axis patterning 0.0243498187987702 0.116818079579442 1.80008988349716 0.545454545454545 19.2 19 2 abnormal fear/anxiety-related behavior 0.0243498187987702 0.116818079579442 1.80008988349716 0.545454545454545 19.2 19 2 fatigue 0.0243498187987702 0.116818079579442 1.80008988349716 0.545454545454545 19.2 19 2 pulmonary hypertension 0.0243498187987702 0.116818079579442 1.80008988349716 0.545454545454545 19.2 19 2 abnormal radial glial cell morphology 0.0243498187987702 0.116818079579442 1.80008988349716 0.545454545454545 19.2 19 2 abnormal coronal suture morphology 0.0243498187987702 0.116818079579442 1.80008988349716 0.545454545454545 19.2 19 2 pharyngeal arch hypoplasia 0.0243498187987702 0.116818079579442 1.80008988349716 0.545454545454545 19.2 19 2 abnormal crista ampullaris neuroepithelium morphology 0.0243498187987702 0.116818079579442 1.80008988349716 0.545454545454545 19.2 19 2 abnormal Bruch membrane morphology 0.0243498187987702 0.116818079579442 1.80008988349716 0.545454545454545 19.2 19 2 increased glycogen level 0.0243498187987702 0.116818079579442 1.80008988349716 0.545454545454545 19.2 19 2 abnormal superovulation 0.0243498187987702 0.116818079579442 1.80008988349716 0.545454545454545 19.2 19 2 abnormal palatal shelf elevation 0.0243498187987702 0.116818079579442 1.80008988349716 0.545454545454545 19.2 19 2 decreased core body temperature 0.0243498187987702 0.116818079579442 1.80008988349716 0.545454545454545 19.2 19 2 hypolactation 0.0243498187987702 0.116818079579442 1.80008988349716 0.545454545454545 19.2 19 2 thin hypoglossal nerve 0.0243498187987702 0.116818079579442 1.80008988349716 0.545454545454545 19.2 19 2 abnormal locomotor behavior 1.13664022628361e-10 8.97584940596978e-09 1.79356781870188 0.543478260869565 19.2 19 2 decreased bone volume 7.00409832913816e-05 0.0011653976316877 1.79151802690908 0.542857142857143 19.2 19 2 prolonged QT interval 0.00101902342008494 0.0107864713083459 1.78758925930621 0.541666666666667 19.2 19 2 abnormal lung development 7.50944822989929e-10 5.41442100634043e-08 1.78597153146973 0.541176470588235 19.2 19 2 abnormal breathing pattern 4.91201460398522e-05 0.000869653831132615 1.78387285751971 0.540540540540541 19.2 19 2 decreased width of hypertrophic chondrocyte zone 4.91201460398522e-05 0.000869653831132615 1.78387285751971 0.540540540540541 19.2 19 2 no spontaneous movement 0.00070739766633666 0.00801663642374689 1.77701180806771 0.538461538461538 19.2 19 2 heart inflammation 0.00070739766633666 0.00801663642374689 1.77701180806771 0.538461538461538 19.2 19 2 abnormal Mullerian duct morphology 0.00070739766633666 0.00801663642374689 1.77701180806771 0.538461538461538 19.2 19 2 short premaxilla 0.0163656282700151 0.0868006403446963 1.77701180806771 0.538461538461538 19.2 19 2 absent common myeloid progenitor cells 0.0163656282700151 0.0868006403446963 1.77701180806771 0.538461538461538 19.2 19 2 increased pituitary adenoma incidence 0.0163656282700151 0.0868006403446963 1.77701180806771 0.538461538461538 19.2 19 2 absent lateral semicircular canal 0.0163656282700151 0.0868006403446963 1.77701180806771 0.538461538461538 19.2 19 2 axonal dystrophy 0.0163656282700151 0.0868006403446963 1.77701180806771 0.538461538461538 19.2 19 2 decreased endocochlear potential 0.0163656282700151 0.0868006403446963 1.77701180806771 0.538461538461538 19.2 19 2 orthokeratosis 0.0163656282700151 0.0868006403446963 1.77701180806771 0.538461538461538 19.2 19 2 abnormal cochlea morphology 1.24461345055168e-06 3.91895690917379e-05 1.77231071862838 0.537037037037037 19.2 19 2 abnormal apoptosis 1.24461345055168e-06 3.91895690917379e-05 1.77231071862838 0.537037037037037 19.2 19 2 abnormal developmental patterning 2.49215032531917e-09 1.65312638246171e-07 1.77082012929395 0.536585365853659 19.2 19 2 short humerus 2.41862610801001e-05 0.000479389039336646 1.77082012929395 0.536585365853659 19.2 19 2 increased bone resorption 0.000491713210889025 0.00588046448118485 1.76794542129185 0.535714285714286 19.2 19 2 abnormal brainstem morphology 0.000491713210889025 0.00588046448118485 1.76794542129185 0.535714285714286 19.2 19 2 abnormal double-strand DNA break repair 1.69810315224687e-05 0.000371641667953138 1.76520442063869 0.534883720930233 19.2 19 2 abnormal embryonic neuroepithelium morphology 6.19223800641055e-07 2.18484993488599e-05 1.76388117894406 0.53448275862069 19.2 19 2 trabecula carnea hypoplasia 1.19265155243424e-05 0.000277263620250483 1.76008788608611 0.533333333333333 19.2 19 2 lethality at weaning, complete penetrance 1.19265155243424e-05 0.000277263620250483 1.76008788608611 0.533333333333333 19.2 19 2 abnormal lactation 0.000342198163704234 0.00437644181087034 1.76008788608611 0.533333333333333 19.2 19 2 no suckling reflex 0.011074030516957 0.0680164220022973 1.76008788608611 0.533333333333333 19.2 19 2 placental labyrinth hypoplasia 0.011074030516957 0.0680164220022973 1.76008788608611 0.533333333333333 19.2 19 2 arthritis 0.011074030516957 0.0680164220022973 1.76008788608611 0.533333333333333 19.2 19 2 delayed intramembranous bone ossification 0.011074030516957 0.0680164220022973 1.76008788608611 0.533333333333333 19.2 19 2 abnormal olfactory nerve morphology 0.011074030516957 0.0680164220022973 1.76008788608611 0.533333333333333 19.2 19 2 bicuspid aortic valve 0.011074030516957 0.0680164220022973 1.76008788608611 0.533333333333333 19.2 19 2 abnormal coronary vessel morphology 0.011074030516957 0.0680164220022973 1.76008788608611 0.533333333333333 19.2 19 2 abnormal eye morphology 1.84631186157169e-14 2.78345500343004e-12 1.75692226039171 0.532374100719424 19.2 19 2 increased respiratory quotient 8.37937520658087e-06 0.000205356609126797 1.75540680128269 0.531914893617021 19.2 19 2 abnormal skeleton development 5.8113954506533e-09 3.48333642975906e-07 1.75193933105793 0.530864197530864 19.2 19 2 abnormal embryonic tissue morphology 4.67915843336682e-15 8.02717696758618e-13 1.75110784585098 0.530612244897959 19.2 19 2 abnormal cranium morphology 8.49039852867055e-14 1.03023738244234e-11 1.74859477488965 0.529850746268657 19.2 19 2 abnormal spleen red pulp morphology 0.000166258212401183 0.00247709981459606 1.7471460633943 0.529411764705882 19.2 19 2 abnormal bone marrow cavity morphology 0.00753341993607873 0.0498387821569038 1.7471460633943 0.529411764705882 19.2 19 2 abnormal interatrial septum morphology 0.00753341993607873 0.0498387821569038 1.7471460633943 0.529411764705882 19.2 19 2 absence seizures 0.00753341993607873 0.0498387821569038 1.7471460633943 0.529411764705882 19.2 19 2 coloboma 0.00753341993607873 0.0498387821569038 1.7471460633943 0.529411764705882 19.2 19 2 enhanced behavioral response to cocaine 0.00753341993607873 0.0498387821569038 1.7471460633943 0.529411764705882 19.2 19 2 increased trabecular bone mass 0.00753341993607873 0.0498387821569038 1.7471460633943 0.529411764705882 19.2 19 2 enlarged kidney 2.91163601064334e-06 8.13785907469137e-05 1.74348328338719 0.528301886792453 19.2 19 2 short snout 2.81254359108598e-11 2.29383678125455e-09 1.74175363727271 0.527777777777778 19.2 19 2 short radius 0.000116050018604443 0.00180987097980283 1.74175363727271 0.527777777777778 19.2 19 2 abnormal contextual conditioning behavior 2.04818488275121e-06 5.92425569284143e-05 1.74008688738059 0.527272727272727 19.2 19 2 abnormal cell morphology 9.98615090698174e-12 8.5657070279714e-10 1.7369288349534 0.526315789473684 19.2 19 2 decreased birth body size 9.98615090698174e-12 8.5657070279714e-10 1.7369288349534 0.526315789473684 19.2 19 2 abnormal axial skeleton morphology 2.68964119161581e-08 1.31185930669497e-06 1.7369288349534 0.526315789473684 19.2 19 2 decreased brain weight 1.4411854376208e-06 4.42586268652066e-05 1.7369288349534 0.526315789473684 19.2 19 2 irregular coat pigmentation 0.00514696033907551 0.0367904133432481 1.7369288349534 0.526315789473684 19.2 19 2 enlarged adrenal glands 0.00514696033907551 0.0367904133432481 1.7369288349534 0.526315789473684 19.2 19 2 abnormal neural crest cell migration 0.00514696033907551 0.0367904133432481 1.7369288349534 0.526315789473684 19.2 19 2 abnormal optic vesicle formation 0.00514696033907551 0.0367904133432481 1.7369288349534 0.526315789473684 19.2 19 2 increased circulating VLDL cholesterol level 0.00514696033907551 0.0367904133432481 1.7369288349534 0.526315789473684 19.2 19 2 decreased susceptibility to weight gain 0.00514696033907551 0.0367904133432481 1.7369288349534 0.526315789473684 19.2 19 2 right-sided stomach 0.00514696033907551 0.0367904133432481 1.7369288349534 0.526315789473684 19.2 19 2 increased embryonic tissue cell apoptosis 1.89914173118755e-08 9.64105113536537e-07 1.73470200311372 0.525641025641026 19.2 19 2 abnormal scapula morphology 0.00352904185159207 0.0272623962914139 1.72865774526315 0.523809523809524 19.2 19 2 abnormal erythrocyte physiology 0.00352904185159207 0.0272623962914139 1.72865774526315 0.523809523809524 19.2 19 2 abnormal clavicle morphology 0.00352904185159207 0.0272623962914139 1.72865774526315 0.523809523809524 19.2 19 2 complete atrioventricular septal defect 0.00352904185159207 0.0272623962914139 1.72865774526315 0.523809523809524 19.2 19 2 abnormal allantois morphology 1.94464241418623e-05 0.00040747074601237 1.7218251059538 0.521739130434783 19.2 19 2 hypotension 0.00242696562958936 0.0214080744808636 1.7218251059538 0.521739130434783 19.2 19 2 abnormal cochlear ganglion morphology 0.00242696562958936 0.0214080744808636 1.7218251059538 0.521739130434783 19.2 19 2 dilated heart 0.00242696562958936 0.0214080744808636 1.7218251059538 0.521739130434783 19.2 19 2 abnormal basicranium morphology 0.00242696562958936 0.0214080744808636 1.7218251059538 0.521739130434783 19.2 19 2 abnormal hematopoietic stem cell physiology 0.00242696562958936 0.0214080744808636 1.7218251059538 0.521739130434783 19.2 19 2 abnormal interventricular septum morphology 9.55797509221516e-06 0.000230358475375717 1.71608568893396 0.52 19.2 19 2 abnormal thyroid gland morphology 0.00167332199142809 0.0161871227200522 1.71608568893396 0.52 19.2 19 2 spontaneous skin ulceration 0.00167332199142809 0.0161871227200522 1.71608568893396 0.52 19.2 19 2 eyelids open at birth 6.70582202054093e-06 0.000169347535797924 1.71354710063672 0.519230769230769 19.2 19 2 abnormal placenta vasculature 6.70582202054093e-06 0.000169347535797924 1.71354710063672 0.519230769230769 19.2 19 2 abnormal mandible morphology 4.70689107535745e-06 0.000125223439036916 1.71119655591705 0.518518518518518 19.2 19 2 abnormal atrioventricular cushion morphology 0.00115625128510002 0.0120847692087659 1.71119655591705 0.518518518518518 19.2 19 2 abnormal trigeminal nerve morphology 0.00115625128510002 0.0120847692087659 1.71119655591705 0.518518518518518 19.2 19 2 decreased circulating fructosamine level 0.00115625128510002 0.0120847692087659 1.71119655591705 0.518518518518518 19.2 19 2 abnormal middle ear morphology 0.0008004952107953 0.00898975998579372 1.70698178607489 0.517241379310345 19.2 19 2 decreased trophoblast giant cell number 0.0008004952107953 0.00898975998579372 1.70698178607489 0.517241379310345 19.2 19 2 abnormal muscle physiology 5.35233843481192e-09 3.28739305101102e-07 1.70570314803289 0.51685393258427 19.2 19 2 muscular ventricular septal defect 1.63167105528647e-06 4.91973545457587e-05 1.70508513964592 0.516666666666667 19.2 19 2 abnormal object recognition memory 0.000555134432589288 0.00659139332251004 1.70331085750269 0.516129032258065 19.2 19 2 small cranium 0.000555134432589288 0.00659139332251004 1.70331085750269 0.516129032258065 19.2 19 2 decreased caudal vertebrae number 8.06619052921284e-07 2.76753778502303e-05 1.70164746799341 0.515625 19.2 19 2 increased cardiomyocyte apoptosis 0.00038555532690068 0.00490572314918384 1.70008488996954 0.515151515151515 19.2 19 2 prenatal lethality, complete penetrance 1.35599444640571e-24 6.13279306442583e-22 1.69756677862172 0.514388489208633 19.2 19 2 embryonic lethality between somite formation and embryo turning, complete penetrance 2.80996258393823e-07 1.07535106577636e-05 1.69722760444018 0.514285714285714 19.2 19 2 decreased glycogen level 0.000268135278517444 0.0036428111973572 1.69722760444018 0.514285714285714 19.2 19 2 decreased circulating thyroxine level 0.000268135278517444 0.0036428111973572 1.69722760444018 0.514285714285714 19.2 19 2 abnormal angiogenesis 1.39301545794421e-07 5.87309483328173e-06 1.69467921464372 0.513513513513513 19.2 19 2 kidney cysts 1.39301545794421e-07 5.87309483328173e-06 1.69467921464372 0.513513513513513 19.2 19 2 abnormal bone mineralization 2.05202969543045e-11 1.70147462246109e-09 1.69099352692157 0.512396694214876 19.2 19 2 abnormal mammary gland development 9.07970853874336e-05 0.00145714677355639 1.69032830523514 0.51219512195122 19.2 19 2 thick ventricular wall 9.07970853874336e-05 0.00145714677355639 1.69032830523514 0.51219512195122 19.2 19 2 perinatal lethality, complete penetrance 6.99741773796812e-19 1.74060766231957e-16 1.68881672168474 0.511737089201878 19.2 19 2 delayed endochondral bone ossification 6.3406667958084e-05 0.00107577963734422 1.68845640235005 0.511627906976744 19.2 19 2 cleft palate 3.61879829107982e-12 3.27336754511311e-10 1.68787053961502 0.511450381679389 19.2 19 2 absent kidney 2.16930110736407e-05 0.000436934129924544 1.68375754408748 0.510204081632653 19.2 19 2 failure of chorioallantoic fusion 1.51923804153497e-05 0.000338933150521815 1.68243694993525 0.509803921568627 19.2 19 2 decreased circulating total protein level 7.46406786768978e-06 0.000184112408197361 1.68008389126402 0.509090909090909 19.2 19 2 reduced long term potentiation 1.83599149739511e-10 1.40523964608318e-08 1.67954815022726 0.508928571428571 19.2 19 2 abnormal facial morphology 5.23581122273431e-06 0.000135667504339079 1.67903120712162 0.508771929824561 19.2 19 2 corneal opacity 4.42586791950747e-07 1.63101428885553e-05 1.67332299029313 0.507042253521127 19.2 19 2 kyphosis 2.50040340830288e-13 2.64670360772486e-11 1.67208349178181 0.506666666666667 19.2 19 2 delayed bone ossification 2.19135400887044e-07 8.5842410977405e-06 1.67208349178181 0.506666666666667 19.2 19 2 anophthalmia 1.88562623209974e-08 9.64105113536537e-07 1.66862264481478 0.50561797752809 19.2 19 2 cyanosis 1.72172988688794e-16 3.56900257802812e-14 1.66727075146829 0.505208333333333 19.2 19 2 abnormal brain morphology 6.86445114003293e-14 8.75657549273431e-12 1.66033135216974 0.503105590062112 19.2 19 2 abnormal maxilla morphology 1.65849854478195e-05 0.000365089834526115 1.65008239320573 0.5 19.2 19 2 kinked neural tube 2.36789388101584e-05 0.00047310329550417 1.65008239320573 0.5 19.2 19 2 decreased circulating alkaline phosphatase level 3.38280470550665e-05 0.000639903171478919 1.65008239320573 0.5 19.2 19 2 lymphoid hyperplasia 0.001820789359311 0.0170271185386696 1.65008239320573 0.5 19.2 19 2 absent corpus callosum 0.001820789359311 0.0170271185386696 1.65008239320573 0.5 19.2 19 2 increased triglyceride level 0.001820789359311 0.0170271185386696 1.65008239320573 0.5 19.2 19 2 abnormal renal tubule epithelium morphology 0.001820789359311 0.0170271185386696 1.65008239320573 0.5 19.2 19 2 prolonged QRS complex duration 0.001820789359311 0.0170271185386696 1.65008239320573 0.5 19.2 19 2 subcutaneous edema 0.001820789359311 0.0170271185386696 1.65008239320573 0.5 19.2 19 2 increased susceptibility to otitis media 0.00263924631651951 0.0228750007398686 1.65008239320573 0.5 19.2 19 2 abnormal mitral valve morphology 0.0119925458644371 0.070042166073141 1.65008239320573 0.5 19.2 19 2 increased circulating renin level 0.0119925458644371 0.070042166073141 1.65008239320573 0.5 19.2 19 2 absent ureter 0.0119925458644371 0.070042166073141 1.65008239320573 0.5 19.2 19 2 darkened coat color 0.0119925458644371 0.070042166073141 1.65008239320573 0.5 19.2 19 2 jerky movement 0.0119925458644371 0.070042166073141 1.65008239320573 0.5 19.2 19 2 primary atelectasis 0.0119925458644371 0.070042166073141 1.65008239320573 0.5 19.2 19 2 increased effector memory CD8-positive, alpha-beta T cell number 0.0119925458644371 0.070042166073141 1.65008239320573 0.5 19.2 19 2 abnormal hypoglossal nerve topology 0.0119925458644371 0.070042166073141 1.65008239320573 0.5 19.2 19 2 abnormal pinna reflex 0.0262542031518734 0.12284445676224 1.65008239320573 0.5 19.2 19 2 abnormal kidney medulla morphology 0.0262542031518734 0.12284445676224 1.65008239320573 0.5 19.2 19 2 intestinal obstruction 0.0262542031518734 0.12284445676224 1.65008239320573 0.5 19.2 19 2 vascular smooth muscle hypoplasia 0.0262542031518734 0.12284445676224 1.65008239320573 0.5 19.2 19 2 abnormal viscerocranium morphology 0.0262542031518734 0.12284445676224 1.65008239320573 0.5 19.2 19 2 decreased cornea thickness 0.0262542031518734 0.12284445676224 1.65008239320573 0.5 19.2 19 2 sternebra fusion 0.0262542031518734 0.12284445676224 1.65008239320573 0.5 19.2 19 2 abnormal renal tubule epithelial cell primary cilium morphology 0.0262542031518734 0.12284445676224 1.65008239320573 0.5 19.2 19 2 testis degeneration 0.0262542031518734 0.12284445676224 1.65008239320573 0.5 19.2 19 2 abnormal vitelline vein topology 0.0262542031518734 0.12284445676224 1.65008239320573 0.5 19.2 19 2 abnormal myelin sheath morphology 6.91833635945818e-05 0.00115499071772834 1.65008239320573 0.5 19.2 19 2 abnormal amino acid level 9.90525020903735e-05 0.00157944294198592 1.65008239320573 0.5 19.2 19 2 abnormal pancreas morphology 0.000141940154016401 0.00217277620378952 1.65008239320573 0.5 19.2 19 2 abnormal nervous system development 0.000604852441400176 0.00709703041501386 1.65008239320573 0.5 19.2 19 2 kidney cortex cysts 0.000871864017621713 0.00953301865421544 1.65008239320573 0.5 19.2 19 2 pancreatic islet hyperplasia 0.000871864017621713 0.00953301865421544 1.65008239320573 0.5 19.2 19 2 enhanced paired-pulse facilitation 0.00125879225788637 0.0128593254270732 1.65008239320573 0.5 19.2 19 2 abnormal optic cup morphology 0.00125879225788637 0.0128593254270732 1.65008239320573 0.5 19.2 19 2 abnormal malleus morphology 0.00383490783909376 0.0292617584348029 1.65008239320573 0.5 19.2 19 2 abnormal body weight 0.00383490783909376 0.0292617584348029 1.65008239320573 0.5 19.2 19 2 abnormal tumor morphology 0.00383490783909376 0.0292617584348029 1.65008239320573 0.5 19.2 19 2 increased hemangiosarcoma incidence 0.00383490783909376 0.0292617584348029 1.65008239320573 0.5 19.2 19 2 abnormal tail movements 0.00558804042308643 0.0394921659744158 1.65008239320573 0.5 19.2 19 2 abnormal female reproductive system physiology 0.00558804042308643 0.0394921659744158 1.65008239320573 0.5 19.2 19 2 abnormal limb posture 0.00558804042308643 0.0394921659744158 1.65008239320573 0.5 19.2 19 2 cleft upper lip 0.00558804042308643 0.0394921659744158 1.65008239320573 0.5 19.2 19 2 abnormal mesenteric lymph node morphology 0.00558804042308643 0.0394921659744158 1.65008239320573 0.5 19.2 19 2 rough coat 0.00558804042308643 0.0394921659744158 1.65008239320573 0.5 19.2 19 2 increased mammary gland tumor incidence 0.00558804042308643 0.0394921659744158 1.65008239320573 0.5 19.2 19 2 abnormal hyoid bone morphology 0.00816988045368143 0.0536215768562864 1.65008239320573 0.5 19.2 19 2 spleen atrophy 0.00816988045368143 0.0536215768562864 1.65008239320573 0.5 19.2 19 2 abnormal physiological neovascularization 0.00816988045368143 0.0536215768562864 1.65008239320573 0.5 19.2 19 2 abnormal pituitary gland morphology 0.0176900904517315 0.0924455882325256 1.65008239320573 0.5 19.2 19 2 white spotting 0.0176900904517315 0.0924455882325256 1.65008239320573 0.5 19.2 19 2 increased intestinal adenocarcinoma incidence 0.0176900904517315 0.0924455882325256 1.65008239320573 0.5 19.2 19 2 decreased aggression towards mice 0.0176900904517315 0.0924455882325256 1.65008239320573 0.5 19.2 19 2 bowed radius 0.0176900904517315 0.0924455882325256 1.65008239320573 0.5 19.2 19 2 blepharitis 0.0176900904517315 0.0924455882325256 1.65008239320573 0.5 19.2 19 2 abnormal thoracic cage shape 0.0176900904517315 0.0924455882325256 1.65008239320573 0.5 19.2 19 2 decreased fibroblast apoptosis 0.0176900904517315 0.0924455882325256 1.65008239320573 0.5 19.2 19 2 abnormal supraoccipital bone morphology 0.0392710063448488 0.160378204330247 1.65008239320573 0.5 19.2 19 2 amyloidosis 0.0392710063448488 0.160378204330247 1.65008239320573 0.5 19.2 19 2 abnormal superior cervical ganglion morphology 0.0392710063448488 0.160378204330247 1.65008239320573 0.5 19.2 19 2 abnormal mating frequency 0.0392710063448488 0.160378204330247 1.65008239320573 0.5 19.2 19 2 abnormal pilomotor reflex 0.0392710063448488 0.160378204330247 1.65008239320573 0.5 19.2 19 2 interstitial pneumonia 0.0392710063448488 0.160378204330247 1.65008239320573 0.5 19.2 19 2 increased growth rate 0.0392710063448488 0.160378204330247 1.65008239320573 0.5 19.2 19 2 abnormal corticospinal tract morphology 0.0392710063448488 0.160378204330247 1.65008239320573 0.5 19.2 19 2 small thyroid gland 0.0392710063448488 0.160378204330247 1.65008239320573 0.5 19.2 19 2 abnormal alisphenoid bone morphology 0.0392710063448488 0.160378204330247 1.65008239320573 0.5 19.2 19 2 loss of dopaminergic neurons 0.0392710063448488 0.160378204330247 1.65008239320573 0.5 19.2 19 2 abnormal vascular endothelial cell development 0.0392710063448488 0.160378204330247 1.65008239320573 0.5 19.2 19 2 vestibular saccular macula degeneration 0.0392710063448488 0.160378204330247 1.65008239320573 0.5 19.2 19 2 decreased cochlear nerve compound action potential 0.0392710063448488 0.160378204330247 1.65008239320573 0.5 19.2 19 2 hematuria 0.0392710063448488 0.160378204330247 1.65008239320573 0.5 19.2 19 2 abnormal fatty acid level 0.0392710063448488 0.160378204330247 1.65008239320573 0.5 19.2 19 2 reduced cerebellar foliation 0.0392710063448488 0.160378204330247 1.65008239320573 0.5 19.2 19 2 decreased mammary gland epithelial cell proliferation 0.0392710063448488 0.160378204330247 1.65008239320573 0.5 19.2 19 2 increased skeletal muscle glycogen level 0.0392710063448488 0.160378204330247 1.65008239320573 0.5 19.2 19 2 abnormal pulmonary valve cusp morphology 0.0392710063448488 0.160378204330247 1.65008239320573 0.5 19.2 19 2 abnormal lateral semicircular canal morphology 0.0593589673562742 0.196089550197519 1.65008239320573 0.5 19.2 19 2 abnormal otic capsule morphology 0.0593589673562742 0.196089550197519 1.65008239320573 0.5 19.2 19 2 retarded hair growth 0.0593589673562742 0.196089550197519 1.65008239320573 0.5 19.2 19 2 kidney hemorrhage 0.0593589673562742 0.196089550197519 1.65008239320573 0.5 19.2 19 2 enlarged testis 0.0593589673562742 0.196089550197519 1.65008239320573 0.5 19.2 19 2 rhinitis 0.0593589673562742 0.196089550197519 1.65008239320573 0.5 19.2 19 2 decreased incidence of induced tumors 0.0593589673562742 0.196089550197519 1.65008239320573 0.5 19.2 19 2 abnormal neuron specification 0.0593589673562742 0.196089550197519 1.65008239320573 0.5 19.2 19 2 primary sex reversal 0.0593589673562742 0.196089550197519 1.65008239320573 0.5 19.2 19 2 delayed dark adaptation 0.0593589673562742 0.196089550197519 1.65008239320573 0.5 19.2 19 2 abnormal scala media morphology 0.0593589673562742 0.196089550197519 1.65008239320573 0.5 19.2 19 2 absent CD4-positive, alpha beta T cells 0.0593589673562742 0.196089550197519 1.65008239320573 0.5 19.2 19 2 increased atrioventricular cushion size 0.0593589673562742 0.196089550197519 1.65008239320573 0.5 19.2 19 2 abnormal reproductive system development 0.0593589673562742 0.196089550197519 1.65008239320573 0.5 19.2 19 2 abnormal utricular macula morphology 0.0593589673562742 0.196089550197519 1.65008239320573 0.5 19.2 19 2 abnormal corneal endothelium morphology 0.0593589673562742 0.196089550197519 1.65008239320573 0.5 19.2 19 2 increased susceptibility to atherosclerosis 0.0593589673562742 0.196089550197519 1.65008239320573 0.5 19.2 19 2 tachypnea 0.0593589673562742 0.196089550197519 1.65008239320573 0.5 19.2 19 2 increased platelet aggregation 0.0593589673562742 0.196089550197519 1.65008239320573 0.5 19.2 19 2 abnormal spinal cord dorsal column morphology 0.0593589673562742 0.196089550197519 1.65008239320573 0.5 19.2 19 2 abnormal cerebellar granule cell migration 0.0593589673562742 0.196089550197519 1.65008239320573 0.5 19.2 19 2 abnormal left subclavian artery morphology 0.0593589673562742 0.196089550197519 1.65008239320573 0.5 19.2 19 2 abnormal inferior vena cava valve morphology 0.0593589673562742 0.196089550197519 1.65008239320573 0.5 19.2 19 2 thick aortic valve 0.0593589673562742 0.196089550197519 1.65008239320573 0.5 19.2 19 2 hemorrhage 6.1778784225261e-19 1.61762869221407e-16 1.6430607660006 0.497872340425532 19.2 19 2 embryonic lethality before implantation, complete penetrance 1.19519737004365e-10 9.29079205619865e-09 1.63688173406008 0.496 19.2 19 2 decreased circulating serum albumin level 1.10760459684941e-08 5.86205624396365e-07 1.63341489428446 0.494949494949495 19.2 19 2 small spleen 4.48198562626827e-08 2.14402677795045e-06 1.63194961965402 0.494505494505495 19.2 19 2 abnormal neural tube closure 1.81891604552447e-07 7.2392858611874e-06 1.63020188244421 0.493975903614458 19.2 19 2 abnormal limb morphology 7.40839701341336e-07 2.57739686305814e-05 1.62808129462965 0.493333333333333 19.2 19 2 decreased percent body fat/body weight 1.05315719799719e-06 3.40224484417924e-05 1.62747852480565 0.493150684931507 19.2 19 2 abnormal sternum morphology 2.13026067331877e-06 6.12603864148027e-05 1.62616815562304 0.492753623188406 19.2 19 2 decreased susceptibility to hepatic steatosis 6.14445451768404e-06 0.000156762365258862 1.62389060918659 0.492063492063492 19.2 19 2 respiratory distress 9.43921522716791e-14 1.11809751798001e-11 1.62146824765881 0.491329479768786 19.2 19 2 perinatal lethality, incomplete penetrance 1.75135090141897e-17 3.7882481454606e-15 1.62087739509589 0.491150442477876 19.2 19 2 abnormal head morphology 2.53801559715162e-05 0.000501056650628147 1.62008089514744 0.490909090909091 19.2 19 2 abnormal cervical vertebrae morphology 5.17469572855628e-05 0.00090968590987871 1.61772783647621 0.490196078431373 19.2 19 2 abnormal gluconeogenesis 5.17469572855628e-05 0.00090968590987871 1.61772783647621 0.490196078431373 19.2 19 2 ataxia 1.11806068060065e-15 1.9865542449958e-13 1.61740749433037 0.49009900990099 19.2 19 2 abnormal long bone hypertrophic chondrocyte zone 7.39592976433534e-05 0.00122241696270991 1.61640724232398 0.489795918367347 19.2 19 2 increased T cell derived lymphoma incidence 7.39592976433534e-05 0.00122241696270991 1.61640724232398 0.489795918367347 19.2 19 2 lethality throughout fetal growth and development, complete penetrance 8.9300257696828e-15 1.38833994388037e-12 1.61534381650666 0.489473684210526 19.2 19 2 cardiomyopathy 0.000151410214302866 0.00231063133790417 1.61341389557894 0.488888888888889 19.2 19 2 abnormal organ of Corti morphology 0.000216903936162978 0.00307435066213908 1.61170838406141 0.488372093023256 19.2 19 2 abnormal left-right axis patterning 0.000216903936162978 0.00307435066213908 1.61170838406141 0.488372093023256 19.2 19 2 abnormal axon guidance 0.000216903936162978 0.00307435066213908 1.61170838406141 0.488372093023256 19.2 19 2 decreased oxygen consumption 0.000216903936162978 0.00307435066213908 1.61170838406141 0.488372093023256 19.2 19 2 short ulna 0.000311013198534633 0.00413714080938449 1.60983648117632 0.48780487804878 19.2 19 2 abnormal iris morphology 0.000446405125141898 0.00556607894130562 1.60777258825174 0.487179487179487 19.2 19 2 hydroencephaly 2.21384763645512e-09 1.48836378261678e-07 1.60703676555688 0.48695652173913 19.2 19 2 abnormal embryo size 3.13473151371529e-09 1.99939606163251e-07 1.60627489604098 0.486725663716814 19.2 19 2 preweaning lethality, incomplete penetrance 1.6736140792049e-29 8.32623004404439e-27 1.60570364913418 0.486552567237164 19.2 19 2 pale liver 1.59286504683084e-06 4.83201439511185e-05 1.60548557176774 0.486486486486487 19.2 19 2 decreased triglyceride level 0.000922863095233864 0.00993775735668501 1.60293718197128 0.485714285714286 19.2 19 2 enlarged pericardium 0.00132956631477092 0.0133628129615865 1.60007989644192 0.484848484848485 19.2 19 2 abnormal ovarian folliculogenesis 0.00132956631477092 0.0133628129615865 1.60007989644192 0.484848484848485 19.2 19 2 head tossing 0.00132956631477092 0.0133628129615865 1.60007989644192 0.484848484848485 19.2 19 2 prenatal lethality 1.3198014831673e-05 0.000302581215610936 1.59685392890877 0.483870967741935 19.2 19 2 abnormal cranial ganglia morphology 0.00191847146910237 0.0177405121910488 1.59685392890877 0.483870967741935 19.2 19 2 decreased thymus weight 0.00191847146910237 0.0177405121910488 1.59685392890877 0.483870967741935 19.2 19 2 abnormal podocyte morphology 0.00191847146910237 0.0177405121910488 1.59685392890877 0.483870967741935 19.2 19 2 prenatal lethality, incomplete penetrance 7.75392750295761e-22 3.21464911060118e-19 1.59580336711344 0.483552631578947 19.2 19 2 abnormal eating behavior 1.87984762634997e-05 0.000401383774295756 1.59507964676554 0.483333333333333 19.2 19 2 absent mesoderm 1.87984762634997e-05 0.000401383774295756 1.59507964676554 0.483333333333333 19.2 19 2 abnormal incisor morphology 1.87984762634997e-05 0.000401383774295756 1.59507964676554 0.483333333333333 19.2 19 2 abnormal spinal nerve morphology 0.00277306389792565 0.0236433017475975 1.59318300033657 0.482758620689655 19.2 19 2 abnormal embryonic erythropoiesis 0.00277306389792565 0.0236433017475975 1.59318300033657 0.482758620689655 19.2 19 2 polychromatophilia 0.00277306389792565 0.0236433017475975 1.59318300033657 0.482758620689655 19.2 19 2 edema 6.39043778179274e-13 6.35848559288378e-11 1.59252137948925 0.482558139534884 19.2 19 2 abnormal eye development 3.81886137001659e-05 0.000711566865761518 1.59115087916267 0.482142857142857 19.2 19 2 pale yolk sac 5.86094617820814e-07 2.09771275083349e-05 1.59044086092119 0.481927710843373 19.2 19 2 decreased body length 1.39071464795799e-19 3.84378076310612e-17 1.58986040805224 0.481751824817518 19.2 19 2 increased cell proliferation 5.44703250939603e-05 0.000944215565653144 1.58896823049441 0.481481481481481 19.2 19 2 impaired limb coordination 5.44703250939603e-05 0.000944215565653144 1.58896823049441 0.481481481481481 19.2 19 2 neurodegeneration 5.44703250939603e-05 0.000944215565653144 1.58896823049441 0.481481481481481 19.2 19 2 abnormal heart valve morphology 0.00401631313140904 0.0302286805276247 1.58896823049441 0.481481481481481 19.2 19 2 thin epidermis 0.00401631313140904 0.0302286805276247 1.58896823049441 0.481481481481481 19.2 19 2 abnormal fetal cardiomyocyte proliferation 0.00401631313140904 0.0302286805276247 1.58896823049441 0.481481481481481 19.2 19 2 abnormal neural tube morphology 3.59927588397545e-12 3.27336754511311e-10 1.58896823049441 0.481481481481481 19.2 19 2 increased neuron apoptosis 8.31672738651145e-07 2.83395333889688e-05 1.58896823049441 0.481481481481481 19.2 19 2 abnormal somite development 1.18039057690126e-06 3.78867298069922e-05 1.58742103650171 0.481012658227848 19.2 19 2 abnormal neurocranium morphology 2.37934998112883e-06 6.76415208920912e-05 1.5840790974775 0.48 19.2 19 2 abnormal inner ear vestibule morphology 0.00583021785232361 0.040673376371256 1.5840790974775 0.48 19.2 19 2 abnormal egg cylinder morphology 0.00583021785232361 0.040673376371256 1.5840790974775 0.48 19.2 19 2 polydactyly 7.57099970868137e-08 3.42415668642635e-06 1.58273209144223 0.479591836734694 19.2 19 2 overriding aortic valve 0.000158608567630635 0.00240572446330003 1.58132896015549 0.479166666666667 19.2 19 2 abnormal nasal cavity morphology 0.00848569231712542 0.0551126883520874 1.57833968045765 0.478260869565217 19.2 19 2 abnormal sacral vertebrae morphology 0.00848569231712542 0.0551126883520874 1.57833968045765 0.478260869565217 19.2 19 2 abnormal ulna morphology 0.00848569231712542 0.0551126883520874 1.57833968045765 0.478260869565217 19.2 19 2 decreased white adipose tissue amount 9.69689182185945e-06 0.000231932869296879 1.57619810694279 0.477611940298507 19.2 19 2 increased oxygen consumption 6.12553942103422e-07 2.17675418711752e-05 1.57333437491709 0.476744186046512 19.2 19 2 embryonic lethality, complete penetrance 9.84984919425041e-22 3.76946151856891e-19 1.57249231202051 0.476489028213166 19.2 19 2 abnormal optic nerve morphology 0.000464715966278477 0.00570854798082821 1.57150704114831 0.476190476190476 19.2 19 2 small ears 0.012388824637399 0.070042166073141 1.57150704114831 0.476190476190476 19.2 19 2 trunk curl 0.012388824637399 0.070042166073141 1.57150704114831 0.476190476190476 19.2 19 2 dry skin 0.012388824637399 0.070042166073141 1.57150704114831 0.476190476190476 19.2 19 2 vascular ring 0.012388824637399 0.070042166073141 1.57150704114831 0.476190476190476 19.2 19 2 abnormal retinal pigment epithelium morphology 1.74567207007213e-06 5.20043026862804e-05 1.56757827354544 0.475 19.2 19 2 decreased embryo size 1.68409523151468e-31 1.04729672209819e-28 1.56723306802385 0.47489539748954 19.2 19 2 abnormal motor coordination/ balance 1.11716416843632e-07 4.9184882636909e-06 1.56674489859938 0.474747474747475 19.2 19 2 abnormal CNS synaptic transmission 1.11716416843632e-07 4.9184882636909e-06 1.56674489859938 0.474747474747475 19.2 19 2 abnormal thoracic vertebrae morphology 3.97134504780369e-05 0.000734477383376333 1.56617989863595 0.474576271186441 19.2 19 2 abnormal cornea morphology 2.47578252691233e-06 6.95876727197109e-05 1.56546278329774 0.474358974358974 19.2 19 2 incomplete somite formation 0.000955666862788744 0.0102026666145365 1.56323595145806 0.473684210526316 19.2 19 2 decreased neuron apoptosis 0.000955666862788744 0.0102026666145365 1.56323595145806 0.473684210526316 19.2 19 2 impaired branching involved in ureteric bud morphogenesis 0.000955666862788744 0.0102026666145365 1.56323595145806 0.473684210526316 19.2 19 2 abnormal triglyceride level 0.0181535728372625 0.0929156634417498 1.56323595145806 0.473684210526316 19.2 19 2 abnormal stationary movement 0.0181535728372625 0.0929156634417498 1.56323595145806 0.473684210526316 19.2 19 2 stereotypic behavior 0.0181535728372625 0.0929156634417498 1.56323595145806 0.473684210526316 19.2 19 2 unresponsive to tactile stimuli 0.0181535728372625 0.0929156634417498 1.56323595145806 0.473684210526316 19.2 19 2 delayed sexual maturation 0.0181535728372625 0.0929156634417498 1.56323595145806 0.473684210526316 19.2 19 2 increased susceptibility to ischemic brain injury 0.0181535728372625 0.0929156634417498 1.56323595145806 0.473684210526316 19.2 19 2 abnormal digestive system development 0.0181535728372625 0.0929156634417498 1.56323595145806 0.473684210526316 19.2 19 2 maternal imprinting 0.0181535728372625 0.0929156634417498 1.56323595145806 0.473684210526316 19.2 19 2 abnormal sternebra morphology 0.0181535728372625 0.0929156634417498 1.56323595145806 0.473684210526316 19.2 19 2 decreased liver regeneration 0.0181535728372625 0.0929156634417498 1.56323595145806 0.473684210526316 19.2 19 2 abnormal rostral-caudal axis patterning 8.05511663761511e-05 0.00132258103208367 1.56007789903087 0.472727272727273 19.2 19 2 abnormal uterus morphology 0.00137259590921587 0.0136300691583812 1.55841114913874 0.472222222222222 19.2 19 2 abnormal limb bone morphology 0.00137259590921587 0.0136300691583812 1.55841114913874 0.472222222222222 19.2 19 2 abnormal pharyngeal arch morphology 0.00137259590921587 0.0136300691583812 1.55841114913874 0.472222222222222 19.2 19 2 narrow eye opening 0.00137259590921587 0.0136300691583812 1.55841114913874 0.472222222222222 19.2 19 2 short limbs 8.98945845087566e-07 3.02179431034503e-05 1.55525007175712 0.471264367816092 19.2 19 2 postnatal growth retardation 9.8732807113128e-39 1.22798928846953e-35 1.55301872301716 0.470588235294118 19.2 19 2 abnormal extraembryonic tissue morphology 1.15559247663918e-07 5.04304611515781e-06 1.55301872301716 0.470588235294118 19.2 19 2 pericardial edema 1.42469268292262e-05 0.000323645940526942 1.55301872301716 0.470588235294118 19.2 19 2 decreased circulating alanine transaminase level 1.42469268292262e-05 0.000323645940526942 1.55301872301716 0.470588235294118 19.2 19 2 impaired synaptic plasticity 0.0019737564244338 0.0181170446707715 1.55301872301716 0.470588235294118 19.2 19 2 abnormal direction of heart looping 0.0019737564244338 0.0181170446707715 1.55301872301716 0.470588235294118 19.2 19 2 abnormal adipose tissue morphology 0.0267182420212007 0.123764668580515 1.55301872301716 0.470588235294118 19.2 19 2 increased incidence of corneal inflammation 0.0267182420212007 0.123764668580515 1.55301872301716 0.470588235294118 19.2 19 2 hyperlipidemia 0.0267182420212007 0.123764668580515 1.55301872301716 0.470588235294118 19.2 19 2 abnormal duodenum morphology 0.0267182420212007 0.123764668580515 1.55301872301716 0.470588235294118 19.2 19 2 abnormal testis development 0.0267182420212007 0.123764668580515 1.55301872301716 0.470588235294118 19.2 19 2 increased brain size 0.0267182420212007 0.123764668580515 1.55301872301716 0.470588235294118 19.2 19 2 increased circulating magnesium level 0.0267182420212007 0.123764668580515 1.55301872301716 0.470588235294118 19.2 19 2 decreased body fat mass 0.0267182420212007 0.123764668580515 1.55301872301716 0.470588235294118 19.2 19 2 abnormal liver physiology 1.63380741070497e-07 6.66245235103053e-06 1.55107744961339 0.47 19.2 19 2 short tail 1.80277611415795e-06 5.30698885676675e-05 1.55067983939816 0.469879518072289 19.2 19 2 abnormal vitelline vasculature morphology 2.11390860592525e-08 1.05174940773981e-06 1.54964259535842 0.469565217391304 19.2 19 2 increased circulating LDL cholesterol level 0.000233490614157844 0.00326905173830299 1.54905694056048 0.469387755102041 19.2 19 2 retinal degeneration 3.2662433705998e-07 1.2404244861629e-05 1.54695224363037 0.46875 19.2 19 2 abnormal auditory brainstem response waveform shape 0.00284194863217353 0.0236433017475975 1.54695224363037 0.46875 19.2 19 2 increased insulin sensitivity 5.06797083709512e-10 3.70781689919827e-08 1.5462310537732 0.468531468531469 19.2 19 2 increased cellular sensitivity to gamma-irradiation 0.000333268299771352 0.00431773383167312 1.54475798512877 0.468085106382979 19.2 19 2 limb grasping 3.20120741613344e-12 3.00490696137054e-10 1.54128575189546 0.467032967032967 19.2 19 2 abnormal rib morphology 2.00381658761158e-09 1.40408274977008e-07 1.54007690032535 0.466666666666667 19.2 19 2 abnormal ectoderm development 0.000475967473947477 0.00577971683295187 1.54007690032535 0.466666666666667 19.2 19 2 abnormal cell migration 0.000475967473947477 0.00577971683295187 1.54007690032535 0.466666666666667 19.2 19 2 abnormal metabolism 0.000475967473947477 0.00577971683295187 1.54007690032535 0.466666666666667 19.2 19 2 abnormal response to new environment 0.00409805158296006 0.0306898939387893 1.54007690032535 0.466666666666667 19.2 19 2 abnormal microglial cell physiology 0.00409805158296006 0.0306898939387893 1.54007690032535 0.466666666666667 19.2 19 2 decreased chondrocyte number 0.0395368542074254 0.160378204330247 1.54007690032535 0.466666666666667 19.2 19 2 decreased hepatocyte number 0.0395368542074254 0.160378204330247 1.54007690032535 0.466666666666667 19.2 19 2 abnormal enteric neuron morphology 0.0395368542074254 0.160378204330247 1.54007690032535 0.466666666666667 19.2 19 2 vagina atresia 0.0395368542074254 0.160378204330247 1.54007690032535 0.466666666666667 19.2 19 2 abnormal prostate gland morphology 0.0395368542074254 0.160378204330247 1.54007690032535 0.466666666666667 19.2 19 2 audiogenic seizures 0.0395368542074254 0.160378204330247 1.54007690032535 0.466666666666667 19.2 19 2 abnormal cricoid cartilage morphology 0.0395368542074254 0.160378204330247 1.54007690032535 0.466666666666667 19.2 19 2 abnormal lymph node B cell domain morphology 0.0395368542074254 0.160378204330247 1.54007690032535 0.466666666666667 19.2 19 2 greasy coat 0.0395368542074254 0.160378204330247 1.54007690032535 0.466666666666667 19.2 19 2 abnormal ear development 0.0395368542074254 0.160378204330247 1.54007690032535 0.466666666666667 19.2 19 2 immune system phenotype 0.0395368542074254 0.160378204330247 1.54007690032535 0.466666666666667 19.2 19 2 ostium primum atrial septal defect 0.0395368542074254 0.160378204330247 1.54007690032535 0.466666666666667 19.2 19 2 abnormal branching involved in lung morphogenesis 0.0395368542074254 0.160378204330247 1.54007690032535 0.466666666666667 19.2 19 2 heterochrony 0.0395368542074254 0.160378204330247 1.54007690032535 0.466666666666667 19.2 19 2 decreased brown adipose tissue mass 0.0395368542074254 0.160378204330247 1.54007690032535 0.466666666666667 19.2 19 2 postnatal lethality, incomplete penetrance 6.19747829502298e-35 6.16649090354786e-32 1.53968955704056 0.466549295774648 19.2 19 2 abnormal fertility/fecundity 1.0288389538199e-05 0.000243736847393048 1.53706305120534 0.465753424657534 19.2 19 2 astrocytosis 1.0288389538199e-05 0.000243736847393048 1.53706305120534 0.465753424657534 19.2 19 2 embryonic lethality during organogenesis, incomplete penetrance 7.4771608131519e-15 1.19996371114293e-12 1.53529405280881 0.465217391304348 19.2 19 2 abnormal vasculogenesis 0.000680204688118042 0.00786981005438897 1.53496036577277 0.465116279069767 19.2 19 2 rib bifurcation 0.00591910040056068 0.040673376371256 1.53221936511961 0.464285714285714 19.2 19 2 abnormal circulating cholesterol level 0.00591910040056068 0.040673376371256 1.53221936511961 0.464285714285714 19.2 19 2 shortened head 0.00591910040056068 0.040673376371256 1.53221936511961 0.464285714285714 19.2 19 2 abnormal jaw morphology 0.00591910040056068 0.040673376371256 1.53221936511961 0.464285714285714 19.2 19 2 small superior cervical ganglion 0.00591910040056068 0.040673376371256 1.53221936511961 0.464285714285714 19.2 19 2 premature aging 0.00591910040056068 0.040673376371256 1.53221936511961 0.464285714285714 19.2 19 2 abnormal hormone level 0.00591910040056068 0.040673376371256 1.53221936511961 0.464285714285714 19.2 19 2 hypoxia 0.00591910040056068 0.040673376371256 1.53221936511961 0.464285714285714 19.2 19 2 corneal vascularization 0.00591910040056068 0.040673376371256 1.53221936511961 0.464285714285714 19.2 19 2 abnormal mitotic spindle morphology 0.00591910040056068 0.040673376371256 1.53221936511961 0.464285714285714 19.2 19 2 decreased total body fat amount 1.02722152067332e-20 3.40695137689985e-18 1.53151359848436 0.464071856287425 19.2 19 2 microcephaly 2.0668522019862e-05 0.000424900401028154 1.53051120529227 0.463768115942029 19.2 19 2 perimembraneous ventricular septal defect 2.0668522019862e-05 0.000424900401028154 1.53051120529227 0.463768115942029 19.2 19 2 abnormal excitatory postsynaptic potential 3.69538741849746e-06 0.000100462035011065 1.52934465711751 0.463414634146341 19.2 19 2 increased bone trabecula number 0.000972755368733451 0.0103186736875243 1.52934465711751 0.463414634146341 19.2 19 2 abnormal small intestine morphology 0.000166799686007976 0.00247709981459606 1.52785406778308 0.462962962962963 19.2 19 2 abnormal neuronal precursor proliferation 0.000166799686007976 0.00247709981459606 1.52785406778308 0.462962962962963 19.2 19 2 axon degeneration 0.000166799686007976 0.00247709981459606 1.52785406778308 0.462962962962963 19.2 19 2 rib fusion 2.93011849300825e-05 0.000565013159020001 1.52694191610082 0.462686567164179 19.2 19 2 abnormal lipid homeostasis 8.07195612211781e-09 4.50836073852511e-07 1.52315297834375 0.461538461538462 19.2 19 2 increased rib number 7.39419990390139e-06 0.000183930722609547 1.52315297834375 0.461538461538462 19.2 19 2 abnormal excitatory postsynaptic currents 7.39419990390139e-06 0.000183930722609547 1.52315297834375 0.461538461538462 19.2 19 2 abnormal snout morphology 0.000237339043242897 0.00328902991680616 1.52315297834375 0.461538461538462 19.2 19 2 liver hypoplasia 0.000237339043242897 0.00328902991680616 1.52315297834375 0.461538461538462 19.2 19 2 abnormal nasal bone morphology 0.00856533631158428 0.055202276155773 1.52315297834375 0.461538461538462 19.2 19 2 abnormal kidney cortex morphology 0.00856533631158428 0.055202276155773 1.52315297834375 0.461538461538462 19.2 19 2 thick skin 0.00856533631158428 0.055202276155773 1.52315297834375 0.461538461538462 19.2 19 2 absent myocardial trabeculae 0.058904187551849 0.196089550197519 1.52315297834375 0.461538461538462 19.2 19 2 lymphoid hypoplasia 0.058904187551849 0.196089550197519 1.52315297834375 0.461538461538462 19.2 19 2 abnormal pulmonary alveolus epithelial cell morphology 0.058904187551849 0.196089550197519 1.52315297834375 0.461538461538462 19.2 19 2 abnormal lung interstitium morphology 0.058904187551849 0.196089550197519 1.52315297834375 0.461538461538462 19.2 19 2 abnormal coping response 0.058904187551849 0.196089550197519 1.52315297834375 0.461538461538462 19.2 19 2 abnormal telomere length 0.058904187551849 0.196089550197519 1.52315297834375 0.461538461538462 19.2 19 2 abnormal retinal inner plexiform layer morphology 0.058904187551849 0.196089550197519 1.52315297834375 0.461538461538462 19.2 19 2 small otic vesicle 0.058904187551849 0.196089550197519 1.52315297834375 0.461538461538462 19.2 19 2 decreased luteinizing hormone level 0.058904187551849 0.196089550197519 1.52315297834375 0.461538461538462 19.2 19 2 abnormal exocrine pancreas morphology 0.058904187551849 0.196089550197519 1.52315297834375 0.461538461538462 19.2 19 2 abnormal vertebral arch development 0.058904187551849 0.196089550197519 1.52315297834375 0.461538461538462 19.2 19 2 empty decidua capsularis 0.058904187551849 0.196089550197519 1.52315297834375 0.461538461538462 19.2 19 2 abnormal aorta tunica media morphology 0.058904187551849 0.196089550197519 1.52315297834375 0.461538461538462 19.2 19 2 decreased grip strength 8.32333381803776e-14 1.03023738244234e-11 1.52199380560528 0.461187214611872 19.2 19 2 impaired balance 3.40542060158872e-07 1.28348238582605e-05 1.52066416628763 0.46078431372549 19.2 19 2 decreased rib number 1.87946347109843e-06 5.50019456983218e-05 1.52030063194236 0.460674157303371 19.2 19 2 gliosis 5.89165858173173e-05 0.00101072418772812 1.51912347311004 0.46031746031746 19.2 19 2 short stride length 0.000337831464515298 0.00434292386553903 1.51807580174927 0.46 19.2 19 2 decreased cell proliferation 9.48349981396307e-12 8.4250734954404e-10 1.51629192889175 0.459459459459459 19.2 19 2 abnormal humerus morphology 0.00199406805272983 0.0182697763578838 1.51629192889175 0.459459459459459 19.2 19 2 abnormal digit morphology 2.09367055767294e-05 0.000425139520849589 1.51257552710525 0.458333333333333 19.2 19 2 hydrops fetalis 2.09367055767294e-05 0.000425139520849589 1.51257552710525 0.458333333333333 19.2 19 2 oligodactyly 0.000481057303890425 0.005780821465833 1.51257552710525 0.458333333333333 19.2 19 2 small heart 0.000481057303890425 0.005780821465833 1.51257552710525 0.458333333333333 19.2 19 2 curly tail 0.000481057303890425 0.005780821465833 1.51257552710525 0.458333333333333 19.2 19 2 hemolytic anemia 0.0124209714908445 0.070042166073141 1.51257552710525 0.458333333333333 19.2 19 2 abnormal primitive streak formation 0.0124209714908445 0.070042166073141 1.51257552710525 0.458333333333333 19.2 19 2 abnormal impulse conducting system conduction 0.0124209714908445 0.070042166073141 1.51257552710525 0.458333333333333 19.2 19 2 abnormal osteoblast morphology 0.0124209714908445 0.070042166073141 1.51257552710525 0.458333333333333 19.2 19 2 abnormal retinal ganglion layer morphology 0.0124209714908445 0.070042166073141 1.51257552710525 0.458333333333333 19.2 19 2 decreased fatty acid level 0.0124209714908445 0.070042166073141 1.51257552710525 0.458333333333333 19.2 19 2 reduced male fertility 6.10418704904051e-14 8.2076569105342e-12 1.51196976998587 0.458149779735683 19.2 19 2 abnormal erythropoiesis 3.44722506518236e-07 1.28946952626182e-05 1.50864675950238 0.457142857142857 19.2 19 2 abnormal liver development 0.0028587192279706 0.0236641067539996 1.50864675950238 0.457142857142857 19.2 19 2 thick pulmonary interalveolar septum 0.0028587192279706 0.0236641067539996 1.50864675950238 0.457142857142857 19.2 19 2 abnormal midbrain development 0.0028587192279706 0.0236641067539996 1.50864675950238 0.457142857142857 19.2 19 2 decreased heart weight 7.47551888560139e-06 0.000184112408197361 1.50748268021264 0.45679012345679 19.2 19 2 impaired coordination 3.13938253271205e-20 9.76151756265152e-18 1.50701166547113 0.456647398843931 19.2 19 2 abnormal inner ear morphology 0.000685280897003567 0.00787360845864375 1.50659696770958 0.456521739130435 19.2 19 2 abnormal cell death 0.000685280897003567 0.00787360845864375 1.50659696770958 0.456521739130435 19.2 19 2 abnormal forelimb morphology 0.000685280897003567 0.00787360845864375 1.50659696770958 0.456521739130435 19.2 19 2 increased hepatocellular carcinoma incidence 0.000168190005535201 0.00249031332600483 1.50533832362628 0.456140350877193 19.2 19 2 abnormal nervous system morphology 1.05565393261564e-05 0.000248904185533784 1.50387256089636 0.455696202531646 19.2 19 2 abnormal learning/memory/conditioning 0.000238673452367829 0.00329833451536096 1.5000749029143 0.454545454545455 19.2 19 2 increased coping response 0.0180561448159928 0.0929156634417498 1.5000749029143 0.454545454545455 19.2 19 2 decreased cardiac output 0.0180561448159928 0.0929156634417498 1.5000749029143 0.454545454545455 19.2 19 2 abnormal circulating lipid level 0.0180561448159928 0.0929156634417498 1.5000749029143 0.454545454545455 19.2 19 2 failure of palatal shelf elevation 0.0180561448159928 0.0929156634417498 1.5000749029143 0.454545454545455 19.2 19 2 abnormal cerebral cortex pyramidal cell morphology 0.0180561448159928 0.0929156634417498 1.5000749029143 0.454545454545455 19.2 19 2 increased circulating creatine kinase level 0.0180561448159928 0.0929156634417498 1.5000749029143 0.454545454545455 19.2 19 2 embryonic lethality before implantation, incomplete penetrance 0.0180561448159928 0.0929156634417498 1.5000749029143 0.454545454545455 19.2 19 2 abnormal ear position 0.0885332578208608 0.267752557847284 1.5000749029143 0.454545454545455 19.2 19 2 abnormal large intestine morphology 0.0885332578208608 0.267752557847284 1.5000749029143 0.454545454545455 19.2 19 2 abnormal enteric ganglia morphology 0.0885332578208608 0.267752557847284 1.5000749029143 0.454545454545455 19.2 19 2 abnormal glossopharyngeal ganglion morphology 0.0885332578208608 0.267752557847284 1.5000749029143 0.454545454545455 19.2 19 2 abnormal food preference 0.0885332578208608 0.267752557847284 1.5000749029143 0.454545454545455 19.2 19 2 abnormal hemoglobin 0.0885332578208608 0.267752557847284 1.5000749029143 0.454545454545455 19.2 19 2 failure of somite differentiation 0.0885332578208608 0.267752557847284 1.5000749029143 0.454545454545455 19.2 19 2 abnormal bronchiole morphology 0.0885332578208608 0.267752557847284 1.5000749029143 0.454545454545455 19.2 19 2 abnormal vestibular ganglion morphology 0.0885332578208608 0.267752557847284 1.5000749029143 0.454545454545455 19.2 19 2 fused joints 0.0885332578208608 0.267752557847284 1.5000749029143 0.454545454545455 19.2 19 2 impaired luteinization 0.0885332578208608 0.267752557847284 1.5000749029143 0.454545454545455 19.2 19 2 abnormal pituitary gland development 0.0885332578208608 0.267752557847284 1.5000749029143 0.454545454545455 19.2 19 2 increased circulating triiodothyronine level 0.0885332578208608 0.267752557847284 1.5000749029143 0.454545454545455 19.2 19 2 abnormal aorta smooth muscle morphology 0.0885332578208608 0.267752557847284 1.5000749029143 0.454545454545455 19.2 19 2 aberrant origin of the right subclavian artery 0.0885332578208608 0.267752557847284 1.5000749029143 0.454545454545455 19.2 19 2 decreased embryonic cilium length 0.0885332578208608 0.267752557847284 1.5000749029143 0.454545454545455 19.2 19 2 abnormal phrenic nerve innervation pattern to diaphragm 0.0885332578208608 0.267752557847284 1.5000749029143 0.454545454545455 19.2 19 2 reduced sympathetic cervical ganglion size 0.0885332578208608 0.267752557847284 1.5000749029143 0.454545454545455 19.2 19 2 abnormal motor capabilities/coordination/movement 1.63570302460113e-08 8.47669015353189e-07 1.5000749029143 0.454545454545455 19.2 19 2 abnormal tail morphology 5.93085203970562e-05 0.00101395150850637 1.5000749029143 0.454545454545455 19.2 19 2 increased osteoblast cell number 0.00410226723000902 0.0306898939387893 1.5000749029143 0.454545454545455 19.2 19 2 embryonic growth arrest 1.22647770832398e-13 1.36379147727017e-11 1.49876479382878 0.454148471615721 19.2 19 2 embryonic lethality during organogenesis, complete penetrance 4.09317321750976e-31 2.26261519523456e-28 1.49686045669377 0.453571428571429 19.2 19 2 abnormal behavior 4.03039236187981e-16 8.02048080014082e-14 1.49575814060375 0.453237410071942 19.2 19 2 increased heart weight 8.33706910440824e-09 4.50836073852511e-07 1.49575814060375 0.453237410071942 19.2 19 2 decreased startle reflex 1.25381385556647e-07 5.42410776647233e-06 1.49494644170775 0.452991452991453 19.2 19 2 abnormal mesoderm development 0.000338754511649582 0.0043435662254038 1.4944142429033 0.452830188679245 19.2 19 2 enlarged heart 1.23358023069664e-13 1.36379147727017e-11 1.49360906281553 0.452586206896552 19.2 19 2 reduced female fertility 1.23358023069664e-13 1.36379147727017e-11 1.49360906281553 0.452586206896552 19.2 19 2 increased tumor incidence 6.37088036413473e-08 2.96216166463274e-06 1.49039700031485 0.451612903225806 19.2 19 2 increased lung adenoma incidence 0.00589299991201931 0.040673376371256 1.49039700031485 0.451612903225806 19.2 19 2 abnormal retinal photoreceptor layer morphology 0.00589299991201931 0.040673376371256 1.49039700031485 0.451612903225806 19.2 19 2 pale kidney 0.00589299991201931 0.040673376371256 1.49039700031485 0.451612903225806 19.2 19 2 preaxial polydactyly 0.00589299991201931 0.040673376371256 1.49039700031485 0.451612903225806 19.2 19 2 microphthalmia 2.16435656198103e-09 1.47502382135008e-07 1.48830960955811 0.450980392156863 19.2 19 2 kinked tail 9.66025915245947e-07 3.20398595223239e-05 1.48830960955811 0.450980392156863 19.2 19 2 abnormal response to novel object 0.000480887708458004 0.005780821465833 1.48830960955811 0.450980392156863 19.2 19 2 abnormal posture 1.49169568544586e-05 0.000334287659238431 1.48507415388516 0.45 19.2 19 2 abnormal circulating enzyme level 0.0263220484238288 0.12284445676224 1.48507415388516 0.45 19.2 19 2 abnormal heart right ventricle morphology 0.0263220484238288 0.12284445676224 1.48507415388516 0.45 19.2 19 2 abnormal postnatal subventricular zone morphology 0.0263220484238288 0.12284445676224 1.48507415388516 0.45 19.2 19 2 abnormal response to tactile stimuli 0.0263220484238288 0.12284445676224 1.48507415388516 0.45 19.2 19 2 abnormal neuron proliferation 0.0263220484238288 0.12284445676224 1.48507415388516 0.45 19.2 19 2 embryonic lethality between implantation and somite formation, complete penetrance 6.32537987479737e-14 8.28125391503076e-12 1.48170663879698 0.448979591836735 19.2 19 2 small liver 2.10219742972862e-05 0.000425139520849589 1.48084317338976 0.448717948717949 19.2 19 2 absent gastric milk in neonates 2.10219742972862e-05 0.000425139520849589 1.48084317338976 0.448717948717949 19.2 19 2 decreased body size 3.81121965769383e-42 6.32027259900893e-39 1.48052505455552 0.448621553884712 19.2 19 2 decreased body weight 3.84775595834869e-65 1.91425858927848e-61 1.47947613607299 0.448303715670436 19.2 19 2 decreased hair follicle number 0.00283467853982499 0.0236433017475975 1.47638950971039 0.447368421052632 19.2 19 2 abnormal compact bone morphology 0.00283467853982499 0.0236433017475975 1.47638950971039 0.447368421052632 19.2 19 2 abnormal liver morphology 2.03730402300538e-10 1.53569507794724e-08 1.47493398275372 0.446927374301676 19.2 19 2 pulmonary hypoplasia 0.000969598763998823 0.0103071663480644 1.47454171307746 0.446808510638298 19.2 19 2 neuron degeneration 0.000969598763998823 0.0103071663480644 1.47454171307746 0.446808510638298 19.2 19 2 abnormal seminal vesicle morphology 0.000336583189200482 0.0043380864411202 1.47328785107654 0.446428571428571 19.2 19 2 enhanced long term potentiation 0.000336583189200482 0.0043380864411202 1.47328785107654 0.446428571428571 19.2 19 2 increased or absent threshold for auditory brainstem response 7.92581699184556e-16 1.51657459747814e-13 1.47308393580304 0.44636678200692 19.2 19 2 neonatal lethality, incomplete penetrance 2.29339599825879e-14 3.35577796804043e-12 1.47238121239896 0.446153846153846 19.2 19 2 abnormal osteoblast physiology 0.000476318372162868 0.00577971683295187 1.46673990507176 0.444444444444444 19.2 19 2 increased brain weight 0.0122045548557245 0.070042166073141 1.46673990507176 0.444444444444444 19.2 19 2 abnormal eye muscle morphology 0.0122045548557245 0.070042166073141 1.46673990507176 0.444444444444444 19.2 19 2 abnormal skin appearance 0.0122045548557245 0.070042166073141 1.46673990507176 0.444444444444444 19.2 19 2 abnormal bone trabecula morphology 0.0122045548557245 0.070042166073141 1.46673990507176 0.444444444444444 19.2 19 2 increased circulating alkaline phosphatase level 2.14693743872595e-09 1.47502382135008e-07 1.46673990507176 0.444444444444444 19.2 19 2 abnormal myocardial trabeculae morphology 0.00137714036246157 0.0136479547873433 1.46673990507176 0.444444444444444 19.2 19 2 reduced long term depression 0.00404761788297436 0.030418276386401 1.46673990507176 0.444444444444444 19.2 19 2 underdeveloped hair follicles 0.0384987989466116 0.160378204330247 1.46673990507176 0.444444444444444 19.2 19 2 delayed kidney development 0.0384987989466116 0.160378204330247 1.46673990507176 0.444444444444444 19.2 19 2 abnormal radius morphology 0.0384987989466116 0.160378204330247 1.46673990507176 0.444444444444444 19.2 19 2 thick dermal layer 0.0384987989466116 0.160378204330247 1.46673990507176 0.444444444444444 19.2 19 2 abnormal thyroid cartilage morphology 0.0384987989466116 0.160378204330247 1.46673990507176 0.444444444444444 19.2 19 2 abnormal bile duct morphology 0.0384987989466116 0.160378204330247 1.46673990507176 0.444444444444444 19.2 19 2 abnormal body wall morphology 0.0384987989466116 0.160378204330247 1.46673990507176 0.444444444444444 19.2 19 2 long tibia 0.0384987989466116 0.160378204330247 1.46673990507176 0.444444444444444 19.2 19 2 absent inner cell mass 0.0384987989466116 0.160378204330247 1.46673990507176 0.444444444444444 19.2 19 2 abnormal glycogen homeostasis 0.0384987989466116 0.160378204330247 1.46673990507176 0.444444444444444 19.2 19 2 decreased lactate dehydrogenase level 0.0384987989466116 0.160378204330247 1.46673990507176 0.444444444444444 19.2 19 2 increased effector memory CD4-positive, alpha-beta T cell number 0.0384987989466116 0.160378204330247 1.46673990507176 0.444444444444444 19.2 19 2 abnormal metanephric mesenchyme morphology 0.0384987989466116 0.160378204330247 1.46673990507176 0.444444444444444 19.2 19 2 respiratory failure 8.27350319615014e-09 4.50836073852511e-07 1.46431152774548 0.443708609271523 19.2 19 2 abnormal nervous system physiology 4.83543557203735e-07 1.75593372050262e-05 1.46355134006073 0.443478260869565 19.2 19 2 extramedullary hematopoiesis 1.34325444417519e-06 4.17668178735722e-05 1.46328061284282 0.443396226415094 19.2 19 2 domed cranium 8.27931274943524e-05 0.00134168016053552 1.46150154826793 0.442857142857143 19.2 19 2 abnormal maternal nurturing 0.000235168528751989 0.00327720848891077 1.46072867595261 0.442622950819672 19.2 19 2 decreased bone mineral content 1.89175980295699e-11 1.5951703423239e-09 1.45968827091276 0.442307692307692 19.2 19 2 kidney failure 0.00195629312097013 0.0180566943911436 1.45821234748413 0.441860465116279 19.2 19 2 abnormal spatial learning 2.97411246729752e-09 1.9215856525721e-07 1.45774150074617 0.441717791411043 19.2 19 2 abnormal endoderm development 0.0057826704975684 0.040673376371256 1.45595505282858 0.441176470588235 19.2 19 2 abnormal brown adipose tissue morphology 0.0057826704975684 0.040673376371256 1.45595505282858 0.441176470588235 19.2 19 2 azoospermia 5.79904133644097e-09 3.48333642975906e-07 1.45290273615599 0.440251572327044 19.2 19 2 abnormal hindlimb morphology 0.000953807974915109 0.0102026666145365 1.45207250602104 0.44 19.2 19 2 diaphragmatic hernia 0.0175994207782537 0.0924455882325256 1.45207250602104 0.44 19.2 19 2 decreased erythrocyte cell number 8.09420302250733e-09 4.50836073852511e-07 1.45039089339102 0.439490445859873 19.2 19 2 impaired swimming 0.000164114417265305 0.00247709981459606 1.45007240615049 0.439393939393939 19.2 19 2 liver fibrosis 0.00277940985931946 0.0236433017475975 1.44885283305869 0.439024390243902 19.2 19 2 lethality at weaning, incomplete penetrance 0.00277940985931946 0.0236433017475975 1.44885283305869 0.439024390243902 19.2 19 2 cardiac hypertrophy 5.17386809540881e-06 0.00013476436531235 1.44803148791523 0.438775510204082 19.2 19 2 abnormal craniofacial bone morphology 0.000468140363938983 0.00573644904087793 1.4474406957945 0.43859649122807 19.2 19 2 failure of primitive streak formation 0.00826603979634381 0.0540388278407496 1.44382209405501 0.4375 19.2 19 2 neonatal lethality 0.00826603979634381 0.0540388278407496 1.44382209405501 0.4375 19.2 19 2 abnormal heart atrium morphology 0.00826603979634381 0.0540388278407496 1.44382209405501 0.4375 19.2 19 2 failure of tooth eruption 0.0565287815729648 0.191574038368869 1.44382209405501 0.4375 19.2 19 2 decreased mast cell number 0.0565287815729648 0.191574038368869 1.44382209405501 0.4375 19.2 19 2 reduced male mating frequency 0.0565287815729648 0.191574038368869 1.44382209405501 0.4375 19.2 19 2 intraventricular hemorrhage 0.0565287815729648 0.191574038368869 1.44382209405501 0.4375 19.2 19 2 abnormal olfaction 0.0565287815729648 0.191574038368869 1.44382209405501 0.4375 19.2 19 2 increased pancreatic beta cell number 0.0565287815729648 0.191574038368869 1.44382209405501 0.4375 19.2 19 2 bowed tibia 0.0565287815729648 0.191574038368869 1.44382209405501 0.4375 19.2 19 2 dystonia 0.0565287815729648 0.191574038368869 1.44382209405501 0.4375 19.2 19 2 decreased liver cholesterol level 0.0565287815729648 0.191574038368869 1.44382209405501 0.4375 19.2 19 2 dilated respiratory conducting tubes 0.0565287815729648 0.191574038368869 1.44382209405501 0.4375 19.2 19 2 embryonic lethality between somite formation and embryo turning, incomplete penetrance 0.0565287815729648 0.191574038368869 1.44382209405501 0.4375 19.2 19 2 hyperactivity 2.29597824658478e-18 5.43928179845681e-16 1.44104230565676 0.436657681940701 19.2 19 2 decreased liver weight 0.000114435455179345 0.00179030311168943 1.44091701941909 0.436619718309859 19.2 19 2 abnormal heart ventricle morphology 5.68921754463808e-05 0.000982772822381058 1.43853336843576 0.435897435897436 19.2 19 2 abnormal heart looping 0.00394933887961288 0.0299511599482836 1.43853336843576 0.435897435897436 19.2 19 2 failure of heart looping 0.00394933887961288 0.0299511599482836 1.43853336843576 0.435897435897436 19.2 19 2 abnormal pulmonary alveolus morphology 5.08018075364727e-06 0.000133020522365238 1.43769555051588 0.435643564356436 19.2 19 2 cardiac fibrosis 2.83648572038676e-05 0.000549086243537903 1.43654231879087 0.435294117647059 19.2 19 2 abnormal bone structure 3.70545392270547e-10 2.75143780081488e-08 1.4363411505625 0.435233160621762 19.2 19 2 preweaning lethality, complete penetrance 7.55487575744019e-35 6.26425114887749e-32 1.43601765030336 0.435135135135135 19.2 19 2 fragile skeleton 0.0254180313535831 0.120893600367186 1.4348542549615 0.434782608695652 19.2 19 2 abnormal blood vessel physiology 0.0254180313535831 0.120893600367186 1.4348542549615 0.434782608695652 19.2 19 2 bidirectional circling 0.0254180313535831 0.120893600367186 1.4348542549615 0.434782608695652 19.2 19 2 abnormal postnatal growth 0.0254180313535831 0.120893600367186 1.4348542549615 0.434782608695652 19.2 19 2 increased susceptibility to age related obesity 0.0254180313535831 0.120893600367186 1.4348542549615 0.434782608695652 19.2 19 2 abnormal crista ampullaris morphology 0.0254180313535831 0.120893600367186 1.4348542549615 0.434782608695652 19.2 19 2 abnormal chondrocyte physiology 0.0254180313535831 0.120893600367186 1.4348542549615 0.434782608695652 19.2 19 2 abnormal hepatocyte physiology 0.0254180313535831 0.120893600367186 1.4348542549615 0.434782608695652 19.2 19 2 abnormal neuron morphology 7.09893975899918e-06 0.000178369824752631 1.43340490722922 0.434343434343434 19.2 19 2 pallor 2.79561823061092e-09 1.83002640753807e-07 1.43321442152726 0.434285714285714 19.2 19 2 abnormal glucose homeostasis 1.41568719162292e-09 1.00614911118915e-07 1.43248911058519 0.434065934065934 19.2 19 2 postnatal lethality 7.68505055977766e-09 4.48815155805538e-07 1.43139677482907 0.433734939759036 19.2 19 2 thin ventricular wall 1.98206008527449e-05 0.000412583636997515 1.43007140744497 0.433333333333333 19.2 19 2 abnormal kidney development 0.000457063895820809 0.00565644995449882 1.43007140744497 0.433333333333333 19.2 19 2 epidermal hyperplasia 0.000457063895820809 0.00565644995449882 1.43007140744497 0.433333333333333 19.2 19 2 disorganized myocardium 0.0118225283052981 0.070042166073141 1.43007140744497 0.433333333333333 19.2 19 2 abnormal enzyme/coenzyme activity 2.11406916128604e-08 1.05174940773981e-06 1.42937073551579 0.43312101910828 19.2 19 2 short femur 2.77010675034974e-05 0.000538331292304295 1.42507115776858 0.431818181818182 19.2 19 2 abnormal astrocyte morphology 0.00270084539311251 0.0233681840534517 1.42507115776858 0.431818181818182 19.2 19 2 increased anxiety-related response 1.60412572294189e-07 6.5954755963933e-06 1.42453156247977 0.431654676258993 19.2 19 2 reduced fertility 1.60412572294189e-07 6.5954755963933e-06 1.42453156247977 0.431654676258993 19.2 19 2 distended abdomen 0.0013125750736067 0.0132724816894174 1.42360049609906 0.431372549019608 19.2 19 2 abnormal trophoblast layer morphology 0.0013125750736067 0.0132724816894174 1.42360049609906 0.431372549019608 19.2 19 2 abnormal dendritic spine morphology 0.0013125750736067 0.0132724816894174 1.42360049609906 0.431372549019608 19.2 19 2 abnormal vertebrae morphology 3.47792349233672e-06 9.55948584219623e-05 1.42300683450769 0.431192660550459 19.2 19 2 increased bone mineral content 3.47792349233672e-06 9.55948584219623e-05 1.42300683450769 0.431192660550459 19.2 19 2 abnormal forebrain development 0.000156511564642688 0.0023811774743039 1.42090428303827 0.430555555555556 19.2 19 2 neonatal lethality, complete penetrance 5.81908538597398e-21 2.06785355680147e-18 1.41849188187861 0.429824561403509 19.2 19 2 abnormal blood homeostasis 2.43293944717682e-06 6.87720099415038e-05 1.41849188187861 0.429824561403509 19.2 19 2 increased grip strength 2.69483668289469e-05 0.000525757352839259 1.41435633703348 0.428571428571429 19.2 19 2 myoclonus 0.0169186456970974 0.0895428322798505 1.41435633703348 0.428571428571429 19.2 19 2 translucent skin 0.083391675851831 0.26283983695433 1.41435633703348 0.428571428571429 19.2 19 2 increased aggression towards males 0.083391675851831 0.26283983695433 1.41435633703348 0.428571428571429 19.2 19 2 abnormal fluid regulation 0.083391675851831 0.26283983695433 1.41435633703348 0.428571428571429 19.2 19 2 absent otoliths 0.083391675851831 0.26283983695433 1.41435633703348 0.428571428571429 19.2 19 2 abnormal prepulse inhibition 0.083391675851831 0.26283983695433 1.41435633703348 0.428571428571429 19.2 19 2 abnormal ventral body wall morphology 0.083391675851831 0.26283983695433 1.41435633703348 0.428571428571429 19.2 19 2 abnormal voluntary movement 0.083391675851831 0.26283983695433 1.41435633703348 0.428571428571429 19.2 19 2 abnormal vascular endothelial cell migration 0.083391675851831 0.26283983695433 1.41435633703348 0.428571428571429 19.2 19 2 abnormal uterus development 0.083391675851831 0.26283983695433 1.41435633703348 0.428571428571429 19.2 19 2 abnormal imprinting 0.083391675851831 0.26283983695433 1.41435633703348 0.428571428571429 19.2 19 2 skeletal muscle necrosis 0.083391675851831 0.26283983695433 1.41435633703348 0.428571428571429 19.2 19 2 abnormal pancreas development 0.083391675851831 0.26283983695433 1.41435633703348 0.428571428571429 19.2 19 2 abnormal maternal decidual layer morphology 0.083391675851831 0.26283983695433 1.41435633703348 0.428571428571429 19.2 19 2 increased circulating growth hormone level 0.083391675851831 0.26283983695433 1.41435633703348 0.428571428571429 19.2 19 2 increased pulmonary respiratory rate 0.083391675851831 0.26283983695433 1.41435633703348 0.428571428571429 19.2 19 2 decreased tongue size 0.083391675851831 0.26283983695433 1.41435633703348 0.428571428571429 19.2 19 2 increased stomach tumor incidence 0.083391675851831 0.26283983695433 1.41435633703348 0.428571428571429 19.2 19 2 decreased compact bone area 0.083391675851831 0.26283983695433 1.41435633703348 0.428571428571429 19.2 19 2 multiple persisting craniopharyngeal ducts 0.083391675851831 0.26283983695433 1.41435633703348 0.428571428571429 19.2 19 2 decreased exploration in new environment 5.40291978185387e-05 0.000944215565653144 1.41435633703348 0.428571428571429 19.2 19 2 organ of Corti degeneration 0.00184967331383553 0.0172647743645999 1.41435633703348 0.428571428571429 19.2 19 2 spina bifida 0.0038196371844336 0.0292617584348029 1.41435633703348 0.428571428571429 19.2 19 2 liver degeneration 0.0367719662636511 0.157030499709583 1.41435633703348 0.428571428571429 19.2 19 2 decreased cochlear outer hair cell number 0.0367719662636511 0.157030499709583 1.41435633703348 0.428571428571429 19.2 19 2 increased bone ossification 0.0367719662636511 0.157030499709583 1.41435633703348 0.428571428571429 19.2 19 2 abnormal heart morphology 3.09905614341334e-11 2.48674263120667e-09 1.41435633703348 0.428571428571429 19.2 19 2 abnormal artery morphology 0.00797563394976682 0.0525546740398542 1.41435633703348 0.428571428571429 19.2 19 2 impaired adaptive thermogenesis 0.00797563394976682 0.0525546740398542 1.41435633703348 0.428571428571429 19.2 19 2 decreased bone mineralization 0.00797563394976682 0.0525546740398542 1.41435633703348 0.428571428571429 19.2 19 2 postnatal lethality, complete penetrance 1.34302102278163e-17 3.03705890379029e-15 1.41069220144531 0.427461139896373 19.2 19 2 decreased circulating glucose level 4.9806781068671e-13 5.05691297584975e-11 1.40759716696403 0.426523297491039 19.2 19 2 abnormal embryo development 4.18920918212604e-07 1.55532206575202e-05 1.4074232177343 0.426470588235294 19.2 19 2 decreased mean corpuscular hemoglobin 0.000306544704638955 0.00408863245463486 1.4074232177343 0.426470588235294 19.2 19 2 abnormal long bone morphology 0.000621900454214788 0.00727989355227899 1.40662761388029 0.426229508196721 19.2 19 2 abnormal long bone epiphyseal plate proliferative zone 0.00126852657899419 0.012932212562492 1.40562574236044 0.425925925925926 19.2 19 2 cleft secondary palate 2.61243987454218e-05 0.000513711002997918 1.40432544102615 0.425531914893617 19.2 19 2 abnormal innervation 0.00260544453444327 0.0226609904875092 1.40432544102615 0.425531914893617 19.2 19 2 abnormal cell nucleus morphology 0.00260544453444327 0.0226609904875092 1.40432544102615 0.425531914893617 19.2 19 2 decreased bone marrow cell number 0.000211898529214026 0.0030556382111298 1.40143984080487 0.424657534246575 19.2 19 2 abnormal vascular development 0.000428636700812468 0.00538501915793442 1.40006990938668 0.424242424242424 19.2 19 2 abnormal aorta morphology 0.0113340827399589 0.069271574485621 1.40006990938668 0.424242424242424 19.2 19 2 abnormal epidermis stratum basale morphology 0.0113340827399589 0.069271574485621 1.40006990938668 0.424242424242424 19.2 19 2 abnormal locomotor coordination 0.0113340827399589 0.069271574485621 1.40006990938668 0.424242424242424 19.2 19 2 single kidney 0.0113340827399589 0.069271574485621 1.40006990938668 0.424242424242424 19.2 19 2 syndactyly 0.000871125616893375 0.00953301865421544 1.39837490949638 0.423728813559322 19.2 19 2 distended pericardium 0.00178082899816536 0.0168433921404423 1.39622356348177 0.423076923076923 19.2 19 2 abnormal skin condition 0.00178082899816536 0.0168433921404423 1.39622356348177 0.423076923076923 19.2 19 2 decreased kidney weight 0.00178082899816536 0.0168433921404423 1.39622356348177 0.423076923076923 19.2 19 2 abnormal tectorial membrane morphology 0.0242244160538114 0.116818079579442 1.39622356348177 0.423076923076923 19.2 19 2 abnormal skeletal muscle fiber morphology 0.000295680210703281 0.00395432539851835 1.39443582524428 0.422535211267606 19.2 19 2 irregular heartbeat 0.00366816830012667 0.0282494385342573 1.39340290981817 0.422222222222222 19.2 19 2 increased circulating corticosterone level 0.00366816830012667 0.0282494385342573 1.39340290981817 0.422222222222222 19.2 19 2 abnormal lipid level 0.000101419860614591 0.0016068911036866 1.39163575330604 0.421686746987952 19.2 19 2 abnormal nail morphology 0.0532953270261383 0.189448988911781 1.38954306796272 0.421052631578947 19.2 19 2 flaky skin 0.0532953270261383 0.189448988911781 1.38954306796272 0.421052631578947 19.2 19 2 thin dermal layer 0.0532953270261383 0.189448988911781 1.38954306796272 0.421052631578947 19.2 19 2 decreased grooming behavior 0.0532953270261383 0.189448988911781 1.38954306796272 0.421052631578947 19.2 19 2 increased malignant tumor incidence 0.0532953270261383 0.189448988911781 1.38954306796272 0.421052631578947 19.2 19 2 abnormal metatarsal bone morphology 0.0532953270261383 0.189448988911781 1.38954306796272 0.421052631578947 19.2 19 2 increased liver adenoma incidence 0.0532953270261383 0.189448988911781 1.38954306796272 0.421052631578947 19.2 19 2 osteoarthritis 0.0532953270261383 0.189448988911781 1.38954306796272 0.421052631578947 19.2 19 2 abnormal cochlear inner hair cell morphology 0.0532953270261383 0.189448988911781 1.38954306796272 0.421052631578947 19.2 19 2 abnormal blastocyst morphology 0.0532953270261383 0.189448988911781 1.38954306796272 0.421052631578947 19.2 19 2 decreased eye pigmentation 0.0532953270261383 0.189448988911781 1.38954306796272 0.421052631578947 19.2 19 2 eyelids fail to open 0.0532953270261383 0.189448988911781 1.38954306796272 0.421052631578947 19.2 19 2 thin interventricular septum 0.0532953270261383 0.189448988911781 1.38954306796272 0.421052631578947 19.2 19 2 thymus hypoplasia 7.51779117798016e-07 2.59729243822579e-05 1.38702577979612 0.420289855072464 19.2 19 2 abnormal coat/hair pigmentation 8.47065589656415e-06 0.000206576044536307 1.38489058001195 0.419642857142857 19.2 19 2 abnormal nose morphology 0.0161049654782217 0.0862456439764832 1.38394007172093 0.419354838709677 19.2 19 2 abnormal intestine morphology 0.00028410013778009 0.00384075593873899 1.38250146457777 0.418918918918919 19.2 19 2 decreased hemoglobin content 7.23944068472404e-07 2.53635333848606e-05 1.38092001700905 0.418439716312057 19.2 19 2 abnormal joint morphology 0.00170568832873599 0.0163818521920108 1.38006891068116 0.418181818181818 19.2 19 2 abnormal reflex 0.0107813597117613 0.0667960953499535 1.37506866100477 0.416666666666667 19.2 19 2 renal hypoplasia 0.0107813597117613 0.0667960953499535 1.37506866100477 0.416666666666667 19.2 19 2 abnormal retinal blood vessel morphology 0.0107813597117613 0.0667960953499535 1.37506866100477 0.416666666666667 19.2 19 2 insulin resistance 1.98121699615638e-06 5.7640669917415e-05 1.37506866100477 0.416666666666667 19.2 19 2 abnormal digestive system morphology 0.0347016455412537 0.152017895436771 1.37506866100477 0.416666666666667 19.2 19 2 abnormal foregut morphology 0.0347016455412537 0.152017895436771 1.37506866100477 0.416666666666667 19.2 19 2 abnormal adrenal gland morphology 0.0347016455412537 0.152017895436771 1.37506866100477 0.416666666666667 19.2 19 2 curly vibrissae 0.0347016455412537 0.152017895436771 1.37506866100477 0.416666666666667 19.2 19 2 abnormal startle reflex 0.0347016455412537 0.152017895436771 1.37506866100477 0.416666666666667 19.2 19 2 blindness 0.0347016455412537 0.152017895436771 1.37506866100477 0.416666666666667 19.2 19 2 increased body temperature 0.0347016455412537 0.152017895436771 1.37506866100477 0.416666666666667 19.2 19 2 abnormal inner cell mass apoptosis 0.0347016455412537 0.152017895436771 1.37506866100477 0.416666666666667 19.2 19 2 abnormal enteric nervous system morphology 0.123720580303727 0.349522934134606 1.37506866100477 0.416666666666667 19.2 19 2 myocarditis 0.123720580303727 0.349522934134606 1.37506866100477 0.416666666666667 19.2 19 2 increased circulating parathyroid hormone level 0.123720580303727 0.349522934134606 1.37506866100477 0.416666666666667 19.2 19 2 decreased synaptic depression 0.123720580303727 0.349522934134606 1.37506866100477 0.416666666666667 19.2 19 2 dilated bile duct 0.123720580303727 0.349522934134606 1.37506866100477 0.416666666666667 19.2 19 2 abnormal nucleotide metabolism 0.123720580303727 0.349522934134606 1.37506866100477 0.416666666666667 19.2 19 2 abnormal defecation 0.123720580303727 0.349522934134606 1.37506866100477 0.416666666666667 19.2 19 2 bowed ulna 0.123720580303727 0.349522934134606 1.37506866100477 0.416666666666667 19.2 19 2 absent cochlear hair cells 0.123720580303727 0.349522934134606 1.37506866100477 0.416666666666667 19.2 19 2 abnormal cochlear outer hair cell physiology 0.123720580303727 0.349522934134606 1.37506866100477 0.416666666666667 19.2 19 2 decreased renal glomerular filtration rate 0.123720580303727 0.349522934134606 1.37506866100477 0.416666666666667 19.2 19 2 hydrometra 0.123720580303727 0.349522934134606 1.37506866100477 0.416666666666667 19.2 19 2 abnormal behavioral response to addictive substance 0.123720580303727 0.349522934134606 1.37506866100477 0.416666666666667 19.2 19 2 impaired behavioral response to cocaine 0.123720580303727 0.349522934134606 1.37506866100477 0.416666666666667 19.2 19 2 abnormal aorta elastic tissue morphology 0.123720580303727 0.349522934134606 1.37506866100477 0.416666666666667 19.2 19 2 increased fibrosarcoma incidence 0.123720580303727 0.349522934134606 1.37506866100477 0.416666666666667 19.2 19 2 increased type II pneumocyte number 0.123720580303727 0.349522934134606 1.37506866100477 0.416666666666667 19.2 19 2 embryonic lethality between implantation and placentation, incomplete penetrance 0.123720580303727 0.349522934134606 1.37506866100477 0.416666666666667 19.2 19 2 increased spleen weight 1.12517290881156e-05 0.000264044114214033 1.37263491116229 0.415929203539823 19.2 19 2 increased startle reflex 9.34550635232689e-05 0.00149498051777576 1.37197861906993 0.415730337078652 19.2 19 2 decreased circulating cholesterol level 2.93101441215908e-08 1.41570841752344e-06 1.37056023916541 0.415300546448087 19.2 19 2 abnormal placenta development 0.00238385924107575 0.0212159207949049 1.36987972266136 0.415094339622642 19.2 19 2 sparse hair 0.000187515218016973 0.00273574255024763 1.36836100899987 0.414634146341463 19.2 19 2 hemopericardium 0.00725680092345089 0.0485249792932368 1.36836100899987 0.414634146341463 19.2 19 2 deafness 4.47018580509291e-05 0.000813481388853436 1.36673491154414 0.414141414141414 19.2 19 2 increased mean corpuscular hemoglobin 4.47018580509291e-05 0.000813481388853436 1.36673491154414 0.414141414141414 19.2 19 2 increased circulating triglyceride level 9.19321825350581e-07 3.06954770544909e-05 1.36558542885991 0.413793103448276 19.2 19 2 aphagia 0.0228786861475532 0.112694518400076 1.36558542885991 0.413793103448276 19.2 19 2 decreased bone strength 0.0228786861475532 0.112694518400076 1.36558542885991 0.413793103448276 19.2 19 2 premature death 5.95784581440703e-33 4.23432613238214e-30 1.36452806499707 0.413472706155633 19.2 19 2 decreased cardiac muscle contractility 3.09454879294244e-05 0.0005898613120647 1.36449120976628 0.413461538461538 19.2 19 2 spleen hyperplasia 0.000377341141895058 0.00481351841263568 1.36406811171674 0.413333333333333 19.2 19 2 abnormal immune system morphology 0.00490586232339235 0.0355553614185555 1.36311154221343 0.41304347826087 19.2 19 2 delayed wound healing 0.00490586232339235 0.0355553614185555 1.36311154221343 0.41304347826087 19.2 19 2 abnormal hair follicle morphology 0.00111225885453455 0.0116987057110135 1.36197276899521 0.412698412698413 19.2 19 2 increased lung adenocarcinoma incidence 0.00332848320611499 0.0262012720734526 1.35889138264001 0.411764705882353 19.2 19 2 increased kidney weight 0.00332848320611499 0.0262012720734526 1.35889138264001 0.411764705882353 19.2 19 2 overexpanded pulmonary alveoli 0.0152200713096322 0.0818593024491029 1.35889138264001 0.411764705882353 19.2 19 2 hydroureter 0.0773961592591997 0.248416704719044 1.35889138264001 0.411764705882353 19.2 19 2 decreased vasoconstriction 0.0773961592591997 0.248416704719044 1.35889138264001 0.411764705882353 19.2 19 2 abnormal ectoplacental cone morphology 0.0773961592591997 0.248416704719044 1.35889138264001 0.411764705882353 19.2 19 2 abnormal tarsal bone morphology 0.0773961592591997 0.248416704719044 1.35889138264001 0.411764705882353 19.2 19 2 pancytopenia 0.0773961592591997 0.248416704719044 1.35889138264001 0.411764705882353 19.2 19 2 abnormal tendon morphology 0.0773961592591997 0.248416704719044 1.35889138264001 0.411764705882353 19.2 19 2 abnormal ductus venosus valve morphology 0.0773961592591997 0.248416704719044 1.35889138264001 0.411764705882353 19.2 19 2 abnormal cell cytoskeleton morphology 0.0773961592591997 0.248416704719044 1.35889138264001 0.411764705882353 19.2 19 2 decreased insulin secretion 0.000123416162814396 0.00190681804348329 1.35673441219138 0.411111111111111 19.2 19 2 abnormal gait 2.00807933266818e-12 1.95886170196553e-10 1.35637840736005 0.411003236245955 19.2 19 2 abnormal neuron differentiation 2.04601556737845e-05 0.000424121976987825 1.35542482299042 0.410714285714286 19.2 19 2 small lens 0.0101942967009902 0.063395782609283 1.35391375852778 0.41025641025641 19.2 19 2 abnormal circulating hormone level 0.0101942967009902 0.063395782609283 1.35391375852778 0.41025641025641 19.2 19 2 enlarged liver 5.88623084376249e-05 0.00101072418772812 1.3530675624287 0.41 19.2 19 2 increased osteoclast cell number 0.00154534477719452 0.015193854281705 1.35252655180797 0.409836065573771 19.2 19 2 abnormal retina morphology 8.32091594130822e-09 4.50836073852511e-07 1.35149605538755 0.40952380952381 19.2 19 2 abnormal suckling behavior 0.000170328127290941 0.00249965319549389 1.35006741262287 0.409090909090909 19.2 19 2 abnormal circadian rhythm 0.00686459842190674 0.0460261147560459 1.35006741262287 0.409090909090909 19.2 19 2 decreased blood urea nitrogen level 0.00686459842190674 0.0460261147560459 1.35006741262287 0.409090909090909 19.2 19 2 abnormal abdominal fat pad morphology 0.0497290734197221 0.18830696432082 1.35006741262287 0.409090909090909 19.2 19 2 abnormal germ layer development 0.0497290734197221 0.18830696432082 1.35006741262287 0.409090909090909 19.2 19 2 abnormal retinal layer morphology 0.0497290734197221 0.18830696432082 1.35006741262287 0.409090909090909 19.2 19 2 abnormal basement membrane morphology 0.0497290734197221 0.18830696432082 1.35006741262287 0.409090909090909 19.2 19 2 abnormal blood-brain barrier function 0.0497290734197221 0.18830696432082 1.35006741262287 0.409090909090909 19.2 19 2 abnormal sperm midpiece morphology 0.0497290734197221 0.18830696432082 1.35006741262287 0.409090909090909 19.2 19 2 abnormal skin morphology 0.00105661680162363 0.0111606551763855 1.35006741262287 0.409090909090909 19.2 19 2 abnormal testis morphology 1.94930728745616e-05 0.00040747074601237 1.34876299966381 0.408695652173913 19.2 19 2 abnormal skeleton morphology 1.94930728745616e-05 0.00040747074601237 1.34876299966381 0.408695652173913 19.2 19 2 atelectasis 0.000723822356749196 0.00818412778369829 1.34795463106947 0.408450704225352 19.2 19 2 decreased circulating creatinine level 0.00464237012705949 0.0341149060297208 1.34700603526998 0.408163265306122 19.2 19 2 abnormal spleen morphology 1.87495774891661e-07 7.40310698480963e-06 1.34661896457019 0.408045977011494 19.2 19 2 increased blood urea nitrogen level 2.16804038917552e-06 6.19885111272885e-05 1.34282567171225 0.406896551724138 19.2 19 2 decreased circulating HDL cholesterol level 8.89790528104207e-06 0.000215936969625289 1.34069194447966 0.40625 19.2 19 2 abnormal tooth morphology 0.00146346322079089 0.0144746113785978 1.34069194447966 0.40625 19.2 19 2 scoliosis 0.0214684409447697 0.106063052333892 1.34069194447966 0.40625 19.2 19 2 abnormal long term potentiation 0.0214684409447697 0.106063052333892 1.34069194447966 0.40625 19.2 19 2 abnormal hepatocyte morphology 3.6762817292849e-05 0.000687575248240316 1.33790464313978 0.405405405405405 19.2 19 2 increased brown adipose tissue amount 0.0143057681897033 0.0771085555187151 1.33790464313978 0.405405405405405 19.2 19 2 abnormal long bone metaphysis morphology 0.0143057681897033 0.0771085555187151 1.33790464313978 0.405405405405405 19.2 19 2 abnormal hair follicle development 0.0143057681897033 0.0771085555187151 1.33790464313978 0.405405405405405 19.2 19 2 abnormal heart development 9.93921152624507e-07 3.27467399622975e-05 1.33677560968565 0.40506329113924 19.2 19 2 cataract 1.7603181381447e-05 0.00038076446683782 1.33643036805092 0.40495867768595 19.2 19 2 abnormal eye electrophysiology 1.7603181381447e-05 0.00038076446683782 1.33643036805092 0.40495867768595 19.2 19 2 disheveled coat 0.00959407226598258 0.0599629516623911 1.33578098497607 0.404761904761905 19.2 19 2 skin edema 0.00959407226598258 0.0599629516623911 1.33578098497607 0.404761904761905 19.2 19 2 abnormal brain wave pattern 0.00437689412117765 0.0325973776240401 1.33275885605078 0.403846153846154 19.2 19 2 increased susceptibility to injury 0.00437689412117765 0.0325973776240401 1.33275885605078 0.403846153846154 19.2 19 2 abnormal circulating amino acid level 0.00297243125705815 0.0242423696784661 1.33164544013094 0.403508771929825 19.2 19 2 abnormal blood vessel morphology 4.97412478812178e-06 0.000130932649846063 1.32006591456458 0.4 19.2 19 2 abnormal cell cycle 4.50901780547634e-05 0.000813481388853436 1.32006591456458 0.4 19.2 19 2 impaired ovarian folliculogenesis 0.0133902800338252 0.0742660458955187 1.32006591456458 0.4 19.2 19 2 head bobbing 0.0133902800338252 0.0742660458955187 1.32006591456458 0.4 19.2 19 2 perinatal lethality 0.0133902800338252 0.0742660458955187 1.32006591456458 0.4 19.2 19 2 abnormal nest building behavior 0.046103128716587 0.176026911254812 1.32006591456458 0.4 19.2 19 2 increased cellular sensitivity to ionizing radiation 0.046103128716587 0.176026911254812 1.32006591456458 0.4 19.2 19 2 abnormal energy expenditure 0.046103128716587 0.176026911254812 1.32006591456458 0.4 19.2 19 2 abnormal preimplantation embryo development 0.046103128716587 0.176026911254812 1.32006591456458 0.4 19.2 19 2 abnormal cell proliferation 0.0712775127610112 0.231164032585418 1.32006591456458 0.4 19.2 19 2 abnormal vascular regression 0.0712775127610112 0.231164032585418 1.32006591456458 0.4 19.2 19 2 brain inflammation 0.0712775127610112 0.231164032585418 1.32006591456458 0.4 19.2 19 2 increased mammary adenocarcinoma incidence 0.0712775127610112 0.231164032585418 1.32006591456458 0.4 19.2 19 2 abnormal trachea morphology 0.0712775127610112 0.231164032585418 1.32006591456458 0.4 19.2 19 2 decreased paired-pulse facilitation 0.0712775127610112 0.231164032585418 1.32006591456458 0.4 19.2 19 2 abnormal lens epithelium morphology 0.0712775127610112 0.231164032585418 1.32006591456458 0.4 19.2 19 2 intracranial hemorrhage 0.00279640670090455 0.0236433017475975 1.32006591456458 0.4 19.2 19 2 abnormal embryo turning 0.00411395852460404 0.0307311466364941 1.32006591456458 0.4 19.2 19 2 abnormal dermal layer morphology 0.0200496962162092 0.0993498393183675 1.32006591456458 0.4 19.2 19 2 ovary cysts 0.0200496962162092 0.0993498393183675 1.32006591456458 0.4 19.2 19 2 increased carcinoma incidence 0.0200496962162092 0.0993498393183675 1.32006591456458 0.4 19.2 19 2 holoprosencephaly 0.0200496962162092 0.0993498393183675 1.32006591456458 0.4 19.2 19 2 increased red blood cell distribution width 0.0200496962162092 0.0993498393183675 1.32006591456458 0.4 19.2 19 2 abnormal heart tube morphology 0.0302494580423899 0.134969554942502 1.32006591456458 0.4 19.2 19 2 emphysema 0.0302494580423899 0.134969554942502 1.32006591456458 0.4 19.2 19 2 abnormal spleen marginal zone morphology 0.0302494580423899 0.134969554942502 1.32006591456458 0.4 19.2 19 2 abnormal fat pad morphology 0.0302494580423899 0.134969554942502 1.32006591456458 0.4 19.2 19 2 hyperpigmentation 0.112628223614768 0.324826326077374 1.32006591456458 0.4 19.2 19 2 abnormal pup retrieval 0.112628223614768 0.324826326077374 1.32006591456458 0.4 19.2 19 2 abnormal apical ectodermal ridge morphology 0.112628223614768 0.324826326077374 1.32006591456458 0.4 19.2 19 2 absent egg cylinders 0.112628223614768 0.324826326077374 1.32006591456458 0.4 19.2 19 2 increased alcohol consumption 0.112628223614768 0.324826326077374 1.32006591456458 0.4 19.2 19 2 dilated ureter 0.112628223614768 0.324826326077374 1.32006591456458 0.4 19.2 19 2 decreased aggression towards males 0.112628223614768 0.324826326077374 1.32006591456458 0.4 19.2 19 2 abnormal zygomatic bone morphology 0.112628223614768 0.324826326077374 1.32006591456458 0.4 19.2 19 2 abnormal energy homeostasis 0.112628223614768 0.324826326077374 1.32006591456458 0.4 19.2 19 2 abnormal cerebral aqueduct morphology 0.112628223614768 0.324826326077374 1.32006591456458 0.4 19.2 19 2 decreased thymocyte apoptosis 0.112628223614768 0.324826326077374 1.32006591456458 0.4 19.2 19 2 abnormal secondary palate development 0.112628223614768 0.324826326077374 1.32006591456458 0.4 19.2 19 2 herniated liver 0.112628223614768 0.324826326077374 1.32006591456458 0.4 19.2 19 2 improved glucose tolerance 1.67249742003381e-07 6.76477615013674e-06 1.31333088438823 0.397959183673469 19.2 19 2 hypoactivity 4.73340725303673e-13 4.90597939247036e-11 1.3130629123653 0.397877984084881 19.2 19 2 hyperglycemia 0.000395279651771069 0.00501662313153334 1.31256554005001 0.397727272727273 19.2 19 2 abnormal spermatogenesis 4.69646911702065e-07 1.71800984243954e-05 1.30930450765237 0.396739130434783 19.2 19 2 cochlear ganglion degeneration 0.00385685101215718 0.029384125245761 1.30868603599075 0.396551724137931 19.2 19 2 increased circulating bilirubin level 0.00568482326124453 0.0401163059924703 1.30761246254039 0.39622641509434 19.2 19 2 no abnormal phenotype detected 4.77530238323811e-55 1.18785646783048e-51 1.30675112868281 0.395965417867435 19.2 19 2 abnormal cardiovascular system morphology 0.00840903108832816 0.0548295277384438 1.30631522795454 0.395833333333333 19.2 19 2 thymus atrophy 0.00840903108832816 0.0548295277384438 1.30631522795454 0.395833333333333 19.2 19 2 abnormal blood circulation 0.0124924593832726 0.070042166073141 1.30471631090686 0.395348837209302 19.2 19 2 seizures 7.89838258420721e-05 0.00130114083961692 1.30269662621505 0.394736842105263 19.2 19 2 abnormal ovary morphology 0.00167858657475498 0.0161871227200522 1.30147343689466 0.394366197183099 19.2 19 2 cachexia 0.000165709915866595 0.00247709981459606 1.30102650233529 0.394230769230769 19.2 19 2 decreased leukocyte cell number 1.70320201594604e-05 0.000371641667953138 1.30079487931547 0.394160583941606 19.2 19 2 abnormal tooth development 0.0280557737778968 0.129358178447671 1.30006491585906 0.393939393939394 19.2 19 2 decreased brown adipose tissue amount 0.0280557737778968 0.129358178447671 1.30006491585906 0.393939393939394 19.2 19 2 dilated heart atrium 0.0280557737778968 0.129358178447671 1.30006491585906 0.393939393939394 19.2 19 2 cardiovascular system phenotype 0.0280557737778968 0.129358178447671 1.30006491585906 0.393939393939394 19.2 19 2 myeloid hyperplasia 0.0280557737778968 0.129358178447671 1.30006491585906 0.393939393939394 19.2 19 2 abnormal nervous system electrophysiology 0.000738260217513103 0.00832844576446187 1.29649330894736 0.392857142857143 19.2 19 2 abnormal ovulation 0.0425624044059894 0.163259801017577 1.29649330894736 0.392857142857143 19.2 19 2 abnormal retinal inner nuclear layer morphology 0.0425624044059894 0.163259801017577 1.29649330894736 0.392857142857143 19.2 19 2 abnormal placenta morphology 0.00107606739744612 0.0113420239455391 1.29500137188298 0.392405063291139 19.2 19 2 small seminiferous tubules 0.00157103916031077 0.0154160154290849 1.29330782170179 0.391891891891892 19.2 19 2 abnormal myocardial fiber morphology 0.000327205921349003 0.00425236890440673 1.29284806065604 0.391752577319588 19.2 19 2 abnormal innervation pattern to muscle 0.06535760046224 0.21448157143776 1.29136882946535 0.391304347826087 19.2 19 2 blistering 0.06535760046224 0.21448157143776 1.29136882946535 0.391304347826087 19.2 19 2 abnormal lens development 0.06535760046224 0.21448157143776 1.29136882946535 0.391304347826087 19.2 19 2 decreased bone mineral density 5.07526705846192e-09 3.15618170198101e-07 1.29028999167967 0.390977443609023 19.2 19 2 decreased circulating LDL cholesterol level 0.00336872652455822 0.0263927786766569 1.28912686969198 0.390625 19.2 19 2 increased sacral vertebrae number 0.00336872652455822 0.0263927786766569 1.28912686969198 0.390625 19.2 19 2 increased circulating HDL cholesterol level 0.000211331843531521 0.0030556382111298 1.28863577374162 0.39047619047619 19.2 19 2 Leydig cell hyperplasia 0.0173157066644648 0.0913527472488998 1.28786918494106 0.390243902439024 19.2 19 2 abnormal cholesterol homeostasis 0.0173157066644648 0.0913527472488998 1.28786918494106 0.390243902439024 19.2 19 2 alopecia 0.000444800223434988 0.00556000279293735 1.28532733786552 0.389473684210526 19.2 19 2 decreased birth weight 0.000444800223434988 0.00556000279293735 1.28532733786552 0.389473684210526 19.2 19 2 diluted coat color 0.00729747868896396 0.0486661614981176 1.28339741693779 0.388888888888889 19.2 19 2 decreased tumor growth/size 0.00729747868896396 0.0486661614981176 1.28339741693779 0.388888888888889 19.2 19 2 cochlear outer hair cell degeneration 0.00214507838797106 0.0195096251922414 1.28339741693779 0.388888888888889 19.2 19 2 heart right ventricle hypertrophy 0.0259477285372214 0.12284445676224 1.28339741693779 0.388888888888889 19.2 19 2 abnormal lysosome morphology 0.0259477285372214 0.12284445676224 1.28339741693779 0.388888888888889 19.2 19 2 lowered ear position 0.102149024912665 0.298936117023828 1.28339741693779 0.388888888888889 19.2 19 2 abnormal megakaryocyte differentiation 0.102149024912665 0.298936117023828 1.28339741693779 0.388888888888889 19.2 19 2 abnormal thymus cortex morphology 0.102149024912665 0.298936117023828 1.28339741693779 0.388888888888889 19.2 19 2 increased circulating glycerol level 0.102149024912665 0.298936117023828 1.28339741693779 0.388888888888889 19.2 19 2 increased gastrointestinal tumor incidence 0.102149024912665 0.298936117023828 1.28339741693779 0.388888888888889 19.2 19 2 anemia 2.70339142858826e-07 1.04258700443617e-05 1.28252849519308 0.388625592417062 19.2 19 2 increased total body fat amount 3.96938137682346e-05 0.000734477383376333 1.28066096189101 0.388059701492537 19.2 19 2 decreased compact bone thickness 0.0031403520725502 0.0251987928402213 1.28066096189101 0.388059701492537 19.2 19 2 abnormal social investigation 0.00137019489846098 0.0136300691583812 1.27881385473444 0.3875 19.2 19 2 female infertility 1.09045936632569e-08 5.83337134136592e-07 1.27788335714429 0.387218045112782 19.2 19 2 pericardial effusion 0.00460801932434492 0.0339125682523905 1.27748314312702 0.387096774193548 19.2 19 2 abnormal capillary morphology 0.0391828217671277 0.160378204330247 1.27748314312702 0.387096774193548 19.2 19 2 inner cell mass degeneration 0.0391828217671277 0.160378204330247 1.27748314312702 0.387096774193548 19.2 19 2 decreased neuronal precursor cell number 0.0391828217671277 0.160378204330247 1.27748314312702 0.387096774193548 19.2 19 2 abnormal mitochondrial ATP synthesis coupled electron transport 0.0391828217671277 0.160378204330247 1.27748314312702 0.387096774193548 19.2 19 2 renal interstitial fibrosis 0.0160359273959844 0.0859684685291192 1.27506366747715 0.386363636363636 19.2 19 2 cochlear hair cell degeneration 0.0160359273959844 0.0859684685291192 1.27506366747715 0.386363636363636 19.2 19 2 embryonic lethality, incomplete penetrance 0.0160359273959844 0.0859684685291192 1.27506366747715 0.386363636363636 19.2 19 2 increased leukocyte cell number 2.41008742891716e-05 0.000479389039336646 1.27454640026925 0.386206896551724 19.2 19 2 incomplete embryo turning 0.00677980939941719 0.0459773468083138 1.27374781229916 0.385964912280702 19.2 19 2 increased susceptibility to pharmacologically induced seizures 0.000563301150834393 0.00665658723373185 1.27193851142942 0.385416666666667 19.2 19 2 increased circulating alanine transaminase level 0.00186172234810419 0.0173289113427543 1.26929414861979 0.384615384615385 19.2 19 2 abnormal hair growth 0.0100068567380724 0.0623861056038976 1.26929414861979 0.384615384615385 19.2 19 2 abnormal female meiosis 0.0100068567380724 0.0623861056038976 1.26929414861979 0.384615384615385 19.2 19 2 increased vascular permeability 0.023947902902808 0.116818079579442 1.26929414861979 0.384615384615385 19.2 19 2 increased hepatocyte apoptosis 0.023947902902808 0.116818079579442 1.26929414861979 0.384615384615385 19.2 19 2 abnormal response to injury 0.023947902902808 0.116818079579442 1.26929414861979 0.384615384615385 19.2 19 2 ventricular hypoplasia 0.0597773241308215 0.197078984460462 1.26929414861979 0.384615384615385 19.2 19 2 abnormal Schwann cell morphology 0.0597773241308215 0.197078984460462 1.26929414861979 0.384615384615385 19.2 19 2 abnormal ocular fundus morphology 0.0597773241308215 0.197078984460462 1.26929414861979 0.384615384615385 19.2 19 2 abnormal membranous labyrinth morphology 0.16423082577365 0.402090727472396 1.26929414861979 0.384615384615385 19.2 19 2 absent teeth 0.16423082577365 0.402090727472396 1.26929414861979 0.384615384615385 19.2 19 2 absent trabeculae carneae 0.16423082577365 0.402090727472396 1.26929414861979 0.384615384615385 19.2 19 2 short hair 0.16423082577365 0.402090727472396 1.26929414861979 0.384615384615385 19.2 19 2 abnormal sympathetic ganglion morphology 0.16423082577365 0.402090727472396 1.26929414861979 0.384615384615385 19.2 19 2 abnormal grip strength 0.16423082577365 0.402090727472396 1.26929414861979 0.384615384615385 19.2 19 2 abnormal tail bud morphology 0.16423082577365 0.402090727472396 1.26929414861979 0.384615384615385 19.2 19 2 increased synaptic depression 0.16423082577365 0.402090727472396 1.26929414861979 0.384615384615385 19.2 19 2 abnormal dopaminergic neuron morphology 0.16423082577365 0.402090727472396 1.26929414861979 0.384615384615385 19.2 19 2 tracheoesophageal fistula 0.16423082577365 0.402090727472396 1.26929414861979 0.384615384615385 19.2 19 2 vestibular hair cell degeneration 0.16423082577365 0.402090727472396 1.26929414861979 0.384615384615385 19.2 19 2 increased circulating thyroid-stimulating hormone level 0.16423082577365 0.402090727472396 1.26929414861979 0.384615384615385 19.2 19 2 increased renin activity 0.16423082577365 0.402090727472396 1.26929414861979 0.384615384615385 19.2 19 2 decreased litter size 7.84862684524257e-09 4.48815155805538e-07 1.26839073641437 0.384341637010676 19.2 19 2 decreased hematocrit 3.03137158472826e-05 0.000580041293616272 1.2658166304044 0.383561643835616 19.2 19 2 abnormal kidney morphology 5.76667804310951e-06 0.000147882594146752 1.26349166108324 0.382857142857143 19.2 19 2 abnormal inhibitory postsynaptic currents 0.003976024500595 0.0300792720899789 1.26182771245144 0.382352941176471 19.2 19 2 abnormal oocyte morphology 0.0360016848296796 0.156496652752261 1.26182771245144 0.382352941176471 19.2 19 2 decreased anxiety-related response 0.000140379361276671 0.00216218985248123 1.26103857692145 0.382113821138211 19.2 19 2 male infertility 3.26146066147161e-14 4.63593336880607e-12 1.25970504769583 0.381709741550696 19.2 19 2 spleen hypoplasia 0.000455182493306624 0.00565644995449882 1.25720563291865 0.380952380952381 19.2 19 2 increased circulating aspartate transaminase level 0.00582865703377311 0.040673376371256 1.25720563291865 0.380952380952381 19.2 19 2 abnormal anxiety-related response 0.0925116952209253 0.272495964312672 1.25720563291865 0.380952380952381 19.2 19 2 embryonic lethality at implantation, complete penetrance 0.0925116952209253 0.272495964312672 1.25720563291865 0.380952380952381 19.2 19 2 small testis 2.34748920559657e-08 1.15631275226168e-06 1.25549747309132 0.380434782608696 19.2 19 2 increased circulating free fatty acid level 0.00368725451583921 0.0283525366557961 1.25499224271985 0.380281690140845 19.2 19 2 abnormal axon extension 0.0136892647440782 0.0744149710541789 1.25406261883635 0.38 19.2 19 2 abnormal circulating protein level 0.0136892647440782 0.0744149710541789 1.25406261883635 0.38 19.2 19 2 decreased oocyte number 0.0136892647440782 0.0744149710541789 1.25406261883635 0.38 19.2 19 2 decreased respiratory quotient 0.0136892647440782 0.0744149710541789 1.25406261883635 0.38 19.2 19 2 abnormal placenta labyrinth morphology 0.00234273558320098 0.0208872930581091 1.2532271340803 0.379746835443038 19.2 19 2 decreased food intake 0.00234273558320098 0.0208872930581091 1.2532271340803 0.379746835443038 19.2 19 2 abnormal spermiogenesis 0.00856606174718729 0.055202276155773 1.25178664312159 0.379310344827586 19.2 19 2 glomerulosclerosis 0.00856606174718729 0.055202276155773 1.25178664312159 0.379310344827586 19.2 19 2 abnormal parietal bone morphology 0.0545913433417004 0.190087829643715 1.25178664312159 0.379310344827586 19.2 19 2 abnormal microglial cell morphology 0.0545913433417004 0.190087829643715 1.25178664312159 0.379310344827586 19.2 19 2 enlarged epididymis 0.0545913433417004 0.190087829643715 1.25178664312159 0.379310344827586 19.2 19 2 impaired glucose tolerance 1.50873671143019e-07 6.30753373055899e-06 1.25086891097854 0.379032258064516 19.2 19 2 abnormal branching of the mammary ductal tree 0.0330341391835368 0.146474904133775 1.2487110002638 0.378378378378378 19.2 19 2 abnormal vocalization 0.0330341391835368 0.146474904133775 1.2487110002638 0.378378378378378 19.2 19 2 impaired skeletal muscle contractility 0.0330341391835368 0.146474904133775 1.2487110002638 0.378378378378378 19.2 19 2 decreased circulating chloride level 0.0330341391835368 0.146474904133775 1.2487110002638 0.378378378378378 19.2 19 2 skin inflammation 0.0330341391835368 0.146474904133775 1.2487110002638 0.378378378378378 19.2 19 2 abnormal lung morphology 0.000253238630417246 0.00347069472817024 1.24796147385307 0.378151260504202 19.2 19 2 lethargy 0.0012848179553149 0.0130715119175698 1.24199750026238 0.376344086021505 19.2 19 2 small kidney 0.00186351106901981 0.0173289113427543 1.2375617949043 0.375 19.2 19 2 abnormal osteoclast morphology 0.0186762090316425 0.0953943941811308 1.2375617949043 0.375 19.2 19 2 abnormal phalanx morphology 0.0186762090316425 0.0953943941811308 1.2375617949043 0.375 19.2 19 2 abnormal crypts of Lieberkuhn morphology 0.0498114502605425 0.18830696432082 1.2375617949043 0.375 19.2 19 2 polydipsia 0.0498114502605425 0.18830696432082 1.2375617949043 0.375 19.2 19 2 abnormal lumbar vertebrae morphology 0.0498114502605425 0.18830696432082 1.2375617949043 0.375 19.2 19 2 increased fatty acid level 0.0498114502605425 0.18830696432082 1.2375617949043 0.375 19.2 19 2 decreased body height 0.083751173414832 0.26283983695433 1.2375617949043 0.375 19.2 19 2 increased stereotypic behavior 0.083751173414832 0.26283983695433 1.2375617949043 0.375 19.2 19 2 apnea 0.083751173414832 0.26283983695433 1.2375617949043 0.375 19.2 19 2 decreased ovulation rate 0.083751173414832 0.26283983695433 1.2375617949043 0.375 19.2 19 2 abnormal lung saccule morphology 0.083751173414832 0.26283983695433 1.2375617949043 0.375 19.2 19 2 vasculature congestion 0.14628788883985 0.364048116978069 1.2375617949043 0.375 19.2 19 2 abnormal hair follicle orientation 0.14628788883985 0.364048116978069 1.2375617949043 0.375 19.2 19 2 paternal imprinting 0.14628788883985 0.364048116978069 1.2375617949043 0.375 19.2 19 2 impaired muscle relaxation 0.14628788883985 0.364048116978069 1.2375617949043 0.375 19.2 19 2 abnormal molar crown morphology 0.14628788883985 0.364048116978069 1.2375617949043 0.375 19.2 19 2 small pancreas 0.14628788883985 0.364048116978069 1.2375617949043 0.375 19.2 19 2 decreased circulating prolactin level 0.14628788883985 0.364048116978069 1.2375617949043 0.375 19.2 19 2 decreased circulating triiodothyronine level 0.14628788883985 0.364048116978069 1.2375617949043 0.375 19.2 19 2 increased heart left ventricle size 0.14628788883985 0.364048116978069 1.2375617949043 0.375 19.2 19 2 abnormal pulmonary alveolus wall morphology 0.14628788883985 0.364048116978069 1.2375617949043 0.375 19.2 19 2 decreased adipocyte glucose uptake 0.14628788883985 0.364048116978069 1.2375617949043 0.375 19.2 19 2 increased thermal nociceptive threshold 0.00172450791860277 0.0164042579255234 1.23302860151637 0.373626373626374 19.2 19 2 cochlear inner hair cell degeneration 0.0171613830760216 0.0907310104178613 1.22947315572192 0.372549019607843 19.2 19 2 thrombocytopenia 0.000104505079255548 0.00165051672792492 1.22902688597392 0.372413793103448 19.2 19 2 increased circulating creatinine level 0.00250040565302915 0.0218237160067018 1.22796829261822 0.372093023255814 19.2 19 2 increased urine protein level 0.0039330167444255 0.0299185906781603 1.2269843436658 0.371794871794872 19.2 19 2 abnormal hippocampus pyramidal cell morphology 0.0454278599194577 0.173982758352042 1.22577549209568 0.371428571428571 19.2 19 2 wrinkled skin 0.0758298261916015 0.244969730716375 1.22228325422647 0.37037037037037 19.2 19 2 cryptorchism 0.0758298261916015 0.244969730716375 1.22228325422647 0.37037037037037 19.2 19 2 abnormal single cell response 0.0758298261916015 0.244969730716375 1.22228325422647 0.37037037037037 19.2 19 2 increased monocyte cell number 0.00136279954042722 0.0136300691583812 1.22106097097224 0.37 19.2 19 2 abnormal lymphocyte physiology 0.0254021188528009 0.120893600367186 1.21962611671728 0.369565217391304 19.2 19 2 increased circulating cholesterol level 2.9957956385344e-05 0.000575447231726203 1.21881085861787 0.369318181818182 19.2 19 2 hydronephrosis 0.00334717229093756 0.0263067648458362 1.21791795688994 0.369047619047619 19.2 19 2 abnormal cardiovascular system physiology 0.000285753254567908 0.00385263534275161 1.21585018446738 0.368421052631579 19.2 19 2 impaired righting response 0.00196827269439749 0.0181170446707715 1.21585018446738 0.368421052631579 19.2 19 2 abnormal frontal bone morphology 0.0414201886618058 0.160378204330247 1.21585018446738 0.368421052631579 19.2 19 2 increased bone marrow cell number 0.0414201886618058 0.160378204330247 1.21585018446738 0.368421052631579 19.2 19 2 increased grooming behavior 0.0414201886618058 0.160378204330247 1.21585018446738 0.368421052631579 19.2 19 2 abnormal reproductive system physiology 0.0414201886618058 0.160378204330247 1.21585018446738 0.368421052631579 19.2 19 2 hyporesponsive to tactile stimuli 0.0414201886618058 0.160378204330247 1.21585018446738 0.368421052631579 19.2 19 2 decreased total retina thickness 0.0414201886618058 0.160378204330247 1.21585018446738 0.368421052631579 19.2 19 2 small superior vagus ganglion 0.130647015346472 0.353345794900289 1.21585018446738 0.368421052631579 19.2 19 2 decreased germ cell number 0.130647015346472 0.353345794900289 1.21585018446738 0.368421052631579 19.2 19 2 increased left ventricle weight 0.130647015346472 0.353345794900289 1.21585018446738 0.368421052631579 19.2 19 2 absent amnion 0.130647015346472 0.353345794900289 1.21585018446738 0.368421052631579 19.2 19 2 Leydig cell hypoplasia 0.130647015346472 0.353345794900289 1.21585018446738 0.368421052631579 19.2 19 2 increased liver cholesterol level 0.130647015346472 0.353345794900289 1.21585018446738 0.368421052631579 19.2 19 2 increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 0.130647015346472 0.353345794900289 1.21585018446738 0.368421052631579 19.2 19 2 abnormal epidermis stratum corneum morphology 0.0232526370323262 0.114197304280181 1.21230543174298 0.36734693877551 19.2 19 2 increased sarcoma incidence 0.0232526370323262 0.114197304280181 1.21230543174298 0.36734693877551 19.2 19 2 abnormal craniofacial development 0.0232526370323262 0.114197304280181 1.21230543174298 0.36734693877551 19.2 19 2 abnormal visceral yolk sac morphology 0.00485537981793573 0.0355553614185555 1.21145289627762 0.367088607594937 19.2 19 2 increased metastatic potential 0.0686840137781431 0.224361765296298 1.2100604216842 0.366666666666667 19.2 19 2 abnormal synaptic transmission 0.0686840137781431 0.224361765296298 1.2100604216842 0.366666666666667 19.2 19 2 liver hemorrhage 0.0686840137781431 0.224361765296298 1.2100604216842 0.366666666666667 19.2 19 2 abnormal definitive hematopoiesis 0.00262102619238712 0.0227567282846875 1.20651185739774 0.365591397849462 19.2 19 2 osteoporosis 0.0344305070047867 0.152017895436771 1.20005992233144 0.363636363636364 19.2 19 2 muscular atrophy 0.0344305070047867 0.152017895436771 1.20005992233144 0.363636363636364 19.2 19 2 abnormal photoreceptor outer segment morphology 0.0344305070047867 0.152017895436771 1.20005992233144 0.363636363636364 19.2 19 2 increased body size 0.116958907678756 0.33421629276382 1.20005992233144 0.363636363636364 19.2 19 2 intestinal inflammation 0.116958907678756 0.33421629276382 1.20005992233144 0.363636363636364 19.2 19 2 increased skin papilloma incidence 0.116958907678756 0.33421629276382 1.20005992233144 0.363636363636364 19.2 19 2 abnormal chorion morphology 0.116958907678756 0.33421629276382 1.20005992233144 0.363636363636364 19.2 19 2 increased myocardial infarction size 0.116958907678756 0.33421629276382 1.20005992233144 0.363636363636364 19.2 19 2 abnormal vascular branching morphogenesis 0.116958907678756 0.33421629276382 1.20005992233144 0.363636363636364 19.2 19 2 parakeratosis 0.116958907678756 0.33421629276382 1.20005992233144 0.363636363636364 19.2 19 2 abnormal channel response 0.116958907678756 0.33421629276382 1.20005992233144 0.363636363636364 19.2 19 2 abnormal retinal outer plexiform layer morphology 0.116958907678756 0.33421629276382 1.20005992233144 0.363636363636364 19.2 19 2 decreased circulating estradiol level 0.116958907678756 0.33421629276382 1.20005992233144 0.363636363636364 19.2 19 2 decreased susceptibility to viral infection induced morbidity/mortality 0.116958907678756 0.33421629276382 1.20005992233144 0.363636363636364 19.2 19 2 increased bone volume 0.116958907678756 0.33421629276382 1.20005992233144 0.363636363636364 19.2 19 2 abnormal QRS complex 0.0622432653934829 0.204801749558583 1.20005992233144 0.363636363636364 19.2 19 2 abnormal seminiferous tubule morphology 0.000254302064689222 0.00347569442810132 1.19800502520416 0.363013698630137 19.2 19 2 abnormal locomotor activation 0.00348167075381761 0.0270720362517583 1.19676305441295 0.362637362637363 19.2 19 2 impaired wound healing 0.0564383689615911 0.191574038368869 1.1917261728708 0.361111111111111 19.2 19 2 abnormal trophoblast giant cell morphology 0.0564383689615911 0.191574038368869 1.1917261728708 0.361111111111111 19.2 19 2 head tilt 0.0564383689615911 0.191574038368869 1.1917261728708 0.361111111111111 19.2 19 2 abnormal male meiosis 0.0163040700533532 0.0868006403446963 1.19022336559102 0.360655737704918 19.2 19 2 decreased heart rate 0.00270823544642361 0.0233914433089539 1.18805932310813 0.36 19.2 19 2 increased circulating chloride level 0.0286320339444658 0.130377151110627 1.18805932310813 0.36 19.2 19 2 abnormal keratinocyte physiology 0.104928198557595 0.305452187141039 1.18805932310813 0.36 19.2 19 2 abnormal cochlear outer hair cell morphology 0.104928198557595 0.305452187141039 1.18805932310813 0.36 19.2 19 2 decreased lymphocyte cell number 0.000802535084883548 0.00899236947589111 1.18599672011662 0.359375 19.2 19 2 decreased B cell number 2.65865584796569e-05 0.000520740663135013 1.18549608832256 0.359223300970874 19.2 19 2 acanthosis 0.0512046686868444 0.189448988911781 1.18467453871181 0.358974358974359 19.2 19 2 decreased trabecular bone volume 0.0512046686868444 0.189448988911781 1.18467453871181 0.358974358974359 19.2 19 2 liver inflammation 0.0012450974430986 0.0127718758338465 1.18255904846411 0.358333333333333 19.2 19 2 abnormal femur morphology 0.013651244598793 0.0744149710541789 1.18214858020709 0.358208955223881 19.2 19 2 internal hemorrhage 0.013651244598793 0.0744149710541789 1.18214858020709 0.358208955223881 19.2 19 2 increased exploration in new environment 0.00724801100765026 0.0485249792932368 1.18154047908558 0.358024691358025 19.2 19 2 abnormal stria vascularis morphology 0.094311727183608 0.277305462611377 1.17863028086124 0.357142857142857 19.2 19 2 abnormal respiration 0.094311727183608 0.277305462611377 1.17863028086124 0.357142857142857 19.2 19 2 absent visceral yolk sac blood islands 0.209141464619105 0.441062363238475 1.17863028086124 0.357142857142857 19.2 19 2 abnormal endplate potential 0.209141464619105 0.441062363238475 1.17863028086124 0.357142857142857 19.2 19 2 decreased coping response 0.209141464619105 0.441062363238475 1.17863028086124 0.357142857142857 19.2 19 2 failure of zygotic cell division 0.209141464619105 0.441062363238475 1.17863028086124 0.357142857142857 19.2 19 2 abnormal decidualization 0.209141464619105 0.441062363238475 1.17863028086124 0.357142857142857 19.2 19 2 abnormal squamosal bone morphology 0.209141464619105 0.441062363238475 1.17863028086124 0.357142857142857 19.2 19 2 premature hair loss 0.209141464619105 0.441062363238475 1.17863028086124 0.357142857142857 19.2 19 2 thick epidermis 0.0124924090062128 0.070042166073141 1.17863028086124 0.357142857142857 19.2 19 2 dehydration 0.0124924090062128 0.070042166073141 1.17863028086124 0.357142857142857 19.2 19 2 abnormal action potential 0.0124924090062128 0.070042166073141 1.17863028086124 0.357142857142857 19.2 19 2 abnormal cartilage morphology 0.0464832075405676 0.177206097712125 1.17863028086124 0.357142857142857 19.2 19 2 abnormal spleen white pulp morphology 0.0464832075405676 0.177206097712125 1.17863028086124 0.357142857142857 19.2 19 2 increased circulating insulin level 0.000268725971744742 0.0036428111973572 1.17568370515908 0.35625 19.2 19 2 oxidative stress 0.00558843916502286 0.0394921659744158 1.17339192405741 0.355555555555556 19.2 19 2 abnormal cartilage development 0.0422208881778702 0.16219993720842 1.17339192405741 0.355555555555556 19.2 19 2 altered response to myocardial infarction 0.0422208881778702 0.16219993720842 1.17339192405741 0.355555555555556 19.2 19 2 abnormal autopod morphology 0.0422208881778702 0.16219993720842 1.17339192405741 0.355555555555556 19.2 19 2 abnormal ovarian follicle morphology 0.0422208881778702 0.16219993720842 1.17339192405741 0.355555555555556 19.2 19 2 albuminuria 0.0422208881778702 0.16219993720842 1.17339192405741 0.355555555555556 19.2 19 2 decreased osteoclast cell number 0.0422208881778702 0.16219993720842 1.17339192405741 0.355555555555556 19.2 19 2 infertility 0.00276590057652916 0.0236433017475975 1.1720211390994 0.355140186915888 19.2 19 2 hypoglycemia 0.00512467040413691 0.0367904133432481 1.1710262145331 0.354838709677419 19.2 19 2 osteopetrosis 0.0849096693842015 0.26283983695433 1.1710262145331 0.354838709677419 19.2 19 2 abnormal gastrulation 0.0348887525999806 0.152657470699123 1.16476404226287 0.352941176470588 19.2 19 2 abnormal retinal photoreceptor morphology 0.076556854791921 0.24699763462374 1.16476404226287 0.352941176470588 19.2 19 2 increased width of hypertrophic chondrocyte zone 0.076556854791921 0.24699763462374 1.16476404226287 0.352941176470588 19.2 19 2 enlarged sebaceous gland 0.18386519588384 0.441062363238475 1.16476404226287 0.352941176470588 19.2 19 2 abnormal touch/ nociception 0.18386519588384 0.441062363238475 1.16476404226287 0.352941176470588 19.2 19 2 abnormal involuntary movement 0.18386519588384 0.441062363238475 1.16476404226287 0.352941176470588 19.2 19 2 polyphagia 0.0317387990119229 0.141361257908967 1.16116909151514 0.351851851851852 19.2 19 2 increased granulocyte number 0.0138066053076498 0.0746607189190843 1.15951735738781 0.351351351351351 19.2 19 2 abnormal chromosome morphology 0.0691156600913704 0.225180359498735 1.15951735738781 0.351351351351351 19.2 19 2 abnormal calcium ion homeostasis 0.0691156600913704 0.225180359498735 1.15951735738781 0.351351351351351 19.2 19 2 increased trabecular bone volume 0.0691156600913704 0.225180359498735 1.15951735738781 0.351351351351351 19.2 19 2 abnormal respiratory electron transport chain 0.0691156600913704 0.225180359498735 1.15951735738781 0.351351351351351 19.2 19 2 enlarged spleen 3.54299351368544e-06 9.68483117065112e-05 1.15734945634569 0.350694444444444 19.2 19 2 decreased circulating phosphate level 0.0624704644128852 0.205413457008661 1.15505767524401 0.35 19.2 19 2 abnormal fibula morphology 0.162615209046335 0.401294972720991 1.15505767524401 0.35 19.2 19 2 absent placental labyrinth 0.162615209046335 0.401294972720991 1.15505767524401 0.35 19.2 19 2 abnormal optic stalk morphology 0.162615209046335 0.401294972720991 1.15505767524401 0.35 19.2 19 2 kidney atrophy 0.162615209046335 0.401294972720991 1.15505767524401 0.35 19.2 19 2 decreased circulating VLDL cholesterol level 0.162615209046335 0.401294972720991 1.15505767524401 0.35 19.2 19 2 abnormal induced retinal neovascularization 0.162615209046335 0.401294972720991 1.15505767524401 0.35 19.2 19 2 abnormal sperm mitochondrial sheath morphology 0.162615209046335 0.401294972720991 1.15505767524401 0.35 19.2 19 2 abnormal heart electrocardiography waveform feature 0.162615209046335 0.401294972720991 1.15505767524401 0.35 19.2 19 2 decreased muscle cell glucose uptake 0.162615209046335 0.401294972720991 1.15505767524401 0.35 19.2 19 2 abnormal long bone epiphyseal plate morphology 0.0263025250392442 0.12284445676224 1.15505767524401 0.35 19.2 19 2 increased erythrocyte cell number 0.0263025250392442 0.12284445676224 1.15505767524401 0.35 19.2 19 2 abnormal eye physiology 0.0263025250392442 0.12284445676224 1.15505767524401 0.35 19.2 19 2 abnormal renal glomerulus morphology 0.00397832382617209 0.0300792720899789 1.15051616407005 0.348623853211009 19.2 19 2 decreased T cell number 0.000597301113644188 0.00702499536732821 1.1478834039692 0.347826086956522 19.2 19 2 abnormal epidermal layer morphology 0.0199042333395602 0.0993498393183675 1.1478834039692 0.347826086956522 19.2 19 2 hyperkeratosis 0.0199042333395602 0.0993498393183675 1.1478834039692 0.347826086956522 19.2 19 2 increased lymphocyte cell number 0.0199042333395602 0.0993498393183675 1.1478834039692 0.347826086956522 19.2 19 2 abnormal carpal bone morphology 0.144479604860897 0.36192650260975 1.1478834039692 0.347826086956522 19.2 19 2 abnormal retinal cone cell morphology 0.144479604860897 0.36192650260975 1.1478834039692 0.347826086956522 19.2 19 2 abnormal circulating insulin level 0.144479604860897 0.36192650260975 1.1478834039692 0.347826086956522 19.2 19 2 abnormal cardiovascular development 0.144479604860897 0.36192650260975 1.1478834039692 0.347826086956522 19.2 19 2 abnormal heart left ventricle morphology 0.0181515612793303 0.0929156634417498 1.14589055083731 0.347222222222222 19.2 19 2 decreased body temperature 0.0420930391326483 0.16219993720842 1.14236473375781 0.346153846153846 19.2 19 2 increased leukemia incidence 0.128831602665887 0.353345794900289 1.14236473375781 0.346153846153846 19.2 19 2 decreased bone resorption 0.128831602665887 0.353345794900289 1.14236473375781 0.346153846153846 19.2 19 2 abnormal nerve conduction 0.128831602665887 0.353345794900289 1.14236473375781 0.346153846153846 19.2 19 2 increased circulating calcium level 0.038212164912833 0.160378204330247 1.14005692621487 0.345454545454545 19.2 19 2 abnormal platelet physiology 0.038212164912833 0.160378204330247 1.14005692621487 0.345454545454545 19.2 19 2 arrest of spermatogenesis 0.0125942037993221 0.0700851945208362 1.13934260483253 0.345238095238095 19.2 19 2 dermatitis 0.0347120259730998 0.152017895436771 1.13798785738326 0.344827586206897 19.2 19 2 abnormal enzyme/coenzyme level 0.0347120259730998 0.152017895436771 1.13798785738326 0.344827586206897 19.2 19 2 decreased retinal photoreceptor cell number 0.11521719236356 0.331716164356892 1.13798785738326 0.344827586206897 19.2 19 2 increased double-positive T cell number 0.11521719236356 0.331716164356892 1.13798785738326 0.344827586206897 19.2 19 2 increased retinal apoptosis 0.11521719236356 0.331716164356892 1.13798785738326 0.344827586206897 19.2 19 2 increased circulating follicle stimulating hormone level 0.103294450829928 0.301401696703161 1.13443164532894 0.34375 19.2 19 2 abnormal depression-related behavior 0.103294450829928 0.301401696703161 1.13443164532894 0.34375 19.2 19 2 abnormal embryonic hematopoiesis 0.103294450829928 0.301401696703161 1.13443164532894 0.34375 19.2 19 2 bradykinesia 0.103294450829928 0.301401696703161 1.13443164532894 0.34375 19.2 19 2 increased fibroblast apoptosis 0.103294450829928 0.301401696703161 1.13443164532894 0.34375 19.2 19 2 increased circulating serum albumin level 0.0927980695079889 0.273177748995411 1.13148506962679 0.342857142857143 19.2 19 2 increased sensitivity to induced morbidity/mortality 0.00046030211539623 0.00566832431706991 1.12994772578218 0.342391304347826 19.2 19 2 abnormal retinal outer nuclear layer morphology 0.0835173052347442 0.26283983695433 1.12900374271971 0.342105263157895 19.2 19 2 hunched posture 0.0179831032213985 0.0929156634417498 1.12790442067227 0.341772151898734 19.2 19 2 decreased B cell proliferation 0.0179831032213985 0.0929156634417498 1.12790442067227 0.341772151898734 19.2 19 2 circling 0.0149589925896456 0.080542194949661 1.12593857418744 0.341176470588235 19.2 19 2 decreased sensitivity to induced morbidity/mortality 0.0679507145414983 0.222404476871022 1.12505617718572 0.340909090909091 19.2 19 2 lethality, incomplete penetrance 0.0679507145414983 0.222404476871022 1.12505617718572 0.340909090909091 19.2 19 2 increased circulating glucose level 0.00232864120369838 0.0208363129287759 1.12346035282092 0.340425531914894 19.2 19 2 hepatic necrosis 0.0614080109594962 0.202187196905025 1.12346035282092 0.340425531914894 19.2 19 2 increased body length 0.0555553174476305 0.190087829643715 1.1220560273799 0.34 19.2 19 2 kidney inflammation 0.0555553174476305 0.190087829643715 1.1220560273799 0.34 19.2 19 2 increased B cell proliferation 0.0413623405017904 0.160378204330247 1.1186999275971 0.338983050847458 19.2 19 2 lung inflammation 0.00326140459863838 0.0259569774234075 1.11623220716858 0.338235294117647 19.2 19 2 obese 0.0233537510906737 0.114580780745662 1.11434135645062 0.337662337662338 19.2 19 2 increased sensitivity to xenobiotic induced morbidity/mortality 0.00852055350505627 0.055202276155773 1.11005542815658 0.336363636363636 19.2 19 2 abnormal trabecular bone morphology 0.00651024515113998 0.0443070719930525 1.1092990878694 0.336134453781513 19.2 19 2 abnormal retinal pigmentation 0.0207481828750674 0.102708666471105 1.10005492880382 0.333333333333333 19.2 19 2 increased food intake 0.0227741367168319 0.112402113260157 1.10005492880382 0.333333333333333 19.2 19 2 abnormal coat appearance 0.0365478384737411 0.156496652752261 1.10005492880382 0.333333333333333 19.2 19 2 decreased spleen weight 0.0365478384737411 0.156496652752261 1.10005492880382 0.333333333333333 19.2 19 2 abnormal muscle morphology 0.0896807720446387 0.268507750059251 1.10005492880382 0.333333333333333 19.2 19 2 impaired macrophage chemotaxis 0.0996736235086939 0.292725074944364 1.10005492880382 0.333333333333333 19.2 19 2 decreased B-1 B cell number 0.0996736235086939 0.292725074944364 1.10005492880382 0.333333333333333 19.2 19 2 abnormal epidermis stratum granulosum morphology 0.110977919781188 0.322497167588441 1.10005492880382 0.333333333333333 19.2 19 2 abnormal palate morphology 0.155332490903029 0.385233869512747 1.10005492880382 0.333333333333333 19.2 19 2 abnormal salivary gland morphology 0.19766696595904 0.441062363238475 1.10005492880382 0.333333333333333 19.2 19 2 abnormal retinal rod cell morphology 0.224723281369428 0.441062363238475 1.10005492880382 0.333333333333333 19.2 19 2 abnormal iron level 0.224723281369428 0.441062363238475 1.10005492880382 0.333333333333333 19.2 19 2 increased incidence of induced tumors 0.19766696595904 0.441062363238475 1.10005492880382 0.333333333333333 19.2 19 2 abnormal white adipose tissue morphology 0.224723281369428 0.441062363238475 1.10005492880382 0.333333333333333 19.2 19 2 hypoalgesia 0.19766696595904 0.441062363238475 1.10005492880382 0.333333333333333 19.2 19 2 absent allantois 0.224723281369428 0.441062363238475 1.10005492880382 0.333333333333333 19.2 19 2 abnormal redox activity 0.224723281369428 0.441062363238475 1.10005492880382 0.333333333333333 19.2 19 2 decreased cellular sensitivity to gamma-irradiation 0.224723281369428 0.441062363238475 1.10005492880382 0.333333333333333 19.2 19 2 decreased heart rate variability 0.224723281369428 0.441062363238475 1.10005492880382 0.333333333333333 19.2 19 2 decreased pulmonary respiratory rate 0.224723281369428 0.441062363238475 1.10005492880382 0.333333333333333 19.2 19 2 abnormal tumor vascularization 0.19766696595904 0.441062363238475 1.10005492880382 0.333333333333333 19.2 19 2 impaired leukocyte tethering or rolling 0.224723281369428 0.441062363238475 1.10005492880382 0.333333333333333 19.2 19 2 abnormal kidney physiology 0.0729269178335373 0.236205349102766 1.10005492880382 0.333333333333333 19.2 19 2 abnormal skeleton physiology 0.12382004354815 0.349605401051105 1.10005492880382 0.333333333333333 19.2 19 2 salivary gland inflammation 0.138483781656268 0.356602905662491 1.10005492880382 0.333333333333333 19.2 19 2 abnormal vasodilation 0.17484382058393 0.4263960820613 1.10005492880382 0.333333333333333 19.2 19 2 abnormal sensory capabilities/reflexes/nociception 0.17484382058393 0.4263960820613 1.10005492880382 0.333333333333333 19.2 19 2 abnormal cardiac muscle contractility 0.17484382058393 0.4263960820613 1.10005492880382 0.333333333333333 19.2 19 2 hypopigmentation 0.17484382058393 0.4263960820613 1.10005492880382 0.333333333333333 19.2 19 2 increased circulating total protein level 0.17484382058393 0.4263960820613 1.10005492880382 0.333333333333333 19.2 19 2 abnormal fontanelle morphology 0.257398085121274 0.480688991545924 1.10005492880382 0.333333333333333 19.2 19 2 increased airway responsiveness 0.257398085121274 0.480688991545924 1.10005492880382 0.333333333333333 19.2 19 2 altered righting response 0.257398085121274 0.480688991545924 1.10005492880382 0.333333333333333 19.2 19 2 abnormal rostral migratory stream morphology 0.257398085121274 0.480688991545924 1.10005492880382 0.333333333333333 19.2 19 2 abnormal trophectoderm morphology 0.257398085121274 0.480688991545924 1.10005492880382 0.333333333333333 19.2 19 2 abnormal dendritic cell morphology 0.257398085121274 0.480688991545924 1.10005492880382 0.333333333333333 19.2 19 2 abnormal Muller cell morphology 0.257398085121274 0.480688991545924 1.10005492880382 0.333333333333333 19.2 19 2 increased body weight 0.000525926367281534 0.0062745411923876 1.09023300979664 0.330357142857143 19.2 19 2 decreased double-positive T cell number 0.0167394376197178 0.0886887136933932 1.08905437951578 0.33 19.2 19 2 seminiferous tubule degeneration 0.0388763708308761 0.160378204330247 1.08498568320377 0.328767123287671 19.2 19 2 maternal effect 0.0471510499286949 0.179614451298053 1.08363619852317 0.328358208955224 19.2 19 2 abnormal lens morphology 0.00859606187035663 0.0553239428266807 1.08286657054126 0.328125 19.2 19 2 increased double-negative T cell number 0.057351045465369 0.194228353431049 1.08202124144638 0.327868852459016 19.2 19 2 abnormal dendritic cell physiology 0.016184150408162 0.0865765035275332 1.07949315443365 0.327102803738318 19.2 19 2 abnormal T cell differentiation 0.0194395151336811 0.0991913720923729 1.07827166288691 0.326732673267327 19.2 19 2 abnormal homeostasis 0.105687793208153 0.307483491936 1.07447225604094 0.325581395348837 19.2 19 2 increased susceptibility to weight loss 0.117586255665935 0.335816086072346 1.07255355558372 0.325 19.2 19 2 polyuria 0.0410933000274436 0.160378204330247 1.07148207351021 0.324675324675325 19.2 19 2 increased white adipose tissue amount 0.1310718044323 0.353345794900289 1.07032371451182 0.324324324324324 19.2 19 2 increased circulating phosphate level 0.1310718044323 0.353345794900289 1.07032371451182 0.324324324324324 19.2 19 2 increased erythroid progenitor cell number 0.1310718044323 0.353345794900289 1.07032371451182 0.324324324324324 19.2 19 2 thin skin 0.146424177301129 0.364048116978069 1.0677003720743 0.323529411764706 19.2 19 2 abnormal bone remodeling 0.146424177301129 0.364048116978069 1.0677003720743 0.323529411764706 19.2 19 2 decreased regulatory T cell number 0.146424177301129 0.364048116978069 1.0677003720743 0.323529411764706 19.2 19 2 increased eosinophil cell number 0.0667815915809142 0.219010163556393 1.06456928593918 0.32258064516129 19.2 19 2 abnormal CD8-positive, alpha beta T cell morphology 0.163995263690585 0.402090727472396 1.06456928593918 0.32258064516129 19.2 19 2 abnormal intestine physiology 0.163995263690585 0.402090727472396 1.06456928593918 0.32258064516129 19.2 19 2 increased hemoglobin content 0.0737639066160932 0.238760855832832 1.06276493121725 0.322033898305085 19.2 19 2 failure of blastocyst to hatch from the zona pellucida 0.184237063191176 0.441062363238475 1.06076725277511 0.321428571428571 19.2 19 2 enhanced coordination 0.184237063191176 0.441062363238475 1.06076725277511 0.321428571428571 19.2 19 2 abnormal pancreatic islet morphology 0.0902611946172164 0.268507750059251 1.05854342205651 0.320754716981132 19.2 19 2 testicular atrophy 0.100014813043293 0.29355380229521 1.05605273165167 0.32 19.2 19 2 mandible hypoplasia 0.207745289772794 0.441062363238475 1.05605273165167 0.32 19.2 19 2 abnormal vertebrae development 0.207745289772794 0.441062363238475 1.05605273165167 0.32 19.2 19 2 weight loss 0.00500160613058154 0.0361671373541325 1.05605273165167 0.32 19.2 19 2 decreased IgM level 0.0311095564833897 0.138682834681778 1.05469183895624 0.319587628865979 19.2 19 2 abnormal tibia morphology 0.110966813114931 0.322497167588441 1.05324408076961 0.319148936170213 19.2 19 2 small ovary 0.0374685462741826 0.159867939720462 1.05170086599926 0.318681318681319 19.2 19 2 abnormal oogenesis 0.23533072648984 0.445329161006829 1.05005243204001 0.318181818181818 19.2 19 2 testis hypoplasia 0.23533072648984 0.445329161006829 1.05005243204001 0.318181818181818 19.2 19 2 abnormal tracheal cartilage morphology 0.23533072648984 0.445329161006829 1.05005243204001 0.318181818181818 19.2 19 2 abnormal lysosome physiology 0.23533072648984 0.445329161006829 1.05005243204001 0.318181818181818 19.2 19 2 scaly skin 0.137227710425263 0.353551454876065 1.04639371276461 0.317073170731707 19.2 19 2 decreased neutrophil cell number 0.0235300746508731 0.115218623413478 1.04364185553183 0.316239316239316 19.2 19 2 increased B cell number 0.0235300746508731 0.115218623413478 1.04364185553183 0.316239316239316 19.2 19 2 increased inflammatory response 0.0390976470985204 0.160378204330247 1.04215730097204 0.315789473684211 19.2 19 2 decreased threshold for auditory brainstem response 0.153020034831172 0.380067235788858 1.04215730097204 0.315789473684211 19.2 19 2 abnormal long term depression 0.268143096456947 0.499255952422646 1.04215730097204 0.315789473684211 19.2 19 2 decreased tumor incidence 0.268143096456947 0.499255952422646 1.04215730097204 0.315789473684211 19.2 19 2 abnormal neurotransmitter level 0.268143096456947 0.499255952422646 1.04215730097204 0.315789473684211 19.2 19 2 abnormal response to novelty 0.268143096456947 0.499255952422646 1.04215730097204 0.315789473684211 19.2 19 2 decreased fertilization frequency 0.268143096456947 0.499255952422646 1.04215730097204 0.315789473684211 19.2 19 2 decreased circulating magnesium level 0.268143096456947 0.499255952422646 1.04215730097204 0.315789473684211 19.2 19 2 decreased liver glycogen level 0.268143096456947 0.499255952422646 1.04215730097204 0.315789473684211 19.2 19 2 shortened RR interval 0.268143096456947 0.499255952422646 1.04215730097204 0.315789473684211 19.2 19 2 impaired fertilization 0.0729208717928005 0.236205349102766 1.03719464715789 0.314285714285714 19.2 19 2 impaired behavioral response to xenobiotic 0.171002810039652 0.418259085519797 1.03719464715789 0.314285714285714 19.2 19 2 abnormal thrombosis 0.115615367636132 0.332670013874931 1.03534581534477 0.313725490196078 19.2 19 2 abnormal urine homeostasis 0.0445818316654345 0.17087412367915 1.03130149575358 0.3125 19.2 19 2 abnormal osteoclast physiology 0.0886910719108278 0.268066878952836 1.03130149575358 0.3125 19.2 19 2 abnormal diaphragm morphology 0.191586542263611 0.441062363238475 1.03130149575358 0.3125 19.2 19 2 abnormal tympanic ring morphology 0.307902719794649 0.553401745295658 1.03130149575358 0.3125 19.2 19 2 delayed hair appearance 0.307902719794649 0.553401745295658 1.03130149575358 0.3125 19.2 19 2 abnormal mouth morphology 0.307902719794649 0.553401745295658 1.03130149575358 0.3125 19.2 19 2 mixed cellular infiltration to dermis 0.307902719794649 0.553401745295658 1.03130149575358 0.3125 19.2 19 2 poor circulation 0.307902719794649 0.553401745295658 1.03130149575358 0.3125 19.2 19 2 abnormal meiosis 0.307902719794649 0.553401745295658 1.03130149575358 0.3125 19.2 19 2 abnormal pulmonary elastic fiber morphology 0.307902719794649 0.553401745295658 1.03130149575358 0.3125 19.2 19 2 increased thymus weight 0.307902719794649 0.553401745295658 1.03130149575358 0.3125 19.2 19 2 decreased circulating growth hormone level 0.307902719794649 0.553401745295658 1.03130149575358 0.3125 19.2 19 2 impaired behavioral response to addictive substance 0.307902719794649 0.553401745295658 1.03130149575358 0.3125 19.2 19 2 decreased skeletal muscle weight 0.307902719794649 0.553401745295658 1.03130149575358 0.3125 19.2 19 2 small placenta 0.142484211556137 0.35844188424091 1.02671793355023 0.311111111111111 19.2 19 2 abnormal CD4-positive, alpha-beta T cell physiology 0.0833018289976824 0.26283983695433 1.0225862718458 0.309859154929577 19.2 19 2 increased bone mineral density 0.0363649109233619 0.156496652752261 1.02217493384426 0.309734513274336 19.2 19 2 abnormal B cell differentiation 0.0608694649350428 0.200546747054197 1.01543531889583 0.307692307692308 19.2 19 2 absent corpus luteum 0.132579333848246 0.353345794900289 1.01543531889583 0.307692307692308 19.2 19 2 abnormal ureter morphology 0.242818039598086 0.455856508302066 1.01543531889583 0.307692307692308 19.2 19 2 small seminal vesicle 0.242818039598086 0.455856508302066 1.01543531889583 0.307692307692308 19.2 19 2 abnormal erythrocyte osmotic lysis 0.242818039598086 0.455856508302066 1.01543531889583 0.307692307692308 19.2 19 2 pulmonary edema 0.242818039598086 0.455856508302066 1.01543531889583 0.307692307692308 19.2 19 2 increased thymocyte apoptosis 0.242818039598086 0.455856508302066 1.01543531889583 0.307692307692308 19.2 19 2 decreased urine osmolality 0.146994395262558 0.365283274940672 1.01025452645249 0.306122448979592 19.2 19 2 abnormal colon morphology 0.123354083311913 0.349522934134606 1.00682993483739 0.305084745762712 19.2 19 2 abnormal sleep pattern 0.163192852930442 0.402090727472396 1.00439797847305 0.304347826086957 19.2 19 2 conjunctivitis 0.275078092202502 0.508180350770512 1.00439797847305 0.304347826086957 19.2 19 2 pancreas inflammation 0.275078092202502 0.508180350770512 1.00439797847305 0.304347826086957 19.2 19 2 abnormal Wolffian duct morphology 0.275078092202502 0.508180350770512 1.00439797847305 0.304347826086957 19.2 19 2 decreased epididymis weight 0.275078092202502 0.508180350770512 1.00439797847305 0.304347826086957 19.2 19 2 abnormal B cell morphology 0.275078092202502 0.508180350770512 1.00439797847305 0.304347826086957 19.2 19 2 abnormal palatal shelf fusion at midline 0.275078092202502 0.508180350770512 1.00439797847305 0.304347826086957 19.2 19 2 decreased effector memory CD8-positive, alpha-beta T cell number 0.275078092202502 0.508180350770512 1.00439797847305 0.304347826086957 19.2 19 2 abnormal intestinal mucosa morphology 0.181445282086894 0.441062363238475 0.997724237752302 0.302325581395349 19.2 19 2 skin lesions 0.126577174146394 0.353345794900289 0.995287792727265 0.301587301587302 19.2 19 2 abnormal skin pigmentation 0.202076677535308 0.441062363238475 0.990049435923438 0.3 19.2 19 2 abnormal hair cycle 0.248215529381033 0.465638106587722 0.990049435923438 0.3 19.2 19 2 arrested T cell differentiation 0.248215529381033 0.465638106587722 0.990049435923438 0.3 19.2 19 2 small gonad 0.313369333918637 0.562211480795247 0.990049435923438 0.3 19.2 19 2 abnormal dopamine level 0.313369333918637 0.562211480795247 0.990049435923438 0.3 19.2 19 2 decreased myocardial infarction size 0.313369333918637 0.562211480795247 0.990049435923438 0.3 19.2 19 2 nuclear cataracts 0.313369333918637 0.562211480795247 0.990049435923438 0.3 19.2 19 2 increased T cell proliferation 0.0675578177080121 0.221409843937655 0.986965169767913 0.299065420560748 19.2 19 2 abnormal cytokine secretion 0.0346359334297655 0.152017895436771 0.985763507629397 0.298701298701299 19.2 19 2 increased macrophage cell number 0.154234728301027 0.382702131320504 0.98425967314026 0.298245614035088 19.2 19 2 decreased bone trabecula number 0.185349354670357 0.441062363238475 0.983027808718307 0.297872340425532 19.2 19 2 decreased T cell proliferation 0.040987330200464 0.160378204330247 0.981130071635839 0.297297297297297 19.2 19 2 decreased platelet aggregation 0.170469727378608 0.417160301873377 0.977826603381173 0.296296296296296 19.2 19 2 rectal prolapse 0.279654060101267 0.509439380814282 0.977826603381173 0.296296296296296 19.2 19 2 abnormal type II pneumocyte morphology 0.279654060101267 0.509439380814282 0.977826603381173 0.296296296296296 19.2 19 2 decreased susceptibility to pharmacologically induced seizures 0.279654060101267 0.509439380814282 0.977826603381173 0.296296296296296 19.2 19 2 decreased bone ossification 0.279654060101267 0.509439380814282 0.977826603381173 0.296296296296296 19.2 19 2 increased liver weight 0.103674793606566 0.302157058109352 0.975048686894295 0.295454545454545 19.2 19 2 increased T cell number 0.103674793606566 0.302157058109352 0.975048686894295 0.295454545454545 19.2 19 2 decreased macrophage cell number 0.205829445899128 0.441062363238475 0.975048686894295 0.295454545454545 19.2 19 2 decreased susceptibility to injury 0.145128135428463 0.363368129721491 0.970636701885723 0.294117647058824 19.2 19 2 lung hemorrhage 0.252144429047357 0.472118379567407 0.970636701885723 0.294117647058824 19.2 19 2 decreased pancreatic beta cell number 0.252144429047357 0.472118379567407 0.970636701885723 0.294117647058824 19.2 19 2 decreased osteoblast cell number 0.252144429047357 0.472118379567407 0.970636701885723 0.294117647058824 19.2 19 2 increased susceptibility to weight gain 0.252144429047357 0.472118379567407 0.970636701885723 0.294117647058824 19.2 19 2 abnormal skin physiology 0.252144429047357 0.472118379567407 0.970636701885723 0.294117647058824 19.2 19 2 abnormal survival 0.359585021424153 0.612131422676981 0.970636701885723 0.294117647058824 19.2 19 2 delayed heart development 0.359585021424153 0.612131422676981 0.970636701885723 0.294117647058824 19.2 19 2 thrombocytosis 0.173311983775604 0.423698830114806 0.967289678775772 0.293103448275862 19.2 19 2 abnormal response/metabolism to endogenous compounds 0.12437203962227 0.350964774316954 0.965901888705793 0.292682926829268 19.2 19 2 increased tumor growth/size 0.228910732891189 0.441062363238475 0.965901888705793 0.292682926829268 19.2 19 2 abnormal hair shaft morphology 0.208857693520191 0.441062363238475 0.962548062703342 0.291666666666667 19.2 19 2 abnormal cellular extravasation 0.316351027574856 0.566947536810126 0.962548062703342 0.291666666666667 19.2 19 2 abnormal response to infection 0.136273241922327 0.353345794900289 0.960807469461564 0.291139240506329 19.2 19 2 decreased circulating calcium level 0.191289990109708 0.441062363238475 0.960047937865152 0.290909090909091 19.2 19 2 absent mature ovarian follicles 0.282669274436216 0.514743645798014 0.958112357345262 0.290322580645161 19.2 19 2 increased percent body fat/body weight 0.21130027032936 0.441062363238475 0.951970611464844 0.288461538461538 19.2 19 2 straub tail 0.317820858865304 0.568966812830114 0.942904224688988 0.285714285714286 19.2 19 2 increased fluid intake 0.233603012823245 0.442733329065006 0.942904224688988 0.285714285714286 19.2 19 2 abnormal eye pigmentation 0.359650281102475 0.612131422676981 0.942904224688988 0.285714285714286 19.2 19 2 abnormal hematopoietic system physiology 0.359650281102475 0.612131422676981 0.942904224688988 0.285714285714286 19.2 19 2 abnormal associative learning 0.359650281102475 0.612131422676981 0.942904224688988 0.285714285714286 19.2 19 2 increased acute inflammation 0.359650281102475 0.612131422676981 0.942904224688988 0.285714285714286 19.2 19 2 teratozoospermia 0.153953936331277 0.382196024574902 0.937546814321437 0.284090909090909 19.2 19 2 abnormal T cell activation 0.181019160196724 0.441062363238475 0.936533250197847 0.283783783783784 19.2 19 2 abnormal lens fiber morphology 0.28575308277357 0.519882650604204 0.930815708987847 0.282051282051282 19.2 19 2 increased autoantibody level 0.28575308277357 0.519882650604204 0.930815708987847 0.282051282051282 19.2 19 2 abnormal lymphatic vessel morphology 0.318310343547236 0.569024060060186 0.928171346178223 0.28125 19.2 19 2 increased dopamine level 0.318310343547236 0.569024060060186 0.928171346178223 0.28125 19.2 19 2 abnormal spongiotrophoblast layer morphology 0.318310343547236 0.569024060060186 0.928171346178223 0.28125 19.2 19 2 abnormal serotonin level 0.318310343547236 0.569024060060186 0.928171346178223 0.28125 19.2 19 2 ruffled hair 0.358586592275658 0.611576378666917 0.924046140195209 0.28 19.2 19 2 increased liver glycogen level 0.358586592275658 0.611576378666917 0.924046140195209 0.28 19.2 19 2 abnormal male reproductive system morphology 0.286327833073603 0.520453405020524 0.920976219463663 0.27906976744186 19.2 19 2 impaired macrophage phagocytosis 0.286327833073603 0.520453405020524 0.920976219463663 0.27906976744186 19.2 19 2 acidosis 0.411454921445202 0.639683823184337 0.91671244066985 0.277777777777778 19.2 19 2 abnormal neutrophil morphology 0.411454921445202 0.639683823184337 0.91671244066985 0.277777777777778 19.2 19 2 increased susceptibility to autoimmune disorder 0.411454921445202 0.639683823184337 0.91671244066985 0.277777777777778 19.2 19 2 abnormal macrophage chemotaxis 0.411454921445202 0.639683823184337 0.91671244066985 0.277777777777778 19.2 19 2 increased adipocyte glucose uptake 0.411454921445202 0.639683823184337 0.91671244066985 0.277777777777778 19.2 19 2 increased systemic arterial blood pressure 0.286465656754643 0.520513748120654 0.912811536666999 0.276595744680851 19.2 19 2 increased neutrophil cell number 0.128297014211805 0.353345794900289 0.910390285906609 0.275862068965517 19.2 19 2 decreased granulocyte number 0.356877946027856 0.60993312125916 0.910390285906609 0.275862068965517 19.2 19 2 focal hair loss 0.356877946027856 0.60993312125916 0.910390285906609 0.275862068965517 19.2 19 2 abnormal food intake 0.237981997052359 0.450175070469766 0.908741028142286 0.27536231884058 19.2 19 2 abnormal female reproductive system morphology 0.317492408898428 0.568583417663672 0.907545316263151 0.275 19.2 19 2 abnormal pancreatic beta cell morphology 0.317492408898428 0.568583417663672 0.907545316263151 0.275 19.2 19 2 abnormal immune system physiology 0.160110553416699 0.396885900970641 0.904883893048303 0.274193548387097 19.2 19 2 abnormal T-helper 2 physiology 0.285804834050754 0.519882650604204 0.90004494174858 0.272727272727273 19.2 19 2 absent vibrissae 0.354782883368465 0.608426351174807 0.90004494174858 0.272727272727273 19.2 19 2 decreased systemic arterial blood pressure 0.354782883368465 0.608426351174807 0.90004494174858 0.272727272727273 19.2 19 2 abnormal T cell subpopulation ratio 0.354782883368465 0.608426351174807 0.90004494174858 0.272727272727273 19.2 19 2 abnormal long bone epiphysis morphology 0.406270114082214 0.639683823184337 0.90004494174858 0.272727272727273 19.2 19 2 abnormal enterocyte morphology 0.406270114082214 0.639683823184337 0.90004494174858 0.272727272727273 19.2 19 2 pulmonary vascular congestion 0.406270114082214 0.639683823184337 0.90004494174858 0.272727272727273 19.2 19 2 impaired humoral immune response 0.406270114082214 0.639683823184337 0.90004494174858 0.272727272727273 19.2 19 2 abnormal intestinal epithelium morphology 0.315291471670297 0.565252278039542 0.893794629653103 0.270833333333333 19.2 19 2 abnormal pancreatic beta cell physiology 0.352450639442222 0.605052426233629 0.891936428759854 0.27027027027027 19.2 19 2 abnormal leukocyte migration 0.313886080185801 0.562935561977058 0.888505904033854 0.269230769230769 19.2 19 2 abnormal stomach morphology 0.401238164314764 0.639683823184337 0.888505904033854 0.269230769230769 19.2 19 2 decreased Peyer's patch number 0.401238164314764 0.639683823184337 0.888505904033854 0.269230769230769 19.2 19 2 gastrointestinal hemorrhage 0.396391552081247 0.639683823184337 0.880043943043056 0.266666666666667 19.2 19 2 decreased eosinophil cell number 0.308979795675089 0.555137047122994 0.876606271390544 0.265625 19.2 19 2 abnormal vision 0.391732726924064 0.639683823184337 0.873573031697151 0.264705882352941 19.2 19 2 absent vitelline blood vessels 0.339503676936695 0.589128284883173 0.8684644174767 0.263157894736842 19.2 19 2 shiny skin 0.462637716083864 0.696195595135276 0.8684644174767 0.263157894736842 19.2 19 2 abnormal ear morphology 0.462637716083864 0.696195595135276 0.8684644174767 0.263157894736842 19.2 19 2 oliguria 0.462637716083864 0.696195595135276 0.8684644174767 0.263157894736842 19.2 19 2 abnormal photoreceptor inner segment morphology 0.462637716083864 0.696195595135276 0.8684644174767 0.263157894736842 19.2 19 2 abnormal behavioral response to xenobiotic 0.462637716083864 0.696195595135276 0.8684644174767 0.263157894736842 19.2 19 2 abnormal NK cell physiology 0.33686326078572 0.58475042652092 0.865616993157104 0.262295081967213 19.2 19 2 abnormal reproductive system morphology 0.382941866473358 0.639683823184337 0.864328872631573 0.261904761904762 19.2 19 2 failure of embryo implantation 0.452573180627994 0.682081664230316 0.860912552976902 0.260869565217391 19.2 19 2 abnormal digestive system physiology 0.374772955159834 0.637652343337952 0.858042844466979 0.26 19.2 19 2 abnormal T cell proliferation 0.435947126914301 0.657621878835248 0.851655428751344 0.258064516129032 19.2 19 2 abnormal intestinal goblet cell morphology 0.42881675971109 0.64706198955495 0.848613802220089 0.257142857142857 19.2 19 2 reddish skin 0.485783181430881 0.729261112739479 0.825041196602865 0.25 19.2 19 2 abnormal spleen germinal center morphology 0.485783181430881 0.729261112739479 0.825041196602865 0.25 19.2 19 2 decreased circulating progesterone level 0.485783181430881 0.729261112739479 0.825041196602865 0.25 19.2 19 2 abnormal myelopoiesis 0.449365677851356 0.677452802215301 0.825041196602865 0.25 19.2 19 2 abnormal gametogenesis 0.449365677851356 0.677452802215301 0.825041196602865 0.25 19.2 19 2 decreased metastatic potential 0.497980564979041 0.744650829807853 0.825041196602865 0.25 19.2 19 2 decreased skin tensile strength 0.512393843472272 0.756651638846707 0.825041196602865 0.25 19.2 19 2 abnormal male reproductive system physiology 0.512393843472272 0.756651638846707 0.825041196602865 0.25 19.2 19 2 dilated vasculature 0.512393843472272 0.756651638846707 0.825041196602865 0.25 19.2 19 2 arrested B cell differentiation 0.491755057282428 0.73556266084789 0.804918240588161 0.24390243902439 19.2 19 2 increased pre-B cell number 0.541999714253793 0.767105285521649 0.79203954873875 0.24 19.2 19 2 abnormal feces composition 0.541999714253793 0.767105285521649 0.79203954873875 0.24 19.2 19 2 decreased placenta weight 0.541999714253793 0.767105285521649 0.79203954873875 0.24 19.2 19 2 abnormal cytotoxic T cell physiology 0.525759179410262 0.767105285521649 0.785753520574157 0.238095238095238 19.2 19 2 increased vasoconstriction 0.560126206712834 0.781224524361186 0.785753520574157 0.238095238095238 19.2 19 2 increased keratinocyte proliferation 0.560126206712834 0.781224524361186 0.785753520574157 0.238095238095238 19.2 19 2 decreased vocalization 0.560126206712834 0.781224524361186 0.785753520574157 0.238095238095238 19.2 19 2 abnormal inflammatory response 0.517146673694137 0.763443531640454 0.779205574569372 0.236111111111111 19.2 19 2 abnormal T-helper 1 physiology 0.546821744892565 0.767105285521649 0.772378992564384 0.234042553191489 19.2 19 2 abnormal estrous cycle 0.566487549720365 0.789875437180162 0.770038450162674 0.233333333333333 19.2 19 2 abnormal humoral immune response 0.576272336127937 0.803293603876852 0.754323379751191 0.228571428571429 19.2 19 2 hypertension 0.591210695145524 0.813855342653288 0.75003745145715 0.227272727272727 19.2 19 2 increased activated T cell number 0.605377998663016 0.832436579145524 0.75003745145715 0.227272727272727 19.2 19 2 abnormal coat/ hair morphology 0.595100583628954 0.818983514122834 0.747207121451651 0.226415094339623 19.2 19 2 autoimmune response 0.604561839705467 0.831544139489826 0.745198500157426 0.225806451612903 19.2 19 2 decreased double-negative T cell number 0.604561839705467 0.831544139489826 0.745198500157426 0.225806451612903 19.2 19 2 abnormal systemic arterial blood pressure 0.622251119865348 0.852574861286177 0.73336995253588 0.222222222222222 19.2 19 2 increased susceptibility to bacterial infection induced morbidity/mortality 0.627301289095662 0.859257685366442 0.73336995253588 0.222222222222222 19.2 19 2 abnormal regulatory T cell physiology 0.647823781450523 0.859961784799371 0.717427127480752 0.217391304347826 19.2 19 2 increased susceptibility to fungal infection 0.647823781450523 0.859961784799371 0.717427127480752 0.217391304347826 19.2 19 2 abnormal vibrissa morphology 0.668571000218534 0.874149993715429 0.707178168516741 0.214285714285714 19.2 19 2 decreased sensitivity to xenobiotic induced morbidity/mortality 0.675017702961035 0.882347102530517 0.70003495469334 0.212121212121212 19.2 19 2 decreased IgA level 0.691728096010637 0.90395252893431 0.698111781740886 0.211538461538462 19.2 19 2 impaired natural killer cell mediated cytotoxicity 0.702053844042768 0.916483304674042 0.69477153398136 0.210526315789474 19.2 19 2 decreased IgG level 0.769271062166125 0.976556145515813 0.683817928715888 0.207207207207207 19.2 19 2 abnormal circulating glucose level 0.697451901845703 0.910714753722408 0.682792714429957 0.206896551724138 19.2 19 2 stomach inflammation 0.697451901845703 0.910714753722408 0.682792714429957 0.206896551724138 19.2 19 2 abnormal CD8-positive, alpha-beta T cell physiology 0.697451901845703 0.910714753722408 0.682792714429957 0.206896551724138 19.2 19 2 increased susceptibility to viral infection induced morbidity/mortality 0.70711805295876 0.922852128402369 0.679445691320006 0.205882352941176 19.2 19 2 abnormal leukocyte adhesion 0.71626778649511 0.929671859591227 0.676956879263889 0.205128205128205 19.2 19 2 abnormal respiratory system physiology 0.733157519168542 0.936541134619261 0.673503017634992 0.204081632653061 19.2 19 2 decreased inflammatory response 0.780982843313705 0.990665386406344 0.667890492488033 0.202380952380952 19.2 19 2 impaired conditioned place preference behavior 0.723570329983745 0.936541134619261 0.660032957282292 0.2 19.2 19 2 decreased monocyte cell number 0.775649935949276 0.984402661058073 0.660032957282292 0.2 19.2 19 2 abnormal pain threshold 0.730192989877038 0.936541134619261 0.660032957282292 0.2 19.2 19 2 impaired hematopoiesis 0.779601991793282 0.989166005909609 0.647091134590482 0.196078431372549 19.2 19 2 abnormal body temperature homeostasis 0.760344465918215 0.968932817096086 0.638741571563508 0.193548387096774 19.2 19 2 decreased susceptibility to bacterial infection induced morbidity/mortality 0.760344465918215 0.968932817096086 0.638741571563508 0.193548387096774 19.2 19 2 increased insulin secretion 0.790250950035631 0.996391204411695 0.624355500131898 0.189189189189189 19.2 19 2 increased susceptibility to parasitic infection 0.867151900687758 1 0.623364459655498 0.188888888888889 19.2 19 2 abnormal lymph node morphology 0.817350864031984 1 0.618780897452148 0.1875 19.2 19 2 diarrhea 0.813025182571955 1 0.60002996116572 0.181818181818182 19.2 19 2 increased susceptibility to induced arthritis 0.83821283269579 1 0.568993928691631 0.172413793103448 19.2 19 2 decreased susceptibility to induced arthritis 0.970620978638151 1 0.46318102265424 0.140350877192982 19.2 19 2 increased cardiac output 6.35423658497334e-05 0.0010900802417325 2.3458920998126 1 19.4 19 4 absent deltoid tuberosity 0.000212708884970924 0.00308520904586108 2.3458920998126 1 19.4 19 4 ductus venosus stenosis 0.000212708884970924 0.00308520904586108 2.3458920998126 1 19.4 19 4 abnormal lambdoidal suture morphology 0.000711996443347855 0.00799589685249566 2.3458920998126 1 19.4 19 4 abnormal aorta tunica adventitia morphology 0.000711996443347855 0.00799589685249566 2.3458920998126 1 19.4 19 4 increased hepatic hemangioma incidence 0.00238308736549397 0.0209838223775797 2.3458920998126 1 19.4 19 4 improved righting response 0.00238308736549397 0.0209838223775797 2.3458920998126 1 19.4 19 4 increased heart right ventricle weight 0.00238308736549397 0.0209838223775797 2.3458920998126 1 19.4 19 4 increased placenta apoptosis 0.00238308736549397 0.0209838223775797 2.3458920998126 1 19.4 19 4 decreased DN3 thymocyte number 0.00238308736549397 0.0209838223775797 2.3458920998126 1 19.4 19 4 increased Schwann cell number 0.00238308736549397 0.0209838223775797 2.3458920998126 1 19.4 19 4 trachea stenosis 0.00238308736549397 0.0209838223775797 2.3458920998126 1 19.4 19 4 decreased pre-pro B cell number 0.00238308736549397 0.0209838223775797 2.3458920998126 1 19.4 19 4 decreased small intestinal villus height 0.00238308736549397 0.0209838223775797 2.3458920998126 1 19.4 19 4 increased hemangioma incidence 1.5279231512026e-06 4.44527349545786e-05 2.17832837839742 0.928571428571429 19.4 19 4 axonal dystrophy 4.7617081002277e-06 0.000115558525846989 2.16543886136548 0.923076923076923 19.4 19 4 abnormal sphenoid bone morphology 4.54298814741705e-05 0.000824867373481745 2.13262918164782 0.909090909090909 19.4 19 4 ketoaciduria 0.000138782882585164 0.00217805943489334 2.11130288983134 0.9 19.4 19 4 lethality during fetal growth through weaning, complete penetrance 0.000138782882585164 0.00217805943489334 2.11130288983134 0.9 19.4 19 4 premature bone ossification 0.00042003609665193 0.00529032805276797 2.08523742205565 0.888888888888889 19.4 19 4 failure of vascular branching 0.00125687451881926 0.0128661537677486 2.05265558733603 0.875 19.4 19 4 absent eyelids 0.00125687451881926 0.0128661537677486 2.05265558733603 0.875 19.4 19 4 abnormal vertebral body development 0.00125687451881926 0.0128661537677486 2.05265558733603 0.875 19.4 19 4 abnormal cerebellum deep nucleus morphology 0.00125687451881926 0.0128661537677486 2.05265558733603 0.875 19.4 19 4 maxilla hypoplasia 0.00370772179360944 0.0297995410714167 2.01076465698223 0.857142857142857 19.4 19 4 abnormal oculomotor nerve morphology 0.00370772179360944 0.0297995410714167 2.01076465698223 0.857142857142857 19.4 19 4 skin photosensitivity 0.00370772179360944 0.0297995410714167 2.01076465698223 0.857142857142857 19.4 19 4 abnormal tumor incidence 0.00370772179360944 0.0297995410714167 2.01076465698223 0.857142857142857 19.4 19 4 decreased mortality induced by ionizing radiation 0.00370772179360944 0.0297995410714167 2.01076465698223 0.857142857142857 19.4 19 4 heart hemorrhage 0.00370772179360944 0.0297995410714167 2.01076465698223 0.857142857142857 19.4 19 4 decreased brain cholesterol level 0.00370772179360944 0.0297995410714167 2.01076465698223 0.857142857142857 19.4 19 4 abnormal retina inner limiting membrane morphology 0.00370772179360944 0.0297995410714167 2.01076465698223 0.857142857142857 19.4 19 4 altered tumor pathology 0.00370772179360944 0.0297995410714167 2.01076465698223 0.857142857142857 19.4 19 4 increased skin tumor incidence 5.07242954030764e-07 1.61764980532247e-05 1.99400828484071 0.85 19.4 19 4 abnormal rostral-caudal body axis extension 0.000198797689008125 0.00296113324196233 1.95491008317717 0.833333333333333 19.4 19 4 persistent right dorsal aorta 0.000198797689008125 0.00296113324196233 1.95491008317717 0.833333333333333 19.4 19 4 prenatal growth retardation 0.000198797689008125 0.00296113324196233 1.95491008317717 0.833333333333333 19.4 19 4 absent ectoplacental cone 0.0107385419762245 0.0645037451056882 1.95491008317717 0.833333333333333 19.4 19 4 delayed brain development 0.0107385419762245 0.0645037451056882 1.95491008317717 0.833333333333333 19.4 19 4 non-obstructive hydrocephaly 0.0107385419762245 0.0645037451056882 1.95491008317717 0.833333333333333 19.4 19 4 chromatolysis 0.0107385419762245 0.0645037451056882 1.95491008317717 0.833333333333333 19.4 19 4 increased post-tetanic potentiation 0.0107385419762245 0.0645037451056882 1.95491008317717 0.833333333333333 19.4 19 4 abnormal hippocampal fimbria morphology 0.0107385419762245 0.0645037451056882 1.95491008317717 0.833333333333333 19.4 19 4 ectopic thymus 0.0107385419762245 0.0645037451056882 1.95491008317717 0.833333333333333 19.4 19 4 decreased liver function 0.0107385419762245 0.0645037451056882 1.95491008317717 0.833333333333333 19.4 19 4 shortened QT interval 0.0107385419762245 0.0645037451056882 1.95491008317717 0.833333333333333 19.4 19 4 abnormal cholesterol level 0.0107385419762245 0.0645037451056882 1.95491008317717 0.833333333333333 19.4 19 4 bowed humerus 0.0107385419762245 0.0645037451056882 1.95491008317717 0.833333333333333 19.4 19 4 absent parietal bone 0.0107385419762245 0.0645037451056882 1.95491008317717 0.833333333333333 19.4 19 4 decreased prostate gland weight 0.0107385419762245 0.0645037451056882 1.95491008317717 0.833333333333333 19.4 19 4 abnormal dermis papillary layer morphology 0.0107385419762245 0.0645037451056882 1.95491008317717 0.833333333333333 19.4 19 4 delayed chorioallantoic fusion 0.0107385419762245 0.0645037451056882 1.95491008317717 0.833333333333333 19.4 19 4 abnormal neural crest cell morphology 0.0107385419762245 0.0645037451056882 1.95491008317717 0.833333333333333 19.4 19 4 abnormal orbit morphology 0.0107385419762245 0.0645037451056882 1.95491008317717 0.833333333333333 19.4 19 4 additional anastomosis between intracranial vertebral arteries 0.0107385419762245 0.0645037451056882 1.95491008317717 0.833333333333333 19.4 19 4 darkened coat color 4.10956503313529e-06 0.000103782162638823 1.95491008317717 0.833333333333333 19.4 19 4 abnormal radial glial cell morphology 0.000558871387584633 0.00663576408886288 1.91936626348304 0.818181818181818 19.4 19 4 abnormal spinal cord ventral horn morphology 0.000558871387584633 0.00663576408886288 1.91936626348304 0.818181818181818 19.4 19 4 aorta dilation 0.000558871387584633 0.00663576408886288 1.91936626348304 0.818181818181818 19.4 19 4 abnormal pulmonary alveolar sac morphology 0.000558871387584633 0.00663576408886288 1.91936626348304 0.818181818181818 19.4 19 4 increased cellular sensitivity to ionizing radiation 3.1971489325499e-07 1.10457055134971e-05 1.87671367985008 0.8 19.4 19 4 fused cornea and lens 0.00154504895291899 0.0149346877553113 1.87671367985008 0.8 19.4 19 4 increased pulmonary respiratory rate 0.000236788332525283 0.00336577701232366 1.84320093556705 0.785714285714286 19.4 19 4 multiple persisting craniopharyngeal ducts 0.000236788332525283 0.00336577701232366 1.84320093556705 0.785714285714286 19.4 19 4 increased brain weight 3.79050382856371e-07 1.30053493428306e-05 1.82458274429869 0.777777777777778 19.4 19 4 heart hyperplasia 0.00418580899640493 0.0314567972161851 1.82458274429869 0.777777777777778 19.4 19 4 synostosis 0.00418580899640493 0.0314567972161851 1.82458274429869 0.777777777777778 19.4 19 4 abnormal kindling response 0.00418580899640493 0.0314567972161851 1.82458274429869 0.777777777777778 19.4 19 4 decreased level of surface class I molecules 0.00418580899640493 0.0314567972161851 1.82458274429869 0.777777777777778 19.4 19 4 abnormal NMDA-mediated synaptic currents 0.00418580899640493 0.0314567972161851 1.82458274429869 0.777777777777778 19.4 19 4 decreased cellular sensitivity to ionizing radiation 0.00418580899640493 0.0314567972161851 1.82458274429869 0.777777777777778 19.4 19 4 small scapula 0.00418580899640493 0.0314567972161851 1.82458274429869 0.777777777777778 19.4 19 4 decreased transitional stage T1 B cell number 0.00418580899640493 0.0314567972161851 1.82458274429869 0.777777777777778 19.4 19 4 iris coloboma 0.00418580899640493 0.0314567972161851 1.82458274429869 0.777777777777778 19.4 19 4 cerebellum atrophy 0.00418580899640493 0.0314567972161851 1.82458274429869 0.777777777777778 19.4 19 4 abnormal cranial suture morphology 9.85060347137977e-05 0.00159631114886366 1.79391748809199 0.764705882352941 19.4 19 4 abnormal embryonic-extraembryonic boundary morphology 9.85060347137977e-05 0.00159631114886366 1.79391748809199 0.764705882352941 19.4 19 4 increased brain size 9.85060347137977e-05 0.00159631114886366 1.79391748809199 0.764705882352941 19.4 19 4 increased muscle cell glucose uptake 1.58048054768074e-05 0.000334591094668583 1.78734636176198 0.761904761904762 19.4 19 4 abnormal tympanic ring morphology 0.000254691044101497 0.00352949288135083 1.75941907485945 0.75 19.4 19 4 increased cochlear outer hair cell number 0.000254691044101497 0.00352949288135083 1.75941907485945 0.75 19.4 19 4 impaired somite development 0.000254691044101497 0.00352949288135083 1.75941907485945 0.75 19.4 19 4 abnormal thymus involution 0.00163909248331416 0.0154149056795613 1.75941907485945 0.75 19.4 19 4 abnormal embryonic growth/weight/body size 0.00163909248331416 0.0154149056795613 1.75941907485945 0.75 19.4 19 4 small intestinal inflammation 0.00163909248331416 0.0154149056795613 1.75941907485945 0.75 19.4 19 4 abnormal nucleotide metabolism 0.00163909248331416 0.0154149056795613 1.75941907485945 0.75 19.4 19 4 abnormal fatty acid level 0.00163909248331416 0.0154149056795613 1.75941907485945 0.75 19.4 19 4 decreased red blood cell distribution width 0.00163909248331416 0.0154149056795613 1.75941907485945 0.75 19.4 19 4 abnormal pulmonary valve cusp morphology 0.00163909248331416 0.0154149056795613 1.75941907485945 0.75 19.4 19 4 abnormal respiratory motile cilium morphology 0.00163909248331416 0.0154149056795613 1.75941907485945 0.75 19.4 19 4 abnormal exoccipital bone morphology 0.01106026361798 0.0645037451056882 1.75941907485945 0.75 19.4 19 4 poor grooming 0.01106026361798 0.0645037451056882 1.75941907485945 0.75 19.4 19 4 absent tympanic ring 0.01106026361798 0.0645037451056882 1.75941907485945 0.75 19.4 19 4 early eyelid opening 0.01106026361798 0.0645037451056882 1.75941907485945 0.75 19.4 19 4 abnormal cellular cholesterol metabolism 0.01106026361798 0.0645037451056882 1.75941907485945 0.75 19.4 19 4 colon polyps 0.01106026361798 0.0645037451056882 1.75941907485945 0.75 19.4 19 4 elevated level of mitotic sister chromatid exchange 0.01106026361798 0.0645037451056882 1.75941907485945 0.75 19.4 19 4 abnormal extraembryonic tissue physiology 0.01106026361798 0.0645037451056882 1.75941907485945 0.75 19.4 19 4 abnormal kidney epithelium morphology 0.01106026361798 0.0645037451056882 1.75941907485945 0.75 19.4 19 4 abnormal NK cell morphology 0.01106026361798 0.0645037451056882 1.75941907485945 0.75 19.4 19 4 Sertoli cell hypoplasia 0.01106026361798 0.0645037451056882 1.75941907485945 0.75 19.4 19 4 craniofacial phenotype 0.01106026361798 0.0645037451056882 1.75941907485945 0.75 19.4 19 4 abnormal sphingomyelin level 0.01106026361798 0.0645037451056882 1.75941907485945 0.75 19.4 19 4 abnormal olfactory bulb glomerular layer morphology 0.01106026361798 0.0645037451056882 1.75941907485945 0.75 19.4 19 4 abnormal olfactory bulb mitral cell layer morphology 0.01106026361798 0.0645037451056882 1.75941907485945 0.75 19.4 19 4 delayed suture closure 0.01106026361798 0.0645037451056882 1.75941907485945 0.75 19.4 19 4 abnormal stomach position or orientation 0.01106026361798 0.0645037451056882 1.75941907485945 0.75 19.4 19 4 decreased lung compliance 0.01106026361798 0.0645037451056882 1.75941907485945 0.75 19.4 19 4 lethality during fetal growth through weaning, incomplete penetrance 0.01106026361798 0.0645037451056882 1.75941907485945 0.75 19.4 19 4 increased circulating ferritin level 0.01106026361798 0.0645037451056882 1.75941907485945 0.75 19.4 19 4 abnormal heart echocardiography feature 0.01106026361798 0.0645037451056882 1.75941907485945 0.75 19.4 19 4 increased testis apoptosis 0.01106026361798 0.0645037451056882 1.75941907485945 0.75 19.4 19 4 abnormal umbilical vein topology 0.01106026361798 0.0645037451056882 1.75941907485945 0.75 19.4 19 4 abnormal brainstem morphology 1.08651633752902e-06 3.23677771209993e-05 1.75941907485945 0.75 19.4 19 4 increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 0.000103089469360839 0.00165977381899733 1.72855207354613 0.736842105263158 19.4 19 4 audiogenic seizures 0.000646865310860834 0.00743222845619549 1.72032087319591 0.733333333333333 19.4 19 4 absent egg cylinders 0.000646865310860834 0.00743222845619549 1.72032087319591 0.733333333333333 19.4 19 4 delayed intramembranous bone ossification 0.000646865310860834 0.00743222845619549 1.72032087319591 0.733333333333333 19.4 19 4 abnormal pericyte morphology 0.000646865310860834 0.00743222845619549 1.72032087319591 0.733333333333333 19.4 19 4 abnormal placenta size 0.000646865310860834 0.00743222845619549 1.72032087319591 0.733333333333333 19.4 19 4 heterochrony 0.000646865310860834 0.00743222845619549 1.72032087319591 0.733333333333333 19.4 19 4 abnormal cell differentiation 1.34381938641361e-08 6.49077810427933e-07 1.71650641449703 0.731707317073171 19.4 19 4 heart inflammation 6.87362591014503e-06 0.000162067719919296 1.71430576524767 0.730769230769231 19.4 19 4 embryonic lethality before implantation, incomplete penetrance 4.17847831857142e-05 0.000766439171147618 1.70610334531826 0.727272727272727 19.4 19 4 abnormal ear position 0.00417485579381061 0.0314567972161851 1.70610334531826 0.727272727272727 19.4 19 4 premature suture closure 0.00417485579381061 0.0314567972161851 1.70610334531826 0.727272727272727 19.4 19 4 delayed hepatic development 0.00417485579381061 0.0314567972161851 1.70610334531826 0.727272727272727 19.4 19 4 abnormal eye distance/ position 0.00417485579381061 0.0314567972161851 1.70610334531826 0.727272727272727 19.4 19 4 abnormal fear/anxiety-related behavior 0.00417485579381061 0.0314567972161851 1.70610334531826 0.727272727272727 19.4 19 4 abnormal bronchiole morphology 0.00417485579381061 0.0314567972161851 1.70610334531826 0.727272727272727 19.4 19 4 impaired luteinization 0.00417485579381061 0.0314567972161851 1.70610334531826 0.727272727272727 19.4 19 4 abnormal coronal suture morphology 0.00417485579381061 0.0314567972161851 1.70610334531826 0.727272727272727 19.4 19 4 abnormal dorsal-ventral polarity of the somites 0.00417485579381061 0.0314567972161851 1.70610334531826 0.727272727272727 19.4 19 4 abnormal palate development 0.00417485579381061 0.0314567972161851 1.70610334531826 0.727272727272727 19.4 19 4 common atrioventricular valve 0.00417485579381061 0.0314567972161851 1.70610334531826 0.727272727272727 19.4 19 4 decreased embryonic cilium length 0.00417485579381061 0.0314567972161851 1.70610334531826 0.727272727272727 19.4 19 4 increased circulating renin level 0.000257108417886457 0.00354325312738262 1.69425540542021 0.722222222222222 19.4 19 4 small thoracic cage 0.000257108417886457 0.00354325312738262 1.69425540542021 0.722222222222222 19.4 19 4 increased lactate dehydrogenase level 0.00160964945754834 0.0154000116371211 1.67563721415186 0.714285714285714 19.4 19 4 vascular smooth muscle hypoplasia 0.00160964945754834 0.0154000116371211 1.67563721415186 0.714285714285714 19.4 19 4 abnormal maternal decidual layer morphology 0.00160964945754834 0.0154000116371211 1.67563721415186 0.714285714285714 19.4 19 4 abnormal vitelline vein topology 0.00160964945754834 0.0154000116371211 1.67563721415186 0.714285714285714 19.4 19 4 failure of atrioventricular cushion closure 0.0283155924327623 0.12759970321829 1.67563721415186 0.714285714285714 19.4 19 4 decreased Schwann cell number 0.0283155924327623 0.12759970321829 1.67563721415186 0.714285714285714 19.4 19 4 abnormal lacrimal gland morphology 0.0283155924327623 0.12759970321829 1.67563721415186 0.714285714285714 19.4 19 4 excessive tearing 0.0283155924327623 0.12759970321829 1.67563721415186 0.714285714285714 19.4 19 4 limp posture 0.0283155924327623 0.12759970321829 1.67563721415186 0.714285714285714 19.4 19 4 abnormal axial mesoderm 0.0283155924327623 0.12759970321829 1.67563721415186 0.714285714285714 19.4 19 4 increased cell nucleus count 0.0283155924327623 0.12759970321829 1.67563721415186 0.714285714285714 19.4 19 4 abnormal cochlear nerve compound action potential 0.0283155924327623 0.12759970321829 1.67563721415186 0.714285714285714 19.4 19 4 atherosclerotic lesions 0.0283155924327623 0.12759970321829 1.67563721415186 0.714285714285714 19.4 19 4 enhanced behavioral response to alcohol 0.0283155924327623 0.12759970321829 1.67563721415186 0.714285714285714 19.4 19 4 abnormal sperm annulus morphology 0.0283155924327623 0.12759970321829 1.67563721415186 0.714285714285714 19.4 19 4 abnormal cerebellum white matter morphology 0.0283155924327623 0.12759970321829 1.67563721415186 0.714285714285714 19.4 19 4 decreased DN2 thymocyte number 0.0283155924327623 0.12759970321829 1.67563721415186 0.714285714285714 19.4 19 4 arteritis 0.0283155924327623 0.12759970321829 1.67563721415186 0.714285714285714 19.4 19 4 decreased skeletal muscle glycogen level 0.0283155924327623 0.12759970321829 1.67563721415186 0.714285714285714 19.4 19 4 abnormal aortic valve cusp morphology 0.0283155924327623 0.12759970321829 1.67563721415186 0.714285714285714 19.4 19 4 thick mitral valve cusps 0.0283155924327623 0.12759970321829 1.67563721415186 0.714285714285714 19.4 19 4 abnormal outer hair cell kinocilium morphology 0.0283155924327623 0.12759970321829 1.67563721415186 0.714285714285714 19.4 19 4 small tail bud 0.0283155924327623 0.12759970321829 1.67563721415186 0.714285714285714 19.4 19 4 decreased CD8-positive, naive alpha-beta T cell number 0.0283155924327623 0.12759970321829 1.67563721415186 0.714285714285714 19.4 19 4 embryo tumor 0.0283155924327623 0.12759970321829 1.67563721415186 0.714285714285714 19.4 19 4 decreased collagen level 0.0283155924327623 0.12759970321829 1.67563721415186 0.714285714285714 19.4 19 4 abnormal placenta vasculature 9.91159474811564e-10 6.16377298398442e-08 1.66919245563589 0.711538461538462 19.4 19 4 vertebral transformation 5.74203405898902e-09 3.13918894983191e-07 1.6616735707006 0.708333333333333 19.4 19 4 ocular hypertelorism 4.1311976858462e-05 0.000764041207698321 1.6616735707006 0.708333333333333 19.4 19 4 abnormal testis development 0.000629535066631974 0.00733474697071211 1.65592383516184 0.705882352941177 19.4 19 4 anencephaly 0.000248752948604991 0.00347625258233098 1.64212446986882 0.7 19.4 19 4 absent ductus venosus valve 0.000248752948604991 0.00347625258233098 1.64212446986882 0.7 19.4 19 4 acrania 0.0103475824312054 0.0640288838249342 1.64212446986882 0.7 19.4 19 4 abnormal gas homeostasis 0.0103475824312054 0.0640288838249342 1.64212446986882 0.7 19.4 19 4 abnormal plasma membrane morphology 0.0103475824312054 0.0640288838249342 1.64212446986882 0.7 19.4 19 4 abnormal corneal endothelium morphology 0.0103475824312054 0.0640288838249342 1.64212446986882 0.7 19.4 19 4 decreased thyroxine level 0.0103475824312054 0.0640288838249342 1.64212446986882 0.7 19.4 19 4 decreased transitional stage T2 B cell number 0.0103475824312054 0.0640288838249342 1.64212446986882 0.7 19.4 19 4 abnormal hippocampus neuron morphology 0.0103475824312054 0.0640288838249342 1.64212446986882 0.7 19.4 19 4 decreased circulating lactate level 0.0103475824312054 0.0640288838249342 1.64212446986882 0.7 19.4 19 4 abnormal neural tube closure 6.45085384790945e-14 7.82756046179257e-12 1.63929809384495 0.698795180722892 19.4 19 4 increased thymocyte apoptosis 3.96834966045618e-05 0.000736661923909309 1.62407914602411 0.692307692307692 19.4 19 4 absent teeth 0.00391172324221716 0.0308901954444926 1.62407914602411 0.692307692307692 19.4 19 4 absent myocardial trabeculae 0.00391172324221716 0.0308901954444926 1.62407914602411 0.692307692307692 19.4 19 4 abnormal coping response 0.00391172324221716 0.0308901954444926 1.62407914602411 0.692307692307692 19.4 19 4 muscle fatigue 0.00391172324221716 0.0308901954444926 1.62407914602411 0.692307692307692 19.4 19 4 increased cochlear inner hair cell number 0.00391172324221716 0.0308901954444926 1.62407914602411 0.692307692307692 19.4 19 4 increased prostaglandin level 0.00391172324221716 0.0308901954444926 1.62407914602411 0.692307692307692 19.4 19 4 absent hypoglossal nerve 0.00391172324221716 0.0308901954444926 1.62407914602411 0.692307692307692 19.4 19 4 spina bifida 1.86126594790521e-07 6.98747546920722e-06 1.6197826403468 0.69047619047619 19.4 19 4 short sternum 1.59750226118897e-05 0.000335340664532283 1.61785662056042 0.689655172413793 19.4 19 4 blood in lymph vessels 1.59750226118897e-05 0.000335340664532283 1.61785662056042 0.689655172413793 19.4 19 4 abnormal craniofacial morphology 3.25277278129637e-16 5.58018778860325e-14 1.61707125326888 0.689320388349515 19.4 19 4 small heart 3.12490975456894e-08 1.41331145718004e-06 1.61280081862117 0.6875 19.4 19 4 increased fibroblast apoptosis 6.45638745113909e-06 0.0001529548931877 1.61280081862117 0.6875 19.4 19 4 abnormal bone marrow cell number 0.00150964869773138 0.0147642730589567 1.61280081862117 0.6875 19.4 19 4 abnormal pulmonary elastic fiber morphology 0.00150964869773138 0.0147642730589567 1.61280081862117 0.6875 19.4 19 4 blepharitis 0.00150964869773138 0.0147642730589567 1.61280081862117 0.6875 19.4 19 4 decreased midbrain size 0.00150964869773138 0.0147642730589567 1.61280081862117 0.6875 19.4 19 4 kyphoscoliosis 0.000590816139691964 0.00693775144316853 1.60508406829283 0.684210526315789 19.4 19 4 embryonic lethality between implantation and somite formation, incomplete penetrance 0.000590816139691964 0.00693775144316853 1.60508406829283 0.684210526315789 19.4 19 4 omphalocele 1.77187172424182e-07 6.72905483061301e-06 1.59947188623587 0.681818181818182 19.4 19 4 abnormal germ layer development 0.00023356546810249 0.0033390465626721 1.59947188623587 0.681818181818182 19.4 19 4 abnormal vascular branching morphogenesis 0.00023356546810249 0.0033390465626721 1.59947188623587 0.681818181818182 19.4 19 4 abnormal cochlear sensory epithelium morphology 0.00023356546810249 0.0033390465626721 1.59947188623587 0.681818181818182 19.4 19 4 increased cellular sensitivity to gamma-irradiation 7.2491132087761e-08 3.05629984861535e-06 1.59720313178731 0.680851063829787 19.4 19 4 lymphoid hyperplasia 3.72841511420606e-05 0.000705280045367876 1.59185535344427 0.678571428571429 19.4 19 4 premature aging 3.72841511420606e-05 0.000705280045367876 1.59185535344427 0.678571428571429 19.4 19 4 subcutaneous edema 3.72841511420606e-05 0.000705280045367876 1.59185535344427 0.678571428571429 19.4 19 4 abnormal object recognition memory 1.50123229924868e-05 0.000320542089646445 1.58915271277628 0.67741935483871 19.4 19 4 myocarditis 0.00924638241480353 0.0589753237354456 1.56392806654174 0.666666666666667 19.4 19 4 interstitial pneumonia 0.00924638241480353 0.0589753237354456 1.56392806654174 0.666666666666667 19.4 19 4 increased papilloma incidence 0.00924638241480353 0.0589753237354456 1.56392806654174 0.666666666666667 19.4 19 4 stria vascularis degeneration 0.00924638241480353 0.0589753237354456 1.56392806654174 0.666666666666667 19.4 19 4 absent segment of posterior cerebral artery 0.000540647025405597 0.00652844405677874 1.56392806654174 0.666666666666667 19.4 19 4 delayed kidney development 0.00137438836412301 0.0138412593350445 1.56392806654174 0.666666666666667 19.4 19 4 abnormal metacarpal bone morphology 0.00137438836412301 0.0138412593350445 1.56392806654174 0.666666666666667 19.4 19 4 decreased cellular sensitivity to gamma-irradiation 0.00137438836412301 0.0138412593350445 1.56392806654174 0.666666666666667 19.4 19 4 abnormal eye anterior chamber morphology 0.00137438836412301 0.0138412593350445 1.56392806654174 0.666666666666667 19.4 19 4 abnormal aerobic respiration 0.00137438836412301 0.0138412593350445 1.56392806654174 0.666666666666667 19.4 19 4 abnormal olfactory nerve morphology 0.00353521775092334 0.0290226209749895 1.56392806654174 0.666666666666667 19.4 19 4 abnormal cerebral aqueduct morphology 0.00353521775092334 0.0290226209749895 1.56392806654174 0.666666666666667 19.4 19 4 abnormal aorta wall morphology 0.00353521775092334 0.0290226209749895 1.56392806654174 0.666666666666667 19.4 19 4 abnormal coronary vessel morphology 0.00353521775092334 0.0290226209749895 1.56392806654174 0.666666666666667 19.4 19 4 decreased brown adipose tissue mass 0.00353521775092334 0.0290226209749895 1.56392806654174 0.666666666666667 19.4 19 4 crypts of Lieberkuhn abscesses 0.0248091728611301 0.122446066452502 1.56392806654174 0.666666666666667 19.4 19 4 abnormal ion homeostasis 0.0248091728611301 0.122446066452502 1.56392806654174 0.666666666666667 19.4 19 4 abnormal thymus lobule morphology 0.0248091728611301 0.122446066452502 1.56392806654174 0.666666666666667 19.4 19 4 premature neuronal precursor differentiation 0.0248091728611301 0.122446066452502 1.56392806654174 0.666666666666667 19.4 19 4 decreased fear-related response 0.0248091728611301 0.122446066452502 1.56392806654174 0.666666666666667 19.4 19 4 decreased cochlear hair cell number 0.0248091728611301 0.122446066452502 1.56392806654174 0.666666666666667 19.4 19 4 increased neuronal precursor cell number 0.0248091728611301 0.122446066452502 1.56392806654174 0.666666666666667 19.4 19 4 abnormal CNS synapse formation 0.0248091728611301 0.122446066452502 1.56392806654174 0.666666666666667 19.4 19 4 abnormal intervertebral disk development 0.0248091728611301 0.122446066452502 1.56392806654174 0.666666666666667 19.4 19 4 positive geotaxis 0.0248091728611301 0.122446066452502 1.56392806654174 0.666666666666667 19.4 19 4 abnormal leukopoiesis 0.0248091728611301 0.122446066452502 1.56392806654174 0.666666666666667 19.4 19 4 increased tidal volume 0.0248091728611301 0.122446066452502 1.56392806654174 0.666666666666667 19.4 19 4 eye opacity 0.0248091728611301 0.122446066452502 1.56392806654174 0.666666666666667 19.4 19 4 abnormal cerebellar layer morphology 0.0248091728611301 0.122446066452502 1.56392806654174 0.666666666666667 19.4 19 4 axonal spheroids 0.0248091728611301 0.122446066452502 1.56392806654174 0.666666666666667 19.4 19 4 abnormal heart left ventricle pressure 0.0248091728611301 0.122446066452502 1.56392806654174 0.666666666666667 19.4 19 4 abnormal oxidative phosphorylation 0.0248091728611301 0.122446066452502 1.56392806654174 0.666666666666667 19.4 19 4 increased myeloid cell number 0.0248091728611301 0.122446066452502 1.56392806654174 0.666666666666667 19.4 19 4 abnormal infrahyoid muscle connection 0.0248091728611301 0.122446066452502 1.56392806654174 0.666666666666667 19.4 19 4 increased cardiac muscle glycogen level 0.0248091728611301 0.122446066452502 1.56392806654174 0.666666666666667 19.4 19 4 decreased brain weight 1.06805915820286e-08 5.26098446738537e-07 1.56392806654174 0.666666666666667 19.4 19 4 belly spot 1.38869599269054e-05 0.000303015901913835 1.56392806654174 0.666666666666667 19.4 19 4 abnormal astrocyte morphology 8.53967506331342e-07 2.57484142060511e-05 1.54615615669467 0.659090909090909 19.4 19 4 astrocytosis 2.61863781209288e-10 1.86110330216601e-08 1.54250439439733 0.657534246575342 19.4 19 4 scoliosis 3.13463817532412e-05 0.000613969485127461 1.53949169050202 0.65625 19.4 19 4 abnormal lumbar vertebrae morphology 3.13463817532412e-05 0.000613969485127461 1.53949169050202 0.65625 19.4 19 4 increased mortality induced by gamma-irradiation 7.77714953493858e-05 0.00129836640725904 1.5369637895324 0.655172413793103 19.4 19 4 abnormal nasal bone morphology 0.000193827004903544 0.00291326087430553 1.53385252680055 0.653846153846154 19.4 19 4 failure to gastrulate 7.77659360582977e-07 2.38818229561748e-05 1.52992963031257 0.652173913043478 19.4 19 4 abnormal hematopoietic stem cell physiology 0.000485771889881687 0.00596719790657134 1.52992963031257 0.652173913043478 19.4 19 4 abnormal vertebral artery topology 0.000485771889881687 0.00596719790657134 1.52992963031257 0.652173913043478 19.4 19 4 abnormal pericardium morphology 0.00122607635171063 0.0127609411082853 1.52482986487819 0.65 19.4 19 4 increased mammary adenocarcinoma incidence 0.00122607635171063 0.0127609411082853 1.52482986487819 0.65 19.4 19 4 spleen atrophy 0.00122607635171063 0.0127609411082853 1.52482986487819 0.65 19.4 19 4 abnormal response to tactile stimuli 0.00122607635171063 0.0127609411082853 1.52482986487819 0.65 19.4 19 4 abnormal neuron proliferation 0.00122607635171063 0.0127609411082853 1.52482986487819 0.65 19.4 19 4 malocclusion 1.14577183593553e-05 0.00025792827528413 1.52165974041899 0.648648648648649 19.4 19 4 abnormal interatrial septum morphology 0.00312319035474695 0.0265604649826771 1.51793018223169 0.647058823529412 19.4 19 4 abnormal dorsal-ventral axis patterning 0.00312319035474695 0.0265604649826771 1.51793018223169 0.647058823529412 19.4 19 4 increased regulatory T cell number 0.00312319035474695 0.0265604649826771 1.51793018223169 0.647058823529412 19.4 19 4 preaxial polydactyly 6.97222996283456e-05 0.00118385133327993 1.51347877407265 0.645161290322581 19.4 19 4 abnormal cell cycle 2.24921402092003e-14 3.02428101461545e-12 1.50953056857507 0.643478260869565 19.4 19 4 shortened head 0.000172879351147148 0.00263826617164743 1.50807349273667 0.642857142857143 19.4 19 4 absent corpus callosum 0.000172879351147148 0.00263826617164743 1.50807349273667 0.642857142857143 19.4 19 4 abnormal kidney blood vessel morphology 0.00805545605462105 0.0524553584708635 1.50807349273667 0.642857142857143 19.4 19 4 irregularly shaped pupil 0.00805545605462105 0.0524553584708635 1.50807349273667 0.642857142857143 19.4 19 4 intestinal obstruction 0.00805545605462105 0.0524553584708635 1.50807349273667 0.642857142857143 19.4 19 4 abnormal vascular endothelial cell migration 0.00805545605462105 0.0524553584708635 1.50807349273667 0.642857142857143 19.4 19 4 split sternum 0.00805545605462105 0.0524553584708635 1.50807349273667 0.642857142857143 19.4 19 4 lysosomal protein accumulation 0.00805545605462105 0.0524553584708635 1.50807349273667 0.642857142857143 19.4 19 4 spina bifida occulta 0.00805545605462105 0.0524553584708635 1.50807349273667 0.642857142857143 19.4 19 4 sternebra fusion 0.00805545605462105 0.0524553584708635 1.50807349273667 0.642857142857143 19.4 19 4 pulmonary alveolar hemorrhage 0.00805545605462105 0.0524553584708635 1.50807349273667 0.642857142857143 19.4 19 4 testis degeneration 0.00805545605462105 0.0524553584708635 1.50807349273667 0.642857142857143 19.4 19 4 increased embryonic tissue cell apoptosis 4.32231834012415e-10 2.90588293812401e-08 1.50377698705936 0.641025641025641 19.4 19 4 abnormal thyroid gland morphology 0.000430544506200599 0.00539536251473043 1.50137094388007 0.64 19.4 19 4 abnormal cochlear outer hair cell morphology 0.000430544506200599 0.00539536251473043 1.50137094388007 0.64 19.4 19 4 abnormal basisphenoid bone morphology 0.00107803975068603 0.011459931110391 1.49284042715348 0.636363636363636 19.4 19 4 aphakia 0.00107803975068603 0.011459931110391 1.49284042715348 0.636363636363636 19.4 19 4 abnormal limb posture 0.00107803975068603 0.011459931110391 1.49284042715348 0.636363636363636 19.4 19 4 increased circulating creatine kinase level 0.00107803975068603 0.011459931110391 1.49284042715348 0.636363636363636 19.4 19 4 abnormal stomach epithelium morphology 0.0211498540466464 0.108251567779903 1.49284042715348 0.636363636363636 19.4 19 4 impaired myelopoiesis 0.0211498540466464 0.108251567779903 1.49284042715348 0.636363636363636 19.4 19 4 abnormal proximal-distal axis patterning 0.0211498540466464 0.108251567779903 1.49284042715348 0.636363636363636 19.4 19 4 vasculitis 0.0211498540466464 0.108251567779903 1.49284042715348 0.636363636363636 19.4 19 4 fused joints 0.0211498540466464 0.108251567779903 1.49284042715348 0.636363636363636 19.4 19 4 enlarged pericardium 6.19003699493294e-05 0.00106558595327998 1.49284042715348 0.636363636363636 19.4 19 4 liver hypoplasia 5.62381298327472e-07 1.75965217558439e-05 1.48873921718877 0.634615384615385 19.4 19 4 oxidative stress 5.38092919047767e-11 4.53730893603838e-09 1.48573166321465 0.633333333333333 19.4 19 4 decreased cell proliferation 5.93195377302385e-21 1.8444668762996e-18 1.48361824690851 0.632432432432432 19.4 19 4 abnormal cell morphology 2.02418150672987e-13 2.39769118951931e-11 1.48161606303954 0.631578947368421 19.4 19 4 abnormal craniofacial bone morphology 2.063916538864e-07 7.54998880944735e-06 1.48161606303954 0.631578947368421 19.4 19 4 decreased total retina thickness 2.22771145302259e-05 0.000448698966752526 1.48161606303954 0.631578947368421 19.4 19 4 decreased liver regeneration 0.00271765503457623 0.0234321209653669 1.48161606303954 0.631578947368421 19.4 19 4 decreased circulating magnesium level 0.00271765503457623 0.0234321209653669 1.48161606303954 0.631578947368421 19.4 19 4 abnormal myelin sheath morphology 3.31287718518197e-06 8.58414791472933e-05 1.47893197596882 0.630434782608696 19.4 19 4 abnormal apoptosis 4.98956342279739e-07 1.60148890505916e-05 1.47704317395608 0.62962962962963 19.4 19 4 neurodegeneration 4.98956342279739e-07 1.60148890505916e-05 1.47704317395608 0.62962962962963 19.4 19 4 decreased tumor growth/size 4.98956342279739e-07 1.60148890505916e-05 1.47704317395608 0.62962962962963 19.4 19 4 thick interventricular septum 0.000377624199152122 0.00485447129400983 1.47704317395608 0.62962962962963 19.4 19 4 abnormal dermal layer morphology 5.4519025041488e-05 0.000948364159375534 1.47456074845364 0.628571428571429 19.4 19 4 abnormal artery morphology 5.4519025041488e-05 0.000948364159375534 1.47456074845364 0.628571428571429 19.4 19 4 abnormal hippocampus pyramidal cell morphology 5.4519025041488e-05 0.000948364159375534 1.47456074845364 0.628571428571429 19.4 19 4 abnormal double-strand DNA break repair 8.05134031668526e-06 0.000187174850820136 1.4730020161614 0.627906976744186 19.4 19 4 small spleen 1.02062022489809e-10 8.05965971248889e-09 1.46940494164086 0.626373626373626 19.4 19 4 abnormal forebrain development 1.02683566790504e-08 5.10850744782759e-07 1.46618256238288 0.625 19.4 19 4 bradykinesia 0.000133682162753519 0.00211132939586907 1.46618256238288 0.625 19.4 19 4 abnormal nursing 0.000937821413444778 0.0102317138857188 1.46618256238288 0.625 19.4 19 4 vasculature congestion 0.00691116617290996 0.0482230739273872 1.46618256238288 0.625 19.4 19 4 abnormal mouth morphology 0.00691116617290996 0.0482230739273872 1.46618256238288 0.625 19.4 19 4 disorganized yolk sac vascular plexus 0.00691116617290996 0.0482230739273872 1.46618256238288 0.625 19.4 19 4 intraventricular hemorrhage 0.00691116617290996 0.0482230739273872 1.46618256238288 0.625 19.4 19 4 increased pancreatic beta cell number 0.00691116617290996 0.0482230739273872 1.46618256238288 0.625 19.4 19 4 kidney degeneration 0.00691116617290996 0.0482230739273872 1.46618256238288 0.625 19.4 19 4 abnormal thoracic cage shape 0.00691116617290996 0.0482230739273872 1.46618256238288 0.625 19.4 19 4 absent pre-B cells 0.0570744737907329 0.213492862487892 1.46618256238288 0.625 19.4 19 4 pointed snout 0.0570744737907329 0.213492862487892 1.46618256238288 0.625 19.4 19 4 abnormal cecum morphology 0.0570744737907329 0.213492862487892 1.46618256238288 0.625 19.4 19 4 enlarged pituitary gland 0.0570744737907329 0.213492862487892 1.46618256238288 0.625 19.4 19 4 abnormal hypoglossal nerve morphology 0.0570744737907329 0.213492862487892 1.46618256238288 0.625 19.4 19 4 increased sensitivity to skin irradiation 0.0570744737907329 0.213492862487892 1.46618256238288 0.625 19.4 19 4 abnormal urination 0.0570744737907329 0.213492862487892 1.46618256238288 0.625 19.4 19 4 abnormal atrial thrombosis 0.0570744737907329 0.213492862487892 1.46618256238288 0.625 19.4 19 4 abnormal thyroid physiology 0.0570744737907329 0.213492862487892 1.46618256238288 0.625 19.4 19 4 decreased aerobic running capacity 0.0570744737907329 0.213492862487892 1.46618256238288 0.625 19.4 19 4 hypospadia 0.0570744737907329 0.213492862487892 1.46618256238288 0.625 19.4 19 4 abnormal soft palate morphology 0.0570744737907329 0.213492862487892 1.46618256238288 0.625 19.4 19 4 calcified muscle 0.0570744737907329 0.213492862487892 1.46618256238288 0.625 19.4 19 4 decreased susceptibility to age related obesity 0.0570744737907329 0.213492862487892 1.46618256238288 0.625 19.4 19 4 abnormal eyelid aperture 0.0570744737907329 0.213492862487892 1.46618256238288 0.625 19.4 19 4 tau protein deposits 0.0570744737907329 0.213492862487892 1.46618256238288 0.625 19.4 19 4 long femur 0.0570744737907329 0.213492862487892 1.46618256238288 0.625 19.4 19 4 small frontal bone 0.0570744737907329 0.213492862487892 1.46618256238288 0.625 19.4 19 4 absent interparietal bone 0.0570744737907329 0.213492862487892 1.46618256238288 0.625 19.4 19 4 ocular hypertension 0.0570744737907329 0.213492862487892 1.46618256238288 0.625 19.4 19 4 increased pulmonary ventilation 0.0570744737907329 0.213492862487892 1.46618256238288 0.625 19.4 19 4 abnormal epidermal lamellar body morphology 0.0570744737907329 0.213492862487892 1.46618256238288 0.625 19.4 19 4 skin fibrosis 0.0570744737907329 0.213492862487892 1.46618256238288 0.625 19.4 19 4 abnormal brain ependyma morphology 0.0570744737907329 0.213492862487892 1.46618256238288 0.625 19.4 19 4 pleural effusion 0.0570744737907329 0.213492862487892 1.46618256238288 0.625 19.4 19 4 abnormal hepatic vein morphology 0.0570744737907329 0.213492862487892 1.46618256238288 0.625 19.4 19 4 abnormal visual evoked potential 0.0570744737907329 0.213492862487892 1.46618256238288 0.625 19.4 19 4 impaired mucociliary clearance 0.0570744737907329 0.213492862487892 1.46618256238288 0.625 19.4 19 4 lung situs inversus 0.0570744737907329 0.213492862487892 1.46618256238288 0.625 19.4 19 4 abnormal foramen magnum morphology 0.0570744737907329 0.213492862487892 1.46618256238288 0.625 19.4 19 4 increased aorta wall thickness 0.0570744737907329 0.213492862487892 1.46618256238288 0.625 19.4 19 4 increased cardiac stroke volume 0.0570744737907329 0.213492862487892 1.46618256238288 0.625 19.4 19 4 absent hypoglossal canal 0.0570744737907329 0.213492862487892 1.46618256238288 0.625 19.4 19 4 increased brain apoptosis 0.0570744737907329 0.213492862487892 1.46618256238288 0.625 19.4 19 4 abnormal breathing pattern 4.77009842789171e-05 0.000853641715063354 1.45825725123486 0.621621621621622 19.4 19 4 abnormal embryonic neuroepithelium morphology 3.87428320893751e-07 1.31119448737851e-05 1.45607095850438 0.620689655172414 19.4 19 4 absent long term depression 0.000328510387907123 0.00432616453275952 1.45607095850438 0.620689655172414 19.4 19 4 gliosis 1.41598329038231e-07 5.50352880441561e-06 1.45221891893161 0.619047619047619 19.4 19 4 abnormal salivary gland morphology 0.0023398990069563 0.0209370459705173 1.45221891893161 0.619047619047619 19.4 19 4 left pulmonary isomerism 0.0023398990069563 0.0209370459705173 1.45221891893161 0.619047619047619 19.4 19 4 decreased cochlear outer hair cell number 0.0023398990069563 0.0209370459705173 1.45221891893161 0.619047619047619 19.4 19 4 embryonic lethality at implantation, complete penetrance 0.0023398990069563 0.0209370459705173 1.45221891893161 0.619047619047619 19.4 19 4 overexpanded pulmonary alveoli 0.000116305280546708 0.00185454734205087 1.44893335576661 0.617647058823529 19.4 19 4 impaired synaptic plasticity 0.000116305280546708 0.00185454734205087 1.44893335576661 0.617647058823529 19.4 19 4 decreased bone marrow cell number 1.90142608271283e-08 8.84074276775359e-07 1.4460978697475 0.616438356164384 19.4 19 4 embryonic lethality between implantation and somite formation, complete penetrance 6.53233079214329e-25 2.70819547424274e-22 1.44583553906818 0.616326530612245 19.4 19 4 kinked neural tube 2.23785784278199e-06 6.15101810377923e-05 1.44362590757699 0.615384615384615 19.4 19 4 abnormal Mullerian duct morphology 0.000809292508275889 0.00896710518635311 1.44362590757699 0.615384615384615 19.4 19 4 short premaxilla 0.0177818370909417 0.0948174057100055 1.44362590757699 0.615384615384615 19.4 19 4 abnormal pulmonary alveolus epithelial cell morphology 0.0177818370909417 0.0948174057100055 1.44362590757699 0.615384615384615 19.4 19 4 abnormal soleus morphology 0.0177818370909417 0.0948174057100055 1.44362590757699 0.615384615384615 19.4 19 4 small interparietal bone 0.0177818370909417 0.0948174057100055 1.44362590757699 0.615384615384615 19.4 19 4 abnormal vertebral arch development 0.0177818370909417 0.0948174057100055 1.44362590757699 0.615384615384615 19.4 19 4 embryonic lethality, complete penetrance 1.20323408150676e-31 6.65121061721791e-29 1.44136317104474 0.614420062695925 19.4 19 4 increased hepatocellular carcinoma incidence 8.13197750634012e-07 2.46686512768549e-05 1.44046006128844 0.614035087719298 19.4 19 4 abnormal facial morphology 8.13197750634012e-07 2.46686512768549e-05 1.44046006128844 0.614035087719298 19.4 19 4 abnormal eyelid morphology 0.000283930959796479 0.00381772033780401 1.43780483536902 0.612903225806452 19.4 19 4 abnormal postnatal growth/weight/body size 0.000283930959796479 0.00381772033780401 1.43780483536902 0.612903225806452 19.4 19 4 abnormal cell adhesion 1.94761468557596e-06 5.47422771793244e-05 1.43360072766326 0.611111111111111 19.4 19 4 abnormal megakaryocyte differentiation 0.00587130776858455 0.0420284261132491 1.43360072766326 0.611111111111111 19.4 19 4 abnormal mitral valve morphology 0.00587130776858455 0.0420284261132491 1.43360072766326 0.611111111111111 19.4 19 4 thick dermal layer 0.00587130776858455 0.0420284261132491 1.43360072766326 0.611111111111111 19.4 19 4 abnormal bile duct morphology 0.00587130776858455 0.0420284261132491 1.43360072766326 0.611111111111111 19.4 19 4 jerky movement 0.00587130776858455 0.0420284261132491 1.43360072766326 0.611111111111111 19.4 19 4 increased effector memory CD4-positive, alpha-beta T cell number 0.00587130776858455 0.0420284261132491 1.43360072766326 0.611111111111111 19.4 19 4 abnormal hypoglossal nerve topology 0.00587130776858455 0.0420284261132491 1.43360072766326 0.611111111111111 19.4 19 4 ataxia 6.14722099526458e-20 1.69902358063563e-17 1.42843924889579 0.608910891089109 19.4 19 4 abnormal cell death 1.29143819291736e-05 0.000284861404093323 1.42793432162506 0.608695652173913 19.4 19 4 embryonic lethality between implantation and placentation, complete penetrance 1.29143819291736e-05 0.000284861404093323 1.42793432162506 0.608695652173913 19.4 19 4 fragile skeleton 0.00199934531193723 0.0184198943090513 1.42793432162506 0.608695652173913 19.4 19 4 abnormal extraembryonic tissue morphology 9.77598963619252e-11 7.84444329678351e-09 1.42593441361158 0.607843137254902 19.4 19 4 abnormal response to novel object 4.66199714319666e-06 0.00011369331268335 1.42593441361158 0.607843137254902 19.4 19 4 small lung 4.66199714319666e-06 0.00011369331268335 1.42593441361158 0.607843137254902 19.4 19 4 failure of chorioallantoic fusion 4.66199714319666e-06 0.00011369331268335 1.42593441361158 0.607843137254902 19.4 19 4 abnormal dendritic spine morphology 4.66199714319666e-06 0.00011369331268335 1.42593441361158 0.607843137254902 19.4 19 4 abnormal placenta morphology 1.26323909753622e-08 6.16138677474772e-07 1.42535216191146 0.607594936708861 19.4 19 4 abnormal ovulation 0.000694048055159806 0.00784747516913644 1.42429163202908 0.607142857142857 19.4 19 4 straub tail 0.000694048055159806 0.00784747516913644 1.42429163202908 0.607142857142857 19.4 19 4 prolonged QRS complex duration 0.000694048055159806 0.00784747516913644 1.42429163202908 0.607142857142857 19.4 19 4 anophthalmia 1.70403611164979e-09 1.03385117749484e-07 1.42335026280765 0.606741573033708 19.4 19 4 abnormal vascular development 2.238457957672e-07 7.95452024244156e-06 1.42175278776521 0.606060606060606 19.4 19 4 increased cardiomyocyte apoptosis 0.000244115690144582 0.00345021465474231 1.42175278776521 0.606060606060606 19.4 19 4 incomplete somite formation 8.66842512269106e-05 0.00143273803938166 1.41988206041289 0.605263157894737 19.4 19 4 abnormal vasculogenesis 3.10038974504484e-05 0.000612080911968178 1.4184463859332 0.604651162790698 19.4 19 4 overriding aortic valve 1.11516021474148e-05 0.000252178275833584 1.41730981030345 0.604166666666667 19.4 19 4 curly tail 1.11516021474148e-05 0.000252178275833584 1.41730981030345 0.604166666666667 19.4 19 4 pale yolk sac 9.5083717431246e-09 4.87671643526236e-07 1.4131880119353 0.602409638554217 19.4 19 4 abnormal embryo size 2.36567655512076e-11 2.17948904846773e-09 1.41168728130316 0.601769911504425 19.4 19 4 short stride length 9.59935443152129e-06 0.000219067836223938 1.40753525988756 0.6 19.4 19 4 cardiomyopathy 2.66509045519131e-05 0.00053248293231232 1.40753525988756 0.6 19.4 19 4 abnormal egg cylinder morphology 0.00169873677431105 0.0158857433311982 1.40753525988756 0.6 19.4 19 4 abnormal keratinocyte physiology 0.00169873677431105 0.0158857433311982 1.40753525988756 0.6 19.4 19 4 kyphosis 1.93125659966743e-14 2.66888932870707e-12 1.40753525988756 0.6 19.4 19 4 abnormal erythropoiesis 1.50671257400796e-10 1.10233750818965e-08 1.40753525988756 0.6 19.4 19 4 embryonic lethality between somite formation and embryo turning, complete penetrance 1.67407139489585e-07 6.40654245354373e-06 1.40753525988756 0.6 19.4 19 4 thick pulmonary interalveolar septum 0.000208984663804536 0.00304896980184038 1.40753525988756 0.6 19.4 19 4 ovary cysts 0.000208984663804536 0.00304896980184038 1.40753525988756 0.6 19.4 19 4 abnormal midbrain development 0.000208984663804536 0.00304896980184038 1.40753525988756 0.6 19.4 19 4 decreased glycogen level 0.000208984663804536 0.00304896980184038 1.40753525988756 0.6 19.4 19 4 decreased bone volume 0.000208984663804536 0.00304896980184038 1.40753525988756 0.6 19.4 19 4 abnormal microglial cell physiology 0.000592313298292179 0.00693775144316853 1.40753525988756 0.6 19.4 19 4 abnormal cellular respiration 0.000592313298292179 0.00693775144316853 1.40753525988756 0.6 19.4 19 4 small gonad 0.00495502305887459 0.0363587606458718 1.40753525988756 0.6 19.4 19 4 decreased myocardial infarction size 0.00495502305887459 0.0363587606458718 1.40753525988756 0.6 19.4 19 4 abnormal induced retinal neovascularization 0.00495502305887459 0.0363587606458718 1.40753525988756 0.6 19.4 19 4 abnormal sperm mitochondrial sheath morphology 0.00495502305887459 0.0363587606458718 1.40753525988756 0.6 19.4 19 4 absent incisors 0.0148358135101676 0.0817366248206909 1.40753525988756 0.6 19.4 19 4 macrocytosis 0.0148358135101676 0.0817366248206909 1.40753525988756 0.6 19.4 19 4 abnormal cricoid cartilage morphology 0.0148358135101676 0.0817366248206909 1.40753525988756 0.6 19.4 19 4 increased alcohol consumption 0.0148358135101676 0.0817366248206909 1.40753525988756 0.6 19.4 19 4 decreased thymocyte apoptosis 0.0148358135101676 0.0817366248206909 1.40753525988756 0.6 19.4 19 4 bicuspid aortic valve 0.0148358135101676 0.0817366248206909 1.40753525988756 0.6 19.4 19 4 abnormal branching involved in lung morphogenesis 0.0148358135101676 0.0817366248206909 1.40753525988756 0.6 19.4 19 4 absent maxillary shelf 0.0465015585060169 0.183776264448681 1.40753525988756 0.6 19.4 19 4 absent palatine bone horizontal plate 0.0465015585060169 0.183776264448681 1.40753525988756 0.6 19.4 19 4 increased cranium width 0.0465015585060169 0.183776264448681 1.40753525988756 0.6 19.4 19 4 absent trophoblast giant cells 0.0465015585060169 0.183776264448681 1.40753525988756 0.6 19.4 19 4 rhinitis 0.0465015585060169 0.183776264448681 1.40753525988756 0.6 19.4 19 4 alcohol preference 0.0465015585060169 0.183776264448681 1.40753525988756 0.6 19.4 19 4 abnormal respiratory mechanics 0.0465015585060169 0.183776264448681 1.40753525988756 0.6 19.4 19 4 impaired basement membrane formation 0.0465015585060169 0.183776264448681 1.40753525988756 0.6 19.4 19 4 peritoneal inflammation 0.0465015585060169 0.183776264448681 1.40753525988756 0.6 19.4 19 4 abnormal glial cell physiology 0.0465015585060169 0.183776264448681 1.40753525988756 0.6 19.4 19 4 abnormal reproductive system development 0.0465015585060169 0.183776264448681 1.40753525988756 0.6 19.4 19 4 increased susceptibility to atherosclerosis 0.0465015585060169 0.183776264448681 1.40753525988756 0.6 19.4 19 4 osteosclerosis 0.0465015585060169 0.183776264448681 1.40753525988756 0.6 19.4 19 4 abnormal spinal cord dorsal column morphology 0.0465015585060169 0.183776264448681 1.40753525988756 0.6 19.4 19 4 increased circulating fructosamine level 0.0465015585060169 0.183776264448681 1.40753525988756 0.6 19.4 19 4 thin ventricle myocardium compact layer 0.0465015585060169 0.183776264448681 1.40753525988756 0.6 19.4 19 4 fusion of atlas and odontoid process 0.0465015585060169 0.183776264448681 1.40753525988756 0.6 19.4 19 4 abnormal pulmonary interalveolar septum morphology 0.0465015585060169 0.183776264448681 1.40753525988756 0.6 19.4 19 4 decreased trabecular bone connectivity density 0.0465015585060169 0.183776264448681 1.40753525988756 0.6 19.4 19 4 abnormal adaptive thermogenesis 0.0465015585060169 0.183776264448681 1.40753525988756 0.6 19.4 19 4 increased fatty acid oxidation 0.0465015585060169 0.183776264448681 1.40753525988756 0.6 19.4 19 4 hydrops fetalis 1.44304325147625e-07 5.56522494270877e-06 1.40101889294364 0.597222222222222 19.4 19 4 abnormal eye morphology 2.85775543030713e-13 3.23121210585863e-11 1.40078449125501 0.597122302158273 19.4 19 4 abnormal cell nucleus morphology 2.28409776255153e-05 0.000458201063253784 1.39755274031389 0.595744680851064 19.4 19 4 abnormal angiogenesis 1.24151525440688e-07 4.90201459577321e-06 1.39485476205074 0.594594594594595 19.4 19 4 kidney cortex cysts 0.000503525355474651 0.00612478885937993 1.39287343426373 0.59375 19.4 19 4 abnormal embryonic hematopoiesis 0.000503525355474651 0.00612478885937993 1.39287343426373 0.59375 19.4 19 4 abnormal thoracic vertebrae morphology 2.55973539864016e-06 6.883612761208e-05 1.39163090666849 0.593220338983051 19.4 19 4 decreased heart weight 3.90763699140414e-08 1.75139585875996e-06 1.39015828137043 0.592592592592593 19.4 19 4 axon degeneration 7.05683357398385e-06 0.000165602580332876 1.39015828137043 0.592592592592593 19.4 19 4 abnormal atrioventricular cushion morphology 0.00143717368518319 0.0142574947703554 1.39015828137043 0.592592592592593 19.4 19 4 abnormal eye muscle morphology 0.00143717368518319 0.0142574947703554 1.39015828137043 0.592592592592593 19.4 19 4 lethality throughout fetal growth and development, incomplete penetrance 3.51839001320319e-16 5.83466343856196e-14 1.38918750044769 0.592178770949721 19.4 19 4 increased T cell derived lymphoma incidence 1.95250541813556e-05 0.000396478141029568 1.38838512029726 0.591836734693878 19.4 19 4 abnormal craniofacial development 1.95250541813556e-05 0.000396478141029568 1.38838512029726 0.591836734693878 19.4 19 4 osteoporosis 5.42616817655469e-05 0.000948364159375534 1.38620896807108 0.590909090909091 19.4 19 4 decreased blood urea nitrogen level 5.42616817655469e-05 0.000948364159375534 1.38620896807108 0.590909090909091 19.4 19 4 abnormal abdominal fat pad morphology 0.00416258459934672 0.0314567972161851 1.38620896807108 0.590909090909091 19.4 19 4 abnormal tail movements 0.00416258459934672 0.0314567972161851 1.38620896807108 0.590909090909091 19.4 19 4 abnormal retinal layer morphology 0.00416258459934672 0.0314567972161851 1.38620896807108 0.590909090909091 19.4 19 4 abnormal basement membrane morphology 0.00416258459934672 0.0314567972161851 1.38620896807108 0.590909090909091 19.4 19 4 abnormal occipital bone morphology 0.00416258459934672 0.0314567972161851 1.38620896807108 0.590909090909091 19.4 19 4 abnormal iris morphology 0.000151629998924051 0.00235273400767216 1.38347482809461 0.58974358974359 19.4 19 4 failure of heart looping 0.000151629998924051 0.00235273400767216 1.38347482809461 0.58974358974359 19.4 19 4 pallor 1.63087316886449e-15 2.53549812971901e-13 1.38072506446113 0.588571428571429 19.4 19 4 ventricular septal defect 2.30518301714661e-12 2.44006074687328e-10 1.37993652930153 0.588235294117647 19.4 19 4 abnormal bone marrow cavity morphology 0.0123225601988572 0.0705463026344239 1.37993652930153 0.588235294117647 19.4 19 4 abnormal glutamate-mediated receptor currents 0.0123225601988572 0.0705463026344239 1.37993652930153 0.588235294117647 19.4 19 4 absence seizures 0.0123225601988572 0.0705463026344239 1.37993652930153 0.588235294117647 19.4 19 4 decreased birth body size 1.43561649843607e-10 1.06599881786858e-08 1.37872605866179 0.587719298245614 19.4 19 4 abnormal locomotor behavior 9.05056552609563e-09 4.73963826235008e-07 1.37693666728131 0.58695652173913 19.4 19 4 delayed bone ossification 2.13485050863754e-07 7.64092178451207e-06 1.37625669855673 0.586666666666667 19.4 19 4 abnormal neurocranium morphology 2.13485050863754e-07 7.64092178451207e-06 1.37625669855673 0.586666666666667 19.4 19 4 abnormal neural tube morphology 2.74598839991365e-14 3.595076918308e-12 1.37567746593949 0.58641975308642 19.4 19 4 prenatal lethality, complete penetrance 1.95720862641554e-23 7.49008685878255e-21 1.37546910888293 0.586330935251799 19.4 19 4 decreased trophoblast giant cell number 0.00121189308376777 0.0127466555850839 1.37517812747635 0.586206896551724 19.4 19 4 abnormal embryonic erythropoiesis 0.00121189308376777 0.0127466555850839 1.37517812747635 0.586206896551724 19.4 19 4 embryonic lethality before implantation, complete penetrance 3.33710278144823e-11 2.91264672591315e-09 1.37000098629056 0.584 19.4 19 4 embryonic lethality during organogenesis, complete penetrance 3.86147565908182e-45 4.80271035098301e-42 1.36983342256915 0.583928571428571 19.4 19 4 abnormal brain morphology 5.43595700339311e-14 6.93432976714891e-12 1.36965128808935 0.583850931677019 19.4 19 4 decreased embryo size 1.2458206810676e-38 8.85422555473047e-36 1.36925501223372 0.583682008368201 19.4 19 4 abnormal malleus morphology 0.00348547876982665 0.0288523408983155 1.36843705822402 0.583333333333333 19.4 19 4 abnormal tumor morphology 0.00348547876982665 0.0288523408983155 1.36843705822402 0.583333333333333 19.4 19 4 hypopigmentation 0.00348547876982665 0.0288523408983155 1.36843705822402 0.583333333333333 19.4 19 4 abnormal lung saccule morphology 0.00348547876982665 0.0288523408983155 1.36843705822402 0.583333333333333 19.4 19 4 abnormal supraoccipital bone morphology 0.0378147143312265 0.156252660961671 1.36843705822402 0.583333333333333 19.4 19 4 abnormal rectum morphology 0.0378147143312265 0.156252660961671 1.36843705822402 0.583333333333333 19.4 19 4 mesocardia 0.0378147143312265 0.156252660961671 1.36843705822402 0.583333333333333 19.4 19 4 impaired embryo implantation 0.0378147143312265 0.156252660961671 1.36843705822402 0.583333333333333 19.4 19 4 abnormal corticospinal tract morphology 0.0378147143312265 0.156252660961671 1.36843705822402 0.583333333333333 19.4 19 4 abnormal AMPA-mediated synaptic currents 0.0378147143312265 0.156252660961671 1.36843705822402 0.583333333333333 19.4 19 4 decreased synaptic depression 0.0378147143312265 0.156252660961671 1.36843705822402 0.583333333333333 19.4 19 4 abnormal gastrocnemius morphology 0.0378147143312265 0.156252660961671 1.36843705822402 0.583333333333333 19.4 19 4 abnormal alisphenoid bone morphology 0.0378147143312265 0.156252660961671 1.36843705822402 0.583333333333333 19.4 19 4 loss of dopaminergic neurons 0.0378147143312265 0.156252660961671 1.36843705822402 0.583333333333333 19.4 19 4 pale placenta 0.0378147143312265 0.156252660961671 1.36843705822402 0.583333333333333 19.4 19 4 hematuria 0.0378147143312265 0.156252660961671 1.36843705822402 0.583333333333333 19.4 19 4 decreased prostaglandin level 0.0378147143312265 0.156252660961671 1.36843705822402 0.583333333333333 19.4 19 4 increased fibrosarcoma incidence 0.0378147143312265 0.156252660961671 1.36843705822402 0.583333333333333 19.4 19 4 embryonic lethality between implantation and placentation, incomplete penetrance 0.0378147143312265 0.156252660961671 1.36843705822402 0.583333333333333 19.4 19 4 abnormal vitelline vein connection 0.0378147143312265 0.156252660961671 1.36843705822402 0.583333333333333 19.4 19 4 abnormal lysosome morphology 0.000360671753380831 0.00466062850147957 1.36843705822402 0.583333333333333 19.4 19 4 abnormal homeostasis 0.000108915405298961 0.00174791658503977 1.363890755705 0.581395348837209 19.4 19 4 increased granulocyte number 4.23670130390251e-07 1.40517259912767e-05 1.36315351745868 0.581081081081081 19.4 19 4 abnormal embryo development 7.72671416313649e-12 7.61387400614021e-10 1.36268732268526 0.580882352941177 19.4 19 4 prenatal lethality 3.72257981460155e-06 9.44889519267485e-05 1.36213089666538 0.580645161290323 19.4 19 4 pale kidney 0.00101930422851699 0.011023996819287 1.36213089666538 0.580645161290323 19.4 19 4 abnormal mitochondrial ATP synthesis coupled electron transport 0.00101930422851699 0.011023996819287 1.36213089666538 0.580645161290323 19.4 19 4 abnormal behavior 2.17012657822188e-22 7.19758648443591e-20 1.35859218730154 0.579136690647482 19.4 19 4 lethality throughout fetal growth and development, complete penetrance 9.30361080878586e-16 1.49307947657128e-13 1.35814805778625 0.578947368421053 19.4 19 4 decreased hair follicle number 0.000304214310183645 0.0040575501157202 1.35814805778624 0.578947368421053 19.4 19 4 decreased neuron apoptosis 0.000304214310183645 0.0040575501157202 1.35814805778624 0.578947368421053 19.4 19 4 small superior vagus ganglion 0.010207580277846 0.0640172576662153 1.35814805778624 0.578947368421053 19.4 19 4 abnormal long term depression 0.010207580277846 0.0640172576662153 1.35814805778624 0.578947368421053 19.4 19 4 delayed sexual maturation 0.010207580277846 0.0640172576662153 1.35814805778624 0.578947368421053 19.4 19 4 increased malignant tumor incidence 0.010207580277846 0.0640172576662153 1.35814805778624 0.578947368421053 19.4 19 4 abnormal neural crest cell migration 0.010207580277846 0.0640172576662153 1.35814805778624 0.578947368421053 19.4 19 4 increased susceptibility to ischemic brain injury 0.010207580277846 0.0640172576662153 1.35814805778624 0.578947368421053 19.4 19 4 abnormal digestive system development 0.010207580277846 0.0640172576662153 1.35814805778624 0.578947368421053 19.4 19 4 abnormal sternebra morphology 0.010207580277846 0.0640172576662153 1.35814805778624 0.578947368421053 19.4 19 4 Leydig cell hypoplasia 0.010207580277846 0.0640172576662153 1.35814805778624 0.578947368421053 19.4 19 4 lethality at weaning, complete penetrance 9.20448505842035e-05 0.00150632609097504 1.35540432433617 0.577777777777778 19.4 19 4 small liver 3.06261636475588e-07 1.06549065836787e-05 1.35339928835343 0.576923076923077 19.4 19 4 eyelids open at birth 2.81239494792382e-05 0.000557436847247849 1.35339928835343 0.576923076923077 19.4 19 4 abnormal lung development 9.58085054875755e-08 3.90694520328433e-06 1.3523377987155 0.576470588235294 19.4 19 4 abnormal neuron morphology 9.44271152412442e-09 4.87671643526236e-07 1.35066514837695 0.575757575757576 19.4 19 4 abnormal tooth development 0.00085558132985118 0.00941707326550801 1.35066514837695 0.575757575757576 19.4 19 4 abnormal cranium morphology 2.95645971601837e-11 2.67425219767116e-09 1.34801262451918 0.574626865671642 19.4 19 4 abnormal axon morphology 2.5265761259931e-09 1.43568597301624e-07 1.34671583507761 0.574074074074074 19.4 19 4 abnormal skeleton morphology 7.96707551337685e-10 5.01724059228479e-08 1.34633807467506 0.573913043478261 19.4 19 4 increased insulin sensitivity 7.95822006671941e-12 7.61387400614021e-10 1.34519686842401 0.573426573426573 19.4 19 4 preweaning lethality, complete penetrance 3.58429054824317e-55 8.91592273875489e-52 1.34413277070344 0.572972972972973 19.4 19 4 cleft palate 6.75503978580705e-11 5.60105382239835e-09 1.34306799607592 0.572519083969466 19.4 19 4 polydactyly 1.83750528427314e-08 8.62414036722536e-07 1.34050977132149 0.571428571428571 19.4 19 4 arrest of spermatogenesis 1.8680085173961e-07 6.98747546920722e-06 1.34050977132149 0.571428571428571 19.4 19 4 domed cranium 1.91993807594322e-06 5.42709768625995e-05 1.34050977132149 0.571428571428571 19.4 19 4 abnormal embryonic epiblast morphology 0.000716991757257553 0.00800640390997516 1.34050977132149 0.571428571428571 19.4 19 4 abnormal somite shape 0.00242800785854769 0.0212039325554327 1.34050977132149 0.571428571428571 19.4 19 4 hypoxia 0.00242800785854769 0.0212039325554327 1.34050977132149 0.571428571428571 19.4 19 4 abnormal renal tubule epithelium morphology 0.00242800785854769 0.0212039325554327 1.34050977132149 0.571428571428571 19.4 19 4 abnormal scapula morphology 0.00844185512809899 0.0546140822656599 1.34050977132149 0.571428571428571 19.4 19 4 increased incidence of induced tumors 0.00844185512809899 0.0546140822656599 1.34050977132149 0.571428571428571 19.4 19 4 abnormal erythrocyte physiology 0.00844185512809899 0.0546140822656599 1.34050977132149 0.571428571428571 19.4 19 4 abnormal embryonic/fetal subventricular zone morphology 0.00844185512809899 0.0546140822656599 1.34050977132149 0.571428571428571 19.4 19 4 translucent skin 0.0307503451393692 0.132338206806541 1.34050977132149 0.571428571428571 19.4 19 4 abnormal placing response 0.0307503451393692 0.132338206806541 1.34050977132149 0.571428571428571 19.4 19 4 abnormal fluid regulation 0.0307503451393692 0.132338206806541 1.34050977132149 0.571428571428571 19.4 19 4 amyloid beta deposits 0.0307503451393692 0.132338206806541 1.34050977132149 0.571428571428571 19.4 19 4 abnormal sagittal suture morphology 0.0307503451393692 0.132338206806541 1.34050977132149 0.571428571428571 19.4 19 4 abnormal squamosal bone morphology 0.0307503451393692 0.132338206806541 1.34050977132149 0.571428571428571 19.4 19 4 abnormal viscerocranium morphology 0.0307503451393692 0.132338206806541 1.34050977132149 0.571428571428571 19.4 19 4 increased stomach tumor incidence 0.0307503451393692 0.132338206806541 1.34050977132149 0.571428571428571 19.4 19 4 decreased compact bone area 0.0307503451393692 0.132338206806541 1.34050977132149 0.571428571428571 19.4 19 4 abnormal renal tubule epithelial cell primary cilium morphology 0.0307503451393692 0.132338206806541 1.34050977132149 0.571428571428571 19.4 19 4 abnormal definitive hematopoiesis 4.95733257059675e-08 2.16339732795779e-06 1.33690625043084 0.56989247311828 19.4 19 4 small kidney 1.33781935243944e-07 5.24067029794189e-06 1.33289323852989 0.568181818181818 19.4 19 4 muscular atrophy 0.000180828199421874 0.00275113239181597 1.33289323852989 0.568181818181818 19.4 19 4 increased neuron apoptosis 4.27559702079064e-07 1.40868179989625e-05 1.33223501964666 0.567901234567901 19.4 19 4 absent mesoderm 1.42499863086132e-05 0.000308233399501524 1.32933885656048 0.566666666666667 19.4 19 4 intracranial hemorrhage 1.42499863086132e-05 0.000308233399501524 1.32933885656048 0.566666666666667 19.4 19 4 disorganized myocardium 0.00202211280323584 0.0185267241180448 1.32933885656048 0.566666666666667 19.4 19 4 enhanced paired-pulse facilitation 0.00202211280323584 0.0185267241180448 1.32933885656048 0.566666666666667 19.4 19 4 abnormal optic cup morphology 0.00202211280323584 0.0185267241180448 1.32933885656048 0.566666666666667 19.4 19 4 enlarged kidney 4.63186883729762e-05 0.000834911140056365 1.32786345272412 0.566037735849057 19.4 19 4 increased circulating bilirubin level 4.63186883729762e-05 0.000834911140056365 1.32786345272412 0.566037735849057 19.4 19 4 hemorrhage 1.34948207769791e-17 3.0516696984305e-15 1.3276751032982 0.565957446808511 19.4 19 4 conjunctivitis 0.00697479567297904 0.0483955487769466 1.32593901293756 0.565217391304348 19.4 19 4 abnormal corneal stroma morphology 0.00697479567297904 0.0483955487769466 1.32593901293756 0.565217391304348 19.4 19 4 decreased effector memory CD8-positive, alpha-beta T cell number 0.00697479567297904 0.0483955487769466 1.32593901293756 0.565217391304348 19.4 19 4 hydroencephaly 2.51702404982043e-09 1.43568597301624e-07 1.32593901293756 0.565217391304348 19.4 19 4 abnormal vitelline vasculature morphology 2.51702404982043e-09 1.43568597301624e-07 1.32593901293756 0.565217391304348 19.4 19 4 abnormal nervous system physiology 2.51702404982043e-09 1.43568597301624e-07 1.32593901293756 0.565217391304348 19.4 19 4 decreased spleen weight 3.71648739753873e-06 9.44889519267485e-05 1.32593901293756 0.565217391304348 19.4 19 4 perimembraneous ventricular septal defect 3.71648739753873e-06 9.44889519267485e-05 1.32593901293756 0.565217391304348 19.4 19 4 increased tumor incidence 6.7208149527578e-10 4.28667363973975e-08 1.32429392731357 0.564516129032258 19.4 19 4 abnormal embryo turning 3.89118907484963e-05 0.000729209703346241 1.32223009262165 0.563636363636364 19.4 19 4 abnormal rostral-caudal axis patterning 3.89118907484963e-05 0.000729209703346241 1.32223009262165 0.563636363636364 19.4 19 4 embryonic growth arrest 6.87400683593066e-17 1.42492433369813e-14 1.32148506932675 0.563318777292576 19.4 19 4 absent mandible 0.0250246458009275 0.122537020531116 1.31956430614459 0.5625 19.4 19 4 white spotting 0.0250246458009275 0.122537020531116 1.31956430614459 0.5625 19.4 19 4 increased intestinal adenocarcinoma incidence 0.0250246458009275 0.122537020531116 1.31956430614459 0.5625 19.4 19 4 increased thymus weight 0.0250246458009275 0.122537020531116 1.31956430614459 0.5625 19.4 19 4 dystonia 0.0250246458009275 0.122537020531116 1.31956430614459 0.5625 19.4 19 4 decreased liver cholesterol level 0.0250246458009275 0.122537020531116 1.31956430614459 0.5625 19.4 19 4 decreased adipocyte glucose uptake 0.0250246458009275 0.122537020531116 1.31956430614459 0.5625 19.4 19 4 preweaning lethality, incomplete penetrance 8.12412747760699e-29 3.67432129100862e-26 1.31920582630049 0.562347188264059 19.4 19 4 perinatal lethality, incomplete penetrance 1.54748593069131e-16 2.74955089471045e-14 1.31826679945222 0.561946902654867 19.4 19 4 increased circulating alkaline phosphatase level 2.92083004447161e-12 3.02731863984297e-10 1.31775420421572 0.561728395061728 19.4 19 4 seminiferous tubule degeneration 2.63464933721753e-06 7.04697873798775e-05 1.31755583688105 0.561643835616438 19.4 19 4 reduced fertility 1.08418916676303e-10 8.2982170840709e-09 1.31639988334808 0.561151079136691 19.4 19 4 thick ventricular wall 0.00041905570852461 0.00529032805276797 1.31598825111439 0.560975609756098 19.4 19 4 embryonic lethality during organogenesis, incomplete penetrance 1.10557694174527e-16 2.037127883401e-14 1.31573948206881 0.560869565217391 19.4 19 4 increased hemoglobin content 2.74004392668516e-05 0.000545268741410346 1.31210914057315 0.559322033898305 19.4 19 4 lung hemorrhage 0.00139882849420719 0.0139742404792786 1.31093970283646 0.558823529411765 19.4 19 4 abnormal endoderm development 0.00139882849420719 0.0139742404792786 1.31093970283646 0.558823529411765 19.4 19 4 abnormal nervous system development 0.00139882849420719 0.0139742404792786 1.31093970283646 0.558823529411765 19.4 19 4 abnormal direction of heart looping 0.00139882849420719 0.0139742404792786 1.31093970283646 0.558823529411765 19.4 19 4 increased oxygen consumption 4.9015086748594e-07 1.60148890505916e-05 1.3093351254768 0.558139534883721 19.4 19 4 delayed endochondral bone ossification 0.000349793050151002 0.00455555084947968 1.3093351254768 0.558139534883721 19.4 19 4 microphthalmia 3.29169260319114e-11 2.91264672591315e-09 1.30327338878478 0.555555555555556 19.4 19 4 increased mean corpuscular hemoglobin 9.16321501275524e-08 3.76752022218656e-06 1.30327338878478 0.555555555555556 19.4 19 4 abnormal cartilage development 0.000291807385468961 0.00391305051942878 1.30327338878478 0.555555555555556 19.4 19 4 heart right ventricle hypertrophy 0.00116239176210345 0.012277917232409 1.30327338878478 0.555555555555556 19.4 19 4 abnormal trigeminal ganglion morphology 0.00475466736105602 0.0353051792854533 1.30327338878478 0.555555555555556 19.4 19 4 abnormal brain commissure morphology 0.00475466736105602 0.0353051792854533 1.30327338878478 0.555555555555556 19.4 19 4 decreased bone ossification 0.00475466736105602 0.0353051792854533 1.30327338878478 0.555555555555556 19.4 19 4 abnormal heart shape 0.0203866257366979 0.105759606923954 1.30327338878478 0.555555555555556 19.4 19 4 underdeveloped hair follicles 0.0203866257366979 0.105759606923954 1.30327338878478 0.555555555555556 19.4 19 4 abnormal thymus cortex morphology 0.0203866257366979 0.105759606923954 1.30327338878478 0.555555555555556 19.4 19 4 absent inner cell mass 0.0203866257366979 0.105759606923954 1.30327338878478 0.555555555555556 19.4 19 4 abnormal anterior eye segment morphology 0.0203866257366979 0.105759606923954 1.30327338878478 0.555555555555556 19.4 19 4 decreased lactate dehydrogenase level 0.0203866257366979 0.105759606923954 1.30327338878478 0.555555555555556 19.4 19 4 abnormal pregnancy 0.0203866257366979 0.105759606923954 1.30327338878478 0.555555555555556 19.4 19 4 decreased tumor latency 0.0203866257366979 0.105759606923954 1.30327338878478 0.555555555555556 19.4 19 4 increased effector memory CD8-positive, alpha-beta T cell number 0.0203866257366979 0.105759606923954 1.30327338878478 0.555555555555556 19.4 19 4 distorted hair follicle pattern 0.0974060999527366 0.279466751594501 1.30327338878478 0.555555555555556 19.4 19 4 abnormal urinary bladder urothelium morphology 0.0974060999527366 0.279466751594501 1.30327338878478 0.555555555555556 19.4 19 4 abnormal sympathetic neuron morphology 0.0974060999527366 0.279466751594501 1.30327338878478 0.555555555555556 19.4 19 4 abnormal cholinergic neuron morphology 0.0974060999527366 0.279466751594501 1.30327338878478 0.555555555555556 19.4 19 4 small geniculate ganglion 0.0974060999527366 0.279466751594501 1.30327338878478 0.555555555555556 19.4 19 4 multifocal hepatic necrosis 0.0974060999527366 0.279466751594501 1.30327338878478 0.555555555555556 19.4 19 4 abnormal germ cell morphology 0.0974060999527366 0.279466751594501 1.30327338878478 0.555555555555556 19.4 19 4 abnormal vomeronasal organ morphology 0.0974060999527366 0.279466751594501 1.30327338878478 0.555555555555556 19.4 19 4 abnormal laryngeal cartilage morphology 0.0974060999527366 0.279466751594501 1.30327338878478 0.555555555555556 19.4 19 4 polycythemia 0.0974060999527366 0.279466751594501 1.30327338878478 0.555555555555556 19.4 19 4 genetic imprinting 0.0974060999527366 0.279466751594501 1.30327338878478 0.555555555555556 19.4 19 4 abnormal abdominal wall morphology 0.0974060999527366 0.279466751594501 1.30327338878478 0.555555555555556 19.4 19 4 abnormal thymus physiology 0.0974060999527366 0.279466751594501 1.30327338878478 0.555555555555556 19.4 19 4 liver hyperplasia 0.0974060999527366 0.279466751594501 1.30327338878478 0.555555555555556 19.4 19 4 abnormal posterior eye segment morphology 0.0974060999527366 0.279466751594501 1.30327338878478 0.555555555555556 19.4 19 4 decreased susceptibility to atherosclerosis 0.0974060999527366 0.279466751594501 1.30327338878478 0.555555555555556 19.4 19 4 abnormal optic chiasm morphology 0.0974060999527366 0.279466751594501 1.30327338878478 0.555555555555556 19.4 19 4 abnormal retinal development 0.0974060999527366 0.279466751594501 1.30327338878478 0.555555555555556 19.4 19 4 abnormal hippocampus granule cell morphology 0.0974060999527366 0.279466751594501 1.30327338878478 0.555555555555556 19.4 19 4 abnormal telomere morphology 0.0974060999527366 0.279466751594501 1.30327338878478 0.555555555555556 19.4 19 4 abnormal ventricle myocardium morphology 0.0974060999527366 0.279466751594501 1.30327338878478 0.555555555555556 19.4 19 4 fusion of atlas and occipital bones 0.0974060999527366 0.279466751594501 1.30327338878478 0.555555555555556 19.4 19 4 abnormal pulmonary alveolar parenchyma morphology 0.0974060999527366 0.279466751594501 1.30327338878478 0.555555555555556 19.4 19 4 abnormal lung lobe morphology 0.0974060999527366 0.279466751594501 1.30327338878478 0.555555555555556 19.4 19 4 trigeminal neuroma 0.0974060999527366 0.279466751594501 1.30327338878478 0.555555555555556 19.4 19 4 abnormal ductus venosus valve topology 0.0974060999527366 0.279466751594501 1.30327338878478 0.555555555555556 19.4 19 4 abnormal coronary sinus connection 0.0974060999527366 0.279466751594501 1.30327338878478 0.555555555555556 19.4 19 4 symmetric azygos veins 0.0974060999527366 0.279466751594501 1.30327338878478 0.555555555555556 19.4 19 4 decreased bone mineral density of femur 0.0974060999527366 0.279466751594501 1.30327338878478 0.555555555555556 19.4 19 4 decreased platelet dense granule number 0.0974060999527366 0.279466751594501 1.30327338878478 0.555555555555556 19.4 19 4 pulmonary hypoplasia 0.000243316324970558 0.00344871429267387 1.29772754457719 0.553191489361702 19.4 19 4 persistence of hyaloid vascular system 0.000965530679202967 0.0105109740241461 1.2964140551596 0.552631578947368 19.4 19 4 abnormal parietal bone morphology 0.00392476450443069 0.0308951003315549 1.29428529644833 0.551724137931034 19.4 19 4 aphagia 0.00392476450443069 0.0308951003315549 1.29428529644833 0.551724137931034 19.4 19 4 double outlet right ventricle 4.56762199650349e-08 2.02468516501666e-06 1.29352928868172 0.551401869158878 19.4 19 4 increased rib number 2.95385195995469e-06 7.81670930892264e-05 1.29324820887105 0.551282051282051 19.4 19 4 abnormal long bone hypertrophic chondrocyte zone 0.000202801993059873 0.00301176094171005 1.29263442234572 0.551020408163265 19.4 19 4 increased startle reflex 6.51480869544365e-07 2.02569832873951e-05 1.29155857180694 0.550561797752809 19.4 19 4 abnormal circulating enzyme level 0.0166273724343667 0.0896220778558766 1.29024065489693 0.55 19.4 19 4 abnormal trachea morphology 0.0166273724343667 0.0896220778558766 1.29024065489693 0.55 19.4 19 4 abnormal hyoid bone morphology 0.0166273724343667 0.0896220778558766 1.29024065489693 0.55 19.4 19 4 abnormal postnatal subventricular zone morphology 0.0166273724343667 0.0896220778558766 1.29024065489693 0.55 19.4 19 4 abnormal incus morphology 0.0166273724343667 0.0896220778558766 1.29024065489693 0.55 19.4 19 4 decreased muscle cell glucose uptake 0.0166273724343667 0.0896220778558766 1.29024065489693 0.55 19.4 19 4 abnormal cued conditioning behavior 0.000168977521907779 0.00259463941818272 1.28794076068143 0.549019607843137 19.4 19 4 abnormal gastrulation 0.000168977521907779 0.00259463941818272 1.28794076068143 0.549019607843137 19.4 19 4 abnormal excitatory postsynaptic potential 2.07196147411988e-06 5.79101591783505e-05 1.28737981087277 0.548780487804878 19.4 19 4 pericardial effusion 3.63009024706624e-05 0.00069460380689056 1.28645695796175 0.548387096774194 19.4 19 4 abnormal nose morphology 0.00323980892968017 0.0273651093805753 1.28645695796175 0.548387096774194 19.4 19 4 inner cell mass degeneration 0.00323980892968017 0.0273651093805753 1.28645695796175 0.548387096774194 19.4 19 4 small cranium 0.00323980892968017 0.0273651093805753 1.28645695796175 0.548387096774194 19.4 19 4 decreased bone mineral content 5.6529783821793e-14 7.0308918628355e-12 1.28572932393575 0.548076923076923 19.4 19 4 disheveled coat 0.000665647176198819 0.0076128613829635 1.28465519751643 0.547619047619048 19.4 19 4 abnormal muscle morphology 0.000665647176198819 0.0076128613829635 1.28465519751643 0.547619047619048 19.4 19 4 extramedullary hematopoiesis 8.51926137530445e-08 3.53194377851164e-06 1.28360133763331 0.547169811320755 19.4 19 4 prenatal lethality, incomplete penetrance 1.89787860106229e-19 4.96944528436047e-17 1.28098055450294 0.546052631578947 19.4 19 4 abnormal amino acid level 0.000552550871025959 0.00663173381392318 1.27957750898869 0.545454545454545 19.4 19 4 embryonic lethality, incomplete penetrance 0.000552550871025959 0.00663173381392318 1.27957750898869 0.545454545454545 19.4 19 4 abnormal long bone epiphysis morphology 0.0135769797626017 0.0761504783753592 1.27957750898869 0.545454545454545 19.4 19 4 increased myocardial infarction size 0.0135769797626017 0.0761504783753592 1.27957750898869 0.545454545454545 19.4 19 4 increased coping response 0.0135769797626017 0.0761504783753592 1.27957750898869 0.545454545454545 19.4 19 4 abnormal tracheal cartilage morphology 0.0135769797626017 0.0761504783753592 1.27957750898869 0.545454545454545 19.4 19 4 abnormal lysosome physiology 0.0135769797626017 0.0761504783753592 1.27957750898869 0.545454545454545 19.4 19 4 cleft upper lip 0.0135769797626017 0.0761504783753592 1.27957750898869 0.545454545454545 19.4 19 4 abnormal sperm midpiece morphology 0.0135769797626017 0.0761504783753592 1.27957750898869 0.545454545454545 19.4 19 4 abnormal cerebral cortex pyramidal cell morphology 0.0135769797626017 0.0761504783753592 1.27957750898869 0.545454545454545 19.4 19 4 increased mammary gland tumor incidence 0.0135769797626017 0.0761504783753592 1.27957750898869 0.545454545454545 19.4 19 4 increased adenoma incidence 0.0135769797626017 0.0761504783753592 1.27957750898869 0.545454545454545 19.4 19 4 increased bone volume 0.0135769797626017 0.0761504783753592 1.27957750898869 0.545454545454545 19.4 19 4 abnormal thrombopoiesis 0.0769236038572615 0.260869072385737 1.27957750898869 0.545454545454545 19.4 19 4 abnormal awl hair morphology 0.0769236038572615 0.260869072385737 1.27957750898869 0.545454545454545 19.4 19 4 abnormal sebaceous gland morphology 0.0769236038572615 0.260869072385737 1.27957750898869 0.545454545454545 19.4 19 4 abnormal glossopharyngeal ganglion morphology 0.0769236038572615 0.260869072385737 1.27957750898869 0.545454545454545 19.4 19 4 failure of somite differentiation 0.0769236038572615 0.260869072385737 1.27957750898869 0.545454545454545 19.4 19 4 abnormal primary sex determination 0.0769236038572615 0.260869072385737 1.27957750898869 0.545454545454545 19.4 19 4 retinal detachment 0.0769236038572615 0.260869072385737 1.27957750898869 0.545454545454545 19.4 19 4 abnormal Bruch membrane morphology 0.0769236038572615 0.260869072385737 1.27957750898869 0.545454545454545 19.4 19 4 increased glycogen level 0.0769236038572615 0.260869072385737 1.27957750898869 0.545454545454545 19.4 19 4 abnormal palatal shelf elevation 0.0769236038572615 0.260869072385737 1.27957750898869 0.545454545454545 19.4 19 4 aberrant origin of the right subclavian artery 0.0769236038572615 0.260869072385737 1.27957750898869 0.545454545454545 19.4 19 4 thin hypoglossal nerve 0.0769236038572615 0.260869072385737 1.27957750898869 0.545454545454545 19.4 19 4 reduced sympathetic cervical ganglion size 0.0769236038572615 0.260869072385737 1.27957750898869 0.545454545454545 19.4 19 4 abnormal locomotor coordination 0.00267468909066429 0.0231418751757476 1.27957750898869 0.545454545454545 19.4 19 4 increased osteoblast cell number 0.00267468909066429 0.0231418751757476 1.27957750898869 0.545454545454545 19.4 19 4 myeloid hyperplasia 0.00267468909066429 0.0231418751757476 1.27957750898869 0.545454545454545 19.4 19 4 abnormal blood vessel morphology 5.62803294119083e-10 3.68413998452952e-08 1.27810673024273 0.544827586206897 19.4 19 4 abnormal coat/hair pigmentation 5.01186438262849e-08 2.1681761133545e-06 1.27767337579079 0.544642857142857 19.4 19 4 abnormal heart development 1.06135105015557e-10 8.25034605394366e-09 1.27687797837901 0.544303797468354 19.4 19 4 hunched posture 4.61219710014095e-06 0.00011369331268335 1.27687797837901 0.544303797468354 19.4 19 4 atrial septal defect 0.000458625032077419 0.00570414883646289 1.27494135859381 0.543478260869565 19.4 19 4 abnormal startle reflex 0.0110985338312501 0.0645037451056882 1.27069155406516 0.541666666666667 19.4 19 4 blindness 0.0110985338312501 0.0645037451056882 1.27069155406516 0.541666666666667 19.4 19 4 increased hemangiosarcoma incidence 0.0110985338312501 0.0645037451056882 1.27069155406516 0.541666666666667 19.4 19 4 abnormal osteoblast morphology 0.0110985338312501 0.0645037451056882 1.27069155406516 0.541666666666667 19.4 19 4 abnormal retinal ganglion layer morphology 0.0110985338312501 0.0645037451056882 1.27069155406516 0.541666666666667 19.4 19 4 abnormal neuromuscular synapse morphology 1.46827631443895e-05 0.000316219682438692 1.27069155406516 0.541666666666667 19.4 19 4 abnormal cardiovascular system physiology 4.61757870483836e-09 2.55249489517454e-07 1.26995662546246 0.541353383458647 19.4 19 4 kidney cysts 1.22447718534522e-05 0.000274404234103264 1.26804978368249 0.540540540540541 19.4 19 4 abnormal vocalization 0.00182395104692154 0.0168978704998783 1.26804978368249 0.540540540540541 19.4 19 4 impaired skeletal muscle contractility 0.00182395104692154 0.0168978704998783 1.26804978368249 0.540540540540541 19.4 19 4 abnormal humerus morphology 0.00182395104692154 0.0168978704998783 1.26804978368249 0.540540540540541 19.4 19 4 abnormal liver physiology 4.15023296276547e-07 1.38573214696364e-05 1.26678173389881 0.54 19.4 19 4 abnormal interventricular septum morphology 0.000315911928880308 0.00417995171856259 1.26678173389881 0.54 19.4 19 4 increased B cell derived lymphoma incidence 0.000315911928880308 0.00417995171856259 1.26678173389881 0.54 19.4 19 4 increased circulating chloride level 0.000315911928880308 0.00417995171856259 1.26678173389881 0.54 19.4 19 4 increased spleen weight 7.7228901064506e-08 3.22868725038586e-06 1.26636653175725 0.539823008849557 19.4 19 4 increased grip strength 1.56432288431254e-06 4.52471299386912e-05 1.26317266912986 0.538461538461538 19.4 19 4 distended pericardium 0.000262188236548515 0.00358347933194742 1.26317266912986 0.538461538461538 19.4 19 4 abnormal snout morphology 0.000262188236548515 0.00358347933194742 1.26317266912986 0.538461538461538 19.4 19 4 abnormal Schwann cell morphology 0.00908206254111225 0.0583009821187528 1.26317266912986 0.538461538461538 19.4 19 4 thick skin 0.00908206254111225 0.0583009821187528 1.26317266912986 0.538461538461538 19.4 19 4 increased leukemia incidence 0.00908206254111225 0.0583009821187528 1.26317266912986 0.538461538461538 19.4 19 4 abnormal nerve conduction 0.00908206254111225 0.0583009821187528 1.26317266912986 0.538461538461538 19.4 19 4 absent common myeloid progenitor cells 0.061186404444892 0.222488615971456 1.26317266912986 0.538461538461538 19.4 19 4 absent trabeculae carneae 0.061186404444892 0.222488615971456 1.26317266912986 0.538461538461538 19.4 19 4 increased foot pad pigmentation 0.061186404444892 0.222488615971456 1.26317266912986 0.538461538461538 19.4 19 4 abnormal grip strength 0.061186404444892 0.222488615971456 1.26317266912986 0.538461538461538 19.4 19 4 abnormal digestion 0.061186404444892 0.222488615971456 1.26317266912986 0.538461538461538 19.4 19 4 increased pituitary adenoma incidence 0.061186404444892 0.222488615971456 1.26317266912986 0.538461538461538 19.4 19 4 abnormal tail bud morphology 0.061186404444892 0.222488615971456 1.26317266912986 0.538461538461538 19.4 19 4 increased synaptic depression 0.061186404444892 0.222488615971456 1.26317266912986 0.538461538461538 19.4 19 4 anal atresia 0.061186404444892 0.222488615971456 1.26317266912986 0.538461538461538 19.4 19 4 small otic vesicle 0.061186404444892 0.222488615971456 1.26317266912986 0.538461538461538 19.4 19 4 abnormal exocrine pancreas morphology 0.061186404444892 0.222488615971456 1.26317266912986 0.538461538461538 19.4 19 4 small pituitary gland 0.061186404444892 0.222488615971456 1.26317266912986 0.538461538461538 19.4 19 4 increased circulating thyroxine level 0.061186404444892 0.222488615971456 1.26317266912986 0.538461538461538 19.4 19 4 orthokeratosis 0.061186404444892 0.222488615971456 1.26317266912986 0.538461538461538 19.4 19 4 empty decidua capsularis 0.061186404444892 0.222488615971456 1.26317266912986 0.538461538461538 19.4 19 4 abnormal aorta tunica media morphology 0.061186404444892 0.222488615971456 1.26317266912986 0.538461538461538 19.4 19 4 insulin resistance 8.45161093387717e-09 4.52115746193967e-07 1.26180559914163 0.537878787878788 19.4 19 4 hypoglycemia 1.30572386161968e-06 3.84377290624729e-05 1.26123231172721 0.537634408602151 19.4 19 4 respiratory distress 4.71982710185633e-11 4.04847238478194e-09 1.26108650452354 0.53757225433526 19.4 19 4 rib fusion 3.89889007216282e-05 0.000729209703346241 1.26047933721274 0.537313432835821 19.4 19 4 palatal shelves fail to meet at midline 0.00124491897819003 0.0128495267977083 1.25877137063115 0.536585365853659 19.4 19 4 lethality at weaning, incomplete penetrance 0.00124491897819003 0.0128495267977083 1.25877137063115 0.536585365853659 19.4 19 4 abnormal motor coordination/ balance 7.58856202627043e-07 2.34491280004319e-05 1.25588162919261 0.535353535353535 19.4 19 4 seizures 1.17801313893715e-07 4.68849229296985e-06 1.2552580534085 0.535087719298246 19.4 19 4 abnormal left-right axis patterning 0.00102887942115381 0.0110793833771433 1.2547794952486 0.534883720930233 19.4 19 4 azoospermia 4.54424093056272e-10 3.01434648393994e-08 1.25409326090611 0.534591194968553 19.4 19 4 postnatal growth retardation 1.59507447544561e-34 9.91936939417742e-32 1.25344234744889 0.534313725490196 19.4 19 4 hyperglycemia 3.42506518466039e-06 8.82885973766086e-05 1.2529196442181 0.534090909090909 19.4 19 4 abnormal bone structure 7.92616889618714e-12 7.61387400614021e-10 1.25195277865647 0.533678756476684 19.4 19 4 abnormal limb morphology 1.86916142898795e-05 0.000384259426000622 1.25114245323339 0.533333333333333 19.4 19 4 muscular ventricular septal defect 0.000124433442462449 0.00197781589856448 1.25114245323339 0.533333333333333 19.4 19 4 irregular heartbeat 0.000850543425948245 0.00938238036384151 1.25114245323339 0.533333333333333 19.4 19 4 abnormal hair cycle 0.00609922359151046 0.04353463036982 1.25114245323339 0.533333333333333 19.4 19 4 abnormal fontanelle morphology 0.0489383812870282 0.189678769718846 1.25114245323339 0.533333333333333 19.4 19 4 abnormal apical ectodermal ridge morphology 0.0489383812870282 0.189678769718846 1.25114245323339 0.533333333333333 19.4 19 4 placental labyrinth hypoplasia 0.0489383812870282 0.189678769718846 1.25114245323339 0.533333333333333 19.4 19 4 arthritis 0.0489383812870282 0.189678769718846 1.25114245323339 0.533333333333333 19.4 19 4 decreased aggression towards males 0.0489383812870282 0.189678769718846 1.25114245323339 0.533333333333333 19.4 19 4 immune system phenotype 0.0489383812870282 0.189678769718846 1.25114245323339 0.533333333333333 19.4 19 4 abnormal secondary palate development 0.0489383812870282 0.189678769718846 1.25114245323339 0.533333333333333 19.4 19 4 ostium primum atrial septal defect 0.0489383812870282 0.189678769718846 1.25114245323339 0.533333333333333 19.4 19 4 increased or absent threshold for auditory brainstem response 7.32227695016851e-17 1.45713311308353e-14 1.25006015007315 0.532871972318339 19.4 19 4 decreased leukocyte cell number 8.96023898279219e-09 4.73963826235008e-07 1.25000089990015 0.532846715328467 19.4 19 4 neuron degeneration 0.000703294017426122 0.00793398579749423 1.24781494670883 0.531914893617021 19.4 19 4 abnormal nervous system morphology 1.29404376532846e-05 0.000284861404093323 1.24718314167252 0.531645569620253 19.4 19 4 retinal degeneration 1.65153881137185e-06 4.7220721761925e-05 1.24625517802545 0.53125 19.4 19 4 decreased caudal vertebrae number 8.57520014619542e-05 0.00142205402424407 1.24625517802545 0.53125 19.4 19 4 increased sacral vertebrae number 8.57520014619542e-05 0.00142205402424407 1.24625517802545 0.53125 19.4 19 4 polydipsia 0.00500481742361295 0.036401998073793 1.24625517802545 0.53125 19.4 19 4 failure of primitive streak formation 0.00500481742361295 0.036401998073793 1.24625517802545 0.53125 19.4 19 4 increased circulating follicle stimulating hormone level 0.00500481742361295 0.036401998073793 1.24625517802545 0.53125 19.4 19 4 neonatal lethality 0.00500481742361295 0.036401998073793 1.24625517802545 0.53125 19.4 19 4 pancreatic islet hyperplasia 0.00500481742361295 0.036401998073793 1.24625517802545 0.53125 19.4 19 4 abnormal auditory brainstem response waveform shape 0.00500481742361295 0.036401998073793 1.24625517802545 0.53125 19.4 19 4 abnormal embryonic tissue morphology 3.63902839400898e-09 2.03417598429154e-07 1.24475907336995 0.530612244897959 19.4 19 4 absent kidney 0.000581680572701646 0.00689014487902545 1.24475907336995 0.530612244897959 19.4 19 4 perinatal lethality, complete penetrance 1.32046305233752e-12 1.42810949682156e-10 1.24453430647335 0.530516431924883 19.4 19 4 abnormal motor capabilities/coordination/movement 2.31866053000745e-08 1.06808667933214e-06 1.24403368929456 0.53030303030303 19.4 19 4 decreased double-positive T cell number 1.14658267149037e-06 3.3953861849194e-05 1.24332281290068 0.53 19.4 19 4 distended abdomen 0.000481213136724401 0.00594053438015855 1.24194287637138 0.529411764705882 19.4 19 4 abnormal gluconeogenesis 0.000481213136724401 0.00594053438015855 1.24194287637138 0.529411764705882 19.4 19 4 abnormal brown adipose tissue morphology 0.00411003226167855 0.0314567972161851 1.24194287637138 0.529411764705882 19.4 19 4 abnormal adipose tissue morphology 0.0393144921032565 0.160582592950493 1.24194287637138 0.529411764705882 19.4 19 4 hyperlipidemia 0.0393144921032565 0.160582592950493 1.24194287637138 0.529411764705882 19.4 19 4 decreased vasoconstriction 0.0393144921032565 0.160582592950493 1.24194287637138 0.529411764705882 19.4 19 4 abnormal involuntary movement 0.0393144921032565 0.160582592950493 1.24194287637138 0.529411764705882 19.4 19 4 abnormal tarsal bone morphology 0.0393144921032565 0.160582592950493 1.24194287637138 0.529411764705882 19.4 19 4 coloboma 0.0393144921032565 0.160582592950493 1.24194287637138 0.529411764705882 19.4 19 4 enhanced behavioral response to cocaine 0.0393144921032565 0.160582592950493 1.24194287637138 0.529411764705882 19.4 19 4 increased trabecular bone mass 0.0393144921032565 0.160582592950493 1.24194287637138 0.529411764705882 19.4 19 4 abnormal ductus venosus valve morphology 0.0393144921032565 0.160582592950493 1.24194287637138 0.529411764705882 19.4 19 4 decreased body fat mass 0.0393144921032565 0.160582592950493 1.24194287637138 0.529411764705882 19.4 19 4 abnormal cell cytoskeleton morphology 0.0393144921032565 0.160582592950493 1.24194287637138 0.529411764705882 19.4 19 4 abnormal bone mineralization 1.03191739147365e-07 4.14015243756566e-06 1.24080243295873 0.528925619834711 19.4 19 4 decreased erythrocyte cell number 1.47574738587902e-09 9.06400400586189e-08 1.24018499544233 0.528662420382166 19.4 19 4 abnormal mesoderm development 0.000398192663934065 0.00505359312008157 1.23933922254251 0.528301886792453 19.4 19 4 abnormal placenta development 0.000398192663934065 0.00505359312008157 1.23933922254251 0.528301886792453 19.4 19 4 atrioventricular septal defect 0.000398192663934065 0.00505359312008157 1.23933922254251 0.528301886792453 19.4 19 4 decreased rib number 5.16087520812795e-06 0.000124035527345104 1.23884189540666 0.528089887640449 19.4 19 4 short snout 5.52485894127066e-07 1.73963121726718e-05 1.23810971934554 0.527777777777778 19.4 19 4 reduced long term depression 0.00337770016565237 0.028156341285236 1.23810971934554 0.527777777777778 19.4 19 4 abnormal limb bone morphology 0.00337770016565237 0.028156341285236 1.23810971934554 0.527777777777778 19.4 19 4 abnormal pharyngeal arch morphology 0.00337770016565237 0.028156341285236 1.23810971934554 0.527777777777778 19.4 19 4 abnormal trophoblast giant cell morphology 0.00337770016565237 0.028156341285236 1.23810971934554 0.527777777777778 19.4 19 4 narrow eye opening 0.00337770016565237 0.028156341285236 1.23810971934554 0.527777777777778 19.4 19 4 abnormal retinal blood vessel morphology 0.00337770016565237 0.028156341285236 1.23810971934554 0.527777777777778 19.4 19 4 abnormal contextual conditioning behavior 0.000329571127219268 0.00432616453275952 1.23692492535574 0.527272727272727 19.4 19 4 decreased circulating total protein level 0.000329571127219268 0.00432616453275952 1.23692492535574 0.527272727272727 19.4 19 4 reduced long term potentiation 3.8347760469914e-07 1.306713070807e-05 1.235782445437 0.526785714285714 19.4 19 4 impaired branching involved in ureteric bud morphogenesis 0.00277775145549769 0.0238675535252177 1.23468005253295 0.526315789473684 19.4 19 4 abnormal triglyceride level 0.0316966762465332 0.135240964259436 1.23468005253295 0.526315789473684 19.4 19 4 shiny skin 0.0316966762465332 0.135240964259436 1.23468005253295 0.526315789473684 19.4 19 4 short vibrissae 0.0316966762465332 0.135240964259436 1.23468005253295 0.526315789473684 19.4 19 4 abnormal neurotransmitter level 0.0316966762465332 0.135240964259436 1.23468005253295 0.526315789473684 19.4 19 4 decreased germ cell number 0.0316966762465332 0.135240964259436 1.23468005253295 0.526315789473684 19.4 19 4 abnormal metatarsal bone morphology 0.0316966762465332 0.135240964259436 1.23468005253295 0.526315789473684 19.4 19 4 increased liver adenoma incidence 0.0316966762465332 0.135240964259436 1.23468005253295 0.526315789473684 19.4 19 4 abnormal cochlear inner hair cell morphology 0.0316966762465332 0.135240964259436 1.23468005253295 0.526315789473684 19.4 19 4 shortened RR interval 0.0316966762465332 0.135240964259436 1.23468005253295 0.526315789473684 19.4 19 4 incomplete embryo turning 0.000272836352423552 0.00368848057963906 1.23468005253295 0.526315789473684 19.4 19 4 abnormal circulating amino acid level 0.000272836352423552 0.00368848057963906 1.23468005253295 0.526315789473684 19.4 19 4 small testis 2.77641830486506e-15 4.06255325491285e-13 1.23244331330735 0.52536231884058 19.4 19 4 decreased body size 1.62850462135323e-41 1.62036209824647e-38 1.23174033812216 0.525062656641604 19.4 19 4 decreased body weight 2.91202432857643e-64 1.44873210346677e-60 1.2316880976399 0.525040387722132 19.4 19 4 decreased hemoglobin content 1.67557486097785e-08 8.0153701282354e-07 1.23117741408605 0.524822695035461 19.4 19 4 postnatal lethality, incomplete penetrance 9.30702474312276e-30 4.63024480970357e-27 1.23076733405661 0.524647887323944 19.4 19 4 abnormal gait 8.65786644534478e-17 1.65664944483039e-14 1.22988517854253 0.524271844660194 19.4 19 4 abnormal cartilage morphology 0.00188211796038038 0.0173720535304126 1.22880062371136 0.523809523809524 19.4 19 4 small ears 0.0256314414712611 0.12316504975042 1.22880062371136 0.523809523809524 19.4 19 4 trunk curl 0.0256314414712611 0.12316504975042 1.22880062371136 0.523809523809524 19.4 19 4 increased keratinocyte proliferation 0.0256314414712611 0.12316504975042 1.22880062371136 0.523809523809524 19.4 19 4 abnormal tumor vascularization 0.0256314414712611 0.12316504975042 1.22880062371136 0.523809523809524 19.4 19 4 teratozoospermia 9.24423371275371e-06 0.000212318228089996 1.2262617794475 0.522727272727273 19.4 19 4 limb grasping 2.49126885716499e-10 1.79624095136171e-08 1.22450411803405 0.521978021978022 19.4 19 4 abnormal sternum morphology 8.82039564493355e-05 0.0014482332783348 1.22394370425005 0.521739130434783 19.4 19 4 abnormal cranial nerve morphology 0.0207793624058264 0.107446918161485 1.22394370425005 0.521739130434783 19.4 19 4 hypotension 0.0207793624058264 0.107446918161485 1.22394370425005 0.521739130434783 19.4 19 4 abnormal nasal cavity morphology 0.0207793624058264 0.107446918161485 1.22394370425005 0.521739130434783 19.4 19 4 abnormal spatial learning 2.26360612543368e-09 1.35680005711235e-07 1.22331796615995 0.521472392638037 19.4 19 4 decreased startle reflex 3.94451423514138e-07 1.32594312971813e-05 1.22307194947495 0.521367521367521 19.4 19 4 anemia 1.10952214296275e-11 1.04148540778107e-09 1.22297692407292 0.52132701421801 19.4 19 4 abnormal ovary morphology 7.31198144941598e-05 0.00122895634158258 1.22250715060657 0.52112676056338 19.4 19 4 thymus atrophy 0.00105400168961302 0.0113253961248916 1.22181880198573 0.520833333333333 19.4 19 4 impaired coordination 4.87583478199518e-18 1.15510847811553e-15 1.2204062947002 0.520231213872832 19.4 19 4 decreased heart rate 3.04751351438171e-06 7.97967354423632e-05 1.21986389190255 0.52 19.4 19 4 decreased circulating alkaline phosphatase level 0.000869596603508093 0.0095291698291911 1.21986389190255 0.52 19.4 19 4 decreased respiratory quotient 0.000869596603508093 0.0095291698291911 1.21986389190255 0.52 19.4 19 4 kinked tail 2.53353249228128e-06 6.85017616798879e-05 1.21894393421635 0.519607843137255 19.4 19 4 impaired balance 2.53353249228128e-06 6.85017616798879e-05 1.21894393421635 0.519607843137255 19.4 19 4 abnormal brain wave pattern 0.000717760028914356 0.00800640390997516 1.21805935951808 0.519230769230769 19.4 19 4 abnormal somite development 3.45880812188532e-05 0.000664384957775269 1.21748830496604 0.518987341772152 19.4 19 4 decreased B cell proliferation 3.45880812188532e-05 0.000664384957775269 1.21748830496604 0.518987341772152 19.4 19 4 abnormal myocardium layer morphology 3.45880812188532e-05 0.000664384957775269 1.21748830496604 0.518987341772152 19.4 19 4 impaired limb coordination 0.000592672233838517 0.00693775144316853 1.21638849619913 0.518518518518518 19.4 19 4 abnormal heart valve morphology 0.0137423342734805 0.0768181045062536 1.21638849619913 0.518518518518518 19.4 19 4 rectal prolapse 0.0137423342734805 0.0768181045062536 1.21638849619913 0.518518518518518 19.4 19 4 decreased total body fat amount 3.74519439530522e-17 8.10101831158413e-15 1.21508782415443 0.517964071856287 19.4 19 4 enhanced long term potentiation 0.0004895686786746 0.00599902506503974 1.2148369802601 0.517857142857143 19.4 19 4 increased circulating triglyceride level 3.02897275083386e-08 1.38248985645857e-06 1.21339246542031 0.517241379310345 19.4 19 4 thrombocytosis 0.000404545198422707 0.00512115104873528 1.21339246542031 0.517241379310345 19.4 19 4 lordosis 0.011204820881018 0.06496967818539 1.21339246542031 0.517241379310345 19.4 19 4 abnormal outer ear morphology 0.011204820881018 0.06496967818539 1.21339246542031 0.517241379310345 19.4 19 4 epidermal hyperplasia 0.000334399969088058 0.00436650878271152 1.21204425156985 0.516666666666667 19.4 19 4 increased erythrocyte cell number 0.000334399969088058 0.00436650878271152 1.21204425156985 0.516666666666667 19.4 19 4 decreased thymus weight 0.00914926589746279 0.0586566982472647 1.21078301925812 0.516129032258065 19.4 19 4 abnormal heart morphology 4.61800366146923e-12 4.68868739098151e-10 1.20848986960043 0.515151515151515 19.4 19 4 decreased circulating serum albumin level 5.37341018539776e-06 0.000127907730489731 1.20848986960043 0.515151515151515 19.4 19 4 abnormal QRS complex 0.0074805787773709 0.0514031483666025 1.20848986960043 0.515151515151515 19.4 19 4 abnormal pulmonary alveolus morphology 4.46322398787777e-06 0.000111580599696944 1.20778603158669 0.514851485148515 19.4 19 4 hypoactivity 1.18329312602558e-18 2.94344165098864e-16 1.20716993995662 0.514588859416446 19.4 19 4 increased carcinoma incidence 0.00612340917710125 0.0435822040859495 1.20645879418934 0.514285714285714 19.4 19 4 decreased bone mineralization 0.00612340917710125 0.0435822040859495 1.20645879418934 0.514285714285714 19.4 19 4 enlarged spleen 1.60552073525396e-14 2.28213304511098e-12 1.20552788462592 0.513888888888889 19.4 19 4 increased bone mineral content 2.12640027628222e-06 5.90996724832629e-05 1.20522896871106 0.513761467889908 19.4 19 4 abnormal hepatocyte morphology 1.76700391624684e-06 5.02333970475887e-05 1.20464729449836 0.513513513513513 19.4 19 4 abnormal posture 5.05558454697661e-05 0.000898269040043166 1.20226970115396 0.5125 19.4 19 4 premature death 3.96645597899501e-40 3.28885308258336e-37 1.20155449014792 0.51219512195122 19.4 19 4 sparse hair 4.19038099602316e-05 0.000766439171147618 1.20155449014792 0.51219512195122 19.4 19 4 liver fibrosis 0.00337876095422832 0.028156341285236 1.20155449014792 0.51219512195122 19.4 19 4 abnormal cholesterol homeostasis 0.00337876095422832 0.028156341285236 1.20155449014792 0.51219512195122 19.4 19 4 kidney failure 0.00277598690623681 0.0238675535252177 1.2002238650204 0.511627906976744 19.4 19 4 abnormal rib morphology 1.92637876944247e-07 7.09906250220468e-06 1.199011517682 0.511111111111111 19.4 19 4 trabecula carnea hypoplasia 0.00228242127194734 0.0205707351955399 1.199011517682 0.511111111111111 19.4 19 4 abnormal myocardial trabeculae morphology 0.00228242127194734 0.0205707351955399 1.199011517682 0.511111111111111 19.4 19 4 abnormal cell migration 0.00228242127194734 0.0205707351955399 1.199011517682 0.511111111111111 19.4 19 4 small placenta 0.00228242127194734 0.0205707351955399 1.199011517682 0.511111111111111 19.4 19 4 cyanosis 6.50015824158211e-10 4.19977756517805e-08 1.19738242594602 0.510416666666667 19.4 19 4 increased circulating LDL cholesterol level 0.00154600285306237 0.0149346877553113 1.19688372439419 0.510204081632653 19.4 19 4 decreased circulating creatinine level 0.00154600285306237 0.0149346877553113 1.19688372439419 0.510204081632653 19.4 19 4 increased fluid intake 0.00154600285306237 0.0149346877553113 1.19688372439419 0.510204081632653 19.4 19 4 increased lung adenocarcinoma incidence 0.00127351540896314 0.0129830720483435 1.19594499206133 0.509803921568627 19.4 19 4 abnormal trophoblast layer morphology 0.00127351540896314 0.0129830720483435 1.19594499206133 0.509803921568627 19.4 19 4 cachexia 5.37155646516147e-06 0.000127907730489731 1.19550270471219 0.509615384615385 19.4 19 4 male infertility 2.82634574443893e-23 1.00436214847026e-20 1.19393315616705 0.508946322067594 19.4 19 4 increased macrophage cell number 0.000714041445148904 0.00800080222886441 1.19352405078185 0.508771929824561 19.4 19 4 decreased body length 3.58173077452632e-13 3.95980235628187e-11 1.19006934990493 0.507299270072993 19.4 19 4 thymus hypoplasia 2.30439479487189e-07 8.1307546840338e-06 1.18994526802089 0.507246376811594 19.4 19 4 atelectasis 0.000187744488785406 0.00283039039911332 1.18946641680639 0.507042253521127 19.4 19 4 corneal opacity 0.000187744488785406 0.00283039039911332 1.18946641680639 0.507042253521127 19.4 19 4 abnormal fertility/fecundity 0.000155328027621319 0.00239986626526727 1.18901380401461 0.506849315068493 19.4 19 4 spleen hyperplasia 0.00012854360811216 0.0020366383769363 1.18858533057172 0.506666666666667 19.4 19 4 neonatal lethality, complete penetrance 8.28531193705889e-21 2.42467216981576e-18 1.18837955056296 0.506578947368421 19.4 19 4 abnormal visceral yolk sac morphology 8.81011994555239e-05 0.0014482332783348 1.18779346825955 0.506329113924051 19.4 19 4 postnatal lethality 1.74745340668736e-08 8.27960066501868e-07 1.18707793002566 0.506024096385542 19.4 19 4 short tail 6.04389856873525e-05 0.00104404150623118 1.18707793002566 0.506024096385542 19.4 19 4 cardiac fibrosis 5.00753719494497e-05 0.000892921058955241 1.18674541519932 0.505882352941176 19.4 19 4 edema 1.00655819677473e-08 5.05820912015586e-07 1.18658495746335 0.505813953488372 19.4 19 4 abnormal muscle physiology 3.43949981985e-05 0.000664384957775269 1.18612521900637 0.50561797752809 19.4 19 4 abnormal CNS synaptic transmission 1.3489637395378e-05 0.000295642934105752 1.18479398980435 0.505050505050505 19.4 19 4 abnormal testis morphology 3.03940510630522e-06 7.97967354423632e-05 1.18314558077505 0.504347826086956 19.4 19 4 thrombocytopenia 1.89052639444073e-07 7.01893194950944e-06 1.1810353330091 0.503448275862069 19.4 19 4 abnormal glucose homeostasis 9.7189730188165e-09 4.93386640496042e-07 1.1729460499063 0.5 19.4 19 4 increased monocyte cell number 1.91850333763416e-05 0.000392780004309875 1.1729460499063 0.5 19.4 19 4 increased circulating creatinine level 7.13468048066693e-05 0.00120463027389743 1.1729460499063 0.5 19.4 19 4 abnormal excitatory postsynaptic currents 0.000151804546022666 0.00235273400767216 1.1729460499063 0.5 19.4 19 4 abnormal axial skeleton morphology 0.000183456345728218 0.00278260768292038 1.1729460499063 0.5 19.4 19 4 pale liver 0.00022176893340947 0.00320726873172126 1.1729460499063 0.5 19.4 19 4 abnormal digit morphology 0.000268160877714514 0.00364508296893363 1.1729460499063 0.5 19.4 19 4 abnormal eating behavior 0.000844265465187436 0.00933382375401665 1.1729460499063 0.5 19.4 19 4 abnormal eye development 0.00124146697310162 0.0128495267977083 1.1729460499063 0.5 19.4 19 4 increased cell proliferation 0.00150656465894924 0.0147642730589567 1.1729460499063 0.5 19.4 19 4 decreased oocyte number 0.00222240910261666 0.0201760680392662 1.1729460499063 0.5 19.4 19 4 lethality, incomplete penetrance 0.00400140121737026 0.031448611463534 1.1729460499063 0.5 19.4 19 4 abnormal frontal bone morphology 0.00725778590423884 0.0500103668609255 1.1729460499063 0.5 19.4 19 4 abnormal compact bone morphology 0.00725778590423884 0.0500103668609255 1.1729460499063 0.5 19.4 19 4 hyporesponsive to tactile stimuli 0.00725778590423884 0.0500103668609255 1.1729460499063 0.5 19.4 19 4 decreased threshold for auditory brainstem response 0.00725778590423884 0.0500103668609255 1.1729460499063 0.5 19.4 19 4 abnormal reflex 0.00886911818855018 0.057303718166282 1.1729460499063 0.5 19.4 19 4 abnormal heart atrium morphology 0.0132937143713126 0.0754979783073977 1.1729460499063 0.5 19.4 19 4 abnormal depression-related behavior 0.0132937143713126 0.0754979783073977 1.1729460499063 0.5 19.4 19 4 abnormal spongiotrophoblast layer morphology 0.0132937143713126 0.0754979783073977 1.1729460499063 0.5 19.4 19 4 increased metastatic potential 0.0163104181705255 0.0887700997462566 1.1729460499063 0.5 19.4 19 4 delayed eyelid opening 0.0163104181705255 0.0887700997462566 1.1729460499063 0.5 19.4 19 4 abnormal lactation 0.0163104181705255 0.0887700997462566 1.1729460499063 0.5 19.4 19 4 abnormal synaptic transmission 0.0163104181705255 0.0887700997462566 1.1729460499063 0.5 19.4 19 4 abnormal brain vasculature morphology 0.0163104181705255 0.0887700997462566 1.1729460499063 0.5 19.4 19 4 abnormal jaw morphology 0.0200453940676262 0.104974563669937 1.1729460499063 0.5 19.4 19 4 increased bone resorption 0.0200453940676262 0.104974563669937 1.1729460499063 0.5 19.4 19 4 abnormal digestive system morphology 0.0304601909804029 0.132338206806541 1.1729460499063 0.5 19.4 19 4 abnormal body weight 0.0304601909804029 0.132338206806541 1.1729460499063 0.5 19.4 19 4 increased stereotypic behavior 0.0304601909804029 0.132338206806541 1.1729460499063 0.5 19.4 19 4 prolonged QT interval 0.0304601909804029 0.132338206806541 1.1729460499063 0.5 19.4 19 4 increased body temperature 0.0304601909804029 0.132338206806541 1.1729460499063 0.5 19.4 19 4 abnormal truncus arteriosus septation 0.0304601909804029 0.132338206806541 1.1729460499063 0.5 19.4 19 4 intracerebral hemorrhage 0.0376859031799205 0.156252660961671 1.1729460499063 0.5 19.4 19 4 abnormal oogenesis 0.0376859031799205 0.156252660961671 1.1729460499063 0.5 19.4 19 4 increased skin papilloma incidence 0.0376859031799205 0.156252660961671 1.1729460499063 0.5 19.4 19 4 decreased cardiac output 0.0376859031799205 0.156252660961671 1.1729460499063 0.5 19.4 19 4 prolonged PR interval 0.0376859031799205 0.156252660961671 1.1729460499063 0.5 19.4 19 4 abnormal blood-brain barrier function 0.0376859031799205 0.156252660961671 1.1729460499063 0.5 19.4 19 4 decreased circulating estradiol level 0.0376859031799205 0.156252660961671 1.1729460499063 0.5 19.4 19 4 failure of palatal shelf elevation 0.0376859031799205 0.156252660961671 1.1729460499063 0.5 19.4 19 4 absent spleen 0.0582423584698152 0.215752593735913 1.1729460499063 0.5 19.4 19 4 abnormal thyroid cartilage morphology 0.0582423584698152 0.215752593735913 1.1729460499063 0.5 19.4 19 4 abnormal thymus medulla morphology 0.0582423584698152 0.215752593735913 1.1729460499063 0.5 19.4 19 4 acidosis 0.0582423584698152 0.215752593735913 1.1729460499063 0.5 19.4 19 4 abnormal redox activity 0.0582423584698152 0.215752593735913 1.1729460499063 0.5 19.4 19 4 absent ureter 0.0582423584698152 0.215752593735913 1.1729460499063 0.5 19.4 19 4 long tibia 0.0582423584698152 0.215752593735913 1.1729460499063 0.5 19.4 19 4 abnormal glycogen homeostasis 0.0582423584698152 0.215752593735913 1.1729460499063 0.5 19.4 19 4 decreased pulmonary respiratory rate 0.0582423584698152 0.215752593735913 1.1729460499063 0.5 19.4 19 4 increased gastrointestinal tumor incidence 0.0582423584698152 0.215752593735913 1.1729460499063 0.5 19.4 19 4 atrioventricular block 0.0582423584698152 0.215752593735913 1.1729460499063 0.5 19.4 19 4 primary atelectasis 0.0582423584698152 0.215752593735913 1.1729460499063 0.5 19.4 19 4 increased adipocyte glucose uptake 0.0582423584698152 0.215752593735913 1.1729460499063 0.5 19.4 19 4 failure of tooth eruption 0.0728521167731291 0.249613829852836 1.1729460499063 0.5 19.4 19 4 disorganized retinal layers 0.0728521167731291 0.249613829852836 1.1729460499063 0.5 19.4 19 4 small pancreas 0.0728521167731291 0.249613829852836 1.1729460499063 0.5 19.4 19 4 bowed tibia 0.0728521167731291 0.249613829852836 1.1729460499063 0.5 19.4 19 4 bowed radius 0.0728521167731291 0.249613829852836 1.1729460499063 0.5 19.4 19 4 small epididymis 0.0728521167731291 0.249613829852836 1.1729460499063 0.5 19.4 19 4 decreased creatinine clearance 0.0728521167731291 0.249613829852836 1.1729460499063 0.5 19.4 19 4 decreased skeletal muscle weight 0.0728521167731291 0.249613829852836 1.1729460499063 0.5 19.4 19 4 decreased fibroblast apoptosis 0.0728521167731291 0.249613829852836 1.1729460499063 0.5 19.4 19 4 abnormal interparietal bone morphology 0.091622463750415 0.268198752066031 1.1729460499063 0.5 19.4 19 4 midline facial cleft 0.091622463750415 0.268198752066031 1.1729460499063 0.5 19.4 19 4 abnormal blood flow velocity 0.091622463750415 0.268198752066031 1.1729460499063 0.5 19.4 19 4 megacephaly 0.091622463750415 0.268198752066031 1.1729460499063 0.5 19.4 19 4 abnormal ventral body wall morphology 0.091622463750415 0.268198752066031 1.1729460499063 0.5 19.4 19 4 failure of zygotic cell division 0.091622463750415 0.268198752066031 1.1729460499063 0.5 19.4 19 4 absent olfactory bulb 0.091622463750415 0.268198752066031 1.1729460499063 0.5 19.4 19 4 abnormal voluntary movement 0.091622463750415 0.268198752066031 1.1729460499063 0.5 19.4 19 4 skeletal muscle necrosis 0.091622463750415 0.268198752066031 1.1729460499063 0.5 19.4 19 4 decreased CNS synapse formation 0.091622463750415 0.268198752066031 1.1729460499063 0.5 19.4 19 4 decreased cornea thickness 0.091622463750415 0.268198752066031 1.1729460499063 0.5 19.4 19 4 abnormal renal reabsorbtion 0.091622463750415 0.268198752066031 1.1729460499063 0.5 19.4 19 4 increased lung compliance 0.091622463750415 0.268198752066031 1.1729460499063 0.5 19.4 19 4 abnormal mineral level 0.116032493383297 0.324304300326911 1.1729460499063 0.5 19.4 19 4 abnormal superior cervical ganglion morphology 0.116032493383297 0.324304300326911 1.1729460499063 0.5 19.4 19 4 abnormal mating frequency 0.116032493383297 0.324304300326911 1.1729460499063 0.5 19.4 19 4 abnormal respiratory function 0.116032493383297 0.324304300326911 1.1729460499063 0.5 19.4 19 4 increased growth rate 0.116032493383297 0.324304300326911 1.1729460499063 0.5 19.4 19 4 dilated bile duct 0.116032493383297 0.324304300326911 1.1729460499063 0.5 19.4 19 4 absent ovary 0.116032493383297 0.324304300326911 1.1729460499063 0.5 19.4 19 4 increased osteosarcoma incidence 0.116032493383297 0.324304300326911 1.1729460499063 0.5 19.4 19 4 delayed somite formation 0.116032493383297 0.324304300326911 1.1729460499063 0.5 19.4 19 4 decreased left ventricle systolic pressure 0.116032493383297 0.324304300326911 1.1729460499063 0.5 19.4 19 4 abnormal defecation 0.116032493383297 0.324304300326911 1.1729460499063 0.5 19.4 19 4 increased hepatocyte proliferation 0.116032493383297 0.324304300326911 1.1729460499063 0.5 19.4 19 4 vestibular saccular macula degeneration 0.116032493383297 0.324304300326911 1.1729460499063 0.5 19.4 19 4 bowed ulna 0.116032493383297 0.324304300326911 1.1729460499063 0.5 19.4 19 4 small parietal bone 0.116032493383297 0.324304300326911 1.1729460499063 0.5 19.4 19 4 reduced cerebellar foliation 0.116032493383297 0.324304300326911 1.1729460499063 0.5 19.4 19 4 impaired behavioral response to cocaine 0.116032493383297 0.324304300326911 1.1729460499063 0.5 19.4 19 4 decreased mammary gland epithelial cell proliferation 0.116032493383297 0.324304300326911 1.1729460499063 0.5 19.4 19 4 abnormal colon goblet cell morphology 0.116032493383297 0.324304300326911 1.1729460499063 0.5 19.4 19 4 decreased mean corpuscular hemoglobin 0.000392459430142784 0.00503217954886688 1.1729460499063 0.5 19.4 19 4 abnormal skin morphology 0.000475024310541316 0.00589338140883553 1.1729460499063 0.5 19.4 19 4 abnormal enzyme/coenzyme level 0.0010235376918751 0.0110457701021228 1.1729460499063 0.5 19.4 19 4 abnormal female meiosis 0.00182927078901192 0.0169156546009931 1.1729460499063 0.5 19.4 19 4 abnormal optic nerve morphology 0.0048754039480763 0.0360651770596456 1.1729460499063 0.5 19.4 19 4 short maxilla 0.0108511252930632 0.0645037451056882 1.1729460499063 0.5 19.4 19 4 enlarged liver sinusoidal spaces 0.0108511252930632 0.0645037451056882 1.1729460499063 0.5 19.4 19 4 abnormal vision 0.0108511252930632 0.0645037451056882 1.1729460499063 0.5 19.4 19 4 abnormal kidney cortex morphology 0.0246828813425956 0.122446066452502 1.1729460499063 0.5 19.4 19 4 decreased circulating glycerol level 0.0246828813425956 0.122446066452502 1.1729460499063 0.5 19.4 19 4 abnormal erythrocyte osmotic lysis 0.0246828813425956 0.122446066452502 1.1729460499063 0.5 19.4 19 4 pulmonary edema 0.0246828813425956 0.122446066452502 1.1729460499063 0.5 19.4 19 4 abnormal basioccipital bone morphology 0.0467659800586996 0.183776264448681 1.1729460499063 0.5 19.4 19 4 abnormal vascular regression 0.0467659800586996 0.183776264448681 1.1729460499063 0.5 19.4 19 4 increased urine glucose level 0.0467659800586996 0.183776264448681 1.1729460499063 0.5 19.4 19 4 abnormal hearing physiology 0.0467659800586996 0.183776264448681 1.1729460499063 0.5 19.4 19 4 decreased paired-pulse facilitation 0.0467659800586996 0.183776264448681 1.1729460499063 0.5 19.4 19 4 absent placental labyrinth 0.0467659800586996 0.183776264448681 1.1729460499063 0.5 19.4 19 4 abnormal heart right ventricle morphology 0.0467659800586996 0.183776264448681 1.1729460499063 0.5 19.4 19 4 dilated vasculature 0.0467659800586996 0.183776264448681 1.1729460499063 0.5 19.4 19 4 abnormal heart electrocardiography waveform feature 0.0467659800586996 0.183776264448681 1.1729460499063 0.5 19.4 19 4 abnormal otic capsule morphology 0.148310641399456 0.384895900345484 1.1729460499063 0.5 19.4 19 4 abnormal auchene hair morphology 0.148310641399456 0.384895900345484 1.1729460499063 0.5 19.4 19 4 retarded hair growth 0.148310641399456 0.384895900345484 1.1729460499063 0.5 19.4 19 4 kidney hemorrhage 0.148310641399456 0.384895900345484 1.1729460499063 0.5 19.4 19 4 abnormal prostate gland epithelium morphology 0.148310641399456 0.384895900345484 1.1729460499063 0.5 19.4 19 4 abnormal epidermis suprabasal layer morphology 0.148310641399456 0.384895900345484 1.1729460499063 0.5 19.4 19 4 abnormal immune cell physiology 0.148310641399456 0.384895900345484 1.1729460499063 0.5 19.4 19 4 abnormal PNS synaptic transmission 0.148310641399456 0.384895900345484 1.1729460499063 0.5 19.4 19 4 abnormal neuron specification 0.148310641399456 0.384895900345484 1.1729460499063 0.5 19.4 19 4 impaired social transmission of food preference 0.148310641399456 0.384895900345484 1.1729460499063 0.5 19.4 19 4 primary sex reversal 0.148310641399456 0.384895900345484 1.1729460499063 0.5 19.4 19 4 abnormal tibialis anterior morphology 0.148310641399456 0.384895900345484 1.1729460499063 0.5 19.4 19 4 aneurysm 0.148310641399456 0.384895900345484 1.1729460499063 0.5 19.4 19 4 absent seminal vesicle 0.148310641399456 0.384895900345484 1.1729460499063 0.5 19.4 19 4 increased atrioventricular cushion size 0.148310641399456 0.384895900345484 1.1729460499063 0.5 19.4 19 4 abnormal pillar cell morphology 0.148310641399456 0.384895900345484 1.1729460499063 0.5 19.4 19 4 absent pharyngeal arches 0.148310641399456 0.384895900345484 1.1729460499063 0.5 19.4 19 4 abnormal ear physiology 0.148310641399456 0.384895900345484 1.1729460499063 0.5 19.4 19 4 abnormal embryonic erythrocyte morphology 0.148310641399456 0.384895900345484 1.1729460499063 0.5 19.4 19 4 abnormal placental transport 0.148310641399456 0.384895900345484 1.1729460499063 0.5 19.4 19 4 abnormal deltoid tuberosity morphology 0.148310641399456 0.384895900345484 1.1729460499063 0.5 19.4 19 4 abnormal respiratory conducting tube morphology 0.148310641399456 0.384895900345484 1.1729460499063 0.5 19.4 19 4 abnormal gonadal fat pad morphology 0.148310641399456 0.384895900345484 1.1729460499063 0.5 19.4 19 4 increased platelet aggregation 0.148310641399456 0.384895900345484 1.1729460499063 0.5 19.4 19 4 absent inguinal lymph nodes 0.148310641399456 0.384895900345484 1.1729460499063 0.5 19.4 19 4 ventricular premature beat 0.148310641399456 0.384895900345484 1.1729460499063 0.5 19.4 19 4 abnormal sperm principal piece morphology 0.148310641399456 0.384895900345484 1.1729460499063 0.5 19.4 19 4 abnormal cerebellar granule cell migration 0.148310641399456 0.384895900345484 1.1729460499063 0.5 19.4 19 4 increased serotonin level 0.148310641399456 0.384895900345484 1.1729460499063 0.5 19.4 19 4 acanthocytosis 0.148310641399456 0.384895900345484 1.1729460499063 0.5 19.4 19 4 increased T-helper 17 cell number 0.148310641399456 0.384895900345484 1.1729460499063 0.5 19.4 19 4 abnormal heart and great artery attachment 0.148310641399456 0.384895900345484 1.1729460499063 0.5 19.4 19 4 abnormal inferior vena cava valve morphology 0.148310641399456 0.384895900345484 1.1729460499063 0.5 19.4 19 4 thick aortic valve cusps 0.148310641399456 0.384895900345484 1.1729460499063 0.5 19.4 19 4 thick aortic valve 0.148310641399456 0.384895900345484 1.1729460499063 0.5 19.4 19 4 abnormal vertebrae morphology 1.28013880768343e-05 0.000284861404093323 1.16218507697138 0.495412844036697 19.4 19 4 increased circulating HDL cholesterol level 1.85933889355527e-05 0.000383826182383297 1.16177513514529 0.495238095238095 19.4 19 4 decreased B cell number 2.53950483669204e-09 1.43568597301624e-07 1.16155822417906 0.495145631067961 19.4 19 4 abnormal myocardial fiber morphology 3.92943642483254e-05 0.000732170270170108 1.16085382258768 0.494845360824742 19.4 19 4 small ovary 6.89964994787322e-05 0.00117553967433799 1.16005653287437 0.494505494505495 19.4 19 4 polyuria 0.000258531774411508 0.00355302645772721 1.1577129843231 0.493506493506494 19.4 19 4 hyperactivity 2.47320609088452e-15 3.72854554610621e-13 1.15713815165959 0.493261455525606 19.4 19 4 abnormal skeletal muscle fiber morphology 0.000457176002484638 0.00570037747458916 1.15642568300621 0.492957746478873 19.4 19 4 decreased liver weight 0.000457176002484638 0.00570037747458916 1.15642568300621 0.492957746478873 19.4 19 4 microcephaly 0.000553199906086054 0.00663173381392318 1.15594683179172 0.492753623188406 19.4 19 4 maternal effect 0.000669625927584223 0.00764080043516401 1.15543939244501 0.492537313432836 19.4 19 4 abnormal lipid homeostasis 2.78733796263603e-06 7.41551142466002e-05 1.15490072606159 0.492307692307692 19.4 19 4 impaired glucose tolerance 1.25973330234497e-10 9.49571693813066e-09 1.15402756523039 0.491935483870968 19.4 19 4 abnormal kidney morphology 6.68729340650879e-08 2.84352860661378e-06 1.15283840333648 0.491428571428571 19.4 19 4 abnormal neuron differentiation 1.48331116601512e-05 0.000318080734953672 1.1520005847294 0.491071428571429 19.4 19 4 increased sensitivity to xenobiotic induced morbidity/mortality 1.78707730268179e-05 0.000371441557374851 1.15161975808982 0.490909090909091 19.4 19 4 abnormal head morphology 0.00212471696225821 0.0193598294637996 1.15161975808982 0.490909090909091 19.4 19 4 cochlear inner hair cell degeneration 0.00313480688497582 0.0266137615234722 1.14994710775128 0.490196078431373 19.4 19 4 cardiac hypertrophy 5.4809766835103e-05 0.000950099616740897 1.14900837541842 0.489795918367347 19.4 19 4 organ of Corti degeneration 0.00381127835515348 0.0304934354932458 1.14900837541842 0.489795918367347 19.4 19 4 abnormal respiratory system physiology 0.00381127835515348 0.0304934354932458 1.14900837541842 0.489795918367347 19.4 19 4 abnormal T-helper 1 physiology 0.00463692183741391 0.0345857363435296 1.14798975097213 0.48936170212766 19.4 19 4 increased circulating corticosterone level 0.00564564290429652 0.0408242346640627 1.14688058213061 0.488888888888889 19.4 19 4 albuminuria 0.00564564290429652 0.0408242346640627 1.14688058213061 0.488888888888889 19.4 19 4 abnormal suckling behavior 0.000140088332709516 0.00219163350701208 1.1462881851357 0.488636363636364 19.4 19 4 neonatal lethality, incomplete penetrance 9.65943148669911e-11 7.84444329678351e-09 1.14587806413923 0.488461538461538 19.4 19 4 abnormal organ of Corti morphology 0.0068793929425594 0.0482230739273872 1.1456682347922 0.488372093023256 19.4 19 4 abnormal blood circulation 0.0068793929425594 0.0482230739273872 1.1456682347922 0.488372093023256 19.4 19 4 decreased exploration in new environment 0.00020418407717797 0.0030232612617869 1.14501876300377 0.488095238095238 19.4 19 4 decreased anxiety-related response 8.11436270672716e-06 0.000187762578911477 1.14433760966469 0.48780487804878 19.4 19 4 abnormal developmental patterning 0.00024659156255205 0.00346551701609166 1.14433760966469 0.48780487804878 19.4 19 4 abnormal cornea morphology 0.000359922641380909 0.00466062850147957 1.14287051016512 0.487179487179487 19.4 19 4 increased circulating alanine transaminase level 0.000359922641380909 0.00466062850147957 1.14287051016512 0.487179487179487 19.4 19 4 abnormal heart looping 0.0102427612265945 0.0640172576662153 1.14287051016512 0.487179487179487 19.4 19 4 increased autoantibody level 0.0102427612265945 0.0640172576662153 1.14287051016512 0.487179487179487 19.4 19 4 impaired macrophage chemotaxis 0.0102427612265945 0.0640172576662153 1.14287051016512 0.487179487179487 19.4 19 4 increased hepatocyte apoptosis 0.0102427612265945 0.0640172576662153 1.14287051016512 0.487179487179487 19.4 19 4 small seminiferous tubules 0.000525899698811651 0.00638010025047831 1.14124480531424 0.486486486486487 19.4 19 4 increased circulating phosphate level 0.0125177650915119 0.0714992897018044 1.14124480531424 0.486486486486487 19.4 19 4 abnormal hair follicle development 0.0125177650915119 0.0714992897018044 1.14124480531424 0.486486486486487 19.4 19 4 abnormal seminiferous tubule morphology 1.46321007670557e-06 4.28204125388836e-05 1.14081054168969 0.486301369863014 19.4 19 4 decreased triglyceride level 0.015316190513694 0.0840976632844464 1.13943330562327 0.485714285714286 19.4 19 4 impaired adaptive thermogenesis 0.015316190513694 0.0840976632844464 1.13943330562327 0.485714285714286 19.4 19 4 spleen hypoplasia 4.32549665024831e-05 0.000788254426189938 1.13943330562327 0.485714285714286 19.4 19 4 abnormal aorta morphology 0.0187649008126696 0.0991033774342156 1.13740223021217 0.484848484848485 19.4 19 4 dextrocardia 0.0187649008126696 0.0991033774342156 1.13740223021217 0.484848484848485 19.4 19 4 abnormal ovarian folliculogenesis 0.0187649008126696 0.0991033774342156 1.13740223021217 0.484848484848485 19.4 19 4 abnormal epidermis stratum basale morphology 0.0187649008126696 0.0991033774342156 1.13740223021217 0.484848484848485 19.4 19 4 decreased brown adipose tissue amount 0.0187649008126696 0.0991033774342156 1.13740223021217 0.484848484848485 19.4 19 4 abnormal middle ear ossicle morphology 0.0187649008126696 0.0991033774342156 1.13740223021217 0.484848484848485 19.4 19 4 decreased lymphocyte cell number 7.71022671562412e-06 0.000180086281268686 1.13629148584673 0.484375 19.4 19 4 decreased eosinophil cell number 0.00136467167206531 0.0138412593350445 1.13629148584673 0.484375 19.4 19 4 increased lung adenoma incidence 0.0230239984265217 0.117001422034674 1.13510908055449 0.483870967741935 19.4 19 4 decreased double-negative T cell number 0.0230239984265217 0.117001422034674 1.13510908055449 0.483870967741935 19.4 19 4 abnormal podocyte morphology 0.0230239984265217 0.117001422034674 1.13510908055449 0.483870967741935 19.4 19 4 abnormal spermatogenesis 1.0081622365245e-07 4.07772937130845e-06 1.13469780914849 0.483695652173913 19.4 19 4 liver inflammation 1.61688255309133e-05 0.000337982802589469 1.13384784824276 0.483333333333333 19.4 19 4 increased circulating cholesterol level 2.09770895078274e-07 7.61759272273294e-06 1.13295925275041 0.482954545454545 19.4 19 4 increased blood urea nitrogen level 2.41220444362416e-06 6.59380060825836e-05 1.13249963439229 0.482758620689655 19.4 19 4 cochlear ganglion degeneration 0.00242939528775811 0.0212039325554327 1.13249963439229 0.482758620689655 19.4 19 4 decreased bone strength 0.0282965957084605 0.12759970321829 1.13249963439229 0.482758620689655 19.4 19 4 short mandible 0.00294705315905915 0.0252350937458163 1.13105511955251 0.482142857142857 19.4 19 4 diluted coat color 0.00357685226036073 0.0292678289396293 1.12950360361348 0.481481481481481 19.4 19 4 abnormal osteoblast physiology 0.00357685226036073 0.0292678289396293 1.12950360361348 0.481481481481481 19.4 19 4 abnormal trigeminal nerve morphology 0.0348419607639166 0.147270716993136 1.12950360361348 0.481481481481481 19.4 19 4 thin epidermis 0.0348419607639166 0.147270716993136 1.12950360361348 0.481481481481481 19.4 19 4 abnormal fetal cardiomyocyte proliferation 0.0348419607639166 0.147270716993136 1.12950360361348 0.481481481481481 19.4 19 4 decreased circulating fructosamine level 0.0348419607639166 0.147270716993136 1.12950360361348 0.481481481481481 19.4 19 4 decreased bone mineral density 2.82863161721073e-10 1.92925199121493e-08 1.12885033374441 0.481203007518797 19.4 19 4 female infertility 2.82863161721073e-10 1.92925199121493e-08 1.12885033374441 0.481203007518797 19.4 19 4 abnormal placenta labyrinth morphology 0.000495246510485805 0.00605368891810044 1.12840379484657 0.481012658227848 19.4 19 4 decreased cardiac muscle contractility 7.14303378491944e-05 0.00120463027389743 1.12783274029452 0.480769230769231 19.4 19 4 absent corpus luteum 0.00434363660346092 0.0325936532461811 1.12783274029452 0.480769230769231 19.4 19 4 increased body length 0.00527792689595669 0.0383323887699044 1.12602820791005 0.48 19.4 19 4 ruffled hair 0.0429934700929096 0.173755088312125 1.12602820791005 0.48 19.4 19 4 mandible hypoplasia 0.0429934700929096 0.173755088312125 1.12602820791005 0.48 19.4 19 4 spontaneous skin ulceration 0.0429934700929096 0.173755088312125 1.12602820791005 0.48 19.4 19 4 abnormal nest building behavior 0.0429934700929096 0.173755088312125 1.12602820791005 0.48 19.4 19 4 increased pre-B cell number 0.0429934700929096 0.173755088312125 1.12602820791005 0.48 19.4 19 4 abnormal energy expenditure 0.0429934700929096 0.173755088312125 1.12602820791005 0.48 19.4 19 4 decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 0.0429934700929096 0.173755088312125 1.12602820791005 0.48 19.4 19 4 decreased percent body fat/body weight 0.000873633213898275 0.00955236316295367 1.12474278758139 0.479452054794521 19.4 19 4 oligodactyly 0.00641727472040315 0.0454785494786406 1.12407329782687 0.479166666666667 19.4 19 4 enlarged heart 6.22900897451221e-09 3.36840430958676e-07 1.12238803051379 0.478448275862069 19.4 19 4 abnormal allantois morphology 0.0078079597689882 0.0524553584708635 1.12194839556255 0.478260869565217 19.4 19 4 abnormal lymphocyte physiology 0.0078079597689882 0.0524553584708635 1.12194839556255 0.478260869565217 19.4 19 4 abnormal postnatal growth 0.0531835655561733 0.204789658391612 1.12194839556255 0.478260869565217 19.4 19 4 dilated heart 0.0531835655561733 0.204789658391612 1.12194839556255 0.478260869565217 19.4 19 4 thin ventricular wall 0.000263764813422718 0.00359515053911787 1.12081511435491 0.477777777777778 19.4 19 4 decreased compact bone thickness 0.00154503861589888 0.0149346877553113 1.12042607752244 0.477611940298507 19.4 19 4 internal hemorrhage 0.00154503861589888 0.0149346877553113 1.12042607752244 0.477611940298507 19.4 19 4 abnormal renal glomerulus morphology 6.69734737831478e-05 0.00114499323735794 1.1191411852317 0.477064220183486 19.4 19 4 respiratory failure 3.08476166664299e-06 8.03491585944967e-05 1.11857106746031 0.47682119205298 19.4 19 4 decreased circulating glucose level 2.83086221826512e-10 1.92925199121493e-08 1.11829264973146 0.476702508960573 19.4 19 4 abnormal retina morphology 4.59878238486195e-08 2.02468516501666e-06 1.11709147610124 0.476190476190476 19.4 19 4 abnormal pancreas morphology 0.0115854696770097 0.06694275452163 1.11709147610124 0.476190476190476 19.4 19 4 abnormal spleen white pulp morphology 0.0115854696770097 0.06694275452163 1.11709147610124 0.476190476190476 19.4 19 4 abnormal eye pigmentation 0.0659791969563712 0.237859786128947 1.11709147610124 0.476190476190476 19.4 19 4 increased acute inflammation 0.0659791969563712 0.237859786128947 1.11709147610124 0.476190476190476 19.4 19 4 abnormal clavicle morphology 0.0659791969563712 0.237859786128947 1.11709147610124 0.476190476190476 19.4 19 4 abnormal retinal pigment epithelium morphology 0.00067381777436674 0.0076710375914749 1.11429874741099 0.475 19.4 19 4 increased anxiety-related response 9.2609156774933e-06 0.000212318228089996 1.11387682437145 0.474820143884892 19.4 19 4 postnatal lethality, complete penetrance 2.64911830085776e-13 3.06496826669009e-11 1.11217164317541 0.474093264248705 19.4 19 4 impaired righting response 0.00024571522278309 0.00346298366386932 1.11121204727965 0.473684210526316 19.4 19 4 increased bone marrow cell number 0.0172517463600576 0.0925862331621216 1.11121204727965 0.473684210526316 19.4 19 4 abnormal retinal outer nuclear layer morphology 0.0172517463600576 0.0925862331621216 1.11121204727965 0.473684210526316 19.4 19 4 unresponsive to tactile stimuli 0.0821334724707687 0.264575882010777 1.11121204727965 0.473684210526316 19.4 19 4 decreased tumor incidence 0.0821334724707687 0.264575882010777 1.11121204727965 0.473684210526316 19.4 19 4 maternal imprinting 0.0821334724707687 0.264575882010777 1.11121204727965 0.473684210526316 19.4 19 4 abnormal optic vesicle formation 0.0821334724707687 0.264575882010777 1.11121204727965 0.473684210526316 19.4 19 4 oliguria 0.0821334724707687 0.264575882010777 1.11121204727965 0.473684210526316 19.4 19 4 abnormal blastocyst morphology 0.0821334724707687 0.264575882010777 1.11121204727965 0.473684210526316 19.4 19 4 increased circulating VLDL cholesterol level 0.0821334724707687 0.264575882010777 1.11121204727965 0.473684210526316 19.4 19 4 decreased eye pigmentation 0.0821334724707687 0.264575882010777 1.11121204727965 0.473684210526316 19.4 19 4 increased liver cholesterol level 0.0821334724707687 0.264575882010777 1.11121204727965 0.473684210526316 19.4 19 4 decreased susceptibility to weight gain 0.0821334724707687 0.264575882010777 1.11121204727965 0.473684210526316 19.4 19 4 right-sided stomach 0.0821334724707687 0.264575882010777 1.11121204727965 0.473684210526316 19.4 19 4 absent vitelline blood vessels 0.00402376612971721 0.0314567972161851 1.11121204727965 0.473684210526316 19.4 19 4 decreased circulating calcium level 0.00487876666555607 0.0360651770596456 1.10896717445687 0.472727272727273 19.4 19 4 abnormal joint morphology 0.00487876666555607 0.0360651770596456 1.10896717445687 0.472727272727273 19.4 19 4 cochlear outer hair cell degeneration 0.00143213802661393 0.0142574947703554 1.10778238046706 0.472222222222222 19.4 19 4 lung inflammation 1.79187886974803e-05 0.000371441557374851 1.10394922344123 0.470588235294118 19.4 19 4 abnormal spleen red pulp morphology 0.0257993679412086 0.12316504975042 1.10394922344123 0.470588235294118 19.4 19 4 decreased osteoblast cell number 0.0257993679412086 0.12316504975042 1.10394922344123 0.470588235294118 19.4 19 4 abnormal skin physiology 0.0257993679412086 0.12316504975042 1.10394922344123 0.470588235294118 19.4 19 4 abnormal vagus nerve morphology 0.102663338701905 0.292525836221063 1.10394922344123 0.470588235294118 19.4 19 4 increased incidence of corneal inflammation 0.102663338701905 0.292525836221063 1.10394922344123 0.470588235294118 19.4 19 4 abnormal heart rate 0.102663338701905 0.292525836221063 1.10394922344123 0.470588235294118 19.4 19 4 increased circulating magnesium level 0.102663338701905 0.292525836221063 1.10394922344123 0.470588235294118 19.4 19 4 increased hepatoma incidence 0.102663338701905 0.292525836221063 1.10394922344123 0.470588235294118 19.4 19 4 abnormal electroretinogram waveform feature 0.102663338701905 0.292525836221063 1.10394922344123 0.470588235294118 19.4 19 4 delayed heart development 0.102663338701905 0.292525836221063 1.10394922344123 0.470588235294118 19.4 19 4 decreased grip strength 6.43042272679907e-08 2.75787526429529e-06 1.10331911543698 0.470319634703196 19.4 19 4 enlarged liver 0.000227675856642576 0.00328315184578786 1.10256928691192 0.47 19.4 19 4 abnormal tail morphology 0.00252743418128397 0.0220209895829908 1.10185841051804 0.46969696969697 19.4 19 4 decreased circulating LDL cholesterol level 0.00305599839599866 0.026123010343803 1.09963692178716 0.46875 19.4 19 4 abnormal vertebral body morphology 0.0316095431811179 0.135240964259436 1.09963692178716 0.46875 19.4 19 4 increased circulating insulin level 4.30361225639939e-06 0.000108133691795894 1.09963692178716 0.46875 19.4 19 4 cleft secondary palate 0.000396763488214749 0.00505359312008157 1.09807715310377 0.468085106382979 19.4 19 4 abnormal tibia morphology 0.0105984731487736 0.0645037451056882 1.09807715310377 0.468085106382979 19.4 19 4 increased respiratory quotient 0.0105984731487736 0.0645037451056882 1.09807715310377 0.468085106382979 19.4 19 4 no abnormal phenotype detected 1.94548847293412e-52 3.22626838428241e-49 1.09790454469616 0.468011527377522 19.4 19 4 increased sensitivity to induced morbidity/mortality 1.03881258014951e-06 3.11330878689386e-05 1.09644956839067 0.467391304347826 19.4 19 4 altered response to myocardial infarction 0.0128859209294884 0.0734335127425024 1.09474964657922 0.466666666666667 19.4 19 4 abnormal ovarian follicle morphology 0.0128859209294884 0.0734335127425024 1.09474964657922 0.466666666666667 19.4 19 4 abnormal kidney development 0.00447199442918213 0.0334558981732046 1.09474964657922 0.466666666666667 19.4 19 4 abnormal incisor morphology 0.00447199442918213 0.0334558981732046 1.09474964657922 0.466666666666667 19.4 19 4 abnormal heart tube morphology 0.0387845010541537 0.159861551569523 1.09474964657922 0.466666666666667 19.4 19 4 abnormal response to new environment 0.0387845010541537 0.159861551569523 1.09474964657922 0.466666666666667 19.4 19 4 emphysema 0.0387845010541537 0.159861551569523 1.09474964657922 0.466666666666667 19.4 19 4 decreased chondrocyte number 0.128971035905878 0.346827515476618 1.09474964657922 0.466666666666667 19.4 19 4 decreased hepatocyte number 0.128971035905878 0.346827515476618 1.09474964657922 0.466666666666667 19.4 19 4 abnormal enteric neuron morphology 0.128971035905878 0.346827515476618 1.09474964657922 0.466666666666667 19.4 19 4 abnormal prostate gland morphology 0.128971035905878 0.346827515476618 1.09474964657922 0.466666666666667 19.4 19 4 hyperpigmentation 0.128971035905878 0.346827515476618 1.09474964657922 0.466666666666667 19.4 19 4 abnormal epidermis stratum spinosum morphology 0.128971035905878 0.346827515476618 1.09474964657922 0.466666666666667 19.4 19 4 abnormal pup retrieval 0.128971035905878 0.346827515476618 1.09474964657922 0.466666666666667 19.4 19 4 no suckling reflex 0.128971035905878 0.346827515476618 1.09474964657922 0.466666666666667 19.4 19 4 abnormal seizure response to electrical stimulation 0.128971035905878 0.346827515476618 1.09474964657922 0.466666666666667 19.4 19 4 increased airway responsiveness 0.128971035905878 0.346827515476618 1.09474964657922 0.466666666666667 19.4 19 4 abnormal bronchus morphology 0.128971035905878 0.346827515476618 1.09474964657922 0.466666666666667 19.4 19 4 abnormal lymph node B cell domain morphology 0.128971035905878 0.346827515476618 1.09474964657922 0.466666666666667 19.4 19 4 abnormal glial cell morphology 0.128971035905878 0.346827515476618 1.09474964657922 0.466666666666667 19.4 19 4 abnormal rostral migratory stream morphology 0.128971035905878 0.346827515476618 1.09474964657922 0.466666666666667 19.4 19 4 abnormal trophectoderm morphology 0.128971035905878 0.346827515476618 1.09474964657922 0.466666666666667 19.4 19 4 abnormal dendritic cell morphology 0.128971035905878 0.346827515476618 1.09474964657922 0.466666666666667 19.4 19 4 abnormal Muller cell morphology 0.128971035905878 0.346827515476618 1.09474964657922 0.466666666666667 19.4 19 4 liver vascular congestion 0.128971035905878 0.346827515476618 1.09474964657922 0.466666666666667 19.4 19 4 herniated liver 0.128971035905878 0.346827515476618 1.09474964657922 0.466666666666667 19.4 19 4 decreased hematocrit 1.53142257308541e-05 0.000325590910303416 1.09260727936477 0.465753424657534 19.4 19 4 abnormal spermiogenesis 0.0054124117017461 0.0392518195571237 1.09205321887828 0.46551724137931 19.4 19 4 abnormal axon guidance 0.0156777103156621 0.0858993489211664 1.091112604564 0.465116279069767 19.4 19 4 decreased circulating cholesterol level 1.6458044537892e-06 4.7220721761925e-05 1.08962201357416 0.46448087431694 19.4 19 4 abnormal nervous system electrophysiology 0.00100308678756549 0.0108959754762845 1.08916418919871 0.464285714285714 19.4 19 4 abnormal seminal vesicle morphology 0.00655291837118679 0.0463079103645657 1.08916418919871 0.464285714285714 19.4 19 4 rib bifurcation 0.0476656519007017 0.186281711080904 1.08916418919871 0.464285714285714 19.4 19 4 abnormal circulating cholesterol level 0.0476656519007017 0.186281711080904 1.08916418919871 0.464285714285714 19.4 19 4 myoclonus 0.0476656519007017 0.186281711080904 1.08916418919871 0.464285714285714 19.4 19 4 abnormal respiration 0.0476656519007017 0.186281711080904 1.08916418919871 0.464285714285714 19.4 19 4 abnormal hormone level 0.0476656519007017 0.186281711080904 1.08916418919871 0.464285714285714 19.4 19 4 decreased circulating progesterone level 0.0476656519007017 0.186281711080904 1.08916418919871 0.464285714285714 19.4 19 4 corneal vascularization 0.0476656519007017 0.186281711080904 1.08916418919871 0.464285714285714 19.4 19 4 Leydig cell hyperplasia 0.0190883537310585 0.100385369780144 1.08712072918145 0.463414634146341 19.4 19 4 short ulna 0.0190883537310585 0.100385369780144 1.08712072918145 0.463414634146341 19.4 19 4 hemopericardium 0.0190883537310585 0.100385369780144 1.08712072918145 0.463414634146341 19.4 19 4 increased bone trabecula number 0.0190883537310585 0.100385369780144 1.08712072918145 0.463414634146341 19.4 19 4 increased inflammatory response 0.000527079638783234 0.00638010025047831 1.086518446229 0.463157894736842 19.4 19 4 abnormal cochlea morphology 0.00793673370231911 0.0524553584708635 1.08606115732065 0.462962962962963 19.4 19 4 abnormal small intestine morphology 0.00793673370231911 0.0524553584708635 1.08606115732065 0.462962962962963 19.4 19 4 abnormal neuronal precursor proliferation 0.00793673370231911 0.0524553584708635 1.08606115732065 0.462962962962963 19.4 19 4 decreased platelet aggregation 0.00793673370231911 0.0524553584708635 1.08606115732065 0.462962962962963 19.4 19 4 cataract 0.000102350785758749 0.00165323103620057 1.08570212883889 0.462809917355372 19.4 19 4 increased urine protein level 0.00175202285341414 0.0163533089976273 1.08271943068274 0.461538461538462 19.4 19 4 abnormal B cell differentiation 0.000761871823989789 0.0084605185811366 1.08271943068274 0.461538461538462 19.4 19 4 abnormal skin condition 0.00961659605368331 0.0611797511087909 1.08271943068274 0.461538461538462 19.4 19 4 abnormal xiphoid process morphology 0.0586882604503216 0.216277107955815 1.08271943068274 0.461538461538462 19.4 19 4 small seminal vesicle 0.0586882604503216 0.216277107955815 1.08271943068274 0.461538461538462 19.4 19 4 no spontaneous movement 0.0586882604503216 0.216277107955815 1.08271943068274 0.461538461538462 19.4 19 4 abnormal renal/urinary system morphology 0.163043426759072 0.405570524063192 1.08271943068274 0.461538461538462 19.4 19 4 uterus hypoplasia 0.163043426759072 0.405570524063192 1.08271943068274 0.461538461538462 19.4 19 4 tight skin 0.163043426759072 0.405570524063192 1.08271943068274 0.461538461538462 19.4 19 4 excessive scratching 0.163043426759072 0.405570524063192 1.08271943068274 0.461538461538462 19.4 19 4 dystrophic cardiac calcinosis 0.163043426759072 0.405570524063192 1.08271943068274 0.461538461538462 19.4 19 4 abnormal dopaminergic neuron morphology 0.163043426759072 0.405570524063192 1.08271943068274 0.461538461538462 19.4 19 4 tracheoesophageal fistula 0.163043426759072 0.405570524063192 1.08271943068274 0.461538461538462 19.4 19 4 abnormal afterhyperpolarization 0.163043426759072 0.405570524063192 1.08271943068274 0.461538461538462 19.4 19 4 abnormal retinal inner plexiform layer morphology 0.163043426759072 0.405570524063192 1.08271943068274 0.461538461538462 19.4 19 4 increased heart weight 4.16098210096233e-05 0.000766439171147618 1.08012298120868 0.460431654676259 19.4 19 4 decreased susceptibility to hepatic steatosis 0.00491851235279308 0.0363050429601566 1.07985509356453 0.46031746031746 19.4 19 4 kidney inflammation 0.0116569126392865 0.0671994674165123 1.0791103659138 0.46 19.4 19 4 abnormal circulating protein level 0.0116569126392865 0.0671994674165123 1.0791103659138 0.46 19.4 19 4 abnormal intestine morphology 0.0025423768775758 0.0221124562341602 1.07784231613012 0.459459459459459 19.4 19 4 skin inflammation 0.028366453418642 0.127713217880311 1.07784231613012 0.459459459459459 19.4 19 4 abnormal long bone morphology 0.00594103580946544 0.042466455678291 1.07680293106152 0.459016393442623 19.4 19 4 abnormal phalanx morphology 0.0141364102804717 0.0788437681001643 1.07520054574744 0.458333333333333 19.4 19 4 decreased metastatic potential 0.0724110363510562 0.249613829852836 1.07520054574744 0.458333333333333 19.4 19 4 hemolytic anemia 0.0724110363510562 0.249613829852836 1.07520054574744 0.458333333333333 19.4 19 4 abnormal primitive streak formation 0.0724110363510562 0.249613829852836 1.07520054574744 0.458333333333333 19.4 19 4 abnormal impulse conducting system conduction 0.0724110363510562 0.249613829852836 1.07520054574744 0.458333333333333 19.4 19 4 increased circulating total protein level 0.0724110363510562 0.249613829852836 1.07520054574744 0.458333333333333 19.4 19 4 abnormal liver morphology 4.84831001558692e-06 0.000117089040424975 1.0746544814784 0.458100558659218 19.4 19 4 syndactyly 0.00717780826581705 0.0497348135410026 1.07354384228712 0.457627118644068 19.4 19 4 increased circulating serum albumin level 0.0346273068275366 0.147114305266434 1.07240781705719 0.457142857142857 19.4 19 4 increased red blood cell distribution width 0.0346273068275366 0.147114305266434 1.07240781705719 0.457142857142857 19.4 19 4 reduced female fertility 2.57444671938762e-07 9.01962847109395e-06 1.07183001112128 0.456896551724138 19.4 19 4 increased T cell number 0.00144268199079499 0.0142690713801294 1.06631459082391 0.454545454545455 19.4 19 4 abnormal platelet physiology 0.0104850395662882 0.0645037451056882 1.06631459082391 0.454545454545455 19.4 19 4 renal interstitial fibrosis 0.0208198651472707 0.107446918161485 1.06631459082391 0.454545454545455 19.4 19 4 cochlear hair cell degeneration 0.0208198651472707 0.107446918161485 1.06631459082391 0.454545454545455 19.4 19 4 abnormal facial nerve morphology 0.0895569417700802 0.264575882010777 1.06631459082391 0.454545454545455 19.4 19 4 abnormal chorion morphology 0.0895569417700802 0.264575882010777 1.06631459082391 0.454545454545455 19.4 19 4 parakeratosis 0.0895569417700802 0.264575882010777 1.06631459082391 0.454545454545455 19.4 19 4 abnormal circulating lipid level 0.0895569417700802 0.264575882010777 1.06631459082391 0.454545454545455 19.4 19 4 abnormal temporal bone morphology 0.0895569417700802 0.264575882010777 1.06631459082391 0.454545454545455 19.4 19 4 pulmonary vascular congestion 0.0895569417700802 0.264575882010777 1.06631459082391 0.454545454545455 19.4 19 4 rough coat 0.0895569417700802 0.264575882010777 1.06631459082391 0.454545454545455 19.4 19 4 decreased atrioventricular cushion size 0.207799839351285 0.472978234387655 1.06631459082391 0.454545454545455 19.4 19 4 enlarged cranium 0.207799839351285 0.472978234387655 1.06631459082391 0.454545454545455 19.4 19 4 abnormal food preference 0.207799839351285 0.472978234387655 1.06631459082391 0.454545454545455 19.4 19 4 abnormal larynx morphology 0.207799839351285 0.472978234387655 1.06631459082391 0.454545454545455 19.4 19 4 fatigue 0.207799839351285 0.472978234387655 1.06631459082391 0.454545454545455 19.4 19 4 loss of cortex neurons 0.207799839351285 0.472978234387655 1.06631459082391 0.454545454545455 19.4 19 4 rectal hemorrhage 0.207799839351285 0.472978234387655 1.06631459082391 0.454545454545455 19.4 19 4 abnormal nerve fiber response 0.207799839351285 0.472978234387655 1.06631459082391 0.454545454545455 19.4 19 4 abnormal lymph circulation 0.207799839351285 0.472978234387655 1.06631459082391 0.454545454545455 19.4 19 4 dilated renal glomerular capsule 0.207799839351285 0.472978234387655 1.06631459082391 0.454545454545455 19.4 19 4 pharyngeal arch hypoplasia 0.207799839351285 0.472978234387655 1.06631459082391 0.454545454545455 19.4 19 4 abnormal crista ampullaris neuroepithelium morphology 0.207799839351285 0.472978234387655 1.06631459082391 0.454545454545455 19.4 19 4 increased circulating triiodothyronine level 0.207799839351285 0.472978234387655 1.06631459082391 0.454545454545455 19.4 19 4 enhanced behavioral response to addictive substance 0.207799839351285 0.472978234387655 1.06631459082391 0.454545454545455 19.4 19 4 palatal shelf hypoplasia 0.207799839351285 0.472978234387655 1.06631459082391 0.454545454545455 19.4 19 4 shortened PR interval 0.207799839351285 0.472978234387655 1.06631459082391 0.454545454545455 19.4 19 4 abnormal phrenic nerve innervation pattern to diaphragm 0.207799839351285 0.472978234387655 1.06631459082391 0.454545454545455 19.4 19 4 chylous ascites 0.207799839351285 0.472978234387655 1.06631459082391 0.454545454545455 19.4 19 4 dilated heart atrium 0.0423134118214917 0.172125285210074 1.06631459082391 0.454545454545455 19.4 19 4 single kidney 0.0423134118214917 0.172125285210074 1.06631459082391 0.454545454545455 19.4 19 4 abnormal osteoclast physiology 0.00646173820270844 0.0457285171528798 1.06298235772759 0.453125 19.4 19 4 alopecia 0.00108676004185849 0.0115034706558426 1.06182484517834 0.452631578947368 19.4 19 4 decreased birth weight 0.00108676004185849 0.0115034706558426 1.06182484517834 0.452631578947368 19.4 19 4 abnormal enzyme/coenzyme activity 3.4211054639905e-05 0.000664384957775269 1.06088114067959 0.452229299363057 19.4 19 4 osteopetrosis 0.0517637385122038 0.199786345305053 1.05943514185085 0.451612903225806 19.4 19 4 abnormal capillary morphology 0.0517637385122038 0.199786345305053 1.05943514185085 0.451612903225806 19.4 19 4 abnormal retinal photoreceptor layer morphology 0.0517637385122038 0.199786345305053 1.05943514185085 0.451612903225806 19.4 19 4 impaired hematopoiesis 0.0153319759997976 0.0840976632844464 1.05795133913117 0.450980392156863 19.4 19 4 abnormal cervical vertebrae morphology 0.0153319759997976 0.0840976632844464 1.05795133913117 0.450980392156863 19.4 19 4 increased thermal nociceptive threshold 0.00156208601448621 0.0150608099264901 1.05694039661887 0.450549450549451 19.4 19 4 abnormal female reproductive system morphology 0.0307284456617783 0.132338206806541 1.05565144491567 0.45 19.4 19 4 impaired ovarian folliculogenesis 0.0307284456617783 0.132338206806541 1.05565144491567 0.45 19.4 19 4 abnormal cell proliferation 0.111070511717007 0.3141420101149 1.05565144491567 0.45 19.4 19 4 brain inflammation 0.111070511717007 0.3141420101149 1.05565144491567 0.45 19.4 19 4 abnormal lens epithelium morphology 0.111070511717007 0.3141420101149 1.05565144491567 0.45 19.4 19 4 abnormal physiological neovascularization 0.111070511717007 0.3141420101149 1.05565144491567 0.45 19.4 19 4 abnormal thymocyte activation 0.111070511717007 0.3141420101149 1.05565144491567 0.45 19.4 19 4 decreased circulating VLDL cholesterol level 0.111070511717007 0.3141420101149 1.05565144491567 0.45 19.4 19 4 abnormal epidermis stratum corneum morphology 0.0185476800519002 0.0985840900194484 1.05325767746688 0.448979591836735 19.4 19 4 decreased urine osmolality 0.0185476800519002 0.0985840900194484 1.05325767746688 0.448979591836735 19.4 19 4 abnormal heart ventricle morphology 0.0035987666836297 0.0293505971328815 1.05264389094155 0.448717948717949 19.4 19 4 absent gastric milk in neonates 0.0035987666836297 0.0293505971328815 1.05264389094155 0.448717948717949 19.4 19 4 increased T cell proliferation 0.000738008082046477 0.00821384834045017 1.05236281113089 0.448598130841121 19.4 19 4 abnormal spleen morphology 2.12755700038131e-05 0.000430268133207196 1.05160680336427 0.448275862068966 19.4 19 4 decreased granulocyte number 0.0634030100568975 0.229070424860614 1.05160680336427 0.448275862068966 19.4 19 4 abnormal spinal nerve morphology 0.0634030100568975 0.229070424860614 1.05160680336427 0.448275862068966 19.4 19 4 increased double-positive T cell number 0.0634030100568975 0.229070424860614 1.05160680336427 0.448275862068966 19.4 19 4 polychromatophilia 0.0634030100568975 0.229070424860614 1.05160680336427 0.448275862068966 19.4 19 4 increased retinal apoptosis 0.0634030100568975 0.229070424860614 1.05160680336427 0.448275862068966 19.4 19 4 abnormal femur morphology 0.0069721700428359 0.0483955487769466 1.05039944767729 0.447761194029851 19.4 19 4 decreased T cell number 4.7467952761434e-05 0.000852538140751386 1.0490946036429 0.447204968944099 19.4 19 4 reduced male fertility 2.1751598646734e-06 6.01190018152787e-05 1.04376696952015 0.444933920704846 19.4 19 4 increased B cell number 0.000596283669168864 0.00696364144158474 1.04261871102782 0.444444444444444 19.4 19 4 decreased insulin secretion 0.00240942965994424 0.0211782907389091 1.04261871102782 0.444444444444444 19.4 19 4 increased exploration in new environment 0.00386363067608745 0.0308532305193179 1.04261871102782 0.444444444444444 19.4 19 4 abnormal hair follicle morphology 0.0100866629317649 0.0640172576662153 1.04261871102782 0.444444444444444 19.4 19 4 abnormal maxilla morphology 0.0164697163629851 0.0893531503880596 1.04261871102782 0.444444444444444 19.4 19 4 abnormal mandible morphology 0.0164697163629851 0.0893531503880596 1.04261871102782 0.444444444444444 19.4 19 4 abnormal ectoderm development 0.0271670205214965 0.12502860970809 1.04261871102782 0.444444444444444 19.4 19 4 decreased osteoclast cell number 0.0271670205214965 0.12502860970809 1.04261871102782 0.444444444444444 19.4 19 4 wrinkled skin 0.0777653001994455 0.262827695986577 1.04261871102782 0.444444444444444 19.4 19 4 abnormal type II pneumocyte morphology 0.0777653001994455 0.262827695986577 1.04261871102782 0.444444444444444 19.4 19 4 abnormal palate morphology 0.0777653001994455 0.262827695986577 1.04261871102782 0.444444444444444 19.4 19 4 abnormal skin appearance 0.0777653001994455 0.262827695986577 1.04261871102782 0.444444444444444 19.4 19 4 abnormal bone trabecula morphology 0.0777653001994455 0.262827695986577 1.04261871102782 0.444444444444444 19.4 19 4 lowered ear position 0.138200122887576 0.367278638550049 1.04261871102782 0.444444444444444 19.4 19 4 cortical renal glomerulopathies 0.138200122887576 0.367278638550049 1.04261871102782 0.444444444444444 19.4 19 4 right pulmonary isomerism 0.138200122887576 0.367278638550049 1.04261871102782 0.444444444444444 19.4 19 4 abnormal mammary gland morphology 0.138200122887576 0.367278638550049 1.04261871102782 0.444444444444444 19.4 19 4 abnormal phrenic nerve morphology 0.138200122887576 0.367278638550049 1.04261871102782 0.444444444444444 19.4 19 4 eye inflammation 0.138200122887576 0.367278638550049 1.04261871102782 0.444444444444444 19.4 19 4 abnormal body wall morphology 0.138200122887576 0.367278638550049 1.04261871102782 0.444444444444444 19.4 19 4 abnormal neutrophil morphology 0.138200122887576 0.367278638550049 1.04261871102782 0.444444444444444 19.4 19 4 increased susceptibility to autoimmune disorder 0.138200122887576 0.367278638550049 1.04261871102782 0.444444444444444 19.4 19 4 decreased food intake 0.00462922866959967 0.0345801991460336 1.0393192847271 0.443037974683544 19.4 19 4 abnormal male meiosis 0.0121318542974989 0.0696951213972945 1.03834568352361 0.442622950819672 19.4 19 4 decreased kidney weight 0.0198648635432676 0.104358707632266 1.03760612107096 0.442307692307692 19.4 19 4 decreased oxygen consumption 0.0328932585221567 0.139986279852634 1.0365569743358 0.441860465116279 19.4 19 4 abnormal oocyte morphology 0.0553508148848731 0.212641161430304 1.03495239697615 0.441176470588235 19.4 19 4 increased susceptibility to viral infection induced morbidity/mortality 0.0553508148848731 0.212641161430304 1.03495239697615 0.441176470588235 19.4 19 4 abnormal colon morphology 0.0145912317639137 0.0811076849446602 1.03378295923945 0.440677966101695 19.4 19 4 abnormal axon extension 0.0239618544475254 0.121395342033034 1.03219252391755 0.44 19.4 19 4 abnormal inner ear vestibule morphology 0.0955248384110285 0.279058174453827 1.03219252391755 0.44 19.4 19 4 decreased placenta weight 0.0955248384110285 0.279058174453827 1.03219252391755 0.44 19.4 19 4 abnormal vertebrae development 0.0955248384110285 0.279058174453827 1.03219252391755 0.44 19.4 19 4 weight loss 5.22228308827156e-05 0.000924585706909289 1.03219252391755 0.44 19.4 19 4 infertility 0.00143864570346098 0.0142574947703554 1.03043858589899 0.439252336448598 19.4 19 4 abnormal mammary gland development 0.0398380828249504 0.162454477093548 1.02990384869822 0.439024390243902 19.4 19 4 short humerus 0.0398380828249504 0.162454477093548 1.02990384869822 0.439024390243902 19.4 19 4 abnormal blood homeostasis 0.00107748149186527 0.011459931110391 1.02890004377746 0.43859649122807 19.4 19 4 decreased litter size 5.32819502372395e-07 1.68839300910998e-05 1.02684956682189 0.437722419928826 19.4 19 4 abnormal cardiovascular system morphology 0.0289057495547272 0.12990614637287 1.02632779366801 0.4375 19.4 19 4 abnormal kidney physiology 0.0289057495547272 0.12990614637287 1.02632779366801 0.4375 19.4 19 4 abnormal long term potentiation 0.067439223769715 0.241670566318497 1.02632779366801 0.4375 19.4 19 4 abnormal serotonin level 0.067439223769715 0.241670566318497 1.02632779366801 0.4375 19.4 19 4 decreased mast cell number 0.172619084120239 0.427041244902133 1.02632779366801 0.4375 19.4 19 4 reduced male mating frequency 0.172619084120239 0.427041244902133 1.02632779366801 0.4375 19.4 19 4 abnormal meiosis 0.172619084120239 0.427041244902133 1.02632779366801 0.4375 19.4 19 4 abnormal epicardium morphology 0.172619084120239 0.427041244902133 1.02632779366801 0.4375 19.4 19 4 paternal imprinting 0.172619084120239 0.427041244902133 1.02632779366801 0.4375 19.4 19 4 impaired muscle relaxation 0.172619084120239 0.427041244902133 1.02632779366801 0.4375 19.4 19 4 loose skin 0.172619084120239 0.427041244902133 1.02632779366801 0.4375 19.4 19 4 decreased circulating triiodothyronine level 0.172619084120239 0.427041244902133 1.02632779366801 0.4375 19.4 19 4 dilated respiratory conducting tubes 0.172619084120239 0.427041244902133 1.02632779366801 0.4375 19.4 19 4 abnormal pulmonary alveolus wall morphology 0.172619084120239 0.427041244902133 1.02632779366801 0.4375 19.4 19 4 embryonic lethality between somite formation and embryo turning, incomplete penetrance 0.172619084120239 0.427041244902133 1.02632779366801 0.4375 19.4 19 4 increased circulating free fatty acid level 0.00952502836980847 0.0606747965938504 1.0242627478055 0.436619718309859 19.4 19 4 increased circulating calcium level 0.0211030145281696 0.108251567779903 1.02366200719095 0.436363636363636 19.4 19 4 abnormal learning/memory/conditioning 0.0211030145281696 0.108251567779903 1.02366200719095 0.436363636363636 19.4 19 4 abnormal T-helper 2 physiology 0.0211030145281696 0.108251567779903 1.02366200719095 0.436363636363636 19.4 19 4 acanthosis 0.0482631022258199 0.188320732214474 1.02256835120037 0.435897435897436 19.4 19 4 abnormal response to injury 0.0482631022258199 0.188320732214474 1.02256835120037 0.435897435897436 19.4 19 4 abnormal forelimb morphology 0.0348713376116411 0.147270716993136 1.01995308687505 0.434782608695652 19.4 19 4 abnormal immune system morphology 0.0348713376116411 0.147270716993136 1.01995308687505 0.434782608695652 19.4 19 4 delayed wound healing 0.0348713376116411 0.147270716993136 1.01995308687505 0.434782608695652 19.4 19 4 abnormal pulmonary artery morphology 0.117536461934624 0.326307978864259 1.01995308687505 0.434782608695652 19.4 19 4 abnormal carpal bone morphology 0.117536461934624 0.326307978864259 1.01995308687505 0.434782608695652 19.4 19 4 abnormal innervation pattern to muscle 0.117536461934624 0.326307978864259 1.01995308687505 0.434782608695652 19.4 19 4 pancreas inflammation 0.117536461934624 0.326307978864259 1.01995308687505 0.434782608695652 19.4 19 4 abnormal cochlear ganglion morphology 0.117536461934624 0.326307978864259 1.01995308687505 0.434782608695652 19.4 19 4 abnormal sacral vertebrae morphology 0.117536461934624 0.326307978864259 1.01995308687505 0.434782608695652 19.4 19 4 abnormal Wolffian duct morphology 0.117536461934624 0.326307978864259 1.01995308687505 0.434782608695652 19.4 19 4 abnormal lens development 0.117536461934624 0.326307978864259 1.01995308687505 0.434782608695652 19.4 19 4 abnormal palatal shelf fusion at midline 0.117536461934624 0.326307978864259 1.01995308687505 0.434782608695652 19.4 19 4 increased leukocyte cell number 0.000362121294420605 0.00466723689052464 1.01924967095306 0.43448275862069 19.4 19 4 deafness 0.00289771612052459 0.0248554098269135 1.01892283123174 0.434343434343434 19.4 19 4 abnormal coat/ hair morphology 0.0253753445473408 0.12316504975042 1.01802864708849 0.433962264150943 19.4 19 4 abnormal lipid level 0.00624225569947425 0.0443013154135298 1.01749536859342 0.433734939759036 19.4 19 4 gastrointestinal hemorrhage 0.0822289287060544 0.264575882010777 1.01655324325213 0.433333333333333 19.4 19 4 abnormal pain threshold 0.0822289287060544 0.264575882010777 1.01655324325213 0.433333333333333 19.4 19 4 abnormal spleen marginal zone morphology 0.0822289287060544 0.264575882010777 1.01655324325213 0.433333333333333 19.4 19 4 abnormal fat pad morphology 0.0822289287060544 0.264575882010777 1.01655324325213 0.433333333333333 19.4 19 4 decreased white adipose tissue amount 0.0136459108981537 0.0764509084665705 1.01538613275471 0.432835820895522 19.4 19 4 abnormal long bone metaphysis morphology 0.0584862152415639 0.21601256186101 1.01443982694599 0.432432432432432 19.4 19 4 abnormal branching of the mammary ductal tree 0.0584862152415639 0.21601256186101 1.01443982694599 0.432432432432432 19.4 19 4 increased insulin secretion 0.0584862152415639 0.21601256186101 1.01443982694599 0.432432432432432 19.4 19 4 increased trabecular bone volume 0.0584862152415639 0.21601256186101 1.01443982694599 0.432432432432432 19.4 19 4 abnormal skeleton development 0.0074462379253707 0.0512379442305937 1.01365708016594 0.432098765432099 19.4 19 4 dermatitis 0.0222633870045042 0.113483965519886 1.01116038785026 0.431034482758621 19.4 19 4 glomerulosclerosis 0.0222633870045042 0.113483965519886 1.01116038785026 0.431034482758621 19.4 19 4 decreased monocyte cell number 0.0163265610588593 0.0887700997462566 1.01053813530389 0.430769230769231 19.4 19 4 abnormal inflammatory response 0.0120206036445751 0.0691358417708223 1.0100368763082 0.430555555555556 19.4 19 4 abnormal heart left ventricle morphology 0.0120206036445751 0.0691358417708223 1.0100368763082 0.430555555555556 19.4 19 4 abnormal eye electrophysiology 0.00151055577628321 0.0147642730589567 1.00815197677897 0.429752066115702 19.4 19 4 improved glucose tolerance 7.68262464415175e-05 0.00128690429645303 1.00538232849112 0.428571428571429 19.4 19 4 abnormal lung morphology 0.00179045870188871 0.016680771614038 1.00538232849112 0.428571428571429 19.4 19 4 thick epidermis 0.014351004248009 0.0798615728566497 1.00538232849112 0.428571428571429 19.4 19 4 abnormal action potential 0.014351004248009 0.0798615728566497 1.00538232849112 0.428571428571429 19.4 19 4 skin edema 0.0507518536553606 0.196337847539206 1.00538232849112 0.428571428571429 19.4 19 4 abnormal reproductive system morphology 0.0507518536553606 0.196337847539206 1.00538232849112 0.428571428571429 19.4 19 4 abnormal liver development 0.0708934459278752 0.245609257305835 1.00538232849112 0.428571428571429 19.4 19 4 abnormal intestinal goblet cell morphology 0.0708934459278752 0.245609257305835 1.00538232849112 0.428571428571429 19.4 19 4 holoprosencephaly 0.0708934459278752 0.245609257305835 1.00538232849112 0.428571428571429 19.4 19 4 decreased circulating thyroxine level 0.0708934459278752 0.245609257305835 1.00538232849112 0.428571428571429 19.4 19 4 small superior cervical ganglion 0.100340036423503 0.287387266094951 1.00538232849112 0.428571428571429 19.4 19 4 increased triglyceride level 0.100340036423503 0.287387266094951 1.00538232849112 0.428571428571429 19.4 19 4 abnormal anxiety-related response 0.144888997787484 0.38321252737519 1.00538232849112 0.428571428571429 19.4 19 4 abnormal hematopoietic system physiology 0.144888997787484 0.38321252737519 1.00538232849112 0.428571428571429 19.4 19 4 hypoalgesia 0.144888997787484 0.38321252737519 1.00538232849112 0.428571428571429 19.4 19 4 liver degeneration 0.144888997787484 0.38321252737519 1.00538232849112 0.428571428571429 19.4 19 4 abnormal stapes morphology 0.144888997787484 0.38321252737519 1.00538232849112 0.428571428571429 19.4 19 4 complete atrioventricular septal defect 0.144888997787484 0.38321252737519 1.00538232849112 0.428571428571429 19.4 19 4 increased bone ossification 0.144888997787484 0.38321252737519 1.00538232849112 0.428571428571429 19.4 19 4 decreased vocalization 0.144888997787484 0.38321252737519 1.00538232849112 0.428571428571429 19.4 19 4 abnormal vasoconstriction 0.216609149015565 0.475355322608044 1.00538232849112 0.428571428571429 19.4 19 4 abnormal zigzag hair morphology 0.216609149015565 0.475355322608044 1.00538232849112 0.428571428571429 19.4 19 4 abnormal pinna reflex 0.216609149015565 0.475355322608044 1.00538232849112 0.428571428571429 19.4 19 4 abnormal olfactory system physiology 0.216609149015565 0.475355322608044 1.00538232849112 0.428571428571429 19.4 19 4 abnormal endplate potential 0.216609149015565 0.475355322608044 1.00538232849112 0.428571428571429 19.4 19 4 abnormal kidney medulla morphology 0.216609149015565 0.475355322608044 1.00538232849112 0.428571428571429 19.4 19 4 abnormal decidualization 0.216609149015565 0.475355322608044 1.00538232849112 0.428571428571429 19.4 19 4 enlarged stomach 0.216609149015565 0.475355322608044 1.00538232849112 0.428571428571429 19.4 19 4 abnormal pancreas development 0.216609149015565 0.475355322608044 1.00538232849112 0.428571428571429 19.4 19 4 decreased response to antigen 0.216609149015565 0.475355322608044 1.00538232849112 0.428571428571429 19.4 19 4 pericardial edema 0.0171265821668651 0.0921132392217878 1.00045398374361 0.426470588235294 19.4 19 4 decreased circulating alanine transaminase level 0.0171265821668651 0.0921132392217878 1.00045398374361 0.426470588235294 19.4 19 4 increased double-negative T cell number 0.0233480527056315 0.11840628156016 0.9998884359857 0.426229508196721 19.4 19 4 abnormal chondrocyte morphology 0.0319827461034756 0.136227878308897 0.999176264734998 0.425925925925926 19.4 19 4 abnormal long bone epiphyseal plate proliferative zone 0.0319827461034756 0.136227878308897 0.999176264734998 0.425925925925926 19.4 19 4 hepatic necrosis 0.0440766516778637 0.177555742588965 0.998251957367066 0.425531914893617 19.4 19 4 abnormal innervation 0.0440766516778637 0.177555742588965 0.998251957367066 0.425531914893617 19.4 19 4 increased total body fat amount 0.00124246368417825 0.0128495267977083 0.997879475293421 0.425373134328358 19.4 19 4 short limbs 0.00820104864377183 0.0533336169970783 0.997678249345591 0.425287356321839 19.4 19 4 decreased circulating phosphate level 0.0612235005557636 0.222488615971456 0.997004142420357 0.425 19.4 19 4 abnormal pancreatic beta cell morphology 0.0612235005557636 0.222488615971456 0.997004142420357 0.425 19.4 19 4 cardiovascular system phenotype 0.0859529799420902 0.264575882010777 0.99522695143565 0.424242424242424 19.4 19 4 decreased sensitivity to xenobiotic induced morbidity/mortality 0.0859529799420902 0.264575882010777 0.99522695143565 0.424242424242424 19.4 19 4 decreased bone resorption 0.122538328915547 0.338620303709407 0.992492811459179 0.423076923076923 19.4 19 4 abnormal metabolism 0.0529589729619122 0.204241000376367 0.990487775476433 0.422222222222222 19.4 19 4 decreased circulating HDL cholesterol level 0.00204655065036592 0.018681815569854 0.989673229608443 0.421875 19.4 19 4 abnormal lens morphology 0.00204655065036592 0.018681815569854 0.989673229608443 0.421875 19.4 19 4 irregular coat pigmentation 0.178975868645254 0.440140853440504 0.98774404202636 0.421052631578947 19.4 19 4 enlarged adrenal glands 0.178975868645254 0.440140853440504 0.98774404202636 0.421052631578947 19.4 19 4 thin dermal layer 0.178975868645254 0.440140853440504 0.98774404202636 0.421052631578947 19.4 19 4 abnormal stationary movement 0.178975868645254 0.440140853440504 0.98774404202636 0.421052631578947 19.4 19 4 stereotypic behavior 0.178975868645254 0.440140853440504 0.98774404202636 0.421052631578947 19.4 19 4 abnormal nasal septum morphology 0.178975868645254 0.440140853440504 0.98774404202636 0.421052631578947 19.4 19 4 abnormal response to novelty 0.178975868645254 0.440140853440504 0.98774404202636 0.421052631578947 19.4 19 4 absent amnion 0.178975868645254 0.440140853440504 0.98774404202636 0.421052631578947 19.4 19 4 eyelids fail to open 0.178975868645254 0.440140853440504 0.98774404202636 0.421052631578947 19.4 19 4 abnormal behavioral response to xenobiotic 0.178975868645254 0.440140853440504 0.98774404202636 0.421052631578947 19.4 19 4 decreased liver glycogen level 0.178975868645254 0.440140853440504 0.98774404202636 0.421052631578947 19.4 19 4 thin interventricular septum 0.178975868645254 0.440140853440504 0.98774404202636 0.421052631578947 19.4 19 4 increased lymphocyte cell number 0.0212767603896201 0.108789191098006 0.985954650645877 0.420289855072464 19.4 19 4 lethargy 0.00890363318474174 0.057452107774436 0.983761203147221 0.419354838709677 19.4 19 4 absent mature ovarian follicles 0.10423156606828 0.29665448580646 0.983761203147221 0.419354838709677 19.4 19 4 abnormal T cell proliferation 0.10423156606828 0.29665448580646 0.983761203147221 0.419354838709677 19.4 19 4 decreased neutrophil cell number 0.00381244560337666 0.0304934354932458 0.98246763154545 0.418803418803419 19.4 19 4 increased circulating glucose level 0.00165658155779195 0.0155499872641792 0.981614424744281 0.418439716312057 19.4 19 4 abnormal response to infection 0.0162590092180082 0.0887700997462566 0.979929611314126 0.417721518987342 19.4 19 4 abnormal hair shaft morphology 0.0549130103372469 0.211285557948804 0.977455041588585 0.416666666666667 19.4 19 4 decreased body height 0.149768908780029 0.387871067767123 0.977455041588585 0.416666666666667 19.4 19 4 curly vibrissae 0.149768908780029 0.387871067767123 0.977455041588585 0.416666666666667 19.4 19 4 abnormal cardiac muscle contractility 0.149768908780029 0.387871067767123 0.977455041588585 0.416666666666667 19.4 19 4 abnormal inner cell mass apoptosis 0.149768908780029 0.387871067767123 0.977455041588585 0.416666666666667 19.4 19 4 abnormal adipose tissue distribution 0.273347943614133 0.515567933036579 0.977455041588585 0.416666666666667 19.4 19 4 amyloidosis 0.273347943614133 0.515567933036579 0.977455041588585 0.416666666666667 19.4 19 4 abnormal glossopharyngeal nerve morphology 0.273347943614133 0.515567933036579 0.977455041588585 0.416666666666667 19.4 19 4 absent optic nerve 0.273347943614133 0.515567933036579 0.977455041588585 0.416666666666667 19.4 19 4 altered tumor susceptibility 0.273347943614133 0.515567933036579 0.977455041588585 0.416666666666667 19.4 19 4 abnormal tracheal ciliated epithelium morphology 0.273347943614133 0.515567933036579 0.977455041588585 0.416666666666667 19.4 19 4 increased circulating parathyroid hormone level 0.273347943614133 0.515567933036579 0.977455041588585 0.416666666666667 19.4 19 4 small thyroid gland 0.273347943614133 0.515567933036579 0.977455041588585 0.416666666666667 19.4 19 4 absent tail 0.273347943614133 0.515567933036579 0.977455041588585 0.416666666666667 19.4 19 4 abnormal vascular endothelial cell development 0.273347943614133 0.515567933036579 0.977455041588585 0.416666666666667 19.4 19 4 abnormal cochlear outer hair cell physiology 0.273347943614133 0.515567933036579 0.977455041588585 0.416666666666667 19.4 19 4 abnormal palatine bone morphology 0.273347943614133 0.515567933036579 0.977455041588585 0.416666666666667 19.4 19 4 decreased keratinocyte proliferation 0.273347943614133 0.515567933036579 0.977455041588585 0.416666666666667 19.4 19 4 hydrometra 0.273347943614133 0.515567933036579 0.977455041588585 0.416666666666667 19.4 19 4 abnormal behavioral response to addictive substance 0.273347943614133 0.515567933036579 0.977455041588585 0.416666666666667 19.4 19 4 abnormal aorta elastic tissue morphology 0.273347943614133 0.515567933036579 0.977455041588585 0.416666666666667 19.4 19 4 increased skeletal muscle glycogen level 0.273347943614133 0.515567933036579 0.977455041588585 0.416666666666667 19.4 19 4 increased type II pneumocyte number 0.273347943614133 0.515567933036579 0.977455041588585 0.416666666666667 19.4 19 4 decreased compensatory feeding amount 0.273347943614133 0.515567933036579 0.977455041588585 0.416666666666667 19.4 19 4 scaly skin 0.0763715047817563 0.260869072385737 0.972686968214982 0.414634146341463 19.4 19 4 decreased IgG level 0.00623814071938977 0.0443013154135298 0.972171500823242 0.414414414414414 19.4 19 4 abnormal middle ear morphology 0.126413231505814 0.343476694014977 0.97071397233625 0.413793103448276 19.4 19 4 increased circulating aspartate transaminase level 0.0357063830464756 0.150669428037503 0.968145945954408 0.412698412698413 19.4 19 4 abnormal social investigation 0.0198932670319817 0.104397683000115 0.967680491172699 0.4125 19.4 19 4 decreased IgM level 0.0112577976101764 0.0652008650880416 0.967378185489734 0.412371134020619 19.4 19 4 decreased T cell proliferation 0.00215385172900944 0.0195894192903509 0.966887960057898 0.412162162162162 19.4 19 4 circling 0.0173640120629179 0.0930883189795438 0.965955570511073 0.411764705882353 19.4 19 4 increased kidney weight 0.0566397126138128 0.213492862487892 0.965955570511073 0.411764705882353 19.4 19 4 thin skin 0.107374495482142 0.305250351442089 0.965955570511073 0.411764705882353 19.4 19 4 increased susceptibility to weight gain 0.107374495482142 0.305250351442089 0.965955570511073 0.411764705882353 19.4 19 4 abnormal ectoplacental cone morphology 0.221588105913073 0.484784884308505 0.965955570511073 0.411764705882353 19.4 19 4 abnormal melanosome morphology 0.221588105913073 0.484784884308505 0.965955570511073 0.411764705882353 19.4 19 4 decreased growth hormone level 0.221588105913073 0.484784884308505 0.965955570511073 0.411764705882353 19.4 19 4 small lens 0.091645804726081 0.268198752066031 0.962417271717992 0.41025641025641 19.4 19 4 decreased B-1 B cell number 0.091645804726081 0.268198752066031 0.962417271717992 0.41025641025641 19.4 19 4 decreased trabecular bone volume 0.091645804726081 0.268198752066031 0.962417271717992 0.41025641025641 19.4 19 4 abnormal NK cell physiology 0.0423700972781215 0.172215060423737 0.961431188447789 0.409836065573771 19.4 19 4 abnormal circadian rhythm 0.078523045380327 0.264575882010777 0.95968313174152 0.409090909090909 19.4 19 4 abnormal enterocyte morphology 0.183195805799532 0.44918636463907 0.95968313174152 0.409090909090909 19.4 19 4 intestinal inflammation 0.183195805799532 0.44918636463907 0.95968313174152 0.409090909090909 19.4 19 4 testis hypoplasia 0.183195805799532 0.44918636463907 0.95968313174152 0.409090909090909 19.4 19 4 abnormal channel response 0.183195805799532 0.44918636463907 0.95968313174152 0.409090909090909 19.4 19 4 abnormal retinal outer plexiform layer morphology 0.183195805799532 0.44918636463907 0.95968313174152 0.409090909090909 19.4 19 4 decreased susceptibility to viral infection induced morbidity/mortality 0.183195805799532 0.44918636463907 0.95968313174152 0.409090909090909 19.4 19 4 abnormal locomotor activation 0.0183435640839597 0.0977079564429333 0.953824260363367 0.406593406593407 19.4 19 4 abnormal tooth morphology 0.043469955573765 0.175538172872955 0.953018665548871 0.40625 19.4 19 4 abnormal crypts of Lieberkuhn morphology 0.129405273956772 0.347244464905577 0.953018665548871 0.40625 19.4 19 4 abnormal lymphatic vessel morphology 0.129405273956772 0.347244464905577 0.953018665548871 0.40625 19.4 19 4 increased dopamine level 0.129405273956772 0.347244464905577 0.953018665548871 0.40625 19.4 19 4 abnormal diaphragm morphology 0.129405273956772 0.347244464905577 0.953018665548871 0.40625 19.4 19 4 abnormal T cell differentiation 0.0139844725264216 0.0780838954196944 0.952292832597196 0.405940594059406 19.4 19 4 abnormal epidermal layer morphology 0.0376792603258233 0.156252660961671 0.951956214416709 0.405797101449275 19.4 19 4 increased erythroid progenitor cell number 0.109904341024396 0.311907642097187 0.951037337761867 0.405405405405405 19.4 19 4 decreased width of hypertrophic chondrocyte zone 0.109904341024396 0.311907642097187 0.951037337761867 0.405405405405405 19.4 19 4 abnormal calcium ion homeostasis 0.109904341024396 0.311907642097187 0.951037337761867 0.405405405405405 19.4 19 4 hydronephrosis 0.0247384292967618 0.122446066452502 0.949527754686054 0.404761904761905 19.4 19 4 increased food intake 0.0247384292967618 0.122446066452502 0.949527754686054 0.404761904761905 19.4 19 4 increased systemic arterial blood pressure 0.080351683526078 0.264575882010777 0.948339359498713 0.404255319148936 19.4 19 4 decreased bone trabecula number 0.080351683526078 0.264575882010777 0.948339359498713 0.404255319148936 19.4 19 4 increased susceptibility to injury 0.0690538314397159 0.241670566318497 0.947379501847398 0.403846153846154 19.4 19 4 decreased susceptibility to induced arthritis 0.0595008371927679 0.219109300543316 0.946588040275262 0.403508771929825 19.4 19 4 abnormal dendritic cell physiology 0.0146346099823257 0.0812580185960606 0.942741684971421 0.401869158878505 19.4 19 4 dehydration 0.0453484565742396 0.182531206680293 0.938356839925042 0.4 19.4 19 4 salivary gland inflammation 0.15586943337232 0.403040764567199 0.938356839925042 0.4 19.4 19 4 abnormal estrous cycle 0.15586943337232 0.403040764567199 0.938356839925042 0.4 19.4 19 4 abnormal primitive streak morphology 0.185931622359362 0.454773756754095 0.938356839925042 0.4 19.4 19 4 diaphragmatic hernia 0.185931622359362 0.454773756754095 0.938356839925042 0.4 19.4 19 4 abnormal preimplantation embryo development 0.185931622359362 0.454773756754095 0.938356839925042 0.4 19.4 19 4 increased liver glycogen level 0.185931622359362 0.454773756754095 0.938356839925042 0.4 19.4 19 4 interdigital webbing 0.275034557755356 0.515567933036579 0.938356839925042 0.4 19.4 19 4 joint inflammation 0.275034557755356 0.515567933036579 0.938356839925042 0.4 19.4 19 4 greasy coat 0.275034557755356 0.515567933036579 0.938356839925042 0.4 19.4 19 4 abnormal ear development 0.275034557755356 0.515567933036579 0.938356839925042 0.4 19.4 19 4 abnormal neurotransmitter secretion 0.275034557755356 0.515567933036579 0.938356839925042 0.4 19.4 19 4 abnormal energy homeostasis 0.275034557755356 0.515567933036579 0.938356839925042 0.4 19.4 19 4 absent chorion 0.275034557755356 0.515567933036579 0.938356839925042 0.4 19.4 19 4 perinatal lethality 0.111927340839626 0.316385523112011 0.938356839925042 0.4 19.4 19 4 abnormal hair texture 0.224246106597419 0.488304326823191 0.938356839925042 0.4 19.4 19 4 abnormal male reproductive system physiology 0.224246106597419 0.488304326823191 0.938356839925042 0.4 19.4 19 4 abnormal optic stalk morphology 0.224246106597419 0.488304326823191 0.938356839925042 0.4 19.4 19 4 kidney atrophy 0.224246106597419 0.488304326823191 0.938356839925042 0.4 19.4 19 4 enhanced behavioral response to xenobiotic 0.224246106597419 0.488304326823191 0.938356839925042 0.4 19.4 19 4 abnormal circulating cytokine level 0.224246106597419 0.488304326823191 0.938356839925042 0.4 19.4 19 4 nuclear cataracts 0.224246106597419 0.488304326823191 0.938356839925042 0.4 19.4 19 4 increased liver weight 0.0301936365439407 0.132338206806541 0.933025266970922 0.397727272727273 19.4 19 4 skin lesions 0.0616983080362469 0.224050425168123 0.9309095634177 0.396825396825397 19.4 19 4 increased susceptibility to pharmacologically induced seizures 0.0267125806393373 0.12316504975042 0.928582289509156 0.395833333333333 19.4 19 4 abnormal osteoclast morphology 0.0970184004428985 0.279466751594501 0.928582289509156 0.395833333333333 19.4 19 4 increased grooming behavior 0.133419494128717 0.357630378928001 0.926010039399712 0.394736842105263 19.4 19 4 abnormal reproductive system physiology 0.133419494128717 0.357630378928001 0.926010039399712 0.394736842105263 19.4 19 4 impaired swimming 0.0625878721769248 0.227114999329104 0.92413931204739 0.393939393939394 19.4 19 4 head tossing 0.157649265066315 0.40374165981809 0.92413931204739 0.393939393939394 19.4 19 4 abnormal maternal nurturing 0.072547017863823 0.249613829852836 0.922973940909877 0.39344262295082 19.4 19 4 increased osteoclast cell number 0.072547017863823 0.249613829852836 0.922973940909877 0.39344262295082 19.4 19 4 increased body weight 0.00161560863488961 0.0154149056795613 0.921600467783523 0.392857142857143 19.4 19 4 failure of blastocyst to hatch from the zona pellucida 0.187600800691867 0.456258263833589 0.921600467783523 0.392857142857143 19.4 19 4 enhanced coordination 0.187600800691867 0.456258263833589 0.921600467783523 0.392857142857143 19.4 19 4 blistering 0.225405383998403 0.488304326823191 0.917957778187541 0.391304347826087 19.4 19 4 abnormal cardiovascular development 0.225405383998403 0.488304326823191 0.917957778187541 0.391304347826087 19.4 19 4 increased susceptibility to age related obesity 0.225405383998403 0.488304326823191 0.917957778187541 0.391304347826087 19.4 19 4 abnormal B cell morphology 0.225405383998403 0.488304326823191 0.917957778187541 0.391304347826087 19.4 19 4 abnormal chondrocyte physiology 0.225405383998403 0.488304326823191 0.917957778187541 0.391304347826087 19.4 19 4 abnormal basicranium morphology 0.225405383998403 0.488304326823191 0.917957778187541 0.391304347826087 19.4 19 4 hyperkeratosis 0.0633557475677279 0.229070424860614 0.917957778187541 0.391304347826087 19.4 19 4 abnormal retinal pigmentation 0.0417058492431097 0.169931695318977 0.91678541831757 0.390804597701149 19.4 19 4 polyphagia 0.0991345918907436 0.28426201421121 0.912291372149346 0.388888888888889 19.4 19 4 abnormal epidermis stratum granulosum morphology 0.158827220823292 0.40374165981809 0.912291372149346 0.388888888888889 19.4 19 4 impaired wound healing 0.158827220823292 0.40374165981809 0.912291372149346 0.388888888888889 19.4 19 4 short radius 0.158827220823292 0.40374165981809 0.912291372149346 0.388888888888889 19.4 19 4 blepharoptosis 0.274653186020208 0.515567933036579 0.912291372149346 0.388888888888889 19.4 19 4 abnormal iron level 0.274653186020208 0.515567933036579 0.912291372149346 0.388888888888889 19.4 19 4 absent allantois 0.274653186020208 0.515567933036579 0.912291372149346 0.388888888888889 19.4 19 4 increased circulating glycerol level 0.274653186020208 0.515567933036579 0.912291372149346 0.388888888888889 19.4 19 4 abnormal macrophage chemotaxis 0.274653186020208 0.515567933036579 0.912291372149346 0.388888888888889 19.4 19 4 abnormal metanephric mesenchyme morphology 0.274653186020208 0.515567933036579 0.912291372149346 0.388888888888889 19.4 19 4 impaired leukocyte tethering or rolling 0.274653186020208 0.515567933036579 0.912291372149346 0.388888888888889 19.4 19 4 increased sarcoma incidence 0.115718814993659 0.324304300326911 0.909631630539581 0.387755102040816 19.4 19 4 abnormal immune system physiology 0.0218687796479574 0.111701415552965 0.908087264443589 0.387096774193548 19.4 19 4 decreased neuronal precursor cell number 0.188482823248556 0.456258263833589 0.908087264443589 0.387096774193548 19.4 19 4 abnormal trabecular bone morphology 0.025022313004475 0.122537020531116 0.906815433541007 0.38655462184874 19.4 19 4 short femur 0.0489542794611052 0.189678769718846 0.906367402200325 0.386363636363636 19.4 19 4 decreased macrophage cell number 0.135567817397445 0.362802523696767 0.906367402200325 0.386363636363636 19.4 19 4 decreased IgA level 0.116409112614691 0.324809498181764 0.902266192235617 0.384615384615385 19.4 19 4 abnormal hair growth 0.116409112614691 0.324809498181764 0.902266192235617 0.384615384615385 19.4 19 4 increased percent body fat/body weight 0.116409112614691 0.324809498181764 0.902266192235617 0.384615384615385 19.4 19 4 increased vascular permeability 0.159528050005365 0.40374165981809 0.902266192235617 0.384615384615385 19.4 19 4 abnormal leukocyte adhesion 0.159528050005365 0.40374165981809 0.902266192235617 0.384615384615385 19.4 19 4 abnormal circulating hormone level 0.159528050005365 0.40374165981809 0.902266192235617 0.384615384615385 19.4 19 4 abnormal leukocyte cell number 0.225552430761747 0.488304326823191 0.902266192235617 0.384615384615385 19.4 19 4 abnormal stomach morphology 0.225552430761747 0.488304326823191 0.902266192235617 0.384615384615385 19.4 19 4 abnormal ureter morphology 0.225552430761747 0.488304326823191 0.902266192235617 0.384615384615385 19.4 19 4 increased susceptibility to otitis media 0.225552430761747 0.488304326823191 0.902266192235617 0.384615384615385 19.4 19 4 abnormal ocular fundus morphology 0.225552430761747 0.488304326823191 0.902266192235617 0.384615384615385 19.4 19 4 short hair 0.342288266648546 0.5568980672227 0.902266192235617 0.384615384615385 19.4 19 4 pup cannibalization 0.342288266648546 0.5568980672227 0.902266192235617 0.384615384615385 19.4 19 4 lymphoid hypoplasia 0.342288266648546 0.5568980672227 0.902266192235617 0.384615384615385 19.4 19 4 abnormal bile duct development 0.342288266648546 0.5568980672227 0.902266192235617 0.384615384615385 19.4 19 4 abnormal telomere length 0.342288266648546 0.5568980672227 0.902266192235617 0.384615384615385 19.4 19 4 abnormal vestibulocochlear ganglion morphology 0.342288266648546 0.5568980672227 0.902266192235617 0.384615384615385 19.4 19 4 vestibular hair cell degeneration 0.342288266648546 0.5568980672227 0.902266192235617 0.384615384615385 19.4 19 4 increased circulating thyroid-stimulating hormone level 0.342288266648546 0.5568980672227 0.902266192235617 0.384615384615385 19.4 19 4 increased circulating ammonia level 0.342288266648546 0.5568980672227 0.902266192235617 0.384615384615385 19.4 19 4 increased renin activity 0.342288266648546 0.5568980672227 0.902266192235617 0.384615384615385 19.4 19 4 abnormal hair follicle inner root sheath morphology 0.342288266648546 0.5568980672227 0.902266192235617 0.384615384615385 19.4 19 4 decreased cardiac stroke volume 0.342288266648546 0.5568980672227 0.902266192235617 0.384615384615385 19.4 19 4 increased width of hypertrophic chondrocyte zone 0.188771741475564 0.456258263833589 0.896958744045996 0.382352941176471 19.4 19 4 abnormal humoral immune response 0.0436935074843732 0.176297810003858 0.893673180880992 0.380952380952381 19.4 19 4 abnormal associative learning 0.273081250480456 0.515567933036579 0.893673180880992 0.380952380952381 19.4 19 4 abnormal CD4-positive, alpha-beta T cell physiology 0.0872779158587121 0.264575882010777 0.892099812604793 0.380281690140845 19.4 19 4 abnormal hindlimb morphology 0.136447003575983 0.364567047685561 0.89143899792879 0.38 19.4 19 4 abnormal digestive system physiology 0.136447003575983 0.364567047685561 0.89143899792879 0.38 19.4 19 4 testicular atrophy 0.136447003575983 0.364567047685561 0.89143899792879 0.38 19.4 19 4 abnormal microglial cell morphology 0.224993204083344 0.488304326823191 0.889821141308229 0.379310344827586 19.4 19 4 abnormal circulating glucose level 0.224993204083344 0.488304326823191 0.889821141308229 0.379310344827586 19.4 19 4 focal hair loss 0.224993204083344 0.488304326823191 0.889821141308229 0.379310344827586 19.4 19 4 stomach inflammation 0.224993204083344 0.488304326823191 0.889821141308229 0.379310344827586 19.4 19 4 increased brown adipose tissue amount 0.188606365048707 0.456258263833589 0.887634848577742 0.378378378378378 19.4 19 4 decreased circulating chloride level 0.188606365048707 0.456258263833589 0.887634848577742 0.378378378378378 19.4 19 4 abnormal chromosome morphology 0.188606365048707 0.456258263833589 0.887634848577742 0.378378378378378 19.4 19 4 abnormal respiratory electron transport chain 0.188606365048707 0.456258263833589 0.887634848577742 0.378378378378378 19.4 19 4 abnormal response/metabolism to endogenous compounds 0.0759904906235966 0.260187674365033 0.886861647490131 0.378048780487805 19.4 19 4 abnormal autopod morphology 0.159854780619432 0.40374165981809 0.886225904373651 0.377777777777778 19.4 19 4 abnormal pancreatic islet morphology 0.136535327415316 0.36460722162705 0.885242301816077 0.377358490566038 19.4 19 4 abnormal coat appearance 0.101207544558896 0.289538547544859 0.883959341958373 0.376811594202899 19.4 19 4 abnormal food intake 0.101207544558896 0.289538547544859 0.883959341958373 0.376811594202899 19.4 19 4 abnormal cytokine secretion 0.0231139942671958 0.117338899468673 0.883517803825527 0.376623376623377 19.4 19 4 obese 0.0876438885016075 0.264575882010777 0.883517803825527 0.376623376623377 19.4 19 4 abnormal intestinal epithelium morphology 0.159610559648666 0.40374165981809 0.879709537429727 0.375 19.4 19 4 abnormal lymph node morphology 0.159610559648666 0.40374165981809 0.879709537429727 0.375 19.4 19 4 increased fatty acid level 0.223929352823626 0.488304326823191 0.879709537429727 0.375 19.4 19 4 abnormal foregut morphology 0.270787269129427 0.515567933036579 0.879709537429727 0.375 19.4 19 4 abnormal vasodilation 0.270787269129427 0.515567933036579 0.879709537429727 0.375 19.4 19 4 apnea 0.270787269129427 0.515567933036579 0.879709537429727 0.375 19.4 19 4 abnormal sensory capabilities/reflexes/nociception 0.270787269129427 0.515567933036579 0.879709537429727 0.375 19.4 19 4 decreased ovulation rate 0.270787269129427 0.515567933036579 0.879709537429727 0.375 19.4 19 4 abnormal hair follicle orientation 0.336483841936427 0.5568980672227 0.879709537429727 0.375 19.4 19 4 delayed hair appearance 0.336483841936427 0.5568980672227 0.879709537429727 0.375 19.4 19 4 abnormal extraembryonic endoderm formation 0.336483841936427 0.5568980672227 0.879709537429727 0.375 19.4 19 4 abnormal olfaction 0.336483841936427 0.5568980672227 0.879709537429727 0.375 19.4 19 4 large intestinal inflammation 0.336483841936427 0.5568980672227 0.879709537429727 0.375 19.4 19 4 decreased aggression towards mice 0.336483841936427 0.5568980672227 0.879709537429727 0.375 19.4 19 4 abnormal molar crown morphology 0.336483841936427 0.5568980672227 0.879709537429727 0.375 19.4 19 4 abnormal amnion morphology 0.336483841936427 0.5568980672227 0.879709537429727 0.375 19.4 19 4 abnormal level of surface class II molecules 0.336483841936427 0.5568980672227 0.879709537429727 0.375 19.4 19 4 impaired behavioral response to addictive substance 0.336483841936427 0.5568980672227 0.879709537429727 0.375 19.4 19 4 abnormal male reproductive system morphology 0.187294274679479 0.456258263833589 0.872890083651202 0.372093023255814 19.4 19 4 abnormal inner ear morphology 0.186281834238155 0.455406449795982 0.866960123843789 0.369565217391304 19.4 19 4 abnormal nail morphology 0.330464954488931 0.5568980672227 0.864276036773065 0.368421052631579 19.4 19 4 decreased grooming behavior 0.330464954488931 0.5568980672227 0.864276036773065 0.368421052631579 19.4 19 4 altered susceptibility to infection 0.330464954488931 0.5568980672227 0.864276036773065 0.368421052631579 19.4 19 4 osteoarthritis 0.330464954488931 0.5568980672227 0.864276036773065 0.368421052631579 19.4 19 4 decreased fertilization frequency 0.330464954488931 0.5568980672227 0.864276036773065 0.368421052631579 19.4 19 4 abnormal inhibitory postsynaptic currents 0.134689060305863 0.360644819710262 0.862460330813458 0.367647058823529 19.4 19 4 decreased susceptibility to injury 0.134689060305863 0.360644819710262 0.862460330813458 0.367647058823529 19.4 19 4 abnormal long bone epiphyseal plate morphology 0.156887804560028 0.40374165981809 0.860160436597955 0.366666666666667 19.4 19 4 arrested T cell differentiation 0.265012229231832 0.515567933036579 0.860160436597955 0.366666666666667 19.4 19 4 arrested B cell differentiation 0.218899282959508 0.479534976980868 0.858253207248514 0.365853658536585 19.4 19 4 increased tumor growth/size 0.218899282959508 0.479534976980868 0.858253207248514 0.365853658536585 19.4 19 4 decreased body temperature 0.183772269504688 0.450377852603854 0.857152882623836 0.365384615384615 19.4 19 4 hypertension 0.216852250269214 0.475469345566037 0.853051672659129 0.363636363636364 19.4 19 4 decreased sensitivity to induced morbidity/mortality 0.216852250269214 0.475469345566037 0.853051672659129 0.363636363636364 19.4 19 4 intestinal ulcer 0.324444361726697 0.556589896410454 0.853051672659129 0.363636363636364 19.4 19 4 increased body size 0.324444361726697 0.556589896410454 0.853051672659129 0.363636363636364 19.4 19 4 abnormal female reproductive system physiology 0.324444361726697 0.556589896410454 0.853051672659129 0.363636363636364 19.4 19 4 abnormal mesenteric lymph node morphology 0.324444361726697 0.556589896410454 0.853051672659129 0.363636363636364 19.4 19 4 impaired humoral immune response 0.324444361726697 0.556589896410454 0.853051672659129 0.363636363636364 19.4 19 4 absent vibrissae 0.261803688684946 0.515567933036579 0.853051672659129 0.363636363636364 19.4 19 4 decreased systemic arterial blood pressure 0.261803688684946 0.515567933036579 0.853051672659129 0.363636363636364 19.4 19 4 increased bone mineral density 0.0847272726368916 0.264575882010777 0.851164390197494 0.36283185840708 19.4 19 4 increased susceptibility to bacterial infection induced morbidity/mortality 0.152525017800646 0.394803310904379 0.847127702710107 0.361111111111111 19.4 19 4 renal hypoplasia 0.258487070666356 0.515567933036579 0.847127702710107 0.361111111111111 19.4 19 4 reddish skin 0.312731900045949 0.537795092543587 0.83781860707593 0.357142857142857 19.4 19 4 increased circulating luteinizing hormone level 0.312731900045949 0.537795092543587 0.83781860707593 0.357142857142857 19.4 19 4 abnormal spleen germinal center morphology 0.312731900045949 0.537795092543587 0.83781860707593 0.357142857142857 19.4 19 4 abnormal retinal inner nuclear layer morphology 0.312731900045949 0.537795092543587 0.83781860707593 0.357142857142857 19.4 19 4 abnormal mitotic spindle morphology 0.312731900045949 0.537795092543587 0.83781860707593 0.357142857142857 19.4 19 4 absent atrioventricular cushions 0.41210999866687 0.647787438662773 0.83781860707593 0.357142857142857 19.4 19 4 increased aggression towards males 0.41210999866687 0.647787438662773 0.83781860707593 0.357142857142857 19.4 19 4 abnormal adrenal gland secretion 0.41210999866687 0.647787438662773 0.83781860707593 0.357142857142857 19.4 19 4 abnormal antigen presentation 0.41210999866687 0.647787438662773 0.83781860707593 0.357142857142857 19.4 19 4 decreased coping response 0.41210999866687 0.647787438662773 0.83781860707593 0.357142857142857 19.4 19 4 abnormal imprinting 0.41210999866687 0.647787438662773 0.83781860707593 0.357142857142857 19.4 19 4 abnormal hair cuticle 0.41210999866687 0.647787438662773 0.83781860707593 0.357142857142857 19.4 19 4 abnormal positive T cell selection 0.41210999866687 0.647787438662773 0.83781860707593 0.357142857142857 19.4 19 4 premature hair loss 0.41210999866687 0.647787438662773 0.83781860707593 0.357142857142857 19.4 19 4 decreased tongue size 0.41210999866687 0.647787438662773 0.83781860707593 0.357142857142857 19.4 19 4 abnormal respiratory motile cilium physiology 0.41210999866687 0.647787438662773 0.83781860707593 0.357142857142857 19.4 19 4 decreased inflammatory response 0.147382491466409 0.384895900345484 0.83781860707593 0.357142857142857 19.4 19 4 abnormal cytotoxic T cell physiology 0.25170650623324 0.515567933036579 0.83781860707593 0.357142857142857 19.4 19 4 increased B cell proliferation 0.205482716418341 0.472978234387655 0.834978544001097 0.355932203389831 19.4 19 4 abnormal cranial ganglia morphology 0.307103402522633 0.529030272697403 0.832413325739957 0.354838709677419 19.4 19 4 abnormal CD8-positive, alpha beta T cell morphology 0.307103402522633 0.529030272697403 0.832413325739957 0.354838709677419 19.4 19 4 abnormal urine homeostasis 0.141899003751735 0.376907391171853 0.830836785350298 0.354166666666667 19.4 19 4 abnormal thrombosis 0.24153523064902 0.515567933036579 0.827961917580919 0.352941176470588 19.4 19 4 abnormal retinal photoreceptor morphology 0.301639296253701 0.519977650333389 0.827961917580919 0.352941176470588 19.4 19 4 decreased pancreatic beta cell number 0.301639296253701 0.519977650333389 0.827961917580919 0.352941176470588 19.4 19 4 abnormal urinary bladder morphology 0.39915424340371 0.629810453832368 0.827961917580919 0.352941176470588 19.4 19 4 enlarged sebaceous gland 0.39915424340371 0.629810453832368 0.827961917580919 0.352941176470588 19.4 19 4 abnormal touch/ nociception 0.39915424340371 0.629810453832368 0.827961917580919 0.352941176470588 19.4 19 4 aminoaciduria 0.39915424340371 0.629810453832368 0.827961917580919 0.352941176470588 19.4 19 4 pancytopenia 0.39915424340371 0.629810453832368 0.827961917580919 0.352941176470588 19.4 19 4 abnormal tendon morphology 0.39915424340371 0.629810453832368 0.827961917580919 0.352941176470588 19.4 19 4 abnormal survival 0.39915424340371 0.629810453832368 0.827961917580919 0.352941176470588 19.4 19 4 abnormal T cell activation 0.193640462679622 0.45983833022965 0.824232359393618 0.351351351351351 19.4 19 4 abnormal pancreatic beta cell physiology 0.296339119542583 0.515567933036579 0.824232359393618 0.351351351351351 19.4 19 4 head bobbing 0.291198934743825 0.515567933036579 0.821062234934412 0.35 19.4 19 4 abnormal skin pigmentation 0.291198934743825 0.515567933036579 0.821062234934412 0.35 19.4 19 4 abnormal dopamine level 0.387659718738207 0.613424650357055 0.821062234934412 0.35 19.4 19 4 abnormal Peyer's patch T cell area morphology 0.387659718738207 0.613424650357055 0.821062234934412 0.35 19.4 19 4 abnormal intestinal mucosa morphology 0.286213058851327 0.515567933036579 0.818334453423002 0.348837209302326 19.4 19 4 impaired macrophage phagocytosis 0.286213058851327 0.515567933036579 0.818334453423002 0.348837209302326 19.4 19 4 abnormal blood vessel physiology 0.377265149848453 0.597546679559394 0.815962469500036 0.347826086956522 19.4 19 4 abnormal circulating insulin level 0.377265149848453 0.597546679559394 0.815962469500036 0.347826086956522 19.4 19 4 failure of embryo implantation 0.377265149848453 0.597546679559394 0.815962469500036 0.347826086956522 19.4 19 4 decreased epididymis weight 0.377265149848453 0.597546679559394 0.815962469500036 0.347826086956522 19.4 19 4 abnormal ulna morphology 0.377265149848453 0.597546679559394 0.815962469500036 0.347826086956522 19.4 19 4 abnormal hepatocyte physiology 0.377265149848453 0.597546679559394 0.815962469500036 0.347826086956522 19.4 19 4 abnormal leukocyte migration 0.272115621843079 0.515567933036579 0.812039573012055 0.346153846153846 19.4 19 4 ventricular hypoplasia 0.36773593850127 0.583754401417938 0.812039573012055 0.346153846153846 19.4 19 4 decreased Peyer's patch number 0.36773593850127 0.583754401417938 0.812039573012055 0.346153846153846 19.4 19 4 enlarged epididymis 0.3589101610789 0.570290019599977 0.808928310280209 0.344827586206897 19.4 19 4 impaired fertilization 0.247224651224533 0.515567933036579 0.804305862792893 0.342857142857143 19.4 19 4 abnormal photoreceptor outer segment morphology 0.322089339152419 0.553695391251999 0.799735943117934 0.340909090909091 19.4 19 4 increased eosinophil cell number 0.287884980653741 0.515567933036579 0.79457635638814 0.338709677419355 19.4 19 4 small lymph nodes 0.430504090207966 0.671187041298851 0.781964033270868 0.333333333333333 19.4 19 4 decreased fatty acid level 0.430504090207966 0.671187041298851 0.781964033270868 0.333333333333333 19.4 19 4 abnormal eye physiology 0.323755566046447 0.556367509872564 0.781964033270868 0.333333333333333 19.4 19 4 abnormal vibrissa morphology 0.36717821149803 0.583241252299712 0.781964033270868 0.333333333333333 19.4 19 4 abnormal lens fiber morphology 0.375875064545417 0.596484352827257 0.781964033270868 0.333333333333333 19.4 19 4 abnormal uterus morphology 0.385151456201813 0.60984356925653 0.781964033270868 0.333333333333333 19.4 19 4 liver hemorrhage 0.405859127002435 0.640186796714366 0.781964033270868 0.333333333333333 19.4 19 4 cryptorchism 0.417582796899302 0.655768438943822 0.781964033270868 0.333333333333333 19.4 19 4 decreased susceptibility to pharmacologically induced seizures 0.417582796899302 0.655768438943822 0.781964033270868 0.333333333333333 19.4 19 4 abnormal single cell response 0.417582796899302 0.655768438943822 0.781964033270868 0.333333333333333 19.4 19 4 dry skin 0.444948952867084 0.68540352843165 0.781964033270868 0.333333333333333 19.4 19 4 vascular ring 0.444948952867084 0.68540352843165 0.781964033270868 0.333333333333333 19.4 19 4 decreased salivation 0.480647719122626 0.700091754683471 0.781964033270868 0.333333333333333 19.4 19 4 abnormal retinal rod cell morphology 0.461404772095461 0.700091754683471 0.781964033270868 0.333333333333333 19.4 19 4 vagina atresia 0.480647719122626 0.700091754683471 0.781964033270868 0.333333333333333 19.4 19 4 abnormal Peyer's patch follicle morphology 0.461404772095461 0.700091754683471 0.781964033270868 0.333333333333333 19.4 19 4 abnormal white adipose tissue morphology 0.461404772095461 0.700091754683471 0.781964033270868 0.333333333333333 19.4 19 4 decreased activity of thyroid 0.461404772095461 0.700091754683471 0.781964033270868 0.333333333333333 19.4 19 4 abnormal zygomatic bone morphology 0.480647719122626 0.700091754683471 0.781964033270868 0.333333333333333 19.4 19 4 decreased trabecular bone mass 0.480647719122626 0.700091754683471 0.781964033270868 0.333333333333333 19.4 19 4 decreased fluid intake 0.461404772095461 0.700091754683471 0.781964033270868 0.333333333333333 19.4 19 4 impaired natural killer cell mediated cytotoxicity 0.330165453516845 0.5568980672227 0.781964033270868 0.333333333333333 19.4 19 4 abnormal skeleton physiology 0.395104298490697 0.624807337886591 0.781964033270868 0.333333333333333 19.4 19 4 abnormal T cell subpopulation ratio 0.395104298490697 0.624807337886591 0.781964033270868 0.333333333333333 19.4 19 4 increased neutrophil cell number 0.223042022960771 0.487751237024103 0.776571177869 0.331034482758621 19.4 19 4 increased white adipose tissue amount 0.427781377798243 0.667360412212687 0.760829870209494 0.324324324324324 19.4 19 4 abnormal bone remodeling 0.439804951734478 0.68540352843165 0.758965091115843 0.323529411764706 19.4 19 4 autoimmune response 0.452885662469007 0.696477950783094 0.756739387036324 0.32258064516129 19.4 19 4 decreased acute inflammation 0.483203158335203 0.700091754683471 0.750685471940034 0.32 19.4 19 4 abnormal myelopoiesis 0.445546735868936 0.68540352843165 0.746420213576738 0.318181818181818 19.4 19 4 abnormal gametogenesis 0.445546735868936 0.68540352843165 0.746420213576738 0.318181818181818 19.4 19 4 flaky skin 0.521838534067705 0.718159531669939 0.74080803151977 0.315789473684211 19.4 19 4 abnormal ear morphology 0.521838534067705 0.718159531669939 0.74080803151977 0.315789473684211 19.4 19 4 mixed cellular infiltration to dermis 0.546176754207262 0.744854537330353 0.733091281191439 0.3125 19.4 19 4 decreased cochlear coiling 0.546176754207262 0.744854537330353 0.733091281191439 0.3125 19.4 19 4 abnormal wound healing 0.546176754207262 0.744854537330353 0.733091281191439 0.3125 19.4 19 4 sepsis 0.546176754207262 0.744854537330353 0.733091281191439 0.3125 19.4 19 4 decreased circulating growth hormone level 0.546176754207262 0.744854537330353 0.733091281191439 0.3125 19.4 19 4 abnormal Langerhans cell physiology 0.546176754207262 0.744854537330353 0.733091281191439 0.3125 19.4 19 4 abnormal urinary bladder physiology 0.546176754207262 0.744854537330353 0.733091281191439 0.3125 19.4 19 4 increased heart left ventricle size 0.546176754207262 0.744854537330353 0.733091281191439 0.3125 19.4 19 4 abnormal sleep pattern 0.523184006275155 0.719812066155668 0.713967160812532 0.304347826086957 19.4 19 4 bidirectional circling 0.555399113244412 0.757224058205248 0.713967160812532 0.304347826086957 19.4 19 4 diarrhea 0.544669886316245 0.744432056160253 0.710876393882607 0.303030303030303 19.4 19 4 waved hair 0.57934374063749 0.777092237711381 0.703767629943781 0.3 19.4 19 4 decreased skin tensile strength 0.57934374063749 0.777092237711381 0.703767629943781 0.3 19.4 19 4 increased urine calcium level 0.57934374063749 0.777092237711381 0.703767629943781 0.3 19.4 19 4 decreased regulatory T cell number 0.588363609058648 0.788765549735051 0.689968264650766 0.294117647058824 19.4 19 4 decreased cytotoxic T cell cytolysis 0.588363609058648 0.788765549735051 0.689968264650766 0.294117647058824 19.4 19 4 distended urinary bladder 0.607436133708742 0.813019845359428 0.689968264650766 0.294117647058824 19.4 19 4 nephrocalcinosis 0.607436133708742 0.813019845359428 0.689968264650766 0.294117647058824 19.4 19 4 abnormal duodenum morphology 0.607436133708742 0.813019845359428 0.689968264650766 0.294117647058824 19.4 19 4 abnormal circulating chemokine level 0.607436133708742 0.813019845359428 0.689968264650766 0.294117647058824 19.4 19 4 abnormal adrenal gland morphology 0.606826475671183 0.813019845359428 0.68421852911201 0.291666666666667 19.4 19 4 abnormal cellular extravasation 0.606826475671183 0.813019845359428 0.68421852911201 0.291666666666667 19.4 19 4 abnormal body temperature homeostasis 0.608336152703486 0.814005475981668 0.681065448332692 0.290322580645161 19.4 19 4 abnormal stria vascularis morphology 0.63036362462641 0.83535519523459 0.670254885660744 0.285714285714286 19.4 19 4 increased vasoconstriction 0.633101655745651 0.83535519523459 0.670254885660744 0.285714285714286 19.4 19 4 impaired behavioral response to xenobiotic 0.630026663135717 0.83535519523459 0.670254885660744 0.285714285714286 19.4 19 4 abnormal feces composition 0.654902210190731 0.83535519523459 0.656849787947529 0.28 19.4 19 4 impaired conditioned place preference behavior 0.654902210190731 0.83535519523459 0.656849787947529 0.28 19.4 19 4 abnormal stomach mucosa morphology 0.654902210190731 0.83535519523459 0.656849787947529 0.28 19.4 19 4 abnormal stomach glandular epithelium morphology 0.663602042021542 0.842896625844953 0.65163669439239 0.277777777777778 19.4 19 4 abnormal radius morphology 0.663602042021542 0.842896625844953 0.65163669439239 0.277777777777778 19.4 19 4 abnormal systemic arterial blood pressure 0.669348471403988 0.844108655319352 0.65163669439239 0.277777777777778 19.4 19 4 increased susceptibility to parasitic infection 0.70605578266028 0.885685203917018 0.65163669439239 0.277777777777778 19.4 19 4 decreased retinal photoreceptor cell number 0.673930150673815 0.849240754711811 0.647142648224167 0.275862068965517 19.4 19 4 increased susceptibility to induced arthritis 0.673930150673815 0.849240754711811 0.647142648224167 0.275862068965517 19.4 19 4 abnormal CD8-positive, alpha-beta T cell physiology 0.673930150673815 0.849240754711811 0.647142648224167 0.275862068965517 19.4 19 4 increased activated T cell number 0.682570615875546 0.859383536403382 0.639788754494347 0.272727272727273 19.4 19 4 abnormal tectorial membrane morphology 0.699252842422007 0.877815516288036 0.631586334564932 0.269230769230769 19.4 19 4 abnormal photoreceptor inner segment morphology 0.71423186629077 0.895489802116074 0.617340026266475 0.263157894736842 19.4 19 4 increased left ventricle weight 0.71423186629077 0.895489802116074 0.617340026266475 0.263157894736842 19.4 19 4 abnormal retinal cone cell morphology 0.727454675627711 0.911608818954122 0.611971852125027 0.260869565217391 19.4 19 4 abnormal regulatory T cell physiology 0.727454675627711 0.911608818954122 0.611971852125027 0.260869565217391 19.4 19 4 abnormal fibula morphology 0.759194574841864 0.920095739302868 0.586473024953151 0.25 19.4 19 4 increased susceptibility to weight loss 0.799958773401573 0.965883322972476 0.586473024953151 0.25 19.4 19 4 abnormal intestine physiology 0.862551580918001 1 0.529717570925427 0.225806451612903 19.4 19 4 head tilt 0.885006156346061 1 0.521309355513912 0.222222222222222 19.4 19 4 decreased susceptibility to parasitic infection 0.884446079912647 1 0.513163896834007 0.21875 19.4 19 4 increased susceptibility to fungal infection 0.861966109307282 1 0.509976543437523 0.217391304347826 19.4 19 4 lethality during fetal growth through weaning, complete penetrance 6.54670499227297e-05 0.00104390568386404 1.62001853568119 1 2.1 2 1 small hair follicles 0.00809600473063529 0.0574573802209851 1.62001853568119 1 2.1 2 1 abnormal respiratory sounds 0.00809600473063529 0.0574573802209851 1.62001853568119 1 2.1 2 1 increased lysosomal enzyme secretion 0.00809600473063529 0.0574573802209851 1.62001853568119 1 2.1 2 1 gastric polyps 0.00809600473063529 0.0574573802209851 1.62001853568119 1 2.1 2 1 abnormal response to vitamins 0.00809600473063529 0.0574573802209851 1.62001853568119 1 2.1 2 1 abnormal inner cell mass proliferation 0.00809600473063529 0.0574573802209851 1.62001853568119 1 2.1 2 1 abnormal mismatch repair 0.00809600473063529 0.0574573802209851 1.62001853568119 1 2.1 2 1 increased response to stress-induced hyperthermia 0.00809600473063529 0.0574573802209851 1.62001853568119 1 2.1 2 1 increased T follicular helper cell number 0.00809600473063529 0.0574573802209851 1.62001853568119 1 2.1 2 1 increased renal carcinoma incidence 0.00809600473063529 0.0574573802209851 1.62001853568119 1 2.1 2 1 aorta hypoplasia 0.00809600473063529 0.0574573802209851 1.62001853568119 1 2.1 2 1 increased CD4-positive, alpha-beta memory T cell number 0.00809600473063529 0.0574573802209851 1.62001853568119 1 2.1 2 1 midface hypoplasia 0.00809600473063529 0.0574573802209851 1.62001853568119 1 2.1 2 1 loss of cortex neurons 2.49753108421382e-05 0.000440560827757997 1.62001853568119 1 2.1 2 1 liver hyperplasia 0.000171598655083807 0.00238464611464229 1.62001853568119 1 2.1 2 1 abnormal leukopoiesis 0.000171598655083807 0.00238464611464229 1.62001853568119 1 2.1 2 1 elevated level of mitotic sister chromatid exchange 0.00044976352286108 0.00544421782538656 1.62001853568119 1 2.1 2 1 abnormal meiotic spindle morphology 0.00044976352286108 0.00544421782538656 1.62001853568119 1 2.1 2 1 abnormal mitotic spindle assembly checkpoint 0.00044976352286108 0.00544421782538656 1.62001853568119 1 2.1 2 1 abnormal macrophage activation involved in immune response 0.00044976352286108 0.00544421782538656 1.62001853568119 1 2.1 2 1 increased brain apoptosis 0.00044976352286108 0.00544421782538656 1.62001853568119 1 2.1 2 1 absent ectoplacental cone 0.00308931835338932 0.0269637873826524 1.62001853568119 1 2.1 2 1 abnormal leukocyte tethering or rolling 0.00308931835338932 0.0269637873826524 1.62001853568119 1 2.1 2 1 absent cochlear nerve compound action potential 0.00308931835338932 0.0269637873826524 1.62001853568119 1 2.1 2 1 abnormal immature B cell morphology 0.00308931835338932 0.0269637873826524 1.62001853568119 1 2.1 2 1 abnormal vertebral artery origin 0.00308931835338932 0.0269637873826524 1.62001853568119 1 2.1 2 1 abnormal circulating alanine transaminase level 0.00117878289196192 0.0122034203275683 1.62001853568119 1 2.1 2 1 decreased mortality induced by ionizing radiation 0.00117878289196192 0.0122034203275683 1.62001853568119 1 2.1 2 1 heart hemorrhage 0.00117878289196192 0.0122034203275683 1.62001853568119 1 2.1 2 1 increased DN3 thymocyte number 0.00117878289196192 0.0122034203275683 1.62001853568119 1 2.1 2 1 decreased CD8-positive, naive alpha-beta T cell number 0.00117878289196192 0.0122034203275683 1.62001853568119 1 2.1 2 1 abnormal thymocyte activation 1.42672231698042e-07 4.16943180905085e-06 1.53901760889713 0.95 2.1 2 1 increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 3.55969000935322e-07 9.78423082681342e-06 1.53475440222428 0.947368421052632 2.1 2 1 increased effector memory CD4-positive, alpha-beta T cell number 8.85796894320124e-07 2.2952289318972e-05 1.53001750592112 0.944444444444444 2.1 2 1 increased B cell derived lymphoma incidence 1.00395723970471e-16 1.28068904295665e-14 1.52281742354032 0.94 2.1 2 1 increased fibroblast apoptosis 5.46704837180859e-11 3.12627191376411e-09 1.51876737720111 0.9375 2.1 2 1 abnormal positive T cell selection 3.28590505819352e-05 0.000559841700839477 1.50430292598967 0.928571428571429 2.1 2 1 testis degeneration 3.28590505819352e-05 0.000559841700839477 1.50430292598967 0.928571428571429 2.1 2 1 decreased response to antigen 3.28590505819352e-05 0.000559841700839477 1.50430292598967 0.928571428571429 2.1 2 1 abnormal telomere length 8.02452923769615e-05 0.00123597625255537 1.49540172524417 0.923076923076923 2.1 2 1 increased hemangiosarcoma incidence 6.91262209918927e-08 2.21872870603011e-06 1.48501699104109 0.916666666666667 2.1 2 1 increased osteosarcoma incidence 0.000194901395897179 0.00263487620812083 1.48501699104109 0.916666666666667 2.1 2 1 abnormal dorsal-ventral polarity of the somites 0.000470384440728644 0.005666253250908 1.47274412334653 0.909090909090909 2.1 2 1 increased number of Howell-Jolly bodies 0.000470384440728644 0.005666253250908 1.47274412334653 0.909090909090909 2.1 2 1 abnormal cytotoxic T cell physiology 2.15454919544854e-12 1.5312688924795e-10 1.4657310560925 0.904761904761905 2.1 2 1 abnormal T cell proliferation 2.16260161819584e-09 9.35560265262983e-08 1.4632425483572 0.903225806451613 2.1 2 1 spleen atrophy 2.27563992407084e-06 5.36554911007223e-05 1.45801668211307 0.9 2.1 2 1 acanthocytosis 0.0011267831015335 0.0118765803604431 1.45801668211307 0.9 2.1 2 1 arrested T cell differentiation 5.13577393828624e-09 2.11541491799645e-07 1.45801668211307 0.9 2.1 2 1 abnormal chromosome morphology 1.59703088233178e-10 8.2762798329173e-09 1.44488139668863 0.891891891891892 2.1 2 1 absent inner cell mass 1.26934777403914e-05 0.000249604947661847 1.44001647616105 0.888888888888889 2.1 2 1 heart hyperplasia 0.00267508246507928 0.0239362145031824 1.44001647616105 0.888888888888889 2.1 2 1 abnormal gut-associated lymphoid tissue morphology 0.00267508246507928 0.0239362145031824 1.44001647616105 0.888888888888889 2.1 2 1 genetic imprinting 0.00267508246507928 0.0239362145031824 1.44001647616105 0.888888888888889 2.1 2 1 increased neuronal precursor cell number 0.00267508246507928 0.0239362145031824 1.44001647616105 0.888888888888889 2.1 2 1 abnormal lung lobe morphology 0.00267508246507928 0.0239362145031824 1.44001647616105 0.888888888888889 2.1 2 1 increased myeloid cell number 0.00267508246507928 0.0239362145031824 1.44001647616105 0.888888888888889 2.1 2 1 symmetric azygos veins 0.00267508246507928 0.0239362145031824 1.44001647616105 0.888888888888889 2.1 2 1 decreased platelet dense granule number 0.00267508246507928 0.0239362145031824 1.44001647616105 0.888888888888889 2.1 2 1 increased T cell derived lymphoma incidence 8.46598015037746e-13 6.38155321941331e-11 1.42164891906716 0.877551020408163 2.1 2 1 increased cochlear outer hair cell number 6.90873236153454e-05 0.00107745904384434 1.41751621872104 0.875 2.1 2 1 increased sensitivity to skin irradiation 0.00628191847566784 0.0483785517282469 1.41751621872104 0.875 2.1 2 1 colon polyps 0.00628191847566784 0.0483785517282469 1.41751621872104 0.875 2.1 2 1 accumulation of giant lysosomes in kidney/renal tubule cells 0.00628191847566784 0.0483785517282469 1.41751621872104 0.875 2.1 2 1 abnormal NK cell morphology 0.00628191847566784 0.0483785517282469 1.41751621872104 0.875 2.1 2 1 abnormal choroid pigmentation 0.00628191847566784 0.0483785517282469 1.41751621872104 0.875 2.1 2 1 abnormal base-excision repair 0.00628191847566784 0.0483785517282469 1.41751621872104 0.875 2.1 2 1 pleural effusion 0.00628191847566784 0.0483785517282469 1.41751621872104 0.875 2.1 2 1 lung situs inversus 0.00628191847566784 0.0483785517282469 1.41751621872104 0.875 2.1 2 1 lethality during fetal growth through weaning, incomplete penetrance 0.00628191847566784 0.0483785517282469 1.41751621872104 0.875 2.1 2 1 small thymus medulla 0.00628191847566784 0.0483785517282469 1.41751621872104 0.875 2.1 2 1 decreased B-1 B cell number 3.33851636053748e-10 1.64446721719544e-08 1.4123238516195 0.871794871794872 2.1 2 1 abnormal hematopoietic stem cell physiology 1.95545364057555e-06 4.63256279136351e-05 1.40871177015755 0.869565217391304 2.1 2 1 abnormal placenta size 0.000159397504342573 0.00227221370803524 1.40401606425703 0.866666666666667 2.1 2 1 increased adenoma incidence 4.47880283159248e-06 0.000100369567960237 1.39910691717921 0.863636363636364 2.1 2 1 increased hemangioma incidence 0.00036456274314712 0.00456180998151669 1.38858731629816 0.857142857142857 2.1 2 1 mammary gland hyperplasia 0.0145525311219537 0.0904985529146495 1.38858731629816 0.857142857142857 2.1 2 1 decreased activated T cell number 0.0145525311219537 0.0904985529146495 1.38858731629816 0.857142857142857 2.1 2 1 abnormal tumor incidence 0.0145525311219537 0.0904985529146495 1.38858731629816 0.857142857142857 2.1 2 1 abnormal gastrulation movements 0.0145525311219537 0.0904985529146495 1.38858731629816 0.857142857142857 2.1 2 1 decreased cardiomyocyte apoptosis 0.0145525311219537 0.0904985529146495 1.38858731629816 0.857142857142857 2.1 2 1 aorta coarctation 0.0145525311219537 0.0904985529146495 1.38858731629816 0.857142857142857 2.1 2 1 abnormal negative T cell selection 0.0145525311219537 0.0904985529146495 1.38858731629816 0.857142857142857 2.1 2 1 increased chronic myelocytic leukemia incidence 0.0145525311219537 0.0904985529146495 1.38858731629816 0.857142857142857 2.1 2 1 increased keratinocyte apoptosis 0.0145525311219537 0.0904985529146495 1.38858731629816 0.857142857142857 2.1 2 1 absent popliteal lymph nodes 0.0145525311219537 0.0904985529146495 1.38858731629816 0.857142857142857 2.1 2 1 increased tumor latency 0.0145525311219537 0.0904985529146495 1.38858731629816 0.857142857142857 2.1 2 1 abnormal sperm annulus morphology 0.0145525311219537 0.0904985529146495 1.38858731629816 0.857142857142857 2.1 2 1 decreased DN2 thymocyte number 0.0145525311219537 0.0904985529146495 1.38858731629816 0.857142857142857 2.1 2 1 decreased DN4 thymocyte number 0.0145525311219537 0.0904985529146495 1.38858731629816 0.857142857142857 2.1 2 1 arteritis 0.0145525311219537 0.0904985529146495 1.38858731629816 0.857142857142857 2.1 2 1 decreased T-helper 17 cell number 0.0145525311219537 0.0904985529146495 1.38858731629816 0.857142857142857 2.1 2 1 embryonic lethality at implantation, incomplete penetrance 0.0145525311219537 0.0904985529146495 1.38858731629816 0.857142857142857 2.1 2 1 ductus venosus stenosis 0.0145525311219537 0.0904985529146495 1.38858731629816 0.857142857142857 2.1 2 1 absent connection between subcutaneous lymph vessels and lymph sac 0.0145525311219537 0.0904985529146495 1.38858731629816 0.857142857142857 2.1 2 1 abnormal spleen red pulp morphology 2.03649594907732e-08 7.28889737169761e-07 1.38178051572807 0.852941176470588 2.1 2 1 abnormal cell cycle 2.32712293957608e-25 8.26959758885071e-23 1.3805375347544 0.852173913043478 2.1 2 1 increased skin tumor incidence 2.30336003508716e-05 0.000413690114605005 1.37701575532901 0.85 2.1 2 1 abnormal T cell subpopulation ratio 4.57350016479798e-08 1.52705794093087e-06 1.3745611817901 0.848484848484849 2.1 2 1 abnormal B cell differentiation 7.91869951229287e-20 1.51521269514065e-17 1.37078491480716 0.846153846153846 2.1 2 1 increased thymocyte apoptosis 1.51600942554902e-06 3.71534329660413e-05 1.37078491480716 0.846153846153846 2.1 2 1 increased pituitary adenoma incidence 0.000825509965258376 0.00906603107540932 1.37078491480716 0.846153846153846 2.1 2 1 abnormal exocrine pancreas morphology 0.000825509965258376 0.00906603107540932 1.37078491480716 0.846153846153846 2.1 2 1 decreased tumor incidence 5.16489110859937e-05 0.000850838849843771 1.36422613531047 0.842105263157895 2.1 2 1 increased cellular sensitivity to ionizing radiation 3.38103242730463e-06 7.6806558565482e-05 1.3608155699722 0.84 2.1 2 1 abnormal erythropoiesis 7.02390340654509e-22 1.66399616416961e-19 1.35772982038042 0.838095238095238 2.1 2 1 abnormal T cell activation 8.39646519124937e-16 9.28275873921458e-14 1.35731282719235 0.837837837837838 2.1 2 1 abnormal apoptosis 1.1535270410429e-11 7.09952162604652e-10 1.35001544640099 0.833333333333333 2.1 2 1 underdeveloped hair follicles 0.000114821593646677 0.00169005156329059 1.35001544640099 0.833333333333333 2.1 2 1 small thoracic cage 0.000114821593646677 0.00169005156329059 1.35001544640099 0.833333333333333 2.1 2 1 increased gastrointestinal tumor incidence 0.000114821593646677 0.00169005156329059 1.35001544640099 0.833333333333333 2.1 2 1 increased effector memory CD8-positive, alpha-beta T cell number 0.000114821593646677 0.00169005156329059 1.35001544640099 0.833333333333333 2.1 2 1 interstitial pneumonia 0.00184779966488597 0.0177125305063732 1.35001544640099 0.833333333333333 2.1 2 1 increased papilloma incidence 0.00184779966488597 0.0177125305063732 1.35001544640099 0.833333333333333 2.1 2 1 increased fibrosarcoma incidence 0.00184779966488597 0.0177125305063732 1.35001544640099 0.833333333333333 2.1 2 1 prenatal growth retardation 0.00184779966488597 0.0177125305063732 1.35001544640099 0.833333333333333 2.1 2 1 abnormal vitelline vein connection 0.00184779966488597 0.0177125305063732 1.35001544640099 0.833333333333333 2.1 2 1 echinocytosis 0.0331294366168651 0.168011159193582 1.35001544640099 0.833333333333333 2.1 2 1 epidermal necrosis 0.0331294366168651 0.168011159193582 1.35001544640099 0.833333333333333 2.1 2 1 delayed brain development 0.0331294366168651 0.168011159193582 1.35001544640099 0.833333333333333 2.1 2 1 non-obstructive hydrocephaly 0.0331294366168651 0.168011159193582 1.35001544640099 0.833333333333333 2.1 2 1 abnormal lymph organ size 0.0331294366168651 0.168011159193582 1.35001544640099 0.833333333333333 2.1 2 1 abnormal lymph node cortex morphology 0.0331294366168651 0.168011159193582 1.35001544640099 0.833333333333333 2.1 2 1 abnormal cervical lymph node morphology 0.0331294366168651 0.168011159193582 1.35001544640099 0.833333333333333 2.1 2 1 increased post-tetanic potentiation 0.0331294366168651 0.168011159193582 1.35001544640099 0.833333333333333 2.1 2 1 abnormal hippocampal fimbria morphology 0.0331294366168651 0.168011159193582 1.35001544640099 0.833333333333333 2.1 2 1 bile duct inflammation 0.0331294366168651 0.168011159193582 1.35001544640099 0.833333333333333 2.1 2 1 esophageal atresia 0.0331294366168651 0.168011159193582 1.35001544640099 0.833333333333333 2.1 2 1 decreased liver function 0.0331294366168651 0.168011159193582 1.35001544640099 0.833333333333333 2.1 2 1 enlarged pancreas 0.0331294366168651 0.168011159193582 1.35001544640099 0.833333333333333 2.1 2 1 rheumatoid arthritis 0.0331294366168651 0.168011159193582 1.35001544640099 0.833333333333333 2.1 2 1 abnormal cholesterol level 0.0331294366168651 0.168011159193582 1.35001544640099 0.833333333333333 2.1 2 1 abnormal physical strength 0.0331294366168651 0.168011159193582 1.35001544640099 0.833333333333333 2.1 2 1 absent parietal bone 0.0331294366168651 0.168011159193582 1.35001544640099 0.833333333333333 2.1 2 1 abnormal T cell clonal deletion 0.0331294366168651 0.168011159193582 1.35001544640099 0.833333333333333 2.1 2 1 impaired granulocyte bactericidal activity 0.0331294366168651 0.168011159193582 1.35001544640099 0.833333333333333 2.1 2 1 abnormal heart size 0.0331294366168651 0.168011159193582 1.35001544640099 0.833333333333333 2.1 2 1 decreased platelet ADP level 0.0331294366168651 0.168011159193582 1.35001544640099 0.833333333333333 2.1 2 1 delayed chorioallantoic fusion 0.0331294366168651 0.168011159193582 1.35001544640099 0.833333333333333 2.1 2 1 increased transitional stage T1 B cell number 0.0331294366168651 0.168011159193582 1.35001544640099 0.833333333333333 2.1 2 1 abnormal oval cell physiology 0.0331294366168651 0.168011159193582 1.35001544640099 0.833333333333333 2.1 2 1 decreased DN1 thymic pro-T cell number 0.0331294366168651 0.168011159193582 1.35001544640099 0.833333333333333 2.1 2 1 kidney microaneurysm 0.0331294366168651 0.168011159193582 1.35001544640099 0.833333333333333 2.1 2 1 myocardium hypoplasia 0.0331294366168651 0.168011159193582 1.35001544640099 0.833333333333333 2.1 2 1 absent third pharyngeal arch 0.0331294366168651 0.168011159193582 1.35001544640099 0.833333333333333 2.1 2 1 abnormal endocrine pancreas development 0.0331294366168651 0.168011159193582 1.35001544640099 0.833333333333333 2.1 2 1 delayed limb development 0.0331294366168651 0.168011159193582 1.35001544640099 0.833333333333333 2.1 2 1 thymus cortex atrophy 0.0331294366168651 0.168011159193582 1.35001544640099 0.833333333333333 2.1 2 1 increased CD11b-high dendritic cell number 0.0331294366168651 0.168011159193582 1.35001544640099 0.833333333333333 2.1 2 1 increased effector memory T-helper cell number 0.0331294366168651 0.168011159193582 1.35001544640099 0.833333333333333 2.1 2 1 additional anastomosis between intracranial vertebral arteries 0.0331294366168651 0.168011159193582 1.35001544640099 0.833333333333333 2.1 2 1 decreased tear production 0.0331294366168651 0.168011159193582 1.35001544640099 0.833333333333333 2.1 2 1 increased embryonic tissue cell apoptosis 2.89536780397091e-16 3.34987321505937e-14 1.35001544640099 0.833333333333333 2.1 2 1 decreased double-positive T cell number 3.60971342980181e-20 7.48263513052666e-18 1.34461538461538 0.83 2.1 2 1 increased cellular sensitivity to gamma-irradiation 3.6113850549311e-10 1.74433404352255e-08 1.34427069982056 0.829787234042553 2.1 2 1 arrested B cell differentiation 5.18755015066467e-09 2.11541491799645e-07 1.34343000519903 0.829268292682927 2.1 2 1 increased mortality induced by gamma-irradiation 1.10266703565992e-06 2.75666758914981e-05 1.3407049950465 0.827586206896552 2.1 2 1 abnormal B cell morphology 1.64647114889229e-05 0.000307939622772147 1.33827618164968 0.826086956521739 2.1 2 1 abnormal ectoplacental cone morphology 0.000252825625326908 0.00332753303174965 1.33413291173745 0.823529411764706 2.1 2 1 lymphoid hyperplasia 2.40630219706155e-06 5.64686482565152e-05 1.3307295114524 0.821428571428571 2.1 2 1 small liver 2.21521452232488e-15 2.24912086705434e-13 1.32924597799482 0.82051282051282 2.1 2 1 increased double-negative T cell number 2.82720278520479e-12 1.90072079140457e-10 1.32788404564032 0.819672131147541 2.1 2 1 abnormal thrombopoiesis 0.00408057707515535 0.0341191108384838 1.32546971101188 0.818181818181818 2.1 2 1 abnormal proximal-distal axis patterning 0.00408057707515535 0.0341191108384838 1.32546971101188 0.818181818181818 2.1 2 1 reduced sympathetic cervical ganglion size 0.00408057707515535 0.0341191108384838 1.32546971101188 0.818181818181818 2.1 2 1 increased tumor incidence 5.33319759359296e-23 1.47403655711806e-20 1.31953122664355 0.814516129032258 2.1 2 1 intraventricular hemorrhage 0.000550741620827227 0.0062987116404953 1.31626506024096 0.8125 2.1 2 1 increased intestinal adenocarcinoma incidence 0.000550741620827227 0.0062987116404953 1.31626506024096 0.8125 2.1 2 1 decreased liver cholesterol level 0.000550741620827227 0.0062987116404953 1.31626506024096 0.8125 2.1 2 1 abnormal T cell differentiation 9.09779245904493e-19 1.56074198219823e-16 1.31526257352334 0.811881188118812 2.1 2 1 increased incidence of induced tumors 7.76072787408258e-05 0.00120279193687105 1.31144357650382 0.80952380952381 2.1 2 1 inner cell mass degeneration 1.64719593851578e-06 3.99746331420293e-05 1.30646656103321 0.806451612903226 2.1 2 1 abnormal CD8-positive, alpha beta T cell morphology 1.64719593851578e-06 3.99746331420293e-05 1.30646656103321 0.806451612903226 2.1 2 1 failure to gastrulate 5.53042215026377e-09 2.21885888690018e-07 1.30305838739574 0.804347826086957 2.1 2 1 embryonic lethality between implantation and placentation, complete penetrance 5.53042215026377e-09 2.21885888690018e-07 1.30305838739574 0.804347826086957 2.1 2 1 abnormal embryo turning 2.70021960130338e-10 1.37077474658003e-08 1.29601482854495 0.8 2.1 2 1 small gonad 0.000166110154026483 0.00234107086765369 1.29601482854495 0.8 2.1 2 1 increased mammary adenocarcinoma incidence 0.000166110154026483 0.00234107086765369 1.29601482854495 0.8 2.1 2 1 dilated vasculature 0.000166110154026483 0.00234107086765369 1.29601482854495 0.8 2.1 2 1 absent ductus venosus valve 0.000166110154026483 0.00234107086765369 1.29601482854495 0.8 2.1 2 1 abnormal immune cell physiology 0.00886827991926238 0.0616196823999027 1.29601482854495 0.8 2.1 2 1 rhinitis 0.00886827991926238 0.0616196823999027 1.29601482854495 0.8 2.1 2 1 bifid ureter 0.00886827991926238 0.0616196823999027 1.29601482854495 0.8 2.1 2 1 absent CD4-positive, alpha beta T cells 0.00886827991926238 0.0616196823999027 1.29601482854495 0.8 2.1 2 1 abnormal corneal endothelium morphology 0.00886827991926238 0.0616196823999027 1.29601482854495 0.8 2.1 2 1 ascites 0.00886827991926238 0.0616196823999027 1.29601482854495 0.8 2.1 2 1 osteosclerosis 0.00886827991926238 0.0616196823999027 1.29601482854495 0.8 2.1 2 1 increased circulating fructosamine level 0.00886827991926238 0.0616196823999027 1.29601482854495 0.8 2.1 2 1 abnormal left subclavian artery morphology 0.00886827991926238 0.0616196823999027 1.29601482854495 0.8 2.1 2 1 abnormal inferior vena cava valve morphology 0.00886827991926238 0.0616196823999027 1.29601482854495 0.8 2.1 2 1 spleen hyperplasia 1.48569908890398e-13 1.34388235769041e-11 1.29601482854495 0.8 2.1 2 1 abnormal spleen marginal zone morphology 3.50535695734142e-06 7.92688675580618e-05 1.29601482854495 0.8 2.1 2 1 decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 2.39204926603921e-05 0.000425348231994032 1.29601482854495 0.8 2.1 2 1 absent egg cylinders 0.00118522369836531 0.0122034203275683 1.29601482854495 0.8 2.1 2 1 delayed intramembranous bone ossification 0.00118522369836531 0.0122034203275683 1.29601482854495 0.8 2.1 2 1 immune system phenotype 0.00118522369836531 0.0122034203275683 1.29601482854495 0.8 2.1 2 1 abnormal dendritic cell morphology 0.00118522369836531 0.0122034203275683 1.29601482854495 0.8 2.1 2 1 decreased thymocyte apoptosis 0.00118522369836531 0.0122034203275683 1.29601482854495 0.8 2.1 2 1 increased sarcoma incidence 3.74306742342158e-09 1.59160345568567e-07 1.28940250799115 0.795918367346939 2.1 2 1 embryonic lethality between implantation and somite formation, complete penetrance 2.66483166240771e-40 1.65719219005979e-37 1.28940250799115 0.795918367346939 2.1 2 1 abnormal direction of heart looping 1.09740679486512e-06 2.75666758914981e-05 1.28648530774682 0.794117647058823 2.1 2 1 abnormal embryonic erythropoiesis 7.40357031576782e-06 0.000156735158812532 1.28484228691956 0.793103448275862 2.1 2 1 abnormal double-strand DNA break repair 5.1846823349884e-08 1.69696017214259e-06 1.28094488867815 0.790697674418605 2.1 2 1 increased hepatocellular carcinoma incidence 3.80867039855454e-10 1.80458430788655e-08 1.27896200185357 0.789473684210526 2.1 2 1 increased malignant tumor incidence 0.000351719153249241 0.00441869390761357 1.27896200185357 0.789473684210526 2.1 2 1 abnormal cell nucleus morphology 1.63876778967426e-08 6.08423115942496e-07 1.2753337408554 0.787234042553192 2.1 2 1 abnormal NK cell physiology 1.2143925212731e-10 6.42723701418478e-09 1.2747686838147 0.786885245901639 2.1 2 1 abnormal mitotic spindle morphology 1.55106964529541e-05 0.000293405759899036 1.27287170660665 0.785714285714286 2.1 2 1 subcutaneous edema 1.55106964529541e-05 0.000293405759899036 1.27287170660665 0.785714285714286 2.1 2 1 abnormal spleen periarteriolar lymphoid sheath morphology 0.00251564977966631 0.0233030575903884 1.27287170660665 0.785714285714286 2.1 2 1 abnormal ventral body wall morphology 0.00251564977966631 0.0233030575903884 1.27287170660665 0.785714285714286 2.1 2 1 abnormal vascular endothelial cell migration 0.00251564977966631 0.0233030575903884 1.27287170660665 0.785714285714286 2.1 2 1 vascular smooth muscle hypoplasia 0.00251564977966631 0.0233030575903884 1.27287170660665 0.785714285714286 2.1 2 1 abnormal maternal decidual layer morphology 0.00251564977966631 0.0233030575903884 1.27287170660665 0.785714285714286 2.1 2 1 increased stomach tumor incidence 0.00251564977966631 0.0233030575903884 1.27287170660665 0.785714285714286 2.1 2 1 abnormal vitelline vein topology 0.00251564977966631 0.0233030575903884 1.27287170660665 0.785714285714286 2.1 2 1 increased T cell proliferation 1.75561112435541e-17 2.64671677080853e-15 1.27179025231046 0.785046728971963 2.1 2 1 abnormal definitive hematopoiesis 2.26610339034921e-15 2.25477287339746e-13 1.271627452739 0.78494623655914 2.1 2 1 impaired hematopoiesis 5.18376608803978e-09 2.11541491799645e-07 1.27060277308328 0.784313725490196 2.1 2 1 abnormal cell death 3.40172646362616e-08 1.15914994222878e-06 1.2678405931418 0.782608695652174 2.1 2 1 abnormal lymphocyte physiology 3.40172646362616e-08 1.15914994222878e-06 1.2678405931418 0.782608695652174 2.1 2 1 abnormal embryonic hematopoiesis 4.78505863762507e-06 0.000106275297866896 1.26563948100093 0.78125 2.1 2 1 seminiferous tubule degeneration 3.93557900601135e-12 2.57625073090875e-10 1.26494597991545 0.780821917808219 2.1 2 1 abnormal developmental patterning 1.94596369284318e-13 1.66916713308531e-11 1.26440471077556 0.780487804878049 2.1 2 1 abnormal trophoblast giant cell morphology 1.48318897569487e-06 3.67107719108556e-05 1.26001441664092 0.777777777777778 2.1 2 1 decreased circulating fructosamine level 3.2213227274417e-05 0.000554535659827766 1.26001441664092 0.777777777777778 2.1 2 1 abnormal thymus cortex morphology 0.000735839736207719 0.00820807777496278 1.26001441664092 0.777777777777778 2.1 2 1 abnormal thymus medulla morphology 0.000735839736207719 0.00820807777496278 1.26001441664092 0.777777777777778 2.1 2 1 abnormal redox activity 0.000735839736207719 0.00820807777496278 1.26001441664092 0.777777777777778 2.1 2 1 decreased cellular sensitivity to gamma-irradiation 0.000735839736207719 0.00820807777496278 1.26001441664092 0.777777777777778 2.1 2 1 decreased tumor latency 0.000735839736207719 0.00820807777496278 1.26001441664092 0.777777777777778 2.1 2 1 abnormal hypoglossal nerve topology 0.000735839736207719 0.00820807777496278 1.26001441664092 0.777777777777778 2.1 2 1 abnormal cholinergic neuron morphology 0.0189058445127278 0.113732256893375 1.26001441664092 0.777777777777778 2.1 2 1 multifocal hepatic necrosis 0.0189058445127278 0.113732256893375 1.26001441664092 0.777777777777778 2.1 2 1 decreased level of surface class I molecules 0.0189058445127278 0.113732256893375 1.26001441664092 0.777777777777778 2.1 2 1 increased pheochromocytoma incidence 0.0189058445127278 0.113732256893375 1.26001441664092 0.777777777777778 2.1 2 1 abnormal germ cell morphology 0.0189058445127278 0.113732256893375 1.26001441664092 0.777777777777778 2.1 2 1 abnormal artery development 0.0189058445127278 0.113732256893375 1.26001441664092 0.777777777777778 2.1 2 1 decreased cellular sensitivity to ionizing radiation 0.0189058445127278 0.113732256893375 1.26001441664092 0.777777777777778 2.1 2 1 short frontal bone 0.0189058445127278 0.113732256893375 1.26001441664092 0.777777777777778 2.1 2 1 abnormal telomere morphology 0.0189058445127278 0.113732256893375 1.26001441664092 0.777777777777778 2.1 2 1 abnormal oxidative phosphorylation 0.0189058445127278 0.113732256893375 1.26001441664092 0.777777777777778 2.1 2 1 increased cardiac muscle glycogen level 0.0189058445127278 0.113732256893375 1.26001441664092 0.777777777777778 2.1 2 1 thymus hypoplasia 4.06873385063689e-21 8.80084822039936e-19 1.25610132839049 0.77536231884058 2.1 2 1 extramedullary hematopoiesis 2.06824105270438e-16 2.50963396029373e-14 1.25322188609299 0.773584905660377 2.1 2 1 abnormal germ layer development 0.000219393568137495 0.00291840374728352 1.25183250484455 0.772727272727273 2.1 2 1 increased mammary gland tumor incidence 0.000219393568137495 0.00291840374728352 1.25183250484455 0.772727272727273 2.1 2 1 embryonic lethality before implantation, incomplete penetrance 0.000219393568137495 0.00291840374728352 1.25183250484455 0.772727272727273 2.1 2 1 decreased B cell proliferation 1.67472961050182e-12 1.22526173709508e-10 1.25090038831079 0.772151898734177 2.1 2 1 abnormal cell morphology 2.11011777386546e-17 3.0875988014649e-15 1.2505406240346 0.771929824561403 2.1 2 1 increased carcinoma incidence 3.04631363058322e-06 7.01639366303311e-05 1.24972858466834 0.771428571428571 2.1 2 1 decreased bone resorption 6.62750380794386e-05 0.00105341314519236 1.24616810437014 0.769230769230769 2.1 2 1 tracheoesophageal fistula 0.00525543199697792 0.0418332386959442 1.24616810437014 0.769230769230769 2.1 2 1 increased cochlear inner hair cell number 0.00525543199697792 0.0418332386959442 1.24616810437014 0.769230769230769 2.1 2 1 absent hypoglossal nerve 0.00525543199697792 0.0418332386959442 1.24616810437014 0.769230769230769 2.1 2 1 impaired macrophage chemotaxis 9.44181770867987e-07 2.43383643008717e-05 1.24616810437014 0.769230769230769 2.1 2 1 increased metastatic potential 2.02119856363116e-05 0.000372424550150556 1.24201421068891 0.766666666666667 2.1 2 1 increased neuron apoptosis 2.19031636085448e-12 1.5347639289086e-10 1.24001418780535 0.765432098765432 2.1 2 1 decreased cytotoxic T cell cytolysis 6.20872490835266e-06 0.000133716045104132 1.2388377037562 0.764705882352941 2.1 2 1 abnormal interatrial septum morphology 0.00151896860620326 0.0151440256830886 1.2388377037562 0.764705882352941 2.1 2 1 abnormal embryonic-extraembryonic boundary morphology 0.00151896860620326 0.0151440256830886 1.2388377037562 0.764705882352941 2.1 2 1 increased regulatory T cell number 0.00151896860620326 0.0151440256830886 1.2388377037562 0.764705882352941 2.1 2 1 pancytopenia 0.00151896860620326 0.0151440256830886 1.2388377037562 0.764705882352941 2.1 2 1 decreased T cell number 4.78310352026166e-23 1.39976117725304e-20 1.23765391235271 0.763975155279503 2.1 2 1 decreased T cell proliferation 2.97136755723914e-21 6.71934254421123e-19 1.23690604413496 0.763513513513513 2.1 2 1 decreased cell proliferation 5.03303070336318e-26 2.08661064576932e-23 1.23471682989755 0.762162162162162 2.1 2 1 abnormal spleen white pulp morphology 5.95198744935462e-07 1.60060203029942e-05 1.23429983670948 0.761904761904762 2.1 2 1 abnormal hematopoietic system physiology 0.000449319354940584 0.00544421782538656 1.23429983670948 0.761904761904762 2.1 2 1 abnormal embryo size 2.27795891175142e-16 2.6982965680865e-14 1.23293446078391 0.761061946902655 2.1 2 1 spontaneous skin ulceration 0.000134971365516782 0.00195198413792439 1.2312140871177 0.76 2.1 2 1 abnormal neural tube closure 2.81237763916113e-12 1.90072079140457e-10 1.22965262346885 0.759036144578313 2.1 2 1 abnormal CD8-positive, alpha-beta T cell physiology 4.09902357412539e-05 0.000692684897833455 1.22897957879262 0.758620689655172 2.1 2 1 embryonic lethality between somite formation and embryo turning, complete penetrance 1.78020042906815e-10 9.13040941712789e-09 1.22658546273004 0.757142857142857 2.1 2 1 preweaning lethality, complete penetrance 9.02545385074926e-98 4.49016329074776e-94 1.22595997294792 0.756756756756757 2.1 2 1 embryonic lethality, complete penetrance 2.43104000692045e-42 1.72777486206132e-39 1.22390115078108 0.755485893416928 2.1 2 1 decreased bone marrow cell number 1.12182664349099e-10 6.0663995123562e-09 1.22056191044473 0.753424657534247 2.1 2 1 embryonic growth arrest 4.41894742428611e-30 2.19842634358234e-27 1.21678248094831 0.751091703056769 2.1 2 1 decreased embryo size 2.22530520732659e-61 3.69029780214993e-58 1.21670848181913 0.751046025104602 2.1 2 1 enlarged spleen 2.98524102635748e-37 1.65017490068094e-34 1.21501390176089 0.75 2.1 2 1 increased T cell number 2.23279485861163e-12 1.54279922522123e-10 1.21501390176089 0.75 2.1 2 1 liver hypoplasia 7.23869609096883e-08 2.30694304344625e-06 1.21501390176089 0.75 2.1 2 1 vertebral transformation 2.3156280957355e-07 6.43589372976765e-06 1.21501390176089 0.75 2.1 2 1 thymus atrophy 2.3156280957355e-07 6.43589372976765e-06 1.21501390176089 0.75 2.1 2 1 abnormal lysosome morphology 7.7356875952482e-06 0.000161701873051932 1.21501390176089 0.75 2.1 2 1 failure of primitive streak formation 2.51496030318133e-05 0.000440560827757997 1.21501390176089 0.75 2.1 2 1 abnormal spongiotrophoblast layer morphology 2.51496030318133e-05 0.000440560827757997 1.21501390176089 0.75 2.1 2 1 premature aging 8.23208197388061e-05 0.00126403110555728 1.21501390176089 0.75 2.1 2 1 small lymph nodes 0.000271849940218008 0.00354974659471021 1.21501390176089 0.75 2.1 2 1 abnormal bone marrow cell number 0.00308866993097956 0.0269637873826524 1.21501390176089 0.75 2.1 2 1 mixed cellular infiltration to dermis 0.00308866993097956 0.0269637873826524 1.21501390176089 0.75 2.1 2 1 disorganized retinal layers 0.00308866993097956 0.0269637873826524 1.21501390176089 0.75 2.1 2 1 abnormal meiosis 0.00308866993097956 0.0269637873826524 1.21501390176089 0.75 2.1 2 1 blepharitis 0.00308866993097956 0.0269637873826524 1.21501390176089 0.75 2.1 2 1 decreased fibroblast apoptosis 0.00308866993097956 0.0269637873826524 1.21501390176089 0.75 2.1 2 1 abnormal adipose tissue distribution 0.0107789093059635 0.0734590052016007 1.21501390176089 0.75 2.1 2 1 absent optic nerve 0.0107789093059635 0.0734590052016007 1.21501390176089 0.75 2.1 2 1 abnormal thymus involution 0.0107789093059635 0.0734590052016007 1.21501390176089 0.75 2.1 2 1 myocarditis 0.0107789093059635 0.0734590052016007 1.21501390176089 0.75 2.1 2 1 abnormal embryonic growth/weight/body size 0.0107789093059635 0.0734590052016007 1.21501390176089 0.75 2.1 2 1 small intestinal inflammation 0.0107789093059635 0.0734590052016007 1.21501390176089 0.75 2.1 2 1 abnormal vascular endothelial cell development 0.0107789093059635 0.0734590052016007 1.21501390176089 0.75 2.1 2 1 abnormal B cell proliferation 0.0107789093059635 0.0734590052016007 1.21501390176089 0.75 2.1 2 1 decreased red blood cell distribution width 0.0107789093059635 0.0734590052016007 1.21501390176089 0.75 2.1 2 1 abnormal pulmonary valve cusp morphology 0.0107789093059635 0.0734590052016007 1.21501390176089 0.75 2.1 2 1 embryonic lethality between implantation and placentation, incomplete penetrance 0.0107789093059635 0.0734590052016007 1.21501390176089 0.75 2.1 2 1 abnormal bone marrow development 0.0393643690608112 0.188735388964753 1.21501390176089 0.75 2.1 2 1 schistocytosis 0.0393643690608112 0.188735388964753 1.21501390176089 0.75 2.1 2 1 abnormal cecum morphology 0.0393643690608112 0.188735388964753 1.21501390176089 0.75 2.1 2 1 enlarged pituitary gland 0.0393643690608112 0.188735388964753 1.21501390176089 0.75 2.1 2 1 abnormal vagus ganglion morphology 0.0393643690608112 0.188735388964753 1.21501390176089 0.75 2.1 2 1 dry eyes 0.0393643690608112 0.188735388964753 1.21501390176089 0.75 2.1 2 1 abnormal erythrocyte cell number 0.0393643690608112 0.188735388964753 1.21501390176089 0.75 2.1 2 1 abnormal atrial thrombosis 0.0393643690608112 0.188735388964753 1.21501390176089 0.75 2.1 2 1 hypospadia 0.0393643690608112 0.188735388964753 1.21501390176089 0.75 2.1 2 1 binucleate 0.0393643690608112 0.188735388964753 1.21501390176089 0.75 2.1 2 1 lymph node inflammation 0.0393643690608112 0.188735388964753 1.21501390176089 0.75 2.1 2 1 tau protein deposits 0.0393643690608112 0.188735388964753 1.21501390176089 0.75 2.1 2 1 abnormal extraembryonic tissue physiology 0.0393643690608112 0.188735388964753 1.21501390176089 0.75 2.1 2 1 absent interparietal bone 0.0393643690608112 0.188735388964753 1.21501390176089 0.75 2.1 2 1 abnormal kidney epithelium morphology 0.0393643690608112 0.188735388964753 1.21501390176089 0.75 2.1 2 1 abnormal somite size 0.0393643690608112 0.188735388964753 1.21501390176089 0.75 2.1 2 1 abnormal vertebral body development 0.0393643690608112 0.188735388964753 1.21501390176089 0.75 2.1 2 1 craniofacial phenotype 0.0393643690608112 0.188735388964753 1.21501390176089 0.75 2.1 2 1 decreased hippocampus pyramidal cell number 0.0393643690608112 0.188735388964753 1.21501390176089 0.75 2.1 2 1 abnormal cerebellum deep nucleus morphology 0.0393643690608112 0.188735388964753 1.21501390176089 0.75 2.1 2 1 decreased quadriceps weight 0.0393643690608112 0.188735388964753 1.21501390176089 0.75 2.1 2 1 ostium secundum atrial septal defect 0.0393643690608112 0.188735388964753 1.21501390176089 0.75 2.1 2 1 abnormal hepatic vein morphology 0.0393643690608112 0.188735388964753 1.21501390176089 0.75 2.1 2 1 myocardial trabeculae hypoplasia 0.0393643690608112 0.188735388964753 1.21501390176089 0.75 2.1 2 1 increased heart right ventricle size 0.0393643690608112 0.188735388964753 1.21501390176089 0.75 2.1 2 1 delayed suture closure 0.0393643690608112 0.188735388964753 1.21501390176089 0.75 2.1 2 1 abnormal branching involved in ureteric bud morphogenesis 0.0393643690608112 0.188735388964753 1.21501390176089 0.75 2.1 2 1 decreased cranium length 0.0393643690608112 0.188735388964753 1.21501390176089 0.75 2.1 2 1 abnormal umbilical vein topology 0.0393643690608112 0.188735388964753 1.21501390176089 0.75 2.1 2 1 embryo cyst 0.0393643690608112 0.188735388964753 1.21501390176089 0.75 2.1 2 1 increased mammary gland apoptosis 0.0393643690608112 0.188735388964753 1.21501390176089 0.75 2.1 2 1 decreased vascular endothelial cell proliferation 0.0393643690608112 0.188735388964753 1.21501390176089 0.75 2.1 2 1 decreased circulating total protein level 4.48982313639771e-08 1.51951497303256e-06 1.20765018114416 0.745454545454545 2.1 2 1 increased lung adenocarcinoma incidence 1.43311123486974e-07 4.16943180905085e-06 1.20707263442912 0.745098039215686 2.1 2 1 embryonic lethality before implantation, complete penetrance 1.79369942574129e-16 2.23091366076573e-14 1.2052937905468 0.744 2.1 2 1 increased autoantibody level 4.74207779456211e-06 0.000105792991156711 1.20462916755781 0.743589743589744 2.1 2 1 pale liver 2.74156727003377e-10 1.37770678468869e-08 1.20406783057385 0.743243243243243 2.1 2 1 holoprosencephaly 1.53445797107978e-05 0.000292487678395476 1.20344234079174 0.742857142857143 2.1 2 1 osteopetrosis 4.99273844742125e-05 0.000825211753352848 1.20194923615056 0.741935483870968 2.1 2 1 autoimmune response 4.99273844742125e-05 0.000825211753352848 1.20194923615056 0.741935483870968 2.1 2 1 increased lung adenoma incidence 4.99273844742125e-05 0.000825211753352848 1.20194923615056 0.741935483870968 2.1 2 1 abnormal mitochondrial ATP synthesis coupled electron transport 4.99273844742125e-05 0.000825211753352848 1.20194923615056 0.741935483870968 2.1 2 1 abnormal Wolffian duct morphology 0.000540981311479216 0.00626928464377208 1.19740500463392 0.739130434782609 2.1 2 1 decreased effector memory CD8-positive, alpha-beta T cell number 0.000540981311479216 0.00626928464377208 1.19740500463392 0.739130434782609 2.1 2 1 abnormal blastocyst morphology 0.00181137736849145 0.0175323004051459 1.19369786839666 0.736842105263158 2.1 2 1 Leydig cell hypoplasia 0.00181137736849145 0.0175323004051459 1.19369786839666 0.736842105263158 2.1 2 1 embryonic lethality between implantation and somite formation, incomplete penetrance 0.00181137736849145 0.0175323004051459 1.19369786839666 0.736842105263158 2.1 2 1 macrocytosis 0.00617432150324407 0.0483663561503906 1.18801359283287 0.733333333333333 2.1 2 1 decreased hepatocyte number 0.00617432150324407 0.0483663561503906 1.18801359283287 0.733333333333333 2.1 2 1 increased airway responsiveness 0.00617432150324407 0.0483663561503906 1.18801359283287 0.733333333333333 2.1 2 1 heterochrony 0.00617432150324407 0.0483663561503906 1.18801359283287 0.733333333333333 2.1 2 1 decreased B cell number 1.06678675518183e-24 3.31704006689349e-22 1.18748931498961 0.733009708737864 2.1 2 1 abnormal cell differentiation 5.65018026288395e-06 0.000122749549379247 1.18537941635209 0.731707317073171 2.1 2 1 increased leukemia incidence 0.000321432825703856 0.00405870128902711 1.18385969915164 0.730769230769231 2.1 2 1 abnormal lymph node morphology 1.06987033956566e-06 2.71286072666793e-05 1.18126351560087 0.729166666666667 2.1 2 1 increased B cell proliferation 6.44155811056889e-08 2.09455892810982e-06 1.18069147515747 0.728813559322034 2.1 2 1 abnormal vascular development 1.24178813847464e-08 4.71595113657355e-07 1.17819529867723 0.727272727272727 2.1 2 1 abnormal rostral-caudal axis patterning 2.04212065478192e-07 5.739858902565e-06 1.17819529867723 0.727272727272727 2.1 2 1 decreased brown adipose tissue amount 5.87468151060368e-05 0.000948913653092641 1.17819529867723 0.727272727272727 2.1 2 1 myeloid hyperplasia 5.87468151060368e-05 0.000948913653092641 1.17819529867723 0.727272727272727 2.1 2 1 intestinal inflammation 0.00106245478641549 0.0112461969413129 1.17819529867723 0.727272727272727 2.1 2 1 abnormal lysosome physiology 0.00106245478641549 0.0112461969413129 1.17819529867723 0.727272727272727 2.1 2 1 abnormal occipital bone morphology 0.00106245478641549 0.0112461969413129 1.17819529867723 0.727272727272727 2.1 2 1 impaired humoral immune response 0.00106245478641549 0.0112461969413129 1.17819529867723 0.727272727272727 2.1 2 1 abnormal sphenoid bone morphology 0.0216354875035477 0.121760803540894 1.17819529867723 0.727272727272727 2.1 2 1 abnormal eye distance/ position 0.0216354875035477 0.121760803540894 1.17819529867723 0.727272727272727 2.1 2 1 abnormal hemoglobin 0.0216354875035477 0.121760803540894 1.17819529867723 0.727272727272727 2.1 2 1 vasculitis 0.0216354875035477 0.121760803540894 1.17819529867723 0.727272727272727 2.1 2 1 aorta dilation 0.0216354875035477 0.121760803540894 1.17819529867723 0.727272727272727 2.1 2 1 abnormal dendritic cell chemotaxis 0.0216354875035477 0.121760803540894 1.17819529867723 0.727272727272727 2.1 2 1 decreased core body temperature 0.0216354875035477 0.121760803540894 1.17819529867723 0.727272727272727 2.1 2 1 decreased embryonic cilium length 0.0216354875035477 0.121760803540894 1.17819529867723 0.727272727272727 2.1 2 1 chylous ascites 0.0216354875035477 0.121760803540894 1.17819529867723 0.727272727272727 2.1 2 1 thin hypoglossal nerve 0.0216354875035477 0.121760803540894 1.17819529867723 0.727272727272727 2.1 2 1 embryonic lethality during organogenesis, complete penetrance 1.23020702591415e-62 3.06013997696145e-59 1.17740632861115 0.726785714285714 2.1 2 1 abnormal spleen morphology 4.25379923421714e-20 8.46506047609211e-18 1.17311687066569 0.724137931034483 2.1 2 1 decreased granulocyte number 0.00019081360273238 0.00260081554409203 1.17311687066569 0.724137931034483 2.1 2 1 pale yolk sac 2.84713260907474e-10 1.41644847301468e-08 1.171097736637 0.72289156626506 2.1 2 1 abnormal megakaryocyte differentiation 0.00355510366819167 0.0302853437487219 1.17001338688086 0.722222222222222 2.1 2 1 abnormal bile duct morphology 0.00355510366819167 0.0302853437487219 1.17001338688086 0.722222222222222 2.1 2 1 abnormal neutrophil morphology 0.00355510366819167 0.0302853437487219 1.17001338688086 0.722222222222222 2.1 2 1 impaired leukocyte tethering or rolling 0.00355510366819167 0.0302853437487219 1.17001338688086 0.722222222222222 2.1 2 1 decreased IgM level 1.08193952893416e-11 6.90083225185567e-10 1.16908554121323 0.721649484536082 2.1 2 1 abnormal left-right axis patterning 6.57153634681197e-06 0.000140919798816334 1.16792033967713 0.720930232558139 2.1 2 1 abnormal embryo development 1.00311383331992e-15 1.0618066639929e-13 1.16736629777027 0.720588235294118 2.1 2 1 decreased oocyte number 1.24323117151605e-06 3.09253753914617e-05 1.16641334569045 0.72 2.1 2 1 abnormal preimplantation embryo development 0.000623823418021163 0.00710187987335306 1.16641334569045 0.72 2.1 2 1 incomplete embryo turning 2.37137852708362e-07 6.55422676235612e-06 1.1652764905777 0.719298245614035 2.1 2 1 abnormal ovary morphology 8.77805666257631e-09 3.49366655170537e-07 1.16367528619353 0.71830985915493 2.1 2 1 increased B cell number 1.54071931286445e-13 1.36876403241083e-11 1.16309023074547 0.717948717948718 2.1 2 1 abnormal leukocyte adhesion 2.09901354426789e-05 0.000379730632099373 1.16309023074547 0.717948717948718 2.1 2 1 increased hepatocyte apoptosis 2.09901354426789e-05 0.000379730632099373 1.16309023074547 0.717948717948718 2.1 2 1 intracranial hemorrhage 1.43190849828326e-07 4.16943180905085e-06 1.16101328390485 0.716666666666667 2.1 2 1 abnormal liver development 6.7223410999975e-05 0.00105834325862302 1.15715609691513 0.714285714285714 2.1 2 1 abnormal embryonic epiblast morphology 6.7223410999975e-05 0.00105834325862302 1.15715609691513 0.714285714285714 2.1 2 1 increased red blood cell distribution width 6.7223410999975e-05 0.00105834325862302 1.15715609691513 0.714285714285714 2.1 2 1 abnormal eye pigmentation 0.00205661314085984 0.0196008627888462 1.15715609691513 0.714285714285714 2.1 2 1 rib bifurcation 0.000366778691981241 0.00456180998151669 1.15715609691513 0.714285714285714 2.1 2 1 abnormal spleen germinal center morphology 0.000366778691981241 0.00456180998151669 1.15715609691513 0.714285714285714 2.1 2 1 abnormal brainstem morphology 0.000366778691981241 0.00456180998151669 1.15715609691513 0.714285714285714 2.1 2 1 abnormal antigen presentation 0.012104887540257 0.0806182269247369 1.15715609691513 0.714285714285714 2.1 2 1 failure of zygotic cell division 0.012104887540257 0.0806182269247369 1.15715609691513 0.714285714285714 2.1 2 1 absent olfactory bulb 0.012104887540257 0.0806182269247369 1.15715609691513 0.714285714285714 2.1 2 1 lysosomal protein accumulation 0.012104887540257 0.0806182269247369 1.15715609691513 0.714285714285714 2.1 2 1 abnormal viscerocranium morphology 0.012104887540257 0.0806182269247369 1.15715609691513 0.714285714285714 2.1 2 1 multiple persisting craniopharyngeal ducts 0.012104887540257 0.0806182269247369 1.15715609691513 0.714285714285714 2.1 2 1 asymmetric rib joints 0.0795717003541435 0.293996796249452 1.15715609691513 0.714285714285714 2.1 2 1 cellular necrosis 0.0795717003541435 0.293996796249452 1.15715609691513 0.714285714285714 2.1 2 1 broad head 0.0795717003541435 0.293996796249452 1.15715609691513 0.714285714285714 2.1 2 1 polyphalangy 0.0795717003541435 0.293996796249452 1.15715609691513 0.714285714285714 2.1 2 1 prostate gland epithelial hyperplasia 0.0795717003541435 0.293996796249452 1.15715609691513 0.714285714285714 2.1 2 1 skin photosensitivity 0.0795717003541435 0.293996796249452 1.15715609691513 0.714285714285714 2.1 2 1 abnormal lacrimal gland morphology 0.0795717003541435 0.293996796249452 1.15715609691513 0.714285714285714 2.1 2 1 abnormal axial mesoderm 0.0795717003541435 0.293996796249452 1.15715609691513 0.714285714285714 2.1 2 1 abnormal hypersensitivity reaction 0.0795717003541435 0.293996796249452 1.15715609691513 0.714285714285714 2.1 2 1 abnormal brain ventricular system morphology 0.0795717003541435 0.293996796249452 1.15715609691513 0.714285714285714 2.1 2 1 abnormal lymph node primary follicle morphology 0.0795717003541435 0.293996796249452 1.15715609691513 0.714285714285714 2.1 2 1 abnormal melanocyte morphology 0.0795717003541435 0.293996796249452 1.15715609691513 0.714285714285714 2.1 2 1 detached tectorial membrane 0.0795717003541435 0.293996796249452 1.15715609691513 0.714285714285714 2.1 2 1 increased ectoderm apoptosis 0.0795717003541435 0.293996796249452 1.15715609691513 0.714285714285714 2.1 2 1 abnormal optic tract morphology 0.0795717003541435 0.293996796249452 1.15715609691513 0.714285714285714 2.1 2 1 abnormal cochlear nerve compound action potential 0.0795717003541435 0.293996796249452 1.15715609691513 0.714285714285714 2.1 2 1 decreased adrenocorticotropin level 0.0795717003541435 0.293996796249452 1.15715609691513 0.714285714285714 2.1 2 1 decreased tidal volume 0.0795717003541435 0.293996796249452 1.15715609691513 0.714285714285714 2.1 2 1 abnormal uterus physiology 0.0795717003541435 0.293996796249452 1.15715609691513 0.714285714285714 2.1 2 1 abnormal spinal cord central canal morphology 0.0795717003541435 0.293996796249452 1.15715609691513 0.714285714285714 2.1 2 1 decreased brain cholesterol level 0.0795717003541435 0.293996796249452 1.15715609691513 0.714285714285714 2.1 2 1 coronary fistula 0.0795717003541435 0.293996796249452 1.15715609691513 0.714285714285714 2.1 2 1 altered tumor pathology 0.0795717003541435 0.293996796249452 1.15715609691513 0.714285714285714 2.1 2 1 increased compact bone volume 0.0795717003541435 0.293996796249452 1.15715609691513 0.714285714285714 2.1 2 1 abnormal outer hair cell kinocilium morphology 0.0795717003541435 0.293996796249452 1.15715609691513 0.714285714285714 2.1 2 1 increased circulating lactate dehydrogenase level 0.0795717003541435 0.293996796249452 1.15715609691513 0.714285714285714 2.1 2 1 small tail bud 0.0795717003541435 0.293996796249452 1.15715609691513 0.714285714285714 2.1 2 1 absent heart tube 0.0795717003541435 0.293996796249452 1.15715609691513 0.714285714285714 2.1 2 1 decreased areal bone mineral density 0.0795717003541435 0.293996796249452 1.15715609691513 0.714285714285714 2.1 2 1 abnormal Mullerian duct topology 0.0795717003541435 0.293996796249452 1.15715609691513 0.714285714285714 2.1 2 1 astrocytosis 1.005600277204e-08 3.90848545241399e-07 1.15398580623865 0.712328767123288 2.1 2 1 decreased IgG level 1.70720806400605e-12 1.23092175629422e-10 1.15298616503436 0.711711711711712 2.1 2 1 increased monocyte cell number 2.70627168701501e-11 1.60282162415472e-09 1.15021316033364 0.71 2.1 2 1 decreased thymus weight 0.000215960074554723 0.00289596056848989 1.14969057370923 0.709677419354839 2.1 2 1 decreased double-negative T cell number 0.000215960074554723 0.00289596056848989 1.14969057370923 0.709677419354839 2.1 2 1 preaxial polydactyly 0.000215960074554723 0.00289596056848989 1.14969057370923 0.709677419354839 2.1 2 1 hemolytic anemia 0.00119458607025644 0.0122034203275683 1.14751312944084 0.708333333333333 2.1 2 1 abnormal tumor morphology 0.00119458607025644 0.0122034203275683 1.14751312944084 0.708333333333333 2.1 2 1 abnormal cellular extravasation 0.00119458607025644 0.0122034203275683 1.14751312944084 0.708333333333333 2.1 2 1 abnormal inner cell mass apoptosis 0.00119458607025644 0.0122034203275683 1.14751312944084 0.708333333333333 2.1 2 1 decreased circulating serum albumin level 5.06944889499761e-11 2.93261723867594e-09 1.14546765149175 0.707070707070707 2.1 2 1 enlarged liver sinusoidal spaces 0.00012733812431346 0.00185779228287233 1.14354249577496 0.705882352941177 2.1 2 1 abnormal oocyte morphology 0.00012733812431346 0.00185779228287233 1.14354249577496 0.705882352941177 2.1 2 1 increased brain size 0.00685595311044267 0.0524744103453112 1.14354249577496 0.705882352941177 2.1 2 1 abnormal trophoblast layer morphology 2.67089365626579e-06 6.20920371024407e-05 1.14354249577495 0.705882352941177 2.1 2 1 increased inflammatory response 1.56740519784146e-10 8.20825353606447e-09 1.14253938832252 0.705263157894737 2.1 2 1 spleen hypoplasia 1.8504194383305e-11 1.12266301288954e-09 1.14172734895626 0.704761904761905 2.1 2 1 abnormal myelopoiesis 1.40958281046432e-05 0.000275006842433726 1.14137669559356 0.704545454545455 2.1 2 1 abnormal fetal cardiomyocyte proliferation 0.000696298855134912 0.00787292455521861 1.1400130436275 0.703703703703704 2.1 2 1 decreased lymphocyte cell number 1.57152979223912e-13 1.37164223094554e-11 1.13907553290083 0.703125 2.1 2 1 abnormal osteoclast physiology 1.83219695689094e-07 5.20867420601852e-06 1.13907553290083 0.703125 2.1 2 1 impaired natural killer cell mediated cytotoxicity 9.53213360165072e-07 2.44445178702125e-05 1.13685511275873 0.701754385964912 2.1 2 1 salivary gland inflammation 0.000407074354204962 0.00501285869348932 1.13401297497683 0.7 2.1 2 1 abnormal optic cup morphology 0.000407074354204962 0.00501285869348932 1.13401297497683 0.7 2.1 2 1 abnormal brain vasculature morphology 0.000407074354204962 0.00501285869348932 1.13401297497683 0.7 2.1 2 1 abnormal Peyer's patch T cell area morphology 0.00391798354283066 0.0330372341111569 1.13401297497683 0.7 2.1 2 1 decreased myocardial infarction size 0.00391798354283066 0.0330372341111569 1.13401297497683 0.7 2.1 2 1 retarded hair growth 0.0423268285641473 0.197036986330999 1.13401297497683 0.7 2.1 2 1 kidney hemorrhage 0.0423268285641473 0.197036986330999 1.13401297497683 0.7 2.1 2 1 enlarged testis 0.0423268285641473 0.197036986330999 1.13401297497683 0.7 2.1 2 1 absent trophoblast giant cells 0.0423268285641473 0.197036986330999 1.13401297497683 0.7 2.1 2 1 acrania 0.0423268285641473 0.197036986330999 1.13401297497683 0.7 2.1 2 1 abnormal submandibular gland morphology 0.0423268285641473 0.197036986330999 1.13401297497683 0.7 2.1 2 1 abnormal gas homeostasis 0.0423268285641473 0.197036986330999 1.13401297497683 0.7 2.1 2 1 increased platelet aggregation 0.0423268285641473 0.197036986330999 1.13401297497683 0.7 2.1 2 1 absent inguinal lymph nodes 0.0423268285641473 0.197036986330999 1.13401297497683 0.7 2.1 2 1 protruding tongue 0.0423268285641473 0.197036986330999 1.13401297497683 0.7 2.1 2 1 thin ventricle myocardium compact layer 0.0423268285641473 0.197036986330999 1.13401297497683 0.7 2.1 2 1 decreased trabecular bone connectivity density 0.0423268285641473 0.197036986330999 1.13401297497683 0.7 2.1 2 1 abnormal adaptive thermogenesis 0.0423268285641473 0.197036986330999 1.13401297497683 0.7 2.1 2 1 increased fatty acid oxidation 0.0423268285641473 0.197036986330999 1.13401297497683 0.7 2.1 2 1 abnormal neural tube morphology 3.30855648343867e-16 3.74092466025167e-14 1.13001292920972 0.697530864197531 2.1 2 1 pallor 2.38153452006336e-17 3.38518121066149e-15 1.12938435058917 0.697142857142857 2.1 2 1 abnormal ovarian folliculogenesis 0.000238601984185248 0.00314866013613159 1.12910382789901 0.696969696969697 2.1 2 1 decreased rib number 1.66072638205558e-09 7.24746820239168e-08 1.1285522383397 0.696629213483146 2.1 2 1 thrombocytopenia 1.40518451134024e-14 1.37074371449367e-12 1.12842670416414 0.696551724137931 2.1 2 1 abnormal placenta labyrinth morphology 1.41730295366064e-08 5.30156555974562e-07 1.12786100585399 0.69620253164557 2.1 2 1 abnormal spermatogenesis 5.22955271308341e-18 8.39258862825483e-16 1.12696941612604 0.695652173913043 2.1 2 1 increased lymphocyte cell number 1.217183217503e-07 3.66999182247116e-06 1.12696941612604 0.695652173913043 2.1 2 1 abnormal immune system morphology 1.55859622207425e-05 0.000293712735031038 1.12696941612604 0.695652173913043 2.1 2 1 abnormal vertebral artery topology 0.0022543941576984 0.0214038376613541 1.12696941612604 0.695652173913043 2.1 2 1 hydrops fetalis 7.2802021672575e-08 2.30694304344625e-06 1.12501287200082 0.694444444444444 2.1 2 1 decreased erythrocyte cell number 1.85491850553284e-15 1.92254574271373e-13 1.12472624451751 0.694267515923567 2.1 2 1 lethality throughout fetal growth and development, incomplete penetrance 2.91877251697758e-17 3.92456574917931e-15 1.12224747723166 0.692737430167598 2.1 2 1 decreased IgA level 5.4869029049388e-06 0.000119725184000309 1.12155129393313 0.692307692307692 2.1 2 1 abnormal leukocyte migration 5.4869029049388e-06 0.000119725184000309 1.12155129393313 0.692307692307692 2.1 2 1 abnormal placenta vasculature 5.4869029049388e-06 0.000119725184000309 1.12155129393313 0.692307692307692 2.1 2 1 kinked neural tube 5.4869029049388e-06 0.000119725184000309 1.12155129393313 0.692307692307692 2.1 2 1 abnormal leukocyte cell number 0.0013042022507351 0.0132687243300759 1.12155129393313 0.692307692307692 2.1 2 1 short premaxilla 0.0232067332511811 0.127011548871976 1.12155129393313 0.692307692307692 2.1 2 1 abnormal mast cell morphology 0.0232067332511811 0.127011548871976 1.12155129393313 0.692307692307692 2.1 2 1 uterus hypoplasia 0.0232067332511811 0.127011548871976 1.12155129393313 0.692307692307692 2.1 2 1 abnormal grip strength 0.0232067332511811 0.127011548871976 1.12155129393313 0.692307692307692 2.1 2 1 lymphoid hypoplasia 0.0232067332511811 0.127011548871976 1.12155129393313 0.692307692307692 2.1 2 1 abnormal tail bud morphology 0.0232067332511811 0.127011548871976 1.12155129393313 0.692307692307692 2.1 2 1 abnormal coping response 0.0232067332511811 0.127011548871976 1.12155129393313 0.692307692307692 2.1 2 1 increased circulating thyroxine level 0.0232067332511811 0.127011548871976 1.12155129393313 0.692307692307692 2.1 2 1 orthokeratosis 0.0232067332511811 0.127011548871976 1.12155129393313 0.692307692307692 2.1 2 1 decreased circulating calcium level 3.25968748800746e-06 7.4389657123106e-05 1.11928553374337 0.690909090909091 2.1 2 1 abnormal reproductive system morphology 4.86471228742263e-05 0.000817633230740797 1.11858422701796 0.69047619047619 2.1 2 1 abnormal CD4-positive, alpha-beta T cell physiology 1.33594254106454e-07 3.9798288274228e-06 1.11804096124476 0.690140845070423 2.1 2 1 abnormal spermiogenesis 1.93799543650849e-06 4.61317095532524e-05 1.11725416253875 0.689655172413793 2.1 2 1 abnormal embryonic neuroepithelium morphology 1.93799543650849e-06 4.61317095532524e-05 1.11725416253875 0.689655172413793 2.1 2 1 lordosis 0.000757812223645373 0.00839669446021321 1.11725416253875 0.689655172413793 2.1 2 1 decreased trophoblast giant cell number 0.000757812223645373 0.00839669446021321 1.11725416253875 0.689655172413793 2.1 2 1 abnormal angiogenesis 7.97846662073638e-08 2.49640700868953e-06 1.11649926107757 0.689189189189189 2.1 2 1 small seminiferous tubules 7.97846662073638e-08 2.49640700868953e-06 1.11649926107757 0.689189189189189 2.1 2 1 abnormal ectoderm development 2.87277138300065e-05 0.00050147500457643 1.11601276902482 0.688888888888889 2.1 2 1 bradykinesia 0.000441925799289029 0.00542859469497017 1.11376274328082 0.6875 2.1 2 1 absent mandible 0.012962754962226 0.0851911571163467 1.11376274328082 0.6875 2.1 2 1 failure of tooth eruption 0.012962754962226 0.0851911571163467 1.11376274328082 0.6875 2.1 2 1 abnormal olfaction 0.012962754962226 0.0851911571163467 1.11376274328082 0.6875 2.1 2 1 white spotting 0.012962754962226 0.0851911571163467 1.11376274328082 0.6875 2.1 2 1 impaired somite development 0.012962754962226 0.0851911571163467 1.11376274328082 0.6875 2.1 2 1 decreased midbrain size 0.012962754962226 0.0851911571163467 1.11376274328082 0.6875 2.1 2 1 abnormal gastrulation 1.00577658997646e-05 0.000201763650610198 1.11177742644787 0.686274509803922 2.1 2 1 failure of chorioallantoic fusion 1.00577658997646e-05 0.000201763650610198 1.11177742644787 0.686274509803922 2.1 2 1 decreased leukocyte cell number 4.75696913745069e-13 3.69780022794019e-11 1.11154556462797 0.686131386861314 2.1 2 1 ovary cysts 0.000258497498815611 0.00338427646475702 1.11086985303853 0.685714285714286 2.1 2 1 abnormal midbrain development 0.000258497498815611 0.00338427646475702 1.11086985303853 0.685714285714286 2.1 2 1 abnormal fertility/fecundity 1.45316455915561e-07 4.20319400104603e-06 1.10960173676794 0.684931506849315 2.1 2 1 lethality throughout fetal growth and development, complete penetrance 2.51961526159551e-17 3.48196831289934e-15 1.10843373493976 0.684210526315789 2.1 2 1 increased bone marrow cell number 0.000151595413579204 0.00216720454757626 1.10843373493976 0.684210526315789 2.1 2 1 decreased neuron apoptosis 0.000151595413579204 0.00216720454757626 1.10843373493976 0.684210526315789 2.1 2 1 decreased total retina thickness 0.000151595413579204 0.00216720454757626 1.10843373493976 0.684210526315789 2.1 2 1 kyphoscoliosis 0.00733317731754214 0.0549436101728496 1.10843373493976 0.684210526315789 2.1 2 1 increased susceptibility to ischemic brain injury 0.00733317731754214 0.0549436101728496 1.10843373493976 0.684210526315789 2.1 2 1 increased liver adenoma incidence 0.00733317731754214 0.0549436101728496 1.10843373493976 0.684210526315789 2.1 2 1 abnormal optic vesicle formation 0.00733317731754214 0.0549436101728496 1.10843373493976 0.684210526315789 2.1 2 1 decreased susceptibility to weight gain 0.00733317731754214 0.0549436101728496 1.10843373493976 0.684210526315789 2.1 2 1 osteoporosis 5.24708310753285e-05 0.000858692054604471 1.1045580925099 0.681818181818182 2.1 2 1 omphalocele 5.24708310753285e-05 0.000858692054604471 1.1045580925099 0.681818181818182 2.1 2 1 abnormal oogenesis 0.00418695247181202 0.0347747721991065 1.1045580925099 0.681818181818182 2.1 2 1 testis hypoplasia 0.00418695247181202 0.0347747721991065 1.1045580925099 0.681818181818182 2.1 2 1 increased skin papilloma incidence 0.00418695247181202 0.0347747721991065 1.1045580925099 0.681818181818182 2.1 2 1 increased bone volume 0.00418695247181202 0.0347747721991065 1.1045580925099 0.681818181818182 2.1 2 1 abnormal embryonic tissue morphology 2.01433337411223e-13 1.69852687054379e-11 1.10205342563346 0.680272108843537 2.1 2 1 testicular atrophy 1.82856649086392e-05 0.000338182836135613 1.10161260426321 0.68 2.1 2 1 abnormal cochlear outer hair cell morphology 0.0024074567062564 0.0227701466038509 1.10161260426321 0.68 2.1 2 1 abnormal mesoderm development 1.0817046838352e-05 0.000216123726991169 1.10038994876458 0.679245283018868 2.1 2 1 abnormal somite shape 0.00139195253290378 0.0140181454477658 1.09929829206938 0.678571428571429 2.1 2 1 failure of blastocyst to hatch from the zona pellucida 0.00139195253290378 0.0140181454477658 1.09929829206938 0.678571428571429 2.1 2 1 abnormal seminiferous tubule morphology 3.616338137751e-13 2.85575908497003e-11 1.09850571940026 0.678082191780822 2.1 2 1 anemia 2.4861857702808e-18 4.12292473571567e-16 1.09792725403986 0.677725118483412 2.1 2 1 abnormal object recognition memory 0.000808414341470464 0.0089327194832213 1.0974319112679 0.67741935483871 2.1 2 1 abnormal extraembryonic tissue morphology 1.51343616576376e-09 6.66313710148203e-08 1.09589489178433 0.676470588235294 2.1 2 1 increased neutrophil cell number 6.47180382386184e-13 4.95341908057118e-11 1.09490907928797 0.675862068965517 2.1 2 1 increased erythroid progenitor cell number 0.000275551330379482 0.00357928947425046 1.0946071187035 0.675675675675676 2.1 2 1 abnormal respiratory electron transport chain 0.000275551330379482 0.00357928947425046 1.0946071187035 0.675675675675676 2.1 2 1 anophthalmia 2.12358687093905e-08 7.54631763065842e-07 1.09214732742552 0.674157303370786 2.1 2 1 abnormal head morphology 1.15146553202185e-05 0.000228228725968475 1.08983065127643 0.672727272727273 2.1 2 1 abnormal T-helper 2 physiology 1.15146553202185e-05 0.000228228725968475 1.08983065127643 0.672727272727273 2.1 2 1 prenatal lethality, complete penetrance 6.25613108264736e-23 1.63811853348266e-20 1.08972469846181 0.672661870503597 2.1 2 1 increased spleen weight 3.45885847722836e-10 1.68704126707952e-08 1.08956998859974 0.672566371681416 2.1 2 1 dermatitis 6.81857911679814e-06 0.000145589833073265 1.08932280847528 0.672413793103448 2.1 2 1 abnormal placenta morphology 1.78515036428599e-07 5.10409371397862e-06 1.08684787836839 0.670886075949367 2.1 2 1 increased grip strength 2.2574395756488e-08 7.96507935379631e-07 1.08594649095112 0.67032967032967 2.1 2 1 small testis 1.97297925379064e-22 4.90778589380422e-20 1.08588198949645 0.670289855072464 2.1 2 1 decreased birth body size 6.49745625745489e-10 2.99304119267019e-08 1.08001235712079 0.666666666666667 2.1 2 1 microcephaly 1.50414201332572e-06 3.70450817638388e-05 1.08001235712079 0.666666666666667 2.1 2 1 absent mesoderm 7.19462699915576e-06 0.000152962689405128 1.08001235712079 0.666666666666667 2.1 2 1 decreased brain weight 1.21459293335846e-05 0.000239785708073744 1.08001235712079 0.666666666666667 2.1 2 1 increased cell proliferation 2.05285138670483e-05 0.000374231726703141 1.08001235712079 0.666666666666667 2.1 2 1 spina bifida 0.000170008470121988 0.00238251306720251 1.08001235712079 0.666666666666667 2.1 2 1 abnormal pharyngeal arch morphology 0.000495156075407118 0.00592163816141925 1.08001235712079 0.666666666666667 2.1 2 1 increased osteoblast cell number 0.000848573429496591 0.0092900786243968 1.08001235712079 0.666666666666667 2.1 2 1 abnormal eye muscle morphology 0.00252000904193547 0.0233030575903884 1.08001235712079 0.666666666666667 2.1 2 1 ocular hypertelorism 0.00437401033258233 0.0360873986809239 1.08001235712079 0.666666666666667 2.1 2 1 abnormal nursing 0.00437401033258233 0.0360873986809239 1.08001235712079 0.666666666666667 2.1 2 1 blindness 0.00437401033258233 0.0360873986809239 1.08001235712079 0.666666666666667 2.1 2 1 increased body temperature 0.00437401033258233 0.0360873986809239 1.08001235712079 0.666666666666667 2.1 2 1 abnormal salivary gland morphology 0.0076407243467723 0.0562316621674441 1.08001235712079 0.666666666666667 2.1 2 1 liver degeneration 0.0076407243467723 0.0562316621674441 1.08001235712079 0.666666666666667 2.1 2 1 left pulmonary isomerism 0.0076407243467723 0.0562316621674441 1.08001235712079 0.666666666666667 2.1 2 1 abnormal erythrocyte physiology 0.0076407243467723 0.0562316621674441 1.08001235712079 0.666666666666667 2.1 2 1 embryonic lethality at implantation, complete penetrance 0.0076407243467723 0.0562316621674441 1.08001235712079 0.666666666666667 2.1 2 1 absent segment of posterior cerebral artery 0.0076407243467723 0.0562316621674441 1.08001235712079 0.666666666666667 2.1 2 1 increased muscle cell glucose uptake 0.0076407243467723 0.0562316621674441 1.08001235712079 0.666666666666667 2.1 2 1 abnormal mammary gland morphology 0.0134576519949447 0.0873966688210078 1.08001235712079 0.666666666666667 2.1 2 1 abnormal Peyer's patch follicle morphology 0.0134576519949447 0.0873966688210078 1.08001235712079 0.666666666666667 2.1 2 1 long tibia 0.0134576519949447 0.0873966688210078 1.08001235712079 0.666666666666667 2.1 2 1 darkened coat color 0.0134576519949447 0.0873966688210078 1.08001235712079 0.666666666666667 2.1 2 1 primary atelectasis 0.0134576519949447 0.0873966688210078 1.08001235712079 0.666666666666667 2.1 2 1 abnormal fontanelle morphology 0.0239660196142827 0.129458140696044 1.08001235712079 0.666666666666667 2.1 2 1 abnormal prostate gland morphology 0.0239660196142827 0.129458140696044 1.08001235712079 0.666666666666667 2.1 2 1 abnormal trophectoderm morphology 0.0239660196142827 0.129458140696044 1.08001235712079 0.666666666666667 2.1 2 1 decreased brown adipose tissue mass 0.0239660196142827 0.129458140696044 1.08001235712079 0.666666666666667 2.1 2 1 abnormal mating frequency 0.0433486438987162 0.198034438380269 1.08001235712079 0.666666666666667 2.1 2 1 altered tumor susceptibility 0.0433486438987162 0.198034438380269 1.08001235712079 0.666666666666667 2.1 2 1 abnormal respiratory function 0.0433486438987162 0.198034438380269 1.08001235712079 0.666666666666667 2.1 2 1 increased growth rate 0.0433486438987162 0.198034438380269 1.08001235712079 0.666666666666667 2.1 2 1 abnormal gastrocnemius morphology 0.0433486438987162 0.198034438380269 1.08001235712079 0.666666666666667 2.1 2 1 loss of dopaminergic neurons 0.0433486438987162 0.198034438380269 1.08001235712079 0.666666666666667 2.1 2 1 abnormal defecation 0.0433486438987162 0.198034438380269 1.08001235712079 0.666666666666667 2.1 2 1 increased hepatocyte proliferation 0.0433486438987162 0.198034438380269 1.08001235712079 0.666666666666667 2.1 2 1 pale placenta 0.0433486438987162 0.198034438380269 1.08001235712079 0.666666666666667 2.1 2 1 decreased cochlear nerve compound action potential 0.0433486438987162 0.198034438380269 1.08001235712079 0.666666666666667 2.1 2 1 abnormal thymus corticomedullary boundary morphology 0.0433486438987162 0.198034438380269 1.08001235712079 0.666666666666667 2.1 2 1 decreased mammary gland epithelial cell proliferation 0.0433486438987162 0.198034438380269 1.08001235712079 0.666666666666667 2.1 2 1 increased skeletal muscle glycogen level 0.0433486438987162 0.198034438380269 1.08001235712079 0.666666666666667 2.1 2 1 persistent right dorsal aorta 0.0433486438987162 0.198034438380269 1.08001235712079 0.666666666666667 2.1 2 1 abnormal urinary bladder urothelium morphology 0.0802814181569781 0.293996796249452 1.08001235712079 0.666666666666667 2.1 2 1 abnormal vomeronasal organ morphology 0.0802814181569781 0.293996796249452 1.08001235712079 0.666666666666667 2.1 2 1 abnormal thymus lobule morphology 0.0802814181569781 0.293996796249452 1.08001235712079 0.666666666666667 2.1 2 1 priapism 0.0802814181569781 0.293996796249452 1.08001235712079 0.666666666666667 2.1 2 1 decreased fear-related response 0.0802814181569781 0.293996796249452 1.08001235712079 0.666666666666667 2.1 2 1 abnormal thymus physiology 0.0802814181569781 0.293996796249452 1.08001235712079 0.666666666666667 2.1 2 1 abnormal inguinal fat pad morphology 0.0802814181569781 0.293996796249452 1.08001235712079 0.666666666666667 2.1 2 1 decreased susceptibility to atherosclerosis 0.0802814181569781 0.293996796249452 1.08001235712079 0.666666666666667 2.1 2 1 absent cervical lymph nodes 0.0802814181569781 0.293996796249452 1.08001235712079 0.666666666666667 2.1 2 1 abnormal optic chiasm morphology 0.0802814181569781 0.293996796249452 1.08001235712079 0.666666666666667 2.1 2 1 abnormal liver vasculature morphology 0.0802814181569781 0.293996796249452 1.08001235712079 0.666666666666667 2.1 2 1 eye opacity 0.0802814181569781 0.293996796249452 1.08001235712079 0.666666666666667 2.1 2 1 decreased transitional stage T1 B cell number 0.0802814181569781 0.293996796249452 1.08001235712079 0.666666666666667 2.1 2 1 axonal spheroids 0.0802814181569781 0.293996796249452 1.08001235712079 0.666666666666667 2.1 2 1 decreased effector memory CD4-positive, alpha-beta T cell number 0.0802814181569781 0.293996796249452 1.08001235712079 0.666666666666667 2.1 2 1 increased core body temperature 0.0802814181569781 0.293996796249452 1.08001235712079 0.666666666666667 2.1 2 1 trigeminal neuroma 0.0802814181569781 0.293996796249452 1.08001235712079 0.666666666666667 2.1 2 1 abnormal ductus venosus valve topology 0.0802814181569781 0.293996796249452 1.08001235712079 0.666666666666667 2.1 2 1 abnormal infrahyoid muscle connection 0.0802814181569781 0.293996796249452 1.08001235712079 0.666666666666667 2.1 2 1 decreased fatty acid oxidation 0.0802814181569781 0.293996796249452 1.08001235712079 0.666666666666667 2.1 2 1 increased bone mineralization 0.0802814181569781 0.293996796249452 1.08001235712079 0.666666666666667 2.1 2 1 enhanced leukocyte tethering or rolling 0.0802814181569781 0.293996796249452 1.08001235712079 0.666666666666667 2.1 2 1 increased endoplasmic reticulum stress 0.0802814181569781 0.293996796249452 1.08001235712079 0.666666666666667 2.1 2 1 abnormal hepatocyte morphology 1.08628637889652e-09 4.91297703182745e-08 1.08001235712079 0.666666666666667 2.1 2 1 failure of heart looping 0.000289777117588529 0.00374452249351411 1.08001235712079 0.666666666666667 2.1 2 1 abnormal cytokine secretion 1.53308750945069e-12 1.13837468052495e-10 1.07299928986676 0.662337662337662 2.1 2 1 increased eosinophil cell number 7.53272488274682e-06 0.000158123655239095 1.07130258004724 0.661290322580645 2.1 2 1 pericardial effusion 7.53272488274682e-06 0.000158123655239095 1.07130258004724 0.661290322580645 2.1 2 1 abnormal vitelline vasculature morphology 1.19979729281043e-09 5.3774698484071e-08 1.07062094531974 0.660869565217391 2.1 2 1 atrioventricular septal defect 3.6290376020492e-05 0.000616193244716546 1.0698235612989 0.660377358490566 2.1 2 1 abnormal craniofacial morphology 9.3801862166866e-09 3.70368463714411e-07 1.06952680025554 0.660194174757282 2.1 2 1 neuron degeneration 0.000104199417908155 0.00157088516391839 1.06852286395993 0.659574468085106 2.1 2 1 abnormal T-helper 1 physiology 0.000104199417908155 0.00157088516391839 1.06852286395993 0.659574468085106 2.1 2 1 muscular atrophy 0.000177003196161094 0.00243930997479624 1.06773948942624 0.659090909090909 2.1 2 1 decreased blood urea nitrogen level 0.000177003196161094 0.00243930997479624 1.06773948942624 0.659090909090909 2.1 2 1 abnormal somite development 5.82783090044962e-07 1.57573145270309e-05 1.06634131462559 0.658227848101266 2.1 2 1 incomplete somite formation 0.000513928093456941 0.00613139631882082 1.06580166821131 0.657894736842105 2.1 2 1 abnormal humoral immune response 9.78389371849328e-09 3.83266702752e-07 1.06458360916192 0.657142857142857 2.1 2 1 decreased bone volume 0.000879009878089082 0.00959007487608154 1.06458360916192 0.657142857142857 2.1 2 1 decreased caudal vertebrae number 7.83177529675171e-06 0.00016302544812276 1.06313716404078 0.65625 2.1 2 1 scoliosis 0.00150807428563503 0.0151440256830886 1.06313716404078 0.65625 2.1 2 1 oxidative stress 1.28464666087765e-07 3.85007056497969e-06 1.06201215116878 0.655555555555556 2.1 2 1 increased double-positive T cell number 0.00259681912049474 0.023797290875435 1.06139145441181 0.655172413793103 2.1 2 1 polychromatophilia 0.00259681912049474 0.023797290875435 1.06139145441181 0.655172413793103 2.1 2 1 azoospermia 3.03492521423942e-12 2.01316705877882e-10 1.059634765477 0.654088050314465 2.1 2 1 distended pericardium 6.35906456634646e-05 0.00102382997467876 1.05924288871462 0.653846153846154 2.1 2 1 thick skin 0.00449138178890772 0.0365108241827058 1.05924288871462 0.653846153846154 2.1 2 1 heart inflammation 0.00449138178890772 0.0365108241827058 1.05924288871462 0.653846153846154 2.1 2 1 abnormal Mullerian duct morphology 0.00449138178890772 0.0365108241827058 1.05924288871462 0.653846153846154 2.1 2 1 decreased Peyer's patch number 0.00449138178890772 0.0365108241827058 1.05924288871462 0.653846153846154 2.1 2 1 abnormal allantois morphology 0.000182587812585007 0.00250240872619948 1.05653382761817 0.652173913043478 2.1 2 1 pancreas inflammation 0.00781049931077501 0.0569095577029907 1.05653382761817 0.652173913043478 2.1 2 1 abnormal lens development 0.00781049931077501 0.0569095577029907 1.05653382761817 0.652173913043478 2.1 2 1 abnormal male reproductive system morphology 0.000310164194318143 0.00397697646065144 1.05489579067612 0.651162790697674 2.1 2 1 gliosis 1.36203799629287e-05 0.000266777127226654 1.05429777718934 0.650793650793651 2.1 2 1 abnormal female reproductive system morphology 0.000527917507109288 0.00622367203286423 1.05301204819277 0.65 2.1 2 1 abnormal cell proliferation 0.0136756800420063 0.0873966688210078 1.05301204819277 0.65 2.1 2 1 abnormal vascular regression 0.0136756800420063 0.0873966688210078 1.05301204819277 0.65 2.1 2 1 brain inflammation 0.0136756800420063 0.0873966688210078 1.05301204819277 0.65 2.1 2 1 anencephaly 0.0136756800420063 0.0873966688210078 1.05301204819277 0.65 2.1 2 1 abnormal optic stalk morphology 0.0136756800420063 0.0873966688210078 1.05301204819277 0.65 2.1 2 1 abnormal sperm mitochondrial sheath morphology 0.0136756800420063 0.0873966688210078 1.05301204819277 0.65 2.1 2 1 enlarged liver 4.90716159608183e-08 1.61676350599385e-06 1.05301204819277 0.65 2.1 2 1 increased granulocyte number 2.94738391255214e-06 6.82010928602181e-05 1.05082283395536 0.648648648648649 2.1 2 1 abnormal branching of the mammary ductal tree 0.000900580220073529 0.00976119083848759 1.05082283395536 0.648648648648649 2.1 2 1 skin inflammation 0.000900580220073529 0.00976119083848759 1.05082283395536 0.648648648648649 2.1 2 1 increased leukocyte cell number 6.93898844542319e-11 3.87881657482925e-09 1.05021891278642 0.648275862068965 2.1 2 1 abnormal cell adhesion 6.53253852505202e-05 0.00104390568386404 1.05001201386744 0.648148148148148 2.1 2 1 abnormal neuronal precursor proliferation 6.53253852505202e-05 0.00104390568386404 1.05001201386744 0.648148148148148 2.1 2 1 pericardial edema 8.31185422764679e-06 0.00017017067811746 1.04824728779371 0.647058823529412 2.1 2 1 decreased circulating alanine transaminase level 8.31185422764679e-06 0.00017017067811746 1.04824728779371 0.647058823529412 2.1 2 1 decreased mean corpuscular hemoglobin 8.31185422764679e-06 0.00017017067811746 1.04824728779371 0.647058823529412 2.1 2 1 decreased regulatory T cell number 0.00154034294972554 0.0152668030957738 1.04824728779371 0.647058823529412 2.1 2 1 hyperlipidemia 0.0241585583571621 0.129933867920953 1.04824728779371 0.647058823529412 2.1 2 1 abnormal melanosome morphology 0.0241585583571621 0.129933867920953 1.04824728779371 0.647058823529412 2.1 2 1 enhanced behavioral response to cocaine 0.0241585583571621 0.129933867920953 1.04824728779371 0.647058823529412 2.1 2 1 increased hepatoma incidence 0.0241585583571621 0.129933867920953 1.04824728779371 0.647058823529412 2.1 2 1 abnormal dendritic cell physiology 3.10245950704574e-08 1.07935217115752e-06 1.04468485011217 0.644859813084112 2.1 2 1 small placenta 0.000316649307864752 0.00403930847853113 1.04401194521676 0.644444444444444 2.1 2 1 abnormal testis morphology 1.14230990173615e-08 4.37153212395181e-07 1.04244670991659 0.643478260869565 2.1 2 1 hydroencephaly 1.14230990173615e-08 4.37153212395181e-07 1.04244670991659 0.643478260869565 2.1 2 1 abnormal coat/hair pigmentation 1.90375628974737e-08 6.91327557773224e-07 1.04144048722362 0.642857142857143 2.1 2 1 small superior cervical ganglion 0.00455051075819252 0.0367815027370049 1.04144048722362 0.642857142857143 2.1 2 1 abnormal ovulation 0.00455051075819252 0.0367815027370049 1.04144048722362 0.642857142857143 2.1 2 1 midline facial cleft 0.0431900555308446 0.198034438380269 1.04144048722362 0.642857142857143 2.1 2 1 increased lactate dehydrogenase level 0.0431900555308446 0.198034438380269 1.04144048722362 0.642857142857143 2.1 2 1 split sternum 0.0431900555308446 0.198034438380269 1.04144048722362 0.642857142857143 2.1 2 1 increased pulmonary respiratory rate 0.0431900555308446 0.198034438380269 1.04144048722362 0.642857142857143 2.1 2 1 decreased compact bone area 0.0431900555308446 0.198034438380269 1.04144048722362 0.642857142857143 2.1 2 1 internal hemorrhage 1.42554183079912e-05 0.000277034008133813 1.03971338857151 0.641791044776119 2.1 2 1 increased sacral vertebrae number 2.39391969765486e-05 0.000425348231994032 1.03782437442076 0.640625 2.1 2 1 ruffled hair 0.00787010566827288 0.0569095577029907 1.03681186283596 0.64 2.1 2 1 abnormal primitive streak morphology 0.00787010566827288 0.0569095577029907 1.03681186283596 0.64 2.1 2 1 abnormal egg cylinder morphology 0.00787010566827288 0.0569095577029907 1.03681186283596 0.64 2.1 2 1 increased pre-B cell number 0.00787010566827288 0.0569095577029907 1.03681186283596 0.64 2.1 2 1 abnormal forebrain development 8.63864181717551e-06 0.00017613624196905 1.03501184224076 0.638888888888889 2.1 2 1 decreased bone trabecula number 0.000320920273779459 0.00405870128902711 1.03405438447735 0.638297872340426 2.1 2 1 abnormal sternum morphology 1.44740886594349e-05 0.000278025448187987 1.03305529811554 0.63768115942029 2.1 2 1 decreased spleen weight 1.44740886594349e-05 0.000278025448187987 1.03305529811554 0.63768115942029 2.1 2 1 perimembraneous ventricular septal defect 1.44740886594349e-05 0.000278025448187987 1.03305529811554 0.63768115942029 2.1 2 1 small ovary 6.81918714016795e-07 1.8141955092158e-05 1.03253928647812 0.637362637362637 2.1 2 1 kinked tail 1.49431814171607e-07 4.29724436707367e-06 1.03236475313017 0.637254901960784 2.1 2 1 abnormal behavior 5.42012467568907e-18 8.42660008173535e-16 1.03145065041572 0.636690647482014 2.1 2 1 abnormal gametogenesis 0.000543195941092979 0.00626928464377208 1.03092088634257 0.636363636363636 2.1 2 1 decreased macrophage cell number 0.000543195941092979 0.00626928464377208 1.03092088634257 0.636363636363636 2.1 2 1 lethality, incomplete penetrance 0.000543195941092979 0.00626928464377208 1.03092088634257 0.636363636363636 2.1 2 1 abnormal abdominal fat pad morphology 0.0136848251279528 0.0873966688210078 1.03092088634257 0.636363636363636 2.1 2 1 abnormal tail movements 0.0136848251279528 0.0873966688210078 1.03092088634257 0.636363636363636 2.1 2 1 increased activated T cell number 0.0136848251279528 0.0873966688210078 1.03092088634257 0.636363636363636 2.1 2 1 abnormal chorion morphology 0.0136848251279528 0.0873966688210078 1.03092088634257 0.636363636363636 2.1 2 1 aphakia 0.0136848251279528 0.0873966688210078 1.03092088634257 0.636363636363636 2.1 2 1 abnormal mesenteric lymph node morphology 0.0136848251279528 0.0873966688210078 1.03092088634257 0.636363636363636 2.1 2 1 abnormal cerebral cortex pyramidal cell morphology 0.0136848251279528 0.0873966688210078 1.03092088634257 0.636363636363636 2.1 2 1 premature suture closure 0.0785366754201962 0.293996796249452 1.03092088634257 0.636363636363636 2.1 2 1 abnormal large intestine morphology 0.0785366754201962 0.293996796249452 1.03092088634257 0.636363636363636 2.1 2 1 failure of somite differentiation 0.0785366754201962 0.293996796249452 1.03092088634257 0.636363636363636 2.1 2 1 retinal detachment 0.0785366754201962 0.293996796249452 1.03092088634257 0.636363636363636 2.1 2 1 pathological neovascularization 0.0785366754201962 0.293996796249452 1.03092088634257 0.636363636363636 2.1 2 1 pharyngeal arch hypoplasia 0.0785366754201962 0.293996796249452 1.03092088634257 0.636363636363636 2.1 2 1 cyclopia 0.0785366754201962 0.293996796249452 1.03092088634257 0.636363636363636 2.1 2 1 increased glycogen level 0.0785366754201962 0.293996796249452 1.03092088634257 0.636363636363636 2.1 2 1 abnormal superovulation 0.0785366754201962 0.293996796249452 1.03092088634257 0.636363636363636 2.1 2 1 aberrant origin of the right subclavian artery 0.0785366754201962 0.293996796249452 1.03092088634257 0.636363636363636 2.1 2 1 common atrioventricular valve 0.0785366754201962 0.293996796249452 1.03092088634257 0.636363636363636 2.1 2 1 abnormal extraembryonic ectoderm morphology 0.0785366754201962 0.293996796249452 1.03092088634257 0.636363636363636 2.1 2 1 abnormal pulmonary alveolar sac morphology 0.0785366754201962 0.293996796249452 1.03092088634257 0.636363636363636 2.1 2 1 hypolactation 0.0785366754201962 0.293996796249452 1.03092088634257 0.636363636363636 2.1 2 1 double outlet right ventricle 9.10214480360687e-08 2.79525743197186e-06 1.02954448996561 0.635514018691589 2.1 2 1 Leydig cell hyperplasia 0.000920779337285502 0.00985134882364597 1.02732882750514 0.634146341463415 2.1 2 1 liver fibrosis 0.000920779337285502 0.00985134882364597 1.02732882750514 0.634146341463415 2.1 2 1 increased tumor growth/size 0.000920779337285502 0.00985134882364597 1.02732882750514 0.634146341463415 2.1 2 1 hemopericardium 0.000920779337285502 0.00985134882364597 1.02732882750514 0.634146341463415 2.1 2 1 increased bone trabecula number 0.000920779337285502 0.00985134882364597 1.02732882750514 0.634146341463415 2.1 2 1 kyphosis 3.66768574398284e-10 1.75449390156871e-08 1.02601173926475 0.633333333333333 2.1 2 1 liver inflammation 2.03080525536793e-08 7.28889737169761e-07 1.02601173926475 0.633333333333333 2.1 2 1 epidermal hyperplasia 6.82735215057081e-05 0.00106811562732987 1.02601173926475 0.633333333333333 2.1 2 1 increased erythrocyte cell number 6.82735215057081e-05 0.00106811562732987 1.02601173926475 0.633333333333333 2.1 2 1 gastrointestinal hemorrhage 0.00456164566607678 0.0367815027370049 1.02601173926475 0.633333333333333 2.1 2 1 abnormal cellular respiration 0.00456164566607678 0.0367815027370049 1.02601173926475 0.633333333333333 2.1 2 1 ventricular septal defect 2.738279407361e-09 1.17439138376043e-07 1.0244234857984 0.632352941176471 2.1 2 1 prenatal lethality, incomplete penetrance 7.89925052883623e-19 1.40352754932001e-16 1.02316960148285 0.631578947368421 2.1 2 1 absent vitelline blood vessels 0.0001146209644814 0.00169005156329059 1.02316960148285 0.631578947368421 2.1 2 1 decreased hair follicle number 0.00156341243713053 0.0154324937990563 1.02316960148285 0.631578947368421 2.1 2 1 irregular coat pigmentation 0.0239567514419204 0.129458140696044 1.02316960148285 0.631578947368421 2.1 2 1 small superior vagus ganglion 0.0239567514419204 0.129458140696044 1.02316960148285 0.631578947368421 2.1 2 1 abnormal stationary movement 0.0239567514419204 0.129458140696044 1.02316960148285 0.631578947368421 2.1 2 1 abnormal sternebra morphology 0.0239567514419204 0.129458140696044 1.02316960148285 0.631578947368421 2.1 2 1 decreased eye pigmentation 0.0239567514419204 0.129458140696044 1.02316960148285 0.631578947368421 2.1 2 1 decreased circulating magnesium level 0.0239567514419204 0.129458140696044 1.02316960148285 0.631578947368421 2.1 2 1 decreased tumor growth/size 0.000192544996429936 0.00261011269002433 1.02001167061408 0.62962962962963 2.1 2 1 decreased bone ossification 0.00784271545876056 0.0569095577029907 1.02001167061408 0.62962962962963 2.1 2 1 abnormal dermal layer morphology 0.00265952199403338 0.0239362145031824 1.01829736528532 0.628571428571429 2.1 2 1 decreased circulating thyroxine level 0.00265952199403338 0.0239362145031824 1.01829736528532 0.628571428571429 2.1 2 1 rib fusion 4.10737778614812e-05 0.000692684897833455 1.01553400744194 0.626865671641791 2.1 2 1 small spleen 1.93589877327937e-06 4.61317095532524e-05 1.01473688498712 0.626373626373626 2.1 2 1 abnormal neuron morphology 7.04208829409761e-07 1.86353134378381e-05 1.01455706274983 0.626262626262626 2.1 2 1 cleft palate 1.25945509726698e-08 4.74680993098731e-07 1.01405740401418 0.625954198473282 2.1 2 1 small heart 0.000544388133891364 0.00626928464377208 1.01251158480074 0.625 2.1 2 1 neonatal lethality 0.00453372831397866 0.0367815027370049 1.01251158480074 0.625 2.1 2 1 abnormal digestive system morphology 0.0135379809410962 0.0873966688210078 1.01251158480074 0.625 2.1 2 1 decreased mast cell number 0.0423047940343772 0.197036986330999 1.01251158480074 0.625 2.1 2 1 abnormal hair follicle orientation 0.0423047940343772 0.197036986330999 1.01251158480074 0.625 2.1 2 1 disorganized yolk sac vascular plexus 0.0423047940343772 0.197036986330999 1.01251158480074 0.625 2.1 2 1 small epididymis 0.0423047940343772 0.197036986330999 1.01251158480074 0.625 2.1 2 1 abnormal amnion morphology 0.0423047940343772 0.197036986330999 1.01251158480074 0.625 2.1 2 1 dystonia 0.0423047940343772 0.197036986330999 1.01251158480074 0.625 2.1 2 1 abnormal Langerhans cell physiology 0.0423047940343772 0.197036986330999 1.01251158480074 0.625 2.1 2 1 abnormal thoracic cage shape 0.0423047940343772 0.197036986330999 1.01251158480074 0.625 2.1 2 1 abnormal pulmonary alveolus wall morphology 0.0423047940343772 0.197036986330999 1.01251158480074 0.625 2.1 2 1 abnormal ear pigmentation 0.146583919176364 0.436941280948118 1.01251158480074 0.625 2.1 2 1 absent pre-B cells 0.146583919176364 0.436941280948118 1.01251158480074 0.625 2.1 2 1 failure of vascular branching 0.146583919176364 0.436941280948118 1.01251158480074 0.625 2.1 2 1 abnormal pupil morphology 0.146583919176364 0.436941280948118 1.01251158480074 0.625 2.1 2 1 abnormal hepatobiliary system morphology 0.146583919176364 0.436941280948118 1.01251158480074 0.625 2.1 2 1 vascular smooth muscle hypertrophy 0.146583919176364 0.436941280948118 1.01251158480074 0.625 2.1 2 1 decreased aerobic running capacity 0.146583919176364 0.436941280948118 1.01251158480074 0.625 2.1 2 1 abnormal soft palate morphology 0.146583919176364 0.436941280948118 1.01251158480074 0.625 2.1 2 1 abnormal cellular cholesterol metabolism 0.146583919176364 0.436941280948118 1.01251158480074 0.625 2.1 2 1 abnormal neuron apoptosis 0.146583919176364 0.436941280948118 1.01251158480074 0.625 2.1 2 1 decreased susceptibility to age related obesity 0.146583919176364 0.436941280948118 1.01251158480074 0.625 2.1 2 1 abnormal umbilical artery morphology 0.146583919176364 0.436941280948118 1.01251158480074 0.625 2.1 2 1 loss of GABAergic neurons 0.146583919176364 0.436941280948118 1.01251158480074 0.625 2.1 2 1 liver cysts 0.146583919176364 0.436941280948118 1.01251158480074 0.625 2.1 2 1 abnormal eyelid aperture 0.146583919176364 0.436941280948118 1.01251158480074 0.625 2.1 2 1 long femur 0.146583919176364 0.436941280948118 1.01251158480074 0.625 2.1 2 1 bowed fibula 0.146583919176364 0.436941280948118 1.01251158480074 0.625 2.1 2 1 absent cochlear microphonics 0.146583919176364 0.436941280948118 1.01251158480074 0.625 2.1 2 1 abnormal optic choroid morphology 0.146583919176364 0.436941280948118 1.01251158480074 0.625 2.1 2 1 non-pigmented tail tip 0.146583919176364 0.436941280948118 1.01251158480074 0.625 2.1 2 1 decreased susceptibility to autoimmune disorder 0.146583919176364 0.436941280948118 1.01251158480074 0.625 2.1 2 1 abnormal epidermal lamellar body morphology 0.146583919176364 0.436941280948118 1.01251158480074 0.625 2.1 2 1 enlarged inguinal lymph nodes 0.146583919176364 0.436941280948118 1.01251158480074 0.625 2.1 2 1 abnormal frontonasal prominence morphology 0.146583919176364 0.436941280948118 1.01251158480074 0.625 2.1 2 1 increased caudal vertebrae number 0.146583919176364 0.436941280948118 1.01251158480074 0.625 2.1 2 1 anomalous pulmonary venous connection 0.146583919176364 0.436941280948118 1.01251158480074 0.625 2.1 2 1 abnormal anterior commissure pars posterior morphology 0.146583919176364 0.436941280948118 1.01251158480074 0.625 2.1 2 1 abnormal maxillary prominence morphology 0.146583919176364 0.436941280948118 1.01251158480074 0.625 2.1 2 1 increased aorta wall thickness 0.146583919176364 0.436941280948118 1.01251158480074 0.625 2.1 2 1 impaired neuron differentiation 0.146583919176364 0.436941280948118 1.01251158480074 0.625 2.1 2 1 abnormal heart echocardiography feature 0.146583919176364 0.436941280948118 1.01251158480074 0.625 2.1 2 1 prolonged PQ interval 0.146583919176364 0.436941280948118 1.01251158480074 0.625 2.1 2 1 increased cornea thickness 0.146583919176364 0.436941280948118 1.01251158480074 0.625 2.1 2 1 increased testis apoptosis 0.146583919176364 0.436941280948118 1.01251158480074 0.625 2.1 2 1 absent hypoglossal canal 0.146583919176364 0.436941280948118 1.01251158480074 0.625 2.1 2 1 retropleural edema 0.146583919176364 0.436941280948118 1.01251158480074 0.625 2.1 2 1 decreased white adipose tissue mass 0.146583919176364 0.436941280948118 1.01251158480074 0.625 2.1 2 1 decreased basal metabolism 0.146583919176364 0.436941280948118 1.01251158480074 0.625 2.1 2 1 decreased hemoglobin content 4.63335937761306e-09 1.95347143251059e-07 1.01107539815563 0.624113475177305 2.1 2 1 increased osteoclast cell number 0.000114611389499947 0.00169005156329059 1.00919187468664 0.622950819672131 2.1 2 1 premature death 1.69153519031297e-47 1.40256459530117e-44 1.00851328121384 0.62253193960511 2.1 2 1 abnormal ovarian follicle morphology 0.000916331572292408 0.00985134882364597 1.00801153331274 0.622222222222222 2.1 2 1 abnormal bone structure 1.15590201348697e-11 7.09952162604652e-10 1.00726541078623 0.621761658031088 2.1 2 1 abnormal vocalization 0.00263840577824843 0.0239362145031824 1.00703854920722 0.621621621621622 2.1 2 1 increased circulating phosphate level 0.00263840577824843 0.0239362145031824 1.00703854920722 0.621621621621622 2.1 2 1 hemorrhage 7.917098885577e-14 7.29399388069363e-12 1.00647960089129 0.621276595744681 2.1 2 1 thrombocytosis 0.00019149324313605 0.0026029477721362 1.00552874628487 0.620689655172414 2.1 2 1 abnormal microglial cell morphology 0.00774746071078889 0.0566861942976443 1.00552874628487 0.620689655172414 2.1 2 1 short sternum 0.00774746071078889 0.0566861942976443 1.00552874628487 0.620689655172414 2.1 2 1 blood in lymph vessels 0.00774746071078889 0.0566861942976443 1.00552874628487 0.620689655172414 2.1 2 1 decreased body length 8.93782593670057e-16 9.66645305110551e-14 1.00512098929125 0.62043795620438 2.1 2 1 abnormal visceral yolk sac morphology 1.47130241639861e-05 0.000281528058522427 1.00482162339719 0.620253164556962 2.1 2 1 abnormal liver morphology 8.48706829227571e-11 4.69146275045241e-09 1.00459249977995 0.620111731843575 2.1 2 1 decreased circulating alkaline phosphatase level 0.000540730300483703 0.00626928464377208 1.00441149212234 0.62 2.1 2 1 cataract 9.37068206600187e-08 2.86007013977664e-06 1.00414372046355 0.619834710743802 2.1 2 1 skin edema 0.00154355818234658 0.0152668030957738 1.00286861732645 0.619047619047619 2.1 2 1 abnormal pancreas morphology 0.00154355818234658 0.0152668030957738 1.00286861732645 0.619047619047619 2.1 2 1 abnormal associative learning 0.0234824830467616 0.128238587439779 1.00286861732645 0.619047619047619 2.1 2 1 increased keratinocyte proliferation 0.0234824830467616 0.128238587439779 1.00286861732645 0.619047619047619 2.1 2 1 abnormal platelet physiology 0.000319985324074541 0.00405870128902711 1.00146600387564 0.618181818181818 2.1 2 1 abnormal endoderm development 0.00447443266981473 0.0365108241827058 1.00059968380309 0.617647058823529 2.1 2 1 embryonic lethality during organogenesis, incomplete penetrance 3.49170033609291e-13 2.80180793097778e-11 1.00018535681186 0.617391304347826 2.1 2 1 reduced female fertility 3.47338085796004e-13 2.80180793097778e-11 0.998545907769007 0.616379310344828 2.1 2 1 abnormal female meiosis 0.000534740428936259 0.00626928464377208 0.996934483496115 0.615384615384615 2.1 2 1 decreased circulating glycerol level 0.0132760638752572 0.0869058128676374 0.996934483496115 0.615384615384615 2.1 2 1 abnormal erythrocyte osmotic lysis 0.0132760638752572 0.0869058128676374 0.996934483496115 0.615384615384615 2.1 2 1 absent common myeloid progenitor cells 0.0755757009347722 0.292598530856414 0.996934483496115 0.615384615384615 2.1 2 1 increased foot pad pigmentation 0.0755757009347722 0.292598530856414 0.996934483496115 0.615384615384615 2.1 2 1 tight skin 0.0755757009347722 0.292598530856414 0.996934483496115 0.615384615384615 2.1 2 1 axonal dystrophy 0.0755757009347722 0.292598530856414 0.996934483496115 0.615384615384615 2.1 2 1 small pituitary gland 0.0755757009347722 0.292598530856414 0.996934483496115 0.615384615384615 2.1 2 1 empty decidua capsularis 0.0755757009347722 0.292598530856414 0.996934483496115 0.615384615384615 2.1 2 1 abnormal response to injury 0.00260215602738425 0.023797290875435 0.996934483496115 0.615384615384615 2.1 2 1 decreased trabecular bone volume 0.00260215602738425 0.023797290875435 0.996934483496115 0.615384615384615 2.1 2 1 abnormal rib morphology 3.37625473057407e-08 1.15914994222878e-06 0.996011396011396 0.614814814814815 2.1 2 1 increased macrophage cell number 0.00031623433559555 0.00403930847853113 0.994748223663886 0.614035087719298 2.1 2 1 absent mature ovarian follicles 0.00759998493911387 0.0562316621674441 0.992914586385243 0.612903225806452 2.1 2 1 abnormal capillary morphology 0.00759998493911387 0.0562316621674441 0.992914586385243 0.612903225806452 2.1 2 1 abnormal small intestine morphology 0.000526761326071653 0.00622367203286423 0.990011327360725 0.611111111111111 2.1 2 1 axon degeneration 0.000526761326071653 0.00622367203286423 0.990011327360725 0.611111111111111 2.1 2 1 decreased platelet aggregation 0.000526761326071653 0.00622367203286423 0.990011327360725 0.611111111111111 2.1 2 1 abnormal retinal blood vessel morphology 0.00439027166987402 0.0361293908017049 0.990011327360725 0.611111111111111 2.1 2 1 right pulmonary isomerism 0.0409742683549323 0.19525959818484 0.990011327360725 0.611111111111111 2.1 2 1 abnormal aerobic respiration 0.0409742683549323 0.19525959818484 0.990011327360725 0.611111111111111 2.1 2 1 abnormal mammary gland development 0.0025536521692289 0.0235703516547565 0.987816180293406 0.609756097560976 2.1 2 1 decreased circulating LDL cholesterol level 0.000184600971772489 0.0025230489960663 0.987198795180723 0.609375 2.1 2 1 abnormal nervous system physiology 6.6752069700936e-07 1.78543842345245e-05 0.986098239110287 0.608695652173913 2.1 2 1 abnormal cranial nerve morphology 0.022822665288007 0.126170697865558 0.986098239110287 0.608695652173913 2.1 2 1 failure of embryo implantation 0.022822665288007 0.126170697865558 0.986098239110287 0.608695652173913 2.1 2 1 abnormal nasal cavity morphology 0.022822665288007 0.126170697865558 0.986098239110287 0.608695652173913 2.1 2 1 abnormal cardiovascular development 0.022822665288007 0.126170697865558 0.986098239110287 0.608695652173913 2.1 2 1 abnormal regulatory T cell physiology 0.022822665288007 0.126170697865558 0.986098239110287 0.608695652173913 2.1 2 1 abnormal chondrocyte physiology 0.022822665288007 0.126170697865558 0.986098239110287 0.608695652173913 2.1 2 1 male infertility 3.44328827705315e-25 1.14202394522263e-22 0.98553811514601 0.608349900596421 2.1 2 1 abnormal eye development 0.000517105999750874 0.00615455107358994 0.983582682377863 0.607142857142857 2.1 2 1 shortened head 0.0129306681778202 0.0851911571163467 0.983582682377863 0.607142857142857 2.1 2 1 straub tail 0.0129306681778202 0.0851911571163467 0.983582682377863 0.607142857142857 2.1 2 1 abnormal male meiosis 0.000305746720590622 0.00394064749984028 0.982634193773834 0.60655737704918 2.1 2 1 belly spot 0.00741300143721159 0.0553579406019026 0.981829415564355 0.606060606060606 2.1 2 1 increased cardiomyocyte apoptosis 0.00741300143721159 0.0553579406019026 0.981829415564355 0.606060606060606 2.1 2 1 increased bone mineral content 1.79140827598669e-06 4.32633794807465e-05 0.980928654632645 0.605504587155963 2.1 2 1 abnormal immune system physiology 3.8874938666211e-07 1.0626528563978e-05 0.979849920774911 0.604838709677419 2.1 2 1 decreased total body fat amount 9.8916380326141e-17 1.28068904295665e-14 0.97977168924431 0.604790419161677 2.1 2 1 limb grasping 9.12068127137366e-10 4.16287975459486e-08 0.979132082005113 0.604395604395604 2.1 2 1 abnormal eye morphology 8.47801711315155e-08 2.61975994645522e-06 0.979004007174242 0.60431654676259 2.1 2 1 retinal degeneration 8.16000832892674e-06 0.000169150172651711 0.978761198640717 0.604166666666667 2.1 2 1 lung inflammation 1.38230968224586e-07 4.09344682688878e-06 0.976775881807774 0.602941176470588 2.1 2 1 decreased bone mineral density 2.78719835680456e-13 2.31105197085045e-11 0.97444723950748 0.601503759398496 2.1 2 1 preweaning lethality, incomplete penetrance 1.2925493076948e-19 2.38164177991912e-17 0.97438767671778 0.601466992665037 2.1 2 1 abnormal heart development 1.78698187710279e-08 6.53693738131351e-07 0.974061777782992 0.60126582278481 2.1 2 1 decreased bone mineral content 1.14868498413872e-10 6.14484709257003e-09 0.973568831539174 0.600961538461538 2.1 2 1 abnormal pericardium morphology 0.0393783585417917 0.188735388964753 0.972011121408712 0.6 2.1 2 1 abnormal physiological neovascularization 0.0393783585417917 0.188735388964753 0.972011121408712 0.6 2.1 2 1 abnormal induced retinal neovascularization 0.0393783585417917 0.188735388964753 0.972011121408712 0.6 2.1 2 1 abnormal neuron proliferation 0.0393783585417917 0.188735388964753 0.972011121408712 0.6 2.1 2 1 abnormal auchene hair morphology 0.137213302546225 0.436941280948118 0.972011121408712 0.6 2.1 2 1 increased cranium width 0.137213302546225 0.436941280948118 0.972011121408712 0.6 2.1 2 1 abnormal prostate gland epithelium morphology 0.137213302546225 0.436941280948118 0.972011121408712 0.6 2.1 2 1 abnormal mammary gland physiology 0.137213302546225 0.436941280948118 0.972011121408712 0.6 2.1 2 1 abnormal airway responsiveness 0.137213302546225 0.436941280948118 0.972011121408712 0.6 2.1 2 1 ketoaciduria 0.137213302546225 0.436941280948118 0.972011121408712 0.6 2.1 2 1 abnormal neuron specification 0.137213302546225 0.436941280948118 0.972011121408712 0.6 2.1 2 1 aneurysm 0.137213302546225 0.436941280948118 0.972011121408712 0.6 2.1 2 1 absent seminal vesicle 0.137213302546225 0.436941280948118 0.972011121408712 0.6 2.1 2 1 increased heart rate variability 0.137213302546225 0.436941280948118 0.972011121408712 0.6 2.1 2 1 abnormal reproductive system development 0.137213302546225 0.436941280948118 0.972011121408712 0.6 2.1 2 1 decreased cochlear inner hair cell number 0.137213302546225 0.436941280948118 0.972011121408712 0.6 2.1 2 1 increased susceptibility to atherosclerosis 0.137213302546225 0.436941280948118 0.972011121408712 0.6 2.1 2 1 tachypnea 0.137213302546225 0.436941280948118 0.972011121408712 0.6 2.1 2 1 abnormal developmental vascular remodeling 0.137213302546225 0.436941280948118 0.972011121408712 0.6 2.1 2 1 absent axillary lymph nodes 0.137213302546225 0.436941280948118 0.972011121408712 0.6 2.1 2 1 decreased transitional stage T2 B cell number 0.137213302546225 0.436941280948118 0.972011121408712 0.6 2.1 2 1 abnormal hippocampus neuron morphology 0.137213302546225 0.436941280948118 0.972011121408712 0.6 2.1 2 1 abnormal heart and great artery attachment 0.137213302546225 0.436941280948118 0.972011121408712 0.6 2.1 2 1 aorta stenosis 0.137213302546225 0.436941280948118 0.972011121408712 0.6 2.1 2 1 thick aortic valve cusps 0.137213302546225 0.436941280948118 0.972011121408712 0.6 2.1 2 1 fusion of atlas and odontoid process 0.137213302546225 0.436941280948118 0.972011121408712 0.6 2.1 2 1 domed cranium 0.000173368116249917 0.00240252473076138 0.972011121408712 0.6 2.1 2 1 muscular ventricular septal defect 0.000493870991708908 0.00592050164759474 0.972011121408712 0.6 2.1 2 1 trabecula carnea hypoplasia 0.00242947871537516 0.0228481221341993 0.972011121408712 0.6 2.1 2 1 abnormal cell migration 0.00242947871537516 0.0228481221341993 0.972011121408712 0.6 2.1 2 1 increased circulating serum albumin level 0.00719679868348671 0.0544134854868486 0.972011121408712 0.6 2.1 2 1 decreased glycogen level 0.00719679868348671 0.0544134854868486 0.972011121408712 0.6 2.1 2 1 abnormal hippocampus pyramidal cell morphology 0.00719679868348671 0.0544134854868486 0.972011121408712 0.6 2.1 2 1 liver hemorrhage 0.012526183277857 0.0832012841219475 0.972011121408712 0.6 2.1 2 1 mandible hypoplasia 0.0220397938503313 0.123616656601351 0.972011121408712 0.6 2.1 2 1 abnormal keratinocyte physiology 0.0220397938503313 0.123616656601351 0.972011121408712 0.6 2.1 2 1 audiogenic seizures 0.0720261094056876 0.286878659400099 0.972011121408712 0.6 2.1 2 1 placental labyrinth hypoplasia 0.0720261094056876 0.286878659400099 0.972011121408712 0.6 2.1 2 1 abnormal lymph node B cell domain morphology 0.0720261094056876 0.286878659400099 0.972011121408712 0.6 2.1 2 1 abnormal neurotransmitter secretion 0.0720261094056876 0.286878659400099 0.972011121408712 0.6 2.1 2 1 liver vascular congestion 0.0720261094056876 0.286878659400099 0.972011121408712 0.6 2.1 2 1 bicuspid aortic valve 0.0720261094056876 0.286878659400099 0.972011121408712 0.6 2.1 2 1 abnormal microglial cell activation 0.0720261094056876 0.286878659400099 0.972011121408712 0.6 2.1 2 1 increased circulating alkaline phosphatase level 1.71346701862033e-08 6.31444327232305e-07 0.970011098525155 0.598765432098765 2.1 2 1 abnormal heart morphology 2.32834321001513e-11 1.3956033096175e-09 0.967803281056293 0.597402597402597 2.1 2 1 perinatal lethality, incomplete penetrance 3.85214373364971e-11 2.25463706763615e-09 0.967710187243187 0.597345132743363 2.1 2 1 abnormal inflammatory response 0.000168990613201639 0.00237493870248066 0.967511069920708 0.597222222222222 2.1 2 1 decreased compact bone thickness 0.000284708839545701 0.00368861061651006 0.967175245182798 0.597014925373134 2.1 2 1 abnormal snout morphology 0.00138275071057736 0.0139820828965902 0.965780280886861 0.596153846153846 2.1 2 1 hepatic necrosis 0.00235776257730891 0.022342607280213 0.965117425512196 0.595744680851064 2.1 2 1 abnormal nervous system morphology 9.78326722609602e-05 0.00148389495273865 0.963808495911592 0.594936708860759 2.1 2 1 reduced male fertility 5.93486291768515e-11 3.35522079721405e-09 0.963447146770749 0.594713656387665 2.1 2 1 abnormal calcium ion homeostasis 0.00695967497759158 0.052942481672046 0.963254264459084 0.594594594594595 2.1 2 1 increased trabecular bone volume 0.00695967497759158 0.052942481672046 0.963254264459084 0.594594594594595 2.1 2 1 abnormal vertebral body morphology 0.012081436929696 0.0806182269247369 0.961886005560704 0.59375 2.1 2 1 increased fatty acid level 0.012081436929696 0.0806182269247369 0.961886005560704 0.59375 2.1 2 1 pancreatic islet hyperplasia 0.012081436929696 0.0806182269247369 0.961886005560704 0.59375 2.1 2 1 increased oxygen consumption 5.67033803265691e-05 0.000921893193217913 0.960708666508611 0.593023255813954 2.1 2 1 diluted coat color 0.00134011335312827 0.0135785416126541 0.96001098410737 0.592592592592593 2.1 2 1 neurodegeneration 0.00134011335312827 0.0135785416126541 0.96001098410737 0.592592592592593 2.1 2 1 increased brain weight 0.0211791161174341 0.120764627197476 0.96001098410737 0.592592592592593 2.1 2 1 abnormal bone trabecula morphology 0.0211791161174341 0.120764627197476 0.96001098410737 0.592592592592593 2.1 2 1 decreased heart weight 9.50650158064823e-05 0.00144632554629128 0.96001098410737 0.592592592592593 2.1 2 1 abnormal enzyme/coenzyme activity 6.91092686259766e-08 2.21872870603011e-06 0.95962881412962 0.592356687898089 2.1 2 1 insulin resistance 8.70622527007261e-07 2.267720980032e-05 0.957283680175246 0.590909090909091 2.1 2 1 embryonic lethality, incomplete penetrance 0.00390196925049643 0.0330141105803056 0.957283680175246 0.590909090909091 2.1 2 1 abnormal facial nerve morphology 0.0376346555961522 0.187045366224632 0.957283680175246 0.590909090909091 2.1 2 1 increased body size 0.0376346555961522 0.187045366224632 0.957283680175246 0.590909090909091 2.1 2 1 intracerebral hemorrhage 0.0376346555961522 0.187045366224632 0.957283680175246 0.590909090909091 2.1 2 1 cleft upper lip 0.0376346555961522 0.187045366224632 0.957283680175246 0.590909090909091 2.1 2 1 abnormal sperm midpiece morphology 0.0376346555961522 0.187045366224632 0.957283680175246 0.590909090909091 2.1 2 1 enlarged heart 8.60138692060391e-11 4.70240658571477e-09 0.956648876673804 0.59051724137931 2.1 2 1 short tail 9.22262406934847e-05 0.00140744032960149 0.956396484920218 0.590361445783133 2.1 2 1 female infertility 3.98959260237778e-12 2.57769132426357e-10 0.956176353766715 0.590225563909774 2.1 2 1 reduced fertility 5.09208547106395e-07 1.38432378243405e-05 0.955694387955808 0.589928057553957 2.1 2 1 postnatal growth retardation 6.42805854037955e-26 2.4599685567991e-23 0.955599168923053 0.589869281045752 2.1 2 1 alopecia 3.19160231086728e-05 0.000551327135297385 0.954958294717331 0.589473684210526 2.1 2 1 decreased birth weight 3.19160231086728e-05 0.000551327135297385 0.954958294717331 0.589473684210526 2.1 2 1 lung hemorrhage 0.0116109568192071 0.0784843888254828 0.952952079812463 0.588235294117647 2.1 2 1 abnormal vision 0.0116109568192071 0.0784843888254828 0.952952079812463 0.588235294117647 2.1 2 1 abnormal brown adipose tissue morphology 0.0116109568192071 0.0784843888254828 0.952952079812463 0.588235294117647 2.1 2 1 abnormal nervous system development 0.0116109568192071 0.0784843888254828 0.952952079812463 0.588235294117647 2.1 2 1 increased susceptibility to viral infection induced morbidity/mortality 0.0116109568192071 0.0784843888254828 0.952952079812463 0.588235294117647 2.1 2 1 abnormal bone marrow cavity morphology 0.0682279878589705 0.278910632373359 0.952952079812463 0.588235294117647 2.1 2 1 abnormal dorsal-ventral axis patterning 0.0682279878589705 0.278910632373359 0.952952079812463 0.588235294117647 2.1 2 1 aminoaciduria 0.0682279878589705 0.278910632373359 0.952952079812463 0.588235294117647 2.1 2 1 abnormal tarsal bone morphology 0.0682279878589705 0.278910632373359 0.952952079812463 0.588235294117647 2.1 2 1 coloboma 0.0682279878589705 0.278910632373359 0.952952079812463 0.588235294117647 2.1 2 1 increased circulating magnesium level 0.0682279878589705 0.278910632373359 0.952952079812463 0.588235294117647 2.1 2 1 common atrium 0.0682279878589705 0.278910632373359 0.952952079812463 0.588235294117647 2.1 2 1 abnormal survival 0.0682279878589705 0.278910632373359 0.952952079812463 0.588235294117647 2.1 2 1 abnormal ductus venosus valve morphology 0.0682279878589705 0.278910632373359 0.952952079812463 0.588235294117647 2.1 2 1 decreased body fat mass 0.0682279878589705 0.278910632373359 0.952952079812463 0.588235294117647 2.1 2 1 abnormal cell cytoskeleton morphology 0.0682279878589705 0.278910632373359 0.952952079812463 0.588235294117647 2.1 2 1 increased circulating aspartate transaminase level 0.000739006680791219 0.00822496249873896 0.951439457463554 0.587301587301587 2.1 2 1 decreased body weight 2.7086364111021e-50 3.36886653630824e-47 0.951335602132651 0.587237479806139 2.1 2 1 cachexia 1.79375456984348e-05 0.000332982424812363 0.950203179582234 0.586538461538462 2.1 2 1 abnormal retinal pigmentation 8.64194879661707e-05 0.00132288293117446 0.949666038157937 0.586206896551724 2.1 2 1 abnormal parietal bone morphology 0.0202735454227814 0.120764627197476 0.949666038157937 0.586206896551724 2.1 2 1 abnormal outer ear morphology 0.0202735454227814 0.120764627197476 0.949666038157937 0.586206896551724 2.1 2 1 decreased bone strength 0.0202735454227814 0.120764627197476 0.949666038157937 0.586206896551724 2.1 2 1 increased mean corpuscular hemoglobin 2.99198679950788e-05 0.000520459242222088 0.949101768378877 0.585858585858586 2.1 2 1 scaly skin 0.00644802726680538 0.0495810442849409 0.94830353308167 0.585365853658537 2.1 2 1 abnormal axon morphology 1.67632395403655e-05 0.000312348751735274 0.945010812480692 0.583333333333333 2.1 2 1 overriding aortic valve 0.00361429888025099 0.0306845340089568 0.945010812480692 0.583333333333333 2.1 2 1 oligodactyly 0.00361429888025099 0.0306845340089568 0.945010812480692 0.583333333333333 2.1 2 1 abnormal truncus arteriosus septation 0.0358212233736821 0.179991526236556 0.945010812480692 0.583333333333333 2.1 2 1 abnormal pilomotor reflex 0.127799919550268 0.436941280948118 0.945010812480692 0.583333333333333 2.1 2 1 decreased synaptic depression 0.127799919550268 0.436941280948118 0.945010812480692 0.583333333333333 2.1 2 1 decreased circulating ketone body level 0.127799919550268 0.436941280948118 0.945010812480692 0.583333333333333 2.1 2 1 absent ovary 0.127799919550268 0.436941280948118 0.945010812480692 0.583333333333333 2.1 2 1 decreased left ventricle systolic pressure 0.127799919550268 0.436941280948118 0.945010812480692 0.583333333333333 2.1 2 1 abnormal rostral-caudal body axis extension 0.127799919550268 0.436941280948118 0.945010812480692 0.583333333333333 2.1 2 1 abnormal cochlear outer hair cell physiology 0.127799919550268 0.436941280948118 0.945010812480692 0.583333333333333 2.1 2 1 abnormal fatty acid level 0.127799919550268 0.436941280948118 0.945010812480692 0.583333333333333 2.1 2 1 impaired behavioral response to cocaine 0.127799919550268 0.436941280948118 0.945010812480692 0.583333333333333 2.1 2 1 abnormal response to infection 0.000234063933216693 0.0030969895418964 0.943301932168792 0.582278481012658 2.1 2 1 decreased white adipose tissue amount 0.000686504662340592 0.00777986490921286 0.942995864053228 0.582089552238806 2.1 2 1 abnormal vasculogenesis 0.0061831160827434 0.0483663561503906 0.941871241675108 0.581395348837209 2.1 2 1 decreased circulating glucose level 1.15251560653237e-11 7.09952162604652e-10 0.940655923943915 0.580645161290323 2.1 2 1 prenatal lethality 0.00115799676616915 0.0121797757118214 0.940655923943915 0.580645161290323 2.1 2 1 abnormal postnatal growth/weight/body size 0.0193470732853475 0.11624600192585 0.940655923943915 0.580645161290323 2.1 2 1 abnormal interventricular septum morphology 0.00346763946743117 0.0298468968001212 0.939610750695088 0.58 2.1 2 1 abnormal circulating protein level 0.00346763946743117 0.0298468968001212 0.939610750695088 0.58 2.1 2 1 decreased respiratory quotient 0.00346763946743117 0.0298468968001212 0.939610750695088 0.58 2.1 2 1 abnormal blood vessel morphology 1.07423831789665e-06 2.71286072666793e-05 0.938493496532549 0.579310344827586 2.1 2 1 decreased circulating cholesterol level 4.55970219842925e-08 1.52705794093087e-06 0.938371392252491 0.579234972677596 2.1 2 1 persistence of hyaloid vascular system 0.0106349758324981 0.0734590052016007 0.93790546802595 0.578947368421053 2.1 2 1 enlarged adrenal glands 0.0643733541103238 0.266926919085063 0.93790546802595 0.578947368421053 2.1 2 1 abnormal long term depression 0.0643733541103238 0.266926919085063 0.93790546802595 0.578947368421053 2.1 2 1 delayed sexual maturation 0.0643733541103238 0.266926919085063 0.93790546802595 0.578947368421053 2.1 2 1 abnormal response to novelty 0.0643733541103238 0.266926919085063 0.93790546802595 0.578947368421053 2.1 2 1 abnormal cochlear inner hair cell morphology 0.0643733541103238 0.266926919085063 0.93790546802595 0.578947368421053 2.1 2 1 decreased fertilization frequency 0.0643733541103238 0.266926919085063 0.93790546802595 0.578947368421053 2.1 2 1 shortened RR interval 0.0643733541103238 0.266926919085063 0.93790546802595 0.578947368421053 2.1 2 1 right-sided stomach 0.0643733541103238 0.266926919085063 0.93790546802595 0.578947368421053 2.1 2 1 abnormal bone mineralization 8.72103111758185e-06 0.000177090325754978 0.937200805765976 0.578512396694215 2.1 2 1 abnormal myocardial trabeculae morphology 0.00591695629855707 0.0467994556205428 0.936010709504685 0.577777777777778 2.1 2 1 abnormal nasal bone morphology 0.0339903347254321 0.171502956652155 0.934626078277607 0.576923076923077 2.1 2 1 ventricular hypoplasia 0.0339903347254321 0.171502956652155 0.934626078277607 0.576923076923077 2.1 2 1 abnormal stomach morphology 0.0339903347254321 0.171502956652155 0.934626078277607 0.576923076923077 2.1 2 1 increased susceptibility to otitis media 0.0339903347254321 0.171502956652155 0.934626078277607 0.576923076923077 2.1 2 1 abnormal nerve conduction 0.0339903347254321 0.171502956652155 0.934626078277607 0.576923076923077 2.1 2 1 abnormal skin morphology 0.00106600445648419 0.011259813526558 0.932737944786138 0.575757575757576 2.1 2 1 enlarged pericardium 0.0184171708123535 0.112423834099949 0.932737944786138 0.575757575757576 2.1 2 1 dextrocardia 0.0184171708123535 0.112423834099949 0.932737944786138 0.575757575757576 2.1 2 1 abnormal locomotor coordination 0.0184171708123535 0.112423834099949 0.932737944786138 0.575757575757576 2.1 2 1 edema 1.90088196695582e-07 5.37323169636659e-06 0.932452529258357 0.575581395348837 2.1 2 1 increased respiratory quotient 0.00565221968858271 0.0447767403673551 0.930648946029618 0.574468085106383 2.1 2 1 abnormal osteoblast physiology 0.00317583139237623 0.0276219600997758 0.930010640854014 0.574074074074074 2.1 2 1 decreased body size 8.18092669888732e-29 3.70001002972404e-26 0.929785074363388 0.573934837092732 2.1 2 1 increased insulin sensitivity 2.51744693499928e-06 5.87995234817906e-05 0.928961677803198 0.573426573426573 2.1 2 1 decreased neutrophil cell number 2.12858898305341e-05 0.000383685876474302 0.927702922142218 0.572649572649573 2.1 2 1 abnormal craniofacial development 0.00539099538781329 0.0427754418730002 0.925724877532107 0.571428571428571 2.1 2 1 abnormal lung morphology 2.04138972073733e-05 0.000374231726703141 0.925724877532106 0.571428571428571 2.1 2 1 arrest of spermatogenesis 0.000319513220773419 0.00405870128902711 0.925724877532106 0.571428571428571 2.1 2 1 decreased susceptibility to hepatic steatosis 0.00171665021333972 0.0168116826995376 0.925724877532106 0.571428571428571 2.1 2 1 decreased bone mineralization 0.0174965010001675 0.107330570253802 0.925724877532106 0.571428571428571 2.1 2 1 trunk curl 0.0605728592018317 0.254733706279892 0.925724877532106 0.571428571428571 2.1 2 1 abnormal embryonic/fetal subventricular zone morphology 0.0605728592018317 0.254733706279892 0.925724877532106 0.571428571428571 2.1 2 1 increased acute inflammation 0.0605728592018317 0.254733706279892 0.925724877532106 0.571428571428571 2.1 2 1 abnormal clavicle morphology 0.0605728592018317 0.254733706279892 0.925724877532106 0.571428571428571 2.1 2 1 increased bone resorption 0.0321770467035859 0.168011159193582 0.925724877532106 0.571428571428571 2.1 2 1 abnormal interparietal bone morphology 0.118756561473342 0.413735219418682 0.925724877532106 0.571428571428571 2.1 2 1 decreased coping response 0.118756561473342 0.413735219418682 0.925724877532106 0.571428571428571 2.1 2 1 amyloid beta deposits 0.118756561473342 0.413735219418682 0.925724877532106 0.571428571428571 2.1 2 1 abnormal sagittal suture morphology 0.118756561473342 0.413735219418682 0.925724877532106 0.571428571428571 2.1 2 1 abnormal iris pigmentation 0.118756561473342 0.413735219418682 0.925724877532106 0.571428571428571 2.1 2 1 abnormal glucose tolerance 0.118756561473342 0.413735219418682 0.925724877532106 0.571428571428571 2.1 2 1 spina bifida occulta 0.118756561473342 0.413735219418682 0.925724877532106 0.571428571428571 2.1 2 1 abnormal vertebrae morphology 5.59360685808432e-05 0.000912399807179327 0.921478433139757 0.568807339449541 2.1 2 1 increased heart weight 6.04304779978049e-06 0.000130713751321339 0.920729959128156 0.568345323741007 2.1 2 1 perinatal lethality, complete penetrance 2.51572436439141e-08 8.81389345975158e-07 0.92029221980011 0.568075117370892 2.1 2 1 abnormal intestine morphology 0.000890765874743133 0.00969706833008115 0.919469979710944 0.567567567567568 2.1 2 1 abnormal long bone metaphysis morphology 0.0165941547540453 0.102173168194771 0.919469979710944 0.567567567567568 2.1 2 1 abnormal synaptic transmission 0.0304047113046053 0.160576898875171 0.918010503552672 0.566666666666667 2.1 2 1 abnormal fat pad morphology 0.0304047113046053 0.160576898875171 0.918010503552672 0.566666666666667 2.1 2 1 abnormal coat/ hair morphology 0.00488515717146032 0.0391363235555798 0.916991623970483 0.566037735849057 2.1 2 1 abnormal placenta development 0.00488515717146032 0.0391363235555798 0.916991623970483 0.566037735849057 2.1 2 1 increased circulating bilirubin level 0.00488515717146032 0.0391363235555798 0.916991623970483 0.566037735849057 2.1 2 1 abnormal axial skeleton morphology 0.000849645381728753 0.0092900786243968 0.916589434661724 0.565789473684211 2.1 2 1 abnormal skeleton morphology 4.88778997709564e-05 0.000818745964176795 0.91566265060241 0.565217391304348 2.1 2 1 conjunctivitis 0.0568902429967408 0.240466405190132 0.91566265060241 0.565217391304348 2.1 2 1 abnormal sacral vertebrae morphology 0.0568902429967408 0.240466405190132 0.91566265060241 0.565217391304348 2.1 2 1 decreased epididymis weight 0.0568902429967408 0.240466405190132 0.91566265060241 0.565217391304348 2.1 2 1 dilated heart 0.0568902429967408 0.240466405190132 0.91566265060241 0.565217391304348 2.1 2 1 abnormal ulna morphology 0.0568902429967408 0.240466405190132 0.91566265060241 0.565217391304348 2.1 2 1 increased rib number 0.000809780198378454 0.0089327194832213 0.913856609871438 0.564102564102564 2.1 2 1 decreased eosinophil cell number 0.0024943079876449 0.0233030575903884 0.911260426320667 0.5625 2.1 2 1 curly tail 0.00827240358500915 0.0584591020389496 0.911260426320667 0.5625 2.1 2 1 increased circulating follicle stimulating hormone level 0.0286886057426139 0.152811363564779 0.911260426320667 0.5625 2.1 2 1 abnormal lymphatic vessel morphology 0.0286886057426139 0.152811363564779 0.911260426320667 0.5625 2.1 2 1 abnormal extraembryonic endoderm formation 0.110239229168801 0.388413714670527 0.911260426320667 0.5625 2.1 2 1 paternal imprinting 0.110239229168801 0.388413714670527 0.911260426320667 0.5625 2.1 2 1 large intestinal inflammation 0.110239229168801 0.388413714670527 0.911260426320667 0.5625 2.1 2 1 increased pancreatic beta cell number 0.110239229168801 0.388413714670527 0.911260426320667 0.5625 2.1 2 1 decreased aggression towards mice 0.110239229168801 0.388413714670527 0.911260426320667 0.5625 2.1 2 1 small pancreas 0.110239229168801 0.388413714670527 0.911260426320667 0.5625 2.1 2 1 increased thymus weight 0.110239229168801 0.388413714670527 0.911260426320667 0.5625 2.1 2 1 embryonic lethality between somite formation and embryo turning, incomplete penetrance 0.110239229168801 0.388413714670527 0.911260426320667 0.5625 2.1 2 1 decreased litter size 5.68310608535435e-10 2.64237876398485e-08 0.910900101913265 0.562277580071174 2.1 2 1 abnormal retina morphology 8.45350173647268e-08 2.61975994645522e-06 0.910296129573238 0.561904761904762 2.1 2 1 increased circulating HDL cholesterol level 0.000133182068050404 0.00193172241559989 0.910296129573238 0.561904761904762 2.1 2 1 decreased grip strength 4.72168511819456e-08 1.5660255642012e-06 0.909873424149708 0.561643835616438 2.1 2 1 abnormal lipid homeostasis 2.35093292233685e-05 0.000420715513979346 0.909702716190205 0.561538461538462 2.1 2 1 abnormal craniofacial bone morphology 0.0044081487872633 0.0361293908017049 0.909484090206982 0.56140350877193 2.1 2 1 decreased susceptibility to induced arthritis 0.0044081487872633 0.0361293908017049 0.909484090206982 0.56140350877193 2.1 2 1 abnormal facial morphology 0.0044081487872633 0.0361293908017049 0.909484090206982 0.56140350877193 2.1 2 1 polydactyly 0.00023085770704956 0.00306271224685749 0.909194076147605 0.561224489795918 2.1 2 1 thick ventricular wall 0.0148681131644308 0.0923456466829503 0.908790885869934 0.560975609756098 2.1 2 1 short stride length 0.00783890292284503 0.0569095577029907 0.907210379981464 0.56 2.1 2 1 abnormal nest building behavior 0.0533612245852196 0.236391528085669 0.907210379981464 0.56 2.1 2 1 abnormal brain morphology 3.64902412388502e-06 8.21443213408505e-05 0.905600423672713 0.559006211180124 2.1 2 1 delayed endochondral bone ossification 0.0140517423658886 0.0896248952183277 0.904196392008104 0.558139534883721 2.1 2 1 absent corpus luteum 0.0074218585691395 0.0553579406019026 0.903471875668354 0.557692307692308 2.1 2 1 teratozoospermia 0.000630532670718616 0.00716187223019432 0.902055775549751 0.556818181818182 2.1 2 1 microphthalmia 9.27025575806528e-06 0.000187477733318597 0.900010297600659 0.555555555555556 2.1 2 1 abnormal maxilla morphology 0.00702181439531544 0.0533336284224341 0.900010297600659 0.555555555555556 2.1 2 1 abnormal trigeminal ganglion morphology 0.0500043579854297 0.225950663921447 0.900010297600659 0.555555555555556 2.1 2 1 abnormal brain commissure morphology 0.0500043579854297 0.225950663921447 0.900010297600659 0.555555555555556 2.1 2 1 abnormal motor coordination/ balance 0.000327659195841299 0.00412684683369737 0.900010297600659 0.555555555555556 2.1 2 1 increased susceptibility to parasitic infection 0.000598764082734262 0.00683222777890586 0.900010297600659 0.555555555555556 2.1 2 1 decreased osteoclast cell number 0.0132692110400232 0.0869058128676374 0.900010297600659 0.555555555555556 2.1 2 1 abnormal uterus morphology 0.0254597066221963 0.136489267721365 0.900010297600659 0.555555555555556 2.1 2 1 impaired wound healing 0.0254597066221963 0.136489267721365 0.900010297600659 0.555555555555556 2.1 2 1 abnormal limb bone morphology 0.0254597066221963 0.136489267721365 0.900010297600659 0.555555555555556 2.1 2 1 lowered ear position 0.102295137239018 0.364293706345107 0.900010297600659 0.555555555555556 2.1 2 1 cortical renal glomerulopathies 0.102295137239018 0.364293706345107 0.900010297600659 0.555555555555556 2.1 2 1 abnormal radius morphology 0.102295137239018 0.364293706345107 0.900010297600659 0.555555555555556 2.1 2 1 eye inflammation 0.102295137239018 0.364293706345107 0.900010297600659 0.555555555555556 2.1 2 1 abnormal metacarpal bone morphology 0.102295137239018 0.364293706345107 0.900010297600659 0.555555555555556 2.1 2 1 decreased activity of thyroid 0.102295137239018 0.364293706345107 0.900010297600659 0.555555555555556 2.1 2 1 increased susceptibility to autoimmune disorder 0.102295137239018 0.364293706345107 0.900010297600659 0.555555555555556 2.1 2 1 jerky movement 0.102295137239018 0.364293706345107 0.900010297600659 0.555555555555556 2.1 2 1 decreased lactate dehydrogenase level 0.102295137239018 0.364293706345107 0.900010297600659 0.555555555555556 2.1 2 1 abnormal pregnancy 0.102295137239018 0.364293706345107 0.900010297600659 0.555555555555556 2.1 2 1 abnormal macrophage chemotaxis 0.102295137239018 0.364293706345107 0.900010297600659 0.555555555555556 2.1 2 1 increased adipocyte glucose uptake 0.102295137239018 0.364293706345107 0.900010297600659 0.555555555555556 2.1 2 1 distorted hair follicle pattern 0.229462045450596 0.593333511495174 0.900010297600659 0.555555555555556 2.1 2 1 crypts of Lieberkuhn abscesses 0.229462045450596 0.593333511495174 0.900010297600659 0.555555555555556 2.1 2 1 abnormal sympathetic neuron morphology 0.229462045450596 0.593333511495174 0.900010297600659 0.555555555555556 2.1 2 1 psoriasis 0.229462045450596 0.593333511495174 0.900010297600659 0.555555555555556 2.1 2 1 abnormal kindling response 0.229462045450596 0.593333511495174 0.900010297600659 0.555555555555556 2.1 2 1 abnormal lung volume 0.229462045450596 0.593333511495174 0.900010297600659 0.555555555555556 2.1 2 1 abnormal posterior semicircular canal morphology 0.229462045450596 0.593333511495174 0.900010297600659 0.555555555555556 2.1 2 1 decreased circulating bicarbonate level 0.229462045450596 0.593333511495174 0.900010297600659 0.555555555555556 2.1 2 1 yellow coat color 0.229462045450596 0.593333511495174 0.900010297600659 0.555555555555556 2.1 2 1 abnormal abdominal wall morphology 0.229462045450596 0.593333511495174 0.900010297600659 0.555555555555556 2.1 2 1 premature neuronal precursor differentiation 0.229462045450596 0.593333511495174 0.900010297600659 0.555555555555556 2.1 2 1 decreased muscle weight 0.229462045450596 0.593333511495174 0.900010297600659 0.555555555555556 2.1 2 1 decreased cochlear hair cell number 0.229462045450596 0.593333511495174 0.900010297600659 0.555555555555556 2.1 2 1 abnormal posterior eye segment morphology 0.229462045450596 0.593333511495174 0.900010297600659 0.555555555555556 2.1 2 1 hemothorax 0.229462045450596 0.593333511495174 0.900010297600659 0.555555555555556 2.1 2 1 positive geotaxis 0.229462045450596 0.593333511495174 0.900010297600659 0.555555555555556 2.1 2 1 multiflagellated sperm 0.229462045450596 0.593333511495174 0.900010297600659 0.555555555555556 2.1 2 1 abnormal cerebellar layer morphology 0.229462045450596 0.593333511495174 0.900010297600659 0.555555555555556 2.1 2 1 retropulsion 0.229462045450596 0.593333511495174 0.900010297600659 0.555555555555556 2.1 2 1 abnormal ventricle myocardium morphology 0.229462045450596 0.593333511495174 0.900010297600659 0.555555555555556 2.1 2 1 shortened ST segment 0.229462045450596 0.593333511495174 0.900010297600659 0.555555555555556 2.1 2 1 iris coloboma 0.229462045450596 0.593333511495174 0.900010297600659 0.555555555555556 2.1 2 1 fusion of atlas and occipital bones 0.229462045450596 0.593333511495174 0.900010297600659 0.555555555555556 2.1 2 1 decreased bone trabecular spacing 0.229462045450596 0.593333511495174 0.900010297600659 0.555555555555556 2.1 2 1 abnormal coronary sinus connection 0.229462045450596 0.593333511495174 0.900010297600659 0.555555555555556 2.1 2 1 decreased hematocrit 1.59026895545328e-05 0.000298550492580379 0.898777406782028 0.554794520547945 2.1 2 1 increased sensitivity to xenobiotic induced morbidity/mortality 0.000170901205988962 0.00238464611464229 0.898373915241385 0.554545454545455 2.1 2 1 kidney cysts 0.00191926824743179 0.018326985664056 0.897577837336873 0.554054054054054 2.1 2 1 neonatal lethality, complete penetrance 7.37842488861816e-14 6.92597430582554e-12 0.895273401297498 0.552631578947368 2.1 2 1 increased circulating alanine transaminase level 0.00172161693069398 0.0168271988805551 0.893087141465269 0.551282051282051 2.1 2 1 increased circulating LDL cholesterol level 0.0118086772815677 0.0796045656853648 0.892663274763103 0.551020408163265 2.1 2 1 decreased circulating creatinine level 0.0118086772815677 0.0796045656853648 0.892663274763103 0.551020408163265 2.1 2 1 impaired ovarian folliculogenesis 0.0225266567041597 0.125639144734523 0.891010194624653 0.55 2.1 2 1 abnormal circulating enzyme level 0.0949227931385298 0.341708318280887 0.891010194624653 0.55 2.1 2 1 abnormal dopamine level 0.0949227931385298 0.341708318280887 0.891010194624653 0.55 2.1 2 1 abnormal hyoid bone morphology 0.0949227931385298 0.341708318280887 0.891010194624653 0.55 2.1 2 1 abnormal glucose homeostasis 3.09492087922754e-06 7.09549832910461e-05 0.890120074550102 0.549450549450549 2.1 2 1 increased circulating free fatty acid level 0.00300917091412112 0.0267810828224554 0.889869336500933 0.549295774647887 2.1 2 1 no abnormal phenotype detected 7.41263067293172e-48 7.37556751956706e-45 0.889843034296352 0.549279538904899 2.1 2 1 abnormal dendritic spine morphology 0.0111307347041173 0.0757529482256959 0.889421941158298 0.549019607843137 2.1 2 1 sparse hair 0.00154173605847282 0.0152668030957738 0.889034562264066 0.548780487804878 2.1 2 1 abnormal nose morphology 0.043831843185133 0.19987481195787 0.888397261502586 0.548387096774194 2.1 2 1 small cranium 0.043831843185133 0.19987481195787 0.888397261502586 0.548387096774194 2.1 2 1 decreased percent body fat/body weight 0.00284383308134999 0.0254004839851278 0.887681389414349 0.547945205479452 2.1 2 1 disheveled coat 0.0211727305794299 0.120764627197476 0.887153007634935 0.547619047619048 2.1 2 1 enlarged kidney 0.0104870394246685 0.0726643748436295 0.8864252365048 0.547169811320755 2.1 2 1 decreased circulating HDL cholesterol level 0.00010620638069658 0.00159149621676351 0.885947636700649 0.546875 2.1 2 1 abnormal lens morphology 0.00010620638069658 0.00159149621676351 0.885947636700649 0.546875 2.1 2 1 abnormal tooth development 0.0410143276589261 0.19525959818484 0.88364647400792 0.545454545454545 2.1 2 1 abnormal QRS complex 0.0410143276589261 0.19525959818484 0.88364647400792 0.545454545454545 2.1 2 1 cardiovascular system phenotype 0.0410143276589261 0.19525959818484 0.88364647400792 0.545454545454545 2.1 2 1 abnormal astrocyte morphology 0.0198922831179044 0.119233865676595 0.88364647400792 0.545454545454545 2.1 2 1 cochlear hair cell degeneration 0.0198922831179044 0.119233865676595 0.88364647400792 0.545454545454545 2.1 2 1 increased myocardial infarction size 0.0880987035286473 0.320154163663273 0.88364647400792 0.545454545454545 2.1 2 1 parakeratosis 0.0880987035286473 0.320154163663273 0.88364647400792 0.545454545454545 2.1 2 1 abnormal female reproductive system physiology 0.0880987035286473 0.320154163663273 0.88364647400792 0.545454545454545 2.1 2 1 abnormal retinal outer plexiform layer morphology 0.0880987035286473 0.320154163663273 0.88364647400792 0.545454545454545 2.1 2 1 abnormal blood-brain barrier function 0.0880987035286473 0.320154163663273 0.88364647400792 0.545454545454545 2.1 2 1 absent semicircular canals 0.207625255097459 0.549843766212157 0.88364647400792 0.545454545454545 2.1 2 1 abnormal stomach epithelium morphology 0.207625255097459 0.549843766212157 0.88364647400792 0.545454545454545 2.1 2 1 delayed hepatic development 0.207625255097459 0.549843766212157 0.88364647400792 0.545454545454545 2.1 2 1 abnormal sebaceous gland morphology 0.207625255097459 0.549843766212157 0.88364647400792 0.545454545454545 2.1 2 1 abnormal enteric ganglia morphology 0.207625255097459 0.549843766212157 0.88364647400792 0.545454545454545 2.1 2 1 abnormal glossopharyngeal ganglion morphology 0.207625255097459 0.549843766212157 0.88364647400792 0.545454545454545 2.1 2 1 abnormal food preference 0.207625255097459 0.549843766212157 0.88364647400792 0.545454545454545 2.1 2 1 impaired myelopoiesis 0.207625255097459 0.549843766212157 0.88364647400792 0.545454545454545 2.1 2 1 abnormal vestibular ganglion morphology 0.207625255097459 0.549843766212157 0.88364647400792 0.545454545454545 2.1 2 1 abnormal radial glial cell morphology 0.207625255097459 0.549843766212157 0.88364647400792 0.545454545454545 2.1 2 1 abnormal lymph circulation 0.207625255097459 0.549843766212157 0.88364647400792 0.545454545454545 2.1 2 1 abnormal pituitary gland development 0.207625255097459 0.549843766212157 0.88364647400792 0.545454545454545 2.1 2 1 abnormal coronal suture morphology 0.207625255097459 0.549843766212157 0.88364647400792 0.545454545454545 2.1 2 1 abnormal spinal cord ventral horn morphology 0.207625255097459 0.549843766212157 0.88364647400792 0.545454545454545 2.1 2 1 increased circulating triiodothyronine level 0.207625255097459 0.549843766212157 0.88364647400792 0.545454545454545 2.1 2 1 abnormal palate development 0.207625255097459 0.549843766212157 0.88364647400792 0.545454545454545 2.1 2 1 enhanced behavioral response to addictive substance 0.207625255097459 0.549843766212157 0.88364647400792 0.545454545454545 2.1 2 1 palatal shelf hypoplasia 0.207625255097459 0.549843766212157 0.88364647400792 0.545454545454545 2.1 2 1 increased subcutaneous adipose tissue amount 0.207625255097459 0.549843766212157 0.88364647400792 0.545454545454545 2.1 2 1 atrial septal defect 0.018683221206532 0.113732256893375 0.880444856348471 0.543478260869565 2.1 2 1 decreased triglyceride level 0.038369350820334 0.188735388964753 0.879438633655501 0.542857142857143 2.1 2 1 neonatal lethality, incomplete penetrance 9.85326664649382e-08 2.98902448575041e-06 0.878548513580951 0.542307692307692 2.1 2 1 infertility 0.000537594534440699 0.00626928464377208 0.878140888500082 0.542056074766355 2.1 2 1 abnormal startle reflex 0.0817899934603556 0.298975178152292 0.877510040160643 0.541666666666667 2.1 2 1 abnormal primitive streak formation 0.0817899934603556 0.298975178152292 0.877510040160643 0.541666666666667 2.1 2 1 abnormal cardiovascular system physiology 0.000130616961166249 0.00190005667193594 0.877002515556732 0.541353383458647 2.1 2 1 malocclusion 0.0358897676435505 0.179991526236556 0.875685694962803 0.540540540540541 2.1 2 1 decreased width of hypertrophic chondrocyte zone 0.0358897676435505 0.179991526236556 0.875685694962803 0.540540540540541 2.1 2 1 abnormal liver physiology 0.000924521794960023 0.00987016293975561 0.874810009267841 0.54 2.1 2 1 kidney inflammation 0.0164688471809378 0.101527279709003 0.874810009267841 0.54 2.1 2 1 skin lesions 0.00774806273817048 0.0566861942976443 0.874295717669212 0.53968253968254 2.1 2 1 increased startle reflex 0.00179039819005706 0.0174309804217884 0.873717861940415 0.539325842696629 2.1 2 1 abnormal muscle physiology 0.00179039819005706 0.0174309804217884 0.873717861940415 0.539325842696629 2.1 2 1 hyperactivity 4.66115500313633e-10 2.18766473024559e-08 0.873325356162365 0.539083557951482 2.1 2 1 abnormal xiphoid process morphology 0.0759605960883051 0.293631674855725 0.8723176730591 0.538461538461538 2.1 2 1 pulmonary edema 0.0759605960883051 0.293631674855725 0.8723176730591 0.538461538461538 2.1 2 1 abnormal renal/urinary system morphology 0.18872817460168 0.508625497639957 0.8723176730591 0.538461538461538 2.1 2 1 excessive scratching 0.18872817460168 0.508625497639957 0.8723176730591 0.538461538461538 2.1 2 1 abnormal dopaminergic neuron morphology 0.18872817460168 0.508625497639957 0.8723176730591 0.538461538461538 2.1 2 1 increased circulating thyroid-stimulating hormone level 0.18872817460168 0.508625497639957 0.8723176730591 0.538461538461538 2.1 2 1 increased circulating ammonia level 0.18872817460168 0.508625497639957 0.8723176730591 0.538461538461538 2.1 2 1 increased prostaglandin level 0.18872817460168 0.508625497639957 0.8723176730591 0.538461538461538 2.1 2 1 abnormal aorta tunica media morphology 0.18872817460168 0.508625497639957 0.8723176730591 0.538461538461538 2.1 2 1 decreased startle reflex 0.000403903117238573 0.00501101747696234 0.8723176730591 0.538461538461538 2.1 2 1 abnormal locomotor activation 0.0016881119048017 0.0165648061664467 0.8723176730591 0.538461538461538 2.1 2 1 increased urine protein level 0.00348882950944946 0.0299774210872384 0.8723176730591 0.538461538461538 2.1 2 1 hypoglycemia 0.00159140992167656 0.0156777512085958 0.870977707355477 0.537634408602151 2.1 2 1 abnormal posture 0.00328566798410756 0.0284776972490159 0.870759962928638 0.5375 2.1 2 1 abnormal retinal pigment epithelium morphology 0.00328566798410756 0.0284776972490159 0.870759962928638 0.5375 2.1 2 1 abnormal cranium morphology 0.000177545011857778 0.00244001777345979 0.870457720664518 0.537313432835821 2.1 2 1 maternal effect 0.00685377811894176 0.0524744103453112 0.870457720664518 0.537313432835821 2.1 2 1 weight loss 2.05357309326548e-05 0.000374231726703141 0.87018138488018 0.537142857142857 2.1 2 1 impaired limb coordination 0.014506700458718 0.0904985529146495 0.870009954347304 0.537037037037037 2.1 2 1 postnatal lethality, incomplete penetrance 2.82756249483966e-14 2.70521604073602e-12 0.869904319335848 0.536971830985915 2.1 2 1 respiratory failure 7.84151085582765e-05 0.00121153777974356 0.869016565497855 0.536423841059603 2.1 2 1 myoclonus 0.0705743325414033 0.286878659400099 0.86786707268635 0.535714285714286 2.1 2 1 abnormal renal tubule epithelium morphology 0.0705743325414033 0.286878659400099 0.86786707268635 0.535714285714286 2.1 2 1 impaired macrophage phagocytosis 0.0293618670250026 0.156063342360457 0.8665215423411 0.534883720930233 2.1 2 1 decreased oxygen consumption 0.0293618670250026 0.156063342360457 0.8665215423411 0.534883720930233 2.1 2 1 impaired coordination 4.73587168993613e-09 1.97991274432204e-07 0.866194881794854 0.534682080924855 2.1 2 1 abnormal pulmonary alveolus morphology 0.00125516704117336 0.0127960164545849 0.866148524027565 0.534653465346535 2.1 2 1 hyperglycemia 0.00258106582645677 0.0237792638641156 0.865237172466088 0.534090909090909 2.1 2 1 thin ventricular wall 0.00242923785507721 0.0228481221341993 0.864009885696633 0.533333333333333 2.1 2 1 delayed bone ossification 0.00535434903197366 0.0425525342397268 0.864009885696633 0.533333333333333 2.1 2 1 abnormal enteric neuron morphology 0.172162792407805 0.469835376976869 0.864009885696633 0.533333333333333 2.1 2 1 vagina atresia 0.172162792407805 0.469835376976869 0.864009885696633 0.533333333333333 2.1 2 1 hyperpigmentation 0.172162792407805 0.469835376976869 0.864009885696633 0.533333333333333 2.1 2 1 abnormal epidermis stratum spinosum morphology 0.172162792407805 0.469835376976869 0.864009885696633 0.533333333333333 2.1 2 1 arthritis 0.172162792407805 0.469835376976869 0.864009885696633 0.533333333333333 2.1 2 1 abnormal pericyte morphology 0.172162792407805 0.469835376976869 0.864009885696633 0.533333333333333 2.1 2 1 abnormal olfactory nerve morphology 0.172162792407805 0.469835376976869 0.864009885696633 0.533333333333333 2.1 2 1 abnormal zygomatic bone morphology 0.172162792407805 0.469835376976869 0.864009885696633 0.533333333333333 2.1 2 1 abnormal cerebral aqueduct morphology 0.172162792407805 0.469835376976869 0.864009885696633 0.533333333333333 2.1 2 1 abnormal coronary vessel morphology 0.172162792407805 0.469835376976869 0.864009885696633 0.533333333333333 2.1 2 1 hypoactivity 1.43348219149623e-09 6.36747669883371e-08 0.863723410270341 0.53315649867374 2.1 2 1 impaired glucose tolerance 9.76545159503799e-07 2.49144213770841e-05 0.862267930281922 0.532258064516129 2.1 2 1 abnormal crypts of Lieberkuhn morphology 0.0609941789533213 0.255425959842402 0.86063484708063 0.53125 2.1 2 1 polydipsia 0.0609941789533213 0.255425959842402 0.86063484708063 0.53125 2.1 2 1 abnormal lumbar vertebrae morphology 0.0609941789533213 0.255425959842402 0.86063484708063 0.53125 2.1 2 1 decreased susceptibility to parasitic infection 0.0609941789533213 0.255425959842402 0.86063484708063 0.53125 2.1 2 1 postnatal lethality 6.99799784174431e-05 0.00108796997695869 0.858805006867135 0.530120481927711 2.1 2 1 abnormal lung development 0.00392538473074644 0.0330436362698199 0.857656871831216 0.529411764705882 2.1 2 1 abnormal retinal photoreceptor morphology 0.056737274171087 0.240466405190132 0.857656871831216 0.529411764705882 2.1 2 1 abnormal skin physiology 0.056737274171087 0.240466405190132 0.857656871831216 0.529411764705882 2.1 2 1 increased incidence of corneal inflammation 0.15750187564236 0.438948026086241 0.857656871831216 0.529411764705882 2.1 2 1 abnormal touch/ nociception 0.15750187564236 0.438948026086241 0.857656871831216 0.529411764705882 2.1 2 1 abnormal cranial suture morphology 0.15750187564236 0.438948026086241 0.857656871831216 0.529411764705882 2.1 2 1 abnormal duodenum morphology 0.15750187564236 0.438948026086241 0.857656871831216 0.529411764705882 2.1 2 1 abnormal testis development 0.15750187564236 0.438948026086241 0.857656871831216 0.529411764705882 2.1 2 1 increased trabecular bone mass 0.15750187564236 0.438948026086241 0.857656871831216 0.529411764705882 2.1 2 1 abnormal electroretinogram waveform feature 0.15750187564236 0.438948026086241 0.857656871831216 0.529411764705882 2.1 2 1 delayed heart development 0.15750187564236 0.438948026086241 0.857656871831216 0.529411764705882 2.1 2 1 abnormal cervical vertebrae morphology 0.0224742237173608 0.125628385386371 0.857656871831216 0.529411764705882 2.1 2 1 small lung 0.0224742237173608 0.125628385386371 0.857656871831216 0.529411764705882 2.1 2 1 abnormal thrombosis 0.0224742237173608 0.125628385386371 0.857656871831216 0.529411764705882 2.1 2 1 abnormal neuromuscular synapse morphology 0.00816804779438665 0.057886093699535 0.855009782720626 0.527777777777778 2.1 2 1 reduced long term depression 0.0527977766888413 0.236391528085669 0.855009782720626 0.527777777777778 2.1 2 1 narrow eye opening 0.0527977766888413 0.236391528085669 0.855009782720626 0.527777777777778 2.1 2 1 abnormal frontal bone morphology 0.049150072334341 0.222494640458004 0.852641334569045 0.526315789473684 2.1 2 1 abnormal compact bone morphology 0.049150072334341 0.222494640458004 0.852641334569045 0.526315789473684 2.1 2 1 short vibrissae 0.144430451826456 0.436941280948118 0.852641334569045 0.526315789473684 2.1 2 1 unresponsive to tactile stimuli 0.144430451826456 0.436941280948118 0.852641334569045 0.526315789473684 2.1 2 1 decreased germ cell number 0.144430451826456 0.436941280948118 0.852641334569045 0.526315789473684 2.1 2 1 abnormal nasal septum morphology 0.144430451826456 0.436941280948118 0.852641334569045 0.526315789473684 2.1 2 1 abnormal metatarsal bone morphology 0.144430451826456 0.436941280948118 0.852641334569045 0.526315789473684 2.1 2 1 abnormal digestive system development 0.144430451826456 0.436941280948118 0.852641334569045 0.526315789473684 2.1 2 1 increased left ventricle weight 0.144430451826456 0.436941280948118 0.852641334569045 0.526315789473684 2.1 2 1 absent amnion 0.144430451826456 0.436941280948118 0.852641334569045 0.526315789473684 2.1 2 1 thin interventricular septum 0.144430451826456 0.436941280948118 0.852641334569045 0.526315789473684 2.1 2 1 abnormal cornea morphology 0.00674335537696286 0.05177190277838 0.851548204652931 0.525641025641026 2.1 2 1 abnormal thoracic vertebrae morphology 0.0172234527145714 0.10578602130246 0.851196179764691 0.525423728813559 2.1 2 1 abnormal pancreatic beta cell morphology 0.0457707275172022 0.20795376200738 0.850509731232623 0.525 2.1 2 1 ataxia 2.40965789228816e-05 0.000426620925769879 0.850108736545573 0.524752475247525 2.1 2 1 abnormal long bone morphology 0.0161187579769281 0.0996159266275992 0.849845789209803 0.524590163934426 2.1 2 1 abnormal hair follicle morphology 0.0150864066461912 0.0935846297566101 0.848581137737764 0.523809523809524 2.1 2 1 decreased cochlear outer hair cell number 0.132707720468897 0.436941280948118 0.848581137737764 0.523809523809524 2.1 2 1 abnormal stapes morphology 0.132707720468897 0.436941280948118 0.848581137737764 0.523809523809524 2.1 2 1 abnormal tumor vascularization 0.132707720468897 0.436941280948118 0.848581137737764 0.523809523809524 2.1 2 1 complete atrioventricular septal defect 0.132707720468897 0.436941280948118 0.848581137737764 0.523809523809524 2.1 2 1 vascular ring 0.132707720468897 0.436941280948118 0.848581137737764 0.523809523809524 2.1 2 1 decreased sensitivity to induced morbidity/mortality 0.0397333160661099 0.190253366149083 0.846827870924256 0.522727272727273 2.1 2 1 increased or absent threshold for auditory brainstem response 7.38260871790667e-07 1.93307780903083e-05 0.846445670892246 0.522491349480969 2.1 2 1 increased bone mineral density 0.00163999178474533 0.01612442515634 0.845850385886637 0.52212389380531 2.1 2 1 hyperkeratosis 0.0123767768540075 0.0823188032736461 0.845227062094532 0.521739130434783 2.1 2 1 abnormal inner ear morphology 0.0370378215969358 0.185003175145337 0.845227062094532 0.521739130434783 2.1 2 1 bidirectional circling 0.122144296836182 0.424942571160842 0.845227062094532 0.521739130434783 2.1 2 1 abnormal corneal stroma morphology 0.122144296836182 0.424942571160842 0.845227062094532 0.521739130434783 2.1 2 1 abnormal osteoclast morphology 0.0345355158447209 0.173748704180456 0.843759654000618 0.520833333333333 2.1 2 1 respiratory distress 0.000141970812239404 0.00204726026345228 0.842784209313912 0.520231213872832 2.1 2 1 increased body length 0.0322114663416555 0.168011159193582 0.842409638554217 0.52 2.1 2 1 increased circulating chloride level 0.0322114663416555 0.168011159193582 0.842409638554217 0.52 2.1 2 1 abnormal thyroid gland morphology 0.112587826408419 0.395288945929348 0.842409638554217 0.52 2.1 2 1 decreased acute inflammation 0.112587826408419 0.395288945929348 0.842409638554217 0.52 2.1 2 1 abnormal vertebrae development 0.112587826408419 0.395288945929348 0.842409638554217 0.52 2.1 2 1 increased liver glycogen level 0.112587826408419 0.395288945929348 0.842409638554217 0.52 2.1 2 1 eyelids open at birth 0.030052007921592 0.159051850436085 0.841163470449847 0.519230769230769 2.1 2 1 abnormal skeleton development 0.00835197900790375 0.0589377242047109 0.840009611093948 0.518518518518518 2.1 2 1 abnormal atrioventricular cushion morphology 0.103913467891402 0.369000358857761 0.840009611093948 0.518518518518518 2.1 2 1 rectal prolapse 0.103913467891402 0.369000358857761 0.840009611093948 0.518518518518518 2.1 2 1 cryptorchism 0.103913467891402 0.369000358857761 0.840009611093948 0.518518518518518 2.1 2 1 abnormal skin appearance 0.103913467891402 0.369000358857761 0.840009611093948 0.518518518518518 2.1 2 1 abnormal seminal vesicle morphology 0.0261778447145694 0.140188135043039 0.838938170263471 0.517857142857143 2.1 2 1 abnormal gait 7.28123682416686e-07 1.91662186244604e-05 0.838844549220032 0.517799352750809 2.1 2 1 short limbs 0.0068693663398004 0.0524963095860322 0.837940621904062 0.517241379310345 2.1 2 1 abnormal eating behavior 0.0228248498651261 0.126170697865558 0.837009576768613 0.516666666666667 2.1 2 1 abnormal long bone epiphyseal plate morphology 0.0228248498651261 0.126170697865558 0.837009576768613 0.516666666666667 2.1 2 1 abnormal podocyte morphology 0.0888119735741837 0.322275396448989 0.836138599061257 0.516129032258065 2.1 2 1 abnormal intestinal goblet cell morphology 0.0761856636012954 0.293996796249452 0.833152389778896 0.514285714285714 2.1 2 1 increased white adipose tissue amount 0.070645119569981 0.286878659400099 0.831901410214663 0.513513513513513 2.1 2 1 abnormal breathing pattern 0.070645119569981 0.286878659400099 0.831901410214663 0.513513513513513 2.1 2 1 abnormal hair follicle development 0.070645119569981 0.286878659400099 0.831901410214663 0.513513513513513 2.1 2 1 abnormal heart looping 0.0655526849595899 0.270642827945195 0.830778736246762 0.512820512820513 2.1 2 1 acanthosis 0.0655526849595899 0.270642827945195 0.830778736246762 0.512820512820513 2.1 2 1 increased vascular permeability 0.0655526849595899 0.270642827945195 0.830778736246762 0.512820512820513 2.1 2 1 abnormal circulating hormone level 0.0655526849595899 0.270642827945195 0.830778736246762 0.512820512820513 2.1 2 1 decreased anxiety-related response 0.00215724946503615 0.0205206808576574 0.829765591446461 0.51219512195122 2.1 2 1 palatal shelves fail to meet at midline 0.0608658252515419 0.255425959842402 0.829765591446461 0.51219512195122 2.1 2 1 increased circulating cholesterol level 0.000306807125445351 0.00394409676767602 0.828418569382425 0.511363636363636 2.1 2 1 albuminuria 0.0525629332241033 0.236391528085669 0.828009473792606 0.511111111111111 2.1 2 1 abnormal tibia morphology 0.048883979444574 0.221693525739978 0.827243507581882 0.51063829787234 2.1 2 1 abnormal long bone hypertrophic chondrocyte zone 0.0454836527891358 0.20683836620288 0.826540069225095 0.510204081632653 2.1 2 1 decreased heart rate 0.0060223024901176 0.0474817034680429 0.826209453197405 0.51 2.1 2 1 distended abdomen 0.0423381986709222 0.197036986330999 0.825891802504134 0.509803921568627 2.1 2 1 short snout 0.00464145299730159 0.0373644476724521 0.825009439467271 0.509259259259259 2.1 2 1 seizures 0.00382153874494746 0.032388680163737 0.824219956750077 0.508771929824561 2.1 2 1 abnormal circulating amino acid level 0.0342276193866603 0.172525234497097 0.824219956750077 0.508771929824561 2.1 2 1 increased hemoglobin content 0.031907716107011 0.168011159193582 0.823738238481959 0.508474576271186 2.1 2 1 abnormal skeletal muscle fiber morphology 0.0210694573187994 0.120764627197476 0.821417849077785 0.507042253521127 2.1 2 1 abnormal neurocranium morphology 0.0183836834919125 0.112423834099949 0.820809391411801 0.506666666666667 2.1 2 1 hunched posture 0.0160537187938605 0.0993373768649949 0.820262549711993 0.506329113924051 2.1 2 1 abnormal myocardial fiber morphology 0.00879947833372917 0.0616196823999027 0.818359878849259 0.505154639175258 2.1 2 1 abnormal renal glomerulus morphology 0.00593049362620824 0.0468320726831524 0.817440545527204 0.504587155963303 2.1 2 1 abnormal myelin sheath morphology 0.0680880448512712 0.278910632373359 0.810009267840593 0.5 2.1 2 1 decreased circulating phosphate level 0.0853346424019774 0.311474575164958 0.810009267840593 0.5 2.1 2 1 perinatal lethality 0.0853346424019774 0.311474575164958 0.810009267840593 0.5 2.1 2 1 increased width of hypertrophic chondrocyte zone 0.107708267736145 0.382203018535892 0.810009267840593 0.5 2.1 2 1 abnormal postnatal subventricular zone morphology 0.193938110514382 0.520599553029526 0.810009267840593 0.5 2.1 2 1 abnormal incus morphology 0.193938110514382 0.520599553029526 0.810009267840593 0.5 2.1 2 1 abnormal response to tactile stimuli 0.193938110514382 0.520599553029526 0.810009267840593 0.5 2.1 2 1 fused cornea and lens 0.321710788354967 0.675744316057538 0.810009267840593 0.5 2.1 2 1 decreased incidence of induced tumors 0.321710788354967 0.675744316057538 0.810009267840593 0.5 2.1 2 1 abnormal gland morphology 0.321710788354967 0.675744316057538 0.810009267840593 0.5 2.1 2 1 abnormal PNS synaptic transmission 0.321710788354967 0.675744316057538 0.810009267840593 0.5 2.1 2 1 abnormal primordial germ cell migration 0.321710788354967 0.675744316057538 0.810009267840593 0.5 2.1 2 1 increased natural killer cell mediated cytotoxicity 0.321710788354967 0.675744316057538 0.810009267840593 0.5 2.1 2 1 abnormal tibialis anterior morphology 0.321710788354967 0.675744316057538 0.810009267840593 0.5 2.1 2 1 rickets 0.321710788354967 0.675744316057538 0.810009267840593 0.5 2.1 2 1 peritoneal inflammation 0.321710788354967 0.675744316057538 0.810009267840593 0.5 2.1 2 1 increased left ventricle diastolic pressure 0.321710788354967 0.675744316057538 0.810009267840593 0.5 2.1 2 1 abnormal ear physiology 0.321710788354967 0.675744316057538 0.810009267840593 0.5 2.1 2 1 abnormal plasma membrane morphology 0.321710788354967 0.675744316057538 0.810009267840593 0.5 2.1 2 1 abnormal embryonic erythrocyte morphology 0.321710788354967 0.675744316057538 0.810009267840593 0.5 2.1 2 1 abnormal deltoid tuberosity morphology 0.321710788354967 0.675744316057538 0.810009267840593 0.5 2.1 2 1 abnormal respiratory conducting tube morphology 0.321710788354967 0.675744316057538 0.810009267840593 0.5 2.1 2 1 abnormal cochlear inner hair cell physiology 0.321710788354967 0.675744316057538 0.810009267840593 0.5 2.1 2 1 absent coat pigmentation 0.321710788354967 0.675744316057538 0.810009267840593 0.5 2.1 2 1 abnormal gonadal fat pad morphology 0.321710788354967 0.675744316057538 0.810009267840593 0.5 2.1 2 1 abnormal cerebellar granule cell migration 0.321710788354967 0.675744316057538 0.810009267840593 0.5 2.1 2 1 increased serotonin level 0.321710788354967 0.675744316057538 0.810009267840593 0.5 2.1 2 1 umbilical hernia 0.321710788354967 0.675744316057538 0.810009267840593 0.5 2.1 2 1 increased T-helper 17 cell number 0.321710788354967 0.675744316057538 0.810009267840593 0.5 2.1 2 1 abnormal circadian temperature homeostasis 0.321710788354967 0.675744316057538 0.810009267840593 0.5 2.1 2 1 decreased macrophage cytokine production 0.321710788354967 0.675744316057538 0.810009267840593 0.5 2.1 2 1 improved glucose tolerance 0.000477866610597554 0.00574247919739815 0.810009267840593 0.5 2.1 2 1 cyanosis 0.000541992802072302 0.00626928464377208 0.810009267840593 0.5 2.1 2 1 abnormal suckling behavior 0.0156104169689135 0.096714600772534 0.810009267840593 0.5 2.1 2 1 increased circulating creatinine level 0.0166997646961063 0.102696328013756 0.810009267840593 0.5 2.1 2 1 absent gastric milk in neonates 0.0219155060165728 0.123197336081864 0.810009267840593 0.5 2.1 2 1 increased susceptibility to bacterial infection induced morbidity/mortality 0.0269341348502459 0.144083140731154 0.810009267840593 0.5 2.1 2 1 abnormal incisor morphology 0.040990582348896 0.19525959818484 0.810009267840593 0.5 2.1 2 1 abnormal enzyme/coenzyme level 0.044014097272635 0.200522100669743 0.810009267840593 0.5 2.1 2 1 abnormal skin condition 0.0546243894202521 0.236391528085669 0.810009267840593 0.5 2.1 2 1 abnormal brain wave pattern 0.0546243894202521 0.236391528085669 0.810009267840593 0.5 2.1 2 1 abnormal intestinal epithelium morphology 0.0632324430444267 0.264354121131112 0.810009267840593 0.5 2.1 2 1 increased grooming behavior 0.092140166805621 0.333622510813657 0.810009267840593 0.5 2.1 2 1 kidney cortex cysts 0.116629768195046 0.408327302442193 0.810009267840593 0.5 2.1 2 1 abnormal response to new environment 0.126438291369268 0.436941280948118 0.810009267840593 0.5 2.1 2 1 disorganized myocardium 0.126438291369268 0.436941280948118 0.810009267840593 0.5 2.1 2 1 abnormal Schwann cell morphology 0.149215056728534 0.438948026086241 0.810009267840593 0.5 2.1 2 1 small seminal vesicle 0.149215056728534 0.438948026086241 0.810009267840593 0.5 2.1 2 1 no spontaneous movement 0.149215056728534 0.438948026086241 0.810009267840593 0.5 2.1 2 1 decreased body height 0.162498600212007 0.447388232459732 0.810009267840593 0.5 2.1 2 1 abnormal body weight 0.162498600212007 0.447388232459732 0.810009267840593 0.5 2.1 2 1 decreased metastatic potential 0.162498600212007 0.447388232459732 0.810009267840593 0.5 2.1 2 1 abnormal vasodilation 0.162498600212007 0.447388232459732 0.810009267840593 0.5 2.1 2 1 abnormal impulse conducting system conduction 0.162498600212007 0.447388232459732 0.810009267840593 0.5 2.1 2 1 prolonged QT interval 0.162498600212007 0.447388232459732 0.810009267840593 0.5 2.1 2 1 hypopigmentation 0.162498600212007 0.447388232459732 0.810009267840593 0.5 2.1 2 1 abnormal long bone epiphysis morphology 0.177316737409148 0.480736113684202 0.810009267840593 0.5 2.1 2 1 abnormal vascular branching morphogenesis 0.177316737409148 0.480736113684202 0.810009267840593 0.5 2.1 2 1 prolonged PR interval 0.177316737409148 0.480736113684202 0.810009267840593 0.5 2.1 2 1 decreased circulating estradiol level 0.177316737409148 0.480736113684202 0.810009267840593 0.5 2.1 2 1 pulmonary vascular congestion 0.177316737409148 0.480736113684202 0.810009267840593 0.5 2.1 2 1 increased circulating creatine kinase level 0.177316737409148 0.480736113684202 0.810009267840593 0.5 2.1 2 1 rough coat 0.177316737409148 0.480736113684202 0.810009267840593 0.5 2.1 2 1 thick dermal layer 0.212708614045701 0.559611504430124 0.810009267840593 0.5 2.1 2 1 blepharoptosis 0.212708614045701 0.559611504430124 0.810009267840593 0.5 2.1 2 1 abnormal iron level 0.212708614045701 0.559611504430124 0.810009267840593 0.5 2.1 2 1 abnormal thyroid cartilage morphology 0.212708614045701 0.559611504430124 0.810009267840593 0.5 2.1 2 1 abnormal white adipose tissue morphology 0.212708614045701 0.559611504430124 0.810009267840593 0.5 2.1 2 1 absent allantois 0.212708614045701 0.559611504430124 0.810009267840593 0.5 2.1 2 1 increased circulating glycerol level 0.212708614045701 0.559611504430124 0.810009267840593 0.5 2.1 2 1 abnormal eye anterior chamber morphology 0.212708614045701 0.559611504430124 0.810009267840593 0.5 2.1 2 1 abnormal glycogen homeostasis 0.212708614045701 0.559611504430124 0.810009267840593 0.5 2.1 2 1 abnormal tympanic ring morphology 0.23408635564681 0.602161126857744 0.810009267840593 0.5 2.1 2 1 delayed hair appearance 0.23408635564681 0.602161126857744 0.810009267840593 0.5 2.1 2 1 abnormal mouth morphology 0.23408635564681 0.602161126857744 0.810009267840593 0.5 2.1 2 1 reduced male mating frequency 0.23408635564681 0.602161126857744 0.810009267840593 0.5 2.1 2 1 poor circulation 0.23408635564681 0.602161126857744 0.810009267840593 0.5 2.1 2 1 decreased creatinine clearance 0.23408635564681 0.602161126857744 0.810009267840593 0.5 2.1 2 1 increased heart left ventricle size 0.23408635564681 0.602161126857744 0.810009267840593 0.5 2.1 2 1 decreased adipocyte glucose uptake 0.23408635564681 0.602161126857744 0.810009267840593 0.5 2.1 2 1 amyloidosis 0.287450590644649 0.675744316057538 0.810009267840593 0.5 2.1 2 1 mesocardia 0.287450590644649 0.675744316057538 0.810009267840593 0.5 2.1 2 1 abnormal enteric nervous system morphology 0.287450590644649 0.675744316057538 0.810009267840593 0.5 2.1 2 1 impaired embryo implantation 0.287450590644649 0.675744316057538 0.810009267840593 0.5 2.1 2 1 abnormal tracheal ciliated epithelium morphology 0.287450590644649 0.675744316057538 0.810009267840593 0.5 2.1 2 1 abnormal corticospinal tract morphology 0.287450590644649 0.675744316057538 0.810009267840593 0.5 2.1 2 1 increased circulating parathyroid hormone level 0.287450590644649 0.675744316057538 0.810009267840593 0.5 2.1 2 1 small thyroid gland 0.287450590644649 0.675744316057538 0.810009267840593 0.5 2.1 2 1 dilated bile duct 0.287450590644649 0.675744316057538 0.810009267840593 0.5 2.1 2 1 absent tail 0.287450590644649 0.675744316057538 0.810009267840593 0.5 2.1 2 1 increased fear-related response 0.287450590644649 0.675744316057538 0.810009267840593 0.5 2.1 2 1 delayed somite formation 0.287450590644649 0.675744316057538 0.810009267840593 0.5 2.1 2 1 abnormal nucleotide metabolism 0.287450590644649 0.675744316057538 0.810009267840593 0.5 2.1 2 1 bowed ulna 0.287450590644649 0.675744316057538 0.810009267840593 0.5 2.1 2 1 decreased keratinocyte proliferation 0.287450590644649 0.675744316057538 0.810009267840593 0.5 2.1 2 1 decreased oligodendrocyte number 0.287450590644649 0.675744316057538 0.810009267840593 0.5 2.1 2 1 decreased prostaglandin level 0.287450590644649 0.675744316057538 0.810009267840593 0.5 2.1 2 1 increased total body fat amount 0.00343735389357053 0.0297405836878493 0.810009267840593 0.5 2.1 2 1 reddish skin 0.1372526032414 0.436941280948118 0.810009267840593 0.5 2.1 2 1 abnormal retinal inner nuclear layer morphology 0.1372526032414 0.436941280948118 0.810009267840593 0.5 2.1 2 1 corneal vascularization 0.1372526032414 0.436941280948118 0.810009267840593 0.5 2.1 2 1 prolonged QRS complex duration 0.1372526032414 0.436941280948118 0.810009267840593 0.5 2.1 2 1 abnormal blood flow velocity 0.258699787730018 0.646424632826137 0.810009267840593 0.5 2.1 2 1 abnormal kidney blood vessel morphology 0.258699787730018 0.646424632826137 0.810009267840593 0.5 2.1 2 1 translucent skin 0.258699787730018 0.646424632826137 0.810009267840593 0.5 2.1 2 1 irregularly shaped pupil 0.258699787730018 0.646424632826137 0.810009267840593 0.5 2.1 2 1 increased aggression towards males 0.258699787730018 0.646424632826137 0.810009267840593 0.5 2.1 2 1 extended life span 0.258699787730018 0.646424632826137 0.810009267840593 0.5 2.1 2 1 absent visceral yolk sac blood islands 0.258699787730018 0.646424632826137 0.810009267840593 0.5 2.1 2 1 decreased vascular permeability 0.258699787730018 0.646424632826137 0.810009267840593 0.5 2.1 2 1 intestinal obstruction 0.258699787730018 0.646424632826137 0.810009267840593 0.5 2.1 2 1 increased B-1 B cell number 0.258699787730018 0.646424632826137 0.810009267840593 0.5 2.1 2 1 decreased CNS synapse formation 0.258699787730018 0.646424632826137 0.810009267840593 0.5 2.1 2 1 premature hair loss 0.258699787730018 0.646424632826137 0.810009267840593 0.5 2.1 2 1 pulmonary alveolar hemorrhage 0.258699787730018 0.646424632826137 0.810009267840593 0.5 2.1 2 1 abnormal renal tubule epithelial cell primary cilium morphology 0.258699787730018 0.646424632826137 0.810009267840593 0.5 2.1 2 1 increased circulating glucose level 0.00354896694258017 0.0302853437487219 0.804264521260163 0.49645390070922 2.1 2 1 abnormal trabecular bone morphology 0.00725181962543781 0.0547462862466663 0.803202467270504 0.495798319327731 2.1 2 1 cardiac fibrosis 0.0225074444994372 0.125639144734523 0.800479747042468 0.494117647058824 2.1 2 1 abnormal myocardium layer morphology 0.0276307485587172 0.147650885155336 0.799755985969193 0.493670886075949 2.1 2 1 decreased liver weight 0.0364444227390776 0.182589127016023 0.798600686603402 0.492957746478873 2.1 2 1 abnormal contextual conditioning behavior 0.0643843824928795 0.266926919085063 0.795281826607128 0.490909090909091 2.1 2 1 abnormal joint morphology 0.0643843824928795 0.266926919085063 0.795281826607128 0.490909090909091 2.1 2 1 abnormal spatial learning 0.00287574904034755 0.025639518773708 0.795101121806717 0.49079754601227 2.1 2 1 impaired balance 0.0163661739075713 0.10101949775455 0.794126733177052 0.490196078431373 2.1 2 1 abnormal epidermis stratum corneum morphology 0.0802712816895065 0.293996796249452 0.793478466456091 0.489795918367347 2.1 2 1 increased fluid intake 0.0802712816895065 0.293996796249452 0.793478466456091 0.489795918367347 2.1 2 1 increased circulating triglyceride level 0.00512059720118011 0.0409565451380564 0.793250455402512 0.489655172413793 2.1 2 1 increased sensitivity to induced morbidity/mortality 0.00187510730331058 0.0179397285268656 0.792400370713624 0.489130434782609 2.1 2 1 altered response to myocardial infarction 0.0932541955494022 0.336431923755095 0.79200906188858 0.488888888888889 2.1 2 1 irregular heartbeat 0.0932541955494022 0.336431923755095 0.79200906188858 0.488888888888889 2.1 2 1 abnormal metabolism 0.0932541955494022 0.336431923755095 0.79200906188858 0.488888888888889 2.1 2 1 cardiomyopathy 0.0932541955494022 0.336431923755095 0.79200906188858 0.488888888888889 2.1 2 1 abnormal homeostasis 0.100614808168025 0.361675340054858 0.791171843007091 0.488372093023256 2.1 2 1 kidney failure 0.100614808168025 0.361675340054858 0.791171843007091 0.488372093023256 2.1 2 1 decreased exploration in new environment 0.0300310365569406 0.159051850436085 0.790723332892008 0.488095238095238 2.1 2 1 decreased inflammatory response 0.0300310365569406 0.159051850436085 0.790723332892008 0.488095238095238 2.1 2 1 lethality at weaning, incomplete penetrance 0.108638277783345 0.384954011376168 0.790252944234725 0.48780487804878 2.1 2 1 increased circulating insulin level 0.00401871136226382 0.0337721098433488 0.789759036144578 0.4875 2.1 2 1 increased brown adipose tissue amount 0.126979432460478 0.436941280948118 0.788117125466523 0.486486486486487 2.1 2 1 abnormal kidney morphology 0.00315108125355292 0.0274546921828823 0.786866145902291 0.485714285714286 2.1 2 1 thick epidermis 0.0487340790750578 0.221215368064245 0.78686614590229 0.485714285714286 2.1 2 1 thick pulmonary interalveolar septum 0.137479616085726 0.436941280948118 0.78686614590229 0.485714285714286 2.1 2 1 impaired adaptive thermogenesis 0.137479616085726 0.436941280948118 0.78686614590229 0.485714285714286 2.1 2 1 abnormal motor capabilities/coordination/movement 0.00988699628240918 0.0686022405927276 0.785463532451484 0.484848484848485 2.1 2 1 abnormal epidermis stratum basale morphology 0.149012824422275 0.438948026086241 0.785463532451484 0.484848484848485 2.1 2 1 abnormal skeleton physiology 0.149012824422275 0.438948026086241 0.785463532451484 0.484848484848485 2.1 2 1 decreased sensitivity to xenobiotic induced morbidity/mortality 0.149012824422275 0.438948026086241 0.785463532451484 0.484848484848485 2.1 2 1 abnormal tooth morphology 0.0602325716664185 0.254162039050409 0.784696478220575 0.484375 2.1 2 1 lethargy 0.0282478795924849 0.150786696322546 0.783879936619929 0.483870967741935 2.1 2 1 pale kidney 0.161712964302159 0.446956665224021 0.783879936619929 0.483870967741935 2.1 2 1 abnormal eye physiology 0.0694931953498803 0.283849463764905 0.783008958912573 0.483333333333333 2.1 2 1 increased blood urea nitrogen level 0.008194608883172 0.0579917200480522 0.782077913777124 0.482758620689655 2.1 2 1 decreased retinal photoreceptor cell number 0.175738833171748 0.478282655924205 0.782077913777124 0.482758620689655 2.1 2 1 increased susceptibility to induced arthritis 0.175738833171748 0.478282655924205 0.782077913777124 0.482758620689655 2.1 2 1 enlarged epididymis 0.175738833171748 0.478282655924205 0.782077913777124 0.482758620689655 2.1 2 1 increased retinal apoptosis 0.175738833171748 0.478282655924205 0.782077913777124 0.482758620689655 2.1 2 1 enhanced long term potentiation 0.0803098786136693 0.293996796249452 0.781080365417715 0.482142857142857 2.1 2 1 abnormal trigeminal nerve morphology 0.191280817791586 0.514390307304401 0.780008924587238 0.481481481481481 2.1 2 1 abnormal palate morphology 0.191280817791586 0.514390307304401 0.780008924587238 0.481481481481481 2.1 2 1 thick interventricular septum 0.191280817791586 0.514390307304401 0.780008924587238 0.481481481481481 2.1 2 1 increased exploration in new environment 0.0424689701910427 0.197460866075175 0.780008924587238 0.481481481481481 2.1 2 1 decreased body temperature 0.0929842938178673 0.336431923755095 0.77885506523134 0.480769230769231 2.1 2 1 abnormal kidney physiology 0.10789067886189 0.382577425044836 0.776258881680568 0.479166666666667 2.1 2 1 corneal opacity 0.0600272767892008 0.253510782704817 0.775783524129019 0.47887323943662 2.1 2 1 cleft secondary palate 0.0345401946601951 0.173748704180456 0.775540788358015 0.478723404255319 2.1 2 1 abnormal locomotor behavior 0.0369397666140384 0.184698833070192 0.774791473586654 0.478260869565217 2.1 2 1 abnormal sleep pattern 0.116323167022689 0.407540673195689 0.774791473586654 0.478260869565217 2.1 2 1 abnormal pulmonary artery morphology 0.227891474601033 0.593333511495174 0.774791473586654 0.478260869565217 2.1 2 1 abnormal circulating insulin level 0.227891474601033 0.593333511495174 0.774791473586654 0.478260869565217 2.1 2 1 abnormal postnatal growth 0.227891474601033 0.593333511495174 0.774791473586654 0.478260869565217 2.1 2 1 abnormal cochlear ganglion morphology 0.227891474601033 0.593333511495174 0.774791473586654 0.478260869565217 2.1 2 1 hypertension 0.125499003451972 0.435699610728236 0.77319066475693 0.477272727272727 2.1 2 1 renal interstitial fibrosis 0.125499003451972 0.435699610728236 0.77319066475693 0.477272727272727 2.1 2 1 decreased monocyte cell number 0.0741289834310784 0.288343778396884 0.772624224709489 0.476923076923077 2.1 2 1 abnormal muscle morphology 0.135497328656374 0.436941280948118 0.771437397943422 0.476190476190476 2.1 2 1 abnormal scapula morphology 0.249602101464824 0.638770810075874 0.771437397943422 0.476190476190476 2.1 2 1 increased vasoconstriction 0.249602101464824 0.638770810075874 0.771437397943422 0.476190476190476 2.1 2 1 increased bone ossification 0.249602101464824 0.638770810075874 0.771437397943422 0.476190476190476 2.1 2 1 abnormal maternal nurturing 0.0854694437717509 0.31173789058978 0.770172746471384 0.475409836065574 2.1 2 1 deafness 0.0366465367381282 0.183417022406628 0.769099708858745 0.474747474747475 2.1 2 1 postnatal lethality, complete penetrance 0.000123319168781329 0.00180977246220387 0.7680398757245 0.474093264248705 2.1 2 1 abnormal retinal outer nuclear layer morphology 0.15833477154985 0.438948026086241 0.767377201112141 0.473684210526316 2.1 2 1 hyporesponsive to tactile stimuli 0.15833477154985 0.438948026086241 0.767377201112141 0.473684210526316 2.1 2 1 abnormal triglyceride level 0.274158960043022 0.675744316057538 0.767377201112141 0.473684210526316 2.1 2 1 shiny skin 0.274158960043022 0.675744316057538 0.767377201112141 0.473684210526316 2.1 2 1 thin dermal layer 0.274158960043022 0.675744316057538 0.767377201112141 0.473684210526316 2.1 2 1 altered susceptibility to infection 0.274158960043022 0.675744316057538 0.767377201112141 0.473684210526316 2.1 2 1 abnormal neurotransmitter level 0.274158960043022 0.675744316057538 0.767377201112141 0.473684210526316 2.1 2 1 abnormal neural crest cell migration 0.274158960043022 0.675744316057538 0.767377201112141 0.473684210526316 2.1 2 1 oliguria 0.274158960043022 0.675744316057538 0.767377201112141 0.473684210526316 2.1 2 1 increased liver cholesterol level 0.274158960043022 0.675744316057538 0.767377201112141 0.473684210526316 2.1 2 1 decreased liver glycogen level 0.274158960043022 0.675744316057538 0.767377201112141 0.473684210526316 2.1 2 1 reduced long term potentiation 0.0297624941784188 0.158023915194913 0.766615914206276 0.473214285714286 2.1 2 1 cochlear outer hair cell degeneration 0.0730784772211676 0.286878659400099 0.76500875296056 0.472222222222222 2.1 2 1 heart right ventricle hypertrophy 0.17139556949223 0.469835376976869 0.76500875296056 0.472222222222222 2.1 2 1 abnormal adipose tissue morphology 0.302161448984099 0.675744316057538 0.76236166384997 0.470588235294118 2.1 2 1 absence seizures 0.302161448984099 0.675744316057538 0.76236166384997 0.470588235294118 2.1 2 1 abnormal involuntary movement 0.302161448984099 0.675744316057538 0.76236166384997 0.470588235294118 2.1 2 1 decreased growth hormone level 0.302161448984099 0.675744316057538 0.76236166384997 0.470588235294118 2.1 2 1 abnormal tail morphology 0.0900911564649692 0.326678938347829 0.760917797062375 0.46969696969697 2.1 2 1 abnormal respiratory system physiology 0.132323222514384 0.436941280948118 0.760416863687087 0.469387755102041 2.1 2 1 abnormal depression-related behavior 0.201492254984905 0.53922752477133 0.759383688600556 0.46875 2.1 2 1 abnormal serotonin level 0.201492254984905 0.53922752477133 0.759383688600556 0.46875 2.1 2 1 pulmonary hypoplasia 0.142574646040556 0.436941280948118 0.758306548616725 0.468085106382979 2.1 2 1 decreased insulin secretion 0.0613375230957367 0.256647752229849 0.756008649984554 0.466666666666667 2.1 2 1 increased circulating corticosterone level 0.153713210366721 0.438948026086241 0.756008649984554 0.466666666666667 2.1 2 1 lethality at weaning, complete penetrance 0.153713210366721 0.438948026086241 0.756008649984554 0.466666666666667 2.1 2 1 abnormal heart tube morphology 0.218876807248919 0.57462380794901 0.756008649984554 0.466666666666667 2.1 2 1 enhanced paired-pulse facilitation 0.218876807248919 0.57462380794901 0.756008649984554 0.466666666666667 2.1 2 1 abnormal microglial cell physiology 0.218876807248919 0.57462380794901 0.756008649984554 0.466666666666667 2.1 2 1 abnormal seizure response to electrical stimulation 0.334419658636954 0.675744316057538 0.756008649984554 0.466666666666667 2.1 2 1 abnormal apical ectodermal ridge morphology 0.334419658636954 0.675744316057538 0.756008649984554 0.466666666666667 2.1 2 1 abnormal respiratory system morphology 0.334419658636954 0.675744316057538 0.756008649984554 0.466666666666667 2.1 2 1 abnormal cricoid cartilage morphology 0.334419658636954 0.675744316057538 0.756008649984554 0.466666666666667 2.1 2 1 abnormal bronchus morphology 0.334419658636954 0.675744316057538 0.756008649984554 0.466666666666667 2.1 2 1 joint inflammation 0.334419658636954 0.675744316057538 0.756008649984554 0.466666666666667 2.1 2 1 decreased trabecular bone mass 0.334419658636954 0.675744316057538 0.756008649984554 0.466666666666667 2.1 2 1 abnormal branching involved in lung morphogenesis 0.334419658636954 0.675744316057538 0.756008649984554 0.466666666666667 2.1 2 1 increased liver weight 0.0655521726827482 0.270642827945195 0.754781363215098 0.465909090909091 2.1 2 1 abnormal organ of Corti morphology 0.165829955167981 0.455551643821484 0.753496993340087 0.465116279069767 2.1 2 1 abnormal intestinal mucosa morphology 0.165829955167981 0.455551643821484 0.753496993340087 0.465116279069767 2.1 2 1 increased body weight 0.00690675181264967 0.0527010586931474 0.752151462994836 0.464285714285714 2.1 2 1 abnormal neuron differentiation 0.0451863765052595 0.205674495071972 0.752151462994836 0.464285714285714 2.1 2 1 increased circulating luteinizing hormone level 0.238105270401748 0.611235149767128 0.752151462994836 0.464285714285714 2.1 2 1 absent corpus callosum 0.238105270401748 0.611235149767128 0.752151462994836 0.464285714285714 2.1 2 1 enhanced coordination 0.238105270401748 0.611235149767128 0.752151462994836 0.464285714285714 2.1 2 1 hypoxia 0.238105270401748 0.611235149767128 0.752151462994836 0.464285714285714 2.1 2 1 abnormal epidermal layer morphology 0.100961220432742 0.362658535489454 0.751312944084028 0.463768115942029 2.1 2 1 abnormal response/metabolism to endogenous compounds 0.0800812782410785 0.293996796249452 0.750740297022989 0.463414634146341 2.1 2 1 decreased kidney weight 0.148501274768704 0.438948026086241 0.747700862622086 0.461538461538462 2.1 2 1 abnormal kidney cortex morphology 0.25944582114685 0.647638213851268 0.747700862622086 0.461538461538462 2.1 2 1 abnormal ocular fundus morphology 0.25944582114685 0.647638213851268 0.747700862622086 0.461538461538462 2.1 2 1 absent teeth 0.372069804395766 0.675744316057538 0.747700862622086 0.461538461538462 2.1 2 1 small trigeminal ganglion 0.372069804395766 0.675744316057538 0.747700862622086 0.461538461538462 2.1 2 1 abnormal pulmonary alveolus epithelial cell morphology 0.372069804395766 0.675744316057538 0.747700862622086 0.461538461538462 2.1 2 1 abnormal otolith morphology 0.372069804395766 0.675744316057538 0.747700862622086 0.461538461538462 2.1 2 1 abnormal bile duct development 0.372069804395766 0.675744316057538 0.747700862622086 0.461538461538462 2.1 2 1 absent lateral semicircular canal 0.372069804395766 0.675744316057538 0.747700862622086 0.461538461538462 2.1 2 1 small otic vesicle 0.372069804395766 0.675744316057538 0.747700862622086 0.461538461538462 2.1 2 1 decreased endocochlear potential 0.372069804395766 0.675744316057538 0.747700862622086 0.461538461538462 2.1 2 1 decreased luteinizing hormone level 0.372069804395766 0.675744316057538 0.747700862622086 0.461538461538462 2.1 2 1 abnormal vertebral arch development 0.372069804395766 0.675744316057538 0.747700862622086 0.461538461538462 2.1 2 1 increased thermal nociceptive threshold 0.0729087046193996 0.286878659400099 0.747700862622086 0.461538461538462 2.1 2 1 abnormal heart ventricle morphology 0.0915829320655802 0.331846385306818 0.747700862622086 0.461538461538462 2.1 2 1 abnormal humerus morphology 0.20914928596922 0.552878691656148 0.744332840718383 0.459459459459459 2.1 2 1 cardiac hypertrophy 0.0708195199639486 0.286878659400099 0.743886062302586 0.459183673469388 2.1 2 1 circling 0.0887928285016951 0.322275396448989 0.743302622253721 0.458823529411765 2.1 2 1 abnormal foregut morphology 0.283223906776361 0.675744316057538 0.742508495520544 0.458333333333333 2.1 2 1 curly vibrissae 0.283223906776361 0.675744316057538 0.742508495520544 0.458333333333333 2.1 2 1 increased stereotypic behavior 0.283223906776361 0.675744316057538 0.742508495520544 0.458333333333333 2.1 2 1 decreased fatty acid level 0.283223906776361 0.675744316057538 0.742508495520544 0.458333333333333 2.1 2 1 increased circulating total protein level 0.283223906776361 0.675744316057538 0.742508495520544 0.458333333333333 2.1 2 1 abnormal heart left ventricle morphology 0.112140896182236 0.394834365539012 0.742508495520544 0.458333333333333 2.1 2 1 delayed wound healing 0.185120846775709 0.501075197339038 0.739573679332716 0.456521739130435 2.1 2 1 obese 0.115649501611642 0.405466011640536 0.736372061673267 0.454545454545455 2.1 2 1 polyuria 0.115649501611642 0.405466011640536 0.736372061673267 0.454545454545455 2.1 2 1 impaired swimming 0.137530163025966 0.436941280948118 0.736372061673267 0.454545454545455 2.1 2 1 increased circulating calcium level 0.164763248038725 0.453121702041268 0.736372061673267 0.454545454545455 2.1 2 1 abnormal circadian rhythm 0.199439081597988 0.534307717259016 0.736372061673266 0.454545454545455 2.1 2 1 abnormal enterocyte morphology 0.309839904844554 0.675744316057538 0.736372061673266 0.454545454545455 2.1 2 1 decreased airway responsiveness 0.309839904844554 0.675744316057538 0.736372061673266 0.454545454545455 2.1 2 1 increased coping response 0.309839904844554 0.675744316057538 0.736372061673266 0.454545454545455 2.1 2 1 abnormal retinal layer morphology 0.309839904844554 0.675744316057538 0.736372061673266 0.454545454545455 2.1 2 1 abnormal limb posture 0.309839904844554 0.675744316057538 0.736372061673266 0.454545454545455 2.1 2 1 decreased susceptibility to viral infection induced morbidity/mortality 0.309839904844554 0.675744316057538 0.736372061673266 0.454545454545455 2.1 2 1 failure of palatal shelf elevation 0.309839904844554 0.675744316057538 0.736372061673266 0.454545454545455 2.1 2 1 abnormal ear position 0.416782066069557 0.715383762032216 0.736372061673266 0.454545454545455 2.1 2 1 abnormal awl hair morphology 0.416782066069557 0.715383762032216 0.736372061673266 0.454545454545455 2.1 2 1 social withdrawal 0.416782066069557 0.715383762032216 0.736372061673266 0.454545454545455 2.1 2 1 abnormal primary sex determination 0.416782066069557 0.715383762032216 0.736372061673266 0.454545454545455 2.1 2 1 abnormal bronchiole morphology 0.416782066069557 0.715383762032216 0.736372061673266 0.454545454545455 2.1 2 1 decreased post-tetanic potentiation 0.416782066069557 0.715383762032216 0.736372061673266 0.454545454545455 2.1 2 1 patent ductus arteriosus 0.416782066069557 0.715383762032216 0.736372061673266 0.454545454545455 2.1 2 1 abnormal nerve fiber response 0.416782066069557 0.715383762032216 0.736372061673266 0.454545454545455 2.1 2 1 pulmonary hypertension 0.416782066069557 0.715383762032216 0.736372061673266 0.454545454545455 2.1 2 1 dilated renal glomerular capsule 0.416782066069557 0.715383762032216 0.736372061673266 0.454545454545455 2.1 2 1 abnormal ureter development 0.416782066069557 0.715383762032216 0.736372061673266 0.454545454545455 2.1 2 1 enlarged placenta 0.416782066069557 0.715383762032216 0.736372061673266 0.454545454545455 2.1 2 1 increased motor neuron number 0.416782066069557 0.715383762032216 0.736372061673266 0.454545454545455 2.1 2 1 abnormal platelet aggregation 0.416782066069557 0.715383762032216 0.736372061673266 0.454545454545455 2.1 2 1 decreased palatine bone horizontal plate size 0.416782066069557 0.715383762032216 0.736372061673266 0.454545454545455 2.1 2 1 abnormal limb morphology 0.123581594224117 0.429642509619136 0.734408402842138 0.453333333333333 2.1 2 1 abnormal optic nerve morphology 0.214987625776514 0.565308371161816 0.732865528046251 0.452380952380952 2.1 2 1 abnormal cranial ganglia morphology 0.265952913205074 0.662220091689312 0.7316212741786 0.451612903225806 2.1 2 1 abnormal eyelid morphology 0.265952913205074 0.662220091689312 0.7316212741786 0.451612903225806 2.1 2 1 abnormal retinal photoreceptor layer morphology 0.265952913205074 0.662220091689312 0.7316212741786 0.451612903225806 2.1 2 1 decreased neuronal precursor cell number 0.265952913205074 0.662220091689312 0.7316212741786 0.451612903225806 2.1 2 1 abnormal response to novel object 0.190029727687904 0.511855925959569 0.730596594522888 0.450980392156863 2.1 2 1 increased susceptibility to weight loss 0.231889991241943 0.598988944147802 0.729008341056534 0.45 2.1 2 1 increased urine glucose level 0.339794200566454 0.675744316057538 0.729008341056534 0.45 2.1 2 1 abnormal fibula morphology 0.339794200566454 0.675744316057538 0.729008341056534 0.45 2.1 2 1 absent placental labyrinth 0.339794200566454 0.675744316057538 0.729008341056534 0.45 2.1 2 1 enhanced behavioral response to xenobiotic 0.339794200566454 0.675744316057538 0.729008341056534 0.45 2.1 2 1 nuclear cataracts 0.339794200566454 0.675744316057538 0.729008341056534 0.45 2.1 2 1 decreased muscle cell glucose uptake 0.339794200566454 0.675744316057538 0.729008341056534 0.45 2.1 2 1 cochlear ganglion degeneration 0.181031745908437 0.490273781107498 0.726215205650187 0.448275862068966 2.1 2 1 glomerulosclerosis 0.181031745908437 0.490273781107498 0.726215205650187 0.448275862068966 2.1 2 1 abnormal circulating glucose level 0.288778000651122 0.675744316057538 0.726215205650187 0.448275862068966 2.1 2 1 focal hair loss 0.288778000651122 0.675744316057538 0.726215205650187 0.448275862068966 2.1 2 1 stomach inflammation 0.288778000651122 0.675744316057538 0.726215205650187 0.448275862068966 2.1 2 1 abnormal reproductive system physiology 0.250284845261091 0.640188743020015 0.724745134383689 0.447368421052632 2.1 2 1 short mandible 0.194008356043566 0.520599553029526 0.723222560571958 0.446428571428571 2.1 2 1 increased anxiety-related response 0.0706440673614299 0.286878659400099 0.722598195771464 0.446043165467626 2.1 2 1 abnormal digit morphology 0.164380454813004 0.452319005915208 0.720008238080527 0.444444444444444 2.1 2 1 abnormal chondrocyte morphology 0.207960653082892 0.550321409089036 0.720008238080527 0.444444444444444 2.1 2 1 renal hypoplasia 0.270328290182937 0.672441621830056 0.720008238080527 0.444444444444444 2.1 2 1 head tilt 0.270328290182937 0.672441621830056 0.720008238080527 0.444444444444444 2.1 2 1 abnormal retinal rod cell morphology 0.373723716934817 0.675744316057538 0.720008238080527 0.444444444444444 2.1 2 1 abnormal phrenic nerve morphology 0.373723716934817 0.675744316057538 0.720008238080527 0.444444444444444 2.1 2 1 thin epidermis 0.313977823831061 0.675744316057538 0.720008238080527 0.444444444444444 2.1 2 1 abnormal type II pneumocyte morphology 0.313977823831061 0.675744316057538 0.720008238080527 0.444444444444444 2.1 2 1 increased circulating renin level 0.373723716934817 0.675744316057538 0.720008238080527 0.444444444444444 2.1 2 1 abnormal body wall morphology 0.373723716934817 0.675744316057538 0.720008238080527 0.444444444444444 2.1 2 1 abnormal anterior eye segment morphology 0.373723716934817 0.675744316057538 0.720008238080527 0.444444444444444 2.1 2 1 decreased pulmonary respiratory rate 0.373723716934817 0.675744316057538 0.720008238080527 0.444444444444444 2.1 2 1 abnormal sperm axoneme morphology 0.373723716934817 0.675744316057538 0.720008238080527 0.444444444444444 2.1 2 1 atrioventricular block 0.373723716934817 0.675744316057538 0.720008238080527 0.444444444444444 2.1 2 1 impaired fertilization 0.175443923954268 0.478282655924205 0.717436780087382 0.442857142857143 2.1 2 1 decreased susceptibility to injury 0.187258802838747 0.506586484025432 0.714714059859347 0.441176470588235 2.1 2 1 thin skin 0.292196530523442 0.675744316057538 0.714714059859347 0.441176470588235 2.1 2 1 impaired synaptic plasticity 0.292196530523442 0.675744316057538 0.714714059859347 0.441176470588235 2.1 2 1 increased susceptibility to weight gain 0.292196530523442 0.675744316057538 0.714714059859347 0.441176470588235 2.1 2 1 abnormal axon extension 0.239108413255279 0.613493736949464 0.712808155699722 0.44 2.1 2 1 decreased placenta weight 0.341880482032564 0.675744316057538 0.712808155699722 0.44 2.1 2 1 abnormal phalanx morphology 0.25647811615731 0.645738172005374 0.708758109360519 0.4375 2.1 2 1 increased dopamine level 0.316088980709651 0.675744316057538 0.708758109360519 0.4375 2.1 2 1 abnormal heart atrium morphology 0.316088980709651 0.675744316057538 0.708758109360519 0.4375 2.1 2 1 abnormal auditory brainstem response waveform shape 0.316088980709651 0.675744316057538 0.708758109360519 0.4375 2.1 2 1 vasculature congestion 0.412456672073732 0.715383762032216 0.708758109360519 0.4375 2.1 2 1 abnormal epicardium morphology 0.412456672073732 0.715383762032216 0.708758109360519 0.4375 2.1 2 1 decreased cochlear coiling 0.412456672073732 0.715383762032216 0.708758109360519 0.4375 2.1 2 1 abnormal molar crown morphology 0.412456672073732 0.715383762032216 0.708758109360519 0.4375 2.1 2 1 bowed tibia 0.412456672073732 0.715383762032216 0.708758109360519 0.4375 2.1 2 1 bowed radius 0.412456672073732 0.715383762032216 0.708758109360519 0.4375 2.1 2 1 sepsis 0.412456672073732 0.715383762032216 0.708758109360519 0.4375 2.1 2 1 decreased circulating prolactin level 0.412456672073732 0.715383762032216 0.708758109360519 0.4375 2.1 2 1 kidney degeneration 0.412456672073732 0.715383762032216 0.708758109360519 0.4375 2.1 2 1 abnormal learning/memory/conditioning 0.241403805375151 0.619063882340916 0.706917179206336 0.436363636363636 2.1 2 1 abnormal iris morphology 0.29422339122607 0.675744316057538 0.706161925809748 0.435897435897436 2.1 2 1 abnormal innervation pattern to muscle 0.372877158878032 0.675744316057538 0.704355885078777 0.434782608695652 2.1 2 1 hypotension 0.372877158878032 0.675744316057538 0.704355885078777 0.434782608695652 2.1 2 1 increased susceptibility to fungal infection 0.372877158878032 0.675744316057538 0.704355885078777 0.434782608695652 2.1 2 1 abnormal palatal shelf fusion at midline 0.372877158878032 0.675744316057538 0.704355885078777 0.434782608695652 2.1 2 1 abnormal basicranium morphology 0.372877158878032 0.675744316057538 0.704355885078777 0.434782608695652 2.1 2 1 abnormal pancreatic islet morphology 0.258271286526983 0.646424632826137 0.703026911710704 0.433962264150943 2.1 2 1 abnormal kidney development 0.243082106191147 0.623046614271486 0.702008032128514 0.433333333333333 2.1 2 1 impaired skeletal muscle contractility 0.31694086482196 0.675744316057538 0.700548555970243 0.432432432432432 2.1 2 1 decreased circulating chloride level 0.31694086482196 0.675744316057538 0.700548555970243 0.432432432432432 2.1 2 1 small kidney 0.194411565143398 0.521119362385995 0.699553458589603 0.431818181818182 2.1 2 1 short femur 0.194411565143398 0.521119362385995 0.699553458589603 0.431818181818182 2.1 2 1 increased kidney weight 0.27634051954777 0.675744316057538 0.698831525195806 0.431372549019608 2.1 2 1 abnormal blood homeostasis 0.167520066801453 0.459940580760059 0.69632375656472 0.429824561403509 2.1 2 1 organ of Corti degeneration 0.295695108835078 0.675744316057538 0.69429365814908 0.428571428571429 2.1 2 1 absent kidney 0.295695108835078 0.675744316057538 0.69429365814908 0.428571428571429 2.1 2 1 decreased vocalization 0.407438274892678 0.715383762032216 0.69429365814908 0.428571428571429 2.1 2 1 abnormal circulating cholesterol level 0.370882238903046 0.675744316057538 0.69429365814908 0.428571428571429 2.1 2 1 abnormal respiration 0.370882238903046 0.675744316057538 0.69429365814908 0.428571428571429 2.1 2 1 increased triglyceride level 0.370882238903046 0.675744316057538 0.69429365814908 0.428571428571429 2.1 2 1 abnormal pinna reflex 0.457097316895076 0.774807206662012 0.69429365814908 0.428571428571429 2.1 2 1 abnormal adrenal gland secretion 0.457097316895076 0.774807206662012 0.69429365814908 0.428571428571429 2.1 2 1 abnormal fluid regulation 0.457097316895076 0.774807206662012 0.69429365814908 0.428571428571429 2.1 2 1 absent otoliths 0.457097316895076 0.774807206662012 0.69429365814908 0.428571428571429 2.1 2 1 abnormal uterus development 0.457097316895076 0.774807206662012 0.69429365814908 0.428571428571429 2.1 2 1 abnormal hair cuticle 0.457097316895076 0.774807206662012 0.69429365814908 0.428571428571429 2.1 2 1 abnormal decidualization 0.457097316895076 0.774807206662012 0.69429365814908 0.428571428571429 2.1 2 1 decreased tongue size 0.457097316895076 0.774807206662012 0.69429365814908 0.428571428571429 2.1 2 1 sternebra fusion 0.457097316895076 0.774807206662012 0.69429365814908 0.428571428571429 2.1 2 1 increased lung compliance 0.457097316895076 0.774807206662012 0.69429365814908 0.428571428571429 2.1 2 1 abnormal respiratory motile cilium physiology 0.457097316895076 0.774807206662012 0.69429365814908 0.428571428571429 2.1 2 1 abnormal urine homeostasis 0.207669635520129 0.549843766212157 0.691882916280507 0.427083333333333 2.1 2 1 abnormal excitatory postsynaptic potential 0.231848712590529 0.598988944147802 0.691471326205384 0.426829268292683 2.1 2 1 abnormal long bone epiphyseal plate proliferative zone 0.295598530695179 0.675744316057538 0.690007894827172 0.425925925925926 2.1 2 1 abnormal innervation 0.316422963953208 0.675744316057538 0.689369589651569 0.425531914893617 2.1 2 1 abnormal skin pigmentation 0.340295904257816 0.675744316057538 0.688507877664504 0.425 2.1 2 1 abnormal aorta morphology 0.368304461599954 0.675744316057538 0.687280590895049 0.424242424242424 2.1 2 1 absent vibrissae 0.368304461599954 0.675744316057538 0.687280590895049 0.424242424242424 2.1 2 1 decreased systemic arterial blood pressure 0.368304461599954 0.675744316057538 0.687280590895049 0.424242424242424 2.1 2 1 diarrhea 0.368304461599954 0.675744316057538 0.687280590895049 0.424242424242424 2.1 2 1 abnormal autopod morphology 0.338615904804871 0.675744316057538 0.684007826176501 0.422222222222222 2.1 2 1 abnormal lipid level 0.260091247064928 0.648923748318966 0.683140346371585 0.421686746987952 2.1 2 1 abnormal eye electrophysiology 0.208479036859216 0.551399898125783 0.682817729915211 0.421487603305785 2.1 2 1 decreased threshold for auditory brainstem response 0.365417969957137 0.675744316057538 0.682113067655236 0.421052631578947 2.1 2 1 stereotypic behavior 0.446134449219758 0.759329074535852 0.682113067655236 0.421052631578947 2.1 2 1 abnormal photoreceptor inner segment morphology 0.446134449219758 0.759329074535852 0.682113067655236 0.421052631578947 2.1 2 1 increased circulating VLDL cholesterol level 0.446134449219758 0.759329074535852 0.682113067655236 0.421052631578947 2.1 2 1 eyelids fail to open 0.446134449219758 0.759329074535852 0.682113067655236 0.421052631578947 2.1 2 1 abnormal coat appearance 0.293426690715564 0.675744316057538 0.680877355576151 0.420289855072464 2.1 2 1 decreased susceptibility to bacterial infection induced morbidity/mortality 0.397322200868979 0.702194653400771 0.679362611737272 0.419354838709677 2.1 2 1 abnormal femur morphology 0.311220955328074 0.675744316057538 0.677022671627958 0.417910447761194 2.1 2 1 hydronephrosis 0.28967615475923 0.675744316057538 0.675007723200494 0.416666666666667 2.1 2 1 increased susceptibility to pharmacologically induced seizures 0.272099479322132 0.675744316057538 0.675007723200494 0.416666666666667 2.1 2 1 abnormal hair shaft morphology 0.359240712378849 0.675744316057538 0.675007723200494 0.416666666666667 2.1 2 1 abnormal epidermis stratum granulosum morphology 0.392465994456284 0.69385867889837 0.675007723200494 0.416666666666667 2.1 2 1 short radius 0.392465994456284 0.69385867889837 0.675007723200494 0.416666666666667 2.1 2 1 abnormal adrenal gland morphology 0.436915196093511 0.744656766209393 0.675007723200494 0.416666666666667 2.1 2 1 abnormal sensory capabilities/reflexes/nociception 0.436915196093511 0.744656766209393 0.675007723200494 0.416666666666667 2.1 2 1 decreased ovulation rate 0.436915196093511 0.744656766209393 0.675007723200494 0.416666666666667 2.1 2 1 abnormal retinal ganglion layer morphology 0.436915196093511 0.744656766209393 0.675007723200494 0.416666666666667 2.1 2 1 abnormal lung saccule morphology 0.436915196093511 0.744656766209393 0.675007723200494 0.416666666666667 2.1 2 1 abnormal supraoccipital bone morphology 0.509161691373063 0.81580657474428 0.675007723200494 0.416666666666667 2.1 2 1 abnormal rectum morphology 0.509161691373063 0.81580657474428 0.675007723200494 0.416666666666667 2.1 2 1 abnormal superior cervical ganglion morphology 0.509161691373063 0.81580657474428 0.675007723200494 0.416666666666667 2.1 2 1 abnormal aorta elastic fiber morphology 0.509161691373063 0.81580657474428 0.675007723200494 0.416666666666667 2.1 2 1 vestibular saccular macula degeneration 0.509161691373063 0.81580657474428 0.675007723200494 0.416666666666667 2.1 2 1 stria vascularis degeneration 0.509161691373063 0.81580657474428 0.675007723200494 0.416666666666667 2.1 2 1 increased placenta weight 0.509161691373063 0.81580657474428 0.675007723200494 0.416666666666667 2.1 2 1 hematuria 0.509161691373063 0.81580657474428 0.675007723200494 0.416666666666667 2.1 2 1 abnormal palatine bone morphology 0.509161691373063 0.81580657474428 0.675007723200494 0.416666666666667 2.1 2 1 hemoperitoneum 0.509161691373063 0.81580657474428 0.675007723200494 0.416666666666667 2.1 2 1 hydrometra 0.509161691373063 0.81580657474428 0.675007723200494 0.416666666666667 2.1 2 1 abnormal colon goblet cell morphology 0.509161691373063 0.81580657474428 0.675007723200494 0.416666666666667 2.1 2 1 short humerus 0.387779346076677 0.686060542934377 0.671715002599516 0.414634146341463 2.1 2 1 abnormal CNS synaptic transmission 0.285165346267274 0.675744316057538 0.670916767302309 0.414141414141414 2.1 2 1 abnormal middle ear morphology 0.428838171786757 0.732899314544526 0.670352497523249 0.413793103448276 2.1 2 1 abnormal spinal nerve morphology 0.428838171786757 0.732899314544526 0.670352497523249 0.413793103448276 2.1 2 1 abnormal forelimb morphology 0.383261050484118 0.678307978000173 0.669138090824838 0.41304347826087 2.1 2 1 abnormal social investigation 0.322825968873745 0.675744316057538 0.668257645968489 0.4125 2.1 2 1 abnormal bone remodeling 0.421580013353513 0.721238159021226 0.667066455868724 0.411764705882353 2.1 2 1 decreased osteoblast cell number 0.421580013353513 0.721238159021226 0.667066455868724 0.411764705882353 2.1 2 1 hydroureter 0.489663328236475 0.794644773395871 0.667066455868724 0.411764705882353 2.1 2 1 abnormal vagus nerve morphology 0.489663328236475 0.794644773395871 0.667066455868724 0.411764705882353 2.1 2 1 abnormal circulating chemokine level 0.489663328236475 0.794644773395871 0.667066455868724 0.411764705882353 2.1 2 1 abnormal cued conditioning behavior 0.378903494860292 0.675744316057538 0.667066455868724 0.411764705882353 2.1 2 1 cochlear inner hair cell degeneration 0.378903494860292 0.675744316057538 0.667066455868724 0.411764705882353 2.1 2 1 impaired righting response 0.315605054642254 0.675744316057538 0.665060240963855 0.410526315789474 2.1 2 1 small lens 0.414944633422228 0.715383762032216 0.66462298899741 0.41025641025641 2.1 2 1 abnormal cochlear sensory epithelium morphology 0.475006377233686 0.794644773395871 0.66273485550594 0.409090909090909 2.1 2 1 abnormal temporal bone morphology 0.475006377233686 0.794644773395871 0.66273485550594 0.409090909090909 2.1 2 1 atelectasis 0.362882414697484 0.675744316057538 0.661697711757104 0.408450704225352 2.1 2 1 abnormal mandible morphology 0.397665665180796 0.702302692323203 0.660007551573817 0.407407407407407 2.1 2 1 polyphagia 0.397665665180796 0.702302692323203 0.660007551573817 0.407407407407407 2.1 2 1 abnormal heart valve morphology 0.46307645239217 0.784407678124293 0.660007551573817 0.407407407407407 2.1 2 1 decreased susceptibility to pharmacologically induced seizures 0.46307645239217 0.784407678124293 0.660007551573817 0.407407407407407 2.1 2 1 abnormal long term potentiation 0.452902825188519 0.770585347234228 0.658132530120482 0.40625 2.1 2 1 increased food intake 0.370218763584948 0.675744316057538 0.655721788251909 0.404761904761905 2.1 2 1 abnormal cartilage morphology 0.435933046743725 0.744257689619091 0.655721788251909 0.404761904761905 2.1 2 1 abnormal hair growth 0.421866598691983 0.72148034668017 0.654238254794325 0.403846153846154 2.1 2 1 head bobbing 0.464710452865169 0.786639844506368 0.648007414272475 0.4 2.1 2 1 waved hair 0.517027948321961 0.827344497556049 0.648007414272475 0.4 2.1 2 1 abnormal hair texture 0.517027948321961 0.827344497556049 0.648007414272475 0.4 2.1 2 1 abnormal lens epithelium morphology 0.517027948321961 0.827344497556049 0.648007414272475 0.4 2.1 2 1 dehydration 0.420000565100555 0.719030561381714 0.648007414272474 0.4 2.1 2 1 abnormal hair cycle 0.486575716691742 0.794644773395871 0.648007414272474 0.4 2.1 2 1 abnormal lactation 0.486575716691742 0.794644773395871 0.648007414272474 0.4 2.1 2 1 abnormal estrous cycle 0.486575716691742 0.794644773395871 0.648007414272474 0.4 2.1 2 1 diaphragmatic hernia 0.500271672134143 0.805453582157722 0.648007414272474 0.4 2.1 2 1 abnormal energy expenditure 0.500271672134143 0.805453582157722 0.648007414272474 0.4 2.1 2 1 abnormal stomach mucosa morphology 0.500271672134143 0.805453582157722 0.648007414272474 0.4 2.1 2 1 absent incisors 0.538882422400492 0.850144192317716 0.648007414272474 0.4 2.1 2 1 interdigital webbing 0.538882422400492 0.850144192317716 0.648007414272474 0.4 2.1 2 1 decreased salivation 0.538882422400492 0.850144192317716 0.648007414272474 0.4 2.1 2 1 abnormal pup retrieval 0.538882422400492 0.850144192317716 0.648007414272474 0.4 2.1 2 1 no suckling reflex 0.538882422400492 0.850144192317716 0.648007414272474 0.4 2.1 2 1 increased alcohol consumption 0.538882422400492 0.850144192317716 0.648007414272474 0.4 2.1 2 1 dilated ureter 0.538882422400492 0.850144192317716 0.648007414272474 0.4 2.1 2 1 abnormal glial cell morphology 0.538882422400492 0.850144192317716 0.648007414272474 0.4 2.1 2 1 abnormal ear development 0.538882422400492 0.850144192317716 0.648007414272474 0.4 2.1 2 1 abnormal energy homeostasis 0.538882422400492 0.850144192317716 0.648007414272474 0.4 2.1 2 1 absent chorion 0.538882422400492 0.850144192317716 0.648007414272474 0.4 2.1 2 1 lactation failure 0.538882422400492 0.850144192317716 0.648007414272474 0.4 2.1 2 1 ostium primum atrial septal defect 0.538882422400492 0.850144192317716 0.648007414272474 0.4 2.1 2 1 abnormal excitatory postsynaptic currents 0.429001023163122 0.732925855163644 0.643853520591241 0.397435897435897 2.1 2 1 decreased cardiac muscle contractility 0.432317234480757 0.738337879005068 0.638661153489698 0.394230769230769 2.1 2 1 dilated heart atrium 0.507891761521087 0.81580657474428 0.638189120116831 0.393939393939394 2.1 2 1 head tossing 0.507891761521087 0.81580657474428 0.638189120116831 0.393939393939394 2.1 2 1 abnormal hormone level 0.522731531708662 0.836202369855497 0.636435853303323 0.392857142857143 2.1 2 1 decreased food intake 0.464307016788977 0.786224441295153 0.635703476026795 0.392405063291139 2.1 2 1 abnormal gluconeogenesis 0.491472277045541 0.794644773395871 0.635301386541642 0.392156862745098 2.1 2 1 fragile skeleton 0.540660874748035 0.850929405843554 0.633920296570899 0.391304347826087 2.1 2 1 abnormal blood vessel physiology 0.540660874748035 0.850929405843554 0.633920296570899 0.391304347826087 2.1 2 1 abnormal carpal bone morphology 0.540660874748035 0.850929405843554 0.633920296570899 0.391304347826087 2.1 2 1 short ulna 0.513946361209804 0.823207709922336 0.63220235538778 0.390243902439024 2.1 2 1 abnormal colon morphology 0.497782542115653 0.802224861362284 0.631532649502835 0.389830508474576 2.1 2 1 abnormal cochlea morphology 0.507910066545732 0.81580657474428 0.630007208320461 0.388888888888889 2.1 2 1 abnormal systemic arterial blood pressure 0.527385002482065 0.843375245049269 0.630007208320461 0.388888888888889 2.1 2 1 absent spleen 0.563443080882984 0.881771626800117 0.630007208320461 0.388888888888889 2.1 2 1 absent ureter 0.563443080882984 0.881771626800117 0.630007208320461 0.388888888888889 2.1 2 1 decreased fluid intake 0.563443080882984 0.881771626800117 0.630007208320461 0.388888888888889 2.1 2 1 abnormal photoreceptor outer segment morphology 0.53139940812899 0.849248973800747 0.625916252422276 0.386363636363636 2.1 2 1 abnormal amino acid level 0.53139940812899 0.849248973800747 0.625916252422276 0.386363636363636 2.1 2 1 increased susceptibility to injury 0.534975826016513 0.850144192317716 0.623084052185072 0.384615384615385 2.1 2 1 absent myocardial trabeculae 0.594844120733874 0.881771626800117 0.623084052185072 0.384615384615385 2.1 2 1 short hair 0.594844120733874 0.881771626800117 0.623084052185072 0.384615384615385 2.1 2 1 pup cannibalization 0.594844120733874 0.881771626800117 0.623084052185072 0.384615384615385 2.1 2 1 abnormal lung interstitium morphology 0.594844120733874 0.881771626800117 0.623084052185072 0.384615384615385 2.1 2 1 dystrophic cardiac calcinosis 0.594844120733874 0.881771626800117 0.623084052185072 0.384615384615385 2.1 2 1 abnormal soleus morphology 0.594844120733874 0.881771626800117 0.623084052185072 0.384615384615385 2.1 2 1 decreased alcohol consumption 0.594844120733874 0.881771626800117 0.623084052185072 0.384615384615385 2.1 2 1 abnormal insulin secretion 0.594844120733874 0.881771626800117 0.623084052185072 0.384615384615385 2.1 2 1 muscle fatigue 0.594844120733874 0.881771626800117 0.623084052185072 0.384615384615385 2.1 2 1 vestibular hair cell degeneration 0.594844120733874 0.881771626800117 0.623084052185072 0.384615384615385 2.1 2 1 small interparietal bone 0.594844120733874 0.881771626800117 0.623084052185072 0.384615384615385 2.1 2 1 decreased follicle stimulating hormone level 0.594844120733874 0.881771626800117 0.623084052185072 0.384615384615385 2.1 2 1 decreased cardiac stroke volume 0.594844120733874 0.881771626800117 0.623084052185072 0.384615384615385 2.1 2 1 abnormal lens fiber morphology 0.545333158267512 0.858011531429751 0.623084052185072 0.384615384615385 2.1 2 1 overexpanded pulmonary alveoli 0.561322843720061 0.881771626800117 0.619418851878101 0.382352941176471 2.1 2 1 decreased pancreatic beta cell number 0.561322843720061 0.881771626800117 0.619418851878101 0.382352941176471 2.1 2 1 abnormal nervous system electrophysiology 0.546668913039224 0.859841240079083 0.617149918354738 0.380952380952381 2.1 2 1 small ears 0.584467747355367 0.881771626800117 0.617149918354738 0.380952380952381 2.1 2 1 abnormal anxiety-related response 0.584467747355367 0.881771626800117 0.617149918354738 0.380952380952381 2.1 2 1 abnormal hindlimb morphology 0.562986630486279 0.881771626800117 0.615607043558851 0.38 2.1 2 1 aphagia 0.580110807216494 0.881771626800117 0.614489789396312 0.379310344827586 2.1 2 1 abnormal cartilage development 0.5774238328548 0.881771626800117 0.612007002368448 0.377777777777778 2.1 2 1 abnormal malleus morphology 0.602908281940748 0.881771626800117 0.607506950880445 0.375 2.1 2 1 abnormal pituitary gland morphology 0.614737872596548 0.881771626800117 0.607506950880445 0.375 2.1 2 1 abnormal intestinal absorption 0.614737872596548 0.881771626800117 0.607506950880445 0.375 2.1 2 1 apnea 0.602908281940748 0.881771626800117 0.607506950880445 0.375 2.1 2 1 abnormal cardiovascular system morphology 0.591882826759121 0.881771626800117 0.607506950880445 0.375 2.1 2 1 abnormal diaphragm morphology 0.596972478109312 0.881771626800117 0.607506950880445 0.375 2.1 2 1 abnormal cardiac muscle contractility 0.602908281940748 0.881771626800117 0.607506950880445 0.375 2.1 2 1 impaired muscle relaxation 0.614737872596548 0.881771626800117 0.607506950880445 0.375 2.1 2 1 abnormal osteoblast morphology 0.602908281940748 0.881771626800117 0.607506950880445 0.375 2.1 2 1 abnormal level of surface class II molecules 0.614737872596548 0.881771626800117 0.607506950880445 0.375 2.1 2 1 increased circulating estradiol level 0.614737872596548 0.881771626800117 0.607506950880445 0.375 2.1 2 1 decreased circulating triiodothyronine level 0.614737872596548 0.881771626800117 0.607506950880445 0.375 2.1 2 1 impaired behavioral response to addictive substance 0.614737872596548 0.881771626800117 0.607506950880445 0.375 2.1 2 1 syndactyly 0.603749237576359 0.881771626800117 0.604074708220103 0.372881355932203 2.1 2 1 abnormal blood circulation 0.608130509048296 0.881771626800117 0.602797594672069 0.372093023255814 2.1 2 1 abnormal axon guidance 0.608130509048296 0.881771626800117 0.602797594672069 0.372093023255814 2.1 2 1 abnormal artery morphology 0.612381138114094 0.881771626800117 0.601721170395869 0.371428571428571 2.1 2 1 abnormal action potential 0.614319852535198 0.881771626800117 0.601721170395869 0.371428571428571 2.1 2 1 impaired branching involved in ureteric bud morphogenesis 0.626571051612375 0.884340862363072 0.596848934198332 0.368421052631579 2.1 2 1 decreased grooming behavior 0.631873116019866 0.885013725281203 0.596848934198332 0.368421052631579 2.1 2 1 maternal imprinting 0.631873116019866 0.885013725281203 0.596848934198332 0.368421052631579 2.1 2 1 decreased liver regeneration 0.631873116019866 0.885013725281203 0.596848934198332 0.368421052631579 2.1 2 1 abnormal behavioral response to xenobiotic 0.631873116019866 0.885013725281203 0.596848934198332 0.368421052631579 2.1 2 1 decreased urine osmolality 0.634180856256704 0.887995992084747 0.595108849842068 0.36734693877551 2.1 2 1 abnormal circulating lipid level 0.647017101710614 0.896382645783989 0.589097649338613 0.363636363636364 2.1 2 1 abnormal basement membrane morphology 0.647017101710614 0.896382645783989 0.589097649338613 0.363636363636364 2.1 2 1 abnormal middle ear ossicle morphology 0.647875744731155 0.897322335756541 0.589097649338613 0.363636363636364 2.1 2 1 abnormal food intake 0.672598986430397 0.924614522655769 0.586963237565647 0.36231884057971 2.1 2 1 increased systemic arterial blood pressure 0.663447815070581 0.915068721922967 0.585964151203833 0.361702127659574 2.1 2 1 abnormal inner ear vestibule morphology 0.660641374956964 0.9114505935693 0.583206672845227 0.36 2.1 2 1 abnormal feces composition 0.660641374956964 0.9114505935693 0.583206672845227 0.36 2.1 2 1 impaired conditioned place preference behavior 0.660641374956964 0.9114505935693 0.583206672845227 0.36 2.1 2 1 abnormal vibrissa morphology 0.682926771869655 0.937045710951067 0.578578048457567 0.357142857142857 2.1 2 1 abnormal vasoconstriction 0.671370122866539 0.923180309911838 0.578578048457566 0.357142857142857 2.1 2 1 absent atrioventricular cushions 0.671370122866539 0.923180309911838 0.578578048457566 0.357142857142857 2.1 2 1 abnormal zigzag hair morphology 0.671370122866539 0.923180309911838 0.578578048457566 0.357142857142857 2.1 2 1 megacephaly 0.671370122866539 0.923180309911838 0.578578048457566 0.357142857142857 2.1 2 1 abnormal placing response 0.671370122866539 0.923180309911838 0.578578048457566 0.357142857142857 2.1 2 1 abnormal voluntary movement 0.671370122866539 0.923180309911838 0.578578048457566 0.357142857142857 2.1 2 1 abnormal imprinting 0.671370122866539 0.923180309911838 0.578578048457566 0.357142857142857 2.1 2 1 enlarged stomach 0.671370122866539 0.923180309911838 0.578578048457566 0.357142857142857 2.1 2 1 abnormal pancreas development 0.671370122866539 0.923180309911838 0.578578048457566 0.357142857142857 2.1 2 1 increased circulating growth hormone level 0.671370122866539 0.923180309911838 0.578578048457566 0.357142857142857 2.1 2 1 decreased cornea thickness 0.671370122866539 0.923180309911838 0.578578048457566 0.357142857142857 2.1 2 1 abnormal stria vascularis morphology 0.673058315030154 0.924734912254906 0.578578048457566 0.357142857142857 2.1 2 1 abnormal jaw morphology 0.673058315030154 0.924734912254906 0.578578048457566 0.357142857142857 2.1 2 1 distended urinary bladder 0.682960351338406 0.937045710951067 0.571771247887478 0.352941176470588 2.1 2 1 abnormal heart rate 0.682960351338406 0.937045710951067 0.571771247887478 0.352941176470588 2.1 2 1 abnormal glutamate-mediated receptor currents 0.682960351338406 0.937045710951067 0.571771247887478 0.352941176470588 2.1 2 1 decreased vasoconstriction 0.682960351338406 0.937045710951067 0.571771247887478 0.352941176470588 2.1 2 1 short maxilla 0.695086418009933 0.951845562785417 0.571771247887478 0.352941176470588 2.1 2 1 abnormal pancreatic beta cell physiology 0.704978435809426 0.964860445158706 0.569195701725822 0.351351351351351 2.1 2 1 abnormal hearing physiology 0.693712821703353 0.950226125543552 0.567006487488415 0.35 2.1 2 1 abnormal trachea morphology 0.693712821703353 0.950226125543552 0.567006487488415 0.35 2.1 2 1 abnormal male reproductive system physiology 0.693712821703353 0.950226125543552 0.567006487488415 0.35 2.1 2 1 abnormal heart right ventricle morphology 0.693712821703353 0.950226125543552 0.567006487488415 0.35 2.1 2 1 kidney atrophy 0.693712821703353 0.950226125543552 0.567006487488415 0.35 2.1 2 1 decreased circulating VLDL cholesterol level 0.693712821703353 0.950226125543552 0.567006487488415 0.35 2.1 2 1 abnormal retinal cone cell morphology 0.703740422757323 0.963431096097326 0.563484708063021 0.347826086956522 2.1 2 1 abnormal ureter morphology 0.713136660676822 0.975757669655443 0.560775646966564 0.346153846153846 2.1 2 1 absent long term depression 0.721978055984711 0.98038086753301 0.558627081269375 0.344827586206897 2.1 2 1 abnormal cholesterol homeostasis 0.75290421164393 0.98038086753301 0.553177060964307 0.341463414634146 2.1 2 1 abnormal digestive system physiology 0.772504379577454 0.990773211755048 0.550806302131603 0.34 2.1 2 1 decreased chondrocyte number 0.737613973099562 0.98038086753301 0.540006178560395 0.333333333333333 2.1 2 1 abnormal heart shape 0.742718986566117 0.98038086753301 0.540006178560395 0.333333333333333 2.1 2 1 abnormal mitral valve morphology 0.742718986566117 0.98038086753301 0.540006178560395 0.333333333333333 2.1 2 1 abnormal stomach glandular epithelium morphology 0.742718986566117 0.98038086753301 0.540006178560395 0.333333333333333 2.1 2 1 wrinkled skin 0.760019901950422 0.98038086753301 0.540006178560395 0.333333333333333 2.1 2 1 acidosis 0.742718986566117 0.98038086753301 0.540006178560395 0.333333333333333 2.1 2 1 dry skin 0.748335358877346 0.98038086753301 0.540006178560395 0.333333333333333 2.1 2 1 decreased aggression towards males 0.737613973099562 0.98038086753301 0.540006178560395 0.333333333333333 2.1 2 1 abnormal Muller cell morphology 0.737613973099562 0.98038086753301 0.540006178560395 0.333333333333333 2.1 2 1 abnormal secondary palate development 0.737613973099562 0.98038086753301 0.540006178560395 0.333333333333333 2.1 2 1 herniated liver 0.737613973099562 0.98038086753301 0.540006178560395 0.333333333333333 2.1 2 1 delayed eyelid opening 0.765835733111656 0.982473639048604 0.540006178560395 0.333333333333333 2.1 2 1 emphysema 0.765835733111656 0.982473639048604 0.540006178560395 0.333333333333333 2.1 2 1 abnormal pain threshold 0.765835733111656 0.982473639048604 0.540006178560395 0.333333333333333 2.1 2 1 increased insulin secretion 0.811783888399751 1 0.525411416977682 0.324324324324324 2.1 2 1 decreased circulating progesterone level 0.801212232596866 1 0.52072024361181 0.321428571428571 2.1 2 1 abnormal basisphenoid bone morphology 0.795617212221821 1 0.515460443171286 0.318181818181818 2.1 2 1 intestinal ulcer 0.795617212221821 1 0.515460443171286 0.318181818181818 2.1 2 1 abnormal channel response 0.795617212221821 1 0.515460443171286 0.318181818181818 2.1 2 1 abnormal nail morphology 0.793878619125926 1 0.511584800741427 0.315789473684211 2.1 2 1 impaired behavioral response to xenobiotic 0.840156216939045 1 0.509148682642659 0.314285714285714 2.1 2 1 abnormal epididymis epithelium morphology 0.793466746055478 1 0.506255792400371 0.3125 2.1 2 1 abnormal wound healing 0.793466746055478 1 0.506255792400371 0.3125 2.1 2 1 decreased circulating growth hormone level 0.793466746055478 1 0.506255792400371 0.3125 2.1 2 1 decreased skeletal muscle weight 0.793466746055478 1 0.506255792400371 0.3125 2.1 2 1 abnormal inhibitory postsynaptic currents 0.915167202973662 1 0.500299841901543 0.308823529411765 2.1 2 1 blistering 0.835813307612539 1 0.493049119555144 0.304347826086957 2.1 2 1 abnormal basioccipital bone morphology 0.836806818021314 1 0.486005560704356 0.3 2.1 2 1 decreased paired-pulse facilitation 0.836806818021314 1 0.486005560704356 0.3 2.1 2 1 abnormal heart electrocardiography waveform feature 0.836806818021314 1 0.486005560704356 0.3 2.1 2 1 abnormal single cell response 0.867925344911975 1 0.480005492053685 0.296296296296296 2.1 2 1 abnormal urinary bladder morphology 0.839511077187591 1 0.476476039906231 0.294117647058824 2.1 2 1 enlarged sebaceous gland 0.839511077187591 1 0.476476039906231 0.294117647058824 2.1 2 1 increased aggression towards mice 0.839511077187591 1 0.476476039906231 0.294117647058824 2.1 2 1 abnormal body temperature homeostasis 0.892974766901189 1 0.470327961971957 0.290322580645161 2.1 2 1 abnormal intestine physiology 0.892974766901189 1 0.470327961971957 0.290322580645161 2.1 2 1 hypoalgesia 0.872195401678902 1 0.462862438766053 0.285714285714286 2.1 2 1 abnormal bile salt homeostasis 0.872195401678902 1 0.462862438766053 0.285714285714286 2.1 2 1 delayed kidney development 0.876738804349697 1 0.450005148800329 0.277777777777778 2.1 2 1 abnormal reflex 0.930045940947057 1 0.450005148800329 0.277777777777778 2.1 2 1 decreased heart rate variability 0.876738804349697 1 0.450005148800329 0.277777777777778 2.1 2 1 abnormal metanephric mesenchyme morphology 0.876738804349697 1 0.450005148800329 0.277777777777778 2.1 2 1 single kidney 0.931989449979446 1 0.44182323700396 0.272727272727273 2.1 2 1 abnormal tracheal cartilage morphology 0.900912222725307 1 0.44182323700396 0.272727272727273 2.1 2 1 increased percent body fat/body weight 0.967735116615692 1 0.43615883652955 0.269230769230769 2.1 2 1 flaky skin 0.9063317276439 1 0.426320667284523 0.263157894736842 2.1 2 1 abnormal ear morphology 0.9063317276439 1 0.426320667284523 0.263157894736842 2.1 2 1 osteoarthritis 0.9063317276439 1 0.426320667284523 0.263157894736842 2.1 2 1 increased susceptibility to age related obesity 0.923888310412166 1 0.422613531047266 0.260869565217391 2.1 2 1 abnormal crista ampullaris morphology 0.923888310412166 1 0.422613531047266 0.260869565217391 2.1 2 1 abnormal hepatocyte physiology 0.923888310412166 1 0.422613531047266 0.260869565217391 2.1 2 1 abnormal circulating cytokine level 0.929506697518096 1 0.405004633920297 0.25 2.1 2 1 abnormal tectorial membrane morphology 0.967166416955405 1 0.373850431311043 0.230769230769231 2.1 2 1 decreased cardiac output 0.961094199450943 1 0.368186030836633 0.227272727272727 2.1 2 1 decreased cellular sensitivity to ionizing radiation 6.05685348929429e-06 0.00020088564072826 2.79845482028888 1 20.1 20 1 decreased cardiomyocyte apoptosis 8.74981099551016e-05 0.00172739324216917 2.79845482028888 1 20.1 20 1 abnormal intestinal enteroendocrine cell morphology 0.000332522228958782 0.00526056092509962 2.79845482028888 1 20.1 20 1 abnormal respiratory epithelium morphology 0.000332522228958782 0.00526056092509962 2.79845482028888 1 20.1 20 1 increased cardiac cell glucose uptake 0.000332522228958782 0.00526056092509962 2.79845482028888 1 20.1 20 1 decreased sensitivity to skin irradiation 0.00126359192068709 0.01479145836569 2.79845482028888 1 20.1 20 1 gastric polyps 0.00126359192068709 0.01479145836569 2.79845482028888 1 20.1 20 1 ischuria 0.00126359192068709 0.01479145836569 2.79845482028888 1 20.1 20 1 inlet ventricular septal defect 0.00126359192068709 0.01479145836569 2.79845482028888 1 20.1 20 1 increased Schwann cell number 0.00126359192068709 0.01479145836569 2.79845482028888 1 20.1 20 1 pale lung 0.00126359192068709 0.01479145836569 2.79845482028888 1 20.1 20 1 reduced sympathetic cervical ganglion size 1.33357722082696e-05 0.000387985185591469 2.54404983662626 0.909090909090909 20.1 20 1 colon polyps 0.000538831713597965 0.0076372871086891 2.44864796775277 0.875 20.1 20 1 abnormal extraembryonic tissue physiology 0.000538831713597965 0.0076372871086891 2.44864796775277 0.875 20.1 20 1 stomach epithelial hyperplasia 0.000538831713597965 0.0076372871086891 2.44864796775277 0.875 20.1 20 1 mammary gland hyperplasia 0.00180266694298086 0.0197104792117138 2.39867556024761 0.857142857142857 20.1 20 1 abnormal tumor incidence 0.00180266694298086 0.0197104792117138 2.39867556024761 0.857142857142857 20.1 20 1 altered tumor susceptibility 6.09300050789861e-05 0.00133536024347117 2.33204568357407 0.833333333333333 20.1 20 1 hematuria 6.09300050789861e-05 0.00133536024347117 2.33204568357407 0.833333333333333 20.1 20 1 decreased red blood cell distribution width 6.09300050789861e-05 0.00133536024347117 2.33204568357407 0.833333333333333 20.1 20 1 abnormal hippocampal fimbria morphology 0.00591894037932861 0.0485919610349172 2.33204568357407 0.833333333333333 20.1 20 1 abnormal heart left atrium morphology 0.00591894037932861 0.0485919610349172 2.33204568357407 0.833333333333333 20.1 20 1 abnormal eyelid development 0.00591894037932861 0.0485919610349172 2.33204568357407 0.833333333333333 20.1 20 1 increased transitional stage T1 B cell number 0.00591894037932861 0.0485919610349172 2.33204568357407 0.833333333333333 20.1 20 1 abnormal heart right ventricle outflow tract morphology 0.00591894037932861 0.0485919610349172 2.33204568357407 0.833333333333333 20.1 20 1 delayed limb development 0.00591894037932861 0.0485919610349172 2.33204568357407 0.833333333333333 20.1 20 1 abnormal hair medulla 0.000194244001231427 0.00339075054781175 2.28964485296363 0.818181818181818 20.1 20 1 abnormal gas homeostasis 0.000608797789334282 0.00823035054874471 2.23876385623111 0.8 20.1 20 1 abnormal respiratory conducting tube morphology 0.000608797789334282 0.00823035054874471 2.23876385623111 0.8 20.1 20 1 decreased transitional stage T2 B cell number 0.000608797789334282 0.00823035054874471 2.23876385623111 0.8 20.1 20 1 delayed intramembranous bone ossification 2.18190478554281e-05 0.000571314542530288 2.2387638562311 0.8 20.1 20 1 increased hemangioma incidence 6.68213431599964e-05 0.00141462205200418 2.19878593022698 0.785714285714286 20.1 20 1 distorted hair follicle pattern 0.00186914536169826 0.0201277016762962 2.1765759713358 0.777777777777778 20.1 20 1 abnormal germ cell morphology 0.00186914536169826 0.0201277016762962 2.1765759713358 0.777777777777778 20.1 20 1 genetic imprinting 0.00186914536169826 0.0201277016762962 2.1765759713358 0.777777777777778 20.1 20 1 short frontal bone 0.00186914536169826 0.0201277016762962 2.1765759713358 0.777777777777778 20.1 20 1 disorganized yolk sac vascular plexus 6.62121817708429e-05 0.00141462205200418 2.09884111521666 0.75 20.1 20 1 increased sensitivity to skin irradiation 0.00559417263112958 0.0465401485616549 2.09884111521666 0.75 20.1 20 1 absent eyelids 0.00559417263112958 0.0465401485616549 2.09884111521666 0.75 20.1 20 1 abnormal pulmonary circulation 0.00559417263112958 0.0465401485616549 2.09884111521666 0.75 20.1 20 1 early eyelid opening 0.00559417263112958 0.0465401485616549 2.09884111521666 0.75 20.1 20 1 binucleate 0.00559417263112958 0.0465401485616549 2.09884111521666 0.75 20.1 20 1 increased left ventricle systolic pressure 0.00559417263112958 0.0465401485616549 2.09884111521666 0.75 20.1 20 1 tau protein deposits 0.00559417263112958 0.0465401485616549 2.09884111521666 0.75 20.1 20 1 abnormal cerebellum deep nucleus morphology 0.00559417263112958 0.0465401485616549 2.09884111521666 0.75 20.1 20 1 myocardial trabeculae hypoplasia 0.00559417263112958 0.0465401485616549 2.09884111521666 0.75 20.1 20 1 abnormal bronchiole epithelium morphology 0.00559417263112958 0.0465401485616549 2.09884111521666 0.75 20.1 20 1 lethality during fetal growth through weaning, incomplete penetrance 0.00559417263112958 0.0465401485616549 2.09884111521666 0.75 20.1 20 1 abnormal umbilical vein topology 0.00559417263112958 0.0465401485616549 2.09884111521666 0.75 20.1 20 1 interstitial pneumonia 0.00059418598968875 0.00816595386381638 2.09884111521666 0.75 20.1 20 1 increased osteosarcoma incidence 0.00059418598968875 0.00816595386381638 2.09884111521666 0.75 20.1 20 1 pale placenta 0.00059418598968875 0.00816595386381638 2.09884111521666 0.75 20.1 20 1 increased thymocyte apoptosis 8.48411602946976e-07 3.47614994284741e-05 2.04502467636495 0.730769230769231 20.1 20 1 abnormal germ layer development 7.18621316988525e-06 0.000233669349805092 2.035239869301 0.727272727272727 20.1 20 1 abnormal thrombopoiesis 0.00171427455760856 0.0189522576091169 2.035239869301 0.727272727272727 20.1 20 1 delayed hepatic development 0.00171427455760856 0.0189522576091169 2.035239869301 0.727272727272727 20.1 20 1 abnormal keratinocyte physiology 2.37481599918771e-06 8.88324029771344e-05 2.01488747060799 0.72 20.1 20 1 increased fibroblast apoptosis 9.4857227700884e-08 5.82610750385059e-06 2.01138940208263 0.71875 20.1 20 1 multiple persisting craniopharyngeal ducts 0.000537236828294986 0.0076372871086891 1.99889630020634 0.714285714285714 20.1 20 1 failure of atrioventricular cushion closure 0.016209623970198 0.102468715694708 1.99889630020634 0.714285714285714 20.1 20 1 absent hair follicles 0.016209623970198 0.102468715694708 1.99889630020634 0.714285714285714 20.1 20 1 absent epidermis stratum corneum 0.016209623970198 0.102468715694708 1.99889630020634 0.714285714285714 20.1 20 1 abnormal axial mesoderm 0.016209623970198 0.102468715694708 1.99889630020634 0.714285714285714 20.1 20 1 decreased mortality induced by ionizing radiation 0.016209623970198 0.102468715694708 1.99889630020634 0.714285714285714 20.1 20 1 aorta coarctation 0.016209623970198 0.102468715694708 1.99889630020634 0.714285714285714 20.1 20 1 anuria 0.016209623970198 0.102468715694708 1.99889630020634 0.714285714285714 20.1 20 1 abnormal strial marginal cell morphology 0.016209623970198 0.102468715694708 1.99889630020634 0.714285714285714 20.1 20 1 abnormal sperm annulus morphology 0.016209623970198 0.102468715694708 1.99889630020634 0.714285714285714 20.1 20 1 arteritis 0.016209623970198 0.102468715694708 1.99889630020634 0.714285714285714 20.1 20 1 abnormal retina inner limiting membrane morphology 0.016209623970198 0.102468715694708 1.99889630020634 0.714285714285714 20.1 20 1 decreased skeletal muscle glycogen level 0.016209623970198 0.102468715694708 1.99889630020634 0.714285714285714 20.1 20 1 coronary fistula 0.016209623970198 0.102468715694708 1.99889630020634 0.714285714285714 20.1 20 1 increased compact bone volume 0.016209623970198 0.102468715694708 1.99889630020634 0.714285714285714 20.1 20 1 embryonic lethality at implantation, incomplete penetrance 0.016209623970198 0.102468715694708 1.99889630020634 0.714285714285714 20.1 20 1 embryo tumor 0.016209623970198 0.102468715694708 1.99889630020634 0.714285714285714 20.1 20 1 abnormal embryonic-extraembryonic boundary morphology 0.000170903938138644 0.00309180760814455 1.97537987314509 0.705882352941177 20.1 20 1 abnormal ductus venosus valve morphology 0.000170903938138644 0.00309180760814455 1.97537987314509 0.705882352941177 20.1 20 1 increased skin tumor incidence 5.49521766811275e-05 0.00124266854085732 1.95891837420222 0.7 20.1 20 1 abnormal mammary gland physiology 0.00480995636388088 0.04140057596939 1.95891837420222 0.7 20.1 20 1 abnormal respiratory mechanics 0.00480995636388088 0.04140057596939 1.95891837420222 0.7 20.1 20 1 ketoaciduria 0.00480995636388088 0.04140057596939 1.95891837420222 0.7 20.1 20 1 impaired basement membrane formation 0.00480995636388088 0.04140057596939 1.95891837420222 0.7 20.1 20 1 osteosclerosis 0.00480995636388088 0.04140057596939 1.95891837420222 0.7 20.1 20 1 abnormal cardiovascular development 1.78114914265624e-05 0.000495040055012001 1.9467511793314 0.695652173913043 20.1 20 1 absent teeth 0.00147834648964881 0.0169464833778867 1.93739179866153 0.692307692307692 20.1 20 1 tracheoesophageal fistula 0.00147834648964881 0.0169464833778867 1.93739179866153 0.692307692307692 20.1 20 1 empty decidua capsularis 0.00147834648964881 0.0169464833778867 1.93739179866153 0.692307692307692 20.1 20 1 increased mortality induced by gamma-irradiation 1.90410115466777e-06 7.23122385074212e-05 1.92996884157854 0.689655172413793 20.1 20 1 abnormal hair follicle orientation 0.000464181696896334 0.00679207041782136 1.92393768894861 0.6875 20.1 20 1 increased intestinal adenocarcinoma incidence 0.000464181696896334 0.00679207041782136 1.92393768894861 0.6875 20.1 20 1 blepharitis 0.000464181696896334 0.00679207041782136 1.92393768894861 0.6875 20.1 20 1 increased liver adenoma incidence 0.000147858178311158 0.00274475536230601 1.91473224546081 0.684210526315789 20.1 20 1 embryonic lethality between implantation and somite formation, incomplete penetrance 0.000147858178311158 0.00274475536230601 1.91473224546081 0.684210526315789 20.1 20 1 small superior cervical ganglion 5.03709899917435e-06 0.000169321402168192 1.89895148519603 0.678571428571429 20.1 20 1 embryonic lethality between somite formation and embryo turning, complete penetrance 1.03232017274671e-12 1.65670737400479e-10 1.87896252219396 0.671428571428571 20.1 20 1 abnormal cell adhesion 6.28574590392767e-10 5.39165273655865e-08 1.86563654685925 0.666666666666667 20.1 20 1 microcephaly 2.65233712681084e-12 3.99859915329816e-10 1.86563654685925 0.666666666666667 20.1 20 1 decreased cellular sensitivity to gamma-irradiation 0.000389505010375528 0.00598082539079708 1.86563654685925 0.666666666666667 20.1 20 1 abnormal hypoglossal nerve topology 0.000389505010375528 0.00598082539079708 1.86563654685925 0.666666666666667 20.1 20 1 abnormal bronchus morphology 0.00123055517438984 0.0146810839150826 1.86563654685925 0.666666666666667 20.1 20 1 abnormal coronary vessel morphology 0.00123055517438984 0.0146810839150826 1.86563654685925 0.666666666666667 20.1 20 1 heterochrony 0.00123055517438984 0.0146810839150826 1.86563654685925 0.666666666666667 20.1 20 1 abnormal superior cervical ganglion morphology 0.00395445169344819 0.0368123644792571 1.86563654685925 0.666666666666667 20.1 20 1 increased growth rate 0.00395445169344819 0.0368123644792571 1.86563654685925 0.666666666666667 20.1 20 1 abnormal rostral-caudal body axis extension 0.00395445169344819 0.0368123644792571 1.86563654685925 0.666666666666667 20.1 20 1 decreased mammary gland epithelial cell proliferation 0.00395445169344819 0.0368123644792571 1.86563654685925 0.666666666666667 20.1 20 1 persistent right dorsal aorta 0.00395445169344819 0.0368123644792571 1.86563654685925 0.666666666666667 20.1 20 1 abnormal pulmonary valve cusp morphology 0.00395445169344819 0.0368123644792571 1.86563654685925 0.666666666666667 20.1 20 1 prenatal growth retardation 0.00395445169344819 0.0368123644792571 1.86563654685925 0.666666666666667 20.1 20 1 heart hyperplasia 0.0130442271699922 0.0879638980256824 1.86563654685925 0.666666666666667 20.1 20 1 dilated uterus 0.0130442271699922 0.0879638980256824 1.86563654685925 0.666666666666667 20.1 20 1 decreased level of surface class I molecules 0.0130442271699922 0.0879638980256824 1.86563654685925 0.666666666666667 20.1 20 1 abnormal posterior semicircular canal morphology 0.0130442271699922 0.0879638980256824 1.86563654685925 0.666666666666667 20.1 20 1 premature bone ossification 0.0130442271699922 0.0879638980256824 1.86563654685925 0.666666666666667 20.1 20 1 abnormal thymus physiology 0.0130442271699922 0.0879638980256824 1.86563654685925 0.666666666666667 20.1 20 1 increased neuronal precursor cell number 0.0130442271699922 0.0879638980256824 1.86563654685925 0.666666666666667 20.1 20 1 abnormal gallbladder physiology 0.0130442271699922 0.0879638980256824 1.86563654685925 0.666666666666667 20.1 20 1 positive geotaxis 0.0130442271699922 0.0879638980256824 1.86563654685925 0.666666666666667 20.1 20 1 decreased transitional stage T1 B cell number 0.0130442271699922 0.0879638980256824 1.86563654685925 0.666666666666667 20.1 20 1 abnormal cerebellar layer morphology 0.0130442271699922 0.0879638980256824 1.86563654685925 0.666666666666667 20.1 20 1 abnormal incisor color 0.0130442271699922 0.0879638980256824 1.86563654685925 0.666666666666667 20.1 20 1 abnormal heart left ventricle pressure 0.0130442271699922 0.0879638980256824 1.86563654685925 0.666666666666667 20.1 20 1 increased myeloid cell number 0.0130442271699922 0.0879638980256824 1.86563654685925 0.666666666666667 20.1 20 1 trigeminal neuroma 0.0130442271699922 0.0879638980256824 1.86563654685925 0.666666666666667 20.1 20 1 abnormal infrahyoid muscle connection 0.0130442271699922 0.0879638980256824 1.86563654685925 0.666666666666667 20.1 20 1 symmetric azygos veins 0.0130442271699922 0.0879638980256824 1.86563654685925 0.666666666666667 20.1 20 1 abnormal vagus nerve morphology 0.0010018575879521 0.0126183329115486 1.81076488371634 0.647058823529412 20.1 20 1 abnormal dorsal-ventral axis patterning 0.0010018575879521 0.0126183329115486 1.81076488371634 0.647058823529412 20.1 20 1 abnormal cranial suture morphology 0.0010018575879521 0.0126183329115486 1.81076488371634 0.647058823529412 20.1 20 1 increased brain size 0.0010018575879521 0.0126183329115486 1.81076488371634 0.647058823529412 20.1 20 1 delayed heart development 0.0010018575879521 0.0126183329115486 1.81076488371634 0.647058823529412 20.1 20 1 pale kidney 9.095284694541e-06 0.000288210454492621 1.80545472276702 0.645161290322581 20.1 20 1 abnormal mitotic spindle morphology 2.76751086907541e-05 0.000695372049174251 1.79900667018571 0.642857142857143 20.1 20 1 irregularly shaped pupil 0.00317234388008569 0.03094590353613 1.79900667018571 0.642857142857143 20.1 20 1 abnormal adrenal gland secretion 0.00317234388008569 0.03094590353613 1.79900667018571 0.642857142857143 20.1 20 1 increased lactate dehydrogenase level 0.00317234388008569 0.03094590353613 1.79900667018571 0.642857142857143 20.1 20 1 vascular smooth muscle hypoplasia 0.00317234388008569 0.03094590353613 1.79900667018571 0.642857142857143 20.1 20 1 split sternum 0.00317234388008569 0.03094590353613 1.79900667018571 0.642857142857143 20.1 20 1 decreased cornea thickness 0.00317234388008569 0.03094590353613 1.79900667018571 0.642857142857143 20.1 20 1 increased embryonic tissue cell apoptosis 2.86033831326529e-12 4.18534797308671e-10 1.79388129505698 0.641025641025641 20.1 20 1 increased hepatocyte apoptosis 8.20699696315323e-07 3.40248415764061e-05 1.79388129505698 0.641025641025641 20.1 20 1 spontaneous skin ulceration 8.45757409829032e-05 0.0016898165116062 1.79101108498488 0.64 20.1 20 1 abnormal preimplantation embryo development 8.45757409829032e-05 0.0016898165116062 1.79101108498488 0.64 20.1 20 1 loss of cortex neurons 0.0102273995248575 0.0749356592579762 1.78083488563838 0.636363636363636 20.1 20 1 increased motor neuron number 0.0102273995248575 0.0749356592579762 1.78083488563838 0.636363636363636 20.1 20 1 increased glycogen level 0.0102273995248575 0.0749356592579762 1.78083488563838 0.636363636363636 20.1 20 1 decreased embryonic cilium length 0.0102273995248575 0.0749356592579762 1.78083488563838 0.636363636363636 20.1 20 1 hypolactation 0.0102273995248575 0.0749356592579762 1.78083488563838 0.636363636363636 20.1 20 1 thin hypoglossal nerve 0.0102273995248575 0.0749356592579762 1.78083488563838 0.636363636363636 20.1 20 1 abnormal cell differentiation 6.73670165279566e-07 2.88923195884986e-05 1.77462988603685 0.634146341463415 20.1 20 1 thick interventricular septum 6.84623820418441e-05 0.00143109391032846 1.76199007203374 0.62962962962963 20.1 20 1 abnormal trophoblast layer morphology 5.05368607587608e-08 3.26520626330954e-06 1.75589322057342 0.627450980392157 20.1 20 1 abnormal cell cycle 3.20032068177357e-16 6.92243277905369e-14 1.75207606139826 0.626086956521739 20.1 20 1 lethality throughout fetal growth and development, incomplete penetrance 2.22855852356907e-24 9.23923221229676e-22 1.75098849090701 0.625698324022346 20.1 20 1 failure of primitive streak formation 1.82394823760859e-05 0.000498579257258391 1.74903426268055 0.625 20.1 20 1 abnormal spongiotrophoblast layer morphology 1.82394823760859e-05 0.000498579257258391 1.74903426268055 0.625 20.1 20 1 vasculature congestion 0.00250784430354569 0.0257779450622723 1.74903426268055 0.625 20.1 20 1 kidney degeneration 0.00250784430354569 0.0257779450622723 1.74903426268055 0.625 20.1 20 1 increased heart left ventricle size 0.00250784430354569 0.0257779450622723 1.74903426268055 0.625 20.1 20 1 failure of vascular branching 0.0339020428686453 0.172987346945139 1.74903426268055 0.625 20.1 20 1 abnormal esophageal epithelium morphology 0.0339020428686453 0.172987346945139 1.74903426268055 0.625 20.1 20 1 dry eyes 0.0339020428686453 0.172987346945139 1.74903426268055 0.625 20.1 20 1 poor grooming 0.0339020428686453 0.172987346945139 1.74903426268055 0.625 20.1 20 1 abnormal cellular cholesterol metabolism 0.0339020428686453 0.172987346945139 1.74903426268055 0.625 20.1 20 1 abnormal neuron apoptosis 0.0339020428686453 0.172987346945139 1.74903426268055 0.625 20.1 20 1 liver failure 0.0339020428686453 0.172987346945139 1.74903426268055 0.625 20.1 20 1 abnormal eyelid aperture 0.0339020428686453 0.172987346945139 1.74903426268055 0.625 20.1 20 1 abnormal miscarriage rate 0.0339020428686453 0.172987346945139 1.74903426268055 0.625 20.1 20 1 long femur 0.0339020428686453 0.172987346945139 1.74903426268055 0.625 20.1 20 1 bowed fibula 0.0339020428686453 0.172987346945139 1.74903426268055 0.625 20.1 20 1 abnormal kidney epithelium morphology 0.0339020428686453 0.172987346945139 1.74903426268055 0.625 20.1 20 1 accumulation of giant lysosomes in kidney/renal tubule cells 0.0339020428686453 0.172987346945139 1.74903426268055 0.625 20.1 20 1 Sertoli cell hypoplasia 0.0339020428686453 0.172987346945139 1.74903426268055 0.625 20.1 20 1 abnormal circulating serum amyloid protein level 0.0339020428686453 0.172987346945139 1.74903426268055 0.625 20.1 20 1 decreased quadriceps weight 0.0339020428686453 0.172987346945139 1.74903426268055 0.625 20.1 20 1 delayed suture closure 0.0339020428686453 0.172987346945139 1.74903426268055 0.625 20.1 20 1 abnormal anterior commissure pars posterior morphology 0.0339020428686453 0.172987346945139 1.74903426268055 0.625 20.1 20 1 decreased lung compliance 0.0339020428686453 0.172987346945139 1.74903426268055 0.625 20.1 20 1 abnormal pulmonary acinus morphology 0.0339020428686453 0.172987346945139 1.74903426268055 0.625 20.1 20 1 abnormal foramen magnum morphology 0.0339020428686453 0.172987346945139 1.74903426268055 0.625 20.1 20 1 abnormal bronchus epithelium morphology 0.0339020428686453 0.172987346945139 1.74903426268055 0.625 20.1 20 1 abnormal macrophage activation involved in immune response 0.0339020428686453 0.172987346945139 1.74903426268055 0.625 20.1 20 1 abnormal heart echocardiography feature 0.0339020428686453 0.172987346945139 1.74903426268055 0.625 20.1 20 1 increased testis apoptosis 0.0339020428686453 0.172987346945139 1.74903426268055 0.625 20.1 20 1 absent hypoglossal canal 0.0339020428686453 0.172987346945139 1.74903426268055 0.625 20.1 20 1 abnormal foregut morphology 0.000208570316769588 0.00360290738169688 1.74903426268055 0.625 20.1 20 1 abnormal lung saccule morphology 0.000208570316769588 0.00360290738169688 1.74903426268055 0.625 20.1 20 1 trabecula carnea hypoplasia 4.45724611058297e-07 2.13219225001445e-05 1.74126077706864 0.622222222222222 20.1 20 1 abnormal myocardial trabeculae morphology 4.45724611058297e-07 2.13219225001445e-05 1.74126077706864 0.622222222222222 20.1 20 1 embryonic lethality at implantation, complete penetrance 0.000638286446885015 0.00855923200337722 1.73237679351216 0.619047619047619 20.1 20 1 increased cellular sensitivity to gamma-irradiation 3.59857861421342e-07 1.75518907899135e-05 1.72670616571016 0.617021276595745 20.1 20 1 liver hypoplasia 9.8162004800966e-08 5.95556065713178e-06 1.7221260432547 0.615384615384615 20.1 20 1 absent myocardial trabeculae 0.00791622001952719 0.0611540288775586 1.7221260432547 0.615384615384615 20.1 20 1 absent hypoglossal nerve 0.00791622001952719 0.0611540288775586 1.7221260432547 0.615384615384615 20.1 20 1 abnormal podocyte morphology 4.38713497776427e-05 0.00102952813747063 1.71518198662867 0.612903225806452 20.1 20 1 renal hypoplasia 1.17094701619112e-05 0.00035093140997294 1.71016683462098 0.611111111111111 20.1 20 1 abnormal eye anterior chamber morphology 0.00196412592414385 0.0209326699842517 1.71016683462098 0.611111111111111 20.1 20 1 increased bone trabecula number 3.14986817663745e-06 0.000113555030280951 1.70637489042005 0.609756097560976 20.1 20 1 embryonic lethality between implantation and placentation, complete penetrance 8.52442800055043e-07 3.47614994284741e-05 1.70340728191497 0.608695652173913 20.1 20 1 lymphoid hyperplasia 0.000131497259038983 0.00250650905639441 1.69906185517539 0.607142857142857 20.1 20 1 subcutaneous edema 0.000131497259038983 0.00250650905639441 1.69906185517539 0.607142857142857 20.1 20 1 enlarged pericardium 3.48301878592168e-05 0.000845269193168798 1.6960332244175 0.606060606060606 20.1 20 1 abnormal epidermis stratum basale morphology 3.48301878592168e-05 0.000845269193168798 1.6960332244175 0.606060606060606 20.1 20 1 increased cardiomyocyte apoptosis 3.48301878592168e-05 0.000845269193168798 1.6960332244175 0.606060606060606 20.1 20 1 decreased hair follicle number 9.31576116986309e-06 0.000293328555823221 1.6938016017538 0.605263157894737 20.1 20 1 seminiferous tubule degeneration 1.04756979636856e-09 8.54370448677637e-08 1.68673989168097 0.602739726027397 20.1 20 1 abnormal vitelline vasculature morphology 2.89340544650068e-14 5.53642003705419e-12 1.67907289217333 0.6 20.1 20 1 abnormal cell proliferation 0.00152879496277859 0.0171687470424909 1.67907289217333 0.6 20.1 20 1 waved hair 0.00152879496277859 0.0171687470424909 1.67907289217333 0.6 20.1 20 1 increased mammary adenocarcinoma incidence 0.00152879496277859 0.0171687470424909 1.67907289217333 0.6 20.1 20 1 dilated vasculature 0.00152879496277859 0.0171687470424909 1.67907289217333 0.6 20.1 20 1 abnormal sperm mitochondrial sheath morphology 0.00152879496277859 0.0171687470424909 1.67907289217333 0.6 20.1 20 1 absent ductus venosus valve 0.00152879496277859 0.0171687470424909 1.67907289217333 0.6 20.1 20 1 abnormal lateral semicircular canal morphology 0.0253956333791592 0.138080083127123 1.67907289217333 0.6 20.1 20 1 abnormal auchene hair morphology 0.0253956333791592 0.138080083127123 1.67907289217333 0.6 20.1 20 1 fused cornea and lens 0.0253956333791592 0.138080083127123 1.67907289217333 0.6 20.1 20 1 aneurysm 0.0253956333791592 0.138080083127123 1.67907289217333 0.6 20.1 20 1 absent CD4-positive, alpha beta T cells 0.0253956333791592 0.138080083127123 1.67907289217333 0.6 20.1 20 1 abnormal pillar cell morphology 0.0253956333791592 0.138080083127123 1.67907289217333 0.6 20.1 20 1 abnormal gonadal fat pad morphology 0.0253956333791592 0.138080083127123 1.67907289217333 0.6 20.1 20 1 abnormal sperm principal piece morphology 0.0253956333791592 0.138080083127123 1.67907289217333 0.6 20.1 20 1 abnormal heart and great artery attachment 0.0253956333791592 0.138080083127123 1.67907289217333 0.6 20.1 20 1 abnormal inferior vena cava valve morphology 0.0253956333791592 0.138080083127123 1.67907289217333 0.6 20.1 20 1 thick aortic valve 0.0253956333791592 0.138080083127123 1.67907289217333 0.6 20.1 20 1 fusion of atlas and odontoid process 0.0253956333791592 0.138080083127123 1.67907289217333 0.6 20.1 20 1 decreased trabecular bone connectivity density 0.0253956333791592 0.138080083127123 1.67907289217333 0.6 20.1 20 1 increased B cell derived lymphoma incidence 5.40913375589612e-07 2.4243640032057e-05 1.67907289217333 0.6 20.1 20 1 abnormal cellular respiration 0.000103610392621833 0.00202937678462056 1.67907289217333 0.6 20.1 20 1 increased cellular sensitivity to ionizing radiation 0.000394562180449615 0.00603983645457488 1.67907289217333 0.6 20.1 20 1 abnormal placenta size 0.00608502693862943 0.0494657010125514 1.67907289217333 0.6 20.1 20 1 decreased thymocyte apoptosis 0.00608502693862943 0.0494657010125514 1.67907289217333 0.6 20.1 20 1 decreased brown adipose tissue mass 0.00608502693862943 0.0494657010125514 1.67907289217333 0.6 20.1 20 1 decreased birth body size 6.65121736117506e-14 1.22554838414244e-11 1.66925375245302 0.596491228070175 20.1 20 1 abnormal placenta labyrinth morphology 5.30901499582053e-10 4.63374554459774e-08 1.6649035006782 0.594936708860759 20.1 20 1 abnormal branching of the mammary ductal tree 2.1697288989135e-05 0.000571132342438872 1.66394610936096 0.594594594594595 20.1 20 1 perimembraneous ventricular septal defect 6.99040453582884e-09 5.11430331849242e-07 1.6628499656789 0.594202898550725 20.1 20 1 decreased circulating fructosamine level 0.000308136327703316 0.00500973277883659 1.65834359720823 0.592592592592593 20.1 20 1 increased skin papilloma incidence 0.00118491573409444 0.0144130948095839 1.65363239380707 0.590909090909091 20.1 20 1 abnormal basement membrane morphology 0.00118491573409444 0.0144130948095839 1.65363239380707 0.590909090909091 20.1 20 1 abnormal sperm midpiece morphology 0.00118491573409444 0.0144130948095839 1.65363239380707 0.590909090909091 20.1 20 1 increased circulating creatine kinase level 0.00118491573409444 0.0144130948095839 1.65363239380707 0.590909090909091 20.1 20 1 increased adenoma incidence 0.00118491573409444 0.0144130948095839 1.65363239380707 0.590909090909091 20.1 20 1 abnormal extraembryonic tissue morphology 4.47406763215139e-12 5.70730422306492e-10 1.64614989428758 0.588235294117647 20.1 20 1 overexpanded pulmonary alveoli 6.365449047214e-05 0.00138288685632706 1.64614989428758 0.588235294117647 20.1 20 1 abnormal bone marrow cavity morphology 0.00465925389725081 0.0413924788193264 1.64614989428758 0.588235294117647 20.1 20 1 increased incidence of corneal inflammation 0.00465925389725081 0.0413924788193264 1.64614989428758 0.588235294117647 20.1 20 1 abnormal cell cytoskeleton morphology 0.00465925389725081 0.0413924788193264 1.64614989428758 0.588235294117647 20.1 20 1 decreased trophoblast giant cell number 0.000239899047647253 0.00401851098331677 1.64047351534176 0.586206896551724 20.1 20 1 atrioventricular septal defect 7.72823076067469e-07 3.23092000288711e-05 1.63683206469727 0.584905660377358 20.1 20 1 embryonic lethality during organogenesis, complete penetrance 1.83064024705569e-58 9.10743522910204e-55 1.63409772541869 0.583928571428571 20.1 20 1 abnormal supraoccipital bone morphology 0.0190095264888304 0.110471732999841 1.63243197850185 0.583333333333333 20.1 20 1 abnormal embryonic growth/weight/body size 0.0190095264888304 0.110471732999841 1.63243197850185 0.583333333333333 20.1 20 1 loss of dopaminergic neurons 0.0190095264888304 0.110471732999841 1.63243197850185 0.583333333333333 20.1 20 1 decreased left ventricle systolic pressure 0.0190095264888304 0.110471732999841 1.63243197850185 0.583333333333333 20.1 20 1 decreased keratinocyte proliferation 0.0190095264888304 0.110471732999841 1.63243197850185 0.583333333333333 20.1 20 1 abnormal vitelline vein connection 0.0190095264888304 0.110471732999841 1.63243197850185 0.583333333333333 20.1 20 1 absent mesoderm 1.66295212470674e-07 9.40134865956365e-06 1.63243197850185 0.583333333333333 20.1 20 1 abnormal trophoblast giant cell morphology 4.96968107249828e-05 0.00114996108538041 1.63243197850185 0.583333333333333 20.1 20 1 decreased circulating total protein level 6.0684719153652e-07 2.69559355169124e-05 1.6281918954408 0.581818181818182 20.1 20 1 increased tumor incidence 8.47017770948669e-14 1.45307358981711e-11 1.62490925049032 0.580645161290323 20.1 20 1 abnormal mitochondrial ATP synthesis coupled electron transport 0.000186325990406096 0.00333734367322968 1.62490925049032 0.580645161290323 20.1 20 1 increased hepatocellular carcinoma incidence 4.75794015362459e-07 2.23308983625305e-05 1.62015805385146 0.578947368421053 20.1 20 1 impaired branching involved in ureteric bud morphogenesis 3.87218897406341e-05 0.000917340006950737 1.62015805385146 0.578947368421053 20.1 20 1 decreased germ cell number 0.00355963357642358 0.033990742884275 1.62015805385146 0.578947368421053 20.1 20 1 increased liver cholesterol level 0.00355963357642358 0.033990742884275 1.62015805385146 0.578947368421053 20.1 20 1 pale yolk sac 1.33697064930608e-09 1.07281112585448e-07 1.61838351052851 0.578313253012048 20.1 20 1 thin ventricular wall 2.91925453888712e-10 2.79294064056989e-08 1.61688500727802 0.577777777777778 20.1 20 1 single kidney 0.000144444689638233 0.00272201640511442 1.61123156319663 0.575757575757576 20.1 20 1 embryonic lethality between implantation and somite formation, complete penetrance 1.74407199377081e-24 7.88796197182709e-22 1.59911704016508 0.571428571428571 20.1 20 1 liver degeneration 0.00271613965063668 0.0274093200038894 1.59911704016508 0.571428571428571 20.1 20 1 abnormal embryonic/fetal subventricular zone morphology 0.00271613965063668 0.0274093200038894 1.59911704016508 0.571428571428571 20.1 20 1 vascular ring 0.00271613965063668 0.0274093200038894 1.59911704016508 0.571428571428571 20.1 20 1 premature aging 0.000543655085922426 0.00764035043068946 1.59911704016507 0.571428571428571 20.1 20 1 increased bone resorption 0.000543655085922426 0.00764035043068946 1.59911704016507 0.571428571428571 20.1 20 1 prolonged QRS complex duration 0.000543655085922426 0.00764035043068946 1.59911704016507 0.571428571428571 20.1 20 1 midline facial cleft 0.0142413882054492 0.0937181300557008 1.59911704016507 0.571428571428571 20.1 20 1 translucent skin 0.0142413882054492 0.0937181300557008 1.59911704016507 0.571428571428571 20.1 20 1 abnormal fluid regulation 0.0142413882054492 0.0937181300557008 1.59911704016507 0.571428571428571 20.1 20 1 abnormal pancreas development 0.0142413882054492 0.0937181300557008 1.59911704016507 0.571428571428571 20.1 20 1 lysosomal protein accumulation 0.0142413882054492 0.0937181300557008 1.59911704016507 0.571428571428571 20.1 20 1 abnormal glucose tolerance 0.0142413882054492 0.0937181300557008 1.59911704016507 0.571428571428571 20.1 20 1 spina bifida occulta 0.0142413882054492 0.0937181300557008 1.59911704016507 0.571428571428571 20.1 20 1 increased stomach tumor incidence 0.0142413882054492 0.0937181300557008 1.59911704016507 0.571428571428571 20.1 20 1 testis degeneration 0.0142413882054492 0.0937181300557008 1.59911704016507 0.571428571428571 20.1 20 1 decreased embryo size 2.11904752549942e-46 3.51408714645321e-43 1.59828068188047 0.571129707112971 20.1 20 1 embryonic lethality, incomplete penetrance 1.81537150561009e-05 0.000498579257258391 1.59003114789141 0.568181818181818 20.1 20 1 abnormal incisor morphology 6.42241779262895e-07 2.80276565950255e-05 1.58579106483037 0.566666666666667 20.1 20 1 muscular ventricular septal defect 6.42241779262895e-07 2.80276565950255e-05 1.58579106483037 0.566666666666667 20.1 20 1 emphysema 0.000418122673449725 0.00632267568514402 1.58579106483037 0.566666666666667 20.1 20 1 liver hemorrhage 0.000418122673449725 0.00632267568514402 1.58579106483037 0.566666666666667 20.1 20 1 abnormal optic cup morphology 0.000418122673449725 0.00632267568514402 1.58579106483037 0.566666666666667 20.1 20 1 abnormal palatal shelf fusion at midline 0.00207115753238388 0.0217843736228537 1.58173533320676 0.565217391304348 20.1 20 1 abnormal iris morphology 6.67718066121988e-05 0.00141462205200418 1.57861553965014 0.564102564102564 20.1 20 1 failure of heart looping 6.67718066121988e-05 0.00141462205200418 1.57861553965014 0.564102564102564 20.1 20 1 abnormal head morphology 2.32552856044613e-06 8.76477620319659e-05 1.57731089870828 0.563636363636364 20.1 20 1 abnormal olfaction 0.0106842617551657 0.0772590148720191 1.5741308364125 0.5625 20.1 20 1 abnormal pulmonary elastic fiber morphology 0.0106842617551657 0.0772590148720191 1.5741308364125 0.5625 20.1 20 1 decreased circulating triiodothyronine level 0.0106842617551657 0.0772590148720191 1.5741308364125 0.5625 20.1 20 1 decreased creatinine clearance 0.0106842617551657 0.0772590148720191 1.5741308364125 0.5625 20.1 20 1 dilated respiratory conducting tubes 0.0106842617551657 0.0772590148720191 1.5741308364125 0.5625 20.1 20 1 double outlet right ventricle 7.03926628065891e-11 7.14701015230165e-09 1.56922700203115 0.560747663551402 20.1 20 1 abnormal vascular development 3.01732619174641e-07 1.51628260645843e-05 1.56883073258619 0.560606060606061 20.1 20 1 abnormal myocardium layer morphology 3.06833033179392e-08 2.00854518429931e-06 1.55863306446469 0.556962025316456 20.1 20 1 small placenta 3.06447098317245e-05 0.000762287157064147 1.55469712238271 0.555555555555556 20.1 20 1 thin epidermis 0.00120353553669313 0.0144977949032647 1.55469712238271 0.555555555555556 20.1 20 1 increased brain weight 0.00120353553669313 0.0144977949032647 1.55469712238271 0.555555555555556 20.1 20 1 abnormal type II pneumocyte morphology 0.00120353553669313 0.0144977949032647 1.55469712238271 0.555555555555556 20.1 20 1 abnormal eye muscle morphology 0.00120353553669313 0.0144977949032647 1.55469712238271 0.555555555555556 20.1 20 1 abnormal uterus morphology 0.000189452475382935 0.00337642251100551 1.55469712238271 0.555555555555556 20.1 20 1 underdeveloped hair follicles 0.00802816386363452 0.0612578454318738 1.55469712238271 0.555555555555556 20.1 20 1 cortical renal glomerulopathies 0.00802816386363452 0.0612578454318738 1.55469712238271 0.555555555555556 20.1 20 1 delayed kidney development 0.00802816386363452 0.0612578454318738 1.55469712238271 0.555555555555556 20.1 20 1 abnormal mammary gland morphology 0.00802816386363452 0.0612578454318738 1.55469712238271 0.555555555555556 20.1 20 1 absent allantois 0.00802816386363452 0.0612578454318738 1.55469712238271 0.555555555555556 20.1 20 1 absent inner cell mass 0.00802816386363452 0.0612578454318738 1.55469712238271 0.555555555555556 20.1 20 1 increased gastrointestinal tumor incidence 0.00802816386363452 0.0612578454318738 1.55469712238271 0.555555555555556 20.1 20 1 increased adipocyte glucose uptake 0.00802816386363452 0.0612578454318738 1.55469712238271 0.555555555555556 20.1 20 1 abnormal urinary bladder urothelium morphology 0.0599743124919617 0.250732945081941 1.55469712238271 0.555555555555556 20.1 20 1 abnormal sympathetic neuron morphology 0.0599743124919617 0.250732945081941 1.55469712238271 0.555555555555556 20.1 20 1 abnormal geniculate ganglion morphology 0.0599743124919617 0.250732945081941 1.55469712238271 0.555555555555556 20.1 20 1 wavy vibrissae 0.0599743124919617 0.250732945081941 1.55469712238271 0.555555555555556 20.1 20 1 increased pheochromocytoma incidence 0.0599743124919617 0.250732945081941 1.55469712238271 0.555555555555556 20.1 20 1 abnormal lens capsule morphology 0.0599743124919617 0.250732945081941 1.55469712238271 0.555555555555556 20.1 20 1 premature neuronal precursor differentiation 0.0599743124919617 0.250732945081941 1.55469712238271 0.555555555555556 20.1 20 1 decreased fear-related response 0.0599743124919617 0.250732945081941 1.55469712238271 0.555555555555556 20.1 20 1 decreased cochlear hair cell number 0.0599743124919617 0.250732945081941 1.55469712238271 0.555555555555556 20.1 20 1 eye opacity 0.0599743124919617 0.250732945081941 1.55469712238271 0.555555555555556 20.1 20 1 iris coloboma 0.0599743124919617 0.250732945081941 1.55469712238271 0.555555555555556 20.1 20 1 abnormal pulmonary alveolar system morphology 0.0599743124919617 0.250732945081941 1.55469712238271 0.555555555555556 20.1 20 1 abnormal pulmonary alveolar parenchyma morphology 0.0599743124919617 0.250732945081941 1.55469712238271 0.555555555555556 20.1 20 1 increased cardiac muscle glycogen level 0.0599743124919617 0.250732945081941 1.55469712238271 0.555555555555556 20.1 20 1 adipose tissue inflammation 0.0599743124919617 0.250732945081941 1.55469712238271 0.555555555555556 20.1 20 1 kidney cysts 1.09306537276224e-07 6.39764732881428e-06 1.55049523826816 0.554054054054054 20.1 20 1 abnormal cell nucleus morphology 2.36150039117779e-05 0.000608728727777695 1.54808138994704 0.553191489361702 20.1 20 1 decreased cell proliferation 9.02227160560697e-17 2.04026369263158e-14 1.54293184686198 0.551351351351351 20.1 20 1 small liver 6.56198588238852e-08 4.13238984365606e-06 1.542737913749 0.551282051282051 20.1 20 1 abnormal vascular regression 0.00604176965976747 0.0493560000941595 1.53915015115888 0.55 20.1 20 1 small lung 1.4009869982868e-05 0.000402884989391724 1.53640656800174 0.549019607843137 20.1 20 1 perinatal lethality, incomplete penetrance 7.91955080633913e-20 2.81426894725266e-17 1.5354353881231 0.548672566371681 20.1 20 1 abnormal postnatal growth/weight/body size 0.000699590074288417 0.00923199103338163 1.53463651435197 0.548387096774194 20.1 20 1 abnormal capillary morphology 0.000699590074288417 0.00923199103338163 1.53463651435197 0.548387096774194 20.1 20 1 decreased thymus weight 0.000699590074288417 0.00923199103338163 1.53463651435197 0.548387096774194 20.1 20 1 enlarged kidney 1.07869137825366e-05 0.000329232491215456 1.53122999600712 0.547169811320755 20.1 20 1 increased body size 0.00455360835048737 0.0407449668051703 1.52642990197575 0.545454545454545 20.1 20 1 intracerebral hemorrhage 0.00455360835048737 0.0407449668051703 1.52642990197575 0.545454545454545 20.1 20 1 increased myocardial infarction size 0.00455360835048737 0.0407449668051703 1.52642990197575 0.545454545454545 20.1 20 1 abnormal vascular branching morphogenesis 0.00455360835048737 0.0407449668051703 1.52642990197575 0.545454545454545 20.1 20 1 abnormal occipital bone morphology 0.00455360835048737 0.0407449668051703 1.52642990197575 0.545454545454545 20.1 20 1 increased mammary gland tumor incidence 0.00455360835048737 0.0407449668051703 1.52642990197575 0.545454545454545 20.1 20 1 increased bone volume 0.00455360835048737 0.0407449668051703 1.52642990197575 0.545454545454545 20.1 20 1 abnormal sphenoid bone morphology 0.0435975140043214 0.210784870914965 1.52642990197575 0.545454545454545 20.1 20 1 abnormal food preference 0.0435975140043214 0.210784870914965 1.52642990197575 0.545454545454545 20.1 20 1 abnormal proximal-distal axis patterning 0.0435975140043214 0.210784870914965 1.52642990197575 0.545454545454545 20.1 20 1 fatigue 0.0435975140043214 0.210784870914965 1.52642990197575 0.545454545454545 20.1 20 1 abnormal radial glial cell morphology 0.0435975140043214 0.210784870914965 1.52642990197575 0.545454545454545 20.1 20 1 pathological neovascularization 0.0435975140043214 0.210784870914965 1.52642990197575 0.545454545454545 20.1 20 1 abnormal palate development 0.0435975140043214 0.210784870914965 1.52642990197575 0.545454545454545 20.1 20 1 decreased palatine bone horizontal plate size 0.0435975140043214 0.210784870914965 1.52642990197575 0.545454545454545 20.1 20 1 increased number of Howell-Jolly bodies 0.0435975140043214 0.210784870914965 1.52642990197575 0.545454545454545 20.1 20 1 aorta dilation 0.0435975140043214 0.210784870914965 1.52642990197575 0.545454545454545 20.1 20 1 decreased core body temperature 0.0435975140043214 0.210784870914965 1.52642990197575 0.545454545454545 20.1 20 1 abnormal placenta morphology 1.07349633455988e-07 6.39764732881428e-06 1.52320958572686 0.544303797468354 20.1 20 1 abnormal embryo development 3.39070614631337e-12 4.6857675216414e-10 1.52268865221601 0.544117647058823 20.1 20 1 embryonic lethality before implantation, complete penetrance 2.54249167165962e-11 2.81086579255703e-09 1.52235942223715 0.544 20.1 20 1 absent vitelline blood vessels 6.39140865917469e-06 0.000210577868075458 1.52196665664834 0.543859649122807 20.1 20 1 embryonic lethality during organogenesis, incomplete penetrance 1.63128589397486e-19 5.41043154834997e-17 1.52089935885265 0.543478260869565 20.1 20 1 failure to gastrulate 5.03748595155762e-05 0.00115490749350227 1.52089935885265 0.543478260869565 20.1 20 1 abnormal nursing 0.00343674479978359 0.0331352817420995 1.51582969432314 0.541666666666667 20.1 20 1 abnormal osteoblast morphology 0.00343674479978359 0.0331352817420995 1.51582969432314 0.541666666666667 20.1 20 1 malocclusion 0.000310636348770762 0.00501758388030695 1.51267828123723 0.540540540540541 20.1 20 1 increased circulating phosphate level 0.000310636348770762 0.00501758388030695 1.51267828123723 0.540540540540541 20.1 20 1 distended pericardium 2.27440065071999e-05 0.000589330376944372 1.50686028784786 0.538461538461538 20.1 20 1 eyelids open at birth 2.27440065071999e-05 0.000589330376944372 1.50686028784786 0.538461538461538 20.1 20 1 ventricular hypoplasia 0.00259712628344244 0.0264768509428815 1.50686028784786 0.538461538461538 20.1 20 1 heart inflammation 0.00259712628344244 0.0264768509428815 1.50686028784786 0.538461538461538 20.1 20 1 increased foot pad pigmentation 0.0319517173696842 0.168389612197224 1.50686028784786 0.538461538461538 20.1 20 1 pup cannibalization 0.0319517173696842 0.168389612197224 1.50686028784786 0.538461538461538 20.1 20 1 abnormal grip strength 0.0319517173696842 0.168389612197224 1.50686028784786 0.538461538461538 20.1 20 1 abnormal soleus morphology 0.0319517173696842 0.168389612197224 1.50686028784786 0.538461538461538 20.1 20 1 absent lateral semicircular canal 0.0319517173696842 0.168389612197224 1.50686028784786 0.538461538461538 20.1 20 1 abnormal aorta tunica media morphology 0.0319517173696842 0.168389612197224 1.50686028784786 0.538461538461538 20.1 20 1 increased urine protein level 2.24511292303259e-07 1.17573018864075e-05 1.50686028784786 0.538461538461538 20.1 20 1 abnormal heart looping 0.000237132289388006 0.00398558493143692 1.50686028784786 0.538461538461538 20.1 20 1 decreased trabecular bone volume 0.000237132289388006 0.00398558493143692 1.50686028784786 0.538461538461538 20.1 20 1 abnormal axon morphology 1.38493139266894e-09 1.07656776226999e-07 1.50287388496995 0.537037037037037 20.1 20 1 increased cell proliferation 1.7449913771869e-05 0.000487715286601394 1.50287388496995 0.537037037037037 20.1 20 1 failure of blastocyst to hatch from the zona pellucida 0.00196493605681318 0.0209326699842517 1.49917222515476 0.535714285714286 20.1 20 1 abnormal renal tubule epithelium morphology 0.00196493605681318 0.0209326699842517 1.49917222515476 0.535714285714286 20.1 20 1 delayed endochondral bone ossification 0.000138320087174486 0.0026165111547265 1.49684792713126 0.534883720930233 20.1 20 1 abnormal embryonic neuroepithelium morphology 1.02740335836209e-05 0.000317474019121206 1.49572585222337 0.53448275862069 20.1 20 1 abnormal brain vasculature morphology 0.00148823552639718 0.0170206246984506 1.4925092374874 0.533333333333333 20.1 20 1 decreased salivation 0.0235629439389575 0.13230885563918 1.4925092374874 0.533333333333333 20.1 20 1 placental labyrinth hypoplasia 0.0235629439389575 0.13230885563918 1.4925092374874 0.533333333333333 20.1 20 1 abnormal pericyte morphology 0.0235629439389575 0.13230885563918 1.4925092374874 0.533333333333333 20.1 20 1 immune system phenotype 0.0235629439389575 0.13230885563918 1.4925092374874 0.533333333333333 20.1 20 1 abnormal energy homeostasis 0.0235629439389575 0.13230885563918 1.4925092374874 0.533333333333333 20.1 20 1 absent chorion 0.0235629439389575 0.13230885563918 1.4925092374874 0.533333333333333 20.1 20 1 bicuspid aortic valve 0.0235629439389575 0.13230885563918 1.4925092374874 0.533333333333333 20.1 20 1 embryonic lethality, complete penetrance 9.76734815612012e-25 4.85925570766976e-22 1.4913395594016 0.532915360501567 20.1 20 1 embryonic growth arrest 3.70855611150362e-18 1.08529803851356e-15 1.49087986059058 0.532751091703057 20.1 20 1 abnormal nervous system morphology 3.5750560775151e-07 1.75518907899135e-05 1.48778610698903 0.531645569620253 20.1 20 1 abnormal tooth morphology 4.64452507094097e-06 0.000158263782383091 1.48667912327847 0.53125 20.1 20 1 abnormal embryonic hematopoiesis 0.00112830003479558 0.0140684026894937 1.48667912327847 0.53125 20.1 20 1 bradykinesia 0.00112830003479558 0.0140684026894937 1.48667912327847 0.53125 20.1 20 1 abnormal long bone hypertrophic chondrocyte zone 6.17645557055509e-05 0.00134771344138209 1.484894394439 0.530612244897959 20.1 20 1 abnormal neural tube closure 2.11603755311911e-07 1.11992413050719e-05 1.48351821798447 0.530120481927711 20.1 20 1 ventricular septal defect 3.68836984694248e-11 3.90417872096571e-09 1.48153490485882 0.529411764705882 20.1 20 1 enlarged liver sinusoidal spaces 0.000856194741974106 0.011121589664024 1.48153490485882 0.529411764705882 20.1 20 1 abnormal endoderm development 0.000856194741974106 0.011121589664024 1.48153490485882 0.529411764705882 20.1 20 1 abnormal interatrial septum morphology 0.0174623955953199 0.109552860134573 1.48153490485882 0.529411764705882 20.1 20 1 increased circulating magnesium level 0.0174623955953199 0.109552860134573 1.48153490485882 0.529411764705882 20.1 20 1 increased hepatoma incidence 0.0174623955953199 0.109552860134573 1.48153490485882 0.529411764705882 20.1 20 1 abnormal coat/ hair morphology 3.61359503588229e-05 0.000864309389592039 1.47842896166205 0.528301886792453 20.1 20 1 abnormal mesoderm development 3.61359503588229e-05 0.000864309389592039 1.47842896166205 0.528301886792453 20.1 20 1 abnormal placenta development 3.61359503588229e-05 0.000864309389592039 1.47842896166205 0.528301886792453 20.1 20 1 abnormal rostral-caudal axis patterning 2.76512904401451e-05 0.000695372049174251 1.47554890524323 0.527272727272727 20.1 20 1 pale liver 1.23904237128624e-06 4.97115790092663e-05 1.4748613242063 0.527027027027027 20.1 20 1 lethality throughout fetal growth and development, complete penetrance 1.05521618661611e-14 2.09988021136606e-12 1.47287095804678 0.526315789473684 20.1 20 1 abnormal stationary movement 0.0129931975160911 0.0879638980256824 1.47287095804678 0.526315789473684 20.1 20 1 abnormal neural crest cell migration 0.0129931975160911 0.0879638980256824 1.47287095804678 0.526315789473684 20.1 20 1 increased susceptibility to ischemic brain injury 0.0129931975160911 0.0879638980256824 1.47287095804678 0.526315789473684 20.1 20 1 absent amnion 0.0129931975160911 0.0879638980256824 1.47287095804678 0.526315789473684 20.1 20 1 decreased susceptibility to weight gain 0.0129931975160911 0.0879638980256824 1.47287095804678 0.526315789473684 20.1 20 1 abnormal craniofacial bone morphology 2.11642272544135e-05 0.000566086185971544 1.47287095804678 0.526315789473684 20.1 20 1 abnormal blood vessel morphology 2.03865597354249e-11 2.41483654008903e-09 1.46677631959969 0.524137931034483 20.1 20 1 trunk curl 0.00969996266981132 0.0717047760509827 1.46585728681799 0.523809523809524 20.1 20 1 left pulmonary isomerism 0.00969996266981132 0.0717047760509827 1.46585728681799 0.523809523809524 20.1 20 1 increased keratinocyte proliferation 0.00969996266981132 0.0717047760509827 1.46585728681799 0.523809523809524 20.1 20 1 abnormal tumor vascularization 0.00969996266981132 0.0717047760509827 1.46585728681799 0.523809523809524 20.1 20 1 complete atrioventricular septal defect 0.00969996266981132 0.0717047760509827 1.46585728681799 0.523809523809524 20.1 20 1 absent segment of posterior cerebral artery 0.00969996266981132 0.0717047760509827 1.46585728681799 0.523809523809524 20.1 20 1 osteoporosis 0.000217893244667457 0.00372515083237319 1.4628286560601 0.522727272727273 20.1 20 1 decreased erythrocyte cell number 4.27269858504034e-12 5.5938619633094e-10 1.46161334562859 0.522292993630573 20.1 20 1 conjunctivitis 0.00726173651569116 0.0567145041845582 1.46006338449855 0.521739130434783 20.1 20 1 abnormal ulna morphology 0.00726173651569116 0.0567145041845582 1.46006338449855 0.521739130434783 20.1 20 1 abnormal hematopoietic stem cell physiology 0.00726173651569116 0.0567145041845582 1.46006338449855 0.521739130434783 20.1 20 1 abnormal vertebral artery topology 0.00726173651569116 0.0567145041845582 1.46006338449855 0.521739130434783 20.1 20 1 pallor 4.09439129988785e-13 6.78986557231402e-11 1.45519650655022 0.52 20.1 20 1 decreased cardiac muscle contractility 2.38263600368904e-08 1.60183974572338e-06 1.45304384899615 0.519230769230769 20.1 20 1 abnormal placenta vasculature 7.36887416983694e-05 0.0015086481067876 1.45304384899615 0.519230769230769 20.1 20 1 kinked neural tube 7.36887416983694e-05 0.0015086481067876 1.45304384899615 0.519230769230769 20.1 20 1 hemorrhage 5.35674096408418e-17 1.4026203313852e-14 1.45281484287338 0.519148936170213 20.1 20 1 abnormal apoptosis 5.62593743755428e-05 0.00126076751134381 1.4510506475572 0.518518518518518 20.1 20 1 abnormal skin appearance 0.00409791631840326 0.0378239957032582 1.4510506475572 0.518518518518518 20.1 20 1 abnormal lung development 5.12133312869976e-07 2.34240301848932e-05 1.44861190697307 0.517647058823529 20.1 20 1 glomerulosclerosis 3.28322919016914e-05 0.000812640060750819 1.4474766311839 0.517241379310345 20.1 20 1 lordosis 0.00308717968394314 0.0305342324604715 1.4474766311839 0.517241379310345 20.1 20 1 small spleen 2.31634182845865e-07 1.18802068005998e-05 1.44535578630305 0.516483516483517 20.1 20 1 increased lung adenoma incidence 0.00232945734197986 0.0242448750551251 1.44436377821362 0.516129032258065 20.1 20 1 abnormal nose morphology 0.00232945734197986 0.0242448750551251 1.44436377821362 0.516129032258065 20.1 20 1 inner cell mass degeneration 0.00232945734197986 0.0242448750551251 1.44436377821362 0.516129032258065 20.1 20 1 abnormal skeleton physiology 0.00176020829595148 0.0193739740538908 1.44162824075488 0.515151515151515 20.1 20 1 myeloid hyperplasia 0.00176020829595148 0.0193739740538908 1.44162824075488 0.515151515151515 20.1 20 1 decreased mean corpuscular hemoglobin 8.59302791891776e-06 0.00027580847675236 1.44038115750163 0.514705882352941 20.1 20 1 abnormal liver development 0.00133175548674568 0.015372351616148 1.43920533614857 0.514285714285714 20.1 20 1 thick pulmonary interalveolar septum 0.00133175548674568 0.015372351616148 1.43920533614857 0.514285714285714 20.1 20 1 increased carcinoma incidence 0.00133175548674568 0.015372351616148 1.43920533614857 0.514285714285714 20.1 20 1 decreased circulating thyroxine level 0.00133175548674568 0.015372351616148 1.43920533614857 0.514285714285714 20.1 20 1 abnormal forebrain development 5.03675454193836e-06 0.000169321402168192 1.43809483820401 0.513888888888889 20.1 20 1 increased granulocyte number 3.85756081448075e-06 0.00013515045811297 1.43704436717537 0.513513513513513 20.1 20 1 small seminiferous tubules 3.85756081448075e-06 0.00013515045811297 1.43704436717537 0.513513513513513 20.1 20 1 abnormal respiratory electron transport chain 0.00100874296908402 0.0126729703818005 1.43704436717537 0.513513513513513 20.1 20 1 acanthosis 0.000764864508016908 0.0100666691200638 1.43510503604558 0.512820512820513 20.1 20 1 abnormal developmental patterning 1.33015802610431e-06 5.24323658940473e-05 1.43335490795284 0.51219512195122 20.1 20 1 abnormal mammary gland development 0.000580490721462901 0.00811219477325262 1.43335490795284 0.51219512195122 20.1 20 1 hemopericardium 0.000580490721462901 0.00811219477325262 1.43335490795284 0.51219512195122 20.1 20 1 abnormal vasculogenesis 0.000440937457139618 0.00654825029632716 1.43176758247338 0.511627906976744 20.1 20 1 abnormal blood circulation 0.000440937457139618 0.00654825029632716 1.43176758247338 0.511627906976744 20.1 20 1 kidney failure 0.000440937457139618 0.00654825029632716 1.43176758247338 0.511627906976744 20.1 20 1 abnormal double-strand DNA break repair 0.000440937457139618 0.00654825029632716 1.43176758247338 0.511627906976744 20.1 20 1 abnormal ectoderm development 0.000335195540353081 0.00526056092509962 1.4303213525921 0.511111111111111 20.1 20 1 albuminuria 0.000335195540353081 0.00526056092509962 1.4303213525921 0.511111111111111 20.1 20 1 abnormal cell migration 0.000335195540353081 0.00526056092509962 1.4303213525921 0.511111111111111 20.1 20 1 decreased hemoglobin content 3.21194314381269e-10 3.01498436612607e-08 1.42899820610496 0.51063829787234 20.1 20 1 pulmonary hypoplasia 0.000254994795994264 0.00424280638819887 1.42899820610496 0.51063829787234 20.1 20 1 increased respiratory quotient 0.000254994795994264 0.00424280638819887 1.42899820610496 0.51063829787234 20.1 20 1 absent kidney 0.000194111704973661 0.00339075054781175 1.42778307157596 0.510204081632653 20.1 20 1 abnormal craniofacial development 0.000194111704973661 0.00339075054781175 1.42778307157596 0.510204081632653 20.1 20 1 decreased circulating creatinine level 0.000194111704973661 0.00339075054781175 1.42778307157596 0.510204081632653 20.1 20 1 prenatal lethality, incomplete penetrance 3.39533964160037e-20 1.29937036284322e-17 1.42684374060782 0.509868421052632 20.1 20 1 failure of chorioallantoic fusion 0.000147855545142491 0.00274475536230601 1.4266632417159 0.509803921568627 20.1 20 1 abnormal facial morphology 6.55545154378952e-05 0.00141183426105424 1.42377525944522 0.508771929824561 20.1 20 1 decreased bone marrow cell number 7.63069949573349e-06 0.000246511233709572 1.41839490891354 0.506849315068493 20.1 20 1 edema 9.4431762767935e-12 1.17449504942619e-09 1.41549749630891 0.505813953488372 20.1 20 1 abnormal craniofacial morphology 1.41355846248433e-07 8.08327971363163e-06 1.41281214228177 0.504854368932039 20.1 20 1 abnormal erythropoiesis 1.0849358072909e-07 6.39764732881428e-06 1.41255338547915 0.504761904761905 20.1 20 1 abnormal embryonic tissue morphology 4.28302466846071e-10 3.94593476399853e-08 1.40874596395495 0.503401360544218 20.1 20 1 abnormal heart morphology 7.04599576540602e-15 1.46057620553729e-12 1.40528467166022 0.502164502164502 20.1 20 1 oxidative stress 1.34901363506292e-06 5.24323658940473e-05 1.39922741014444 0.5 20.1 20 1 hydronephrosis 2.99846196836946e-06 0.000110498876241764 1.39922741014444 0.5 20.1 20 1 abnormal angiogenesis 1.14038381769863e-05 0.000343842999578829 1.39922741014444 0.5 20.1 20 1 abnormal small intestine morphology 0.000169112367957179 0.00308180963584968 1.39922741014444 0.5 20.1 20 1 neurodegeneration 0.000169112367957179 0.00308180963584968 1.39922741014444 0.5 20.1 20 1 axon degeneration 0.000169112367957179 0.00308180963584968 1.39922741014444 0.5 20.1 20 1 disheveled coat 0.000874871477396247 0.0112545867172838 1.39922741014444 0.5 20.1 20 1 skin edema 0.000874871477396247 0.0112545867172838 1.39922741014444 0.5 20.1 20 1 abnormal reproductive system morphology 0.000874871477396247 0.0112545867172838 1.39922741014444 0.5 20.1 20 1 abnormal spleen red pulp morphology 0.00266422184992885 0.0270500075579511 1.39922741014444 0.5 20.1 20 1 abnormal direction of heart looping 0.00266422184992885 0.0270500075579511 1.39922741014444 0.5 20.1 20 1 abnormal heart atrium morphology 0.00353061464916415 0.033843560461641 1.39922741014444 0.5 20.1 20 1 increased fatty acid level 0.00353061464916415 0.033843560461641 1.39922741014444 0.5 20.1 20 1 abnormal leukocyte cell number 0.00830174397856483 0.0630552309822291 1.39922741014444 0.5 20.1 20 1 thick skin 0.00830174397856483 0.0630552309822291 1.39922741014444 0.5 20.1 20 1 decreased bone resorption 0.00830174397856483 0.0630552309822291 1.39922741014444 0.5 20.1 20 1 abnormal extraembryonic endoderm formation 0.0364416261227493 0.184620254542442 1.39922741014444 0.5 20.1 20 1 paternal imprinting 0.0364416261227493 0.184620254542442 1.39922741014444 0.5 20.1 20 1 impaired somite development 0.0364416261227493 0.184620254542442 1.39922741014444 0.5 20.1 20 1 embryonic lethality between somite formation and embryo turning, incomplete penetrance 0.0364416261227493 0.184620254542442 1.39922741014444 0.5 20.1 20 1 decreased body length 4.25668716781283e-17 1.17650103665938e-14 1.39922741014444 0.5 20.1 20 1 abnormal heart development 1.7105304345444e-10 1.70197778237168e-08 1.39922741014444 0.5 20.1 20 1 abnormal cell morphology 5.61063958381068e-08 3.5785810165972e-06 1.39922741014444 0.5 20.1 20 1 abnormal heart left ventricle morphology 1.49086179006652e-05 0.000423830708890338 1.39922741014444 0.5 20.1 20 1 small heart 0.000383401942763901 0.0059236790846286 1.39922741014444 0.5 20.1 20 1 abnormal hair shaft morphology 0.000383401942763901 0.0059236790846286 1.39922741014444 0.5 20.1 20 1 renal interstitial fibrosis 0.000663981669611777 0.00887986238257686 1.39922741014444 0.5 20.1 20 1 abnormal pancreatic beta cell morphology 0.00115381491167747 0.0143505729639885 1.39922741014444 0.5 20.1 20 1 abnormal compact bone morphology 0.00152325333714031 0.0171687470424909 1.39922741014444 0.5 20.1 20 1 heart right ventricle hypertrophy 0.00201325518781145 0.0212202215240719 1.39922741014444 0.5 20.1 20 1 abnormal pharyngeal arch morphology 0.00201325518781145 0.0212202215240719 1.39922741014444 0.5 20.1 20 1 abnormal lysosome morphology 0.00201325518781145 0.0212202215240719 1.39922741014444 0.5 20.1 20 1 narrow eye opening 0.00201325518781145 0.0212202215240719 1.39922741014444 0.5 20.1 20 1 abnormal heart tube morphology 0.00468612384148909 0.04140057596939 1.39922741014444 0.5 20.1 20 1 increased metastatic potential 0.00468612384148909 0.04140057596939 1.39922741014444 0.5 20.1 20 1 decreased body height 0.0110867282315987 0.0792478059658099 1.39922741014444 0.5 20.1 20 1 abnormal body weight 0.0110867282315987 0.0792478059658099 1.39922741014444 0.5 20.1 20 1 decreased metastatic potential 0.0110867282315987 0.0792478059658099 1.39922741014444 0.5 20.1 20 1 curly vibrissae 0.0110867282315987 0.0792478059658099 1.39922741014444 0.5 20.1 20 1 ocular hypertelorism 0.0110867282315987 0.0792478059658099 1.39922741014444 0.5 20.1 20 1 abnormal inner cell mass apoptosis 0.0110867282315987 0.0792478059658099 1.39922741014444 0.5 20.1 20 1 abnormal long bone epiphysis morphology 0.0148463169891352 0.0962672548550516 1.39922741014444 0.5 20.1 20 1 abnormal enterocyte morphology 0.0148463169891352 0.0962672548550516 1.39922741014444 0.5 20.1 20 1 abnormal facial nerve morphology 0.0148463169891352 0.0962672548550516 1.39922741014444 0.5 20.1 20 1 pulmonary vascular congestion 0.0148463169891352 0.0962672548550516 1.39922741014444 0.5 20.1 20 1 rough coat 0.0148463169891352 0.0962672548550516 1.39922741014444 0.5 20.1 20 1 embryonic lethality before implantation, incomplete penetrance 0.0148463169891352 0.0962672548550516 1.39922741014444 0.5 20.1 20 1 abnormal pericardium morphology 0.0199446253724148 0.114313953027377 1.39922741014444 0.5 20.1 20 1 small gonad 0.0199446253724148 0.114313953027377 1.39922741014444 0.5 20.1 20 1 abnormal hair texture 0.0199446253724148 0.114313953027377 1.39922741014444 0.5 20.1 20 1 abnormal lens epithelium morphology 0.0199446253724148 0.114313953027377 1.39922741014444 0.5 20.1 20 1 spleen atrophy 0.0199446253724148 0.114313953027377 1.39922741014444 0.5 20.1 20 1 abnormal physiological neovascularization 0.0199446253724148 0.114313953027377 1.39922741014444 0.5 20.1 20 1 kidney atrophy 0.0199446253724148 0.114313953027377 1.39922741014444 0.5 20.1 20 1 abnormal neuron proliferation 0.0199446253724148 0.114313953027377 1.39922741014444 0.5 20.1 20 1 abnormal phrenic nerve morphology 0.0268966273270053 0.144816797566939 1.39922741014444 0.5 20.1 20 1 eye inflammation 0.0268966273270053 0.144816797566939 1.39922741014444 0.5 20.1 20 1 long tibia 0.0268966273270053 0.144816797566939 1.39922741014444 0.5 20.1 20 1 darkened coat color 0.0268966273270053 0.144816797566939 1.39922741014444 0.5 20.1 20 1 increased effector memory CD8-positive, alpha-beta T cell number 0.0268966273270053 0.144816797566939 1.39922741014444 0.5 20.1 20 1 abnormal aerobic respiration 0.0268966273270053 0.144816797566939 1.39922741014444 0.5 20.1 20 1 abnormal interparietal bone morphology 0.0496620465339192 0.23133771676615 1.39922741014444 0.5 20.1 20 1 absent otoliths 0.0496620465339192 0.23133771676615 1.39922741014444 0.5 20.1 20 1 abnormal ventral body wall morphology 0.0496620465339192 0.23133771676615 1.39922741014444 0.5 20.1 20 1 abnormal hair cuticle 0.0496620465339192 0.23133771676615 1.39922741014444 0.5 20.1 20 1 premature hair loss 0.0496620465339192 0.23133771676615 1.39922741014444 0.5 20.1 20 1 increased circulating growth hormone level 0.0496620465339192 0.23133771676615 1.39922741014444 0.5 20.1 20 1 pulmonary alveolar hemorrhage 0.0496620465339192 0.23133771676615 1.39922741014444 0.5 20.1 20 1 decreased compact bone area 0.0496620465339192 0.23133771676615 1.39922741014444 0.5 20.1 20 1 amyloidosis 0.0681855015198123 0.262590252228645 1.39922741014444 0.5 20.1 20 1 mesocardia 0.0681855015198123 0.262590252228645 1.39922741014444 0.5 20.1 20 1 abnormal thymus involution 0.0681855015198123 0.262590252228645 1.39922741014444 0.5 20.1 20 1 myocarditis 0.0681855015198123 0.262590252228645 1.39922741014444 0.5 20.1 20 1 small intestinal inflammation 0.0681855015198123 0.262590252228645 1.39922741014444 0.5 20.1 20 1 delayed somite formation 0.0681855015198123 0.262590252228645 1.39922741014444 0.5 20.1 20 1 increased hepatocyte proliferation 0.0681855015198123 0.262590252228645 1.39922741014444 0.5 20.1 20 1 decreased renal glomerular filtration rate 0.0681855015198123 0.262590252228645 1.39922741014444 0.5 20.1 20 1 abnormal thymus corticomedullary boundary morphology 0.0681855015198123 0.262590252228645 1.39922741014444 0.5 20.1 20 1 embryonic lethality between implantation and placentation, incomplete penetrance 0.0681855015198123 0.262590252228645 1.39922741014444 0.5 20.1 20 1 enlarged testis 0.0945529916047641 0.33080248469318 1.39922741014444 0.5 20.1 20 1 abnormal epidermis suprabasal layer morphology 0.0945529916047641 0.33080248469318 1.39922741014444 0.5 20.1 20 1 increased atrioventricular cushion size 0.0945529916047641 0.33080248469318 1.39922741014444 0.5 20.1 20 1 increased left ventricle diastolic pressure 0.0945529916047641 0.33080248469318 1.39922741014444 0.5 20.1 20 1 absent pharyngeal arches 0.0945529916047641 0.33080248469318 1.39922741014444 0.5 20.1 20 1 increased heart rate variability 0.0945529916047641 0.33080248469318 1.39922741014444 0.5 20.1 20 1 vascular smooth muscle hyperplasia 0.0945529916047641 0.33080248469318 1.39922741014444 0.5 20.1 20 1 abnormal spinal cord dorsal column morphology 0.0945529916047641 0.33080248469318 1.39922741014444 0.5 20.1 20 1 abnormal cerebellar granule cell migration 0.0945529916047641 0.33080248469318 1.39922741014444 0.5 20.1 20 1 increased circulating fructosamine level 0.0945529916047641 0.33080248469318 1.39922741014444 0.5 20.1 20 1 acanthocytosis 0.0945529916047641 0.33080248469318 1.39922741014444 0.5 20.1 20 1 aorta stenosis 0.0945529916047641 0.33080248469318 1.39922741014444 0.5 20.1 20 1 abnormal left subclavian artery morphology 0.0945529916047641 0.33080248469318 1.39922741014444 0.5 20.1 20 1 thick aortic valve cusps 0.0945529916047641 0.33080248469318 1.39922741014444 0.5 20.1 20 1 abnormal pulmonary interalveolar septum morphology 0.0945529916047641 0.33080248469318 1.39922741014444 0.5 20.1 20 1 increased compact bone area 0.0945529916047641 0.33080248469318 1.39922741014444 0.5 20.1 20 1 abnormal adaptive thermogenesis 0.0945529916047641 0.33080248469318 1.39922741014444 0.5 20.1 20 1 decreased circulating lactate level 0.0945529916047641 0.33080248469318 1.39922741014444 0.5 20.1 20 1 increased fatty acid oxidation 0.0945529916047641 0.33080248469318 1.39922741014444 0.5 20.1 20 1 decreased oocyte number 0.00029166376313087 0.00480472589925854 1.39922741014444 0.5 20.1 20 1 abnormal cell death 0.000504355098153358 0.00725192662807213 1.39922741014444 0.5 20.1 20 1 abnormal allantois morphology 0.000504355098153358 0.00725192662807213 1.39922741014444 0.5 20.1 20 1 abnormal myelin sheath morphology 0.000504355098153358 0.00725192662807213 1.39922741014444 0.5 20.1 20 1 atrial septal defect 0.000504355098153358 0.00725192662807213 1.39922741014444 0.5 20.1 20 1 prenatal lethality, complete penetrance 7.12660093589198e-17 1.77274198280313e-14 1.3891610258988 0.496402877697842 20.1 20 1 decreased circulating serum albumin level 6.87993425147533e-07 2.92544212829827e-05 1.38509379994096 0.494949494949495 20.1 20 1 cardiac fibrosis 4.42344860951822e-06 0.000151781554626897 1.38276591120156 0.494117647058824 20.1 20 1 kyphosis 1.37782876251717e-09 1.07656776226999e-07 1.38057104467585 0.493333333333333 20.1 20 1 corneal opacity 2.87559702974585e-05 0.000718899257436461 1.37951998183255 0.492957746478873 20.1 20 1 decreased spleen weight 3.76163499461781e-05 0.000895413114747541 1.37894875202641 0.492753623188406 20.1 20 1 internal hemorrhage 4.92239850037378e-05 0.00114434264202615 1.37834341894826 0.492537313432836 20.1 20 1 reduced female fertility 8.19306446882956e-14 1.45307358981711e-11 1.37510279962471 0.491379310344828 20.1 20 1 incomplete embryo turning 0.000190029809664632 0.00337642251100551 1.37467956084366 0.491228070175439 20.1 20 1 abnormal dendritic spine morphology 0.000429940895812004 0.00646210258811093 1.37179157857298 0.490196078431373 20.1 20 1 abnormal eye morphology 9.71386442352051e-09 6.90378221528779e-07 1.36902825740751 0.489208633093525 20.1 20 1 impaired macrophage phagocytosis 0.00128908122400485 0.0150191547761689 1.3666872378155 0.488372093023256 20.1 20 1 anemia 2.11467025070344e-12 3.28765140539051e-10 1.36607036251069 0.488151658767773 20.1 20 1 preweaning lethality, complete penetrance 7.50427701333599e-40 9.33344453533664e-37 1.3651921488166 0.487837837837838 20.1 20 1 Leydig cell hyperplasia 0.00169983794997706 0.0189187780786038 1.36509991233604 0.48780487804878 20.1 20 1 palatal shelves fail to meet at midline 0.00169983794997706 0.0189187780786038 1.36509991233604 0.48780487804878 20.1 20 1 abnormal bone structure 2.22734560710974e-11 2.51841918076612e-09 1.36297799537386 0.487046632124352 20.1 20 1 abnormal skeleton morphology 2.28960814403705e-07 1.18654172047753e-05 1.36272582553198 0.48695652173913 20.1 20 1 abnormal vocalization 0.00296489834239532 0.02955985822328 1.36141045311351 0.486486486486487 20.1 20 1 decreased width of hypertrophic chondrocyte zone 0.00296489834239532 0.02955985822328 1.36141045311351 0.486486486486487 20.1 20 1 abnormal hair follicle development 0.00296489834239532 0.02955985822328 1.36141045311351 0.486486486486487 20.1 20 1 skin inflammation 0.00296489834239532 0.02955985822328 1.36141045311351 0.486486486486487 20.1 20 1 increased bone mineral content 5.05478735415499e-07 2.34240301848932e-05 1.36071656399368 0.486238532110092 20.1 20 1 abnormal dermal layer morphology 0.0039226623040463 0.0368123644792571 1.35924948414031 0.485714285714286 20.1 20 1 ovary cysts 0.0039226623040463 0.0368123644792571 1.35924948414031 0.485714285714286 20.1 20 1 abnormal midbrain development 0.0039226623040463 0.0368123644792571 1.35924948414031 0.485714285714286 20.1 20 1 pericardial edema 7.15876623748331e-05 0.00147779510504064 1.35807366278725 0.485294117647059 20.1 20 1 decreased brown adipose tissue amount 0.00519687945218785 0.044347298927332 1.356826579534 0.484848484848485 20.1 20 1 abnormal osteoclast physiology 0.000122612030423939 0.00236432112929882 1.35550155357743 0.484375 20.1 20 1 pericardial effusion 0.000160557551914581 0.00295842155842607 1.35409104207527 0.483870967741935 20.1 20 1 abnormal eyelid morphology 0.00689549868477901 0.0548846887598281 1.35409104207527 0.483870967741935 20.1 20 1 preaxial polydactyly 0.00689549868477901 0.0548846887598281 1.35409104207527 0.483870967741935 20.1 20 1 increased grip strength 5.47552174255548e-06 0.00018282362865244 1.35309903398583 0.483516483516484 20.1 20 1 epidermal hyperplasia 0.000210334242443182 0.00362080573063955 1.35258649647296 0.483333333333333 20.1 20 1 dermatitis 0.000275666008975795 0.00457146131551526 1.35097818910498 0.482758620689655 20.1 20 1 abnormal spinal nerve morphology 0.00916503234964017 0.0683598739722037 1.35097818910498 0.482758620689655 20.1 20 1 abnormal embryonic erythropoiesis 0.00916503234964017 0.0683598739722037 1.35097818910498 0.482758620689655 20.1 20 1 blood in lymph vessels 0.00916503234964017 0.0683598739722037 1.35097818910498 0.482758620689655 20.1 20 1 increased heart weight 2.62143540009587e-08 1.7388854820636e-06 1.34889548891622 0.482014388489209 20.1 20 1 abnormal long bone epiphyseal plate proliferative zone 0.000474206502951547 0.00690777406733644 1.34740417273168 0.481481481481481 20.1 20 1 abnormal atrioventricular cushion morphology 0.0122052982344291 0.0852009214194403 1.34740417273168 0.481481481481481 20.1 20 1 rectal prolapse 0.0122052982344291 0.0852009214194403 1.34740417273168 0.481481481481481 20.1 20 1 abnormal trigeminal nerve morphology 0.0122052982344291 0.0852009214194403 1.34740417273168 0.481481481481481 20.1 20 1 abnormal bone trabecula morphology 0.0122052982344291 0.0852009214194403 1.34740417273168 0.481481481481481 20.1 20 1 decreased heart weight 2.0688198768617e-05 0.000556344804723619 1.34740417273168 0.481481481481481 20.1 20 1 decreased B cell proliferation 2.70052595078834e-05 0.000685465132916939 1.34609219203769 0.481012658227848 20.1 20 1 abnormal snout morphology 0.000622458069168848 0.00836953755166222 1.34541097129273 0.480769230769231 20.1 20 1 abnormal hair growth 0.000622458069168848 0.00836953755166222 1.34541097129273 0.480769230769231 20.1 20 1 abnormal interventricular septum morphology 0.000817542239884067 0.0107033490616401 1.34325831373866 0.48 20.1 20 1 abnormal egg cylinder morphology 0.0162903834013788 0.102718196985881 1.34325831373866 0.48 20.1 20 1 decreased placenta weight 0.0162903834013788 0.102718196985881 1.34325831373866 0.48 20.1 20 1 astrocytosis 6.01515105090083e-05 0.00133536024347117 1.34172491383713 0.479452054794521 20.1 20 1 overriding aortic valve 0.0010744549570844 0.013464517409307 1.34092626805509 0.479166666666667 20.1 20 1 atelectasis 7.85969574631976e-05 0.00158951163975369 1.34010512520876 0.47887323943662 20.1 20 1 abnormal pulmonary artery morphology 0.0217988490897924 0.124083837782285 1.33839143579033 0.478260869565217 20.1 20 1 abnormal cranial nerve morphology 0.0217988490897924 0.124083837782285 1.33839143579033 0.478260869565217 20.1 20 1 blistering 0.0217988490897924 0.124083837782285 1.33839143579033 0.478260869565217 20.1 20 1 abnormal postnatal growth 0.0217988490897924 0.124083837782285 1.33839143579033 0.478260869565217 20.1 20 1 abnormal Wolffian duct morphology 0.0217988490897924 0.124083837782285 1.33839143579033 0.478260869565217 20.1 20 1 decreased effector memory CD8-positive, alpha-beta T cell number 0.0217988490897924 0.124083837782285 1.33839143579033 0.478260869565217 20.1 20 1 omphalocele 0.00185982429540723 0.0201277016762962 1.33562616422878 0.477272727272727 20.1 20 1 decreased sensitivity to induced morbidity/mortality 0.00185982429540723 0.0201277016762962 1.33562616422878 0.477272727272727 20.1 20 1 abnormal cartilage morphology 0.00244980747050508 0.0253384452510661 1.3325975334709 0.476190476190476 20.1 20 1 abnormal salivary gland morphology 0.0292579551020544 0.157190417529936 1.3325975334709 0.476190476190476 20.1 20 1 increased muscle cell glucose uptake 0.0292579551020544 0.157190417529936 1.3325975334709 0.476190476190476 20.1 20 1 decreased susceptibility to hepatic steatosis 0.000229804294204776 0.00391533001256424 1.3325975334709 0.476190476190476 20.1 20 1 liver inflammation 5.13209907568514e-07 2.34240301848932e-05 1.32926603963722 0.475 20.1 20 1 abnormal heart ventricle morphology 5.01544967614064e-05 0.00115490749350227 1.32747215834216 0.474358974358974 20.1 20 1 decreased brain weight 0.000515753210616017 0.00739444444615184 1.3255838622421 0.473684210526316 20.1 20 1 persistence of hyaloid vascular system 0.00426237884712484 0.0386958663584783 1.3255838622421 0.473684210526316 20.1 20 1 incomplete somite formation 0.00426237884712484 0.0386958663584783 1.3255838622421 0.473684210526316 20.1 20 1 decreased neuron apoptosis 0.00426237884712484 0.0386958663584783 1.3255838622421 0.473684210526316 20.1 20 1 decreased total retina thickness 0.00426237884712484 0.0386958663584783 1.3255838622421 0.473684210526316 20.1 20 1 enlarged adrenal glands 0.039409714156828 0.197246808782917 1.3255838622421 0.473684210526316 20.1 20 1 increased malignant tumor incidence 0.039409714156828 0.197246808782917 1.3255838622421 0.473684210526316 20.1 20 1 abnormal digestive system development 0.039409714156828 0.197246808782917 1.3255838622421 0.473684210526316 20.1 20 1 maternal imprinting 0.039409714156828 0.197246808782917 1.3255838622421 0.473684210526316 20.1 20 1 increased left ventricle weight 0.039409714156828 0.197246808782917 1.3255838622421 0.473684210526316 20.1 20 1 abnormal blastocyst morphology 0.039409714156828 0.197246808782917 1.3255838622421 0.473684210526316 20.1 20 1 decreased liver regeneration 0.039409714156828 0.197246808782917 1.3255838622421 0.473684210526316 20.1 20 1 decreased liver glycogen level 0.039409714156828 0.197246808782917 1.3255838622421 0.473684210526316 20.1 20 1 thin interventricular septum 0.039409714156828 0.197246808782917 1.3255838622421 0.473684210526316 20.1 20 1 abnormal intestine morphology 8.53989263908135e-05 0.00169943863517719 1.32359349608258 0.472972972972973 20.1 20 1 abnormal neuromuscular synapse morphology 0.000111471504050905 0.00216629192442676 1.32149255402531 0.472222222222222 20.1 20 1 abnormal epidermis stratum granulosum morphology 0.00563107919751962 0.0466910316794335 1.32149255402531 0.472222222222222 20.1 20 1 abnormal retinal blood vessel morphology 0.00563107919751962 0.0466910316794335 1.32149255402531 0.472222222222222 20.1 20 1 anophthalmia 1.88067278441212e-05 0.000511275797948104 1.32061912867565 0.471910112359551 20.1 20 1 extramedullary hematopoiesis 3.21885108917361e-06 0.000115207080349919 1.32002585862683 0.471698113207547 20.1 20 1 cataract 7.22454457885551e-07 3.04594146439035e-05 1.31828036988815 0.471074380165289 20.1 20 1 abnormal gastrulation 0.00116207676794812 0.0143814226879152 1.31691991543006 0.470588235294118 20.1 20 1 increased kidney weight 0.00116207676794812 0.0143814226879152 1.31691991543006 0.470588235294118 20.1 20 1 lung hemorrhage 0.00744813065419584 0.0579881846707736 1.31691991543006 0.470588235294118 20.1 20 1 abnormal skin physiology 0.00744813065419584 0.0579881846707736 1.31691991543006 0.470588235294118 20.1 20 1 abnormal adipose tissue morphology 0.0533120532582422 0.24512704709774 1.31691991543006 0.470588235294118 20.1 20 1 hydroureter 0.0533120532582422 0.24512704709774 1.31691991543006 0.470588235294118 20.1 20 1 distended urinary bladder 0.0533120532582422 0.24512704709774 1.31691991543006 0.470588235294118 20.1 20 1 abnormal testis development 0.0533120532582422 0.24512704709774 1.31691991543006 0.470588235294118 20.1 20 1 abnormal ectoplacental cone morphology 0.0533120532582422 0.24512704709774 1.31691991543006 0.470588235294118 20.1 20 1 coloboma 0.0533120532582422 0.24512704709774 1.31691991543006 0.470588235294118 20.1 20 1 increased trabecular bone mass 0.0533120532582422 0.24512704709774 1.31691991543006 0.470588235294118 20.1 20 1 decreased body fat mass 0.0533120532582422 0.24512704709774 1.31691991543006 0.470588235294118 20.1 20 1 abnormal lung morphology 9.38272234188902e-07 3.79504419925999e-05 1.31691991543006 0.470588235294118 20.1 20 1 preweaning lethality, incomplete penetrance 1.95618022799324e-19 6.08249789641649e-17 1.3137000623361 0.469437652811736 20.1 20 1 increased T cell derived lymphoma incidence 0.00152501999089064 0.0171687470424909 1.31356042584988 0.469387755102041 20.1 20 1 decreased circulating LDL cholesterol level 0.000324385703423163 0.0052058673371943 1.31177569701041 0.46875 20.1 20 1 abnormal somite development 7.05478724371285e-05 0.00146851742834609 1.31066871329986 0.468354430379747 20.1 20 1 prenatal lethality 0.000423962762814449 0.00639155983333904 1.30895467400609 0.467741935483871 20.1 20 1 abnormal hair cycle 0.0130840772942724 0.0879638980256824 1.30594558280148 0.466666666666667 20.1 20 1 abnormal spleen marginal zone morphology 0.0130840772942724 0.0879638980256824 1.30594558280148 0.466666666666667 20.1 20 1 abnormal microglial cell physiology 0.0130840772942724 0.0879638980256824 1.30594558280148 0.466666666666667 20.1 20 1 abnormal fat pad morphology 0.0130840772942724 0.0879638980256824 1.30594558280148 0.466666666666667 20.1 20 1 abnormal fontanelle morphology 0.0724987613045108 0.271188975556347 1.30594558280148 0.466666666666667 20.1 20 1 decreased hepatocyte number 0.0724987613045108 0.271188975556347 1.30594558280148 0.466666666666667 20.1 20 1 abnormal enteric neuron morphology 0.0724987613045108 0.271188975556347 1.30594558280148 0.466666666666667 20.1 20 1 abnormal epidermis stratum spinosum morphology 0.0724987613045108 0.271188975556347 1.30594558280148 0.466666666666667 20.1 20 1 absent egg cylinders 0.0724987613045108 0.271188975556347 1.30594558280148 0.466666666666667 20.1 20 1 abnormal respiratory system morphology 0.0724987613045108 0.271188975556347 1.30594558280148 0.466666666666667 20.1 20 1 abnormal glial cell morphology 0.0724987613045108 0.271188975556347 1.30594558280148 0.466666666666667 20.1 20 1 abnormal trophectoderm morphology 0.0724987613045108 0.271188975556347 1.30594558280148 0.466666666666667 20.1 20 1 abnormal secondary palate development 0.0724987613045108 0.271188975556347 1.30594558280148 0.466666666666667 20.1 20 1 abnormal aorta wall morphology 0.0724987613045108 0.271188975556347 1.30594558280148 0.466666666666667 20.1 20 1 liver vascular congestion 0.0724987613045108 0.271188975556347 1.30594558280148 0.466666666666667 20.1 20 1 abnormal branching involved in lung morphogenesis 0.0724987613045108 0.271188975556347 1.30594558280148 0.466666666666667 20.1 20 1 postnatal lethality, incomplete penetrance 8.60460273330474e-26 5.35098732477388e-23 1.30561712566295 0.466549295774648 20.1 20 1 abnormal seminiferous tubule morphology 1.12060001082633e-07 6.48254076030351e-06 1.30338991629893 0.465753424657534 20.1 20 1 abnormal pulmonary alveolus morphology 9.87235134498646e-06 0.000307977170393236 1.30225125300572 0.465346534653465 20.1 20 1 increased oxygen consumption 4.45647845833974e-05 0.00104089109531644 1.30160689315762 0.465116279069767 20.1 20 1 abnormal left-right axis patterning 0.00345913464137484 0.0332866437927269 1.30160689315762 0.465116279069767 20.1 20 1 decreased liver weight 0.000203670235237262 0.00354286510596286 1.30069026858497 0.464788732394366 20.1 20 1 increased mean corpuscular hemoglobin 1.28243512720677e-05 0.000377521583304951 1.30029213872009 0.464646464646465 20.1 20 1 reddish skin 0.0173831130016068 0.109469604029106 1.29928259513412 0.464285714285714 20.1 20 1 abnormal myocardial fiber morphology 1.66594191828152e-05 0.000470912559286963 1.29825223621649 0.463917525773196 20.1 20 1 thymus hypoplasia 3.15768621251511e-07 1.57094889072627e-05 1.29783411955426 0.463768115942029 20.1 20 1 respiratory failure 9.25143920725141e-08 5.75323875700947e-06 1.29729693655776 0.463576158940397 20.1 20 1 thick ventricular wall 0.00455118638624842 0.0407449668051703 1.29684491671924 0.463414634146341 20.1 20 1 increased blood urea nitrogen level 2.00771282815668e-07 1.08569253479125e-05 1.29307912385762 0.462068965517241 20.1 20 1 abnormal ureter morphology 0.0231377886209337 0.131105351240484 1.29159453244102 0.461538461538462 20.1 20 1 abnormal Mullerian duct morphology 0.0231377886209337 0.131105351240484 1.29159453244102 0.461538461538462 20.1 20 1 abnormal nerve conduction 0.0231377886209337 0.131105351240484 1.29159453244102 0.461538461538462 20.1 20 1 absent common myeloid progenitor cells 0.0992430307913507 0.339811425884232 1.29159453244102 0.461538461538462 20.1 20 1 absent trabeculae carneae 0.0992430307913507 0.339811425884232 1.29159453244102 0.461538461538462 20.1 20 1 abnormal renal/urinary system morphology 0.0992430307913507 0.339811425884232 1.29159453244102 0.461538461538462 20.1 20 1 increased pituitary adenoma incidence 0.0992430307913507 0.339811425884232 1.29159453244102 0.461538461538462 20.1 20 1 abnormal pulmonary alveolus epithelial cell morphology 0.0992430307913507 0.339811425884232 1.29159453244102 0.461538461538462 20.1 20 1 abnormal tail bud morphology 0.0992430307913507 0.339811425884232 1.29159453244102 0.461538461538462 20.1 20 1 abnormal bile duct development 0.0992430307913507 0.339811425884232 1.29159453244102 0.461538461538462 20.1 20 1 abnormal coping response 0.0992430307913507 0.339811425884232 1.29159453244102 0.461538461538462 20.1 20 1 anal atresia 0.0992430307913507 0.339811425884232 1.29159453244102 0.461538461538462 20.1 20 1 axonal dystrophy 0.0992430307913507 0.339811425884232 1.29159453244102 0.461538461538462 20.1 20 1 small otic vesicle 0.0992430307913507 0.339811425884232 1.29159453244102 0.461538461538462 20.1 20 1 small interparietal bone 0.0992430307913507 0.339811425884232 1.29159453244102 0.461538461538462 20.1 20 1 increased cochlear inner hair cell number 0.0992430307913507 0.339811425884232 1.29159453244102 0.461538461538462 20.1 20 1 abnormal vertebral arch development 0.0992430307913507 0.339811425884232 1.29159453244102 0.461538461538462 20.1 20 1 increased circulating thyroxine level 0.0992430307913507 0.339811425884232 1.29159453244102 0.461538461538462 20.1 20 1 orthokeratosis 0.0992430307913507 0.339811425884232 1.29159453244102 0.461538461538462 20.1 20 1 decreased cardiac stroke volume 0.0992430307913507 0.339811425884232 1.29159453244102 0.461538461538462 20.1 20 1 increased insulin sensitivity 2.59902882147858e-07 1.31940493743428e-05 1.29159453244102 0.461538461538462 20.1 20 1 increased vascular permeability 0.0059926555233968 0.0490352980738472 1.29159453244102 0.461538461538462 20.1 20 1 abnormal circulating hormone level 0.0059926555233968 0.0490352980738472 1.29159453244102 0.461538461538462 20.1 20 1 increased circulating aspartate transaminase level 0.000589568515452107 0.00816595386381638 1.28817761568853 0.46031746031746 20.1 20 1 perinatal lethality, complete penetrance 4.71125369756354e-10 4.26154311734156e-08 1.28755198304371 0.460093896713615 20.1 20 1 abnormal hepatocyte morphology 6.64627929701775e-06 0.000217534470412259 1.28577653905165 0.459459459459459 20.1 20 1 increased erythroid progenitor cell number 0.00789733292437519 0.0611540288775586 1.28577653905165 0.459459459459459 20.1 20 1 abnormal calcium ion homeostasis 0.00789733292437519 0.0611540288775586 1.28577653905165 0.459459459459459 20.1 20 1 increased trabecular bone volume 0.00789733292437519 0.0611540288775586 1.28577653905165 0.459459459459459 20.1 20 1 abnormal intestinal epithelium morphology 0.00278770460185045 0.0280745554538583 1.28262512596574 0.458333333333333 20.1 20 1 abnormal digestive system morphology 0.0308629513544177 0.164041862166911 1.28262512596574 0.458333333333333 20.1 20 1 increased stereotypic behavior 0.0308629513544177 0.164041862166911 1.28262512596574 0.458333333333333 20.1 20 1 blindness 0.0308629513544177 0.164041862166911 1.28262512596574 0.458333333333333 20.1 20 1 increased hemangiosarcoma incidence 0.0308629513544177 0.164041862166911 1.28262512596574 0.458333333333333 20.1 20 1 hydrops fetalis 0.000281684546241104 0.00465574955996509 1.28262512596574 0.458333333333333 20.1 20 1 microphthalmia 1.74818524720926e-07 9.77215910659108e-06 1.28033880666812 0.457516339869281 20.1 20 1 spleen hypoplasia 1.44650021183067e-05 0.000413582675509057 1.27929363213206 0.457142857142857 20.1 20 1 domed cranium 0.000366688584103981 0.00571873262043043 1.27929363213206 0.457142857142857 20.1 20 1 increased circulating serum albumin level 0.0104169461069534 0.0758774624920835 1.27929363213206 0.457142857142857 20.1 20 1 abnormal embryonic epiblast morphology 0.0104169461069534 0.0758774624920835 1.27929363213206 0.457142857142857 20.1 20 1 decreased bone volume 0.0104169461069534 0.0758774624920835 1.27929363213206 0.457142857142857 20.1 20 1 increased neuron apoptosis 0.000135191625178332 0.00256709288268017 1.27830652284801 0.45679012345679 20.1 20 1 abnormal spermatogenesis 1.23628618219147e-08 8.54239410611464e-07 1.27755546143623 0.456521739130435 20.1 20 1 decreased body weight 2.9957804695999e-50 7.45200391812975e-47 1.27716233720777 0.456381260096931 20.1 20 1 abnormal visceral yolk sac morphology 0.00017564473689537 0.00316606002193646 1.27524523456202 0.455696202531646 20.1 20 1 decreased circulating glucose level 3.49270031989536e-12 4.69626597067011e-10 1.27384860995229 0.455197132616487 20.1 20 1 abnormal platelet physiology 0.00171191520644704 0.0189522576091169 1.27202491831313 0.454545454545455 20.1 20 1 abnormal bone mineralization 4.42378400420102e-06 0.000151781554626897 1.27202491831313 0.454545454545455 20.1 20 1 abnormal astrocyte morphology 0.0047918932630145 0.04140057596939 1.27202491831313 0.454545454545455 20.1 20 1 abnormal tooth development 0.0137542094754329 0.0916026668544562 1.27202491831313 0.454545454545455 20.1 20 1 abnormal ovarian folliculogenesis 0.0137542094754329 0.0916026668544562 1.27202491831313 0.454545454545455 20.1 20 1 abnormal abdominal fat pad morphology 0.0412676535294868 0.204692498812759 1.27202491831313 0.454545454545455 20.1 20 1 abnormal tail movements 0.0412676535294868 0.204692498812759 1.27202491831313 0.454545454545455 20.1 20 1 aphakia 0.0412676535294868 0.204692498812759 1.27202491831313 0.454545454545455 20.1 20 1 abnormal lysosome physiology 0.0412676535294868 0.204692498812759 1.27202491831313 0.454545454545455 20.1 20 1 parakeratosis 0.0412676535294868 0.204692498812759 1.27202491831313 0.454545454545455 20.1 20 1 premature suture closure 0.137015889605133 0.416150214154784 1.27202491831313 0.454545454545455 20.1 20 1 abnormal awl hair morphology 0.137015889605133 0.416150214154784 1.27202491831313 0.454545454545455 20.1 20 1 abnormal stomach epithelium morphology 0.137015889605133 0.416150214154784 1.27202491831313 0.454545454545455 20.1 20 1 abnormal enteric ganglia morphology 0.137015889605133 0.416150214154784 1.27202491831313 0.454545454545455 20.1 20 1 social withdrawal 0.137015889605133 0.416150214154784 1.27202491831313 0.454545454545455 20.1 20 1 abnormal hemoglobin 0.137015889605133 0.416150214154784 1.27202491831313 0.454545454545455 20.1 20 1 abnormal bronchiole morphology 0.137015889605133 0.416150214154784 1.27202491831313 0.454545454545455 20.1 20 1 retinal detachment 0.137015889605133 0.416150214154784 1.27202491831313 0.454545454545455 20.1 20 1 patent ductus arteriosus 0.137015889605133 0.416150214154784 1.27202491831313 0.454545454545455 20.1 20 1 impaired luteinization 0.137015889605133 0.416150214154784 1.27202491831313 0.454545454545455 20.1 20 1 abnormal coronal suture morphology 0.137015889605133 0.416150214154784 1.27202491831313 0.454545454545455 20.1 20 1 abnormal spinal cord ventral horn morphology 0.137015889605133 0.416150214154784 1.27202491831313 0.454545454545455 20.1 20 1 increased circulating triiodothyronine level 0.137015889605133 0.416150214154784 1.27202491831313 0.454545454545455 20.1 20 1 palatal shelf hypoplasia 0.137015889605133 0.416150214154784 1.27202491831313 0.454545454545455 20.1 20 1 common atrioventricular valve 0.137015889605133 0.416150214154784 1.27202491831313 0.454545454545455 20.1 20 1 postnatal growth retardation 9.07943471317395e-25 4.85925570766976e-22 1.27119352947763 0.454248366013072 20.1 20 1 premature death 2.40182715911177e-34 1.99151501943018e-31 1.27084301362712 0.454123112659698 20.1 20 1 increased circulating creatinine level 0.00010957169829676 0.00213772234912306 1.26906672082868 0.453488372093023 20.1 20 1 abnormal neurocranium morphology 0.000296486882475817 0.00483613849284324 1.26863285186429 0.453333333333333 20.1 20 1 cyanosis 1.06404829436783e-08 7.45583135842247e-07 1.2680498404434 0.453125 20.1 20 1 alopecia 5.27998690904965e-05 0.00119944908093708 1.26666902392023 0.452631578947368 20.1 20 1 increased inflammatory response 5.27998690904965e-05 0.00119944908093708 1.26666902392023 0.452631578947368 20.1 20 1 abnormal muscle morphology 0.00628710809925384 0.0509419589475372 1.26596765679735 0.452380952380952 20.1 20 1 decreased hematocrit 6.61889107713257e-07 2.86338983554213e-05 1.26505491876073 0.452054794520548 20.1 20 1 decreased bone mineral content 3.30022201193036e-09 2.52593915528516e-07 1.26468631301517 0.451923076923077 20.1 20 1 hypoglycemia 6.83887700377962e-05 0.00143109391032846 1.26381830593691 0.451612903225806 20.1 20 1 lethargy 6.83887700377962e-05 0.00143109391032846 1.26381830593691 0.451612903225806 20.1 20 1 abnormal gluconeogenesis 0.00292086541863936 0.0293561726418804 1.26204825228714 0.450980392156863 20.1 20 1 increased circulating alkaline phosphatase level 2.03734149726736e-07 1.08986816654894e-05 1.26103211037709 0.450617283950617 20.1 20 1 cleft palate 2.91896335743669e-06 0.000108371960471997 1.26037278165682 0.450381679389313 20.1 20 1 abnormal basioccipital bone morphology 0.0553356958895296 0.248597250361495 1.25930466913 0.45 20.1 20 1 abnormal dopamine level 0.0553356958895296 0.248597250361495 1.25930466913 0.45 20.1 20 1 decreased myocardial infarction size 0.0553356958895296 0.248597250361495 1.25930466913 0.45 20.1 20 1 absent placental labyrinth 0.0553356958895296 0.248597250361495 1.25930466913 0.45 20.1 20 1 abnormal optic stalk morphology 0.0553356958895296 0.248597250361495 1.25930466913 0.45 20.1 20 1 decreased circulating VLDL cholesterol level 0.0553356958895296 0.248597250361495 1.25930466913 0.45 20.1 20 1 abnormal response to tactile stimuli 0.0553356958895296 0.248597250361495 1.25930466913 0.45 20.1 20 1 abnormal induced retinal neovascularization 0.0553356958895296 0.248597250361495 1.25930466913 0.45 20.1 20 1 abnormal heart electrocardiography waveform feature 0.0553356958895296 0.248597250361495 1.25930466913 0.45 20.1 20 1 abnormal liver physiology 4.27076500332763e-05 0.00100696947353341 1.25930466913 0.45 20.1 20 1 abnormal renal glomerulus morphology 2.06513293448906e-05 0.000556344804723619 1.2580209742583 0.44954128440367 20.1 20 1 decreased rib number 0.000114696652830986 0.00222029512775936 1.25773250350062 0.449438202247191 20.1 20 1 cardiac hypertrophy 5.52392172550323e-05 0.00124350726626147 1.25644910298684 0.448979591836735 20.1 20 1 increased sarcoma incidence 0.00381655872929916 0.0363047412586296 1.25644910298684 0.448979591836735 20.1 20 1 abnormal respiratory system physiology 0.00381655872929916 0.0363047412586296 1.25644910298684 0.448979591836735 20.1 20 1 increased T cell proliferation 2.66845854691701e-05 0.000680799039533956 1.25538160162492 0.448598130841121 20.1 20 1 thrombocytosis 0.00178727729067517 0.0196284868015651 1.25447974702605 0.448275862068966 20.1 20 1 increased double-positive T cell number 0.0240603035313297 0.134856373370864 1.25447974702605 0.448275862068966 20.1 20 1 retinal degeneration 7.14373663420302e-05 0.00147779510504064 1.25347455492106 0.447916666666667 20.1 20 1 abnormal cranium morphology 3.04916472780992e-06 0.000111541136182753 1.25303947177114 0.447761194029851 20.1 20 1 maternal effect 0.000844628909793804 0.0110289470504572 1.25303947177114 0.447761194029851 20.1 20 1 abnormal coat/hair pigmentation 2.15297007646959e-05 0.000571132342438872 1.24931018762896 0.446428571428571 20.1 20 1 abnormal behavior 3.31919662005029e-11 3.58978330103265e-09 1.24823164645979 0.446043165467626 20.1 20 1 small testis 4.26402287313104e-11 4.41948204038061e-09 1.24713747425918 0.445652173913043 20.1 20 1 abnormal maxilla morphology 0.00303181555734498 0.0301454210306722 1.24375769790617 0.444444444444444 20.1 20 1 irregular heartbeat 0.00652060235515586 0.0526623323326305 1.24375769790617 0.444444444444444 20.1 20 1 cardiomyopathy 0.00652060235515586 0.0526623323326305 1.24375769790617 0.444444444444444 20.1 20 1 abnormal heart valve morphology 0.0318837809301374 0.168389612197224 1.24375769790617 0.444444444444444 20.1 20 1 abnormal fetal cardiomyocyte proliferation 0.0318837809301374 0.168389612197224 1.24375769790617 0.444444444444444 20.1 20 1 enlarged spleen 2.17551491640313e-11 2.51702016490827e-09 1.24375769790617 0.444444444444444 20.1 20 1 abnormal neural tube morphology 4.72948414064948e-07 2.23308983625305e-05 1.24375769790617 0.444444444444444 20.1 20 1 increased exploration in new environment 0.000322107876681643 0.00518604105660575 1.24375769790617 0.444444444444444 20.1 20 1 abnormal megakaryocyte differentiation 0.0744443940032317 0.274341377900798 1.24375769790617 0.444444444444444 20.1 20 1 abnormal mitral valve morphology 0.0744443940032317 0.274341377900798 1.24375769790617 0.444444444444444 20.1 20 1 absent spleen 0.0744443940032317 0.274341377900798 1.24375769790617 0.444444444444444 20.1 20 1 abnormal thymus cortex morphology 0.0744443940032317 0.274341377900798 1.24375769790617 0.444444444444444 20.1 20 1 abnormal thymus medulla morphology 0.0744443940032317 0.274341377900798 1.24375769790617 0.444444444444444 20.1 20 1 decreased activity of thyroid 0.0744443940032317 0.274341377900798 1.24375769790617 0.444444444444444 20.1 20 1 absent ureter 0.0744443940032317 0.274341377900798 1.24375769790617 0.444444444444444 20.1 20 1 decreased lactate dehydrogenase level 0.0744443940032317 0.274341377900798 1.24375769790617 0.444444444444444 20.1 20 1 abnormal pregnancy 0.0744443940032317 0.274341377900798 1.24375769790617 0.444444444444444 20.1 20 1 abnormal sperm axoneme morphology 0.0744443940032317 0.274341377900798 1.24375769790617 0.444444444444444 20.1 20 1 decreased tumor latency 0.0744443940032317 0.274341377900798 1.24375769790617 0.444444444444444 20.1 20 1 atrioventricular block 0.0744443940032317 0.274341377900798 1.24375769790617 0.444444444444444 20.1 20 1 abnormal metanephric mesenchyme morphology 0.0744443940032317 0.274341377900798 1.24375769790617 0.444444444444444 20.1 20 1 thick epidermis 0.000875482424037957 0.0112545867172838 1.23931570612793 0.442857142857143 20.1 20 1 increased osteoclast cell number 0.0018512040565738 0.0201277016762962 1.2386603302918 0.442622950819672 20.1 20 1 decreased kidney weight 0.00394893237592877 0.0368123644792571 1.23777809358931 0.442307692307692 20.1 20 1 abnormal organ of Corti morphology 0.00852592042007467 0.0645608129221788 1.23652654849974 0.441860465116279 20.1 20 1 kinked tail 7.68509375708263e-05 0.00156054454863208 1.23461242071568 0.441176470588235 20.1 20 1 impaired balance 7.68509375708263e-05 0.00156054454863208 1.23461242071568 0.441176470588235 20.1 20 1 decreased body size 4.37540064782839e-28 3.10965974613518e-25 1.23440613626778 0.441102756892231 20.1 20 1 reduced male fertility 5.61882481218903e-09 4.1721870806926e-07 1.23279948030347 0.440528634361233 20.1 20 1 arrest of spermatogenesis 0.000332924185080992 0.00526056092509962 1.23265271846058 0.44047619047619 20.1 20 1 spleen hyperplasia 0.000697509926946868 0.00923199103338163 1.23132012092711 0.44 20.1 20 1 decreased double-positive T cell number 9.90505397562811e-05 0.00194773294580039 1.23132012092711 0.44 20.1 20 1 short stride length 0.0051435299840681 0.0439674599153587 1.23132012092711 0.44 20.1 20 1 increased circulating chloride level 0.0051435299840681 0.0439674599153587 1.23132012092711 0.44 20.1 20 1 mandible hypoplasia 0.0423128261746625 0.208617420369405 1.23132012092711 0.44 20.1 20 1 decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 0.0423128261746625 0.208617420369405 1.23132012092711 0.44 20.1 20 1 enlarged heart 4.52686888765297e-09 3.41229889637477e-07 1.23035513650632 0.439655172413793 20.1 20 1 limb grasping 1.99450571266373e-07 1.08569253479125e-05 1.23009003089621 0.43956043956044 20.1 20 1 abnormal enzyme/coenzyme activity 1.33401989722576e-06 5.24323658940473e-05 1.22989415668747 0.439490445859873 20.1 20 1 liver fibrosis 0.0111503376710865 0.0794741116241483 1.22858992110244 0.439024390243902 20.1 20 1 increased tumor growth/size 0.0111503376710865 0.0794741116241483 1.22858992110244 0.439024390243902 20.1 20 1 polydactyly 0.000127627355903581 0.00245152932671937 1.22789344155533 0.438775510204082 20.1 20 1 increased macrophage cell number 0.00312208649954234 0.0308182149508395 1.22739246503898 0.43859649122807 20.1 20 1 decreased grip strength 1.51556313598026e-08 1.03286665773997e-06 1.22671992122252 0.438356164383562 20.1 20 1 kidney cortex cysts 0.0246485847407863 0.136860166389969 1.22432398387639 0.4375 20.1 20 1 abnormal lymphatic vessel morphology 0.0246485847407863 0.136860166389969 1.22432398387639 0.4375 20.1 20 1 pancreatic islet hyperplasia 0.0246485847407863 0.136860166389969 1.22432398387639 0.4375 20.1 20 1 abnormal auditory brainstem response waveform shape 0.0246485847407863 0.136860166389969 1.22432398387639 0.4375 20.1 20 1 abnormal mouth morphology 0.100543199779214 0.339811425884232 1.22432398387639 0.4375 20.1 20 1 disorganized retinal layers 0.100543199779214 0.339811425884232 1.22432398387639 0.4375 20.1 20 1 abnormal intestinal absorption 0.100543199779214 0.339811425884232 1.22432398387639 0.4375 20.1 20 1 impaired muscle relaxation 0.100543199779214 0.339811425884232 1.22432398387639 0.4375 20.1 20 1 increased pancreatic beta cell number 0.100543199779214 0.339811425884232 1.22432398387639 0.4375 20.1 20 1 small pancreas 0.100543199779214 0.339811425884232 1.22432398387639 0.4375 20.1 20 1 bowed tibia 0.100543199779214 0.339811425884232 1.22432398387639 0.4375 20.1 20 1 increased cochlear outer hair cell number 0.100543199779214 0.339811425884232 1.22432398387639 0.4375 20.1 20 1 increased thymus weight 0.100543199779214 0.339811425884232 1.22432398387639 0.4375 20.1 20 1 dystonia 0.100543199779214 0.339811425884232 1.22432398387639 0.4375 20.1 20 1 loose skin 0.100543199779214 0.339811425884232 1.22432398387639 0.4375 20.1 20 1 decreased liver cholesterol level 0.100543199779214 0.339811425884232 1.22432398387639 0.4375 20.1 20 1 abnormal thoracic cage shape 0.100543199779214 0.339811425884232 1.22432398387639 0.4375 20.1 20 1 decreased midbrain size 0.100543199779214 0.339811425884232 1.22432398387639 0.4375 20.1 20 1 decreased fibroblast apoptosis 0.100543199779214 0.339811425884232 1.22432398387639 0.4375 20.1 20 1 vertebral transformation 0.00669942877934237 0.0539314857236704 1.22432398387639 0.4375 20.1 20 1 abnormal ovary morphology 0.0011661346999382 0.0143958315935299 1.2218605553374 0.436619718309859 20.1 20 1 decreased circulating calcium level 0.00405367389352406 0.0374851814503386 1.2211439215806 0.436363636363636 20.1 20 1 cleft secondary palate 0.000211700820778615 0.00363176408059866 1.22060263438132 0.436170212765957 20.1 20 1 decreased bone mineral density 7.47982949903424e-10 6.30714436571107e-08 1.22037879381019 0.43609022556391 20.1 20 1 abnormal cardiovascular system physiology 1.18909734971031e-05 0.000354237084719088 1.22037879381019 0.43609022556391 20.1 20 1 impaired macrophage chemotaxis 0.0145855242346919 0.0956034032511099 1.21983928063874 0.435897435897436 20.1 20 1 decreased B-1 B cell number 0.0145855242346919 0.0956034032511099 1.21983928063874 0.435897435897436 20.1 20 1 short snout 8.13344987327451e-05 0.00163821510605428 1.21784607919979 0.435185185185185 20.1 20 1 dilated heart 0.0562436569446365 0.248597250361495 1.21671948708212 0.434782608695652 20.1 20 1 abnormal chondrocyte physiology 0.0562436569446365 0.248597250361495 1.21671948708212 0.434782608695652 20.1 20 1 abnormal basicranium morphology 0.0562436569446365 0.248597250361495 1.21671948708212 0.434782608695652 20.1 20 1 increased circulating bilirubin level 0.00526227132169731 0.0448284243586372 1.21442378993668 0.433962264150943 20.1 20 1 abnormal embryo size 6.48584356156824e-05 0.00140291616168704 1.21348925835536 0.433628318584071 20.1 20 1 male infertility 7.61455729185331e-17 1.80392488223668e-14 1.21284920640751 0.433399602385686 20.1 20 1 decreased insulin secretion 0.000350680883720115 0.00548628112109299 1.21266375545852 0.433333333333333 20.1 20 1 abnormal kidney development 0.00319330585492106 0.0310287043520162 1.21266375545852 0.433333333333333 20.1 20 1 intracranial hemorrhage 0.00319330585492106 0.0310287043520162 1.21266375545852 0.433333333333333 20.1 20 1 decreased compact bone thickness 0.00194732625552893 0.0208791985371906 1.21127148937877 0.432835820895522 20.1 20 1 abnormal pancreatic beta cell physiology 0.0190824447469767 0.110471732999841 1.21014262498979 0.432432432432432 20.1 20 1 abnormal chromosome morphology 0.0190824447469767 0.110471732999841 1.21014262498979 0.432432432432432 20.1 20 1 abnormal humerus morphology 0.0190824447469767 0.110471732999841 1.21014262498979 0.432432432432432 20.1 20 1 teratozoospermia 0.000451085772010539 0.00665920390430989 1.20842367239747 0.431818181818182 20.1 20 1 abnormal myelopoiesis 0.0113637810594406 0.0805339184768045 1.20842367239747 0.431818181818182 20.1 20 1 muscular atrophy 0.0113637810594406 0.0805339184768045 1.20842367239747 0.431818181818182 20.1 20 1 lethality, incomplete penetrance 0.0113637810594406 0.0805339184768045 1.20842367239747 0.431818181818182 20.1 20 1 distended abdomen 0.00682968930956581 0.0548027488953063 1.20717658914422 0.431372549019608 20.1 20 1 increased lung adenocarcinoma incidence 0.00682968930956581 0.0548027488953063 1.20717658914422 0.431372549019608 20.1 20 1 spina bifida 0.0147977598499612 0.0962672548550516 1.19933778012381 0.428571428571429 20.1 20 1 abnormal eye pigmentation 0.0748940014801363 0.275386295169016 1.19933778012381 0.428571428571429 20.1 20 1 abnormal hematopoietic system physiology 0.0748940014801363 0.275386295169016 1.19933778012381 0.428571428571429 20.1 20 1 increased bone ossification 0.0748940014801363 0.275386295169016 1.19933778012381 0.428571428571429 20.1 20 1 weight loss 1.54119543272646e-06 5.94375757970086e-05 1.19933778012381 0.428571428571429 20.1 20 1 abnormal brain morphology 3.94661883275351e-06 0.000137303697153488 1.19933778012381 0.428571428571429 20.1 20 1 abnormal eye development 0.00534810937316952 0.0454817848402023 1.19933778012381 0.428571428571429 20.1 20 1 abnormal artery morphology 0.0249695027416596 0.137872670521372 1.19933778012381 0.428571428571429 20.1 20 1 holoprosencephaly 0.0249695027416596 0.137872670521372 1.19933778012381 0.428571428571429 20.1 20 1 decreased glycogen level 0.0249695027416596 0.137872670521372 1.19933778012381 0.428571428571429 20.1 20 1 increased red blood cell distribution width 0.0249695027416596 0.137872670521372 1.19933778012381 0.428571428571429 20.1 20 1 impaired adaptive thermogenesis 0.0249695027416596 0.137872670521372 1.19933778012381 0.428571428571429 20.1 20 1 abnormal somite shape 0.0427592818765354 0.208981314474347 1.19933778012381 0.428571428571429 20.1 20 1 absent corpus callosum 0.0427592818765354 0.208981314474347 1.19933778012381 0.428571428571429 20.1 20 1 abnormal blood flow velocity 0.136428768984424 0.416150214154784 1.19933778012381 0.428571428571429 20.1 20 1 abnormal zigzag hair morphology 0.136428768984424 0.416150214154784 1.19933778012381 0.428571428571429 20.1 20 1 megacephaly 0.136428768984424 0.416150214154784 1.19933778012381 0.428571428571429 20.1 20 1 extended life span 0.136428768984424 0.416150214154784 1.19933778012381 0.428571428571429 20.1 20 1 decreased vascular permeability 0.136428768984424 0.416150214154784 1.19933778012381 0.428571428571429 20.1 20 1 failure of zygotic cell division 0.136428768984424 0.416150214154784 1.19933778012381 0.428571428571429 20.1 20 1 abnormal vascular endothelial cell migration 0.136428768984424 0.416150214154784 1.19933778012381 0.428571428571429 20.1 20 1 abnormal imprinting 0.136428768984424 0.416150214154784 1.19933778012381 0.428571428571429 20.1 20 1 abnormal sagittal suture morphology 0.136428768984424 0.416150214154784 1.19933778012381 0.428571428571429 20.1 20 1 skeletal muscle necrosis 0.136428768984424 0.416150214154784 1.19933778012381 0.428571428571429 20.1 20 1 abnormal maternal decidual layer morphology 0.136428768984424 0.416150214154784 1.19933778012381 0.428571428571429 20.1 20 1 decreased CNS synapse formation 0.136428768984424 0.416150214154784 1.19933778012381 0.428571428571429 20.1 20 1 abnormal viscerocranium morphology 0.136428768984424 0.416150214154784 1.19933778012381 0.428571428571429 20.1 20 1 abnormal renal tubule epithelial cell primary cilium morphology 0.136428768984424 0.416150214154784 1.19933778012381 0.428571428571429 20.1 20 1 decreased response to antigen 0.136428768984424 0.416150214154784 1.19933778012381 0.428571428571429 20.1 20 1 postnatal lethality 3.14607134104727e-06 0.000113555030280951 1.19692947132838 0.427710843373494 20.1 20 1 thrombocytopenia 1.2940309166083e-05 0.000378694341772135 1.19658068177869 0.427586206896552 20.1 20 1 increased B cell number 8.63445195192884e-05 0.00171141029724486 1.19592086337132 0.427350427350427 20.1 20 1 hypoactivity 3.38889478381249e-12 4.6857675216414e-10 1.1950960903621 0.427055702917772 20.1 20 1 abnormal muscle physiology 0.000589285612951459 0.00816595386381638 1.19484587832559 0.426966292134831 20.1 20 1 neonatal lethality, incomplete penetrance 7.30753831570006e-09 5.26884103197215e-07 1.19472494250795 0.426923076923077 20.1 20 1 sparse hair 0.000957534546575842 0.0122776659000382 1.19446242329403 0.426829268292683 20.1 20 1 delayed bone ossification 0.00156041210154634 0.0174843473089933 1.19400738998992 0.426666666666667 20.1 20 1 decreased circulating alanine transaminase level 0.0025516905809169 0.0261745580207455 1.19345867335849 0.426470588235294 20.1 20 1 abnormal chondrocyte morphology 0.00691712559847481 0.0548846887598281 1.19193446049341 0.425925925925926 20.1 20 1 impaired limb coordination 0.00691712559847481 0.0548846887598281 1.19193446049341 0.425925925925926 20.1 20 1 abnormal neuronal precursor proliferation 0.00691712559847481 0.0548846887598281 1.19193446049341 0.425925925925926 20.1 20 1 abnormal osteoblast physiology 0.00691712559847481 0.0548846887598281 1.19193446049341 0.425925925925926 20.1 20 1 decreased bone trabecula number 0.0114942100939173 0.0811116244216151 1.1908318384208 0.425531914893617 20.1 20 1 decreased percent body fat/body weight 0.00200592432783453 0.0212202215240719 1.18838492368432 0.424657534246575 20.1 20 1 abnormal locomotor coordination 0.0326760191468363 0.171299468130148 1.18722325709225 0.424242424242424 20.1 20 1 abnormal QRS complex 0.0326760191468363 0.171299468130148 1.18722325709225 0.424242424242424 20.1 20 1 abnormal thoracic vertebrae morphology 0.00540468454677678 0.0458844805805708 1.18578594080037 0.423728813559322 20.1 20 1 circling 0.000968801427664738 0.0123901982072804 1.18522792388706 0.423529411764706 20.1 20 1 increased susceptibility to injury 0.00894224439423302 0.0673480795916379 1.1839616547376 0.423076923076923 20.1 20 1 abnormal nasal bone morphology 0.0563745203807305 0.248597250361495 1.1839616547376 0.423076923076923 20.1 20 1 abnormal xiphoid process morphology 0.0563745203807305 0.248597250361495 1.1839616547376 0.423076923076923 20.1 20 1 no spontaneous movement 0.0563745203807305 0.248597250361495 1.1839616547376 0.423076923076923 20.1 20 1 pulmonary edema 0.0563745203807305 0.248597250361495 1.1839616547376 0.423076923076923 20.1 20 1 abnormal cornea morphology 0.00157751429658821 0.0176362553382614 1.1839616547376 0.423076923076923 20.1 20 1 abnormal kidney morphology 3.28005222286593e-06 0.000116558998633986 1.18334660972216 0.422857142857143 20.1 20 1 abnormal skeletal muscle fiber morphology 0.00257715150286872 0.0263813348287487 1.18244569871361 0.422535211267606 20.1 20 1 altered response to myocardial infarction 0.0149030270356485 0.0962675656328932 1.18156981301086 0.422222222222222 20.1 20 1 decreased total body fat amount 1.90767940351934e-10 1.86092255539387e-08 1.18138362173872 0.422155688622754 20.1 20 1 short tail 0.00124111080272559 0.0147715938841143 1.18007130976037 0.421686746987952 20.1 20 1 azoospermia 1.06871685155689e-05 0.000328201625709601 1.1792231003733 0.421383647798742 20.1 20 1 decreased birth weight 0.000602105622939138 0.00823035054874471 1.17829676643742 0.421052631578947 20.1 20 1 abnormal frontal bone morphology 0.0250770119837341 0.138080083127123 1.17829676643742 0.421052631578947 20.1 20 1 kyphoscoliosis 0.0999241611642526 0.339811425884232 1.17829676643742 0.421052631578947 20.1 20 1 abnormal triglyceride level 0.0999241611642526 0.339811425884232 1.17829676643742 0.421052631578947 20.1 20 1 irregular coat pigmentation 0.0999241611642526 0.339811425884232 1.17829676643742 0.421052631578947 20.1 20 1 shiny skin 0.0999241611642526 0.339811425884232 1.17829676643742 0.421052631578947 20.1 20 1 thin dermal layer 0.0999241611642526 0.339811425884232 1.17829676643742 0.421052631578947 20.1 20 1 unresponsive to tactile stimuli 0.0999241611642526 0.339811425884232 1.17829676643742 0.421052631578947 20.1 20 1 decreased tumor incidence 0.0999241611642526 0.339811425884232 1.17829676643742 0.421052631578947 20.1 20 1 Leydig cell hypoplasia 0.0999241611642526 0.339811425884232 1.17829676643742 0.421052631578947 20.1 20 1 decreased fertilization frequency 0.0999241611642526 0.339811425884232 1.17829676643742 0.421052631578947 20.1 20 1 increased monocyte cell number 0.000474866076588756 0.00690777406733644 1.17535102452133 0.42 20.1 20 1 kidney inflammation 0.0115539633164934 0.0813026414420856 1.17535102452133 0.42 20.1 20 1 decreased circulating alkaline phosphatase level 0.0115539633164934 0.0813026414420856 1.17535102452133 0.42 20.1 20 1 postnatal lethality, complete penetrance 1.54249396628172e-11 1.87168475176867e-09 1.17448103856684 0.419689119170984 20.1 20 1 osteopetrosis 0.0427624076653036 0.208981314474347 1.17354556979856 0.419354838709677 20.1 20 1 abnormal object recognition memory 0.0427624076653036 0.208981314474347 1.17354556979856 0.419354838709677 20.1 20 1 abnormal retinal photoreceptor layer morphology 0.0427624076653036 0.208981314474347 1.17354556979856 0.419354838709677 20.1 20 1 decreased neuronal precursor cell number 0.0427624076653036 0.208981314474347 1.17354556979856 0.419354838709677 20.1 20 1 increased circulating calcium level 0.00897523151140822 0.0673480795916379 1.17026292484808 0.418181818181818 20.1 20 1 abnormal embryo turning 0.00897523151140822 0.0673480795916379 1.17026292484808 0.418181818181818 20.1 20 1 small ovary 0.000981916792329144 0.0125257334406089 1.1685855293514 0.417582417582418 20.1 20 1 abnormal testis morphology 0.00023333553071358 0.00394844988197299 1.16805070759884 0.417391304347826 20.1 20 1 curly tail 0.0149190538900423 0.0962675656328932 1.16602284178703 0.416666666666667 20.1 20 1 abnormal osteoclast morphology 0.0149190538900423 0.0962675656328932 1.16602284178703 0.416666666666667 20.1 20 1 abnormal primitive streak formation 0.0743727323662213 0.274341377900798 1.16602284178703 0.416666666666667 20.1 20 1 abnormal cardiac muscle contractility 0.0743727323662213 0.274341377900798 1.16602284178703 0.416666666666667 20.1 20 1 abnormal tumor morphology 0.0743727323662213 0.274341377900798 1.16602284178703 0.416666666666667 20.1 20 1 abnormal adipose tissue distribution 0.186180452523219 0.491448464881069 1.16602284178703 0.416666666666667 20.1 20 1 decreased digestive secretion 0.186180452523219 0.491448464881069 1.16602284178703 0.416666666666667 20.1 20 1 abnormal enteric nervous system morphology 0.186180452523219 0.491448464881069 1.16602284178703 0.416666666666667 20.1 20 1 abnormal glossopharyngeal nerve morphology 0.186180452523219 0.491448464881069 1.16602284178703 0.416666666666667 20.1 20 1 impaired embryo implantation 0.186180452523219 0.491448464881069 1.16602284178703 0.416666666666667 20.1 20 1 increased papilloma incidence 0.186180452523219 0.491448464881069 1.16602284178703 0.416666666666667 20.1 20 1 abnormal tracheal ciliated epithelium morphology 0.186180452523219 0.491448464881069 1.16602284178703 0.416666666666667 20.1 20 1 abnormal corticospinal tract morphology 0.186180452523219 0.491448464881069 1.16602284178703 0.416666666666667 20.1 20 1 small thyroid gland 0.186180452523219 0.491448464881069 1.16602284178703 0.416666666666667 20.1 20 1 abnormal vascular endothelial cell development 0.186180452523219 0.491448464881069 1.16602284178703 0.416666666666667 20.1 20 1 absent ovary 0.186180452523219 0.491448464881069 1.16602284178703 0.416666666666667 20.1 20 1 small parietal bone 0.186180452523219 0.491448464881069 1.16602284178703 0.416666666666667 20.1 20 1 increased placenta weight 0.186180452523219 0.491448464881069 1.16602284178703 0.416666666666667 20.1 20 1 abnormal amacrine cell morphology 0.186180452523219 0.491448464881069 1.16602284178703 0.416666666666667 20.1 20 1 abnormal palatine bone morphology 0.186180452523219 0.491448464881069 1.16602284178703 0.416666666666667 20.1 20 1 abnormal fatty acid level 0.186180452523219 0.491448464881069 1.16602284178703 0.416666666666667 20.1 20 1 hemoperitoneum 0.186180452523219 0.491448464881069 1.16602284178703 0.416666666666667 20.1 20 1 increased fibrosarcoma incidence 0.186180452523219 0.491448464881069 1.16602284178703 0.416666666666667 20.1 20 1 increased type II pneumocyte number 0.186180452523219 0.491448464881069 1.16602284178703 0.416666666666667 20.1 20 1 decreased compensatory feeding amount 0.186180452523219 0.491448464881069 1.16602284178703 0.416666666666667 20.1 20 1 abnormal colon goblet cell morphology 0.186180452523219 0.491448464881069 1.16602284178703 0.416666666666667 20.1 20 1 abnormal eating behavior 0.00698424075524515 0.0549787939198491 1.16602284178703 0.416666666666667 20.1 20 1 increased erythrocyte cell number 0.00698424075524515 0.0549787939198491 1.16602284178703 0.416666666666667 20.1 20 1 head tilt 0.0326294049610591 0.171299468130148 1.16602284178703 0.416666666666667 20.1 20 1 ataxia 1.69204051299658e-06 6.47530888627537e-05 1.16371388566468 0.415841584158416 20.1 20 1 increased body weight 5.3042994375101e-07 2.39898997287389e-05 1.16185847449494 0.415178571428571 20.1 20 1 abnormal retina morphology 1.34645292502058e-06 5.24323658940473e-05 1.15935985411968 0.414285714285714 20.1 20 1 increased leukocyte cell number 5.67159848014448e-05 0.00126530055779008 1.15798130494712 0.413793103448276 20.1 20 1 abnormal spermiogenesis 0.00896731474810839 0.0673480795916379 1.15798130494712 0.413793103448276 20.1 20 1 abnormal parietal bone morphology 0.0559585607084453 0.248597250361495 1.15798130494712 0.413793103448276 20.1 20 1 aphagia 0.0559585607084453 0.248597250361495 1.15798130494712 0.413793103448276 20.1 20 1 abnormal outer ear morphology 0.0559585607084453 0.248597250361495 1.15798130494712 0.413793103448276 20.1 20 1 decreased bone strength 0.0559585607084453 0.248597250361495 1.15798130494712 0.413793103448276 20.1 20 1 increased retinal apoptosis 0.0559585607084453 0.248597250361495 1.15798130494712 0.413793103448276 20.1 20 1 impaired coordination 8.1979902224902e-10 6.79750022614812e-08 1.15658681878991 0.413294797687861 20.1 20 1 abnormal hair follicle morphology 0.00697309265891452 0.0549787939198491 1.15491786234144 0.412698412698413 20.1 20 1 gliosis 0.00697309265891452 0.0549787939198491 1.15491786234144 0.412698412698413 20.1 20 1 abnormal glucose homeostasis 8.70138810694114e-06 0.000277496191230976 1.1532094039652 0.412087912087912 20.1 20 1 abnormal cervical vertebrae morphology 0.0148609551213426 0.0962672548550516 1.1523049260013 0.411764705882353 20.1 20 1 abnormal brown adipose tissue morphology 0.0424363476208719 0.208617420369405 1.1523049260013 0.411764705882353 20.1 20 1 increased width of hypertrophic chondrocyte zone 0.0424363476208719 0.208617420369405 1.1523049260013 0.411764705882353 20.1 20 1 abnormal nervous system development 0.0424363476208719 0.208617420369405 1.1523049260013 0.411764705882353 20.1 20 1 decreased osteoblast cell number 0.0424363476208719 0.208617420369405 1.1523049260013 0.411764705882353 20.1 20 1 hyperlipidemia 0.133605002343894 0.414650584317452 1.1523049260013 0.411764705882353 20.1 20 1 abnormal duodenum morphology 0.133605002343894 0.414650584317452 1.1523049260013 0.411764705882353 20.1 20 1 abnormal melanosome morphology 0.133605002343894 0.414650584317452 1.1523049260013 0.411764705882353 20.1 20 1 enhanced behavioral response to cocaine 0.133605002343894 0.414650584317452 1.1523049260013 0.411764705882353 20.1 20 1 abnormal circulating chemokine level 0.133605002343894 0.414650584317452 1.1523049260013 0.411764705882353 20.1 20 1 abnormal dendritic cell physiology 0.000608080731126223 0.00823035054874471 1.15076646815618 0.411214953271028 20.1 20 1 decreased startle reflex 0.000376589506436585 0.00585478998288129 1.14808402883646 0.41025641025641 20.1 20 1 increased circulating alanine transaminase level 0.00330931476758634 0.0320932572490099 1.14808402883646 0.41025641025641 20.1 20 1 increased double-negative T cell number 0.00892448033370378 0.0673480795916379 1.14690771323315 0.409836065573771 20.1 20 1 abnormal tail morphology 0.0069374880477116 0.0549586035626834 1.14482242648182 0.409090909090909 20.1 20 1 decreased cardiac output 0.0981737808305855 0.339811425884232 1.14482242648182 0.409090909090909 20.1 20 1 abnormal retinal layer morphology 0.0981737808305855 0.339811425884232 1.14482242648182 0.409090909090909 20.1 20 1 prolonged PR interval 0.0981737808305855 0.339811425884232 1.14482242648182 0.409090909090909 20.1 20 1 failure of palatal shelf elevation 0.0981737808305855 0.339811425884232 1.14482242648182 0.409090909090909 20.1 20 1 decreased leukocyte cell number 0.000145230514909285 0.00272649740254224 1.14389394113998 0.408759124087591 20.1 20 1 organ of Corti degeneration 0.019096621181882 0.110471732999841 1.14222645726077 0.408163265306122 20.1 20 1 abnormal epidermis stratum corneum morphology 0.019096621181882 0.110471732999841 1.14222645726077 0.408163265306122 20.1 20 1 abnormal axial skeleton morphology 0.0042130071274519 0.0385288795203552 1.14147499248625 0.407894736842105 20.1 20 1 abnormal liver morphology 1.74274281514428e-05 0.000487715286601394 1.14126928425189 0.407821229050279 20.1 20 1 abnormal lipid homeostasis 0.000232708402863264 0.00394844988197299 1.14090850365624 0.407692307692308 20.1 20 1 increased sensitivity to induced morbidity/mortality 1.37805260553911e-05 0.000398593704218433 1.14067451913949 0.407608695652174 20.1 20 1 decreased tumor growth/size 0.0147415780927002 0.0962672548550516 1.14011122308066 0.407407407407407 20.1 20 1 abnormal trigeminal ganglion morphology 0.0732119037530131 0.27344536123967 1.14011122308066 0.407407407407407 20.1 20 1 wrinkled skin 0.0732119037530131 0.27344536123967 1.14011122308066 0.407407407407407 20.1 20 1 increased bone mineral density 0.000603113423502251 0.00823035054874471 1.13919399763972 0.407079646017699 20.1 20 1 abnormal colon morphology 0.0114102611718786 0.08074829207695 1.13835450316836 0.406779661016949 20.1 20 1 decreased circulating HDL cholesterol level 0.000293786716018563 0.00480785826379062 1.13687227074236 0.40625 20.1 20 1 decreased lymphocyte cell number 0.000293786716018563 0.00480785826379062 1.13687227074236 0.40625 20.1 20 1 increased sacral vertebrae number 0.00885199555153406 0.0669280818676017 1.13687227074236 0.40625 20.1 20 1 increased circulating follicle stimulating hormone level 0.0551560759820787 0.248597250361495 1.13687227074236 0.40625 20.1 20 1 abnormal lumbar vertebrae morphology 0.0551560759820787 0.248597250361495 1.13687227074236 0.40625 20.1 20 1 abnormal depression-related behavior 0.0551560759820787 0.248597250361495 1.13687227074236 0.40625 20.1 20 1 decreased circulating chloride level 0.0418659687433878 0.207453380974456 1.13450871092793 0.405405405405405 20.1 20 1 hunched posture 0.00417839715904382 0.0382827364019208 1.13355131961069 0.40506329113924 20.1 20 1 respiratory distress 3.47244665191206e-05 0.000845269193168798 1.13232275965446 0.404624277456647 20.1 20 1 decreased circulating cholesterol level 2.16749690039878e-05 0.000571132342438872 1.13161561039004 0.404371584699454 20.1 20 1 neuron degeneration 0.0245129974908346 0.136717670983074 1.13129024649976 0.404255319148936 20.1 20 1 cachexia 0.00122654763101073 0.0146810839150826 1.13014521588589 0.403846153846154 20.1 20 1 abnormal trabecular bone morphology 0.000593996297203176 0.00816595386381638 1.12878849894005 0.403361344537815 20.1 20 1 increased eosinophil cell number 0.011281973371018 0.0802973068967302 1.12840920172939 0.403225806451613 20.1 20 1 no abnormal phenotype detected 8.53930151655321e-39 8.49660500897044e-36 1.12744663941321 0.402881844380403 20.1 20 1 abnormal response/metabolism to endogenous compounds 0.00413443408967937 0.0380199807692327 1.12620742767723 0.402439024390244 20.1 20 1 increased or absent threshold for auditory brainstem response 1.97858200147952e-07 1.08569253479125e-05 1.12325522198446 0.401384083044983 20.1 20 1 abnormal intestinal goblet cell morphology 0.05408091087368 0.247974683499132 1.11938192811555 0.4 20.1 20 1 decreased triglyceride level 0.05408091087368 0.247974683499132 1.11938192811555 0.4 20.1 20 1 decreased bone mineralization 0.05408091087368 0.247974683499132 1.11938192811555 0.4 20.1 20 1 abnormal circulating enzyme level 0.129649804680735 0.413931803710415 1.11938192811555 0.4 20.1 20 1 anencephaly 0.129649804680735 0.413931803710415 1.11938192811555 0.4 20.1 20 1 abnormal hyoid bone morphology 0.129649804680735 0.413931803710415 1.11938192811555 0.4 20.1 20 1 abnormal hindlimb morphology 0.0241250597588078 0.134856373370864 1.11938192811555 0.4 20.1 20 1 testicular atrophy 0.0241250597588078 0.134856373370864 1.11938192811555 0.4 20.1 20 1 abnormal circulating protein level 0.0241250597588078 0.134856373370864 1.11938192811555 0.4 20.1 20 1 abnormal response to new environment 0.0716283423135124 0.270372536426195 1.11938192811555 0.4 20.1 20 1 salivary gland inflammation 0.0716283423135124 0.270372536426195 1.11938192811555 0.4 20.1 20 1 abnormal lactation 0.0716283423135124 0.270372536426195 1.11938192811555 0.4 20.1 20 1 ruffled hair 0.0957460031605937 0.334740945694978 1.11938192811555 0.4 20.1 20 1 decreased chondrocyte number 0.179048774104367 0.491448464881069 1.11938192811555 0.4 20.1 20 1 abnormal Muller cell morphology 0.179048774104367 0.491448464881069 1.11938192811555 0.4 20.1 20 1 abnormal microglial cell activation 0.179048774104367 0.491448464881069 1.11938192811555 0.4 20.1 20 1 increased spleen weight 0.00118439155152476 0.0144130948095839 1.11442891073451 0.398230088495575 20.1 20 1 improved glucose tolerance 2.5826980570138e-05 0.000662315609981631 1.11367079582925 0.397959183673469 20.1 20 1 hyperglycemia 0.00402348988689907 0.0372753485797447 1.11302180352399 0.397727272727273 20.1 20 1 small kidney 0.00402348988689907 0.0372753485797447 1.11302180352399 0.397727272727273 20.1 20 1 absent gastric milk in neonates 0.00661436674750431 0.0533330219916271 1.11220640293532 0.397435897435897 20.1 20 1 abnormal fertility/fecundity 0.00850000710557666 0.0644627063265913 1.11171492860791 0.397260273972603 20.1 20 1 lung inflammation 0.000445495607029394 0.00659625191955724 1.11115117864411 0.397058823529412 20.1 20 1 oligodactyly 0.0307986846775605 0.164041862166911 1.10772169969768 0.395833333333333 20.1 20 1 abnormal locomotor activation 0.00395871658219147 0.0368123644792571 1.10708102780659 0.395604395604396 20.1 20 1 abnormal axon guidance 0.0402321345992074 0.200958704448852 1.10636585918398 0.395348837209302 20.1 20 1 neonatal lethality, complete penetrance 4.94449920675543e-10 4.39265777743004e-08 1.10465321853508 0.394736842105263 20.1 20 1 abnormal retinal outer nuclear layer morphology 0.052815288369249 0.244651824615469 1.10465321853508 0.394736842105263 20.1 20 1 decreased threshold for auditory brainstem response 0.052815288369249 0.244651824615469 1.10465321853508 0.394736842105263 20.1 20 1 increased circulating free fatty acid level 0.010741704266559 0.0775616527229771 1.10361598546604 0.394366197183099 20.1 20 1 insulin resistance 0.000697874311038724 0.00923199103338163 1.10242159587138 0.393939393939394 20.1 20 1 abnormal motor coordination/ balance 0.00304180931806984 0.0301454210306722 1.10242159587138 0.393939393939394 20.1 20 1 deafness 0.00304180931806984 0.0301454210306722 1.10242159587138 0.393939393939394 20.1 20 1 absent vibrissae 0.0697681129249861 0.264152482345362 1.10242159587138 0.393939393939394 20.1 20 1 abnormal male meiosis 0.0178872946059133 0.109738543067127 1.10103140470382 0.39344262295082 20.1 20 1 straub tail 0.0929165414377929 0.329479539310777 1.09939296511349 0.392857142857143 20.1 20 1 abnormal hormone level 0.0929165414377929 0.329479539310777 1.09939296511349 0.392857142857143 20.1 20 1 abnormal brainstem morphology 0.0929165414377929 0.329479539310777 1.09939296511349 0.392857142857143 20.1 20 1 infertility 0.00233876810396496 0.0242909630839784 1.0984589014218 0.392523364485981 20.1 20 1 cochlear inner hair cell degeneration 0.0301019014603983 0.160856025526833 1.09743326285838 0.392156862745098 20.1 20 1 abnormal sternum morphology 0.0135540811661599 0.0905121527538866 1.09504753837391 0.391304347826087 20.1 20 1 abnormal epidermal layer morphology 0.0135540811661599 0.0905121527538866 1.09504753837391 0.391304347826087 20.1 20 1 abnormal coat appearance 0.0135540811661599 0.0905121527538866 1.09504753837391 0.391304347826087 20.1 20 1 abnormal forelimb morphology 0.0392542349372533 0.197246808782917 1.09504753837391 0.391304347826087 20.1 20 1 delayed wound healing 0.0392542349372533 0.197246808782917 1.09504753837391 0.391304347826087 20.1 20 1 fragile skeleton 0.125128860471553 0.400847444202173 1.09504753837391 0.391304347826087 20.1 20 1 abnormal circulating insulin level 0.125128860471553 0.400847444202173 1.09504753837391 0.391304347826087 20.1 20 1 failure of embryo implantation 0.125128860471553 0.400847444202173 1.09504753837391 0.391304347826087 20.1 20 1 abnormal cochlear ganglion morphology 0.125128860471553 0.400847444202173 1.09504753837391 0.391304347826087 20.1 20 1 decreased epididymis weight 0.125128860471553 0.400847444202173 1.09504753837391 0.391304347826087 20.1 20 1 abnormal hepatocyte physiology 0.125128860471553 0.400847444202173 1.09504753837391 0.391304347826087 20.1 20 1 increased sensitivity to xenobiotic induced morbidity/mortality 0.00229399617589163 0.0240265915264439 1.09394142974929 0.390909090909091 20.1 20 1 abnormal spleen morphology 0.000155594103290127 0.00287762328575607 1.09364901022784 0.390804597701149 20.1 20 1 decreased eosinophil cell number 0.0174916144424588 0.10959796202926 1.09314641417534 0.390625 20.1 20 1 abnormal cholesterol homeostasis 0.0514194183499846 0.239076267561844 1.09207992986883 0.390243902439024 20.1 20 1 abnormal cytokine secretion 0.000401952821009947 0.00613409596479904 1.09030707283982 0.38961038961039 20.1 20 1 diluted coat color 0.029354833514201 0.157371009410722 1.0882879856679 0.388888888888889 20.1 20 1 decreased platelet aggregation 0.029354833514201 0.157371009410722 1.0882879856679 0.388888888888889 20.1 20 1 abnormal digit morphology 0.0132459779541057 0.0888123184928246 1.0882879856679 0.388888888888889 20.1 20 1 cochlear outer hair cell degeneration 0.0132459779541057 0.0888123184928246 1.0882879856679 0.388888888888889 20.1 20 1 reduced long term depression 0.0677318691817118 0.262590252228645 1.0882879856679 0.388888888888889 20.1 20 1 impaired wound healing 0.0677318691817118 0.262590252228645 1.0882879856679 0.388888888888889 20.1 20 1 abnormal heart shape 0.171252662197043 0.473797474053114 1.0882879856679 0.388888888888889 20.1 20 1 right pulmonary isomerism 0.171252662197043 0.473797474053114 1.0882879856679 0.388888888888889 20.1 20 1 abnormal radius morphology 0.171252662197043 0.473797474053114 1.0882879856679 0.388888888888889 20.1 20 1 abnormal Peyer's patch follicle morphology 0.171252662197043 0.473797474053114 1.0882879856679 0.388888888888889 20.1 20 1 small thoracic cage 0.171252662197043 0.473797474053114 1.0882879856679 0.388888888888889 20.1 20 1 increased effector memory CD4-positive, alpha-beta T cell number 0.171252662197043 0.473797474053114 1.0882879856679 0.388888888888889 20.1 20 1 impaired leukocyte tethering or rolling 0.171252662197043 0.473797474053114 1.0882879856679 0.388888888888889 20.1 20 1 impaired glucose tolerance 1.27254068140172e-05 0.000376838683926999 1.08327283366021 0.387096774193548 20.1 20 1 small cranium 0.089859458933434 0.320466529171207 1.08327283366021 0.387096774193548 20.1 20 1 increased circulating triglyceride level 0.000787577593775781 0.0103382546940225 1.08078255128398 0.386206896551724 20.1 20 1 abnormal rib morphology 0.00126998640266724 0.0148314139748111 1.07792333818535 0.385185185185185 20.1 20 1 absent corpus luteum 0.0371215871709108 0.187873749923989 1.07632877703419 0.384615384615385 20.1 20 1 increased susceptibility to otitis media 0.120353179898009 0.387044001288036 1.07632877703419 0.384615384615385 20.1 20 1 increased leukemia incidence 0.120353179898009 0.387044001288036 1.07632877703419 0.384615384615385 20.1 20 1 abnormal ocular fundus morphology 0.120353179898009 0.387044001288036 1.07632877703419 0.384615384615385 20.1 20 1 decreased Peyer's patch number 0.120353179898009 0.387044001288036 1.07632877703419 0.384615384615385 20.1 20 1 short premaxilla 0.240516341105637 0.543011236413147 1.07632877703419 0.384615384615385 20.1 20 1 short hair 0.240516341105637 0.543011236413147 1.07632877703419 0.384615384615385 20.1 20 1 excessive scratching 0.240516341105637 0.543011236413147 1.07632877703419 0.384615384615385 20.1 20 1 abnormal lung interstitium morphology 0.240516341105637 0.543011236413147 1.07632877703419 0.384615384615385 20.1 20 1 increased synaptic depression 0.240516341105637 0.543011236413147 1.07632877703419 0.384615384615385 20.1 20 1 abnormal insulin secretion 0.240516341105637 0.543011236413147 1.07632877703419 0.384615384615385 20.1 20 1 abnormal retinal inner plexiform layer morphology 0.240516341105637 0.543011236413147 1.07632877703419 0.384615384615385 20.1 20 1 abnormal exocrine pancreas morphology 0.240516341105637 0.543011236413147 1.07632877703419 0.384615384615385 20.1 20 1 abnormal hair follicle inner root sheath morphology 0.240516341105637 0.543011236413147 1.07632877703419 0.384615384615385 20.1 20 1 small lens 0.0655901946975686 0.262590252228645 1.07632877703419 0.384615384615385 20.1 20 1 abnormal neuron differentiation 0.00340857679334553 0.0329915749939572 1.07440676136091 0.383928571428571 20.1 20 1 female infertility 1.11604878954042e-05 0.000338557483412413 1.07309169800551 0.383458646616541 20.1 20 1 hepatic necrosis 0.0484039685246857 0.227179003217275 1.07174865457872 0.382978723404255 20.1 20 1 abnormal innervation 0.0484039685246857 0.227179003217275 1.07174865457872 0.382978723404255 20.1 20 1 abnormal skeleton development 0.012261574057862 0.0854360377280998 1.07101357319698 0.382716049382716 20.1 20 1 abnormal oocyte morphology 0.0866877771608664 0.309821617367321 1.06999743128693 0.382352941176471 20.1 20 1 impaired synaptic plasticity 0.0866877771608664 0.309821617367321 1.06999743128693 0.382352941176471 20.1 20 1 abnormal learning/memory/conditioning 0.0360062897410667 0.183160829715549 1.06850093138303 0.381818181818182 20.1 20 1 decreased IgM level 0.00708041291946235 0.0556477950621251 1.06745183866689 0.381443298969072 20.1 20 1 increased food intake 0.0119231353872398 0.083781918858076 1.06607802677672 0.380952380952381 20.1 20 1 abnormal vibrissa morphology 0.0633932324093591 0.262590252228645 1.06607802677672 0.380952380952381 20.1 20 1 abnormal spleen white pulp morphology 0.0633932324093591 0.262590252228645 1.06607802677672 0.380952380952381 20.1 20 1 abnormal cytotoxic T cell physiology 0.0633932324093591 0.262590252228645 1.06607802677672 0.380952380952381 20.1 20 1 increased incidence of induced tumors 0.16334568357341 0.473797474053114 1.06607802677672 0.380952380952381 20.1 20 1 abnormal associative learning 0.16334568357341 0.473797474053114 1.06607802677672 0.380952380952381 20.1 20 1 abnormal erythrocyte physiology 0.16334568357341 0.473797474053114 1.06607802677672 0.380952380952381 20.1 20 1 decreased cochlear outer hair cell number 0.16334568357341 0.473797474053114 1.06607802677672 0.380952380952381 20.1 20 1 decreased litter size 9.90479341968195e-06 0.000307977170393236 1.06560379277904 0.380782918149466 20.1 20 1 increased total body fat amount 0.00190113135685306 0.0204279233268769 1.06508355100547 0.380597014925373 20.1 20 1 abnormal locomotor behavior 0.00905117378164534 0.0678156469332614 1.06462955119686 0.380434782608696 20.1 20 1 decreased heart rate 0.00688689075036781 0.0548846887598281 1.06341283170977 0.38 20.1 20 1 abnormal axon extension 0.0468426916932417 0.22047529912382 1.06341283170977 0.38 20.1 20 1 abnormal middle ear morphology 0.115501974105728 0.380648738512146 1.0614828628682 0.379310344827586 20.1 20 1 focal hair loss 0.115501974105728 0.380648738512146 1.0614828628682 0.379310344827586 20.1 20 1 abnormal CD8-positive, alpha-beta T cell physiology 0.115501974105728 0.380648738512146 1.0614828628682 0.379310344827586 20.1 20 1 enlarged epididymis 0.115501974105728 0.380648738512146 1.0614828628682 0.379310344827586 20.1 20 1 polychromatophilia 0.115501974105728 0.380648738512146 1.0614828628682 0.379310344827586 20.1 20 1 abnormal skin morphology 0.0261206049869474 0.141712115387201 1.06002076526094 0.378787878787879 20.1 20 1 decreased osteoclast cell number 0.0611769202095069 0.255331525203269 1.05719404322024 0.377777777777778 20.1 20 1 seizures 0.00495839307689733 0.0425310440647659 1.05555751993353 0.37719298245614 20.1 20 1 abnormal blood homeostasis 0.00495839307689733 0.0425310440647659 1.05555751993353 0.37719298245614 20.1 20 1 obese 0.0190439484371934 0.110471732999841 1.05396350374516 0.376623376623377 20.1 20 1 abnormal definitive hematopoiesis 0.0109061685438159 0.0786350558050492 1.05318192161409 0.376344086021505 20.1 20 1 decreased caudal vertebrae number 0.0326196773286817 0.171299468130148 1.04942055760833 0.375 20.1 20 1 abnormal vertebral body morphology 0.110681488704247 0.372054328583534 1.04942055760833 0.375 20.1 20 1 scoliosis 0.110681488704247 0.372054328583534 1.04942055760833 0.375 20.1 20 1 neonatal lethality 0.110681488704247 0.372054328583534 1.04942055760833 0.375 20.1 20 1 abnormal long term potentiation 0.110681488704247 0.372054328583534 1.04942055760833 0.375 20.1 20 1 abnormal tympanic ring morphology 0.226152118699458 0.543011236413147 1.04942055760833 0.375 20.1 20 1 absent mandible 0.226152118699458 0.543011236413147 1.04942055760833 0.375 20.1 20 1 failure of tooth eruption 0.226152118699458 0.543011236413147 1.04942055760833 0.375 20.1 20 1 decreased mast cell number 0.226152118699458 0.543011236413147 1.04942055760833 0.375 20.1 20 1 reduced male mating frequency 0.226152118699458 0.543011236413147 1.04942055760833 0.375 20.1 20 1 poor circulation 0.226152118699458 0.543011236413147 1.04942055760833 0.375 20.1 20 1 intraventricular hemorrhage 0.226152118699458 0.543011236413147 1.04942055760833 0.375 20.1 20 1 small epididymis 0.226152118699458 0.543011236413147 1.04942055760833 0.375 20.1 20 1 abnormal level of surface class II molecules 0.226152118699458 0.543011236413147 1.04942055760833 0.375 20.1 20 1 sepsis 0.226152118699458 0.543011236413147 1.04942055760833 0.375 20.1 20 1 abnormal pulmonary alveolus wall morphology 0.226152118699458 0.543011236413147 1.04942055760833 0.375 20.1 20 1 enhanced long term potentiation 0.0437088692411983 0.211118082014526 1.04942055760833 0.375 20.1 20 1 abnormal cardiovascular system morphology 0.0589671388329608 0.250095068792822 1.04942055760833 0.375 20.1 20 1 hemolytic anemia 0.155582537334752 0.468253553079486 1.04942055760833 0.375 20.1 20 1 abnormal vasodilation 0.155582537334752 0.468253553079486 1.04942055760833 0.375 20.1 20 1 abnormal cellular extravasation 0.155582537334752 0.468253553079486 1.04942055760833 0.375 20.1 20 1 abnormal truncus arteriosus septation 0.155582537334752 0.468253553079486 1.04942055760833 0.375 20.1 20 1 syndactyly 0.0421612943447492 0.208501430780445 1.04349162790433 0.372881355932203 20.1 20 1 increased B cell proliferation 0.0421612943447492 0.208501430780445 1.04349162790433 0.372881355932203 20.1 20 1 abnormal response to novel object 0.0567825358939926 0.248597250361495 1.04256159971547 0.372549019607843 20.1 20 1 abnormal hippocampus pyramidal cell morphology 0.105955470876022 0.357375232276752 1.0394260761073 0.371428571428571 20.1 20 1 abnormal motor capabilities/coordination/movement 0.0041222400572341 0.0379780449717401 1.03882034995572 0.371212121212121 20.1 20 1 abnormal mandible morphology 0.0546364879193114 0.248597250361495 1.03646474825514 0.37037037037037 20.1 20 1 abnormal brain commissure morphology 0.148083342336241 0.447578753416039 1.03646474825514 0.37037037037037 20.1 20 1 decreased bone ossification 0.148083342336241 0.447578753416039 1.03646474825514 0.37037037037037 20.1 20 1 enlarged liver 0.0122107049190072 0.0852009214194403 1.03542828350689 0.37 20.1 20 1 abnormal inner ear morphology 0.0740281495070348 0.274341377900798 1.0342115640198 0.369565217391304 20.1 20 1 abnormal lymphocyte physiology 0.0740281495070348 0.274341377900798 1.0342115640198 0.369565217391304 20.1 20 1 increased circulating cholesterol level 0.00125551367986263 0.01479145836569 1.03352024612942 0.369318181818182 20.1 20 1 increased circulating insulin level 0.00212650257616057 0.0223193044649765 1.03193021498153 0.36875 20.1 20 1 small superior vagus ganglion 0.212860954466171 0.538648651306817 1.03100967063275 0.368421052631579 20.1 20 1 short vibrissae 0.212860954466171 0.538648651306817 1.03100967063275 0.368421052631579 20.1 20 1 abnormal nasal septum morphology 0.212860954466171 0.538648651306817 1.03100967063275 0.368421052631579 20.1 20 1 abnormal response to novelty 0.212860954466171 0.538648651306817 1.03100967063275 0.368421052631579 20.1 20 1 oliguria 0.212860954466171 0.538648651306817 1.03100967063275 0.368421052631579 20.1 20 1 eyelids fail to open 0.212860954466171 0.538648651306817 1.03100967063275 0.368421052631579 20.1 20 1 decreased circulating magnesium level 0.212860954466171 0.538648651306817 1.03100967063275 0.368421052631579 20.1 20 1 shortened RR interval 0.212860954466171 0.538648651306817 1.03100967063275 0.368421052631579 20.1 20 1 decreased urine osmolality 0.0710196759602662 0.268686606769828 1.02800381153469 0.36734693877551 20.1 20 1 abnormal lens morphology 0.00617754144099883 0.0501358379591667 1.02755762932482 0.3671875 20.1 20 1 reduced fertility 0.00456507625841095 0.0407742448574407 1.02677119305563 0.366906474820144 20.1 20 1 abnormal long bone epiphyseal plate morphology 0.0504951416455781 0.234998437499299 1.02610010077259 0.366666666666667 20.1 20 1 disorganized myocardium 0.140902497774905 0.427688950071965 1.02610010077259 0.366666666666667 20.1 20 1 abnormal T cell differentiation 0.0144792214620382 0.0951573669400794 1.02517651832365 0.366336633663366 20.1 20 1 abnormal skin condition 0.0681024760678879 0.262590252228645 1.02251233818248 0.365384615384615 20.1 20 1 decreased body temperature 0.0681024760678879 0.262590252228645 1.02251233818248 0.365384615384615 20.1 20 1 hydroencephaly 0.0102475267537743 0.0749727141176867 1.02204436914898 0.365217391304348 20.1 20 1 abnormal T cell activation 0.0348887044431941 0.177750560571625 1.02105783983513 0.364864864864865 20.1 20 1 abnormal urine homeostasis 0.0184061215433619 0.110471732999841 1.02026998656365 0.364583333333333 20.1 20 1 increased T cell number 0.0243262386743123 0.135828324808871 1.0176199346505 0.363636363636364 20.1 20 1 abnormal contextual conditioning behavior 0.0652823154497369 0.262590252228645 1.0176199346505 0.363636363636364 20.1 20 1 abnormal T-helper 2 physiology 0.0652823154497369 0.262590252228645 1.0176199346505 0.363636363636364 20.1 20 1 cochlear hair cell degeneration 0.0926500108152464 0.329238431289893 1.0176199346505 0.363636363636364 20.1 20 1 decreased blood urea nitrogen level 0.0926500108152464 0.329238431289893 1.0176199346505 0.363636363636364 20.1 20 1 abnormal aorta morphology 0.134060560578111 0.41528722844091 1.0176199346505 0.363636363636364 20.1 20 1 decreased systemic arterial blood pressure 0.134060560578111 0.41528722844091 1.0176199346505 0.363636363636364 20.1 20 1 cardiovascular system phenotype 0.134060560578111 0.41528722844091 1.0176199346505 0.363636363636364 20.1 20 1 abnormal oogenesis 0.200586770855025 0.512016000515008 1.0176199346505 0.363636363636364 20.1 20 1 abnormal chorion morphology 0.200586770855025 0.512016000515008 1.0176199346505 0.363636363636364 20.1 20 1 abnormal retinal outer plexiform layer morphology 0.200586770855025 0.512016000515008 1.0176199346505 0.363636363636364 20.1 20 1 abnormal circulating lipid level 0.200586770855025 0.512016000515008 1.0176199346505 0.363636363636364 20.1 20 1 abnormal limb posture 0.200586770855025 0.512016000515008 1.0176199346505 0.363636363636364 20.1 20 1 cleft upper lip 0.200586770855025 0.512016000515008 1.0176199346505 0.363636363636364 20.1 20 1 decreased circulating estradiol level 0.200586770855025 0.512016000515008 1.0176199346505 0.363636363636364 20.1 20 1 abnormal mesenteric lymph node morphology 0.200586770855025 0.512016000515008 1.0176199346505 0.363636363636364 20.1 20 1 abnormal B cell differentiation 0.0234102784463066 0.13230885563918 1.01482427548937 0.362637362637363 20.1 20 1 abnormal retinal pigment epithelium morphology 0.0322549353817306 0.169807728596941 1.01443987235472 0.3625 20.1 20 1 hyperkeratosis 0.0447297382547747 0.212289782722826 1.01393290590177 0.36231884057971 20.1 20 1 increased lymphocyte cell number 0.0447297382547747 0.212289782722826 1.01393290590177 0.36231884057971 20.1 20 1 cochlear ganglion degeneration 0.0625622494247729 0.26024012616074 1.01323364182873 0.362068965517241 20.1 20 1 abnormal enzyme/coenzyme level 0.0625622494247729 0.26024012616074 1.01323364182873 0.362068965517241 20.1 20 1 abnormal long bone morphology 0.0599433943574295 0.250732945081941 1.00927878764517 0.360655737704918 20.1 20 1 decreased T cell number 0.00417587219972411 0.0382827364019208 1.00813900358233 0.360248447204969 20.1 20 1 abnormal limb morphology 0.041204552219546 0.204692498812759 1.007443735304 0.36 20.1 20 1 increased body length 0.0846192296104677 0.302863789433149 1.007443735304 0.36 20.1 20 1 abnormal thyroid gland morphology 0.189240587807716 0.491448464881069 1.007443735304 0.36 20.1 20 1 increased pre-B cell number 0.189240587807716 0.491448464881069 1.007443735304 0.36 20.1 20 1 abnormal cochlear outer hair cell morphology 0.189240587807716 0.491448464881069 1.007443735304 0.36 20.1 20 1 increased rib number 0.0395375814826229 0.197687907413115 1.00457352523191 0.358974358974359 20.1 20 1 abnormal pancreatic islet morphology 0.0808601735158082 0.296885138923355 1.00321965255639 0.358490566037736 20.1 20 1 dehydration 0.0526867232093056 0.244511611908858 0.999448150103172 0.357142857142857 20.1 20 1 shortened head 0.178731565057601 0.491448464881069 0.999448150103172 0.357142857142857 20.1 20 1 abnormal ovulation 0.178731565057601 0.491448464881069 0.999448150103172 0.357142857142857 20.1 20 1 increased triglyceride level 0.178731565057601 0.491448464881069 0.999448150103172 0.357142857142857 20.1 20 1 corneal vascularization 0.178731565057601 0.491448464881069 0.999448150103172 0.357142857142857 20.1 20 1 abnormal kidney blood vessel morphology 0.298342770061867 0.570647935816142 0.999448150103172 0.357142857142857 20.1 20 1 increased aggression towards males 0.298342770061867 0.570647935816142 0.999448150103172 0.357142857142857 20.1 20 1 abnormal placing response 0.298342770061867 0.570647935816142 0.999448150103172 0.357142857142857 20.1 20 1 abnormal spleen periarteriolar lymphoid sheath morphology 0.298342770061867 0.570647935816142 0.999448150103172 0.357142857142857 20.1 20 1 abnormal endplate potential 0.298342770061867 0.570647935816142 0.999448150103172 0.357142857142857 20.1 20 1 intestinal obstruction 0.298342770061867 0.570647935816142 0.999448150103172 0.357142857142857 20.1 20 1 amyloid beta deposits 0.298342770061867 0.570647935816142 0.999448150103172 0.357142857142857 20.1 20 1 absent olfactory bulb 0.298342770061867 0.570647935816142 0.999448150103172 0.357142857142857 20.1 20 1 enlarged stomach 0.298342770061867 0.570647935816142 0.999448150103172 0.357142857142857 20.1 20 1 increased pulmonary respiratory rate 0.298342770061867 0.570647935816142 0.999448150103172 0.357142857142857 20.1 20 1 decreased tongue size 0.298342770061867 0.570647935816142 0.999448150103172 0.357142857142857 20.1 20 1 abnormal vitelline vein topology 0.298342770061867 0.570647935816142 0.999448150103172 0.357142857142857 20.1 20 1 short limbs 0.0349069945082367 0.177750560571625 0.997150568148912 0.35632183908046 20.1 20 1 abnormal gait 0.000193060306198583 0.00339075054781175 0.996213690070476 0.355987055016181 20.1 20 1 abnormal ovarian follicle morphology 0.110014474597723 0.370814370679996 0.995006158324936 0.355555555555556 20.1 20 1 abnormal cranial ganglia morphology 0.168976169137713 0.473797474053114 0.993000097521861 0.354838709677419 20.1 20 1 absent mature ovarian follicles 0.168976169137713 0.473797474053114 0.993000097521861 0.354838709677419 20.1 20 1 decreased susceptibility to bacterial infection induced morbidity/mortality 0.168976169137713 0.473797474053114 0.993000097521861 0.354838709677419 20.1 20 1 abnormal intestine physiology 0.168976169137713 0.473797474053114 0.993000097521861 0.354838709677419 20.1 20 1 decreased food intake 0.0462854850961576 0.218058985183129 0.99185740465935 0.354430379746835 20.1 20 1 decreased B cell number 0.00238499859714169 0.0247195167099581 0.991685446024701 0.354368932038835 20.1 20 1 thymus atrophy 0.104770565770879 0.35361842924703 0.991119415518979 0.354166666666667 20.1 20 1 abnormal CNS synaptic transmission 0.029539223459131 0.158018964203416 0.989352714243544 0.353535353535354 20.1 20 1 abnormal neuron morphology 0.029539223459131 0.158018964203416 0.989352714243544 0.353535353535354 20.1 20 1 abnormal cued conditioning behavior 0.0998028807285448 0.339811425884232 0.987689936572546 0.352941176470588 20.1 20 1 impaired hematopoiesis 0.0998028807285448 0.339811425884232 0.987689936572546 0.352941176470588 20.1 20 1 abnormal thrombosis 0.0998028807285448 0.339811425884232 0.987689936572546 0.352941176470588 20.1 20 1 abnormal retinal photoreceptor morphology 0.159900260623881 0.473797474053114 0.987689936572546 0.352941176470588 20.1 20 1 thin skin 0.159900260623881 0.473797474053114 0.987689936572546 0.352941176470588 20.1 20 1 absence seizures 0.276632363984312 0.547123763701174 0.987689936572546 0.352941176470588 20.1 20 1 increased regulatory T cell number 0.276632363984312 0.547123763701174 0.987689936572546 0.352941176470588 20.1 20 1 abnormal survival 0.276632363984312 0.547123763701174 0.987689936572546 0.352941176470588 20.1 20 1 abnormal electroretinogram waveform feature 0.276632363984312 0.547123763701174 0.987689936572546 0.352941176470588 20.1 20 1 abnormal suckling behavior 0.0406614406635288 0.202899365397248 0.985819311692674 0.352272727272727 20.1 20 1 abnormal CD4-positive, alpha-beta T cell physiology 0.0616097971285101 0.256922666147811 0.985371415594677 0.352112676056338 20.1 20 1 increased neutrophil cell number 0.0114682905576163 0.0810436726195189 0.984284109205055 0.351724137931034 20.1 20 1 increased insulin secretion 0.151438832183607 0.457165163903789 0.983240882804202 0.351351351351351 20.1 20 1 abnormal circulating amino acid level 0.0906346311760024 0.322999491476083 0.981913972031186 0.350877192982456 20.1 20 1 decreased neutrophil cell number 0.0229835240739627 0.130677751163388 0.98065510796448 0.35042735042735 20.1 20 1 head bobbing 0.143535034239534 0.434623734231091 0.979459187101108 0.35 20.1 20 1 abnormal skin pigmentation 0.143535034239534 0.434623734231091 0.979459187101108 0.35 20.1 20 1 abnormal Peyer's patch T cell area morphology 0.257666958196791 0.543011236413147 0.979459187101108 0.35 20.1 20 1 decreased paired-pulse facilitation 0.257666958196791 0.543011236413147 0.979459187101108 0.35 20.1 20 1 abnormal heart right ventricle morphology 0.257666958196791 0.543011236413147 0.979459187101108 0.35 20.1 20 1 abnormal postnatal subventricular zone morphology 0.257666958196791 0.543011236413147 0.979459187101108 0.35 20.1 20 1 abnormal incus morphology 0.257666958196791 0.543011236413147 0.979459187101108 0.35 20.1 20 1 nuclear cataracts 0.257666958196791 0.543011236413147 0.979459187101108 0.35 20.1 20 1 abnormal lipid level 0.0514856360554224 0.239160634337747 0.977773370944308 0.349397590361446 20.1 20 1 impaired swimming 0.0785867258846626 0.288751079229097 0.975219104040065 0.348484848484849 20.1 20 1 abnormal blood vessel physiology 0.24083098972621 0.543011236413147 0.973375589665698 0.347826086956522 20.1 20 1 bidirectional circling 0.24083098972621 0.543011236413147 0.973375589665698 0.347826086956522 20.1 20 1 pancreas inflammation 0.24083098972621 0.543011236413147 0.973375589665698 0.347826086956522 20.1 20 1 abnormal corneal stroma morphology 0.24083098972621 0.543011236413147 0.973375589665698 0.347826086956522 20.1 20 1 hyperactivity 0.000186488751991528 0.00333734367322968 0.973047632930635 0.347708894878706 20.1 20 1 abnormal brain wave pattern 0.116585447901834 0.380648738512146 0.968695899330767 0.346153846153846 20.1 20 1 increased percent body fat/body weight 0.116585447901834 0.380648738512146 0.968695899330767 0.346153846153846 20.1 20 1 abnormal kidney cortex morphology 0.225710391995208 0.543011236413147 0.968695899330767 0.346153846153846 20.1 20 1 decreased circulating glycerol level 0.225710391995208 0.543011236413147 0.968695899330767 0.346153846153846 20.1 20 1 decreased exploration in new environment 0.0594450656537803 0.250732945081941 0.9661332117664 0.345238095238095 20.1 20 1 abnormal circulating glucose level 0.212010297137535 0.538648651306817 0.964984420789269 0.344827586206897 20.1 20 1 decreased granulocyte number 0.212010297137535 0.538648651306817 0.964984420789269 0.344827586206897 20.1 20 1 short sternum 0.212010297137535 0.538648651306817 0.964984420789269 0.344827586206897 20.1 20 1 polydipsia 0.199511477936196 0.51189768062536 0.961968844474303 0.34375 20.1 20 1 rib fusion 0.0909123652391406 0.323525763279488 0.960663595024541 0.343283582089552 20.1 20 1 abnormal femur morphology 0.0909123652391406 0.323525763279488 0.960663595024541 0.343283582089552 20.1 20 1 increased bone marrow cell number 0.177478817095867 0.490259364270925 0.957366122730407 0.342105263157895 20.1 20 1 short humerus 0.167704306513117 0.473797474053114 0.955569938635228 0.341463414634146 20.1 20 1 lethality at weaning, incomplete penetrance 0.167704306513117 0.473797474053114 0.955569938635228 0.341463414634146 20.1 20 1 abnormal circadian rhythm 0.15863341513897 0.473797474053114 0.954018688734846 0.340909090909091 20.1 20 1 increased thermal nociceptive threshold 0.0621558890357407 0.258982870982253 0.953319773944564 0.340659340659341 20.1 20 1 increased circulating glucose level 0.0255204672587876 0.138607341279987 0.95266547073664 0.340425531914894 20.1 20 1 abnormal T-helper 1 physiology 0.150192297484314 0.453677401326328 0.95266547073664 0.340425531914894 20.1 20 1 abnormal vertebrae morphology 0.047201614349909 0.221954661049903 0.949934205052189 0.339449541284404 20.1 20 1 short mandible 0.128066020856342 0.409728909170613 0.949475742598013 0.339285714285714 20.1 20 1 abnormal seminal vesicle morphology 0.128066020856342 0.409728909170613 0.949475742598013 0.339285714285714 20.1 20 1 decreased susceptibility to injury 0.104435470068325 0.352726723414745 0.946536189215357 0.338235294117647 20.1 20 1 decreased T cell proliferation 0.0265094640022435 0.14366512354157 0.945423925773271 0.337837837837838 20.1 20 1 decreased IgG level 0.0605958752251845 0.253118790298315 0.932818273429627 0.333333333333333 20.1 20 1 abnormal retinal pigmentation 0.0884772984923439 0.315990351758371 0.932818273429627 0.333333333333333 20.1 20 1 polyphagia 0.154889724959302 0.467299200529126 0.932818273429627 0.333333333333333 20.1 20 1 abnormal metabolism 0.182942885409593 0.491448464881069 0.932818273429627 0.333333333333333 20.1 20 1 abnormal optic nerve morphology 0.193781239440788 0.497451840153727 0.932818273429627 0.333333333333333 20.1 20 1 small ears 0.304827595508481 0.581456505638601 0.932818273429627 0.333333333333333 20.1 20 1 abnormal clavicle morphology 0.304827595508481 0.581456505638601 0.932818273429627 0.333333333333333 20.1 20 1 abnormal inflammatory response 0.113273972021142 0.380255068019691 0.932818273429627 0.333333333333333 20.1 20 1 abnormal food intake 0.119166312530864 0.384220612340277 0.932818273429627 0.333333333333333 20.1 20 1 abnormal lens fiber morphology 0.205521168424295 0.52380523202401 0.932818273429627 0.333333333333333 20.1 20 1 abnormal leukocyte adhesion 0.205521168424295 0.52380523202401 0.932818273429627 0.333333333333333 20.1 20 1 increased autoantibody level 0.205521168424295 0.52380523202401 0.932818273429627 0.333333333333333 20.1 20 1 abnormal systemic arterial blood pressure 0.218287994821655 0.543011236413147 0.932818273429627 0.333333333333333 20.1 20 1 belly spot 0.232236936615239 0.543011236413147 0.932818273429627 0.333333333333333 20.1 20 1 dextrocardia 0.232236936615239 0.543011236413147 0.932818273429627 0.333333333333333 20.1 20 1 dilated heart atrium 0.232236936615239 0.543011236413147 0.932818273429627 0.333333333333333 20.1 20 1 abnormal malleus morphology 0.283455215921939 0.547123763701174 0.932818273429627 0.333333333333333 20.1 20 1 abnormal startle reflex 0.283455215921939 0.547123763701174 0.932818273429627 0.333333333333333 20.1 20 1 prolonged QT interval 0.283455215921939 0.547123763701174 0.932818273429627 0.333333333333333 20.1 20 1 abnormal retinal ganglion layer morphology 0.283455215921939 0.547123763701174 0.932818273429627 0.333333333333333 20.1 20 1 decreased fatty acid level 0.283455215921939 0.547123763701174 0.932818273429627 0.333333333333333 20.1 20 1 lowered ear position 0.329322214877946 0.616627030115838 0.932818273429627 0.333333333333333 20.1 20 1 abnormal retinal rod cell morphology 0.329322214877946 0.616627030115838 0.932818273429627 0.333333333333333 20.1 20 1 thick dermal layer 0.329322214877946 0.616627030115838 0.932818273429627 0.333333333333333 20.1 20 1 blepharoptosis 0.329322214877946 0.616627030115838 0.932818273429627 0.333333333333333 20.1 20 1 abnormal thyroid cartilage morphology 0.329322214877946 0.616627030115838 0.932818273429627 0.333333333333333 20.1 20 1 abnormal bile duct morphology 0.329322214877946 0.616627030115838 0.932818273429627 0.333333333333333 20.1 20 1 acidosis 0.329322214877946 0.616627030115838 0.932818273429627 0.333333333333333 20.1 20 1 abnormal redox activity 0.329322214877946 0.616627030115838 0.932818273429627 0.333333333333333 20.1 20 1 increased circulating renin level 0.329322214877946 0.616627030115838 0.932818273429627 0.333333333333333 20.1 20 1 increased circulating glycerol level 0.329322214877946 0.616627030115838 0.932818273429627 0.333333333333333 20.1 20 1 abnormal neutrophil morphology 0.329322214877946 0.616627030115838 0.932818273429627 0.333333333333333 20.1 20 1 abnormal anterior eye segment morphology 0.329322214877946 0.616627030115838 0.932818273429627 0.333333333333333 20.1 20 1 abnormal glycogen homeostasis 0.329322214877946 0.616627030115838 0.932818273429627 0.333333333333333 20.1 20 1 decreased pulmonary respiratory rate 0.329322214877946 0.616627030115838 0.932818273429627 0.333333333333333 20.1 20 1 primary atelectasis 0.329322214877946 0.616627030115838 0.932818273429627 0.333333333333333 20.1 20 1 absent incisors 0.357989768040616 0.652380621246178 0.932818273429627 0.333333333333333 20.1 20 1 macrocytosis 0.357989768040616 0.652380621246178 0.932818273429627 0.333333333333333 20.1 20 1 interdigital webbing 0.357989768040616 0.652380621246178 0.932818273429627 0.333333333333333 20.1 20 1 abnormal prostate gland morphology 0.357989768040616 0.652380621246178 0.932818273429627 0.333333333333333 20.1 20 1 no suckling reflex 0.357989768040616 0.652380621246178 0.932818273429627 0.333333333333333 20.1 20 1 audiogenic seizures 0.357989768040616 0.652380621246178 0.932818273429627 0.333333333333333 20.1 20 1 abnormal seizure response to electrical stimulation 0.357989768040616 0.652380621246178 0.932818273429627 0.333333333333333 20.1 20 1 abnormal apical ectodermal ridge morphology 0.357989768040616 0.652380621246178 0.932818273429627 0.333333333333333 20.1 20 1 increased airway responsiveness 0.357989768040616 0.652380621246178 0.932818273429627 0.333333333333333 20.1 20 1 abnormal cricoid cartilage morphology 0.357989768040616 0.652380621246178 0.932818273429627 0.333333333333333 20.1 20 1 abnormal lymph node B cell domain morphology 0.357989768040616 0.652380621246178 0.932818273429627 0.333333333333333 20.1 20 1 dilated ureter 0.357989768040616 0.652380621246178 0.932818273429627 0.333333333333333 20.1 20 1 abnormal neurotransmitter secretion 0.357989768040616 0.652380621246178 0.932818273429627 0.333333333333333 20.1 20 1 abnormal cerebral aqueduct morphology 0.357989768040616 0.652380621246178 0.932818273429627 0.333333333333333 20.1 20 1 lactation failure 0.357989768040616 0.652380621246178 0.932818273429627 0.333333333333333 20.1 20 1 ostium primum atrial septal defect 0.357989768040616 0.652380621246178 0.932818273429627 0.333333333333333 20.1 20 1 abnormal immune system physiology 0.0567139740978732 0.248597250361495 0.925295545418098 0.330645161290323 20.1 20 1 reduced long term potentiation 0.0682333910995638 0.262590252228645 0.924489538845434 0.330357142857143 20.1 20 1 short femur 0.0999575803023222 0.339811425884232 0.922218065777018 0.329545454545455 20.1 20 1 impaired fertilization 0.135102129269327 0.416150214154784 0.919492298094918 0.328571428571429 20.1 20 1 decreased white adipose tissue amount 0.142304413752072 0.431422582825446 0.91889561263217 0.328358208955224 20.1 20 1 abnormal maternal nurturing 0.15817541028054 0.473797474053114 0.917526170586518 0.327868852459016 20.1 20 1 abnormal NK cell physiology 0.15817541028054 0.473797474053114 0.917526170586518 0.327868852459016 20.1 20 1 abnormal leukocyte migration 0.186400367905879 0.491448464881069 0.914879460479058 0.326923076923077 20.1 20 1 abnormal female meiosis 0.186400367905879 0.491448464881069 0.914879460479058 0.326923076923077 20.1 20 1 abnormal immune system morphology 0.208944032553224 0.531711796395032 0.912539615311592 0.326086956521739 20.1 20 1 abnormal sleep pattern 0.208944032553224 0.531711796395032 0.912539615311592 0.326086956521739 20.1 20 1 increased startle reflex 0.112365441015369 0.377459871067834 0.91185606503795 0.325842696629214 20.1 20 1 abnormal homeostasis 0.221608492323158 0.543011236413147 0.911124825210334 0.325581395348837 20.1 20 1 decreased circulating phosphate level 0.235366344142884 0.543011236413147 0.909497816593887 0.325 20.1 20 1 abnormal female reproductive system morphology 0.235366344142884 0.543011236413147 0.909497816593887 0.325 20.1 20 1 impaired ovarian folliculogenesis 0.235366344142884 0.543011236413147 0.909497816593887 0.325 20.1 20 1 increased susceptibility to weight loss 0.235366344142884 0.543011236413147 0.909497816593887 0.325 20.1 20 1 abnormal long bone metaphysis morphology 0.250375592887917 0.543011236413147 0.90760696874234 0.324324324324324 20.1 20 1 abnormal breathing pattern 0.250375592887917 0.543011236413147 0.90760696874234 0.324324324324324 20.1 20 1 short maxilla 0.266832738176322 0.547123763701174 0.905382441858168 0.323529411764706 20.1 20 1 decreased regulatory T cell number 0.266832738176322 0.547123763701174 0.905382441858168 0.323529411764706 20.1 20 1 decreased cytotoxic T cell cytolysis 0.266832738176322 0.547123763701174 0.905382441858168 0.323529411764706 20.1 20 1 autoimmune response 0.284987067143201 0.547840285563147 0.90272736138351 0.32258064516129 20.1 20 1 decreased double-negative T cell number 0.284987067143201 0.547840285563147 0.90272736138351 0.32258064516129 20.1 20 1 abnormal T cell proliferation 0.284987067143201 0.547840285563147 0.90272736138351 0.32258064516129 20.1 20 1 abnormal stria vascularis morphology 0.305162399240681 0.581456505638601 0.899503335092855 0.321428571428571 20.1 20 1 rib bifurcation 0.305162399240681 0.581456505638601 0.899503335092855 0.321428571428571 20.1 20 1 myoclonus 0.305162399240681 0.581456505638601 0.899503335092855 0.321428571428571 20.1 20 1 abnormal jaw morphology 0.305162399240681 0.581456505638601 0.899503335092855 0.321428571428571 20.1 20 1 abnormal spleen germinal center morphology 0.305162399240681 0.581456505638601 0.899503335092855 0.321428571428571 20.1 20 1 hypoxia 0.305162399240681 0.581456505638601 0.899503335092855 0.321428571428571 20.1 20 1 abnormal inner ear vestibule morphology 0.327791511505103 0.616627030115838 0.895505542492442 0.32 20.1 20 1 abnormal primitive streak morphology 0.327791511505103 0.616627030115838 0.895505542492442 0.32 20.1 20 1 diaphragmatic hernia 0.327791511505103 0.616627030115838 0.895505542492442 0.32 20.1 20 1 increased systemic arterial blood pressure 0.236483908366775 0.543011236413147 0.8931238788156 0.319148936170213 20.1 20 1 abnormal gametogenesis 0.250996861675778 0.543011236413147 0.89041744281919 0.318181818181818 20.1 20 1 decreased macrophage cell number 0.250996861675778 0.543011236413147 0.89041744281919 0.318181818181818 20.1 20 1 abnormal amino acid level 0.250996861675778 0.543011236413147 0.89041744281919 0.318181818181818 20.1 20 1 abnormal basisphenoid bone morphology 0.353473313680094 0.650302411156542 0.89041744281919 0.318181818181818 20.1 20 1 intestinal inflammation 0.353473313680094 0.650302411156542 0.89041744281919 0.318181818181818 20.1 20 1 abnormal tracheal cartilage morphology 0.353473313680094 0.650302411156542 0.89041744281919 0.318181818181818 20.1 20 1 abnormal blood-brain barrier function 0.353473313680094 0.650302411156542 0.89041744281919 0.318181818181818 20.1 20 1 abnormal temporal bone morphology 0.353473313680094 0.650302411156542 0.89041744281919 0.318181818181818 20.1 20 1 decreased susceptibility to viral infection induced morbidity/mortality 0.353473313680094 0.650302411156542 0.89041744281919 0.318181818181818 20.1 20 1 abnormal cerebral cortex pyramidal cell morphology 0.353473313680094 0.650302411156542 0.89041744281919 0.318181818181818 20.1 20 1 skin lesions 0.200060025410211 0.512016000515008 0.888398355647264 0.317460317460317 20.1 20 1 scaly skin 0.266780861613847 0.547123763701174 0.887314943018426 0.317073170731707 20.1 20 1 abnormal response to infection 0.171222178060159 0.473797474053114 0.885586968445848 0.316455696202532 20.1 20 1 impaired righting response 0.14770196177055 0.446969136136549 0.883722574828068 0.315789473684211 20.1 20 1 impaired natural killer cell mediated cytotoxicity 0.223367801103242 0.543011236413147 0.883722574828068 0.315789473684211 20.1 20 1 increased grooming behavior 0.284020258638094 0.547123763701174 0.883722574828068 0.315789473684211 20.1 20 1 abnormal nail morphology 0.383073565837226 0.687853269916751 0.883722574828068 0.315789473684211 20.1 20 1 flaky skin 0.383073565837226 0.687853269916751 0.883722574828068 0.315789473684211 20.1 20 1 abnormal long term depression 0.383073565837226 0.687853269916751 0.883722574828068 0.315789473684211 20.1 20 1 abnormal neurotransmitter level 0.383073565837226 0.687853269916751 0.883722574828068 0.315789473684211 20.1 20 1 abnormal metatarsal bone morphology 0.383073565837226 0.687853269916751 0.883722574828068 0.315789473684211 20.1 20 1 osteoarthritis 0.383073565837226 0.687853269916751 0.883722574828068 0.315789473684211 20.1 20 1 abnormal photoreceptor inner segment morphology 0.383073565837226 0.687853269916751 0.883722574828068 0.315789473684211 20.1 20 1 decreased eye pigmentation 0.383073565837226 0.687853269916751 0.883722574828068 0.315789473684211 20.1 20 1 abnormal humoral immune response 0.140986910174477 0.427688950071965 0.879514372090791 0.314285714285714 20.1 20 1 abnormal nervous system physiology 0.13455684801547 0.416150214154784 0.876038030699128 0.31304347826087 20.1 20 1 abnormal spatial learning 0.0897039113721855 0.320141290585813 0.875590158495294 0.312883435582822 20.1 20 1 abnormal diaphragm morphology 0.32383960769184 0.610728600556067 0.874517131340276 0.3125 20.1 20 1 abnormal bone marrow cell number 0.417915972286596 0.715541114589749 0.874517131340276 0.3125 20.1 20 1 delayed hair appearance 0.417915972286596 0.715541114589749 0.874517131340276 0.3125 20.1 20 1 mixed cellular infiltration to dermis 0.417915972286596 0.715541114589749 0.874517131340276 0.3125 20.1 20 1 white spotting 0.417915972286596 0.715541114589749 0.874517131340276 0.3125 20.1 20 1 abnormal epicardium morphology 0.417915972286596 0.715541114589749 0.874517131340276 0.3125 20.1 20 1 large intestinal inflammation 0.417915972286596 0.715541114589749 0.874517131340276 0.3125 20.1 20 1 abnormal epididymis epithelium morphology 0.417915972286596 0.715541114589749 0.874517131340276 0.3125 20.1 20 1 abnormal wound healing 0.417915972286596 0.715541114589749 0.874517131340276 0.3125 20.1 20 1 abnormal amnion morphology 0.417915972286596 0.715541114589749 0.874517131340276 0.3125 20.1 20 1 decreased circulating prolactin level 0.417915972286596 0.715541114589749 0.874517131340276 0.3125 20.1 20 1 abnormal intestinal lipid absorption 0.417915972286596 0.715541114589749 0.874517131340276 0.3125 20.1 20 1 impaired behavioral response to addictive substance 0.417915972286596 0.715541114589749 0.874517131340276 0.3125 20.1 20 1 decreased skeletal muscle weight 0.417915972286596 0.715541114589749 0.874517131340276 0.3125 20.1 20 1 abnormal urinary bladder physiology 0.417915972286596 0.715541114589749 0.874517131340276 0.3125 20.1 20 1 abnormal social investigation 0.189726013494574 0.491448464881069 0.874517131340275 0.3125 20.1 20 1 abnormal posture 0.189726013494574 0.491448464881069 0.874517131340275 0.3125 20.1 20 1 abnormal kidney physiology 0.26538424701484 0.546929009485845 0.874517131340275 0.3125 20.1 20 1 abnormal phalanx morphology 0.26538424701484 0.546929009485845 0.874517131340275 0.3125 20.1 20 1 polyuria 0.199731896450438 0.512016000515008 0.872245658271859 0.311688311688312 20.1 20 1 increased circulating corticosterone level 0.28173091547341 0.547123763701174 0.870630388534319 0.311111111111111 20.1 20 1 abnormal pancreas morphology 0.299504830174183 0.572650472758094 0.866188396756082 0.30952380952381 20.1 20 1 decreased IgA level 0.278696414359534 0.547123763701174 0.861063021627348 0.307692307692308 20.1 20 1 abnormal Schwann cell morphology 0.373160897953946 0.67804071122019 0.861063021627348 0.307692307692308 20.1 20 1 small seminal vesicle 0.373160897953946 0.67804071122019 0.861063021627348 0.307692307692308 20.1 20 1 increased liver weight 0.207725655341957 0.529152655056956 0.858616819861361 0.306818181818182 20.1 20 1 increased fluid intake 0.295446235831731 0.567726930576618 0.856669842945576 0.306122448979592 20.1 20 1 short radius 0.340192089358595 0.636500806528398 0.855083417310491 0.305555555555556 20.1 20 1 increased hemoglobin content 0.275229961374079 0.547123763701174 0.853765877376269 0.305084745762712 20.1 20 1 abnormal innervation pattern to muscle 0.402754330409919 0.699861262238683 0.851703640957486 0.304347826086957 20.1 20 1 abnormal nasal cavity morphology 0.402754330409919 0.699861262238683 0.851703640957486 0.304347826086957 20.1 20 1 increased susceptibility to age related obesity 0.402754330409919 0.699861262238683 0.851703640957486 0.304347826086957 20.1 20 1 abnormal B cell morphology 0.402754330409919 0.699861262238683 0.851703640957486 0.304347826086957 20.1 20 1 increased osteoblast cell number 0.363666855986015 0.661998759067115 0.848016612208752 0.303030303030303 20.1 20 1 diarrhea 0.363666855986015 0.661998759067115 0.848016612208752 0.303030303030303 20.1 20 1 abnormal middle ear ossicle morphology 0.363666855986015 0.661998759067115 0.848016612208752 0.303030303030303 20.1 20 1 increased susceptibility to pharmacologically induced seizures 0.224615173304747 0.543011236413147 0.8453665602956 0.302083333333333 20.1 20 1 abnormal fibula morphology 0.436819254825984 0.715541114589749 0.839536446086664 0.3 20.1 20 1 decreased skin tensile strength 0.436819254825984 0.715541114589749 0.839536446086664 0.3 20.1 20 1 abnormal male reproductive system physiology 0.436819254825984 0.715541114589749 0.839536446086664 0.3 20.1 20 1 abnormal circulating cytokine level 0.436819254825984 0.715541114589749 0.839536446086664 0.3 20.1 20 1 decreased respiratory quotient 0.326455654294701 0.615428904932223 0.839536446086664 0.3 20.1 20 1 gastrointestinal hemorrhage 0.389730837344916 0.687853269916751 0.839536446086664 0.3 20.1 20 1 delayed eyelid opening 0.389730837344916 0.687853269916751 0.839536446086664 0.3 20.1 20 1 arrested T cell differentiation 0.389730837344916 0.687853269916751 0.839536446086664 0.3 20.1 20 1 abnormal pain threshold 0.389730837344916 0.687853269916751 0.839536446086664 0.3 20.1 20 1 abnormal synaptic transmission 0.389730837344916 0.687853269916751 0.839536446086664 0.3 20.1 20 1 abnormal tibia morphology 0.346280563338235 0.647405412479413 0.83358228689456 0.297872340425532 20.1 20 1 abnormal eye electrophysiology 0.223431607432038 0.543011236413147 0.832598128350411 0.297520661157025 20.1 20 1 increased brown adipose tissue amount 0.378191376326959 0.686429075967391 0.831973054680478 0.297297297297297 20.1 20 1 increased white adipose tissue amount 0.378191376326959 0.686429075967391 0.831973054680478 0.297297297297297 20.1 20 1 abnormal palate morphology 0.418902784745211 0.715541114589749 0.829171798604113 0.296296296296296 20.1 20 1 hypertension 0.3677573172335 0.66895526626569 0.826816196903533 0.295454545454545 20.1 20 1 abnormal photoreceptor outer segment morphology 0.3677573172335 0.66895526626569 0.826816196903533 0.295454545454545 20.1 20 1 abnormal excitatory postsynaptic currents 0.301331942003521 0.575922555308305 0.825185395726209 0.294871794871795 20.1 20 1 abnormal vision 0.404014405073388 0.701805749036349 0.823074947143789 0.294117647058824 20.1 20 1 abnormal urinary bladder morphology 0.476784142412549 0.738711027250835 0.823074947143789 0.294117647058824 20.1 20 1 enlarged sebaceous gland 0.476784142412549 0.738711027250835 0.823074947143789 0.294117647058824 20.1 20 1 abnormal glutamate-mediated receptor currents 0.476784142412549 0.738711027250835 0.823074947143789 0.294117647058824 20.1 20 1 decreased vasoconstriction 0.476784142412549 0.738711027250835 0.823074947143789 0.294117647058824 20.1 20 1 aminoaciduria 0.476784142412549 0.738711027250835 0.823074947143789 0.294117647058824 20.1 20 1 abnormal involuntary movement 0.476784142412549 0.738711027250835 0.823074947143789 0.294117647058824 20.1 20 1 abnormal tarsal bone morphology 0.476784142412549 0.738711027250835 0.823074947143789 0.294117647058824 20.1 20 1 decreased growth hormone level 0.476784142412549 0.738711027250835 0.823074947143789 0.294117647058824 20.1 20 1 pancytopenia 0.476784142412549 0.738711027250835 0.823074947143789 0.294117647058824 20.1 20 1 common atrium 0.476784142412549 0.738711027250835 0.823074947143789 0.294117647058824 20.1 20 1 abnormal excitatory postsynaptic potential 0.310324666933812 0.591066316231132 0.819059947401624 0.292682926829268 20.1 20 1 short ulna 0.391098187180601 0.687853269916751 0.819059947401624 0.292682926829268 20.1 20 1 decreased monocyte cell number 0.341036519259654 0.637840858389765 0.818009870545981 0.292307692307692 20.1 20 1 abnormal lymph node morphology 0.379590811236103 0.687853269916751 0.816215989250924 0.291666666666667 20.1 20 1 abnormal adrenal gland morphology 0.451877495199087 0.715541114589749 0.816215989250924 0.291666666666667 20.1 20 1 apnea 0.451877495199087 0.715541114589749 0.816215989250924 0.291666666666667 20.1 20 1 abnormal impulse conducting system conduction 0.451877495199087 0.715541114589749 0.816215989250924 0.291666666666667 20.1 20 1 hypopigmentation 0.451877495199087 0.715541114589749 0.816215989250924 0.291666666666667 20.1 20 1 increased body temperature 0.451877495199087 0.715541114589749 0.816215989250924 0.291666666666667 20.1 20 1 increased circulating total protein level 0.451877495199087 0.715541114589749 0.816215989250924 0.291666666666667 20.1 20 1 abnormal joint morphology 0.369152698626473 0.671248053971747 0.814095947720402 0.290909090909091 20.1 20 1 abnormal cartilage development 0.402705542948537 0.699861262238683 0.80844250363901 0.288888888888889 20.1 20 1 increased anxiety-related response 0.28399519673808 0.547123763701174 0.805310739651477 0.287769784172662 20.1 20 1 abnormal scapula morphology 0.489615918552985 0.755143307000512 0.799558520082538 0.285714285714286 20.1 20 1 increased acute inflammation 0.489615918552985 0.755143307000512 0.799558520082538 0.285714285714286 20.1 20 1 abnormal stapes morphology 0.489615918552985 0.755143307000512 0.799558520082538 0.285714285714286 20.1 20 1 abnormal bile salt homeostasis 0.489615918552985 0.755143307000512 0.799558520082538 0.285714285714286 20.1 20 1 increased circulating HDL cholesterol level 0.334918607835563 0.626869854771229 0.799558520082537 0.285714285714286 20.1 20 1 abnormal action potential 0.378138752347111 0.686429075967391 0.799558520082537 0.285714285714286 20.1 20 1 abnormal circulating cholesterol level 0.464398938947024 0.722446754615836 0.799558520082537 0.285714285714286 20.1 20 1 decreased circulating progesterone level 0.464398938947024 0.722446754615836 0.799558520082537 0.285714285714286 20.1 20 1 abnormal eye physiology 0.409625920685144 0.711305045517832 0.792895532415183 0.283333333333333 20.1 20 1 abnormal response to injury 0.454919354546395 0.715541114589749 0.789307769825069 0.282051282051282 20.1 20 1 increased dopamine level 0.47513136953741 0.738450035441617 0.787065418206248 0.28125 20.1 20 1 decreased susceptibility to parasitic infection 0.47513136953741 0.738450035441617 0.787065418206248 0.28125 20.1 20 1 abnormal serotonin level 0.47513136953741 0.738450035441617 0.787065418206248 0.28125 20.1 20 1 decreased susceptibility to induced arthritis 0.431814806042068 0.715541114589749 0.785531177624949 0.280701754385965 20.1 20 1 increased liver glycogen level 0.500133155524525 0.759280576360851 0.783567349680887 0.28 20.1 20 1 abnormal male reproductive system morphology 0.46430673775357 0.722446754615836 0.780964135894572 0.27906976744186 20.1 20 1 decreased oxygen consumption 0.46430673775357 0.722446754615836 0.780964135894572 0.27906976744186 20.1 20 1 increased susceptibility to bacterial infection induced morbidity/mortality 0.433876503069938 0.715541114589749 0.777348561191356 0.277777777777778 20.1 20 1 abnormal body wall morphology 0.533500268387396 0.797046196764954 0.777348561191356 0.277777777777778 20.1 20 1 decreased fluid intake 0.533500268387396 0.797046196764954 0.777348561191356 0.277777777777778 20.1 20 1 abnormal microglial cell morphology 0.509091546093663 0.770716079930399 0.771987536631416 0.275862068965517 20.1 20 1 stomach inflammation 0.509091546093663 0.770716079930399 0.771987536631416 0.275862068965517 20.1 20 1 absent long term depression 0.509091546093663 0.770716079930399 0.771987536631416 0.275862068965517 20.1 20 1 abnormal nervous system electrophysiology 0.454227686253509 0.715541114589749 0.766243581745765 0.273809523809524 20.1 20 1 abnormal T cell subpopulation ratio 0.516930562119184 0.774617333296066 0.763214950987877 0.272727272727273 20.1 20 1 head tossing 0.516930562119184 0.774617333296066 0.763214950987877 0.272727272727273 20.1 20 1 decreased sensitivity to xenobiotic induced morbidity/mortality 0.516930562119184 0.774617333296066 0.763214950987877 0.272727272727273 20.1 20 1 testis hypoplasia 0.540669395380318 0.806545799705273 0.763214950987877 0.272727272727273 20.1 20 1 abnormal cochlear sensory epithelium morphology 0.540669395380318 0.806545799705273 0.763214950987877 0.272727272727273 20.1 20 1 impaired humoral immune response 0.540669395380318 0.806545799705273 0.763214950987877 0.272727272727273 20.1 20 1 impaired skeletal muscle contractility 0.523927169591907 0.784694392806133 0.756339140618617 0.27027027027027 20.1 20 1 abnormal stomach morphology 0.546912408313685 0.815125593577167 0.75343014392393 0.269230769230769 20.1 20 1 abnormal erythrocyte osmotic lysis 0.546912408313685 0.815125593577167 0.75343014392393 0.269230769230769 20.1 20 1 decreased anxiety-related response 0.483887454720855 0.749483215204313 0.750804951784822 0.268292682926829 20.1 20 1 increased susceptibility to parasitic infection 0.510970940761726 0.770716079930399 0.746254618743702 0.266666666666667 20.1 20 1 abnormal autopod morphology 0.536079034994073 0.800418126979445 0.746254618743702 0.266666666666667 20.1 20 1 lethality at weaning, complete penetrance 0.536079034994073 0.800418126979445 0.746254618743702 0.266666666666667 20.1 20 1 abnormal estrous cycle 0.552495440184116 0.822953537399993 0.746254618743702 0.266666666666667 20.1 20 1 enhanced paired-pulse facilitation 0.552495440184116 0.822953537399993 0.746254618743702 0.266666666666667 20.1 20 1 increased circulating LDL cholesterol level 0.541458672713011 0.807481084156843 0.742447197219499 0.26530612244898 20.1 20 1 increased susceptibility to weight gain 0.55758037865567 0.829782346339204 0.74076745242941 0.264705882352941 20.1 20 1 increased susceptibility to viral infection induced morbidity/mortality 0.55758037865567 0.829782346339204 0.74076745242941 0.264705882352941 20.1 20 1 stereotypic behavior 0.587224090726744 0.831886341118254 0.73643547902339 0.263157894736842 20.1 20 1 altered susceptibility to infection 0.587224090726744 0.831886341118254 0.73643547902339 0.263157894736842 20.1 20 1 abnormal reproductive system physiology 0.562273520432859 0.831886341118254 0.73643547902339 0.263157894736842 20.1 20 1 delayed sexual maturation 0.587224090726744 0.831886341118254 0.73643547902339 0.263157894736842 20.1 20 1 abnormal ear morphology 0.587224090726744 0.831886341118254 0.73643547902339 0.263157894736842 20.1 20 1 abnormal optic vesicle formation 0.587224090726744 0.831886341118254 0.73643547902339 0.263157894736842 20.1 20 1 abnormal cochlear inner hair cell morphology 0.587224090726744 0.831886341118254 0.73643547902339 0.263157894736842 20.1 20 1 increased circulating VLDL cholesterol level 0.587224090726744 0.831886341118254 0.73643547902339 0.263157894736842 20.1 20 1 hyporesponsive to tactile stimuli 0.562273520432859 0.831886341118254 0.73643547902339 0.263157894736842 20.1 20 1 increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 0.587224090726744 0.831886341118254 0.73643547902339 0.263157894736842 20.1 20 1 right-sided stomach 0.587224090726744 0.831886341118254 0.73643547902339 0.263157894736842 20.1 20 1 decreased inflammatory response 0.552902573334808 0.82331346972184 0.732928643408993 0.261904761904762 20.1 20 1 abnormal crista ampullaris morphology 0.589345300663989 0.831886341118254 0.730031692249273 0.260869565217391 20.1 20 1 increased susceptibility to fungal infection 0.589345300663989 0.831886341118254 0.730031692249273 0.260869565217391 20.1 20 1 abnormal digestive system physiology 0.574646338630969 0.831886341118254 0.727598253275109 0.26 20.1 20 1 abnormal cochlea morphology 0.578340105196754 0.831886341118254 0.725525323778599 0.259259259259259 20.1 20 1 cryptorchism 0.591715776562651 0.831886341118254 0.725525323778599 0.259259259259259 20.1 20 1 decreased susceptibility to pharmacologically induced seizures 0.591715776562651 0.831886341118254 0.725525323778599 0.259259259259259 20.1 20 1 abnormal CD8-positive, alpha beta T cell morphology 0.594204963198298 0.831886341118254 0.722181889106808 0.258064516129032 20.1 20 1 abnormal intestinal mucosa morphology 0.601828777410542 0.834010631648313 0.715883791236691 0.255813953488372 20.1 20 1 increased circulating luteinizing hormone level 0.634154722434527 0.877585464287002 0.69961370507222 0.25 20.1 20 1 abnormal reflex 0.634144846353652 0.877585464287002 0.69961370507222 0.25 20.1 20 1 abnormal limb bone morphology 0.634144846353652 0.877585464287002 0.69961370507222 0.25 20.1 20 1 abnormal retinal inner nuclear layer morphology 0.634154722434527 0.877585464287002 0.69961370507222 0.25 20.1 20 1 enhanced coordination 0.634154722434527 0.877585464287002 0.69961370507222 0.25 20.1 20 1 perinatal lethality 0.634746663644528 0.87816035918563 0.69961370507222 0.25 20.1 20 1 small lymph nodes 0.635167902485624 0.878254673392434 0.69961370507222 0.25 20.1 20 1 decreased ovulation rate 0.635167902485624 0.878254673392434 0.69961370507222 0.25 20.1 20 1 increased urine glucose level 0.637359036026997 0.880305720220519 0.69961370507222 0.25 20.1 20 1 brain inflammation 0.637359036026997 0.880305720220519 0.69961370507222 0.25 20.1 20 1 enhanced behavioral response to xenobiotic 0.637359036026997 0.880305720220519 0.69961370507222 0.25 20.1 20 1 decreased muscle cell glucose uptake 0.637359036026997 0.880305720220519 0.69961370507222 0.25 20.1 20 1 abnormal nest building behavior 0.67781045415755 0.920586134161564 0.671629156869331 0.24 20.1 20 1 abnormal feces composition 0.67781045415755 0.920586134161564 0.671629156869331 0.24 20.1 20 1 abnormal vertebrae development 0.67781045415755 0.920586134161564 0.671629156869331 0.24 20.1 20 1 abnormal anxiety-related response 0.683528760237626 0.925944567932622 0.666298766735448 0.238095238095238 20.1 20 1 dry skin 0.683528760237626 0.925944567932622 0.666298766735448 0.238095238095238 20.1 20 1 decreased vocalization 0.683528760237626 0.925944567932622 0.666298766735448 0.238095238095238 20.1 20 1 abnormal bone remodeling 0.706323544784784 0.925944567932622 0.658459957715031 0.235294117647059 20.1 20 1 decreased pancreatic beta cell number 0.706323544784784 0.925944567932622 0.658459957715031 0.235294117647059 20.1 20 1 abnormal inhibitory postsynaptic currents 0.741909587503016 0.964463077561407 0.658459957715031 0.235294117647059 20.1 20 1 abnormal tectorial membrane morphology 0.717079867910709 0.939797772090563 0.645797266220511 0.230769230769231 20.1 20 1 abnormal crypts of Lieberkuhn morphology 0.776045800893713 0.99829354074339 0.612161991938193 0.21875 20.1 20 1 abnormal retinal cone cell morphology 0.76337980933027 0.989529586091218 0.608359743541061 0.217391304347826 20.1 20 1 hypotension 0.76337980933027 0.989529586091218 0.608359743541061 0.217391304347826 20.1 20 1 abnormal lens development 0.76337980933027 0.989529586091218 0.608359743541061 0.217391304347826 20.1 20 1 abnormal sensory capabilities/reflexes/nociception 0.797119784815704 1 0.583011420893517 0.208333333333333 20.1 20 1 decreased retinal photoreceptor cell number 0.814326726215344 1 0.578990652473562 0.206896551724138 20.1 20 1 increased susceptibility to induced arthritis 0.814326726215344 1 0.578990652473562 0.206896551724138 20.1 20 1 impaired behavioral response to xenobiotic 0.852333970748389 1 0.559690964057776 0.2 20.1 20 1 abnormal energy expenditure 0.826947117480242 1 0.559690964057776 0.2 20.1 20 1 impaired conditioned place preference behavior 0.826947117480242 1 0.559690964057776 0.2 20.1 20 1 abnormal stomach mucosa morphology 0.826947117480242 1 0.559690964057776 0.2 20.1 20 1 abnormal body temperature homeostasis 0.863035805960808 1 0.541636416830106 0.193548387096774 20.1 20 1 arrested B cell differentiation 0.942097347042737 1 0.477784969317614 0.170731707317073 20.1 20 1 increased oligodendrocyte number 1.18515999426361e-05 0.000545941756616802 4.05347832563682 1 21.1 21 1 abnormal visual evoked potential 7.84098805179671e-05 0.00250950870093472 3.54679353493222 0.875 21.1 21 1 abnormal umbilical vein topology 7.84098805179671e-05 0.00250950870093472 3.54679353493222 0.875 21.1 21 1 heart hemorrhage 0.000348433857624685 0.00856113875490634 3.47440999340299 0.857142857142857 21.1 21 1 abnormal cerebellum white matter morphology 0.000348433857624685 0.00856113875490634 3.47440999340299 0.857142857142857 21.1 21 1 absent ectoplacental cone 0.00151868727335795 0.027322210450975 3.37789860469735 0.833333333333333 21.1 21 1 ectopic hippocampus pyramidal cells 0.00151868727335795 0.027322210450975 3.37789860469735 0.833333333333333 21.1 21 1 abnormal intestinal enteroendocrine cell morphology 0.00151868727335795 0.027322210450975 3.37789860469735 0.833333333333333 21.1 21 1 decreased retinal apoptosis 0.00151868727335795 0.027322210450975 3.37789860469735 0.833333333333333 21.1 21 1 abnormal hippocampus neuron morphology 7.16837478074846e-05 0.00236176586319362 3.24278266050946 0.8 21.1 21 1 symmetric azygos veins 0.0002920023813382 0.00776851255164462 3.1527053643842 0.777777777777778 21.1 21 1 colon polyps 0.00115850578894484 0.0223033744539917 3.04010874422762 0.75 21.1 21 1 abnormal extraembryonic tissue physiology 0.00115850578894484 0.0223033744539917 3.04010874422762 0.75 21.1 21 1 decreased hippocampus pyramidal cell number 0.00115850578894484 0.0223033744539917 3.04010874422762 0.75 21.1 21 1 broad head 0.00444432081269111 0.06228308744546 2.89534166116916 0.714285714285714 21.1 21 1 polyphalangy 0.00444432081269111 0.06228308744546 2.89534166116916 0.714285714285714 21.1 21 1 skin photosensitivity 0.00444432081269111 0.06228308744546 2.89534166116916 0.714285714285714 21.1 21 1 retina hyperplasia 0.00444432081269111 0.06228308744546 2.89534166116916 0.714285714285714 21.1 21 1 abnormal organ of Corti supporting cell morphology 0.00444432081269111 0.06228308744546 2.89534166116916 0.714285714285714 21.1 21 1 decreased brain cholesterol level 0.00444432081269111 0.06228308744546 2.89534166116916 0.714285714285714 21.1 21 1 long stride length 0.00444432081269111 0.06228308744546 2.89534166116916 0.714285714285714 21.1 21 1 embryonic lethality at implantation, incomplete penetrance 0.00444432081269111 0.06228308744546 2.89534166116916 0.714285714285714 21.1 21 1 dysmyelination 0.00444432081269111 0.06228308744546 2.89534166116916 0.714285714285714 21.1 21 1 darkened coat color 1.99235254475821e-05 0.000850861924306909 2.70231888375788 0.666666666666667 21.1 21 1 heterochrony 0.000102564299852287 0.00311132555954345 2.70231888375788 0.666666666666667 21.1 21 1 abnormal superior cervical ganglion morphology 0.000537288770701701 0.0122394050141494 2.70231888375788 0.666666666666667 21.1 21 1 increased osteosarcoma incidence 0.000537288770701701 0.0122394050141494 2.70231888375788 0.666666666666667 21.1 21 1 decreased fear-related response 0.00289151260415811 0.045667540335513 2.70231888375788 0.666666666666667 21.1 21 1 eye opacity 0.00289151260415811 0.045667540335513 2.70231888375788 0.666666666666667 21.1 21 1 abnormal hippocampus granule cell morphology 0.00289151260415811 0.045667540335513 2.70231888375788 0.666666666666667 21.1 21 1 abnormal cerebellar layer morphology 0.00289151260415811 0.045667540335513 2.70231888375788 0.666666666666667 21.1 21 1 axonal spheroids 0.00289151260415811 0.045667540335513 2.70231888375788 0.666666666666667 21.1 21 1 cerebellum atrophy 0.00289151260415811 0.045667540335513 2.70231888375788 0.666666666666667 21.1 21 1 increased brain size 6.78760797773031e-05 0.0022663321939066 2.62283891658853 0.647058823529412 21.1 21 1 enlarged pituitary gland 0.00992067918560157 0.103906060943932 2.53342395352302 0.625 21.1 21 1 dermal cysts 0.00992067918560157 0.103906060943932 2.53342395352302 0.625 21.1 21 1 unidirectional circling 0.00992067918560157 0.103906060943932 2.53342395352302 0.625 21.1 21 1 decreased susceptibility to age related obesity 0.00992067918560157 0.103906060943932 2.53342395352302 0.625 21.1 21 1 elevated level of mitotic sister chromatid exchange 0.00992067918560157 0.103906060943932 2.53342395352302 0.625 21.1 21 1 choroidal neovascularization 0.00992067918560157 0.103906060943932 2.53342395352302 0.625 21.1 21 1 abnormal meiotic spindle morphology 0.00992067918560157 0.103906060943932 2.53342395352302 0.625 21.1 21 1 abnormal mitotic spindle assembly checkpoint 0.00992067918560157 0.103906060943932 2.53342395352302 0.625 21.1 21 1 pleural effusion 0.00992067918560157 0.103906060943932 2.53342395352302 0.625 21.1 21 1 abnormal bronchus epithelium morphology 0.00992067918560157 0.103906060943932 2.53342395352302 0.625 21.1 21 1 abnormal heart echocardiography feature 0.00992067918560157 0.103906060943932 2.53342395352302 0.625 21.1 21 1 increased brain apoptosis 0.00992067918560157 0.103906060943932 2.53342395352302 0.625 21.1 21 1 abnormal retinal inner plexiform layer morphology 0.00115419066739205 0.0223033744539917 2.49444820039189 0.615384615384615 21.1 21 1 absent ductus venosus valve 9.07426388950789e-05 0.00283927439310074 2.43208699538209 0.6 21.1 21 1 impaired basement membrane formation 0.00601966272103047 0.0768600073129678 2.43208699538209 0.6 21.1 21 1 increased atrioventricular cushion size 0.00601966272103047 0.0768600073129678 2.43208699538209 0.6 21.1 21 1 osteosclerosis 0.00601966272103047 0.0768600073129678 2.43208699538209 0.6 21.1 21 1 abnormal spinal cord dorsal column morphology 0.00601966272103047 0.0768600073129678 2.43208699538209 0.6 21.1 21 1 increased serotonin level 0.00601966272103047 0.0768600073129678 2.43208699538209 0.6 21.1 21 1 thick aortic valve cusps 0.00601966272103047 0.0768600073129678 2.43208699538209 0.6 21.1 21 1 abnormal glial cell morphology 0.000720993653338965 0.0153288180570998 2.43208699538209 0.6 21.1 21 1 increased brain weight 7.47373545310224e-06 0.000371818338791836 2.40206123000701 0.592592592592593 21.1 21 1 abnormal germ layer development 5.72770598285402e-05 0.00200671389188019 2.39523719242176 0.590909090909091 21.1 21 1 abnormal rostral-caudal body axis extension 0.0036569394000729 0.0542484962371125 2.36452902328815 0.583333333333333 21.1 21 1 abnormal object recognition memory 3.00411143888459e-06 0.000160703810843557 2.35363257617622 0.580645161290323 21.1 21 1 Leydig cell hypoplasia 0.000279263357443226 0.00746954410365619 2.34675060957921 0.578947368421053 21.1 21 1 liver hypoplasia 1.92619312128546e-09 2.45713096881927e-07 2.3385451878674 0.576923076923077 21.1 21 1 abnormal Schwann cell morphology 2.26652221922701e-05 0.000939662336721198 2.3385451878674 0.576923076923077 21.1 21 1 abnormal embryonic/fetal subventricular zone morphology 0.0001735559323583 0.00479689313045858 2.31627332893533 0.571428571428571 21.1 21 1 midline facial cleft 0.00222653016891884 0.0374222553728758 2.31627332893533 0.571428571428571 21.1 21 1 increased hemangioma incidence 0.00222653016891884 0.0374222553728758 2.31627332893533 0.571428571428571 21.1 21 1 amyloid beta deposits 0.00222653016891884 0.0374222553728758 2.31627332893533 0.571428571428571 21.1 21 1 increased pulmonary respiratory rate 0.00222653016891884 0.0374222553728758 2.31627332893533 0.571428571428571 21.1 21 1 testis degeneration 0.00222653016891884 0.0374222553728758 2.31627332893533 0.571428571428571 21.1 21 1 abnormal microglial cell physiology 8.92374734117874e-06 0.000431025660411303 2.2969710511942 0.566666666666667 21.1 21 1 dilated heart 0.000107840637039567 0.003231970899228 2.29109644492516 0.565217391304348 21.1 21 1 increased adipocyte glucose uptake 0.00083133151691718 0.0169717815486572 2.25193240313157 0.555555555555556 21.1 21 1 abnormal sympathetic neuron morphology 0.0187071374124059 0.163578702644703 2.25193240313157 0.555555555555556 21.1 21 1 increased pheochromocytoma incidence 0.0187071374124059 0.163578702644703 2.25193240313157 0.555555555555556 21.1 21 1 abnormal NMDA-mediated synaptic currents 0.0187071374124059 0.163578702644703 2.25193240313157 0.555555555555556 21.1 21 1 pancreas cysts 0.0187071374124059 0.163578702644703 2.25193240313157 0.555555555555556 21.1 21 1 premature neuronal precursor differentiation 0.0187071374124059 0.163578702644703 2.25193240313157 0.555555555555556 21.1 21 1 decreased effector memory CD4-positive, alpha-beta T cell number 0.0187071374124059 0.163578702644703 2.25193240313157 0.555555555555556 21.1 21 1 abnormal ureteric bud invasion 0.0187071374124059 0.163578702644703 2.25193240313157 0.555555555555556 21.1 21 1 abnormal coronary sinus connection 0.0187071374124059 0.163578702644703 2.25193240313157 0.555555555555556 21.1 21 1 abnormal circulating enzyme level 0.000509677569002073 0.011839025144502 2.22941307910025 0.55 21.1 21 1 increased mammary adenocarcinoma incidence 0.000509677569002073 0.011839025144502 2.22941307910025 0.55 21.1 21 1 increased adenoma incidence 0.000313090579394015 0.00815510802348285 2.21098817762009 0.545454545454545 21.1 21 1 delayed hepatic development 0.0110386861467394 0.110720692701671 2.21098817762009 0.545454545454545 21.1 21 1 abnormal hemoglobin 0.0110386861467394 0.110720692701671 2.21098817762009 0.545454545454545 21.1 21 1 fatigue 0.0110386861467394 0.110720692701671 2.21098817762009 0.545454545454545 21.1 21 1 loss of cortex neurons 0.0110386861467394 0.110720692701671 2.21098817762009 0.545454545454545 21.1 21 1 abnormal spinal cord ventral horn morphology 0.0110386861467394 0.110720692701671 2.21098817762009 0.545454545454545 21.1 21 1 reduced sympathetic cervical ganglion size 0.0110386861467394 0.110720692701671 2.21098817762009 0.545454545454545 21.1 21 1 ventricular hypoplasia 0.000118754380552532 0.00349587599555531 2.18264217534291 0.538461538461538 21.1 21 1 abnormal tail bud morphology 0.00657681292153388 0.0796098401085913 2.18264217534291 0.538461538461538 21.1 21 1 axonal dystrophy 0.00657681292153388 0.0796098401085913 2.18264217534291 0.538461538461538 21.1 21 1 abnormal cell differentiation 1.51065059659524e-06 9.16522770495281e-05 2.17503715034171 0.536585365853659 21.1 21 1 delayed intramembranous bone ossification 0.00394714332958155 0.0575635869520562 2.16185510700631 0.533333333333333 21.1 21 1 decreased thymocyte apoptosis 0.00394714332958155 0.0575635869520562 2.16185510700631 0.533333333333333 21.1 21 1 left pulmonary isomerism 0.00087941136931022 0.0175384548814997 2.12325055152405 0.523809523809524 21.1 21 1 embryonic lethality at implantation, complete penetrance 0.00087941136931022 0.0175384548814997 2.12325055152405 0.523809523809524 21.1 21 1 abnormal myelin sheath morphology 9.98297664310829e-07 6.36734728198253e-05 2.114858256854 0.521739130434783 21.1 21 1 increased cellular sensitivity to ionizing radiation 0.000328796896369815 0.0083019792060595 2.10780872933115 0.52 21.1 21 1 increased mortality induced by gamma-irradiation 0.00012408647508624 0.00359032655715653 2.09662672015698 0.517241379310345 21.1 21 1 pericardial edema 2.37785995916458e-08 2.31957907781251e-06 2.02673916281841 0.5 21.1 21 1 abnormal embryonic hematopoiesis 0.000124849546610669 0.00359032655715653 2.02673916281841 0.5 21.1 21 1 abnormal auditory brainstem response waveform shape 0.000124849546610669 0.00359032655715653 2.02673916281841 0.5 21.1 21 1 abnormal optic cup morphology 0.000202869561972603 0.0055151697858672 2.02673916281841 0.5 21.1 21 1 small superior cervical ganglion 0.000330269029096866 0.0083019792060595 2.02673916281841 0.5 21.1 21 1 subcutaneous edema 0.000330269029096866 0.0083019792060595 2.02673916281841 0.5 21.1 21 1 abnormal nasal bone morphology 0.000538839412187096 0.0122394050141494 2.02673916281841 0.5 21.1 21 1 ocular hypertelorism 0.000881329391030137 0.0175384548814997 2.02673916281841 0.5 21.1 21 1 intracerebral hemorrhage 0.00144573215922643 0.0266389536746352 2.02673916281841 0.5 21.1 21 1 testis hypoplasia 0.00144573215922643 0.0266389536746352 2.02673916281841 0.5 21.1 21 1 spleen atrophy 0.00237980359699663 0.0398637134513745 2.02673916281841 0.5 21.1 21 1 increased gastrointestinal tumor incidence 0.00393369544808992 0.0575635869520562 2.02673916281841 0.5 21.1 21 1 blepharitis 0.00653536992996799 0.0796098401085913 2.02673916281841 0.5 21.1 21 1 dystonia 0.00653536992996799 0.0796098401085913 2.02673916281841 0.5 21.1 21 1 abnormal placing response 0.0109270956741489 0.110720692701671 2.02673916281841 0.5 21.1 21 1 absent olfactory bulb 0.0109270956741489 0.110720692701671 2.02673916281841 0.5 21.1 21 1 skeletal muscle necrosis 0.0109270956741489 0.110720692701671 2.02673916281841 0.5 21.1 21 1 abnormal viscerocranium morphology 0.0109270956741489 0.110720692701671 2.02673916281841 0.5 21.1 21 1 increased stomach tumor incidence 0.0109270956741489 0.110720692701671 2.02673916281841 0.5 21.1 21 1 multiple persisting craniopharyngeal ducts 0.0109270956741489 0.110720692701671 2.02673916281841 0.5 21.1 21 1 interstitial pneumonia 0.0184204328934059 0.163578702644703 2.02673916281841 0.5 21.1 21 1 abnormal corticospinal tract morphology 0.0184204328934059 0.163578702644703 2.02673916281841 0.5 21.1 21 1 loss of dopaminergic neurons 0.0184204328934059 0.163578702644703 2.02673916281841 0.5 21.1 21 1 reduced cerebellar foliation 0.0184204328934059 0.163578702644703 2.02673916281841 0.5 21.1 21 1 decreased red blood cell distribution width 0.0184204328934059 0.163578702644703 2.02673916281841 0.5 21.1 21 1 prenatal growth retardation 0.0184204328934059 0.163578702644703 2.02673916281841 0.5 21.1 21 1 abnormal vitelline vein connection 0.0184204328934059 0.163578702644703 2.02673916281841 0.5 21.1 21 1 increased cranium width 0.0313946121037814 0.235413228674665 2.02673916281841 0.5 21.1 21 1 abnormal optic nerve innervation 0.0313946121037814 0.235413228674665 2.02673916281841 0.5 21.1 21 1 absent trophoblast giant cells 0.0313946121037814 0.235413228674665 2.02673916281841 0.5 21.1 21 1 abnormal neuron specification 0.0313946121037814 0.235413228674665 2.02673916281841 0.5 21.1 21 1 abnormal reproductive system development 0.0313946121037814 0.235413228674665 2.02673916281841 0.5 21.1 21 1 abnormal inferior vena cava valve morphology 0.0313946121037814 0.235413228674665 2.02673916281841 0.5 21.1 21 1 thin ventricle myocardium compact layer 0.0313946121037814 0.235413228674665 2.02673916281841 0.5 21.1 21 1 decreased circulating lactate level 0.0313946121037814 0.235413228674665 2.02673916281841 0.5 21.1 21 1 abnormal embryo turning 1.0331289640204e-06 6.50609695696392e-05 1.98988935985808 0.490909090909091 21.1 21 1 embryonic lethality between somite formation and embryo turning, complete penetrance 5.97999402302528e-08 5.2193807481668e-06 1.96883232959503 0.485714285714286 21.1 21 1 abnormal postnatal growth/weight/body size 0.000321396338335758 0.0083019792060595 1.96136048014685 0.483870967741935 21.1 21 1 increased neuron apoptosis 8.92922373814512e-09 9.4516783185685e-07 1.95167474938069 0.481481481481481 21.1 21 1 abnormal atrioventricular cushion morphology 0.000851818570197178 0.0171570744402063 1.95167474938069 0.481481481481481 21.1 21 1 abnormal nervous system morphology 1.42602344182359e-08 1.44785033123925e-06 1.94977438448354 0.481012658227848 21.1 21 1 short stride length 6.70167244868987e-06 0.000336775963961941 1.94566959630568 0.48 21.1 21 1 failure to gastrulate 1.73274292787247e-05 0.000756175093523294 1.93862006878283 0.478260869565217 21.1 21 1 double outlet right ventricle 7.88896163310112e-11 1.18932073105085e-08 1.93203172530353 0.476635514018692 21.1 21 1 small liver 3.5082707538217e-08 3.23215685190055e-06 1.92280382113542 0.474358974358974 21.1 21 1 unresponsive to tactile stimuli 0.00617375482667143 0.0777580512979503 1.92006868056481 0.473684210526316 21.1 21 1 increased malignant tumor incidence 0.00617375482667143 0.0777580512979503 1.92006868056481 0.473684210526316 21.1 21 1 increased liver cholesterol level 0.00617375482667143 0.0777580512979503 1.92006868056481 0.473684210526316 21.1 21 1 embryonic lethality between implantation and somite formation, incomplete penetrance 0.00617375482667143 0.0777580512979503 1.92006868056481 0.473684210526316 21.1 21 1 pale liver 8.9371206580085e-08 7.28888119239218e-06 1.91718569455796 0.472972972972973 21.1 21 1 abnormal lysosome morphology 0.000188890099720005 0.00519186876302224 1.91414254266183 0.472222222222222 21.1 21 1 enlarged liver sinusoidal spaces 0.000305524565202979 0.00804580144851024 1.90751921206439 0.470588235294118 21.1 21 1 decreased growth hormone level 0.0102267978832697 0.105776131952738 1.90751921206439 0.470588235294118 21.1 21 1 increased hepatoma incidence 0.0102267978832697 0.105776131952738 1.90751921206439 0.470588235294118 21.1 21 1 decreased body fat mass 0.0102267978832697 0.105776131952738 1.90751921206439 0.470588235294118 21.1 21 1 abnormal dendritic spine morphology 1.02883238293304e-05 0.000487470581437321 1.90751921206439 0.470588235294118 21.1 21 1 lethality throughout fetal growth and development, incomplete penetrance 2.28008059240006e-16 9.45283412265859e-14 1.9021909461089 0.46927374301676 21.1 21 1 bradykinesia 0.000494819978093188 0.0116119310896868 1.90006796514226 0.46875 21.1 21 1 increased fibroblast apoptosis 0.000494819978093188 0.0116119310896868 1.90006796514226 0.46875 21.1 21 1 small placenta 4.25719239228466e-05 0.00155731854056001 1.89162321863052 0.466666666666667 21.1 21 1 abnormal synaptic transmission 0.000802563032349193 0.0165674318918557 1.89162321863052 0.466666666666667 21.1 21 1 absent egg cylinders 0.0170345539756453 0.154085283688792 1.89162321863052 0.466666666666667 21.1 21 1 abnormal placenta size 0.0170345539756453 0.154085283688792 1.89162321863052 0.466666666666667 21.1 21 1 abnormal olfactory nerve morphology 0.0170345539756453 0.154085283688792 1.89162321863052 0.466666666666667 21.1 21 1 abnormal energy homeostasis 0.0170345539756453 0.154085283688792 1.89162321863052 0.466666666666667 21.1 21 1 abnormal cerebral aqueduct morphology 0.0170345539756453 0.154085283688792 1.89162321863052 0.466666666666667 21.1 21 1 abnormal embryonic neuroepithelium morphology 3.79309752903677e-06 0.00020075170432934 1.88696404814128 0.46551724137931 21.1 21 1 abnormal vasculogenesis 6.84257734220855e-05 0.00226945481849917 1.88533875611015 0.465116279069767 21.1 21 1 lymphoid hyperplasia 0.00130382817248412 0.024570246811017 1.88197207975995 0.464285714285714 21.1 21 1 ventricular septal defect 2.44595056324777e-12 4.68023232775294e-10 1.87771422437588 0.463235294117647 21.1 21 1 axon degeneration 9.70517214258279e-06 0.000464261840474513 1.87661033594297 0.462962962962963 21.1 21 1 abnormal Mullerian duct morphology 0.0021220907923133 0.036657644763051 1.87083615029392 0.461538461538462 21.1 21 1 absent common myeloid progenitor cells 0.0285721071550106 0.220917176697439 1.87083615029392 0.461538461538462 21.1 21 1 increased foot pad pigmentation 0.0285721071550106 0.220917176697439 1.87083615029392 0.461538461538462 21.1 21 1 increased pituitary adenoma incidence 0.0285721071550106 0.220917176697439 1.87083615029392 0.461538461538462 21.1 21 1 increased synaptic depression 0.0285721071550106 0.220917176697439 1.87083615029392 0.461538461538462 21.1 21 1 abnormal bile duct development 0.0285721071550106 0.220917176697439 1.87083615029392 0.461538461538462 21.1 21 1 orthokeratosis 0.0285721071550106 0.220917176697439 1.87083615029392 0.461538461538462 21.1 21 1 empty decidua capsularis 0.0285721071550106 0.220917176697439 1.87083615029392 0.461538461538462 21.1 21 1 decreased cardiac stroke volume 0.0285721071550106 0.220917176697439 1.87083615029392 0.461538461538462 21.1 21 1 abnormal retinal ganglion layer morphology 0.00346115881999302 0.0522920450473693 1.85784423258354 0.458333333333333 21.1 21 1 abnormal allantois morphology 6.3777299423909e-05 0.00218822113540653 1.85050097474725 0.456521739130435 21.1 21 1 muscular atrophy 0.000102204451821023 0.00311132555954345 1.84249014801674 0.454545454545455 21.1 21 1 dextrocardia 0.000742198315009856 0.0156459178693815 1.84249014801674 0.454545454545455 21.1 21 1 decreased brown adipose tissue amount 0.000742198315009856 0.0156459178693815 1.84249014801674 0.454545454545455 21.1 21 1 abnormal chorion morphology 0.0056588501746158 0.0746758080071979 1.84249014801674 0.454545454545455 21.1 21 1 increased myocardial infarction size 0.0056588501746158 0.0746758080071979 1.84249014801674 0.454545454545455 21.1 21 1 increased mammary gland tumor incidence 0.0056588501746158 0.0746758080071979 1.84249014801674 0.454545454545455 21.1 21 1 embryonic lethality before implantation, incomplete penetrance 0.0056588501746158 0.0746758080071979 1.84249014801674 0.454545454545455 21.1 21 1 abnormal enteric ganglia morphology 0.0483578837346496 0.294969584317246 1.84249014801674 0.454545454545455 21.1 21 1 abnormal glossopharyngeal ganglion morphology 0.0483578837346496 0.294969584317246 1.84249014801674 0.454545454545455 21.1 21 1 abnormal proximal-distal axis patterning 0.0483578837346496 0.294969584317246 1.84249014801674 0.454545454545455 21.1 21 1 retinal detachment 0.0483578837346496 0.294969584317246 1.84249014801674 0.454545454545455 21.1 21 1 pathological neovascularization 0.0483578837346496 0.294969584317246 1.84249014801674 0.454545454545455 21.1 21 1 increased motor neuron number 0.0483578837346496 0.294969584317246 1.84249014801674 0.454545454545455 21.1 21 1 abnormal Bruch membrane morphology 0.0483578837346496 0.294969584317246 1.84249014801674 0.454545454545455 21.1 21 1 abnormal palate development 0.0483578837346496 0.294969584317246 1.84249014801674 0.454545454545455 21.1 21 1 palatal shelf hypoplasia 0.0483578837346496 0.294969584317246 1.84249014801674 0.454545454545455 21.1 21 1 aorta dilation 0.0483578837346496 0.294969584317246 1.84249014801674 0.454545454545455 21.1 21 1 common atrioventricular valve 0.0483578837346496 0.294969584317246 1.84249014801674 0.454545454545455 21.1 21 1 abnormal extraembryonic ectoderm morphology 0.0483578837346496 0.294969584317246 1.84249014801674 0.454545454545455 21.1 21 1 embryonic lethality, complete penetrance 2.00161484956308e-25 1.65967231276272e-22 1.84249014801674 0.454545454545455 21.1 21 1 abnormal motor coordination/ balance 6.55012437223878e-09 7.08410190258433e-07 1.84249014801674 0.454545454545455 21.1 21 1 lethality throughout fetal growth and development, complete penetrance 1.50156859562382e-15 5.09532030468972e-13 1.83473229476193 0.452631578947368 21.1 21 1 failure of chorioallantoic fusion 3.6833679838822e-05 0.00138823906968287 1.82803924489504 0.450980392156863 21.1 21 1 abnormal neuron proliferation 0.00927789674185994 0.101001173502742 1.82406524653657 0.45 21.1 21 1 absent mesoderm 8.38273425732655e-06 0.000408863754217643 1.82406524653657 0.45 21.1 21 1 abnormal muscle physiology 6.52631164647027e-08 5.59800007606717e-06 1.82178801152217 0.449438202247191 21.1 21 1 abnormal microglial cell morphology 0.0019384898730282 0.0336027425725272 1.81707649080271 0.448275862068966 21.1 21 1 decreased neuron apoptosis 0.000421638488008785 0.0101827741642898 1.81339819831121 0.447368421052632 21.1 21 1 abnormal neuronal precursor proliferation 3.37716991324446e-05 0.00131261096237431 1.80154592250526 0.444444444444444 21.1 21 1 abnormal cell migration 0.000149910474139565 0.00418991353283335 1.80154592250526 0.444444444444444 21.1 21 1 abnormal trophoblast giant cell morphology 0.000676821694365671 0.0145765711232434 1.80154592250526 0.444444444444444 21.1 21 1 abnormal trigeminal ganglion morphology 0.00313830857000621 0.0481815453027199 1.80154592250526 0.444444444444444 21.1 21 1 absent inner cell mass 0.0152612798314135 0.144894784658936 1.80154592250526 0.444444444444444 21.1 21 1 distended pericardium 5.37288323052237e-05 0.00189575135261339 1.79288464403167 0.442307692307692 21.1 21 1 abnormal direction of heart looping 0.00108694074906791 0.021289489081153 1.78829926131036 0.441176470588235 21.1 21 1 abnormal axon extension 8.546908849528e-05 0.00270833576601285 1.7835304632802 0.44 21.1 21 1 astrocytosis 2.55397006221136e-06 0.000146045989189673 1.77686721123806 0.438356164383562 21.1 21 1 overriding aortic valve 0.000135938530647799 0.00388674821823449 1.77339676746611 0.4375 21.1 21 1 vasculature congestion 0.0252005860111721 0.208373242282331 1.77339676746611 0.4375 21.1 21 1 abnormal olfaction 0.0252005860111721 0.208373242282331 1.77339676746611 0.4375 21.1 21 1 increased intestinal adenocarcinoma incidence 0.0252005860111721 0.208373242282331 1.77339676746611 0.4375 21.1 21 1 small pancreas 0.0252005860111721 0.208373242282331 1.77339676746611 0.4375 21.1 21 1 decreased liver weight 4.03344754664018e-06 0.000211225279416157 1.76982856471467 0.436619718309859 21.1 21 1 increased embryonic tissue cell apoptosis 1.4695716686528e-06 9.0260729031453e-05 1.76690080861092 0.435897435897436 21.1 21 1 abnormal cell cycle 6.22295693842231e-09 7.0361842656025e-07 1.76238188071166 0.434782608695652 21.1 21 1 atrial septal defect 0.000216166762382378 0.00584472631984962 1.76238188071166 0.434782608695652 21.1 21 1 abnormal innervation pattern to muscle 0.00825893723325487 0.093595017620599 1.76238188071166 0.434782608695652 21.1 21 1 pallor 8.84956922482296e-13 2.00120940424974e-10 1.76036772999085 0.434285714285714 21.1 21 1 atrioventricular septal defect 7.72297473046035e-05 0.00250950870093472 1.75905663188013 0.433962264150943 21.1 21 1 abnormal cellular respiration 0.00280713981001802 0.045667540335513 1.75650727444262 0.433333333333333 21.1 21 1 embryonic lethality before implantation, complete penetrance 2.0805790807e-09 2.58772023162063e-07 1.75110263667511 0.432 21.1 21 1 abnormal cued conditioning behavior 0.000122364915751903 0.00358097326979834 1.74855927772569 0.431372549019608 21.1 21 1 ataxia 3.70128175691076e-14 9.69151407401635e-12 1.74580502143764 0.430693069306931 21.1 21 1 abnormal placenta morphology 2.09106193442019e-06 0.000122388624985182 1.74453497559053 0.430379746835443 21.1 21 1 abnormal optic nerve morphology 0.000546160384550987 0.0122394050141494 1.7372049967015 0.428571428571429 21.1 21 1 abnormal muscle morphology 0.000546160384550987 0.0122394050141494 1.7372049967015 0.428571428571429 21.1 21 1 abnormal reproductive system morphology 0.000546160384550987 0.0122394050141494 1.7372049967015 0.428571428571429 21.1 21 1 abnormal mitotic spindle morphology 0.00451416886814776 0.063084241907402 1.7372049967015 0.428571428571429 21.1 21 1 abnormal tumor vascularization 0.0134284718998121 0.13022738343385 1.7372049967015 0.428571428571429 21.1 21 1 absent segment of posterior cerebral artery 0.0134284718998121 0.13022738343385 1.7372049967015 0.428571428571429 21.1 21 1 increased muscle cell glucose uptake 0.0134284718998121 0.13022738343385 1.7372049967015 0.428571428571429 21.1 21 1 megacephaly 0.0418058657656568 0.269061037754389 1.7372049967015 0.428571428571429 21.1 21 1 translucent skin 0.0418058657656568 0.269061037754389 1.7372049967015 0.428571428571429 21.1 21 1 increased lactate dehydrogenase level 0.0418058657656568 0.269061037754389 1.7372049967015 0.428571428571429 21.1 21 1 abnormal voluntary movement 0.0418058657656568 0.269061037754389 1.7372049967015 0.428571428571429 21.1 21 1 vascular smooth muscle hypoplasia 0.0418058657656568 0.269061037754389 1.7372049967015 0.428571428571429 21.1 21 1 abnormal pancreas development 0.0418058657656568 0.269061037754389 1.7372049967015 0.428571428571429 21.1 21 1 lysosomal protein accumulation 0.0418058657656568 0.269061037754389 1.7372049967015 0.428571428571429 21.1 21 1 spina bifida occulta 0.0418058657656568 0.269061037754389 1.7372049967015 0.428571428571429 21.1 21 1 decreased compact bone area 0.0418058657656568 0.269061037754389 1.7372049967015 0.428571428571429 21.1 21 1 gliosis 2.4977188827213e-05 0.00101853700340479 1.7372049967015 0.428571428571429 21.1 21 1 embryonic growth arrest 1.53699892450928e-15 5.09532030468972e-13 1.73467631402799 0.427947598253275 21.1 21 1 abnormal maternal nurturing 3.93466163550765e-05 0.00147180012305643 1.72771207322225 0.426229508196721 21.1 21 1 abnormal axon morphology 5.3029058710571e-08 4.71106369794805e-06 1.72648150906754 0.425925925925926 21.1 21 1 abnormal cell nucleus morphology 0.000306746851515408 0.00804580144851024 1.72488439388801 0.425531914893617 21.1 21 1 abnormal posture 2.94777377306259e-06 0.000159404070880287 1.72272828839565 0.425 21.1 21 1 single kidney 0.00248628934839718 0.0415076829136778 1.71965747148229 0.424242424242424 21.1 21 1 abnormal nerve conduction 0.00726201174549652 0.0864318383584813 1.71493313776943 0.423076923076923 21.1 21 1 increased thymocyte apoptosis 0.00726201174549652 0.0864318383584813 1.71493313776943 0.423076923076923 21.1 21 1 decreased embryo size 1.28899715378302e-29 1.60319021001763e-26 1.71297619618962 0.422594142259414 21.1 21 1 abnormal neural tube closure 2.63469132041953e-06 0.000147276284484125 1.70929808912396 0.421686746987952 21.1 21 1 incomplete somite formation 0.00137763787116591 0.0258632015435864 1.70672771605761 0.421052631578947 21.1 21 1 short vibrissae 0.0218703889257715 0.186310248126221 1.70672771605761 0.421052631578947 21.1 21 1 abnormal stationary movement 0.0218703889257715 0.186310248126221 1.70672771605761 0.421052631578947 21.1 21 1 abnormal nasal septum morphology 0.0218703889257715 0.186310248126221 1.70672771605761 0.421052631578947 21.1 21 1 increased liver adenoma incidence 0.0218703889257715 0.186310248126221 1.70672771605761 0.421052631578947 21.1 21 1 abnormal behavioral response to xenobiotic 0.0218703889257715 0.186310248126221 1.70672771605761 0.421052631578947 21.1 21 1 decreased susceptibility to weight gain 0.0218703889257715 0.186310248126221 1.70672771605761 0.421052631578947 21.1 21 1 decreased brain weight 9.74342545782669e-05 0.00301077898463899 1.70672771605761 0.421052631578947 21.1 21 1 pale kidney 0.00396870559287543 0.0575635869520562 1.6998457494606 0.419354838709677 21.1 21 1 abnormal erythropoiesis 1.8023192359114e-07 1.37946741517834e-05 1.69860044121924 0.419047619047619 21.1 21 1 abnormal craniofacial morphology 2.80557354845396e-07 2.05260711817036e-05 1.69222881555712 0.41747572815534 21.1 21 1 abnormal mineral level 0.0697417771926808 0.369112065461263 1.68894930234868 0.416666666666667 21.1 21 1 mesocardia 0.0697417771926808 0.369112065461263 1.68894930234868 0.416666666666667 21.1 21 1 abnormal enteric nervous system morphology 0.0697417771926808 0.369112065461263 1.68894930234868 0.416666666666667 21.1 21 1 abnormal mating frequency 0.0697417771926808 0.369112065461263 1.68894930234868 0.416666666666667 21.1 21 1 impaired embryo implantation 0.0697417771926808 0.369112065461263 1.68894930234868 0.416666666666667 21.1 21 1 ear inflammation 0.0697417771926808 0.369112065461263 1.68894930234868 0.416666666666667 21.1 21 1 abnormal AMPA-mediated synaptic currents 0.0697417771926808 0.369112065461263 1.68894930234868 0.416666666666667 21.1 21 1 increased fear-related response 0.0697417771926808 0.369112065461263 1.68894930234868 0.416666666666667 21.1 21 1 abnormal vascular endothelial cell development 0.0697417771926808 0.369112065461263 1.68894930234868 0.416666666666667 21.1 21 1 abnormal nucleotide metabolism 0.0697417771926808 0.369112065461263 1.68894930234868 0.416666666666667 21.1 21 1 decreased cochlear nerve compound action potential 0.0697417771926808 0.369112065461263 1.68894930234868 0.416666666666667 21.1 21 1 small parietal bone 0.0697417771926808 0.369112065461263 1.68894930234868 0.416666666666667 21.1 21 1 abnormal amacrine cell morphology 0.0697417771926808 0.369112065461263 1.68894930234868 0.416666666666667 21.1 21 1 hemoperitoneum 0.0697417771926808 0.369112065461263 1.68894930234868 0.416666666666667 21.1 21 1 decreased mammary gland epithelial cell proliferation 0.0697417771926808 0.369112065461263 1.68894930234868 0.416666666666667 21.1 21 1 abnormal pulmonary valve cusp morphology 0.0697417771926808 0.369112065461263 1.68894930234868 0.416666666666667 21.1 21 1 increased mean corpuscular hemoglobin 6.78149609673767e-07 4.49839241083599e-05 1.67871324597081 0.414141414141414 21.1 21 1 absent long term depression 0.00633229521764395 0.0789356167663473 1.67730137612558 0.413793103448276 21.1 21 1 polychromatophilia 0.00633229521764395 0.0789356167663473 1.67730137612558 0.413793103448276 21.1 21 1 blood in lymph vessels 0.00633229521764395 0.0789356167663473 1.67730137612558 0.413793103448276 21.1 21 1 abnormal neural tube morphology 2.55475222401219e-10 3.63139780413161e-08 1.67643856677572 0.41358024691358 21.1 21 1 abnormal locomotor behavior 1.84763486476835e-06 0.000109428374431221 1.67426278667608 0.41304347826087 21.1 21 1 decreased susceptibility to hepatic steatosis 7.62216530044272e-05 0.00249475476116464 1.67286407089774 0.412698412698413 21.1 21 1 decreased circulating alanine transaminase level 4.30520034637619e-05 0.00156338479731544 1.66907931055634 0.411764705882353 21.1 21 1 abnormal bone marrow cavity morphology 0.0356822377007038 0.253598760801431 1.66907931055634 0.411764705882353 21.1 21 1 abnormal interatrial septum morphology 0.0356822377007038 0.253598760801431 1.66907931055634 0.411764705882353 21.1 21 1 hyperlipidemia 0.0356822377007038 0.253598760801431 1.66907931055634 0.411764705882353 21.1 21 1 abnormal dorsal-ventral axis patterning 0.0356822377007038 0.253598760801431 1.66907931055634 0.411764705882353 21.1 21 1 abnormal glutamate-mediated receptor currents 0.0356822377007038 0.253598760801431 1.66907931055634 0.411764705882353 21.1 21 1 absence seizures 0.0356822377007038 0.253598760801431 1.66907931055634 0.411764705882353 21.1 21 1 abnormal embryonic-extraembryonic boundary morphology 0.0356822377007038 0.253598760801431 1.66907931055634 0.411764705882353 21.1 21 1 coloboma 0.0356822377007038 0.253598760801431 1.66907931055634 0.411764705882353 21.1 21 1 enhanced behavioral response to cocaine 0.0356822377007038 0.253598760801431 1.66907931055634 0.411764705882353 21.1 21 1 impaired balance 6.00468900103719e-07 4.0922366822137e-05 1.66907931055634 0.411764705882353 21.1 21 1 abnormal response to novel object 0.000377136888261196 0.00915246838585098 1.66907931055634 0.411764705882353 21.1 21 1 increased tumor incidence 4.13103148916889e-08 3.73670575611186e-06 1.66715640812482 0.411290322580645 21.1 21 1 decreased cell proliferation 2.45839699909806e-11 4.20785932467373e-09 1.66521271755891 0.410810810810811 21.1 21 1 failure of heart looping 0.00191124630719892 0.0333629837835602 1.66296546692793 0.41025641025641 21.1 21 1 pale yolk sac 7.83300197790375e-06 0.000385833513268031 1.66046100086328 0.409638554216867 21.1 21 1 abnormal tail movements 0.0188074407864865 0.163578702644703 1.65824113321506 0.409090909090909 21.1 21 1 increased skin papilloma incidence 0.0188074407864865 0.163578702644703 1.65824113321506 0.409090909090909 21.1 21 1 aphakia 0.0188074407864865 0.163578702644703 1.65824113321506 0.409090909090909 21.1 21 1 abnormal vascular branching morphogenesis 0.0188074407864865 0.163578702644703 1.65824113321506 0.409090909090909 21.1 21 1 abnormal channel response 0.0188074407864865 0.163578702644703 1.65824113321506 0.409090909090909 21.1 21 1 abnormal cerebral cortex pyramidal cell morphology 0.0188074407864865 0.163578702644703 1.65824113321506 0.409090909090909 21.1 21 1 impaired swimming 6.70716339897307e-05 0.0022663321939066 1.65824113321506 0.409090909090909 21.1 21 1 embryonic lethality during organogenesis, complete penetrance 7.09212030147869e-31 1.17610994999522e-27 1.65758310101934 0.408928571428571 21.1 21 1 embryonic lethality between implantation and somite formation, complete penetrance 3.14360028223137e-14 8.68856189116727e-12 1.65448094923952 0.408163265306122 21.1 21 1 increased cell proliferation 0.000330496371960799 0.0083019792060595 1.65141709562982 0.407407407407407 21.1 21 1 abnormal maxilla morphology 0.000330496371960799 0.0083019792060595 1.65141709562982 0.407407407407407 21.1 21 1 impaired limb coordination 0.000330496371960799 0.0083019792060595 1.65141709562982 0.407407407407407 21.1 21 1 abnormal eye muscle morphology 0.0100970576786461 0.10508966935411 1.65141709562982 0.407407407407407 21.1 21 1 decreased circulating fructosamine level 0.0100970576786461 0.10508966935411 1.65141709562982 0.407407407407407 21.1 21 1 scoliosis 0.00548924967095782 0.0736092105472106 1.64672556978996 0.40625 21.1 21 1 abnormal spongiotrophoblast layer morphology 0.00548924967095782 0.0736092105472106 1.64672556978996 0.40625 21.1 21 1 abnormal breathing pattern 0.00301160038809375 0.0469677489992678 1.64330202390682 0.405405405405405 21.1 21 1 abnormal somite development 1.88235709215068e-05 0.000814324046386927 1.64191527114403 0.40506329113924 21.1 21 1 anophthalmia 6.05628801246292e-06 0.000310618895484567 1.63960921036995 0.404494382022472 21.1 21 1 abnormal embryo development 2.50357839420718e-08 2.39525048291936e-06 1.63927432286783 0.404411764705882 21.1 21 1 decreased birth body size 3.62091552675497e-07 2.53719080924028e-05 1.63561406122188 0.403508771929825 21.1 21 1 hydrops fetalis 5.15172927437756e-05 0.00184172829181525 1.63265099227039 0.402777777777778 21.1 21 1 preweaning lethality, complete penetrance 2.30211121034471e-38 1.14530032714649e-34 1.63234667708078 0.402702702702703 21.1 21 1 perinatal lethality, incomplete penetrance 1.10904089999787e-12 2.39890368586496e-10 1.63215277713695 0.402654867256637 21.1 21 1 abnormal developmental patterning 1.64916151347323e-05 0.000732633430595 1.63127786275628 0.402439024390244 21.1 21 1 abnormal extraembryonic tissue morphology 1.71705602691834e-06 0.000102919924505045 1.62933932697166 0.401960784313726 21.1 21 1 abnormal pericardium morphology 0.0302653837150458 0.230582364444644 1.62139133025473 0.4 21.1 21 1 abnormal vascular regression 0.0302653837150458 0.230582364444644 1.62139133025473 0.4 21.1 21 1 abnormal hearing physiology 0.0302653837150458 0.230582364444644 1.62139133025473 0.4 21.1 21 1 decreased myocardial infarction size 0.0302653837150458 0.230582364444644 1.62139133025473 0.4 21.1 21 1 abnormal postnatal subventricular zone morphology 0.0302653837150458 0.230582364444644 1.62139133025473 0.4 21.1 21 1 increased skin tumor incidence 0.0302653837150458 0.230582364444644 1.62139133025473 0.4 21.1 21 1 decreased muscle cell glucose uptake 0.0302653837150458 0.230582364444644 1.62139133025473 0.4 21.1 21 1 abnormal contextual conditioning behavior 0.000448736687803613 0.0107330049126104 1.62139133025473 0.4 21.1 21 1 trabecula carnea hypoplasia 0.00144340573067404 0.0266389536746352 1.62139133025473 0.4 21.1 21 1 cardiomyopathy 0.00144340573067404 0.0266389536746352 1.62139133025473 0.4 21.1 21 1 abnormal liver development 0.00473827300989513 0.0646412875736249 1.62139133025473 0.4 21.1 21 1 increased carcinoma incidence 0.00473827300989513 0.0646412875736249 1.62139133025473 0.4 21.1 21 1 abnormal embryonic epiblast morphology 0.00473827300989513 0.0646412875736249 1.62139133025473 0.4 21.1 21 1 disorganized myocardium 0.00868239882272789 0.0962025259311164 1.62139133025473 0.4 21.1 21 1 enhanced paired-pulse facilitation 0.00868239882272789 0.0962025259311164 1.62139133025473 0.4 21.1 21 1 liver hemorrhage 0.00868239882272789 0.0962025259311164 1.62139133025473 0.4 21.1 21 1 abnormal brain vasculature morphology 0.00868239882272789 0.0962025259311164 1.62139133025473 0.4 21.1 21 1 spontaneous skin ulceration 0.0160849164877502 0.150258923540435 1.62139133025473 0.4 21.1 21 1 decreased hepatocyte number 0.0583200736256645 0.32166559455397 1.62139133025473 0.4 21.1 21 1 abnormal pup retrieval 0.0583200736256645 0.32166559455397 1.62139133025473 0.4 21.1 21 1 greasy coat 0.0583200736256645 0.32166559455397 1.62139133025473 0.4 21.1 21 1 abnormal embryo size 7.49321351512155e-07 4.86054377165089e-05 1.61421703233325 0.398230088495575 21.1 21 1 azoospermia 6.50735093363286e-09 7.08410190258433e-07 1.60609518562969 0.39622641509434 21.1 21 1 decreased heart weight 3.41423574161963e-05 0.0013167304507409 1.601374153338 0.395061728395062 21.1 21 1 prenatal lethality, incomplete penetrance 1.74111447597438e-15 5.09532030468972e-13 1.60005723380401 0.394736842105263 21.1 21 1 abnormal ovarian folliculogenesis 0.00744117388062222 0.0879331117721984 1.59682479494784 0.393939393939394 21.1 21 1 decreased exploration in new environment 2.96708347785373e-05 0.00117602276500824 1.59243791364304 0.392857142857143 21.1 21 1 abnormal somite shape 0.0137095151442627 0.131669571124917 1.59243791364304 0.392857142857143 21.1 21 1 absent corpus callosum 0.0137095151442627 0.131669571124917 1.59243791364304 0.392857142857143 21.1 21 1 abnormal brainstem morphology 0.0137095151442627 0.131669571124917 1.59243791364304 0.392857142857143 21.1 21 1 abnormal renal tubule epithelium morphology 0.0137095151442627 0.131669571124917 1.59243791364304 0.392857142857143 21.1 21 1 prolonged QRS complex duration 0.0137095151442627 0.131669571124917 1.59243791364304 0.392857142857143 21.1 21 1 abnormal gluconeogenesis 0.00107803333124822 0.0212590513101143 1.58959934338699 0.392156862745098 21.1 21 1 abnormal brain morphology 1.15066308452841e-08 1.19261434281851e-06 1.5861436926405 0.391304347826087 21.1 21 1 abnormal testis morphology 1.33203105784774e-06 8.28356814099066e-05 1.5861436926405 0.391304347826087 21.1 21 1 abnormal cell death 0.00193764565285231 0.0336027425725272 1.5861436926405 0.391304347826087 21.1 21 1 abnormal cranial nerve morphology 0.0255886216421354 0.208373242282331 1.5861436926405 0.391304347826087 21.1 21 1 conjunctivitis 0.0255886216421354 0.208373242282331 1.5861436926405 0.391304347826087 21.1 21 1 abnormal Wolffian duct morphology 0.0255886216421354 0.208373242282331 1.5861436926405 0.391304347826087 21.1 21 1 abnormal palatal shelf fusion at midline 0.0255886216421354 0.208373242282331 1.5861436926405 0.391304347826087 21.1 21 1 decreased effector memory CD8-positive, alpha-beta T cell number 0.0255886216421354 0.208373242282331 1.5861436926405 0.391304347826087 21.1 21 1 abnormal vertebral artery topology 0.0255886216421354 0.208373242282331 1.5861436926405 0.391304347826087 21.1 21 1 abnormal mammary gland development 0.00350015095492945 0.0522920450473693 1.58184520024852 0.390243902439024 21.1 21 1 scaly skin 0.00350015095492945 0.0522920450473693 1.58184520024852 0.390243902439024 21.1 21 1 thick ventricular wall 0.00350015095492945 0.0522920450473693 1.58184520024852 0.390243902439024 21.1 21 1 abnormal forebrain development 0.000142157823167287 0.00401838164918893 1.5763526821921 0.388888888888889 21.1 21 1 abnormal uterus morphology 0.00636244870820207 0.0789356167663473 1.5763526821921 0.388888888888889 21.1 21 1 abnormal pharyngeal arch morphology 0.00636244870820207 0.0789356167663473 1.5763526821921 0.388888888888889 21.1 21 1 abnormal phrenic nerve morphology 0.0486773927084339 0.294969584317246 1.5763526821921 0.388888888888889 21.1 21 1 abnormal body wall morphology 0.0486773927084339 0.294969584317246 1.5763526821921 0.388888888888889 21.1 21 1 abnormal anterior eye segment morphology 0.0486773927084339 0.294969584317246 1.5763526821921 0.388888888888889 21.1 21 1 abnormal pregnancy 0.0486773927084339 0.294969584317246 1.5763526821921 0.388888888888889 21.1 21 1 decreased tumor latency 0.0486773927084339 0.294969584317246 1.5763526821921 0.388888888888889 21.1 21 1 primary atelectasis 0.0486773927084339 0.294969584317246 1.5763526821921 0.388888888888889 21.1 21 1 increased effector memory CD4-positive, alpha-beta T cell number 0.0486773927084339 0.294969584317246 1.5763526821921 0.388888888888889 21.1 21 1 increased effector memory CD8-positive, alpha-beta T cell number 0.0486773927084339 0.294969584317246 1.5763526821921 0.388888888888889 21.1 21 1 abnormal aerobic respiration 0.0486773927084339 0.294969584317246 1.5763526821921 0.388888888888889 21.1 21 1 abnormal hypoglossal nerve topology 0.0486773927084339 0.294969584317246 1.5763526821921 0.388888888888889 21.1 21 1 prenatal lethality, complete penetrance 1.50015771476885e-13 3.55394506236907e-11 1.57473258693805 0.388489208633094 21.1 21 1 abnormal embryonic tissue morphology 8.09706447296467e-08 6.82760944966088e-06 1.57175690177754 0.387755102040816 21.1 21 1 polydactyly 1.09877140400905e-05 0.000515696956126888 1.57175690177754 0.387755102040816 21.1 21 1 increased T cell derived lymphoma incidence 0.00166552708911656 0.0293829690367194 1.57175690177754 0.387755102040816 21.1 21 1 increased lung adenoma incidence 0.0116594682310557 0.115780148601801 1.56908838411748 0.387096774193548 21.1 21 1 decreased thymus weight 0.0116594682310557 0.115780148601801 1.56908838411748 0.387096774193548 21.1 21 1 preaxial polydactyly 0.0116594682310557 0.115780148601801 1.56908838411748 0.387096774193548 21.1 21 1 embryonic lethality during organogenesis, incomplete penetrance 2.53740260784345e-11 4.20785932467373e-09 1.56851987383338 0.38695652173913 21.1 21 1 abnormal astrocyte morphology 0.0029993659094122 0.0469240421362443 1.56611662581423 0.386363636363636 21.1 21 1 abnormal amino acid level 0.0029993659094122 0.0469240421362443 1.56611662581423 0.386363636363636 21.1 21 1 abnormal heart development 3.49434868911165e-08 3.23215685190055e-06 1.56495049280915 0.386075949367089 21.1 21 1 incomplete embryo turning 0.000799280236037513 0.0165674318918557 1.56450040638614 0.385964912280702 21.1 21 1 limb grasping 4.30373007260211e-09 5.09787074076084e-07 1.55903012524493 0.384615384615385 21.1 21 1 decreased startle reflex 2.31658363264809e-06 0.000134011669446794 1.55903012524493 0.384615384615385 21.1 21 1 increased grip strength 2.9414861990299e-05 0.00117602276500824 1.55903012524493 0.384615384615385 21.1 21 1 abnormal placenta vasculature 0.00142953683921156 0.0266389536746352 1.55903012524493 0.384615384615385 21.1 21 1 no spontaneous movement 0.0215992319516587 0.185910344220592 1.55903012524493 0.384615384615385 21.1 21 1 decreased circulating glycerol level 0.0215992319516587 0.185910344220592 1.55903012524493 0.384615384615385 21.1 21 1 short premaxilla 0.0954728209662247 0.441505332994711 1.55903012524493 0.384615384615385 21.1 21 1 short hair 0.0954728209662247 0.441505332994711 1.55903012524493 0.384615384615385 21.1 21 1 uterus hypoplasia 0.0954728209662247 0.441505332994711 1.55903012524493 0.384615384615385 21.1 21 1 lymphoid hypoplasia 0.0954728209662247 0.441505332994711 1.55903012524493 0.384615384615385 21.1 21 1 abnormal coping response 0.0954728209662247 0.441505332994711 1.55903012524493 0.384615384615385 21.1 21 1 abnormal afterhyperpolarization 0.0954728209662247 0.441505332994711 1.55903012524493 0.384615384615385 21.1 21 1 small interparietal bone 0.0954728209662247 0.441505332994711 1.55903012524493 0.384615384615385 21.1 21 1 decreased endocochlear potential 0.0954728209662247 0.441505332994711 1.55903012524493 0.384615384615385 21.1 21 1 decreased luteinizing hormone level 0.0954728209662247 0.441505332994711 1.55903012524493 0.384615384615385 21.1 21 1 small pituitary gland 0.0954728209662247 0.441505332994711 1.55903012524493 0.384615384615385 21.1 21 1 increased circulating thyroxine level 0.0954728209662247 0.441505332994711 1.55903012524493 0.384615384615385 21.1 21 1 increased prostaglandin level 0.0954728209662247 0.441505332994711 1.55903012524493 0.384615384615385 21.1 21 1 abnormal aorta tunica media morphology 0.0954728209662247 0.441505332994711 1.55903012524493 0.384615384615385 21.1 21 1 absent hypoglossal nerve 0.0954728209662247 0.441505332994711 1.55903012524493 0.384615384615385 21.1 21 1 abnormal heart looping 0.00543096674735373 0.0732223836533464 1.55903012524493 0.384615384615385 21.1 21 1 small lens 0.00543096674735373 0.0732223836533464 1.55903012524493 0.384615384615385 21.1 21 1 abnormal neuron morphology 1.44514456053593e-05 0.00065545963879926 1.55588056943636 0.383838383838384 21.1 21 1 muscular ventricular septal defect 0.000686868248755069 0.0147291790411917 1.55383335816078 0.383333333333333 21.1 21 1 pulmonary hypoplasia 0.0025666842263649 0.0427065352045665 1.55239595449921 0.382978723404255 21.1 21 1 hemorrhage 3.77917944342859e-11 6.06497346163136e-09 1.55239595449921 0.382978723404255 21.1 21 1 decreased mean corpuscular hemoglobin 0.00033207916824238 0.0083019792060595 1.54985935980232 0.382352941176471 21.1 21 1 abnormal nervous system development 0.00990209895990934 0.103906060943932 1.54985935980232 0.382352941176471 21.1 21 1 impaired coordination 1.68490837124653e-15 5.09532030468972e-13 1.54641369648572 0.38150289017341 21.1 21 1 arrest of spermatogenesis 7.86901220795612e-05 0.00250950870093472 1.54418221929022 0.380952380952381 21.1 21 1 spina bifida 0.00463022366098596 0.0645248255277455 1.54418221929022 0.380952380952381 21.1 21 1 abnormal scapula morphology 0.040626560216728 0.264551226542175 1.54418221929022 0.380952380952381 21.1 21 1 complete atrioventricular septal defect 0.040626560216728 0.264551226542175 1.54418221929022 0.380952380952381 21.1 21 1 increased B cell derived lymphoma incidence 0.0021940673166368 0.0374222553728758 1.54032176374199 0.38 21.1 21 1 abnormal placenta labyrinth morphology 0.00013876611248212 0.00394492234056312 1.53929556669753 0.379746835443038 21.1 21 1 abnormal retinal pigmentation 6.77284258740949e-05 0.0022663321939066 1.53752626144845 0.379310344827586 21.1 21 1 abnormal embryonic erythropoiesis 0.0182178162105297 0.163578702644703 1.53752626144845 0.379310344827586 21.1 21 1 abnormal myocardial trabeculae morphology 0.00394405601793178 0.0575635869520562 1.53131403412947 0.377777777777778 21.1 21 1 abnormal behavior 2.54707252357801e-12 4.69321696474096e-10 1.53099001507866 0.377697841726619 21.1 21 1 perimembraneous ventricular septal defect 0.000433495264049259 0.0104185455973191 1.52739762995011 0.376811594202899 21.1 21 1 increased circulating alkaline phosphatase level 1.00862879354001e-07 8.09343265784119e-06 1.52630973990029 0.376543209876543 21.1 21 1 abnormal lung development 0.000102443453161386 0.00311132555954345 1.52601536965151 0.376470588235294 21.1 21 1 increased sacral vertebrae number 0.000768273394709586 0.0160594963810092 1.52005437211381 0.375 21.1 21 1 abnormal digestive system morphology 0.0339302415389229 0.244287918460407 1.52005437211381 0.375 21.1 21 1 abnormal sensory capabilities/reflexes/nociception 0.0339302415389229 0.244287918460407 1.52005437211381 0.375 21.1 21 1 abnormal hair follicle orientation 0.0781917661943598 0.403950193994746 1.52005437211381 0.375 21.1 21 1 delayed hair appearance 0.0781917661943598 0.403950193994746 1.52005437211381 0.375 21.1 21 1 disorganized retinal layers 0.0781917661943598 0.403950193994746 1.52005437211381 0.375 21.1 21 1 reduced male mating frequency 0.0781917661943598 0.403950193994746 1.52005437211381 0.375 21.1 21 1 disorganized yolk sac vascular plexus 0.0781917661943598 0.403950193994746 1.52005437211381 0.375 21.1 21 1 increased pancreatic beta cell number 0.0781917661943598 0.403950193994746 1.52005437211381 0.375 21.1 21 1 abnormal amnion morphology 0.0781917661943598 0.403950193994746 1.52005437211381 0.375 21.1 21 1 decreased circulating prolactin level 0.0781917661943598 0.403950193994746 1.52005437211381 0.375 21.1 21 1 decreased circulating triiodothyronine level 0.0781917661943598 0.403950193994746 1.52005437211381 0.375 21.1 21 1 impaired behavioral response to addictive substance 0.0781917661943598 0.403950193994746 1.52005437211381 0.375 21.1 21 1 decreased liver cholesterol level 0.0781917661943598 0.403950193994746 1.52005437211381 0.375 21.1 21 1 decreased skeletal muscle weight 0.0781917661943598 0.403950193994746 1.52005437211381 0.375 21.1 21 1 dilated respiratory conducting tubes 0.0781917661943598 0.403950193994746 1.52005437211381 0.375 21.1 21 1 decreased fibroblast apoptosis 0.0781917661943598 0.403950193994746 1.52005437211381 0.375 21.1 21 1 reduced female fertility 2.79347831914162e-10 3.86043184381377e-08 1.52005437211381 0.375 21.1 21 1 small testis 9.47898171997212e-12 1.68421193060219e-09 1.51271111427751 0.373188405797101 21.1 21 1 internal hemorrhage 0.000656721995616289 0.0142672136602229 1.51249191255105 0.373134328358209 21.1 21 1 distended abdomen 0.00285671249546127 0.045667540335513 1.51011937621764 0.372549019607843 21.1 21 1 abnormal gastrulation 0.00285671249546127 0.045667540335513 1.51011937621764 0.372549019607843 21.1 21 1 increased lung adenocarcinoma incidence 0.00285671249546127 0.045667540335513 1.51011937621764 0.372549019607843 21.1 21 1 edema 8.3133595804075e-08 6.89316065208789e-06 1.50827100488812 0.372093023255814 21.1 21 1 abnormal double-strand DNA break repair 0.00604065585112973 0.0768600073129678 1.50827100488812 0.372093023255814 21.1 21 1 holoprosencephaly 0.012953450657645 0.126857120121622 1.50557766380796 0.371428571428571 21.1 21 1 abnormal hippocampus pyramidal cell morphology 0.012953450657645 0.126857120121622 1.50557766380796 0.371428571428571 21.1 21 1 abnormal motor capabilities/coordination/movement 2.79183882113164e-06 0.000154326645945888 1.504700287547 0.371212121212121 21.1 21 1 prenatal lethality 0.00116365812897908 0.0223033744539917 1.50370970144592 0.370967741935484 21.1 21 1 decreased susceptibility to pharmacologically induced seizures 0.0283652168181366 0.220917176697439 1.50128826875438 0.37037037037037 21.1 21 1 abnormal fetal cardiomyocyte proliferation 0.0283652168181366 0.220917176697439 1.50128826875438 0.37037037037037 21.1 21 1 seminiferous tubule degeneration 0.000479262198208602 0.0113624471963252 1.49923170948211 0.36986301369863 21.1 21 1 abnormal hepatocyte morphology 2.00102201294288e-05 0.000850861924306909 1.49723073289288 0.369369369369369 21.1 21 1 preweaning lethality, incomplete penetrance 4.63983872897492e-16 1.77563059051155e-13 1.49651644785125 0.36919315403423 21.1 21 1 flaky skin 0.0643148115816537 0.35045584624176 1.49338675155041 0.368421052631579 21.1 21 1 decreased germ cell number 0.0643148115816537 0.35045584624176 1.49338675155041 0.368421052631579 21.1 21 1 abnormal digestive system development 0.0643148115816537 0.35045584624176 1.49338675155041 0.368421052631579 21.1 21 1 maternal imprinting 0.0643148115816537 0.35045584624176 1.49338675155041 0.368421052631579 21.1 21 1 abnormal optic vesicle formation 0.0643148115816537 0.35045584624176 1.49338675155041 0.368421052631579 21.1 21 1 decreased liver regeneration 0.0643148115816537 0.35045584624176 1.49338675155041 0.368421052631579 21.1 21 1 decreased circulating magnesium level 0.0643148115816537 0.35045584624176 1.49338675155041 0.368421052631579 21.1 21 1 decreased liver glycogen level 0.0643148115816537 0.35045584624176 1.49338675155041 0.368421052631579 21.1 21 1 abnormal spatial learning 3.19736379877329e-07 2.27241212841387e-05 1.49207791127736 0.368098159509202 21.1 21 1 extramedullary hematopoiesis 3.48887909421e-05 0.00132497507585456 1.49137410094185 0.367924528301887 21.1 21 1 increased sarcoma incidence 0.00433980643299229 0.06228308744546 1.48903285431557 0.36734693877551 21.1 21 1 abnormal visceral yolk sac morphology 0.000349328877838389 0.00856113875490634 1.48798571447428 0.367088607594937 21.1 21 1 reduced fertility 2.63152167740817e-06 0.000147276284484125 1.48724744321927 0.366906474820144 21.1 21 1 abnormal eating behavior 0.00175693033010508 0.0307772126488478 1.48627538606684 0.366666666666667 21.1 21 1 delayed eyelid opening 0.0237383210139939 0.199153704965632 1.48627538606684 0.366666666666667 21.1 21 1 lethality at weaning, incomplete penetrance 0.00921682063234265 0.100556321591896 1.48297987523298 0.365853658536585 21.1 21 1 hydroencephaly 2.18888699700862e-05 0.000915101916816627 1.4804007797978 0.365217391304348 21.1 21 1 kidney cysts 0.00061380292573088 0.0135718646911606 1.47897182151614 0.364864864864865 21.1 21 1 retinal degeneration 0.000106131853791528 0.00320003619765363 1.47783063955509 0.364583333333333 21.1 21 1 postnatal growth retardation 3.27877961472137e-22 2.03899107290485e-19 1.47700272323041 0.36437908496732 21.1 21 1 lethality, incomplete penetrance 0.00777853581782549 0.0885542693219263 1.47399211841339 0.363636363636364 21.1 21 1 abnormal abdominal fat pad morphology 0.0530946284625803 0.315385673484007 1.47399211841339 0.363636363636364 21.1 21 1 increased coping response 0.0530946284625803 0.315385673484007 1.47399211841339 0.363636363636364 21.1 21 1 parakeratosis 0.0530946284625803 0.315385673484007 1.47399211841339 0.363636363636364 21.1 21 1 abnormal basement membrane morphology 0.0530946284625803 0.315385673484007 1.47399211841339 0.363636363636364 21.1 21 1 cleft upper lip 0.0530946284625803 0.315385673484007 1.47399211841339 0.363636363636364 21.1 21 1 decreased circulating estradiol level 0.0530946284625803 0.315385673484007 1.47399211841339 0.363636363636364 21.1 21 1 abnormal sperm midpiece morphology 0.0530946284625803 0.315385673484007 1.47399211841339 0.363636363636364 21.1 21 1 abnormal heart morphology 3.12582222942237e-09 3.79291843692105e-07 1.47399211841339 0.363636363636364 21.1 21 1 abnormal CNS synaptic transmission 9.06565664556799e-05 0.00283927439310074 1.47399211841339 0.363636363636364 21.1 21 1 abnormal skin morphology 0.00126986008412419 0.024112801215717 1.47399211841339 0.363636363636364 21.1 21 1 abnormal rostral-caudal axis patterning 0.00311807008695601 0.0480260021133318 1.47399211841339 0.363636363636364 21.1 21 1 hypoactivity 4.3298752571137e-14 1.07705647020703e-11 1.473014670059 0.363395225464191 21.1 21 1 abnormal liver morphology 1.88898032400469e-07 1.42389047150353e-05 1.47193347020332 0.363128491620112 21.1 21 1 decreased total body fat amount 1.63381505301825e-12 3.36032875462298e-10 1.46847568084448 0.362275449101796 21.1 21 1 decreased body size 6.29278946771912e-28 6.26132552038052e-25 1.4679890176805 0.362155388471178 21.1 21 1 male infertility 5.10098466312409e-18 2.53773986990424e-15 1.46666611384871 0.36182902584493 21.1 21 1 hepatic necrosis 0.00656723552935817 0.0796098401085913 1.46615173480481 0.361702127659574 21.1 21 1 neonatal lethality, incomplete penetrance 5.31993890490471e-10 7.15316109510836e-08 1.46548831773024 0.361538461538462 21.1 21 1 decreased body length 1.95201084473424e-10 2.85625116251554e-08 1.46457793517535 0.361313868613139 21.1 21 1 abnormal liver physiology 0.00011490576762111 0.00342309098152709 1.45925219722926 0.36 21.1 21 1 decreased circulating alkaline phosphatase level 0.00554678468594226 0.0739819137066026 1.45925219722926 0.36 21.1 21 1 decreased respiratory quotient 0.00554678468594226 0.0739819137066026 1.45925219722926 0.36 21.1 21 1 abnormal nest building behavior 0.0439682368802077 0.280798431937142 1.45925219722926 0.36 21.1 21 1 abnormal preimplantation embryo development 0.0439682368802077 0.280798431937142 1.45925219722926 0.36 21.1 21 1 abnormal eye morphology 6.26868655511403e-06 0.000318231791956044 1.45808572864634 0.359712230215827 21.1 21 1 seizures 4.11537467430275e-05 0.00151659177812268 1.45782992413254 0.359649122807018 21.1 21 1 abnormal excitatory postsynaptic currents 0.000663377452155361 0.0143491427150997 1.45509478356194 0.358974358974359 21.1 21 1 abnormal coat/ hair morphology 0.00468678563752122 0.0645893588550361 1.45313373937924 0.358490566037736 21.1 21 1 abnormal mesoderm development 0.00468678563752122 0.0645893588550361 1.45313373937924 0.358490566037736 21.1 21 1 enlarged kidney 0.00468678563752122 0.0645893588550361 1.45313373937924 0.358490566037736 21.1 21 1 increased circulating bilirubin level 0.00468678563752122 0.0645893588550361 1.45313373937924 0.358490566037736 21.1 21 1 increased exploration in new environment 0.000564045218752751 0.0125835200147755 1.45124532646257 0.358024691358025 21.1 21 1 decreased birth weight 0.000199662120967651 0.00545779698798936 1.45071855864897 0.357894736842105 21.1 21 1 abnormal bone structure 1.61460070263012e-07 1.25509976493513e-05 1.44917100761109 0.357512953367876 21.1 21 1 abnormal nervous system electrophysiology 0.000479620886679052 0.0113624471963252 1.44767083058458 0.357142857142857 21.1 21 1 abnormal eye development 0.00396170299092415 0.0575635869520562 1.44767083058458 0.357142857142857 21.1 21 1 disheveled coat 0.011764930060874 0.116131998120731 1.44767083058458 0.357142857142857 21.1 21 1 rib bifurcation 0.0365072733036222 0.257988188473751 1.44767083058458 0.357142857142857 21.1 21 1 abnormal circulating cholesterol level 0.0365072733036222 0.257988188473751 1.44767083058458 0.357142857142857 21.1 21 1 abnormal retinal inner nuclear layer morphology 0.0365072733036222 0.257988188473751 1.44767083058458 0.357142857142857 21.1 21 1 abnormal blood flow velocity 0.125287796077651 0.513009699988737 1.44767083058458 0.357142857142857 21.1 21 1 abnormal fluid regulation 0.125287796077651 0.513009699988737 1.44767083058458 0.357142857142857 21.1 21 1 abnormal prepulse inhibition 0.125287796077651 0.513009699988737 1.44767083058458 0.357142857142857 21.1 21 1 failure of zygotic cell division 0.125287796077651 0.513009699988737 1.44767083058458 0.357142857142857 21.1 21 1 abnormal vascular endothelial cell migration 0.125287796077651 0.513009699988737 1.44767083058458 0.357142857142857 21.1 21 1 abnormal imprinting 0.125287796077651 0.513009699988737 1.44767083058458 0.357142857142857 21.1 21 1 decreased CNS synapse formation 0.125287796077651 0.513009699988737 1.44767083058458 0.357142857142857 21.1 21 1 sternebra fusion 0.125287796077651 0.513009699988737 1.44767083058458 0.357142857142857 21.1 21 1 abnormal renal tubule epithelial cell primary cilium morphology 0.125287796077651 0.513009699988737 1.44767083058458 0.357142857142857 21.1 21 1 reduced male fertility 1.57987791423805e-08 1.57197852466686e-06 1.44639534967658 0.356828193832599 21.1 21 1 abnormal vitelline vasculature morphology 5.18275298199265e-05 0.00184172829181525 1.44515314218356 0.356521739130435 21.1 21 1 abnormal seminiferous tubule morphology 5.75602851434946e-06 0.000298294186030089 1.44370460913092 0.356164383561644 21.1 21 1 abnormal gait 5.60634276160706e-11 8.71611101218597e-09 1.44298581171537 0.355987055016181 21.1 21 1 thin ventricular wall 0.000346872850493211 0.00856113875490634 1.4412367380042 0.355555555555556 21.1 21 1 abnormal autopod morphology 0.00989411087983575 0.103906060943932 1.4412367380042 0.355555555555556 21.1 21 1 lethality at weaning, complete penetrance 0.00989411087983575 0.103906060943932 1.4412367380042 0.355555555555556 21.1 21 1 abnormal retinal photoreceptor layer morphology 0.0303816900446099 0.231114538183386 1.43833101877436 0.354838709677419 21.1 21 1 abnormal myocardium layer morphology 0.000835796277270558 0.0169717815486572 1.43667586225103 0.354430379746835 21.1 21 1 decreased food intake 0.000835796277270558 0.0169717815486572 1.43667586225103 0.354430379746835 21.1 21 1 vertebral transformation 0.00832745798919935 0.0937392323529767 1.43560690699638 0.354166666666667 21.1 21 1 curly tail 0.00832745798919935 0.0937392323529767 1.43560690699638 0.354166666666667 21.1 21 1 hyperactivity 1.68860741438341e-12 3.36032875462298e-10 1.4312821042006 0.353099730458221 21.1 21 1 abnormal adipose tissue morphology 0.101378781736354 0.441505332994711 1.43063940904829 0.352941176470588 21.1 21 1 enlarged sebaceous gland 0.101378781736354 0.441505332994711 1.43063940904829 0.352941176470588 21.1 21 1 decreased vasoconstriction 0.101378781736354 0.441505332994711 1.43063940904829 0.352941176470588 21.1 21 1 abnormal testis development 0.101378781736354 0.441505332994711 1.43063940904829 0.352941176470588 21.1 21 1 abnormal ectoplacental cone morphology 0.101378781736354 0.441505332994711 1.43063940904829 0.352941176470588 21.1 21 1 common atrium 0.101378781736354 0.441505332994711 1.43063940904829 0.352941176470588 21.1 21 1 abnormal ductus venosus valve morphology 0.101378781736354 0.441505332994711 1.43063940904829 0.352941176470588 21.1 21 1 abnormal cell cytoskeleton morphology 0.101378781736354 0.441505332994711 1.43063940904829 0.352941176470588 21.1 21 1 increased heart weight 1.44925749282248e-05 0.00065545963879926 1.42892401407341 0.352517985611511 21.1 21 1 abnormal suckling behavior 0.000511636262526219 0.011839025144502 1.42792986471297 0.352272727272727 21.1 21 1 abnormal ovary morphology 0.00171925110119059 0.0302235838460183 1.42728110057635 0.352112676056338 21.1 21 1 abnormal small intestine morphology 0.00591196448813449 0.0767937945913031 1.42622385531666 0.351851851851852 21.1 21 1 abnormal apoptosis 0.00591196448813449 0.0767937945913031 1.42622385531666 0.351851851851852 21.1 21 1 abnormal cell adhesion 0.00591196448813449 0.0767937945913031 1.42622385531666 0.351851851851852 21.1 21 1 decreased circulating chloride level 0.0211620142922569 0.183097428006918 1.42419508738591 0.351351351351351 21.1 21 1 abnormal cell morphology 9.52344609390369e-05 0.00296119651982318 1.42227309671468 0.350877192982456 21.1 21 1 abnormal craniofacial bone morphology 0.00498622151375737 0.0675925123458935 1.42227309671468 0.350877192982456 21.1 21 1 abnormal facial morphology 0.00498622151375737 0.0675925123458935 1.42227309671468 0.350877192982456 21.1 21 1 postnatal lethality, incomplete penetrance 8.17148774352199e-18 3.69574104763835e-15 1.42014469507346 0.350352112676056 21.1 21 1 abnormal cell proliferation 0.0826491188944427 0.412562569733648 1.41871741397289 0.35 21.1 21 1 small gonad 0.0826491188944427 0.412562569733648 1.41871741397289 0.35 21.1 21 1 anencephaly 0.0826491188944427 0.412562569733648 1.41871741397289 0.35 21.1 21 1 absent placental labyrinth 0.0826491188944427 0.412562569733648 1.41871741397289 0.35 21.1 21 1 abnormal male reproductive system physiology 0.0826491188944427 0.412562569733648 1.41871741397289 0.35 21.1 21 1 abnormal physiological neovascularization 0.0826491188944427 0.412562569733648 1.41871741397289 0.35 21.1 21 1 abnormal response to tactile stimuli 0.0826491188944427 0.412562569733648 1.41871741397289 0.35 21.1 21 1 abnormal sperm mitochondrial sheath morphology 0.0826491188944427 0.412562569733648 1.41871741397289 0.35 21.1 21 1 nuclear cataracts 0.0826491188944427 0.412562569733648 1.41871741397289 0.35 21.1 21 1 decreased double-positive T cell number 0.000266561736482795 0.0071683494000103 1.41871741397289 0.35 21.1 21 1 increased or absent threshold for auditory brainstem response 1.06660142616574e-09 1.39640581451962e-07 1.41661353248899 0.349480968858132 21.1 21 1 cyanosis 6.6803202849957e-07 4.49116127268292e-05 1.41449504071702 0.348958333333333 21.1 21 1 abnormal axon guidance 0.01483150553038 0.141353908072108 1.41400406708261 0.348837209302326 21.1 21 1 decreased body weight 1.3750639830437e-36 3.42047165782121e-33 1.41118671918374 0.348142164781906 21.1 21 1 abnormal nervous system physiology 0.000118384824202563 0.00349587599555531 1.40990550456933 0.347826086956522 21.1 21 1 embryonic lethality between implantation and placentation, complete penetrance 0.0124401819564126 0.122320361544552 1.40990550456933 0.347826086956522 21.1 21 1 fragile skeleton 0.0677644987668175 0.366443892787953 1.40990550456933 0.347826086956522 21.1 21 1 blistering 0.0677644987668175 0.366443892787953 1.40990550456933 0.347826086956522 21.1 21 1 bidirectional circling 0.0677644987668175 0.366443892787953 1.40990550456933 0.347826086956522 21.1 21 1 abnormal hepatocyte physiology 0.0677644987668175 0.366443892787953 1.40990550456933 0.347826086956522 21.1 21 1 abnormal neuromuscular synapse morphology 0.00214557533404568 0.0369350771172224 1.40745775195723 0.347222222222222 21.1 21 1 absent kidney 0.0104458978784344 0.10759491085965 1.40630880685359 0.346938775510204 21.1 21 1 abnormal craniofacial development 0.0104458978784344 0.10759491085965 1.40630880685359 0.346938775510204 21.1 21 1 abnormal snout morphology 0.00878004348897121 0.0962130316247396 1.40312711272044 0.346153846153846 21.1 21 1 absent corpus luteum 0.00878004348897121 0.0962130316247396 1.40312711272044 0.346153846153846 21.1 21 1 eyelids open at birth 0.00878004348897121 0.0962130316247396 1.40312711272044 0.346153846153846 21.1 21 1 kinked neural tube 0.00878004348897121 0.0962130316247396 1.40312711272044 0.346153846153846 21.1 21 1 decreased kidney weight 0.00878004348897121 0.0962130316247396 1.40312711272044 0.346153846153846 21.1 21 1 thick skin 0.0558106512541453 0.315385673484007 1.40312711272044 0.346153846153846 21.1 21 1 abnormal ocular fundus morphology 0.0558106512541453 0.315385673484007 1.40312711272044 0.346153846153846 21.1 21 1 anemia 3.18663578376069e-07 2.27241212841387e-05 1.40238823588383 0.345971563981043 21.1 21 1 abnormal head morphology 0.00738651986653423 0.0874950865143043 1.40029251249272 0.345454545454545 21.1 21 1 decreased circulating total protein level 0.00738651986653423 0.0874950865143043 1.40029251249272 0.345454545454545 21.1 21 1 abnormal blood vessel morphology 2.35594646026023e-05 0.00096866393717311 1.39775114677132 0.344827586206897 21.1 21 1 abnormal spermiogenesis 0.00621929203990986 0.0781337825720999 1.39775114677132 0.344827586206897 21.1 21 1 abnormal spinal nerve morphology 0.0461333033526183 0.292746408391933 1.39775114677132 0.344827586206897 21.1 21 1 decreased trophoblast giant cell number 0.0461333033526183 0.292746408391933 1.39775114677132 0.344827586206897 21.1 21 1 abnormal CD8-positive, alpha-beta T cell physiology 0.0461333033526183 0.292746408391933 1.39775114677132 0.344827586206897 21.1 21 1 oxidative stress 0.000790949658987888 0.0164643286755847 1.39619808994157 0.344444444444444 21.1 21 1 respiratory failure 1.70780659605974e-05 0.000751888302247541 1.3958998207491 0.344370860927152 21.1 21 1 decreased caudal vertebrae number 0.00441875183216728 0.06228308744546 1.39338317443766 0.34375 21.1 21 1 increased circulating follicle stimulating hormone level 0.0382493565899645 0.257996266668252 1.39338317443766 0.34375 21.1 21 1 abnormal heart atrium morphology 0.0382493565899645 0.257996266668252 1.39338317443766 0.34375 21.1 21 1 pancreatic islet hyperplasia 0.0382493565899645 0.257996266668252 1.39338317443766 0.34375 21.1 21 1 cleft palate 6.50797558966317e-05 0.00221761496976536 1.39241621873021 0.343511450381679 21.1 21 1 maternal effect 0.00372826718348654 0.0550389591627464 1.39149255954697 0.343283582089552 21.1 21 1 domed cranium 0.00314753813535356 0.0481815453027199 1.3897639973612 0.342857142857143 21.1 21 1 abnormal intestinal goblet cell morphology 0.0317936759701598 0.235413228674665 1.3897639973612 0.342857142857143 21.1 21 1 decreased triglyceride level 0.0317936759701598 0.235413228674665 1.3897639973612 0.342857142857143 21.1 21 1 decreased glycogen level 0.0317936759701598 0.235413228674665 1.3897639973612 0.342857142857143 21.1 21 1 decreased circulating thyroxine level 0.0317936759701598 0.235413228674665 1.3897639973612 0.342857142857143 21.1 21 1 abnormal fertility/fecundity 0.00265872100319119 0.0436539174616375 1.38817750877973 0.342465753424658 21.1 21 1 abnormal spermatogenesis 2.92520911515559e-06 0.000159404070880287 1.38787573106043 0.342391304347826 21.1 21 1 decreased hair follicle number 0.0264852956149053 0.208818297439229 1.38671626929681 0.342105263157895 21.1 21 1 Leydig cell hyperplasia 0.0221049519604411 0.187346057927078 1.38411455021745 0.341463414634146 21.1 21 1 hemopericardium 0.0221049519604411 0.187346057927078 1.38411455021745 0.341463414634146 21.1 21 1 abnormal cholesterol homeostasis 0.0221049519604411 0.187346057927078 1.38411455021745 0.341463414634146 21.1 21 1 thymus hypoplasia 5.78274567653942e-05 0.00201182935250235 1.38053247322414 0.340579710144928 21.1 21 1 enlarged heart 2.2709405000022e-07 1.68625805783745e-05 1.38027925743668 0.34051724137931 21.1 21 1 neuron degeneration 0.0154713801123117 0.146609744873811 1.37990751511041 0.340425531914894 21.1 21 1 kyphosis 3.02692309901368e-05 0.00118574349744827 1.37818263071652 0.34 21.1 21 1 increased bone mineral content 0.000362098611166552 0.00883059113016468 1.37595135824369 0.339449541284404 21.1 21 1 abnormal coat/hair pigmentation 0.000307276839239587 0.00804580144851024 1.37528728905535 0.339285714285714 21.1 21 1 enhanced long term potentiation 0.00914520961346915 0.0999943248945253 1.37528728905535 0.339285714285714 21.1 21 1 premature death 4.71890780973553e-23 3.35379519334775e-20 1.37469880497788 0.339140534262485 21.1 21 1 pericardial effusion 0.00647305070460234 0.0793187863433415 1.3729523361028 0.338709677419355 21.1 21 1 decreased grip strength 7.52285166667576e-07 4.86054377165089e-05 1.36966847532934 0.337899543378995 21.1 21 1 abnormal intestine morphology 0.00327216324569747 0.0497829117655808 1.36941835325568 0.337837837837838 21.1 21 1 small seminiferous tubules 0.00327216324569747 0.0497829117655808 1.36941835325568 0.337837837837838 21.1 21 1 decreased erythrocyte cell number 2.67718725503564e-05 0.00108284606453677 1.36837166406848 0.337579617834395 21.1 21 1 postnatal lethality 1.64934561259578e-05 0.000732633430595 1.36743847129917 0.337349397590361 21.1 21 1 insulin resistance 0.000170958364153632 0.00475149643387889 1.35115944187894 0.333333333333333 21.1 21 1 short snout 0.00063579492209077 0.0139342719709321 1.35115944187894 0.333333333333333 21.1 21 1 decreased circulating serum albumin level 0.00104505099908456 0.0207136602408195 1.35115944187894 0.333333333333333 21.1 21 1 increased susceptibility to pharmacologically induced seizures 0.00123414745778512 0.0235244582470535 1.35115944187894 0.333333333333333 21.1 21 1 abnormal digit morphology 0.00474252662600464 0.0646412875736249 1.35115944187894 0.333333333333333 21.1 21 1 neurodegeneration 0.0133717390462225 0.13022738343385 1.35115944187894 0.333333333333333 21.1 21 1 abnormal trophoblast layer morphology 0.0159474767987477 0.150258923540435 1.35115944187894 0.333333333333333 21.1 21 1 abnormal pancreas morphology 0.0272749629102246 0.214364834878938 1.35115944187894 0.333333333333333 21.1 21 1 heart right ventricle hypertrophy 0.0393511141624442 0.258274133190185 1.35115944187894 0.333333333333333 21.1 21 1 reduced long term depression 0.0393511141624442 0.258274133190185 1.35115944187894 0.333333333333333 21.1 21 1 renal hypoplasia 0.0393511141624442 0.258274133190185 1.35115944187894 0.333333333333333 21.1 21 1 abnormal tooth development 0.0474302564909633 0.294969584317246 1.35115944187894 0.333333333333333 21.1 21 1 decreased systemic arterial blood pressure 0.0474302564909633 0.294969584317246 1.35115944187894 0.333333333333333 21.1 21 1 increased cardiomyocyte apoptosis 0.0474302564909633 0.294969584317246 1.35115944187894 0.333333333333333 21.1 21 1 abnormal locomotor coordination 0.0474302564909633 0.294969584317246 1.35115944187894 0.333333333333333 21.1 21 1 myeloid hyperplasia 0.0474302564909633 0.294969584317246 1.35115944187894 0.333333333333333 21.1 21 1 abnormal response to new environment 0.0573307945219304 0.319754151061215 1.35115944187894 0.333333333333333 21.1 21 1 abnormal lactation 0.0573307945219304 0.319754151061215 1.35115944187894 0.333333333333333 21.1 21 1 emphysema 0.0573307945219304 0.319754151061215 1.35115944187894 0.333333333333333 21.1 21 1 abnormal skin appearance 0.0695333684721497 0.369112065461263 1.35115944187894 0.333333333333333 21.1 21 1 abnormal adrenal gland morphology 0.0846816273807649 0.417119897246837 1.35115944187894 0.333333333333333 21.1 21 1 decreased body height 0.0846816273807649 0.417119897246837 1.35115944187894 0.333333333333333 21.1 21 1 curly vibrissae 0.0846816273807649 0.417119897246837 1.35115944187894 0.333333333333333 21.1 21 1 abnormal vasodilation 0.0846816273807649 0.417119897246837 1.35115944187894 0.333333333333333 21.1 21 1 apnea 0.0846816273807649 0.417119897246837 1.35115944187894 0.333333333333333 21.1 21 1 abnormal tumor morphology 0.0846816273807649 0.417119897246837 1.35115944187894 0.333333333333333 21.1 21 1 increased body temperature 0.0846816273807649 0.417119897246837 1.35115944187894 0.333333333333333 21.1 21 1 abnormal salivary gland morphology 0.1036603982333 0.444203205586485 1.35115944187894 0.333333333333333 21.1 21 1 trunk curl 0.1036603982333 0.444203205586485 1.35115944187894 0.333333333333333 21.1 21 1 abnormal hematopoietic system physiology 0.1036603982333 0.444203205586485 1.35115944187894 0.333333333333333 21.1 21 1 abnormal associative learning 0.1036603982333 0.444203205586485 1.35115944187894 0.333333333333333 21.1 21 1 abnormal erythrocyte physiology 0.1036603982333 0.444203205586485 1.35115944187894 0.333333333333333 21.1 21 1 abnormal megakaryocyte differentiation 0.127729476250314 0.515790701578988 1.35115944187894 0.333333333333333 21.1 21 1 abnormal heart shape 0.127729476250314 0.515790701578988 1.35115944187894 0.333333333333333 21.1 21 1 underdeveloped hair follicles 0.127729476250314 0.515790701578988 1.35115944187894 0.333333333333333 21.1 21 1 delayed kidney development 0.127729476250314 0.515790701578988 1.35115944187894 0.333333333333333 21.1 21 1 decreased cellular sensitivity to gamma-irradiation 0.127729476250314 0.515790701578988 1.35115944187894 0.333333333333333 21.1 21 1 increased circulating glycerol level 0.127729476250314 0.515790701578988 1.35115944187894 0.333333333333333 21.1 21 1 decreased activity of thyroid 0.127729476250314 0.515790701578988 1.35115944187894 0.333333333333333 21.1 21 1 absent ureter 0.127729476250314 0.515790701578988 1.35115944187894 0.333333333333333 21.1 21 1 jerky movement 0.127729476250314 0.515790701578988 1.35115944187894 0.333333333333333 21.1 21 1 abnormal sperm axoneme morphology 0.127729476250314 0.515790701578988 1.35115944187894 0.333333333333333 21.1 21 1 atrioventricular block 0.127729476250314 0.515790701578988 1.35115944187894 0.333333333333333 21.1 21 1 abnormal fontanelle morphology 0.158771657303645 0.564147358908817 1.35115944187894 0.333333333333333 21.1 21 1 abnormal enteric neuron morphology 0.158771657303645 0.564147358908817 1.35115944187894 0.333333333333333 21.1 21 1 audiogenic seizures 0.158771657303645 0.564147358908817 1.35115944187894 0.333333333333333 21.1 21 1 abnormal seizure response to electrical stimulation 0.158771657303645 0.564147358908817 1.35115944187894 0.333333333333333 21.1 21 1 decreased aggression towards males 0.158771657303645 0.564147358908817 1.35115944187894 0.333333333333333 21.1 21 1 abnormal rostral migratory stream morphology 0.158771657303645 0.564147358908817 1.35115944187894 0.333333333333333 21.1 21 1 abnormal trophectoderm morphology 0.158771657303645 0.564147358908817 1.35115944187894 0.333333333333333 21.1 21 1 abnormal neurotransmitter secretion 0.158771657303645 0.564147358908817 1.35115944187894 0.333333333333333 21.1 21 1 decreased trabecular bone mass 0.158771657303645 0.564147358908817 1.35115944187894 0.333333333333333 21.1 21 1 decreased brown adipose tissue mass 0.158771657303645 0.564147358908817 1.35115944187894 0.333333333333333 21.1 21 1 abnormal heart ventricle morphology 0.00337690580123349 0.0512198364668799 1.35115944187894 0.333333333333333 21.1 21 1 abnormal lens fiber morphology 0.0327271649476291 0.238568691899778 1.35115944187894 0.333333333333333 21.1 21 1 impaired macrophage chemotaxis 0.0327271649476291 0.238568691899778 1.35115944187894 0.333333333333333 21.1 21 1 abnormal neuron differentiation 0.000653409806470512 0.0142575166104859 1.33909551829074 0.330357142857143 21.1 21 1 decreased circulating glucose level 1.33170779250171e-07 1.05162639169778e-05 1.33663084572971 0.329749103942652 21.1 21 1 impaired fertilization 0.00683827216871316 0.0825737962120097 1.33185716413781 0.328571428571429 21.1 21 1 decreased cardiac muscle contractility 0.00129577574784091 0.0245113473213253 1.32517560645819 0.326923076923077 21.1 21 1 decreased circulating creatinine level 0.0232117985292295 0.195726606242232 1.32358475939162 0.326530612244898 21.1 21 1 abnormal left-right axis patterning 0.0332821492315289 0.241368356307371 1.31973712927711 0.325581395348837 21.1 21 1 decreased anxiety-related response 0.000578533554432132 0.0128491269343744 1.31820433354043 0.32520325203252 21.1 21 1 abnormal angiogenesis 0.00695884749186501 0.0834223283663336 1.31464161912546 0.324324324324324 21.1 21 1 increased granulocyte number 0.00695884749186501 0.0834223283663336 1.31464161912546 0.324324324324324 21.1 21 1 abnormal vocalization 0.0480818821001341 0.294969584317246 1.31464161912546 0.324324324324324 21.1 21 1 decreased width of hypertrophic chondrocyte zone 0.0480818821001341 0.294969584317246 1.31464161912546 0.324324324324324 21.1 21 1 abnormal chromosome morphology 0.0480818821001341 0.294969584317246 1.31464161912546 0.324324324324324 21.1 21 1 respiratory distress 6.1438483569695e-05 0.00212261427610578 1.31210859095758 0.323699421965318 21.1 21 1 abnormal retinal photoreceptor morphology 0.0579979499589899 0.321599608652584 1.31141945829427 0.323529411764706 21.1 21 1 abnormal oocyte morphology 0.0579979499589899 0.321599608652584 1.31141945829427 0.323529411764706 21.1 21 1 abnormal endoderm development 0.0579979499589899 0.321599608652584 1.31141945829427 0.323529411764706 21.1 21 1 decreased monocyte cell number 0.0116522566351048 0.115780148601801 1.30958530520574 0.323076923076923 21.1 21 1 abnormal capillary morphology 0.0701637014158926 0.369380332850863 1.30757365343123 0.32258064516129 21.1 21 1 inner cell mass degeneration 0.0701637014158926 0.369380332850863 1.30757365343123 0.32258064516129 21.1 21 1 decreased neuronal precursor cell number 0.0701637014158926 0.369380332850863 1.30757365343123 0.32258064516129 21.1 21 1 myoclonus 0.0851773082888207 0.41831896222792 1.30290374752612 0.321428571428571 21.1 21 1 abnormal jaw morphology 0.0851773082888207 0.41831896222792 1.30290374752612 0.321428571428571 21.1 21 1 premature aging 0.0851773082888207 0.41831896222792 1.30290374752612 0.321428571428571 21.1 21 1 abnormal pancreatic islet morphology 0.0234633048375427 0.197512591483545 1.30017229312879 0.320754716981132 21.1 21 1 decreased lymphocyte cell number 0.000701931093988043 0.0149875845175559 1.29837977618055 0.3203125 21.1 21 1 abnormal primitive streak morphology 0.103840869969263 0.444203205586485 1.29711306420378 0.32 21.1 21 1 abnormal egg cylinder morphology 0.103840869969263 0.444203205586485 1.29711306420378 0.32 21.1 21 1 decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 0.103840869969263 0.444203205586485 1.29711306420378 0.32 21.1 21 1 increased liver glycogen level 0.103840869969263 0.444203205586485 1.29711306420378 0.32 21.1 21 1 abnormal myocardial fiber morphology 0.0030670441049925 0.0476829513198053 1.29544152674991 0.319587628865979 21.1 21 1 microcephaly 0.0117614467603612 0.116131998120731 1.29241337918855 0.318840579710145 21.1 21 1 small spleen 0.00428436155844841 0.0619613335851187 1.29176781806009 0.318681318681319 21.1 21 1 abnormal vascular development 0.0139736532111301 0.133433636708967 1.28974310361172 0.318181818181818 21.1 21 1 abnormal circadian rhythm 0.0401900086602991 0.262395397749328 1.28974310361172 0.318181818181818 21.1 21 1 embryonic lethality, incomplete penetrance 0.0401900086602991 0.262395397749328 1.28974310361172 0.318181818181818 21.1 21 1 abnormal lysosome physiology 0.127257757459636 0.515790701578988 1.28974310361172 0.318181818181818 21.1 21 1 decreased cardiac output 0.127257757459636 0.515790701578988 1.28974310361172 0.318181818181818 21.1 21 1 abnormal retinal layer morphology 0.127257757459636 0.515790701578988 1.28974310361172 0.318181818181818 21.1 21 1 abnormal limb posture 0.127257757459636 0.515790701578988 1.28974310361172 0.318181818181818 21.1 21 1 increased circulating creatine kinase level 0.127257757459636 0.515790701578988 1.28974310361172 0.318181818181818 21.1 21 1 rough coat 0.127257757459636 0.515790701578988 1.28974310361172 0.318181818181818 21.1 21 1 abnormal hair follicle morphology 0.0166158389808243 0.151952412862406 1.28681851607518 0.317460317460317 21.1 21 1 cachexia 0.0026187451409472 0.0432832461003731 1.28619985332707 0.317307692307692 21.1 21 1 hunched posture 0.00840599487116322 0.0941887938829662 1.28274630558127 0.316455696202532 21.1 21 1 increased hepatocellular carcinoma incidence 0.0235601519831726 0.197992831277506 1.28004578704321 0.315789473684211 21.1 21 1 abnormal reproductive system physiology 0.0580495374010091 0.321599608652584 1.28004578704321 0.315789473684211 21.1 21 1 abnormal retinal outer nuclear layer morphology 0.0580495374010091 0.321599608652584 1.28004578704321 0.315789473684211 21.1 21 1 irregular coat pigmentation 0.156997783020465 0.564147358908817 1.28004578704321 0.315789473684211 21.1 21 1 enlarged adrenal glands 0.156997783020465 0.564147358908817 1.28004578704321 0.315789473684211 21.1 21 1 thin dermal layer 0.156997783020465 0.564147358908817 1.28004578704321 0.315789473684211 21.1 21 1 stereotypic behavior 0.156997783020465 0.564147358908817 1.28004578704321 0.315789473684211 21.1 21 1 abnormal long term depression 0.156997783020465 0.564147358908817 1.28004578704321 0.315789473684211 21.1 21 1 abnormal neurotransmitter level 0.156997783020465 0.564147358908817 1.28004578704321 0.315789473684211 21.1 21 1 abnormal metatarsal bone morphology 0.156997783020465 0.564147358908817 1.28004578704321 0.315789473684211 21.1 21 1 abnormal blastocyst morphology 0.156997783020465 0.564147358908817 1.28004578704321 0.315789473684211 21.1 21 1 decreased eye pigmentation 0.156997783020465 0.564147358908817 1.28004578704321 0.315789473684211 21.1 21 1 thin interventricular septum 0.156997783020465 0.564147358908817 1.28004578704321 0.315789473684211 21.1 21 1 perinatal lethality, complete penetrance 3.4810262358593e-05 0.00132497507585456 1.27503778318154 0.314553990610329 21.1 21 1 abnormal retina morphology 4.08099187588959e-05 0.00151514437183214 1.27395033091443 0.314285714285714 21.1 21 1 abnormal dermal layer morphology 0.0700082422038701 0.369380332850863 1.27395033091443 0.314285714285714 21.1 21 1 abnormal midbrain development 0.0700082422038701 0.369380332850863 1.27395033091443 0.314285714285714 21.1 21 1 increased oxygen consumption 0.00712241344537239 0.0851779011796337 1.27260366037435 0.313953488372093 21.1 21 1 kinked tail 0.00366381803732056 0.0542484962371125 1.27167947470959 0.313725490196078 21.1 21 1 small lung 0.0335557959375303 0.242645472077345 1.27167947470959 0.313725490196078 21.1 21 1 decreased white adipose tissue amount 0.0166460432180927 0.151952412862406 1.27049320654289 0.313432835820896 21.1 21 1 abnormal lipid level 0.00842720052398917 0.0942142081052722 1.2697642947778 0.313253012048193 21.1 21 1 abnormal glucose homeostasis 0.000145425875568106 0.00408753520311483 1.26949595912802 0.313186813186813 21.1 21 1 abnormal retinal pigment epithelium morphology 0.00997595227624716 0.104265467593129 1.26671197676151 0.3125 21.1 21 1 reduced long term potentiation 0.00263930021819968 0.0434785383627265 1.26671197676151 0.3125 21.1 21 1 thymus atrophy 0.0401258525758135 0.262395397749328 1.26671197676151 0.3125 21.1 21 1 polydipsia 0.0846702217913143 0.417119897246837 1.26671197676151 0.3125 21.1 21 1 failure of primitive streak formation 0.0846702217913143 0.417119897246837 1.26671197676151 0.3125 21.1 21 1 increased dopamine level 0.0846702217913143 0.417119897246837 1.26671197676151 0.3125 21.1 21 1 abnormal tympanic ring morphology 0.195398880535138 0.564147358908817 1.26671197676151 0.3125 21.1 21 1 abnormal pituitary gland morphology 0.195398880535138 0.564147358908817 1.26671197676151 0.3125 21.1 21 1 intraventricular hemorrhage 0.195398880535138 0.564147358908817 1.26671197676151 0.3125 21.1 21 1 abnormal meiosis 0.195398880535138 0.564147358908817 1.26671197676151 0.3125 21.1 21 1 abnormal pulmonary elastic fiber morphology 0.195398880535138 0.564147358908817 1.26671197676151 0.3125 21.1 21 1 increased cochlear outer hair cell number 0.195398880535138 0.564147358908817 1.26671197676151 0.3125 21.1 21 1 loose skin 0.195398880535138 0.564147358908817 1.26671197676151 0.3125 21.1 21 1 impaired somite development 0.195398880535138 0.564147358908817 1.26671197676151 0.3125 21.1 21 1 increased heart left ventricle size 0.195398880535138 0.564147358908817 1.26671197676151 0.3125 21.1 21 1 embryonic lethality between somite formation and embryo turning, incomplete penetrance 0.195398880535138 0.564147358908817 1.26671197676151 0.3125 21.1 21 1 decreased midbrain size 0.195398880535138 0.564147358908817 1.26671197676151 0.3125 21.1 21 1 decreased adipocyte glucose uptake 0.195398880535138 0.564147358908817 1.26671197676151 0.3125 21.1 21 1 lethargy 0.00602906565291544 0.0768600073129678 1.26398786498353 0.311827956989247 21.1 21 1 neonatal lethality, complete penetrance 4.74332681619311e-09 5.48791881640947e-07 1.26226737333427 0.31140350877193 21.1 21 1 irregular heartbeat 0.0480560550420922 0.294969584317246 1.26108214575368 0.311111111111111 21.1 21 1 abnormal ectoderm development 0.0480560550420922 0.294969584317246 1.26108214575368 0.311111111111111 21.1 21 1 abnormal metabolism 0.0480560550420922 0.294969584317246 1.26108214575368 0.311111111111111 21.1 21 1 lordosis 0.102747110510112 0.444106754811299 1.25797603209419 0.310344827586207 21.1 21 1 decreased retinal photoreceptor cell number 0.102747110510112 0.444106754811299 1.25797603209419 0.310344827586207 21.1 21 1 atelectasis 0.0166043059093465 0.151952412862406 1.25600736850718 0.309859154929577 21.1 21 1 increased circulating free fatty acid level 0.0166043059093465 0.151952412862406 1.25600736850718 0.309859154929577 21.1 21 1 skin edema 0.0576533937965578 0.321193319303332 1.2546480531733 0.30952380952381 21.1 21 1 abnormal learning/memory/conditioning 0.0333863004482399 0.241771244148462 1.25289330065138 0.309090909090909 21.1 21 1 female infertility 1.16615984973711e-05 0.000542209836676835 1.24956850639932 0.308270676691729 21.1 21 1 increased insulin sensitivity 0.00116560348905283 0.0223033744539917 1.24722410019595 0.307692307692308 21.1 21 1 decreased neutrophil cell number 0.00309773170230531 0.0480100162584702 1.24722410019595 0.307692307692308 21.1 21 1 abnormal B cell differentiation 0.00838466289536483 0.0941618462854177 1.24722410019595 0.307692307692308 21.1 21 1 absent gastric milk in neonates 0.0139363980091862 0.133333807876349 1.24722410019595 0.307692307692308 21.1 21 1 abnormal female meiosis 0.0398344601101169 0.261102027731003 1.24722410019595 0.307692307692308 21.1 21 1 increased hepatocyte apoptosis 0.0693039251580668 0.369112065461263 1.24722410019595 0.307692307692308 21.1 21 1 abnormal response to injury 0.0693039251580668 0.369112065461263 1.24722410019595 0.307692307692308 21.1 21 1 abnormal xiphoid process morphology 0.125187633842648 0.513009699988737 1.24722410019595 0.307692307692308 21.1 21 1 abnormal ureter morphology 0.125187633842648 0.513009699988737 1.24722410019595 0.307692307692308 21.1 21 1 heart inflammation 0.125187633842648 0.513009699988737 1.24722410019595 0.307692307692308 21.1 21 1 abnormal tectorial membrane morphology 0.125187633842648 0.513009699988737 1.24722410019595 0.307692307692308 21.1 21 1 microphthalmia 0.000842872509076308 0.017045897287214 1.24518615231981 0.30718954248366 21.1 21 1 teratozoospermia 0.00990242812928972 0.103906060943932 1.2436808499113 0.306818181818182 21.1 21 1 delayed bone ossification 0.0165022042958303 0.151753172591046 1.24306668652863 0.306666666666667 21.1 21 1 decreased leukocyte cell number 0.00160720252013621 0.0284549200629098 1.24267218742151 0.306569343065693 21.1 21 1 impaired glucose tolerance 2.97846971640278e-05 0.00117602276500824 1.24219497075967 0.306451612903226 21.1 21 1 increased circulating LDL cholesterol level 0.0475879352434242 0.294969584317246 1.24086071192964 0.306122448979592 21.1 21 1 cardiac fibrosis 0.0116992404068351 0.115943667378496 1.23988748784185 0.305882352941176 21.1 21 1 narrow eye opening 0.0834973785420975 0.415399458246935 1.23856282172236 0.305555555555556 21.1 21 1 impaired righting response 0.00832818908543029 0.0937392323529767 1.23737759414177 0.305263157894737 21.1 21 1 increased B cell proliferation 0.0330684960791975 0.24052012864621 1.23665440443157 0.305084745762712 21.1 21 1 sparse hair 0.0138274857172897 0.132546707983653 1.23581656269415 0.304878048780488 21.1 21 1 abnormal lens morphology 0.00260390127128553 0.0431813627488184 1.23504417734247 0.3046875 21.1 21 1 abnormal spleen morphology 0.000515008924805267 0.0118618953745657 1.234680179648 0.304597701149425 21.1 21 1 decreased bone mineral density 2.14848407888575e-05 0.000905822736648864 1.23432986607738 0.304511278195489 21.1 21 1 decreased T cell number 0.00083351004956871 0.0169717815486572 1.23366731649816 0.304347826086957 21.1 21 1 abnormal nasal cavity morphology 0.153286058137744 0.564147358908817 1.23366731649816 0.304347826086957 21.1 21 1 abnormal basicranium morphology 0.153286058137744 0.564147358908817 1.23366731649816 0.304347826086957 21.1 21 1 abnormal hematopoietic stem cell physiology 0.153286058137744 0.564147358908817 1.23366731649816 0.304347826086957 21.1 21 1 increased circulating triglyceride level 0.00158575966811202 0.0281755512459188 1.23002100915876 0.303448275862069 21.1 21 1 postnatal lethality, complete penetrance 4.88940215260539e-07 3.37844107072387e-05 1.22864498471375 0.303108808290155 21.1 21 1 belly spot 0.100861511052336 0.441505332994711 1.22832676534449 0.303030303030303 21.1 21 1 abnormal epidermis stratum basale morphology 0.100861511052336 0.441505332994711 1.22832676534449 0.303030303030303 21.1 21 1 dilated heart atrium 0.100861511052336 0.441505332994711 1.22832676534449 0.303030303030303 21.1 21 1 head tossing 0.100861511052336 0.441505332994711 1.22832676534449 0.303030303030303 21.1 21 1 short tail 0.0161551948523328 0.150258923540435 1.22092720651712 0.301204819277108 21.1 21 1 hypoglycemia 0.0114588767735392 0.11470404818583 1.22040207653582 0.301075268817204 21.1 21 1 increased spleen weight 0.00583015323778463 0.0763289798894172 1.21963064665179 0.300884955752212 21.1 21 1 abnormal social investigation 0.0190812559288239 0.165670590306979 1.21604349769105 0.3 21.1 21 1 abnormal dopamine level 0.188861496217332 0.564147358908817 1.21604349769105 0.3 21.1 21 1 abnormal hyoid bone morphology 0.188861496217332 0.564147358908817 1.21604349769105 0.3 21.1 21 1 decreased skin tensile strength 0.188861496217332 0.564147358908817 1.21604349769105 0.3 21.1 21 1 abnormal lens epithelium morphology 0.188861496217332 0.564147358908817 1.21604349769105 0.3 21.1 21 1 abnormal optic stalk morphology 0.188861496217332 0.564147358908817 1.21604349769105 0.3 21.1 21 1 enhanced behavioral response to xenobiotic 0.188861496217332 0.564147358908817 1.21604349769105 0.3 21.1 21 1 abnormal lipid homeostasis 0.00351756495435053 0.0523948672092631 1.21604349769105 0.3 21.1 21 1 decreased heart rate 0.00960340929736181 0.103906060943932 1.21604349769105 0.3 21.1 21 1 epidermal hyperplasia 0.0387654074766465 0.257996266668252 1.21604349769105 0.3 21.1 21 1 intracranial hemorrhage 0.0387654074766465 0.257996266668252 1.21604349769105 0.3 21.1 21 1 gastrointestinal hemorrhage 0.122211245933618 0.506245585778309 1.21604349769105 0.3 21.1 21 1 infertility 0.00805382873178138 0.0914789907319917 1.21225520019045 0.299065420560748 21.1 21 1 increased total body fat amount 0.00347239191034309 0.0522920450473693 1.20999353004084 0.298507462686567 21.1 21 1 increased macrophage cell number 0.0460856090898191 0.292746408391933 1.20893213220747 0.298245614035088 21.1 21 1 decreased hemoglobin content 0.00292376199239059 0.0460307465574152 1.20741907572161 0.297872340425532 21.1 21 1 increased cellular sensitivity to gamma-irradiation 0.0668546784678349 0.363102647792007 1.20741907572161 0.297872340425532 21.1 21 1 abnormal innervation 0.0668546784678349 0.363102647792007 1.20741907572161 0.297872340425532 21.1 21 1 cataract 0.00567508196053179 0.0746918855916551 1.20599355142914 0.297520661157025 21.1 21 1 impaired skeletal muscle contractility 0.098480857806005 0.441505332994711 1.205088150865 0.297297297297297 21.1 21 1 weight loss 0.00108111356411234 0.0212590513101143 1.20446213104637 0.297142857142857 21.1 21 1 abnormal tooth morphology 0.0380601244565527 0.257996266668252 1.20337637792343 0.296875 21.1 21 1 small ovary 0.0156685851289709 0.147915011416756 1.2026803823318 0.296703296703297 21.1 21 1 abnormal locomotor activation 0.0156685851289709 0.147915011416756 1.2026803823318 0.296703296703297 21.1 21 1 increased leukocyte cell number 0.00288123936521394 0.045667540335513 1.20206598622333 0.296551724137931 21.1 21 1 abnormal chondrocyte morphology 0.0548355242506779 0.315385673484007 1.2010306150035 0.296296296296296 21.1 21 1 diluted coat color 0.0548355242506779 0.315385673484007 1.2010306150035 0.296296296296296 21.1 21 1 rectal prolapse 0.148621008735489 0.564147358908817 1.2010306150035 0.296296296296296 21.1 21 1 abnormal trigeminal nerve morphology 0.148621008735489 0.564147358908817 1.2010306150035 0.296296296296296 21.1 21 1 thin epidermis 0.148621008735489 0.564147358908817 1.2010306150035 0.296296296296296 21.1 21 1 abnormal brain commissure morphology 0.148621008735489 0.564147358908817 1.2010306150035 0.296296296296296 21.1 21 1 thick interventricular septum 0.148621008735489 0.564147358908817 1.2010306150035 0.296296296296296 21.1 21 1 cardiac hypertrophy 0.0130864337282964 0.12790767740329 1.19949868819865 0.295918367346939 21.1 21 1 abnormal skeletal muscle fiber morphology 0.0315113158713795 0.235413228674665 1.19891612448413 0.295774647887324 21.1 21 1 omphalocele 0.0799663745431575 0.411835106989864 1.19761859621088 0.295454545454545 21.1 21 1 renal interstitial fibrosis 0.0799663745431575 0.411835106989864 1.19761859621088 0.295454545454545 21.1 21 1 abnormal photoreceptor outer segment morphology 0.0799663745431575 0.411835106989864 1.19761859621088 0.295454545454545 21.1 21 1 enlarged spleen 4.83115596246526e-05 0.00174166673284526 1.19633908916365 0.295138888888889 21.1 21 1 increased osteoclast cell number 0.0451430130737527 0.287931397489641 1.19610835838464 0.295081967213115 21.1 21 1 lung hemorrhage 0.118721328174564 0.493432420775653 1.19219950754024 0.294117647058824 21.1 21 1 thin skin 0.118721328174564 0.493432420775653 1.19219950754024 0.294117647058824 21.1 21 1 impaired synaptic plasticity 0.118721328174564 0.493432420775653 1.19219950754024 0.294117647058824 21.1 21 1 abnormal vagus nerve morphology 0.234573921701298 0.644941332728007 1.19219950754024 0.294117647058824 21.1 21 1 abnormal cranial suture morphology 0.234573921701298 0.644941332728007 1.19219950754024 0.294117647058824 21.1 21 1 abnormal duodenum morphology 0.234573921701298 0.644941332728007 1.19219950754024 0.294117647058824 21.1 21 1 abnormal involuntary movement 0.234573921701298 0.644941332728007 1.19219950754024 0.294117647058824 21.1 21 1 increased trabecular bone mass 0.234573921701298 0.644941332728007 1.19219950754024 0.294117647058824 21.1 21 1 delayed heart development 0.234573921701298 0.644941332728007 1.19219950754024 0.294117647058824 21.1 21 1 abnormal neurocranium morphology 0.0308604165952557 0.234397820704423 1.18902030885347 0.293333333333333 21.1 21 1 decreased bone mineral content 0.000620131038489825 0.0136511146747207 1.18876047049926 0.293269230769231 21.1 21 1 dermatitis 0.0535788133643302 0.315385673484007 1.18808847475562 0.293103448275862 21.1 21 1 abnormal enzyme/coenzyme activity 0.00273959159436486 0.0448337769143591 1.18764333107831 0.292993630573248 21.1 21 1 deafness 0.0150890818231846 0.143533808929911 1.18738253983301 0.292929292929293 21.1 21 1 increased tumor growth/size 0.0957951942690533 0.441505332994711 1.18638390018639 0.292682926829268 21.1 21 1 palatal shelves fail to meet at midline 0.0957951942690533 0.441505332994711 1.18638390018639 0.292682926829268 21.1 21 1 decreased rib number 0.0212832585757271 0.183826755927504 1.18416220748941 0.292134831460674 21.1 21 1 abnormal heart left ventricle morphology 0.0364361119760804 0.257988188473751 1.18226451164407 0.291666666666667 21.1 21 1 abnormal nursing 0.181534941390617 0.564147358908817 1.18226451164407 0.291666666666667 21.1 21 1 increased stereotypic behavior 0.181534941390617 0.564147358908817 1.18226451164407 0.291666666666667 21.1 21 1 abnormal startle reflex 0.181534941390617 0.564147358908817 1.18226451164407 0.291666666666667 21.1 21 1 hemolytic anemia 0.181534941390617 0.564147358908817 1.18226451164407 0.291666666666667 21.1 21 1 blindness 0.181534941390617 0.564147358908817 1.18226451164407 0.291666666666667 21.1 21 1 prolonged QT interval 0.181534941390617 0.564147358908817 1.18226451164407 0.291666666666667 21.1 21 1 decreased ovulation rate 0.181534941390617 0.564147358908817 1.18226451164407 0.291666666666667 21.1 21 1 increased hemangiosarcoma incidence 0.181534941390617 0.564147358908817 1.18226451164407 0.291666666666667 21.1 21 1 abnormal osteoblast morphology 0.181534941390617 0.564147358908817 1.18226451164407 0.291666666666667 21.1 21 1 increased circulating total protein level 0.181534941390617 0.564147358908817 1.18226451164407 0.291666666666667 21.1 21 1 abnormal lung saccule morphology 0.181534941390617 0.564147358908817 1.18226451164407 0.291666666666667 21.1 21 1 decreased circulating calcium level 0.0636352058106526 0.349817844097234 1.17919369473071 0.290909090909091 21.1 21 1 abnormal definitive hematopoiesis 0.0208116044882862 0.180379324615373 1.17681628808811 0.290322580645161 21.1 21 1 abnormal cranial ganglia morphology 0.143503423236324 0.562962228636371 1.17681628808811 0.290322580645161 21.1 21 1 abnormal nose morphology 0.143503423236324 0.562962228636371 1.17681628808811 0.290322580645161 21.1 21 1 abnormal mitochondrial ATP synthesis coupled electron transport 0.143503423236324 0.562962228636371 1.17681628808811 0.290322580645161 21.1 21 1 abnormal sternum morphology 0.0430320843800513 0.275527181197883 1.17492125380777 0.289855072463768 21.1 21 1 abnormal coat appearance 0.0430320843800513 0.275527181197883 1.17492125380777 0.289855072463768 21.1 21 1 decreased spleen weight 0.0430320843800513 0.275527181197883 1.17492125380777 0.289855072463768 21.1 21 1 increased circulating cholesterol level 0.00217365610926353 0.0372894453227105 1.17458746936067 0.289772727272727 21.1 21 1 persistence of hyaloid vascular system 0.114952877230263 0.488795354034664 1.17337530478961 0.289473684210526 21.1 21 1 increased grooming behavior 0.114952877230263 0.488795354034664 1.17337530478961 0.289473684210526 21.1 21 1 impaired branching involved in ureteric bud morphogenesis 0.114952877230263 0.488795354034664 1.17337530478961 0.289473684210526 21.1 21 1 hyporesponsive to tactile stimuli 0.114952877230263 0.488795354034664 1.17337530478961 0.289473684210526 21.1 21 1 decreased total retina thickness 0.114952877230263 0.488795354034664 1.17337530478961 0.289473684210526 21.1 21 1 decreased insulin secretion 0.0244421924327012 0.204026690189075 1.17100484962842 0.288888888888889 21.1 21 1 abnormal skin condition 0.0756353056319028 0.396507529524464 1.1692725939337 0.288461538461538 21.1 21 1 increased hemoglobin content 0.0618806084559315 0.340638922076875 1.16795138196315 0.288135593220339 21.1 21 1 increased anxiety-related response 0.00690858787822826 0.0832208830367689 1.16646858291707 0.287769784172662 21.1 21 1 decreased hematocrit 0.00579130075879689 0.0760203727572943 1.16606910737498 0.287671232876712 21.1 21 1 cleft secondary palate 0.0238357470692776 0.199524978015004 1.16429696587441 0.287234042553192 21.1 21 1 no abnormal phenotype detected 3.65332117063175e-20 2.01947475821033e-17 1.16347677588884 0.287031700288184 21.1 21 1 abnormal respiratory system physiology 0.0899697577424113 0.440984773170932 1.15813666446766 0.285714285714286 21.1 21 1 thick pulmonary interalveolar septum 0.138206562562842 0.554945640637723 1.15813666446766 0.285714285714286 21.1 21 1 shortened head 0.173998488914157 0.564147358908817 1.15813666446766 0.285714285714286 21.1 21 1 increased circulating luteinizing hormone level 0.173998488914157 0.564147358908817 1.15813666446766 0.285714285714286 21.1 21 1 abnormal ovulation 0.173998488914157 0.564147358908817 1.15813666446766 0.285714285714286 21.1 21 1 abnormal respiration 0.173998488914157 0.564147358908817 1.15813666446766 0.285714285714286 21.1 21 1 abnormal hormone level 0.173998488914157 0.564147358908817 1.15813666446766 0.285714285714286 21.1 21 1 decreased circulating progesterone level 0.173998488914157 0.564147358908817 1.15813666446766 0.285714285714286 21.1 21 1 increased incidence of induced tumors 0.222941935410944 0.619629122161703 1.15813666446766 0.285714285714286 21.1 21 1 liver degeneration 0.222941935410944 0.619629122161703 1.15813666446766 0.285714285714286 21.1 21 1 dry skin 0.222941935410944 0.619629122161703 1.15813666446766 0.285714285714286 21.1 21 1 abnormal clavicle morphology 0.222941935410944 0.619629122161703 1.15813666446766 0.285714285714286 21.1 21 1 vascular ring 0.222941935410944 0.619629122161703 1.15813666446766 0.285714285714286 21.1 21 1 alopecia 0.0271899787225841 0.214035038203886 1.15204120833889 0.284210526315789 21.1 21 1 decreased circulating cholesterol level 0.0031129598356707 0.0480260021133318 1.15180804881484 0.284153005464481 21.1 21 1 abnormal cranium morphology 0.0106584826397035 0.109557750273812 1.1494938535388 0.283582089552239 21.1 21 1 decreased compact bone thickness 0.0582514656185893 0.32166559455397 1.1494938535388 0.283582089552239 21.1 21 1 abnormal placenta development 0.0869727110367204 0.426715224267933 1.14721084687835 0.283018867924528 21.1 21 1 increased rib number 0.046497301851024 0.2943054411054 1.14328875851295 0.282051282051282 21.1 21 1 abnormal cornea morphology 0.046497301851024 0.2943054411054 1.14328875851295 0.282051282051282 21.1 21 1 decreased trabecular bone volume 0.132886394115768 0.535609581440093 1.14328875851295 0.282051282051282 21.1 21 1 decreased circulating LDL cholesterol level 0.0686932570681708 0.369112065461263 1.14004077908536 0.28125 21.1 21 1 abnormal vertebral body morphology 0.166525110758284 0.564147358908817 1.14004077908536 0.28125 21.1 21 1 neonatal lethality 0.166525110758284 0.564147358908817 1.14004077908536 0.28125 21.1 21 1 increased startle reflex 0.0372644976682382 0.257996266668252 1.13861750720136 0.280898876404494 21.1 21 1 increased monocyte cell number 0.0299638421630352 0.230582364444644 1.13497393117831 0.28 21.1 21 1 abnormal limb morphology 0.0545998933940079 0.315385673484007 1.13497393117831 0.28 21.1 21 1 increased circulating chloride level 0.103192191293256 0.444203205586485 1.13497393117831 0.28 21.1 21 1 testicular atrophy 0.103192191293256 0.444203205586485 1.13497393117831 0.28 21.1 21 1 decreased oocyte number 0.103192191293256 0.444203205586485 1.13497393117831 0.28 21.1 21 1 mandible hypoplasia 0.211749302498922 0.593160349060888 1.13497393117831 0.28 21.1 21 1 abnormal thyroid gland morphology 0.211749302498922 0.593160349060888 1.13497393117831 0.28 21.1 21 1 abnormal vertebrae development 0.211749302498922 0.593160349060888 1.13497393117831 0.28 21.1 21 1 impaired conditioned place preference behavior 0.211749302498922 0.593160349060888 1.13497393117831 0.28 21.1 21 1 abnormal inhibitory postsynaptic currents 0.0663844365735925 0.361337606076174 1.13258953216323 0.279411764705882 21.1 21 1 increased double-negative T cell number 0.081016784798369 0.412562569733648 1.12965789402993 0.278688524590164 21.1 21 1 abnormal epidermis stratum granulosum morphology 0.159248556416975 0.564147358908817 1.12596620156578 0.277777777777778 21.1 21 1 abnormal limb bone morphology 0.159248556416975 0.564147358908817 1.12596620156578 0.277777777777778 21.1 21 1 abnormal stomach glandular epithelium morphology 0.275667939182446 0.701507927075533 1.12596620156578 0.277777777777778 21.1 21 1 right pulmonary isomerism 0.275667939182446 0.701507927075533 1.12596620156578 0.277777777777778 21.1 21 1 abnormal radius morphology 0.275667939182446 0.701507927075533 1.12596620156578 0.277777777777778 21.1 21 1 abnormal mammary gland morphology 0.275667939182446 0.701507927075533 1.12596620156578 0.277777777777778 21.1 21 1 absent spleen 0.275667939182446 0.701507927075533 1.12596620156578 0.277777777777778 21.1 21 1 abnormal Peyer's patch follicle morphology 0.275667939182446 0.701507927075533 1.12596620156578 0.277777777777778 21.1 21 1 abnormal bile duct morphology 0.275667939182446 0.701507927075533 1.12596620156578 0.277777777777778 21.1 21 1 abnormal metacarpal bone morphology 0.275667939182446 0.701507927075533 1.12596620156578 0.277777777777778 21.1 21 1 increased susceptibility to autoimmune disorder 0.275667939182446 0.701507927075533 1.12596620156578 0.277777777777778 21.1 21 1 abnormal glycogen homeostasis 0.275667939182446 0.701507927075533 1.12596620156578 0.277777777777778 21.1 21 1 decreased pulmonary respiratory rate 0.275667939182446 0.701507927075533 1.12596620156578 0.277777777777778 21.1 21 1 decreased fluid intake 0.275667939182446 0.701507927075533 1.12596620156578 0.277777777777778 21.1 21 1 decreased litter size 0.000764033811629867 0.016038262501513 1.12516480213407 0.277580071174377 21.1 21 1 abnormal lung morphology 0.0226959847748303 0.192028102474117 1.12407382139509 0.277310924369748 21.1 21 1 abnormal pulmonary alveolus morphology 0.0338520503410088 0.244287918460407 1.12373656552308 0.277227722772277 21.1 21 1 decreased T cell proliferation 0.0124410257168931 0.122320361544552 1.12292304966966 0.277027027027027 21.1 21 1 spleen hypoplasia 0.0327522445361906 0.238568691899778 1.11953210898541 0.276190476190476 21.1 21 1 thrombocytosis 0.0955600874530523 0.441505332994711 1.11820091741705 0.275862068965517 21.1 21 1 abnormal middle ear morphology 0.201141871163317 0.56695796546034 1.11820091741705 0.275862068965517 21.1 21 1 focal hair loss 0.201141871163317 0.56695796546034 1.11820091741705 0.275862068965517 21.1 21 1 abnormal outer ear morphology 0.201141871163317 0.56695796546034 1.11820091741705 0.275862068965517 21.1 21 1 hyperkeratosis 0.0752583304071383 0.394947461788516 1.11617519111739 0.27536231884058 21.1 21 1 abnormal vertebrae morphology 0.0316754471961837 0.235413228674665 1.1156362364138 0.275229357798165 21.1 21 1 perinatal lethality 0.152233765590736 0.564147358908817 1.11470653955013 0.275 21.1 21 1 abnormal skin pigmentation 0.152233765590736 0.564147358908817 1.11470653955013 0.275 21.1 21 1 cochlear inner hair cell degeneration 0.117526697697123 0.490105046976685 1.11271954037089 0.274509803921569 21.1 21 1 decreased bone marrow cell number 0.0724846199657952 0.380793014075851 1.11054200702379 0.273972602739726 21.1 21 1 decreased circulating HDL cholesterol level 0.0238627863153623 0.199524978015004 1.10837297966632 0.2734375 21.1 21 1 hyperglycemia 0.0554833534470706 0.315385673484007 1.10549408881004 0.272727272727273 21.1 21 1 abnormal skeleton physiology 0.191148960648014 0.564147358908817 1.10549408881004 0.272727272727273 21.1 21 1 increased body size 0.258823502142685 0.664420496986512 1.10549408881004 0.272727272727273 21.1 21 1 abnormal oogenesis 0.258823502142685 0.664420496986512 1.10549408881004 0.272727272727273 21.1 21 1 decreased airway responsiveness 0.258823502142685 0.664420496986512 1.10549408881004 0.272727272727273 21.1 21 1 abnormal female reproductive system physiology 0.258823502142685 0.664420496986512 1.10549408881004 0.272727272727273 21.1 21 1 abnormal occipital bone morphology 0.258823502142685 0.664420496986512 1.10549408881004 0.272727272727273 21.1 21 1 abnormal bone mineralization 0.028597117948372 0.220917176697439 1.10549408881004 0.272727272727273 21.1 21 1 malocclusion 0.181755111458074 0.564147358908817 1.09553468260455 0.27027027027027 21.1 21 1 increased circulating phosphate level 0.181755111458074 0.564147358908817 1.09553468260455 0.27027027027027 21.1 21 1 abnormal pancreatic beta cell physiology 0.181755111458074 0.564147358908817 1.09553468260455 0.27027027027027 21.1 21 1 abnormal respiratory electron transport chain 0.181755111458074 0.564147358908817 1.09553468260455 0.27027027027027 21.1 21 1 enlarged liver 0.0496340116831936 0.30040049650108 1.09443914792194 0.27 21.1 21 1 abnormal brain wave pattern 0.132960368457993 0.535609581440093 1.09132108767145 0.269230769230769 21.1 21 1 increased percent body fat/body weight 0.132960368457993 0.535609581440093 1.09132108767145 0.269230769230769 21.1 21 1 abnormal stomach morphology 0.243640443582812 0.664420496986512 1.09132108767145 0.269230769230769 21.1 21 1 abnormal kidney cortex morphology 0.243640443582812 0.664420496986512 1.09132108767145 0.269230769230769 21.1 21 1 increased susceptibility to otitis media 0.243640443582812 0.664420496986512 1.09132108767145 0.269230769230769 21.1 21 1 increased leukemia incidence 0.243640443582812 0.664420496986512 1.09132108767145 0.269230769230769 21.1 21 1 increased blood urea nitrogen level 0.023171738917191 0.195720545183404 1.09024589448163 0.268965517241379 21.1 21 1 increased bone trabecula number 0.172927908408687 0.564147358908817 1.08751857517086 0.268292682926829 21.1 21 1 increased circulating creatinine level 0.0723329675936022 0.380398006108003 1.08406978476334 0.267441860465116 21.1 21 1 decreased B cell number 0.00969342999206003 0.103906060943932 1.08223935878653 0.266990291262136 21.1 21 1 altered response to myocardial infarction 0.164629578714241 0.564147358908817 1.08092755350315 0.266666666666667 21.1 21 1 abnormal heart tube morphology 0.22984391670139 0.635263047549674 1.08092755350315 0.266666666666667 21.1 21 1 arrested T cell differentiation 0.22984391670139 0.635263047549674 1.08092755350315 0.266666666666667 21.1 21 1 abnormal estrous cycle 0.22984391670139 0.635263047549674 1.08092755350315 0.266666666666667 21.1 21 1 abnormal spleen marginal zone morphology 0.22984391670139 0.635263047549674 1.08092755350315 0.266666666666667 21.1 21 1 organ of Corti degeneration 0.156821987075971 0.564147358908817 1.07541261700569 0.26530612244898 21.1 21 1 increased B cell number 0.0474218166923027 0.294969584317246 1.07399853072429 0.264957264957265 21.1 21 1 abnormal vision 0.217222908338456 0.60644442703918 1.07297955678622 0.264705882352941 21.1 21 1 abnormal brown adipose tissue morphology 0.217222908338456 0.60644442703918 1.07297955678622 0.264705882352941 21.1 21 1 abnormal bone remodeling 0.217222908338456 0.60644442703918 1.07297955678622 0.264705882352941 21.1 21 1 decreased pancreatic beta cell number 0.217222908338456 0.60644442703918 1.07297955678622 0.264705882352941 21.1 21 1 cochlear outer hair cell degeneration 0.106472336928998 0.455068622183648 1.0696678914875 0.263888888888889 21.1 21 1 increased sensitivity to xenobiotic induced morbidity/mortality 0.0568779413832196 0.318298940811606 1.06864428584971 0.263636363636364 21.1 21 1 abnormal frontal bone morphology 0.205613052253721 0.578904886792452 1.06670482253601 0.263157894736842 21.1 21 1 kyphoscoliosis 0.318050137811724 0.751441629177324 1.06670482253601 0.263157894736842 21.1 21 1 abnormal triglyceride level 0.318050137811724 0.751441629177324 1.06670482253601 0.263157894736842 21.1 21 1 decreased tumor incidence 0.318050137811724 0.751441629177324 1.06670482253601 0.263157894736842 21.1 21 1 abnormal neural crest cell migration 0.318050137811724 0.751441629177324 1.06670482253601 0.263157894736842 21.1 21 1 increased susceptibility to ischemic brain injury 0.318050137811724 0.751441629177324 1.06670482253601 0.263157894736842 21.1 21 1 abnormal photoreceptor inner segment morphology 0.318050137811724 0.751441629177324 1.06670482253601 0.263157894736842 21.1 21 1 increased left ventricle weight 0.318050137811724 0.751441629177324 1.06670482253601 0.263157894736842 21.1 21 1 abnormal cochlear inner hair cell morphology 0.318050137811724 0.751441629177324 1.06670482253601 0.263157894736842 21.1 21 1 increased circulating VLDL cholesterol level 0.318050137811724 0.751441629177324 1.06670482253601 0.263157894736842 21.1 21 1 eyelids fail to open 0.318050137811724 0.751441629177324 1.06670482253601 0.263157894736842 21.1 21 1 shortened RR interval 0.318050137811724 0.751441629177324 1.06670482253601 0.263157894736842 21.1 21 1 absent vitelline blood vessels 0.142536096172753 0.562962228636371 1.06670482253601 0.263157894736842 21.1 21 1 abnormal circulating amino acid level 0.142536096172753 0.562962228636371 1.06670482253601 0.263157894736842 21.1 21 1 abnormal male meiosis 0.135992999221162 0.547382824535016 1.06320742967523 0.262295081967213 21.1 21 1 hydronephrosis 0.0934441445544797 0.441505332994711 1.06162527576203 0.261904761904762 21.1 21 1 abnormal vibrissa morphology 0.194883906262138 0.564147358908817 1.06162527576203 0.261904761904762 21.1 21 1 abnormal postnatal growth 0.296072011791488 0.740924677395702 1.057429128427 0.260869565217391 21.1 21 1 abnormal cochlear ganglion morphology 0.296072011791488 0.740924677395702 1.057429128427 0.260869565217391 21.1 21 1 increased susceptibility to age related obesity 0.296072011791488 0.740924677395702 1.057429128427 0.260869565217391 21.1 21 1 decreased epididymis weight 0.296072011791488 0.740924677395702 1.057429128427 0.260869565217391 21.1 21 1 abnormal corneal stroma morphology 0.296072011791488 0.740924677395702 1.057429128427 0.260869565217391 21.1 21 1 abnormal lens development 0.296072011791488 0.740924677395702 1.057429128427 0.260869565217391 21.1 21 1 decreased percent body fat/body weight 0.118430978082718 0.493432420775653 1.0550149066726 0.26027397260274 21.1 21 1 abnormal interventricular septum morphology 0.175664888296925 0.564147358908817 1.05390436466557 0.26 21.1 21 1 abnormal cochlea morphology 0.167016215084549 0.564147358908817 1.05090178812807 0.259259259259259 21.1 21 1 abnormal mandible morphology 0.167016215084549 0.564147358908817 1.05090178812807 0.259259259259259 21.1 21 1 decreased tumor growth/size 0.167016215084549 0.564147358908817 1.05090178812807 0.259259259259259 21.1 21 1 abnormal long bone epiphyseal plate proliferative zone 0.167016215084549 0.564147358908817 1.05090178812807 0.259259259259259 21.1 21 1 cryptorchism 0.276897245779375 0.703556587207553 1.05090178812807 0.259259259259259 21.1 21 1 abnormal palate morphology 0.276897245779375 0.703556587207553 1.05090178812807 0.259259259259259 21.1 21 1 abnormal podocyte morphology 0.259875392689239 0.666776729566253 1.04605892274499 0.258064516129032 21.1 21 1 abnormal kidney morphology 0.0331559905288857 0.240804456760885 1.0423229980209 0.257142857142857 21.1 21 1 ovary cysts 0.244574720337707 0.664420496986512 1.0423229980209 0.257142857142857 21.1 21 1 increased circulating serum albumin level 0.244574720337707 0.664420496986512 1.0423229980209 0.257142857142857 21.1 21 1 increased red blood cell distribution width 0.244574720337707 0.664420496986512 1.0423229980209 0.257142857142857 21.1 21 1 acanthosis 0.230691210232326 0.636543966115264 1.03935341682995 0.256410256410256 21.1 21 1 increased autoantibody level 0.230691210232326 0.636543966115264 1.03935341682995 0.256410256410256 21.1 21 1 abnormal circulating hormone level 0.230691210232326 0.636543966115264 1.03935341682995 0.256410256410256 21.1 21 1 increased circulating insulin level 0.0425090723218126 0.273233378295888 1.03870382094444 0.25625 21.1 21 1 abnormal excitatory postsynaptic potential 0.119550527006478 0.496049934826712 1.03808591266309 0.25609756097561 21.1 21 1 abnormal organ of Corti morphology 0.218000982539352 0.607934354334795 1.03693631586058 0.255813953488372 21.1 21 1 decreased oxygen consumption 0.218000982539352 0.607934354334795 1.03693631586058 0.255813953488372 21.1 21 1 abnormal cardiovascular system physiology 0.0618970021221096 0.340638922076875 1.03622754189212 0.255639097744361 21.1 21 1 abnormal tibia morphology 0.206333304073667 0.579948128681636 1.03493063633281 0.25531914893617 21.1 21 1 increased respiratory quotient 0.206333304073667 0.579948128681636 1.03493063633281 0.25531914893617 21.1 21 1 improved glucose tolerance 0.0297515220928694 0.229478794437248 1.0340505932747 0.255102040816327 21.1 21 1 impaired hematopoiesis 0.195554269291595 0.564147358908817 1.03323957320154 0.254901960784314 21.1 21 1 increased kidney weight 0.195554269291595 0.564147358908817 1.03323957320154 0.254901960784314 21.1 21 1 abnormal platelet physiology 0.185556419168732 0.564147358908817 1.03179448288937 0.254545454545455 21.1 21 1 syndactyly 0.17625185641685 0.564147358908817 1.03054533702631 0.254237288135593 21.1 21 1 skin lesions 0.167567517930065 0.564147358908817 1.02945481286015 0.253968253968254 21.1 21 1 rib fusion 0.159441831460925 0.564147358908817 1.02849450053472 0.253731343283582 21.1 21 1 spleen hyperplasia 0.144663657207791 0.563587857955178 1.026881175828 0.253333333333333 21.1 21 1 decreased B cell proliferation 0.137926601931169 0.554268856710472 1.02619704446502 0.253164556962025 21.1 21 1 increased thermal nociceptive threshold 0.119919860313735 0.49716775421736 1.02450551087524 0.252747252747253 21.1 21 1 increased T cell proliferation 0.1001150908974 0.441505332994711 1.02284032516069 0.252336448598131 21.1 21 1 abnormal skeleton morphology 0.0916663376465327 0.441505332994711 1.02218149081276 0.252173913043478 21.1 21 1 increased body weight 0.0326641645328921 0.238568691899778 1.01336958140921 0.25 21.1 21 1 liver inflammation 0.0957092534216398 0.441505332994711 1.01336958140921 0.25 21.1 21 1 increased T cell number 0.137609123351761 0.553440087853687 1.01336958140921 0.25 21.1 21 1 increased food intake 0.14428749877035 0.562962228636371 1.01336958140921 0.25 21.1 21 1 abnormal osteoclast physiology 0.184660641729248 0.564147358908817 1.01336958140921 0.25 21.1 21 1 abnormal long bone epiphyseal plate morphology 0.19447813903817 0.564147358908817 1.01336958140921 0.25 21.1 21 1 increased erythrocyte cell number 0.19447813903817 0.564147358908817 1.01336958140921 0.25 21.1 21 1 decreased eosinophil cell number 0.184660641729248 0.564147358908817 1.01336958140921 0.25 21.1 21 1 abnormal eye physiology 0.19447813903817 0.564147358908817 1.01336958140921 0.25 21.1 21 1 abnormal incisor morphology 0.19447813903817 0.564147358908817 1.01336958140921 0.25 21.1 21 1 abnormal seminal vesicle morphology 0.205033110154026 0.57759893715531 1.01336958140921 0.25 21.1 21 1 abnormal hair growth 0.216418902902795 0.605559078707203 1.01336958140921 0.25 21.1 21 1 abnormal cardiovascular system morphology 0.228749178320085 0.633645413219611 1.01336958140921 0.25 21.1 21 1 small heart 0.228749178320085 0.633645413219611 1.01336958140921 0.25 21.1 21 1 abnormal osteoclast morphology 0.228749178320085 0.633645413219611 1.01336958140921 0.25 21.1 21 1 head bobbing 0.256843691779522 0.664420496986512 1.01336958140921 0.25 21.1 21 1 head tilt 0.273016774977951 0.69905221591112 1.01336958140921 0.25 21.1 21 1 abnormal retinal blood vessel morphology 0.273016774977951 0.69905221591112 1.01336958140921 0.25 21.1 21 1 abnormal lymphatic vessel morphology 0.290992153332891 0.736361120463444 1.01336958140921 0.25 21.1 21 1 abnormal long term potentiation 0.290992153332891 0.736361120463444 1.01336958140921 0.25 21.1 21 1 abnormal depression-related behavior 0.290992153332891 0.736361120463444 1.01336958140921 0.25 21.1 21 1 increased fatty acid level 0.290992153332891 0.736361120463444 1.01336958140921 0.25 21.1 21 1 abnormal serotonin level 0.290992153332891 0.736361120463444 1.01336958140921 0.25 21.1 21 1 abnormal foregut morphology 0.334251035258446 0.751441629177324 1.01336958140921 0.25 21.1 21 1 decreased metastatic potential 0.334251035258446 0.751441629177324 1.01336958140921 0.25 21.1 21 1 abnormal primitive streak formation 0.334251035258446 0.751441629177324 1.01336958140921 0.25 21.1 21 1 abnormal cardiac muscle contractility 0.334251035258446 0.751441629177324 1.01336958140921 0.25 21.1 21 1 straub tail 0.311196831401114 0.751441629177324 1.01336958140921 0.25 21.1 21 1 failure of blastocyst to hatch from the zona pellucida 0.311196831401114 0.751441629177324 1.01336958140921 0.25 21.1 21 1 hypoxia 0.311196831401114 0.751441629177324 1.01336958140921 0.25 21.1 21 1 decreased fatty acid level 0.334251035258446 0.751441629177324 1.01336958140921 0.25 21.1 21 1 increased triglyceride level 0.311196831401114 0.751441629177324 1.01336958140921 0.25 21.1 21 1 corneal vascularization 0.311196831401114 0.751441629177324 1.01336958140921 0.25 21.1 21 1 increased urine glucose level 0.361113018343188 0.758672832034359 1.01336958140921 0.25 21.1 21 1 decreased paired-pulse facilitation 0.361113018343188 0.758672832034359 1.01336958140921 0.25 21.1 21 1 abnormal heart right ventricle morphology 0.361113018343188 0.758672832034359 1.01336958140921 0.25 21.1 21 1 dilated vasculature 0.361113018343188 0.758672832034359 1.01336958140921 0.25 21.1 21 1 kidney atrophy 0.361113018343188 0.758672832034359 1.01336958140921 0.25 21.1 21 1 abnormal induced retinal neovascularization 0.361113018343188 0.758672832034359 1.01336958140921 0.25 21.1 21 1 thrombocytopenia 0.0802201049288877 0.412562569733648 1.00638082567535 0.248275862068966 21.1 21 1 abnormal humoral immune response 0.124674144123647 0.513009699988737 1.00371844253864 0.247619047619048 21.1 21 1 abnormal epidermal layer morphology 0.192351710771573 0.564147358908817 0.998683065736609 0.246376811594203 21.1 21 1 abnormal long bone morphology 0.213549380282846 0.597866160330422 0.996756965320531 0.245901639344262 21.1 21 1 abnormal long bone hypertrophic chondrocyte zone 0.252076916020878 0.664420496986512 0.992688569543712 0.244897959183673 21.1 21 1 abnormal rib morphology 0.107108854158874 0.457396179777166 0.99085025737789 0.244444444444444 21.1 21 1 abnormal ovarian follicle morphology 0.267249660390763 0.684990757570349 0.99085025737789 0.244444444444444 21.1 21 1 arrested B cell differentiation 0.283913299318501 0.720531572809468 0.988653250155323 0.24390243902439 21.1 21 1 increased circulating alanine transaminase level 0.189574388532891 0.564147358908817 0.987385745988457 0.243589743589744 21.1 21 1 abnormal branching of the mammary ductal tree 0.302350881109341 0.751441629177324 0.985981214344092 0.243243243243243 21.1 21 1 increased erythroid progenitor cell number 0.302350881109341 0.751441629177324 0.985981214344092 0.243243243243243 21.1 21 1 abnormal hair follicle development 0.302350881109341 0.751441629177324 0.985981214344092 0.243243243243243 21.1 21 1 abnormal action potential 0.209948596273367 0.589443716963882 0.984416164797514 0.242857142857143 21.1 21 1 abnormal tail morphology 0.221248521953912 0.616645040179671 0.982661412275594 0.242424242424242 21.1 21 1 abnormal aorta morphology 0.322941974992051 0.751441629177324 0.982661412275594 0.242424242424242 21.1 21 1 enlarged pericardium 0.322941974992051 0.751441629177324 0.982661412275594 0.242424242424242 21.1 21 1 abnormal QRS complex 0.322941974992051 0.751441629177324 0.982661412275594 0.242424242424242 21.1 21 1 increased osteoblast cell number 0.322941974992051 0.751441629177324 0.982661412275594 0.242424242424242 21.1 21 1 cardiovascular system phenotype 0.322941974992051 0.751441629177324 0.982661412275594 0.242424242424242 21.1 21 1 short limbs 0.186389429234202 0.564147358908817 0.978425802739923 0.241379310344828 21.1 21 1 cochlear ganglion degeneration 0.246526670375158 0.664420496986512 0.978425802739923 0.241379310344828 21.1 21 1 abnormal enzyme/coenzyme level 0.246526670375158 0.664420496986512 0.978425802739923 0.241379310344828 21.1 21 1 abnormal parietal bone morphology 0.346214318749504 0.751441629177324 0.978425802739923 0.241379310344828 21.1 21 1 short sternum 0.346214318749504 0.751441629177324 0.978425802739923 0.241379310344828 21.1 21 1 increased circulating glucose level 0.119241895251298 0.495182327942579 0.977434489869873 0.24113475177305 21.1 21 1 abnormal osteoblast physiology 0.260741097522051 0.668653072253713 0.975837374690346 0.240740740740741 21.1 21 1 abnormal hindlimb morphology 0.276207030038969 0.702520436832244 0.972834798152838 0.24 21.1 21 1 abnormal inner ear vestibule morphology 0.37293579297198 0.779168358157112 0.972834798152838 0.24 21.1 21 1 abnormal cochlear outer hair cell morphology 0.37293579297198 0.779168358157112 0.972834798152838 0.24 21.1 21 1 decreased placenta weight 0.37293579297198 0.779168358157112 0.972834798152838 0.24 21.1 21 1 corneal opacity 0.228247618409839 0.633645413219611 0.970551148391916 0.23943661971831 21.1 21 1 abnormal forelimb morphology 0.293121536822393 0.739293976037772 0.969310034391414 0.239130434782609 21.1 21 1 delayed wound healing 0.293121536822393 0.739293976037772 0.969310034391414 0.239130434782609 21.1 21 1 abnormal lymphocyte physiology 0.293121536822393 0.739293976037772 0.969310034391414 0.239130434782609 21.1 21 1 abnormal renal glomerulus morphology 0.171139329471889 0.564147358908817 0.966884738225297 0.238532110091743 21.1 21 1 abnormal spleen white pulp morphology 0.311734984648615 0.751441629177324 0.965113887056387 0.238095238095238 21.1 21 1 small ears 0.404291481759515 0.828739234344288 0.965113887056387 0.238095238095238 21.1 21 1 abnormal eye pigmentation 0.404291481759515 0.828739234344288 0.965113887056387 0.238095238095238 21.1 21 1 decreased cochlear outer hair cell number 0.404291481759515 0.828739234344288 0.965113887056387 0.238095238095238 21.1 21 1 increased bone ossification 0.404291481759515 0.828739234344288 0.965113887056387 0.238095238095238 21.1 21 1 abnormal T cell differentiation 0.188074570998731 0.564147358908817 0.963202770448354 0.237623762376238 21.1 21 1 abnormal axial skeleton morphology 0.234641972309084 0.644941332728007 0.960034340282406 0.236842105263158 21.1 21 1 decreased threshold for auditory brainstem response 0.332372965926602 0.751441629177324 0.960034340282406 0.236842105263158 21.1 21 1 abnormal T-helper 2 physiology 0.284012545583792 0.720531572809468 0.958094876968704 0.236363636363636 21.1 21 1 overexpanded pulmonary alveoli 0.355470918577773 0.751441629177324 0.953759606032194 0.235294117647059 21.1 21 1 abnormal spleen red pulp morphology 0.355470918577773 0.751441629177324 0.953759606032194 0.235294117647059 21.1 21 1 abnormal skin physiology 0.355470918577773 0.751441629177324 0.953759606032194 0.235294117647059 21.1 21 1 abnormal cervical vertebrae morphology 0.301023264115084 0.751441629177324 0.953759606032194 0.235294117647059 21.1 21 1 circling 0.228659779627522 0.633645413219611 0.953759606032194 0.235294117647059 21.1 21 1 abnormal T-helper 1 physiology 0.319640163495614 0.751441629177324 0.948686416638406 0.234042553191489 21.1 21 1 obese 0.253175906545026 0.664420496986512 0.94756636183718 0.233766233766234 21.1 21 1 abnormal dendritic cell physiology 0.206947697999477 0.581346582466063 0.947074375148791 0.233644859813084 21.1 21 1 abnormal hair cycle 0.381631397633712 0.790431391851673 0.945811609315259 0.233333333333333 21.1 21 1 increased metastatic potential 0.381631397633712 0.790431391851673 0.945811609315259 0.233333333333333 21.1 21 1 abnormal male reproductive system morphology 0.340139227712028 0.751441629177324 0.942669378055075 0.232558139534884 21.1 21 1 abnormal homeostasis 0.340139227712028 0.751441629177324 0.942669378055075 0.232558139534884 21.1 21 1 delayed endochondral bone ossification 0.340139227712028 0.751441629177324 0.942669378055075 0.232558139534884 21.1 21 1 abnormal eye electrophysiology 0.205876280988143 0.57931815492987 0.937994984444885 0.231404958677686 21.1 21 1 decreased IgA level 0.32640457247877 0.751441629177324 0.93541807514696 0.230769230769231 21.1 21 1 small seminal vesicle 0.41172439778873 0.833742034161209 0.93541807514696 0.230769230769231 21.1 21 1 pulmonary edema 0.41172439778873 0.833742034161209 0.93541807514696 0.230769230769231 21.1 21 1 decreased bone resorption 0.41172439778873 0.833742034161209 0.93541807514696 0.230769230769231 21.1 21 1 decreased Peyer's patch number 0.41172439778873 0.833742034161209 0.93541807514696 0.230769230769231 21.1 21 1 abnormal iris morphology 0.362877492634884 0.761736508801076 0.935418075146959 0.230769230769231 21.1 21 1 decreased B-1 B cell number 0.362877492634884 0.761736508801076 0.935418075146959 0.230769230769231 21.1 21 1 increased bone mineral density 0.225694457994614 0.626929049985038 0.932658729792544 0.230088495575221 21.1 21 1 oligodactyly 0.346661807736988 0.751441629177324 0.928922116291772 0.229166666666667 21.1 21 1 abnormal kidney physiology 0.346661807736988 0.751441629177324 0.928922116291772 0.229166666666667 21.1 21 1 abnormal phalanx morphology 0.346661807736988 0.751441629177324 0.928922116291772 0.229166666666667 21.1 21 1 increased circulating HDL cholesterol level 0.247827406343228 0.664420496986512 0.926509331574131 0.228571428571429 21.1 21 1 decreased bone mineralization 0.388329051389644 0.803968801774231 0.926509331574131 0.228571428571429 21.1 21 1 osteoporosis 0.368955250116595 0.773189709069106 0.921245074008369 0.227272727272727 21.1 21 1 decreased macrophage cell number 0.368955250116595 0.773189709069106 0.921245074008369 0.227272727272727 21.1 21 1 decreased blood urea nitrogen level 0.368955250116595 0.773189709069106 0.921245074008369 0.227272727272727 21.1 21 1 decreased sensitivity to induced morbidity/mortality 0.368955250116595 0.773189709069106 0.921245074008369 0.227272727272727 21.1 21 1 abnormal basisphenoid bone morphology 0.447076181646818 0.867263301583231 0.921245074008369 0.227272727272727 21.1 21 1 abnormal enterocyte morphology 0.447076181646818 0.867263301583231 0.921245074008369 0.227272727272727 21.1 21 1 increased activated T cell number 0.447076181646818 0.867263301583231 0.921245074008369 0.227272727272727 21.1 21 1 abnormal cochlear sensory epithelium morphology 0.447076181646818 0.867263301583231 0.921245074008369 0.227272727272727 21.1 21 1 prolonged PR interval 0.447076181646818 0.867263301583231 0.921245074008369 0.227272727272727 21.1 21 1 abnormal circulating lipid level 0.447076181646818 0.867263301583231 0.921245074008369 0.227272727272727 21.1 21 1 abnormal blood-brain barrier function 0.447076181646818 0.867263301583231 0.921245074008369 0.227272727272727 21.1 21 1 abnormal temporal bone morphology 0.447076181646818 0.867263301583231 0.921245074008369 0.227272727272727 21.1 21 1 increased bone volume 0.447076181646818 0.867263301583231 0.921245074008369 0.227272727272727 21.1 21 1 abnormal eyelid morphology 0.417143565742518 0.833742034161209 0.915301557401863 0.225806451612903 21.1 21 1 decreased circulating phosphate level 0.393661499334828 0.808949177691355 0.912032623268286 0.225 21.1 21 1 abnormal female reproductive system morphology 0.393661499334828 0.808949177691355 0.912032623268286 0.225 21.1 21 1 increased susceptibility to weight loss 0.393661499334828 0.808949177691355 0.912032623268286 0.225 21.1 21 1 abnormal skeleton development 0.332211535760389 0.751441629177324 0.900772961252628 0.222222222222222 21.1 21 1 decreased platelet aggregation 0.378365921555954 0.784321024892029 0.900772961252628 0.222222222222222 21.1 21 1 albuminuria 0.398013990038261 0.817555574087674 0.900772961252628 0.222222222222222 21.1 21 1 impaired wound healing 0.421275416078699 0.84102937198697 0.900772961252628 0.222222222222222 21.1 21 1 abnormal heart valve morphology 0.450246441219975 0.867263301583231 0.900772961252628 0.222222222222222 21.1 21 1 abnormal type II pneumocyte morphology 0.450246441219975 0.867263301583231 0.900772961252628 0.222222222222222 21.1 21 1 abnormal single cell response 0.450246441219975 0.867263301583231 0.900772961252628 0.222222222222222 21.1 21 1 increased inflammatory response 0.323026613169149 0.751441629177324 0.896032050930245 0.221052631578947 21.1 21 1 polyuria 0.349623961211544 0.751441629177324 0.894923786179558 0.220779220779221 21.1 21 1 kidney inflammation 0.401636023338629 0.824655062364704 0.891765231640101 0.22 21.1 21 1 abnormal response/metabolism to endogenous compounds 0.352900479603225 0.751441629177324 0.889787925139791 0.219512195121951 21.1 21 1 liver fibrosis 0.424528180589421 0.84718319231142 0.889787925139791 0.219512195121951 21.1 21 1 abnormal joint morphology 0.404697096245859 0.82922901722535 0.884395271048034 0.218181818181818 21.1 21 1 increased sensitivity to induced morbidity/mortality 0.279107382928255 0.708810224639137 0.881190940355831 0.217391304347826 21.1 21 1 abnormal sleep pattern 0.427150782598224 0.852075037460372 0.881190940355831 0.217391304347826 21.1 21 1 abnormal pulmonary artery morphology 0.489021784384409 0.867263301583231 0.881190940355831 0.217391304347826 21.1 21 1 abnormal carpal bone morphology 0.489021784384409 0.867263301583231 0.881190940355831 0.217391304347826 21.1 21 1 hypotension 0.489021784384409 0.867263301583231 0.881190940355831 0.217391304347826 21.1 21 1 abnormal cardiovascular development 0.489021784384409 0.867263301583231 0.881190940355831 0.217391304347826 21.1 21 1 abnormal sacral vertebrae morphology 0.489021784384409 0.867263301583231 0.881190940355831 0.217391304347826 21.1 21 1 abnormal B cell morphology 0.489021784384409 0.867263301583231 0.881190940355831 0.217391304347826 21.1 21 1 abnormal ulna morphology 0.489021784384409 0.867263301583231 0.881190940355831 0.217391304347826 21.1 21 1 abnormal chondrocyte physiology 0.489021784384409 0.867263301583231 0.881190940355831 0.217391304347826 21.1 21 1 abnormal kidney development 0.40731683399565 0.833742034161209 0.878253637221312 0.216666666666667 21.1 21 1 abnormal long bone metaphysis morphology 0.454082184346109 0.867263301583231 0.876427746083638 0.216216216216216 21.1 21 1 increased insulin secretion 0.454082184346109 0.867263301583231 0.876427746083638 0.216216216216216 21.1 21 1 abnormal calcium ion homeostasis 0.454082184346109 0.867263301583231 0.876427746083638 0.216216216216216 21.1 21 1 abnormal humerus morphology 0.454082184346109 0.867263301583231 0.876427746083638 0.216216216216216 21.1 21 1 increased trabecular bone volume 0.454082184346109 0.867263301583231 0.876427746083638 0.216216216216216 21.1 21 1 short femur 0.376235782922864 0.780230521067632 0.875182820307951 0.215909090909091 21.1 21 1 abnormal stria vascularis morphology 0.488169062079663 0.867263301583231 0.868602498350748 0.214285714285714 21.1 21 1 abnormal cartilage morphology 0.455289961300549 0.867263301583231 0.868602498350748 0.214285714285714 21.1 21 1 reddish skin 0.488169062079663 0.867263301583231 0.868602498350748 0.214285714285714 21.1 21 1 enhanced coordination 0.488169062079663 0.867263301583231 0.868602498350748 0.214285714285714 21.1 21 1 increased bone resorption 0.488169062079663 0.867263301583231 0.868602498350748 0.214285714285714 21.1 21 1 thick epidermis 0.411558694156028 0.833742034161209 0.868602498350748 0.214285714285714 21.1 21 1 lung inflammation 0.358947929920364 0.75603977618705 0.864344642966676 0.213235294117647 21.1 21 1 decreased bone trabecula number 0.456207706680011 0.867263301583231 0.862442196944005 0.212765957446809 21.1 21 1 decreased sensitivity to xenobiotic induced morbidity/mortality 0.487337803662449 0.867263301583231 0.859828735741145 0.212121212121212 21.1 21 1 abnormal leukocyte migration 0.456911838371681 0.867263301583231 0.857466568884713 0.211538461538462 21.1 21 1 increased susceptibility to injury 0.456911838371681 0.867263301583231 0.857466568884713 0.211538461538462 21.1 21 1 abnormal CD4-positive, alpha-beta T cell physiology 0.435001552207608 0.860148140792071 0.856368660345808 0.211267605633803 21.1 21 1 increased bone marrow cell number 0.486537975924644 0.867263301583231 0.853363858028805 0.210526315789474 21.1 21 1 abnormal compact bone morphology 0.486537975924644 0.867263301583231 0.853363858028805 0.210526315789474 21.1 21 1 impaired macrophage phagocytosis 0.485771037838687 0.867263301583231 0.848402440249568 0.209302325581395 21.1 21 1 abnormal blood circulation 0.485771037838687 0.867263301583231 0.848402440249568 0.209302325581395 21.1 21 1 abnormal femur morphology 0.458187633072986 0.867263301583231 0.84699547102859 0.208955223880597 21.1 21 1 abnormal hair shaft morphology 0.485035574822912 0.867263301583231 0.844474651174338 0.208333333333333 21.1 21 1 abnormal malleus morphology 0.529750928891242 0.932264192159154 0.844474651174338 0.208333333333333 21.1 21 1 abnormal body weight 0.529750928891242 0.932264192159154 0.844474651174338 0.208333333333333 21.1 21 1 small lymph nodes 0.529750928891242 0.932264192159154 0.844474651174338 0.208333333333333 21.1 21 1 hypopigmentation 0.529750928891242 0.932264192159154 0.844474651174338 0.208333333333333 21.1 21 1 decreased IgG level 0.439939576404311 0.867263301583231 0.839909923330153 0.207207207207207 21.1 21 1 aphagia 0.525200734252748 0.925566295751832 0.838650688062791 0.206896551724138 21.1 21 1 enlarged epididymis 0.525200734252748 0.925566295751832 0.838650688062791 0.206896551724138 21.1 21 1 increased double-positive T cell number 0.525200734252748 0.925566295751832 0.838650688062791 0.206896551724138 21.1 21 1 decreased regulatory T cell number 0.521525514610328 0.920067175598008 0.83453965527817 0.205882352941176 21.1 21 1 increased susceptibility to weight gain 0.521525514610328 0.920067175598008 0.83453965527817 0.205882352941176 21.1 21 1 increased liver weight 0.480016259744199 0.867263301583231 0.829120566607532 0.204545454545455 21.1 21 1 small kidney 0.480016259744199 0.867263301583231 0.829120566607532 0.204545454545455 21.1 21 1 abnormal gametogenesis 0.51580938325294 0.910628701803895 0.829120566607532 0.204545454545455 21.1 21 1 cochlear hair cell degeneration 0.51580938325294 0.910628701803895 0.829120566607532 0.204545454545455 21.1 21 1 polyphagia 0.511436182186677 0.903549363060624 0.825708547814909 0.203703703703704 21.1 21 1 increased lymphocyte cell number 0.506335170224478 0.894855229792816 0.822444877665442 0.202898550724638 21.1 21 1 abnormal pancreatic beta cell morphology 0.549647573552665 0.958127778004383 0.810695665127365 0.2 21.1 21 1 increased circulating calcium level 0.538120953671881 0.943655884567363 0.810695665127365 0.2 21.1 21 1 abnormal digestive system physiology 0.541460440261358 0.948843145579519 0.810695665127365 0.2 21.1 21 1 decreased osteoclast cell number 0.545258231556609 0.950809569573828 0.810695665127365 0.2 21.1 21 1 ruffled hair 0.568954712871058 0.958474550856908 0.810695665127365 0.2 21.1 21 1 abnormal pain threshold 0.561093068407507 0.958474550856908 0.810695665127365 0.2 21.1 21 1 abnormal artery morphology 0.5548246304155 0.958474550856908 0.810695665127365 0.2 21.1 21 1 increased pre-B cell number 0.568954712871058 0.958474550856908 0.810695665127365 0.2 21.1 21 1 abnormal keratinocyte physiology 0.568954712871058 0.958474550856908 0.810695665127365 0.2 21.1 21 1 abnormal feces composition 0.568954712871058 0.958474550856908 0.810695665127365 0.2 21.1 21 1 impaired behavioral response to xenobiotic 0.5548246304155 0.958474550856908 0.810695665127365 0.2 21.1 21 1 decreased bone volume 0.5548246304155 0.958474550856908 0.810695665127365 0.2 21.1 21 1 impaired adaptive thermogenesis 0.5548246304155 0.958474550856908 0.810695665127365 0.2 21.1 21 1 abnormal urine homeostasis 0.540538795792018 0.947561842517719 0.802250918615621 0.197916666666667 21.1 21 1 short humerus 0.579979547604361 0.958474550856908 0.790922600124258 0.195121951219512 21.1 21 1 abnormal cytokine secretion 0.570538957916993 0.958474550856908 0.789638634864316 0.194805194805195 21.1 21 1 abnormal reflex 0.58706064766921 0.959154916963652 0.788176341096049 0.194444444444444 21.1 21 1 short radius 0.58706064766921 0.959154916963652 0.788176341096049 0.194444444444444 21.1 21 1 increased eosinophil cell number 0.584828457021467 0.958474550856908 0.78454419205874 0.193548387096774 21.1 21 1 osteopetrosis 0.595640949047104 0.967138943051351 0.78454419205874 0.193548387096774 21.1 21 1 absent mature ovarian follicles 0.595640949047104 0.967138943051351 0.78454419205874 0.193548387096774 21.1 21 1 decreased double-negative T cell number 0.595640949047104 0.967138943051351 0.78454419205874 0.193548387096774 21.1 21 1 small cranium 0.595640949047104 0.967138943051351 0.78454419205874 0.193548387096774 21.1 21 1 abnormal trabecular bone morphology 0.586856633052616 0.959154916963652 0.783445390669302 0.19327731092437 21.1 21 1 abnormal erythrocyte osmotic lysis 0.606390502176374 0.983950668078102 0.779515062622466 0.192307692307692 21.1 21 1 increased systemic arterial blood pressure 0.601882182974321 0.976953951157341 0.776197977249605 0.191489361702128 21.1 21 1 increased circulating aspartate transaminase level 0.608789404843709 0.987521124583454 0.772091109645109 0.19047619047619 21.1 21 1 glomerulosclerosis 0.614677825696676 0.991149842037808 0.768763130724225 0.189655172413793 21.1 21 1 skin inflammation 0.618088955777934 0.991293538038433 0.766874277823183 0.189189189189189 21.1 21 1 abnormal diaphragm morphology 0.628681330854001 1 0.760027186056905 0.1875 21.1 21 1 abnormal lymph node morphology 0.628846784855416 1 0.760027186056905 0.1875 21.1 21 1 abnormal lumbar vertebrae morphology 0.628681330854001 1 0.760027186056905 0.1875 21.1 21 1 abnormal colon morphology 0.638762782201777 1 0.755733247152628 0.186440677966102 21.1 21 1 abnormal thoracic vertebrae morphology 0.638762782201777 1 0.755733247152628 0.186440677966102 21.1 21 1 kidney failure 0.637557642011734 1 0.75413550244406 0.186046511627907 21.1 21 1 decreased IgM level 0.659486981074206 1 0.752191854241885 0.185567010309278 21.1 21 1 abnormal bone trabecula morphology 0.641877788757373 1 0.75064413437719 0.185185185185185 21.1 21 1 abnormal epidermis stratum corneum morphology 0.654800811150601 1 0.744516427157784 0.183673469387755 21.1 21 1 abnormal myelopoiesis 0.664612810624799 1 0.736996059206695 0.181818181818182 21.1 21 1 diarrhea 0.660091003563235 1 0.736996059206695 0.181818181818182 21.1 21 1 abnormal middle ear ossicle morphology 0.660091003563235 1 0.736996059206695 0.181818181818182 21.1 21 1 increased urine protein level 0.701879887782882 1 0.727547391780968 0.179487179487179 21.1 21 1 increased vascular permeability 0.676087940721367 1 0.727547391780968 0.179487179487179 21.1 21 1 decreased inflammatory response 0.713284164331901 1 0.72383541529229 0.178571428571429 21.1 21 1 abnormal spleen germinal center morphology 0.675292729339484 1 0.72383541529229 0.178571428571429 21.1 21 1 increased circulating corticosterone level 0.690419206099003 1 0.720618369002102 0.177777777777778 21.1 21 1 abnormal immune system physiology 0.749732740982751 1 0.719165509387178 0.17741935483871 21.1 21 1 abnormal response to infection 0.720454814221334 1 0.718337931125513 0.177215189873418 21.1 21 1 short maxilla 0.689783608338858 1 0.715319704524146 0.176470588235294 21.1 21 1 decreased osteoblast cell number 0.689783608338858 1 0.715319704524146 0.176470588235294 21.1 21 1 decreased susceptibility to injury 0.717471057452196 1 0.715319704524146 0.176470588235294 21.1 21 1 abnormal T cell activation 0.728233605136288 1 0.712097543692956 0.175675675675676 21.1 21 1 abnormal blood homeostasis 0.76072250388734 1 0.711136548357338 0.175438596491228 21.1 21 1 abnormal inner ear morphology 0.714931234647755 1 0.704952752284665 0.173913043478261 21.1 21 1 decreased body temperature 0.726037183620695 1 0.70156355636022 0.173076923076923 21.1 21 1 increased neutrophil cell number 0.808177625045656 1 0.698875573385659 0.172413793103448 21.1 21 1 abnormal circulating glucose level 0.706561894982555 1 0.698875573385659 0.172413793103448 21.1 21 1 decreased granulocyte number 0.706561894982555 1 0.698875573385659 0.172413793103448 21.1 21 1 decreased bone strength 0.706561894982555 1 0.698875573385659 0.172413793103448 21.1 21 1 dehydration 0.755077725547139 1 0.694881998680598 0.171428571428571 21.1 21 1 abnormal systemic arterial blood pressure 0.743835257060656 1 0.675579720939471 0.166666666666667 21.1 21 1 abnormal fat pad morphology 0.735655660297564 1 0.675579720939471 0.166666666666667 21.1 21 1 abnormal NK cell physiology 0.792922612897838 1 0.66450464354702 0.163934426229508 21.1 21 1 increased fluid intake 0.780497490275601 1 0.661792379695808 0.163265306122449 21.1 21 1 abnormal intestinal mucosa morphology 0.774249584716666 1 0.659868564638553 0.162790697674419 21.1 21 1 increased brown adipose tissue amount 0.768173250857312 1 0.657320809562728 0.162162162162162 21.1 21 1 abnormal body temperature homeostasis 0.762581566307268 1 0.653786826715617 0.161290322580645 21.1 21 1 autoimmune response 0.762581566307268 1 0.653786826715617 0.161290322580645 21.1 21 1 short mandible 0.804636227250408 1 0.651451873763061 0.160714285714286 21.1 21 1 abnormal food intake 0.829472924753006 1 0.646206689594276 0.159420289855072 21.1 21 1 kidney cortex cysts 0.787377906206022 1 0.633355988380754 0.15625 21.1 21 1 abnormal leukocyte adhesion 0.811590978662641 1 0.623612050097973 0.153846153846154 21.1 21 1 abnormal immune system morphology 0.832082374387676 1 0.616833658249082 0.152173913043478 21.1 21 1 absent vibrissae 0.810107710249376 1 0.614163382672246 0.151515151515152 21.1 21 1 abnormal T cell subpopulation ratio 0.810107710249376 1 0.614163382672246 0.151515151515152 21.1 21 1 impaired ovarian folliculogenesis 0.830770217603182 1 0.608021748845524 0.15 21.1 21 1 increased susceptibility to viral infection induced morbidity/mortality 0.830853245061534 1 0.596099753770121 0.147058823529412 21.1 21 1 decreased urine osmolality 0.877501701765703 1 0.579068332233832 0.142857142857143 21.1 21 1 increased body length 0.890166973852769 1 0.567486965589155 0.14 21.1 21 1 abnormal circulating protein level 0.890166973852769 1 0.567486965589155 0.14 21.1 21 1 abnormal inflammatory response 0.925425129697287 1 0.562983100782892 0.138888888888889 21.1 21 1 increased susceptibility to bacterial infection induced morbidity/mortality 0.925425129697287 1 0.562983100782892 0.138888888888889 21.1 21 1 abnormal cartilage development 0.904306123044472 1 0.540463776751577 0.133333333333333 21.1 21 1 abnormal intestinal epithelium morphology 0.933637240796876 1 0.506684790704603 0.125 21.1 21 1 decreased susceptibility to induced arthritis 0.951344628948961 1 0.497795583850136 0.12280701754386 21.1 21 1 increased susceptibility to parasitic infection 0.978858569586913 1 0.495425128688945 0.122222222222222 21.1 21 1 abnormal cytotoxic T cell physiology 0.938257640562365 1 0.482556943528193 0.119047619047619 21.1 21 1 hypertension 0.952941948541264 1 0.460622537004185 0.113636363636364 21.1 21 1 impaired natural killer cell mediated cytotoxicity 0.979752857413665 1 0.426681929014402 0.105263157894737 21.1 21 1 abnormal thrombosis 0.982691219404897 1 0.397399835846747 0.0980392156862745 21.1 21 1 heart hemorrhage 0.000177709364078593 0.00348072474917717 2.43290831815422 1 21.2 21 2 small hair follicles 0.0020959332795073 0.0255570295724236 2.43290831815422 1 21.2 21 2 abnormal pineal gland morphology 0.0020959332795073 0.0255570295724236 2.43290831815422 1 21.2 21 2 sinus inflammation 0.0020959332795073 0.0255570295724236 2.43290831815422 1 21.2 21 2 absent frontal bone 0.0020959332795073 0.0255570295724236 2.43290831815422 1 21.2 21 2 abnormal inner cell mass proliferation 0.0020959332795073 0.0255570295724236 2.43290831815422 1 21.2 21 2 corneal deposits 0.0020959332795073 0.0255570295724236 2.43290831815422 1 21.2 21 2 abnormal paranode morphology 0.0020959332795073 0.0255570295724236 2.43290831815422 1 21.2 21 2 decreased pre-pro B cell number 0.0020959332795073 0.0255570295724236 2.43290831815422 1 21.2 21 2 absent ectoplacental cone 0.000610322621589483 0.00942967404474433 2.43290831815422 1 21.2 21 2 abnormal extraembryonic tissue physiology 0.00105949194267466 0.0147651622614863 2.12879477838494 0.875 21.2 21 2 abnormal cerebellum deep nucleus morphology 0.00105949194267466 0.0147651622614863 2.12879477838494 0.875 21.2 21 2 abnormal visual evoked potential 0.00105949194267466 0.0147651622614863 2.12879477838494 0.875 21.2 21 2 broad head 0.00320600216665481 0.0354411132973046 2.08534998698933 0.857142857142857 21.2 21 2 polyphalangy 0.00320600216665481 0.0354411132973046 2.08534998698933 0.857142857142857 21.2 21 2 abnormal lacrimal gland morphology 0.00320600216665481 0.0354411132973046 2.08534998698933 0.857142857142857 21.2 21 2 abnormal central pattern generator function 0.00320600216665481 0.0354411132973046 2.08534998698933 0.857142857142857 21.2 21 2 dysmyelination 0.00320600216665481 0.0354411132973046 2.08534998698933 0.857142857142857 21.2 21 2 abnormal hypoglossal nerve topology 2.87848629388307e-06 0.000111878666500533 2.02742359846185 0.833333333333333 21.2 21 2 increased osteosarcoma incidence 0.000156675084716844 0.00322090308457148 2.02742359846185 0.833333333333333 21.2 21 2 decreased red blood cell distribution width 0.000156675084716844 0.00322090308457148 2.02742359846185 0.833333333333333 21.2 21 2 thin tail 0.00952398656909641 0.0771487554212405 2.02742359846185 0.833333333333333 21.2 21 2 delayed brain development 0.00952398656909641 0.0771487554212405 2.02742359846185 0.833333333333333 21.2 21 2 reduced NMDA-mediated synaptic currents 0.00952398656909641 0.0771487554212405 2.02742359846185 0.833333333333333 21.2 21 2 chromatolysis 0.00952398656909641 0.0771487554212405 2.02742359846185 0.833333333333333 21.2 21 2 decreased liver function 0.00952398656909641 0.0771487554212405 2.02742359846185 0.833333333333333 21.2 21 2 absent parietal bone 0.00952398656909641 0.0771487554212405 2.02742359846185 0.833333333333333 21.2 21 2 delayed chorioallantoic fusion 0.00952398656909641 0.0771487554212405 2.02742359846185 0.833333333333333 21.2 21 2 myocardium hypoplasia 0.00952398656909641 0.0771487554212405 2.02742359846185 0.833333333333333 21.2 21 2 abnormal intestinal enteroendocrine cell morphology 0.00952398656909641 0.0771487554212405 2.02742359846185 0.833333333333333 21.2 21 2 abnormal vertebral artery origin 0.00952398656909641 0.0771487554212405 2.02742359846185 0.833333333333333 21.2 21 2 abnormal sphenoid bone morphology 0.000451797168679306 0.00744268514628989 1.99056135121709 0.818181818181818 21.2 21 2 abnormal hippocampus neuron morphology 0.00128112190674964 0.0174558977651648 1.94632665452338 0.8 21.2 21 2 lethality during fetal growth through weaning, complete penetrance 0.00128112190674964 0.0174558977651648 1.94632665452338 0.8 21.2 21 2 increased brain weight 2.34631287683621e-07 1.28273698486375e-05 1.89226202523106 0.777777777777778 21.2 21 2 heart hyperplasia 0.00355966118103155 0.0377597321442046 1.89226202523106 0.777777777777778 21.2 21 2 abnormal head movements 0.00355966118103155 0.0377597321442046 1.89226202523106 0.777777777777778 21.2 21 2 abnormal NMDA-mediated synaptic currents 0.00355966118103155 0.0377597321442046 1.89226202523106 0.777777777777778 21.2 21 2 abnormal thymus physiology 0.00355966118103155 0.0377597321442046 1.89226202523106 0.777777777777778 21.2 21 2 increased neuronal precursor cell number 0.00355966118103155 0.0377597321442046 1.89226202523106 0.777777777777778 21.2 21 2 abnormal ductus venosus valve topology 0.00355966118103155 0.0377597321442046 1.89226202523106 0.777777777777778 21.2 21 2 abnormal infrahyoid muscle connection 0.00355966118103155 0.0377597321442046 1.89226202523106 0.777777777777778 21.2 21 2 symmetric azygos veins 0.00355966118103155 0.0377597321442046 1.89226202523106 0.777777777777778 21.2 21 2 cerebellum atrophy 0.00355966118103155 0.0377597321442046 1.89226202523106 0.777777777777778 21.2 21 2 abnormal lysosome physiology 4.11456650573596e-06 0.000150514473279679 1.87997460948281 0.772727272727273 21.2 21 2 increased thymocyte apoptosis 6.30838380520456e-07 2.96077447461252e-05 1.87146793704171 0.769230769230769 21.2 21 2 absent hypoglossal nerve 0.000500357596507525 0.00802993239556431 1.87146793704171 0.769230769230769 21.2 21 2 increased brain size 7.33021679043506e-05 0.00172833310580163 1.86045930211793 0.764705882352941 21.2 21 2 scoliosis 1.05461149296886e-07 6.17257903237657e-06 1.82468123861567 0.75 21.2 21 2 failure of vascular branching 0.0096455328385953 0.0771487554212405 1.82468123861567 0.75 21.2 21 2 liver cysts 0.0096455328385953 0.0771487554212405 1.82468123861567 0.75 21.2 21 2 binucleate 0.0096455328385953 0.0771487554212405 1.82468123861567 0.75 21.2 21 2 tau protein deposits 0.0096455328385953 0.0771487554212405 1.82468123861567 0.75 21.2 21 2 abnormal somite size 0.0096455328385953 0.0771487554212405 1.82468123861567 0.75 21.2 21 2 abnormal meiotic spindle morphology 0.0096455328385953 0.0771487554212405 1.82468123861567 0.75 21.2 21 2 decreased hippocampus pyramidal cell number 0.0096455328385953 0.0771487554212405 1.82468123861567 0.75 21.2 21 2 abnormal hepatic vein morphology 0.0096455328385953 0.0771487554212405 1.82468123861567 0.75 21.2 21 2 increased heart right ventricle size 0.0096455328385953 0.0771487554212405 1.82468123861567 0.75 21.2 21 2 increased cardiac stroke volume 0.0096455328385953 0.0771487554212405 1.82468123861567 0.75 21.2 21 2 loss of dopaminergic neurons 0.0013371634205667 0.0177397013795182 1.82468123861566 0.75 21.2 21 2 abnormal pulmonary valve cusp morphology 0.0013371634205667 0.0177397013795182 1.82468123861566 0.75 21.2 21 2 unresponsive to tactile stimuli 7.5507715121661e-05 0.00174721340804774 1.792669287061 0.736842105263158 21.2 21 2 abnormal trophectoderm morphology 0.000506353903025495 0.00804827689313686 1.78413276664643 0.733333333333333 21.2 21 2 abnormal cerebral aqueduct morphology 0.000506353903025495 0.00804827689313686 1.78413276664643 0.733333333333333 21.2 21 2 heterochrony 0.000506353903025495 0.00804827689313686 1.78413276664643 0.733333333333333 21.2 21 2 decreased embryonic cilium length 0.00349265454160386 0.0377597321442046 1.76938786774852 0.727272727272727 21.2 21 2 abnormal glycogen homeostasis 0.000193143969106488 0.00368157565634015 1.75710045200027 0.722222222222222 21.2 21 2 abnormal aerobic respiration 0.000193143969106488 0.00368157565634015 1.75710045200027 0.722222222222222 21.2 21 2 increased adipocyte glucose uptake 0.000193143969106488 0.00368157565634015 1.75710045200027 0.722222222222222 21.2 21 2 subcutaneous edema 4.47187010338808e-06 0.000158911098316826 1.73779165582444 0.714285714285714 21.2 21 2 absent segment of posterior cerebral artery 7.41224491862555e-05 0.00173126377794188 1.73779165582444 0.714285714285714 21.2 21 2 increased muscle cell glucose uptake 7.41224491862555e-05 0.00173126377794188 1.73779165582444 0.714285714285714 21.2 21 2 absent olfactory bulb 0.00129215959816016 0.0174558977651648 1.73779165582444 0.714285714285714 21.2 21 2 split sternum 0.00129215959816016 0.0174558977651648 1.73779165582444 0.714285714285714 21.2 21 2 cochlear degeneration 0.0253189475752004 0.153799467871333 1.73779165582444 0.714285714285714 21.2 21 2 decreased Schwann cell number 0.0253189475752004 0.153799467871333 1.73779165582444 0.714285714285714 21.2 21 2 retina hyperplasia 0.0253189475752004 0.153799467871333 1.73779165582444 0.714285714285714 21.2 21 2 excessive tearing 0.0253189475752004 0.153799467871333 1.73779165582444 0.714285714285714 21.2 21 2 abnormal sinus venosus morphology 0.0253189475752004 0.153799467871333 1.73779165582444 0.714285714285714 21.2 21 2 aorta coarctation 0.0253189475752004 0.153799467871333 1.73779165582444 0.714285714285714 21.2 21 2 abnormal cerebellum white matter morphology 0.0253189475752004 0.153799467871333 1.73779165582444 0.714285714285714 21.2 21 2 decreased DN2 thymocyte number 0.0253189475752004 0.153799467871333 1.73779165582444 0.714285714285714 21.2 21 2 arteritis 0.0253189475752004 0.153799467871333 1.73779165582444 0.714285714285714 21.2 21 2 increased oligodendrocyte number 0.0253189475752004 0.153799467871333 1.73779165582444 0.714285714285714 21.2 21 2 focal dorsal hair loss 0.0253189475752004 0.153799467871333 1.73779165582444 0.714285714285714 21.2 21 2 abnormal aortic valve cusp morphology 0.0253189475752004 0.153799467871333 1.73779165582444 0.714285714285714 21.2 21 2 increased compact bone volume 0.0253189475752004 0.153799467871333 1.73779165582444 0.714285714285714 21.2 21 2 abnormal outer hair cell kinocilium morphology 0.0253189475752004 0.153799467871333 1.73779165582444 0.714285714285714 21.2 21 2 small tail bud 0.0253189475752004 0.153799467871333 1.73779165582444 0.714285714285714 21.2 21 2 ductus venosus stenosis 0.0253189475752004 0.153799467871333 1.73779165582444 0.714285714285714 21.2 21 2 absent connection between subcutaneous lymph vessels and lymph sac 0.0253189475752004 0.153799467871333 1.73779165582444 0.714285714285714 21.2 21 2 embryo tumor 0.0253189475752004 0.153799467871333 1.73779165582444 0.714285714285714 21.2 21 2 abnormal cell differentiation 4.32892909927407e-08 2.79693795699851e-06 1.72083759088957 0.707317073170732 21.2 21 2 abnormal bone marrow cavity morphology 0.000485001859227641 0.00785955781647399 1.71734704810886 0.705882352941177 21.2 21 2 abnormal atrioventricular cushion morphology 1.10731457165309e-05 0.000355412257675751 1.71204659425667 0.703703703703704 21.2 21 2 absent ductus venosus valve 0.000183938583828091 0.00358860570409707 1.70303582270795 0.7 21.2 21 2 increased cranium width 0.00887625282102266 0.0742174080413239 1.70303582270795 0.7 21.2 21 2 peritoneal inflammation 0.00887625282102266 0.0742174080413239 1.70303582270795 0.7 21.2 21 2 abnormal plasma membrane morphology 0.00887625282102266 0.0742174080413239 1.70303582270795 0.7 21.2 21 2 decreased transitional stage T2 B cell number 0.00887625282102266 0.0742174080413239 1.70303582270795 0.7 21.2 21 2 increased circulating fructosamine level 0.00887625282102266 0.0742174080413239 1.70303582270795 0.7 21.2 21 2 abnormal inferior vena cava valve morphology 0.00887625282102266 0.0742174080413239 1.70303582270795 0.7 21.2 21 2 thin ventricle myocardium compact layer 0.00887625282102266 0.0742174080413239 1.70303582270795 0.7 21.2 21 2 embryonic lethality between implantation and placentation, complete penetrance 1.64534041609233e-08 1.13688452361935e-06 1.69245796045511 0.695652173913043 21.2 21 2 ventricular hypoplasia 2.70365643195894e-05 0.000747260597166428 1.68432114333754 0.692307692307692 21.2 21 2 abnormal pulmonary alveolus epithelial cell morphology 0.00321997652469983 0.0354411132973046 1.68432114333754 0.692307692307692 21.2 21 2 abnormal coping response 0.00321997652469983 0.0354411132973046 1.68432114333754 0.692307692307692 21.2 21 2 abnormal retinal inner plexiform layer morphology 0.00321997652469983 0.0354411132973046 1.68432114333754 0.692307692307692 21.2 21 2 increased circulating thyroxine level 0.00321997652469983 0.0354411132973046 1.68432114333754 0.692307692307692 21.2 21 2 empty decidua capsularis 0.00321997652469983 0.0354411132973046 1.68432114333754 0.692307692307692 21.2 21 2 increased mortality induced by gamma-irradiation 1.04477790222641e-05 0.000339723533567083 1.6778678056236 0.689655172413793 21.2 21 2 dystonia 0.00119267380237694 0.0164364325950839 1.67262446873103 0.6875 21.2 21 2 abnormal nasal septum morphology 0.000448022519406946 0.00740502336893541 1.66462148084236 0.684210526315789 21.2 21 2 abnormal blastocyst morphology 0.000448022519406946 0.00740502336893541 1.66462148084236 0.684210526315789 21.2 21 2 abnormal germ layer development 0.000170013575338422 0.0033536086257714 1.65880112601424 0.681818181818182 21.2 21 2 abnormal vascular branching morphogenesis 0.000170013575338422 0.0033536086257714 1.65880112601424 0.681818181818182 21.2 21 2 increased adenoma incidence 0.000170013575338422 0.0033536086257714 1.65880112601424 0.681818181818182 21.2 21 2 embryonic lethality before implantation, incomplete penetrance 0.000170013575338422 0.0033536086257714 1.65880112601424 0.681818181818182 21.2 21 2 increased cellular sensitivity to ionizing radiation 6.50119370378884e-05 0.00156248496021012 1.65437765634487 0.68 21.2 21 2 abnormal object recognition memory 9.66687584551768e-06 0.00031893232027676 1.64809918326576 0.67741935483871 21.2 21 2 inner cell mass degeneration 9.66687584551768e-06 0.00031893232027676 1.64809918326576 0.67741935483871 21.2 21 2 abnormal cell cycle 4.95522355980317e-17 1.36956873389004e-14 1.62899078693804 0.669565217391304 21.2 21 2 enhanced paired-pulse facilitation 2.27355841627656e-05 0.000639036899490164 1.62193887876948 0.666666666666667 21.2 21 2 abnormal synaptic transmission 2.27355841627656e-05 0.000639036899490164 1.62193887876948 0.666666666666667 21.2 21 2 abnormal embryonic/fetal subventricular zone morphology 0.000403570853111758 0.00687590751448972 1.62193887876948 0.666666666666667 21.2 21 2 absent inner cell mass 0.00106871763946995 0.0148515928948687 1.62193887876948 0.666666666666667 21.2 21 2 delayed intramembranous bone ossification 0.0028637709884295 0.0330562892515934 1.62193887876948 0.666666666666667 21.2 21 2 abnormal cholinergic neuron morphology 0.0218172761537228 0.145888372130068 1.62193887876948 0.666666666666667 21.2 21 2 abnormal vomeronasal organ morphology 0.0218172761537228 0.145888372130068 1.62193887876948 0.666666666666667 21.2 21 2 pancreas cysts 0.0218172761537228 0.145888372130068 1.62193887876948 0.666666666666667 21.2 21 2 decreased fear-related response 0.0218172761537228 0.145888372130068 1.62193887876948 0.666666666666667 21.2 21 2 decreased cellular sensitivity to ionizing radiation 0.0218172761537228 0.145888372130068 1.62193887876948 0.666666666666667 21.2 21 2 abnormal proprioceptive neuron morphology 0.0218172761537228 0.145888372130068 1.62193887876948 0.666666666666667 21.2 21 2 liver hyperplasia 0.0218172761537228 0.145888372130068 1.62193887876948 0.666666666666667 21.2 21 2 decreased transitional stage T1 B cell number 0.0218172761537228 0.145888372130068 1.62193887876948 0.666666666666667 21.2 21 2 retropulsion 0.0218172761537228 0.145888372130068 1.62193887876948 0.666666666666667 21.2 21 2 abnormal ventricle myocardium morphology 0.0218172761537228 0.145888372130068 1.62193887876948 0.666666666666667 21.2 21 2 iris coloboma 0.0218172761537228 0.145888372130068 1.62193887876948 0.666666666666667 21.2 21 2 interstitial pneumonia 0.00780363678367817 0.068110689471577 1.62193887876948 0.666666666666667 21.2 21 2 abnormal embryonic growth/weight/body size 0.00780363678367817 0.068110689471577 1.62193887876948 0.666666666666667 21.2 21 2 abnormal corticospinal tract morphology 0.00780363678367817 0.068110689471577 1.62193887876948 0.666666666666667 21.2 21 2 abnormal vascular endothelial cell development 0.00780363678367817 0.068110689471577 1.62193887876948 0.666666666666667 21.2 21 2 prenatal growth retardation 0.00780363678367817 0.068110689471577 1.62193887876948 0.666666666666667 21.2 21 2 abnormal spongiotrophoblast layer morphology 2.0383466946833e-05 0.000579472846059967 1.59659608378871 0.65625 21.2 21 2 abnormal Schwann cell morphology 0.000136743196616898 0.0028583924502902 1.59074774648545 0.653846153846154 21.2 21 2 abnormal nerve conduction 0.000136743196616898 0.0028583924502902 1.59074774648545 0.653846153846154 21.2 21 2 failure to gastrulate 4.23049239726282e-07 2.08383165112698e-05 1.58667933792667 0.652173913043478 21.2 21 2 abnormal circulating enzyme level 0.000938464114053393 0.0135329245432337 1.58139040680024 0.65 21.2 21 2 increased mammary adenocarcinoma incidence 0.000938464114053393 0.0135329245432337 1.58139040680024 0.65 21.2 21 2 decreased myocardial infarction size 0.000938464114053393 0.0135329245432337 1.58139040680024 0.65 21.2 21 2 increased skin tumor incidence 0.000938464114053393 0.0135329245432337 1.58139040680024 0.65 21.2 21 2 neurodegeneration 5.84948823177514e-08 3.54892731135138e-06 1.57688502102588 0.648148148148148 21.2 21 2 abnormal direction of heart looping 1.80694064333337e-05 0.000525703491262195 1.57423479409979 0.647058823529412 21.2 21 2 abnormal postnatal growth/weight/body size 4.64968720123075e-05 0.00117422303685903 1.56961826977692 0.645161290322581 21.2 21 2 decreased thymus weight 4.64968720123075e-05 0.00117422303685903 1.56961826977692 0.645161290322581 21.2 21 2 lymphoid hyperplasia 0.000120081014652279 0.00256396157894887 1.564012490242 0.642857142857143 21.2 21 2 premature aging 0.000120081014652279 0.00256396157894887 1.564012490242 0.642857142857143 21.2 21 2 abnormal brainstem morphology 0.000120081014652279 0.00256396157894887 1.564012490242 0.642857142857143 21.2 21 2 midline facial cleft 0.00669004699247123 0.0616351551621192 1.564012490242 0.642857142857143 21.2 21 2 translucent skin 0.00669004699247123 0.0616351551621192 1.564012490242 0.642857142857143 21.2 21 2 amyloid beta deposits 0.00669004699247123 0.0616351551621192 1.564012490242 0.642857142857143 21.2 21 2 abnormal imprinting 0.00669004699247123 0.0616351551621192 1.564012490242 0.642857142857143 21.2 21 2 abnormal pancreas development 0.00669004699247123 0.0616351551621192 1.564012490242 0.642857142857143 21.2 21 2 abnormal maternal decidual layer morphology 0.00669004699247123 0.0616351551621192 1.564012490242 0.642857142857143 21.2 21 2 lysosomal protein accumulation 0.00669004699247123 0.0616351551621192 1.564012490242 0.642857142857143 21.2 21 2 decreased compact bone area 0.00669004699247123 0.0616351551621192 1.564012490242 0.642857142857143 21.2 21 2 testis degeneration 0.00669004699247123 0.0616351551621192 1.564012490242 0.642857142857143 21.2 21 2 multiple persisting craniopharyngeal ducts 0.00669004699247123 0.0616351551621192 1.564012490242 0.642857142857143 21.2 21 2 embryonic lethality between implantation and somite formation, complete penetrance 6.69217739119977e-30 4.75622607445983e-27 1.55904737122536 0.640816326530612 21.2 21 2 abnormal keratinocyte physiology 0.000311476357113789 0.00553426741657535 1.5570613236187 0.64 21.2 21 2 abnormal axon morphology 7.15681346092405e-14 1.1868382322699e-11 1.55435809215408 0.638888888888889 21.2 21 2 hydrops fetalis 1.00743160776703e-09 9.11267681571082e-08 1.55435809215408 0.638888888888889 21.2 21 2 abnormal lysosome morphology 1.58696460715754e-05 0.000475611380759565 1.55435809215408 0.638888888888889 21.2 21 2 abnormal tail movements 0.000812296089215103 0.0120425859082452 1.54821438427996 0.636363636363636 21.2 21 2 abnormal thrombopoiesis 0.0182975498100055 0.127315119307381 1.54821438427996 0.636363636363636 21.2 21 2 delayed hepatic development 0.0182975498100055 0.127315119307381 1.54821438427996 0.636363636363636 21.2 21 2 fatigue 0.0182975498100055 0.127315119307381 1.54821438427996 0.636363636363636 21.2 21 2 pharyngeal arch hypoplasia 0.0182975498100055 0.127315119307381 1.54821438427996 0.636363636363636 21.2 21 2 common atrioventricular valve 0.0182975498100055 0.127315119307381 1.54821438427996 0.636363636363636 21.2 21 2 abnormal placenta vasculature 2.92174472219302e-07 1.54634893541599e-05 1.54396104805941 0.634615384615385 21.2 21 2 decreased hair follicle number 1.38299519870037e-05 0.000422110497762844 1.53657367462372 0.631578947368421 21.2 21 2 maternal imprinting 0.00213276641672081 0.0258792998126489 1.53657367462372 0.631578947368421 21.2 21 2 abnormal myelin sheath morphology 1.86708250852645e-06 7.67664089249512e-05 1.53379002666244 0.630434782608696 21.2 21 2 abnormal brain commissure morphology 0.000268968848271925 0.00490153853535834 1.53183116328229 0.62962962962963 21.2 21 2 abnormal eye muscle morphology 0.000268968848271925 0.00490153853535834 1.53183116328229 0.62962962962963 21.2 21 2 embryonic lethality between somite formation and embryo turning, complete penetrance 4.8919117446889e-09 3.68746377724656e-07 1.52925665712551 0.628571428571429 21.2 21 2 small liver 6.8288697690743e-10 6.41011832097069e-08 1.52836548191739 0.628205128205128 21.2 21 2 abnormal left-right axis patterning 4.72594018551225e-06 0.000164416450509954 1.527640106748 0.627906976744186 21.2 21 2 decreased cell proliferation 2.49091507728026e-21 1.03269187578911e-18 1.52549926976157 0.627027027027027 21.2 21 2 increased fibroblast apoptosis 9.00192137880979e-05 0.00202645062713026 1.52056769884639 0.625 21.2 21 2 failure of tooth eruption 0.00564893296518374 0.0540450798111329 1.52056769884639 0.625 21.2 21 2 increased intestinal adenocarcinoma incidence 0.00564893296518374 0.0540450798111329 1.52056769884639 0.625 21.2 21 2 kidney degeneration 0.00564893296518374 0.0540450798111329 1.52056769884639 0.625 21.2 21 2 decreased fibroblast apoptosis 0.00564893296518374 0.0540450798111329 1.52056769884639 0.625 21.2 21 2 absent mammary gland 0.0514413054695422 0.249435180030188 1.52056769884639 0.625 21.2 21 2 enlarged pituitary gland 0.0514413054695422 0.249435180030188 1.52056769884639 0.625 21.2 21 2 poor grooming 0.0514413054695422 0.249435180030188 1.52056769884639 0.625 21.2 21 2 abnormal urination 0.0514413054695422 0.249435180030188 1.52056769884639 0.625 21.2 21 2 early eyelid opening 0.0514413054695422 0.249435180030188 1.52056769884639 0.625 21.2 21 2 abnormal neuron apoptosis 0.0514413054695422 0.249435180030188 1.52056769884639 0.625 21.2 21 2 increased cardiac output 0.0514413054695422 0.249435180030188 1.52056769884639 0.625 21.2 21 2 abnormal ovary development 0.0514413054695422 0.249435180030188 1.52056769884639 0.625 21.2 21 2 elevated level of mitotic sister chromatid exchange 0.0514413054695422 0.249435180030188 1.52056769884639 0.625 21.2 21 2 absent cochlear microphonics 0.0514413054695422 0.249435180030188 1.52056769884639 0.625 21.2 21 2 accumulation of giant lysosomes in kidney/renal tubule cells 0.0514413054695422 0.249435180030188 1.52056769884639 0.625 21.2 21 2 abnormal NK cell morphology 0.0514413054695422 0.249435180030188 1.52056769884639 0.625 21.2 21 2 abnormal vertebral body development 0.0514413054695422 0.249435180030188 1.52056769884639 0.625 21.2 21 2 ocular hypertension 0.0514413054695422 0.249435180030188 1.52056769884639 0.625 21.2 21 2 craniofacial phenotype 0.0514413054695422 0.249435180030188 1.52056769884639 0.625 21.2 21 2 abnormal epidermal lamellar body morphology 0.0514413054695422 0.249435180030188 1.52056769884639 0.625 21.2 21 2 abnormal olfactory bulb mitral cell layer morphology 0.0514413054695422 0.249435180030188 1.52056769884639 0.625 21.2 21 2 pleural effusion 0.0514413054695422 0.249435180030188 1.52056769884639 0.625 21.2 21 2 myocardial trabeculae hypoplasia 0.0514413054695422 0.249435180030188 1.52056769884639 0.625 21.2 21 2 delayed suture closure 0.0514413054695422 0.249435180030188 1.52056769884639 0.625 21.2 21 2 abnormal stomach position or orientation 0.0514413054695422 0.249435180030188 1.52056769884639 0.625 21.2 21 2 lung situs inversus 0.0514413054695422 0.249435180030188 1.52056769884639 0.625 21.2 21 2 abnormal foramen magnum morphology 0.0514413054695422 0.249435180030188 1.52056769884639 0.625 21.2 21 2 abnormal bronchus epithelium morphology 0.0514413054695422 0.249435180030188 1.52056769884639 0.625 21.2 21 2 increased aorta wall thickness 0.0514413054695422 0.249435180030188 1.52056769884639 0.625 21.2 21 2 impaired neuron differentiation 0.0514413054695422 0.249435180030188 1.52056769884639 0.625 21.2 21 2 abnormal heart echocardiography feature 0.0514413054695422 0.249435180030188 1.52056769884639 0.625 21.2 21 2 absent hypoglossal canal 0.0514413054695422 0.249435180030188 1.52056769884639 0.625 21.2 21 2 increased brain apoptosis 0.0514413054695422 0.249435180030188 1.52056769884639 0.625 21.2 21 2 blood in lymph vessels 0.000230380426227842 0.00429266899057495 1.51008102506124 0.620689655172414 21.2 21 2 increased B cell derived lymphoma incidence 1.40015814632037e-06 5.9032091338507e-05 1.50840315725562 0.62 21.2 21 2 abnormal salivary gland morphology 0.00180766566308355 0.0229416751883691 1.50608610171452 0.619047619047619 21.2 21 2 left pulmonary isomerism 0.00180766566308355 0.0229416751883691 1.50608610171452 0.619047619047619 21.2 21 2 impaired synaptic plasticity 7.71166509050275e-05 0.00177618212153941 1.50267866709525 0.617647058823529 21.2 21 2 increased embryonic tissue cell apoptosis 2.76988337641363e-09 2.19017363380359e-07 1.49717434963337 0.615384615384615 21.2 21 2 short premaxilla 0.0151374931980435 0.110911676966519 1.49717434963337 0.615384615384615 21.2 21 2 absent teeth 0.0151374931980435 0.110911676966519 1.49717434963337 0.615384615384615 21.2 21 2 abnormal grip strength 0.0151374931980435 0.110911676966519 1.49717434963337 0.615384615384615 21.2 21 2 axonal dystrophy 0.0151374931980435 0.110911676966519 1.49717434963337 0.615384615384615 21.2 21 2 axon degeneration 1.03237862884545e-06 4.54520679513817e-05 1.48677730553869 0.611111111111111 21.2 21 2 underdeveloped hair follicles 0.00472362979036324 0.0467197976283442 1.48677730553869 0.611111111111111 21.2 21 2 right pulmonary isomerism 0.00472362979036324 0.0467197976283442 1.48677730553869 0.611111111111111 21.2 21 2 blepharoptosis 0.00472362979036324 0.0467197976283442 1.48677730553869 0.611111111111111 21.2 21 2 abnormal body wall morphology 0.00472362979036324 0.0467197976283442 1.48677730553869 0.611111111111111 21.2 21 2 decreased tumor latency 0.00472362979036324 0.0467197976283442 1.48677730553869 0.611111111111111 21.2 21 2 abnormal hematopoietic stem cell physiology 0.00152058813078318 0.0198554486893605 1.48090071539822 0.608695652173913 21.2 21 2 abnormal mitotic spindle morphology 0.000499068227502282 0.00802993239556431 1.47712290745078 0.607142857142857 21.2 21 2 dextrocardia 0.000165977551884477 0.00333859007471782 1.47448988979044 0.606060606060606 21.2 21 2 persistence of hyaloid vascular system 5.57312522813194e-05 0.00137258901039388 1.4725497715144 0.605263157894737 21.2 21 2 abnormal vasculogenesis 1.88491787024658e-05 0.000545201535143995 1.47106084353511 0.604651162790698 21.2 21 2 increased grip strength 5.22382966577791e-10 4.99779857447021e-08 1.47043909338991 0.604395604395604 21.2 21 2 abnormal erythropoiesis 4.61124825272976e-11 4.98716522985447e-09 1.45974499089253 0.6 21.2 21 2 short stride length 5.43489602863127e-06 0.000185195943441374 1.45974499089253 0.6 21.2 21 2 liver hemorrhage 0.000419364911716359 0.00707234046030131 1.45974499089253 0.6 21.2 21 2 dilated vasculature 0.00392421987072193 0.0405883448167186 1.45974499089253 0.6 21.2 21 2 abnormal neuron proliferation 0.00392421987072193 0.0405883448167186 1.45974499089253 0.6 21.2 21 2 decreased muscle cell glucose uptake 0.00392421987072193 0.0405883448167186 1.45974499089253 0.6 21.2 21 2 absent incisors 0.0124294609985338 0.095133182258009 1.45974499089253 0.6 21.2 21 2 interdigital webbing 0.0124294609985338 0.095133182258009 1.45974499089253 0.6 21.2 21 2 audiogenic seizures 0.0124294609985338 0.095133182258009 1.45974499089253 0.6 21.2 21 2 fused cornea and lens 0.0412288111527729 0.215003496315561 1.45974499089253 0.6 21.2 21 2 abnormal neuron specification 0.0412288111527729 0.215003496315561 1.45974499089253 0.6 21.2 21 2 acrania 0.0412288111527729 0.215003496315561 1.45974499089253 0.6 21.2 21 2 aneurysm 0.0412288111527729 0.215003496315561 1.45974499089253 0.6 21.2 21 2 bifid ureter 0.0412288111527729 0.215003496315561 1.45974499089253 0.6 21.2 21 2 increased atrioventricular cushion size 0.0412288111527729 0.215003496315561 1.45974499089253 0.6 21.2 21 2 abnormal respiratory conducting tube morphology 0.0412288111527729 0.215003496315561 1.45974499089253 0.6 21.2 21 2 abnormal corneal endothelium morphology 0.0412288111527729 0.215003496315561 1.45974499089253 0.6 21.2 21 2 osteosclerosis 0.0412288111527729 0.215003496315561 1.45974499089253 0.6 21.2 21 2 absent inguinal lymph nodes 0.0412288111527729 0.215003496315561 1.45974499089253 0.6 21.2 21 2 abnormal spinal cord dorsal column morphology 0.0412288111527729 0.215003496315561 1.45974499089253 0.6 21.2 21 2 increased serotonin level 0.0412288111527729 0.215003496315561 1.45974499089253 0.6 21.2 21 2 umbilical hernia 0.0412288111527729 0.215003496315561 1.45974499089253 0.6 21.2 21 2 abnormal vibrissa follicle morphology 0.0412288111527729 0.215003496315561 1.45974499089253 0.6 21.2 21 2 aorta stenosis 0.0412288111527729 0.215003496315561 1.45974499089253 0.6 21.2 21 2 fusion of atlas and odontoid process 0.0412288111527729 0.215003496315561 1.45974499089253 0.6 21.2 21 2 increased compact bone area 0.0412288111527729 0.215003496315561 1.45974499089253 0.6 21.2 21 2 decreased circulating lactate level 0.0412288111527729 0.215003496315561 1.45974499089253 0.6 21.2 21 2 increased fatty acid oxidation 0.0412288111527729 0.215003496315561 1.45974499089253 0.6 21.2 21 2 prenatal lethality 5.40799736869709e-07 2.58699874127577e-05 1.45189689954365 0.596774193548387 21.2 21 2 abnormal cell morphology 1.16512479976992e-11 1.41377948264764e-09 1.45120847047796 0.596491228070175 21.2 21 2 liver hypoplasia 4.59469349564628e-06 0.000160976057329861 1.45038765120732 0.596153846153846 21.2 21 2 kinked neural tube 4.59469349564628e-06 0.000160976057329861 1.45038765120732 0.596153846153846 21.2 21 2 abnormal cell nucleus morphology 1.34669990073293e-05 0.000416138633922133 1.44939218953868 0.595744680851064 21.2 21 2 disheveled coat 3.96632877634683e-05 0.00103311443258248 1.44815971318704 0.595238095238095 21.2 21 2 abnormal placenta morphology 1.88801343651846e-08 1.28669408858621e-06 1.44742646776264 0.594936708860759 21.2 21 2 abnormal vertebral body morphology 0.000351033103554138 0.00604287090028317 1.44453931390407 0.59375 21.2 21 2 abnormal embryonic hematopoiesis 0.000351033103554138 0.00604287090028317 1.44453931390407 0.59375 21.2 21 2 bradykinesia 0.000351033103554138 0.00604287090028317 1.44453931390407 0.59375 21.2 21 2 abnormal apoptosis 3.87501161052812e-06 0.00014386703554013 1.44172344779509 0.592592592592593 21.2 21 2 abnormal neuronal precursor proliferation 3.87501161052812e-06 0.00014386703554013 1.44172344779509 0.592592592592593 21.2 21 2 decreased susceptibility to pharmacologically induced seizures 0.00105953023665339 0.0147651622614863 1.44172344779509 0.592592592592593 21.2 21 2 abnormal skin appearance 0.00105953023665339 0.0147651622614863 1.44172344779509 0.592592592592593 21.2 21 2 decreased circulating fructosamine level 0.00105953023665339 0.0147651622614863 1.44172344779509 0.592592592592593 21.2 21 2 increased T cell derived lymphoma incidence 1.13370054415332e-05 0.000361548731228384 1.43988451482597 0.591836734693878 21.2 21 2 cleft upper lip 0.00324542171422685 0.0354856550072057 1.43762764254568 0.590909090909091 21.2 21 2 abnormal cerebral cortex pyramidal cell morphology 0.00324542171422685 0.0354856550072057 1.43762764254568 0.590909090909091 21.2 21 2 increased bone volume 0.00324542171422685 0.0354856550072057 1.43762764254568 0.590909090909091 21.2 21 2 pale yolk sac 1.35100259815448e-08 9.46653228988529e-07 1.43629527216333 0.590361445783133 21.2 21 2 abnormal adipose tissue morphology 0.0101615909657072 0.0803718840292424 1.43112254009072 0.588235294117647 21.2 21 2 abnormal interatrial septum morphology 0.0101615909657072 0.0803718840292424 1.43112254009072 0.588235294117647 21.2 21 2 abnormal cranial suture morphology 0.0101615909657072 0.0803718840292424 1.43112254009072 0.588235294117647 21.2 21 2 abnormal glutamate-mediated receptor currents 0.0101615909657072 0.0803718840292424 1.43112254009072 0.588235294117647 21.2 21 2 abnormal ectoplacental cone morphology 0.0101615909657072 0.0803718840292424 1.43112254009072 0.588235294117647 21.2 21 2 delayed heart development 0.0101615909657072 0.0803718840292424 1.43112254009072 0.588235294117647 21.2 21 2 decreased birth body size 4.17720180414617e-11 4.61812866125049e-09 1.42986716944152 0.587719298245614 21.2 21 2 atrial septal defect 2.79166091154786e-05 0.000763105111810472 1.428011404134 0.58695652173913 21.2 21 2 abnormal embryonic neuroepithelium morphology 2.73916148564936e-06 0.000108153399929409 1.42618763478006 0.586206896551724 21.2 21 2 decreased embryo size 2.0980881990207e-41 2.0875977580256e-38 1.42513457967193 0.585774058577406 21.2 21 2 embryonic lethality before implantation, complete penetrance 8.77147589249147e-12 1.09095231412863e-09 1.42081845780206 0.584 21.2 21 2 absent mesoderm 2.29686515370351e-06 9.21524527393143e-05 1.41919651892329 0.583333333333333 21.2 21 2 abnormal digestive system morphology 0.00267546497985882 0.0314667571508218 1.41919651892329 0.583333333333333 21.2 21 2 abnormal mineral level 0.0329890280468638 0.182965902489574 1.41919651892329 0.583333333333333 21.2 21 2 mesocardia 0.0329890280468638 0.182965902489574 1.41919651892329 0.583333333333333 21.2 21 2 abnormal mating frequency 0.0329890280468638 0.182965902489574 1.41919651892329 0.583333333333333 21.2 21 2 myocarditis 0.0329890280468638 0.182965902489574 1.41919651892329 0.583333333333333 21.2 21 2 abnormal respiratory function 0.0329890280468638 0.182965902489574 1.41919651892329 0.583333333333333 21.2 21 2 abnormal AMPA-mediated synaptic currents 0.0329890280468638 0.182965902489574 1.41919651892329 0.583333333333333 21.2 21 2 dilated bile duct 0.0329890280468638 0.182965902489574 1.41919651892329 0.583333333333333 21.2 21 2 delayed somite formation 0.0329890280468638 0.182965902489574 1.41919651892329 0.583333333333333 21.2 21 2 abnormal rostral-caudal body axis extension 0.0329890280468638 0.182965902489574 1.41919651892329 0.583333333333333 21.2 21 2 abnormal thymus corticomedullary boundary morphology 0.0329890280468638 0.182965902489574 1.41919651892329 0.583333333333333 21.2 21 2 decreased keratinocyte proliferation 0.0329890280468638 0.182965902489574 1.41919651892329 0.583333333333333 21.2 21 2 reduced cerebellar foliation 0.0329890280468638 0.182965902489574 1.41919651892329 0.583333333333333 21.2 21 2 persistent right dorsal aorta 0.0329890280468638 0.182965902489574 1.41919651892329 0.583333333333333 21.2 21 2 embryonic lethality between implantation and placentation, incomplete penetrance 0.0329890280468638 0.182965902489574 1.41919651892329 0.583333333333333 21.2 21 2 lethality throughout fetal growth and development, incomplete penetrance 6.0546041788089e-16 1.30963720824236e-13 1.41353332451418 0.581005586592179 21.2 21 2 lethality throughout fetal growth and development, complete penetrance 1.26694318948898e-16 3.00144874652747e-14 1.40852586840507 0.578947368421053 21.2 21 2 shiny skin 0.00828606692912158 0.0711972072061829 1.40852586840507 0.578947368421053 21.2 21 2 abnormal stationary movement 0.00828606692912158 0.0711972072061829 1.40852586840507 0.578947368421053 21.2 21 2 increased liver cholesterol level 0.00828606692912158 0.0711972072061829 1.40852586840507 0.578947368421053 21.2 21 2 increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 0.00828606692912158 0.0711972072061829 1.40852586840507 0.578947368421053 21.2 21 2 decreased susceptibility to weight gain 0.00828606692912158 0.0711972072061829 1.40852586840507 0.578947368421053 21.2 21 2 embryonic lethality between implantation and somite formation, incomplete penetrance 0.00828606692912158 0.0711972072061829 1.40852586840507 0.578947368421053 21.2 21 2 trabecula carnea hypoplasia 5.70693323817844e-05 0.00138770307494572 1.40568036160022 0.577777777777778 21.2 21 2 abnormal myocardial trabeculae morphology 5.70693323817844e-05 0.00138770307494572 1.40568036160022 0.577777777777778 21.2 21 2 embryonic growth arrest 2.01683906554594e-19 7.16698167935076e-17 1.40237510042077 0.576419213973799 21.2 21 2 abnormal locomotor coordination 0.000602179923677254 0.00933285084203843 1.40076539530091 0.575757575757576 21.2 21 2 myeloid hyperplasia 0.000602179923677254 0.00933285084203843 1.40076539530091 0.575757575757576 21.2 21 2 abnormal optic nerve morphology 0.0001390219083994 0.00289386608488292 1.39023332465955 0.571428571428571 21.2 21 2 decreased glycogen level 0.000496929313999626 0.00802669914658487 1.39023332465955 0.571428571428571 21.2 21 2 small superior cervical ganglion 0.00180681291552153 0.0229416751883691 1.39023332465955 0.571428571428571 21.2 21 2 absent corpus callosum 0.00180681291552153 0.0229416751883691 1.39023332465955 0.571428571428571 21.2 21 2 failure of blastocyst to hatch from the zona pellucida 0.00180681291552153 0.0229416751883691 1.39023332465955 0.571428571428571 21.2 21 2 liver degeneration 0.0067462921475731 0.0619239915759708 1.39023332465955 0.571428571428571 21.2 21 2 megacephaly 0.0264007548054733 0.158459302253348 1.39023332465955 0.571428571428571 21.2 21 2 abnormal fluid regulation 0.0264007548054733 0.158459302253348 1.39023332465955 0.571428571428571 21.2 21 2 increased lactate dehydrogenase level 0.0264007548054733 0.158459302253348 1.39023332465955 0.571428571428571 21.2 21 2 failure of zygotic cell division 0.0264007548054733 0.158459302253348 1.39023332465955 0.571428571428571 21.2 21 2 vascular smooth muscle hypoplasia 0.0264007548054733 0.158459302253348 1.39023332465955 0.571428571428571 21.2 21 2 spina bifida occulta 0.0264007548054733 0.158459302253348 1.39023332465955 0.571428571428571 21.2 21 2 increased pulmonary respiratory rate 0.0264007548054733 0.158459302253348 1.39023332465955 0.571428571428571 21.2 21 2 pulmonary alveolar hemorrhage 0.0264007548054733 0.158459302253348 1.39023332465955 0.571428571428571 21.2 21 2 abnormal nervous system morphology 2.25548190890543e-07 1.24678027742272e-05 1.38583385211316 0.569620253164557 21.2 21 2 increased lung adenocarcinoma incidence 3.26233784846567e-05 0.000867921432947419 1.38341845542103 0.568627450980392 21.2 21 2 small lung 3.26233784846567e-05 0.000867921432947419 1.38341845542103 0.568627450980392 21.2 21 2 malocclusion 0.000409549831366594 0.00695396044726555 1.38083985624969 0.567567567567568 21.2 21 2 delayed eyelid opening 0.00148169806769647 0.0194497305720051 1.37864804695406 0.566666666666667 21.2 21 2 abnormal optic cup morphology 0.00148169806769647 0.0194497305720051 1.37864804695406 0.566666666666667 21.2 21 2 abnormal vitelline vasculature morphology 7.95023349340342e-10 7.32452067216334e-08 1.37512209286978 0.565217391304348 21.2 21 2 abnormal allantois morphology 9.49678726279819e-05 0.00212822146992887 1.37512209286978 0.565217391304348 21.2 21 2 conjunctivitis 0.00548770537270365 0.0532189751056543 1.37512209286978 0.565217391304348 21.2 21 2 abnormal Wolffian duct morphology 0.00548770537270365 0.0532189751056543 1.37512209286978 0.565217391304348 21.2 21 2 dilated heart 0.00548770537270365 0.0532189751056543 1.37512209286978 0.565217391304348 21.2 21 2 abnormal corneal stroma morphology 0.00548770537270365 0.0532189751056543 1.37512209286978 0.565217391304348 21.2 21 2 abnormal brain morphology 3.61875049926067e-13 5.45554052540056e-11 1.37512209286978 0.565217391304348 21.2 21 2 embryonic lethality during organogenesis, complete penetrance 5.79276090920012e-42 7.20474638081765e-39 1.37285540810131 0.564285714285714 21.2 21 2 increased hepatocyte apoptosis 0.000337185084100682 0.00588595015228383 1.37240982049725 0.564102564102564 21.2 21 2 abnormal posture 3.70221705048433e-07 1.84185298261595e-05 1.36851092896175 0.5625 21.2 21 2 intraventricular hemorrhage 0.0211472827556982 0.144113204552146 1.36851092896175 0.5625 21.2 21 2 small pancreas 0.0211472827556982 0.144113204552146 1.36851092896175 0.5625 21.2 21 2 abnormal amnion morphology 0.0211472827556982 0.144113204552146 1.36851092896175 0.5625 21.2 21 2 decreased circulating triiodothyronine level 0.0211472827556982 0.144113204552146 1.36851092896175 0.5625 21.2 21 2 embryonic lethality between somite formation and embryo turning, incomplete penetrance 0.0211472827556982 0.144113204552146 1.36851092896175 0.5625 21.2 21 2 decreased adipocyte glucose uptake 0.0211472827556982 0.144113204552146 1.36851092896175 0.5625 21.2 21 2 increased circulating alkaline phosphatase level 5.89960539666439e-13 8.63251083776628e-11 1.3666336848891 0.561728395061728 21.2 21 2 astrocytosis 1.2740080286546e-06 5.51146951526664e-05 1.36642795951127 0.561643835616438 21.2 21 2 abnormal developmental patterning 3.07096692249745e-07 1.58447968595837e-05 1.36480222725725 0.560975609756098 21.2 21 2 hemopericardium 0.000277372161375368 0.00501791455579075 1.36480222725725 0.560975609756098 21.2 21 2 palatal shelves fail to meet at midline 0.000277372161375368 0.00501791455579075 1.36480222725725 0.560975609756098 21.2 21 2 double outlet right ventricle 5.3015981487246e-09 3.93663444625446e-07 1.36424765503975 0.560747663551402 21.2 21 2 mandible hypoplasia 0.00446172405866723 0.0451160105525803 1.36242865816636 0.56 21.2 21 2 spontaneous skin ulceration 0.00446172405866723 0.0451160105525803 1.36242865816636 0.56 21.2 21 2 abnormal egg cylinder morphology 0.00446172405866723 0.0451160105525803 1.36242865816636 0.56 21.2 21 2 abnormal preimplantation embryo development 0.00446172405866723 0.0451160105525803 1.36242865816636 0.56 21.2 21 2 pericardial edema 3.63995346814871e-06 0.00013718764018212 1.35956641308618 0.558823529411765 21.2 21 2 abnormal embryo size 3.03224874917128e-09 2.35709961361361e-07 1.35640021277625 0.557522123893805 21.2 21 2 thin ventricular wall 1.44637899956406e-07 8.27096037107035e-06 1.3516157323079 0.555555555555556 21.2 21 2 increased neuron apoptosis 5.98273094717928e-07 2.83467490116352e-05 1.3516157323079 0.555555555555556 21.2 21 2 abnormal maxilla morphology 4.38865600893139e-05 0.00112544142497081 1.3516157323079 0.555555555555556 21.2 21 2 abnormal cell adhesion 4.38865600893139e-05 0.00112544142497081 1.3516157323079 0.555555555555556 21.2 21 2 reduced long term depression 0.000813328415109622 0.0120425859082452 1.3516157323079 0.555555555555556 21.2 21 2 abnormal trigeminal nerve morphology 0.00362673819911343 0.0382267426707401 1.3516157323079 0.555555555555556 21.2 21 2 abnormal trigeminal ganglion morphology 0.00362673819911343 0.0382267426707401 1.3516157323079 0.555555555555556 21.2 21 2 eye inflammation 0.0169590424348872 0.120015983091841 1.3516157323079 0.555555555555556 21.2 21 2 abnormal bile duct morphology 0.0169590424348872 0.120015983091841 1.3516157323079 0.555555555555556 21.2 21 2 abnormal metacarpal bone morphology 0.0169590424348872 0.120015983091841 1.3516157323079 0.555555555555556 21.2 21 2 abnormal redox activity 0.0169590424348872 0.120015983091841 1.3516157323079 0.555555555555556 21.2 21 2 darkened coat color 0.0169590424348872 0.120015983091841 1.3516157323079 0.555555555555556 21.2 21 2 abnormal pregnancy 0.0169590424348872 0.120015983091841 1.3516157323079 0.555555555555556 21.2 21 2 small thoracic cage 0.0169590424348872 0.120015983091841 1.3516157323079 0.555555555555556 21.2 21 2 abnormal vagina epithelium morphology 0.0884713421143169 0.323160739367641 1.3516157323079 0.555555555555556 21.2 21 2 abnormal kindling response 0.0884713421143169 0.323160739367641 1.3516157323079 0.555555555555556 21.2 21 2 multifocal hepatic necrosis 0.0884713421143169 0.323160739367641 1.3516157323079 0.555555555555556 21.2 21 2 decreased level of surface class I molecules 0.0884713421143169 0.323160739367641 1.3516157323079 0.555555555555556 21.2 21 2 abnormal germ cell morphology 0.0884713421143169 0.323160739367641 1.3516157323079 0.555555555555556 21.2 21 2 abnormal posterior semicircular canal morphology 0.0884713421143169 0.323160739367641 1.3516157323079 0.555555555555556 21.2 21 2 polycythemia 0.0884713421143169 0.323160739367641 1.3516157323079 0.555555555555556 21.2 21 2 genetic imprinting 0.0884713421143169 0.323160739367641 1.3516157323079 0.555555555555556 21.2 21 2 decreased cochlear hair cell number 0.0884713421143169 0.323160739367641 1.3516157323079 0.555555555555556 21.2 21 2 positive geotaxis 0.0884713421143169 0.323160739367641 1.3516157323079 0.555555555555556 21.2 21 2 absent cervical lymph nodes 0.0884713421143169 0.323160739367641 1.3516157323079 0.555555555555556 21.2 21 2 abnormal optic chiasm morphology 0.0884713421143169 0.323160739367641 1.3516157323079 0.555555555555556 21.2 21 2 eye opacity 0.0884713421143169 0.323160739367641 1.3516157323079 0.555555555555556 21.2 21 2 abnormal hippocampus granule cell morphology 0.0884713421143169 0.323160739367641 1.3516157323079 0.555555555555556 21.2 21 2 abnormal cerebellar layer morphology 0.0884713421143169 0.323160739367641 1.3516157323079 0.555555555555556 21.2 21 2 axonal spheroids 0.0884713421143169 0.323160739367641 1.3516157323079 0.555555555555556 21.2 21 2 abnormal telomere morphology 0.0884713421143169 0.323160739367641 1.3516157323079 0.555555555555556 21.2 21 2 shortened ST segment 0.0884713421143169 0.323160739367641 1.3516157323079 0.555555555555556 21.2 21 2 fusion of atlas and occipital bones 0.0884713421143169 0.323160739367641 1.3516157323079 0.555555555555556 21.2 21 2 decreased effector memory CD4-positive, alpha-beta T cell number 0.0884713421143169 0.323160739367641 1.3516157323079 0.555555555555556 21.2 21 2 abnormal pulmonary alveolar system morphology 0.0884713421143169 0.323160739367641 1.3516157323079 0.555555555555556 21.2 21 2 abnormal ureteric bud invasion 0.0884713421143169 0.323160739367641 1.3516157323079 0.555555555555556 21.2 21 2 increased core body temperature 0.0884713421143169 0.323160739367641 1.3516157323079 0.555555555555556 21.2 21 2 increased myeloid cell number 0.0884713421143169 0.323160739367641 1.3516157323079 0.555555555555556 21.2 21 2 trigeminal neuroma 0.0884713421143169 0.323160739367641 1.3516157323079 0.555555555555556 21.2 21 2 abnormal coronary sinus connection 0.0884713421143169 0.323160739367641 1.3516157323079 0.555555555555556 21.2 21 2 increased cardiac muscle glycogen level 0.0884713421143169 0.323160739367641 1.3516157323079 0.555555555555556 21.2 21 2 decreased fatty acid oxidation 0.0884713421143169 0.323160739367641 1.3516157323079 0.555555555555556 21.2 21 2 increased bone mineralization 0.0884713421143169 0.323160739367641 1.3516157323079 0.555555555555556 21.2 21 2 increased cellular sensitivity to gamma-irradiation 0.000153832231510317 0.00318881396568262 1.34586417600021 0.553191489361702 21.2 21 2 incomplete somite formation 0.000665307084341147 0.0102473769182576 1.34450196529575 0.552631578947368 21.2 21 2 embryonic lethality, complete penetrance 1.72143480284917e-22 7.78558013106785e-20 1.34229424449888 0.551724137931034 21.2 21 2 absent long term depression 0.00294786354470771 0.0337917537670988 1.34229424449888 0.551724137931034 21.2 21 2 abnormal embryonic erythropoiesis 0.00294786354470771 0.0337917537670988 1.34229424449888 0.551724137931034 21.2 21 2 ventricular septal defect 1.99108014387783e-10 2.01466604209616e-08 1.34167738133505 0.551470588235294 21.2 21 2 preweaning lethality, complete penetrance 2.16811872729661e-50 5.39319533415031e-47 1.34138728892827 0.551351351351351 21.2 21 2 muscular ventricular septal defect 2.44637236551725e-05 0.000679927514997112 1.33809957498482 0.55 21.2 21 2 abnormal basioccipital bone morphology 0.0136172133338323 0.101720174678402 1.33809957498482 0.55 21.2 21 2 abnormal vascular regression 0.0136172133338323 0.101720174678402 1.33809957498482 0.55 21.2 21 2 abnormal dopamine level 0.0136172133338323 0.101720174678402 1.33809957498482 0.55 21.2 21 2 abnormal sperm mitochondrial sheath morphology 0.0136172133338323 0.101720174678402 1.33809957498482 0.55 21.2 21 2 abnormal extraembryonic tissue morphology 4.61975264525221e-08 2.87290867626622e-06 1.33571437075134 0.549019607843137 21.2 21 2 abnormal trophoblast layer morphology 0.000103623757663363 0.00228109820520013 1.33571437075134 0.549019607843137 21.2 21 2 failure of chorioallantoic fusion 0.000103623757663363 0.00228109820520013 1.33571437075134 0.549019607843137 21.2 21 2 abnormal dendritic spine morphology 0.000103623757663363 0.00228109820520013 1.33571437075134 0.549019607843137 21.2 21 2 pericardial effusion 2.01193366201235e-05 0.000575251147615601 1.33417552931038 0.548387096774194 21.2 21 2 osteopetrosis 0.0023962207769113 0.0287257791930934 1.33417552931038 0.548387096774194 21.2 21 2 decreased neuronal precursor cell number 0.0023962207769113 0.0287257791930934 1.33417552931038 0.548387096774194 21.2 21 2 decreased bone marrow cell number 3.95686076088151e-06 0.000145817646558411 1.33310044830368 0.547945205479452 21.2 21 2 abnormal mesoderm development 8.50121784145876e-05 0.00194007150280997 1.33121398540514 0.547169811320755 21.2 21 2 atrioventricular septal defect 8.50121784145876e-05 0.00194007150280997 1.33121398540514 0.547169811320755 21.2 21 2 edema 2.18448661755591e-12 3.08876495927886e-10 1.32961268550289 0.546511627906977 21.2 21 2 abnormal neuron morphology 1.06755587743295e-07 6.17568661654528e-06 1.32704090081139 0.545454545454545 21.2 21 2 abnormal suckling behavior 5.33475423843542e-07 2.57673809089478e-05 1.32704090081139 0.545454545454545 21.2 21 2 abnormal vascular development 1.35971178813225e-05 0.000417565811478886 1.32704090081139 0.545454545454545 21.2 21 2 abnormal enterocyte morphology 0.0109473366675886 0.0852316117703494 1.32704090081139 0.545454545454545 21.2 21 2 intracerebral hemorrhage 0.0109473366675886 0.0852316117703494 1.32704090081139 0.545454545454545 21.2 21 2 testis hypoplasia 0.0109473366675886 0.0852316117703494 1.32704090081139 0.545454545454545 21.2 21 2 increased skin papilloma incidence 0.0109473366675886 0.0852316117703494 1.32704090081139 0.545454545454545 21.2 21 2 premature suture closure 0.0687463247640938 0.304617314226851 1.32704090081139 0.545454545454545 21.2 21 2 abnormal sebaceous gland morphology 0.0687463247640938 0.304617314226851 1.32704090081139 0.545454545454545 21.2 21 2 abnormal enteric ganglia morphology 0.0687463247640938 0.304617314226851 1.32704090081139 0.545454545454545 21.2 21 2 abnormal glossopharyngeal ganglion morphology 0.0687463247640938 0.304617314226851 1.32704090081139 0.545454545454545 21.2 21 2 abnormal eye distance/ position 0.0687463247640938 0.304617314226851 1.32704090081139 0.545454545454545 21.2 21 2 abnormal hemoglobin 0.0687463247640938 0.304617314226851 1.32704090081139 0.545454545454545 21.2 21 2 failure of somite differentiation 0.0687463247640938 0.304617314226851 1.32704090081139 0.545454545454545 21.2 21 2 abnormal proximal-distal axis patterning 0.0687463247640938 0.304617314226851 1.32704090081139 0.545454545454545 21.2 21 2 abnormal fear/anxiety-related behavior 0.0687463247640938 0.304617314226851 1.32704090081139 0.545454545454545 21.2 21 2 retinal detachment 0.0687463247640938 0.304617314226851 1.32704090081139 0.545454545454545 21.2 21 2 abnormal radial glial cell morphology 0.0687463247640938 0.304617314226851 1.32704090081139 0.545454545454545 21.2 21 2 abnormal crista ampullaris neuroepithelium morphology 0.0687463247640938 0.304617314226851 1.32704090081139 0.545454545454545 21.2 21 2 abnormal spinal cord ventral horn morphology 0.0687463247640938 0.304617314226851 1.32704090081139 0.545454545454545 21.2 21 2 abnormal dorsal-ventral polarity of the somites 0.0687463247640938 0.304617314226851 1.32704090081139 0.545454545454545 21.2 21 2 increased glycogen level 0.0687463247640938 0.304617314226851 1.32704090081139 0.545454545454545 21.2 21 2 increased circulating triiodothyronine level 0.0687463247640938 0.304617314226851 1.32704090081139 0.545454545454545 21.2 21 2 hypolactation 0.0687463247640938 0.304617314226851 1.32704090081139 0.545454545454545 21.2 21 2 thin hypoglossal nerve 0.0687463247640938 0.304617314226851 1.32704090081139 0.545454545454545 21.2 21 2 reduced sympathetic cervical ganglion size 0.0687463247640938 0.304617314226851 1.32704090081139 0.545454545454545 21.2 21 2 abnormal embryo turning 6.9728164739307e-05 0.00165189342656215 1.32704090081139 0.545454545454545 21.2 21 2 abnormal heart development 2.46227168583203e-11 2.78404582659417e-09 1.32424123646369 0.544303797468354 21.2 21 2 abnormal myocardium layer morphology 2.20753178314152e-06 8.92883790335697e-05 1.32424123646369 0.544303797468354 21.2 21 2 incomplete embryo turning 5.7181734746507e-05 0.00138770307494572 1.32316066425931 0.543859649122807 21.2 21 2 abnormal neural tube morphology 1.67961138704894e-11 1.98953967870678e-09 1.3215798271455 0.54320987654321 21.2 21 2 increased carcinoma incidence 0.00158406802813493 0.0204164208289411 1.32072165842658 0.542857142857143 21.2 21 2 abnormal embryonic epiblast morphology 0.00158406802813493 0.0204164208289411 1.32072165842658 0.542857142857143 21.2 21 2 decreased circulating thyroxine level 0.00158406802813493 0.0204164208289411 1.32072165842658 0.542857142857143 21.2 21 2 curly tail 0.000243001198309316 0.00451093642383898 1.3178253390002 0.541666666666667 21.2 21 2 abnormal sensory capabilities/reflexes/nociception 0.0088112622006112 0.0742174080413239 1.3178253390002 0.541666666666667 21.2 21 2 abnormal lung development 1.22930658248481e-06 5.36473705952803e-05 1.31663273688346 0.541176470588235 21.2 21 2 abnormal hepatocyte morphology 3.34684089701034e-08 2.19085966613506e-06 1.31508557738066 0.540540540540541 21.2 21 2 abnormal breathing pattern 0.00128836204304259 0.0174558977651648 1.31508557738066 0.540540540540541 21.2 21 2 decreased circulating alkaline phosphatase level 0.000198628835228874 0.0037716734933727 1.31377049180328 0.54 21.2 21 2 perinatal lethality, incomplete penetrance 4.26059732652338e-15 8.15248911517454e-13 1.31333988856113 0.539823008849557 21.2 21 2 gliosis 3.15112720358528e-05 0.000852003143360694 1.31299813995625 0.53968253968254 21.2 21 2 anophthalmia 8.31415171893698e-07 3.7947619084139e-05 1.31213032889216 0.539325842696629 21.2 21 2 distended pericardium 0.000162360346059495 0.00331042099035242 1.3100275559292 0.538461538461538 21.2 21 2 failure of heart looping 0.00104811608462169 0.0147651622614863 1.3100275559292 0.538461538461538 21.2 21 2 abnormal nasal bone morphology 0.00709980531492631 0.0635988064661367 1.3100275559292 0.538461538461538 21.2 21 2 no spontaneous movement 0.00709980531492631 0.0635988064661367 1.3100275559292 0.538461538461538 21.2 21 2 heart inflammation 0.00709980531492631 0.0635988064661367 1.3100275559292 0.538461538461538 21.2 21 2 decreased Peyer's patch number 0.00709980531492631 0.0635988064661367 1.3100275559292 0.538461538461538 21.2 21 2 increased foot pad pigmentation 0.0538158187038208 0.257932271725924 1.3100275559292 0.538461538461538 21.2 21 2 increased pituitary adenoma incidence 0.0538158187038208 0.257932271725924 1.3100275559292 0.538461538461538 21.2 21 2 abnormal tail bud morphology 0.0538158187038208 0.257932271725924 1.3100275559292 0.538461538461538 21.2 21 2 abnormal bile duct development 0.0538158187038208 0.257932271725924 1.3100275559292 0.538461538461538 21.2 21 2 small otic vesicle 0.0538158187038208 0.257932271725924 1.3100275559292 0.538461538461538 21.2 21 2 abnormal vertebral arch development 0.0538158187038208 0.257932271725924 1.3100275559292 0.538461538461538 21.2 21 2 abnormal aorta tunica media morphology 0.0538158187038208 0.257932271725924 1.3100275559292 0.538461538461538 21.2 21 2 impaired limb coordination 0.000132717895671905 0.0028216732092638 1.3065618745643 0.537037037037037 21.2 21 2 abnormal embryo development 1.74092544685379e-09 1.41985313083567e-07 1.30589931783278 0.536764705882353 21.2 21 2 thick ventricular wall 0.000852890455901091 0.0124797941709057 1.30546299998519 0.536585365853659 21.2 21 2 abnormal somite shape 0.00572665198787332 0.0543704077092935 1.30334374186833 0.535714285714286 21.2 21 2 straub tail 0.00572665198787332 0.0543704077092935 1.30334374186833 0.535714285714286 21.2 21 2 corneal vascularization 0.00572665198787332 0.0543704077092935 1.30334374186833 0.535714285714286 21.2 21 2 abnormal motor coordination/ balance 3.12118611505367e-07 1.58447968595837e-05 1.30246606931489 0.535353535353535 21.2 21 2 decreased circulating serum albumin level 3.12118611505367e-07 1.58447968595837e-05 1.30246606931489 0.535353535353535 21.2 21 2 abnormal double-strand DNA break repair 0.000694211597602033 0.0104999383240499 1.30132305389644 0.534883720930233 21.2 21 2 cleft palate 4.78786319447397e-09 3.66455682961661e-07 1.30002734557859 0.534351145038168 21.2 21 2 seminiferous tubule degeneration 1.16556865908873e-05 0.000369184500474228 1.29977293709609 0.534246575342466 21.2 21 2 abnormal spatial learning 7.48688286167977e-11 7.92494515677806e-09 1.29854615754244 0.533742331288344 21.2 21 2 abnormal fontanelle morphology 0.0423679477276899 0.218652012391346 1.29755110301558 0.533333333333333 21.2 21 2 decreased hepatocyte number 0.0423679477276899 0.218652012391346 1.29755110301558 0.533333333333333 21.2 21 2 abnormal pup retrieval 0.0423679477276899 0.218652012391346 1.29755110301558 0.533333333333333 21.2 21 2 absent egg cylinders 0.0423679477276899 0.218652012391346 1.29755110301558 0.533333333333333 21.2 21 2 abnormal glial cell morphology 0.0423679477276899 0.218652012391346 1.29755110301558 0.533333333333333 21.2 21 2 abnormal placenta size 0.0423679477276899 0.218652012391346 1.29755110301558 0.533333333333333 21.2 21 2 abnormal olfactory nerve morphology 0.0423679477276899 0.218652012391346 1.29755110301558 0.533333333333333 21.2 21 2 abnormal secondary palate development 0.0423679477276899 0.218652012391346 1.29755110301558 0.533333333333333 21.2 21 2 decreased brown adipose tissue mass 0.0423679477276899 0.218652012391346 1.29755110301558 0.533333333333333 21.2 21 2 pulmonary hypoplasia 0.000460292319594888 0.00753274437494924 1.29410016923097 0.531914893617021 21.2 21 2 neuron degeneration 0.000460292319594888 0.00753274437494924 1.29410016923097 0.531914893617021 21.2 21 2 pallor 2.32902465847621e-11 2.69462736649283e-09 1.29291699193339 0.531428571428571 21.2 21 2 increased fatty acid level 0.00373612125069141 0.0389668830653874 1.29248254401943 0.53125 21.2 21 2 decreased startle reflex 5.32527199905022e-08 3.27076891299689e-06 1.28923346773984 0.52991452991453 21.2 21 2 decreased mean corpuscular hemoglobin 3.24185457796625e-05 0.000867921432947419 1.28801028608165 0.529411764705882 21.2 21 2 abnormal brown adipose tissue morphology 0.00302153848396415 0.0342418085597304 1.28801028608165 0.529411764705882 21.2 21 2 abnormal nervous system development 0.00302153848396415 0.0342418085597304 1.28801028608165 0.529411764705882 21.2 21 2 hyperlipidemia 0.0335061860194381 0.183785309202541 1.28801028608165 0.529411764705882 21.2 21 2 absence seizures 0.0335061860194381 0.183785309202541 1.28801028608165 0.529411764705882 21.2 21 2 abnormal involuntary movement 0.0335061860194381 0.183785309202541 1.28801028608165 0.529411764705882 21.2 21 2 abnormal embryonic-extraembryonic boundary morphology 0.0335061860194381 0.183785309202541 1.28801028608165 0.529411764705882 21.2 21 2 increased regulatory T cell number 0.0335061860194381 0.183785309202541 1.28801028608165 0.529411764705882 21.2 21 2 decreased growth hormone level 0.0335061860194381 0.183785309202541 1.28801028608165 0.529411764705882 21.2 21 2 enhanced behavioral response to cocaine 0.0335061860194381 0.183785309202541 1.28801028608165 0.529411764705882 21.2 21 2 increased hepatoma incidence 0.0335061860194381 0.183785309202541 1.28801028608165 0.529411764705882 21.2 21 2 common atrium 0.0335061860194381 0.183785309202541 1.28801028608165 0.529411764705882 21.2 21 2 increased trabecular bone mass 0.0335061860194381 0.183785309202541 1.28801028608165 0.529411764705882 21.2 21 2 abnormal behavior 7.82065620426452e-17 2.047777085064e-14 1.28646590923982 0.528776978417266 21.2 21 2 extramedullary hematopoiesis 2.63298223976103e-07 1.42381376552295e-05 1.28531005487393 0.528301886792453 21.2 21 2 heart right ventricle hypertrophy 0.00244548288975145 0.0290364615191252 1.2840349456925 0.527777777777778 21.2 21 2 abnormal pharyngeal arch morphology 0.00244548288975145 0.0290364615191252 1.2840349456925 0.527777777777778 21.2 21 2 abnormal trophoblast giant cell morphology 0.00244548288975145 0.0290364615191252 1.2840349456925 0.527777777777778 21.2 21 2 hemorrhage 2.40158150049807e-14 4.26709570177782e-12 1.28374736787712 0.527659574468085 21.2 21 2 decreased circulating total protein level 0.00020297567248134 0.00382501504013132 1.28280620411768 0.527272727272727 21.2 21 2 pale liver 1.77399153839129e-05 0.00051997337031736 1.28220843794614 0.527027027027027 21.2 21 2 kyphosis 1.24759983565538e-09 1.08890978394547e-07 1.28133171422789 0.526666666666667 21.2 21 2 decreased birth weight 1.30603301532052e-06 5.60130538898238e-05 1.28047806218643 0.526315789473684 21.2 21 2 decreased brain weight 0.00016550311645236 0.00333859007471782 1.28047806218643 0.526315789473684 21.2 21 2 increased hepatocellular carcinoma incidence 0.00016550311645236 0.00333859007471782 1.28047806218643 0.526315789473684 21.2 21 2 decreased neuron apoptosis 0.00198064533048864 0.0246656534937509 1.28047806218643 0.526315789473684 21.2 21 2 enlarged adrenal glands 0.0265956818857379 0.158459302253348 1.28047806218643 0.526315789473684 21.2 21 2 abnormal long term depression 0.0265956818857379 0.158459302253348 1.28047806218643 0.526315789473684 21.2 21 2 increased malignant tumor incidence 0.0265956818857379 0.158459302253348 1.28047806218643 0.526315789473684 21.2 21 2 abnormal neurotransmitter level 0.0265956818857379 0.158459302253348 1.28047806218643 0.526315789473684 21.2 21 2 abnormal optic vesicle formation 0.0265956818857379 0.158459302253348 1.28047806218643 0.526315789473684 21.2 21 2 increased circulating VLDL cholesterol level 0.0265956818857379 0.158459302253348 1.28047806218643 0.526315789473684 21.2 21 2 right-sided stomach 0.0265956818857379 0.158459302253348 1.28047806218643 0.526315789473684 21.2 21 2 preweaning lethality, incomplete penetrance 1.64485354062504e-23 8.18314636460956e-21 1.27891268558229 0.525672371638142 21.2 21 2 abnormal cornea morphology 1.18732703670103e-05 0.000369184500474228 1.27883642364517 0.525641025641026 21.2 21 2 abnormal excitatory postsynaptic currents 1.18732703670103e-05 0.000369184500474228 1.27883642364517 0.525641025641026 21.2 21 2 increased mean corpuscular hemoglobin 8.77427217951813e-07 3.96836400846388e-05 1.27789123781838 0.525252525252525 21.2 21 2 decreased grip strength 3.16065481303029e-13 4.91383052963303e-11 1.27755459629103 0.525114155251142 21.2 21 2 increased tumor incidence 4.44214155094149e-08 2.79742458429543e-06 1.27531484419374 0.524193548387097 21.2 21 2 abnormal reproductive system morphology 0.0013017362956535 0.0174558977651648 1.27438054760459 0.523809523809524 21.2 21 2 spina bifida 0.0013017362956535 0.0174558977651648 1.27438054760459 0.523809523809524 21.2 21 2 abnormal anxiety-related response 0.0211752266387173 0.144113204552146 1.27438054760459 0.523809523809524 21.2 21 2 trunk curl 0.0211752266387173 0.144113204552146 1.27438054760459 0.523809523809524 21.2 21 2 increased bone mineral content 3.24742527636767e-07 1.63191320706355e-05 1.27225480857606 0.522935779816514 21.2 21 2 osteoporosis 0.00105623262284284 0.0147651622614863 1.27174752994425 0.522727272727273 21.2 21 2 lethality, incomplete penetrance 0.00105623262284284 0.0147651622614863 1.27174752994425 0.522727272727273 21.2 21 2 decreased body length 8.68375955221011e-16 1.80007099051022e-13 1.26972952370822 0.521897810218978 21.2 21 2 abnormal nervous system physiology 1.78923686879484e-07 1.01152879798345e-05 1.26934347034133 0.521739130434783 21.2 21 2 abnormal locomotor behavior 2.91962842170665e-06 0.00011259807285264 1.26934347034133 0.521739130434783 21.2 21 2 microcephaly 4.88542409201394e-05 0.00122135602300348 1.26934347034133 0.521739130434783 21.2 21 2 abnormal cell death 0.000857484108734256 0.0125102153693634 1.26934347034133 0.521739130434783 21.2 21 2 abnormal nasal cavity morphology 0.0169032980801903 0.120015983091841 1.26934347034133 0.521739130434783 21.2 21 2 abnormal palatal shelf fusion at midline 0.0169032980801903 0.120015983091841 1.26934347034133 0.521739130434783 21.2 21 2 abnormal basicranium morphology 0.0169032980801903 0.120015983091841 1.26934347034133 0.521739130434783 21.2 21 2 abnormal vertebral artery topology 0.0169032980801903 0.120015983091841 1.26934347034133 0.521739130434783 21.2 21 2 increased circulating free fatty acid level 3.98909810304094e-05 0.00103363349284524 1.26785363058741 0.52112676056338 21.2 21 2 overriding aortic valve 0.000696478320992253 0.0104999383240499 1.26713974903866 0.520833333333333 21.2 21 2 small heart 0.000696478320992253 0.0104999383240499 1.26713974903866 0.520833333333333 21.2 21 2 vertebral transformation 0.000696478320992253 0.0104999383240499 1.26713974903866 0.520833333333333 21.2 21 2 impaired coordination 2.69590524782076e-19 8.94141907193884e-17 1.26567484759468 0.520231213872832 21.2 21 2 abnormal primitive streak morphology 0.0135232618543838 0.101628742787854 1.26511232544019 0.52 21.2 21 2 abnormal cochlear outer hair cell morphology 0.0135232618543838 0.101628742787854 1.26511232544019 0.52 21.2 21 2 ataxia 7.48845211670319e-12 9.80396033699957e-10 1.2646305614168 0.51980198019802 21.2 21 2 neonatal lethality, incomplete penetrance 9.25231319252623e-15 1.70482437528956e-12 1.26324085750315 0.519230769230769 21.2 21 2 abnormal placenta labyrinth morphology 1.7761574197974e-05 0.00051997337031736 1.26264862081422 0.518987341772152 21.2 21 2 increased cell proliferation 0.000374206722598596 0.00641958084457937 1.26150801682071 0.518518518518518 21.2 21 2 thin epidermis 0.0108400314396479 0.0849278053736195 1.26150801682071 0.518518518518518 21.2 21 2 abnormal bone trabecula morphology 0.0108400314396479 0.0849278053736195 1.26150801682071 0.518518518518518 21.2 21 2 abnormal neural tube closure 1.18625325676351e-05 0.000369184500474228 1.26042238169435 0.518072289156627 21.2 21 2 decreased trophoblast giant cell number 0.00870392531983649 0.0738019459179098 1.2584008542177 0.517241379310345 21.2 21 2 short sternum 0.00870392531983649 0.0738019459179098 1.2584008542177 0.517241379310345 21.2 21 2 abnormal definitive hematopoiesis 4.3342110237422e-06 0.000157391969657792 1.25569461582153 0.516129032258065 21.2 21 2 abnormal cranial ganglia morphology 0.00699922571891711 0.0633111780938412 1.25569461582153 0.516129032258065 21.2 21 2 increased lung adenoma incidence 0.00699922571891711 0.0633111780938412 1.25569461582153 0.516129032258065 21.2 21 2 pale kidney 0.00699922571891711 0.0633111780938412 1.25569461582153 0.516129032258065 21.2 21 2 small cranium 0.00699922571891711 0.0633111780938412 1.25569461582153 0.516129032258065 21.2 21 2 abnormal mitochondrial ATP synthesis coupled electron transport 0.00699922571891711 0.0633111780938412 1.25569461582153 0.516129032258065 21.2 21 2 decreased erythrocyte cell number 2.77348620964072e-09 2.19017363380359e-07 1.25519473739167 0.515923566878981 21.2 21 2 increased sacral vertebrae number 0.000133868792379338 0.00283403081739236 1.25446835154827 0.515625 21.2 21 2 enlarged pericardium 0.00563590814338082 0.0540450798111329 1.25331640632187 0.515151515151515 21.2 21 2 prenatal lethality, complete penetrance 4.14738717526881e-15 8.15248911517454e-13 1.25146003415847 0.514388489208633 21.2 21 2 increased circulating serum albumin level 0.00454356602543039 0.0456651332858913 1.2512099921936 0.514285714285714 21.2 21 2 decreased triglyceride level 0.00454356602543039 0.0456651332858913 1.2512099921936 0.514285714285714 21.2 21 2 abnormal hippocampus pyramidal cell morphology 0.00454356602543039 0.0456651332858913 1.2512099921936 0.514285714285714 21.2 21 2 abnormal forebrain development 5.91353648742442e-05 0.0014281477682008 1.25024455238481 0.513888888888889 21.2 21 2 abnormal branching of the mammary ductal tree 0.00366688822794415 0.0384058293347835 1.24933129851163 0.513513513513513 21.2 21 2 abnormal vocalization 0.00366688822794415 0.0384058293347835 1.24933129851163 0.513513513513513 21.2 21 2 increased circulating phosphate level 0.00366688822794415 0.0384058293347835 1.24933129851163 0.513513513513513 21.2 21 2 increased bone trabecula number 0.00239515225372388 0.0287257791930934 1.24612377271314 0.51219512195122 21.2 21 2 lethality at weaning, incomplete penetrance 0.00239515225372388 0.0287257791930934 1.24612377271314 0.51219512195122 21.2 21 2 abnormal homeostasis 0.00193819074123121 0.0244434391432123 1.24474379068355 0.511627906976744 21.2 21 2 abnormal cell migration 0.00156958014629676 0.0203881494199122 1.24348647372327 0.511111111111111 21.2 21 2 small placenta 0.00156958014629676 0.0203881494199122 1.24348647372327 0.511111111111111 21.2 21 2 increased circulating LDL cholesterol level 0.0010314028438145 0.0147651622614863 1.24127975416032 0.510204081632653 21.2 21 2 impaired balance 2.84204334590938e-06 0.000111332012959836 1.24030620141196 0.509803921568627 21.2 21 2 abnormal gastrulation 0.00083684115585681 0.0122810759598455 1.24030620141196 0.509803921568627 21.2 21 2 abnormal gluconeogenesis 0.00083684115585681 0.0122810759598455 1.24030620141196 0.509803921568627 21.2 21 2 abnormal response to novel object 0.00083684115585681 0.0122810759598455 1.24030620141196 0.509803921568627 21.2 21 2 abnormal placenta development 0.000679351091295062 0.0104313940715831 1.23940612434272 0.509433962264151 21.2 21 2 abnormal head morphology 0.000551779663460935 0.00865963351961561 1.23857150742397 0.509090909090909 21.2 21 2 embryonic lethality during organogenesis, incomplete penetrance 3.22581702012347e-12 4.33741612840926e-10 1.2376098835828 0.508695652173913 21.2 21 2 abnormal maternal nurturing 0.000296455766219013 0.00530527855014241 1.23639603053739 0.508196721311475 21.2 21 2 abnormal bone structure 2.02478999205645e-10 2.01466604209616e-08 1.23536277294877 0.507772020725389 21.2 21 2 decreased white adipose tissue amount 0.00015983741304901 0.00327239148114743 1.23461019130214 0.507462686567164 21.2 21 2 decreased liver weight 0.00010605796521336 0.00232439813628398 1.23358731624721 0.507042253521127 21.2 21 2 decreased percent body fat/body weight 8.64306456812235e-05 0.00196343590074926 1.23311791468091 0.506849315068493 21.2 21 2 hyperactivity 1.70939809886614e-18 5.31515971366191e-16 1.23284841998111 0.506738544474393 21.2 21 2 decreased total body fat amount 1.07342480084578e-16 2.67014419210387e-14 1.23102247235947 0.505988023952096 21.2 21 2 abnormal muscle physiology 1.69617296301867e-05 0.000505297035390292 1.2301221833364 0.50561797752809 21.2 21 2 decreased body weight 3.25535002223754e-58 1.61953663606317e-54 1.2282453140924 0.504846526655897 21.2 21 2 increased insulin sensitivity 7.45966247522896e-08 4.47130371256194e-06 1.22496083151821 0.503496503496504 21.2 21 2 polydactyly 1.08477275232705e-05 0.000350437950832926 1.21645415907711 0.5 21.2 21 2 domed cranium 0.000187851588514777 0.00363642666482886 1.21645415907711 0.5 21.2 21 2 intracranial hemorrhage 0.000527268650638238 0.00832749694261979 1.21645415907711 0.5 21.2 21 2 abnormal axon extension 0.00149683946937093 0.0195967798950537 1.21645415907711 0.5 21.2 21 2 muscular atrophy 0.00282014885961959 0.0326284664572267 1.21645415907711 0.5 21.2 21 2 omphalocele 0.00282014885961959 0.0326284664572267 1.21645415907711 0.5 21.2 21 2 decreased blood urea nitrogen level 0.00282014885961959 0.0326284664572267 1.21645415907711 0.5 21.2 21 2 abnormal pancreas morphology 0.00348856821179428 0.0377597321442046 1.21645415907711 0.5 21.2 21 2 abnormal auditory brainstem response waveform shape 0.0102623301871428 0.0810398296524369 1.21645415907711 0.5 21.2 21 2 abnormal heart tube morphology 0.0127843694069524 0.0971026531291419 1.21645415907711 0.5 21.2 21 2 abnormal response to new environment 0.0127843694069524 0.0971026531291419 1.21645415907711 0.5 21.2 21 2 disorganized myocardium 0.0127843694069524 0.0971026531291419 1.21645415907711 0.5 21.2 21 2 abnormal cellular respiration 0.0127843694069524 0.0971026531291419 1.21645415907711 0.5 21.2 21 2 prolonged QRS complex duration 0.0159534108914225 0.115697112514325 1.21645415907711 0.5 21.2 21 2 thick skin 0.0199467183938413 0.137826283346334 1.21645415907711 0.5 21.2 21 2 increased susceptibility to otitis media 0.0199467183938413 0.137826283346334 1.21645415907711 0.5 21.2 21 2 decreased bone resorption 0.0199467183938413 0.137826283346334 1.21645415907711 0.5 21.2 21 2 abnormal oogenesis 0.0314031166098461 0.177590098471058 1.21645415907711 0.5 21.2 21 2 increased myocardial infarction size 0.0314031166098461 0.177590098471058 1.21645415907711 0.5 21.2 21 2 aphakia 0.0314031166098461 0.177590098471058 1.21645415907711 0.5 21.2 21 2 prolonged PR interval 0.0314031166098461 0.177590098471058 1.21645415907711 0.5 21.2 21 2 abnormal pericardium morphology 0.0395741504376434 0.211246135651584 1.21645415907711 0.5 21.2 21 2 decreased paired-pulse facilitation 0.0395741504376434 0.211246135651584 1.21645415907711 0.5 21.2 21 2 abnormal lens epithelium morphology 0.0395741504376434 0.211246135651584 1.21645415907711 0.5 21.2 21 2 absent placental labyrinth 0.0395741504376434 0.211246135651584 1.21645415907711 0.5 21.2 21 2 abnormal optic stalk morphology 0.0395741504376434 0.211246135651584 1.21645415907711 0.5 21.2 21 2 abnormal response to tactile stimuli 0.0395741504376434 0.211246135651584 1.21645415907711 0.5 21.2 21 2 abnormal mitral valve morphology 0.0500533296039891 0.249435180030188 1.21645415907711 0.5 21.2 21 2 abnormal thymus medulla morphology 0.0500533296039891 0.249435180030188 1.21645415907711 0.5 21.2 21 2 decreased cellular sensitivity to gamma-irradiation 0.0500533296039891 0.249435180030188 1.21645415907711 0.5 21.2 21 2 absent ureter 0.0500533296039891 0.249435180030188 1.21645415907711 0.5 21.2 21 2 long tibia 0.0500533296039891 0.249435180030188 1.21645415907711 0.5 21.2 21 2 abnormal anterior eye segment morphology 0.0500533296039891 0.249435180030188 1.21645415907711 0.5 21.2 21 2 jerky movement 0.0500533296039891 0.249435180030188 1.21645415907711 0.5 21.2 21 2 increased gastrointestinal tumor incidence 0.0500533296039891 0.249435180030188 1.21645415907711 0.5 21.2 21 2 atrioventricular block 0.0500533296039891 0.249435180030188 1.21645415907711 0.5 21.2 21 2 increased effector memory CD4-positive, alpha-beta T cell number 0.0500533296039891 0.249435180030188 1.21645415907711 0.5 21.2 21 2 increased effector memory CD8-positive, alpha-beta T cell number 0.0500533296039891 0.249435180030188 1.21645415907711 0.5 21.2 21 2 paternal imprinting 0.0635886126996815 0.289946103708802 1.21645415907711 0.5 21.2 21 2 increased cochlear outer hair cell number 0.0635886126996815 0.289946103708802 1.21645415907711 0.5 21.2 21 2 impaired somite development 0.0635886126996815 0.289946103708802 1.21645415907711 0.5 21.2 21 2 decreased liver cholesterol level 0.0635886126996815 0.289946103708802 1.21645415907711 0.5 21.2 21 2 abnormal blood flow velocity 0.0812308826021684 0.318061135517257 1.21645415907711 0.5 21.2 21 2 abnormal kidney blood vessel morphology 0.0812308826021684 0.318061135517257 1.21645415907711 0.5 21.2 21 2 abnormal placing response 0.0812308826021684 0.318061135517257 1.21645415907711 0.5 21.2 21 2 increased hemangioma incidence 0.0812308826021684 0.318061135517257 1.21645415907711 0.5 21.2 21 2 abnormal ventral body wall morphology 0.0812308826021684 0.318061135517257 1.21645415907711 0.5 21.2 21 2 abnormal sagittal suture morphology 0.0812308826021684 0.318061135517257 1.21645415907711 0.5 21.2 21 2 abnormal viscerocranium morphology 0.0812308826021684 0.318061135517257 1.21645415907711 0.5 21.2 21 2 increased stomach tumor incidence 0.0812308826021684 0.318061135517257 1.21645415907711 0.5 21.2 21 2 abnormal renal tubule epithelial cell primary cilium morphology 0.0812308826021684 0.318061135517257 1.21645415907711 0.5 21.2 21 2 retarded hair growth 0.135713873075861 0.438141803083976 1.21645415907711 0.5 21.2 21 2 kidney hemorrhage 0.135713873075861 0.438141803083976 1.21645415907711 0.5 21.2 21 2 enlarged testis 0.135713873075861 0.438141803083976 1.21645415907711 0.5 21.2 21 2 abnormal epidermis suprabasal layer morphology 0.135713873075861 0.438141803083976 1.21645415907711 0.5 21.2 21 2 absent trophoblast giant cells 0.135713873075861 0.438141803083976 1.21645415907711 0.5 21.2 21 2 decreased incidence of induced tumors 0.135713873075861 0.438141803083976 1.21645415907711 0.5 21.2 21 2 ketoaciduria 0.135713873075861 0.438141803083976 1.21645415907711 0.5 21.2 21 2 impaired basement membrane formation 0.135713873075861 0.438141803083976 1.21645415907711 0.5 21.2 21 2 intestinal hypoperistalsis 0.135713873075861 0.438141803083976 1.21645415907711 0.5 21.2 21 2 abnormal submandibular gland morphology 0.135713873075861 0.438141803083976 1.21645415907711 0.5 21.2 21 2 abnormal pillar cell morphology 0.135713873075861 0.438141803083976 1.21645415907711 0.5 21.2 21 2 increased susceptibility to atherosclerosis 0.135713873075861 0.438141803083976 1.21645415907711 0.5 21.2 21 2 tachypnea 0.135713873075861 0.438141803083976 1.21645415907711 0.5 21.2 21 2 increased platelet aggregation 0.135713873075861 0.438141803083976 1.21645415907711 0.5 21.2 21 2 absent axillary lymph nodes 0.135713873075861 0.438141803083976 1.21645415907711 0.5 21.2 21 2 abnormal cerebellar granule cell migration 0.135713873075861 0.438141803083976 1.21645415907711 0.5 21.2 21 2 abnormal heart and great artery attachment 0.135713873075861 0.438141803083976 1.21645415907711 0.5 21.2 21 2 abnormal left subclavian artery morphology 0.135713873075861 0.438141803083976 1.21645415907711 0.5 21.2 21 2 decreased trabecular bone connectivity density 0.135713873075861 0.438141803083976 1.21645415907711 0.5 21.2 21 2 abnormal adaptive thermogenesis 0.135713873075861 0.438141803083976 1.21645415907711 0.5 21.2 21 2 decreased macrophage apoptosis 0.135713873075861 0.438141803083976 1.21645415907711 0.5 21.2 21 2 decreased body height 0.0249953339597694 0.153799467871333 1.21645415907711 0.5 21.2 21 2 decreased metastatic potential 0.0249953339597694 0.153799467871333 1.21645415907711 0.5 21.2 21 2 abnormal startle reflex 0.0249953339597694 0.153799467871333 1.21645415907711 0.5 21.2 21 2 abnormal tumor morphology 0.0249953339597694 0.153799467871333 1.21645415907711 0.5 21.2 21 2 increased hemangiosarcoma incidence 0.0249953339597694 0.153799467871333 1.21645415907711 0.5 21.2 21 2 abnormal inner cell mass apoptosis 0.0249953339597694 0.153799467871333 1.21645415907711 0.5 21.2 21 2 abnormal adipose tissue distribution 0.104503621481324 0.36742439354741 1.21645415907711 0.5 21.2 21 2 abnormal supraoccipital bone morphology 0.104503621481324 0.36742439354741 1.21645415907711 0.5 21.2 21 2 impaired embryo implantation 0.104503621481324 0.36742439354741 1.21645415907711 0.5 21.2 21 2 ear inflammation 0.104503621481324 0.36742439354741 1.21645415907711 0.5 21.2 21 2 increased papilloma incidence 0.104503621481324 0.36742439354741 1.21645415907711 0.5 21.2 21 2 altered tumor susceptibility 0.104503621481324 0.36742439354741 1.21645415907711 0.5 21.2 21 2 abnormal tracheal ciliated epithelium morphology 0.104503621481324 0.36742439354741 1.21645415907711 0.5 21.2 21 2 increased growth rate 0.104503621481324 0.36742439354741 1.21645415907711 0.5 21.2 21 2 decreased synaptic depression 0.104503621481324 0.36742439354741 1.21645415907711 0.5 21.2 21 2 increased fear-related response 0.104503621481324 0.36742439354741 1.21645415907711 0.5 21.2 21 2 abnormal defecation 0.104503621481324 0.36742439354741 1.21645415907711 0.5 21.2 21 2 vestibular saccular macula degeneration 0.104503621481324 0.36742439354741 1.21645415907711 0.5 21.2 21 2 stria vascularis degeneration 0.104503621481324 0.36742439354741 1.21645415907711 0.5 21.2 21 2 abnormal palatine bone morphology 0.104503621481324 0.36742439354741 1.21645415907711 0.5 21.2 21 2 abnormal fatty acid level 0.104503621481324 0.36742439354741 1.21645415907711 0.5 21.2 21 2 abnormal somatic nervous system physiology 0.104503621481324 0.36742439354741 1.21645415907711 0.5 21.2 21 2 impaired behavioral response to cocaine 0.104503621481324 0.36742439354741 1.21645415907711 0.5 21.2 21 2 abnormal aorta elastic tissue morphology 0.104503621481324 0.36742439354741 1.21645415907711 0.5 21.2 21 2 decreased mammary gland epithelial cell proliferation 0.104503621481324 0.36742439354741 1.21645415907711 0.5 21.2 21 2 increased fibrosarcoma incidence 0.104503621481324 0.36742439354741 1.21645415907711 0.5 21.2 21 2 increased skeletal muscle glycogen level 0.104503621481324 0.36742439354741 1.21645415907711 0.5 21.2 21 2 abnormal vitelline vein connection 0.104503621481324 0.36742439354741 1.21645415907711 0.5 21.2 21 2 anemia 2.12447326178033e-10 2.07240283869747e-08 1.21068897348907 0.497630331753554 21.2 21 2 prenatal lethality, incomplete penetrance 3.26188380548635e-14 5.59581790768778e-12 1.20845117118844 0.496710526315789 21.2 21 2 decreased anxiety-related response 1.37565202906482e-06 5.84946055093801e-05 1.2065642878651 0.495934959349593 21.2 21 2 abnormal testis morphology 3.07354264487967e-06 0.000116724234032644 1.20587629682427 0.495652173913044 21.2 21 2 hydroencephaly 3.07354264487967e-06 0.000116724234032644 1.20587629682427 0.495652173913044 21.2 21 2 abnormal craniofacial morphology 1.03010557084832e-05 0.00033715626414279 1.20464392452296 0.495145631067961 21.2 21 2 small spleen 3.47104182904006e-05 0.000918533675503953 1.20308653095538 0.494505494505495 21.2 21 2 decreased heart weight 9.6032691743706e-05 0.00214243336961855 1.20143620649591 0.493827160493827 21.2 21 2 abnormal somite development 0.000117792161294171 0.00254789566277609 1.20105600516474 0.493670886075949 21.2 21 2 abnormal ovary morphology 0.000267373166724488 0.00490153853535834 1.19932100190701 0.492957746478873 21.2 21 2 atelectasis 0.000267373166724488 0.00490153853535834 1.19932100190701 0.492957746478873 21.2 21 2 thymus hypoplasia 4.77569642470766e-07 2.32932252087457e-05 1.1988243886557 0.492753623188406 21.2 21 2 decreased spleen weight 0.000328440607769761 0.00575349304103719 1.1988243886557 0.492753623188406 21.2 21 2 seizures 5.30166402016454e-06 0.000181901920691852 1.19511285804067 0.491228070175439 21.2 21 2 absent vitelline blood vessels 0.00113773199235936 0.0157228240610773 1.19511285804067 0.491228070175439 21.2 21 2 abnormal craniofacial bone morphology 0.00113773199235936 0.0157228240610773 1.19511285804067 0.491228070175439 21.2 21 2 abnormal rostral-caudal axis patterning 0.00140175712093175 0.0185471853102007 1.19433681073025 0.490909090909091 21.2 21 2 kinked tail 1.77679342621007e-05 0.00051997337031736 1.19260211674226 0.490196078431373 21.2 21 2 abnormal cued conditioning behavior 0.00213145323236526 0.0258792998126489 1.19260211674226 0.490196078431373 21.2 21 2 respiratory failure 2.0210783691608e-07 1.12976009961517e-05 1.19228619565174 0.490066225165563 21.2 21 2 abnormal embryonic tissue morphology 3.01260430969838e-07 1.57765330955257e-05 1.1916285639939 0.489795918367347 21.2 21 2 abnormal craniofacial development 0.00263078057669378 0.0310145340498852 1.1916285639939 0.489795918367347 21.2 21 2 abnormal spermatogenesis 1.16853016138681e-08 8.30491078985628e-07 1.190009503445 0.489130434782609 21.2 21 2 cardiomyopathy 0.00401634502018926 0.0413691852493614 1.18942184443095 0.488888888888889 21.2 21 2 lethality at weaning, complete penetrance 0.00401634502018926 0.0413691852493614 1.18942184443095 0.488888888888889 21.2 21 2 hypoactivity 5.02099750078072e-16 1.13543011665382e-13 1.18741413936439 0.488063660477454 21.2 21 2 abnormal mammary gland development 0.00615181549721397 0.0581849469555884 1.18678454544108 0.48780487804878 21.2 21 2 premature death 1.95889669468316e-34 1.62425184267479e-31 1.18395886795194 0.48664343786295 21.2 21 2 decreased circulating chloride level 0.00945984372937109 0.0771487554212405 1.18357701964259 0.486486486486487 21.2 21 2 abnormal chromosome morphology 0.00945984372937109 0.0771487554212405 1.18357701964259 0.486486486486487 21.2 21 2 abnormal hair follicle development 0.00945984372937109 0.0771487554212405 1.18357701964259 0.486486486486487 21.2 21 2 ovary cysts 0.0117510611480886 0.0904977232379891 1.18169832596062 0.485714285714286 21.2 21 2 increased red blood cell distribution width 0.0117510611480886 0.0904977232379891 1.18169832596062 0.485714285714286 21.2 21 2 abnormal CNS synaptic transmission 3.71483227093113e-05 0.000977846060734516 1.17959191183235 0.484848484848485 21.2 21 2 abnormal tooth development 0.0146166097577423 0.107889664013009 1.17959191183235 0.484848484848485 21.2 21 2 belly spot 0.0146166097577423 0.107889664013009 1.17959191183235 0.484848484848485 21.2 21 2 abnormal epidermis stratum basale morphology 0.0146166097577423 0.107889664013009 1.17959191183235 0.484848484848485 21.2 21 2 abnormal skeleton physiology 0.0146166097577423 0.107889664013009 1.17959191183235 0.484848484848485 21.2 21 2 increased osteoblast cell number 0.0146166097577423 0.107889664013009 1.17959191183235 0.484848484848485 21.2 21 2 abnormal myocardial fiber morphology 4.54645329634584e-05 0.00115992846919593 1.17883186549741 0.484536082474227 21.2 21 2 decreased circulating glucose level 8.12639409118423e-12 1.03663616932414e-09 1.17721370233269 0.483870967741935 21.2 21 2 hypoglycemia 6.81313166807982e-05 0.00162178612673192 1.17721370233269 0.483870967741935 21.2 21 2 abnormal capillary morphology 0.0182079416144854 0.127315119307381 1.17721370233269 0.483870967741935 21.2 21 2 preaxial polydactyly 0.0182079416144854 0.127315119307381 1.17721370233269 0.483870967741935 21.2 21 2 abnormal eating behavior 0.0012949648346699 0.0174558977651648 1.17590568710787 0.483333333333333 21.2 21 2 abnormal spinal nerve morphology 0.0227195974249027 0.150706662918521 1.17450746393652 0.482758620689655 21.2 21 2 reduced long term potentiation 1.5372923955991e-05 0.000466343272445459 1.1730093676815 0.482142857142857 21.2 21 2 postnatal growth retardation 9.17689439564182e-24 5.07278329092423e-21 1.17272541479656 0.48202614379085 21.2 21 2 abnormal eye morphology 1.57638649719588e-06 6.59035531390712e-05 1.17269681522542 0.482014388489209 21.2 21 2 abnormal visceral yolk sac morphology 0.000282323097709213 0.005088976127186 1.17025969734 0.481012658227848 21.2 21 2 decreased bone mineral content 5.91754887666104e-09 4.26663850165053e-07 1.16966746065107 0.480769230769231 21.2 21 2 eyelids open at birth 0.00298134360800115 0.0340510340325771 1.16966746065107 0.480769230769231 21.2 21 2 reduced male fertility 1.37485212553419e-09 1.15930327534451e-07 1.16822469902559 0.480176211453745 21.2 21 2 decreased double-positive T cell number 5.1365544851772e-05 0.00127771792818783 1.16779599271403 0.48 21.2 21 2 abnormal interventricular septum morphology 0.00367749544499179 0.0384360080647776 1.16779599271403 0.48 21.2 21 2 abnormal nest building behavior 0.0355849389801254 0.193058965568292 1.16779599271403 0.48 21.2 21 2 increased pre-B cell number 0.0355849389801254 0.193058965568292 1.16779599271403 0.48 21.2 21 2 delayed bone ossification 0.00042463065960209 0.00707745531649108 1.16779599271403 0.48 21.2 21 2 abnormal neurocranium morphology 0.00042463065960209 0.00707745531649108 1.16779599271403 0.48 21.2 21 2 spleen hyperplasia 0.00042463065960209 0.00707745531649108 1.16779599271403 0.48 21.2 21 2 abnormal fertility/fecundity 0.000520971044017853 0.00825423867512363 1.16646289226572 0.479452054794521 21.2 21 2 cyanosis 2.87345399594175e-08 1.90605781730803e-06 1.16576856911556 0.479166666666667 21.2 21 2 abnormal gait 2.23508620168922e-12 3.08876495927886e-10 1.16527647600914 0.478964401294498 21.2 21 2 perinatal lethality, complete penetrance 5.46749357804253e-09 4.0001147868767e-07 1.16505468756681 0.47887323943662 21.2 21 2 reduced female fertility 1.26948276319271e-09 1.08890978394547e-07 1.16402079015137 0.478448275862069 21.2 21 2 perimembraneous ventricular septal defect 0.00078485412519916 0.011690566685227 1.16356484781289 0.478260869565217 21.2 21 2 fragile skeleton 0.0446946169286973 0.229232700227081 1.16356484781289 0.478260869565217 21.2 21 2 abnormal innervation pattern to muscle 0.0446946169286973 0.229232700227081 1.16356484781289 0.478260869565217 21.2 21 2 abnormal circulating insulin level 0.0446946169286973 0.229232700227081 1.16356484781289 0.478260869565217 21.2 21 2 abnormal sacral vertebrae morphology 0.0446946169286973 0.229232700227081 1.16356484781289 0.478260869565217 21.2 21 2 abnormal chondrocyte physiology 0.0446946169286973 0.229232700227081 1.16356484781289 0.478260869565217 21.2 21 2 limb grasping 7.71527046649194e-08 4.56946078223779e-06 1.1629836465902 0.478021978021978 21.2 21 2 internal hemorrhage 0.000963775903311708 0.0138577604594675 1.16198606240202 0.477611940298507 21.2 21 2 insulin resistance 4.80160078236916e-06 0.000165888638140879 1.16116078820997 0.477272727272727 21.2 21 2 embryonic lethality, incomplete penetrance 0.00692998821872116 0.0633111780938412 1.16116078820997 0.477272727272727 21.2 21 2 infertility 3.85629873863009e-05 0.00100974138024656 1.15961050678379 0.476635514018692 21.2 21 2 decreased body size 6.13076514758435e-29 3.81256957615402e-26 1.15852777054963 0.476190476190476 21.2 21 2 abnormal nervous system electrophysiology 0.000258530048588543 0.00478136428151674 1.15852777054963 0.476190476190476 21.2 21 2 decreased susceptibility to hepatic steatosis 0.0014547502312961 0.0191973007976076 1.15852777054963 0.476190476190476 21.2 21 2 skin edema 0.00857294939305003 0.0730315466274381 1.15852777054963 0.476190476190476 21.2 21 2 increased incidence of induced tumors 0.0563004448003034 0.267776972162055 1.15852777054963 0.476190476190476 21.2 21 2 abnormal erythrocyte physiology 0.0563004448003034 0.267776972162055 1.15852777054963 0.476190476190476 21.2 21 2 abnormal tumor vascularization 0.0563004448003034 0.267776972162055 1.15852777054963 0.476190476190476 21.2 21 2 complete atrioventricular septal defect 0.0563004448003034 0.267776972162055 1.15852777054963 0.476190476190476 21.2 21 2 neonatal lethality, complete penetrance 4.65974181139738e-17 1.36365973598247e-14 1.1577655812269 0.475877192982456 21.2 21 2 abnormal excitatory postsynaptic potential 0.000316640513736756 0.005586122538441 1.15711493180506 0.475609756097561 21.2 21 2 postnatal lethality, incomplete penetrance 8.57392977526882e-21 3.28117697168941e-18 1.15648810898176 0.475352112676056 21.2 21 2 decreased circulating phosphate level 0.0106148521615581 0.0834263657247263 1.15563145112325 0.475 21.2 21 2 small testis 8.58475055842895e-11 8.89773625587167e-09 1.15474996260218 0.47463768115942 21.2 21 2 decreased leukocyte cell number 4.39976516895252e-06 0.000158614722576368 1.15429956700748 0.474452554744526 21.2 21 2 increased rib number 0.000475261061703145 0.00772687510448741 1.15407189450905 0.474358974358974 21.2 21 2 absent gastric milk in neonates 0.000475261061703145 0.00772687510448741 1.15407189450905 0.474358974358974 21.2 21 2 respiratory distress 2.81887095279434e-07 1.50794440754321e-05 1.15317041669738 0.473988439306358 21.2 21 2 abnormal facial morphology 0.00270545755518712 0.0315954256738402 1.15243025596779 0.473684210526316 21.2 21 2 increased grooming behavior 0.0131558850729453 0.0996202865112677 1.15243025596779 0.473684210526316 21.2 21 2 abnormal compact bone morphology 0.0131558850729453 0.0996202865112677 1.15243025596779 0.473684210526316 21.2 21 2 flaky skin 0.0711652125504149 0.313315869414437 1.15243025596779 0.473684210526316 21.2 21 2 stereotypic behavior 0.0711652125504149 0.313315869414437 1.15243025596779 0.473684210526316 21.2 21 2 increased liver adenoma incidence 0.0711652125504149 0.313315869414437 1.15243025596779 0.473684210526316 21.2 21 2 oliguria 0.0711652125504149 0.313315869414437 1.15243025596779 0.473684210526316 21.2 21 2 abnormal sternebra morphology 0.0711652125504149 0.313315869414437 1.15243025596779 0.473684210526316 21.2 21 2 decreased liver regeneration 0.0711652125504149 0.313315869414437 1.15243025596779 0.473684210526316 21.2 21 2 abnormal behavioral response to xenobiotic 0.0711652125504149 0.313315869414437 1.15243025596779 0.473684210526316 21.2 21 2 abnormal angiogenesis 0.000713945978480647 0.0106663100388625 1.15069988020808 0.472972972972973 21.2 21 2 increased granulocyte number 0.000713945978480647 0.0106663100388625 1.15069988020808 0.472972972972973 21.2 21 2 small seminiferous tubules 0.000713945978480647 0.0106663100388625 1.15069988020808 0.472972972972973 21.2 21 2 abnormal learning/memory/conditioning 0.00332989011158338 0.0363293932129985 1.15010211403654 0.472727272727273 21.2 21 2 abnormal seminiferous tubule morphology 2.70442998124924e-06 0.00010763631325372 1.14979913666193 0.472602739726027 21.2 21 2 short snout 5.2512897344877e-05 0.00129975952383464 1.14887337246171 0.472222222222222 21.2 21 2 enlarged kidney 0.00410039485058517 0.0419742065466281 1.14759826328029 0.471698113207547 21.2 21 2 increased circulating bilirubin level 0.00410039485058517 0.0419742065466281 1.14759826328029 0.471698113207547 21.2 21 2 distended abdomen 0.00505175518954872 0.0494733898976474 1.14489803207257 0.470588235294118 21.2 21 2 impaired hematopoiesis 0.00505175518954872 0.0494733898976474 1.14489803207257 0.470588235294118 21.2 21 2 enlarged liver sinusoidal spaces 0.020275571495471 0.139904255464588 1.14489803207257 0.470588235294118 21.2 21 2 abnormal vagus nerve morphology 0.0903285475265648 0.327778646203253 1.14489803207257 0.470588235294118 21.2 21 2 increased incidence of corneal inflammation 0.0903285475265648 0.327778646203253 1.14489803207257 0.470588235294118 21.2 21 2 abnormal dorsal-ventral axis patterning 0.0903285475265648 0.327778646203253 1.14489803207257 0.470588235294118 21.2 21 2 abnormal touch/ nociception 0.0903285475265648 0.327778646203253 1.14489803207257 0.470588235294118 21.2 21 2 pancytopenia 0.0903285475265648 0.327778646203253 1.14489803207257 0.470588235294118 21.2 21 2 abnormal survival 0.0903285475265648 0.327778646203253 1.14489803207257 0.470588235294118 21.2 21 2 abnormal ductus venosus valve morphology 0.0903285475265648 0.327778646203253 1.14489803207257 0.470588235294118 21.2 21 2 abnormal cell cytoskeleton morphology 0.0903285475265648 0.327778646203253 1.14489803207257 0.470588235294118 21.2 21 2 abnormal cranium morphology 8.85633801278593e-06 0.000297704605497365 1.14383003017698 0.470149253731343 21.2 21 2 abnormal liver physiology 0.0001167982331133 0.00253742886348764 1.14346690953248 0.47 21.2 21 2 abnormal blood vessel morphology 4.44821250700524e-06 0.000158911098316826 1.14095010782405 0.468965517241379 21.2 21 2 decreased caudal vertebrae number 0.00198316812010057 0.0246656534937509 1.14042577413479 0.46875 21.2 21 2 abnormal osteoclast physiology 0.00198316812010057 0.0246656534937509 1.14042577413479 0.46875 21.2 21 2 failure of primitive streak formation 0.0252187752268467 0.153799467871333 1.14042577413479 0.46875 21.2 21 2 abnormal heart atrium morphology 0.0252187752268467 0.153799467871333 1.14042577413479 0.46875 21.2 21 2 pancreatic islet hyperplasia 0.0252187752268467 0.153799467871333 1.14042577413479 0.46875 21.2 21 2 reduced fertility 8.03260758278301e-06 0.000271851855267656 1.13769094014406 0.467625899280576 21.2 21 2 oxidative stress 0.000317805337645952 0.0055868606176276 1.13535721513864 0.466666666666667 21.2 21 2 epidermal hyperplasia 0.00299022005833775 0.0340510340325771 1.13535721513864 0.466666666666667 21.2 21 2 abnormal ectoderm development 0.00947942601743655 0.0771487554212405 1.13535721513864 0.466666666666667 21.2 21 2 abnormal microglial cell physiology 0.0314129219406092 0.177590098471058 1.13535721513864 0.466666666666667 21.2 21 2 macrocytosis 0.115235950617337 0.386841332200575 1.13535721513864 0.466666666666667 21.2 21 2 abnormal enteric neuron morphology 0.115235950617337 0.386841332200575 1.13535721513864 0.466666666666667 21.2 21 2 abnormal epidermis stratum spinosum morphology 0.115235950617337 0.386841332200575 1.13535721513864 0.466666666666667 21.2 21 2 no suckling reflex 0.115235950617337 0.386841332200575 1.13535721513864 0.466666666666667 21.2 21 2 decreased aggression towards males 0.115235950617337 0.386841332200575 1.13535721513864 0.466666666666667 21.2 21 2 abnormal ear development 0.115235950617337 0.386841332200575 1.13535721513864 0.466666666666667 21.2 21 2 abnormal neurotransmitter secretion 0.115235950617337 0.386841332200575 1.13535721513864 0.466666666666667 21.2 21 2 decreased thymocyte apoptosis 0.115235950617337 0.386841332200575 1.13535721513864 0.466666666666667 21.2 21 2 ostium primum atrial septal defect 0.115235950617337 0.386841332200575 1.13535721513864 0.466666666666667 21.2 21 2 bicuspid aortic valve 0.115235950617337 0.386841332200575 1.13535721513864 0.466666666666667 21.2 21 2 increased circulating cholesterol level 6.88806080080899e-07 3.20262640037614e-05 1.1335141027764 0.465909090909091 21.2 21 2 abnormal organ of Corti morphology 0.0117072758399197 0.0904405237633551 1.13158526425778 0.465116279069767 21.2 21 2 abnormal axon guidance 0.0117072758399197 0.0904405237633551 1.13158526425778 0.465116279069767 21.2 21 2 delayed endochondral bone ossification 0.0117072758399197 0.0904405237633551 1.13158526425778 0.465116279069767 21.2 21 2 arrest of spermatogenesis 0.000580031082181984 0.00907438564105463 1.12956457628589 0.464285714285714 21.2 21 2 abnormal jaw morphology 0.0391925089498728 0.210564505427233 1.12956457628589 0.464285714285714 21.2 21 2 abnormal hormone level 0.0391925089498728 0.210564505427233 1.12956457628589 0.464285714285714 21.2 21 2 increased bone resorption 0.0391925089498728 0.210564505427233 1.12956457628589 0.464285714285714 21.2 21 2 scaly skin 0.0144692929171282 0.107600496655774 1.12744531816903 0.463414634146341 21.2 21 2 decreased tumor growth/size 0.00555038259983347 0.0536177736585854 1.12634644358992 0.462962962962963 21.2 21 2 cataract 4.72733742309942e-05 0.00118780321615756 1.12597409765815 0.462809917355372 21.2 21 2 lethargy 0.000348540891663791 0.00604287090028317 1.12489309334012 0.462365591397849 21.2 21 2 abnormal motor capabilities/coordination/movement 2.35628586587541e-05 0.000658568661951132 1.12429854096521 0.462121212121212 21.2 21 2 thrombocytopenia 9.68015685664137e-06 0.00031893232027676 1.12417142976781 0.462068965517241 21.2 21 2 abnormal locomotor activation 0.000425358621031323 0.00707745531649108 1.12288076222502 0.461538461538462 21.2 21 2 abnormal snout morphology 0.006826393688018 0.0625438464049531 1.12288076222502 0.461538461538462 21.2 21 2 abnormal heart looping 0.0178971036628714 0.125760015145177 1.12288076222502 0.461538461538462 21.2 21 2 small lens 0.0178971036628714 0.125760015145177 1.12288076222502 0.461538461538462 21.2 21 2 decreased circulating glycerol level 0.0489891280540832 0.247683853728724 1.12288076222502 0.461538461538462 21.2 21 2 absent myocardial trabeculae 0.147950309576326 0.469482447580993 1.12288076222502 0.461538461538462 21.2 21 2 absent trabeculae carneae 0.147950309576326 0.469482447580993 1.12288076222502 0.461538461538462 21.2 21 2 abnormal sympathetic ganglion morphology 0.147950309576326 0.469482447580993 1.12288076222502 0.461538461538462 21.2 21 2 excessive scratching 0.147950309576326 0.469482447580993 1.12288076222502 0.461538461538462 21.2 21 2 abnormal telomere length 0.147950309576326 0.469482447580993 1.12288076222502 0.461538461538462 21.2 21 2 abnormal dopaminergic neuron morphology 0.147950309576326 0.469482447580993 1.12288076222502 0.461538461538462 21.2 21 2 abnormal afterhyperpolarization 0.147950309576326 0.469482447580993 1.12288076222502 0.461538461538462 21.2 21 2 increased cochlear inner hair cell number 0.147950309576326 0.469482447580993 1.12288076222502 0.461538461538462 21.2 21 2 increased circulating ammonia level 0.147950309576326 0.469482447580993 1.12288076222502 0.461538461538462 21.2 21 2 small pituitary gland 0.147950309576326 0.469482447580993 1.12288076222502 0.461538461538462 21.2 21 2 increased prostaglandin level 0.147950309576326 0.469482447580993 1.12288076222502 0.461538461538462 21.2 21 2 increased circulating chloride level 0.00839923949480621 0.0717976228293143 1.11913782635094 0.46 21.2 21 2 decreased oocyte number 0.00839923949480621 0.0717976228293143 1.11913782635094 0.46 21.2 21 2 decreased respiratory quotient 0.00839923949480621 0.0717976228293143 1.11913782635094 0.46 21.2 21 2 decreased width of hypertrophic chondrocyte zone 0.0221560173745511 0.147361211816032 1.11782274077356 0.459459459459459 21.2 21 2 increased trabecular bone volume 0.0221560173745511 0.147361211816032 1.11782274077356 0.459459459459459 21.2 21 2 abnormal respiratory electron transport chain 0.0221560173745511 0.147361211816032 1.11782274077356 0.459459459459459 21.2 21 2 ocular hypertelorism 0.0613632409793284 0.288546430881057 1.11508297915402 0.458333333333333 21.2 21 2 abnormal nursing 0.0613632409793284 0.288546430881057 1.11508297915402 0.458333333333333 21.2 21 2 increased stereotypic behavior 0.0613632409793284 0.288546430881057 1.11508297915402 0.458333333333333 21.2 21 2 blindness 0.0613632409793284 0.288546430881057 1.11508297915402 0.458333333333333 21.2 21 2 prolonged QT interval 0.0613632409793284 0.288546430881057 1.11508297915402 0.458333333333333 21.2 21 2 decreased ovulation rate 0.0613632409793284 0.288546430881057 1.11508297915402 0.458333333333333 21.2 21 2 increased body temperature 0.0613632409793284 0.288546430881057 1.11508297915402 0.458333333333333 21.2 21 2 increased T cell proliferation 0.000187436300574929 0.00363642666482886 1.11413558494913 0.457943925233645 21.2 21 2 increased hemoglobin content 0.0049176446850373 0.048446103580318 1.1133648235621 0.457627118644068 21.2 21 2 increased circulating HDL cholesterol level 0.000228171603800465 0.00426749522145607 1.11218665972764 0.457142857142857 21.2 21 2 abnormal liver development 0.0274541065248455 0.159305763271438 1.11218665972764 0.457142857142857 21.2 21 2 thick pulmonary interalveolar septum 0.0274541065248455 0.159305763271438 1.11218665972764 0.457142857142857 21.2 21 2 abnormal dermal layer morphology 0.0274541065248455 0.159305763271438 1.11218665972764 0.457142857142857 21.2 21 2 abnormal midbrain development 0.0274541065248455 0.159305763271438 1.11218665972764 0.457142857142857 21.2 21 2 decreased bone volume 0.0274541065248455 0.159305763271438 1.11218665972764 0.457142857142857 21.2 21 2 increased or absent threshold for auditory brainstem response 1.68707811217322e-09 1.39886893467696e-07 1.11122456054103 0.456747404844291 21.2 21 2 abnormal circulating amino acid level 0.00603205117359784 0.0571608658831414 1.10974765389491 0.456140350877193 21.2 21 2 abnormal glucose homeostasis 1.74787602926839e-06 7.24640270467518e-05 1.1095131341033 0.456043956043956 21.2 21 2 decreased insulin secretion 0.000687580542407734 0.0104929852714064 1.10832490049248 0.455555555555556 21.2 21 2 abnormal platelet physiology 0.00740079300670854 0.0651662747050885 1.10586741734283 0.454545454545455 21.2 21 2 abnormal astrocyte morphology 0.0156883488575852 0.114274576232045 1.10586741734283 0.454545454545455 21.2 21 2 abnormal amino acid level 0.0156883488575852 0.114274576232045 1.10586741734283 0.454545454545455 21.2 21 2 decreased brown adipose tissue amount 0.0340539131177669 0.186173865671308 1.10586741734283 0.454545454545455 21.2 21 2 cardiovascular system phenotype 0.0340539131177669 0.186173865671308 1.10586741734283 0.454545454545455 21.2 21 2 abnormal chorion morphology 0.0770482182923512 0.317918983497174 1.10586741734283 0.454545454545455 21.2 21 2 abnormal channel response 0.0770482182923512 0.317918983497174 1.10586741734283 0.454545454545455 21.2 21 2 decreased circulating estradiol level 0.0770482182923512 0.317918983497174 1.10586741734283 0.454545454545455 21.2 21 2 abnormal occipital bone morphology 0.0770482182923512 0.317918983497174 1.10586741734283 0.454545454545455 21.2 21 2 increased circulating creatine kinase level 0.0770482182923512 0.317918983497174 1.10586741734283 0.454545454545455 21.2 21 2 increased mammary gland tumor incidence 0.0770482182923512 0.317918983497174 1.10586741734283 0.454545454545455 21.2 21 2 decreased atrioventricular cushion size 0.191520163335666 0.543093901411143 1.10586741734283 0.454545454545455 21.2 21 2 abnormal stomach epithelium morphology 0.191520163335666 0.543093901411143 1.10586741734283 0.454545454545455 21.2 21 2 social withdrawal 0.191520163335666 0.543093901411143 1.10586741734283 0.454545454545455 21.2 21 2 abnormal hypothalamus secretion 0.191520163335666 0.543093901411143 1.10586741734283 0.454545454545455 21.2 21 2 allodynia 0.191520163335666 0.543093901411143 1.10586741734283 0.454545454545455 21.2 21 2 fused joints 0.191520163335666 0.543093901411143 1.10586741734283 0.454545454545455 21.2 21 2 loss of cortex neurons 0.191520163335666 0.543093901411143 1.10586741734283 0.454545454545455 21.2 21 2 abnormal nerve fiber response 0.191520163335666 0.543093901411143 1.10586741734283 0.454545454545455 21.2 21 2 abnormal pituitary gland development 0.191520163335666 0.543093901411143 1.10586741734283 0.454545454545455 21.2 21 2 abnormal coronal suture morphology 0.191520163335666 0.543093901411143 1.10586741734283 0.454545454545455 21.2 21 2 increased motor neuron number 0.191520163335666 0.543093901411143 1.10586741734283 0.454545454545455 21.2 21 2 abnormal Bruch membrane morphology 0.191520163335666 0.543093901411143 1.10586741734283 0.454545454545455 21.2 21 2 abnormal palate development 0.191520163335666 0.543093901411143 1.10586741734283 0.454545454545455 21.2 21 2 abnormal palatal shelf elevation 0.191520163335666 0.543093901411143 1.10586741734283 0.454545454545455 21.2 21 2 decreased palatine bone horizontal plate size 0.191520163335666 0.543093901411143 1.10586741734283 0.454545454545455 21.2 21 2 aorta dilation 0.191520163335666 0.543093901411143 1.10586741734283 0.454545454545455 21.2 21 2 abnormal phrenic nerve innervation pattern to diaphragm 0.191520163335666 0.543093901411143 1.10586741734283 0.454545454545455 21.2 21 2 improved glucose tolerance 9.48920245360491e-07 4.21506983988254e-05 1.10473898120268 0.454081632653061 21.2 21 2 decreased hemoglobin content 3.01983646737961e-05 0.000820966471323147 1.10429881107709 0.453900709219858 21.2 21 2 decreased circulating LDL cholesterol level 0.00433755018549833 0.0442199019935536 1.10241158166363 0.453125 21.2 21 2 abnormal nose morphology 0.0422876116209466 0.218652012391346 1.09873278884384 0.451612903225806 21.2 21 2 microphthalmia 1.96787848490419e-05 0.000565907252161753 1.09719394740288 0.450980392156863 21.2 21 2 increased kidney weight 0.0111489587455535 0.0866657339986382 1.09719394740288 0.450980392156863 21.2 21 2 corneal opacity 0.00312321797126169 0.0351538674367125 1.09652205888641 0.450704225352113 21.2 21 2 abnormal skeletal muscle fiber morphology 0.00312321797126169 0.0351538674367125 1.09652205888641 0.450704225352113 21.2 21 2 enlarged liver 0.000538977122693908 0.00848547843481706 1.0948087431694 0.45 21.2 21 2 increased erythrocyte cell number 0.00649462847051867 0.0609637295110007 1.0948087431694 0.45 21.2 21 2 small gonad 0.0970124451881373 0.347470781001428 1.0948087431694 0.45 21.2 21 2 anencephaly 0.0970124451881373 0.347470781001428 1.0948087431694 0.45 21.2 21 2 abnormal hearing physiology 0.0970124451881373 0.347470781001428 1.0948087431694 0.45 21.2 21 2 abnormal trachea morphology 0.0970124451881373 0.347470781001428 1.0948087431694 0.45 21.2 21 2 abnormal Peyer's patch T cell area morphology 0.0970124451881373 0.347470781001428 1.0948087431694 0.45 21.2 21 2 spleen atrophy 0.0970124451881373 0.347470781001428 1.0948087431694 0.45 21.2 21 2 abnormal physiological neovascularization 0.0970124451881373 0.347470781001428 1.0948087431694 0.45 21.2 21 2 abnormal postnatal subventricular zone morphology 0.0970124451881373 0.347470781001428 1.0948087431694 0.45 21.2 21 2 abnormal sternum morphology 0.00381278403646585 0.0396832648146812 1.09304576612726 0.449275362318841 21.2 21 2 increased sarcoma incidence 0.0136893646818138 0.102105831022524 1.09232618366108 0.448979591836735 21.2 21 2 abnormal spermiogenesis 0.00794832090488414 0.0690102905790552 1.09061407365534 0.448275862068966 21.2 21 2 abnormal microglial cell morphology 0.052576749563911 0.253950804932483 1.09061407365534 0.448275862068966 21.2 21 2 lordosis 0.052576749563911 0.253950804932483 1.09061407365534 0.448275862068966 21.2 21 2 decreased compact bone thickness 0.0046546040202673 0.046592867204889 1.08936193350189 0.447761194029851 21.2 21 2 decreased bone mineral density 4.3883824128712e-08 2.79742458429543e-06 1.08840635285847 0.447368421052632 21.2 21 2 abnormal frontal bone morphology 0.0294418387615654 0.167973793393105 1.08840635285847 0.447368421052632 21.2 21 2 abnormal retinal outer nuclear layer morphology 0.0294418387615654 0.167973793393105 1.08840635285847 0.447368421052632 21.2 21 2 impaired branching involved in ureteric bud morphogenesis 0.0294418387615654 0.167973793393105 1.08840635285847 0.447368421052632 21.2 21 2 no abnormal phenotype detected 1.55112828803848e-45 2.57228774433047e-42 1.08814804316292 0.447262247838617 21.2 21 2 hepatic necrosis 0.0168131746955804 0.120015983091841 1.08704414215401 0.446808510638298 21.2 21 2 abnormal innervation 0.0168131746955804 0.120015983091841 1.08704414215401 0.446808510638298 21.2 21 2 abnormal eye development 0.00972832156593306 0.0776860349767528 1.08611978489028 0.446428571428571 21.2 21 2 increased heart weight 7.50555794842165e-05 0.00174486685950457 1.08518212752203 0.446043165467626 21.2 21 2 kidney cysts 0.0033425802424991 0.0363880453094815 1.08494560133904 0.445945945945946 21.2 21 2 short tail 0.00197715881584563 0.0246656534937509 1.08454949122538 0.44578313253012 21.2 21 2 abnormal lipid level 0.00197715881584563 0.0246656534937509 1.08454949122538 0.44578313253012 21.2 21 2 enlarged spleen 2.2349051482781e-08 1.50252069090318e-06 1.08129258584632 0.444444444444444 21.2 21 2 abnormal rib morphology 0.000109859768132628 0.00239715941429747 1.08129258584632 0.444444444444444 21.2 21 2 abnormal digit morphology 0.0040720150562594 0.0418559398861374 1.08129258584632 0.444444444444444 21.2 21 2 abnormal hair follicle morphology 0.00693663408714377 0.0633111780938412 1.08129258584632 0.444444444444444 21.2 21 2 irregular heartbeat 0.0206554871297041 0.142131463997618 1.08129258584632 0.444444444444444 21.2 21 2 decreased osteoclast cell number 0.0206554871297041 0.142131463997618 1.08129258584632 0.444444444444444 21.2 21 2 abnormal epidermis stratum granulosum morphology 0.0363592795092554 0.196616756041898 1.08129258584632 0.444444444444444 21.2 21 2 renal hypoplasia 0.0363592795092554 0.196616756041898 1.08129258584632 0.444444444444444 21.2 21 2 abnormal retinal blood vessel morphology 0.0363592795092554 0.196616756041898 1.08129258584632 0.444444444444444 21.2 21 2 abnormal heart valve morphology 0.0654580883305901 0.296318461733108 1.08129258584632 0.444444444444444 21.2 21 2 abnormal palate morphology 0.0654580883305901 0.296318461733108 1.08129258584632 0.444444444444444 21.2 21 2 abnormal megakaryocyte differentiation 0.122548721864625 0.408085603264063 1.08129258584632 0.444444444444444 21.2 21 2 absent spleen 0.122548721864625 0.408085603264063 1.08129258584632 0.444444444444444 21.2 21 2 abnormal phrenic nerve morphology 0.122548721864625 0.408085603264063 1.08129258584632 0.444444444444444 21.2 21 2 thick dermal layer 0.122548721864625 0.408085603264063 1.08129258584632 0.444444444444444 21.2 21 2 abnormal Peyer's patch follicle morphology 0.122548721864625 0.408085603264063 1.08129258584632 0.444444444444444 21.2 21 2 increased circulating glycerol level 0.122548721864625 0.408085603264063 1.08129258584632 0.444444444444444 21.2 21 2 decreased lactate dehydrogenase level 0.122548721864625 0.408085603264063 1.08129258584632 0.444444444444444 21.2 21 2 primary atelectasis 0.122548721864625 0.408085603264063 1.08129258584632 0.444444444444444 21.2 21 2 decreased fluid intake 0.122548721864625 0.408085603264063 1.08129258584632 0.444444444444444 21.2 21 2 male infertility 2.33199720210202e-13 3.74247938079276e-11 1.07860547703457 0.443339960238569 21.2 21 2 decreased B cell proliferation 0.00292421387214433 0.0336758426248102 1.07787077386579 0.443037974683544 21.2 21 2 impaired fertilization 0.00496014467025572 0.0487682208192138 1.07743082661115 0.442857142857143 21.2 21 2 abnormal spleen morphology 1.55318013340759e-05 0.000468307343254713 1.07663184194181 0.442528735632184 21.2 21 2 impaired righting response 0.001250238354131 0.0171348093989029 1.0756015722366 0.442105263157895 21.2 21 2 abnormal heart morphology 8.21143498385266e-07 3.78258231895065e-05 1.07427120541875 0.441558441558442 21.2 21 2 short maxilla 0.0449315512406323 0.22926612043297 1.07334190506804 0.441176470588235 21.2 21 2 thin skin 0.0449315512406323 0.22926612043297 1.07334190506804 0.441176470588235 21.2 21 2 abnormal bone remodeling 0.0449315512406323 0.22926612043297 1.07334190506804 0.441176470588235 21.2 21 2 increased B cell proliferation 0.0103361264114301 0.0814932312153166 1.0721290893561 0.440677966101695 21.2 21 2 decreased exploration in new environment 0.00255393298834366 0.0301800869762701 1.07163818775841 0.44047619047619 21.2 21 2 increased total body fat amount 0.00017054532307943 0.0033536086257714 1.07120590127686 0.440298507462687 21.2 21 2 abnormal hindlimb morphology 0.0178458916144626 0.125760015145177 1.07047965998786 0.44 21.2 21 2 abnormal thyroid gland morphology 0.0816176211215593 0.318061135517257 1.07047965998786 0.44 21.2 21 2 decreased placenta weight 0.0816176211215593 0.318061135517257 1.07047965998786 0.44 21.2 21 2 abnormal vertebrae development 0.0816176211215593 0.318061135517257 1.07047965998786 0.44 21.2 21 2 increased liver glycogen level 0.0816176211215593 0.318061135517257 1.07047965998786 0.44 21.2 21 2 abnormal B cell differentiation 0.0018378728450985 0.0232656931408779 1.06941024973812 0.43956043956044 21.2 21 2 liver fibrosis 0.031200887582404 0.17739933225424 1.06810609089697 0.439024390243902 21.2 21 2 abnormal cholesterol homeostasis 0.031200887582404 0.17739933225424 1.06810609089697 0.439024390243902 21.2 21 2 increased startle reflex 0.00222753775090167 0.0269635044056832 1.06610589222488 0.438202247191011 21.2 21 2 abnormal bone mineralization 0.000414033670886534 0.00700618201585206 1.06565405671218 0.43801652892562 21.2 21 2 decreased lymphocyte cell number 0.000300072169537747 0.00535074925967847 1.06439738919247 0.4375 21.2 21 2 abnormal tooth morphology 0.00895814378842358 0.07477645192518 1.06439738919247 0.4375 21.2 21 2 increased dopamine level 0.0555633732608019 0.265285779244232 1.06439738919247 0.4375 21.2 21 2 neonatal lethality 0.0555633732608019 0.265285779244232 1.06439738919247 0.4375 21.2 21 2 abnormal depression-related behavior 0.0555633732608019 0.265285779244232 1.06439738919247 0.4375 21.2 21 2 abnormal bone marrow cell number 0.155406102331069 0.476368058593388 1.06439738919247 0.4375 21.2 21 2 vasculature congestion 0.155406102331069 0.476368058593388 1.06439738919247 0.4375 21.2 21 2 disorganized retinal layers 0.155406102331069 0.476368058593388 1.06439738919247 0.4375 21.2 21 2 reduced male mating frequency 0.155406102331069 0.476368058593388 1.06439738919247 0.4375 21.2 21 2 poor circulation 0.155406102331069 0.476368058593388 1.06439738919247 0.4375 21.2 21 2 disorganized yolk sac vascular plexus 0.155406102331069 0.476368058593388 1.06439738919247 0.4375 21.2 21 2 abnormal extraembryonic endoderm formation 0.155406102331069 0.476368058593388 1.06439738919247 0.4375 21.2 21 2 increased pancreatic beta cell number 0.155406102331069 0.476368058593388 1.06439738919247 0.4375 21.2 21 2 blepharitis 0.155406102331069 0.476368058593388 1.06439738919247 0.4375 21.2 21 2 loose skin 0.155406102331069 0.476368058593388 1.06439738919247 0.4375 21.2 21 2 decreased creatinine clearance 0.155406102331069 0.476368058593388 1.06439738919247 0.4375 21.2 21 2 abnormal thoracic cage shape 0.155406102331069 0.476368058593388 1.06439738919247 0.4375 21.2 21 2 decreased midbrain size 0.155406102331069 0.476368058593388 1.06439738919247 0.4375 21.2 21 2 oligodactyly 0.0218486269903874 0.145901905070037 1.06439738919247 0.4375 21.2 21 2 abnormal retinal pigmentation 0.00269912400841614 0.0315954256738402 1.06264961022828 0.436781609195402 21.2 21 2 abnormal contextual conditioning behavior 0.0153974520422508 0.112650476338526 1.06163272064911 0.436363636363636 21.2 21 2 cleft secondary palate 0.00194073536915957 0.0244434391432123 1.06116213876939 0.436170212765957 21.2 21 2 increased circulating alanine transaminase level 0.00456286750498712 0.0457666649945784 1.06049849765697 0.435897435897436 21.2 21 2 abnormal response to injury 0.0383627704287379 0.206776579504844 1.06049849765697 0.435897435897436 21.2 21 2 decreased trabecular bone volume 0.0383627704287379 0.206776579504844 1.06049849765697 0.435897435897436 21.2 21 2 impaired glucose tolerance 9.02203112870889e-07 4.04365809597538e-05 1.05949233209942 0.435483870967742 21.2 21 2 enlarged heart 2.03095493730417e-06 8.28196787958054e-05 1.0591540522999 0.435344827586207 21.2 21 2 postnatal lethality, complete penetrance 1.08195921218187e-09 9.61204835822283e-08 1.05888237681324 0.435233160621762 21.2 21 2 abnormal pulmonary artery morphology 0.1019356039567 0.364055728416787 1.05778622528444 0.434782608695652 21.2 21 2 bidirectional circling 0.1019356039567 0.364055728416787 1.05778622528444 0.434782608695652 21.2 21 2 increased susceptibility to age related obesity 0.1019356039567 0.364055728416787 1.05778622528444 0.434782608695652 21.2 21 2 abnormal hepatocyte physiology 0.1019356039567 0.364055728416787 1.05778622528444 0.434782608695652 21.2 21 2 increased circulating triglyceride level 0.000166426198699501 0.00333859007471782 1.05705671754287 0.43448275862069 21.2 21 2 azoospermia 8.77985474588976e-05 0.00198544442549098 1.05579040221787 0.433962264150943 21.2 21 2 emphysema 0.0687608530405534 0.304617314226851 1.05426027120016 0.433333333333333 21.2 21 2 abnormal pain threshold 0.0687608530405534 0.304617314226851 1.05426027120016 0.433333333333333 21.2 21 2 abnormal brain vasculature morphology 0.0687608530405534 0.304617314226851 1.05426027120016 0.433333333333333 21.2 21 2 rib fusion 0.009419552804241 0.0771487554212405 1.05304986905183 0.432835820895522 21.2 21 2 abnormal intestine morphology 0.00670923223350395 0.0616976531639227 1.05206846190453 0.432432432432432 21.2 21 2 increased erythroid progenitor cell number 0.0471808125642684 0.23927068553235 1.05206846190453 0.432432432432432 21.2 21 2 increased exploration in new environment 0.00479346853729759 0.0473164801052689 1.05125668068392 0.432098765432099 21.2 21 2 abnormal circadian rhythm 0.032750768472245 0.182965902489574 1.05057404647569 0.431818181818182 21.2 21 2 cochlear hair cell degeneration 0.032750768472245 0.182965902489574 1.05057404647569 0.431818181818182 21.2 21 2 increased anxiety-related response 0.000289971344105041 0.00520796908636311 1.05017625244067 0.431654676258993 21.2 21 2 alopecia 0.0024650016213109 0.0291985311095755 1.04999201099287 0.431578947368421 21.2 21 2 abnormal cervical vertebrae morphology 0.0229263234460489 0.151673482904379 1.04948986273319 0.431372549019608 21.2 21 2 cochlear inner hair cell degeneration 0.0229263234460489 0.151673482904379 1.04948986273319 0.431372549019608 21.2 21 2 thrombocytosis 0.0161521781925667 0.11679809085468 1.04866737851475 0.431034482758621 21.2 21 2 abnormal neuron differentiation 0.00133603004665009 0.0177397013795182 1.04267499349467 0.428571428571429 21.2 21 2 increased thermal nociceptive threshold 0.00359140877605651 0.0380154439593216 1.04267499349467 0.428571428571429 21.2 21 2 enhanced long term potentiation 0.019649299899489 0.136529702513907 1.04267499349467 0.428571428571429 21.2 21 2 absent kidney 0.0279680737218178 0.16067109326333 1.04267499349467 0.428571428571429 21.2 21 2 abnormal epidermis stratum corneum morphology 0.0279680737218178 0.16067109326333 1.04267499349467 0.428571428571429 21.2 21 2 decreased circulating creatinine level 0.0279680737218178 0.16067109326333 1.04267499349467 0.428571428571429 21.2 21 2 abnormal muscle morphology 0.0400964142240515 0.213575653923615 1.04267499349467 0.428571428571429 21.2 21 2 abnormal intestinal goblet cell morphology 0.0580396347774723 0.274997317159928 1.04267499349467 0.428571428571429 21.2 21 2 holoprosencephaly 0.0580396347774723 0.274997317159928 1.04267499349467 0.428571428571429 21.2 21 2 rib bifurcation 0.085157272866128 0.318061135517257 1.04267499349467 0.428571428571429 21.2 21 2 shortened head 0.085157272866128 0.318061135517257 1.04267499349467 0.428571428571429 21.2 21 2 abnormal ovulation 0.085157272866128 0.318061135517257 1.04267499349467 0.428571428571429 21.2 21 2 abnormal respiration 0.085157272866128 0.318061135517257 1.04267499349467 0.428571428571429 21.2 21 2 increased triglyceride level 0.085157272866128 0.318061135517257 1.04267499349467 0.428571428571429 21.2 21 2 abnormal eye pigmentation 0.127546445479013 0.423311251673174 1.04267499349467 0.428571428571429 21.2 21 2 abnormal hematopoietic system physiology 0.127546445479013 0.423311251673174 1.04267499349467 0.428571428571429 21.2 21 2 decreased cochlear outer hair cell number 0.127546445479013 0.423311251673174 1.04267499349467 0.428571428571429 21.2 21 2 embryonic lethality at implantation, complete penetrance 0.127546445479013 0.423311251673174 1.04267499349467 0.428571428571429 21.2 21 2 irregularly shaped pupil 0.197989879806944 0.543093901411143 1.04267499349467 0.428571428571429 21.2 21 2 extended life span 0.197989879806944 0.543093901411143 1.04267499349467 0.428571428571429 21.2 21 2 decreased coping response 0.197989879806944 0.543093901411143 1.04267499349467 0.428571428571429 21.2 21 2 abnormal voluntary movement 0.197989879806944 0.543093901411143 1.04267499349467 0.428571428571429 21.2 21 2 abnormal decidualization 0.197989879806944 0.543093901411143 1.04267499349467 0.428571428571429 21.2 21 2 skeletal muscle necrosis 0.197989879806944 0.543093901411143 1.04267499349467 0.428571428571429 21.2 21 2 decreased CNS synapse formation 0.197989879806944 0.543093901411143 1.04267499349467 0.428571428571429 21.2 21 2 decreased tongue size 0.197989879806944 0.543093901411143 1.04267499349467 0.428571428571429 21.2 21 2 sternebra fusion 0.197989879806944 0.543093901411143 1.04267499349467 0.428571428571429 21.2 21 2 abnormal vitelline vein topology 0.197989879806944 0.543093901411143 1.04267499349467 0.428571428571429 21.2 21 2 decreased rib number 0.00433227694346149 0.0442199019935536 1.0387698437063 0.426966292134831 21.2 21 2 abnormal enzyme/coenzyme activity 0.000199976006639983 0.00378281609518599 1.03824749883014 0.426751592356688 21.2 21 2 increased osteoclast cell number 0.0168439706233908 0.120015983091841 1.03697731593459 0.426229508196721 21.2 21 2 abnormal NK cell physiology 0.0168439706233908 0.120015983091841 1.03697731593459 0.426229508196721 21.2 21 2 abnormal pulmonary alveolus morphology 0.0026875767141962 0.0315346560215238 1.03579265030328 0.425742574257426 21.2 21 2 increased respiratory quotient 0.0341104792373753 0.186278412959322 1.03528013538477 0.425531914893617 21.2 21 2 liver inflammation 0.00120717641366008 0.0165903388341406 1.03398603521554 0.425 21.2 21 2 abnormal retinal pigment epithelium morphology 0.00730855834883799 0.0644682230238812 1.03398603521554 0.425 21.2 21 2 abnormal pancreatic beta cell morphology 0.0490856763793943 0.247920040596433 1.03398603521554 0.425 21.2 21 2 abnormal tail morphology 0.0144435859080106 0.107570119599331 1.03214292285331 0.424242424242424 21.2 21 2 increased cardiomyocyte apoptosis 0.0714124491556697 0.313571875153978 1.03214292285331 0.424242424242424 21.2 21 2 single kidney 0.0714124491556697 0.313571875153978 1.03214292285331 0.424242424242424 21.2 21 2 abnormal QRS complex 0.0714124491556697 0.313571875153978 1.03214292285331 0.424242424242424 21.2 21 2 abnormal retina morphology 2.78265800137792e-05 0.000763105111810472 1.03108971578917 0.423809523809524 21.2 21 2 cardiac fibrosis 0.00629515758279291 0.0593151685121112 1.03040822886532 0.423529411764706 21.2 21 2 decreased cardiac muscle contractility 0.00279287481193514 0.0325399348697361 1.02930736537294 0.423076923076923 21.2 21 2 decreased kidney weight 0.0290490139745583 0.166496364658326 1.02930736537294 0.423076923076923 21.2 21 2 abnormal xiphoid process morphology 0.105545182704375 0.369259693357431 1.02930736537294 0.423076923076923 21.2 21 2 abnormal stomach morphology 0.105545182704375 0.369259693357431 1.02930736537294 0.423076923076923 21.2 21 2 abnormal kidney cortex morphology 0.105545182704375 0.369259693357431 1.02930736537294 0.423076923076923 21.2 21 2 increased leukemia incidence 0.105545182704375 0.369259693357431 1.02930736537294 0.423076923076923 21.2 21 2 abnormal ocular fundus morphology 0.105545182704375 0.369259693357431 1.02930736537294 0.423076923076923 21.2 21 2 abnormal Mullerian duct morphology 0.105545182704375 0.369259693357431 1.02930736537294 0.423076923076923 21.2 21 2 abnormal kidney morphology 0.000136478655229018 0.0028583924502902 1.02877266024807 0.422857142857143 21.2 21 2 abnormal vertebrae morphology 0.00241248460282981 0.0288512281227844 1.02673195078068 0.422018348623853 21.2 21 2 postnatal lethality 0.000224518095228991 0.0042150095236386 1.02592519440238 0.421686746987952 21.2 21 2 increased inflammatory response 0.00467210917775279 0.0466741830508437 1.02438244974915 0.421052631578947 21.2 21 2 kyphoscoliosis 0.159918546820414 0.485711093059562 1.02438244974915 0.421052631578947 21.2 21 2 thin dermal layer 0.159918546820414 0.485711093059562 1.02438244974915 0.421052631578947 21.2 21 2 short vibrissae 0.159918546820414 0.485711093059562 1.02438244974915 0.421052631578947 21.2 21 2 decreased tumor incidence 0.159918546820414 0.485711093059562 1.02438244974915 0.421052631578947 21.2 21 2 abnormal neural crest cell migration 0.159918546820414 0.485711093059562 1.02438244974915 0.421052631578947 21.2 21 2 abnormal metatarsal bone morphology 0.159918546820414 0.485711093059562 1.02438244974915 0.421052631578947 21.2 21 2 abnormal digestive system development 0.159918546820414 0.485711093059562 1.02438244974915 0.421052631578947 21.2 21 2 increased left ventricle weight 0.159918546820414 0.485711093059562 1.02438244974915 0.421052631578947 21.2 21 2 abnormal cochlear inner hair cell morphology 0.159918546820414 0.485711093059562 1.02438244974915 0.421052631578947 21.2 21 2 absent amnion 0.159918546820414 0.485711093059562 1.02438244974915 0.421052631578947 21.2 21 2 decreased fertilization frequency 0.159918546820414 0.485711093059562 1.02438244974915 0.421052631578947 21.2 21 2 decreased circulating magnesium level 0.159918546820414 0.485711093059562 1.02438244974915 0.421052631578947 21.2 21 2 increased blood urea nitrogen level 0.000588490096692172 0.00917786279323999 1.0234993614304 0.420689655172414 21.2 21 2 hyperkeratosis 0.014959243419575 0.110255164462793 1.02252668444163 0.420289855072464 21.2 21 2 testicular atrophy 0.0352979297305921 0.191920437606225 1.02182149362477 0.42 21.2 21 2 abnormal retinal photoreceptor layer morphology 0.0878804162880477 0.323160739367641 1.020251875355 0.419354838709677 21.2 21 2 increased oxygen consumption 0.00783969862182031 0.0681861899362868 1.018426737832 0.418604651162791 21.2 21 2 increased circulating creatinine level 0.00783969862182031 0.0681861899362868 1.018426737832 0.418604651162791 21.2 21 2 decreased oxygen consumption 0.0506901405364555 0.249435180030188 1.018426737832 0.418604651162791 21.2 21 2 increased sensitivity to xenobiotic induced morbidity/mortality 0.00299101545170577 0.0340510340325771 1.0173980239554 0.418181818181818 21.2 21 2 abnormal joint morphology 0.0300039877027439 0.170984924193758 1.0173980239554 0.418181818181818 21.2 21 2 abnormal uterus morphology 0.0735256028261984 0.317918983497174 1.01371179923093 0.416666666666667 21.2 21 2 impaired wound healing 0.0735256028261984 0.317918983497174 1.01371179923093 0.416666666666667 21.2 21 2 thymus atrophy 0.0428689451280807 0.221008292240624 1.01371179923092 0.416666666666667 21.2 21 2 abnormal foregut morphology 0.130915863226252 0.432474382171715 1.01371179923092 0.416666666666667 21.2 21 2 abnormal vasodilation 0.130915863226252 0.432474382171715 1.01371179923092 0.416666666666667 21.2 21 2 abnormal primitive streak formation 0.130915863226252 0.432474382171715 1.01371179923092 0.416666666666667 21.2 21 2 abnormal retinal ganglion layer morphology 0.130915863226252 0.432474382171715 1.01371179923092 0.416666666666667 21.2 21 2 abnormal lung saccule morphology 0.130915863226252 0.432474382171715 1.01371179923092 0.416666666666667 21.2 21 2 abnormal rectum morphology 0.253674836088768 0.588630595019537 1.01371179923092 0.416666666666667 21.2 21 2 amyloidosis 0.253674836088768 0.588630595019537 1.01371179923092 0.416666666666667 21.2 21 2 abnormal enteric nervous system morphology 0.253674836088768 0.588630595019537 1.01371179923092 0.416666666666667 21.2 21 2 abnormal thymus involution 0.253674836088768 0.588630595019537 1.01371179923092 0.416666666666667 21.2 21 2 abnormal gastrocnemius morphology 0.253674836088768 0.588630595019537 1.01371179923092 0.416666666666667 21.2 21 2 small intestinal inflammation 0.253674836088768 0.588630595019537 1.01371179923092 0.416666666666667 21.2 21 2 absent ovary 0.253674836088768 0.588630595019537 1.01371179923092 0.416666666666667 21.2 21 2 abnormal nucleotide metabolism 0.253674836088768 0.588630595019537 1.01371179923092 0.416666666666667 21.2 21 2 pale placenta 0.253674836088768 0.588630595019537 1.01371179923092 0.416666666666667 21.2 21 2 decreased cochlear nerve compound action potential 0.253674836088768 0.588630595019537 1.01371179923092 0.416666666666667 21.2 21 2 abnormal cochlear outer hair cell physiology 0.253674836088768 0.588630595019537 1.01371179923092 0.416666666666667 21.2 21 2 hematuria 0.253674836088768 0.588630595019537 1.01371179923092 0.416666666666667 21.2 21 2 abnormal amacrine cell morphology 0.253674836088768 0.588630595019537 1.01371179923092 0.416666666666667 21.2 21 2 abnormal patella morphology 0.253674836088768 0.588630595019537 1.01371179923092 0.416666666666667 21.2 21 2 decreased oligodendrocyte number 0.253674836088768 0.588630595019537 1.01371179923092 0.416666666666667 21.2 21 2 increased type II pneumocyte number 0.253674836088768 0.588630595019537 1.01371179923092 0.416666666666667 21.2 21 2 abnormal colon goblet cell morphology 0.253674836088768 0.588630595019537 1.01371179923092 0.416666666666667 21.2 21 2 increased spleen weight 0.00308376014064246 0.0348675152265823 1.01191761905529 0.415929203539823 21.2 21 2 abnormal lipid homeostasis 0.00165469138896969 0.0212715495093649 1.01059268600252 0.415384615384615 21.2 21 2 sparse hair 0.0113048437158915 0.0877404016951021 1.00876686362492 0.414634146341463 21.2 21 2 Leydig cell hyperplasia 0.0617540684439289 0.289946103708802 1.00876686362492 0.414634146341463 21.2 21 2 abnormal middle ear morphology 0.108155289314752 0.377329989018857 1.00672068337416 0.413793103448276 21.2 21 2 decreased retinal photoreceptor cell number 0.108155289314752 0.377329989018857 1.00672068337416 0.413793103448276 21.2 21 2 abnormal liver morphology 0.00031288409583136 0.00553949600270824 1.00578332705817 0.41340782122905 21.2 21 2 abnormal limb morphology 0.0158621551627876 0.115371669495422 1.00560210483708 0.413333333333333 21.2 21 2 abnormal forelimb morphology 0.052032382441968 0.251810411136956 1.00489691402022 0.41304347826087 21.2 21 2 abnormal sleep pattern 0.052032382441968 0.251810411136956 1.00489691402022 0.41304347826087 21.2 21 2 skin lesions 0.0262276382146402 0.158459302253348 1.00405740114301 0.412698412698413 21.2 21 2 decreased circulating alanine transaminase level 0.0223338769960197 0.148345845200532 1.0017857780635 0.411764705882353 21.2 21 2 lung hemorrhage 0.0899490776961963 0.327778646203253 1.0017857780635 0.411764705882353 21.2 21 2 distended urinary bladder 0.200960390694222 0.543093901411143 1.0017857780635 0.411764705882353 21.2 21 2 coloboma 0.200960390694222 0.543093901411143 1.0017857780635 0.411764705882353 21.2 21 2 abnormal seminal vesicle morphology 0.0372208913231943 0.201057474845702 0.999230202099055 0.410714285714286 21.2 21 2 acanthosis 0.0751908332848085 0.317918983497174 0.998116233088911 0.41025641025641 21.2 21 2 abnormal lens fiber morphology 0.0751908332848085 0.317918983497174 0.998116233088911 0.41025641025641 21.2 21 2 decreased B-1 B cell number 0.0751908332848085 0.317918983497174 0.998116233088911 0.41025641025641 21.2 21 2 decreased circulating cholesterol level 0.000390678421890422 0.00667912422304071 0.997093573014024 0.409836065573771 21.2 21 2 increased double-negative T cell number 0.0315778272273889 0.178319739450919 0.997093573014024 0.409836065573771 21.2 21 2 spleen hypoplasia 0.00626392087876975 0.0591328394153312 0.996333882672681 0.40952380952381 21.2 21 2 teratozoospermia 0.0118769635152718 0.0913259559327313 0.995280675608544 0.409090909090909 21.2 21 2 impaired swimming 0.026835847962072 0.159305763271438 0.995280675608544 0.409090909090909 21.2 21 2 decreased sensitivity to induced morbidity/mortality 0.0631097058116784 0.289946103708802 0.995280675608544 0.409090909090909 21.2 21 2 abnormal abdominal fat pad morphology 0.16250675660824 0.490279632580954 0.995280675608544 0.409090909090909 21.2 21 2 abnormal basisphenoid bone morphology 0.16250675660824 0.490279632580954 0.995280675608544 0.409090909090909 21.2 21 2 abnormal facial nerve morphology 0.16250675660824 0.490279632580954 0.995280675608544 0.409090909090909 21.2 21 2 abnormal cochlear sensory epithelium morphology 0.16250675660824 0.490279632580954 0.995280675608544 0.409090909090909 21.2 21 2 abnormal limb posture 0.16250675660824 0.490279632580954 0.995280675608544 0.409090909090909 21.2 21 2 abnormal sperm midpiece morphology 0.16250675660824 0.490279632580954 0.995280675608544 0.409090909090909 21.2 21 2 failure of palatal shelf elevation 0.16250675660824 0.490279632580954 0.995280675608544 0.409090909090909 21.2 21 2 rough coat 0.16250675660824 0.490279632580954 0.995280675608544 0.409090909090909 21.2 21 2 cardiac hypertrophy 0.00870788789021368 0.0738019459179098 0.993023803328253 0.408163265306122 21.2 21 2 abnormal long bone hypertrophic chondrocyte zone 0.053145408166883 0.256448502066191 0.993023803328253 0.408163265306122 21.2 21 2 abnormal chondrocyte morphology 0.0448779821482432 0.22926612043297 0.991184870359127 0.407407407407407 21.2 21 2 abnormal small intestine morphology 0.0448779821482432 0.22926612043297 0.991184870359127 0.407407407407407 21.2 21 2 rectal prolapse 0.133105060086352 0.438141803083976 0.991184870359127 0.407407407407407 21.2 21 2 abnormal type II pneumocyte morphology 0.133105060086352 0.438141803083976 0.991184870359127 0.407407407407407 21.2 21 2 decreased circulating HDL cholesterol level 0.00348432163279171 0.0377597321442046 0.988369004250152 0.40625 21.2 21 2 kidney cortex cysts 0.109992077306689 0.382397333753166 0.988369004250152 0.40625 21.2 21 2 polydipsia 0.109992077306689 0.382397333753166 0.988369004250152 0.40625 21.2 21 2 increased circulating follicle stimulating hormone level 0.109992077306689 0.382397333753166 0.988369004250152 0.40625 21.2 21 2 abnormal long term potentiation 0.109992077306689 0.382397333753166 0.988369004250152 0.40625 21.2 21 2 abnormal lumbar vertebrae morphology 0.109992077306689 0.382397333753166 0.988369004250152 0.40625 21.2 21 2 increased susceptibility to pharmacologically induced seizures 0.010377803189912 0.081692358971222 0.988369004250152 0.40625 21.2 21 2 increased lymphocyte cell number 0.0273702121213966 0.159305763271438 0.987267143598814 0.405797101449275 21.2 21 2 increased white adipose tissue amount 0.0914879598229689 0.331260989897577 0.986314183035495 0.405405405405405 21.2 21 2 impaired skeletal muscle contractility 0.0914879598229689 0.331260989897577 0.986314183035495 0.405405405405405 21.2 21 2 abnormal calcium ion homeostasis 0.0914879598229689 0.331260989897577 0.986314183035495 0.405405405405405 21.2 21 2 hunched posture 0.0198431335294542 0.137684224977733 0.985481850391583 0.40506329113924 21.2 21 2 abnormal spleen white pulp morphology 0.0764812733134457 0.317918983497174 0.984748604967184 0.404761904761905 21.2 21 2 abnormal tibia morphology 0.0641936739022271 0.291390079985018 0.983516128615536 0.404255319148936 21.2 21 2 abnormal brain wave pattern 0.054057726492982 0.258842338116059 0.982520666946897 0.403846153846154 21.2 21 2 abnormal lung morphology 0.00570654635065303 0.0543704077092935 0.981341170347921 0.403361344537815 21.2 21 2 abnormal neuromuscular synapse morphology 0.0278365427050776 0.160471378861832 0.979921405923227 0.402777777777778 21.2 21 2 short limbs 0.0172138530337821 0.121646191538446 0.9787562199471 0.402298850574713 21.2 21 2 female infertility 6.60262368466453e-05 0.0015792333091926 0.978651090385344 0.402255639097744 21.2 21 2 increased monocyte cell number 0.0127533239838057 0.0971026531291419 0.973163327261688 0.4 21.2 21 2 abnormal social investigation 0.0240314676859298 0.153799467871333 0.973163327261688 0.4 21.2 21 2 abnormal incisor morphology 0.0462825757064296 0.235676370664777 0.973163327261688 0.4 21.2 21 2 kidney inflammation 0.0650437271244102 0.294979528207786 0.973163327261688 0.4 21.2 21 2 abnormal cartilage development 0.0774564244095499 0.31794200613656 0.973163327261688 0.4 21.2 21 2 abnormal autopod morphology 0.0774564244095499 0.31794200613656 0.973163327261688 0.4 21.2 21 2 abnormal metabolism 0.0774564244095499 0.31794200613656 0.973163327261688 0.4 21.2 21 2 abnormal lactation 0.134418246830884 0.438141803083976 0.973163327261688 0.4 21.2 21 2 abnormal spleen marginal zone morphology 0.134418246830884 0.438141803083976 0.973163327261688 0.4 21.2 21 2 decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 0.163781357962714 0.49278650688452 0.973163327261688 0.4 21.2 21 2 abnormal cell proliferation 0.201855947908599 0.543093901411143 0.973163327261688 0.4 21.2 21 2 abnormal male reproductive system physiology 0.201855947908599 0.543093901411143 0.973163327261688 0.4 21.2 21 2 nuclear cataracts 0.201855947908599 0.543093901411143 0.973163327261688 0.4 21.2 21 2 decreased salivation 0.25315916593335 0.588630595019537 0.973163327261688 0.4 21.2 21 2 vagina atresia 0.25315916593335 0.588630595019537 0.973163327261688 0.4 21.2 21 2 hyperpigmentation 0.25315916593335 0.588630595019537 0.973163327261688 0.4 21.2 21 2 abnormal apical ectodermal ridge morphology 0.25315916593335 0.588630595019537 0.973163327261688 0.4 21.2 21 2 placental labyrinth hypoplasia 0.25315916593335 0.588630595019537 0.973163327261688 0.4 21.2 21 2 abnormal cricoid cartilage morphology 0.25315916593335 0.588630595019537 0.973163327261688 0.4 21.2 21 2 abnormal lymph node B cell domain morphology 0.25315916593335 0.588630595019537 0.973163327261688 0.4 21.2 21 2 arthritis 0.25315916593335 0.588630595019537 0.973163327261688 0.4 21.2 21 2 abnormal pericyte morphology 0.25315916593335 0.588630595019537 0.973163327261688 0.4 21.2 21 2 abnormal energy homeostasis 0.25315916593335 0.588630595019537 0.973163327261688 0.4 21.2 21 2 absent chorion 0.25315916593335 0.588630595019537 0.973163327261688 0.4 21.2 21 2 decreased trabecular bone mass 0.25315916593335 0.588630595019537 0.973163327261688 0.4 21.2 21 2 herniated liver 0.25315916593335 0.588630595019537 0.973163327261688 0.4 21.2 21 2 weight loss 0.00130575052898301 0.0174626582841141 0.973163327261688 0.4 21.2 21 2 increased bone mineral density 0.00946958378313739 0.0771487554212405 0.968857294840176 0.398230088495575 21.2 21 2 abnormal heart ventricle morphology 0.0285863185524283 0.164033373469816 0.966925100804882 0.397435897435897 21.2 21 2 abnormal inhibitory postsynaptic currents 0.0396357706545444 0.211348294754939 0.966007714561234 0.397058823529412 21.2 21 2 increased circulating aspartate transaminase level 0.0467982322390721 0.237815327261883 0.965439808791357 0.396825396825397 21.2 21 2 abnormal pancreatic islet morphology 0.0656917532350897 0.29710588394961 0.963982541155446 0.39622641509434 21.2 21 2 retinal degeneration 0.0178942690616696 0.125760015145177 0.963026209269379 0.395833333333333 21.2 21 2 abnormal osteoclast morphology 0.0781650479266676 0.318061135517257 0.963026209269379 0.395833333333333 21.2 21 2 abnormal phalanx morphology 0.0781650479266676 0.318061135517257 0.963026209269379 0.395833333333333 21.2 21 2 impaired macrophage phagocytosis 0.0933447062830163 0.337247577166308 0.96184747461911 0.395348837209302 21.2 21 2 kidney failure 0.0933447062830163 0.337247577166308 0.96184747461911 0.395348837209302 21.2 21 2 abnormal axial skeleton morphology 0.0339633001288205 0.186087464912865 0.960358546639824 0.394736842105263 21.2 21 2 increased bone marrow cell number 0.111970182911353 0.386841332200575 0.960358546639824 0.394736842105263 21.2 21 2 hyporesponsive to tactile stimuli 0.111970182911353 0.386841332200575 0.960358546639824 0.394736842105263 21.2 21 2 abnormal renal glomerulus morphology 0.0132085574003356 0.0998671323201662 0.95977117138194 0.394495412844037 21.2 21 2 cachexia 0.0154413427060422 0.112805697448693 0.959127317733875 0.394230769230769 21.2 21 2 abnormal ovarian folliculogenesis 0.135068835604852 0.438141803083976 0.958418428363784 0.393939393939394 21.2 21 2 absent vibrissae 0.135068835604852 0.438141803083976 0.958418428363784 0.393939393939394 21.2 21 2 decreased B cell number 0.00105430781803996 0.0147651622614863 0.956628998885882 0.393203883495146 21.2 21 2 increased leukocyte cell number 0.00535630377961005 0.0523528709303733 0.956384649205452 0.393103448275862 21.2 21 2 increased body weight 0.000683874748932063 0.0104685442336524 0.955785410703443 0.392857142857143 21.2 21 2 abnormal coat/hair pigmentation 0.0133269845071954 0.100609632660542 0.955785410703443 0.392857142857143 21.2 21 2 hydronephrosis 0.0291237441970946 0.166732597676117 0.955785410703443 0.392857142857143 21.2 21 2 reddish skin 0.164130098875909 0.49278650688452 0.955785410703443 0.392857142857143 21.2 21 2 abnormal retinal inner nuclear layer morphology 0.164130098875909 0.49278650688452 0.955785410703443 0.392857142857143 21.2 21 2 decreased circulating progesterone level 0.164130098875909 0.49278650688452 0.955785410703443 0.392857142857143 21.2 21 2 abnormal renal tubule epithelium morphology 0.164130098875909 0.49278650688452 0.955785410703443 0.392857142857143 21.2 21 2 decreased food intake 0.0342329588797654 0.186742292134685 0.954685542566846 0.392405063291139 21.2 21 2 decreased litter size 0.000190032664918681 0.00366438956577689 0.952384039135104 0.391459074733096 21.2 21 2 abnormal skeleton morphology 0.0134302449307826 0.101235558379762 0.952007602755999 0.391304347826087 21.2 21 2 abnormal immune system morphology 0.0938004513887097 0.338331265374719 0.952007602755999 0.391304347826087 21.2 21 2 abnormal carpal bone morphology 0.201445354741372 0.543093901411143 0.952007602755999 0.391304347826087 21.2 21 2 abnormal cranial nerve morphology 0.201445354741372 0.543093901411143 0.952007602755999 0.391304347826087 21.2 21 2 blistering 0.201445354741372 0.543093901411143 0.952007602755999 0.391304347826087 21.2 21 2 abnormal cochlear ganglion morphology 0.201445354741372 0.543093901411143 0.952007602755999 0.391304347826087 21.2 21 2 abnormal cardiovascular development 0.201445354741372 0.543093901411143 0.952007602755999 0.391304347826087 21.2 21 2 decreased effector memory CD8-positive, alpha-beta T cell number 0.201445354741372 0.543093901411143 0.952007602755999 0.391304347826087 21.2 21 2 abnormal cardiovascular system physiology 0.00852427062611079 0.072741417435508 0.951212274767063 0.390977443609023 21.2 21 2 decreased hematocrit 0.00633181810708995 0.0595478167916304 0.949834069416373 0.39041095890411 21.2 21 2 increased tumor growth/size 0.112332000999558 0.386841332200575 0.949427636352866 0.390243902439024 21.2 21 2 decreased heart rate 0.0214650229897546 0.145885914445395 0.948834244080146 0.39 21.2 21 2 abnormal thoracic vertebrae morphology 0.0664859067742556 0.300424510628448 0.948421886738086 0.389830508474576 21.2 21 2 polyuria 0.0405239923410571 0.215003496315561 0.947886357722423 0.38961038961039 21.2 21 2 cochlear outer hair cell degeneration 0.0477491394240994 0.241906281705595 0.94613101261553 0.388888888888889 21.2 21 2 diluted coat color 0.0789368802903555 0.318061135517257 0.94613101261553 0.388888888888889 21.2 21 2 abnormal mandible morphology 0.0789368802903555 0.318061135517257 0.94613101261553 0.388888888888889 21.2 21 2 abnormal long bone epiphyseal plate proliferative zone 0.0789368802903555 0.318061135517257 0.94613101261553 0.388888888888889 21.2 21 2 abnormal osteoblast physiology 0.0789368802903555 0.318061135517257 0.94613101261553 0.388888888888889 21.2 21 2 decreased platelet aggregation 0.0789368802903555 0.318061135517257 0.94613101261553 0.388888888888889 21.2 21 2 lowered ear position 0.250858725403966 0.588630595019537 0.94613101261553 0.388888888888889 21.2 21 2 abnormal heart shape 0.250858725403966 0.588630595019537 0.94613101261553 0.388888888888889 21.2 21 2 cortical renal glomerulopathies 0.250858725403966 0.588630595019537 0.94613101261553 0.388888888888889 21.2 21 2 delayed kidney development 0.250858725403966 0.588630595019537 0.94613101261553 0.388888888888889 21.2 21 2 abnormal retinal rod cell morphology 0.250858725403966 0.588630595019537 0.94613101261553 0.388888888888889 21.2 21 2 abnormal thyroid cartilage morphology 0.250858725403966 0.588630595019537 0.94613101261553 0.388888888888889 21.2 21 2 absent allantois 0.250858725403966 0.588630595019537 0.94613101261553 0.388888888888889 21.2 21 2 abnormal neutrophil morphology 0.250858725403966 0.588630595019537 0.94613101261553 0.388888888888889 21.2 21 2 abnormal eye anterior chamber morphology 0.250858725403966 0.588630595019537 0.94613101261553 0.388888888888889 21.2 21 2 decreased pulmonary respiratory rate 0.250858725403966 0.588630595019537 0.94613101261553 0.388888888888889 21.2 21 2 abnormal sperm axoneme morphology 0.250858725403966 0.588630595019537 0.94613101261553 0.388888888888889 21.2 21 2 maternal effect 0.0563650461061245 0.267828179921652 0.944113675701638 0.388059701492537 21.2 21 2 increased circulating insulin level 0.00554068949764098 0.0536177736585854 0.94275197328476 0.3875 21.2 21 2 abnormal CD8-positive, alpha beta T cell morphology 0.163810560857939 0.49278650688452 0.94177096186615 0.387096774193548 21.2 21 2 abnormal T cell proliferation 0.163810560857939 0.49278650688452 0.94177096186615 0.387096774193548 21.2 21 2 abnormal trabecular bone morphology 0.0159336580403245 0.115697112514325 0.940451954916757 0.38655462184874 21.2 21 2 hyperglycemia 0.0347287194530532 0.189032143631225 0.939987304741403 0.386363636363636 21.2 21 2 abnormal myelopoiesis 0.112381558431637 0.386841332200575 0.939987304741403 0.386363636363636 21.2 21 2 abnormal action potential 0.0564903268373318 0.268167343526456 0.938407494145199 0.385714285714286 21.2 21 2 absent corpus luteum 0.094015925013431 0.338688795758015 0.935733968520854 0.384615384615385 21.2 21 2 abnormal iris morphology 0.134957276427943 0.438141803083976 0.935733968520854 0.384615384615385 21.2 21 2 increased autoantibody level 0.134957276427943 0.438141803083976 0.935733968520854 0.384615384615385 21.2 21 2 impaired macrophage chemotaxis 0.134957276427943 0.438141803083976 0.935733968520854 0.384615384615385 21.2 21 2 abnormal circulating hormone level 0.134957276427943 0.438141803083976 0.935733968520854 0.384615384615385 21.2 21 2 abnormal erythrocyte osmotic lysis 0.200178967499175 0.543093901411143 0.935733968520854 0.384615384615385 21.2 21 2 absent common myeloid progenitor cells 0.319752665159044 0.616358865454071 0.935733968520854 0.384615384615385 21.2 21 2 small trigeminal ganglion 0.319752665159044 0.616358865454071 0.935733968520854 0.384615384615385 21.2 21 2 abnormal lung interstitium morphology 0.319752665159044 0.616358865454071 0.935733968520854 0.384615384615385 21.2 21 2 dystrophic cardiac calcinosis 0.319752665159044 0.616358865454071 0.935733968520854 0.384615384615385 21.2 21 2 abnormal otolith morphology 0.319752665159044 0.616358865454071 0.935733968520854 0.384615384615385 21.2 21 2 muscle fatigue 0.319752665159044 0.616358865454071 0.935733968520854 0.384615384615385 21.2 21 2 abnormal vestibulocochlear ganglion morphology 0.319752665159044 0.616358865454071 0.935733968520854 0.384615384615385 21.2 21 2 decreased endocochlear potential 0.319752665159044 0.616358865454071 0.935733968520854 0.384615384615385 21.2 21 2 increased circulating thyroid-stimulating hormone level 0.319752665159044 0.616358865454071 0.935733968520854 0.384615384615385 21.2 21 2 abnormal exocrine pancreas morphology 0.319752665159044 0.616358865454071 0.935733968520854 0.384615384615385 21.2 21 2 hyperalgesia 0.319752665159044 0.616358865454071 0.935733968520854 0.384615384615385 21.2 21 2 orthokeratosis 0.319752665159044 0.616358865454071 0.935733968520854 0.384615384615385 21.2 21 2 decreased cardiac stroke volume 0.319752665159044 0.616358865454071 0.935733968520854 0.384615384615385 21.2 21 2 decreased bone trabecula number 0.112177071897561 0.386841332200575 0.931752121846297 0.382978723404255 21.2 21 2 abnormal lens morphology 0.0160482195083172 0.116215272276387 0.931347715543412 0.3828125 21.2 21 2 abnormal endoderm development 0.16300011431021 0.491470041632301 0.930229651058966 0.382352941176471 21.2 21 2 decreased circulating calcium level 0.0938486726064548 0.338331265374719 0.928928630567975 0.381818181818182 21.2 21 2 increased food intake 0.0479754320665778 0.242805467478357 0.926822216439703 0.380952380952381 21.2 21 2 abnormal cartilage morphology 0.134393987267935 0.438141803083976 0.926822216439703 0.380952380952381 21.2 21 2 increased keratinocyte proliferation 0.247584872480652 0.588630595019537 0.926822216439703 0.380952380952381 21.2 21 2 vascular ring 0.247584872480652 0.588630595019537 0.926822216439703 0.380952380952381 21.2 21 2 increased bone ossification 0.247584872480652 0.588630595019537 0.926822216439703 0.380952380952381 21.2 21 2 decreased vocalization 0.247584872480652 0.588630595019537 0.926822216439703 0.380952380952381 21.2 21 2 increased body length 0.111764844302025 0.386841332200575 0.924505160898604 0.38 21.2 21 2 abnormal circulating protein level 0.111764844302025 0.386841332200575 0.924505160898604 0.38 21.2 21 2 cochlear ganglion degeneration 0.0935362618333444 0.337694414093533 0.92282729309298 0.379310344827586 21.2 21 2 aphagia 0.198336926941062 0.543093901411143 0.92282729309298 0.379310344827586 21.2 21 2 decreased bone strength 0.198336926941062 0.543093901411143 0.92282729309298 0.379310344827586 21.2 21 2 increased double-positive T cell number 0.198336926941062 0.543093901411143 0.92282729309298 0.379310344827586 21.2 21 2 polychromatophilia 0.198336926941062 0.543093901411143 0.92282729309298 0.379310344827586 21.2 21 2 abnormal long bone metaphysis morphology 0.161824511687184 0.490279632580954 0.920559904166462 0.378378378378378 21.2 21 2 skin inflammation 0.161824511687184 0.490279632580954 0.920559904166462 0.378378378378378 21.2 21 2 albuminuria 0.133586104087903 0.438141803083976 0.919098697969372 0.377777777777778 21.2 21 2 abnormal long bone morphology 0.0931013314303357 0.33685754462976 0.917326087172902 0.377049180327869 21.2 21 2 abnormal epidermal layer morphology 0.0783308638597185 0.318061135517257 0.916748061913184 0.376811594202899 21.2 21 2 short mandible 0.110458996455799 0.383752449279051 0.912340619307833 0.375 21.2 21 2 perinatal lethality 0.160375079551658 0.486800500774557 0.912340619307833 0.375 21.2 21 2 abnormal lymphatic vessel morphology 0.196101650988688 0.543093901411143 0.912340619307833 0.375 21.2 21 2 abnormal serotonin level 0.196101650988688 0.543093901411143 0.912340619307833 0.375 21.2 21 2 abnormal tympanic ring morphology 0.311811004094718 0.616358865454071 0.912340619307833 0.375 21.2 21 2 delayed hair appearance 0.311811004094718 0.616358865454071 0.912340619307833 0.375 21.2 21 2 abnormal meiosis 0.311811004094718 0.616358865454071 0.912340619307833 0.375 21.2 21 2 impaired muscle relaxation 0.311811004094718 0.616358865454071 0.912340619307833 0.375 21.2 21 2 abnormal pulmonary elastic fiber morphology 0.311811004094718 0.616358865454071 0.912340619307833 0.375 21.2 21 2 decreased aggression towards mice 0.311811004094718 0.616358865454071 0.912340619307833 0.375 21.2 21 2 abnormal molar crown morphology 0.311811004094718 0.616358865454071 0.912340619307833 0.375 21.2 21 2 bowed radius 0.311811004094718 0.616358865454071 0.912340619307833 0.375 21.2 21 2 small epididymis 0.311811004094718 0.616358865454071 0.912340619307833 0.375 21.2 21 2 decreased skeletal muscle weight 0.311811004094718 0.616358865454071 0.912340619307833 0.375 21.2 21 2 increased heart left ventricle size 0.311811004094718 0.616358865454071 0.912340619307833 0.375 21.2 21 2 lung inflammation 0.0215664877240074 0.145888372130068 0.912340619307832 0.375 21.2 21 2 abnormal body weight 0.243763049650445 0.588630595019537 0.912340619307832 0.375 21.2 21 2 apnea 0.243763049650445 0.588630595019537 0.912340619307832 0.375 21.2 21 2 abnormal impulse conducting system conduction 0.243763049650445 0.588630595019537 0.912340619307832 0.375 21.2 21 2 abnormal osteoblast morphology 0.243763049650445 0.588630595019537 0.912340619307832 0.375 21.2 21 2 increased circulating total protein level 0.243763049650445 0.588630595019537 0.912340619307832 0.375 21.2 21 2 abnormal truncus arteriosus septation 0.243763049650445 0.588630595019537 0.912340619307832 0.375 21.2 21 2 deafness 0.0471710237922209 0.23927068553235 0.909268765370769 0.373737373737374 21.2 21 2 abnormal blood circulation 0.15871948711085 0.485626967021203 0.905268211406221 0.372093023255814 21.2 21 2 abnormal artery morphology 0.193596249341419 0.543093901411143 0.90365166102871 0.371428571428571 21.2 21 2 decreased bone mineralization 0.193596249341419 0.543093901411143 0.90365166102871 0.371428571428571 21.2 21 2 abnormal single cell response 0.239634207153777 0.588630595019537 0.901077154871933 0.37037037037037 21.2 21 2 abnormal fetal cardiomyocyte proliferation 0.239634207153777 0.588630595019537 0.901077154871933 0.37037037037037 21.2 21 2 thick interventricular septum 0.239634207153777 0.588630595019537 0.901077154871933 0.37037037037037 21.2 21 2 delayed wound healing 0.156908728083983 0.480382105980193 0.899118291491777 0.369565217391304 21.2 21 2 abnormal lymphocyte physiology 0.156908728083983 0.480382105980193 0.899118291491777 0.369565217391304 21.2 21 2 increased macrophage cell number 0.128774209193869 0.427101127159666 0.896334643530502 0.368421052631579 21.2 21 2 abnormal reproductive system physiology 0.190906203473086 0.543093901411143 0.896334643530502 0.368421052631579 21.2 21 2 decreased threshold for auditory brainstem response 0.190906203473086 0.543093901411143 0.896334643530502 0.368421052631579 21.2 21 2 decreased grooming behavior 0.303907162911038 0.610144526021958 0.896334643530502 0.368421052631579 21.2 21 2 increased susceptibility to ischemic brain injury 0.303907162911038 0.610144526021958 0.896334643530502 0.368421052631579 21.2 21 2 abnormal response to novelty 0.303907162911038 0.610144526021958 0.896334643530502 0.368421052631579 21.2 21 2 Leydig cell hypoplasia 0.303907162911038 0.610144526021958 0.896334643530502 0.368421052631579 21.2 21 2 shortened RR interval 0.303907162911038 0.610144526021958 0.896334643530502 0.368421052631579 21.2 21 2 thin interventricular septum 0.303907162911038 0.610144526021958 0.896334643530502 0.368421052631579 21.2 21 2 increased B cell number 0.045277223525418 0.230793224425158 0.894145792142149 0.367521367521368 21.2 21 2 abnormal hair cycle 0.235342478583795 0.588630595019537 0.892066383323214 0.366666666666667 21.2 21 2 gastrointestinal hemorrhage 0.235342478583795 0.588630595019537 0.892066383323214 0.366666666666667 21.2 21 2 arrested T cell differentiation 0.235342478583795 0.588630595019537 0.892066383323214 0.366666666666667 21.2 21 2 abnormal T cell differentiation 0.062466414536876 0.289946103708802 0.891263443284219 0.366336633663366 21.2 21 2 abnormal CD4-positive, alpha-beta T cell physiology 0.105467607914544 0.369259693357431 0.890924172845207 0.366197183098592 21.2 21 2 arrested B cell differentiation 0.188092240254793 0.543093901411143 0.890088409080812 0.365853658536585 21.2 21 2 abnormal hair growth 0.152968812694417 0.472683132394238 0.888947270094811 0.365384615384615 21.2 21 2 abnormal female meiosis 0.152968812694417 0.472683132394238 0.888947270094811 0.365384615384615 21.2 21 2 abnormal aorta morphology 0.230977545493738 0.588630595019537 0.884693933874262 0.363636363636364 21.2 21 2 decreased systemic arterial blood pressure 0.230977545493738 0.588630595019537 0.884693933874262 0.363636363636364 21.2 21 2 dilated heart atrium 0.230977545493738 0.588630595019537 0.884693933874262 0.363636363636364 21.2 21 2 increased body size 0.29620093869346 0.596357616349641 0.884693933874262 0.363636363636364 21.2 21 2 increased coping response 0.29620093869346 0.596357616349641 0.884693933874262 0.363636363636364 21.2 21 2 abnormal tracheal cartilage morphology 0.29620093869346 0.596357616349641 0.884693933874262 0.363636363636364 21.2 21 2 decreased cardiac output 0.29620093869346 0.596357616349641 0.884693933874262 0.363636363636364 21.2 21 2 parakeratosis 0.29620093869346 0.596357616349641 0.884693933874262 0.363636363636364 21.2 21 2 abnormal female reproductive system physiology 0.29620093869346 0.596357616349641 0.884693933874262 0.363636363636364 21.2 21 2 abnormal basement membrane morphology 0.29620093869346 0.596357616349641 0.884693933874262 0.363636363636364 21.2 21 2 decreased susceptibility to viral infection induced morbidity/mortality 0.29620093869346 0.596357616349641 0.884693933874262 0.363636363636364 21.2 21 2 small ovary 0.0850483180472276 0.318061135517257 0.882263456033948 0.362637362637363 21.2 21 2 abnormal coat appearance 0.122657221462565 0.408173696840308 0.88148852107037 0.36231884057971 21.2 21 2 abnormal enzyme/coenzyme level 0.148774125263357 0.469482447580993 0.88088059795239 0.362068965517241 21.2 21 2 abnormal heart left ventricle morphology 0.121037832500747 0.405497115616981 0.878550226000135 0.361111111111111 21.2 21 2 abnormal systemic arterial blood pressure 0.226596787826699 0.588630595019537 0.878550226000135 0.361111111111111 21.2 21 2 abnormal reflex 0.226596787826699 0.588630595019537 0.878550226000135 0.361111111111111 21.2 21 2 abnormal limb bone morphology 0.226596787826699 0.588630595019537 0.878550226000135 0.361111111111111 21.2 21 2 narrow eye opening 0.226596787826699 0.588630595019537 0.878550226000135 0.361111111111111 21.2 21 2 abnormal male meiosis 0.146625771443224 0.469482447580993 0.877442344252341 0.360655737704918 21.2 21 2 decreased T cell number 0.034510769369485 0.188051563650808 0.87645144380711 0.360248447204969 21.2 21 2 abnormal inner ear vestibule morphology 0.288752751224792 0.588630595019537 0.875846994535519 0.36 21.2 21 2 abnormal energy expenditure 0.288752751224792 0.588630595019537 0.875846994535519 0.36 21.2 21 2 increased urine protein level 0.117751700749114 0.394753848535606 0.873351703952797 0.358974358974359 21.2 21 2 decreased T cell proliferation 0.0463317586071315 0.235685581871656 0.871244195014687 0.358108108108108 21.2 21 2 abnormal skeleton development 0.116096852212608 0.389468536586462 0.871041249709536 0.358024691358025 21.2 21 2 thick epidermis 0.140113102421444 0.45175805868223 0.868895827912221 0.357142857142857 21.2 21 2 dehydration 0.140113102421444 0.45175805868223 0.868895827912221 0.357142857142857 21.2 21 2 abnormal circulating cholesterol level 0.281580933974815 0.588630595019537 0.868895827912221 0.357142857142857 21.2 21 2 myoclonus 0.281580933974815 0.588630595019537 0.868895827912221 0.357142857142857 21.2 21 2 enhanced coordination 0.281580933974815 0.588630595019537 0.868895827912221 0.357142857142857 21.2 21 2 hypoxia 0.281580933974815 0.588630595019537 0.868895827912221 0.357142857142857 21.2 21 2 absent atrioventricular cushions 0.387398657021321 0.70494086272168 0.868895827912221 0.357142857142857 21.2 21 2 increased aggression towards males 0.387398657021321 0.70494086272168 0.868895827912221 0.357142857142857 21.2 21 2 absent visceral yolk sac blood islands 0.387398657021321 0.70494086272168 0.868895827912221 0.357142857142857 21.2 21 2 abnormal antigen presentation 0.387398657021321 0.70494086272168 0.868895827912221 0.357142857142857 21.2 21 2 abnormal olfactory system physiology 0.387398657021321 0.70494086272168 0.868895827912221 0.357142857142857 21.2 21 2 absent otoliths 0.387398657021321 0.70494086272168 0.868895827912221 0.357142857142857 21.2 21 2 intestinal obstruction 0.387398657021321 0.70494086272168 0.868895827912221 0.357142857142857 21.2 21 2 abnormal vascular endothelial cell migration 0.387398657021321 0.70494086272168 0.868895827912221 0.357142857142857 21.2 21 2 enlarged stomach 0.387398657021321 0.70494086272168 0.868895827912221 0.357142857142857 21.2 21 2 increased B-1 B cell number 0.387398657021321 0.70494086272168 0.868895827912221 0.357142857142857 21.2 21 2 premature hair loss 0.387398657021321 0.70494086272168 0.868895827912221 0.357142857142857 21.2 21 2 increased circulating growth hormone level 0.387398657021321 0.70494086272168 0.868895827912221 0.357142857142857 21.2 21 2 altered response to myocardial infarction 0.213673999725767 0.564839611389845 0.865034068677056 0.355555555555556 21.2 21 2 increased circulating corticosterone level 0.213673999725767 0.564839611389845 0.865034068677056 0.355555555555556 21.2 21 2 abnormal eyelid morphology 0.274685033333017 0.588630595019537 0.863290048377304 0.354838709677419 21.2 21 2 decreased double-negative T cell number 0.274685033333017 0.588630595019537 0.863290048377304 0.354838709677419 21.2 21 2 abnormal podocyte morphology 0.274685033333017 0.588630595019537 0.863290048377304 0.354838709677419 21.2 21 2 increased circulating glucose level 0.0606890511534742 0.287276907220299 0.862733446153979 0.354609929078014 21.2 21 2 abnormal urine homeostasis 0.107867751473845 0.376855381729198 0.861655029346286 0.354166666666667 21.2 21 2 abnormal response/metabolism to endogenous compounds 0.131524166134195 0.434195571677254 0.860418795444785 0.353658536585366 21.2 21 2 circling 0.129421890674742 0.428963295207756 0.858673524054431 0.352941176470588 21.2 21 2 abnormal retinal photoreceptor morphology 0.268056144321116 0.588630595019537 0.85867352405443 0.352941176470588 21.2 21 2 abnormal vision 0.268056144321116 0.588630595019537 0.85867352405443 0.352941176470588 21.2 21 2 abnormal spleen red pulp morphology 0.268056144321116 0.588630595019537 0.85867352405443 0.352941176470588 21.2 21 2 decreased osteoblast cell number 0.268056144321116 0.588630595019537 0.85867352405443 0.352941176470588 21.2 21 2 abnormal skin physiology 0.268056144321116 0.588630595019537 0.85867352405443 0.352941176470588 21.2 21 2 increased aggression towards mice 0.372274975040443 0.681659183226427 0.85867352405443 0.352941176470588 21.2 21 2 aminoaciduria 0.372274975040443 0.681659183226427 0.85867352405443 0.352941176470588 21.2 21 2 abnormal testis development 0.372274975040443 0.681659183226427 0.85867352405443 0.352941176470588 21.2 21 2 increased circulating magnesium level 0.372274975040443 0.681659183226427 0.85867352405443 0.352941176470588 21.2 21 2 abnormal electroretinogram waveform feature 0.372274975040443 0.681659183226427 0.85867352405443 0.352941176470588 21.2 21 2 decreased body fat mass 0.372274975040443 0.681659183226427 0.85867352405443 0.352941176470588 21.2 21 2 increased brown adipose tissue amount 0.261681770735603 0.588630595019537 0.854805625297429 0.351351351351351 21.2 21 2 abnormal pancreatic beta cell physiology 0.261681770735603 0.588630595019537 0.854805625297429 0.351351351351351 21.2 21 2 abnormal cytokine secretion 0.0640991855508128 0.291226893255976 0.853097721950181 0.350649350649351 21.2 21 2 abnormal long bone epiphyseal plate morphology 0.193614051054153 0.543093901411143 0.851517911353977 0.35 21.2 21 2 abnormal eye physiology 0.193614051054153 0.543093901411143 0.851517911353977 0.35 21.2 21 2 increased urine glucose level 0.35885781714312 0.658788797153882 0.851517911353977 0.35 21.2 21 2 brain inflammation 0.35885781714312 0.658788797153882 0.851517911353977 0.35 21.2 21 2 abnormal hyoid bone morphology 0.35885781714312 0.658788797153882 0.851517911353977 0.35 21.2 21 2 decreased skin tensile strength 0.35885781714312 0.658788797153882 0.851517911353977 0.35 21.2 21 2 abnormal thymocyte activation 0.35885781714312 0.658788797153882 0.851517911353977 0.35 21.2 21 2 kidney atrophy 0.35885781714312 0.658788797153882 0.851517911353977 0.35 21.2 21 2 decreased circulating VLDL cholesterol level 0.35885781714312 0.658788797153882 0.851517911353977 0.35 21.2 21 2 enhanced behavioral response to xenobiotic 0.35885781714312 0.658788797153882 0.851517911353977 0.35 21.2 21 2 abnormal circulating cytokine level 0.35885781714312 0.658788797153882 0.851517911353977 0.35 21.2 21 2 abnormal skin morphology 0.186189843731682 0.543093901411143 0.847831686629501 0.348484848484849 21.2 21 2 abnormal retinal cone cell morphology 0.346737250134572 0.638895488673888 0.846228980227555 0.347826086956522 21.2 21 2 hypotension 0.346737250134572 0.638895488673888 0.846228980227555 0.347826086956522 21.2 21 2 failure of embryo implantation 0.346737250134572 0.638895488673888 0.846228980227555 0.347826086956522 21.2 21 2 decreased epididymis weight 0.346737250134572 0.638895488673888 0.846228980227555 0.347826086956522 21.2 21 2 abnormal B cell morphology 0.346737250134572 0.638895488673888 0.846228980227555 0.347826086956522 21.2 21 2 abnormal eye electrophysiology 0.106283213599245 0.371580455134396 0.844480573243613 0.347107438016529 21.2 21 2 organ of Corti degeneration 0.238457227547534 0.588630595019537 0.844070232829015 0.346938775510204 21.2 21 2 abnormal respiratory system physiology 0.238457227547534 0.588630595019537 0.844070232829015 0.346938775510204 21.2 21 2 increased fluid intake 0.238457227547534 0.588630595019537 0.844070232829015 0.346938775510204 21.2 21 2 abnormal leukocyte cell number 0.33564475437365 0.620294447625894 0.842160571668768 0.346153846153846 21.2 21 2 abnormal T-helper 2 physiology 0.228032009394465 0.588630595019537 0.840459237180549 0.345454545454545 21.2 21 2 glomerulosclerosis 0.223077627126934 0.588630595019537 0.8389339028118 0.344827586206897 21.2 21 2 decreased granulocyte number 0.325393569255737 0.616358865454071 0.8389339028118 0.344827586206897 21.2 21 2 enlarged epididymis 0.325393569255737 0.616358865454071 0.8389339028118 0.344827586206897 21.2 21 2 decreased eosinophil cell number 0.213639361183664 0.564839611389845 0.836312234365513 0.34375 21.2 21 2 impaired adaptive thermogenesis 0.306904785180089 0.615665849302799 0.834139994795733 0.342857142857143 21.2 21 2 decreased neutrophil cell number 0.135263254378492 0.438141803083976 0.831763527574092 0.341880341880342 21.2 21 2 abnormal response to infection 0.192436222665805 0.543093901411143 0.831500311267898 0.341772151898734 21.2 21 2 small kidney 0.181110048977254 0.530013231565788 0.82940056300712 0.340909090909091 21.2 21 2 abnormal coat/ hair morphology 0.262384655638044 0.588630595019537 0.826270749561811 0.339622641509434 21.2 21 2 obese 0.218342679543566 0.576874578188657 0.8215015100261 0.337662337662338 21.2 21 2 abnormal kidney development 0.278321597990968 0.588630595019537 0.81096943938474 0.333333333333333 21.2 21 2 abnormal food intake 0.258734921581532 0.588630595019537 0.81096943938474 0.333333333333333 21.2 21 2 polyphagia 0.292884921137415 0.591596623085116 0.81096943938474 0.333333333333333 21.2 21 2 abnormal cytotoxic T cell physiology 0.326825726647029 0.616358865454071 0.81096943938474 0.333333333333333 21.2 21 2 increased vascular permeability 0.336608797258985 0.62184506734625 0.81096943938474 0.333333333333333 21.2 21 2 head tossing 0.358282863380343 0.658788797153882 0.81096943938474 0.333333333333333 21.2 21 2 abnormal fat pad morphology 0.370419114591708 0.679762115490131 0.81096943938474 0.333333333333333 21.2 21 2 wrinkled skin 0.383650027983586 0.701197240712101 0.81096943938474 0.333333333333333 21.2 21 2 abnormal scapula morphology 0.414494289474354 0.743102374823391 0.81096943938474 0.333333333333333 21.2 21 2 abnormal associative learning 0.414494289474354 0.743102374823391 0.81096943938474 0.333333333333333 21.2 21 2 dry skin 0.414494289474354 0.743102374823391 0.81096943938474 0.333333333333333 21.2 21 2 abnormal bile salt homeostasis 0.414494289474354 0.743102374823391 0.81096943938474 0.333333333333333 21.2 21 2 decreased chondrocyte number 0.454518402565307 0.759366911100108 0.81096943938474 0.333333333333333 21.2 21 2 abnormal stomach glandular epithelium morphology 0.432983099858682 0.759366911100108 0.81096943938474 0.333333333333333 21.2 21 2 abnormal mammary gland morphology 0.432983099858682 0.759366911100108 0.81096943938474 0.333333333333333 21.2 21 2 abnormal prostate gland morphology 0.454518402565307 0.759366911100108 0.81096943938474 0.333333333333333 21.2 21 2 abnormal seizure response to electrical stimulation 0.454518402565307 0.759366911100108 0.81096943938474 0.333333333333333 21.2 21 2 abnormal iron level 0.432983099858682 0.759366911100108 0.81096943938474 0.333333333333333 21.2 21 2 abnormal thymus cortex morphology 0.432983099858682 0.759366911100108 0.81096943938474 0.333333333333333 21.2 21 2 altered righting response 0.454518402565307 0.759366911100108 0.81096943938474 0.333333333333333 21.2 21 2 increased circulating renin level 0.432983099858682 0.759366911100108 0.81096943938474 0.333333333333333 21.2 21 2 increased alcohol consumption 0.454518402565307 0.759366911100108 0.81096943938474 0.333333333333333 21.2 21 2 dilated ureter 0.454518402565307 0.759366911100108 0.81096943938474 0.333333333333333 21.2 21 2 decreased heart rate variability 0.432983099858682 0.759366911100108 0.81096943938474 0.333333333333333 21.2 21 2 abnormal zygomatic bone morphology 0.454518402565307 0.759366911100108 0.81096943938474 0.333333333333333 21.2 21 2 increased susceptibility to autoimmune disorder 0.432983099858682 0.759366911100108 0.81096943938474 0.333333333333333 21.2 21 2 immune system phenotype 0.454518402565307 0.759366911100108 0.81096943938474 0.333333333333333 21.2 21 2 abnormal Muller cell morphology 0.454518402565307 0.759366911100108 0.81096943938474 0.333333333333333 21.2 21 2 abnormal coronary vessel morphology 0.454518402565307 0.759366911100108 0.81096943938474 0.333333333333333 21.2 21 2 abnormal microglial cell activation 0.454518402565307 0.759366911100108 0.81096943938474 0.333333333333333 21.2 21 2 impaired leukocyte tethering or rolling 0.432983099858682 0.759366911100108 0.81096943938474 0.333333333333333 21.2 21 2 abnormal lymph node morphology 0.30893669778957 0.616358865454071 0.81096943938474 0.333333333333333 21.2 21 2 abnormal adrenal gland morphology 0.398224350376636 0.722525945705239 0.81096943938474 0.333333333333333 21.2 21 2 abnormal cardiac muscle contractility 0.398224350376636 0.722525945705239 0.81096943938474 0.333333333333333 21.2 21 2 dermatitis 0.315813818525156 0.616358865454071 0.79698720767121 0.327586206896552 21.2 21 2 increased susceptibility to injury 0.333516026767636 0.616589458628387 0.795373873242726 0.326923076923077 21.2 21 2 decreased urine osmolality 0.343108562149345 0.633382225117992 0.794419042662602 0.326530612244898 21.2 21 2 impaired ovarian folliculogenesis 0.375637977587174 0.686805931090111 0.790695203400121 0.325 21.2 21 2 head bobbing 0.375637977587174 0.686805931090111 0.790695203400121 0.325 21.2 21 2 abnormal skin pigmentation 0.375637977587174 0.686805931090111 0.790695203400121 0.325 21.2 21 2 abnormal T cell activation 0.304718346569553 0.611526330852571 0.789051346428396 0.324324324324324 21.2 21 2 increased insulin secretion 0.388039750154951 0.705333488133314 0.789051346428396 0.324324324324324 21.2 21 2 abnormal humerus morphology 0.388039750154951 0.705333488133314 0.789051346428396 0.324324324324324 21.2 21 2 abnormal humoral immune response 0.262524358441189 0.588630595019537 0.787798883973747 0.323809523809524 21.2 21 2 overexpanded pulmonary alveoli 0.401434772495626 0.726965177356664 0.787117397049895 0.323529411764706 21.2 21 2 decreased regulatory T cell number 0.401434772495626 0.726965177356664 0.787117397049895 0.323529411764706 21.2 21 2 increased susceptibility to weight gain 0.401434772495626 0.726965177356664 0.787117397049895 0.323529411764706 21.2 21 2 increased susceptibility to viral infection induced morbidity/mortality 0.401434772495626 0.726965177356664 0.787117397049895 0.323529411764706 21.2 21 2 abnormal body temperature homeostasis 0.416006772333942 0.745545278228156 0.784809134888458 0.32258064516129 21.2 21 2 decreased inflammatory response 0.308303676368877 0.616358865454071 0.782006245120999 0.321428571428571 21.2 21 2 increased circulating luteinizing hormone level 0.431998546198268 0.759366911100108 0.782006245120999 0.321428571428571 21.2 21 2 abnormal spleen germinal center morphology 0.431998546198268 0.759366911100108 0.782006245120999 0.321428571428571 21.2 21 2 abnormal feces composition 0.449740397036327 0.759366911100108 0.77853066180935 0.32 21.2 21 2 diaphragmatic hernia 0.449740397036327 0.759366911100108 0.77853066180935 0.32 21.2 21 2 decreased acute inflammation 0.449740397036327 0.759366911100108 0.77853066180935 0.32 21.2 21 2 decreased IgM level 0.303805874551766 0.610144526021958 0.777527400647225 0.319587628865979 21.2 21 2 increased susceptibility to bacterial infection induced morbidity/mortality 0.340465440908012 0.628736291209116 0.777179046077042 0.319444444444444 21.2 21 2 abnormal T-helper 1 physiology 0.389594869267533 0.707739016279186 0.776460101538581 0.319148936170213 21.2 21 2 short femur 0.325944052744097 0.616358865454071 0.774107192139979 0.318181818181818 21.2 21 2 increased T cell number 0.325944052744097 0.616358865454071 0.774107192139979 0.318181818181818 21.2 21 2 renal interstitial fibrosis 0.401939576000358 0.726965177356664 0.774107192139979 0.318181818181818 21.2 21 2 decreased macrophage cell number 0.401939576000358 0.726965177356664 0.774107192139979 0.318181818181818 21.2 21 2 abnormal long bone epiphysis morphology 0.469697853172104 0.759366911100108 0.774107192139979 0.318181818181818 21.2 21 2 abnormal retinal layer morphology 0.469697853172104 0.759366911100108 0.774107192139979 0.318181818181818 21.2 21 2 pulmonary vascular congestion 0.469697853172104 0.759366911100108 0.774107192139979 0.318181818181818 21.2 21 2 increased neutrophil cell number 0.27246249006282 0.588630595019537 0.771819190586856 0.317241379310345 21.2 21 2 impaired natural killer cell mediated cytotoxicity 0.389738136212075 0.707739016279186 0.768286837311859 0.315789473684211 21.2 21 2 decreased total retina thickness 0.429372681436261 0.757492585157943 0.768286837311859 0.315789473684211 21.2 21 2 irregular coat pigmentation 0.492556609219133 0.759366911100108 0.768286837311859 0.315789473684211 21.2 21 2 abnormal nail morphology 0.492556609219133 0.759366911100108 0.768286837311859 0.315789473684211 21.2 21 2 delayed sexual maturation 0.492556609219133 0.759366911100108 0.768286837311859 0.315789473684211 21.2 21 2 abnormal ear morphology 0.492556609219133 0.759366911100108 0.768286837311859 0.315789473684211 21.2 21 2 osteoarthritis 0.492556609219133 0.759366911100108 0.768286837311859 0.315789473684211 21.2 21 2 abnormal photoreceptor inner segment morphology 0.492556609219133 0.759366911100108 0.768286837311859 0.315789473684211 21.2 21 2 decreased eye pigmentation 0.492556609219133 0.759366911100108 0.768286837311859 0.315789473684211 21.2 21 2 eyelids fail to open 0.492556609219133 0.759366911100108 0.768286837311859 0.315789473684211 21.2 21 2 decreased liver glycogen level 0.492556609219133 0.759366911100108 0.768286837311859 0.315789473684211 21.2 21 2 absent mandible 0.51938540187012 0.783250189240329 0.760283849423194 0.3125 21.2 21 2 decreased mast cell number 0.51938540187012 0.783250189240329 0.760283849423194 0.3125 21.2 21 2 abnormal mouth morphology 0.51938540187012 0.783250189240329 0.760283849423194 0.3125 21.2 21 2 abnormal pituitary gland morphology 0.51938540187012 0.783250189240329 0.760283849423194 0.3125 21.2 21 2 abnormal olfaction 0.51938540187012 0.783250189240329 0.760283849423194 0.3125 21.2 21 2 white spotting 0.51938540187012 0.783250189240329 0.760283849423194 0.3125 21.2 21 2 abnormal epicardium morphology 0.51938540187012 0.783250189240329 0.760283849423194 0.3125 21.2 21 2 decreased cochlear coiling 0.51938540187012 0.783250189240329 0.760283849423194 0.3125 21.2 21 2 large intestinal inflammation 0.51938540187012 0.783250189240329 0.760283849423194 0.3125 21.2 21 2 bowed tibia 0.51938540187012 0.783250189240329 0.760283849423194 0.3125 21.2 21 2 abnormal epididymis epithelium morphology 0.51938540187012 0.783250189240329 0.760283849423194 0.3125 21.2 21 2 sepsis 0.51938540187012 0.783250189240329 0.760283849423194 0.3125 21.2 21 2 decreased circulating growth hormone level 0.51938540187012 0.783250189240329 0.760283849423194 0.3125 21.2 21 2 abnormal intestinal lipid absorption 0.51938540187012 0.783250189240329 0.760283849423194 0.3125 21.2 21 2 abnormal intestinal epithelium morphology 0.42625767448479 0.752263898744885 0.760283849423194 0.3125 21.2 21 2 abnormal cardiovascular system morphology 0.42625767448479 0.752263898744885 0.760283849423194 0.3125 21.2 21 2 abnormal ovarian follicle morphology 0.440017317746368 0.759366911100108 0.756904810092424 0.311111111111111 21.2 21 2 abnormal outer ear morphology 0.479970785822406 0.759366911100108 0.75504051253062 0.310344827586207 21.2 21 2 abnormal CD8-positive, alpha-beta T cell physiology 0.479970785822406 0.759366911100108 0.75504051253062 0.310344827586207 21.2 21 2 abnormal vibrissa morphology 0.454750234797387 0.759366911100108 0.753043050857259 0.30952380952381 21.2 21 2 increased circulating calcium level 0.435552873297918 0.759366911100108 0.751989843793122 0.309090909090909 21.2 21 2 abnormal skin condition 0.448836742833267 0.759366911100108 0.748587174816683 0.307692307692308 21.2 21 2 decreased body temperature 0.448836742833267 0.759366911100108 0.748587174816683 0.307692307692308 21.2 21 2 abnormal ureter morphology 0.500449571553073 0.763020722793913 0.748587174816683 0.307692307692308 21.2 21 2 decreased monocyte cell number 0.431347143134919 0.759366911100108 0.748587174816683 0.307692307692308 21.2 21 2 abnormal blood homeostasis 0.389789930573863 0.707739016279186 0.746945536275418 0.307017543859649 21.2 21 2 abnormal immune system physiology 0.387607277809006 0.705062598573968 0.745568678144035 0.306451612903226 21.2 21 2 decreased IgG level 0.398431151501212 0.722637615282002 0.745215160515707 0.306306306306306 21.2 21 2 head tilt 0.487749999124971 0.759366911100108 0.743388652769345 0.305555555555556 21.2 21 2 abnormal colon morphology 0.456356510812442 0.759366911100108 0.742243215708067 0.305084745762712 21.2 21 2 syndactyly 0.456356510812442 0.759366911100108 0.742243215708067 0.305084745762712 21.2 21 2 increased sensitivity to induced morbidity/mortality 0.374747841015439 0.685934697958723 0.74045035769911 0.304347826086957 21.2 21 2 abnormal inner ear morphology 0.477967457921564 0.759366911100108 0.74045035769911 0.304347826086957 21.2 21 2 abnormal postnatal growth 0.523493117001024 0.788966451705573 0.74045035769911 0.304347826086957 21.2 21 2 pancreas inflammation 0.523493117001024 0.788966451705573 0.74045035769911 0.304347826086957 21.2 21 2 abnormal digestive system physiology 0.499338867776203 0.76156065824237 0.729872495446266 0.3 21.2 21 2 abnormal female reproductive system morphology 0.511299544468267 0.778099071571416 0.729872495446266 0.3 21.2 21 2 increased metastatic potential 0.526921502064135 0.793412370692818 0.729872495446266 0.3 21.2 21 2 salivary gland inflammation 0.526921502064135 0.793412370692818 0.729872495446266 0.3 21.2 21 2 abnormal hair texture 0.549856091537424 0.824527790616349 0.729872495446266 0.3 21.2 21 2 abnormal heart right ventricle morphology 0.549856091537424 0.824527790616349 0.729872495446266 0.3 21.2 21 2 abnormal heart electrocardiography waveform feature 0.549856091537424 0.824527790616349 0.729872495446266 0.3 21.2 21 2 abnormal femur morphology 0.494319788309308 0.759366911100108 0.72624128900126 0.298507462686567 21.2 21 2 cryptorchism 0.549628326740226 0.824527790616349 0.720861723897547 0.296296296296296 21.2 21 2 decreased bone ossification 0.549628326740226 0.824527790616349 0.720861723897547 0.296296296296296 21.2 21 2 abnormal photoreceptor outer segment morphology 0.532659394660286 0.801809527514348 0.718813821272838 0.295454545454545 21.2 21 2 decreased susceptibility to injury 0.52539315863528 0.791590237495614 0.715561270045359 0.294117647058824 21.2 21 2 abnormal oocyte morphology 0.550171240837735 0.824527790616349 0.715561270045359 0.294117647058824 21.2 21 2 decreased pancreatic beta cell number 0.550171240837735 0.824527790616349 0.715561270045359 0.294117647058824 21.2 21 2 enlarged sebaceous gland 0.580681413049152 0.85167748523571 0.715561270045359 0.294117647058824 21.2 21 2 nephrocalcinosis 0.580681413049152 0.85167748523571 0.715561270045359 0.294117647058824 21.2 21 2 abnormal tarsal bone morphology 0.580681413049152 0.85167748523571 0.715561270045359 0.294117647058824 21.2 21 2 abnormal hair shaft morphology 0.552188758744468 0.824527790616349 0.709598259461647 0.291666666666667 21.2 21 2 curly vibrissae 0.57507437384636 0.84420035700373 0.709598259461647 0.291666666666667 21.2 21 2 hemolytic anemia 0.57507437384636 0.84420035700373 0.709598259461647 0.291666666666667 21.2 21 2 decreased fatty acid level 0.57507437384636 0.84420035700373 0.709598259461647 0.291666666666667 21.2 21 2 increased eosinophil cell number 0.554662278426928 0.824527790616349 0.706328221399612 0.290322580645161 21.2 21 2 abnormal intestine physiology 0.572295709681032 0.840865669126737 0.706328221399612 0.290322580645161 21.2 21 2 abnormal dendritic cell physiology 0.55088516611419 0.824527790616349 0.704861288437204 0.289719626168224 21.2 21 2 abnormal leukocyte migration 0.570164526019767 0.83798183661694 0.70180047639064 0.288461538461538 21.2 21 2 small ears 0.604000812362652 0.87785686284084 0.695116662329777 0.285714285714286 21.2 21 2 increased vasoconstriction 0.604000812362652 0.87785686284084 0.695116662329777 0.285714285714286 21.2 21 2 abnormal stapes morphology 0.604000812362652 0.87785686284084 0.695116662329777 0.285714285714286 21.2 21 2 abnormal clavicle morphology 0.604000812362652 0.87785686284084 0.695116662329777 0.285714285714286 21.2 21 2 increased liver weight 0.599073014258999 0.871713438414309 0.691167135839267 0.284090909090909 21.2 21 2 abnormal crypts of Lieberkuhn morphology 0.615637405831826 0.890552119308062 0.684255464480874 0.28125 21.2 21 2 ruffled hair 0.62381536482804 0.890552119308062 0.681214329083182 0.28 21.2 21 2 impaired conditioned place preference behavior 0.62381536482804 0.890552119308062 0.681214329083182 0.28 21.2 21 2 abnormal male reproductive system morphology 0.626615543587167 0.890552119308062 0.678951158554666 0.27906976744186 21.2 21 2 abnormal cochlea morphology 0.636794401194465 0.890552119308062 0.67580786615395 0.277777777777778 21.2 21 2 abnormal inflammatory response 0.64304820692686 0.890552119308062 0.67580786615395 0.277777777777778 21.2 21 2 acidosis 0.637488456583948 0.890552119308062 0.67580786615395 0.277777777777778 21.2 21 2 decreased activity of thyroid 0.637488456583948 0.890552119308062 0.67580786615395 0.277777777777778 21.2 21 2 abnormal metanephric mesenchyme morphology 0.637488456583948 0.890552119308062 0.67580786615395 0.277777777777778 21.2 21 2 abnormal parietal bone morphology 0.641140983008286 0.890552119308062 0.67114712224944 0.275862068965517 21.2 21 2 abnormal circulating glucose level 0.641140983008286 0.890552119308062 0.67114712224944 0.275862068965517 21.2 21 2 focal hair loss 0.641140983008286 0.890552119308062 0.67114712224944 0.275862068965517 21.2 21 2 stomach inflammation 0.641140983008286 0.890552119308062 0.67114712224944 0.275862068965517 21.2 21 2 increased susceptibility to induced arthritis 0.641140983008286 0.890552119308062 0.67114712224944 0.275862068965517 21.2 21 2 increased retinal apoptosis 0.641140983008286 0.890552119308062 0.67114712224944 0.275862068965517 21.2 21 2 intestinal ulcer 0.654364422059107 0.894357966962654 0.663520450405696 0.272727272727273 21.2 21 2 decreased airway responsiveness 0.654364422059107 0.894357966962654 0.663520450405696 0.272727272727273 21.2 21 2 abnormal retinal outer plexiform layer morphology 0.654364422059107 0.894357966962654 0.663520450405696 0.272727272727273 21.2 21 2 abnormal circulating lipid level 0.654364422059107 0.894357966962654 0.663520450405696 0.272727272727273 21.2 21 2 abnormal blood-brain barrier function 0.654364422059107 0.894357966962654 0.663520450405696 0.272727272727273 21.2 21 2 abnormal T cell subpopulation ratio 0.656591975242343 0.896909686114952 0.663520450405696 0.272727272727273 21.2 21 2 decreased sensitivity to xenobiotic induced morbidity/mortality 0.656591975242343 0.896909686114952 0.663520450405696 0.272727272727273 21.2 21 2 hypertension 0.661849099434747 0.903480090628142 0.663520450405696 0.272727272727273 21.2 21 2 pulmonary edema 0.669265920245133 0.909726216726649 0.655013777964598 0.269230769230769 21.2 21 2 increased width of hypertrophic chondrocyte zone 0.694903439628001 0.941488184136521 0.644005143040823 0.264705882352941 21.2 21 2 abnormal triglyceride level 0.689249830642811 0.934082786011436 0.640239031093216 0.263157894736842 21.2 21 2 small superior vagus ganglion 0.689249830642811 0.934082786011436 0.640239031093216 0.263157894736842 21.2 21 2 decreased germ cell number 0.689249830642811 0.934082786011436 0.640239031093216 0.263157894736842 21.2 21 2 decreased susceptibility to induced arthritis 0.725890702294814 0.970793603916721 0.640239031093216 0.263157894736842 21.2 21 2 abnormal blood vessel physiology 0.700554294432549 0.948369418993723 0.634671735170666 0.260869565217391 21.2 21 2 abnormal regulatory T cell physiology 0.700554294432549 0.948369418993723 0.634671735170666 0.260869565217391 21.2 21 2 abnormal lens development 0.700554294432549 0.948369418993723 0.634671735170666 0.260869565217391 21.2 21 2 autoimmune response 0.72106825450976 0.970793603916721 0.627847307910766 0.258064516129032 21.2 21 2 impaired behavioral response to xenobiotic 0.730407785095365 0.970793603916721 0.625604996096799 0.257142857142857 21.2 21 2 abnormal intestinal mucosa morphology 0.747550413982452 0.970793603916721 0.622371895341777 0.255813953488372 21.2 21 2 waved hair 0.735714410344606 0.970793603916721 0.608227079538555 0.25 21.2 21 2 abnormal fibula morphology 0.735714410344606 0.970793603916721 0.608227079538555 0.25 21.2 21 2 abnormal incus morphology 0.735714410344606 0.970793603916721 0.608227079538555 0.25 21.2 21 2 abnormal stria vascularis morphology 0.749292024310131 0.972535304185469 0.608227079538555 0.25 21.2 21 2 short radius 0.763023560809812 0.990099690930834 0.608227079538555 0.25 21.2 21 2 increased susceptibility to weight loss 0.769668290703541 0.998461472294684 0.608227079538555 0.25 21.2 21 2 increased percent body fat/body weight 0.788390317582732 1 0.608227079538555 0.25 21.2 21 2 small lymph nodes 0.742380934627945 0.970793603916721 0.608227079538555 0.25 21.2 21 2 short humerus 0.797512064941053 1 0.593392272720541 0.24390243902439 21.2 21 2 abnormal stomach mucosa morphology 0.779822693512126 1 0.583897996357013 0.24 21.2 21 2 abnormal thrombosis 0.850235058342175 1 0.572449016036287 0.235294117647059 21.2 21 2 small seminal vesicle 0.812989725492224 1 0.561440381112512 0.230769230769231 21.2 21 2 decreased IgA level 0.868788480570008 1 0.561440381112512 0.230769230769231 21.2 21 2 abnormal tectorial membrane morphology 0.812989725492224 1 0.561440381112512 0.230769230769231 21.2 21 2 abnormal kidney physiology 0.867252873030295 1 0.557541489577009 0.229166666666667 21.2 21 2 abnormal mesenteric lymph node morphology 0.812907406083043 1 0.552933708671414 0.227272727272727 21.2 21 2 impaired humoral immune response 0.812907406083043 1 0.552933708671414 0.227272727272727 21.2 21 2 absent mature ovarian follicles 0.841688263091743 1 0.549366394421921 0.225806451612903 21.2 21 2 decreased susceptibility to bacterial infection induced morbidity/mortality 0.841688263091743 1 0.549366394421921 0.225806451612903 21.2 21 2 abnormal diaphragm morphology 0.865621652951424 1 0.532198694596236 0.21875 21.2 21 2 abnormal ulna morphology 0.844116603763735 1 0.528893112642222 0.217391304347826 21.2 21 2 increased systemic arterial blood pressure 0.914559669778656 1 0.517640067692387 0.212765957446809 21.2 21 2 diarrhea 0.886495495628523 1 0.516071461426653 0.212121212121212 21.2 21 2 abnormal middle ear ossicle morphology 0.886495495628523 1 0.516071461426653 0.212121212121212 21.2 21 2 increased susceptibility to parasitic infection 0.966849149945593 1 0.513613978277002 0.211111111111111 21.2 21 2 abnormal malleus morphology 0.870889148273154 1 0.506855899615462 0.208333333333333 21.2 21 2 abnormal cellular extravasation 0.870889148273154 1 0.506855899615462 0.208333333333333 21.2 21 2 decreased cytotoxic T cell cytolysis 0.904574265354559 1 0.500892889031751 0.205882352941176 21.2 21 2 abnormal estrous cycle 0.90792691124123 1 0.486581663630844 0.2 21.2 21 2 abnormal gametogenesis 0.966463577607547 1 0.442346966937131 0.181818181818182 21.2 21 2 abnormal leukocyte adhesion 0.962364471769957 1 0.436675851976398 0.179487179487179 21.2 21 2 short ulna 0.974725605518046 1 0.415374590904379 0.170731707317073 21.2 21 2 ischuria 2.45899456357862e-05 0.000933854805633865 7.34949544671425 1 22.1 22 1 abnormal lymphatic vessel endothelial cell morphology 2.45899456357862e-05 0.000933854805633865 7.34949544671425 1 22.1 22 1 enlarged lymphatic vessel 0.000132830219026837 0.00376649732309574 6.12457953892854 0.833333333333333 22.1 22 1 abnormal conotruncal ridge morphology 0.000418700956994003 0.00929927348680877 5.24963960479589 0.714285714285714 22.1 22 1 vascular smooth muscle hypoplasia 5.70968063741001e-06 0.000288952353033428 4.7246756443163 0.642857142857143 22.1 22 1 abnormal hepatobiliary system morphology 0.00100592565802624 0.0180530897618375 4.59343465419641 0.625 22.1 22 1 increased aorta wall thickness 0.00100592565802624 0.0180530897618375 4.59343465419641 0.625 22.1 22 1 abnormal vascular branching morphogenesis 1.77659096782597e-07 1.40294286744987e-05 4.34288367305842 0.590909090909091 22.1 22 1 decreased synaptic depression 0.000160718997463397 0.00432203790475893 4.28720567724998 0.583333333333333 22.1 22 1 abnormal vascular endothelial cell development 0.000160718997463397 0.00432203790475893 4.28720567724998 0.583333333333333 22.1 22 1 abnormal incisor color 0.00203985389976587 0.0307523428828339 4.08305302595236 0.555555555555556 22.1 22 1 iris coloboma 0.00203985389976587 0.0307523428828339 4.08305302595236 0.555555555555556 22.1 22 1 abnormal sphenoid bone morphology 0.000793549085431081 0.0154215105469517 4.00881569820777 0.545454545454545 22.1 22 1 abnormal lymph circulation 0.000793549085431081 0.0154215105469517 4.00881569820777 0.545454545454545 22.1 22 1 abnormal dorsal-ventral polarity of the somites 0.000793549085431081 0.0154215105469517 4.00881569820777 0.545454545454545 22.1 22 1 abnormal embryonic hematopoiesis 1.97189218599308e-08 1.88656992794531e-06 3.90441945606694 0.53125 22.1 22 1 abnormal liver development 1.47794865354229e-08 1.44172442183783e-06 3.77974051545304 0.514285714285714 22.1 22 1 pulmonary edema 2.32929671756407e-06 0.000131684672385014 3.67474772335713 0.5 22.1 22 1 abnormal vasodilation 5.75000662317777e-06 0.000288952353033428 3.67474772335713 0.5 22.1 22 1 amyloid beta deposits 0.000559699655209189 0.0119506686037155 3.67474772335713 0.5 22.1 22 1 delayed somite formation 0.00142637917339876 0.0234199220714813 3.67474772335713 0.5 22.1 22 1 hematuria 0.00142637917339876 0.0234199220714813 3.67474772335713 0.5 22.1 22 1 decreased mammary gland epithelial cell proliferation 0.00142637917339876 0.0234199220714813 3.67474772335713 0.5 22.1 22 1 abnormal vascular regression 3.53784257366984e-05 0.00126624221611564 3.67474772335712 0.5 22.1 22 1 vasculature congestion 0.000221555365195593 0.005566858292162 3.67474772335712 0.5 22.1 22 1 abnormal pulmonary alveolus wall morphology 0.000221555365195593 0.005566858292162 3.67474772335712 0.5 22.1 22 1 lymphedema 0.00367824375453562 0.0490596854659912 3.67474772335712 0.5 22.1 22 1 abnormal gonadal fat pad morphology 0.00367824375453562 0.0490596854659912 3.67474772335712 0.5 22.1 22 1 abnormal developmental vascular remodeling 0.00367824375453562 0.0490596854659912 3.67474772335712 0.5 22.1 22 1 thick aortic valve cusps 0.00367824375453562 0.0490596854659912 3.67474772335712 0.5 22.1 22 1 fusion of atlas and odontoid process 0.00367824375453562 0.0490596854659912 3.67474772335712 0.5 22.1 22 1 lethality during fetal growth through weaning, complete penetrance 0.00367824375453562 0.0490596854659912 3.67474772335712 0.5 22.1 22 1 abnormal vascular development 3.1575729946892e-13 7.4804407850375e-11 3.56339173174024 0.484848484848485 22.1 22 1 enlarged pericardium 2.70822457112366e-07 2.01095779721496e-05 3.56339173174024 0.484848484848485 22.1 22 1 pale yolk sac 4.64645445839398e-16 1.77816237927001e-13 3.5419255164888 0.481927710843373 22.1 22 1 abnormal hematopoietic stem cell physiology 2.43288878162755e-05 0.000933854805633865 3.51497608321116 0.478260869565217 22.1 22 1 absent incisors 0.00094111951107948 0.0170878451373008 3.42976454179998 0.466666666666667 22.1 22 1 delayed intramembranous bone ossification 0.00094111951107948 0.0170878451373008 3.42976454179998 0.466666666666667 22.1 22 1 absent common myeloid progenitor cells 0.0023814465213047 0.035052356341689 3.39207482156042 0.461538461538462 22.1 22 1 empty decidua capsularis 0.0023814465213047 0.035052356341689 3.39207482156042 0.461538461538462 22.1 22 1 abnormal germ layer development 9.8651388214255e-05 0.00297448882646011 3.34067974850648 0.454545454545455 22.1 22 1 premature suture closure 0.00608215597878939 0.0694007476937551 3.34067974850648 0.454545454545455 22.1 22 1 abnormal proximal-distal axis patterning 0.00608215597878939 0.0694007476937551 3.34067974850648 0.454545454545455 22.1 22 1 pulmonary hypertension 0.00608215597878939 0.0694007476937551 3.34067974850648 0.454545454545455 22.1 22 1 pathological neovascularization 0.00608215597878939 0.0694007476937551 3.34067974850648 0.454545454545455 22.1 22 1 abnormal Bruch membrane morphology 0.00608215597878939 0.0694007476937551 3.34067974850648 0.454545454545455 22.1 22 1 abnormal aorta smooth muscle morphology 0.00608215597878939 0.0694007476937551 3.34067974850648 0.454545454545455 22.1 22 1 chylous ascites 0.00608215597878939 0.0694007476937551 3.34067974850648 0.454545454545455 22.1 22 1 abnormal aorta morphology 1.80894865705527e-06 0.00010894106568107 3.34067974850648 0.454545454545455 22.1 22 1 trabecula carnea hypoplasia 5.57010098956279e-08 4.77780214190947e-06 3.26644242076189 0.444444444444444 22.1 22 1 abnormal bile duct morphology 0.000603594682465677 0.0126703947057669 3.26644242076189 0.444444444444444 22.1 22 1 increased circulating renin level 0.000603594682465677 0.0126703947057669 3.26644242076189 0.444444444444444 22.1 22 1 small pancreas 0.00150078051343361 0.0243204659750236 3.21540425793748 0.4375 22.1 22 1 abnormal pulmonary artery morphology 0.000155822542366547 0.00423615928018345 3.19543280291924 0.434782608695652 22.1 22 1 abnormal pancreas development 0.00374775667087633 0.0492588296690079 3.14978376287754 0.428571428571429 22.1 22 1 testis degeneration 0.00374775667087633 0.0492588296690079 3.14978376287754 0.428571428571429 22.1 22 1 decreased tumor incidence 0.000933536904748391 0.0170748018423649 3.09452439861653 0.421052631578947 22.1 22 1 thin interventricular septum 0.000933536904748391 0.0170748018423649 3.09452439861653 0.421052631578947 22.1 22 1 decreased circulating total protein level 2.34282511337857e-08 2.15843609982563e-06 3.07342536862596 0.418181818181818 22.1 22 1 overriding aortic valve 2.05461275794932e-07 1.57256899550736e-05 3.06228976946427 0.416666666666667 22.1 22 1 abnormal supraoccipital bone morphology 0.0094077108397827 0.092993686344218 3.06228976946427 0.416666666666667 22.1 22 1 abnormal rostral-caudal body axis extension 0.0094077108397827 0.092993686344218 3.06228976946427 0.416666666666667 22.1 22 1 hemoperitoneum 0.0094077108397827 0.092993686344218 3.06228976946427 0.416666666666667 22.1 22 1 abnormal aorta elastic tissue morphology 0.0094077108397827 0.092993686344218 3.06228976946427 0.416666666666667 22.1 22 1 heart right ventricle hypertrophy 6.82792927884408e-06 0.000329795613225721 3.06228976946427 0.416666666666667 22.1 22 1 hemopericardium 1.8175092364882e-06 0.00010894106568107 3.04735177058884 0.414634146341463 22.1 22 1 abnormal bone marrow cavity morphology 0.00228912545821482 0.0340970034569423 3.02626283099999 0.411764705882353 22.1 22 1 increased trabecular bone mass 0.00228912545821482 0.0340970034569423 3.02626283099999 0.411764705882353 22.1 22 1 increased hepatocyte apoptosis 4.31194685487178e-06 0.000221153975288527 3.01517761916482 0.41025641025641 22.1 22 1 increased myocardial infarction size 0.000576751158335371 0.0122621239859764 3.00661177365583 0.409090909090909 22.1 22 1 abnormal bone trabecula morphology 0.000148417017239732 0.00405700363059159 2.9942388856984 0.407407407407407 22.1 22 1 abnormal lymphatic vessel morphology 3.87366315166817e-05 0.00136677121840774 2.98573252522766 0.40625 22.1 22 1 increased fibroblast apoptosis 3.87366315166817e-05 0.00136677121840774 2.98573252522766 0.40625 22.1 22 1 abnormal vitelline vasculature morphology 2.02681513408823e-14 6.72227019472597e-12 2.9397981786857 0.4 22.1 22 1 thick pulmonary interalveolar septum 2.41399360171501e-05 0.000933854805633865 2.9397981786857 0.4 22.1 22 1 abnormal artery morphology 2.41399360171501e-05 0.000933854805633865 2.9397981786857 0.4 22.1 22 1 abnormal lactation 9.20214267858541e-05 0.00282596665592361 2.9397981786857 0.4 22.1 22 1 abnormal circulating enzyme level 0.00139346595004072 0.0231083103381753 2.9397981786857 0.4 22.1 22 1 abnormal physiological neovascularization 0.00139346595004072 0.0231083103381753 2.9397981786857 0.4 22.1 22 1 abnormal placenta size 0.00561884811074089 0.0665565936927046 2.9397981786857 0.4 22.1 22 1 abnormal aorta wall morphology 0.00561884811074089 0.0665565936927046 2.9397981786857 0.4 22.1 22 1 abnormal coronary vessel morphology 0.00561884811074089 0.0665565936927046 2.9397981786857 0.4 22.1 22 1 kidney failure 3.98640604860362e-06 0.000206587188456282 2.90561447893354 0.395348837209302 22.1 22 1 incomplete somite formation 1.50073175430088e-05 0.000617036403111311 2.90111662370299 0.394736842105263 22.1 22 1 abnormal angiogenesis 2.2268350785729e-09 2.57639639904656e-07 2.88020767506369 0.391891891891892 22.1 22 1 abnormal cell differentiation 9.3134571196285e-06 0.000426537696294606 2.86809578408361 0.390243902439024 22.1 22 1 ventricular septal defect 8.12777985493068e-16 2.88826462702001e-13 2.8641416079107 0.389705882352941 22.1 22 1 thin ventricular wall 6.51407894317285e-11 9.25929792636712e-09 2.85813711816665 0.388888888888889 22.1 22 1 abnormal mitral valve morphology 0.00336173595187336 0.0456957277611201 2.85813711816665 0.388888888888889 22.1 22 1 absent allantois 0.00336173595187336 0.0456957277611201 2.85813711816665 0.388888888888889 22.1 22 1 absent vitelline blood vessels 2.58546307034795e-07 1.94889072348198e-05 2.83664736539848 0.385964912280702 22.1 22 1 liver hypoplasia 9.59571741628815e-07 6.00665690188795e-05 2.82672901796702 0.384615384615385 22.1 22 1 increased cochlear inner hair cell number 0.0137991260388315 0.115303738850336 2.82672901796702 0.384615384615385 22.1 22 1 abnormal aorta tunica media morphology 0.0137991260388315 0.115303738850336 2.82672901796702 0.384615384615385 22.1 22 1 absent hypoglossal nerve 0.0137991260388315 0.115303738850336 2.82672901796702 0.384615384615385 22.1 22 1 lung hemorrhage 8.20842912126513e-05 0.00255230842989338 2.81010120021427 0.382352941176471 22.1 22 1 vascular ring 0.00201642044930248 0.0305844260221946 2.79980778922448 0.380952380952381 22.1 22 1 abnormal interventricular septum morphology 2.21177338444001e-06 0.000128975117329701 2.79280826975142 0.38 22.1 22 1 pale liver 1.05229659538748e-08 1.07862216332649e-06 2.78089016902701 0.378378378378378 22.1 22 1 abnormal heart atrium morphology 0.000190882316540898 0.00502454775021676 2.75606079251784 0.375 22.1 22 1 abnormal olfaction 0.00808968866912527 0.0845508427077694 2.75606079251784 0.375 22.1 22 1 large intestinal inflammation 0.00808968866912527 0.0845508427077694 2.75606079251784 0.375 22.1 22 1 blepharitis 0.00808968866912527 0.0845508427077694 2.75606079251784 0.375 22.1 22 1 kidney degeneration 0.00808968866912527 0.0845508427077694 2.75606079251784 0.375 22.1 22 1 lethality throughout fetal growth and development, complete penetrance 1.77109917531131e-19 8.81121839717375e-17 2.74639040377217 0.373684210526316 22.1 22 1 small liver 9.22747382350146e-09 9.76737920679144e-07 2.73250471736812 0.371794871794872 22.1 22 1 abnormal embryonic epiblast morphology 0.000116324137464539 0.00343917267222044 2.72981259449386 0.371428571428571 22.1 22 1 abnormal cell adhesion 1.92841523389177e-06 0.000114212687959661 2.72203535063491 0.37037037037037 22.1 22 1 abnormal triglyceride level 0.0047781853960296 0.05972731745037 2.70770884878946 0.368421052631579 22.1 22 1 osteoarthritis 0.0047781853960296 0.05972731745037 2.70770884878946 0.368421052631579 22.1 22 1 intracranial hemorrhage 7.32087572789858e-07 4.85618089950606e-05 2.69481499712856 0.366666666666667 22.1 22 1 hemorrhage 1.42806716797785e-22 1.42092683213797e-19 2.68960258901032 0.365957446808511 22.1 22 1 abnormal mammary gland development 4.33130164144559e-05 0.00148608452870288 2.68883979757838 0.365853658536585 22.1 22 1 increased tumor growth/size 4.33130164144559e-05 0.00148608452870288 2.68883979757838 0.365853658536585 22.1 22 1 abnormal definitive hematopoiesis 8.44017794755245e-10 9.99759173549368e-08 2.68691231385252 0.365591397849462 22.1 22 1 double outlet right ventricle 5.5514470076768e-11 8.1230731950565e-09 2.67878806001734 0.364485981308411 22.1 22 1 embryonic lethality, incomplete penetrance 2.64630707880014e-05 0.000989878023836894 2.67254379880518 0.363636363636364 22.1 22 1 abnormal cochlear sensory epithelium morphology 0.00283908861556939 0.039794264493973 2.67254379880518 0.363636363636364 22.1 22 1 abnormal basement membrane morphology 0.00283908861556939 0.039794264493973 2.67254379880518 0.363636363636364 22.1 22 1 abnormal somite shape 0.00101605329312854 0.0180530897618375 2.62481980239795 0.357142857142857 22.1 22 1 corneal vascularization 0.00101605329312854 0.0180530897618375 2.62481980239795 0.357142857142857 22.1 22 1 abnormal kidney blood vessel morphology 0.0193832201321399 0.140416180205777 2.62481980239795 0.357142857142857 22.1 22 1 translucent skin 0.0193832201321399 0.140416180205777 2.62481980239795 0.357142857142857 22.1 22 1 irregularly shaped pupil 0.0193832201321399 0.140416180205777 2.62481980239795 0.357142857142857 22.1 22 1 absent visceral yolk sac blood islands 0.0193832201321399 0.140416180205777 2.62481980239795 0.357142857142857 22.1 22 1 abnormal fluid regulation 0.0193832201321399 0.140416180205777 2.62481980239795 0.357142857142857 22.1 22 1 decreased vascular permeability 0.0193832201321399 0.140416180205777 2.62481980239795 0.357142857142857 22.1 22 1 abnormal vascular endothelial cell migration 0.0193832201321399 0.140416180205777 2.62481980239795 0.357142857142857 22.1 22 1 increased stomach tumor incidence 0.0193832201321399 0.140416180205777 2.62481980239795 0.357142857142857 22.1 22 1 pulmonary alveolar hemorrhage 0.0193832201321399 0.140416180205777 2.62481980239795 0.357142857142857 22.1 22 1 abnormal vitelline vein topology 0.0193832201321399 0.140416180205777 2.62481980239795 0.357142857142857 22.1 22 1 decreased hemoglobin content 3.91983204427903e-13 8.86416564558553e-11 2.60620405911853 0.354609929078014 22.1 22 1 pericardial edema 5.26396181926881e-07 3.6372513959531e-05 2.59393956942856 0.352941176470588 22.1 22 1 abnormal thrombosis 1.35944131251572e-05 0.000563601710813808 2.59393956942856 0.352941176470588 22.1 22 1 short maxilla 0.000368529215793361 0.00833378567532715 2.59393956942856 0.352941176470588 22.1 22 1 overexpanded pulmonary alveoli 0.000368529215793361 0.00833378567532715 2.59393956942856 0.352941176470588 22.1 22 1 abnormal ectoplacental cone morphology 0.0112536322387128 0.104628740559253 2.59393956942856 0.352941176470588 22.1 22 1 delayed heart development 0.0112536322387128 0.104628740559253 2.59393956942856 0.352941176470588 22.1 22 1 abnormal cell cytoskeleton morphology 0.0112536322387128 0.104628740559253 2.59393956942856 0.352941176470588 22.1 22 1 abnormal lung development 2.09042006819787e-08 1.96223393194046e-06 2.59393956942856 0.352941176470588 22.1 22 1 abnormal erythropoiesis 5.19895621646586e-10 6.30933020428561e-08 2.58982220503264 0.352380952380952 22.1 22 1 abnormal apoptosis 8.30690584333346e-06 0.000389876005382867 2.58593358310316 0.351851851851852 22.1 22 1 abnormal osteoblast physiology 8.30690584333346e-06 0.000389876005382867 2.58593358310316 0.351851851851852 22.1 22 1 abnormal branching of the mammary ductal tree 0.000222793021794584 0.00556982554486459 2.58225515695366 0.351351351351351 22.1 22 1 abnormal Peyer's patch T cell area morphology 0.00660072663617744 0.0720908997031511 2.57232340634999 0.35 22.1 22 1 abnormal heart right ventricle morphology 0.00660072663617744 0.0720908997031511 2.57232340634999 0.35 22.1 22 1 dilated vasculature 0.00660072663617744 0.0720908997031511 2.57232340634999 0.35 22.1 22 1 abnormal sperm mitochondrial sheath morphology 0.00660072663617744 0.0720908997031511 2.57232340634999 0.35 22.1 22 1 abnormal heart development 6.54902155098652e-14 1.8569193544789e-11 2.55836866816002 0.348101265822785 22.1 22 1 abnormal blood vessel physiology 0.003901350210143 0.0505448367069308 2.55634624233539 0.347826086956522 22.1 22 1 conjunctivitis 0.003901350210143 0.0505448367069308 2.55634624233539 0.347826086956522 22.1 22 1 abnormal B cell morphology 0.003901350210143 0.0505448367069308 2.55634624233539 0.347826086956522 22.1 22 1 perimembraneous ventricular septal defect 7.15749802761527e-07 4.81196657937648e-05 2.55634624233539 0.347826086956522 22.1 22 1 distended pericardium 1.84728406478644e-05 0.0007471738392124 2.54405611617032 0.346153846153846 22.1 22 1 thick skin 0.00231966534388001 0.0344487614501584 2.54405611617032 0.346153846153846 22.1 22 1 abnormal embryonic erythropoiesis 0.00138581944236101 0.0231083103381753 2.53430877472905 0.344827586206897 22.1 22 1 abnormal spongiotrophoblast layer morphology 0.000831155816302233 0.0160271325042776 2.52638905980802 0.34375 22.1 22 1 embryonic lethality between somite formation and embryo turning, complete penetrance 9.65894577188013e-07 6.00665690188795e-05 2.51982701030203 0.342857142857143 22.1 22 1 abnormal dermal layer morphology 0.000500114474051877 0.0107708636727623 2.51982701030203 0.342857142857143 22.1 22 1 decreased glycogen level 0.000500114474051877 0.0107708636727623 2.51982701030203 0.342857142857143 22.1 22 1 increased red blood cell distribution width 0.000500114474051877 0.0107708636727623 2.51982701030203 0.342857142857143 22.1 22 1 abnormal frontal bone morphology 0.000301751051423551 0.00711792662905732 2.51430107387593 0.342105263157895 22.1 22 1 abnormal liver physiology 7.39258413328574e-09 7.99524044849925e-07 2.49882845188285 0.34 22.1 22 1 short stride length 4.08224532432431e-05 0.00142022171248346 2.49882845188285 0.34 22.1 22 1 increased granulocyte number 7.92887726248962e-07 5.19028478695867e-05 2.48293765091698 0.337837837837838 22.1 22 1 edema 6.71850218705933e-14 1.8569193544789e-11 2.47831823203155 0.337209302325581 22.1 22 1 distended abdomen 5.44364733022865e-05 0.00174723519147662 2.44983181557142 0.333333333333333 22.1 22 1 small lung 5.44364733022865e-05 0.00174723519147662 2.44983181557142 0.333333333333333 22.1 22 1 increased vascular permeability 0.000403358803361467 0.00903923444469955 2.44983181557142 0.333333333333333 22.1 22 1 increased circulating total protein level 0.00524570209078037 0.0640809665998269 2.44983181557142 0.333333333333333 22.1 22 1 abnormal truncus arteriosus septation 0.00524570209078037 0.0640809665998269 2.44983181557142 0.333333333333333 22.1 22 1 abnormal lung saccule morphology 0.00524570209078037 0.0640809665998269 2.44983181557142 0.333333333333333 22.1 22 1 abnormal incisor morphology 1.23154416888907e-05 0.00051923154578162 2.44983181557142 0.333333333333333 22.1 22 1 abnormal neuronal precursor proliferation 3.31294052076166e-05 0.00120305686794082 2.44983181557142 0.333333333333333 22.1 22 1 abnormal myocardial trabeculae morphology 0.00014763222584712 0.00405700363059159 2.44983181557142 0.333333333333333 22.1 22 1 abnormal cartilage morphology 0.000243768072173641 0.00591583492226276 2.44983181557142 0.333333333333333 22.1 22 1 skin edema 0.000243768072173641 0.00591583492226276 2.44983181557142 0.333333333333333 22.1 22 1 myeloid hyperplasia 0.00111301822089444 0.0193610687026219 2.44983181557142 0.333333333333333 22.1 22 1 abnormal brain vasculature morphology 0.00185786883214779 0.0284396844305701 2.44983181557142 0.333333333333333 22.1 22 1 abnormal type II pneumocyte morphology 0.00311396606440638 0.0429615744846911 2.44983181557142 0.333333333333333 22.1 22 1 abnormal tumor vascularization 0.00889287972961494 0.091716753563063 2.44983181557142 0.333333333333333 22.1 22 1 lowered ear position 0.0151995803821325 0.118152988126733 2.44983181557142 0.333333333333333 22.1 22 1 abnormal megakaryocyte differentiation 0.0151995803821325 0.118152988126733 2.44983181557142 0.333333333333333 22.1 22 1 thick dermal layer 0.0151995803821325 0.118152988126733 2.44983181557142 0.333333333333333 22.1 22 1 eye inflammation 0.0151995803821325 0.118152988126733 2.44983181557142 0.333333333333333 22.1 22 1 abnormal thyroid cartilage morphology 0.0151995803821325 0.118152988126733 2.44983181557142 0.333333333333333 22.1 22 1 abnormal thymus medulla morphology 0.0151995803821325 0.118152988126733 2.44983181557142 0.333333333333333 22.1 22 1 abnormal redox activity 0.0151995803821325 0.118152988126733 2.44983181557142 0.333333333333333 22.1 22 1 darkened coat color 0.0151995803821325 0.118152988126733 2.44983181557142 0.333333333333333 22.1 22 1 abnormal glycogen homeostasis 0.0151995803821325 0.118152988126733 2.44983181557142 0.333333333333333 22.1 22 1 abnormal pregnancy 0.0151995803821325 0.118152988126733 2.44983181557142 0.333333333333333 22.1 22 1 increased gastrointestinal tumor incidence 0.0151995803821325 0.118152988126733 2.44983181557142 0.333333333333333 22.1 22 1 abnormal macrophage chemotaxis 0.0151995803821325 0.118152988126733 2.44983181557142 0.333333333333333 22.1 22 1 increased effector memory CD8-positive, alpha-beta T cell number 0.0151995803821325 0.118152988126733 2.44983181557142 0.333333333333333 22.1 22 1 decreased fluid intake 0.0151995803821325 0.118152988126733 2.44983181557142 0.333333333333333 22.1 22 1 decreased salivation 0.0262654061428393 0.169262170415318 2.44983181557142 0.333333333333333 22.1 22 1 abnormal cricoid cartilage morphology 0.0262654061428393 0.169262170415318 2.44983181557142 0.333333333333333 22.1 22 1 abnormal pericyte morphology 0.0262654061428393 0.169262170415318 2.44983181557142 0.333333333333333 22.1 22 1 abnormal dendritic cell morphology 0.0262654061428393 0.169262170415318 2.44983181557142 0.333333333333333 22.1 22 1 decreased thymocyte apoptosis 0.0262654061428393 0.169262170415318 2.44983181557142 0.333333333333333 22.1 22 1 liver vascular congestion 0.0262654061428393 0.169262170415318 2.44983181557142 0.333333333333333 22.1 22 1 bicuspid aortic valve 0.0262654061428393 0.169262170415318 2.44983181557142 0.333333333333333 22.1 22 1 increased leukocyte cell number 1.96392006031651e-11 3.15177493550795e-09 2.43293642373989 0.331034482758621 22.1 22 1 abnormal blood vessel morphology 1.96392006031651e-11 3.15177493550795e-09 2.43293642373989 0.331034482758621 22.1 22 1 lethality throughout fetal growth and development, incomplete penetrance 1.27459429767335e-13 3.17055331546246e-11 2.42245939305107 0.329608938547486 22.1 22 1 abnormal embryonic neuroepithelium morphology 2.66688630749644e-05 0.000990131296999612 2.4075933359926 0.327586206896552 22.1 22 1 prenatal lethality, complete penetrance 5.61942882880653e-20 3.10629538036806e-17 2.40577009226977 0.327338129496403 22.1 22 1 abnormal craniofacial development 0.000118309405189479 0.00346228994598622 2.39983524790669 0.326530612244898 22.1 22 1 failure to gastrulate 0.000194974408939748 0.00505207127330857 2.39657460218943 0.326086956521739 22.1 22 1 pallor 5.77098762675824e-13 1.24828971491836e-10 2.39383565978693 0.325714285714286 22.1 22 1 impaired macrophage phagocytosis 0.00032190527576863 0.00748354554649034 2.39285898265115 0.325581395348837 22.1 22 1 abnormal blood circulation 0.00032190527576863 0.00748354554649034 2.39285898265115 0.325581395348837 22.1 22 1 thrombocytopenia 7.20958713489412e-11 9.96324888780507e-09 2.38225024824531 0.324137931034483 22.1 22 1 enlarged liver sinusoidal spaces 0.00146907817985583 0.0239628326058451 2.37777793864285 0.323529411764706 22.1 22 1 abnormal nervous system development 0.00146907817985583 0.0239628326058451 2.37777793864285 0.323529411764706 22.1 22 1 abnormal capillary morphology 0.00245158646614234 0.0355856743272855 2.37080498281105 0.32258064516129 22.1 22 1 pale kidney 0.00245158646614234 0.0355856743272855 2.37080498281105 0.32258064516129 22.1 22 1 abnormal renal tubule epithelium morphology 0.0041077142192222 0.0523996877964883 2.36233782215815 0.321428571428571 22.1 22 1 extramedullary hematopoiesis 3.88818525553663e-08 3.45423600826692e-06 2.35738533196495 0.320754716981132 22.1 22 1 enlarged kidney 9.41222412217659e-05 0.00287274938698335 2.35738533196495 0.320754716981132 22.1 22 1 abnormal egg cylinder morphology 0.00691658941519984 0.0738412711172085 2.35183854294856 0.32 22.1 22 1 abnormal keratinocyte physiology 0.00691658941519984 0.0738412711172085 2.35183854294856 0.32 22.1 22 1 decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 0.00691658941519984 0.0738412711172085 2.35183854294856 0.32 22.1 22 1 embryonic lethality during organogenesis, complete penetrance 1.71820515587933e-36 4.27403532524982e-33 2.34921372314616 0.319642857142857 22.1 22 1 hydrops fetalis 6.35607861423973e-06 0.000310014618684732 2.34775548992261 0.319444444444444 22.1 22 1 thymus hypoplasia 5.19964901257708e-10 6.30933020428561e-08 2.34331738880744 0.318840579710145 22.1 22 1 abnormal abdominal fat pad morphology 0.0117179822495029 0.105802108332626 2.33847582395453 0.318181818181818 22.1 22 1 intracerebral hemorrhage 0.0117179822495029 0.105802108332626 2.33847582395453 0.318181818181818 22.1 22 1 increased skin papilloma incidence 0.0117179822495029 0.105802108332626 2.33847582395453 0.318181818181818 22.1 22 1 abnormal retinal outer plexiform layer morphology 0.0117179822495029 0.105802108332626 2.33847582395453 0.318181818181818 22.1 22 1 abnormal blood-brain barrier function 0.0117179822495029 0.105802108332626 2.33847582395453 0.318181818181818 22.1 22 1 abnormal mesenteric lymph node morphology 0.0117179822495029 0.105802108332626 2.33847582395453 0.318181818181818 22.1 22 1 pulmonary vascular congestion 0.0117179822495029 0.105802108332626 2.33847582395453 0.318181818181818 22.1 22 1 rough coat 0.0117179822495029 0.105802108332626 2.33847582395453 0.318181818181818 22.1 22 1 increased adenoma incidence 0.0117179822495029 0.105802108332626 2.33847582395453 0.318181818181818 22.1 22 1 liver fibrosis 0.00069512549271424 0.0139129807090305 2.33032782456793 0.317073170731707 22.1 22 1 muscular ventricular septal defect 4.54309397932672e-05 0.00152715490183449 2.32734022479285 0.316666666666667 22.1 22 1 abnormal placenta labyrinth morphology 3.09772237278758e-06 0.000165711492522777 2.32578969832729 0.316455696202532 22.1 22 1 abnormal facial morphology 7.44516790710686e-05 0.00234428546442131 2.32089329896239 0.315789473684211 22.1 22 1 decreased hair follicle number 0.0011516844708677 0.019894549453357 2.32089329896239 0.315789473684211 22.1 22 1 increased susceptibility to ischemic brain injury 0.0200094549911031 0.143646520318525 2.32089329896239 0.315789473684211 22.1 22 1 increased cell proliferation 0.000122145976687727 0.00353300136058977 2.31373004803967 0.314814814814815 22.1 22 1 abnormal small intestine morphology 0.000122145976687727 0.00353300136058977 2.31373004803967 0.314814814814815 22.1 22 1 vertebral transformation 0.000330043735848406 0.00763705853881776 2.2967173270982 0.3125 22.1 22 1 bradykinesia 0.00318814585243329 0.0438149878891039 2.2967173270982 0.3125 22.1 22 1 failure of tooth eruption 0.0345270959036185 0.206705538051146 2.2967173270982 0.3125 22.1 22 1 decreased mast cell number 0.0345270959036185 0.206705538051146 2.2967173270982 0.3125 22.1 22 1 abnormal hair follicle orientation 0.0345270959036185 0.206705538051146 2.2967173270982 0.3125 22.1 22 1 poor circulation 0.0345270959036185 0.206705538051146 2.2967173270982 0.3125 22.1 22 1 white spotting 0.0345270959036185 0.206705538051146 2.2967173270982 0.3125 22.1 22 1 increased pancreatic beta cell number 0.0345270959036185 0.206705538051146 2.2967173270982 0.3125 22.1 22 1 increased cochlear outer hair cell number 0.0345270959036185 0.206705538051146 2.2967173270982 0.3125 22.1 22 1 abnormal intestinal lipid absorption 0.0345270959036185 0.206705538051146 2.2967173270982 0.3125 22.1 22 1 decreased liver cholesterol level 0.0345270959036185 0.206705538051146 2.2967173270982 0.3125 22.1 22 1 embryonic lethality between somite formation and embryo turning, incomplete penetrance 0.0345270959036185 0.206705538051146 2.2967173270982 0.3125 22.1 22 1 decreased erythrocyte cell number 1.29562417671617e-10 1.72192979665818e-08 2.29379157254139 0.312101910828025 22.1 22 1 kidney cysts 1.06002683216429e-05 0.000455626901690795 2.28430263884362 0.310810810810811 22.1 22 1 glomerulosclerosis 9.59539462693142e-05 0.00291079806518194 2.28087789725615 0.310344827586207 22.1 22 1 abnormal parietal bone morphology 0.00533256686880972 0.0640809665998269 2.28087789725615 0.310344827586207 22.1 22 1 decreased trophoblast giant cell number 0.00533256686880972 0.0640809665998269 2.28087789725615 0.310344827586207 22.1 22 1 decreased bone strength 0.00533256686880972 0.0640809665998269 2.28087789725615 0.310344827586207 22.1 22 1 increased monocyte cell number 3.57823035114716e-07 2.54309942813673e-05 2.27834358848142 0.31 22.1 22 1 abnormal skeletal muscle fiber morphology 1.72784004948461e-05 0.000704590511982452 2.27730844827766 0.309859154929577 22.1 22 1 eyelids open at birth 0.000257859190216361 0.00619734044119031 2.26138321437362 0.307692307692308 22.1 22 1 failure of heart looping 0.00148427365642604 0.0241315733356847 2.26138321437362 0.307692307692308 22.1 22 1 ventricular hypoplasia 0.00895966678023088 0.091716753563063 2.26138321437362 0.307692307692308 22.1 22 1 increased thymocyte apoptosis 0.00895966678023088 0.091716753563063 2.26138321437362 0.307692307692308 22.1 22 1 spleen hyperplasia 1.35662699576332e-05 0.000563601710813808 2.2538452703257 0.306666666666667 22.1 22 1 pericardial effusion 7.51018877292139e-05 0.00234988610976628 2.2522647336705 0.306451612903226 22.1 22 1 abnormal respiratory system physiology 0.000423455940550873 0.00936308135218042 2.24984554491253 0.306122448979592 22.1 22 1 reduced long term depression 0.00246059738062034 0.0355856743272855 2.2456791642738 0.305555555555556 22.1 22 1 abnormal retinal blood vessel morphology 0.00246059738062034 0.0355856743272855 2.2456791642738 0.305555555555556 22.1 22 1 abnormal lymphocyte physiology 0.00069634818021077 0.0139129807090305 2.23680296204347 0.304347826086957 22.1 22 1 atrial septal defect 0.00069634818021077 0.0139129807090305 2.23680296204347 0.304347826086957 22.1 22 1 fragile skeleton 0.0151377587667227 0.118152988126733 2.23680296204347 0.304347826086957 22.1 22 1 dilated heart 0.0151377587667227 0.118152988126733 2.23680296204347 0.304347826086957 22.1 22 1 abnormal somite development 1.06236624313834e-05 0.000455626901690795 2.2327581103942 0.30379746835443 22.1 22 1 abnormal placenta morphology 1.06236624313834e-05 0.000455626901690795 2.2327581103942 0.30379746835443 22.1 22 1 anemia 8.80552250165515e-13 1.75229897782938e-10 2.22923084639674 0.303317535545024 22.1 22 1 increased mean corpuscular hemoglobin 9.42224271172399e-07 6.00665690188795e-05 2.22711983233765 0.303030303030303 22.1 22 1 belly spot 0.00409037525745016 0.0523126398607057 2.22711983233765 0.303030303030303 22.1 22 1 decreased brown adipose tissue amount 0.00409037525745016 0.0523126398607057 2.22711983233765 0.303030303030303 22.1 22 1 abnormal locomotor coordination 0.00409037525745016 0.0523126398607057 2.22711983233765 0.303030303030303 22.1 22 1 abnormal vasculogenesis 0.00114686436612883 0.0198803143605956 2.22194048389035 0.302325581395349 22.1 22 1 decreased hematocrit 3.74793713090848e-09 4.23772436960675e-07 2.21491643599608 0.301369863013699 22.1 22 1 decreased bone marrow cell number 2.80590057216375e-05 0.00103402632196405 2.21491643599608 0.301369863013699 22.1 22 1 perinatal lethality, complete penetrance 1.40894065206464e-12 2.69595374770061e-10 2.20829910136015 0.300469483568075 22.1 22 1 delayed eyelid opening 0.00682172317023627 0.0733003731575064 2.20484863401427 0.3 22.1 22 1 liver hemorrhage 0.00682172317023627 0.0733003731575064 2.20484863401427 0.3 22.1 22 1 abnormal basioccipital bone morphology 0.0257560528574998 0.168734157651955 2.20484863401427 0.3 22.1 22 1 brain inflammation 0.0257560528574998 0.168734157651955 2.20484863401427 0.3 22.1 22 1 decreased paired-pulse facilitation 0.0257560528574998 0.168734157651955 2.20484863401427 0.3 22.1 22 1 abnormal hyoid bone morphology 0.0257560528574998 0.168734157651955 2.20484863401427 0.3 22.1 22 1 abnormal lens epithelium morphology 0.0257560528574998 0.168734157651955 2.20484863401427 0.3 22.1 22 1 absent ductus venosus valve 0.0257560528574998 0.168734157651955 2.20484863401427 0.3 22.1 22 1 abnormal cell morphology 2.79067766621069e-07 2.04170902785268e-05 2.19195478235337 0.298245614035088 22.1 22 1 increased systemic arterial blood pressure 0.000883630438228764 0.0166517478416216 2.18921140965956 0.297872340425532 22.1 22 1 abnormal cell nucleus morphology 0.000883630438228764 0.0166517478416216 2.18921140965956 0.297872340425532 22.1 22 1 neuron degeneration 0.000883630438228764 0.0166517478416216 2.18921140965956 0.297872340425532 22.1 22 1 hydronephrosis 1.04821508385501e-05 0.000455626901690795 2.18734983533162 0.297619047619048 22.1 22 1 perinatal lethality, incomplete penetrance 8.52063106059758e-13 1.75229897782938e-10 2.17883272092856 0.29646017699115 22.1 22 1 abnormal maxilla morphology 0.000415619464996075 0.00927222797468823 2.17762828050793 0.296296296296296 22.1 22 1 abnormal heart valve morphology 0.0114210144500517 0.105221383127791 2.17762828050793 0.296296296296296 22.1 22 1 abnormal atrioventricular cushion morphology 0.0114210144500517 0.105221383127791 2.17762828050793 0.296296296296296 22.1 22 1 abnormal fetal cardiomyocyte proliferation 0.0114210144500517 0.105221383127791 2.17762828050793 0.296296296296296 22.1 22 1 abnormal cell cycle 3.50879026279807e-07 2.5298886315102e-05 2.17289430598508 0.295652173913043 22.1 22 1 abnormal adipose tissue morphology 0.0442243724306624 0.236322505738502 2.16161630785713 0.294117647058824 22.1 22 1 increased aggression towards mice 0.0442243724306624 0.236322505738502 2.16161630785713 0.294117647058824 22.1 22 1 abnormal cranial suture morphology 0.0442243724306624 0.236322505738502 2.16161630785713 0.294117647058824 22.1 22 1 increased regulatory T cell number 0.0442243724306624 0.236322505738502 2.16161630785713 0.294117647058824 22.1 22 1 increased circulating magnesium level 0.0442243724306624 0.236322505738502 2.16161630785713 0.294117647058824 22.1 22 1 decreased fatty acid level 0.0192109585744638 0.140416180205777 2.14360283862499 0.291666666666667 22.1 22 1 decreased B cell proliferation 3.44197907255671e-05 0.00124085839753403 2.13972652246111 0.291139240506329 22.1 22 1 decreased embryo size 4.1862322966239e-24 5.20662641892597e-21 2.13719637467214 0.290794979079498 22.1 22 1 abnormal podocyte morphology 0.00860950636736562 0.0894202383666888 2.13372448452994 0.290322580645161 22.1 22 1 abnormal sternum morphology 0.000116828177207086 0.00343917267222044 2.13028853527949 0.289855072463768 22.1 22 1 microcephaly 0.000116828177207086 0.00343917267222044 2.13028853527949 0.289855072463768 22.1 22 1 persistence of hyaloid vascular system 0.00393305592739029 0.0508232551656277 2.12748552404886 0.289473684210526 22.1 22 1 abnormal cell migration 0.00182021664572557 0.0279493142360639 2.12318757349523 0.288888888888889 22.1 22 1 abnormal placenta vasculature 0.000850327723102261 0.0162706939324375 2.12004676347526 0.288461538461538 22.1 22 1 embryonic lethality during organogenesis, incomplete penetrance 6.39073756968146e-12 1.09634204859191e-09 2.1089856499267 0.28695652173913 22.1 22 1 abnormal epidermis stratum corneum morphology 0.00138682668926037 0.0231083103381753 2.09985584191836 0.285714285714286 22.1 22 1 decreased circulating creatinine level 0.00138682668926037 0.0231083103381753 2.09985584191836 0.285714285714286 22.1 22 1 decreased triglyceride level 0.00649034070435388 0.0717543222314679 2.09985584191836 0.285714285714286 22.1 22 1 abnormal hormone level 0.0143463345423835 0.115303738850336 2.09985584191836 0.285714285714286 22.1 22 1 hypoxia 0.0143463345423835 0.115303738850336 2.09985584191836 0.285714285714286 22.1 22 1 abnormal mitotic spindle morphology 0.0143463345423835 0.115303738850336 2.09985584191836 0.285714285714286 22.1 22 1 prolonged QRS complex duration 0.0143463345423835 0.115303738850336 2.09985584191836 0.285714285714286 22.1 22 1 subcutaneous edema 0.0143463345423835 0.115303738850336 2.09985584191836 0.285714285714286 22.1 22 1 abnormal hematopoietic system physiology 0.0325013221086537 0.200862208062798 2.09985584191836 0.285714285714286 22.1 22 1 liver degeneration 0.0325013221086537 0.200862208062798 2.09985584191836 0.285714285714286 22.1 22 1 abnormal erythrocyte physiology 0.0325013221086537 0.200862208062798 2.09985584191836 0.285714285714286 22.1 22 1 abnormal clavicle morphology 0.0325013221086537 0.200862208062798 2.09985584191836 0.285714285714286 22.1 22 1 increased muscle cell glucose uptake 0.0325013221086537 0.200862208062798 2.09985584191836 0.285714285714286 22.1 22 1 abnormal renal glomerulus morphology 2.8135796042582e-06 0.000153819324518511 2.09022347567103 0.284403669724771 22.1 22 1 internal hemorrhage 0.000234784503172963 0.00575395518859847 2.08418527593389 0.283582089552239 22.1 22 1 decreased white adipose tissue amount 0.000234784503172963 0.00575395518859847 2.08418527593389 0.283582089552239 22.1 22 1 epidermal hyperplasia 0.000496589205394269 0.0107708636727623 2.0823570432357 0.283333333333333 22.1 22 1 respiratory distress 5.03211326674927e-09 5.56328077823947e-07 2.08164899935837 0.283236994219653 22.1 22 1 decreased circulating serum albumin level 9.37542227882292e-06 0.000426537696294606 2.07864517684848 0.282828282828283 22.1 22 1 abnormal heart ventricle morphology 8.55181931375137e-05 0.00264256528483932 2.07293461317581 0.282051282051282 22.1 22 1 abnormal ovary morphology 0.000179734049738667 0.00475626009281844 2.07028040752514 0.28169014084507 22.1 22 1 decreased brain weight 0.000804343075085759 0.0155704544690726 2.06301626574435 0.280701754385965 22.1 22 1 delayed bone ossification 0.000137548248736426 0.00386611603086848 2.05785872507999 0.28 22.1 22 1 mandible hypoplasia 0.0239921021363997 0.16373210991576 2.05785872507999 0.28 22.1 22 1 spontaneous skin ulceration 0.0239921021363997 0.16373210991576 2.05785872507999 0.28 22.1 22 1 abnormal primitive streak morphology 0.0239921021363997 0.16373210991576 2.05785872507999 0.28 22.1 22 1 abnormal vertebrae development 0.0239921021363997 0.16373210991576 2.05785872507999 0.28 22.1 22 1 embryonic growth arrest 4.60358910965839e-11 6.94025933956076e-09 2.05400746109045 0.279475982532751 22.1 22 1 delayed endochondral bone ossification 0.00369439631856556 0.0491269776544632 2.05102198512956 0.27906976744186 22.1 22 1 abnormal myocardium layer morphology 0.000105240383542124 0.00315404161519318 2.04669493452802 0.278481012658228 22.1 22 1 decreased tumor growth/size 0.00130264286033609 0.021968299085329 2.04152651297618 0.277777777777778 22.1 22 1 decreased platelet aggregation 0.00130264286033609 0.021968299085329 2.04152651297618 0.277777777777778 22.1 22 1 abnormal heart shape 0.0553877539877895 0.283200489300362 2.04152651297618 0.277777777777778 22.1 22 1 abnormal mammary gland morphology 0.0553877539877895 0.283200489300362 2.04152651297618 0.277777777777778 22.1 22 1 abnormal eye anterior chamber morphology 0.0553877539877895 0.283200489300362 2.04152651297618 0.277777777777778 22.1 22 1 increased effector memory CD4-positive, alpha-beta T cell number 0.0553877539877895 0.283200489300362 2.04152651297618 0.277777777777778 22.1 22 1 abnormal hypoglossal nerve topology 0.0553877539877895 0.283200489300362 2.04152651297618 0.277777777777778 22.1 22 1 increased adipocyte glucose uptake 0.0553877539877895 0.283200489300362 2.04152651297618 0.277777777777778 22.1 22 1 abnormal lung morphology 2.52152120068388e-06 0.000140950201948341 2.03809537597958 0.277310924369748 22.1 22 1 pulmonary hypoplasia 0.00279034063453633 0.0394373427750519 2.03283916611245 0.276595744680851 22.1 22 1 embryonic lethality, complete penetrance 2.69426562326066e-14 8.37748217232612e-12 2.02744701978324 0.275862068965517 22.1 22 1 decreased granulocyte number 0.017780150798983 0.132024254067076 2.02744701978324 0.275862068965517 22.1 22 1 increased mortality induced by gamma-irradiation 0.017780150798983 0.132024254067076 2.02744701978324 0.275862068965517 22.1 22 1 abnormal outer ear morphology 0.017780150798983 0.132024254067076 2.02744701978324 0.275862068965517 22.1 22 1 abnormal CD8-positive, alpha-beta T cell physiology 0.017780150798983 0.132024254067076 2.02744701978324 0.275862068965517 22.1 22 1 polychromatophilia 0.017780150798983 0.132024254067076 2.02744701978324 0.275862068965517 22.1 22 1 increased lymphocyte cell number 0.000355268291309998 0.00810761352874881 2.02377410851552 0.27536231884058 22.1 22 1 abnormal eye morphology 6.7391231487923e-07 4.59275858427969e-05 2.00921458255497 0.273381294964029 22.1 22 1 decreased T cell number 9.35254542943621e-08 7.88625652736358e-06 2.00855776183495 0.273291925465839 22.1 22 1 increased circulating calcium level 0.00159552164350515 0.0254414108219171 2.00440784910389 0.272727272727273 22.1 22 1 abnormal embryo turning 0.00159552164350515 0.0254414108219171 2.00440784910389 0.272727272727273 22.1 22 1 abnormal learning/memory/conditioning 0.00159552164350515 0.0254414108219171 2.00440784910389 0.272727272727273 22.1 22 1 abnormal platelet physiology 0.00159552164350515 0.0254414108219171 2.00440784910389 0.272727272727273 22.1 22 1 abnormal myelopoiesis 0.00453549691485685 0.0569800433116486 2.00440784910389 0.272727272727273 22.1 22 1 abnormal enterocyte morphology 0.0402950745558352 0.222742217683645 2.00440784910389 0.272727272727273 22.1 22 1 abnormal lysosome physiology 0.0402950745558352 0.222742217683645 2.00440784910389 0.272727272727273 22.1 22 1 abnormal occipital bone morphology 0.0402950745558352 0.222742217683645 2.00440784910389 0.272727272727273 22.1 22 1 increased mammary gland tumor incidence 0.0402950745558352 0.222742217683645 2.00440784910389 0.272727272727273 22.1 22 1 increased osteoblast cell number 0.0132211082019443 0.115303738850336 2.00440784910389 0.272727272727273 22.1 22 1 small heart 0.00341388107733862 0.0462780881737319 1.99048835015178 0.270833333333333 22.1 22 1 malocclusion 0.00985961972271303 0.0941489599241791 1.98635012073358 0.27027027027027 22.1 22 1 abnormal breathing pattern 0.00985961972271303 0.0941489599241791 1.98635012073358 0.27027027027027 22.1 22 1 increased erythroid progenitor cell number 0.00985961972271303 0.0941489599241791 1.98635012073358 0.27027027027027 22.1 22 1 skin inflammation 0.00985961972271303 0.0941489599241791 1.98635012073358 0.27027027027027 22.1 22 1 decreased susceptibility to hepatic steatosis 0.000915049821860873 0.0170708606259184 1.983197184034 0.26984126984127 22.1 22 1 abnormal skeleton morphology 9.43098423967973e-06 0.000426537696294606 1.98116833780993 0.269565217391304 22.1 22 1 embryonic lethality between implantation and somite formation, complete penetrance 1.31524285975901e-10 1.72192979665818e-08 1.97986407952302 0.269387755102041 22.1 22 1 decreased cardiac muscle contractility 2.55715669771349e-05 0.000963776861448832 1.97871031257691 0.269230769230769 22.1 22 1 abnormal snout morphology 0.00257295399126357 0.0365727031615322 1.97871031257691 0.269230769230769 22.1 22 1 kinked neural tube 0.00257295399126357 0.0365727031615322 1.97871031257691 0.269230769230769 22.1 22 1 abnormal leukocyte cell number 0.0295303677939357 0.186675450793939 1.97871031257691 0.269230769230769 22.1 22 1 abnormal Schwann cell morphology 0.0295303677939357 0.186675450793939 1.97871031257691 0.269230769230769 22.1 22 1 increased susceptibility to otitis media 0.0295303677939357 0.186675450793939 1.97871031257691 0.269230769230769 22.1 22 1 decreased circulating glycerol level 0.0295303677939357 0.186675450793939 1.97871031257691 0.269230769230769 22.1 22 1 neonatal lethality, incomplete penetrance 3.78786562933073e-11 5.88894734560013e-09 1.97871031257691 0.269230769230769 22.1 22 1 abnormal lipid homeostasis 2.67260087670248e-06 0.000147735437351054 1.97871031257691 0.269230769230769 22.1 22 1 absent gastric milk in neonates 0.000250663481716054 0.00605364476474451 1.97871031257691 0.269230769230769 22.1 22 1 lethality at weaning, incomplete penetrance 0.00737123303624044 0.0785265189620904 1.97181585155748 0.268292682926829 22.1 22 1 increased circulating free fatty acid level 0.000526205857895316 0.0112839402716776 1.96676638714888 0.267605633802817 22.1 22 1 increased circulating creatinine level 0.000145163868267779 0.00401216802573446 1.96556273574916 0.267441860465116 22.1 22 1 liver inflammation 8.71726046939234e-06 0.000405311876964737 1.95986545245713 0.266666666666667 22.1 22 1 albuminuria 0.00552287155817732 0.0661537085919541 1.95986545245713 0.266666666666667 22.1 22 1 gastrointestinal hemorrhage 0.0217650335730728 0.154027086808019 1.95986545245713 0.266666666666667 22.1 22 1 abnormal fat pad morphology 0.0217650335730728 0.154027086808019 1.95986545245713 0.266666666666667 22.1 22 1 abnormal cellular respiration 0.0217650335730728 0.154027086808019 1.95986545245713 0.266666666666667 22.1 22 1 prenatal lethality, incomplete penetrance 2.06768793050793e-12 3.80990646454702e-10 1.95825372099952 0.266447368421053 22.1 22 1 abnormal visceral yolk sac morphology 0.000303316672434202 0.00711792662905732 1.95366334659493 0.265822784810127 22.1 22 1 abnormal response to infection 0.000303316672434202 0.00711792662905732 1.95366334659493 0.265822784810127 22.1 22 1 kinked tail 4.88800720988578e-05 0.00161045270656833 1.94545467707142 0.264705882352941 22.1 22 1 abnormal extraembryonic tissue morphology 4.88800720988578e-05 0.00161045270656833 1.94545467707142 0.264705882352941 22.1 22 1 decreased mean corpuscular hemoglobin 0.000839152946149274 0.0161188645061492 1.94545467707142 0.264705882352941 22.1 22 1 increased width of hypertrophic chondrocyte zone 0.016114977500323 0.120923096627612 1.94545467707142 0.264705882352941 22.1 22 1 decreased osteoblast cell number 0.016114977500323 0.120923096627612 1.94545467707142 0.264705882352941 22.1 22 1 abnormal skin physiology 0.016114977500323 0.120923096627612 1.94545467707142 0.264705882352941 22.1 22 1 abnormal mesoderm development 0.00311741274150221 0.0429615744846911 1.94137615573584 0.264150943396226 22.1 22 1 increased circulating bilirubin level 0.00311741274150221 0.0429615744846911 1.94137615573584 0.264150943396226 22.1 22 1 atrioventricular septal defect 0.00311741274150221 0.0429615744846911 1.94137615573584 0.264150943396226 22.1 22 1 increased grip strength 0.000133246940475347 0.00376649732309574 1.9383284694631 0.263736263736264 22.1 22 1 decreased birth body size 2.16712713833373e-05 0.000869472380097605 1.93407774913533 0.263157894736842 22.1 22 1 increased hepatocellular carcinoma incidence 0.00234756005863016 0.0347592597966818 1.93407774913533 0.263157894736842 22.1 22 1 abnormal retinal outer nuclear layer morphology 0.011976249649614 0.10793811957759 1.93407774913533 0.263157894736842 22.1 22 1 flaky skin 0.0680228607723203 0.32291386673883 1.93407774913533 0.263157894736842 22.1 22 1 short vibrissae 0.0680228607723203 0.32291386673883 1.93407774913533 0.263157894736842 22.1 22 1 abnormal long term depression 0.0680228607723203 0.32291386673883 1.93407774913533 0.263157894736842 22.1 22 1 increased malignant tumor incidence 0.0680228607723203 0.32291386673883 1.93407774913533 0.263157894736842 22.1 22 1 decreased germ cell number 0.0680228607723203 0.32291386673883 1.93407774913533 0.263157894736842 22.1 22 1 abnormal neural crest cell migration 0.0680228607723203 0.32291386673883 1.93407774913533 0.263157894736842 22.1 22 1 abnormal cochlear inner hair cell morphology 0.0680228607723203 0.32291386673883 1.93407774913533 0.263157894736842 22.1 22 1 absent amnion 0.0680228607723203 0.32291386673883 1.93407774913533 0.263157894736842 22.1 22 1 increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 0.0680228607723203 0.32291386673883 1.93407774913533 0.263157894736842 22.1 22 1 increased double-negative T cell number 0.00177016094622953 0.0273495363586706 1.92773651061357 0.262295081967213 22.1 22 1 abnormal reproductive system morphology 0.00892818576330863 0.091716753563063 1.92486785509183 0.261904761904762 22.1 22 1 abnormal cytotoxic T cell physiology 0.00892818576330863 0.091716753563063 1.92486785509183 0.261904761904762 22.1 22 1 abnormal cell death 0.0066734311523935 0.0720908997031511 1.91725968175154 0.260869565217391 22.1 22 1 abnormal allantois morphology 0.0066734311523935 0.0720908997031511 1.91725968175154 0.260869565217391 22.1 22 1 embryonic lethality between implantation and placentation, complete penetrance 0.0066734311523935 0.0720908997031511 1.91725968175154 0.260869565217391 22.1 22 1 bidirectional circling 0.0491741271872866 0.256437403308963 1.91725968175154 0.260869565217391 22.1 22 1 abnormal cardiovascular development 0.0491741271872866 0.256437403308963 1.91725968175154 0.260869565217391 22.1 22 1 abnormal corneal stroma morphology 0.0491741271872866 0.256437403308963 1.91725968175154 0.260869565217391 22.1 22 1 abnormal chondrocyte physiology 0.0491741271872866 0.256437403308963 1.91725968175154 0.260869565217391 22.1 22 1 abnormal palatal shelf fusion at midline 0.0491741271872866 0.256437403308963 1.91725968175154 0.260869565217391 22.1 22 1 decreased spleen weight 0.00100993576550431 0.0180530897618375 1.91725968175154 0.260869565217391 22.1 22 1 increased B cell derived lymphoma incidence 0.00499936946504321 0.0618703061905223 1.91086881614571 0.26 22.1 22 1 short snout 5.35831664864997e-05 0.0017423284527473 1.90542474544444 0.259259259259259 22.1 22 1 abnormal axon morphology 5.35831664864997e-05 0.0017423284527473 1.90542474544444 0.259259259259259 22.1 22 1 abnormal mandible morphology 0.00375258219991035 0.0492588296690079 1.90542474544444 0.259259259259259 22.1 22 1 increased brain weight 0.0358686414642951 0.213452740771373 1.90542474544444 0.259259259259259 22.1 22 1 abnormal brain commissure morphology 0.0358686414642951 0.213452740771373 1.90542474544444 0.259259259259259 22.1 22 1 abnormal eye muscle morphology 0.0358686414642951 0.213452740771373 1.90542474544444 0.259259259259259 22.1 22 1 decreased circulating fructosamine level 0.0358686414642951 0.213452740771373 1.90542474544444 0.259259259259259 22.1 22 1 abnormal eyelid morphology 0.0263408691228839 0.169309849982361 1.89664398624884 0.258064516129032 22.1 22 1 decreased neuronal precursor cell number 0.0263408691228839 0.169309849982361 1.89664398624884 0.258064516129032 22.1 22 1 insulin resistance 1.04942861267102e-05 0.000455626901690795 1.893051857487 0.257575757575758 22.1 22 1 decreased total body fat amount 3.28747269609929e-12 5.84113452253356e-10 1.89238505514199 0.25748502994012 22.1 22 1 decreased B cell number 4.45884235473504e-08 3.89170889733453e-06 1.8908896052226 0.257281553398058 22.1 22 1 abnormal intestinal goblet cell morphology 0.0194465825450815 0.140416180205777 1.88987025772652 0.257142857142857 22.1 22 1 abnormal midbrain development 0.0194465825450815 0.140416180205777 1.88987025772652 0.257142857142857 22.1 22 1 abnormal hippocampus pyramidal cell morphology 0.0194465825450815 0.140416180205777 1.88987025772652 0.257142857142857 22.1 22 1 decreased bone mineralization 0.0194465825450815 0.140416180205777 1.88987025772652 0.257142857142857 22.1 22 1 increased urine protein level 0.0006914499999071 0.0139129807090305 1.88448601197801 0.256410256410256 22.1 22 1 increased embryonic tissue cell apoptosis 0.0006914499999071 0.0139129807090305 1.88448601197801 0.256410256410256 22.1 22 1 abnormal iris morphology 0.0144180331378117 0.115321084984909 1.88448601197801 0.256410256410256 22.1 22 1 acanthosis 0.0144180331378117 0.115321084984909 1.88448601197801 0.256410256410256 22.1 22 1 impaired macrophage chemotaxis 0.0144180331378117 0.115321084984909 1.88448601197801 0.256410256410256 22.1 22 1 abnormal left-right axis patterning 0.010727300884939 0.100316394553706 1.88010348636876 0.255813953488372 22.1 22 1 abnormal heart morphology 1.06236152769845e-08 1.07862216332649e-06 1.87714385868459 0.255411255411255 22.1 22 1 hepatic necrosis 0.00800477647280169 0.0843723791359924 1.87646692256534 0.25531914893617 22.1 22 1 cardiac hypertrophy 0.000173287624096134 0.00461019213838646 1.8748712874271 0.255102040816327 22.1 22 1 impaired hematopoiesis 0.0059881219149827 0.0694007476937551 1.87340080014285 0.254901960784314 22.1 22 1 increased kidney weight 0.0059881219149827 0.0694007476937551 1.87340080014285 0.254901960784314 22.1 22 1 abnormal trophoblast layer morphology 0.0059881219149827 0.0694007476937551 1.87340080014285 0.254901960784314 22.1 22 1 abnormal head morphology 0.00448913946307311 0.0566839310375348 1.87078065916363 0.254545454545455 22.1 22 1 abnormal rostral-caudal axis patterning 0.00448913946307311 0.0566839310375348 1.87078065916363 0.254545454545455 22.1 22 1 reduced female fertility 1.2598304003294e-08 1.25353124832775e-06 1.86905272136268 0.254310344827586 22.1 22 1 abnormal limb morphology 0.00108866318396238 0.0191354991112481 1.86187217983428 0.253333333333333 22.1 22 1 increased circulating alkaline phosphatase level 2.22951961615162e-06 0.000128975117329701 1.86005748960052 0.253086419753086 22.1 22 1 abnormal neural tube closure 0.000622775468732976 0.0128560496138861 1.85951089615662 0.253012048192771 22.1 22 1 preweaning lethality, incomplete penetrance 1.13571736542944e-13 2.97378625947973e-11 1.85085093156863 0.251833740831296 22.1 22 1 abnormal embryonic tissue morphology 7.78155960112271e-06 0.00037224287514986 1.84987300359474 0.251700680272109 22.1 22 1 abnormal intestinal epithelium morphology 0.00953507493795605 0.092993686344218 1.83737386167856 0.25 22.1 22 1 abnormal osteoclast morphology 0.00953507493795605 0.092993686344218 1.83737386167856 0.25 22.1 22 1 renal interstitial fibrosis 0.0127912355416331 0.115074858625 1.83737386167856 0.25 22.1 22 1 lymphoid hyperplasia 0.0430427437715989 0.232758315504027 1.83737386167856 0.25 22.1 22 1 abnormal brainstem morphology 0.0430427437715989 0.232758315504027 1.83737386167856 0.25 22.1 22 1 abnormal digestive system morphology 0.0591618500582276 0.292365585050477 1.83737386167856 0.25 22.1 22 1 curly vibrissae 0.0591618500582276 0.292365585050477 1.83737386167856 0.25 22.1 22 1 abnormal nursing 0.0591618500582276 0.292365585050477 1.83737386167856 0.25 22.1 22 1 apnea 0.0591618500582276 0.292365585050477 1.83737386167856 0.25 22.1 22 1 abnormal cardiac muscle contractility 0.0591618500582276 0.292365585050477 1.83737386167856 0.25 22.1 22 1 decreased ovulation rate 0.0591618500582276 0.292365585050477 1.83737386167856 0.25 22.1 22 1 abnormal tumor morphology 0.0591618500582276 0.292365585050477 1.83737386167856 0.25 22.1 22 1 increased body temperature 0.0591618500582276 0.292365585050477 1.83737386167856 0.25 22.1 22 1 abnormal cellular extravasation 0.0591618500582276 0.292365585050477 1.83737386167856 0.25 22.1 22 1 abnormal axial skeleton morphology 0.00129096904497664 0.0219200375384259 1.83737386167856 0.25 22.1 22 1 decreased circulating alanine transaminase level 0.00226822440736633 0.03398920610436 1.83737386167856 0.25 22.1 22 1 absent mesoderm 0.00400671576430373 0.0516409609518422 1.83737386167856 0.25 22.1 22 1 abnormal forebrain development 0.00171018044614267 0.0266087839232473 1.83737386167856 0.25 22.1 22 1 abnormal tooth morphology 0.0030123840555202 0.041979301614042 1.83737386167856 0.25 22.1 22 1 abnormal epidermis stratum granulosum morphology 0.023248696065871 0.16373210991576 1.83737386167856 0.25 22.1 22 1 impaired wound healing 0.023248696065871 0.16373210991576 1.83737386167856 0.25 22.1 22 1 abnormal vertebral body morphology 0.0315441893945148 0.197897026781477 1.83737386167856 0.25 22.1 22 1 kidney cortex cysts 0.0315441893945148 0.197897026781477 1.83737386167856 0.25 22.1 22 1 abnormal diaphragm morphology 0.0315441893945148 0.197897026781477 1.83737386167856 0.25 22.1 22 1 abnormal pericardium morphology 0.0821117967439271 0.352951883481936 1.83737386167856 0.25 22.1 22 1 anencephaly 0.0821117967439271 0.352951883481936 1.83737386167856 0.25 22.1 22 1 abnormal dopamine level 0.0821117967439271 0.352951883481936 1.83737386167856 0.25 22.1 22 1 decreased myocardial infarction size 0.0821117967439271 0.352951883481936 1.83737386167856 0.25 22.1 22 1 decreased skin tensile strength 0.0821117967439271 0.352951883481936 1.83737386167856 0.25 22.1 22 1 abnormal thymocyte activation 0.0821117967439271 0.352951883481936 1.83737386167856 0.25 22.1 22 1 abnormal induced retinal neovascularization 0.0821117967439271 0.352951883481936 1.83737386167856 0.25 22.1 22 1 abnormal neuron proliferation 0.0821117967439271 0.352951883481936 1.83737386167856 0.25 22.1 22 1 decreased muscle cell glucose uptake 0.0821117967439271 0.352951883481936 1.83737386167856 0.25 22.1 22 1 decreased cell proliferation 9.51580911808246e-07 6.00665690188795e-05 1.82744211107489 0.248648648648649 22.1 22 1 abnormal enzyme/coenzyme activity 6.29894823856605e-06 0.000310014618684732 1.82567084345131 0.248407643312102 22.1 22 1 abnormal cardiovascular system physiology 3.2102068470871e-05 0.001174321990019 1.82355902061331 0.24812030075188 22.1 22 1 abnormal bone mineralization 7.27774231785724e-05 0.00232094666867562 1.82218895373081 0.247933884297521 22.1 22 1 abnormal embryo size 0.000125849459126233 0.00361908126678039 1.82111391599999 0.247787610619469 22.1 22 1 increased macrophage cell number 0.00631212098084843 0.0699394251218729 1.80513923252631 0.245614035087719 22.1 22 1 abnormal placenta development 0.0084294682293398 0.0877334820940701 1.80270643032614 0.245283018867925 22.1 22 1 absent kidney 0.0112829242346877 0.104628740559253 1.79987643593002 0.244897959183673 22.1 22 1 cyanosis 1.17546745199517e-06 7.21969206626665e-05 1.79909523956026 0.244791666666667 22.1 22 1 postnatal lethality, incomplete penetrance 7.91890844454542e-17 3.58150631923759e-14 1.79855610403747 0.244718309859155 22.1 22 1 oxidative stress 0.000775288004988245 0.0152452878451246 1.79654333141904 0.244444444444444 22.1 22 1 small placenta 0.0151427650656923 0.118152988126733 1.79654333141904 0.244444444444444 22.1 22 1 Leydig cell hyperplasia 0.0203873271026729 0.145728379792813 1.79255986505226 0.24390243902439 22.1 22 1 increased bone trabecula number 0.0203873271026729 0.145728379792813 1.79255986505226 0.24390243902439 22.1 22 1 increased rib number 0.00179262190569327 0.0276108172780929 1.79026171137911 0.243589743589744 22.1 22 1 preweaning lethality, complete penetrance 4.18232956518897e-21 3.46784826446919e-18 1.78771510866022 0.243243243243243 22.1 22 1 decreased IgG level 0.00022831863180739 0.00567942596620883 1.78771510866022 0.243243243243243 22.1 22 1 decreased T cell proliferation 2.29349859774452e-05 0.00091281244190232 1.78771510866022 0.243243243243243 22.1 22 1 increased circulating phosphate level 0.0275523277476004 0.176186157511969 1.78771510866022 0.243243243243243 22.1 22 1 increased T cell proliferation 0.000300584615238325 0.00711792662905732 1.78585870667823 0.242990654205607 22.1 22 1 abnormal tooth development 0.0374075753761374 0.219979536047616 1.78169586587012 0.242424242424242 22.1 22 1 dilated heart atrium 0.0374075753761374 0.219979536047616 1.78169586587012 0.242424242424242 22.1 22 1 increased cardiomyocyte apoptosis 0.0374075753761374 0.219979536047616 1.78169586587012 0.242424242424242 22.1 22 1 increased inflammatory response 0.00068832096348441 0.0139129807090305 1.7793515292045 0.242105263157895 22.1 22 1 prenatal lethality 0.00556942872731193 0.0664458223462275 1.77810373710829 0.241935483870968 22.1 22 1 abnormal glucose homeostasis 3.60086761191137e-06 0.000190577833715522 1.77680109700784 0.241758241758242 22.1 22 1 enlarged heart 1.95066660316514e-07 1.51633849230415e-05 1.77401614231034 0.241379310344828 22.1 22 1 abnormal middle ear morphology 0.0510808415356131 0.264165474677417 1.77401614231034 0.241379310344828 22.1 22 1 abnormal microglial cell morphology 0.0510808415356131 0.264165474677417 1.77401614231034 0.241379310344828 22.1 22 1 increased susceptibility to induced arthritis 0.0510808415356131 0.264165474677417 1.77401614231034 0.241379310344828 22.1 22 1 blood in lymph vessels 0.0510808415356131 0.264165474677417 1.77401614231034 0.241379310344828 22.1 22 1 abnormal chondrocyte morphology 0.00991238331184181 0.0942908355189541 1.76932297791269 0.240740740740741 22.1 22 1 decreased double-positive T cell number 0.000609784667004998 0.0126932163947693 1.76387890721142 0.24 22.1 22 1 decreased heart rate 0.000609784667004998 0.0126932163947693 1.76387890721142 0.24 22.1 22 1 abnormal hindlimb morphology 0.0132672046882596 0.115303738850336 1.76387890721142 0.24 22.1 22 1 decreased circulating alkaline phosphatase level 0.0132672046882596 0.115303738850336 1.76387890721142 0.24 22.1 22 1 testicular atrophy 0.0132672046882596 0.115303738850336 1.76387890721142 0.24 22.1 22 1 abnormal axon extension 0.0132672046882596 0.115303738850336 1.76387890721142 0.24 22.1 22 1 decreased oocyte number 0.0132672046882596 0.115303738850336 1.76387890721142 0.24 22.1 22 1 ruffled hair 0.070268086244068 0.325399434904965 1.76387890721142 0.24 22.1 22 1 diaphragmatic hernia 0.070268086244068 0.325399434904965 1.76387890721142 0.24 22.1 22 1 postnatal growth retardation 1.3844791655051e-16 5.73981987365657e-14 1.7533110052619 0.238562091503268 22.1 22 1 abnormal muscle morphology 0.0239683087712243 0.16373210991576 1.7498798682653 0.238095238095238 22.1 22 1 abnormal scapula morphology 0.0976150700674502 0.394860429061833 1.7498798682653 0.238095238095238 22.1 22 1 absent segment of posterior cerebral artery 0.0976150700674502 0.394860429061833 1.7498798682653 0.238095238095238 22.1 22 1 abnormal retinal pigment epithelium morphology 0.00244979213975334 0.0355856743272855 1.74550516859463 0.2375 22.1 22 1 decreased body size 1.00860214366469e-20 7.16827952104548e-18 1.7406699742218 0.236842105263158 22.1 22 1 abnormal reproductive system physiology 0.0323862830193893 0.200862208062798 1.7406699742218 0.236842105263158 22.1 22 1 decreased body weight 1.42091382042321e-31 2.35634875220182e-28 1.73942016630636 0.236672051696284 22.1 22 1 cleft palate 0.000141018460441729 0.00394138674549215 1.73919357899345 0.236641221374046 22.1 22 1 hypoglycemia 0.00123500520756724 0.0211139206448351 1.7385903207281 0.236559139784946 22.1 22 1 enlarged spleen 2.60947004859916e-08 2.36038427123287e-06 1.73529753602975 0.236111111111111 22.1 22 1 abnormal heart left ventricle morphology 0.00430108331971326 0.0545864528458506 1.73529753602975 0.236111111111111 22.1 22 1 decreased bone mineral content 2.30894757033227e-06 0.000131684672385014 1.7313715235048 0.235576923076923 22.1 22 1 abnormal gluconeogenesis 0.0155069224646525 0.118926926072099 1.72929304628571 0.235294117647059 22.1 22 1 failure of chorioallantoic fusion 0.0155069224646525 0.118926926072099 1.72929304628571 0.235294117647059 22.1 22 1 microphthalmia 4.88727781652422e-05 0.00161045270656833 1.72929304628571 0.235294117647059 22.1 22 1 abnormal spleen red pulp morphology 0.0439591439533111 0.236173586574215 1.72929304628571 0.235294117647059 22.1 22 1 abnormal brown adipose tissue morphology 0.0439591439533111 0.236173586574215 1.72929304628571 0.235294117647059 22.1 22 1 abnormal direction of heart looping 0.0439591439533111 0.236173586574215 1.72929304628571 0.235294117647059 22.1 22 1 decreased regulatory T cell number 0.0439591439533111 0.236173586574215 1.72929304628571 0.235294117647059 22.1 22 1 abnormal skeleton development 0.00284758957987023 0.039794264493973 1.72395572206877 0.234567901234568 22.1 22 1 abnormal osteoclast physiology 0.00759012817370471 0.0805136197530511 1.72253799532365 0.234375 22.1 22 1 decreased bone trabecula number 0.0207989327176275 0.148457231377614 1.72009467901823 0.234042553191489 22.1 22 1 impaired glucose tolerance 3.73148294066631e-07 2.61466586335421e-05 1.71883361253801 0.233870967741935 22.1 22 1 abnormal dendritic cell physiology 0.000725864575416211 0.0143300645345065 1.71717183334445 0.233644859813084 22.1 22 1 decreased leukocyte cell number 0.000144109212987587 0.00400527002577233 1.71667046930552 0.233576642335766 22.1 22 1 kyphosis 7.40017776320534e-05 0.00234428546442131 1.71488227089999 0.233333333333333 22.1 22 1 abnormal retina morphology 3.0807562626696e-06 0.000165711492522777 1.71488227089999 0.233333333333333 22.1 22 1 abnormal eating behavior 0.0101063452240145 0.0957696523608989 1.71488227089999 0.233333333333333 22.1 22 1 increased erythrocyte cell number 0.0101063452240145 0.0957696523608989 1.71488227089999 0.233333333333333 22.1 22 1 decreased bone mineral density 1.71419172507122e-07 1.37550061810151e-05 1.71304029209129 0.233082706766917 22.1 22 1 abnormal fertility/fecundity 0.00499360183932171 0.0618703061905223 1.71152633690606 0.232876712328767 22.1 22 1 astrocytosis 0.00499360183932171 0.0618703061905223 1.71152633690606 0.232876712328767 22.1 22 1 abnormal axon guidance 0.0279807354034319 0.178010433033342 1.70918498760797 0.232558139534884 22.1 22 1 abnormal double-strand DNA break repair 0.0279807354034319 0.178010433033342 1.70918498760797 0.232558139534884 22.1 22 1 abnormal coat/hair pigmentation 0.000637950313047653 0.0130609169029303 1.70613287155867 0.232142857142857 22.1 22 1 hyperkeratosis 0.00662428162397925 0.0720908997031511 1.70423082822359 0.231884057971014 22.1 22 1 decreased birth weight 0.00165730768676313 0.0263016021425491 1.70198841923909 0.231578947368421 22.1 22 1 abnormal cranium morphology 0.000217990589701506 0.00553317950900506 1.70025640931449 0.23134328358209 22.1 22 1 premature death 1.82524004647665e-20 1.13507115390267e-17 1.69866387212095 0.231126596980256 22.1 22 1 abnormal hair growth 0.0180210458371816 0.133216497830577 1.69603741078021 0.230769230769231 22.1 22 1 abnormal heart looping 0.0377767579838625 0.220066527552162 1.69603741078021 0.230769230769231 22.1 22 1 small lens 0.0377767579838625 0.220066527552162 1.69603741078021 0.230769230769231 22.1 22 1 decreased B-1 B cell number 0.0377767579838625 0.220066527552162 1.69603741078021 0.230769230769231 22.1 22 1 abnormal response to injury 0.0377767579838625 0.220066527552162 1.69603741078021 0.230769230769231 22.1 22 1 abnormal xiphoid process morphology 0.0824894017791078 0.352951883481936 1.69603741078021 0.230769230769231 22.1 22 1 abnormal kidney cortex morphology 0.0824894017791078 0.352951883481936 1.69603741078021 0.230769230769231 22.1 22 1 heart inflammation 0.0824894017791078 0.352951883481936 1.69603741078021 0.230769230769231 22.1 22 1 increased leukemia incidence 0.0824894017791078 0.352951883481936 1.69603741078021 0.230769230769231 22.1 22 1 abnormal Mullerian duct morphology 0.0824894017791078 0.352951883481936 1.69603741078021 0.230769230769231 22.1 22 1 decreased bone resorption 0.0824894017791078 0.352951883481936 1.69603741078021 0.230769230769231 22.1 22 1 decreased Peyer's patch number 0.0824894017791078 0.352951883481936 1.69603741078021 0.230769230769231 22.1 22 1 decreased monocyte cell number 0.00879926911568331 0.0910111514563919 1.69603741078021 0.230769230769231 22.1 22 1 abnormal intestine morphology 0.00577450471078879 0.0679152740807901 1.68839760262354 0.22972972972973 22.1 22 1 abnormal long bone morphology 0.0117060144470756 0.105802108332626 1.68676944678688 0.229508196721311 22.1 22 1 retinal degeneration 0.00191097293451019 0.0290736707926244 1.68425937320535 0.229166666666667 22.1 22 1 abnormal cardiovascular system morphology 0.024147647192665 0.164342742521899 1.68425937320535 0.229166666666667 22.1 22 1 curly tail 0.024147647192665 0.164342742521899 1.68425937320535 0.229166666666667 22.1 22 1 domed cranium 0.00765336252992815 0.0810116565667926 1.67988467353469 0.228571428571429 22.1 22 1 increased carcinoma incidence 0.051222125111305 0.264346548162596 1.67988467353469 0.228571428571429 22.1 22 1 decreased bone volume 0.051222125111305 0.264346548162596 1.67988467353469 0.228571428571429 22.1 22 1 abnormal craniofacial bone morphology 0.0155995165257522 0.118926926072099 1.67620071591729 0.228070175438596 22.1 22 1 abnormal embryo development 0.000288244137553743 0.00689430088620131 1.67525263858928 0.227941176470588 22.1 22 1 increased blood urea nitrogen level 0.000193125976373298 0.00504429763458382 1.67264379132117 0.227586206896552 22.1 22 1 increased circulating cholesterol level 4.47905500678366e-05 0.00152196982435583 1.67033987425324 0.227272727272727 22.1 22 1 increased sensitivity to xenobiotic induced morbidity/mortality 0.00111059112319451 0.0193610687026219 1.67033987425324 0.227272727272727 22.1 22 1 abnormal suckling behavior 0.00331838557201036 0.045354308298768 1.67033987425324 0.227272727272727 22.1 22 1 osteoporosis 0.0324482353627845 0.200862208062798 1.67033987425324 0.227272727272727 22.1 22 1 hypertension 0.0324482353627845 0.200862208062798 1.67033987425324 0.227272727272727 22.1 22 1 muscular atrophy 0.0324482353627845 0.200862208062798 1.67033987425324 0.227272727272727 22.1 22 1 lethality, incomplete penetrance 0.0324482353627845 0.200862208062798 1.67033987425324 0.227272727272727 22.1 22 1 abnormal facial nerve morphology 0.114473892276749 0.394860429061833 1.67033987425324 0.227272727272727 22.1 22 1 abnormal tracheal cartilage morphology 0.114473892276749 0.394860429061833 1.67033987425324 0.227272727272727 22.1 22 1 decreased cardiac output 0.114473892276749 0.394860429061833 1.67033987425324 0.227272727272727 22.1 22 1 parakeratosis 0.114473892276749 0.394860429061833 1.67033987425324 0.227272727272727 22.1 22 1 prolonged PR interval 0.114473892276749 0.394860429061833 1.67033987425324 0.227272727272727 22.1 22 1 abnormal circulating lipid level 0.114473892276749 0.394860429061833 1.67033987425324 0.227272727272727 22.1 22 1 failure of palatal shelf elevation 0.114473892276749 0.394860429061833 1.67033987425324 0.227272727272727 22.1 22 1 increased circulating creatine kinase level 0.114473892276749 0.394860429061833 1.67033987425324 0.227272727272727 22.1 22 1 no abnormal phenotype detected 2.20322481285844e-37 1.09610434439708e-33 1.66052000871008 0.225936599423631 22.1 22 1 abnormal retinal photoreceptor layer morphology 0.0698211782861939 0.325399434904965 1.65956348796773 0.225806451612903 22.1 22 1 decreased thymus weight 0.0698211782861939 0.325399434904965 1.65956348796773 0.225806451612903 22.1 22 1 abnormal hepatocyte morphology 0.00127302357139445 0.0216893570811211 1.65529176727798 0.225225225225225 22.1 22 1 respiratory failure 0.000193660472001107 0.00504429763458382 1.65485327939261 0.225165562913907 22.1 22 1 decreased circulating phosphate level 0.0437469770720906 0.236173586574215 1.65363647551071 0.225 22.1 22 1 reduced male fertility 6.22494033056565e-06 0.000309690781445641 1.65120822811642 0.224669603524229 22.1 22 1 abnormal spermiogenesis 0.0179616911424792 0.132975317609872 1.64730070357388 0.224137931034483 22.1 22 1 thrombocytosis 0.0179616911424792 0.132975317609872 1.64730070357388 0.224137931034483 22.1 22 1 rib fusion 0.0116723154989752 0.105802108332626 1.64540942836886 0.223880597014925 22.1 22 1 neonatal lethality, complete penetrance 2.65634852605456e-10 3.38854715823627e-08 1.64396608676503 0.223684210526316 22.1 22 1 cleft secondary palate 0.00331102753177625 0.045354308298768 1.64190855724467 0.223404255319149 22.1 22 1 cataract 0.000968620557404202 0.0175232264475851 1.63997005835773 0.223140495867769 22.1 22 1 postnatal lethality 0.000129614028070645 0.00370591833133023 1.63814055137607 0.22289156626506 22.1 22 1 abnormal bone structure 3.92956348142292e-05 0.0013767308676112 1.63745235341302 0.22279792746114 22.1 22 1 abnormal neural tube morphology 0.000168901308708489 0.00451765597217597 1.63322121038094 0.222222222222222 22.1 22 1 decreased heart weight 0.00661540498733583 0.0720908997031511 1.63322121038094 0.222222222222222 22.1 22 1 diluted coat color 0.0239471807107871 0.16373210991576 1.63322121038094 0.222222222222222 22.1 22 1 neurodegeneration 0.0239471807107871 0.16373210991576 1.63322121038094 0.222222222222222 22.1 22 1 thin epidermis 0.0958096190119113 0.394860429061833 1.63322121038094 0.222222222222222 22.1 22 1 abnormal palate morphology 0.0958096190119113 0.394860429061833 1.63322121038094 0.222222222222222 22.1 22 1 gliosis 0.0154897469637214 0.118926926072099 1.63322121038094 0.222222222222222 22.1 22 1 abnormal cartilage development 0.0373926554476679 0.219979536047616 1.63322121038094 0.222222222222222 22.1 22 1 altered response to myocardial infarction 0.0373926554476679 0.219979536047616 1.63322121038094 0.222222222222222 22.1 22 1 abnormal systemic arterial blood pressure 0.0592145334100005 0.292365585050477 1.63322121038094 0.222222222222222 22.1 22 1 abnormal pharyngeal arch morphology 0.0592145334100005 0.292365585050477 1.63322121038094 0.222222222222222 22.1 22 1 narrow eye opening 0.0592145334100005 0.292365585050477 1.63322121038094 0.222222222222222 22.1 22 1 increased spleen weight 0.00166004081864531 0.0263016021425491 1.62599456785714 0.221238938053097 22.1 22 1 alopecia 0.00378032640671241 0.0494924312457743 1.62462530927368 0.221052631578947 22.1 22 1 increased oxygen consumption 0.00573235056033584 0.0675792512741015 1.62372573822757 0.22093023255814 22.1 22 1 increased circulating chloride level 0.0319908473233863 0.200194296143204 1.61688899827714 0.22 22.1 22 1 decreased respiratory quotient 0.0319908473233863 0.200194296143204 1.61688899827714 0.22 22.1 22 1 small spleen 0.00496693534516589 0.0618703061905223 1.61527372455258 0.21978021978022 22.1 22 1 sparse hair 0.00754844530550073 0.0802425542625345 1.61330387854703 0.219512195121951 22.1 22 1 arrested B cell differentiation 0.0503168786259894 0.261301118125571 1.61330387854703 0.219512195121951 22.1 22 1 abnormal cholesterol homeostasis 0.0503168786259894 0.261301118125571 1.61330387854703 0.219512195121951 22.1 22 1 seizures 0.00188870559705091 0.0288230378691052 1.61173145761277 0.219298245614035 22.1 22 1 spleen hypoplasia 0.00284694447421821 0.039794264493973 1.60988947880407 0.219047619047619 22.1 22 1 decreased circulating HDL cholesterol level 0.00109235814021999 0.0191354991112481 1.60770212896874 0.21875 22.1 22 1 decreased lymphocyte cell number 0.00109235814021999 0.0191354991112481 1.60770212896874 0.21875 22.1 22 1 scoliosis 0.0805387351758641 0.352951883481936 1.60770212896874 0.21875 22.1 22 1 abnormal nervous system physiology 0.0021437550851139 0.0322210922913645 1.59771640145962 0.217391304347826 22.1 22 1 abnormal locomotor behavior 0.00564735829470359 0.0667354097770793 1.59771640145962 0.217391304347826 22.1 22 1 delayed wound healing 0.0428337942597541 0.232133035340171 1.59771640145962 0.217391304347826 22.1 22 1 abnormal myelin sheath morphology 0.0428337942597541 0.232133035340171 1.59771640145962 0.217391304347826 22.1 22 1 abnormal cranial nerve morphology 0.13261271591271 0.430645079416275 1.59771640145962 0.217391304347826 22.1 22 1 blistering 0.13261271591271 0.430645079416275 1.59771640145962 0.217391304347826 22.1 22 1 abnormal circulating insulin level 0.13261271591271 0.430645079416275 1.59771640145962 0.217391304347826 22.1 22 1 abnormal postnatal growth 0.13261271591271 0.430645079416275 1.59771640145962 0.217391304347826 22.1 22 1 increased susceptibility to age related obesity 0.13261271591271 0.430645079416275 1.59771640145962 0.217391304347826 22.1 22 1 abnormal Wolffian duct morphology 0.13261271591271 0.430645079416275 1.59771640145962 0.217391304347826 22.1 22 1 decreased epididymis weight 0.13261271591271 0.430645079416275 1.59771640145962 0.217391304347826 22.1 22 1 abnormal basicranium morphology 0.13261271591271 0.430645079416275 1.59771640145962 0.217391304347826 22.1 22 1 decreased effector memory CD8-positive, alpha-beta T cell number 0.13261271591271 0.430645079416275 1.59771640145962 0.217391304347826 22.1 22 1 increased insulin sensitivity 0.000718206366393975 0.0142353652303188 1.59324726467232 0.216783216783217 22.1 22 1 small seminiferous tubules 0.0131119030365354 0.115303738850336 1.58908009658686 0.216216216216216 22.1 22 1 increased brown adipose tissue amount 0.0679489349720419 0.32291386673883 1.58908009658686 0.216216216216216 22.1 22 1 abnormal vocalization 0.0679489349720419 0.32291386673883 1.58908009658686 0.216216216216216 22.1 22 1 abnormal calcium ion homeostasis 0.0679489349720419 0.32291386673883 1.58908009658686 0.216216216216216 22.1 22 1 abnormal behavior 3.95141479795985e-06 0.000206587188456282 1.58622203885919 0.215827338129496 22.1 22 1 abnormal cued conditioning behavior 0.0365239266595381 0.216060089335555 1.58518529242856 0.215686274509804 22.1 22 1 abnormal gastrulation 0.0365239266595381 0.216060089335555 1.58518529242856 0.215686274509804 22.1 22 1 abnormal cervical vertebrae morphology 0.0365239266595381 0.216060089335555 1.58518529242856 0.215686274509804 22.1 22 1 abnormal dendritic spine morphology 0.0365239266595381 0.216060089335555 1.58518529242856 0.215686274509804 22.1 22 1 abnormal nervous system morphology 0.0112935947096119 0.104628740559253 1.58153699486256 0.215189873417722 22.1 22 1 polydactyly 0.00553164678879455 0.0661537085919541 1.57489188143877 0.214285714285714 22.1 22 1 decreased exploration in new environment 0.00973235760477939 0.0936527641852562 1.57489188143877 0.214285714285714 22.1 22 1 abnormal seminal vesicle morphology 0.0311901636196523 0.196419068364266 1.57489188143877 0.214285714285714 22.1 22 1 abnormal optic nerve morphology 0.0575028522227436 0.292365585050477 1.57489188143877 0.214285714285714 22.1 22 1 reddish skin 0.110200584986542 0.394860429061833 1.57489188143877 0.214285714285714 22.1 22 1 straub tail 0.110200584986542 0.394860429061833 1.57489188143877 0.214285714285714 22.1 22 1 abnormal retinal inner nuclear layer morphology 0.110200584986542 0.394860429061833 1.57489188143877 0.214285714285714 22.1 22 1 premature aging 0.110200584986542 0.394860429061833 1.57489188143877 0.214285714285714 22.1 22 1 increased triglyceride level 0.110200584986542 0.394860429061833 1.57489188143877 0.214285714285714 22.1 22 1 abnormal cytokine secretion 0.000612810155328186 0.0127030438448239 1.57489188143877 0.214285714285714 22.1 22 1 increased neutrophil cell number 0.000916164781330694 0.0170708606259184 1.57127144033201 0.213793103448276 22.1 22 1 increased circulating triglyceride level 0.000916164781330694 0.0170708606259184 1.57127144033201 0.213793103448276 22.1 22 1 decreased neutrophil cell number 0.00274269120686715 0.0388743269349404 1.57040500998168 0.213675213675214 22.1 22 1 anophthalmia 0.00839102170642896 0.0875164213616018 1.56899340997271 0.213483146067416 22.1 22 1 abnormal neurocranium morphology 0.0148638113643203 0.118152988126733 1.56789236196571 0.213333333333333 22.1 22 1 decreased circulating cholesterol level 0.000234564324712329 0.00575395518859847 1.56628591487353 0.213114754098361 22.1 22 1 abnormal maternal nurturing 0.0266712656363606 0.170991683686719 1.56628591487353 0.213114754098361 22.1 22 1 abnormal NK cell physiology 0.0266712656363606 0.170991683686719 1.56628591487353 0.213114754098361 22.1 22 1 increased circulating glucose level 0.00118967524737521 0.0204797036529123 1.56372243547112 0.212765957446809 22.1 22 1 abnormal T-helper 1 physiology 0.0487891622441126 0.256040171059557 1.56372243547112 0.212765957446809 22.1 22 1 increased circulating insulin level 0.000599500795509512 0.0126703947057669 1.56176778242678 0.2125 22.1 22 1 postnatal lethality, complete penetrance 1.54168475139937e-07 1.2573576456085e-05 1.56129177883567 0.212435233160622 22.1 22 1 abnormal ovarian folliculogenesis 0.0921509705065597 0.389177485798077 1.55898388263636 0.212121212121212 22.1 22 1 abnormal epidermis stratum basale morphology 0.0921509705065597 0.389177485798077 1.55898388263636 0.212121212121212 22.1 22 1 decreased systemic arterial blood pressure 0.0921509705065597 0.389177485798077 1.55898388263636 0.212121212121212 22.1 22 1 abnormal QRS complex 0.0921509705065597 0.389177485798077 1.55898388263636 0.212121212121212 22.1 22 1 decreased body length 1.05221331922688e-05 0.000455626901690795 1.55573261280813 0.211678832116788 22.1 22 1 abnormal skin condition 0.0414881141972435 0.225824253972961 1.55470095988186 0.211538461538462 22.1 22 1 abnormal kidney morphology 0.000392573334579312 0.00883734090286007 1.55389332301958 0.211428571428571 22.1 22 1 atelectasis 0.0195718450825637 0.140707990297333 1.55271030564386 0.211267605633803 22.1 22 1 corneal opacity 0.0195718450825637 0.140707990297333 1.55271030564386 0.211267605633803 22.1 22 1 abnormal CD4-positive, alpha-beta T cell physiology 0.0195718450825637 0.140707990297333 1.55271030564386 0.211267605633803 22.1 22 1 increased bone marrow cell number 0.0774323088260826 0.341368825259283 1.54726219930826 0.210526315789474 22.1 22 1 abnormal compact bone morphology 0.0774323088260826 0.341368825259283 1.54726219930826 0.210526315789474 22.1 22 1 abnormal humoral immune response 0.006066982439621 0.0694007476937551 1.53989428407346 0.20952380952381 22.1 22 1 small ovary 0.0106595044974185 0.0998701221744957 1.53451003832495 0.208791208791209 22.1 22 1 abnormal B cell differentiation 0.0106595044974185 0.0998701221744957 1.53451003832495 0.208791208791209 22.1 22 1 abnormal locomotor activation 0.0106595044974185 0.0998701221744957 1.53451003832495 0.208791208791209 22.1 22 1 hydroencephaly 0.00451950363986214 0.0569228622995295 1.53380774540123 0.208695652173913 22.1 22 1 thymus atrophy 0.0552737714681778 0.283200489300362 1.53114488473214 0.208333333333333 22.1 22 1 abnormal foregut morphology 0.151941891137574 0.47083387676354 1.53114488473214 0.208333333333333 22.1 22 1 abnormal adrenal gland morphology 0.151941891137574 0.47083387676354 1.53114488473214 0.208333333333333 22.1 22 1 decreased body height 0.151941891137574 0.47083387676354 1.53114488473214 0.208333333333333 22.1 22 1 ocular hypertelorism 0.151941891137574 0.47083387676354 1.53114488473214 0.208333333333333 22.1 22 1 hemolytic anemia 0.151941891137574 0.47083387676354 1.53114488473214 0.208333333333333 22.1 22 1 abnormal osteoblast morphology 0.151941891137574 0.47083387676354 1.53114488473214 0.208333333333333 22.1 22 1 abnormal retinal ganglion layer morphology 0.151941891137574 0.47083387676354 1.53114488473214 0.208333333333333 22.1 22 1 abnormal T cell differentiation 0.00790181887926901 0.0834640104551238 1.52811291466336 0.207920792079208 22.1 22 1 abnormal spleen morphology 0.000712209605106018 0.0141729711416097 1.52058526483743 0.206896551724138 22.1 22 1 cochlear ganglion degeneration 0.0398831421293275 0.221449366175674 1.52058526483743 0.206896551724138 22.1 22 1 lordosis 0.125623126756349 0.412252675206357 1.52058526483743 0.206896551724138 22.1 22 1 abnormal spinal nerve morphology 0.125623126756349 0.412252675206357 1.52058526483743 0.206896551724138 22.1 22 1 absent long term depression 0.125623126756349 0.412252675206357 1.52058526483743 0.206896551724138 22.1 22 1 abnormal myocardial fiber morphology 0.0102886930661951 0.0973122585633477 1.51535988592046 0.206185567010309 22.1 22 1 abnormal oocyte morphology 0.104645147761106 0.394860429061833 1.51313141549999 0.205882352941176 22.1 22 1 thin skin 0.104645147761106 0.394860429061833 1.51313141549999 0.205882352941176 22.1 22 1 abnormal vision 0.104645147761106 0.394860429061833 1.51313141549999 0.205882352941176 22.1 22 1 decreased percent body fat/body weight 0.0247920911736054 0.168498160640283 1.51017029727005 0.205479452054795 22.1 22 1 reduced long term potentiation 0.00657023113374486 0.0720908997031511 1.50927138637882 0.205357142857143 22.1 22 1 abnormal leukocyte adhesion 0.0876659993660103 0.371814447438961 1.50758880958241 0.205128205128205 22.1 22 1 decreased trabecular bone volume 0.0876659993660103 0.371814447438961 1.50758880958241 0.205128205128205 22.1 22 1 hyperglycemia 0.0155972721168339 0.118926926072099 1.50330588682791 0.204545454545455 22.1 22 1 increased liver weight 0.0155972721168339 0.118926926072099 1.50330588682791 0.204545454545455 22.1 22 1 increased T cell number 0.0155972721168339 0.118926926072099 1.50330588682791 0.204545454545455 22.1 22 1 abnormal circadian rhythm 0.073769634592151 0.327389769933944 1.50330588682791 0.204545454545455 22.1 22 1 abnormal astrocyte morphology 0.073769634592151 0.327389769933944 1.50330588682791 0.204545454545455 22.1 22 1 decreased blood urea nitrogen level 0.073769634592151 0.327389769933944 1.50330588682791 0.204545454545455 22.1 22 1 decreased sensitivity to induced morbidity/mortality 0.073769634592151 0.327389769933944 1.50330588682791 0.204545454545455 22.1 22 1 improved glucose tolerance 0.000499792244534777 0.0107708636727623 1.49989702994168 0.204081632653061 22.1 22 1 abnormal long bone hypertrophic chondrocyte zone 0.0622999575001059 0.300622976297795 1.49989702994168 0.204081632653061 22.1 22 1 abnormal craniofacial morphology 0.00989753215157201 0.0942908355189541 1.498440819233 0.203883495145631 22.1 22 1 impaired limb coordination 0.052770406012503 0.27177305373934 1.4971194428492 0.203703703703704 22.1 22 1 abnormal colon morphology 0.044810607656213 0.238678793542726 1.49481263323002 0.203389830508475 22.1 22 1 increased B cell proliferation 0.044810607656213 0.238678793542726 1.49481263323002 0.203389830508475 22.1 22 1 increased hemoglobin content 0.044810607656213 0.238678793542726 1.49481263323002 0.203389830508475 22.1 22 1 limb grasping 0.000854263339082757 0.0162833720763859 1.49412819521114 0.203296703296703 22.1 22 1 decreased circulating LDL cholesterol level 0.0381329159481186 0.220066527552162 1.49286626261383 0.203125 22.1 22 1 decreased litter size 4.49707666694084e-05 0.00152196982435583 1.49082291979613 0.202846975088968 22.1 22 1 abnormal T cell activation 0.0277616305304877 0.177296677649777 1.48976259055019 0.202702702702703 22.1 22 1 increased food intake 0.0203270500847532 0.145716245204103 1.4873978880255 0.202380952380952 22.1 22 1 abnormal motor coordination/ balance 0.012840710245699 0.115103663914148 1.48474655489177 0.202020202020202 22.1 22 1 abnormal neuron morphology 0.012840710245699 0.115103663914148 1.48474655489177 0.202020202020202 22.1 22 1 abnormal immune system physiology 0.00606745867940857 0.0694007476937551 1.48175311425691 0.201612903225806 22.1 22 1 increased tumor incidence 0.00606745867940857 0.0694007476937551 1.48175311425691 0.201612903225806 22.1 22 1 increased heart weight 0.00389643021456448 0.0505448367069308 1.48047390293524 0.201438848920863 22.1 22 1 abnormal liver morphology 0.0012168278180378 0.020874891016338 1.47811081609896 0.201117318435754 22.1 22 1 male infertility 1.16121553014084e-07 9.62841210408448e-06 1.47574361852513 0.200795228628231 22.1 22 1 decreased circulating calcium level 0.0591141536656368 0.292365585050477 1.46989908934285 0.2 22.1 22 1 abnormal contextual conditioning behavior 0.0591141536656368 0.292365585050477 1.46989908934285 0.2 22.1 22 1 weight loss 0.00155855163496767 0.0251746570907927 1.46989908934285 0.2 22.1 22 1 impaired fertilization 0.036313597807727 0.215842472035176 1.46989908934285 0.2 22.1 22 1 abnormal kidney development 0.0501427721179822 0.260941727287616 1.46989908934285 0.2 22.1 22 1 increased body length 0.0698772350442857 0.325399434904965 1.46989908934285 0.2 22.1 22 1 kidney inflammation 0.0698772350442857 0.325399434904965 1.46989908934285 0.2 22.1 22 1 abnormal circulating protein level 0.0698772350442857 0.325399434904965 1.46989908934285 0.2 22.1 22 1 abnormal ectoderm development 0.0828638793782715 0.352951883481936 1.46989908934285 0.2 22.1 22 1 lethality at weaning, complete penetrance 0.0828638793782715 0.352951883481936 1.46989908934285 0.2 22.1 22 1 ovary cysts 0.118000903423556 0.394860429061833 1.46989908934285 0.2 22.1 22 1 perinatal lethality 0.0986457549394901 0.394860429061833 1.46989908934285 0.2 22.1 22 1 increased circulating serum albumin level 0.118000903423556 0.394860429061833 1.46989908934285 0.2 22.1 22 1 abnormal pancreatic beta cell morphology 0.0986457549394901 0.394860429061833 1.46989908934285 0.2 22.1 22 1 abnormal response to new environment 0.142028147455688 0.45063139897452 1.46989908934285 0.2 22.1 22 1 emphysema 0.142028147455688 0.45063139897452 1.46989908934285 0.2 22.1 22 1 abnormal microglial cell physiology 0.142028147455688 0.45063139897452 1.46989908934285 0.2 22.1 22 1 abnormal optic cup morphology 0.142028147455688 0.45063139897452 1.46989908934285 0.2 22.1 22 1 abnormal cochlear outer hair cell morphology 0.172360342360951 0.504704357413614 1.46989908934285 0.2 22.1 22 1 decreased placenta weight 0.172360342360951 0.504704357413614 1.46989908934285 0.2 22.1 22 1 abnormal energy expenditure 0.172360342360951 0.504704357413614 1.46989908934285 0.2 22.1 22 1 abnormal seminiferous tubule morphology 0.00413801306108664 0.0526511892043633 1.45983128736105 0.198630136986301 22.1 22 1 ataxia 0.000927508614550329 0.0170748018423649 1.45534563301272 0.198019801980198 22.1 22 1 abnormal pulmonary alveolus morphology 0.0158702254058951 0.119627835445952 1.45534563301272 0.198019801980198 22.1 22 1 increased thermal nociceptive threshold 0.0215708034359106 0.153306781562365 1.45374635209732 0.197802197802198 22.1 22 1 increased neuron apoptosis 0.0294484662265407 0.186675450793939 1.45175218700528 0.197530864197531 22.1 22 1 increased osteoclast cell number 0.0558908961542976 0.285479680048902 1.44580238296018 0.19672131147541 22.1 22 1 increased body weight 0.000636451915069435 0.0130609169029303 1.44365089131887 0.196428571428571 22.1 22 1 abnormal eye development 0.0659400178990998 0.317264592889769 1.44365089131887 0.196428571428571 22.1 22 1 hypoactivity 1.22809052369853e-05 0.00051923154578162 1.44260653330731 0.196286472148541 22.1 22 1 impaired balance 0.0175814231286377 0.131530195586425 1.44107753857142 0.196078431372549 22.1 22 1 abnormal immune system morphology 0.0926009271098031 0.390746066472663 1.43794476131366 0.195652173913043 22.1 22 1 abnormal retinal pigmentation 0.0279241280462487 0.178010433033342 1.4361083056798 0.195402298850575 22.1 22 1 abnormal excitatory postsynaptic potential 0.0326560901675129 0.201568298490542 1.4340478920418 0.195121951219512 22.1 22 1 scaly skin 0.110361846167006 0.394860429061833 1.4340478920418 0.195121951219512 22.1 22 1 decreased anxiety-related response 0.0106145555928308 0.0998701221744957 1.4340478920418 0.195121951219512 22.1 22 1 increased susceptibility to bacterial infection induced morbidity/mortality 0.0448572204949647 0.238678793542726 1.42906855908333 0.194444444444444 22.1 22 1 abnormal limb bone morphology 0.132190716875104 0.430645079416275 1.42906855908333 0.194444444444444 22.1 22 1 renal hypoplasia 0.132190716875104 0.430645079416275 1.42906855908333 0.194444444444444 22.1 22 1 abnormal trophoblast giant cell morphology 0.132190716875104 0.430645079416275 1.42906855908333 0.194444444444444 22.1 22 1 hyperactivity 2.36714528368244e-05 0.000933854805633865 1.42631717564266 0.194070080862534 22.1 22 1 increased total body fat amount 0.00868665195540255 0.0900335280794327 1.42602150458635 0.194029850746269 22.1 22 1 osteopetrosis 0.159357820056367 0.48165562258835 1.42248298968663 0.193548387096774 22.1 22 1 abnormal postnatal growth/weight/body size 0.159357820056367 0.48165562258835 1.42248298968663 0.193548387096774 22.1 22 1 inner cell mass degeneration 0.159357820056367 0.48165562258835 1.42248298968663 0.193548387096774 22.1 22 1 decreased double-negative T cell number 0.159357820056367 0.48165562258835 1.42248298968663 0.193548387096774 22.1 22 1 abnormal T cell proliferation 0.159357820056367 0.48165562258835 1.42248298968663 0.193548387096774 22.1 22 1 abnormal intestine physiology 0.159357820056367 0.48165562258835 1.42248298968663 0.193548387096774 22.1 22 1 small kidney 0.0308756287617424 0.194684731419098 1.41978889311525 0.193181818181818 22.1 22 1 abnormal blood homeostasis 0.015815033691166 0.11939270502815 1.41832368269924 0.192982456140351 22.1 22 1 incomplete embryo turning 0.0732555794700813 0.326272612232457 1.41832368269924 0.192982456140351 22.1 22 1 abnormal circulating amino acid level 0.0732555794700813 0.326272612232457 1.41832368269924 0.192982456140351 22.1 22 1 abnormal vertebrae morphology 0.0184028409199019 0.135836993436961 1.41595783835779 0.192660550458716 22.1 22 1 abnormal cornea morphology 0.0422966189108374 0.229722357075782 1.41336450898351 0.192307692307692 22.1 22 1 increased circulating alanine transaminase level 0.0422966189108374 0.229722357075782 1.41336450898351 0.192307692307692 22.1 22 1 abnormal leukocyte migration 0.0867083964306715 0.368381103537652 1.41336450898351 0.192307692307692 22.1 22 1 increased susceptibility to injury 0.0867083964306715 0.368381103537652 1.41336450898351 0.192307692307692 22.1 22 1 abnormal stomach morphology 0.193758185356628 0.554118076371095 1.41336450898351 0.192307692307692 22.1 22 1 abnormal erythrocyte osmotic lysis 0.193758185356628 0.554118076371095 1.41336450898351 0.192307692307692 22.1 22 1 deafness 0.0249823535661899 0.168734157651955 1.41050922714718 0.191919191919192 22.1 22 1 seminiferous tubule degeneration 0.0496184376220668 0.258483483947416 1.40949227745205 0.191780821917808 22.1 22 1 increased respiratory quotient 0.102977397735888 0.394860429061833 1.40735019192401 0.191489361702128 22.1 22 1 abnormal testis morphology 0.0174067529873807 0.130419572458161 1.40599043328447 0.191304347826087 22.1 22 1 lung inflammation 0.0105100709544275 0.0992174629948329 1.40505060010714 0.191176470588235 22.1 22 1 decreased susceptibility to injury 0.058312680421997 0.292365585050477 1.40505060010714 0.191176470588235 22.1 22 1 increased circulating HDL cholesterol level 0.0235852906919708 0.16373210991576 1.39990389461224 0.19047619047619 22.1 22 1 abnormal hair follicle morphology 0.0686721820282872 0.325332449455579 1.39990389461224 0.19047619047619 22.1 22 1 abnormal pancreas morphology 0.122799256506832 0.404586954385091 1.39990389461224 0.19047619047619 22.1 22 1 increased or absent threshold for auditory brainstem response 0.000337797762194081 0.00778029568016461 1.39869290508403 0.190311418685121 22.1 22 1 abnormal spermatogenesis 0.00371291328604587 0.0491269776544632 1.39800185127717 0.190217391304348 22.1 22 1 increased sensitivity to induced morbidity/mortality 0.00371291328604587 0.0491269776544632 1.39800185127717 0.190217391304348 22.1 22 1 decreased width of hypertrophic chondrocyte zone 0.147180465985818 0.465790596869876 1.39044508451351 0.189189189189189 22.1 22 1 abnormal pancreatic beta cell physiology 0.147180465985818 0.465790596869876 1.39044508451351 0.189189189189189 22.1 22 1 abnormal hair follicle development 0.147180465985818 0.465790596869876 1.39044508451351 0.189189189189189 22.1 22 1 decreased insulin secretion 0.037460771848714 0.220032278568303 1.3882380288238 0.188888888888889 22.1 22 1 abnormal pancreatic islet morphology 0.0959663936783026 0.394860429061833 1.38669725409703 0.188679245283019 22.1 22 1 cardiac fibrosis 0.0438074493237326 0.236173586574215 1.38343443702856 0.188235294117647 22.1 22 1 decreased startle reflex 0.0209646502634967 0.149211924264515 1.38195640878388 0.188034188034188 22.1 22 1 increased B cell number 0.0209646502634967 0.149211924264515 1.38195640878388 0.188034188034188 22.1 22 1 abnormal gait 0.000343024072770165 0.00786426157618235 1.3795169446907 0.187702265372168 22.1 22 1 abnormal urine homeostasis 0.0352065132670124 0.210519715749263 1.37803039625892 0.1875 22.1 22 1 abnormal kidney physiology 0.11398592687459 0.394860429061833 1.37803039625892 0.1875 22.1 22 1 failure of primitive streak formation 0.177546839644175 0.518061892803384 1.37803039625892 0.1875 22.1 22 1 increased dopamine level 0.177546839644175 0.518061892803384 1.37803039625892 0.1875 22.1 22 1 neonatal lethality 0.177546839644175 0.518061892803384 1.37803039625892 0.1875 22.1 22 1 abnormal depression-related behavior 0.177546839644175 0.518061892803384 1.37803039625892 0.1875 22.1 22 1 increased fatty acid level 0.177546839644175 0.518061892803384 1.37803039625892 0.1875 22.1 22 1 pancreatic islet hyperplasia 0.177546839644175 0.518061892803384 1.37803039625892 0.1875 22.1 22 1 decreased grip strength 0.00244443899016719 0.0355856743272855 1.37593293751271 0.187214611872146 22.1 22 1 reduced fertility 0.0138155356370314 0.115303738850336 1.3747257670113 0.18705035971223 22.1 22 1 abnormal organ of Corti morphology 0.135937936804548 0.43602341177224 1.36734799008637 0.186046511627907 22.1 22 1 thick epidermis 0.0706859354928365 0.325399434904965 1.36490629724693 0.185714285714286 22.1 22 1 dehydration 0.0706859354928365 0.325399434904965 1.36490629724693 0.185714285714286 22.1 22 1 abnormal cochlea morphology 0.105783663602348 0.394860429061833 1.36101767531745 0.185185185185185 22.1 22 1 abnormal trigeminal nerve morphology 0.216019223162245 0.555724858347875 1.36101767531745 0.185185185185185 22.1 22 1 wrinkled skin 0.216019223162245 0.555724858347875 1.36101767531745 0.185185185185185 22.1 22 1 abnormal skin appearance 0.216019223162245 0.555724858347875 1.36101767531745 0.185185185185185 22.1 22 1 decreased bone ossification 0.216019223162245 0.555724858347875 1.36101767531745 0.185185185185185 22.1 22 1 abnormal trabecular bone morphology 0.0250613049481471 0.168734157651955 1.35873025065305 0.184873949579832 22.1 22 1 small testis 0.00107866749980029 0.0190974050231547 1.35805894124068 0.184782608695652 22.1 22 1 decreased total retina thickness 0.162930049860597 0.486930218585225 1.35385442439473 0.184210526315789 22.1 22 1 short limbs 0.0526016495955842 0.271184670194851 1.35163134652216 0.183908045977011 22.1 22 1 increased circulating LDL cholesterol level 0.125615269983849 0.412252675206357 1.34990732694752 0.183673469387755 22.1 22 1 increased T cell derived lymphoma incidence 0.125615269983849 0.412252675206357 1.34990732694752 0.183673469387755 22.1 22 1 decreased urine osmolality 0.125615269983849 0.412252675206357 1.34990732694752 0.183673469387755 22.1 22 1 increased bone mineral content 0.0338818301925146 0.205313161032594 1.34853127462647 0.18348623853211 22.1 22 1 decreased liver weight 0.0774684228578354 0.341368825259283 1.34568226489134 0.183098591549296 22.1 22 1 abnormal developmental patterning 0.061551268683324 0.297298603591783 1.34441989878919 0.182926829268293 22.1 22 1 lethargy 0.0491665519964797 0.256437403308963 1.34345615692626 0.182795698924731 22.1 22 1 azoospermia 0.0136609367802629 0.115303738850336 1.34047401229379 0.182389937106918 22.1 22 1 impaired coordination 0.00045909853024182 0.0101062618935976 1.33820292815895 0.182080924855491 22.1 22 1 abnormal gametogenesis 0.149753115073969 0.47083387676354 1.33627189940259 0.181818181818182 22.1 22 1 omphalocele 0.149753115073969 0.47083387676354 1.33627189940259 0.181818181818182 22.1 22 1 abnormal photoreceptor outer segment morphology 0.149753115073969 0.47083387676354 1.33627189940259 0.181818181818182 22.1 22 1 abnormal tail morphology 0.091151009579355 0.386265990338408 1.33627189940259 0.181818181818182 22.1 22 1 abnormal skeleton physiology 0.196523699452534 0.554118076371095 1.33627189940259 0.181818181818182 22.1 22 1 abnormal T cell subpopulation ratio 0.196523699452534 0.554118076371095 1.33627189940259 0.181818181818182 22.1 22 1 head tossing 0.196523699452534 0.554118076371095 1.33627189940259 0.181818181818182 22.1 22 1 abnormal lipid level 0.0671627887534515 0.322835627099924 1.3282220686833 0.180722891566265 22.1 22 1 abnormal muscle physiology 0.0625535985014868 0.30126249036292 1.32125760839807 0.179775280898876 22.1 22 1 decreased rib number 0.0625535985014868 0.30126249036292 1.32125760839807 0.179775280898876 22.1 22 1 decreased compact bone thickness 0.0995382207150608 0.394860429061833 1.31632754269509 0.17910447761194 22.1 22 1 abnormal femur morphology 0.0995382207150608 0.394860429061833 1.31632754269509 0.17910447761194 22.1 22 1 short mandible 0.127070893617334 0.41645434502387 1.31240990119897 0.178571428571429 22.1 22 1 rib bifurcation 0.239023274939572 0.57950331034326 1.31240990119897 0.178571428571429 22.1 22 1 abnormal circulating cholesterol level 0.239023274939572 0.57950331034326 1.31240990119897 0.178571428571429 22.1 22 1 shortened head 0.239023274939572 0.57950331034326 1.31240990119897 0.178571428571429 22.1 22 1 small superior cervical ganglion 0.239023274939572 0.57950331034326 1.31240990119897 0.178571428571429 22.1 22 1 abnormal ovulation 0.239023274939572 0.57950331034326 1.31240990119897 0.178571428571429 22.1 22 1 increased bone resorption 0.239023274939572 0.57950331034326 1.31240990119897 0.178571428571429 22.1 22 1 abnormal rib morphology 0.0306346160946985 0.193410171410057 1.30657696830476 0.177777777777778 22.1 22 1 increased susceptibility to parasitic infection 0.0679790745345188 0.32291386673883 1.30657696830476 0.177777777777778 22.1 22 1 irregular heartbeat 0.164215652521687 0.486930218585225 1.30657696830476 0.177777777777778 22.1 22 1 increased circulating corticosterone level 0.164215652521687 0.486930218585225 1.30657696830476 0.177777777777778 22.1 22 1 decreased osteoclast cell number 0.164215652521687 0.486930218585225 1.30657696830476 0.177777777777778 22.1 22 1 cochlear inner hair cell degeneration 0.150672932687293 0.47083387676354 1.29696978471428 0.176470588235294 22.1 22 1 abnormal retinal photoreceptor morphology 0.216211960529268 0.555724858347875 1.29696978471428 0.176470588235294 22.1 22 1 abnormal bone remodeling 0.216211960529268 0.555724858347875 1.29696978471428 0.176470588235294 22.1 22 1 increased susceptibility to viral infection induced morbidity/mortality 0.216211960529268 0.555724858347875 1.29696978471428 0.176470588235294 22.1 22 1 decreased susceptibility to induced arthritis 0.138520960457174 0.440909647008601 1.28938516609022 0.175438596491228 22.1 22 1 decreased IgM level 0.0684827472325469 0.32478709960145 1.28805590303239 0.175257731958763 22.1 22 1 head bobbing 0.1965224894447 0.554118076371095 1.28616170317499 0.175 22.1 22 1 abnormal skin pigmentation 0.1965224894447 0.554118076371095 1.28616170317499 0.175 22.1 22 1 increased susceptibility to weight loss 0.1965224894447 0.554118076371095 1.28616170317499 0.175 22.1 22 1 abnormal motor capabilities/coordination/movement 0.0413098240251029 0.225653773486521 1.28059390359415 0.174242424242424 22.1 22 1 abnormal brain morphology 0.0271771790532117 0.174010895482276 1.2781731211677 0.173913043478261 22.1 22 1 cachexia 0.0687285234930279 0.325332449455579 1.27202805808516 0.173076923076923 22.1 22 1 absent corpus luteum 0.164060858880539 0.486930218585225 1.27202805808516 0.173076923076923 22.1 22 1 decreased IgA level 0.164060858880539 0.486930218585225 1.27202805808516 0.173076923076923 22.1 22 1 decreased kidney weight 0.164060858880539 0.486930218585225 1.27202805808516 0.173076923076923 22.1 22 1 decreased body temperature 0.164060858880539 0.486930218585225 1.27202805808516 0.173076923076923 22.1 22 1 female infertility 0.00668018186194024 0.0720908997031511 1.27096537800322 0.172932330827068 22.1 22 1 increased exploration in new environment 0.10044537752833 0.394860429061833 1.27028316362962 0.172839506172839 22.1 22 1 dermatitis 0.150490712654183 0.47083387676354 1.26715438736453 0.172413793103448 22.1 22 1 abnormal enzyme/coenzyme level 0.150490712654183 0.47083387676354 1.26715438736453 0.172413793103448 22.1 22 1 abnormal circulating glucose level 0.262648305811077 0.619076930245449 1.26715438736453 0.172413793103448 22.1 22 1 enlarged epididymis 0.262648305811077 0.619076930245449 1.26715438736453 0.172413793103448 22.1 22 1 increased double-positive T cell number 0.262648305811077 0.619076930245449 1.26715438736453 0.172413793103448 22.1 22 1 decreased caudal vertebrae number 0.138326082102008 0.44057122820582 1.26319452990401 0.171875 22.1 22 1 holoprosencephaly 0.236531489585623 0.577684909518151 1.25991350515101 0.171428571428571 22.1 22 1 abnormal response/metabolism to endogenous compounds 0.10845298817289 0.394860429061833 1.25479190553658 0.170731707317073 22.1 22 1 increased cellular sensitivity to gamma-irradiation 0.194946803810318 0.554118076371095 1.25097794837689 0.170212765957447 22.1 22 1 abnormal innervation 0.194946803810318 0.554118076371095 1.25097794837689 0.170212765957447 22.1 22 1 syndactyly 0.162963365914551 0.486930218585225 1.24567719435835 0.169491525423729 22.1 22 1 polyuria 0.126659661394106 0.4153802343017 1.24082390658812 0.168831168831169 22.1 22 1 infertility 0.0855435200544592 0.364053902712519 1.236363720008 0.168224299065421 22.1 22 1 increased bone mineral density 0.0793111307755578 0.349179535936637 1.23575587157142 0.168141592920354 22.1 22 1 abnormal lymph node morphology 0.211138979197464 0.555724858347875 1.22491590778571 0.166666666666667 22.1 22 1 abnormal neuromuscular synapse morphology 0.148088010295969 0.46777006426822 1.22491590778571 0.166666666666667 22.1 22 1 abnormal digit morphology 0.148088010295969 0.46777006426822 1.22491590778571 0.166666666666667 22.1 22 1 cochlear outer hair cell degeneration 0.148088010295969 0.46777006426822 1.22491590778571 0.166666666666667 22.1 22 1 abnormal skin morphology 0.161233486043505 0.484382000643983 1.22491590778571 0.166666666666667 22.1 22 1 abnormal long bone epiphyseal plate proliferative zone 0.192430393940363 0.554118076371095 1.22491590778571 0.166666666666667 22.1 22 1 disheveled coat 0.232553883194998 0.568528535083594 1.22491590778571 0.166666666666667 22.1 22 1 abnormal lysosome morphology 0.257399644127727 0.608922125314046 1.22491590778571 0.166666666666667 22.1 22 1 abnormal heart tube morphology 0.286772337482154 0.665278469539269 1.22491590778571 0.166666666666667 22.1 22 1 increased metastatic potential 0.286772337482154 0.665278469539269 1.22491590778571 0.166666666666667 22.1 22 1 arrested T cell differentiation 0.286772337482154 0.665278469539269 1.22491590778571 0.166666666666667 22.1 22 1 salivary gland inflammation 0.286772337482154 0.665278469539269 1.22491590778571 0.166666666666667 22.1 22 1 enhanced paired-pulse facilitation 0.286772337482154 0.665278469539269 1.22491590778571 0.166666666666667 22.1 22 1 decreased food intake 0.146250826387327 0.46373349985784 1.20941064313019 0.164556962025316 22.1 22 1 abnormal T-helper 2 physiology 0.20735390596577 0.555724858347875 1.20264470946233 0.163636363636364 22.1 22 1 organ of Corti degeneration 0.227826532214755 0.561385338171573 1.19991762395335 0.163265306122449 22.1 22 1 increased sarcoma incidence 0.227826532214755 0.561385338171573 1.19991762395335 0.163265306122449 22.1 22 1 increased fluid intake 0.227826532214755 0.561385338171573 1.19991762395335 0.163265306122449 22.1 22 1 abnormal social investigation 0.156620066017833 0.475112700267511 1.19429301009107 0.1625 22.1 22 1 abnormal long bone metaphysis morphology 0.278732388284225 0.648593840839111 1.19181007244015 0.162162162162162 22.1 22 1 impaired skeletal muscle contractility 0.278732388284225 0.648593840839111 1.19181007244015 0.162162162162162 22.1 22 1 increased insulin secretion 0.278732388284225 0.648593840839111 1.19181007244015 0.162162162162162 22.1 22 1 decreased circulating glucose level 0.0233636869913184 0.16373210991576 1.18540249140552 0.161290322580645 22.1 22 1 increased lung adenoma incidence 0.311275129294806 0.665278469539269 1.18540249140552 0.161290322580645 22.1 22 1 abnormal CD8-positive, alpha beta T cell morphology 0.311275129294806 0.665278469539269 1.18540249140552 0.161290322580645 22.1 22 1 decreased susceptibility to bacterial infection induced morbidity/mortality 0.311275129294806 0.665278469539269 1.18540249140552 0.161290322580645 22.1 22 1 enlarged liver 0.139450204277017 0.443583610152275 1.17591927147428 0.16 22.1 22 1 abnormal epidermal layer morphology 0.198834648801417 0.554118076371095 1.17165869440372 0.159420289855072 22.1 22 1 abnormal amino acid level 0.270559517620491 0.630460702651965 1.16923791197727 0.159090909090909 22.1 22 1 decreased neuron apoptosis 0.300445326738655 0.665278469539269 1.1604466494812 0.157894736842105 22.1 22 1 impaired branching involved in ureteric bud morphogenesis 0.300445326738655 0.665278469539269 1.1604466494812 0.157894736842105 22.1 22 1 hyporesponsive to tactile stimuli 0.300445326738655 0.665278469539269 1.1604466494812 0.157894736842105 22.1 22 1 abnormal eye electrophysiology 0.131809305676261 0.430645079416275 1.15405300402951 0.15702479338843 22.1 22 1 short tail 0.18990264577678 0.549282362057837 1.15112579285886 0.156626506024096 22.1 22 1 abnormal lens morphology 0.129211691088786 0.423191680820745 1.1483586635491 0.15625 22.1 22 1 decreased eosinophil cell number 0.23211979588103 0.567746305067908 1.1483586635491 0.15625 22.1 22 1 increased sacral vertebrae number 0.23211979588103 0.567746305067908 1.1483586635491 0.15625 22.1 22 1 polydipsia 0.336039627378256 0.694845031673658 1.1483586635491 0.15625 22.1 22 1 increased circulating follicle stimulating hormone level 0.336039627378256 0.694845031673658 1.1483586635491 0.15625 22.1 22 1 abnormal lumbar vertebrae morphology 0.336039627378256 0.694845031673658 1.1483586635491 0.15625 22.1 22 1 abnormal serotonin level 0.336039627378256 0.694845031673658 1.1483586635491 0.15625 22.1 22 1 abnormal ovarian follicle morphology 0.290149176980798 0.665278469539269 1.14325484726666 0.155555555555556 22.1 22 1 cardiomyopathy 0.290149176980798 0.665278469539269 1.14325484726666 0.155555555555556 22.1 22 1 abnormal female meiosis 0.280406904884191 0.652185297708672 1.13069160718681 0.153846153846154 22.1 22 1 abnormal circulating hormone level 0.322454647799086 0.672100058096201 1.13069160718681 0.153846153846154 22.1 22 1 abnormal forelimb morphology 0.310046540599595 0.665278469539269 1.11840148102173 0.152173913043478 22.1 22 1 hunched posture 0.232882995060364 0.569053487438757 1.1163790551971 0.151898734177215 22.1 22 1 abnormal CNS synaptic transmission 0.202431393880806 0.555724858347875 1.11355991616883 0.151515151515152 22.1 22 1 impaired swimming 0.262470934619493 0.619076930245449 1.11355991616883 0.151515151515152 22.1 22 1 diarrhea 0.360953185936421 0.733192575603473 1.11355991616883 0.151515151515152 22.1 22 1 abnormal middle ear ossicle morphology 0.360953185936421 0.733192575603473 1.11355991616883 0.151515151515152 22.1 22 1 cardiovascular system phenotype 0.360953185936421 0.733192575603473 1.11355991616883 0.151515151515152 22.1 22 1 abnormal long bone epiphyseal plate morphology 0.288006538356517 0.665278469539269 1.10242431700714 0.15 22.1 22 1 impaired ovarian folliculogenesis 0.344677969861624 0.702487873847432 1.10242431700714 0.15 22.1 22 1 abnormal tibia morphology 0.330188994537718 0.687605796494411 1.09460570482978 0.148936170212766 22.1 22 1 axon degeneration 0.317081282300543 0.665278469539269 1.08881414025396 0.148148148148148 22.1 22 1 abnormal male meiosis 0.305083777095957 0.665278469539269 1.08435178722014 0.147540983606557 22.1 22 1 impaired synaptic plasticity 0.385908569627308 0.759843641299906 1.08080815392857 0.147058823529412 22.1 22 1 decreased pancreatic beta cell number 0.385908569627308 0.759843641299906 1.08080815392857 0.147058823529412 22.1 22 1 decreased cytotoxic T cell cytolysis 0.385908569627308 0.759843641299906 1.08080815392857 0.147058823529412 22.1 22 1 increased susceptibility to weight gain 0.385908569627308 0.759843641299906 1.08080815392857 0.147058823529412 22.1 22 1 thick ventricular wall 0.367035088338422 0.742699770338142 1.07553591903135 0.146341463414634 22.1 22 1 increased startle reflex 0.265019630904405 0.620067897307709 1.07352180682343 0.146067415730337 22.1 22 1 abnormal hair shaft morphology 0.350514606912884 0.713798677606057 1.07180141931249 0.145833333333333 22.1 22 1 abnormal phalanx morphology 0.350514606912884 0.713798677606057 1.07180141931249 0.145833333333333 22.1 22 1 abnormal joint morphology 0.335758282527738 0.694845031673658 1.06901751952207 0.145454545454545 22.1 22 1 embryonic lethality before implantation, complete penetrance 0.237016286177655 0.578584898789909 1.05832734432685 0.144 22.1 22 1 abnormal neuron differentiation 0.263970686269594 0.619076930245449 1.04992792095918 0.142857142857143 22.1 22 1 arrest of spermatogenesis 0.302729933217989 0.665278469539269 1.04992792095918 0.142857142857143 22.1 22 1 abnormal vibrissa morphology 0.389448622528992 0.759843641299906 1.04992792095918 0.142857142857143 22.1 22 1 spina bifida 0.389448622528992 0.759843641299906 1.04992792095918 0.142857142857143 22.1 22 1 skin lesions 0.339872525693072 0.694924197187825 1.04992792095918 0.142857142857143 22.1 22 1 increased circulating aspartate transaminase level 0.339872525693072 0.694924197187825 1.04992792095918 0.142857142857143 22.1 22 1 circling 0.317352261051763 0.665278469539269 1.03757582777142 0.141176470588235 22.1 22 1 abnormal excitatory postsynaptic currents 0.329642295050785 0.686754781355803 1.03646730658791 0.141025641025641 22.1 22 1 impaired natural killer cell mediated cytotoxicity 0.373548765355476 0.753916879368558 1.03150813287218 0.140350877192982 22.1 22 1 abnormal homeostasis 0.411844563931203 0.776385053136291 1.02551099256478 0.13953488372093 22.1 22 1 abnormal posture 0.361069710598695 0.733192575603473 1.01055562392321 0.1375 22.1 22 1 increased lung adenocarcinoma incidence 0.411991264377851 0.776385053136291 1.008754277 0.137254901960784 22.1 22 1 abnormal response to novel object 0.411991264377851 0.776385053136291 1.008754277 0.137254901960784 22.1 22 1 teratozoospermia 0.362100313858873 0.734985337188042 1.00220392455194 0.136363636363636 22.1 22 1 decreased macrophage cell number 0.434152729138157 0.811458359203268 1.00220392455194 0.136363636363636 22.1 22 1 cochlear hair cell degeneration 0.434152729138157 0.811458359203268 1.00220392455194 0.136363636363636 22.1 22 1 increased white adipose tissue amount 0.460049871134219 0.839632516575412 0.993175060366791 0.135135135135135 22.1 22 1 decreased circulating chloride level 0.460049871134219 0.839632516575412 0.993175060366791 0.135135135135135 22.1 22 1 abnormal chromosome morphology 0.460049871134219 0.839632516575412 0.993175060366791 0.135135135135135 22.1 22 1 abnormal humerus morphology 0.460049871134219 0.839632516575412 0.993175060366791 0.135135135135135 22.1 22 1 increased trabecular bone volume 0.460049871134219 0.839632516575412 0.993175060366791 0.135135135135135 22.1 22 1 abnormal spatial learning 0.308010846681171 0.665278469539269 0.991956440660819 0.134969325153374 22.1 22 1 maternal effect 0.41088553039246 0.775182219834087 0.987245657021317 0.134328358208955 22.1 22 1 abnormal eye physiology 0.430621485994597 0.806604628321958 0.979932726228567 0.133333333333333 22.1 22 1 increased grooming behavior 0.48423237786082 0.858537448274261 0.967038874567665 0.131578947368421 22.1 22 1 decreased threshold for auditory brainstem response 0.48423237786082 0.858537448274261 0.967038874567665 0.131578947368421 22.1 22 1 abnormal inner ear morphology 0.478246208954474 0.848831569585626 0.958629840875772 0.130434782608696 22.1 22 1 abnormal sleep pattern 0.478246208954474 0.848831569585626 0.958629840875772 0.130434782608696 22.1 22 1 abnormal coat appearance 0.446501748620032 0.830099476601143 0.958629840875772 0.130434782608696 22.1 22 1 increased anxiety-related response 0.399640967605374 0.759843641299906 0.951733223315514 0.129496402877698 22.1 22 1 increased eosinophil cell number 0.468412782313314 0.839632516575412 0.948321993124419 0.129032258064516 22.1 22 1 abnormal action potential 0.464212153490417 0.839632516575412 0.944935128863261 0.128571428571429 22.1 22 1 abnormal lens fiber morphology 0.508023220516957 0.896246639032574 0.942243005989007 0.128205128205128 22.1 22 1 increased autoantibody level 0.508023220516957 0.896246639032574 0.942243005989007 0.128205128205128 22.1 22 1 increased susceptibility to pharmacologically induced seizures 0.483711226569001 0.858225161262761 0.918686930839281 0.125 22.1 22 1 oligodactyly 0.521255762876807 0.908214117236414 0.918686930839281 0.125 22.1 22 1 abnormal female reproductive system morphology 0.531358256324861 0.908214117236414 0.918686930839281 0.125 22.1 22 1 palatal shelves fail to meet at midline 0.5541809185452 0.936179989732554 0.896279932526128 0.121951219512195 22.1 22 1 abnormal digestive system physiology 0.562784128147088 0.949745942174953 0.88193945360571 0.12 22.1 22 1 abnormal spleen white pulp morphology 0.576442039628472 0.967803298692057 0.874939934132649 0.119047619047619 22.1 22 1 abnormal food intake 0.594365067211126 0.973326599531057 0.852115414111797 0.115942028985507 22.1 22 1 increased percent body fat/body weight 0.602511134724364 0.98634185431185 0.848018705390106 0.115384615384615 22.1 22 1 abnormal coat/ hair morphology 0.621619654516777 1 0.832018352458217 0.113207547169811 22.1 22 1 polyphagia 0.640191450621743 1 0.816610605190472 0.111111111111111 22.1 22 1 abnormal autopod morphology 0.639469845893131 1 0.816610605190472 0.111111111111111 22.1 22 1 abnormal nervous system electrophysiology 0.688964636369448 1 0.787445940719384 0.107142857142857 22.1 22 1 enhanced long term potentiation 0.675649867238337 1 0.787445940719384 0.107142857142857 22.1 22 1 impaired righting response 0.714779388402475 1 0.773631099654132 0.105263157894737 22.1 22 1 short femur 0.741124782276567 1 0.751652943413957 0.102272727272727 22.1 22 1 abnormal thoracic vertebrae morphology 0.724443153049253 1 0.747406316615008 0.101694915254237 22.1 22 1 abnormal brain wave pattern 0.762009356116332 1 0.706682254491755 0.0961538461538462 22.1 22 1 obese 0.911623806268198 1 0.572687956886825 0.0779220779220779 22.1 22 1 abnormal inhibitory postsynaptic currents 0.921991561866318 1 0.540404076964283 0.0735294117647059 22.1 22 1 decreased inflammatory response 0.946550837447172 1 0.524963960479589 0.0714285714285714 22.1 22 1 abnormal inflammatory response 0.9426496877434 1 0.510381628244045 0.0694444444444444 22.1 22 1 abnormal tumor incidence 2.98081991115297e-05 0.000956747035999097 3.42987725254636 1 22.4 22 4 gastric polyps 0.000585601714559674 0.010662809206643 3.42987725254636 1 22.4 22 4 ischuria 0.000585601714559674 0.010662809206643 3.42987725254636 1 22.4 22 4 decreased DN3 thymocyte number 0.000585601714559674 0.010662809206643 3.42987725254636 1 22.4 22 4 increased T follicular helper cell number 0.000585601714559674 0.010662809206643 3.42987725254636 1 22.4 22 4 decreased level of surface class I molecules 4.83838047795828e-05 0.00138338752171508 3.04877978004121 0.888888888888889 22.4 22 4 decreased tidal volume 0.000746038610120947 0.0128872989074712 2.93989478789688 0.857142857142857 22.4 22 4 abnormal retina inner limiting membrane morphology 0.000746038610120947 0.0128872989074712 2.93989478789688 0.857142857142857 22.4 22 4 abnormal vascular endothelial cell development 1.42761302584061e-05 0.000528184758244622 2.85823104378863 0.833333333333333 22.4 22 4 abnormal hippocampal fimbria morphology 0.00285297614107938 0.0365813306749225 2.85823104378863 0.833333333333333 22.4 22 4 cerebral arteriovenous malformation 0.00285297614107938 0.0365813306749225 2.85823104378863 0.833333333333333 22.4 22 4 delayed limb development 0.00285297614107938 0.0365813306749225 2.85823104378863 0.833333333333333 22.4 22 4 abnormal sphenoid bone morphology 5.30242983289983e-05 0.00150740505249581 2.80626320662884 0.818181818181818 22.4 22 4 decreased transitional stage T2 B cell number 0.00019356618322504 0.004458295192336 2.74390180203709 0.8 22.4 22 4 decreased transitional stage T1 B cell number 0.000691941557358029 0.0121639902751102 2.66768230753606 0.777777777777778 22.4 22 4 colon polyps 0.00240996452442608 0.0326691376267568 2.57240793940977 0.75 22.4 22 4 binucleate 0.00240996452442608 0.0326691376267568 2.57240793940977 0.75 22.4 22 4 delayed suture closure 0.00240996452442608 0.0326691376267568 2.57240793940977 0.75 22.4 22 4 increased aorta wall thickness 0.00240996452442608 0.0326691376267568 2.57240793940977 0.75 22.4 22 4 abnormal proximal-distal axis patterning 0.000568344542947819 0.010589940453803 2.49445618367008 0.727272727272727 22.4 22 4 abnormal dorsal-ventral polarity of the somites 0.000568344542947819 0.010589940453803 2.49445618367008 0.727272727272727 22.4 22 4 increased hemangioma incidence 0.000137228688729629 0.0032822727232207 2.4499123232474 0.714285714285714 22.4 22 4 asymmetric rib joints 0.00812031996847547 0.0795215143760735 2.4499123232474 0.714285714285714 22.4 22 4 broad head 0.00812031996847547 0.0795215143760735 2.4499123232474 0.714285714285714 22.4 22 4 mammary gland hyperplasia 0.00812031996847547 0.0795215143760735 2.4499123232474 0.714285714285714 22.4 22 4 decreased activated T cell number 0.00812031996847547 0.0795215143760735 2.4499123232474 0.714285714285714 22.4 22 4 decreased mortality induced by ionizing radiation 0.00812031996847547 0.0795215143760735 2.4499123232474 0.714285714285714 22.4 22 4 increased keratinocyte apoptosis 0.00812031996847547 0.0795215143760735 2.4499123232474 0.714285714285714 22.4 22 4 abnormal sperm annulus morphology 0.00812031996847547 0.0795215143760735 2.4499123232474 0.714285714285714 22.4 22 4 abnormal conotruncal ridge morphology 0.00812031996847547 0.0795215143760735 2.4499123232474 0.714285714285714 22.4 22 4 increased right ventricle systolic pressure 0.00812031996847547 0.0795215143760735 2.4499123232474 0.714285714285714 22.4 22 4 absent connection between subcutaneous lymph vessels and lymph sac 0.00812031996847547 0.0795215143760735 2.4499123232474 0.714285714285714 22.4 22 4 abnormal developmental vascular remodeling 0.00185481743033501 0.0279442079527094 2.40091407678245 0.7 22.4 22 4 abnormal mitral valve morphology 8.01246119866828e-05 0.00213165745793448 2.2865848350309 0.666666666666667 22.4 22 4 increased effector memory CD8-positive, alpha-beta T cell number 8.01246119866828e-05 0.00213165745793448 2.2865848350309 0.666666666666667 22.4 22 4 abnormal placenta size 0.00032804151307961 0.00677181131772224 2.2865848350309 0.666666666666667 22.4 22 4 myocarditis 0.00136649602376191 0.021581961010208 2.2865848350309 0.666666666666667 22.4 22 4 loss of dopaminergic neurons 0.00136649602376191 0.021581961010208 2.2865848350309 0.666666666666667 22.4 22 4 pale placenta 0.00136649602376191 0.021581961010208 2.2865848350309 0.666666666666667 22.4 22 4 decreased mammary gland epithelial cell proliferation 0.00136649602376191 0.021581961010208 2.2865848350309 0.666666666666667 22.4 22 4 abnormal lens capsule morphology 0.00584601045856218 0.0642028742413837 2.2865848350309 0.666666666666667 22.4 22 4 decreased fear-related response 0.00584601045856218 0.0642028742413837 2.2865848350309 0.666666666666667 22.4 22 4 decreased cellular sensitivity to ionizing radiation 0.00584601045856218 0.0642028742413837 2.2865848350309 0.666666666666667 22.4 22 4 increased neuronal precursor cell number 0.00584601045856218 0.0642028742413837 2.2865848350309 0.666666666666667 22.4 22 4 increased mammary adenocarcinoma incidence 5.91839302672826e-05 0.00167295484704392 2.22942021415513 0.65 22.4 22 4 abnormal embryonic-extraembryonic boundary morphology 0.000239701916537788 0.00525337900782156 2.21933233988294 0.647058823529412 22.4 22 4 megacephaly 0.000983151407216734 0.0161959544731896 2.20492109092266 0.642857142857143 22.4 22 4 increased stomach tumor incidence 0.000983151407216734 0.0161959544731896 2.20492109092266 0.642857142857143 22.4 22 4 abnormal vascular branching morphogenesis 4.31162189749765e-05 0.00127680469881255 2.18264916071132 0.636363636363636 22.4 22 4 delayed hepatic development 0.00410614498326258 0.0495975055327049 2.18264916071132 0.636363636363636 22.4 22 4 pathological neovascularization 0.00410614498326258 0.0495975055327049 2.18264916071132 0.636363636363636 22.4 22 4 abnormal aorta smooth muscle morphology 0.00410614498326258 0.0495975055327049 2.18264916071132 0.636363636363636 22.4 22 4 reduced sympathetic cervical ganglion size 0.00410614498326258 0.0495975055327049 2.18264916071132 0.636363636363636 22.4 22 4 increased red blood cell distribution width 3.74536601943971e-07 2.19214069961324e-05 2.15592284445771 0.628571428571429 22.4 22 4 increased fibroblast apoptosis 1.45861409271504e-06 7.40469909311974e-05 2.14367328284147 0.625 22.4 22 4 decreased mast cell number 0.000697481453822103 0.0122182050449471 2.14367328284147 0.625 22.4 22 4 abnormal cecum morphology 0.0176375790418911 0.1339648179136 2.14367328284147 0.625 22.4 22 4 abnormal eyelid aperture 0.0176375790418911 0.1339648179136 2.14367328284147 0.625 22.4 22 4 elevated level of mitotic sister chromatid exchange 0.0176375790418911 0.1339648179136 2.14367328284147 0.625 22.4 22 4 abnormal extraembryonic tissue physiology 0.0176375790418911 0.1339648179136 2.14367328284147 0.625 22.4 22 4 abnormal kidney epithelium morphology 0.0176375790418911 0.1339648179136 2.14367328284147 0.625 22.4 22 4 accumulation of giant lysosomes in kidney/renal tubule cells 0.0176375790418911 0.1339648179136 2.14367328284147 0.625 22.4 22 4 abnormal NK cell morphology 0.0176375790418911 0.1339648179136 2.14367328284147 0.625 22.4 22 4 abnormal olfactory bulb mitral cell layer morphology 0.0176375790418911 0.1339648179136 2.14367328284147 0.625 22.4 22 4 decreased hippocampus pyramidal cell number 0.0176375790418911 0.1339648179136 2.14367328284147 0.625 22.4 22 4 myocardial trabeculae hypoplasia 0.0176375790418911 0.1339648179136 2.14367328284147 0.625 22.4 22 4 abnormal anterior commissure pars posterior morphology 0.0176375790418911 0.1339648179136 2.14367328284147 0.625 22.4 22 4 increased testis apoptosis 0.0176375790418911 0.1339648179136 2.14367328284147 0.625 22.4 22 4 liver hypoplasia 1.82758071903447e-09 1.8184428154393e-07 2.11069369387468 0.615384615384615 22.4 22 4 decreased cellular sensitivity to gamma-irradiation 0.000490466252260952 0.00933244679367617 2.09603609877833 0.611111111111111 22.4 22 4 lymphoid hyperplasia 1.58373143191563e-05 0.000562790276698591 2.08242547476029 0.607142857142857 22.4 22 4 abnormal cell morphology 3.26993073542515e-18 1.01674408804626e-15 2.07597833706753 0.605263157894737 22.4 22 4 abnormal vascular regression 0.000342901950496395 0.00699154591688347 2.05792635152781 0.6 22.4 22 4 anencephaly 0.000342901950496395 0.00699154591688347 2.05792635152781 0.6 22.4 22 4 absent ductus venosus valve 0.000342901950496395 0.00699154591688347 2.05792635152781 0.6 22.4 22 4 absent egg cylinders 0.00196581624842242 0.0288773297663316 2.05792635152781 0.6 22.4 22 4 immune system phenotype 0.00196581624842242 0.0288773297663316 2.05792635152781 0.6 22.4 22 4 retarded hair growth 0.0118328000009029 0.0999459762385264 2.05792635152781 0.6 22.4 22 4 fused cornea and lens 0.0118328000009029 0.0999459762385264 2.05792635152781 0.6 22.4 22 4 abnormal tibialis anterior morphology 0.0118328000009029 0.0999459762385264 2.05792635152781 0.6 22.4 22 4 acrania 0.0118328000009029 0.0999459762385264 2.05792635152781 0.6 22.4 22 4 lymphedema 0.0118328000009029 0.0999459762385264 2.05792635152781 0.6 22.4 22 4 abnormal gas homeostasis 0.0118328000009029 0.0999459762385264 2.05792635152781 0.6 22.4 22 4 abnormal cerebellar granule cell migration 0.0118328000009029 0.0999459762385264 2.05792635152781 0.6 22.4 22 4 thin ventricle myocardium compact layer 0.0118328000009029 0.0999459762385264 2.05792635152781 0.6 22.4 22 4 fusion of atlas and odontoid process 0.0118328000009029 0.0999459762385264 2.05792635152781 0.6 22.4 22 4 abnormal adaptive thermogenesis 0.0118328000009029 0.0999459762385264 2.05792635152781 0.6 22.4 22 4 decreased circulating lactate level 0.0118328000009029 0.0999459762385264 2.05792635152781 0.6 22.4 22 4 abnormal liver development 2.07225677641892e-06 9.91295909873474e-05 2.05792635152781 0.6 22.4 22 4 increased skin papilloma incidence 0.000238797779522323 0.00525337900782156 2.02674564923194 0.590909090909091 22.4 22 4 increased myocardial infarction size 0.000238797779522323 0.00525337900782156 2.02674564923194 0.590909090909091 22.4 22 4 increased adenoma incidence 0.000238797779522323 0.00525337900782156 2.02674564923194 0.590909090909091 22.4 22 4 increased mortality induced by gamma-irradiation 3.02106468276929e-05 0.000963448512613925 2.01061769976855 0.586206896551724 22.4 22 4 mesocardia 0.00794165352656351 0.0794964311763651 2.00076173065204 0.583333333333333 22.4 22 4 altered tumor susceptibility 0.00794165352656351 0.0794964311763651 2.00076173065204 0.583333333333333 22.4 22 4 decreased synaptic depression 0.00794165352656351 0.0794964311763651 2.00076173065204 0.583333333333333 22.4 22 4 decreased red blood cell distribution width 0.00794165352656351 0.0794964311763651 2.00076173065204 0.583333333333333 22.4 22 4 prenatal growth retardation 0.00794165352656351 0.0794964311763651 2.00076173065204 0.583333333333333 22.4 22 4 embryonic lethality between implantation and placentation, incomplete penetrance 0.00794165352656351 0.0794964311763651 2.00076173065204 0.583333333333333 22.4 22 4 preaxial polydactyly 2.10991702736571e-05 0.000709245757509758 1.99154163051079 0.580645161290323 22.4 22 4 pale yolk sac 4.37857039346783e-12 6.60102657803105e-10 1.98354347135211 0.578313253012048 22.4 22 4 abnormal aorta morphology 1.47099554204373e-05 0.000538103148652025 1.97477781207215 0.575757575757576 22.4 22 4 abnormal apoptosis 3.3844367451808e-08 2.59039581650377e-06 1.96900360794328 0.574074074074074 22.4 22 4 pericardial edema 6.13908547342457e-10 6.49828728303983e-08 1.96713548307806 0.573529411764706 22.4 22 4 increased lactate dehydrogenase level 0.00533898993862651 0.0603669885106066 1.95992985859792 0.571428571428571 22.4 22 4 failure of zygotic cell division 0.00533898993862651 0.0603669885106066 1.95992985859792 0.571428571428571 22.4 22 4 vascular smooth muscle hypoplasia 0.00533898993862651 0.0603669885106066 1.95992985859792 0.571428571428571 22.4 22 4 lysosomal protein accumulation 0.00533898993862651 0.0603669885106066 1.95992985859792 0.571428571428571 22.4 22 4 multiple persisting craniopharyngeal ducts 0.00533898993862651 0.0603669885106066 1.95992985859792 0.571428571428571 22.4 22 4 decreased response to antigen 0.00533898993862651 0.0603669885106066 1.95992985859792 0.571428571428571 22.4 22 4 abnormal nasal cavity morphology 0.000435819015905993 0.00846952970364186 1.93862627317838 0.565217391304348 22.4 22 4 abnormal cardiovascular development 0.000435819015905993 0.00846952970364186 1.93862627317838 0.565217391304348 22.4 22 4 abnormal vitelline vasculature morphology 3.52771246644009e-15 7.9774406911543e-13 1.93862627317838 0.565217391304348 22.4 22 4 overriding aortic valve 4.54954978621241e-07 2.63186164958218e-05 1.92930595455733 0.5625 22.4 22 4 abnormal erythropoiesis 9.25704981119067e-14 1.91890928377807e-11 1.92726436095462 0.561904761904762 22.4 22 4 abnormal vascular development 3.99587222395905e-09 3.61444805712659e-07 1.92280997491235 0.560606060606061 22.4 22 4 increased cellular sensitivity to ionizing radiation 0.000298684421182732 0.00632321274631529 1.92073126142596 0.56 22.4 22 4 abnormal cell cycle 1.56758620642714e-14 3.39075712042393e-12 1.90880125359102 0.556521739130435 22.4 22 4 abnormal bile duct morphology 0.00242768468275884 0.0327309791239166 1.90548736252575 0.555555555555556 22.4 22 4 decreased tumor latency 0.00242768468275884 0.0327309791239166 1.90548736252575 0.555555555555556 22.4 22 4 multifocal hepatic necrosis 0.0323770397710523 0.204014094416122 1.90548736252575 0.555555555555556 22.4 22 4 increased pheochromocytoma incidence 0.0323770397710523 0.204014094416122 1.90548736252575 0.555555555555556 22.4 22 4 abnormal thymus lobule morphology 0.0323770397710523 0.204014094416122 1.90548736252575 0.555555555555556 22.4 22 4 abnormal thymus physiology 0.0323770397710523 0.204014094416122 1.90548736252575 0.555555555555556 22.4 22 4 short frontal bone 0.0323770397710523 0.204014094416122 1.90548736252575 0.555555555555556 22.4 22 4 liver hyperplasia 0.0323770397710523 0.204014094416122 1.90548736252575 0.555555555555556 22.4 22 4 abnormal posterior eye segment morphology 0.0323770397710523 0.204014094416122 1.90548736252575 0.555555555555556 22.4 22 4 eye opacity 0.0323770397710523 0.204014094416122 1.90548736252575 0.555555555555556 22.4 22 4 decreased effector memory CD4-positive, alpha-beta T cell number 0.0323770397710523 0.204014094416122 1.90548736252575 0.555555555555556 22.4 22 4 abnormal infrahyoid muscle connection 0.0323770397710523 0.204014094416122 1.90548736252575 0.555555555555556 22.4 22 4 symmetric azygos veins 0.0323770397710523 0.204014094416122 1.90548736252575 0.555555555555556 22.4 22 4 decreased platelet dense granule number 0.0323770397710523 0.204014094416122 1.90548736252575 0.555555555555556 22.4 22 4 trabecula carnea hypoplasia 1.6543130396518e-06 8.23020737226772e-05 1.90548736252575 0.555555555555556 22.4 22 4 pallor 4.36388437511242e-21 1.67002498201418e-18 1.90113196283998 0.554285714285714 22.4 22 4 blood in lymph vessels 0.000140364721261434 0.00332536750633755 1.8923460703704 0.551724137931034 22.4 22 4 microcephaly 4.86077626605996e-09 4.24251963572777e-07 1.88891790719944 0.550724637681159 22.4 22 4 abnormal lens epithelium morphology 0.00164186324689604 0.0252887605365567 1.8864324889005 0.55 22.4 22 4 enlarged pericardium 6.60480334446871e-05 0.00182549425770732 1.87084213775256 0.545454545454545 22.4 22 4 abnormal ovarian folliculogenesis 6.60480334446871e-05 0.00182549425770732 1.87084213775256 0.545454545454545 22.4 22 4 abnormal sperm midpiece morphology 0.00111238056213796 0.0182042542652512 1.87084213775256 0.545454545454545 22.4 22 4 embryonic lethality before implantation, incomplete penetrance 0.00111238056213796 0.0182042542652512 1.87084213775256 0.545454545454545 22.4 22 4 absent semicircular canals 0.0211047860220713 0.152610916365995 1.87084213775256 0.545454545454545 22.4 22 4 abnormal stomach epithelium morphology 0.0211047860220713 0.152610916365995 1.87084213775256 0.545454545454545 22.4 22 4 abnormal eye distance/ position 0.0211047860220713 0.152610916365995 1.87084213775256 0.545454545454545 22.4 22 4 abnormal food preference 0.0211047860220713 0.152610916365995 1.87084213775256 0.545454545454545 22.4 22 4 abnormal hemoglobin 0.0211047860220713 0.152610916365995 1.87084213775256 0.545454545454545 22.4 22 4 vasculitis 0.0211047860220713 0.152610916365995 1.87084213775256 0.545454545454545 22.4 22 4 abnormal larynx morphology 0.0211047860220713 0.152610916365995 1.87084213775256 0.545454545454545 22.4 22 4 retinal detachment 0.0211047860220713 0.152610916365995 1.87084213775256 0.545454545454545 22.4 22 4 pulmonary hypertension 0.0211047860220713 0.152610916365995 1.87084213775256 0.545454545454545 22.4 22 4 abnormal coronal suture morphology 0.0211047860220713 0.152610916365995 1.87084213775256 0.545454545454545 22.4 22 4 pharyngeal arch hypoplasia 0.0211047860220713 0.152610916365995 1.87084213775256 0.545454545454545 22.4 22 4 abnormal spinal cord ventral horn morphology 0.0211047860220713 0.152610916365995 1.87084213775256 0.545454545454545 22.4 22 4 increased glycogen level 0.0211047860220713 0.152610916365995 1.87084213775256 0.545454545454545 22.4 22 4 abnormal extraembryonic ectoderm morphology 0.0211047860220713 0.152610916365995 1.87084213775256 0.545454545454545 22.4 22 4 decreased embryonic cilium length 0.0211047860220713 0.152610916365995 1.87084213775256 0.545454545454545 22.4 22 4 failure to gastrulate 2.84650409704784e-06 0.000126440695382259 1.86406372420998 0.543478260869565 22.4 22 4 atrial septal defect 2.84650409704784e-06 0.000126440695382259 1.86406372420998 0.543478260869565 22.4 22 4 embryonic lethality between implantation and placentation, complete penetrance 2.84650409704784e-06 0.000126440695382259 1.86406372420998 0.543478260869565 22.4 22 4 abnormal artery morphology 4.53324472456576e-05 0.0013036354048968 1.86193336566802 0.542857142857143 22.4 22 4 curly vibrissae 0.00075487305399353 0.0129947870021378 1.85785017846261 0.541666666666667 22.4 22 4 ventricular hypoplasia 0.000513019781237512 0.00970446164127994 1.84685698214035 0.538461538461538 22.4 22 4 short premaxilla 0.0138819867334299 0.113217842621006 1.84685698214035 0.538461538461538 22.4 22 4 absent common myeloid progenitor cells 0.0138819867334299 0.113217842621006 1.84685698214035 0.538461538461538 22.4 22 4 increased pituitary adenoma incidence 0.0138819867334299 0.113217842621006 1.84685698214035 0.538461538461538 22.4 22 4 abnormal coping response 0.0138819867334299 0.113217842621006 1.84685698214035 0.538461538461538 22.4 22 4 premature aging 0.000349120078463401 0.00700351770304604 1.83743424243555 0.535714285714286 22.4 22 4 prolonged QRS complex duration 0.000349120078463401 0.00700351770304604 1.83743424243555 0.535714285714286 22.4 22 4 subcutaneous edema 0.000349120078463401 0.00700351770304604 1.83743424243555 0.535714285714286 22.4 22 4 decreased erythrocyte cell number 3.37544405990545e-17 8.83833378843663e-15 1.83509356187194 0.535031847133758 22.4 22 4 delayed intramembranous bone ossification 0.00919404558457405 0.0879622630447229 1.82926786802472 0.533333333333333 22.4 22 4 abnormal olfactory nerve morphology 0.00919404558457405 0.0879622630447229 1.82926786802472 0.533333333333333 22.4 22 4 heterochrony 0.00919404558457405 0.0879622630447229 1.82926786802472 0.533333333333333 22.4 22 4 abnormal myocardial trabeculae morphology 6.94514888370737e-06 0.000280911509727188 1.82926786802472 0.533333333333333 22.4 22 4 lethality throughout fetal growth and development, complete penetrance 4.18872215779525e-20 1.48849233821653e-17 1.82325053951148 0.531578947368421 22.4 22 4 abnormal trophoblast layer morphology 2.26308992809688e-06 0.000106215777285679 1.81581736899513 0.529411764705882 22.4 22 4 abnormal direction of heart looping 0.000110783667447561 0.00270170953701773 1.81581736899513 0.529411764705882 22.4 22 4 abnormal interatrial septum morphology 0.00612224762838814 0.0662134390244153 1.81581736899513 0.529411764705882 22.4 22 4 increased hepatoma incidence 0.00612224762838814 0.0662134390244153 1.81581736899513 0.529411764705882 22.4 22 4 increased trabecular bone mass 0.00612224762838814 0.0662134390244153 1.81581736899513 0.529411764705882 22.4 22 4 extramedullary hematopoiesis 1.14798448392458e-11 1.54357373176345e-09 1.81201062398675 0.528301886792453 22.4 22 4 abnormal pharyngeal arch morphology 7.57113074379962e-05 0.00205827188253569 1.81021299439947 0.527777777777778 22.4 22 4 pale liver 1.60332741371898e-08 1.32942564720866e-06 1.80763801147713 0.527027027027027 22.4 22 4 abnormal nasal septum morphology 0.00409462929262838 0.0495975055327049 1.80519855397177 0.526315789473684 22.4 22 4 increased liver adenoma incidence 0.00409462929262838 0.0495975055327049 1.80519855397177 0.526315789473684 22.4 22 4 abnormal tumor vascularization 0.00274844386969931 0.0357010659314727 1.79660237038142 0.523809523809524 22.4 22 4 complete atrioventricular septal defect 0.00274844386969931 0.0357010659314727 1.79660237038142 0.523809523809524 22.4 22 4 double outlet right ventricle 1.87962152371789e-11 2.46082028434119e-09 1.79507594525791 0.523364485981308 22.4 22 4 muscular atrophy 1.66448991025934e-05 0.000587293425782993 1.79289038201287 0.522727272727273 22.4 22 4 abnormal embryo size 6.24624321963207e-12 9.13972353460869e-10 1.79082086637376 0.52212389380531 22.4 22 4 abnormal pulmonary artery morphology 0.00185044770348193 0.0279442079527094 1.78950117524158 0.521739130434783 22.4 22 4 small heart 7.83469341497621e-06 0.000311820797916053 1.78639440236789 0.520833333333333 22.4 22 4 abnormal keratinocyte physiology 0.00124907740620523 0.0201105504720745 1.78353617132411 0.52 22.4 22 4 kinked neural tube 3.69550962447688e-06 0.000157138122921132 1.78089780420676 0.519230769230769 22.4 22 4 decreased cell proliferation 3.05328058754248e-18 1.01267139486826e-15 1.77982819591595 0.518918918918919 22.4 22 4 abnormal cell adhesion 2.53982279384416e-06 0.000116996466660877 1.7784548716907 0.518518518518518 22.4 22 4 increased brain weight 0.000845025241316467 0.0143972622450323 1.7784548716907 0.518518518518518 22.4 22 4 decreased birth body size 1.01014857768749e-11 1.39596921499868e-09 1.77511191140557 0.517543859649123 22.4 22 4 abnormal embryonic erythropoiesis 0.000572786532608365 0.0106328843273381 1.77407444097225 0.517241379310345 22.4 22 4 decreased mean corpuscular hemoglobin 1.85887043957854e-07 1.1706177768232e-05 1.76537799763415 0.514705882352941 22.4 22 4 embryonic lethality between implantation and somite formation, complete penetrance 5.03634431731007e-23 3.1319766223272e-20 1.76393687273813 0.514285714285714 22.4 22 4 abnormal vocalization 0.000122773081587471 0.00295070570481966 1.76128831887516 0.513513513513513 22.4 22 4 abnormal double-strand DNA break repair 3.91413077427807e-05 0.00120202472852058 1.75482091990744 0.511627906976744 22.4 22 4 decreased double-positive T cell number 4.92803653648876e-10 5.32977864544165e-08 1.74923739879864 0.51 22.4 22 4 abnormal definitive hematopoiesis 3.41726965593027e-09 3.14831787745427e-07 1.73337882655569 0.505376344086022 22.4 22 4 heart inflammation 0.00198513503117295 0.0288773297663316 1.71493862627318 0.5 22.4 22 4 abnormal erythrocyte osmotic lysis 0.00198513503117295 0.0288773297663316 1.71493862627318 0.5 22.4 22 4 abnormal Mullerian duct morphology 0.00198513503117295 0.0288773297663316 1.71493862627318 0.5 22.4 22 4 decreased bone resorption 0.00198513503117295 0.0288773297663316 1.71493862627318 0.5 22.4 22 4 embryonic lethality during organogenesis, complete penetrance 1.86715528073688e-46 9.28909752166597e-43 1.71493862627318 0.5 22.4 22 4 small liver 1.0417427208865e-07 6.91022671521377e-06 1.71493862627318 0.5 22.4 22 4 embryonic lethality between somite formation and embryo turning, complete penetrance 4.62740375258609e-07 2.64613030679492e-05 1.71493862627318 0.5 22.4 22 4 absent mesoderm 3.00666132140153e-06 0.000132372921008607 1.71493862627318 0.5 22.4 22 4 increased B cell derived lymphoma incidence 1.97628535058319e-05 0.000678070318562162 1.71493862627318 0.5 22.4 22 4 abnormal myelin sheath morphology 4.21546963755211e-05 0.00126337117149529 1.71493862627318 0.5 22.4 22 4 disheveled coat 9.02036634865126e-05 0.00236191171497579 1.71493862627318 0.5 22.4 22 4 abnormal retinal blood vessel morphology 0.000284458611414097 0.00615296344254406 1.71493862627318 0.5 22.4 22 4 abnormal embryonic hematopoiesis 0.000615580585861811 0.0111364124169546 1.71493862627318 0.5 22.4 22 4 abnormal mitotic spindle morphology 0.00134093040416954 0.0214505747933873 1.71493862627318 0.5 22.4 22 4 abnormal germ layer development 0.00438450717726066 0.0519355314449328 1.71493862627318 0.5 22.4 22 4 intracerebral hemorrhage 0.00438450717726066 0.0519355314449328 1.71493862627318 0.5 22.4 22 4 testis hypoplasia 0.00438450717726066 0.0519355314449328 1.71493862627318 0.5 22.4 22 4 abnormal mesenteric lymph node morphology 0.00438450717726066 0.0519355314449328 1.71493862627318 0.5 22.4 22 4 increased mammary gland tumor incidence 0.00438450717726066 0.0519355314449328 1.71493862627318 0.5 22.4 22 4 abnormal physiological neovascularization 0.00654739533836074 0.0693048761879674 1.71493862627318 0.5 22.4 22 4 abnormal sperm mitochondrial sheath morphology 0.00654739533836074 0.0693048761879674 1.71493862627318 0.5 22.4 22 4 increased skin tumor incidence 0.00654739533836074 0.0693048761879674 1.71493862627318 0.5 22.4 22 4 abnormal megakaryocyte differentiation 0.00981681057401744 0.091458113493889 1.71493862627318 0.5 22.4 22 4 abnormal thymus medulla morphology 0.00981681057401744 0.091458113493889 1.71493862627318 0.5 22.4 22 4 absent allantois 0.00981681057401744 0.091458113493889 1.71493862627318 0.5 22.4 22 4 darkened coat color 0.00981681057401744 0.091458113493889 1.71493862627318 0.5 22.4 22 4 abnormal pregnancy 0.00981681057401744 0.091458113493889 1.71493862627318 0.5 22.4 22 4 increased gastrointestinal tumor incidence 0.00981681057401744 0.091458113493889 1.71493862627318 0.5 22.4 22 4 increased effector memory CD4-positive, alpha-beta T cell number 0.00981681057401744 0.091458113493889 1.71493862627318 0.5 22.4 22 4 vasculature congestion 0.0147915587562396 0.116806356844908 1.71493862627318 0.5 22.4 22 4 abnormal hair follicle orientation 0.0147915587562396 0.116806356844908 1.71493862627318 0.5 22.4 22 4 increased intestinal adenocarcinoma incidence 0.0147915587562396 0.116806356844908 1.71493862627318 0.5 22.4 22 4 impaired muscle relaxation 0.0147915587562396 0.116806356844908 1.71493862627318 0.5 22.4 22 4 abnormal pulmonary elastic fiber morphology 0.0147915587562396 0.116806356844908 1.71493862627318 0.5 22.4 22 4 increased cochlear outer hair cell number 0.0147915587562396 0.116806356844908 1.71493862627318 0.5 22.4 22 4 decreased liver cholesterol level 0.0147915587562396 0.116806356844908 1.71493862627318 0.5 22.4 22 4 abnormal pulmonary alveolus wall morphology 0.0147915587562396 0.116806356844908 1.71493862627318 0.5 22.4 22 4 decreased fibroblast apoptosis 0.0147915587562396 0.116806356844908 1.71493862627318 0.5 22.4 22 4 abnormal interparietal bone morphology 0.0224249835282332 0.157420007219739 1.71493862627318 0.5 22.4 22 4 abnormal vascular endothelial cell migration 0.0224249835282332 0.157420007219739 1.71493862627318 0.5 22.4 22 4 abnormal vitelline vein topology 0.0224249835282332 0.157420007219739 1.71493862627318 0.5 22.4 22 4 amyloidosis 0.0342679185175791 0.208669393665797 1.71493862627318 0.5 22.4 22 4 abnormal enteric nervous system morphology 0.0342679185175791 0.208669393665797 1.71493862627318 0.5 22.4 22 4 increased papilloma incidence 0.0342679185175791 0.208669393665797 1.71493862627318 0.5 22.4 22 4 abnormal aorta elastic fiber morphology 0.0342679185175791 0.208669393665797 1.71493862627318 0.5 22.4 22 4 increased osteosarcoma incidence 0.0342679185175791 0.208669393665797 1.71493862627318 0.5 22.4 22 4 abnormal nucleotide metabolism 0.0342679185175791 0.208669393665797 1.71493862627318 0.5 22.4 22 4 stria vascularis degeneration 0.0342679185175791 0.208669393665797 1.71493862627318 0.5 22.4 22 4 hematuria 0.0342679185175791 0.208669393665797 1.71493862627318 0.5 22.4 22 4 abnormal fatty acid level 0.0342679185175791 0.208669393665797 1.71493862627318 0.5 22.4 22 4 increased skeletal muscle glycogen level 0.0342679185175791 0.208669393665797 1.71493862627318 0.5 22.4 22 4 abnormal colon goblet cell morphology 0.0342679185175791 0.208669393665797 1.71493862627318 0.5 22.4 22 4 enlarged testis 0.0529212795412015 0.253157082420652 1.71493862627318 0.5 22.4 22 4 absent trophoblast giant cells 0.0529212795412015 0.253157082420652 1.71493862627318 0.5 22.4 22 4 abnormal mammary gland physiology 0.0529212795412015 0.253157082420652 1.71493862627318 0.5 22.4 22 4 decreased incidence of induced tumors 0.0529212795412015 0.253157082420652 1.71493862627318 0.5 22.4 22 4 abnormal respiratory mechanics 0.0529212795412015 0.253157082420652 1.71493862627318 0.5 22.4 22 4 increased heart rate variability 0.0529212795412015 0.253157082420652 1.71493862627318 0.5 22.4 22 4 absent coat pigmentation 0.0529212795412015 0.253157082420652 1.71493862627318 0.5 22.4 22 4 osteosclerosis 0.0529212795412015 0.253157082420652 1.71493862627318 0.5 22.4 22 4 increased platelet aggregation 0.0529212795412015 0.253157082420652 1.71493862627318 0.5 22.4 22 4 absent inguinal lymph nodes 0.0529212795412015 0.253157082420652 1.71493862627318 0.5 22.4 22 4 abnormal hippocampus neuron morphology 0.0529212795412015 0.253157082420652 1.71493862627318 0.5 22.4 22 4 increased circulating fructosamine level 0.0529212795412015 0.253157082420652 1.71493862627318 0.5 22.4 22 4 acanthocytosis 0.0529212795412015 0.253157082420652 1.71493862627318 0.5 22.4 22 4 abnormal left subclavian artery morphology 0.0529212795412015 0.253157082420652 1.71493862627318 0.5 22.4 22 4 thick aortic valve cusps 0.0529212795412015 0.253157082420652 1.71493862627318 0.5 22.4 22 4 decreased macrophage apoptosis 0.0529212795412015 0.253157082420652 1.71493862627318 0.5 22.4 22 4 lethality during fetal growth through weaning, complete penetrance 0.0529212795412015 0.253157082420652 1.71493862627318 0.5 22.4 22 4 prenatal lethality, complete penetrance 1.20311068541152e-22 6.34436055582439e-20 1.69026325035558 0.492805755395683 22.4 22 4 ventricular septal defect 7.85756133436528e-12 1.11689621824192e-09 1.68971894059269 0.492647058823529 22.4 22 4 abnormal rostral-caudal axis patterning 1.43326517312611e-05 0.000528184758244622 1.6837579239773 0.490909090909091 22.4 22 4 decreased circulating total protein level 1.43326517312611e-05 0.000528184758244622 1.6837579239773 0.490909090909091 22.4 22 4 increased circulating bilirubin level 2.08937441425292e-05 0.000707118211626415 1.68258129370199 0.490566037735849 22.4 22 4 increased T cell derived lymphoma incidence 4.44834079560788e-05 0.0012941810209444 1.67993987879822 0.489795918367347 22.4 22 4 abnormal craniofacial development 4.44834079560788e-05 0.0012941810209444 1.67993987879822 0.489795918367347 22.4 22 4 abnormal cell migration 9.49745739974832e-05 0.00247381416564125 1.67682887902266 0.488888888888889 22.4 22 4 increased tumor growth/size 0.000203459406960534 0.00462196598003952 1.67311085490066 0.48780487804878 22.4 22 4 abnormal cell differentiation 0.000203459406960534 0.00462196598003952 1.67311085490066 0.48780487804878 22.4 22 4 failure of heart looping 0.000298230407122828 0.00632321274631529 1.67096584098412 0.487179487179487 22.4 22 4 abnormal angiogenesis 7.50665958038888e-07 4.05930776222116e-05 1.6685889336712 0.486486486486487 22.4 22 4 hydrops fetalis 1.08962483258032e-06 5.67528836785071e-05 1.66730144221003 0.486111111111111 22.4 22 4 abnormal embryonic epiblast morphology 0.000642998019525909 0.0114656456886788 1.66594037980823 0.485714285714286 22.4 22 4 holoprosencephaly 0.000642998019525909 0.0114656456886788 1.66594037980823 0.485714285714286 22.4 22 4 abnormal embryo development 2.62668772989613e-11 3.18726133078859e-09 1.6644992549122 0.485294117647059 22.4 22 4 belly spot 0.000946038454607394 0.0158469404433393 1.66297078911339 0.484848484848485 22.4 22 4 anophthalmia 8.42311419673064e-08 5.82013793454652e-06 1.65713170628644 0.48314606741573 22.4 22 4 lordosis 0.00205786468429329 0.0296148951669335 1.6558028115741 0.482758620689655 22.4 22 4 abnormal atrioventricular cushion morphology 0.00304380840746826 0.038531671315915 1.65142238085565 0.481481481481481 22.4 22 4 abnormal fetal cardiomyocyte proliferation 0.00304380840746826 0.038531671315915 1.65142238085565 0.481481481481481 22.4 22 4 decreased circulating fructosamine level 0.00304380840746826 0.038531671315915 1.65142238085565 0.481481481481481 22.4 22 4 abnormal bone trabecula morphology 0.00304380840746826 0.038531671315915 1.65142238085565 0.481481481481481 22.4 22 4 abnormal interventricular septum morphology 6.73023812947685e-05 0.00184988589470427 1.64634108122225 0.48 22.4 22 4 ruffled hair 0.0045124330730612 0.0526585226027577 1.64634108122225 0.48 22.4 22 4 spontaneous skin ulceration 0.0045124330730612 0.0526585226027577 1.64634108122225 0.48 22.4 22 4 abnormal vertebrae development 0.0045124330730612 0.0526585226027577 1.64634108122225 0.48 22.4 22 4 decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 0.0045124330730612 0.0526585226027577 1.64634108122225 0.48 22.4 22 4 embryonic lethality, complete penetrance 1.38511188986978e-23 9.84418807443163e-21 1.64505084526518 0.479623824451411 22.4 22 4 astrocytosis 1.63985904243945e-06 8.23020737226772e-05 1.64446169642634 0.479452054794521 22.4 22 4 vertebral transformation 9.82043514308154e-05 0.00251838478540364 1.64348285017846 0.479166666666667 22.4 22 4 thymus hypoplasia 5.91073628913132e-11 7.00140786629246e-09 1.64037607730478 0.478260869565217 22.4 22 4 abnormal cell death 0.000143392795150949 0.00338094386671075 1.64037607730478 0.478260869565217 22.4 22 4 abnormal blood vessel physiology 0.00670739502822448 0.0701035509777664 1.64037607730478 0.478260869565217 22.4 22 4 dilated heart 0.00670739502822448 0.0701035509777664 1.64037607730478 0.478260869565217 22.4 22 4 abnormal palatal shelf fusion at midline 0.00670739502822448 0.0701035509777664 1.64037607730478 0.478260869565217 22.4 22 4 decreased effector memory CD8-positive, alpha-beta T cell number 0.00670739502822448 0.0701035509777664 1.64037607730478 0.478260869565217 22.4 22 4 decreased embryo size 5.11146671618892e-34 5.08590938260797e-31 1.63600839661207 0.476987447698745 22.4 22 4 edema 3.72287431163742e-13 7.12357680784467e-11 1.63517403900466 0.476744186046512 22.4 22 4 hemorrhage 2.09138600136239e-17 5.78035853154328e-15 1.63466490334124 0.476595744680851 22.4 22 4 skin edema 0.000306419173755098 0.00637839075075988 1.63327488216493 0.476190476190476 22.4 22 4 abnormal cytotoxic T cell physiology 0.000306419173755098 0.00637839075075988 1.63327488216493 0.476190476190476 22.4 22 4 vascular ring 0.0100009875825984 0.0916296744446171 1.63327488216493 0.476190476190476 22.4 22 4 absent segment of posterior cerebral artery 0.0100009875825984 0.0916296744446171 1.63327488216493 0.476190476190476 22.4 22 4 increased muscle cell glucose uptake 0.0100009875825984 0.0916296744446171 1.63327488216493 0.476190476190476 22.4 22 4 increased mean corpuscular hemoglobin 4.28383841869746e-08 3.13413178426763e-06 1.62832556434019 0.474747474747475 22.4 22 4 small superior vagus ganglion 0.0149667737272676 0.117629856703249 1.62467869857459 0.473684210526316 22.4 22 4 increased malignant tumor incidence 0.0149667737272676 0.117629856703249 1.62467869857459 0.473684210526316 22.4 22 4 abnormal blastocyst morphology 0.0149667737272676 0.117629856703249 1.62467869857459 0.473684210526316 22.4 22 4 abnormal trophoblast giant cell morphology 0.000963796437310161 0.016036412293037 1.61966425814689 0.472222222222222 22.4 22 4 abnormal lysosome morphology 0.000963796437310161 0.016036412293037 1.61966425814689 0.472222222222222 22.4 22 4 abnormal muscle physiology 2.70420621881053e-07 1.6816782423228e-05 1.61859375962862 0.471910112359551 22.4 22 4 enlarged liver sinusoidal spaces 0.00141526860697691 0.0220030041240941 1.61405988355123 0.470588235294118 22.4 22 4 abnormal spleen red pulp morphology 0.00141526860697691 0.0220030041240941 1.61405988355123 0.470588235294118 22.4 22 4 abnormal bone marrow cavity morphology 0.0224976130921074 0.157420007219739 1.61405988355123 0.470588235294118 22.4 22 4 distended urinary bladder 0.0224976130921074 0.157420007219739 1.61405988355123 0.470588235294118 22.4 22 4 increased incidence of corneal inflammation 0.0224976130921074 0.157420007219739 1.61405988355123 0.470588235294118 22.4 22 4 abnormal cranial suture morphology 0.0224976130921074 0.157420007219739 1.61405988355123 0.470588235294118 22.4 22 4 decreased vasoconstriction 0.0224976130921074 0.157420007219739 1.61405988355123 0.470588235294118 22.4 22 4 pancytopenia 0.0224976130921074 0.157420007219739 1.61405988355123 0.470588235294118 22.4 22 4 increased brain size 0.0224976130921074 0.157420007219739 1.61405988355123 0.470588235294118 22.4 22 4 decreased body fat mass 0.0224976130921074 0.157420007219739 1.61405988355123 0.470588235294118 22.4 22 4 impaired hematopoiesis 0.000100036427313195 0.00252860426788029 1.61405988355123 0.470588235294118 22.4 22 4 pancreatic islet hyperplasia 0.00208095780521617 0.02974932494526 1.6077549621311 0.46875 22.4 22 4 decreased hemoglobin content 1.90025235807535e-10 2.19854778637787e-08 1.60547445863872 0.468085106382979 22.4 22 4 abnormal cell nucleus morphology 0.000212401808832305 0.00475990540063386 1.60547445863872 0.468085106382979 22.4 22 4 increased tumor incidence 2.41142286659468e-09 2.30708245409779e-07 1.60429742457813 0.467741935483871 22.4 22 4 embryonic growth arrest 6.08884269629818e-16 1.44247582924207e-13 1.6026064018448 0.467248908296943 22.4 22 4 spleen hyperplasia 3.58168205238881e-06 0.00015446400101959 1.60060938452163 0.466666666666667 22.4 22 4 increased metastatic potential 0.00306425761068054 0.0385941306661663 1.60060938452163 0.466666666666667 22.4 22 4 abnormal brain vasculature morphology 0.00306425761068054 0.0385941306661663 1.60060938452163 0.466666666666667 22.4 22 4 macrocytosis 0.034002054228935 0.208669393665797 1.60060938452163 0.466666666666667 22.4 22 4 abnormal glial cell morphology 0.034002054228935 0.208669393665797 1.60060938452163 0.466666666666667 22.4 22 4 abnormal energy homeostasis 0.034002054228935 0.208669393665797 1.60060938452163 0.466666666666667 22.4 22 4 abnormal dendritic cell morphology 0.034002054228935 0.208669393665797 1.60060938452163 0.466666666666667 22.4 22 4 abnormal aorta wall morphology 0.034002054228935 0.208669393665797 1.60060938452163 0.466666666666667 22.4 22 4 liver vascular congestion 0.034002054228935 0.208669393665797 1.60060938452163 0.466666666666667 22.4 22 4 abnormal vasculogenesis 0.000452048887402944 0.00864978159549865 1.5952917453704 0.465116279069767 22.4 22 4 decreased circulating serum albumin level 1.33213107860657e-07 8.49660527700987e-06 1.59368033956699 0.464646464646465 22.4 22 4 small superior cervical ganglion 0.00451963601032714 0.0526585226027577 1.59244301011081 0.464285714285714 22.4 22 4 lethality throughout fetal growth and development, incomplete penetrance 1.75861008131417e-12 2.82228553372194e-10 1.59039001095725 0.463687150837989 22.4 22 4 increased cell proliferation 0.000100635908550814 0.00252860426788029 1.58790613543813 0.462962962962963 22.4 22 4 rib fusion 1.57185467201833e-05 0.000562588272898648 1.58695813177518 0.462686567164179 22.4 22 4 abnormal placenta vasculature 0.000146221906168406 0.00341527691637473 1.58302027040601 0.461538461538462 22.4 22 4 pulmonary edema 0.00667868853753682 0.0701035509777664 1.58302027040601 0.461538461538462 22.4 22 4 abnormal mast cell morphology 0.0517415743325643 0.251873123585624 1.58302027040601 0.461538461538462 22.4 22 4 abnormal renal/urinary system morphology 0.0517415743325643 0.251873123585624 1.58302027040601 0.461538461538462 22.4 22 4 increased foot pad pigmentation 0.0517415743325643 0.251873123585624 1.58302027040601 0.461538461538462 22.4 22 4 lymphoid hypoplasia 0.0517415743325643 0.251873123585624 1.58302027040601 0.461538461538462 22.4 22 4 axonal dystrophy 0.0517415743325643 0.251873123585624 1.58302027040601 0.461538461538462 22.4 22 4 muscle fatigue 0.0517415743325643 0.251873123585624 1.58302027040601 0.461538461538462 22.4 22 4 increased cochlear inner hair cell number 0.0517415743325643 0.251873123585624 1.58302027040601 0.461538461538462 22.4 22 4 increased circulating thyroxine level 0.0517415743325643 0.251873123585624 1.58302027040601 0.461538461538462 22.4 22 4 abnormal aorta tunica media morphology 0.0517415743325643 0.251873123585624 1.58302027040601 0.461538461538462 22.4 22 4 increased embryonic tissue cell apoptosis 3.60157268708994e-06 0.00015446400101959 1.58302027040601 0.461538461538462 22.4 22 4 malocclusion 0.00141103418898774 0.0220030041240941 1.57588954846724 0.459459459459459 22.4 22 4 increased circulating phosphate level 0.00141103418898774 0.0220030041240941 1.57588954846724 0.459459459459459 22.4 22 4 polydactyly 2.77800530831039e-07 1.70624400109187e-05 1.57494363637333 0.459183673469388 22.4 22 4 abnormal digestive system morphology 0.00989009498420877 0.0916261127494202 1.57202707408375 0.458333333333333 22.4 22 4 hemolytic anemia 0.00989009498420877 0.0916261127494202 1.57202707408375 0.458333333333333 22.4 22 4 abnormal tumor morphology 0.00989009498420877 0.0916261127494202 1.57202707408375 0.458333333333333 22.4 22 4 abnormal neural tube closure 2.49305607523583e-06 0.000115915457703722 1.57030524815375 0.457831325301205 22.4 22 4 increased carcinoma incidence 0.00206560173325144 0.0296148951669335 1.56794388687833 0.457142857142857 22.4 22 4 increased circulating serum albumin level 0.00206560173325144 0.0296148951669335 1.56794388687833 0.457142857142857 22.4 22 4 preweaning lethality, complete penetrance 9.22324979131389e-45 2.29428338558933e-41 1.56661960994685 0.456756756756757 22.4 22 4 increased hepatocellular carcinoma incidence 0.000100174469286836 0.00252860426788029 1.5645054134422 0.456140350877193 22.4 22 4 abnormal response to infection 5.18434244960431e-06 0.000211410685957225 1.56298203913505 0.455696202531646 22.4 22 4 decreased B cell proliferation 5.18434244960431e-06 0.000211410685957225 1.56298203913505 0.455696202531646 22.4 22 4 abnormal head morphology 0.000145156500691529 0.00340638486292621 1.5590351147938 0.454545454545455 22.4 22 4 embryonic lethality, incomplete penetrance 0.00065414802941985 0.0116228087370134 1.5590351147938 0.454545454545455 22.4 22 4 abnormal facial nerve morphology 0.0146813879203798 0.116806356844908 1.5590351147938 0.454545454545455 22.4 22 4 intestinal inflammation 0.0146813879203798 0.116806356844908 1.5590351147938 0.454545454545455 22.4 22 4 abnormal basement membrane morphology 0.0146813879203798 0.116806356844908 1.5590351147938 0.454545454545455 22.4 22 4 abnormal cerebral cortex pyramidal cell morphology 0.0146813879203798 0.116806356844908 1.5590351147938 0.454545454545455 22.4 22 4 increased bone volume 0.0146813879203798 0.116806356844908 1.5590351147938 0.454545454545455 22.4 22 4 decreased atrioventricular cushion size 0.0794350241404767 0.336296110969262 1.5590351147938 0.454545454545455 22.4 22 4 abnormal awl hair morphology 0.0794350241404767 0.336296110969262 1.5590351147938 0.454545454545455 22.4 22 4 failure of somite differentiation 0.0794350241404767 0.336296110969262 1.5590351147938 0.454545454545455 22.4 22 4 abnormal fear/anxiety-related behavior 0.0794350241404767 0.336296110969262 1.5590351147938 0.454545454545455 22.4 22 4 abnormal bronchiole morphology 0.0794350241404767 0.336296110969262 1.5590351147938 0.454545454545455 22.4 22 4 fatigue 0.0794350241404767 0.336296110969262 1.5590351147938 0.454545454545455 22.4 22 4 abnormal radial glial cell morphology 0.0794350241404767 0.336296110969262 1.5590351147938 0.454545454545455 22.4 22 4 palatal shelf hypoplasia 0.0794350241404767 0.336296110969262 1.5590351147938 0.454545454545455 22.4 22 4 abnormal palatal shelf elevation 0.0794350241404767 0.336296110969262 1.5590351147938 0.454545454545455 22.4 22 4 decreased palatine bone horizontal plate size 0.0794350241404767 0.336296110969262 1.5590351147938 0.454545454545455 22.4 22 4 aorta dilation 0.0794350241404767 0.336296110969262 1.5590351147938 0.454545454545455 22.4 22 4 common atrioventricular valve 0.0794350241404767 0.336296110969262 1.5590351147938 0.454545454545455 22.4 22 4 decreased core body temperature 0.0794350241404767 0.336296110969262 1.5590351147938 0.454545454545455 22.4 22 4 chylous ascites 0.0794350241404767 0.336296110969262 1.5590351147938 0.454545454545455 22.4 22 4 hypolactation 0.0794350241404767 0.336296110969262 1.5590351147938 0.454545454545455 22.4 22 4 abnormal axon morphology 1.33102809837981e-07 8.49660527700987e-06 1.55614801272937 0.453703703703704 22.4 22 4 atrioventricular septal defect 0.00021037250039185 0.00473576103823281 1.55315196341722 0.452830188679245 22.4 22 4 abnormal object recognition memory 0.00443971262706375 0.0523402140275881 1.54897682373061 0.451612903225806 22.4 22 4 pale kidney 0.00443971262706375 0.0523402140275881 1.54897682373061 0.451612903225806 22.4 22 4 small lung 0.000304940255114449 0.00637839075075988 1.54680738840326 0.450980392156863 22.4 22 4 abnormal skeletal muscle fiber morphology 2.24075385931985e-05 0.000743183363341083 1.54586017016174 0.450704225352113 22.4 22 4 increased grip strength 1.70192739198721e-06 8.38325621300629e-05 1.54532931158682 0.450549450549451 22.4 22 4 muscular ventricular septal defect 9.88203002631518e-05 0.00252118458363682 1.54344476364586 0.45 22.4 22 4 waved hair 0.0218553560454641 0.155997699176735 1.54344476364586 0.45 22.4 22 4 abnormal Peyer's patch T cell area morphology 0.0218553560454641 0.155997699176735 1.54344476364586 0.45 22.4 22 4 abnormal heart right ventricle morphology 0.0218553560454641 0.155997699176735 1.54344476364586 0.45 22.4 22 4 abnormal optic stalk morphology 0.0218553560454641 0.155997699176735 1.54344476364586 0.45 22.4 22 4 abnormal postnatal subventricular zone morphology 0.0218553560454641 0.155997699176735 1.54344476364586 0.45 22.4 22 4 abnormal response to tactile stimuli 0.0218553560454641 0.155997699176735 1.54344476364586 0.45 22.4 22 4 perimembraneous ventricular septal defect 3.23036062943531e-05 0.00102363338416819 1.54095934534691 0.449275362318841 22.4 22 4 decreased circulating creatinine level 0.000442092702442338 0.00855802021264837 1.53994488889836 0.448979591836735 22.4 22 4 decreased granulocyte number 0.00651982521272964 0.0693048761879674 1.53753118217595 0.448275862068966 22.4 22 4 embryonic lethality before implantation, complete penetrance 3.03387499749995e-08 2.39579811310512e-06 1.53658500914077 0.448 22.4 22 4 abnormal frontal bone morphology 0.00202134475214738 0.0292331108777128 1.534418770876 0.447368421052632 22.4 22 4 incomplete somite formation 0.00202134475214738 0.0292331108777128 1.534418770876 0.447368421052632 22.4 22 4 perinatal lethality, complete penetrance 8.12326654068817e-13 1.39356038068702e-10 1.52975746005589 0.446009389671362 22.4 22 4 small seminiferous tubules 2.20015619982113e-05 0.000734615912356384 1.52953985586527 0.445945945945946 22.4 22 4 decreased tumor growth/size 0.000298161773864678 0.00632321274631529 1.5243898900206 0.444444444444444 22.4 22 4 abnormal heart valve morphology 0.00958659264159169 0.0904996174419709 1.5243898900206 0.444444444444444 22.4 22 4 abnormal brain commissure morphology 0.00958659264159169 0.0904996174419709 1.5243898900206 0.444444444444444 22.4 22 4 abnormal palate morphology 0.00958659264159169 0.0904996174419709 1.5243898900206 0.444444444444444 22.4 22 4 oxidative stress 3.44712307105333e-06 0.000150433660337634 1.5243898900206 0.444444444444444 22.4 22 4 underdeveloped hair follicles 0.0326422551065794 0.204014094416122 1.5243898900206 0.444444444444444 22.4 22 4 eye inflammation 0.0326422551065794 0.204014094416122 1.5243898900206 0.444444444444444 22.4 22 4 abnormal thyroid cartilage morphology 0.0326422551065794 0.204014094416122 1.5243898900206 0.444444444444444 22.4 22 4 abnormal thymus cortex morphology 0.0326422551065794 0.204014094416122 1.5243898900206 0.444444444444444 22.4 22 4 increased circulating renin level 0.0326422551065794 0.204014094416122 1.5243898900206 0.444444444444444 22.4 22 4 increased circulating glycerol level 0.0326422551065794 0.204014094416122 1.5243898900206 0.444444444444444 22.4 22 4 absent inner cell mass 0.0326422551065794 0.204014094416122 1.5243898900206 0.444444444444444 22.4 22 4 decreased lactate dehydrogenase level 0.0326422551065794 0.204014094416122 1.5243898900206 0.444444444444444 22.4 22 4 abnormal aerobic respiration 0.0326422551065794 0.204014094416122 1.5243898900206 0.444444444444444 22.4 22 4 decreased fluid intake 0.0326422551065794 0.204014094416122 1.5243898900206 0.444444444444444 22.4 22 4 gliosis 9.67318019370601e-05 0.0024934752053724 1.5243898900206 0.444444444444444 22.4 22 4 embryonic lethality during organogenesis, incomplete penetrance 1.84988989856527e-13 3.6812808981449e-11 1.52107599895534 0.443478260869565 22.4 22 4 abnormal myocardium layer morphology 1.49600593205297e-05 0.000543257628610476 1.5195658713813 0.443037974683544 22.4 22 4 anemia 3.22770479676687e-12 5.0180723012235e-10 1.51174684590906 0.440758293838863 22.4 22 4 short stride length 0.000622461317827021 0.011220090783295 1.5091459911204 0.44 22.4 22 4 abnormal thyroid gland morphology 0.014115400771539 0.114371529052779 1.5091459911204 0.44 22.4 22 4 abnormal egg cylinder morphology 0.014115400771539 0.114371529052779 1.5091459911204 0.44 22.4 22 4 abnormal preimplantation embryo development 0.014115400771539 0.114371529052779 1.5091459911204 0.44 22.4 22 4 abnormal mammary gland development 0.00195605182005277 0.0288773297663316 1.5057997694106 0.439024390243902 22.4 22 4 incomplete embryo turning 0.000289287558468049 0.00620347242835579 1.50433212830981 0.43859649122807 22.4 22 4 absent vitelline blood vessels 0.000289287558468049 0.00620347242835579 1.50433212830981 0.43859649122807 22.4 22 4 preweaning lethality, incomplete penetrance 9.9585257680614e-22 4.12863880800879e-19 1.50109542348606 0.437652811735941 22.4 22 4 prenatal lethality, incomplete penetrance 1.6567936744229e-16 4.12127426512698e-14 1.50057129798903 0.4375 22.4 22 4 abnormal retinal pigment epithelium morphology 2.0850875080369e-05 0.000707118211626415 1.50057129798903 0.4375 22.4 22 4 abnormal osteoclast morphology 0.000899264504844639 0.0151143274040611 1.50057129798903 0.4375 22.4 22 4 failure of primitive streak formation 0.00627429971072298 0.0671282603459071 1.50057129798903 0.4375 22.4 22 4 abnormal lymphatic vessel morphology 0.00627429971072298 0.0671282603459071 1.50057129798903 0.4375 22.4 22 4 abnormal lumbar vertebrae morphology 0.00627429971072298 0.0671282603459071 1.50057129798903 0.4375 22.4 22 4 abnormal heart atrium morphology 0.00627429971072298 0.0671282603459071 1.50057129798903 0.4375 22.4 22 4 increased fatty acid level 0.00627429971072298 0.0671282603459071 1.50057129798903 0.4375 22.4 22 4 disorganized yolk sac vascular plexus 0.0489435507076982 0.251103196926389 1.50057129798903 0.4375 22.4 22 4 intraventricular hemorrhage 0.0489435507076982 0.251103196926389 1.50057129798903 0.4375 22.4 22 4 abnormal meiosis 0.0489435507076982 0.251103196926389 1.50057129798903 0.4375 22.4 22 4 white spotting 0.0489435507076982 0.251103196926389 1.50057129798903 0.4375 22.4 22 4 abnormal amnion morphology 0.0489435507076982 0.251103196926389 1.50057129798903 0.4375 22.4 22 4 kidney degeneration 0.0489435507076982 0.251103196926389 1.50057129798903 0.4375 22.4 22 4 decreased midbrain size 0.0489435507076982 0.251103196926389 1.50057129798903 0.4375 22.4 22 4 abnormal ovary morphology 6.341428670625e-05 0.00177239368743592 1.49755203984418 0.436619718309859 22.4 22 4 conjunctivitis 0.0208152286066532 0.152610916365995 1.49125097936798 0.434782608695652 22.4 22 4 abnormal Wolffian duct morphology 0.0208152286066532 0.152610916365995 1.49125097936798 0.434782608695652 22.4 22 4 abnormal hematopoietic stem cell physiology 0.0208152286066532 0.152610916365995 1.49125097936798 0.434782608695652 22.4 22 4 abnormal microglial cell physiology 0.00916231808488483 0.0879622630447229 1.48628014277009 0.433333333333333 22.4 22 4 liver hemorrhage 0.00916231808488483 0.0879622630447229 1.48628014277009 0.433333333333333 22.4 22 4 abnormal cellular respiration 0.00916231808488483 0.0879622630447229 1.48628014277009 0.433333333333333 22.4 22 4 thin ventricular wall 9.52552362339008e-06 0.000373145512018627 1.48628014277009 0.433333333333333 22.4 22 4 decreased bone mineral content 2.44501082418351e-11 3.04098221257825e-09 1.48408150350564 0.432692307692308 22.4 22 4 abnormal branching of the mammary ductal tree 0.00411734066030294 0.0495975055327049 1.48319016326329 0.432432432432432 22.4 22 4 increased erythroid progenitor cell number 0.00411734066030294 0.0495975055327049 1.48319016326329 0.432432432432432 22.4 22 4 increased neuron apoptosis 2.87882182887851e-05 0.000930008999913674 1.48204572640892 0.432098765432099 22.4 22 4 abnormal circadian rhythm 0.00187605335803114 0.0279442079527094 1.48108335905411 0.431818181818182 22.4 22 4 omphalocele 0.00187605335803114 0.0279442079527094 1.48108335905411 0.431818181818182 22.4 22 4 decreased blood urea nitrogen level 0.00187605335803114 0.0279442079527094 1.48108335905411 0.431818181818182 22.4 22 4 abnormal gastrulation 0.000863339365402076 0.0146092290573991 1.47955489325529 0.431372549019608 22.4 22 4 failure of chorioallantoic fusion 0.000863339365402076 0.0146092290573991 1.47955489325529 0.431372549019608 22.4 22 4 abnormal forebrain development 8.74340134994947e-05 0.00231374583595737 1.47675270595746 0.430555555555556 22.4 22 4 abnormal visceral yolk sac morphology 4.11109852638348e-05 0.00123955849507623 1.47614970362755 0.430379746835443 22.4 22 4 abnormal nervous system morphology 4.11109852638348e-05 0.00123955849507623 1.47614970362755 0.430379746835443 22.4 22 4 rib bifurcation 0.0133868101150401 0.110081620367479 1.46994739394844 0.428571428571429 22.4 22 4 hypoxia 0.0133868101150401 0.110081620367479 1.46994739394844 0.428571428571429 22.4 22 4 abnormal brainstem morphology 0.0133868101150401 0.110081620367479 1.46994739394844 0.428571428571429 22.4 22 4 abnormal hematopoietic system physiology 0.0307461323926134 0.199428955219364 1.46994739394844 0.428571428571429 22.4 22 4 liver degeneration 0.0307461323926134 0.199428955219364 1.46994739394844 0.428571428571429 22.4 22 4 left pulmonary isomerism 0.0307461323926134 0.199428955219364 1.46994739394844 0.428571428571429 22.4 22 4 absent visceral yolk sac blood islands 0.0737290174358127 0.330750100760296 1.46994739394844 0.428571428571429 22.4 22 4 abnormal fluid regulation 0.0737290174358127 0.330750100760296 1.46994739394844 0.428571428571429 22.4 22 4 absent otoliths 0.0737290174358127 0.330750100760296 1.46994739394844 0.428571428571429 22.4 22 4 skeletal muscle necrosis 0.0737290174358127 0.330750100760296 1.46994739394844 0.428571428571429 22.4 22 4 split sternum 0.0737290174358127 0.330750100760296 1.46994739394844 0.428571428571429 22.4 22 4 decreased CNS synapse formation 0.0737290174358127 0.330750100760296 1.46994739394844 0.428571428571429 22.4 22 4 spina bifida occulta 0.0737290174358127 0.330750100760296 1.46994739394844 0.428571428571429 22.4 22 4 increased pulmonary respiratory rate 0.0737290174358127 0.330750100760296 1.46994739394844 0.428571428571429 22.4 22 4 sternebra fusion 0.0737290174358127 0.330750100760296 1.46994739394844 0.428571428571429 22.4 22 4 abnormal renal tubule epithelial cell primary cilium morphology 0.0737290174358127 0.330750100760296 1.46994739394844 0.428571428571429 22.4 22 4 abnormal embryonic tissue morphology 3.43807129412048e-08 2.59157646791657e-06 1.46994739394844 0.428571428571429 22.4 22 4 abnormal midbrain development 0.00597391832874054 0.065319216891174 1.46994739394844 0.428571428571429 22.4 22 4 abnormal craniofacial morphology 4.1685452847687e-06 0.000174273216737179 1.46519028264116 0.427184466019417 22.4 22 4 neurodegeneration 0.000823648925382481 0.0140812831744943 1.46087364460308 0.425925925925926 22.4 22 4 axon degeneration 0.000823648925382481 0.0140812831744943 1.46087364460308 0.425925925925926 22.4 22 4 increased cellular sensitivity to gamma-irradiation 0.00178635916188233 0.0272611559213637 1.45952223512611 0.425531914893617 22.4 22 4 perinatal lethality, incomplete penetrance 1.93481052969053e-11 2.46812368851549e-09 1.4569390099312 0.424778761061947 22.4 22 4 decreased hematocrit 6.61357380122396e-08 4.63415910719566e-06 1.45652321683475 0.424657534246575 22.4 22 4 increased cardiomyocyte apoptosis 0.00866725028545944 0.0845481768042367 1.45509944047421 0.424242424242424 22.4 22 4 abnormal hepatocyte morphology 2.68553842252227e-06 0.00012257388671604 1.4522903681953 0.423423423423423 22.4 22 4 abnormal nasal bone morphology 0.0195689897431406 0.145742101754678 1.45110191453884 0.423076923076923 22.4 22 4 abnormal leukocyte cell number 0.0195689897431406 0.145742101754678 1.45110191453884 0.423076923076923 22.4 22 4 increased leukemia incidence 0.0195689897431406 0.145742101754678 1.45110191453884 0.423076923076923 22.4 22 4 decreased circulating glycerol level 0.0195689897431406 0.145742101754678 1.45110191453884 0.423076923076923 22.4 22 4 abnormal nerve conduction 0.0195689897431406 0.145742101754678 1.45110191453884 0.423076923076923 22.4 22 4 increased thymocyte apoptosis 0.0195689897431406 0.145742101754678 1.45110191453884 0.423076923076923 22.4 22 4 abnormal brain morphology 2.04304562680756e-08 1.66625442514223e-06 1.4486438085289 0.422360248447205 22.4 22 4 decreased caudal vertebrae number 0.000363620189319814 0.00726510217616898 1.44697946591799 0.421875 22.4 22 4 postnatal lethality 1.38078854792332e-08 1.16430898744382e-06 1.44633378119425 0.421686746987952 22.4 22 4 decreased hair follicle number 0.00564170132077968 0.0627907473621452 1.44415884317741 0.421052631578947 22.4 22 4 decreased neuron apoptosis 0.00564170132077968 0.0627907473621452 1.44415884317741 0.421052631578947 22.4 22 4 decreased total retina thickness 0.00564170132077968 0.0627907473621452 1.44415884317741 0.421052631578947 22.4 22 4 short vibrissae 0.0454971506551699 0.249282295715276 1.44415884317741 0.421052631578947 22.4 22 4 increased circulating VLDL cholesterol level 0.0454971506551699 0.249282295715276 1.44415884317741 0.421052631578947 22.4 22 4 decreased liver regeneration 0.0454971506551699 0.249282295715276 1.44415884317741 0.421052631578947 22.4 22 4 increased liver cholesterol level 0.0454971506551699 0.249282295715276 1.44415884317741 0.421052631578947 22.4 22 4 shortened RR interval 0.0454971506551699 0.249282295715276 1.44415884317741 0.421052631578947 22.4 22 4 thin interventricular septum 0.0454971506551699 0.249282295715276 1.44415884317741 0.421052631578947 22.4 22 4 embryonic lethality between implantation and somite formation, incomplete penetrance 0.0454971506551699 0.249282295715276 1.44415884317741 0.421052631578947 22.4 22 4 increased lymphocyte cell number 0.00024204166076534 0.00528139150134898 1.44154261338905 0.420289855072464 22.4 22 4 cleft palate 5.52863253125682e-07 3.09044346550592e-05 1.4400248006874 0.419847328244275 22.4 22 4 abnormal neural tube morphology 2.74770329920795e-08 2.20481030863864e-06 1.43970156279724 0.419753086419753 22.4 22 4 prenatal lethality 0.000518380913799738 0.00976873123543067 1.43833562203557 0.419354838709677 22.4 22 4 abnormal retinal photoreceptor layer morphology 0.0125730886933112 0.104775739110926 1.43833562203557 0.419354838709677 22.4 22 4 decreased double-negative T cell number 0.0125730886933112 0.104775739110926 1.43833562203557 0.419354838709677 22.4 22 4 small cranium 0.0125730886933112 0.104775739110926 1.43833562203557 0.419354838709677 22.4 22 4 abnormal mitochondrial ATP synthesis coupled electron transport 0.0125730886933112 0.104775739110926 1.43833562203557 0.419354838709677 22.4 22 4 spleen hypoplasia 7.61767057838368e-06 0.000305628315544023 1.43728189630514 0.419047619047619 22.4 22 4 abnormal left-right axis patterning 0.00368833422676532 0.045532165702624 1.43576257083336 0.418604651162791 22.4 22 4 kidney failure 0.00368833422676532 0.045532165702624 1.43576257083336 0.418604651162791 22.4 22 4 abnormal embryo turning 0.00111620278449599 0.0182069142716968 1.43431230561029 0.418181818181818 22.4 22 4 internal hemorrhage 0.000344311206417675 0.0069916255180732 1.43338153837758 0.417910447761194 22.4 22 4 abnormal somite development 0.00010757974247387 0.00264955058815594 1.43273353587379 0.417721518987342 22.4 22 4 abnormal placenta morphology 0.00010757974247387 0.00264955058815594 1.43273353587379 0.417721518987342 22.4 22 4 small spleen 3.39214197648877e-05 0.00106809533753365 1.43225643512925 0.417582417582418 22.4 22 4 abnormal behavior 7.02801905101624e-13 1.24872838495735e-10 1.43117180322078 0.41726618705036 22.4 22 4 abnormal eye morphology 3.53759916186471e-07 2.09518521789011e-05 1.43117180322078 0.41726618705036 22.4 22 4 increased erythrocyte cell number 0.000738394798094876 0.0128444549668602 1.42911552189432 0.416666666666667 22.4 22 4 impaired wound healing 0.00813597001355205 0.0795215143760735 1.42911552189432 0.416666666666667 22.4 22 4 abnormal nursing 0.0286188954798279 0.187519159207447 1.42911552189432 0.416666666666667 22.4 22 4 blindness 0.0286188954798279 0.187519159207447 1.42911552189432 0.416666666666667 22.4 22 4 increased hemangiosarcoma incidence 0.0286188954798279 0.187519159207447 1.42911552189432 0.416666666666667 22.4 22 4 decreased fatty acid level 0.0286188954798279 0.187519159207447 1.42911552189432 0.416666666666667 22.4 22 4 abnormal inner cell mass apoptosis 0.0286188954798279 0.187519159207447 1.42911552189432 0.416666666666667 22.4 22 4 abnormal lung saccule morphology 0.0286188954798279 0.187519159207447 1.42911552189432 0.416666666666667 22.4 22 4 abnormal adipose tissue distribution 0.111697242442547 0.424842340330022 1.42911552189432 0.416666666666667 22.4 22 4 abnormal embryonic growth/weight/body size 0.111697242442547 0.424842340330022 1.42911552189432 0.416666666666667 22.4 22 4 abnormal respiratory function 0.111697242442547 0.424842340330022 1.42911552189432 0.416666666666667 22.4 22 4 abnormal AMPA-mediated synaptic currents 0.111697242442547 0.424842340330022 1.42911552189432 0.416666666666667 22.4 22 4 abnormal alisphenoid bone morphology 0.111697242442547 0.424842340330022 1.42911552189432 0.416666666666667 22.4 22 4 delayed somite formation 0.111697242442547 0.424842340330022 1.42911552189432 0.416666666666667 22.4 22 4 decreased left ventricle systolic pressure 0.111697242442547 0.424842340330022 1.42911552189432 0.416666666666667 22.4 22 4 abnormal rostral-caudal body axis extension 0.111697242442547 0.424842340330022 1.42911552189432 0.416666666666667 22.4 22 4 abnormal amacrine cell morphology 0.111697242442547 0.424842340330022 1.42911552189432 0.416666666666667 22.4 22 4 abnormal somatic nervous system physiology 0.111697242442547 0.424842340330022 1.42911552189432 0.416666666666667 22.4 22 4 hemoperitoneum 0.111697242442547 0.424842340330022 1.42911552189432 0.416666666666667 22.4 22 4 abnormal thymus corticomedullary boundary morphology 0.111697242442547 0.424842340330022 1.42911552189432 0.416666666666667 22.4 22 4 decreased keratinocyte proliferation 0.111697242442547 0.424842340330022 1.42911552189432 0.416666666666667 22.4 22 4 abnormal aorta elastic tissue morphology 0.111697242442547 0.424842340330022 1.42911552189432 0.416666666666667 22.4 22 4 increased fibrosarcoma incidence 0.111697242442547 0.424842340330022 1.42911552189432 0.416666666666667 22.4 22 4 Leydig cell hyperplasia 0.00529415591522693 0.0603669885106066 1.42214422666556 0.414634146341463 22.4 22 4 hemopericardium 0.00529415591522693 0.0603669885106066 1.42214422666556 0.414634146341463 22.4 22 4 domed cranium 0.000324847274237698 0.0067338132888856 1.42094914748349 0.414285714285714 22.4 22 4 abnormal enzyme/coenzyme activity 1.02325344968733e-07 6.87930528674929e-06 1.42001287525805 0.414012738853503 22.4 22 4 increased leukocyte cell number 3.17387250295399e-07 1.90241153038507e-05 1.4192595527778 0.413793103448276 22.4 22 4 thrombocytopenia 3.17387250295399e-07 1.90241153038507e-05 1.4192595527778 0.413793103448276 22.4 22 4 abnormal spinal nerve morphology 0.0182340935754946 0.138284474905618 1.4192595527778 0.413793103448276 22.4 22 4 abnormal allantois morphology 0.00346041729561744 0.0431468071320721 1.41668843039958 0.41304347826087 22.4 22 4 decreased B cell number 1.48985353433263e-09 1.54417111110518e-07 1.41524061391476 0.412621359223301 22.4 22 4 abnormal lung development 9.5779160477292e-05 0.002481777725909 1.41230239810732 0.411764705882353 22.4 22 4 abnormal dendritic spine morphology 0.00227015610865015 0.0314596842354721 1.41230239810732 0.411764705882353 22.4 22 4 abnormal vagus nerve morphology 0.0674557070386116 0.310159096596204 1.41230239810732 0.411764705882353 22.4 22 4 abnormal glutamate-mediated receptor currents 0.0674557070386116 0.310159096596204 1.41230239810732 0.411764705882353 22.4 22 4 increased circulating magnesium level 0.0674557070386116 0.310159096596204 1.41230239810732 0.411764705882353 22.4 22 4 abnormal survival 0.0674557070386116 0.310159096596204 1.41230239810732 0.411764705882353 22.4 22 4 delayed heart development 0.0674557070386116 0.310159096596204 1.41230239810732 0.411764705882353 22.4 22 4 abnormal ductus venosus valve morphology 0.0674557070386116 0.310159096596204 1.41230239810732 0.411764705882353 22.4 22 4 decreased bone marrow cell number 0.0003055100056844 0.00637839075075988 1.40953859693686 0.410958904109589 22.4 22 4 abnormal heart ventricle morphology 0.000203043888887629 0.00462196598003952 1.40712912924979 0.41025641025641 22.4 22 4 abnormal lens fiber morphology 0.00759223393088027 0.0775592685957481 1.40712912924979 0.41025641025641 22.4 22 4 increased hepatocyte apoptosis 0.00759223393088027 0.0775592685957481 1.40712912924979 0.41025641025641 22.4 22 4 abnormal liver physiology 2.85013680208241e-05 0.000926760169304575 1.40624967354401 0.41 22.4 22 4 abnormal bone structure 8.50359237179222e-09 7.29402966373556e-07 1.40393939352934 0.409326424870466 22.4 22 4 lethality, incomplete penetrance 0.00494299021281208 0.0571892472296281 1.40313160331442 0.409090909090909 22.4 22 4 aphakia 0.0418678785656982 0.233250499288184 1.40313160331442 0.409090909090909 22.4 22 4 cleft upper lip 0.0418678785656982 0.233250499288184 1.40313160331442 0.409090909090909 22.4 22 4 abnormal occipital bone morphology 0.0418678785656982 0.233250499288184 1.40313160331442 0.409090909090909 22.4 22 4 increased circulating creatine kinase level 0.0418678785656982 0.233250499288184 1.40313160331442 0.409090909090909 22.4 22 4 abnormal maxilla morphology 0.00212129156657876 0.0299813225674128 1.39735739918555 0.407407407407407 22.4 22 4 abnormal osteoblast physiology 0.00212129156657876 0.0299813225674128 1.39735739918555 0.407407407407407 22.4 22 4 abnormal eye muscle morphology 0.0264318877504554 0.175331522078021 1.39735739918555 0.407407407407407 22.4 22 4 increased spleen weight 1.19784897272692e-05 0.000458407587639725 1.39623321785073 0.407079646017699 22.4 22 4 decreased grip strength 1.54907818931781e-09 1.57278856976655e-07 1.39387705697089 0.406392694063927 22.4 22 4 abnormal spongiotrophoblast layer morphology 0.01688278641824 0.131442664210867 1.39338763384696 0.40625 22.4 22 4 increased granulocyte number 0.000403844194786498 0.00790994042938122 1.39049077805933 0.405405405405405 22.4 22 4 kidney cysts 0.000403844194786498 0.00790994042938122 1.39049077805933 0.405405405405405 22.4 22 4 abnormal breathing pattern 0.0108759445725855 0.0971780042262445 1.39049077805933 0.405405405405405 22.4 22 4 abnormal chromosome morphology 0.0108759445725855 0.0971780042262445 1.39049077805933 0.405405405405405 22.4 22 4 arrest of spermatogenesis 0.00017816313059806 0.00412261197546674 1.38828364984019 0.404761904761905 22.4 22 4 spina bifida 0.0070521761263234 0.0732454618548203 1.38828364984019 0.404761904761905 22.4 22 4 cleft secondary palate 7.90063641555847e-05 0.00212463060364343 1.3865461233698 0.404255319148936 22.4 22 4 decreased cardiac muscle contractility 3.51791457189932e-05 0.00110073113177353 1.38514273660526 0.403846153846154 22.4 22 4 abnormal leukocyte migration 0.00300829670173167 0.0384737174578793 1.38514273660526 0.403846153846154 22.4 22 4 increased bone mineral content 2.35046411928751e-05 0.000774407880361281 1.38453760653247 0.403669724770642 22.4 22 4 abnormal facial morphology 0.00197569581743085 0.0288773297663316 1.38398555804502 0.403508771929825 22.4 22 4 pericardial effusion 0.00130128914709341 0.0208835919573862 1.38301502118805 0.403225806451613 22.4 22 4 decreased total body fat amount 4.14997885181151e-13 7.6467202917638e-11 1.37605853844674 0.401197604790419 22.4 22 4 postnatal growth retardation 1.27524835292952e-22 6.34436055582439e-20 1.37307177593768 0.400326797385621 22.4 22 4 abnormal platelet physiology 0.00279135075463395 0.0360700519592309 1.37195090101854 0.4 22.4 22 4 abnormal T-helper 2 physiology 0.00279135075463395 0.0360700519592309 1.37195090101854 0.4 22.4 22 4 abnormal blood vessel morphology 1.85137297375554e-06 9.0299809259155e-05 1.37195090101854 0.4 22.4 22 4 increased inflammatory response 0.000103240990111122 0.00258102475277806 1.37195090101854 0.4 22.4 22 4 epidermal hyperplasia 0.00183498486678531 0.0278324686349296 1.37195090101854 0.4 22.4 22 4 abnormal eating behavior 0.00183498486678531 0.0278324686349296 1.37195090101854 0.4 22.4 22 4 thick pulmonary interalveolar septum 0.0155591838371885 0.121517958540052 1.37195090101854 0.4 22.4 22 4 ovary cysts 0.0155591838371885 0.121517958540052 1.37195090101854 0.4 22.4 22 4 abnormal response to new environment 0.0242819439025677 0.167316718719217 1.37195090101854 0.4 22.4 22 4 abnormal lactation 0.0242819439025677 0.167316718719217 1.37195090101854 0.4 22.4 22 4 abnormal optic cup morphology 0.0242819439025677 0.167316718719217 1.37195090101854 0.4 22.4 22 4 abnormal inner ear vestibule morphology 0.0382878919520205 0.217694014241488 1.37195090101854 0.4 22.4 22 4 mandible hypoplasia 0.0382878919520205 0.217694014241488 1.37195090101854 0.4 22.4 22 4 abnormal cochlear outer hair cell morphology 0.0382878919520205 0.217694014241488 1.37195090101854 0.4 22.4 22 4 abnormal pericardium morphology 0.0612583470616406 0.285623501997809 1.37195090101854 0.4 22.4 22 4 abnormal circulating enzyme level 0.0612583470616406 0.285623501997809 1.37195090101854 0.4 22.4 22 4 increased urine glucose level 0.0612583470616406 0.285623501997809 1.37195090101854 0.4 22.4 22 4 abnormal hearing physiology 0.0612583470616406 0.285623501997809 1.37195090101854 0.4 22.4 22 4 abnormal hyoid bone morphology 0.0612583470616406 0.285623501997809 1.37195090101854 0.4 22.4 22 4 dilated vasculature 0.0612583470616406 0.285623501997809 1.37195090101854 0.4 22.4 22 4 kidney atrophy 0.0612583470616406 0.285623501997809 1.37195090101854 0.4 22.4 22 4 abnormal induced retinal neovascularization 0.0612583470616406 0.285623501997809 1.37195090101854 0.4 22.4 22 4 abnormal fontanelle morphology 0.100213659573731 0.393809602195349 1.37195090101854 0.4 22.4 22 4 abnormal enteric neuron morphology 0.100213659573731 0.393809602195349 1.37195090101854 0.4 22.4 22 4 hyperpigmentation 0.100213659573731 0.393809602195349 1.37195090101854 0.4 22.4 22 4 abnormal cricoid cartilage morphology 0.100213659573731 0.393809602195349 1.37195090101854 0.4 22.4 22 4 abnormal lymph node B cell domain morphology 0.100213659573731 0.393809602195349 1.37195090101854 0.4 22.4 22 4 abnormal pericyte morphology 0.100213659573731 0.393809602195349 1.37195090101854 0.4 22.4 22 4 abnormal rostral migratory stream morphology 0.100213659573731 0.393809602195349 1.37195090101854 0.4 22.4 22 4 decreased thymocyte apoptosis 0.100213659573731 0.393809602195349 1.37195090101854 0.4 22.4 22 4 absent chorion 0.100213659573731 0.393809602195349 1.37195090101854 0.4 22.4 22 4 ostium primum atrial septal defect 0.100213659573731 0.393809602195349 1.37195090101854 0.4 22.4 22 4 abnormal coronary vessel morphology 0.100213659573731 0.393809602195349 1.37195090101854 0.4 22.4 22 4 herniated liver 0.100213659573731 0.393809602195349 1.37195090101854 0.4 22.4 22 4 abnormal branching involved in lung morphogenesis 0.100213659573731 0.393809602195349 1.37195090101854 0.4 22.4 22 4 decreased circulating cholesterol level 1.06523860654431e-07 6.97310798362889e-06 1.36820240128898 0.398907103825137 22.4 22 4 abnormal heart development 7.78104734600216e-07 4.16244199423234e-05 1.36760928424317 0.39873417721519 22.4 22 4 decreased circulating HDL cholesterol level 8.55714308710852e-06 0.000337871324272737 1.36659171781144 0.3984375 22.4 22 4 short snout 4.27774468285928e-05 0.00127435807169011 1.36559927647679 0.398148148148148 22.4 22 4 increased rib number 0.000491477599988574 0.00933244679367617 1.36315634396073 0.397435897435897 22.4 22 4 abnormal bone mineralization 1.77842842901711e-05 0.000618718981423784 1.36061246382004 0.396694214876033 22.4 22 4 dermatitis 0.00258347486805121 0.0339765449559825 1.36012373807873 0.396551724137931 22.4 22 4 abnormal embryonic neuroepithelium morphology 0.00258347486805121 0.0339765449559825 1.36012373807873 0.396551724137931 22.4 22 4 abnormal T cell differentiation 8.93117099964227e-05 0.00235092993244552 1.35836722873123 0.396039603960396 22.4 22 4 abnormal lymph node morphology 0.00602229411266078 0.0657037570405425 1.3576597457996 0.395833333333333 22.4 22 4 abnormal blood circulation 0.00925161121449597 0.0881738808278112 1.35599798356484 0.395348837209302 22.4 22 4 decreased oxygen consumption 0.00925161121449597 0.0881738808278112 1.35599798356484 0.395348837209302 22.4 22 4 decreased brown adipose tissue amount 0.0222228849045474 0.157420007219739 1.35116376615463 0.393939393939394 22.4 22 4 increased osteoblast cell number 0.0222228849045474 0.157420007219739 1.35116376615463 0.393939393939394 22.4 22 4 myeloid hyperplasia 0.0222228849045474 0.157420007219739 1.35116376615463 0.393939393939394 22.4 22 4 increased osteoclast cell number 0.00238593699009731 0.0326691376267568 1.34945990264119 0.39344262295082 22.4 22 4 increased double-negative T cell number 0.00238593699009731 0.0326691376267568 1.34945990264119 0.39344262295082 22.4 22 4 enhanced long term potentiation 0.00363089294175788 0.045046614427046 1.34745177778607 0.392857142857143 22.4 22 4 corneal vascularization 0.034872820338077 0.211575952660894 1.34745177778607 0.392857142857143 22.4 22 4 increased T cell proliferation 7.68484515861551e-05 0.00207783177522349 1.34630695894343 0.392523364485981 22.4 22 4 abnormal placenta labyrinth morphology 0.000635780562679892 0.0114188025246659 1.34590120036629 0.392405063291139 22.4 22 4 kinked tail 0.000115168197820776 0.00278136788426388 1.34504990295936 0.392156862745098 22.4 22 4 abnormal extraembryonic tissue morphology 0.000115168197820776 0.00278136788426388 1.34504990295936 0.392156862745098 22.4 22 4 increased lung adenocarcinoma incidence 0.0055436617789108 0.062116480518201 1.34504990295936 0.392156862745098 22.4 22 4 abnormal gluconeogenesis 0.0055436617789108 0.062116480518201 1.34504990295936 0.392156862745098 22.4 22 4 abnormal response to novel object 0.0055436617789108 0.062116480518201 1.34504990295936 0.392156862745098 22.4 22 4 decreased T cell proliferation 3.98063874499519e-06 0.000167827777596196 1.34414108545736 0.391891891891892 22.4 22 4 abnormal cranial nerve morphology 0.0554017249679413 0.261999602391167 1.34212588143118 0.391304347826087 22.4 22 4 abnormal postnatal growth 0.0554017249679413 0.261999602391167 1.34212588143118 0.391304347826087 22.4 22 4 abnormal sacral vertebrae morphology 0.0554017249679413 0.261999602391167 1.34212588143118 0.391304347826087 22.4 22 4 abnormal B cell morphology 0.0554017249679413 0.261999602391167 1.34212588143118 0.391304347826087 22.4 22 4 abnormal corneal stroma morphology 0.0554017249679413 0.261999602391167 1.34212588143118 0.391304347826087 22.4 22 4 abnormal lens development 0.0554017249679413 0.261999602391167 1.34212588143118 0.391304347826087 22.4 22 4 abnormal chondrocyte physiology 0.0554017249679413 0.261999602391167 1.34212588143118 0.391304347826087 22.4 22 4 abnormal vertebral artery topology 0.0554017249679413 0.261999602391167 1.34212588143118 0.391304347826087 22.4 22 4 abnormal liver morphology 4.68311649376968e-07 2.64755733596638e-05 1.34129278032539 0.391061452513966 22.4 22 4 abnormal spleen morphology 6.9659916099962e-07 3.80833057799243e-05 1.3404117998457 0.390804597701149 22.4 22 4 decreased lymphocyte cell number 1.97136643679205e-05 0.000678070318562162 1.33979580177592 0.390625 22.4 22 4 abnormal osteoclast physiology 0.00219945925226399 0.0307368252247566 1.33979580177592 0.390625 22.4 22 4 increased sacral vertebrae number 0.00219945925226399 0.0307368252247566 1.33979580177592 0.390625 22.4 22 4 sparse hair 0.000587258235702547 0.010662809206643 1.33848868392053 0.390243902439024 22.4 22 4 thick ventricular wall 0.0130888430144917 0.108167764114778 1.33848868392053 0.390243902439024 22.4 22 4 increased bone trabecula number 0.0130888430144917 0.108167764114778 1.33848868392053 0.390243902439024 22.4 22 4 enlarged spleen 3.09443009584585e-10 3.49881584700753e-08 1.33384115376803 0.388888888888889 22.4 22 4 abnormal small intestine morphology 0.00509299573044271 0.058788059765551 1.33384115376803 0.388888888888889 22.4 22 4 reduced long term depression 0.0202830471795026 0.150609193608994 1.33384115376803 0.388888888888889 22.4 22 4 right pulmonary isomerism 0.08960972190445 0.359233172018242 1.33384115376803 0.388888888888889 22.4 22 4 abnormal mammary gland morphology 0.08960972190445 0.359233172018242 1.33384115376803 0.388888888888889 22.4 22 4 abnormal Peyer's patch follicle morphology 0.08960972190445 0.359233172018242 1.33384115376803 0.388888888888889 22.4 22 4 abnormal redox activity 0.08960972190445 0.359233172018242 1.33384115376803 0.388888888888889 22.4 22 4 abnormal body wall morphology 0.08960972190445 0.359233172018242 1.33384115376803 0.388888888888889 22.4 22 4 abnormal anterior eye segment morphology 0.08960972190445 0.359233172018242 1.33384115376803 0.388888888888889 22.4 22 4 abnormal eye anterior chamber morphology 0.08960972190445 0.359233172018242 1.33384115376803 0.388888888888889 22.4 22 4 abnormal glycogen homeostasis 0.08960972190445 0.359233172018242 1.33384115376803 0.388888888888889 22.4 22 4 small thoracic cage 0.08960972190445 0.359233172018242 1.33384115376803 0.388888888888889 22.4 22 4 atrioventricular block 0.08960972190445 0.359233172018242 1.33384115376803 0.388888888888889 22.4 22 4 abnormal hypoglossal nerve topology 0.08960972190445 0.359233172018242 1.33384115376803 0.388888888888889 22.4 22 4 cataract 4.06984054197481e-05 0.00123955849507623 1.33226637082379 0.388429752066116 22.4 22 4 cardiac hypertrophy 0.00022131825090037 0.00493748115797911 1.32995240404859 0.387755102040816 22.4 22 4 increased circulating LDL cholesterol level 0.00778928285399313 0.0789239963311932 1.32995240404859 0.387755102040816 22.4 22 4 increased sarcoma incidence 0.00778928285399313 0.0789239963311932 1.32995240404859 0.387755102040816 22.4 22 4 increased lung adenoma incidence 0.0316770103505191 0.204014094416122 1.32769442034052 0.387096774193548 22.4 22 4 abnormal postnatal growth/weight/body size 0.0316770103505191 0.204014094416122 1.32769442034052 0.387096774193548 22.4 22 4 decreased thymus weight 0.0316770103505191 0.204014094416122 1.32769442034052 0.387096774193548 22.4 22 4 inner cell mass degeneration 0.0316770103505191 0.204014094416122 1.32769442034052 0.387096774193548 22.4 22 4 decreased leukocyte cell number 1.5597993714427e-05 0.000562318976299089 1.32688682032815 0.386861313868613 22.4 22 4 delayed bone ossification 0.00123107532546935 0.019885064104578 1.32621920431792 0.386666666666667 22.4 22 4 osteoporosis 0.0119644466600007 0.100886647683904 1.32517984757473 0.386363636363636 22.4 22 4 abnormal heart morphology 3.23863257686734e-08 2.51753079217422e-06 1.32146785920617 0.385281385281385 22.4 22 4 distended pericardium 0.00712826495214775 0.0734226048383749 1.31918355867168 0.384615384615385 22.4 22 4 eyelids open at birth 0.00712826495214775 0.0734226048383749 1.31918355867168 0.384615384615385 22.4 22 4 abnormal female meiosis 0.00712826495214775 0.0734226048383749 1.31918355867168 0.384615384615385 22.4 22 4 thick skin 0.0499872058325704 0.251103196926389 1.31918355867168 0.384615384615385 22.4 22 4 absent teeth 0.149169535011285 0.487914817015875 1.31918355867168 0.384615384615385 22.4 22 4 abnormal grip strength 0.149169535011285 0.487914817015875 1.31918355867168 0.384615384615385 22.4 22 4 tracheoesophageal fistula 0.149169535011285 0.487914817015875 1.31918355867168 0.384615384615385 22.4 22 4 small otic vesicle 0.149169535011285 0.487914817015875 1.31918355867168 0.384615384615385 22.4 22 4 small interparietal bone 0.149169535011285 0.487914817015875 1.31918355867168 0.384615384615385 22.4 22 4 increased circulating ammonia level 0.149169535011285 0.487914817015875 1.31918355867168 0.384615384615385 22.4 22 4 empty decidua capsularis 0.149169535011285 0.487914817015875 1.31918355867168 0.384615384615385 22.4 22 4 absent hypoglossal nerve 0.149169535011285 0.487914817015875 1.31918355867168 0.384615384615385 22.4 22 4 absent gastric milk in neonates 0.00113176051494012 0.0184003547772128 1.31918355867168 0.384615384615385 22.4 22 4 abnormal iris morphology 0.0184754236915977 0.139901419886908 1.31918355867168 0.384615384615385 22.4 22 4 decreased body weight 1.01747753513981e-37 1.26548768433014e-34 1.3187573281196 0.384491114701131 22.4 22 4 increased circulating creatinine level 0.000690621561422344 0.0121639902751102 1.31611568993058 0.383720930232558 22.4 22 4 abnormal seminiferous tubule morphology 1.22604764419085e-05 0.000462089926503749 1.31556935714107 0.383561643835616 22.4 22 4 decreased circulating glucose level 1.9006942615668e-09 1.85410861790095e-07 1.31540095348552 0.383512544802867 22.4 22 4 decreased bone mineral density 4.51577901922598e-09 4.01178582511594e-07 1.31521608932229 0.383458646616541 22.4 22 4 liver inflammation 7.13240737310026e-05 0.00194965531215241 1.31478628014277 0.383333333333333 22.4 22 4 intracranial hemorrhage 0.00427865778149883 0.0512923432842329 1.31478628014277 0.383333333333333 22.4 22 4 premature death 4.13692313984958e-26 3.43019877012528e-23 1.31458710027909 0.383275261324042 22.4 22 4 hepatic necrosis 0.0109190963542655 0.0971780042262445 1.3135700116135 0.382978723404255 22.4 22 4 neuron degeneration 0.0109190963542655 0.0971780042262445 1.3135700116135 0.382978723404255 22.4 22 4 abnormal T-helper 1 physiology 0.0109190963542655 0.0971780042262445 1.3135700116135 0.382978723404255 22.4 22 4 abnormal oocyte morphology 0.0287215275007186 0.187519159207447 1.31142365538537 0.382352941176471 22.4 22 4 abnormal endoderm development 0.0287215275007186 0.187519159207447 1.31142365538537 0.382352941176471 22.4 22 4 abnormal brown adipose tissue morphology 0.0287215275007186 0.187519159207447 1.31142365538537 0.382352941176471 22.4 22 4 abnormal nervous system development 0.0287215275007186 0.187519159207447 1.31142365538537 0.382352941176471 22.4 22 4 postnatal lethality, incomplete penetrance 2.00812938759198e-17 5.78035853154328e-15 1.31035803486366 0.382042253521127 22.4 22 4 abnormal myocardial fiber morphology 0.000388286190273297 0.00769611074346476 1.30830369427026 0.381443298969072 22.4 22 4 increased incidence of induced tumors 0.0800350945502726 0.336296110969262 1.30661990573195 0.380952380952381 22.4 22 4 abnormal erythrocyte physiology 0.0800350945502726 0.336296110969262 1.30661990573195 0.380952380952381 22.4 22 4 abnormal CD4-positive, alpha-beta T cell physiology 0.00236519854327304 0.0325951876808403 1.30431951857397 0.380281690140845 22.4 22 4 increased circulating chloride level 0.00995243211171218 0.0916296744446171 1.30335335596762 0.38 22.4 22 4 abnormal axon extension 0.00995243211171218 0.0916296744446171 1.30335335596762 0.38 22.4 22 4 reduced female fertility 8.87100486936323e-08 6.04565057877837e-06 1.30098792337965 0.379310344827586 22.4 22 4 decreased trophoblast giant cell number 0.0450409311374332 0.248699924981942 1.30098792337965 0.379310344827586 22.4 22 4 decreased bone strength 0.0450409311374332 0.248699924981942 1.30098792337965 0.379310344827586 22.4 22 4 polychromatophilia 0.0450409311374332 0.248699924981942 1.30098792337965 0.379310344827586 22.4 22 4 limb grasping 2.10122537867711e-06 9.95580596087487e-05 1.30033807926208 0.379120879120879 22.4 22 4 abnormal intestine morphology 0.00216381583318267 0.030409558672553 1.29779139285538 0.378378378378378 22.4 22 4 abnormal T cell activation 0.00216381583318267 0.030409558672553 1.29779139285538 0.378378378378378 22.4 22 4 impaired skeletal muscle contractility 0.0260091096358871 0.173990348846659 1.29779139285538 0.378378378378378 22.4 22 4 abnormal calcium ion homeostasis 0.0260091096358871 0.173990348846659 1.29779139285538 0.378378378378378 22.4 22 4 skin inflammation 0.0260091096358871 0.173990348846659 1.29779139285538 0.378378378378378 22.4 22 4 abnormal ectoderm development 0.0152660277942584 0.119792568259362 1.29573140651751 0.377777777777778 22.4 22 4 abnormal mesoderm development 0.00906216310493358 0.087712570908647 1.29429330284768 0.377358490566038 22.4 22 4 abnormal placenta development 0.00906216310493358 0.087712570908647 1.29429330284768 0.377358490566038 22.4 22 4 abnormal vertebrae morphology 0.000274900146472753 0.00597217567118754 1.29013731517799 0.376146788990826 22.4 22 4 cyanosis 2.04104575060034e-06 9.85844913518125e-05 1.28620396970488 0.375 22.4 22 4 curly tail 0.0138571776992283 0.113217842621006 1.28620396970488 0.375 22.4 22 4 scoliosis 0.0405535447098865 0.228228376619553 1.28620396970488 0.375 22.4 22 4 kidney cortex cysts 0.0405535447098865 0.228228376619553 1.28620396970488 0.375 22.4 22 4 neonatal lethality 0.0405535447098865 0.228228376619553 1.28620396970488 0.375 22.4 22 4 bradykinesia 0.0405535447098865 0.228228376619553 1.28620396970488 0.375 22.4 22 4 decreased body height 0.0714714226608093 0.325018581112913 1.28620396970488 0.375 22.4 22 4 ocular hypertelorism 0.0714714226608093 0.325018581112913 1.28620396970488 0.375 22.4 22 4 abnormal startle reflex 0.0714714226608093 0.325018581112913 1.28620396970488 0.375 22.4 22 4 small lymph nodes 0.0714714226608093 0.325018581112913 1.28620396970488 0.375 22.4 22 4 abnormal cardiac muscle contractility 0.0714714226608093 0.325018581112913 1.28620396970488 0.375 22.4 22 4 increased body temperature 0.0714714226608093 0.325018581112913 1.28620396970488 0.375 22.4 22 4 increased circulating total protein level 0.0714714226608093 0.325018581112913 1.28620396970488 0.375 22.4 22 4 abnormal tympanic ring morphology 0.13097572489335 0.441914998237266 1.28620396970488 0.375 22.4 22 4 abnormal mouth morphology 0.13097572489335 0.441914998237266 1.28620396970488 0.375 22.4 22 4 disorganized retinal layers 0.13097572489335 0.441914998237266 1.28620396970488 0.375 22.4 22 4 poor circulation 0.13097572489335 0.441914998237266 1.28620396970488 0.375 22.4 22 4 large intestinal inflammation 0.13097572489335 0.441914998237266 1.28620396970488 0.375 22.4 22 4 small pancreas 0.13097572489335 0.441914998237266 1.28620396970488 0.375 22.4 22 4 blepharitis 0.13097572489335 0.441914998237266 1.28620396970488 0.375 22.4 22 4 loose skin 0.13097572489335 0.441914998237266 1.28620396970488 0.375 22.4 22 4 increased heart left ventricle size 0.13097572489335 0.441914998237266 1.28620396970488 0.375 22.4 22 4 embryonic lethality between somite formation and embryo turning, incomplete penetrance 0.13097572489335 0.441914998237266 1.28620396970488 0.375 22.4 22 4 decreased body size 5.27845949947308e-22 2.38730327362532e-19 1.28512944675609 0.37468671679198 22.4 22 4 infertility 0.000375694104533442 0.00747631268021549 1.28219710375565 0.373831775700935 22.4 22 4 neonatal lethality, incomplete penetrance 5.18413882255449e-08 3.73783922350849e-06 1.27960805191153 0.373076923076923 22.4 22 4 distended abdomen 0.0125701394968131 0.104775739110926 1.27779740781139 0.372549019607843 22.4 22 4 abnormal cervical vertebrae morphology 0.0125701394968131 0.104775739110926 1.27779740781139 0.372549019607843 22.4 22 4 increased blood urea nitrogen level 4.51573808885897e-05 0.0013036354048968 1.27733359750002 0.372413793103448 22.4 22 4 abnormal hippocampus pyramidal cell morphology 0.036499276029168 0.217694014241488 1.27395440808865 0.371428571428571 22.4 22 4 decreased platelet aggregation 0.0113969674428694 0.0991540479884161 1.2703249083505 0.37037037037037 22.4 22 4 abnormal trigeminal nerve morphology 0.063843275292638 0.296011458136882 1.2703249083505 0.37037037037037 22.4 22 4 abnormal skin appearance 0.063843275292638 0.296011458136882 1.2703249083505 0.37037037037037 22.4 22 4 decreased bone ossification 0.063843275292638 0.296011458136882 1.2703249083505 0.37037037037037 22.4 22 4 increased exploration in new environment 0.00225865722959159 0.0313877645732351 1.2703249083505 0.37037037037037 22.4 22 4 respiratory distress 1.21318852984804e-05 0.00046073381190794 1.26885632464143 0.369942196531792 22.4 22 4 small testis 4.16099513375335e-08 3.08969414782431e-06 1.26756333246278 0.369565217391304 22.4 22 4 abnormal inner ear morphology 0.0192337077638759 0.144762021369565 1.26756333246278 0.369565217391304 22.4 22 4 abnormal sleep pattern 0.0192337077638759 0.144762021369565 1.26756333246278 0.369565217391304 22.4 22 4 decreased body length 5.60742668029705e-08 3.98527824778255e-06 1.26429781936928 0.368613138686131 22.4 22 4 persistence of hyaloid vascular system 0.0328455010625246 0.204577720665555 1.26363898778024 0.368421052631579 22.4 22 4 impaired branching involved in ureteric bud morphogenesis 0.0328455010625246 0.204577720665555 1.26363898778024 0.368421052631579 22.4 22 4 irregular coat pigmentation 0.115342055133197 0.435376877304746 1.26363898778024 0.368421052631579 22.4 22 4 unresponsive to tactile stimuli 0.115342055133197 0.435376877304746 1.26363898778024 0.368421052631579 22.4 22 4 decreased tumor incidence 0.115342055133197 0.435376877304746 1.26363898778024 0.368421052631579 22.4 22 4 decreased germ cell number 0.115342055133197 0.435376877304746 1.26363898778024 0.368421052631579 22.4 22 4 oliguria 0.115342055133197 0.435376877304746 1.26363898778024 0.368421052631579 22.4 22 4 absent amnion 0.115342055133197 0.435376877304746 1.26363898778024 0.368421052631579 22.4 22 4 Leydig cell hypoplasia 0.115342055133197 0.435376877304746 1.26363898778024 0.368421052631579 22.4 22 4 right-sided stomach 0.115342055133197 0.435376877304746 1.26363898778024 0.368421052631579 22.4 22 4 abnormal craniofacial bone morphology 0.0103293784935756 0.0941184212555649 1.26363898778024 0.368421052631579 22.4 22 4 abnormal retinal pigmentation 0.00187293231042057 0.0279442079527094 1.2615640469136 0.367816091954023 22.4 22 4 absent kidney 0.0173804714803326 0.1339648179136 1.25995490909866 0.36734693877551 22.4 22 4 abnormal renal glomerulus morphology 0.000579969502478021 0.010662809206643 1.25867055139316 0.36697247706422 22.4 22 4 kyphosis 6.33139163837281e-05 0.00177239368743592 1.257621659267 0.366666666666667 22.4 22 4 decreased T cell number 3.57537140295714e-05 0.00111171704560698 1.25691153975301 0.366459627329193 22.4 22 4 enlarged heart 8.08779577249344e-07 4.28050893278243e-05 1.25663606235535 0.366379310344828 22.4 22 4 liver fibrosis 0.0295576387287646 0.192472843816236 1.2548331411755 0.365853658536585 22.4 22 4 palatal shelves fail to meet at midline 0.0295576387287646 0.192472843816236 1.2548331411755 0.365853658536585 22.4 22 4 retinal degeneration 0.00141119567037295 0.0220030041240941 1.25047608165753 0.364583333333333 22.4 22 4 increased circulating alkaline phosphatase level 4.39677000572906e-05 0.0012941810209444 1.24915282654466 0.364197530864198 22.4 22 4 male infertility 1.14073455441825e-12 1.89171813607693e-10 1.24784798651289 0.363817097415507 22.4 22 4 decreased circulating calcium level 0.0141868917072478 0.114577575070711 1.24722809183504 0.363636363636364 22.4 22 4 abnormal contextual conditioning behavior 0.0141868917072478 0.114577575070711 1.24722809183504 0.363636363636364 22.4 22 4 abnormal tooth development 0.0510282074557947 0.251103196926389 1.24722809183504 0.363636363636364 22.4 22 4 decreased systemic arterial blood pressure 0.0510282074557947 0.251103196926389 1.24722809183504 0.363636363636364 22.4 22 4 dilated heart atrium 0.0510282074557947 0.251103196926389 1.24722809183504 0.363636363636364 22.4 22 4 abnormal QRS complex 0.0510282074557947 0.251103196926389 1.24722809183504 0.363636363636364 22.4 22 4 cardiovascular system phenotype 0.0510282074557947 0.251103196926389 1.24722809183504 0.363636363636364 22.4 22 4 abnormal abdominal fat pad morphology 0.101844932255744 0.395761434604275 1.24722809183504 0.363636363636364 22.4 22 4 abnormal oogenesis 0.101844932255744 0.395761434604275 1.24722809183504 0.363636363636364 22.4 22 4 abnormal cochlear sensory epithelium morphology 0.101844932255744 0.395761434604275 1.24722809183504 0.363636363636364 22.4 22 4 decreased cardiac output 0.101844932255744 0.395761434604275 1.24722809183504 0.363636363636364 22.4 22 4 parakeratosis 0.101844932255744 0.395761434604275 1.24722809183504 0.363636363636364 22.4 22 4 prolonged PR interval 0.101844932255744 0.395761434604275 1.24722809183504 0.363636363636364 22.4 22 4 failure of palatal shelf elevation 0.101844932255744 0.395761434604275 1.24722809183504 0.363636363636364 22.4 22 4 pulmonary vascular congestion 0.101844932255744 0.395761434604275 1.24722809183504 0.363636363636364 22.4 22 4 rough coat 0.101844932255744 0.395761434604275 1.24722809183504 0.363636363636364 22.4 22 4 impaired humoral immune response 0.101844932255744 0.395761434604275 1.24722809183504 0.363636363636364 22.4 22 4 impaired balance 0.00116726807075457 0.018915826228026 1.2441711602374 0.362745098039216 22.4 22 4 abnormal B cell differentiation 0.00210304609509513 0.029893298065995 1.24380164103329 0.362637362637363 22.4 22 4 abnormal locomotor activation 0.00210304609509513 0.029893298065995 1.24380164103329 0.362637362637363 22.4 22 4 abnormal posture 0.0038104068927497 0.0469227086421528 1.24333050404805 0.3625 22.4 22 4 decreased spleen weight 0.00695433971694279 0.0723804186020719 1.24270914947332 0.36231884057971 22.4 22 4 abnormal spermiogenesis 0.0128165624340687 0.10627066351582 1.24185210868058 0.362068965517241 22.4 22 4 thrombocytosis 0.0128165624340687 0.10627066351582 1.24185210868058 0.362068965517241 22.4 22 4 no abnormal phenotype detected 1.00594285512244e-39 1.66818856807804e-36 1.23950030970984 0.361383285302594 22.4 22 4 abnormal lung morphology 0.000538830425158035 0.0101157787364574 1.23936741058398 0.361344537815126 22.4 22 4 heart right ventricle hypertrophy 0.0456649705963703 0.249926544243061 1.23856678564174 0.361111111111111 22.4 22 4 abnormal male meiosis 0.0115787873656089 0.0996617078614259 1.23700491075442 0.360655737704918 22.4 22 4 abnormal kidney morphology 3.71862896626759e-05 0.00114907944765101 1.23475581091669 0.36 22.4 22 4 testicular atrophy 0.0215587436251815 0.155216714233398 1.23475581091669 0.36 22.4 22 4 abnormal nest building behavior 0.0901371586845032 0.360766182184556 1.23475581091669 0.36 22.4 22 4 abnormal heart looping 0.0408927443902435 0.229358966563091 1.23123798809356 0.358974358974359 22.4 22 4 small lens 0.0408927443902435 0.229358966563091 1.23123798809356 0.358974358974359 22.4 22 4 impaired macrophage chemotaxis 0.0408927443902435 0.229358966563091 1.23123798809356 0.358974358974359 22.4 22 4 impaired glucose tolerance 1.25529831893506e-06 6.43825684196074e-05 1.23088336885736 0.358870967741935 22.4 22 4 abnormal spermatogenesis 2.81245274010532e-05 0.000920523183027891 1.23028205797858 0.358695652173913 22.4 22 4 abnormal coat/ hair morphology 0.0194145858998312 0.145742101754678 1.2295786377053 0.358490566037736 22.4 22 4 decreased white adipose tissue amount 0.00945188383799748 0.0897387826222089 1.22861274718078 0.358208955223881 22.4 22 4 hypoactivity 3.17149093737795e-09 2.97701271951987e-07 1.22820538221156 0.358090185676393 22.4 22 4 decreased heart weight 0.00467580574335709 0.054350779376639 1.22798074473882 0.358024691358025 22.4 22 4 hydronephrosis 0.00423399997868923 0.0508795891158911 1.2249561616237 0.357142857142857 22.4 22 4 abnormal cartilage morphology 0.0366431519415938 0.217694014241488 1.2249561616237 0.357142857142857 22.4 22 4 abnormal optic nerve morphology 0.0366431519415938 0.217694014241488 1.2249561616237 0.357142857142857 22.4 22 4 abnormal vibrissa morphology 0.0366431519415938 0.217694014241488 1.2249561616237 0.357142857142857 22.4 22 4 shortened head 0.0799379724896162 0.336296110969262 1.2249561616237 0.357142857142857 22.4 22 4 abnormal somite shape 0.0799379724896162 0.336296110969262 1.2249561616237 0.357142857142857 22.4 22 4 failure of blastocyst to hatch from the zona pellucida 0.0799379724896162 0.336296110969262 1.2249561616237 0.357142857142857 22.4 22 4 abnormal retinal inner nuclear layer morphology 0.0799379724896162 0.336296110969262 1.2249561616237 0.357142857142857 22.4 22 4 abnormal hormone level 0.0799379724896162 0.336296110969262 1.2249561616237 0.357142857142857 22.4 22 4 increased bone resorption 0.0799379724896162 0.336296110969262 1.2249561616237 0.357142857142857 22.4 22 4 increased triglyceride level 0.0799379724896162 0.336296110969262 1.2249561616237 0.357142857142857 22.4 22 4 abnormal renal tubule epithelium morphology 0.0799379724896162 0.336296110969262 1.2249561616237 0.357142857142857 22.4 22 4 midline facial cleft 0.191080933664326 0.540190451462707 1.2249561616237 0.357142857142857 22.4 22 4 abnormal blood flow velocity 0.191080933664326 0.540190451462707 1.2249561616237 0.357142857142857 22.4 22 4 abnormal zigzag hair morphology 0.191080933664326 0.540190451462707 1.2249561616237 0.357142857142857 22.4 22 4 increased aggression towards males 0.191080933664326 0.540190451462707 1.2249561616237 0.357142857142857 22.4 22 4 abnormal placing response 0.191080933664326 0.540190451462707 1.2249561616237 0.357142857142857 22.4 22 4 absent olfactory bulb 0.191080933664326 0.540190451462707 1.2249561616237 0.357142857142857 22.4 22 4 abnormal hair cuticle 0.191080933664326 0.540190451462707 1.2249561616237 0.357142857142857 22.4 22 4 abnormal sagittal suture morphology 0.191080933664326 0.540190451462707 1.2249561616237 0.357142857142857 22.4 22 4 abnormal decidualization 0.191080933664326 0.540190451462707 1.2249561616237 0.357142857142857 22.4 22 4 abnormal maternal decidual layer morphology 0.191080933664326 0.540190451462707 1.2249561616237 0.357142857142857 22.4 22 4 increased circulating growth hormone level 0.191080933664326 0.540190451462707 1.2249561616237 0.357142857142857 22.4 22 4 abnormal viscerocranium morphology 0.191080933664326 0.540190451462707 1.2249561616237 0.357142857142857 22.4 22 4 abnormal glucose tolerance 0.191080933664326 0.540190451462707 1.2249561616237 0.357142857142857 22.4 22 4 decreased compact bone area 0.191080933664326 0.540190451462707 1.2249561616237 0.357142857142857 22.4 22 4 testis degeneration 0.191080933664326 0.540190451462707 1.2249561616237 0.357142857142857 22.4 22 4 abnormal testis morphology 0.00097203786385845 0.016119627908986 1.22282580308174 0.356521739130435 22.4 22 4 seminiferous tubule degeneration 0.00771835086286479 0.0785251442592072 1.22160011734528 0.356164383561644 22.4 22 4 decreased percent body fat/body weight 0.00771835086286479 0.0785251442592072 1.22160011734528 0.356164383561644 22.4 22 4 decreased osteoclast cell number 0.0328557987561364 0.204577720665555 1.21951191201648 0.355555555555556 22.4 22 4 lethargy 0.00314421314905499 0.0394016635177546 1.21705321864548 0.354838709677419 22.4 22 4 abnormal capillary morphology 0.0710195471678387 0.325018581112913 1.21705321864548 0.354838709677419 22.4 22 4 abnormal T cell proliferation 0.0710195471678387 0.325018581112913 1.21705321864548 0.354838709677419 22.4 22 4 abnormal developmental patterning 0.00570025370927273 0.0633008084902496 1.21300536980298 0.353658536585366 22.4 22 4 abnormal motor coordination/ balance 0.00257899267591356 0.0339765449559825 1.21258286706184 0.353535353535354 22.4 22 4 abnormal neuron morphology 0.00257899267591356 0.0339765449559825 1.21258286706184 0.353535353535354 22.4 22 4 neonatal lethality, complete penetrance 3.41713230278432e-10 3.77782960141156e-08 1.21098736328939 0.353070175438596 22.4 22 4 short maxilla 0.0631954874312909 0.293829485953899 1.21054491266342 0.352941176470588 22.4 22 4 decreased osteoblast cell number 0.0631954874312909 0.293829485953899 1.21054491266342 0.352941176470588 22.4 22 4 abnormal adipose tissue morphology 0.165623007359572 0.531939613695204 1.21054491266342 0.352941176470588 22.4 22 4 hyperlipidemia 0.165623007359572 0.531939613695204 1.21054491266342 0.352941176470588 22.4 22 4 abnormal dorsal-ventral axis patterning 0.165623007359572 0.531939613695204 1.21054491266342 0.352941176470588 22.4 22 4 abnormal duodenum morphology 0.165623007359572 0.531939613695204 1.21054491266342 0.352941176470588 22.4 22 4 abnormal testis development 0.165623007359572 0.531939613695204 1.21054491266342 0.352941176470588 22.4 22 4 increased regulatory T cell number 0.165623007359572 0.531939613695204 1.21054491266342 0.352941176470588 22.4 22 4 abnormal ectoplacental cone morphology 0.165623007359572 0.531939613695204 1.21054491266342 0.352941176470588 22.4 22 4 enhanced behavioral response to cocaine 0.165623007359572 0.531939613695204 1.21054491266342 0.352941176470588 22.4 22 4 common atrium 0.165623007359572 0.531939613695204 1.21054491266342 0.352941176470588 22.4 22 4 abnormal cell cytoskeleton morphology 0.165623007359572 0.531939613695204 1.21054491266342 0.352941176470588 22.4 22 4 reduced fertility 0.000448172423965837 0.00860871741015458 1.20909341996238 0.352517985611511 22.4 22 4 increased heart weight 0.000448172423965837 0.00860871741015458 1.20909341996238 0.352517985611511 22.4 22 4 abnormal mandible morphology 0.0237670073478962 0.165371834343753 1.20680866293298 0.351851851851852 22.4 22 4 impaired limb coordination 0.0237670073478962 0.165371834343753 1.20680866293298 0.351851851851852 22.4 22 4 abnormal neuronal precursor proliferation 0.0237670073478962 0.165371834343753 1.20680866293298 0.351851851851852 22.4 22 4 decreased IgG level 0.00173630361866116 0.0265788015471977 1.20509200765142 0.351351351351351 22.4 22 4 decreased circulating chloride level 0.0563118952832989 0.265798556958645 1.20509200765142 0.351351351351351 22.4 22 4 abnormal pancreatic beta cell physiology 0.0563118952832989 0.265798556958645 1.20509200765142 0.351351351351351 22.4 22 4 decreased brain weight 0.0213575872540733 0.154214799113229 1.20346570264784 0.350877192982456 22.4 22 4 increased monocyte cell number 0.00311933019223362 0.0391885548140461 1.20045703839122 0.35 22.4 22 4 abnormal cell proliferation 0.144464051787112 0.475650997776891 1.20045703839122 0.35 22.4 22 4 brain inflammation 0.144464051787112 0.475650997776891 1.20045703839122 0.35 22.4 22 4 abnormal hair texture 0.144464051787112 0.475650997776891 1.20045703839122 0.35 22.4 22 4 decreased myocardial infarction size 0.144464051787112 0.475650997776891 1.20045703839122 0.35 22.4 22 4 absent placental labyrinth 0.144464051787112 0.475650997776891 1.20045703839122 0.35 22.4 22 4 abnormal thymocyte activation 0.144464051787112 0.475650997776891 1.20045703839122 0.35 22.4 22 4 skin lesions 0.0172709715230379 0.1339648179136 1.19773491358762 0.349206349206349 22.4 22 4 increased circulating aspartate transaminase level 0.0172709715230379 0.1339648179136 1.19773491358762 0.349206349206349 22.4 22 4 abnormal homeostasis 0.0448739285128451 0.248605561638535 1.1964688090278 0.348837209302326 22.4 22 4 impaired macrophage phagocytosis 0.0448739285128451 0.248605561638535 1.1964688090278 0.348837209302326 22.4 22 4 delayed endochondral bone ossification 0.0448739285128451 0.248605561638535 1.1964688090278 0.348837209302326 22.4 22 4 weight loss 0.000140367271624299 0.00332536750633755 1.19555721374473 0.348571428571429 22.4 22 4 insulin resistance 0.000870944136158475 0.014687956194537 1.19526025467525 0.348484848484849 22.4 22 4 abnormal tail morphology 0.0155410602154146 0.121517958540052 1.19526025467525 0.348484848484849 22.4 22 4 abnormal immune system morphology 0.0401209139520086 0.226819939671867 1.19300078349438 0.347826086956522 22.4 22 4 abnormal lymphocyte physiology 0.0401209139520086 0.226819939671867 1.19300078349438 0.347826086956522 22.4 22 4 abnormal neurocranium morphology 0.0113494736451306 0.0991540479884161 1.18902411421607 0.346666666666667 22.4 22 4 cachexia 0.00339305574840174 0.0424131968550217 1.18726520280451 0.346153846153846 22.4 22 4 abnormal skin condition 0.0321571778695027 0.204014094416122 1.18726520280451 0.346153846153846 22.4 22 4 abnormal hair growth 0.0321571778695027 0.204014094416122 1.18726520280451 0.346153846153846 22.4 22 4 abnormal Schwann cell morphology 0.111393016076703 0.424842340330022 1.18726520280451 0.346153846153846 22.4 22 4 abnormal ocular fundus morphology 0.111393016076703 0.424842340330022 1.18726520280451 0.346153846153846 22.4 22 4 decreased Peyer's patch number 0.111393016076703 0.424842340330022 1.18726520280451 0.346153846153846 22.4 22 4 abnormal cornea morphology 0.0102277101922206 0.0933630425803627 1.18726520280451 0.346153846153846 22.4 22 4 increased urine protein level 0.0102277101922206 0.0933630425803627 1.18726520280451 0.346153846153846 22.4 22 4 increased circulating triglyceride level 0.000703090755236204 0.0122732509028074 1.1827162939815 0.344827586206897 22.4 22 4 abnormal middle ear morphology 0.098304836359186 0.390316489135635 1.1827162939815 0.344827586206897 22.4 22 4 abnormal parietal bone morphology 0.098304836359186 0.390316489135635 1.1827162939815 0.344827586206897 22.4 22 4 abnormal microglial cell morphology 0.098304836359186 0.390316489135635 1.1827162939815 0.344827586206897 22.4 22 4 abnormal outer ear morphology 0.098304836359186 0.390316489135635 1.1827162939815 0.344827586206897 22.4 22 4 abnormal CD8-positive, alpha-beta T cell physiology 0.098304836359186 0.390316489135635 1.1827162939815 0.344827586206897 22.4 22 4 hypoglycemia 0.00610566959454175 0.0662134390244153 1.18017281808047 0.344086021505376 22.4 22 4 abnormal depression-related behavior 0.0869779294077181 0.351800974636909 1.17902030556281 0.34375 22.4 22 4 abnormal auditory brainstem response waveform shape 0.0869779294077181 0.351800974636909 1.17902030556281 0.34375 22.4 22 4 maternal effect 0.0187240387763371 0.141568530261819 1.17742054938159 0.343283582089552 22.4 22 4 abnormal intestinal goblet cell morphology 0.0771239455541376 0.336296110969262 1.17595791515875 0.342857142857143 22.4 22 4 decreased triglyceride level 0.0771239455541376 0.336296110969262 1.17595791515875 0.342857142857143 22.4 22 4 decreased glycogen level 0.0771239455541376 0.336296110969262 1.17595791515875 0.342857142857143 22.4 22 4 decreased bone mineralization 0.0771239455541376 0.336296110969262 1.17595791515875 0.342857142857143 22.4 22 4 abnormal retinal outer nuclear layer morphology 0.0685144202781014 0.314736141166717 1.17337906008165 0.342105263157895 22.4 22 4 decreased startle reflex 0.00270777161077832 0.0353573852063573 1.17260760770816 0.341880341880342 22.4 22 4 ataxia 0.000109229403937825 0.00267692751029891 1.17159173478069 0.341584158415842 22.4 22 4 lethality at weaning, incomplete penetrance 0.0609650751743809 0.285623501997809 1.17117759843046 0.341463414634146 22.4 22 4 cardiac fibrosis 0.0099500565414001 0.0916296744446171 1.17019341557464 0.341176470588235 22.4 22 4 abnormal myelopoiesis 0.0543251029317181 0.259125011587054 1.16927633609535 0.340909090909091 22.4 22 4 small ovary 0.00808368466295075 0.0795215143760735 1.16841972339491 0.340659340659341 22.4 22 4 pulmonary hypoplasia 0.0484696071422125 0.251103196926389 1.16761778810089 0.340425531914894 22.4 22 4 decreased IgM level 0.00657545816899626 0.0694541494495889 1.16686545705185 0.34020618556701 22.4 22 4 decreased heart rate 0.00593289009578812 0.0650134982963566 1.16615826586576 0.34 22.4 22 4 increased body length 0.0432941168803019 0.240926433422262 1.16615826586576 0.34 22.4 22 4 azoospermia 0.000668838669249261 0.0118415387171355 1.16486397256291 0.339622641509434 22.4 22 4 abnormal coat/hair pigmentation 0.00394185300733404 0.0484215276826836 1.16370835354251 0.339285714285714 22.4 22 4 female infertility 1.67690505009239e-05 0.000587507227057017 1.16048478469614 0.338345864661654 22.4 22 4 increased circulating free fatty acid level 0.0201125752445685 0.149566609628892 1.1593951276213 0.338028169014085 22.4 22 4 decreased rib number 0.0106632072116826 0.0957571405742253 1.15613839973473 0.337078651685393 22.4 22 4 hyperactivity 5.70491716311835e-07 3.15355143183486e-05 1.15561902039972 0.336927223719677 22.4 22 4 abnormal gait 5.08684252830151e-06 0.0002108920131525 1.1543923438991 0.336569579288026 22.4 22 4 abnormal dendritic cell physiology 0.00572912767953423 0.0634797554692267 1.15397739338008 0.336448598130841 22.4 22 4 increased sensitivity to xenobiotic induced morbidity/mortality 0.00517074685271038 0.0595473740560975 1.15368598494741 0.336363636363636 22.4 22 4 abnormal cranium morphology 0.00229453983628669 0.0317092657931285 1.15182445048199 0.335820895522388 22.4 22 4 increased or absent threshold for auditory brainstem response 1.17612360002841e-05 0.000453582551173748 1.15120447576815 0.335640138408304 22.4 22 4 reduced male fertility 0.00010653152049585 0.00264955058815594 1.14832894798909 0.334801762114537 22.4 22 4 diluted coat color 0.0461822626497666 0.251103196926389 1.14329241751545 0.333333333333333 22.4 22 4 dextrocardia 0.10495279038368 0.407285594507651 1.14329241751545 0.333333333333333 22.4 22 4 rectal prolapse 0.135167886468736 0.448605894050674 1.14329241751545 0.333333333333333 22.4 22 4 thick interventricular septum 0.135167886468736 0.448605894050674 1.14329241751545 0.333333333333333 22.4 22 4 microphthalmia 0.00147725105298894 0.022823987542298 1.14329241751545 0.333333333333333 22.4 22 4 abnormal blood homeostasis 0.00550419154387279 0.062093770818066 1.14329241751545 0.333333333333333 22.4 22 4 increased circulating HDL cholesterol level 0.00749445598231047 0.0768761206432879 1.14329241751545 0.333333333333333 22.4 22 4 abnormal neuromuscular synapse morphology 0.02386960347708 0.165466842716402 1.14329241751545 0.333333333333333 22.4 22 4 abnormal sternum morphology 0.0265966509826295 0.17618953214192 1.14329241751545 0.333333333333333 22.4 22 4 abnormal hair follicle morphology 0.0330868165273687 0.205758640279574 1.14329241751545 0.333333333333333 22.4 22 4 abnormal kidney development 0.0369447732878091 0.217694014241488 1.14329241751545 0.333333333333333 22.4 22 4 impaired natural killer cell mediated cytotoxicity 0.0412870963231231 0.231049836003979 1.14329241751545 0.333333333333333 22.4 22 4 increased macrophage cell number 0.0412870963231231 0.231049836003979 1.14329241751545 0.333333333333333 22.4 22 4 abnormal cued conditioning behavior 0.0517103660183071 0.251873123585624 1.14329241751545 0.333333333333333 22.4 22 4 abnormal cardiovascular system morphology 0.0579656464855679 0.273086260668277 1.14329241751545 0.333333333333333 22.4 22 4 abnormal pancreas morphology 0.0731260367907745 0.330750100760296 1.14329241751545 0.333333333333333 22.4 22 4 abnormal muscle morphology 0.0731260367907745 0.330750100760296 1.14329241751545 0.333333333333333 22.4 22 4 abnormal reproductive system morphology 0.0731260367907745 0.330750100760296 1.14329241751545 0.333333333333333 22.4 22 4 abnormal spleen white pulp morphology 0.0731260367907745 0.330750100760296 1.14329241751545 0.333333333333333 22.4 22 4 abnormal leukocyte adhesion 0.0823252582220304 0.337155009820403 1.14329241751545 0.333333333333333 22.4 22 4 decreased B-1 B cell number 0.0823252582220304 0.337155009820403 1.14329241751545 0.333333333333333 22.4 22 4 abnormal uterus morphology 0.092853433033021 0.370743041203274 1.14329241751545 0.333333333333333 22.4 22 4 renal hypoplasia 0.092853433033021 0.370743041203274 1.14329241751545 0.333333333333333 22.4 22 4 salivary gland inflammation 0.118927608454707 0.441914998237266 1.14329241751545 0.333333333333333 22.4 22 4 abnormal spleen marginal zone morphology 0.118927608454707 0.441914998237266 1.14329241751545 0.333333333333333 22.4 22 4 abnormal synaptic transmission 0.118927608454707 0.441914998237266 1.14329241751545 0.333333333333333 22.4 22 4 abnormal adrenal gland morphology 0.154186252883453 0.501685158989652 1.14329241751545 0.333333333333333 22.4 22 4 abnormal body weight 0.154186252883453 0.501685158989652 1.14329241751545 0.333333333333333 22.4 22 4 abnormal vasodilation 0.154186252883453 0.501685158989652 1.14329241751545 0.333333333333333 22.4 22 4 prolonged QT interval 0.154186252883453 0.501685158989652 1.14329241751545 0.333333333333333 22.4 22 4 hypopigmentation 0.154186252883453 0.501685158989652 1.14329241751545 0.333333333333333 22.4 22 4 abnormal cellular extravasation 0.154186252883453 0.501685158989652 1.14329241751545 0.333333333333333 22.4 22 4 abnormal truncus arteriosus septation 0.154186252883453 0.501685158989652 1.14329241751545 0.333333333333333 22.4 22 4 lowered ear position 0.203629650087133 0.540190451462707 1.14329241751545 0.333333333333333 22.4 22 4 abnormal scapula morphology 0.176678530405532 0.540190451462707 1.14329241751545 0.333333333333333 22.4 22 4 abnormal salivary gland morphology 0.176678530405532 0.540190451462707 1.14329241751545 0.333333333333333 22.4 22 4 abnormal retinal rod cell morphology 0.203629650087133 0.540190451462707 1.14329241751545 0.333333333333333 22.4 22 4 blepharoptosis 0.203629650087133 0.540190451462707 1.14329241751545 0.333333333333333 22.4 22 4 trunk curl 0.176678530405532 0.540190451462707 1.14329241751545 0.333333333333333 22.4 22 4 abnormal white adipose tissue morphology 0.203629650087133 0.540190451462707 1.14329241751545 0.333333333333333 22.4 22 4 long tibia 0.203629650087133 0.540190451462707 1.14329241751545 0.333333333333333 22.4 22 4 increased acute inflammation 0.176678530405532 0.540190451462707 1.14329241751545 0.333333333333333 22.4 22 4 abnormal clavicle morphology 0.176678530405532 0.540190451462707 1.14329241751545 0.333333333333333 22.4 22 4 jerky movement 0.203629650087133 0.540190451462707 1.14329241751545 0.333333333333333 22.4 22 4 decreased pulmonary respiratory rate 0.203629650087133 0.540190451462707 1.14329241751545 0.333333333333333 22.4 22 4 increased keratinocyte proliferation 0.176678530405532 0.540190451462707 1.14329241751545 0.333333333333333 22.4 22 4 embryonic lethality at implantation, complete penetrance 0.176678530405532 0.540190451462707 1.14329241751545 0.333333333333333 22.4 22 4 increased bone ossification 0.176678530405532 0.540190451462707 1.14329241751545 0.333333333333333 22.4 22 4 absent incisors 0.236514570709623 0.56191976565443 1.14329241751545 0.333333333333333 22.4 22 4 decreased hepatocyte number 0.236514570709623 0.56191976565443 1.14329241751545 0.333333333333333 22.4 22 4 vagina atresia 0.236514570709623 0.56191976565443 1.14329241751545 0.333333333333333 22.4 22 4 abnormal pup retrieval 0.236514570709623 0.56191976565443 1.14329241751545 0.333333333333333 22.4 22 4 audiogenic seizures 0.236514570709623 0.56191976565443 1.14329241751545 0.333333333333333 22.4 22 4 placental labyrinth hypoplasia 0.236514570709623 0.56191976565443 1.14329241751545 0.333333333333333 22.4 22 4 increased airway responsiveness 0.236514570709623 0.56191976565443 1.14329241751545 0.333333333333333 22.4 22 4 abnormal respiratory system morphology 0.236514570709623 0.56191976565443 1.14329241751545 0.333333333333333 22.4 22 4 abnormal bronchus morphology 0.236514570709623 0.56191976565443 1.14329241751545 0.333333333333333 22.4 22 4 abnormal ear development 0.236514570709623 0.56191976565443 1.14329241751545 0.333333333333333 22.4 22 4 abnormal zygomatic bone morphology 0.236514570709623 0.56191976565443 1.14329241751545 0.333333333333333 22.4 22 4 abnormal cerebral aqueduct morphology 0.236514570709623 0.56191976565443 1.14329241751545 0.333333333333333 22.4 22 4 abnormal secondary palate development 0.236514570709623 0.56191976565443 1.14329241751545 0.333333333333333 22.4 22 4 bicuspid aortic valve 0.236514570709623 0.56191976565443 1.14329241751545 0.333333333333333 22.4 22 4 decreased brown adipose tissue mass 0.236514570709623 0.56191976565443 1.14329241751545 0.333333333333333 22.4 22 4 postnatal lethality, complete penetrance 1.09513102173602e-06 5.67528836785071e-05 1.13736862260605 0.33160621761658 22.4 22 4 abnormal cytokine secretion 0.00173108754584681 0.0265788015471977 1.13586844077834 0.331168831168831 22.4 22 4 abnormal cardiovascular system physiology 0.00350476013435892 0.0435904541710891 1.13469623392511 0.330827067669173 22.4 22 4 hydroencephaly 0.00646325276574228 0.0690014646128065 1.13335074431967 0.330434782608696 22.4 22 4 increased body weight 0.000207270824702206 0.0046871470586067 1.13308444950192 0.330357142857143 22.4 22 4 small kidney 0.0164900003764445 0.128585817982463 1.1303004582255 0.329545454545455 22.4 22 4 abnormal retina morphology 0.000394519261215199 0.00778862430375243 1.1269596686938 0.328571428571429 22.4 22 4 decreased compact bone thickness 0.0349980981333077 0.212077391246292 1.12622835158239 0.328358208955224 22.4 22 4 abnormal learning/memory/conditioning 0.0546272220240236 0.260316503419078 1.12250528265153 0.327272727272727 22.4 22 4 abnormal snout morphology 0.0612076288334407 0.285623501997809 1.12130602487092 0.326923076923077 22.4 22 4 impaired coordination 9.85334169414941e-06 0.000382971679128073 1.12016222409751 0.326589595375723 22.4 22 4 abnormal respiratory system physiology 0.0686621587338133 0.315123837362289 1.11995991919881 0.326530612244898 22.4 22 4 abnormal locomotor behavior 0.0173708319468686 0.1339648179136 1.11843823452599 0.326086956521739 22.4 22 4 abnormal forelimb morphology 0.0771269361812026 0.336296110969262 1.11843823452599 0.326086956521739 22.4 22 4 abnormal rib morphology 0.00477134463164952 0.0553320269054927 1.11788591934844 0.325925925925926 22.4 22 4 increased oxygen consumption 0.021466842387923 0.154779044753503 1.11670422175928 0.325581395348837 22.4 22 4 short tail 0.0238804408181662 0.165466842716402 1.11574320263556 0.325301204819277 22.4 22 4 abnormal lipid level 0.0238804408181662 0.165466842716402 1.11574320263556 0.325301204819277 22.4 22 4 decreased anxiety-related response 0.00717161181671467 0.0737164644383378 1.11540723660044 0.32520325203252 22.4 22 4 abnormal spatial learning 0.00223875719704657 0.0311983671016994 1.1152361618709 0.325153374233129 22.4 22 4 increased B cell number 0.00880436505370158 0.0855502268401668 1.11397722732275 0.324786324786325 22.4 22 4 decreased width of hypertrophic chondrocyte zone 0.110393371152888 0.424842340330022 1.11239262244747 0.324324324324324 22.4 22 4 abnormal hair follicle development 0.110393371152888 0.424842340330022 1.11239262244747 0.324324324324324 22.4 22 4 abnormal glucose homeostasis 0.00142678155735963 0.0221128917378946 1.11188328516613 0.324175824175824 22.4 22 4 corneal opacity 0.0367709481005228 0.217694014241488 1.11108699730375 0.323943661971831 22.4 22 4 overexpanded pulmonary alveoli 0.124923674404388 0.441914998237266 1.10966616994147 0.323529411764706 22.4 22 4 thin skin 0.124923674404388 0.441914998237266 1.10966616994147 0.323529411764706 22.4 22 4 impaired synaptic plasticity 0.124923674404388 0.441914998237266 1.10966616994147 0.323529411764706 22.4 22 4 abnormal vision 0.124923674404388 0.441914998237266 1.10966616994147 0.323529411764706 22.4 22 4 decreased cytotoxic T cell cytolysis 0.124923674404388 0.441914998237266 1.10966616994147 0.323529411764706 22.4 22 4 osteopetrosis 0.141740970972263 0.468857267677533 1.10641201695044 0.32258064516129 22.4 22 4 increased B cell proliferation 0.0572499205679134 0.269970004573809 1.10453674234544 0.322033898305085 22.4 22 4 abnormal nervous system physiology 0.0113223604423158 0.0991540479884161 1.10352572473231 0.321739130434783 22.4 22 4 abnormal eye development 0.0640929935248264 0.296892591048428 1.10246054546133 0.321428571428571 22.4 22 4 myoclonus 0.161329424669371 0.521855583699689 1.10246054546133 0.321428571428571 22.4 22 4 abnormal jaw morphology 0.161329424669371 0.521855583699689 1.10246054546133 0.321428571428571 22.4 22 4 reddish skin 0.161329424669371 0.521855583699689 1.10246054546133 0.321428571428571 22.4 22 4 increased total body fat amount 0.00709124791056173 0.0734226048383749 1.10063225268279 0.32089552238806 22.4 22 4 decreased litter size 0.00016073942938855 0.00373681617386933 1.09853719832446 0.320284697508897 22.4 22 4 abnormal limb morphology 0.038412668302813 0.218154137906958 1.09756072081483 0.32 22.4 22 4 abnormal hindlimb morphology 0.0806000607825246 0.337155009820403 1.09756072081483 0.32 22.4 22 4 increased pre-B cell number 0.184327003094723 0.540190451462707 1.09756072081483 0.32 22.4 22 4 diaphragmatic hernia 0.184327003094723 0.540190451462707 1.09756072081483 0.32 22.4 22 4 increased systemic arterial blood pressure 0.090560059168229 0.3621674391977 1.09464167634458 0.319148936170213 22.4 22 4 hyperkeratosis 0.0477800685854677 0.251103196926389 1.09358405153652 0.318840579710145 22.4 22 4 abnormal coat appearance 0.0477800685854677 0.251103196926389 1.09358405153652 0.318840579710145 22.4 22 4 abnormal skin morphology 0.0533453166605109 0.254940394222903 1.09132458035566 0.318181818181818 22.4 22 4 hypertension 0.101903597533282 0.395761434604275 1.09132458035566 0.318181818181818 22.4 22 4 abnormal astrocyte morphology 0.101903597533282 0.395761434604275 1.09132458035566 0.318181818181818 22.4 22 4 renal interstitial fibrosis 0.101903597533282 0.395761434604275 1.09132458035566 0.318181818181818 22.4 22 4 cochlear hair cell degeneration 0.101903597533282 0.395761434604275 1.09132458035566 0.318181818181818 22.4 22 4 abnormal basisphenoid bone morphology 0.211600876208766 0.540190451462707 1.09132458035566 0.318181818181818 22.4 22 4 abnormal enterocyte morphology 0.211600876208766 0.540190451462707 1.09132458035566 0.318181818181818 22.4 22 4 abnormal chorion morphology 0.211600876208766 0.540190451462707 1.09132458035566 0.318181818181818 22.4 22 4 increased coping response 0.211600876208766 0.540190451462707 1.09132458035566 0.318181818181818 22.4 22 4 abnormal retinal layer morphology 0.211600876208766 0.540190451462707 1.09132458035566 0.318181818181818 22.4 22 4 abnormal circulating lipid level 0.211600876208766 0.540190451462707 1.09132458035566 0.318181818181818 22.4 22 4 abnormal limb posture 0.211600876208766 0.540190451462707 1.09132458035566 0.318181818181818 22.4 22 4 abnormal temporal bone morphology 0.211600876208766 0.540190451462707 1.09132458035566 0.318181818181818 22.4 22 4 increased neutrophil cell number 0.00694425846440142 0.0723804186020719 1.08809899046298 0.317241379310345 22.4 22 4 arrested B cell differentiation 0.114863029713068 0.435376877304746 1.08752205568543 0.317073170731707 22.4 22 4 abnormal incisor morphology 0.0666596229660105 0.308494534191537 1.08612779663968 0.316666666666667 22.4 22 4 hunched posture 0.039930761957729 0.226259158017883 1.08540419384378 0.316455696202532 22.4 22 4 decreased birth weight 0.027067250612172 0.179068579515366 1.08311913238306 0.315789473684211 22.4 22 4 increased grooming behavior 0.129722117710481 0.441914998237266 1.08311913238306 0.315789473684211 22.4 22 4 abnormal triglyceride level 0.244377770835103 0.577293167096219 1.08311913238306 0.315789473684211 22.4 22 4 thin dermal layer 0.244377770835103 0.577293167096219 1.08311913238306 0.315789473684211 22.4 22 4 abnormal neurotransmitter level 0.244377770835103 0.577293167096219 1.08311913238306 0.315789473684211 22.4 22 4 abnormal neural crest cell migration 0.244377770835103 0.577293167096219 1.08311913238306 0.315789473684211 22.4 22 4 increased susceptibility to ischemic brain injury 0.244377770835103 0.577293167096219 1.08311913238306 0.315789473684211 22.4 22 4 eyelids fail to open 0.244377770835103 0.577293167096219 1.08311913238306 0.315789473684211 22.4 22 4 decreased fertilization frequency 0.244377770835103 0.577293167096219 1.08311913238306 0.315789473684211 22.4 22 4 decreased circulating magnesium level 0.244377770835103 0.577293167096219 1.08311913238306 0.315789473684211 22.4 22 4 increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 0.244377770835103 0.577293167096219 1.08311913238306 0.315789473684211 22.4 22 4 abnormal cochlea morphology 0.0836159459380909 0.339306142774879 1.07977617209793 0.314814814814815 22.4 22 4 abnormal immune system physiology 0.0140921600933125 0.114371529052779 1.07875171652668 0.314516129032258 22.4 22 4 abnormal dermal layer morphology 0.146831883460752 0.482808076812454 1.07796142222885 0.314285714285714 22.4 22 4 abnormal intestinal epithelium morphology 0.105375701296712 0.407972073113727 1.07183664142074 0.3125 22.4 22 4 abnormal kidney physiology 0.105375701296712 0.407972073113727 1.07183664142074 0.3125 22.4 22 4 thymus atrophy 0.105375701296712 0.407972073113727 1.07183664142074 0.3125 22.4 22 4 abnormal diaphragm morphology 0.166633262592511 0.534839020256608 1.07183664142074 0.3125 22.4 22 4 failure of tooth eruption 0.284486773353384 0.637819602268177 1.07183664142074 0.3125 22.4 22 4 abnormal bone marrow cell number 0.284486773353384 0.637819602268177 1.07183664142074 0.3125 22.4 22 4 delayed hair appearance 0.284486773353384 0.637819602268177 1.07183664142074 0.3125 22.4 22 4 abnormal olfaction 0.284486773353384 0.637819602268177 1.07183664142074 0.3125 22.4 22 4 abnormal epicardium morphology 0.284486773353384 0.637819602268177 1.07183664142074 0.3125 22.4 22 4 decreased cochlear coiling 0.284486773353384 0.637819602268177 1.07183664142074 0.3125 22.4 22 4 abnormal molar crown morphology 0.284486773353384 0.637819602268177 1.07183664142074 0.3125 22.4 22 4 bowed radius 0.284486773353384 0.637819602268177 1.07183664142074 0.3125 22.4 22 4 abnormal level of surface class II molecules 0.284486773353384 0.637819602268177 1.07183664142074 0.3125 22.4 22 4 dystonia 0.284486773353384 0.637819602268177 1.07183664142074 0.3125 22.4 22 4 impaired somite development 0.284486773353384 0.637819602268177 1.07183664142074 0.3125 22.4 22 4 abnormal thoracic cage shape 0.284486773353384 0.637819602268177 1.07183664142074 0.3125 22.4 22 4 decreased skeletal muscle weight 0.284486773353384 0.637819602268177 1.07183664142074 0.3125 22.4 22 4 dilated respiratory conducting tubes 0.284486773353384 0.637819602268177 1.07183664142074 0.3125 22.4 22 4 decreased adipocyte glucose uptake 0.284486773353384 0.637819602268177 1.07183664142074 0.3125 22.4 22 4 polyuria 0.0512208439223473 0.251802073630116 1.06905265014432 0.311688311688312 22.4 22 4 respiratory failure 0.00939099045211484 0.0893311233255666 1.06757768787867 0.311258278145695 22.4 22 4 irregular heartbeat 0.118542752216921 0.441914998237266 1.06707292301442 0.311111111111111 22.4 22 4 increased circulating corticosterone level 0.118542752216921 0.441914998237266 1.06707292301442 0.311111111111111 22.4 22 4 albuminuria 0.118542752216921 0.441914998237266 1.06707292301442 0.311111111111111 22.4 22 4 small placenta 0.118542752216921 0.441914998237266 1.06707292301442 0.311111111111111 22.4 22 4 lethality at weaning, complete penetrance 0.118542752216921 0.441914998237266 1.06707292301442 0.311111111111111 22.4 22 4 cochlear ganglion degeneration 0.0862343966531339 0.349361663965262 1.06444466458335 0.310344827586207 22.4 22 4 abnormal enzyme/coenzyme level 0.0862343966531339 0.349361663965262 1.06444466458335 0.310344827586207 22.4 22 4 absent long term depression 0.189690489408954 0.540190451462707 1.06444466458335 0.310344827586207 22.4 22 4 enlarged epididymis 0.189690489408954 0.540190451462707 1.06444466458335 0.310344827586207 22.4 22 4 increased double-positive T cell number 0.189690489408954 0.540190451462707 1.06444466458335 0.310344827586207 22.4 22 4 increased retinal apoptosis 0.189690489408954 0.540190451462707 1.06444466458335 0.310344827586207 22.4 22 4 increased circulating calcium level 0.0965845855838574 0.385022686922829 1.06014387805978 0.309090909090909 22.4 22 4 decreased circulating alanine transaminase level 0.0709680503880838 0.325018581112913 1.05922679858049 0.308823529411765 22.4 22 4 abnormal skeleton development 0.0527145010335852 0.253157082420652 1.05860409029209 0.308641975308642 22.4 22 4 abnormal lipid homeostasis 0.0188832632040326 0.142555742701156 1.05534684693734 0.307692307692308 22.4 22 4 increased thermal nociceptive threshold 0.0438168339178968 0.243562847755907 1.05534684693734 0.307692307692308 22.4 22 4 absent corpus luteum 0.108295289302617 0.418949505661367 1.05534684693734 0.307692307692308 22.4 22 4 abnormal xiphoid process morphology 0.216742108436065 0.540190451462707 1.05534684693734 0.307692307692308 22.4 22 4 abnormal stomach morphology 0.216742108436065 0.540190451462707 1.05534684693734 0.307692307692308 22.4 22 4 abnormal ureter morphology 0.216742108436065 0.540190451462707 1.05534684693734 0.307692307692308 22.4 22 4 increased susceptibility to otitis media 0.216742108436065 0.540190451462707 1.05534684693734 0.307692307692308 22.4 22 4 decreased neutrophil cell number 0.0248901062046631 0.171033533657733 1.05534684693734 0.307692307692308 22.4 22 4 acanthosis 0.150787388594238 0.492882561272229 1.05534684693734 0.307692307692308 22.4 22 4 abnormal pulmonary alveolus morphology 0.0365167636619991 0.217694014241488 1.0527346022667 0.306930693069307 22.4 22 4 abnormal suckling behavior 0.0486660353828628 0.251103196926389 1.05234870248581 0.306818181818182 22.4 22 4 hyperglycemia 0.0486660353828628 0.251103196926389 1.05234870248581 0.306818181818182 22.4 22 4 decreased urine osmolality 0.121572852427402 0.441914998237266 1.04996242424888 0.306122448979592 22.4 22 4 head tilt 0.170582401648954 0.539852066287244 1.04801804938916 0.305555555555556 22.4 22 4 narrow eye opening 0.170582401648954 0.539852066287244 1.04801804938916 0.305555555555556 22.4 22 4 abnormal excitatory postsynaptic potential 0.0601043167311993 0.282894016781189 1.04569428431291 0.304878048780488 22.4 22 4 abnormal lens morphology 0.0236405645841694 0.165185124727869 1.04504072538522 0.3046875 22.4 22 4 delayed wound healing 0.136662171732548 0.453262869579618 1.04387568555759 0.304347826086957 22.4 22 4 bidirectional circling 0.248782353321059 0.586028507467931 1.04387568555759 0.304347826086957 22.4 22 4 hypotension 0.248782353321059 0.586028507467931 1.04387568555759 0.304347826086957 22.4 22 4 pancreas inflammation 0.248782353321059 0.586028507467931 1.04387568555759 0.304347826086957 22.4 22 4 abnormal crista ampullaris morphology 0.248782353321059 0.586028507467931 1.04387568555759 0.304347826086957 22.4 22 4 abnormal basicranium morphology 0.248782353321059 0.586028507467931 1.04387568555759 0.304347826086957 22.4 22 4 abnormal hepatocyte physiology 0.248782353321059 0.586028507467931 1.04387568555759 0.304347826086957 22.4 22 4 abnormal neuron differentiation 0.0345513442326062 0.210138065473369 1.04121273738014 0.303571428571429 22.4 22 4 abnormal motor capabilities/coordination/movement 0.024168245948233 0.167228127388678 1.03935674319587 0.303030303030303 22.4 22 4 abnormal epidermis stratum basale morphology 0.193450859205046 0.540190451462707 1.03935674319587 0.303030303030303 22.4 22 4 abnormal T cell subpopulation ratio 0.193450859205046 0.540190451462707 1.03935674319587 0.303030303030303 22.4 22 4 decreased sensitivity to xenobiotic induced morbidity/mortality 0.193450859205046 0.540190451462707 1.03935674319587 0.303030303030303 22.4 22 4 abnormal trabecular bone morphology 0.0319099581997498 0.204014094416122 1.03760992514007 0.302521008403361 22.4 22 4 enlarged kidney 0.124063514788791 0.441914998237266 1.03543464227815 0.30188679245283 22.4 22 4 abnormal pancreatic islet morphology 0.124063514788791 0.441914998237266 1.03543464227815 0.30188679245283 22.4 22 4 decreased susceptibility to hepatic steatosis 0.100985689435628 0.395761434604275 1.03440742537112 0.301587301587302 22.4 22 4 lung inflammation 0.0246660554522524 0.169728389868542 1.0340071129 0.301470588235294 22.4 22 4 increased circulating cholesterol level 0.0122836691247177 0.103403136878969 1.03286076355089 0.301136363636364 22.4 22 4 improved glucose tolerance 0.00872577525979934 0.0849525086448174 1.0324630505114 0.301020408163265 22.4 22 4 increased bone mineral density 0.0389989598821943 0.221231271851672 1.03199846536793 0.300884955752212 22.4 22 4 decreased insulin secretion 0.0625703547013966 0.291467710336562 1.02896317576391 0.3 22.4 22 4 abnormal social investigation 0.0757681747565626 0.336296110969262 1.02896317576391 0.3 22.4 22 4 kidney inflammation 0.139132620275206 0.460842067822337 1.02896317576391 0.3 22.4 22 4 abnormal circulating protein level 0.139132620275206 0.460842067822337 1.02896317576391 0.3 22.4 22 4 decreased circulating phosphate level 0.173507654689682 0.540190451462707 1.02896317576391 0.3 22.4 22 4 gastrointestinal hemorrhage 0.220017438389346 0.540190451462707 1.02896317576391 0.3 22.4 22 4 emphysema 0.220017438389346 0.540190451462707 1.02896317576391 0.3 22.4 22 4 abnormal pain threshold 0.220017438389346 0.540190451462707 1.02896317576391 0.3 22.4 22 4 abnormal fat pad morphology 0.220017438389346 0.540190451462707 1.02896317576391 0.3 22.4 22 4 abnormal basioccipital bone morphology 0.287197936141385 0.63876622122131 1.02896317576391 0.3 22.4 22 4 small gonad 0.287197936141385 0.63876622122131 1.02896317576391 0.3 22.4 22 4 abnormal dopamine level 0.287197936141385 0.63876622122131 1.02896317576391 0.3 22.4 22 4 abnormal trachea morphology 0.287197936141385 0.63876622122131 1.02896317576391 0.3 22.4 22 4 decreased paired-pulse facilitation 0.287197936141385 0.63876622122131 1.02896317576391 0.3 22.4 22 4 spleen atrophy 0.287197936141385 0.63876622122131 1.02896317576391 0.3 22.4 22 4 abnormal male reproductive system physiology 0.287197936141385 0.63876622122131 1.02896317576391 0.3 22.4 22 4 abnormal neuron proliferation 0.287197936141385 0.63876622122131 1.02896317576391 0.3 22.4 22 4 nuclear cataracts 0.287197936141385 0.63876622122131 1.02896317576391 0.3 22.4 22 4 decreased muscle cell glucose uptake 0.287197936141385 0.63876622122131 1.02896317576391 0.3 22.4 22 4 increased sensitivity to induced morbidity/mortality 0.0127382301977153 0.105974406745207 1.02523504831549 0.298913043478261 22.4 22 4 decreased bone trabecula number 0.156220643729532 0.507972354610733 1.02166556458828 0.297872340425532 22.4 22 4 decreased exploration in new environment 0.0770107041299368 0.336296110969262 1.02079680135308 0.297619047619048 22.4 22 4 increased brown adipose tissue amount 0.196046991474214 0.540190451462707 1.01969323724351 0.297297297297297 22.4 22 4 increased trabecular bone volume 0.196046991474214 0.540190451462707 1.01969323724351 0.297297297297297 22.4 22 4 decreased circulating LDL cholesterol level 0.114515534587176 0.43522901800703 1.0182448093497 0.296875 22.4 22 4 abnormal long bone epiphyseal plate proliferative zone 0.141094070094348 0.467027943259736 1.0162599266804 0.296296296296296 22.4 22 4 cryptorchism 0.251089149264414 0.590902799238629 1.0162599266804 0.296296296296296 22.4 22 4 abnormal skeleton morphology 0.0491684402345649 0.251103196926389 1.01405066597023 0.295652173913043 22.4 22 4 abnormal NK cell physiology 0.127759698926767 0.441914998237266 1.01209492698089 0.295081967213115 22.4 22 4 increased anxiety-related response 0.0346799178012404 0.210662504348194 1.01169041262159 0.294964028776978 22.4 22 4 increased circulating alanine transaminase level 0.0948999179299694 0.378610338172893 1.01137406164828 0.294871794871795 22.4 22 4 reduced long term potentiation 0.0542736760809835 0.259125011587054 1.01058883333955 0.294642857142857 22.4 22 4 abnormal retinal photoreceptor morphology 0.222003852871987 0.540190451462707 1.00878742721952 0.294117647058824 22.4 22 4 decreased regulatory T cell number 0.222003852871987 0.540190451462707 1.00878742721952 0.294117647058824 22.4 22 4 increased susceptibility to viral infection induced morbidity/mortality 0.222003852871987 0.540190451462707 1.00878742721952 0.294117647058824 22.4 22 4 abnormal urinary bladder morphology 0.334013342517472 0.69587184782031 1.00878742721952 0.294117647058824 22.4 22 4 abnormal involuntary movement 0.334013342517472 0.69587184782031 1.00878742721952 0.294117647058824 22.4 22 4 decreased growth hormone level 0.334013342517472 0.69587184782031 1.00878742721952 0.294117647058824 22.4 22 4 coloboma 0.334013342517472 0.69587184782031 1.00878742721952 0.294117647058824 22.4 22 4 abnormal electroretinogram waveform feature 0.334013342517472 0.69587184782031 1.00878742721952 0.294117647058824 22.4 22 4 increased kidney weight 0.158018387727782 0.512812445496227 1.00878742721952 0.294117647058824 22.4 22 4 cochlear inner hair cell degeneration 0.158018387727782 0.512812445496227 1.00878742721952 0.294117647058824 22.4 22 4 abnormal thrombosis 0.158018387727782 0.512812445496227 1.00878742721952 0.294117647058824 22.4 22 4 increased insulin sensitivity 0.0351212363945399 0.212564660660385 1.00737653571292 0.293706293706294 22.4 22 4 abnormal CNS synaptic transmission 0.0722782699010088 0.328387573294538 1.00471151842267 0.292929292929293 22.4 22 4 scaly skin 0.197774396059316 0.540190451462707 1.0038665129404 0.292682926829268 22.4 22 4 abnormal malleus morphology 0.287733688795368 0.63876622122131 1.00038086532602 0.291666666666667 22.4 22 4 decreased metastatic potential 0.287733688795368 0.63876622122131 1.00038086532602 0.291666666666667 22.4 22 4 apnea 0.287733688795368 0.63876622122131 1.00038086532602 0.291666666666667 22.4 22 4 abnormal sensory capabilities/reflexes/nociception 0.287733688795368 0.63876622122131 1.00038086532602 0.291666666666667 22.4 22 4 abnormal retinal ganglion layer morphology 0.287733688795368 0.63876622122131 1.00038086532602 0.291666666666667 22.4 22 4 increased eosinophil cell number 0.143817971286468 0.475411566212744 0.995770815255394 0.290322580645161 22.4 22 4 abnormal cranial ganglia morphology 0.252039629605425 0.591259494185052 0.995770815255394 0.290322580645161 22.4 22 4 abnormal nose morphology 0.252039629605425 0.591259494185052 0.995770815255394 0.290322580645161 22.4 22 4 increased bone marrow cell number 0.223068236340919 0.540190451462707 0.992859204684472 0.289473684210526 22.4 22 4 decreased threshold for auditory brainstem response 0.223068236340919 0.540190451462707 0.992859204684472 0.289473684210526 22.4 22 4 seizures 0.0673822163590921 0.310159096596204 0.992859204684472 0.289473684210526 22.4 22 4 abnormal autopod morphology 0.198839392343791 0.540190451462707 0.990853428513392 0.288888888888889 22.4 22 4 abnormal metabolism 0.198839392343791 0.540190451462707 0.990853428513392 0.288888888888889 22.4 22 4 abnormal brain wave pattern 0.178176400602849 0.540190451462707 0.989387669003757 0.288461538461538 22.4 22 4 decreased body temperature 0.178176400602849 0.540190451462707 0.989387669003757 0.288461538461538 22.4 22 4 abnormal colon morphology 0.160310355756459 0.519572651393085 0.988269716835391 0.288135593220339 22.4 22 4 increased hemoglobin content 0.160310355756459 0.519572651393085 0.988269716835391 0.288135593220339 22.4 22 4 organ of Corti degeneration 0.199390374123422 0.540190451462707 0.979964929298959 0.285714285714286 22.4 22 4 abnormal humoral immune response 0.0900629923389974 0.360759570762087 0.979964929298959 0.285714285714286 22.4 22 4 short mandible 0.178797085104534 0.540190451462707 0.979964929298959 0.285714285714286 22.4 22 4 abnormal seminal vesicle morphology 0.178797085104534 0.540190451462707 0.979964929298959 0.285714285714286 22.4 22 4 abnormal ovulation 0.286993039102431 0.63876622122131 0.979964929298959 0.285714285714286 22.4 22 4 abnormal respiration 0.286993039102431 0.63876622122131 0.979964929298959 0.285714285714286 22.4 22 4 straub tail 0.286993039102431 0.63876622122131 0.979964929298959 0.285714285714286 22.4 22 4 enhanced coordination 0.286993039102431 0.63876622122131 0.979964929298959 0.285714285714286 22.4 22 4 thick epidermis 0.145337838527806 0.478211472669203 0.979964929298959 0.285714285714286 22.4 22 4 decreased circulating thyroxine level 0.252072640636481 0.591259494185052 0.979964929298959 0.285714285714286 22.4 22 4 decreased bone volume 0.252072640636481 0.591259494185052 0.979964929298959 0.285714285714286 22.4 22 4 alopecia 0.10893135130166 0.420755801805712 0.974807219144754 0.284210526315789 22.4 22 4 impaired righting response 0.10893135130166 0.420755801805712 0.974807219144754 0.284210526315789 22.4 22 4 increased T cell number 0.119809480331995 0.441914998237266 0.974396946746124 0.284090909090909 22.4 22 4 teratozoospermia 0.119809480331995 0.441914998237266 0.974396946746124 0.284090909090909 22.4 22 4 circling 0.132285824077785 0.441914998237266 0.968435930130736 0.282352941176471 22.4 22 4 increased vascular permeability 0.251464283669973 0.590947005790324 0.967401276359229 0.282051282051282 22.4 22 4 abnormal response to injury 0.251464283669973 0.590947005790324 0.967401276359229 0.282051282051282 22.4 22 4 decreased trabecular bone volume 0.251464283669973 0.590947005790324 0.967401276359229 0.282051282051282 22.4 22 4 atelectasis 0.161482107841368 0.522010062710075 0.966162606351086 0.28169014084507 22.4 22 4 abnormal urine homeostasis 0.120293812486083 0.441914998237266 0.964652977278663 0.28125 22.4 22 4 abnormal vertebral body morphology 0.285459512349609 0.63876622122131 0.964652977278663 0.28125 22.4 22 4 abnormal crypts of Lieberkuhn morphology 0.285459512349609 0.63876622122131 0.964652977278663 0.28125 22.4 22 4 increased circulating follicle stimulating hormone level 0.285459512349609 0.63876622122131 0.964652977278663 0.28125 22.4 22 4 decreased oocyte number 0.222823945064394 0.540190451462707 0.96036563071298 0.28 22.4 22 4 decreased respiratory quotient 0.222823945064394 0.540190451462707 0.96036563071298 0.28 22.4 22 4 decreased placenta weight 0.327947399901174 0.69587184782031 0.96036563071298 0.28 22.4 22 4 abnormal male reproductive system morphology 0.250396617123948 0.589551902598979 0.957175047222239 0.27906976744186 22.4 22 4 abnormal chondrocyte morphology 0.222014704178579 0.540190451462707 0.952743681262877 0.277777777777778 22.4 22 4 abnormal inflammatory response 0.178551816141228 0.540190451462707 0.952743681262877 0.277777777777778 22.4 22 4 abnormal digit morphology 0.178551816141228 0.540190451462707 0.952743681262877 0.277777777777778 22.4 22 4 cochlear outer hair cell degeneration 0.178551816141228 0.540190451462707 0.952743681262877 0.277777777777778 22.4 22 4 increased susceptibility to bacterial infection induced morbidity/mortality 0.178551816141228 0.540190451462707 0.952743681262877 0.277777777777778 22.4 22 4 abnormal systemic arterial blood pressure 0.283415040247068 0.637819602268177 0.952743681262877 0.277777777777778 22.4 22 4 cortical renal glomerulopathies 0.384160916529141 0.730386277106222 0.952743681262877 0.277777777777778 22.4 22 4 delayed kidney development 0.384160916529141 0.730386277106222 0.952743681262877 0.277777777777778 22.4 22 4 absent spleen 0.384160916529141 0.730386277106222 0.952743681262877 0.277777777777778 22.4 22 4 abnormal phrenic nerve morphology 0.384160916529141 0.730386277106222 0.952743681262877 0.277777777777778 22.4 22 4 thick dermal layer 0.384160916529141 0.730386277106222 0.952743681262877 0.277777777777778 22.4 22 4 acidosis 0.384160916529141 0.730386277106222 0.952743681262877 0.277777777777778 22.4 22 4 abnormal metacarpal bone morphology 0.384160916529141 0.730386277106222 0.952743681262877 0.277777777777778 22.4 22 4 decreased activity of thyroid 0.384160916529141 0.730386277106222 0.952743681262877 0.277777777777778 22.4 22 4 absent ureter 0.384160916529141 0.730386277106222 0.952743681262877 0.277777777777778 22.4 22 4 increased susceptibility to autoimmune disorder 0.384160916529141 0.730386277106222 0.952743681262877 0.277777777777778 22.4 22 4 abnormal macrophage chemotaxis 0.384160916529141 0.730386277106222 0.952743681262877 0.277777777777778 22.4 22 4 increased adipocyte glucose uptake 0.384160916529141 0.730386277106222 0.952743681262877 0.277777777777778 22.4 22 4 decreased monocyte cell number 0.198281050056699 0.540190451462707 0.949812162243606 0.276923076923077 22.4 22 4 abnormal axial skeleton morphology 0.178020864635975 0.540190451462707 0.947729240835178 0.276315789473684 22.4 22 4 glomerulosclerosis 0.220971546921282 0.540190451462707 0.946173035185202 0.275862068965517 22.4 22 4 decreased retinal photoreceptor cell number 0.324060677080899 0.694017162495684 0.946173035185202 0.275862068965517 22.4 22 4 stomach inflammation 0.324060677080899 0.694017162495684 0.946173035185202 0.275862068965517 22.4 22 4 short sternum 0.324060677080899 0.694017162495684 0.946173035185202 0.275862068965517 22.4 22 4 increased circulating insulin level 0.0830524794732169 0.337294763574901 0.943216244450248 0.275 22.4 22 4 perinatal lethality 0.281034039490083 0.634942936631772 0.943216244450248 0.275 22.4 22 4 abnormal skin pigmentation 0.281034039490083 0.634942936631772 0.943216244450248 0.275 22.4 22 4 abnormal skeleton physiology 0.319962757278821 0.68612703338885 0.935421068876279 0.272727272727273 22.4 22 4 abnormal locomotor coordination 0.319962757278821 0.68612703338885 0.935421068876279 0.272727272727273 22.4 22 4 single kidney 0.319962757278821 0.68612703338885 0.935421068876279 0.272727272727273 22.4 22 4 abnormal eye electrophysiology 0.130239370266516 0.441914998237266 0.935421068876279 0.272727272727273 22.4 22 4 abnormal photoreceptor outer segment morphology 0.278429379096918 0.629630073185075 0.935421068876279 0.272727272727273 22.4 22 4 decreased macrophage cell number 0.278429379096918 0.629630073185075 0.935421068876279 0.272727272727273 22.4 22 4 abnormal amino acid level 0.278429379096918 0.629630073185075 0.935421068876279 0.272727272727273 22.4 22 4 abnormal long bone epiphysis morphology 0.376332506770838 0.730386277106222 0.935421068876279 0.272727272727273 22.4 22 4 abnormal tail movements 0.376332506770838 0.730386277106222 0.935421068876279 0.272727272727273 22.4 22 4 abnormal lysosome physiology 0.376332506770838 0.730386277106222 0.935421068876279 0.272727272727273 22.4 22 4 abnormal retinal outer plexiform layer morphology 0.376332506770838 0.730386277106222 0.935421068876279 0.272727272727273 22.4 22 4 abnormal blood-brain barrier function 0.376332506770838 0.730386277106222 0.935421068876279 0.272727272727273 22.4 22 4 dehydration 0.216884911880514 0.540190451462707 0.930966682834011 0.271428571428571 22.4 22 4 abnormal thoracic vertebrae morphology 0.2435431529361 0.577293167096219 0.930136204080368 0.271186440677966 22.4 22 4 increased white adipose tissue amount 0.315773576829607 0.678767391081735 0.926993852039556 0.27027027027027 22.4 22 4 abnormal long bone metaphysis morphology 0.315773576829607 0.678767391081735 0.926993852039556 0.27027027027027 22.4 22 4 increased startle reflex 0.191717298163102 0.540190451462707 0.924910719787782 0.269662921348315 22.4 22 4 increased circulating glucose level 0.127138673683889 0.441914998237266 0.924364082246536 0.269503546099291 22.4 22 4 decreased IgA level 0.272828122711716 0.624629503217112 0.923428491070173 0.269230769230769 22.4 22 4 increased susceptibility to injury 0.272828122711716 0.624629503217112 0.923428491070173 0.269230769230769 22.4 22 4 small seminal vesicle 0.368917770440951 0.730386277106222 0.923428491070173 0.269230769230769 22.4 22 4 no spontaneous movement 0.368917770440951 0.730386277106222 0.923428491070173 0.269230769230769 22.4 22 4 abnormal response/metabolism to endogenous compounds 0.211949080031551 0.540190451462707 0.920210970195364 0.268292682926829 22.4 22 4 short humerus 0.311562575414697 0.678767391081735 0.920210970195364 0.268292682926829 22.4 22 4 decreased liver weight 0.237128244125587 0.563108837482002 0.917854476033532 0.267605633802817 22.4 22 4 abnormal heart tube morphology 0.361894582059646 0.730386277106222 0.914633934012362 0.266666666666667 22.4 22 4 delayed eyelid opening 0.361894582059646 0.730386277106222 0.914633934012362 0.266666666666667 22.4 22 4 abnormal tooth morphology 0.264025207659284 0.605032431186061 0.911061145207626 0.265625 22.4 22 4 abnormal long bone hypertrophic chondrocyte zone 0.303224542288948 0.672255836848269 0.909967434349033 0.26530612244898 22.4 22 4 abnormal epidermis stratum corneum morphology 0.303224542288948 0.672255836848269 0.909967434349033 0.26530612244898 22.4 22 4 decreased susceptibility to injury 0.261070976522131 0.601137997579295 0.907908684497565 0.264705882352941 22.4 22 4 abnormal bone remodeling 0.35522796286528 0.730386277106222 0.907908684497565 0.264705882352941 22.4 22 4 abnormal skin physiology 0.35522796286528 0.730386277106222 0.907908684497565 0.264705882352941 22.4 22 4 abnormal heart left ventricle morphology 0.258127340950168 0.601137997579295 0.905106497199733 0.263888888888889 22.4 22 4 abnormal reproductive system physiology 0.348882627004139 0.724109749414097 0.902599276985883 0.263157894736842 22.4 22 4 abnormal compact bone morphology 0.348882627004139 0.724109749414097 0.902599276985883 0.263157894736842 22.4 22 4 hyporesponsive to tactile stimuli 0.348882627004139 0.724109749414097 0.902599276985883 0.263157894736842 22.4 22 4 kyphoscoliosis 0.434083468562726 0.769624111225788 0.902599276985883 0.263157894736842 22.4 22 4 enlarged adrenal glands 0.434083468562726 0.769624111225788 0.902599276985883 0.263157894736842 22.4 22 4 flaky skin 0.434083468562726 0.769624111225788 0.902599276985883 0.263157894736842 22.4 22 4 abnormal stationary movement 0.434083468562726 0.769624111225788 0.902599276985883 0.263157894736842 22.4 22 4 stereotypic behavior 0.434083468562726 0.769624111225788 0.902599276985883 0.263157894736842 22.4 22 4 altered susceptibility to infection 0.434083468562726 0.769624111225788 0.902599276985883 0.263157894736842 22.4 22 4 abnormal metatarsal bone morphology 0.434083468562726 0.769624111225788 0.902599276985883 0.263157894736842 22.4 22 4 abnormal response to novelty 0.434083468562726 0.769624111225788 0.902599276985883 0.263157894736842 22.4 22 4 maternal imprinting 0.434083468562726 0.769624111225788 0.902599276985883 0.263157894736842 22.4 22 4 abnormal optic vesicle formation 0.434083468562726 0.769624111225788 0.902599276985883 0.263157894736842 22.4 22 4 osteoarthritis 0.434083468562726 0.769624111225788 0.902599276985883 0.263157894736842 22.4 22 4 abnormal photoreceptor inner segment morphology 0.434083468562726 0.769624111225788 0.902599276985883 0.263157894736842 22.4 22 4 increased left ventricle weight 0.434083468562726 0.769624111225788 0.902599276985883 0.263157894736842 22.4 22 4 abnormal sternebra morphology 0.434083468562726 0.769624111225788 0.902599276985883 0.263157894736842 22.4 22 4 abnormal cochlear inner hair cell morphology 0.434083468562726 0.769624111225788 0.902599276985883 0.263157894736842 22.4 22 4 decreased eye pigmentation 0.434083468562726 0.769624111225788 0.902599276985883 0.263157894736842 22.4 22 4 decreased liver glycogen level 0.434083468562726 0.769624111225788 0.902599276985883 0.263157894736842 22.4 22 4 deafness 0.221225207695212 0.540190451462707 0.900775844103084 0.262626262626263 22.4 22 4 abnormal long bone morphology 0.291176551917725 0.646121028452579 0.899639935094127 0.262295081967213 22.4 22 4 abnormal food intake 0.283520147540356 0.637819602268177 0.894750587620789 0.260869565217391 22.4 22 4 abnormal circulating insulin level 0.421350207988406 0.75187133599079 0.894750587620789 0.260869565217391 22.4 22 4 increased susceptibility to age related obesity 0.421350207988406 0.75187133599079 0.894750587620789 0.260869565217391 22.4 22 4 decreased epididymis weight 0.421350207988406 0.75187133599079 0.894750587620789 0.260869565217391 22.4 22 4 abnormal ulna morphology 0.421350207988406 0.75187133599079 0.894750587620789 0.260869565217391 22.4 22 4 increased susceptibility to pharmacologically induced seizures 0.241004437579388 0.572040590151457 0.893197201183947 0.260416666666667 22.4 22 4 decreased circulating alkaline phosphatase level 0.33147340077325 0.69587184782031 0.891768085662053 0.26 22.4 22 4 obese 0.27617207918825 0.628890045161619 0.890877208453599 0.25974025974026 22.4 22 4 abnormal trigeminal ganglion morphology 0.410157787852739 0.733477711922134 0.889227435845352 0.259259259259259 22.4 22 4 wrinkled skin 0.410157787852739 0.733477711922134 0.889227435845352 0.259259259259259 22.4 22 4 thin epidermis 0.410157787852739 0.733477711922134 0.889227435845352 0.259259259259259 22.4 22 4 decreased susceptibility to pharmacologically induced seizures 0.410157787852739 0.733477711922134 0.889227435845352 0.259259259259259 22.4 22 4 abnormal eyelid morphology 0.400105000304592 0.730386277106222 0.88512961356035 0.258064516129032 22.4 22 4 autoimmune response 0.400105000304592 0.730386277106222 0.88512961356035 0.258064516129032 22.4 22 4 abnormal podocyte morphology 0.400105000304592 0.730386277106222 0.88512961356035 0.258064516129032 22.4 22 4 abnormal circulating hormone level 0.382475159188334 0.730386277106222 0.879455705781117 0.256410256410256 22.4 22 4 abnormal organ of Corti morphology 0.374599312090103 0.730386277106222 0.877410459953719 0.255813953488372 22.4 22 4 abnormal intestinal mucosa morphology 0.374599312090103 0.730386277106222 0.877410459953719 0.255813953488372 22.4 22 4 abnormal axon guidance 0.374599312090103 0.730386277106222 0.877410459953719 0.255813953488372 22.4 22 4 increased respiratory quotient 0.367215805134781 0.730386277106222 0.875713341075666 0.25531914893617 22.4 22 4 decreased kidney weight 0.389396200203621 0.730386277106222 0.857469313136589 0.25 22.4 22 4 increased percent body fat/body weight 0.389396200203621 0.730386277106222 0.857469313136589 0.25 22.4 22 4 increased liver weight 0.331312218810639 0.69587184782031 0.857469313136589 0.25 22.4 22 4 abnormal gametogenesis 0.406655956421165 0.730386277106222 0.857469313136589 0.25 22.4 22 4 decreased sensitivity to induced morbidity/mortality 0.406655956421165 0.730386277106222 0.857469313136589 0.25 22.4 22 4 increased susceptibility to weight loss 0.416288865754419 0.743907006870774 0.857469313136589 0.25 22.4 22 4 abnormal epidermis stratum granulosum morphology 0.426775752459002 0.761279802252971 0.857469313136589 0.25 22.4 22 4 polydipsia 0.438320162956253 0.776582197545356 0.857469313136589 0.25 22.4 22 4 abnormal long term potentiation 0.438320162956253 0.776582197545356 0.857469313136589 0.25 22.4 22 4 abnormal circulating cholesterol level 0.451212704102842 0.794894901880893 0.857469313136589 0.25 22.4 22 4 absent corpus callosum 0.451212704102842 0.794894901880893 0.857469313136589 0.25 22.4 22 4 abnormal foregut morphology 0.465889047719419 0.816457620930157 0.857469313136589 0.25 22.4 22 4 increased stereotypic behavior 0.465889047719419 0.816457620930157 0.857469313136589 0.25 22.4 22 4 abnormal primitive streak formation 0.465889047719419 0.816457620930157 0.857469313136589 0.25 22.4 22 4 decreased skin tensile strength 0.483045312703172 0.841439226434973 0.857469313136589 0.25 22.4 22 4 abnormal incus morphology 0.483045312703172 0.841439226434973 0.857469313136589 0.25 22.4 22 4 decreased circulating VLDL cholesterol level 0.483045312703172 0.841439226434973 0.857469313136589 0.25 22.4 22 4 abnormal heart electrocardiography waveform feature 0.483045312703172 0.841439226434973 0.857469313136589 0.25 22.4 22 4 abnormal circulating amino acid level 0.409719410862108 0.733477711922134 0.842425991853491 0.245614035087719 22.4 22 4 increased susceptibility to parasitic infection 0.374686169856723 0.730386277106222 0.838414439511332 0.244444444444444 22.4 22 4 abnormal ovarian follicle morphology 0.438777497702171 0.776839164081246 0.838414439511332 0.244444444444444 22.4 22 4 cardiomyopathy 0.438777497702171 0.776839164081246 0.838414439511332 0.244444444444444 22.4 22 4 abnormal cholesterol homeostasis 0.450071540057555 0.79344646059048 0.836555427450331 0.24390243902439 22.4 22 4 abnormal humerus morphology 0.462455023197022 0.814123758105161 0.8342944668356 0.243243243243243 22.4 22 4 abnormal respiratory electron transport chain 0.462455023197022 0.814123758105161 0.8342944668356 0.243243243243243 22.4 22 4 impaired fertilization 0.411101128171519 0.7349005076009 0.832970189904115 0.242857142857143 22.4 22 4 abnormal middle ear ossicle morphology 0.476194532773031 0.830960294824914 0.831485394556693 0.242424242424242 22.4 22 4 short limbs 0.40397932245413 0.730386277106222 0.827901405787052 0.241379310344828 22.4 22 4 aphagia 0.491670167246187 0.843045648089331 0.827901405787052 0.241379310344828 22.4 22 4 increased susceptibility to induced arthritis 0.491670167246187 0.843045648089331 0.827901405787052 0.241379310344828 22.4 22 4 polyphagia 0.448090893380198 0.79191310142492 0.825711190427827 0.240740740740741 22.4 22 4 enlarged liver 0.40423813561727 0.730386277106222 0.823170540611126 0.24 22.4 22 4 abnormal eye pigmentation 0.530432692161749 0.853361412747829 0.816637441082466 0.238095238095238 22.4 22 4 abnormal associative learning 0.530432692161749 0.853361412747829 0.816637441082466 0.238095238095238 22.4 22 4 hypoalgesia 0.530432692161749 0.853361412747829 0.816637441082466 0.238095238095238 22.4 22 4 abnormal bile salt homeostasis 0.530432692161749 0.853361412747829 0.816637441082466 0.238095238095238 22.4 22 4 abnormal joint morphology 0.477319734125243 0.832631724149047 0.810698259692775 0.236363636363636 22.4 22 4 abnormal inhibitory postsynaptic currents 0.472090697204052 0.82408814687374 0.807029941775613 0.235294117647059 22.4 22 4 abnormal long bone epiphyseal plate morphology 0.4941104461529 0.845032474943513 0.800304692260817 0.233333333333333 22.4 22 4 abnormal hair cycle 0.531167084476873 0.853361412747829 0.800304692260817 0.233333333333333 22.4 22 4 disorganized myocardium 0.531167084476873 0.853361412747829 0.800304692260817 0.233333333333333 22.4 22 4 enhanced paired-pulse facilitation 0.531167084476873 0.853361412747829 0.800304692260817 0.233333333333333 22.4 22 4 abnormal fertility/fecundity 0.487392652023368 0.843045648089331 0.79873853826422 0.232876712328767 22.4 22 4 oligodactyly 0.533507685587325 0.853361412747829 0.786013537041873 0.229166666666667 22.4 22 4 abnormal phalanx morphology 0.533507685587325 0.853361412747829 0.786013537041873 0.229166666666667 22.4 22 4 impaired adaptive thermogenesis 0.549705220685438 0.874570985900241 0.783971943439167 0.228571428571429 22.4 22 4 decreased susceptibility to induced arthritis 0.534791978261139 0.853361412747829 0.782252706721099 0.228070175438596 22.4 22 4 decreased food intake 0.525979954055429 0.853361412747829 0.781491019567524 0.227848101265823 22.4 22 4 intestinal ulcer 0.575756276100253 0.898772348164028 0.779517557396899 0.227272727272727 22.4 22 4 increased activated T cell number 0.575756276100253 0.898772348164028 0.779517557396899 0.227272727272727 22.4 22 4 decreased susceptibility to viral infection induced morbidity/mortality 0.575756276100253 0.898772348164028 0.779517557396899 0.227272727272727 22.4 22 4 abnormal nervous system electrophysiology 0.538622358398061 0.857212486574009 0.775805569028343 0.226190476190476 22.4 22 4 increased food intake 0.538622358398061 0.857212486574009 0.775805569028343 0.226190476190476 22.4 22 4 absent mature ovarian follicles 0.569393525693789 0.890058367234927 0.774488411865306 0.225806451612903 22.4 22 4 decreased neuronal precursor cell number 0.569393525693789 0.890058367234927 0.774488411865306 0.225806451612903 22.4 22 4 abnormal CD8-positive, alpha beta T cell morphology 0.569393525693789 0.890058367234927 0.774488411865306 0.225806451612903 22.4 22 4 impaired ovarian folliculogenesis 0.565941387141195 0.890058367234927 0.77172238182293 0.225 22.4 22 4 increased fluid intake 0.563939707688802 0.890058367234927 0.769972444449182 0.224489795918367 22.4 22 4 abnormal type II pneumocyte morphology 0.592023770096561 0.919549877062252 0.762194945010302 0.222222222222222 22.4 22 4 syndactyly 0.590078737767641 0.916815028230486 0.755735665815299 0.220338983050847 22.4 22 4 decreased eosinophil cell number 0.601653975522568 0.934216144889132 0.750285648994516 0.21875 22.4 22 4 increased dopamine level 0.606094067260299 0.939058855378383 0.750285648994516 0.21875 22.4 22 4 fragile skeleton 0.618646850575765 0.943303288611002 0.745625489683991 0.217391304347826 22.4 22 4 blistering 0.618646850575765 0.943303288611002 0.745625489683991 0.217391304347826 22.4 22 4 abnormal epidermal layer morphology 0.612433060650748 0.943303288611002 0.745625489683991 0.217391304347826 22.4 22 4 abnormal regulatory T cell physiology 0.618646850575765 0.943303288611002 0.745625489683991 0.217391304347826 22.4 22 4 increased susceptibility to fungal infection 0.618646850575765 0.943303288611002 0.745625489683991 0.217391304347826 22.4 22 4 abnormal eye physiology 0.61662315885257 0.943303288611002 0.743140071385044 0.216666666666667 22.4 22 4 short femur 0.628359674977753 0.943303288611002 0.740541679527054 0.215909090909091 22.4 22 4 abnormal stria vascularis morphology 0.630426788094848 0.943303288611002 0.734973696974219 0.214285714285714 22.4 22 4 decreased circulating progesterone level 0.630426788094848 0.943303288611002 0.734973696974219 0.214285714285714 22.4 22 4 abnormal action potential 0.63656154448184 0.943303288611002 0.734973696974219 0.214285714285714 22.4 22 4 abnormal maternal nurturing 0.642312983460772 0.943699212524352 0.730957447263978 0.213114754098361 22.4 22 4 abnormal tibia morphology 0.640220706603076 0.943303288611002 0.729761117563055 0.212765957446809 22.4 22 4 absent vibrissae 0.641067018853025 0.943303288611002 0.727549720237106 0.212121212121212 22.4 22 4 diarrhea 0.641067018853025 0.943303288611002 0.727549720237106 0.212121212121212 22.4 22 4 head tossing 0.641067018853025 0.943303288611002 0.727549720237106 0.212121212121212 22.4 22 4 impaired swimming 0.651382582795129 0.953967721344058 0.727549720237106 0.212121212121212 22.4 22 4 abnormal femur morphology 0.674962978254121 0.987049034924824 0.716690769188791 0.208955223880597 22.4 22 4 abnormal hair shaft morphology 0.66830308055459 0.978172352385727 0.714557760947158 0.208333333333333 22.4 22 4 focal hair loss 0.666624167446673 0.976002128618952 0.709629776388901 0.206896551724138 22.4 22 4 lung hemorrhage 0.674161982601921 0.986167557613806 0.706151199053662 0.205882352941176 22.4 22 4 increased susceptibility to weight gain 0.674161982601921 0.986167557613806 0.706151199053662 0.205882352941176 22.4 22 4 increased autoantibody level 0.68141591357008 0.996192821043535 0.703564564624894 0.205128205128205 22.4 22 4 abnormal excitatory postsynaptic currents 0.710262119936203 1 0.703564564624894 0.205128205128205 22.4 22 4 altered response to myocardial infarction 0.715367350985477 1 0.685975450509271 0.2 22.4 22 4 abnormal female reproductive system morphology 0.710284545177301 1 0.685975450509271 0.2 22.4 22 4 arrested T cell differentiation 0.700488438189123 1 0.685975450509271 0.2 22.4 22 4 abnormal primitive streak morphology 0.696195448454316 1 0.685975450509271 0.2 22.4 22 4 abnormal feces composition 0.696195448454316 1 0.685975450509271 0.2 22.4 22 4 abnormal energy expenditure 0.696195448454316 1 0.685975450509271 0.2 22.4 22 4 abnormal limb bone morphology 0.734349887919536 1 0.666920576884014 0.194444444444444 22.4 22 4 short radius 0.734349887919536 1 0.666920576884014 0.194444444444444 22.4 22 4 abnormal intestine physiology 0.731951217188003 1 0.663847210170262 0.193548387096774 22.4 22 4 abnormal kidney cortex morphology 0.730620767758745 1 0.659591779335838 0.192307692307692 22.4 22 4 abnormal serotonin level 0.760995174863627 1 0.643101984852442 0.1875 22.4 22 4 abnormal digestive system physiology 0.826564032239094 1 0.617377905458344 0.18 22.4 22 4 increased circulating luteinizing hormone level 0.790749063086283 1 0.612478080811849 0.178571428571429 22.4 22 4 abnormal spleen germinal center morphology 0.790749063086283 1 0.612478080811849 0.178571428571429 22.4 22 4 abnormal cartilage development 0.827908072757621 1 0.609755956008241 0.177777777777778 22.4 22 4 head bobbing 0.830267226242378 1 0.600228519195612 0.175 22.4 22 4 abnormal pancreatic beta cell morphology 0.830267226242378 1 0.600228519195612 0.175 22.4 22 4 impaired behavioral response to xenobiotic 0.834037166567941 1 0.587978957579375 0.171428571428571 22.4 22 4 abnormal innervation 0.863000672978872 1 0.583808894050444 0.170212765957447 22.4 22 4 decreased inflammatory response 0.927506127226693 1 0.571646208757726 0.166666666666667 22.4 22 4 abnormal estrous cycle 0.839832411975617 1 0.571646208757726 0.166666666666667 22.4 22 4 abnormal reflex 0.853974622297622 1 0.571646208757726 0.166666666666667 22.4 22 4 increased insulin secretion 0.871899748697738 1 0.556196311223733 0.162162162162162 22.4 22 4 abnormal body temperature homeostasis 0.86057879558862 1 0.553206008475219 0.161290322580645 22.4 22 4 decreased susceptibility to bacterial infection induced morbidity/mortality 0.86057879558862 1 0.553206008475219 0.161290322580645 22.4 22 4 increased width of hypertrophic chondrocyte zone 0.909711740933529 1 0.504393713609758 0.147058823529412 22.4 22 4 short ulna 0.926192119812545 1 0.501933256470199 0.146341463414634 22.4 22 4 absent alveolar lamellar bodies 0.000556330319636319 0.00961021993121767 4.35191978478846 0.833333333333333 22.2 22 2 delayed limb development 0.000556330319636319 0.00961021993121767 4.35191978478846 0.833333333333333 22.2 22 2 thymus cortex atrophy 0.000556330319636319 0.00961021993121767 4.35191978478846 0.833333333333333 22.2 22 2 fusion of atlas and odontoid process 1.4661046468637e-05 0.000506518792926867 4.17784299339692 0.8 22.2 22 2 vascular smooth muscle hypoplasia 4.13966647633535e-07 2.36722307123774e-05 4.10323865422912 0.785714285714286 22.2 22 2 decreased fear-related response 7.34416055483787e-05 0.00190297910209992 4.06179179913589 0.777777777777778 22.2 22 2 decreased lung compliance 0.000358152068443186 0.00689298614428612 3.91672780630961 0.75 22.2 22 2 abnormal vascular endothelial cell development 9.80791031643216e-06 0.000359757338223468 3.91672780630961 0.75 22.2 22 2 abnormal radial glial cell morphology 4.61190622525996e-05 0.00132296883130414 3.79803908490629 0.727272727272727 22.2 22 2 pharyngeal arch hypoplasia 4.61190622525996e-05 0.00132296883130414 3.79803908490629 0.727272727272727 22.2 22 2 abnormal sinus venosus morphology 0.0016877243182422 0.0220378700347899 3.73021695839011 0.714285714285714 22.2 22 2 arteritis 0.0016877243182422 0.0220378700347899 3.73021695839011 0.714285714285714 22.2 22 2 heart right ventricle outflow tract stenosis 0.0016877243182422 0.0220378700347899 3.73021695839011 0.714285714285714 22.2 22 2 abnormal conotruncal ridge morphology 0.0016877243182422 0.0220378700347899 3.73021695839011 0.714285714285714 22.2 22 2 altered tumor pathology 0.0016877243182422 0.0220378700347899 3.73021695839011 0.714285714285714 22.2 22 2 decreased collagen level 0.0016877243182422 0.0220378700347899 3.73021695839011 0.714285714285714 22.2 22 2 abnormal respiratory mechanics 0.000210596243401109 0.00445836728051285 3.6556126192223 0.7 22.2 22 2 abnormal developmental vascular remodeling 0.000210596243401109 0.00445836728051285 3.6556126192223 0.7 22.2 22 2 increased circulating fructosamine level 0.000210596243401109 0.00445836728051285 3.6556126192223 0.7 22.2 22 2 absent common myeloid progenitor cells 2.72953405305595e-05 0.000859457716072995 3.6154410519781 0.692307692307692 22.2 22 2 abnormal vascular branching morphogenesis 6.62887999304703e-08 4.64488422048014e-06 3.56066164209965 0.681818181818182 22.2 22 2 decreased level of surface class I molecules 0.000927572994232801 0.0141121579397804 3.48153582783077 0.666666666666667 22.2 22 2 abnormal ovary physiology 0.000927572994232801 0.0141121579397804 3.48153582783077 0.666666666666667 22.2 22 2 increased neuronal precursor cell number 0.000927572994232801 0.0141121579397804 3.48153582783077 0.666666666666667 22.2 22 2 abnormal incisor color 0.000927572994232801 0.0141121579397804 3.48153582783077 0.666666666666667 22.2 22 2 abnormal sphenoid bone morphology 0.000498431310411002 0.00888779845625354 3.323284199293 0.636363636363636 22.2 22 2 pulmonary hypertension 0.000498431310411002 0.00888779845625354 3.323284199293 0.636363636363636 22.2 22 2 palatal shelf hypoplasia 0.000498431310411002 0.00888779845625354 3.323284199293 0.636363636363636 22.2 22 2 abnormal exoccipital bone morphology 0.00390367806790722 0.0408858913428177 3.26393983859134 0.625 22.2 22 2 abnormal hepatobiliary system morphology 0.00390367806790722 0.0408858913428177 3.26393983859134 0.625 22.2 22 2 increased cardiac output 0.00390367806790722 0.0408858913428177 3.26393983859134 0.625 22.2 22 2 binucleate 0.00390367806790722 0.0408858913428177 3.26393983859134 0.625 22.2 22 2 small frontal bone 0.00390367806790722 0.0408858913428177 3.26393983859134 0.625 22.2 22 2 increased aorta wall thickness 0.00390367806790722 0.0408858913428177 3.26393983859134 0.625 22.2 22 2 decreased vascular endothelial cell proliferation 0.00390367806790722 0.0408858913428177 3.26393983859134 0.625 22.2 22 2 abnormal tumor vascularization 2.65212606944321e-06 0.000120272204915524 3.23285469727142 0.619047619047619 22.2 22 2 delayed intramembranous bone ossification 0.000140231160894863 0.00320281321899631 3.13338224504769 0.6 22.2 22 2 decreased thymocyte apoptosis 0.000140231160894863 0.00320281321899631 3.13338224504769 0.6 22.2 22 2 abnormal otic capsule morphology 0.00200303812048034 0.0251644309328023 3.13338224504769 0.6 22.2 22 2 abnormal gas homeostasis 0.00200303812048034 0.0251644309328023 3.13338224504769 0.6 22.2 22 2 decreased transitional stage T2 B cell number 0.00200303812048034 0.0251644309328023 3.13338224504769 0.6 22.2 22 2 thick aortic valve cusps 0.00200303812048034 0.0251644309328023 3.13338224504769 0.6 22.2 22 2 abnormal cell differentiation 7.5539842085278e-10 7.66960641580118e-08 3.0569582878514 0.585365853658537 22.2 22 2 interstitial pneumonia 0.0010299972324115 0.0152962275559618 3.04634384935192 0.583333333333333 22.2 22 2 lymphoid hyperplasia 8.36990605999997e-07 4.4298173030319e-05 2.98417356671209 0.571428571428571 22.2 22 2 abnormal ventral body wall morphology 0.000531175319169246 0.00937091210236525 2.98417356671209 0.571428571428571 22.2 22 2 sternebra fusion 0.000531175319169246 0.00937091210236525 2.98417356671209 0.571428571428571 22.2 22 2 abnormal hematopoietic stem cell physiology 1.08304034849827e-05 0.000387634944876181 2.95173689750869 0.565217391304348 22.2 22 2 abnormal vascular development 1.26878648003959e-13 3.00581558961759e-11 2.9276551279486 0.560606060606061 22.2 22 2 enlarged liver sinusoidal spaces 1.25875551104757e-07 8.34974488994889e-06 2.91834620862285 0.558823529411765 22.2 22 2 trabecula carnea hypoplasia 1.52822318156703e-09 1.46209814005692e-07 2.90127985652564 0.555555555555556 22.2 22 2 dilated uterus 0.00762380941000025 0.0641767374192068 2.90127985652564 0.555555555555556 22.2 22 2 abnormal germ cell morphology 0.00762380941000025 0.0641767374192068 2.90127985652564 0.555555555555556 22.2 22 2 abnormal artery development 0.00762380941000025 0.0641767374192068 2.90127985652564 0.555555555555556 22.2 22 2 abnormal thymus physiology 0.00762380941000025 0.0641767374192068 2.90127985652564 0.555555555555556 22.2 22 2 liver hyperplasia 0.00762380941000025 0.0641767374192068 2.90127985652564 0.555555555555556 22.2 22 2 decreased susceptibility to atherosclerosis 0.00762380941000025 0.0641767374192068 2.90127985652564 0.555555555555556 22.2 22 2 decreased transitional stage T1 B cell number 0.00762380941000025 0.0641767374192068 2.90127985652564 0.555555555555556 22.2 22 2 adipose tissue inflammation 0.00762380941000025 0.0641767374192068 2.90127985652564 0.555555555555556 22.2 22 2 pale yolk sac 2.51358622051758e-16 7.81568215442185e-14 2.89428882072678 0.55421686746988 22.2 22 2 increased adenoma incidence 3.8589906940873e-05 0.00117782077933033 2.84852931367972 0.545454545454545 22.2 22 2 abnormal ureter development 0.00380856629256354 0.0404863617638966 2.84852931367972 0.545454545454545 22.2 22 2 abnormal aorta smooth muscle morphology 0.00380856629256354 0.0404863617638966 2.84852931367972 0.545454545454545 22.2 22 2 abnormal pulmonary alveolar sac morphology 0.00380856629256354 0.0404863617638966 2.84852931367972 0.545454545454545 22.2 22 2 abnormal liver development 2.33734921270192e-07 1.43559411520889e-05 2.83496488837648 0.542857142857143 22.2 22 2 abnormal artery morphology 2.33734921270192e-07 1.43559411520889e-05 2.83496488837648 0.542857142857143 22.2 22 2 distended pericardium 4.2573656421551e-10 4.60443349341775e-08 2.81200970709408 0.538461538461538 22.2 22 2 pulmonary edema 1.05336848553189e-05 0.000379746972139212 2.81200970709408 0.538461538461538 22.2 22 2 increased foot pad pigmentation 0.00192242982863632 0.0245863454947704 2.81200970709408 0.538461538461538 22.2 22 2 abnormal aorta wall morphology 0.000977968642911398 0.0147436181772249 2.78522866226461 0.533333333333333 22.2 22 2 abnormal dorsal-ventral axis patterning 0.000500541289356606 0.00889354612338969 2.76474903974796 0.529411764705882 22.2 22 2 abnormal cardiovascular development 6.8873001620026e-05 0.00179394336680434 2.72468021308495 0.521739130434783 22.2 22 2 liver hypoplasia 2.53685074352229e-09 2.38128914132516e-07 2.71158078898358 0.519230769230769 22.2 22 2 enlarged pericardium 2.66312333084308e-06 0.000120272204915524 2.69027768514195 0.515151515151515 22.2 22 2 increased erythroid progenitor cell number 7.33334939210067e-07 4.00916628853856e-05 2.68172354305883 0.513513513513513 22.2 22 2 abnormal embryonic hematopoiesis 8.6516173951341e-06 0.000331090742621478 2.61115187087307 0.5 22.2 22 2 ventricular hypoplasia 6.10333325755345e-05 0.00164130178142316 2.61115187087307 0.5 22.2 22 2 heart inflammation 6.10333325755345e-05 0.00164130178142316 2.61115187087307 0.5 22.2 22 2 dilated vasculature 0.000440806210746433 0.00815279003206129 2.61115187087307 0.5 22.2 22 2 vasculature congestion 0.00168120959444641 0.0220378700347899 2.61115187087307 0.5 22.2 22 2 disorganized retinal layers 0.00168120959444641 0.0220378700347899 2.61115187087307 0.5 22.2 22 2 disorganized yolk sac vascular plexus 0.00168120959444641 0.0220378700347899 2.61115187087307 0.5 22.2 22 2 abnormal pulmonary elastic fiber morphology 0.00168120959444641 0.0220378700347899 2.61115187087307 0.5 22.2 22 2 abnormal pulmonary alveolus wall morphology 0.00168120959444641 0.0220378700347899 2.61115187087307 0.5 22.2 22 2 abnormal blood flow velocity 0.00331368433810338 0.0372976913621365 2.61115187087307 0.5 22.2 22 2 split sternum 0.00331368433810338 0.0372976913621365 2.61115187087307 0.5 22.2 22 2 abnormal glucose tolerance 0.00331368433810338 0.0372976913621365 2.61115187087307 0.5 22.2 22 2 decreased compact bone area 0.00331368433810338 0.0372976913621365 2.61115187087307 0.5 22.2 22 2 abnormal renal tubule epithelial cell primary cilium morphology 0.00331368433810338 0.0372976913621365 2.61115187087307 0.5 22.2 22 2 increased osteosarcoma incidence 0.00658713535271559 0.0592603949001086 2.61115187087307 0.5 22.2 22 2 delayed somite formation 0.00658713535271559 0.0592603949001086 2.61115187087307 0.5 22.2 22 2 abnormal nucleotide metabolism 0.00658713535271559 0.0592603949001086 2.61115187087307 0.5 22.2 22 2 pale placenta 0.00658713535271559 0.0592603949001086 2.61115187087307 0.5 22.2 22 2 hematuria 0.00658713535271559 0.0592603949001086 2.61115187087307 0.5 22.2 22 2 abnormal fatty acid level 0.00658713535271559 0.0592603949001086 2.61115187087307 0.5 22.2 22 2 decreased mammary gland epithelial cell proliferation 0.00658713535271559 0.0592603949001086 2.61115187087307 0.5 22.2 22 2 abnormal colon goblet cell morphology 0.00658713535271559 0.0592603949001086 2.61115187087307 0.5 22.2 22 2 retarded hair growth 0.0132445806995201 0.101061026043118 2.61115187087307 0.5 22.2 22 2 enlarged testis 0.0132445806995201 0.101061026043118 2.61115187087307 0.5 22.2 22 2 abnormal immune cell physiology 0.0132445806995201 0.101061026043118 2.61115187087307 0.5 22.2 22 2 impaired basement membrane formation 0.0132445806995201 0.101061026043118 2.61115187087307 0.5 22.2 22 2 abnormal tibialis anterior morphology 0.0132445806995201 0.101061026043118 2.61115187087307 0.5 22.2 22 2 lymphedema 0.0132445806995201 0.101061026043118 2.61115187087307 0.5 22.2 22 2 abnormal plasma membrane morphology 0.0132445806995201 0.101061026043118 2.61115187087307 0.5 22.2 22 2 decreased macrophage cytokine production 0.0132445806995201 0.101061026043118 2.61115187087307 0.5 22.2 22 2 lethality during fetal growth through weaning, complete penetrance 0.0132445806995201 0.101061026043118 2.61115187087307 0.5 22.2 22 2 decreased circulating lactate level 0.0132445806995201 0.101061026043118 2.61115187087307 0.5 22.2 22 2 abnormal apoptosis 7.41334727103642e-09 6.35886252989762e-07 2.61115187087307 0.5 22.2 22 2 skin edema 3.44165865569327e-07 1.99095951303187e-05 2.61115187087307 0.5 22.2 22 2 abnormal basement membrane morphology 0.00022727902214261 0.00473101730192252 2.61115187087307 0.5 22.2 22 2 pulmonary vascular congestion 0.00022727902214261 0.00473101730192252 2.61115187087307 0.5 22.2 22 2 absent vitelline blood vessels 6.52060410685224e-09 5.69122902308595e-07 2.56534218892793 0.491228070175439 22.2 22 2 abnormal myocardial trabeculae morphology 3.00643357203136e-07 1.75964788480659e-05 2.55312627374256 0.488888888888889 22.2 22 2 hemopericardium 1.08432656246306e-06 5.56136561675644e-05 2.54746523987617 0.48780487804878 22.2 22 2 increased bone trabecula number 1.08432656246306e-06 5.56136561675644e-05 2.54746523987617 0.48780487804878 22.2 22 2 abnormal spinal nerve morphology 5.23175372366225e-05 0.0014540768030849 2.5211121511878 0.482758620689655 22.2 22 2 abnormal fetal cardiomyocyte proliferation 0.000100401864996547 0.0024727687047417 2.51444254232222 0.481481481481481 22.2 22 2 spontaneous skin ulceration 0.000193126115155462 0.00417740183868881 2.50670579603815 0.48 22.2 22 2 abnormal vitelline vasculature morphology 1.76121903638245e-15 5.15415570941335e-13 2.4976235286612 0.478260869565217 22.2 22 2 disheveled coat 1.75719992327555e-06 8.32578058885321e-05 2.4868113055934 0.476190476190476 22.2 22 2 vascular ring 0.000720689616387061 0.0115659059404053 2.4868113055934 0.476190476190476 22.2 22 2 abnormal blood vessel morphology 6.81578236368141e-19 3.76761302881278e-16 2.48509626331368 0.475862068965517 22.2 22 2 thin dermal layer 0.00139966012249766 0.0195050675334058 2.47372282503765 0.473684210526316 22.2 22 2 abnormal embryo turning 6.12066106032584e-08 4.35004125358872e-06 2.46872540518909 0.472727272727273 22.2 22 2 abnormal nervous system development 2.29635431066428e-05 0.000741841733477583 2.45755470199819 0.470588235294118 22.2 22 2 abnormal vagus nerve morphology 0.00273069253230401 0.0322688725610747 2.45755470199819 0.470588235294118 22.2 22 2 delayed heart development 0.00273069253230401 0.0322688725610747 2.45755470199819 0.470588235294118 22.2 22 2 kidney cortex cysts 4.37855326515063e-05 0.00128895281030322 2.44795487894351 0.46875 22.2 22 2 abnormal lymphatic vessel morphology 4.37855326515063e-05 0.00128895281030322 2.44795487894351 0.46875 22.2 22 2 abnormal heart atrium morphology 4.37855326515063e-05 0.00128895281030322 2.44795487894351 0.46875 22.2 22 2 vagina atresia 0.00535743557139636 0.0501944293176966 2.43707507948154 0.466666666666667 22.2 22 2 placental labyrinth hypoplasia 0.00535743557139636 0.0501944293176966 2.43707507948154 0.466666666666667 22.2 22 2 immune system phenotype 0.00535743557139636 0.0501944293176966 2.43707507948154 0.466666666666667 22.2 22 2 bicuspid aortic valve 0.00535743557139636 0.0501944293176966 2.43707507948154 0.466666666666667 22.2 22 2 abnormal embryonic neuroepithelium morphology 5.13906527376175e-08 3.75983084367128e-06 2.43107243150252 0.46551724137931 22.2 22 2 abnormal ureter morphology 0.000306348500223972 0.00604795154212008 2.41029403465207 0.461538461538462 22.2 22 2 abnormal renal/urinary system morphology 0.010585454373355 0.084125615826583 2.41029403465207 0.461538461538462 22.2 22 2 increased cochlear inner hair cell number 0.010585454373355 0.084125615826583 2.41029403465207 0.461538461538462 22.2 22 2 abnormal aorta tunica media morphology 0.010585454373355 0.084125615826583 2.41029403465207 0.461538461538462 22.2 22 2 absent hypoglossal nerve 0.010585454373355 0.084125615826583 2.41029403465207 0.461538461538462 22.2 22 2 abnormal angiogenesis 1.52317955531807e-09 1.46209814005692e-07 2.3994368543158 0.459459459459459 22.2 22 2 increased red blood cell distribution width 3.59982539191297e-05 0.00110550193362759 2.38733885336967 0.457142857142857 22.2 22 2 abnormal cell death 2.3013345350557e-06 0.000106010549184279 2.38409518644933 0.456521739130435 22.2 22 2 decreased circulating total protein level 2.83216734052745e-07 1.67738482370524e-05 2.37377442806643 0.454545454545455 22.2 22 2 abnormal facial nerve morphology 0.00113186511159077 0.0162746500871794 2.37377442806643 0.454545454545455 22.2 22 2 absent semicircular canals 0.0211079260386506 0.136904917331426 2.37377442806643 0.454545454545455 22.2 22 2 abnormal awl hair morphology 0.0211079260386506 0.136904917331426 2.37377442806643 0.454545454545455 22.2 22 2 delayed hepatic development 0.0211079260386506 0.136904917331426 2.37377442806643 0.454545454545455 22.2 22 2 social withdrawal 0.0211079260386506 0.136904917331426 2.37377442806643 0.454545454545455 22.2 22 2 abnormal proximal-distal axis patterning 0.0211079260386506 0.136904917331426 2.37377442806643 0.454545454545455 22.2 22 2 abnormal bronchiole morphology 0.0211079260386506 0.136904917331426 2.37377442806643 0.454545454545455 22.2 22 2 impaired luteinization 0.0211079260386506 0.136904917331426 2.37377442806643 0.454545454545455 22.2 22 2 abnormal lymph circulation 0.0211079260386506 0.136904917331426 2.37377442806643 0.454545454545455 22.2 22 2 pathological neovascularization 0.0211079260386506 0.136904917331426 2.37377442806643 0.454545454545455 22.2 22 2 abnormal coronal suture morphology 0.0211079260386506 0.136904917331426 2.37377442806643 0.454545454545455 22.2 22 2 abnormal dorsal-ventral polarity of the somites 0.0211079260386506 0.136904917331426 2.37377442806643 0.454545454545455 22.2 22 2 abnormal palatal shelf elevation 0.0211079260386506 0.136904917331426 2.37377442806643 0.454545454545455 22.2 22 2 increased number of Howell-Jolly bodies 0.0211079260386506 0.136904917331426 2.37377442806643 0.454545454545455 22.2 22 2 increased subcutaneous adipose tissue amount 0.0211079260386506 0.136904917331426 2.37377442806643 0.454545454545455 22.2 22 2 chylous ascites 0.0211079260386506 0.136904917331426 2.37377442806643 0.454545454545455 22.2 22 2 abnormal definitive hematopoiesis 3.75546055890278e-11 4.55693080013203e-09 2.35845975433697 0.451612903225806 22.2 22 2 abnormal capillary morphology 0.000129961708286511 0.00304980895625185 2.35845975433697 0.451612903225806 22.2 22 2 inner cell mass degeneration 0.000129961708286511 0.00304980895625185 2.35845975433697 0.451612903225806 22.2 22 2 abnormal vascular regression 0.00218417695938503 0.0267642373717746 2.35003668378577 0.45 22.2 22 2 abnormal erythropoiesis 3.90557010876182e-12 5.88794281548184e-10 2.3376026272578 0.447619047619048 22.2 22 2 incomplete somite formation 2.91964404042494e-05 0.000913536421453716 2.33629377920222 0.447368421052632 22.2 22 2 abnormal cell adhesion 8.11991096881041e-07 4.34371581396041e-05 2.32102388522051 0.444444444444444 22.2 22 2 abnormal pharyngeal arch morphology 5.51500169339264e-05 0.00151544852466771 2.32102388522051 0.444444444444444 22.2 22 2 renal hypoplasia 5.51500169339264e-05 0.00151544852466771 2.32102388522051 0.444444444444444 22.2 22 2 abnormal type II pneumocyte morphology 0.000471105808405912 0.00855383721466938 2.32102388522051 0.444444444444444 22.2 22 2 increased circulating renin level 0.00422836073835025 0.0423962610617859 2.32102388522051 0.444444444444444 22.2 22 2 decreased activity of thyroid 0.00422836073835025 0.0423962610617859 2.32102388522051 0.444444444444444 22.2 22 2 absent inner cell mass 0.00422836073835025 0.0423962610617859 2.32102388522051 0.444444444444444 22.2 22 2 primary atelectasis 0.00422836073835025 0.0423962610617859 2.32102388522051 0.444444444444444 22.2 22 2 kidney failure 1.24684259340176e-05 0.000436833936772801 2.30752956030644 0.441860465116279 22.2 22 2 pericardial edema 4.36066896343797e-08 3.28701940804604e-06 2.3039575331233 0.441176470588235 22.2 22 2 abnormal interventricular septum morphology 2.84644834811374e-06 0.00012422000466549 2.29781364636831 0.44 22.2 22 2 increased B cell derived lymphoma incidence 2.84644834811374e-06 0.00012422000466549 2.29781364636831 0.44 22.2 22 2 abnormal hair follicle orientation 0.00821672244235746 0.0679039769945654 2.28475788701394 0.4375 22.2 22 2 increased pancreatic beta cell number 0.00821672244235746 0.0679039769945654 2.28475788701394 0.4375 22.2 22 2 small pancreas 0.00821672244235746 0.0679039769945654 2.28475788701394 0.4375 22.2 22 2 decreased circulating triiodothyronine level 0.00821672244235746 0.0679039769945654 2.28475788701394 0.4375 22.2 22 2 small heart 5.32756748410531e-06 0.000212037185867391 2.28475788701394 0.4375 22.2 22 2 abnormal blood vessel physiology 0.00171600401207984 0.0222901304441181 2.27056684423746 0.434782608695652 22.2 22 2 abnormal postnatal growth 0.00171600401207984 0.0222901304441181 2.27056684423746 0.434782608695652 22.2 22 2 extramedullary hematopoiesis 2.46781596081523e-11 3.26169022990099e-09 2.2662827558521 0.433962264150943 22.2 22 2 ventricular septal defect 4.1088004325206e-14 1.0220641075895e-11 2.26555824090458 0.433823529411765 22.2 22 2 kidney cysts 2.8175742214153e-08 2.22498916691129e-06 2.25829350994428 0.432432432432432 22.2 22 2 lethality throughout fetal growth and development, incomplete penetrance 1.05098994609138e-17 3.73476784414614e-15 2.24646585538801 0.430167597765363 22.2 22 2 corneal vascularization 0.000704514121477869 0.0113429053538913 2.23813017503406 0.428571428571429 22.2 22 2 abnormal mitotic spindle morphology 0.000704514121477869 0.0113429053538913 2.23813017503406 0.428571428571429 22.2 22 2 absent visceral yolk sac blood islands 0.0160392818997937 0.112387925987991 2.23813017503406 0.428571428571429 22.2 22 2 amyloid beta deposits 0.0160392818997937 0.112387925987991 2.23813017503406 0.428571428571429 22.2 22 2 abnormal pancreas development 0.0160392818997937 0.112387925987991 2.23813017503406 0.428571428571429 22.2 22 2 testis degeneration 0.0160392818997937 0.112387925987991 2.23813017503406 0.428571428571429 22.2 22 2 multiple persisting craniopharyngeal ducts 0.0160392818997937 0.112387925987991 2.23813017503406 0.428571428571429 22.2 22 2 abnormal hematopoietic system physiology 0.00328179246663351 0.0372976913621365 2.23813017503406 0.428571428571429 22.2 22 2 embryonic lethality at implantation, complete penetrance 0.00328179246663351 0.0372976913621365 2.23813017503406 0.428571428571429 22.2 22 2 lethality throughout fetal growth and development, complete penetrance 2.91962309449337e-18 1.11731729962342e-15 2.22635054253388 0.426315789473684 22.2 22 2 abnormal cell cycle 1.26449638317951e-11 1.79739128751944e-09 2.22515550735271 0.426086956521739 22.2 22 2 abnormal cell morphology 3.39350099186349e-11 4.22066685863021e-09 2.1988647333668 0.421052631578947 22.2 22 2 enlarged adrenal glands 0.00628559754987941 0.057695291163561 2.1988647333668 0.421052631578947 22.2 22 2 decreased tumor incidence 0.00628559754987941 0.057695291163561 2.1988647333668 0.421052631578947 22.2 22 2 increased liver adenoma incidence 0.00628559754987941 0.057695291163561 2.1988647333668 0.421052631578947 22.2 22 2 decreased liver glycogen level 0.00628559754987941 0.057695291163561 2.1988647333668 0.421052631578947 22.2 22 2 thin interventricular septum 0.00628559754987941 0.057695291163561 2.1988647333668 0.421052631578947 22.2 22 2 decreased thymus weight 0.000547632110230914 0.00955954297683789 2.1899983433129 0.419354838709677 22.2 22 2 pale liver 1.11885580649079e-07 7.52203734769145e-06 2.18772183775852 0.418918918918919 22.2 22 2 abnormal vasculogenesis 5.09806175216612e-05 0.00143292978627268 2.18608063607978 0.418604651162791 22.2 22 2 internal hemorrhage 4.81839782038849e-07 2.66350323960364e-05 2.18245529505809 0.417910447761194 22.2 22 2 abnormal placenta morphology 4.79197425603027e-08 3.55821969011203e-06 2.18146865161548 0.417721518987342 22.2 22 2 intracranial hemorrhage 2.08402388216318e-06 9.68973720912319e-05 2.17595989239423 0.416666666666667 22.2 22 2 overriding aortic valve 2.14582095290653e-05 0.000702332844783553 2.17595989239423 0.416666666666667 22.2 22 2 vertebral transformation 2.14582095290653e-05 0.000702332844783553 2.17595989239423 0.416666666666667 22.2 22 2 abnormal retinal blood vessel morphology 0.000226958827873889 0.00473101730192252 2.17595989239423 0.416666666666667 22.2 22 2 abnormal glossopharyngeal nerve morphology 0.0314799193857471 0.166014921875734 2.17595989239423 0.416666666666667 22.2 22 2 impaired embryo implantation 0.0314799193857471 0.166014921875734 2.17595989239423 0.416666666666667 22.2 22 2 abnormal thymus involution 0.0314799193857471 0.166014921875734 2.17595989239423 0.416666666666667 22.2 22 2 myocarditis 0.0314799193857471 0.166014921875734 2.17595989239423 0.416666666666667 22.2 22 2 abnormal embryonic growth/weight/body size 0.0314799193857471 0.166014921875734 2.17595989239423 0.416666666666667 22.2 22 2 altered tumor susceptibility 0.0314799193857471 0.166014921875734 2.17595989239423 0.416666666666667 22.2 22 2 small thyroid gland 0.0314799193857471 0.166014921875734 2.17595989239423 0.416666666666667 22.2 22 2 small parietal bone 0.0314799193857471 0.166014921875734 2.17595989239423 0.416666666666667 22.2 22 2 decreased prostaglandin level 0.0314799193857471 0.166014921875734 2.17595989239423 0.416666666666667 22.2 22 2 abnormal aorta elastic tissue morphology 0.0314799193857471 0.166014921875734 2.17595989239423 0.416666666666667 22.2 22 2 decreased red blood cell distribution width 0.0314799193857471 0.166014921875734 2.17595989239423 0.416666666666667 22.2 22 2 persistent right dorsal aorta 0.0314799193857471 0.166014921875734 2.17595989239423 0.416666666666667 22.2 22 2 abnormal pulmonary valve cusp morphology 0.0314799193857471 0.166014921875734 2.17595989239423 0.416666666666667 22.2 22 2 increased type II pneumocyte number 0.0314799193857471 0.166014921875734 2.17595989239423 0.416666666666667 22.2 22 2 prenatal growth retardation 0.0314799193857471 0.166014921875734 2.17595989239423 0.416666666666667 22.2 22 2 decreased trophoblast giant cell number 0.00102725266218668 0.0152962275559618 2.16095327244668 0.413793103448276 22.2 22 2 abnormal embryonic erythropoiesis 0.00102725266218668 0.0152962275559618 2.16095327244668 0.413793103448276 22.2 22 2 failure to gastrulate 3.97040778286092e-05 0.00120443772681299 2.15703850202558 0.41304347826087 22.2 22 2 abnormal cervical vertebrae morphology 1.67193360671377e-05 0.000564783509086164 2.15036036424841 0.411764705882353 22.2 22 2 short maxilla 0.000423045085265937 0.00788258164493647 2.15036036424841 0.411764705882353 22.2 22 2 decreased osteoblast cell number 0.000423045085265937 0.00788258164493647 2.15036036424841 0.411764705882353 22.2 22 2 abnormal urinary bladder morphology 0.0120569433793949 0.0946084436290266 2.15036036424841 0.411764705882353 22.2 22 2 coloboma 0.0120569433793949 0.0946084436290266 2.15036036424841 0.411764705882353 22.2 22 2 increased hepatoma incidence 0.0120569433793949 0.0946084436290266 2.15036036424841 0.411764705882353 22.2 22 2 abnormal abdominal fat pad morphology 0.00477020371243232 0.0463654586011033 2.13639698525979 0.409090909090909 22.2 22 2 abnormal enterocyte morphology 0.00477020371243232 0.0463654586011033 2.13639698525979 0.409090909090909 22.2 22 2 abnormal germ layer development 0.00477020371243232 0.0463654586011033 2.13639698525979 0.409090909090909 22.2 22 2 increased myocardial infarction size 0.00477020371243232 0.0463654586011033 2.13639698525979 0.409090909090909 22.2 22 2 abnormal occipital bone morphology 0.00477020371243232 0.0463654586011033 2.13639698525979 0.409090909090909 22.2 22 2 increased circulating creatine kinase level 0.00477020371243232 0.0463654586011033 2.13639698525979 0.409090909090909 22.2 22 2 edema 9.63415551026749e-15 2.6627735368656e-12 2.12535617396646 0.406976744186047 22.2 22 2 increased fibroblast apoptosis 0.000787546759615186 0.0124778507295718 2.12156089508437 0.40625 22.2 22 2 malocclusion 0.000325306844872119 0.00639684408394779 2.11715016557276 0.405405405405405 22.2 22 2 abnormal myocardium layer morphology 1.79612514606475e-07 1.16048345476262e-05 2.11536354096047 0.40506329113924 22.2 22 2 abnormal cytotoxic T cell physiology 0.000135360556563129 0.00313218032047241 2.11378960975439 0.404761904761905 22.2 22 2 decreased erythrocyte cell number 4.35360485527099e-13 9.02466006457215e-11 2.09557411292998 0.401273885350318 22.2 22 2 hemorrhage 1.11071497300312e-18 4.60483915890878e-16 2.08892149669846 0.4 22.2 22 2 decreased oocyte number 4.36090868840707e-05 0.00128895281030322 2.08892149669846 0.4 22.2 22 2 albuminuria 0.000103996490485821 0.00254868246387665 2.08892149669846 0.4 22.2 22 2 increased circulating serum albumin level 0.000601493926566183 0.0102832724558995 2.08892149669846 0.4 22.2 22 2 abnormal brain vasculature morphology 0.00146376776618465 0.0202284573243574 2.08892149669846 0.4 22.2 22 2 ruffled hair 0.00360366164827425 0.039929213140678 2.08892149669846 0.4 22.2 22 2 abnormal keratinocyte physiology 0.00360366164827425 0.039929213140678 2.08892149669846 0.4 22.2 22 2 diaphragmatic hernia 0.00360366164827425 0.039929213140678 2.08892149669846 0.4 22.2 22 2 decreased placenta weight 0.00360366164827425 0.039929213140678 2.08892149669846 0.4 22.2 22 2 abnormal basioccipital bone morphology 0.00901987794354232 0.0734433596875991 2.08892149669846 0.4 22.2 22 2 abnormal physiological neovascularization 0.00901987794354232 0.0734433596875991 2.08892149669846 0.4 22.2 22 2 decreased hepatocyte number 0.0231605127853918 0.145117822553305 2.08892149669846 0.4 22.2 22 2 increased airway responsiveness 0.0231605127853918 0.145117822553305 2.08892149669846 0.4 22.2 22 2 abnormal cricoid cartilage morphology 0.0231605127853918 0.145117822553305 2.08892149669846 0.4 22.2 22 2 abnormal lymph node B cell domain morphology 0.0231605127853918 0.145117822553305 2.08892149669846 0.4 22.2 22 2 abnormal pericyte morphology 0.0231605127853918 0.145117822553305 2.08892149669846 0.4 22.2 22 2 abnormal ear development 0.0231605127853918 0.145117822553305 2.08892149669846 0.4 22.2 22 2 abnormal placenta size 0.0231605127853918 0.145117822553305 2.08892149669846 0.4 22.2 22 2 abnormal cerebral aqueduct morphology 0.0231605127853918 0.145117822553305 2.08892149669846 0.4 22.2 22 2 liver vascular congestion 0.0231605127853918 0.145117822553305 2.08892149669846 0.4 22.2 22 2 abnormal coronary vessel morphology 0.0231605127853918 0.145117822553305 2.08892149669846 0.4 22.2 22 2 embryonic lethality during organogenesis, complete penetrance 4.32884403851577e-42 2.1535999091616e-38 2.07959595430248 0.398214285714286 22.2 22 2 abnormal neural tube closure 1.95971186632168e-07 1.23412234619625e-05 2.07633763226052 0.397590361445783 22.2 22 2 small liver 4.59321161600931e-07 2.59673043064163e-05 2.07553097428373 0.397435897435897 22.2 22 2 decreased hematocrit 5.93724662506232e-12 8.68758881167207e-10 2.07461381521422 0.397260273972603 22.2 22 2 delayed endochondral bone ossification 0.000190532055167167 0.00413928809806401 2.06463171185313 0.395348837209302 22.2 22 2 abnormal aorta morphology 0.00110980765983615 0.0161441318938154 2.05727117099091 0.393939393939394 22.2 22 2 abnormal ovarian folliculogenesis 0.00110980765983615 0.0161441318938154 2.05727117099091 0.393939393939394 22.2 22 2 myeloid hyperplasia 0.00110980765983615 0.0161441318938154 2.05727117099091 0.393939393939394 22.2 22 2 rib bifurcation 0.0027150904081652 0.0322688725610747 2.05161932711456 0.392857142857143 22.2 22 2 absent corpus callosum 0.0027150904081652 0.0322688725610747 2.05161932711456 0.392857142857143 22.2 22 2 abnormal renal tubule epithelium morphology 0.0027150904081652 0.0322688725610747 2.05161932711456 0.392857142857143 22.2 22 2 abnormal heart development 2.13271598410011e-12 3.65871104168897e-10 2.04925843030545 0.392405063291139 22.2 22 2 decreased spleen weight 3.53074762809487e-06 0.000150221165064143 2.04351015981371 0.391304347826087 22.2 22 2 atrial septal defect 0.000145327327194028 0.00330138562917939 2.04351015981371 0.391304347826087 22.2 22 2 abnormal cranial nerve morphology 0.00673361780551606 0.0600353917248072 2.04351015981371 0.391304347826087 22.2 22 2 pancreas inflammation 0.00673361780551606 0.0600353917248072 2.04351015981371 0.391304347826087 22.2 22 2 abnormal mammary gland development 0.000348237403195159 0.00676750422224968 2.03797219190094 0.390243902439024 22.2 22 2 hydrops fetalis 2.70763556794748e-06 0.000120272204915524 2.03089589956795 0.388888888888889 22.2 22 2 heart right ventricle hypertrophy 0.000839834443915822 0.0130977315312891 2.03089589956795 0.388888888888889 22.2 22 2 abnormal mitral valve morphology 0.0170387686964232 0.11659955194595 2.03089589956795 0.388888888888889 22.2 22 2 abnormal thyroid cartilage morphology 0.0170387686964232 0.11659955194595 2.03089589956795 0.388888888888889 22.2 22 2 abnormal thymus medulla morphology 0.0170387686964232 0.11659955194595 2.03089589956795 0.388888888888889 22.2 22 2 abnormal glycogen homeostasis 0.0170387686964232 0.11659955194595 2.03089589956795 0.388888888888889 22.2 22 2 abnormal macrophage chemotaxis 0.0170387686964232 0.11659955194595 2.03089589956795 0.388888888888889 22.2 22 2 abnormal aerobic respiration 0.0170387686964232 0.11659955194595 2.03089589956795 0.388888888888889 22.2 22 2 pale kidney 0.0020423797594186 0.0254020982577688 2.02153693228883 0.387096774193548 22.2 22 2 decreased neuronal precursor cell number 0.0020423797594186 0.0254020982577688 2.02153693228883 0.387096774193548 22.2 22 2 preaxial polydactyly 0.0020423797594186 0.0254020982577688 2.02153693228883 0.387096774193548 22.2 22 2 embryonic lethality during organogenesis, incomplete penetrance 1.06760894793085e-16 3.54090301063732e-14 2.02080449137134 0.38695652173913 22.2 22 2 abnormal heart ventricle morphology 1.58697080215256e-06 7.74037229481272e-05 2.00857836221006 0.384615384615385 22.2 22 2 eyelids open at birth 8.41721950581202e-05 0.00214747010468794 2.00857836221006 0.384615384615385 22.2 22 2 increased vascular permeability 0.000634700793812315 0.0107769162089292 2.00857836221006 0.384615384615385 22.2 22 2 absent teeth 0.0445389600184923 0.212039546499521 2.00857836221006 0.384615384615385 22.2 22 2 pup cannibalization 0.0445389600184923 0.212039546499521 2.00857836221006 0.384615384615385 22.2 22 2 increased pituitary adenoma incidence 0.0445389600184923 0.212039546499521 2.00857836221006 0.384615384615385 22.2 22 2 abnormal pulmonary alveolus epithelial cell morphology 0.0445389600184923 0.212039546499521 2.00857836221006 0.384615384615385 22.2 22 2 abnormal coping response 0.0445389600184923 0.212039546499521 2.00857836221006 0.384615384615385 22.2 22 2 abnormal telomere length 0.0445389600184923 0.212039546499521 2.00857836221006 0.384615384615385 22.2 22 2 abnormal vestibulocochlear ganglion morphology 0.0445389600184923 0.212039546499521 2.00857836221006 0.384615384615385 22.2 22 2 small otic vesicle 0.0445389600184923 0.212039546499521 2.00857836221006 0.384615384615385 22.2 22 2 increased prostaglandin level 0.0445389600184923 0.212039546499521 2.00857836221006 0.384615384615385 22.2 22 2 increased erythrocyte cell number 2.70382994693098e-05 0.000856786878088 2.00188310100269 0.383333333333333 22.2 22 2 double outlet right ventricle 2.40205107732324e-08 1.92745227575534e-06 2.00106965805226 0.383177570093458 22.2 22 2 pallor 1.09318426910371e-12 2.01429323658925e-10 1.9993962896971 0.382857142857143 22.2 22 2 lung hemorrhage 0.00153494639647486 0.0208075158650202 1.99676319537353 0.382352941176471 22.2 22 2 overexpanded pulmonary alveoli 0.00153494639647486 0.0208075158650202 1.99676319537353 0.382352941176471 22.2 22 2 abnormal spleen red pulp morphology 0.00153494639647486 0.0208075158650202 1.99676319537353 0.382352941176471 22.2 22 2 decreased regulatory T cell number 0.00153494639647486 0.0208075158650202 1.99676319537353 0.382352941176471 22.2 22 2 increased susceptibility to viral infection induced morbidity/mortality 0.00153494639647486 0.0208075158650202 1.99676319537353 0.382352941176471 22.2 22 2 abnormal learning/memory/conditioning 6.39539825170422e-05 0.00169239927139513 1.9939705195758 0.381818181818182 22.2 22 2 glomerulosclerosis 4.85529723066378e-05 0.0013802916412887 1.98087383307613 0.379310344827586 22.2 22 2 abnormal middle ear morphology 0.00374654680848542 0.0403322400483302 1.98087383307613 0.379310344827586 22.2 22 2 abnormal circulating glucose level 0.00374654680848542 0.0403322400483302 1.98087383307613 0.379310344827586 22.2 22 2 decreased granulocyte number 0.00374654680848542 0.0403322400483302 1.98087383307613 0.379310344827586 22.2 22 2 increased mortality induced by gamma-irradiation 0.00374654680848542 0.0403322400483302 1.98087383307613 0.379310344827586 22.2 22 2 abnormal outer ear morphology 0.00374654680848542 0.0403322400483302 1.98087383307613 0.379310344827586 22.2 22 2 decreased embryo size 4.24993743109229e-31 4.22868774393683e-28 1.97748321601685 0.378661087866109 22.2 22 2 decreased width of hypertrophic chondrocyte zone 0.00115302515637721 0.0164836211292431 1.97600682120125 0.378378378378378 22.2 22 2 small placenta 0.000361631709775121 0.0069196836774278 1.97287030243743 0.377777777777778 22.2 22 2 abnormal kidney morphology 3.57544016835707e-12 5.63492847701713e-10 1.96955455402998 0.377142857142857 22.2 22 2 abnormal sternum morphology 1.18929996924203e-05 0.000419628889856674 1.96782459833913 0.376811594202899 22.2 22 2 microcephaly 1.18929996924203e-05 0.000419628889856674 1.96782459833913 0.376811594202899 22.2 22 2 abnormal neural tube morphology 2.4913412811304e-11 3.26169022990099e-09 1.96642301386738 0.376543209876543 22.2 22 2 abnormal lung development 1.25820312219217e-06 6.25956053290602e-05 1.96604376159855 0.376470588235294 22.2 22 2 failure of primitive streak formation 0.00279527955930065 0.0328759238948481 1.95836390315481 0.375 22.2 22 2 pancreatic islet hyperplasia 0.00279527955930065 0.0328759238948481 1.95836390315481 0.375 22.2 22 2 abnormal extraembryonic endoderm formation 0.0321267869912125 0.166014921875734 1.95836390315481 0.375 22.2 22 2 abnormal olfaction 0.0321267869912125 0.166014921875734 1.95836390315481 0.375 22.2 22 2 increased cochlear outer hair cell number 0.0321267869912125 0.166014921875734 1.95836390315481 0.375 22.2 22 2 dystonia 0.0321267869912125 0.166014921875734 1.95836390315481 0.375 22.2 22 2 kidney degeneration 0.0321267869912125 0.166014921875734 1.95836390315481 0.375 22.2 22 2 impaired somite development 0.0321267869912125 0.166014921875734 1.95836390315481 0.375 22.2 22 2 decreased fibroblast apoptosis 0.0321267869912125 0.166014921875734 1.95836390315481 0.375 22.2 22 2 abnormal embryo development 1.21434640576204e-09 1.20827467373323e-07 1.95836390315481 0.375 22.2 22 2 abnormal osteoclast morphology 0.000272773513374283 0.00553897236341656 1.95836390315481 0.375 22.2 22 2 decreased metastatic potential 0.00926082207678134 0.0747931653116674 1.95836390315481 0.375 22.2 22 2 curly vibrissae 0.00926082207678134 0.0747931653116674 1.95836390315481 0.375 22.2 22 2 abnormal vasodilation 0.00926082207678134 0.0747931653116674 1.95836390315481 0.375 22.2 22 2 abnormal tumor morphology 0.00926082207678134 0.0747931653116674 1.95836390315481 0.375 22.2 22 2 increased mean corpuscular hemoglobin 2.38849660123523e-07 1.44911836477381e-05 1.95177008529907 0.373737373737374 22.2 22 2 spleen hyperplasia 6.85889589806142e-06 0.000266585992912934 1.94966006358523 0.373333333333333 22.2 22 2 abnormal dendritic spine morphology 0.000205694602484053 0.0044109079627507 1.9455641390819 0.372549019607843 22.2 22 2 abnormal dermal layer morphology 0.00208653194687543 0.0256308553968032 1.93971281836285 0.371428571428571 22.2 22 2 ovary cysts 0.00208653194687543 0.0256308553968032 1.93971281836285 0.371428571428571 22.2 22 2 decreased glycogen level 0.00208653194687543 0.0256308553968032 1.93971281836285 0.371428571428571 22.2 22 2 abnormal hippocampus pyramidal cell morphology 0.00208653194687543 0.0256308553968032 1.93971281836285 0.371428571428571 22.2 22 2 short snout 1.05319145136583e-07 7.17757187745894e-06 1.93418657101709 0.37037037037037 22.2 22 2 abnormal small intestine morphology 0.000155086948522006 0.00349121071899087 1.93418657101709 0.37037037037037 22.2 22 2 abnormal trigeminal ganglion morphology 0.00684513996068377 0.0607033356584702 1.93418657101709 0.37037037037037 22.2 22 2 increased brain weight 0.00684513996068377 0.0607033356584702 1.93418657101709 0.37037037037037 22.2 22 2 abnormal bone trabecula morphology 0.00684513996068377 0.0607033356584702 1.93418657101709 0.37037037037037 22.2 22 2 respiratory distress 2.00381074133802e-11 2.76915512171018e-09 1.93195051717777 0.369942196531792 22.2 22 2 anemia 1.41039693749618e-13 3.1894203472925e-11 1.93051986661706 0.369668246445498 22.2 22 2 persistence of hyaloid vascular system 0.0015583780146711 0.0210677462581215 1.92400664169595 0.368421052631579 22.2 22 2 abnormal triglyceride level 0.0233114518652406 0.145513767916652 1.92400664169595 0.368421052631579 22.2 22 2 altered susceptibility to infection 0.0233114518652406 0.145513767916652 1.92400664169595 0.368421052631579 22.2 22 2 increased liver cholesterol level 0.0233114518652406 0.145513767916652 1.92400664169595 0.368421052631579 22.2 22 2 incomplete embryo turning 0.000116921248388789 0.00278360450599949 1.92400664169595 0.368421052631579 22.2 22 2 abnormal nervous system morphology 6.96813313383547e-06 0.000268732266207996 1.91704820899542 0.367088607594937 22.2 22 2 thin ventricular wall 1.72232451549191e-06 8.23900429285792e-05 1.91484470530692 0.366666666666667 22.2 22 2 absent mesoderm 8.81459990273579e-05 0.00220364997568395 1.91484470530692 0.366666666666667 22.2 22 2 increased metastatic potential 0.00506815572771218 0.0482104679643749 1.91484470530692 0.366666666666667 22.2 22 2 abnormal response to new environment 0.00506815572771218 0.0482104679643749 1.91484470530692 0.366666666666667 22.2 22 2 abnormal lactation 0.00506815572771218 0.0482104679643749 1.91484470530692 0.366666666666667 22.2 22 2 abnormal brain morphology 1.85296572105023e-10 2.09511465050566e-08 1.91376348300014 0.366459627329193 22.2 22 2 Leydig cell hyperplasia 0.00116462723292966 0.0165543442395002 1.91059892990713 0.365853658536585 22.2 22 2 increased tumor growth/size 0.00116462723292966 0.0165543442395002 1.91059892990713 0.365853658536585 22.2 22 2 abnormal snout morphology 0.000275662049183828 0.00557487274264041 1.90814944409955 0.365384615384615 22.2 22 2 renal interstitial fibrosis 0.000870907300556343 0.0134317428438292 1.89901954245314 0.363636363636364 22.2 22 2 decreased sensitivity to induced morbidity/mortality 0.000870907300556343 0.0134317428438292 1.89901954245314 0.363636363636364 22.2 22 2 abnormal epidermis stratum basale morphology 0.00375840635899466 0.0403322400483302 1.89901954245314 0.363636363636364 22.2 22 2 increased cardiomyocyte apoptosis 0.00375840635899466 0.0403322400483302 1.89901954245314 0.363636363636364 22.2 22 2 increased osteoblast cell number 0.00375840635899466 0.0403322400483302 1.89901954245314 0.363636363636364 22.2 22 2 intestinal inflammation 0.0169971810422862 0.11659955194595 1.89901954245314 0.363636363636364 22.2 22 2 abnormal cochlear sensory epithelium morphology 0.0169971810422862 0.11659955194595 1.89901954245314 0.363636363636364 22.2 22 2 abnormal circulating lipid level 0.0169971810422862 0.11659955194595 1.89901954245314 0.363636363636364 22.2 22 2 increased mammary gland tumor incidence 0.0169971810422862 0.11659955194595 1.89901954245314 0.363636363636364 22.2 22 2 increased bone volume 0.0169971810422862 0.11659955194595 1.89901954245314 0.363636363636364 22.2 22 2 abnormal cell nucleus morphology 0.000651664768163386 0.0109072040329969 1.88891837467414 0.361702127659574 22.2 22 2 increased respiratory quotient 0.000651664768163386 0.0109072040329969 1.88891837467414 0.361702127659574 22.2 22 2 decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 0.0124429748178166 0.0971802193385205 1.88002934702861 0.36 22.2 22 2 increased liver glycogen level 0.0124429748178166 0.0971802193385205 1.88002934702861 0.36 22.2 22 2 decreased birth body size 1.87141618573131e-07 1.19362763128375e-05 1.87819695975081 0.359649122807018 22.2 22 2 abnormal tooth morphology 8.80633464333532e-05 0.00220364997568395 1.87676540719002 0.359375 22.2 22 2 failure of heart looping 0.002075637258352 0.0256308553968032 1.87467313806272 0.358974358974359 22.2 22 2 increased leukocyte cell number 5.12905278297339e-09 4.63946138096229e-07 1.87282616945379 0.358620689655172 22.2 22 2 premature aging 0.00913961193430521 0.0742966819823013 1.86510847919505 0.357142857142857 22.2 22 2 midline facial cleft 0.0603721145288802 0.261402323569347 1.86510847919505 0.357142857142857 22.2 22 2 abnormal kidney blood vessel morphology 0.0603721145288802 0.261402323569347 1.86510847919505 0.357142857142857 22.2 22 2 extended life span 0.0603721145288802 0.261402323569347 1.86510847919505 0.357142857142857 22.2 22 2 abnormal fluid regulation 0.0603721145288802 0.261402323569347 1.86510847919505 0.357142857142857 22.2 22 2 abnormal antigen presentation 0.0603721145288802 0.261402323569347 1.86510847919505 0.357142857142857 22.2 22 2 abnormal endplate potential 0.0603721145288802 0.261402323569347 1.86510847919505 0.357142857142857 22.2 22 2 increased hemangioma incidence 0.0603721145288802 0.261402323569347 1.86510847919505 0.357142857142857 22.2 22 2 decreased vascular permeability 0.0603721145288802 0.261402323569347 1.86510847919505 0.357142857142857 22.2 22 2 intestinal obstruction 0.0603721145288802 0.261402323569347 1.86510847919505 0.357142857142857 22.2 22 2 abnormal vascular endothelial cell migration 0.0603721145288802 0.261402323569347 1.86510847919505 0.357142857142857 22.2 22 2 abnormal sagittal suture morphology 0.0603721145288802 0.261402323569347 1.86510847919505 0.357142857142857 22.2 22 2 abnormal maternal decidual layer morphology 0.0603721145288802 0.261402323569347 1.86510847919505 0.357142857142857 22.2 22 2 pulmonary alveolar hemorrhage 0.0603721145288802 0.261402323569347 1.86510847919505 0.357142857142857 22.2 22 2 abnormal vitelline vein topology 0.0603721145288802 0.261402323569347 1.86510847919505 0.357142857142857 22.2 22 2 hydronephrosis 9.22114286072259e-06 0.000347539285849204 1.86510847919505 0.357142857142857 22.2 22 2 abnormal colon morphology 0.00020545342934448 0.0044109079627507 1.85878607757066 0.355932203389831 22.2 22 2 abnormal cell migration 0.00115188693684943 0.0164836211292431 1.85681910817641 0.355555555555556 22.2 22 2 thymus hypoplasia 2.02513338671515e-08 1.65164567195211e-06 1.85429625612726 0.355072463768116 22.2 22 2 pericardial effusion 0.000154150990394751 0.0034859144418813 1.85307552126476 0.354838709677419 22.2 22 2 abnormal cranial ganglia morphology 0.00673233251027361 0.0600353917248072 1.85307552126476 0.354838709677419 22.2 22 2 decreased double-negative T cell number 0.00673233251027361 0.0600353917248072 1.85307552126476 0.354838709677419 22.2 22 2 decreased hemoglobin content 1.5334880016176e-08 1.27151713467459e-06 1.85188075948445 0.354609929078014 22.2 22 2 abnormal visceral yolk sac morphology 2.12744348021457e-05 0.000702332844783553 1.85094309834041 0.354430379746835 22.2 22 2 abnormal extraembryonic tissue morphology 1.70415703391266e-06 8.23124392593738e-05 1.84316602649864 0.352941176470588 22.2 22 2 decreased circulating alanine transaminase level 8.68961230839991e-05 0.0021944579306746 1.84316602649864 0.352941176470588 22.2 22 2 decreased mean corpuscular hemoglobin 8.68961230839991e-05 0.0021944579306746 1.84316602649864 0.352941176470588 22.2 22 2 increased kidney weight 0.000641838754501275 0.0108242298428605 1.84316602649864 0.352941176470588 22.2 22 2 abnormal endoderm development 0.00497120270218728 0.0478370085945488 1.84316602649864 0.352941176470588 22.2 22 2 impaired synaptic plasticity 0.00497120270218728 0.0478370085945488 1.84316602649864 0.352941176470588 22.2 22 2 abnormal adipose tissue morphology 0.0430739744158403 0.207849682559462 1.84316602649864 0.352941176470588 22.2 22 2 abnormal bone marrow cavity morphology 0.0430739744158403 0.207849682559462 1.84316602649864 0.352941176470588 22.2 22 2 hydroureter 0.0430739744158403 0.207849682559462 1.84316602649864 0.352941176470588 22.2 22 2 increased incidence of corneal inflammation 0.0430739744158403 0.207849682559462 1.84316602649864 0.352941176470588 22.2 22 2 hyperlipidemia 0.0430739744158403 0.207849682559462 1.84316602649864 0.352941176470588 22.2 22 2 abnormal cranial suture morphology 0.0430739744158403 0.207849682559462 1.84316602649864 0.352941176470588 22.2 22 2 decreased vasoconstriction 0.0430739744158403 0.207849682559462 1.84316602649864 0.352941176470588 22.2 22 2 abnormal ectoplacental cone morphology 0.0430739744158403 0.207849682559462 1.84316602649864 0.352941176470588 22.2 22 2 pancytopenia 0.0430739744158403 0.207849682559462 1.84316602649864 0.352941176470588 22.2 22 2 increased trabecular bone mass 0.0430739744158403 0.207849682559462 1.84316602649864 0.352941176470588 22.2 22 2 abnormal cell cytoskeleton morphology 0.0430739744158403 0.207849682559462 1.84316602649864 0.352941176470588 22.2 22 2 increased cell proliferation 0.000479735110136286 0.00864739917727545 1.83747724246624 0.351851851851852 22.2 22 2 abnormal neuronal precursor proliferation 0.000479735110136286 0.00864739917727545 1.83747724246624 0.351851851851852 22.2 22 2 small seminiferous tubules 4.90641781063271e-05 0.00138689935272146 1.83486347682973 0.351351351351351 22.2 22 2 abnormal branching of the mammary ductal tree 0.00367852475354669 0.0403322400483302 1.83486347682973 0.351351351351351 22.2 22 2 increased trabecular bone volume 0.00367852475354669 0.0403322400483302 1.83486347682973 0.351351351351351 22.2 22 2 embryonic lethality between implantation and somite formation, complete penetrance 2.43933805807785e-13 5.27639427779883e-11 1.83313519098028 0.351020408163265 22.2 22 2 increased hepatocellular carcinoma incidence 0.000358850936958815 0.00689298614428612 1.83238727780567 0.350877192982456 22.2 22 2 abnormal cell proliferation 0.0310069147461549 0.166014921875734 1.82780630961115 0.35 22.2 22 2 abnormal circulating enzyme level 0.0310069147461549 0.166014921875734 1.82780630961115 0.35 22.2 22 2 abnormal lens epithelium morphology 0.0310069147461549 0.166014921875734 1.82780630961115 0.35 22.2 22 2 abnormal induced retinal neovascularization 0.0310069147461549 0.166014921875734 1.82780630961115 0.35 22.2 22 2 abnormal sperm mitochondrial sheath morphology 0.0310069147461549 0.166014921875734 1.82780630961115 0.35 22.2 22 2 abnormal neuron proliferation 0.0310069147461549 0.166014921875734 1.82780630961115 0.35 22.2 22 2 decreased muscle cell glucose uptake 0.0310069147461549 0.166014921875734 1.82780630961115 0.35 22.2 22 2 perinatal lethality, incomplete penetrance 2.86738543383564e-12 4.7550808444441e-10 1.82549555574312 0.349557522123894 22.2 22 2 increased lymphocyte cell number 0.000113092534441518 0.00273243189181691 1.81645347538996 0.347826086956522 22.2 22 2 perimembraneous ventricular septal defect 0.000113092534441518 0.00273243189181691 1.81645347538996 0.347826086956522 22.2 22 2 abnormal pulmonary artery morphology 0.0224710814352303 0.143325166846501 1.81645347538996 0.347826086956522 22.2 22 2 abnormal circulating insulin level 0.0224710814352303 0.143325166846501 1.81645347538996 0.347826086956522 22.2 22 2 abnormal Wolffian duct morphology 0.0224710814352303 0.143325166846501 1.81645347538996 0.347826086956522 22.2 22 2 abnormal B cell morphology 0.0224710814352303 0.143325166846501 1.81645347538996 0.347826086956522 22.2 22 2 abnormal respiratory system physiology 0.00112110894600759 0.0162137122278714 1.81181966550377 0.346938775510204 22.2 22 2 abnormal pulmonary alveolus morphology 3.8065711094435e-06 0.000157814093912345 1.80970921743678 0.346534653465347 22.2 22 2 abnormal heart morphology 3.62447660833263e-12 5.63492847701713e-10 1.80859004043157 0.346320346320346 22.2 22 2 decreased kidney weight 0.000835697010257563 0.0130741906478974 1.80772052598905 0.346153846153846 22.2 22 2 abnormal nasal bone morphology 0.0163712244104168 0.113752571846123 1.80772052598905 0.346153846153846 22.2 22 2 abnormal xiphoid process morphology 0.0163712244104168 0.113752571846123 1.80772052598905 0.346153846153846 22.2 22 2 increased leukemia incidence 0.0163712244104168 0.113752571846123 1.80772052598905 0.346153846153846 22.2 22 2 decreased Peyer's patch number 0.0163712244104168 0.113752571846123 1.80772052598905 0.346153846153846 22.2 22 2 increased thymocyte apoptosis 0.0163712244104168 0.113752571846123 1.80772052598905 0.346153846153846 22.2 22 2 abnormal embryo size 1.22964350086385e-06 6.17926910787643e-05 1.80238801706283 0.345132743362832 22.2 22 2 increased spleen weight 1.22964350086385e-06 6.17926910787643e-05 1.80238801706283 0.345132743362832 22.2 22 2 thrombocytopenia 4.33303467462887e-08 3.28701940804604e-06 1.80079439370557 0.344827586206897 22.2 22 2 polydipsia 0.00879459834173569 0.0719623795232484 1.79516691122524 0.34375 22.2 22 2 abnormal spongiotrophoblast layer morphology 0.00879459834173569 0.0719623795232484 1.79516691122524 0.34375 22.2 22 2 increased fatty acid level 0.00879459834173569 0.0719623795232484 1.79516691122524 0.34375 22.2 22 2 abnormal intestinal goblet cell morphology 0.00647624831365431 0.0591180465328994 1.79050414002725 0.342857142857143 22.2 22 2 abnormal midbrain development 0.00647624831365431 0.0591180465328994 1.79050414002725 0.342857142857143 22.2 22 2 decreased bone mineralization 0.00647624831365431 0.0591180465328994 1.79050414002725 0.342857142857143 22.2 22 2 preweaning lethality, incomplete penetrance 1.15338789338986e-19 7.1726309620182e-17 1.78758563287154 0.342298288508557 22.2 22 2 abnormal frontal bone morphology 0.00478100105776201 0.0463654586011033 1.78657759586052 0.342105263157895 22.2 22 2 decreased neuron apoptosis 0.00478100105776201 0.0463654586011033 1.78657759586052 0.342105263157895 22.2 22 2 abnormal somite development 6.16316953197678e-05 0.00164848217320347 1.78483798768539 0.341772151898734 22.2 22 2 liver inflammation 8.98634220400477e-07 4.70600552262355e-05 1.78428711176327 0.341666666666667 22.2 22 2 abnormal developmental patterning 4.62706686727476e-05 0.00132296883130414 1.78322566791332 0.341463414634146 22.2 22 2 decreased blood urea nitrogen level 0.00262179751163043 0.0315059000491821 1.78033082104982 0.340909090909091 22.2 22 2 increased cellular sensitivity to gamma-irradiation 0.0019465381549892 0.0248308392847982 1.77780552910507 0.340425531914894 22.2 22 2 increased body length 0.00144730464805943 0.0200566591200437 1.77558327219369 0.34 22.2 22 2 atrioventricular septal defect 0.00107750898813585 0.0159068463382073 1.77361259153643 0.339622641509434 22.2 22 2 decreased liver weight 0.00018734872257788 0.00408798199484627 1.76528577185785 0.338028169014085 22.2 22 2 increased granulocyte number 0.000140344378239436 0.00320281321899631 1.76429180464397 0.337837837837838 22.2 22 2 increased oxygen consumption 4.44437366051349e-05 0.00129991654532321 1.76100940128649 0.337209302325581 22.2 22 2 embryonic lethality, complete penetrance 1.06408692846131e-14 2.78622761531317e-12 1.75168181933178 0.335423197492163 22.2 22 2 abnormal glucose homeostasis 5.26298866563492e-09 4.67560153777388e-07 1.75033257278305 0.335164835164835 22.2 22 2 prenatal lethality, complete penetrance 6.77804403258431e-13 1.34883076248428e-10 1.74702966900141 0.334532374100719 22.2 22 2 abnormal hepatocyte morphology 5.77031742799223e-06 0.000227835946065566 1.74076791391538 0.333333333333333 22.2 22 2 increased rib number 0.000133875836948195 0.00311230041503397 1.74076791391538 0.333333333333333 22.2 22 2 increased embryonic tissue cell apoptosis 0.000133875836948195 0.00311230041503397 1.74076791391538 0.333333333333333 22.2 22 2 abnormal heart looping 0.00613368295746699 0.0568250888517659 1.74076791391538 0.333333333333333 22.2 22 2 increased hepatocyte apoptosis 0.00613368295746699 0.0568250888517659 1.74076791391538 0.333333333333333 22.2 22 2 abnormal circulating hormone level 0.00613368295746699 0.0568250888517659 1.74076791391538 0.333333333333333 22.2 22 2 decreased circulating serum albumin level 1.80068769248238e-05 0.000601236326852338 1.74076791391538 0.333333333333333 22.2 22 2 delayed bone ossification 0.0001786672309482 0.00395053099541021 1.74076791391538 0.333333333333333 22.2 22 2 epidermal hyperplasia 0.00076456496887588 0.0121913805133253 1.74076791391538 0.333333333333333 22.2 22 2 abnormal craniofacial bone morphology 0.00102527257998716 0.0152962275559618 1.74076791391538 0.333333333333333 22.2 22 2 increased macrophage cell number 0.00102527257998716 0.0152962275559618 1.74076791391538 0.333333333333333 22.2 22 2 abnormal response to novel object 0.00185003759483853 0.02372148720186 1.74076791391538 0.333333333333333 22.2 22 2 abnormal thrombosis 0.00185003759483853 0.02372148720186 1.74076791391538 0.333333333333333 22.2 22 2 failure of chorioallantoic fusion 0.00185003759483853 0.02372148720186 1.74076791391538 0.333333333333333 22.2 22 2 thymus atrophy 0.00249008531079866 0.0301415436039497 1.74076791391538 0.333333333333333 22.2 22 2 impaired wound healing 0.00831877894185953 0.0685197437677999 1.74076791391538 0.333333333333333 22.2 22 2 abnormal trophoblast giant cell morphology 0.00831877894185953 0.0685197437677999 1.74076791391538 0.333333333333333 22.2 22 2 emphysema 0.01543302303167 0.109572697781098 1.74076791391538 0.333333333333333 22.2 22 2 abnormal fat pad morphology 0.01543302303167 0.109572697781098 1.74076791391538 0.333333333333333 22.2 22 2 abnormal foregut morphology 0.0290762111144549 0.163395625848482 1.74076791391538 0.333333333333333 22.2 22 2 abnormal startle reflex 0.0290762111144549 0.163395625848482 1.74076791391538 0.333333333333333 22.2 22 2 abnormal osteoblast morphology 0.0290762111144549 0.163395625848482 1.74076791391538 0.333333333333333 22.2 22 2 increased circulating total protein level 0.0290762111144549 0.163395625848482 1.74076791391538 0.333333333333333 22.2 22 2 abnormal truncus arteriosus septation 0.0290762111144549 0.163395625848482 1.74076791391538 0.333333333333333 22.2 22 2 abnormal megakaryocyte differentiation 0.0560915772755488 0.249058385054933 1.74076791391538 0.333333333333333 22.2 22 2 underdeveloped hair follicles 0.0560915772755488 0.249058385054933 1.74076791391538 0.333333333333333 22.2 22 2 cortical renal glomerulopathies 0.0560915772755488 0.249058385054933 1.74076791391538 0.333333333333333 22.2 22 2 abnormal mammary gland morphology 0.0560915772755488 0.249058385054933 1.74076791391538 0.333333333333333 22.2 22 2 eye inflammation 0.0560915772755488 0.249058385054933 1.74076791391538 0.333333333333333 22.2 22 2 abnormal thymus cortex morphology 0.0560915772755488 0.249058385054933 1.74076791391538 0.333333333333333 22.2 22 2 abnormal bile duct morphology 0.0560915772755488 0.249058385054933 1.74076791391538 0.333333333333333 22.2 22 2 abnormal metacarpal bone morphology 0.0560915772755488 0.249058385054933 1.74076791391538 0.333333333333333 22.2 22 2 abnormal body wall morphology 0.0560915772755488 0.249058385054933 1.74076791391538 0.333333333333333 22.2 22 2 increased circulating glycerol level 0.0560915772755488 0.249058385054933 1.74076791391538 0.333333333333333 22.2 22 2 darkened coat color 0.0560915772755488 0.249058385054933 1.74076791391538 0.333333333333333 22.2 22 2 decreased lactate dehydrogenase level 0.0560915772755488 0.249058385054933 1.74076791391538 0.333333333333333 22.2 22 2 abnormal pregnancy 0.0560915772755488 0.249058385054933 1.74076791391538 0.333333333333333 22.2 22 2 decreased tumor latency 0.0560915772755488 0.249058385054933 1.74076791391538 0.333333333333333 22.2 22 2 abnormal hypoglossal nerve topology 0.0560915772755488 0.249058385054933 1.74076791391538 0.333333333333333 22.2 22 2 abnormal fontanelle morphology 0.0789779154006245 0.303878676812148 1.74076791391538 0.333333333333333 22.2 22 2 absent incisors 0.0789779154006245 0.303878676812148 1.74076791391538 0.333333333333333 22.2 22 2 macrocytosis 0.0789779154006245 0.303878676812148 1.74076791391538 0.333333333333333 22.2 22 2 abnormal enteric neuron morphology 0.0789779154006245 0.303878676812148 1.74076791391538 0.333333333333333 22.2 22 2 abnormal respiratory system morphology 0.0789779154006245 0.303878676812148 1.74076791391538 0.333333333333333 22.2 22 2 dilated ureter 0.0789779154006245 0.303878676812148 1.74076791391538 0.333333333333333 22.2 22 2 abnormal trophectoderm morphology 0.0789779154006245 0.303878676812148 1.74076791391538 0.333333333333333 22.2 22 2 abnormal olfactory nerve morphology 0.0789779154006245 0.303878676812148 1.74076791391538 0.333333333333333 22.2 22 2 abnormal energy homeostasis 0.0789779154006245 0.303878676812148 1.74076791391538 0.333333333333333 22.2 22 2 ostium primum atrial septal defect 0.0789779154006245 0.303878676812148 1.74076791391538 0.333333333333333 22.2 22 2 herniated liver 0.0789779154006245 0.303878676812148 1.74076791391538 0.333333333333333 22.2 22 2 abnormal branching involved in lung morphogenesis 0.0789779154006245 0.303878676812148 1.74076791391538 0.333333333333333 22.2 22 2 decreased brown adipose tissue mass 0.0789779154006245 0.303878676812148 1.74076791391538 0.333333333333333 22.2 22 2 decreased tumor growth/size 0.00137639592713564 0.0192889288380276 1.74076791391538 0.333333333333333 22.2 22 2 decreased platelet aggregation 0.00137639592713564 0.0192889288380276 1.74076791391538 0.333333333333333 22.2 22 2 abnormal tooth development 0.0113126943331062 0.0894763979446793 1.74076791391538 0.333333333333333 22.2 22 2 belly spot 0.0113126943331062 0.0894763979446793 1.74076791391538 0.333333333333333 22.2 22 2 abnormal heart valve morphology 0.0211342666352834 0.136904917331426 1.74076791391538 0.333333333333333 22.2 22 2 thin epidermis 0.0211342666352834 0.136904917331426 1.74076791391538 0.333333333333333 22.2 22 2 decreased circulating fructosamine level 0.0211342666352834 0.136904917331426 1.74076791391538 0.333333333333333 22.2 22 2 abnormal scapula morphology 0.0402348683853353 0.201782732073632 1.74076791391538 0.333333333333333 22.2 22 2 abnormal associative learning 0.0402348683853353 0.201782732073632 1.74076791391538 0.333333333333333 22.2 22 2 liver degeneration 0.0402348683853353 0.201782732073632 1.74076791391538 0.333333333333333 22.2 22 2 abnormal erythrocyte physiology 0.0402348683853353 0.201782732073632 1.74076791391538 0.333333333333333 22.2 22 2 preweaning lethality, complete penetrance 2.37192812956425e-31 2.95008561114553e-28 1.73606313576967 0.332432432432432 22.2 22 2 embryonic growth arrest 1.25951728845853e-10 1.45723221164679e-08 1.7331663073044 0.331877729257642 22.2 22 2 enlarged spleen 9.8176682678123e-13 1.87857306278332e-10 1.7226349148121 0.329861111111111 22.2 22 2 cleft secondary palate 4.02940393271882e-05 0.00121492633728946 1.72224910632054 0.329787234042553 22.2 22 2 decreased cell proliferation 1.06012853350816e-08 8.93921941390351e-07 1.72194880133251 0.32972972972973 22.2 22 2 abnormal response to infection 0.000169316359256479 0.003777349270408 1.71873287703038 0.329113924050633 22.2 22 2 decreased bone marrow cell number 0.000301822968257121 0.00599529766195496 1.71692177810832 0.328767123287671 22.2 22 2 seminiferous tubule degeneration 0.000301822968257121 0.00599529766195496 1.71692177810832 0.328767123287671 22.2 22 2 domed cranium 0.000403385578161564 0.00757299340133502 1.71589980085945 0.328571428571429 22.2 22 2 embryonic lethality between somite formation and embryo turning, complete penetrance 0.000403385578161564 0.00757299340133502 1.71589980085945 0.328571428571429 22.2 22 2 rib fusion 0.000539533478611937 0.00948473164697663 1.71478630325993 0.328358208955224 22.2 22 2 increased double-negative T cell number 0.000967683564862302 0.0146360606798177 1.71223073499874 0.327868852459016 22.2 22 2 abnormal contextual conditioning behavior 0.0017426245483818 0.0225183302031155 1.70911758820783 0.327272727272727 22.2 22 2 increased susceptibility to injury 0.00234271730734926 0.0285662220687808 1.70729160787855 0.326923076923077 22.2 22 2 absent kidney 0.00315383142706095 0.0361527911281757 1.70524203812119 0.326530612244898 22.2 22 2 increased sarcoma incidence 0.00315383142706095 0.0361527911281757 1.70524203812119 0.326530612244898 22.2 22 2 decreased circulating creatinine level 0.00315383142706095 0.0361527911281757 1.70524203812119 0.326530612244898 22.2 22 2 abnormal immune system morphology 0.00425240889845852 0.0423962610617859 1.70292513317809 0.326086956521739 22.2 22 2 abnormal allantois morphology 0.00425240889845852 0.0423962610617859 1.70292513317809 0.326086956521739 22.2 22 2 abnormal myelin sheath morphology 0.00425240889845852 0.0423962610617859 1.70292513317809 0.326086956521739 22.2 22 2 embryonic lethality between implantation and placentation, complete penetrance 0.00425240889845852 0.0423962610617859 1.70292513317809 0.326086956521739 22.2 22 2 decreased rib number 8.98491627768542e-05 0.00223499792407425 1.7016495338274 0.325842696629214 22.2 22 2 increased white adipose tissue amount 0.0105461009522497 0.084125615826583 1.69372013245821 0.324324324324324 22.2 22 2 enlarged heart 6.46029173552301e-10 6.69582320504728e-08 1.68824474409897 0.323275862068966 22.2 22 2 abnormal object recognition memory 0.0195762089942397 0.130902741594546 1.68461411024069 0.32258064516129 22.2 22 2 prenatal lethality, incomplete penetrance 2.02851811020369e-12 3.60424199937978e-10 1.68350581148396 0.322368421052632 22.2 22 2 small superior cervical ganglion 0.026815945177852 0.154008507457936 1.67859763127555 0.321428571428571 22.2 22 2 abnormal ovulation 0.026815945177852 0.154008507457936 1.67859763127555 0.321428571428571 22.2 22 2 failure of blastocyst to hatch from the zona pellucida 0.026815945177852 0.154008507457936 1.67859763127555 0.321428571428571 22.2 22 2 abnormal brainstem morphology 0.026815945177852 0.154008507457936 1.67859763127555 0.321428571428571 22.2 22 2 increased triglyceride level 0.026815945177852 0.154008507457936 1.67859763127555 0.321428571428571 22.2 22 2 abnormal vertebrae morphology 2.53037172573991e-05 0.000812167699068133 1.67688652257904 0.321100917431193 22.2 22 2 abnormal craniofacial morphology 4.4680548593019e-05 0.00129991654532321 1.67316527648178 0.320388349514563 22.2 22 2 decreased heart rate 5.9400320528395e-05 0.00161484477939216 1.67113719735877 0.32 22.2 22 2 short stride length 0.00395690285247344 0.0413562850652424 1.67113719735877 0.32 22.2 22 2 abnormal egg cylinder morphology 0.0369036164305198 0.187342338512078 1.67113719735877 0.32 22.2 22 2 abnormal vertebrae development 0.0369036164305198 0.187342338512078 1.67113719735877 0.32 22.2 22 2 abnormal embryonic tissue morphology 1.31840249300005e-06 6.49411128977747e-05 1.669716162327 0.319727891156463 22.2 22 2 pulmonary hypoplasia 0.00533328580945977 0.0501944293176966 1.666692683536 0.319148936170213 22.2 22 2 small kidney 0.000186232343688433 0.00408152383193813 1.6616420996465 0.318181818181818 22.2 22 2 omphalocele 0.00720073924329468 0.0631810894804075 1.6616420996465 0.318181818181818 22.2 22 2 lethality, incomplete penetrance 0.00720073924329468 0.0631810894804075 1.6616420996465 0.318181818181818 22.2 22 2 embryonic lethality, incomplete penetrance 0.00720073924329468 0.0631810894804075 1.6616420996465 0.318181818181818 22.2 22 2 abnormal long bone epiphysis morphology 0.0510791224787584 0.237494050777405 1.6616420996465 0.318181818181818 22.2 22 2 abnormal chorion morphology 0.0510791224787584 0.237494050777405 1.6616420996465 0.318181818181818 22.2 22 2 increased coping response 0.0510791224787584 0.237494050777405 1.6616420996465 0.318181818181818 22.2 22 2 abnormal retinal layer morphology 0.0510791224787584 0.237494050777405 1.6616420996465 0.318181818181818 22.2 22 2 abnormal blood-brain barrier function 0.0510791224787584 0.237494050777405 1.6616420996465 0.318181818181818 22.2 22 2 rough coat 0.0510791224787584 0.237494050777405 1.6616420996465 0.318181818181818 22.2 22 2 embryonic lethality before implantation, incomplete penetrance 0.0510791224787584 0.237494050777405 1.6616420996465 0.318181818181818 22.2 22 2 skin lesions 0.00151520343195372 0.0208075158650202 1.65787420372894 0.317460317460317 22.2 22 2 decreased cardiac muscle contractility 5.5439523917492e-05 0.00151544852466771 1.6570771488233 0.317307692307692 22.2 22 2 abnormal response/metabolism to endogenous compounds 0.000330604030033923 0.00647541358038885 1.65585240591951 0.317073170731707 22.2 22 2 decreased B cell proliferation 0.000440824224849143 0.00815279003206129 1.65262776637536 0.316455696202532 22.2 22 2 abnormal cardiovascular system physiology 6.65532553679195e-06 0.000260710586972756 1.6491485500251 0.315789473684211 22.2 22 2 increased bone marrow cell number 0.0132069162881671 0.101061026043118 1.6491485500251 0.315789473684211 22.2 22 2 decreased hair follicle number 0.0132069162881671 0.101061026043118 1.6491485500251 0.315789473684211 22.2 22 2 impaired branching involved in ureteric bud morphogenesis 0.0132069162881671 0.101061026043118 1.6491485500251 0.315789473684211 22.2 22 2 small superior vagus ganglion 0.0712208659264603 0.280544357712721 1.6491485500251 0.315789473684211 22.2 22 2 short vibrissae 0.0712208659264603 0.280544357712721 1.6491485500251 0.315789473684211 22.2 22 2 abnormal long term depression 0.0712208659264603 0.280544357712721 1.6491485500251 0.315789473684211 22.2 22 2 increased malignant tumor incidence 0.0712208659264603 0.280544357712721 1.6491485500251 0.315789473684211 22.2 22 2 decreased germ cell number 0.0712208659264603 0.280544357712721 1.6491485500251 0.315789473684211 22.2 22 2 increased susceptibility to ischemic brain injury 0.0712208659264603 0.280544357712721 1.6491485500251 0.315789473684211 22.2 22 2 abnormal response to novelty 0.0712208659264603 0.280544357712721 1.6491485500251 0.315789473684211 22.2 22 2 abnormal sternebra morphology 0.0712208659264603 0.280544357712721 1.6491485500251 0.315789473684211 22.2 22 2 increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 0.0712208659264603 0.280544357712721 1.6491485500251 0.315789473684211 22.2 22 2 shortened RR interval 0.0712208659264603 0.280544357712721 1.6491485500251 0.315789473684211 22.2 22 2 abnormal facial morphology 0.00272412796799755 0.0322688725610747 1.6491485500251 0.315789473684211 22.2 22 2 neonatal lethality, incomplete penetrance 4.0974814453137e-10 4.52999337565237e-08 1.64703425701225 0.315384615384615 22.2 22 2 increased circulating alkaline phosphatase level 8.10891556049048e-07 4.34371581396041e-05 1.64405858536453 0.314814814814815 22.2 22 2 abnormal axon morphology 5.15851685276714e-05 0.00144177647991666 1.64405858536453 0.314814814814815 22.2 22 2 diluted coat color 0.00365867070204043 0.0403322400483302 1.64405858536453 0.314814814814815 22.2 22 2 abnormal osteoblast physiology 0.00365867070204043 0.0403322400483302 1.64405858536453 0.314814814814815 22.2 22 2 increased insulin sensitivity 3.53283945979995e-06 0.000150221165064143 1.64338229635368 0.314685314685315 22.2 22 2 increased tumor incidence 1.54871128042109e-05 0.00052772867260924 1.64249875748468 0.314516129032258 22.2 22 2 spleen hypoplasia 6.84901631069091e-05 0.00179336084977301 1.64129546169165 0.314285714285714 22.2 22 2 thick pulmonary interalveolar septum 0.0179523594070648 0.120621284178171 1.64129546169165 0.314285714285714 22.2 22 2 increased carcinoma incidence 0.0179523594070648 0.120621284178171 1.64129546169165 0.314285714285714 22.2 22 2 decreased circulating thyroxine level 0.0179523594070648 0.120621284178171 1.64129546169165 0.314285714285714 22.2 22 2 decreased bone volume 0.0179523594070648 0.120621284178171 1.64129546169165 0.314285714285714 22.2 22 2 impaired hematopoiesis 0.00492004125596373 0.0475285538804263 1.63836980133212 0.313725490196078 22.2 22 2 small lung 0.00492004125596373 0.0475285538804263 1.63836980133212 0.313725490196078 22.2 22 2 abnormal retinal pigment epithelium morphology 0.000544447836829052 0.00953742249374835 1.63196991929567 0.3125 22.2 22 2 abnormal diaphragm morphology 0.0244769411090143 0.151647300146134 1.63196991929567 0.3125 22.2 22 2 abnormal depression-related behavior 0.0244769411090143 0.151647300146134 1.63196991929567 0.3125 22.2 22 2 decreased mast cell number 0.100273882859448 0.359411071488296 1.63196991929567 0.3125 22.2 22 2 poor circulation 0.100273882859448 0.359411071488296 1.63196991929567 0.3125 22.2 22 2 intraventricular hemorrhage 0.100273882859448 0.359411071488296 1.63196991929567 0.3125 22.2 22 2 increased intestinal adenocarcinoma incidence 0.100273882859448 0.359411071488296 1.63196991929567 0.3125 22.2 22 2 decreased cochlear coiling 0.100273882859448 0.359411071488296 1.63196991929567 0.3125 22.2 22 2 large intestinal inflammation 0.100273882859448 0.359411071488296 1.63196991929567 0.3125 22.2 22 2 bowed tibia 0.100273882859448 0.359411071488296 1.63196991929567 0.3125 22.2 22 2 abnormal epididymis epithelium morphology 0.100273882859448 0.359411071488296 1.63196991929567 0.3125 22.2 22 2 increased thymus weight 0.100273882859448 0.359411071488296 1.63196991929567 0.3125 22.2 22 2 abnormal amnion morphology 0.100273882859448 0.359411071488296 1.63196991929567 0.3125 22.2 22 2 abnormal level of surface class II molecules 0.100273882859448 0.359411071488296 1.63196991929567 0.3125 22.2 22 2 abnormal intestinal lipid absorption 0.100273882859448 0.359411071488296 1.63196991929567 0.3125 22.2 22 2 abnormal cardiovascular system morphology 0.00662564967248753 0.0594992908314539 1.63196991929567 0.3125 22.2 22 2 increased bone mineral content 6.34994264368624e-05 0.0016893563985208 1.62897547907678 0.311926605504587 22.2 22 2 hypoglycemia 0.000213432369167765 0.00449926286698997 1.628460306566 0.311827956989247 22.2 22 2 abnormal rib morphology 1.00674487057261e-05 0.000365588009569249 1.62471671965436 0.311111111111111 22.2 22 2 abnormal lung morphology 3.34365315758066e-05 0.00103320959372446 1.62374149953452 0.310924369747899 22.2 22 2 decreased T cell proliferation 4.02852041358214e-06 0.000164277779160419 1.62314846027245 0.310810810810811 22.2 22 2 abnormal retinal pigmentation 0.000377506320774897 0.00716829750326379 1.62071495433501 0.310344827586207 22.2 22 2 absent long term depression 0.0334929902392275 0.171781058185729 1.62071495433501 0.310344827586207 22.2 22 2 abnormal CD8-positive, alpha-beta T cell physiology 0.0334929902392275 0.171781058185729 1.62071495433501 0.310344827586207 22.2 22 2 polychromatophilia 0.0334929902392275 0.171781058185729 1.62071495433501 0.310344827586207 22.2 22 2 blood in lymph vessels 0.0334929902392275 0.171781058185729 1.62071495433501 0.310344827586207 22.2 22 2 perinatal lethality, complete penetrance 4.25201206339767e-08 3.28701940804604e-06 1.61817862420303 0.309859154929577 22.2 22 2 abnormal skeletal muscle fiber morphology 0.00129207031314814 0.0182615051361136 1.61817862420303 0.309859154929577 22.2 22 2 abnormal muscle morphology 0.0120756505938557 0.0946084436290266 1.61642734863571 0.30952380952381 22.2 22 2 spina bifida 0.0120756505938557 0.0946084436290266 1.61642734863571 0.30952380952381 22.2 22 2 decreased circulating calcium level 0.00451584924446667 0.0446647117121703 1.61416661108517 0.309090909090909 22.2 22 2 abnormal head morphology 0.00451584924446667 0.0446647117121703 1.61416661108517 0.309090909090909 22.2 22 2 abnormal rostral-caudal axis patterning 0.00451584924446667 0.0446647117121703 1.61416661108517 0.309090909090909 22.2 22 2 increased neuron apoptosis 0.0006687438581383 0.0109081989975018 1.61182214251424 0.308641975308642 22.2 22 2 decreased circulating glucose level 5.59637192438881e-10 5.92381921783709e-08 1.60974237200777 0.308243727598566 22.2 22 2 postnatal lethality, incomplete penetrance 9.07379510658229e-19 4.1038300595679e-16 1.60898442747461 0.308098591549296 22.2 22 2 increased grip strength 0.000347769684701446 0.00676750422224968 1.60686268976805 0.307692307692308 22.2 22 2 abnormal placenta vasculature 0.00606551856645902 0.0565092787792764 1.60686268976805 0.307692307692308 22.2 22 2 decreased body temperature 0.00606551856645902 0.0565092787792764 1.60686268976805 0.307692307692308 22.2 22 2 abnormal kidney cortex morphology 0.0460291239950102 0.218506576216771 1.60686268976805 0.307692307692308 22.2 22 2 abnormal Mullerian duct morphology 0.0460291239950102 0.218506576216771 1.60686268976805 0.307692307692308 22.2 22 2 abnormal nerve conduction 0.0460291239950102 0.218506576216771 1.60686268976805 0.307692307692308 22.2 22 2 polydactyly 0.000240838993195525 0.00495113219482537 1.59866441073862 0.306122448979592 22.2 22 2 cardiac hypertrophy 0.000240838993195525 0.00495113219482537 1.59866441073862 0.306122448979592 22.2 22 2 abnormal long bone hypertrophic chondrocyte zone 0.00815733419252869 0.0679039769945654 1.59866441073862 0.306122448979592 22.2 22 2 increased fluid intake 0.00815733419252869 0.0679039769945654 1.59866441073862 0.306122448979592 22.2 22 2 abnormal uterus morphology 0.0221911348117551 0.142452768630299 1.5957039210891 0.305555555555556 22.2 22 2 decreased total body fat amount 2.6944990815439e-11 3.43721357196946e-09 1.59483527442547 0.305389221556886 22.2 22 2 cleft palate 2.62580616583886e-05 0.000837396517631304 1.59459656236524 0.305343511450382 22.2 22 2 increased B cell proliferation 0.0041282093262592 0.0421252779851011 1.59324520934628 0.305084745762712 22.2 22 2 decreased bone mineral density 3.27067525503015e-09 3.01326099884722e-07 1.5902503875242 0.304511278195489 22.2 22 2 decreased T cell number 3.8618354166078e-06 0.00015878207601342 1.58939679096622 0.304347826086957 22.2 22 2 conjunctivitis 0.0635951404353019 0.270415233902245 1.58939679096622 0.304347826086957 22.2 22 2 abnormal basicranium morphology 0.0635951404353019 0.270415233902245 1.58939679096622 0.304347826086957 22.2 22 2 premature death 1.3837966370134e-26 1.14739804485694e-23 1.58913307820847 0.304297328687573 22.2 22 2 abnormal placenta labyrinth morphology 0.00108694455415277 0.0159986661447042 1.58652265572035 0.30379746835443 22.2 22 2 increased neutrophil cell number 1.27243210158903e-05 0.000442681797580799 1.5846990664609 0.303448275862069 22.2 22 2 single kidney 0.0302005266637569 0.166014921875734 1.58251628537762 0.303030303030303 22.2 22 2 cardiovascular system phenotype 0.0302005266637569 0.166014921875734 1.58251628537762 0.303030303030303 22.2 22 2 abnormal axial skeleton morphology 0.00144655545134684 0.0200566591200437 1.58043402710739 0.302631578947368 22.2 22 2 abnormal organ of Corti morphology 0.0148194511148282 0.108360944640452 1.57883601494651 0.302325581395349 22.2 22 2 abnormal axon guidance 0.0148194511148282 0.108360944640452 1.57883601494651 0.302325581395349 22.2 22 2 abnormal double-strand DNA break repair 0.0148194511148282 0.108360944640452 1.57883601494651 0.302325581395349 22.2 22 2 postnatal growth retardation 8.55362835763244e-19 4.1038300595679e-16 1.57863756899189 0.302287581699346 22.2 22 2 enlarged kidney 0.00741701771242085 0.0641767374192068 1.57654452581016 0.30188679245283 22.2 22 2 reduced female fertility 5.51078400306399e-08 3.97335513264397e-06 1.57569509449237 0.301724137931034 22.2 22 2 decreased susceptibility to hepatic steatosis 0.00376164007686939 0.0403322400483302 1.57498049354249 0.301587301587302 22.2 22 2 increased monocyte cell number 0.000354979517227462 0.00687168520702967 1.56669112252384 0.3 22.2 22 2 thick epidermis 0.00256532863719834 0.0309769659467518 1.56669112252384 0.3 22.2 22 2 abnormal kidney development 0.00502718161143545 0.0480965933017142 1.56669112252384 0.3 22.2 22 2 abnormal eating behavior 0.00502718161143545 0.0480965933017142 1.56669112252384 0.3 22.2 22 2 muscular ventricular septal defect 0.00502718161143545 0.0480965933017142 1.56669112252384 0.3 22.2 22 2 perinatal lethality 0.0200262792038555 0.133553269489519 1.56669112252384 0.3 22.2 22 2 delayed eyelid opening 0.0412329761853236 0.205339395917903 1.56669112252384 0.3 22.2 22 2 abnormal spleen marginal zone morphology 0.0412329761853236 0.205339395917903 1.56669112252384 0.3 22.2 22 2 abnormal microglial cell physiology 0.0412329761853236 0.205339395917903 1.56669112252384 0.3 22.2 22 2 abnormal pericardium morphology 0.0884554164323055 0.323577718199059 1.56669112252384 0.3 22.2 22 2 waved hair 0.0884554164323055 0.323577718199059 1.56669112252384 0.3 22.2 22 2 increased mammary adenocarcinoma incidence 0.0884554164323055 0.323577718199059 1.56669112252384 0.3 22.2 22 2 anencephaly 0.0884554164323055 0.323577718199059 1.56669112252384 0.3 22.2 22 2 abnormal dopamine level 0.0884554164323055 0.323577718199059 1.56669112252384 0.3 22.2 22 2 abnormal hair texture 0.0884554164323055 0.323577718199059 1.56669112252384 0.3 22.2 22 2 decreased paired-pulse facilitation 0.0884554164323055 0.323577718199059 1.56669112252384 0.3 22.2 22 2 decreased myocardial infarction size 0.0884554164323055 0.323577718199059 1.56669112252384 0.3 22.2 22 2 abnormal hyoid bone morphology 0.0884554164323055 0.323577718199059 1.56669112252384 0.3 22.2 22 2 abnormal heart right ventricle morphology 0.0884554164323055 0.323577718199059 1.56669112252384 0.3 22.2 22 2 abnormal optic stalk morphology 0.0884554164323055 0.323577718199059 1.56669112252384 0.3 22.2 22 2 kidney atrophy 0.0884554164323055 0.323577718199059 1.56669112252384 0.3 22.2 22 2 abnormal enzyme/coenzyme activity 9.80888754844736e-06 0.000359757338223468 1.56336481440808 0.299363057324841 22.2 22 2 abnormal spleen morphology 3.6046386734162e-06 0.000151975232205471 1.56068847454483 0.298850574712644 22.2 22 2 hepatic necrosis 0.0133842991577113 0.101970732480266 1.55557983796694 0.297872340425532 22.2 22 2 increased food intake 0.00120104975629456 0.01702342603295 1.55425706599588 0.297619047619048 22.2 22 2 abnormal bone mineralization 0.000116939365176662 0.00278360450599949 1.55374326200712 0.297520661157025 22.2 22 2 increased circulating phosphate level 0.0271178799061612 0.154008507457936 1.55257678808669 0.297297297297297 22.2 22 2 abnormal respiratory electron transport chain 0.0271178799061612 0.154008507457936 1.55257678808669 0.297297297297297 22.2 22 2 small spleen 0.000824075165848813 0.0129330408520437 1.54947473656204 0.296703296703297 22.2 22 2 decreased body weight 2.50957032983208e-34 4.16170413030487e-31 1.5481304307115 0.296445880452342 22.2 22 2 abnormal trigeminal nerve morphology 0.0565111691991057 0.249058385054933 1.54734925681367 0.296296296296296 22.2 22 2 abnormal eye muscle morphology 0.0565111691991057 0.249058385054933 1.54734925681367 0.296296296296296 22.2 22 2 thick interventricular septum 0.0565111691991057 0.249058385054933 1.54734925681367 0.296296296296296 22.2 22 2 decreased bone ossification 0.0565111691991057 0.249058385054933 1.54734925681367 0.296296296296296 22.2 22 2 abnormal myelopoiesis 0.0180143948028907 0.120621284178171 1.54295337824318 0.295454545454545 22.2 22 2 abnormal astrocyte morphology 0.0180143948028907 0.120621284178171 1.54295337824318 0.295454545454545 22.2 22 2 muscular atrophy 0.0180143948028907 0.120621284178171 1.54295337824318 0.295454545454545 22.2 22 2 abnormal photoreceptor outer segment morphology 0.0180143948028907 0.120621284178171 1.54295337824318 0.295454545454545 22.2 22 2 abnormal bone structure 1.912961927387e-06 8.97828829127389e-05 1.54233841077477 0.295336787564767 22.2 22 2 postnatal lethality 9.83457246198827e-06 0.000359757338223468 1.54152339364796 0.295180722891566 22.2 22 2 impaired glucose tolerance 8.79725304352982e-08 6.078657484939e-06 1.53721037559463 0.294354838709677 22.2 22 2 abnormal trophoblast layer morphology 0.0120564681344643 0.0946084436290266 1.53597168874887 0.294117647058824 22.2 22 2 abnormal bone remodeling 0.0368067537591346 0.187232719787009 1.53597168874887 0.294117647058824 22.2 22 2 abnormal direction of heart looping 0.0368067537591346 0.187232719787009 1.53597168874887 0.294117647058824 22.2 22 2 abnormal skin physiology 0.0368067537591346 0.187232719787009 1.53597168874887 0.294117647058824 22.2 22 2 distended urinary bladder 0.124107178044285 0.402498833618199 1.53597168874887 0.294117647058824 22.2 22 2 abnormal glutamate-mediated receptor currents 0.124107178044285 0.402498833618199 1.53597168874887 0.294117647058824 22.2 22 2 increased regulatory T cell number 0.124107178044285 0.402498833618199 1.53597168874887 0.294117647058824 22.2 22 2 abnormal melanosome morphology 0.124107178044285 0.402498833618199 1.53597168874887 0.294117647058824 22.2 22 2 decreased growth hormone level 0.124107178044285 0.402498833618199 1.53597168874887 0.294117647058824 22.2 22 2 increased brain size 0.124107178044285 0.402498833618199 1.53597168874887 0.294117647058824 22.2 22 2 abnormal survival 0.124107178044285 0.402498833618199 1.53597168874887 0.294117647058824 22.2 22 2 abnormal neurocranium morphology 0.00280621533505228 0.0329267011601063 1.53187576424554 0.293333333333333 22.2 22 2 liver fibrosis 0.0242822484472685 0.150816711641899 1.5284791439257 0.292682926829268 22.2 22 2 decreased leukocyte cell number 8.02514960100202e-05 0.00205799583840129 1.52476021656822 0.291970802919708 22.2 22 2 abnormal forebrain development 0.00372514238600336 0.0403322400483302 1.52317192467596 0.291666666666667 22.2 22 2 abnormal body weight 0.0778088172144741 0.302420988782819 1.52317192467596 0.291666666666667 22.2 22 2 ocular hypertelorism 0.0778088172144741 0.302420988782819 1.52317192467596 0.291666666666667 22.2 22 2 hemolytic anemia 0.0778088172144741 0.302420988782819 1.52317192467596 0.291666666666667 22.2 22 2 apnea 0.0778088172144741 0.302420988782819 1.52317192467596 0.291666666666667 22.2 22 2 decreased ovulation rate 0.0778088172144741 0.302420988782819 1.52317192467596 0.291666666666667 22.2 22 2 abnormal cellular extravasation 0.0778088172144741 0.302420988782819 1.52317192467596 0.291666666666667 22.2 22 2 abnormal inner cell mass apoptosis 0.0778088172144741 0.302420988782819 1.52317192467596 0.291666666666667 22.2 22 2 decreased body size 7.66434229064079e-21 5.44715755656256e-18 1.51826374446755 0.290726817042607 22.2 22 2 increased circulating creatinine level 0.0017314723590695 0.0224324869436738 1.51811155283318 0.290697674418605 22.2 22 2 increased B cell number 0.000291413442931113 0.00584589467170276 1.51759254033649 0.290598290598291 22.2 22 2 abnormal liver morphology 8.85003479251767e-06 0.000336098649563171 1.51709382441788 0.290502793296089 22.2 22 2 increased lung adenoma incidence 0.0500925627634944 0.234440733535639 1.51615269921662 0.290322580645161 22.2 22 2 abnormal retinal photoreceptor layer morphology 0.0500925627634944 0.234440733535639 1.51615269921662 0.290322580645161 22.2 22 2 abnormal CD8-positive, alpha beta T cell morphology 0.0500925627634944 0.234440733535639 1.51615269921662 0.290322580645161 22.2 22 2 abnormal T cell proliferation 0.0500925627634944 0.234440733535639 1.51615269921662 0.290322580645161 22.2 22 2 abnormal mitochondrial ATP synthesis coupled electron transport 0.0500925627634944 0.234440733535639 1.51615269921662 0.290322580645161 22.2 22 2 abnormal liver physiology 0.000812057263634708 0.0127847622993122 1.51446808510638 0.29 22.2 22 2 decreased double-positive T cell number 0.000812057263634708 0.0127847622993122 1.51446808510638 0.29 22.2 22 2 increased circulating triglyceride level 6.61034777692097e-05 0.00174002540688793 1.51266729071268 0.289655172413793 22.2 22 2 increased grooming behavior 0.032785309528307 0.169022709744381 1.51171950418967 0.289473684210526 22.2 22 2 decreased total retina thickness 0.032785309528307 0.169022709744381 1.51171950418967 0.289473684210526 22.2 22 2 decreased circulating HDL cholesterol level 0.000181958873522346 0.00400551060076845 1.5095721753485 0.2890625 22.2 22 2 decreased insulin secretion 0.00156396799955493 0.0210860184221836 1.50866552539333 0.288888888888889 22.2 22 2 abnormal cartilage development 0.0217021948610151 0.139674540017529 1.50866552539333 0.288888888888889 22.2 22 2 increased circulating corticosterone level 0.0217021948610151 0.139674540017529 1.50866552539333 0.288888888888889 22.2 22 2 lethality at weaning, complete penetrance 0.0217021948610151 0.139674540017529 1.50866552539333 0.288888888888889 22.2 22 2 abnormal spermatogenesis 9.54106124724598e-06 0.000356893080489088 1.50425053430731 0.28804347826087 22.2 22 2 insulin resistance 0.000164735933796663 0.0036917174353081 1.50339047110874 0.287878787878788 22.2 22 2 reduced fertility 0.000113691136001226 0.00273243189181691 1.50282122064637 0.287769784172662 22.2 22 2 abnormal eye morphology 0.000113691136001226 0.00273243189181691 1.50282122064637 0.287769784172662 22.2 22 2 abnormal seminiferous tubule morphology 7.85311859815444e-05 0.0020243142500424 1.50230655584478 0.287671232876712 22.2 22 2 ataxia 4.16200147090262e-06 0.000168341116404394 1.49947335159048 0.287128712871287 22.2 22 2 hydroencephaly 0.00045580606553447 0.00834759790031861 1.49857411719672 0.28695652173913 22.2 22 2 abnormal skeleton morphology 0.00045580606553447 0.00834759790031861 1.49857411719672 0.28695652173913 22.2 22 2 abnormal coat/hair pigmentation 0.000598697932817438 0.0102707662612647 1.49208678335604 0.285714285714286 22.2 22 2 abnormal seminal vesicle morphology 0.012962202197585 0.100918553885736 1.49208678335604 0.285714285714286 22.2 22 2 abnormal circulating cholesterol level 0.068389258807607 0.275758674371201 1.49208678335604 0.285714285714286 22.2 22 2 shortened head 0.068389258807607 0.275758674371201 1.49208678335604 0.285714285714286 22.2 22 2 abnormal somite shape 0.068389258807607 0.275758674371201 1.49208678335604 0.285714285714286 22.2 22 2 abnormal hormone level 0.068389258807607 0.275758674371201 1.49208678335604 0.285714285714286 22.2 22 2 increased bone resorption 0.068389258807607 0.275758674371201 1.49208678335604 0.285714285714286 22.2 22 2 hypoxia 0.068389258807607 0.275758674371201 1.49208678335604 0.285714285714286 22.2 22 2 subcutaneous edema 0.068389258807607 0.275758674371201 1.49208678335604 0.285714285714286 22.2 22 2 increased circulating HDL cholesterol level 0.00087205084192097 0.0134317428438292 1.49208678335604 0.285714285714286 22.2 22 2 abnormal humoral immune response 0.00087205084192097 0.0134317428438292 1.49208678335604 0.285714285714286 22.2 22 2 polyuria 0.00400279506263881 0.0417482294268933 1.49208678335604 0.285714285714286 22.2 22 2 abnormal embryonic epiblast morphology 0.0443485114999627 0.212039546499521 1.49208678335604 0.285714285714286 22.2 22 2 decreased triglyceride level 0.0443485114999627 0.212039546499521 1.49208678335604 0.285714285714286 22.2 22 2 abnormal cartilage morphology 0.0291648875886336 0.163395625848482 1.49208678335604 0.285714285714286 22.2 22 2 abnormal vibrissa morphology 0.0291648875886336 0.163395625848482 1.49208678335604 0.285714285714286 22.2 22 2 abnormal reproductive system morphology 0.0291648875886336 0.163395625848482 1.49208678335604 0.285714285714286 22.2 22 2 increased incidence of induced tumors 0.107743635651094 0.384798698753906 1.49208678335604 0.285714285714286 22.2 22 2 abnormal embryonic/fetal subventricular zone morphology 0.107743635651094 0.384798698753906 1.49208678335604 0.285714285714286 22.2 22 2 abnormal clavicle morphology 0.107743635651094 0.384798698753906 1.49208678335604 0.285714285714286 22.2 22 2 decreased body length 1.52197397973517e-07 9.9629217752401e-06 1.48664121115401 0.284671532846715 22.2 22 2 decreased anxiety-related response 0.000371487576888133 0.0070810371456646 1.48602138992777 0.284552845528455 22.2 22 2 abnormal renal glomerulus morphology 0.000786145637544623 0.0124778507295718 1.48524234857001 0.284403669724771 22.2 22 2 increased inflammatory response 0.0016742706174568 0.0220378700347899 1.48423369502259 0.284210526315789 22.2 22 2 increased T cell number 0.00245071826608514 0.0297373740823746 1.48360901754152 0.284090909090909 22.2 22 2 decreased compact bone thickness 0.00781469945048804 0.065341394565005 1.48095180736085 0.283582089552239 22.2 22 2 decreased white adipose tissue amount 0.00781469945048804 0.065341394565005 1.48095180736085 0.283582089552239 22.2 22 2 abnormal placenta development 0.0172753158519595 0.117571404054033 1.47801049294702 0.283018867924528 22.2 22 2 increased circulating bilirubin level 0.0172753158519595 0.117571404054033 1.47801049294702 0.283018867924528 22.2 22 2 abnormal motor coordination/ balance 0.00150612527100132 0.0207561585131068 1.47701519968578 0.282828282828283 22.2 22 2 abnormal inner ear morphology 0.0259236769397387 0.152808403762085 1.47586844875435 0.282608695652174 22.2 22 2 cardiac fibrosis 0.0032283595690398 0.0369220433470644 1.47453282119891 0.282352941176471 22.2 22 2 abnormal leukocyte adhesion 0.0392418121641127 0.197599205988321 1.47295746562071 0.282051282051282 22.2 22 2 abnormal response to injury 0.0392418121641127 0.197599205988321 1.47295746562071 0.282051282051282 22.2 22 2 reduced male fertility 2.69339371051471e-06 0.000120272204915524 1.47236757476543 0.281938325991189 22.2 22 2 increased circulating free fatty acid level 0.00699546844032935 0.0619260773854778 1.47107147654821 0.28169014084507 22.2 22 2 decreased lymphocyte cell number 0.000394965626451097 0.00747130795282969 1.4687729273661 0.28125 22.2 22 2 retinal degeneration 0.0019783295152464 0.0251076258631399 1.4687729273661 0.28125 22.2 22 2 decreased circulating LDL cholesterol level 0.0103537752197475 0.0829469109794587 1.4687729273661 0.28125 22.2 22 2 neonatal lethality 0.0601160668891606 0.261402323569347 1.4687729273661 0.28125 22.2 22 2 abnormal lumbar vertebrae morphology 0.0601160668891606 0.261402323569347 1.4687729273661 0.28125 22.2 22 2 abnormal serotonin level 0.0601160668891606 0.261402323569347 1.4687729273661 0.28125 22.2 22 2 neonatal lethality, complete penetrance 5.43642524555447e-11 6.4395751420556e-09 1.46590982224453 0.280701754385965 22.2 22 2 decreased brain weight 0.0153968167654238 0.109572697781098 1.46590982224453 0.280701754385965 22.2 22 2 no abnormal phenotype detected 1.24907621466036e-38 3.10707708396764e-35 1.46585701569474 0.280691642651297 22.2 22 2 increased heart weight 0.000245086841738353 0.00501772443476669 1.46525069013021 0.280575539568345 22.2 22 2 abnormal excitatory postsynaptic potential 0.00425150771424289 0.0423962610617859 1.4647925129288 0.280487804878049 22.2 22 2 limb grasping 3.14441090069455e-05 0.00097771526443471 1.46339280675304 0.28021978021978 22.2 22 2 abnormal circulating protein level 0.023032142296518 0.145117822553305 1.46224504768892 0.28 22.2 22 2 abnormal inner ear vestibule morphology 0.0937163952971231 0.341817497509668 1.46224504768892 0.28 22.2 22 2 mandible hypoplasia 0.0937163952971231 0.341817497509668 1.46224504768892 0.28 22.2 22 2 abnormal cochlear outer hair cell morphology 0.0937163952971231 0.341817497509668 1.46224504768892 0.28 22.2 22 2 decreased IgG level 0.00109286629575257 0.0160383770541859 1.45848122517235 0.279279279279279 22.2 22 2 abnormal homeostasis 0.0347179597720421 0.17733249472886 1.45738709071986 0.27906976744186 22.2 22 2 abnormal blood circulation 0.0347179597720421 0.17733249472886 1.45738709071986 0.27906976744186 22.2 22 2 abnormal myocardial fiber morphology 0.0023284510324579 0.0284620242911008 1.45363093842419 0.278350515463918 22.2 22 2 abnormal maxilla morphology 0.0204583297905869 0.135888105084339 1.45063992826282 0.277777777777778 22.2 22 2 reduced long term depression 0.0528705794569655 0.24490794487747 1.45063992826282 0.277777777777778 22.2 22 2 abnormal limb bone morphology 0.0528705794569655 0.24490794487747 1.45063992826282 0.277777777777778 22.2 22 2 narrow eye opening 0.0528705794569655 0.24490794487747 1.45063992826282 0.277777777777778 22.2 22 2 abnormal heart shape 0.150267024493799 0.429861879748913 1.45063992826282 0.277777777777778 22.2 22 2 thick dermal layer 0.150267024493799 0.429861879748913 1.45063992826282 0.277777777777778 22.2 22 2 absent allantois 0.150267024493799 0.429861879748913 1.45063992826282 0.277777777777778 22.2 22 2 absent ureter 0.150267024493799 0.429861879748913 1.45063992826282 0.277777777777778 22.2 22 2 jerky movement 0.150267024493799 0.429861879748913 1.45063992826282 0.277777777777778 22.2 22 2 increased effector memory CD4-positive, alpha-beta T cell number 0.150267024493799 0.429861879748913 1.45063992826282 0.277777777777778 22.2 22 2 increased effector memory CD8-positive, alpha-beta T cell number 0.150267024493799 0.429861879748913 1.45063992826282 0.277777777777778 22.2 22 2 abnormal metanephric mesenchyme morphology 0.150267024493799 0.429861879748913 1.45063992826282 0.277777777777778 22.2 22 2 decreased B cell number 1.68015998682919e-05 0.000564783509086164 1.44500637514335 0.276699029126214 22.2 22 2 increased systemic arterial blood pressure 0.0307181449152197 0.166014921875734 1.44446699239787 0.276595744680851 22.2 22 2 increased blood urea nitrogen level 0.000302476324251396 0.00599529766195496 1.44063551496445 0.275862068965517 22.2 22 2 increased susceptibility to induced arthritis 0.0816830754050849 0.313317887540707 1.44063551496445 0.275862068965517 22.2 22 2 short sternum 0.0816830754050849 0.313317887540707 1.44063551496445 0.275862068965517 22.2 22 2 decreased bone strength 0.0816830754050849 0.313317887540707 1.44063551496445 0.275862068965517 22.2 22 2 abnormal skin pigmentation 0.0465304625973137 0.220465763258701 1.43613352898019 0.275 22.2 22 2 increased susceptibility to weight loss 0.0465304625973137 0.220465763258701 1.43613352898019 0.275 22.2 22 2 abnormal gluconeogenesis 0.0271851000875653 0.154214222275527 1.43357357616561 0.274509803921569 22.2 22 2 weight loss 9.41548771722664e-05 0.00233045031806978 1.4324033120218 0.274285714285714 22.2 22 2 prenatal lethality 0.0161389419279629 0.112927195628151 1.43192199370459 0.274193548387097 22.2 22 2 decreased bone mineral content 2.28100116796965e-05 0.000741698092199281 1.43111208307467 0.274038461538462 22.2 22 2 decreased birth weight 0.00356995960627443 0.039929213140678 1.42926207668842 0.273684210526316 22.2 22 2 abnormal cytokine secretion 0.000283778177732766 0.00571577503733 1.42426465683986 0.272727272727273 22.2 22 2 increased sensitivity to xenobiotic induced morbidity/mortality 0.00195353863256804 0.0248564058747468 1.42426465683986 0.272727272727273 22.2 22 2 hyperglycemia 0.00522984200371469 0.0494647603963509 1.42426465683986 0.272727272727273 22.2 22 2 increased liver weight 0.00522984200371469 0.0494647603963509 1.42426465683986 0.272727272727273 22.2 22 2 increased circulating calcium level 0.0240656093204935 0.149658007961819 1.42426465683986 0.272727272727273 22.2 22 2 abnormal platelet physiology 0.0240656093204935 0.149658007961819 1.42426465683986 0.272727272727273 22.2 22 2 abnormal T-helper 2 physiology 0.0240656093204935 0.149658007961819 1.42426465683986 0.272727272727273 22.2 22 2 osteoporosis 0.040981796635474 0.204703251266549 1.42426465683986 0.272727272727273 22.2 22 2 hypertension 0.040981796635474 0.204703251266549 1.42426465683986 0.272727272727273 22.2 22 2 abnormal circadian rhythm 0.040981796635474 0.204703251266549 1.42426465683986 0.272727272727273 22.2 22 2 decreased macrophage cell number 0.040981796635474 0.204703251266549 1.42426465683986 0.272727272727273 22.2 22 2 decreased brown adipose tissue amount 0.0713343944736869 0.280544357712721 1.42426465683986 0.272727272727273 22.2 22 2 decreased systemic arterial blood pressure 0.0713343944736869 0.280544357712721 1.42426465683986 0.272727272727273 22.2 22 2 abnormal locomotor coordination 0.0713343944736869 0.280544357712721 1.42426465683986 0.272727272727273 22.2 22 2 abnormal QRS complex 0.0713343944736869 0.280544357712721 1.42426465683986 0.272727272727273 22.2 22 2 abnormal middle ear ossicle morphology 0.0713343944736869 0.280544357712721 1.42426465683986 0.272727272727273 22.2 22 2 increased body size 0.128992828090719 0.415365255502477 1.42426465683986 0.272727272727273 22.2 22 2 increased skin papilloma incidence 0.128992828090719 0.415365255502477 1.42426465683986 0.272727272727273 22.2 22 2 abnormal tracheal cartilage morphology 0.128992828090719 0.415365255502477 1.42426465683986 0.272727272727273 22.2 22 2 parakeratosis 0.128992828090719 0.415365255502477 1.42426465683986 0.272727272727273 22.2 22 2 prolonged PR interval 0.128992828090719 0.415365255502477 1.42426465683986 0.272727272727273 22.2 22 2 abnormal limb posture 0.128992828090719 0.415365255502477 1.42426465683986 0.272727272727273 22.2 22 2 decreased susceptibility to viral infection induced morbidity/mortality 0.128992828090719 0.415365255502477 1.42426465683986 0.272727272727273 22.2 22 2 increased body weight 1.48679339966462e-05 0.000510123942298723 1.42214521538623 0.272321428571429 22.2 22 2 embryonic lethality before implantation, complete penetrance 0.00107499976388359 0.0159068463382073 1.42046661775495 0.272 22.2 22 2 abnormal locomotor behavior 0.00466503355734863 0.0460486943408918 1.41910427764841 0.271739130434783 22.2 22 2 abnormal skeleton development 0.007681223802668 0.0644794663752601 1.41840348541253 0.271604938271605 22.2 22 2 abnormal thoracic vertebrae morphology 0.0213114161007574 0.137872945515303 1.41621796386336 0.271186440677966 22.2 22 2 abnormal intestinal epithelium morphology 0.0361227546786717 0.18431867130912 1.41437393005625 0.270833333333333 22.2 22 2 increased brown adipose tissue amount 0.0624086163276338 0.265824371772242 1.41143344371518 0.27027027027027 22.2 22 2 abnormal hair follicle development 0.0624086163276338 0.265824371772242 1.41143344371518 0.27027027027027 22.2 22 2 skin inflammation 0.0624086163276338 0.265824371772242 1.41143344371518 0.27027027027027 22.2 22 2 enlarged liver 0.00371167485958929 0.0403322400483302 1.41002201027146 0.27 22.2 22 2 abnormal nervous system physiology 0.00202940629683831 0.0254020982577688 1.40775144342722 0.269565217391304 22.2 22 2 abnormal lipid homeostasis 0.00111601676510504 0.0161871236338122 1.40600485354704 0.269230769230769 22.2 22 2 increased urine protein level 0.0100563796627152 0.0808246992277999 1.40600485354704 0.269230769230769 22.2 22 2 abnormal brain wave pattern 0.0318639990508833 0.166014921875734 1.40600485354704 0.269230769230769 22.2 22 2 abnormal stomach morphology 0.111285389987375 0.394614978750671 1.40600485354704 0.269230769230769 22.2 22 2 no spontaneous movement 0.111285389987375 0.394614978750671 1.40600485354704 0.269230769230769 22.2 22 2 increased susceptibility to otitis media 0.111285389987375 0.394614978750671 1.40600485354704 0.269230769230769 22.2 22 2 abnormal ocular fundus morphology 0.111285389987375 0.394614978750671 1.40600485354704 0.269230769230769 22.2 22 2 decreased circulating glycerol level 0.111285389987375 0.394614978750671 1.40600485354704 0.269230769230769 22.2 22 2 abnormal erythrocyte osmotic lysis 0.111285389987375 0.394614978750671 1.40600485354704 0.269230769230769 22.2 22 2 sparse hair 0.00893878636842383 0.0730221053906544 1.40110588193189 0.268292682926829 22.2 22 2 thick ventricular wall 0.054688141118997 0.249058385054933 1.40110588193189 0.268292682926829 22.2 22 2 small testis 3.65220405325174e-06 0.000152686682058214 1.40018288727976 0.268115942028986 22.2 22 2 reduced long term potentiation 0.00263461605693297 0.0315836503210639 1.39883135939629 0.267857142857143 22.2 22 2 abnormal eye development 0.0281278314386307 0.159380366067412 1.39883135939629 0.267857142857143 22.2 22 2 corneal opacity 0.0148329252864619 0.108360944640452 1.3975179027208 0.267605633802817 22.2 22 2 abnormal CD4-positive, alpha-beta T cell physiology 0.0148329252864619 0.108360944640452 1.3975179027208 0.267605633802817 22.2 22 2 abnormal T cell differentiation 0.00430464582000111 0.0428312259090111 1.39606139630838 0.267326732673267 22.2 22 2 kyphosis 0.000636998362891234 0.0107791389638908 1.39261433113231 0.266666666666667 22.2 22 2 oxidative stress 0.00706674343196561 0.0623351925071435 1.39261433113231 0.266666666666667 22.2 22 2 increased susceptibility to parasitic infection 0.00706674343196561 0.0623351925071435 1.39261433113231 0.266666666666667 22.2 22 2 abnormal ovarian follicle morphology 0.0479925609170954 0.226745480116382 1.39261433113231 0.266666666666667 22.2 22 2 abnormal estrous cycle 0.096392202394089 0.349633285388811 1.39261433113231 0.266666666666667 22.2 22 2 enhanced paired-pulse facilitation 0.096392202394089 0.349633285388811 1.39261433113231 0.266666666666667 22.2 22 2 liver hemorrhage 0.096392202394089 0.349633285388811 1.39261433113231 0.266666666666667 22.2 22 2 abnormal optic cup morphology 0.096392202394089 0.349633285388811 1.39261433113231 0.266666666666667 22.2 22 2 increased sensitivity to induced morbidity/mortality 0.000175717212088442 0.00390264790241071 1.39072219209544 0.266304347826087 22.2 22 2 abnormal behavior 4.841391485235e-06 0.000194241311605195 1.3901096290979 0.266187050359712 22.2 22 2 decreased caudal vertebrae number 0.0219630790470969 0.141170953823394 1.38717443140132 0.265625 22.2 22 2 increased circulating LDL cholesterol level 0.0421719099446727 0.207849682559462 1.38550915597347 0.26530612244898 22.2 22 2 increased T cell derived lymphoma incidence 0.0421719099446727 0.207849682559462 1.38550915597347 0.26530612244898 22.2 22 2 respiratory failure 0.000734005252110634 0.011741723888265 1.38339171966785 0.264900662251656 22.2 22 2 cataract 0.00241904813484907 0.0294248520070272 1.38110512178411 0.264462809917355 22.2 22 2 abnormal mesoderm development 0.037100962250497 0.188152178589422 1.37947646008389 0.264150943396226 22.2 22 2 abnormal neuromuscular synapse morphology 0.0171916638435501 0.117323083157287 1.37810793184968 0.263888888888889 22.2 22 2 abnormal heart left ventricle morphology 0.0171916638435501 0.117323083157287 1.37810793184968 0.263888888888889 22.2 22 2 abnormal B cell differentiation 0.00816675465929115 0.0679039769945654 1.37731087694404 0.263736263736264 22.2 22 2 abnormal blood homeostasis 0.00350878415130541 0.0394045172748181 1.37429045835425 0.263157894736842 22.2 22 2 alopecia 0.00725503847932734 0.0635454514694604 1.37429045835425 0.263157894736842 22.2 22 2 abnormal compact bone morphology 0.0729883687559649 0.286369979937638 1.37429045835425 0.263157894736842 22.2 22 2 irregular coat pigmentation 0.178497795410705 0.457981708183733 1.37429045835425 0.263157894736842 22.2 22 2 flaky skin 0.178497795410705 0.457981708183733 1.37429045835425 0.263157894736842 22.2 22 2 abnormal stationary movement 0.178497795410705 0.457981708183733 1.37429045835425 0.263157894736842 22.2 22 2 oliguria 0.178497795410705 0.457981708183733 1.37429045835425 0.263157894736842 22.2 22 2 increased left ventricle weight 0.178497795410705 0.457981708183733 1.37429045835425 0.263157894736842 22.2 22 2 decreased fertilization frequency 0.178497795410705 0.457981708183733 1.37429045835425 0.263157894736842 22.2 22 2 right-sided stomach 0.178497795410705 0.457981708183733 1.37429045835425 0.263157894736842 22.2 22 2 embryonic lethality between implantation and somite formation, incomplete penetrance 0.178497795410705 0.457981708183733 1.37429045835425 0.263157894736842 22.2 22 2 hypoactivity 2.72305993068751e-07 1.6321955608639e-05 1.37137419212963 0.262599469496021 22.2 22 2 increased circulating insulin level 0.000672568698650034 0.0109214385437045 1.37085473220836 0.2625 22.2 22 2 abnormal male meiosis 0.0288042500770892 0.162842209242635 1.36978458799899 0.262295081967213 22.2 22 2 abnormal NK cell physiology 0.0288042500770892 0.162842209242635 1.36978458799899 0.262295081967213 22.2 22 2 abnormal retina morphology 0.000118641396581882 0.00281067118092791 1.36774621807637 0.261904761904762 22.2 22 2 abnormal dendritic cell physiology 0.00509515666522685 0.0483748175753885 1.36658415671862 0.261682242990654 22.2 22 2 microphthalmia 0.000967892254002016 0.0146360606798177 1.36530816777677 0.261437908496732 22.2 22 2 abnormal coat appearance 0.0224421540129851 0.143325166846501 1.36234010654247 0.260869565217391 22.2 22 2 delayed wound healing 0.0557815787914566 0.249058385054933 1.36234010654247 0.260869565217391 22.2 22 2 abnormal lymphocyte physiology 0.0557815787914566 0.249058385054933 1.36234010654247 0.260869565217391 22.2 22 2 fragile skeleton 0.152074364910278 0.429861879748913 1.36234010654247 0.260869565217391 22.2 22 2 hypotension 0.152074364910278 0.429861879748913 1.36234010654247 0.260869565217391 22.2 22 2 failure of embryo implantation 0.152074364910278 0.429861879748913 1.36234010654247 0.260869565217391 22.2 22 2 abnormal sacral vertebrae morphology 0.152074364910278 0.429861879748913 1.36234010654247 0.260869565217391 22.2 22 2 decreased epididymis weight 0.152074364910278 0.429861879748913 1.36234010654247 0.260869565217391 22.2 22 2 abnormal palatal shelf fusion at midline 0.152074364910278 0.429861879748913 1.36234010654247 0.260869565217391 22.2 22 2 decreased effector memory CD8-positive, alpha-beta T cell number 0.152074364910278 0.429861879748913 1.36234010654247 0.260869565217391 22.2 22 2 abnormal trabecular bone morphology 0.003586593190984 0.039929213140678 1.36043206717757 0.260504201680672 22.2 22 2 cyanosis 0.00027215913498948 0.00553897236341656 1.35997493274639 0.260416666666667 22.2 22 2 abnormal fertility/fecundity 0.0198319013894908 0.132434509278815 1.35922974100242 0.26027397260274 22.2 22 2 increased circulating chloride level 0.0488966931724027 0.230360841413545 1.357798972854 0.26 22.2 22 2 testicular atrophy 0.0488966931724027 0.230360841413545 1.357798972854 0.26 22.2 22 2 abnormal axon extension 0.0488966931724027 0.230360841413545 1.357798972854 0.26 22.2 22 2 obese 0.0175371587331002 0.119190388930565 1.35644253032367 0.25974025974026 22.2 22 2 decreased heart weight 0.0155176609068616 0.10965960655062 1.35393059971196 0.259259259259259 22.2 22 2 impaired limb coordination 0.0429258836114655 0.207849682559462 1.35393059971196 0.259259259259259 22.2 22 2 abnormal long bone epiphyseal plate proliferative zone 0.0429258836114655 0.207849682559462 1.35393059971196 0.259259259259259 22.2 22 2 abnormal atrioventricular cushion morphology 0.13045636726327 0.418183264906421 1.35393059971196 0.259259259259259 22.2 22 2 abnormal palate morphology 0.13045636726327 0.418183264906421 1.35393059971196 0.259259259259259 22.2 22 2 postnatal lethality, complete penetrance 4.71242624825681e-07 2.63419332416603e-05 1.35292843050418 0.259067357512953 22.2 22 2 dermatitis 0.0377341680511074 0.190586280258131 1.35059579527918 0.258620689655172 22.2 22 2 thrombocytosis 0.0377341680511074 0.190586280258131 1.35059579527918 0.258620689655172 22.2 22 2 lethargy 0.0107861412118103 0.0855838158353371 1.34769128819255 0.258064516129032 22.2 22 2 abnormal eyelid morphology 0.112496424874296 0.395363960536524 1.34769128819255 0.258064516129032 22.2 22 2 abnormal podocyte morphology 0.112496424874296 0.395363960536524 1.34769128819255 0.258064516129032 22.2 22 2 azoospermia 0.00112757150391739 0.0162599079188087 1.34663178246284 0.257861635220126 22.2 22 2 abnormal skin morphology 0.0292584892838529 0.163735640255532 1.34513884257098 0.257575757575758 22.2 22 2 decreased circulating cholesterol level 0.000567290165971541 0.00976563521006372 1.34124740908234 0.256830601092896 22.2 22 2 abnormal intestine morphology 0.0227737829250865 0.145069872025999 1.34086177152942 0.256756756756757 22.2 22 2 increased bone mineral density 0.00593595911076333 0.055510143939939 1.34023724345698 0.256637168141593 22.2 22 2 abnormal cornea morphology 0.0201167377228882 0.133976934633693 1.33905224147337 0.256410256410256 22.2 22 2 small lens 0.0846251124083275 0.322648377226027 1.33905224147337 0.256410256410256 22.2 22 2 impaired macrophage chemotaxis 0.0846251124083275 0.322648377226027 1.33905224147337 0.256410256410256 22.2 22 2 decreased B-1 B cell number 0.0846251124083275 0.322648377226027 1.33905224147337 0.256410256410256 22.2 22 2 impaired macrophage phagocytosis 0.0737227487391316 0.288386211644568 1.3359381664932 0.255813953488372 22.2 22 2 decreased oxygen consumption 0.0737227487391316 0.288386211644568 1.3359381664932 0.255813953488372 22.2 22 2 increased circulating glucose level 0.00260816916710811 0.0314180184173435 1.3333541468288 0.25531914893617 22.2 22 2 abnormal tibia morphology 0.0643747561204521 0.273001713232168 1.3333541468288 0.25531914893617 22.2 22 2 decreased bone trabecula number 0.0643747561204521 0.273001713232168 1.3333541468288 0.25531914893617 22.2 22 2 improved glucose tolerance 0.000457761133766334 0.00834759790031861 1.33222034228218 0.255102040816327 22.2 22 2 distended abdomen 0.0563243434382682 0.249058385054933 1.33117546358235 0.254901960784314 22.2 22 2 increased hemoglobin content 0.0433328334887266 0.208880827982388 1.3277043411219 0.254237288135593 22.2 22 2 abnormal ovary morphology 0.0295275105593927 0.16505546632919 1.32396432889339 0.253521126760563 22.2 22 2 abnormal limb morphology 0.0260373190731028 0.153296641880102 1.32298361457569 0.253333333333333 22.2 22 2 hunched posture 0.0229797054212644 0.145117822553305 1.32210221310029 0.253164556962025 22.2 22 2 abnormal testis morphology 0.00768569317799583 0.0644794663752601 1.31692876965772 0.252173913043478 22.2 22 2 increased anxiety-related response 0.00377685786427912 0.0404083180102981 1.31496856806558 0.251798561151079 22.2 22 2 abnormal neuron differentiation 0.00981888384395942 0.0791717133285221 1.30557593543654 0.25 22.2 22 2 cachexia 0.0124994235917688 0.0974680758135574 1.30557593543654 0.25 22.2 22 2 increased susceptibility to bacterial infection induced morbidity/mortality 0.0336394594646737 0.172354594064626 1.30557593543654 0.25 22.2 22 2 increased sacral vertebrae number 0.0434629021476111 0.209117928611572 1.30557593543654 0.25 22.2 22 2 decreased IgA level 0.0644777915673964 0.273001713232168 1.30557593543654 0.25 22.2 22 2 abnormal hair growth 0.0644777915673964 0.273001713232168 1.30557593543654 0.25 22.2 22 2 abnormal lymph node morphology 0.073792089934379 0.288386211644568 1.30557593543654 0.25 22.2 22 2 curly tail 0.073792089934379 0.288386211644568 1.30557593543654 0.25 22.2 22 2 decreased circulating phosphate level 0.0973233290119987 0.351877588542655 1.30557593543654 0.25 22.2 22 2 abnormal female reproductive system morphology 0.0973233290119987 0.351877588542655 1.30557593543654 0.25 22.2 22 2 impaired ovarian folliculogenesis 0.0973233290119987 0.351877588542655 1.30557593543654 0.25 22.2 22 2 abnormal systemic arterial blood pressure 0.112254190236537 0.395363960536524 1.30557593543654 0.25 22.2 22 2 abnormal epidermis stratum granulosum morphology 0.112254190236537 0.395363960536524 1.30557593543654 0.25 22.2 22 2 abnormal lysosome morphology 0.112254190236537 0.395363960536524 1.30557593543654 0.25 22.2 22 2 scoliosis 0.129956544202674 0.417118585424713 1.30557593543654 0.25 22.2 22 2 increased circulating follicle stimulating hormone level 0.129956544202674 0.417118585424713 1.30557593543654 0.25 22.2 22 2 bradykinesia 0.129956544202674 0.417118585424713 1.30557593543654 0.25 22.2 22 2 abnormal stria vascularis morphology 0.151145403415157 0.429861879748913 1.30557593543654 0.25 22.2 22 2 myoclonus 0.151145403415157 0.429861879748913 1.30557593543654 0.25 22.2 22 2 reddish skin 0.151145403415157 0.429861879748913 1.30557593543654 0.25 22.2 22 2 abnormal spleen germinal center morphology 0.151145403415157 0.429861879748913 1.30557593543654 0.25 22.2 22 2 straub tail 0.151145403415157 0.429861879748913 1.30557593543654 0.25 22.2 22 2 prolonged QRS complex duration 0.151145403415157 0.429861879748913 1.30557593543654 0.25 22.2 22 2 decreased body height 0.176829547475546 0.455817097767276 1.30557593543654 0.25 22.2 22 2 abnormal nursing 0.176829547475546 0.455817097767276 1.30557593543654 0.25 22.2 22 2 increased stereotypic behavior 0.176829547475546 0.455817097767276 1.30557593543654 0.25 22.2 22 2 abnormal primitive streak formation 0.176829547475546 0.455817097767276 1.30557593543654 0.25 22.2 22 2 abnormal cardiac muscle contractility 0.176829547475546 0.455817097767276 1.30557593543654 0.25 22.2 22 2 increased hemangiosarcoma incidence 0.176829547475546 0.455817097767276 1.30557593543654 0.25 22.2 22 2 decreased fatty acid level 0.176829547475546 0.455817097767276 1.30557593543654 0.25 22.2 22 2 hypopigmentation 0.176829547475546 0.455817097767276 1.30557593543654 0.25 22.2 22 2 abnormal lung saccule morphology 0.176829547475546 0.455817097767276 1.30557593543654 0.25 22.2 22 2 abnormal hearing physiology 0.208511921736838 0.50381098136997 1.30557593543654 0.25 22.2 22 2 abnormal trachea morphology 0.208511921736838 0.50381098136997 1.30557593543654 0.25 22.2 22 2 abnormal Peyer's patch T cell area morphology 0.208511921736838 0.50381098136997 1.30557593543654 0.25 22.2 22 2 decreased skin tensile strength 0.208511921736838 0.50381098136997 1.30557593543654 0.25 22.2 22 2 abnormal thymocyte activation 0.208511921736838 0.50381098136997 1.30557593543654 0.25 22.2 22 2 decreased circulating VLDL cholesterol level 0.208511921736838 0.50381098136997 1.30557593543654 0.25 22.2 22 2 enhanced behavioral response to xenobiotic 0.208511921736838 0.50381098136997 1.30557593543654 0.25 22.2 22 2 increased skin tumor incidence 0.208511921736838 0.50381098136997 1.30557593543654 0.25 22.2 22 2 abnormal heart electrocardiography waveform feature 0.208511921736838 0.50381098136997 1.30557593543654 0.25 22.2 22 2 absent ductus venosus valve 0.208511921736838 0.50381098136997 1.30557593543654 0.25 22.2 22 2 abnormal suckling behavior 0.0203882004002216 0.135603338223399 1.30557593543654 0.25 22.2 22 2 decreased exploration in new environment 0.0230786365513201 0.145117822553305 1.30557593543654 0.25 22.2 22 2 decreased neutrophil cell number 0.00984056690812739 0.0792181559351679 1.29441716675759 0.247863247863248 22.2 22 2 decreased grip strength 0.000673946056867797 0.0109214385437045 1.28769133358124 0.246575342465753 22.2 22 2 decreased percent body fat/body weight 0.0381582966529154 0.192532987675714 1.28769133358124 0.246575342465753 22.2 22 2 abnormal epidermal layer morphology 0.0433716372473983 0.208880827982388 1.28665454506789 0.246376811594203 22.2 22 2 abnormal long bone morphology 0.0562417167013538 0.249058385054933 1.28417305124905 0.245901639344262 22.2 22 2 decreased susceptibility to induced arthritis 0.0641846688794363 0.272688922011269 1.28267109446397 0.245614035087719 22.2 22 2 abnormal pancreatic islet morphology 0.0733752610953888 0.287661090582789 1.28094242722075 0.245283018867925 22.2 22 2 altered response to myocardial infarction 0.0964917589625805 0.349633285388811 1.27656313687128 0.244444444444444 22.2 22 2 abnormal ectoderm development 0.0964917589625805 0.349633285388811 1.27656313687128 0.244444444444444 22.2 22 2 palatal shelves fail to meet at midline 0.111076615429096 0.394614978750671 1.27373261993808 0.24390243902439 22.2 22 2 abnormal long bone metaphysis morphology 0.128275981850113 0.414936937389018 1.27029009934366 0.243243243243243 22.2 22 2 abnormal breathing pattern 0.128275981850113 0.414936937389018 1.27029009934366 0.243243243243243 22.2 22 2 abnormal chromosome morphology 0.128275981850113 0.414936937389018 1.27029009934366 0.243243243243243 22.2 22 2 infertility 0.017918324789325 0.120621284178171 1.26897100266729 0.242990654205607 22.2 22 2 increased T cell proliferation 0.017918324789325 0.120621284178171 1.26897100266729 0.242990654205607 22.2 22 2 abnormal action potential 0.0490071418995216 0.230662753973624 1.26827376585264 0.242857142857143 22.2 22 2 lung inflammation 0.00866750168582253 0.0712740841106894 1.26717664321782 0.242647058823529 22.2 22 2 abnormal skeleton physiology 0.14871563211595 0.429861879748913 1.2660130283021 0.242424242424242 22.2 22 2 abnormal T cell subpopulation ratio 0.14871563211595 0.429861879748913 1.2660130283021 0.242424242424242 22.2 22 2 decreased sensitivity to xenobiotic induced morbidity/mortality 0.14871563211595 0.429861879748913 1.2660130283021 0.242424242424242 22.2 22 2 short limbs 0.0331880927511543 0.170922113288812 1.2605560755939 0.241379310344828 22.2 22 2 abnormal parietal bone morphology 0.173247053236544 0.45363373150095 1.2605560755939 0.241379310344828 22.2 22 2 lordosis 0.173247053236544 0.45363373150095 1.2605560755939 0.241379310344828 22.2 22 2 enlarged epididymis 0.173247053236544 0.45363373150095 1.2605560755939 0.241379310344828 22.2 22 2 increased retinal apoptosis 0.173247053236544 0.45363373150095 1.2605560755939 0.241379310344828 22.2 22 2 short tail 0.0376250356944802 0.190586280258131 1.25838644379425 0.240963855421687 22.2 22 2 abnormal chondrocyte morphology 0.0830299417610229 0.317749200200838 1.25722127116111 0.240740740740741 22.2 22 2 polyphagia 0.0830299417610229 0.317749200200838 1.25722127116111 0.240740740740741 22.2 22 2 neurodegeneration 0.0830299417610229 0.317749200200838 1.25722127116111 0.240740740740741 22.2 22 2 abnormal hindlimb morphology 0.095147469846286 0.346275539491787 1.25335289801908 0.24 22.2 22 2 decreased circulating alkaline phosphatase level 0.095147469846286 0.346275539491787 1.25335289801908 0.24 22.2 22 2 decreased respiratory quotient 0.095147469846286 0.346275539491787 1.25335289801908 0.24 22.2 22 2 abnormal nest building behavior 0.203075806058206 0.500586793451713 1.25335289801908 0.24 22.2 22 2 abnormal primitive streak morphology 0.203075806058206 0.500586793451713 1.25335289801908 0.24 22.2 22 2 abnormal energy expenditure 0.203075806058206 0.500586793451713 1.25335289801908 0.24 22.2 22 2 abnormal eye electrophysiology 0.0156290946555083 0.110290419732133 1.25162651661685 0.239669421487603 22.2 22 2 atelectasis 0.055139618432525 0.249058385054933 1.25041075506598 0.23943661971831 22.2 22 2 increased circulating cholesterol level 0.00467786589292539 0.0460839263708986 1.24623157473488 0.238636363636364 22.2 22 2 male infertility 3.51018760184026e-06 0.000150221165064143 1.24587763222572 0.238568588469185 22.2 22 2 decreased litter size 0.000458069191313966 0.00834759790031861 1.2451756252562 0.238434163701068 22.2 22 2 abnormal hair follicle morphology 0.0715625421976854 0.280997353933295 1.2434056527967 0.238095238095238 22.2 22 2 gliosis 0.0715625421976854 0.280997353933295 1.2434056527967 0.238095238095238 22.2 22 2 small ears 0.240002011138633 0.571985808515984 1.2434056527967 0.238095238095238 22.2 22 2 abnormal eye pigmentation 0.240002011138633 0.571985808515984 1.2434056527967 0.238095238095238 22.2 22 2 increased vasoconstriction 0.240002011138633 0.571985808515984 1.2434056527967 0.238095238095238 22.2 22 2 abnormal stapes morphology 0.240002011138633 0.571985808515984 1.2434056527967 0.238095238095238 22.2 22 2 increased keratinocyte proliferation 0.240002011138633 0.571985808515984 1.2434056527967 0.238095238095238 22.2 22 2 complete atrioventricular septal defect 0.240002011138633 0.571985808515984 1.2434056527967 0.238095238095238 22.2 22 2 absent segment of posterior cerebral artery 0.240002011138633 0.571985808515984 1.2434056527967 0.238095238095238 22.2 22 2 increased muscle cell glucose uptake 0.240002011138633 0.571985808515984 1.2434056527967 0.238095238095238 22.2 22 2 abnormal social investigation 0.0478481433231823 0.226278054213718 1.24029713866471 0.2375 22.2 22 2 abnormal posture 0.0478481433231823 0.226278054213718 1.24029713866471 0.2375 22.2 22 2 kinked tail 0.0319544628526154 0.166014921875734 1.22877735099909 0.235294117647059 22.2 22 2 impaired balance 0.0319544628526154 0.166014921875734 1.22877735099909 0.235294117647059 22.2 22 2 abnormal gastrulation 0.107093047202599 0.383300654556066 1.22877735099909 0.235294117647059 22.2 22 2 increased or absent threshold for auditory brainstem response 0.000614953794608719 0.0104773805759533 1.22877735099909 0.235294117647059 22.2 22 2 abnormal retinal photoreceptor morphology 0.168700643495958 0.443128670217735 1.22877735099909 0.235294117647059 22.2 22 2 abnormal oocyte morphology 0.168700643495958 0.443128670217735 1.22877735099909 0.235294117647059 22.2 22 2 abnormal vision 0.168700643495958 0.443128670217735 1.22877735099909 0.235294117647059 22.2 22 2 increased width of hypertrophic chondrocyte zone 0.168700643495958 0.443128670217735 1.22877735099909 0.235294117647059 22.2 22 2 increased susceptibility to weight gain 0.168700643495958 0.443128670217735 1.22877735099909 0.235294117647059 22.2 22 2 increased exploration in new environment 0.0534316091196139 0.247276516623329 1.22498482831082 0.234567901234568 22.2 22 2 impaired coordination 0.000237223188337551 0.00491743900824715 1.22256243665155 0.234104046242775 22.2 22 2 abnormal immune system physiology 0.0215432982310807 0.139192089220294 1.2213452299245 0.233870967741935 22.2 22 2 abnormal heart tube morphology 0.196637660014682 0.485736027096844 1.21853753974077 0.233333333333333 22.2 22 2 abnormal synaptic transmission 0.196637660014682 0.485736027096844 1.21853753974077 0.233333333333333 22.2 22 2 abnormal spatial learning 0.0101471338780515 0.0814225661988806 1.21746958396536 0.233128834355828 22.2 22 2 female infertility 0.0013269915548937 0.0187019348033885 1.21722869168519 0.233082706766917 22.2 22 2 abnormal cranium morphology 0.0208151466500401 0.136904917331426 1.20814489547859 0.23134328358209 22.2 22 2 increased thermal nociceptive threshold 0.0513719113449539 0.238632361289585 1.20514701732603 0.230769230769231 22.2 22 2 decreased monocyte cell number 0.0894069602148408 0.326818241784594 1.20514701732603 0.230769230769231 22.2 22 2 absent corpus luteum 0.11987762389316 0.402498833618199 1.20514701732603 0.230769230769231 22.2 22 2 abnormal skin condition 0.11987762389316 0.402498833618199 1.20514701732603 0.230769230769231 22.2 22 2 abnormal leukocyte migration 0.11987762389316 0.402498833618199 1.20514701732603 0.230769230769231 22.2 22 2 kinked neural tube 0.11987762389316 0.402498833618199 1.20514701732603 0.230769230769231 22.2 22 2 acanthosis 0.163676934862011 0.433187998100889 1.20514701732603 0.230769230769231 22.2 22 2 decreased bone resorption 0.230612930879455 0.554250884601589 1.20514701732603 0.230769230769231 22.2 22 2 abnormal kidney physiology 0.137641554251727 0.429861879748913 1.19677794081683 0.229166666666667 22.2 22 2 dehydration 0.0871986173499082 0.323154640867017 1.19366942668483 0.228571428571429 22.2 22 2 impaired adaptive thermogenesis 0.189824304519459 0.470072630654209 1.19366942668483 0.228571428571429 22.2 22 2 seizures 0.0377116829081907 0.190586280258131 1.19105173057368 0.228070175438596 22.2 22 2 abnormal gametogenesis 0.158443746116782 0.429861879748913 1.18688721403322 0.227272727272727 22.2 22 2 abnormal basisphenoid bone morphology 0.272651770858608 0.59805191540697 1.18688721403322 0.227272727272727 22.2 22 2 intestinal ulcer 0.272651770858608 0.59805191540697 1.18688721403322 0.227272727272727 22.2 22 2 abnormal tail movements 0.272651770858608 0.59805191540697 1.18688721403322 0.227272727272727 22.2 22 2 increased activated T cell number 0.272651770858608 0.59805191540697 1.18688721403322 0.227272727272727 22.2 22 2 testis hypoplasia 0.272651770858608 0.59805191540697 1.18688721403322 0.227272727272727 22.2 22 2 abnormal female reproductive system physiology 0.272651770858608 0.59805191540697 1.18688721403322 0.227272727272727 22.2 22 2 cleft upper lip 0.272651770858608 0.59805191540697 1.18688721403322 0.227272727272727 22.2 22 2 decreased circulating estradiol level 0.272651770858608 0.59805191540697 1.18688721403322 0.227272727272727 22.2 22 2 abnormal sperm midpiece morphology 0.272651770858608 0.59805191540697 1.18688721403322 0.227272727272727 22.2 22 2 decreased IgM level 0.0554951319040863 0.249058385054933 1.18444002390119 0.22680412371134 22.2 22 2 abnormal coat/ hair morphology 0.133488071541288 0.427625985781011 1.18240839435762 0.226415094339623 22.2 22 2 abnormal nose morphology 0.221178853597295 0.532091294316509 1.17922987716849 0.225806451612903 22.2 22 2 abnormal intestine physiology 0.221178853597295 0.532091294316509 1.17922987716849 0.225806451612903 22.2 22 2 anophthalmia 0.0709553964782918 0.280544357712721 1.17355140263958 0.224719101123595 22.2 22 2 abnormal muscle physiology 0.0709553964782918 0.280544357712721 1.17355140263958 0.224719101123595 22.2 22 2 abnormal epidermis stratum corneum morphology 0.153155685274856 0.429861879748913 1.17235390120832 0.224489795918367 22.2 22 2 decreased urine osmolality 0.153155685274856 0.429861879748913 1.17235390120832 0.224489795918367 22.2 22 2 abnormal craniofacial development 0.153155685274856 0.429861879748913 1.17235390120832 0.224489795918367 22.2 22 2 abnormal spermiogenesis 0.129296680771857 0.416074376998697 1.17051635590862 0.224137931034483 22.2 22 2 increased total body fat amount 0.0342724101067634 0.175416913869494 1.16917247949541 0.223880597014925 22.2 22 2 abnormal femur morphology 0.109829972501083 0.391406957874563 1.16917247949541 0.223880597014925 22.2 22 2 maternal effect 0.109829972501083 0.391406957874563 1.16917247949541 0.223880597014925 22.2 22 2 decreased startle reflex 0.0499769090306628 0.234440733535639 1.16051194261026 0.222222222222222 22.2 22 2 abnormal CNS synaptic transmission 0.0670905278567274 0.275758674371201 1.16051194261026 0.222222222222222 22.2 22 2 decreased osteoclast cell number 0.176144313875126 0.455817097767276 1.16051194261026 0.222222222222222 22.2 22 2 abnormal brain commissure morphology 0.259229091912651 0.588619229696687 1.16051194261026 0.222222222222222 22.2 22 2 cryptorchism 0.259229091912651 0.588619229696687 1.16051194261026 0.222222222222222 22.2 22 2 abnormal skin appearance 0.259229091912651 0.588619229696687 1.16051194261026 0.222222222222222 22.2 22 2 hyperactivity 0.00138055619673744 0.0192928850527212 1.15425581353958 0.221024258760108 22.2 22 2 kidney inflammation 0.169516976805991 0.445037973408868 1.14890682318415 0.22 22.2 22 2 small ovary 0.0855086579741548 0.322648377226027 1.14775906412003 0.21978021978022 22.2 22 2 short humerus 0.203152710749549 0.500586793451713 1.14635935794428 0.219512195121951 22.2 22 2 lethality at weaning, incomplete penetrance 0.203152710749549 0.500586793451713 1.14635935794428 0.219512195121951 22.2 22 2 abnormal osteoclast physiology 0.137713318542662 0.429861879748913 1.14237894350697 0.21875 22.2 22 2 decreased eosinophil cell number 0.137713318542662 0.429861879748913 1.14237894350697 0.21875 22.2 22 2 abnormal auditory brainstem response waveform shape 0.246721100227789 0.571985808515984 1.14237894350697 0.21875 22.2 22 2 absent gastric milk in neonates 0.113037821856705 0.396030396997962 1.13819440525237 0.217948717948718 22.2 22 2 abnormal sleep pattern 0.194715960224782 0.48170656495191 1.13528342211873 0.217391304347826 22.2 22 2 abnormal innervation pattern to muscle 0.306145494733144 0.610450435389736 1.13528342211873 0.217391304347826 22.2 22 2 blistering 0.306145494733144 0.610450435389736 1.13528342211873 0.217391304347826 22.2 22 2 abnormal nasal cavity morphology 0.306145494733144 0.610450435389736 1.13528342211873 0.217391304347826 22.2 22 2 increased susceptibility to age related obesity 0.306145494733144 0.610450435389736 1.13528342211873 0.217391304347826 22.2 22 2 abnormal crista ampullaris morphology 0.306145494733144 0.610450435389736 1.13528342211873 0.217391304347826 22.2 22 2 abnormal chondrocyte physiology 0.306145494733144 0.610450435389736 1.13528342211873 0.217391304347826 22.2 22 2 abnormal vertebral artery topology 0.306145494733144 0.610450435389736 1.13528342211873 0.217391304347826 22.2 22 2 abnormal lipid level 0.109207886762246 0.389748376357369 1.13254779941483 0.216867469879518 22.2 22 2 abnormal incisor morphology 0.156917883319515 0.429861879748913 1.131499144045 0.216666666666667 22.2 22 2 abnormal T cell activation 0.12809385949962 0.414936937389018 1.12914675497214 0.216216216216216 22.2 22 2 impaired skeletal muscle contractility 0.235079942580639 0.563625404500567 1.12914675497214 0.216216216216216 22.2 22 2 decreased circulating chloride level 0.235079942580639 0.563625404500567 1.12914675497214 0.216216216216216 22.2 22 2 increased insulin secretion 0.235079942580639 0.563625404500567 1.12914675497214 0.216216216216216 22.2 22 2 abnormal pancreatic beta cell physiology 0.235079942580639 0.563625404500567 1.12914675497214 0.216216216216216 22.2 22 2 teratozoospermia 0.105490876943249 0.377838094163184 1.12754285333155 0.215909090909091 22.2 22 2 abnormal cued conditioning behavior 0.186683557446924 0.462525248156597 1.12637923841584 0.215686274509804 22.2 22 2 short mandible 0.179046215453063 0.45816851731546 1.11906508751703 0.214285714285714 22.2 22 2 enhanced long term potentiation 0.179046215453063 0.45816851731546 1.11906508751703 0.214285714285714 22.2 22 2 abnormal respiration 0.288706461502877 0.59805191540697 1.11906508751703 0.214285714285714 22.2 22 2 abnormal retinal inner nuclear layer morphology 0.288706461502877 0.59805191540697 1.11906508751703 0.214285714285714 22.2 22 2 decreased circulating progesterone level 0.288706461502877 0.59805191540697 1.11906508751703 0.214285714285714 22.2 22 2 decreased inflammatory response 0.119113492247056 0.402498833618199 1.11906508751703 0.214285714285714 22.2 22 2 abnormal spleen white pulp morphology 0.224230409817575 0.539171720078509 1.11906508751703 0.214285714285714 22.2 22 2 increased startle reflex 0.114864793069451 0.402148026404306 1.1148738325076 0.213483146067416 22.2 22 2 increased osteoclast cell number 0.171787360166801 0.450760610142317 1.11294997774918 0.213114754098361 22.2 22 2 abnormal T-helper 1 physiology 0.214096115597516 0.515550907598085 1.11112845569067 0.212765957446809 22.2 22 2 abnormal female meiosis 0.204607100595494 0.50381098136997 1.10471809921553 0.211538461538462 22.2 22 2 abnormal lens morphology 0.0798695995611274 0.307072069410053 1.10157969552458 0.2109375 22.2 22 2 impaired natural killer cell mediated cytotoxicity 0.195701481091323 0.483904010153743 1.0994323666834 0.210526315789474 22.2 22 2 abnormal reproductive system physiology 0.25898547217455 0.588619229696687 1.0994323666834 0.210526315789474 22.2 22 2 abnormal retinal outer nuclear layer morphology 0.25898547217455 0.588619229696687 1.0994323666834 0.210526315789474 22.2 22 2 hyporesponsive to tactile stimuli 0.25898547217455 0.588619229696687 1.0994323666834 0.210526315789474 22.2 22 2 decreased threshold for auditory brainstem response 0.25898547217455 0.588619229696687 1.0994323666834 0.210526315789474 22.2 22 2 abnormal left-right axis patterning 0.246084808230939 0.571985808515984 1.09304031803989 0.209302325581395 22.2 22 2 abnormal locomotor activation 0.135078045718594 0.429861879748913 1.09037111091403 0.208791208791209 22.2 22 2 abnormal urine homeostasis 0.129927860150824 0.417118585424713 1.08797994619711 0.208333333333333 22.2 22 2 abnormal hair shaft morphology 0.234215737004302 0.562637996907969 1.08797994619711 0.208333333333333 22.2 22 2 blindness 0.340176007169354 0.662377939595904 1.08797994619711 0.208333333333333 22.2 22 2 abnormal sensory capabilities/reflexes/nociception 0.340176007169354 0.662377939595904 1.08797994619711 0.208333333333333 22.2 22 2 abnormal gait 0.0179302098800348 0.120621284178171 1.08164219893771 0.207119741100324 22.2 22 2 focal hair loss 0.318826307137572 0.624964884952491 1.08047663622334 0.206896551724138 22.2 22 2 aphagia 0.318826307137572 0.624964884952491 1.08047663622334 0.206896551724138 22.2 22 2 abnormal brown adipose tissue morphology 0.300175551133502 0.602860523231542 1.07518018212421 0.205882352941176 22.2 22 2 decreased cytotoxic T cell cytolysis 0.300175551133502 0.602860523231542 1.07518018212421 0.205882352941176 22.2 22 2 increased circulating alanine transaminase level 0.178319773976818 0.457981708183733 1.0712417931787 0.205128205128205 22.2 22 2 abnormal iris morphology 0.283581223739077 0.59805191540697 1.0712417931787 0.205128205128205 22.2 22 2 increased autoantibody level 0.283581223739077 0.59805191540697 1.0712417931787 0.205128205128205 22.2 22 2 decreased trabecular bone volume 0.283581223739077 0.59805191540697 1.0712417931787 0.205128205128205 22.2 22 2 short femur 0.163859634036769 0.433187998100889 1.06819849262989 0.204545454545455 22.2 22 2 abnormal cochlea morphology 0.242503679526971 0.571985808515984 1.0638026140594 0.203703703703704 22.2 22 2 abnormal mandible morphology 0.242503679526971 0.571985808515984 1.0638026140594 0.203703703703704 22.2 22 2 axon degeneration 0.242503679526971 0.571985808515984 1.0638026140594 0.203703703703704 22.2 22 2 deafness 0.162063224202821 0.43300995725512 1.05501085691841 0.202020202020202 22.2 22 2 abnormal neuron morphology 0.162063224202821 0.43300995725512 1.05501085691841 0.202020202020202 22.2 22 2 abnormal eye physiology 0.249480376693869 0.573021640836563 1.04446074834923 0.2 22.2 22 2 irregular heartbeat 0.291740273213729 0.59805191540697 1.04446074834923 0.2 22.2 22 2 abnormal metabolism 0.291740273213729 0.59805191540697 1.04446074834923 0.2 22.2 22 2 abnormal pancreatic beta cell morphology 0.30874130843697 0.615133363826163 1.04446074834923 0.2 22.2 22 2 impaired behavioral response to xenobiotic 0.327763362787014 0.639209223781024 1.04446074834923 0.2 22.2 22 2 abnormal hair cycle 0.349373468918295 0.675790438518086 1.04446074834923 0.2 22.2 22 2 salivary gland inflammation 0.349373468918295 0.675790438518086 1.04446074834923 0.2 22.2 22 2 disorganized myocardium 0.349373468918295 0.675790438518086 1.04446074834923 0.2 22.2 22 2 abnormal thyroid gland morphology 0.374451057447141 0.706850136102007 1.04446074834923 0.2 22.2 22 2 increased pre-B cell number 0.374451057447141 0.706850136102007 1.04446074834923 0.2 22.2 22 2 increased cellular sensitivity to ionizing radiation 0.374451057447141 0.706850136102007 1.04446074834923 0.2 22.2 22 2 abnormal preimplantation embryo development 0.374451057447141 0.706850136102007 1.04446074834923 0.2 22.2 22 2 abnormal joint morphology 0.26235424755275 0.595172084621492 1.04446074834923 0.2 22.2 22 2 increased susceptibility to pharmacologically induced seizures 0.193835305834923 0.47976649081032 1.03358094888726 0.197916666666667 22.2 22 2 impaired swimming 0.255421163349453 0.581831633545572 1.02863558549545 0.196969696969697 22.2 22 2 abnormal maternal nurturing 0.268507237884171 0.59805191540697 1.02733844099924 0.19672131147541 22.2 22 2 increased lung adenocarcinoma incidence 0.298246250771351 0.602860523231542 1.02398112583258 0.196078431372549 22.2 22 2 abnormal forelimb morphology 0.315340781778607 0.618620027345651 1.02175507990686 0.195652173913043 22.2 22 2 scaly skin 0.334338544239982 0.651521448332907 1.01898609595047 0.195121951219512 22.2 22 2 abnormal cholesterol homeostasis 0.334338544239982 0.651521448332907 1.01898609595047 0.195121951219512 22.2 22 2 abnormal digit morphology 0.260528075800261 0.591298894665283 1.01544794978397 0.194444444444444 22.2 22 2 short radius 0.355709334487256 0.68751124284153 1.01544794978397 0.194444444444444 22.2 22 2 head tilt 0.355709334487256 0.68751124284153 1.01544794978397 0.194444444444444 22.2 22 2 increased eosinophil cell number 0.287990939276445 0.59805191540697 1.01076846614442 0.193548387096774 22.2 22 2 osteopetrosis 0.380140176595335 0.712315396821766 1.01076846614442 0.193548387096774 22.2 22 2 abnormal postnatal growth/weight/body size 0.380140176595335 0.712315396821766 1.01076846614442 0.193548387096774 22.2 22 2 small cranium 0.380140176595335 0.712315396821766 1.01076846614442 0.193548387096774 22.2 22 2 decreased susceptibility to bacterial infection induced morbidity/mortality 0.380140176595335 0.712315396821766 1.01076846614442 0.193548387096774 22.2 22 2 abnormal excitatory postsynaptic currents 0.264952995950065 0.59805191540697 1.00428918110503 0.192307692307692 22.2 22 2 abnormal leukocyte cell number 0.408698230439448 0.713128007423206 1.00428918110503 0.192307692307692 22.2 22 2 abnormal Schwann cell morphology 0.408698230439448 0.713128007423206 1.00428918110503 0.192307692307692 22.2 22 2 small seminal vesicle 0.408698230439448 0.713128007423206 1.00428918110503 0.192307692307692 22.2 22 2 decreased susceptibility to injury 0.29242041800745 0.59805191540697 0.998381597686763 0.191176470588235 22.2 22 2 increased circulating aspartate transaminase level 0.307871791999445 0.613646700800175 0.994724522237362 0.19047619047619 22.2 22 2 abnormal nervous system electrophysiology 0.268812486569446 0.59805191540697 0.994724522237361 0.19047619047619 22.2 22 2 decreased food intake 0.281995929404891 0.59805191540697 0.991576659825218 0.189873417721519 22.2 22 2 abnormal humerus morphology 0.3838561925988 0.713128007423206 0.988003410600623 0.189189189189189 22.2 22 2 hyperkeratosis 0.311485039159659 0.615165287280652 0.983912299169564 0.188405797101449 22.2 22 2 circling 0.285315811122155 0.59805191540697 0.983021880799275 0.188235294117647 22.2 22 2 abnormal vertebral body morphology 0.410929194218615 0.716067510065713 0.979181951577403 0.1875 22.2 22 2 increased dopamine level 0.410929194218615 0.716067510065713 0.979181951577403 0.1875 22.2 22 2 abnormal long term potentiation 0.410929194218615 0.716067510065713 0.979181951577403 0.1875 22.2 22 2 abnormal intestinal mucosa morphology 0.386340405110375 0.713128007423206 0.971591393813237 0.186046511627907 22.2 22 2 rectal prolapse 0.442668489195537 0.7555965232971 0.967093285508546 0.185185185185185 22.2 22 2 decreased susceptibility to pharmacologically induced seizures 0.442668489195537 0.7555965232971 0.967093285508546 0.185185185185185 22.2 22 2 abnormal motor capabilities/coordination/movement 0.287254180955919 0.59805191540697 0.949509771226572 0.181818181818182 22.2 22 2 abnormal tail morphology 0.369280844656908 0.706850136102007 0.949509771226572 0.181818181818182 22.2 22 2 cochlear hair cell degeneration 0.412500254835791 0.718301983832012 0.949509771226572 0.181818181818182 22.2 22 2 abnormal amino acid level 0.412500254835791 0.718301983832012 0.949509771226572 0.181818181818182 22.2 22 2 dilated heart atrium 0.441556306756894 0.7555965232971 0.949509771226572 0.181818181818182 22.2 22 2 abnormal inflammatory response 0.370297390680933 0.706850136102007 0.942915953370832 0.180555555555556 22.2 22 2 abnormal lens fiber morphology 0.440155965702007 0.754834860174934 0.93733656903136 0.179487179487179 22.2 22 2 abnormal jaw morphology 0.476138495215682 0.807266648655514 0.932554239597526 0.178571428571429 22.2 22 2 arrest of spermatogenesis 0.371529518547311 0.706850136102007 0.932554239597526 0.178571428571429 22.2 22 2 abnormal circulating amino acid level 0.43534429290221 0.750155327114907 0.916193638902833 0.175438596491228 22.2 22 2 cochlear ganglion degeneration 0.458393470860665 0.781263281100311 0.900397196852784 0.172413793103448 22.2 22 2 abnormal microglial cell morphology 0.508911867731953 0.814619221996933 0.900397196852784 0.172413793103448 22.2 22 2 decreased retinal photoreceptor cell number 0.508911867731953 0.814619221996933 0.900397196852784 0.172413793103448 22.2 22 2 stomach inflammation 0.508911867731953 0.814619221996933 0.900397196852784 0.172413793103448 22.2 22 2 abnormal innervation 0.490252765933786 0.807266648655514 0.888902764552536 0.170212765957447 22.2 22 2 syndactyly 0.481292055793169 0.807266648655514 0.885136227414601 0.169491525423729 22.2 22 2 cochlear outer hair cell degeneration 0.494517311232889 0.807266648655514 0.870383956957691 0.166666666666667 22.2 22 2 oligodactyly 0.515588406880469 0.824775666955092 0.870383956957691 0.166666666666667 22.2 22 2 arrested T cell differentiation 0.540819547494685 0.860984719611539 0.870383956957691 0.166666666666667 22.2 22 2 abnormal cellular respiration 0.540819547494685 0.860984719611539 0.870383956957691 0.166666666666667 22.2 22 2 abnormal optic nerve morphology 0.522618993393563 0.834144848294186 0.870383956957691 0.166666666666667 22.2 22 2 astrocytosis 0.515027050150737 0.824142674332555 0.858460889054161 0.164383561643836 22.2 22 2 abnormal vocalization 0.559305819558605 0.883067741131089 0.846860066229105 0.162162162162162 22.2 22 2 autoimmune response 0.571719426513791 0.897748183837718 0.842307055120346 0.161290322580645 22.2 22 2 abnormal digestive system physiology 0.564859070862116 0.891552626122787 0.835568598679384 0.16 22.2 22 2 impaired righting response 0.573018266265397 0.897748183837718 0.82457427501255 0.157894736842105 22.2 22 2 abnormal crypts of Lieberkuhn morphology 0.601495395457342 0.918771750813717 0.815984959647836 0.15625 22.2 22 2 abnormal autopod morphology 0.600081904809178 0.917175876014027 0.812358359827179 0.155555555555556 22.2 22 2 cardiomyopathy 0.600081904809178 0.917175876014027 0.812358359827179 0.155555555555556 22.2 22 2 abnormal enzyme/coenzyme level 0.600867010696086 0.918093789377465 0.810357477167506 0.155172413793103 22.2 22 2 dextrocardia 0.630055947010993 0.958571356691037 0.79125814268881 0.151515151515152 22.2 22 2 diarrhea 0.630055947010993 0.958571356691037 0.79125814268881 0.151515151515152 22.2 22 2 abnormal long bone epiphyseal plate morphology 0.643288184835335 0.965486663708233 0.783345561261922 0.15 22.2 22 2 neuron degeneration 0.647882795015662 0.965486663708233 0.777789918983469 0.148936170212766 22.2 22 2 abnormal inhibitory postsynaptic currents 0.670707272840428 0.994269571627273 0.767985844374434 0.147058823529412 22.2 22 2 arrested B cell differentiation 0.663927327590251 0.98480574083527 0.764239571962851 0.146341463414634 22.2 22 2 short ulna 0.663927327590251 0.98480574083527 0.764239571962851 0.146341463414634 22.2 22 2 abnormal phalanx morphology 0.670469641770451 0.994213552252755 0.76158596233798 0.145833333333333 22.2 22 2 abnormal food intake 0.6890834033825 1 0.756855614745819 0.144927536231884 22.2 22 2 organ of Corti degeneration 0.692134086555142 1 0.746043391678021 0.142857142857143 22.2 22 2 holoprosencephaly 0.683277257229914 1 0.746043391678021 0.142857142857143 22.2 22 2 abnormal pancreas morphology 0.687478716623032 1 0.746043391678021 0.142857142857143 22.2 22 2 abnormal male reproductive system morphology 0.709915653191854 1 0.728693545359928 0.13953488372093 22.2 22 2 cochlear inner hair cell degeneration 0.73261319469583 1 0.716786788082805 0.137254901960784 22.2 22 2 abnormal calcium ion homeostasis 0.731073404021284 1 0.705716721857588 0.135135135135135 22.2 22 2 head bobbing 0.792562475716175 1 0.652787967718269 0.125 22.2 22 2 increased percent body fat/body weight 0.862308622677876 1 0.602573508663017 0.115384615384615 22.2 22 2 pleural effusion 8.35819658198399e-06 0.000259887674971065 3.31109416698437 1 22.3 22 3 vascular inflammation 0.000670870149933993 0.0108012265240182 3.31109416698437 1 22.3 22 3 pale lung 0.000670870149933993 0.0108012265240182 3.31109416698437 1 22.3 22 3 increased neuronal precursor cell number 5.97257663292638e-05 0.00142170185400999 2.94319481509722 0.888888888888889 22.3 22 3 abnormal exoccipital bone morphology 0.000229953527992407 0.00428326590883711 2.89720739611132 0.875 22.3 22 3 delayed intramembranous bone ossification 3.61423441282549e-07 1.87300168789654e-05 2.86961494471979 0.866666666666667 22.3 22 3 abnormal conotruncal ridge morphology 0.000872426396998672 0.0132731538992917 2.83808071455803 0.857142857142857 22.3 22 3 bowed humerus 0.00324752656028367 0.0353772944844567 2.75924513915364 0.833333333333333 22.3 22 3 abnormal aorta tunica adventitia morphology 0.00324752656028367 0.0353772944844567 2.75924513915364 0.833333333333333 22.3 22 3 abnormal olfactory bulb layer morphology 0.00324752656028367 0.0353772944844567 2.75924513915364 0.833333333333333 22.3 22 3 kidney microaneurysm 0.00324752656028367 0.0353772944844567 2.75924513915364 0.833333333333333 22.3 22 3 thymus cortex atrophy 0.00324752656028367 0.0353772944844567 2.75924513915364 0.833333333333333 22.3 22 3 abnormal vertebral artery origin 0.00324752656028367 0.0353772944844567 2.75924513915364 0.833333333333333 22.3 22 3 abnormal dorsal-ventral polarity of the somites 6.67826741588559e-05 0.00156718775443542 2.70907704571448 0.818181818181818 22.3 22 3 osteosclerosis 0.00023730170558565 0.00437250364921707 2.6488753335875 0.8 22.3 22 3 abnormal left subclavian artery morphology 0.00023730170558565 0.00437250364921707 2.6488753335875 0.8 22.3 22 3 abnormal telomere morphology 0.000825750693813409 0.0129185839676783 2.57529546321007 0.777777777777778 22.3 22 3 abnormal ductus venosus valve topology 0.000825750693813409 0.0129185839676783 2.57529546321007 0.777777777777778 22.3 22 3 abnormal eyelid aperture 0.00279984500401747 0.0325449273247357 2.48332062523828 0.75 22.3 22 3 accumulation of giant lysosomes in kidney/renal tubule cells 0.00279984500401747 0.0325449273247357 2.48332062523828 0.75 22.3 22 3 abnormal somite size 0.00279984500401747 0.0325449273247357 2.48332062523828 0.75 22.3 22 3 abnormal olfactory bulb mitral cell layer morphology 0.00279984500401747 0.0325449273247357 2.48332062523828 0.75 22.3 22 3 abnormal cerebellum deep nucleus morphology 0.00279984500401747 0.0325449273247357 2.48332062523828 0.75 22.3 22 3 delayed suture closure 0.00279984500401747 0.0325449273247357 2.48332062523828 0.75 22.3 22 3 increased brain apoptosis 0.00279984500401747 0.0325449273247357 2.48332062523828 0.75 22.3 22 3 decreased vascular endothelial cell proliferation 0.00279984500401747 0.0325449273247357 2.48332062523828 0.75 22.3 22 3 abnormal vascular endothelial cell development 0.000211711867157669 0.00409831338174866 2.48332062523828 0.75 22.3 22 3 decreased red blood cell distribution width 0.000211711867157669 0.00409831338174866 2.48332062523828 0.75 22.3 22 3 abnormal colon goblet cell morphology 0.000211711867157669 0.00409831338174866 2.48332062523828 0.75 22.3 22 3 embryonic lethality before implantation, incomplete penetrance 1.18966069541387e-06 4.93213496640332e-05 2.40806848507954 0.727272727272727 22.3 22 3 decreased trophoblast giant cell number 2.70344508705717e-08 1.81751882542019e-06 2.3976888795404 0.724137931034483 22.3 22 3 testis degeneration 0.000175088392987661 0.00351235788352263 2.36506726213169 0.714285714285714 22.3 22 3 decreased activated T cell number 0.00918527696849618 0.0747901029758895 2.36506726213169 0.714285714285714 22.3 22 3 abnormal hypersensitivity reaction 0.00918527696849618 0.0747901029758895 2.36506726213169 0.714285714285714 22.3 22 3 absent popliteal lymph nodes 0.00918527696849618 0.0747901029758895 2.36506726213169 0.714285714285714 22.3 22 3 abnormal sperm annulus morphology 0.00918527696849618 0.0747901029758895 2.36506726213169 0.714285714285714 22.3 22 3 decreased brain cholesterol level 0.00918527696849618 0.0747901029758895 2.36506726213169 0.714285714285714 22.3 22 3 heart right ventricle outflow tract stenosis 0.00918527696849618 0.0747901029758895 2.36506726213169 0.714285714285714 22.3 22 3 increased right ventricle systolic pressure 0.00918527696849618 0.0747901029758895 2.36506726213169 0.714285714285714 22.3 22 3 ductus venosus stenosis 0.00918527696849618 0.0747901029758895 2.36506726213169 0.714285714285714 22.3 22 3 abnormal Mullerian duct topology 0.00918527696849618 0.0747901029758895 2.36506726213169 0.714285714285714 22.3 22 3 abnormal bone marrow cavity morphology 4.49912639455926e-05 0.00114199764351695 2.33724294140073 0.705882352941177 22.3 22 3 retarded hair growth 0.00219879833301151 0.0273475542668306 2.31776591688906 0.7 22.3 22 3 ketoaciduria 0.00219879833301151 0.0273475542668306 2.31776591688906 0.7 22.3 22 3 fusion of atlas and odontoid process 0.00219879833301151 0.0273475542668306 2.31776591688906 0.7 22.3 22 3 abnormal telomere length 0.000545725962699521 0.00917225224469634 2.29229596175841 0.692307692307692 22.3 22 3 abnormal aorta tunica media morphology 0.000545725962699521 0.00917225224469634 2.29229596175841 0.692307692307692 22.3 22 3 abnormal germ cell morphology 0.00674803362442558 0.0595238781587186 2.20739611132291 0.666666666666667 22.3 22 3 premature neuronal precursor differentiation 0.00674803362442558 0.0595238781587186 2.20739611132291 0.666666666666667 22.3 22 3 short frontal bone 0.00674803362442558 0.0595238781587186 2.20739611132291 0.666666666666667 22.3 22 3 liver hyperplasia 0.00674803362442558 0.0595238781587186 2.20739611132291 0.666666666666667 22.3 22 3 symmetric azygos veins 0.00674803362442558 0.0595238781587186 2.20739611132291 0.666666666666667 22.3 22 3 interstitial pneumonia 0.00165263363385596 0.0215796649040247 2.20739611132291 0.666666666666667 22.3 22 3 pale placenta 0.00165263363385596 0.0215796649040247 2.20739611132291 0.666666666666667 22.3 22 3 persistent right dorsal aorta 0.00165263363385596 0.0215796649040247 2.20739611132291 0.666666666666667 22.3 22 3 incomplete somite formation 2.75091346610232e-08 1.8247725991812e-06 2.17835142564761 0.657894736842105 22.3 22 3 embryonic lethality between implantation and placentation, complete penetrance 1.52782996812102e-09 1.39512938136634e-07 2.15940923933763 0.652173913043478 22.3 22 3 dilated heart 2.09148831158971e-05 0.000594580248580504 2.15940923933763 0.652173913043478 22.3 22 3 vascular smooth muscle hypoplasia 0.00121287358818087 0.0173215960431816 2.12856053591852 0.642857142857143 22.3 22 3 increased pulmonary respiratory rate 0.00121287358818087 0.0173215960431816 2.12856053591852 0.642857142857143 22.3 22 3 decreased compact bone area 0.00121287358818087 0.0173215960431816 2.12856053591852 0.642857142857143 22.3 22 3 abnormal vascular branching morphogenesis 5.95233957163267e-05 0.00142170185400999 2.1070599244446 0.636363636363636 22.3 22 3 abnormal mesenteric lymph node morphology 5.95233957163267e-05 0.00142170185400999 2.1070599244446 0.636363636363636 22.3 22 3 abnormal sphenoid bone morphology 0.00483566195101505 0.0476384518936632 2.1070599244446 0.636363636363636 22.3 22 3 delayed hepatic development 0.00483566195101505 0.0476384518936632 2.1070599244446 0.636363636363636 22.3 22 3 failure of somite differentiation 0.00483566195101505 0.0476384518936632 2.1070599244446 0.636363636363636 22.3 22 3 abnormal bronchiole morphology 0.00483566195101505 0.0476384518936632 2.1070599244446 0.636363636363636 22.3 22 3 pulmonary hypertension 0.00483566195101505 0.0476384518936632 2.1070599244446 0.636363636363636 22.3 22 3 abnormal Bruch membrane morphology 0.00483566195101505 0.0476384518936632 2.1070599244446 0.636363636363636 22.3 22 3 increased number of Howell-Jolly bodies 0.00483566195101505 0.0476384518936632 2.1070599244446 0.636363636363636 22.3 22 3 chylous ascites 0.00483566195101505 0.0476384518936632 2.1070599244446 0.636363636363636 22.3 22 3 abnormal cell adhesion 5.05208892748071e-10 5.46394400309055e-08 2.0847629940272 0.62962962962963 22.3 22 3 abnormal atrial thrombosis 0.0198276635759607 0.124235045705799 2.06943385436523 0.625 22.3 22 3 abnormal umbilical artery morphology 0.0198276635759607 0.124235045705799 2.06943385436523 0.625 22.3 22 3 elevated level of mitotic sister chromatid exchange 0.0198276635759607 0.124235045705799 2.06943385436523 0.625 22.3 22 3 tau protein deposits 0.0198276635759607 0.124235045705799 2.06943385436523 0.625 22.3 22 3 abnormal vertebral body development 0.0198276635759607 0.124235045705799 2.06943385436523 0.625 22.3 22 3 craniofacial phenotype 0.0198276635759607 0.124235045705799 2.06943385436523 0.625 22.3 22 3 enlarged inguinal lymph nodes 0.0198276635759607 0.124235045705799 2.06943385436523 0.625 22.3 22 3 skin fibrosis 0.0198276635759607 0.124235045705799 2.06943385436523 0.625 22.3 22 3 abnormal olfactory bulb glomerular layer morphology 0.0198276635759607 0.124235045705799 2.06943385436523 0.625 22.3 22 3 pulmonary artery hypoplasia 0.0198276635759607 0.124235045705799 2.06943385436523 0.625 22.3 22 3 myocardial trabeculae hypoplasia 0.0198276635759607 0.124235045705799 2.06943385436523 0.625 22.3 22 3 abnormal macrophage activation involved in immune response 0.0198276635759607 0.124235045705799 2.06943385436523 0.625 22.3 22 3 decreased white adipose tissue mass 0.0198276635759607 0.124235045705799 2.06943385436523 0.625 22.3 22 3 abnormal tumor vascularization 0.000165549369601468 0.00333444580472593 2.04972496051413 0.619047619047619 22.3 22 3 enlarged liver sinusoidal spaces 1.69209195155595e-06 6.57668551483661e-05 2.04508757372564 0.617647058823529 22.3 22 3 ventricular hypoplasia 3.19507894042245e-05 0.00085002768602148 2.03759641045192 0.615384615384615 22.3 22 3 abnormal grip strength 0.00342368590770626 0.0367879857253534 2.03759641045192 0.615384615384615 22.3 22 3 abnormal tail bud morphology 0.00342368590770626 0.0367879857253534 2.03759641045192 0.615384615384615 22.3 22 3 absent hypoglossal nerve 0.00342368590770626 0.0367879857253534 2.03759641045192 0.615384615384615 22.3 22 3 abnormal mitral valve morphology 0.00062941434396151 0.0104031108345798 2.02344643537934 0.611111111111111 22.3 22 3 absent inner cell mass 0.00062941434396151 0.0104031108345798 2.02344643537934 0.611111111111111 22.3 22 3 darkened coat color 0.00062941434396151 0.0104031108345798 2.02344643537934 0.611111111111111 22.3 22 3 abnormal pulmonary artery morphology 0.000119581081983662 0.00256429259857207 2.01544862338179 0.608695652173913 22.3 22 3 abnormal hematopoietic stem cell physiology 0.000119581081983662 0.00256429259857207 2.01544862338179 0.608695652173913 22.3 22 3 abnormal basioccipital bone morphology 0.000448765317189385 0.0077640149812952 1.98665650019062 0.6 22.3 22 3 increased cranium width 0.0135718865615467 0.0937779661717985 1.98665650019062 0.6 22.3 22 3 impaired basement membrane formation 0.0135718865615467 0.0937779661717985 1.98665650019062 0.6 22.3 22 3 lymphedema 0.0135718865615467 0.0937779661717985 1.98665650019062 0.6 22.3 22 3 abnormal gas homeostasis 0.0135718865615467 0.0937779661717985 1.98665650019062 0.6 22.3 22 3 abnormal respiratory conducting tube morphology 0.0135718865615467 0.0937779661717985 1.98665650019062 0.6 22.3 22 3 absent inguinal lymph nodes 0.0135718865615467 0.0937779661717985 1.98665650019062 0.6 22.3 22 3 decreased transitional stage T2 B cell number 0.0135718865615467 0.0937779661717985 1.98665650019062 0.6 22.3 22 3 thin ventricle myocardium compact layer 0.0135718865615467 0.0937779661717985 1.98665650019062 0.6 22.3 22 3 abnormal adaptive thermogenesis 0.0135718865615467 0.0937779661717985 1.98665650019062 0.6 22.3 22 3 decreased macrophage cytokine production 0.0135718865615467 0.0937779661717985 1.98665650019062 0.6 22.3 22 3 lethality during fetal growth through weaning, complete penetrance 0.0135718865615467 0.0937779661717985 1.98665650019062 0.6 22.3 22 3 decreased circulating lactate level 0.0135718865615467 0.0937779661717985 1.98665650019062 0.6 22.3 22 3 abnormal fontanelle morphology 0.00240872898488316 0.0295158293098367 1.98665650019062 0.6 22.3 22 3 abnormal lymph node B cell domain morphology 0.00240872898488316 0.0295158293098367 1.98665650019062 0.6 22.3 22 3 abnormal pericyte morphology 0.00240872898488316 0.0295158293098367 1.98665650019062 0.6 22.3 22 3 liver hypoplasia 1.93022998297248e-08 1.35252030497016e-06 1.9739215226253 0.596153846153846 22.3 22 3 increased brain size 0.00168886258269334 0.0219375753234971 1.94770245116728 0.588235294117647 22.3 22 3 abnormal cell differentiation 1.2361901179667e-06 5.04102117777404e-05 1.93820146360061 0.585365853658537 22.3 22 3 absent mesoderm 5.29714634181882e-09 4.1630251579883e-07 1.93147159740755 0.583333333333333 22.3 22 3 abnormal glossopharyngeal nerve morphology 0.00929190159503779 0.074887141634221 1.93147159740755 0.583333333333333 22.3 22 3 abnormal thymus involution 0.00929190159503779 0.074887141634221 1.93147159740755 0.583333333333333 22.3 22 3 decreased left ventricle systolic pressure 0.00929190159503779 0.074887141634221 1.93147159740755 0.583333333333333 22.3 22 3 hematuria 0.00929190159503779 0.074887141634221 1.93147159740755 0.583333333333333 22.3 22 3 abnormal thymus corticomedullary boundary morphology 0.00929190159503779 0.074887141634221 1.93147159740755 0.583333333333333 22.3 22 3 decreased mammary gland epithelial cell proliferation 0.00929190159503779 0.074887141634221 1.93147159740755 0.583333333333333 22.3 22 3 pale kidney 3.12650405542425e-05 0.000836255789018046 1.92257080663609 0.580645161290323 22.3 22 3 decreased neuron apoptosis 4.42489522410682e-06 0.000153943033146374 1.9169492545699 0.578947368421053 22.3 22 3 increased liver cholesterol level 0.00118194069161193 0.0171433088652168 1.9169492545699 0.578947368421053 22.3 22 3 trabecula carnea hypoplasia 6.35212433935053e-07 2.9260943137286e-05 1.91307662981319 0.577777777777778 22.3 22 3 abnormal placenta vasculature 9.21036739924194e-08 5.58799729405228e-06 1.91024663479867 0.576923076923077 22.3 22 3 abnormal vascular development 1.97591541549665e-09 1.69485848139583e-07 1.90638755068797 0.575757575757576 22.3 22 3 pericardial edema 1.41904480988553e-09 1.33202791116614e-07 1.89900988988809 0.573529411764706 22.3 22 3 embryonic lethality between somite formation and embryo turning, complete penetrance 1.01810810572508e-09 9.93154475682795e-08 1.89205380970535 0.571428571428571 22.3 22 3 lymphoid hyperplasia 0.000112618560038894 0.00244662592224234 1.89205380970535 0.571428571428571 22.3 22 3 abnormal spleen periarteriolar lymphoid sheath morphology 0.00637143566707345 0.0574237181950914 1.89205380970535 0.571428571428571 22.3 22 3 amyloid beta deposits 0.00637143566707345 0.0574237181950914 1.89205380970535 0.571428571428571 22.3 22 3 split sternum 0.00637143566707345 0.0574237181950914 1.89205380970535 0.571428571428571 22.3 22 3 sternebra fusion 0.00637143566707345 0.0574237181950914 1.89205380970535 0.571428571428571 22.3 22 3 abnormal vitelline vein topology 0.00637143566707345 0.0574237181950914 1.89205380970535 0.571428571428571 22.3 22 3 abnormal cell morphology 7.88321423677491e-15 1.96094954139776e-12 1.8879045688946 0.570175438596491 22.3 22 3 hydrops fetalis 7.29793411210634e-10 7.40963718525082e-08 1.88548417842165 0.569444444444444 22.3 22 3 abnormal brain vasculature morphology 7.94183747692586e-05 0.00179593824762301 1.87628669462448 0.566666666666667 22.3 22 3 small liver 2.67539680991119e-10 3.02502252938822e-08 1.86779670958093 0.564102564102564 22.3 22 3 abnormal embryonic hematopoiesis 5.59669372542471e-05 0.00135162870310621 1.86249046892871 0.5625 22.3 22 3 increased fibroblast apoptosis 5.59669372542471e-05 0.00135162870310621 1.86249046892871 0.5625 22.3 22 3 abnormal hair follicle orientation 0.00437728583001264 0.044172407716659 1.86249046892871 0.5625 22.3 22 3 abnormal epicardium morphology 0.00437728583001264 0.044172407716659 1.86249046892871 0.5625 22.3 22 3 large intestinal inflammation 0.00437728583001264 0.044172407716659 1.86249046892871 0.5625 22.3 22 3 kidney degeneration 0.00437728583001264 0.044172407716659 1.86249046892871 0.5625 22.3 22 3 impaired somite development 0.00437728583001264 0.044172407716659 1.86249046892871 0.5625 22.3 22 3 increased heart left ventricle size 0.00437728583001264 0.044172407716659 1.86249046892871 0.5625 22.3 22 3 abnormal pulmonary alveolus wall morphology 0.00437728583001264 0.044172407716659 1.86249046892871 0.5625 22.3 22 3 decreased fibroblast apoptosis 0.00437728583001264 0.044172407716659 1.86249046892871 0.5625 22.3 22 3 small heart 8.08679988197111e-07 3.49841994893967e-05 1.86249046892871 0.5625 22.3 22 3 vertebral transformation 8.08679988197111e-07 3.49841994893967e-05 1.86249046892871 0.5625 22.3 22 3 abnormal interventricular septum morphology 5.74159588798494e-07 2.72042281359286e-05 1.85421273351125 0.56 22.3 22 3 spontaneous skin ulceration 0.000403604673370762 0.00717119017864122 1.85421273351125 0.56 22.3 22 3 abnormal primitive streak morphology 0.000403604673370762 0.00717119017864122 1.85421273351125 0.56 22.3 22 3 abnormal egg cylinder morphology 0.000403604673370762 0.00717119017864122 1.85421273351125 0.56 22.3 22 3 abnormal spleen red pulp morphology 3.94212994875347e-05 0.00102681133481929 1.85031732860891 0.558823529411765 22.3 22 3 abnormal bile duct morphology 0.00301317288110814 0.0338386796467562 1.83949675943576 0.555555555555556 22.3 22 3 decreased cellular sensitivity to gamma-irradiation 0.00301317288110814 0.0338386796467562 1.83949675943576 0.555555555555556 22.3 22 3 increased effector memory CD4-positive, alpha-beta T cell number 0.00301317288110814 0.0338386796467562 1.83949675943576 0.555555555555556 22.3 22 3 crypts of Lieberkuhn abscesses 0.0361772010153796 0.197790637758815 1.83949675943576 0.555555555555556 22.3 22 3 abnormal abdominal wall morphology 0.0361772010153796 0.197790637758815 1.83949675943576 0.555555555555556 22.3 22 3 abnormal thymus physiology 0.0361772010153796 0.197790637758815 1.83949675943576 0.555555555555556 22.3 22 3 decreased cellular sensitivity to ionizing radiation 0.0361772010153796 0.197790637758815 1.83949675943576 0.555555555555556 22.3 22 3 abnormal inguinal fat pad morphology 0.0361772010153796 0.197790637758815 1.83949675943576 0.555555555555556 22.3 22 3 absent cervical lymph nodes 0.0361772010153796 0.197790637758815 1.83949675943576 0.555555555555556 22.3 22 3 multiflagellated sperm 0.0361772010153796 0.197790637758815 1.83949675943576 0.555555555555556 22.3 22 3 decreased transitional stage T1 B cell number 0.0361772010153796 0.197790637758815 1.83949675943576 0.555555555555556 22.3 22 3 abnormal incisor color 0.0361772010153796 0.197790637758815 1.83949675943576 0.555555555555556 22.3 22 3 fusion of atlas and occipital bones 0.0361772010153796 0.197790637758815 1.83949675943576 0.555555555555556 22.3 22 3 decreased airway resistance 0.0361772010153796 0.197790637758815 1.83949675943576 0.555555555555556 22.3 22 3 abnormal oxidative phosphorylation 0.0361772010153796 0.197790637758815 1.83949675943576 0.555555555555556 22.3 22 3 increased core body temperature 0.0361772010153796 0.197790637758815 1.83949675943576 0.555555555555556 22.3 22 3 increased cardiac muscle glycogen level 0.0361772010153796 0.197790637758815 1.83949675943576 0.555555555555556 22.3 22 3 pale yolk sac 2.37497238425316e-10 2.8132113361094e-08 1.83506423712387 0.55421686746988 22.3 22 3 pale liver 2.24648817929726e-09 1.89428452406845e-07 1.83452514657242 0.554054054054054 22.3 22 3 increased lymphocyte cell number 1.07698960972036e-08 7.76525117153451e-07 1.82350113544067 0.550724637681159 22.3 22 3 abnormal vascular regression 0.00207804392701728 0.0261067387295731 1.8211017918414 0.55 22.3 22 3 spleen atrophy 0.00207804392701728 0.0261067387295731 1.8211017918414 0.55 22.3 22 3 abnormal induced retinal neovascularization 0.00207804392701728 0.0261067387295731 1.8211017918414 0.55 22.3 22 3 abnormal neuron proliferation 0.00207804392701728 0.0261067387295731 1.8211017918414 0.55 22.3 22 3 small lung 9.91226628158323e-07 4.2148311752886e-05 1.81785562108946 0.549019607843137 22.3 22 3 abnormal germ layer development 0.00143561287915186 0.0194080817222296 1.80605136380966 0.545454545454545 22.3 22 3 abnormal occipital bone morphology 0.00143561287915186 0.0194080817222296 1.80605136380966 0.545454545454545 22.3 22 3 abnormal hemoglobin 0.0240553560941847 0.146840977384747 1.80605136380966 0.545454545454545 22.3 22 3 vasculitis 0.0240553560941847 0.146840977384747 1.80605136380966 0.545454545454545 22.3 22 3 loss of cortex neurons 0.0240553560941847 0.146840977384747 1.80605136380966 0.545454545454545 22.3 22 3 abnormal superovulation 0.0240553560941847 0.146840977384747 1.80605136380966 0.545454545454545 22.3 22 3 aorta dilation 0.0240553560941847 0.146840977384747 1.80605136380966 0.545454545454545 22.3 22 3 abnormal pulmonary alveolar sac morphology 0.0240553560941847 0.146840977384747 1.80605136380966 0.545454545454545 22.3 22 3 thrombocytopenia 3.72110015225942e-16 1.08896901514651e-13 1.80397544270183 0.544827586206897 22.3 22 3 failure to gastrulate 4.79532768517238e-06 0.000163402433107757 1.79950769944803 0.543478260869565 22.3 22 3 increased carcinoma incidence 6.74988911943584e-05 0.00157655860888231 1.79745111922009 0.542857142857143 22.3 22 3 lethality throughout fetal growth and development, complete penetrance 2.15241105993096e-20 9.73476820286956e-18 1.79496157473363 0.542105263157895 22.3 22 3 decreased body height 0.000993363422096731 0.014621251553051 1.79350934044987 0.541666666666667 22.3 22 3 abnormal impulse conducting system conduction 0.000993363422096731 0.014621251553051 1.79350934044987 0.541666666666667 22.3 22 3 abnormal angiogenesis 9.15563694234445e-09 6.90140814972176e-07 1.78978063080236 0.540540540540541 22.3 22 3 abnormal branching of the mammary ductal tree 4.72525210440812e-05 0.00118182141477027 1.78978063080236 0.540540540540541 22.3 22 3 abnormal vitelline vasculature morphology 9.98697985564163e-13 1.91097018391604e-10 1.78511163785244 0.539130434782609 22.3 22 3 kinked neural tube 1.67233885569373e-06 6.55109118667424e-05 1.78289685914543 0.538461538461538 22.3 22 3 decreased circulating glycerol level 0.000688344189408061 0.0110468140074358 1.78289685914543 0.538461538461538 22.3 22 3 absent teeth 0.0161381532302579 0.108349949150517 1.78289685914543 0.538461538461538 22.3 22 3 increased pituitary adenoma incidence 0.0161381532302579 0.108349949150517 1.78289685914543 0.538461538461538 22.3 22 3 increased circulating ammonia level 0.0161381532302579 0.108349949150517 1.78289685914543 0.538461538461538 22.3 22 3 abnormal apoptosis 1.1773143033189e-06 4.92196525967357e-05 1.7781802007879 0.537037037037037 22.3 22 3 abnormal somite shape 0.000477609513718212 0.00813735387242502 1.77380044659877 0.535714285714286 22.3 22 3 abnormal embryonic neuroepithelium morphology 5.83648377219228e-07 2.73929309119402e-05 1.76972274442268 0.53448275862069 22.3 22 3 abnormal cell migration 1.13911251310998e-05 0.000343459681983159 1.76591688905833 0.533333333333333 22.3 22 3 absent egg cylinders 0.0109002433038624 0.0853995439948271 1.76591688905833 0.533333333333333 22.3 22 3 abnormal glial cell morphology 0.0109002433038624 0.0853995439948271 1.76591688905833 0.533333333333333 22.3 22 3 absent chorion 0.0109002433038624 0.0853995439948271 1.76591688905833 0.533333333333333 22.3 22 3 herniated liver 0.0109002433038624 0.0853995439948271 1.76591688905833 0.533333333333333 22.3 22 3 decreased brown adipose tissue mass 0.0109002433038624 0.0853995439948271 1.76591688905833 0.533333333333333 22.3 22 3 abnormal spongiotrophoblast layer morphology 0.000230736736395648 0.00428326590883711 1.75901877621045 0.53125 22.3 22 3 increased incidence of corneal inflammation 0.00740176198324683 0.0643772130535891 1.75293220605055 0.529411764705882 22.3 22 3 abnormal dorsal-ventral axis patterning 0.00740176198324683 0.0643772130535891 1.75293220605055 0.529411764705882 22.3 22 3 abnormal cranial suture morphology 0.00740176198324683 0.0643772130535891 1.75293220605055 0.529411764705882 22.3 22 3 pancytopenia 0.00740176198324683 0.0643772130535891 1.75293220605055 0.529411764705882 22.3 22 3 increased trabecular bone mass 0.00740176198324683 0.0643772130535891 1.75293220605055 0.529411764705882 22.3 22 3 small superior vagus ganglion 0.00504787531388169 0.048668952880933 1.74268114051809 0.526315789473684 22.3 22 3 decreased tumor incidence 0.00504787531388169 0.048668952880933 1.74268114051809 0.526315789473684 22.3 22 3 abnormal nasal septum morphology 0.00504787531388169 0.048668952880933 1.74268114051809 0.526315789473684 22.3 22 3 oliguria 0.00504787531388169 0.048668952880933 1.74268114051809 0.526315789473684 22.3 22 3 abnormal blastocyst morphology 0.00504787531388169 0.048668952880933 1.74268114051809 0.526315789473684 22.3 22 3 Leydig cell hypoplasia 0.00504787531388169 0.048668952880933 1.74268114051809 0.526315789473684 22.3 22 3 increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 0.00504787531388169 0.048668952880933 1.74268114051809 0.526315789473684 22.3 22 3 decreased liver glycogen level 0.00504787531388169 0.048668952880933 1.74268114051809 0.526315789473684 22.3 22 3 increased embryonic tissue cell apoptosis 1.75830073534382e-08 1.24964945119079e-06 1.74044693392768 0.525641025641026 22.3 22 3 abnormal erythropoiesis 8.2240386165238e-11 1.13651644770016e-08 1.73438265889657 0.523809523809524 22.3 22 3 vascular ring 0.00345486700803236 0.0369633620751849 1.73438265889657 0.523809523809524 22.3 22 3 increased muscle cell glucose uptake 0.00345486700803236 0.0369633620751849 1.73438265889657 0.523809523809524 22.3 22 3 decreased blood urea nitrogen level 2.65807943754247e-05 0.000738767888367251 1.73079922365092 0.522727272727273 22.3 22 3 abnormal cell death 1.8586540526657e-05 0.000537604878605339 1.72752739147011 0.521739130434783 22.3 22 3 abnormal chondrocyte physiology 0.00237168148541361 0.0293510333082903 1.72752739147011 0.521739130434783 22.3 22 3 perimembraneous ventricular septal defect 1.64342147156924e-07 9.39772623109997e-06 1.72752739147011 0.521739130434783 22.3 22 3 overriding aortic valve 1.30038604063474e-05 0.000389724129648064 1.72452821197103 0.520833333333333 22.3 22 3 ruffled hair 0.00163226873321654 0.0214829019781807 1.72176896683187 0.52 22.3 22 3 increased cellular sensitivity to ionizing radiation 0.00163226873321654 0.0214829019781807 1.72176896683187 0.52 22.3 22 3 abnormal extraembryonic tissue morphology 2.65957923970868e-10 3.02502252938822e-08 1.72047049853109 0.519607843137255 22.3 22 3 abnormal somite development 2.8366659748536e-08 1.83278093829826e-06 1.7184159600805 0.518987341772152 22.3 22 3 abnormal heart valve morphology 0.00112586092881212 0.0163776553240944 1.71686364214004 0.518518518518518 22.3 22 3 abnormal fetal cardiomyocyte proliferation 0.00112586092881212 0.0163776553240944 1.71686364214004 0.518518518518518 22.3 22 3 abnormal parietal bone morphology 0.000778058821339327 0.012267936671008 1.71263491395743 0.517241379310345 22.3 22 3 abnormal embryonic erythropoiesis 0.000778058821339327 0.012267936671008 1.71263491395743 0.517241379310345 22.3 22 3 embryonic lethality, complete penetrance 4.32713249926546e-28 3.58791403064094e-25 1.7022553084183 0.5141065830721 22.3 22 3 double outlet right ventricle 2.10976395039642e-10 2.56001845200541e-08 1.70196429144056 0.514018691588785 22.3 22 3 increased erythroid progenitor cell number 0.0001801706833427 0.00358539659851973 1.70029159926224 0.513513513513513 22.3 22 3 increased bone trabecula number 8.73098407057454e-05 0.00194783164803176 1.69592628065053 0.51219512195122 22.3 22 3 abnormal myocardial trabeculae morphology 4.24609031308556e-05 0.00108329740038978 1.6923370186809 0.511111111111111 22.3 22 3 atrioventricular septal defect 1.01279493370205e-05 0.000312959925165694 1.68678382091657 0.509433962264151 22.3 22 3 incomplete embryo turning 4.96330566193575e-06 0.000165561129693712 1.68459176916749 0.508771929824561 22.3 22 3 lethality throughout fetal growth and development, incomplete penetrance 7.47148658731978e-16 2.06503587621755e-13 1.68329368265686 0.508379888268156 22.3 22 3 thymus hypoplasia 1.76532271869026e-12 3.13660018767286e-10 1.67954051948482 0.507246376811594 22.3 22 3 embryonic lethality during organogenesis, complete penetrance 1.32924375350223e-44 2.20432922455787e-41 1.66145975164751 0.501785714285714 22.3 22 3 heart inflammation 0.00257619327702501 0.031336336315891 1.65554708349218 0.5 22.3 22 3 decreased bone resorption 0.00257619327702501 0.031336336315891 1.65554708349218 0.5 22.3 22 3 abnormal osteoclast physiology 2.65843909451861e-06 9.86995111584333e-05 1.65554708349218 0.5 22.3 22 3 abnormal trophoblast giant cell morphology 0.000406531978834799 0.00719749677830293 1.65554708349218 0.5 22.3 22 3 abnormal vertebral body morphology 0.000846481473151626 0.0130784016426377 1.65554708349218 0.5 22.3 22 3 abnormal lymphatic vessel morphology 0.000846481473151626 0.0130784016426377 1.65554708349218 0.5 22.3 22 3 abnormal lumbar vertebrae morphology 0.000846481473151626 0.0130784016426377 1.65554708349218 0.5 22.3 22 3 abnormal Peyer's patch T cell area morphology 0.00801770670074611 0.0681847706601913 1.65554708349218 0.5 22.3 22 3 decreased myocardial infarction size 0.00801770670074611 0.0681847706601913 1.65554708349218 0.5 22.3 22 3 absent placental labyrinth 0.00801770670074611 0.0681847706601913 1.65554708349218 0.5 22.3 22 3 abnormal physiological neovascularization 0.00801770670074611 0.0681847706601913 1.65554708349218 0.5 22.3 22 3 abnormal thymocyte activation 0.00801770670074611 0.0681847706601913 1.65554708349218 0.5 22.3 22 3 abnormal sperm mitochondrial sheath morphology 0.00801770670074611 0.0681847706601913 1.65554708349218 0.5 22.3 22 3 increased skin tumor incidence 0.00801770670074611 0.0681847706601913 1.65554708349218 0.5 22.3 22 3 abnormal megakaryocyte differentiation 0.0117903510853855 0.0878098752242411 1.65554708349218 0.5 22.3 22 3 cortical renal glomerulopathies 0.0117903510853855 0.0878098752242411 1.65554708349218 0.5 22.3 22 3 abnormal mammary gland morphology 0.0117903510853855 0.0878098752242411 1.65554708349218 0.5 22.3 22 3 abnormal phrenic nerve morphology 0.0117903510853855 0.0878098752242411 1.65554708349218 0.5 22.3 22 3 absent allantois 0.0117903510853855 0.0878098752242411 1.65554708349218 0.5 22.3 22 3 increased circulating renin level 0.0117903510853855 0.0878098752242411 1.65554708349218 0.5 22.3 22 3 abnormal body wall morphology 0.0117903510853855 0.0878098752242411 1.65554708349218 0.5 22.3 22 3 atrioventricular block 0.0117903510853855 0.0878098752242411 1.65554708349218 0.5 22.3 22 3 abnormal aerobic respiration 0.0117903510853855 0.0878098752242411 1.65554708349218 0.5 22.3 22 3 vasculature congestion 0.0174232007777121 0.114808508435917 1.65554708349218 0.5 22.3 22 3 poor circulation 0.0174232007777121 0.114808508435917 1.65554708349218 0.5 22.3 22 3 impaired muscle relaxation 0.0174232007777121 0.114808508435917 1.65554708349218 0.5 22.3 22 3 decreased creatinine clearance 0.0174232007777121 0.114808508435917 1.65554708349218 0.5 22.3 22 3 fused cornea and lens 0.0587825154692125 0.252744166699294 1.65554708349218 0.5 22.3 22 3 abnormal immune cell physiology 0.0587825154692125 0.252744166699294 1.65554708349218 0.5 22.3 22 3 rhinitis 0.0587825154692125 0.252744166699294 1.65554708349218 0.5 22.3 22 3 delayed dark adaptation 0.0587825154692125 0.252744166699294 1.65554708349218 0.5 22.3 22 3 peritoneal inflammation 0.0587825154692125 0.252744166699294 1.65554708349218 0.5 22.3 22 3 increased left ventricle diastolic pressure 0.0587825154692125 0.252744166699294 1.65554708349218 0.5 22.3 22 3 increased heart rate variability 0.0587825154692125 0.252744166699294 1.65554708349218 0.5 22.3 22 3 ascites 0.0587825154692125 0.252744166699294 1.65554708349218 0.5 22.3 22 3 tachypnea 0.0587825154692125 0.252744166699294 1.65554708349218 0.5 22.3 22 3 absent axillary lymph nodes 0.0587825154692125 0.252744166699294 1.65554708349218 0.5 22.3 22 3 abnormal sperm principal piece morphology 0.0587825154692125 0.252744166699294 1.65554708349218 0.5 22.3 22 3 abnormal cerebellar granule cell migration 0.0587825154692125 0.252744166699294 1.65554708349218 0.5 22.3 22 3 acanthocytosis 0.0587825154692125 0.252744166699294 1.65554708349218 0.5 22.3 22 3 abnormal heart and great artery attachment 0.0587825154692125 0.252744166699294 1.65554708349218 0.5 22.3 22 3 aorta stenosis 0.0587825154692125 0.252744166699294 1.65554708349218 0.5 22.3 22 3 thick aortic valve cusps 0.0587825154692125 0.252744166699294 1.65554708349218 0.5 22.3 22 3 thick aortic valve 0.0587825154692125 0.252744166699294 1.65554708349218 0.5 22.3 22 3 abnormal pulmonary interalveolar septum morphology 0.0587825154692125 0.252744166699294 1.65554708349218 0.5 22.3 22 3 decreased macrophage apoptosis 0.0587825154692125 0.252744166699294 1.65554708349218 0.5 22.3 22 3 ventricular septal defect 8.55867395258743e-12 1.37352912626201e-09 1.65554708349218 0.5 22.3 22 3 decreased circulating alanine transaminase level 1.30748369571784e-06 5.24575111790021e-05 1.65554708349218 0.5 22.3 22 3 lethality, incomplete penetrance 9.51443326236713e-05 0.00209443829558745 1.65554708349218 0.5 22.3 22 3 decreased total retina thickness 0.00028229805347783 0.00518240891532179 1.65554708349218 0.5 22.3 22 3 disorganized myocardium 0.00122433115683243 0.0173215960431816 1.65554708349218 0.5 22.3 22 3 decreased metastatic potential 0.00374999954873048 0.0396941441594343 1.65554708349218 0.5 22.3 22 3 abnormal vasodilation 0.00374999954873048 0.0396941441594343 1.65554708349218 0.5 22.3 22 3 abnormal lung saccule morphology 0.00374999954873048 0.0396941441594343 1.65554708349218 0.5 22.3 22 3 intracerebral hemorrhage 0.00547412113691285 0.0522720780348204 1.65554708349218 0.5 22.3 22 3 increased skin papilloma incidence 0.00547412113691285 0.0522720780348204 1.65554708349218 0.5 22.3 22 3 abnormal basement membrane morphology 0.00547412113691285 0.0522720780348204 1.65554708349218 0.5 22.3 22 3 abnormal blood-brain barrier function 0.00547412113691285 0.0522720780348204 1.65554708349218 0.5 22.3 22 3 increased adenoma incidence 0.00547412113691285 0.0522720780348204 1.65554708349218 0.5 22.3 22 3 abnormal interparietal bone morphology 0.0259048707934423 0.155868508388273 1.65554708349218 0.5 22.3 22 3 megacephaly 0.0259048707934423 0.155868508388273 1.65554708349218 0.5 22.3 22 3 increased hemangioma incidence 0.0259048707934423 0.155868508388273 1.65554708349218 0.5 22.3 22 3 absent olfactory bulb 0.0259048707934423 0.155868508388273 1.65554708349218 0.5 22.3 22 3 multiple persisting craniopharyngeal ducts 0.0259048707934423 0.155868508388273 1.65554708349218 0.5 22.3 22 3 impaired embryo implantation 0.0388188105933316 0.206770431158271 1.65554708349218 0.5 22.3 22 3 myocarditis 0.0388188105933316 0.206770431158271 1.65554708349218 0.5 22.3 22 3 small intestinal inflammation 0.0388188105933316 0.206770431158271 1.65554708349218 0.5 22.3 22 3 abnormal rostral-caudal body axis extension 0.0388188105933316 0.206770431158271 1.65554708349218 0.5 22.3 22 3 bowed ulna 0.0388188105933316 0.206770431158271 1.65554708349218 0.5 22.3 22 3 stria vascularis degeneration 0.0388188105933316 0.206770431158271 1.65554708349218 0.5 22.3 22 3 abnormal cochlear outer hair cell physiology 0.0388188105933316 0.206770431158271 1.65554708349218 0.5 22.3 22 3 decreased prostaglandin level 0.0388188105933316 0.206770431158271 1.65554708349218 0.5 22.3 22 3 increased skeletal muscle glycogen level 0.0388188105933316 0.206770431158271 1.65554708349218 0.5 22.3 22 3 embryonic lethality between implantation and placentation, incomplete penetrance 0.0388188105933316 0.206770431158271 1.65554708349218 0.5 22.3 22 3 decreased erythrocyte cell number 4.01233057921397e-13 7.9845378526358e-11 1.64500219761007 0.496815286624204 22.3 22 3 abnormal placenta labyrinth morphology 3.42146383546703e-07 1.79176658752089e-05 1.63459079129608 0.493670886075949 22.3 22 3 spleen hyperplasia 6.93323478332952e-07 3.16448101349214e-05 1.63347312237896 0.493333333333333 22.3 22 3 rib fusion 2.8571247113773e-06 0.000105290336585941 1.63083742552961 0.492537313432836 22.3 22 3 decreased birth body size 1.32842116447373e-09 1.27094140254939e-07 1.62650239781688 0.491228070175439 22.3 22 3 absent vitelline blood vessels 1.69179723875977e-05 0.000492204167416952 1.62650239781688 0.491228070175439 22.3 22 3 preweaning lethality, complete penetrance 2.62093281368673e-54 1.30391407480915e-50 1.62422592245314 0.490540540540541 22.3 22 3 impaired hematopoiesis 4.94746893042105e-05 0.00121849791726954 1.62308537597273 0.490196078431373 22.3 22 3 decreased circulating creatinine level 7.08377173017207e-05 0.00163915183058633 1.62176040831887 0.489795918367347 22.3 22 3 irregular heartbeat 0.000145537178225495 0.00306799771894846 1.61875714830347 0.488888888888889 22.3 22 3 abnormal ectoderm development 0.000145537178225495 0.00306799771894846 1.61875714830347 0.488888888888889 22.3 22 3 abnormal heart ventricle morphology 7.37697097005714e-07 3.27682415857449e-05 1.61309715827444 0.487179487179487 22.3 22 3 failure of heart looping 0.000431388462401653 0.00755689295932472 1.61309715827444 0.487179487179487 22.3 22 3 decreased IgG level 4.0361053226478e-09 3.34660399669546e-07 1.61080256772213 0.486486486486487 22.3 22 3 embryonic lethality between implantation and somite formation, complete penetrance 3.04265095226156e-18 1.26143237395844e-15 1.60824573824955 0.485714285714286 22.3 22 3 thick pulmonary interalveolar septum 0.000895001896157535 0.01349258297648 1.60824573824955 0.485714285714286 22.3 22 3 ovary cysts 0.000895001896157535 0.01349258297648 1.60824573824955 0.485714285714286 22.3 22 3 enlarged pericardium 0.00129172629095736 0.0180009476120809 1.60537899005303 0.484848484848485 22.3 22 3 dilated heart atrium 0.00129172629095736 0.0180009476120809 1.60537899005303 0.484848484848485 22.3 22 3 abnormal capillary morphology 0.00186719558063755 0.0239414897259582 1.6021423388634 0.483870967741935 22.3 22 3 preaxial polydactyly 0.00186719558063755 0.0239414897259582 1.6021423388634 0.483870967741935 22.3 22 3 decreased embryo size 1.20137810447741e-33 1.19537121395502e-30 1.60013128153429 0.48326359832636 22.3 22 3 blood in lymph vessels 0.00270376229830161 0.0323346572933906 1.59845925302694 0.482758620689655 22.3 22 3 abnormal small intestine morphology 5.20222996164257e-05 0.00127493074183112 1.59423052484433 0.481481481481481 22.3 22 3 rectal prolapse 0.00392293045750841 0.0408296632345279 1.59423052484433 0.481481481481481 22.3 22 3 abnormal eye muscle morphology 0.00392293045750841 0.0408296632345279 1.59423052484433 0.481481481481481 22.3 22 3 hemorrhage 5.45145446981492e-17 1.93721328480923e-14 1.59214315263504 0.480851063829787 22.3 22 3 increased susceptibility to injury 7.43744138462676e-05 0.00169730600406046 1.59187219566556 0.480769230769231 22.3 22 3 diaphragmatic hernia 0.00570482799382027 0.0532006773738508 1.5893252001525 0.48 22.3 22 3 abnormal cochlear outer hair cell morphology 0.00570482799382027 0.0532006773738508 1.5893252001525 0.48 22.3 22 3 thymus atrophy 0.000152290767124513 0.00319682095546182 1.58656595501334 0.479166666666667 22.3 22 3 abnormal myelin sheath morphology 0.000218138931341731 0.00420636117606633 1.58356677551426 0.478260869565217 22.3 22 3 abnormal blood vessel physiology 0.00831802415078712 0.0700048852303762 1.58356677551426 0.478260869565217 22.3 22 3 failure of embryo implantation 0.00831802415078712 0.0700048852303762 1.58356677551426 0.478260869565217 22.3 22 3 conjunctivitis 0.00831802415078712 0.0700048852303762 1.58356677551426 0.478260869565217 22.3 22 3 decreased spleen weight 6.43928508020139e-06 0.000206680279187109 1.58356677551426 0.478260869565217 22.3 22 3 thin ventricular wall 2.82986866594654e-07 1.54709852891033e-05 1.58196721311475 0.477777777777778 22.3 22 3 edema 1.71849439328316e-12 3.13660018767286e-10 1.57854489356232 0.476744186046512 22.3 22 3 liver degeneration 0.0121657427850314 0.088297427348358 1.57671150808779 0.476190476190476 22.3 22 3 embryonic lethality at implantation, complete penetrance 0.0121657427850314 0.088297427348358 1.57671150808779 0.476190476190476 22.3 22 3 abnormal heart morphology 3.37367983732488e-16 1.0490035744182e-13 1.57671150808779 0.476190476190476 22.3 22 3 increased double-negative T cell number 2.65246613402969e-05 0.000738767888367251 1.57412673512372 0.475409836065574 22.3 22 3 anemia 1.07371728687423e-14 2.54368738199966e-12 1.56923894169875 0.4739336492891 22.3 22 3 increased bone marrow cell number 0.000925792843541851 0.0137898784329961 1.56841302646628 0.473684210526316 22.3 22 3 persistence of hyaloid vascular system 0.000925792843541851 0.0137898784329961 1.56841302646628 0.473684210526316 22.3 22 3 unresponsive to tactile stimuli 0.017858579279739 0.116139126688498 1.56841302646628 0.473684210526316 22.3 22 3 absent amnion 0.017858579279739 0.116139126688498 1.56841302646628 0.473684210526316 22.3 22 3 increased circulating VLDL cholesterol level 0.017858579279739 0.116139126688498 1.56841302646628 0.473684210526316 22.3 22 3 embryonic lethality between implantation and somite formation, incomplete penetrance 0.017858579279739 0.116139126688498 1.56841302646628 0.473684210526316 22.3 22 3 increased granulocyte number 4.68969478762294e-06 0.000160905045299477 1.56605805195207 0.472972972972973 22.3 22 3 kidney cysts 4.68969478762294e-06 0.000160905045299477 1.56605805195207 0.472972972972973 22.3 22 3 increased grip strength 4.16415609676863e-07 2.11394658994122e-05 1.56458295802558 0.472527472527473 22.3 22 3 extramedullary hematopoiesis 5.30625914057274e-08 3.34159990181638e-06 1.56183687121904 0.471698113207547 22.3 22 3 embryonic growth arrest 1.44790891831395e-15 3.79123519400626e-13 1.5615640612852 0.471615720524017 22.3 22 3 impaired synaptic plasticity 0.00191886491294296 0.0244778280561313 1.55816196093382 0.470588235294118 22.3 22 3 abnormal direction of heart looping 0.00191886491294296 0.0244778280561313 1.55816196093382 0.470588235294118 22.3 22 3 hyperlipidemia 0.0263311463727923 0.157638331172854 1.55816196093382 0.470588235294118 22.3 22 3 abnormal embryonic-extraembryonic boundary morphology 0.0263311463727923 0.157638331172854 1.55816196093382 0.470588235294118 22.3 22 3 enhanced behavioral response to cocaine 0.0263311463727923 0.157638331172854 1.55816196093382 0.470588235294118 22.3 22 3 delayed heart development 0.0263311463727923 0.157638331172854 1.55816196093382 0.470588235294118 22.3 22 3 abnormal trophoblast layer morphology 0.000156986272403392 0.0032406917228501 1.55816196093382 0.470588235294118 22.3 22 3 failure of chorioallantoic fusion 0.000156986272403392 0.0032406917228501 1.55816196093382 0.470588235294118 22.3 22 3 abnormal respiratory system physiology 0.000224345388121598 0.00427981199151017 1.55418705797225 0.469387755102041 22.3 22 3 abnormal blood vessel morphology 3.20083077935525e-10 3.53869625050941e-08 1.55278898865474 0.468965517241379 22.3 22 3 bradykinesia 0.00276782567547807 0.0325449273247357 1.55207539077392 0.46875 22.3 22 3 abnormal heart development 5.85311459881569e-11 8.56448386150237e-09 1.55076562251167 0.468354430379747 22.3 22 3 abnormal placenta morphology 3.39472002714742e-06 0.000122382116920713 1.55076562251167 0.468354430379747 22.3 22 3 decreased B cell proliferation 3.39472002714742e-06 0.000122382116920713 1.55076562251167 0.468354430379747 22.3 22 3 increased cellular sensitivity to gamma-irradiation 0.000320783983383721 0.00584578870818319 1.54987386539694 0.468085106382979 22.3 22 3 albuminuria 0.000458951397622159 0.00787339035575945 1.54517727792604 0.466666666666667 22.3 22 3 intracranial hemorrhage 5.52877427456154e-05 0.00134831627529136 1.54517727792604 0.466666666666667 22.3 22 3 abnormal cellular respiration 0.00399826454708715 0.041097863887931 1.54517727792604 0.466666666666667 22.3 22 3 abnormal bronchus morphology 0.0390339198468249 0.207029585541528 1.54517727792604 0.466666666666667 22.3 22 3 abnormal placenta size 0.0390339198468249 0.207029585541528 1.54517727792604 0.466666666666667 22.3 22 3 decreased thymocyte apoptosis 0.0390339198468249 0.207029585541528 1.54517727792604 0.466666666666667 22.3 22 3 abnormal aorta wall morphology 0.0390339198468249 0.207029585541528 1.54517727792604 0.466666666666667 22.3 22 3 increased T cell number 1.21805328817127e-06 5.00811166004302e-05 1.54266887325408 0.465909090909091 22.3 22 3 abnormal blood circulation 0.000657051758303703 0.0106647126254669 1.54004379859738 0.465116279069767 22.3 22 3 kidney failure 0.000657051758303703 0.0106647126254669 1.54004379859738 0.465116279069767 22.3 22 3 abnormal double-strand DNA break repair 0.000657051758303703 0.0106647126254669 1.54004379859738 0.465116279069767 22.3 22 3 increased mean corpuscular hemoglobin 3.09437050236499e-07 1.67331448361585e-05 1.53848819880082 0.464646464646465 22.3 22 3 rib bifurcation 0.00578523948929714 0.0532006773738508 1.5372937203856 0.464285714285714 22.3 22 3 small superior cervical ganglion 0.00578523948929714 0.0532006773738508 1.5372937203856 0.464285714285714 22.3 22 3 straub tail 0.00578523948929714 0.0532006773738508 1.5372937203856 0.464285714285714 22.3 22 3 premature aging 0.00578523948929714 0.0532006773738508 1.5372937203856 0.464285714285714 22.3 22 3 hypoxia 0.00578523948929714 0.0532006773738508 1.5372937203856 0.464285714285714 22.3 22 3 abnormal mitotic spindle morphology 0.00578523948929714 0.0532006773738508 1.5372937203856 0.464285714285714 22.3 22 3 prolonged QRS complex duration 0.00578523948929714 0.0532006773738508 1.5372937203856 0.464285714285714 22.3 22 3 abnormal developmental patterning 3.46465137230042e-06 0.000123118861265676 1.53440949201715 0.463414634146341 22.3 22 3 increased inflammatory response 6.19384728580988e-07 2.87984955578544e-05 1.53355940365592 0.463157894736842 22.3 22 3 abnormal neural tube morphology 8.64780147018882e-11 1.16277871119431e-08 1.53291396619647 0.462962962962963 22.3 22 3 decreased tumor growth/size 0.000159809583519522 0.00328534164466787 1.53291396619647 0.462962962962963 22.3 22 3 pallor 1.58184322970889e-11 2.45927189618803e-09 1.53256358586134 0.462857142857143 22.3 22 3 abnormal posture 4.90947839771966e-06 0.000165561129693712 1.53138105223027 0.4625 22.3 22 3 abnormal definitive hematopoiesis 8.76300008261478e-07 3.75826943198349e-05 1.5309360126917 0.462365591397849 22.3 22 3 increased leukocyte cell number 9.41927207908582e-10 9.37217571869039e-08 1.52995385646864 0.462068965517241 22.3 22 3 distended pericardium 0.000227796436880929 0.00427981199151017 1.52819730783894 0.461538461538462 22.3 22 3 abnormal snout morphology 0.000227796436880929 0.00427981199151017 1.52819730783894 0.461538461538462 22.3 22 3 abnormal leukocyte cell number 0.0083865148939305 0.0700048852303762 1.52819730783894 0.461538461538462 22.3 22 3 abnormal Schwann cell morphology 0.0083865148939305 0.0700048852303762 1.52819730783894 0.461538461538462 22.3 22 3 increased leukemia incidence 0.0083865148939305 0.0700048852303762 1.52819730783894 0.461538461538462 22.3 22 3 pulmonary edema 0.0083865148939305 0.0700048852303762 1.52819730783894 0.461538461538462 22.3 22 3 increased thymocyte apoptosis 0.0083865148939305 0.0700048852303762 1.52819730783894 0.461538461538462 22.3 22 3 short premaxilla 0.0582593740473949 0.252744166699294 1.52819730783894 0.461538461538462 22.3 22 3 absent myocardial trabeculae 0.0582593740473949 0.252744166699294 1.52819730783894 0.461538461538462 22.3 22 3 absent trabeculae carneae 0.0582593740473949 0.252744166699294 1.52819730783894 0.461538461538462 22.3 22 3 increased foot pad pigmentation 0.0582593740473949 0.252744166699294 1.52819730783894 0.461538461538462 22.3 22 3 excessive scratching 0.0582593740473949 0.252744166699294 1.52819730783894 0.461538461538462 22.3 22 3 abnormal coping response 0.0582593740473949 0.252744166699294 1.52819730783894 0.461538461538462 22.3 22 3 orthokeratosis 0.0582593740473949 0.252744166699294 1.52819730783894 0.461538461538462 22.3 22 3 empty decidua capsularis 0.0582593740473949 0.252744166699294 1.52819730783894 0.461538461538462 22.3 22 3 increased prostaglandin level 0.0582593740473949 0.252744166699294 1.52819730783894 0.461538461538462 22.3 22 3 increased vascular permeability 0.00134956802737631 0.0184961458297442 1.52819730783894 0.461538461538462 22.3 22 3 abnormal circulating hormone level 0.00134956802737631 0.0184961458297442 1.52819730783894 0.461538461538462 22.3 22 3 decreased circulating HDL cholesterol level 1.02970773313575e-08 7.53352348875049e-07 1.52620746759436 0.4609375 22.3 22 3 abnormal cell cycle 5.67942203821456e-08 3.53189058001468e-06 1.52598252913193 0.460869565217391 22.3 22 3 perinatal lethality, incomplete penetrance 3.60027300031052e-14 8.14152644388402e-12 1.52368935117865 0.460176991150442 22.3 22 3 abnormal embryo size 8.01763900544019e-08 4.92441408050185e-06 1.52368935117865 0.460176991150442 22.3 22 3 increased monocyte cell number 4.44618165192365e-07 2.21197537183202e-05 1.52310331681281 0.46 22.3 22 3 increased B cell derived lymphoma incidence 0.000324823700836345 0.00587754192003874 1.52310331681281 0.46 22.3 22 3 malocclusion 0.00193646717213298 0.0246391922796971 1.52131353618201 0.459459459459459 22.3 22 3 abnormal renal glomerulus morphology 1.59748487936652e-07 9.24126427307956e-06 1.51885053531393 0.458715596330275 22.3 22 3 abnormal primitive streak formation 0.0121832757371428 0.088297427348358 1.5175848265345 0.458333333333333 22.3 22 3 abnormal tumor morphology 0.0121832757371428 0.088297427348358 1.5175848265345 0.458333333333333 22.3 22 3 increased hemangiosarcoma incidence 0.0121832757371428 0.088297427348358 1.5175848265345 0.458333333333333 22.3 22 3 increased body temperature 0.0121832757371428 0.088297427348358 1.5175848265345 0.458333333333333 22.3 22 3 abnormal truncus arteriosus septation 0.0121832757371428 0.088297427348358 1.5175848265345 0.458333333333333 22.3 22 3 spleen hypoplasia 3.18191605229012e-07 1.68404599575993e-05 1.51364304776428 0.457142857142857 22.3 22 3 abnormal liver development 0.00278106534813067 0.0325449273247357 1.51364304776428 0.457142857142857 22.3 22 3 abnormal artery morphology 0.00278106534813067 0.0325449273247357 1.51364304776428 0.457142857142857 22.3 22 3 increased red blood cell distribution width 0.00278106534813067 0.0325449273247357 1.51364304776428 0.457142857142857 22.3 22 3 prenatal lethality, complete penetrance 1.16291037271672e-16 3.85698606951045e-14 1.51262215542092 0.456834532374101 22.3 22 3 embryonic lethality during organogenesis, incomplete penetrance 5.1897970109983e-14 1.12257565781376e-11 1.51158646753634 0.456521739130435 22.3 22 3 abnormal locomotor behavior 1.77139615904768e-06 6.83154720252885e-05 1.51158646753634 0.456521739130435 22.3 22 3 decreased mean corpuscular hemoglobin 3.97884710938158e-05 0.00103097731089445 1.50946939965464 0.455882352941176 22.3 22 3 abnormal platelet physiology 0.0002288301486918 0.00427981199151017 1.50504280317471 0.454545454545455 22.3 22 3 decreased circulating total protein level 0.0002288301486918 0.00427981199151017 1.50504280317471 0.454545454545455 22.3 22 3 osteoporosis 0.000944018699748137 0.0139776578310922 1.50504280317471 0.454545454545455 22.3 22 3 muscular atrophy 0.000944018699748137 0.0139776578310922 1.50504280317471 0.454545454545455 22.3 22 3 increased activated T cell number 0.0177420941584635 0.115988066279048 1.50504280317471 0.454545454545455 22.3 22 3 abnormal chorion morphology 0.0177420941584635 0.115988066279048 1.50504280317471 0.454545454545455 22.3 22 3 increased circulating creatine kinase level 0.0177420941584635 0.115988066279048 1.50504280317471 0.454545454545455 22.3 22 3 increased mammary gland tumor incidence 0.0177420941584635 0.115988066279048 1.50504280317471 0.454545454545455 22.3 22 3 premature suture closure 0.0877218149484025 0.339095593914765 1.50504280317471 0.454545454545455 22.3 22 3 decreased atrioventricular cushion size 0.0877218149484025 0.339095593914765 1.50504280317471 0.454545454545455 22.3 22 3 abnormal stomach epithelium morphology 0.0877218149484025 0.339095593914765 1.50504280317471 0.454545454545455 22.3 22 3 abnormal large intestine morphology 0.0877218149484025 0.339095593914765 1.50504280317471 0.454545454545455 22.3 22 3 abnormal food preference 0.0877218149484025 0.339095593914765 1.50504280317471 0.454545454545455 22.3 22 3 abnormal fear/anxiety-related behavior 0.0877218149484025 0.339095593914765 1.50504280317471 0.454545454545455 22.3 22 3 abnormal vestibular ganglion morphology 0.0877218149484025 0.339095593914765 1.50504280317471 0.454545454545455 22.3 22 3 fatigue 0.0877218149484025 0.339095593914765 1.50504280317471 0.454545454545455 22.3 22 3 retinal detachment 0.0877218149484025 0.339095593914765 1.50504280317471 0.454545454545455 22.3 22 3 abnormal radial glial cell morphology 0.0877218149484025 0.339095593914765 1.50504280317471 0.454545454545455 22.3 22 3 abnormal lymph circulation 0.0877218149484025 0.339095593914765 1.50504280317471 0.454545454545455 22.3 22 3 dilated renal glomerular capsule 0.0877218149484025 0.339095593914765 1.50504280317471 0.454545454545455 22.3 22 3 pathological neovascularization 0.0877218149484025 0.339095593914765 1.50504280317471 0.454545454545455 22.3 22 3 abnormal coronal suture morphology 0.0877218149484025 0.339095593914765 1.50504280317471 0.454545454545455 22.3 22 3 pharyngeal arch hypoplasia 0.0877218149484025 0.339095593914765 1.50504280317471 0.454545454545455 22.3 22 3 increased motor neuron number 0.0877218149484025 0.339095593914765 1.50504280317471 0.454545454545455 22.3 22 3 abnormal palate development 0.0877218149484025 0.339095593914765 1.50504280317471 0.454545454545455 22.3 22 3 abnormal aorta smooth muscle morphology 0.0877218149484025 0.339095593914765 1.50504280317471 0.454545454545455 22.3 22 3 decreased palatine bone horizontal plate size 0.0877218149484025 0.339095593914765 1.50504280317471 0.454545454545455 22.3 22 3 common atrioventricular valve 0.0877218149484025 0.339095593914765 1.50504280317471 0.454545454545455 22.3 22 3 hypolactation 0.0877218149484025 0.339095593914765 1.50504280317471 0.454545454545455 22.3 22 3 thin hypoglossal nerve 0.0877218149484025 0.339095593914765 1.50504280317471 0.454545454545455 22.3 22 3 decreased cell proliferation 2.33594787564611e-11 3.52161838828467e-09 1.50341572987398 0.454054054054054 22.3 22 3 increased oxygen consumption 4.99179285508679e-06 0.000165561129693712 1.50154270363245 0.453488372093023 22.3 22 3 skin edema 0.00134834326070007 0.0184961458297442 1.49787593268341 0.452380952380952 22.3 22 3 preweaning lethality, incomplete penetrance 5.45911135528446e-23 3.39488487406753e-20 1.4976831806653 0.452322738386308 22.3 22 3 prenatal lethality 0.000113339728336091 0.0024515876020524 1.49533284960584 0.451612903225806 22.3 22 3 osteopetrosis 0.00575326251945742 0.0532006773738508 1.49533284960584 0.451612903225806 22.3 22 3 decreased thymus weight 0.00575326251945742 0.0532006773738508 1.49533284960584 0.451612903225806 22.3 22 3 inner cell mass degeneration 0.00575326251945742 0.0532006773738508 1.49533284960584 0.451612903225806 22.3 22 3 abnormal podocyte morphology 0.00575326251945742 0.0532006773738508 1.49533284960584 0.451612903225806 22.3 22 3 abnormal dendritic spine morphology 0.000462690159906269 0.00791025273379273 1.49323854589491 0.450980392156863 22.3 22 3 abnormal lens epithelium morphology 0.0259102022989149 0.155868508388273 1.48999237514297 0.45 22.3 22 3 dilated vasculature 0.0259102022989149 0.155868508388273 1.48999237514297 0.45 22.3 22 3 kidney atrophy 0.0259102022989149 0.155868508388273 1.48999237514297 0.45 22.3 22 3 absent ductus venosus valve 0.0259102022989149 0.155868508388273 1.48999237514297 0.45 22.3 22 3 abnormal liver physiology 1.26141593661072e-06 5.1020685240962e-05 1.48999237514297 0.45 22.3 22 3 abnormal eating behavior 0.000160675683684737 0.00328955360630274 1.48999237514297 0.45 22.3 22 3 decreased rib number 4.98771386593386e-06 0.000165561129693712 1.48813220988062 0.449438202247191 22.3 22 3 abnormal embryonic tissue morphology 5.35544944947239e-09 4.1630251579883e-07 1.48661370762564 0.448979591836735 22.3 22 3 increased sarcoma incidence 0.000658103874576552 0.0106647126254669 1.48661370762563 0.448979591836735 22.3 22 3 abnormal embryo development 2.08788787063967e-08 1.42290988444279e-06 1.48512311901505 0.448529411764706 22.3 22 3 abnormal spermiogenesis 0.00022778505698687 0.00427981199151017 1.48428359209644 0.448275862068966 22.3 22 3 glomerulosclerosis 0.00022778505698687 0.00427981199151017 1.48428359209644 0.448275862068966 22.3 22 3 azoospermia 1.9241407330496e-09 1.67940353454768e-07 1.47853890475403 0.446540880503145 22.3 22 3 heart right ventricle hypertrophy 0.00394027448467815 0.0408393032526538 1.47159740754861 0.444444444444444 22.3 22 3 abnormal pharyngeal arch morphology 0.00394027448467815 0.0408393032526538 1.47159740754861 0.444444444444444 22.3 22 3 abnormal thymus medulla morphology 0.0379637826027177 0.205070378337156 1.47159740754861 0.444444444444444 22.3 22 3 abnormal Peyer's patch follicle morphology 0.0379637826027177 0.205070378337156 1.47159740754861 0.444444444444444 22.3 22 3 abnormal white adipose tissue morphology 0.0379637826027177 0.205070378337156 1.47159740754861 0.444444444444444 22.3 22 3 increased susceptibility to autoimmune disorder 0.0379637826027177 0.205070378337156 1.47159740754861 0.444444444444444 22.3 22 3 decreased lactate dehydrogenase level 0.0379637826027177 0.205070378337156 1.47159740754861 0.444444444444444 22.3 22 3 abnormal pregnancy 0.0379637826027177 0.205070378337156 1.47159740754861 0.444444444444444 22.3 22 3 decreased tumor latency 0.0379637826027177 0.205070378337156 1.47159740754861 0.444444444444444 22.3 22 3 increased effector memory CD8-positive, alpha-beta T cell number 0.0379637826027177 0.205070378337156 1.47159740754861 0.444444444444444 22.3 22 3 abnormal hypoglossal nerve topology 0.0379637826027177 0.205070378337156 1.47159740754861 0.444444444444444 22.3 22 3 decreased platelet aggregation 0.000457798945200213 0.00787339035575945 1.47159740754861 0.444444444444444 22.3 22 3 abnormal atrioventricular cushion morphology 0.0119573824430681 0.088297427348358 1.47159740754861 0.444444444444444 22.3 22 3 abnormal brain commissure morphology 0.0119573824430681 0.088297427348358 1.47159740754861 0.444444444444444 22.3 22 3 abnormal bone trabecula morphology 0.0119573824430681 0.088297427348358 1.47159740754861 0.444444444444444 22.3 22 3 increased osteoclast cell number 0.000224985635408743 0.00427981199151017 1.46556627063243 0.442622950819672 22.3 22 3 lung hemorrhage 0.0056392586929928 0.0531350606015894 1.46077683837546 0.441176470588235 22.3 22 3 abnormal endoderm development 0.0056392586929928 0.0531350606015894 1.46077683837546 0.441176470588235 22.3 22 3 abnormal brown adipose tissue morphology 0.0056392586929928 0.0531350606015894 1.46077683837546 0.441176470588235 22.3 22 3 decreased osteoblast cell number 0.0056392586929928 0.0531350606015894 1.46077683837546 0.441176470588235 22.3 22 3 decreased double-positive T cell number 3.44227717020146e-06 0.000123118861265676 1.45688143347312 0.44 22.3 22 3 abnormal keratinocyte physiology 0.0172734846783248 0.114580781699554 1.45688143347312 0.44 22.3 22 3 abnormal mammary gland development 0.00269795730743866 0.0323346572933906 1.45365109770045 0.439024390243902 22.3 22 3 thick ventricular wall 0.00269795730743866 0.0323346572933906 1.45365109770045 0.439024390243902 22.3 22 3 increased macrophage cell number 0.000449454535600606 0.0077640149812952 1.45223428376507 0.43859649122807 22.3 22 3 decreased hematocrit 2.81222632460112e-08 1.83278093829826e-06 1.45143853895205 0.438356164383562 22.3 22 3 decreased bone marrow cell number 7.7365838363424e-05 0.00175751162492253 1.45143853895205 0.438356164383562 22.3 22 3 scoliosis 0.00807526895366355 0.068557104171461 1.44860369805566 0.4375 22.3 22 3 failure of tooth eruption 0.0558422569005792 0.24716657302525 1.44860369805566 0.4375 22.3 22 3 abnormal olfaction 0.0558422569005792 0.24716657302525 1.44860369805566 0.4375 22.3 22 3 increased intestinal adenocarcinoma incidence 0.0558422569005792 0.24716657302525 1.44860369805566 0.4375 22.3 22 3 abnormal pulmonary elastic fiber morphology 0.0558422569005792 0.24716657302525 1.44860369805566 0.4375 22.3 22 3 bowed tibia 0.0558422569005792 0.24716657302525 1.44860369805566 0.4375 22.3 22 3 bowed radius 0.0558422569005792 0.24716657302525 1.44860369805566 0.4375 22.3 22 3 abnormal amnion morphology 0.0558422569005792 0.24716657302525 1.44860369805566 0.4375 22.3 22 3 blepharitis 0.0558422569005792 0.24716657302525 1.44860369805566 0.4375 22.3 22 3 decreased liver cholesterol level 0.0558422569005792 0.24716657302525 1.44860369805566 0.4375 22.3 22 3 dilated respiratory conducting tubes 0.0558422569005792 0.24716657302525 1.44860369805566 0.4375 22.3 22 3 embryonic lethality between somite formation and embryo turning, incomplete penetrance 0.0558422569005792 0.24716657302525 1.44860369805566 0.4375 22.3 22 3 curly tail 0.00130399064536409 0.0180706224531653 1.44860369805566 0.4375 22.3 22 3 abnormal skeletal muscle fiber morphology 0.000108861275562637 0.00237537213124614 1.44568900248613 0.436619718309859 22.3 22 3 abnormal head morphology 0.000635065110238984 0.0104272241697655 1.44484109104772 0.436363636363636 22.3 22 3 abnormal rostral-caudal axis patterning 0.000635065110238984 0.0104272241697655 1.44484109104772 0.436363636363636 22.3 22 3 increased hepatocyte apoptosis 0.00384036343735817 0.0402227538965408 1.44329745740344 0.435897435897436 22.3 22 3 decreased B-1 B cell number 0.00384036343735817 0.0402227538965408 1.44329745740344 0.435897435897436 22.3 22 3 enlarged heart 5.47629852330448e-12 9.08152838447993e-10 1.44146771924751 0.435344827586207 22.3 22 3 abnormal lung development 2.67362554072412e-05 0.000738960392505694 1.44129981386378 0.435294117647059 22.3 22 3 abnormal axon morphology 2.3670918881584e-06 8.989528353884e-05 1.44093912822468 0.435185185185185 22.3 22 3 abnormal brain morphology 9.77237336557592e-09 7.25635186473734e-07 1.43960615955842 0.434782608695652 22.3 22 3 abnormal allantois morphology 0.00184810228925753 0.0238194530804565 1.43960615955842 0.434782608695652 22.3 22 3 atrial septal defect 0.00184810228925753 0.0238194530804565 1.43960615955842 0.434782608695652 22.3 22 3 abnormal postnatal growth 0.0249913787797529 0.151995243801065 1.43960615955842 0.434782608695652 22.3 22 3 abnormal palatal shelf fusion at midline 0.0249913787797529 0.151995243801065 1.43960615955842 0.434782608695652 22.3 22 3 abnormal sternum morphology 0.000153124941038157 0.00320082597338164 1.43960615955842 0.434782608695652 22.3 22 3 abnormal neural tube closure 3.7492861724142e-05 0.000981720984618981 1.43613722905346 0.433734939759036 22.3 22 3 increased erythrocyte cell number 0.000438349049129308 0.0076251276902738 1.43480747235989 0.433333333333333 22.3 22 3 muscular ventricular septal defect 0.000438349049129308 0.0076251276902738 1.43480747235989 0.433333333333333 22.3 22 3 delayed eyelid opening 0.0115700442410175 0.0878098752242411 1.43480747235989 0.433333333333333 22.3 22 3 abnormal response to new environment 0.0115700442410175 0.0878098752242411 1.43480747235989 0.433333333333333 22.3 22 3 abnormal spleen marginal zone morphology 0.0115700442410175 0.0878098752242411 1.43480747235989 0.433333333333333 22.3 22 3 abnormal microglial cell physiology 0.0115700442410175 0.0878098752242411 1.43480747235989 0.433333333333333 22.3 22 3 abnormal fat pad morphology 0.0115700442410175 0.0878098752242411 1.43480747235989 0.433333333333333 22.3 22 3 decreased hemoglobin content 1.04734757637029e-07 6.27777613547252e-06 1.43245917862444 0.432624113475177 22.3 22 3 abnormal hepatocyte morphology 2.31302375553348e-06 8.85176398752235e-05 1.43182450464189 0.432432432432432 22.3 22 3 abnormal myelopoiesis 0.00261882942036246 0.0316230008890855 1.42979066301598 0.431818181818182 22.3 22 3 increased heart weight 1.46000914573601e-07 8.54534764710192e-06 1.42924928071268 0.431654676258993 22.3 22 3 increased lung adenocarcinoma incidence 0.00126686644006103 0.0177539733501511 1.428315130856 0.431372549019608 22.3 22 3 abnormal gluconeogenesis 0.00126686644006103 0.0177539733501511 1.428315130856 0.431372549019608 22.3 22 3 decreased leukocyte cell number 2.03442808992101e-07 1.15014542583602e-05 1.42594566315385 0.430656934306569 22.3 22 3 hunched posture 7.36321542523023e-05 0.00168811044887191 1.42502786933504 0.430379746835443 22.3 22 3 abnormal nervous system morphology 7.36321542523023e-05 0.00168811044887191 1.42502786933504 0.430379746835443 22.3 22 3 decreased lymphocyte cell number 5.64962877335618e-07 2.70258684110067e-05 1.4227357748761 0.4296875 22.3 22 3 small spleen 2.5347451289755e-05 0.000712449548963452 1.41904035727902 0.428571428571429 22.3 22 3 gliosis 0.00042509083752098 0.00747288663133172 1.41904035727902 0.428571428571429 22.3 22 3 decreased susceptibility to hepatic steatosis 0.00042509083752098 0.00747288663133172 1.41904035727902 0.428571428571429 22.3 22 3 abnormal dermal layer morphology 0.00778290370163941 0.0669895258056333 1.41904035727902 0.428571428571429 22.3 22 3 abnormal embryonic epiblast morphology 0.00778290370163941 0.0669895258056333 1.41904035727902 0.428571428571429 22.3 22 3 left pulmonary isomerism 0.0362185469343277 0.197790637758815 1.41904035727902 0.428571428571429 22.3 22 3 abnormal embryonic/fetal subventricular zone morphology 0.0362185469343277 0.197790637758815 1.41904035727902 0.428571428571429 22.3 22 3 abnormal clavicle morphology 0.0362185469343277 0.197790637758815 1.41904035727902 0.428571428571429 22.3 22 3 abnormal lung morphology 1.57122409533263e-06 6.20384117006335e-05 1.41904035727902 0.428571428571429 22.3 22 3 abnormal ovulation 0.0165864896583963 0.110762128926875 1.41904035727902 0.428571428571429 22.3 22 3 failure of blastocyst to hatch from the zona pellucida 0.0165864896583963 0.110762128926875 1.41904035727902 0.428571428571429 22.3 22 3 abnormal brainstem morphology 0.0165864896583963 0.110762128926875 1.41904035727902 0.428571428571429 22.3 22 3 abnormal renal tubule epithelium morphology 0.0165864896583963 0.110762128926875 1.41904035727902 0.428571428571429 22.3 22 3 midline facial cleft 0.0825252514878589 0.336109828065709 1.41904035727902 0.428571428571429 22.3 22 3 abnormal blood flow velocity 0.0825252514878589 0.336109828065709 1.41904035727902 0.428571428571429 22.3 22 3 abnormal kidney blood vessel morphology 0.0825252514878589 0.336109828065709 1.41904035727902 0.428571428571429 22.3 22 3 increased aggression towards males 0.0825252514878589 0.336109828065709 1.41904035727902 0.428571428571429 22.3 22 3 absent visceral yolk sac blood islands 0.0825252514878589 0.336109828065709 1.41904035727902 0.428571428571429 22.3 22 3 abnormal adrenal gland secretion 0.0825252514878589 0.336109828065709 1.41904035727902 0.428571428571429 22.3 22 3 abnormal fluid regulation 0.0825252514878589 0.336109828065709 1.41904035727902 0.428571428571429 22.3 22 3 increased lactate dehydrogenase level 0.0825252514878589 0.336109828065709 1.41904035727902 0.428571428571429 22.3 22 3 decreased vascular permeability 0.0825252514878589 0.336109828065709 1.41904035727902 0.428571428571429 22.3 22 3 abnormal vascular endothelial cell migration 0.0825252514878589 0.336109828065709 1.41904035727902 0.428571428571429 22.3 22 3 abnormal viscerocranium morphology 0.0825252514878589 0.336109828065709 1.41904035727902 0.428571428571429 22.3 22 3 increased stomach tumor incidence 0.0825252514878589 0.336109828065709 1.41904035727902 0.428571428571429 22.3 22 3 increased lung compliance 0.0825252514878589 0.336109828065709 1.41904035727902 0.428571428571429 22.3 22 3 decreased response to antigen 0.0825252514878589 0.336109828065709 1.41904035727902 0.428571428571429 22.3 22 3 increased neutrophil cell number 1.38274821940721e-07 8.18949094232248e-06 1.41577819553814 0.427586206896552 22.3 22 3 perinatal lethality, complete penetrance 2.01275769624475e-10 2.50336738470441e-08 1.41459891641116 0.427230046948357 22.3 22 3 anophthalmia 3.53990035598739e-05 0.000936755546331769 1.41372559938658 0.426966292134831 22.3 22 3 delayed bone ossification 0.000144313548076078 0.00306799771894846 1.41273351124666 0.426666666666667 22.3 22 3 neurodegeneration 0.00122303027452256 0.0173215960431816 1.41028084890075 0.425925925925926 22.3 22 3 pulmonary hypoplasia 0.00252357611588891 0.0308471527679295 1.40897624126994 0.425531914893617 22.3 22 3 abnormal eye morphology 3.70828215133695e-07 1.90192821679395e-05 1.40542845936747 0.424460431654676 22.3 22 3 decreased brown adipose tissue amount 0.0110796398172699 0.0861268876420591 1.4047066162964 0.424242424242424 22.3 22 3 abnormal T cell subpopulation ratio 0.0110796398172699 0.0861268876420591 1.4047066162964 0.424242424242424 22.3 22 3 myeloid hyperplasia 0.0110796398172699 0.0861268876420591 1.4047066162964 0.424242424242424 22.3 22 3 embryonic lethality before implantation, complete penetrance 1.47493612602958e-06 5.87024578159774e-05 1.40390392680137 0.424 22.3 22 3 no spontaneous movement 0.0237905958535473 0.146301871905312 1.40084753218569 0.423076923076923 22.3 22 3 abnormal Mullerian duct morphology 0.0237905958535473 0.146301871905312 1.40084753218569 0.423076923076923 22.3 22 3 decreased Peyer's patch number 0.0237905958535473 0.146301871905312 1.40084753218569 0.423076923076923 22.3 22 3 abnormal vertebrae morphology 8.19023998725307e-06 0.000256266942997384 1.39734249248882 0.422018348623853 22.3 22 3 abnormal triglyceride level 0.0525857486557932 0.246006611682694 1.39414491241447 0.421052631578947 22.3 22 3 enlarged adrenal glands 0.0525857486557932 0.246006611682694 1.39414491241447 0.421052631578947 22.3 22 3 decreased germ cell number 0.0525857486557932 0.246006611682694 1.39414491241447 0.421052631578947 22.3 22 3 increased susceptibility to ischemic brain injury 0.0525857486557932 0.246006611682694 1.39414491241447 0.421052631578947 22.3 22 3 thin interventricular septum 0.0525857486557932 0.246006611682694 1.39414491241447 0.421052631578947 22.3 22 3 kyphosis 2.40434896875747e-07 1.34400405837847e-05 1.39065955013343 0.42 22.3 22 3 abnormal bone structure 5.22408420086875e-09 4.1630251579883e-07 1.38963019443385 0.419689119170984 22.3 22 3 autoimmune response 0.0157710532621443 0.106604605949957 1.38852336034828 0.419354838709677 22.3 22 3 small cranium 0.0157710532621443 0.106604605949957 1.38852336034828 0.419354838709677 22.3 22 3 abnormal mitochondrial ATP synthesis coupled electron transport 0.0157710532621443 0.106604605949957 1.38852336034828 0.419354838709677 22.3 22 3 abnormal vasculogenesis 0.00501664538501732 0.048668952880933 1.38603941873764 0.418604651162791 22.3 22 3 abnormal homeostasis 0.00501664538501732 0.048668952880933 1.38603941873764 0.418604651162791 22.3 22 3 decreased white adipose tissue amount 0.000550137440343371 0.00921526520440495 1.38374084590392 0.417910447761194 22.3 22 3 abnormal response to infection 0.000186271558413714 0.00367738493296916 1.38311528494284 0.417721518987342 22.3 22 3 abnormal myocardium layer morphology 0.000186271558413714 0.00367738493296916 1.38311528494284 0.417721518987342 22.3 22 3 decreased exploration in new environment 0.000128226164924379 0.00273787626823512 1.37962256957682 0.416666666666667 22.3 22 3 renal hypoplasia 0.0105276388566118 0.0831349258914979 1.37962256957682 0.416666666666667 22.3 22 3 abnormal lysosome morphology 0.0105276388566118 0.0831349258914979 1.37962256957682 0.416666666666667 22.3 22 3 abnormal lymph node morphology 0.00339470859483522 0.0367145114332722 1.37962256957682 0.416666666666667 22.3 22 3 abnormal osteoclast morphology 0.00339470859483522 0.0367145114332722 1.37962256957682 0.416666666666667 22.3 22 3 hemolytic anemia 0.0341400238101888 0.190838897141224 1.37962256957682 0.416666666666667 22.3 22 3 abnormal adipose tissue distribution 0.122652532344882 0.431844549480387 1.37962256957682 0.416666666666667 22.3 22 3 abnormal supraoccipital bone morphology 0.122652532344882 0.431844549480387 1.37962256957682 0.416666666666667 22.3 22 3 amyloidosis 0.122652532344882 0.431844549480387 1.37962256957682 0.416666666666667 22.3 22 3 mesocardia 0.122652532344882 0.431844549480387 1.37962256957682 0.416666666666667 22.3 22 3 abnormal embryonic growth/weight/body size 0.122652532344882 0.431844549480387 1.37962256957682 0.416666666666667 22.3 22 3 abnormal respiratory function 0.122652532344882 0.431844549480387 1.37962256957682 0.416666666666667 22.3 22 3 abnormal AMPA-mediated synaptic currents 0.122652532344882 0.431844549480387 1.37962256957682 0.416666666666667 22.3 22 3 dilated bile duct 0.122652532344882 0.431844549480387 1.37962256957682 0.416666666666667 22.3 22 3 decreased circulating ketone body level 0.122652532344882 0.431844549480387 1.37962256957682 0.416666666666667 22.3 22 3 delayed somite formation 0.122652532344882 0.431844549480387 1.37962256957682 0.416666666666667 22.3 22 3 abnormal nucleotide metabolism 0.122652532344882 0.431844549480387 1.37962256957682 0.416666666666667 22.3 22 3 decreased keratinocyte proliferation 0.122652532344882 0.431844549480387 1.37962256957682 0.416666666666667 22.3 22 3 impaired behavioral response to cocaine 0.122652532344882 0.431844549480387 1.37962256957682 0.416666666666667 22.3 22 3 prenatal growth retardation 0.122652532344882 0.431844549480387 1.37962256957682 0.416666666666667 22.3 22 3 increased spleen weight 1.04795840000867e-05 0.000321826730866861 1.37718075971916 0.415929203539823 22.3 22 3 abnormal muscle physiology 8.83391175326192e-05 0.00196199602555706 1.37652229413957 0.415730337078652 22.3 22 3 increased circulating bilirubin level 0.00230395939258267 0.0285840348581017 1.37441644667276 0.415094339622642 22.3 22 3 lethality at weaning, incomplete penetrance 0.00706585460229764 0.0621071142163088 1.37289270338376 0.414634146341463 22.3 22 3 dermatitis 0.00156761602916315 0.0209647573792652 1.37010793116595 0.413793103448276 22.3 22 3 abnormal spinal nerve morphology 0.0224435837417484 0.139745718542176 1.37010793116595 0.413793103448276 22.3 22 3 increased mortality induced by gamma-irradiation 0.0224435837417484 0.139745718542176 1.37010793116595 0.413793103448276 22.3 22 3 enlarged spleen 5.41024693406178e-12 9.08152838447993e-10 1.36812571483035 0.413194444444444 22.3 22 3 abnormal lymphocyte physiology 0.00476322360118338 0.0476384518936632 1.3676258515805 0.41304347826087 22.3 22 3 decreased B cell number 5.85639111083208e-09 4.48239165790609e-07 1.36622817569743 0.412621359223301 22.3 22 3 kinked tail 4.00918518957928e-05 0.00103345576778015 1.36339171581709 0.411764705882353 22.3 22 3 abnormal gastrulation 0.00322256139877992 0.0353772944844567 1.36339171581709 0.411764705882353 22.3 22 3 overexpanded pulmonary alveoli 0.0148879066042638 0.101462103227688 1.36339171581709 0.411764705882353 22.3 22 3 increased width of hypertrophic chondrocyte zone 0.0148879066042638 0.101462103227688 1.36339171581709 0.411764705882353 22.3 22 3 abnormal vagus nerve morphology 0.0765000342700297 0.319017326482312 1.36339171581709 0.411764705882353 22.3 22 3 abnormal cell cytoskeleton morphology 0.0765000342700297 0.319017326482312 1.36339171581709 0.411764705882353 22.3 22 3 abnormal dendritic cell physiology 2.76665458007976e-05 0.00075626958988444 1.36157143315245 0.411214953271028 22.3 22 3 abnormal seminal vesicle morphology 0.0021867995852482 0.0273475542668306 1.35991367572572 0.410714285714286 22.3 22 3 respiratory failure 7.66569488158636e-07 3.37494088813205e-05 1.35952210829822 0.410596026490066 22.3 22 3 decreased neutrophil cell number 1.31978883637272e-05 0.000390830325056802 1.35839760696795 0.41025641025641 22.3 22 3 increased B cell number 1.31978883637272e-05 0.000390830325056802 1.35839760696795 0.41025641025641 22.3 22 3 abnormal cornea morphology 0.000342424798841754 0.00617233106607871 1.35839760696795 0.41025641025641 22.3 22 3 abnormal male meiosis 0.00148773391769595 0.0200039898392901 1.35700580614113 0.409836065573771 22.3 22 3 insulin resistance 4.36426959232471e-06 0.000152903107195883 1.35453852285724 0.409090909090909 22.3 22 3 abnormal astrocyte morphology 0.00667667182208604 0.0595238781587186 1.35453852285724 0.409090909090909 22.3 22 3 omphalocele 0.00667667182208604 0.0595238781587186 1.35453852285724 0.409090909090909 22.3 22 3 abnormal long bone epiphysis morphology 0.0490099373176182 0.243824438155151 1.35453852285724 0.409090909090909 22.3 22 3 abnormal facial nerve morphology 0.0490099373176182 0.243824438155151 1.35453852285724 0.409090909090909 22.3 22 3 intestinal inflammation 0.0490099373176182 0.243824438155151 1.35453852285724 0.409090909090909 22.3 22 3 abnormal lysosome physiology 0.0490099373176182 0.243824438155151 1.35453852285724 0.409090909090909 22.3 22 3 prolonged PR interval 0.0490099373176182 0.243824438155151 1.35453852285724 0.409090909090909 22.3 22 3 abnormal circulating lipid level 0.0490099373176182 0.243824438155151 1.35453852285724 0.409090909090909 22.3 22 3 abnormal limb posture 0.0490099373176182 0.243824438155151 1.35453852285724 0.409090909090909 22.3 22 3 cleft upper lip 0.0490099373176182 0.243824438155151 1.35453852285724 0.409090909090909 22.3 22 3 decreased susceptibility to viral infection induced morbidity/mortality 0.0490099373176182 0.243824438155151 1.35453852285724 0.409090909090909 22.3 22 3 abnormal sperm midpiece morphology 0.0490099373176182 0.243824438155151 1.35453852285724 0.409090909090909 22.3 22 3 pulmonary vascular congestion 0.0490099373176182 0.243824438155151 1.35453852285724 0.409090909090909 22.3 22 3 increased bone volume 0.0490099373176182 0.243824438155151 1.35453852285724 0.409090909090909 22.3 22 3 impaired humoral immune response 0.0490099373176182 0.243824438155151 1.35453852285724 0.409090909090909 22.3 22 3 neonatal lethality, incomplete penetrance 1.9281969557918e-10 2.45968714232416e-08 1.3499076219244 0.407692307692308 22.3 22 3 increased neuron apoptosis 0.000324889251861438 0.00587754192003874 1.34896429025289 0.407407407407407 22.3 22 3 increased cell proliferation 0.003047098161249 0.0339134526895163 1.34896429025289 0.407407407407407 22.3 22 3 impaired limb coordination 0.003047098161249 0.0339134526895163 1.34896429025289 0.407407407407407 22.3 22 3 abnormal osteoblast physiology 0.003047098161249 0.0339134526895163 1.34896429025289 0.407407407407407 22.3 22 3 axon degeneration 0.003047098161249 0.0339134526895163 1.34896429025289 0.407407407407407 22.3 22 3 decreased circulating fructosamine level 0.0319259300732516 0.181521716702202 1.34896429025289 0.407407407407407 22.3 22 3 decreased bone ossification 0.0319259300732516 0.181521716702202 1.34896429025289 0.407407407407407 22.3 22 3 increased B cell proliferation 0.00206826352211145 0.0261067387295731 1.3468857628411 0.406779661016949 22.3 22 3 decreased caudal vertebrae number 0.00140739884732565 0.01913062640832 1.3451320053374 0.40625 22.3 22 3 failure of primitive streak formation 0.0210365898942627 0.131478686839142 1.3451320053374 0.40625 22.3 22 3 decreased width of hypertrophic chondrocyte zone 0.0139780847919976 0.0960510660776079 1.34233547310177 0.405405405405405 22.3 22 3 skin inflammation 0.0139780847919976 0.0960510660776079 1.34233547310177 0.405405405405405 22.3 22 3 abnormal bone mineralization 1.63843161605033e-05 0.000479482193520612 1.34085631555565 0.40495867768595 22.3 22 3 postnatal lethality, incomplete penetrance 1.71195186223889e-20 8.5169605146385e-18 1.34075996198311 0.404929577464789 22.3 22 3 abnormal muscle morphology 0.00934772159896508 0.074887141634221 1.34020478187463 0.404761904761905 22.3 22 3 abnormal spleen white pulp morphology 0.00934772159896508 0.074887141634221 1.34020478187463 0.404761904761905 22.3 22 3 spina bifida 0.00934772159896508 0.074887141634221 1.34020478187463 0.404761904761905 22.3 22 3 abnormal cytotoxic T cell physiology 0.00934772159896508 0.074887141634221 1.34020478187463 0.404761904761905 22.3 22 3 lung inflammation 5.40557305898512e-06 0.000176925828739809 1.3390454351775 0.404411764705882 22.3 22 3 increased respiratory quotient 0.00628298439477604 0.0571441450895992 1.33852742920645 0.404255319148936 22.3 22 3 abnormal seminiferous tubule morphology 2.58679167787257e-06 9.67615684016244e-05 1.33804490309642 0.404109589041096 22.3 22 3 decreased circulating serum albumin level 9.96931109268936e-05 0.00218490408308941 1.33781582504419 0.404040404040404 22.3 22 3 decreased IgA level 0.0042404395521039 0.0434972923128184 1.33717264435907 0.403846153846154 22.3 22 3 postnatal growth retardation 1.11168853821761e-21 6.14516719736954e-19 1.33634029288421 0.40359477124183 22.3 22 3 internal hemorrhage 0.00132771089649682 0.0183482269724213 1.33432152997878 0.402985074626866 22.3 22 3 reduced fertility 5.11999797900732e-06 0.000168688675136168 1.33396599533183 0.402877697841727 22.3 22 3 decreased circulating glucose level 1.8277521600572e-10 2.39291236744331e-08 1.32918475520519 0.401433691756272 22.3 22 3 abnormal glucose homeostasis 2.56139166368618e-07 1.41588039187097e-05 1.32807623181241 0.401098901098901 22.3 22 3 lethality at weaning, complete penetrance 0.008755018533508 0.0728364836190674 1.32443766679375 0.4 22.3 22 3 abnormal testis morphology 4.21905084303441e-05 0.00108194731670599 1.32443766679375 0.4 22.3 22 3 increased sensitivity to xenobiotic induced morbidity/mortality 6.12248828999943e-05 0.00145044663060701 1.32443766679375 0.4 22.3 22 3 abnormal neurocranium morphology 0.000852909562195685 0.0131369197273174 1.32443766679375 0.4 22.3 22 3 domed cranium 0.00124951236530797 0.0176099830521449 1.32443766679375 0.4 22.3 22 3 abnormal embryo turning 0.00398141011118073 0.0410093484536732 1.32443766679375 0.4 22.3 22 3 abnormal T-helper 2 physiology 0.00398141011118073 0.0410093484536732 1.32443766679375 0.4 22.3 22 3 short stride length 0.00589265597137153 0.0538896387087745 1.32443766679375 0.4 22.3 22 3 decreased circulating alkaline phosphatase level 0.00589265597137153 0.0538896387087745 1.32443766679375 0.4 22.3 22 3 abnormal axon extension 0.00589265597137153 0.0538896387087745 1.32443766679375 0.4 22.3 22 3 decreased circulating phosphate level 0.0130691917957955 0.0922258569986986 1.32443766679375 0.4 22.3 22 3 abnormal intestinal goblet cell morphology 0.0196245752060134 0.124235045705799 1.32443766679375 0.4 22.3 22 3 decreased triglyceride level 0.0196245752060134 0.124235045705799 1.32443766679375 0.4 22.3 22 3 decreased glycogen level 0.0196245752060134 0.124235045705799 1.32443766679375 0.4 22.3 22 3 abnormal hippocampus pyramidal cell morphology 0.0196245752060134 0.124235045705799 1.32443766679375 0.4 22.3 22 3 decreased bone mineralization 0.0196245752060134 0.124235045705799 1.32443766679375 0.4 22.3 22 3 abnormal thyroid gland morphology 0.0453843832314316 0.23006235007312 1.32443766679375 0.4 22.3 22 3 decreased placenta weight 0.0453843832314316 0.23006235007312 1.32443766679375 0.4 22.3 22 3 abnormal preimplantation embryo development 0.0453843832314316 0.23006235007312 1.32443766679375 0.4 22.3 22 3 abnormal heart right ventricle morphology 0.0703694462270452 0.296684741508093 1.32443766679375 0.4 22.3 22 3 abnormal heart electrocardiography waveform feature 0.0703694462270452 0.296684741508093 1.32443766679375 0.4 22.3 22 3 liver inflammation 2.9094425568697e-05 0.000790955012045179 1.32443766679375 0.4 22.3 22 3 salivary gland inflammation 0.0296926100755691 0.169404512759124 1.32443766679375 0.4 22.3 22 3 emphysema 0.0296926100755691 0.169404512759124 1.32443766679375 0.4 22.3 22 3 liver hemorrhage 0.0296926100755691 0.169404512759124 1.32443766679375 0.4 22.3 22 3 abnormal optic cup morphology 0.0296926100755691 0.169404512759124 1.32443766679375 0.4 22.3 22 3 macrocytosis 0.111519472581882 0.402327321316072 1.32443766679375 0.4 22.3 22 3 abnormal prostate gland morphology 0.111519472581882 0.402327321316072 1.32443766679375 0.4 22.3 22 3 abnormal pup retrieval 0.111519472581882 0.402327321316072 1.32443766679375 0.4 22.3 22 3 audiogenic seizures 0.111519472581882 0.402327321316072 1.32443766679375 0.4 22.3 22 3 placental labyrinth hypoplasia 0.111519472581882 0.402327321316072 1.32443766679375 0.4 22.3 22 3 abnormal cricoid cartilage morphology 0.111519472581882 0.402327321316072 1.32443766679375 0.4 22.3 22 3 arthritis 0.111519472581882 0.402327321316072 1.32443766679375 0.4 22.3 22 3 abnormal olfactory nerve morphology 0.111519472581882 0.402327321316072 1.32443766679375 0.4 22.3 22 3 immune system phenotype 0.111519472581882 0.402327321316072 1.32443766679375 0.4 22.3 22 3 abnormal neurotransmitter secretion 0.111519472581882 0.402327321316072 1.32443766679375 0.4 22.3 22 3 abnormal energy homeostasis 0.111519472581882 0.402327321316072 1.32443766679375 0.4 22.3 22 3 abnormal dendritic cell morphology 0.111519472581882 0.402327321316072 1.32443766679375 0.4 22.3 22 3 liver vascular congestion 0.111519472581882 0.402327321316072 1.32443766679375 0.4 22.3 22 3 ostium primum atrial septal defect 0.111519472581882 0.402327321316072 1.32443766679375 0.4 22.3 22 3 bicuspid aortic valve 0.111519472581882 0.402327321316072 1.32443766679375 0.4 22.3 22 3 abnormal coronary vessel morphology 0.111519472581882 0.402327321316072 1.32443766679375 0.4 22.3 22 3 decreased trabecular bone mass 0.111519472581882 0.402327321316072 1.32443766679375 0.4 22.3 22 3 abnormal branching involved in lung morphogenesis 0.111519472581882 0.402327321316072 1.32443766679375 0.4 22.3 22 3 heterochrony 0.111519472581882 0.402327321316072 1.32443766679375 0.4 22.3 22 3 prenatal lethality, incomplete penetrance 6.65547039106414e-11 9.46027577015545e-09 1.3179026125168 0.398026315789474 22.3 22 3 polydactyly 0.000177061285349229 0.00353767025948761 1.31768033175909 0.397959183673469 22.3 22 3 decreased body length 5.92183543353668e-10 6.26832580464787e-08 1.31718709562517 0.397810218978102 22.3 22 3 decreased body weight 4.09046539971277e-40 5.08751634089275e-37 1.31587910351883 0.397415185783522 22.3 22 3 abnormal mesoderm development 0.00551125465678972 0.0525246826665843 1.311942971824 0.39622641509434 22.3 22 3 abnormal cytokine secretion 3.83612638727805e-06 0.000135352686359633 1.31153729990939 0.396103896103896 22.3 22 3 oligodactyly 0.00817530302232347 0.0692881303851095 1.31064144109798 0.395833333333333 22.3 22 3 delayed endochondral bone ossification 0.0121795791234694 0.088297427348358 1.30903722880777 0.395348837209302 22.3 22 3 decreased oxygen consumption 0.0121795791234694 0.088297427348358 1.30903722880777 0.395348837209302 22.3 22 3 abnormal frontal bone morphology 0.0182423107608227 0.118325288181347 1.30701085538857 0.394736842105263 22.3 22 3 abnormal ovary morphology 0.00161194490726154 0.0213282604085803 1.30578361514877 0.394366197183099 22.3 22 3 corneal opacity 0.00161194490726154 0.0213282604085803 1.30578361514877 0.394366197183099 22.3 22 3 increased circulating free fatty acid level 0.00161194490726154 0.0213282604085803 1.30578361514877 0.394366197183099 22.3 22 3 abnormal CD4-positive, alpha-beta T cell physiology 0.00161194490726154 0.0213282604085803 1.30578361514877 0.394366197183099 22.3 22 3 decreased cardiac muscle contractility 0.00015631088228806 0.0032406917228501 1.30533520044576 0.394230769230769 22.3 22 3 abnormal tooth development 0.0275086074443081 0.163898589263991 1.30437042941808 0.393939393939394 22.3 22 3 abnormal skeleton physiology 0.0275086074443081 0.163898589263991 1.30437042941808 0.393939393939394 22.3 22 3 abnormal locomotor coordination 0.0275086074443081 0.163898589263991 1.30437042941808 0.393939393939394 22.3 22 3 decreased circulating cholesterol level 7.34942474806995e-07 3.27682415857449e-05 1.30272557389549 0.39344262295082 22.3 22 3 arrest of spermatogenesis 0.000704238612563714 0.0112655533681816 1.30078699417243 0.392857142857143 22.3 22 3 abnormal circulating cholesterol level 0.0418514503416873 0.213549708153738 1.30078699417243 0.392857142857143 22.3 22 3 abnormal visceral yolk sac morphology 0.00102936013553377 0.015106391369559 1.29929011615842 0.392405063291139 22.3 22 3 abnormal lipid homeostasis 3.10542468843344e-05 0.000835107449997642 1.2989677116631 0.392307692307692 22.3 22 3 microphthalmia 6.65450367620461e-06 0.000212218947366141 1.29846830077818 0.392156862745098 22.3 22 3 abnormal cervical vertebrae morphology 0.00761529763110806 0.0659850017476456 1.29846830077818 0.392156862745098 22.3 22 3 abnormal behavior 1.57102374456017e-09 1.39568627306908e-07 1.29823476331402 0.392086330935252 22.3 22 3 decreased IgM level 0.000310055975281689 0.00567106057730296 1.29712967366398 0.391752577319588 22.3 22 3 abnormal immune system morphology 0.0113211724185738 0.0875938301437083 1.29564554360258 0.391304347826087 22.3 22 3 abnormal B cell morphology 0.0644504392348172 0.274052081361723 1.29564554360258 0.391304347826087 22.3 22 3 abnormal corneal stroma morphology 0.0644504392348172 0.274052081361723 1.29564554360258 0.391304347826087 22.3 22 3 increased susceptibility to fungal infection 0.0644504392348172 0.274052081361723 1.29564554360258 0.391304347826087 22.3 22 3 decreased circulating LDL cholesterol level 0.00324973338279331 0.0353772944844567 1.29339615897827 0.390625 22.3 22 3 abnormal humoral immune response 0.000199485572599805 0.00390724694363791 1.29290343663199 0.39047619047619 22.3 22 3 premature death 5.50628117936171e-26 3.91339269533207e-23 1.29213430906707 0.390243902439024 22.3 22 3 liver fibrosis 0.016911327599634 0.112478415518956 1.29213430906707 0.390243902439024 22.3 22 3 hemopericardium 0.016911327599634 0.112478415518956 1.29213430906707 0.390243902439024 22.3 22 3 abnormal colon morphology 0.00478933872753941 0.0476384518936632 1.29076552272272 0.389830508474576 22.3 22 3 increased circulating alkaline phosphatase level 5.48266525216963e-06 0.000178276206729045 1.28764773160503 0.388888888888889 22.3 22 3 oxidative stress 0.00061526831751045 0.0102716774483708 1.28764773160503 0.388888888888889 22.3 22 3 abnormal maxilla morphology 0.00707935424486113 0.0621160271043812 1.28764773160503 0.388888888888889 22.3 22 3 delayed kidney development 0.101023103512865 0.373117995528213 1.28764773160503 0.388888888888889 22.3 22 3 thick dermal layer 0.101023103512865 0.373117995528213 1.28764773160503 0.388888888888889 22.3 22 3 blepharoptosis 0.101023103512865 0.373117995528213 1.28764773160503 0.388888888888889 22.3 22 3 long tibia 0.101023103512865 0.373117995528213 1.28764773160503 0.388888888888889 22.3 22 3 jerky movement 0.101023103512865 0.373117995528213 1.28764773160503 0.388888888888889 22.3 22 3 decreased pulmonary respiratory rate 0.101023103512865 0.373117995528213 1.28764773160503 0.388888888888889 22.3 22 3 increased gastrointestinal tumor incidence 0.101023103512865 0.373117995528213 1.28764773160503 0.388888888888889 22.3 22 3 decreased fluid intake 0.101023103512865 0.373117995528213 1.28764773160503 0.388888888888889 22.3 22 3 impaired leukocyte tethering or rolling 0.101023103512865 0.373117995528213 1.28764773160503 0.388888888888889 22.3 22 3 increased adipocyte glucose uptake 0.101023103512865 0.373117995528213 1.28764773160503 0.388888888888889 22.3 22 3 abnormal enzyme/coenzyme activity 7.91620659724637e-06 0.00024926030266646 1.28647607761813 0.388535031847134 22.3 22 3 cataract 8.2843419682636e-05 0.0018649140856159 1.2861274863493 0.388429752066116 22.3 22 3 cardiac fibrosis 0.000897697480445199 0.01349258297648 1.2854836177704 0.388235294117647 22.3 22 3 increased circulating LDL cholesterol level 0.0105014092733826 0.0831349258914979 1.28389365658578 0.387755102040816 22.3 22 3 abnormal craniofacial development 0.0105014092733826 0.0831349258914979 1.28389365658578 0.387755102040816 22.3 22 3 small testis 4.58338139368704e-09 3.73808564485131e-07 1.28364882560626 0.38768115942029 22.3 22 3 impaired glucose tolerance 3.01002711878378e-08 1.91985704050632e-06 1.28171387109072 0.387096774193548 22.3 22 3 pericardial effusion 0.00445298348884147 0.0448453296700128 1.28171387109072 0.387096774193548 22.3 22 3 abnormal cranial ganglia morphology 0.0384851722735216 0.206770431158271 1.28171387109072 0.387096774193548 22.3 22 3 abnormal object recognition memory 0.0384851722735216 0.206770431158271 1.28171387109072 0.387096774193548 22.3 22 3 decreased neuronal precursor cell number 0.0384851722735216 0.206770431158271 1.28171387109072 0.387096774193548 22.3 22 3 decreased sensitivity to induced morbidity/mortality 0.0156443726095256 0.106181110139686 1.27928638269851 0.386363636363636 22.3 22 3 abnormal craniofacial bone morphology 0.0065701032849075 0.05878824432089 1.27796616971327 0.385964912280702 22.3 22 3 increased hepatocellular carcinoma incidence 0.0065701032849075 0.05878824432089 1.27796616971327 0.385964912280702 22.3 22 3 decreased susceptibility to induced arthritis 0.0065701032849075 0.05878824432089 1.27796616971327 0.385964912280702 22.3 22 3 short tail 0.00122136084202726 0.0173215960431816 1.2765664258253 0.385542168674699 22.3 22 3 abnormal liver morphology 2.91036653385481e-06 0.00010646377577888 1.27634356157498 0.385474860335196 22.3 22 3 retinal degeneration 0.000535084186665494 0.00905457084578514 1.27615087685856 0.385416666666667 22.3 22 3 abnormal rib morphology 4.66379545136277e-05 0.00117778590713349 1.27538441987546 0.385185185185185 22.3 22 3 decreased T cell proliferation 2.08430797308699e-05 0.000594580248580504 1.27521869944668 0.385135135135135 22.3 22 3 abnormal skin condition 0.00972458393048562 0.0776561878879068 1.27349775653245 0.384615384615385 22.3 22 3 eyelids open at birth 0.00972458393048562 0.0776561878879068 1.27349775653245 0.384615384615385 22.3 22 3 abnormal ureter morphology 0.0588805003426093 0.252744166699294 1.27349775653245 0.384615384615385 22.3 22 3 thick skin 0.0588805003426093 0.252744166699294 1.27349775653245 0.384615384615385 22.3 22 3 abnormal erythrocyte osmotic lysis 0.0588805003426093 0.252744166699294 1.27349775653245 0.384615384615385 22.3 22 3 abnormal nerve conduction 0.0588805003426093 0.252744166699294 1.27349775653245 0.384615384615385 22.3 22 3 abnormal renal/urinary system morphology 0.162898256280811 0.492955489657564 1.27349775653245 0.384615384615385 22.3 22 3 small trigeminal ganglion 0.162898256280811 0.492955489657564 1.27349775653245 0.384615384615385 22.3 22 3 uterus hypoplasia 0.162898256280811 0.492955489657564 1.27349775653245 0.384615384615385 22.3 22 3 abnormal pulmonary alveolus epithelial cell morphology 0.162898256280811 0.492955489657564 1.27349775653245 0.384615384615385 22.3 22 3 dystrophic cardiac calcinosis 0.162898256280811 0.492955489657564 1.27349775653245 0.384615384615385 22.3 22 3 abnormal bile duct development 0.162898256280811 0.492955489657564 1.27349775653245 0.384615384615385 22.3 22 3 axonal dystrophy 0.162898256280811 0.492955489657564 1.27349775653245 0.384615384615385 22.3 22 3 abnormal retinal inner plexiform layer morphology 0.162898256280811 0.492955489657564 1.27349775653245 0.384615384615385 22.3 22 3 abnormal vertebral arch development 0.162898256280811 0.492955489657564 1.27349775653245 0.384615384615385 22.3 22 3 increased circulating thyroxine level 0.162898256280811 0.492955489657564 1.27349775653245 0.384615384615385 22.3 22 3 increased renin activity 0.162898256280811 0.492955489657564 1.27349775653245 0.384615384615385 22.3 22 3 total cataracts 0.162898256280811 0.492955489657564 1.27349775653245 0.384615384615385 22.3 22 3 increased insulin sensitivity 3.01099668232381e-05 0.000814114592095705 1.27349775653245 0.384615384615385 22.3 22 3 abnormal B cell differentiation 0.000779229746339401 0.012267936671008 1.27349775653245 0.384615384615385 22.3 22 3 small lens 0.0234291142538794 0.144794836537951 1.27349775653245 0.384615384615385 22.3 22 3 abnormal lens fiber morphology 0.0234291142538794 0.144794836537951 1.27349775653245 0.384615384615385 22.3 22 3 impaired macrophage chemotaxis 0.0234291142538794 0.144794836537951 1.27349775653245 0.384615384615385 22.3 22 3 abnormal response to injury 0.0234291142538794 0.144794836537951 1.27349775653245 0.384615384615385 22.3 22 3 astrocytosis 0.00261378211545913 0.0316230008890855 1.27000872158305 0.383561643835616 22.3 22 3 decreased bone mineral density 2.01114839044187e-08 1.38964767256226e-06 1.26966768809175 0.383458646616541 22.3 22 3 abnormal cardiovascular system physiology 6.2910346997623e-05 0.00148331268394869 1.26966768809175 0.383458646616541 22.3 22 3 increased exploration in new environment 0.00165864937369853 0.0216015199846863 1.26720887872241 0.382716049382716 22.3 22 3 increased susceptibility to weight gain 0.0353214222500498 0.196779480060468 1.26600659325873 0.382352941176471 22.3 22 3 abnormal skin physiology 0.0353214222500498 0.196779480060468 1.26600659325873 0.382352941176471 22.3 22 3 cleft palate 8.47420320593635e-05 0.00189906130403303 1.26377639961235 0.381679389312977 22.3 22 3 respiratory distress 7.07467406291697e-06 0.000224181550719821 1.26319199434086 0.38150289017341 22.3 22 3 hydronephrosis 0.0015395899063125 0.0206454441614682 1.26136920647024 0.380952380952381 22.3 22 3 trunk curl 0.0913853842533331 0.342351119473142 1.26136920647024 0.380952380952381 22.3 22 3 abnormal erythrocyte physiology 0.0913853842533331 0.342351119473142 1.26136920647024 0.380952380952381 22.3 22 3 absent segment of posterior cerebral artery 0.0913853842533331 0.342351119473142 1.26136920647024 0.380952380952381 22.3 22 3 skin lesions 0.00563631397128155 0.0531350606015894 1.26136920647024 0.380952380952381 22.3 22 3 decreased bone mineral content 1.1598024248335e-06 4.88984496910732e-05 1.25757903457579 0.379807692307692 22.3 22 3 short snout 0.000400443794784568 0.00717119017864122 1.2569894522811 0.37962962962963 22.3 22 3 reduced female fertility 3.16337411974815e-07 1.68404599575993e-05 1.25593227023545 0.379310344827586 22.3 22 3 increased circulating triglyceride level 4.72728565908108e-05 0.00118182141477027 1.25593227023545 0.379310344827586 22.3 22 3 lordosis 0.0537118132638722 0.246006611682694 1.25593227023545 0.379310344827586 22.3 22 3 aphagia 0.0537118132638722 0.246006611682694 1.25593227023545 0.379310344827586 22.3 22 3 abnormal CD8-positive, alpha-beta T cell physiology 0.0537118132638722 0.246006611682694 1.25593227023545 0.379310344827586 22.3 22 3 increased double-positive T cell number 0.0537118132638722 0.246006611682694 1.25593227023545 0.379310344827586 22.3 22 3 polychromatophilia 0.0537118132638722 0.246006611682694 1.25593227023545 0.379310344827586 22.3 22 3 no abnormal phenotype detected 1.55239231952591e-45 3.8615758948207e-42 1.25573484834335 0.379250720461095 22.3 22 3 abnormal immune system physiology 0.000164799234780225 0.00333283005297406 1.25501149877633 0.379032258064516 22.3 22 3 increased tumor incidence 0.000164799234780225 0.00333283005297406 1.25501149877633 0.379032258064516 22.3 22 3 decreased grip strength 7.00214995219152e-07 3.16688145565026e-05 1.25488957013563 0.378995433789954 22.3 22 3 alopecia 0.000909639234730805 0.0136308891348969 1.25473042117302 0.378947368421053 22.3 22 3 decreased T cell number 1.96825898949069e-05 0.00056601667472348 1.25451393904377 0.37888198757764 22.3 22 3 reduced male fertility 4.5409791665691e-07 2.23676944095854e-05 1.25442334079584 0.378854625550661 22.3 22 3 abnormal T cell activation 0.00328743475956117 0.0357095806306045 1.25284644156165 0.378378378378378 22.3 22 3 abnormal long bone metaphysis morphology 0.0323742433414028 0.182817094918818 1.25284644156165 0.378378378378378 22.3 22 3 increased circulating phosphate level 0.0323742433414028 0.182817094918818 1.25284644156165 0.378378378378378 22.3 22 3 decreased circulating chloride level 0.0323742433414028 0.182817094918818 1.25284644156165 0.378378378378378 22.3 22 3 abnormal calcium ion homeostasis 0.0323742433414028 0.182817094918818 1.25284644156165 0.378378378378378 22.3 22 3 increased trabecular bone volume 0.0323742433414028 0.182817094918818 1.25284644156165 0.378378378378378 22.3 22 3 abnormal respiratory electron transport chain 0.0323742433414028 0.182817094918818 1.25284644156165 0.378378378378378 22.3 22 3 decreased osteoclast cell number 0.0198271947271077 0.124235045705799 1.25085779641632 0.377777777777778 22.3 22 3 abnormal metabolism 0.0198271947271077 0.124235045705799 1.25085779641632 0.377777777777778 22.3 22 3 cardiomyopathy 0.0198271947271077 0.124235045705799 1.25085779641632 0.377777777777778 22.3 22 3 cardiac hypertrophy 0.000843424183852562 0.0130784016426377 1.25010698141247 0.377551020408163 22.3 22 3 abnormal placenta development 0.0122781168236346 0.088297427348358 1.24946949697523 0.377358490566038 22.3 22 3 decreased total body fat amount 1.54235408995274e-09 1.39512938136634e-07 1.24909540431147 0.377245508982036 22.3 22 3 weight loss 1.09943420226385e-05 0.00033556350651918 1.24875551440553 0.377142857142857 22.3 22 3 abnormal maternal nurturing 0.00766548448597803 0.0662079606210776 1.24844534164984 0.377049180327869 22.3 22 3 microcephaly 0.00481569291379147 0.0476384518936632 1.2476586716173 0.376811594202899 22.3 22 3 lethargy 0.00122556820245224 0.0173215960431816 1.24611070800487 0.376344086021505 22.3 22 3 male infertility 2.21292837878291e-13 4.58721611851874e-11 1.24412882218697 0.375745526838966 22.3 22 3 increased susceptibility to weight loss 0.02964506772873 0.169404512759124 1.24166031261914 0.375 22.3 22 3 abnormal auditory brainstem response waveform shape 0.0489543217010766 0.243824438155151 1.24166031261914 0.375 22.3 22 3 abnormal bone marrow cell number 0.144925801990664 0.448108057739933 1.24166031261914 0.375 22.3 22 3 disorganized retinal layers 0.144925801990664 0.448108057739933 1.24166031261914 0.375 22.3 22 3 disorganized yolk sac vascular plexus 0.144925801990664 0.448108057739933 1.24166031261914 0.375 22.3 22 3 abnormal meiosis 0.144925801990664 0.448108057739933 1.24166031261914 0.375 22.3 22 3 small pancreas 0.144925801990664 0.448108057739933 1.24166031261914 0.375 22.3 22 3 decreased circulating prolactin level 0.144925801990664 0.448108057739933 1.24166031261914 0.375 22.3 22 3 decreased midbrain size 0.144925801990664 0.448108057739933 1.24166031261914 0.375 22.3 22 3 abnormal suckling behavior 0.00178253657251704 0.023094061063209 1.24166031261914 0.375 22.3 22 3 abnormal cardiovascular system morphology 0.0182121359558198 0.118283781175201 1.24166031261914 0.375 22.3 22 3 abnormal foregut morphology 0.0826366884895946 0.336109828065709 1.24166031261914 0.375 22.3 22 3 abnormal adrenal gland morphology 0.0826366884895946 0.336109828065709 1.24166031261914 0.375 22.3 22 3 ocular hypertelorism 0.0826366884895946 0.336109828065709 1.24166031261914 0.375 22.3 22 3 abnormal cardiac muscle contractility 0.0826366884895946 0.336109828065709 1.24166031261914 0.375 22.3 22 3 prolonged QT interval 0.0826366884895946 0.336109828065709 1.24166031261914 0.375 22.3 22 3 decreased ovulation rate 0.0826366884895946 0.336109828065709 1.24166031261914 0.375 22.3 22 3 increased circulating total protein level 0.0826366884895946 0.336109828065709 1.24166031261914 0.375 22.3 22 3 abnormal cellular extravasation 0.0826366884895946 0.336109828065709 1.24166031261914 0.375 22.3 22 3 abnormal inner cell mass apoptosis 0.0826366884895946 0.336109828065709 1.24166031261914 0.375 22.3 22 3 abnormal neuron morphology 0.00104939824681653 0.0153551655232712 1.23747963816588 0.373737373737374 22.3 22 3 abnormal cranium morphology 0.000163443207406477 0.00333249982314436 1.2354828981285 0.373134328358209 22.3 22 3 decreased compact bone thickness 0.006513237739779 0.0585955836444855 1.2354828981285 0.373134328358209 22.3 22 3 abnormal thoracic vertebrae morphology 0.0103979275933503 0.0826352871835748 1.23464528260434 0.372881355932203 22.3 22 3 increased hemoglobin content 0.0103979275933503 0.0826352871835748 1.23464528260434 0.372881355932203 22.3 22 3 distended abdomen 0.0167169351876452 0.111483582518144 1.23354488573927 0.372549019607843 22.3 22 3 increased circulating creatinine level 0.00239590782810012 0.0295158293098367 1.2320350388779 0.372093023255814 22.3 22 3 abnormal left-right axis patterning 0.027128091551977 0.162214249364286 1.2320350388779 0.372093023255814 22.3 22 3 increased urine protein level 0.00378313252462424 0.0398751786228932 1.2310478313147 0.371794871794872 22.3 22 3 increased circulating HDL cholesterol level 0.000896805077983517 0.01349258297648 1.22983497630848 0.371428571428571 22.3 22 3 abnormal kidney morphology 2.24182120510157e-05 0.000633696619055699 1.22983497630848 0.371428571428571 22.3 22 3 hypoactivity 6.7837400282164e-10 7.03106388341179e-08 1.22958404078995 0.371352785145889 22.3 22 3 abnormal myocardial fiber morphology 0.00140615495989527 0.01913062640832 1.22885969083956 0.371134020618557 22.3 22 3 abnormal neuronal precursor proliferation 0.0153362124582073 0.104374359753189 1.22633117295717 0.37037037037037 22.3 22 3 thin epidermis 0.0747361299128195 0.313501050856895 1.22633117295717 0.37037037037037 22.3 22 3 enlarged liver 0.00129812687950513 0.018039612361838 1.22510484178422 0.37 22.3 22 3 seminiferous tubule degeneration 0.00552169025821579 0.0525246826665843 1.22465126724079 0.36986301369863 22.3 22 3 abnormal trabecular bone morphology 0.000489762794601394 0.00831593823597931 1.22427011216229 0.369747899159664 22.3 22 3 increased circulating cholesterol level 2.75609737084465e-05 0.00075626958988444 1.22284727757945 0.369318181818182 22.3 22 3 decreased inflammatory response 0.00321284230060637 0.0353772944844567 1.22195141876804 0.369047619047619 22.3 22 3 increased food intake 0.00321284230060637 0.0353772944844567 1.22195141876804 0.369047619047619 22.3 22 3 abnormal craniofacial morphology 0.0011979602330204 0.0173215960431816 1.22156872180006 0.368932038834951 22.3 22 3 abnormal facial morphology 0.0140636779941776 0.0965059283048741 1.21987679836266 0.368421052631579 22.3 22 3 impaired branching involved in ureteric bud morphogenesis 0.0406178706800744 0.211235481556845 1.21987679836266 0.368421052631579 22.3 22 3 kyphoscoliosis 0.12927822717949 0.438828735119033 1.21987679836266 0.368421052631579 22.3 22 3 short vibrissae 0.12927822717949 0.438828735119033 1.21987679836266 0.368421052631579 22.3 22 3 abnormal stationary movement 0.12927822717949 0.438828735119033 1.21987679836266 0.368421052631579 22.3 22 3 increased left ventricle weight 0.12927822717949 0.438828735119033 1.21987679836266 0.368421052631579 22.3 22 3 abnormal sternebra morphology 0.12927822717949 0.438828735119033 1.21987679836266 0.368421052631579 22.3 22 3 decreased liver regeneration 0.12927822717949 0.438828735119033 1.21987679836266 0.368421052631579 22.3 22 3 decreased fertilization frequency 0.12927822717949 0.438828735119033 1.21987679836266 0.368421052631579 22.3 22 3 abnormal spleen morphology 3.65230898858146e-05 0.000961388212602792 1.21787371659195 0.367816091954023 22.3 22 3 absent kidney 0.0226893320940091 0.14092313004706 1.21632030623916 0.36734693877551 22.3 22 3 increased T cell derived lymphoma incidence 0.0226893320940091 0.14092313004706 1.21632030623916 0.36734693877551 22.3 22 3 ataxia 1.11702733374653e-05 0.000338854328377376 1.21297509087546 0.366336633663366 22.3 22 3 increased blood urea nitrogen level 0.000195099699601295 0.00383644666212033 1.21026200586325 0.36551724137931 22.3 22 3 decreased kidney weight 0.0207428343963128 0.12980578757441 1.20982286870583 0.365384615384615 22.3 22 3 hydroencephaly 0.000866252256601219 0.0132196471674573 1.20926917402907 0.365217391304348 22.3 22 3 abnormal nervous system physiology 0.000866252256601219 0.0132196471674573 1.20926917402907 0.365217391304348 22.3 22 3 abnormal skeleton morphology 0.000866252256601219 0.0132196471674573 1.20926917402907 0.365217391304348 22.3 22 3 increased T cell proliferation 0.00135474626584659 0.0185161062433703 1.20684740665785 0.364485981308411 22.3 22 3 hyperglycemia 0.00363145309010378 0.0386862507992855 1.20403424253977 0.363636363636364 22.3 22 3 increased circulating calcium level 0.0189610251043667 0.122190543904436 1.20403424253977 0.363636363636364 22.3 22 3 decreased circulating calcium level 0.0189610251043667 0.122190543904436 1.20403424253977 0.363636363636364 22.3 22 3 abnormal circadian rhythm 0.0336902166619491 0.188961474513187 1.20403424253977 0.363636363636364 22.3 22 3 renal interstitial fibrosis 0.0336902166619491 0.188961474513187 1.20403424253977 0.363636363636364 22.3 22 3 decreased macrophage cell number 0.0336902166619491 0.188961474513187 1.20403424253977 0.363636363636364 22.3 22 3 abnormal aorta morphology 0.0612090155620873 0.261386139417497 1.20403424253977 0.363636363636364 22.3 22 3 abnormal epidermis stratum basale morphology 0.0612090155620873 0.261386139417497 1.20403424253977 0.363636363636364 22.3 22 3 single kidney 0.0612090155620873 0.261386139417497 1.20403424253977 0.363636363636364 22.3 22 3 abnormal QRS complex 0.0612090155620873 0.261386139417497 1.20403424253977 0.363636363636364 22.3 22 3 cardiovascular system phenotype 0.0612090155620873 0.261386139417497 1.20403424253977 0.363636363636364 22.3 22 3 decreased sensitivity to xenobiotic induced morbidity/mortality 0.0612090155620873 0.261386139417497 1.20403424253977 0.363636363636364 22.3 22 3 abnormal abdominal fat pad morphology 0.115599925359456 0.413153468867307 1.20403424253977 0.363636363636364 22.3 22 3 abnormal enterocyte morphology 0.115599925359456 0.413153468867307 1.20403424253977 0.363636363636364 22.3 22 3 abnormal tail movements 0.115599925359456 0.413153468867307 1.20403424253977 0.363636363636364 22.3 22 3 abnormal cochlear sensory epithelium morphology 0.115599925359456 0.413153468867307 1.20403424253977 0.363636363636364 22.3 22 3 abnormal female reproductive system physiology 0.115599925359456 0.413153468867307 1.20403424253977 0.363636363636364 22.3 22 3 abnormal retinal layer morphology 0.115599925359456 0.413153468867307 1.20403424253977 0.363636363636364 22.3 22 3 rough coat 0.115599925359456 0.413153468867307 1.20403424253977 0.363636363636364 22.3 22 3 decreased body size 1.78528971959391e-17 6.83216642690746e-15 1.20327983511963 0.363408521303258 22.3 22 3 decreased litter size 4.62205489420499e-07 2.25438461751665e-05 1.20189183285554 0.362989323843416 22.3 22 3 thrombocytosis 0.0173312147796242 0.114808508435917 1.1988444397702 0.362068965517241 22.3 22 3 abnormal cell nucleus morphology 0.0306870743677327 0.174877657479347 1.19762980507945 0.361702127659574 22.3 22 3 abnormal neuromuscular synapse morphology 0.00908836106648189 0.0747901029758895 1.19567289363324 0.361111111111111 22.3 22 3 abnormal inflammatory response 0.00908836106648189 0.0747901029758895 1.19567289363324 0.361111111111111 22.3 22 3 abnormal forebrain development 0.00908836106648189 0.0747901029758895 1.19567289363324 0.361111111111111 22.3 22 3 abnormal heart left ventricle morphology 0.00908836106648189 0.0747901029758895 1.19567289363324 0.361111111111111 22.3 22 3 reduced long term depression 0.0554395650477024 0.24716657302525 1.19567289363324 0.361111111111111 22.3 22 3 impaired wound healing 0.0554395650477024 0.24716657302525 1.19567289363324 0.361111111111111 22.3 22 3 abnormal retinal blood vessel morphology 0.0554395650477024 0.24716657302525 1.19567289363324 0.361111111111111 22.3 22 3 abnormal long bone morphology 0.0158412471949631 0.106933792123394 1.1941651094042 0.360655737704918 22.3 22 3 decreased heart rate 0.00258773387491759 0.0313999415310122 1.19199390011437 0.36 22.3 22 3 kidney inflammation 0.0279561338123777 0.165761811008716 1.19199390011437 0.36 22.3 22 3 decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 0.103591110197311 0.380063254595592 1.19199390011437 0.36 22.3 22 3 increased circulating alanine transaminase level 0.00762640723716507 0.0659850017476456 1.18859790609695 0.358974358974359 22.3 22 3 abnormal spermatogenesis 6.79983918985106e-05 0.00158080373689295 1.1876750816357 0.358695652173913 22.3 22 3 decreased heart weight 0.00698584728009232 0.06151254905922 1.18545346719193 0.358024691358025 22.3 22 3 increased body weight 1.48912312527739e-05 0.000438366127115681 1.18253363106585 0.357142857142857 22.3 22 3 improved glucose tolerance 4.89776528901191e-05 0.00121831911564171 1.18253363106585 0.357142857142857 22.3 22 3 limb grasping 8.90374038686024e-05 0.00196871592998354 1.18253363106585 0.357142857142857 22.3 22 3 abnormal cartilage morphology 0.0455612350955635 0.230587125737974 1.18253363106585 0.357142857142857 22.3 22 3 abnormal spleen germinal center morphology 0.0930053963412265 0.347113163389049 1.18253363106585 0.357142857142857 22.3 22 3 increased bone resorption 0.0930053963412265 0.347113163389049 1.18253363106585 0.357142857142857 22.3 22 3 increased triglyceride level 0.0930053963412265 0.347113163389049 1.18253363106585 0.357142857142857 22.3 22 3 corneal vascularization 0.0930053963412265 0.347113163389049 1.18253363106585 0.357142857142857 22.3 22 3 subcutaneous edema 0.0930053963412265 0.347113163389049 1.18253363106585 0.357142857142857 22.3 22 3 abnormal zigzag hair morphology 0.207549925610229 0.517256558031924 1.18253363106585 0.357142857142857 22.3 22 3 translucent skin 0.207549925610229 0.517256558031924 1.18253363106585 0.357142857142857 22.3 22 3 irregularly shaped pupil 0.207549925610229 0.517256558031924 1.18253363106585 0.357142857142857 22.3 22 3 decreased coping response 0.207549925610229 0.517256558031924 1.18253363106585 0.357142857142857 22.3 22 3 abnormal ventral body wall morphology 0.207549925610229 0.517256558031924 1.18253363106585 0.357142857142857 22.3 22 3 abnormal sagittal suture morphology 0.207549925610229 0.517256558031924 1.18253363106585 0.357142857142857 22.3 22 3 abnormal pancreas development 0.207549925610229 0.517256558031924 1.18253363106585 0.357142857142857 22.3 22 3 lysosomal protein accumulation 0.207549925610229 0.517256558031924 1.18253363106585 0.357142857142857 22.3 22 3 abnormal glucose tolerance 0.207549925610229 0.517256558031924 1.18253363106585 0.357142857142857 22.3 22 3 spina bifida occulta 0.207549925610229 0.517256558031924 1.18253363106585 0.357142857142857 22.3 22 3 pulmonary alveolar hemorrhage 0.207549925610229 0.517256558031924 1.18253363106585 0.357142857142857 22.3 22 3 abnormal fertility/fecundity 0.0110614130029695 0.0861268876420591 1.17929381289854 0.356164383561644 22.3 22 3 decreased percent body fat/body weight 0.0110614130029695 0.0861268876420591 1.17929381289854 0.356164383561644 22.3 22 3 small placenta 0.0413387804880687 0.21158480753924 1.17727792603889 0.355555555555556 22.3 22 3 abnormal axial skeleton morphology 0.0101134434619258 0.0806320211908351 1.17630976984971 0.355263157894737 22.3 22 3 hypoglycemia 0.00491867887185664 0.0483605284337683 1.17490438183316 0.354838709677419 22.3 22 3 increased eosinophil cell number 0.0192959131563466 0.124187798127845 1.17490438183316 0.354838709677419 22.3 22 3 abnormal eyelid morphology 0.0836405402485952 0.336109828065709 1.17490438183316 0.354838709677419 22.3 22 3 decreased double-negative T cell number 0.0836405402485952 0.336109828065709 1.17490438183316 0.354838709677419 22.3 22 3 decreased susceptibility to bacterial infection induced morbidity/mortality 0.0836405402485952 0.336109828065709 1.17490438183316 0.354838709677419 22.3 22 3 abnormal thrombosis 0.0340866057895047 0.190754627449703 1.16862147070037 0.352941176470588 22.3 22 3 short maxilla 0.0753295210050169 0.315192907485247 1.16862147070037 0.352941176470588 22.3 22 3 abnormal retinal photoreceptor morphology 0.0753295210050169 0.315192907485247 1.16862147070037 0.352941176470588 22.3 22 3 decreased regulatory T cell number 0.0753295210050169 0.315192907485247 1.16862147070037 0.352941176470588 22.3 22 3 abnormal interatrial septum morphology 0.1822489480201 0.517256558031924 1.16862147070037 0.352941176470588 22.3 22 3 enlarged sebaceous gland 0.1822489480201 0.517256558031924 1.16862147070037 0.352941176470588 22.3 22 3 abnormal glutamate-mediated receptor currents 0.1822489480201 0.517256558031924 1.16862147070037 0.352941176470588 22.3 22 3 decreased vasoconstriction 0.1822489480201 0.517256558031924 1.16862147070037 0.352941176470588 22.3 22 3 absence seizures 0.1822489480201 0.517256558031924 1.16862147070037 0.352941176470588 22.3 22 3 increased hepatoma incidence 0.1822489480201 0.517256558031924 1.16862147070037 0.352941176470588 22.3 22 3 abnormal survival 0.1822489480201 0.517256558031924 1.16862147070037 0.352941176470588 22.3 22 3 abnormal ductus venosus valve morphology 0.1822489480201 0.517256558031924 1.16862147070037 0.352941176470588 22.3 22 3 decreased body fat mass 0.1822489480201 0.517256558031924 1.16862147070037 0.352941176470588 22.3 22 3 decreased liver weight 0.014646771679755 0.100092979542282 1.1658782278114 0.352112676056338 22.3 22 3 abnormal intestine morphology 0.0133668623974879 0.0937779661717985 1.16335741002154 0.351351351351351 22.3 22 3 small seminiferous tubules 0.0133668623974879 0.0937779661717985 1.16335741002154 0.351351351351351 22.3 22 3 abnormal breathing pattern 0.0679332809719482 0.287387817036941 1.16335741002154 0.351351351351351 22.3 22 3 increased insulin secretion 0.0679332809719482 0.287387817036941 1.16335741002154 0.351351351351351 22.3 22 3 abnormal chromosome morphology 0.0679332809719482 0.287387817036941 1.16335741002154 0.351351351351351 22.3 22 3 abnormal hair follicle development 0.0679332809719482 0.287387817036941 1.16335741002154 0.351351351351351 22.3 22 3 increased total body fat amount 0.00121381674086585 0.0173215960431816 1.16135392424079 0.350746268656716 22.3 22 3 polyuria 0.0122014470444969 0.088297427348358 1.16103301959192 0.350649350649351 22.3 22 3 abnormal retinal pigment epithelium morphology 0.0111399946908273 0.0863262828455854 1.15888295844453 0.35 22.3 22 3 perinatal lethality 0.0613350778056737 0.261699838836387 1.15888295844453 0.35 22.3 22 3 waved hair 0.160998340000037 0.491692290669234 1.15888295844453 0.35 22.3 22 3 brain inflammation 0.160998340000037 0.491692290669234 1.15888295844453 0.35 22.3 22 3 anencephaly 0.160998340000037 0.491692290669234 1.15888295844453 0.35 22.3 22 3 abnormal optic stalk morphology 0.160998340000037 0.491692290669234 1.15888295844453 0.35 22.3 22 3 abnormal postnatal subventricular zone morphology 0.160998340000037 0.491692290669234 1.15888295844453 0.35 22.3 22 3 decreased muscle cell glucose uptake 0.160998340000037 0.491692290669234 1.15888295844453 0.35 22.3 22 3 impaired coordination 4.22659169441035e-07 2.12396905855469e-05 1.15792599481245 0.34971098265896 22.3 22 3 increased bone mineral content 0.0038011718278856 0.0399806127774437 1.15432640683859 0.348623853211009 22.3 22 3 abnormal skin morphology 0.0212190496952795 0.132452662777937 1.15386614910061 0.348484848484849 22.3 22 3 increased startle reflex 0.00848847116090118 0.0707372596741765 1.15330246265748 0.348314606741573 22.3 22 3 reduced long term potentiation 0.00347987143976587 0.0371509880103759 1.1529702902892 0.348214285714286 22.3 22 3 abnormal cranial nerve morphology 0.142879651292596 0.443988922661253 1.15168492764674 0.347826086956522 22.3 22 3 abnormal nasal cavity morphology 0.142879651292596 0.443988922661253 1.15168492764674 0.347826086956522 22.3 22 3 abnormal sacral vertebrae morphology 0.142879651292596 0.443988922661253 1.15168492764674 0.347826086956522 22.3 22 3 increased susceptibility to age related obesity 0.142879651292596 0.443988922661253 1.15168492764674 0.347826086956522 22.3 22 3 decreased effector memory CD8-positive, alpha-beta T cell number 0.142879651292596 0.443988922661253 1.15168492764674 0.347826086956522 22.3 22 3 abnormal vertebral artery topology 0.142879651292596 0.443988922661253 1.15168492764674 0.347826086956522 22.3 22 3 abnormal digit morphology 0.0176033730697938 0.115689274798183 1.14968547464735 0.347222222222222 22.3 22 3 increased susceptibility to bacterial infection induced morbidity/mortality 0.0176033730697938 0.115689274798183 1.14968547464735 0.347222222222222 22.3 22 3 abnormal long bone hypertrophic chondrocyte zone 0.0454113020646841 0.23006235007312 1.14874695589254 0.346938775510204 22.3 22 3 decreased urine osmolality 0.0454113020646841 0.23006235007312 1.14874695589254 0.346938775510204 22.3 22 3 abnormal T cell differentiation 0.0059229802858704 0.0539685474765664 1.14740886974706 0.346534653465347 22.3 22 3 abnormal pulmonary alveolus morphology 0.0059229802858704 0.0539685474765664 1.14740886974706 0.346534653465347 22.3 22 3 abnormal nasal bone morphology 0.127261433061565 0.438828735119033 1.1461479808792 0.346153846153846 22.3 22 3 abnormal xiphoid process morphology 0.127261433061565 0.438828735119033 1.1461479808792 0.346153846153846 22.3 22 3 abnormal stomach morphology 0.127261433061565 0.438828735119033 1.1461479808792 0.346153846153846 22.3 22 3 increased susceptibility to otitis media 0.127261433061565 0.438828735119033 1.1461479808792 0.346153846153846 22.3 22 3 abnormal ocular fundus morphology 0.127261433061565 0.438828735119033 1.1461479808792 0.346153846153846 22.3 22 3 increased rib number 0.0146235269424961 0.100071590837577 1.1461479808792 0.346153846153846 22.3 22 3 absent gastric milk in neonates 0.0146235269424961 0.100071590837577 1.1461479808792 0.346153846153846 22.3 22 3 abnormal enzyme/coenzyme level 0.0338631792298635 0.189717698951093 1.14175660930495 0.344827586206897 22.3 22 3 increased susceptibility to induced arthritis 0.113686229539834 0.408662566445574 1.14175660930495 0.344827586206897 22.3 22 3 short sternum 0.113686229539834 0.408662566445574 1.14175660930495 0.344827586206897 22.3 22 3 decreased bone strength 0.113686229539834 0.408662566445574 1.14175660930495 0.344827586206897 22.3 22 3 abnormal retinal pigmentation 0.011097062968234 0.086127750806496 1.14175660930495 0.344827586206897 22.3 22 3 abnormal tooth morphology 0.0279345580245743 0.165761811008716 1.13818861990088 0.34375 22.3 22 3 increased sacral vertebrae number 0.0279345580245743 0.165761811008716 1.13818861990088 0.34375 22.3 22 3 kidney cortex cysts 0.101809511868724 0.374355004838803 1.13818861990088 0.34375 22.3 22 3 polydipsia 0.101809511868724 0.374355004838803 1.13818861990088 0.34375 22.3 22 3 abnormal diaphragm morphology 0.101809511868724 0.374355004838803 1.13818861990088 0.34375 22.3 22 3 abnormal heart atrium morphology 0.101809511868724 0.374355004838803 1.13818861990088 0.34375 22.3 22 3 increased fatty acid level 0.101809511868724 0.374355004838803 1.13818861990088 0.34375 22.3 22 3 postnatal lethality 0.000720723551980357 0.0114923066381483 1.13694197300066 0.343373493975904 22.3 22 3 abnormal midbrain development 0.0913639675118184 0.342351119473142 1.13523228582321 0.342857142857143 22.3 22 3 postnatal lethality, complete penetrance 5.38346875901805e-07 2.6002676772927e-05 1.1322912695387 0.341968911917098 22.3 22 3 abnormal response/metabolism to endogenous compounds 0.0158638971415486 0.106941583034152 1.13061752043369 0.341463414634146 22.3 22 3 Leydig cell hyperplasia 0.0739576963824509 0.310497501690036 1.13061752043369 0.341463414634146 22.3 22 3 increased tumor growth/size 0.0739576963824509 0.310497501690036 1.13061752043369 0.341463414634146 22.3 22 3 palatal shelves fail to meet at midline 0.0739576963824509 0.310497501690036 1.13061752043369 0.341463414634146 22.3 22 3 teratozoospermia 0.013177695418627 0.0928598225321094 1.12878210238103 0.340909090909091 22.3 22 3 hypertension 0.0666840214020721 0.283307435077121 1.12878210238103 0.340909090909091 22.3 22 3 increased circulating chloride level 0.0544033584370842 0.246865191189718 1.12577201677469 0.34 22.3 22 3 abnormal circulating protein level 0.0544033584370842 0.246865191189718 1.12577201677469 0.34 22.3 22 3 abnormal coat/ hair morphology 0.0492138432616749 0.244594275950882 1.12452254727771 0.339622641509434 22.3 22 3 decreased monocyte cell number 0.0332231338971199 0.186974084997932 1.12067802574856 0.338461538461538 22.3 22 3 female infertility 4.93541729325562e-05 0.00121849791726954 1.12029501890449 0.338345864661654 22.3 22 3 increased sensitivity to induced morbidity/mortality 0.000756734341069374 0.0120279659642816 1.11569477365778 0.33695652173913 22.3 22 3 hyperactivity 2.49805496955183e-06 9.41501778296995e-05 1.11559776515646 0.336927223719677 22.3 22 3 decreased birth weight 0.0129267545555915 0.0913502896506646 1.11531592993158 0.336842105263158 22.3 22 3 increased bone mineral density 0.00746115003819806 0.0647804911693462 1.11346529509209 0.336283185840708 22.3 22 3 increased circulating glucose level 0.00387841160093582 0.0405359195686044 1.10369805566146 0.333333333333333 22.3 22 3 abnormal motor coordination/ balance 0.0138264490487056 0.0952722770322861 1.10369805566146 0.333333333333333 22.3 22 3 abnormal limb morphology 0.0293448705017089 0.168386079291813 1.10369805566146 0.333333333333333 22.3 22 3 increased circulating aspartate transaminase level 0.043265017813113 0.22031060759492 1.10369805566146 0.333333333333333 22.3 22 3 abnormal cochlea morphology 0.0583327602987323 0.252744166699294 1.10369805566146 0.333333333333333 22.3 22 3 abnormal chondrocyte morphology 0.0583327602987323 0.252744166699294 1.10369805566146 0.333333333333333 22.3 22 3 altered response to myocardial infarction 0.079356641859074 0.330375977614137 1.10369805566146 0.333333333333333 22.3 22 3 disheveled coat 0.0881559270258943 0.339424545431096 1.10369805566146 0.333333333333333 22.3 22 3 abnormal heart looping 0.0980841543462122 0.365246008886531 1.10369805566146 0.333333333333333 22.3 22 3 abnormal iris morphology 0.0980841543462122 0.365246008886531 1.10369805566146 0.333333333333333 22.3 22 3 increased autoantibody level 0.0980841543462122 0.365246008886531 1.10369805566146 0.333333333333333 22.3 22 3 belly spot 0.122109760022042 0.431844549480387 1.10369805566146 0.333333333333333 22.3 22 3 abnormal ovarian folliculogenesis 0.122109760022042 0.431844549480387 1.10369805566146 0.333333333333333 22.3 22 3 increased osteoblast cell number 0.122109760022042 0.431844549480387 1.10369805566146 0.333333333333333 22.3 22 3 diarrhea 0.122109760022042 0.431844549480387 1.10369805566146 0.333333333333333 22.3 22 3 abnormal trigeminal nerve morphology 0.153524084635938 0.471470568557895 1.10369805566146 0.333333333333333 22.3 22 3 abnormal trigeminal ganglion morphology 0.153524084635938 0.471470568557895 1.10369805566146 0.333333333333333 22.3 22 3 abnormal type II pneumocyte morphology 0.153524084635938 0.471470568557895 1.10369805566146 0.333333333333333 22.3 22 3 cryptorchism 0.153524084635938 0.471470568557895 1.10369805566146 0.333333333333333 22.3 22 3 thick interventricular septum 0.153524084635938 0.471470568557895 1.10369805566146 0.333333333333333 22.3 22 3 lowered ear position 0.222861870273718 0.517256558031924 1.10369805566146 0.333333333333333 22.3 22 3 abnormal heart shape 0.222861870273718 0.517256558031924 1.10369805566146 0.333333333333333 22.3 22 3 underdeveloped hair follicles 0.222861870273718 0.517256558031924 1.10369805566146 0.333333333333333 22.3 22 3 abnormal anxiety-related response 0.195804817873389 0.517256558031924 1.10369805566146 0.333333333333333 22.3 22 3 abnormal hematopoietic system physiology 0.195804817873389 0.517256558031924 1.10369805566146 0.333333333333333 22.3 22 3 eye inflammation 0.222861870273718 0.517256558031924 1.10369805566146 0.333333333333333 22.3 22 3 abnormal thymus cortex morphology 0.222861870273718 0.517256558031924 1.10369805566146 0.333333333333333 22.3 22 3 abnormal redox activity 0.222861870273718 0.517256558031924 1.10369805566146 0.333333333333333 22.3 22 3 absent ureter 0.222861870273718 0.517256558031924 1.10369805566146 0.333333333333333 22.3 22 3 abnormal glycogen homeostasis 0.222861870273718 0.517256558031924 1.10369805566146 0.333333333333333 22.3 22 3 complete atrioventricular septal defect 0.195804817873389 0.517256558031924 1.10369805566146 0.333333333333333 22.3 22 3 primary atelectasis 0.222861870273718 0.517256558031924 1.10369805566146 0.333333333333333 22.3 22 3 increased bone ossification 0.195804817873389 0.517256558031924 1.10369805566146 0.333333333333333 22.3 22 3 abnormal coat appearance 0.0355867725726507 0.197790637758815 1.10369805566146 0.333333333333333 22.3 22 3 abnormal kidney development 0.0477563509931585 0.241205935219253 1.10369805566146 0.333333333333333 22.3 22 3 epidermal hyperplasia 0.0477563509931585 0.241205935219253 1.10369805566146 0.333333333333333 22.3 22 3 abnormal intestinal epithelium morphology 0.07153415389902 0.301084954016603 1.10369805566146 0.333333333333333 22.3 22 3 abnormal kidney physiology 0.07153415389902 0.301084954016603 1.10369805566146 0.333333333333333 22.3 22 3 abnormal heart tube morphology 0.136720510439096 0.438828735119033 1.10369805566146 0.333333333333333 22.3 22 3 gastrointestinal hemorrhage 0.136720510439096 0.438828735119033 1.10369805566146 0.333333333333333 22.3 22 3 increased metastatic potential 0.136720510439096 0.438828735119033 1.10369805566146 0.333333333333333 22.3 22 3 abnormal lactation 0.136720510439096 0.438828735119033 1.10369805566146 0.333333333333333 22.3 22 3 enhanced paired-pulse facilitation 0.136720510439096 0.438828735119033 1.10369805566146 0.333333333333333 22.3 22 3 curly vibrissae 0.173001132694097 0.517256558031924 1.10369805566146 0.333333333333333 22.3 22 3 abnormal nursing 0.173001132694097 0.517256558031924 1.10369805566146 0.333333333333333 22.3 22 3 abnormal sensory capabilities/reflexes/nociception 0.173001132694097 0.517256558031924 1.10369805566146 0.333333333333333 22.3 22 3 small lymph nodes 0.173001132694097 0.517256558031924 1.10369805566146 0.333333333333333 22.3 22 3 abnormal osteoblast morphology 0.173001132694097 0.517256558031924 1.10369805566146 0.333333333333333 22.3 22 3 absent incisors 0.255565152124402 0.558627694120782 1.10369805566146 0.333333333333333 22.3 22 3 decreased chondrocyte number 0.255565152124402 0.558627694120782 1.10369805566146 0.333333333333333 22.3 22 3 decreased hepatocyte number 0.255565152124402 0.558627694120782 1.10369805566146 0.333333333333333 22.3 22 3 abnormal enteric neuron morphology 0.255565152124402 0.558627694120782 1.10369805566146 0.333333333333333 22.3 22 3 vagina atresia 0.255565152124402 0.558627694120782 1.10369805566146 0.333333333333333 22.3 22 3 hyperpigmentation 0.255565152124402 0.558627694120782 1.10369805566146 0.333333333333333 22.3 22 3 abnormal seizure response to electrical stimulation 0.255565152124402 0.558627694120782 1.10369805566146 0.333333333333333 22.3 22 3 joint inflammation 0.255565152124402 0.558627694120782 1.10369805566146 0.333333333333333 22.3 22 3 decreased aggression towards males 0.255565152124402 0.558627694120782 1.10369805566146 0.333333333333333 22.3 22 3 abnormal ear development 0.255565152124402 0.558627694120782 1.10369805566146 0.333333333333333 22.3 22 3 abnormal trophectoderm morphology 0.255565152124402 0.558627694120782 1.10369805566146 0.333333333333333 22.3 22 3 abnormal cerebral aqueduct morphology 0.255565152124402 0.558627694120782 1.10369805566146 0.333333333333333 22.3 22 3 abnormal microglial cell activation 0.255565152124402 0.558627694120782 1.10369805566146 0.333333333333333 22.3 22 3 increased circulating insulin level 0.00264514166839633 0.031863389346905 1.09679994281357 0.33125 22.3 22 3 small kidney 0.0234681177628253 0.14485593780404 1.09115603230167 0.329545454545455 22.3 22 3 sparse hair 0.0283667062513147 0.165761811008716 1.09023832327534 0.329268292682927 22.3 22 3 impaired fertilization 0.0417009968497083 0.213000471588602 1.08793094058058 0.328571428571429 22.3 22 3 abnormal action potential 0.0417009968497083 0.213000471588602 1.08793094058058 0.328571428571429 22.3 22 3 abnormal lens morphology 0.00821828777325321 0.0695339824352631 1.08645277354175 0.328125 22.3 22 3 cyanosis 0.00146830091397213 0.0197961979593804 1.08645277354175 0.328125 22.3 22 3 abnormal contextual conditioning behavior 0.0685565216828073 0.289531999466864 1.08363081828579 0.327272727272727 22.3 22 3 abnormal joint morphology 0.0685565216828073 0.289531999466864 1.08363081828579 0.327272727272727 22.3 22 3 infertility 0.0155843824387852 0.105918446219886 1.08306818546218 0.327102803738318 22.3 22 3 cachexia 0.0170948071120436 0.113546949776257 1.08247309305258 0.326923076923077 22.3 22 3 abnormal leukocyte migration 0.0759326847601472 0.317183129035879 1.08247309305258 0.326923076923077 22.3 22 3 increased fluid intake 0.0841997790308192 0.336109828065709 1.08117360554592 0.326530612244898 22.3 22 3 impaired macrophage phagocytosis 0.103951689455127 0.381105125305273 1.07803065901817 0.325581395348837 22.3 22 3 abnormal lipid level 0.0329979822624504 0.186128074552937 1.0771029217901 0.325301204819277 22.3 22 3 increased brown adipose tissue amount 0.129194754874402 0.438828735119033 1.07386837848142 0.324324324324324 22.3 22 3 abnormal vocalization 0.129194754874402 0.438828735119033 1.07386837848142 0.324324324324324 22.3 22 3 abnormal pancreatic beta cell physiology 0.129194754874402 0.438828735119033 1.07386837848142 0.324324324324324 22.3 22 3 absent mature ovarian follicles 0.161996686720286 0.492955489657564 1.0680948925756 0.32258064516129 22.3 22 3 abnormal CD8-positive, alpha beta T cell morphology 0.161996686720286 0.492955489657564 1.0680948925756 0.32258064516129 22.3 22 3 abnormal T cell proliferation 0.161996686720286 0.492955489657564 1.0680948925756 0.32258064516129 22.3 22 3 neonatal lethality, complete penetrance 5.67560410982905e-06 0.000183351496405192 1.06739219856733 0.322368421052632 22.3 22 3 short limbs 0.0347111537255005 0.193813681015 1.06563950201796 0.32183908045977 22.3 22 3 abnormal coat/hair pigmentation 0.0189391625478532 0.122190543904436 1.06428026795926 0.321428571428571 22.3 22 3 abnormal neuron differentiation 0.0189391625478532 0.122190543904436 1.06428026795926 0.321428571428571 22.3 22 3 myoclonus 0.182190831722906 0.517256558031924 1.06428026795926 0.321428571428571 22.3 22 3 shortened head 0.182190831722906 0.517256558031924 1.06428026795926 0.321428571428571 22.3 22 3 increased circulating luteinizing hormone level 0.182190831722906 0.517256558031924 1.06428026795926 0.321428571428571 22.3 22 3 absent corpus callosum 0.182190831722906 0.517256558031924 1.06428026795926 0.321428571428571 22.3 22 3 abnormal retinal inner nuclear layer morphology 0.182190831722906 0.517256558031924 1.06428026795926 0.321428571428571 22.3 22 3 abnormal skeleton development 0.0420140661699864 0.214159814749675 1.06282034989622 0.320987654320988 22.3 22 3 testicular atrophy 0.0982216240161059 0.365484352640334 1.059550133435 0.32 22.3 22 3 abnormal vertebrae development 0.205664672692585 0.517256558031924 1.059550133435 0.32 22.3 22 3 cochlear outer hair cell degeneration 0.0561762558320967 0.248423886901939 1.05771063667556 0.319444444444444 22.3 22 3 cleft secondary palate 0.0330815599861962 0.186388177725171 1.05673218095246 0.319148936170213 22.3 22 3 hepatic necrosis 0.10909198976779 0.399068124334378 1.05673218095246 0.319148936170213 22.3 22 3 neuron degeneration 0.10909198976779 0.399068124334378 1.05673218095246 0.319148936170213 22.3 22 3 abnormal spatial learning 0.00673279176065634 0.0595238781587186 1.05629997965146 0.319018404907975 22.3 22 3 small ovary 0.0363498842752652 0.198290213014742 1.0551838554126 0.318681318681319 22.3 22 3 increased liver weight 0.0399579038414156 0.211235481556845 1.0535299622223 0.318181818181818 22.3 22 3 abnormal amino acid level 0.121343267879885 0.431844549480387 1.0535299622223 0.318181818181818 22.3 22 3 embryonic lethality, incomplete penetrance 0.121343267879885 0.431844549480387 1.0535299622223 0.318181818181818 22.3 22 3 abnormal basisphenoid bone morphology 0.233233767713224 0.51916688786277 1.0535299622223 0.318181818181818 22.3 22 3 increased coping response 0.233233767713224 0.51916688786277 1.0535299622223 0.318181818181818 22.3 22 3 aphakia 0.233233767713224 0.51916688786277 1.0535299622223 0.318181818181818 22.3 22 3 abnormal hair follicle morphology 0.0755641958357728 0.315909138052916 1.05114100539186 0.317460317460317 22.3 22 3 decreased anxiety-related response 0.0188948039513511 0.122190543904436 1.049859126117 0.317073170731707 22.3 22 3 abnormal excitatory postsynaptic potential 0.0483503404179414 0.243824438155151 1.04985912611699 0.317073170731707 22.3 22 3 abnormal cholesterol homeostasis 0.135194795273973 0.438828735119033 1.04985912611699 0.317073170731707 22.3 22 3 abnormal long bone epiphyseal plate morphology 0.0835483698622467 0.336109828065709 1.04851315287838 0.316666666666667 22.3 22 3 abnormal incisor morphology 0.0835483698622467 0.336109828065709 1.04851315287838 0.316666666666667 22.3 22 3 increased anxiety-related response 0.0137264108213091 0.0947141384688108 1.0481161391893 0.316546762589928 22.3 22 3 seizures 0.0248426246388595 0.1514608548754 1.04560868431085 0.315789473684211 22.3 22 3 abnormal retinal outer nuclear layer morphology 0.15091358282087 0.465465018309874 1.04560868431085 0.315789473684211 22.3 22 3 hyporesponsive to tactile stimuli 0.15091358282087 0.465465018309874 1.04560868431085 0.315789473684211 22.3 22 3 irregular coat pigmentation 0.266054320932593 0.578758306357521 1.04560868431085 0.315789473684211 22.3 22 3 thin dermal layer 0.266054320932593 0.578758306357521 1.04560868431085 0.315789473684211 22.3 22 3 delayed sexual maturation 0.266054320932593 0.578758306357521 1.04560868431085 0.315789473684211 22.3 22 3 abnormal neural crest cell migration 0.266054320932593 0.578758306357521 1.04560868431085 0.315789473684211 22.3 22 3 abnormal response to novelty 0.266054320932593 0.578758306357521 1.04560868431085 0.315789473684211 22.3 22 3 abnormal digestive system development 0.266054320932593 0.578758306357521 1.04560868431085 0.315789473684211 22.3 22 3 increased liver adenoma incidence 0.266054320932593 0.578758306357521 1.04560868431085 0.315789473684211 22.3 22 3 osteoarthritis 0.266054320932593 0.578758306357521 1.04560868431085 0.315789473684211 22.3 22 3 decreased circulating magnesium level 0.266054320932593 0.578758306357521 1.04560868431085 0.315789473684211 22.3 22 3 decreased susceptibility to weight gain 0.266054320932593 0.578758306357521 1.04560868431085 0.315789473684211 22.3 22 3 abnormal retina morphology 0.00375984810322011 0.0397138945085351 1.04062959533794 0.314285714285714 22.3 22 3 increased circulating serum albumin level 0.168829103367407 0.507814261942472 1.04062959533794 0.314285714285714 22.3 22 3 holoprosencephaly 0.168829103367407 0.507814261942472 1.04062959533794 0.314285714285714 22.3 22 3 decreased circulating thyroxine level 0.168829103367407 0.507814261942472 1.04062959533794 0.314285714285714 22.3 22 3 decreased bone volume 0.168829103367407 0.507814261942472 1.04062959533794 0.314285714285714 22.3 22 3 abnormal response to novel object 0.113609001961355 0.408662566445574 1.03877464062255 0.313725490196078 22.3 22 3 abnormal femur morphology 0.0786335618507239 0.327639841044683 1.03780563442794 0.313432835820896 22.3 22 3 abnormal crypts of Lieberkuhn morphology 0.189354493470996 0.517256558031924 1.03471692718262 0.3125 22.3 22 3 increased circulating follicle stimulating hormone level 0.189354493470996 0.517256558031924 1.03471692718262 0.3125 22.3 22 3 abnormal depression-related behavior 0.189354493470996 0.517256558031924 1.03471692718262 0.3125 22.3 22 3 decreased susceptibility to parasitic infection 0.189354493470996 0.517256558031924 1.03471692718262 0.3125 22.3 22 3 pancreatic islet hyperplasia 0.189354493470996 0.517256558031924 1.03471692718262 0.3125 22.3 22 3 abnormal tympanic ring morphology 0.305855765821556 0.634807023346784 1.03471692718262 0.3125 22.3 22 3 decreased mast cell number 0.305855765821556 0.634807023346784 1.03471692718262 0.3125 22.3 22 3 delayed hair appearance 0.305855765821556 0.634807023346784 1.03471692718262 0.3125 22.3 22 3 abnormal mouth morphology 0.305855765821556 0.634807023346784 1.03471692718262 0.3125 22.3 22 3 mixed cellular infiltration to dermis 0.305855765821556 0.634807023346784 1.03471692718262 0.3125 22.3 22 3 reduced male mating frequency 0.305855765821556 0.634807023346784 1.03471692718262 0.3125 22.3 22 3 white spotting 0.305855765821556 0.634807023346784 1.03471692718262 0.3125 22.3 22 3 increased pancreatic beta cell number 0.305855765821556 0.634807023346784 1.03471692718262 0.3125 22.3 22 3 decreased aggression towards mice 0.305855765821556 0.634807023346784 1.03471692718262 0.3125 22.3 22 3 increased cochlear outer hair cell number 0.305855765821556 0.634807023346784 1.03471692718262 0.3125 22.3 22 3 abnormal epididymis epithelium morphology 0.305855765821556 0.634807023346784 1.03471692718262 0.3125 22.3 22 3 increased thymus weight 0.305855765821556 0.634807023346784 1.03471692718262 0.3125 22.3 22 3 abnormal level of surface class II molecules 0.305855765821556 0.634807023346784 1.03471692718262 0.3125 22.3 22 3 sepsis 0.305855765821556 0.634807023346784 1.03471692718262 0.3125 22.3 22 3 increased circulating estradiol level 0.305855765821556 0.634807023346784 1.03471692718262 0.3125 22.3 22 3 dystonia 0.305855765821556 0.634807023346784 1.03471692718262 0.3125 22.3 22 3 abnormal Langerhans cell physiology 0.305855765821556 0.634807023346784 1.03471692718262 0.3125 22.3 22 3 loose skin 0.305855765821556 0.634807023346784 1.03471692718262 0.3125 22.3 22 3 impaired behavioral response to addictive substance 0.305855765821556 0.634807023346784 1.03471692718262 0.3125 22.3 22 3 abnormal thoracic cage shape 0.305855765821556 0.634807023346784 1.03471692718262 0.3125 22.3 22 3 obese 0.0670691680175304 0.284700606559056 1.03202935074837 0.311688311688312 22.3 22 3 decreased insulin secretion 0.0521859324501992 0.246006611682694 1.03011818528403 0.311111111111111 22.3 22 3 increased susceptibility to parasitic infection 0.0521859324501992 0.246006611682694 1.03011818528403 0.311111111111111 22.3 22 3 increased circulating corticosterone level 0.1403049699538 0.442996183824695 1.03011818528403 0.311111111111111 22.3 22 3 cochlear ganglion degeneration 0.106188215806662 0.389017948187147 1.02758094837446 0.310344827586207 22.3 22 3 abnormal middle ear morphology 0.213017902705289 0.517256558031924 1.02758094837446 0.310344827586207 22.3 22 3 abnormal circulating glucose level 0.213017902705289 0.517256558031924 1.02758094837446 0.310344827586207 22.3 22 3 decreased retinal photoreceptor cell number 0.213017902705289 0.517256558031924 1.02758094837446 0.310344827586207 22.3 22 3 enlarged epididymis 0.213017902705289 0.517256558031924 1.02758094837446 0.310344827586207 22.3 22 3 abnormal optic nerve morphology 0.156281184488629 0.479050457690038 1.02486248025707 0.30952380952381 22.3 22 3 abnormal reproductive system morphology 0.156281184488629 0.479050457690038 1.02486248025707 0.30952380952381 22.3 22 3 abnormal learning/memory/conditioning 0.117588951579975 0.419960541357053 1.02342910615881 0.309090909090909 22.3 22 3 abnormal leukocyte adhesion 0.174393328809606 0.517256558031924 1.01879820522596 0.307692307692308 22.3 22 3 organ of Corti degeneration 0.144677242600541 0.448108057739933 1.0136002551993 0.306122448979592 22.3 22 3 narrow eye opening 0.19501039460176 0.517256558031924 1.01172321768967 0.305555555555556 22.3 22 3 fragile skeleton 0.272763693647249 0.586703740131981 1.00772431169089 0.304347826086957 22.3 22 3 abnormal innervation pattern to muscle 0.272763693647249 0.586703740131981 1.00772431169089 0.304347826086957 22.3 22 3 blistering 0.272763693647249 0.586703740131981 1.00772431169089 0.304347826086957 22.3 22 3 abnormal circulating insulin level 0.272763693647249 0.586703740131981 1.00772431169089 0.304347826086957 22.3 22 3 pancreas inflammation 0.272763693647249 0.586703740131981 1.00772431169089 0.304347826086957 22.3 22 3 abnormal cochlear ganglion morphology 0.272763693647249 0.586703740131981 1.00772431169089 0.304347826086957 22.3 22 3 abnormal Wolffian duct morphology 0.272763693647249 0.586703740131981 1.00772431169089 0.304347826086957 22.3 22 3 decreased epididymis weight 0.272763693647249 0.586703740131981 1.00772431169089 0.304347826086957 22.3 22 3 abnormal ulna morphology 0.272763693647249 0.586703740131981 1.00772431169089 0.304347826086957 22.3 22 3 abnormal basicranium morphology 0.272763693647249 0.586703740131981 1.00772431169089 0.304347826086957 22.3 22 3 abnormal hepatocyte physiology 0.272763693647249 0.586703740131981 1.00772431169089 0.304347826086957 22.3 22 3 abnormal epidermal layer morphology 0.102033193307921 0.374623717126868 1.00772431169089 0.304347826086957 22.3 22 3 abnormal food intake 0.102033193307921 0.374623717126868 1.00772431169089 0.304347826086957 22.3 22 3 deafness 0.0626322875873398 0.267005681874049 1.00336186878314 0.303030303030303 22.3 22 3 abnormal tail morphology 0.112539702098804 0.405713781117066 1.00336186878314 0.303030303030303 22.3 22 3 increased cardiomyocyte apoptosis 0.218591334100977 0.517256558031924 1.00336186878314 0.303030303030303 22.3 22 3 enlarged kidney 0.148431487552147 0.458662515883188 0.999575597580187 0.30188679245283 22.3 22 3 increased or absent threshold for auditory brainstem response 0.00395511229398221 0.0409078662423316 0.996765372067959 0.301038062283737 22.3 22 3 abnormal gait 0.00299697131238339 0.0338386796467562 0.996542904626363 0.300970873786408 22.3 22 3 abnormal hindlimb morphology 0.164586793422442 0.497158043276652 0.993328250095311 0.3 22.3 22 3 increased body length 0.164586793422442 0.497158043276652 0.993328250095311 0.3 22.3 22 3 decreased respiratory quotient 0.164586793422442 0.497158043276652 0.993328250095311 0.3 22.3 22 3 abnormal pancreatic beta cell morphology 0.199514117944283 0.517256558031924 0.993328250095311 0.3 22.3 22 3 abnormal pericardium morphology 0.311078312760831 0.641897389458786 0.993328250095311 0.3 22.3 22 3 abnormal cell proliferation 0.311078312760831 0.641897389458786 0.993328250095311 0.3 22.3 22 3 small gonad 0.311078312760831 0.641897389458786 0.993328250095311 0.3 22.3 22 3 increased mammary adenocarcinoma incidence 0.311078312760831 0.641897389458786 0.993328250095311 0.3 22.3 22 3 abnormal dopamine level 0.311078312760831 0.641897389458786 0.993328250095311 0.3 22.3 22 3 abnormal hearing physiology 0.311078312760831 0.641897389458786 0.993328250095311 0.3 22.3 22 3 abnormal hair texture 0.311078312760831 0.641897389458786 0.993328250095311 0.3 22.3 22 3 abnormal trachea morphology 0.311078312760831 0.641897389458786 0.993328250095311 0.3 22.3 22 3 abnormal hyoid bone morphology 0.311078312760831 0.641897389458786 0.993328250095311 0.3 22.3 22 3 abnormal male reproductive system physiology 0.311078312760831 0.641897389458786 0.993328250095311 0.3 22.3 22 3 decreased circulating VLDL cholesterol level 0.311078312760831 0.641897389458786 0.993328250095311 0.3 22.3 22 3 dehydration 0.115224280483325 0.413153468867307 0.993328250095311 0.3 22.3 22 3 abnormal hair cycle 0.245716785105085 0.542583668840568 0.993328250095311 0.3 22.3 22 3 maternal effect 0.126967846885221 0.438828735119033 0.988386318502797 0.298507462686567 22.3 22 3 decreased brain weight 0.151663415892696 0.467198448338181 0.987519312960251 0.298245614035088 22.3 22 3 impaired natural killer cell mediated cytotoxicity 0.151663415892696 0.467198448338181 0.987519312960251 0.298245614035088 22.3 22 3 abnormal innervation 0.182718909837596 0.517256558031924 0.986283368888961 0.297872340425532 22.3 22 3 abnormal T-helper 1 physiology 0.182718909837596 0.517256558031924 0.986283368888961 0.297872340425532 22.3 22 3 increased white adipose tissue amount 0.22285547294795 0.517256558031924 0.984379346941299 0.297297297297297 22.3 22 3 impaired skeletal muscle contractility 0.22285547294795 0.517256558031924 0.984379346941299 0.297297297297297 22.3 22 3 decreased eosinophil cell number 0.139991779935386 0.442996183824695 0.982981080823485 0.296875 22.3 22 3 abnormal mandible morphology 0.167799072522263 0.50593962775652 0.981064938365739 0.296296296296296 22.3 22 3 polyphagia 0.167799072522263 0.50593962775652 0.981064938365739 0.296296296296296 22.3 22 3 abnormal long bone epiphyseal plate proliferative zone 0.167799072522263 0.50593962775652 0.981064938365739 0.296296296296296 22.3 22 3 increased brain weight 0.277136440062343 0.586703740131981 0.981064938365739 0.296296296296296 22.3 22 3 abnormal palate morphology 0.277136440062343 0.586703740131981 0.981064938365739 0.296296296296296 22.3 22 3 abnormal skin appearance 0.277136440062343 0.586703740131981 0.981064938365739 0.296296296296296 22.3 22 3 abnormal motor capabilities/coordination/movement 0.0545383980891091 0.246865191189718 0.978277822063564 0.295454545454545 22.3 22 3 short femur 0.10126161343852 0.373721459092461 0.978277822063564 0.295454545454545 22.3 22 3 abnormal NK cell physiology 0.154450313796538 0.474022400455136 0.977044180421617 0.295081967213115 22.3 22 3 decreased susceptibility to injury 0.142438282407875 0.443988922661253 0.973851225583638 0.294117647058824 22.3 22 3 abnormal oocyte morphology 0.24946984088772 0.549894753396725 0.973851225583638 0.294117647058824 22.3 22 3 abnormal vision 0.24946984088772 0.549894753396725 0.973851225583638 0.294117647058824 22.3 22 3 decreased cytotoxic T cell cytolysis 0.24946984088772 0.549894753396725 0.973851225583638 0.294117647058824 22.3 22 3 increased susceptibility to viral infection induced morbidity/mortality 0.24946984088772 0.549894753396725 0.973851225583638 0.294117647058824 22.3 22 3 abnormal adipose tissue morphology 0.357358606572162 0.690967379594445 0.973851225583638 0.294117647058824 22.3 22 3 distended urinary bladder 0.357358606572162 0.690967379594445 0.973851225583638 0.294117647058824 22.3 22 3 increased regulatory T cell number 0.357358606572162 0.690967379594445 0.973851225583638 0.294117647058824 22.3 22 3 abnormal ectoplacental cone morphology 0.357358606572162 0.690967379594445 0.973851225583638 0.294117647058824 22.3 22 3 increased circulating magnesium level 0.357358606572162 0.690967379594445 0.973851225583638 0.294117647058824 22.3 22 3 abnormal circulating chemokine level 0.357358606572162 0.690967379594445 0.973851225583638 0.294117647058824 22.3 22 3 impaired balance 0.0874663990659671 0.339095593914765 0.973851225583638 0.294117647058824 22.3 22 3 increased kidney weight 0.185827539864561 0.517256558031924 0.973851225583638 0.294117647058824 22.3 22 3 scaly skin 0.226129010083722 0.517256558031924 0.969100731800303 0.292682926829268 22.3 22 3 apnea 0.313842395216194 0.647064200663309 0.965735798703774 0.291666666666667 22.3 22 3 blindness 0.313842395216194 0.647064200663309 0.965735798703774 0.291666666666667 22.3 22 3 decreased food intake 0.133500813340927 0.438828735119033 0.963989441020766 0.291139240506329 22.3 22 3 decreased startle reflex 0.0838167565615177 0.336109828065709 0.962198304935629 0.290598290598291 22.3 22 3 abnormal retinal photoreceptor layer morphology 0.279965916262503 0.592441698598874 0.961285403318043 0.290322580645161 22.3 22 3 decreased hair follicle number 0.252165131888612 0.554852512669547 0.958474627284949 0.289473684210526 22.3 22 3 increased grooming behavior 0.252165131888612 0.554852512669547 0.958474627284949 0.289473684210526 22.3 22 3 abnormal compact bone morphology 0.252165131888612 0.554852512669547 0.958474627284949 0.289473684210526 22.3 22 3 decreased threshold for auditory brainstem response 0.252165131888612 0.554852512669547 0.958474627284949 0.289473684210526 22.3 22 3 absent corpus luteum 0.208316799879156 0.517256558031924 0.955123317399337 0.288461538461538 22.3 22 3 abnormal female meiosis 0.208316799879156 0.517256558031924 0.955123317399337 0.288461538461538 22.3 22 3 increased percent body fat/body weight 0.208316799879156 0.517256558031924 0.955123317399337 0.288461538461538 22.3 22 3 abnormal nervous system electrophysiology 0.149536723161238 0.461790935895194 0.946026904852677 0.285714285714286 22.3 22 3 small ears 0.357187710715808 0.690967379594445 0.946026904852677 0.285714285714286 22.3 22 3 abnormal eye pigmentation 0.357187710715808 0.690967379594445 0.946026904852677 0.285714285714286 22.3 22 3 increased incidence of induced tumors 0.357187710715808 0.690967379594445 0.946026904852677 0.285714285714286 22.3 22 3 abnormal associative learning 0.357187710715808 0.690967379594445 0.946026904852677 0.285714285714286 22.3 22 3 increased acute inflammation 0.357187710715808 0.690967379594445 0.946026904852677 0.285714285714286 22.3 22 3 abnormal bile salt homeostasis 0.357187710715808 0.690967379594445 0.946026904852677 0.285714285714286 22.3 22 3 abnormal epidermis stratum corneum morphology 0.230537972593142 0.517256558031924 0.946026904852677 0.285714285714286 22.3 22 3 impaired adaptive thermogenesis 0.281726135895846 0.595659807089602 0.946026904852677 0.285714285714286 22.3 22 3 abnormal respiration 0.315114683398117 0.648075878423164 0.946026904852677 0.285714285714286 22.3 22 3 abnormal hormone level 0.315114683398117 0.648075878423164 0.946026904852677 0.285714285714286 22.3 22 3 decreased circulating progesterone level 0.315114683398117 0.648075878423164 0.946026904852677 0.285714285714286 22.3 22 3 abnormal inner ear morphology 0.255363956845415 0.558627694120782 0.935744003712974 0.282608695652174 22.3 22 3 acanthosis 0.28271834024108 0.597503713975944 0.933898354790463 0.282051282051282 22.3 22 3 atelectasis 0.194844593854775 0.517256558031924 0.932702582249118 0.28169014084507 22.3 22 3 abnormal circulating amino acid level 0.232980315826335 0.51916688786277 0.929429941609648 0.280701754385965 22.3 22 3 increased pre-B cell number 0.355911509530931 0.690967379594445 0.927106366755623 0.28 22.3 22 3 abnormal feces composition 0.355911509530931 0.690967379594445 0.927106366755623 0.28 22.3 22 3 increased liver glycogen level 0.355911509530931 0.690967379594445 0.927106366755623 0.28 22.3 22 3 abnormal intestinal mucosa morphology 0.283143304703156 0.598147745604331 0.924026279158428 0.27906976744186 22.3 22 3 abnormal systemic arterial blood pressure 0.315078344085879 0.648075878423164 0.91974837971788 0.277777777777778 22.3 22 3 right pulmonary isomerism 0.409088120533104 0.716665102466787 0.91974837971788 0.277777777777778 22.3 22 3 abnormal retinal rod cell morphology 0.409088120533104 0.716665102466787 0.91974837971788 0.277777777777778 22.3 22 3 abnormal iron level 0.409088120533104 0.716665102466787 0.91974837971788 0.277777777777778 22.3 22 3 abnormal thyroid cartilage morphology 0.409088120533104 0.716665102466787 0.91974837971788 0.277777777777778 22.3 22 3 acidosis 0.409088120533104 0.716665102466787 0.91974837971788 0.277777777777778 22.3 22 3 abnormal neutrophil morphology 0.409088120533104 0.716665102466787 0.91974837971788 0.277777777777778 22.3 22 3 abnormal anterior eye segment morphology 0.409088120533104 0.716665102466787 0.91974837971788 0.277777777777778 22.3 22 3 decreased granulocyte number 0.354008695090624 0.690967379594445 0.913405287443964 0.275862068965517 22.3 22 3 abnormal outer ear morphology 0.354008695090624 0.690967379594445 0.913405287443964 0.275862068965517 22.3 22 3 increased retinal apoptosis 0.354008695090624 0.690967379594445 0.913405287443964 0.275862068965517 22.3 22 3 abnormal female reproductive system morphology 0.314278562491589 0.647426852337745 0.910550895920701 0.275 22.3 22 3 impaired ovarian folliculogenesis 0.314278562491589 0.647426852337745 0.910550895920701 0.275 22.3 22 3 increased thermal nociceptive threshold 0.197650478168716 0.517256558031924 0.909641254666036 0.274725274725275 22.3 22 3 impaired swimming 0.256371224061834 0.560143539616876 0.903025681904828 0.272727272727273 22.3 22 3 decreased systemic arterial blood pressure 0.351734269661984 0.688386306675205 0.903025681904828 0.272727272727273 22.3 22 3 abnormal oogenesis 0.403670439341776 0.716665102466787 0.903025681904828 0.272727272727273 22.3 22 3 increased myocardial infarction size 0.403670439341776 0.716665102466787 0.903025681904828 0.272727272727273 22.3 22 3 parakeratosis 0.403670439341776 0.716665102466787 0.903025681904828 0.272727272727273 22.3 22 3 decreased circulating estradiol level 0.403670439341776 0.716665102466787 0.903025681904828 0.272727272727273 22.3 22 3 abnormal temporal bone morphology 0.403670439341776 0.716665102466787 0.903025681904828 0.272727272727273 22.3 22 3 abnormal cerebral cortex pyramidal cell morphology 0.403670439341776 0.716665102466787 0.903025681904828 0.272727272727273 22.3 22 3 syndactyly 0.281428006457575 0.595282454135389 0.897923841894066 0.271186440677966 22.3 22 3 abnormal urine homeostasis 0.214485617744256 0.517256558031924 0.896754670224933 0.270833333333333 22.3 22 3 abnormal hair growth 0.310251636848928 0.641897389458786 0.891448429572715 0.269230769230769 22.3 22 3 abnormal kidney cortex morphology 0.398427649946996 0.716665102466787 0.891448429572715 0.269230769230769 22.3 22 3 small seminal vesicle 0.398427649946996 0.716665102466787 0.891448429572715 0.269230769230769 22.3 22 3 abnormal excitatory postsynaptic currents 0.254575576484819 0.558627694120782 0.891448429572715 0.269230769230769 22.3 22 3 abnormal eye development 0.30858386426512 0.639935274997488 0.886900223299384 0.267857142857143 22.3 22 3 abnormal eye physiology 0.30681960186672 0.636541917967862 0.882958444529165 0.266666666666667 22.3 22 3 abnormal estrous cycle 0.393387571449001 0.716665102466787 0.882958444529165 0.266666666666667 22.3 22 3 abnormal synaptic transmission 0.393387571449001 0.716665102466787 0.882958444529165 0.266666666666667 22.3 22 3 abnormal bone remodeling 0.388549464020719 0.716665102466787 0.876466103025274 0.264705882352941 22.3 22 3 abnormal nervous system development 0.388549464020719 0.716665102466787 0.876466103025274 0.264705882352941 22.3 22 3 abnormal eye electrophysiology 0.226841910654075 0.517256558031924 0.875661267301651 0.264462809917355 22.3 22 3 abnormal pancreatic islet morphology 0.338357856605504 0.674141103969717 0.874628647882664 0.264150943396226 22.3 22 3 abnormal blood homeostasis 0.245136719547164 0.541543152640826 0.871340570259045 0.263157894736842 22.3 22 3 abnormal reproductive system physiology 0.38390275986058 0.716665102466787 0.871340570259044 0.263157894736842 22.3 22 3 decreased grooming behavior 0.460171620390428 0.775789160095689 0.871340570259044 0.263157894736842 22.3 22 3 increased malignant tumor incidence 0.460171620390428 0.775789160095689 0.871340570259044 0.263157894736842 22.3 22 3 abnormal metatarsal bone morphology 0.460171620390428 0.775789160095689 0.871340570259044 0.263157894736842 22.3 22 3 abnormal optic vesicle formation 0.460171620390428 0.775789160095689 0.871340570259044 0.263157894736842 22.3 22 3 abnormal cochlear inner hair cell morphology 0.460171620390428 0.775789160095689 0.871340570259044 0.263157894736842 22.3 22 3 eyelids fail to open 0.460171620390428 0.775789160095689 0.871340570259044 0.263157894736842 22.3 22 3 right-sided stomach 0.460171620390428 0.775789160095689 0.871340570259044 0.263157894736842 22.3 22 3 abnormal CNS synaptic transmission 0.26830547829097 0.58340024235034 0.869580286278723 0.262626262626263 22.3 22 3 abnormal social investigation 0.297245807927777 0.622127847892591 0.869162218833397 0.2625 22.3 22 3 abnormal forelimb morphology 0.375129380457561 0.716665102466787 0.863763695735053 0.260869565217391 22.3 22 3 abnormal sleep pattern 0.375129380457561 0.716665102466787 0.863763695735053 0.260869565217391 22.3 22 3 abnormal cardiovascular development 0.449872820175139 0.760230054473952 0.863763695735053 0.260869565217391 22.3 22 3 abnormal lens development 0.449872820175139 0.760230054473952 0.863763695735053 0.260869565217391 22.3 22 3 diluted coat color 0.366962123455402 0.709260514448573 0.858431821070022 0.259259259259259 22.3 22 3 decreased susceptibility to pharmacologically induced seizures 0.440879573406625 0.745792545970065 0.858431821070022 0.259259259259259 22.3 22 3 increased lung adenoma incidence 0.432838581948652 0.732688650967861 0.854475914060482 0.258064516129032 22.3 22 3 abnormal postnatal growth/weight/body size 0.432838581948652 0.732688650967861 0.854475914060482 0.258064516129032 22.3 22 3 thick epidermis 0.352104102034461 0.688839130012365 0.851424214367409 0.257142857142857 22.3 22 3 abnormal organ of Corti morphology 0.412533891318883 0.716665102466787 0.84702408922856 0.255813953488372 22.3 22 3 increased systemic arterial blood pressure 0.406668595163894 0.716665102466787 0.845385744761967 0.25531914893617 22.3 22 3 decreased bone trabecula number 0.406668595163894 0.716665102466787 0.845385744761967 0.25531914893617 22.3 22 3 abnormal cued conditioning behavior 0.401138908577042 0.716665102466787 0.844004395505819 0.254901960784314 22.3 22 3 abnormal brain wave pattern 0.431434665819747 0.730809486705223 0.827773541746092 0.25 22.3 22 3 decreased body temperature 0.431434665819747 0.730809486705223 0.827773541746092 0.25 22.3 22 3 abnormal uterus morphology 0.462342911851505 0.778921769881896 0.827773541746092 0.25 22.3 22 3 short radius 0.462342911851505 0.778921769881896 0.827773541746092 0.25 22.3 22 3 neonatal lethality 0.471977255943694 0.793693244131462 0.827773541746092 0.25 22.3 22 3 abnormal serotonin level 0.471977255943694 0.793693244131462 0.827773541746092 0.25 22.3 22 3 increased urine glucose level 0.509869389600294 0.837714733573798 0.827773541746092 0.25 22.3 22 3 decreased paired-pulse facilitation 0.509869389600294 0.837714733573798 0.827773541746092 0.25 22.3 22 3 abnormal incus morphology 0.509869389600294 0.837714733573798 0.827773541746092 0.25 22.3 22 3 abnormal response to tactile stimuli 0.509869389600294 0.837714733573798 0.827773541746092 0.25 22.3 22 3 abnormal circulating cytokine level 0.509869389600294 0.837714733573798 0.827773541746092 0.25 22.3 22 3 nuclear cataracts 0.509869389600294 0.837714733573798 0.827773541746092 0.25 22.3 22 3 increased susceptibility to pharmacologically induced seizures 0.375360895712473 0.716665102466787 0.827773541746092 0.25 22.3 22 3 cochlear hair cell degeneration 0.445660926486097 0.753624442307386 0.827773541746092 0.25 22.3 22 3 abnormal stria vascularis morphology 0.482801203409462 0.810916943606371 0.827773541746092 0.25 22.3 22 3 increased stereotypic behavior 0.495216295161454 0.825913868061761 0.827773541746092 0.25 22.3 22 3 abnormal startle reflex 0.495216295161454 0.825913868061761 0.827773541746092 0.25 22.3 22 3 hyperkeratosis 0.434025611075981 0.734448100375172 0.815776823749772 0.246376811594203 22.3 22 3 short humerus 0.488158956872307 0.814689973310878 0.807583943166919 0.24390243902439 22.3 22 3 abnormal humerus morphology 0.49869903825975 0.831443604337218 0.805401283861063 0.243243243243243 22.3 22 3 dextrocardia 0.510455011553841 0.838123327551274 0.802689495026514 0.242424242424242 22.3 22 3 head tossing 0.510455011553841 0.838123327551274 0.802689495026514 0.242424242424242 22.3 22 3 abnormal microglial cell morphology 0.523780637874546 0.841405582498843 0.799229626513468 0.241379310344828 22.3 22 3 stomach inflammation 0.523780637874546 0.841405582498843 0.799229626513468 0.241379310344828 22.3 22 3 abnormal inner ear vestibule morphology 0.539207280097409 0.841405582498843 0.794662600076249 0.24 22.3 22 3 mandible hypoplasia 0.539207280097409 0.841405582498843 0.794662600076249 0.24 22.3 22 3 abnormal energy expenditure 0.539207280097409 0.841405582498843 0.794662600076249 0.24 22.3 22 3 abnormal stomach mucosa morphology 0.539207280097409 0.841405582498843 0.794662600076249 0.24 22.3 22 3 delayed wound healing 0.511103612554932 0.838911406288614 0.791783387757132 0.239130434782609 22.3 22 3 abnormal scapula morphology 0.557582414251696 0.851957159367993 0.788355754043897 0.238095238095238 22.3 22 3 abnormal salivary gland morphology 0.557582414251696 0.851957159367993 0.788355754043897 0.238095238095238 22.3 22 3 increased vasoconstriction 0.557582414251696 0.851957159367993 0.788355754043897 0.238095238095238 22.3 22 3 hypoalgesia 0.557582414251696 0.851957159367993 0.788355754043897 0.238095238095238 22.3 22 3 increased keratinocyte proliferation 0.557582414251696 0.851957159367993 0.788355754043897 0.238095238095238 22.3 22 3 cochlear inner hair cell degeneration 0.531749597781846 0.841405582498843 0.77908098046691 0.235294117647059 22.3 22 3 abnormal tibia morphology 0.543014312313304 0.841405582498843 0.774936932698469 0.234042553191489 22.3 22 3 abnormal pain threshold 0.563465484177974 0.860681849488922 0.772588638963019 0.233333333333333 22.3 22 3 abnormal male reproductive system morphology 0.555348127035941 0.849848333437037 0.77002189929869 0.232558139534884 22.3 22 3 impaired righting response 0.543371350565533 0.841405582498843 0.766779701827959 0.231578947368421 22.3 22 3 decreased trabecular bone volume 0.568984928621287 0.868845923846195 0.76409865391947 0.230769230769231 22.3 22 3 abnormal hair shaft morphology 0.574147107791713 0.876459607629265 0.758792413267251 0.229166666666667 22.3 22 3 abnormal gametogenesis 0.58760906837413 0.883990055990716 0.752521401587357 0.227272727272727 22.3 22 3 intestinal ulcer 0.602850642166377 0.904457763805105 0.752521401587357 0.227272727272727 22.3 22 3 testis hypoplasia 0.602850642166377 0.904457763805105 0.752521401587357 0.227272727272727 22.3 22 3 abnormal tracheal cartilage morphology 0.602850642166377 0.904457763805105 0.752521401587357 0.227272727272727 22.3 22 3 decreased cardiac output 0.602850642166377 0.904457763805105 0.752521401587357 0.227272727272727 22.3 22 3 abnormal retinal outer plexiform layer morphology 0.602850642166377 0.904457763805105 0.752521401587357 0.227272727272727 22.3 22 3 failure of palatal shelf elevation 0.602850642166377 0.904457763805105 0.752521401587357 0.227272727272727 22.3 22 3 abnormal nose morphology 0.601564997328192 0.904438157058856 0.747666424802922 0.225806451612903 22.3 22 3 abnormal intestine physiology 0.601564997328192 0.904438157058856 0.747666424802922 0.225806451612903 22.3 22 3 abnormal skin pigmentation 0.602474373027407 0.904457763805105 0.744996187571483 0.225 22.3 22 3 abnormal epidermis stratum granulosum morphology 0.619070607020392 0.925165596253064 0.735798703774304 0.222222222222222 22.3 22 3 head tilt 0.619070607020392 0.925165596253064 0.735798703774304 0.222222222222222 22.3 22 3 abnormal locomotor activation 0.64832676137222 0.92760990699712 0.727713003732828 0.21978021978022 22.3 22 3 arrested B cell differentiation 0.634625583821029 0.92760990699712 0.726825548850227 0.219512195121951 22.3 22 3 increased dopamine level 0.637849564915851 0.92760990699712 0.724301849027831 0.21875 22.3 22 3 abnormal long term potentiation 0.637849564915851 0.92760990699712 0.724301849027831 0.21875 22.3 22 3 abnormal regulatory T cell physiology 0.645344481608388 0.92760990699712 0.719803079779211 0.217391304347826 22.3 22 3 abnormal pancreas morphology 0.665304693750814 0.938976128059659 0.709520178639508 0.214285714285714 22.3 22 3 abnormal vibrissa morphology 0.665304693750814 0.938976128059659 0.709520178639508 0.214285714285714 22.3 22 3 reddish skin 0.659456285519155 0.934699436027862 0.709520178639508 0.214285714285714 22.3 22 3 short mandible 0.673280772672058 0.949694313593277 0.709520178639508 0.214285714285714 22.3 22 3 abnormal middle ear ossicle morphology 0.672148098513316 0.948365510522901 0.7023533081482 0.212121212121212 22.3 22 3 circling 0.710292591824199 0.993199971535246 0.701172882420219 0.211764705882353 22.3 22 3 abnormal axon guidance 0.694410843763575 0.977006206935459 0.693019709368821 0.209302325581395 22.3 22 3 abnormal malleus morphology 0.684851899094423 0.963829758980129 0.68981128478841 0.208333333333333 22.3 22 3 abnormal digestive system morphology 0.684851899094423 0.963829758980129 0.68981128478841 0.208333333333333 22.3 22 3 decreased fatty acid level 0.684851899094423 0.963829758980129 0.68981128478841 0.208333333333333 22.3 22 3 absent long term depression 0.694849932730792 0.977347587032991 0.685053965582973 0.206896551724138 22.3 22 3 thin skin 0.704343869403302 0.990421353951788 0.681695857908546 0.205882352941176 22.3 22 3 abnormal photoreceptor outer segment morphology 0.721874157435145 0.99713957179253 0.677269261428621 0.204545454545455 22.3 22 3 abnormal cartilage development 0.747653213053265 1 0.662218833396874 0.2 22.3 22 3 abnormal autopod morphology 0.747653213053265 1 0.662218833396874 0.2 22.3 22 3 abnormal ovarian follicle morphology 0.747653213053265 1 0.662218833396874 0.2 22.3 22 3 impaired conditioned place preference behavior 0.721263053843677 0.99713957179253 0.662218833396874 0.2 22.3 22 3 abnormal digestive system physiology 0.754096616650614 1 0.662218833396874 0.2 22.3 22 3 decreased oocyte number 0.754096616650614 1 0.662218833396874 0.2 22.3 22 3 arrested T cell differentiation 0.727696044868996 0.99713957179253 0.662218833396874 0.2 22.3 22 3 abnormal limb bone morphology 0.762199993143451 1 0.643823865802516 0.194444444444444 22.3 22 3 abnormal single cell response 0.784770422796485 1 0.613165586478587 0.185185185185185 22.3 22 3 enhanced long term potentiation 0.867411953094654 1 0.591266815532923 0.178571428571429 22.3 22 3 enhanced coordination 0.812012626552426 1 0.591266815532923 0.178571428571429 22.3 22 3 abnormal inhibitory postsynaptic currents 0.893493035411906 1 0.584310735350183 0.176470588235294 22.3 22 3 head bobbing 0.852261236710512 1 0.579441479222265 0.175 22.3 22 3 focal hair loss 0.8364215210986 1 0.570878304652477 0.172413793103448 22.3 22 3 impaired behavioral response to xenobiotic 0.854317780469008 1 0.567616142911606 0.171428571428571 22.3 22 3 short ulna 0.869843699274373 1 0.565308760216844 0.170731707317073 22.3 22 3 abnormal body temperature homeostasis 0.877435677895623 1 0.534047446287801 0.161290322580645 22.3 22 3 abnormal phalanx morphology 0.950241145927675 1 0.482867899351887 0.145833333333333 22.3 22 3 abnormal reflex 0.943545947707785 1 0.45987418985894 0.138888888888889 22.3 22 3 abnormal soft palate morphology 6.54219591796084e-05 0.000704266496633399 2.33372641509434 1 23.1 23 1 decreased vascular endothelial cell proliferation 6.54219591796084e-05 0.000704266496633399 2.33372641509434 1 23.1 23 1 decreased collagen level 0.000218204011160859 0.00199919881312205 2.33372641509434 1 23.1 23 1 absent radius 0.000727732905659196 0.00552743695519771 2.33372641509434 1 23.1 23 1 non-obstructive hydrocephaly 0.000727732905659196 0.00552743695519771 2.33372641509434 1 23.1 23 1 abnormal lambdoidal suture morphology 0.000727732905659196 0.00552743695519771 2.33372641509434 1 23.1 23 1 osteomyelitis 0.000727732905659196 0.00552743695519771 2.33372641509434 1 23.1 23 1 abnormal aorta tunica adventitia morphology 0.000727732905659196 0.00552743695519771 2.33372641509434 1 23.1 23 1 abnormal olfactory bulb layer morphology 0.000727732905659196 0.00552743695519771 2.33372641509434 1 23.1 23 1 abnormal orbit morphology 0.000727732905659196 0.00552743695519771 2.33372641509434 1 23.1 23 1 thymus cortex atrophy 0.000727732905659196 0.00552743695519771 2.33372641509434 1 23.1 23 1 additional anastomosis between intracranial vertebral arteries 0.000727732905659196 0.00552743695519771 2.33372641509434 1 23.1 23 1 kidney vascular congestion 0.00242689729889433 0.0145117957475953 2.33372641509434 1 23.1 23 1 abnormal pineal gland morphology 0.00242689729889433 0.0145117957475953 2.33372641509434 1 23.1 23 1 failure of neuromuscular synapse presynaptic differentiation 0.00242689729889433 0.0145117957475953 2.33372641509434 1 23.1 23 1 vascular inflammation 0.00242689729889433 0.0145117957475953 2.33372641509434 1 23.1 23 1 abnormal type I pneumocyte morphology 0.00242689729889433 0.0145117957475953 2.33372641509434 1 23.1 23 1 abnormal lung compliance 0.00242689729889433 0.0145117957475953 2.33372641509434 1 23.1 23 1 abnormal hypodermis morphology 0.00242689729889433 0.0145117957475953 2.33372641509434 1 23.1 23 1 increased heart right ventricle weight 0.00242689729889433 0.0145117957475953 2.33372641509434 1 23.1 23 1 enlarged eye anterior chamber 0.00242689729889433 0.0145117957475953 2.33372641509434 1 23.1 23 1 abnormal cranium size 0.00242689729889433 0.0145117957475953 2.33372641509434 1 23.1 23 1 increased mammary gland epithelial cell proliferation 0.00242689729889433 0.0145117957475953 2.33372641509434 1 23.1 23 1 increased T follicular helper cell number 0.00242689729889433 0.0145117957475953 2.33372641509434 1 23.1 23 1 abnormal heart ventricle outflow tract morphology 0.00242689729889433 0.0145117957475953 2.33372641509434 1 23.1 23 1 inlet ventricular septal defect 0.00242689729889433 0.0145117957475953 2.33372641509434 1 23.1 23 1 alveolitis 0.00242689729889433 0.0145117957475953 2.33372641509434 1 23.1 23 1 fused right lung lobes 0.00242689729889433 0.0145117957475953 2.33372641509434 1 23.1 23 1 abnormal sagittal suture morphology 1.59981624078476e-06 2.60887134635902e-05 2.16703167115903 0.928571428571429 23.1 23 1 hematuria 1.53387469552505e-05 0.000192702692177706 2.13924921383648 0.916666666666667 23.1 23 1 prenatal growth retardation 1.53387469552505e-05 0.000192702692177706 2.13924921383648 0.916666666666667 23.1 23 1 abnormal sphenoid bone morphology 4.70518479611935e-05 0.0005210601206665 2.12156946826758 0.909090909090909 23.1 23 1 decreased atrioventricular cushion size 4.70518479611935e-05 0.0005210601206665 2.12156946826758 0.909090909090909 23.1 23 1 common atrioventricular valve 4.70518479611935e-05 0.0005210601206665 2.12156946826758 0.909090909090909 23.1 23 1 increased cranium width 0.000143217374076392 0.00137815558226315 2.10035377358491 0.9 23.1 23 1 bifid ureter 0.000143217374076392 0.00137815558226315 2.10035377358491 0.9 23.1 23 1 increased heart rate variability 0.000143217374076392 0.00137815558226315 2.10035377358491 0.9 23.1 23 1 abnormal heart and great artery attachment 0.000143217374076392 0.00137815558226315 2.10035377358491 0.9 23.1 23 1 decreased circulating lactate level 0.000143217374076392 0.00137815558226315 2.10035377358491 0.9 23.1 23 1 adipose tissue inflammation 0.000431889864969758 0.00362947986186578 2.07442348008386 0.888888888888889 23.1 23 1 abnormal adipose tissue morphology 1.00058142286659e-06 1.76521013431251e-05 2.05917036625971 0.882352941176471 23.1 23 1 hydroureter 1.00058142286659e-06 1.76521013431251e-05 2.05917036625971 0.882352941176471 23.1 23 1 abnormal pulmonary elastic fiber morphology 2.95637429234781e-06 4.44349308290948e-05 2.04201061320755 0.875 23.1 23 1 failure of vascular branching 0.00128767837502961 0.00893472791600045 2.04201061320755 0.875 23.1 23 1 absent eyelids 0.00128767837502961 0.00893472791600045 2.04201061320755 0.875 23.1 23 1 short ureter 0.00128767837502961 0.00893472791600045 2.04201061320755 0.875 23.1 23 1 absent tympanic ring 0.00128767837502961 0.00893472791600045 2.04201061320755 0.875 23.1 23 1 liver cysts 0.00128767837502961 0.00893472791600045 2.04201061320755 0.875 23.1 23 1 increased cardiac output 0.00128767837502961 0.00893472791600045 2.04201061320755 0.875 23.1 23 1 craniofacial phenotype 0.00128767837502961 0.00893472791600045 2.04201061320755 0.875 23.1 23 1 skin fibrosis 0.00128767837502961 0.00893472791600045 2.04201061320755 0.875 23.1 23 1 abnormal olfactory bulb mitral cell layer morphology 0.00128767837502961 0.00893472791600045 2.04201061320755 0.875 23.1 23 1 abnormal hepatic vein morphology 0.00128767837502961 0.00893472791600045 2.04201061320755 0.875 23.1 23 1 myocardial trabeculae hypoplasia 0.00128767837502961 0.00893472791600045 2.04201061320755 0.875 23.1 23 1 abnormal foramen magnum morphology 0.00128767837502961 0.00893472791600045 2.04201061320755 0.875 23.1 23 1 increased aorta wall thickness 0.00128767837502961 0.00893472791600045 2.04201061320755 0.875 23.1 23 1 decreased cranium length 0.00128767837502961 0.00893472791600045 2.04201061320755 0.875 23.1 23 1 abnormal umbilical vein topology 0.00128767837502961 0.00893472791600045 2.04201061320755 0.875 23.1 23 1 abnormal cricoid cartilage morphology 8.66604629284702e-06 0.000115896721255145 2.02256289308176 0.866666666666667 23.1 23 1 abnormal aorta wall morphology 8.66604629284702e-06 0.000115896721255145 2.02256289308176 0.866666666666667 23.1 23 1 abnormal ventral body wall morphology 2.51747730555655e-05 0.000299627980745068 2.00033692722372 0.857142857142857 23.1 23 1 abnormal gastrulation movements 0.00378490627264921 0.0215939320027865 2.00033692722372 0.857142857142857 23.1 23 1 aorta coarctation 0.00378490627264921 0.0215939320027865 2.00033692722372 0.857142857142857 23.1 23 1 abnormal spinal cord central canal morphology 0.00378490627264921 0.0215939320027865 2.00033692722372 0.857142857142857 23.1 23 1 decreased brain cholesterol level 0.00378490627264921 0.0215939320027865 2.00033692722372 0.857142857142857 23.1 23 1 decreased skeletal muscle glycogen level 0.00378490627264921 0.0215939320027865 2.00033692722372 0.857142857142857 23.1 23 1 abnormal aortic valve cusp morphology 0.00378490627264921 0.0215939320027865 2.00033692722372 0.857142857142857 23.1 23 1 thick mitral valve cusps 0.00378490627264921 0.0215939320027865 2.00033692722372 0.857142857142857 23.1 23 1 altered tumor pathology 0.00378490627264921 0.0215939320027865 2.00033692722372 0.857142857142857 23.1 23 1 small lung lobe 0.00378490627264921 0.0215939320027865 2.00033692722372 0.857142857142857 23.1 23 1 abnormal Mullerian duct topology 0.00378490627264921 0.0215939320027865 2.00033692722372 0.857142857142857 23.1 23 1 absent ductus venosus valve 5.3736069799905e-07 1.01263995172169e-05 1.98366745283019 0.85 23.1 23 1 abnormal xiphoid process morphology 1.19580853302015e-08 3.32354606244428e-07 1.9746915820029 0.846153846153846 23.1 23 1 absent hypoglossal nerve 7.23796855303418e-05 0.000769420802379168 1.9746915820029 0.846153846153846 23.1 23 1 increased malignant tumor incidence 1.53075927286213e-06 2.51337537375878e-05 1.96524329692155 0.842105263157895 23.1 23 1 abnormal mitral valve morphology 4.32212801967904e-06 6.23263388345021e-05 1.94477201257862 0.833333333333333 23.1 23 1 abnormal body wall morphology 4.32212801967904e-06 6.23263388345021e-05 1.94477201257862 0.833333333333333 23.1 23 1 mesocardia 0.000205617352990908 0.00188735485448296 1.94477201257862 0.833333333333333 23.1 23 1 abnormal mating frequency 0.000205617352990908 0.00188735485448296 1.94477201257862 0.833333333333333 23.1 23 1 abnormal aorta elastic fiber morphology 0.000205617352990908 0.00188735485448296 1.94477201257862 0.833333333333333 23.1 23 1 abnormal rostral-caudal body axis extension 0.000205617352990908 0.00188735485448296 1.94477201257862 0.833333333333333 23.1 23 1 abnormal aorta elastic tissue morphology 0.000205617352990908 0.00188735485448296 1.94477201257862 0.833333333333333 23.1 23 1 abnormal pulmonary valve cusp morphology 0.000205617352990908 0.00188735485448296 1.94477201257862 0.833333333333333 23.1 23 1 poor arterial differentiation 0.01092271926507 0.0494282247386805 1.94477201257862 0.833333333333333 23.1 23 1 left-sided isomerism 0.01092271926507 0.0494282247386805 1.94477201257862 0.833333333333333 23.1 23 1 abnormal lacrimal gland physiology 0.01092271926507 0.0494282247386805 1.94477201257862 0.833333333333333 23.1 23 1 abnormal hippocampal fimbria morphology 0.01092271926507 0.0494282247386805 1.94477201257862 0.833333333333333 23.1 23 1 calcified joint 0.01092271926507 0.0494282247386805 1.94477201257862 0.833333333333333 23.1 23 1 enlarged pancreas 0.01092271926507 0.0494282247386805 1.94477201257862 0.833333333333333 23.1 23 1 abnormal periodontal ligament morphology 0.01092271926507 0.0494282247386805 1.94477201257862 0.833333333333333 23.1 23 1 abnormal metopic suture morphology 0.01092271926507 0.0494282247386805 1.94477201257862 0.833333333333333 23.1 23 1 abnormal heart left atrium morphology 0.01092271926507 0.0494282247386805 1.94477201257862 0.833333333333333 23.1 23 1 abnormal right lung morphology 0.01092271926507 0.0494282247386805 1.94477201257862 0.833333333333333 23.1 23 1 delayed chorioallantoic fusion 0.01092271926507 0.0494282247386805 1.94477201257862 0.833333333333333 23.1 23 1 abnormal oval cell physiology 0.01092271926507 0.0494282247386805 1.94477201257862 0.833333333333333 23.1 23 1 enlarged lymphatic vessel 0.01092271926507 0.0494282247386805 1.94477201257862 0.833333333333333 23.1 23 1 abnormal pharyngeal arch development 0.01092271926507 0.0494282247386805 1.94477201257862 0.833333333333333 23.1 23 1 cerebral arteriovenous malformation 0.01092271926507 0.0494282247386805 1.94477201257862 0.833333333333333 23.1 23 1 thick pulmonary valve cusps 0.01092271926507 0.0494282247386805 1.94477201257862 0.833333333333333 23.1 23 1 thick myocardium 0.01092271926507 0.0494282247386805 1.94477201257862 0.833333333333333 23.1 23 1 abnormal intestinal enteroendocrine cell morphology 0.01092271926507 0.0494282247386805 1.94477201257862 0.833333333333333 23.1 23 1 ectopic ureteric bud 0.01092271926507 0.0494282247386805 1.94477201257862 0.833333333333333 23.1 23 1 delayed limb development 0.01092271926507 0.0494282247386805 1.94477201257862 0.833333333333333 23.1 23 1 abnormal vertebral artery origin 0.01092271926507 0.0494282247386805 1.94477201257862 0.833333333333333 23.1 23 1 ectopic bone 0.01092271926507 0.0494282247386805 1.94477201257862 0.833333333333333 23.1 23 1 atrial septal defect 2.12861949614112e-13 1.60452757474274e-11 1.92786095159967 0.826086956521739 23.1 23 1 increased trabecular bone mass 1.20834076832602e-05 0.000156549357354739 1.9218923418424 0.823529411764706 23.1 23 1 abnormal bronchiole morphology 0.000575962241594782 0.00462163250311942 1.90941252144082 0.818181818181818 23.1 23 1 patent ductus arteriosus 0.000575962241594782 0.00462163250311942 1.90941252144082 0.818181818181818 23.1 23 1 loss of cortex neurons 0.000575962241594782 0.00462163250311942 1.90941252144082 0.818181818181818 23.1 23 1 abnormal radial glial cell morphology 0.000575962241594782 0.00462163250311942 1.90941252144082 0.818181818181818 23.1 23 1 abnormal ureter development 0.000575962241594782 0.00462163250311942 1.90941252144082 0.818181818181818 23.1 23 1 abnormal coronal suture morphology 0.000575962241594782 0.00462163250311942 1.90941252144082 0.818181818181818 23.1 23 1 abnormal dorsal-ventral polarity of the somites 0.000575962241594782 0.00462163250311942 1.90941252144082 0.818181818181818 23.1 23 1 abnormal aorta smooth muscle morphology 0.000575962241594782 0.00462163250311942 1.90941252144082 0.818181818181818 23.1 23 1 aberrant origin of the right subclavian artery 0.000575962241594782 0.00462163250311942 1.90941252144082 0.818181818181818 23.1 23 1 abnormal epicardium morphology 3.34079582950102e-05 0.000389237921587063 1.89615271226415 0.8125 23.1 23 1 bowed radius 3.34079582950102e-05 0.000389237921587063 1.89615271226415 0.8125 23.1 23 1 loose skin 3.34079582950102e-05 0.000389237921587063 1.89615271226415 0.8125 23.1 23 1 heart right ventricle hypertrophy 5.09956670366611e-10 1.95156495005684e-08 1.879946278826 0.805555555555556 23.1 23 1 increased mammary adenocarcinoma incidence 5.50435357231449e-06 7.77705729477278e-05 1.86698113207547 0.8 23.1 23 1 kidney atrophy 5.50435357231449e-06 7.77705729477278e-05 1.86698113207547 0.8 23.1 23 1 decreased muscle cell glucose uptake 5.50435357231449e-06 7.77705729477278e-05 1.86698113207547 0.8 23.1 23 1 fused cornea and lens 0.00158657982854322 0.0104963226688864 1.86698113207547 0.8 23.1 23 1 abnormal immune cell physiology 0.00158657982854322 0.0104963226688864 1.86698113207547 0.8 23.1 23 1 abnormal respiratory mechanics 0.00158657982854322 0.0104963226688864 1.86698113207547 0.8 23.1 23 1 abnormal airway responsiveness 0.00158657982854322 0.0104963226688864 1.86698113207547 0.8 23.1 23 1 aneurysm 0.00158657982854322 0.0104963226688864 1.86698113207547 0.8 23.1 23 1 peritoneal inflammation 0.00158657982854322 0.0104963226688864 1.86698113207547 0.8 23.1 23 1 increased left ventricle diastolic pressure 0.00158657982854322 0.0104963226688864 1.86698113207547 0.8 23.1 23 1 abnormal hindlimb zeugopod morphology 0.00158657982854322 0.0104963226688864 1.86698113207547 0.8 23.1 23 1 osteosclerosis 0.00158657982854322 0.0104963226688864 1.86698113207547 0.8 23.1 23 1 abnormal developmental vascular remodeling 0.00158657982854322 0.0104963226688864 1.86698113207547 0.8 23.1 23 1 increased circulating fructosamine level 0.00158657982854322 0.0104963226688864 1.86698113207547 0.8 23.1 23 1 abnormal left subclavian artery morphology 0.00158657982854322 0.0104963226688864 1.86698113207547 0.8 23.1 23 1 abnormal inferior vena cava valve morphology 0.00158657982854322 0.0104963226688864 1.86698113207547 0.8 23.1 23 1 thin ventricle myocardium compact layer 0.00158657982854322 0.0104963226688864 1.86698113207547 0.8 23.1 23 1 thick aortic valve cusps 0.00158657982854322 0.0104963226688864 1.86698113207547 0.8 23.1 23 1 decreased macrophage cytokine production 0.00158657982854322 0.0104963226688864 1.86698113207547 0.8 23.1 23 1 abnormal artery morphology 1.37690138776032e-09 4.75700305840806e-08 1.86698113207547 0.8 23.1 23 1 delayed intramembranous bone ossification 9.12096801064393e-05 0.000951295929831311 1.86698113207547 0.8 23.1 23 1 liver vascular congestion 9.12096801064393e-05 0.000951295929831311 1.86698113207547 0.8 23.1 23 1 ostium primum atrial septal defect 9.12096801064393e-05 0.000951295929831311 1.86698113207547 0.8 23.1 23 1 heterochrony 9.12096801064393e-05 0.000951295929831311 1.86698113207547 0.8 23.1 23 1 ocular hypertelorism 9.16525756903756e-07 1.63430668121727e-05 1.84753341194969 0.791666666666667 23.1 23 1 abnormal frontal bone morphology 6.3399920649568e-10 2.33640448319704e-08 1.84241559086395 0.789473684210526 23.1 23 1 embryonic lethality between implantation and somite formation, incomplete penetrance 1.47897608202424e-05 0.000187078087470995 1.84241559086395 0.789473684210526 23.1 23 1 subcutaneous edema 1.53843817483626e-07 3.21585290748335e-06 1.83364218328841 0.785714285714286 23.1 23 1 amyloid beta deposits 0.000245464364604522 0.00219637628400629 1.83364218328841 0.785714285714286 23.1 23 1 perimembraneous ventricular septal defect 1.62972939102848e-16 1.93216214211865e-14 1.826394585726 0.782608695652174 23.1 23 1 abnormal pulmonary artery morphology 2.43595039531613e-06 3.84458722013062e-05 1.826394585726 0.782608695652174 23.1 23 1 abnormal hematopoietic stem cell physiology 2.43595039531613e-06 3.84458722013062e-05 1.826394585726 0.782608695652174 23.1 23 1 abnormal thyroid cartilage morphology 3.92478865057945e-05 0.000451151166330642 1.81512054507338 0.777777777777778 23.1 23 1 small geniculate ganglion 0.00428293816023911 0.0232878385731342 1.81512054507338 0.777777777777778 23.1 23 1 dilated uterus 0.00428293816023911 0.0232878385731342 1.81512054507338 0.777777777777778 23.1 23 1 abnormal laryngeal cartilage morphology 0.00428293816023911 0.0232878385731342 1.81512054507338 0.777777777777778 23.1 23 1 premature neuronal precursor differentiation 0.00428293816023911 0.0232878385731342 1.81512054507338 0.777777777777778 23.1 23 1 decreased cellular sensitivity to ionizing radiation 0.00428293816023911 0.0232878385731342 1.81512054507338 0.777777777777778 23.1 23 1 short frontal bone 0.00428293816023911 0.0232878385731342 1.81512054507338 0.777777777777778 23.1 23 1 increased neuronal precursor cell number 0.00428293816023911 0.0232878385731342 1.81512054507338 0.777777777777778 23.1 23 1 abnormal intervertebral disk development 0.00428293816023911 0.0232878385731342 1.81512054507338 0.777777777777778 23.1 23 1 positive geotaxis 0.00428293816023911 0.0232878385731342 1.81512054507338 0.777777777777778 23.1 23 1 iris coloboma 0.00428293816023911 0.0232878385731342 1.81512054507338 0.777777777777778 23.1 23 1 decreased effector memory CD4-positive, alpha-beta T cell number 0.00428293816023911 0.0232878385731342 1.81512054507338 0.777777777777778 23.1 23 1 decreased bone trabecular spacing 0.00428293816023911 0.0232878385731342 1.81512054507338 0.777777777777778 23.1 23 1 abnormal ductus venosus valve topology 0.00428293816023911 0.0232878385731342 1.81512054507338 0.777777777777778 23.1 23 1 symmetric azygos veins 0.00428293816023911 0.0232878385731342 1.81512054507338 0.777777777777778 23.1 23 1 abnormal capillary morphology 6.81146078329514e-08 1.56884339800432e-06 1.80675593426659 0.774193548387097 23.1 23 1 cleft upper lip 6.40407574145478e-06 8.89951866305518e-05 1.80333404802744 0.772727272727273 23.1 23 1 abnormal ureter morphology 1.0594036610901e-06 1.83004625483447e-05 1.79517416545718 0.769230769230769 23.1 23 1 abnormal aorta tunica media morphology 0.000649742911192796 0.00510658923093864 1.79517416545718 0.769230769230769 23.1 23 1 abnormal bone marrow cavity morphology 0.000102712747783198 0.00104284881677839 1.78461431742508 0.764705882352941 23.1 23 1 abnormal interatrial septum morphology 0.000102712747783198 0.00104284881677839 1.78461431742508 0.764705882352941 23.1 23 1 hyperlipidemia 0.000102712747783198 0.00104284881677839 1.78461431742508 0.764705882352941 23.1 23 1 decreased neuron apoptosis 5.04290524995272e-09 1.52782263723301e-07 1.78100173783515 0.763157894736842 23.1 23 1 abnormal scapula morphology 1.6635668230903e-05 0.000205069648049876 1.77807726864331 0.761904761904762 23.1 23 1 complete atrioventricular septal defect 1.6635668230903e-05 0.000205069648049876 1.77807726864331 0.761904761904762 23.1 23 1 increased muscle cell glucose uptake 1.6635668230903e-05 0.000205069648049876 1.77807726864331 0.761904761904762 23.1 23 1 diaphragmatic hernia 2.7376839252805e-06 4.26958543205971e-05 1.7736320754717 0.76 23.1 23 1 abnormal apoptosis 4.3003991856173e-12 2.47421608477005e-10 1.77190338923829 0.759259259259259 23.1 23 1 increased mortality induced by gamma-irradiation 4.55628076426013e-07 8.78585147371866e-06 1.77041314248536 0.758620689655172 23.1 23 1 abnormal aorta morphology 7.6462778886745e-08 1.72910147709798e-06 1.76797455688965 0.757575757575758 23.1 23 1 malocclusion 1.29138562187804e-08 3.54952677836644e-07 1.76606323304437 0.756756756756757 23.1 23 1 increased T cell derived lymphoma incidence 6.38713722042455e-11 3.02628644491544e-09 1.76220157874471 0.755102040816326 23.1 23 1 abnormal pharyngeal arch morphology 3.2801960314933e-08 8.03890406732964e-07 1.75029481132075 0.75 23.1 23 1 abnormal pericardium morphology 4.26459825640266e-05 0.00048000851415392 1.75029481132075 0.75 23.1 23 1 spleen atrophy 4.26459825640266e-05 0.00048000851415392 1.75029481132075 0.75 23.1 23 1 abnormal induced retinal neovascularization 4.26459825640266e-05 0.00048000851415392 1.75029481132075 0.75 23.1 23 1 increased skin tumor incidence 4.26459825640266e-05 0.00048000851415392 1.75029481132075 0.75 23.1 23 1 overriding aortic valve 1.61783172437474e-10 7.0602744111968e-09 1.75029481132075 0.75 23.1 23 1 decreased body height 6.99422431055324e-06 9.61222816160286e-05 1.75029481132075 0.75 23.1 23 1 abnormal truncus arteriosus septation 6.99422431055324e-06 9.61222816160286e-05 1.75029481132075 0.75 23.1 23 1 abnormal tympanic ring morphology 0.000264614845540727 0.00233259877555975 1.75029481132075 0.75 23.1 23 1 disorganized yolk sac vascular plexus 0.000264614845540727 0.00233259877555975 1.75029481132075 0.75 23.1 23 1 intraventricular hemorrhage 0.000264614845540727 0.00233259877555975 1.75029481132075 0.75 23.1 23 1 abnormal pulmonary alveolus wall morphology 0.000264614845540727 0.00233259877555975 1.75029481132075 0.75 23.1 23 1 decreased fibroblast apoptosis 0.000264614845540727 0.00233259877555975 1.75029481132075 0.75 23.1 23 1 impaired embryo implantation 0.00168699690740641 0.0106507736222676 1.75029481132075 0.75 23.1 23 1 abnormal thymus involution 0.00168699690740641 0.0106507736222676 1.75029481132075 0.75 23.1 23 1 interstitial pneumonia 0.00168699690740641 0.0106507736222676 1.75029481132075 0.75 23.1 23 1 abnormal tracheal ciliated epithelium morphology 0.00168699690740641 0.0106507736222676 1.75029481132075 0.75 23.1 23 1 abnormal gastrocnemius morphology 0.00168699690740641 0.0106507736222676 1.75029481132075 0.75 23.1 23 1 abnormal vascular endothelial cell development 0.00168699690740641 0.0106507736222676 1.75029481132075 0.75 23.1 23 1 increased osteosarcoma incidence 0.00168699690740641 0.0106507736222676 1.75029481132075 0.75 23.1 23 1 bowed ulna 0.00168699690740641 0.0106507736222676 1.75029481132075 0.75 23.1 23 1 abnormal palatine bone morphology 0.00168699690740641 0.0106507736222676 1.75029481132075 0.75 23.1 23 1 decreased prostaglandin level 0.00168699690740641 0.0106507736222676 1.75029481132075 0.75 23.1 23 1 decreased mammary gland epithelial cell proliferation 0.00168699690740641 0.0106507736222676 1.75029481132075 0.75 23.1 23 1 increased skeletal muscle glycogen level 0.00168699690740641 0.0106507736222676 1.75029481132075 0.75 23.1 23 1 persistent right dorsal aorta 0.00168699690740641 0.0106507736222676 1.75029481132075 0.75 23.1 23 1 increased type II pneumocyte number 0.00168699690740641 0.0106507736222676 1.75029481132075 0.75 23.1 23 1 abnormal vitelline vein connection 0.00168699690740641 0.0106507736222676 1.75029481132075 0.75 23.1 23 1 abnormal bone marrow development 0.011276589965508 0.0494282247386805 1.75029481132075 0.75 23.1 23 1 abnormal pulmonary circulation 0.011276589965508 0.0494282247386805 1.75029481132075 0.75 23.1 23 1 decreased aerobic running capacity 0.011276589965508 0.0494282247386805 1.75029481132075 0.75 23.1 23 1 hypospadia 0.011276589965508 0.0494282247386805 1.75029481132075 0.75 23.1 23 1 abnormal neuron apoptosis 0.011276589965508 0.0494282247386805 1.75029481132075 0.75 23.1 23 1 abnormal umbilical artery morphology 0.011276589965508 0.0494282247386805 1.75029481132075 0.75 23.1 23 1 colon polyps 0.011276589965508 0.0494282247386805 1.75029481132075 0.75 23.1 23 1 binucleate 0.011276589965508 0.0494282247386805 1.75029481132075 0.75 23.1 23 1 increased left ventricle systolic pressure 0.011276589965508 0.0494282247386805 1.75029481132075 0.75 23.1 23 1 abnormal forelimb zeugopod morphology 0.011276589965508 0.0494282247386805 1.75029481132075 0.75 23.1 23 1 tau protein deposits 0.011276589965508 0.0494282247386805 1.75029481132075 0.75 23.1 23 1 bowed fibula 0.011276589965508 0.0494282247386805 1.75029481132075 0.75 23.1 23 1 accumulation of giant lysosomes in kidney/renal tubule cells 0.011276589965508 0.0494282247386805 1.75029481132075 0.75 23.1 23 1 abnormal somite size 0.011276589965508 0.0494282247386805 1.75029481132075 0.75 23.1 23 1 abnormal ilium morphology 0.011276589965508 0.0494282247386805 1.75029481132075 0.75 23.1 23 1 abnormal epidermal lamellar body morphology 0.011276589965508 0.0494282247386805 1.75029481132075 0.75 23.1 23 1 abnormal meiotic spindle morphology 0.011276589965508 0.0494282247386805 1.75029481132075 0.75 23.1 23 1 decreased hippocampus pyramidal cell number 0.011276589965508 0.0494282247386805 1.75029481132075 0.75 23.1 23 1 abnormal brain ependyma morphology 0.011276589965508 0.0494282247386805 1.75029481132075 0.75 23.1 23 1 decreased quadriceps weight 0.011276589965508 0.0494282247386805 1.75029481132075 0.75 23.1 23 1 ostium secundum atrial septal defect 0.011276589965508 0.0494282247386805 1.75029481132075 0.75 23.1 23 1 anomalous pulmonary venous connection 0.011276589965508 0.0494282247386805 1.75029481132075 0.75 23.1 23 1 pulmonary artery hypoplasia 0.011276589965508 0.0494282247386805 1.75029481132075 0.75 23.1 23 1 abnormal stomach position or orientation 0.011276589965508 0.0494282247386805 1.75029481132075 0.75 23.1 23 1 decreased alveolar lamellar body number 0.011276589965508 0.0494282247386805 1.75029481132075 0.75 23.1 23 1 abnormal bronchiole epithelium morphology 0.011276589965508 0.0494282247386805 1.75029481132075 0.75 23.1 23 1 abnormal kidney mesenchyme morphology 0.011276589965508 0.0494282247386805 1.75029481132075 0.75 23.1 23 1 abnormal heart echocardiography feature 0.011276589965508 0.0494282247386805 1.75029481132075 0.75 23.1 23 1 increased cardiac stroke volume 0.011276589965508 0.0494282247386805 1.75029481132075 0.75 23.1 23 1 prolonged PQ interval 0.011276589965508 0.0494282247386805 1.75029481132075 0.75 23.1 23 1 absent hypoglossal canal 0.011276589965508 0.0494282247386805 1.75029481132075 0.75 23.1 23 1 small lung 6.97405082719215e-11 3.27319838351707e-09 1.73885497595265 0.745098039215686 23.1 23 1 kidney failure 2.38312771788255e-09 8.01085161923357e-08 1.73672663448881 0.744186046511628 23.1 23 1 ventricular septal defect 1.97968572853956e-26 6.15558531217768e-24 1.73313505826859 0.742647058823529 23.1 23 1 abnormal postnatal growth/weight/body size 4.90019663544005e-07 9.34041312694033e-06 1.73147443700548 0.741935483870968 23.1 23 1 pale kidney 4.90019663544005e-07 9.34041312694033e-06 1.73147443700548 0.741935483870968 23.1 23 1 abnormal atrioventricular cushion morphology 2.92720710810311e-06 4.429194530137e-05 1.72868623340321 0.740740740740741 23.1 23 1 increased B cell derived lymphoma incidence 1.74341896334548e-10 7.41325584841345e-09 1.72695754716981 0.74 23.1 23 1 abnormal palatal shelf fusion at midline 1.76470975555143e-05 0.000214835003617233 1.72492821985234 0.739130434782609 23.1 23 1 incomplete embryo turning 1.28219922444852e-11 6.71467488592778e-10 1.71958788480636 0.736842105263158 23.1 23 1 short maxilla 2.06109045101937e-07 4.2024282761563e-06 1.71597530521643 0.735294117647059 23.1 23 1 trabecula carnea hypoplasia 2.52364031275423e-09 8.37007370396821e-08 1.71139937106918 0.733333333333333 23.1 23 1 abnormal lactation 1.22187362390716e-06 2.08894202025365e-05 1.71139937106918 0.733333333333333 23.1 23 1 decreased chondrocyte number 0.000669664746974246 0.00521374353082453 1.71139937106918 0.733333333333333 23.1 23 1 dilated ureter 0.000669664746974246 0.00521374353082453 1.71139937106918 0.733333333333333 23.1 23 1 abnormal pericyte morphology 0.000669664746974246 0.00521374353082453 1.71139937106918 0.733333333333333 23.1 23 1 abnormal secondary palate development 0.000669664746974246 0.00521374353082453 1.71139937106918 0.733333333333333 23.1 23 1 thick ventricular wall 1.47507479629454e-08 3.96675519544073e-07 1.70760469397147 0.731707317073171 23.1 23 1 abnormal Mullerian duct morphology 7.29301607094012e-06 9.94048080902112e-05 1.70541545718433 0.730769230769231 23.1 23 1 pulmonary edema 7.29301607094012e-06 9.94048080902112e-05 1.70541545718433 0.730769230769231 23.1 23 1 kidney cysts 2.99565212734447e-14 2.5259948022947e-12 1.70298954614992 0.72972972972973 23.1 23 1 decreased width of hypertrophic chondrocyte zone 8.64998413745459e-08 1.91260760372607e-06 1.70298954614992 0.72972972972973 23.1 23 1 abnormal basisphenoid bone morphology 4.39199148694317e-05 0.000489913848599603 1.69725557461407 0.727272727272727 23.1 23 1 increased skin papilloma incidence 4.39199148694317e-05 0.000489913848599603 1.69725557461407 0.727272727272727 23.1 23 1 abnormal tracheal cartilage morphology 4.39199148694317e-05 0.000489913848599603 1.69725557461407 0.727272727272727 23.1 23 1 increased adenoma incidence 4.39199148694317e-05 0.000489913848599603 1.69725557461407 0.727272727272727 23.1 23 1 premature suture closure 0.00428156006040572 0.0232878385731342 1.69725557461407 0.727272727272727 23.1 23 1 abnormal eye distance/ position 0.00428156006040572 0.0232878385731342 1.69725557461407 0.727272727272727 23.1 23 1 impaired myelopoiesis 0.00428156006040572 0.0232878385731342 1.69725557461407 0.727272727272727 23.1 23 1 abnormal proximal-distal axis patterning 0.00428156006040572 0.0232878385731342 1.69725557461407 0.727272727272727 23.1 23 1 abnormal larynx morphology 0.00428156006040572 0.0232878385731342 1.69725557461407 0.727272727272727 23.1 23 1 abnormal Bruch membrane morphology 0.00428156006040572 0.0232878385731342 1.69725557461407 0.727272727272727 23.1 23 1 blood in lymph vessels 3.01317537646278e-06 4.51522514997058e-05 1.68993981782694 0.724137931034483 23.1 23 1 pulmonary hypoplasia 2.61313033435863e-09 8.55284435094353e-08 1.68822761942995 0.723404255319149 23.1 23 1 abnormal maxilla morphology 1.90093242971778e-10 7.88094903153831e-09 1.68546907756813 0.722222222222222 23.1 23 1 lowered ear position 0.000267721387104446 0.00233259877555975 1.68546907756813 0.722222222222222 23.1 23 1 delayed kidney development 0.000267721387104446 0.00233259877555975 1.68546907756813 0.722222222222222 23.1 23 1 blepharoptosis 0.000267721387104446 0.00233259877555975 1.68546907756813 0.722222222222222 23.1 23 1 abnormal redox activity 0.000267721387104446 0.00233259877555975 1.68546907756813 0.722222222222222 23.1 23 1 long tibia 0.000267721387104446 0.00233259877555975 1.68546907756813 0.722222222222222 23.1 23 1 atrioventricular block 0.000267721387104446 0.00233259877555975 1.68546907756813 0.722222222222222 23.1 23 1 abnormal aerobic respiration 0.000267721387104446 0.00233259877555975 1.68546907756813 0.722222222222222 23.1 23 1 increased adipocyte glucose uptake 0.000267721387104446 0.00233259877555975 1.68546907756813 0.722222222222222 23.1 23 1 abnormal left-right axis patterning 1.51737506401043e-08 4.03686681468014e-07 1.68245392716104 0.720930232558139 23.1 23 1 mandible hypoplasia 1.79396138726832e-05 0.000217681900040485 1.68028301886792 0.72 23.1 23 1 double outlet right ventricle 4.05084915098502e-19 7.28947331382015e-17 1.67941059777817 0.719626168224299 23.1 23 1 absent vitelline blood vessels 8.00719834740408e-11 3.6885010905866e-09 1.67864531612049 0.719298245614035 23.1 23 1 abnormal embryonic hematopoiesis 1.24523492765738e-06 2.09292019091063e-05 1.67736586084906 0.71875 23.1 23 1 increased fibroblast apoptosis 1.24523492765738e-06 2.09292019091063e-05 1.67736586084906 0.71875 23.1 23 1 failure of heart looping 8.82860046510777e-08 1.93430853743535e-06 1.67549588776004 0.717948717948718 23.1 23 1 delayed wound healing 6.34750200871692e-09 1.86856937830572e-07 1.6741950369155 0.717391304347826 23.1 23 1 rib bifurcation 7.34232896313256e-06 9.98035152775532e-05 1.6669474393531 0.714285714285714 23.1 23 1 midline facial cleft 0.00166043927766348 0.0106507736222676 1.6669474393531 0.714285714285714 23.1 23 1 abnormal blood flow velocity 0.00166043927766348 0.0106507736222676 1.6669474393531 0.714285714285714 23.1 23 1 abnormal kidney blood vessel morphology 0.00166043927766348 0.0106507736222676 1.6669474393531 0.714285714285714 23.1 23 1 increased lactate dehydrogenase level 0.00166043927766348 0.0106507736222676 1.6669474393531 0.714285714285714 23.1 23 1 abnormal vascular endothelial cell migration 0.00166043927766348 0.0106507736222676 1.6669474393531 0.714285714285714 23.1 23 1 vascular smooth muscle hypoplasia 0.00166043927766348 0.0106507736222676 1.6669474393531 0.714285714285714 23.1 23 1 abnormal decidualization 0.00166043927766348 0.0106507736222676 1.6669474393531 0.714285714285714 23.1 23 1 lysosomal protein accumulation 0.00166043927766348 0.0106507736222676 1.6669474393531 0.714285714285714 23.1 23 1 abnormal viscerocranium morphology 0.00166043927766348 0.0106507736222676 1.6669474393531 0.714285714285714 23.1 23 1 spina bifida occulta 0.00166043927766348 0.0106507736222676 1.6669474393531 0.714285714285714 23.1 23 1 sternebra fusion 0.00166043927766348 0.0106507736222676 1.6669474393531 0.714285714285714 23.1 23 1 pulmonary alveolar hemorrhage 0.00166043927766348 0.0106507736222676 1.6669474393531 0.714285714285714 23.1 23 1 decreased compact bone area 0.00166043927766348 0.0106507736222676 1.6669474393531 0.714285714285714 23.1 23 1 abnormal renal tubule epithelial cell primary cilium morphology 0.00166043927766348 0.0106507736222676 1.6669474393531 0.714285714285714 23.1 23 1 abnormal vitelline vein topology 0.00166043927766348 0.0106507736222676 1.6669474393531 0.714285714285714 23.1 23 1 failure of atrioventricular cushion closure 0.028767251746122 0.1023727306416 1.6669474393531 0.714285714285714 23.1 23 1 cellular necrosis 0.028767251746122 0.1023727306416 1.6669474393531 0.714285714285714 23.1 23 1 polyphalangy 0.028767251746122 0.1023727306416 1.6669474393531 0.714285714285714 23.1 23 1 maxilla hypoplasia 0.028767251746122 0.1023727306416 1.6669474393531 0.714285714285714 23.1 23 1 mammary gland hyperplasia 0.028767251746122 0.1023727306416 1.6669474393531 0.714285714285714 23.1 23 1 small L4 dorsal root ganglion 0.028767251746122 0.1023727306416 1.6669474393531 0.714285714285714 23.1 23 1 decreased Schwann cell number 0.028767251746122 0.1023727306416 1.6669474393531 0.714285714285714 23.1 23 1 abnormal circulating alanine transaminase level 0.028767251746122 0.1023727306416 1.6669474393531 0.714285714285714 23.1 23 1 abnormal tumor incidence 0.028767251746122 0.1023727306416 1.6669474393531 0.714285714285714 23.1 23 1 abnormal brain ventricular system morphology 0.028767251746122 0.1023727306416 1.6669474393531 0.714285714285714 23.1 23 1 decreased mortality induced by ionizing radiation 0.028767251746122 0.1023727306416 1.6669474393531 0.714285714285714 23.1 23 1 decreased cardiomyocyte apoptosis 0.028767251746122 0.1023727306416 1.6669474393531 0.714285714285714 23.1 23 1 abnormal sinus venosus morphology 0.028767251746122 0.1023727306416 1.6669474393531 0.714285714285714 23.1 23 1 anuria 0.028767251746122 0.1023727306416 1.6669474393531 0.714285714285714 23.1 23 1 skeletal muscle interstitial fibrosis 0.028767251746122 0.1023727306416 1.6669474393531 0.714285714285714 23.1 23 1 absent deltoid tuberosity 0.028767251746122 0.1023727306416 1.6669474393531 0.714285714285714 23.1 23 1 increased prostate gland weight 0.028767251746122 0.1023727306416 1.6669474393531 0.714285714285714 23.1 23 1 atherosclerotic lesions 0.028767251746122 0.1023727306416 1.6669474393531 0.714285714285714 23.1 23 1 absent fibula 0.028767251746122 0.1023727306416 1.6669474393531 0.714285714285714 23.1 23 1 retinal pigment epithelium atrophy 0.028767251746122 0.1023727306416 1.6669474393531 0.714285714285714 23.1 23 1 uremia 0.028767251746122 0.1023727306416 1.6669474393531 0.714285714285714 23.1 23 1 abnormal uterus physiology 0.028767251746122 0.1023727306416 1.6669474393531 0.714285714285714 23.1 23 1 abnormal sperm annulus morphology 0.028767251746122 0.1023727306416 1.6669474393531 0.714285714285714 23.1 23 1 abnormal cerebellum white matter morphology 0.028767251746122 0.1023727306416 1.6669474393531 0.714285714285714 23.1 23 1 focal dorsal hair loss 0.028767251746122 0.1023727306416 1.6669474393531 0.714285714285714 23.1 23 1 heart right ventricle outflow tract stenosis 0.028767251746122 0.1023727306416 1.6669474393531 0.714285714285714 23.1 23 1 increased right ventricle systolic pressure 0.028767251746122 0.1023727306416 1.6669474393531 0.714285714285714 23.1 23 1 small lung saccule 0.028767251746122 0.1023727306416 1.6669474393531 0.714285714285714 23.1 23 1 embryonic lethality at implantation, incomplete penetrance 0.028767251746122 0.1023727306416 1.6669474393531 0.714285714285714 23.1 23 1 small tail bud 0.028767251746122 0.1023727306416 1.6669474393531 0.714285714285714 23.1 23 1 absent connection between subcutaneous lymph vessels and lymph sac 0.028767251746122 0.1023727306416 1.6669474393531 0.714285714285714 23.1 23 1 abnormal embryonic epiblast morphology 5.14875266008407e-07 9.77673453584666e-06 1.6669474393531 0.714285714285714 23.1 23 1 abnormal tumor vascularization 0.000107671768396835 0.00107563664211698 1.6669474393531 0.714285714285714 23.1 23 1 absent segment of posterior cerebral artery 0.000107671768396835 0.00107563664211698 1.6669474393531 0.714285714285714 23.1 23 1 abnormal placenta vasculature 1.10936658892683e-09 3.88668928162746e-08 1.6605361030479 0.711538461538462 23.1 23 1 abnormal cell migration 1.52945995396392e-08 4.04737408030345e-07 1.65953878406709 0.711111111111111 23.1 23 1 lethality throughout fetal growth and development, incomplete penetrance 1.30315931620496e-29 5.40268133176641e-27 1.65577237272057 0.709497206703911 23.1 23 1 abnormal cell differentiation 8.81979530203766e-08 1.93430853743535e-06 1.65068453750575 0.707317073170732 23.1 23 1 delayed bone ossification 4.41008433414774e-13 3.00550267977876e-11 1.64916666666667 0.706666666666667 23.1 23 1 enlarged liver sinusoidal spaces 1.23685049767486e-06 2.09292019091063e-05 1.64733629300777 0.705882352941177 23.1 23 1 lung hemorrhage 1.23685049767486e-06 2.09292019091063e-05 1.64733629300777 0.705882352941177 23.1 23 1 abnormal direction of heart looping 1.23685049767486e-06 2.09292019091063e-05 1.64733629300777 0.705882352941177 23.1 23 1 abnormal cranial suture morphology 0.000653179880158797 0.00512550458011043 1.64733629300777 0.705882352941177 23.1 23 1 failure of chorioallantoic fusion 2.65079022180341e-09 8.61939957743267e-08 1.64733629300777 0.705882352941177 23.1 23 1 abnormal cell adhesion 1.10389902456991e-09 3.88668928162746e-08 1.64225192173305 0.703703703703704 23.1 23 1 increased brain weight 1.76618123576781e-05 0.000214835003617233 1.64225192173305 0.703703703703704 23.1 23 1 abnormal fetal cardiomyocyte proliferation 1.76618123576781e-05 0.000214835003617233 1.64225192173305 0.703703703703704 23.1 23 1 abnormal primordial germ cell migration 0.0105744409341962 0.0488920479996524 1.63360849056604 0.7 23.1 23 1 abnormal bone healing 0.0105744409341962 0.0488920479996524 1.63360849056604 0.7 23.1 23 1 impaired basement membrane formation 0.0105744409341962 0.0488920479996524 1.63360849056604 0.7 23.1 23 1 abnormal tibialis anterior morphology 0.0105744409341962 0.0488920479996524 1.63360849056604 0.7 23.1 23 1 abnormal gas homeostasis 0.0105744409341962 0.0488920479996524 1.63360849056604 0.7 23.1 23 1 abnormal respiratory conducting tube morphology 0.0105744409341962 0.0488920479996524 1.63360849056604 0.7 23.1 23 1 abnormal gonadal fat pad morphology 0.0105744409341962 0.0488920479996524 1.63360849056604 0.7 23.1 23 1 increased platelet aggregation 0.0105744409341962 0.0488920479996524 1.63360849056604 0.7 23.1 23 1 decreased transitional stage T2 B cell number 0.0105744409341962 0.0488920479996524 1.63360849056604 0.7 23.1 23 1 abnormal hippocampus neuron morphology 0.0105744409341962 0.0488920479996524 1.63360849056604 0.7 23.1 23 1 aorta stenosis 0.0105744409341962 0.0488920479996524 1.63360849056604 0.7 23.1 23 1 sinus bradycardia 0.0105744409341962 0.0488920479996524 1.63360849056604 0.7 23.1 23 1 decreased macrophage apoptosis 0.0105744409341962 0.0488920479996524 1.63360849056604 0.7 23.1 23 1 abnormal interventricular septum morphology 6.28514414093844e-09 1.86122572030766e-07 1.63360849056604 0.7 23.1 23 1 atrioventricular septal defect 2.60906001776029e-09 8.55284435094353e-08 1.62920523317907 0.69811320754717 23.1 23 1 dextrocardia 2.93795818079439e-06 4.429194530137e-05 1.62653659233848 0.696969696969697 23.1 23 1 decreased brown adipose tissue amount 2.93795818079439e-06 4.429194530137e-05 1.62653659233848 0.696969696969697 23.1 23 1 dilated heart atrium 2.93795818079439e-06 4.429194530137e-05 1.62653659233848 0.696969696969697 23.1 23 1 short mandible 1.08367873886114e-09 3.85092980416727e-08 1.62527375336927 0.696428571428571 23.1 23 1 microcephaly 1.38765505310046e-11 7.1912332178904e-10 1.62346185397867 0.695652173913043 23.1 23 1 abnormal vitelline vasculature morphology 2.32975595102328e-18 3.62204245510651e-16 1.62346185397867 0.695652173913043 23.1 23 1 fragile skeleton 0.000103972068729814 0.00104921103839924 1.62346185397867 0.695652173913043 23.1 23 1 abnormal cardiovascular development 0.000103972068729814 0.00104921103839924 1.62346185397867 0.695652173913043 23.1 23 1 abnormal Wolffian duct morphology 0.000103972068729814 0.00104921103839924 1.62346185397867 0.695652173913043 23.1 23 1 pericardial effusion 1.87243890274919e-10 7.82805339594725e-09 1.61855219111382 0.693548387096774 23.1 23 1 absent common myeloid progenitor cells 0.00402081839888704 0.0225773945084233 1.61565674891147 0.692307692307692 23.1 23 1 absent myocardial trabeculae 0.00402081839888704 0.0225773945084233 1.61565674891147 0.692307692307692 23.1 23 1 increased foot pad pigmentation 0.00402081839888704 0.0225773945084233 1.61565674891147 0.692307692307692 23.1 23 1 abnormal pulmonary alveolus epithelial cell morphology 0.00402081839888704 0.0225773945084233 1.61565674891147 0.692307692307692 23.1 23 1 abnormal lung interstitium morphology 0.00402081839888704 0.0225773945084233 1.61565674891147 0.692307692307692 23.1 23 1 abnormal soleus morphology 0.00402081839888704 0.0225773945084233 1.61565674891147 0.692307692307692 23.1 23 1 muscle fatigue 0.00402081839888704 0.0225773945084233 1.61565674891147 0.692307692307692 23.1 23 1 small interparietal bone 0.00402081839888704 0.0225773945084233 1.61565674891147 0.692307692307692 23.1 23 1 abnormal exocrine pancreas morphology 0.00402081839888704 0.0225773945084233 1.61565674891147 0.692307692307692 23.1 23 1 abnormal vertebral arch development 0.00402081839888704 0.0225773945084233 1.61565674891147 0.692307692307692 23.1 23 1 small pituitary gland 0.00402081839888704 0.0225773945084233 1.61565674891147 0.692307692307692 23.1 23 1 abnormal outer ear morphology 1.69626702668432e-05 0.000208368603895173 1.60946649316851 0.689655172413793 23.1 23 1 abnormal craniofacial morphology 4.01632340003101e-16 4.25132104577751e-14 1.60868519875435 0.689320388349515 23.1 23 1 abnormal angiogenesis 5.6191551898277e-12 3.10614411882143e-10 1.60837901580826 0.689189189189189 23.1 23 1 abnormal vertebral body morphology 6.89520306783062e-06 9.52878757290482e-05 1.60443691037736 0.6875 23.1 23 1 failure of primitive streak formation 6.89520306783062e-06 9.52878757290482e-05 1.60443691037736 0.6875 23.1 23 1 absent mandible 0.00156077453012799 0.0104963226688864 1.60443691037736 0.6875 23.1 23 1 vasculature congestion 0.00156077453012799 0.0104963226688864 1.60443691037736 0.6875 23.1 23 1 decreased mast cell number 0.00156077453012799 0.0104963226688864 1.60443691037736 0.6875 23.1 23 1 bowed tibia 0.00156077453012799 0.0104963226688864 1.60443691037736 0.6875 23.1 23 1 blepharitis 0.00156077453012799 0.0104963226688864 1.60443691037736 0.6875 23.1 23 1 thick pulmonary interalveolar septum 2.81206918494711e-06 4.30462898311134e-05 1.60026954177898 0.685714285714286 23.1 23 1 ovary cysts 2.81206918494711e-06 4.30462898311134e-05 1.60026954177898 0.685714285714286 23.1 23 1 increased carcinoma incidence 2.81206918494711e-06 4.30462898311134e-05 1.60026954177898 0.685714285714286 23.1 23 1 abnormal midbrain development 2.81206918494711e-06 4.30462898311134e-05 1.60026954177898 0.685714285714286 23.1 23 1 decreased glycogen level 2.81206918494711e-06 4.30462898311134e-05 1.60026954177898 0.685714285714286 23.1 23 1 shiny skin 0.00061436800924251 0.00489036935357038 1.59676017874876 0.684210526315789 23.1 23 1 abnormal nasal septum morphology 0.00061436800924251 0.00489036935357038 1.59676017874876 0.684210526315789 23.1 23 1 hemopericardium 4.71425742642068e-07 9.05537864727525e-06 1.59376438104004 0.682926829268293 23.1 23 1 abnormal lung development 3.90470976535724e-13 2.73604663135947e-11 1.59242508324084 0.682352941176471 23.1 23 1 abnormal vascular development 1.73470284700164e-10 7.41325584841345e-09 1.59117710120069 0.681818181818182 23.1 23 1 increased myocardial infarction size 0.000244282883098414 0.0021897429611074 1.59117710120069 0.681818181818182 23.1 23 1 abnormal vascular branching morphogenesis 0.000244282883098414 0.0021897429611074 1.59117710120069 0.681818181818182 23.1 23 1 abnormal basement membrane morphology 0.000244282883098414 0.0021897429611074 1.59117710120069 0.681818181818182 23.1 23 1 decreased spleen weight 7.20101052826974e-11 3.34813339982635e-09 1.58963973202078 0.681159420289855 23.1 23 1 decreased cell proliferation 1.03532896641754e-26 3.4338410719515e-24 1.58945690973993 0.681081081081081 23.1 23 1 hemorrhage 1.67789119830484e-33 7.58864428324233e-31 1.58892011240466 0.680851063829787 23.1 23 1 increased cellular sensitivity to gamma-irradiation 7.96814466455328e-08 1.77764662359429e-06 1.58892011240466 0.680851063829787 23.1 23 1 hydrops fetalis 2.99102684335175e-11 1.53405758202835e-09 1.5882304769392 0.680555555555556 23.1 23 1 abnormal egg cylinder morphology 9.787319911561e-05 0.000999834015606078 1.58693396226415 0.68 23.1 23 1 abnormal somite shape 3.944738841283e-05 0.000451151166330642 1.58360006738544 0.678571428571429 23.1 23 1 increased bone resorption 3.944738841283e-05 0.000451151166330642 1.58360006738544 0.678571428571429 23.1 23 1 abnormal mitotic spindle morphology 3.944738841283e-05 0.000451151166330642 1.58360006738544 0.678571428571429 23.1 23 1 inner cell mass degeneration 1.59751414037843e-05 0.000199188793192549 1.58091144248326 0.67741935483871 23.1 23 1 abnormal T cell proliferation 1.59751414037843e-05 0.000199188793192549 1.58091144248326 0.67741935483871 23.1 23 1 preaxial polydactyly 1.59751414037843e-05 0.000199188793192549 1.58091144248326 0.67741935483871 23.1 23 1 pericardial edema 1.64755152769451e-10 7.12745117415668e-09 1.57869728079911 0.676470588235294 23.1 23 1 abnormal forelimb morphology 1.82465194379494e-07 3.73565572855137e-06 1.57272867104184 0.673913043478261 23.1 23 1 embryonic lethality between implantation and placentation, complete penetrance 1.82465194379494e-07 3.73565572855137e-06 1.57272867104184 0.673913043478261 23.1 23 1 abnormal definitive hematopoiesis 3.11683560835381e-13 2.24728364515366e-11 1.55581761006289 0.666666666666667 23.1 23 1 hydronephrosis 4.32676983668331e-12 2.47421608477005e-10 1.55581761006289 0.666666666666667 23.1 23 1 abnormal kidney development 4.93041156856496e-09 1.50483420574299e-07 1.55581761006289 0.666666666666667 23.1 23 1 absent mesoderm 4.93041156856496e-09 1.50483420574299e-07 1.55581761006289 0.666666666666667 23.1 23 1 abnormal mandible morphology 2.8885383171193e-08 7.25781723619622e-07 1.55581761006289 0.666666666666667 23.1 23 1 decreased tumor growth/size 2.8885383171193e-08 7.25781723619622e-07 1.55581761006289 0.666666666666667 23.1 23 1 abnormal cartilage morphology 1.00832693714497e-06 1.76634736348458e-05 1.55581761006289 0.666666666666667 23.1 23 1 spina bifida 1.00832693714497e-06 1.76634736348458e-05 1.55581761006289 0.666666666666667 23.1 23 1 abnormal lysosome morphology 6.03013357479917e-06 8.40333740465711e-05 1.55581761006289 0.666666666666667 23.1 23 1 single kidney 1.48096928419031e-05 0.000187078087470995 1.55581761006289 0.666666666666667 23.1 23 1 abnormal heart valve morphology 9.03597520644587e-05 0.000950401197718144 1.55581761006289 0.666666666666667 23.1 23 1 abnormal type II pneumocyte morphology 9.03597520644587e-05 0.000950401197718144 1.55581761006289 0.666666666666667 23.1 23 1 thick interventricular septum 9.03597520644587e-05 0.000950401197718144 1.55581761006289 0.666666666666667 23.1 23 1 abnormal lung saccule morphology 0.000224879483888603 0.00204903925338059 1.55581761006289 0.666666666666667 23.1 23 1 left pulmonary isomerism 0.000563440969511541 0.0045877558483141 1.55581761006289 0.666666666666667 23.1 23 1 vascular ring 0.000563440969511541 0.0045877558483141 1.55581761006289 0.666666666666667 23.1 23 1 abnormal bile duct morphology 0.0014240968662675 0.00975879050920219 1.55581761006289 0.666666666666667 23.1 23 1 small thoracic cage 0.0014240968662675 0.00975879050920219 1.55581761006289 0.666666666666667 23.1 23 1 abnormal hypoglossal nerve topology 0.0014240968662675 0.00975879050920219 1.55581761006289 0.666666666666667 23.1 23 1 abnormal bronchus morphology 0.00364198833904194 0.0210195962723128 1.55581761006289 0.666666666666667 23.1 23 1 abnormal lymph node B cell domain morphology 0.00364198833904194 0.0210195962723128 1.55581761006289 0.666666666666667 23.1 23 1 abnormal ear development 0.00364198833904194 0.0210195962723128 1.55581761006289 0.666666666666667 23.1 23 1 abnormal placenta size 0.00364198833904194 0.0210195962723128 1.55581761006289 0.666666666666667 23.1 23 1 myocarditis 0.00947068636640435 0.0449157909178853 1.55581761006289 0.666666666666667 23.1 23 1 abnormal embryonic growth/weight/body size 0.00947068636640435 0.0449157909178853 1.55581761006289 0.666666666666667 23.1 23 1 increased growth rate 0.00947068636640435 0.0449157909178853 1.55581761006289 0.666666666666667 23.1 23 1 abnormal corticospinal tract morphology 0.00947068636640435 0.0449157909178853 1.55581761006289 0.666666666666667 23.1 23 1 decreased synaptic depression 0.00947068636640435 0.0449157909178853 1.55581761006289 0.666666666666667 23.1 23 1 dilated bile duct 0.00947068636640435 0.0449157909178853 1.55581761006289 0.666666666666667 23.1 23 1 abnormal B cell proliferation 0.00947068636640435 0.0449157909178853 1.55581761006289 0.666666666666667 23.1 23 1 abnormal fatty acid level 0.00947068636640435 0.0449157909178853 1.55581761006289 0.666666666666667 23.1 23 1 increased fibrosarcoma incidence 0.00947068636640435 0.0449157909178853 1.55581761006289 0.666666666666667 23.1 23 1 heart hyperplasia 0.0252638935760458 0.0974324577835875 1.55581761006289 0.666666666666667 23.1 23 1 abnormal cholinergic neuron morphology 0.0252638935760458 0.0974324577835875 1.55581761006289 0.666666666666667 23.1 23 1 abnormal kindling response 0.0252638935760458 0.0974324577835875 1.55581761006289 0.666666666666667 23.1 23 1 abnormal germ cell morphology 0.0252638935760458 0.0974324577835875 1.55581761006289 0.666666666666667 23.1 23 1 abnormal posterior semicircular canal morphology 0.0252638935760458 0.0974324577835875 1.55581761006289 0.666666666666667 23.1 23 1 pancreas cysts 0.0252638935760458 0.0974324577835875 1.55581761006289 0.666666666666667 23.1 23 1 abnormal artery development 0.0252638935760458 0.0974324577835875 1.55581761006289 0.666666666666667 23.1 23 1 premature bone ossification 0.0252638935760458 0.0974324577835875 1.55581761006289 0.666666666666667 23.1 23 1 abnormal thymus physiology 0.0252638935760458 0.0974324577835875 1.55581761006289 0.666666666666667 23.1 23 1 small scapula 0.0252638935760458 0.0974324577835875 1.55581761006289 0.666666666666667 23.1 23 1 abnormal stria vascularis vasculature morphology 0.0252638935760458 0.0974324577835875 1.55581761006289 0.666666666666667 23.1 23 1 liver hyperplasia 0.0252638935760458 0.0974324577835875 1.55581761006289 0.666666666666667 23.1 23 1 abnormal inguinal fat pad morphology 0.0252638935760458 0.0974324577835875 1.55581761006289 0.666666666666667 23.1 23 1 abnormal liver vasculature morphology 0.0252638935760458 0.0974324577835875 1.55581761006289 0.666666666666667 23.1 23 1 abnormal hyoid bone lesser horn morphology 0.0252638935760458 0.0974324577835875 1.55581761006289 0.666666666666667 23.1 23 1 prolonged RR interval 0.0252638935760458 0.0974324577835875 1.55581761006289 0.666666666666667 23.1 23 1 abnormal pulmonary alveolar parenchyma morphology 0.0252638935760458 0.0974324577835875 1.55581761006289 0.666666666666667 23.1 23 1 decreased pancreatic beta cell proliferation 0.0252638935760458 0.0974324577835875 1.55581761006289 0.666666666666667 23.1 23 1 abnormal infrahyoid muscle connection 0.0252638935760458 0.0974324577835875 1.55581761006289 0.666666666666667 23.1 23 1 abnormal muscle physiology 1.67671981518056e-12 1.02983717043497e-10 1.54707706169175 0.662921348314607 23.1 23 1 decreased bone trabecula number 3.81608705614044e-07 7.47442248200736e-06 1.53926635889201 0.659574468085106 23.1 23 1 muscular atrophy 9.2856919209237e-07 1.64986847523555e-05 1.538137864494 0.659090909090909 23.1 23 1 abnormal compact bone morphology 5.53198069524555e-06 7.77705729477278e-05 1.53534632571996 0.657894736842105 23.1 23 1 decreased bone marrow cell number 3.00524321698736e-10 1.19608680036097e-08 1.53450504006203 0.657534246575342 23.1 23 1 astrocytosis 3.00524321698736e-10 1.19608680036097e-08 1.53450504006203 0.657534246575342 23.1 23 1 abnormal kidney morphology 1.67415516786662e-22 3.96615331435068e-20 1.53359164420485 0.657142857142857 23.1 23 1 increased circulating serum albumin level 1.35534248539805e-05 0.000173337502952579 1.53359164420485 0.657142857142857 23.1 23 1 abnormal spongiotrophoblast layer morphology 3.33095691360597e-05 0.000389237921587063 1.53150795990566 0.65625 23.1 23 1 abnormal long bone morphology 1.01644286541313e-08 2.88960186024589e-07 1.53031240334055 0.655737704918033 23.1 23 1 abnormal blood vessel morphology 1.03317014585616e-18 1.65807144375304e-16 1.52899316851008 0.655172413793103 23.1 23 1 abnormal head morphology 5.94181764967042e-08 1.37490896777257e-06 1.52753001715266 0.654545454545455 23.1 23 1 distended pericardium 1.43899028183786e-07 3.02066525406892e-06 1.52589804063861 0.653846153846154 23.1 23 1 kinked neural tube 1.43899028183786e-07 3.02066525406892e-06 1.52589804063861 0.653846153846154 23.1 23 1 heart inflammation 0.00020361081947262 0.00188735485448296 1.52589804063861 0.653846153846154 23.1 23 1 increased leukemia incidence 0.00020361081947262 0.00188735485448296 1.52589804063861 0.653846153846154 23.1 23 1 increased thymocyte apoptosis 0.00020361081947262 0.00188735485448296 1.52589804063861 0.653846153846154 23.1 23 1 abnormal neurocranium morphology 2.75966400787921e-10 1.12535479009828e-08 1.52470125786164 0.653333333333333 23.1 23 1 abnormal sternum morphology 1.59910157454523e-09 5.44899337901543e-08 1.521995488105 0.652173913043478 23.1 23 1 abnormal cell cycle 6.38111918658318e-15 5.98982414212289e-13 1.521995488105 0.652173913043478 23.1 23 1 abnormal skeleton morphology 6.38111918658318e-15 5.98982414212289e-13 1.521995488105 0.652173913043478 23.1 23 1 failure to gastrulate 8.47415310051094e-07 1.53305133363789e-05 1.521995488105 0.652173913043478 23.1 23 1 abnormal allantois morphology 8.47415310051094e-07 1.53305133363789e-05 1.521995488105 0.652173913043478 23.1 23 1 abnormal myelin sheath morphology 8.47415310051094e-07 1.53305133363789e-05 1.521995488105 0.652173913043478 23.1 23 1 abnormal blood vessel physiology 0.000507365660039538 0.00417213910528381 1.521995488105 0.652173913043478 23.1 23 1 dilated heart 0.000507365660039538 0.00417213910528381 1.521995488105 0.652173913043478 23.1 23 1 abnormal chondrocyte physiology 0.000507365660039538 0.00417213910528381 1.521995488105 0.652173913043478 23.1 23 1 abnormal basicranium morphology 0.000507365660039538 0.00417213910528381 1.521995488105 0.652173913043478 23.1 23 1 decreased effector memory CD8-positive, alpha-beta T cell number 0.000507365660039538 0.00417213910528381 1.521995488105 0.652173913043478 23.1 23 1 abnormal vasculogenesis 2.06138981008426e-06 3.29756086982933e-05 1.51963580517771 0.651162790697674 23.1 23 1 abnormal blood circulation 2.06138981008426e-06 3.29756086982933e-05 1.51963580517771 0.651162790697674 23.1 23 1 delayed endochondral bone ossification 2.06138981008426e-06 3.29756086982933e-05 1.51963580517771 0.651162790697674 23.1 23 1 pale yolk sac 4.36910450779134e-11 2.17362949262619e-09 1.51832802909752 0.650602409638554 23.1 23 1 abnormal basioccipital bone morphology 0.0012732324748849 0.00893472791600045 1.51692216981132 0.65 23.1 23 1 abnormal vascular regression 0.0012732324748849 0.00893472791600045 1.51692216981132 0.65 23.1 23 1 small gonad 0.0012732324748849 0.00893472791600045 1.51692216981132 0.65 23.1 23 1 abnormal circulating enzyme level 0.0012732324748849 0.00893472791600045 1.51692216981132 0.65 23.1 23 1 brain inflammation 0.0012732324748849 0.00893472791600045 1.51692216981132 0.65 23.1 23 1 anencephaly 0.0012732324748849 0.00893472791600045 1.51692216981132 0.65 23.1 23 1 abnormal hyoid bone morphology 0.0012732324748849 0.00893472791600045 1.51692216981132 0.65 23.1 23 1 abnormal lens epithelium morphology 0.0012732324748849 0.00893472791600045 1.51692216981132 0.65 23.1 23 1 abnormal physiological neovascularization 0.0012732324748849 0.00893472791600045 1.51692216981132 0.65 23.1 23 1 intracranial hemorrhage 2.24153434602111e-08 5.74826462446136e-07 1.51692216981132 0.65 23.1 23 1 abnormal cell morphology 1.39809442544731e-14 1.2880592160371e-12 1.51487504137703 0.649122807017544 23.1 23 1 cleft palate 1.63117205967805e-16 1.93216214211865e-14 1.51424996399251 0.648854961832061 23.1 23 1 increased cell proliferation 1.30862082701325e-07 2.79415820360126e-06 1.51260045422781 0.648148148148148 23.1 23 1 abnormal extraembryonic tissue morphology 4.58813312475282e-13 3.08458949941153e-11 1.51005826859046 0.647058823529412 23.1 23 1 abnormal embryonic-extraembryonic boundary morphology 0.00322469805507152 0.0189184821037509 1.51005826859046 0.647058823529412 23.1 23 1 common atrium 0.00322469805507152 0.0189184821037509 1.51005826859046 0.647058823529412 23.1 23 1 abnormal cardiovascular system physiology 1.48823824863713e-16 1.85099632174243e-14 1.50902610299333 0.646616541353383 23.1 23 1 abnormal developmental patterning 9.55239306387684e-11 4.35992252227406e-09 1.50838414634146 0.646341463414634 23.1 23 1 thymus atrophy 7.67304134935451e-07 1.40343311444995e-05 1.50719830974843 0.645833333333333 23.1 23 1 abnormal nose morphology 7.38242708966953e-05 0.000783103939682429 1.50562994522215 0.645161290322581 23.1 23 1 abnormal myocardial trabeculae morphology 1.86167500632792e-06 3.00708868716928e-05 1.5039570230608 0.644444444444444 23.1 23 1 polydactyly 2.38593019467444e-12 1.43012080945848e-10 1.50025269541779 0.642857142857143 23.1 23 1 abnormal muscle morphology 4.52393204709959e-06 6.46740285468979e-05 1.50025269541779 0.642857142857143 23.1 23 1 lymphoid hyperplasia 0.000182002006637391 0.0017148863314792 1.50025269541779 0.642857142857143 23.1 23 1 absent atrioventricular cushions 0.00826950081708944 0.039903750305548 1.50025269541779 0.642857142857143 23.1 23 1 megacephaly 0.00826950081708944 0.039903750305548 1.50025269541779 0.642857142857143 23.1 23 1 translucent skin 0.00826950081708944 0.039903750305548 1.50025269541779 0.642857142857143 23.1 23 1 irregularly shaped pupil 0.00826950081708944 0.039903750305548 1.50025269541779 0.642857142857143 23.1 23 1 increased aggression towards males 0.00826950081708944 0.039903750305548 1.50025269541779 0.642857142857143 23.1 23 1 skeletal muscle necrosis 0.00826950081708944 0.039903750305548 1.50025269541779 0.642857142857143 23.1 23 1 split sternum 0.00826950081708944 0.039903750305548 1.50025269541779 0.642857142857143 23.1 23 1 abnormal squamosal bone morphology 0.00826950081708944 0.039903750305548 1.50025269541779 0.642857142857143 23.1 23 1 increased pulmonary respiratory rate 0.00826950081708944 0.039903750305548 1.50025269541779 0.642857142857143 23.1 23 1 decreased tongue size 0.00826950081708944 0.039903750305548 1.50025269541779 0.642857142857143 23.1 23 1 testis degeneration 0.00826950081708944 0.039903750305548 1.50025269541779 0.642857142857143 23.1 23 1 multiple persisting craniopharyngeal ducts 0.00826950081708944 0.039903750305548 1.50025269541779 0.642857142857143 23.1 23 1 decreased response to antigen 0.00826950081708944 0.039903750305548 1.50025269541779 0.642857142857143 23.1 23 1 rib fusion 7.62914873001073e-09 2.23264793716491e-07 1.49776471416502 0.641791044776119 23.1 23 1 enlarged kidney 2.85505367702942e-07 5.68155681728855e-06 1.49710751156995 0.641509433962264 23.1 23 1 increased vascular permeability 1.1012843514223e-05 0.000144181306534893 1.49597847121432 0.641025641025641 23.1 23 1 decreased trabecular bone volume 1.1012843514223e-05 0.000144181306534893 1.49597847121432 0.641025641025641 23.1 23 1 spontaneous skin ulceration 0.00045066843459615 0.00375557028830125 1.49358490566038 0.64 23.1 23 1 short snout 3.41208363877181e-13 2.42501658612711e-11 1.49099187631027 0.638888888888889 23.1 23 1 abnormal digit morphology 2.86050622168249e-09 9.13264898203512e-08 1.49099187631027 0.638888888888889 23.1 23 1 perinatal lethality, incomplete penetrance 9.39659406242172e-26 2.59711419225267e-23 1.48697612289197 0.63716814159292 23.1 23 1 decreased circulating serum albumin level 4.63904300744729e-12 2.62264079114207e-10 1.48509862778731 0.636363636363636 23.1 23 1 omphalocele 4.0438258915701e-06 5.88246602647989e-05 1.48509862778731 0.636363636363636 23.1 23 1 enlarged pericardium 6.56843526508336e-05 0.000704266496633399 1.48509862778731 0.636363636363636 23.1 23 1 increased cardiomyocyte apoptosis 6.56843526508336e-05 0.000704266496633399 1.48509862778731 0.636363636363636 23.1 23 1 abnormal germ layer development 0.00112196762073451 0.00813671853229475 1.48509862778731 0.636363636363636 23.1 23 1 intracerebral hemorrhage 0.00112196762073451 0.00813671853229475 1.48509862778731 0.636363636363636 23.1 23 1 abnormal cochlear sensory epithelium morphology 0.00112196762073451 0.00813671853229475 1.48509862778731 0.636363636363636 23.1 23 1 prolonged PR interval 0.00112196762073451 0.00813671853229475 1.48509862778731 0.636363636363636 23.1 23 1 abnormal circulating lipid level 0.00112196762073451 0.00813671853229475 1.48509862778731 0.636363636363636 23.1 23 1 abnormal occipital bone morphology 0.00112196762073451 0.00813671853229475 1.48509862778731 0.636363636363636 23.1 23 1 increased circulating creatine kinase level 0.00112196762073451 0.00813671853229475 1.48509862778731 0.636363636363636 23.1 23 1 abnormal glossopharyngeal ganglion morphology 0.0215869824633295 0.0850318588717848 1.48509862778731 0.636363636363636 23.1 23 1 failure of somite differentiation 0.0215869824633295 0.0850318588717848 1.48509862778731 0.636363636363636 23.1 23 1 vasculitis 0.0215869824633295 0.0850318588717848 1.48509862778731 0.636363636363636 23.1 23 1 abnormal fear/anxiety-related behavior 0.0215869824633295 0.0850318588717848 1.48509862778731 0.636363636363636 23.1 23 1 retinal detachment 0.0215869824633295 0.0850318588717848 1.48509862778731 0.636363636363636 23.1 23 1 rectal hemorrhage 0.0215869824633295 0.0850318588717848 1.48509862778731 0.636363636363636 23.1 23 1 dilated renal glomerular capsule 0.0215869824633295 0.0850318588717848 1.48509862778731 0.636363636363636 23.1 23 1 pharyngeal arch hypoplasia 0.0215869824633295 0.0850318588717848 1.48509862778731 0.636363636363636 23.1 23 1 abnormal spinal cord ventral horn morphology 0.0215869824633295 0.0850318588717848 1.48509862778731 0.636363636363636 23.1 23 1 increased glycogen level 0.0215869824633295 0.0850318588717848 1.48509862778731 0.636363636363636 23.1 23 1 abnormal palate development 0.0215869824633295 0.0850318588717848 1.48509862778731 0.636363636363636 23.1 23 1 palatal shelf hypoplasia 0.0215869824633295 0.0850318588717848 1.48509862778731 0.636363636363636 23.1 23 1 abnormal palatal shelf elevation 0.0215869824633295 0.0850318588717848 1.48509862778731 0.636363636363636 23.1 23 1 decreased palatine bone horizontal plate size 0.0215869824633295 0.0850318588717848 1.48509862778731 0.636363636363636 23.1 23 1 abnormal pulmonary alveolar sac morphology 0.0215869824633295 0.0850318588717848 1.48509862778731 0.636363636363636 23.1 23 1 increased subcutaneous adipose tissue amount 0.0215869824633295 0.0850318588717848 1.48509862778731 0.636363636363636 23.1 23 1 decreased core body temperature 0.0215869824633295 0.0850318588717848 1.48509862778731 0.636363636363636 23.1 23 1 decreased embryonic cilium length 0.0215869824633295 0.0850318588717848 1.48509862778731 0.636363636363636 23.1 23 1 reduced sympathetic cervical ganglion size 0.0215869824633295 0.0850318588717848 1.48509862778731 0.636363636363636 23.1 23 1 abnormal snout morphology 6.1678574140403e-07 1.1407096890279e-05 1.48101868650218 0.634615384615385 23.1 23 1 decreased kidney weight 6.1678574140403e-07 1.1407096890279e-05 1.48101868650218 0.634615384615385 23.1 23 1 abnormal cranium morphology 1.22080238605532e-15 1.23948813686229e-13 1.48034884539566 0.634328358208955 23.1 23 1 pallor 5.75868891796056e-20 1.14597909467415e-17 1.48024932614555 0.634285714285714 23.1 23 1 palatal shelves fail to meet at midline 9.80839865280662e-06 0.000129778678983279 1.47992406810861 0.634146341463415 23.1 23 1 embryonic lethality during organogenesis, complete penetrance 8.60811201850495e-61 1.4275119097354e-57 1.47941585242588 0.633928571428571 23.1 23 1 increased metastatic potential 0.000161046163744993 0.00153284188276006 1.47802672955975 0.633333333333333 23.1 23 1 disorganized myocardium 0.000161046163744993 0.00153284188276006 1.47802672955975 0.633333333333333 23.1 23 1 abnormal microglial cell physiology 0.000161046163744993 0.00153284188276006 1.47802672955975 0.633333333333333 23.1 23 1 abnormal cellular respiration 0.000161046163744993 0.00153284188276006 1.47802672955975 0.633333333333333 23.1 23 1 abnormal eye morphology 4.60460912607341e-16 4.7724855004615e-14 1.47746708293742 0.633093525179856 23.1 23 1 abnormal visceral yolk sac morphology 9.59837772317111e-10 3.43539058796952e-08 1.47704203486984 0.632911392405063 23.1 23 1 absent kidney 1.48780936839288e-06 2.45908691287527e-05 1.47643916056989 0.63265306122449 23.1 23 1 abnormal facial morphology 2.28149908366435e-07 4.59532710171261e-06 1.47393247269116 0.631578947368421 23.1 23 1 kyphoscoliosis 0.00281220347831033 0.0165963372533735 1.47393247269116 0.631578947368421 23.1 23 1 abnormal triglyceride level 0.00281220347831033 0.0165963372533735 1.47393247269116 0.631578947368421 23.1 23 1 enlarged adrenal glands 0.00281220347831033 0.0165963372533735 1.47393247269116 0.631578947368421 23.1 23 1 delayed sexual maturation 0.00281220347831033 0.0165963372533735 1.47393247269116 0.631578947368421 23.1 23 1 abnormal sternebra morphology 0.00281220347831033 0.0165963372533735 1.47393247269116 0.631578947368421 23.1 23 1 decreased liver regeneration 0.00281220347831033 0.0165963372533735 1.47393247269116 0.631578947368421 23.1 23 1 decreased liver glycogen level 0.00281220347831033 0.0165963372533735 1.47393247269116 0.631578947368421 23.1 23 1 thin interventricular septum 0.00281220347831033 0.0165963372533735 1.47393247269116 0.631578947368421 23.1 23 1 embryonic lethality during organogenesis, incomplete penetrance 3.10267108922419e-25 8.12409929941597e-23 1.47126230516817 0.630434782608696 23.1 23 1 abnormal chondrocyte morphology 5.483989522057e-07 1.02567097264036e-05 1.46938329839273 0.62962962962963 23.1 23 1 neurodegeneration 5.483989522057e-07 1.02567097264036e-05 1.46938329839273 0.62962962962963 23.1 23 1 rectal prolapse 0.000396137634066494 0.00334031310081493 1.46938329839273 0.62962962962963 23.1 23 1 abnormal eye muscle morphology 0.000396137634066494 0.00334031310081493 1.46938329839273 0.62962962962963 23.1 23 1 abnormal skin appearance 0.000396137634066494 0.00334031310081493 1.46938329839273 0.62962962962963 23.1 23 1 prenatal lethality 8.44891927056696e-08 1.87648988263708e-06 1.4679891965916 0.629032258064516 23.1 23 1 abnormal liver development 5.79770458421783e-05 0.000635321152125192 1.46691374663073 0.628571428571429 23.1 23 1 abnormal heart ventricle morphology 2.04287655720267e-09 6.91381691978454e-08 1.46605890179003 0.628205128205128 23.1 23 1 cleft secondary palate 5.0195777805745e-11 2.45018083813411e-09 1.46478572862304 0.627659574468085 23.1 23 1 abnormal response to novel object 1.31878702104282e-06 2.20166625157316e-05 1.46429892711802 0.627450980392157 23.1 23 1 abnormal trophoblast layer morphology 1.31878702104282e-06 2.20166625157316e-05 1.46429892711802 0.627450980392157 23.1 23 1 decreased white adipose tissue amount 3.13213832697638e-08 7.75243192871019e-07 1.4629329766263 0.626865671641791 23.1 23 1 abnormal heart development 1.95959632832069e-17 2.78542620954155e-15 1.46227161452114 0.626582278481013 23.1 23 1 small spleen 1.19400983465556e-10 5.30374904233164e-09 1.46178467758656 0.626373626373626 23.1 23 1 abnormal embryonic tissue morphology 2.92896764497133e-16 3.16774218124616e-14 1.46056347067129 0.625850340136054 23.1 23 1 small kidney 2.83947116098449e-10 1.14848528665836e-08 1.45857900943396 0.625 23.1 23 1 abnormal forebrain development 1.16225032040578e-08 3.24842435057235e-07 1.45857900943396 0.625 23.1 23 1 decreased lymphocyte cell number 2.76688626364631e-14 2.37332054511041e-12 1.45857900943396 0.625 23.1 23 1 abnormal osteoclast physiology 7.48630382952525e-08 1.70065577862503e-06 1.45857900943396 0.625 23.1 23 1 vertebral transformation 3.17296501494761e-06 4.7403906754848e-05 1.45857900943396 0.625 23.1 23 1 scoliosis 0.000141348773831089 0.00137345732384701 1.45857900943396 0.625 23.1 23 1 kidney cortex cysts 0.000141348773831089 0.00137345732384701 1.45857900943396 0.625 23.1 23 1 polydipsia 0.000141348773831089 0.00137345732384701 1.45857900943396 0.625 23.1 23 1 abnormal diaphragm morphology 0.000141348773831089 0.00137345732384701 1.45857900943396 0.625 23.1 23 1 abnormal heart atrium morphology 0.000141348773831089 0.00137345732384701 1.45857900943396 0.625 23.1 23 1 impaired muscle relaxation 0.00711067802056521 0.0360975746452162 1.45857900943396 0.625 23.1 23 1 increased pancreatic beta cell number 0.00711067802056521 0.0360975746452162 1.45857900943396 0.625 23.1 23 1 small pancreas 0.00711067802056521 0.0360975746452162 1.45857900943396 0.625 23.1 23 1 abnormal amnion morphology 0.00711067802056521 0.0360975746452162 1.45857900943396 0.625 23.1 23 1 abnormal level of surface class II molecules 0.00711067802056521 0.0360975746452162 1.45857900943396 0.625 23.1 23 1 impaired behavioral response to addictive substance 0.00711067802056521 0.0360975746452162 1.45857900943396 0.625 23.1 23 1 decreased liver cholesterol level 0.00711067802056521 0.0360975746452162 1.45857900943396 0.625 23.1 23 1 decreased skeletal muscle weight 0.00711067802056521 0.0360975746452162 1.45857900943396 0.625 23.1 23 1 dilated respiratory conducting tubes 0.00711067802056521 0.0360975746452162 1.45857900943396 0.625 23.1 23 1 embryonic lethality between somite formation and embryo turning, incomplete penetrance 0.00711067802056521 0.0360975746452162 1.45857900943396 0.625 23.1 23 1 decreased adipocyte glucose uptake 0.00711067802056521 0.0360975746452162 1.45857900943396 0.625 23.1 23 1 abnormal exoccipital bone morphology 0.057918354713812 0.175590380683251 1.45857900943396 0.625 23.1 23 1 abnormal hypoglossal nerve morphology 0.057918354713812 0.175590380683251 1.45857900943396 0.625 23.1 23 1 abnormal vagus ganglion morphology 0.057918354713812 0.175590380683251 1.45857900943396 0.625 23.1 23 1 dermal cysts 0.057918354713812 0.175590380683251 1.45857900943396 0.625 23.1 23 1 dry eyes 0.057918354713812 0.175590380683251 1.45857900943396 0.625 23.1 23 1 abnormal circulating calcium level 0.057918354713812 0.175590380683251 1.45857900943396 0.625 23.1 23 1 abnormal urination 0.057918354713812 0.175590380683251 1.45857900943396 0.625 23.1 23 1 abnormal hepatobiliary system morphology 0.057918354713812 0.175590380683251 1.45857900943396 0.625 23.1 23 1 coarse hair 0.057918354713812 0.175590380683251 1.45857900943396 0.625 23.1 23 1 altered response to CNS ischemic injury 0.057918354713812 0.175590380683251 1.45857900943396 0.625 23.1 23 1 abnormal cellular cholesterol metabolism 0.057918354713812 0.175590380683251 1.45857900943396 0.625 23.1 23 1 decreased susceptibility to age related obesity 0.057918354713812 0.175590380683251 1.45857900943396 0.625 23.1 23 1 loss of GABAergic neurons 0.057918354713812 0.175590380683251 1.45857900943396 0.625 23.1 23 1 abnormal perineum morphology 0.057918354713812 0.175590380683251 1.45857900943396 0.625 23.1 23 1 hair follicle degeneration 0.057918354713812 0.175590380683251 1.45857900943396 0.625 23.1 23 1 abnormal ovary development 0.057918354713812 0.175590380683251 1.45857900943396 0.625 23.1 23 1 elevated level of mitotic sister chromatid exchange 0.057918354713812 0.175590380683251 1.45857900943396 0.625 23.1 23 1 abnormal lateral ganglionic eminence morphology 0.057918354713812 0.175590380683251 1.45857900943396 0.625 23.1 23 1 long femur 0.057918354713812 0.175590380683251 1.45857900943396 0.625 23.1 23 1 small frontal bone 0.057918354713812 0.175590380683251 1.45857900943396 0.625 23.1 23 1 abnormal kidney epithelium morphology 0.057918354713812 0.175590380683251 1.45857900943396 0.625 23.1 23 1 increased circulating prolactin level 0.057918354713812 0.175590380683251 1.45857900943396 0.625 23.1 23 1 abnormal canal of Schlemm morphology 0.057918354713812 0.175590380683251 1.45857900943396 0.625 23.1 23 1 abnormal vertebral body development 0.057918354713812 0.175590380683251 1.45857900943396 0.625 23.1 23 1 ocular hypertension 0.057918354713812 0.175590380683251 1.45857900943396 0.625 23.1 23 1 stomach epithelial hyperplasia 0.057918354713812 0.175590380683251 1.45857900943396 0.625 23.1 23 1 enlarged inguinal lymph nodes 0.057918354713812 0.175590380683251 1.45857900943396 0.625 23.1 23 1 abnormal frontonasal prominence morphology 0.057918354713812 0.175590380683251 1.45857900943396 0.625 23.1 23 1 abnormal olfactory bulb glomerular layer morphology 0.057918354713812 0.175590380683251 1.45857900943396 0.625 23.1 23 1 abnormal cerebellum deep nucleus morphology 0.057918354713812 0.175590380683251 1.45857900943396 0.625 23.1 23 1 pleural effusion 0.057918354713812 0.175590380683251 1.45857900943396 0.625 23.1 23 1 heart right ventricle hypoplasia 0.057918354713812 0.175590380683251 1.45857900943396 0.625 23.1 23 1 sinoatrial block 0.057918354713812 0.175590380683251 1.45857900943396 0.625 23.1 23 1 increased heart right ventricle size 0.057918354713812 0.175590380683251 1.45857900943396 0.625 23.1 23 1 delayed suture closure 0.057918354713812 0.175590380683251 1.45857900943396 0.625 23.1 23 1 lung situs inversus 0.057918354713812 0.175590380683251 1.45857900943396 0.625 23.1 23 1 abnormal anterior commissure pars posterior morphology 0.057918354713812 0.175590380683251 1.45857900943396 0.625 23.1 23 1 decreased lung compliance 0.057918354713812 0.175590380683251 1.45857900943396 0.625 23.1 23 1 abnormal pulmonary acinus morphology 0.057918354713812 0.175590380683251 1.45857900943396 0.625 23.1 23 1 abnormal maxillary prominence morphology 0.057918354713812 0.175590380683251 1.45857900943396 0.625 23.1 23 1 lethality during fetal growth through weaning, incomplete penetrance 0.057918354713812 0.175590380683251 1.45857900943396 0.625 23.1 23 1 absent Reichert's membrane 0.057918354713812 0.175590380683251 1.45857900943396 0.625 23.1 23 1 embryo cyst 0.057918354713812 0.175590380683251 1.45857900943396 0.625 23.1 23 1 increased osteoclast cell number 1.78931257737643e-07 3.69370542425217e-06 1.45379678317352 0.622950819672131 23.1 23 1 decreased birth body size 9.824248744116e-13 6.18678955721229e-11 1.45346118834823 0.62280701754386 23.1 23 1 thin ventricular wall 2.51458881382412e-10 1.03389085527066e-08 1.4520964360587 0.622222222222222 23.1 23 1 cardiomyopathy 7.63795676138075e-06 0.000103539059639971 1.4520964360587 0.622222222222222 23.1 23 1 lordosis 0.000345366167314603 0.00295730926401058 1.44851984385166 0.620689655172414 23.1 23 1 short limbs 5.96758675998476e-10 2.23223640082137e-08 1.44851984385166 0.620689655172414 23.1 23 1 abnormal myocardium layer morphology 3.81183990584908e-09 1.18524397072495e-07 1.44750119417244 0.620253164556962 23.1 23 1 abnormal hematopoietic system physiology 0.00242664367111662 0.0145117957475953 1.44468778077269 0.619047619047619 23.1 23 1 abnormal rostral-caudal axis patterning 1.02198662572825e-06 1.77775645559372e-05 1.44266723842196 0.618181818181818 23.1 23 1 decreased circulating total protein level 1.02198662572825e-06 1.77775645559372e-05 1.44266723842196 0.618181818181818 23.1 23 1 abnormal skeleton development 3.3565424939929e-09 1.05145878909826e-07 1.44057186116935 0.617283950617284 23.1 23 1 decreased embryo size 3.38350926981312e-47 2.80549310288672e-44 1.44027048630299 0.617154811715481 23.1 23 1 muscular ventricular septal defect 3.75425370926216e-07 7.38237636505109e-06 1.43913128930818 0.616666666666667 23.1 23 1 eyelids open at birth 2.44198906846488e-06 3.84458722013062e-05 1.43613933236575 0.615384615384615 23.1 23 1 abnormal nasal bone morphology 0.000845960618793798 0.006338334455571 1.43613933236575 0.615384615384615 23.1 23 1 ventricular hypoplasia 0.000845960618793798 0.006338334455571 1.43613933236575 0.615384615384615 23.1 23 1 abnormal kidney cortex morphology 0.000845960618793798 0.006338334455571 1.43613933236575 0.615384615384615 23.1 23 1 thick skin 0.000845960618793798 0.006338334455571 1.43613933236575 0.615384615384615 23.1 23 1 short premaxilla 0.0181904751144321 0.0743001754468799 1.43613933236575 0.615384615384615 23.1 23 1 absent teeth 0.0181904751144321 0.0743001754468799 1.43613933236575 0.615384615384615 23.1 23 1 absent trabeculae carneae 0.0181904751144321 0.0743001754468799 1.43613933236575 0.615384615384615 23.1 23 1 abnormal renal/urinary system morphology 0.0181904751144321 0.0743001754468799 1.43613933236575 0.615384615384615 23.1 23 1 small trigeminal ganglion 0.0181904751144321 0.0743001754468799 1.43613933236575 0.615384615384615 23.1 23 1 excessive scratching 0.0181904751144321 0.0743001754468799 1.43613933236575 0.615384615384615 23.1 23 1 lymphoid hypoplasia 0.0181904751144321 0.0743001754468799 1.43613933236575 0.615384615384615 23.1 23 1 abnormal tail bud morphology 0.0181904751144321 0.0743001754468799 1.43613933236575 0.615384615384615 23.1 23 1 axonal dystrophy 0.0181904751144321 0.0743001754468799 1.43613933236575 0.615384615384615 23.1 23 1 small otic vesicle 0.0181904751144321 0.0743001754468799 1.43613933236575 0.615384615384615 23.1 23 1 abnormal liver morphology 2.76078403831621e-18 4.16209108806761e-16 1.43413355117529 0.614525139664804 23.1 23 1 abnormal craniofacial bone morphology 8.94390104540649e-07 1.60635045851615e-05 1.4329899040053 0.614035087719298 23.1 23 1 abnormal limb morphology 1.88395994846137e-08 4.90717316418602e-07 1.43135220125786 0.613333333333333 23.1 23 1 increased tumor incidence 5.23662905445301e-13 3.42792494025049e-11 1.43034844796105 0.612903225806452 23.1 23 1 increased lung adenoma incidence 0.000299147494088129 0.00258378260952854 1.43034844796105 0.612903225806452 23.1 23 1 abnormal podocyte morphology 0.000299147494088129 0.00258378260952854 1.43034844796105 0.612903225806452 23.1 23 1 abnormal long bone hypertrophic chondrocyte zone 5.83373708845513e-06 8.17544845494768e-05 1.42881209087409 0.612244897959184 23.1 23 1 abnormal neural tube morphology 2.2535645612323e-16 2.54806447548424e-14 1.42616614255765 0.611111111111111 23.1 23 1 abnormal long bone epiphyseal plate proliferative zone 2.12982599570458e-06 3.39611677199688e-05 1.42616614255765 0.611111111111111 23.1 23 1 renal hypoplasia 0.000106869189882611 0.00107192382997176 1.42616614255765 0.611111111111111 23.1 23 1 short radius 0.000106869189882611 0.00107192382997176 1.42616614255765 0.611111111111111 23.1 23 1 abnormal trophoblast giant cell morphology 0.000106869189882611 0.00107192382997176 1.42616614255765 0.611111111111111 23.1 23 1 abnormal heart shape 0.00605421420890638 0.0313747038430305 1.42616614255765 0.611111111111111 23.1 23 1 cortical renal glomerulopathies 0.00605421420890638 0.0313747038430305 1.42616614255765 0.611111111111111 23.1 23 1 right pulmonary isomerism 0.00605421420890638 0.0313747038430305 1.42616614255765 0.611111111111111 23.1 23 1 abnormal mammary gland morphology 0.00605421420890638 0.0313747038430305 1.42616614255765 0.611111111111111 23.1 23 1 thick dermal layer 0.00605421420890638 0.0313747038430305 1.42616614255765 0.611111111111111 23.1 23 1 abnormal metacarpal bone morphology 0.00605421420890638 0.0313747038430305 1.42616614255765 0.611111111111111 23.1 23 1 absent allantois 0.00605421420890638 0.0313747038430305 1.42616614255765 0.611111111111111 23.1 23 1 decreased cellular sensitivity to gamma-irradiation 0.00605421420890638 0.0313747038430305 1.42616614255765 0.611111111111111 23.1 23 1 abnormal eye anterior chamber morphology 0.00605421420890638 0.0313747038430305 1.42616614255765 0.611111111111111 23.1 23 1 decreased lactate dehydrogenase level 0.00605421420890638 0.0313747038430305 1.42616614255765 0.611111111111111 23.1 23 1 decreased pulmonary respiratory rate 0.00605421420890638 0.0313747038430305 1.42616614255765 0.611111111111111 23.1 23 1 primary atelectasis 0.00605421420890638 0.0313747038430305 1.42616614255765 0.611111111111111 23.1 23 1 abnormal embryo size 7.77388291730445e-12 4.20381168625975e-10 1.42501878443814 0.610619469026549 23.1 23 1 lethality throughout fetal growth and development, complete penetrance 6.99072633161095e-19 1.15929544999215e-16 1.42480139026812 0.610526315789474 23.1 23 1 liver fibrosis 3.847178854069e-05 0.000444076909489403 1.42300391164289 0.609756097560976 23.1 23 1 short ulna 3.847178854069e-05 0.000444076909489403 1.42300391164289 0.609756097560976 23.1 23 1 abnormal nervous system physiology 6.80110616591441e-12 3.71818716213453e-10 1.42052912223134 0.608695652173913 23.1 23 1 abnormal postnatal growth 0.00207801511514891 0.0128904304212791 1.42052912223134 0.608695652173913 23.1 23 1 abnormal placenta morphology 1.43687933009482e-08 3.90627030995723e-07 1.41796035347504 0.607594936708861 23.1 23 1 shortened head 0.000727074512820562 0.00552743695519771 1.41690532345013 0.607142857142857 23.1 23 1 small superior cervical ganglion 0.000727074512820562 0.00552743695519771 1.41690532345013 0.607142857142857 23.1 23 1 absent corpus callosum 0.000727074512820562 0.00552743695519771 1.41690532345013 0.607142857142857 23.1 23 1 abnormal brainstem morphology 0.000727074512820562 0.00552743695519771 1.41690532345013 0.607142857142857 23.1 23 1 abnormal renal tubule epithelium morphology 0.000727074512820562 0.00552743695519771 1.41690532345013 0.607142857142857 23.1 23 1 myeloid hyperplasia 0.000257755575646868 0.00230221541982615 1.41437964551172 0.606060606060606 23.1 23 1 abnormal ovary morphology 9.17527154388263e-08 1.98465112742679e-06 1.41338360350784 0.605633802816901 23.1 23 1 abnormal skeletal muscle fiber morphology 9.17527154388263e-08 1.98465112742679e-06 1.41338360350784 0.605633802816901 23.1 23 1 incomplete somite formation 9.2251256767723e-05 0.000956145838373796 1.41251861966236 0.605263157894737 23.1 23 1 impaired branching involved in ureteric bud morphogenesis 9.2251256767723e-05 0.000956145838373796 1.41251861966236 0.605263157894737 23.1 23 1 abnormal lung morphology 5.18058518501458e-12 2.89588890960084e-10 1.4120025368638 0.605042016806723 23.1 23 1 decreased heart weight 1.25055670508667e-08 3.45639978211456e-07 1.41176042394596 0.604938271604938 23.1 23 1 prenatal lethality, complete penetrance 5.76717203941788e-26 1.68774593506494e-23 1.41030948825845 0.60431654676259 23.1 23 1 small heart 1.20560156468723e-05 0.000156549357354739 1.4099597091195 0.604166666666667 23.1 23 1 preweaning lethality, incomplete penetrance 1.87762907539205e-37 1.03791162778616e-34 1.40936534114499 0.603911980440098 23.1 23 1 abnormal mesoderm development 4.39031777010911e-06 6.29447576550226e-05 1.40904236383054 0.60377358490566 23.1 23 1 abnormal placenta development 4.39031777010911e-06 6.29447576550226e-05 1.40904236383054 0.60377358490566 23.1 23 1 abnormal embryonic neuroepithelium morphology 1.60465252660475e-06 2.60887134635902e-05 1.40828318152245 0.603448275862069 23.1 23 1 glomerulosclerosis 1.60465252660475e-06 2.60887134635902e-05 1.40828318152245 0.603448275862069 23.1 23 1 abnormal fertility/fecundity 7.96401020694816e-08 1.77764662359429e-06 1.40662962005686 0.602739726027397 23.1 23 1 small liver 2.93879632944061e-08 7.31025586948353e-07 1.40621976294146 0.602564102564103 23.1 23 1 abnormal cornea morphology 2.93879632944061e-08 7.31025586948353e-07 1.40621976294146 0.602564102564103 23.1 23 1 abnormal neural tube closure 1.08615437345894e-08 3.07023750452173e-07 1.40585928620141 0.602409638554217 23.1 23 1 cardiac hypertrophy 5.52463521460371e-10 2.09809619791248e-08 1.40499855602618 0.602040816326531 23.1 23 1 embryonic lethality, complete penetrance 3.77476690548541e-29 1.44457425806076e-26 1.40462530312888 0.601880877742947 23.1 23 1 abnormal heart morphology 1.71096043357019e-21 3.70088180739639e-19 1.40427693375807 0.601731601731602 23.1 23 1 spleen hyperplasia 6.89780841139155e-08 1.58140999293424e-06 1.4002358490566 0.6 23.1 23 1 abnormal erythropoiesis 1.78001672384325e-10 7.50473152637302e-09 1.4002358490566 0.6 23.1 23 1 decreased oocyte number 1.04001364479838e-05 0.000136880102721479 1.4002358490566 0.6 23.1 23 1 irregular heartbeat 2.8647987225337e-05 0.000339342229633456 1.4002358490566 0.6 23.1 23 1 abnormal dermal layer morphology 0.000221138628253427 0.0020186507808455 1.4002358490566 0.6 23.1 23 1 holoprosencephaly 0.000221138628253427 0.0020186507808455 1.4002358490566 0.6 23.1 23 1 abnormal heart tube morphology 0.000621846172669023 0.00491061064925141 1.4002358490566 0.6 23.1 23 1 emphysema 0.000621846172669023 0.00491061064925141 1.4002358490566 0.6 23.1 23 1 abnormal spleen marginal zone morphology 0.000621846172669023 0.00491061064925141 1.4002358490566 0.6 23.1 23 1 abnormal brain vasculature morphology 0.000621846172669023 0.00491061064925141 1.4002358490566 0.6 23.1 23 1 increased cellular sensitivity to ionizing radiation 0.00176943723216685 0.0111148361490279 1.4002358490566 0.6 23.1 23 1 decreased myocardial infarction size 0.00512065998344848 0.0272754640445998 1.4002358490566 0.6 23.1 23 1 dilated vasculature 0.00512065998344848 0.0272754640445998 1.4002358490566 0.6 23.1 23 1 abnormal neuron proliferation 0.00512065998344848 0.0272754640445998 1.4002358490566 0.6 23.1 23 1 abnormal fontanelle morphology 0.0152107695341607 0.0633251702363594 1.4002358490566 0.6 23.1 23 1 absent incisors 0.0152107695341607 0.0633251702363594 1.4002358490566 0.6 23.1 23 1 vagina atresia 0.0152107695341607 0.0633251702363594 1.4002358490566 0.6 23.1 23 1 abnormal prostate gland morphology 0.0152107695341607 0.0633251702363594 1.4002358490566 0.6 23.1 23 1 abnormal glial cell morphology 0.0152107695341607 0.0633251702363594 1.4002358490566 0.6 23.1 23 1 abnormal olfactory nerve morphology 0.0152107695341607 0.0633251702363594 1.4002358490566 0.6 23.1 23 1 bicuspid aortic valve 0.0152107695341607 0.0633251702363594 1.4002358490566 0.6 23.1 23 1 abnormal coronary vessel morphology 0.0152107695341607 0.0633251702363594 1.4002358490566 0.6 23.1 23 1 decreased trabecular bone mass 0.0152107695341607 0.0633251702363594 1.4002358490566 0.6 23.1 23 1 herniated liver 0.0152107695341607 0.0633251702363594 1.4002358490566 0.6 23.1 23 1 abnormal branching involved in lung morphogenesis 0.0152107695341607 0.0633251702363594 1.4002358490566 0.6 23.1 23 1 abnormal otic capsule morphology 0.0472980725388203 0.151615921959169 1.4002358490566 0.6 23.1 23 1 kidney hemorrhage 0.0472980725388203 0.151615921959169 1.4002358490566 0.6 23.1 23 1 abnormal prostate gland epithelium morphology 0.0472980725388203 0.151615921959169 1.4002358490566 0.6 23.1 23 1 abnormal mammary gland physiology 0.0472980725388203 0.151615921959169 1.4002358490566 0.6 23.1 23 1 decreased incidence of induced tumors 0.0472980725388203 0.151615921959169 1.4002358490566 0.6 23.1 23 1 abnormal gland morphology 0.0472980725388203 0.151615921959169 1.4002358490566 0.6 23.1 23 1 acrania 0.0472980725388203 0.151615921959169 1.4002358490566 0.6 23.1 23 1 abnormal hypaxial muscle morphology 0.0472980725388203 0.151615921959169 1.4002358490566 0.6 23.1 23 1 absent seminal vesicle 0.0472980725388203 0.151615921959169 1.4002358490566 0.6 23.1 23 1 abnormal glial cell physiology 0.0472980725388203 0.151615921959169 1.4002358490566 0.6 23.1 23 1 increased atrioventricular cushion size 0.0472980725388203 0.151615921959169 1.4002358490566 0.6 23.1 23 1 abnormal reproductive system development 0.0472980725388203 0.151615921959169 1.4002358490566 0.6 23.1 23 1 abnormal plasma membrane morphology 0.0472980725388203 0.151615921959169 1.4002358490566 0.6 23.1 23 1 abnormal corneal endothelium morphology 0.0472980725388203 0.151615921959169 1.4002358490566 0.6 23.1 23 1 vascular smooth muscle hyperplasia 0.0472980725388203 0.151615921959169 1.4002358490566 0.6 23.1 23 1 abnormal spinal cord dorsal column morphology 0.0472980725388203 0.151615921959169 1.4002358490566 0.6 23.1 23 1 abnormal cerebellar granule cell migration 0.0472980725388203 0.151615921959169 1.4002358490566 0.6 23.1 23 1 thick aortic valve 0.0472980725388203 0.151615921959169 1.4002358490566 0.6 23.1 23 1 fusion of atlas and odontoid process 0.0472980725388203 0.151615921959169 1.4002358490566 0.6 23.1 23 1 abnormal pulmonary interalveolar septum morphology 0.0472980725388203 0.151615921959169 1.4002358490566 0.6 23.1 23 1 lethality during fetal growth through weaning, complete penetrance 0.0472980725388203 0.151615921959169 1.4002358490566 0.6 23.1 23 1 abnormal learning/memory/conditioning 3.79158505066905e-06 5.5479810667878e-05 1.4002358490566 0.6 23.1 23 1 decreased compact bone thickness 4.39275190237585e-07 8.50347887716725e-06 1.39326950154886 0.597014925373134 23.1 23 1 increased hepatocellular carcinoma incidence 3.26615676279788e-06 4.83605056396412e-05 1.39204733531943 0.596491228070175 23.1 23 1 abnormal renal glomerulus morphology 1.3349252081344e-10 5.87721496501649e-09 1.39167171542323 0.596330275229358 23.1 23 1 liver hypoplasia 8.94704473944511e-06 0.000118697460209972 1.39125997822932 0.596153846153846 23.1 23 1 abnormal cell nucleus morphology 2.46052686706687e-05 0.000293859372999556 1.39030509835407 0.595744680851064 23.1 23 1 prenatal lethality, incomplete penetrance 9.18110971079963e-27 3.26257291508773e-24 1.38948842477656 0.595394736842105 23.1 23 1 abnormal somite development 5.14473692222972e-08 1.21881267562347e-06 1.38841951277765 0.594936708860759 23.1 23 1 decreased B cell proliferation 5.14473692222972e-08 1.21881267562347e-06 1.38841951277765 0.594936708860759 23.1 23 1 abnormal intestine morphology 1.39399594878097e-07 2.95111908305758e-06 1.38762111167772 0.594594594594595 23.1 23 1 abnormal branching of the mammary ductal tree 0.000189050928314313 0.00177458182710134 1.38762111167772 0.594594594594595 23.1 23 1 abnormal humerus morphology 0.000189050928314313 0.00177458182710134 1.38762111167772 0.594594594594595 23.1 23 1 abnormal pulmonary alveolus morphology 8.35559461638892e-10 3.05655023650992e-08 1.38637212777882 0.594059405940594 23.1 23 1 increased sacral vertebrae number 1.02934412894206e-06 1.78431604232987e-05 1.38565005896226 0.59375 23.1 23 1 abnormal osteoblast physiology 7.67830580560669e-06 0.000103803183105688 1.38294898672257 0.592592592592593 23.1 23 1 decreased circulating fructosamine level 0.00150024859657896 0.0102242969424388 1.38294898672257 0.592592592592593 23.1 23 1 embryonic lethality between implantation and somite formation, complete penetrance 2.1975130044705e-21 4.55526133218364e-19 1.38118502117828 0.591836734693878 23.1 23 1 increased sarcoma incidence 2.10783195565773e-05 0.000254525824742651 1.38118502117828 0.591836734693878 23.1 23 1 abnormal abdominal fat pad morphology 0.00431117574389077 0.0232878385731342 1.37902015437393 0.590909090909091 23.1 23 1 abnormal chorion morphology 0.00431117574389077 0.0232878385731342 1.37902015437393 0.590909090909091 23.1 23 1 abnormal lysosome physiology 0.00431117574389077 0.0232878385731342 1.37902015437393 0.590909090909091 23.1 23 1 decreased cardiac output 0.00431117574389077 0.0232878385731342 1.37902015437393 0.590909090909091 23.1 23 1 abnormal cerebral cortex pyramidal cell morphology 0.00431117574389077 0.0232878385731342 1.37902015437393 0.590909090909091 23.1 23 1 pulmonary vascular congestion 0.00431117574389077 0.0232878385731342 1.37902015437393 0.590909090909091 23.1 23 1 impaired humoral immune response 0.00431117574389077 0.0232878385731342 1.37902015437393 0.590909090909091 23.1 23 1 spleen hypoplasia 6.20613979782105e-10 2.30414518613132e-08 1.37800988319856 0.59047619047619 23.1 23 1 increased embryonic tissue cell apoptosis 1.03092075143903e-07 2.22027304693038e-06 1.37630019351717 0.58974358974359 23.1 23 1 impaired macrophage chemotaxis 0.00016114096576553 0.00153284188276006 1.37630019351717 0.58974358974359 23.1 23 1 abnormal embryo development 2.83639187248701e-12 1.66012347830857e-10 1.37278024417314 0.588235294117647 23.1 23 1 overexpanded pulmonary alveoli 0.000449918285418565 0.00375557028830125 1.37278024417314 0.588235294117647 23.1 23 1 abnormal endoderm development 0.000449918285418565 0.00375557028830125 1.37278024417314 0.588235294117647 23.1 23 1 abnormal spleen red pulp morphology 0.000449918285418565 0.00375557028830125 1.37278024417314 0.588235294117647 23.1 23 1 distended urinary bladder 0.0126620779712705 0.0543518877541594 1.37278024417314 0.588235294117647 23.1 23 1 abnormal vagus nerve morphology 0.0126620779712705 0.0543518877541594 1.37278024417314 0.588235294117647 23.1 23 1 abnormal dorsal-ventral axis patterning 0.0126620779712705 0.0543518877541594 1.37278024417314 0.588235294117647 23.1 23 1 decreased vasoconstriction 0.0126620779712705 0.0543518877541594 1.37278024417314 0.588235294117647 23.1 23 1 abnormal ectoplacental cone morphology 0.0126620779712705 0.0543518877541594 1.37278024417314 0.588235294117647 23.1 23 1 pancytopenia 0.0126620779712705 0.0543518877541594 1.37278024417314 0.588235294117647 23.1 23 1 coloboma 0.0126620779712705 0.0543518877541594 1.37278024417314 0.588235294117647 23.1 23 1 cardiac fibrosis 3.27333527993235e-08 8.03890406732964e-07 1.37278024417314 0.588235294117647 23.1 23 1 increased bone mineral content 4.58786653022709e-10 1.76935162696743e-08 1.3702613813398 0.587155963302752 23.1 23 1 abnormal immune system morphology 4.95603931693409e-05 0.000546702784961133 1.3697959392945 0.58695652173913 23.1 23 1 thrombocytopenia 7.82699557828619e-13 4.99221833358638e-11 1.36804651919323 0.586206896551724 23.1 23 1 abnormal parietal bone morphology 0.00126782800228733 0.00893472791600045 1.36804651919323 0.586206896551724 23.1 23 1 abnormal embryonic erythropoiesis 0.00126782800228733 0.00893472791600045 1.36804651919323 0.586206896551724 23.1 23 1 short sternum 0.00126782800228733 0.00893472791600045 1.36804651919323 0.586206896551724 23.1 23 1 increased mean corpuscular hemoglobin 3.31651024911707e-09 1.05093238785716e-07 1.367233657328 0.585858585858586 23.1 23 1 domed cranium 6.48757844012252e-07 1.190985340945e-05 1.36689690026954 0.585714285714286 23.1 23 1 embryonic lethality between somite formation and embryo turning, complete penetrance 6.48757844012252e-07 1.190985340945e-05 1.36689690026954 0.585714285714286 23.1 23 1 abnormal mammary gland development 0.000137009249837688 0.00134442015373274 1.36608375517717 0.585365853658537 23.1 23 1 increased bone trabecula number 0.000137009249837688 0.00134442015373274 1.36608375517717 0.585365853658537 23.1 23 1 abnormal brain morphology 6.9222636754776e-14 5.64561668614771e-12 1.3625483417321 0.583850931677019 23.1 23 1 abnormal axon morphology 9.06451522754778e-10 3.26782342442393e-08 1.36134040880503 0.583333333333333 23.1 23 1 curly tail 4.21742229039835e-05 0.00048000851415392 1.36134040880503 0.583333333333333 23.1 23 1 impaired wound healing 0.00038111584197257 0.00323558244678077 1.36134040880503 0.583333333333333 23.1 23 1 abnormal adipose tissue distribution 0.0385497969990246 0.127892431988595 1.36134040880503 0.583333333333333 23.1 23 1 amyloidosis 0.0385497969990246 0.127892431988595 1.36134040880503 0.583333333333333 23.1 23 1 abnormal glossopharyngeal nerve morphology 0.0385497969990246 0.127892431988595 1.36134040880503 0.583333333333333 23.1 23 1 altered tumor susceptibility 0.0385497969990246 0.127892431988595 1.36134040880503 0.583333333333333 23.1 23 1 abnormal alisphenoid bone morphology 0.0385497969990246 0.127892431988595 1.36134040880503 0.583333333333333 23.1 23 1 loss of dopaminergic neurons 0.0385497969990246 0.127892431988595 1.36134040880503 0.583333333333333 23.1 23 1 pale placenta 0.0385497969990246 0.127892431988595 1.36134040880503 0.583333333333333 23.1 23 1 small parietal bone 0.0385497969990246 0.127892431988595 1.36134040880503 0.583333333333333 23.1 23 1 abnormal patella morphology 0.0385497969990246 0.127892431988595 1.36134040880503 0.583333333333333 23.1 23 1 abnormal thymus corticomedullary boundary morphology 0.0385497969990246 0.127892431988595 1.36134040880503 0.583333333333333 23.1 23 1 reduced cerebellar foliation 0.0385497969990246 0.127892431988595 1.36134040880503 0.583333333333333 23.1 23 1 increased grip strength 2.05761471007242e-08 5.30395501689652e-07 1.3592032967033 0.582417582417582 23.1 23 1 perinatal lethality, complete penetrance 1.06284954762671e-17 1.55519897042437e-15 1.35860129329436 0.582159624413146 23.1 23 1 enlarged heart 4.10261814647164e-19 7.28947331382015e-17 1.35798735361093 0.581896551724138 23.1 23 1 abnormal embryo turning 1.30859172907373e-05 0.000168223355352501 1.35780445969125 0.581818181818182 23.1 23 1 abnormal T-helper 2 physiology 1.30859172907373e-05 0.000168223355352501 1.35780445969125 0.581818181818182 23.1 23 1 edema 1.63272937918396e-14 1.47687793844367e-12 1.35681768319438 0.581395348837209 23.1 23 1 increased oxygen consumption 5.54279410363924e-08 1.29166211564785e-06 1.35681768319438 0.581395348837209 23.1 23 1 impaired macrophage phagocytosis 0.00011624524393498 0.00115203204895722 1.35681768319438 0.581395348837209 23.1 23 1 abnormal double-strand DNA break repair 0.00011624524393498 0.00115203204895722 1.35681768319438 0.581395348837209 23.1 23 1 decreased thymus weight 0.00106865972762718 0.00787641799251141 1.35506695069994 0.580645161290323 23.1 23 1 decreased double-negative T cell number 0.00106865972762718 0.00787641799251141 1.35506695069994 0.580645161290323 23.1 23 1 small cranium 0.00106865972762718 0.00787641799251141 1.35506695069994 0.580645161290323 23.1 23 1 increased circulating alkaline phosphatase level 1.16398082329478e-13 9.3400074127283e-12 1.35413754949918 0.580246913580247 23.1 23 1 decreased double-positive T cell number 5.58993364037355e-09 1.67529637716014e-07 1.35356132075472 0.58 23.1 23 1 thymus hypoplasia 8.09287620031139e-12 4.32925366629561e-10 1.35288487831556 0.579710144927536 23.1 23 1 decreased erythrocyte cell number 3.10758635602677e-13 2.24728364515366e-11 1.35266945078716 0.579617834394904 23.1 23 1 increased blood urea nitrogen level 2.59054374407107e-12 1.53428037223257e-10 1.35195185426155 0.579310344827586 23.1 23 1 increased bone marrow cell number 0.000322150476690875 0.00277283498535831 1.35110476663356 0.578947368421053 23.1 23 1 thin dermal layer 0.010511978963476 0.0488920479996524 1.35110476663356 0.578947368421053 23.1 23 1 abnormal stationary movement 0.010511978963476 0.0488920479996524 1.35110476663356 0.578947368421053 23.1 23 1 abnormal neural crest cell migration 0.010511978963476 0.0488920479996524 1.35110476663356 0.578947368421053 23.1 23 1 abnormal digestive system development 0.010511978963476 0.0488920479996524 1.35110476663356 0.578947368421053 23.1 23 1 osteoarthritis 0.010511978963476 0.0488920479996524 1.35110476663356 0.578947368421053 23.1 23 1 Leydig cell hypoplasia 0.010511978963476 0.0488920479996524 1.35110476663356 0.578947368421053 23.1 23 1 abnormal tooth morphology 3.47544430699927e-06 5.10039393136324e-05 1.34918558372642 0.578125 23.1 23 1 abnormal CD4-positive, alpha-beta T cell physiology 1.09074037129101e-06 1.8711839128182e-05 1.34764483125166 0.577464788732394 23.1 23 1 decreased cardiac muscle contractility 4.07195168144899e-09 1.25825836119309e-07 1.34638062409289 0.576923076923077 23.1 23 1 absent corpus luteum 3.03827611573159e-05 0.000357338621176469 1.34638062409289 0.576923076923077 23.1 23 1 abnormal tooth development 0.000898947502088992 0.00668499824049736 1.34366066323613 0.575757575757576 23.1 23 1 abnormal epidermis stratum basale morphology 0.000898947502088992 0.00668499824049736 1.34366066323613 0.575757575757576 23.1 23 1 abnormal skeleton physiology 0.000898947502088992 0.00668499824049736 1.34366066323613 0.575757575757576 23.1 23 1 abnormal locomotor coordination 0.000898947502088992 0.00668499824049736 1.34366066323613 0.575757575757576 23.1 23 1 increased osteoblast cell number 0.000898947502088992 0.00668499824049736 1.34366066323613 0.575757575757576 23.1 23 1 abnormal pancreatic beta cell morphology 0.000271828034281883 0.00236423858488176 1.34189268867925 0.575 23.1 23 1 anemia 1.30772130217724e-16 1.668182943162e-14 1.33829808638111 0.57345971563981 23.1 23 1 anophthalmia 7.8557463528337e-08 1.76843158847727e-06 1.3373039007844 0.573033707865168 23.1 23 1 abnormal spleen white pulp morphology 0.000229027567540336 0.00208302038119409 1.33355795148248 0.571428571428571 23.1 23 1 abnormal hippocampus pyramidal cell morphology 0.000754957828305419 0.00569941607863347 1.33355795148248 0.571428571428571 23.1 23 1 decreased bone volume 0.000754957828305419 0.00569941607863347 1.33355795148248 0.571428571428571 23.1 23 1 abnormal circulating cholesterol level 0.00253114737492349 0.0150807882517897 1.33355795148248 0.571428571428571 23.1 23 1 abnormal jaw morphology 0.00253114737492349 0.0150807882517897 1.33355795148248 0.571428571428571 23.1 23 1 liver degeneration 0.00871268173322427 0.0419608825002815 1.33355795148248 0.571428571428571 23.1 23 1 embryonic lethality at implantation, complete penetrance 0.00871268173322427 0.0419608825002815 1.33355795148248 0.571428571428571 23.1 23 1 abnormal vasoconstriction 0.0314184408442222 0.106403501157254 1.33355795148248 0.571428571428571 23.1 23 1 extended life span 0.0314184408442222 0.106403501157254 1.33355795148248 0.571428571428571 23.1 23 1 absent visceral yolk sac blood islands 0.0314184408442222 0.106403501157254 1.33355795148248 0.571428571428571 23.1 23 1 abnormal spleen periarteriolar lymphoid sheath morphology 0.0314184408442222 0.106403501157254 1.33355795148248 0.571428571428571 23.1 23 1 increased hemangioma incidence 0.0314184408442222 0.106403501157254 1.33355795148248 0.571428571428571 23.1 23 1 absent otoliths 0.0314184408442222 0.106403501157254 1.33355795148248 0.571428571428571 23.1 23 1 intestinal obstruction 0.0314184408442222 0.106403501157254 1.33355795148248 0.571428571428571 23.1 23 1 abnormal maternal decidual layer morphology 0.0314184408442222 0.106403501157254 1.33355795148248 0.571428571428571 23.1 23 1 decreased CNS synapse formation 0.0314184408442222 0.106403501157254 1.33355795148248 0.571428571428571 23.1 23 1 decreased cornea thickness 0.0314184408442222 0.106403501157254 1.33355795148248 0.571428571428571 23.1 23 1 abnormal respiratory system physiology 7.03020940338589e-05 0.000748935584193679 1.33355795148248 0.571428571428571 23.1 23 1 abnormal craniofacial development 7.03020940338589e-05 0.000748935584193679 1.33355795148248 0.571428571428571 23.1 23 1 abnormal bone mineralization 5.79802108629887e-10 2.18523900790431e-08 1.33080266645876 0.570247933884298 23.1 23 1 decreased leukocyte cell number 5.02348634150109e-11 2.45018083813411e-09 1.32869095165955 0.569343065693431 23.1 23 1 abnormal dendritic spine morphology 5.92990650135378e-05 0.000648379886686484 1.3270209027007 0.568627450980392 23.1 23 1 abnormal myelopoiesis 0.000192725843086791 0.00180567056376042 1.32598091766724 0.568181818181818 23.1 23 1 small seminiferous tubules 1.52336040642774e-06 2.50950927880066e-05 1.32454742478327 0.567567567567568 23.1 23 1 skin inflammation 0.000633201041149027 0.00498445439828546 1.32454742478327 0.567567567567568 23.1 23 1 abnormal myocardial fiber morphology 4.07396606654834e-08 9.74422172167212e-07 1.3232469363937 0.56701030927835 23.1 23 1 kyphosis 9.84487653823576e-12 5.21045327422584e-10 1.32244496855346 0.566666666666667 23.1 23 1 delayed eyelid opening 0.0021125734717882 0.0130884844609543 1.32244496855346 0.566666666666667 23.1 23 1 increased insulin sensitivity 3.07722233854225e-11 1.55728951903547e-09 1.32190097638211 0.566433566433566 23.1 23 1 abnormal circulating insulin level 0.00721428456125518 0.0364746602563461 1.31906275635767 0.565217391304348 23.1 23 1 abnormal nasal cavity morphology 0.00721428456125518 0.0364746602563461 1.31906275635767 0.565217391304348 23.1 23 1 abnormal B cell morphology 0.00721428456125518 0.0364746602563461 1.31906275635767 0.565217391304348 23.1 23 1 abnormal bone structure 1.72534713566915e-14 1.53278607142036e-12 1.31801129142634 0.564766839378238 23.1 23 1 decreased neutrophil cell number 2.50729854819835e-09 8.37007370396821e-08 1.3164610546686 0.564102564102564 23.1 23 1 abnormal heart looping 0.000530515726123676 0.00433385178565728 1.3164610546686 0.564102564102564 23.1 23 1 abnormal joint morphology 4.20667659709567e-05 0.000480004955746582 1.3153730703259 0.563636363636364 23.1 23 1 atelectasis 3.45945759868186e-06 5.09195312232019e-05 1.31477544512357 0.563380281690141 23.1 23 1 embryonic growth arrest 9.46031050720114e-17 1.3073623548146e-14 1.31463191068633 0.563318777292576 23.1 23 1 abnormal cardiovascular system morphology 0.000136061281963561 0.00134040569855191 1.31272110849057 0.5625 23.1 23 1 abnormal osteoclast morphology 0.000136061281963561 0.00134040569855191 1.31272110849057 0.5625 23.1 23 1 abnormal depression-related behavior 0.00176150972938668 0.0110790276911488 1.31272110849057 0.5625 23.1 23 1 bradykinesia 0.00176150972938668 0.0110790276911488 1.31272110849057 0.5625 23.1 23 1 pancreatic islet hyperplasia 0.00176150972938668 0.0110790276911488 1.31272110849057 0.5625 23.1 23 1 poor circulation 0.0256251729087834 0.0981410586768265 1.31272110849057 0.5625 23.1 23 1 abnormal olfaction 0.0256251729087834 0.0981410586768265 1.31272110849057 0.5625 23.1 23 1 large intestinal inflammation 0.0256251729087834 0.0981410586768265 1.31272110849057 0.5625 23.1 23 1 increased cochlear outer hair cell number 0.0256251729087834 0.0981410586768265 1.31272110849057 0.5625 23.1 23 1 small epididymis 0.0256251729087834 0.0981410586768265 1.31272110849057 0.5625 23.1 23 1 kidney degeneration 0.0256251729087834 0.0981410586768265 1.31272110849057 0.5625 23.1 23 1 impaired somite development 0.0256251729087834 0.0981410586768265 1.31272110849057 0.5625 23.1 23 1 increased heart left ventricle size 0.0256251729087834 0.0981410586768265 1.31272110849057 0.5625 23.1 23 1 premature death 6.57637451446144e-59 8.17936580236141e-56 1.31187408235268 0.562137049941928 23.1 23 1 decreased rib number 2.45461490457523e-07 4.90430086355894e-06 1.31108225567098 0.561797752808989 23.1 23 1 abnormal B cell differentiation 2.07263329455882e-07 4.20871454711434e-06 1.30791260626166 0.56043956043956 23.1 23 1 decreased heart rate 5.55609432660585e-08 1.29166211564785e-06 1.30688679245283 0.56 23.1 23 1 abnormal axon extension 0.000114182818511052 0.00113611904418497 1.30688679245283 0.56 23.1 23 1 decreased respiratory quotient 0.000114182818511052 0.00113611904418497 1.30688679245283 0.56 23.1 23 1 abnormal primitive streak morphology 0.00597023884379487 0.0313311584893243 1.30688679245283 0.56 23.1 23 1 abnormal vertebrae development 0.00597023884379487 0.0313311584893243 1.30688679245283 0.56 23.1 23 1 abnormal vertebrae morphology 1.49367627636507e-08 3.99518251339581e-07 1.30603037908949 0.559633027522936 23.1 23 1 thin skin 0.00146771784320486 0.0100163186144639 1.30414123196448 0.558823529411765 23.1 23 1 abnormal brown adipose tissue morphology 0.00146771784320486 0.0100163186144639 1.30414123196448 0.558823529411765 23.1 23 1 decreased body length 4.25174889034102e-19 7.29394852739538e-17 1.30313920258918 0.558394160583942 23.1 23 1 increased circulating creatinine level 5.51798540125712e-07 1.02816394648892e-05 1.30254497586661 0.558139534883721 23.1 23 1 increased susceptibility to injury 9.57587524844252e-05 0.00098293947072217 1.30150126995646 0.557692307692308 23.1 23 1 abnormal nervous system morphology 1.74489747979322e-06 2.82764331008836e-05 1.29979699068545 0.556962025316456 23.1 23 1 extramedullary hematopoiesis 3.33947590496299e-08 8.14406501332886e-07 1.29896092915628 0.556603773584906 23.1 23 1 abnormal neuromuscular synapse morphology 5.53382569316495e-06 7.77705729477278e-05 1.29651467505241 0.555555555555556 23.1 23 1 abnormal uterus morphology 0.00122226031122148 0.00882546451135973 1.29651467505241 0.555555555555556 23.1 23 1 abnormal limb bone morphology 0.00122226031122148 0.00882546451135973 1.29651467505241 0.555555555555556 23.1 23 1 eye inflammation 0.0209219076742257 0.0840763252659715 1.29651467505241 0.555555555555556 23.1 23 1 abnormal thymus medulla morphology 0.0209219076742257 0.0840763252659715 1.29651467505241 0.555555555555556 23.1 23 1 increased circulating renin level 0.0209219076742257 0.0840763252659715 1.29651467505241 0.555555555555556 23.1 23 1 absent inner cell mass 0.0209219076742257 0.0840763252659715 1.29651467505241 0.555555555555556 23.1 23 1 jerky movement 0.0209219076742257 0.0840763252659715 1.29651467505241 0.555555555555556 23.1 23 1 increased gastrointestinal tumor incidence 0.0209219076742257 0.0840763252659715 1.29651467505241 0.555555555555556 23.1 23 1 abnormal head movements 0.0987364311360198 0.236274047571765 1.29651467505241 0.555555555555556 23.1 23 1 thick tail 0.0987364311360198 0.236274047571765 1.29651467505241 0.555555555555556 23.1 23 1 absent parathyroid glands 0.0987364311360198 0.236274047571765 1.29651467505241 0.555555555555556 23.1 23 1 abnormal sympathetic neuron morphology 0.0987364311360198 0.236274047571765 1.29651467505241 0.555555555555556 23.1 23 1 small nodose ganglion 0.0987364311360198 0.236274047571765 1.29651467505241 0.555555555555556 23.1 23 1 abnormal vagina epithelium morphology 0.0987364311360198 0.236274047571765 1.29651467505241 0.555555555555556 23.1 23 1 decreased level of surface class I molecules 0.0987364311360198 0.236274047571765 1.29651467505241 0.555555555555556 23.1 23 1 increased pheochromocytoma incidence 0.0987364311360198 0.236274047571765 1.29651467505241 0.555555555555556 23.1 23 1 abnormal thymus lobule morphology 0.0987364311360198 0.236274047571765 1.29651467505241 0.555555555555556 23.1 23 1 abnormal abdominal wall morphology 0.0987364311360198 0.236274047571765 1.29651467505241 0.555555555555556 23.1 23 1 biliary cyst 0.0987364311360198 0.236274047571765 1.29651467505241 0.555555555555556 23.1 23 1 impaired febrile response 0.0987364311360198 0.236274047571765 1.29651467505241 0.555555555555556 23.1 23 1 abnormal proprioceptive neuron morphology 0.0987364311360198 0.236274047571765 1.29651467505241 0.555555555555556 23.1 23 1 abnormal gallbladder physiology 0.0987364311360198 0.236274047571765 1.29651467505241 0.555555555555556 23.1 23 1 abnormal posterior eye segment morphology 0.0987364311360198 0.236274047571765 1.29651467505241 0.555555555555556 23.1 23 1 hemothorax 0.0987364311360198 0.236274047571765 1.29651467505241 0.555555555555556 23.1 23 1 abnormal leukopoiesis 0.0987364311360198 0.236274047571765 1.29651467505241 0.555555555555556 23.1 23 1 abnormal optic chiasm morphology 0.0987364311360198 0.236274047571765 1.29651467505241 0.555555555555556 23.1 23 1 eye opacity 0.0987364311360198 0.236274047571765 1.29651467505241 0.555555555555556 23.1 23 1 decreased transitional stage T1 B cell number 0.0987364311360198 0.236274047571765 1.29651467505241 0.555555555555556 23.1 23 1 abnormal cerebellar layer morphology 0.0987364311360198 0.236274047571765 1.29651467505241 0.555555555555556 23.1 23 1 axonal spheroids 0.0987364311360198 0.236274047571765 1.29651467505241 0.555555555555556 23.1 23 1 abnormal incisor color 0.0987364311360198 0.236274047571765 1.29651467505241 0.555555555555556 23.1 23 1 abnormal ventricle myocardium morphology 0.0987364311360198 0.236274047571765 1.29651467505241 0.555555555555556 23.1 23 1 shortened ST segment 0.0987364311360198 0.236274047571765 1.29651467505241 0.555555555555556 23.1 23 1 fusion of atlas and occipital bones 0.0987364311360198 0.236274047571765 1.29651467505241 0.555555555555556 23.1 23 1 abnormal oxidative phosphorylation 0.0987364311360198 0.236274047571765 1.29651467505241 0.555555555555556 23.1 23 1 abnormal lung lobe morphology 0.0987364311360198 0.236274047571765 1.29651467505241 0.555555555555556 23.1 23 1 reduced AMPA-mediated synaptic currents 0.0987364311360198 0.236274047571765 1.29651467505241 0.555555555555556 23.1 23 1 increased core body temperature 0.0987364311360198 0.236274047571765 1.29651467505241 0.555555555555556 23.1 23 1 trigeminal neuroma 0.0987364311360198 0.236274047571765 1.29651467505241 0.555555555555556 23.1 23 1 abnormal coronary sinus connection 0.0987364311360198 0.236274047571765 1.29651467505241 0.555555555555556 23.1 23 1 increased cardiac muscle glycogen level 0.0987364311360198 0.236274047571765 1.29651467505241 0.555555555555556 23.1 23 1 increased endoplasmic reticulum stress 0.0987364311360198 0.236274047571765 1.29651467505241 0.555555555555556 23.1 23 1 increased exploration in new environment 1.46857045056585e-06 2.4353793305217e-05 1.29651467505241 0.555555555555556 23.1 23 1 abnormal autopod morphology 0.000310570527325318 0.00267779614114984 1.29651467505241 0.555555555555556 23.1 23 1 abnormal trigeminal nerve morphology 0.00493931718131909 0.0264511334521663 1.29651467505241 0.555555555555556 23.1 23 1 abnormal trigeminal ganglion morphology 0.00493931718131909 0.0264511334521663 1.29651467505241 0.555555555555556 23.1 23 1 thin epidermis 0.00493931718131909 0.0264511334521663 1.29651467505241 0.555555555555556 23.1 23 1 abnormal palate morphology 0.00493931718131909 0.0264511334521663 1.29651467505241 0.555555555555556 23.1 23 1 postnatal lethality, incomplete penetrance 4.61806896954778e-37 2.29748931235002e-34 1.29423207879352 0.554577464788732 23.1 23 1 increased heart weight 3.93353459008359e-10 1.5408924870603e-08 1.29278369757025 0.553956834532374 23.1 23 1 postnatal growth retardation 1.17052423688179e-39 7.27919759810866e-37 1.29270139659637 0.553921568627451 23.1 23 1 abnormal tibia morphology 0.000259515249037202 0.00231377843003599 1.29099759132878 0.553191489361702 23.1 23 1 persistence of hyaloid vascular system 0.00101743997371498 0.00753238671016671 1.28969091360477 0.552631578947368 23.1 23 1 internal hemorrhage 1.47755211936526e-05 0.000187078087470995 1.28877428893269 0.552238805970149 23.1 23 1 cyanosis 2.92247868175587e-13 2.17004946891574e-11 1.28841145833333 0.552083333333333 23.1 23 1 abnormal CD8-positive, alpha-beta T cell physiology 0.00408600198739874 0.0229175421502917 1.28757319453481 0.551724137931034 23.1 23 1 infertility 5.27132616109257e-08 1.23702111563375e-06 1.28682110738847 0.551401869158878 23.1 23 1 abnormal dendritic cell physiology 5.27132616109257e-08 1.23702111563375e-06 1.28682110738847 0.551401869158878 23.1 23 1 increased urine protein level 3.28063443891753e-06 4.84307309602811e-05 1.28654148524432 0.551282051282051 23.1 23 1 abnormal retinal pigment epithelium morphology 2.75388303972964e-06 4.28142753832967e-05 1.28354952830189 0.55 23.1 23 1 abnormal fibula morphology 0.017101368827954 0.0706638786703249 1.28354952830189 0.55 23.1 23 1 absent placental labyrinth 0.017101368827954 0.0706638786703249 1.28354952830189 0.55 23.1 23 1 abnormal response to tactile stimuli 0.017101368827954 0.0706638786703249 1.28354952830189 0.55 23.1 23 1 liver inflammation 1.00510630160627e-08 2.88960186024589e-07 1.28354952830189 0.55 23.1 23 1 abnormal incisor morphology 4.71310661909397e-05 0.0005210601206665 1.28354952830189 0.55 23.1 23 1 abnormal hepatocyte morphology 3.73038169188471e-08 9.00905287239147e-07 1.28249830018698 0.54954954954955 23.1 23 1 decreased liver weight 1.03869098135911e-05 0.000136880102721479 1.28190605899548 0.549295774647887 23.1 23 1 kinked tail 1.38775292354085e-07 2.95045760453664e-06 1.28126156122826 0.549019607843137 23.1 23 1 increased lung adenocarcinoma incidence 0.000180997822768897 0.00170866066086388 1.28126156122826 0.549019607843137 23.1 23 1 decreased body size 1.47444868761379e-49 1.46707644417572e-46 1.28091750602922 0.548872180451128 23.1 23 1 impaired glucose tolerance 2.88783332524238e-16 3.16774218124616e-14 1.27978545343883 0.548387096774194 23.1 23 1 abnormal eyelid morphology 0.00338018301826945 0.0196913472083027 1.27978545343883 0.548387096774194 23.1 23 1 abnormal object recognition memory 0.00338018301826945 0.0196913472083027 1.27978545343883 0.548387096774194 23.1 23 1 abnormal mitochondrial ATP synthesis coupled electron transport 0.00338018301826945 0.0196913472083027 1.27978545343883 0.548387096774194 23.1 23 1 hypoglycemia 5.17760903746536e-07 9.79414637315215e-06 1.27978545343883 0.548387096774194 23.1 23 1 decreased hematocrit 3.68408902926156e-10 1.45463039052192e-08 1.27875420005169 0.547945205479452 23.1 23 1 skin edema 0.000704443060609635 0.00546740128944296 1.27799303683738 0.547619047619048 23.1 23 1 abnormal reproductive system morphology 0.000704443060609635 0.00546740128944296 1.27799303683738 0.547619047619048 23.1 23 1 preweaning lethality, complete penetrance 1.8282373899715e-45 1.29935443072974e-42 1.27724215961244 0.547297297297297 23.1 23 1 neonatal lethality, incomplete penetrance 1.02787517004088e-16 1.38207539755496e-14 1.2745736574746 0.546153846153846 23.1 23 1 abnormal astrocyte morphology 0.000586005778272106 0.00468710409470053 1.27294168096055 0.545454545454545 23.1 23 1 decreased macrophage cell number 0.000586005778272106 0.00468710409470053 1.27294168096055 0.545454545454545 23.1 23 1 abnormal long bone epiphysis morphology 0.0139944889204245 0.0591525763628818 1.27294168096055 0.545454545454545 23.1 23 1 abnormal facial nerve morphology 0.0139944889204245 0.0591525763628818 1.27294168096055 0.545454545454545 23.1 23 1 increased body size 0.0139944889204245 0.0591525763628818 1.27294168096055 0.545454545454545 23.1 23 1 increased coping response 0.0139944889204245 0.0591525763628818 1.27294168096055 0.545454545454545 23.1 23 1 decreased circulating estradiol level 0.0139944889204245 0.0591525763628818 1.27294168096055 0.545454545454545 23.1 23 1 failure of palatal shelf elevation 0.0139944889204245 0.0591525763628818 1.27294168096055 0.545454545454545 23.1 23 1 rough coat 0.0139944889204245 0.0591525763628818 1.27294168096055 0.545454545454545 23.1 23 1 increased mammary gland tumor incidence 0.0139944889204245 0.0591525763628818 1.27294168096055 0.545454545454545 23.1 23 1 increased bone volume 0.0139944889204245 0.0591525763628818 1.27294168096055 0.545454545454545 23.1 23 1 embryonic lethality before implantation, incomplete penetrance 0.0139944889204245 0.0591525763628818 1.27294168096055 0.545454545454545 23.1 23 1 abnormal ear position 0.0781513806294092 0.219786952307129 1.27294168096055 0.545454545454545 23.1 23 1 absent semicircular canals 0.0781513806294092 0.219786952307129 1.27294168096055 0.545454545454545 23.1 23 1 increased mast cell number 0.0781513806294092 0.219786952307129 1.27294168096055 0.545454545454545 23.1 23 1 enlarged cranium 0.0781513806294092 0.219786952307129 1.27294168096055 0.545454545454545 23.1 23 1 delayed hepatic development 0.0781513806294092 0.219786952307129 1.27294168096055 0.545454545454545 23.1 23 1 social withdrawal 0.0781513806294092 0.219786952307129 1.27294168096055 0.545454545454545 23.1 23 1 abnormal hemoglobin 0.0781513806294092 0.219786952307129 1.27294168096055 0.545454545454545 23.1 23 1 focal hepatic necrosis 0.0781513806294092 0.219786952307129 1.27294168096055 0.545454545454545 23.1 23 1 fatigue 0.0781513806294092 0.219786952307129 1.27294168096055 0.545454545454545 23.1 23 1 fused joints 0.0781513806294092 0.219786952307129 1.27294168096055 0.545454545454545 23.1 23 1 abnormal frequency of paradoxical sleep 0.0781513806294092 0.219786952307129 1.27294168096055 0.545454545454545 23.1 23 1 impaired luteinization 0.0781513806294092 0.219786952307129 1.27294168096055 0.545454545454545 23.1 23 1 pulmonary hypertension 0.0781513806294092 0.219786952307129 1.27294168096055 0.545454545454545 23.1 23 1 abnormal lymph circulation 0.0781513806294092 0.219786952307129 1.27294168096055 0.545454545454545 23.1 23 1 cyclopia 0.0781513806294092 0.219786952307129 1.27294168096055 0.545454545454545 23.1 23 1 shortened PR interval 0.0781513806294092 0.219786952307129 1.27294168096055 0.545454545454545 23.1 23 1 aorta dilation 0.0781513806294092 0.219786952307129 1.27294168096055 0.545454545454545 23.1 23 1 abnormal extraembryonic ectoderm morphology 0.0781513806294092 0.219786952307129 1.27294168096055 0.545454545454545 23.1 23 1 abnormal phrenic nerve innervation pattern to diaphragm 0.0781513806294092 0.219786952307129 1.27294168096055 0.545454545454545 23.1 23 1 hypolactation 0.0781513806294092 0.219786952307129 1.27294168096055 0.545454545454545 23.1 23 1 thin hypoglossal nerve 0.0781513806294092 0.219786952307129 1.27294168096055 0.545454545454545 23.1 23 1 decreased body weight 8.17340986018695e-75 4.06627140544301e-71 1.27242756881153 0.545234248788368 23.1 23 1 abnormal placenta labyrinth morphology 5.11498691787155e-06 7.29142117948738e-05 1.27025614998806 0.544303797468354 23.1 23 1 decreased circulating alanine transaminase level 2.30725069223113e-05 0.000276592101056624 1.26982172586016 0.544117647058823 23.1 23 1 embryonic lethality before implantation, complete penetrance 1.10350078561161e-08 3.10164768837163e-07 1.26954716981132 0.544 23.1 23 1 abnormal cell death 0.000487432215830951 0.00404837274417193 1.26832957342084 0.543478260869565 23.1 23 1 increased neuron apoptosis 4.28236287549201e-06 6.2112989229075e-05 1.26770323782902 0.54320987654321 23.1 23 1 increased red blood cell distribution width 0.00231412036089794 0.0142661075532432 1.26688005390836 0.542857142857143 23.1 23 1 abnormal heart left ventricle morphology 1.6122372865004e-05 0.000200522012508487 1.2641018081761 0.541666666666667 23.1 23 1 abnormal digestive system morphology 0.0114646872939493 0.0498138159715266 1.2641018081761 0.541666666666667 23.1 23 1 abnormal foregut morphology 0.0114646872939493 0.0498138159715266 1.2641018081761 0.541666666666667 23.1 23 1 abnormal adrenal gland morphology 0.0114646872939493 0.0498138159715266 1.2641018081761 0.541666666666667 23.1 23 1 abnormal body weight 0.0114646872939493 0.0498138159715266 1.2641018081761 0.541666666666667 23.1 23 1 abnormal nursing 0.0114646872939493 0.0498138159715266 1.2641018081761 0.541666666666667 23.1 23 1 increased stereotypic behavior 0.0114646872939493 0.0498138159715266 1.2641018081761 0.541666666666667 23.1 23 1 abnormal startle reflex 0.0114646872939493 0.0498138159715266 1.2641018081761 0.541666666666667 23.1 23 1 abnormal cardiac muscle contractility 0.0114646872939493 0.0498138159715266 1.2641018081761 0.541666666666667 23.1 23 1 abnormal impulse conducting system conduction 0.0114646872939493 0.0498138159715266 1.2641018081761 0.541666666666667 23.1 23 1 abnormal inner cell mass apoptosis 0.0114646872939493 0.0498138159715266 1.2641018081761 0.541666666666667 23.1 23 1 decreased bone mineral density 1.72740933475549e-16 1.99857242800199e-14 1.26337069087814 0.541353383458647 23.1 23 1 decreased T cell proliferation 8.78472592149504e-10 3.19007382915604e-08 1.26147373788883 0.540540540540541 23.1 23 1 increased granulocyte number 1.34738985140717e-05 0.000172764549246151 1.26147373788883 0.540540540540541 23.1 23 1 increased circulating phosphate level 0.00191527121718906 0.0119404439918741 1.26147373788883 0.540540540540541 23.1 23 1 abnormal breathing pattern 0.00191527121718906 0.0119404439918741 1.26147373788883 0.540540540540541 23.1 23 1 impaired skeletal muscle contractility 0.00191527121718906 0.0119404439918741 1.26147373788883 0.540540540540541 23.1 23 1 decreased circulating chloride level 0.00191527121718906 0.0119404439918741 1.26147373788883 0.540540540540541 23.1 23 1 abnormal respiratory electron transport chain 0.00191527121718906 0.0119404439918741 1.26147373788883 0.540540540540541 23.1 23 1 abnormal hindlimb morphology 0.000337189169307212 0.00289226916776445 1.26021226415094 0.54 23.1 23 1 kidney inflammation 0.000337189169307212 0.00289226916776445 1.26021226415094 0.54 23.1 23 1 skin lesions 6.10739152923836e-05 0.000664863738686233 1.25947139862234 0.53968253968254 23.1 23 1 decreased susceptibility to hepatic steatosis 6.10739152923836e-05 0.000664863738686233 1.25947139862234 0.53968253968254 23.1 23 1 abnormal testis morphology 7.47815176056163e-08 1.70065577862503e-06 1.25818293683347 0.539130434782609 23.1 23 1 decreased hemoglobin content 2.71267892143831e-09 8.76336210010102e-08 1.25789508898702 0.539007092198582 23.1 23 1 decreased grip strength 1.35744504221686e-13 1.04931083174164e-11 1.25744163005083 0.538812785388128 23.1 23 1 reduced female fertility 2.61268108658589e-14 2.28036638697628e-12 1.2573956977879 0.538793103448276 23.1 23 1 decreased bone mineral content 5.92120361659283e-13 3.82571272630511e-11 1.25662191582003 0.538461538461538 23.1 23 1 abnormal female meiosis 0.000280443404767446 0.00243491437821648 1.25662191582003 0.538461538461538 23.1 23 1 decreased bone resorption 0.00940200671790374 0.0449157909178853 1.25662191582003 0.538461538461538 23.1 23 1 abnormal nerve conduction 0.00940200671790374 0.0449157909178853 1.25662191582003 0.538461538461538 23.1 23 1 tight skin 0.062302339197716 0.185379268844879 1.25662191582003 0.538461538461538 23.1 23 1 dystrophic cardiac calcinosis 0.062302339197716 0.185379268844879 1.25662191582003 0.538461538461538 23.1 23 1 abnormal bile duct development 0.062302339197716 0.185379268844879 1.25662191582003 0.538461538461538 23.1 23 1 abnormal coping response 0.062302339197716 0.185379268844879 1.25662191582003 0.538461538461538 23.1 23 1 absent lateral semicircular canal 0.062302339197716 0.185379268844879 1.25662191582003 0.538461538461538 23.1 23 1 tracheoesophageal fistula 0.062302339197716 0.185379268844879 1.25662191582003 0.538461538461538 23.1 23 1 abnormal vestibulocochlear ganglion morphology 0.062302339197716 0.185379268844879 1.25662191582003 0.538461538461538 23.1 23 1 increased cochlear inner hair cell number 0.062302339197716 0.185379268844879 1.25662191582003 0.538461538461538 23.1 23 1 empty decidua capsularis 0.062302339197716 0.185379268844879 1.25662191582003 0.538461538461538 23.1 23 1 increased prostaglandin level 0.062302339197716 0.185379268844879 1.25662191582003 0.538461538461538 23.1 23 1 decreased cardiac stroke volume 0.062302339197716 0.185379268844879 1.25662191582003 0.538461538461538 23.1 23 1 insulin resistance 9.99016517727648e-09 2.88959719517154e-07 1.25526193539165 0.537878787878788 23.1 23 1 abnormal femur morphology 4.24787801497862e-05 0.00048000851415392 1.25394255139397 0.537313432835821 23.1 23 1 impaired limb coordination 0.000233251083090079 0.00211370517007858 1.25329751921733 0.537037037037037 23.1 23 1 decreased total body fat amount 1.60798369892478e-19 3.07681496236568e-17 1.25070966557451 0.535928143712575 23.1 23 1 hypoactivity 7.97575481181246e-22 1.8036081903985e-19 1.25043166007707 0.535809018567639 23.1 23 1 hypoxia 0.00771797465023711 0.0389026584447109 1.25021057951482 0.535714285714286 23.1 23 1 prolonged QRS complex duration 0.00771797465023711 0.0389026584447109 1.25021057951482 0.535714285714286 23.1 23 1 abnormal neuron morphology 8.59608422273281e-07 1.54947532638028e-05 1.24936868686869 0.535353535353535 23.1 23 1 increased circulating free fatty acid level 2.95388757515945e-05 0.000349063911791408 1.24903667286739 0.535211267605634 23.1 23 1 seminiferous tubule degeneration 2.46310268423748e-05 0.000293859372999556 1.2467853450504 0.534246575342466 23.1 23 1 oxidative stress 3.19454186872671e-06 4.74413307370609e-05 1.24465408805031 0.533333333333333 23.1 23 1 small placenta 0.00090078892221129 0.00668632597743629 1.24465408805031 0.533333333333333 23.1 23 1 enhanced paired-pulse facilitation 0.00634134886238225 0.0327603432921617 1.24465408805031 0.533333333333333 23.1 23 1 decreased hepatocyte number 0.0499414937700068 0.156855386051631 1.24465408805031 0.533333333333333 23.1 23 1 decreased salivation 0.0499414937700068 0.156855386051631 1.24465408805031 0.533333333333333 23.1 23 1 abnormal apical ectodermal ridge morphology 0.0499414937700068 0.156855386051631 1.24465408805031 0.533333333333333 23.1 23 1 absent egg cylinders 0.0499414937700068 0.156855386051631 1.24465408805031 0.533333333333333 23.1 23 1 placental labyrinth hypoplasia 0.0499414937700068 0.156855386051631 1.24465408805031 0.533333333333333 23.1 23 1 joint inflammation 0.0499414937700068 0.156855386051631 1.24465408805031 0.533333333333333 23.1 23 1 arthritis 0.0499414937700068 0.156855386051631 1.24465408805031 0.533333333333333 23.1 23 1 abnormal zygomatic bone morphology 0.0499414937700068 0.156855386051631 1.24465408805031 0.533333333333333 23.1 23 1 immune system phenotype 0.0499414937700068 0.156855386051631 1.24465408805031 0.533333333333333 23.1 23 1 abnormal energy homeostasis 0.0499414937700068 0.156855386051631 1.24465408805031 0.533333333333333 23.1 23 1 abnormal cerebral aqueduct morphology 0.0499414937700068 0.156855386051631 1.24465408805031 0.533333333333333 23.1 23 1 decreased thymocyte apoptosis 0.0499414937700068 0.156855386051631 1.24465408805031 0.533333333333333 23.1 23 1 absent chorion 0.0499414937700068 0.156855386051631 1.24465408805031 0.533333333333333 23.1 23 1 decreased brown adipose tissue mass 0.0499414937700068 0.156855386051631 1.24465408805031 0.533333333333333 23.1 23 1 abnormal locomotor behavior 2.66772601959269e-06 4.17356507782189e-05 1.24296298195242 0.532608695652174 23.1 23 1 abnormal T-helper 1 physiology 0.000746428769005666 0.00566079744787072 1.24134383781614 0.531914893617021 23.1 23 1 decreased circulating HDL cholesterol level 3.89835454083292e-08 9.36923373944143e-07 1.23979215801887 0.53125 23.1 23 1 decreased circulating LDL cholesterol level 9.28990226166628e-05 0.000958864393190658 1.23979215801887 0.53125 23.1 23 1 decreased caudal vertebrae number 9.28990226166628e-05 0.000958864393190658 1.23979215801887 0.53125 23.1 23 1 decreased startle reflex 1.71318411021298e-07 3.551287895129e-06 1.23667553620384 0.52991452991453 23.1 23 1 decreased mean corpuscular hemoglobin 6.43108375306956e-05 0.000698572962260285 1.23550221975583 0.529411764705882 23.1 23 1 impaired synaptic plasticity 0.00429155928095035 0.0232878385731342 1.23550221975583 0.529411764705882 23.1 23 1 increased susceptibility to viral infection induced morbidity/mortality 0.00429155928095035 0.0232878385731342 1.23550221975583 0.529411764705882 23.1 23 1 abnormal glutamate-mediated receptor currents 0.0402086547134855 0.131951225065693 1.23550221975583 0.529411764705882 23.1 23 1 abnormal tarsal bone morphology 0.0402086547134855 0.131951225065693 1.23550221975583 0.529411764705882 23.1 23 1 increased brain size 0.0402086547134855 0.131951225065693 1.23550221975583 0.529411764705882 23.1 23 1 abnormal tendon morphology 0.0402086547134855 0.131951225065693 1.23550221975583 0.529411764705882 23.1 23 1 enhanced behavioral response to cocaine 0.0402086547134855 0.131951225065693 1.23550221975583 0.529411764705882 23.1 23 1 increased hepatoma incidence 0.0402086547134855 0.131951225065693 1.23550221975583 0.529411764705882 23.1 23 1 abnormal ductus venosus valve morphology 0.0402086547134855 0.131951225065693 1.23550221975583 0.529411764705882 23.1 23 1 decreased body fat mass 0.0402086547134855 0.131951225065693 1.23550221975583 0.529411764705882 23.1 23 1 abnormal cell cytoskeleton morphology 0.0402086547134855 0.131951225065693 1.23550221975583 0.529411764705882 23.1 23 1 impaired balance 1.08285250102282e-06 1.86407999743549e-05 1.23550221975583 0.529411764705882 23.1 23 1 abnormal cued conditioning behavior 0.000512904434162818 0.00419687427625003 1.23550221975583 0.529411764705882 23.1 23 1 abnormal gastrulation 0.000512904434162818 0.00419687427625003 1.23550221975583 0.529411764705882 23.1 23 1 azoospermia 1.49451938436691e-09 5.12774754291405e-08 1.23291206835173 0.528301886792453 23.1 23 1 abnormal pancreatic islet morphology 0.000425319223545609 0.00358030987671642 1.23291206835173 0.528301886792453 23.1 23 1 limb grasping 1.1772201584015e-10 5.27627953878149e-09 1.23097657059921 0.527472527472527 23.1 23 1 abnormal glucose homeostasis 1.1772201584015e-10 5.27627953878149e-09 1.23097657059921 0.527472527472527 23.1 23 1 lethargy 4.00187655880956e-06 5.83851492084386e-05 1.22959778859809 0.526881720430108 23.1 23 1 decreased brain weight 0.000292663044913804 0.00253658301123027 1.22827706057597 0.526315789473684 23.1 23 1 decreased total retina thickness 0.0029128614877158 0.0171496874572617 1.22827706057597 0.526315789473684 23.1 23 1 decreased tumor incidence 0.0324884951306142 0.109431457870552 1.22827706057597 0.526315789473684 23.1 23 1 abnormal metatarsal bone morphology 0.0324884951306142 0.109431457870552 1.22827706057597 0.526315789473684 23.1 23 1 oliguria 0.0324884951306142 0.109431457870552 1.22827706057597 0.526315789473684 23.1 23 1 abnormal blastocyst morphology 0.0324884951306142 0.109431457870552 1.22827706057597 0.526315789473684 23.1 23 1 increased circulating VLDL cholesterol level 0.0324884951306142 0.109431457870552 1.22827706057597 0.526315789473684 23.1 23 1 increased liver cholesterol level 0.0324884951306142 0.109431457870552 1.22827706057597 0.526315789473684 23.1 23 1 decreased susceptibility to weight gain 0.0324884951306142 0.109431457870552 1.22827706057597 0.526315789473684 23.1 23 1 right-sided stomach 0.0324884951306142 0.109431457870552 1.22827706057597 0.526315789473684 23.1 23 1 respiratory distress 4.27764519747901e-10 1.66260037948891e-08 1.22756707383575 0.526011560693642 23.1 23 1 syndactyly 0.000242848984232349 0.00218872046477525 1.22619523504957 0.525423728813559 23.1 23 1 abnormal thoracic vertebrae morphology 0.000242848984232349 0.00218872046477525 1.22619523504957 0.525423728813559 23.1 23 1 perinatal lethality 0.00240211839457846 0.0145117957475953 1.22520636792453 0.525 23.1 23 1 increased circulating triglyceride level 1.38498022216349e-08 3.78586626662822e-07 1.22319453480807 0.524137931034483 23.1 23 1 gliosis 0.00016731762613803 0.001585533695308 1.22242812219227 0.523809523809524 23.1 23 1 abnormal humoral immune response 1.34600143770596e-06 2.23958433196895e-05 1.22242812219227 0.523809523809524 23.1 23 1 decreased exploration in new environment 1.48158324549894e-05 0.000187078087470995 1.22242812219227 0.523809523809524 23.1 23 1 small ears 0.0263289246321567 0.0982794864647516 1.22242812219227 0.523809523809524 23.1 23 1 increased vasoconstriction 0.0263289246321567 0.0982794864647516 1.22242812219227 0.523809523809524 23.1 23 1 abnormal embryonic/fetal subventricular zone morphology 0.0263289246321567 0.0982794864647516 1.22242812219227 0.523809523809524 23.1 23 1 abnormal clavicle morphology 0.0263289246321567 0.0982794864647516 1.22242812219227 0.523809523809524 23.1 23 1 respiratory failure 8.0748916782446e-09 2.3492740408928e-07 1.22095620392353 0.52317880794702 23.1 23 1 decreased sensitivity to induced morbidity/mortality 0.00163641973637902 0.0106507736222676 1.21990244425386 0.522727272727273 23.1 23 1 embryonic lethality, incomplete penetrance 0.00163641973637902 0.0106507736222676 1.21990244425386 0.522727272727273 23.1 23 1 increased lymphocyte cell number 9.58242499095985e-05 0.00098293947072217 1.217596390484 0.521739130434783 23.1 23 1 abnormal lymphocyte physiology 0.00135172351098983 0.00930127865445978 1.217596390484 0.521739130434783 23.1 23 1 abnormal carpal bone morphology 0.0213910754940636 0.0850318588717848 1.217596390484 0.521739130434783 23.1 23 1 abnormal cranial nerve morphology 0.0213910754940636 0.0850318588717848 1.217596390484 0.521739130434783 23.1 23 1 hypotension 0.0213910754940636 0.0850318588717848 1.217596390484 0.521739130434783 23.1 23 1 conjunctivitis 0.0213910754940636 0.0850318588717848 1.217596390484 0.521739130434783 23.1 23 1 abnormal vertebral artery topology 0.0213910754940636 0.0850318588717848 1.217596390484 0.521739130434783 23.1 23 1 enlarged spleen 3.43869484904526e-15 3.42150137480003e-13 1.21548250786164 0.520833333333333 23.1 23 1 abnormal kidney physiology 0.00111709548320485 0.00813671853229475 1.21548250786164 0.520833333333333 23.1 23 1 abnormal phalanx morphology 0.00111709548320485 0.00813671853229475 1.21548250786164 0.520833333333333 23.1 23 1 abnormal seminiferous tubule morphology 2.04256205975433e-08 5.29257617045717e-07 1.21481649004911 0.520547945205479 23.1 23 1 abnormal keratinocyte physiology 0.0174170064482834 0.0717892353605716 1.21353773584906 0.52 23.1 23 1 abnormal cochlear outer hair cell morphology 0.0174170064482834 0.0717892353605716 1.21353773584906 0.52 23.1 23 1 abnormal energy expenditure 0.0174170064482834 0.0717892353605716 1.21353773584906 0.52 23.1 23 1 ataxia 5.12548919583628e-11 2.47566104361995e-09 1.21307561180646 0.51980198019802 23.1 23 1 neonatal lethality, complete penetrance 5.49881725907764e-23 1.36783079319556e-20 1.21292359731877 0.519736842105263 23.1 23 1 abnormal response to infection 3.79758720750089e-05 0.000440396185485243 1.21117446859326 0.518987341772152 23.1 23 1 abnormal rib morphology 8.86477078462836e-08 1.93430853743535e-06 1.21008036338225 0.518518518518518 23.1 23 1 axon degeneration 0.000632161836343873 0.00498416027862245 1.21008036338225 0.518518518518518 23.1 23 1 abnormal brain commissure morphology 0.0142079800649949 0.0599530965422814 1.21008036338225 0.518518518518518 23.1 23 1 abnormal bone trabecula morphology 0.0142079800649949 0.0599530965422814 1.21008036338225 0.518518518518518 23.1 23 1 postnatal lethality 3.36044115510802e-09 1.05145878909826e-07 1.20903898613321 0.518072289156627 23.1 23 1 short tail 2.62528281192069e-05 0.000311713173969103 1.20903898613321 0.518072289156627 23.1 23 1 dermatitis 0.000433332591223057 0.00363546313884437 1.20709986987638 0.517241379310345 23.1 23 1 decreased trophoblast giant cell number 0.0116093739318496 0.0502668714629695 1.20709986987638 0.517241379310345 23.1 23 1 absent long term depression 0.0116093739318496 0.0502668714629695 1.20709986987638 0.517241379310345 23.1 23 1 increased susceptibility to induced arthritis 0.0116093739318496 0.0502668714629695 1.20709986987638 0.517241379310345 23.1 23 1 polychromatophilia 0.0116093739318496 0.0502668714629695 1.20709986987638 0.517241379310345 23.1 23 1 increased leukocyte cell number 3.58401565350497e-08 8.69779408594498e-07 1.20709986987638 0.517241379310345 23.1 23 1 epidermal hyperplasia 0.000358955180656423 0.003057880177681 1.20575864779874 0.516666666666667 23.1 23 1 microphthalmia 1.73732767703073e-08 4.54905536485678e-07 1.20499599210753 0.516339869281046 23.1 23 1 osteopetrosis 0.00949992576276919 0.0449687256610625 1.20450395617772 0.516129032258065 23.1 23 1 decreased neuronal precursor cell number 0.00949992576276919 0.0449687256610625 1.20450395617772 0.516129032258065 23.1 23 1 increased inflammatory response 8.69977302546514e-06 0.000116035846653322 1.20371151936445 0.515789473684211 23.1 23 1 decreased IgM level 7.2399605560845e-06 9.92253547287063e-05 1.20295176035791 0.515463917525773 23.1 23 1 abnormal motor coordination/ balance 6.02572355964233e-06 8.40333740465711e-05 1.20222269868496 0.515151515151515 23.1 23 1 abnormal skin morphology 0.000204405438382963 0.00188735485448296 1.20222269868496 0.515151515151515 23.1 23 1 belly spot 0.00778390536066633 0.0390766187379566 1.20222269868496 0.515151515151515 23.1 23 1 decreased systemic arterial blood pressure 0.00778390536066633 0.0390766187379566 1.20222269868496 0.515151515151515 23.1 23 1 abnormal middle ear ossicle morphology 0.00778390536066633 0.0390766187379566 1.20222269868496 0.515151515151515 23.1 23 1 cardiovascular system phenotype 0.00778390536066633 0.0390766187379566 1.20222269868496 0.515151515151515 23.1 23 1 small testis 6.57254777022878e-14 5.44973752614803e-12 1.20068532950506 0.514492753623188 23.1 23 1 impaired adaptive thermogenesis 0.00638531813747644 0.0329191271854355 1.20020215633423 0.514285714285714 23.1 23 1 decreased bone mineralization 0.00638531813747644 0.0329191271854355 1.20020215633423 0.514285714285714 23.1 23 1 pale liver 9.68372700216419e-05 0.0009912868690487 1.19840005099439 0.513513513513513 23.1 23 1 abnormal vocalization 0.00524355136854673 0.0277517745303404 1.19840005099439 0.513513513513513 23.1 23 1 increased insulin secretion 0.00524355136854673 0.0277517745303404 1.19840005099439 0.513513513513513 23.1 23 1 abnormal chromosome morphology 0.00524355136854673 0.0277517745303404 1.19840005099439 0.513513513513513 23.1 23 1 increased trabecular bone volume 0.00524355136854673 0.0277517745303404 1.19840005099439 0.513513513513513 23.1 23 1 abnormal axial skeleton morphology 8.03861647741323e-05 0.000850896105853847 1.19757013406157 0.513157894736842 23.1 23 1 increased circulating alanine transaminase level 6.67438259241247e-05 0.000714087169833377 1.19678277697146 0.512820512820513 23.1 23 1 acanthosis 0.00431006488260454 0.0232878385731342 1.19678277697146 0.512820512820513 23.1 23 1 abnormal response to injury 0.00431006488260454 0.0232878385731342 1.19678277697146 0.512820512820513 23.1 23 1 increased circulating insulin level 1.46364225203141e-08 3.95740228470449e-07 1.19603478773585 0.5125 23.1 23 1 Leydig cell hyperplasia 0.00354585021681862 0.0205601454879635 1.19532328578003 0.51219512195122 23.1 23 1 lethality at weaning, incomplete penetrance 0.00354585021681862 0.0205601454879635 1.19532328578003 0.51219512195122 23.1 23 1 decreased insulin secretion 2.19523867524641e-05 0.000263799816650988 1.19279350104822 0.511111111111111 23.1 23 1 abnormal cartilage development 0.00240548831482711 0.0145117957475953 1.19279350104822 0.511111111111111 23.1 23 1 altered response to myocardial infarction 0.00240548831482711 0.0145117957475953 1.19279350104822 0.511111111111111 23.1 23 1 albuminuria 0.00240548831482711 0.0145117957475953 1.19279350104822 0.511111111111111 23.1 23 1 abnormal behavior 1.37095887564235e-13 1.04931083174164e-11 1.19204730555178 0.510791366906475 23.1 23 1 hepatic necrosis 0.00198333541566896 0.012318469029904 1.19169008430349 0.51063829787234 23.1 23 1 increased respiratory quotient 0.00198333541566896 0.012318469029904 1.19169008430349 0.51063829787234 23.1 23 1 increased circulating LDL cholesterol level 0.00163628711116422 0.0106507736222676 1.19067674239507 0.510204081632653 23.1 23 1 abnormal epidermis stratum corneum morphology 0.00163628711116422 0.0106507736222676 1.19067674239507 0.510204081632653 23.1 23 1 increased monocyte cell number 8.72769855673058e-06 0.000116097059678435 1.19020047169811 0.51 23.1 23 1 impaired hematopoiesis 0.00135074528584814 0.00930127865445978 1.18974287828339 0.509803921568627 23.1 23 1 abnormal cervical vertebrae morphology 0.00135074528584814 0.00930127865445978 1.18974287828339 0.509803921568627 23.1 23 1 abnormal gluconeogenesis 0.00135074528584814 0.00930127865445978 1.18974287828339 0.509803921568627 23.1 23 1 increased kidney weight 0.00135074528584814 0.00930127865445978 1.18974287828339 0.509803921568627 23.1 23 1 increased macrophage cell number 0.000762166890863879 0.00574512163946636 1.1873344918901 0.508771929824561 23.1 23 1 weight loss 5.91632536913857e-09 1.76249812643499e-07 1.18686657681941 0.508571428571429 23.1 23 1 decreased circulating cholesterol level 2.86370500743212e-09 9.13264898203512e-08 1.18599211258893 0.508196721311475 23.1 23 1 female infertility 9.99238413896895e-13 6.21401388642131e-11 1.18441002269826 0.507518796992481 23.1 23 1 lung inflammation 3.22379531170552e-07 6.3644371729107e-06 1.18402296059933 0.507352941176471 23.1 23 1 corneal opacity 0.000203384129770242 0.00188735485448296 1.18329790061121 0.507042253521127 23.1 23 1 decreased percent body fat/body weight 0.000168622874954709 0.00159486464429596 1.18284763504782 0.506849315068493 23.1 23 1 abnormal spleen morphology 1.01411148474733e-08 2.88960186024589e-07 1.18027542832357 0.505747126436782 23.1 23 1 decreased circulating glucose level 4.81350910780072e-13 3.19296104150781e-11 1.17941012375735 0.505376344086022 23.1 23 1 abnormal T cell differentiation 1.25140103741381e-05 0.000161707017172304 1.17841630861199 0.504950495049505 23.1 23 1 increased B cell number 2.87035297375757e-06 4.38036995228341e-05 1.17683639735527 0.504273504273504 23.1 23 1 increased circulating glucose level 3.19016455093186e-07 6.32313491668766e-06 1.17513883313261 0.50354609929078 23.1 23 1 increased neutrophil cell number 2.21430984363978e-07 4.478126614678e-06 1.17491054001301 0.503448275862069 23.1 23 1 abnormal immune system physiology 2.34582632328672e-06 3.72858976305157e-05 1.16686320754717 0.5 23.1 23 1 abnormal liver physiology 2.13751616134155e-05 0.000257485300306882 1.16686320754717 0.5 23.1 23 1 short femur 6.50275039503137e-05 0.000703286591636544 1.16686320754717 0.5 23.1 23 1 increased T cell number 6.50275039503137e-05 0.000703286591636544 1.16686320754717 0.5 23.1 23 1 abnormal tail morphology 0.000510625249565561 0.00419201421879318 1.16686320754717 0.5 23.1 23 1 decreased eosinophil cell number 0.000616974355262059 0.0049032706348702 1.16686320754717 0.5 23.1 23 1 abnormal long bone epiphyseal plate morphology 0.000901814016253216 0.00668632597743629 1.16686320754717 0.5 23.1 23 1 abnormal spermiogenesis 0.0010910011905047 0.00801732780319188 1.16686320754717 0.5 23.1 23 1 abnormal eye development 0.00132050403715516 0.0091497320123216 1.16686320754717 0.5 23.1 23 1 abnormal neuronal precursor proliferation 0.00159909857115527 0.0105510814210842 1.16686320754717 0.5 23.1 23 1 decreased platelet aggregation 0.00159909857115527 0.0105510814210842 1.16686320754717 0.5 23.1 23 1 abnormal leukocyte migration 0.00193752822578647 0.0120640837588082 1.16686320754717 0.5 23.1 23 1 short stride length 0.00234896348831986 0.0144451092143279 1.16686320754717 0.5 23.1 23 1 decreased circulating alkaline phosphatase level 0.00234896348831986 0.0144451092143279 1.16686320754717 0.5 23.1 23 1 hypertension 0.0042025063463673 0.0232878385731342 1.16686320754717 0.5 23.1 23 1 decreased blood urea nitrogen level 0.0042025063463673 0.0232878385731342 1.16686320754717 0.5 23.1 23 1 abnormal reproductive system physiology 0.00757424124937766 0.0382556854981257 1.16686320754717 0.5 23.1 23 1 reduced long term depression 0.00923620174088706 0.0443106110519895 1.16686320754717 0.5 23.1 23 1 abnormal retinal blood vessel morphology 0.00923620174088706 0.0443106110519895 1.16686320754717 0.5 23.1 23 1 abnormal vision 0.0112762514403823 0.0494282247386805 1.16686320754717 0.5 23.1 23 1 decreased regulatory T cell number 0.0112762514403823 0.0494282247386805 1.16686320754717 0.5 23.1 23 1 neonatal lethality 0.0137851721132018 0.0588175225241673 1.16686320754717 0.5 23.1 23 1 abnormal auditory brainstem response waveform shape 0.0137851721132018 0.0588175225241673 1.16686320754717 0.5 23.1 23 1 abnormal response to new environment 0.016877399001317 0.0699126228405928 1.16686320754717 0.5 23.1 23 1 abnormal optic cup morphology 0.016877399001317 0.0699126228405928 1.16686320754717 0.5 23.1 23 1 abnormal ovulation 0.0206979854797528 0.0836494539088303 1.16686320754717 0.5 23.1 23 1 abnormal respiration 0.0206979854797528 0.0836494539088303 1.16686320754717 0.5 23.1 23 1 abnormal spleen germinal center morphology 0.0206979854797528 0.0836494539088303 1.16686320754717 0.5 23.1 23 1 premature aging 0.0206979854797528 0.0836494539088303 1.16686320754717 0.5 23.1 23 1 abnormal hormone level 0.0206979854797528 0.0836494539088303 1.16686320754717 0.5 23.1 23 1 increased triglyceride level 0.0206979854797528 0.0836494539088303 1.16686320754717 0.5 23.1 23 1 abnormal Schwann cell morphology 0.025432006178663 0.0980048262888059 1.16686320754717 0.5 23.1 23 1 abnormal malleus morphology 0.0313174636941779 0.106403501157254 1.16686320754717 0.5 23.1 23 1 decreased metastatic potential 0.0313174636941779 0.106403501157254 1.16686320754717 0.5 23.1 23 1 hemolytic anemia 0.0313174636941779 0.106403501157254 1.16686320754717 0.5 23.1 23 1 abnormal vasodilation 0.0313174636941779 0.106403501157254 1.16686320754717 0.5 23.1 23 1 apnea 0.0313174636941779 0.106403501157254 1.16686320754717 0.5 23.1 23 1 abnormal primitive streak formation 0.0313174636941779 0.106403501157254 1.16686320754717 0.5 23.1 23 1 decreased ovulation rate 0.0313174636941779 0.106403501157254 1.16686320754717 0.5 23.1 23 1 increased hemangiosarcoma incidence 0.0313174636941779 0.106403501157254 1.16686320754717 0.5 23.1 23 1 increased body temperature 0.0313174636941779 0.106403501157254 1.16686320754717 0.5 23.1 23 1 abnormal enterocyte morphology 0.0386633603438889 0.127892431988595 1.16686320754717 0.5 23.1 23 1 abnormal oogenesis 0.0386633603438889 0.127892431988595 1.16686320754717 0.5 23.1 23 1 abnormal retinal layer morphology 0.0386633603438889 0.127892431988595 1.16686320754717 0.5 23.1 23 1 abnormal limb posture 0.0386633603438889 0.127892431988595 1.16686320754717 0.5 23.1 23 1 abnormal mesenteric lymph node morphology 0.0386633603438889 0.127892431988595 1.16686320754717 0.5 23.1 23 1 abnormal temporal bone morphology 0.0386633603438889 0.127892431988595 1.16686320754717 0.5 23.1 23 1 abnormal sperm midpiece morphology 0.0386633603438889 0.127892431988595 1.16686320754717 0.5 23.1 23 1 abnormal cell proliferation 0.0478756214332745 0.152387214734831 1.16686320754717 0.5 23.1 23 1 increased urine glucose level 0.0478756214332745 0.152387214734831 1.16686320754717 0.5 23.1 23 1 abnormal dopamine level 0.0478756214332745 0.152387214734831 1.16686320754717 0.5 23.1 23 1 abnormal hair texture 0.0478756214332745 0.152387214734831 1.16686320754717 0.5 23.1 23 1 abnormal trachea morphology 0.0478756214332745 0.152387214734831 1.16686320754717 0.5 23.1 23 1 decreased skin tensile strength 0.0478756214332745 0.152387214734831 1.16686320754717 0.5 23.1 23 1 abnormal heart right ventricle morphology 0.0478756214332745 0.152387214734831 1.16686320754717 0.5 23.1 23 1 abnormal optic stalk morphology 0.0478756214332745 0.152387214734831 1.16686320754717 0.5 23.1 23 1 abnormal postnatal subventricular zone morphology 0.0478756214332745 0.152387214734831 1.16686320754717 0.5 23.1 23 1 absent spleen 0.0594954017527453 0.178845694090579 1.16686320754717 0.5 23.1 23 1 abnormal phrenic nerve morphology 0.0594954017527453 0.178845694090579 1.16686320754717 0.5 23.1 23 1 abnormal thymus cortex morphology 0.0594954017527453 0.178845694090579 1.16686320754717 0.5 23.1 23 1 abnormal Peyer's patch follicle morphology 0.0594954017527453 0.178845694090579 1.16686320754717 0.5 23.1 23 1 abnormal white adipose tissue morphology 0.0594954017527453 0.178845694090579 1.16686320754717 0.5 23.1 23 1 acidosis 0.0594954017527453 0.178845694090579 1.16686320754717 0.5 23.1 23 1 decreased heart rate variability 0.0594954017527453 0.178845694090579 1.16686320754717 0.5 23.1 23 1 abnormal neutrophil morphology 0.0594954017527453 0.178845694090579 1.16686320754717 0.5 23.1 23 1 darkened coat color 0.0594954017527453 0.178845694090579 1.16686320754717 0.5 23.1 23 1 abnormal glycogen homeostasis 0.0594954017527453 0.178845694090579 1.16686320754717 0.5 23.1 23 1 abnormal pregnancy 0.0594954017527453 0.178845694090579 1.16686320754717 0.5 23.1 23 1 decreased tumor latency 0.0594954017527453 0.178845694090579 1.16686320754717 0.5 23.1 23 1 increased effector memory CD8-positive, alpha-beta T cell number 0.0594954017527453 0.178845694090579 1.16686320754717 0.5 23.1 23 1 abnormal metanephric mesenchyme morphology 0.0594954017527453 0.178845694090579 1.16686320754717 0.5 23.1 23 1 reduced male mating frequency 0.0742578146312301 0.21146687337743 1.16686320754717 0.5 23.1 23 1 paternal imprinting 0.0742578146312301 0.21146687337743 1.16686320754717 0.5 23.1 23 1 dystonia 0.0742578146312301 0.21146687337743 1.16686320754717 0.5 23.1 23 1 decreased creatinine clearance 0.0742578146312301 0.21146687337743 1.16686320754717 0.5 23.1 23 1 abnormal adrenal gland secretion 0.0931862375512099 0.227144307602778 1.16686320754717 0.5 23.1 23 1 abnormal fluid regulation 0.0931862375512099 0.227144307602778 1.16686320754717 0.5 23.1 23 1 abnormal endplate potential 0.0931862375512099 0.227144307602778 1.16686320754717 0.5 23.1 23 1 abnormal kidney medulla morphology 0.0931862375512099 0.227144307602778 1.16686320754717 0.5 23.1 23 1 decreased vascular permeability 0.0931862375512099 0.227144307602778 1.16686320754717 0.5 23.1 23 1 absent olfactory bulb 0.0931862375512099 0.227144307602778 1.16686320754717 0.5 23.1 23 1 abnormal imprinting 0.0931862375512099 0.227144307602778 1.16686320754717 0.5 23.1 23 1 abnormal pancreas development 0.0931862375512099 0.227144307602778 1.16686320754717 0.5 23.1 23 1 increased lung compliance 0.0931862375512099 0.227144307602778 1.16686320754717 0.5 23.1 23 1 abnormal supraoccipital bone morphology 0.117752964259794 0.276461065215891 1.16686320754717 0.5 23.1 23 1 abnormal mineral level 0.117752964259794 0.276461065215891 1.16686320754717 0.5 23.1 23 1 abnormal rectum morphology 0.117752964259794 0.276461065215891 1.16686320754717 0.5 23.1 23 1 abnormal superior cervical ganglion morphology 0.117752964259794 0.276461065215891 1.16686320754717 0.5 23.1 23 1 abnormal enteric nervous system morphology 0.117752964259794 0.276461065215891 1.16686320754717 0.5 23.1 23 1 increased papilloma incidence 0.117752964259794 0.276461065215891 1.16686320754717 0.5 23.1 23 1 small intestinal inflammation 0.117752964259794 0.276461065215891 1.16686320754717 0.5 23.1 23 1 increased fear-related response 0.117752964259794 0.276461065215891 1.16686320754717 0.5 23.1 23 1 absent ovary 0.117752964259794 0.276461065215891 1.16686320754717 0.5 23.1 23 1 delayed somite formation 0.117752964259794 0.276461065215891 1.16686320754717 0.5 23.1 23 1 decreased left ventricle systolic pressure 0.117752964259794 0.276461065215891 1.16686320754717 0.5 23.1 23 1 increased hepatocyte proliferation 0.117752964259794 0.276461065215891 1.16686320754717 0.5 23.1 23 1 stria vascularis degeneration 0.117752964259794 0.276461065215891 1.16686320754717 0.5 23.1 23 1 hemoperitoneum 0.117752964259794 0.276461065215891 1.16686320754717 0.5 23.1 23 1 abnormal behavioral response to addictive substance 0.117752964259794 0.276461065215891 1.16686320754717 0.5 23.1 23 1 embryonic lethality between implantation and placentation, incomplete penetrance 0.117752964259794 0.276461065215891 1.16686320754717 0.5 23.1 23 1 abnormal colon goblet cell morphology 0.117752964259794 0.276461065215891 1.16686320754717 0.5 23.1 23 1 abnormal lateral semicircular canal morphology 0.150174789733219 0.337300035631046 1.16686320754717 0.5 23.1 23 1 absent maxillary shelf 0.150174789733219 0.337300035631046 1.16686320754717 0.5 23.1 23 1 small petrosal ganglion 0.150174789733219 0.337300035631046 1.16686320754717 0.5 23.1 23 1 enlarged testis 0.150174789733219 0.337300035631046 1.16686320754717 0.5 23.1 23 1 absent trophoblast giant cells 0.150174789733219 0.337300035631046 1.16686320754717 0.5 23.1 23 1 rhinitis 0.150174789733219 0.337300035631046 1.16686320754717 0.5 23.1 23 1 ketoaciduria 0.150174789733219 0.337300035631046 1.16686320754717 0.5 23.1 23 1 decreased circulating parathyroid hormone level 0.150174789733219 0.337300035631046 1.16686320754717 0.5 23.1 23 1 abnormal neuron specification 0.150174789733219 0.337300035631046 1.16686320754717 0.5 23.1 23 1 primary sex reversal 0.150174789733219 0.337300035631046 1.16686320754717 0.5 23.1 23 1 lymphedema 0.150174789733219 0.337300035631046 1.16686320754717 0.5 23.1 23 1 abnormal pillar cell morphology 0.150174789733219 0.337300035631046 1.16686320754717 0.5 23.1 23 1 abnormal placental transport 0.150174789733219 0.337300035631046 1.16686320754717 0.5 23.1 23 1 decreased cochlear inner hair cell number 0.150174789733219 0.337300035631046 1.16686320754717 0.5 23.1 23 1 increased susceptibility to atherosclerosis 0.150174789733219 0.337300035631046 1.16686320754717 0.5 23.1 23 1 tachypnea 0.150174789733219 0.337300035631046 1.16686320754717 0.5 23.1 23 1 abnormal retinal blood vessel pattern 0.150174789733219 0.337300035631046 1.16686320754717 0.5 23.1 23 1 umbilical hernia 0.150174789733219 0.337300035631046 1.16686320754717 0.5 23.1 23 1 decreased trabecular bone connectivity density 0.150174789733219 0.337300035631046 1.16686320754717 0.5 23.1 23 1 abnormal adaptive thermogenesis 0.150174789733219 0.337300035631046 1.16686320754717 0.5 23.1 23 1 abnormal circadian temperature homeostasis 0.150174789733219 0.337300035631046 1.16686320754717 0.5 23.1 23 1 increased fatty acid oxidation 0.150174789733219 0.337300035631046 1.16686320754717 0.5 23.1 23 1 postnatal lethality, complete penetrance 1.1051559524052e-16 1.44688180610944e-14 1.16686320754717 0.5 23.1 23 1 decreased B cell number 1.33581765220506e-09 4.64733763616795e-08 1.16686320754717 0.5 23.1 23 1 increased rib number 0.000165258803144124 0.00156901249168324 1.16686320754717 0.5 23.1 23 1 disheveled coat 0.0051096028161734 0.0272754640445998 1.16686320754717 0.5 23.1 23 1 decreased litter size 2.30025272599071e-12 1.39558015997607e-10 1.16271066944202 0.498220640569395 23.1 23 1 decreased T cell number 1.22843597967426e-07 2.63425387882734e-06 1.15961560998476 0.496894409937888 23.1 23 1 reduced fertility 9.14931578073753e-07 1.63430668121727e-05 1.1584685082123 0.496402877697842 23.1 23 1 hydroencephaly 8.26508385994865e-06 0.000111433041201205 1.1567165709598 0.495652173913044 23.1 23 1 decreased IgG level 1.19449175747571e-05 0.000155565353231457 1.1563509263981 0.495495495495495 23.1 23 1 increased T cell proliferation 1.72718430256881e-05 0.000211643889292606 1.15595794392523 0.495327102803738 23.1 23 1 decreased birth weight 5.23992148703214e-05 0.000575465991125495 1.15458043694141 0.494736842105263 23.1 23 1 abnormal spermatogenesis 2.31985397912671e-08 5.88840487048743e-07 1.15417991181296 0.494565217391304 23.1 23 1 increased sensitivity to induced morbidity/mortality 2.31985397912671e-08 5.88840487048743e-07 1.15417991181296 0.494565217391304 23.1 23 1 increased startle reflex 9.14792803749607e-05 0.000952111757040647 1.15375238499046 0.49438202247191 23.1 23 1 hyperactivity 3.62636956461848e-15 3.53748795764254e-13 1.15113728830799 0.493261455525606 23.1 23 1 abnormal lipid homeostasis 3.18916293468968e-06 4.74413307370609e-05 1.1489114658926 0.492307692307692 23.1 23 1 increased double-negative T cell number 0.00126976187588962 0.00893472791600045 1.14773430250541 0.491803278688525 23.1 23 1 abnormal blood homeostasis 1.38530599093692e-05 0.000176715315510543 1.14639192320424 0.491228070175439 23.1 23 1 abnormal circulating amino acid level 0.0018595881784019 0.0116663949401632 1.14639192320424 0.491228070175439 23.1 23 1 abnormal coat/hair pigmentation 1.66528920225427e-05 0.000205069648049876 1.14602636455526 0.491071428571429 23.1 23 1 increased sensitivity to xenobiotic induced morbidity/mortality 2.00210484004581e-05 0.000242347240370508 1.14564751286449 0.490909090909091 23.1 23 1 abnormal contextual conditioning behavior 0.00225211121375349 0.0139010586705008 1.14564751286449 0.490909090909091 23.1 23 1 abnormal spatial learning 2.38366119095872e-07 4.78173968750791e-06 1.14538719759231 0.49079754601227 23.1 23 1 no abnormal phenotype detected 1.68278615960476e-65 4.18593057201684e-62 1.14466926757653 0.490489913544669 23.1 23 1 abnormal retina morphology 5.06715045514465e-09 1.52782263723301e-07 1.14463724168913 0.49047619047619 23.1 23 1 abnormal enzyme/coenzyme activity 4.11626878484842e-07 8.03075968808663e-06 1.14456645835837 0.490445859872611 23.1 23 1 distended abdomen 0.00330878868300421 0.0193433885992314 1.14398353681095 0.490196078431373 23.1 23 1 decreased circulating creatinine level 0.00401433205562319 0.0225773945084233 1.14304967269927 0.489795918367347 23.1 23 1 increased systemic arterial blood pressure 0.00487367425070164 0.0262124642132331 1.14203633079085 0.48936170212766 23.1 23 1 neuron degeneration 0.00487367425070164 0.0262124642132331 1.14203633079085 0.48936170212766 23.1 23 1 lethality at weaning, complete penetrance 0.00592139315914489 0.0311405189923317 1.14093291404612 0.488888888888889 23.1 23 1 impaired coordination 1.20708139381773e-13 9.53211100673522e-12 1.13988371141891 0.488439306358382 23.1 23 1 abnormal organ of Corti morphology 0.00720019078302819 0.0364746602563461 1.13972685388328 0.488372093023256 23.1 23 1 short humerus 0.00876292675521343 0.0421620508773567 1.13840312931431 0.48780487804878 23.1 23 1 absent gastric milk in neonates 0.000389888839150859 0.00330442414782883 1.13694363812288 0.487179487179487 23.1 23 1 abnormal hair follicle development 0.0130187126199464 0.0557864731130346 1.13532636409995 0.486486486486487 23.1 23 1 abnormal calcium ion homeostasis 0.0130187126199464 0.0557864731130346 1.13532636409995 0.486486486486487 23.1 23 1 decreased circulating thyroxine level 0.01589546622646 0.0661203549135772 1.13352425876011 0.485714285714286 23.1 23 1 decreased sensitivity to xenobiotic induced morbidity/mortality 0.0194334231744118 0.0791820477417679 1.13150371640938 0.484848484848485 23.1 23 1 increased or absent threshold for auditory brainstem response 3.09892788712586e-11 1.55728951903547e-09 1.13052490696612 0.484429065743945 23.1 23 1 abnormal cranial ganglia morphology 0.0237937801624555 0.0933549339970158 1.12922245891662 0.483870967741935 23.1 23 1 abnormal eating behavior 0.00212978152573654 0.0131786854359941 1.1279677672956 0.483333333333333 23.1 23 1 abnormal microglial cell morphology 0.029180689591129 0.103621649333238 1.12662654521796 0.482758620689655 23.1 23 1 decreased granulocyte number 0.029180689591129 0.103621649333238 1.12662654521796 0.482758620689655 23.1 23 1 abnormal spinal nerve morphology 0.029180689591129 0.103621649333238 1.12662654521796 0.482758620689655 23.1 23 1 abnormal neuron differentiation 3.79314006584929e-05 0.000440396185485243 1.12518952156334 0.482142857142857 23.1 23 1 abnormal seminal vesicle morphology 0.00311946961955194 0.0183443987674597 1.12518952156334 0.482142857142857 23.1 23 1 abnormal hair growth 0.0045784742915391 0.0246781252442113 1.12198385341074 0.480769230769231 23.1 23 1 testicular atrophy 0.00555159534851859 0.0292886392989183 1.12018867924528 0.48 23.1 23 1 abnormal thyroid gland morphology 0.0441486549980807 0.143743166633149 1.12018867924528 0.48 23.1 23 1 increased pre-B cell number 0.0441486549980807 0.143743166633149 1.12018867924528 0.48 23.1 23 1 decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 0.0441486549980807 0.143743166633149 1.12018867924528 0.48 23.1 23 1 increased liver glycogen level 0.0441486549980807 0.143743166633149 1.12018867924528 0.48 23.1 23 1 abnormal intestinal epithelium morphology 0.00673584524106471 0.0345828999734746 1.1182439072327 0.479166666666667 23.1 23 1 oligodactyly 0.00673584524106471 0.0345828999734746 1.1182439072327 0.479166666666667 23.1 23 1 abnormal lymph node morphology 0.00673584524106471 0.0345828999734746 1.1182439072327 0.479166666666667 23.1 23 1 abnormal trabecular bone morphology 2.9792692776689e-05 0.000351229020293905 1.11783534168384 0.478991596638655 23.1 23 1 abnormal inner ear morphology 0.00817835486291868 0.039903750305548 1.11613002461034 0.478260869565217 23.1 23 1 abnormal sleep pattern 0.00817835486291868 0.039903750305548 1.11613002461034 0.478260869565217 23.1 23 1 blistering 0.0544962881228952 0.170300900384048 1.11613002461034 0.478260869565217 23.1 23 1 pancreas inflammation 0.0544962881228952 0.170300900384048 1.11613002461034 0.478260869565217 23.1 23 1 increased susceptibility to age related obesity 0.0544962881228952 0.170300900384048 1.11613002461034 0.478260869565217 23.1 23 1 abnormal ulna morphology 0.0544962881228952 0.170300900384048 1.11613002461034 0.478260869565217 23.1 23 1 increased spleen weight 5.15765135948416e-05 0.000567683971536143 1.11523209216898 0.47787610619469 23.1 23 1 increased body weight 1.5955289083867e-08 4.19987106837239e-07 1.11477110006739 0.477678571428571 23.1 23 1 increased total body fat amount 1.12617455341474e-05 0.000147052976462948 1.11461560123909 0.477611940298507 23.1 23 1 abnormal suckling behavior 0.000346475692789615 0.00296171232238545 1.11382397084048 0.477272727272727 23.1 23 1 renal interstitial fibrosis 0.00993720700780551 0.0468602889704573 1.11382397084048 0.477272727272727 23.1 23 1 abnormal amino acid level 0.00993720700780551 0.0468602889704573 1.11382397084048 0.477272727272727 23.1 23 1 lethality, incomplete penetrance 0.00993720700780551 0.0468602889704573 1.11382397084048 0.477272727272727 23.1 23 1 increased food intake 0.000501993089613124 0.00416235936804216 1.11129829290207 0.476190476190476 23.1 23 1 increased circulating aspartate transaminase level 0.0024074179794484 0.0145117957475953 1.11129829290207 0.476190476190476 23.1 23 1 abnormal pancreas morphology 0.012084130336159 0.0522315798630676 1.11129829290207 0.476190476190476 23.1 23 1 abnormal salivary gland morphology 0.0674635276161089 0.199542835844317 1.11129829290207 0.476190476190476 23.1 23 1 trunk curl 0.0674635276161089 0.199542835844317 1.11129829290207 0.476190476190476 23.1 23 1 increased incidence of induced tumors 0.0674635276161089 0.199542835844317 1.11129829290207 0.476190476190476 23.1 23 1 abnormal erythrocyte physiology 0.0674635276161089 0.199542835844317 1.11129829290207 0.476190476190476 23.1 23 1 increased acute inflammation 0.0674635276161089 0.199542835844317 1.11129829290207 0.476190476190476 23.1 23 1 increased bone ossification 0.0674635276161089 0.199542835844317 1.11129829290207 0.476190476190476 23.1 23 1 abnormal gait 5.44131457856486e-11 2.60293654118848e-09 1.11021936252061 0.475728155339806 23.1 23 1 abnormal response/metabolism to endogenous compounds 0.000604408258858766 0.00482653465140026 1.10994305108145 0.475609756097561 23.1 23 1 abnormal male meiosis 0.00290917433341031 0.0171482728776259 1.1094764924219 0.475409836065574 23.1 23 1 abnormal female reproductive system morphology 0.0147079112319288 0.061852796600884 1.10852004716981 0.475 23.1 23 1 abnormal colon morphology 0.0035168979645259 0.020439915155977 1.10753118004477 0.474576271186441 23.1 23 1 increased B cell proliferation 0.0035168979645259 0.020439915155977 1.10753118004477 0.474576271186441 23.1 23 1 impaired natural killer cell mediated cytotoxicity 0.00425336291658695 0.0232878385731342 1.10544935451837 0.473684210526316 23.1 23 1 decreased hair follicle number 0.0179187368534582 0.0737961223890352 1.10544935451837 0.473684210526316 23.1 23 1 small superior vagus ganglion 0.0838016177126635 0.220716775960472 1.10544935451837 0.473684210526316 23.1 23 1 flaky skin 0.0838016177126635 0.220716775960472 1.10544935451837 0.473684210526316 23.1 23 1 unresponsive to tactile stimuli 0.0838016177126635 0.220716775960472 1.10544935451837 0.473684210526316 23.1 23 1 abnormal long term depression 0.0838016177126635 0.220716775960472 1.10544935451837 0.473684210526316 23.1 23 1 increased liver adenoma incidence 0.0838016177126635 0.220716775960472 1.10544935451837 0.473684210526316 23.1 23 1 abnormal photoreceptor inner segment morphology 0.0838016177126635 0.220716775960472 1.10544935451837 0.473684210526316 23.1 23 1 abnormal cochlear inner hair cell morphology 0.0838016177126635 0.220716775960472 1.10544935451837 0.473684210526316 23.1 23 1 absent amnion 0.0838016177126635 0.220716775960472 1.10544935451837 0.473684210526316 23.1 23 1 decreased circulating calcium level 0.00514635376015616 0.0273537499538214 1.10321612349914 0.472727272727273 23.1 23 1 abnormal platelet physiology 0.00514635376015616 0.0273537499538214 1.10321612349914 0.472727272727273 23.1 23 1 abnormal systemic arterial blood pressure 0.0218537555030253 0.0859465878478662 1.10203747379455 0.472222222222222 23.1 23 1 decreased susceptibility to injury 0.00223039402943634 0.0137841121694979 1.09822419533851 0.470588235294118 23.1 23 1 abnormal bone remodeling 0.026684242493549 0.0982794864647516 1.09822419533851 0.470588235294118 23.1 23 1 increased width of hypertrophic chondrocyte zone 0.026684242493549 0.0982794864647516 1.09822419533851 0.470588235294118 23.1 23 1 abnormal urinary bladder morphology 0.104523734558114 0.248687508094988 1.09822419533851 0.470588235294118 23.1 23 1 abnormal duodenum morphology 0.104523734558114 0.248687508094988 1.09822419533851 0.470588235294118 23.1 23 1 abnormal testis development 0.104523734558114 0.248687508094988 1.09822419533851 0.470588235294118 23.1 23 1 increased regulatory T cell number 0.104523734558114 0.248687508094988 1.09822419533851 0.470588235294118 23.1 23 1 decreased growth hormone level 0.104523734558114 0.248687508094988 1.09822419533851 0.470588235294118 23.1 23 1 abnormal survival 0.104523734558114 0.248687508094988 1.09822419533851 0.470588235294118 23.1 23 1 delayed heart development 0.104523734558114 0.248687508094988 1.09822419533851 0.470588235294118 23.1 23 1 improved glucose tolerance 4.20525616665052e-07 8.17232399573685e-06 1.09542260300347 0.469387755102041 23.1 23 1 abnormal long term potentiation 0.0326249049117971 0.109742327204997 1.09393425707547 0.46875 23.1 23 1 increased fatty acid level 0.0326249049117971 0.109742327204997 1.09393425707547 0.46875 23.1 23 1 abnormal cytokine secretion 8.52763206891142e-06 0.000114662079845498 1.09109286939476 0.467532467532468 23.1 23 1 abnormal fat pad morphology 0.0399460688572145 0.131872390553843 1.08907232704403 0.466666666666667 23.1 23 1 macrocytosis 0.131025388359762 0.298877261389187 1.08907232704403 0.466666666666667 23.1 23 1 interdigital webbing 0.131025388359762 0.298877261389187 1.08907232704403 0.466666666666667 23.1 23 1 abnormal enteric neuron morphology 0.131025388359762 0.298877261389187 1.08907232704403 0.466666666666667 23.1 23 1 hyperpigmentation 0.131025388359762 0.298877261389187 1.08907232704403 0.466666666666667 23.1 23 1 abnormal pup retrieval 0.131025388359762 0.298877261389187 1.08907232704403 0.466666666666667 23.1 23 1 no suckling reflex 0.131025388359762 0.298877261389187 1.08907232704403 0.466666666666667 23.1 23 1 abnormal seizure response to electrical stimulation 0.131025388359762 0.298877261389187 1.08907232704403 0.466666666666667 23.1 23 1 increased airway responsiveness 0.131025388359762 0.298877261389187 1.08907232704403 0.466666666666667 23.1 23 1 abnormal respiratory system morphology 0.131025388359762 0.298877261389187 1.08907232704403 0.466666666666667 23.1 23 1 altered righting response 0.131025388359762 0.298877261389187 1.08907232704403 0.466666666666667 23.1 23 1 decreased aggression towards males 0.131025388359762 0.298877261389187 1.08907232704403 0.466666666666667 23.1 23 1 abnormal dendritic cell morphology 0.131025388359762 0.298877261389187 1.08907232704403 0.466666666666667 23.1 23 1 abnormal microglial cell activation 0.131025388359762 0.298877261389187 1.08907232704403 0.466666666666667 23.1 23 1 abnormal ovarian follicle morphology 0.0134510441253835 0.0574905021681983 1.08907232704403 0.466666666666667 23.1 23 1 abnormal ectoderm development 0.0134510441253835 0.0574905021681983 1.08907232704403 0.466666666666667 23.1 23 1 increased circulating cholesterol level 2.50258938365883e-06 3.92756535763491e-05 1.08730435248714 0.465909090909091 23.1 23 1 hyperglycemia 0.000750066746349152 0.00567972916756017 1.08730435248714 0.465909090909091 23.1 23 1 cochlear ganglion degeneration 0.00571347665323168 0.0300788850262726 1.08638988288874 0.46551724137931 23.1 23 1 thrombocytosis 0.00571347665323168 0.0300788850262726 1.08638988288874 0.46551724137931 23.1 23 1 abnormal axon guidance 0.0163310342954032 0.0677622148620774 1.08545414655551 0.465116279069767 23.1 23 1 seizures 0.000148320023935001 0.00142450216037959 1.08497807017544 0.464912280701754 23.1 23 1 reddish skin 0.0489898027147433 0.155634909646135 1.08351583557951 0.464285714285714 23.1 23 1 decreased circulating progesterone level 0.0489898027147433 0.155634909646135 1.08351583557951 0.464285714285714 23.1 23 1 corneal vascularization 0.0489898027147433 0.155634909646135 1.08351583557951 0.464285714285714 23.1 23 1 decreased inflammatory response 0.00108275994113349 0.00796853654902233 1.08351583557951 0.464285714285714 23.1 23 1 arrested B cell differentiation 0.0198422160072738 0.0807154739461872 1.0814829728486 0.463414634146341 23.1 23 1 decreased anxiety-related response 9.52279374609905e-05 0.000980867471777283 1.0814829728486 0.463414634146341 23.1 23 1 reduced male fertility 1.67972554378732e-07 3.49649982441085e-06 1.07947697614496 0.462555066079295 23.1 23 1 abnormal posture 0.00156365526606356 0.0104963226688864 1.07934846698113 0.4625 23.1 23 1 decreased body temperature 0.0100881101150326 0.047526844528681 1.07710449927431 0.461538461538462 23.1 23 1 increased hepatocyte apoptosis 0.0241274751868693 0.0945151094918697 1.07710449927431 0.461538461538462 23.1 23 1 decreased B-1 B cell number 0.0241274751868693 0.0945151094918697 1.07710449927431 0.461538461538462 23.1 23 1 abnormal ocular fundus morphology 0.0601914968432958 0.180610794207115 1.07710449927431 0.461538461538462 23.1 23 1 decreased circulating glycerol level 0.0601914968432958 0.180610794207115 1.07710449927431 0.461538461538462 23.1 23 1 decreased Peyer's patch number 0.0601914968432958 0.180610794207115 1.07710449927431 0.461538461538462 23.1 23 1 abnormal membranous labyrinth morphology 0.16528207145586 0.355964634412513 1.07710449927431 0.461538461538462 23.1 23 1 short hair 0.16528207145586 0.355964634412513 1.07710449927431 0.461538461538462 23.1 23 1 pup cannibalization 0.16528207145586 0.355964634412513 1.07710449927431 0.461538461538462 23.1 23 1 abnormal grip strength 0.16528207145586 0.355964634412513 1.07710449927431 0.461538461538462 23.1 23 1 abnormal digestion 0.16528207145586 0.355964634412513 1.07710449927431 0.461538461538462 23.1 23 1 abnormal intercostal muscle morphology 0.16528207145586 0.355964634412513 1.07710449927431 0.461538461538462 23.1 23 1 anal atresia 0.16528207145586 0.355964634412513 1.07710449927431 0.461538461538462 23.1 23 1 abnormal dopaminergic neuron morphology 0.16528207145586 0.355964634412513 1.07710449927431 0.461538461538462 23.1 23 1 increased circulating ammonia level 0.16528207145586 0.355964634412513 1.07710449927431 0.461538461538462 23.1 23 1 orthokeratosis 0.16528207145586 0.355964634412513 1.07710449927431 0.461538461538462 23.1 23 1 increased bone mineral density 0.000233967812820364 0.00211634521596602 1.07392719986642 0.460176991150442 23.1 23 1 abnormal circulating protein level 0.0122029700259655 0.0526994582284536 1.0735141509434 0.46 23.1 23 1 abnormal long bone metaphysis morphology 0.0293635419536422 0.104122324461418 1.07225267720551 0.459459459459459 23.1 23 1 abnormal pancreatic beta cell physiology 0.0293635419536422 0.104122324461418 1.07225267720551 0.459459459459459 23.1 23 1 abnormal inflammatory response 0.00326528481349978 0.0191115199378369 1.06962460691824 0.458333333333333 23.1 23 1 increased susceptibility to bacterial infection induced morbidity/mortality 0.00326528481349978 0.0191115199378369 1.06962460691824 0.458333333333333 23.1 23 1 blindness 0.0741091395625794 0.21146687337743 1.06962460691824 0.458333333333333 23.1 23 1 abnormal sensory capabilities/reflexes/nociception 0.0741091395625794 0.21146687337743 1.06962460691824 0.458333333333333 23.1 23 1 small lymph nodes 0.0741091395625794 0.21146687337743 1.06962460691824 0.458333333333333 23.1 23 1 abnormal tumor morphology 0.0741091395625794 0.21146687337743 1.06962460691824 0.458333333333333 23.1 23 1 abnormal osteoblast morphology 0.0741091395625794 0.21146687337743 1.06962460691824 0.458333333333333 23.1 23 1 increased circulating HDL cholesterol level 0.000480063202562653 0.0039938368440622 1.06684636118598 0.457142857142857 23.1 23 1 thick epidermis 0.00392634420709787 0.0223496137646589 1.06684636118598 0.457142857142857 23.1 23 1 decreased triglyceride level 0.0357695277710977 0.11999555000756 1.06684636118598 0.457142857142857 23.1 23 1 decreased food intake 0.00246733272061778 0.0147358706903643 1.06347026510628 0.455696202531646 23.1 23 1 reduced long term potentiation 0.000365582404128268 0.00310901275305664 1.0626789925876 0.455357142857143 23.1 23 1 abnormal motor capabilities/coordination/movement 0.000124641551728521 0.00123278671938249 1.06078473413379 0.454545454545455 23.1 23 1 cataract 0.00023302780617656 0.00211370517007858 1.06078473413379 0.454545454545455 23.1 23 1 abnormal photoreceptor outer segment morphology 0.0216592237017345 0.085248922402001 1.06078473413379 0.454545454545455 23.1 23 1 abnormal QRS complex 0.0436178063596182 0.142481015521405 1.06078473413379 0.454545454545455 23.1 23 1 abnormal tail movements 0.0914636670096254 0.223932944573271 1.06078473413379 0.454545454545455 23.1 23 1 intestinal inflammation 0.0914636670096254 0.223932944573271 1.06078473413379 0.454545454545455 23.1 23 1 abnormal blood-brain barrier function 0.0914636670096254 0.223932944573271 1.06078473413379 0.454545454545455 23.1 23 1 decreased susceptibility to viral infection induced morbidity/mortality 0.0914636670096254 0.223932944573271 1.06078473413379 0.454545454545455 23.1 23 1 abnormal thrombopoiesis 0.210194297319728 0.418194358864074 1.06078473413379 0.454545454545455 23.1 23 1 abnormal stomach epithelium morphology 0.210194297319728 0.418194358864074 1.06078473413379 0.454545454545455 23.1 23 1 abnormal sebaceous gland morphology 0.210194297319728 0.418194358864074 1.06078473413379 0.454545454545455 23.1 23 1 abnormal vestibular ganglion morphology 0.210194297319728 0.418194358864074 1.06078473413379 0.454545454545455 23.1 23 1 variable body spotting 0.210194297319728 0.418194358864074 1.06078473413379 0.454545454545455 23.1 23 1 pathological neovascularization 0.210194297319728 0.418194358864074 1.06078473413379 0.454545454545455 23.1 23 1 abnormal hair medulla 0.210194297319728 0.418194358864074 1.06078473413379 0.454545454545455 23.1 23 1 enlarged placenta 0.210194297319728 0.418194358864074 1.06078473413379 0.454545454545455 23.1 23 1 abnormal crista ampullaris neuroepithelium morphology 0.210194297319728 0.418194358864074 1.06078473413379 0.454545454545455 23.1 23 1 increased motor neuron number 0.210194297319728 0.418194358864074 1.06078473413379 0.454545454545455 23.1 23 1 abnormal platelet aggregation 0.210194297319728 0.418194358864074 1.06078473413379 0.454545454545455 23.1 23 1 enhanced behavioral response to addictive substance 0.210194297319728 0.418194358864074 1.06078473413379 0.454545454545455 23.1 23 1 increased number of Howell-Jolly bodies 0.210194297319728 0.418194358864074 1.06078473413379 0.454545454545455 23.1 23 1 increased pancreatic beta cell proliferation 0.210194297319728 0.418194358864074 1.06078473413379 0.454545454545455 23.1 23 1 chylous ascites 0.210194297319728 0.418194358864074 1.06078473413379 0.454545454545455 23.1 23 1 decreased colon length 0.210194297319728 0.418194358864074 1.06078473413379 0.454545454545455 23.1 23 1 increased circulating calcium level 0.0110073921239012 0.0494282247386805 1.06078473413379 0.454545454545455 23.1 23 1 increased circulating bilirubin level 0.0132811914532943 0.0568622439588115 1.05678177287291 0.452830188679245 23.1 23 1 alopecia 0.00117793018935993 0.00853013492294857 1.05631827209533 0.452631578947368 23.1 23 1 abnormal vibrissa morphology 0.02625106938776 0.0982794864647516 1.05573337825696 0.452380952380952 23.1 23 1 abnormal retinal photoreceptor layer morphology 0.053247953664663 0.166924114355197 1.05394096165551 0.451612903225806 23.1 23 1 male infertility 4.11535786997134e-13 2.84359797265381e-11 1.05319263663303 0.451292246520875 23.1 23 1 cochlear inner hair cell degeneration 0.0160289943584134 0.0665644799107736 1.05246485386607 0.450980392156863 23.1 23 1 abnormal thrombosis 0.0160289943584134 0.0665644799107736 1.05246485386607 0.450980392156863 23.1 23 1 abnormal Peyer's patch T cell area morphology 0.113195614668527 0.268165801417107 1.05017688679245 0.45 23.1 23 1 abnormal incus morphology 0.113195614668527 0.268165801417107 1.05017688679245 0.45 23.1 23 1 decreased circulating VLDL cholesterol level 0.113195614668527 0.268165801417107 1.05017688679245 0.45 23.1 23 1 abnormal circulating cytokine level 0.113195614668527 0.268165801417107 1.05017688679245 0.45 23.1 23 1 nuclear cataracts 0.113195614668527 0.268165801417107 1.05017688679245 0.45 23.1 23 1 abnormal heart electrocardiography waveform feature 0.113195614668527 0.268165801417107 1.05017688679245 0.45 23.1 23 1 hyperkeratosis 0.00614520344667437 0.0318130979679552 1.04848578069456 0.449275362318841 23.1 23 1 increased fluid intake 0.019350649660879 0.078909411526945 1.04779553330766 0.448979591836735 23.1 23 1 abnormal enzyme/coenzyme level 0.011897319062518 0.0514688368139365 1.04615322055953 0.448275862068966 23.1 23 1 decreased bone strength 0.0650847071276799 0.193311294304601 1.04615322055953 0.448275862068966 23.1 23 1 increased double-positive T cell number 0.0650847071276799 0.193311294304601 1.04615322055953 0.448275862068966 23.1 23 1 increased retinal apoptosis 0.0650847071276799 0.193311294304601 1.04615322055953 0.448275862068966 23.1 23 1 abnormal retinal pigmentation 0.0024128021352187 0.0145117957475953 1.04615322055953 0.448275862068966 23.1 23 1 increased grooming behavior 0.0386283841776008 0.127892431988595 1.04403550148957 0.447368421052632 23.1 23 1 decreased threshold for auditory brainstem response 0.0386283841776008 0.127892431988595 1.04403550148957 0.447368421052632 23.1 23 1 abnormal innervation 0.0233672652361566 0.0918263385070134 1.04272882376556 0.446808510638298 23.1 23 1 enhanced long term potentiation 0.0143173965125205 0.0603635997032116 1.04184214959569 0.446428571428571 23.1 23 1 decreased monocyte cell number 0.00885352973239418 0.0425568216605421 1.04120101596517 0.446153846153846 23.1 23 1 abnormal T cell activation 0.00551293095746726 0.029115532392144 1.04071583375829 0.445945945945946 23.1 23 1 increased circulating corticosterone level 0.0282257673628155 0.1023727306416 1.03721174004193 0.444444444444444 23.1 23 1 abnormal epidermis stratum granulosum morphology 0.0469021455855557 0.151615921959169 1.03721174004193 0.444444444444444 23.1 23 1 narrow eye opening 0.0469021455855557 0.151615921959169 1.03721174004193 0.444444444444444 23.1 23 1 wrinkled skin 0.0796612414048483 0.220716775960472 1.03721174004193 0.444444444444444 23.1 23 1 decreased susceptibility to pharmacologically induced seizures 0.0796612414048483 0.220716775960472 1.03721174004193 0.444444444444444 23.1 23 1 decreased bone ossification 0.0796612414048483 0.220716775960472 1.03721174004193 0.444444444444444 23.1 23 1 underdeveloped hair follicles 0.140546400802409 0.319277782644743 1.03721174004193 0.444444444444444 23.1 23 1 abnormal radius morphology 0.140546400802409 0.319277782644743 1.03721174004193 0.444444444444444 23.1 23 1 decreased activity of thyroid 0.140546400802409 0.319277782644743 1.03721174004193 0.444444444444444 23.1 23 1 absent ureter 0.140546400802409 0.319277782644743 1.03721174004193 0.444444444444444 23.1 23 1 abnormal anterior eye segment morphology 0.140546400802409 0.319277782644743 1.03721174004193 0.444444444444444 23.1 23 1 increased susceptibility to autoimmune disorder 0.140546400802409 0.319277782644743 1.03721174004193 0.444444444444444 23.1 23 1 decreased fluid intake 0.140546400802409 0.319277782644743 1.03721174004193 0.444444444444444 23.1 23 1 cachexia 0.00146630624831497 0.0100163186144639 1.03222514513788 0.442307692307692 23.1 23 1 decreased IgA level 0.0207407301376465 0.0837541659373307 1.03222514513788 0.442307692307692 23.1 23 1 decreased oxygen consumption 0.0341044305025424 0.114486870276753 1.03118143922773 0.441860465116279 23.1 23 1 abnormal retinal photoreceptor morphology 0.0569864094117778 0.175590380683251 1.02958518312986 0.441176470588235 23.1 23 1 abnormal nervous system development 0.0569864094117778 0.175590380683251 1.02958518312986 0.441176470588235 23.1 23 1 decreased cytotoxic T cell cytolysis 0.0569864094117778 0.175590380683251 1.02958518312986 0.441176470588235 23.1 23 1 increased susceptibility to weight gain 0.0569864094117778 0.175590380683251 1.02958518312986 0.441176470588235 23.1 23 1 abnormal skin physiology 0.0569864094117778 0.175590380683251 1.02958518312986 0.441176470588235 23.1 23 1 arrest of spermatogenesis 0.00440986485905047 0.0237950950908634 1.02795092093441 0.44047619047619 23.1 23 1 increased circulating chloride level 0.0249666836597394 0.0974324577835875 1.02683962264151 0.44 23.1 23 1 abnormal inner ear vestibule morphology 0.0976495202918284 0.236274047571765 1.02683962264151 0.44 23.1 23 1 ruffled hair 0.0976495202918284 0.236274047571765 1.02683962264151 0.44 23.1 23 1 decreased placenta weight 0.0976495202918284 0.236274047571765 1.02683962264151 0.44 23.1 23 1 decreased acute inflammation 0.0976495202918284 0.236274047571765 1.02683962264151 0.44 23.1 23 1 abnormal excitatory postsynaptic potential 0.00526270869541742 0.0278235661633386 1.02456281638288 0.439024390243902 23.1 23 1 increased tumor growth/size 0.0412195716964856 0.135001559703763 1.02456281638288 0.439024390243902 23.1 23 1 abnormal cholesterol homeostasis 0.0412195716964856 0.135001559703763 1.02456281638288 0.439024390243902 23.1 23 1 increased anxiety-related response 0.000358506598692052 0.003057880177681 1.02415331885435 0.438848920863309 23.1 23 1 abnormal lens morphology 0.000668311174183926 0.00521374353082453 1.02100530660377 0.4375 23.1 23 1 abnormal hair shaft morphology 0.030055757726513 0.105526971833461 1.02100530660377 0.4375 23.1 23 1 abnormal lymphatic vessel morphology 0.0692881026946698 0.202053789381839 1.02100530660377 0.4375 23.1 23 1 abnormal serotonin level 0.0692881026946698 0.202053789381839 1.02100530660377 0.4375 23.1 23 1 failure of tooth eruption 0.175177945704176 0.374843131130441 1.02100530660377 0.4375 23.1 23 1 abnormal bone marrow cell number 0.175177945704176 0.374843131130441 1.02100530660377 0.4375 23.1 23 1 abnormal mouth morphology 0.175177945704176 0.374843131130441 1.02100530660377 0.4375 23.1 23 1 disorganized retinal layers 0.175177945704176 0.374843131130441 1.02100530660377 0.4375 23.1 23 1 abnormal extraembryonic endoderm formation 0.175177945704176 0.374843131130441 1.02100530660377 0.4375 23.1 23 1 white spotting 0.175177945704176 0.374843131130441 1.02100530660377 0.4375 23.1 23 1 increased intestinal adenocarcinoma incidence 0.175177945704176 0.374843131130441 1.02100530660377 0.4375 23.1 23 1 decreased cochlear coiling 0.175177945704176 0.374843131130441 1.02100530660377 0.4375 23.1 23 1 decreased aggression towards mice 0.175177945704176 0.374843131130441 1.02100530660377 0.4375 23.1 23 1 abnormal molar crown morphology 0.175177945704176 0.374843131130441 1.02100530660377 0.4375 23.1 23 1 abnormal wound healing 0.175177945704176 0.374843131130441 1.02100530660377 0.4375 23.1 23 1 sepsis 0.175177945704176 0.374843131130441 1.02100530660377 0.4375 23.1 23 1 decreased circulating triiodothyronine level 0.175177945704176 0.374843131130441 1.02100530660377 0.4375 23.1 23 1 abnormal thoracic cage shape 0.175177945704176 0.374843131130441 1.02100530660377 0.4375 23.1 23 1 decreased midbrain size 0.175177945704176 0.374843131130441 1.02100530660377 0.4375 23.1 23 1 small lens 0.0498336320340752 0.156855386051631 1.01726536042574 0.435897435897436 23.1 23 1 abnormal iris morphology 0.0498336320340752 0.156855386051631 1.01726536042574 0.435897435897436 23.1 23 1 abnormal leukocyte adhesion 0.0498336320340752 0.156855386051631 1.01726536042574 0.435897435897436 23.1 23 1 increased autoantibody level 0.0498336320340752 0.156855386051631 1.01726536042574 0.435897435897436 23.1 23 1 abnormal innervation pattern to muscle 0.11990011230711 0.280575286325434 1.01466365873667 0.434782608695652 23.1 23 1 failure of embryo implantation 0.11990011230711 0.280575286325434 1.01466365873667 0.434782608695652 23.1 23 1 abnormal cochlear ganglion morphology 0.11990011230711 0.280575286325434 1.01466365873667 0.434782608695652 23.1 23 1 abnormal sacral vertebrae morphology 0.11990011230711 0.280575286325434 1.01466365873667 0.434782608695652 23.1 23 1 abnormal corneal stroma morphology 0.11990011230711 0.280575286325434 1.01466365873667 0.434782608695652 23.1 23 1 abnormal lens development 0.11990011230711 0.280575286325434 1.01466365873667 0.434782608695652 23.1 23 1 abnormal lipid level 0.00665006276954637 0.0342485116754588 1.01221868606501 0.433734939759036 23.1 23 1 increased erythrocyte cell number 0.0194553186888025 0.0792063915522031 1.01128144654088 0.433333333333333 23.1 23 1 arrested T cell differentiation 0.0843083716874477 0.220716775960472 1.01128144654088 0.433333333333333 23.1 23 1 abnormal pain threshold 0.0843083716874477 0.220716775960472 1.01128144654088 0.433333333333333 23.1 23 1 liver hemorrhage 0.0843083716874477 0.220716775960472 1.01128144654088 0.433333333333333 23.1 23 1 increased susceptibility to parasitic infection 0.00496241272903824 0.0265462401365217 1.01128144654088 0.433333333333333 23.1 23 1 maternal effect 0.0143680139339176 0.0605257149206097 1.01012038862292 0.432835820895522 23.1 23 1 increased erythroid progenitor cell number 0.0602648912098706 0.1806976756521 1.00917899031107 0.432432432432432 23.1 23 1 osteoporosis 0.0435627876711566 0.142394788872539 1.0077454974271 0.431818181818182 23.1 23 1 abnormal circadian rhythm 0.0435627876711566 0.142394788872539 1.0077454974271 0.431818181818182 23.1 23 1 cochlear hair cell degeneration 0.0435627876711566 0.142394788872539 1.0077454974271 0.431818181818182 23.1 23 1 hunched posture 0.00942064904736071 0.0449157909178853 1.00438858371149 0.430379746835443 23.1 23 1 enlarged liver 0.00391048072069702 0.0222848128126777 1.00350235849057 0.43 23.1 23 1 small ovary 0.00620772185519358 0.032103343274 1.00016846361186 0.428571428571429 23.1 23 1 polyuria 0.0112066537946597 0.0494282247386805 1.00016846361186 0.428571428571429 23.1 23 1 abnormal hair follicle morphology 0.0204766587946471 0.0831603081660159 1.00016846361186 0.428571428571429 23.1 23 1 straub tail 0.102664820422427 0.24532059635042 1.00016846361186 0.428571428571429 23.1 23 1 abnormal retinal inner nuclear layer morphology 0.102664820422427 0.24532059635042 1.00016846361186 0.428571428571429 23.1 23 1 enhanced coordination 0.102664820422427 0.24532059635042 1.00016846361186 0.428571428571429 23.1 23 1 abnormal interparietal bone morphology 0.219353946884348 0.423471434128689 1.00016846361186 0.428571428571429 23.1 23 1 abnormal antigen presentation 0.219353946884348 0.423471434128689 1.00016846361186 0.428571428571429 23.1 23 1 failure of zygotic cell division 0.219353946884348 0.423471434128689 1.00016846361186 0.428571428571429 23.1 23 1 abnormal voluntary movement 0.219353946884348 0.423471434128689 1.00016846361186 0.428571428571429 23.1 23 1 abnormal iris pigmentation 0.219353946884348 0.423471434128689 1.00016846361186 0.428571428571429 23.1 23 1 increased circulating growth hormone level 0.219353946884348 0.423471434128689 1.00016846361186 0.428571428571429 23.1 23 1 abnormal glucose tolerance 0.219353946884348 0.423471434128689 1.00016846361186 0.428571428571429 23.1 23 1 increased stomach tumor incidence 0.219353946884348 0.423471434128689 1.00016846361186 0.428571428571429 23.1 23 1 abnormal action potential 0.0151213695624486 0.0633251702363594 1.00016846361186 0.428571428571429 23.1 23 1 decreased urine osmolality 0.0380845887757386 0.127675760889016 1.00016846361186 0.428571428571429 23.1 23 1 abnormal cytotoxic T cell physiology 0.0524459484280295 0.164513615024872 1.00016846361186 0.428571428571429 23.1 23 1 abnormal intestinal goblet cell morphology 0.0728990706422878 0.208672541107815 1.00016846361186 0.428571428571429 23.1 23 1 impaired behavioral response to xenobiotic 0.0728990706422878 0.208672541107815 1.00016846361186 0.428571428571429 23.1 23 1 abnormal eye pigmentation 0.147494679957841 0.334603754122325 1.00016846361186 0.428571428571429 23.1 23 1 abnormal associative learning 0.147494679957841 0.334603754122325 1.00016846361186 0.428571428571429 23.1 23 1 hypoalgesia 0.147494679957841 0.334603754122325 1.00016846361186 0.428571428571429 23.1 23 1 abnormal cochlea morphology 0.033306433041639 0.111883527604425 0.993994584206848 0.425925925925926 23.1 23 1 abnormal small intestine morphology 0.033306433041639 0.111883527604425 0.993994584206848 0.425925925925926 23.1 23 1 small seminal vesicle 0.125118737487419 0.289462753775049 0.987345791001451 0.423076923076923 23.1 23 1 increased susceptibility to otitis media 0.125118737487419 0.289462753775049 0.987345791001451 0.423076923076923 23.1 23 1 abnormal excitatory postsynaptic currents 0.0139321316505117 0.0591525763628818 0.987345791001451 0.423076923076923 23.1 23 1 abnormal metabolism 0.0547706102041749 0.171050712972862 0.985351153039832 0.422222222222222 23.1 23 1 irregular coat pigmentation 0.181815333958588 0.386717095529703 0.982621648460775 0.421052631578947 23.1 23 1 abnormal nail morphology 0.181815333958588 0.386717095529703 0.982621648460775 0.421052631578947 23.1 23 1 short vibrissae 0.181815333958588 0.386717095529703 0.982621648460775 0.421052631578947 23.1 23 1 stereotypic behavior 0.181815333958588 0.386717095529703 0.982621648460775 0.421052631578947 23.1 23 1 altered susceptibility to infection 0.181815333958588 0.386717095529703 0.982621648460775 0.421052631578947 23.1 23 1 abnormal ear morphology 0.181815333958588 0.386717095529703 0.982621648460775 0.421052631578947 23.1 23 1 abnormal neurotransmitter level 0.181815333958588 0.386717095529703 0.982621648460775 0.421052631578947 23.1 23 1 decreased germ cell number 0.181815333958588 0.386717095529703 0.982621648460775 0.421052631578947 23.1 23 1 increased susceptibility to ischemic brain injury 0.181815333958588 0.386717095529703 0.982621648460775 0.421052631578947 23.1 23 1 maternal imprinting 0.181815333958588 0.386717095529703 0.982621648460775 0.421052631578947 23.1 23 1 increased left ventricle weight 0.181815333958588 0.386717095529703 0.982621648460775 0.421052631578947 23.1 23 1 decreased eye pigmentation 0.181815333958588 0.386717095529703 0.982621648460775 0.421052631578947 23.1 23 1 eyelids fail to open 0.181815333958588 0.386717095529703 0.982621648460775 0.421052631578947 23.1 23 1 increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 0.181815333958588 0.386717095529703 0.982621648460775 0.421052631578947 23.1 23 1 increased body length 0.047583761445945 0.152335401025467 0.980165094339623 0.42 23.1 23 1 abnormal CD8-positive, alpha beta T cell morphology 0.106740895815014 0.253841279483602 0.978659464394401 0.419354838709677 23.1 23 1 abnormal male reproductive system morphology 0.0656518413343802 0.194879421622041 0.976908731899956 0.418604651162791 23.1 23 1 increased thermal nociceptive threshold 0.0112053673657467 0.0494282247386805 0.974523118391043 0.417582417582418 23.1 23 1 abnormal locomotor activation 0.0112053673657467 0.0494282247386805 0.974523118391043 0.417582417582418 23.1 23 1 retinal degeneration 0.00985203730356417 0.0465911459935663 0.972386006289308 0.416666666666667 23.1 23 1 curly vibrissae 0.152607949981775 0.342147161405737 0.972386006289308 0.416666666666667 23.1 23 1 hypopigmentation 0.152607949981775 0.342147161405737 0.972386006289308 0.416666666666667 23.1 23 1 increased circulating total protein level 0.152607949981775 0.342147161405737 0.972386006289308 0.416666666666667 23.1 23 1 abnormal cellular extravasation 0.152607949981775 0.342147161405737 0.972386006289308 0.416666666666667 23.1 23 1 decreased digestive secretion 0.276223820933966 0.469136755232335 0.972386006289308 0.416666666666667 23.1 23 1 absent optic nerve 0.276223820933966 0.469136755232335 0.972386006289308 0.416666666666667 23.1 23 1 increased litter size 0.276223820933966 0.469136755232335 0.972386006289308 0.416666666666667 23.1 23 1 abnormal respiratory function 0.276223820933966 0.469136755232335 0.972386006289308 0.416666666666667 23.1 23 1 increased circulating parathyroid hormone level 0.276223820933966 0.469136755232335 0.972386006289308 0.416666666666667 23.1 23 1 small thyroid gland 0.276223820933966 0.469136755232335 0.972386006289308 0.416666666666667 23.1 23 1 abnormal defecation 0.276223820933966 0.469136755232335 0.972386006289308 0.416666666666667 23.1 23 1 abnormal cochlear outer hair cell physiology 0.276223820933966 0.469136755232335 0.972386006289308 0.416666666666667 23.1 23 1 increased placenta weight 0.276223820933966 0.469136755232335 0.972386006289308 0.416666666666667 23.1 23 1 decreased renal glomerular filtration rate 0.276223820933966 0.469136755232335 0.972386006289308 0.416666666666667 23.1 23 1 decreased keratinocyte proliferation 0.276223820933966 0.469136755232335 0.972386006289308 0.416666666666667 23.1 23 1 impaired behavioral response to cocaine 0.276223820933966 0.469136755232335 0.972386006289308 0.416666666666667 23.1 23 1 decreased red blood cell distribution width 0.276223820933966 0.469136755232335 0.972386006289308 0.416666666666667 23.1 23 1 decreased compensatory feeding amount 0.276223820933966 0.469136755232335 0.972386006289308 0.416666666666667 23.1 23 1 obese 0.0203006255007935 0.0825127547928495 0.969860328350894 0.415584415584416 23.1 23 1 scaly skin 0.0786625604547206 0.220716775960472 0.967642659917165 0.414634146341463 23.1 23 1 abnormal CNS synaptic transmission 0.010198017452042 0.0479991833717209 0.966492757766343 0.414141414141414 23.1 23 1 abnormal middle ear morphology 0.12919195921872 0.296462175790189 0.965679895901106 0.413793103448276 23.1 23 1 abnormal circulating glucose level 0.12919195921872 0.296462175790189 0.965679895901106 0.413793103448276 23.1 23 1 aphagia 0.12919195921872 0.296462175790189 0.965679895901106 0.413793103448276 23.1 23 1 abnormal social investigation 0.0209783679883094 0.0842351741257784 0.962662146226415 0.4125 23.1 23 1 decreased osteoblast cell number 0.110054711822917 0.261596842483999 0.960946170921199 0.411764705882353 23.1 23 1 increased aggression towards mice 0.22463589350642 0.432326332763806 0.960946170921199 0.411764705882353 23.1 23 1 abnormal heart rate 0.22463589350642 0.432326332763806 0.960946170921199 0.411764705882353 23.1 23 1 absence seizures 0.22463589350642 0.432326332763806 0.960946170921199 0.411764705882353 23.1 23 1 abnormal involuntary movement 0.22463589350642 0.432326332763806 0.960946170921199 0.411764705882353 23.1 23 1 abnormal melanosome morphology 0.22463589350642 0.432326332763806 0.960946170921199 0.411764705882353 23.1 23 1 increased circulating magnesium level 0.22463589350642 0.432326332763806 0.960946170921199 0.411764705882353 23.1 23 1 abnormal circulating chemokine level 0.22463589350642 0.432326332763806 0.960946170921199 0.411764705882353 23.1 23 1 abnormal NK cell physiology 0.0441338958121955 0.143743166633149 0.956445252087844 0.409836065573771 23.1 23 1 teratozoospermia 0.0189085703385927 0.0771699240643958 0.954706260720412 0.409090909090909 23.1 23 1 testis hypoplasia 0.186285381229683 0.395548344693842 0.954706260720412 0.409090909090909 23.1 23 1 parakeratosis 0.186285381229683 0.395548344693842 0.954706260720412 0.409090909090909 23.1 23 1 abnormal retinal outer plexiform layer morphology 0.186285381229683 0.395548344693842 0.954706260720412 0.409090909090909 23.1 23 1 diluted coat color 0.0602930937854244 0.1806976756521 0.950777428371768 0.407407407407407 23.1 23 1 increased hemoglobin content 0.0522196593085189 0.163907132529894 0.949312440038375 0.406779661016949 23.1 23 1 increased circulating follicle stimulating hormone level 0.132366491107882 0.301659777032391 0.948076356132075 0.40625 23.1 23 1 abnormal lumbar vertebrae morphology 0.132366491107882 0.301659777032391 0.948076356132075 0.40625 23.1 23 1 abnormal epidermal layer morphology 0.0393854609911307 0.130108013566318 0.947019414820891 0.405797101449275 23.1 23 1 abnormal food intake 0.0393854609911307 0.130108013566318 0.947019414820891 0.405797101449275 23.1 23 1 increased brown adipose tissue amount 0.112743356200076 0.267859692977736 0.946105303416624 0.405405405405405 23.1 23 1 abnormal brain wave pattern 0.071439683197833 0.204730658933882 0.942466436865022 0.403846153846154 23.1 23 1 increased percent body fat/body weight 0.071439683197833 0.204730658933882 0.942466436865022 0.403846153846154 23.1 23 1 decreased susceptibility to induced arthritis 0.0617280851779174 0.184886949885695 0.941679079774909 0.403508771929825 23.1 23 1 increased eosinophil cell number 0.0534551921896367 0.167468250090329 0.941018715763847 0.403225806451613 23.1 23 1 cochlear outer hair cell degeneration 0.0403073794554592 0.132188011068497 0.939973139412998 0.402777777777778 23.1 23 1 sparse hair 0.030572486733082 0.105526971833461 0.939182581684307 0.402439024390244 23.1 23 1 impaired righting response 0.023785494074023 0.0933549339970158 0.933490566037736 0.4 23.1 23 1 abnormal skin pigmentation 0.11491437750414 0.272108057155211 0.933490566037736 0.4 23.1 23 1 impaired fertilization 0.0473412409445276 0.15165658319319 0.933490566037736 0.4 23.1 23 1 gastrointestinal hemorrhage 0.159114350906234 0.352921050157074 0.933490566037736 0.4 23.1 23 1 salivary gland inflammation 0.159114350906234 0.352921050157074 0.933490566037736 0.4 23.1 23 1 abnormal estrous cycle 0.159114350906234 0.352921050157074 0.933490566037736 0.4 23.1 23 1 abnormal preimplantation embryo development 0.189246903108406 0.401665248704915 0.933490566037736 0.4 23.1 23 1 abnormal trophectoderm morphology 0.278239652567405 0.469136755232335 0.933490566037736 0.4 23.1 23 1 abnormal Muller cell morphology 0.278239652567405 0.469136755232335 0.933490566037736 0.4 23.1 23 1 abnormal eye electrophysiology 0.0144899520983821 0.0609877425460669 0.925775767971308 0.396694214876033 23.1 23 1 abnormal homeostasis 0.116653174328037 0.276093978250229 0.922636024572181 0.395348837209302 23.1 23 1 abnormal ovarian folliculogenesis 0.161072722700208 0.352921050157074 0.919346769582619 0.393939393939394 23.1 23 1 absent vibrissae 0.161072722700208 0.352921050157074 0.919346769582619 0.393939393939394 23.1 23 1 abnormal stria vascularis morphology 0.191121672034737 0.402682481912701 0.916821091644205 0.392857142857143 23.1 23 1 failure of blastocyst to hatch from the zona pellucida 0.191121672034737 0.402682481912701 0.916821091644205 0.392857142857143 23.1 23 1 decreased epididymis weight 0.228961625537051 0.439303450841308 0.913197292863002 0.391304347826087 23.1 23 1 increased susceptibility to fungal infection 0.228961625537051 0.439303450841308 0.913197292863002 0.391304347826087 23.1 23 1 abnormal hepatocyte physiology 0.228961625537051 0.439303450841308 0.913197292863002 0.391304347826087 23.1 23 1 abnormal megakaryocyte differentiation 0.278147388863517 0.469136755232335 0.907560272536688 0.388888888888889 23.1 23 1 abnormal stomach glandular epithelium morphology 0.278147388863517 0.469136755232335 0.907560272536688 0.388888888888889 23.1 23 1 abnormal iron level 0.278147388863517 0.469136755232335 0.907560272536688 0.388888888888889 23.1 23 1 increased circulating glycerol level 0.278147388863517 0.469136755232335 0.907560272536688 0.388888888888889 23.1 23 1 increased effector memory CD4-positive, alpha-beta T cell number 0.278147388863517 0.469136755232335 0.907560272536688 0.388888888888889 23.1 23 1 impaired leukocyte tethering or rolling 0.278147388863517 0.469136755232335 0.907560272536688 0.388888888888889 23.1 23 1 organ of Corti degeneration 0.119095462578178 0.279481097323789 0.904914324220254 0.387755102040816 23.1 23 1 decreased susceptibility to bacterial infection induced morbidity/mortality 0.192192322542794 0.402682481912701 0.903377967133293 0.387096774193548 23.1 23 1 dehydration 0.0775927730470515 0.219786952307129 0.900151617250674 0.385714285714286 23.1 23 1 abnormal urine homeostasis 0.0451333385603939 0.146853080011746 0.89945705581761 0.385416666666667 23.1 23 1 abnormal leukocyte cell number 0.229327006621523 0.439653895160722 0.897587082728592 0.384615384615385 23.1 23 1 no spontaneous movement 0.229327006621523 0.439653895160722 0.897587082728592 0.384615384615385 23.1 23 1 abnormal mast cell morphology 0.345562414357782 0.516901247376889 0.897587082728592 0.384615384615385 23.1 23 1 uterus hypoplasia 0.345562414357782 0.516901247376889 0.897587082728592 0.384615384615385 23.1 23 1 abnormal afterhyperpolarization 0.345562414357782 0.516901247376889 0.897587082728592 0.384615384615385 23.1 23 1 decreased alcohol consumption 0.345562414357782 0.516901247376889 0.897587082728592 0.384615384615385 23.1 23 1 abnormal insulin secretion 0.345562414357782 0.516901247376889 0.897587082728592 0.384615384615385 23.1 23 1 decreased endocochlear potential 0.345562414357782 0.516901247376889 0.897587082728592 0.384615384615385 23.1 23 1 increased renin activity 0.345562414357782 0.516901247376889 0.897587082728592 0.384615384615385 23.1 23 1 abnormal hair follicle inner root sheath morphology 0.345562414357782 0.516901247376889 0.897587082728592 0.384615384615385 23.1 23 1 abnormal eye physiology 0.103794474839556 0.247900870056069 0.894595125786164 0.383333333333333 23.1 23 1 abnormal oocyte morphology 0.19265530086234 0.402682481912701 0.892307158712542 0.382352941176471 23.1 23 1 abnormal optic nerve morphology 0.163731345820629 0.354312068489617 0.889038634321653 0.380952380952381 23.1 23 1 increased keratinocyte proliferation 0.276833895656036 0.469136755232335 0.889038634321653 0.380952380952381 23.1 23 1 decreased vocalization 0.276833895656036 0.469136755232335 0.889038634321653 0.380952380952381 23.1 23 1 focal hair loss 0.228967607644525 0.439303450841308 0.885206571242681 0.379310344827586 23.1 23 1 decreased retinal photoreceptor cell number 0.228967607644525 0.439303450841308 0.885206571242681 0.379310344827586 23.1 23 1 enlarged epididymis 0.228967607644525 0.439303450841308 0.885206571242681 0.379310344827586 23.1 23 1 decreased osteoclast cell number 0.163873504427397 0.354465515011435 0.881629979035639 0.377777777777778 23.1 23 1 circling 0.0793951221187892 0.220716775960472 0.87857935627081 0.376470588235294 23.1 23 1 increased liver weight 0.0795201772621594 0.220716775960472 0.875147405660377 0.375 23.1 23 1 decreased circulating phosphate level 0.192283554169589 0.402682481912701 0.875147405660377 0.375 23.1 23 1 increased susceptibility to weight loss 0.192283554169589 0.402682481912701 0.875147405660377 0.375 23.1 23 1 increased susceptibility to pharmacologically induced seizures 0.0694833098659985 0.202053789381839 0.875147405660377 0.375 23.1 23 1 increased dopamine level 0.228087821403741 0.438630425776425 0.875147405660377 0.375 23.1 23 1 abnormal retinal ganglion layer morphology 0.274773830870217 0.469136755232335 0.875147405660377 0.375 23.1 23 1 abnormal hair follicle orientation 0.340076676685343 0.516901247376889 0.875147405660377 0.375 23.1 23 1 delayed hair appearance 0.340076676685343 0.516901247376889 0.875147405660377 0.375 23.1 23 1 increased thymus weight 0.340076676685343 0.516901247376889 0.875147405660377 0.375 23.1 23 1 decreased circulating growth hormone level 0.340076676685343 0.516901247376889 0.875147405660377 0.375 23.1 23 1 deafness 0.069556202193817 0.202053789381839 0.872200781398895 0.373737373737374 23.1 23 1 polyphagia 0.16290781750755 0.352921050157074 0.864343116701607 0.37037037037037 23.1 23 1 abnormal nervous system electrophysiology 0.104500980074878 0.248687508094988 0.861256176999102 0.369047619047619 23.1 23 1 hyporesponsive to tactile stimuli 0.225285997685611 0.433409837001514 0.859793942403178 0.368421052631579 23.1 23 1 abnormal response to novelty 0.334341087558058 0.516901247376889 0.859793942403178 0.368421052631579 23.1 23 1 shortened RR interval 0.334341087558058 0.516901247376889 0.859793942403178 0.368421052631579 23.1 23 1 abnormal synaptic transmission 0.269408966808798 0.469136755232335 0.855699685534591 0.366666666666667 23.1 23 1 abnormal gametogenesis 0.221625497886626 0.427690788202468 0.848627787307033 0.363636363636364 23.1 23 1 aphakia 0.328575903899667 0.512755684410554 0.848627787307033 0.363636363636364 23.1 23 1 abnormal coat appearance 0.158549920275781 0.352921050157074 0.845553048947224 0.36231884057971 23.1 23 1 abnormal maternal nurturing 0.184238469150609 0.391703582916359 0.841671821837303 0.360655737704918 23.1 23 1 abnormal nest building behavior 0.322882727736236 0.504029360052643 0.840141509433962 0.36 23.1 23 1 myoclonus 0.317309536822202 0.495640485303125 0.83347371967655 0.357142857142857 23.1 23 1 increased circulating luteinizing hormone level 0.317309536822202 0.495640485303125 0.83347371967655 0.357142857142857 23.1 23 1 abnormal pinna reflex 0.415678229620801 0.605563453107902 0.83347371967655 0.357142857142857 23.1 23 1 abnormal placing response 0.415678229620801 0.605563453107902 0.83347371967655 0.357142857142857 23.1 23 1 decreased coping response 0.415678229620801 0.605563453107902 0.83347371967655 0.357142857142857 23.1 23 1 abnormal prepulse inhibition 0.415678229620801 0.605563453107902 0.83347371967655 0.357142857142857 23.1 23 1 abnormal hair cuticle 0.415678229620801 0.605563453107902 0.83347371967655 0.357142857142857 23.1 23 1 increased B-1 B cell number 0.415678229620801 0.605563453107902 0.83347371967655 0.357142857142857 23.1 23 1 premature hair loss 0.415678229620801 0.605563453107902 0.83347371967655 0.357142857142857 23.1 23 1 abnormal respiratory motile cilium physiology 0.415678229620801 0.605563453107902 0.83347371967655 0.357142857142857 23.1 23 1 decreased pancreatic beta cell number 0.306596815878794 0.479208029845115 0.823668146503885 0.352941176470588 23.1 23 1 increased incidence of corneal inflammation 0.403044376601119 0.588709857190419 0.823668146503885 0.352941176470588 23.1 23 1 aminoaciduria 0.403044376601119 0.588709857190419 0.823668146503885 0.352941176470588 23.1 23 1 increased white adipose tissue amount 0.301466838911325 0.471338002383356 0.819957929627741 0.351351351351351 23.1 23 1 impaired ovarian folliculogenesis 0.29648561414611 0.469136755232335 0.816804245283019 0.35 23.1 23 1 waved hair 0.391837619751084 0.572845183150645 0.816804245283019 0.35 23.1 23 1 abnormal male reproductive system physiology 0.391837619751084 0.572845183150645 0.816804245283019 0.35 23.1 23 1 abnormal thymocyte activation 0.391837619751084 0.572845183150645 0.816804245283019 0.35 23.1 23 1 abnormal crista ampullaris morphology 0.381703519026395 0.558686380451991 0.811730926989335 0.347826086956522 23.1 23 1 abnormal skin condition 0.27794571182086 0.469136755232335 0.807828374455733 0.346153846153846 23.1 23 1 abnormal stomach morphology 0.372412227149907 0.545407957041739 0.807828374455733 0.346153846153846 23.1 23 1 abnormal retinal outer nuclear layer morphology 0.341080876348696 0.516901247376889 0.798380089374379 0.342105263157895 23.1 23 1 impaired swimming 0.318661582456754 0.497596162185296 0.777908805031447 0.333333333333333 23.1 23 1 head tilt 0.390706078001077 0.571694922957458 0.777908805031447 0.333333333333333 23.1 23 1 diarrhea 0.400461335491552 0.585280594615297 0.777908805031447 0.333333333333333 23.1 23 1 abnormal hair cycle 0.411003450127071 0.600159132486697 0.777908805031447 0.333333333333333 23.1 23 1 cryptorchism 0.422497119597236 0.615317087235436 0.777908805031447 0.333333333333333 23.1 23 1 prolonged QT interval 0.435168363104484 0.632105870494835 0.777908805031447 0.333333333333333 23.1 23 1 abnormal anxiety-related response 0.449339481798608 0.646835625563679 0.777908805031447 0.333333333333333 23.1 23 1 dry skin 0.449339481798608 0.646835625563679 0.777908805031447 0.333333333333333 23.1 23 1 decreased cochlear outer hair cell number 0.449339481798608 0.646835625563679 0.777908805031447 0.333333333333333 23.1 23 1 abnormal stapes morphology 0.449339481798608 0.646835625563679 0.777908805031447 0.333333333333333 23.1 23 1 abnormal bile salt homeostasis 0.449339481798608 0.646835625563679 0.777908805031447 0.333333333333333 23.1 23 1 abnormal retinal rod cell morphology 0.46549287046992 0.665751343612167 0.777908805031447 0.333333333333333 23.1 23 1 abnormal macrophage chemotaxis 0.46549287046992 0.665751343612167 0.777908805031447 0.333333333333333 23.1 23 1 abnormal epidermis stratum spinosum morphology 0.4843975181475 0.669225643666652 0.777908805031447 0.333333333333333 23.1 23 1 audiogenic seizures 0.4843975181475 0.669225643666652 0.777908805031447 0.333333333333333 23.1 23 1 increased alcohol consumption 0.4843975181475 0.669225643666652 0.777908805031447 0.333333333333333 23.1 23 1 greasy coat 0.4843975181475 0.669225643666652 0.777908805031447 0.333333333333333 23.1 23 1 abnormal lens fiber morphology 0.38161386794588 0.558686380451991 0.777908805031446 0.333333333333333 23.1 23 1 absent mature ovarian follicles 0.458205987732771 0.659408385585923 0.752814972611077 0.32258064516129 23.1 23 1 abnormal feces composition 0.488008662101308 0.669225643666652 0.746792452830189 0.32 23.1 23 1 intestinal ulcer 0.505695818151447 0.669225643666652 0.742549313893654 0.318181818181818 23.1 23 1 increased activated T cell number 0.505695818151447 0.669225643666652 0.742549313893654 0.318181818181818 23.1 23 1 abnormal channel response 0.505695818151447 0.669225643666652 0.742549313893654 0.318181818181818 23.1 23 1 abnormal female reproductive system physiology 0.505695818151447 0.669225643666652 0.742549313893654 0.318181818181818 23.1 23 1 decreased grooming behavior 0.526024462583087 0.689220885264909 0.736966236345581 0.315789473684211 23.1 23 1 abnormal optic vesicle formation 0.526024462583087 0.689220885264909 0.736966236345581 0.315789473684211 23.1 23 1 decreased fertilization frequency 0.526024462583087 0.689220885264909 0.736966236345581 0.315789473684211 23.1 23 1 abnormal behavioral response to xenobiotic 0.526024462583087 0.689220885264909 0.736966236345581 0.315789473684211 23.1 23 1 decreased circulating magnesium level 0.526024462583087 0.689220885264909 0.736966236345581 0.315789473684211 23.1 23 1 mixed cellular infiltration to dermis 0.549997900630298 0.715702095138431 0.729289504716981 0.3125 23.1 23 1 abnormal meiosis 0.549997900630298 0.715702095138431 0.729289504716981 0.3125 23.1 23 1 decreased circulating prolactin level 0.549997900630298 0.715702095138431 0.729289504716981 0.3125 23.1 23 1 increased circulating estradiol level 0.549997900630298 0.715702095138431 0.729289504716981 0.3125 23.1 23 1 abnormal pancreatic alpha cell morphology 0.549997900630298 0.715702095138431 0.729289504716981 0.3125 23.1 23 1 abnormal Langerhans cell physiology 0.549997900630298 0.715702095138431 0.729289504716981 0.3125 23.1 23 1 abnormal erythrocyte osmotic lysis 0.539384855413042 0.703023226533896 0.718069666182874 0.307692307692308 23.1 23 1 abnormal circulating hormone level 0.518259623627033 0.679942412327133 0.718069666182874 0.307692307692308 23.1 23 1 abnormal T cell subpopulation ratio 0.550119560162685 0.715702095138431 0.707189822755861 0.303030303030303 23.1 23 1 abnormal digestive system physiology 0.553015047412958 0.719281009380253 0.700117924528302 0.3 23.1 23 1 abnormal hearing physiology 0.583533109511089 0.74706053006116 0.700117924528302 0.3 23.1 23 1 decreased paired-pulse facilitation 0.583533109511089 0.74706053006116 0.700117924528302 0.3 23.1 23 1 enhanced behavioral response to xenobiotic 0.583533109511089 0.74706053006116 0.700117924528302 0.3 23.1 23 1 abnormal sperm mitochondrial sheath morphology 0.583533109511089 0.74706053006116 0.700117924528302 0.3 23.1 23 1 abnormal inhibitory postsynaptic currents 0.587331111755232 0.75172942654548 0.686390122086571 0.294117647058824 23.1 23 1 enlarged sebaceous gland 0.611228535642456 0.78182958063986 0.686390122086571 0.294117647058824 23.1 23 1 nephrocalcinosis 0.611228535642456 0.78182958063986 0.686390122086571 0.294117647058824 23.1 23 1 decreased fatty acid level 0.611320013806845 0.78182958063986 0.680670204402516 0.291666666666667 23.1 23 1 abnormal body temperature homeostasis 0.613428377920652 0.784122862321491 0.67753347534997 0.290322580645161 23.1 23 1 autoimmune response 0.613428377920652 0.784122862321491 0.67753347534997 0.290322580645161 23.1 23 1 abnormal crypts of Lieberkuhn morphology 0.655947428111058 0.805019943041752 0.656360554245283 0.28125 23.1 23 1 decreased susceptibility to parasitic infection 0.655947428111058 0.805019943041752 0.656360554245283 0.28125 23.1 23 1 abnormal intestinal mucosa morphology 0.672628402005183 0.816575475835965 0.651272487933304 0.27906976744186 23.1 23 1 abnormal sperm axoneme morphology 0.66728071455497 0.814230157099986 0.648257337526206 0.277777777777778 23.1 23 1 stomach inflammation 0.678523805077043 0.823531576057157 0.643786597267404 0.275862068965517 23.1 23 1 abnormal tectorial membrane morphology 0.703444271023298 0.852114742717533 0.628310957910015 0.269230769230769 23.1 23 1 abnormal coat/ hair morphology 0.760859918424477 0.896135912443602 0.616456034175863 0.264150943396226 23.1 23 1 decreased chemically-elicited antinociception 0.7177293759735 0.869207313891958 0.614138530287984 0.263157894736842 23.1 23 1 bidirectional circling 0.731206050187229 0.885312752417003 0.608798195242002 0.260869565217391 23.1 23 1 abnormal single cell response 0.743639505419296 0.895181526083664 0.605040181691125 0.259259259259259 23.1 23 1 abnormal intestine physiology 0.755157151337591 0.895181526083664 0.602251978088862 0.258064516129032 23.1 23 1 increased urine calcium level 0.762461464794304 0.897809653811044 0.583431603773585 0.25 23.1 23 1 impaired conditioned place preference behavior 0.806502894089294 0.945194793426204 0.560094339622642 0.24 23.1 23 1 head bobbing 0.889039692899628 1 0.525088443396226 0.225 23.1 23 1 abnormal reflex 0.887687195378674 1 0.518605870020964 0.222222222222222 23.1 23 1 head tossing 0.905590730931533 1 0.495032875929102 0.212121212121212 23.1 23 1 thin tail 0.00500284574792584 0.0294546243738829 1.417789181099 1 23.2 23 2 abnormal gustatory system physiology 0.00500284574792584 0.0294546243738829 1.417789181099 1 23.2 23 2 abnormal lymph node cortex morphology 0.00500284574792584 0.0294546243738829 1.417789181099 1 23.2 23 2 abnormal leukocyte tethering or rolling 0.00500284574792584 0.0294546243738829 1.417789181099 1 23.2 23 2 abnormal immature B cell morphology 0.00500284574792584 0.0294546243738829 1.417789181099 1 23.2 23 2 osteomyelitis 0.00500284574792584 0.0294546243738829 1.417789181099 1 23.2 23 2 abnormal eyelid development 0.00500284574792584 0.0294546243738829 1.417789181099 1 23.2 23 2 increased transitional stage T1 B cell number 0.00500284574792584 0.0294546243738829 1.417789181099 1 23.2 23 2 abnormal respiratory epithelium morphology 0.00500284574792584 0.0294546243738829 1.417789181099 1 23.2 23 2 decreased macrophage nitric oxide production 0.00500284574792584 0.0294546243738829 1.417789181099 1 23.2 23 2 thymus cortex atrophy 0.00500284574792584 0.0294546243738829 1.417789181099 1 23.2 23 2 increased bone trabecular spacing 0.00500284574792584 0.0294546243738829 1.417789181099 1 23.2 23 2 abnormal vertebral artery origin 0.00500284574792584 0.0294546243738829 1.417789181099 1 23.2 23 2 decreased capillary density 0.00500284574792584 0.0294546243738829 1.417789181099 1 23.2 23 2 increased cardiac cell glucose uptake 0.00500284574792584 0.0294546243738829 1.417789181099 1 23.2 23 2 reduced sympathetic cervical ganglion size 6.04503250689544e-05 0.0007771068920363 1.417789181099 1 23.2 23 2 abnormal inferior vena cava valve morphology 0.000146217268696136 0.00163835790937675 1.417789181099 1 23.2 23 2 decreased macrophage cytokine production 0.000146217268696136 0.00163835790937675 1.417789181099 1 23.2 23 2 abnormal gut-associated lymphoid tissue morphology 0.000353655588919516 0.00343307721386267 1.417789181099 1 23.2 23 2 premature bone ossification 0.000353655588919516 0.00343307721386267 1.417789181099 1 23.2 23 2 decreased cellular sensitivity to ionizing radiation 0.000353655588919516 0.00343307721386267 1.417789181099 1 23.2 23 2 positive geotaxis 0.000353655588919516 0.00343307721386267 1.417789181099 1 23.2 23 2 increased cardiac muscle glycogen level 0.000353655588919516 0.00343307721386267 1.417789181099 1 23.2 23 2 absent eyelids 0.000855350706253604 0.00717600297405005 1.417789181099 1 23.2 23 2 abnormal eyelid aperture 0.000855350706253604 0.00717600297405005 1.417789181099 1 23.2 23 2 elevated level of mitotic sister chromatid exchange 0.000855350706253604 0.00717600297405005 1.417789181099 1 23.2 23 2 abnormal extraembryonic tissue physiology 0.000855350706253604 0.00717600297405005 1.417789181099 1 23.2 23 2 abnormal kidney epithelium morphology 0.000855350706253604 0.00717600297405005 1.417789181099 1 23.2 23 2 abnormal NK cell morphology 0.000855350706253604 0.00717600297405005 1.417789181099 1 23.2 23 2 abnormal brain ependyma morphology 0.000855350706253604 0.00717600297405005 1.417789181099 1 23.2 23 2 decreased alveolar lamellar body number 0.000855350706253604 0.00717600297405005 1.417789181099 1 23.2 23 2 broad head 0.0020686629994298 0.0149804926086802 1.417789181099 1 23.2 23 2 mammary gland hyperplasia 0.0020686629994298 0.0149804926086802 1.417789181099 1 23.2 23 2 decreased activated T cell number 0.0020686629994298 0.0149804926086802 1.417789181099 1 23.2 23 2 abnormal tumor incidence 0.0020686629994298 0.0149804926086802 1.417789181099 1 23.2 23 2 abnormal hypersensitivity reaction 0.0020686629994298 0.0149804926086802 1.417789181099 1 23.2 23 2 abnormal brain ventricular system morphology 0.0020686629994298 0.0149804926086802 1.417789181099 1 23.2 23 2 abnormal lymph node primary follicle morphology 0.0020686629994298 0.0149804926086802 1.417789181099 1 23.2 23 2 decreased mortality induced by ionizing radiation 0.0020686629994298 0.0149804926086802 1.417789181099 1 23.2 23 2 heart hemorrhage 0.0020686629994298 0.0149804926086802 1.417789181099 1 23.2 23 2 decreased brain cholesterol level 0.0020686629994298 0.0149804926086802 1.417789181099 1 23.2 23 2 decreased T-helper 17 cell number 0.0020686629994298 0.0149804926086802 1.417789181099 1 23.2 23 2 coronary fistula 0.0020686629994298 0.0149804926086802 1.417789181099 1 23.2 23 2 abnormal outer hair cell kinocilium morphology 0.0020686629994298 0.0149804926086802 1.417789181099 1 23.2 23 2 abnormal pineal gland morphology 0.0120983548355837 0.058153927832878 1.417789181099 1 23.2 23 2 absent lungs 0.0120983548355837 0.058153927832878 1.417789181099 1 23.2 23 2 decreased sensitivity to skin irradiation 0.0120983548355837 0.058153927832878 1.417789181099 1 23.2 23 2 skin hyperplasia 0.0120983548355837 0.058153927832878 1.417789181099 1 23.2 23 2 kinked vibrissae 0.0120983548355837 0.058153927832878 1.417789181099 1 23.2 23 2 vascular inflammation 0.0120983548355837 0.058153927832878 1.417789181099 1 23.2 23 2 abnormal respiratory sounds 0.0120983548355837 0.058153927832878 1.417789181099 1 23.2 23 2 cerebral aqueductal stenosis 0.0120983548355837 0.058153927832878 1.417789181099 1 23.2 23 2 increased urine microalbumin level 0.0120983548355837 0.058153927832878 1.417789181099 1 23.2 23 2 epidermal cyst 0.0120983548355837 0.058153927832878 1.417789181099 1 23.2 23 2 ischuria 0.0120983548355837 0.058153927832878 1.417789181099 1 23.2 23 2 abnormal response to vitamins 0.0120983548355837 0.058153927832878 1.417789181099 1 23.2 23 2 increased heart right ventricle weight 0.0120983548355837 0.058153927832878 1.417789181099 1 23.2 23 2 absent frontal bone 0.0120983548355837 0.058153927832878 1.417789181099 1 23.2 23 2 abnormal olfactory cortex morphology 0.0120983548355837 0.058153927832878 1.417789181099 1 23.2 23 2 corneal deposits 0.0120983548355837 0.058153927832878 1.417789181099 1 23.2 23 2 enlarged eye anterior chamber 0.0120983548355837 0.058153927832878 1.417789181099 1 23.2 23 2 palatal shelf fusion with tongue or mandible 0.0120983548355837 0.058153927832878 1.417789181099 1 23.2 23 2 aciduria 0.0120983548355837 0.058153927832878 1.417789181099 1 23.2 23 2 increased response to stress-induced hyperthermia 0.0120983548355837 0.058153927832878 1.417789181099 1 23.2 23 2 increased T follicular helper cell number 0.0120983548355837 0.058153927832878 1.417789181099 1 23.2 23 2 increased thyroid carcinoma incidence 0.0120983548355837 0.058153927832878 1.417789181099 1 23.2 23 2 increased renal carcinoma incidence 0.0120983548355837 0.058153927832878 1.417789181099 1 23.2 23 2 inlet ventricular septal defect 0.0120983548355837 0.058153927832878 1.417789181099 1 23.2 23 2 aorta hypoplasia 0.0120983548355837 0.058153927832878 1.417789181099 1 23.2 23 2 decreased heart left ventricle size 0.0120983548355837 0.058153927832878 1.417789181099 1 23.2 23 2 abnormal blood pressure regulation 0.0120983548355837 0.058153927832878 1.417789181099 1 23.2 23 2 increased Schwann cell number 0.0120983548355837 0.058153927832878 1.417789181099 1 23.2 23 2 increased CD4-positive, alpha-beta memory T cell number 0.0120983548355837 0.058153927832878 1.417789181099 1 23.2 23 2 pale lung 0.0120983548355837 0.058153927832878 1.417789181099 1 23.2 23 2 impaired branching involved in terminal bronchiole morphogenesis 0.0120983548355837 0.058153927832878 1.417789181099 1 23.2 23 2 decreased pre-pro B cell number 0.0120983548355837 0.058153927832878 1.417789181099 1 23.2 23 2 absent nodal flow 0.0120983548355837 0.058153927832878 1.417789181099 1 23.2 23 2 decreased small intestinal villus height 0.0120983548355837 0.058153927832878 1.417789181099 1 23.2 23 2 delayed intramembranous bone ossification 3.93449912148868e-05 0.000542658698586666 1.32326990235906 0.933333333333333 23.2 23 2 abnormal trophectoderm morphology 3.93449912148868e-05 0.000542658698586666 1.32326990235906 0.933333333333333 23.2 23 2 decreased thymocyte apoptosis 3.93449912148868e-05 0.000542658698586666 1.32326990235906 0.933333333333333 23.2 23 2 abnormal ventral body wall morphology 8.91166893841672e-05 0.00108135495045422 1.31651852530621 0.928571428571429 23.2 23 2 abnormal renal tubule epithelial cell primary cilium morphology 8.91166893841672e-05 0.00108135495045422 1.31651852530621 0.928571428571429 23.2 23 2 decreased response to antigen 8.91166893841672e-05 0.00108135495045422 1.31651852530621 0.928571428571429 23.2 23 2 absent hypoglossal nerve 0.000200908123988041 0.00215878599749569 1.30872847486061 0.923076923076923 23.2 23 2 abnormal vascular endothelial cell development 0.000450504920137627 0.00413516970052526 1.29964008267408 0.916666666666667 23.2 23 2 increased osteosarcoma incidence 0.000450504920137627 0.00413516970052526 1.29964008267408 0.916666666666667 23.2 23 2 abnormal fatty acid level 0.000450504920137627 0.00413516970052526 1.29964008267408 0.916666666666667 23.2 23 2 increased fibrosarcoma incidence 0.000450504920137627 0.00413516970052526 1.29964008267408 0.916666666666667 23.2 23 2 abnormal pulmonary valve cusp morphology 0.000450504920137627 0.00413516970052526 1.29964008267408 0.916666666666667 23.2 23 2 prenatal growth retardation 0.000450504920137627 0.00413516970052526 1.29964008267408 0.916666666666667 23.2 23 2 delayed hepatic development 0.00100388670496795 0.00814736763004169 1.28889925554454 0.909090909090909 23.2 23 2 pharyngeal arch hypoplasia 0.00100388670496795 0.00814736763004169 1.28889925554454 0.909090909090909 23.2 23 2 aorta dilation 0.00100388670496795 0.00814736763004169 1.28889925554454 0.909090909090909 23.2 23 2 spleen atrophy 8.7781379467696e-06 0.000140827468143262 1.2760102629891 0.9 23.2 23 2 ketoaciduria 0.00222060047092994 0.0157596110454728 1.2760102629891 0.9 23.2 23 2 abnormal PNS synaptic transmission 0.00222060047092994 0.0157596110454728 1.2760102629891 0.9 23.2 23 2 abnormal tibialis anterior morphology 0.00222060047092994 0.0157596110454728 1.2760102629891 0.9 23.2 23 2 aneurysm 0.00222060047092994 0.0157596110454728 1.2760102629891 0.9 23.2 23 2 abnormal gas homeostasis 0.00222060047092994 0.0157596110454728 1.2760102629891 0.9 23.2 23 2 abnormal respiratory conducting tube morphology 0.00222060047092994 0.0157596110454728 1.2760102629891 0.9 23.2 23 2 osteosclerosis 0.00222060047092994 0.0157596110454728 1.2760102629891 0.9 23.2 23 2 absent inguinal lymph nodes 0.00222060047092994 0.0157596110454728 1.2760102629891 0.9 23.2 23 2 decreased transitional stage T2 B cell number 0.00222060047092994 0.0157596110454728 1.2760102629891 0.9 23.2 23 2 aorta stenosis 0.00222060047092994 0.0157596110454728 1.2760102629891 0.9 23.2 23 2 abnormal left subclavian artery morphology 0.00222060047092994 0.0157596110454728 1.2760102629891 0.9 23.2 23 2 thin ventricle myocardium compact layer 0.00222060047092994 0.0157596110454728 1.2760102629891 0.9 23.2 23 2 abnormal mitotic spindle morphology 1.84337037416679e-07 4.26547330766501e-06 1.26588319740982 0.892857142857143 23.2 23 2 abnormal Peyer's patch follicle morphology 4.17337567758539e-05 0.000565349396306048 1.26025704986577 0.888888888888889 23.2 23 2 decreased cellular sensitivity to gamma-irradiation 4.17337567758539e-05 0.000565349396306048 1.26025704986577 0.888888888888889 23.2 23 2 increased effector memory CD4-positive, alpha-beta T cell number 4.17337567758539e-05 0.000565349396306048 1.26025704986577 0.888888888888889 23.2 23 2 increased effector memory CD8-positive, alpha-beta T cell number 4.17337567758539e-05 0.000565349396306048 1.26025704986577 0.888888888888889 23.2 23 2 abnormal hypoglossal nerve topology 4.17337567758539e-05 0.000565349396306048 1.26025704986577 0.888888888888889 23.2 23 2 heart hyperplasia 0.00486891164492631 0.0292193431043527 1.26025704986577 0.888888888888889 23.2 23 2 distorted hair follicle pattern 0.00486891164492631 0.0292193431043527 1.26025704986577 0.888888888888889 23.2 23 2 decreased level of surface class I molecules 0.00486891164492631 0.0292193431043527 1.26025704986577 0.888888888888889 23.2 23 2 increased pheochromocytoma incidence 0.00486891164492631 0.0292193431043527 1.26025704986577 0.888888888888889 23.2 23 2 premature neuronal precursor differentiation 0.00486891164492631 0.0292193431043527 1.26025704986577 0.888888888888889 23.2 23 2 increased neuronal precursor cell number 0.00486891164492631 0.0292193431043527 1.26025704986577 0.888888888888889 23.2 23 2 decreased transitional stage T1 B cell number 0.00486891164492631 0.0292193431043527 1.26025704986577 0.888888888888889 23.2 23 2 abnormal ventricle myocardium morphology 0.00486891164492631 0.0292193431043527 1.26025704986577 0.888888888888889 23.2 23 2 abnormal pulmonary alveolar system morphology 0.00486891164492631 0.0292193431043527 1.26025704986577 0.888888888888889 23.2 23 2 abnormal lung lobe morphology 0.00486891164492631 0.0292193431043527 1.26025704986577 0.888888888888889 23.2 23 2 abnormal infrahyoid muscle connection 0.00486891164492631 0.0292193431043527 1.26025704986577 0.888888888888889 23.2 23 2 abnormal adipose tissue morphology 9.02050441757469e-05 0.00108924780285034 1.25099045391088 0.882352941176471 23.2 23 2 increased hemangiosarcoma incidence 3.96451314636245e-06 6.94487778280042e-05 1.24056553346162 0.875 23.2 23 2 decreased fibroblast apoptosis 0.000193662354953931 0.00208995708437269 1.24056553346162 0.875 23.2 23 2 increased sensitivity to skin irradiation 0.0105618490516632 0.0534539155971762 1.24056553346162 0.875 23.2 23 2 dermal cysts 0.0105618490516632 0.0534539155971762 1.24056553346162 0.875 23.2 23 2 dry eyes 0.0105618490516632 0.0534539155971762 1.24056553346162 0.875 23.2 23 2 abnormal pulmonary circulation 0.0105618490516632 0.0534539155971762 1.24056553346162 0.875 23.2 23 2 abnormal neuron apoptosis 0.0105618490516632 0.0534539155971762 1.24056553346162 0.875 23.2 23 2 colon polyps 0.0105618490516632 0.0534539155971762 1.24056553346162 0.875 23.2 23 2 liver cysts 0.0105618490516632 0.0534539155971762 1.24056553346162 0.875 23.2 23 2 binucleate 0.0105618490516632 0.0534539155971762 1.24056553346162 0.875 23.2 23 2 abnormal somite size 0.0105618490516632 0.0534539155971762 1.24056553346162 0.875 23.2 23 2 craniofacial phenotype 0.0105618490516632 0.0534539155971762 1.24056553346162 0.875 23.2 23 2 abnormal mitotic spindle assembly checkpoint 0.0105618490516632 0.0534539155971762 1.24056553346162 0.875 23.2 23 2 abnormal base-excision repair 0.0105618490516632 0.0534539155971762 1.24056553346162 0.875 23.2 23 2 pleural effusion 0.0105618490516632 0.0534539155971762 1.24056553346162 0.875 23.2 23 2 abnormal bronchiole epithelium morphology 0.0105618490516632 0.0534539155971762 1.24056553346162 0.875 23.2 23 2 increased airway resistance 0.0105618490516632 0.0534539155971762 1.24056553346162 0.875 23.2 23 2 abnormal foramen magnum morphology 0.0105618490516632 0.0534539155971762 1.24056553346162 0.875 23.2 23 2 abnormal macrophage activation involved in immune response 0.0105618490516632 0.0534539155971762 1.24056553346162 0.875 23.2 23 2 absent Reichert's membrane 0.0105618490516632 0.0534539155971762 1.24056553346162 0.875 23.2 23 2 absent hypoglossal canal 0.0105618490516632 0.0534539155971762 1.24056553346162 0.875 23.2 23 2 abnormal umbilical vein topology 0.0105618490516632 0.0534539155971762 1.24056553346162 0.875 23.2 23 2 increased mammary gland apoptosis 0.0105618490516632 0.0534539155971762 1.24056553346162 0.875 23.2 23 2 increased brain apoptosis 0.0105618490516632 0.0534539155971762 1.24056553346162 0.875 23.2 23 2 decreased basal metabolism 0.0105618490516632 0.0534539155971762 1.24056553346162 0.875 23.2 23 2 decreased B cell proliferation 2.48715412161634e-17 3.45511329859006e-15 1.23832219614976 0.873417721518987 23.2 23 2 inner cell mass degeneration 1.8109087708886e-07 4.20993978279008e-06 1.23484864160235 0.870967741935484 23.2 23 2 preaxial polydactyly 1.8109087708886e-07 4.20993978279008e-06 1.23484864160235 0.870967741935484 23.2 23 2 abnormal hematopoietic stem cell physiology 8.43281332782637e-06 0.000136211838655637 1.23286015747739 0.869565217391304 23.2 23 2 abnormal cell cycle 3.43658067841304e-24 8.54849443755244e-22 1.23286015747739 0.869565217391304 23.2 23 2 abnormal pup retrieval 0.000412632727484488 0.00385149684659536 1.22875062361913 0.866666666666667 23.2 23 2 placental labyrinth hypoplasia 0.000412632727484488 0.00385149684659536 1.22875062361913 0.866666666666667 23.2 23 2 abnormal lymph node B cell domain morphology 0.000412632727484488 0.00385149684659536 1.22875062361913 0.866666666666667 23.2 23 2 abnormal placenta size 0.000412632727484488 0.00385149684659536 1.22875062361913 0.866666666666667 23.2 23 2 immune system phenotype 0.000412632727484488 0.00385149684659536 1.22875062361913 0.866666666666667 23.2 23 2 heterochrony 0.000412632727484488 0.00385149684659536 1.22875062361913 0.866666666666667 23.2 23 2 decreased brown adipose tissue mass 0.000412632727484488 0.00385149684659536 1.22875062361913 0.866666666666667 23.2 23 2 increased B cell proliferation 9.28325521219603e-13 5.92968773546715e-11 1.22554658027201 0.864406779661017 23.2 23 2 intestinal inflammation 1.78334416372138e-05 0.000268515090506023 1.22445429276731 0.863636363636364 23.2 23 2 decreased trophoblast giant cell number 8.07085954731316e-07 1.60048588857391e-05 1.22223205267155 0.862068965517241 23.2 23 2 abnormal lysosome morphology 3.74957156460792e-08 1.02495156779804e-06 1.22087401705747 0.861111111111111 23.2 23 2 increased B cell derived lymphoma incidence 8.46419643857045e-11 3.79363759296288e-09 1.21929869574514 0.86 23.2 23 2 premature aging 1.69134762507263e-06 3.12804997573841e-05 1.21524786951342 0.857142857142857 23.2 23 2 abnormal spleen periarteriolar lymphoid sheath morphology 0.000871656731611278 0.00717962291352004 1.21524786951342 0.857142857142857 23.2 23 2 increased hemangioma incidence 0.000871656731611278 0.00717962291352004 1.21524786951342 0.857142857142857 23.2 23 2 vascular smooth muscle hypoplasia 0.000871656731611278 0.00717962291352004 1.21524786951342 0.857142857142857 23.2 23 2 split sternum 0.000871656731611278 0.00717962291352004 1.21524786951342 0.857142857142857 23.2 23 2 increased B-1 B cell number 0.000871656731611278 0.00717962291352004 1.21524786951342 0.857142857142857 23.2 23 2 lysosomal protein accumulation 0.000871656731611278 0.00717962291352004 1.21524786951342 0.857142857142857 23.2 23 2 cellular necrosis 0.0226079422389021 0.0949579708620601 1.21524786951342 0.857142857142857 23.2 23 2 polyphalangy 0.0226079422389021 0.0949579708620601 1.21524786951342 0.857142857142857 23.2 23 2 absent epidermis stratum corneum 0.0226079422389021 0.0949579708620601 1.21524786951342 0.857142857142857 23.2 23 2 abnormal circulating free fatty acids level 0.0226079422389021 0.0949579708620601 1.21524786951342 0.857142857142857 23.2 23 2 abnormal circulating alanine transaminase level 0.0226079422389021 0.0949579708620601 1.21524786951342 0.857142857142857 23.2 23 2 decreased cardiomyocyte apoptosis 0.0226079422389021 0.0949579708620601 1.21524786951342 0.857142857142857 23.2 23 2 aorta coarctation 0.0226079422389021 0.0949579708620601 1.21524786951342 0.857142857142857 23.2 23 2 decreased tidal volume 0.0226079422389021 0.0949579708620601 1.21524786951342 0.857142857142857 23.2 23 2 absent popliteal lymph nodes 0.0226079422389021 0.0949579708620601 1.21524786951342 0.857142857142857 23.2 23 2 abnormal uterus physiology 0.0226079422389021 0.0949579708620601 1.21524786951342 0.857142857142857 23.2 23 2 abnormal spinal cord central canal morphology 0.0226079422389021 0.0949579708620601 1.21524786951342 0.857142857142857 23.2 23 2 abnormal sperm annulus morphology 0.0226079422389021 0.0949579708620601 1.21524786951342 0.857142857142857 23.2 23 2 decreased DN2 thymocyte number 0.0226079422389021 0.0949579708620601 1.21524786951342 0.857142857142857 23.2 23 2 arteritis 0.0226079422389021 0.0949579708620601 1.21524786951342 0.857142857142857 23.2 23 2 abnormal conotruncal ridge morphology 0.0226079422389021 0.0949579708620601 1.21524786951342 0.857142857142857 23.2 23 2 abnormal aortic valve cusp morphology 0.0226079422389021 0.0949579708620601 1.21524786951342 0.857142857142857 23.2 23 2 increased right ventricle systolic pressure 0.0226079422389021 0.0949579708620601 1.21524786951342 0.857142857142857 23.2 23 2 small lung lobe 0.0226079422389021 0.0949579708620601 1.21524786951342 0.857142857142857 23.2 23 2 small tail bud 0.0226079422389021 0.0949579708620601 1.21524786951342 0.857142857142857 23.2 23 2 absent heart tube 0.0226079422389021 0.0949579708620601 1.21524786951342 0.857142857142857 23.2 23 2 decreased CD8-positive, naive alpha-beta T cell number 0.0226079422389021 0.0949579708620601 1.21524786951342 0.857142857142857 23.2 23 2 decreased areal bone mineral density 0.0226079422389021 0.0949579708620601 1.21524786951342 0.857142857142857 23.2 23 2 abnormal cell differentiation 7.70789525530865e-09 2.49005057760783e-07 1.21030783752353 0.853658536585366 23.2 23 2 increased cellular sensitivity to gamma-irradiation 7.63395354300494e-10 2.83424767734698e-08 1.20662909029702 0.851063829787234 23.2 23 2 abnormal cell morphology 5.36803314179758e-22 1.21390749456559e-19 1.20636447865441 0.850877192982456 23.2 23 2 increased mammary adenocarcinoma incidence 7.82049753398395e-05 0.000970248758892024 1.20512080393415 0.85 23.2 23 2 increased skin tumor incidence 7.82049753398395e-05 0.000970248758892024 1.20512080393415 0.85 23.2 23 2 increased cardiomyocyte apoptosis 3.38771531381475e-07 7.52405521706625e-06 1.20297263850824 0.848484848484849 23.2 23 2 abnormal lymphocyte physiology 1.57820890477219e-09 5.56850305052599e-08 1.20203865354045 0.847826086956522 23.2 23 2 ventricular hypoplasia 7.30566204766314e-06 0.00011916612684303 1.19966776862223 0.846153846153846 23.2 23 2 decreased circulating glycerol level 7.30566204766314e-06 0.00011916612684303 1.19966776862223 0.846153846153846 23.2 23 2 absent teeth 0.00182328729896034 0.0138064753612294 1.19966776862223 0.846153846153846 23.2 23 2 increased foot pad pigmentation 0.00182328729896034 0.0138064753612294 1.19966776862223 0.846153846153846 23.2 23 2 abnormal pulmonary alveolus epithelial cell morphology 0.00182328729896034 0.0138064753612294 1.19966776862223 0.846153846153846 23.2 23 2 abnormal tail bud morphology 0.00182328729896034 0.0138064753612294 1.19966776862223 0.846153846153846 23.2 23 2 abnormal telomere length 0.00182328729896034 0.0138064753612294 1.19966776862223 0.846153846153846 23.2 23 2 abnormal embryonic hematopoiesis 6.98879226855276e-07 1.43083298502263e-05 1.19625962155228 0.84375 23.2 23 2 increased fibroblast apoptosis 6.98879226855276e-07 1.43083298502263e-05 1.19625962155228 0.84375 23.2 23 2 decreased hair follicle number 6.79046016151401e-08 1.75039063748872e-06 1.19392773145179 0.842105263157895 23.2 23 2 increased malignant tumor incidence 0.000161955587283181 0.00179850233645944 1.19392773145179 0.842105263157895 23.2 23 2 decreased tumor incidence 0.000161955587283181 0.00179850233645944 1.19392773145179 0.842105263157895 23.2 23 2 vertebral transformation 2.74055148646762e-09 9.41013146497313e-08 1.18149098424916 0.833333333333333 23.2 23 2 abnormal thymus involution 0.00377079562911959 0.0238369863467217 1.18149098424916 0.833333333333333 23.2 23 2 altered tumor susceptibility 0.00377079562911959 0.0238369863467217 1.18149098424916 0.833333333333333 23.2 23 2 increased growth rate 0.00377079562911959 0.0238369863467217 1.18149098424916 0.833333333333333 23.2 23 2 small intestinal inflammation 0.00377079562911959 0.0238369863467217 1.18149098424916 0.833333333333333 23.2 23 2 abnormal rostral-caudal body axis extension 0.00377079562911959 0.0238369863467217 1.18149098424916 0.833333333333333 23.2 23 2 pale placenta 0.00377079562911959 0.0238369863467217 1.18149098424916 0.833333333333333 23.2 23 2 abnormal cochlear outer hair cell physiology 0.00377079562911959 0.0238369863467217 1.18149098424916 0.833333333333333 23.2 23 2 abnormal B cell proliferation 0.00377079562911959 0.0238369863467217 1.18149098424916 0.833333333333333 23.2 23 2 hematuria 0.00377079562911959 0.0238369863467217 1.18149098424916 0.833333333333333 23.2 23 2 decreased red blood cell distribution width 0.00377079562911959 0.0238369863467217 1.18149098424916 0.833333333333333 23.2 23 2 embryonic lethality between implantation and placentation, incomplete penetrance 0.00377079562911959 0.0238369863467217 1.18149098424916 0.833333333333333 23.2 23 2 abnormal vitelline vein connection 0.00377079562911959 0.0238369863467217 1.18149098424916 0.833333333333333 23.2 23 2 large anterior fontanelle 0.0475759002738729 0.163122056418 1.18149098424916 0.833333333333333 23.2 23 2 hemoglobinuria 0.0475759002738729 0.163122056418 1.18149098424916 0.833333333333333 23.2 23 2 left-sided isomerism 0.0475759002738729 0.163122056418 1.18149098424916 0.833333333333333 23.2 23 2 epidermal necrosis 0.0475759002738729 0.163122056418 1.18149098424916 0.833333333333333 23.2 23 2 abnormal lacrimal gland physiology 0.0475759002738729 0.163122056418 1.18149098424916 0.833333333333333 23.2 23 2 absent ectoplacental cone 0.0475759002738729 0.163122056418 1.18149098424916 0.833333333333333 23.2 23 2 delayed brain development 0.0475759002738729 0.163122056418 1.18149098424916 0.833333333333333 23.2 23 2 non-obstructive hydrocephaly 0.0475759002738729 0.163122056418 1.18149098424916 0.833333333333333 23.2 23 2 abnormal lymph organ size 0.0475759002738729 0.163122056418 1.18149098424916 0.833333333333333 23.2 23 2 abnormal blood gas level 0.0475759002738729 0.163122056418 1.18149098424916 0.833333333333333 23.2 23 2 abnormal cervical lymph node morphology 0.0475759002738729 0.163122056418 1.18149098424916 0.833333333333333 23.2 23 2 abnormal hippocampal fimbria morphology 0.0475759002738729 0.163122056418 1.18149098424916 0.833333333333333 23.2 23 2 delayed tooth eruption 0.0475759002738729 0.163122056418 1.18149098424916 0.833333333333333 23.2 23 2 calcified joint 0.0475759002738729 0.163122056418 1.18149098424916 0.833333333333333 23.2 23 2 esophageal atresia 0.0475759002738729 0.163122056418 1.18149098424916 0.833333333333333 23.2 23 2 pancreas fibrosis 0.0475759002738729 0.163122056418 1.18149098424916 0.833333333333333 23.2 23 2 increased glycerol level 0.0475759002738729 0.163122056418 1.18149098424916 0.833333333333333 23.2 23 2 enlarged pancreas 0.0475759002738729 0.163122056418 1.18149098424916 0.833333333333333 23.2 23 2 abnormal milk ejection 0.0475759002738729 0.163122056418 1.18149098424916 0.833333333333333 23.2 23 2 matted coat 0.0475759002738729 0.163122056418 1.18149098424916 0.833333333333333 23.2 23 2 abnormal cholesterol level 0.0475759002738729 0.163122056418 1.18149098424916 0.833333333333333 23.2 23 2 absent parietal bone 0.0475759002738729 0.163122056418 1.18149098424916 0.833333333333333 23.2 23 2 abnormal blastocoele morphology 0.0475759002738729 0.163122056418 1.18149098424916 0.833333333333333 23.2 23 2 impaired granulocyte bactericidal activity 0.0475759002738729 0.163122056418 1.18149098424916 0.833333333333333 23.2 23 2 abnormal heart size 0.0475759002738729 0.163122056418 1.18149098424916 0.833333333333333 23.2 23 2 increased renal glomerular filtration rate 0.0475759002738729 0.163122056418 1.18149098424916 0.833333333333333 23.2 23 2 abnormal right lung morphology 0.0475759002738729 0.163122056418 1.18149098424916 0.833333333333333 23.2 23 2 absent brachial lymph nodes 0.0475759002738729 0.163122056418 1.18149098424916 0.833333333333333 23.2 23 2 delayed chorioallantoic fusion 0.0475759002738729 0.163122056418 1.18149098424916 0.833333333333333 23.2 23 2 absent sperm mitochondrial sheath 0.0475759002738729 0.163122056418 1.18149098424916 0.833333333333333 23.2 23 2 kidney microaneurysm 0.0475759002738729 0.163122056418 1.18149098424916 0.833333333333333 23.2 23 2 myocardium hypoplasia 0.0475759002738729 0.163122056418 1.18149098424916 0.833333333333333 23.2 23 2 thick pulmonary valve cusps 0.0475759002738729 0.163122056418 1.18149098424916 0.833333333333333 23.2 23 2 absent third pharyngeal arch 0.0475759002738729 0.163122056418 1.18149098424916 0.833333333333333 23.2 23 2 thick myocardium 0.0475759002738729 0.163122056418 1.18149098424916 0.833333333333333 23.2 23 2 abnormal intestinal enteroendocrine cell morphology 0.0475759002738729 0.163122056418 1.18149098424916 0.833333333333333 23.2 23 2 ectopic ureteric bud 0.0475759002738729 0.163122056418 1.18149098424916 0.833333333333333 23.2 23 2 additional anastomosis between intracranial vertebral arteries 0.0475759002738729 0.163122056418 1.18149098424916 0.833333333333333 23.2 23 2 increased body fat mass 0.0475759002738729 0.163122056418 1.18149098424916 0.833333333333333 23.2 23 2 ectopic bone 0.0475759002738729 0.163122056418 1.18149098424916 0.833333333333333 23.2 23 2 decreased tear production 0.0475759002738729 0.163122056418 1.18149098424916 0.833333333333333 23.2 23 2 abnormal trophoblast giant cell morphology 2.83201753132001e-07 6.37028493646301e-06 1.18149098424916 0.833333333333333 23.2 23 2 abnormal mitral valve morphology 0.000332561481175214 0.00326974974080373 1.18149098424916 0.833333333333333 23.2 23 2 abnormal mammary gland morphology 0.000332561481175214 0.00326974974080373 1.18149098424916 0.833333333333333 23.2 23 2 long tibia 0.000332561481175214 0.00326974974080373 1.18149098424916 0.833333333333333 23.2 23 2 absent inner cell mass 0.000332561481175214 0.00326974974080373 1.18149098424916 0.833333333333333 23.2 23 2 thick ventricular wall 5.61948458737295e-08 1.45609040740523e-06 1.17572761359429 0.829268292682927 23.2 23 2 decreased triglyceride level 5.74014730294939e-07 1.18988470134055e-05 1.17473960719631 0.828571428571429 23.2 23 2 increased mortality induced by gamma-irradiation 5.93580364271098e-06 9.87646258277161e-05 1.17334277056469 0.827586206896552 23.2 23 2 abnormal placenta vasculature 1.11340741137215e-09 4.0432130449463e-08 1.17240259206263 0.826923076923077 23.2 23 2 abnormal cell death 1.11952128089773e-08 3.43803603238654e-07 1.17121714960352 0.826086956521739 23.2 23 2 embryonic lethality between implantation and placentation, complete penetrance 1.11952128089773e-08 3.43803603238654e-07 1.17121714960352 0.826086956521739 23.2 23 2 abnormal circulating chemokine level 0.000676463138585458 0.00588501121092037 1.16759109031682 0.823529411764706 23.2 23 2 increased T cell proliferation 4.07350940033077e-18 6.14112402019564e-16 1.16603222370758 0.822429906542056 23.2 23 2 trabecula carnea hypoplasia 2.24840519079302e-08 6.46578949375449e-07 1.16573777112584 0.822222222222222 23.2 23 2 abnormal myocardial trabeculae morphology 2.24840519079302e-08 6.46578949375449e-07 1.16573777112584 0.822222222222222 23.2 23 2 increased bone resorption 1.19619131000775e-05 0.000185970367727768 1.16461254161703 0.821428571428571 23.2 23 2 increased embryonic tissue cell apoptosis 1.86305040905195e-13 1.38338444552738e-11 1.1633141998761 0.82051282051282 23.2 23 2 decreased B-1 B cell number 2.27381731980985e-07 5.14192780275181e-06 1.1633141998761 0.82051282051282 23.2 23 2 pale yolk sac 3.7770252329921e-14 3.13178342235595e-12 1.16156222065942 0.819277108433735 23.2 23 2 abnormal vascular development 1.81378283815429e-11 9.39955168730997e-10 1.16000932999009 0.818181818181818 23.2 23 2 abnormal vascular branching morphogenesis 0.000125863519385595 0.00145621164870543 1.16000932999009 0.818181818181818 23.2 23 2 abnormal occipital bone morphology 0.000125863519385595 0.00145621164870543 1.16000932999009 0.818181818181818 23.2 23 2 increased mammary gland tumor incidence 0.000125863519385595 0.00145621164870543 1.16000932999009 0.818181818181818 23.2 23 2 increased adenoma incidence 0.000125863519385595 0.00145621164870543 1.16000932999009 0.818181818181818 23.2 23 2 abnormal proximal-distal axis patterning 0.00769581241775886 0.0421195454107264 1.16000932999009 0.818181818181818 23.2 23 2 abnormal hair medulla 0.00769581241775886 0.0421195454107264 1.16000932999009 0.818181818181818 23.2 23 2 abnormal spinal cord ventral horn morphology 0.00769581241775886 0.0421195454107264 1.16000932999009 0.818181818181818 23.2 23 2 abnormal dorsal-ventral polarity of the somites 0.00769581241775886 0.0421195454107264 1.16000932999009 0.818181818181818 23.2 23 2 abnormal pulmonary alveolar sac morphology 0.00769581241775886 0.0421195454107264 1.16000932999009 0.818181818181818 23.2 23 2 thin hypoglossal nerve 0.00769581241775886 0.0421195454107264 1.16000932999009 0.818181818181818 23.2 23 2 abnormal atrioventricular cushion morphology 2.39389154909862e-05 0.000350282660493107 1.15523562904363 0.814814814814815 23.2 23 2 thick interventricular septum 2.39389154909862e-05 0.000350282660493107 1.15523562904363 0.814814814814815 23.2 23 2 increased grip strength 6.11852391894799e-15 5.85378009553197e-13 1.15292746594863 0.813186813186813 23.2 23 2 abnormal spongiotrophoblast layer morphology 4.6204404598071e-06 7.79209874153909e-05 1.15195370964293 0.8125 23.2 23 2 pancreatic islet hyperplasia 4.6204404598071e-06 7.79209874153909e-05 1.15195370964293 0.8125 23.2 23 2 abnormal hair follicle orientation 0.00136150434178356 0.0106501322332912 1.15195370964293 0.8125 23.2 23 2 disorganized yolk sac vascular plexus 0.00136150434178356 0.0106501322332912 1.15195370964293 0.8125 23.2 23 2 increased intestinal adenocarcinoma incidence 0.00136150434178356 0.0106501322332912 1.15195370964293 0.8125 23.2 23 2 increased cochlear outer hair cell number 0.00136150434178356 0.0106501322332912 1.15195370964293 0.8125 23.2 23 2 abnormal thoracic cage shape 0.00136150434178356 0.0106501322332912 1.15195370964293 0.8125 23.2 23 2 abnormal chromosome morphology 9.01164618303304e-07 1.7590920416271e-05 1.14955879548567 0.810810810810811 23.2 23 2 abnormal embryonic neuroepithelium morphology 7.04612978529894e-10 2.63567636705731e-08 1.14889812951125 0.810344827586207 23.2 23 2 complete atrioventricular septal defect 0.000251306206224975 0.00262657221842279 1.1477340989849 0.80952380952381 23.2 23 2 embryonic lethality between implantation and somite formation, complete penetrance 7.03129231064087e-37 3.88674213838203e-34 1.14580513411266 0.808163265306122 23.2 23 2 embryonic lethality before implantation, complete penetrance 1.71077760301758e-19 2.93486847414222e-17 1.14557365832799 0.808 23.2 23 2 heart inflammation 4.75507744831923e-05 0.000634222796391104 1.14513741550303 0.807692307692308 23.2 23 2 increased leukemia incidence 4.75507744831923e-05 0.000634222796391104 1.14513741550303 0.807692307692308 23.2 23 2 increased thymocyte apoptosis 4.75507744831923e-05 0.000634222796391104 1.14513741550303 0.807692307692308 23.2 23 2 abnormal T cell proliferation 9.14459594279773e-06 0.000145815271844291 1.14337837185403 0.806451612903226 23.2 23 2 abnormal pharyngeal arch morphology 1.77881134996996e-06 3.26553006129172e-05 1.14210795144086 0.805555555555556 23.2 23 2 increased pre-B cell number 9.36911441885167e-05 0.00112860397660501 1.1342313448792 0.8 23.2 23 2 increased metastatic potential 1.79729698770865e-05 0.000268515090506023 1.1342313448792 0.8 23.2 23 2 abnormal spleen marginal zone morphology 1.79729698770865e-05 0.000268515090506023 1.1342313448792 0.8 23.2 23 2 abnormal brain vasculature morphology 1.79729698770865e-05 0.000268515090506023 1.1342313448792 0.8 23.2 23 2 abnormal pericardium morphology 0.000496958035056548 0.00443871853573847 1.1342313448792 0.8 23.2 23 2 abnormal vascular regression 0.000496958035056548 0.00443871853573847 1.1342313448792 0.8 23.2 23 2 abnormal Peyer's patch T cell area morphology 0.000496958035056548 0.00443871853573847 1.1342313448792 0.8 23.2 23 2 dilated vasculature 0.000496958035056548 0.00443871853573847 1.1342313448792 0.8 23.2 23 2 abnormal response to tactile stimuli 0.000496958035056548 0.00443871853573847 1.1342313448792 0.8 23.2 23 2 absent ductus venosus valve 0.000496958035056548 0.00443871853573847 1.1342313448792 0.8 23.2 23 2 macrocytosis 0.00270775274811845 0.0184282762269347 1.1342313448792 0.8 23.2 23 2 abnormal prostate gland morphology 0.00270775274811845 0.0184282762269347 1.1342313448792 0.8 23.2 23 2 liver vascular congestion 0.00270775274811845 0.0184282762269347 1.1342313448792 0.8 23.2 23 2 abnormal coronary vessel morphology 0.00270775274811845 0.0184282762269347 1.1342313448792 0.8 23.2 23 2 retarded hair growth 0.0154621563409118 0.0703146506362307 1.1342313448792 0.8 23.2 23 2 abnormal prostate gland epithelium morphology 0.0154621563409118 0.0703146506362307 1.1342313448792 0.8 23.2 23 2 abnormal immune cell physiology 0.0154621563409118 0.0703146506362307 1.1342313448792 0.8 23.2 23 2 abnormal respiratory mechanics 0.0154621563409118 0.0703146506362307 1.1342313448792 0.8 23.2 23 2 impaired social transmission of food preference 0.0154621563409118 0.0703146506362307 1.1342313448792 0.8 23.2 23 2 peritoneal inflammation 0.0154621563409118 0.0703146506362307 1.1342313448792 0.8 23.2 23 2 bifid ureter 0.0154621563409118 0.0703146506362307 1.1342313448792 0.8 23.2 23 2 increased heart rate variability 0.0154621563409118 0.0703146506362307 1.1342313448792 0.8 23.2 23 2 abnormal gonadal fat pad morphology 0.0154621563409118 0.0703146506362307 1.1342313448792 0.8 23.2 23 2 increased platelet aggregation 0.0154621563409118 0.0703146506362307 1.1342313448792 0.8 23.2 23 2 absent axillary lymph nodes 0.0154621563409118 0.0703146506362307 1.1342313448792 0.8 23.2 23 2 umbilical hernia 0.0154621563409118 0.0703146506362307 1.1342313448792 0.8 23.2 23 2 acanthocytosis 0.0154621563409118 0.0703146506362307 1.1342313448792 0.8 23.2 23 2 abnormal vibrissa follicle morphology 0.0154621563409118 0.0703146506362307 1.1342313448792 0.8 23.2 23 2 thick aortic valve cusps 0.0154621563409118 0.0703146506362307 1.1342313448792 0.8 23.2 23 2 decreased trabecular bone connectivity density 0.0154621563409118 0.0703146506362307 1.1342313448792 0.8 23.2 23 2 abnormal adaptive thermogenesis 0.0154621563409118 0.0703146506362307 1.1342313448792 0.8 23.2 23 2 decreased macrophage apoptosis 0.0154621563409118 0.0703146506362307 1.1342313448792 0.8 23.2 23 2 lethality during fetal growth through weaning, complete penetrance 0.0154621563409118 0.0703146506362307 1.1342313448792 0.8 23.2 23 2 increased fatty acid oxidation 0.0154621563409118 0.0703146506362307 1.1342313448792 0.8 23.2 23 2 increased sarcoma incidence 5.20318835344234e-08 1.35528073604061e-06 1.12844445026247 0.795918367346939 23.2 23 2 abnormal direction of heart looping 6.80212610846861e-06 0.000111685073893173 1.12589140851979 0.794117647058823 23.2 23 2 abnormal cellular extravasation 0.000182992451219107 0.00200085152706606 1.1224164350367 0.791666666666667 23.2 23 2 abnormal lung saccule morphology 0.000182992451219107 0.00200085152706606 1.1224164350367 0.791666666666667 23.2 23 2 abnormal vitelline vasculature morphology 1.33556534546995e-16 1.62059453505195e-14 1.12190274330442 0.791304347826087 23.2 23 2 abnormal B cell differentiation 2.01475887203549e-13 1.47403314534949e-11 1.12176726416624 0.791208791208791 23.2 23 2 kidney failure 5.08377425107383e-07 1.0754989760963e-05 1.12104260831083 0.790697674418605 23.2 23 2 abnormal double-strand DNA break repair 5.08377425107383e-07 1.0754989760963e-05 1.12104260831083 0.790697674418605 23.2 23 2 abnormal erythropoiesis 3.23619246251201e-15 3.28572602061169e-13 1.12072859077349 0.79047619047619 23.2 23 2 decreased neuron apoptosis 2.57837842028295e-06 4.59764610785221e-05 1.11930724823605 0.789473684210526 23.2 23 2 decreased total retina thickness 2.57837842028295e-06 4.59764610785221e-05 1.11930724823605 0.789473684210526 23.2 23 2 small superior vagus ganglion 0.00097233358327034 0.00793009766683597 1.11930724823605 0.789473684210526 23.2 23 2 abnormal blastocyst morphology 0.00097233358327034 0.00793009766683597 1.11930724823605 0.789473684210526 23.2 23 2 Leydig cell hypoplasia 0.00097233358327034 0.00793009766683597 1.11930724823605 0.789473684210526 23.2 23 2 increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 0.00097233358327034 0.00793009766683597 1.11930724823605 0.789473684210526 23.2 23 2 thin interventricular septum 0.00097233358327034 0.00793009766683597 1.11930724823605 0.789473684210526 23.2 23 2 decreased cell proliferation 1.50565818724277e-25 4.40626440090164e-23 1.11890389427272 0.789189189189189 23.2 23 2 liver hypoplasia 3.86855325334225e-08 1.04032715866906e-06 1.11787223894344 0.788461538461538 23.2 23 2 abnormal leukocyte migration 3.86855325334225e-08 1.04032715866906e-06 1.11787223894344 0.788461538461538 23.2 23 2 kinked neural tube 3.86855325334225e-08 1.04032715866906e-06 1.11787223894344 0.788461538461538 23.2 23 2 lethality throughout fetal growth and development, incomplete penetrance 1.41868029792023e-24 3.71470235902797e-22 1.11680600298859 0.787709497206704 23.2 23 2 neuron degeneration 1.94194084152808e-07 4.45214547769688e-06 1.11613190852474 0.787234042553192 23.2 23 2 spleen hyperplasia 4.67411339488831e-11 2.1937466169405e-09 1.11532748913121 0.786666666666667 23.2 23 2 lymphoid hyperplasia 6.78545909243171e-05 0.000854624278097412 1.11397721372064 0.785714285714286 23.2 23 2 small superior cervical ganglion 6.78545909243171e-05 0.000854624278097412 1.11397721372064 0.785714285714286 23.2 23 2 subcutaneous edema 6.78545909243171e-05 0.000854624278097412 1.11397721372064 0.785714285714286 23.2 23 2 translucent skin 0.00531259937924023 0.0305551235973643 1.11397721372064 0.785714285714286 23.2 23 2 amyloid beta deposits 0.00531259937924023 0.0305551235973643 1.11397721372064 0.785714285714286 23.2 23 2 failure of zygotic cell division 0.00531259937924023 0.0305551235973643 1.11397721372064 0.785714285714286 23.2 23 2 abnormal sagittal suture morphology 0.00531259937924023 0.0305551235973643 1.11397721372064 0.785714285714286 23.2 23 2 abnormal maternal decidual layer morphology 0.00531259937924023 0.0305551235973643 1.11397721372064 0.785714285714286 23.2 23 2 premature hair loss 0.00531259937924023 0.0305551235973643 1.11397721372064 0.785714285714286 23.2 23 2 spina bifida occulta 0.00531259937924023 0.0305551235973643 1.11397721372064 0.785714285714286 23.2 23 2 abnormal placenta labyrinth morphology 1.80947757896518e-11 9.39955168730997e-10 1.11269530668529 0.784810126582278 23.2 23 2 impaired hematopoiesis 7.42325392570346e-08 1.84653441401874e-06 1.11199151458745 0.784313725490196 23.2 23 2 small lung 7.42325392570346e-08 1.84653441401874e-06 1.11199151458745 0.784313725490196 23.2 23 2 abnormal trophoblast layer morphology 7.42325392570346e-08 1.84653441401874e-06 1.11199151458745 0.784313725490196 23.2 23 2 failure of chorioallantoic fusion 7.42325392570346e-08 1.84653441401874e-06 1.11199151458745 0.784313725490196 23.2 23 2 embryonic lethality, complete penetrance 8.92922668518296e-42 5.55286284484815e-39 1.11112004788322 0.783699059561129 23.2 23 2 intracranial hemorrhage 5.70376873238359e-09 1.87922181745751e-07 1.11060152519421 0.783333333333333 23.2 23 2 failure to gastrulate 3.72211023467313e-07 8.1935833705747e-06 1.10957414172965 0.782608695652174 23.2 23 2 abnormal B cell morphology 0.00035402105518924 0.00343307721386267 1.10957414172965 0.782608695652174 23.2 23 2 increased tumor incidence 5.56064650758416e-17 7.09338881416184e-15 1.10907702069841 0.782258064516129 23.2 23 2 decreased circulating total protein level 2.83969701217402e-08 7.92245181913773e-07 1.10845335976831 0.781818181818182 23.2 23 2 increased fatty acid level 2.53022940963357e-05 0.000368660570987057 1.10764779773359 0.78125 23.2 23 2 abnormal humoral immune response 1.68521892147047e-14 1.47087090075712e-12 1.10722583666779 0.780952380952381 23.2 23 2 abnormal embryo development 3.2607962559928e-18 5.06951917923881e-16 1.10504156762128 0.779411764705882 23.2 23 2 lethality throughout fetal growth and development, complete penetrance 8.25938829369278e-25 2.28280315339564e-22 1.1043831515929 0.778947368421053 23.2 23 2 embryonic lethality during organogenesis, complete penetrance 1.79736264069216e-70 4.47093956872175e-67 1.10385014814136 0.778571428571429 23.2 23 2 increased brain weight 0.000130192280955913 0.00148873094788977 1.10272491863255 0.777777777777778 23.2 23 2 decreased circulating fructosamine level 0.000130192280955913 0.00148873094788977 1.10272491863255 0.777777777777778 23.2 23 2 abnormal megakaryocyte differentiation 0.00188011893952132 0.0140655514648399 1.10272491863255 0.777777777777778 23.2 23 2 abnormal thymus cortex morphology 0.00188011893952132 0.0140655514648399 1.10272491863255 0.777777777777778 23.2 23 2 abnormal bile duct morphology 0.00188011893952132 0.0140655514648399 1.10272491863255 0.777777777777778 23.2 23 2 small thoracic cage 0.00188011893952132 0.0140655514648399 1.10272491863255 0.777777777777778 23.2 23 2 impaired leukocyte tethering or rolling 0.00188011893952132 0.0140655514648399 1.10272491863255 0.777777777777778 23.2 23 2 dilated uterus 0.0304871299752422 0.114557002739297 1.10272491863255 0.777777777777778 23.2 23 2 wavy vibrissae 0.0304871299752422 0.114557002739297 1.10272491863255 0.777777777777778 23.2 23 2 abnormal germ cell morphology 0.0304871299752422 0.114557002739297 1.10272491863255 0.777777777777778 23.2 23 2 abnormal NMDA-mediated synaptic currents 0.0304871299752422 0.114557002739297 1.10272491863255 0.777777777777778 23.2 23 2 pancreas cysts 0.0304871299752422 0.114557002739297 1.10272491863255 0.777777777777778 23.2 23 2 abnormal artery development 0.0304871299752422 0.114557002739297 1.10272491863255 0.777777777777778 23.2 23 2 decreased fear-related response 0.0304871299752422 0.114557002739297 1.10272491863255 0.777777777777778 23.2 23 2 abnormal thymus physiology 0.0304871299752422 0.114557002739297 1.10272491863255 0.777777777777778 23.2 23 2 liver hyperplasia 0.0304871299752422 0.114557002739297 1.10272491863255 0.777777777777778 23.2 23 2 hemothorax 0.0304871299752422 0.114557002739297 1.10272491863255 0.777777777777778 23.2 23 2 abnormal inguinal fat pad morphology 0.0304871299752422 0.114557002739297 1.10272491863255 0.777777777777778 23.2 23 2 abnormal leukopoiesis 0.0304871299752422 0.114557002739297 1.10272491863255 0.777777777777778 23.2 23 2 absent cervical lymph nodes 0.0304871299752422 0.114557002739297 1.10272491863255 0.777777777777778 23.2 23 2 abnormal liver vasculature morphology 0.0304871299752422 0.114557002739297 1.10272491863255 0.777777777777778 23.2 23 2 axonal spheroids 0.0304871299752422 0.114557002739297 1.10272491863255 0.777777777777778 23.2 23 2 abnormal telomere morphology 0.0304871299752422 0.114557002739297 1.10272491863255 0.777777777777778 23.2 23 2 prolonged RR interval 0.0304871299752422 0.114557002739297 1.10272491863255 0.777777777777778 23.2 23 2 decreased effector memory CD4-positive, alpha-beta T cell number 0.0304871299752422 0.114557002739297 1.10272491863255 0.777777777777778 23.2 23 2 reduced AMPA-mediated synaptic currents 0.0304871299752422 0.114557002739297 1.10272491863255 0.777777777777778 23.2 23 2 increased core body temperature 0.0304871299752422 0.114557002739297 1.10272491863255 0.777777777777778 23.2 23 2 trigeminal neuroma 0.0304871299752422 0.114557002739297 1.10272491863255 0.777777777777778 23.2 23 2 symmetric azygos veins 0.0304871299752422 0.114557002739297 1.10272491863255 0.777777777777778 23.2 23 2 cerebellum atrophy 0.0304871299752422 0.114557002739297 1.10272491863255 0.777777777777778 23.2 23 2 abnormal CD4-positive, alpha-beta T cell physiology 6.12308016471946e-10 2.3253682304946e-08 1.09828739380908 0.774647887323944 23.2 23 2 pericardial effusion 7.88119282564592e-09 2.52960866500571e-07 1.09764323697987 0.774193548387097 23.2 23 2 abnormal object recognition memory 4.82416805089334e-05 0.000638304150350915 1.09764323697987 0.774193548387097 23.2 23 2 increased lung adenoma incidence 4.82416805089334e-05 0.000638304150350915 1.09764323697987 0.774193548387097 23.2 23 2 pale kidney 4.82416805089334e-05 0.000638304150350915 1.09764323697987 0.774193548387097 23.2 23 2 atrioventricular septal defect 1.02311302332575e-07 2.52991427739221e-06 1.09678030990677 0.773584905660377 23.2 23 2 preweaning lethality, complete penetrance 4.21725023453722e-90 2.09808199168227e-86 1.09591271836301 0.772972972972973 23.2 23 2 embryonic growth arrest 1.19724061102635e-28 4.9635600332134e-26 1.09584578626429 0.77292576419214 23.2 23 2 abnormal lysosome physiology 0.000677811341478869 0.00588501121092037 1.09556436721286 0.772727272727273 23.2 23 2 abnormal sperm midpiece morphology 0.000677811341478869 0.00588501121092037 1.09556436721286 0.772727272727273 23.2 23 2 decreased embryo size 4.56973333020569e-58 4.54688466355467e-55 1.09448579042998 0.771966527196653 23.2 23 2 incomplete embryo turning 3.89500131958991e-08 1.04180814865375e-06 1.0944337538308 0.771929824561403 23.2 23 2 decreased B cell number 9.19883976724071e-26 3.0509485228015e-23 1.09431300871233 0.771844660194175 23.2 23 2 domed cranium 1.15390063533837e-09 4.15989540638288e-08 1.09372308256208 0.771428571428571 23.2 23 2 abnormal neural tube closure 3.46628818637254e-11 1.70740432942608e-09 1.09323503120886 0.771084337349398 23.2 23 2 overriding aortic valve 5.08414545039935e-07 1.0754989760963e-05 1.09287916043048 0.770833333333333 23.2 23 2 small heart 5.08414545039935e-07 1.0754989760963e-05 1.09287916043048 0.770833333333333 23.2 23 2 abnormal angiogenesis 4.42057415744368e-10 1.71815284635018e-08 1.09208085571139 0.77027027027027 23.2 23 2 kidney cysts 4.42057415744368e-10 1.71815284635018e-08 1.09208085571139 0.77027027027027 23.2 23 2 decreased double-positive T cell number 4.04739440894904e-13 2.75832701157828e-11 1.09169766944623 0.77 23.2 23 2 small liver 1.69469422768237e-10 7.14500320569474e-09 1.09060706238384 0.769230769230769 23.2 23 2 distended pericardium 1.92722561669074e-07 4.43886455696132e-06 1.09060706238384 0.769230769230769 23.2 23 2 decreased Peyer's patch number 0.000247492376539598 0.00259762568203481 1.09060706238384 0.769230769230769 23.2 23 2 abnormal grip strength 0.0102624900629837 0.0532386736844045 1.09060706238384 0.769230769230769 23.2 23 2 abnormal exocrine pancreas morphology 0.0102624900629837 0.0532386736844045 1.09060706238384 0.769230769230769 23.2 23 2 orthokeratosis 0.0102624900629837 0.0532386736844045 1.09060706238384 0.769230769230769 23.2 23 2 empty decidua capsularis 0.0102624900629837 0.0532386736844045 1.09060706238384 0.769230769230769 23.2 23 2 decreased spleen weight 2.1657908833113e-09 7.53483191921239e-08 1.08902647243836 0.768115942028985 23.2 23 2 decreased lymphocyte cell number 5.11218903596637e-16 5.91468382649598e-14 1.08549484177892 0.765625 23.2 23 2 abnormal extraembryonic tissue morphology 5.4404044808847e-13 3.60880163898685e-11 1.08419172672276 0.764705882352941 23.2 23 2 abnormal brown adipose tissue morphology 3.38540999112047e-05 0.000475774426718202 1.08419172672276 0.764705882352941 23.2 23 2 hyperlipidemia 0.00358788825217741 0.0230915188286968 1.08419172672276 0.764705882352941 23.2 23 2 abnormal dorsal-ventral axis patterning 0.00358788825217741 0.0230915188286968 1.08419172672276 0.764705882352941 23.2 23 2 abnormal cranial suture morphology 0.00358788825217741 0.0230915188286968 1.08419172672276 0.764705882352941 23.2 23 2 abnormal embryonic-extraembryonic boundary morphology 0.00358788825217741 0.0230915188286968 1.08419172672276 0.764705882352941 23.2 23 2 abnormal ectoplacental cone morphology 0.00358788825217741 0.0230915188286968 1.08419172672276 0.764705882352941 23.2 23 2 increased brain size 0.00358788825217741 0.0230915188286968 1.08419172672276 0.764705882352941 23.2 23 2 increased circulating magnesium level 0.00358788825217741 0.0230915188286968 1.08419172672276 0.764705882352941 23.2 23 2 abnormal ductus venosus valve morphology 0.00358788825217741 0.0230915188286968 1.08419172672276 0.764705882352941 23.2 23 2 persistence of hyaloid vascular system 1.26352993775261e-05 0.000194658620858084 1.08199700662818 0.763157894736842 23.2 23 2 decreased IgM level 2.63365575129307e-12 1.57860691116663e-10 1.08161236496212 0.762886597938144 23.2 23 2 abnormal hematopoietic system physiology 0.00128304388731758 0.010131973554611 1.08022032845638 0.761904761904762 23.2 23 2 abnormal tumor vascularization 0.00128304388731758 0.010131973554611 1.08022032845638 0.761904761904762 23.2 23 2 vascular ring 0.00128304388731758 0.010131973554611 1.08022032845638 0.761904761904762 23.2 23 2 absent segment of posterior cerebral artery 0.00128304388731758 0.010131973554611 1.08022032845638 0.761904761904762 23.2 23 2 increased T cell number 3.32075130353844e-11 1.66808510438706e-09 1.07945312651855 0.761363636363636 23.2 23 2 abnormal thyroid gland morphology 0.000465779923482645 0.00422736427517823 1.07751977763524 0.76 23.2 23 2 spontaneous skin ulceration 0.000465779923482645 0.00422736427517823 1.07751977763524 0.76 23.2 23 2 abnormal preimplantation embryo development 0.000465779923482645 0.00422736427517823 1.07751977763524 0.76 23.2 23 2 decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 0.000465779923482645 0.00422736427517823 1.07751977763524 0.76 23.2 23 2 abnormal placenta morphology 4.19696013446376e-10 1.67039013351658e-08 1.07680190969544 0.759493670886076 23.2 23 2 abnormal embryonic erythropoiesis 0.000170917021576036 0.00188958262742395 1.07556420635096 0.758620689655172 23.2 23 2 increased double-positive T cell number 0.000170917021576036 0.00188958262742395 1.07556420635096 0.758620689655172 23.2 23 2 decreased brown adipose tissue amount 6.32241618505261e-05 0.000808586645774724 1.07408271295378 0.757575757575758 23.2 23 2 embryonic lethality between somite formation and embryo turning, complete penetrance 5.32050753875635e-09 1.78848141927789e-07 1.07346895140352 0.757142857142857 23.2 23 2 decreased T cell proliferation 1.97235265935773e-17 2.88601602361903e-15 1.07292154245329 0.756756756756757 23.2 23 2 pale liver 2.0303074300174e-09 7.11322497488491e-08 1.07292154245329 0.756756756756757 23.2 23 2 abnormal calcium ion homeostasis 2.35336833198785e-05 0.000347359297475555 1.07292154245329 0.756756756756757 23.2 23 2 arrested B cell differentiation 8.80348594825215e-06 0.000140827468143262 1.07198694180656 0.75609756097561 23.2 23 2 oxidative stress 4.34788123606635e-11 2.06006753804096e-09 1.07121849238591 0.755555555555556 23.2 23 2 abnormal long bone hypertrophic chondrocyte zone 1.24608501420487e-06 2.34820944911713e-05 1.07057550409516 0.755102040816326 23.2 23 2 extramedullary hematopoiesis 9.41598655481215e-13 5.92968773546715e-11 1.07002957064075 0.754716981132076 23.2 23 2 increased hepatocellular carcinoma incidence 1.78387359890946e-07 4.18621280876158e-06 1.06956025942556 0.754385964912281 23.2 23 2 perimembraneous ventricular septal defect 9.80603212875748e-09 3.06823961261437e-07 1.06847880314707 0.753623188405797 23.2 23 2 abnormal lung development 2.08751684933412e-10 8.72722380288845e-09 1.06751185400395 0.752941176470588 23.2 23 2 decreased IgA level 8.6616456726477e-07 1.70998758815168e-05 1.06334188582425 0.75 23.2 23 2 abnormal foregut morphology 0.000867106867099635 0.00717962291352004 1.06334188582425 0.75 23.2 23 2 decreased metastatic potential 0.000867106867099635 0.00717962291352004 1.06334188582425 0.75 23.2 23 2 blindness 0.000867106867099635 0.00717962291352004 1.06334188582425 0.75 23.2 23 2 increased body temperature 0.000867106867099635 0.00717962291352004 1.06334188582425 0.75 23.2 23 2 abnormal adipose tissue distribution 0.0194708627836767 0.0854211131823557 1.06334188582425 0.75 23.2 23 2 myocarditis 0.0194708627836767 0.0854211131823557 1.06334188582425 0.75 23.2 23 2 interstitial pneumonia 0.0194708627836767 0.0854211131823557 1.06334188582425 0.75 23.2 23 2 abnormal embryonic growth/weight/body size 0.0194708627836767 0.0854211131823557 1.06334188582425 0.75 23.2 23 2 abnormal tracheal ciliated epithelium morphology 0.0194708627836767 0.0854211131823557 1.06334188582425 0.75 23.2 23 2 abnormal defecation 0.0194708627836767 0.0854211131823557 1.06334188582425 0.75 23.2 23 2 hemoperitoneum 0.0194708627836767 0.0854211131823557 1.06334188582425 0.75 23.2 23 2 abnormal thymus corticomedullary boundary morphology 0.0194708627836767 0.0854211131823557 1.06334188582425 0.75 23.2 23 2 decreased mammary gland epithelial cell proliferation 0.0194708627836767 0.0854211131823557 1.06334188582425 0.75 23.2 23 2 persistent right dorsal aorta 0.0194708627836767 0.0854211131823557 1.06334188582425 0.75 23.2 23 2 abnormal colon goblet cell morphology 0.0194708627836767 0.0854211131823557 1.06334188582425 0.75 23.2 23 2 impaired wound healing 4.34908751382892e-05 0.000586360714940349 1.06334188582425 0.75 23.2 23 2 abnormal somite shape 0.0003172053510507 0.0031625182795135 1.06334188582425 0.75 23.2 23 2 hypoxia 0.0003172053510507 0.0031625182795135 1.06334188582425 0.75 23.2 23 2 abnormal brainstem morphology 0.0003172053510507 0.0031625182795135 1.06334188582425 0.75 23.2 23 2 abnormal hair texture 0.00239846022791171 0.016829816126743 1.06334188582425 0.75 23.2 23 2 decreased myocardial infarction size 0.00239846022791171 0.016829816126743 1.06334188582425 0.75 23.2 23 2 abnormal thymocyte activation 0.00239846022791171 0.016829816126743 1.06334188582425 0.75 23.2 23 2 abnormal optic stalk morphology 0.00239846022791171 0.016829816126743 1.06334188582425 0.75 23.2 23 2 abnormal sperm mitochondrial sheath morphology 0.00239846022791171 0.016829816126743 1.06334188582425 0.75 23.2 23 2 decreased mast cell number 0.00674649796712308 0.0375014831133378 1.06334188582425 0.75 23.2 23 2 intraventricular hemorrhage 0.00674649796712308 0.0375014831133378 1.06334188582425 0.75 23.2 23 2 abnormal pulmonary elastic fiber morphology 0.00674649796712308 0.0375014831133378 1.06334188582425 0.75 23.2 23 2 large intestinal inflammation 0.00674649796712308 0.0375014831133378 1.06334188582425 0.75 23.2 23 2 small pancreas 0.00674649796712308 0.0375014831133378 1.06334188582425 0.75 23.2 23 2 abnormal level of surface class II molecules 0.00674649796712308 0.0375014831133378 1.06334188582425 0.75 23.2 23 2 sepsis 0.00674649796712308 0.0375014831133378 1.06334188582425 0.75 23.2 23 2 dystonia 0.00674649796712308 0.0375014831133378 1.06334188582425 0.75 23.2 23 2 increased heart left ventricle size 0.00674649796712308 0.0375014831133378 1.06334188582425 0.75 23.2 23 2 schistocytosis 0.0587462218006189 0.19536260257893 1.06334188582425 0.75 23.2 23 2 abnormal cecum morphology 0.0587462218006189 0.19536260257893 1.06334188582425 0.75 23.2 23 2 absent mammary gland 0.0587462218006189 0.19536260257893 1.06334188582425 0.75 23.2 23 2 enlarged pituitary gland 0.0587462218006189 0.19536260257893 1.06334188582425 0.75 23.2 23 2 abnormal hypoglossal nerve morphology 0.0587462218006189 0.19536260257893 1.06334188582425 0.75 23.2 23 2 abnormal vagus ganglion morphology 0.0587462218006189 0.19536260257893 1.06334188582425 0.75 23.2 23 2 poor grooming 0.0587462218006189 0.19536260257893 1.06334188582425 0.75 23.2 23 2 coarse hair 0.0587462218006189 0.19536260257893 1.06334188582425 0.75 23.2 23 2 early eyelid opening 0.0587462218006189 0.19536260257893 1.06334188582425 0.75 23.2 23 2 abnormal cellular cholesterol metabolism 0.0587462218006189 0.19536260257893 1.06334188582425 0.75 23.2 23 2 decreased susceptibility to age related obesity 0.0587462218006189 0.19536260257893 1.06334188582425 0.75 23.2 23 2 lymph node inflammation 0.0587462218006189 0.19536260257893 1.06334188582425 0.75 23.2 23 2 tau protein deposits 0.0587462218006189 0.19536260257893 1.06334188582425 0.75 23.2 23 2 abnormal lateral ganglionic eminence morphology 0.0587462218006189 0.19536260257893 1.06334188582425 0.75 23.2 23 2 small frontal bone 0.0587462218006189 0.19536260257893 1.06334188582425 0.75 23.2 23 2 absent cochlear microphonics 0.0587462218006189 0.19536260257893 1.06334188582425 0.75 23.2 23 2 accumulation of giant lysosomes in kidney/renal tubule cells 0.0587462218006189 0.19536260257893 1.06334188582425 0.75 23.2 23 2 ocular hypertension 0.0587462218006189 0.19536260257893 1.06334188582425 0.75 23.2 23 2 abnormal ilium morphology 0.0587462218006189 0.19536260257893 1.06334188582425 0.75 23.2 23 2 stomach epithelial hyperplasia 0.0587462218006189 0.19536260257893 1.06334188582425 0.75 23.2 23 2 choroidal neovascularization 0.0587462218006189 0.19536260257893 1.06334188582425 0.75 23.2 23 2 abnormal epidermal lamellar body morphology 0.0587462218006189 0.19536260257893 1.06334188582425 0.75 23.2 23 2 enlarged inguinal lymph nodes 0.0587462218006189 0.19536260257893 1.06334188582425 0.75 23.2 23 2 abnormal sphingomyelin level 0.0587462218006189 0.19536260257893 1.06334188582425 0.75 23.2 23 2 decreased hippocampus pyramidal cell number 0.0587462218006189 0.19536260257893 1.06334188582425 0.75 23.2 23 2 abnormal cerebellum deep nucleus morphology 0.0587462218006189 0.19536260257893 1.06334188582425 0.75 23.2 23 2 abnormal hepatic vein morphology 0.0587462218006189 0.19536260257893 1.06334188582425 0.75 23.2 23 2 pulmonary artery hypoplasia 0.0587462218006189 0.19536260257893 1.06334188582425 0.75 23.2 23 2 myocardial trabeculae hypoplasia 0.0587462218006189 0.19536260257893 1.06334188582425 0.75 23.2 23 2 delayed suture closure 0.0587462218006189 0.19536260257893 1.06334188582425 0.75 23.2 23 2 abnormal bronchus epithelium morphology 0.0587462218006189 0.19536260257893 1.06334188582425 0.75 23.2 23 2 absent ureteric bud 0.0587462218006189 0.19536260257893 1.06334188582425 0.75 23.2 23 2 decreased surfactant secretion 0.0587462218006189 0.19536260257893 1.06334188582425 0.75 23.2 23 2 increased aorta wall thickness 0.0587462218006189 0.19536260257893 1.06334188582425 0.75 23.2 23 2 lethality during fetal growth through weaning, incomplete penetrance 0.0587462218006189 0.19536260257893 1.06334188582425 0.75 23.2 23 2 decreased cranium length 0.0587462218006189 0.19536260257893 1.06334188582425 0.75 23.2 23 2 small thymus medulla 0.0587462218006189 0.19536260257893 1.06334188582425 0.75 23.2 23 2 embryo cyst 0.0587462218006189 0.19536260257893 1.06334188582425 0.75 23.2 23 2 decreased white adipose tissue mass 0.0587462218006189 0.19536260257893 1.06334188582425 0.75 23.2 23 2 decreased vascular endothelial cell proliferation 0.0587462218006189 0.19536260257893 1.06334188582425 0.75 23.2 23 2 hemorrhage 1.20441660152053e-25 3.74498287035291e-23 1.06183359946138 0.748936170212766 23.2 23 2 pallor 1.9747845222951e-19 3.27485099947271e-17 1.06131647270839 0.748571428571429 23.2 23 2 decreased IgG level 8.51301301372538e-13 5.57266312411628e-11 1.0601486669479 0.747747747747748 23.2 23 2 double outlet right ventricle 2.21635708442795e-12 1.34468006036939e-10 1.06002929427962 0.747663551401869 23.2 23 2 decreased erythrocyte cell number 2.96763922461286e-17 3.88526451117079e-15 1.05656900757059 0.745222929936306 23.2 23 2 increased lung adenocarcinoma incidence 1.5837390904858e-06 2.9509745225344e-05 1.05639193885807 0.745098039215686 23.2 23 2 abnormal cell nucleus morphology 4.19629599583498e-06 7.29185811163647e-05 1.05580045400989 0.74468085106383 23.2 23 2 increased respiratory quotient 4.19629599583498e-06 7.29185811163647e-05 1.05580045400989 0.74468085106383 23.2 23 2 increased hepatocyte apoptosis 2.97491005730077e-05 0.000421657479631661 1.05425349363771 0.743589743589744 23.2 23 2 failure of heart looping 2.97491005730077e-05 0.000421657479631661 1.05425349363771 0.743589743589744 23.2 23 2 abnormal liver development 7.97087963990337e-05 0.000979138918728871 1.05321482024497 0.742857142857143 23.2 23 2 increased carcinoma incidence 7.97087963990337e-05 0.000979138918728871 1.05321482024497 0.742857142857143 23.2 23 2 increased circulating serum albumin level 7.97087963990337e-05 0.000979138918728871 1.05321482024497 0.742857142857143 23.2 23 2 decreased bone mineralization 7.97087963990337e-05 0.000979138918728871 1.05321482024497 0.742857142857143 23.2 23 2 abnormal definitive hematopoiesis 1.29263080937372e-10 5.54382610054679e-09 1.05190810210571 0.741935483870968 23.2 23 2 abnormal postnatal growth/weight/body size 0.000214750380612197 0.00228775833735692 1.05190810210571 0.741935483870968 23.2 23 2 abnormal mitochondrial ATP synthesis coupled electron transport 0.000214750380612197 0.00228775833735692 1.05190810210571 0.741935483870968 23.2 23 2 anophthalmia 3.37144641789937e-10 1.36365414057312e-08 1.05139422418577 0.741573033707865 23.2 23 2 abnormal apoptosis 1.08903469096065e-06 2.0918716554167e-05 1.05021420822148 0.740740740740741 23.2 23 2 neurodegeneration 1.08903469096065e-06 2.0918716554167e-05 1.05021420822148 0.740740740740741 23.2 23 2 abnormal cell adhesion 1.08903469096065e-06 2.0918716554167e-05 1.05021420822148 0.740740740740741 23.2 23 2 abnormal fetal cardiomyocyte proliferation 0.000582635506778696 0.00512122198979508 1.05021420822148 0.740740740740741 23.2 23 2 abnormal eye muscle morphology 0.000582635506778696 0.00512122198979508 1.05021420822148 0.740740740740741 23.2 23 2 abnormal skin appearance 0.000582635506778696 0.00512122198979508 1.05021420822148 0.740740740740741 23.2 23 2 astrocytosis 1.57225466029074e-08 4.71202827406412e-07 1.04877555862117 0.73972602739726 23.2 23 2 decreased percent body fat/body weight 1.57225466029074e-08 4.71202827406412e-07 1.04877555862117 0.73972602739726 23.2 23 2 abnormal Wolffian duct morphology 0.00159521715263283 0.0123233002086154 1.04793113385578 0.739130434782609 23.2 23 2 dilated heart 0.00159521715263283 0.0123233002086154 1.04793113385578 0.739130434782609 23.2 23 2 abnormal chondrocyte physiology 0.00159521715263283 0.0123233002086154 1.04793113385578 0.739130434782609 23.2 23 2 increased lymphocyte cell number 4.11865225901841e-08 1.09573769992602e-06 1.04793113385578 0.739130434782609 23.2 23 2 abnormal hepatocyte morphology 3.52029774005109e-12 2.0364513089249e-10 1.0473757914425 0.738738738738739 23.2 23 2 abnormal dendritic cell physiology 9.15265283207256e-12 4.94939650430011e-10 1.04677892810113 0.738317757009346 23.2 23 2 abnormal craniofacial morphology 2.38049999384132e-11 1.22092654323305e-09 1.04613570644198 0.737864077669903 23.2 23 2 decreased circulating serum albumin level 6.19385096759414e-11 2.83282111289573e-09 1.04544050727502 0.737373737373737 23.2 23 2 increased mean corpuscular hemoglobin 6.19385096759414e-11 2.83282111289573e-09 1.04544050727502 0.737373737373737 23.2 23 2 incomplete somite formation 5.40491583584648e-05 0.000703912468150163 1.04468676502031 0.736842105263158 23.2 23 2 kyphoscoliosis 0.00442191793702404 0.0272602747666599 1.04468676502031 0.736842105263158 23.2 23 2 abnormal triglyceride level 0.00442191793702404 0.0272602747666599 1.04468676502031 0.736842105263158 23.2 23 2 unresponsive to tactile stimuli 0.00442191793702404 0.0272602747666599 1.04468676502031 0.736842105263158 23.2 23 2 increased liver adenoma incidence 0.00442191793702404 0.0272602747666599 1.04468676502031 0.736842105263158 23.2 23 2 oliguria 0.00442191793702404 0.0272602747666599 1.04468676502031 0.736842105263158 23.2 23 2 increased left ventricle weight 0.00442191793702404 0.0272602747666599 1.04468676502031 0.736842105263158 23.2 23 2 decreased susceptibility to weight gain 0.00442191793702404 0.0272602747666599 1.04468676502031 0.736842105263158 23.2 23 2 enlarged kidney 1.9672279313971e-06 3.59814667599285e-05 1.04327883137473 0.735849056603774 23.2 23 2 enlarged liver sinusoidal spaces 0.000144807667237531 0.00162990530431384 1.04249204492573 0.735294117647059 23.2 23 2 lung hemorrhage 0.000144807667237531 0.00162990530431384 1.04249204492573 0.735294117647059 23.2 23 2 abnormal spleen red pulp morphology 0.000144807667237531 0.00162990530431384 1.04249204492573 0.735294117647059 23.2 23 2 abnormal craniofacial development 5.19593360450325e-06 8.73303029810935e-05 1.04164103101151 0.73469387755102 23.2 23 2 abnormal embryonic tissue morphology 2.64203052619623e-15 2.79661741868643e-13 1.04164103101151 0.73469387755102 23.2 23 2 abnormal somite development 7.44337257715449e-09 2.42646272306351e-07 1.04090851270559 0.734177215189873 23.2 23 2 absent mesoderm 5.10186448962266e-07 1.0754989760963e-05 1.03971206613926 0.733333333333333 23.2 23 2 muscular ventricular septal defect 5.10186448962266e-07 1.0754989760963e-05 1.03971206613926 0.733333333333333 23.2 23 2 disorganized myocardium 0.000390106744921151 0.00372510759305705 1.03971206613926 0.733333333333333 23.2 23 2 decreased hepatocyte number 0.0124759276148251 0.0593550206140278 1.03971206613926 0.733333333333333 23.2 23 2 no suckling reflex 0.0124759276148251 0.0593550206140278 1.03971206613926 0.733333333333333 23.2 23 2 absent egg cylinders 0.0124759276148251 0.0593550206140278 1.03971206613926 0.733333333333333 23.2 23 2 abnormal pericyte morphology 0.0124759276148251 0.0593550206140278 1.03971206613926 0.733333333333333 23.2 23 2 enlarged spleen 3.15747466532255e-28 1.20834126615229e-25 1.03872749031906 0.732638888888889 23.2 23 2 abnormal blood vessel morphology 8.42279992015676e-15 7.61880538232362e-13 1.03645278066547 0.731034482758621 23.2 23 2 thrombocytopenia 8.42279992015676e-15 7.61880538232362e-13 1.03645278066547 0.731034482758621 23.2 23 2 increased urine protein level 1.33086086252606e-08 4.03721511650437e-07 1.03607670926465 0.730769230769231 23.2 23 2 no spontaneous movement 0.00105827469375663 0.00851928252660067 1.03607670926465 0.730769230769231 23.2 23 2 pulmonary edema 0.00105827469375663 0.00851928252660067 1.03607670926465 0.730769230769231 23.2 23 2 decreased hemoglobin content 2.17923615957562e-14 1.86925860239461e-12 1.03568996917161 0.730496453900709 23.2 23 2 decreased susceptibility to hepatic steatosis 3.47929491948848e-07 7.69310765531342e-06 1.03521114810403 0.73015873015873 23.2 23 2 decreased leukocyte cell number 5.63815543161327e-14 4.52416504391549e-12 1.03488261394087 0.72992700729927 23.2 23 2 anemia 1.00708938482019e-20 1.92702680364633e-18 1.03478452080211 0.729857819905213 23.2 23 2 abnormal branching of the mammary ductal tree 9.73752930479986e-05 0.00117014995872897 1.0346029159371 0.72972972972973 23.2 23 2 thymus atrophy 9.31785129396666e-06 0.000148103227436052 1.03380461121802 0.729166666666667 23.2 23 2 increased circulating alkaline phosphatase level 4.09853734155515e-16 4.85481506529449e-14 1.03271063808445 0.728395061728395 23.2 23 2 ventricular septal defect 1.00144672899465e-13 7.6649191949975e-12 1.03206712447647 0.727941176470588 23.2 23 2 abnormal germ layer development 0.00289699734288745 0.0192939247401139 1.03111940443563 0.727272727272727 23.2 23 2 abnormal oogenesis 0.00289699734288745 0.0192939247401139 1.03111940443563 0.727272727272727 23.2 23 2 increased skin papilloma incidence 0.00289699734288745 0.0192939247401139 1.03111940443563 0.727272727272727 23.2 23 2 abnormal chorion morphology 0.00289699734288745 0.0192939247401139 1.03111940443563 0.727272727272727 23.2 23 2 increased myocardial infarction size 0.00289699734288745 0.0192939247401139 1.03111940443563 0.727272727272727 23.2 23 2 abnormal mesenteric lymph node morphology 0.00289699734288745 0.0192939247401139 1.03111940443563 0.727272727272727 23.2 23 2 decreased susceptibility to viral infection induced morbidity/mortality 0.00289699734288745 0.0192939247401139 1.03111940443563 0.727272727272727 23.2 23 2 pulmonary vascular congestion 0.00289699734288745 0.0192939247401139 1.03111940443563 0.727272727272727 23.2 23 2 increased circulating creatine kinase level 0.00289699734288745 0.0192939247401139 1.03111940443563 0.727272727272727 23.2 23 2 rough coat 0.00289699734288745 0.0192939247401139 1.03111940443563 0.727272727272727 23.2 23 2 embryonic lethality before implantation, incomplete penetrance 0.00289699734288745 0.0192939247401139 1.03111940443563 0.727272727272727 23.2 23 2 impaired humoral immune response 0.00289699734288745 0.0192939247401139 1.03111940443563 0.727272727272727 23.2 23 2 premature suture closure 0.036172406802653 0.133698160358989 1.03111940443563 0.727272727272727 23.2 23 2 abnormal sphenoid bone morphology 0.036172406802653 0.133698160358989 1.03111940443563 0.727272727272727 23.2 23 2 abnormal thrombopoiesis 0.036172406802653 0.133698160358989 1.03111940443563 0.727272727272727 23.2 23 2 abnormal eye distance/ position 0.036172406802653 0.133698160358989 1.03111940443563 0.727272727272727 23.2 23 2 abnormal food preference 0.036172406802653 0.133698160358989 1.03111940443563 0.727272727272727 23.2 23 2 abnormal hemoglobin 0.036172406802653 0.133698160358989 1.03111940443563 0.727272727272727 23.2 23 2 impaired myelopoiesis 0.036172406802653 0.133698160358989 1.03111940443563 0.727272727272727 23.2 23 2 vasculitis 0.036172406802653 0.133698160358989 1.03111940443563 0.727272727272727 23.2 23 2 retinal detachment 0.036172406802653 0.133698160358989 1.03111940443563 0.727272727272727 23.2 23 2 loss of cortex neurons 0.036172406802653 0.133698160358989 1.03111940443563 0.727272727272727 23.2 23 2 pulmonary hypertension 0.036172406802653 0.133698160358989 1.03111940443563 0.727272727272727 23.2 23 2 abnormal radial glial cell morphology 0.036172406802653 0.133698160358989 1.03111940443563 0.727272727272727 23.2 23 2 pathological neovascularization 0.036172406802653 0.133698160358989 1.03111940443563 0.727272727272727 23.2 23 2 abnormal coronal suture morphology 0.036172406802653 0.133698160358989 1.03111940443563 0.727272727272727 23.2 23 2 abnormal Bruch membrane morphology 0.036172406802653 0.133698160358989 1.03111940443563 0.727272727272727 23.2 23 2 increased glycogen level 0.036172406802653 0.133698160358989 1.03111940443563 0.727272727272727 23.2 23 2 aberrant origin of the right subclavian artery 0.036172406802653 0.133698160358989 1.03111940443563 0.727272727272727 23.2 23 2 common atrioventricular valve 0.036172406802653 0.133698160358989 1.03111940443563 0.727272727272727 23.2 23 2 decreased core body temperature 0.036172406802653 0.133698160358989 1.03111940443563 0.727272727272727 23.2 23 2 decreased embryonic cilium length 0.036172406802653 0.133698160358989 1.03111940443563 0.727272727272727 23.2 23 2 abnormal embryo turning 2.39507683305312e-06 4.33291172525065e-05 1.03111940443563 0.727272727272727 23.2 23 2 abnormal aorta morphology 0.000260621647469928 0.0027068741047242 1.03111940443563 0.727272727272727 23.2 23 2 abnormal T cell subpopulation ratio 0.000260621647469928 0.0027068741047242 1.03111940443563 0.727272727272727 23.2 23 2 kyphosis 7.0597289107464e-15 6.62682100584214e-13 1.03026013826527 0.726666666666667 23.2 23 2 increased B cell number 6.53360063266006e-12 3.571941005218e-10 1.0300177811403 0.726495726495726 23.2 23 2 embryonic lethality during organogenesis, incomplete penetrance 5.97119075931237e-22 1.29159452293822e-19 1.02943823149362 0.726086956521739 23.2 23 2 increased spleen weight 1.6902088099348e-11 8.94552003130385e-10 1.0288381668152 0.725663716814159 23.2 23 2 microcephaly 1.6092816310217e-07 3.84912313189084e-06 1.02738346456449 0.72463768115942 23.2 23 2 lordosis 0.000701212215921699 0.00606701004210514 1.0266749242441 0.724137931034483 23.2 23 2 thin ventricular wall 2.88008775757516e-09 9.81399766707975e-08 1.02395885301594 0.722222222222222 23.2 23 2 abnormal long bone epiphyseal plate proliferative zone 4.25053035653181e-06 7.29185811163647e-05 1.02395885301594 0.722222222222222 23.2 23 2 axon degeneration 4.25053035653181e-06 7.29185811163647e-05 1.02395885301594 0.722222222222222 23.2 23 2 heart right ventricle hypertrophy 0.000173875391676969 0.0019137833486569 1.02395885301594 0.722222222222222 23.2 23 2 cortical renal glomerulopathies 0.00802808846508327 0.0434600001238186 1.02395885301594 0.722222222222222 23.2 23 2 abnormal thymus medulla morphology 0.00802808846508327 0.0434600001238186 1.02395885301594 0.722222222222222 23.2 23 2 abnormal redox activity 0.00802808846508327 0.0434600001238186 1.02395885301594 0.722222222222222 23.2 23 2 decreased lactate dehydrogenase level 0.00802808846508327 0.0434600001238186 1.02395885301594 0.722222222222222 23.2 23 2 decreased pulmonary respiratory rate 0.00802808846508327 0.0434600001238186 1.02395885301594 0.722222222222222 23.2 23 2 increased gastrointestinal tumor incidence 0.00802808846508327 0.0434600001238186 1.02395885301594 0.722222222222222 23.2 23 2 primary atelectasis 0.00802808846508327 0.0434600001238186 1.02395885301594 0.722222222222222 23.2 23 2 abnormal aerobic respiration 0.00802808846508327 0.0434600001238186 1.02395885301594 0.722222222222222 23.2 23 2 increased adipocyte glucose uptake 0.00802808846508327 0.0434600001238186 1.02395885301594 0.722222222222222 23.2 23 2 abnormal neural tube morphology 1.54984122630089e-15 1.71343557796599e-13 1.02395885301594 0.722222222222222 23.2 23 2 abnormal heart development 3.99057593918918e-15 3.97062305949324e-13 1.02296181421067 0.721518987341772 23.2 23 2 abnormal response to infection 2.85049020226262e-08 7.92245181913773e-07 1.02296181421067 0.721518987341772 23.2 23 2 abnormal myocardium layer morphology 2.85049020226262e-08 7.92245181913773e-07 1.02296181421067 0.721518987341772 23.2 23 2 increased double-negative T cell number 1.09631640340245e-06 2.09775927189507e-05 1.02266760603862 0.721311475409836 23.2 23 2 increased oxygen consumption 7.46228736942145e-09 2.42646272306351e-07 1.02212708404811 0.720930232558139 23.2 23 2 impaired macrophage phagocytosis 4.38005196874315e-05 0.000588939420121545 1.02212708404811 0.720930232558139 23.2 23 2 pericardial edema 2.84261960983877e-07 6.37028493646301e-06 1.02164220402722 0.720588235294118 23.2 23 2 increased monocyte cell number 5.14917587192369e-10 1.97054999714003e-08 1.02080821039128 0.72 23.2 23 2 abnormal neurocranium morphology 7.4014859464671e-08 1.84653441401874e-06 1.02080821039128 0.72 23.2 23 2 abnormal interventricular septum morphology 1.11565612040916e-05 0.000173993391819298 1.02080821039128 0.72 23.2 23 2 abnormal keratinocyte physiology 0.00189909043640049 0.0141225335143385 1.02080821039128 0.72 23.2 23 2 diaphragmatic hernia 0.00189909043640049 0.0141225335143385 1.02080821039128 0.72 23.2 23 2 increased cellular sensitivity to ionizing radiation 0.00189909043640049 0.0141225335143385 1.02080821039128 0.72 23.2 23 2 abnormal cochlear outer hair cell morphology 0.00189909043640049 0.0141225335143385 1.02080821039128 0.72 23.2 23 2 decreased birth body size 3.57710206538337e-11 1.74471399757669e-09 1.01981327061507 0.719298245614035 23.2 23 2 increased sacral vertebrae number 7.40328197876172e-07 1.49114687628905e-05 1.0190359739149 0.71875 23.2 23 2 scoliosis 0.000464403985046181 0.00422736427517823 1.0190359739149 0.71875 23.2 23 2 failure of primitive streak formation 0.000464403985046181 0.00422736427517823 1.0190359739149 0.71875 23.2 23 2 abnormal allantois morphology 2.93271460789752e-05 0.000421066433402079 1.01710962991884 0.717391304347826 23.2 23 2 abnormal myelin sheath morphology 2.93271460789752e-05 0.000421066433402079 1.01710962991884 0.717391304347826 23.2 23 2 atrial septal defect 2.93271460789752e-05 0.000421066433402079 1.01710962991884 0.717391304347826 23.2 23 2 abnormal embryo size 6.26352406871417e-11 2.83282111289573e-09 1.01629135990282 0.716814159292035 23.2 23 2 increased granulocyte number 1.29882112832651e-07 3.15201712849969e-06 1.01544360267901 0.716216216216216 23.2 23 2 abnormal cytokine secretion 3.73876673522163e-14 3.13178342235595e-12 1.01270655792785 0.714285714285714 23.2 23 2 disheveled coat 7.72221990148467e-05 0.000962858245861811 1.01270655792785 0.714285714285714 23.2 23 2 abnormal cytotoxic T cell physiology 7.72221990148467e-05 0.000962858245861811 1.01270655792785 0.714285714285714 23.2 23 2 abnormal artery morphology 0.000307554844333774 0.00308484949709783 1.01270655792785 0.714285714285714 23.2 23 2 abnormal embryonic epiblast morphology 0.000307554844333774 0.00308484949709783 1.01270655792785 0.714285714285714 23.2 23 2 shortened head 0.00124621089609869 0.00990399234519323 1.01270655792785 0.714285714285714 23.2 23 2 failure of blastocyst to hatch from the zona pellucida 0.00124621089609869 0.00990399234519323 1.01270655792785 0.714285714285714 23.2 23 2 abnormal salivary gland morphology 0.00518700107939704 0.0301464139836452 1.01270655792785 0.714285714285714 23.2 23 2 liver degeneration 0.00518700107939704 0.0301464139836452 1.01270655792785 0.714285714285714 23.2 23 2 left pulmonary isomerism 0.00518700107939704 0.0301464139836452 1.01270655792785 0.714285714285714 23.2 23 2 abnormal erythrocyte physiology 0.00518700107939704 0.0301464139836452 1.01270655792785 0.714285714285714 23.2 23 2 abnormal clavicle morphology 0.00518700107939704 0.0301464139836452 1.01270655792785 0.714285714285714 23.2 23 2 embryonic lethality at implantation, complete penetrance 0.00518700107939704 0.0301464139836452 1.01270655792785 0.714285714285714 23.2 23 2 increased muscle cell glucose uptake 0.00518700107939704 0.0301464139836452 1.01270655792785 0.714285714285714 23.2 23 2 midline facial cleft 0.0226372167723424 0.0949579708620601 1.01270655792785 0.714285714285714 23.2 23 2 irregularly shaped pupil 0.0226372167723424 0.0949579708620601 1.01270655792785 0.714285714285714 23.2 23 2 abnormal adrenal gland secretion 0.0226372167723424 0.0949579708620601 1.01270655792785 0.714285714285714 23.2 23 2 absent olfactory bulb 0.0226372167723424 0.0949579708620601 1.01270655792785 0.714285714285714 23.2 23 2 abnormal vascular endothelial cell migration 0.0226372167723424 0.0949579708620601 1.01270655792785 0.714285714285714 23.2 23 2 abnormal viscerocranium morphology 0.0226372167723424 0.0949579708620601 1.01270655792785 0.714285714285714 23.2 23 2 abnormal glucose tolerance 0.0226372167723424 0.0949579708620601 1.01270655792785 0.714285714285714 23.2 23 2 decreased cornea thickness 0.0226372167723424 0.0949579708620601 1.01270655792785 0.714285714285714 23.2 23 2 increased stomach tumor incidence 0.0226372167723424 0.0949579708620601 1.01270655792785 0.714285714285714 23.2 23 2 pulmonary alveolar hemorrhage 0.0226372167723424 0.0949579708620601 1.01270655792785 0.714285714285714 23.2 23 2 decreased compact bone area 0.0226372167723424 0.0949579708620601 1.01270655792785 0.714285714285714 23.2 23 2 testis degeneration 0.0226372167723424 0.0949579708620601 1.01270655792785 0.714285714285714 23.2 23 2 multiple persisting craniopharyngeal ducts 0.0226372167723424 0.0949579708620601 1.01270655792785 0.714285714285714 23.2 23 2 abnormal vitelline vein topology 0.0226372167723424 0.0949579708620601 1.01270655792785 0.714285714285714 23.2 23 2 cochlear degeneration 0.1099957953613 0.301675556233449 1.01270655792785 0.714285714285714 23.2 23 2 failure of atrioventricular cushion closure 0.1099957953613 0.301675556233449 1.01270655792785 0.714285714285714 23.2 23 2 maxilla hypoplasia 0.1099957953613 0.301675556233449 1.01270655792785 0.714285714285714 23.2 23 2 decreased Schwann cell number 0.1099957953613 0.301675556233449 1.01270655792785 0.714285714285714 23.2 23 2 skin photosensitivity 0.1099957953613 0.301675556233449 1.01270655792785 0.714285714285714 23.2 23 2 abnormal lacrimal gland morphology 0.1099957953613 0.301675556233449 1.01270655792785 0.714285714285714 23.2 23 2 abnormal axial mesoderm 0.1099957953613 0.301675556233449 1.01270655792785 0.714285714285714 23.2 23 2 absent amniotic folds 0.1099957953613 0.301675556233449 1.01270655792785 0.714285714285714 23.2 23 2 detached tectorial membrane 0.1099957953613 0.301675556233449 1.01270655792785 0.714285714285714 23.2 23 2 abnormal sinus venosus morphology 0.1099957953613 0.301675556233449 1.01270655792785 0.714285714285714 23.2 23 2 increased cell nucleus count 0.1099957953613 0.301675556233449 1.01270655792785 0.714285714285714 23.2 23 2 renal necrosis 0.1099957953613 0.301675556233449 1.01270655792785 0.714285714285714 23.2 23 2 absent deltoid tuberosity 0.1099957953613 0.301675556233449 1.01270655792785 0.714285714285714 23.2 23 2 abnormal cochlear nerve compound action potential 0.1099957953613 0.301675556233449 1.01270655792785 0.714285714285714 23.2 23 2 increased prostate gland weight 0.1099957953613 0.301675556233449 1.01270655792785 0.714285714285714 23.2 23 2 abnormal MHC II cell surface expression on macrophages 0.1099957953613 0.301675556233449 1.01270655792785 0.714285714285714 23.2 23 2 increased adrenocorticotropin level 0.1099957953613 0.301675556233449 1.01270655792785 0.714285714285714 23.2 23 2 abnormal thyroid hormone level 0.1099957953613 0.301675556233449 1.01270655792785 0.714285714285714 23.2 23 2 increased tumor latency 0.1099957953613 0.301675556233449 1.01270655792785 0.714285714285714 23.2 23 2 abnormal cerebellum white matter morphology 0.1099957953613 0.301675556233449 1.01270655792785 0.714285714285714 23.2 23 2 decreased DN4 thymocyte number 0.1099957953613 0.301675556233449 1.01270655792785 0.714285714285714 23.2 23 2 focal dorsal hair loss 0.1099957953613 0.301675556233449 1.01270655792785 0.714285714285714 23.2 23 2 abnormal retina inner limiting membrane morphology 0.1099957953613 0.301675556233449 1.01270655792785 0.714285714285714 23.2 23 2 decreased skeletal muscle glycogen level 0.1099957953613 0.301675556233449 1.01270655792785 0.714285714285714 23.2 23 2 heart right ventricle outflow tract stenosis 0.1099957953613 0.301675556233449 1.01270655792785 0.714285714285714 23.2 23 2 heart block 0.1099957953613 0.301675556233449 1.01270655792785 0.714285714285714 23.2 23 2 altered tumor pathology 0.1099957953613 0.301675556233449 1.01270655792785 0.714285714285714 23.2 23 2 abnormal impulsive behavior control 0.1099957953613 0.301675556233449 1.01270655792785 0.714285714285714 23.2 23 2 small lung saccule 0.1099957953613 0.301675556233449 1.01270655792785 0.714285714285714 23.2 23 2 abnormal brain ependyma motile cilium physiology 0.1099957953613 0.301675556233449 1.01270655792785 0.714285714285714 23.2 23 2 embryonic lethality at implantation, incomplete penetrance 0.1099957953613 0.301675556233449 1.01270655792785 0.714285714285714 23.2 23 2 parturition failure 0.1099957953613 0.301675556233449 1.01270655792785 0.714285714285714 23.2 23 2 ductus venosus stenosis 0.1099957953613 0.301675556233449 1.01270655792785 0.714285714285714 23.2 23 2 absent connection between subcutaneous lymph vessels and lymph sac 0.1099957953613 0.301675556233449 1.01270655792785 0.714285714285714 23.2 23 2 decreased collagen level 0.1099957953613 0.301675556233449 1.01270655792785 0.714285714285714 23.2 23 2 increased insulin sensitivity 3.61730206234086e-13 2.53465883945715e-11 1.01129018511956 0.713286713286713 23.2 23 2 decreased bone marrow cell number 2.26773246738943e-07 5.14192780275181e-06 1.00993201941298 0.712328767123288 23.2 23 2 abnormal myocardial fiber morphology 2.74265138175096e-09 9.41013146497313e-08 1.00853044841063 0.711340206185567 23.2 23 2 abnormal ectoderm development 5.14367089430571e-05 0.000671647314938869 1.00820563989262 0.711111111111111 23.2 23 2 increased leukocyte cell number 4.25430197276437e-13 2.86015571817605e-11 1.00711921140135 0.710344827586207 23.2 23 2 thymus hypoplasia 1.60658809781538e-12 9.99096973328942e-11 1.0068357952732 0.710144927536232 23.2 23 2 abnormal capillary morphology 0.000818755635454149 0.00699881320684604 1.00617296723154 0.709677419354839 23.2 23 2 abnormal platelet physiology 8.77319832001115e-06 0.000140827468143262 1.00534141932474 0.709090909090909 23.2 23 2 abnormal nervous system morphology 1.02722147544367e-07 2.52991427739221e-06 1.00501511571574 0.708860759493671 23.2 23 2 hydrops fetalis 3.93893410809741e-07 8.6326859858082e-06 1.00426733661179 0.708333333333333 23.2 23 2 abnormal intestinal epithelium morphology 3.42578533744594e-05 0.000480092452219536 1.00426733661179 0.708333333333333 23.2 23 2 abnormal tumor morphology 0.00336348498892771 0.0219309801047384 1.00426733661179 0.708333333333333 23.2 23 2 decreased rib number 1.80986381181823e-08 5.35956694273552e-07 1.00360357763187 0.707865168539326 23.2 23 2 abnormal developmental patterning 6.90882015472644e-08 1.77172063246206e-06 1.00282649394807 0.707317073170732 23.2 23 2 abnormal mammary gland development 0.000134989116953687 0.00152977416137721 1.00282649394807 0.707317073170732 23.2 23 2 Leydig cell hyperplasia 0.000134989116953687 0.00152977416137721 1.00282649394807 0.707317073170732 23.2 23 2 hemopericardium 0.000134989116953687 0.00152977416137721 1.00282649394807 0.707317073170732 23.2 23 2 abnormal spleen morphology 4.24849061307002e-15 4.14436094118104e-13 1.00223028319067 0.706896551724138 23.2 23 2 preweaning lethality, incomplete penetrance 1.86604554359999e-33 8.43961507219084e-31 1.00181191525088 0.706601466992665 23.2 23 2 abnormal lung morphology 1.0129918573098e-10 4.4996736518895e-09 1.0007923631287 0.705882352941177 23.2 23 2 abnormal bone marrow cavity morphology 0.0143271612829927 0.0664283572999893 1.0007923631287 0.705882352941177 23.2 23 2 abnormal interatrial septum morphology 0.0143271612829927 0.0664283572999893 1.0007923631287 0.705882352941177 23.2 23 2 abnormal vagus nerve morphology 0.0143271612829927 0.0664283572999893 1.0007923631287 0.705882352941177 23.2 23 2 enhanced behavioral response to cocaine 0.0143271612829927 0.0664283572999893 1.0007923631287 0.705882352941177 23.2 23 2 delayed heart development 0.0143271612829927 0.0664283572999893 1.0007923631287 0.705882352941177 23.2 23 2 increased inflammatory response 8.20042413128369e-09 2.59854204160104e-07 0.99991447509087 0.705263157894737 23.2 23 2 abnormal heart ventricle morphology 1.77518555706056e-07 4.18556784188451e-06 0.999723140518522 0.705128205128205 23.2 23 2 abnormal eye morphology 3.23172570174323e-12 1.91402801978245e-10 0.999592372285622 0.705035971223022 23.2 23 2 spleen hypoplasia 1.45352960329079e-09 5.16522126883693e-08 0.999203803822149 0.704761904761905 23.2 23 2 osteoporosis 8.94836869886313e-05 0.00108316628410813 0.998896923047019 0.704545454545455 23.2 23 2 polydactyly 5.51714010871139e-09 1.83264643253935e-07 0.998239321386027 0.704081632653061 23.2 23 2 abnormal chondrocyte morphology 1.51976299008072e-05 0.000230512831574744 0.997703497810404 0.703703703703704 23.2 23 2 increased cell proliferation 1.51976299008072e-05 0.000230512831574744 0.997703497810404 0.703703703703704 23.2 23 2 decreased tumor growth/size 1.51976299008072e-05 0.000230512831574744 0.997703497810404 0.703703703703704 23.2 23 2 thin epidermis 0.00218791776282921 0.0157596110454728 0.997703497810404 0.703703703703704 23.2 23 2 decreased bone ossification 0.00218791776282921 0.0157596110454728 0.997703497810404 0.703703703703704 23.2 23 2 increased neuron apoptosis 1.19123255819364e-07 2.90508920441832e-06 0.997703497810404 0.703703703703704 23.2 23 2 small spleen 2.09769815962243e-08 6.10295224802431e-07 0.997126457036656 0.703296703296703 23.2 23 2 decreased caudal vertebrae number 2.61863941864413e-06 4.65276110991234e-05 0.996883017960231 0.703125 23.2 23 2 abnormal vocalization 0.000354693806618174 0.00343307721386267 0.996284289420915 0.702702702702703 23.2 23 2 abnormal respiratory electron transport chain 0.000354693806618174 0.00343307721386267 0.996284289420915 0.702702702702703 23.2 23 2 cataract 1.17272581022722e-10 5.07331383120035e-09 0.995967606557145 0.702479338842975 23.2 23 2 decreased T cell number 1.19887154561597e-13 9.0369483930901e-12 0.995094269963891 0.701863354037267 23.2 23 2 absent vitelline blood vessels 1.01241504539504e-05 0.000159391292748112 0.994939776209821 0.701754385964912 23.2 23 2 increased macrophage cell number 1.01241504539504e-05 0.000159391292748112 0.994939776209821 0.701754385964912 23.2 23 2 short stride length 3.93768422492033e-05 0.000542658698586666 0.992452426769297 0.7 23.2 23 2 testicular atrophy 3.93768422492033e-05 0.000542658698586666 0.992452426769297 0.7 23.2 23 2 salivary gland inflammation 0.00142712498158964 0.0110936668490757 0.992452426769297 0.7 23.2 23 2 small gonad 0.00914331925828617 0.0481864547775145 0.992452426769297 0.7 23.2 23 2 abnormal trachea morphology 0.00914331925828617 0.0481864547775145 0.992452426769297 0.7 23.2 23 2 abnormal physiological neovascularization 0.00914331925828617 0.0481864547775145 0.992452426769297 0.7 23.2 23 2 kidney atrophy 0.00914331925828617 0.0481864547775145 0.992452426769297 0.7 23.2 23 2 abnormal neuron proliferation 0.00914331925828617 0.0481864547775145 0.992452426769297 0.7 23.2 23 2 enlarged testis 0.0655454017886795 0.214254159816533 0.992452426769297 0.7 23.2 23 2 abnormal epidermis suprabasal layer morphology 0.0655454017886795 0.214254159816533 0.992452426769297 0.7 23.2 23 2 abnormal mammary gland physiology 0.0655454017886795 0.214254159816533 0.992452426769297 0.7 23.2 23 2 impaired basement membrane formation 0.0655454017886795 0.214254159816533 0.992452426769297 0.7 23.2 23 2 cochlear ganglion hypoplasia 0.0655454017886795 0.214254159816533 0.992452426769297 0.7 23.2 23 2 absent seminal vesicle 0.0655454017886795 0.214254159816533 0.992452426769297 0.7 23.2 23 2 increased atrioventricular cushion size 0.0655454017886795 0.214254159816533 0.992452426769297 0.7 23.2 23 2 abnormal plasma membrane morphology 0.0655454017886795 0.214254159816533 0.992452426769297 0.7 23.2 23 2 abnormal embryonic erythrocyte morphology 0.0655454017886795 0.214254159816533 0.992452426769297 0.7 23.2 23 2 abnormal deltoid tuberosity morphology 0.0655454017886795 0.214254159816533 0.992452426769297 0.7 23.2 23 2 vascular smooth muscle hyperplasia 0.0655454017886795 0.214254159816533 0.992452426769297 0.7 23.2 23 2 protruding tongue 0.0655454017886795 0.214254159816533 0.992452426769297 0.7 23.2 23 2 abnormal cerebellar granule cell migration 0.0655454017886795 0.214254159816533 0.992452426769297 0.7 23.2 23 2 increased circulating fructosamine level 0.0655454017886795 0.214254159816533 0.992452426769297 0.7 23.2 23 2 increased T-helper 17 cell number 0.0655454017886795 0.214254159816533 0.992452426769297 0.7 23.2 23 2 abnormal heart and great artery attachment 0.0655454017886795 0.214254159816533 0.992452426769297 0.7 23.2 23 2 common ventricle 0.0655454017886795 0.214254159816533 0.992452426769297 0.7 23.2 23 2 thick aortic valve 0.0655454017886795 0.214254159816533 0.992452426769297 0.7 23.2 23 2 fusion of atlas and odontoid process 0.0655454017886795 0.214254159816533 0.992452426769297 0.7 23.2 23 2 abnormal circadian temperature homeostasis 0.0655454017886795 0.214254159816533 0.992452426769297 0.7 23.2 23 2 perinatal lethality, complete penetrance 2.56963200096145e-17 3.45511329859006e-15 0.991786798045776 0.699530516431925 23.2 23 2 seminiferous tubule degeneration 7.81308336610233e-07 1.56104778097828e-05 0.990510249808887 0.698630136986301 23.2 23 2 lung inflammation 1.61964651387559e-11 8.6642380715388e-10 0.990367442679445 0.698529411764706 23.2 23 2 gliosis 4.49519228254163e-06 7.65876082385089e-05 0.990201967751679 0.698412698412698 23.2 23 2 edema 4.21369317775612e-14 3.43657763267815e-12 0.989155242627206 0.697674418604651 23.2 23 2 abnormal left-right axis patterning 0.000154349151308883 0.00172171979318765 0.989155242627206 0.697674418604651 23.2 23 2 delayed endochondral bone ossification 0.000154349151308883 0.00172171979318765 0.989155242627206 0.697674418604651 23.2 23 2 enlarged pericardium 0.000933103361471558 0.00767304003854711 0.988156095917481 0.696969696969697 23.2 23 2 abnormal brain morphology 3.99055174276841e-13 2.75736040559345e-11 0.98628812598191 0.695652173913043 23.2 23 2 abnormal pulmonary artery morphology 0.00587249492061235 0.0333512125913772 0.98628812598191 0.695652173913043 23.2 23 2 abnormal postnatal growth 0.00587249492061235 0.0333512125913772 0.98628812598191 0.695652173913043 23.2 23 2 decreased effector memory CD8-positive, alpha-beta T cell number 0.00587249492061235 0.0333512125913772 0.98628812598191 0.695652173913043 23.2 23 2 abnormal vertebral artery topology 0.00587249492061235 0.0333512125913772 0.98628812598191 0.695652173913043 23.2 23 2 reduced long term depression 0.000611371782190146 0.00535488488802108 0.984575820207635 0.694444444444444 23.2 23 2 prenatal lethality, incomplete penetrance 3.18680972037626e-23 7.54970398041518e-21 0.984057622407526 0.694078947368421 23.2 23 2 decreased circulating creatinine level 6.74309911832834e-05 0.000854624278097412 0.983772084844201 0.693877551020408 23.2 23 2 prenatal lethality 7.66780518779274e-06 0.000124664479768853 0.983305399794464 0.693548387096774 23.2 23 2 delayed bone ossification 8.8833199998236e-07 1.74681885372025e-05 0.983000498895303 0.693333333333333 23.2 23 2 abnormal T cell differentiation 1.23263209157936e-08 3.76217463534191e-07 0.982626165118115 0.693069306930693 23.2 23 2 thick skin 0.00379092585734916 0.0238732356206482 0.981546356145458 0.692307692307692 23.2 23 2 abnormal Mullerian duct morphology 0.00379092585734916 0.0238732356206482 0.981546356145458 0.692307692307692 23.2 23 2 abnormal nerve conduction 0.00379092585734916 0.0238732356206482 0.981546356145458 0.692307692307692 23.2 23 2 absent common myeloid progenitor cells 0.040189701405236 0.146801589200476 0.981546356145458 0.692307692307692 23.2 23 2 short hair 0.040189701405236 0.146801589200476 0.981546356145458 0.692307692307692 23.2 23 2 pup cannibalization 0.040189701405236 0.146801589200476 0.981546356145458 0.692307692307692 23.2 23 2 increased pituitary adenoma incidence 0.040189701405236 0.146801589200476 0.981546356145458 0.692307692307692 23.2 23 2 abnormal bile duct development 0.040189701405236 0.146801589200476 0.981546356145458 0.692307692307692 23.2 23 2 abnormal coping response 0.040189701405236 0.146801589200476 0.981546356145458 0.692307692307692 23.2 23 2 abnormal soleus morphology 0.040189701405236 0.146801589200476 0.981546356145458 0.692307692307692 23.2 23 2 axonal dystrophy 0.040189701405236 0.146801589200476 0.981546356145458 0.692307692307692 23.2 23 2 tracheoesophageal fistula 0.040189701405236 0.146801589200476 0.981546356145458 0.692307692307692 23.2 23 2 small otic vesicle 0.040189701405236 0.146801589200476 0.981546356145458 0.692307692307692 23.2 23 2 increased cochlear inner hair cell number 0.040189701405236 0.146801589200476 0.981546356145458 0.692307692307692 23.2 23 2 increased prostaglandin level 0.040189701405236 0.146801589200476 0.981546356145458 0.692307692307692 23.2 23 2 abnormal aorta tunica media morphology 0.040189701405236 0.146801589200476 0.981546356145458 0.692307692307692 23.2 23 2 abnormal hair follicle inner root sheath morphology 0.040189701405236 0.146801589200476 0.981546356145458 0.692307692307692 23.2 23 2 abnormal leukocyte adhesion 0.000401310430510601 0.00380289407960046 0.981546356145458 0.692307692307692 23.2 23 2 increased autoantibody level 0.000401310430510601 0.00380289407960046 0.981546356145458 0.692307692307692 23.2 23 2 decreased trabecular bone volume 0.000401310430510601 0.00380289407960046 0.981546356145458 0.692307692307692 23.2 23 2 infertility 5.52556713328446e-09 1.83264643253935e-07 0.980527097208651 0.691588785046729 23.2 23 2 decreased mean corpuscular hemoglobin 3.39237635408347e-06 5.96362980974038e-05 0.979942522230188 0.691176470588235 23.2 23 2 abnormal head morphology 2.95581240225863e-05 0.000421351481410794 0.979563434213851 0.690909090909091 23.2 23 2 abnormal rostral-caudal axis patterning 2.95581240225863e-05 0.000421351481410794 0.979563434213851 0.690909090909091 23.2 23 2 prenatal lethality, complete penetrance 7.08469736578302e-21 1.40985477579082e-18 0.979192527953263 0.690647482014389 23.2 23 2 abnormal spleen white pulp morphology 0.000263853780048022 0.00272735209871154 0.978949672663592 0.69047619047619 23.2 23 2 spina bifida 0.000263853780048022 0.00272735209871154 0.978949672663592 0.69047619047619 23.2 23 2 glomerulosclerosis 1.95914302560998e-05 0.000290947359773423 0.977785642137238 0.689655172413793 23.2 23 2 abnormal parietal bone morphology 0.00245731907426977 0.017122076182762 0.977785642137238 0.689655172413793 23.2 23 2 abnormal outer ear morphology 0.00245731907426977 0.017122076182762 0.977785642137238 0.689655172413793 23.2 23 2 decreased bone strength 0.00245731907426977 0.017122076182762 0.977785642137238 0.689655172413793 23.2 23 2 blood in lymph vessels 0.00245731907426977 0.017122076182762 0.977785642137238 0.689655172413793 23.2 23 2 abnormal intestine morphology 1.50311284988317e-06 2.81127309329652e-05 0.977124976162821 0.689189189189189 23.2 23 2 small placenta 0.000173730566946688 0.0019137833486569 0.976699213645974 0.688888888888889 23.2 23 2 abnormal heart morphology 2.51559355429258e-17 3.45511329859006e-15 0.975880864912295 0.688311688311688 23.2 23 2 oligodactyly 0.000114538837544464 0.00134790881631976 0.974730062005559 0.6875 23.2 23 2 abnormal lymph node morphology 0.000114538837544464 0.00134790881631976 0.974730062005559 0.6875 23.2 23 2 curly tail 0.000114538837544464 0.00134790881631976 0.974730062005559 0.6875 23.2 23 2 neonatal lethality 0.00159832926635169 0.0123281986048057 0.974730062005559 0.6875 23.2 23 2 poor circulation 0.0250806728397698 0.104240891710823 0.974730062005559 0.6875 23.2 23 2 abnormal olfaction 0.0250806728397698 0.104240891710823 0.974730062005559 0.6875 23.2 23 2 decreased aggression towards mice 0.0250806728397698 0.104240891710823 0.974730062005559 0.6875 23.2 23 2 abnormal molar crown morphology 0.0250806728397698 0.104240891710823 0.974730062005559 0.6875 23.2 23 2 increased thymus weight 0.0250806728397698 0.104240891710823 0.974730062005559 0.6875 23.2 23 2 loose skin 0.0250806728397698 0.104240891710823 0.974730062005559 0.6875 23.2 23 2 kidney degeneration 0.0250806728397698 0.104240891710823 0.974730062005559 0.6875 23.2 23 2 impaired somite development 0.0250806728397698 0.104240891710823 0.974730062005559 0.6875 23.2 23 2 decreased liver cholesterol level 0.0250806728397698 0.104240891710823 0.974730062005559 0.6875 23.2 23 2 dilated respiratory conducting tubes 0.0250806728397698 0.104240891710823 0.974730062005559 0.6875 23.2 23 2 abnormal behavior 2.25464407373923e-20 4.00601938101881e-18 0.974092566870173 0.68705035971223 23.2 23 2 internal hemorrhage 5.72640128578818e-06 9.59220417400545e-05 0.973407497470952 0.686567164179104 23.2 23 2 holoprosencephaly 0.00104261961245076 0.00842050742198462 0.972198295610739 0.685714285714286 23.2 23 2 increased red blood cell distribution width 0.00104261961245076 0.00842050742198462 0.972198295610739 0.685714285714286 23.2 23 2 impaired adaptive thermogenesis 0.00104261961245076 0.00842050742198462 0.972198295610739 0.685714285714286 23.2 23 2 short snout 1.04441726915845e-08 3.24748494628955e-07 0.971448142604867 0.685185185185185 23.2 23 2 abnormal small intestine morphology 4.99546640514907e-05 0.000659216057443412 0.971448142604867 0.685185185185185 23.2 23 2 abnormal facial morphology 3.30392708841529e-05 0.000465638449429634 0.970066281804576 0.684210526315789 23.2 23 2 impaired branching involved in ureteric bud morphogenesis 0.000681800990928918 0.00590933785691875 0.970066281804576 0.684210526315789 23.2 23 2 enlarged adrenal glands 0.015841457942545 0.0713738957272022 0.970066281804576 0.684210526315789 23.2 23 2 short vibrissae 0.015841457942545 0.0713738957272022 0.970066281804576 0.684210526315789 23.2 23 2 abnormal stationary movement 0.015841457942545 0.0713738957272022 0.970066281804576 0.684210526315789 23.2 23 2 abnormal metatarsal bone morphology 0.015841457942545 0.0713738957272022 0.970066281804576 0.684210526315789 23.2 23 2 abnormal digestive system development 0.015841457942545 0.0713738957272022 0.970066281804576 0.684210526315789 23.2 23 2 abnormal sternebra morphology 0.015841457942545 0.0713738957272022 0.970066281804576 0.684210526315789 23.2 23 2 absent amnion 0.015841457942545 0.0713738957272022 0.970066281804576 0.684210526315789 23.2 23 2 increased liver cholesterol level 0.015841457942545 0.0713738957272022 0.970066281804576 0.684210526315789 23.2 23 2 reduced fertility 1.12043774165087e-10 4.88962961816935e-09 0.968992605787083 0.683453237410072 23.2 23 2 increased heart weight 1.12043774165087e-10 4.88962961816935e-09 0.968992605787083 0.683453237410072 23.2 23 2 increased erythrocyte cell number 2.18706399307441e-05 0.000323828671593607 0.968822607084313 0.683333333333333 23.2 23 2 sparse hair 7.4471074482648e-07 1.4939257885128e-05 0.968246270018826 0.682926829268293 23.2 23 2 liver fibrosis 0.000446802398366624 0.00413516970052526 0.968246270018826 0.682926829268293 23.2 23 2 abnormal myelopoiesis 0.00029334657485228 0.00295424941273299 0.966674441658406 0.681818181818182 23.2 23 2 abnormal astrocyte morphology 0.00029334657485228 0.00295424941273299 0.966674441658406 0.681818181818182 23.2 23 2 muscular atrophy 0.00029334657485228 0.00295424941273299 0.966674441658406 0.681818181818182 23.2 23 2 renal interstitial fibrosis 0.00029334657485228 0.00295424941273299 0.966674441658406 0.681818181818182 23.2 23 2 cochlear hair cell degeneration 0.00029334657485228 0.00295424941273299 0.966674441658406 0.681818181818182 23.2 23 2 decreased blood urea nitrogen level 0.00029334657485228 0.00295424941273299 0.966674441658406 0.681818181818182 23.2 23 2 embryonic lethality, incomplete penetrance 0.00029334657485228 0.00295424941273299 0.966674441658406 0.681818181818182 23.2 23 2 abnormal long bone epiphysis morphology 0.0100941519433462 0.0525847182388975 0.966674441658406 0.681818181818182 23.2 23 2 abnormal enterocyte morphology 0.0100941519433462 0.0525847182388975 0.966674441658406 0.681818181818182 23.2 23 2 abnormal tail movements 0.0100941519433462 0.0525847182388975 0.966674441658406 0.681818181818182 23.2 23 2 increased activated T cell number 0.0100941519433462 0.0525847182388975 0.966674441658406 0.681818181818182 23.2 23 2 intracerebral hemorrhage 0.0100941519433462 0.0525847182388975 0.966674441658406 0.681818181818182 23.2 23 2 decreased cardiac output 0.0100941519433462 0.0525847182388975 0.966674441658406 0.681818181818182 23.2 23 2 parakeratosis 0.0100941519433462 0.0525847182388975 0.966674441658406 0.681818181818182 23.2 23 2 abnormal retinal outer plexiform layer morphology 0.0100941519433462 0.0525847182388975 0.966674441658406 0.681818181818182 23.2 23 2 prolonged PR interval 0.0100941519433462 0.0525847182388975 0.966674441658406 0.681818181818182 23.2 23 2 decreased circulating estradiol level 0.0100941519433462 0.0525847182388975 0.966674441658406 0.681818181818182 23.2 23 2 abnormal sternum morphology 6.37239202144553e-06 0.00010497566326719 0.96574045669062 0.681159420289855 23.2 23 2 pulmonary hypoplasia 0.000192910861602632 0.00208637290537629 0.965303272237614 0.680851063829787 23.2 23 2 abnormal T-helper 1 physiology 0.000192910861602632 0.00208637290537629 0.965303272237614 0.680851063829787 23.2 23 2 abnormal inflammatory response 4.23004691704309e-06 7.29185811163647e-05 0.964884303803483 0.680555555555556 23.2 23 2 abnormal forebrain development 4.23004691704309e-06 7.29185811163647e-05 0.964884303803483 0.680555555555556 23.2 23 2 kidney inflammation 0.000127046057668203 0.0014664829162397 0.964096643147317 0.68 23.2 23 2 ruffled hair 0.00647532341304809 0.036359744898323 0.964096643147317 0.68 23.2 23 2 mandible hypoplasia 0.00647532341304809 0.036359744898323 0.964096643147317 0.68 23.2 23 2 abnormal egg cylinder morphology 0.00647532341304809 0.036359744898323 0.964096643147317 0.68 23.2 23 2 abnormal coat/ hair morphology 8.37772461890573e-05 0.00102405847614388 0.963026613576676 0.679245283018868 23.2 23 2 decreased heart weight 1.2412752079066e-06 2.34803960431002e-05 0.962696357536355 0.679012345679012 23.2 23 2 straub tail 0.00417596559259362 0.0259692860289416 0.962071230031461 0.678571428571429 23.2 23 2 abnormal renal tubule epithelium morphology 0.00417596559259362 0.0259692860289416 0.962071230031461 0.678571428571429 23.2 23 2 prolonged QRS complex duration 0.00417596559259362 0.0259692860289416 0.962071230031461 0.678571428571429 23.2 23 2 abnormal bone mineralization 3.84565261750094e-09 1.30150488245355e-07 0.960815808678658 0.677685950413223 23.2 23 2 osteopetrosis 0.00270470060847416 0.0184282762269347 0.960437832357384 0.67741935483871 23.2 23 2 autoimmune response 0.00270470060847416 0.0184282762269347 0.960437832357384 0.67741935483871 23.2 23 2 decreased thymus weight 0.00270470060847416 0.0184282762269347 0.960437832357384 0.67741935483871 23.2 23 2 decreased double-negative T cell number 0.00270470060847416 0.0184282762269347 0.960437832357384 0.67741935483871 23.2 23 2 retinal degeneration 1.6222982761774e-07 3.86169087271893e-06 0.959961424702445 0.677083333333333 23.2 23 2 overexpanded pulmonary alveoli 0.00175802588085421 0.0134349904105218 0.959092681331673 0.676470588235294 23.2 23 2 increased width of hypertrophic chondrocyte zone 0.00175802588085421 0.0134349904105218 0.959092681331673 0.676470588235294 23.2 23 2 increased blood urea nitrogen level 1.52879036316364e-10 6.50062568952059e-09 0.958229929294493 0.675862068965517 23.2 23 2 increased circulating phosphate level 0.00114611756463175 0.00919666916781123 0.957965662904726 0.675675675675676 23.2 23 2 abnormal posture 2.05768498147742e-06 3.74981054316855e-05 0.957007697241822 0.675 23.2 23 2 abnormal pancreatic beta cell morphology 0.000749098858900023 0.00645886797751753 0.957007697241822 0.675 23.2 23 2 increased circulating creatinine level 9.09267308960827e-07 1.76703314925005e-05 0.956183401206299 0.674418604651163 23.2 23 2 abnormal homeostasis 0.000490684796721954 0.00443041173083797 0.956183401206299 0.674418604651163 23.2 23 2 abnormal immune system morphology 0.00032202984319624 0.00319143121494281 0.955466622044975 0.673913043478261 23.2 23 2 increased T cell derived lymphoma incidence 0.000211698770664398 0.00226494921302232 0.954837611760548 0.673469387755102 23.2 23 2 abnormal pulmonary alveolus morphology 1.18874236535203e-07 2.90508920441832e-06 0.954551131829026 0.673267326732673 23.2 23 2 perinatal lethality, incomplete penetrance 2.96322058335304e-15 3.07125466712112e-13 0.953557325340917 0.672566371681416 23.2 23 2 abnormal NK cell physiology 4.00676828887299e-05 0.000550653929202849 0.952940269263259 0.672131147540984 23.2 23 2 decreased white adipose tissue amount 1.75403638756039e-05 0.000265238025170605 0.952246464917236 0.671641791044776 23.2 23 2 decreased hematocrit 2.76047637719808e-10 1.1349892542612e-08 0.951666710600695 0.671232876712329 23.2 23 2 abnormal fertility/fecundity 7.70311592199388e-06 0.000124830624468793 0.951666710600695 0.671232876712329 23.2 23 2 cardiac fibrosis 1.4969836137685e-06 2.81037489754653e-05 0.950752744972267 0.670588235294118 23.2 23 2 abnormal testis morphology 2.56757823920448e-08 7.29925813716703e-07 0.949302321257588 0.669565217391304 23.2 23 2 hydroencephaly 2.56757823920448e-08 7.29925813716703e-07 0.949302321257588 0.669565217391304 23.2 23 2 decreased total body fat amount 4.51281302061117e-21 9.35468532397524e-19 0.946607746661904 0.667664670658683 23.2 23 2 kinked tail 2.12513791453664e-07 4.84979868111e-06 0.94519278739933 0.666666666666667 23.2 23 2 abnormal gastrulation 0.000229933286509405 0.00243905778333537 0.94519278739933 0.666666666666667 23.2 23 2 abnormal dendritic spine morphology 0.000229933286509405 0.00243905778333537 0.94519278739933 0.666666666666667 23.2 23 2 abnormal adrenal gland morphology 0.0108905147839816 0.0545073551813968 0.94519278739933 0.666666666666667 23.2 23 2 decreased body height 0.0108905147839816 0.0545073551813968 0.94519278739933 0.666666666666667 23.2 23 2 abnormal body weight 0.0108905147839816 0.0545073551813968 0.94519278739933 0.666666666666667 23.2 23 2 curly vibrissae 0.0108905147839816 0.0545073551813968 0.94519278739933 0.666666666666667 23.2 23 2 ocular hypertelorism 0.0108905147839816 0.0545073551813968 0.94519278739933 0.666666666666667 23.2 23 2 abnormal nursing 0.0108905147839816 0.0545073551813968 0.94519278739933 0.666666666666667 23.2 23 2 hemolytic anemia 0.0108905147839816 0.0545073551813968 0.94519278739933 0.666666666666667 23.2 23 2 abnormal cardiac muscle contractility 0.0108905147839816 0.0545073551813968 0.94519278739933 0.666666666666667 23.2 23 2 decreased fatty acid level 0.0108905147839816 0.0545073551813968 0.94519278739933 0.666666666666667 23.2 23 2 abnormal inner cell mass apoptosis 0.0108905147839816 0.0545073551813968 0.94519278739933 0.666666666666667 23.2 23 2 abnormal mineral level 0.0695754948406059 0.214474052651097 0.94519278739933 0.666666666666667 23.2 23 2 mesocardia 0.0695754948406059 0.214474052651097 0.94519278739933 0.666666666666667 23.2 23 2 abnormal superior cervical ganglion morphology 0.0695754948406059 0.214474052651097 0.94519278739933 0.666666666666667 23.2 23 2 abnormal mating frequency 0.0695754948406059 0.214474052651097 0.94519278739933 0.666666666666667 23.2 23 2 abnormal respiratory function 0.0695754948406059 0.214474052651097 0.94519278739933 0.666666666666667 23.2 23 2 small thyroid gland 0.0695754948406059 0.214474052651097 0.94519278739933 0.666666666666667 23.2 23 2 loss of dopaminergic neurons 0.0695754948406059 0.214474052651097 0.94519278739933 0.666666666666667 23.2 23 2 dilated bile duct 0.0695754948406059 0.214474052651097 0.94519278739933 0.666666666666667 23.2 23 2 decreased circulating ketone body level 0.0695754948406059 0.214474052651097 0.94519278739933 0.666666666666667 23.2 23 2 delayed somite formation 0.0695754948406059 0.214474052651097 0.94519278739933 0.666666666666667 23.2 23 2 abnormal nucleotide metabolism 0.0695754948406059 0.214474052651097 0.94519278739933 0.666666666666667 23.2 23 2 increased skeletal muscle glycogen level 0.0695754948406059 0.214474052651097 0.94519278739933 0.666666666666667 23.2 23 2 hypoglycemia 7.20429266240883e-07 1.46291248961159e-05 0.94519278739933 0.666666666666667 23.2 23 2 lethargy 7.20429266240883e-07 1.46291248961159e-05 0.94519278739933 0.666666666666667 23.2 23 2 abnormal cell migration 0.000532578590663462 0.0047313901581263 0.94519278739933 0.666666666666667 23.2 23 2 cardiomyopathy 0.000532578590663462 0.0047313901581263 0.94519278739933 0.666666666666667 23.2 23 2 abnormal cartilage morphology 0.000812699635003828 0.0069710011795587 0.94519278739933 0.666666666666667 23.2 23 2 abnormal muscle morphology 0.000812699635003828 0.0069710011795587 0.94519278739933 0.666666666666667 23.2 23 2 impaired macrophage chemotaxis 0.00124278211176555 0.00990399234519323 0.94519278739933 0.666666666666667 23.2 23 2 abnormal anxiety-related response 0.0170559556160644 0.0763756788388123 0.94519278739933 0.666666666666667 23.2 23 2 trunk curl 0.0170559556160644 0.0763756788388123 0.94519278739933 0.666666666666667 23.2 23 2 increased incidence of induced tumors 0.0170559556160644 0.0763756788388123 0.94519278739933 0.666666666666667 23.2 23 2 liver inflammation 1.86473032982397e-08 5.48936887033979e-07 0.94519278739933 0.666666666666667 23.2 23 2 short limbs 1.62902157149254e-06 3.02402325305051e-05 0.94519278739933 0.666666666666667 23.2 23 2 cochlear outer hair cell degeneration 1.26381375954093e-05 0.000194658620858084 0.94519278739933 0.666666666666667 23.2 23 2 abnormal long bone epiphyseal plate morphology 6.59150015009838e-05 0.000838688318330932 0.94519278739933 0.666666666666667 23.2 23 2 decreased susceptibility to induced arthritis 9.98474220404102e-05 0.00119325312274393 0.94519278739933 0.666666666666667 23.2 23 2 impaired natural killer cell mediated cytotoxicity 9.98474220404102e-05 0.00119325312274393 0.94519278739933 0.666666666666667 23.2 23 2 renal hypoplasia 0.00190511527297198 0.0141251095127207 0.94519278739933 0.666666666666667 23.2 23 2 narrow eye opening 0.00190511527297198 0.0141251095127207 0.94519278739933 0.666666666666667 23.2 23 2 abnormal ovarian folliculogenesis 0.00292878107611195 0.0193759120394375 0.94519278739933 0.666666666666667 23.2 23 2 abnormal skeleton physiology 0.00292878107611195 0.0193759120394375 0.94519278739933 0.666666666666667 23.2 23 2 single kidney 0.00292878107611195 0.0193759120394375 0.94519278739933 0.666666666666667 23.2 23 2 increased osteoblast cell number 0.00292878107611195 0.0193759120394375 0.94519278739933 0.666666666666667 23.2 23 2 myeloid hyperplasia 0.00292878107611195 0.0193759120394375 0.94519278739933 0.666666666666667 23.2 23 2 abnormal hair cycle 0.00451770725963003 0.0277134323263371 0.94519278739933 0.666666666666667 23.2 23 2 abnormal microglial cell physiology 0.00451770725963003 0.0277134323263371 0.94519278739933 0.666666666666667 23.2 23 2 abnormal optic cup morphology 0.00451770725963003 0.0277134323263371 0.94519278739933 0.666666666666667 23.2 23 2 abnormal cellular respiration 0.00451770725963003 0.0277134323263371 0.94519278739933 0.666666666666667 23.2 23 2 abnormal heart valve morphology 0.00699694204638911 0.0387205636048785 0.94519278739933 0.666666666666667 23.2 23 2 abnormal trigeminal nerve morphology 0.00699694204638911 0.0387205636048785 0.94519278739933 0.666666666666667 23.2 23 2 abnormal trigeminal ganglion morphology 0.00699694204638911 0.0387205636048785 0.94519278739933 0.666666666666667 23.2 23 2 abnormal type II pneumocyte morphology 0.00699694204638911 0.0387205636048785 0.94519278739933 0.666666666666667 23.2 23 2 delayed kidney development 0.0269253069188115 0.110888577749244 0.94519278739933 0.666666666666667 23.2 23 2 abnormal phrenic nerve morphology 0.0269253069188115 0.110888577749244 0.94519278739933 0.666666666666667 23.2 23 2 absent allantois 0.0269253069188115 0.110888577749244 0.94519278739933 0.666666666666667 23.2 23 2 abnormal body wall morphology 0.0269253069188115 0.110888577749244 0.94519278739933 0.666666666666667 23.2 23 2 increased circulating glycerol level 0.0269253069188115 0.110888577749244 0.94519278739933 0.666666666666667 23.2 23 2 abnormal neutrophil morphology 0.0269253069188115 0.110888577749244 0.94519278739933 0.666666666666667 23.2 23 2 increased susceptibility to autoimmune disorder 0.0269253069188115 0.110888577749244 0.94519278739933 0.666666666666667 23.2 23 2 darkened coat color 0.0269253069188115 0.110888577749244 0.94519278739933 0.666666666666667 23.2 23 2 decreased tumor latency 0.0269253069188115 0.110888577749244 0.94519278739933 0.666666666666667 23.2 23 2 abnormal fontanelle morphology 0.0429597950873767 0.155097953962046 0.94519278739933 0.666666666666667 23.2 23 2 abnormal epidermis stratum spinosum morphology 0.0429597950873767 0.155097953962046 0.94519278739933 0.666666666666667 23.2 23 2 increased airway responsiveness 0.0429597950873767 0.155097953962046 0.94519278739933 0.666666666666667 23.2 23 2 abnormal glial cell morphology 0.0429597950873767 0.155097953962046 0.94519278739933 0.666666666666667 23.2 23 2 abnormal ear development 0.0429597950873767 0.155097953962046 0.94519278739933 0.666666666666667 23.2 23 2 abnormal dendritic cell morphology 0.0429597950873767 0.155097953962046 0.94519278739933 0.666666666666667 23.2 23 2 ostium primum atrial septal defect 0.0429597950873767 0.155097953962046 0.94519278739933 0.666666666666667 23.2 23 2 bicuspid aortic valve 0.0429597950873767 0.155097953962046 0.94519278739933 0.666666666666667 23.2 23 2 decreased trabecular bone mass 0.0429597950873767 0.155097953962046 0.94519278739933 0.666666666666667 23.2 23 2 abnormal branching involved in lung morphogenesis 0.0429597950873767 0.155097953962046 0.94519278739933 0.666666666666667 23.2 23 2 abnormal head movements 0.115264405451372 0.305736737517484 0.94519278739933 0.666666666666667 23.2 23 2 abnormal urinary bladder urothelium morphology 0.115264405451372 0.305736737517484 0.94519278739933 0.666666666666667 23.2 23 2 abnormal sympathetic neuron morphology 0.115264405451372 0.305736737517484 0.94519278739933 0.666666666666667 23.2 23 2 abnormal geniculate ganglion morphology 0.115264405451372 0.305736737517484 0.94519278739933 0.666666666666667 23.2 23 2 abnormal vagina epithelium morphology 0.115264405451372 0.305736737517484 0.94519278739933 0.666666666666667 23.2 23 2 psoriasis 0.115264405451372 0.305736737517484 0.94519278739933 0.666666666666667 23.2 23 2 multifocal hepatic necrosis 0.115264405451372 0.305736737517484 0.94519278739933 0.666666666666667 23.2 23 2 abnormal thymus lobule morphology 0.115264405451372 0.305736737517484 0.94519278739933 0.666666666666667 23.2 23 2 abnormal posterior semicircular canal morphology 0.115264405451372 0.305736737517484 0.94519278739933 0.666666666666667 23.2 23 2 decreased circulating bicarbonate level 0.115264405451372 0.305736737517484 0.94519278739933 0.666666666666667 23.2 23 2 genetic imprinting 0.115264405451372 0.305736737517484 0.94519278739933 0.666666666666667 23.2 23 2 abnormal lens capsule morphology 0.115264405451372 0.305736737517484 0.94519278739933 0.666666666666667 23.2 23 2 biliary cyst 0.115264405451372 0.305736737517484 0.94519278739933 0.666666666666667 23.2 23 2 priapism 0.115264405451372 0.305736737517484 0.94519278739933 0.666666666666667 23.2 23 2 short frontal bone 0.115264405451372 0.305736737517484 0.94519278739933 0.666666666666667 23.2 23 2 decreased cochlear hair cell number 0.115264405451372 0.305736737517484 0.94519278739933 0.666666666666667 23.2 23 2 abnormal posterior eye segment morphology 0.115264405451372 0.305736737517484 0.94519278739933 0.666666666666667 23.2 23 2 decreased susceptibility to atherosclerosis 0.115264405451372 0.305736737517484 0.94519278739933 0.666666666666667 23.2 23 2 abnormal hippocampus granule cell morphology 0.115264405451372 0.305736737517484 0.94519278739933 0.666666666666667 23.2 23 2 abnormal cerebellar layer morphology 0.115264405451372 0.305736737517484 0.94519278739933 0.666666666666667 23.2 23 2 abnormal incisor color 0.115264405451372 0.305736737517484 0.94519278739933 0.666666666666667 23.2 23 2 retropulsion 0.115264405451372 0.305736737517484 0.94519278739933 0.666666666666667 23.2 23 2 shortened ST segment 0.115264405451372 0.305736737517484 0.94519278739933 0.666666666666667 23.2 23 2 iris coloboma 0.115264405451372 0.305736737517484 0.94519278739933 0.666666666666667 23.2 23 2 fusion of atlas and occipital bones 0.115264405451372 0.305736737517484 0.94519278739933 0.666666666666667 23.2 23 2 decreased airway resistance 0.115264405451372 0.305736737517484 0.94519278739933 0.666666666666667 23.2 23 2 abnormal oxidative phosphorylation 0.115264405451372 0.305736737517484 0.94519278739933 0.666666666666667 23.2 23 2 increased myeloid cell number 0.115264405451372 0.305736737517484 0.94519278739933 0.666666666666667 23.2 23 2 abnormal ductus venosus valve topology 0.115264405451372 0.305736737517484 0.94519278739933 0.666666666666667 23.2 23 2 decreased fatty acid oxidation 0.115264405451372 0.305736737517484 0.94519278739933 0.666666666666667 23.2 23 2 decreased bone mineral density of femur 0.115264405451372 0.305736737517484 0.94519278739933 0.666666666666667 23.2 23 2 increased endoplasmic reticulum stress 0.115264405451372 0.305736737517484 0.94519278739933 0.666666666666667 23.2 23 2 decreased platelet dense granule number 0.115264405451372 0.305736737517484 0.94519278739933 0.666666666666667 23.2 23 2 limb grasping 6.36304844616003e-12 3.51735177996068e-10 0.942596103917464 0.664835164835165 23.2 23 2 abnormal seminiferous tubule morphology 7.98723064803608e-10 2.94344240547996e-08 0.941955825798647 0.664383561643836 23.2 23 2 cardiac hypertrophy 5.19184352295246e-07 1.08984900956491e-05 0.940370375218721 0.663265306122449 23.2 23 2 abnormal enzyme/coenzyme activity 2.57922361414619e-10 1.06930312336478e-08 0.939172451173857 0.662420382165605 23.2 23 2 abnormal T cell activation 1.36556346521156e-05 0.000209036253520847 0.938806349646632 0.662162162162162 23.2 23 2 decreased circulating alanine transaminase level 3.11063546963322e-05 0.000439642371063218 0.938242840433159 0.661764705882353 23.2 23 2 increased bone mineral content 1.65509893605096e-07 3.92100819373977e-06 0.936521293936951 0.660550458715596 23.2 23 2 abnormal mesoderm development 0.000247481830296155 0.00259762568203481 0.936275874310657 0.660377358490566 23.2 23 2 abnormal placenta development 0.000247481830296155 0.00259762568203481 0.936275874310657 0.660377358490566 23.2 23 2 abnormal liver physiology 5.59643396535373e-07 1.16494807437803e-05 0.935740859525337 0.66 23.2 23 2 decreased circulating alkaline phosphatase level 0.000376024625304073 0.00359754329016878 0.935740859525337 0.66 23.2 23 2 hepatic necrosis 0.000572197870033859 0.00505627780358517 0.935137544980188 0.659574468085106 23.2 23 2 decreased bone trabecula number 0.000572197870033859 0.00505627780358517 0.935137544980188 0.659574468085106 23.2 23 2 decreased circulating glucose level 8.17798440987218e-17 1.01713681097785e-14 0.935029424093961 0.659498207885305 23.2 23 2 increased tumor growth/size 0.001332099175643 0.0105026836748398 0.933666046089582 0.658536585365854 23.2 23 2 decreased body weight 5.86736635114795e-70 9.73004919898702e-67 0.933358790465009 0.658319870759289 23.2 23 2 abnormal visceral yolk sac morphology 9.73328225596608e-06 0.0001542136281001 0.933228321736047 0.658227848101266 23.2 23 2 abnormal bone structure 5.77814227650133e-12 3.22991660961732e-10 0.932949357510738 0.658031088082902 23.2 23 2 abnormal frontal bone morphology 0.00203903405252182 0.0149804926086802 0.932756040196707 0.657894736842105 23.2 23 2 abnormal compact bone morphology 0.00203903405252182 0.0149804926086802 0.932756040196707 0.657894736842105 23.2 23 2 increased circulating HDL cholesterol level 4.0020827768609e-07 8.73261483108903e-06 0.931690033293625 0.657142857142857 23.2 23 2 thick pulmonary interalveolar septum 0.00312922122862751 0.0205652253796854 0.931690033293625 0.657142857142857 23.2 23 2 abnormal dermal layer morphology 0.00312922122862751 0.0205652253796854 0.931690033293625 0.657142857142857 23.2 23 2 ovary cysts 0.00312922122862751 0.0205652253796854 0.931690033293625 0.657142857142857 23.2 23 2 abnormal midbrain development 0.00312922122862751 0.0205652253796854 0.931690033293625 0.657142857142857 23.2 23 2 abnormal hippocampus pyramidal cell morphology 0.00312922122862751 0.0205652253796854 0.931690033293625 0.657142857142857 23.2 23 2 decreased compact bone thickness 5.03782670154764e-05 0.0006611582397104 0.931085432363519 0.656716417910448 23.2 23 2 abnormal neuron morphology 9.01645167065148e-07 1.7590920416271e-05 0.930871684559946 0.656565656565657 23.2 23 2 decreased eosinophil cell number 7.61298099928744e-05 0.000954019659230605 0.930424150096215 0.65625 23.2 23 2 kidney cortex cysts 0.00481686407979885 0.0292193431043527 0.930424150096215 0.65625 23.2 23 2 polydipsia 0.00481686407979885 0.0292193431043527 0.930424150096215 0.65625 23.2 23 2 abnormal depression-related behavior 0.00481686407979885 0.0292193431043527 0.930424150096215 0.65625 23.2 23 2 bradykinesia 0.00481686407979885 0.0292193431043527 0.930424150096215 0.65625 23.2 23 2 abnormal long bone morphology 0.000115147989333849 0.00134790881631976 0.929697823671472 0.655737704918033 23.2 23 2 increased osteoclast cell number 0.000115147989333849 0.00134790881631976 0.929697823671472 0.655737704918033 23.2 23 2 decreased body size 3.94465914019618e-44 2.80352560321086e-41 0.929202683853101 0.655388471177945 23.2 23 2 thrombocytosis 0.000174336330787893 0.00191462085136814 0.928896360030376 0.655172413793103 23.2 23 2 increased susceptibility to induced arthritis 0.00744139397740896 0.0409977132199442 0.928896360030376 0.655172413793103 23.2 23 2 short sternum 0.00744139397740896 0.0409977132199442 0.928896360030376 0.655172413793103 23.2 23 2 abnormal CD8-positive, alpha-beta T cell physiology 0.00744139397740896 0.0409977132199442 0.928896360030376 0.655172413793103 23.2 23 2 abnormal T-helper 2 physiology 0.000264237931975671 0.00272735209871154 0.928007463992069 0.654545454545455 23.2 23 2 abnormal skeleton development 1.0403719792924e-05 0.000163276044068759 0.927689217262305 0.654320987654321 23.2 23 2 decreased cardiac muscle contractility 6.41920050572306e-07 1.32512541560051e-05 0.927016003026266 0.653846153846154 23.2 23 2 abnormal skin condition 0.000400987772026936 0.00380289407960046 0.927016003026266 0.653846153846154 23.2 23 2 abnormal xiphoid process morphology 0.0115458521293683 0.0574406143436071 0.927016003026266 0.653846153846154 23.2 23 2 abnormal leukocyte cell number 0.0115458521293683 0.0574406143436071 0.927016003026266 0.653846153846154 23.2 23 2 abnormal Schwann cell morphology 0.0115458521293683 0.0574406143436071 0.927016003026266 0.653846153846154 23.2 23 2 increased susceptibility to otitis media 0.0115458521293683 0.0574406143436071 0.927016003026266 0.653846153846154 23.2 23 2 decreased bone resorption 0.0115458521293683 0.0574406143436071 0.927016003026266 0.653846153846154 23.2 23 2 postnatal growth retardation 1.33459323594342e-33 6.63960134881854e-31 0.926659595489539 0.65359477124183 23.2 23 2 abnormal limb morphology 2.35994859390428e-05 0.000347359297475555 0.926288931651343 0.653333333333333 23.2 23 2 decreased body length 8.60622409604826e-16 9.73090110860002e-14 0.926219939477081 0.653284671532847 23.2 23 2 absent kidney 0.000609337053821688 0.00534647591316208 0.925903138676895 0.653061224489796 23.2 23 2 abnormal locomotor behavior 3.25902969005429e-06 5.74952932908515e-05 0.92464511810804 0.652173913043478 23.2 23 2 abnormal cranial nerve morphology 0.018009758860972 0.0802854393667884 0.92464511810804 0.652173913043478 23.2 23 2 failure of embryo implantation 0.018009758860972 0.0802854393667884 0.92464511810804 0.652173913043478 23.2 23 2 pancreas inflammation 0.018009758860972 0.0802854393667884 0.92464511810804 0.652173913043478 23.2 23 2 abnormal cochlear ganglion morphology 0.018009758860972 0.0802854393667884 0.92464511810804 0.652173913043478 23.2 23 2 increased susceptibility to fungal infection 0.018009758860972 0.0802854393667884 0.92464511810804 0.652173913043478 23.2 23 2 abnormal skin morphology 8.10116905012015e-05 0.000992692512914969 0.923711133140254 0.651515151515151 23.2 23 2 abnormal vasculogenesis 0.00141379399979666 0.0110072381048332 0.923211559785392 0.651162790697674 23.2 23 2 abnormal blood circulation 0.00141379399979666 0.0110072381048332 0.923211559785392 0.651162790697674 23.2 23 2 decreased oxygen consumption 0.00141379399979666 0.0110072381048332 0.923211559785392 0.651162790697674 23.2 23 2 cyanosis 2.5163935711092e-11 1.27745489961921e-09 0.923039831444658 0.651041666666667 23.2 23 2 short tail 1.10653197937562e-05 0.000173113100546972 0.922417057582479 0.650602409638554 23.2 23 2 abnormal incisor morphology 0.000185070654729411 0.00201471883430814 0.921562967714347 0.65 23.2 23 2 abnormal cell proliferation 0.0282808583561684 0.113004200373903 0.921562967714347 0.65 23.2 23 2 abnormal circulating enzyme level 0.0282808583561684 0.113004200373903 0.921562967714347 0.65 23.2 23 2 abnormal hyoid bone morphology 0.0282808583561684 0.113004200373903 0.921562967714347 0.65 23.2 23 2 abnormal lens epithelium morphology 0.0282808583561684 0.113004200373903 0.921562967714347 0.65 23.2 23 2 absent placental labyrinth 0.0282808583561684 0.113004200373903 0.921562967714347 0.65 23.2 23 2 abnormal induced retinal neovascularization 0.0282808583561684 0.113004200373903 0.921562967714347 0.65 23.2 23 2 premature death 3.0275851863407e-45 2.5103727170075e-42 0.92049262744987 0.64924506387921 23.2 23 2 decreased brain weight 0.000280118672044051 0.00286158191667178 0.920319292994084 0.649122807017544 23.2 23 2 decreased bone mineral content 5.73345011724633e-12 3.22991660961732e-10 0.920199708886367 0.649038461538462 23.2 23 2 cleft palate 4.56658923751459e-08 1.20205192892249e-06 0.919939544987897 0.648854961832061 23.2 23 2 increased erythroid progenitor cell number 0.00330634181144624 0.0215866804618701 0.919647036388537 0.648648648648649 23.2 23 2 decreased width of hypertrophic chondrocyte zone 0.00330634181144624 0.0215866804618701 0.919647036388537 0.648648648648649 23.2 23 2 abnormal hair follicle development 0.00330634181144624 0.0215866804618701 0.919647036388537 0.648648648648649 23.2 23 2 skin inflammation 0.00330634181144624 0.0215866804618701 0.919647036388537 0.648648648648649 23.2 23 2 abnormal humerus morphology 0.00330634181144624 0.0215866804618701 0.919647036388537 0.648648648648649 23.2 23 2 decreased grip strength 1.83358791372608e-12 1.126185169233e-10 0.919297094593869 0.648401826484018 23.2 23 2 increased neutrophil cell number 9.69802126700205e-09 3.05364910147691e-07 0.919118503609004 0.648275862068965 23.2 23 2 abnormal axon morphology 7.24938830500339e-07 1.46608564298341e-05 0.918937432193793 0.648148148148148 23.2 23 2 decreased platelet aggregation 0.000424433393144518 0.00395422496422093 0.918937432193793 0.648148148148148 23.2 23 2 atelectasis 5.68470905474594e-05 0.000732679470138888 0.918567638458504 0.647887323943662 23.2 23 2 corneal opacity 5.68470905474594e-05 0.000732679470138888 0.918567638458504 0.647887323943662 23.2 23 2 increased circulating free fatty acid level 5.68470905474594e-05 0.000732679470138888 0.918567638458504 0.647887323943662 23.2 23 2 distended abdomen 0.000643858746427622 0.00562952067394977 0.917392999534644 0.647058823529412 23.2 23 2 abnormal vision 0.00507516560075117 0.0297396335261921 0.917392999534644 0.647058823529412 23.2 23 2 abnormal nervous system development 0.00507516560075117 0.0297396335261921 0.917392999534644 0.647058823529412 23.2 23 2 decreased regulatory T cell number 0.00507516560075117 0.0297396335261921 0.917392999534644 0.647058823529412 23.2 23 2 decreased cytotoxic T cell cytolysis 0.00507516560075117 0.0297396335261921 0.917392999534644 0.647058823529412 23.2 23 2 increased incidence of corneal inflammation 0.0447954440271944 0.160675799592857 0.917392999534644 0.647058823529412 23.2 23 2 abnormal involuntary movement 0.0447954440271944 0.160675799592857 0.917392999534644 0.647058823529412 23.2 23 2 abnormal tarsal bone morphology 0.0447954440271944 0.160675799592857 0.917392999534644 0.647058823529412 23.2 23 2 pancytopenia 0.0447954440271944 0.160675799592857 0.917392999534644 0.647058823529412 23.2 23 2 increased trabecular bone mass 0.0447954440271944 0.160675799592857 0.917392999534644 0.647058823529412 23.2 23 2 decreased body fat mass 0.0447954440271944 0.160675799592857 0.917392999534644 0.647058823529412 23.2 23 2 abnormal cell cytoskeleton morphology 0.0447954440271944 0.160675799592857 0.917392999534644 0.647058823529412 23.2 23 2 abnormal cardiovascular system physiology 4.83586619894649e-08 1.26623338630309e-06 0.916765936650478 0.646616541353383 23.2 23 2 abnormal motor coordination/ balance 2.43982934145792e-06 4.39788078759173e-05 0.916550581720562 0.646464646464647 23.2 23 2 decreased monocyte cell number 0.000129316979562008 0.00148580132406695 0.916109932402428 0.646153846153846 23.2 23 2 increased eosinophil cell number 0.000195256654445806 0.00210260141962745 0.914702697483223 0.645161290322581 23.2 23 2 albuminuria 0.00148777887661933 0.0115471137459924 0.913686361152686 0.644444444444444 23.2 23 2 cachexia 1.71781224210108e-06 3.16522811276033e-05 0.913383414746468 0.644230769230769 23.2 23 2 abnormal retinal pigmentation 1.23502480201417e-05 0.000191409607165748 0.912599932661422 0.64367816091954 23.2 23 2 ataxia 3.35293488319008e-11 1.66808510438706e-09 0.912438581895393 0.643564356435644 23.2 23 2 abnormal skeleton morphology 5.39913582171127e-07 1.12860087029469e-05 0.912316516533266 0.643478260869565 23.2 23 2 abnormal pancreas morphology 0.00226701834879351 0.0160432664086028 0.911435902135068 0.642857142857143 23.2 23 2 abnormal reproductive system morphology 0.00226701834879351 0.0160432664086028 0.911435902135068 0.642857142857143 23.2 23 2 abnormal coat/hair pigmentation 8.07481322677491e-07 1.60048588857391e-05 0.911435902135068 0.642857142857143 23.2 23 2 abnormal seminal vesicle morphology 0.000446285323541046 0.00413516970052526 0.911435902135068 0.642857142857143 23.2 23 2 abnormal spleen germinal center morphology 0.0120746996632209 0.058153927832878 0.911435902135068 0.642857142857143 23.2 23 2 abnormal blood flow velocity 0.0717841737444443 0.216197682213417 0.911435902135068 0.642857142857143 23.2 23 2 absent visceral yolk sac blood islands 0.0717841737444443 0.216197682213417 0.911435902135068 0.642857142857143 23.2 23 2 abnormal antigen presentation 0.0717841737444443 0.216197682213417 0.911435902135068 0.642857142857143 23.2 23 2 increased lactate dehydrogenase level 0.0717841737444443 0.216197682213417 0.911435902135068 0.642857142857143 23.2 23 2 abnormal positive T cell selection 0.0717841737444443 0.216197682213417 0.911435902135068 0.642857142857143 23.2 23 2 increased pulmonary respiratory rate 0.0717841737444443 0.216197682213417 0.911435902135068 0.642857142857143 23.2 23 2 abnormal renal glomerulus morphology 1.20780137238111e-06 2.29343962885344e-05 0.910506813549813 0.642201834862385 23.2 23 2 decreased birth weight 5.77343540958124e-06 9.63853730290828e-05 0.910369895231986 0.642105263157895 23.2 23 2 abnormal pancreatic islet morphology 0.000675682615124116 0.00588501121092037 0.909525135044638 0.641509433962264 23.2 23 2 abnormal spermatogenesis 3.6625854809143e-10 1.46946473931844e-08 0.909234366139573 0.641304347826087 23.2 23 2 abnormal cornea morphology 4.18188096162061e-05 0.000565349396306048 0.908839218653202 0.641025641025641 23.2 23 2 abnormal heart looping 0.003460912518158 0.0225367012798901 0.908839218653202 0.641025641025641 23.2 23 2 abnormal osteoclast physiology 0.000204858727906443 0.00219649174856585 0.908271194141544 0.640625 23.2 23 2 abnormal muscle physiology 1.29684005522459e-05 0.000199128989961184 0.908022284524075 0.640449438202247 23.2 23 2 abnormal primitive streak morphology 0.0187397438878634 0.0834648396079862 0.907385075903357 0.64 23.2 23 2 weight loss 1.20965288736074e-09 4.3295130321005e-08 0.907385075903357 0.64 23.2 23 2 hypoactivity 6.00482370336683e-19 9.6367735239516e-17 0.906332075981055 0.639257294429708 23.2 23 2 decreased bone mineral density 8.63698538424199e-14 6.82047655342919e-12 0.906105867619658 0.639097744360902 23.2 23 2 abnormal uterus morphology 0.00529494715017185 0.0305551235973643 0.905809754591025 0.638888888888889 23.2 23 2 abnormal retinal blood vessel morphology 0.00529494715017185 0.0305551235973643 0.905809754591025 0.638888888888889 23.2 23 2 enlarged heart 4.14894224912184e-12 2.37252732061852e-10 0.904451718976945 0.637931034482759 23.2 23 2 dermatitis 0.000466497082828714 0.00422736427517823 0.904451718976945 0.637931034482759 23.2 23 2 abnormal glucose homeostasis 8.92354799674195e-10 3.26431259439641e-08 0.903645851689469 0.637362637362637 23.2 23 2 impaired glucose tolerance 9.3156327587164e-13 5.92968773546715e-11 0.903268913764682 0.637096774193548 23.2 23 2 abnormal rib morphology 1.31569474186612e-07 3.17746667028347e-06 0.903184219070471 0.637037037037037 23.2 23 2 polyuria 6.56384160645872e-05 0.000837310563900824 0.902229478881179 0.636363636363636 23.2 23 2 decreased circulating calcium level 0.000704775450190008 0.00608725323731822 0.902229478881179 0.636363636363636 23.2 23 2 abnormal tooth development 0.008121009336251 0.0437251314370657 0.902229478881179 0.636363636363636 23.2 23 2 dilated heart atrium 0.008121009336251 0.0437251314370657 0.902229478881179 0.636363636363636 23.2 23 2 abnormal locomotor coordination 0.008121009336251 0.0437251314370657 0.902229478881179 0.636363636363636 23.2 23 2 abnormal QRS complex 0.008121009336251 0.0437251314370657 0.902229478881179 0.636363636363636 23.2 23 2 diarrhea 0.008121009336251 0.0437251314370657 0.902229478881179 0.636363636363636 23.2 23 2 increased body size 0.0292391120433214 0.113004200373903 0.902229478881179 0.636363636363636 23.2 23 2 testis hypoplasia 0.0292391120433214 0.113004200373903 0.902229478881179 0.636363636363636 23.2 23 2 abnormal retinal layer morphology 0.0292391120433214 0.113004200373903 0.902229478881179 0.636363636363636 23.2 23 2 abnormal limb posture 0.0292391120433214 0.113004200373903 0.902229478881179 0.636363636363636 23.2 23 2 abnormal basement membrane morphology 0.0292391120433214 0.113004200373903 0.902229478881179 0.636363636363636 23.2 23 2 failure of palatal shelf elevation 0.0292391120433214 0.113004200373903 0.902229478881179 0.636363636363636 23.2 23 2 decreased atrioventricular cushion size 0.116948143014226 0.305736737517484 0.902229478881179 0.636363636363636 23.2 23 2 abnormal stomach epithelium morphology 0.116948143014226 0.305736737517484 0.902229478881179 0.636363636363636 23.2 23 2 abnormal large intestine morphology 0.116948143014226 0.305736737517484 0.902229478881179 0.636363636363636 23.2 23 2 failure of somite differentiation 0.116948143014226 0.305736737517484 0.902229478881179 0.636363636363636 23.2 23 2 abnormal vestibular ganglion morphology 0.116948143014226 0.305736737517484 0.902229478881179 0.636363636363636 23.2 23 2 fatigue 0.116948143014226 0.305736737517484 0.902229478881179 0.636363636363636 23.2 23 2 allodynia 0.116948143014226 0.305736737517484 0.902229478881179 0.636363636363636 23.2 23 2 fused joints 0.116948143014226 0.305736737517484 0.902229478881179 0.636363636363636 23.2 23 2 abnormal palate development 0.116948143014226 0.305736737517484 0.902229478881179 0.636363636363636 23.2 23 2 abnormal aorta smooth muscle morphology 0.116948143014226 0.305736737517484 0.902229478881179 0.636363636363636 23.2 23 2 decreased palatine bone horizontal plate size 0.116948143014226 0.305736737517484 0.902229478881179 0.636363636363636 23.2 23 2 increased number of Howell-Jolly bodies 0.116948143014226 0.305736737517484 0.902229478881179 0.636363636363636 23.2 23 2 abnormal extraembryonic ectoderm morphology 0.116948143014226 0.305736737517484 0.902229478881179 0.636363636363636 23.2 23 2 abnormal brain ependyma motile cilium morphology 0.116948143014226 0.305736737517484 0.902229478881179 0.636363636363636 23.2 23 2 increased pancreatic beta cell proliferation 0.116948143014226 0.305736737517484 0.902229478881179 0.636363636363636 23.2 23 2 chylous ascites 0.116948143014226 0.305736737517484 0.902229478881179 0.636363636363636 23.2 23 2 hypolactation 0.116948143014226 0.305736737517484 0.902229478881179 0.636363636363636 23.2 23 2 abnormal hair follicle morphology 0.000321978201537534 0.00319143121494281 0.900183607046981 0.634920634920635 23.2 23 2 increased circulating aspartate transaminase level 0.000321978201537534 0.00319143121494281 0.900183607046981 0.634920634920635 23.2 23 2 microphthalmia 3.04366611602029e-08 8.41235495955607e-07 0.898859807624853 0.633986928104575 23.2 23 2 abnormal eating behavior 0.000485047216053116 0.00438747254520773 0.897933148029364 0.633333333333333 23.2 23 2 abnormal heart tube morphology 0.012491398308118 0.0593550206140278 0.897933148029364 0.633333333333333 23.2 23 2 abnormal response to new environment 0.012491398308118 0.0593550206140278 0.897933148029364 0.633333333333333 23.2 23 2 arrested T cell differentiation 0.012491398308118 0.0593550206140278 0.897933148029364 0.633333333333333 23.2 23 2 abnormal lactation 0.012491398308118 0.0593550206140278 0.897933148029364 0.633333333333333 23.2 23 2 emphysema 0.012491398308118 0.0593550206140278 0.897933148029364 0.633333333333333 23.2 23 2 liver hemorrhage 0.012491398308118 0.0593550206140278 0.897933148029364 0.633333333333333 23.2 23 2 abnormal fat pad morphology 0.012491398308118 0.0593550206140278 0.897933148029364 0.633333333333333 23.2 23 2 improved glucose tolerance 4.7894227147897e-10 1.84708356636269e-08 0.896968665593242 0.63265306122449 23.2 23 2 organ of Corti degeneration 0.00161295083363559 0.0124217188813267 0.896968665593242 0.63265306122449 23.2 23 2 postnatal lethality, incomplete penetrance 3.46074229255082e-26 1.22979949324574e-23 0.896102669039682 0.632042253521127 23.2 23 2 increased bone marrow cell number 0.00547886939817383 0.0314025060552014 0.895445798588839 0.631578947368421 23.2 23 2 shiny skin 0.0459261908781255 0.163122056418 0.895445798588839 0.631578947368421 23.2 23 2 increased circulating VLDL cholesterol level 0.0459261908781255 0.163122056418 0.895445798588839 0.631578947368421 23.2 23 2 shortened RR interval 0.0459261908781255 0.163122056418 0.895445798588839 0.631578947368421 23.2 23 2 embryonic lethality between implantation and somite formation, incomplete penetrance 0.0459261908781255 0.163122056418 0.895445798588839 0.631578947368421 23.2 23 2 abnormal lipid homeostasis 4.7102459783106e-07 1.02329579659804e-05 0.894297791154751 0.630769230769231 23.2 23 2 small testis 2.67151791598801e-13 1.92620313507831e-11 0.893823614171106 0.630434782608696 23.2 23 2 reduced male fertility 3.67777086451915e-11 1.776399034076e-09 0.893144726419191 0.629955947136564 23.2 23 2 increased or absent threshold for auditory brainstem response 8.85127488528318e-14 6.88048321160684e-12 0.892863774948156 0.629757785467128 23.2 23 2 diluted coat color 0.00110280629248942 0.00886342698729384 0.892682076988256 0.62962962962963 23.2 23 2 rectal prolapse 0.0192789992704328 0.0854078551829058 0.892682076988256 0.62962962962963 23.2 23 2 abnormal bone trabecula morphology 0.0192789992704328 0.0854078551829058 0.892682076988256 0.62962962962963 23.2 23 2 respiratory failure 7.25362294682578e-08 1.84653441401874e-06 0.891986570890096 0.629139072847682 23.2 23 2 azoospermia 3.41272677197095e-08 9.3802849119091e-07 0.891691308867292 0.628930817610063 23.2 23 2 insulin resistance 4.88263955594814e-07 1.05613616481922e-05 0.891488651751641 0.628787878787879 23.2 23 2 decreased glycogen level 0.00836830223049897 0.0450078957802512 0.891181770976511 0.628571428571429 23.2 23 2 increased rib number 0.000105885337304958 0.00125723043697415 0.890662434280138 0.628205128205128 23.2 23 2 increased circulating alanine transaminase level 0.000105885337304958 0.00125723043697415 0.890662434280138 0.628205128205128 23.2 23 2 abnormal organ of Corti morphology 0.0037068344377257 0.0237954855841101 0.890239718364485 0.627906976744186 23.2 23 2 abnormal male reproductive system morphology 0.0037068344377257 0.0237954855841101 0.890239718364485 0.627906976744186 23.2 23 2 cochlear inner hair cell degeneration 0.00166454579183261 0.0127992508722832 0.889593211669958 0.627450980392157 23.2 23 2 abnormal lipid level 7.31151210759623e-05 0.00091855486705281 0.888253462857202 0.626506024096386 23.2 23 2 abnormal liver morphology 8.09719418929415e-09 2.58227827511143e-07 0.887108314430656 0.625698324022346 23.2 23 2 abnormal sensory capabilities/reflexes/nociception 0.0298751656559561 0.114557002739297 0.886118238186872 0.625 23.2 23 2 increased circulating total protein level 0.0298751656559561 0.114557002739297 0.886118238186872 0.625 23.2 23 2 abnormal truncus arteriosus septation 0.0298751656559561 0.114557002739297 0.886118238186872 0.625 23.2 23 2 small kidney 5.05005288623019e-05 0.0006611582397104 0.886118238186872 0.625 23.2 23 2 teratozoospermia 5.05005288623019e-05 0.0006611582397104 0.886118238186872 0.625 23.2 23 2 abnormal neuromuscular synapse morphology 0.000237039678710833 0.00250376306069298 0.886118238186872 0.625 23.2 23 2 abnormal digit morphology 0.000237039678710833 0.00250376306069298 0.886118238186872 0.625 23.2 23 2 abnormal female reproductive system morphology 0.00562972931756166 0.0322300383830486 0.886118238186872 0.625 23.2 23 2 reduced female fertility 6.24179425023449e-11 2.83282111289573e-09 0.886118238186872 0.625 23.2 23 2 abnormal lens morphology 1.11237110162512e-06 2.12032422627778e-05 0.886118238186872 0.625 23.2 23 2 decreased circulating LDL cholesterol level 0.000517177324256023 0.00461103438740809 0.886118238186872 0.625 23.2 23 2 abnormal vertebral body morphology 0.0128094478376802 0.0604620521750085 0.886118238186872 0.625 23.2 23 2 increased circulating follicle stimulating hormone level 0.0128094478376802 0.0604620521750085 0.886118238186872 0.625 23.2 23 2 abnormal heart atrium morphology 0.0128094478376802 0.0604620521750085 0.886118238186872 0.625 23.2 23 2 absent mandible 0.0727583321667219 0.216197682213417 0.886118238186872 0.625 23.2 23 2 vasculature congestion 0.0727583321667219 0.216197682213417 0.886118238186872 0.625 23.2 23 2 delayed hair appearance 0.0727583321667219 0.216197682213417 0.886118238186872 0.625 23.2 23 2 abnormal mouth morphology 0.0727583321667219 0.216197682213417 0.886118238186872 0.625 23.2 23 2 abnormal intestinal absorption 0.0727583321667219 0.216197682213417 0.886118238186872 0.625 23.2 23 2 abnormal meiosis 0.0727583321667219 0.216197682213417 0.886118238186872 0.625 23.2 23 2 increased pancreatic beta cell number 0.0727583321667219 0.216197682213417 0.886118238186872 0.625 23.2 23 2 abnormal amnion morphology 0.0727583321667219 0.216197682213417 0.886118238186872 0.625 23.2 23 2 blepharitis 0.0727583321667219 0.216197682213417 0.886118238186872 0.625 23.2 23 2 decreased circulating triiodothyronine level 0.0727583321667219 0.216197682213417 0.886118238186872 0.625 23.2 23 2 abnormal pulmonary alveolus wall morphology 0.0727583321667219 0.216197682213417 0.886118238186872 0.625 23.2 23 2 abnormal ear pigmentation 0.195411751295768 0.4070853915146 0.886118238186872 0.625 23.2 23 2 abnormal exoccipital bone morphology 0.195411751295768 0.4070853915146 0.886118238186872 0.625 23.2 23 2 abnormal bone marrow development 0.195411751295768 0.4070853915146 0.886118238186872 0.625 23.2 23 2 absent pre-B cells 0.195411751295768 0.4070853915146 0.886118238186872 0.625 23.2 23 2 failure of vascular branching 0.195411751295768 0.4070853915146 0.886118238186872 0.625 23.2 23 2 abnormal esophageal epithelium morphology 0.195411751295768 0.4070853915146 0.886118238186872 0.625 23.2 23 2 clubfoot 0.195411751295768 0.4070853915146 0.886118238186872 0.625 23.2 23 2 abnormal urination 0.195411751295768 0.4070853915146 0.886118238186872 0.625 23.2 23 2 abnormal atrial thrombosis 0.195411751295768 0.4070853915146 0.886118238186872 0.625 23.2 23 2 preneoplasia 0.195411751295768 0.4070853915146 0.886118238186872 0.625 23.2 23 2 abnormal hepatobiliary system morphology 0.195411751295768 0.4070853915146 0.886118238186872 0.625 23.2 23 2 abnormal thyroid physiology 0.195411751295768 0.4070853915146 0.886118238186872 0.625 23.2 23 2 vascular smooth muscle hypertrophy 0.195411751295768 0.4070853915146 0.886118238186872 0.625 23.2 23 2 decreased aerobic running capacity 0.195411751295768 0.4070853915146 0.886118238186872 0.625 23.2 23 2 altered response to CNS ischemic injury 0.195411751295768 0.4070853915146 0.886118238186872 0.625 23.2 23 2 hypospadia 0.195411751295768 0.4070853915146 0.886118238186872 0.625 23.2 23 2 abnormal umbilical artery morphology 0.195411751295768 0.4070853915146 0.886118238186872 0.625 23.2 23 2 abnormal perineum morphology 0.195411751295768 0.4070853915146 0.886118238186872 0.625 23.2 23 2 liver failure 0.195411751295768 0.4070853915146 0.886118238186872 0.625 23.2 23 2 hair follicle degeneration 0.195411751295768 0.4070853915146 0.886118238186872 0.625 23.2 23 2 increased left ventricle systolic pressure 0.195411751295768 0.4070853915146 0.886118238186872 0.625 23.2 23 2 bowed fibula 0.195411751295768 0.4070853915146 0.886118238186872 0.625 23.2 23 2 absent interparietal bone 0.195411751295768 0.4070853915146 0.886118238186872 0.625 23.2 23 2 abnormal choroid pigmentation 0.195411751295768 0.4070853915146 0.886118238186872 0.625 23.2 23 2 abnormal canal of Schlemm morphology 0.195411751295768 0.4070853915146 0.886118238186872 0.625 23.2 23 2 abnormal vertebral body development 0.195411751295768 0.4070853915146 0.886118238186872 0.625 23.2 23 2 abnormal frontonasal prominence morphology 0.195411751295768 0.4070853915146 0.886118238186872 0.625 23.2 23 2 skin fibrosis 0.195411751295768 0.4070853915146 0.886118238186872 0.625 23.2 23 2 abnormal olfactory bulb glomerular layer morphology 0.195411751295768 0.4070853915146 0.886118238186872 0.625 23.2 23 2 abnormal olfactory bulb mitral cell layer morphology 0.195411751295768 0.4070853915146 0.886118238186872 0.625 23.2 23 2 increased caudal vertebrae number 0.195411751295768 0.4070853915146 0.886118238186872 0.625 23.2 23 2 abnormal circulating serum amyloid protein level 0.195411751295768 0.4070853915146 0.886118238186872 0.625 23.2 23 2 decreased quadriceps weight 0.195411751295768 0.4070853915146 0.886118238186872 0.625 23.2 23 2 sinoatrial block 0.195411751295768 0.4070853915146 0.886118238186872 0.625 23.2 23 2 increased heart right ventricle size 0.195411751295768 0.4070853915146 0.886118238186872 0.625 23.2 23 2 lung situs inversus 0.195411751295768 0.4070853915146 0.886118238186872 0.625 23.2 23 2 abnormal anterior commissure pars posterior morphology 0.195411751295768 0.4070853915146 0.886118238186872 0.625 23.2 23 2 decreased lung compliance 0.195411751295768 0.4070853915146 0.886118238186872 0.625 23.2 23 2 abnormal branching involved in ureteric bud morphogenesis 0.195411751295768 0.4070853915146 0.886118238186872 0.625 23.2 23 2 increased circulating ferritin level 0.195411751295768 0.4070853915146 0.886118238186872 0.625 23.2 23 2 abnormal heart echocardiography feature 0.195411751295768 0.4070853915146 0.886118238186872 0.625 23.2 23 2 prolonged PQ interval 0.195411751295768 0.4070853915146 0.886118238186872 0.625 23.2 23 2 increased cornea thickness 0.195411751295768 0.4070853915146 0.886118238186872 0.625 23.2 23 2 increased circulating lactate level 0.195411751295768 0.4070853915146 0.886118238186872 0.625 23.2 23 2 increased testis apoptosis 0.195411751295768 0.4070853915146 0.886118238186872 0.625 23.2 23 2 malocclusion 0.0085619416352211 0.0459004952965786 0.881328409872348 0.621621621621622 23.2 23 2 alopecia 3.58463579498446e-05 0.000500942783147407 0.880521701945692 0.621052631578947 23.2 23 2 abnormal immune system physiology 2.51582194255362e-06 4.51848886794377e-05 0.880401346327602 0.620967741935484 23.2 23 2 abnormal spermiogenesis 0.00116419848004377 0.00931171613861379 0.880007077923514 0.620689655172414 23.2 23 2 cochlear ganglion degeneration 0.00116419848004377 0.00931171613861379 0.880007077923514 0.620689655172414 23.2 23 2 abnormal microglial cell morphology 0.0196564726036405 0.0859322945545795 0.880007077923514 0.620689655172414 23.2 23 2 abnormal spinal nerve morphology 0.0196564726036405 0.0859322945545795 0.880007077923514 0.620689655172414 23.2 23 2 aphagia 0.0196564726036405 0.0859322945545795 0.880007077923514 0.620689655172414 23.2 23 2 increased body length 0.00257368346535099 0.0178578455231816 0.879029292281377 0.62 23.2 23 2 abnormal circulating protein level 0.00257368346535099 0.0178578455231816 0.879029292281377 0.62 23.2 23 2 decreased oocyte number 0.00257368346535099 0.0178578455231816 0.879029292281377 0.62 23.2 23 2 abnormal ovary morphology 0.00036358850149939 0.00349874815272624 0.878629915047265 0.619718309859155 23.2 23 2 abnormal skeletal muscle fiber morphology 0.00036358850149939 0.00349874815272624 0.878629915047265 0.619718309859155 23.2 23 2 decreased liver weight 0.00036358850149939 0.00349874815272624 0.878629915047265 0.619718309859155 23.2 23 2 increased circulating cholesterol level 2.84977061556768e-08 7.92245181913773e-07 0.878062617839719 0.619318181818182 23.2 23 2 hydronephrosis 0.000115037868329523 0.00134790881631976 0.877679016870807 0.619047619047619 23.2 23 2 skin edema 0.00575033493038582 0.0328449096195975 0.877679016870807 0.619047619047619 23.2 23 2 abnormal scapula morphology 0.0465213253088374 0.163122056418 0.877679016870807 0.619047619047619 23.2 23 2 abnormal eye pigmentation 0.0465213253088374 0.163122056418 0.877679016870807 0.619047619047619 23.2 23 2 abnormal embryonic/fetal subventricular zone morphology 0.0465213253088374 0.163122056418 0.877679016870807 0.619047619047619 23.2 23 2 increased acute inflammation 0.0465213253088374 0.163122056418 0.877679016870807 0.619047619047619 23.2 23 2 increased keratinocyte proliferation 0.0465213253088374 0.163122056418 0.877679016870807 0.619047619047619 23.2 23 2 impaired coordination 9.99399736814379e-15 8.87859587616346e-13 0.876898510853136 0.61849710982659 23.2 23 2 abnormal axial skeleton morphology 0.000249325122499316 0.00261135259880863 0.876790677784905 0.618421052631579 23.2 23 2 male infertility 1.047881688875e-20 1.93081903783448e-18 0.876605239208325 0.618290258449304 23.2 23 2 abnormal learning/memory/conditioning 0.00174723718002181 0.0133936902474708 0.876451493770288 0.618181818181818 23.2 23 2 impaired balance 2.5343098548256e-05 0.000368660570987057 0.875693317737615 0.617647058823529 23.2 23 2 abnormal endoderm development 0.013041218447443 0.0611009995162625 0.875693317737615 0.617647058823529 23.2 23 2 abnormal skin physiology 0.013041218447443 0.0611009995162625 0.875693317737615 0.617647058823529 23.2 23 2 increased susceptibility to viral infection induced morbidity/mortality 0.013041218447443 0.0611009995162625 0.875693317737615 0.617647058823529 23.2 23 2 decreased circulating cholesterol level 2.03007062829602e-08 5.94094198574865e-07 0.87546545062397 0.617486338797814 23.2 23 2 decreased circulating HDL cholesterol level 2.64267286737033e-06 4.67875356411651e-05 0.875041760209536 0.6171875 23.2 23 2 abnormal kidney morphology 4.30604227417698e-08 1.13949788904417e-06 0.874978466049665 0.617142857142857 23.2 23 2 cleft secondary palate 5.45093116523926e-05 0.000708051763630948 0.874806090465338 0.617021276595745 23.2 23 2 abnormal hair growth 0.00262271940930393 0.0181222625851209 0.872485649907074 0.615384615384615 23.2 23 2 decreased kidney weight 0.00262271940930393 0.0181222625851209 0.872485649907074 0.615384615384615 23.2 23 2 decreased body temperature 0.00262271940930393 0.0181222625851209 0.872485649907074 0.615384615384615 23.2 23 2 abnormal nasal bone morphology 0.0302499707014558 0.114557002739297 0.872485649907074 0.615384615384615 23.2 23 2 abnormal ureter morphology 0.0302499707014558 0.114557002739297 0.872485649907074 0.615384615384615 23.2 23 2 abnormal erythrocyte osmotic lysis 0.0302499707014558 0.114557002739297 0.872485649907074 0.615384615384615 23.2 23 2 short premaxilla 0.116592764337198 0.305736737517484 0.872485649907074 0.615384615384615 23.2 23 2 absent myocardial trabeculae 0.116592764337198 0.305736737517484 0.872485649907074 0.615384615384615 23.2 23 2 abnormal renal/urinary system morphology 0.116592764337198 0.305736737517484 0.872485649907074 0.615384615384615 23.2 23 2 uterus hypoplasia 0.116592764337198 0.305736737517484 0.872485649907074 0.615384615384615 23.2 23 2 abnormal digestion 0.116592764337198 0.305736737517484 0.872485649907074 0.615384615384615 23.2 23 2 lymphoid hypoplasia 0.116592764337198 0.305736737517484 0.872485649907074 0.615384615384615 23.2 23 2 abnormal lung interstitium morphology 0.116592764337198 0.305736737517484 0.872485649907074 0.615384615384615 23.2 23 2 abnormal retinal inner plexiform layer morphology 0.116592764337198 0.305736737517484 0.872485649907074 0.615384615384615 23.2 23 2 small interparietal bone 0.116592764337198 0.305736737517484 0.872485649907074 0.615384615384615 23.2 23 2 abnormal vertebral arch development 0.116592764337198 0.305736737517484 0.872485649907074 0.615384615384615 23.2 23 2 increased circulating thyroxine level 0.116592764337198 0.305736737517484 0.872485649907074 0.615384615384615 23.2 23 2 decreased cardiac stroke volume 0.116592764337198 0.305736737517484 0.872485649907074 0.615384615384615 23.2 23 2 acanthosis 0.00870760040619917 0.0464312025946848 0.872485649907074 0.615384615384615 23.2 23 2 no abnormal phenotype detected 2.33285520110748e-67 2.90148865637743e-64 0.871919917136961 0.614985590778098 23.2 23 2 postnatal lethality 1.37567545351672e-07 3.30627313103656e-06 0.871171665494563 0.614457831325301 23.2 23 2 thick epidermis 0.000553387525517857 0.00490749187067975 0.870927639817954 0.614285714285714 23.2 23 2 abnormal craniofacial bone morphology 0.00177903533085111 0.0135746944340249 0.870572304183593 0.614035087719298 23.2 23 2 omphalocele 0.00584342435223154 0.0333383442114127 0.870006997492565 0.613636363636364 23.2 23 2 abnormal eyelid morphology 0.0198971475633813 0.0865282422445996 0.868967562609061 0.612903225806452 23.2 23 2 abnormal retinal photoreceptor layer morphology 0.0198971475633813 0.0865282422445996 0.868967562609061 0.612903225806452 23.2 23 2 abnormal CD8-positive, alpha beta T cell morphology 0.0198971475633813 0.0865282422445996 0.868967562609061 0.612903225806452 23.2 23 2 abnormal podocyte morphology 0.0198971475633813 0.0865282422445996 0.868967562609061 0.612903225806452 23.2 23 2 female infertility 4.09182135628908e-11 1.95738569687867e-09 0.86879562601179 0.612781954887218 23.2 23 2 abnormal retinal pigment epithelium morphology 0.000259149460185047 0.00270286910780002 0.868395873423135 0.6125 23.2 23 2 increased circulating LDL cholesterol level 0.00393741465046004 0.0247019393266566 0.868034192509589 0.612244897959184 23.2 23 2 abnormal respiratory system physiology 0.00393741465046004 0.0247019393266566 0.868034192509589 0.612244897959184 23.2 23 2 impaired limb coordination 0.00266209148756886 0.0183433589344253 0.866426721782719 0.611111111111111 23.2 23 2 abnormal neuronal precursor proliferation 0.00266209148756886 0.0183433589344253 0.866426721782719 0.611111111111111 23.2 23 2 abnormal limb bone morphology 0.0131978602138701 0.061767972308564 0.866426721782719 0.611111111111111 23.2 23 2 underdeveloped hair follicles 0.0728770880546532 0.216197682213417 0.866426721782719 0.611111111111111 23.2 23 2 abnormal retinal rod cell morphology 0.0728770880546532 0.216197682213417 0.866426721782719 0.611111111111111 23.2 23 2 abnormal thyroid cartilage morphology 0.0728770880546532 0.216197682213417 0.866426721782719 0.611111111111111 23.2 23 2 acidosis 0.0728770880546532 0.216197682213417 0.866426721782719 0.611111111111111 23.2 23 2 abnormal metacarpal bone morphology 0.0728770880546532 0.216197682213417 0.866426721782719 0.611111111111111 23.2 23 2 increased circulating renin level 0.0728770880546532 0.216197682213417 0.866426721782719 0.611111111111111 23.2 23 2 abnormal eye anterior chamber morphology 0.0728770880546532 0.216197682213417 0.866426721782719 0.611111111111111 23.2 23 2 atrioventricular block 0.0728770880546532 0.216197682213417 0.866426721782719 0.611111111111111 23.2 23 2 abnormal macrophage chemotaxis 0.0728770880546532 0.216197682213417 0.866426721782719 0.611111111111111 23.2 23 2 abnormal metanephric mesenchyme morphology 0.0728770880546532 0.216197682213417 0.866426721782719 0.611111111111111 23.2 23 2 increased bone trabecula number 0.00881056247912358 0.0468797308381174 0.864505598231095 0.609756097560976 23.2 23 2 lethality at weaning, incomplete penetrance 0.00881056247912358 0.0468797308381174 0.864505598231095 0.609756097560976 23.2 23 2 increased sensitivity to xenobiotic induced morbidity/mortality 2.72874486980837e-05 0.00039578733898824 0.863562501214842 0.609090909090909 23.2 23 2 abnormal forelimb morphology 0.0059116154520234 0.0334969098790619 0.863002110234171 0.608695652173913 23.2 23 2 delayed wound healing 0.0059116154520234 0.0334969098790619 0.863002110234171 0.608695652173913 23.2 23 2 fragile skeleton 0.0467069947714204 0.163122056418 0.863002110234171 0.608695652173913 23.2 23 2 abnormal blood vessel physiology 0.0467069947714204 0.163122056418 0.863002110234171 0.608695652173913 23.2 23 2 abnormal innervation pattern to muscle 0.0467069947714204 0.163122056418 0.863002110234171 0.608695652173913 23.2 23 2 abnormal circulating insulin level 0.0467069947714204 0.163122056418 0.863002110234171 0.608695652173913 23.2 23 2 abnormal palatal shelf fusion at midline 0.0467069947714204 0.163122056418 0.863002110234171 0.608695652173913 23.2 23 2 abnormal basicranium morphology 0.0467069947714204 0.163122056418 0.863002110234171 0.608695652173913 23.2 23 2 abnormal hepatocyte physiology 0.0467069947714204 0.163122056418 0.863002110234171 0.608695652173913 23.2 23 2 abnormal gait 3.42333715984948e-12 2.00365910238249e-10 0.862603126364437 0.608414239482201 23.2 23 2 increased kidney weight 0.00398284685930447 0.0249241045597984 0.861793423805272 0.607843137254902 23.2 23 2 enhanced long term potentiation 0.00269250649687821 0.0184282762269347 0.860800574238676 0.607142857142857 23.2 23 2 rib bifurcation 0.0304129168452148 0.114557002739297 0.860800574238676 0.607142857142857 23.2 23 2 abnormal circulating cholesterol level 0.0304129168452148 0.114557002739297 0.860800574238676 0.607142857142857 23.2 23 2 increased triglyceride level 0.0304129168452148 0.114557002739297 0.860800574238676 0.607142857142857 23.2 23 2 decreased neutrophil cell number 1.90598534407684e-05 0.000283900511580308 0.860367793658365 0.606837606837607 23.2 23 2 dextrocardia 0.0200224301475711 0.0866941601254712 0.859266170363027 0.606060606060606 23.2 23 2 abnormal epidermis stratum basale morphology 0.0200224301475711 0.0866941601254712 0.859266170363027 0.606060606060606 23.2 23 2 abnormal retinal outer nuclear layer morphology 0.0132893190653602 0.0619628513122465 0.858135556980971 0.605263157894737 23.2 23 2 hyporesponsive to tactile stimuli 0.0132893190653602 0.0619628513122465 0.858135556980971 0.605263157894737 23.2 23 2 abnormal retina morphology 1.70705316237676e-08 5.08538292384694e-07 0.857424885712249 0.604761904761905 23.2 23 2 abnormal intestinal mucosa morphology 0.00887568862504248 0.04702508084088 0.857267876943578 0.604651162790698 23.2 23 2 abnormal cranium morphology 6.32657699323062e-06 0.000104567177878147 0.857021818425512 0.604477611940298 23.2 23 2 abnormal osteoclast morphology 0.0059573765463803 0.0337178024098316 0.856580963580643 0.604166666666667 23.2 23 2 neonatal lethality, incomplete penetrance 4.3928106722559e-10 1.71815284635018e-08 0.856126543971316 0.603846153846154 23.2 23 2 increased circulating bilirubin level 0.00401475663572552 0.0250922289732845 0.856023656512601 0.60377358490566 23.2 23 2 hyperglycemia 0.000271963308475256 0.00280127838439834 0.853895756798258 0.602272727272727 23.2 23 2 enlarged liver 0.000128768956875798 0.00148292953809513 0.850673508659397 0.6 23.2 23 2 increased liver glycogen level 0.0465782983080951 0.163122056418 0.850673508659397 0.6 23.2 23 2 decreased insulin secretion 0.000273867181668644 0.00281506039008576 0.850673508659397 0.6 23.2 23 2 abnormal kidney development 0.00272921150622984 0.0184984022390919 0.850673508659397 0.6 23.2 23 2 epidermal hyperplasia 0.00272921150622984 0.0184984022390919 0.850673508659397 0.6 23.2 23 2 perinatal lethality 0.0133244070391555 0.0620682818537439 0.850673508659397 0.6 23.2 23 2 decreased circulating thyroxine level 0.020050592772859 0.0867406078651943 0.850673508659397 0.6 23.2 23 2 increased urine glucose level 0.0723941896610612 0.216197682213417 0.850673508659397 0.6 23.2 23 2 abnormal fibula morphology 0.0723941896610612 0.216197682213417 0.850673508659397 0.6 23.2 23 2 decreased paired-pulse facilitation 0.0723941896610612 0.216197682213417 0.850673508659397 0.6 23.2 23 2 abnormal circulating cytokine level 0.0723941896610612 0.216197682213417 0.850673508659397 0.6 23.2 23 2 abnormal heart electrocardiography waveform feature 0.0723941896610612 0.216197682213417 0.850673508659397 0.6 23.2 23 2 absent incisors 0.115020741730046 0.305736737517484 0.850673508659397 0.6 23.2 23 2 decreased chondrocyte number 0.115020741730046 0.305736737517484 0.850673508659397 0.6 23.2 23 2 vagina atresia 0.115020741730046 0.305736737517484 0.850673508659397 0.6 23.2 23 2 abnormal apical ectodermal ridge morphology 0.115020741730046 0.305736737517484 0.850673508659397 0.6 23.2 23 2 abnormal bronchus morphology 0.115020741730046 0.305736737517484 0.850673508659397 0.6 23.2 23 2 joint inflammation 0.115020741730046 0.305736737517484 0.850673508659397 0.6 23.2 23 2 dilated ureter 0.115020741730046 0.305736737517484 0.850673508659397 0.6 23.2 23 2 abnormal energy homeostasis 0.115020741730046 0.305736737517484 0.850673508659397 0.6 23.2 23 2 abnormal cerebral aqueduct morphology 0.115020741730046 0.305736737517484 0.850673508659397 0.6 23.2 23 2 absent chorion 0.115020741730046 0.305736737517484 0.850673508659397 0.6 23.2 23 2 abnormal secondary palate development 0.115020741730046 0.305736737517484 0.850673508659397 0.6 23.2 23 2 abnormal aorta wall morphology 0.115020741730046 0.305736737517484 0.850673508659397 0.6 23.2 23 2 abnormal microglial cell activation 0.115020741730046 0.305736737517484 0.850673508659397 0.6 23.2 23 2 kidney hemorrhage 0.189842910945412 0.4070853915146 0.850673508659397 0.6 23.2 23 2 fused cornea and lens 0.189842910945412 0.4070853915146 0.850673508659397 0.6 23.2 23 2 rhinitis 0.189842910945412 0.4070853915146 0.850673508659397 0.6 23.2 23 2 abnormal gland morphology 0.189842910945412 0.4070853915146 0.850673508659397 0.6 23.2 23 2 abnormal airway responsiveness 0.189842910945412 0.4070853915146 0.850673508659397 0.6 23.2 23 2 acrania 0.189842910945412 0.4070853915146 0.850673508659397 0.6 23.2 23 2 intestinal hypoperistalsis 0.189842910945412 0.4070853915146 0.850673508659397 0.6 23.2 23 2 abnormal hypaxial muscle morphology 0.189842910945412 0.4070853915146 0.850673508659397 0.6 23.2 23 2 abnormal glial cell physiology 0.189842910945412 0.4070853915146 0.850673508659397 0.6 23.2 23 2 absent CD4-positive, alpha beta T cells 0.189842910945412 0.4070853915146 0.850673508659397 0.6 23.2 23 2 abnormal submandibular gland morphology 0.189842910945412 0.4070853915146 0.850673508659397 0.6 23.2 23 2 increased left ventricle diastolic pressure 0.189842910945412 0.4070853915146 0.850673508659397 0.6 23.2 23 2 abnormal pillar cell morphology 0.189842910945412 0.4070853915146 0.850673508659397 0.6 23.2 23 2 absent pharyngeal arches 0.189842910945412 0.4070853915146 0.850673508659397 0.6 23.2 23 2 abnormal corneal endothelium morphology 0.189842910945412 0.4070853915146 0.850673508659397 0.6 23.2 23 2 tachypnea 0.189842910945412 0.4070853915146 0.850673508659397 0.6 23.2 23 2 decreased thyroxine level 0.189842910945412 0.4070853915146 0.850673508659397 0.6 23.2 23 2 abnormal spinal cord dorsal column morphology 0.189842910945412 0.4070853915146 0.850673508659397 0.6 23.2 23 2 abnormal retinal blood vessel pattern 0.189842910945412 0.4070853915146 0.850673508659397 0.6 23.2 23 2 sinus bradycardia 0.189842910945412 0.4070853915146 0.850673508659397 0.6 23.2 23 2 decreased circulating lactate level 0.189842910945412 0.4070853915146 0.850673508659397 0.6 23.2 23 2 increased circulating triglyceride level 4.48946408079725e-06 7.65876082385089e-05 0.850673508659397 0.6 23.2 23 2 maternal effect 0.00185755315396863 0.0140185011154293 0.846441302148654 0.597014925373134 23.2 23 2 neonatal lethality, complete penetrance 1.93728300441978e-15 2.09521368412792e-13 0.845698809778348 0.596491228070175 23.2 23 2 abnormal blood homeostasis 6.14383083560593e-05 0.000787772123895347 0.845698809778348 0.596491228070175 23.2 23 2 eyelids open at birth 0.00599065404740051 0.0337525525320697 0.845220473347478 0.596153846153846 23.2 23 2 increased susceptibility to injury 0.00599065404740051 0.0337525525320697 0.845220473347478 0.596153846153846 23.2 23 2 postnatal lethality, complete penetrance 3.24196232437462e-13 2.30410893768053e-11 0.844796662312873 0.595854922279793 23.2 23 2 increased white adipose tissue amount 0.0199972074625552 0.0866941601254712 0.843009783356159 0.594594594594595 23.2 23 2 abnormal long bone metaphysis morphology 0.0199972074625552 0.0866941601254712 0.843009783356159 0.594594594594595 23.2 23 2 abnormal breathing pattern 0.0199972074625552 0.0866941601254712 0.843009783356159 0.594594594594595 23.2 23 2 decreased litter size 6.96092835202706e-10 2.62353170843444e-08 0.842600687699403 0.594306049822064 23.2 23 2 abnormal coat appearance 0.00185974085149414 0.0140185011154293 0.842454440942881 0.594202898550725 23.2 23 2 abnormal food intake 0.00185974085149414 0.0140185011154293 0.842454440942881 0.594202898550725 23.2 23 2 abnormal urine homeostasis 0.000276836586027294 0.0028338724598473 0.841812326277528 0.59375 23.2 23 2 abnormal tooth morphology 0.00273807084272269 0.0185332006021025 0.841812326277528 0.59375 23.2 23 2 small ovary 0.000404004412009993 0.00382114439115915 0.841325448124678 0.593406593406593 23.2 23 2 increased hemoglobin content 0.0040412896760336 0.0252263690567969 0.841061378618048 0.593220338983051 23.2 23 2 increased exploration in new environment 0.000863732835315804 0.00717962291352004 0.840171366577182 0.592592592592593 23.2 23 2 abnormal maxilla morphology 0.00598226957849879 0.0337525525320697 0.840171366577182 0.592592592592593 23.2 23 2 abnormal mandible morphology 0.00598226957849879 0.0337525525320697 0.840171366577182 0.592592592592593 23.2 23 2 abnormal motor capabilities/coordination/movement 2.93688547518636e-05 0.000421066433402079 0.837784516103952 0.590909090909091 23.2 23 2 decreased macrophage cell number 0.0132556259079917 0.0619218205561113 0.837784516103952 0.590909090909091 23.2 23 2 lethality, incomplete penetrance 0.0132556259079917 0.0619218205561113 0.837784516103952 0.590909090909091 23.2 23 2 abnormal abdominal fat pad morphology 0.0714845222479161 0.216197682213417 0.837784516103952 0.590909090909091 23.2 23 2 abnormal circulating lipid level 0.0714845222479161 0.216197682213417 0.837784516103952 0.590909090909091 23.2 23 2 abnormal cerebral cortex pyramidal cell morphology 0.0714845222479161 0.216197682213417 0.837784516103952 0.590909090909091 23.2 23 2 decreased heart rate 0.000276771948414958 0.0028338724598473 0.836495616848407 0.59 23.2 23 2 abnormal circulating hormone level 0.0198755396379042 0.0865282422445996 0.836132081160946 0.58974358974359 23.2 23 2 respiratory distress 2.20752729221744e-06 4.00819280247509e-05 0.835921944925419 0.589595375722543 23.2 23 2 abnormal neuron differentiation 0.000130469687091445 0.00148873094788977 0.835482910290479 0.589285714285714 23.2 23 2 abnormal spatial learning 4.6111279033939e-06 7.79209874153909e-05 0.835016941015359 0.588957055214724 23.2 23 2 abnormal cervical vertebrae morphology 0.00884038938357964 0.0468879927327385 0.833993635940585 0.588235294117647 23.2 23 2 abnormal gluconeogenesis 0.00884038938357964 0.0468879927327385 0.833993635940585 0.588235294117647 23.2 23 2 abnormal response to novel object 0.00884038938357964 0.0468879927327385 0.833993635940585 0.588235294117647 23.2 23 2 decreased susceptibility to injury 0.0027238301998554 0.0184984022390919 0.833993635940585 0.588235294117647 23.2 23 2 short maxilla 0.0299955897191829 0.114557002739297 0.833993635940585 0.588235294117647 23.2 23 2 abnormal oocyte morphology 0.0299955897191829 0.114557002739297 0.833993635940585 0.588235294117647 23.2 23 2 impaired synaptic plasticity 0.0299955897191829 0.114557002739297 0.833993635940585 0.588235294117647 23.2 23 2 hydroureter 0.11270531522319 0.305736737517484 0.833993635940585 0.588235294117647 23.2 23 2 abnormal glutamate-mediated receptor currents 0.11270531522319 0.305736737517484 0.833993635940585 0.588235294117647 23.2 23 2 decreased vasoconstriction 0.11270531522319 0.305736737517484 0.833993635940585 0.588235294117647 23.2 23 2 absence seizures 0.11270531522319 0.305736737517484 0.833993635940585 0.588235294117647 23.2 23 2 aminoaciduria 0.11270531522319 0.305736737517484 0.833993635940585 0.588235294117647 23.2 23 2 increased regulatory T cell number 0.11270531522319 0.305736737517484 0.833993635940585 0.588235294117647 23.2 23 2 abnormal melanosome morphology 0.11270531522319 0.305736737517484 0.833993635940585 0.588235294117647 23.2 23 2 coloboma 0.11270531522319 0.305736737517484 0.833993635940585 0.588235294117647 23.2 23 2 increased hepatoma incidence 0.11270531522319 0.305736737517484 0.833993635940585 0.588235294117647 23.2 23 2 decreased granulocyte number 0.0456512128541117 0.163040045907542 0.831117795816652 0.586206896551724 23.2 23 2 increased retinal apoptosis 0.0456512128541117 0.163040045907542 0.831117795816652 0.586206896551724 23.2 23 2 abnormal cholesterol homeostasis 0.0196968934768475 0.0860334021486533 0.829925374301851 0.585365853658537 23.2 23 2 increased bone mineral density 0.000187605957948499 0.00203785947771568 0.828089256217112 0.584070796460177 23.2 23 2 abnormal kidney physiology 0.0130430676354313 0.0611009995162625 0.827043688974414 0.583333333333333 23.2 23 2 abnormal startle reflex 0.0702715555330703 0.214474052651097 0.827043688974414 0.583333333333333 23.2 23 2 small lymph nodes 0.0702715555330703 0.214474052651097 0.827043688974414 0.583333333333333 23.2 23 2 abnormal impulse conducting system conduction 0.0702715555330703 0.214474052651097 0.827043688974414 0.583333333333333 23.2 23 2 abnormal supraoccipital bone morphology 0.183269850457293 0.4070853915146 0.827043688974414 0.583333333333333 23.2 23 2 abnormal rectum morphology 0.183269850457293 0.4070853915146 0.827043688974414 0.583333333333333 23.2 23 2 amyloidosis 0.183269850457293 0.4070853915146 0.827043688974414 0.583333333333333 23.2 23 2 absent optic nerve 0.183269850457293 0.4070853915146 0.827043688974414 0.583333333333333 23.2 23 2 impaired embryo implantation 0.183269850457293 0.4070853915146 0.827043688974414 0.583333333333333 23.2 23 2 increased papilloma incidence 0.183269850457293 0.4070853915146 0.827043688974414 0.583333333333333 23.2 23 2 abnormal AMPA-mediated synaptic currents 0.183269850457293 0.4070853915146 0.827043688974414 0.583333333333333 23.2 23 2 abnormal gastrocnemius morphology 0.183269850457293 0.4070853915146 0.827043688974414 0.583333333333333 23.2 23 2 abnormal aorta elastic fiber morphology 0.183269850457293 0.4070853915146 0.827043688974414 0.583333333333333 23.2 23 2 decreased left ventricle systolic pressure 0.183269850457293 0.4070853915146 0.827043688974414 0.583333333333333 23.2 23 2 increased hepatocyte proliferation 0.183269850457293 0.4070853915146 0.827043688974414 0.583333333333333 23.2 23 2 vestibular saccular macula degeneration 0.183269850457293 0.4070853915146 0.827043688974414 0.583333333333333 23.2 23 2 bowed ulna 0.183269850457293 0.4070853915146 0.827043688974414 0.583333333333333 23.2 23 2 stria vascularis degeneration 0.183269850457293 0.4070853915146 0.827043688974414 0.583333333333333 23.2 23 2 small parietal bone 0.183269850457293 0.4070853915146 0.827043688974414 0.583333333333333 23.2 23 2 abnormal palatine bone morphology 0.183269850457293 0.4070853915146 0.827043688974414 0.583333333333333 23.2 23 2 decreased renal glomerular filtration rate 0.183269850457293 0.4070853915146 0.827043688974414 0.583333333333333 23.2 23 2 decreased keratinocyte proliferation 0.183269850457293 0.4070853915146 0.827043688974414 0.583333333333333 23.2 23 2 hydrometra 0.183269850457293 0.4070853915146 0.827043688974414 0.583333333333333 23.2 23 2 abnormal epidermis stratum granulosum morphology 0.0296444183554434 0.114415035933538 0.827043688974414 0.583333333333333 23.2 23 2 increased thermal nociceptive threshold 0.000846700906792884 0.00717600297405005 0.825745347233481 0.582417582417582 23.2 23 2 abnormal locomotor activation 0.000846700906792884 0.00717600297405005 0.825745347233481 0.582417582417582 23.2 23 2 rib fusion 0.00395371824420509 0.024772982701411 0.825280269594937 0.582089552238806 23.2 23 2 increased circulating calcium level 0.00869238662839013 0.046399810596825 0.824895523548506 0.581818181818182 23.2 23 2 abnormal contextual conditioning behavior 0.00869238662839013 0.046399810596825 0.824895523548506 0.581818181818182 23.2 23 2 abnormal joint morphology 0.00869238662839013 0.046399810596825 0.824895523548506 0.581818181818182 23.2 23 2 decreased neuronal precursor cell number 0.0449521499472147 0.160889889199563 0.8232324277349 0.580645161290323 23.2 23 2 small cranium 0.0449521499472147 0.160889889199563 0.8232324277349 0.580645161290323 23.2 23 2 abnormal intestine physiology 0.0449521499472147 0.160889889199563 0.8232324277349 0.580645161290323 23.2 23 2 increased body weight 3.37320380814932e-07 7.52405521706625e-06 0.822824078316381 0.580357142857143 23.2 23 2 abnormal hindlimb morphology 0.0128956539694118 0.0606388265574892 0.822317725037417 0.58 23.2 23 2 increased circulating chloride level 0.0128956539694118 0.0606388265574892 0.822317725037417 0.58 23.2 23 2 abnormal trabecular bone morphology 0.000183839583327838 0.00200570598038595 0.822079441141434 0.579831932773109 23.2 23 2 impaired righting response 0.000832666184539092 0.00710551332432587 0.820825315373102 0.578947368421053 23.2 23 2 increased grooming behavior 0.0292205540086984 0.113004200373903 0.820825315373102 0.578947368421053 23.2 23 2 decreased threshold for auditory brainstem response 0.0292205540086984 0.113004200373903 0.820825315373102 0.578947368421053 23.2 23 2 stereotypic behavior 0.109934571672379 0.301675556233449 0.820825315373102 0.578947368421053 23.2 23 2 altered susceptibility to infection 0.109934571672379 0.301675556233449 0.820825315373102 0.578947368421053 23.2 23 2 abnormal long term depression 0.109934571672379 0.301675556233449 0.820825315373102 0.578947368421053 23.2 23 2 delayed sexual maturation 0.109934571672379 0.301675556233449 0.820825315373102 0.578947368421053 23.2 23 2 abnormal neurotransmitter level 0.109934571672379 0.301675556233449 0.820825315373102 0.578947368421053 23.2 23 2 abnormal nasal septum morphology 0.109934571672379 0.301675556233449 0.820825315373102 0.578947368421053 23.2 23 2 abnormal neural crest cell migration 0.109934571672379 0.301675556233449 0.820825315373102 0.578947368421053 23.2 23 2 increased susceptibility to ischemic brain injury 0.109934571672379 0.301675556233449 0.820825315373102 0.578947368421053 23.2 23 2 osteoarthritis 0.109934571672379 0.301675556233449 0.820825315373102 0.578947368421053 23.2 23 2 abnormal cochlear inner hair cell morphology 0.109934571672379 0.301675556233449 0.820825315373102 0.578947368421053 23.2 23 2 eyelids fail to open 0.109934571672379 0.301675556233449 0.820825315373102 0.578947368421053 23.2 23 2 decreased liver regeneration 0.109934571672379 0.301675556233449 0.820825315373102 0.578947368421053 23.2 23 2 decreased fertilization frequency 0.109934571672379 0.301675556233449 0.820825315373102 0.578947368421053 23.2 23 2 decreased circulating magnesium level 0.109934571672379 0.301675556233449 0.820825315373102 0.578947368421053 23.2 23 2 abnormal circulating amino acid level 0.00859526567538815 0.0460295443864974 0.820825315373102 0.578947368421053 23.2 23 2 increased susceptibility to parasitic infection 0.00121291440436064 0.00968579319694088 0.819167082412753 0.577777777777778 23.2 23 2 abnormal autopod morphology 0.0192058141170563 0.0852354373169984 0.819167082412753 0.577777777777778 23.2 23 2 irregular heartbeat 0.0192058141170563 0.0852354373169984 0.819167082412753 0.577777777777778 23.2 23 2 abnormal metabolism 0.0192058141170563 0.0852354373169984 0.819167082412753 0.577777777777778 23.2 23 2 abnormal snout morphology 0.012726392114733 0.0602414850340597 0.817955296787882 0.576923076923077 23.2 23 2 absent corpus luteum 0.012726392114733 0.0602414850340597 0.817955296787882 0.576923076923077 23.2 23 2 abnormal female meiosis 0.012726392114733 0.0602414850340597 0.817955296787882 0.576923076923077 23.2 23 2 abnormal kidney cortex morphology 0.0688441995898759 0.214474052651097 0.817955296787882 0.576923076923077 23.2 23 2 abnormal colon morphology 0.00848559474916119 0.0455402738695544 0.817031053514675 0.576271186440678 23.2 23 2 increased sensitivity to induced morbidity/mortality 6.18491770398135e-06 0.000102566551924357 0.816769854328769 0.576086956521739 23.2 23 2 deafness 0.000815532371740308 0.00698325912118422 0.816302861844876 0.575757575757576 23.2 23 2 abnormal tail morphology 0.00568589825871588 0.0325141883185189 0.816302861844876 0.575757575757576 23.2 23 2 decreased circulating phosphate level 0.0287388366832701 0.113004200373903 0.815228779131922 0.575 23.2 23 2 increased total body fat amount 0.000121059564915466 0.00141378247759259 0.814699753318079 0.574626865671642 23.2 23 2 abnormal tibia morphology 0.0189086392166997 0.0841417532227916 0.814474635950487 0.574468085106383 23.2 23 2 hyperactivity 2.83150166367517e-10 1.15464924399869e-08 0.813986780523143 0.574123989218329 23.2 23 2 abnormal osteoblast physiology 0.0125388170413429 0.0595234873861459 0.813916011371645 0.574074074074074 23.2 23 2 abnormal nervous system physiology 0.000374373024701507 0.00358864315585741 0.813687703935076 0.573913043478261 23.2 23 2 increased startle reflex 0.00172499857920467 0.013243623351147 0.812440991416278 0.573033707865168 23.2 23 2 decreased startle reflex 0.000369776996071377 0.00355142964373572 0.811896368663527 0.572649572649573 23.2 23 2 abnormal intestinal goblet cell morphology 0.043255585647615 0.15593952072238 0.810165246342283 0.571428571428571 23.2 23 2 decreased bone volume 0.043255585647615 0.15593952072238 0.810165246342283 0.571428571428571 23.2 23 2 decreased cochlear outer hair cell number 0.106891342130693 0.301465094728002 0.810165246342283 0.571428571428571 23.2 23 2 myoclonus 0.0672675213059761 0.214474052651097 0.810165246342283 0.571428571428571 23.2 23 2 reddish skin 0.0672675213059761 0.214474052651097 0.810165246342283 0.571428571428571 23.2 23 2 absent corpus callosum 0.0672675213059761 0.214474052651097 0.810165246342283 0.571428571428571 23.2 23 2 corneal vascularization 0.0672675213059761 0.214474052651097 0.810165246342283 0.571428571428571 23.2 23 2 abnormal interparietal bone morphology 0.176337551794202 0.400584164463998 0.810165246342283 0.571428571428571 23.2 23 2 megacephaly 0.176337551794202 0.400584164463998 0.810165246342283 0.571428571428571 23.2 23 2 abnormal kidney blood vessel morphology 0.176337551794202 0.400584164463998 0.810165246342283 0.571428571428571 23.2 23 2 extended life span 0.176337551794202 0.400584164463998 0.810165246342283 0.571428571428571 23.2 23 2 abnormal fluid regulation 0.176337551794202 0.400584164463998 0.810165246342283 0.571428571428571 23.2 23 2 absent otoliths 0.176337551794202 0.400584164463998 0.810165246342283 0.571428571428571 23.2 23 2 decreased coping response 0.176337551794202 0.400584164463998 0.810165246342283 0.571428571428571 23.2 23 2 abnormal voluntary movement 0.176337551794202 0.400584164463998 0.810165246342283 0.571428571428571 23.2 23 2 abnormal pancreas development 0.176337551794202 0.400584164463998 0.810165246342283 0.571428571428571 23.2 23 2 decreased CNS synapse formation 0.176337551794202 0.400584164463998 0.810165246342283 0.571428571428571 23.2 23 2 increased circulating growth hormone level 0.176337551794202 0.400584164463998 0.810165246342283 0.571428571428571 23.2 23 2 decreased tongue size 0.176337551794202 0.400584164463998 0.810165246342283 0.571428571428571 23.2 23 2 sternebra fusion 0.176337551794202 0.400584164463998 0.810165246342283 0.571428571428571 23.2 23 2 abnormal heart left ventricle morphology 0.00543581821199207 0.0311916904321344 0.807352172570261 0.569444444444444 23.2 23 2 abnormal vertebrae morphology 0.000762813520947345 0.00656573921576651 0.806448892001263 0.568807339449541 23.2 23 2 short femur 0.00243514756217293 0.0170631818617047 0.805562034715338 0.568181818181818 23.2 23 2 hypertension 0.0276489128223933 0.113004200373903 0.805562034715338 0.568181818181818 23.2 23 2 abnormal photoreceptor outer segment morphology 0.0276489128223933 0.113004200373903 0.805562034715338 0.568181818181818 23.2 23 2 small seminiferous tubules 0.00534368743104252 0.0306984352995803 0.80469115683997 0.567567567567568 23.2 23 2 increased brown adipose tissue amount 0.0423063826523593 0.153855448607813 0.80469115683997 0.567567567567568 23.2 23 2 decreased circulating chloride level 0.0423063826523593 0.153855448607813 0.80469115683997 0.567567567567568 23.2 23 2 increased insulin secretion 0.0423063826523593 0.153855448607813 0.80469115683997 0.567567567567568 23.2 23 2 gastrointestinal hemorrhage 0.0655897659096644 0.214254159816533 0.80341386928943 0.566666666666667 23.2 23 2 delayed eyelid opening 0.0655897659096644 0.214254159816533 0.80341386928943 0.566666666666667 23.2 23 2 abnormal sleep pattern 0.0270593986694527 0.111348642167516 0.801359102360302 0.565217391304348 23.2 23 2 blistering 0.103695307967361 0.292783290089455 0.801359102360302 0.565217391304348 23.2 23 2 conjunctivitis 0.103695307967361 0.292783290089455 0.801359102360302 0.565217391304348 23.2 23 2 abnormal cardiovascular development 0.103695307967361 0.292783290089455 0.801359102360302 0.565217391304348 23.2 23 2 abnormal epidermal layer morphology 0.00780734206266586 0.0426829964414974 0.801359102360302 0.565217391304348 23.2 23 2 circling 0.0034765163340975 0.0226087173361243 0.800633890502962 0.564705882352941 23.2 23 2 increased vascular permeability 0.0413141020179617 0.150577038490373 0.799778512414818 0.564102564102564 23.2 23 2 abnormal response to injury 0.0413141020179617 0.150577038490373 0.799778512414818 0.564102564102564 23.2 23 2 increased circulating insulin level 0.000100017397423964 0.00119325312274393 0.797506414368185 0.5625 23.2 23 2 abnormal crypts of Lieberkuhn morphology 0.0638470799012105 0.21161840273719 0.797506414368185 0.5625 23.2 23 2 abnormal lymphatic vessel morphology 0.0638470799012105 0.21161840273719 0.797506414368185 0.5625 23.2 23 2 failure of tooth eruption 0.16935812545432 0.391272038095932 0.797506414368185 0.5625 23.2 23 2 mixed cellular infiltration to dermis 0.16935812545432 0.391272038095932 0.797506414368185 0.5625 23.2 23 2 disorganized retinal layers 0.16935812545432 0.391272038095932 0.797506414368185 0.5625 23.2 23 2 reduced male mating frequency 0.16935812545432 0.391272038095932 0.797506414368185 0.5625 23.2 23 2 paternal imprinting 0.16935812545432 0.391272038095932 0.797506414368185 0.5625 23.2 23 2 impaired muscle relaxation 0.16935812545432 0.391272038095932 0.797506414368185 0.5625 23.2 23 2 bowed tibia 0.16935812545432 0.391272038095932 0.797506414368185 0.5625 23.2 23 2 small epididymis 0.16935812545432 0.391272038095932 0.797506414368185 0.5625 23.2 23 2 abnormal wound healing 0.16935812545432 0.391272038095932 0.797506414368185 0.5625 23.2 23 2 embryonic lethality between somite formation and embryo turning, incomplete penetrance 0.16935812545432 0.391272038095932 0.797506414368185 0.5625 23.2 23 2 abnormal response/metabolism to endogenous compounds 0.00494874090185969 0.0294546243738829 0.795345150372607 0.560975609756098 23.2 23 2 palatal shelves fail to meet at midline 0.0402924307803657 0.147068850427233 0.795345150372607 0.560975609756098 23.2 23 2 impaired swimming 0.0111774875984567 0.0558874379922835 0.7948212075858 0.560606060606061 23.2 23 2 abnormal axon extension 0.0258268860587493 0.107252719651317 0.793961941415437 0.56 23.2 23 2 abnormal nest building behavior 0.100426610183039 0.284199309249499 0.793961941415437 0.56 23.2 23 2 decreased exploration in new environment 0.00484595693019578 0.0292193431043527 0.793286803710152 0.55952380952381 23.2 23 2 increased food intake 0.00484595693019578 0.0292193431043527 0.793286803710152 0.55952380952381 23.2 23 2 abnormal thoracic vertebrae morphology 0.0167345242900807 0.0751392223313643 0.793000728411302 0.559322033898305 23.2 23 2 abnormal retinal photoreceptor morphology 0.0620667617156545 0.205992087748753 0.792293954143556 0.558823529411765 23.2 23 2 thin skin 0.0620667617156545 0.205992087748753 0.792293954143556 0.558823529411765 23.2 23 2 obese 0.00718215567467172 0.0397013605349909 0.791752399834504 0.558441558441558 23.2 23 2 abnormal maternal nurturing 0.0163404938066996 0.0734362752378776 0.790243150120751 0.557377049180328 23.2 23 2 dehydration 0.0106798439902848 0.0539961624508812 0.789911115183726 0.557142857142857 23.2 23 2 abnormal suckling behavior 0.00463840165330424 0.028418778602449 0.789450794021031 0.556818181818182 23.2 23 2 increased susceptibility to bacterial infection induced morbidity/mortality 0.0104289181681196 0.0534539155971762 0.787660656166108 0.555555555555556 23.2 23 2 abnormal ovarian follicle morphology 0.0382027862040645 0.140993220597345 0.787660656166108 0.555555555555556 23.2 23 2 head tilt 0.0602695447628291 0.200294579288627 0.787660656166108 0.555555555555556 23.2 23 2 wrinkled skin 0.0971397649167226 0.27748705936172 0.787660656166108 0.555555555555556 23.2 23 2 right pulmonary isomerism 0.16249059918386 0.391272038095932 0.787660656166108 0.555555555555556 23.2 23 2 abnormal radius morphology 0.16249059918386 0.391272038095932 0.787660656166108 0.555555555555556 23.2 23 2 absent spleen 0.16249059918386 0.391272038095932 0.787660656166108 0.555555555555556 23.2 23 2 thick dermal layer 0.16249059918386 0.391272038095932 0.787660656166108 0.555555555555556 23.2 23 2 blepharoptosis 0.16249059918386 0.391272038095932 0.787660656166108 0.555555555555556 23.2 23 2 abnormal iron level 0.16249059918386 0.391272038095932 0.787660656166108 0.555555555555556 23.2 23 2 eye inflammation 0.16249059918386 0.391272038095932 0.787660656166108 0.555555555555556 23.2 23 2 abnormal white adipose tissue morphology 0.16249059918386 0.391272038095932 0.787660656166108 0.555555555555556 23.2 23 2 decreased activity of thyroid 0.16249059918386 0.391272038095932 0.787660656166108 0.555555555555556 23.2 23 2 absent ureter 0.16249059918386 0.391272038095932 0.787660656166108 0.555555555555556 23.2 23 2 jerky movement 0.16249059918386 0.391272038095932 0.787660656166108 0.555555555555556 23.2 23 2 abnormal glycogen homeostasis 0.16249059918386 0.391272038095932 0.787660656166108 0.555555555555556 23.2 23 2 abnormal pregnancy 0.16249059918386 0.391272038095932 0.787660656166108 0.555555555555556 23.2 23 2 crypts of Lieberkuhn abscesses 0.295595933601262 0.582873471924803 0.787660656166108 0.555555555555556 23.2 23 2 renal tubular acidosis 0.295595933601262 0.582873471924803 0.787660656166108 0.555555555555556 23.2 23 2 synostosis 0.295595933601262 0.582873471924803 0.787660656166108 0.555555555555556 23.2 23 2 thick tail 0.295595933601262 0.582873471924803 0.787660656166108 0.555555555555556 23.2 23 2 absent parathyroid glands 0.295595933601262 0.582873471924803 0.787660656166108 0.555555555555556 23.2 23 2 small nodose ganglion 0.295595933601262 0.582873471924803 0.787660656166108 0.555555555555556 23.2 23 2 abnormal kindling response 0.295595933601262 0.582873471924803 0.787660656166108 0.555555555555556 23.2 23 2 abnormal ion homeostasis 0.295595933601262 0.582873471924803 0.787660656166108 0.555555555555556 23.2 23 2 polycythemia 0.295595933601262 0.582873471924803 0.787660656166108 0.555555555555556 23.2 23 2 abnormal abdominal wall morphology 0.295595933601262 0.582873471924803 0.787660656166108 0.555555555555556 23.2 23 2 decreased susceptibility to induced choroidal neovascularization 0.295595933601262 0.582873471924803 0.787660656166108 0.555555555555556 23.2 23 2 decreased muscle weight 0.295595933601262 0.582873471924803 0.787660656166108 0.555555555555556 23.2 23 2 abnormal proprioceptive neuron morphology 0.295595933601262 0.582873471924803 0.787660656166108 0.555555555555556 23.2 23 2 small scapula 0.295595933601262 0.582873471924803 0.787660656166108 0.555555555555556 23.2 23 2 abnormal stria vascularis vasculature morphology 0.295595933601262 0.582873471924803 0.787660656166108 0.555555555555556 23.2 23 2 abnormal hair cell mechanoelectric transduction 0.295595933601262 0.582873471924803 0.787660656166108 0.555555555555556 23.2 23 2 abnormal gallbladder physiology 0.295595933601262 0.582873471924803 0.787660656166108 0.555555555555556 23.2 23 2 abnormal intervertebral disk development 0.295595933601262 0.582873471924803 0.787660656166108 0.555555555555556 23.2 23 2 enhanced conditioned place preference behavior 0.295595933601262 0.582873471924803 0.787660656166108 0.555555555555556 23.2 23 2 abnormal optic chiasm morphology 0.295595933601262 0.582873471924803 0.787660656166108 0.555555555555556 23.2 23 2 multiflagellated sperm 0.295595933601262 0.582873471924803 0.787660656166108 0.555555555555556 23.2 23 2 eye opacity 0.295595933601262 0.582873471924803 0.787660656166108 0.555555555555556 23.2 23 2 abnormal heart left ventricle pressure 0.295595933601262 0.582873471924803 0.787660656166108 0.555555555555556 23.2 23 2 abnormal pulmonary alveolar parenchyma morphology 0.295595933601262 0.582873471924803 0.787660656166108 0.555555555555556 23.2 23 2 decreased bone trabecular spacing 0.295595933601262 0.582873471924803 0.787660656166108 0.555555555555556 23.2 23 2 abnormal coronary sinus connection 0.295595933601262 0.582873471924803 0.787660656166108 0.555555555555556 23.2 23 2 enhanced leukocyte tethering or rolling 0.295595933601262 0.582873471924803 0.787660656166108 0.555555555555556 23.2 23 2 reduced long term potentiation 0.00191295290990716 0.0141621141767681 0.784847582394086 0.553571428571429 23.2 23 2 short mandible 0.0239192873903561 0.100251436197996 0.784847582394086 0.553571428571429 23.2 23 2 abnormal innervation 0.0371508151347661 0.137212550330706 0.784308908693061 0.553191489361702 23.2 23 2 abnormal femur morphology 0.0151510855997667 0.0701831013583235 0.782958204487505 0.552238805970149 23.2 23 2 abnormal circulating glucose level 0.0938722086313479 0.276339785763879 0.78222851370979 0.551724137931034 23.2 23 2 polychromatophilia 0.0938722086313479 0.276339785763879 0.78222851370979 0.551724137931034 23.2 23 2 absent gastric milk in neonates 0.00967832303759432 0.0509520181079701 0.781601728041754 0.551282051282051 23.2 23 2 waved hair 0.155817260797323 0.391272038095932 0.779784049604447 0.55 23.2 23 2 anencephaly 0.155817260797323 0.391272038095932 0.779784049604447 0.55 23.2 23 2 decreased skin tensile strength 0.155817260797323 0.391272038095932 0.779784049604447 0.55 23.2 23 2 abnormal heart right ventricle morphology 0.155817260797323 0.391272038095932 0.779784049604447 0.55 23.2 23 2 decreased circulating VLDL cholesterol level 0.155817260797323 0.391272038095932 0.779784049604447 0.55 23.2 23 2 abnormal thrombosis 0.0350615977649473 0.131547095686737 0.778394060211213 0.549019607843137 23.2 23 2 abnormal cranial ganglia morphology 0.0906497281497819 0.267169666792159 0.777497292860739 0.548387096774194 23.2 23 2 absent mature ovarian follicles 0.0906497281497819 0.267169666792159 0.777497292860739 0.548387096774194 23.2 23 2 abnormal eye electrophysiology 0.00229500652035131 0.0162182634073122 0.773339553326725 0.545454545454545 23.2 23 2 increased liver weight 0.00847060312927634 0.0455089099008097 0.773339553326725 0.545454545454545 23.2 23 2 abnormal gametogenesis 0.0531765226011484 0.181698626332908 0.773339553326725 0.545454545454545 23.2 23 2 abnormal amino acid level 0.0531765226011484 0.181698626332908 0.773339553326725 0.545454545454545 23.2 23 2 abnormal facial nerve morphology 0.149379525990025 0.386259429210173 0.773339553326725 0.545454545454545 23.2 23 2 abnormal tracheal cartilage morphology 0.149379525990025 0.386259429210173 0.773339553326725 0.545454545454545 23.2 23 2 abnormal blood-brain barrier function 0.149379525990025 0.386259429210173 0.773339553326725 0.545454545454545 23.2 23 2 cleft upper lip 0.149379525990025 0.386259429210173 0.773339553326725 0.545454545454545 23.2 23 2 increased bone volume 0.149379525990025 0.386259429210173 0.773339553326725 0.545454545454545 23.2 23 2 abnormal awl hair morphology 0.277316632462835 0.555191246077507 0.773339553326725 0.545454545454545 23.2 23 2 abnormal sebaceous gland morphology 0.277316632462835 0.555191246077507 0.773339553326725 0.545454545454545 23.2 23 2 abnormal glossopharyngeal ganglion morphology 0.277316632462835 0.555191246077507 0.773339553326725 0.545454545454545 23.2 23 2 abnormal fear/anxiety-related behavior 0.277316632462835 0.555191246077507 0.773339553326725 0.545454545454545 23.2 23 2 abnormal larynx morphology 0.277316632462835 0.555191246077507 0.773339553326725 0.545454545454545 23.2 23 2 abnormal bronchiole morphology 0.277316632462835 0.555191246077507 0.773339553326725 0.545454545454545 23.2 23 2 decreased post-tetanic potentiation 0.277316632462835 0.555191246077507 0.773339553326725 0.545454545454545 23.2 23 2 patent ductus arteriosus 0.277316632462835 0.555191246077507 0.773339553326725 0.545454545454545 23.2 23 2 rectal hemorrhage 0.277316632462835 0.555191246077507 0.773339553326725 0.545454545454545 23.2 23 2 impaired luteinization 0.277316632462835 0.555191246077507 0.773339553326725 0.545454545454545 23.2 23 2 abnormal nerve fiber response 0.277316632462835 0.555191246077507 0.773339553326725 0.545454545454545 23.2 23 2 abnormal ureter development 0.277316632462835 0.555191246077507 0.773339553326725 0.545454545454545 23.2 23 2 abnormal pituitary gland development 0.277316632462835 0.555191246077507 0.773339553326725 0.545454545454545 23.2 23 2 increased motor neuron number 0.277316632462835 0.555191246077507 0.773339553326725 0.545454545454545 23.2 23 2 abnormal phrenic nerve innervation pattern to diaphragm 0.277316632462835 0.555191246077507 0.773339553326725 0.545454545454545 23.2 23 2 hunched posture 0.012851497560472 0.0605456442834738 0.771708035281731 0.544303797468354 23.2 23 2 impaired fertilization 0.0195989337361526 0.08590722056155 0.769656984025169 0.542857142857143 23.2 23 2 syndactyly 0.0310426599115453 0.116556402309387 0.76897040330793 0.542372881355932 23.2 23 2 hypopigmentation 0.143196106298795 0.371235345928352 0.767969139761956 0.541666666666667 23.2 23 2 impaired skeletal muscle contractility 0.0814026766574997 0.24062882731495 0.766372530323781 0.540540540540541 23.2 23 2 increased trabecular bone volume 0.0814026766574997 0.24062882731495 0.766372530323781 0.540540540540541 23.2 23 2 decreased respiratory quotient 0.0481645484649014 0.165026603727882 0.765606157793457 0.54 23.2 23 2 abnormal mast cell morphology 0.261059784264071 0.526458219178661 0.76342494366869 0.538461538461538 23.2 23 2 tight skin 0.261059784264071 0.526458219178661 0.76342494366869 0.538461538461538 23.2 23 2 excessive scratching 0.261059784264071 0.526458219178661 0.76342494366869 0.538461538461538 23.2 23 2 abnormal GABAergic neuron morphology 0.261059784264071 0.526458219178661 0.76342494366869 0.538461538461538 23.2 23 2 abnormal insulin secretion 0.261059784264071 0.526458219178661 0.76342494366869 0.538461538461538 23.2 23 2 abnormal vestibulocochlear ganglion morphology 0.261059784264071 0.526458219178661 0.76342494366869 0.538461538461538 23.2 23 2 increased circulating thyroid-stimulating hormone level 0.261059784264071 0.526458219178661 0.76342494366869 0.538461538461538 23.2 23 2 increased circulating ammonia level 0.261059784264071 0.526458219178661 0.76342494366869 0.538461538461538 23.2 23 2 small pituitary gland 0.261059784264071 0.526458219178661 0.76342494366869 0.538461538461538 23.2 23 2 small lens 0.078487878879935 0.232288636185411 0.76342494366869 0.538461538461538 23.2 23 2 polyphagia 0.0450236482245758 0.16102994242794 0.761405300960571 0.537037037037037 23.2 23 2 scaly skin 0.0756634328424635 0.224062844280509 0.760764926443363 0.536585365853659 23.2 23 2 short humerus 0.0756634328424635 0.224062844280509 0.760764926443363 0.536585365853659 23.2 23 2 decreased anxiety-related response 0.00388353776655523 0.0244255377858562 0.760764926443363 0.536585365853659 23.2 23 2 arrest of spermatogenesis 0.0158071594893267 0.0713738957272022 0.75952991844589 0.535714285714286 23.2 23 2 decreased inflammatory response 0.0158071594893267 0.0713738957272022 0.75952991844589 0.535714285714286 23.2 23 2 abnormal ovulation 0.131607738313738 0.342262675436931 0.75952991844589 0.535714285714286 23.2 23 2 abnormal respiration 0.131607738313738 0.342262675436931 0.75952991844589 0.535714285714286 23.2 23 2 abnormal retinal inner nuclear layer morphology 0.131607738313738 0.342262675436931 0.75952991844589 0.535714285714286 23.2 23 2 abnormal hormone level 0.131607738313738 0.342262675436931 0.75952991844589 0.535714285714286 23.2 23 2 altered response to myocardial infarction 0.0702893641978161 0.214474052651097 0.756154229919464 0.533333333333333 23.2 23 2 lethality at weaning, complete penetrance 0.0702893641978161 0.214474052651097 0.756154229919464 0.533333333333333 23.2 23 2 enhanced paired-pulse facilitation 0.126195000313272 0.328873822188856 0.756154229919464 0.533333333333333 23.2 23 2 interdigital webbing 0.246413906153238 0.499555494340814 0.756154229919464 0.533333333333333 23.2 23 2 decreased salivation 0.246413906153238 0.499555494340814 0.756154229919464 0.533333333333333 23.2 23 2 hyperpigmentation 0.246413906153238 0.499555494340814 0.756154229919464 0.533333333333333 23.2 23 2 audiogenic seizures 0.246413906153238 0.499555494340814 0.756154229919464 0.533333333333333 23.2 23 2 abnormal cricoid cartilage morphology 0.246413906153238 0.499555494340814 0.756154229919464 0.533333333333333 23.2 23 2 arthritis 0.246413906153238 0.499555494340814 0.756154229919464 0.533333333333333 23.2 23 2 abnormal zygomatic bone morphology 0.246413906153238 0.499555494340814 0.756154229919464 0.533333333333333 23.2 23 2 abnormal Muller cell morphology 0.246413906153238 0.499555494340814 0.756154229919464 0.533333333333333 23.2 23 2 herniated liver 0.246413906153238 0.499555494340814 0.756154229919464 0.533333333333333 23.2 23 2 abnormal diaphragm morphology 0.121026062831497 0.315568481439569 0.753200502458841 0.53125 23.2 23 2 abnormal lumbar vertebrae morphology 0.121026062831497 0.315568481439569 0.753200502458841 0.53125 23.2 23 2 decreased osteoblast cell number 0.116091169328101 0.305736737517484 0.750594272346527 0.529411764705882 23.2 23 2 abnormal duodenum morphology 0.233092536964342 0.474288495459142 0.750594272346527 0.529411764705882 23.2 23 2 abnormal survival 0.233092536964342 0.474288495459142 0.750594272346527 0.529411764705882 23.2 23 2 abnormal reproductive system physiology 0.106882062054265 0.301465094728002 0.746204832157366 0.526315789473684 23.2 23 2 thin dermal layer 0.220886185307728 0.450372447502437 0.746204832157366 0.526315789473684 23.2 23 2 decreased germ cell number 0.220886185307728 0.450372447502437 0.746204832157366 0.526315789473684 23.2 23 2 maternal imprinting 0.220886185307728 0.450372447502437 0.746204832157366 0.526315789473684 23.2 23 2 abnormal photoreceptor inner segment morphology 0.220886185307728 0.450372447502437 0.746204832157366 0.526315789473684 23.2 23 2 decreased liver glycogen level 0.220886185307728 0.450372447502437 0.746204832157366 0.526315789473684 23.2 23 2 abnormal CNS synaptic transmission 0.0160799116799431 0.0723305249617693 0.744697347647957 0.525252525252525 23.2 23 2 increased susceptibility to weight loss 0.102587045748937 0.290148125412711 0.744339320076972 0.525 23.2 23 2 abnormal male meiosis 0.0522774925620142 0.17887243844293 0.743758258937178 0.524590163934426 23.2 23 2 abnormal excitatory postsynaptic potential 0.0277186216261593 0.113004200373903 0.743474814478741 0.524390243902439 23.2 23 2 abnormal nervous system electrophysiology 0.0267661588176659 0.110888577749244 0.742651475813759 0.523809523809524 23.2 23 2 skin lesions 0.0503818434347936 0.172504935366895 0.742651475813759 0.523809523809524 23.2 23 2 abnormal optic nerve morphology 0.098484895655094 0.278863036928909 0.742651475813759 0.523809523809524 23.2 23 2 abnormal vibrissa morphology 0.098484895655094 0.278863036928909 0.742651475813759 0.523809523809524 23.2 23 2 small ears 0.209635771330616 0.428311278180622 0.742651475813759 0.523809523809524 23.2 23 2 abnormal bile salt homeostasis 0.209635771330616 0.428311278180622 0.742651475813759 0.523809523809524 23.2 23 2 decreased vocalization 0.209635771330616 0.428311278180622 0.742651475813759 0.523809523809524 23.2 23 2 decreased sensitivity to induced morbidity/mortality 0.0945659481647607 0.27748705936172 0.741117071938111 0.522727272727273 23.2 23 2 abnormal sacral vertebrae morphology 0.199216854742021 0.407693892365921 0.739716094486432 0.521739130434783 23.2 23 2 abnormal regulatory T cell physiology 0.199216854742021 0.407693892365921 0.739716094486432 0.521739130434783 23.2 23 2 abnormal ulna morphology 0.199216854742021 0.407693892365921 0.739716094486432 0.521739130434783 23.2 23 2 abnormal corneal stroma morphology 0.199216854742021 0.407693892365921 0.739716094486432 0.521739130434783 23.2 23 2 abnormal lens development 0.199216854742021 0.407693892365921 0.739716094486432 0.521739130434783 23.2 23 2 abnormal hair shaft morphology 0.0872411895278444 0.25758155365046 0.738431865155727 0.520833333333333 23.2 23 2 abnormal phalanx morphology 0.0872411895278444 0.25758155365046 0.738431865155727 0.520833333333333 23.2 23 2 decreased placenta weight 0.189529727090865 0.4070853915146 0.737250374171478 0.52 23.2 23 2 cryptorchism 0.180492899984043 0.4070853915146 0.735149945755034 0.518518518518518 23.2 23 2 seizures 0.0158528954328761 0.0713738957272022 0.733768084954743 0.517543859649123 23.2 23 2 abnormal enzyme/coenzyme level 0.0715443954791281 0.216197682213417 0.733339231602928 0.517241379310345 23.2 23 2 abnormal middle ear morphology 0.172038662973443 0.393152204084923 0.733339231602928 0.517241379310345 23.2 23 2 absent long term depression 0.172038662973443 0.393152204084923 0.733339231602928 0.517241379310345 23.2 23 2 abnormal eye physiology 0.0687962198540695 0.214474052651097 0.732524410234481 0.516666666666667 23.2 23 2 abnormal nose morphology 0.164109957287659 0.391272038095932 0.731762157986578 0.516129032258065 23.2 23 2 belly spot 0.156658116460856 0.391272038095932 0.730376244808573 0.515151515151515 23.2 23 2 absent vibrissae 0.156658116460856 0.391272038095932 0.730376244808573 0.515151515151515 23.2 23 2 head tossing 0.156658116460856 0.391272038095932 0.730376244808573 0.515151515151515 23.2 23 2 cardiovascular system phenotype 0.156658116460856 0.391272038095932 0.730376244808573 0.515151515151515 23.2 23 2 decreased sensitivity to xenobiotic induced morbidity/mortality 0.156658116460856 0.391272038095932 0.730376244808573 0.515151515151515 23.2 23 2 abnormal pancreatic beta cell physiology 0.14302271183736 0.370979140454048 0.728053903807592 0.513513513513513 23.2 23 2 abnormal iris morphology 0.136770675921981 0.355132626676335 0.727071374922562 0.512820512820513 23.2 23 2 abnormal lens fiber morphology 0.136770675921981 0.355132626676335 0.727071374922562 0.512820512820513 23.2 23 2 increased circulating corticosterone level 0.119946013221113 0.313080490962768 0.72464780367282 0.511111111111111 23.2 23 2 decreased osteoclast cell number 0.119946013221113 0.313080490962768 0.72464780367282 0.511111111111111 23.2 23 2 increased anxiety-related response 0.0128415120102489 0.0605456442834738 0.724194473798767 0.510791366906475 23.2 23 2 increased circulating glucose level 0.0123985888674323 0.0593550206140278 0.72397745417821 0.51063829787234 23.2 23 2 abnormal epidermis stratum corneum morphology 0.110119157813054 0.301675556233449 0.723361827091324 0.510204081632653 23.2 23 2 decreased urine osmolality 0.110119157813054 0.301675556233449 0.723361827091324 0.510204081632653 23.2 23 2 increased fluid intake 0.110119157813054 0.301675556233449 0.723361827091324 0.510204081632653 23.2 23 2 abnormal cardiovascular system morphology 0.142571670974961 0.370002119509875 0.708894590549498 0.5 23.2 23 2 increased stereotypic behavior 0.255237603185246 0.516601739563304 0.708894590549498 0.5 23.2 23 2 prolonged QT interval 0.255237603185246 0.516601739563304 0.708894590549498 0.5 23.2 23 2 abnormal osteoblast morphology 0.255237603185246 0.516601739563304 0.708894590549498 0.5 23.2 23 2 abnormal retinal ganglion layer morphology 0.255237603185246 0.516601739563304 0.708894590549498 0.5 23.2 23 2 abnormal enteric nervous system morphology 0.371363414468377 0.596597543486509 0.708894590549498 0.5 23.2 23 2 abnormal glossopharyngeal nerve morphology 0.371363414468377 0.596597543486509 0.708894590549498 0.5 23.2 23 2 abnormal corticospinal tract morphology 0.371363414468377 0.596597543486509 0.708894590549498 0.5 23.2 23 2 decreased synaptic depression 0.371363414468377 0.596597543486509 0.708894590549498 0.5 23.2 23 2 absent tail 0.371363414468377 0.596597543486509 0.708894590549498 0.5 23.2 23 2 abnormal somatic nervous system physiology 0.371363414468377 0.596597543486509 0.708894590549498 0.5 23.2 23 2 impaired behavioral response to cocaine 0.371363414468377 0.596597543486509 0.708894590549498 0.5 23.2 23 2 decreased oligodendrocyte number 0.371363414468377 0.596597543486509 0.708894590549498 0.5 23.2 23 2 abnormal aorta elastic tissue morphology 0.371363414468377 0.596597543486509 0.708894590549498 0.5 23.2 23 2 increased type II pneumocyte number 0.371363414468377 0.596597543486509 0.708894590549498 0.5 23.2 23 2 decreased compensatory feeding amount 0.371363414468377 0.596597543486509 0.708894590549498 0.5 23.2 23 2 abnormal social investigation 0.0732657381481607 0.217221124724135 0.708894590549498 0.5 23.2 23 2 abnormal action potential 0.0895378182113391 0.264205602373317 0.708894590549498 0.5 23.2 23 2 abnormal eye development 0.119812955279559 0.313061687245696 0.708894590549498 0.5 23.2 23 2 abnormal circadian rhythm 0.1559462468377 0.391272038095932 0.708894590549498 0.5 23.2 23 2 short radius 0.187902400359783 0.4070853915146 0.708894590549498 0.5 23.2 23 2 increased susceptibility to weight gain 0.197225063593611 0.4070853915146 0.708894590549498 0.5 23.2 23 2 abnormal auditory brainstem response waveform shape 0.207193851743823 0.423844330767071 0.708894590549498 0.5 23.2 23 2 abnormal stria vascularis morphology 0.229378061654348 0.467112507871627 0.708894590549498 0.5 23.2 23 2 decreased circulating progesterone level 0.229378061654348 0.467112507871627 0.708894590549498 0.5 23.2 23 2 aphakia 0.269892016671207 0.543608414145448 0.708894590549498 0.5 23.2 23 2 abnormal temporal bone morphology 0.269892016671207 0.543608414145448 0.708894590549498 0.5 23.2 23 2 abnormal basioccipital bone morphology 0.285955109818132 0.570191050639362 0.708894590549498 0.5 23.2 23 2 brain inflammation 0.285955109818132 0.570191050639362 0.708894590549498 0.5 23.2 23 2 abnormal dopamine level 0.285955109818132 0.570191050639362 0.708894590549498 0.5 23.2 23 2 abnormal postnatal subventricular zone morphology 0.285955109818132 0.570191050639362 0.708894590549498 0.5 23.2 23 2 decreased muscle cell glucose uptake 0.285955109818132 0.570191050639362 0.708894590549498 0.5 23.2 23 2 abnormal bone marrow cell number 0.323469686852155 0.596597543486509 0.708894590549498 0.5 23.2 23 2 abnormal heart shape 0.303694474744826 0.596597543486509 0.708894590549498 0.5 23.2 23 2 absent atrioventricular cushions 0.345782016733941 0.596597543486509 0.708894590549498 0.5 23.2 23 2 absent maxillary shelf 0.401348956257112 0.596597543486509 0.708894590549498 0.5 23.2 23 2 increased cranium width 0.401348956257112 0.596597543486509 0.708894590549498 0.5 23.2 23 2 small petrosal ganglion 0.401348956257112 0.596597543486509 0.708894590549498 0.5 23.2 23 2 increased aggression towards males 0.345782016733941 0.596597543486509 0.708894590549498 0.5 23.2 23 2 abnormal placing response 0.345782016733941 0.596597543486509 0.708894590549498 0.5 23.2 23 2 absent trophoblast giant cells 0.401348956257112 0.596597543486509 0.708894590549498 0.5 23.2 23 2 abnormal extraembryonic endoderm formation 0.323469686852155 0.596597543486509 0.708894590549498 0.5 23.2 23 2 decreased incidence of induced tumors 0.401348956257112 0.596597543486509 0.708894590549498 0.5 23.2 23 2 decreased circulating parathyroid hormone level 0.401348956257112 0.596597543486509 0.708894590549498 0.5 23.2 23 2 abnormal endplate potential 0.345782016733941 0.596597543486509 0.708894590549498 0.5 23.2 23 2 white spotting 0.323469686852155 0.596597543486509 0.708894590549498 0.5 23.2 23 2 abnormal primordial germ cell migration 0.401348956257112 0.596597543486509 0.708894590549498 0.5 23.2 23 2 abnormal bone healing 0.401348956257112 0.596597543486509 0.708894590549498 0.5 23.2 23 2 delayed dark adaptation 0.401348956257112 0.596597543486509 0.708894590549498 0.5 23.2 23 2 abnormal kidney medulla morphology 0.345782016733941 0.596597543486509 0.708894590549498 0.5 23.2 23 2 abnormal epicardium morphology 0.323469686852155 0.596597543486509 0.708894590549498 0.5 23.2 23 2 intestinal obstruction 0.345782016733941 0.596597543486509 0.708894590549498 0.5 23.2 23 2 lymphedema 0.401348956257112 0.596597543486509 0.708894590549498 0.5 23.2 23 2 abnormal imprinting 0.345782016733941 0.596597543486509 0.708894590549498 0.5 23.2 23 2 abnormal hair cuticle 0.345782016733941 0.596597543486509 0.708894590549498 0.5 23.2 23 2 abnormal decidualization 0.345782016733941 0.596597543486509 0.708894590549498 0.5 23.2 23 2 abnormal hindlimb zeugopod morphology 0.401348956257112 0.596597543486509 0.708894590549498 0.5 23.2 23 2 increased defecation amount 0.401348956257112 0.596597543486509 0.708894590549498 0.5 23.2 23 2 abnormal ear physiology 0.401348956257112 0.596597543486509 0.708894590549498 0.5 23.2 23 2 abnormal reproductive system development 0.401348956257112 0.596597543486509 0.708894590549498 0.5 23.2 23 2 abnormal placental transport 0.401348956257112 0.596597543486509 0.708894590549498 0.5 23.2 23 2 bowed radius 0.323469686852155 0.596597543486509 0.708894590549498 0.5 23.2 23 2 decreased cochlear inner hair cell number 0.401348956257112 0.596597543486509 0.708894590549498 0.5 23.2 23 2 abnormal cochlear inner hair cell physiology 0.401348956257112 0.596597543486509 0.708894590549498 0.5 23.2 23 2 abnormal iris pigmentation 0.345782016733941 0.596597543486509 0.708894590549498 0.5 23.2 23 2 decreased circulating prolactin level 0.323469686852155 0.596597543486509 0.708894590549498 0.5 23.2 23 2 abnormal Langerhans cell physiology 0.323469686852155 0.596597543486509 0.708894590549498 0.5 23.2 23 2 decreased creatinine clearance 0.323469686852155 0.596597543486509 0.708894590549498 0.5 23.2 23 2 abnormal developmental vascular remodeling 0.401348956257112 0.596597543486509 0.708894590549498 0.5 23.2 23 2 impaired behavioral response to addictive substance 0.323469686852155 0.596597543486509 0.708894590549498 0.5 23.2 23 2 abnormal sperm principal piece morphology 0.401348956257112 0.596597543486509 0.708894590549498 0.5 23.2 23 2 abnormal hippocampus neuron morphology 0.401348956257112 0.596597543486509 0.708894590549498 0.5 23.2 23 2 increased lung compliance 0.345782016733941 0.596597543486509 0.708894590549498 0.5 23.2 23 2 abnormal pulmonary interalveolar septum morphology 0.401348956257112 0.596597543486509 0.708894590549498 0.5 23.2 23 2 decreased fluid intake 0.303694474744826 0.596597543486509 0.708894590549498 0.5 23.2 23 2 decreased midbrain size 0.323469686852155 0.596597543486509 0.708894590549498 0.5 23.2 23 2 decreased adipocyte glucose uptake 0.323469686852155 0.596597543486509 0.708894590549498 0.5 23.2 23 2 hyperkeratosis 0.112842169992234 0.305736737517484 0.698620755903853 0.492753623188406 23.2 23 2 abnormal cued conditioning behavior 0.166085731764617 0.391272038095932 0.694994696617155 0.490196078431373 23.2 23 2 abnormal excitatory postsynaptic currents 0.114368600881128 0.305736737517484 0.690717806176434 0.487179487179487 23.2 23 2 focal hair loss 0.282894833756528 0.565448693426567 0.684449949496067 0.482758620689655 23.2 23 2 decreased retinal photoreceptor cell number 0.282894833756528 0.565448693426567 0.684449949496067 0.482758620689655 23.2 23 2 enlarged epididymis 0.282894833756528 0.565448693426567 0.684449949496067 0.482758620689655 23.2 23 2 decreased susceptibility to pharmacologically induced seizures 0.298702368177675 0.588765563266218 0.682639235343961 0.481481481481481 23.2 23 2 decreased food intake 0.135100887521731 0.35116348768057 0.681974542807111 0.481012658227848 23.2 23 2 decreased acute inflammation 0.315891027272368 0.596597543486509 0.680538806927518 0.48 23.2 23 2 abnormal vertebrae development 0.315891027272368 0.596597543486509 0.680538806927518 0.48 23.2 23 2 abnormal inner ear morphology 0.228248934797839 0.465193957648197 0.678073086612563 0.478260869565217 23.2 23 2 bidirectional circling 0.334677581772962 0.596597543486509 0.678073086612563 0.478260869565217 23.2 23 2 abnormal nasal cavity morphology 0.334677581772962 0.596597543486509 0.678073086612563 0.478260869565217 23.2 23 2 dry skin 0.355336326624965 0.596597543486509 0.675137705285236 0.476190476190476 23.2 23 2 increased bone ossification 0.355336326624965 0.596597543486509 0.675137705285236 0.476190476190476 23.2 23 2 impaired ovarian folliculogenesis 0.26330117645498 0.53076310893984 0.673449861022023 0.475 23.2 23 2 irregular coat pigmentation 0.378221935238213 0.596597543486509 0.671584348941629 0.473684210526316 23.2 23 2 abnormal nail morphology 0.378221935238213 0.596597543486509 0.671584348941629 0.473684210526316 23.2 23 2 abnormal optic vesicle formation 0.378221935238213 0.596597543486509 0.671584348941629 0.473684210526316 23.2 23 2 right-sided stomach 0.378221935238213 0.596597543486509 0.671584348941629 0.473684210526316 23.2 23 2 abnormal reflex 0.290716473217984 0.579452906353954 0.669511557741192 0.472222222222222 23.2 23 2 distended urinary bladder 0.403804931196877 0.596597543486509 0.667194908752468 0.470588235294118 23.2 23 2 decreased pancreatic beta cell number 0.305896303935951 0.596597543486509 0.667194908752468 0.470588235294118 23.2 23 2 abnormal testis development 0.403804931196877 0.596597543486509 0.667194908752468 0.470588235294118 23.2 23 2 decreased growth hormone level 0.403804931196877 0.596597543486509 0.667194908752468 0.470588235294118 23.2 23 2 common atrium 0.403804931196877 0.596597543486509 0.667194908752468 0.470588235294118 23.2 23 2 decreased susceptibility to parasitic infection 0.322205746735113 0.596597543486509 0.664588678640154 0.46875 23.2 23 2 abnormal serotonin level 0.322205746735113 0.596597543486509 0.664588678640154 0.46875 23.2 23 2 abnormal cartilage development 0.281952929909481 0.564246108728748 0.661634951179531 0.466666666666667 23.2 23 2 abnormal enteric neuron morphology 0.432729113492056 0.622263046006746 0.661634951179531 0.466666666666667 23.2 23 2 abnormal seizure response to electrical stimulation 0.432729113492056 0.622263046006746 0.661634951179531 0.466666666666667 23.2 23 2 abnormal respiratory system morphology 0.432729113492056 0.622263046006746 0.661634951179531 0.466666666666667 23.2 23 2 lactation failure 0.432729113492056 0.622263046006746 0.661634951179531 0.466666666666667 23.2 23 2 abnormal jaw morphology 0.358783433831225 0.596597543486509 0.658259262653105 0.464285714285714 23.2 23 2 enhanced coordination 0.358783433831225 0.596597543486509 0.658259262653105 0.464285714285714 23.2 23 2 abnormal brain wave pattern 0.285517753167061 0.570191050639362 0.654364237430305 0.461538461538462 23.2 23 2 small seminal vesicle 0.379409023528683 0.596597543486509 0.654364237430305 0.461538461538462 23.2 23 2 abnormal ocular fundus morphology 0.379409023528683 0.596597543486509 0.654364237430305 0.461538461538462 23.2 23 2 absent trabeculae carneae 0.465909383214926 0.660182051123399 0.654364237430305 0.461538461538462 23.2 23 2 dystrophic cardiac calcinosis 0.465909383214926 0.660182051123399 0.654364237430305 0.461538461538462 23.2 23 2 increased synaptic depression 0.465909383214926 0.660182051123399 0.654364237430305 0.461538461538462 23.2 23 2 anal atresia 0.465909383214926 0.660182051123399 0.654364237430305 0.461538461538462 23.2 23 2 muscle fatigue 0.465909383214926 0.660182051123399 0.654364237430305 0.461538461538462 23.2 23 2 vestibular hair cell degeneration 0.465909383214926 0.660182051123399 0.654364237430305 0.461538461538462 23.2 23 2 hyperalgesia 0.465909383214926 0.660182051123399 0.654364237430305 0.461538461538462 23.2 23 2 increased renin activity 0.465909383214926 0.660182051123399 0.654364237430305 0.461538461538462 23.2 23 2 abnormal gut flora balance 0.465909383214926 0.660182051123399 0.654364237430305 0.461538461538462 23.2 23 2 abnormal digestive system morphology 0.401896025193336 0.596597543486509 0.64982004133704 0.458333333333333 23.2 23 2 abnormal vasodilation 0.401896025193336 0.596597543486509 0.64982004133704 0.458333333333333 23.2 23 2 decreased ovulation rate 0.401896025193336 0.596597543486509 0.64982004133704 0.458333333333333 23.2 23 2 increased coping response 0.426539918253097 0.614370611843995 0.644449627772271 0.454545454545455 23.2 23 2 abnormal cochlear sensory epithelium morphology 0.426539918253097 0.614370611843995 0.644449627772271 0.454545454545455 23.2 23 2 abnormal female reproductive system physiology 0.426539918253097 0.614370611843995 0.644449627772271 0.454545454545455 23.2 23 2 abnormal enteric ganglia morphology 0.504709226085675 0.69922818150271 0.644449627772271 0.454545454545455 23.2 23 2 secondary sex reversal 0.504709226085675 0.69922818150271 0.644449627772271 0.454545454545455 23.2 23 2 abnormal primary sex determination 0.504709226085675 0.69922818150271 0.644449627772271 0.454545454545455 23.2 23 2 abnormal frequency of paradoxical sleep 0.504709226085675 0.69922818150271 0.644449627772271 0.454545454545455 23.2 23 2 dilated renal glomerular capsule 0.504709226085675 0.69922818150271 0.644449627772271 0.454545454545455 23.2 23 2 enlarged placenta 0.504709226085675 0.69922818150271 0.644449627772271 0.454545454545455 23.2 23 2 increased circulating triiodothyronine level 0.504709226085675 0.69922818150271 0.644449627772271 0.454545454545455 23.2 23 2 abnormal platelet aggregation 0.504709226085675 0.69922818150271 0.644449627772271 0.454545454545455 23.2 23 2 abnormal superovulation 0.504709226085675 0.69922818150271 0.644449627772271 0.454545454545455 23.2 23 2 enhanced behavioral response to addictive substance 0.504709226085675 0.69922818150271 0.644449627772271 0.454545454545455 23.2 23 2 palatal shelf hypoplasia 0.504709226085675 0.69922818150271 0.644449627772271 0.454545454545455 23.2 23 2 abnormal palatal shelf elevation 0.504709226085675 0.69922818150271 0.644449627772271 0.454545454545455 23.2 23 2 abnormal dendritic cell chemotaxis 0.504709226085675 0.69922818150271 0.644449627772271 0.454545454545455 23.2 23 2 increased subcutaneous adipose tissue amount 0.504709226085675 0.69922818150271 0.644449627772271 0.454545454545455 23.2 23 2 abnormal body temperature homeostasis 0.398652307992656 0.596597543486509 0.640291888238256 0.451612903225806 23.2 23 2 decreased susceptibility to bacterial infection induced morbidity/mortality 0.398652307992656 0.596597543486509 0.640291888238256 0.451612903225806 23.2 23 2 abnormal male reproductive system physiology 0.453712974218279 0.644736374389015 0.638005131494548 0.45 23.2 23 2 stomach inflammation 0.420442921391917 0.606115193835059 0.635560667389205 0.448275862068966 23.2 23 2 abnormal systemic arterial blood pressure 0.414642827223428 0.597926975488857 0.630128524932887 0.444444444444444 23.2 23 2 lowered ear position 0.483893296358518 0.673766904389484 0.630128524932887 0.444444444444444 23.2 23 2 abnormal stomach glandular epithelium morphology 0.483893296358518 0.673766904389484 0.630128524932887 0.444444444444444 23.2 23 2 abnormal anterior eye segment morphology 0.483893296358518 0.673766904389484 0.630128524932887 0.444444444444444 23.2 23 2 abnormal cochlea morphology 0.371064998268306 0.596597543486509 0.630128524932887 0.444444444444444 23.2 23 2 abnormal palate morphology 0.443974347809488 0.631077822957772 0.630128524932887 0.444444444444444 23.2 23 2 abnormal inhibitory postsynaptic currents 0.36509509611414 0.596597543486509 0.625495226955439 0.441176470588235 23.2 23 2 abnormal bone remodeling 0.435663241078704 0.622263046006746 0.625495226955439 0.441176470588235 23.2 23 2 abnormal digestive system physiology 0.403960783874952 0.596597543486509 0.623827239683558 0.44 23.2 23 2 abnormal energy expenditure 0.469471380702668 0.665039897208364 0.623827239683558 0.44 23.2 23 2 short ulna 0.428309303058265 0.616740602811829 0.622444030726388 0.439024390243902 23.2 23 2 abnormal long term potentiation 0.458110744526301 0.650799815539219 0.62028276673081 0.4375 23.2 23 2 abnormal tympanic ring morphology 0.517708667545312 0.716041318053357 0.62028276673081 0.4375 23.2 23 2 abnormal epididymis epithelium morphology 0.517708667545312 0.716041318053357 0.62028276673081 0.4375 23.2 23 2 abnormal pancreatic alpha cell morphology 0.517708667545312 0.716041318053357 0.62028276673081 0.4375 23.2 23 2 abnormal fertilization 0.517708667545312 0.716041318053357 0.62028276673081 0.4375 23.2 23 2 decreased skeletal muscle weight 0.517708667545312 0.716041318053357 0.62028276673081 0.4375 23.2 23 2 decreased epididymis weight 0.497203254007047 0.692105816643833 0.616430078738694 0.434782608695652 23.2 23 2 abnormal associative learning 0.527495459913265 0.728969420296804 0.607623934756712 0.428571428571429 23.2 23 2 increased vasoconstriction 0.527495459913265 0.728969420296804 0.607623934756712 0.428571428571429 23.2 23 2 hypoalgesia 0.527495459913265 0.728969420296804 0.607623934756712 0.428571428571429 23.2 23 2 abnormal vasoconstriction 0.556004908075665 0.740001181828901 0.607623934756712 0.428571428571429 23.2 23 2 abnormal zigzag hair morphology 0.556004908075665 0.740001181828901 0.607623934756712 0.428571428571429 23.2 23 2 abnormal pinna reflex 0.556004908075665 0.740001181828901 0.607623934756712 0.428571428571429 23.2 23 2 abnormal prepulse inhibition 0.556004908075665 0.740001181828901 0.607623934756712 0.428571428571429 23.2 23 2 abnormal uterus development 0.556004908075665 0.740001181828901 0.607623934756712 0.428571428571429 23.2 23 2 skeletal muscle necrosis 0.556004908075665 0.740001181828901 0.607623934756712 0.428571428571429 23.2 23 2 enlarged stomach 0.556004908075665 0.740001181828901 0.607623934756712 0.428571428571429 23.2 23 2 abnormal respiratory motile cilium physiology 0.556004908075665 0.740001181828901 0.607623934756712 0.428571428571429 23.2 23 2 head bobbing 0.501907814678373 0.698068598832794 0.602560401967073 0.425 23.2 23 2 abnormal skin pigmentation 0.501907814678373 0.698068598832794 0.602560401967073 0.425 23.2 23 2 decreased systemic arterial blood pressure 0.516835308676509 0.715828413325621 0.601486319254119 0.424242424242424 23.2 23 2 increased percent body fat/body weight 0.497557564230834 0.69240528169186 0.599833884311113 0.423076923076923 23.2 23 2 abnormal stomach morphology 0.535517109296924 0.735299008210903 0.599833884311113 0.423076923076923 23.2 23 2 flaky skin 0.560745195355103 0.745512385593703 0.596963865725893 0.421052631578947 23.2 23 2 decreased grooming behavior 0.560745195355103 0.745512385593703 0.596963865725893 0.421052631578947 23.2 23 2 abnormal response to novelty 0.560745195355103 0.745512385593703 0.596963865725893 0.421052631578947 23.2 23 2 decreased eye pigmentation 0.560745195355103 0.745512385593703 0.596963865725893 0.421052631578947 23.2 23 2 apnea 0.565279846016841 0.751139752653254 0.590745492124581 0.416666666666667 23.2 23 2 abnormal primitive streak formation 0.565279846016841 0.751139752653254 0.590745492124581 0.416666666666667 23.2 23 2 abnormal esophagus morphology 0.599956234383745 0.793614003206363 0.590745492124581 0.416666666666667 23.2 23 2 abnormal pilomotor reflex 0.599956234383745 0.793614003206363 0.590745492124581 0.416666666666667 23.2 23 2 increased litter size 0.599956234383745 0.793614003206363 0.590745492124581 0.416666666666667 23.2 23 2 increased circulating parathyroid hormone level 0.599956234383745 0.793614003206363 0.590745492124581 0.416666666666667 23.2 23 2 absent ovary 0.599956234383745 0.793614003206363 0.590745492124581 0.416666666666667 23.2 23 2 increased placenta weight 0.599956234383745 0.793614003206363 0.590745492124581 0.416666666666667 23.2 23 2 abnormal amacrine cell morphology 0.599956234383745 0.793614003206363 0.590745492124581 0.416666666666667 23.2 23 2 abnormal patella morphology 0.599956234383745 0.793614003206363 0.590745492124581 0.416666666666667 23.2 23 2 decreased prostaglandin level 0.599956234383745 0.793614003206363 0.590745492124581 0.416666666666667 23.2 23 2 abnormal respiratory motile cilium morphology 0.599956234383745 0.793614003206363 0.590745492124581 0.416666666666667 23.2 23 2 increased aggression towards mice 0.597441282989216 0.792816853259896 0.58379554515841 0.411764705882353 23.2 23 2 abnormal heart rate 0.597441282989216 0.792816853259896 0.58379554515841 0.411764705882353 23.2 23 2 abnormal tendon morphology 0.597441282989216 0.792816853259896 0.58379554515841 0.411764705882353 23.2 23 2 abnormal electroretinogram waveform feature 0.597441282989216 0.792816853259896 0.58379554515841 0.411764705882353 23.2 23 2 abnormal brain commissure morphology 0.598452757819537 0.793614003206363 0.577617814521813 0.407407407407407 23.2 23 2 abnormal single cell response 0.598452757819537 0.793614003206363 0.577617814521813 0.407407407407407 23.2 23 2 increased susceptibility to pharmacologically induced seizures 0.596543434488627 0.792470917645105 0.575976854821467 0.40625 23.2 23 2 increased systemic arterial blood pressure 0.606403414835531 0.801378754626493 0.573148817891083 0.404255319148936 23.2 23 2 abnormal inner ear vestibule morphology 0.629152156226289 0.807598508686611 0.567115672439598 0.4 23.2 23 2 abnormal stomach mucosa morphology 0.629152156226289 0.807598508686611 0.567115672439598 0.4 23.2 23 2 abnormal hearing physiology 0.632100009446319 0.807598508686611 0.567115672439598 0.4 23.2 23 2 abnormal pain threshold 0.627881215646035 0.807598508686611 0.567115672439598 0.4 23.2 23 2 decreased aggression towards males 0.638188771131404 0.807598508686611 0.567115672439598 0.4 23.2 23 2 abnormal rostral migratory stream morphology 0.638188771131404 0.807598508686611 0.567115672439598 0.4 23.2 23 2 abnormal incus morphology 0.632100009446319 0.807598508686611 0.567115672439598 0.4 23.2 23 2 nuclear cataracts 0.632100009446319 0.807598508686611 0.567115672439598 0.4 23.2 23 2 abnormal axon guidance 0.651665913795284 0.807598508686611 0.560521304155417 0.395348837209302 23.2 23 2 abnormal middle ear ossicle morphology 0.654208812747704 0.807598508686611 0.558523010735968 0.393939393939394 23.2 23 2 increased circulating luteinizing hormone level 0.657066726630705 0.808534990103328 0.556988606860319 0.392857142857143 23.2 23 2 abnormal retinal cone cell morphology 0.66179208197196 0.814148270971934 0.554787070864824 0.391304347826087 23.2 23 2 decreased heart rate variability 0.669699092663297 0.823468360355883 0.551362459316276 0.388888888888889 23.2 23 2 abnormal sperm axoneme morphology 0.669699092663297 0.823468360355883 0.551362459316276 0.388888888888889 23.2 23 2 small trigeminal ganglion 0.683735516364257 0.831979602869419 0.545303531191921 0.384615384615385 23.2 23 2 abnormal otolith morphology 0.683735516364257 0.831979602869419 0.545303531191921 0.384615384615385 23.2 23 2 abnormal dopaminergic neuron morphology 0.683735516364257 0.831979602869419 0.545303531191921 0.384615384615385 23.2 23 2 abnormal afterhyperpolarization 0.683735516364257 0.831979602869419 0.545303531191921 0.384615384615385 23.2 23 2 decreased endocochlear potential 0.683735516364257 0.831979602869419 0.545303531191921 0.384615384615385 23.2 23 2 abnormal tectorial membrane morphology 0.687674060557142 0.833620480329381 0.545303531191921 0.384615384615385 23.2 23 2 decreased cochlear coiling 0.71047683328306 0.858577104461403 0.531670942912123 0.375 23.2 23 2 decreased circulating growth hormone level 0.71047683328306 0.858577104461403 0.531670942912123 0.375 23.2 23 2 abnormal intestinal lipid absorption 0.71047683328306 0.858577104461403 0.531670942912123 0.375 23.2 23 2 abnormal ear morphology 0.733255532759744 0.883279969849812 0.522343382510156 0.368421052631579 23.2 23 2 abnormal behavioral response to xenobiotic 0.733255532759744 0.883279969849812 0.522343382510156 0.368421052631579 23.2 23 2 abnormal estrous cycle 0.758381560044683 0.910680246493434 0.519856033069631 0.366666666666667 23.2 23 2 abnormal synaptic transmission 0.758381560044683 0.910680246493434 0.519856033069631 0.366666666666667 23.2 23 2 abnormal basisphenoid bone morphology 0.753091629609632 0.904983298866647 0.515559702217816 0.363636363636364 23.2 23 2 intestinal ulcer 0.753091629609632 0.904983298866647 0.515559702217816 0.363636363636364 23.2 23 2 abnormal channel response 0.753091629609632 0.904983298866647 0.515559702217816 0.363636363636364 23.2 23 2 decreased vascular permeability 0.754696965413475 0.90669340809757 0.506353278963927 0.357142857142857 23.2 23 2 enlarged sebaceous gland 0.772132587988792 0.924987576683603 0.500396181564351 0.352941176470588 23.2 23 2 abnormal touch/ nociception 0.772132587988792 0.924987576683603 0.500396181564351 0.352941176470588 23.2 23 2 nephrocalcinosis 0.772132587988792 0.924987576683603 0.500396181564351 0.352941176470588 23.2 23 2 increased urine calcium level 0.787723891466972 0.924987576683603 0.496226213384648 0.35 23.2 23 2 enhanced behavioral response to xenobiotic 0.787723891466972 0.924987576683603 0.496226213384648 0.35 23.2 23 2 abnormal carpal bone morphology 0.801784721683057 0.927614372218488 0.493144062990955 0.347826086956522 23.2 23 2 impaired behavioral response to xenobiotic 0.846734904674807 0.977606440185 0.48609914780537 0.342857142857143 23.2 23 2 altered righting response 0.81295106255451 0.938818833846028 0.472596393699665 0.333333333333333 23.2 23 2 increased alcohol consumption 0.81295106255451 0.938818833846028 0.472596393699665 0.333333333333333 23.2 23 2 greasy coat 0.81295106255451 0.938818833846028 0.472596393699665 0.333333333333333 23.2 23 2 abnormal olfactory nerve morphology 0.81295106255451 0.938818833846028 0.472596393699665 0.333333333333333 23.2 23 2 decreased airway responsiveness 0.870803638128831 0.996324752284388 0.451114739440589 0.318181818181818 23.2 23 2 increased circulating estradiol level 0.859530257677897 0.986655060440133 0.443059119093436 0.3125 23.2 23 2 abnormal urinary bladder physiology 0.859530257677897 0.986655060440133 0.443059119093436 0.3125 23.2 23 2 increased dopamine level 0.911992239112399 1 0.443059119093436 0.3125 23.2 23 2 hypotension 0.900999414073858 1 0.431501055117086 0.304347826086957 23.2 23 2 increased susceptibility to age related obesity 0.900999414073858 1 0.431501055117086 0.304347826086957 23.2 23 2 abnormal crista ampullaris morphology 0.900999414073858 1 0.431501055117086 0.304347826086957 23.2 23 2 abnormal malleus morphology 0.924952608382829 1 0.413521844487207 0.291666666666667 23.2 23 2 abnormal stapes morphology 0.923887919890012 1 0.405082623171141 0.285714285714286 23.2 23 2 abnormal feces composition 0.943678023922067 1 0.396980970707719 0.28 23.2 23 2 decreased chemically-elicited antinociception 0.944916528931526 1 0.373102416078683 0.263157894736842 23.2 23 2 impaired conditioned place preference behavior 0.97859383533424 1 0.340269403463759 0.24 23.2 23 2 decreased mortality induced by ionizing radiation 7.82715227765803e-05 0.00142637665133145 2.85938566552901 1 24.1 24 1 abnormal leukocyte tethering or rolling 0.000302232867661208 0.00439651613045178 2.85938566552901 1 24.1 24 1 additional anastomosis between intracranial vertebral arteries 0.000302232867661208 0.00439651613045178 2.85938566552901 1 24.1 24 1 gastric polyps 0.00116692505841782 0.0129010048125081 2.85938566552901 1 24.1 24 1 decreased leukotriene level 0.00116692505841782 0.0129010048125081 2.85938566552901 1 24.1 24 1 decreased DN3 thymocyte number 0.00116692505841782 0.0129010048125081 2.85938566552901 1 24.1 24 1 aorta hypoplasia 0.00116692505841782 0.0129010048125081 2.85938566552901 1 24.1 24 1 increased osteosarcoma incidence 3.21975636130709e-06 8.6119827405929e-05 2.62110352673493 0.916666666666667 24.1 24 1 abnormal inferior vena cava valve morphology 4.02533133628371e-05 0.000810770178057145 2.57344709897611 0.9 24.1 24 1 increased neuronal precursor cell number 0.00014043336192967 0.00236626590307996 2.5416761471369 0.888888888888889 24.1 24 1 decreased effector memory CD4-positive, alpha-beta T cell number 0.00014043336192967 0.00236626590307996 2.5416761471369 0.888888888888889 24.1 24 1 colon polyps 0.000484290191121834 0.00624436524482865 2.50196245733788 0.875 24.1 24 1 tau protein deposits 0.000484290191121834 0.00624436524482865 2.50196245733788 0.875 24.1 24 1 abnormal kidney epithelium morphology 0.000484290191121834 0.00624436524482865 2.50196245733788 0.875 24.1 24 1 accumulation of giant lysosomes in kidney/renal tubule cells 0.000484290191121834 0.00624436524482865 2.50196245733788 0.875 24.1 24 1 pleural effusion 0.000484290191121834 0.00624436524482865 2.50196245733788 0.875 24.1 24 1 abnormal umbilical vein topology 0.000484290191121834 0.00624436524482865 2.50196245733788 0.875 24.1 24 1 increased brain apoptosis 0.000484290191121834 0.00624436524482865 2.50196245733788 0.875 24.1 24 1 decreased response to antigen 4.80286444707357e-06 0.000123804407379228 2.45090199902487 0.857142857142857 24.1 24 1 heart hemorrhage 0.00164600093696897 0.0168842364153003 2.45090199902487 0.857142857142857 24.1 24 1 decreased DN2 thymocyte number 0.00164600093696897 0.0168842364153003 2.45090199902487 0.857142857142857 24.1 24 1 decreased brain cholesterol level 0.00164600093696897 0.0168842364153003 2.45090199902487 0.857142857142857 24.1 24 1 ductus venosus stenosis 0.00164600093696897 0.0168842364153003 2.45090199902487 0.857142857142857 24.1 24 1 increased skin tumor incidence 5.20556393831905e-08 2.12276070435551e-06 2.43047781569966 0.85 24.1 24 1 abnormal lymph node cortex morphology 0.00549038601220084 0.0434946981062089 2.38282138794084 0.833333333333333 24.1 24 1 decreased liver function 0.00549038601220084 0.0434946981062089 2.38282138794084 0.833333333333333 24.1 24 1 enlarged pancreas 0.00549038601220084 0.0434946981062089 2.38282138794084 0.833333333333333 24.1 24 1 abnormal cholesterol level 0.00549038601220084 0.0434946981062089 2.38282138794084 0.833333333333333 24.1 24 1 delayed chorioallantoic fusion 0.00549038601220084 0.0434946981062089 2.38282138794084 0.833333333333333 24.1 24 1 abnormal olfactory bulb layer morphology 0.00549038601220084 0.0434946981062089 2.38282138794084 0.833333333333333 24.1 24 1 myocardium hypoplasia 0.00549038601220084 0.0434946981062089 2.38282138794084 0.833333333333333 24.1 24 1 thin hypoglossal nerve 0.000169960983722265 0.00273642684148306 2.33949736270555 0.818181818181818 24.1 24 1 reduced sympathetic cervical ganglion size 0.000169960983722265 0.00273642684148306 2.33949736270555 0.818181818181818 24.1 24 1 absent ductus venosus valve 6.49665665571517e-07 2.03275892214987e-05 2.28750853242321 0.8 24.1 24 1 abnormal lymph node B cell domain morphology 1.82979959875394e-05 0.000402798805477915 2.28750853242321 0.8 24.1 24 1 abnormal immune cell physiology 0.000541153556197 0.00678145829239314 2.28750853242321 0.8 24.1 24 1 decreased transitional stage T2 B cell number 0.000541153556197 0.00678145829239314 2.28750853242321 0.8 24.1 24 1 acanthocytosis 0.000541153556197 0.00678145829239314 2.28750853242321 0.8 24.1 24 1 subcutaneous edema 8.41277164069535e-09 4.06345037985042e-07 2.24666016577279 0.785714285714286 24.1 24 1 decreased cellular sensitivity to ionizing radiation 0.00168778909329441 0.0171712694051936 2.22396662874479 0.777777777777778 24.1 24 1 decreased transitional stage T1 B cell number 0.00168778909329441 0.0171712694051936 2.22396662874479 0.777777777777778 24.1 24 1 decreased platelet dense granule number 0.00168778909329441 0.0171712694051936 2.22396662874479 0.777777777777778 24.1 24 1 abnormal leukocyte cell number 7.7521433550738e-08 2.98968319313893e-06 2.19952743502232 0.769230769230769 24.1 24 1 increased foot pad pigmentation 0.000174159790526558 0.00279498373506331 2.19952743502232 0.769230769230769 24.1 24 1 impaired hematopoiesis 6.15773843887058e-14 8.06177598246872e-12 2.18658903834571 0.764705882352941 24.1 24 1 decreased metastatic potential 6.84485566548737e-07 2.11510291526706e-05 2.14453924914676 0.75 24.1 24 1 decreased mast cell number 5.58042057043677e-05 0.00106370085585912 2.14453924914676 0.75 24.1 24 1 decreased liver cholesterol level 5.58042057043677e-05 0.00106370085585912 2.14453924914676 0.75 24.1 24 1 interstitial pneumonia 0.000522411321215304 0.00664704941955534 2.14453924914676 0.75 24.1 24 1 abnormal pulmonary valve cusp morphology 0.000522411321215304 0.00664704941955534 2.14453924914676 0.75 24.1 24 1 abnormal vitelline vein connection 0.000522411321215304 0.00664704941955534 2.14453924914676 0.75 24.1 24 1 increased sensitivity to skin irradiation 0.00513113317451039 0.0419858347749822 2.14453924914676 0.75 24.1 24 1 abnormal atrial thrombosis 0.00513113317451039 0.0419858347749822 2.14453924914676 0.75 24.1 24 1 abnormal NK cell morphology 0.00513113317451039 0.0419858347749822 2.14453924914676 0.75 24.1 24 1 abnormal choroid pigmentation 0.00513113317451039 0.0419858347749822 2.14453924914676 0.75 24.1 24 1 abnormal sphingomyelin level 0.00513113317451039 0.0419858347749822 2.14453924914676 0.75 24.1 24 1 abnormal cerebellum deep nucleus morphology 0.00513113317451039 0.0419858347749822 2.14453924914676 0.75 24.1 24 1 myocardial trabeculae hypoplasia 0.00513113317451039 0.0419858347749822 2.14453924914676 0.75 24.1 24 1 decreased vascular endothelial cell proliferation 0.00513113317451039 0.0419858347749822 2.14453924914676 0.75 24.1 24 1 abnormal lysosome morphology 1.01478678674457e-09 6.31070533006777e-08 2.14453924914676 0.75 24.1 24 1 delayed intramembranous bone ossification 0.000163166211648541 0.00267023652286675 2.09688282138794 0.733333333333333 24.1 24 1 immune system phenotype 0.000163166211648541 0.00267023652286675 2.09688282138794 0.733333333333333 24.1 24 1 embryonic lethality before implantation, incomplete penetrance 5.74429796899865e-06 0.00014506539287192 2.07955321129383 0.727272727272727 24.1 24 1 abnormal thrombopoiesis 0.00153100041612963 0.0159679812793394 2.07955321129383 0.727272727272727 24.1 24 1 impaired myelopoiesis 0.00153100041612963 0.0159679812793394 2.07955321129383 0.727272727272727 24.1 24 1 increased number of Howell-Jolly bodies 0.00153100041612963 0.0159679812793394 2.07955321129383 0.727272727272727 24.1 24 1 abnormal cell nucleus morphology 3.60928792459451e-11 2.99270123747628e-09 2.06849175804226 0.723404255319149 24.1 24 1 abnormal megakaryocyte differentiation 5.13644262474356e-05 0.000990925710407017 2.06511186954873 0.722222222222222 24.1 24 1 abnormal thymus cortex morphology 5.13644262474356e-05 0.000990925710407017 2.06511186954873 0.722222222222222 24.1 24 1 abnormal neutrophil morphology 5.13644262474356e-05 0.000990925710407017 2.06511186954873 0.722222222222222 24.1 24 1 abnormal hypoglossal nerve topology 5.13644262474356e-05 0.000990925710407017 2.06511186954873 0.722222222222222 24.1 24 1 abnormal embryonic hematopoiesis 6.89518374574354e-08 2.67996399492766e-06 2.05518344709898 0.71875 24.1 24 1 increased fibroblast apoptosis 6.89518374574354e-08 2.67996399492766e-06 2.05518344709898 0.71875 24.1 24 1 embryonic lethality between somite formation and embryo turning, complete penetrance 2.03425813776066e-15 3.26465620495461e-13 2.04241833252072 0.714285714285714 24.1 24 1 abnormal erythrocyte physiology 1.62742240363386e-05 0.000363068451034908 2.04241833252072 0.714285714285714 24.1 24 1 embryonic lethality at implantation, complete penetrance 1.62742240363386e-05 0.000363068451034908 2.04241833252072 0.714285714285714 24.1 24 1 increased hemangioma incidence 0.000467235466433436 0.00614946149604853 2.04241833252072 0.714285714285714 24.1 24 1 failure of zygotic cell division 0.000467235466433436 0.00614946149604853 2.04241833252072 0.714285714285714 24.1 24 1 lysosomal protein accumulation 0.000467235466433436 0.00614946149604853 2.04241833252072 0.714285714285714 24.1 24 1 testis degeneration 0.000467235466433436 0.00614946149604853 2.04241833252072 0.714285714285714 24.1 24 1 multiple persisting craniopharyngeal ducts 0.000467235466433436 0.00614946149604853 2.04241833252072 0.714285714285714 24.1 24 1 broad head 0.0151013487002806 0.101388947076782 2.04241833252072 0.714285714285714 24.1 24 1 polyphalangy 0.0151013487002806 0.101388947076782 2.04241833252072 0.714285714285714 24.1 24 1 skin photosensitivity 0.0151013487002806 0.101388947076782 2.04241833252072 0.714285714285714 24.1 24 1 abnormal circulating alanine transaminase level 0.0151013487002806 0.101388947076782 2.04241833252072 0.714285714285714 24.1 24 1 decreased activated T cell number 0.0151013487002806 0.101388947076782 2.04241833252072 0.714285714285714 24.1 24 1 abnormal tumor incidence 0.0151013487002806 0.101388947076782 2.04241833252072 0.714285714285714 24.1 24 1 abnormal hypersensitivity reaction 0.0151013487002806 0.101388947076782 2.04241833252072 0.714285714285714 24.1 24 1 abnormal gastrulation movements 0.0151013487002806 0.101388947076782 2.04241833252072 0.714285714285714 24.1 24 1 aorta coarctation 0.0151013487002806 0.101388947076782 2.04241833252072 0.714285714285714 24.1 24 1 abnormal body temperature 0.0151013487002806 0.101388947076782 2.04241833252072 0.714285714285714 24.1 24 1 absent popliteal lymph nodes 0.0151013487002806 0.101388947076782 2.04241833252072 0.714285714285714 24.1 24 1 increased tumor latency 0.0151013487002806 0.101388947076782 2.04241833252072 0.714285714285714 24.1 24 1 decreased DN4 thymocyte number 0.0151013487002806 0.101388947076782 2.04241833252072 0.714285714285714 24.1 24 1 arteritis 0.0151013487002806 0.101388947076782 2.04241833252072 0.714285714285714 24.1 24 1 embryonic lethality at implantation, incomplete penetrance 0.0151013487002806 0.101388947076782 2.04241833252072 0.714285714285714 24.1 24 1 increased B cell derived lymphoma incidence 8.35612686267086e-11 6.59868748282342e-09 2.00156996587031 0.7 24.1 24 1 enlarged testis 0.00436327201318836 0.0371210766044577 2.00156996587031 0.7 24.1 24 1 abnormal gas homeostasis 0.00436327201318836 0.0371210766044577 2.00156996587031 0.7 24.1 24 1 absent inguinal lymph nodes 0.00436327201318836 0.0371210766044577 2.00156996587031 0.7 24.1 24 1 abnormal hematopoietic stem cell physiology 1.43101736750252e-05 0.000326573917583717 1.98913785428105 0.695652173913043 24.1 24 1 abnormal mast cell morphology 0.00130597726526498 0.0141494643025608 1.97957469152008 0.692307692307692 24.1 24 1 absent hypoglossal nerve 0.00130597726526498 0.0141494643025608 1.97957469152008 0.692307692307692 24.1 24 1 abnormal embryonic erythropoiesis 1.4512270219065e-06 4.29753240118145e-05 1.97199011415794 0.689655172413793 24.1 24 1 decreased lymphocyte cell number 3.60402702651407e-24 1.49416953807563e-21 1.96582764505119 0.6875 24.1 24 1 abnormal erythropoiesis 6.14667284861511e-20 1.69887207899223e-17 1.96072159921989 0.685714285714286 24.1 24 1 embryonic lethality between implantation and somite formation, incomplete penetrance 0.000123897696570076 0.00213284097036722 1.95642177115143 0.684210526315789 24.1 24 1 abnormal lysosome physiology 3.88383513234956e-05 0.000788656317691391 1.94958113558796 0.681818181818182 24.1 24 1 abnormal mesenteric lymph node morphology 3.88383513234956e-05 0.000788656317691391 1.94958113558796 0.681818181818182 24.1 24 1 extramedullary hematopoiesis 1.43029508889602e-19 3.55785903362884e-17 1.94222422564235 0.679245283018868 24.1 24 1 increased B cell proliferation 1.84316804622403e-11 1.63745732677939e-09 1.93856655290102 0.677966101694915 24.1 24 1 inner cell mass degeneration 1.24563463437041e-06 3.71079778801963e-05 1.93700319277772 0.67741935483871 24.1 24 1 abnormal spleen red pulp morphology 3.99421342043093e-07 1.35178311337713e-05 1.93429030315198 0.676470588235294 24.1 24 1 abnormal placenta vasculature 4.58123662658751e-10 3.03888696230305e-08 1.92458650564453 0.673076923076923 24.1 24 1 decreased B cell proliferation 1.9389501760473e-14 2.67952142384314e-12 1.91832202877263 0.670886075949367 24.1 24 1 spleen hyperplasia 1.54447904073463e-13 1.92094580691369e-11 1.90625711035267 0.666666666666667 24.1 24 1 abnormal tumor morphology 3.25633205361154e-05 0.000677834810322903 1.90625711035267 0.666666666666667 24.1 24 1 abnormal hematopoietic system physiology 0.000103442821052803 0.00183795726692033 1.90625711035267 0.666666666666667 24.1 24 1 abnormal tumor vascularization 0.000103442821052803 0.00183795726692033 1.90625711035267 0.666666666666667 24.1 24 1 myocarditis 0.00354817860595828 0.0316347465316172 1.90625711035267 0.666666666666667 24.1 24 1 increased papilloma incidence 0.00354817860595828 0.0316347465316172 1.90625711035267 0.666666666666667 24.1 24 1 altered tumor susceptibility 0.00354817860595828 0.0316347465316172 1.90625711035267 0.666666666666667 24.1 24 1 loss of dopaminergic neurons 0.00354817860595828 0.0316347465316172 1.90625711035267 0.666666666666667 24.1 24 1 small intestinal inflammation 0.00354817860595828 0.0316347465316172 1.90625711035267 0.666666666666667 24.1 24 1 abnormal rostral-caudal body axis extension 0.00354817860595828 0.0316347465316172 1.90625711035267 0.666666666666667 24.1 24 1 abnormal thymus corticomedullary boundary morphology 0.00354817860595828 0.0316347465316172 1.90625711035267 0.666666666666667 24.1 24 1 decreased mammary gland epithelial cell proliferation 0.00354817860595828 0.0316347465316172 1.90625711035267 0.666666666666667 24.1 24 1 increased fibrosarcoma incidence 0.00354817860595828 0.0316347465316172 1.90625711035267 0.666666666666667 24.1 24 1 prenatal growth retardation 0.00354817860595828 0.0316347465316172 1.90625711035267 0.666666666666667 24.1 24 1 decreased brown adipose tissue amount 1.05261094817183e-06 3.2018026651775e-05 1.90625711035267 0.666666666666667 24.1 24 1 abnormal redox activity 0.000331532239366532 0.00464612081929155 1.90625711035267 0.666666666666667 24.1 24 1 decreased cellular sensitivity to gamma-irradiation 0.000331532239366532 0.00464612081929155 1.90625711035267 0.666666666666667 24.1 24 1 absent inner cell mass 0.000331532239366532 0.00464612081929155 1.90625711035267 0.666666666666667 24.1 24 1 increased effector memory CD8-positive, alpha-beta T cell number 0.000331532239366532 0.00464612081929155 1.90625711035267 0.666666666666667 24.1 24 1 abnormal dendritic cell morphology 0.00107537397600323 0.012131486463982 1.90625711035267 0.666666666666667 24.1 24 1 decreased thymocyte apoptosis 0.00107537397600323 0.012131486463982 1.90625711035267 0.666666666666667 24.1 24 1 heterochrony 0.00107537397600323 0.012131486463982 1.90625711035267 0.666666666666667 24.1 24 1 decreased level of surface class I molecules 0.0120178213369423 0.0849270754989888 1.90625711035267 0.666666666666667 24.1 24 1 abnormal thymus lobule morphology 0.0120178213369423 0.0849270754989888 1.90625711035267 0.666666666666667 24.1 24 1 abnormal thymus physiology 0.0120178213369423 0.0849270754989888 1.90625711035267 0.666666666666667 24.1 24 1 decreased susceptibility to atherosclerosis 0.0120178213369423 0.0849270754989888 1.90625711035267 0.666666666666667 24.1 24 1 abnormal leukopoiesis 0.0120178213369423 0.0849270754989888 1.90625711035267 0.666666666666667 24.1 24 1 absent cervical lymph nodes 0.0120178213369423 0.0849270754989888 1.90625711035267 0.666666666666667 24.1 24 1 abnormal telomere morphology 0.0120178213369423 0.0849270754989888 1.90625711035267 0.666666666666667 24.1 24 1 trigeminal neuroma 0.0120178213369423 0.0849270754989888 1.90625711035267 0.666666666666667 24.1 24 1 abnormal infrahyoid muscle connection 0.0120178213369423 0.0849270754989888 1.90625711035267 0.666666666666667 24.1 24 1 abnormal coronary sinus connection 0.0120178213369423 0.0849270754989888 1.90625711035267 0.666666666666667 24.1 24 1 increased cardiac muscle glycogen level 0.0120178213369423 0.0849270754989888 1.90625711035267 0.666666666666667 24.1 24 1 decreased platelet aggregation 3.90107609373814e-10 2.65861007758182e-08 1.90625711035267 0.666666666666667 24.1 24 1 increased brain weight 1.03209019412314e-05 0.00024132398587844 1.90625711035267 0.666666666666667 24.1 24 1 increased granulocyte number 4.00343510334857e-13 4.42601991981314e-11 1.89337699474218 0.662162162162162 24.1 24 1 abnormal cell differentiation 9.13131922095661e-08 3.44153887304993e-06 1.88301007242154 0.658536585365854 24.1 24 1 abnormal CD8-positive, alpha-beta T cell physiology 8.5526937021998e-06 0.00020755927399241 1.87339060845004 0.655172413793103 24.1 24 1 blood in lymph vessels 8.5526937021998e-06 0.00020755927399241 1.87339060845004 0.655172413793103 24.1 24 1 liver hypoplasia 2.5995016236802e-09 1.43707906182926e-07 1.86959831976897 0.653846153846154 24.1 24 1 pulmonary edema 2.68602096941231e-05 0.000578482871118018 1.86959831976897 0.653846153846154 24.1 24 1 increased thymocyte apoptosis 2.68602096941231e-05 0.000578482871118018 1.86959831976897 0.653846153846154 24.1 24 1 increased T cell derived lymphoma incidence 7.99034555223788e-09 3.89725187474347e-07 1.86735390401895 0.653061224489796 24.1 24 1 abnormal lymphocyte physiology 2.4595356959811e-08 1.06401652934835e-06 1.86481673838848 0.652173913043478 24.1 24 1 abnormal vertebral artery topology 8.48286844143777e-05 0.00152906777159974 1.86481673838848 0.652173913043478 24.1 24 1 decreased myocardial infarction size 0.000269808347408252 0.00394793096575311 1.85860068259386 0.65 24.1 24 1 abnormal cell morphology 2.42920056590163e-18 5.49330582516391e-16 1.85609244955392 0.649122807017544 24.1 24 1 abnormal apoptosis 2.15666878070745e-09 1.23326749241604e-07 1.85330552395399 0.648148148148148 24.1 24 1 abnormal embryonic-extraembryonic boundary morphology 0.000866145658363131 0.0101389991773096 1.85019072475407 0.647058823529412 24.1 24 1 increased regulatory T cell number 0.000866145658363131 0.0101389991773096 1.85019072475407 0.647058823529412 24.1 24 1 pancytopenia 0.000866145658363131 0.0101389991773096 1.85019072475407 0.647058823529412 24.1 24 1 abnormal circulating chemokine level 0.000866145658363131 0.0101389991773096 1.85019072475407 0.647058823529412 24.1 24 1 abnormal cell cycle 5.08562138138653e-18 1.05420693218325e-15 1.83995251520997 0.643478260869565 24.1 24 1 lymphoid hyperplasia 2.18785098910064e-05 0.000479495976686153 1.83817649926865 0.642857142857143 24.1 24 1 abnormal sagittal suture morphology 0.00281571250316178 0.026335553418992 1.83817649926865 0.642857142857143 24.1 24 1 increased stomach tumor incidence 0.00281571250316178 0.026335553418992 1.83817649926865 0.642857142857143 24.1 24 1 decreased compact bone area 0.00281571250316178 0.026335553418992 1.83817649926865 0.642857142857143 24.1 24 1 abnormal vitelline vein topology 0.00281571250316178 0.026335553418992 1.83817649926865 0.642857142857143 24.1 24 1 increased embryonic tissue cell apoptosis 1.5002467627359e-12 1.52320972339002e-10 1.83293952918526 0.641025641025641 24.1 24 1 abnormal leukocyte adhesion 5.93343059743431e-07 1.89223187322024e-05 1.83293952918526 0.641025641025641 24.1 24 1 decreased double-positive T cell number 1.30200070374945e-15 2.23641130191891e-13 1.83000682593857 0.64 24.1 24 1 increased pre-B cell number 6.86402973724382e-05 0.00127419955010403 1.83000682593857 0.64 24.1 24 1 abnormal myelopoiesis 1.56824450681852e-07 5.65363508798704e-06 1.8196090598821 0.636363636363636 24.1 24 1 abnormal vascular branching morphogenesis 0.00021650064307909 0.00332435401024219 1.8196090598821 0.636363636363636 24.1 24 1 delayed hepatic development 0.00931974730804116 0.0689966411570011 1.8196090598821 0.636363636363636 24.1 24 1 abnormal proximal-distal axis patterning 0.00931974730804116 0.0689966411570011 1.8196090598821 0.636363636363636 24.1 24 1 loss of cortex neurons 0.00931974730804116 0.0689966411570011 1.8196090598821 0.636363636363636 24.1 24 1 abnormal dorsal-ventral polarity of the somites 0.00931974730804116 0.0689966411570011 1.8196090598821 0.636363636363636 24.1 24 1 decreased embryonic cilium length 0.00931974730804116 0.0689966411570011 1.8196090598821 0.636363636363636 24.1 24 1 abnormal T cell subpopulation ratio 5.68084180601194e-06 0.000144194836657701 1.8196090598821 0.636363636363636 24.1 24 1 pale liver 1.13559126177926e-11 1.04621602358367e-09 1.81609630107924 0.635135135135135 24.1 24 1 abnormal leukocyte migration 1.35899084654039e-08 6.26016616809114e-07 1.81461013389341 0.634615384615385 24.1 24 1 increased malignant tumor incidence 0.000687477169874746 0.00836234454798744 1.80592778875516 0.631578947368421 24.1 24 1 increased liver adenoma incidence 0.000687477169874746 0.00836234454798744 1.80592778875516 0.631578947368421 24.1 24 1 abnormal blastocyst morphology 0.000687477169874746 0.00836234454798744 1.80592778875516 0.631578947368421 24.1 24 1 failure to gastrulate 1.27063019732121e-07 4.71745166542761e-06 1.8026561804422 0.630434782608696 24.1 24 1 abnormal eye muscle morphology 5.4977032874039e-05 0.00105602601756117 1.8003539375553 0.62962962962963 24.1 24 1 impaired somite development 0.00220205956146574 0.0213170494025721 1.78711604095563 0.625 24.1 24 1 embryonic lethality between somite formation and embryo turning, incomplete penetrance 0.00220205956146574 0.0213170494025721 1.78711604095563 0.625 24.1 24 1 decreased fibroblast apoptosis 0.00220205956146574 0.0213170494025721 1.78711604095563 0.625 24.1 24 1 abnormal ear pigmentation 0.0317183745765642 0.172835611739767 1.78711604095563 0.625 24.1 24 1 schistocytosis 0.0317183745765642 0.172835611739767 1.78711604095563 0.625 24.1 24 1 abnormal cecum morphology 0.0317183745765642 0.172835611739767 1.78711604095563 0.625 24.1 24 1 enlarged pituitary gland 0.0317183745765642 0.172835611739767 1.78711604095563 0.625 24.1 24 1 poor grooming 0.0317183745765642 0.172835611739767 1.78711604095563 0.625 24.1 24 1 abnormal erythrocyte cell number 0.0317183745765642 0.172835611739767 1.78711604095563 0.625 24.1 24 1 increased cardiac output 0.0317183745765642 0.172835611739767 1.78711604095563 0.625 24.1 24 1 abnormal platelet shape 0.0317183745765642 0.172835611739767 1.78711604095563 0.625 24.1 24 1 lymph node inflammation 0.0317183745765642 0.172835611739767 1.78711604095563 0.625 24.1 24 1 abnormal extraembryonic tissue physiology 0.0317183745765642 0.172835611739767 1.78711604095563 0.625 24.1 24 1 decreased susceptibility to autoimmune disorder 0.0317183745765642 0.172835611739767 1.78711604095563 0.625 24.1 24 1 abnormal mast cell differentiation 0.0317183745765642 0.172835611739767 1.78711604095563 0.625 24.1 24 1 stomach epithelial hyperplasia 0.0317183745765642 0.172835611739767 1.78711604095563 0.625 24.1 24 1 abnormal epidermal lamellar body morphology 0.0317183745765642 0.172835611739767 1.78711604095563 0.625 24.1 24 1 abnormal base-excision repair 0.0317183745765642 0.172835611739767 1.78711604095563 0.625 24.1 24 1 abnormal olfactory bulb mitral cell layer morphology 0.0317183745765642 0.172835611739767 1.78711604095563 0.625 24.1 24 1 increased caudal vertebrae number 0.0317183745765642 0.172835611739767 1.78711604095563 0.625 24.1 24 1 increased susceptibility to parasitic infection induced morbidity/mortality 0.0317183745765642 0.172835611739767 1.78711604095563 0.625 24.1 24 1 lung situs inversus 0.0317183745765642 0.172835611739767 1.78711604095563 0.625 24.1 24 1 abnormal macrophage activation involved in immune response 0.0317183745765642 0.172835611739767 1.78711604095563 0.625 24.1 24 1 decreased cranium length 0.0317183745765642 0.172835611739767 1.78711604095563 0.625 24.1 24 1 absent hypoglossal canal 0.0317183745765642 0.172835611739767 1.78711604095563 0.625 24.1 24 1 abnormal chromosome morphology 3.65544980620438e-06 9.57150672940357e-05 1.77745595424776 0.621621621621622 24.1 24 1 skin inflammation 3.65544980620438e-06 9.57150672940357e-05 1.77745595424776 0.621621621621622 24.1 24 1 increased mortality induced by gamma-irradiation 4.36843909272352e-05 0.000876330019608852 1.77479110274214 0.620689655172414 24.1 24 1 increased acute inflammation 0.000540152327735861 0.00678145829239314 1.77009588818463 0.619047619047619 24.1 24 1 absent segment of posterior cerebral artery 0.000540152327735861 0.00678145829239314 1.77009588818463 0.619047619047619 24.1 24 1 abnormal platelet physiology 2.16692409811393e-08 9.54021892753699e-07 1.76762022959975 0.618181818181818 24.1 24 1 decreased cytotoxic T cell cytolysis 1.12227685889878e-05 0.000260903148272029 1.76609114635615 0.617647058823529 24.1 24 1 seminiferous tubule degeneration 1.34309070026177e-10 1.01240548997004e-08 1.7626349992987 0.616438356164384 24.1 24 1 decreased B-1 B cell number 2.90694325235066e-06 7.85980580458943e-05 1.75962194801785 0.615384615384615 24.1 24 1 abnormal Mullerian duct morphology 0.000135488437657742 0.00230052893292583 1.75962194801785 0.615384615384615 24.1 24 1 lymphoid hypoplasia 0.00713570075106754 0.0542815156522339 1.75962194801785 0.615384615384615 24.1 24 1 abnormal tail bud morphology 0.00713570075106754 0.0542815156522339 1.75962194801785 0.615384615384615 24.1 24 1 increased prostaglandin level 0.00713570075106754 0.0542815156522339 1.75962194801785 0.615384615384615 24.1 24 1 osteopetrosis 3.44928448096781e-05 0.000714275461214392 1.75252669822746 0.612903225806452 24.1 24 1 increased sarcoma incidence 1.98478475246471e-07 7.003052584051e-06 1.75064428501776 0.612244897959184 24.1 24 1 abnormal pharyngeal arch morphology 8.87424918849991e-06 0.000213282075907184 1.74740235115662 0.611111111111111 24.1 24 1 abnormal trophoblast giant cell morphology 8.87424918849991e-06 0.000213282075907184 1.74740235115662 0.611111111111111 24.1 24 1 abnormal Peyer's patch follicle morphology 0.0017062524596435 0.0172182677215546 1.74740235115662 0.611111111111111 24.1 24 1 decreased lactate dehydrogenase level 0.0017062524596435 0.0172182677215546 1.74740235115662 0.611111111111111 24.1 24 1 increased gastrointestinal tumor incidence 0.0017062524596435 0.0172182677215546 1.74740235115662 0.611111111111111 24.1 24 1 abnormal aerobic respiration 0.0017062524596435 0.0172182677215546 1.74740235115662 0.611111111111111 24.1 24 1 embryonic lethality between implantation and placentation, complete penetrance 6.00298000898977e-07 1.90221818756205e-05 1.74049562249592 0.608695652173913 24.1 24 1 embryonic lethality between implantation and somite formation, complete penetrance 8.51207224362884e-31 5.29344492650668e-28 1.73897332311764 0.608163265306122 24.1 24 1 embryonic lethality before implantation, complete penetrance 2.00905492631876e-16 3.84424933016762e-14 1.73850648464164 0.608 24.1 24 1 reddish skin 0.000106129295665999 0.00186430918720311 1.73605558264261 0.607142857142857 24.1 24 1 failure of blastocyst to hatch from the zona pellucida 0.000106129295665999 0.00186430918720311 1.73605558264261 0.607142857142857 24.1 24 1 premature aging 0.000106129295665999 0.00186430918720311 1.73605558264261 0.607142857142857 24.1 24 1 decreased embryo size 2.00042326417602e-58 4.97605286963784e-55 1.73477373013266 0.606694560669456 24.1 24 1 vertebral transformation 4.73924437231493e-07 1.57184938348445e-05 1.72754550625711 0.604166666666667 24.1 24 1 small liver 1.61484130384319e-10 1.1990799233761e-08 1.72296315743415 0.602564102564103 24.1 24 1 spontaneous skin ulceration 0.000326883614470047 0.00464612081929155 1.71563139931741 0.6 24.1 24 1 abnormal preimplantation embryo development 0.000326883614470047 0.00464612081929155 1.71563139931741 0.6 24.1 24 1 thrombocytopenia 4.58069897810455e-18 9.90825105046527e-16 1.71563139931741 0.6 24.1 24 1 abnormal Peyer's patch T cell area morphology 0.00131398040357449 0.0141494643025608 1.71563139931741 0.6 24.1 24 1 spleen atrophy 0.00131398040357449 0.0141494643025608 1.71563139931741 0.6 24.1 24 1 dilated vasculature 0.00131398040357449 0.0141494643025608 1.71563139931741 0.6 24.1 24 1 retarded hair growth 0.0234996453225733 0.137058306541386 1.71563139931741 0.6 24.1 24 1 increased cranium width 0.0234996453225733 0.137058306541386 1.71563139931741 0.6 24.1 24 1 absent trophoblast giant cells 0.0234996453225733 0.137058306541386 1.71563139931741 0.6 24.1 24 1 abnormal mammary gland physiology 0.0234996453225733 0.137058306541386 1.71563139931741 0.6 24.1 24 1 acrania 0.0234996453225733 0.137058306541386 1.71563139931741 0.6 24.1 24 1 peritoneal inflammation 0.0234996453225733 0.137058306541386 1.71563139931741 0.6 24.1 24 1 increased susceptibility to atherosclerosis 0.0234996453225733 0.137058306541386 1.71563139931741 0.6 24.1 24 1 tachypnea 0.0234996453225733 0.137058306541386 1.71563139931741 0.6 24.1 24 1 increased platelet aggregation 0.0234996453225733 0.137058306541386 1.71563139931741 0.6 24.1 24 1 absent axillary lymph nodes 0.0234996453225733 0.137058306541386 1.71563139931741 0.6 24.1 24 1 increased circulating fructosamine level 0.0234996453225733 0.137058306541386 1.71563139931741 0.6 24.1 24 1 aorta stenosis 0.0234996453225733 0.137058306541386 1.71563139931741 0.6 24.1 24 1 increased metastatic potential 8.27438523249881e-05 0.00149691151024297 1.71563139931741 0.6 24.1 24 1 abnormal brain vasculature morphology 8.27438523249881e-05 0.00149691151024297 1.71563139931741 0.6 24.1 24 1 macrocytosis 0.00542622029389959 0.0434709274752826 1.71563139931741 0.6 24.1 24 1 decreased hepatocyte number 0.00542622029389959 0.0434709274752826 1.71563139931741 0.6 24.1 24 1 audiogenic seizures 0.00542622029389959 0.0434709274752826 1.71563139931741 0.6 24.1 24 1 increased eosinophil cell number 2.03274905430241e-08 9.20305097709958e-07 1.70640757458989 0.596774193548387 24.1 24 1 kinked neural tube 2.92797677620217e-07 1.00459892838661e-05 1.70463376214229 0.596153846153846 24.1 24 1 increased cellular sensitivity to gamma-irradiation 1.11732590293076e-06 3.36890688913972e-05 1.70346380074069 0.595744680851064 24.1 24 1 abnormal spongiotrophoblast layer morphology 6.42720662410452e-05 0.00120661709263849 1.69776023890785 0.59375 24.1 24 1 abnormal atrioventricular cushion morphology 0.000252595935524947 0.003762469398912 1.69445076475793 0.592592592592593 24.1 24 1 anemia 1.33763403385351e-24 6.04975392583746e-22 1.69394885398638 0.592417061611374 24.1 24 1 decreased erythrocyte cell number 1.11355631517864e-18 2.6380679371494e-16 1.69377622225604 0.592356687898089 24.1 24 1 abnormal germ layer development 0.00100764920557342 0.0115508175062851 1.68963698417623 0.590909090909091 24.1 24 1 intestinal inflammation 0.00100764920557342 0.0115508175062851 1.68963698417623 0.590909090909091 24.1 24 1 increased skin papilloma incidence 0.00100764920557342 0.0115508175062851 1.68963698417623 0.590909090909091 24.1 24 1 abnormal chorion morphology 0.00100764920557342 0.0115508175062851 1.68963698417623 0.590909090909091 24.1 24 1 increased adenoma incidence 0.00100764920557342 0.0115508175062851 1.68963698417623 0.590909090909091 24.1 24 1 pale yolk sac 1.84170300254052e-10 1.34742241729986e-08 1.68807105555327 0.590361445783133 24.1 24 1 increased monocyte cell number 2.75238363006591e-12 2.5836053885996e-10 1.68703754266212 0.59 24.1 24 1 decreased cell proliferation 2.21784098031172e-21 6.89609929815675e-19 1.68471912185223 0.589189189189189 24.1 24 1 decreased bone marrow cell number 2.59974101637454e-09 1.43707906182926e-07 1.68429566599654 0.589041095890411 24.1 24 1 increased tumor incidence 8.74163797120115e-15 1.27910732078605e-12 1.68334801277111 0.588709677419355 24.1 24 1 pallor 3.07464562897663e-20 8.99786000244631e-18 1.68295270599707 0.588571428571429 24.1 24 1 abnormal extraembryonic tissue morphology 2.15988523121281e-12 2.06642865870841e-10 1.68199156795824 0.588235294117647 24.1 24 1 pericardial edema 9.79098481324315e-09 4.63906185198902e-07 1.68199156795824 0.588235294117647 24.1 24 1 increased lung adenocarcinoma incidence 6.81100764523014e-07 2.11510291526706e-05 1.68199156795824 0.588235294117647 24.1 24 1 enlarged liver sinusoidal spaces 4.97749534099248e-05 0.000978776257764332 1.68199156795824 0.588235294117647 24.1 24 1 abnormal direction of heart looping 4.97749534099248e-05 0.000978776257764332 1.68199156795824 0.588235294117647 24.1 24 1 abnormal interatrial septum morphology 0.00411050799446945 0.0355030855425096 1.68199156795824 0.588235294117647 24.1 24 1 abnormal melanosome morphology 0.00411050799446945 0.0355030855425096 1.68199156795824 0.588235294117647 24.1 24 1 increased brain size 0.00411050799446945 0.0355030855425096 1.68199156795824 0.588235294117647 24.1 24 1 abnormal ductus venosus valve morphology 0.00411050799446945 0.0355030855425096 1.68199156795824 0.588235294117647 24.1 24 1 preweaning lethality, complete penetrance 3.06494403523981e-81 1.52480965753181e-77 1.68085508716908 0.587837837837838 24.1 24 1 abnormal allantois morphology 2.59914214845495e-06 7.1796648228035e-05 1.67833506454964 0.58695652173913 24.1 24 1 abnormal embryonic neuroepithelium morphology 1.39758765501034e-07 5.11249895858562e-06 1.67619159703425 0.586206896551724 24.1 24 1 abnormal microglial cell morphology 0.000194592910712581 0.00304433877608519 1.67619159703425 0.586206896551724 24.1 24 1 decreased granulocyte number 0.000194592910712581 0.00304433877608519 1.67619159703425 0.586206896551724 24.1 24 1 increased spleen weight 2.78169716628217e-13 3.21835893075669e-11 1.67008366305234 0.584070796460177 24.1 24 1 abnormal osteoclast morphology 2.01808795490973e-06 5.80346102640226e-05 1.66797497155859 0.583333333333333 24.1 24 1 increased hemangiosarcoma incidence 0.000770464181841994 0.00919198874020124 1.66797497155859 0.583333333333333 24.1 24 1 abnormal cellular extravasation 0.000770464181841994 0.00919198874020124 1.66797497155859 0.583333333333333 24.1 24 1 abnormal mating frequency 0.0173999434909572 0.109853704146589 1.66797497155859 0.583333333333333 24.1 24 1 abnormal embryonic growth/weight/body size 0.0173999434909572 0.109853704146589 1.66797497155859 0.583333333333333 24.1 24 1 abnormal vascular endothelial cell development 0.0173999434909572 0.109853704146589 1.66797497155859 0.583333333333333 24.1 24 1 abnormal nucleotide metabolism 0.0173999434909572 0.109853704146589 1.66797497155859 0.583333333333333 24.1 24 1 abnormal inflammatory response 5.96724116252925e-09 2.99868937207909e-07 1.66797497155859 0.583333333333333 24.1 24 1 embryonic lethality, complete penetrance 1.29703174525955e-34 1.29054658653325e-31 1.66722800560626 0.58307210031348 24.1 24 1 abnormal response to infection 1.23935148888552e-09 7.51923616732375e-08 1.6649587419536 0.582278481012658 24.1 24 1 decreased circulating total protein level 4.11967836259239e-07 1.38482431445251e-05 1.66364256903506 0.581818181818182 24.1 24 1 abnormal T cell activation 4.64904347500013e-09 2.38443209155934e-07 1.66153491375334 0.581081081081081 24.1 24 1 embryonic growth arrest 6.19106645223202e-25 3.42228395553937e-22 1.66069123805833 0.580786026200873 24.1 24 1 decreased double-negative T cell number 0.000149552939653879 0.00248838085210049 1.66028845095233 0.580645161290323 24.1 24 1 abnormal mitochondrial ATP synthesis coupled electron transport 0.000149552939653879 0.00248838085210049 1.66028845095233 0.580645161290323 24.1 24 1 enlarged spleen 7.99088408279664e-31 5.29344492650668e-28 1.65804654910884 0.579861111111111 24.1 24 1 increased inflammatory response 4.19653478049744e-11 3.42258369393029e-09 1.6554338063589 0.578947368421053 24.1 24 1 small superior vagus ganglion 0.00310706848307553 0.028785224773372 1.6554338063589 0.578947368421053 24.1 24 1 trabecula carnea hypoplasia 5.9612812617208e-06 0.00014903203154302 1.65208949563898 0.577777777777778 24.1 24 1 decreased bone resorption 0.00058787703739592 0.00725729097033425 1.64964557626674 0.576923076923077 24.1 24 1 decreased neutrophil cell number 6.72359395376034e-13 6.96872498332452e-11 1.6374259794055 0.572649572649573 24.1 24 1 increased neutrophil cell number 1.303636738807e-15 2.23641130191891e-13 1.63675179475109 0.572413793103448 24.1 24 1 abnormal somite shape 0.00044788478867021 0.00597379845478364 1.63393466601658 0.571428571428571 24.1 24 1 abnormal brainstem morphology 0.00044788478867021 0.00597379845478364 1.63393466601658 0.571428571428571 24.1 24 1 abnormal mitotic spindle morphology 0.00044788478867021 0.00597379845478364 1.63393466601658 0.571428571428571 24.1 24 1 abnormal antigen presentation 0.0128956850816086 0.0897287178755281 1.63393466601658 0.571428571428571 24.1 24 1 amyloid beta deposits 0.0128956850816086 0.0897287178755281 1.63393466601658 0.571428571428571 24.1 24 1 abnormal vascular endothelial cell migration 0.0128956850816086 0.0897287178755281 1.63393466601658 0.571428571428571 24.1 24 1 abnormal maternal decidual layer morphology 0.0128956850816086 0.0897287178755281 1.63393466601658 0.571428571428571 24.1 24 1 abnormal viscerocranium morphology 0.0128956850816086 0.0897287178755281 1.63393466601658 0.571428571428571 24.1 24 1 abnormal spleen white pulp morphology 1.75433394769466e-05 0.000389634437043791 1.63393466601658 0.571428571428571 24.1 24 1 increased carcinoma incidence 8.787590286215e-05 0.00157259934078848 1.63393466601658 0.571428571428571 24.1 24 1 abnormal eye pigmentation 0.00234575117135932 0.0223994473656672 1.63393466601658 0.571428571428571 24.1 24 1 left pulmonary isomerism 0.00234575117135932 0.0223994473656672 1.63393466601658 0.571428571428571 24.1 24 1 increased muscle cell glucose uptake 0.00234575117135932 0.0223994473656672 1.63393466601658 0.571428571428571 24.1 24 1 abnormal definitive hematopoiesis 2.11790786733221e-10 1.52704226666344e-08 1.62954236852729 0.56989247311828 24.1 24 1 abnormal trophoblast layer morphology 2.72834378306464e-06 7.41721875450633e-05 1.62592518235963 0.568627450980392 24.1 24 1 embryonic lethality during organogenesis, complete penetrance 8.86164119844082e-55 1.46955549874144e-51 1.62372257435397 0.567857142857143 24.1 24 1 decreased T cell proliferation 1.74819220587364e-15 2.89908540807379e-13 1.62289456692187 0.567567567567568 24.1 24 1 internal hemorrhage 8.83071212927197e-08 3.35364830863573e-06 1.62174112373287 0.567164179104478 24.1 24 1 salivary gland inflammation 0.000340857063988664 0.00475003891692886 1.62031854379977 0.566666666666667 24.1 24 1 abnormal spleen marginal zone morphology 0.000340857063988664 0.00475003891692886 1.62031854379977 0.566666666666667 24.1 24 1 abnormal neural tube closure 2.92397670581834e-09 1.58117218602677e-07 1.61917019614293 0.566265060240964 24.1 24 1 thymus hypoplasia 2.37620695445722e-14 3.19503502660126e-12 1.61617450660335 0.565217391304348 24.1 24 1 abnormal myelin sheath morphology 1.03320621089664e-05 0.00024132398587844 1.61617450660335 0.565217391304348 24.1 24 1 pancreas inflammation 0.00176987237596074 0.0176711136156942 1.61617450660335 0.565217391304348 24.1 24 1 dilated heart 0.00176987237596074 0.0176711136156942 1.61617450660335 0.565217391304348 24.1 24 1 impaired macrophage chemotaxis 5.13887102080423e-05 0.000990925710407017 1.61298678568303 0.564102564102564 24.1 24 1 abnormal embryo turning 1.61215344248498e-06 4.69032945986129e-05 1.61165373875272 0.563636363636364 24.1 24 1 abnormal T-helper 2 physiology 1.61215344248498e-06 4.69032945986129e-05 1.61165373875272 0.563636363636364 24.1 24 1 neonatal lethality 0.000259199776898951 0.00382344161589661 1.60840443686007 0.5625 24.1 24 1 failure of tooth eruption 0.00957156980702887 0.0701144851584421 1.60840443686007 0.5625 24.1 24 1 intraventricular hemorrhage 0.00957156980702887 0.0701144851584421 1.60840443686007 0.5625 24.1 24 1 increased intestinal adenocarcinoma incidence 0.00957156980702887 0.0701144851584421 1.60840443686007 0.5625 24.1 24 1 astrocytosis 4.03927897750551e-08 1.68869016076386e-06 1.60595633269438 0.561643835616438 24.1 24 1 incomplete embryo turning 1.2378255139144e-06 3.70974815164106e-05 1.60526914556015 0.56140350877193 24.1 24 1 Leydig cell hyperplasia 3.9248980141298e-05 0.000793754781312835 1.60404561724798 0.560975609756098 24.1 24 1 abnormal dendritic cell physiology 3.49164415267683e-11 2.94422536602834e-09 1.60339383113776 0.560747663551402 24.1 24 1 abnormal B cell differentiation 1.03593251503853e-09 6.36267192878603e-08 1.60251284551626 0.56043956043956 24.1 24 1 abnormal egg cylinder morphology 0.00133502126758811 0.0142832920564535 1.60125597269625 0.56 24.1 24 1 increased cellular sensitivity to ionizing radiation 0.00133502126758811 0.0142832920564535 1.60125597269625 0.56 24.1 24 1 decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 0.00133502126758811 0.0142832920564535 1.60125597269625 0.56 24.1 24 1 abnormal brown adipose tissue morphology 0.000196992052593131 0.00306261081765883 1.59789198956033 0.558823529411765 24.1 24 1 abnormal vasculogenesis 2.99584407597012e-05 0.000631539164319972 1.59593618541154 0.558139534883721 24.1 24 1 oxidative stress 2.26308766649323e-09 1.2794160387277e-07 1.58854759196056 0.555555555555556 24.1 24 1 abnormal thymus medulla morphology 0.00711582741300187 0.0542815156522339 1.58854759196056 0.555555555555556 24.1 24 1 increased circulating glycerol level 0.00711582741300187 0.0542815156522339 1.58854759196056 0.555555555555556 24.1 24 1 darkened coat color 0.00711582741300187 0.0542815156522339 1.58854759196056 0.555555555555556 24.1 24 1 increased effector memory CD4-positive, alpha-beta T cell number 0.00711582741300187 0.0542815156522339 1.58854759196056 0.555555555555556 24.1 24 1 heart hyperplasia 0.0563440661260914 0.256460868231752 1.58854759196056 0.555555555555556 24.1 24 1 crypts of Lieberkuhn abscesses 0.0563440661260914 0.256460868231752 1.58854759196056 0.555555555555556 24.1 24 1 abnormal sympathetic neuron morphology 0.0563440661260914 0.256460868231752 1.58854759196056 0.555555555555556 24.1 24 1 psoriasis 0.0563440661260914 0.256460868231752 1.58854759196056 0.555555555555556 24.1 24 1 increased pheochromocytoma incidence 0.0563440661260914 0.256460868231752 1.58854759196056 0.555555555555556 24.1 24 1 genetic imprinting 0.0563440661260914 0.256460868231752 1.58854759196056 0.555555555555556 24.1 24 1 enlarged otoliths 0.0563440661260914 0.256460868231752 1.58854759196056 0.555555555555556 24.1 24 1 short frontal bone 0.0563440661260914 0.256460868231752 1.58854759196056 0.555555555555556 24.1 24 1 liver hyperplasia 0.0563440661260914 0.256460868231752 1.58854759196056 0.555555555555556 24.1 24 1 abnormal inguinal fat pad morphology 0.0563440661260914 0.256460868231752 1.58854759196056 0.555555555555556 24.1 24 1 abnormal optic chiasm morphology 0.0563440661260914 0.256460868231752 1.58854759196056 0.555555555555556 24.1 24 1 multiflagellated sperm 0.0563440661260914 0.256460868231752 1.58854759196056 0.555555555555556 24.1 24 1 eye opacity 0.0563440661260914 0.256460868231752 1.58854759196056 0.555555555555556 24.1 24 1 axonal spheroids 0.0563440661260914 0.256460868231752 1.58854759196056 0.555555555555556 24.1 24 1 abnormal ventricle myocardium morphology 0.0563440661260914 0.256460868231752 1.58854759196056 0.555555555555556 24.1 24 1 shortened ST segment 0.0563440661260914 0.256460868231752 1.58854759196056 0.555555555555556 24.1 24 1 abnormal oxidative phosphorylation 0.0563440661260914 0.256460868231752 1.58854759196056 0.555555555555556 24.1 24 1 increased core body temperature 0.0563440661260914 0.256460868231752 1.58854759196056 0.555555555555556 24.1 24 1 abnormal ductus venosus valve topology 0.0563440661260914 0.256460868231752 1.58854759196056 0.555555555555556 24.1 24 1 symmetric azygos veins 0.0563440661260914 0.256460868231752 1.58854759196056 0.555555555555556 24.1 24 1 enhanced leukocyte tethering or rolling 0.0563440661260914 0.256460868231752 1.58854759196056 0.555555555555556 24.1 24 1 increased endoplasmic reticulum stress 0.0563440661260914 0.256460868231752 1.58854759196056 0.555555555555556 24.1 24 1 decreased monocyte cell number 4.27726989554887e-07 1.42814884096346e-05 1.58365975321607 0.553846153846154 24.1 24 1 dermatitis 2.07566329981885e-06 5.93472696356252e-05 1.57759209132635 0.551724137931034 24.1 24 1 decreased trophoblast giant cell number 0.000759628638464214 0.00910639150929992 1.57759209132635 0.551724137931034 24.1 24 1 polychromatophilia 0.000759628638464214 0.00910639150929992 1.57759209132635 0.551724137931034 24.1 24 1 abnormal embryo development 4.15117512433844e-13 4.48958613990951e-11 1.57686709496085 0.551470588235294 24.1 24 1 abnormal vascular regression 0.00529862058024347 0.0427932425108949 1.57266211604096 0.55 24.1 24 1 small gonad 0.00529862058024347 0.0427932425108949 1.57266211604096 0.55 24.1 24 1 abnormal physiological neovascularization 0.00529862058024347 0.0427932425108949 1.57266211604096 0.55 24.1 24 1 abnormal thymocyte activation 0.00529862058024347 0.0427932425108949 1.57266211604096 0.55 24.1 24 1 abnormal optic stalk morphology 0.00529862058024347 0.0427932425108949 1.57266211604096 0.55 24.1 24 1 abnormal sperm mitochondrial sheath morphology 0.00529862058024347 0.0427932425108949 1.57266211604096 0.55 24.1 24 1 failure of chorioallantoic fusion 1.01263997846075e-05 0.00024132398587844 1.56985879676103 0.549019607843137 24.1 24 1 abnormal developmental patterning 2.3441761724984e-08 1.02300670685785e-06 1.56917506035129 0.548780487804878 24.1 24 1 pale kidney 0.000573154929252332 0.00711083733922781 1.5680502036772 0.548387096774194 24.1 24 1 lethality throughout fetal growth and development, complete penetrance 2.72194712096037e-17 5.41667477071114e-15 1.56513741692114 0.547368421052632 24.1 24 1 muscular atrophy 4.97447908597636e-05 0.000978776257764332 1.55966490847037 0.545454545454545 24.1 24 1 abnormal abdominal fat pad morphology 0.00395147353030241 0.0346019751949997 1.55966490847037 0.545454545454545 24.1 24 1 increased myocardial infarction size 0.00395147353030241 0.0346019751949997 1.55966490847037 0.545454545454545 24.1 24 1 decreased susceptibility to viral infection induced morbidity/mortality 0.00395147353030241 0.0346019751949997 1.55966490847037 0.545454545454545 24.1 24 1 pulmonary vascular congestion 0.00395147353030241 0.0346019751949997 1.55966490847037 0.545454545454545 24.1 24 1 impaired humoral immune response 0.00395147353030241 0.0346019751949997 1.55966490847037 0.545454545454545 24.1 24 1 premature suture closure 0.040515522940012 0.210182196690886 1.55966490847037 0.545454545454545 24.1 24 1 abnormal hemoglobin 0.040515522940012 0.210182196690886 1.55966490847037 0.545454545454545 24.1 24 1 vasculitis 0.040515522940012 0.210182196690886 1.55966490847037 0.545454545454545 24.1 24 1 fatigue 0.040515522940012 0.210182196690886 1.55966490847037 0.545454545454545 24.1 24 1 abnormal coronal suture morphology 0.040515522940012 0.210182196690886 1.55966490847037 0.545454545454545 24.1 24 1 increased glycogen level 0.040515522940012 0.210182196690886 1.55966490847037 0.545454545454545 24.1 24 1 abnormal pulmonary alveolar sac morphology 0.040515522940012 0.210182196690886 1.55966490847037 0.545454545454545 24.1 24 1 chylous ascites 0.040515522940012 0.210182196690886 1.55966490847037 0.545454545454545 24.1 24 1 decreased circulating serum albumin level 1.29740075599747e-09 7.68401042986596e-08 1.55966490847037 0.545454545454545 24.1 24 1 increased leukocyte cell number 2.37664268750064e-13 2.81518985007517e-11 1.55787219018477 0.544827586206897 24.1 24 1 abnormal placenta morphology 6.56624767287728e-08 2.59262556925115e-06 1.55637447617402 0.544303797468354 24.1 24 1 abnormal placenta labyrinth morphology 6.56624767287728e-08 2.59262556925115e-06 1.55637447617402 0.544303797468354 24.1 24 1 decreased mean corpuscular hemoglobin 5.39306983674785e-07 1.75362891750461e-05 1.55584220036137 0.544117647058823 24.1 24 1 impaired natural killer cell mediated cytotoxicity 4.47735654430896e-06 0.000116014837541339 1.55510448476139 0.543859649122807 24.1 24 1 abnormal cell death 3.7764318915504e-05 0.000773158381089023 1.55401394865707 0.543478260869565 24.1 24 1 abnormal immune system morphology 3.7764318915504e-05 0.000773158381089023 1.55401394865707 0.543478260869565 24.1 24 1 abnormal liver development 0.000326567480398674 0.00464612081929155 1.55223793271575 0.542857142857143 24.1 24 1 abnormal dermal layer morphology 0.000326567480398674 0.00464612081929155 1.55223793271575 0.542857142857143 24.1 24 1 abnormal embryonic epiblast morphology 0.000326567480398674 0.00464612081929155 1.55223793271575 0.542857142857143 24.1 24 1 increased T cell proliferation 4.46153125300858e-10 2.9994754032051e-08 1.54994737009984 0.542056074766355 24.1 24 1 thymus atrophy 2.86693572266513e-05 0.000609530137617907 1.54883390216155 0.541666666666667 24.1 24 1 hemolytic anemia 0.00295099115082836 0.0274928482684852 1.54883390216155 0.541666666666667 24.1 24 1 increased body temperature 0.00295099115082836 0.0274928482684852 1.54883390216155 0.541666666666667 24.1 24 1 increased erythroid progenitor cell number 0.000246619142787849 0.00369557299810105 1.54561387325892 0.540540540540541 24.1 24 1 increased grip strength 1.30678930243402e-08 6.07595960711145e-07 1.53966920451562 0.538461538461538 24.1 24 1 increased hepatocyte apoptosis 0.000186304323230845 0.0029707179745944 1.53966920451562 0.538461538461538 24.1 24 1 failure of heart looping 0.000186304323230845 0.0029707179745944 1.53966920451562 0.538461538461538 24.1 24 1 heart inflammation 0.00220668953614565 0.0213170494025721 1.53966920451562 0.538461538461538 24.1 24 1 increased leukemia incidence 0.00220668953614565 0.0213170494025721 1.53966920451562 0.538461538461538 24.1 24 1 decreased Peyer's patch number 0.00220668953614565 0.0213170494025721 1.53966920451562 0.538461538461538 24.1 24 1 absent common myeloid progenitor cells 0.0293748933541617 0.165130050211248 1.53966920451562 0.538461538461538 24.1 24 1 abnormal coping response 0.0293748933541617 0.165130050211248 1.53966920451562 0.538461538461538 24.1 24 1 axonal dystrophy 0.0293748933541617 0.165130050211248 1.53966920451562 0.538461538461538 24.1 24 1 orthokeratosis 0.0293748933541617 0.165130050211248 1.53966920451562 0.538461538461538 24.1 24 1 empty decidua capsularis 0.0293748933541617 0.165130050211248 1.53966920451562 0.538461538461538 24.1 24 1 abnormal embryonic tissue morphology 6.24022237879145e-13 6.60534177329521e-11 1.53667665018226 0.537414965986395 24.1 24 1 diluted coat color 1.25468629033523e-05 0.000287652732461649 1.53559600556188 0.537037037037037 24.1 24 1 decreased tumor growth/size 1.25468629033523e-05 0.000287652732461649 1.53559600556188 0.537037037037037 24.1 24 1 abnormal cell adhesion 1.25468629033523e-05 0.000287652732461649 1.53559600556188 0.537037037037037 24.1 24 1 hemopericardium 0.000140786875841541 0.00236626590307996 1.53430450345459 0.536585365853659 24.1 24 1 lethality throughout fetal growth and development, incomplete penetrance 2.56907064064543e-15 3.99410201162845e-13 1.53352527313288 0.536312849162011 24.1 24 1 small superior cervical ganglion 0.00165208644480897 0.0169117902529313 1.53181374939054 0.535714285714286 24.1 24 1 impaired macrophage phagocytosis 0.000106424886264459 0.00186430918720311 1.52943884435273 0.534883720930233 24.1 24 1 thrombocytosis 7.23485619539026e-06 0.000179967047860333 1.5282923384724 0.53448275862069 24.1 24 1 increased T cell number 3.60026132269527e-08 1.51790678647534e-06 1.5271718895439 0.534090909090909 24.1 24 1 absent mesoderm 5.49456078915863e-06 0.00014074112001224 1.52500568828214 0.533333333333333 24.1 24 1 abnormal optic cup morphology 0.00123822472357913 0.0135037179332706 1.52500568828214 0.533333333333333 24.1 24 1 abnormal energy homeostasis 0.0214322162675617 0.12885294033303 1.52500568828214 0.533333333333333 24.1 24 1 liver vascular congestion 0.0214322162675617 0.12885294033303 1.52500568828214 0.533333333333333 24.1 24 1 neuron degeneration 6.08721773669053e-05 0.00114711773636498 1.5209498220899 0.531914893617021 24.1 24 1 decreased caudal vertebrae number 3.17000111484644e-06 8.52473272776272e-05 1.51904863481229 0.53125 24.1 24 1 abnormal bone marrow cavity morphology 0.0157152643461582 0.104510934621237 1.51379241116242 0.529411764705882 24.1 24 1 abnormal dorsal-ventral axis patterning 0.0157152643461582 0.104510934621237 1.51379241116242 0.529411764705882 24.1 24 1 abnormal ectoplacental cone morphology 0.0157152643461582 0.104510934621237 1.51379241116242 0.529411764705882 24.1 24 1 abnormal stationary movement 0.0115700040018089 0.0833006800419673 1.50493982396264 0.526315789473684 24.1 24 1 decreased tumor incidence 0.0115700040018089 0.0833006800419673 1.50493982396264 0.526315789473684 24.1 24 1 decreased fertilization frequency 0.0115700040018089 0.0833006800419673 1.50493982396264 0.526315789473684 24.1 24 1 decreased circulating magnesium level 0.0115700040018089 0.0833006800419673 1.50493982396264 0.526315789473684 24.1 24 1 increased hepatocellular carcinoma incidence 1.51381146131638e-05 0.000340778824436607 1.50493982396264 0.526315789473684 24.1 24 1 decreased susceptibility to induced arthritis 1.51381146131638e-05 0.000340778824436607 1.50493982396264 0.526315789473684 24.1 24 1 abnormal cytotoxic T cell physiology 0.000223575786964014 0.00341065489637077 1.49777344384853 0.523809523809524 24.1 24 1 abnormal clavicle morphology 0.00854677693001604 0.0644245685254997 1.49777344384853 0.523809523809524 24.1 24 1 decreased macrophage cell number 0.000168503085993411 0.00273062818507238 1.49467887061744 0.522727272727273 24.1 24 1 decreased blood urea nitrogen level 0.000168503085993411 0.00273062818507238 1.49467887061744 0.522727272727273 24.1 24 1 lung inflammation 5.35029688463359e-11 4.29318177436324e-09 1.49276751656294 0.522058823529412 24.1 24 1 fragile skeleton 0.00633140206231149 0.0492167582187495 1.49185339071079 0.521739130434783 24.1 24 1 increased susceptibility to fungal infection 0.00633140206231149 0.0492167582187495 1.49185339071079 0.521739130434783 24.1 24 1 abnormal primitive streak morphology 0.00470162519100529 0.0390493911940757 1.48688054607509 0.52 24.1 24 1 abnormal keratinocyte physiology 0.00470162519100529 0.0390493911940757 1.48688054607509 0.52 24.1 24 1 decreased B cell number 1.28163423551986e-15 2.23641130191891e-13 1.48521488452235 0.519417475728155 24.1 24 1 increased neuron apoptosis 5.49093089210548e-07 1.7738559213133e-05 1.48264441916319 0.518518518518518 24.1 24 1 abnormal heart valve morphology 0.00349868612843447 0.0316347465316172 1.48264441916319 0.518518518518518 24.1 24 1 abnormal spleen morphology 3.07773587756237e-13 3.47993999792563e-11 1.47899258561845 0.517241379310345 24.1 24 1 anophthalmia 1.82727620360674e-07 6.49335650924539e-06 1.47788472600376 0.51685393258427 24.1 24 1 intracranial hemorrhage 1.78564931148883e-05 0.000394826903318085 1.47734926052332 0.516666666666667 24.1 24 1 small spleen 1.38829602681652e-07 5.11249895858562e-06 1.47682556351498 0.516483516483517 24.1 24 1 abnormal immune system physiology 8.61068306755797e-10 5.56339587806505e-08 1.47581195640207 0.516129032258065 24.1 24 1 increased lung adenoma incidence 0.00194763250419438 0.0191491535738479 1.47581195640207 0.516129032258065 24.1 24 1 decreased thymus weight 0.00194763250419438 0.0191491535738479 1.47581195640207 0.516129032258065 24.1 24 1 abnormal osteoclast physiology 1.02277806949666e-05 0.00024132398587844 1.4743707337884 0.515625 24.1 24 1 decreased IgM level 6.09271865891827e-08 2.44445768775148e-06 1.47391013687062 0.515463917525773 24.1 24 1 increased mean corpuscular hemoglobin 4.63104581023517e-08 1.90408701701818e-06 1.47301685799979 0.515151515151515 24.1 24 1 prenatal lethality, complete penetrance 7.2938733037067e-20 1.90984314136531e-17 1.47083507255629 0.514388489208633 24.1 24 1 spleen hypoplasia 2.03484544217277e-08 9.20305097709958e-07 1.47054119941492 0.514285714285714 24.1 24 1 abnormal midbrain development 0.00109045287675798 0.0122460565730721 1.47054119941492 0.514285714285714 24.1 24 1 abnormal hepatocyte morphology 8.9479012360658e-09 4.28036621629109e-07 1.46833317959598 0.513513513513513 24.1 24 1 abnormal angiogenesis 2.55222031197996e-06 7.09346148162028e-05 1.46833317959598 0.513513513513513 24.1 24 1 increased circulating phosphate level 0.000817398190521813 0.00970538424306926 1.46833317959598 0.513513513513513 24.1 24 1 abnormal respiratory electron transport chain 0.000817398190521813 0.00970538424306926 1.46833317959598 0.513513513513513 24.1 24 1 abnormal embryo size 6.80537737948207e-09 3.38567524629233e-07 1.46764927965206 0.513274336283186 24.1 24 1 abnormal vitelline vasculature morphology 5.17624442054956e-09 2.62773632573817e-07 1.46698916753227 0.51304347826087 24.1 24 1 increased oxygen consumption 4.86104689369819e-07 1.60148934816787e-05 1.46294150329391 0.511627906976744 24.1 24 1 abnormal left-right axis patterning 0.000346305301982597 0.00481248289766318 1.46294150329391 0.511627906976744 24.1 24 1 abnormal myocardial trabeculae morphology 0.000260532001565618 0.00382344161589661 1.46146378460372 0.511111111111111 24.1 24 1 abnormal cell migration 0.000260532001565618 0.00382344161589661 1.46146378460372 0.511111111111111 24.1 24 1 small placenta 0.000260532001565618 0.00382344161589661 1.46146378460372 0.511111111111111 24.1 24 1 decreased leukocyte cell number 2.56176280960563e-10 1.82068142539829e-08 1.46099997508782 0.510948905109489 24.1 24 1 decreased birth body size 1.03632952487251e-08 4.86390508135919e-07 1.45477516316388 0.508771929824561 24.1 24 1 absent vitelline blood vessels 4.78716152941126e-05 0.000956471028466708 1.45477516316388 0.508771929824561 24.1 24 1 liver inflammation 4.5555865797841e-09 2.36083783691937e-07 1.45352104664391 0.508333333333333 24.1 24 1 abnormal NK cell physiology 2.73264667763584e-05 0.000583472842113232 1.45313042018687 0.508196721311475 24.1 24 1 abnormal heart development 2.5320615105822e-11 2.21000105528885e-09 1.44779021039444 0.506329113924051 24.1 24 1 abnormal somite development 2.23041315563733e-06 6.2980086603773e-05 1.44779021039444 0.506329113924051 24.1 24 1 abnormal T cell differentiation 1.07036626414976e-07 4.00381365725192e-06 1.44384820734633 0.504950495049505 24.1 24 1 decreased T cell number 2.8963916571196e-11 2.48440491278793e-09 1.43857291247112 0.503105590062112 24.1 24 1 abnormal cytokine secretion 1.28962976915251e-10 9.87062784851346e-09 1.42969283276451 0.5 24.1 24 1 short stride length 0.000223161216611622 0.00341065489637077 1.42969283276451 0.5 24.1 24 1 decreased sensitivity to induced morbidity/mortality 0.000524107517971781 0.0066516196477286 1.42969283276451 0.5 24.1 24 1 abnormal oocyte morphology 0.00221519330113284 0.0213577261107285 1.42969283276451 0.5 24.1 24 1 increased bone resorption 0.00534528581205995 0.0431001570745515 1.42969283276451 0.5 24.1 24 1 abnormal oogenesis 0.0131420803297297 0.0908081245005627 1.42969283276451 0.5 24.1 24 1 abnormal sperm midpiece morphology 0.0131420803297297 0.0908081245005627 1.42969283276451 0.5 24.1 24 1 rough coat 0.0131420803297297 0.0908081245005627 1.42969283276451 0.5 24.1 24 1 increased mammary gland tumor incidence 0.0131420803297297 0.0908081245005627 1.42969283276451 0.5 24.1 24 1 megacephaly 0.0458541016267149 0.229040316860348 1.42969283276451 0.5 24.1 24 1 translucent skin 0.0458541016267149 0.229040316860348 1.42969283276451 0.5 24.1 24 1 absent visceral yolk sac blood islands 0.0458541016267149 0.229040316860348 1.42969283276451 0.5 24.1 24 1 abnormal adrenal gland secretion 0.0458541016267149 0.229040316860348 1.42969283276451 0.5 24.1 24 1 increased lactate dehydrogenase level 0.0458541016267149 0.229040316860348 1.42969283276451 0.5 24.1 24 1 vascular smooth muscle hypoplasia 0.0458541016267149 0.229040316860348 1.42969283276451 0.5 24.1 24 1 abnormal positive T cell selection 0.0458541016267149 0.229040316860348 1.42969283276451 0.5 24.1 24 1 increased B-1 B cell number 0.0458541016267149 0.229040316860348 1.42969283276451 0.5 24.1 24 1 spina bifida occulta 0.0458541016267149 0.229040316860348 1.42969283276451 0.5 24.1 24 1 pulmonary alveolar hemorrhage 0.0458541016267149 0.229040316860348 1.42969283276451 0.5 24.1 24 1 decreased hematocrit 3.84759397914566e-10 2.65858056197912e-08 1.42969283276451 0.5 24.1 24 1 abnormal lipid homeostasis 3.43400985650174e-09 1.8370106490426e-07 1.42969283276451 0.5 24.1 24 1 increased sacral vertebrae number 3.10896268156277e-05 0.000652619803408219 1.42969283276451 0.5 24.1 24 1 distended pericardium 0.000168122315245047 0.00273062818507238 1.42969283276451 0.5 24.1 24 1 disheveled coat 0.000697782814887335 0.0084669987904012 1.42969283276451 0.5 24.1 24 1 increased bone marrow cell number 0.00124044202924717 0.0135037179332706 1.42969283276451 0.5 24.1 24 1 failure of primitive streak formation 0.0029662942398026 0.0275837641925569 1.42969283276451 0.5 24.1 24 1 abnormal erythrocyte osmotic lysis 0.0071965608458649 0.0546609010811876 1.42969283276451 0.5 24.1 24 1 ocular hypertelorism 0.00971181297379464 0.0709490007997479 1.42969283276451 0.5 24.1 24 1 abnormal pericardium morphology 0.0178413874233743 0.109954669724021 1.42969283276451 0.5 24.1 24 1 increased mammary adenocarcinoma incidence 0.0178413874233743 0.109954669724021 1.42969283276451 0.5 24.1 24 1 absent placental labyrinth 0.0178413874233743 0.109954669724021 1.42969283276451 0.5 24.1 24 1 abnormal induced retinal neovascularization 0.0178413874233743 0.109954669724021 1.42969283276451 0.5 24.1 24 1 abnormal mitral valve morphology 0.0243147012793146 0.140821465500105 1.42969283276451 0.5 24.1 24 1 abnormal iron level 0.0243147012793146 0.140821465500105 1.42969283276451 0.5 24.1 24 1 abnormal bile duct morphology 0.0243147012793146 0.140821465500105 1.42969283276451 0.5 24.1 24 1 absent allantois 0.0243147012793146 0.140821465500105 1.42969283276451 0.5 24.1 24 1 impaired leukocyte tethering or rolling 0.0243147012793146 0.140821465500105 1.42969283276451 0.5 24.1 24 1 disorganized yolk sac vascular plexus 0.0332928627280945 0.179255402675617 1.42969283276451 0.5 24.1 24 1 impaired muscle relaxation 0.0332928627280945 0.179255402675617 1.42969283276451 0.5 24.1 24 1 increased pancreatic beta cell number 0.0332928627280945 0.179255402675617 1.42969283276451 0.5 24.1 24 1 small pancreas 0.0332928627280945 0.179255402675617 1.42969283276451 0.5 24.1 24 1 blepharitis 0.0332928627280945 0.179255402675617 1.42969283276451 0.5 24.1 24 1 dystonia 0.0332928627280945 0.179255402675617 1.42969283276451 0.5 24.1 24 1 abnormal Langerhans cell physiology 0.0332928627280945 0.179255402675617 1.42969283276451 0.5 24.1 24 1 decreased midbrain size 0.0332928627280945 0.179255402675617 1.42969283276451 0.5 24.1 24 1 abnormal supraoccipital bone morphology 0.0636311023890666 0.27869639608081 1.42969283276451 0.5 24.1 24 1 amyloidosis 0.0636311023890666 0.27869639608081 1.42969283276451 0.5 24.1 24 1 abnormal pilomotor reflex 0.0636311023890666 0.27869639608081 1.42969283276451 0.5 24.1 24 1 abnormal respiratory function 0.0636311023890666 0.27869639608081 1.42969283276451 0.5 24.1 24 1 delayed somite formation 0.0636311023890666 0.27869639608081 1.42969283276451 0.5 24.1 24 1 abnormal B cell proliferation 0.0636311023890666 0.27869639608081 1.42969283276451 0.5 24.1 24 1 abnormal palatine bone morphology 0.0636311023890666 0.27869639608081 1.42969283276451 0.5 24.1 24 1 decreased keratinocyte proliferation 0.0636311023890666 0.27869639608081 1.42969283276451 0.5 24.1 24 1 decreased red blood cell distribution width 0.0636311023890666 0.27869639608081 1.42969283276451 0.5 24.1 24 1 embryonic lethality between implantation and placentation, incomplete penetrance 0.0636311023890666 0.27869639608081 1.42969283276451 0.5 24.1 24 1 abnormal prostate gland epithelium morphology 0.0891884869296095 0.347193053579661 1.42969283276451 0.5 24.1 24 1 bifid ureter 0.0891884869296095 0.347193053579661 1.42969283276451 0.5 24.1 24 1 abnormal reproductive system development 0.0891884869296095 0.347193053579661 1.42969283276451 0.5 24.1 24 1 abnormal embryonic erythrocyte morphology 0.0891884869296095 0.347193053579661 1.42969283276451 0.5 24.1 24 1 abnormal deltoid tuberosity morphology 0.0891884869296095 0.347193053579661 1.42969283276451 0.5 24.1 24 1 ascites 0.0891884869296095 0.347193053579661 1.42969283276451 0.5 24.1 24 1 abnormal developmental vascular remodeling 0.0891884869296095 0.347193053579661 1.42969283276451 0.5 24.1 24 1 abnormal hippocampus neuron morphology 0.0891884869296095 0.347193053579661 1.42969283276451 0.5 24.1 24 1 increased T-helper 17 cell number 0.0891884869296095 0.347193053579661 1.42969283276451 0.5 24.1 24 1 abnormal left subclavian artery morphology 0.0891884869296095 0.347193053579661 1.42969283276451 0.5 24.1 24 1 thin ventricle myocardium compact layer 0.0891884869296095 0.347193053579661 1.42969283276451 0.5 24.1 24 1 thick aortic valve 0.0891884869296095 0.347193053579661 1.42969283276451 0.5 24.1 24 1 fusion of atlas and odontoid process 0.0891884869296095 0.347193053579661 1.42969283276451 0.5 24.1 24 1 decreased trabecular bone connectivity density 0.0891884869296095 0.347193053579661 1.42969283276451 0.5 24.1 24 1 abnormal adaptive thermogenesis 0.0891884869296095 0.347193053579661 1.42969283276451 0.5 24.1 24 1 lethality during fetal growth through weaning, complete penetrance 0.0891884869296095 0.347193053579661 1.42969283276451 0.5 24.1 24 1 decreased circulating lactate level 0.0891884869296095 0.347193053579661 1.42969283276451 0.5 24.1 24 1 embryonic lethality during organogenesis, incomplete penetrance 4.07192517260435e-15 6.1387356768808e-13 1.4296928327645 0.5 24.1 24 1 increased cell proliferation 0.000126735158971325 0.00216669215079842 1.4296928327645 0.5 24.1 24 1 neurodegeneration 0.000126735158971325 0.00216669215079842 1.4296928327645 0.5 24.1 24 1 gastrointestinal hemorrhage 0.00397835775106328 0.0346019751949997 1.4296928327645 0.5 24.1 24 1 disorganized myocardium 0.00397835775106328 0.0346019751949997 1.4296928327645 0.5 24.1 24 1 liver hemorrhage 0.00397835775106328 0.0346019751949997 1.4296928327645 0.5 24.1 24 1 abnormal fat pad morphology 0.00397835775106328 0.0346019751949997 1.4296928327645 0.5 24.1 24 1 abnormal cellular respiration 0.00397835775106328 0.0346019751949997 1.4296928327645 0.5 24.1 24 1 decreased hemoglobin content 1.29692740347172e-09 7.68401042986596e-08 1.41955316728391 0.49645390070922 24.1 24 1 increased B cell number 3.47231921691331e-08 1.47647761573878e-06 1.41747323590327 0.495726495726496 24.1 24 1 hemorrhage 1.00335709973361e-14 1.42620044890706e-12 1.41144143489943 0.493617021276596 24.1 24 1 decreased percent body fat/body weight 1.50889746274961e-05 0.000340778824436607 1.41010799943896 0.493150684931507 24.1 24 1 microcephaly 2.63521077323211e-05 0.000573108449846626 1.40897264678241 0.492753623188406 24.1 24 1 abnormal rostral-caudal axis patterning 0.00018780440233801 0.00297641267930129 1.40369841762333 0.490909090909091 24.1 24 1 azoospermia 3.15034103911368e-10 2.20745727740712e-08 1.40271749629725 0.490566037735849 24.1 24 1 abnormal placenta development 0.000249112112753694 0.00372172000285174 1.40271749629725 0.490566037735849 24.1 24 1 abnormal gastrulation 0.000330632151948607 0.00464612081929155 1.4016596399652 0.490196078431373 24.1 24 1 increased circulating LDL cholesterol level 0.00043911428997172 0.00593639563209051 1.40051542801421 0.489795918367347 24.1 24 1 decreased bone trabecula number 0.00058360083964382 0.00722242332643782 1.39927383632271 0.48936170212766 24.1 24 1 abnormal double-strand DNA break repair 0.0010332840772055 0.0117903401011407 1.3964441622351 0.488372093023256 24.1 24 1 decreased inflammatory response 5.51648611103253e-06 0.00014074112001224 1.39565252722249 0.488095238095238 24.1 24 1 scaly skin 0.00137673156587014 0.0146664658248478 1.39482227586781 0.48780487804878 24.1 24 1 increased autoantibody level 0.00183617529425974 0.0182584442223827 1.3930340421808 0.487179487179487 24.1 24 1 decreased IgG level 2.23358094455279e-07 7.77067496444065e-06 1.39105248593303 0.486486486486487 24.1 24 1 abnormal branching of the mammary ductal tree 0.0024516533846493 0.0233211770337098 1.39105248593303 0.486486486486487 24.1 24 1 increased circulating serum albumin level 0.00327744814637577 0.0300269871520832 1.38884446611409 0.485714285714286 24.1 24 1 decreased circulating thyroxine level 0.00327744814637577 0.0300269871520832 1.38884446611409 0.485714285714286 24.1 24 1 abnormal vascular development 6.73418438992732e-05 0.00125477780299208 1.38636880752922 0.484848484848485 24.1 24 1 enlarged pericardium 0.0043873754861148 0.0371210766044577 1.38636880752922 0.484848484848485 24.1 24 1 abnormal ovarian folliculogenesis 0.0043873754861148 0.0371210766044577 1.38636880752922 0.484848484848485 24.1 24 1 abnormal epidermis stratum basale morphology 0.0043873754861148 0.0371210766044577 1.38636880752922 0.484848484848485 24.1 24 1 increased cardiomyocyte apoptosis 0.0043873754861148 0.0371210766044577 1.38636880752922 0.484848484848485 24.1 24 1 increased osteoblast cell number 0.0043873754861148 0.0371210766044577 1.38636880752922 0.484848484848485 24.1 24 1 myeloid hyperplasia 0.0043873754861148 0.0371210766044577 1.38636880752922 0.484848484848485 24.1 24 1 prenatal lethality 0.000117841344309323 0.00203562738867667 1.38357370912694 0.483870967741935 24.1 24 1 pericardial effusion 0.000117841344309323 0.00203562738867667 1.38357370912694 0.483870967741935 24.1 24 1 autoimmune response 0.00588216267000285 0.0460122001309185 1.38357370912694 0.483870967741935 24.1 24 1 abnormal capillary morphology 0.00588216267000285 0.0460122001309185 1.38357370912694 0.483870967741935 24.1 24 1 abnormal T cell proliferation 0.00588216267000285 0.0460122001309185 1.38357370912694 0.483870967741935 24.1 24 1 hypoglycemia 2.65280464436278e-06 7.25148522291475e-05 1.38357370912694 0.483870967741935 24.1 24 1 muscular ventricular septal defect 0.000155980428777543 0.00256954514294132 1.38203640500569 0.483333333333333 24.1 24 1 preweaning lethality, incomplete penetrance 2.31351501676071e-22 8.22124086313183e-20 1.37725911029148 0.481662591687042 24.1 24 1 abnormal neural tube morphology 9.58387313687462e-10 6.11279087896811e-08 1.37674124636582 0.481481481481481 24.1 24 1 axon degeneration 0.000362747855551609 0.00501297383713682 1.37674124636582 0.481481481481481 24.1 24 1 decreased circulating fructosamine level 0.0106303016549074 0.0771679102500896 1.37674124636582 0.481481481481481 24.1 24 1 testicular atrophy 0.000638455588457963 0.00784275691994658 1.37250511945393 0.48 24.1 24 1 mandible hypoplasia 0.0143366016963694 0.0983787495716386 1.37250511945393 0.48 24.1 24 1 abnormal thyroid gland morphology 0.0143366016963694 0.0983787495716386 1.37250511945393 0.48 24.1 24 1 decreased acute inflammation 0.0143366016963694 0.0983787495716386 1.37250511945393 0.48 24.1 24 1 small heart 0.000847812605877514 0.0100425421767634 1.37012229806598 0.479166666666667 24.1 24 1 increased lymphocyte cell number 7.34708210509239e-05 0.00134877245287213 1.36753227481822 0.478260869565217 24.1 24 1 conjunctivitis 0.019385202074863 0.118651717411836 1.36753227481822 0.478260869565217 24.1 24 1 abnormal B cell morphology 0.019385202074863 0.118651717411836 1.36753227481822 0.478260869565217 24.1 24 1 decreased effector memory CD8-positive, alpha-beta T cell number 0.019385202074863 0.118651717411836 1.36753227481822 0.478260869565217 24.1 24 1 trunk curl 0.0262910333264274 0.151167305613328 1.36161222168048 0.476190476190476 24.1 24 1 increased incidence of induced tumors 0.0262910333264274 0.151167305613328 1.36161222168048 0.476190476190476 24.1 24 1 liver degeneration 0.0262910333264274 0.151167305613328 1.36161222168048 0.476190476190476 24.1 24 1 increased insulin sensitivity 2.07420111348173e-08 9.29653201763209e-07 1.35970786892289 0.475524475524476 24.1 24 1 increased double-negative T cell number 0.000224177718816732 0.00341065489637077 1.3593800704974 0.475409836065574 24.1 24 1 abnormal pancreatic beta cell morphology 0.00265615964396287 0.0250747518571448 1.35820819112628 0.475 24.1 24 1 decreased hair follicle number 0.00354174360451118 0.0316347465316172 1.35444584156637 0.473684210526316 24.1 24 1 decreased neuron apoptosis 0.00354174360451118 0.0316347465316172 1.35444584156637 0.473684210526316 24.1 24 1 abnormal triglyceride level 0.0357849288290696 0.190203013808356 1.35444584156637 0.473684210526316 24.1 24 1 shiny skin 0.0357849288290696 0.190203013808356 1.35444584156637 0.473684210526316 24.1 24 1 altered susceptibility to infection 0.0357849288290696 0.190203013808356 1.35444584156637 0.473684210526316 24.1 24 1 increased susceptibility to ischemic brain injury 0.0357849288290696 0.190203013808356 1.35444584156637 0.473684210526316 24.1 24 1 increased left ventricle weight 0.0357849288290696 0.190203013808356 1.35444584156637 0.473684210526316 24.1 24 1 absent amnion 0.0357849288290696 0.190203013808356 1.35444584156637 0.473684210526316 24.1 24 1 decreased eye pigmentation 0.0357849288290696 0.190203013808356 1.35444584156637 0.473684210526316 24.1 24 1 increased liver cholesterol level 0.0357849288290696 0.190203013808356 1.35444584156637 0.473684210526316 24.1 24 1 increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 0.0357849288290696 0.190203013808356 1.35444584156637 0.473684210526316 24.1 24 1 shortened RR interval 0.0357849288290696 0.190203013808356 1.35444584156637 0.473684210526316 24.1 24 1 increased macrophage cell number 0.000392454223286932 0.00536390044190244 1.35444584156637 0.473684210526316 24.1 24 1 edema 1.73792093208171e-09 1.00536705082634e-07 1.34657115644099 0.47093023255814 24.1 24 1 abnormal adipose tissue morphology 0.0489173946231489 0.241912562872928 1.34559325436659 0.470588235294118 24.1 24 1 increased incidence of corneal inflammation 0.0489173946231489 0.241912562872928 1.34559325436659 0.470588235294118 24.1 24 1 hyperlipidemia 0.0489173946231489 0.241912562872928 1.34559325436659 0.470588235294118 24.1 24 1 increased hepatoma incidence 0.0489173946231489 0.241912562872928 1.34559325436659 0.470588235294118 24.1 24 1 increased trabecular bone mass 0.0489173946231489 0.241912562872928 1.34559325436659 0.470588235294118 24.1 24 1 abnormal cell cytoskeleton morphology 0.0489173946231489 0.241912562872928 1.34559325436659 0.470588235294118 24.1 24 1 abnormal respiratory system physiology 0.00120935342379418 0.0132371794245536 1.34216061851362 0.469387755102041 24.1 24 1 abnormal blood vessel morphology 4.13696566496228e-08 1.71511701526561e-06 1.3409532776274 0.468965517241379 24.1 24 1 decreased circulating LDL cholesterol level 0.000240529862544237 0.00362616989744721 1.34033703071672 0.46875 24.1 24 1 decreased eosinophil cell number 0.000240529862544237 0.00362616989744721 1.34033703071672 0.46875 24.1 24 1 scoliosis 0.00845498775547371 0.0638293840417021 1.34033703071672 0.46875 24.1 24 1 abnormal nervous system morphology 4.89166332278594e-05 0.000973441001234403 1.33920594461485 0.468354430379747 24.1 24 1 abnormal T-helper 1 physiology 0.00160443820331842 0.0166293334614773 1.33843584343911 0.468085106382979 24.1 24 1 increased respiratory quotient 0.00160443820331842 0.0166293334614773 1.33843584343911 0.468085106382979 24.1 24 1 increased bone mineral content 2.10267873627897e-06 5.9776152645645e-05 1.33787769671541 0.467889908256881 24.1 24 1 abnormal humoral immune response 3.62170552613771e-06 9.57150672940357e-05 1.33437997724687 0.466666666666667 24.1 24 1 abnormal ectoderm development 0.00212990045040495 0.0208587691747335 1.33437997724687 0.466666666666667 24.1 24 1 abnormal heart tube morphology 0.0113310883712249 0.0820555526154933 1.33437997724687 0.466666666666667 24.1 24 1 abnormal fontanelle morphology 0.0672232513159742 0.27869639608081 1.33437997724687 0.466666666666667 24.1 24 1 absent incisors 0.0672232513159742 0.27869639608081 1.33437997724687 0.466666666666667 24.1 24 1 abnormal prostate gland morphology 0.0672232513159742 0.27869639608081 1.33437997724687 0.466666666666667 24.1 24 1 hyperpigmentation 0.0672232513159742 0.27869639608081 1.33437997724687 0.466666666666667 24.1 24 1 absent egg cylinders 0.0672232513159742 0.27869639608081 1.33437997724687 0.466666666666667 24.1 24 1 joint inflammation 0.0672232513159742 0.27869639608081 1.33437997724687 0.466666666666667 24.1 24 1 abnormal placenta size 0.0672232513159742 0.27869639608081 1.33437997724687 0.466666666666667 24.1 24 1 abnormal trophectoderm morphology 0.0672232513159742 0.27869639608081 1.33437997724687 0.466666666666667 24.1 24 1 decreased brown adipose tissue mass 0.0672232513159742 0.27869639608081 1.33437997724687 0.466666666666667 24.1 24 1 abnormal seminiferous tubule morphology 5.7899310683803e-08 2.34186236302374e-06 1.3317686661368 0.465753424657534 24.1 24 1 abnormal enzyme/coenzyme activity 2.10150657995712e-08 9.3348171743631e-07 1.32952327123323 0.464968152866242 24.1 24 1 abnormal CD4-positive, alpha-beta T cell physiology 0.000147170371326869 0.002465227600509 1.32901023890785 0.464788732394366 24.1 24 1 abnormal coat/hair pigmentation 2.2406985585664e-06 6.2980086603773e-05 1.32757191613847 0.464285714285714 24.1 24 1 shortened head 0.0152106487187086 0.10157446627594 1.32757191613847 0.464285714285714 24.1 24 1 abnormal spleen germinal center morphology 0.0152106487187086 0.10157446627594 1.32757191613847 0.464285714285714 24.1 24 1 hypoxia 0.0152106487187086 0.10157446627594 1.32757191613847 0.464285714285714 24.1 24 1 abnormal renal tubule epithelium morphology 0.0152106487187086 0.10157446627594 1.32757191613847 0.464285714285714 24.1 24 1 arrested B cell differentiation 0.00376112025686115 0.0334135237105075 1.32508116207442 0.463414634146341 24.1 24 1 liver fibrosis 0.00376112025686115 0.0334135237105075 1.32508116207442 0.463414634146341 24.1 24 1 abnormal axon morphology 3.85119103730097e-06 0.000100312436704567 1.32378965996713 0.462962962962963 24.1 24 1 decreased white adipose tissue amount 0.000255516651996012 0.00379461296620943 1.32299933778208 0.462686567164179 24.1 24 1 acanthosis 0.00500365929901243 0.0414886750209781 1.31971646101339 0.461538461538462 24.1 24 1 decreased circulating glycerol level 0.0204566367110875 0.12422189875656 1.31971646101339 0.461538461538462 24.1 24 1 short premaxilla 0.092993567276128 0.356427578735544 1.31971646101339 0.461538461538462 24.1 24 1 absent teeth 0.092993567276128 0.356427578735544 1.31971646101339 0.461538461538462 24.1 24 1 tight skin 0.092993567276128 0.356427578735544 1.31971646101339 0.461538461538462 24.1 24 1 abnormal grip strength 0.092993567276128 0.356427578735544 1.31971646101339 0.461538461538462 24.1 24 1 abnormal bile duct development 0.092993567276128 0.356427578735544 1.31971646101339 0.461538461538462 24.1 24 1 abnormal telomere length 0.092993567276128 0.356427578735544 1.31971646101339 0.461538461538462 24.1 24 1 abnormal exocrine pancreas morphology 0.092993567276128 0.356427578735544 1.31971646101339 0.461538461538462 24.1 24 1 increased heart weight 2.35769215892898e-07 8.14549895185533e-06 1.3165516733371 0.460431654676259 24.1 24 1 gliosis 0.000443940467405548 0.00596919952795298 1.31622514762447 0.46031746031746 24.1 24 1 decreased susceptibility to hepatic steatosis 0.000443940467405548 0.00596919952795298 1.31622514762447 0.46031746031746 24.1 24 1 kyphosis 8.52689425695082e-08 3.26317684064079e-06 1.31531740614334 0.46 24.1 24 1 small seminiferous tubules 0.000155564278484049 0.00256954514294132 1.31377179227009 0.459459459459459 24.1 24 1 abnormal vocalization 0.00666228683734053 0.0514672003350452 1.31377179227009 0.459459459459459 24.1 24 1 decreased circulating chloride level 0.00666228683734053 0.0514672003350452 1.31377179227009 0.459459459459459 24.1 24 1 decreased width of hypertrophic chondrocyte zone 0.00666228683734053 0.0514672003350452 1.31377179227009 0.459459459459459 24.1 24 1 decreased circulating cholesterol level 4.06636939873657e-09 2.15214763390579e-07 1.31250489565266 0.459016393442623 24.1 24 1 hydrops fetalis 0.00020458853323205 0.00315117013259891 1.31055176336746 0.458333333333333 24.1 24 1 abnormal forebrain development 0.00020458853323205 0.00315117013259891 1.31055176336746 0.458333333333333 24.1 24 1 overriding aortic valve 0.00224465986269148 0.0215999667638107 1.31055176336746 0.458333333333333 24.1 24 1 abnormal body weight 0.0275703774680747 0.157674583216337 1.31055176336746 0.458333333333333 24.1 24 1 small lymph nodes 0.0275703774680747 0.157674583216337 1.31055176336746 0.458333333333333 24.1 24 1 abnormal truncus arteriosus septation 0.0275703774680747 0.157674583216337 1.31055176336746 0.458333333333333 24.1 24 1 abnormal intestinal goblet cell morphology 0.00887884068329252 0.0664244096231283 1.30714773281326 0.457142857142857 24.1 24 1 decreased triglyceride level 0.00887884068329252 0.0664244096231283 1.30714773281326 0.457142857142857 24.1 24 1 increased red blood cell distribution width 0.00887884068329252 0.0664244096231283 1.30714773281326 0.457142857142857 24.1 24 1 decreased brain weight 0.00101813605937602 0.0116441997595304 1.30428118076762 0.456140350877193 24.1 24 1 decreased circulating alanine transaminase level 0.000353934666859923 0.0049048049237552 1.30354346516764 0.455882352941176 24.1 24 1 abnormal heart morphology 1.02406785542086e-10 7.9605274698731e-09 1.29972075705864 0.454545454545455 24.1 24 1 abnormal head morphology 0.00134320593640764 0.0143400204584292 1.29972075705864 0.454545454545455 24.1 24 1 osteoporosis 0.00393861078982462 0.0346019751949997 1.29972075705864 0.454545454545455 24.1 24 1 lethality, incomplete penetrance 0.00393861078982462 0.0346019751949997 1.29972075705864 0.454545454545455 24.1 24 1 abnormal tail movements 0.0372484941570088 0.196721081137069 1.29972075705864 0.454545454545455 24.1 24 1 increased activated T cell number 0.0372484941570088 0.196721081137069 1.29972075705864 0.454545454545455 24.1 24 1 prolonged PR interval 0.0372484941570088 0.196721081137069 1.29972075705864 0.454545454545455 24.1 24 1 abnormal limb posture 0.0372484941570088 0.196721081137069 1.29972075705864 0.454545454545455 24.1 24 1 abnormal cerebral cortex pyramidal cell morphology 0.0372484941570088 0.196721081137069 1.29972075705864 0.454545454545455 24.1 24 1 abnormal sphenoid bone morphology 0.129749290254274 0.445789170590479 1.29972075705864 0.454545454545455 24.1 24 1 abnormal large intestine morphology 0.129749290254274 0.445789170590479 1.29972075705864 0.454545454545455 24.1 24 1 abnormal sebaceous gland morphology 0.129749290254274 0.445789170590479 1.29972075705864 0.454545454545455 24.1 24 1 abnormal food preference 0.129749290254274 0.445789170590479 1.29972075705864 0.454545454545455 24.1 24 1 retinal detachment 0.129749290254274 0.445789170590479 1.29972075705864 0.454545454545455 24.1 24 1 pharyngeal arch hypoplasia 0.129749290254274 0.445789170590479 1.29972075705864 0.454545454545455 24.1 24 1 abnormal spinal cord ventral horn morphology 0.129749290254274 0.445789170590479 1.29972075705864 0.454545454545455 24.1 24 1 decreased palatine bone horizontal plate size 0.129749290254274 0.445789170590479 1.29972075705864 0.454545454545455 24.1 24 1 decreased core body temperature 0.129749290254274 0.445789170590479 1.29972075705864 0.454545454545455 24.1 24 1 increased pancreatic beta cell proliferation 0.129749290254274 0.445789170590479 1.29972075705864 0.454545454545455 24.1 24 1 cardiovascular system phenotype 0.0118446646466061 0.0849270754989888 1.29972075705864 0.454545454545455 24.1 24 1 abnormal coat/ hair morphology 0.0017724393355239 0.0176711136156942 1.29481615042823 0.452830188679245 24.1 24 1 abnormal mesoderm development 0.0017724393355239 0.0176711136156942 1.29481615042823 0.452830188679245 24.1 24 1 increased circulating bilirubin level 0.0017724393355239 0.0176711136156942 1.29481615042823 0.452830188679245 24.1 24 1 skin edema 0.00522095019255438 0.0425807003409148 1.29353161059646 0.452380952380952 24.1 24 1 abnormal testis morphology 5.86175374081139e-06 0.000147283963942105 1.29293960528268 0.452173913043478 24.1 24 1 abnormal object recognition memory 0.0158184389487018 0.104510934621237 1.29133546185181 0.451612903225806 24.1 24 1 abnormal postnatal growth/weight/body size 0.0158184389487018 0.104510934621237 1.29133546185181 0.451612903225806 24.1 24 1 abnormal CD8-positive, alpha beta T cell morphology 0.0158184389487018 0.104510934621237 1.29133546185181 0.451612903225806 24.1 24 1 decreased susceptibility to bacterial infection induced morbidity/mortality 0.0158184389487018 0.104510934621237 1.29133546185181 0.451612903225806 24.1 24 1 distended abdomen 0.00233934307940265 0.0223994473656672 1.28952686876799 0.450980392156863 24.1 24 1 increased circulating free fatty acid level 0.000369113398841839 0.00508681207545194 1.28873720136519 0.450704225352113 24.1 24 1 anencephaly 0.0504660081610021 0.248336687043507 1.28672354948805 0.45 24.1 24 1 abnormal postnatal subventricular zone morphology 0.0504660081610021 0.248336687043507 1.28672354948805 0.45 24.1 24 1 increased erythrocyte cell number 0.00106017598275654 0.0120419532287986 1.28672354948805 0.45 24.1 24 1 decreased spleen weight 0.000484487434071128 0.00624436524482865 1.28465153088985 0.449275362318841 24.1 24 1 premature death 4.90228826950691e-34 4.06481402346614e-31 1.28190809163089 0.448315911730546 24.1 24 1 lordosis 0.0211507018611838 0.128010634743783 1.28179357420266 0.448275862068966 24.1 24 1 persistence of hyaloid vascular system 0.00918844088296426 0.0685344728526944 1.27919885036824 0.447368421052632 24.1 24 1 abnormal compact bone morphology 0.00918844088296426 0.0685344728526944 1.27919885036824 0.447368421052632 24.1 24 1 abnormal brain morphology 1.81837199920419e-07 6.49335650924539e-06 1.2787314777521 0.447204968944099 24.1 24 1 cardiac fibrosis 0.000134703635136263 0.00229503624932504 1.27831359164826 0.447058823529412 24.1 24 1 perinatal lethality, incomplete penetrance 7.32256769331824e-10 4.79339135187608e-08 1.27786704521429 0.446902654867257 24.1 24 1 abnormal craniofacial morphology 2.90348933166087e-05 0.000614674869149482 1.27700719043043 0.446601941747573 24.1 24 1 small testis 1.38618686585744e-11 1.25386902866196e-09 1.2742914378988 0.445652173913043 24.1 24 1 abnormal spermatogenesis 3.22137833854552e-08 1.38158252019517e-06 1.2742914378988 0.445652173913043 24.1 24 1 reduced male fertility 9.84719512740915e-10 6.20123996947602e-08 1.27223767497106 0.444933920704846 24.1 24 1 decreased heart weight 0.000230355402464393 0.00349395770506206 1.27083807356845 0.444444444444444 24.1 24 1 increased susceptibility to bacterial infection induced morbidity/mortality 0.000500733291329667 0.00643707525675734 1.27083807356845 0.444444444444444 24.1 24 1 increased circulating aspartate transaminase level 0.00109526895811238 0.0122724393392097 1.27083807356845 0.444444444444444 24.1 24 1 abnormal ovarian follicle morphology 0.00538557906136038 0.0433547828968736 1.27083807356845 0.444444444444444 24.1 24 1 underdeveloped hair follicles 0.0685995492982164 0.280429546227302 1.27083807356845 0.444444444444444 24.1 24 1 right pulmonary isomerism 0.0685995492982164 0.280429546227302 1.27083807356845 0.444444444444444 24.1 24 1 abnormal phrenic nerve morphology 0.0685995492982164 0.280429546227302 1.27083807356845 0.444444444444444 24.1 24 1 abnormal white adipose tissue morphology 0.0685995492982164 0.280429546227302 1.27083807356845 0.444444444444444 24.1 24 1 long tibia 0.0685995492982164 0.280429546227302 1.27083807356845 0.444444444444444 24.1 24 1 increased susceptibility to autoimmune disorder 0.0685995492982164 0.280429546227302 1.27083807356845 0.444444444444444 24.1 24 1 abnormal glycogen homeostasis 0.0685995492982164 0.280429546227302 1.27083807356845 0.444444444444444 24.1 24 1 abnormal pregnancy 0.0685995492982164 0.280429546227302 1.27083807356845 0.444444444444444 24.1 24 1 decreased tumor latency 0.0685995492982164 0.280429546227302 1.27083807356845 0.444444444444444 24.1 24 1 primary atelectasis 0.0685995492982164 0.280429546227302 1.27083807356845 0.444444444444444 24.1 24 1 abnormal type II pneumocyte morphology 0.0283177047560316 0.160822581234312 1.27083807356845 0.444444444444444 24.1 24 1 decreased bone ossification 0.0283177047560316 0.160822581234312 1.27083807356845 0.444444444444444 24.1 24 1 prenatal lethality, incomplete penetrance 1.97242761190355e-12 1.92408379788631e-10 1.26979297646847 0.444078947368421 24.1 24 1 decreased total body fat amount 2.15868557212748e-13 2.61938066374005e-11 1.26703316915657 0.44311377245509 24.1 24 1 increased osteoclast cell number 0.00143726105862217 0.0152135612056283 1.26562972080792 0.442622950819672 24.1 24 1 abnormal male meiosis 0.00143726105862217 0.0152135612056283 1.26562972080792 0.442622950819672 24.1 24 1 abnormal female meiosis 0.0031783370138925 0.0293907558440802 1.26472827513783 0.442307692307692 24.1 24 1 decreased oxygen consumption 0.00711431928681048 0.0542815156522339 1.26344948011747 0.441860465116279 24.1 24 1 decreased regulatory T cell number 0.0162076598189363 0.106516654688518 1.26149367596868 0.441176470588235 24.1 24 1 increased susceptibility to viral infection induced morbidity/mortality 0.0162076598189363 0.106516654688518 1.26149367596868 0.441176470588235 24.1 24 1 abnormal liver physiology 6.62676860359632e-05 0.0012394050301839 1.25812969283276 0.44 24.1 24 1 abnormal interventricular septum morphology 0.00418240431085539 0.0359990682465494 1.25812969283276 0.44 24.1 24 1 ruffled hair 0.0379683441458432 0.200098000133019 1.25812969283276 0.44 24.1 24 1 sparse hair 0.000309051168505257 0.00448259347904856 1.25534004828103 0.439024390243902 24.1 24 1 abnormal mammary gland development 0.0093999047656497 0.0692807795690478 1.25534004828103 0.439024390243902 24.1 24 1 increased bone trabecula number 0.0093999047656497 0.0692807795690478 1.25534004828103 0.439024390243902 24.1 24 1 increased circulating alkaline phosphatase level 5.66312448102814e-07 1.81768027697516e-05 1.25318754476889 0.438271604938272 24.1 24 1 abnormal lymph node morphology 0.00550355124491705 0.0435296779705283 1.25098122866894 0.4375 24.1 24 1 increased circulating follicle stimulating hormone level 0.021545567654546 0.12885294033303 1.25098122866894 0.4375 24.1 24 1 decreased susceptibility to parasitic infection 0.021545567654546 0.12885294033303 1.25098122866894 0.4375 24.1 24 1 bradykinesia 0.021545567654546 0.12885294033303 1.25098122866894 0.4375 24.1 24 1 increased fatty acid level 0.021545567654546 0.12885294033303 1.25098122866894 0.4375 24.1 24 1 pancreatic islet hyperplasia 0.021545567654546 0.12885294033303 1.25098122866894 0.4375 24.1 24 1 abnormal bone marrow cell number 0.0936135535509917 0.356605994575945 1.25098122866894 0.4375 24.1 24 1 abnormal olfaction 0.0936135535509917 0.356605994575945 1.25098122866894 0.4375 24.1 24 1 abnormal epicardium morphology 0.0936135535509917 0.356605994575945 1.25098122866894 0.4375 24.1 24 1 large intestinal inflammation 0.0936135535509917 0.356605994575945 1.25098122866894 0.4375 24.1 24 1 abnormal level of surface class II molecules 0.0936135535509917 0.356605994575945 1.25098122866894 0.4375 24.1 24 1 decreased creatinine clearance 0.0936135535509917 0.356605994575945 1.25098122866894 0.4375 24.1 24 1 increased heart left ventricle size 0.0936135535509917 0.356605994575945 1.25098122866894 0.4375 24.1 24 1 abnormal pulmonary alveolus wall morphology 0.0936135535509917 0.356605994575945 1.25098122866894 0.4375 24.1 24 1 decreased circulating calcium level 0.00324534629245688 0.0298439885489334 1.2477319267763 0.436363636363636 24.1 24 1 postnatal growth retardation 7.94629068667465e-22 2.63551974441376e-19 1.24747707956903 0.436274509803922 24.1 24 1 reduced female fertility 4.11341501378931e-09 2.15413049406335e-07 1.2448187595622 0.435344827586207 24.1 24 1 perimembraneous ventricular septal defect 0.00114620241173573 0.0127855538080387 1.24321115892566 0.434782608695652 24.1 24 1 abnormal circulating insulin level 0.0509894880663517 0.249432353126942 1.24321115892566 0.434782608695652 24.1 24 1 failure of embryo implantation 0.0509894880663517 0.249432353126942 1.24321115892566 0.434782608695652 24.1 24 1 abnormal postnatal growth 0.0509894880663517 0.249432353126942 1.24321115892566 0.434782608695652 24.1 24 1 abnormal neuron morphology 0.000114558280265875 0.00199275330182773 1.24195539007826 0.434343434343434 24.1 24 1 decreased compact bone thickness 0.00149614793477344 0.0157364396944987 1.23764454179614 0.432835820895522 24.1 24 1 maternal effect 0.00149614793477344 0.0157364396944987 1.23764454179614 0.432835820895522 24.1 24 1 increased brown adipose tissue amount 0.0164188154610073 0.107452009337441 1.23649109860714 0.432432432432432 24.1 24 1 increased trabecular bone volume 0.0164188154610073 0.107452009337441 1.23649109860714 0.432432432432432 24.1 24 1 teratozoospermia 0.000320940675119724 0.00464151121721113 1.23473471920571 0.431818181818182 24.1 24 1 embryonic lethality, incomplete penetrance 0.00952785774451977 0.0701144851584421 1.23473471920571 0.431818181818182 24.1 24 1 alopecia 0.000193139619912369 0.00304072661096213 1.23405065564936 0.431578947368421 24.1 24 1 impaired glucose tolerance 2.66145250000848e-09 1.45502485577387e-07 1.23368655730486 0.431451612903226 24.1 24 1 abnormal spermiogenesis 0.00329163865322965 0.0300475271556284 1.23249382134871 0.431034482758621 24.1 24 1 decreased body weight 1.23563167420023e-40 1.53681689478653e-37 1.2310602259507 0.430533117932149 24.1 24 1 rib bifurcation 0.038147996784024 0.20061975052909 1.22545099951243 0.428571428571429 24.1 24 1 straub tail 0.038147996784024 0.20061975052909 1.22545099951243 0.428571428571429 24.1 24 1 abnormal kidney blood vessel morphology 0.128348166513188 0.444970124322725 1.22545099951243 0.428571428571429 24.1 24 1 extended life span 0.128348166513188 0.444970124322725 1.22545099951243 0.428571428571429 24.1 24 1 abnormal spleen periarteriolar lymphoid sheath morphology 0.128348166513188 0.444970124322725 1.22545099951243 0.428571428571429 24.1 24 1 absent otoliths 0.128348166513188 0.444970124322725 1.22545099951243 0.428571428571429 24.1 24 1 decreased coping response 0.128348166513188 0.444970124322725 1.22545099951243 0.428571428571429 24.1 24 1 intestinal obstruction 0.128348166513188 0.444970124322725 1.22545099951243 0.428571428571429 24.1 24 1 absent olfactory bulb 0.128348166513188 0.444970124322725 1.22545099951243 0.428571428571429 24.1 24 1 split sternum 0.128348166513188 0.444970124322725 1.22545099951243 0.428571428571429 24.1 24 1 decreased CNS synapse formation 0.128348166513188 0.444970124322725 1.22545099951243 0.428571428571429 24.1 24 1 abnormal iris pigmentation 0.128348166513188 0.444970124322725 1.22545099951243 0.428571428571429 24.1 24 1 abnormal glucose homeostasis 4.89299258133701e-07 1.60148934816787e-05 1.22545099951243 0.428571428571429 24.1 24 1 polydactyly 0.000195659024843054 0.00305142209590656 1.22545099951243 0.428571428571429 24.1 24 1 abnormal craniofacial development 0.0073150325133712 0.0554760468811307 1.22545099951243 0.428571428571429 24.1 24 1 abnormal pancreas morphology 0.0125341206954712 0.0879727677020195 1.22545099951243 0.428571428571429 24.1 24 1 thick pulmonary interalveolar septum 0.0217042741706693 0.12885294033303 1.22545099951243 0.428571428571429 24.1 24 1 ovary cysts 0.0217042741706693 0.12885294033303 1.22545099951243 0.428571428571429 24.1 24 1 decreased glycogen level 0.0217042741706693 0.12885294033303 1.22545099951243 0.428571428571429 24.1 24 1 abnormal hippocampus pyramidal cell morphology 0.0217042741706693 0.12885294033303 1.22545099951243 0.428571428571429 24.1 24 1 abnormal anxiety-related response 0.0685972392869331 0.280429546227302 1.22545099951243 0.428571428571429 24.1 24 1 increased bone ossification 0.0685972392869331 0.280429546227302 1.22545099951243 0.428571428571429 24.1 24 1 increased blood urea nitrogen level 7.54305269177888e-06 0.000185775678918811 1.22263387077792 0.427586206896552 24.1 24 1 abnormal neurocranium morphology 0.00117443842949446 0.0129552797932039 1.22000455062571 0.426666666666667 24.1 24 1 abnormal maxilla morphology 0.00562199903899544 0.0441855374707778 1.21788648716976 0.425925925925926 24.1 24 1 impaired limb coordination 0.00562199903899544 0.0441855374707778 1.21788648716976 0.425925925925926 24.1 24 1 abnormal liver morphology 1.05546861726454e-06 3.2018026651775e-05 1.21404084123019 0.424581005586592 24.1 24 1 abnormal behavior 1.37807663751215e-09 8.06580149602697e-08 1.21369607385764 0.424460431654676 24.1 24 1 dextrocardia 0.0286936014498702 0.162216667287618 1.21307270658806 0.424242424242424 24.1 24 1 increased rib number 0.00118119191716231 0.0129832088478132 1.20974008926227 0.423076923076923 24.1 24 1 absent corpus luteum 0.00734223992492926 0.0555976310905983 1.20974008926227 0.423076923076923 24.1 24 1 abnormal nasal bone morphology 0.0508102629313306 0.249290984303126 1.20974008926227 0.423076923076923 24.1 24 1 abnormal Schwann cell morphology 0.0508102629313306 0.249290984303126 1.20974008926227 0.423076923076923 24.1 24 1 thick skin 0.0508102629313306 0.249290984303126 1.20974008926227 0.423076923076923 24.1 24 1 abnormal ovary morphology 0.00197962898774362 0.0194253534793382 1.20819112627986 0.422535211267606 24.1 24 1 thin ventricular wall 0.000548901515584421 0.00682696260008124 1.20729616989003 0.422222222222222 24.1 24 1 increased susceptibility to parasitic infection 0.000548901515584421 0.00682696260008124 1.20729616989003 0.422222222222222 24.1 24 1 altered response to myocardial infarction 0.012554907551444 0.0879727677020195 1.20729616989003 0.422222222222222 24.1 24 1 decreased osteoclast cell number 0.012554907551444 0.0879727677020195 1.20729616989003 0.422222222222222 24.1 24 1 abnormal frontal bone morphology 0.0216772696995839 0.12885294033303 1.20395185917011 0.421052631578947 24.1 24 1 incomplete somite formation 0.0216772696995839 0.12885294033303 1.20395185917011 0.421052631578947 24.1 24 1 decreased total retina thickness 0.0216772696995839 0.12885294033303 1.20395185917011 0.421052631578947 24.1 24 1 irregular coat pigmentation 0.092464727821232 0.356322247026049 1.20395185917011 0.421052631578947 24.1 24 1 oliguria 0.092464727821232 0.356322247026049 1.20395185917011 0.421052631578947 24.1 24 1 abnormal sternebra morphology 0.092464727821232 0.356322247026049 1.20395185917011 0.421052631578947 24.1 24 1 increased circulating VLDL cholesterol level 0.092464727821232 0.356322247026049 1.20395185917011 0.421052631578947 24.1 24 1 Leydig cell hypoplasia 0.092464727821232 0.356322247026049 1.20395185917011 0.421052631578947 24.1 24 1 thin interventricular septum 0.092464727821232 0.356322247026049 1.20395185917011 0.421052631578947 24.1 24 1 double outlet right ventricle 0.000199626023654347 0.0030938924226803 1.20254537335332 0.420560747663551 24.1 24 1 abnormal epidermal layer morphology 0.00256776422241599 0.0242863631302653 1.20177078696147 0.420289855072464 24.1 24 1 hyperkeratosis 0.00256776422241599 0.0242863631302653 1.20177078696147 0.420289855072464 24.1 24 1 enlarged liver 0.000331038787868671 0.00464612081929155 1.20094197952218 0.42 24.1 24 1 increased circulating chloride level 0.00958348741864133 0.0701144851584421 1.20094197952218 0.42 24.1 24 1 increased circulating creatinine level 0.000916068314314806 0.0106234029457253 1.19695213905866 0.418604651162791 24.1 24 1 kidney failure 0.016436377709707 0.107452009337441 1.19695213905866 0.418604651162791 24.1 24 1 decreased body size 2.87643791702715e-23 1.10079066440077e-20 1.196785479056 0.418546365914787 24.1 24 1 abnormal myocardium layer morphology 0.00152980042112104 0.0159679812793394 1.19442692357541 0.417721518987342 24.1 24 1 small ovary 0.000709386962972712 0.00858686165642152 1.19402917901211 0.417582417582418 24.1 24 1 abnormal skeleton morphology 0.000155376440831432 0.00256954514294132 1.19348271256863 0.417391304347826 24.1 24 1 reduced fertility 3.46010826437524e-05 0.000714275461214392 1.19312495396175 0.41726618705036 24.1 24 1 arrest of spermatogenesis 0.00118218966996169 0.0129832088478132 1.19141069397042 0.416666666666667 24.1 24 1 abnormal kidney physiology 0.012500784933646 0.0879652122275659 1.19141069397042 0.416666666666667 24.1 24 1 hypopigmentation 0.0677174242079782 0.280045041924099 1.19141069397042 0.416666666666667 24.1 24 1 mesocardia 0.176976567300851 0.545389361100994 1.19141069397042 0.416666666666667 24.1 24 1 small thyroid gland 0.176976567300851 0.545389361100994 1.19141069397042 0.416666666666667 24.1 24 1 decreased circulating ketone body level 0.176976567300851 0.545389361100994 1.19141069397042 0.416666666666667 24.1 24 1 absent ovary 0.176976567300851 0.545389361100994 1.19141069397042 0.416666666666667 24.1 24 1 decreased left ventricle systolic pressure 0.176976567300851 0.545389361100994 1.19141069397042 0.416666666666667 24.1 24 1 abnormal defecation 0.176976567300851 0.545389361100994 1.19141069397042 0.416666666666667 24.1 24 1 increased hepatocyte proliferation 0.176976567300851 0.545389361100994 1.19141069397042 0.416666666666667 24.1 24 1 pale placenta 0.176976567300851 0.545389361100994 1.19141069397042 0.416666666666667 24.1 24 1 abnormal fatty acid level 0.176976567300851 0.545389361100994 1.19141069397042 0.416666666666667 24.1 24 1 abnormal somatic nervous system physiology 0.176976567300851 0.545389361100994 1.19141069397042 0.416666666666667 24.1 24 1 decreased oligodendrocyte number 0.176976567300851 0.545389361100994 1.19141069397042 0.416666666666667 24.1 24 1 decreased prostaglandin level 0.176976567300851 0.545389361100994 1.19141069397042 0.416666666666667 24.1 24 1 persistent right dorsal aorta 0.176976567300851 0.545389361100994 1.19141069397042 0.416666666666667 24.1 24 1 epidermal hyperplasia 0.00561680491474714 0.0441855374707778 1.19141069397042 0.416666666666667 24.1 24 1 abnormal uterus morphology 0.0284932013953056 0.16126698173111 1.19141069397042 0.416666666666667 24.1 24 1 decreased circulating glucose level 7.92457017580326e-09 3.89725187474347e-07 1.188848520435 0.415770609318996 24.1 24 1 increased startle reflex 0.000914214773550035 0.0106234029457253 1.18873336656824 0.415730337078652 24.1 24 1 abnormal muscle physiology 0.000914214773550035 0.0106234029457253 1.18873336656824 0.415730337078652 24.1 24 1 lethality at weaning, incomplete penetrance 0.0215048447348898 0.12885294033303 1.18559893448764 0.414634146341463 24.1 24 1 focal hair loss 0.0501460873177932 0.247251520719545 1.18319406849476 0.413793103448276 24.1 24 1 increased susceptibility to induced arthritis 0.0501460873177932 0.247251520719545 1.18319406849476 0.413793103448276 24.1 24 1 increased double-positive T cell number 0.0501460873177932 0.247251520719545 1.18319406849476 0.413793103448276 24.1 24 1 atrial septal defect 0.0162938592399163 0.106941886172274 1.18105060097937 0.41304347826087 24.1 24 1 skin lesions 0.00557844265262543 0.0440519876139865 1.18006392545642 0.412698412698413 24.1 24 1 ventricular septal defect 7.24973688465457e-05 0.00133583114819098 1.17739409757077 0.411764705882353 24.1 24 1 kinked tail 0.000544644644898381 0.00680805806122976 1.17739409757077 0.411764705882353 24.1 24 1 abnormal gluconeogenesis 0.0123855165263544 0.0872775420943529 1.17739409757077 0.411764705882353 24.1 24 1 abnormal dendritic spine morphology 0.0123855165263544 0.0872775420943529 1.17739409757077 0.411764705882353 24.1 24 1 abnormal nervous system development 0.0374337605915238 0.197489882229937 1.17739409757077 0.411764705882353 24.1 24 1 abnormal glutamate-mediated receptor currents 0.124900864800482 0.442926142656467 1.17739409757077 0.411764705882353 24.1 24 1 abnormal tarsal bone morphology 0.124900864800482 0.442926142656467 1.17739409757077 0.411764705882353 24.1 24 1 enhanced behavioral response to cocaine 0.124900864800482 0.442926142656467 1.17739409757077 0.411764705882353 24.1 24 1 abnormal survival 0.124900864800482 0.442926142656467 1.17739409757077 0.411764705882353 24.1 24 1 delayed heart development 0.124900864800482 0.442926142656467 1.17739409757077 0.411764705882353 24.1 24 1 infertility 0.000421783249928675 0.00573325592457694 1.17582214283436 0.411214953271028 24.1 24 1 ataxia 1.74043519861268e-06 5.03410762389423e-05 1.17489609029162 0.410891089108911 24.1 24 1 abnormal heart looping 0.0281156237561359 0.160040306849858 1.17308129867857 0.41025641025641 24.1 24 1 abnormal circulating hormone level 0.0281156237561359 0.160040306849858 1.17308129867857 0.41025641025641 24.1 24 1 decreased trabecular bone volume 0.0281156237561359 0.160040306849858 1.17308129867857 0.41025641025641 24.1 24 1 abnormal eye morphology 7.20147124843083e-05 0.00133187061193098 1.17255383406585 0.410071942446043 24.1 24 1 short tail 0.0019472142034963 0.0191491535738479 1.17131460997574 0.409638554216867 24.1 24 1 abnormal lipid level 0.0019472142034963 0.0191491535738479 1.17131460997574 0.409638554216867 24.1 24 1 male infertility 9.5572373424289e-14 1.21916040457907e-11 1.17104065029618 0.409542743538767 24.1 24 1 enlarged heart 3.92699341079825e-07 1.33813645333707e-05 1.17086913028128 0.40948275862069 24.1 24 1 abnormal bone structure 3.62166593750605e-06 9.57150672940357e-05 1.17042211179685 0.409326424870466 24.1 24 1 increased sensitivity to xenobiotic induced morbidity/mortality 0.000418334098584097 0.00570195106974214 1.16974868135278 0.409090909090909 24.1 24 1 abnormal astrocyte morphology 0.0212191992240673 0.128269156913408 1.16974868135278 0.409090909090909 24.1 24 1 abnormal long bone epiphysis morphology 0.0903002166845731 0.34987817601694 1.16974868135278 0.409090909090909 24.1 24 1 abnormal enterocyte morphology 0.0903002166845731 0.34987817601694 1.16974868135278 0.409090909090909 24.1 24 1 intracerebral hemorrhage 0.0903002166845731 0.34987817601694 1.16974868135278 0.409090909090909 24.1 24 1 parakeratosis 0.0903002166845731 0.34987817601694 1.16974868135278 0.409090909090909 24.1 24 1 abnormal female reproductive system physiology 0.0903002166845731 0.34987817601694 1.16974868135278 0.409090909090909 24.1 24 1 increased bone volume 0.0903002166845731 0.34987817601694 1.16974868135278 0.409090909090909 24.1 24 1 cardiac hypertrophy 0.000894775732817764 0.010449552278799 1.16709619001184 0.408163265306122 24.1 24 1 decreased circulating creatinine level 0.0160771659131459 0.105938940950862 1.16709619001184 0.408163265306122 24.1 24 1 thin epidermis 0.0662738966768486 0.27869639608081 1.16493490077108 0.407407407407407 24.1 24 1 abnormal fetal cardiomyocyte proliferation 0.0662738966768486 0.27869639608081 1.16493490077108 0.407407407407407 24.1 24 1 abnormal bone trabecula morphology 0.0662738966768486 0.27869639608081 1.16493490077108 0.407407407407407 24.1 24 1 decreased circulating HDL cholesterol level 0.000192726377278424 0.00304072661096213 1.16162542662116 0.40625 24.1 24 1 abnormal calcium ion homeostasis 0.0367257372595999 0.19499524318731 1.15921040494419 0.405405405405405 24.1 24 1 hunched posture 0.00320832734030985 0.029613039922155 1.15823216831555 0.40506329113924 24.1 24 1 abnormal reproductive system morphology 0.0276049370816943 0.157674583216337 1.15737038842841 0.404761904761905 24.1 24 1 spina bifida 0.0276049370816943 0.157674583216337 1.15737038842841 0.404761904761905 24.1 24 1 decreased rib number 0.00189992877831957 0.0188289754425097 1.15660543774207 0.404494382022472 24.1 24 1 abnormal motor coordination/ balance 0.00113002619783881 0.0126334389533665 1.15530733960768 0.404040404040404 24.1 24 1 decreased kidney weight 0.0158019297079651 0.104510934621237 1.15475190338672 0.403846153846154 24.1 24 1 postnatal lethality 3.24328141217467e-05 0.000677834810322903 1.15408939512315 0.403614457831325 24.1 24 1 abnormal craniofacial bone morphology 0.0120160757613765 0.0849270754989888 1.15378719837136 0.403508771929825 24.1 24 1 increased total body fat amount 0.000187858006291579 0.00297641267930129 1.1522897458102 0.402985074626866 24.1 24 1 abnormal myocardial fiber morphology 0.00144223194372116 0.0152337662845282 1.14964990675909 0.402061855670103 24.1 24 1 decreased grip strength 2.61209916166318e-06 7.1796648228035e-05 1.14897688843175 0.401826484018265 24.1 24 1 decreased heart rate 0.0014177776812731 0.0150714614622514 1.1437542662116 0.4 24.1 24 1 decreased birth weight 0.00183868955887714 0.0182584442223827 1.1437542662116 0.4 24.1 24 1 kidney inflammation 0.0204062849094823 0.12410912888102 1.1437542662116 0.4 24.1 24 1 decreased circulating alkaline phosphatase level 0.0204062849094823 0.12410912888102 1.1437542662116 0.4 24.1 24 1 decreased respiratory quotient 0.0204062849094823 0.12410912888102 1.1437542662116 0.4 24.1 24 1 abnormal cochlear outer hair cell morphology 0.0875501442494012 0.345958671676546 1.1437542662116 0.4 24.1 24 1 hydroencephaly 0.000653447476974748 0.00800714580775707 1.1437542662116 0.4 24.1 24 1 decreased insulin secretion 0.00238705144131399 0.022750155020186 1.1437542662116 0.4 24.1 24 1 domed cranium 0.00687039443740464 0.052992577249749 1.1437542662116 0.4 24.1 24 1 decreased bone volume 0.0479200848720936 0.238641063301968 1.1437542662116 0.4 24.1 24 1 decreased bone mineralization 0.0479200848720936 0.238641063301968 1.1437542662116 0.4 24.1 24 1 abnormal cell proliferation 0.120463874261386 0.434595920558661 1.1437542662116 0.4 24.1 24 1 increased urine glucose level 0.120463874261386 0.434595920558661 1.1437542662116 0.4 24.1 24 1 abnormal dopamine level 0.120463874261386 0.434595920558661 1.1437542662116 0.4 24.1 24 1 abnormal male reproductive system physiology 0.120463874261386 0.434595920558661 1.1437542662116 0.4 24.1 24 1 abnormal neuron proliferation 0.120463874261386 0.434595920558661 1.1437542662116 0.4 24.1 24 1 abnormal circulating cytokine level 0.120463874261386 0.434595920558661 1.1437542662116 0.4 24.1 24 1 no suckling reflex 0.169098109977997 0.527768567842243 1.1437542662116 0.4 24.1 24 1 increased airway responsiveness 0.169098109977997 0.527768567842243 1.1437542662116 0.4 24.1 24 1 abnormal olfactory nerve morphology 0.169098109977997 0.527768567842243 1.1437542662116 0.4 24.1 24 1 absent chorion 0.169098109977997 0.527768567842243 1.1437542662116 0.4 24.1 24 1 abnormal secondary palate development 0.169098109977997 0.527768567842243 1.1437542662116 0.4 24.1 24 1 bicuspid aortic valve 0.169098109977997 0.527768567842243 1.1437542662116 0.4 24.1 24 1 abnormal microglial cell activation 0.169098109977997 0.527768567842243 1.1437542662116 0.4 24.1 24 1 decreased trabecular bone mass 0.169098109977997 0.527768567842243 1.1437542662116 0.4 24.1 24 1 microphthalmia 0.000107808537800484 0.0018819209668681 1.1400165071717 0.398692810457516 24.1 24 1 decreased litter size 2.03444973227528e-07 7.12773761835882e-06 1.13968396633185 0.398576512455516 24.1 24 1 abnormal lens morphology 0.000384474747043978 0.00526931643675975 1.13928647610921 0.3984375 24.1 24 1 abnormal cornea morphology 0.00515568355589721 0.0421174477677974 1.13642250809486 0.397435897435897 24.1 24 1 decreased susceptibility to injury 0.00879368534478367 0.0660854752119317 1.13534430837181 0.397058823529412 24.1 24 1 cataract 0.000629503241670738 0.00775192729532653 1.13430175161481 0.396694214876033 24.1 24 1 curly tail 0.026313746062541 0.151167305613328 1.1318401592719 0.395833333333333 24.1 24 1 female infertility 8.25378131399634e-07 2.5347260516748e-05 1.12870486797198 0.394736842105263 24.1 24 1 perinatal lethality, complete penetrance 1.01896157122822e-05 0.00024132398587844 1.12764505119454 0.394366197183099 24.1 24 1 atelectasis 0.0085872743394288 0.0646319059586358 1.12764505119454 0.394366197183099 24.1 24 1 weight loss 6.02356564334791e-05 0.0011394387481238 1.12741491955144 0.394285714285714 24.1 24 1 cachexia 0.00172915101976322 0.017414020897413 1.12725781044894 0.394230769230769 24.1 24 1 decreased body length 6.30906562925359e-07 1.98655705731244e-05 1.12705712363917 0.394160583941606 24.1 24 1 belly spot 0.0624423462909073 0.27869639608081 1.12642465611749 0.393939393939394 24.1 24 1 abnormal QRS complex 0.0624423462909073 0.27869639608081 1.12642465611749 0.393939393939394 24.1 24 1 improved glucose tolerance 2.71649776586806e-05 0.00058252484418938 1.1233300828864 0.392857142857143 24.1 24 1 abnormal seminal vesicle morphology 0.0193897178403664 0.118651717411836 1.1233300828864 0.392857142857143 24.1 24 1 prolonged QRS complex duration 0.0844730083722059 0.335933826260371 1.1233300828864 0.392857142857143 24.1 24 1 postnatal lethality, incomplete penetrance 1.55746053592884e-12 1.5496732332492e-10 1.12261092150171 0.392605633802817 24.1 24 1 abnormal visceral yolk sac morphology 0.0064133511117974 0.0497760090190204 1.12203741305569 0.392405063291139 24.1 24 1 small lung 0.0255809741889197 0.147639613213313 1.12132771197216 0.392156862745098 24.1 24 1 abnormal thrombosis 0.0255809741889197 0.147639613213313 1.12132771197216 0.392156862745098 24.1 24 1 increased circulating cholesterol level 7.41974139058313e-05 0.00135710343449085 1.12100915296308 0.392045454545455 24.1 24 1 increased sensitivity to induced morbidity/mortality 5.64014490086475e-05 0.00107098171304588 1.11889004303309 0.391304347826087 24.1 24 1 abnormal Wolffian duct morphology 0.115571399367716 0.419647189984231 1.11889004303309 0.391304347826087 24.1 24 1 abnormal palatal shelf fusion at midline 0.115571399367716 0.419647189984231 1.11889004303309 0.391304347826087 24.1 24 1 decreased bone mineral density 1.56412805098692e-06 4.60445979506504e-05 1.11795529780082 0.390977443609023 24.1 24 1 increased circulating HDL cholesterol level 0.0021358844117783 0.0208762769127643 1.11652202177799 0.39047619047619 24.1 24 1 cleft palate 0.000725547464757255 0.00876116174069743 1.11319594612198 0.389312977099237 24.1 24 1 abnormal neuromuscular synapse morphology 0.0106406404887561 0.0771679102500896 1.11198331437239 0.388888888888889 24.1 24 1 narrow eye opening 0.060282647084595 0.273637015735274 1.11198331437239 0.388888888888889 24.1 24 1 lowered ear position 0.160728974665559 0.52296173268963 1.11198331437239 0.388888888888889 24.1 24 1 abnormal mammary gland morphology 0.160728974665559 0.52296173268963 1.11198331437239 0.388888888888889 24.1 24 1 eye inflammation 0.160728974665559 0.52296173268963 1.11198331437239 0.388888888888889 24.1 24 1 decreased activity of thyroid 0.160728974665559 0.52296173268963 1.11198331437239 0.388888888888889 24.1 24 1 abnormal eye anterior chamber morphology 0.160728974665559 0.52296173268963 1.11198331437239 0.388888888888889 24.1 24 1 jerky movement 0.160728974665559 0.52296173268963 1.11198331437239 0.388888888888889 24.1 24 1 small thoracic cage 0.160728974665559 0.52296173268963 1.11198331437239 0.388888888888889 24.1 24 1 atrioventricular block 0.160728974665559 0.52296173268963 1.11198331437239 0.388888888888889 24.1 24 1 abnormal bone mineralization 0.0012106365101853 0.0132371794245536 1.11067046512284 0.388429752066116 24.1 24 1 rib fusion 0.0139263557630952 0.0959606924119092 1.10961234781723 0.388059701492537 24.1 24 1 abnormal epidermis stratum corneum morphology 0.0327969134904912 0.178322015972889 1.10874138051125 0.387755102040816 24.1 24 1 increased circulating insulin level 0.00024329179208771 0.00365672708651467 1.10801194539249 0.3875 24.1 24 1 abnormal retinal pigment epithelium morphology 0.0079162638600571 0.0598532107960244 1.10801194539249 0.3875 24.1 24 1 delayed bone ossification 0.0103297334808412 0.0751321989286331 1.10562912400455 0.386666666666667 24.1 24 1 abnormal suckling behavior 0.00590303514675787 0.0461029825041137 1.10476264349984 0.386363636363636 24.1 24 1 increased circulating triglyceride level 0.000519646910455897 0.00664704941955534 1.10431446392845 0.386206896551724 24.1 24 1 thick epidermis 0.0135031973819585 0.0931739347784237 1.10290589956119 0.385714285714286 24.1 24 1 abnormal renal glomerulus morphology 0.00254885482623777 0.0241995281689559 1.10178163258916 0.385321100917431 24.1 24 1 abnormal rib morphology 0.000863645453677453 0.0101389991773096 1.10139299709266 0.385185185185185 24.1 24 1 increased circulating alanine transaminase level 0.0100149319687965 0.0729491750289346 1.09976371751116 0.384615384615385 24.1 24 1 abnormal heart ventricle morphology 0.0100149319687965 0.0729491750289346 1.09976371751116 0.384615384615385 24.1 24 1 abnormal snout morphology 0.0316928769895164 0.172835611739767 1.09976371751116 0.384615384615385 24.1 24 1 eyelids open at birth 0.0316928769895164 0.172835611739767 1.09976371751116 0.384615384615385 24.1 24 1 decreased IgA level 0.0316928769895164 0.172835611739767 1.09976371751116 0.384615384615385 24.1 24 1 abnormal brain wave pattern 0.0316928769895164 0.172835611739767 1.09976371751116 0.384615384615385 24.1 24 1 increased vascular permeability 0.0580551624068901 0.263766605455962 1.09976371751116 0.384615384615385 24.1 24 1 ventricular hypoplasia 0.110512570073196 0.412179446985273 1.09976371751116 0.384615384615385 24.1 24 1 increased susceptibility to otitis media 0.110512570073196 0.412179446985273 1.09976371751116 0.384615384615385 24.1 24 1 uterus hypoplasia 0.229465942316303 0.6164888569159 1.09976371751116 0.384615384615385 24.1 24 1 excessive scratching 0.229465942316303 0.6164888569159 1.09976371751116 0.384615384615385 24.1 24 1 increased pituitary adenoma incidence 0.229465942316303 0.6164888569159 1.09976371751116 0.384615384615385 24.1 24 1 abnormal pulmonary alveolus epithelial cell morphology 0.229465942316303 0.6164888569159 1.09976371751116 0.384615384615385 24.1 24 1 abnormal lung interstitium morphology 0.229465942316303 0.6164888569159 1.09976371751116 0.384615384615385 24.1 24 1 abnormal otolith morphology 0.229465942316303 0.6164888569159 1.09976371751116 0.384615384615385 24.1 24 1 muscle fatigue 0.229465942316303 0.6164888569159 1.09976371751116 0.384615384615385 24.1 24 1 small otic vesicle 0.229465942316303 0.6164888569159 1.09976371751116 0.384615384615385 24.1 24 1 decreased endocochlear potential 0.229465942316303 0.6164888569159 1.09976371751116 0.384615384615385 24.1 24 1 abnormal vertebral arch development 0.229465942316303 0.6164888569159 1.09976371751116 0.384615384615385 24.1 24 1 increased circulating ammonia level 0.229465942316303 0.6164888569159 1.09976371751116 0.384615384615385 24.1 24 1 small pituitary gland 0.229465942316303 0.6164888569159 1.09976371751116 0.384615384615385 24.1 24 1 increased circulating thyroxine level 0.229465942316303 0.6164888569159 1.09976371751116 0.384615384615385 24.1 24 1 abnormal aorta tunica media morphology 0.229465942316303 0.6164888569159 1.09976371751116 0.384615384615385 24.1 24 1 decreased cardiac stroke volume 0.229465942316303 0.6164888569159 1.09976371751116 0.384615384615385 24.1 24 1 abnormal cardiovascular system physiology 0.00108213517210526 0.0121801413602345 1.09645615745849 0.383458646616541 24.1 24 1 abnormal eating behavior 0.0232242262184941 0.137058306541386 1.09609783845279 0.383333333333333 24.1 24 1 short maxilla 0.0779238517238591 0.316208125877813 1.09329451917286 0.382352941176471 24.1 24 1 decreased osteoblast cell number 0.0779238517238591 0.316208125877813 1.09329451917286 0.382352941176471 24.1 24 1 increased susceptibility to weight gain 0.0779238517238591 0.316208125877813 1.09329451917286 0.382352941176471 24.1 24 1 abnormal skin physiology 0.0779238517238591 0.316208125877813 1.09329451917286 0.382352941176471 24.1 24 1 increased food intake 0.00938264551462893 0.0692807795690478 1.08928977734438 0.380952380952381 24.1 24 1 abnormal hair follicle morphology 0.0224206159168757 0.132947037170985 1.08928977734438 0.380952380952381 24.1 24 1 abnormal scapula morphology 0.152381803476433 0.514663592868469 1.08928977734438 0.380952380952381 24.1 24 1 abnormal embryonic/fetal subventricular zone morphology 0.152381803476433 0.514663592868469 1.08928977734438 0.380952380952381 24.1 24 1 complete atrioventricular septal defect 0.152381803476433 0.514663592868469 1.08928977734438 0.380952380952381 24.1 24 1 vascular ring 0.152381803476433 0.514663592868469 1.08928977734438 0.380952380952381 24.1 24 1 neonatal lethality, incomplete penetrance 1.03106800398979e-05 0.00024132398587844 1.08876608033605 0.380769230769231 24.1 24 1 increased bone mineral density 0.00300746633216693 0.0279144496315867 1.08808481077653 0.380530973451327 24.1 24 1 abnormal locomotor behavior 0.00698017675912806 0.0537560052270311 1.08780976405995 0.380434782608696 24.1 24 1 decreased liver weight 0.0165197865216926 0.107855561608164 1.08737201365188 0.380281690140845 24.1 24 1 abnormal circulating protein level 0.0403911697175612 0.210182196690886 1.08656655290102 0.38 24.1 24 1 decreased oocyte number 0.0403911697175612 0.210182196690886 1.08656655290102 0.38 24.1 24 1 abnormal parietal bone morphology 0.105450571238792 0.397436812055294 1.08459456278687 0.379310344827586 24.1 24 1 insulin resistance 0.00163826296416424 0.0168842364153003 1.0831006308822 0.378787878787879 24.1 24 1 abnormal intestine morphology 0.0159397048328465 0.105172455627866 1.08192971128125 0.378378378378378 24.1 24 1 malocclusion 0.0746216356737225 0.304048024141498 1.08192971128125 0.378378378378378 24.1 24 1 abnormal hair follicle development 0.0746216356737225 0.304048024141498 1.08192971128125 0.378378378378378 24.1 24 1 abnormal lung morphology 0.00281618380279473 0.026335553418992 1.08128029368744 0.378151260504202 24.1 24 1 cardiomyopathy 0.0535624220987287 0.256460868231752 1.08021236253318 0.377777777777778 24.1 24 1 abnormal pancreatic islet morphology 0.0388301667266639 0.203776455132018 1.07901345869019 0.377358490566038 24.1 24 1 atrioventricular septal defect 0.0388301667266639 0.203776455132018 1.07901345869019 0.377358490566038 24.1 24 1 abnormal kidney morphology 0.000383933803986576 0.00526931643675975 1.07839687957094 0.377142857142857 24.1 24 1 abnormal sternum morphology 0.020827704756948 0.126209294964454 1.0774496710689 0.376811594202899 24.1 24 1 abnormal pulmonary alveolus morphology 0.00629411673758835 0.0490802990117587 1.07580846821884 0.376237623762376 24.1 24 1 increased body weight 8.5741364152625e-05 0.00153993966303 1.07226962457338 0.375 24.1 24 1 abnormal intestinal epithelium morphology 0.0513506566632297 0.250952374164605 1.07226962457338 0.375 24.1 24 1 abnormal female reproductive system morphology 0.0713669254085803 0.291263702959546 1.07226962457338 0.375 24.1 24 1 abnormal skin pigmentation 0.0713669254085803 0.291263702959546 1.07226962457338 0.375 24.1 24 1 abnormal crypts of Lieberkuhn morphology 0.100479442175217 0.380430155876489 1.07226962457338 0.375 24.1 24 1 polydipsia 0.100479442175217 0.380430155876489 1.07226962457338 0.375 24.1 24 1 abnormal lumbar vertebrae morphology 0.100479442175217 0.380430155876489 1.07226962457338 0.375 24.1 24 1 decreased body height 0.144283784463558 0.489639718762756 1.07226962457338 0.375 24.1 24 1 curly vibrissae 0.144283784463558 0.489639718762756 1.07226962457338 0.375 24.1 24 1 abnormal startle reflex 0.144283784463558 0.489639718762756 1.07226962457338 0.375 24.1 24 1 abnormal vasodilation 0.144283784463558 0.489639718762756 1.07226962457338 0.375 24.1 24 1 abnormal primitive streak formation 0.144283784463558 0.489639718762756 1.07226962457338 0.375 24.1 24 1 abnormal retinal ganglion layer morphology 0.144283784463558 0.489639718762756 1.07226962457338 0.375 24.1 24 1 abnormal inner cell mass apoptosis 0.144283784463558 0.489639718762756 1.07226962457338 0.375 24.1 24 1 abnormal hair follicle orientation 0.2143888438342 0.615810911128838 1.07226962457338 0.375 24.1 24 1 delayed hair appearance 0.2143888438342 0.615810911128838 1.07226962457338 0.375 24.1 24 1 mixed cellular infiltration to dermis 0.2143888438342 0.615810911128838 1.07226962457338 0.375 24.1 24 1 poor circulation 0.2143888438342 0.615810911128838 1.07226962457338 0.375 24.1 24 1 abnormal extraembryonic endoderm formation 0.2143888438342 0.615810911128838 1.07226962457338 0.375 24.1 24 1 increased cochlear outer hair cell number 0.2143888438342 0.615810911128838 1.07226962457338 0.375 24.1 24 1 increased thymus weight 0.2143888438342 0.615810911128838 1.07226962457338 0.375 24.1 24 1 abnormal amnion morphology 0.2143888438342 0.615810911128838 1.07226962457338 0.375 24.1 24 1 decreased circulating prolactin level 0.2143888438342 0.615810911128838 1.07226962457338 0.375 24.1 24 1 decreased circulating triiodothyronine level 0.2143888438342 0.615810911128838 1.07226962457338 0.375 24.1 24 1 kidney degeneration 0.2143888438342 0.615810911128838 1.07226962457338 0.375 24.1 24 1 abnormal digit morphology 0.0200472741414544 0.12237446485121 1.07226962457338 0.375 24.1 24 1 abnormal nervous system physiology 0.00437384795180502 0.0371210766044577 1.06916159667606 0.373913043478261 24.1 24 1 limb grasping 0.000429986667229736 0.00582883833642489 1.06834189701084 0.373626373626374 24.1 24 1 abnormal gait 7.36235907508757e-06 0.000182227544271446 1.06417265869203 0.372168284789644 24.1 24 1 abnormal homeostasis 0.068188115264865 0.280429546227302 1.06395745694103 0.372093023255814 24.1 24 1 delayed endochondral bone ossification 0.068188115264865 0.280429546227302 1.06395745694103 0.372093023255814 24.1 24 1 impaired adaptive thermogenesis 0.0956533503180846 0.364097488777713 1.06205753291078 0.371428571428571 24.1 24 1 respiratory failure 0.00159360208913154 0.0165861305301871 1.06043441900414 0.370860927152318 24.1 24 1 abnormal small intestine morphology 0.0470752165555853 0.234903914106356 1.05903172797371 0.37037037037037 24.1 24 1 rectal prolapse 0.13653531912987 0.466847568846119 1.05903172797371 0.37037037037037 24.1 24 1 cryptorchism 0.13653531912987 0.466847568846119 1.05903172797371 0.37037037037037 24.1 24 1 abnormal skin appearance 0.13653531912987 0.466847568846119 1.05903172797371 0.37037037037037 24.1 24 1 thick interventricular septum 0.13653531912987 0.466847568846119 1.05903172797371 0.37037037037037 24.1 24 1 abnormal fertility/fecundity 0.0241393076583483 0.140624186885577 1.05758099957922 0.36986301369863 24.1 24 1 abnormal sleep pattern 0.0651033531264717 0.27869639608081 1.05672948508681 0.369565217391304 24.1 24 1 neonatal lethality, complete penetrance 1.49070914442182e-07 5.41334160109385e-06 1.05345787677385 0.368421052631579 24.1 24 1 abnormal reproductive system physiology 0.0910026159305055 0.352325302921607 1.05345787677385 0.368421052631579 24.1 24 1 kyphoscoliosis 0.20054978532475 0.583129855050049 1.05345787677385 0.368421052631579 24.1 24 1 short vibrissae 0.20054978532475 0.583129855050049 1.05345787677385 0.368421052631579 24.1 24 1 decreased germ cell number 0.20054978532475 0.583129855050049 1.05345787677385 0.368421052631579 24.1 24 1 abnormal nasal septum morphology 0.20054978532475 0.583129855050049 1.05345787677385 0.368421052631579 24.1 24 1 abnormal neural crest cell migration 0.20054978532475 0.583129855050049 1.05345787677385 0.368421052631579 24.1 24 1 abnormal response to novelty 0.20054978532475 0.583129855050049 1.05345787677385 0.368421052631579 24.1 24 1 abnormal digestive system development 0.20054978532475 0.583129855050049 1.05345787677385 0.368421052631579 24.1 24 1 decreased liver regeneration 0.20054978532475 0.583129855050049 1.05345787677385 0.368421052631579 24.1 24 1 decreased susceptibility to weight gain 0.20054978532475 0.583129855050049 1.05345787677385 0.368421052631579 24.1 24 1 no abnormal phenotype detected 9.11710438014034e-25 4.53575942911982e-22 1.05146285568156 0.367723342939481 24.1 24 1 abnormal long bone hypertrophic chondrocyte zone 0.0621237978603039 0.27869639608081 1.05038657101066 0.36734693877551 24.1 24 1 abnormal hair cycle 0.129176010637178 0.445789170590479 1.04844141069397 0.366666666666667 24.1 24 1 arrested T cell differentiation 0.129176010637178 0.445789170590479 1.04844141069397 0.366666666666667 24.1 24 1 abnormal lactation 0.129176010637178 0.445789170590479 1.04844141069397 0.366666666666667 24.1 24 1 abnormal skeletal muscle fiber morphology 0.0301455325727879 0.169270908069548 1.04709897610922 0.366197183098592 24.1 24 1 thick ventricular wall 0.0865429130410202 0.34279537609799 1.04611670690086 0.365853658536585 24.1 24 1 increased tumor growth/size 0.0865429130410202 0.34279537609799 1.04611670690086 0.365853658536585 24.1 24 1 abnormal cholesterol homeostasis 0.0865429130410202 0.34279537609799 1.04611670690086 0.365853658536585 24.1 24 1 palatal shelves fail to meet at midline 0.0865429130410202 0.34279537609799 1.04611670690086 0.365853658536585 24.1 24 1 abnormal cranium morphology 0.00414314778866562 0.0357229813667443 1.04559625082777 0.365671641791045 24.1 24 1 postnatal lethality, complete penetrance 2.43591394164167e-06 6.80824261779061e-05 1.04449061875542 0.365284974093264 24.1 24 1 hyperglycemia 0.0195152451889282 0.119273150878277 1.03977660564691 0.363636363636364 24.1 24 1 abnormal joint morphology 0.0565023037698248 0.256946034053819 1.03977660564691 0.363636363636364 24.1 24 1 abnormal circadian rhythm 0.0822807587661006 0.328002223446595 1.03977660564691 0.363636363636364 24.1 24 1 omphalocele 0.0822807587661006 0.328002223446595 1.03977660564691 0.363636363636364 24.1 24 1 abnormal amino acid level 0.0822807587661006 0.328002223446595 1.03977660564691 0.363636363636364 24.1 24 1 abnormal basisphenoid bone morphology 0.187856995928925 0.552031042378264 1.03977660564691 0.363636363636364 24.1 24 1 testis hypoplasia 0.187856995928925 0.552031042378264 1.03977660564691 0.363636363636364 24.1 24 1 decreased airway responsiveness 0.187856995928925 0.552031042378264 1.03977660564691 0.363636363636364 24.1 24 1 aphakia 0.187856995928925 0.552031042378264 1.03977660564691 0.363636363636364 24.1 24 1 decreased cardiac output 0.187856995928925 0.552031042378264 1.03977660564691 0.363636363636364 24.1 24 1 abnormal circulating lipid level 0.187856995928925 0.552031042378264 1.03977660564691 0.363636363636364 24.1 24 1 abnormal blood-brain barrier function 0.187856995928925 0.552031042378264 1.03977660564691 0.363636363636364 24.1 24 1 cleft upper lip 0.187856995928925 0.552031042378264 1.03977660564691 0.363636363636364 24.1 24 1 decreased circulating estradiol level 0.187856995928925 0.552031042378264 1.03977660564691 0.363636363636364 24.1 24 1 abnormal occipital bone morphology 0.187856995928925 0.552031042378264 1.03977660564691 0.363636363636364 24.1 24 1 increased circulating creatine kinase level 0.187856995928925 0.552031042378264 1.03977660564691 0.363636363636364 24.1 24 1 decreased systemic arterial blood pressure 0.12221492553768 0.440274623135379 1.03977660564691 0.363636363636364 24.1 24 1 decreased sensitivity to xenobiotic induced morbidity/mortality 0.12221492553768 0.440274623135379 1.03977660564691 0.363636363636364 24.1 24 1 glomerulosclerosis 0.0538639979318645 0.256460868231752 1.03529480993292 0.362068965517241 24.1 24 1 abnormal enzyme/coenzyme level 0.0538639979318645 0.256460868231752 1.03529480993292 0.362068965517241 24.1 24 1 hepatic necrosis 0.0782168912916218 0.316931567789877 1.03424587902113 0.361702127659574 24.1 24 1 abnormal retinal blood vessel morphology 0.115645486928318 0.419647189984231 1.03255593477436 0.361111111111111 24.1 24 1 hypoactivity 7.61579311239558e-06 0.000186643205587034 1.03150252125184 0.360742705570292 24.1 24 1 abnormal feces composition 0.176196457084021 0.545389361100994 1.02937883959044 0.36 24.1 24 1 increased urine protein level 0.0326788639655632 0.177874560425248 1.02644613634375 0.358974358974359 24.1 24 1 abnormal response to injury 0.10945318990373 0.411898350810179 1.02644613634375 0.358974358974359 24.1 24 1 impaired coordination 2.6380268344699e-05 0.000573108449846626 1.02475093215491 0.358381502890173 24.1 24 1 abnormal retina morphology 0.00103637561788188 0.0117985553751998 1.02120916626036 0.357142857142857 24.1 24 1 abnormal muscle morphology 0.103619745623389 0.390832626593148 1.02120916626036 0.357142857142857 24.1 24 1 myoclonus 0.16545882510635 0.52296173268963 1.02120916626036 0.357142857142857 24.1 24 1 abnormal hormone level 0.16545882510635 0.52296173268963 1.02120916626036 0.357142857142857 24.1 24 1 increased triglyceride level 0.16545882510635 0.52296173268963 1.02120916626036 0.357142857142857 24.1 24 1 midline facial cleft 0.285642484429144 0.637251730957396 1.02120916626036 0.357142857142857 24.1 24 1 abnormal blood flow velocity 0.285642484429144 0.637251730957396 1.02120916626036 0.357142857142857 24.1 24 1 abnormal fluid regulation 0.285642484429144 0.637251730957396 1.02120916626036 0.357142857142857 24.1 24 1 abnormal ventral body wall morphology 0.285642484429144 0.637251730957396 1.02120916626036 0.357142857142857 24.1 24 1 abnormal pancreas development 0.285642484429144 0.637251730957396 1.02120916626036 0.357142857142857 24.1 24 1 premature hair loss 0.285642484429144 0.637251730957396 1.02120916626036 0.357142857142857 24.1 24 1 increased circulating growth hormone level 0.285642484429144 0.637251730957396 1.02120916626036 0.357142857142857 24.1 24 1 abnormal glucose tolerance 0.285642484429144 0.637251730957396 1.02120916626036 0.357142857142857 24.1 24 1 increased pulmonary respiratory rate 0.285642484429144 0.637251730957396 1.02120916626036 0.357142857142857 24.1 24 1 short limbs 0.0284139119201273 0.161001380185231 1.0188615589816 0.35632183908046 24.1 24 1 abnormal retinal pigmentation 0.0284139119201273 0.161001380185231 1.0188615589816 0.35632183908046 24.1 24 1 abnormal metabolism 0.0981253583067195 0.372367397083089 1.01667045885476 0.355555555555556 24.1 24 1 abnormal axial skeleton morphology 0.0403367240502675 0.210182196690886 1.01583438117478 0.355263157894737 24.1 24 1 small cranium 0.155546359835729 0.52296173268963 1.01462072002642 0.354838709677419 24.1 24 1 retinal degeneration 0.0246934418898424 0.142848690002286 1.01269908987486 0.354166666666667 24.1 24 1 abnormal trabecular bone morphology 0.0146249252636091 0.10021901265352 1.00919494077494 0.352941176470588 24.1 24 1 impaired balance 0.0224854853721144 0.133172963959844 1.00919494077494 0.352941176470588 24.1 24 1 abnormal cervical vertebrae morphology 0.0880740436694533 0.347193053579661 1.00919494077494 0.352941176470588 24.1 24 1 distended urinary bladder 0.263200468761683 0.6164888569159 1.00919494077494 0.352941176470588 24.1 24 1 abnormal cranial suture morphology 0.263200468761683 0.6164888569159 1.00919494077494 0.352941176470588 24.1 24 1 absence seizures 0.263200468761683 0.6164888569159 1.00919494077494 0.352941176470588 24.1 24 1 abnormal testis development 0.263200468761683 0.6164888569159 1.00919494077494 0.352941176470588 24.1 24 1 coloboma 0.263200468761683 0.6164888569159 1.00919494077494 0.352941176470588 24.1 24 1 decreased body fat mass 0.263200468761683 0.6164888569159 1.00919494077494 0.352941176470588 24.1 24 1 abnormal lung development 0.0348967558370525 0.18748527029086 1.00919494077494 0.352941176470588 24.1 24 1 small kidney 0.0332535376862176 0.179255402675617 1.00728358672045 0.352272727272727 24.1 24 1 short snout 0.0204747652221868 0.12422189875656 1.00608014157502 0.351851851851852 24.1 24 1 abnormal neuronal precursor proliferation 0.0834787559406376 0.332245448643738 1.00608014157502 0.351851851851852 24.1 24 1 abnormal osteoblast physiology 0.0834787559406376 0.332245448643738 1.00608014157502 0.351851851851852 24.1 24 1 increased thermal nociceptive threshold 0.03168898941228 0.172835611739767 1.0054982560102 0.351648351648352 24.1 24 1 decreased startle reflex 0.0177921246163888 0.109954669724021 1.00200694262128 0.35042735042735 24.1 24 1 perinatal lethality 0.129961178478041 0.446209015133372 1.00078498293515 0.35 24.1 24 1 brain inflammation 0.243672968205024 0.6164888569159 1.00078498293515 0.35 24.1 24 1 kidney atrophy 0.243672968205024 0.6164888569159 1.00078498293515 0.35 24.1 24 1 decreased circulating VLDL cholesterol level 0.243672968205024 0.6164888569159 1.00078498293515 0.35 24.1 24 1 nuclear cataracts 0.243672968205024 0.6164888569159 1.00078498293515 0.35 24.1 24 1 decreased muscle cell glucose uptake 0.243672968205024 0.6164888569159 1.00078498293515 0.35 24.1 24 1 abnormal male reproductive system morphology 0.122600976172599 0.441026649644743 0.997460115882213 0.348837209302326 24.1 24 1 abnormal blood circulation 0.122600976172599 0.441026649644743 0.997460115882213 0.348837209302326 24.1 24 1 abnormal tail morphology 0.0675648841347623 0.279879515878803 0.996452580411625 0.348484848484849 24.1 24 1 abnormal nasal cavity morphology 0.226409314094903 0.6164888569159 0.994568927140525 0.347826086956522 24.1 24 1 abnormal cardiovascular development 0.226409314094903 0.6164888569159 0.994568927140525 0.347826086956522 24.1 24 1 abnormal sacral vertebrae morphology 0.226409314094903 0.6164888569159 0.994568927140525 0.347826086956522 24.1 24 1 decreased epididymis weight 0.226409314094903 0.6164888569159 0.994568927140525 0.347826086956522 24.1 24 1 abnormal corneal stroma morphology 0.226409314094903 0.6164888569159 0.994568927140525 0.347826086956522 24.1 24 1 abnormal chondrocyte physiology 0.226409314094903 0.6164888569159 0.994568927140525 0.347826086956522 24.1 24 1 decreased bone mineral content 0.00323965160755417 0.0298439885489334 0.989787345760042 0.346153846153846 24.1 24 1 abnormal skin condition 0.10333076813415 0.390038369853868 0.989787345760042 0.346153846153846 24.1 24 1 increased susceptibility to injury 0.10333076813415 0.390038369853868 0.989787345760042 0.346153846153846 24.1 24 1 abnormal xiphoid process morphology 0.210970279619164 0.610219268084501 0.989787345760042 0.346153846153846 24.1 24 1 abnormal nerve conduction 0.210970279619164 0.610219268084501 0.989787345760042 0.346153846153846 24.1 24 1 abnormal skeleton development 0.0521639808617233 0.254676942872496 0.98842961277546 0.345679012345679 24.1 24 1 increased circulating calcium level 0.0977163279196776 0.371381765775704 0.987787775364567 0.345454545454545 24.1 24 1 abnormal learning/memory/conditioning 0.0977163279196776 0.371381765775704 0.987787775364567 0.345454545454545 24.1 24 1 decreased retinal photoreceptor cell number 0.197042116615591 0.576637958919156 0.985995057078969 0.344827586206897 24.1 24 1 stomach inflammation 0.197042116615591 0.576637958919156 0.985995057078969 0.344827586206897 24.1 24 1 short sternum 0.197042116615591 0.576637958919156 0.985995057078969 0.344827586206897 24.1 24 1 enlarged epididymis 0.197042116615591 0.576637958919156 0.985995057078969 0.344827586206897 24.1 24 1 abnormal long bone morphology 0.0875132803720894 0.345958671676546 0.984378671739495 0.344262295081967 24.1 24 1 abnormal lymphatic vessel morphology 0.18439093575314 0.545389361100994 0.982913822525597 0.34375 24.1 24 1 increased dopamine level 0.18439093575314 0.545389361100994 0.982913822525597 0.34375 24.1 24 1 abnormal heart atrium morphology 0.18439093575314 0.545389361100994 0.982913822525597 0.34375 24.1 24 1 abnormal depression-related behavior 0.18439093575314 0.545389361100994 0.982913822525597 0.34375 24.1 24 1 impaired branching involved in ureteric bud morphogenesis 0.162236084046797 0.52296173268963 0.978210885575714 0.342105263157895 24.1 24 1 abnormal gametogenesis 0.143456261038029 0.489167168378475 0.974790567793981 0.340909090909091 24.1 24 1 renal interstitial fibrosis 0.143456261038029 0.489167168378475 0.974790567793981 0.340909090909091 24.1 24 1 increased circulating glucose level 0.0193619377008474 0.118651717411836 0.973407886137535 0.340425531914894 24.1 24 1 increased hemoglobin content 0.107117382839907 0.403413307818726 0.969283276450512 0.338983050847458 24.1 24 1 kidney cysts 0.0812052798695371 0.324494993856183 0.966008670786828 0.337837837837838 24.1 24 1 obese 0.0769326630966345 0.313207855078361 0.965506848100705 0.337662337662338 24.1 24 1 decreased cardiac muscle contractility 0.0479898864460385 0.238749685069041 0.962293252822263 0.336538461538462 24.1 24 1 hyperactivity 0.00072760395026709 0.00876472070842317 0.955697634839885 0.334231805929919 24.1 24 1 abnormal response to novel object 0.146981034184976 0.498453064124238 0.953128555176337 0.333333333333333 24.1 24 1 cyanosis 0.0130558809411064 0.0907164911759838 0.953128555176337 0.333333333333333 24.1 24 1 abnormal digestive system morphology 0.267472078910575 0.621423197545553 0.953128555176337 0.333333333333333 24.1 24 1 abnormal adrenal gland morphology 0.267472078910575 0.621423197545553 0.953128555176337 0.333333333333333 24.1 24 1 increased stereotypic behavior 0.267472078910575 0.621423197545553 0.953128555176337 0.333333333333333 24.1 24 1 abnormal cardiac muscle contractility 0.267472078910575 0.621423197545553 0.953128555176337 0.333333333333333 24.1 24 1 abnormal impulse conducting system conduction 0.267472078910575 0.621423197545553 0.953128555176337 0.333333333333333 24.1 24 1 prolonged QT interval 0.267472078910575 0.621423197545553 0.953128555176337 0.333333333333333 24.1 24 1 abnormal salivary gland morphology 0.289318550569319 0.643720835904455 0.953128555176337 0.333333333333333 24.1 24 1 abnormal associative learning 0.289318550569319 0.643720835904455 0.953128555176337 0.333333333333333 24.1 24 1 dry skin 0.289318550569319 0.643720835904455 0.953128555176337 0.333333333333333 24.1 24 1 decreased cochlear outer hair cell number 0.289318550569319 0.643720835904455 0.953128555176337 0.333333333333333 24.1 24 1 increased keratinocyte proliferation 0.289318550569319 0.643720835904455 0.953128555176337 0.333333333333333 24.1 24 1 abnormal motor capabilities/coordination/movement 0.0345530902181138 0.185839593335261 0.953128555176337 0.333333333333333 24.1 24 1 absent gastric milk in neonates 0.0879444798211428 0.347193053579661 0.953128555176337 0.333333333333333 24.1 24 1 abnormal skin morphology 0.109832589969697 0.412179446985273 0.953128555176337 0.333333333333333 24.1 24 1 abnormal circulating amino acid level 0.130526057736492 0.447839404992445 0.953128555176337 0.333333333333333 24.1 24 1 heart right ventricle hypertrophy 0.201431977430636 0.58432891412094 0.953128555176337 0.333333333333333 24.1 24 1 abnormal epidermis stratum granulosum morphology 0.201431977430636 0.58432891412094 0.953128555176337 0.333333333333333 24.1 24 1 impaired wound healing 0.201431977430636 0.58432891412094 0.953128555176337 0.333333333333333 24.1 24 1 renal hypoplasia 0.201431977430636 0.58432891412094 0.953128555176337 0.333333333333333 24.1 24 1 delayed eyelid opening 0.230975169604798 0.6164888569159 0.953128555176337 0.333333333333333 24.1 24 1 abnormal skeleton physiology 0.215478940860871 0.6164888569159 0.953128555176337 0.333333333333333 24.1 24 1 abnormal microglial cell physiology 0.230975169604798 0.6164888569159 0.953128555176337 0.333333333333333 24.1 24 1 abnormal heart shape 0.314436215809745 0.688824382938566 0.953128555176337 0.333333333333333 24.1 24 1 cortical renal glomerulopathies 0.314436215809745 0.688824382938566 0.953128555176337 0.333333333333333 24.1 24 1 delayed kidney development 0.314436215809745 0.688824382938566 0.953128555176337 0.333333333333333 24.1 24 1 absent spleen 0.314436215809745 0.688824382938566 0.953128555176337 0.333333333333333 24.1 24 1 abnormal retinal rod cell morphology 0.314436215809745 0.688824382938566 0.953128555176337 0.333333333333333 24.1 24 1 decreased heart rate variability 0.314436215809745 0.688824382938566 0.953128555176337 0.333333333333333 24.1 24 1 decreased pulmonary respiratory rate 0.314436215809745 0.688824382938566 0.953128555176337 0.333333333333333 24.1 24 1 abnormal sperm axoneme morphology 0.314436215809745 0.688824382938566 0.953128555176337 0.333333333333333 24.1 24 1 increased adipocyte glucose uptake 0.314436215809745 0.688824382938566 0.953128555176337 0.333333333333333 24.1 24 1 decreased chondrocyte number 0.343914671654718 0.734770736478506 0.953128555176337 0.333333333333333 24.1 24 1 decreased salivation 0.343914671654718 0.734770736478506 0.953128555176337 0.333333333333333 24.1 24 1 abnormal epidermis stratum spinosum morphology 0.343914671654718 0.734770736478506 0.953128555176337 0.333333333333333 24.1 24 1 abnormal apical ectodermal ridge morphology 0.343914671654718 0.734770736478506 0.953128555176337 0.333333333333333 24.1 24 1 dilated ureter 0.343914671654718 0.734770736478506 0.953128555176337 0.333333333333333 24.1 24 1 abnormal glial cell morphology 0.343914671654718 0.734770736478506 0.953128555176337 0.333333333333333 24.1 24 1 abnormal pericyte morphology 0.343914671654718 0.734770736478506 0.953128555176337 0.333333333333333 24.1 24 1 abnormal coronary vessel morphology 0.343914671654718 0.734770736478506 0.953128555176337 0.333333333333333 24.1 24 1 abnormal trigeminal ganglion morphology 0.248187759863812 0.6164888569159 0.953128555176337 0.333333333333333 24.1 24 1 wrinkled skin 0.248187759863812 0.6164888569159 0.953128555176337 0.333333333333333 24.1 24 1 abnormal palate morphology 0.248187759863812 0.6164888569159 0.953128555176337 0.333333333333333 24.1 24 1 increased or absent threshold for auditory brainstem response 0.00328335296698156 0.0300269871520832 0.949830532494066 0.332179930795848 24.1 24 1 increased liver weight 0.0848660641100916 0.337227371363982 0.942297548867515 0.329545454545455 24.1 24 1 impaired fertilization 0.118210970486126 0.42833181221302 0.939512432959532 0.328571428571429 24.1 24 1 abnormal action potential 0.118210970486126 0.42833181221302 0.939512432959532 0.328571428571429 24.1 24 1 abnormal tooth morphology 0.132569036701767 0.454535463536384 0.938235921501707 0.328125 24.1 24 1 cochlear ganglion degeneration 0.149074538995058 0.505208332084751 0.936695304225021 0.327586206896552 24.1 24 1 abnormal contextual conditioning behavior 0.158269568525989 0.52296173268963 0.935798945082222 0.327272727272727 24.1 24 1 abnormal hair growth 0.168182591981092 0.527558887204245 0.934799159884484 0.326923076923077 24.1 24 1 abnormal forelimb morphology 0.190501366275054 0.559141178299937 0.932408369194242 0.326086956521739 24.1 24 1 abnormal intestinal mucosa morphology 0.203115778648173 0.588293069751824 0.930962774823399 0.325581395348837 24.1 24 1 abnormal posture 0.112974345672496 0.412179446985273 0.929300341296928 0.325 24.1 24 1 increased white adipose tissue amount 0.231943291545553 0.6164888569159 0.927368323955355 0.324324324324324 24.1 24 1 abnormal breathing pattern 0.231943291545553 0.6164888569159 0.927368323955355 0.324324324324324 24.1 24 1 abnormal endoderm development 0.248529276759661 0.6164888569159 0.925095362377033 0.323529411764706 24.1 24 1 abnormal vision 0.248529276759661 0.6164888569159 0.925095362377033 0.323529411764706 24.1 24 1 lethargy 0.101987149056485 0.385844917533091 0.922382472751294 0.32258064516129 24.1 24 1 abnormal podocyte morphology 0.266893650447211 0.621423197545553 0.922382472751294 0.32258064516129 24.1 24 1 preaxial polydactyly 0.266893650447211 0.621423197545553 0.922382472751294 0.32258064516129 24.1 24 1 short mandible 0.179523816107568 0.545389361100994 0.919088249634325 0.321428571428571 24.1 24 1 abnormal eye development 0.179523816107568 0.545389361100994 0.919088249634325 0.321428571428571 24.1 24 1 enhanced coordination 0.287375150012083 0.640829839224613 0.919088249634325 0.321428571428571 24.1 24 1 abnormal vertebrae morphology 0.0873933235400595 0.345888452356242 0.918151360490967 0.321100917431193 24.1 24 1 increased exploration in new environment 0.127008599452698 0.44341598756293 0.917827497577213 0.320987654320988 24.1 24 1 enlarged kidney 0.19087518858209 0.559908056129656 0.917161439886664 0.320754716981132 24.1 24 1 abnormal limb morphology 0.142124926359049 0.48529273070437 0.915003412969283 0.32 24.1 24 1 abnormal hindlimb morphology 0.203153265092188 0.588293069751824 0.915003412969283 0.32 24.1 24 1 abnormal axon extension 0.203153265092188 0.588293069751824 0.915003412969283 0.32 24.1 24 1 abnormal vertebrae development 0.310425312711306 0.686601530917855 0.915003412969283 0.32 24.1 24 1 abnormal stomach mucosa morphology 0.310425312711306 0.686601530917855 0.915003412969283 0.32 24.1 24 1 abnormal heart left ventricle morphology 0.15046649684455 0.50957850360901 0.913414865377323 0.319444444444444 24.1 24 1 increased body size 0.33666727606817 0.734613902824186 0.909804529941049 0.318181818181818 24.1 24 1 abnormal response/metabolism to endogenous compounds 0.142051364729569 0.48529273070437 0.906634479314076 0.317073170731707 24.1 24 1 abnormal incisor morphology 0.19025554298542 0.558749307173828 0.90547212741752 0.316666666666667 24.1 24 1 seizures 0.102514590753849 0.387545660334649 0.902963894377582 0.315789473684211 24.1 24 1 increased grooming behavior 0.264115848852672 0.618050963331159 0.902963894377582 0.315789473684211 24.1 24 1 hyporesponsive to tactile stimuli 0.264115848852672 0.618050963331159 0.902963894377582 0.315789473684211 24.1 24 1 thin dermal layer 0.366999183725896 0.780265358562536 0.902963894377582 0.315789473684211 24.1 24 1 abnormal neurotransmitter level 0.366999183725896 0.780265358562536 0.902963894377582 0.315789473684211 24.1 24 1 increased kidney weight 0.228831999221199 0.6164888569159 0.897062169577729 0.313725490196078 24.1 24 1 oligodactyly 0.243874697167634 0.6164888569159 0.893558020477816 0.3125 24.1 24 1 abnormal cardiovascular system morphology 0.243874697167634 0.6164888569159 0.893558020477816 0.3125 24.1 24 1 abnormal hair shaft morphology 0.243874697167634 0.6164888569159 0.893558020477816 0.3125 24.1 24 1 abnormal vertebral body morphology 0.304394884399062 0.675151382026452 0.893558020477816 0.3125 24.1 24 1 kidney cortex cysts 0.304394884399062 0.675151382026452 0.893558020477816 0.3125 24.1 24 1 abnormal diaphragm morphology 0.304394884399062 0.675151382026452 0.893558020477816 0.3125 24.1 24 1 absent mandible 0.402790047936771 0.816648759302798 0.893558020477816 0.3125 24.1 24 1 vasculature congestion 0.402790047936771 0.816648759302798 0.893558020477816 0.3125 24.1 24 1 white spotting 0.402790047936771 0.816648759302798 0.893558020477816 0.3125 24.1 24 1 abnormal molar crown morphology 0.402790047936771 0.816648759302798 0.893558020477816 0.3125 24.1 24 1 bowed tibia 0.402790047936771 0.816648759302798 0.893558020477816 0.3125 24.1 24 1 bowed radius 0.402790047936771 0.816648759302798 0.893558020477816 0.3125 24.1 24 1 small epididymis 0.402790047936771 0.816648759302798 0.893558020477816 0.3125 24.1 24 1 sepsis 0.402790047936771 0.816648759302798 0.893558020477816 0.3125 24.1 24 1 abnormal fertilization 0.402790047936771 0.816648759302798 0.893558020477816 0.3125 24.1 24 1 loose skin 0.402790047936771 0.816648759302798 0.893558020477816 0.3125 24.1 24 1 abnormal thoracic cage shape 0.402790047936771 0.816648759302798 0.893558020477816 0.3125 24.1 24 1 respiratory distress 0.0676591763546955 0.28003694040317 0.89252500542524 0.312138728323699 24.1 24 1 abnormal maternal nurturing 0.21275141919676 0.615013544743684 0.89062832205002 0.311475409836066 24.1 24 1 irregular heartbeat 0.260237288236427 0.6164888569159 0.889586651497914 0.311111111111111 24.1 24 1 aphagia 0.328025015040504 0.717014257393017 0.887395551371072 0.310344827586207 24.1 24 1 corneal opacity 0.198248160606261 0.579485663346738 0.886006825938567 0.309859154929577 24.1 24 1 abnormal cartilage morphology 0.278096469794139 0.622931083847744 0.885047944092313 0.30952380952381 24.1 24 1 abnormal optic nerve morphology 0.278096469794139 0.622931083847744 0.885047944092313 0.30952380952381 24.1 24 1 decreased anxiety-related response 0.123861508418553 0.442926142656467 0.883387441382946 0.308943089430894 24.1 24 1 abnormal locomotor activation 0.173094549261826 0.539903061177168 0.879810974008926 0.307692307692308 24.1 24 1 small lens 0.297666212290157 0.661406612837666 0.879810974008926 0.307692307692308 24.1 24 1 abnormal iris morphology 0.297666212290157 0.661406612837666 0.879810974008926 0.307692307692308 24.1 24 1 abnormal stomach morphology 0.354627549641147 0.755253450113315 0.879810974008926 0.307692307692308 24.1 24 1 small seminal vesicle 0.354627549641147 0.755253450113315 0.879810974008926 0.307692307692308 24.1 24 1 no spontaneous movement 0.354627549641147 0.755253450113315 0.879810974008926 0.307692307692308 24.1 24 1 abnormal ocular fundus morphology 0.354627549641147 0.755253450113315 0.879810974008926 0.307692307692308 24.1 24 1 abnormal spatial learning 0.0979624627753759 0.372033017028622 0.877112167340187 0.306748466257669 24.1 24 1 absent kidney 0.272542325823843 0.621423197545553 0.875322142508881 0.306122448979592 24.1 24 1 abnormal systemic arterial blood pressure 0.319209333932098 0.698665392130307 0.873701175578309 0.305555555555556 24.1 24 1 reduced long term depression 0.319209333932098 0.698665392130307 0.873701175578309 0.305555555555556 24.1 24 1 delayed wound healing 0.290746754094528 0.646609343594223 0.87024781124796 0.304347826086957 24.1 24 1 abnormal blood vessel physiology 0.384905134431474 0.789454813116523 0.87024781124796 0.304347826086957 24.1 24 1 abnormal cochlear ganglion morphology 0.384905134431474 0.789454813116523 0.87024781124796 0.304347826086957 24.1 24 1 abnormal ulna morphology 0.384905134431474 0.789454813116523 0.87024781124796 0.304347826086957 24.1 24 1 decreased food intake 0.215612562348182 0.6164888569159 0.868674126236661 0.30379746835443 24.1 24 1 abnormal tooth development 0.343053990285232 0.734770736478506 0.866480504705761 0.303030303030303 24.1 24 1 absent vibrissae 0.343053990285232 0.734770736478506 0.866480504705761 0.303030303030303 24.1 24 1 abnormal locomotor coordination 0.343053990285232 0.734770736478506 0.866480504705761 0.303030303030303 24.1 24 1 single kidney 0.343053990285232 0.734770736478506 0.866480504705761 0.303030303030303 24.1 24 1 abnormal urine homeostasis 0.197348140659417 0.577194003398353 0.863772753128555 0.302083333333333 24.1 24 1 increased body length 0.302280494708839 0.671359580882355 0.857815699658703 0.3 24.1 24 1 decreased circulating phosphate level 0.332291320342786 0.72538364138015 0.857815699658703 0.3 24.1 24 1 impaired ovarian folliculogenesis 0.332291320342786 0.72538364138015 0.857815699658703 0.3 24.1 24 1 waved hair 0.419853276091984 0.816648759302798 0.857815699658703 0.3 24.1 24 1 abnormal circulating enzyme level 0.419853276091984 0.816648759302798 0.857815699658703 0.3 24.1 24 1 abnormal hair texture 0.419853276091984 0.816648759302798 0.857815699658703 0.3 24.1 24 1 abnormal hyoid bone morphology 0.419853276091984 0.816648759302798 0.857815699658703 0.3 24.1 24 1 abnormal lens epithelium morphology 0.419853276091984 0.816648759302798 0.857815699658703 0.3 24.1 24 1 abnormal response to tactile stimuli 0.419853276091984 0.816648759302798 0.857815699658703 0.3 24.1 24 1 enhanced paired-pulse facilitation 0.369617805941521 0.785161650110618 0.857815699658703 0.3 24.1 24 1 abnormal synaptic transmission 0.369617805941521 0.785161650110618 0.857815699658703 0.3 24.1 24 1 cleft secondary palate 0.226786862515132 0.6164888569159 0.851731900370343 0.297872340425532 24.1 24 1 pulmonary hypoplasia 0.322258252707753 0.704718596580691 0.851731900370343 0.297872340425532 24.1 24 1 hydronephrosis 0.244358938421932 0.6164888569159 0.851007638550301 0.297619047619048 24.1 24 1 abnormal long bone metaphysis morphology 0.356129582634098 0.758127802141479 0.850087630292408 0.297297297297297 24.1 24 1 abnormal mandible morphology 0.31286620566695 0.68811201290587 0.847225382378966 0.296296296296296 24.1 24 1 abnormal trigeminal nerve morphology 0.399444303231604 0.815108863239224 0.847225382378966 0.296296296296296 24.1 24 1 hypertension 0.343981838264432 0.734770736478506 0.844818492088117 0.295454545454545 24.1 24 1 lung hemorrhage 0.382439287587553 0.789454813116523 0.840995783979121 0.294117647058824 24.1 24 1 overexpanded pulmonary alveoli 0.382439287587553 0.789454813116523 0.840995783979121 0.294117647058824 24.1 24 1 thin skin 0.382439287587553 0.789454813116523 0.840995783979121 0.294117647058824 24.1 24 1 abnormal touch/ nociception 0.460952372593058 0.832996023846881 0.840995783979121 0.294117647058824 24.1 24 1 decreased vasoconstriction 0.460952372593058 0.832996023846881 0.840995783979121 0.294117647058824 24.1 24 1 aminoaciduria 0.460952372593058 0.832996023846881 0.840995783979121 0.294117647058824 24.1 24 1 decreased growth hormone level 0.460952372593058 0.832996023846881 0.840995783979121 0.294117647058824 24.1 24 1 abnormal foregut morphology 0.433259921998902 0.816648759302798 0.833987485779295 0.291666666666667 24.1 24 1 abnormal nursing 0.433259921998902 0.816648759302798 0.833987485779295 0.291666666666667 24.1 24 1 abnormal sensory capabilities/reflexes/nociception 0.433259921998902 0.816648759302798 0.833987485779295 0.291666666666667 24.1 24 1 increased circulating total protein level 0.433259921998902 0.816648759302798 0.833987485779295 0.291666666666667 24.1 24 1 abnormal eyelid morphology 0.411641324098283 0.816648759302798 0.830144225476164 0.290322580645161 24.1 24 1 decreased neuronal precursor cell number 0.411641324098283 0.816648759302798 0.830144225476164 0.290322580645161 24.1 24 1 abnormal coat appearance 0.321597413351618 0.703582731497054 0.828807439283771 0.289855072463768 24.1 24 1 decreased threshold for auditory brainstem response 0.393616659359863 0.803546524544653 0.82771690317945 0.289473684210526 24.1 24 1 albuminuria 0.378003061713309 0.789454813116523 0.826044747819492 0.288888888888889 24.1 24 1 decreased body temperature 0.36413947091459 0.7748476765612 0.824822788133368 0.288461538461538 24.1 24 1 abnormal thoracic vertebrae morphology 0.351616331350127 0.750124892138458 0.823890784982935 0.288135593220339 24.1 24 1 increased fluid intake 0.387330437831504 0.791038147870169 0.816967333008289 0.285714285714286 24.1 24 1 abnormal circulating cholesterol level 0.444271964519412 0.816648759302798 0.816967333008289 0.285714285714286 24.1 24 1 abnormal ovulation 0.444271964519412 0.816648759302798 0.816967333008289 0.285714285714286 24.1 24 1 corneal vascularization 0.444271964519412 0.816648759302798 0.816967333008289 0.285714285714286 24.1 24 1 small ears 0.472067166301051 0.85184408862812 0.816967333008289 0.285714285714286 24.1 24 1 abnormal bile salt homeostasis 0.472067166301051 0.85184408862812 0.816967333008289 0.285714285714286 24.1 24 1 abnormal long bone epiphyseal plate morphology 0.381076241369706 0.789454813116523 0.810159271899886 0.283333333333333 24.1 24 1 abnormal auditory brainstem response waveform shape 0.453607322241457 0.820915397654147 0.804202218430034 0.28125 24.1 24 1 abnormal blood homeostasis 0.332197275360886 0.72538364138015 0.802634572780073 0.280701754385965 24.1 24 1 abnormal facial morphology 0.403632346738345 0.816648759302798 0.802634572780073 0.280701754385965 24.1 24 1 increased anxiety-related response 0.310831999995917 0.686601530917855 0.802273675939794 0.280575539568345 24.1 24 1 abnormal nest building behavior 0.481028936721857 0.859218069687234 0.800627986348123 0.28 24.1 24 1 decreased placenta weight 0.481028936721857 0.859218069687234 0.800627986348123 0.28 24.1 24 1 increased liver glycogen level 0.481028936721857 0.859218069687234 0.800627986348123 0.28 24.1 24 1 abnormal organ of Corti morphology 0.439480009348999 0.816648759302798 0.79796809270577 0.27906976744186 24.1 24 1 abnormal stomach glandular epithelium morphology 0.51730474058664 0.89547358539267 0.794273795980281 0.277777777777778 24.1 24 1 abnormal radius morphology 0.51730474058664 0.89547358539267 0.794273795980281 0.277777777777778 24.1 24 1 thick dermal layer 0.51730474058664 0.89547358539267 0.794273795980281 0.277777777777778 24.1 24 1 increased circulating renin level 0.51730474058664 0.89547358539267 0.794273795980281 0.277777777777778 24.1 24 1 absent ureter 0.51730474058664 0.89547358539267 0.794273795980281 0.277777777777778 24.1 24 1 abnormal macrophage chemotaxis 0.51730474058664 0.89547358539267 0.794273795980281 0.277777777777778 24.1 24 1 decreased fluid intake 0.51730474058664 0.89547358539267 0.794273795980281 0.277777777777778 24.1 24 1 abnormal chondrocyte morphology 0.427738827786231 0.816648759302798 0.79427379598028 0.277777777777778 24.1 24 1 polyphagia 0.427738827786231 0.816648759302798 0.79427379598028 0.277777777777778 24.1 24 1 abnormal tibia morphology 0.446833834457033 0.816648759302798 0.790893907486747 0.276595744680851 24.1 24 1 abnormal innervation 0.446833834457033 0.816648759302798 0.790893907486747 0.276595744680851 24.1 24 1 abnormal circulating glucose level 0.488556516701852 0.860073839558286 0.788796045663175 0.275862068965517 24.1 24 1 abnormal outer ear morphology 0.488556516701852 0.860073839558286 0.788796045663175 0.275862068965517 24.1 24 1 decreased bone strength 0.488556516701852 0.860073839558286 0.788796045663175 0.275862068965517 24.1 24 1 increased susceptibility to weight loss 0.468870847941058 0.846690551182128 0.786331058020478 0.275 24.1 24 1 abnormal nervous system electrophysiology 0.419811843887858 0.816648759302798 0.782927027466277 0.273809523809524 24.1 24 1 polyuria 0.435182680749023 0.816648759302798 0.779832454235185 0.272727272727273 24.1 24 1 short femur 0.425062857757255 0.816648759302798 0.779832454235185 0.272727272727273 24.1 24 1 intestinal ulcer 0.522842125138381 0.904429614938611 0.779832454235185 0.272727272727273 24.1 24 1 diarrhea 0.495064821725042 0.870914953352929 0.779832454235185 0.272727272727273 24.1 24 1 abnormal colon morphology 0.465322719863122 0.840588428220418 0.77542662116041 0.271186440677966 24.1 24 1 abnormal phalanx morphology 0.481116691620798 0.859218069687234 0.774416951080774 0.270833333333333 24.1 24 1 increased insulin secretion 0.500813474320433 0.875286625703688 0.772806936629462 0.27027027027027 24.1 24 1 short humerus 0.505975006682549 0.882308327460807 0.767152251727296 0.268292682926829 24.1 24 1 enhanced long term potentiation 0.491378070681112 0.864735020034854 0.765906874695271 0.267857142857143 24.1 24 1 abnormal autopod morphology 0.510669555066585 0.88645535117106 0.762502844141069 0.266666666666667 24.1 24 1 increased circulating corticosterone level 0.510669555066585 0.88645535117106 0.762502844141069 0.266666666666667 24.1 24 1 abnormal response to new environment 0.531806956978337 0.918659587141398 0.762502844141069 0.266666666666667 24.1 24 1 abnormal estrous cycle 0.531806956978337 0.918659587141398 0.762502844141069 0.266666666666667 24.1 24 1 emphysema 0.531806956978337 0.918659587141398 0.762502844141069 0.266666666666667 24.1 24 1 impaired synaptic plasticity 0.535610014014538 0.924587029744041 0.756896205581209 0.264705882352941 24.1 24 1 increased width of hypertrophic chondrocyte zone 0.535610014014538 0.924587029744041 0.756896205581209 0.264705882352941 24.1 24 1 cochlear outer hair cell degeneration 0.508065609997734 0.88533324334106 0.754560106181267 0.263888888888889 24.1 24 1 impaired righting response 0.50326360194159 0.877887945182122 0.752469911981319 0.263157894736842 24.1 24 1 abnormal nail morphology 0.570985296608335 0.936775313452746 0.752469911981319 0.263157894736842 24.1 24 1 enlarged adrenal glands 0.570985296608335 0.936775313452746 0.752469911981319 0.263157894736842 24.1 24 1 unresponsive to tactile stimuli 0.570985296608335 0.936775313452746 0.752469911981319 0.263157894736842 24.1 24 1 abnormal long term depression 0.570985296608335 0.936775313452746 0.752469911981319 0.263157894736842 24.1 24 1 abnormal metatarsal bone morphology 0.570985296608335 0.936775313452746 0.752469911981319 0.263157894736842 24.1 24 1 abnormal optic vesicle formation 0.570985296608335 0.936775313452746 0.752469911981319 0.263157894736842 24.1 24 1 abnormal cochlear inner hair cell morphology 0.570985296608335 0.936775313452746 0.752469911981319 0.263157894736842 24.1 24 1 eyelids fail to open 0.570985296608335 0.936775313452746 0.752469911981319 0.263157894736842 24.1 24 1 decreased liver glycogen level 0.570985296608335 0.936775313452746 0.752469911981319 0.263157894736842 24.1 24 1 right-sided stomach 0.570985296608335 0.936775313452746 0.752469911981319 0.263157894736842 24.1 24 1 abnormal CNS synaptic transmission 0.506539576203885 0.882983318715601 0.750949770744993 0.262626262626263 24.1 24 1 abnormal social investigation 0.515091856330921 0.893820015781769 0.750588737201365 0.2625 24.1 24 1 decreased exploration in new environment 0.518358937389439 0.896986335134768 0.748886721924265 0.261904761904762 24.1 24 1 abnormal pulmonary artery morphology 0.571525768917289 0.936775313452746 0.745926695355394 0.260869565217391 24.1 24 1 abnormal innervation pattern to muscle 0.571525768917289 0.936775313452746 0.745926695355394 0.260869565217391 24.1 24 1 abnormal cranial nerve morphology 0.571525768917289 0.936775313452746 0.745926695355394 0.260869565217391 24.1 24 1 bidirectional circling 0.571525768917289 0.936775313452746 0.745926695355394 0.260869565217391 24.1 24 1 abnormal lens development 0.571525768917289 0.936775313452746 0.745926695355394 0.260869565217391 24.1 24 1 abnormal basicranium morphology 0.571525768917289 0.936775313452746 0.745926695355394 0.260869565217391 24.1 24 1 abnormal hepatocyte physiology 0.571525768917289 0.936775313452746 0.745926695355394 0.260869565217391 24.1 24 1 increased susceptibility to pharmacologically induced seizures 0.527360781621393 0.911929054072447 0.744631683731513 0.260416666666667 24.1 24 1 abnormal digestive system physiology 0.548214245740998 0.936775313452746 0.743440273037543 0.26 24.1 24 1 absent mature ovarian follicles 0.57360369884966 0.936775313452746 0.737905978201035 0.258064516129032 24.1 24 1 abnormal body temperature homeostasis 0.57360369884966 0.936775313452746 0.737905978201035 0.258064516129032 24.1 24 1 abnormal nose morphology 0.57360369884966 0.936775313452746 0.737905978201035 0.258064516129032 24.1 24 1 dehydration 0.560589180505291 0.936775313452746 0.73527059970746 0.257142857142857 24.1 24 1 abnormal artery morphology 0.574892845265754 0.936775313452746 0.73527059970746 0.257142857142857 24.1 24 1 holoprosencephaly 0.574892845265754 0.936775313452746 0.73527059970746 0.257142857142857 24.1 24 1 impaired behavioral response to xenobiotic 0.574892845265754 0.936775313452746 0.73527059970746 0.257142857142857 24.1 24 1 abnormal lens fiber morphology 0.576265834968111 0.936775313452746 0.733175811674105 0.256410256410256 24.1 24 1 cochlear inner hair cell degeneration 0.580609093438126 0.936775313452746 0.728863012781905 0.254901960784314 24.1 24 1 syndactyly 0.583551447930651 0.936775313452746 0.726962457337884 0.254237288135593 24.1 24 1 cochlear hair cell degeneration 0.611821900425907 0.965677016059292 0.714846416382253 0.25 24.1 24 1 abnormal jaw morphology 0.615178167499717 0.969129633727388 0.714846416382253 0.25 24.1 24 1 increased circulating luteinizing hormone level 0.615178167499717 0.969129633727388 0.714846416382253 0.25 24.1 24 1 abnormal respiration 0.615178167499717 0.969129633727388 0.714846416382253 0.25 24.1 24 1 abnormal retinal inner nuclear layer morphology 0.615178167499717 0.969129633727388 0.714846416382253 0.25 24.1 24 1 reduced long term potentiation 0.622714409628692 0.978523116835989 0.714846416382253 0.25 24.1 24 1 abnormal neuron differentiation 0.622714409628692 0.978523116835989 0.714846416382253 0.25 24.1 24 1 head tilt 0.612620553750801 0.966527556979027 0.714846416382253 0.25 24.1 24 1 decreased fatty acid level 0.617614384556752 0.972351760496786 0.714846416382253 0.25 24.1 24 1 abnormal lung saccule morphology 0.617614384556752 0.972351760496786 0.714846416382253 0.25 24.1 24 1 abnormal basioccipital bone morphology 0.621362636780451 0.977016156126026 0.714846416382253 0.25 24.1 24 1 abnormal hearing physiology 0.621362636780451 0.977016156126026 0.714846416382253 0.25 24.1 24 1 abnormal trachea morphology 0.621362636780451 0.977016156126026 0.714846416382253 0.25 24.1 24 1 decreased paired-pulse facilitation 0.621362636780451 0.977016156126026 0.714846416382253 0.25 24.1 24 1 abnormal kidney development 0.612749329590322 0.966527556979027 0.714846416382252 0.25 24.1 24 1 circling 0.64067122220662 0.997914630706929 0.706436458542461 0.247058823529412 24.1 24 1 organ of Corti degeneration 0.643222303826929 1 0.700257714007105 0.244897959183673 24.1 24 1 decreased urine osmolality 0.643222303826929 1 0.700257714007105 0.244897959183673 24.1 24 1 lethality at weaning, complete penetrance 0.644547659218629 1 0.698960940462647 0.244444444444444 24.1 24 1 deafness 0.684361570626783 1 0.693184403764609 0.242424242424242 24.1 24 1 abnormal aorta morphology 0.651534545237147 1 0.693184403764608 0.242424242424242 24.1 24 1 dilated heart atrium 0.651534545237147 1 0.693184403764608 0.242424242424242 24.1 24 1 abnormal middle ear morphology 0.655466874571765 1 0.690196539955278 0.241379310344828 24.1 24 1 abnormal long bone epiphyseal plate proliferative zone 0.671174205253135 1 0.68837062318291 0.240740740740741 24.1 24 1 abnormal energy expenditure 0.660746631241456 1 0.686252559726963 0.24 24.1 24 1 abnormal femur morphology 0.692205065712716 1 0.682838367887525 0.238805970149254 24.1 24 1 abnormal vibrissa morphology 0.6787717782216 1 0.680806110840241 0.238095238095238 24.1 24 1 hypoalgesia 0.668017471305264 1 0.680806110840241 0.238095238095238 24.1 24 1 abnormal retinal photoreceptor morphology 0.687203631767181 1 0.672796627183297 0.235294117647059 24.1 24 1 abnormal pain threshold 0.693102501665417 1 0.667189988623436 0.233333333333333 24.1 24 1 abnormal eye physiology 0.721625164816754 1 0.667189988623436 0.233333333333333 24.1 24 1 abnormal food intake 0.739218138908463 1 0.663045951427017 0.231884057971014 24.1 24 1 abnormal eye electrophysiology 0.786576173290783 1 0.661676021775308 0.231404958677686 24.1 24 1 abnormal kidney cortex morphology 0.700691259972625 1 0.659858230506695 0.230769230769231 24.1 24 1 abnormal excitatory postsynaptic currents 0.754980627146648 1 0.659858230506695 0.230769230769231 24.1 24 1 abnormal tectorial membrane morphology 0.700691259972625 1 0.659858230506695 0.230769230769231 24.1 24 1 increased percent body fat/body weight 0.72864015540079 1 0.659858230506695 0.230769230769231 24.1 24 1 abnormal facial nerve morphology 0.710716102530818 1 0.649860378529321 0.227272727272727 24.1 24 1 increased coping response 0.710716102530818 1 0.649860378529321 0.227272727272727 24.1 24 1 abnormal retinal layer morphology 0.710716102530818 1 0.649860378529321 0.227272727272727 24.1 24 1 abnormal photoreceptor outer segment morphology 0.738103074446115 1 0.649860378529321 0.227272727272727 24.1 24 1 impaired swimming 0.764382086317892 1 0.64986037852932 0.227272727272727 24.1 24 1 abnormal cranial ganglia morphology 0.727956319153346 1 0.645667730925906 0.225806451612903 24.1 24 1 abnormal intestine physiology 0.727956319153346 1 0.645667730925906 0.225806451612903 24.1 24 1 short radius 0.751298144153357 1 0.635419036784225 0.222222222222222 24.1 24 1 abnormal brain commissure morphology 0.737331158034907 1 0.635419036784224 0.222222222222222 24.1 24 1 abnormal excitatory postsynaptic potential 0.827326410274149 1 0.627670024140514 0.219512195121951 24.1 24 1 abnormal long term potentiation 0.759975391021613 1 0.625490614334471 0.21875 24.1 24 1 abnormal retinal cone cell morphology 0.749380084090131 1 0.621605579462828 0.217391304347826 24.1 24 1 impaired skeletal muscle contractility 0.779640102935606 1 0.61824554930357 0.216216216216216 24.1 24 1 abnormal pancreatic beta cell physiology 0.779640102935606 1 0.61824554930357 0.216216216216216 24.1 24 1 abnormal cued conditioning behavior 0.805583325937324 1 0.616730241584689 0.215686274509804 24.1 24 1 abnormal stria vascularis morphology 0.770645609999049 1 0.612725499756217 0.214285714285714 24.1 24 1 absent corpus callosum 0.770645609999049 1 0.612725499756217 0.214285714285714 24.1 24 1 decreased circulating progesterone level 0.770645609999049 1 0.612725499756217 0.214285714285714 24.1 24 1 increased systemic arterial blood pressure 0.812385615722057 1 0.60837992883596 0.212765957446809 24.1 24 1 apnea 0.784055268177863 1 0.59570534698521 0.208333333333333 24.1 24 1 decreased ovulation rate 0.784055268177863 1 0.59570534698521 0.208333333333333 24.1 24 1 abnormal osteoblast morphology 0.784055268177863 1 0.59570534698521 0.208333333333333 24.1 24 1 absent long term depression 0.800692236632254 1 0.591597034247381 0.206896551724138 24.1 24 1 abnormal cochlea morphology 0.862449299514789 1 0.582467450385539 0.203703703703704 24.1 24 1 abnormal inner ear vestibule morphology 0.814882427411965 1 0.571877133105802 0.2 24.1 24 1 diaphragmatic hernia 0.814882427411965 1 0.571877133105802 0.2 24.1 24 1 abnormal inner ear morphology 0.877547258909618 1 0.559445021516545 0.195652173913043 24.1 24 1 abnormal retinal photoreceptor layer morphology 0.851501674666911 1 0.553429483650776 0.193548387096774 24.1 24 1 abnormal ureter morphology 0.842070800611807 1 0.549881858755579 0.192307692307692 24.1 24 1 abnormal humerus morphology 0.879554408539041 1 0.540964855640624 0.189189189189189 24.1 24 1 abnormal serotonin level 0.872623124738903 1 0.536134812286689 0.1875 24.1 24 1 abnormal middle ear ossicle morphology 0.891168040603504 1 0.519888302823456 0.181818181818182 24.1 24 1 head tossing 0.891168040603504 1 0.519888302823456 0.181818181818182 24.1 24 1 abnormal inhibitory postsynaptic currents 0.959764159657917 1 0.504597470387472 0.176470588235294 24.1 24 1 abnormal bone remodeling 0.907359694610061 1 0.504597470387472 0.176470588235294 24.1 24 1 decreased pancreatic beta cell number 0.907359694610061 1 0.504597470387472 0.176470588235294 24.1 24 1 head bobbing 0.923843926357941 1 0.500392491467577 0.175 24.1 24 1 abnormal spinal nerve morphology 0.904470098519019 1 0.492997528539485 0.172413793103448 24.1 24 1 short ulna 0.935062604522467 1 0.488187796553733 0.170731707317073 24.1 24 1 abnormal reflex 0.933576897508791 1 0.476564277588168 0.166666666666667 24.1 24 1 abnormal limb bone morphology 0.933576897508791 1 0.476564277588168 0.166666666666667 24.1 24 1 abnormal axon guidance 0.95321153763846 1 0.465481387411699 0.162790697674419 24.1 24 1 abnormal retinal outer nuclear layer morphology 0.9529887457842 1 0.451481947188791 0.157894736842105 24.1 24 1 abnormal cartilage development 0.966667486311243 1 0.444793325748957 0.155555555555556 24.1 24 1 abnormal B cell proliferation 6.45941445404311e-05 0.000839049266549986 1.23389964440932 1 24.2 24 2 decreased red blood cell distribution width 6.45941445404311e-05 0.000839049266549986 1.23389964440932 1 24.2 24 2 non-obstructive hydrocephaly 0.00804231462405972 0.046777049633943 1.23389964440932 1 24.2 24 2 abnormal hippocampal fimbria morphology 0.00804231462405972 0.046777049633943 1.23389964440932 1 24.2 24 2 liver cirrhosis 0.00804231462405972 0.046777049633943 1.23389964440932 1 24.2 24 2 enlarged pancreas 0.00804231462405972 0.046777049633943 1.23389964440932 1 24.2 24 2 abnormal leukocyte tethering or rolling 0.00804231462405972 0.046777049633943 1.23389964440932 1 24.2 24 2 abnormal extensor digitorum longus morphology 0.00804231462405972 0.046777049633943 1.23389964440932 1 24.2 24 2 abnormal immature B cell morphology 0.00804231462405972 0.046777049633943 1.23389964440932 1 24.2 24 2 impaired granulocyte bactericidal activity 0.00804231462405972 0.046777049633943 1.23389964440932 1 24.2 24 2 osteomyelitis 0.00804231462405972 0.046777049633943 1.23389964440932 1 24.2 24 2 abnormal olfactory bulb layer morphology 0.00804231462405972 0.046777049633943 1.23389964440932 1 24.2 24 2 abnormal orbit morphology 0.00804231462405972 0.046777049633943 1.23389964440932 1 24.2 24 2 thymus cortex atrophy 0.00804231462405972 0.046777049633943 1.23389964440932 1 24.2 24 2 additional anastomosis between intracranial vertebral arteries 0.00804231462405972 0.046777049633943 1.23389964440932 1 24.2 24 2 increased hemangioma incidence 1.29321486530056e-05 0.000201684763475557 1.23389964440932 1 24.2 24 2 multiple persisting craniopharyngeal ducts 1.29321486530056e-05 0.000201684763475557 1.23389964440932 1 24.2 24 2 increased neuronal precursor cell number 0.000720872148213292 0.00648524220137636 1.23389964440932 1 24.2 24 2 decreased susceptibility to atherosclerosis 0.000720872148213292 0.00648524220137636 1.23389964440932 1 24.2 24 2 decreased transitional stage T1 B cell number 0.000720872148213292 0.00648524220137636 1.23389964440932 1 24.2 24 2 elevated level of mitotic sister chromatid exchange 0.00161082486353946 0.0124053462788062 1.23389964440932 1 24.2 24 2 absent interparietal bone 0.00161082486353946 0.0124053462788062 1.23389964440932 1 24.2 24 2 accumulation of giant lysosomes in kidney/renal tubule cells 0.00161082486353946 0.0124053462788062 1.23389964440932 1 24.2 24 2 abnormal NK cell morphology 0.00161082486353946 0.0124053462788062 1.23389964440932 1 24.2 24 2 abnormal olfactory bulb mitral cell layer morphology 0.00161082486353946 0.0124053462788062 1.23389964440932 1 24.2 24 2 abnormal umbilical vein topology 0.00161082486353946 0.0124053462788062 1.23389964440932 1 24.2 24 2 broad head 0.00359933769659846 0.023971492691536 1.23389964440932 1 24.2 24 2 mammary gland hyperplasia 0.00359933769659846 0.023971492691536 1.23389964440932 1 24.2 24 2 abnormal circulating alanine transaminase level 0.00359933769659846 0.023971492691536 1.23389964440932 1 24.2 24 2 decreased activated T cell number 0.00359933769659846 0.023971492691536 1.23389964440932 1 24.2 24 2 abnormal brain ventricular system morphology 0.00359933769659846 0.023971492691536 1.23389964440932 1 24.2 24 2 decreased mortality induced by ionizing radiation 0.00359933769659846 0.023971492691536 1.23389964440932 1 24.2 24 2 decreased cardiomyocyte apoptosis 0.00359933769659846 0.023971492691536 1.23389964440932 1 24.2 24 2 aorta coarctation 0.00359933769659846 0.023971492691536 1.23389964440932 1 24.2 24 2 heart hemorrhage 0.00359933769659846 0.023971492691536 1.23389964440932 1 24.2 24 2 decreased DN2 thymocyte number 0.00359933769659846 0.023971492691536 1.23389964440932 1 24.2 24 2 decreased brain cholesterol level 0.00359933769659846 0.023971492691536 1.23389964440932 1 24.2 24 2 ductus venosus stenosis 0.00359933769659846 0.023971492691536 1.23389964440932 1 24.2 24 2 increased skin tumor incidence 1.03686842667857e-07 2.81880897416716e-06 1.23389964440932 1 24.2 24 2 increased number of Howell-Jolly bodies 0.000144354611123535 0.00163590931740225 1.23389964440932 1 24.2 24 2 abnormal plasma membrane morphology 0.000322591083397704 0.00324220331293652 1.23389964440932 1 24.2 24 2 increased platelet aggregation 0.000322591083397704 0.00324220331293652 1.23389964440932 1 24.2 24 2 decreased transitional stage T2 B cell number 0.000322591083397704 0.00324220331293652 1.23389964440932 1 24.2 24 2 abnormal left subclavian artery morphology 0.000322591083397704 0.00324220331293652 1.23389964440932 1 24.2 24 2 abnormal inferior vena cava valve morphology 0.000322591083397704 0.00324220331293652 1.23389964440932 1 24.2 24 2 thin ventricle myocardium compact layer 0.000322591083397704 0.00324220331293652 1.23389964440932 1 24.2 24 2 absent ribs 0.0179689921436981 0.0844950244942328 1.23389964440932 1 24.2 24 2 small hair follicles 0.0179689921436981 0.0844950244942328 1.23389964440932 1 24.2 24 2 absent lungs 0.0179689921436981 0.0844950244942328 1.23389964440932 1 24.2 24 2 decreased sensitivity to skin irradiation 0.0179689921436981 0.0844950244942328 1.23389964440932 1 24.2 24 2 abnormal respiratory sounds 0.0179689921436981 0.0844950244942328 1.23389964440932 1 24.2 24 2 decreased lysosomal enzyme secretion 0.0179689921436981 0.0844950244942328 1.23389964440932 1 24.2 24 2 increased lysosomal enzyme secretion 0.0179689921436981 0.0844950244942328 1.23389964440932 1 24.2 24 2 gastric polyps 0.0179689921436981 0.0844950244942328 1.23389964440932 1 24.2 24 2 increased heart right ventricle weight 0.0179689921436981 0.0844950244942328 1.23389964440932 1 24.2 24 2 abnormal inner cell mass proliferation 0.0179689921436981 0.0844950244942328 1.23389964440932 1 24.2 24 2 decreased leukotriene level 0.0179689921436981 0.0844950244942328 1.23389964440932 1 24.2 24 2 aciduria 0.0179689921436981 0.0844950244942328 1.23389964440932 1 24.2 24 2 decreased DN3 thymocyte number 0.0179689921436981 0.0844950244942328 1.23389964440932 1 24.2 24 2 hemolysis 0.0179689921436981 0.0844950244942328 1.23389964440932 1 24.2 24 2 increased response to stress-induced hyperthermia 0.0179689921436981 0.0844950244942328 1.23389964440932 1 24.2 24 2 aorta hypoplasia 0.0179689921436981 0.0844950244942328 1.23389964440932 1 24.2 24 2 prolonged ST segment 0.0179689921436981 0.0844950244942328 1.23389964440932 1 24.2 24 2 decreased heart left ventricle size 0.0179689921436981 0.0844950244942328 1.23389964440932 1 24.2 24 2 abnormal circadian regulation of systemic arterial blood pressure 0.0179689921436981 0.0844950244942328 1.23389964440932 1 24.2 24 2 increased macrophage cytokine production 0.0179689921436981 0.0844950244942328 1.23389964440932 1 24.2 24 2 decreased pre-pro B cell number 0.0179689921436981 0.0844950244942328 1.23389964440932 1 24.2 24 2 delayed optic fissure closure 0.0179689921436981 0.0844950244942328 1.23389964440932 1 24.2 24 2 decreased small intestinal villus height 0.0179689921436981 0.0844950244942328 1.23389964440932 1 24.2 24 2 decreased fibroblast chemotaxis 0.0179689921436981 0.0844950244942328 1.23389964440932 1 24.2 24 2 embryonic lethality between implantation and placentation, complete penetrance 1.38775889029927e-13 9.08434273584062e-12 1.18025183378283 0.956521739130435 24.2 24 2 decreased cellular sensitivity to gamma-irradiation 1.20387171264853e-05 0.00018953360032995 1.16534966416436 0.944444444444444 24.2 24 2 absent inner cell mass 1.20387171264853e-05 0.00018953360032995 1.16534966416436 0.944444444444444 24.2 24 2 abnormal dorsal-ventral axis patterning 2.5477676171118e-05 0.00037389805000387 1.16131731238525 0.941176470588235 24.2 24 2 decreased liver cholesterol level 5.37467675460003e-05 0.000711144065269552 1.15678091663374 0.9375 24.2 24 2 decreased hepatocyte number 0.000112976867627947 0.00135110556838711 1.15163966811537 0.933333333333333 24.2 24 2 decreased thymocyte apoptosis 0.000112976867627947 0.00135110556838711 1.15163966811537 0.933333333333333 24.2 24 2 heterochrony 0.000112976867627947 0.00135110556838711 1.15163966811537 0.933333333333333 24.2 24 2 abnormal spleen periarteriolar lymphoid sheath morphology 0.000236521183151144 0.00253597604779513 1.14576395552294 0.928571428571429 24.2 24 2 abnormal vascular endothelial cell migration 0.000236521183151144 0.00253597604779513 1.14576395552294 0.928571428571429 24.2 24 2 absent common myeloid progenitor cells 0.000492890351333988 0.00467963644634846 1.13898428714707 0.923076923076923 24.2 24 2 axonal dystrophy 0.000492890351333988 0.00467963644634846 1.13898428714707 0.923076923076923 24.2 24 2 impaired hematopoiesis 9.45330941683929e-13 5.40577176422706e-11 1.13712320171055 0.92156862745098 24.2 24 2 increased cellular sensitivity to ionizing radiation 9.09700836756824e-07 1.91769561985814e-05 1.13518767285658 0.92 24.2 24 2 increased hemangiosarcoma incidence 1.87646328267847e-06 3.67535623280527e-05 1.13107467404188 0.916666666666667 24.2 24 2 myocarditis 0.00102171974353768 0.00861534868491514 1.13107467404188 0.916666666666667 24.2 24 2 abnormal embryonic growth/weight/body size 0.00102171974353768 0.00861534868491514 1.13107467404188 0.916666666666667 24.2 24 2 small intestinal inflammation 0.00102171974353768 0.00861534868491514 1.13107467404188 0.916666666666667 24.2 24 2 increased osteosarcoma incidence 0.00102171974353768 0.00861534868491514 1.13107467404188 0.916666666666667 24.2 24 2 abnormal nucleotide metabolism 0.00102171974353768 0.00861534868491514 1.13107467404188 0.916666666666667 24.2 24 2 increased fibrosarcoma incidence 0.00102171974353768 0.00861534868491514 1.13107467404188 0.916666666666667 24.2 24 2 abnormal vitelline vein connection 0.00102171974353768 0.00861534868491514 1.13107467404188 0.916666666666667 24.2 24 2 abnormal sphenoid bone morphology 0.0021049558061394 0.0151990640573926 1.12172694946302 0.909090909090909 24.2 24 2 abnormal hemoglobin 0.0021049558061394 0.0151990640573926 1.12172694946302 0.909090909090909 24.2 24 2 loss of cortex neurons 0.0021049558061394 0.0151990640573926 1.12172694946302 0.909090909090909 24.2 24 2 pharyngeal arch hypoplasia 0.0021049558061394 0.0151990640573926 1.12172694946302 0.909090909090909 24.2 24 2 increased glycogen level 0.0021049558061394 0.0151990640573926 1.12172694946302 0.909090909090909 24.2 24 2 chylous ascites 0.0021049558061394 0.0151990640573926 1.12172694946302 0.909090909090909 24.2 24 2 thin hypoglossal nerve 0.0021049558061394 0.0151990640573926 1.12172694946302 0.909090909090909 24.2 24 2 reduced sympathetic cervical ganglion size 0.0021049558061394 0.0151990640573926 1.12172694946302 0.909090909090909 24.2 24 2 abnormal erythropoiesis 5.01060534782466e-23 1.08381572197512e-20 1.11638539256082 0.904761904761905 24.2 24 2 increased B cell derived lymphoma incidence 2.26733320733683e-11 1.05420399126175e-09 1.11050967996839 0.9 24.2 24 2 decreased myocardial infarction size 3.27314596312639e-05 0.000457412954116679 1.11050967996839 0.9 24.2 24 2 absent ductus venosus valve 3.27314596312639e-05 0.000457412954116679 1.11050967996839 0.9 24.2 24 2 retarded hair growth 0.00430540173155359 0.027889809393853 1.11050967996839 0.9 24.2 24 2 kidney hemorrhage 0.00430540173155359 0.027889809393853 1.11050967996839 0.9 24.2 24 2 abnormal immune cell physiology 0.00430540173155359 0.027889809393853 1.11050967996839 0.9 24.2 24 2 acrania 0.00430540173155359 0.027889809393853 1.11050967996839 0.9 24.2 24 2 abnormal reproductive system development 0.00430540173155359 0.027889809393853 1.11050967996839 0.9 24.2 24 2 abnormal gas homeostasis 0.00430540173155359 0.027889809393853 1.11050967996839 0.9 24.2 24 2 osteosclerosis 0.00430540173155359 0.027889809393853 1.11050967996839 0.9 24.2 24 2 acanthocytosis 0.00430540173155359 0.027889809393853 1.11050967996839 0.9 24.2 24 2 abnormal vibrissa follicle morphology 0.00430540173155359 0.027889809393853 1.11050967996839 0.9 24.2 24 2 lethality during fetal growth through weaning, complete penetrance 0.00430540173155359 0.027889809393853 1.11050967996839 0.9 24.2 24 2 increased mortality induced by gamma-irradiation 5.61180923694958e-07 1.24083337572552e-05 1.10625485360836 0.896551724137931 24.2 24 2 incomplete embryo turning 1.72228939131143e-12 9.41581288107072e-11 1.10401547131361 0.894736842105263 24.2 24 2 increased liver adenoma incidence 6.61536548473517e-05 0.000857068835587435 1.10401547131361 0.894736842105263 24.2 24 2 subcutaneous edema 1.12884708500135e-06 2.34979675643587e-05 1.10169611107975 0.892857142857143 24.2 24 2 abnormal megakaryocyte differentiation 0.00013298934852818 0.00151748167185251 1.0967996839194 0.888888888888889 24.2 24 2 abnormal aerobic respiration 0.00013298934852818 0.00151748167185251 1.0967996839194 0.888888888888889 24.2 24 2 abnormal hypoglossal nerve topology 0.00013298934852818 0.00151748167185251 1.0967996839194 0.888888888888889 24.2 24 2 abnormal cholinergic neuron morphology 0.00873044658614885 0.0489672736934504 1.0967996839194 0.888888888888889 24.2 24 2 polycythemia 0.00873044658614885 0.0489672736934504 1.0967996839194 0.888888888888889 24.2 24 2 abnormal artery development 0.00873044658614885 0.0489672736934504 1.0967996839194 0.888888888888889 24.2 24 2 premature bone ossification 0.00873044658614885 0.0489672736934504 1.0967996839194 0.888888888888889 24.2 24 2 abnormal thymus physiology 0.00873044658614885 0.0489672736934504 1.0967996839194 0.888888888888889 24.2 24 2 decreased cellular sensitivity to ionizing radiation 0.00873044658614885 0.0489672736934504 1.0967996839194 0.888888888888889 24.2 24 2 liver hyperplasia 0.00873044658614885 0.0489672736934504 1.0967996839194 0.888888888888889 24.2 24 2 abnormal inguinal fat pad morphology 0.00873044658614885 0.0489672736934504 1.0967996839194 0.888888888888889 24.2 24 2 eye opacity 0.00873044658614885 0.0489672736934504 1.0967996839194 0.888888888888889 24.2 24 2 decreased effector memory CD4-positive, alpha-beta T cell number 0.00873044658614885 0.0489672736934504 1.0967996839194 0.888888888888889 24.2 24 2 abnormal oxidative phosphorylation 0.00873044658614885 0.0489672736934504 1.0967996839194 0.888888888888889 24.2 24 2 trigeminal neuroma 0.00873044658614885 0.0489672736934504 1.0967996839194 0.888888888888889 24.2 24 2 decreased platelet dense granule number 0.00873044658614885 0.0489672736934504 1.0967996839194 0.888888888888889 24.2 24 2 decreased B cell proliferation 3.75511456742373e-16 4.06123803759415e-14 1.09332879884371 0.886075949367089 24.2 24 2 decreased bone resorption 4.51354011666572e-06 8.00475090265532e-05 1.09152660851594 0.884615384615385 24.2 24 2 abnormal ductus venosus valve morphology 0.000265764952857618 0.00279530790796332 1.08873498036117 0.882352941176471 24.2 24 2 increased B cell proliferation 4.06142317688134e-12 2.14952981967922e-10 1.08750477134381 0.88135593220339 24.2 24 2 ruffled hair 8.96605455277053e-06 0.000148687071333445 1.08583168708021 0.88 24.2 24 2 increased pre-B cell number 8.96605455277053e-06 0.000148687071333445 1.08583168708021 0.88 24.2 24 2 abnormal cell cycle 4.72635617751406e-22 9.04370076274326e-20 1.08368577465515 0.878260869565217 24.2 24 2 decreased mast cell number 0.000527587568201572 0.00495235500340155 1.07966218885816 0.875 24.2 24 2 disorganized yolk sac vascular plexus 0.000527587568201572 0.00495235500340155 1.07966218885816 0.875 24.2 24 2 kidney degeneration 0.000527587568201572 0.00495235500340155 1.07966218885816 0.875 24.2 24 2 abnormal exoccipital bone morphology 0.0175189275280114 0.0843723760424559 1.07966218885816 0.875 24.2 24 2 failure of vascular branching 0.0175189275280114 0.0843723760424559 1.07966218885816 0.875 24.2 24 2 schistocytosis 0.0175189275280114 0.0843723760424559 1.07966218885816 0.875 24.2 24 2 increased sensitivity to skin irradiation 0.0175189275280114 0.0843723760424559 1.07966218885816 0.875 24.2 24 2 abnormal pupil morphology 0.0175189275280114 0.0843723760424559 1.07966218885816 0.875 24.2 24 2 abnormal erythrocyte cell number 0.0175189275280114 0.0843723760424559 1.07966218885816 0.875 24.2 24 2 abnormal pulmonary circulation 0.0175189275280114 0.0843723760424559 1.07966218885816 0.875 24.2 24 2 altered response to CNS ischemic injury 0.0175189275280114 0.0843723760424559 1.07966218885816 0.875 24.2 24 2 colon polyps 0.0175189275280114 0.0843723760424559 1.07966218885816 0.875 24.2 24 2 liver failure 0.0175189275280114 0.0843723760424559 1.07966218885816 0.875 24.2 24 2 increased cardiac output 0.0175189275280114 0.0843723760424559 1.07966218885816 0.875 24.2 24 2 abnormal ovary development 0.0175189275280114 0.0843723760424559 1.07966218885816 0.875 24.2 24 2 lymph node inflammation 0.0175189275280114 0.0843723760424559 1.07966218885816 0.875 24.2 24 2 tau protein deposits 0.0175189275280114 0.0843723760424559 1.07966218885816 0.875 24.2 24 2 abnormal extraembryonic tissue physiology 0.0175189275280114 0.0843723760424559 1.07966218885816 0.875 24.2 24 2 abnormal kidney epithelium morphology 0.0175189275280114 0.0843723760424559 1.07966218885816 0.875 24.2 24 2 abnormal choroid pigmentation 0.0175189275280114 0.0843723760424559 1.07966218885816 0.875 24.2 24 2 abnormal somite size 0.0175189275280114 0.0843723760424559 1.07966218885816 0.875 24.2 24 2 abnormal vertebral body development 0.0175189275280114 0.0843723760424559 1.07966218885816 0.875 24.2 24 2 craniofacial phenotype 0.0175189275280114 0.0843723760424559 1.07966218885816 0.875 24.2 24 2 abnormal epidermal lamellar body morphology 0.0175189275280114 0.0843723760424559 1.07966218885816 0.875 24.2 24 2 abnormal meiotic spindle morphology 0.0175189275280114 0.0843723760424559 1.07966218885816 0.875 24.2 24 2 abnormal mitotic spindle assembly checkpoint 0.0175189275280114 0.0843723760424559 1.07966218885816 0.875 24.2 24 2 abnormal base-excision repair 0.0175189275280114 0.0843723760424559 1.07966218885816 0.875 24.2 24 2 abnormal sphingomyelin level 0.0175189275280114 0.0843723760424559 1.07966218885816 0.875 24.2 24 2 abnormal cerebellum deep nucleus morphology 0.0175189275280114 0.0843723760424559 1.07966218885816 0.875 24.2 24 2 decreased susceptibility to weight loss 0.0175189275280114 0.0843723760424559 1.07966218885816 0.875 24.2 24 2 abnormal circulating serum amyloid protein level 0.0175189275280114 0.0843723760424559 1.07966218885816 0.875 24.2 24 2 decreased quadriceps weight 0.0175189275280114 0.0843723760424559 1.07966218885816 0.875 24.2 24 2 increased susceptibility to parasitic infection induced morbidity/mortality 0.0175189275280114 0.0843723760424559 1.07966218885816 0.875 24.2 24 2 decreased alveolar lamellar body number 0.0175189275280114 0.0843723760424559 1.07966218885816 0.875 24.2 24 2 abnormal foramen magnum morphology 0.0175189275280114 0.0843723760424559 1.07966218885816 0.875 24.2 24 2 increased aorta wall thickness 0.0175189275280114 0.0843723760424559 1.07966218885816 0.875 24.2 24 2 abnormal macrophage activation involved in immune response 0.0175189275280114 0.0843723760424559 1.07966218885816 0.875 24.2 24 2 increased circulating ferritin level 0.0175189275280114 0.0843723760424559 1.07966218885816 0.875 24.2 24 2 increased cardiac stroke volume 0.0175189275280114 0.0843723760424559 1.07966218885816 0.875 24.2 24 2 embryo cyst 0.0175189275280114 0.0843723760424559 1.07966218885816 0.875 24.2 24 2 increased brain apoptosis 0.0175189275280114 0.0843723760424559 1.07966218885816 0.875 24.2 24 2 decreased vascular endothelial cell proliferation 0.0175189275280114 0.0843723760424559 1.07966218885816 0.875 24.2 24 2 abnormal platelet physiology 6.112103752073e-11 2.71497465772886e-09 1.0768578714845 0.872727272727273 24.2 24 2 embryonic lethality between somite formation and embryo turning, complete penetrance 1.70264994213014e-13 1.10008876131135e-11 1.07525540441384 0.871428571428571 24.2 24 2 abnormal T cell proliferation 1.22802236999425e-06 2.50385708636122e-05 1.07468678706619 0.870967741935484 24.2 24 2 increased susceptibility to fungal infection 3.48550760594321e-05 0.000475079461358013 1.07295621252985 0.869565217391304 24.2 24 2 abnormal vertebral artery topology 3.48550760594321e-05 0.000475079461358013 1.07295621252985 0.869565217391304 24.2 24 2 abnormal B cell differentiation 7.0388700473654e-17 8.75459462141071e-15 1.07118760338831 0.868131868131868 24.2 24 2 extramedullary hematopoiesis 2.02333458173e-19 3.3341753434511e-17 1.07093176684583 0.867924528301887 24.2 24 2 pale yolk sac 1.83798457091952e-15 1.69332837783789e-13 1.07037077587315 0.867469879518072 24.2 24 2 abnormal brain vasculature morphology 2.40205135794354e-06 4.61335546352559e-05 1.06937969182141 0.866666666666667 24.2 24 2 macrocytosis 0.00103955923405193 0.00869211292337537 1.06937969182141 0.866666666666667 24.2 24 2 abnormal lymph node B cell domain morphology 0.00103955923405193 0.00869211292337537 1.06937969182141 0.866666666666667 24.2 24 2 delayed intramembranous bone ossification 0.00103955923405193 0.00869211292337537 1.06937969182141 0.866666666666667 24.2 24 2 abnormal trophectoderm morphology 0.00103955923405193 0.00869211292337537 1.06937969182141 0.866666666666667 24.2 24 2 immune system phenotype 0.00103955923405193 0.00869211292337537 1.06937969182141 0.866666666666667 24.2 24 2 pale liver 9.35259211041501e-14 6.64702082133067e-12 1.06715644921887 0.864864864864865 24.2 24 2 abnormal myelopoiesis 1.21737509705137e-08 3.7852756923941e-07 1.06564060198987 0.863636363636364 24.2 24 2 increased skin papilloma incidence 6.81504703462106e-05 0.000878364222726418 1.06564060198987 0.863636363636364 24.2 24 2 abnormal lysosome physiology 6.81504703462106e-05 0.000878364222726418 1.06564060198987 0.863636363636364 24.2 24 2 decreased trophoblast giant cell number 4.67676059316633e-06 8.13527410874212e-05 1.06370659000804 0.862068965517241 24.2 24 2 blood in lymph vessels 4.67676059316633e-06 8.13527410874212e-05 1.06370659000804 0.862068965517241 24.2 24 2 abnormal lysosome morphology 3.2943237439611e-07 7.80440982200308e-06 1.06252469379692 0.861111111111111 24.2 24 2 increased hepatocellular carcinoma incidence 1.2493754122676e-10 5.1797022300261e-09 1.06072074694837 0.859649122807018 24.2 24 2 small liver 5.03139624807208e-14 3.95569323294845e-12 1.05988815609519 0.858974358974359 24.2 24 2 increased T cell derived lymphoma incidence 3.30007859270845e-09 1.14013131935587e-07 1.05762826663656 0.857142857142857 24.2 24 2 increased red blood cell distribution width 6.37077944852428e-07 1.3840448801925e-05 1.05762826663656 0.857142857142857 24.2 24 2 abnormal blood flow velocity 0.00203110536043106 0.0149257742513213 1.05762826663656 0.857142857142857 24.2 24 2 increased lactate dehydrogenase level 0.00203110536043106 0.0149257742513213 1.05762826663656 0.857142857142857 24.2 24 2 vascular smooth muscle hypoplasia 0.00203110536043106 0.0149257742513213 1.05762826663656 0.857142857142857 24.2 24 2 abnormal sagittal suture morphology 0.00203110536043106 0.0149257742513213 1.05762826663656 0.857142857142857 24.2 24 2 lysosomal protein accumulation 0.00203110536043106 0.0149257742513213 1.05762826663656 0.857142857142857 24.2 24 2 increased stomach tumor incidence 0.00203110536043106 0.0149257742513213 1.05762826663656 0.857142857142857 24.2 24 2 abnormal vitelline vein topology 0.00203110536043106 0.0149257742513213 1.05762826663656 0.857142857142857 24.2 24 2 decreased response to antigen 0.00203110536043106 0.0149257742513213 1.05762826663656 0.857142857142857 24.2 24 2 cellular necrosis 0.0347001761888273 0.143741362647307 1.05762826663656 0.857142857142857 24.2 24 2 abnormal circulating free fatty acids level 0.0347001761888273 0.143741362647307 1.05762826663656 0.857142857142857 24.2 24 2 abnormal tumor incidence 0.0347001761888273 0.143741362647307 1.05762826663656 0.857142857142857 24.2 24 2 abnormal hypersensitivity reaction 0.0347001761888273 0.143741362647307 1.05762826663656 0.857142857142857 24.2 24 2 abnormal gastrulation movements 0.0347001761888273 0.143741362647307 1.05762826663656 0.857142857142857 24.2 24 2 abnormal lymph node primary follicle morphology 0.0347001761888273 0.143741362647307 1.05762826663656 0.857142857142857 24.2 24 2 abnormal melanocyte morphology 0.0347001761888273 0.143741362647307 1.05762826663656 0.857142857142857 24.2 24 2 decreased cholesterol efflux 0.0347001761888273 0.143741362647307 1.05762826663656 0.857142857142857 24.2 24 2 increased cell nucleus count 0.0347001761888273 0.143741362647307 1.05762826663656 0.857142857142857 24.2 24 2 atherosclerotic lesions 0.0347001761888273 0.143741362647307 1.05762826663656 0.857142857142857 24.2 24 2 increased tumor latency 0.0347001761888273 0.143741362647307 1.05762826663656 0.857142857142857 24.2 24 2 decreased DN4 thymocyte number 0.0347001761888273 0.143741362647307 1.05762826663656 0.857142857142857 24.2 24 2 arteritis 0.0347001761888273 0.143741362647307 1.05762826663656 0.857142857142857 24.2 24 2 altered tumor pathology 0.0347001761888273 0.143741362647307 1.05762826663656 0.857142857142857 24.2 24 2 abnormal outer hair cell kinocilium morphology 0.0347001761888273 0.143741362647307 1.05762826663656 0.857142857142857 24.2 24 2 embryonic lethality at implantation, incomplete penetrance 0.0347001761888273 0.143741362647307 1.05762826663656 0.857142857142857 24.2 24 2 absent heart tube 0.0347001761888273 0.143741362647307 1.05762826663656 0.857142857142857 24.2 24 2 embryo tumor 0.0347001761888273 0.143741362647307 1.05762826663656 0.857142857142857 24.2 24 2 abnormal hematopoietic system physiology 0.000132421030032562 0.00151748167185251 1.05762826663656 0.857142857142857 24.2 24 2 increased incidence of induced tumors 0.000132421030032562 0.00151748167185251 1.05762826663656 0.857142857142857 24.2 24 2 abnormal tumor vascularization 0.000132421030032562 0.00151748167185251 1.05762826663656 0.857142857142857 24.2 24 2 absent segment of posterior cerebral artery 0.000132421030032562 0.00151748167185251 1.05762826663656 0.857142857142857 24.2 24 2 enlarged liver sinusoidal spaces 1.22666695533476e-06 2.50385708636122e-05 1.05244381434913 0.852941176470588 24.2 24 2 abnormal spleen red pulp morphology 1.22666695533476e-06 2.50385708636122e-05 1.05244381434913 0.852941176470588 24.2 24 2 decreased tumor growth/size 8.88924254029416e-10 3.37587646091324e-08 1.05109969708942 0.851851851851852 24.2 24 2 increased cellular sensitivity to gamma-irradiation 1.21730967139951e-08 3.7852756923941e-07 1.05012735694411 0.851063829787234 24.2 24 2 abnormal vascular regression 0.000255546094405185 0.00271075014854114 1.04881469774793 0.85 24.2 24 2 increased mammary adenocarcinoma incidence 0.000255546094405185 0.00271075014854114 1.04881469774793 0.85 24.2 24 2 abnormal thymocyte activation 0.000255546094405185 0.00271075014854114 1.04881469774793 0.85 24.2 24 2 liver hypoplasia 3.23916717826664e-09 1.12691305677458e-07 1.04406892988481 0.846153846153846 24.2 24 2 decreased B-1 B cell number 3.21040998968052e-07 7.64200464050745e-06 1.04406892988481 0.846153846153846 24.2 24 2 heart inflammation 3.34548839513469e-05 0.000463615731637746 1.04406892988481 0.846153846153846 24.2 24 2 increased leukemia incidence 3.34548839513469e-05 0.000463615731637746 1.04406892988481 0.846153846153846 24.2 24 2 decreased circulating glycerol level 3.34548839513469e-05 0.000463615731637746 1.04406892988481 0.846153846153846 24.2 24 2 increased foot pad pigmentation 0.00393028140065794 0.0259325596396197 1.04406892988481 0.846153846153846 24.2 24 2 abnormal exocrine pancreas morphology 0.00393028140065794 0.0259325596396197 1.04406892988481 0.846153846153846 24.2 24 2 increased prostaglandin level 0.00393028140065794 0.0259325596396197 1.04406892988481 0.846153846153846 24.2 24 2 absent hypoglossal nerve 0.00393028140065794 0.0259325596396197 1.04406892988481 0.846153846153846 24.2 24 2 abnormal embryonic hematopoiesis 4.48383721776013e-06 8.00475090265532e-05 1.04110282497037 0.84375 24.2 24 2 increased fibroblast apoptosis 4.48383721776013e-06 8.00475090265532e-05 1.04110282497037 0.84375 24.2 24 2 abnormal extraembryonic tissue morphology 1.44971391563935e-16 1.63916516597858e-14 1.04034675901178 0.843137254901961 24.2 24 2 abnormal cell morphology 2.95354202198916e-18 4.32172692923414e-16 1.03907338476575 0.842105263157895 24.2 24 2 small superior vagus ganglion 0.000489446381492594 0.00466474281211811 1.03907338476575 0.842105263157895 24.2 24 2 decreased tumor incidence 0.000489446381492594 0.00466474281211811 1.03907338476575 0.842105263157895 24.2 24 2 abnormal blastocyst morphology 0.000489446381492594 0.00466474281211811 1.03907338476575 0.842105263157895 24.2 24 2 absent amnion 0.000489446381492594 0.00466474281211811 1.03907338476575 0.842105263157895 24.2 24 2 decreased liver regeneration 0.000489446381492594 0.00466474281211811 1.03907338476575 0.842105263157895 24.2 24 2 embryonic lethality between implantation and somite formation, incomplete penetrance 0.000489446381492594 0.00466474281211811 1.03907338476575 0.842105263157895 24.2 24 2 abnormal egg cylinder morphology 6.37070257220645e-05 0.000831869955294674 1.03647570130383 0.84 24.2 24 2 decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 6.37070257220645e-05 0.000831869955294674 1.03647570130383 0.84 24.2 24 2 spleen hyperplasia 2.4028646687831e-12 1.29937518773869e-10 1.03647570130383 0.84 24.2 24 2 increased neuron apoptosis 3.40301885108506e-13 2.06463643709124e-11 1.0358663681461 0.839506172839506 24.2 24 2 abnormal object recognition memory 8.50700209527981e-06 0.000142021259812138 1.0348835727304 0.838709677419355 24.2 24 2 inner cell mass degeneration 8.50700209527981e-06 0.000142021259812138 1.0348835727304 0.838709677419355 24.2 24 2 decreased circulating total protein level 3.06321776065999e-09 1.07320481403405e-07 1.03198879350598 0.836363636363636 24.2 24 2 decreased erythrocyte cell number 1.21753796756634e-23 2.88440542316312e-21 1.02955957590842 0.834394904458599 24.2 24 2 abnormal cell adhesion 5.75275894589768e-09 1.89536263283715e-07 1.02824970367444 0.833333333333333 24.2 24 2 vertebral transformation 4.1294834633091e-08 1.18752486878397e-06 1.02824970367444 0.833333333333333 24.2 24 2 decreased metastatic potential 0.000120507406657305 0.00143084569957063 1.02824970367444 0.833333333333333 24.2 24 2 abnormal tumor morphology 0.000120507406657305 0.00143084569957063 1.02824970367444 0.833333333333333 24.2 24 2 increased body temperature 0.000120507406657305 0.00143084569957063 1.02824970367444 0.833333333333333 24.2 24 2 long tibia 0.000929642974504809 0.00798786493637552 1.02824970367444 0.833333333333333 24.2 24 2 abnormal neutrophil morphology 0.000929642974504809 0.00798786493637552 1.02824970367444 0.833333333333333 24.2 24 2 primary atelectasis 0.000929642974504809 0.00798786493637552 1.02824970367444 0.833333333333333 24.2 24 2 increased effector memory CD4-positive, alpha-beta T cell number 0.000929642974504809 0.00798786493637552 1.02824970367444 0.833333333333333 24.2 24 2 increased effector memory CD8-positive, alpha-beta T cell number 0.000929642974504809 0.00798786493637552 1.02824970367444 0.833333333333333 24.2 24 2 impaired leukocyte tethering or rolling 0.000929642974504809 0.00798786493637552 1.02824970367444 0.833333333333333 24.2 24 2 abnormal thymus involution 0.00752113611914801 0.0445979167970934 1.02824970367444 0.833333333333333 24.2 24 2 altered tumor susceptibility 0.00752113611914801 0.0445979167970934 1.02824970367444 0.833333333333333 24.2 24 2 abnormal vascular endothelial cell development 0.00752113611914801 0.0445979167970934 1.02824970367444 0.833333333333333 24.2 24 2 abnormal defecation 0.00752113611914801 0.0445979167970934 1.02824970367444 0.833333333333333 24.2 24 2 pale placenta 0.00752113611914801 0.0445979167970934 1.02824970367444 0.833333333333333 24.2 24 2 absent organized vascular network 0.0676023797418903 0.231308004962795 1.02824970367444 0.833333333333333 24.2 24 2 left-sided isomerism 0.0676023797418903 0.231308004962795 1.02824970367444 0.833333333333333 24.2 24 2 epidermal necrosis 0.0676023797418903 0.231308004962795 1.02824970367444 0.833333333333333 24.2 24 2 absent ectoplacental cone 0.0676023797418903 0.231308004962795 1.02824970367444 0.833333333333333 24.2 24 2 delayed brain development 0.0676023797418903 0.231308004962795 1.02824970367444 0.833333333333333 24.2 24 2 reduced NMDA-mediated synaptic currents 0.0676023797418903 0.231308004962795 1.02824970367444 0.833333333333333 24.2 24 2 abnormal gustatory system physiology 0.0676023797418903 0.231308004962795 1.02824970367444 0.833333333333333 24.2 24 2 abnormal lymph node cortex morphology 0.0676023797418903 0.231308004962795 1.02824970367444 0.833333333333333 24.2 24 2 chromatolysis 0.0676023797418903 0.231308004962795 1.02824970367444 0.833333333333333 24.2 24 2 increased post-tetanic potentiation 0.0676023797418903 0.231308004962795 1.02824970367444 0.833333333333333 24.2 24 2 ectopic thymus 0.0676023797418903 0.231308004962795 1.02824970367444 0.833333333333333 24.2 24 2 phenotypic reversion 0.0676023797418903 0.231308004962795 1.02824970367444 0.833333333333333 24.2 24 2 extremity edema 0.0676023797418903 0.231308004962795 1.02824970367444 0.833333333333333 24.2 24 2 bile duct inflammation 0.0676023797418903 0.231308004962795 1.02824970367444 0.833333333333333 24.2 24 2 abnormal intestinal peristalsis 0.0676023797418903 0.231308004962795 1.02824970367444 0.833333333333333 24.2 24 2 decreased heart right ventricle size 0.0676023797418903 0.231308004962795 1.02824970367444 0.833333333333333 24.2 24 2 abnormal lambdoidal suture morphology 0.0676023797418903 0.231308004962795 1.02824970367444 0.833333333333333 24.2 24 2 matted coat 0.0676023797418903 0.231308004962795 1.02824970367444 0.833333333333333 24.2 24 2 abnormal cholesterol level 0.0676023797418903 0.231308004962795 1.02824970367444 0.833333333333333 24.2 24 2 abnormal physical strength 0.0676023797418903 0.231308004962795 1.02824970367444 0.833333333333333 24.2 24 2 absent incus 0.0676023797418903 0.231308004962795 1.02824970367444 0.833333333333333 24.2 24 2 vestibular saccular degeneration 0.0676023797418903 0.231308004962795 1.02824970367444 0.833333333333333 24.2 24 2 absent parietal bone 0.0676023797418903 0.231308004962795 1.02824970367444 0.833333333333333 24.2 24 2 abnormal heart size 0.0676023797418903 0.231308004962795 1.02824970367444 0.833333333333333 24.2 24 2 decreased platelet ADP level 0.0676023797418903 0.231308004962795 1.02824970367444 0.833333333333333 24.2 24 2 abnormal eyelid development 0.0676023797418903 0.231308004962795 1.02824970367444 0.833333333333333 24.2 24 2 delayed chorioallantoic fusion 0.0676023797418903 0.231308004962795 1.02824970367444 0.833333333333333 24.2 24 2 abnormal thromboxane level 0.0676023797418903 0.231308004962795 1.02824970367444 0.833333333333333 24.2 24 2 increased transitional stage T1 B cell number 0.0676023797418903 0.231308004962795 1.02824970367444 0.833333333333333 24.2 24 2 increased erythrocyte clearance 0.0676023797418903 0.231308004962795 1.02824970367444 0.833333333333333 24.2 24 2 decreased DN1 thymic pro-T cell number 0.0676023797418903 0.231308004962795 1.02824970367444 0.833333333333333 24.2 24 2 enlarged lymphatic vessel 0.0676023797418903 0.231308004962795 1.02824970367444 0.833333333333333 24.2 24 2 myocardium hypoplasia 0.0676023797418903 0.231308004962795 1.02824970367444 0.833333333333333 24.2 24 2 cerebral arteriovenous malformation 0.0676023797418903 0.231308004962795 1.02824970367444 0.833333333333333 24.2 24 2 absent third pharyngeal arch 0.0676023797418903 0.231308004962795 1.02824970367444 0.833333333333333 24.2 24 2 increased macrophage apoptosis 0.0676023797418903 0.231308004962795 1.02824970367444 0.833333333333333 24.2 24 2 abnormal ureteric bud tip morphology 0.0676023797418903 0.231308004962795 1.02824970367444 0.833333333333333 24.2 24 2 abnormal endocrine pancreas development 0.0676023797418903 0.231308004962795 1.02824970367444 0.833333333333333 24.2 24 2 delayed limb development 0.0676023797418903 0.231308004962795 1.02824970367444 0.833333333333333 24.2 24 2 increased CD11b-high dendritic cell number 0.0676023797418903 0.231308004962795 1.02824970367444 0.833333333333333 24.2 24 2 increased effector memory T-helper cell number 0.0676023797418903 0.231308004962795 1.02824970367444 0.833333333333333 24.2 24 2 abnormal vertebral artery origin 0.0676023797418903 0.231308004962795 1.02824970367444 0.833333333333333 24.2 24 2 abnormal Wolffian duct connection 0.0676023797418903 0.231308004962795 1.02824970367444 0.833333333333333 24.2 24 2 ectopic bone 0.0676023797418903 0.231308004962795 1.02824970367444 0.833333333333333 24.2 24 2 decreased capillary density 0.0676023797418903 0.231308004962795 1.02824970367444 0.833333333333333 24.2 24 2 decreased retinal apoptosis 0.0676023797418903 0.231308004962795 1.02824970367444 0.833333333333333 24.2 24 2 abnormal cell differentiation 5.58848175913233e-07 1.24083337572552e-05 1.02323385146139 0.829268292682927 24.2 24 2 decreased circulating LDL cholesterol level 3.95209557833991e-10 1.5604504366858e-08 1.02182314302647 0.828125 24.2 24 2 abnormal definitive hematopoiesis 4.20583438945155e-14 3.37484291734217e-12 1.02161583461847 0.827956989247312 24.2 24 2 thrombocytopenia 3.61216364720124e-21 6.65574597956525e-19 1.02115832640772 0.827586206896552 24.2 24 2 abnormal embryonic erythropoiesis 3.0102584866968e-05 0.000429112778547753 1.02115832640772 0.827586206896552 24.2 24 2 polychromatophilia 3.0102584866968e-05 0.000429112778547753 1.02115832640772 0.827586206896552 24.2 24 2 abnormal cell death 1.44131179014942e-07 3.77396113473336e-06 1.01930840190335 0.826086956521739 24.2 24 2 abnormal lymphocyte physiology 1.44131179014942e-07 3.77396113473336e-06 1.01930840190335 0.826086956521739 24.2 24 2 decreased susceptibility to induced arthritis 5.22444269289718e-09 1.73277349314423e-07 1.01742602258313 0.824561403508772 24.2 24 2 embryonic lethality before implantation, complete penetrance 4.23696659048597e-18 5.85525244101881e-16 1.01673330699328 0.824 24.2 24 2 decreased mean corpuscular hemoglobin 1.92349756938078e-10 7.84377082595853e-09 1.01615264833709 0.823529411764706 24.2 24 2 increased lung adenocarcinoma incidence 3.72936985031227e-08 1.09138911795903e-06 1.01615264833709 0.823529411764706 24.2 24 2 abnormal adipose tissue morphology 0.00174942643980669 0.0133692727158806 1.01615264833709 0.823529411764706 24.2 24 2 abnormal bone marrow cavity morphology 0.00174942643980669 0.0133692727158806 1.01615264833709 0.823529411764706 24.2 24 2 abnormal circulating chemokine level 0.00174942643980669 0.0133692727158806 1.01615264833709 0.823529411764706 24.2 24 2 abnormal placenta morphology 7.15600849098812e-12 3.74748865712272e-10 1.01523388464058 0.822784810126582 24.2 24 2 decreased cell proliferation 8.97346872605143e-26 2.79018793200662e-23 1.01379862675793 0.821621621621622 24.2 24 2 lymphoid hyperplasia 5.60988215931803e-05 0.000740296120493559 1.01356042219337 0.821428571428571 24.2 24 2 increased embryonic tissue cell apoptosis 1.32185993602455e-11 6.51114176408132e-10 1.01243047746406 0.82051282051282 24.2 24 2 impaired macrophage chemotaxis 1.93267882201477e-06 3.77061848608764e-05 1.01243047746406 0.82051282051282 24.2 24 2 embryonic lethality between implantation and somite formation, complete penetrance 1.88563671307207e-33 7.81753553961128e-31 1.01230134092357 0.820408163265306 24.2 24 2 decreased lymphocyte cell number 3.83044615725454e-18 5.44470560924038e-16 1.01218330205452 0.8203125 24.2 24 2 decreased brown adipose tissue amount 1.40815679771445e-05 0.000216891023796576 1.00955425451672 0.818181818181818 24.2 24 2 decreased blood urea nitrogen level 4.94577489325297e-07 1.11841954972425e-05 1.00955425451672 0.818181818181818 24.2 24 2 abnormal mesenteric lymph node morphology 0.000421638548621142 0.00410499369743675 1.00955425451672 0.818181818181818 24.2 24 2 increased mammary gland tumor incidence 0.000421638548621142 0.00410499369743675 1.00955425451672 0.818181818181818 24.2 24 2 embryonic lethality before implantation, incomplete penetrance 0.000421638548621142 0.00410499369743675 1.00955425451672 0.818181818181818 24.2 24 2 abnormal thrombopoiesis 0.0142074083959174 0.0738192894313789 1.00955425451672 0.818181818181818 24.2 24 2 delayed hepatic development 0.0142074083959174 0.0738192894313789 1.00955425451672 0.818181818181818 24.2 24 2 abnormal eye distance/ position 0.0142074083959174 0.0738192894313789 1.00955425451672 0.818181818181818 24.2 24 2 impaired myelopoiesis 0.0142074083959174 0.0738192894313789 1.00955425451672 0.818181818181818 24.2 24 2 abnormal proximal-distal axis patterning 0.0142074083959174 0.0738192894313789 1.00955425451672 0.818181818181818 24.2 24 2 abnormal dorsal-ventral polarity of the somites 0.0142074083959174 0.0738192894313789 1.00955425451672 0.818181818181818 24.2 24 2 abnormal platelet aggregation 0.0142074083959174 0.0738192894313789 1.00955425451672 0.818181818181818 24.2 24 2 common atrioventricular valve 0.0142074083959174 0.0738192894313789 1.00955425451672 0.818181818181818 24.2 24 2 decreased embryonic cilium length 0.0142074083959174 0.0738192894313789 1.00955425451672 0.818181818181818 24.2 24 2 hypolactation 0.0142074083959174 0.0738192894313789 1.00955425451672 0.818181818181818 24.2 24 2 decreased embryo size 3.26913128087214e-63 3.25278562446778e-60 1.00931958360679 0.817991631799163 24.2 24 2 incomplete somite formation 3.56707691020032e-06 6.64651971095377e-05 1.00660234149182 0.815789473684211 24.2 24 2 embryonic lethality, complete penetrance 7.22211607985065e-42 5.13286107103671e-39 1.00568623055305 0.815047021943574 24.2 24 2 abnormal apoptosis 3.28249039563327e-08 9.72047007040208e-07 1.00539971025945 0.814814814814815 24.2 24 2 abnormal trigeminal ganglion morphology 0.000103831407514839 0.00125684003013704 1.00539971025945 0.814814814814815 24.2 24 2 decreased circulating fructosamine level 0.000103831407514839 0.00125684003013704 1.00539971025945 0.814814814814815 24.2 24 2 increased T cell proliferation 7.98479193864288e-15 6.84902411978419e-13 1.00326419685618 0.813084112149533 24.2 24 2 overriding aortic valve 2.33350520458546e-07 5.69077862392778e-06 1.00254346108258 0.8125 24.2 24 2 bradykinesia 2.59407165645318e-05 0.000378460600904826 1.00254346108258 0.8125 24.2 24 2 failure of tooth eruption 0.00325810311940347 0.0223265330840665 1.00254346108258 0.8125 24.2 24 2 abnormal bone marrow cell number 0.00325810311940347 0.0223265330840665 1.00254346108258 0.8125 24.2 24 2 intraventricular hemorrhage 0.00325810311940347 0.0223265330840665 1.00254346108258 0.8125 24.2 24 2 increased intestinal adenocarcinoma incidence 0.00325810311940347 0.0223265330840665 1.00254346108258 0.8125 24.2 24 2 abnormal amnion morphology 0.00325810311940347 0.0223265330840665 1.00254346108258 0.8125 24.2 24 2 decreased fibroblast apoptosis 0.00325810311940347 0.0223265330840665 1.00254346108258 0.8125 24.2 24 2 pallor 3.90733452469605e-23 8.83590420925583e-21 1.00122142574928 0.811428571428571 24.2 24 2 oxidative stress 1.46894489150882e-12 8.30454640370043e-11 1.00082971157645 0.811111111111111 24.2 24 2 increased erythroid progenitor cell number 6.54814333187781e-06 0.000110806166925483 1.0004591711427 0.810810810810811 24.2 24 2 abnormal chromosome morphology 6.54814333187781e-06 0.000110806166925483 1.0004591711427 0.810810810810811 24.2 24 2 increased monocyte cell number 1.01103716969338e-13 6.98598599892299e-12 0.999458711971553 0.81 24.2 24 2 abnormal eye pigmentation 0.000778827617988834 0.00691904892766866 0.99887114071231 0.80952380952381 24.2 24 2 left pulmonary isomerism 0.000778827617988834 0.00691904892766866 0.99887114071231 0.80952380952381 24.2 24 2 abnormal erythrocyte physiology 0.000778827617988834 0.00691904892766866 0.99887114071231 0.80952380952381 24.2 24 2 vascular ring 0.000778827617988834 0.00691904892766866 0.99887114071231 0.80952380952381 24.2 24 2 embryonic lethality at implantation, complete penetrance 0.000778827617988834 0.00691904892766866 0.99887114071231 0.80952380952381 24.2 24 2 embryonic lethality during organogenesis, complete penetrance 3.69043960719247e-70 6.11997901526084e-67 0.998136676638257 0.808928571428571 24.2 24 2 pericardial edema 1.04674847820411e-09 3.91546893162817e-08 0.998007065331071 0.808823529411765 24.2 24 2 abnormal vitelline vasculature morphology 1.83483153107554e-15 1.69332837783789e-13 0.997849277652758 0.808695652173913 24.2 24 2 abnormal cell nucleus morphology 4.26284992904274e-07 9.77312368524777e-06 0.9976209890969 0.808510638297872 24.2 24 2 preweaning lethality, complete penetrance 3.75082039979786e-92 1.86603314889944e-88 0.997124307238886 0.808108108108108 24.2 24 2 increased thymocyte apoptosis 0.000190766021159078 0.0021184396322911 0.996611251253685 0.807692307692308 24.2 24 2 osteopetrosis 4.74807429109489e-05 0.000636702684587522 0.995080358394617 0.806451612903226 24.2 24 2 abnormal pharyngeal arch morphology 1.19520900141558e-05 0.000189368305160589 0.993974713551956 0.805555555555556 24.2 24 2 abnormal trophoblast giant cell morphology 1.19520900141558e-05 0.000189368305160589 0.993974713551956 0.805555555555556 24.2 24 2 arrested B cell differentiation 3.03395219895498e-06 5.69581592067962e-05 0.993138738183115 0.804878048780488 24.2 24 2 failure of chorioallantoic fusion 1.990349643431e-07 5.10411828663362e-06 0.991958537662398 0.803921568627451 24.2 24 2 decreased hemoglobin content 6.52340176776488e-18 8.77133075530547e-16 0.988869927789033 0.801418439716312 24.2 24 2 decreased B cell number 1.92116706860657e-25 5.62223892136336e-23 0.988317676347274 0.800970873786408 24.2 24 2 liver hemorrhage 8.63116972577193e-05 0.00107619221518084 0.98711971552746 0.8 24.2 24 2 abnormal primitive streak morphology 0.00034770893039827 0.00348760469502297 0.98711971552746 0.8 24.2 24 2 absent incisors 0.00599728986594763 0.0367897867855604 0.98711971552746 0.8 24.2 24 2 abnormal placenta size 0.00599728986594763 0.0367897867855604 0.98711971552746 0.8 24.2 24 2 absent chorion 0.00599728986594763 0.0367897867855604 0.98711971552746 0.8 24.2 24 2 abnormal liver development 2.16842802215673e-05 0.000320116599710081 0.987119715527459 0.8 24.2 24 2 abnormal dermal layer morphology 2.16842802215673e-05 0.000320116599710081 0.987119715527459 0.8 24.2 24 2 abnormal hippocampus pyramidal cell morphology 2.16842802215673e-05 0.000320116599710081 0.987119715527459 0.8 24.2 24 2 abnormal myocardial trabeculae morphology 1.40254760049654e-06 2.80227884034951e-05 0.987119715527459 0.8 24.2 24 2 small gonad 0.00142504752984223 0.0113615568284697 0.987119715527459 0.8 24.2 24 2 anencephaly 0.00142504752984223 0.0113615568284697 0.987119715527459 0.8 24.2 24 2 abnormal physiological neovascularization 0.00142504752984223 0.0113615568284697 0.987119715527459 0.8 24.2 24 2 abnormal optic stalk morphology 0.00142504752984223 0.0113615568284697 0.987119715527459 0.8 24.2 24 2 abnormal neuron proliferation 0.00142504752984223 0.0113615568284697 0.987119715527459 0.8 24.2 24 2 abnormal auchene hair morphology 0.02643062600453 0.115445447210304 0.987119715527459 0.8 24.2 24 2 increased cranium width 0.02643062600453 0.115445447210304 0.987119715527459 0.8 24.2 24 2 rhinitis 0.02643062600453 0.115445447210304 0.987119715527459 0.8 24.2 24 2 abnormal mammary gland physiology 0.02643062600453 0.115445447210304 0.987119715527459 0.8 24.2 24 2 abnormal tibialis anterior morphology 0.02643062600453 0.115445447210304 0.987119715527459 0.8 24.2 24 2 peritoneal inflammation 0.02643062600453 0.115445447210304 0.987119715527459 0.8 24.2 24 2 bifid ureter 0.02643062600453 0.115445447210304 0.987119715527459 0.8 24.2 24 2 abnormal pillar cell morphology 0.02643062600453 0.115445447210304 0.987119715527459 0.8 24.2 24 2 abnormal embryonic erythrocyte morphology 0.02643062600453 0.115445447210304 0.987119715527459 0.8 24.2 24 2 abnormal deltoid tuberosity morphology 0.02643062600453 0.115445447210304 0.987119715527459 0.8 24.2 24 2 abnormal corneal endothelium morphology 0.02643062600453 0.115445447210304 0.987119715527459 0.8 24.2 24 2 increased susceptibility to atherosclerosis 0.02643062600453 0.115445447210304 0.987119715527459 0.8 24.2 24 2 protruding tongue 0.02643062600453 0.115445447210304 0.987119715527459 0.8 24.2 24 2 abnormal hippocampus neuron morphology 0.02643062600453 0.115445447210304 0.987119715527459 0.8 24.2 24 2 abnormal cerebellar granule cell migration 0.02643062600453 0.115445447210304 0.987119715527459 0.8 24.2 24 2 aorta stenosis 0.02643062600453 0.115445447210304 0.987119715527459 0.8 24.2 24 2 thick aortic valve cusps 0.02643062600453 0.115445447210304 0.987119715527459 0.8 24.2 24 2 abnormal adaptive thermogenesis 0.02643062600453 0.115445447210304 0.987119715527459 0.8 24.2 24 2 decreased macrophage cytokine production 0.02643062600453 0.115445447210304 0.987119715527459 0.8 24.2 24 2 decreased macrophage apoptosis 0.02643062600453 0.115445447210304 0.987119715527459 0.8 24.2 24 2 increased fatty acid oxidation 0.02643062600453 0.115445447210304 0.987119715527459 0.8 24.2 24 2 enlarged spleen 1.55678258703015e-34 7.04090306406816e-32 0.985405966021336 0.798611111111111 24.2 24 2 increased tumor incidence 1.15745450816762e-15 1.17517064859875e-13 0.98512955481067 0.798387096774194 24.2 24 2 decreased platelet aggregation 1.66750052673345e-07 4.32073704192651e-06 0.982549716844462 0.796296296296296 24.2 24 2 anemia 2.49438588590021e-25 6.89420543464085e-23 0.982441423036808 0.796208530805687 24.2 24 2 muscular atrophy 2.52494032784957e-06 4.79449546986702e-05 0.981511080780144 0.795454545454545 24.2 24 2 abnormal leukocyte adhesion 9.90036950191926e-06 0.000160471299764075 0.980792025043309 0.794871794871795 24.2 24 2 increased hepatocyte apoptosis 9.90036950191926e-06 0.000160471299764075 0.980792025043309 0.794871794871795 24.2 24 2 lethality throughout fetal growth and development, complete penetrance 9.24323424188176e-23 1.83940361413447e-20 0.980625506872673 0.794736842105263 24.2 24 2 abnormal embryonic neuroepithelium morphology 7.71885297679281e-08 2.1216184287041e-06 0.978610062807395 0.793103448275862 24.2 24 2 lordosis 0.000155751062376994 0.00176104894392169 0.978610062807395 0.793103448275862 24.2 24 2 abnormal inflammatory response 2.41784465876021e-09 8.71650520096526e-08 0.976837218490715 0.791666666666667 24.2 24 2 hydrops fetalis 2.41784465876021e-09 8.71650520096526e-08 0.976837218490715 0.791666666666667 24.2 24 2 decreased body height 0.000628329102102593 0.00582111225877169 0.976837218490715 0.791666666666667 24.2 24 2 ocular hypertelorism 0.000628329102102593 0.00582111225877169 0.976837218490715 0.791666666666667 24.2 24 2 hemolytic anemia 0.000628329102102593 0.00582111225877169 0.976837218490715 0.791666666666667 24.2 24 2 abnormal cellular extravasation 0.000628329102102593 0.00582111225877169 0.976837218490715 0.791666666666667 24.2 24 2 impaired macrophage phagocytosis 4.52127638923848e-06 8.00475090265532e-05 0.975641579300396 0.790697674418605 24.2 24 2 abnormal double-strand DNA break repair 4.52127638923848e-06 8.00475090265532e-05 0.975641579300396 0.790697674418605 24.2 24 2 increased eosinophil cell number 3.57017338308156e-08 1.05098299294856e-06 0.975178751226724 0.790322580645161 24.2 24 2 altered susceptibility to infection 0.00258038019830061 0.0182090659383625 0.974131298217888 0.789473684210526 24.2 24 2 abnormal digestive system development 0.00258038019830061 0.0182090659383625 0.974131298217888 0.789473684210526 24.2 24 2 oliguria 0.00258038019830061 0.0182090659383625 0.974131298217888 0.789473684210526 24.2 24 2 increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 0.00258038019830061 0.0182090659383625 0.974131298217888 0.789473684210526 24.2 24 2 shortened RR interval 0.00258038019830061 0.0182090659383625 0.974131298217888 0.789473684210526 24.2 24 2 abnormal leukocyte migration 5.32346042065755e-07 1.19298268435907e-05 0.972882411938121 0.788461538461538 24.2 24 2 abnormal vascular development 1.6503720374877e-08 5.00646395518374e-07 0.972163356201286 0.787878787878788 24.2 24 2 abnormal aorta morphology 6.99889827462554e-05 0.000895103314042727 0.972163356201286 0.787878787878788 24.2 24 2 cardiovascular system phenotype 6.99889827462554e-05 0.000895103314042727 0.972163356201286 0.787878787878788 24.2 24 2 myeloid hyperplasia 6.99889827462554e-05 0.000895103314042727 0.972163356201286 0.787878787878788 24.2 24 2 abnormal NK cell physiology 6.34417946266579e-08 1.75346071259791e-06 0.970937425108977 0.786885245901639 24.2 24 2 abnormal embryo development 5.66024238667359e-16 5.99142678163853e-14 0.970788690822042 0.786764705882353 24.2 24 2 embryonic growth arrest 8.4885969384292e-26 2.79018793200662e-23 0.969877449754054 0.786026200873362 24.2 24 2 abnormal somite shape 0.000278850889227586 0.00287818085872871 0.969492577750183 0.785714285714286 24.2 24 2 straub tail 0.000278850889227586 0.00287818085872871 0.969492577750183 0.785714285714286 24.2 24 2 failure of blastocyst to hatch from the zona pellucida 0.000278850889227586 0.00287818085872871 0.969492577750183 0.785714285714286 24.2 24 2 premature aging 0.000278850889227586 0.00287818085872871 0.969492577750183 0.785714285714286 24.2 24 2 abnormal brainstem morphology 0.000278850889227586 0.00287818085872871 0.969492577750183 0.785714285714286 24.2 24 2 increased triglyceride level 0.000278850889227586 0.00287818085872871 0.969492577750183 0.785714285714286 24.2 24 2 abnormal kidney blood vessel morphology 0.0108939268814898 0.0590384381649366 0.969492577750183 0.785714285714286 24.2 24 2 translucent skin 0.0108939268814898 0.0590384381649366 0.969492577750183 0.785714285714286 24.2 24 2 absent visceral yolk sac blood islands 0.0108939268814898 0.0590384381649366 0.969492577750183 0.785714285714286 24.2 24 2 abnormal antigen presentation 0.0108939268814898 0.0590384381649366 0.969492577750183 0.785714285714286 24.2 24 2 absent otoliths 0.0108939268814898 0.0590384381649366 0.969492577750183 0.785714285714286 24.2 24 2 abnormal ventral body wall morphology 0.0108939268814898 0.0590384381649366 0.969492577750183 0.785714285714286 24.2 24 2 failure of zygotic cell division 0.0108939268814898 0.0590384381649366 0.969492577750183 0.785714285714286 24.2 24 2 abnormal maternal decidual layer morphology 0.0108939268814898 0.0590384381649366 0.969492577750183 0.785714285714286 24.2 24 2 split sternum 0.0108939268814898 0.0590384381649366 0.969492577750183 0.785714285714286 24.2 24 2 increased B-1 B cell number 0.0108939268814898 0.0590384381649366 0.969492577750183 0.785714285714286 24.2 24 2 testis degeneration 0.0108939268814898 0.0590384381649366 0.969492577750183 0.785714285714286 24.2 24 2 abnormal spleen white pulp morphology 8.05068312466295e-06 0.000135311312652697 0.969492577750183 0.785714285714286 24.2 24 2 abnormal placenta labyrinth morphology 9.22592721313646e-10 3.47719605192075e-08 0.96837693611871 0.784810126582278 24.2 24 2 abnormal hepatocyte morphology 4.4177456825245e-13 2.64798611693486e-11 0.967110532104606 0.783783783783784 24.2 24 2 increased erythrocyte cell number 1.12267334329262e-07 3.00284939939827e-06 0.966554721453971 0.783333333333333 24.2 24 2 failure to gastrulate 3.6612971195073e-06 6.77135805559435e-05 0.965660591276863 0.782608695652174 24.2 24 2 abnormal allantois morphology 3.6612971195073e-06 6.77135805559435e-05 0.965660591276863 0.782608695652174 24.2 24 2 failure of embryo implantation 0.00112484438810699 0.00926506760071569 0.965660591276863 0.782608695652174 24.2 24 2 abnormal Wolffian duct morphology 0.00112484438810699 0.00926506760071569 0.965660591276863 0.782608695652174 24.2 24 2 abnormal chondrocyte physiology 0.00112484438810699 0.00926506760071569 0.965660591276863 0.782608695652174 24.2 24 2 abnormal embryonic tissue morphology 1.01292238071637e-16 1.19983067715808e-14 0.965295640184165 0.782312925170068 24.2 24 2 lethality throughout fetal growth and development, incomplete penetrance 5.04340720958939e-20 8.65205202334731e-18 0.965061174398354 0.782122905027933 24.2 24 2 abnormal embryo turning 4.32089830207565e-07 9.81573929352801e-06 0.964685176538199 0.781818181818182 24.2 24 2 abnormal T-helper 2 physiology 4.32089830207565e-07 9.81573929352801e-06 0.964685176538199 0.781818181818182 24.2 24 2 abnormal osteoclast physiology 5.15758459981331e-08 1.47465421747536e-06 0.963984097194785 0.78125 24.2 24 2 abnormal spongiotrophoblast layer morphology 0.000124409408433866 0.0014701586863622 0.963984097194785 0.78125 24.2 24 2 pancreatic islet hyperplasia 0.000124409408433866 0.0014701586863622 0.963984097194785 0.78125 24.2 24 2 increased grip strength 9.14140710434285e-11 3.95465220383528e-09 0.962712909374308 0.78021978021978 24.2 24 2 abnormal liver physiology 1.11594881543128e-11 5.60792460279863e-10 0.962441722639273 0.78 24.2 24 2 decreased double-positive T cell number 1.11594881543128e-11 5.60792460279863e-10 0.962441722639273 0.78 24.2 24 2 increased leukocyte cell number 3.12285566278494e-16 3.45249042719002e-14 0.961590757367267 0.779310344827586 24.2 24 2 abnormal embryo size 6.33354187984458e-13 3.66388033165427e-11 0.960912997416111 0.778761061946903 24.2 24 2 increased spleen weight 6.33354187984458e-13 3.66388033165427e-11 0.960912997416111 0.778761061946903 24.2 24 2 abnormal mitral valve morphology 0.00461866856836327 0.0291297675282955 0.959699723429475 0.777777777777778 24.2 24 2 underdeveloped hair follicles 0.00461866856836327 0.0291297675282955 0.959699723429475 0.777777777777778 24.2 24 2 abnormal thymus cortex morphology 0.00461866856836327 0.0291297675282955 0.959699723429475 0.777777777777778 24.2 24 2 abnormal redox activity 0.00461866856836327 0.0291297675282955 0.959699723429475 0.777777777777778 24.2 24 2 darkened coat color 0.00461866856836327 0.0291297675282955 0.959699723429475 0.777777777777778 24.2 24 2 decreased lactate dehydrogenase level 0.00461866856836327 0.0291297675282955 0.959699723429475 0.777777777777778 24.2 24 2 increased gastrointestinal tumor incidence 0.00461866856836327 0.0291297675282955 0.959699723429475 0.777777777777778 24.2 24 2 decreased tumor latency 0.00461866856836327 0.0291297675282955 0.959699723429475 0.777777777777778 24.2 24 2 distorted hair follicle pattern 0.0482786108245305 0.178577017733858 0.959699723429475 0.777777777777778 24.2 24 2 thick tail 0.0482786108245305 0.178577017733858 0.959699723429475 0.777777777777778 24.2 24 2 abnormal kindling response 0.0482786108245305 0.178577017733858 0.959699723429475 0.777777777777778 24.2 24 2 decreased level of surface class I molecules 0.0482786108245305 0.178577017733858 0.959699723429475 0.777777777777778 24.2 24 2 increased pheochromocytoma incidence 0.0482786108245305 0.178577017733858 0.959699723429475 0.777777777777778 24.2 24 2 abnormal germ cell morphology 0.0482786108245305 0.178577017733858 0.959699723429475 0.777777777777778 24.2 24 2 abnormal posterior semicircular canal morphology 0.0482786108245305 0.178577017733858 0.959699723429475 0.777777777777778 24.2 24 2 enlarged otoliths 0.0482786108245305 0.178577017733858 0.959699723429475 0.777777777777778 24.2 24 2 priapism 0.0482786108245305 0.178577017733858 0.959699723429475 0.777777777777778 24.2 24 2 abnormal posterior eye segment morphology 0.0482786108245305 0.178577017733858 0.959699723429475 0.777777777777778 24.2 24 2 positive geotaxis 0.0482786108245305 0.178577017733858 0.959699723429475 0.777777777777778 24.2 24 2 abnormal leukopoiesis 0.0482786108245305 0.178577017733858 0.959699723429475 0.777777777777778 24.2 24 2 abnormal liver vasculature morphology 0.0482786108245305 0.178577017733858 0.959699723429475 0.777777777777778 24.2 24 2 abnormal cerebellar layer morphology 0.0482786108245305 0.178577017733858 0.959699723429475 0.777777777777778 24.2 24 2 axonal spheroids 0.0482786108245305 0.178577017733858 0.959699723429475 0.777777777777778 24.2 24 2 abnormal telomere morphology 0.0482786108245305 0.178577017733858 0.959699723429475 0.777777777777778 24.2 24 2 prolonged RR interval 0.0482786108245305 0.178577017733858 0.959699723429475 0.777777777777778 24.2 24 2 shortened ST segment 0.0482786108245305 0.178577017733858 0.959699723429475 0.777777777777778 24.2 24 2 decreased susceptibility to parasitic infection induced morbidity/mortality 0.0482786108245305 0.178577017733858 0.959699723429475 0.777777777777778 24.2 24 2 abnormal heart left ventricle pressure 0.0482786108245305 0.178577017733858 0.959699723429475 0.777777777777778 24.2 24 2 increased core body temperature 0.0482786108245305 0.178577017733858 0.959699723429475 0.777777777777778 24.2 24 2 abnormal ductus venosus valve topology 0.0482786108245305 0.178577017733858 0.959699723429475 0.777777777777778 24.2 24 2 abnormal infrahyoid muscle connection 0.0482786108245305 0.178577017733858 0.959699723429475 0.777777777777778 24.2 24 2 abnormal coronary sinus connection 0.0482786108245305 0.178577017733858 0.959699723429475 0.777777777777778 24.2 24 2 increased cardiac muscle glycogen level 0.0482786108245305 0.178577017733858 0.959699723429475 0.777777777777778 24.2 24 2 decreased fatty acid oxidation 0.0482786108245305 0.178577017733858 0.959699723429475 0.777777777777778 24.2 24 2 cerebellum atrophy 0.0482786108245305 0.178577017733858 0.959699723429475 0.777777777777778 24.2 24 2 decreased neutrophil cell number 2.93562527479823e-13 1.84870072685078e-11 0.959699723429475 0.777777777777778 24.2 24 2 abnormal eye muscle morphology 0.000495037168913915 0.00469106650542234 0.959699723429475 0.777777777777778 24.2 24 2 thrombocytosis 3.46993818575861e-07 8.10466782823901e-06 0.957335931007234 0.775862068965517 24.2 24 2 increased sarcoma incidence 2.92808337683828e-06 5.51788439385243e-05 0.956901765052129 0.775510204081633 24.2 24 2 pale kidney 0.000219446397875218 0.00237853121880003 0.955277144058832 0.774193548387097 24.2 24 2 decreased leukocyte cell number 6.26258449825225e-15 5.46602769803596e-13 0.954696075236412 0.773722627737226 24.2 24 2 abnormal mesoderm development 1.33089071202578e-06 2.68064019932318e-05 0.954526140014761 0.773584905660377 24.2 24 2 decreased macrophage cell number 1.13088189979608e-05 0.000181488304886628 0.953467907043569 0.772727272727273 24.2 24 2 intracerebral hemorrhage 0.00199327045383898 0.0148896704322056 0.953467907043569 0.772727272727273 24.2 24 2 abnormal oogenesis 0.00199327045383898 0.0148896704322056 0.953467907043569 0.772727272727273 24.2 24 2 abnormal vascular branching morphogenesis 0.00199327045383898 0.0148896704322056 0.953467907043569 0.772727272727273 24.2 24 2 abnormal female reproductive system physiology 0.00199327045383898 0.0148896704322056 0.953467907043569 0.772727272727273 24.2 24 2 decreased susceptibility to viral infection induced morbidity/mortality 0.00199327045383898 0.0148896704322056 0.953467907043569 0.772727272727273 24.2 24 2 abnormal cerebral cortex pyramidal cell morphology 0.00199327045383898 0.0148896704322056 0.953467907043569 0.772727272727273 24.2 24 2 abnormal nervous system morphology 4.01517750298769e-09 1.35887810050094e-07 0.952757953278086 0.772151898734177 24.2 24 2 abnormal response to infection 4.01517750298769e-09 1.35887810050094e-07 0.952757953278086 0.772151898734177 24.2 24 2 absent vitelline blood vessels 6.05858954463921e-07 1.3336939373708e-05 0.952483936035268 0.771929824561403 24.2 24 2 increased carcinoma incidence 9.78337411877519e-05 0.00119587926881834 0.951865439972907 0.771428571428571 24.2 24 2 increased circulating serum albumin level 9.78337411877519e-05 0.00119587926881834 0.951865439972907 0.771428571428571 24.2 24 2 decreased bone volume 9.78337411877519e-05 0.00119587926881834 0.951865439972907 0.771428571428571 24.2 24 2 small heart 5.11446265250435e-06 8.77394886076177e-05 0.951130975898854 0.770833333333333 24.2 24 2 prenatal lethality, complete penetrance 4.04410733546607e-28 1.43710242813884e-25 0.949836416919408 0.76978417266187 24.2 24 2 abnormal placenta vasculature 2.31818422118142e-06 4.47014205440991e-05 0.949153572622557 0.769230769230769 24.2 24 2 abnormal leukocyte cell number 0.000870851961195571 0.00757428060655239 0.949153572622557 0.769230769230769 24.2 24 2 ventricular hypoplasia 0.000870851961195571 0.00757428060655239 0.949153572622557 0.769230769230769 24.2 24 2 abnormal erythrocyte osmotic lysis 0.000870851961195571 0.00757428060655239 0.949153572622557 0.769230769230769 24.2 24 2 abnormal Mullerian duct morphology 0.000870851961195571 0.00757428060655239 0.949153572622557 0.769230769230769 24.2 24 2 pulmonary edema 0.000870851961195571 0.00757428060655239 0.949153572622557 0.769230769230769 24.2 24 2 absent teeth 0.0194906518474482 0.0901170938113893 0.949153572622557 0.769230769230769 24.2 24 2 absent myocardial trabeculae 0.0194906518474482 0.0901170938113893 0.949153572622557 0.769230769230769 24.2 24 2 abnormal mast cell morphology 0.0194906518474482 0.0901170938113893 0.949153572622557 0.769230769230769 24.2 24 2 abnormal grip strength 0.0194906518474482 0.0901170938113893 0.949153572622557 0.769230769230769 24.2 24 2 abnormal digestion 0.0194906518474482 0.0901170938113893 0.949153572622557 0.769230769230769 24.2 24 2 lymphoid hypoplasia 0.0194906518474482 0.0901170938113893 0.949153572622557 0.769230769230769 24.2 24 2 abnormal pulmonary alveolus epithelial cell morphology 0.0194906518474482 0.0901170938113893 0.949153572622557 0.769230769230769 24.2 24 2 abnormal lung interstitium morphology 0.0194906518474482 0.0901170938113893 0.949153572622557 0.769230769230769 24.2 24 2 abnormal tail bud morphology 0.0194906518474482 0.0901170938113893 0.949153572622557 0.769230769230769 24.2 24 2 abnormal coping response 0.0194906518474482 0.0901170938113893 0.949153572622557 0.769230769230769 24.2 24 2 abnormal telomere length 0.0194906518474482 0.0901170938113893 0.949153572622557 0.769230769230769 24.2 24 2 small otic vesicle 0.0194906518474482 0.0901170938113893 0.949153572622557 0.769230769230769 24.2 24 2 increased circulating thyroxine level 0.0194906518474482 0.0901170938113893 0.949153572622557 0.769230769230769 24.2 24 2 decreased cardiac stroke volume 0.0194906518474482 0.0901170938113893 0.949153572622557 0.769230769230769 24.2 24 2 abnormal lipid homeostasis 7.07625347167685e-14 5.33399409418066e-12 0.949153572622557 0.769230769230769 24.2 24 2 decreased monocyte cell number 1.26051075823622e-07 3.35349787284771e-06 0.949153572622557 0.769230769230769 24.2 24 2 increased inflammatory response 1.7927952488405e-10 7.37120360576983e-09 0.948154463598744 0.768421052631579 24.2 24 2 increased lymphocyte cell number 5.75930152139552e-08 1.63728714679673e-06 0.947777987734698 0.768115942028985 24.2 24 2 increased oxygen consumption 1.46756969305541e-09 5.40826609107457e-08 0.946946238732737 0.767441860465116 24.2 24 2 abnormal homeostasis 1.96977253515639e-05 0.000294282833705797 0.946946238732737 0.767441860465116 24.2 24 2 delayed endochondral bone ossification 1.96977253515639e-05 0.000294282833705797 0.946946238732737 0.767441860465116 24.2 24 2 decreased hematocrit 3.22178971176385e-15 2.9142552392773e-13 0.946553151875646 0.767123287671233 24.2 24 2 abnormal lactation 0.000383908976340323 0.00376715415639666 0.945989727380482 0.766666666666667 24.2 24 2 abnormal spleen marginal zone morphology 0.000383908976340323 0.00376715415639666 0.945989727380482 0.766666666666667 24.2 24 2 abnormal optic cup morphology 0.000383908976340323 0.00376715415639666 0.945989727380482 0.766666666666667 24.2 24 2 abnormal dendritic cell physiology 1.74794590394868e-11 8.36156814629299e-10 0.945605334967893 0.766355140186916 24.2 24 2 decreased eosinophil cell number 2.18169707522283e-07 5.48178936829979e-06 0.944704415250889 0.765625 24.2 24 2 abnormal trophoblast layer morphology 4.01649491698409e-06 7.34634640146907e-05 0.943570316313013 0.764705882352941 24.2 24 2 abnormal interatrial septum morphology 0.00816130232809298 0.046777049633943 0.943570316313013 0.764705882352941 24.2 24 2 hyperlipidemia 0.00816130232809298 0.046777049633943 0.943570316313013 0.764705882352941 24.2 24 2 decreased vasoconstriction 0.00816130232809298 0.046777049633943 0.943570316313013 0.764705882352941 24.2 24 2 abnormal embryonic-extraembryonic boundary morphology 0.00816130232809298 0.046777049633943 0.943570316313013 0.764705882352941 24.2 24 2 increased regulatory T cell number 0.00816130232809298 0.046777049633943 0.943570316313013 0.764705882352941 24.2 24 2 abnormal ectoplacental cone morphology 0.00816130232809298 0.046777049633943 0.943570316313013 0.764705882352941 24.2 24 2 abnormal melanosome morphology 0.00816130232809298 0.046777049633943 0.943570316313013 0.764705882352941 24.2 24 2 pancytopenia 0.00816130232809298 0.046777049633943 0.943570316313013 0.764705882352941 24.2 24 2 enhanced behavioral response to cocaine 0.00816130232809298 0.046777049633943 0.943570316313013 0.764705882352941 24.2 24 2 increased circulating magnesium level 0.00816130232809298 0.046777049633943 0.943570316313013 0.764705882352941 24.2 24 2 increased hepatoma incidence 0.00816130232809298 0.046777049633943 0.943570316313013 0.764705882352941 24.2 24 2 persistence of hyaloid vascular system 7.60539940044236e-05 0.000957895240941791 0.941660254943958 0.763157894736842 24.2 24 2 decreased neuron apoptosis 7.60539940044236e-05 0.000957895240941791 0.941660254943958 0.763157894736842 24.2 24 2 decreased total retina thickness 7.60539940044236e-05 0.000957895240941791 0.941660254943958 0.763157894736842 24.2 24 2 skin edema 3.40916679954469e-05 0.0004681897503256 0.940114014788057 0.761904761904762 24.2 24 2 liver degeneration 0.00349295124777311 0.0236427652485323 0.940114014788057 0.761904761904762 24.2 24 2 increased acute inflammation 0.00349295124777311 0.0236427652485323 0.940114014788057 0.761904761904762 24.2 24 2 abnormal clavicle morphology 0.00349295124777311 0.0236427652485323 0.940114014788057 0.761904761904762 24.2 24 2 internal hemorrhage 1.71239484265992e-07 4.41407478872181e-06 0.939237042759337 0.761194029850746 24.2 24 2 thymus hypoplasia 6.09314462435511e-14 4.66359915479487e-12 0.938836685963616 0.760869565217391 24.2 24 2 abnormal myelin sheath morphology 1.53370077274695e-05 0.000234774195212802 0.938836685963616 0.760869565217391 24.2 24 2 abnormal thyroid gland morphology 0.00151695964583295 0.0118461010289941 0.937763729751087 0.76 24.2 24 2 spontaneous skin ulceration 0.00151695964583295 0.0118461010289941 0.937763729751087 0.76 24.2 24 2 abnormal preimplantation embryo development 0.00151695964583295 0.0118461010289941 0.937763729751087 0.76 24.2 24 2 abnormal neural tube closure 7.45917955571725e-09 2.44140909800614e-07 0.936574428889005 0.759036144578313 24.2 24 2 abnormal spleen morphology 5.74532507059635e-17 7.32897236569663e-15 0.936061799207074 0.758620689655172 24.2 24 2 abnormal microglial cell morphology 0.000665736059329448 0.00609951546070719 0.936061799207074 0.758620689655172 24.2 24 2 decreased granulocyte number 0.000665736059329448 0.00609951546070719 0.936061799207074 0.758620689655172 24.2 24 2 increased cardiomyocyte apoptosis 0.00029447323870765 0.00302686851770777 0.934772457885852 0.757575757575758 24.2 24 2 domed cranium 1.33664537790182e-07 3.53713338035188e-06 0.934238302195631 0.757142857142857 24.2 24 2 double outlet right ventricle 6.94341263155585e-11 3.05694494176906e-09 0.934073562590236 0.757009345794392 24.2 24 2 decreased T cell proliferation 1.73773582490604e-14 1.44087262148459e-12 0.933761893066516 0.756756756756757 24.2 24 2 decreased IgG level 3.19050391181777e-11 1.45621623498105e-09 0.933761893066516 0.756756756756757 24.2 24 2 abnormal angiogenesis 6.09804490351446e-08 1.69484767569746e-06 0.933761893066516 0.756756756756757 24.2 24 2 malocclusion 0.00013105309904558 0.00151748167185251 0.933761893066516 0.756756756756757 24.2 24 2 abnormal branching of the mammary ductal tree 0.00013105309904558 0.00151748167185251 0.933761893066516 0.756756756756757 24.2 24 2 decreased width of hypertrophic chondrocyte zone 0.00013105309904558 0.00151748167185251 0.933761893066516 0.756756756756757 24.2 24 2 abnormal calcium ion homeostasis 0.00013105309904558 0.00151748167185251 0.933761893066516 0.756756756756757 24.2 24 2 sparse hair 1.27336324938255e-08 3.91048281831988e-07 0.932948511626562 0.75609756097561 24.2 24 2 abnormal developmental patterning 1.27336324938255e-08 3.91048281831988e-07 0.932948511626562 0.75609756097561 24.2 24 2 abnormal ectoderm development 2.63167408369396e-05 0.00038170782992354 0.932279731331489 0.755555555555556 24.2 24 2 small placenta 2.63167408369396e-05 0.00038170782992354 0.932279731331489 0.755555555555556 24.2 24 2 abnormal respiratory system physiology 1.18557987524749e-05 0.000189046791005008 0.931720139656021 0.755102040816326 24.2 24 2 increased circulating bilirubin level 5.35601040319888e-06 9.1567531807266e-05 0.931245014648547 0.754716981132076 24.2 24 2 impaired natural killer cell mediated cytotoxicity 2.42540482909397e-06 4.6231375573726e-05 0.930836573852648 0.754385964912281 24.2 24 2 abnormal heart development 4.90466950882013e-15 4.35727335828217e-13 0.929329479017149 0.753164556962025 24.2 24 2 increased neutrophil cell number 8.49229709231961e-14 6.30584746780449e-12 0.927552146487009 0.751724137931034 24.2 24 2 increased sacral vertebrae number 8.49188115652963e-07 1.80543199802286e-05 0.925424733306993 0.75 24.2 24 2 absent mesoderm 1.86929884830633e-06 3.67535623280527e-05 0.925424733306993 0.75 24.2 24 2 decreased IgA level 9.11142700439216e-06 0.000149601813025911 0.925424733306993 0.75 24.2 24 2 kinked neural tube 9.11142700439216e-06 0.000149601813025911 0.925424733306993 0.75 24.2 24 2 increased fatty acid level 0.000504557366199274 0.00477219181909009 0.925424733306993 0.75 24.2 24 2 abnormal nursing 0.00261439024612021 0.0183968762014824 0.925424733306993 0.75 24.2 24 2 decreased fatty acid level 0.00261439024612021 0.0183968762014824 0.925424733306993 0.75 24.2 24 2 abnormal hair follicle orientation 0.0142148501055801 0.0738192894313789 0.925424733306993 0.75 24.2 24 2 impaired muscle relaxation 0.0142148501055801 0.0738192894313789 0.925424733306993 0.75 24.2 24 2 small pancreas 0.0142148501055801 0.0738192894313789 0.925424733306993 0.75 24.2 24 2 dystonia 0.0142148501055801 0.0738192894313789 0.925424733306993 0.75 24.2 24 2 decreased creatinine clearance 0.0142148501055801 0.0738192894313789 0.925424733306993 0.75 24.2 24 2 decreased midbrain size 0.0142148501055801 0.0738192894313789 0.925424733306993 0.75 24.2 24 2 abnormal supraoccipital bone morphology 0.0342662252262257 0.143741362647307 0.925424733306993 0.75 24.2 24 2 interstitial pneumonia 0.0342662252262257 0.143741362647307 0.925424733306993 0.75 24.2 24 2 increased papilloma incidence 0.0342662252262257 0.143741362647307 0.925424733306993 0.75 24.2 24 2 increased growth rate 0.0342662252262257 0.143741362647307 0.925424733306993 0.75 24.2 24 2 delayed somite formation 0.0342662252262257 0.143741362647307 0.925424733306993 0.75 24.2 24 2 abnormal rostral-caudal body axis extension 0.0342662252262257 0.143741362647307 0.925424733306993 0.75 24.2 24 2 hematuria 0.0342662252262257 0.143741362647307 0.925424733306993 0.75 24.2 24 2 abnormal palatine bone morphology 0.0342662252262257 0.143741362647307 0.925424733306993 0.75 24.2 24 2 hemoperitoneum 0.0342662252262257 0.143741362647307 0.925424733306993 0.75 24.2 24 2 decreased keratinocyte proliferation 0.0342662252262257 0.143741362647307 0.925424733306993 0.75 24.2 24 2 decreased mammary gland epithelial cell proliferation 0.0342662252262257 0.143741362647307 0.925424733306993 0.75 24.2 24 2 abnormal pulmonary valve cusp morphology 0.0342662252262257 0.143741362647307 0.925424733306993 0.75 24.2 24 2 prenatal growth retardation 0.0342662252262257 0.143741362647307 0.925424733306993 0.75 24.2 24 2 embryonic lethality between implantation and placentation, incomplete penetrance 0.0342662252262257 0.143741362647307 0.925424733306993 0.75 24.2 24 2 abnormal ear pigmentation 0.0862439221712749 0.270948434330732 0.925424733306993 0.75 24.2 24 2 abnormal bone marrow development 0.0862439221712749 0.270948434330732 0.925424733306993 0.75 24.2 24 2 enlarged pituitary gland 0.0862439221712749 0.270948434330732 0.925424733306993 0.75 24.2 24 2 abnormal urination 0.0862439221712749 0.270948434330732 0.925424733306993 0.75 24.2 24 2 abnormal atrial thrombosis 0.0862439221712749 0.270948434330732 0.925424733306993 0.75 24.2 24 2 abnormal hepatobiliary system morphology 0.0862439221712749 0.270948434330732 0.925424733306993 0.75 24.2 24 2 abnormal thyroid physiology 0.0862439221712749 0.270948434330732 0.925424733306993 0.75 24.2 24 2 decreased aerobic running capacity 0.0862439221712749 0.270948434330732 0.925424733306993 0.75 24.2 24 2 abnormal muscle precursor cell migration 0.0862439221712749 0.270948434330732 0.925424733306993 0.75 24.2 24 2 abnormal cellular cholesterol metabolism 0.0862439221712749 0.270948434330732 0.925424733306993 0.75 24.2 24 2 liver cysts 0.0862439221712749 0.270948434330732 0.925424733306993 0.75 24.2 24 2 abnormal platelet shape 0.0862439221712749 0.270948434330732 0.925424733306993 0.75 24.2 24 2 pulmonary interstitial fibrosis 0.0862439221712749 0.270948434330732 0.925424733306993 0.75 24.2 24 2 abnormal eyelid aperture 0.0862439221712749 0.270948434330732 0.925424733306993 0.75 24.2 24 2 binucleate 0.0862439221712749 0.270948434330732 0.925424733306993 0.75 24.2 24 2 small frontal bone 0.0862439221712749 0.270948434330732 0.925424733306993 0.75 24.2 24 2 decreased susceptibility to autoimmune disorder 0.0862439221712749 0.270948434330732 0.925424733306993 0.75 24.2 24 2 enlarged inguinal lymph nodes 0.0862439221712749 0.270948434330732 0.925424733306993 0.75 24.2 24 2 abnormal frontonasal prominence morphology 0.0862439221712749 0.270948434330732 0.925424733306993 0.75 24.2 24 2 skin fibrosis 0.0862439221712749 0.270948434330732 0.925424733306993 0.75 24.2 24 2 abnormal olfactory bulb glomerular layer morphology 0.0862439221712749 0.270948434330732 0.925424733306993 0.75 24.2 24 2 increased caudal vertebrae number 0.0862439221712749 0.270948434330732 0.925424733306993 0.75 24.2 24 2 abnormal brain ependyma morphology 0.0862439221712749 0.270948434330732 0.925424733306993 0.75 24.2 24 2 pleural effusion 0.0862439221712749 0.270948434330732 0.925424733306993 0.75 24.2 24 2 heart right ventricle hypoplasia 0.0862439221712749 0.270948434330732 0.925424733306993 0.75 24.2 24 2 abnormal hepatic vein morphology 0.0862439221712749 0.270948434330732 0.925424733306993 0.75 24.2 24 2 delayed suture closure 0.0862439221712749 0.270948434330732 0.925424733306993 0.75 24.2 24 2 abnormal visual evoked potential 0.0862439221712749 0.270948434330732 0.925424733306993 0.75 24.2 24 2 lung situs inversus 0.0862439221712749 0.270948434330732 0.925424733306993 0.75 24.2 24 2 decreased lung compliance 0.0862439221712749 0.270948434330732 0.925424733306993 0.75 24.2 24 2 abnormal maxillary prominence morphology 0.0862439221712749 0.270948434330732 0.925424733306993 0.75 24.2 24 2 lethality during fetal growth through weaning, incomplete penetrance 0.0862439221712749 0.270948434330732 0.925424733306993 0.75 24.2 24 2 impaired neuron differentiation 0.0862439221712749 0.270948434330732 0.925424733306993 0.75 24.2 24 2 decreased cranium length 0.0862439221712749 0.270948434330732 0.925424733306993 0.75 24.2 24 2 abnormal heart echocardiography feature 0.0862439221712749 0.270948434330732 0.925424733306993 0.75 24.2 24 2 prolonged PQ interval 0.0862439221712749 0.270948434330732 0.925424733306993 0.75 24.2 24 2 increased cornea thickness 0.0862439221712749 0.270948434330732 0.925424733306993 0.75 24.2 24 2 small thymus medulla 0.0862439221712749 0.270948434330732 0.925424733306993 0.75 24.2 24 2 absent hypoglossal canal 0.0862439221712749 0.270948434330732 0.925424733306993 0.75 24.2 24 2 retropleural edema 0.0862439221712749 0.270948434330732 0.925424733306993 0.75 24.2 24 2 decreased white adipose tissue mass 0.0862439221712749 0.270948434330732 0.925424733306993 0.75 24.2 24 2 small superior cervical ganglion 0.0011435960079729 0.00937296563371532 0.925424733306993 0.75 24.2 24 2 reddish skin 0.0011435960079729 0.00937296563371532 0.925424733306993 0.75 24.2 24 2 increased bone resorption 0.0011435960079729 0.00937296563371532 0.925424733306993 0.75 24.2 24 2 osteoporosis 4.48644444123737e-05 0.000603244894463673 0.925424733306993 0.75 24.2 24 2 decreased sensitivity to induced morbidity/mortality 4.48644444123737e-05 0.000603244894463673 0.925424733306993 0.75 24.2 24 2 perinatal lethality 0.00010005481508361 0.00122003113980627 0.925424733306993 0.75 24.2 24 2 abnormal cell proliferation 0.00604637820367578 0.0368636416216752 0.925424733306993 0.75 24.2 24 2 abnormal circulating enzyme level 0.00604637820367578 0.0368636416216752 0.925424733306993 0.75 24.2 24 2 brain inflammation 0.00604637820367578 0.0368636416216752 0.925424733306993 0.75 24.2 24 2 spleen atrophy 0.00604637820367578 0.0368636416216752 0.925424733306993 0.75 24.2 24 2 decreased circulating VLDL cholesterol level 0.00604637820367578 0.0368636416216752 0.925424733306993 0.75 24.2 24 2 preweaning lethality, incomplete penetrance 1.88503844405743e-35 9.37806625918574e-33 0.923162081147318 0.748166259168704 24.2 24 2 abnormal gastrulation 1.5409459968263e-05 0.0002351597035034 0.91937620563832 0.745098039215686 24.2 24 2 abnormal blood vessel morphology 3.14398522212484e-13 1.95516581000888e-11 0.919042493766945 0.744827586206897 24.2 24 2 neuron degeneration 3.41613827875764e-05 0.0004681897503256 0.918861437326092 0.74468085106383 24.2 24 2 abnormal T-helper 1 physiology 3.41613827875764e-05 0.0004681897503256 0.918861437326092 0.74468085106383 24.2 24 2 failure of heart looping 0.00016954305881032 0.0018954532979356 0.917515120201805 0.743589743589744 24.2 24 2 abnormal response to injury 0.00016954305881032 0.0018954532979356 0.917515120201805 0.743589743589744 24.2 24 2 increased granulocyte number 2.27897389290926e-07 5.61281936496216e-06 0.917087573547471 0.743243243243243 24.2 24 2 abnormal T cell activation 2.27897389290926e-07 5.61281936496216e-06 0.917087573547471 0.743243243243243 24.2 24 2 abnormal embryonic epiblast morphology 0.000380079005811099 0.00375177193236154 0.916611164418355 0.742857142857143 24.2 24 2 decreased triglyceride level 0.000380079005811099 0.00375177193236154 0.916611164418355 0.742857142857143 24.2 24 2 decreased IgM level 3.50969112614492e-09 1.20418712776352e-07 0.91588427213888 0.742268041237113 24.2 24 2 pericardial effusion 2.41099984023448e-06 4.61335546352559e-05 0.915473929723047 0.741935483870968 24.2 24 2 increased lung adenoma incidence 0.000856738889427498 0.00751724157831005 0.915473929723047 0.741935483870968 24.2 24 2 abnormal postnatal growth/weight/body size 0.000856738889427498 0.00751724157831005 0.915473929723047 0.741935483870968 24.2 24 2 abnormal capillary morphology 0.000856738889427498 0.00751724157831005 0.915473929723047 0.741935483870968 24.2 24 2 abnormal mitochondrial ATP synthesis coupled electron transport 0.000856738889427498 0.00751724157831005 0.915473929723047 0.741935483870968 24.2 24 2 abnormal atrioventricular cushion morphology 0.00194460851057174 0.0146582232425673 0.9139997365995 0.740740740740741 24.2 24 2 abnormal trigeminal nerve morphology 0.00194460851057174 0.0146582232425673 0.9139997365995 0.740740740740741 24.2 24 2 increased brain weight 0.00194460851057174 0.0146582232425673 0.9139997365995 0.740740740740741 24.2 24 2 abnormal bone trabecula morphology 0.00194460851057174 0.0146582232425673 0.9139997365995 0.740740740740741 24.2 24 2 abnormal interventricular septum morphology 2.59021790660584e-05 0.000378460600904826 0.9130857368629 0.74 24.2 24 2 decreased bone marrow cell number 3.81365340916291e-07 8.78376190304883e-06 0.912747682165802 0.73972602739726 24.2 24 2 astrocytosis 3.81365340916291e-07 8.78376190304883e-06 0.912747682165802 0.73972602739726 24.2 24 2 hydroencephaly 2.00074882303631e-10 8.02719789887551e-09 0.91201278065037 0.739130434782609 24.2 24 2 abnormal nervous system physiology 2.00074882303631e-10 8.02719789887551e-09 0.91201278065037 0.739130434782609 24.2 24 2 decreased spleen weight 8.35857336944997e-07 1.78471684605209e-05 0.91201278065037 0.739130434782609 24.2 24 2 abnormal immune system morphology 5.74259846471048e-05 0.000753810748336006 0.91201278065037 0.739130434782609 24.2 24 2 abnormal blood vessel physiology 0.00445381097341293 0.0285905930228766 0.91201278065037 0.739130434782609 24.2 24 2 hypotension 0.00445381097341293 0.0285905930228766 0.91201278065037 0.739130434782609 24.2 24 2 abnormal nasal cavity morphology 0.00445381097341293 0.0285905930228766 0.91201278065037 0.739130434782609 24.2 24 2 abnormal B cell morphology 0.00445381097341293 0.0285905930228766 0.91201278065037 0.739130434782609 24.2 24 2 abnormal hematopoietic stem cell physiology 0.00445381097341293 0.0285905930228766 0.91201278065037 0.739130434782609 24.2 24 2 decreased T cell number 5.08873099313971e-14 3.95569323294845e-12 0.91201278065037 0.739130434782609 24.2 24 2 increased T cell number 2.78570960480709e-08 8.29874567899117e-07 0.911403146438705 0.738636363636364 24.2 24 2 decreased inflammatory response 6.07994605826173e-08 1.69484767569746e-06 0.91073545182593 0.738095238095238 24.2 24 2 increased osteoclast cell number 4.03136816606444e-06 7.34654088870718e-05 0.910253836039666 0.737704918032787 24.2 24 2 decreased circulating serum albumin level 4.4776324243581e-09 1.49504841014641e-07 0.909845192342229 0.737373737373737 24.2 24 2 decreased birth weight 9.74983076626375e-09 3.08951643708039e-07 0.909189211670028 0.736842105263158 24.2 24 2 decreased hair follicle number 0.000285050593160815 0.00293608012624235 0.909189211670028 0.736842105263158 24.2 24 2 abnormal triglyceride level 0.0103258760045387 0.0567011403118985 0.909189211670028 0.736842105263158 24.2 24 2 abnormal stationary movement 0.0103258760045387 0.0567011403118985 0.909189211670028 0.736842105263158 24.2 24 2 unresponsive to tactile stimuli 0.0103258760045387 0.0567011403118985 0.909189211670028 0.736842105263158 24.2 24 2 decreased eye pigmentation 0.0103258760045387 0.0567011403118985 0.909189211670028 0.736842105263158 24.2 24 2 increased liver cholesterol level 0.0103258760045387 0.0567011403118985 0.909189211670028 0.736842105263158 24.2 24 2 hemorrhage 2.07757659591928e-19 3.3341753434511e-17 0.908360163756652 0.736170212765957 24.2 24 2 abnormal forebrain development 6.35307651556842e-07 1.3840448801925e-05 0.908287238245753 0.736111111111111 24.2 24 2 atrioventricular septal defect 1.95729446791451e-05 0.000294185497820988 0.907963889282333 0.735849056603774 24.2 24 2 abnormal brown adipose tissue morphology 0.000639090304706563 0.00587703191481544 0.907279150300974 0.735294117647059 24.2 24 2 abnormal direction of heart looping 0.000639090304706563 0.00587703191481544 0.907279150300974 0.735294117647059 24.2 24 2 decreased cytotoxic T cell cytolysis 0.000639090304706563 0.00587703191481544 0.907279150300974 0.735294117647059 24.2 24 2 abnormal neural tube morphology 1.07140634722662e-13 7.30170764034583e-12 0.906383072127837 0.734567901234568 24.2 24 2 abnormal visceral yolk sac morphology 2.20497963497627e-07 5.51244908744067e-06 0.905901004756213 0.734177215189873 24.2 24 2 abnormal immune system physiology 8.91913526815369e-11 3.89234192623374e-09 0.905523126139101 0.733870967741935 24.2 24 2 prenatal lethality, incomplete penetrance 3.008956037293e-24 7.87871383449087e-22 0.905130331260787 0.733552631578947 24.2 24 2 abnormal humoral immune response 2.59935618332212e-09 9.3034510877896e-08 0.904859739233505 0.733333333333333 24.2 24 2 muscular ventricular septal defect 6.70461223996929e-06 0.000113069308114736 0.904859739233505 0.733333333333333 24.2 24 2 abnormal microglial cell physiology 0.00144076053754955 0.0114684538788944 0.904859739233505 0.733333333333333 24.2 24 2 abnormal fontanelle morphology 0.0243596786742308 0.109475520690423 0.904859739233505 0.733333333333333 24.2 24 2 increased airway responsiveness 0.0243596786742308 0.109475520690423 0.904859739233505 0.733333333333333 24.2 24 2 decreased brown adipose tissue mass 0.0243596786742308 0.109475520690423 0.904859739233505 0.733333333333333 24.2 24 2 abnormal cell migration 9.58706292448173e-05 0.00118058510023011 0.904859739233504 0.733333333333333 24.2 24 2 abnormal liver morphology 1.01690044635055e-14 8.57471139083724e-13 0.903021527472746 0.731843575418994 24.2 24 2 decreased white adipose tissue amount 2.30594207568381e-06 4.46383728658636e-05 0.902404217553088 0.73134328358209 24.2 24 2 distended pericardium 3.25041208701981e-05 0.000456802263641909 0.901695893991429 0.730769230769231 24.2 24 2 abnormal skin condition 3.25041208701981e-05 0.000456802263641909 0.901695893991429 0.730769230769231 24.2 24 2 abnormal female meiosis 3.25041208701981e-05 0.000456802263641909 0.901695893991429 0.730769230769231 24.2 24 2 decreased Peyer's patch number 0.0032706805041344 0.0223818920331068 0.901695893991429 0.730769230769231 24.2 24 2 increased circulating alanine transaminase level 3.6453303504978e-07 8.47454135220866e-06 0.901695893991429 0.730769230769231 24.2 24 2 decreased rib number 5.80871464665852e-08 1.6419520094958e-06 0.901162661647259 0.730337078651685 24.2 24 2 decreased susceptibility to hepatic steatosis 5.05339927275169e-06 8.69919078959849e-05 0.900942597505221 0.73015873015873 24.2 24 2 increased circulating aspartate transaminase level 5.05339927275169e-06 8.69919078959849e-05 0.900942597505221 0.73015873015873 24.2 24 2 abnormal vocalization 0.000475304902138332 0.00458263931809729 0.900413254028426 0.72972972972973 24.2 24 2 increased circulating phosphate level 0.000475304902138332 0.00458263931809729 0.900413254028426 0.72972972972973 24.2 24 2 curly tail 7.17810671812349e-05 0.000910996962312866 0.899718490715132 0.729166666666667 24.2 24 2 thymus atrophy 7.17810671812349e-05 0.000910996962312866 0.899718490715132 0.729166666666667 24.2 24 2 decreased birth body size 1.13607209101657e-09 4.21787959164735e-08 0.898365530578719 0.728070175438597 24.2 24 2 increased mean corpuscular hemoglobin 1.52942035515245e-08 4.6680161146524e-07 0.897381559570418 0.727272727272727 24.2 24 2 enlarged pericardium 0.00106478170617693 0.00881412477242968 0.897381559570418 0.727272727272727 24.2 24 2 abnormal ovarian folliculogenesis 0.00106478170617693 0.00881412477242968 0.897381559570418 0.727272727272727 24.2 24 2 abnormal T cell subpopulation ratio 0.00106478170617693 0.00881412477242968 0.897381559570418 0.727272727272727 24.2 24 2 decreased sensitivity to xenobiotic induced morbidity/mortality 0.00106478170617693 0.00881412477242968 0.897381559570418 0.727272727272727 24.2 24 2 abnormal cytokine secretion 1.6976140130331e-12 9.3840330164885e-11 0.897381559570418 0.727272727272727 24.2 24 2 lethality, incomplete penetrance 0.000158899652418393 0.00179257544394899 0.897381559570418 0.727272727272727 24.2 24 2 abnormal abdominal fat pad morphology 0.00749210003159746 0.0445979167970934 0.897381559570418 0.727272727272727 24.2 24 2 abnormal long bone epiphysis morphology 0.00749210003159746 0.0445979167970934 0.897381559570418 0.727272727272727 24.2 24 2 abnormal facial nerve morphology 0.00749210003159746 0.0445979167970934 0.897381559570418 0.727272727272727 24.2 24 2 abnormal germ layer development 0.00749210003159746 0.0445979167970934 0.897381559570418 0.727272727272727 24.2 24 2 increased activated T cell number 0.00749210003159746 0.0445979167970934 0.897381559570418 0.727272727272727 24.2 24 2 prolonged PR interval 0.00749210003159746 0.0445979167970934 0.897381559570418 0.727272727272727 24.2 24 2 increased adenoma incidence 0.00749210003159746 0.0445979167970934 0.897381559570418 0.727272727272727 24.2 24 2 absent semicircular canals 0.05902587296083 0.211718614261088 0.897381559570418 0.727272727272727 24.2 24 2 decreased atrioventricular cushion size 0.05902587296083 0.211718614261088 0.897381559570418 0.727272727272727 24.2 24 2 abnormal awl hair morphology 0.05902587296083 0.211718614261088 0.897381559570418 0.727272727272727 24.2 24 2 abnormal food preference 0.05902587296083 0.211718614261088 0.897381559570418 0.727272727272727 24.2 24 2 vasculitis 0.05902587296083 0.211718614261088 0.897381559570418 0.727272727272727 24.2 24 2 patent ductus arteriosus 0.05902587296083 0.211718614261088 0.897381559570418 0.727272727272727 24.2 24 2 abnormal radial glial cell morphology 0.05902587296083 0.211718614261088 0.897381559570418 0.727272727272727 24.2 24 2 pathological neovascularization 0.05902587296083 0.211718614261088 0.897381559570418 0.727272727272727 24.2 24 2 abnormal hair medulla 0.05902587296083 0.211718614261088 0.897381559570418 0.727272727272727 24.2 24 2 abnormal coronal suture morphology 0.05902587296083 0.211718614261088 0.897381559570418 0.727272727272727 24.2 24 2 cyclopia 0.05902587296083 0.211718614261088 0.897381559570418 0.727272727272727 24.2 24 2 abnormal superovulation 0.05902587296083 0.211718614261088 0.897381559570418 0.727272727272727 24.2 24 2 abnormal palatal shelf elevation 0.05902587296083 0.211718614261088 0.897381559570418 0.727272727272727 24.2 24 2 aberrant origin of the right subclavian artery 0.05902587296083 0.211718614261088 0.897381559570418 0.727272727272727 24.2 24 2 aorta dilation 0.05902587296083 0.211718614261088 0.897381559570418 0.727272727272727 24.2 24 2 edema 9.7127131987486e-14 6.80573917799638e-12 0.896729392739334 0.726744186046512 24.2 24 2 reduced fertility 2.25588508716492e-11 1.05420399126175e-09 0.896574561765049 0.726618705035971 24.2 24 2 seminiferous tubule degeneration 1.30825477475427e-06 2.64575914813108e-05 0.895844947310879 0.726027397260274 24.2 24 2 small lung 5.36329366816598e-05 0.000711144065269552 0.895182094963628 0.725490196078431 24.2 24 2 liver inflammation 6.50058427346535e-10 2.48772359696078e-08 0.89457724219676 0.725 24.2 24 2 microcephaly 2.8545953191625e-06 5.39985236229407e-05 0.894130177108206 0.72463768115942 24.2 24 2 abnormal outer ear morphology 0.00239797837316197 0.017140721848392 0.893513535606752 0.724137931034483 24.2 24 2 increased susceptibility to induced arthritis 0.00239797837316197 0.017140721848392 0.893513535606752 0.724137931034483 24.2 24 2 abnormal CD8-positive, alpha-beta T cell physiology 0.00239797837316197 0.017140721848392 0.893513535606752 0.724137931034483 24.2 24 2 abnormal behavior 9.22309972611338e-21 1.63874718347907e-18 0.892136073835519 0.723021582733813 24.2 24 2 abnormal lipid level 3.39589423802657e-07 7.96913860102934e-06 0.891975646560957 0.72289156626506 24.2 24 2 increased susceptibility to bacterial infection induced morbidity/mortality 2.14056772916222e-06 4.15989236428985e-05 0.891149743184512 0.722222222222222 24.2 24 2 neurodegeneration 4.00067813298293e-05 0.000542326259171392 0.891149743184512 0.722222222222222 24.2 24 2 heart right ventricle hypertrophy 0.000785639690957893 0.00696712560163194 0.891149743184512 0.722222222222222 24.2 24 2 cortical renal glomerulopathies 0.0173721501033903 0.0843723760424559 0.891149743184512 0.722222222222222 24.2 24 2 right pulmonary isomerism 0.0173721501033903 0.0843723760424559 0.891149743184512 0.722222222222222 24.2 24 2 abnormal mammary gland morphology 0.0173721501033903 0.0843723760424559 0.891149743184512 0.722222222222222 24.2 24 2 absent spleen 0.0173721501033903 0.0843723760424559 0.891149743184512 0.722222222222222 24.2 24 2 abnormal iron level 0.0173721501033903 0.0843723760424559 0.891149743184512 0.722222222222222 24.2 24 2 abnormal thymus medulla morphology 0.0173721501033903 0.0843723760424559 0.891149743184512 0.722222222222222 24.2 24 2 abnormal bile duct morphology 0.0173721501033903 0.0843723760424559 0.891149743184512 0.722222222222222 24.2 24 2 increased circulating glycerol level 0.0173721501033903 0.0843723760424559 0.891149743184512 0.722222222222222 24.2 24 2 decreased activity of thyroid 0.0173721501033903 0.0843723760424559 0.891149743184512 0.722222222222222 24.2 24 2 abnormal eye anterior chamber morphology 0.0173721501033903 0.0843723760424559 0.891149743184512 0.722222222222222 24.2 24 2 increased susceptibility to autoimmune disorder 0.0173721501033903 0.0843723760424559 0.891149743184512 0.722222222222222 24.2 24 2 abnormal pregnancy 0.0173721501033903 0.0843723760424559 0.891149743184512 0.722222222222222 24.2 24 2 small thoracic cage 0.0173721501033903 0.0843723760424559 0.891149743184512 0.722222222222222 24.2 24 2 abnormal testis morphology 2.28923326204254e-09 8.37421726372181e-08 0.890553656399773 0.721739130434783 24.2 24 2 abnormal somite development 7.37714811343998e-07 1.58880137940969e-05 0.890282021915588 0.721518987341772 24.2 24 2 increased double-negative T cell number 1.36235969018407e-05 0.000210488803064153 0.890025973016562 0.721311475409836 24.2 24 2 abnormal vasculogenesis 0.000261376401411918 0.00275497372250909 0.88955555759742 0.720930232558139 24.2 24 2 abnormal left-right axis patterning 0.000261376401411918 0.00275497372250909 0.88955555759742 0.720930232558139 24.2 24 2 kidney failure 0.000261376401411918 0.00275497372250909 0.88955555759742 0.720930232558139 24.2 24 2 ventricular septal defect 9.76267951340924e-11 4.18701125682853e-09 0.889133567294954 0.720588235294118 24.2 24 2 decreased circulating alanine transaminase level 4.66361670591369e-06 8.13527410874212e-05 0.889133567294954 0.720588235294118 24.2 24 2 decreased susceptibility to injury 4.66361670591369e-06 8.13527410874212e-05 0.889133567294954 0.720588235294118 24.2 24 2 decreased circulating alkaline phosphatase level 8.79055905162824e-05 0.00108788635029479 0.888407743974714 0.72 24.2 24 2 abnormal circulating protein level 8.79055905162824e-05 0.00108788635029479 0.888407743974714 0.72 24.2 24 2 mandible hypoplasia 0.00543635464685886 0.0336391347862224 0.888407743974714 0.72 24.2 24 2 delayed bone ossification 1.60313979867229e-06 3.17753804716918e-05 0.888407743974713 0.72 24.2 24 2 decreased brain weight 2.9802779943883e-05 0.000428303249048637 0.887541849487409 0.719298245614035 24.2 24 2 decreased circulating HDL cholesterol level 4.52731092084442e-10 1.74599781637217e-08 0.886865369419202 0.71875 24.2 24 2 decreased caudal vertebrae number 1.01666345350459e-05 0.000163753558664438 0.886865369419202 0.71875 24.2 24 2 neonatal lethality 0.0017567583376774 0.0134047127759893 0.886865369419202 0.71875 24.2 24 2 increased sensitivity to xenobiotic induced morbidity/mortality 8.01627211790482e-09 2.58967232380367e-07 0.886164290075788 0.718181818181818 24.2 24 2 increased autoantibody level 0.000579069771507533 0.00541517314520672 0.885876667781053 0.717948717948718 24.2 24 2 embryonic lethality during organogenesis, incomplete penetrance 8.94084403976844e-17 1.08489509994751e-14 0.885188875337124 0.717391304347826 24.2 24 2 atrial septal defect 0.000193460880915936 0.00213881751679284 0.885188875337124 0.717391304347826 24.2 24 2 abnormal coat/hair pigmentation 9.70594914713848e-09 3.08951643708039e-07 0.881356888863803 0.714285714285714 24.2 24 2 gliosis 1.64885263592415e-05 0.000250857549349317 0.881356888863803 0.714285714285714 24.2 24 2 abnormal seminal vesicle morphology 4.84106641313534e-05 0.000647427564659901 0.881356888863803 0.714285714285714 24.2 24 2 thick pulmonary interalveolar septum 0.00128661855194524 0.0103574875338634 0.881356888863803 0.714285714285714 24.2 24 2 abnormal artery morphology 0.00128661855194524 0.0103574875338634 0.881356888863803 0.714285714285714 24.2 24 2 abnormal midbrain development 0.00128661855194524 0.0103574875338634 0.881356888863803 0.714285714285714 24.2 24 2 holoprosencephaly 0.00128661855194524 0.0103574875338634 0.881356888863803 0.714285714285714 24.2 24 2 abnormal spleen germinal center morphology 0.00394713976706882 0.0259405816924272 0.881356888863803 0.714285714285714 24.2 24 2 abnormal mitotic spindle morphology 0.00394713976706882 0.0259405816924272 0.881356888863803 0.714285714285714 24.2 24 2 prolonged QRS complex duration 0.00394713976706882 0.0259405816924272 0.881356888863803 0.714285714285714 24.2 24 2 midline facial cleft 0.0409824642623443 0.157442285486612 0.881356888863803 0.714285714285714 24.2 24 2 absent atrioventricular cushions 0.0409824642623443 0.157442285486612 0.881356888863803 0.714285714285714 24.2 24 2 megacephaly 0.0409824642623443 0.157442285486612 0.881356888863803 0.714285714285714 24.2 24 2 irregularly shaped pupil 0.0409824642623443 0.157442285486612 0.881356888863803 0.714285714285714 24.2 24 2 abnormal adrenal gland secretion 0.0409824642623443 0.157442285486612 0.881356888863803 0.714285714285714 24.2 24 2 decreased coping response 0.0409824642623443 0.157442285486612 0.881356888863803 0.714285714285714 24.2 24 2 absent olfactory bulb 0.0409824642623443 0.157442285486612 0.881356888863803 0.714285714285714 24.2 24 2 decreased CNS synapse formation 0.0409824642623443 0.157442285486612 0.881356888863803 0.714285714285714 24.2 24 2 abnormal viscerocranium morphology 0.0409824642623443 0.157442285486612 0.881356888863803 0.714285714285714 24.2 24 2 increased pulmonary respiratory rate 0.0409824642623443 0.157442285486612 0.881356888863803 0.714285714285714 24.2 24 2 pulmonary alveolar hemorrhage 0.0409824642623443 0.157442285486612 0.881356888863803 0.714285714285714 24.2 24 2 abnormal renal tubule epithelial cell primary cilium morphology 0.0409824642623443 0.157442285486612 0.881356888863803 0.714285714285714 24.2 24 2 asymmetric rib joints 0.149857888624548 0.395094327454757 0.881356888863803 0.714285714285714 24.2 24 2 polyphalangy 0.149857888624548 0.395094327454757 0.881356888863803 0.714285714285714 24.2 24 2 maxilla hypoplasia 0.149857888624548 0.395094327454757 0.881356888863803 0.714285714285714 24.2 24 2 skin photosensitivity 0.149857888624548 0.395094327454757 0.881356888863803 0.714285714285714 24.2 24 2 absent epidermis stratum corneum 0.149857888624548 0.395094327454757 0.881356888863803 0.714285714285714 24.2 24 2 excessive tearing 0.149857888624548 0.395094327454757 0.881356888863803 0.714285714285714 24.2 24 2 absent amniotic folds 0.149857888624548 0.395094327454757 0.881356888863803 0.714285714285714 24.2 24 2 abnormal inhibitory postsynaptic potential 0.149857888624548 0.395094327454757 0.881356888863803 0.714285714285714 24.2 24 2 abnormal sinus venosus morphology 0.149857888624548 0.395094327454757 0.881356888863803 0.714285714285714 24.2 24 2 increased ectoderm apoptosis 0.149857888624548 0.395094327454757 0.881356888863803 0.714285714285714 24.2 24 2 abnormal optic tract morphology 0.149857888624548 0.395094327454757 0.881356888863803 0.714285714285714 24.2 24 2 abnormal organ of Corti supporting cell morphology 0.149857888624548 0.395094327454757 0.881356888863803 0.714285714285714 24.2 24 2 abnormal strial marginal cell morphology 0.149857888624548 0.395094327454757 0.881356888863803 0.714285714285714 24.2 24 2 absent endocochlear potential 0.149857888624548 0.395094327454757 0.881356888863803 0.714285714285714 24.2 24 2 abnormal cochlear nerve compound action potential 0.149857888624548 0.395094327454757 0.881356888863803 0.714285714285714 24.2 24 2 abnormal negative T cell selection 0.149857888624548 0.395094327454757 0.881356888863803 0.714285714285714 24.2 24 2 abnormal MHC II cell surface expression on macrophages 0.149857888624548 0.395094327454757 0.881356888863803 0.714285714285714 24.2 24 2 abnormal talus morphology 0.149857888624548 0.395094327454757 0.881356888863803 0.714285714285714 24.2 24 2 increased thyroid-stimulating hormone level 0.149857888624548 0.395094327454757 0.881356888863803 0.714285714285714 24.2 24 2 absent thyroid gland 0.149857888624548 0.395094327454757 0.881356888863803 0.714285714285714 24.2 24 2 abnormal renal/urinary system physiology 0.149857888624548 0.395094327454757 0.881356888863803 0.714285714285714 24.2 24 2 abnormal body temperature 0.149857888624548 0.395094327454757 0.881356888863803 0.714285714285714 24.2 24 2 increased keratinocyte apoptosis 0.149857888624548 0.395094327454757 0.881356888863803 0.714285714285714 24.2 24 2 absent popliteal lymph nodes 0.149857888624548 0.395094327454757 0.881356888863803 0.714285714285714 24.2 24 2 abnormal uterus physiology 0.149857888624548 0.395094327454757 0.881356888863803 0.714285714285714 24.2 24 2 abnormal sperm annulus morphology 0.149857888624548 0.395094327454757 0.881356888863803 0.714285714285714 24.2 24 2 abnormal cerebellum white matter morphology 0.149857888624548 0.395094327454757 0.881356888863803 0.714285714285714 24.2 24 2 decreased T-helper 17 cell number 0.149857888624548 0.395094327454757 0.881356888863803 0.714285714285714 24.2 24 2 decreased skeletal muscle glycogen level 0.149857888624548 0.395094327454757 0.881356888863803 0.714285714285714 24.2 24 2 heart right ventricle outflow tract stenosis 0.149857888624548 0.395094327454757 0.881356888863803 0.714285714285714 24.2 24 2 abnormal T wave 0.149857888624548 0.395094327454757 0.881356888863803 0.714285714285714 24.2 24 2 long stride length 0.149857888624548 0.395094327454757 0.881356888863803 0.714285714285714 24.2 24 2 heart block 0.149857888624548 0.395094327454757 0.881356888863803 0.714285714285714 24.2 24 2 abnormal conotruncal ridge morphology 0.149857888624548 0.395094327454757 0.881356888863803 0.714285714285714 24.2 24 2 abnormal impulsive behavior control 0.149857888624548 0.395094327454757 0.881356888863803 0.714285714285714 24.2 24 2 increased right ventricle systolic pressure 0.149857888624548 0.395094327454757 0.881356888863803 0.714285714285714 24.2 24 2 dilated pulmonary alveolar ducts 0.149857888624548 0.395094327454757 0.881356888863803 0.714285714285714 24.2 24 2 abnormal tricarboxylic acid cycle 0.149857888624548 0.395094327454757 0.881356888863803 0.714285714285714 24.2 24 2 increased circulating lactate dehydrogenase level 0.149857888624548 0.395094327454757 0.881356888863803 0.714285714285714 24.2 24 2 parturition failure 0.149857888624548 0.395094327454757 0.881356888863803 0.714285714285714 24.2 24 2 decreased CD8-positive, naive alpha-beta T cell number 0.149857888624548 0.395094327454757 0.881356888863803 0.714285714285714 24.2 24 2 decreased areal bone mineral density 0.149857888624548 0.395094327454757 0.881356888863803 0.714285714285714 24.2 24 2 decreased femur compact bone thickness 0.149857888624548 0.395094327454757 0.881356888863803 0.714285714285714 24.2 24 2 abnormal Mullerian duct topology 0.149857888624548 0.395094327454757 0.881356888863803 0.714285714285714 24.2 24 2 absent connection between subcutaneous lymph vessels and lymph sac 0.149857888624548 0.395094327454757 0.881356888863803 0.714285714285714 24.2 24 2 increased abdominal adipose tissue amount 0.149857888624548 0.395094327454757 0.881356888863803 0.714285714285714 24.2 24 2 small spleen 2.31569742051043e-07 5.67516978671891e-06 0.881356888863803 0.714285714285714 24.2 24 2 abnormal pancreas morphology 0.000426530821354805 0.00412838684093416 0.881356888863803 0.714285714285714 24.2 24 2 abnormal reproductive system morphology 0.000426530821354805 0.00412838684093416 0.881356888863803 0.714285714285714 24.2 24 2 abnormal anxiety-related response 0.0124299455934324 0.0662797206080668 0.881356888863803 0.714285714285714 24.2 24 2 decreased cochlear outer hair cell number 0.0124299455934324 0.0662797206080668 0.881356888863803 0.714285714285714 24.2 24 2 complete atrioventricular septal defect 0.0124299455934324 0.0662797206080668 0.881356888863803 0.714285714285714 24.2 24 2 increased bone ossification 0.0124299455934324 0.0662797206080668 0.881356888863803 0.714285714285714 24.2 24 2 increased muscle cell glucose uptake 0.0124299455934324 0.0662797206080668 0.881356888863803 0.714285714285714 24.2 24 2 decreased total body fat amount 6.78464185656497e-23 1.40639971818378e-20 0.879245854399459 0.712574850299401 24.2 24 2 abnormal spermatogenesis 3.20763640900556e-13 1.97012236232132e-11 0.878482899008812 0.71195652173913 24.2 24 2 increased susceptibility to injury 0.000105750682349932 0.00127696515701678 0.877967054675865 0.711538461538462 24.2 24 2 trabecula carnea hypoplasia 0.000314048017153346 0.00320557699009836 0.87743974713552 0.711111111111111 24.2 24 2 abnormal ovarian follicle morphology 0.000314048017153346 0.00320557699009836 0.87743974713552 0.711111111111111 24.2 24 2 irregular heartbeat 0.000314048017153346 0.00320557699009836 0.87743974713552 0.711111111111111 24.2 24 2 small testis 7.58952404646589e-19 1.17993381659899e-16 0.876247573566042 0.710144927536232 24.2 24 2 perimembraneous ventricular septal defect 9.09571910345421e-06 0.000149601813025911 0.876247573566042 0.710144927536232 24.2 24 2 abnormal bone structure 1.3500380038627e-13 8.95525209228925e-12 0.875876949658432 0.709844559585492 24.2 24 2 autoimmune response 0.00286836901073679 0.0199861846336352 0.875670715387262 0.709677419354839 24.2 24 2 decreased double-negative T cell number 0.00286836901073679 0.0199861846336352 0.875670715387262 0.709677419354839 24.2 24 2 decreased susceptibility to bacterial infection induced morbidity/mortality 0.00286836901073679 0.0199861846336352 0.875670715387262 0.709677419354839 24.2 24 2 increased circulating creatinine level 8.02190896941774e-07 1.72021539322643e-05 0.87520788731359 0.709302325581395 24.2 24 2 postnatal growth retardation 8.24659084509129e-40 5.12834868179115e-37 0.87502033606805 0.709150326797386 24.2 24 2 abnormal head morphology 7.8129506224613e-05 0.000979078824855037 0.874947020581157 0.709090909090909 24.2 24 2 abnormal rostral-caudal axis patterning 7.8129506224613e-05 0.000979078824855037 0.874947020581157 0.709090909090909 24.2 24 2 abnormal osteoclast morphology 0.000231178093189212 0.0024933561667908 0.874012248123272 0.708333333333333 24.2 24 2 abnormal vasodilation 0.00892097559683811 0.0497554412491812 0.874012248123272 0.708333333333333 24.2 24 2 small lymph nodes 0.00892097559683811 0.0497554412491812 0.874012248123272 0.708333333333333 24.2 24 2 abnormal primitive streak formation 0.00892097559683811 0.0497554412491812 0.874012248123272 0.708333333333333 24.2 24 2 abnormal inner cell mass apoptosis 0.00892097559683811 0.0497554412491812 0.874012248123272 0.708333333333333 24.2 24 2 abnormal truncus arteriosus septation 0.00892097559683811 0.0497554412491812 0.874012248123272 0.708333333333333 24.2 24 2 abnormal brain morphology 1.90172467159393e-11 9.01055261064743e-10 0.873692915917161 0.708074534161491 24.2 24 2 abnormal mammary gland development 0.000690235571470494 0.00625486697279728 0.87275828507001 0.707317073170732 24.2 24 2 Leydig cell hyperplasia 0.000690235571470494 0.00625486697279728 0.87275828507001 0.707317073170732 24.2 24 2 thick ventricular wall 0.000690235571470494 0.00625486697279728 0.87275828507001 0.707317073170732 24.2 24 2 hemopericardium 0.000690235571470494 0.00625486697279728 0.87275828507001 0.707317073170732 24.2 24 2 increased bone trabecula number 0.000690235571470494 0.00625486697279728 0.87275828507001 0.707317073170732 24.2 24 2 lethality at weaning, incomplete penetrance 0.000690235571470494 0.00625486697279728 0.87275828507001 0.707317073170732 24.2 24 2 decreased bone mineral content 3.16788453394737e-14 2.58364353383413e-12 0.872034844846974 0.706730769230769 24.2 24 2 kyphosis 1.15712422112595e-10 4.87855338991662e-09 0.871955748715922 0.706666666666667 24.2 24 2 abnormal neurocranium morphology 5.00757009307878e-06 8.68036976065049e-05 0.871955748715922 0.706666666666667 24.2 24 2 increased bone mineral content 3.99068217363912e-08 1.1610318019798e-06 0.871653877243284 0.706422018348624 24.2 24 2 abnormal thrombosis 0.000170159959719375 0.0018980847524751 0.870987984288935 0.705882352941177 24.2 24 2 short maxilla 0.00208644106970581 0.0151990640573926 0.870987984288935 0.705882352941177 24.2 24 2 increased susceptibility to viral infection induced morbidity/mortality 0.00208644106970581 0.0151990640573926 0.870987984288935 0.705882352941177 24.2 24 2 abnormal glutamate-mediated receptor currents 0.0287433647715491 0.124671525491244 0.870987984288935 0.705882352941177 24.2 24 2 increased brain size 0.0287433647715491 0.124671525491244 0.870987984288935 0.705882352941177 24.2 24 2 increased trabecular bone mass 0.0287433647715491 0.124671525491244 0.870987984288935 0.705882352941177 24.2 24 2 delayed heart development 0.0287433647715491 0.124671525491244 0.870987984288935 0.705882352941177 24.2 24 2 decreased body fat mass 0.0287433647715491 0.124671525491244 0.870987984288935 0.705882352941177 24.2 24 2 abnormal lung development 1.28235843638351e-06 2.60397274326855e-05 0.870987984288935 0.705882352941177 24.2 24 2 abnormal heart morphology 1.63468445533063e-15 1.56395291639806e-13 0.870673775059393 0.705627705627706 24.2 24 2 decreased circulating cholesterol level 1.55392183110836e-12 8.68624843793721e-11 0.869798109993458 0.704918032786885 24.2 24 2 spleen hypoplasia 8.53335621638446e-08 2.33260698772048e-06 0.869605463678953 0.704761904761905 24.2 24 2 azoospermia 4.81205616710131e-11 2.15675490372333e-09 0.869162013671977 0.70440251572327 24.2 24 2 increased cell proliferation 0.000125246858712078 0.00147305702622361 0.868299749769525 0.703703703703704 24.2 24 2 axon degeneration 0.000125246858712078 0.00147305702622361 0.868299749769525 0.703703703703704 24.2 24 2 abnormal type II pneumocyte morphology 0.0064201014888457 0.0389037818599359 0.868299749769525 0.703703703703704 24.2 24 2 abnormal skin appearance 0.0064201014888457 0.0389037818599359 0.868299749769525 0.703703703703704 24.2 24 2 decreased bone ossification 0.0064201014888457 0.0389037818599359 0.868299749769525 0.703703703703704 24.2 24 2 abnormal long bone metaphysis morphology 0.00151915828271322 0.0118461010289941 0.867064614990336 0.702702702702703 24.2 24 2 decreased circulating chloride level 0.00151915828271322 0.0118461010289941 0.867064614990336 0.702702702702703 24.2 24 2 skin inflammation 0.00151915828271322 0.0118461010289941 0.867064614990336 0.702702702702703 24.2 24 2 abnormal respiratory electron transport chain 0.00151915828271322 0.0118461010289941 0.867064614990336 0.702702702702703 24.2 24 2 hepatic necrosis 0.000370692129338675 0.00367369191924285 0.866355069478887 0.702127659574468 24.2 24 2 decreased bone trabecula number 0.000370692129338675 0.00367369191924285 0.866355069478887 0.702127659574468 24.2 24 2 abnormal craniofacial bone morphology 9.21939210430475e-05 0.0011381259483602 0.865894487304789 0.701754385964912 24.2 24 2 increased B cell number 2.60836801561998e-08 7.81724751669241e-07 0.864784366167219 0.700854700854701 24.2 24 2 abnormal enzyme/coenzyme activity 1.20519789126521e-10 5.03853740255835e-09 0.864515674426915 0.700636942675159 24.2 24 2 kidney inflammation 0.000271806620308743 0.00284681670744421 0.863729751086527 0.7 24.2 24 2 abnormal heart tube morphology 0.00463148665625763 0.0291297675282955 0.863729751086527 0.7 24.2 24 2 gastrointestinal hemorrhage 0.00463148665625763 0.0291297675282955 0.863729751086527 0.7 24.2 24 2 increased metastatic potential 0.00463148665625763 0.0291297675282955 0.863729751086527 0.7 24.2 24 2 abnormal response to new environment 0.00463148665625763 0.0291297675282955 0.863729751086527 0.7 24.2 24 2 salivary gland inflammation 0.00463148665625763 0.0291297675282955 0.863729751086527 0.7 24.2 24 2 disorganized myocardium 0.00463148665625763 0.0291297675282955 0.863729751086527 0.7 24.2 24 2 abnormal fat pad morphology 0.00463148665625763 0.0291297675282955 0.863729751086527 0.7 24.2 24 2 decreased insulin secretion 1.12039261655733e-06 2.341997171165e-05 0.863729751086527 0.7 24.2 24 2 abnormal hair texture 0.0203113708732189 0.0932186993489521 0.863729751086527 0.7 24.2 24 2 abnormal Peyer's patch T cell area morphology 0.0203113708732189 0.0932186993489521 0.863729751086527 0.7 24.2 24 2 abnormal induced retinal neovascularization 0.0203113708732189 0.0932186993489521 0.863729751086527 0.7 24.2 24 2 abnormal sperm mitochondrial sheath morphology 0.0203113708732189 0.0932186993489521 0.863729751086527 0.7 24.2 24 2 abnormal epidermis suprabasal layer morphology 0.0992572420711984 0.293581913973967 0.863729751086527 0.7 24.2 24 2 fused cornea and lens 0.0992572420711984 0.293581913973967 0.863729751086527 0.7 24.2 24 2 decreased incidence of induced tumors 0.0992572420711984 0.293581913973967 0.863729751086527 0.7 24.2 24 2 abnormal airway responsiveness 0.0992572420711984 0.293581913973967 0.863729751086527 0.7 24.2 24 2 ketoaciduria 0.0992572420711984 0.293581913973967 0.863729751086527 0.7 24.2 24 2 impaired social transmission of food preference 0.0992572420711984 0.293581913973967 0.863729751086527 0.7 24.2 24 2 impaired basement membrane formation 0.0992572420711984 0.293581913973967 0.863729751086527 0.7 24.2 24 2 abnormal scala media morphology 0.0992572420711984 0.293581913973967 0.863729751086527 0.7 24.2 24 2 cochlear ganglion hypoplasia 0.0992572420711984 0.293581913973967 0.863729751086527 0.7 24.2 24 2 absent seminal vesicle 0.0992572420711984 0.293581913973967 0.863729751086527 0.7 24.2 24 2 abnormal glial cell physiology 0.0992572420711984 0.293581913973967 0.863729751086527 0.7 24.2 24 2 abnormal submandibular gland morphology 0.0992572420711984 0.293581913973967 0.863729751086527 0.7 24.2 24 2 decreased cochlear inner hair cell number 0.0992572420711984 0.293581913973967 0.863729751086527 0.7 24.2 24 2 tachypnea 0.0992572420711984 0.293581913973967 0.863729751086527 0.7 24.2 24 2 vascular smooth muscle hyperplasia 0.0992572420711984 0.293581913973967 0.863729751086527 0.7 24.2 24 2 abnormal developmental vascular remodeling 0.0992572420711984 0.293581913973967 0.863729751086527 0.7 24.2 24 2 absent inguinal lymph nodes 0.0992572420711984 0.293581913973967 0.863729751086527 0.7 24.2 24 2 increased circulating fructosamine level 0.0992572420711984 0.293581913973967 0.863729751086527 0.7 24.2 24 2 increased kidney iron level 0.0992572420711984 0.293581913973967 0.863729751086527 0.7 24.2 24 2 abnormal heart and great artery attachment 0.0992572420711984 0.293581913973967 0.863729751086527 0.7 24.2 24 2 common ventricle 0.0992572420711984 0.293581913973967 0.863729751086527 0.7 24.2 24 2 sinus bradycardia 0.0992572420711984 0.293581913973967 0.863729751086527 0.7 24.2 24 2 abnormal craniofacial morphology 2.1414769357703e-07 5.40804454591739e-06 0.862531790266712 0.699029126213592 24.2 24 2 abnormal fertility/fecundity 1.26586960692143e-05 0.00019866565597584 0.862039477601035 0.698630136986301 24.2 24 2 lung inflammation 2.78626907408125e-09 9.83098485358455e-08 0.861915192785925 0.698529411764706 24.2 24 2 abnormal organ of Corti morphology 0.000807656405838389 0.00714962743602488 0.860860217029761 0.697674418604651 24.2 24 2 impaired glucose tolerance 1.30581212388636e-15 1.29928306326693e-13 0.860744510011343 0.69758064516129 24.2 24 2 increased circulating alkaline phosphatase level 1.05090675590703e-10 4.46859923986111e-09 0.860683085297862 0.697530864197531 24.2 24 2 abnormal skeleton physiology 0.00334830459012847 0.0228502267982019 0.859990661254984 0.696969696969697 24.2 24 2 decreased systemic arterial blood pressure 0.00334830459012847 0.0228502267982019 0.859990661254984 0.696969696969697 24.2 24 2 abnormal rib morphology 4.38055946347017e-09 1.47251914397055e-07 0.85915975240353 0.696296296296296 24.2 24 2 kinked tail 3.37252556853972e-07 7.95180791634365e-06 0.858890928951589 0.696078431372549 24.2 24 2 abnormal epidermal layer morphology 2.71022696156443e-05 0.000391958695749507 0.858364970023878 0.695652173913043 24.2 24 2 abnormal cranial nerve morphology 0.0144367607360193 0.0748155048559331 0.858364970023878 0.695652173913043 24.2 24 2 decreased effector memory CD8-positive, alpha-beta T cell number 0.0144367607360193 0.0748155048559331 0.858364970023878 0.695652173913043 24.2 24 2 increased circulating HDL cholesterol level 2.49754552631509e-07 6.03169368612504e-06 0.857854038494102 0.695238095238095 24.2 24 2 increased hemoglobin content 0.000107406306967594 0.00129381689385903 0.857455685098005 0.694915254237288 24.2 24 2 premature death 1.10598501973265e-49 9.17045912194989e-47 0.856994178114722 0.694541231126597 24.2 24 2 reduced long term depression 0.00242520687237103 0.0173104794692193 0.856874753062031 0.694444444444444 24.2 24 2 cardiac fibrosis 3.76112376691864e-06 6.93021879274823e-05 0.856471517884119 0.694117647058824 24.2 24 2 cardiac hypertrophy 7.15245795272729e-07 1.54710775281819e-05 0.856175263467694 0.693877551020408 24.2 24 2 prenatal lethality 7.88785391684874e-05 0.000985981739606093 0.85576910821937 0.693548387096774 24.2 24 2 decreased body length 1.42463467619639e-16 1.63916516597858e-14 0.855623841013765 0.693430656934307 24.2 24 2 abnormal snout morphology 0.000315080833800622 0.00320557699009836 0.854238215360302 0.692307692307692 24.2 24 2 eyelids open at birth 0.000315080833800622 0.00320557699009836 0.854238215360302 0.692307692307692 24.2 24 2 abnormal nasal bone morphology 0.0103091214679889 0.0567011403118985 0.854238215360302 0.692307692307692 24.2 24 2 no spontaneous movement 0.0103091214679889 0.0567011403118985 0.854238215360302 0.692307692307692 24.2 24 2 increased susceptibility to otitis media 0.0103091214679889 0.0567011403118985 0.854238215360302 0.692307692307692 24.2 24 2 abnormal membranous labyrinth morphology 0.0675112653284748 0.231308004962795 0.854238215360302 0.692307692307692 24.2 24 2 short hair 0.0675112653284748 0.231308004962795 0.854238215360302 0.692307692307692 24.2 24 2 tight skin 0.0675112653284748 0.231308004962795 0.854238215360302 0.692307692307692 24.2 24 2 excessive scratching 0.0675112653284748 0.231308004962795 0.854238215360302 0.692307692307692 24.2 24 2 increased pituitary adenoma incidence 0.0675112653284748 0.231308004962795 0.854238215360302 0.692307692307692 24.2 24 2 abnormal insulin secretion 0.0675112653284748 0.231308004962795 0.854238215360302 0.692307692307692 24.2 24 2 abnormal vestibulocochlear ganglion morphology 0.0675112653284748 0.231308004962795 0.854238215360302 0.692307692307692 24.2 24 2 increased circulating thyroid-stimulating hormone level 0.0675112653284748 0.231308004962795 0.854238215360302 0.692307692307692 24.2 24 2 empty decidua capsularis 0.0675112653284748 0.231308004962795 0.854238215360302 0.692307692307692 24.2 24 2 abnormal aorta tunica media morphology 0.0675112653284748 0.231308004962795 0.854238215360302 0.692307692307692 24.2 24 2 abnormal heart looping 0.00175954445631007 0.0134054114397284 0.854238215360301 0.692307692307692 24.2 24 2 abnormal learning/memory/conditioning 0.000230567999566414 0.0024933561667908 0.852512481591897 0.690909090909091 24.2 24 2 abnormal cytotoxic T cell physiology 0.00127850001403626 0.0103574875338634 0.851978325901676 0.69047619047619 24.2 24 2 abnormal skeletal muscle fiber morphology 3.13109439148692e-05 0.000443794717881693 0.851564543324745 0.690140845070423 24.2 24 2 short limbs 4.34217263965592e-06 7.82692350807544e-05 0.850965272006431 0.689655172413793 24.2 24 2 abnormal retinal pigmentation 4.34217263965592e-06 7.82692350807544e-05 0.850965272006431 0.689655172413793 24.2 24 2 abnormal spermiogenesis 0.000168835197704856 0.0018954532979356 0.850965272006431 0.689655172413793 24.2 24 2 abnormal spinal nerve morphology 0.00738972064241735 0.0444544863313498 0.850965272006431 0.689655172413793 24.2 24 2 scoliosis 0.00531391249146742 0.0330632165998944 0.848306005531411 0.6875 24.2 24 2 failure of primitive streak formation 0.00531391249146742 0.0330632165998944 0.848306005531411 0.6875 24.2 24 2 abnormal heart atrium morphology 0.00531391249146742 0.0330632165998944 0.848306005531411 0.6875 24.2 24 2 poor circulation 0.0466783015252624 0.176462424079165 0.848306005531411 0.6875 24.2 24 2 abnormal extraembryonic endoderm formation 0.0466783015252624 0.176462424079165 0.848306005531411 0.6875 24.2 24 2 abnormal meiosis 0.0466783015252624 0.176462424079165 0.848306005531411 0.6875 24.2 24 2 abnormal olfaction 0.0466783015252624 0.176462424079165 0.848306005531411 0.6875 24.2 24 2 decreased aggression towards mice 0.0466783015252624 0.176462424079165 0.848306005531411 0.6875 24.2 24 2 increased cochlear outer hair cell number 0.0466783015252624 0.176462424079165 0.848306005531411 0.6875 24.2 24 2 small epididymis 0.0466783015252624 0.176462424079165 0.848306005531411 0.6875 24.2 24 2 sepsis 0.0466783015252624 0.176462424079165 0.848306005531411 0.6875 24.2 24 2 blepharitis 0.0466783015252624 0.176462424079165 0.848306005531411 0.6875 24.2 24 2 abnormal thoracic cage shape 0.0466783015252624 0.176462424079165 0.848306005531411 0.6875 24.2 24 2 abnormal pulmonary alveolus wall morphology 0.0466783015252624 0.176462424079165 0.848306005531411 0.6875 24.2 24 2 embryonic lethality between somite formation and embryo turning, incomplete penetrance 0.0466783015252624 0.176462424079165 0.848306005531411 0.6875 24.2 24 2 decreased body weight 6.67770450629424e-67 8.30539497970346e-64 0.847184731621911 0.686591276252019 24.2 24 2 decreased circulating thyroxine level 0.00383150838118342 0.02541567226185 0.846102613309251 0.685714285714286 24.2 24 2 increased insulin sensitivity 7.76915277521431e-09 2.52624412135237e-07 0.845609546518278 0.685314685314685 24.2 24 2 abnormal axon morphology 5.16606175237844e-07 1.16294829041098e-05 0.845449756354537 0.685185185185185 24.2 24 2 abnormal chondrocyte morphology 0.000360722932428916 0.00358919317766771 0.845449756354537 0.685185185185185 24.2 24 2 abnormal neuronal precursor proliferation 0.000360722932428916 0.00358919317766771 0.845449756354537 0.685185185185185 24.2 24 2 increased bone marrow cell number 0.00276903360045718 0.0194027354398232 0.844247125122169 0.684210526315789 24.2 24 2 kyphoscoliosis 0.0326390773175686 0.139861679289323 0.844247125122169 0.684210526315789 24.2 24 2 increased malignant tumor incidence 0.0326390773175686 0.139861679289323 0.844247125122169 0.684210526315789 24.2 24 2 decreased germ cell number 0.0326390773175686 0.139861679289323 0.844247125122169 0.684210526315789 24.2 24 2 decreased fertilization frequency 0.0326390773175686 0.139861679289323 0.844247125122169 0.684210526315789 24.2 24 2 decreased circulating magnesium level 0.0326390773175686 0.139861679289323 0.844247125122169 0.684210526315789 24.2 24 2 decreased susceptibility to weight gain 0.0326390773175686 0.139861679289323 0.844247125122169 0.684210526315789 24.2 24 2 thin interventricular septum 0.0326390773175686 0.139861679289323 0.844247125122169 0.684210526315789 24.2 24 2 intracranial hemorrhage 0.000192719845658042 0.00213537022750281 0.843164757013038 0.683333333333333 24.2 24 2 ataxia 1.08058835753757e-11 5.5421928646901e-10 0.842961143210331 0.683168316831683 24.2 24 2 liver fibrosis 0.00200519559967051 0.0149115816268472 0.842663171791734 0.682926829268293 24.2 24 2 increased tumor growth/size 0.00200519559967051 0.0149115816268472 0.842663171791734 0.682926829268293 24.2 24 2 abnormal cholesterol homeostasis 0.00200519559967051 0.0149115816268472 0.842663171791734 0.682926829268293 24.2 24 2 skin lesions 0.000141028923676549 0.00160186962395167 0.842185471580967 0.682539682539683 24.2 24 2 increased circulating cholesterol level 2.83003078993286e-10 1.12635225439328e-08 0.841295212097266 0.681818181818182 24.2 24 2 abnormal astrocyte morphology 0.00145461148914797 0.0115050749737856 0.841295212097266 0.681818181818182 24.2 24 2 intestinal inflammation 0.0230110432259358 0.104167370381283 0.841295212097266 0.681818181818182 24.2 24 2 abnormal chorion morphology 0.0230110432259358 0.104167370381283 0.841295212097266 0.681818181818182 24.2 24 2 increased myocardial infarction size 0.0230110432259358 0.104167370381283 0.841295212097266 0.681818181818182 24.2 24 2 abnormal blood-brain barrier function 0.0230110432259358 0.104167370381283 0.841295212097266 0.681818181818182 24.2 24 2 abnormal occipital bone morphology 0.0230110432259358 0.104167370381283 0.841295212097266 0.681818181818182 24.2 24 2 increased bone volume 0.0230110432259358 0.104167370381283 0.841295212097266 0.681818181818182 24.2 24 2 postnatal lethality, incomplete penetrance 8.6150848363985e-30 3.29692669700635e-27 0.840702750680297 0.681338028169014 24.2 24 2 reduced female fertility 5.36429787628513e-13 3.17706927791887e-11 0.84032820610635 0.681034482758621 24.2 24 2 short stride length 0.000768899678684494 0.00689238901163127 0.839051758198341 0.68 24.2 24 2 decreased oocyte number 0.000768899678684494 0.00689238901163127 0.839051758198341 0.68 24.2 24 2 abnormal keratinocyte physiology 0.0163257951155441 0.0832180642416312 0.839051758198341 0.68 24.2 24 2 decreased acute inflammation 0.0163257951155441 0.0832180642416312 0.839051758198341 0.68 24.2 24 2 increased rib number 2.98736135517341e-05 0.000428303249048637 0.838418989149925 0.67948717948718 24.2 24 2 increased urine protein level 2.98736135517341e-05 0.000428303249048637 0.838418989149925 0.67948717948718 24.2 24 2 impaired coordination 2.21194178142394e-18 3.33466980684367e-16 0.838053226694194 0.679190751445087 24.2 24 2 shortened head 0.0116407984570414 0.0626763769737892 0.837289044420613 0.678571428571429 24.2 24 2 abnormal bone mineralization 2.67422580414201e-07 6.42718520560701e-06 0.836196453236071 0.677685950413223 24.2 24 2 abnormal eyelid morphology 0.00833403371185141 0.0475479560968587 0.835867501051478 0.67741935483871 24.2 24 2 decreased thymus weight 0.00833403371185141 0.0475479560968587 0.835867501051478 0.67741935483871 24.2 24 2 abnormal CD8-positive, alpha beta T cell morphology 0.00833403371185141 0.0475479560968587 0.835867501051478 0.67741935483871 24.2 24 2 abnormal neuron morphology 3.46737522840459e-06 6.48503449673415e-05 0.835063395711361 0.676767676767677 24.2 24 2 abnormal oocyte morphology 0.00598674649646674 0.0367897867855604 0.834696818276896 0.676470588235294 24.2 24 2 abnormal endoderm development 0.00598674649646674 0.0367897867855604 0.834696818276896 0.676470588235294 24.2 24 2 perinatal lethality, complete penetrance 1.31862384712069e-11 6.51114176408132e-10 0.834185675093628 0.676056338028169 24.2 24 2 short snout 1.38444511824198e-06 2.77726389647332e-05 0.834024759647043 0.675925925925926 24.2 24 2 limb grasping 4.10021444019413e-10 1.59363803437233e-08 0.833899210232675 0.675824175824176 24.2 24 2 increased trabecular bone volume 0.00431280810082476 0.0279014568291329 0.833715975952246 0.675675675675676 24.2 24 2 abnormal pancreatic beta cell morphology 0.00311446746872884 0.0216101473597294 0.832882259976294 0.675 24.2 24 2 short tail 2.46961069400363e-05 0.000363500390611481 0.832510603456893 0.674698795180723 24.2 24 2 abnormal muscle physiology 1.33224554045464e-05 0.0002064773072823 0.831842456905162 0.674157303370786 24.2 24 2 abnormal locomotor behavior 9.79114346957918e-06 0.000160233351188015 0.831541064710632 0.673913043478261 24.2 24 2 abnormal inner ear morphology 0.00163399237407462 0.0125449260200945 0.831541064710632 0.673913043478261 24.2 24 2 abnormal sleep pattern 0.00163399237407462 0.0125449260200945 0.831541064710632 0.673913043478261 24.2 24 2 abnormal T cell differentiation 3.8951856948948e-06 7.15075602660576e-05 0.830744315047862 0.673267326732673 24.2 24 2 decreased body size 1.46782945289129e-38 8.1138350312602e-36 0.830330963719057 0.672932330827068 24.2 24 2 decreased bone mineral density 8.82863768762625e-14 6.36557572404936e-12 0.830330963719057 0.672932330827068 24.2 24 2 female infertility 8.82863768762625e-14 6.36557572404936e-12 0.830330963719057 0.672932330827068 24.2 24 2 abnormal lung morphology 6.2140930627319e-07 1.36189925053265e-05 0.829512365989462 0.672268907563025 24.2 24 2 abnormal lens morphology 2.48976737943311e-07 6.03169368612504e-06 0.829026323587515 0.671875 24.2 24 2 thick epidermis 0.000130546204036481 0.00151748167185251 0.828475475531975 0.671428571428571 24.2 24 2 abnormal seminiferous tubule morphology 4.01565342861229e-08 1.16150440740384e-06 0.82823400789119 0.671232876712329 24.2 24 2 enlarged liver 5.91743310351404e-06 0.000100819279760214 0.826712761754247 0.67 24.2 24 2 male infertility 3.80361294000294e-24 9.46148718825732e-22 0.826688230946207 0.669980119284294 24.2 24 2 abnormal eye morphology 1.11525107627008e-07 2.9991211375371e-06 0.82555875489257 0.669064748201439 24.2 24 2 increased heart weight 1.11525107627008e-07 2.9991211375371e-06 0.82555875489257 0.669064748201439 24.2 24 2 perinatal lethality, incomplete penetrance 1.71671863748925e-11 8.29191769078545e-10 0.824419673919504 0.668141592920354 24.2 24 2 abnormal kidney physiology 0.00181527647146841 0.0137877869397791 0.82259976293955 0.666666666666667 24.2 24 2 abnormal lymph node morphology 0.00181527647146841 0.0137877869397791 0.82259976293955 0.666666666666667 24.2 24 2 enhanced paired-pulse facilitation 0.0129061886147368 0.0686719661586264 0.82259976293955 0.666666666666667 24.2 24 2 abnormal foregut morphology 0.0254683310143815 0.113738731415213 0.82259976293955 0.666666666666667 24.2 24 2 abnormal adrenal gland morphology 0.0254683310143815 0.113738731415213 0.82259976293955 0.666666666666667 24.2 24 2 blindness 0.0254683310143815 0.113738731415213 0.82259976293955 0.666666666666667 24.2 24 2 vagina atresia 0.0742280354385711 0.248509068847168 0.82259976293955 0.666666666666667 24.2 24 2 abnormal prostate gland morphology 0.0742280354385711 0.248509068847168 0.82259976293955 0.666666666666667 24.2 24 2 hyperpigmentation 0.0742280354385711 0.248509068847168 0.82259976293955 0.666666666666667 24.2 24 2 audiogenic seizures 0.0742280354385711 0.248509068847168 0.82259976293955 0.666666666666667 24.2 24 2 abnormal seizure response to electrical stimulation 0.0742280354385711 0.248509068847168 0.82259976293955 0.666666666666667 24.2 24 2 absent egg cylinders 0.0742280354385711 0.248509068847168 0.82259976293955 0.666666666666667 24.2 24 2 placental labyrinth hypoplasia 0.0742280354385711 0.248509068847168 0.82259976293955 0.666666666666667 24.2 24 2 abnormal ear development 0.0742280354385711 0.248509068847168 0.82259976293955 0.666666666666667 24.2 24 2 abnormal olfactory nerve morphology 0.0742280354385711 0.248509068847168 0.82259976293955 0.666666666666667 24.2 24 2 abnormal neurotransmitter secretion 0.0742280354385711 0.248509068847168 0.82259976293955 0.666666666666667 24.2 24 2 abnormal dendritic cell morphology 0.0742280354385711 0.248509068847168 0.82259976293955 0.666666666666667 24.2 24 2 abnormal cerebral aqueduct morphology 0.0742280354385711 0.248509068847168 0.82259976293955 0.666666666666667 24.2 24 2 bicuspid aortic valve 0.0742280354385711 0.248509068847168 0.82259976293955 0.666666666666667 24.2 24 2 abnormal microglial cell activation 0.0742280354385711 0.248509068847168 0.82259976293955 0.666666666666667 24.2 24 2 decreased trabecular bone mass 0.0742280354385711 0.248509068847168 0.82259976293955 0.666666666666667 24.2 24 2 mesocardia 0.108545168430039 0.318215800200025 0.82259976293955 0.666666666666667 24.2 24 2 abnormal mating frequency 0.108545168430039 0.318215800200025 0.82259976293955 0.666666666666667 24.2 24 2 abnormal respiratory function 0.108545168430039 0.318215800200025 0.82259976293955 0.666666666666667 24.2 24 2 abnormal corticospinal tract morphology 0.108545168430039 0.318215800200025 0.82259976293955 0.666666666666667 24.2 24 2 abnormal gastrocnemius morphology 0.108545168430039 0.318215800200025 0.82259976293955 0.666666666666667 24.2 24 2 abnormal aorta elastic fiber morphology 0.108545168430039 0.318215800200025 0.82259976293955 0.666666666666667 24.2 24 2 loss of dopaminergic neurons 0.108545168430039 0.318215800200025 0.82259976293955 0.666666666666667 24.2 24 2 decreased circulating ketone body level 0.108545168430039 0.318215800200025 0.82259976293955 0.666666666666667 24.2 24 2 absent ovary 0.108545168430039 0.318215800200025 0.82259976293955 0.666666666666667 24.2 24 2 stria vascularis degeneration 0.108545168430039 0.318215800200025 0.82259976293955 0.666666666666667 24.2 24 2 abnormal fatty acid level 0.108545168430039 0.318215800200025 0.82259976293955 0.666666666666667 24.2 24 2 abnormal somatic nervous system physiology 0.108545168430039 0.318215800200025 0.82259976293955 0.666666666666667 24.2 24 2 decreased prostaglandin level 0.108545168430039 0.318215800200025 0.82259976293955 0.666666666666667 24.2 24 2 increased skeletal muscle glycogen level 0.108545168430039 0.318215800200025 0.82259976293955 0.666666666666667 24.2 24 2 persistent right dorsal aorta 0.108545168430039 0.318215800200025 0.82259976293955 0.666666666666667 24.2 24 2 decreased startle reflex 1.42179322375681e-06 2.82936851527606e-05 0.82259976293955 0.666666666666667 24.2 24 2 abnormal sternum morphology 0.000198374722034403 0.00218827991601143 0.82259976293955 0.666666666666667 24.2 24 2 abnormal skin morphology 0.000271349703041839 0.00284681670744421 0.82259976293955 0.666666666666667 24.2 24 2 increased macrophage cell number 0.000698239987074836 0.00631589806490419 0.82259976293955 0.666666666666667 24.2 24 2 abnormal response to novel object 0.00131838165535749 0.0105960399602642 0.82259976293955 0.666666666666667 24.2 24 2 impaired wound healing 0.00664411139880825 0.0400660051019043 0.82259976293955 0.666666666666667 24.2 24 2 narrow eye opening 0.00664411139880825 0.0400660051019043 0.82259976293955 0.666666666666667 24.2 24 2 abnormal retinal blood vessel morphology 0.00664411139880825 0.0400660051019043 0.82259976293955 0.666666666666667 24.2 24 2 abnormal epidermis stratum basale morphology 0.00924512829414527 0.0513905176127069 0.82259976293955 0.666666666666667 24.2 24 2 thin epidermis 0.0180871614262752 0.0848102055567568 0.82259976293955 0.666666666666667 24.2 24 2 abnormal fetal cardiomyocyte proliferation 0.0180871614262752 0.0848102055567568 0.82259976293955 0.666666666666667 24.2 24 2 thick interventricular septum 0.0180871614262752 0.0848102055567568 0.82259976293955 0.666666666666667 24.2 24 2 abnormal Peyer's patch follicle morphology 0.0514857941078671 0.189034557702316 0.82259976293955 0.666666666666667 24.2 24 2 abnormal white adipose tissue morphology 0.0514857941078671 0.189034557702316 0.82259976293955 0.666666666666667 24.2 24 2 abnormal metacarpal bone morphology 0.0514857941078671 0.189034557702316 0.82259976293955 0.666666666666667 24.2 24 2 absent allantois 0.0514857941078671 0.189034557702316 0.82259976293955 0.666666666666667 24.2 24 2 increased circulating renin level 0.0514857941078671 0.189034557702316 0.82259976293955 0.666666666666667 24.2 24 2 abnormal macrophage chemotaxis 0.0514857941078671 0.189034557702316 0.82259976293955 0.666666666666667 24.2 24 2 increased adipocyte glucose uptake 0.0514857941078671 0.189034557702316 0.82259976293955 0.666666666666667 24.2 24 2 crypts of Lieberkuhn abscesses 0.162174544864764 0.423082517410697 0.82259976293955 0.666666666666667 24.2 24 2 abnormal geniculate ganglion morphology 0.162174544864764 0.423082517410697 0.82259976293955 0.666666666666667 24.2 24 2 wavy vibrissae 0.162174544864764 0.423082517410697 0.82259976293955 0.666666666666667 24.2 24 2 abnormal lung volume 0.162174544864764 0.423082517410697 0.82259976293955 0.666666666666667 24.2 24 2 decreased fear-related response 0.162174544864764 0.423082517410697 0.82259976293955 0.666666666666667 24.2 24 2 decreased vestibular hair cell number 0.162174544864764 0.423082517410697 0.82259976293955 0.666666666666667 24.2 24 2 short frontal bone 0.162174544864764 0.423082517410697 0.82259976293955 0.666666666666667 24.2 24 2 decreased cochlear hair cell number 0.162174544864764 0.423082517410697 0.82259976293955 0.666666666666667 24.2 24 2 abnormal gallbladder physiology 0.162174544864764 0.423082517410697 0.82259976293955 0.666666666666667 24.2 24 2 increased tidal volume 0.162174544864764 0.423082517410697 0.82259976293955 0.666666666666667 24.2 24 2 absent cervical lymph nodes 0.162174544864764 0.423082517410697 0.82259976293955 0.666666666666667 24.2 24 2 abnormal optic chiasm morphology 0.162174544864764 0.423082517410697 0.82259976293955 0.666666666666667 24.2 24 2 iris coloboma 0.162174544864764 0.423082517410697 0.82259976293955 0.666666666666667 24.2 24 2 decreased airway resistance 0.162174544864764 0.423082517410697 0.82259976293955 0.666666666666667 24.2 24 2 increased myeloid cell number 0.162174544864764 0.423082517410697 0.82259976293955 0.666666666666667 24.2 24 2 symmetric azygos veins 0.162174544864764 0.423082517410697 0.82259976293955 0.666666666666667 24.2 24 2 increased endoplasmic reticulum stress 0.162174544864764 0.423082517410697 0.82259976293955 0.666666666666667 24.2 24 2 decreased circulating glucose level 1.13024305046588e-13 7.59859348117261e-12 0.82259976293955 0.666666666666667 24.2 24 2 decreased grip strength 4.72233686584956e-11 2.13578417341832e-09 0.82259976293955 0.666666666666667 24.2 24 2 hypoglycemia 1.65655949146254e-05 0.000251261691159334 0.82259976293955 0.666666666666667 24.2 24 2 decreased heart weight 5.70689657659822e-05 0.000751106097052279 0.82259976293955 0.666666666666667 24.2 24 2 lethality at weaning, complete penetrance 0.00250340689866215 0.0177920704583489 0.82259976293955 0.666666666666667 24.2 24 2 disheveled coat 0.003458586770939 0.0235382615395643 0.82259976293955 0.666666666666667 24.2 24 2 spina bifida 0.003458586770939 0.0235382615395643 0.82259976293955 0.666666666666667 24.2 24 2 abnormal iris morphology 0.00478801188875138 0.0299627159075951 0.82259976293955 0.666666666666667 24.2 24 2 abnormal scapula morphology 0.0360742214327919 0.148813641482703 0.82259976293955 0.666666666666667 24.2 24 2 abnormal embryonic/fetal subventricular zone morphology 0.0360742214327919 0.148813641482703 0.82259976293955 0.666666666666667 24.2 24 2 abnormal glucose homeostasis 2.6656617282862e-09 9.47261935587419e-08 0.820339873480924 0.664835164835165 24.2 24 2 enlarged heart 2.34496610803693e-11 1.08020429513738e-09 0.819054074306189 0.663793103448276 24.2 24 2 abnormal pulmonary alveolus morphology 9.90245005579315e-06 0.000160471299764075 0.818527486885394 0.663366336633663 24.2 24 2 anophthalmia 3.39683280308747e-05 0.0004681897503256 0.817978415956743 0.662921348314607 24.2 24 2 abnormal intestine morphology 0.000160293539060095 0.00180420895209044 0.817041656433201 0.662162162162162 24.2 24 2 increased blood urea nitrogen level 1.51828080768893e-07 3.95468430274996e-06 0.816926661126173 0.662068965517241 24.2 24 2 abnormal ovary morphology 0.000219020071445302 0.00237853121880003 0.816806806862511 0.661971830985915 24.2 24 2 atelectasis 0.000219020071445302 0.00237853121880003 0.816806806862511 0.661971830985915 24.2 24 2 abnormal CD4-positive, alpha-beta T cell physiology 0.000219020071445302 0.00237853121880003 0.816806806862511 0.661971830985915 24.2 24 2 cataract 1.73698691606437e-06 3.42917059818263e-05 0.815801417791289 0.661157024793388 24.2 24 2 no abnormal phenotype detected 5.12037299275234e-75 1.27369278194714e-71 0.815013828526274 0.660518731988473 24.2 24 2 abnormal coat/ hair morphology 0.00145152943927115 0.0114989792362643 0.814839387817478 0.660377358490566 24.2 24 2 enlarged kidney 0.00145152943927115 0.0114989792362643 0.814839387817478 0.660377358490566 24.2 24 2 increased circulating glucose level 3.07005196537367e-07 7.34303294602597e-06 0.813848701631682 0.659574468085106 24.2 24 2 increased respiratory quotient 0.00275222349123369 0.0193121465005467 0.813848701631682 0.659574468085106 24.2 24 2 small ovary 3.73703335553475e-05 0.000507971064037852 0.813560205105049 0.659340659340659 24.2 24 2 palatal shelves fail to meet at midline 0.0052537775019128 0.032836109386955 0.812568058513457 0.658536585365854 24.2 24 2 decreased percent body fat/body weight 0.000240296092490194 0.00257090980674992 0.811331273036268 0.657534246575342 24.2 24 2 decreased glycogen level 0.0101176195507598 0.0560525136581626 0.810848337754699 0.657142857142857 24.2 24 2 cleft palate 1.13681249113249e-06 2.35651755974339e-05 0.810040987932839 0.656488549618321 24.2 24 2 abnormal spatial learning 5.97827021822823e-08 1.68033301331556e-06 0.809983202158268 0.656441717791411 24.2 24 2 abnormal vertebral body morphology 0.014099719678039 0.0738192894313789 0.809746641643619 0.65625 24.2 24 2 abnormal crypts of Lieberkuhn morphology 0.014099719678039 0.0738192894313789 0.809746641643619 0.65625 24.2 24 2 decreased susceptibility to parasitic infection 0.014099719678039 0.0738192894313789 0.809746641643619 0.65625 24.2 24 2 abnormal auditory brainstem response waveform shape 0.014099719678039 0.0738192894313789 0.809746641643619 0.65625 24.2 24 2 lethargy 4.09165425922513e-05 0.000553151628794702 0.809332024827621 0.655913978494624 24.2 24 2 abnormal long bone morphology 0.000842069706312394 0.00744102449183688 0.809114520924147 0.655737704918033 24.2 24 2 respiratory failure 2.00876446386787e-07 5.12492472191931e-06 0.808980561566378 0.655629139072848 24.2 24 2 dermatitis 0.00115473275791283 0.00944867676088209 0.808417008406109 0.655172413793103 24.2 24 2 enlarged epididymis 0.0197178463048271 0.0909414416594705 0.808417008406109 0.655172413793103 24.2 24 2 arrest of spermatogenesis 0.000103328313025701 0.00125684003013704 0.807910481458486 0.654761904761905 24.2 24 2 increased circulating calcium level 0.00158522002834866 0.0123226088141166 0.807643403613376 0.654545454545455 24.2 24 2 abnormal skeleton development 0.000140844799890381 0.00160186962395167 0.807366433996225 0.654320987654321 24.2 24 2 infertility 1.30698442082604e-05 0.000203195234175298 0.807224066436007 0.654205607476635 24.2 24 2 abnormal nerve conduction 0.0276906231164817 0.120842850881137 0.806780536729174 0.653846153846154 24.2 24 2 neonatal lethality, incomplete penetrance 1.48453242993606e-11 7.24073415581561e-10 0.806780536729174 0.653846153846154 24.2 24 2 abnormal gait 1.94537399895679e-13 1.24079944164231e-11 0.806626952008685 0.653721682847896 24.2 24 2 decreased circulating creatinine level 0.00299878438624767 0.0208656675826324 0.805812012675477 0.653061224489796 24.2 24 2 abnormal neuromuscular synapse morphology 0.00035792025374276 0.00357560896058279 0.805462267878309 0.652777777777778 24.2 24 2 hypoactivity 6.73119592199965e-16 6.97660410665589e-14 0.805144065052238 0.652519893899204 24.2 24 2 abnormal pulmonary artery morphology 0.0390878228945293 0.155917380808581 0.804717159397385 0.652173913043478 24.2 24 2 bidirectional circling 0.0390878228945293 0.155917380808581 0.804717159397385 0.652173913043478 24.2 24 2 conjunctivitis 0.0390878228945293 0.155917380808581 0.804717159397385 0.652173913043478 24.2 24 2 pancreas inflammation 0.0390878228945293 0.155917380808581 0.804717159397385 0.652173913043478 24.2 24 2 abnormal sacral vertebrae morphology 0.0390878228945293 0.155917380808581 0.804717159397385 0.652173913043478 24.2 24 2 dilated heart 0.0390878228945293 0.155917380808581 0.804717159397385 0.652173913043478 24.2 24 2 abnormal ulna morphology 0.0390878228945293 0.155917380808581 0.804717159397385 0.652173913043478 24.2 24 2 abnormal hepatocyte physiology 0.0390878228945293 0.155917380808581 0.804717159397385 0.652173913043478 24.2 24 2 reduced male fertility 4.05367844078802e-10 1.58795671204098e-08 0.804480825429868 0.651982378854626 24.2 24 2 abnormal renal glomerulus morphology 1.42231342332239e-05 0.000218395348179904 0.803732795899652 0.651376146788991 24.2 24 2 decreased oxygen consumption 0.00570748676545905 0.035272977215104 0.803469535894444 0.651162790697674 24.2 24 2 cyanosis 1.0203529474032e-08 3.21282019831071e-07 0.803320080995654 0.651041666666667 24.2 24 2 increased or absent threshold for auditory brainstem response 2.54511971410574e-12 1.36150221265334e-10 0.80267520120745 0.650519031141868 24.2 24 2 epidermal hyperplasia 0.00125359392761427 0.0101905715520931 0.802034768866061 0.65 24.2 24 2 abnormal eating behavior 0.00125359392761427 0.0101905715520931 0.802034768866061 0.65 24.2 24 2 abnormal long bone epiphyseal plate morphology 0.00125359392761427 0.0101905715520931 0.802034768866061 0.65 24.2 24 2 abnormal incisor morphology 0.00125359392761427 0.0101905715520931 0.802034768866061 0.65 24.2 24 2 abnormal posture 0.000208613580179695 0.00228099464042634 0.802034768866061 0.65 24.2 24 2 abnormal retinal pigment epithelium morphology 0.000208613580179695 0.00228099464042634 0.802034768866061 0.65 24.2 24 2 abnormal pericardium morphology 0.0555333892856465 0.202253742090843 0.802034768866061 0.65 24.2 24 2 abnormal lens epithelium morphology 0.0555333892856465 0.202253742090843 0.802034768866061 0.65 24.2 24 2 dilated vasculature 0.0555333892856465 0.202253742090843 0.802034768866061 0.65 24.2 24 2 abnormal response to tactile stimuli 0.0555333892856465 0.202253742090843 0.802034768866061 0.65 24.2 24 2 abnormal blood homeostasis 1.13693948867488e-05 0.000181873760648151 0.80095240075693 0.649122807017544 24.2 24 2 abnormal hair follicle development 0.0109480559489315 0.0592672234449775 0.800367336914156 0.648648648648649 24.2 24 2 increased circulating triglyceride level 8.68168126193006e-07 1.83793039481285e-05 0.799907355686045 0.648275862068965 24.2 24 2 abnormal maxilla morphology 0.00235909946871688 0.0169833323595992 0.799749769524562 0.648148148148148 24.2 24 2 impaired limb coordination 0.00235909946871688 0.0169833323595992 0.799749769524562 0.648148148148148 24.2 24 2 increased circulating free fatty acid level 0.000529600512087035 0.00496188803697364 0.799427938631393 0.647887323943662 24.2 24 2 postnatal lethality, complete penetrance 1.48504401578315e-15 1.44864587814141e-13 0.799157800783241 0.647668393782383 24.2 24 2 distended abdomen 0.00324183449692926 0.0223265330840665 0.798405652264857 0.647058823529412 24.2 24 2 abnormal cervical vertebrae morphology 0.00324183449692926 0.0223265330840665 0.798405652264857 0.647058823529412 24.2 24 2 abnormal dendritic spine morphology 0.00324183449692926 0.0223265330840665 0.798405652264857 0.647058823529412 24.2 24 2 impaired synaptic plasticity 0.0152188282565559 0.0782166018350883 0.798405652264857 0.647058823529412 24.2 24 2 increased width of hypertrophic chondrocyte zone 0.0152188282565559 0.0782166018350883 0.798405652264857 0.647058823529412 24.2 24 2 abnormal nervous system development 0.0152188282565559 0.0782166018350883 0.798405652264857 0.647058823529412 24.2 24 2 decreased osteoblast cell number 0.0152188282565559 0.0782166018350883 0.798405652264857 0.647058823529412 24.2 24 2 abnormal involuntary movement 0.0795590189070699 0.265820093393333 0.798405652264857 0.647058823529412 24.2 24 2 coloboma 0.0795590189070699 0.265820093393333 0.798405652264857 0.647058823529412 24.2 24 2 abnormal survival 0.0795590189070699 0.265820093393333 0.798405652264857 0.647058823529412 24.2 24 2 abnormal motor coordination/ balance 5.2342458436192e-05 0.000696266659679292 0.797672497395927 0.646464646464647 24.2 24 2 retinal degeneration 7.10905960333687e-05 0.000906860808374383 0.796893520347689 0.645833333333333 24.2 24 2 small cranium 0.021219197529074 0.0972058082017892 0.796064286715693 0.645161290322581 24.2 24 2 increased susceptibility to parasitic infection 0.000131255960398391 0.00151748167185251 0.795179770841565 0.644444444444444 24.2 24 2 albuminuria 0.00614713108697045 0.0373862801438606 0.795179770841565 0.644444444444444 24.2 24 2 decreased osteoclast cell number 0.00614713108697045 0.0373862801438606 0.795179770841565 0.644444444444444 24.2 24 2 abnormal colon morphology 0.00185158089286435 0.014042095948171 0.794715025212785 0.644067796610169 24.2 24 2 insulin resistance 4.24913990324872e-06 7.71513540827095e-05 0.794556589202974 0.643939393939394 24.2 24 2 abnormal retina morphology 8.92413380409054e-09 2.86435907582906e-07 0.793221199977423 0.642857142857143 24.2 24 2 abnormal renal tubule epithelium morphology 0.0296906147708959 0.128555969090694 0.793221199977423 0.642857142857143 24.2 24 2 abnormal fluid regulation 0.11526310724751 0.336324902379098 0.793221199977423 0.642857142857143 24.2 24 2 amyloid beta deposits 0.11526310724751 0.336324902379098 0.793221199977423 0.642857142857143 24.2 24 2 abnormal positive T cell selection 0.11526310724751 0.336324902379098 0.793221199977423 0.642857142857143 24.2 24 2 abnormal iris pigmentation 0.11526310724751 0.336324902379098 0.793221199977423 0.642857142857143 24.2 24 2 increased lung compliance 0.11526310724751 0.336324902379098 0.793221199977423 0.642857142857143 24.2 24 2 decreased compact bone area 0.11526310724751 0.336324902379098 0.793221199977423 0.642857142857143 24.2 24 2 neonatal lethality, complete penetrance 2.84409160665902e-17 3.72351466924437e-15 0.792834639938447 0.642543859649123 24.2 24 2 rib fusion 0.00106231823701008 0.00881412477242968 0.791905741934343 0.641791044776119 24.2 24 2 respiratory distress 2.0753153004342e-07 5.26770082635722e-06 0.79169283543026 0.641618497109827 24.2 24 2 abnormal placenta development 0.00348032461267113 0.0236427652485323 0.791558262451265 0.641509433962264 24.2 24 2 increased vascular permeability 0.0117344504457824 0.0630441587124916 0.790961310518798 0.641025641025641 24.2 24 2 decreased trabecular bone volume 0.0117344504457824 0.0630441587124916 0.790961310518798 0.641025641025641 24.2 24 2 abnormal tooth morphology 0.0014509364625991 0.0114989792362643 0.790466959699723 0.640625 24.2 24 2 microphthalmia 1.16850988088235e-06 2.41217288688369e-05 0.790340948706626 0.640522875816993 24.2 24 2 weight loss 2.22598109868263e-07 5.53712798297305e-06 0.789695772421968 0.64 24.2 24 2 testicular atrophy 0.00477929464775901 0.0299458323332507 0.789695772421968 0.64 24.2 24 2 abnormal axon extension 0.00477929464775901 0.0299458323332507 0.789695772421968 0.64 24.2 24 2 abnormal inner ear vestibule morphology 0.0417217281678701 0.160035156233735 0.789695772421968 0.64 24.2 24 2 increased liver glycogen level 0.0417217281678701 0.160035156233735 0.789695772421968 0.64 24.2 24 2 abnormal uterus morphology 0.0162630570503665 0.0830684895539769 0.788324772817068 0.638888888888889 24.2 24 2 postnatal lethality 5.45699939790913e-07 1.21742475356941e-05 0.787911821128846 0.63855421686747 24.2 24 2 abnormal enzyme/coenzyme level 0.00271255564643804 0.0190606840974989 0.787142876605948 0.637931034482759 24.2 24 2 impaired balance 8.77207081020874e-05 0.00108788635029479 0.786308596927511 0.637254901960784 24.2 24 2 decreased circulating calcium level 0.00371338848936128 0.0246650303532341 0.785208864624116 0.636363636363636 24.2 24 2 abnormal joint morphology 0.00371338848936128 0.0246650303532341 0.785208864624116 0.636363636363636 24.2 24 2 dextrocardia 0.022595254599853 0.102846652913329 0.785208864624116 0.636363636363636 24.2 24 2 abnormal locomotor coordination 0.022595254599853 0.102846652913329 0.785208864624116 0.636363636363636 24.2 24 2 abnormal QRS complex 0.022595254599853 0.102846652913329 0.785208864624116 0.636363636363636 24.2 24 2 increased osteoblast cell number 0.022595254599853 0.102846652913329 0.785208864624116 0.636363636363636 24.2 24 2 teratozoospermia 0.000277696170820366 0.00287818085872871 0.785208864624115 0.636363636363636 24.2 24 2 omphalocele 0.00904742037073957 0.0504041616398985 0.785208864624115 0.636363636363636 24.2 24 2 abnormal cochlear sensory epithelium morphology 0.0589347832947903 0.211718614261088 0.785208864624115 0.636363636363636 24.2 24 2 parakeratosis 0.0589347832947903 0.211718614261088 0.785208864624115 0.636363636363636 24.2 24 2 abnormal sperm midpiece morphology 0.0589347832947903 0.211718614261088 0.785208864624115 0.636363636363636 24.2 24 2 increased circulating creatine kinase level 0.0589347832947903 0.211718614261088 0.785208864624115 0.636363636363636 24.2 24 2 rough coat 0.0589347832947903 0.211718614261088 0.785208864624115 0.636363636363636 24.2 24 2 abnormal ear position 0.169662138014343 0.436211440114396 0.785208864624115 0.636363636363636 24.2 24 2 premature suture closure 0.169662138014343 0.436211440114396 0.785208864624115 0.636363636363636 24.2 24 2 abnormal stomach epithelium morphology 0.169662138014343 0.436211440114396 0.785208864624115 0.636363636363636 24.2 24 2 abnormal large intestine morphology 0.169662138014343 0.436211440114396 0.785208864624115 0.636363636363636 24.2 24 2 abnormal sebaceous gland morphology 0.169662138014343 0.436211440114396 0.785208864624115 0.636363636363636 24.2 24 2 abnormal enteric ganglia morphology 0.169662138014343 0.436211440114396 0.785208864624115 0.636363636363636 24.2 24 2 failure of somite differentiation 0.169662138014343 0.436211440114396 0.785208864624115 0.636363636363636 24.2 24 2 abnormal fear/anxiety-related behavior 0.169662138014343 0.436211440114396 0.785208864624115 0.636363636363636 24.2 24 2 abnormal bronchiole morphology 0.169662138014343 0.436211440114396 0.785208864624115 0.636363636363636 24.2 24 2 abnormal vestibular ganglion morphology 0.169662138014343 0.436211440114396 0.785208864624115 0.636363636363636 24.2 24 2 fatigue 0.169662138014343 0.436211440114396 0.785208864624115 0.636363636363636 24.2 24 2 decreased post-tetanic potentiation 0.169662138014343 0.436211440114396 0.785208864624115 0.636363636363636 24.2 24 2 retinal detachment 0.169662138014343 0.436211440114396 0.785208864624115 0.636363636363636 24.2 24 2 fused joints 0.169662138014343 0.436211440114396 0.785208864624115 0.636363636363636 24.2 24 2 abnormal frequency of paradoxical sleep 0.169662138014343 0.436211440114396 0.785208864624115 0.636363636363636 24.2 24 2 impaired luteinization 0.169662138014343 0.436211440114396 0.785208864624115 0.636363636363636 24.2 24 2 abnormal nerve fiber response 0.169662138014343 0.436211440114396 0.785208864624115 0.636363636363636 24.2 24 2 pulmonary hypertension 0.169662138014343 0.436211440114396 0.785208864624115 0.636363636363636 24.2 24 2 abnormal spinal cord ventral horn morphology 0.169662138014343 0.436211440114396 0.785208864624115 0.636363636363636 24.2 24 2 abnormal palate development 0.169662138014343 0.436211440114396 0.785208864624115 0.636363636363636 24.2 24 2 palatal shelf hypoplasia 0.169662138014343 0.436211440114396 0.785208864624115 0.636363636363636 24.2 24 2 increased subcutaneous adipose tissue amount 0.169662138014343 0.436211440114396 0.785208864624115 0.636363636363636 24.2 24 2 decreased core body temperature 0.169662138014343 0.436211440114396 0.785208864624115 0.636363636363636 24.2 24 2 abnormal brain ependyma motile cilium morphology 0.169662138014343 0.436211440114396 0.785208864624115 0.636363636363636 24.2 24 2 increased pancreatic beta cell proliferation 0.169662138014343 0.436211440114396 0.785208864624115 0.636363636363636 24.2 24 2 abnormal phrenic nerve innervation pattern to diaphragm 0.169662138014343 0.436211440114396 0.785208864624115 0.636363636363636 24.2 24 2 abnormal cranium morphology 1.01708240456907e-05 0.000163753558664438 0.78269753563278 0.634328358208955 24.2 24 2 scaly skin 0.0124759150723383 0.0664536161508384 0.782472945235181 0.634146341463415 24.2 24 2 arrested T cell differentiation 0.0314834368604377 0.135845705447248 0.781469774792572 0.633333333333333 24.2 24 2 abnormal synaptic transmission 0.0314834368604377 0.135845705447248 0.781469774792572 0.633333333333333 24.2 24 2 increased circulating LDL cholesterol level 0.00697864483551829 0.0420323947417718 0.780630387279369 0.63265306122449 24.2 24 2 alopecia 0.000231543828956251 0.0024933561667908 0.77930503857431 0.631578947368421 24.2 24 2 abnormal axial skeleton morphology 0.000943088864423757 0.00807550275474732 0.77930503857431 0.631578947368421 24.2 24 2 abnormal frontal bone morphology 0.0172334000609576 0.0843723760424559 0.77930503857431 0.631578947368421 24.2 24 2 increased grooming behavior 0.0172334000609576 0.0843723760424559 0.77930503857431 0.631578947368421 24.2 24 2 shiny skin 0.0837944514626644 0.270948434330732 0.77930503857431 0.631578947368421 24.2 24 2 abnormal neural crest cell migration 0.0837944514626644 0.270948434330732 0.77930503857431 0.631578947368421 24.2 24 2 abnormal metatarsal bone morphology 0.0837944514626644 0.270948434330732 0.77930503857431 0.631578947368421 24.2 24 2 increased susceptibility to ischemic brain injury 0.0837944514626644 0.270948434330732 0.77930503857431 0.631578947368421 24.2 24 2 increased left ventricle weight 0.0837944514626644 0.270948434330732 0.77930503857431 0.631578947368421 24.2 24 2 diluted coat color 0.00538640735739339 0.0333715773387697 0.776899776109575 0.62962962962963 24.2 24 2 abnormal small intestine morphology 0.00538640735739339 0.0333715773387697 0.776899776109575 0.62962962962963 24.2 24 2 abnormal heart valve morphology 0.044016507989833 0.168318314565272 0.776899776109575 0.62962962962963 24.2 24 2 increased startle reflex 0.000424029173304312 0.00412020534607217 0.776386293111485 0.629213483146067 24.2 24 2 abnormal motor capabilities/coordination/movement 2.07845541927456e-05 0.000309590290745238 0.775861140045257 0.628787878787879 24.2 24 2 ovary cysts 0.0238516429894416 0.10748362669608 0.775594062200147 0.628571428571429 24.2 24 2 abnormal intestinal goblet cell morphology 0.0238516429894416 0.10748362669608 0.775594062200147 0.628571428571429 24.2 24 2 impaired adaptive thermogenesis 0.0238516429894416 0.10748362669608 0.775594062200147 0.628571428571429 24.2 24 2 decreased bone mineralization 0.0238516429894416 0.10748362669608 0.775594062200147 0.628571428571429 24.2 24 2 abnormal cornea morphology 0.000997466092366676 0.00851182471616503 0.775142084308422 0.628205128205128 24.2 24 2 absent gastric milk in neonates 0.000997466092366676 0.00851182471616503 0.775142084308422 0.628205128205128 24.2 24 2 abnormal male reproductive system morphology 0.0131723782807641 0.070013442250856 0.774774195326785 0.627906976744186 24.2 24 2 decreased compact bone thickness 0.00236571845732708 0.0169833323595992 0.773489329331218 0.626865671641791 24.2 24 2 maternal effect 0.00236571845732708 0.0169833323595992 0.773489329331218 0.626865671641791 24.2 24 2 decreased anxiety-related response 5.06704828556468e-05 0.000675832847739525 0.772441240809089 0.626016260162602 24.2 24 2 decreased cardiac muscle contractility 0.000202136943998378 0.00221993663662678 0.771187277755828 0.625 24.2 24 2 cachexia 0.000202136943998378 0.00221993663662678 0.771187277755828 0.625 24.2 24 2 abnormal sensory capabilities/reflexes/nociception 0.0617869760281092 0.221144032906362 0.771187277755828 0.625 24.2 24 2 increased circulating total protein level 0.0617869760281092 0.221144032906362 0.771187277755828 0.625 24.2 24 2 abnormal lung saccule morphology 0.0617869760281092 0.221144032906362 0.771187277755828 0.625 24.2 24 2 increased sensitivity to induced morbidity/mortality 9.31233779584897e-07 1.95480508583749e-05 0.771187277755828 0.625 24.2 24 2 kidney cortex cysts 0.0330849939474656 0.141285703767074 0.771187277755828 0.625 24.2 24 2 increased circulating follicle stimulating hormone level 0.0330849939474656 0.141285703767074 0.771187277755828 0.625 24.2 24 2 abnormal depression-related behavior 0.0330849939474656 0.141285703767074 0.771187277755828 0.625 24.2 24 2 vasculature congestion 0.120144258627419 0.346905215711788 0.771187277755828 0.625 24.2 24 2 delayed hair appearance 0.120144258627419 0.346905215711788 0.771187277755828 0.625 24.2 24 2 abnormal mouth morphology 0.120144258627419 0.346905215711788 0.771187277755828 0.625 24.2 24 2 disorganized retinal layers 0.120144258627419 0.346905215711788 0.771187277755828 0.625 24.2 24 2 reduced male mating frequency 0.120144258627419 0.346905215711788 0.771187277755828 0.625 24.2 24 2 increased pancreatic beta cell number 0.120144258627419 0.346905215711788 0.771187277755828 0.625 24.2 24 2 abnormal molar crown morphology 0.120144258627419 0.346905215711788 0.771187277755828 0.625 24.2 24 2 bowed radius 0.120144258627419 0.346905215711788 0.771187277755828 0.625 24.2 24 2 increased thymus weight 0.120144258627419 0.346905215711788 0.771187277755828 0.625 24.2 24 2 abnormal wound healing 0.120144258627419 0.346905215711788 0.771187277755828 0.625 24.2 24 2 abnormal level of surface class II molecules 0.120144258627419 0.346905215711788 0.771187277755828 0.625 24.2 24 2 abnormal Langerhans cell physiology 0.120144258627419 0.346905215711788 0.771187277755828 0.625 24.2 24 2 loose skin 0.120144258627419 0.346905215711788 0.771187277755828 0.625 24.2 24 2 impaired somite development 0.120144258627419 0.346905215711788 0.771187277755828 0.625 24.2 24 2 increased heart left ventricle size 0.120144258627419 0.346905215711788 0.771187277755828 0.625 24.2 24 2 absent pre-B cells 0.25588116604667 0.501311364021673 0.771187277755828 0.625 24.2 24 2 abnormal esophageal epithelium morphology 0.25588116604667 0.501311364021673 0.771187277755828 0.625 24.2 24 2 abnormal cecum morphology 0.25588116604667 0.501311364021673 0.771187277755828 0.625 24.2 24 2 abnormal vagus ganglion morphology 0.25588116604667 0.501311364021673 0.771187277755828 0.625 24.2 24 2 dermal cysts 0.25588116604667 0.501311364021673 0.771187277755828 0.625 24.2 24 2 absent eyelids 0.25588116604667 0.501311364021673 0.771187277755828 0.625 24.2 24 2 unidirectional circling 0.25588116604667 0.501311364021673 0.771187277755828 0.625 24.2 24 2 spinning 0.25588116604667 0.501311364021673 0.771187277755828 0.625 24.2 24 2 abnormal drinking behavior 0.25588116604667 0.501311364021673 0.771187277755828 0.625 24.2 24 2 poor grooming 0.25588116604667 0.501311364021673 0.771187277755828 0.625 24.2 24 2 preneoplasia 0.25588116604667 0.501311364021673 0.771187277755828 0.625 24.2 24 2 abnormal parturition 0.25588116604667 0.501311364021673 0.771187277755828 0.625 24.2 24 2 vascular smooth muscle hypertrophy 0.25588116604667 0.501311364021673 0.771187277755828 0.625 24.2 24 2 short ureter 0.25588116604667 0.501311364021673 0.771187277755828 0.625 24.2 24 2 absent tympanic ring 0.25588116604667 0.501311364021673 0.771187277755828 0.625 24.2 24 2 early eyelid opening 0.25588116604667 0.501311364021673 0.771187277755828 0.625 24.2 24 2 abnormal soft palate morphology 0.25588116604667 0.501311364021673 0.771187277755828 0.625 24.2 24 2 decreased circulating renin level 0.25588116604667 0.501311364021673 0.771187277755828 0.625 24.2 24 2 increased left ventricle systolic pressure 0.25588116604667 0.501311364021673 0.771187277755828 0.625 24.2 24 2 thin stria vascularis 0.25588116604667 0.501311364021673 0.771187277755828 0.625 24.2 24 2 increased epididymis weight 0.25588116604667 0.501311364021673 0.771187277755828 0.625 24.2 24 2 ocular hypertension 0.25588116604667 0.501311364021673 0.771187277755828 0.625 24.2 24 2 abnormal ilium morphology 0.25588116604667 0.501311364021673 0.771187277755828 0.625 24.2 24 2 abnormal mast cell differentiation 0.25588116604667 0.501311364021673 0.771187277755828 0.625 24.2 24 2 stomach epithelial hyperplasia 0.25588116604667 0.501311364021673 0.771187277755828 0.625 24.2 24 2 choroidal neovascularization 0.25588116604667 0.501311364021673 0.771187277755828 0.625 24.2 24 2 increased pulmonary ventilation 0.25588116604667 0.501311364021673 0.771187277755828 0.625 24.2 24 2 decreased hippocampus pyramidal cell number 0.25588116604667 0.501311364021673 0.771187277755828 0.625 24.2 24 2 decreased serotonin level 0.25588116604667 0.501311364021673 0.771187277755828 0.625 24.2 24 2 myocardial trabeculae hypoplasia 0.25588116604667 0.501311364021673 0.771187277755828 0.625 24.2 24 2 sinoatrial block 0.25588116604667 0.501311364021673 0.771187277755828 0.625 24.2 24 2 increased heart right ventricle size 0.25588116604667 0.501311364021673 0.771187277755828 0.625 24.2 24 2 impaired mucociliary clearance 0.25588116604667 0.501311364021673 0.771187277755828 0.625 24.2 24 2 abnormal stomach position or orientation 0.25588116604667 0.501311364021673 0.771187277755828 0.625 24.2 24 2 abnormal bronchiole epithelium morphology 0.25588116604667 0.501311364021673 0.771187277755828 0.625 24.2 24 2 increased airway resistance 0.25588116604667 0.501311364021673 0.771187277755828 0.625 24.2 24 2 absent Reichert's membrane 0.25588116604667 0.501311364021673 0.771187277755828 0.625 24.2 24 2 increased testis apoptosis 0.25588116604667 0.501311364021673 0.771187277755828 0.625 24.2 24 2 increased mammary gland apoptosis 0.25588116604667 0.501311364021673 0.771187277755828 0.625 24.2 24 2 decreased basal metabolism 0.25588116604667 0.501311364021673 0.771187277755828 0.625 24.2 24 2 small kidney 0.000604926589962975 0.00564635982188705 0.771187277755828 0.625 24.2 24 2 abnormal cardiovascular system physiology 3.11019627290435e-05 0.000442092184505689 0.770027597638902 0.62406015037594 24.2 24 2 abnormal coat appearance 0.00248809818980359 0.0177085672307194 0.768951952313057 0.623188405797101 24.2 24 2 abnormal pancreatic islet morphology 0.00774092836417159 0.0457376705602775 0.768277137085051 0.622641509433962 24.2 24 2 hyperactivity 7.39211379099389e-12 3.83080896981194e-10 0.768277137085051 0.622641509433962 24.2 24 2 thin ventricular wall 0.000635789649508159 0.00587703191481544 0.76775977874358 0.622222222222222 24.2 24 2 abnormal pancreatic beta cell physiology 0.0249948445741526 0.112228656819864 0.767018697876066 0.621621621621622 24.2 24 2 glomerulosclerosis 0.00594939191156694 0.0367223632258629 0.765868744805787 0.620689655172414 24.2 24 2 abnormal parietal bone morphology 0.0460096904426445 0.175535437079875 0.765868744805787 0.620689655172414 24.2 24 2 focal hair loss 0.0460096904426445 0.175535437079875 0.765868744805787 0.620689655172414 24.2 24 2 decreased bone strength 0.0460096904426445 0.175535437079875 0.765868744805787 0.620689655172414 24.2 24 2 abnormal myocardium layer morphology 0.0014923762494268 0.0117850346680926 0.765330159190593 0.620253164556962 24.2 24 2 decreased heart rate 0.000385013827238397 0.00377055864273824 0.765017779533781 0.62 24.2 24 2 increased circulating chloride level 0.0105670582997572 0.0579615380830124 0.765017779533781 0.62 24.2 24 2 increased bone mineral density 0.000173878212154357 0.00193522171245621 0.764362611580997 0.619469026548673 24.2 24 2 abnormal optic nerve morphology 0.0189609557361816 0.0888236862405869 0.763842637015296 0.619047619047619 24.2 24 2 small ears 0.0871545370465351 0.270948434330732 0.763842637015296 0.619047619047619 24.2 24 2 abnormal salivary gland morphology 0.0871545370465351 0.270948434330732 0.763842637015296 0.619047619047619 24.2 24 2 trunk curl 0.0871545370465351 0.270948434330732 0.763842637015296 0.619047619047619 24.2 24 2 lung hemorrhage 0.0345110202313332 0.143741362647307 0.762114486252818 0.617647058823529 24.2 24 2 overexpanded pulmonary alveoli 0.0345110202313332 0.143741362647307 0.762114486252818 0.617647058823529 24.2 24 2 decreased regulatory T cell number 0.0345110202313332 0.143741362647307 0.762114486252818 0.617647058823529 24.2 24 2 abnormal skin physiology 0.0345110202313332 0.143741362647307 0.762114486252818 0.617647058823529 24.2 24 2 increased exploration in new environment 0.0015603928028577 0.0121485981130158 0.76166644716625 0.617283950617284 24.2 24 2 abnormal kidney morphology 4.60892231304615e-06 8.13098883241298e-05 0.761492351978326 0.617142857142857 24.2 24 2 reduced long term potentiation 0.000243876857232061 0.00260362095435516 0.76017031664503 0.616071428571429 24.2 24 2 abnormal locomotor activation 0.000936813231215913 0.00803559625051581 0.759322858098046 0.615384615384615 24.2 24 2 decreased kidney weight 0.0110176637845219 0.0595145247860981 0.759322858098046 0.615384615384615 24.2 24 2 abnormal brain wave pattern 0.0110176637845219 0.0595145247860981 0.759322858098046 0.615384615384615 24.2 24 2 abnormal kidney cortex morphology 0.0641714962500916 0.229183915178899 0.759322858098046 0.615384615384615 24.2 24 2 abnormal Schwann cell morphology 0.0641714962500916 0.229183915178899 0.759322858098046 0.615384615384615 24.2 24 2 thick skin 0.0641714962500916 0.229183915178899 0.759322858098046 0.615384615384615 24.2 24 2 absent trabeculae carneae 0.174199413392541 0.443749145738808 0.759322858098046 0.615384615384615 24.2 24 2 uterus hypoplasia 0.174199413392541 0.443749145738808 0.759322858098046 0.615384615384615 24.2 24 2 abnormal otolith morphology 0.174199413392541 0.443749145738808 0.759322858098046 0.615384615384615 24.2 24 2 abnormal soleus morphology 0.174199413392541 0.443749145738808 0.759322858098046 0.615384615384615 24.2 24 2 muscle fatigue 0.174199413392541 0.443749145738808 0.759322858098046 0.615384615384615 24.2 24 2 increased cochlear inner hair cell number 0.174199413392541 0.443749145738808 0.759322858098046 0.615384615384615 24.2 24 2 decreased endocochlear potential 0.174199413392541 0.443749145738808 0.759322858098046 0.615384615384615 24.2 24 2 abnormal vertebral arch development 0.174199413392541 0.443749145738808 0.759322858098046 0.615384615384615 24.2 24 2 small pituitary gland 0.174199413392541 0.443749145738808 0.759322858098046 0.615384615384615 24.2 24 2 orthokeratosis 0.174199413392541 0.443749145738808 0.759322858098046 0.615384615384615 24.2 24 2 abnormal hair follicle inner root sheath morphology 0.174199413392541 0.443749145738808 0.759322858098046 0.615384615384615 24.2 24 2 acanthosis 0.026031719445238 0.115445447210304 0.759322858098046 0.615384615384615 24.2 24 2 abnormal circulating hormone level 0.026031719445238 0.115445447210304 0.759322858098046 0.615384615384615 24.2 24 2 hyperglycemia 0.00125925958597734 0.0102199289400282 0.75716569088754 0.613636363636364 24.2 24 2 abnormal gametogenesis 0.0197237820202148 0.0909414416594705 0.75716569088754 0.613636363636364 24.2 24 2 cochlear hair cell degeneration 0.0197237820202148 0.0909414416594705 0.75716569088754 0.613636363636364 24.2 24 2 abnormal limb morphology 0.00283628872943198 0.0198460427973616 0.756791781904386 0.613333333333333 24.2 24 2 abnormal cranial ganglia morphology 0.0477351491350967 0.178577017733858 0.756261072379909 0.612903225806452 24.2 24 2 abnormal nose morphology 0.0477351491350967 0.178577017733858 0.756261072379909 0.612903225806452 24.2 24 2 increased circulating insulin level 1.9455361692237e-05 0.000293304316420846 0.755763532200711 0.6125 24.2 24 2 abnormal long bone hypertrophic chondrocyte zone 0.0149990661934684 0.0774873876557689 0.75544876188326 0.612244897959184 24.2 24 2 abnormal epidermis stratum corneum morphology 0.0149990661934684 0.0774873876557689 0.75544876188326 0.612244897959184 24.2 24 2 abnormal craniofacial development 0.0149990661934684 0.0774873876557689 0.75544876188326 0.612244897959184 24.2 24 2 decreased litter size 1.97089269377492e-08 5.9425400918365e-07 0.755269533232754 0.612099644128114 24.2 24 2 abnormal systemic arterial blood pressure 0.0357765637508453 0.147830900880777 0.754049782694587 0.611111111111111 24.2 24 2 short radius 0.0357765637508453 0.147830900880777 0.754049782694587 0.611111111111111 24.2 24 2 head tilt 0.0357765637508453 0.147830900880777 0.754049782694587 0.611111111111111 24.2 24 2 lowered ear position 0.123674086448675 0.350071857866991 0.754049782694587 0.611111111111111 24.2 24 2 abnormal radius morphology 0.123674086448675 0.350071857866991 0.754049782694587 0.611111111111111 24.2 24 2 abnormal retinal rod cell morphology 0.123674086448675 0.350071857866991 0.754049782694587 0.611111111111111 24.2 24 2 abnormal phrenic nerve morphology 0.123674086448675 0.350071857866991 0.754049782694587 0.611111111111111 24.2 24 2 blepharoptosis 0.123674086448675 0.350071857866991 0.754049782694587 0.611111111111111 24.2 24 2 decreased heart rate variability 0.123674086448675 0.350071857866991 0.754049782694587 0.611111111111111 24.2 24 2 atrioventricular block 0.123674086448675 0.350071857866991 0.754049782694587 0.611111111111111 24.2 24 2 abnormal long bone epiphyseal plate proliferative zone 0.0114408899462516 0.0616667686702078 0.754049782694587 0.611111111111111 24.2 24 2 abnormal osteoblast physiology 0.0114408899462516 0.0616667686702078 0.754049782694587 0.611111111111111 24.2 24 2 delayed wound healing 0.0204235310548795 0.0936470663576274 0.751069348770893 0.608695652173913 24.2 24 2 fragile skeleton 0.0898078328063071 0.270948434330732 0.751069348770893 0.608695652173913 24.2 24 2 abnormal circulating insulin level 0.0898078328063071 0.270948434330732 0.751069348770893 0.608695652173913 24.2 24 2 abnormal postnatal growth 0.0898078328063071 0.270948434330732 0.751069348770893 0.608695652173913 24.2 24 2 abnormal lens development 0.0898078328063071 0.270948434330732 0.751069348770893 0.608695652173913 24.2 24 2 abnormal basicranium morphology 0.0898078328063071 0.270948434330732 0.751069348770893 0.608695652173913 24.2 24 2 abnormal myocardial fiber morphology 0.00105061050982337 0.00876977732612628 0.750516278558249 0.608247422680412 24.2 24 2 abnormal gluconeogenesis 0.0155245117771356 0.0793776424370502 0.750017430915472 0.607843137254902 24.2 24 2 increased kidney weight 0.0155245117771356 0.0793776424370502 0.750017430915472 0.607843137254902 24.2 24 2 hunched posture 0.00305103350215158 0.0211995693759834 0.749711176349969 0.607594936708861 24.2 24 2 short mandible 0.0118373678345372 0.063528484333142 0.749153355534233 0.607142857142857 24.2 24 2 rib bifurcation 0.0661565247827355 0.231308004962795 0.749153355534233 0.607142857142857 24.2 24 2 abnormal retinal inner nuclear layer morphology 0.0661565247827355 0.231308004962795 0.749153355534233 0.607142857142857 24.2 24 2 enhanced coordination 0.0661565247827355 0.231308004962795 0.749153355534233 0.607142857142857 24.2 24 2 hypoxia 0.0661565247827355 0.231308004962795 0.749153355534233 0.607142857142857 24.2 24 2 abnormal tooth development 0.0492230544822538 0.181665204784283 0.747817966308681 0.606060606060606 24.2 24 2 belly spot 0.0492230544822538 0.181665204784283 0.747817966308681 0.606060606060606 24.2 24 2 corneal opacity 0.00532334401940008 0.0330632165998944 0.747291333938042 0.605633802816901 24.2 24 2 decreased liver weight 0.00532334401940008 0.0330632165998944 0.747291333938042 0.605633802816901 24.2 24 2 seizures 0.000506051401712879 0.00477724046209027 0.746833995300381 0.605263157894737 24.2 24 2 hyporesponsive to tactile stimuli 0.0368957261610516 0.152076418932255 0.746833995300381 0.605263157894737 24.2 24 2 abnormal hair follicle morphology 0.00933260384436632 0.0518188662117438 0.744256928373878 0.603174603174603 24.2 24 2 polydactyly 0.00149604747979549 0.0117953030300833 0.742857949185206 0.602040816326531 24.2 24 2 abnormal contextual conditioning behavior 0.0164595680071756 0.0838140745503566 0.740339786645595 0.6 24.2 24 2 decreased respiratory quotient 0.0216470780340353 0.0990747131732526 0.740339786645595 0.6 24.2 24 2 abnormal cellular respiration 0.0677990708159552 0.231821565161084 0.740339786645595 0.6 24.2 24 2 abnormal cochlear outer hair cell morphology 0.0918848478184682 0.277046738119321 0.740339786645595 0.6 24.2 24 2 decreased chondrocyte number 0.176815714960917 0.446945248192419 0.740339786645595 0.6 24.2 24 2 joint inflammation 0.176815714960917 0.446945248192419 0.740339786645595 0.6 24.2 24 2 arthritis 0.176815714960917 0.446945248192419 0.740339786645595 0.6 24.2 24 2 abnormal glial cell morphology 0.176815714960917 0.446945248192419 0.740339786645595 0.6 24.2 24 2 abnormal pericyte morphology 0.176815714960917 0.446945248192419 0.740339786645595 0.6 24.2 24 2 abnormal energy homeostasis 0.176815714960917 0.446945248192419 0.740339786645595 0.6 24.2 24 2 abnormal secondary palate development 0.176815714960917 0.446945248192419 0.740339786645595 0.6 24.2 24 2 liver vascular congestion 0.176815714960917 0.446945248192419 0.740339786645595 0.6 24.2 24 2 abnormal coronary vessel morphology 0.176815714960917 0.446945248192419 0.740339786645595 0.6 24.2 24 2 altered response to myocardial infarction 0.0285729039109981 0.12447477842138 0.740339786645595 0.6 24.2 24 2 cardiomyopathy 0.0285729039109981 0.12447477842138 0.740339786645595 0.6 24.2 24 2 decreased circulating phosphate level 0.0378815542162342 0.155881498946042 0.740339786645595 0.6 24.2 24 2 abnormal female reproductive system morphology 0.0378815542162342 0.155881498946042 0.740339786645595 0.6 24.2 24 2 abnormal dopamine level 0.126186044728191 0.350071857866991 0.740339786645595 0.6 24.2 24 2 abnormal trachea morphology 0.126186044728191 0.350071857866991 0.740339786645595 0.6 24.2 24 2 absent placental labyrinth 0.126186044728191 0.350071857866991 0.740339786645595 0.6 24.2 24 2 abnormal male reproductive system physiology 0.126186044728191 0.350071857866991 0.740339786645595 0.6 24.2 24 2 kidney atrophy 0.126186044728191 0.350071857866991 0.740339786645595 0.6 24.2 24 2 enlarged testis 0.256550499055111 0.501311364021673 0.740339786645595 0.6 24.2 24 2 abnormal prostate gland epithelium morphology 0.256550499055111 0.501311364021673 0.740339786645595 0.6 24.2 24 2 abnormal grooming behavior 0.256550499055111 0.501311364021673 0.740339786645595 0.6 24.2 24 2 absent trophoblast giant cells 0.256550499055111 0.501311364021673 0.740339786645595 0.6 24.2 24 2 abnormal pituitary secretion 0.256550499055111 0.501311364021673 0.740339786645595 0.6 24.2 24 2 abnormal PNS synaptic transmission 0.256550499055111 0.501311364021673 0.740339786645595 0.6 24.2 24 2 increased natural killer cell mediated cytotoxicity 0.256550499055111 0.501311364021673 0.740339786645595 0.6 24.2 24 2 aneurysm 0.256550499055111 0.501311364021673 0.740339786645595 0.6 24.2 24 2 abnormal hypaxial muscle morphology 0.256550499055111 0.501311364021673 0.740339786645595 0.6 24.2 24 2 lymphedema 0.256550499055111 0.501311364021673 0.740339786645595 0.6 24.2 24 2 absent CD4-positive, alpha beta T cells 0.256550499055111 0.501311364021673 0.740339786645595 0.6 24.2 24 2 increased atrioventricular cushion size 0.256550499055111 0.501311364021673 0.740339786645595 0.6 24.2 24 2 absent pharyngeal arches 0.256550499055111 0.501311364021673 0.740339786645595 0.6 24.2 24 2 abnormal ear physiology 0.256550499055111 0.501311364021673 0.740339786645595 0.6 24.2 24 2 increased heart rate variability 0.256550499055111 0.501311364021673 0.740339786645595 0.6 24.2 24 2 abnormal cochlear inner hair cell physiology 0.256550499055111 0.501311364021673 0.740339786645595 0.6 24.2 24 2 ascites 0.256550499055111 0.501311364021673 0.740339786645595 0.6 24.2 24 2 abnormal gonadal fat pad morphology 0.256550499055111 0.501311364021673 0.740339786645595 0.6 24.2 24 2 decreased thyroxine level 0.256550499055111 0.501311364021673 0.740339786645595 0.6 24.2 24 2 absent axillary lymph nodes 0.256550499055111 0.501311364021673 0.740339786645595 0.6 24.2 24 2 increased serotonin level 0.256550499055111 0.501311364021673 0.740339786645595 0.6 24.2 24 2 thick aortic valve 0.256550499055111 0.501311364021673 0.740339786645595 0.6 24.2 24 2 fusion of atlas and odontoid process 0.256550499055111 0.501311364021673 0.740339786645595 0.6 24.2 24 2 decreased trabecular bone connectivity density 0.256550499055111 0.501311364021673 0.740339786645595 0.6 24.2 24 2 increased compact bone area 0.256550499055111 0.501311364021673 0.740339786645595 0.6 24.2 24 2 abnormal circadian temperature homeostasis 0.256550499055111 0.501311364021673 0.740339786645595 0.6 24.2 24 2 decreased circulating lactate level 0.256550499055111 0.501311364021673 0.740339786645595 0.6 24.2 24 2 abnormal excitatory postsynaptic potential 0.00445986411770091 0.0285925566824253 0.737330275317767 0.597560975609756 24.2 24 2 cochlear outer hair cell degeneration 0.00754900988766364 0.0447099097513412 0.736912287633347 0.597222222222222 24.2 24 2 improved glucose tolerance 1.80200262316867e-05 0.00027249127812353 0.736562542836178 0.596938775510204 24.2 24 2 abnormal circulating amino acid level 0.0168725827560167 0.0843723760424559 0.736010314209071 0.596491228070175 24.2 24 2 absent corpus luteum 0.0221774778614704 0.10131584238826 0.735594018782482 0.596153846153846 24.2 24 2 abnormal hair growth 0.0221774778614704 0.10131584238826 0.735594018782482 0.596153846153846 24.2 24 2 deafness 0.0020993290814834 0.0151990640573926 0.73535433353687 0.595959595959596 24.2 24 2 pulmonary hypoplasia 0.0292519149211231 0.126766791578909 0.735089149860874 0.595744680851064 24.2 24 2 abnormal cartilage morphology 0.0387460200263531 0.155917380808581 0.734464074053169 0.595238095238095 24.2 24 2 small seminiferous tubules 0.00773135774273836 0.0457354396791003 0.733670058837977 0.594594594594595 24.2 24 2 increased brown adipose tissue amount 0.0515897518766616 0.189137078545609 0.733670058837977 0.594594594594595 24.2 24 2 impaired skeletal muscle contractility 0.0515897518766616 0.189137078545609 0.733670058837977 0.594594594594595 24.2 24 2 hyperkeratosis 0.0100810082010911 0.0559119462658064 0.733186745228729 0.594202898550725 24.2 24 2 polydipsia 0.0691469144093269 0.236105627444338 0.732627913868036 0.59375 24.2 24 2 abnormal lumbar vertebrae morphology 0.0691469144093269 0.236105627444338 0.732627913868036 0.59375 24.2 24 2 abnormal thoracic vertebrae morphology 0.0172515540901863 0.0843723760424559 0.731974365327565 0.593220338983051 24.2 24 2 organ of Corti degeneration 0.0298569801011813 0.129051673330475 0.730267136487151 0.591836734693878 24.2 24 2 increased fluid intake 0.0298569801011813 0.129051673330475 0.730267136487151 0.591836734693878 24.2 24 2 abnormal suckling behavior 0.00477723216986166 0.0299458323332507 0.729122517150964 0.590909090909091 24.2 24 2 hypertension 0.0395000517866884 0.155917380808581 0.729122517150964 0.590909090909091 24.2 24 2 abnormal basisphenoid bone morphology 0.127916403576834 0.350071857866991 0.729122517150964 0.590909090909091 24.2 24 2 abnormal enterocyte morphology 0.127916403576834 0.350071857866991 0.729122517150964 0.590909090909091 24.2 24 2 abnormal tail movements 0.127916403576834 0.350071857866991 0.729122517150964 0.590909090909091 24.2 24 2 decreased airway responsiveness 0.127916403576834 0.350071857866991 0.729122517150964 0.590909090909091 24.2 24 2 aphakia 0.127916403576834 0.350071857866991 0.729122517150964 0.590909090909091 24.2 24 2 decreased cardiac output 0.127916403576834 0.350071857866991 0.729122517150964 0.590909090909091 24.2 24 2 abnormal retinal layer morphology 0.127916403576834 0.350071857866991 0.729122517150964 0.590909090909091 24.2 24 2 abnormal limb posture 0.127916403576834 0.350071857866991 0.729122517150964 0.590909090909091 24.2 24 2 abnormal basement membrane morphology 0.127916403576834 0.350071857866991 0.729122517150964 0.590909090909091 24.2 24 2 decreased circulating estradiol level 0.127916403576834 0.350071857866991 0.729122517150964 0.590909090909091 24.2 24 2 pulmonary vascular congestion 0.127916403576834 0.350071857866991 0.729122517150964 0.590909090909091 24.2 24 2 impaired humoral immune response 0.127916403576834 0.350071857866991 0.729122517150964 0.590909090909091 24.2 24 2 abnormal male meiosis 0.0175981896337088 0.0844950244942328 0.728203068831732 0.590163934426229 24.2 24 2 abnormal excitatory postsynaptic currents 0.00806365165964708 0.046777049633943 0.727684405677294 0.58974358974359 24.2 24 2 abnormal heart ventricle morphology 0.00806365165964708 0.046777049633943 0.727684405677294 0.58974358974359 24.2 24 2 abnormal retinal photoreceptor morphology 0.0702402462692835 0.239674365699373 0.725823320240779 0.588235294117647 24.2 24 2 abnormal vagus nerve morphology 0.178123172513632 0.446945248192419 0.725823320240779 0.588235294117647 24.2 24 2 increased incidence of corneal inflammation 0.178123172513632 0.446945248192419 0.725823320240779 0.588235294117647 24.2 24 2 abnormal heart rate 0.178123172513632 0.446945248192419 0.725823320240779 0.588235294117647 24.2 24 2 abnormal touch/ nociception 0.178123172513632 0.446945248192419 0.725823320240779 0.588235294117647 24.2 24 2 nephrocalcinosis 0.178123172513632 0.446945248192419 0.725823320240779 0.588235294117647 24.2 24 2 abnormal testis development 0.178123172513632 0.446945248192419 0.725823320240779 0.588235294117647 24.2 24 2 abnormal tarsal bone morphology 0.178123172513632 0.446945248192419 0.725823320240779 0.588235294117647 24.2 24 2 abnormal cell cytoskeleton morphology 0.178123172513632 0.446945248192419 0.725823320240779 0.588235294117647 24.2 24 2 abnormal social investigation 0.00821419247928664 0.0470260156322796 0.724916041090478 0.5875 24.2 24 2 increased double-positive T cell number 0.0946978734311979 0.285010236128379 0.723320481205466 0.586206896551724 24.2 24 2 impaired fertilization 0.0139343186183626 0.0738192894313789 0.722712648868319 0.585714285714286 24.2 24 2 dehydration 0.0139343186183626 0.0738192894313789 0.722712648868319 0.585714285714286 24.2 24 2 abnormal response/metabolism to endogenous compounds 0.00835474677267758 0.0476115294319255 0.722282718678629 0.585365853658537 24.2 24 2 short humerus 0.0532872363415887 0.195216495434023 0.722282718678629 0.585365853658537 24.2 24 2 abnormal kidney development 0.0238293048363383 0.10748362669608 0.719774792572106 0.583333333333333 24.2 24 2 abnormal intestinal epithelium morphology 0.0407156666211469 0.157442285486612 0.719774792572106 0.583333333333333 24.2 24 2 abnormal hair shaft morphology 0.0407156666211469 0.157442285486612 0.719774792572106 0.583333333333333 24.2 24 2 abnormal limb bone morphology 0.0711130173748257 0.242320042082026 0.719774792572106 0.583333333333333 24.2 24 2 abnormal digestive system morphology 0.129037032295784 0.350071857866991 0.719774792572106 0.583333333333333 24.2 24 2 abnormal body weight 0.129037032295784 0.350071857866991 0.719774792572106 0.583333333333333 24.2 24 2 increased stereotypic behavior 0.129037032295784 0.350071857866991 0.719774792572106 0.583333333333333 24.2 24 2 apnea 0.129037032295784 0.350071857866991 0.719774792572106 0.583333333333333 24.2 24 2 abnormal cardiac muscle contractility 0.129037032295784 0.350071857866991 0.719774792572106 0.583333333333333 24.2 24 2 abnormal impulse conducting system conduction 0.129037032295784 0.350071857866991 0.719774792572106 0.583333333333333 24.2 24 2 prolonged QT interval 0.129037032295784 0.350071857866991 0.719774792572106 0.583333333333333 24.2 24 2 abnormal mineral level 0.255225895432369 0.501311364021673 0.719774792572106 0.583333333333333 24.2 24 2 amyloidosis 0.255225895432369 0.501311364021673 0.719774792572106 0.583333333333333 24.2 24 2 abnormal enteric nervous system morphology 0.255225895432369 0.501311364021673 0.719774792572106 0.583333333333333 24.2 24 2 absent optic nerve 0.255225895432369 0.501311364021673 0.719774792572106 0.583333333333333 24.2 24 2 abnormal pilomotor reflex 0.255225895432369 0.501311364021673 0.719774792572106 0.583333333333333 24.2 24 2 impaired embryo implantation 0.255225895432369 0.501311364021673 0.719774792572106 0.583333333333333 24.2 24 2 abnormal tracheal ciliated epithelium morphology 0.255225895432369 0.501311364021673 0.719774792572106 0.583333333333333 24.2 24 2 abnormal AMPA-mediated synaptic currents 0.255225895432369 0.501311364021673 0.719774792572106 0.583333333333333 24.2 24 2 decreased synaptic depression 0.255225895432369 0.501311364021673 0.719774792572106 0.583333333333333 24.2 24 2 small thyroid gland 0.255225895432369 0.501311364021673 0.719774792572106 0.583333333333333 24.2 24 2 dilated bile duct 0.255225895432369 0.501311364021673 0.719774792572106 0.583333333333333 24.2 24 2 increased fear-related response 0.255225895432369 0.501311364021673 0.719774792572106 0.583333333333333 24.2 24 2 impaired sperm capacitation 0.255225895432369 0.501311364021673 0.719774792572106 0.583333333333333 24.2 24 2 increased hepatocyte proliferation 0.255225895432369 0.501311364021673 0.719774792572106 0.583333333333333 24.2 24 2 vestibular saccular macula degeneration 0.255225895432369 0.501311364021673 0.719774792572106 0.583333333333333 24.2 24 2 bowed ulna 0.255225895432369 0.501311364021673 0.719774792572106 0.583333333333333 24.2 24 2 decreased cochlear nerve compound action potential 0.255225895432369 0.501311364021673 0.719774792572106 0.583333333333333 24.2 24 2 abnormal cochlear outer hair cell physiology 0.255225895432369 0.501311364021673 0.719774792572106 0.583333333333333 24.2 24 2 abnormal thymus corticomedullary boundary morphology 0.255225895432369 0.501311364021673 0.719774792572106 0.583333333333333 24.2 24 2 hydrometra 0.255225895432369 0.501311364021673 0.719774792572106 0.583333333333333 24.2 24 2 reduced cerebellar foliation 0.255225895432369 0.501311364021673 0.719774792572106 0.583333333333333 24.2 24 2 impaired behavioral response to cocaine 0.255225895432369 0.501311364021673 0.719774792572106 0.583333333333333 24.2 24 2 decreased oligodendrocyte number 0.255225895432369 0.501311364021673 0.719774792572106 0.583333333333333 24.2 24 2 abnormal aorta elastic tissue morphology 0.255225895432369 0.501311364021673 0.719774792572106 0.583333333333333 24.2 24 2 increased type II pneumocyte number 0.255225895432369 0.501311364021673 0.719774792572106 0.583333333333333 24.2 24 2 abnormal respiratory motile cilium morphology 0.255225895432369 0.501311364021673 0.719774792572106 0.583333333333333 24.2 24 2 decreased exploration in new environment 0.00848563744696099 0.0483021124698295 0.719774792572106 0.583333333333333 24.2 24 2 increased anxiety-related response 0.000921490127503393 0.00798786493637552 0.719035044583851 0.58273381294964 24.2 24 2 abnormal skeleton morphology 0.00245302270660356 0.0174839369131128 0.718880662394998 0.582608695652174 24.2 24 2 increased thermal nociceptive threshold 0.00663982384994158 0.0400660051019043 0.718644847842793 0.582417582417582 24.2 24 2 abnormal podocyte morphology 0.0955798854509904 0.287143677607897 0.716457858044124 0.580645161290323 24.2 24 2 preaxial polydactyly 0.0955798854509904 0.287143677607897 0.716457858044124 0.580645161290323 24.2 24 2 abnormal facial morphology 0.031642322228846 0.136412957615692 0.714362952026451 0.578947368421053 24.2 24 2 abnormal reproductive system physiology 0.0717940372356254 0.244138985131399 0.714362952026451 0.578947368421053 24.2 24 2 impaired branching involved in ureteric bud morphogenesis 0.0717940372356254 0.244138985131399 0.714362952026451 0.578947368421053 24.2 24 2 decreased threshold for auditory brainstem response 0.0717940372356254 0.244138985131399 0.714362952026451 0.578947368421053 24.2 24 2 irregular coat pigmentation 0.17850858455444 0.446945248192419 0.714362952026451 0.578947368421053 24.2 24 2 abnormal nail morphology 0.17850858455444 0.446945248192419 0.714362952026451 0.578947368421053 24.2 24 2 flaky skin 0.17850858455444 0.446945248192419 0.714362952026451 0.578947368421053 24.2 24 2 short vibrissae 0.17850858455444 0.446945248192419 0.714362952026451 0.578947368421053 24.2 24 2 abnormal optic vesicle formation 0.17850858455444 0.446945248192419 0.714362952026451 0.578947368421053 24.2 24 2 increased circulating VLDL cholesterol level 0.17850858455444 0.446945248192419 0.714362952026451 0.578947368421053 24.2 24 2 eyelids fail to open 0.17850858455444 0.446945248192419 0.714362952026451 0.578947368421053 24.2 24 2 right-sided stomach 0.17850858455444 0.446945248192419 0.714362952026451 0.578947368421053 24.2 24 2 abnormal vertebrae morphology 0.00418859096778224 0.0274910818795734 0.713171354108142 0.577981651376147 24.2 24 2 abnormal metabolism 0.0544529909850009 0.199193845698809 0.71291979454761 0.577777777777778 24.2 24 2 abnormal xiphoid process morphology 0.129675781775345 0.351113395382598 0.711865179466918 0.576923076923077 24.2 24 2 small seminal vesicle 0.129675781775345 0.351113395382598 0.711865179466918 0.576923076923077 24.2 24 2 abnormal skin pigmentation 0.0723078638604679 0.245550595703637 0.709492295535361 0.575 24.2 24 2 increased total body fat amount 0.00207911471877611 0.0151990640573926 0.709031885220283 0.574626865671642 24.2 24 2 abnormal tibia morphology 0.0548708552431566 0.200427683432235 0.708835965937271 0.574468085106383 24.2 24 2 increased systemic arterial blood pressure 0.0548708552431566 0.200427683432235 0.708835965937271 0.574468085106383 24.2 24 2 abnormal mandible morphology 0.0419312217611151 0.160714813760822 0.708349795864612 0.574074074074074 24.2 24 2 abnormal urine homeostasis 0.00908632284298627 0.0505642686172894 0.706921671276176 0.572916666666667 24.2 24 2 abnormal trabecular bone morphology 0.00439790394725114 0.0284150287500966 0.705085511091043 0.571428571428571 24.2 24 2 enhanced long term potentiation 0.042202014474214 0.161628192462829 0.705085511091043 0.571428571428571 24.2 24 2 abnormal circulating cholesterol level 0.129929600180776 0.351113395382598 0.705085511091043 0.571428571428571 24.2 24 2 abnormal ovulation 0.129929600180776 0.351113395382598 0.705085511091043 0.571428571428571 24.2 24 2 corneal vascularization 0.129929600180776 0.351113395382598 0.705085511091043 0.571428571428571 24.2 24 2 abnormal vasoconstriction 0.252781154919249 0.501311364021673 0.705085511091043 0.571428571428571 24.2 24 2 increased aggression towards males 0.252781154919249 0.501311364021673 0.705085511091043 0.571428571428571 24.2 24 2 abnormal kidney medulla morphology 0.252781154919249 0.501311364021673 0.705085511091043 0.571428571428571 24.2 24 2 abnormal voluntary movement 0.252781154919249 0.501311364021673 0.705085511091043 0.571428571428571 24.2 24 2 abnormal uterus development 0.252781154919249 0.501311364021673 0.705085511091043 0.571428571428571 24.2 24 2 abnormal imprinting 0.252781154919249 0.501311364021673 0.705085511091043 0.571428571428571 24.2 24 2 abnormal decidualization 0.252781154919249 0.501311364021673 0.705085511091043 0.571428571428571 24.2 24 2 abnormal pancreas development 0.252781154919249 0.501311364021673 0.705085511091043 0.571428571428571 24.2 24 2 premature hair loss 0.252781154919249 0.501311364021673 0.705085511091043 0.571428571428571 24.2 24 2 decreased tongue size 0.252781154919249 0.501311364021673 0.705085511091043 0.571428571428571 24.2 24 2 abnormal respiratory motile cilium physiology 0.252781154919249 0.501311364021673 0.705085511091043 0.571428571428571 24.2 24 2 abnormal nervous system electrophysiology 0.0150686967846845 0.0777663552944037 0.705085511091042 0.571428571428571 24.2 24 2 abnormal muscle morphology 0.0726755247619034 0.246630788329106 0.705085511091042 0.571428571428571 24.2 24 2 abnormal associative learning 0.178228054970399 0.446945248192419 0.705085511091042 0.571428571428571 24.2 24 2 dry skin 0.178228054970399 0.446945248192419 0.705085511091042 0.571428571428571 24.2 24 2 abnormal bile salt homeostasis 0.178228054970399 0.446945248192419 0.705085511091042 0.571428571428571 24.2 24 2 abnormal digit morphology 0.0251920680689984 0.112910395174114 0.702637297510865 0.569444444444444 24.2 24 2 abnormal heart left ventricle morphology 0.0251920680689984 0.112910395174114 0.702637297510865 0.569444444444444 24.2 24 2 increased liver weight 0.0152572475556386 0.0783331337350898 0.701079343414389 0.568181818181818 24.2 24 2 abnormal circadian rhythm 0.0729151022476634 0.24693848446707 0.701079343414389 0.568181818181818 24.2 24 2 abnormal photoreceptor outer segment morphology 0.0729151022476634 0.24693848446707 0.701079343414389 0.568181818181818 24.2 24 2 embryonic lethality, incomplete penetrance 0.0729151022476634 0.24693848446707 0.701079343414389 0.568181818181818 24.2 24 2 kidney cysts 0.0253180072928975 0.113372714925441 0.700321419799887 0.567567567567568 24.2 24 2 abnormal breathing pattern 0.0967373033411656 0.289947524439643 0.700321419799887 0.567567567567568 24.2 24 2 increased insulin secretion 0.0967373033411656 0.289947524439643 0.700321419799887 0.567567567567568 24.2 24 2 abnormal hair cycle 0.129873230697284 0.351113395382598 0.699209798498617 0.566666666666667 24.2 24 2 delayed eyelid opening 0.129873230697284 0.351113395382598 0.699209798498617 0.566666666666667 24.2 24 2 small lens 0.0967463096622729 0.289947524439643 0.696045953256542 0.564102564102564 24.2 24 2 cleft secondary palate 0.015448979881368 0.079235747329697 0.69570937397547 0.563829787234043 24.2 24 2 oligodactyly 0.0730703834714548 0.24712791146872 0.694068549980245 0.5625 24.2 24 2 absent mandible 0.24967901596113 0.501311364021673 0.694068549980245 0.5625 24.2 24 2 white spotting 0.24967901596113 0.501311364021673 0.694068549980245 0.5625 24.2 24 2 paternal imprinting 0.24967901596113 0.501311364021673 0.694068549980245 0.5625 24.2 24 2 decreased cochlear coiling 0.24967901596113 0.501311364021673 0.694068549980245 0.5625 24.2 24 2 abnormal pulmonary elastic fiber morphology 0.24967901596113 0.501311364021673 0.694068549980245 0.5625 24.2 24 2 large intestinal inflammation 0.24967901596113 0.501311364021673 0.694068549980245 0.5625 24.2 24 2 bowed tibia 0.24967901596113 0.501311364021673 0.694068549980245 0.5625 24.2 24 2 decreased circulating growth hormone level 0.24967901596113 0.501311364021673 0.694068549980245 0.5625 24.2 24 2 decreased circulating prolactin level 0.24967901596113 0.501311364021673 0.694068549980245 0.5625 24.2 24 2 abnormal intestinal lipid absorption 0.24967901596113 0.501311364021673 0.694068549980245 0.5625 24.2 24 2 abnormal fertilization 0.24967901596113 0.501311364021673 0.694068549980245 0.5625 24.2 24 2 decreased circulating triiodothyronine level 0.24967901596113 0.501311364021673 0.694068549980245 0.5625 24.2 24 2 dilated respiratory conducting tubes 0.24967901596113 0.501311364021673 0.694068549980245 0.5625 24.2 24 2 increased body weight 0.000349830511142954 0.00350182453307082 0.694068549980245 0.5625 24.2 24 2 abnormal hindlimb morphology 0.07301139892238 0.247096401114858 0.690983800869222 0.56 24.2 24 2 decreased placenta weight 0.176321630721459 0.446945248192419 0.690983800869222 0.56 24.2 24 2 abnormal vertebrae development 0.176321630721459 0.446945248192419 0.690983800869222 0.56 24.2 24 2 abnormal energy expenditure 0.176321630721459 0.446945248192419 0.690983800869222 0.56 24.2 24 2 hydronephrosis 0.0256188349373294 0.114205827789618 0.690396229609979 0.55952380952381 24.2 24 2 thin skin 0.129051615543329 0.350071857866991 0.68953215422874 0.558823529411765 24.2 24 2 polyuria 0.0330376833207378 0.141285703767074 0.689060840384428 0.558441558441558 24.2 24 2 impaired righting response 0.0199420636049245 0.0918627466986107 0.688386117407307 0.557894736842105 24.2 24 2 abnormal maternal nurturing 0.0556206281131595 0.202423280806853 0.687747342785525 0.557377049180328 24.2 24 2 abnormal action potential 0.0427400239582353 0.163562783994016 0.687458373313766 0.557142857142857 24.2 24 2 short femur 0.0256115212803497 0.114205827789618 0.687057756546101 0.556818181818182 24.2 24 2 abnormal epidermis stratum granulosum morphology 0.128369762912696 0.350071857866991 0.685499802449625 0.555555555555556 24.2 24 2 renal hypoplasia 0.128369762912696 0.350071857866991 0.685499802449625 0.555555555555556 24.2 24 2 rectal prolapse 0.174910705481442 0.444877689044057 0.685499802449625 0.555555555555556 24.2 24 2 cryptorchism 0.174910705481442 0.444877689044057 0.685499802449625 0.555555555555556 24.2 24 2 abnormal palate morphology 0.174910705481442 0.444877689044057 0.685499802449625 0.555555555555556 24.2 24 2 abnormal heart shape 0.24618453009483 0.501311364021673 0.685499802449625 0.555555555555556 24.2 24 2 delayed kidney development 0.24618453009483 0.501311364021673 0.685499802449625 0.555555555555556 24.2 24 2 eye inflammation 0.24618453009483 0.501311364021673 0.685499802449625 0.555555555555556 24.2 24 2 abnormal body wall morphology 0.24618453009483 0.501311364021673 0.685499802449625 0.555555555555556 24.2 24 2 absent ureter 0.24618453009483 0.501311364021673 0.685499802449625 0.555555555555556 24.2 24 2 jerky movement 0.24618453009483 0.501311364021673 0.685499802449625 0.555555555555556 24.2 24 2 abnormal glycogen homeostasis 0.24618453009483 0.501311364021673 0.685499802449625 0.555555555555556 24.2 24 2 abnormal sperm axoneme morphology 0.24618453009483 0.501311364021673 0.685499802449625 0.555555555555556 24.2 24 2 decreased fluid intake 0.24618453009483 0.501311364021673 0.685499802449625 0.555555555555556 24.2 24 2 heart hyperplasia 0.373014442524051 0.634125063554901 0.685499802449625 0.555555555555556 24.2 24 2 absent parathyroid glands 0.373014442524051 0.634125063554901 0.685499802449625 0.555555555555556 24.2 24 2 dilated uterus 0.373014442524051 0.634125063554901 0.685499802449625 0.555555555555556 24.2 24 2 psoriasis 0.373014442524051 0.634125063554901 0.685499802449625 0.555555555555556 24.2 24 2 multifocal hepatic necrosis 0.373014442524051 0.634125063554901 0.685499802449625 0.555555555555556 24.2 24 2 abnormal ion homeostasis 0.373014442524051 0.634125063554901 0.685499802449625 0.555555555555556 24.2 24 2 abnormal taste sensitivity 0.373014442524051 0.634125063554901 0.685499802449625 0.555555555555556 24.2 24 2 abnormal vomeronasal organ morphology 0.373014442524051 0.634125063554901 0.685499802449625 0.555555555555556 24.2 24 2 abnormal thymus lobule morphology 0.373014442524051 0.634125063554901 0.685499802449625 0.555555555555556 24.2 24 2 abnormal gut-associated lymphoid tissue morphology 0.373014442524051 0.634125063554901 0.685499802449625 0.555555555555556 24.2 24 2 abnormal NMDA-mediated synaptic currents 0.373014442524051 0.634125063554901 0.685499802449625 0.555555555555556 24.2 24 2 genetic imprinting 0.373014442524051 0.634125063554901 0.685499802449625 0.555555555555556 24.2 24 2 absent posterior semicircular canal 0.373014442524051 0.634125063554901 0.685499802449625 0.555555555555556 24.2 24 2 abnormal lens capsule morphology 0.373014442524051 0.634125063554901 0.685499802449625 0.555555555555556 24.2 24 2 abnormal abdominal wall morphology 0.373014442524051 0.634125063554901 0.685499802449625 0.555555555555556 24.2 24 2 biliary cyst 0.373014442524051 0.634125063554901 0.685499802449625 0.555555555555556 24.2 24 2 premature neuronal precursor differentiation 0.373014442524051 0.634125063554901 0.685499802449625 0.555555555555556 24.2 24 2 decreased susceptibility to induced choroidal neovascularization 0.373014442524051 0.634125063554901 0.685499802449625 0.555555555555556 24.2 24 2 abnormal ovary physiology 0.373014442524051 0.634125063554901 0.685499802449625 0.555555555555556 24.2 24 2 impaired febrile response 0.373014442524051 0.634125063554901 0.685499802449625 0.555555555555556 24.2 24 2 decreased muscle weight 0.373014442524051 0.634125063554901 0.685499802449625 0.555555555555556 24.2 24 2 abnormal stria vascularis vasculature morphology 0.373014442524051 0.634125063554901 0.685499802449625 0.555555555555556 24.2 24 2 abnormal CNS synapse formation 0.373014442524051 0.634125063554901 0.685499802449625 0.555555555555556 24.2 24 2 enhanced conditioned place preference behavior 0.373014442524051 0.634125063554901 0.685499802449625 0.555555555555556 24.2 24 2 abnormal retinal development 0.373014442524051 0.634125063554901 0.685499802449625 0.555555555555556 24.2 24 2 multiflagellated sperm 0.373014442524051 0.634125063554901 0.685499802449625 0.555555555555556 24.2 24 2 abnormal hippocampus granule cell morphology 0.373014442524051 0.634125063554901 0.685499802449625 0.555555555555556 24.2 24 2 abnormal incisor color 0.373014442524051 0.634125063554901 0.685499802449625 0.555555555555556 24.2 24 2 retropulsion 0.373014442524051 0.634125063554901 0.685499802449625 0.555555555555556 24.2 24 2 abnormal ventricle myocardium morphology 0.373014442524051 0.634125063554901 0.685499802449625 0.555555555555556 24.2 24 2 fusion of atlas and occipital bones 0.373014442524051 0.634125063554901 0.685499802449625 0.555555555555556 24.2 24 2 abnormal pulmonary alveolar system morphology 0.373014442524051 0.634125063554901 0.685499802449625 0.555555555555556 24.2 24 2 reduced AMPA-mediated synaptic currents 0.373014442524051 0.634125063554901 0.685499802449625 0.555555555555556 24.2 24 2 decreased pancreatic beta cell proliferation 0.373014442524051 0.634125063554901 0.685499802449625 0.555555555555556 24.2 24 2 decreased bone mineral density of femur 0.373014442524051 0.634125063554901 0.685499802449625 0.555555555555556 24.2 24 2 increased bone mineralization 0.373014442524051 0.634125063554901 0.685499802449625 0.555555555555556 24.2 24 2 enhanced leukocyte tethering or rolling 0.373014442524051 0.634125063554901 0.685499802449625 0.555555555555556 24.2 24 2 adipose tissue inflammation 0.373014442524051 0.634125063554901 0.685499802449625 0.555555555555556 24.2 24 2 abnormal cartilage development 0.0959927413259907 0.288209950571396 0.685499802449625 0.555555555555556 24.2 24 2 abnormal eye electrophysiology 0.0121467960324528 0.0651188688162204 0.683233687400204 0.553719008264463 24.2 24 2 abnormal neuron differentiation 0.0155135957558105 0.0793776424370502 0.683051588869447 0.553571428571429 24.2 24 2 abnormal compact bone morphology 0.127549573236245 0.350071857866991 0.681891908752521 0.552631578947368 24.2 24 2 cochlear ganglion degeneration 0.0720914645271671 0.244982948102907 0.680772217605145 0.551724137931034 24.2 24 2 abnormal circulating glucose level 0.173291725411026 0.443749145738808 0.680772217605145 0.551724137931034 24.2 24 2 decreased retinal photoreceptor cell number 0.173291725411026 0.443749145738808 0.680772217605145 0.551724137931034 24.2 24 2 aphagia 0.173291725411026 0.443749145738808 0.680772217605145 0.551724137931034 24.2 24 2 stomach inflammation 0.173291725411026 0.443749145738808 0.680772217605145 0.551724137931034 24.2 24 2 absent long term depression 0.173291725411026 0.443749145738808 0.680772217605145 0.551724137931034 24.2 24 2 short sternum 0.173291725411026 0.443749145738808 0.680772217605145 0.551724137931034 24.2 24 2 increased retinal apoptosis 0.173291725411026 0.443749145738808 0.680772217605145 0.551724137931034 24.2 24 2 decreased urine osmolality 0.0950096853005248 0.285775806753392 0.679903885694934 0.551020408163265 24.2 24 2 impaired ovarian folliculogenesis 0.126615521197813 0.350071857866991 0.678644804425128 0.55 24.2 24 2 abnormal basioccipital bone morphology 0.242458355453187 0.501311364021673 0.678644804425128 0.55 24.2 24 2 waved hair 0.242458355453187 0.501311364021673 0.678644804425128 0.55 24.2 24 2 increased urine glucose level 0.242458355453187 0.501311364021673 0.678644804425128 0.55 24.2 24 2 decreased paired-pulse facilitation 0.242458355453187 0.501311364021673 0.678644804425128 0.55 24.2 24 2 abnormal hyoid bone morphology 0.242458355453187 0.501311364021673 0.678644804425128 0.55 24.2 24 2 abnormal postnatal subventricular zone morphology 0.242458355453187 0.501311364021673 0.678644804425128 0.55 24.2 24 2 decreased muscle cell glucose uptake 0.242458355453187 0.501311364021673 0.678644804425128 0.55 24.2 24 2 abnormal cued conditioning behavior 0.0944124493115646 0.284323205402563 0.677435098891394 0.549019607843137 24.2 24 2 cochlear inner hair cell degeneration 0.0944124493115646 0.284323205402563 0.677435098891394 0.549019607843137 24.2 24 2 abnormal vibrissa morphology 0.125587731024336 0.350071857866991 0.675706948128916 0.547619047619048 24.2 24 2 impaired swimming 0.070408241176243 0.240082933414537 0.673036169677813 0.545454545454545 24.2 24 2 absent vibrissae 0.169619568337603 0.436211440114396 0.673036169677813 0.545454545454545 24.2 24 2 abnormal channel response 0.238602036642677 0.501311364021673 0.673036169677813 0.545454545454545 24.2 24 2 abnormal retinal outer plexiform layer morphology 0.238602036642677 0.501311364021673 0.673036169677813 0.545454545454545 24.2 24 2 abnormal circulating lipid level 0.238602036642677 0.501311364021673 0.673036169677813 0.545454545454545 24.2 24 2 cleft upper lip 0.238602036642677 0.501311364021673 0.673036169677813 0.545454545454545 24.2 24 2 focal hepatic necrosis 0.360816532304034 0.634125063554901 0.673036169677813 0.545454545454545 24.2 24 2 abnormal hypothalamus secretion 0.360816532304034 0.634125063554901 0.673036169677813 0.545454545454545 24.2 24 2 secondary sex reversal 0.360816532304034 0.634125063554901 0.673036169677813 0.545454545454545 24.2 24 2 dilated renal glomerular capsule 0.360816532304034 0.634125063554901 0.673036169677813 0.545454545454545 24.2 24 2 abnormal pituitary gland development 0.360816532304034 0.634125063554901 0.673036169677813 0.545454545454545 24.2 24 2 enhanced behavioral response to addictive substance 0.360816532304034 0.634125063554901 0.673036169677813 0.545454545454545 24.2 24 2 abnormal aorta smooth muscle morphology 0.360816532304034 0.634125063554901 0.673036169677813 0.545454545454545 24.2 24 2 abnormal extraembryonic ectoderm morphology 0.360816532304034 0.634125063554901 0.673036169677813 0.545454545454545 24.2 24 2 abnormal dendritic cell chemotaxis 0.360816532304034 0.634125063554901 0.673036169677813 0.545454545454545 24.2 24 2 abnormal pulmonary alveolar sac morphology 0.360816532304034 0.634125063554901 0.673036169677813 0.545454545454545 24.2 24 2 decreased food intake 0.0533868221119177 0.195437409865188 0.671616262146847 0.544303797468354 24.2 24 2 abnormal forelimb morphology 0.123314802290946 0.350071857866991 0.670597632831155 0.543478260869565 24.2 24 2 abnormal cardiovascular system morphology 0.12209517164834 0.350071857866991 0.668362307388384 0.541666666666667 24.2 24 2 curly vibrissae 0.234681788549022 0.501311364021673 0.668362307388384 0.541666666666667 24.2 24 2 abnormal startle reflex 0.234681788549022 0.501311364021673 0.668362307388384 0.541666666666667 24.2 24 2 decreased ovulation rate 0.234681788549022 0.501311364021673 0.668362307388384 0.541666666666667 24.2 24 2 abnormal retinal ganglion layer morphology 0.234681788549022 0.501311364021673 0.668362307388384 0.541666666666667 24.2 24 2 hypopigmentation 0.234681788549022 0.501311364021673 0.668362307388384 0.541666666666667 24.2 24 2 abnormal stomach morphology 0.230741787825258 0.501311364021673 0.66440750083579 0.538461538461538 24.2 24 2 abnormal ureter morphology 0.230741787825258 0.501311364021673 0.66440750083579 0.538461538461538 24.2 24 2 short premaxilla 0.349756791145502 0.634125063554901 0.66440750083579 0.538461538461538 24.2 24 2 pup cannibalization 0.349756791145502 0.634125063554901 0.66440750083579 0.538461538461538 24.2 24 2 abnormal intercostal muscle morphology 0.349756791145502 0.634125063554901 0.66440750083579 0.538461538461538 24.2 24 2 increased synaptic depression 0.349756791145502 0.634125063554901 0.66440750083579 0.538461538461538 24.2 24 2 abnormal bile duct development 0.349756791145502 0.634125063554901 0.66440750083579 0.538461538461538 24.2 24 2 vestibular hair cell degeneration 0.349756791145502 0.634125063554901 0.66440750083579 0.538461538461538 24.2 24 2 small interparietal bone 0.349756791145502 0.634125063554901 0.66440750083579 0.538461538461538 24.2 24 2 increased circulating ammonia level 0.349756791145502 0.634125063554901 0.66440750083579 0.538461538461538 24.2 24 2 increased renin activity 0.349756791145502 0.634125063554901 0.66440750083579 0.538461538461538 24.2 24 2 abnormal lens fiber morphology 0.163486714072545 0.426282181609493 0.66440750083579 0.538461538461538 24.2 24 2 abnormal cochlea morphology 0.118217448883268 0.344339466155888 0.662649809034637 0.537037037037037 24.2 24 2 short ulna 0.161356441610199 0.423082517410697 0.662092492122076 0.536585365853659 24.2 24 2 abnormal food intake 0.0872365120441642 0.270948434330732 0.661656331060072 0.536231884057971 24.2 24 2 abnormal eye development 0.116875555116215 0.340829945312527 0.661017666647852 0.535714285714286 24.2 24 2 myoclonus 0.226811980828365 0.501311364021673 0.661017666647852 0.535714285714286 24.2 24 2 abnormal jaw morphology 0.226811980828365 0.501311364021673 0.661017666647852 0.535714285714286 24.2 24 2 abnormal respiration 0.226811980828365 0.501311364021673 0.661017666647852 0.535714285714286 24.2 24 2 absent corpus callosum 0.226811980828365 0.501311364021673 0.661017666647852 0.535714285714286 24.2 24 2 abnormal hormone level 0.226811980828365 0.501311364021673 0.661017666647852 0.535714285714286 24.2 24 2 increased food intake 0.0652164936573618 0.231308004962795 0.661017666647852 0.535714285714286 24.2 24 2 abnormal CNS synaptic transmission 0.0492003349401619 0.181665204784283 0.660572536906002 0.535353535353535 24.2 24 2 abnormal blood circulation 0.159205378370433 0.41929420719582 0.65999283305615 0.534883720930233 24.2 24 2 abnormal eye physiology 0.114149983357905 0.334253188467084 0.65807981035164 0.533333333333333 24.2 24 2 emphysema 0.222912862226732 0.49864725250809 0.65807981035164 0.533333333333333 24.2 24 2 abnormal pain threshold 0.222912862226732 0.49864725250809 0.65807981035164 0.533333333333333 24.2 24 2 abnormal enteric neuron morphology 0.339598800585913 0.634125063554901 0.65807981035164 0.533333333333333 24.2 24 2 abnormal epidermis stratum spinosum morphology 0.339598800585913 0.634125063554901 0.65807981035164 0.533333333333333 24.2 24 2 abnormal pup retrieval 0.339598800585913 0.634125063554901 0.65807981035164 0.533333333333333 24.2 24 2 no suckling reflex 0.339598800585913 0.634125063554901 0.65807981035164 0.533333333333333 24.2 24 2 abnormal respiratory system morphology 0.339598800585913 0.634125063554901 0.65807981035164 0.533333333333333 24.2 24 2 abnormal cricoid cartilage morphology 0.339598800585913 0.634125063554901 0.65807981035164 0.533333333333333 24.2 24 2 abnormal bronchus morphology 0.339598800585913 0.634125063554901 0.65807981035164 0.533333333333333 24.2 24 2 dilated ureter 0.339598800585913 0.634125063554901 0.65807981035164 0.533333333333333 24.2 24 2 decreased aggression towards males 0.339598800585913 0.634125063554901 0.65807981035164 0.533333333333333 24.2 24 2 abnormal aorta wall morphology 0.339598800585913 0.634125063554901 0.65807981035164 0.533333333333333 24.2 24 2 lactation failure 0.339598800585913 0.634125063554901 0.65807981035164 0.533333333333333 24.2 24 2 herniated liver 0.339598800585913 0.634125063554901 0.65807981035164 0.533333333333333 24.2 24 2 abnormal branching involved in lung morphogenesis 0.339598800585913 0.634125063554901 0.65807981035164 0.533333333333333 24.2 24 2 abnormal lymphatic vessel morphology 0.219058501382298 0.490466266596278 0.655509186092454 0.53125 24.2 24 2 increased dopamine level 0.219058501382298 0.490466266596278 0.655509186092454 0.53125 24.2 24 2 abnormal diaphragm morphology 0.219058501382298 0.490466266596278 0.655509186092454 0.53125 24.2 24 2 absent kidney 0.152713547519783 0.402409904084173 0.654722260298825 0.530612244897959 24.2 24 2 abnormal tail morphology 0.110014066274128 0.322332143529908 0.654340720520096 0.53030303030303 24.2 24 2 abnormal vision 0.215258515231163 0.48260978516225 0.653240988216701 0.529411764705882 24.2 24 2 abnormal bone remodeling 0.215258515231163 0.48260978516225 0.653240988216701 0.529411764705882 24.2 24 2 decreased pancreatic beta cell number 0.215258515231163 0.48260978516225 0.653240988216701 0.529411764705882 24.2 24 2 hydroureter 0.330179339839564 0.634125063554901 0.653240988216701 0.529411764705882 24.2 24 2 abnormal cranial suture morphology 0.330179339839564 0.634125063554901 0.653240988216701 0.529411764705882 24.2 24 2 absence seizures 0.330179339839564 0.634125063554901 0.653240988216701 0.529411764705882 24.2 24 2 abnormal duodenum morphology 0.330179339839564 0.634125063554901 0.653240988216701 0.529411764705882 24.2 24 2 aminoaciduria 0.330179339839564 0.634125063554901 0.653240988216701 0.529411764705882 24.2 24 2 decreased growth hormone level 0.330179339839564 0.634125063554901 0.653240988216701 0.529411764705882 24.2 24 2 abnormal retinal outer nuclear layer morphology 0.207845363449806 0.466620344387538 0.649420865478592 0.526315789473684 24.2 24 2 enlarged adrenal glands 0.321380025139708 0.620677649483714 0.649420865478592 0.526315789473684 24.2 24 2 thin dermal layer 0.321380025139708 0.620677649483714 0.649420865478592 0.526315789473684 24.2 24 2 stereotypic behavior 0.321380025139708 0.620677649483714 0.649420865478592 0.526315789473684 24.2 24 2 abnormal long term depression 0.321380025139708 0.620677649483714 0.649420865478592 0.526315789473684 24.2 24 2 delayed sexual maturation 0.321380025139708 0.620677649483714 0.649420865478592 0.526315789473684 24.2 24 2 abnormal neurotransmitter level 0.321380025139708 0.620677649483714 0.649420865478592 0.526315789473684 24.2 24 2 abnormal nasal septum morphology 0.321380025139708 0.620677649483714 0.649420865478592 0.526315789473684 24.2 24 2 abnormal response to novelty 0.321380025139708 0.620677649483714 0.649420865478592 0.526315789473684 24.2 24 2 abnormal sternebra morphology 0.321380025139708 0.620677649483714 0.649420865478592 0.526315789473684 24.2 24 2 abnormal cochlear inner hair cell morphology 0.321380025139708 0.620677649483714 0.649420865478592 0.526315789473684 24.2 24 2 Leydig cell hypoplasia 0.321380025139708 0.620677649483714 0.649420865478592 0.526315789473684 24.2 24 2 decreased liver glycogen level 0.321380025139708 0.620677649483714 0.649420865478592 0.526315789473684 24.2 24 2 abnormal stapes morphology 0.313111685984254 0.607539250300961 0.646328385166789 0.523809523809524 24.2 24 2 increased keratinocyte proliferation 0.313111685984254 0.607539250300961 0.646328385166789 0.523809523809524 24.2 24 2 renal interstitial fibrosis 0.197234798272924 0.450066035014833 0.644992995941238 0.522727272727273 24.2 24 2 abnormal amino acid level 0.197234798272924 0.450066035014833 0.644992995941238 0.522727272727273 24.2 24 2 abnormal cochlear ganglion morphology 0.305305117803578 0.592854395422638 0.643773727517908 0.521739130434783 24.2 24 2 abnormal cardiovascular development 0.305305117803578 0.592854395422638 0.643773727517908 0.521739130434783 24.2 24 2 abnormal crista ampullaris morphology 0.305305117803578 0.592854395422638 0.643773727517908 0.521739130434783 24.2 24 2 abnormal regulatory T cell physiology 0.305305117803578 0.592854395422638 0.643773727517908 0.521739130434783 24.2 24 2 abnormal phalanx morphology 0.190509399009398 0.450066035014833 0.642656064796523 0.520833333333333 24.2 24 2 increased body length 0.187249983334381 0.450066035014833 0.641627815092849 0.52 24.2 24 2 abnormal nest building behavior 0.297905292862215 0.579389691942737 0.641627815092849 0.52 24.2 24 2 abnormal feces composition 0.297905292862215 0.579389691942737 0.641627815092849 0.52 24.2 24 2 diaphragmatic hernia 0.297905292862215 0.579389691942737 0.641627815092849 0.52 24.2 24 2 decreased body temperature 0.18405813801514 0.450066035014833 0.640678661520226 0.519230769230769 24.2 24 2 decreased susceptibility to pharmacologically induced seizures 0.290867568810907 0.5663664011093 0.63979981561965 0.518518518518518 24.2 24 2 circling 0.117178657579794 0.341513662249252 0.638724521811886 0.517647058823529 24.2 24 2 abnormal middle ear morphology 0.284155111632656 0.553512795760557 0.638223954004823 0.517241379310345 24.2 24 2 absent mature ovarian follicles 0.277737088681991 0.541222881391658 0.636851429372555 0.516129032258065 24.2 24 2 abnormal retinal photoreceptor layer morphology 0.277737088681991 0.541222881391658 0.636851429372555 0.516129032258065 24.2 24 2 decreased neuronal precursor cell number 0.277737088681991 0.541222881391658 0.636851429372555 0.516129032258065 24.2 24 2 abnormal intestine physiology 0.277737088681991 0.541222881391658 0.636851429372555 0.516129032258065 24.2 24 2 dilated heart atrium 0.271587367742285 0.530277533170278 0.635645271362379 0.515151515151515 24.2 24 2 head tossing 0.271587367742285 0.530277533170278 0.635645271362379 0.515151515151515 24.2 24 2 abnormal intestinal mucosa morphology 0.244174698847635 0.501311364021673 0.631297492488492 0.511627906976744 24.2 24 2 abnormal autopod morphology 0.239253490853498 0.501311364021673 0.630659818253655 0.511111111111111 24.2 24 2 abnormal innervation 0.234491759827225 0.501311364021673 0.630076414166463 0.51063829787234 24.2 24 2 increased susceptibility to pharmacologically induced seizures 0.128174214745353 0.350071857866991 0.629802943500593 0.510416666666667 24.2 24 2 abnormal malleus morphology 0.375928447058133 0.634125063554901 0.616949822204662 0.5 24.2 24 2 abnormal adipose tissue distribution 0.4664071691757 0.65807591226577 0.616949822204662 0.5 24.2 24 2 abnormal glossopharyngeal nerve morphology 0.4664071691757 0.65807591226577 0.616949822204662 0.5 24.2 24 2 abnormal alisphenoid bone morphology 0.4664071691757 0.65807591226577 0.616949822204662 0.5 24.2 24 2 decreased left ventricle systolic pressure 0.4664071691757 0.65807591226577 0.616949822204662 0.5 24.2 24 2 small parietal bone 0.4664071691757 0.65807591226577 0.616949822204662 0.5 24.2 24 2 abnormal patella morphology 0.4664071691757 0.65807591226577 0.616949822204662 0.5 24.2 24 2 decreased compensatory feeding amount 0.4664071691757 0.65807591226577 0.616949822204662 0.5 24.2 24 2 abnormal colon goblet cell morphology 0.4664071691757 0.65807591226577 0.616949822204662 0.5 24.2 24 2 abnormal digestive system physiology 0.272510171954446 0.531870578844005 0.616949822204662 0.5 24.2 24 2 abnormal stria vascularis morphology 0.354923156793448 0.634125063554901 0.616949822204662 0.5 24.2 24 2 abnormal stomach glandular epithelium morphology 0.414174149584296 0.634125063554901 0.616949822204662 0.5 24.2 24 2 thick dermal layer 0.414174149584296 0.634125063554901 0.616949822204662 0.5 24.2 24 2 mixed cellular infiltration to dermis 0.429518585210696 0.634125063554901 0.616949822204662 0.5 24.2 24 2 abnormal pinna reflex 0.446732427371755 0.634125063554901 0.616949822204662 0.5 24.2 24 2 abnormal placing response 0.446732427371755 0.634125063554901 0.616949822204662 0.5 24.2 24 2 extended life span 0.446732427371755 0.634125063554901 0.616949822204662 0.5 24.2 24 2 abnormal intestinal absorption 0.429518585210696 0.634125063554901 0.616949822204662 0.5 24.2 24 2 abnormal thyroid cartilage morphology 0.414174149584296 0.634125063554901 0.616949822204662 0.5 24.2 24 2 abnormal ocular fundus morphology 0.365068797899172 0.634125063554901 0.616949822204662 0.5 24.2 24 2 abnormal endplate potential 0.446732427371755 0.634125063554901 0.616949822204662 0.5 24.2 24 2 acidosis 0.414174149584296 0.634125063554901 0.616949822204662 0.5 24.2 24 2 abnormal epicardium morphology 0.429518585210696 0.634125063554901 0.616949822204662 0.5 24.2 24 2 intestinal obstruction 0.446732427371755 0.634125063554901 0.616949822204662 0.5 24.2 24 2 abnormal hair cuticle 0.446732427371755 0.634125063554901 0.616949822204662 0.5 24.2 24 2 enlarged stomach 0.446732427371755 0.634125063554901 0.616949822204662 0.5 24.2 24 2 abnormal squamosal bone morphology 0.446732427371755 0.634125063554901 0.616949822204662 0.5 24.2 24 2 decreased circulating progesterone level 0.354923156793448 0.634125063554901 0.616949822204662 0.5 24.2 24 2 abnormal pancreatic alpha cell morphology 0.429518585210696 0.634125063554901 0.616949822204662 0.5 24.2 24 2 abnormal glucose tolerance 0.446732427371755 0.634125063554901 0.616949822204662 0.5 24.2 24 2 spina bifida occulta 0.446732427371755 0.634125063554901 0.616949822204662 0.5 24.2 24 2 decreased pulmonary respiratory rate 0.414174149584296 0.634125063554901 0.616949822204662 0.5 24.2 24 2 abnormal metanephric mesenchyme morphology 0.414174149584296 0.634125063554901 0.616949822204662 0.5 24.2 24 2 decreased adipocyte glucose uptake 0.429518585210696 0.634125063554901 0.616949822204662 0.5 24.2 24 2 increased body size 0.387621335325831 0.634125063554901 0.616949822204662 0.5 24.2 24 2 testis hypoplasia 0.387621335325831 0.634125063554901 0.616949822204662 0.5 24.2 24 2 increased coping response 0.387621335325831 0.634125063554901 0.616949822204662 0.5 24.2 24 2 abnormal heart right ventricle morphology 0.400301694826229 0.634125063554901 0.616949822204662 0.5 24.2 24 2 abnormal incus morphology 0.400301694826229 0.634125063554901 0.616949822204662 0.5 24.2 24 2 failure of palatal shelf elevation 0.387621335325831 0.634125063554901 0.616949822204662 0.5 24.2 24 2 abnormal circulating cytokine level 0.400301694826229 0.634125063554901 0.616949822204662 0.5 24.2 24 2 abnormal heart electrocardiography waveform feature 0.400301694826229 0.634125063554901 0.616949822204662 0.5 24.2 24 2 abnormal lateral semicircular canal morphology 0.489478385992992 0.686732930150912 0.616949822204662 0.5 24.2 24 2 jaundice 0.489478385992992 0.686732930150912 0.616949822204662 0.5 24.2 24 2 abnormal gland morphology 0.489478385992992 0.686732930150912 0.616949822204662 0.5 24.2 24 2 abnormal respiratory mechanics 0.489478385992992 0.686732930150912 0.616949822204662 0.5 24.2 24 2 decreased circulating parathyroid hormone level 0.489478385992992 0.686732930150912 0.616949822204662 0.5 24.2 24 2 abnormal neuron specification 0.489478385992992 0.686732930150912 0.616949822204662 0.5 24.2 24 2 abnormal primordial germ cell migration 0.489478385992992 0.686732930150912 0.616949822204662 0.5 24.2 24 2 primary sex reversal 0.489478385992992 0.686732930150912 0.616949822204662 0.5 24.2 24 2 delayed dark adaptation 0.489478385992992 0.686732930150912 0.616949822204662 0.5 24.2 24 2 intestinal edema 0.489478385992992 0.686732930150912 0.616949822204662 0.5 24.2 24 2 abnormal hindlimb zeugopod morphology 0.489478385992992 0.686732930150912 0.616949822204662 0.5 24.2 24 2 increased defecation amount 0.489478385992992 0.686732930150912 0.616949822204662 0.5 24.2 24 2 abnormal utricular macula morphology 0.489478385992992 0.686732930150912 0.616949822204662 0.5 24.2 24 2 abnormal respiratory conducting tube morphology 0.489478385992992 0.686732930150912 0.616949822204662 0.5 24.2 24 2 absent coat pigmentation 0.489478385992992 0.686732930150912 0.616949822204662 0.5 24.2 24 2 abnormal sperm principal piece morphology 0.489478385992992 0.686732930150912 0.616949822204662 0.5 24.2 24 2 abnormal retinal blood vessel pattern 0.489478385992992 0.686732930150912 0.616949822204662 0.5 24.2 24 2 increased T-helper 17 cell number 0.489478385992992 0.686732930150912 0.616949822204662 0.5 24.2 24 2 increased white adipose tissue amount 0.37653961867207 0.634125063554901 0.600275502685617 0.486486486486487 24.2 24 2 diarrhea 0.397430554324648 0.634125063554901 0.598254373046945 0.484848484848485 24.2 24 2 abnormal brain commissure morphology 0.433969939195419 0.634125063554901 0.594099828789675 0.481481481481481 24.2 24 2 abnormal stomach mucosa morphology 0.447949820162057 0.634372432481137 0.592271829316476 0.48 24.2 24 2 abnormal carpal bone morphology 0.463077868054562 0.654864239218717 0.590125916891416 0.478260869565217 24.2 24 2 abnormal retinal cone cell morphology 0.463077868054562 0.654864239218717 0.590125916891416 0.478260869565217 24.2 24 2 abnormal corneal stroma morphology 0.463077868054562 0.654864239218717 0.590125916891416 0.478260869565217 24.2 24 2 decreased vocalization 0.479565339228025 0.676257812545188 0.587571259242535 0.476190476190476 24.2 24 2 decreased chemically-elicited antinociception 0.497688861584427 0.697268962653484 0.584478778930733 0.473684210526316 24.2 24 2 abnormal ear morphology 0.497688861584427 0.697268962653484 0.584478778930733 0.473684210526316 24.2 24 2 maternal imprinting 0.497688861584427 0.697268962653484 0.584478778930733 0.473684210526316 24.2 24 2 osteoarthritis 0.497688861584427 0.697268962653484 0.584478778930733 0.473684210526316 24.2 24 2 abnormal reflex 0.446499104640315 0.634125063554901 0.582674832082181 0.472222222222222 24.2 24 2 abnormal inhibitory postsynaptic currents 0.396490967360741 0.634125063554901 0.580658656192623 0.470588235294118 24.2 24 2 increased susceptibility to weight gain 0.459221073499083 0.64996439279031 0.580658656192623 0.470588235294118 24.2 24 2 increased aggression towards mice 0.517820136651704 0.718392409325775 0.580658656192623 0.470588235294118 24.2 24 2 abnormal electroretinogram waveform feature 0.517820136651704 0.718392409325775 0.580658656192623 0.470588235294118 24.2 24 2 abnormal long term potentiation 0.472722857894526 0.666797907010282 0.578390458316871 0.46875 24.2 24 2 interdigital webbing 0.540474350809367 0.747944338046342 0.575819834057685 0.466666666666667 24.2 24 2 decreased salivation 0.540474350809367 0.747944338046342 0.575819834057685 0.466666666666667 24.2 24 2 abnormal apical ectodermal ridge morphology 0.540474350809367 0.747944338046342 0.575819834057685 0.466666666666667 24.2 24 2 abnormal zygomatic bone morphology 0.540474350809367 0.747944338046342 0.575819834057685 0.466666666666667 24.2 24 2 abnormal Muller cell morphology 0.540474350809367 0.747944338046342 0.575819834057685 0.466666666666667 24.2 24 2 ostium primum atrial septal defect 0.540474350809367 0.747944338046342 0.575819834057685 0.466666666666667 24.2 24 2 abnormal femur morphology 0.448712112806863 0.635271132957923 0.570908790696852 0.462686567164179 24.2 24 2 abnormal tectorial membrane morphology 0.518990696387387 0.719815643860399 0.569492143573534 0.461538461538462 24.2 24 2 dystrophic cardiac calcinosis 0.566393207487297 0.770313342605059 0.569492143573534 0.461538461538462 24.2 24 2 absent lateral semicircular canal 0.566393207487297 0.770313342605059 0.569492143573534 0.461538461538462 24.2 24 2 abnormal GABAergic neuron morphology 0.566393207487297 0.770313342605059 0.569492143573534 0.461538461538462 24.2 24 2 abnormal retinal inner plexiform layer morphology 0.566393207487297 0.770313342605059 0.569492143573534 0.461538461538462 24.2 24 2 decreased luteinizing hormone level 0.566393207487297 0.770313342605059 0.569492143573534 0.461538461538462 24.2 24 2 hyperalgesia 0.566393207487297 0.770313342605059 0.569492143573534 0.461538461538462 24.2 24 2 abnormal gut flora balance 0.566393207487297 0.770313342605059 0.569492143573534 0.461538461538462 24.2 24 2 abnormal humerus morphology 0.505964667713323 0.708663913815817 0.566926863647527 0.459459459459459 24.2 24 2 abnormal osteoblast morphology 0.536819685820771 0.744128709099564 0.56553733702094 0.458333333333333 24.2 24 2 abnormal middle ear ossicle morphology 0.535466444202757 0.742459743564303 0.560863474731511 0.454545454545455 24.2 24 2 obese 0.495554623487335 0.695061813320974 0.560863474731511 0.454545454545455 24.2 24 2 abnormal tracheal cartilage morphology 0.556185342479854 0.757880602256169 0.560863474731511 0.454545454545455 24.2 24 2 abnormal temporal bone morphology 0.556185342479854 0.757880602256169 0.560863474731511 0.454545454545455 24.2 24 2 increased mast cell number 0.596696597400456 0.797552684506382 0.560863474731511 0.454545454545455 24.2 24 2 enlarged cranium 0.596696597400456 0.797552684506382 0.560863474731511 0.454545454545455 24.2 24 2 abnormal glossopharyngeal ganglion morphology 0.596696597400456 0.797552684506382 0.560863474731511 0.454545454545455 24.2 24 2 abnormal primary sex determination 0.596696597400456 0.797552684506382 0.560863474731511 0.454545454545455 24.2 24 2 abnormal larynx morphology 0.596696597400456 0.797552684506382 0.560863474731511 0.454545454545455 24.2 24 2 allodynia 0.596696597400456 0.797552684506382 0.560863474731511 0.454545454545455 24.2 24 2 rectal hemorrhage 0.596696597400456 0.797552684506382 0.560863474731511 0.454545454545455 24.2 24 2 abnormal lymph circulation 0.596696597400456 0.797552684506382 0.560863474731511 0.454545454545455 24.2 24 2 abnormal ureter development 0.596696597400456 0.797552684506382 0.560863474731511 0.454545454545455 24.2 24 2 enlarged placenta 0.596696597400456 0.797552684506382 0.560863474731511 0.454545454545455 24.2 24 2 increased motor neuron number 0.596696597400456 0.797552684506382 0.560863474731511 0.454545454545455 24.2 24 2 abnormal Bruch membrane morphology 0.596696597400456 0.797552684506382 0.560863474731511 0.454545454545455 24.2 24 2 increased circulating triiodothyronine level 0.596696597400456 0.797552684506382 0.560863474731511 0.454545454545455 24.2 24 2 shortened PR interval 0.596696597400456 0.797552684506382 0.560863474731511 0.454545454545455 24.2 24 2 increased susceptibility to weight loss 0.54908804910142 0.754946756134828 0.555254839984196 0.45 24.2 24 2 abnormal hearing physiology 0.577369270750225 0.784169293470481 0.555254839984196 0.45 24.2 24 2 abnormal fibula morphology 0.577369270750225 0.784169293470481 0.555254839984196 0.45 24.2 24 2 enhanced behavioral response to xenobiotic 0.577369270750225 0.784169293470481 0.555254839984196 0.45 24.2 24 2 nuclear cataracts 0.577369270750225 0.784169293470481 0.555254839984196 0.45 24.2 24 2 increased circulating corticosterone level 0.574482153776643 0.781101042645203 0.5483998419597 0.444444444444444 24.2 24 2 wrinkled skin 0.587007302140962 0.796824373301851 0.5483998419597 0.444444444444444 24.2 24 2 abnormal single cell response 0.587007302140962 0.796824373301851 0.5483998419597 0.444444444444444 24.2 24 2 abnormal serotonin level 0.612882733135667 0.807492478111744 0.539831094429079 0.4375 24.2 24 2 abnormal tympanic ring morphology 0.626773279608331 0.824919858743769 0.539831094429079 0.4375 24.2 24 2 abnormal epididymis epithelium morphology 0.626773279608331 0.824919858743769 0.539831094429079 0.4375 24.2 24 2 impaired behavioral response to addictive substance 0.626773279608331 0.824919858743769 0.539831094429079 0.4375 24.2 24 2 decreased skeletal muscle weight 0.626773279608331 0.824919858743769 0.539831094429079 0.4375 24.2 24 2 abnormal innervation pattern to muscle 0.627806476653155 0.825624430702999 0.536478106264924 0.434782608695652 24.2 24 2 blistering 0.627806476653155 0.825624430702999 0.536478106264924 0.434782608695652 24.2 24 2 abnormal palatal shelf fusion at midline 0.627806476653155 0.825624430702999 0.536478106264924 0.434782608695652 24.2 24 2 abnormal estrous cycle 0.631096476338883 0.827662633786906 0.534689845910707 0.433333333333333 24.2 24 2 abnormal interparietal bone morphology 0.656138792573955 0.844042524133732 0.528814133318282 0.428571428571429 24.2 24 2 abnormal zigzag hair morphology 0.656138792573955 0.844042524133732 0.528814133318282 0.428571428571429 24.2 24 2 abnormal olfactory system physiology 0.656138792573955 0.844042524133732 0.528814133318282 0.428571428571429 24.2 24 2 decreased vascular permeability 0.656138792573955 0.844042524133732 0.528814133318282 0.428571428571429 24.2 24 2 skeletal muscle necrosis 0.656138792573955 0.844042524133732 0.528814133318282 0.428571428571429 24.2 24 2 increased circulating growth hormone level 0.656138792573955 0.844042524133732 0.528814133318282 0.428571428571429 24.2 24 2 sternebra fusion 0.656138792573955 0.844042524133732 0.528814133318282 0.428571428571429 24.2 24 2 hypoalgesia 0.650722219391875 0.844042524133732 0.528814133318282 0.428571428571429 24.2 24 2 head bobbing 0.670763936497803 0.844042524133732 0.524407348873963 0.425 24.2 24 2 increased percent body fat/body weight 0.688574385401233 0.844042524133732 0.522034464942406 0.423076923076923 24.2 24 2 decreased grooming behavior 0.675680973375597 0.844042524133732 0.519536692382873 0.421052631578947 24.2 24 2 abnormal photoreceptor inner segment morphology 0.675680973375597 0.844042524133732 0.519536692382873 0.421052631578947 24.2 24 2 abnormal behavioral response to xenobiotic 0.675680973375597 0.844042524133732 0.519536692382873 0.421052631578947 24.2 24 2 abnormal body temperature homeostasis 0.688537473676427 0.844042524133732 0.517441786365201 0.419354838709677 24.2 24 2 decreased digestive secretion 0.689760474703854 0.844042524133732 0.514124851837219 0.416666666666667 24.2 24 2 abnormal superior cervical ganglion morphology 0.689760474703854 0.844042524133732 0.514124851837219 0.416666666666667 24.2 24 2 increased litter size 0.689760474703854 0.844042524133732 0.514124851837219 0.416666666666667 24.2 24 2 absent tail 0.689760474703854 0.844042524133732 0.514124851837219 0.416666666666667 24.2 24 2 decreased renal glomerular filtration rate 0.689760474703854 0.844042524133732 0.514124851837219 0.416666666666667 24.2 24 2 abnormal tendon morphology 0.70304047967797 0.853495945924329 0.508076324168545 0.411764705882353 24.2 24 2 common atrium 0.70304047967797 0.853495945924329 0.508076324168545 0.411764705882353 24.2 24 2 intestinal ulcer 0.716170826484813 0.869224167299815 0.50477712725836 0.409090909090909 24.2 24 2 polyphagia 0.767089511648326 0.914734017365873 0.502699855129725 0.407407407407407 24.2 24 2 impaired behavioral response to xenobiotic 0.768400155471494 0.915857875771606 0.49355985776373 0.4 24.2 24 2 increased urine calcium level 0.741222108459179 0.885585972522674 0.49355985776373 0.4 24.2 24 2 single kidney 0.786044947412648 0.931310696208127 0.486081678100643 0.393939393939394 24.2 24 2 decreased epididymis weight 0.772976479948022 0.91944951703327 0.482830295638431 0.391304347826087 24.2 24 2 abnormal anterior eye segment morphology 0.768142740914913 0.915770461550849 0.479849861714737 0.388888888888889 24.2 24 2 abnormal renal/urinary system morphology 0.766865016714202 0.914685556977501 0.474576786311279 0.384615384615385 24.2 24 2 small trigeminal ganglion 0.766865016714202 0.914685556977501 0.474576786311279 0.384615384615385 24.2 24 2 anal atresia 0.766865016714202 0.914685556977501 0.474576786311279 0.384615384615385 24.2 24 2 abnormal dopaminergic neuron morphology 0.766865016714202 0.914685556977501 0.474576786311279 0.384615384615385 24.2 24 2 tracheoesophageal fistula 0.766865016714202 0.914685556977501 0.474576786311279 0.384615384615385 24.2 24 2 abnormal afterhyperpolarization 0.766865016714202 0.914685556977501 0.474576786311279 0.384615384615385 24.2 24 2 decreased alcohol consumption 0.766865016714202 0.914685556977501 0.474576786311279 0.384615384615385 24.2 24 2 abnormal pituitary gland morphology 0.797133504902225 0.94422361592585 0.462712366653497 0.375 24.2 24 2 syndactyly 0.901689132937593 1 0.460098172491613 0.372881355932203 24.2 24 2 abnormal axon guidance 0.875526557918203 0.999043377431725 0.459125449082539 0.372093023255814 24.2 24 2 impaired conditioned place preference behavior 0.860939000309248 0.984184633855356 0.444203871987357 0.36 24.2 24 2 decreased cornea thickness 0.828379585681006 0.95637056399443 0.440678444431902 0.357142857142857 24.2 24 2 increased circulating luteinizing hormone level 0.876349014840047 0.999274890861617 0.440678444431902 0.357142857142857 24.2 24 2 distended urinary bladder 0.848456973206364 0.970138690347429 0.435493992144467 0.352941176470588 24.2 24 2 decreased skin tensile strength 0.865616975413539 0.988169906535649 0.431864875543263 0.35 24.2 24 2 increased susceptibility to age related obesity 0.880427915250159 1 0.429182485011939 0.347826086956522 24.2 24 2 altered righting response 0.875945168313002 0.999043377431725 0.411299881469775 0.333333333333333 24.2 24 2 increased alcohol consumption 0.875945168313002 0.999043377431725 0.411299881469775 0.333333333333333 24.2 24 2 greasy coat 0.875945168313002 0.999043377431725 0.411299881469775 0.333333333333333 24.2 24 2 increased vasoconstriction 0.899968289177703 1 0.411299881469775 0.333333333333333 24.2 24 2 abnormal urinary bladder morphology 0.93814851771286 1 0.36291166012039 0.294117647058824 24.2 24 2 enlarged sebaceous gland 0.93814851771286 1 0.36291166012039 0.294117647058824 24.2 24 2 abnormal radial glial cell morphology 4.4297142153801e-07 1.50944028914493e-05 2.77941176470588 1 25.1 25 1 abnormal lambdoidal suture morphology 0.000342705337622546 0.00430545215826304 2.77941176470588 1 25.1 25 1 abnormal aorta tunica adventitia morphology 0.000342705337622546 0.00430545215826304 2.77941176470588 1 25.1 25 1 abnormal olfactory bulb layer morphology 0.000342705337622546 0.00430545215826304 2.77941176470588 1 25.1 25 1 decreased sensitivity to skin irradiation 0.00129575547283682 0.0121629876931381 2.77941176470588 1 25.1 25 1 ischuria 0.00129575547283682 0.0121629876931381 2.77941176470588 1 25.1 25 1 abnormal hypodermis morphology 0.00129575547283682 0.0121629876931381 2.77941176470588 1 25.1 25 1 increased placenta apoptosis 0.00129575547283682 0.0121629876931381 2.77941176470588 1 25.1 25 1 increased mammary gland epithelial cell proliferation 0.00129575547283682 0.0121629876931381 2.77941176470588 1 25.1 25 1 increased thyroid carcinoma incidence 0.00129575547283682 0.0121629876931381 2.77941176470588 1 25.1 25 1 inlet ventricular septal defect 0.00129575547283682 0.0121629876931381 2.77941176470588 1 25.1 25 1 increased Schwann cell number 0.00129575547283682 0.0121629876931381 2.77941176470588 1 25.1 25 1 abnormal cerebellum deep nucleus morphology 2.39667788446863e-05 0.000478854316274354 2.77941176470588 1 25.1 25 1 decreased collagen level 9.06323155396615e-05 0.00142238413189216 2.77941176470588 1 25.1 25 1 premature suture closure 1.40012762698352e-05 0.000315187101549458 2.52673796791444 0.909090909090909 25.1 25 1 decreased atrioventricular cushion size 1.40012762698352e-05 0.000315187101549458 2.52673796791444 0.909090909090909 25.1 25 1 fused cornea and lens 4.82925697043955e-05 0.000883292405438851 2.50147058823529 0.9 25.1 25 1 abnormal thymus physiology 0.000165003032793792 0.00234540025185461 2.47058823529412 0.888888888888889 25.1 25 1 eye opacity 0.000165003032793792 0.00234540025185461 2.47058823529412 0.888888888888889 25.1 25 1 binucleate 0.000557291072404487 0.00625328880547906 2.43198529411765 0.875 25.1 25 1 tau protein deposits 0.000557291072404487 0.00625328880547906 2.43198529411765 0.875 25.1 25 1 abnormal olfactory bulb mitral cell layer morphology 0.000557291072404487 0.00625328880547906 2.43198529411765 0.875 25.1 25 1 decreased alveolar lamellar body number 0.000557291072404487 0.00625328880547906 2.43198529411765 0.875 25.1 25 1 abnormal bronchiole epithelium morphology 0.000557291072404487 0.00625328880547906 2.43198529411765 0.875 25.1 25 1 abnormal foramen magnum morphology 0.000557291072404487 0.00625328880547906 2.43198529411765 0.875 25.1 25 1 abnormal heart echocardiography feature 0.000557291072404487 0.00625328880547906 2.43198529411765 0.875 25.1 25 1 abnormal sagittal suture morphology 6.0941408844534e-06 0.000157908077604977 2.38235294117647 0.857142857142857 25.1 25 1 abnormal tumor incidence 0.00185514347011985 0.0161631730918978 2.38235294117647 0.857142857142857 25.1 25 1 abnormal brain ventricular system morphology 0.00185514347011985 0.0161631730918978 2.38235294117647 0.857142857142857 25.1 25 1 abnormal tricarboxylic acid cycle 0.00185514347011985 0.0161631730918978 2.38235294117647 0.857142857142857 25.1 25 1 abnormal aorta elastic tissue morphology 6.38699152947624e-05 0.00109193411887094 2.31617647058824 0.833333333333333 25.1 25 1 abnormal lens induction 0.0060610061489082 0.0395715296467432 2.31617647058824 0.833333333333333 25.1 25 1 increased embryo size 0.0060610061489082 0.0395715296467432 2.31617647058824 0.833333333333333 25.1 25 1 abnormal physical strength 0.0060610061489082 0.0395715296467432 2.31617647058824 0.833333333333333 25.1 25 1 delayed chorioallantoic fusion 0.0060610061489082 0.0395715296467432 2.31617647058824 0.833333333333333 25.1 25 1 abnormal heart right ventricle outflow tract morphology 0.0060610061489082 0.0395715296467432 2.31617647058824 0.833333333333333 25.1 25 1 persistent hyperplastic primary vitreous 0.0060610061489082 0.0395715296467432 2.31617647058824 0.833333333333333 25.1 25 1 abnormal ureteric bud elongation 0.0060610061489082 0.0395715296467432 2.31617647058824 0.833333333333333 25.1 25 1 thymus cortex atrophy 0.0060610061489082 0.0395715296467432 2.31617647058824 0.833333333333333 25.1 25 1 patent ductus arteriosus 0.000202603390159916 0.00276909853309226 2.27406417112299 0.818181818181818 25.1 25 1 abnormal aorta smooth muscle morphology 0.000202603390159916 0.00276909853309226 2.27406417112299 0.818181818181818 25.1 25 1 vasculature congestion 7.4593021222473e-06 0.000181911902245982 2.25827205882353 0.8125 25.1 25 1 abnormal immune cell physiology 0.000631844885151378 0.00677462996471574 2.22352941176471 0.8 25.1 25 1 abnormal primordial germ cell migration 0.000631844885151378 0.00677462996471574 2.22352941176471 0.8 25.1 25 1 abnormal developmental vascular remodeling 0.000631844885151378 0.00677462996471574 2.22352941176471 0.8 25.1 25 1 abnormal aorta wall morphology 2.3064630266674e-05 0.000466449331612614 2.22352941176471 0.8 25.1 25 1 sternebra fusion 7.02848040134108e-05 0.00116249859346824 2.18382352941176 0.785714285714286 25.1 25 1 shortened ST segment 0.00193029921104192 0.0166433944106301 2.16176470588235 0.777777777777778 25.1 25 1 decreased platelet dense granule number 0.00193029921104192 0.0166433944106301 2.16176470588235 0.777777777777778 25.1 25 1 abnormal epicardium morphology 6.98806146999544e-05 0.00116249859346824 2.08455882352941 0.75 25.1 25 1 loose skin 6.98806146999544e-05 0.00116249859346824 2.08455882352941 0.75 25.1 25 1 mesocardia 0.000618803814755378 0.00672172266027949 2.08455882352941 0.75 25.1 25 1 hematuria 0.000618803814755378 0.00672172266027949 2.08455882352941 0.75 25.1 25 1 decreased mammary gland epithelial cell proliferation 0.000618803814755378 0.00672172266027949 2.08455882352941 0.75 25.1 25 1 abnormal pulmonary valve cusp morphology 0.000618803814755378 0.00672172266027949 2.08455882352941 0.75 25.1 25 1 prenatal growth retardation 0.000618803814755378 0.00672172266027949 2.08455882352941 0.75 25.1 25 1 failure of vascular branching 0.00574870066326596 0.0379811232400374 2.08455882352941 0.75 25.1 25 1 enlarged pituitary gland 0.00574870066326596 0.0379811232400374 2.08455882352941 0.75 25.1 25 1 abnormal neuron apoptosis 0.00574870066326596 0.0379811232400374 2.08455882352941 0.75 25.1 25 1 bowed fibula 0.00574870066326596 0.0379811232400374 2.08455882352941 0.75 25.1 25 1 small frontal bone 0.00574870066326596 0.0379811232400374 2.08455882352941 0.75 25.1 25 1 abnormal canal of Schlemm morphology 0.00574870066326596 0.0379811232400374 2.08455882352941 0.75 25.1 25 1 abnormal somite size 0.00574870066326596 0.0379811232400374 2.08455882352941 0.75 25.1 25 1 ocular hypertension 0.00574870066326596 0.0379811232400374 2.08455882352941 0.75 25.1 25 1 abnormal ilium morphology 0.00574870066326596 0.0379811232400374 2.08455882352941 0.75 25.1 25 1 decreased hippocampus pyramidal cell number 0.00574870066326596 0.0379811232400374 2.08455882352941 0.75 25.1 25 1 abnormal hepatic vein morphology 0.00574870066326596 0.0379811232400374 2.08455882352941 0.75 25.1 25 1 abnormal pulmonary acinus morphology 0.00574870066326596 0.0379811232400374 2.08455882352941 0.75 25.1 25 1 increased aorta wall thickness 0.00574870066326596 0.0379811232400374 2.08455882352941 0.75 25.1 25 1 lethality during fetal growth through weaning, incomplete penetrance 0.00574870066326596 0.0379811232400374 2.08455882352941 0.75 25.1 25 1 absent hypoglossal canal 0.00574870066326596 0.0379811232400374 2.08455882352941 0.75 25.1 25 1 increased mammary gland apoptosis 0.00574870066326596 0.0379811232400374 2.08455882352941 0.75 25.1 25 1 abnormal lactation 1.11365183368529e-07 4.3313044868419e-06 2.03823529411765 0.733333333333333 25.1 25 1 abnormal fontanelle morphology 0.000200140281816936 0.00275054669071618 2.03823529411765 0.733333333333333 25.1 25 1 abnormal lymph node B cell domain morphology 0.000200140281816936 0.00275054669071618 2.03823529411765 0.733333333333333 25.1 25 1 abnormal placenta size 0.000200140281816936 0.00275054669071618 2.03823529411765 0.733333333333333 25.1 25 1 pulmonary vascular congestion 7.71186844053959e-06 0.00018441014311776 2.02139037433155 0.727272727272727 25.1 25 1 increased adenoma incidence 7.71186844053959e-06 0.00018441014311776 2.02139037433155 0.727272727272727 25.1 25 1 abnormal sphenoid bone morphology 0.00177648887179527 0.015587358266634 2.02139037433155 0.727272727272727 25.1 25 1 abnormal bronchiole morphology 0.00177648887179527 0.015587358266634 2.02139037433155 0.727272727272727 25.1 25 1 loss of cortex neurons 0.00177648887179527 0.015587358266634 2.02139037433155 0.727272727272727 25.1 25 1 abnormal ureter development 0.00177648887179527 0.015587358266634 2.02139037433155 0.727272727272727 25.1 25 1 abnormal coronal suture morphology 0.00177648887179527 0.015587358266634 2.02139037433155 0.727272727272727 25.1 25 1 abnormal palate development 0.00177648887179527 0.015587358266634 2.02139037433155 0.727272727272727 25.1 25 1 abnormal pulmonary alveolar sac morphology 0.00177648887179527 0.015587358266634 2.02139037433155 0.727272727272727 25.1 25 1 abnormal mitral valve morphology 6.52362576809085e-05 0.00110943691706097 2.00735294117647 0.722222222222222 25.1 25 1 abnormal clavicle morphology 2.14004560498763e-05 0.000435282296276231 1.98529411764706 0.714285714285714 25.1 25 1 vascular ring 2.14004560498763e-05 0.000435282296276231 1.98529411764706 0.714285714285714 25.1 25 1 abnormal vasoconstriction 0.000561406737129354 0.00625328880547906 1.98529411764706 0.714285714285714 25.1 25 1 irregularly shaped pupil 0.000561406737129354 0.00625328880547906 1.98529411764706 0.714285714285714 25.1 25 1 increased aggression towards males 0.000561406737129354 0.00625328880547906 1.98529411764706 0.714285714285714 25.1 25 1 abnormal vascular endothelial cell migration 0.000561406737129354 0.00625328880547906 1.98529411764706 0.714285714285714 25.1 25 1 decreased cornea thickness 0.000561406737129354 0.00625328880547906 1.98529411764706 0.714285714285714 25.1 25 1 broad head 0.0165756628458791 0.0860792512090277 1.98529411764706 0.714285714285714 25.1 25 1 mammary gland hyperplasia 0.0165756628458791 0.0860792512090277 1.98529411764706 0.714285714285714 25.1 25 1 abnormal lacrimal gland morphology 0.0165756628458791 0.0860792512090277 1.98529411764706 0.714285714285714 25.1 25 1 excessive tearing 0.0165756628458791 0.0860792512090277 1.98529411764706 0.714285714285714 25.1 25 1 abnormal gastrulation movements 0.0165756628458791 0.0860792512090277 1.98529411764706 0.714285714285714 25.1 25 1 aorta coarctation 0.0165756628458791 0.0860792512090277 1.98529411764706 0.714285714285714 25.1 25 1 anuria 0.0165756628458791 0.0860792512090277 1.98529411764706 0.714285714285714 25.1 25 1 abnormal nephron morphology 0.0165756628458791 0.0860792512090277 1.98529411764706 0.714285714285714 25.1 25 1 abnormal uterus physiology 0.0165756628458791 0.0860792512090277 1.98529411764706 0.714285714285714 25.1 25 1 abnormal prostaglandin level 0.0165756628458791 0.0860792512090277 1.98529411764706 0.714285714285714 25.1 25 1 arteritis 0.0165756628458791 0.0860792512090277 1.98529411764706 0.714285714285714 25.1 25 1 coronary fistula 0.0165756628458791 0.0860792512090277 1.98529411764706 0.714285714285714 25.1 25 1 thick pulmonary valve 0.0165756628458791 0.0860792512090277 1.98529411764706 0.714285714285714 25.1 25 1 thick mitral valve cusps 0.0165756628458791 0.0860792512090277 1.98529411764706 0.714285714285714 25.1 25 1 increased compact bone volume 0.0165756628458791 0.0860792512090277 1.98529411764706 0.714285714285714 25.1 25 1 abnormal cranial suture morphology 0.000180087330821577 0.00253783321544932 1.96193771626298 0.705882352941177 25.1 25 1 decreased myocardial infarction size 5.83887068962549e-05 0.0010228303408763 1.94558823529412 0.7 25.1 25 1 dilated vasculature 5.83887068962549e-05 0.0010228303408763 1.94558823529412 0.7 25.1 25 1 decreased incidence of induced tumors 0.0049600259714532 0.0341301925421572 1.94558823529412 0.7 25.1 25 1 abnormal respiratory mechanics 0.0049600259714532 0.0341301925421572 1.94558823529412 0.7 25.1 25 1 peritoneal inflammation 0.0049600259714532 0.0341301925421572 1.94558823529412 0.7 25.1 25 1 abnormal hindlimb zeugopod morphology 0.0049600259714532 0.0341301925421572 1.94558823529412 0.7 25.1 25 1 decreased transitional stage T2 B cell number 0.0049600259714532 0.0341301925421572 1.94558823529412 0.7 25.1 25 1 increased circulating fructosamine level 0.0049600259714532 0.0341301925421572 1.94558823529412 0.7 25.1 25 1 abnormal left subclavian artery morphology 0.0049600259714532 0.0341301925421572 1.94558823529412 0.7 25.1 25 1 thick aortic valve 0.0049600259714532 0.0341301925421572 1.94558823529412 0.7 25.1 25 1 fusion of atlas and odontoid process 0.0049600259714532 0.0341301925421572 1.94558823529412 0.7 25.1 25 1 decreased macrophage apoptosis 0.0049600259714532 0.0341301925421572 1.94558823529412 0.7 25.1 25 1 decreased circulating lactate level 0.0049600259714532 0.0341301925421572 1.94558823529412 0.7 25.1 25 1 abnormal hematopoietic stem cell physiology 1.9083281582958e-05 0.000401467909754087 1.93350383631714 0.695652173913043 25.1 25 1 abnormal xiphoid process morphology 6.27591751563627e-06 0.000160941699176755 1.92420814479638 0.692307692307692 25.1 25 1 abnormal ureter morphology 6.27591751563627e-06 0.000160941699176755 1.92420814479638 0.692307692307692 25.1 25 1 absent common myeloid progenitor cells 0.00153725034620741 0.0139813902602959 1.92420814479638 0.692307692307692 25.1 25 1 absent trabeculae carneae 0.00153725034620741 0.0139813902602959 1.92420814479638 0.692307692307692 25.1 25 1 abnormal aorta tunica media morphology 0.00153725034620741 0.0139813902602959 1.92420814479638 0.692307692307692 25.1 25 1 absent hypoglossal nerve 0.00153725034620741 0.0139813902602959 1.92420814479638 0.692307692307692 25.1 25 1 disorganized yolk sac vascular plexus 0.000486711549474297 0.00582064893902554 1.91084558823529 0.6875 25.1 25 1 abnormal artery morphology 2.29170584261191e-07 8.32207048685713e-06 1.90588235294118 0.685714285714286 25.1 25 1 thin dermal layer 0.000156328543969437 0.00225430291666072 1.90170278637771 0.684210526315789 25.1 25 1 intracranial hemorrhage 1.43193577855453e-11 1.45385316292016e-09 1.89926470588235 0.683333333333333 25.1 25 1 hemopericardium 2.56082442244228e-08 1.23690305841265e-06 1.89813486370158 0.682926829268293 25.1 25 1 embryonic lethality before implantation, incomplete penetrance 5.07331437841691e-05 0.000924532565297588 1.89505347593583 0.681818181818182 25.1 25 1 atrioventricular septal defect 3.27063129977193e-10 2.50329087944082e-08 1.88790233074362 0.679245283018868 25.1 25 1 vertebral transformation 6.45164086980706e-09 3.7321992241035e-07 1.85294117647059 0.666666666666667 25.1 25 1 liver degeneration 0.000132365208589012 0.00194827488973472 1.85294117647059 0.666666666666667 25.1 25 1 abnormal radius morphology 0.000409789477102912 0.00505881550517863 1.85294117647059 0.666666666666667 25.1 25 1 abnormal metacarpal bone morphology 0.000409789477102912 0.00505881550517863 1.85294117647059 0.666666666666667 25.1 25 1 abnormal body wall morphology 0.000409789477102912 0.00505881550517863 1.85294117647059 0.666666666666667 25.1 25 1 abnormal thymus involution 0.00409185898587505 0.030025071467151 1.85294117647059 0.666666666666667 25.1 25 1 abnormal embryonic growth/weight/body size 0.00409185898587505 0.030025071467151 1.85294117647059 0.666666666666667 25.1 25 1 abnormal aorta elastic fiber morphology 0.00409185898587505 0.030025071467151 1.85294117647059 0.666666666666667 25.1 25 1 increased osteosarcoma incidence 0.00409185898587505 0.030025071467151 1.85294117647059 0.666666666666667 25.1 25 1 abnormal rostral-caudal body axis extension 0.00409185898587505 0.030025071467151 1.85294117647059 0.666666666666667 25.1 25 1 pale placenta 0.00409185898587505 0.030025071467151 1.85294117647059 0.666666666666667 25.1 25 1 increased fibrosarcoma incidence 0.00409185898587505 0.030025071467151 1.85294117647059 0.666666666666667 25.1 25 1 increased skeletal muscle glycogen level 0.00409185898587505 0.030025071467151 1.85294117647059 0.666666666666667 25.1 25 1 heart hyperplasia 0.013385503567714 0.0742429449115842 1.85294117647059 0.666666666666667 25.1 25 1 abnormal cholinergic neuron morphology 0.013385503567714 0.0742429449115842 1.85294117647059 0.666666666666667 25.1 25 1 abnormal geniculate ganglion morphology 0.013385503567714 0.0742429449115842 1.85294117647059 0.666666666666667 25.1 25 1 increased pheochromocytoma incidence 0.013385503567714 0.0742429449115842 1.85294117647059 0.666666666666667 25.1 25 1 abnormal lens capsule morphology 0.013385503567714 0.0742429449115842 1.85294117647059 0.666666666666667 25.1 25 1 abnormal ovary physiology 0.013385503567714 0.0742429449115842 1.85294117647059 0.666666666666667 25.1 25 1 positive geotaxis 0.013385503567714 0.0742429449115842 1.85294117647059 0.666666666666667 25.1 25 1 iris coloboma 0.013385503567714 0.0742429449115842 1.85294117647059 0.666666666666667 25.1 25 1 decreased effector memory CD4-positive, alpha-beta T cell number 0.013385503567714 0.0742429449115842 1.85294117647059 0.666666666666667 25.1 25 1 abnormal lung lobe morphology 0.013385503567714 0.0742429449115842 1.85294117647059 0.666666666666667 25.1 25 1 adipose tissue inflammation 0.013385503567714 0.0742429449115842 1.85294117647059 0.666666666666667 25.1 25 1 abnormal bronchus morphology 0.00128393964775419 0.0121629876931381 1.85294117647059 0.666666666666667 25.1 25 1 delayed intramembranous bone ossification 0.00128393964775419 0.0121629876931381 1.85294117647059 0.666666666666667 25.1 25 1 abnormal pericyte morphology 0.00128393964775419 0.0121629876931381 1.85294117647059 0.666666666666667 25.1 25 1 liver vascular congestion 0.00128393964775419 0.0121629876931381 1.85294117647059 0.666666666666667 25.1 25 1 ostium primum atrial septal defect 0.00128393964775419 0.0121629876931381 1.85294117647059 0.666666666666667 25.1 25 1 abnormal coronary vessel morphology 0.00128393964775419 0.0121629876931381 1.85294117647059 0.666666666666667 25.1 25 1 abnormal vitelline vasculature morphology 6.46006535557692e-19 2.0086765714997e-16 1.83682864450128 0.660869565217391 25.1 25 1 abnormal embryonic hematopoiesis 3.93771909852449e-06 0.000107638200632744 1.82398897058824 0.65625 25.1 25 1 double outlet right ventricle 3.51530375433269e-17 7.60375485991529e-15 1.81830676195712 0.654205607476635 25.1 25 1 eyelids open at birth 4.66884837888445e-09 2.79849646806628e-07 1.81730769230769 0.653846153846154 25.1 25 1 perimembraneous ventricular septal defect 1.74248916700899e-11 1.66709300112879e-09 1.81265984654731 0.652173913043478 25.1 25 1 pale yolk sac 1.95664240007342e-13 2.63089079469331e-11 1.80829199149539 0.650602409638554 25.1 25 1 increased mammary adenocarcinoma incidence 0.000338216812819633 0.00428149782131724 1.80661764705882 0.65 25.1 25 1 abnormal heart right ventricle morphology 0.000338216812819633 0.00428149782131724 1.80661764705882 0.65 25.1 25 1 absent ductus venosus valve 0.000338216812819633 0.00428149782131724 1.80661764705882 0.65 25.1 25 1 abnormal adipose tissue morphology 0.00104885595033761 0.0104152861335921 1.79844290657439 0.647058823529412 25.1 25 1 abnormal embryonic-extraembryonic boundary morphology 0.00104885595033761 0.0104152861335921 1.79844290657439 0.647058823529412 25.1 25 1 overriding aortic valve 3.45196010508711e-08 1.60500014231854e-06 1.79503676470588 0.645833333333333 25.1 25 1 abnormal myocardial trabeculae morphology 1.02535686683068e-07 4.11383097780858e-06 1.79117647058824 0.644444444444444 25.1 25 1 small placenta 1.02535686683068e-07 4.11383097780858e-06 1.79117647058824 0.644444444444444 25.1 25 1 shortened head 2.9800829179377e-05 0.000577799605585689 1.78676470588235 0.642857142857143 25.1 25 1 abnormal renal tubule epithelium morphology 2.9800829179377e-05 0.000577799605585689 1.78676470588235 0.642857142857143 25.1 25 1 abnormal mitotic spindle morphology 2.9800829179377e-05 0.000577799605585689 1.78676470588235 0.642857142857143 25.1 25 1 absent visceral yolk sac blood islands 0.00329376884254791 0.0252488443631369 1.78676470588235 0.642857142857143 25.1 25 1 amyloid beta deposits 0.00329376884254791 0.0252488443631369 1.78676470588235 0.642857142857143 25.1 25 1 vascular smooth muscle hypoplasia 0.00329376884254791 0.0252488443631369 1.78676470588235 0.642857142857143 25.1 25 1 increased stomach tumor incidence 0.00329376884254791 0.0252488443631369 1.78676470588235 0.642857142857143 25.1 25 1 pulmonary alveolar hemorrhage 0.00329376884254791 0.0252488443631369 1.78676470588235 0.642857142857143 25.1 25 1 decreased compact bone area 0.00329376884254791 0.0252488443631369 1.78676470588235 0.642857142857143 25.1 25 1 multiple persisting craniopharyngeal ducts 0.00329376884254791 0.0252488443631369 1.78676470588235 0.642857142857143 25.1 25 1 abnormal vitelline vein topology 0.00329376884254791 0.0252488443631369 1.78676470588235 0.642857142857143 25.1 25 1 heart right ventricle hypertrophy 2.71390576716591e-06 7.67140976798318e-05 1.77573529411765 0.638888888888889 25.1 25 1 abnormal cell nucleus morphology 8.50371316359956e-08 3.5521150751087e-06 1.77409261576971 0.638297872340426 25.1 25 1 intracerebral hemorrhage 0.000275221321997486 0.00358436145795156 1.76871657754011 0.636363636363636 25.1 25 1 abnormal vascular branching morphogenesis 0.000275221321997486 0.00358436145795156 1.76871657754011 0.636363636363636 25.1 25 1 delayed hepatic development 0.0105312158958546 0.0617839611814581 1.76871657754011 0.636363636363636 25.1 25 1 impaired myelopoiesis 0.0105312158958546 0.0617839611814581 1.76871657754011 0.636363636363636 25.1 25 1 retinal detachment 0.0105312158958546 0.0617839611814581 1.76871657754011 0.636363636363636 25.1 25 1 impaired luteinization 0.0105312158958546 0.0617839611814581 1.76871657754011 0.636363636363636 25.1 25 1 pathological neovascularization 0.0105312158958546 0.0617839611814581 1.76871657754011 0.636363636363636 25.1 25 1 abnormal superovulation 0.0105312158958546 0.0617839611814581 1.76871657754011 0.636363636363636 25.1 25 1 increased number of Howell-Jolly bodies 0.0105312158958546 0.0617839611814581 1.76871657754011 0.636363636363636 25.1 25 1 aberrant origin of the right subclavian artery 0.0105312158958546 0.0617839611814581 1.76871657754011 0.636363636363636 25.1 25 1 aorta dilation 0.0105312158958546 0.0617839611814581 1.76871657754011 0.636363636363636 25.1 25 1 reduced sympathetic cervical ganglion size 0.0105312158958546 0.0617839611814581 1.76871657754011 0.636363636363636 25.1 25 1 embryonic lethality between implantation and somite formation, incomplete penetrance 0.000844293933903157 0.00864272082544898 1.75541795665635 0.631578947368421 25.1 25 1 abnormal dermal layer morphology 6.62729150980789e-06 0.000165934897718231 1.74705882352941 0.628571428571429 25.1 25 1 abnormal truncus arteriosus septation 0.000221645332720387 0.00295626147529202 1.73713235294118 0.625 25.1 25 1 abnormal spongiotrophoblast layer morphology 1.97710814915764e-05 0.000409838043419136 1.73713235294118 0.625 25.1 25 1 intraventricular hemorrhage 0.00261265314488735 0.0211045771769388 1.73713235294118 0.625 25.1 25 1 abnormal olfaction 0.00261265314488735 0.0211045771769388 1.73713235294118 0.625 25.1 25 1 blepharitis 0.00261265314488735 0.0211045771769388 1.73713235294118 0.625 25.1 25 1 dilated respiratory conducting tubes 0.00261265314488735 0.0211045771769388 1.73713235294118 0.625 25.1 25 1 abnormal pupil morphology 0.034620599816901 0.144011274321975 1.73713235294118 0.625 25.1 25 1 absent eyelids 0.034620599816901 0.144011274321975 1.73713235294118 0.625 25.1 25 1 abnormal atrial thrombosis 0.034620599816901 0.144011274321975 1.73713235294118 0.625 25.1 25 1 abnormal hepatobiliary system morphology 0.034620599816901 0.144011274321975 1.73713235294118 0.625 25.1 25 1 abnormal pulmonary circulation 0.034620599816901 0.144011274321975 1.73713235294118 0.625 25.1 25 1 short ureter 0.034620599816901 0.144011274321975 1.73713235294118 0.625 25.1 25 1 decreased corneal stroma thickness 0.034620599816901 0.144011274321975 1.73713235294118 0.625 25.1 25 1 absent tympanic ring 0.034620599816901 0.144011274321975 1.73713235294118 0.625 25.1 25 1 colon polyps 0.034620599816901 0.144011274321975 1.73713235294118 0.625 25.1 25 1 abnormal forelimb zeugopod morphology 0.034620599816901 0.144011274321975 1.73713235294118 0.625 25.1 25 1 increased circulating prolactin level 0.034620599816901 0.144011274321975 1.73713235294118 0.625 25.1 25 1 craniofacial phenotype 0.034620599816901 0.144011274321975 1.73713235294118 0.625 25.1 25 1 stomach epithelial hyperplasia 0.034620599816901 0.144011274321975 1.73713235294118 0.625 25.1 25 1 abnormal epidermal lamellar body morphology 0.034620599816901 0.144011274321975 1.73713235294118 0.625 25.1 25 1 abnormal mitotic spindle assembly checkpoint 0.034620599816901 0.144011274321975 1.73713235294118 0.625 25.1 25 1 skin fibrosis 0.034620599816901 0.144011274321975 1.73713235294118 0.625 25.1 25 1 abnormal olfactory bulb glomerular layer morphology 0.034620599816901 0.144011274321975 1.73713235294118 0.625 25.1 25 1 abnormal circulating serum amyloid protein level 0.034620599816901 0.144011274321975 1.73713235294118 0.625 25.1 25 1 pleural effusion 0.034620599816901 0.144011274321975 1.73713235294118 0.625 25.1 25 1 delayed suture closure 0.034620599816901 0.144011274321975 1.73713235294118 0.625 25.1 25 1 abnormal heart right ventricle pressure 0.034620599816901 0.144011274321975 1.73713235294118 0.625 25.1 25 1 abnormal bronchus epithelium morphology 0.034620599816901 0.144011274321975 1.73713235294118 0.625 25.1 25 1 decreased surfactant secretion 0.034620599816901 0.144011274321975 1.73713235294118 0.625 25.1 25 1 increased circulating ferritin level 0.034620599816901 0.144011274321975 1.73713235294118 0.625 25.1 25 1 increased testis apoptosis 0.034620599816901 0.144011274321975 1.73713235294118 0.625 25.1 25 1 increased brain apoptosis 0.034620599816901 0.144011274321975 1.73713235294118 0.625 25.1 25 1 decreased spleen weight 4.2584749371959e-10 3.20998678978024e-08 1.73209718670077 0.623188405797101 25.1 25 1 abnormal branching of the mammary ductal tree 5.3727829378167e-06 0.000142178697423607 1.72774244833068 0.621621621621622 25.1 25 1 decreased trophoblast giant cell number 5.91050522996272e-05 0.00103174608838823 1.72515212981744 0.620689655172414 25.1 25 1 abnormal placenta morphology 3.34434899005281e-11 3.02511567736595e-09 1.72393894266567 0.620253164556962 25.1 25 1 complete atrioventricular septal defect 0.000672725669694389 0.00712774222170992 1.72058823529412 0.619047619047619 25.1 25 1 embryonic lethality at implantation, complete penetrance 0.000672725669694389 0.00712774222170992 1.72058823529412 0.619047619047619 25.1 25 1 abnormal cell cycle 1.97191658427004e-15 3.27009500224782e-13 1.71598465473146 0.617391304347826 25.1 25 1 small liver 7.90650875508609e-11 6.66692899263615e-09 1.710407239819 0.615384615384615 25.1 25 1 liver hypoplasia 1.11438587802164e-07 4.3313044868419e-06 1.710407239819 0.615384615384615 25.1 25 1 abnormal placenta vasculature 1.11438587802164e-07 4.3313044868419e-06 1.710407239819 0.615384615384615 25.1 25 1 heart inflammation 0.000177108386163198 0.0025102969263872 1.710407239819 0.615384615384615 25.1 25 1 increased foot pad pigmentation 0.00817923280934332 0.0504233992893222 1.710407239819 0.615384615384615 25.1 25 1 excessive scratching 0.00817923280934332 0.0504233992893222 1.710407239819 0.615384615384615 25.1 25 1 increased pituitary adenoma incidence 0.00817923280934332 0.0504233992893222 1.710407239819 0.615384615384615 25.1 25 1 abnormal tail bud morphology 0.00817923280934332 0.0504233992893222 1.710407239819 0.615384615384615 25.1 25 1 abnormal coping response 0.00817923280934332 0.0504233992893222 1.710407239819 0.615384615384615 25.1 25 1 abnormal exocrine pancreas morphology 0.00817923280934332 0.0504233992893222 1.710407239819 0.615384615384615 25.1 25 1 internal hemorrhage 2.38301955206119e-09 1.58073630286725e-07 1.70083406496927 0.611940298507463 25.1 25 1 lowered ear position 0.00205310326542072 0.0174670527425407 1.69852941176471 0.611111111111111 25.1 25 1 abnormal mammary gland morphology 0.00205310326542072 0.0174670527425407 1.69852941176471 0.611111111111111 25.1 25 1 thick dermal layer 0.00205310326542072 0.0174670527425407 1.69852941176471 0.611111111111111 25.1 25 1 abnormal pregnancy 0.00205310326542072 0.0174670527425407 1.69852941176471 0.611111111111111 25.1 25 1 abnormal aerobic respiration 0.00205310326542072 0.0174670527425407 1.69852941176471 0.611111111111111 25.1 25 1 abnormal thoracic vertebrae morphology 2.48950151698121e-08 1.21424216146878e-06 1.69591226321037 0.610169491525424 25.1 25 1 abnormal cell differentiation 3.47692622001129e-06 9.66352399137217e-05 1.69476327116212 0.609756097560976 25.1 25 1 abnormal pulmonary artery morphology 0.000532113056686894 0.00618519265658247 1.69181585677749 0.608695652173913 25.1 25 1 abnormal ulna morphology 0.000532113056686894 0.00618519265658247 1.69181585677749 0.608695652173913 25.1 25 1 abnormal angiogenesis 5.36145362367489e-10 3.92253408496803e-08 1.69018282988871 0.608108108108108 25.1 25 1 kidney cysts 5.36145362367489e-10 3.92253408496803e-08 1.69018282988871 0.608108108108108 25.1 25 1 lymphoid hyperplasia 0.000140672125851327 0.00205836419444221 1.6875 0.607142857142857 25.1 25 1 hemorrhage 5.37473325177628e-28 2.97103310306522e-25 1.67947434292866 0.604255319148936 25.1 25 1 gliosis 1.60696445935009e-08 8.50494487794329e-07 1.67647058823529 0.603174603174603 25.1 25 1 ventricular septal defect 1.0282005263312e-16 2.0461190473991e-14 1.67582179930796 0.602941176470588 25.1 25 1 trabecula carnea hypoplasia 2.21474929596311e-06 6.44349575872308e-05 1.66764705882353 0.6 25.1 25 1 abnormal liver development 2.98996536978326e-05 0.000577799605585689 1.66764705882353 0.6 25.1 25 1 abnormal pericardium morphology 0.00160340961552845 0.0144248875899711 1.66764705882353 0.6 25.1 25 1 abnormal circulating enzyme level 0.00160340961552845 0.0144248875899711 1.66764705882353 0.6 25.1 25 1 abnormal physiological neovascularization 0.00160340961552845 0.0144248875899711 1.66764705882353 0.6 25.1 25 1 increased cranium width 0.0260237199621052 0.115972472200578 1.66764705882353 0.6 25.1 25 1 enlarged testis 0.0260237199621052 0.115972472200578 1.66764705882353 0.6 25.1 25 1 decreased circulating parathyroid hormone level 0.0260237199621052 0.115972472200578 1.66764705882353 0.6 25.1 25 1 delayed dark adaptation 0.0260237199621052 0.115972472200578 1.66764705882353 0.6 25.1 25 1 acrania 0.0260237199621052 0.115972472200578 1.66764705882353 0.6 25.1 25 1 aneurysm 0.0260237199621052 0.115972472200578 1.66764705882353 0.6 25.1 25 1 abnormal plasma membrane morphology 0.0260237199621052 0.115972472200578 1.66764705882353 0.6 25.1 25 1 abnormal deltoid tuberosity morphology 0.0260237199621052 0.115972472200578 1.66764705882353 0.6 25.1 25 1 increased susceptibility to atherosclerosis 0.0260237199621052 0.115972472200578 1.66764705882353 0.6 25.1 25 1 osteosclerosis 0.0260237199621052 0.115972472200578 1.66764705882353 0.6 25.1 25 1 increased platelet aggregation 0.0260237199621052 0.115972472200578 1.66764705882353 0.6 25.1 25 1 protruding tongue 0.0260237199621052 0.115972472200578 1.66764705882353 0.6 25.1 25 1 abnormal hippocampus neuron morphology 0.0260237199621052 0.115972472200578 1.66764705882353 0.6 25.1 25 1 abnormal retinal blood vessel pattern 0.0260237199621052 0.115972472200578 1.66764705882353 0.6 25.1 25 1 abnormal heart and great artery attachment 0.0260237199621052 0.115972472200578 1.66764705882353 0.6 25.1 25 1 abnormal inferior vena cava valve morphology 0.0260237199621052 0.115972472200578 1.66764705882353 0.6 25.1 25 1 thick aortic valve cusps 0.0260237199621052 0.115972472200578 1.66764705882353 0.6 25.1 25 1 abnormal pulmonary interalveolar septum morphology 0.0260237199621052 0.115972472200578 1.66764705882353 0.6 25.1 25 1 abnormal adaptive thermogenesis 0.0260237199621052 0.115972472200578 1.66764705882353 0.6 25.1 25 1 decreased macrophage cytokine production 0.0260237199621052 0.115972472200578 1.66764705882353 0.6 25.1 25 1 abnormal microglial cell physiology 0.000111207188668169 0.00167146756381916 1.66764705882353 0.6 25.1 25 1 abnormal brain vasculature morphology 0.000111207188668169 0.00167146756381916 1.66764705882353 0.6 25.1 25 1 decreased hepatocyte number 0.00630851263473849 0.0406013588070168 1.66764705882353 0.6 25.1 25 1 abnormal pup retrieval 0.00630851263473849 0.0406013588070168 1.66764705882353 0.6 25.1 25 1 arthritis 0.00630851263473849 0.0406013588070168 1.66764705882353 0.6 25.1 25 1 abnormal branching involved in lung morphogenesis 0.00630851263473849 0.0406013588070168 1.66764705882353 0.6 25.1 25 1 heterochrony 0.00630851263473849 0.0406013588070168 1.66764705882353 0.6 25.1 25 1 skin edema 6.42927478461599e-06 0.00016360334431316 1.65441176470588 0.595238095238095 25.1 25 1 abnormal vertebral body morphology 8.75858073412584e-05 0.00138770506854382 1.65027573529412 0.59375 25.1 25 1 failure of primitive streak formation 8.75858073412584e-05 0.00138770506854382 1.65027573529412 0.59375 25.1 25 1 increased fibroblast apoptosis 8.75858073412584e-05 0.00138770506854382 1.65027573529412 0.59375 25.1 25 1 abnormal fetal cardiomyocyte proliferation 0.000328018896924523 0.00421678039328036 1.64705882352941 0.592592592592593 25.1 25 1 abnormal bone trabecula morphology 0.000328018896924523 0.00421678039328036 1.64705882352941 0.592592592592593 25.1 25 1 increased body size 0.0012468986163677 0.0120922429170162 1.64237967914439 0.590909090909091 25.1 25 1 abnormal basement membrane morphology 0.0012468986163677 0.0120922429170162 1.64237967914439 0.590909090909091 25.1 25 1 increased mammary gland tumor incidence 0.0012468986163677 0.0120922429170162 1.64237967914439 0.590909090909091 25.1 25 1 increased vascular permeability 1.86316279367591e-05 0.000394435527597347 1.63914027149321 0.58974358974359 25.1 25 1 increased hepatocyte apoptosis 1.86316279367591e-05 0.000394435527597347 1.63914027149321 0.58974358974359 25.1 25 1 decreased bone marrow cell number 5.17401471280638e-09 3.06437180907283e-07 1.63718775181305 0.589041095890411 25.1 25 1 pericardial edema 1.85682887113873e-08 9.42624860603589e-07 1.63494809688581 0.588235294117647 25.1 25 1 failure of chorioallantoic fusion 1.10250157324225e-06 3.51599059415398e-05 1.63494809688581 0.588235294117647 25.1 25 1 enlarged liver sinusoidal spaces 6.87745808168283e-05 0.00115203211974317 1.63494809688581 0.588235294117647 25.1 25 1 abnormal bone marrow cavity morphology 0.00484664913710125 0.0341301925421572 1.63494809688581 0.588235294117647 25.1 25 1 distended urinary bladder 0.00484664913710125 0.0341301925421572 1.63494809688581 0.588235294117647 25.1 25 1 abnormal vagus nerve morphology 0.00484664913710125 0.0341301925421572 1.63494809688581 0.588235294117647 25.1 25 1 decreased vasoconstriction 0.00484664913710125 0.0341301925421572 1.63494809688581 0.588235294117647 25.1 25 1 abnormal ductus venosus valve morphology 0.00484664913710125 0.0341301925421572 1.63494809688581 0.588235294117647 25.1 25 1 increased mortality induced by gamma-irradiation 0.00025622548004957 0.0033812248361979 1.62931034482759 0.586206896551724 25.1 25 1 blood in lymph vessels 0.00025622548004957 0.0033812248361979 1.62931034482759 0.586206896551724 25.1 25 1 abnormal mammary gland development 1.4651460001792e-05 0.000328337898688808 1.62697274031564 0.585365853658537 25.1 25 1 abnormal axon morphology 2.8140866722258e-12 3.25583283588916e-10 1.62132352941176 0.583333333333333 25.1 25 1 short radius 5.3871512127255e-05 0.000964067528176595 1.62132352941176 0.583333333333333 25.1 25 1 abnormal retinal blood vessel morphology 5.3871512127255e-05 0.000964067528176595 1.62132352941176 0.583333333333333 25.1 25 1 ocular hypertelorism 0.000966767870239997 0.00969691563395964 1.62132352941176 0.583333333333333 25.1 25 1 abnormal vasodilation 0.000966767870239997 0.00969691563395964 1.62132352941176 0.583333333333333 25.1 25 1 blindness 0.000966767870239997 0.00969691563395964 1.62132352941176 0.583333333333333 25.1 25 1 abnormal inner cell mass apoptosis 0.000966767870239997 0.00969691563395964 1.62132352941176 0.583333333333333 25.1 25 1 abnormal supraoccipital bone morphology 0.0195463155698259 0.0923484520036883 1.62132352941176 0.583333333333333 25.1 25 1 amyloidosis 0.0195463155698259 0.0923484520036883 1.62132352941176 0.583333333333333 25.1 25 1 abnormal mating frequency 0.0195463155698259 0.0923484520036883 1.62132352941176 0.583333333333333 25.1 25 1 interstitial pneumonia 0.0195463155698259 0.0923484520036883 1.62132352941176 0.583333333333333 25.1 25 1 abnormal respiratory function 0.0195463155698259 0.0923484520036883 1.62132352941176 0.583333333333333 25.1 25 1 abnormal corticospinal tract morphology 0.0195463155698259 0.0923484520036883 1.62132352941176 0.583333333333333 25.1 25 1 abnormal vascular endothelial cell development 0.0195463155698259 0.0923484520036883 1.62132352941176 0.583333333333333 25.1 25 1 bowed ulna 0.0195463155698259 0.0923484520036883 1.62132352941176 0.583333333333333 25.1 25 1 abnormal palatine bone morphology 0.0195463155698259 0.0923484520036883 1.62132352941176 0.583333333333333 25.1 25 1 reduced cerebellar foliation 0.0195463155698259 0.0923484520036883 1.62132352941176 0.583333333333333 25.1 25 1 decreased prostaglandin level 0.0195463155698259 0.0923484520036883 1.62132352941176 0.583333333333333 25.1 25 1 decreased red blood cell distribution width 0.0195463155698259 0.0923484520036883 1.62132352941176 0.583333333333333 25.1 25 1 persistent right dorsal aorta 0.0195463155698259 0.0923484520036883 1.62132352941176 0.583333333333333 25.1 25 1 pallor 6.33509511172533e-19 2.0086765714997e-16 1.62 0.582857142857143 25.1 25 1 abnormal placenta labyrinth morphology 2.57024467771391e-09 1.66064510021126e-07 1.61839166046165 0.582278481012658 25.1 25 1 lethality throughout fetal growth and development, incomplete penetrance 3.98303495595438e-19 1.41539992184807e-16 1.61485376273414 0.581005586592179 25.1 25 1 abnormal eyelid morphology 0.000199665246083775 0.00275054669071618 1.61385199240987 0.580645161290323 25.1 25 1 abnormal capillary morphology 0.000199665246083775 0.00275054669071618 1.61385199240987 0.580645161290323 25.1 25 1 decreased thymus weight 0.000199665246083775 0.00275054669071618 1.61385199240987 0.580645161290323 25.1 25 1 incomplete embryo turning 5.39181635086493e-07 1.80028767419819e-05 1.60913312693498 0.578947368421053 25.1 25 1 persistence of hyaloid vascular system 4.21131068004614e-05 0.000781763829598117 1.60913312693498 0.578947368421053 25.1 25 1 enlarged adrenal glands 0.00371521609625735 0.0277304515823932 1.60913312693498 0.578947368421053 25.1 25 1 abnormal stationary movement 0.00371521609625735 0.0277304515823932 1.60913312693498 0.578947368421053 25.1 25 1 increased malignant tumor incidence 0.00371521609625735 0.0277304515823932 1.60913312693498 0.578947368421053 25.1 25 1 oliguria 0.00371521609625735 0.0277304515823932 1.60913312693498 0.578947368421053 25.1 25 1 abnormal sternebra morphology 0.00371521609625735 0.0277304515823932 1.60913312693498 0.578947368421053 25.1 25 1 abnormal blastocyst morphology 0.00371521609625735 0.0277304515823932 1.60913312693498 0.578947368421053 25.1 25 1 increased liver cholesterol level 0.00371521609625735 0.0277304515823932 1.60913312693498 0.578947368421053 25.1 25 1 increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 0.00371521609625735 0.0277304515823932 1.60913312693498 0.578947368421053 25.1 25 1 decreased susceptibility to weight gain 0.00371521609625735 0.0277304515823932 1.60913312693498 0.578947368421053 25.1 25 1 ventricular hypoplasia 0.000747978210266244 0.00773636506460409 1.60350678733032 0.576923076923077 25.1 25 1 abnormal Mullerian duct morphology 0.000747978210266244 0.00773636506460409 1.60350678733032 0.576923076923077 25.1 25 1 pulmonary edema 0.000747978210266244 0.00773636506460409 1.60350678733032 0.576923076923077 25.1 25 1 increased thymocyte apoptosis 0.000747978210266244 0.00773636506460409 1.60350678733032 0.576923076923077 25.1 25 1 abnormal heart development 1.37404437042266e-16 2.62918105494336e-14 1.60080044676098 0.575949367088608 25.1 25 1 abnormal aorta morphology 0.000155297200658212 0.00224594061998432 1.60026737967914 0.575757575757576 25.1 25 1 abnormal embryo size 3.08149389178095e-12 3.48418911627505e-10 1.59877667881312 0.575221238938053 25.1 25 1 abnormal tibia morphology 7.04662219083208e-06 0.000172694312312264 1.59668335419274 0.574468085106383 25.1 25 1 abnormal T-helper 1 physiology 7.04662219083208e-06 0.000172694312312264 1.59668335419274 0.574468085106383 25.1 25 1 abnormal apoptosis 1.52496240965454e-06 4.53329705403486e-05 1.59558823529412 0.574074074074074 25.1 25 1 axon degeneration 1.52496240965454e-06 4.53329705403486e-05 1.59558823529412 0.574074074074074 25.1 25 1 abnormal neurocranium morphology 1.60191452222954e-08 8.50494487794329e-07 1.59352941176471 0.573333333333333 25.1 25 1 abnormal blood vessel morphology 4.75845956854274e-15 7.17373828893943e-13 1.59097363083164 0.572413793103448 25.1 25 1 abnormal midbrain development 0.000120607816975489 0.00180187354190108 1.58823529411765 0.571428571428571 25.1 25 1 increased muscle cell glucose uptake 0.00284432154330719 0.0225326427992887 1.58823529411765 0.571428571428571 25.1 25 1 abnormal erythropoiesis 3.0365882806508e-11 2.79759753634032e-09 1.58823529411765 0.571428571428571 25.1 25 1 absent corpus callosum 0.000577814591688783 0.00635979556117632 1.58823529411765 0.571428571428571 25.1 25 1 abnormal blood flow velocity 0.0146931847650705 0.0793687233509509 1.58823529411765 0.571428571428571 25.1 25 1 megacephaly 0.0146931847650705 0.0793687233509509 1.58823529411765 0.571428571428571 25.1 25 1 abnormal kidney blood vessel morphology 0.0146931847650705 0.0793687233509509 1.58823529411765 0.571428571428571 25.1 25 1 abnormal adrenal gland secretion 0.0146931847650705 0.0793687233509509 1.58823529411765 0.571428571428571 25.1 25 1 abnormal endplate potential 0.0146931847650705 0.0793687233509509 1.58823529411765 0.571428571428571 25.1 25 1 abnormal ventral body wall morphology 0.0146931847650705 0.0793687233509509 1.58823529411765 0.571428571428571 25.1 25 1 abnormal maternal decidual layer morphology 0.0146931847650705 0.0793687233509509 1.58823529411765 0.571428571428571 25.1 25 1 decreased CNS synapse formation 0.0146931847650705 0.0793687233509509 1.58823529411765 0.571428571428571 25.1 25 1 increased circulating growth hormone level 0.0146931847650705 0.0793687233509509 1.58823529411765 0.571428571428571 25.1 25 1 abnormal glucose tolerance 0.0146931847650705 0.0793687233509509 1.58823529411765 0.571428571428571 25.1 25 1 decreased tongue size 0.0146931847650705 0.0793687233509509 1.58823529411765 0.571428571428571 25.1 25 1 edema 2.60077198007734e-17 5.88129118222035e-15 1.58361833105335 0.569767441860465 25.1 25 1 abnormal myocardium layer morphology 9.86936585868176e-09 5.39561485131228e-07 1.58320923306031 0.569620253164557 25.1 25 1 increased neuron apoptosis 7.73718970872611e-09 4.37414986374004e-07 1.57843137254902 0.567901234567901 25.1 25 1 malocclusion 9.35552727208801e-05 0.00144996100244978 1.5775039745628 0.567567567567568 25.1 25 1 increased circulating phosphate level 9.35552727208801e-05 0.00144996100244978 1.5775039745628 0.567567567567568 25.1 25 1 abnormal humerus morphology 9.35552727208801e-05 0.00144996100244978 1.5775039745628 0.567567567567568 25.1 25 1 delayed eyelid opening 0.000445864784163707 0.00545006707915097 1.575 0.566666666666667 25.1 25 1 abnormal forelimb morphology 1.55061819290804e-05 0.00033852173508783 1.57097186700767 0.565217391304348 25.1 25 1 fragile skeleton 0.00217611984395275 0.0179837146572507 1.57097186700767 0.565217391304348 25.1 25 1 abnormal blood vessel physiology 0.00217611984395275 0.0179837146572507 1.57097186700767 0.565217391304348 25.1 25 1 abnormal corneal stroma morphology 0.00217611984395275 0.0179837146572507 1.57097186700767 0.565217391304348 25.1 25 1 abnormal chondrocyte physiology 0.00217611984395275 0.0179837146572507 1.57097186700767 0.565217391304348 25.1 25 1 abnormal vertebral artery topology 0.00217611984395275 0.0179837146572507 1.57097186700767 0.565217391304348 25.1 25 1 abnormal cornea morphology 2.1466501643569e-08 1.06795845676756e-06 1.56787330316742 0.564102564102564 25.1 25 1 failure of heart looping 7.25009029770176e-05 0.00118648681681139 1.56787330316742 0.564102564102564 25.1 25 1 abnormal joint morphology 2.60934125538638e-06 7.49189277525599e-05 1.56657754010695 0.563636363636364 25.1 25 1 abnormal skeletal muscle fiber morphology 9.74123928124409e-08 3.97234962493356e-06 1.56586578293289 0.563380281690141 25.1 25 1 abnormal bone marrow cell number 0.0110603319788328 0.0636128920169864 1.56341911764706 0.5625 25.1 25 1 abnormal hair follicle orientation 0.0110603319788328 0.0636128920169864 1.56341911764706 0.5625 25.1 25 1 delayed hair appearance 0.0110603319788328 0.0636128920169864 1.56341911764706 0.5625 25.1 25 1 poor circulation 0.0110603319788328 0.0636128920169864 1.56341911764706 0.5625 25.1 25 1 abnormal pulmonary elastic fiber morphology 0.0110603319788328 0.0636128920169864 1.56341911764706 0.5625 25.1 25 1 increased pancreatic beta cell number 0.0110603319788328 0.0636128920169864 1.56341911764706 0.5625 25.1 25 1 small pancreas 0.0110603319788328 0.0636128920169864 1.56341911764706 0.5625 25.1 25 1 bowed radius 0.0110603319788328 0.0636128920169864 1.56341911764706 0.5625 25.1 25 1 increased cochlear outer hair cell number 0.0110603319788328 0.0636128920169864 1.56341911764706 0.5625 25.1 25 1 increased thymus weight 0.0110603319788328 0.0636128920169864 1.56341911764706 0.5625 25.1 25 1 abnormal level of surface class II molecules 0.0110603319788328 0.0636128920169864 1.56341911764706 0.5625 25.1 25 1 abnormal thoracic cage shape 0.0110603319788328 0.0636128920169864 1.56341911764706 0.5625 25.1 25 1 abnormal pulmonary alveolus wall morphology 0.0110603319788328 0.0636128920169864 1.56341911764706 0.5625 25.1 25 1 decreased fibroblast apoptosis 0.0110603319788328 0.0636128920169864 1.56341911764706 0.5625 25.1 25 1 thick ventricular wall 5.61410615079654e-05 0.000990431847525277 1.55918220946915 0.560975609756098 25.1 25 1 short ulna 5.61410615079654e-05 0.000990431847525277 1.55918220946915 0.560975609756098 25.1 25 1 abnormal interventricular septum morphology 9.35535403343402e-06 0.000219541916586482 1.55647058823529 0.56 25.1 25 1 spontaneous skin ulceration 0.0016643975880445 0.0148128407880526 1.55647058823529 0.56 25.1 25 1 abnormal keratinocyte physiology 0.0016643975880445 0.0148128407880526 1.55647058823529 0.56 25.1 25 1 diaphragmatic hernia 0.0016643975880445 0.0148128407880526 1.55647058823529 0.56 25.1 25 1 overexpanded pulmonary alveoli 0.000264892519123965 0.00348634995407863 1.55320069204152 0.558823529411765 25.1 25 1 decreased embryo size 1.51115813638436e-42 1.87950293212805e-39 1.5525166133399 0.558577405857741 25.1 25 1 abnormal cell adhesion 5.63047453853193e-06 0.000148209581106859 1.54411764705882 0.555555555555556 25.1 25 1 altered response to myocardial infarction 3.36033026907193e-05 0.000635651828465128 1.54411764705882 0.555555555555556 25.1 25 1 abnormal uterus morphology 0.000204028198035782 0.00278093228829594 1.54411764705882 0.555555555555556 25.1 25 1 abnormal atrioventricular cushion morphology 0.00127292735194339 0.0121629876931381 1.54411764705882 0.555555555555556 25.1 25 1 decreased circulating fructosamine level 0.00127292735194339 0.0121629876931381 1.54411764705882 0.555555555555556 25.1 25 1 abnormal heart shape 0.00833858147670192 0.0508387779982745 1.54411764705882 0.555555555555556 25.1 25 1 delayed kidney development 0.00833858147670192 0.0508387779982745 1.54411764705882 0.555555555555556 25.1 25 1 abnormal retinal rod cell morphology 0.00833858147670192 0.0508387779982745 1.54411764705882 0.555555555555556 25.1 25 1 abnormal bile duct morphology 0.00833858147670192 0.0508387779982745 1.54411764705882 0.555555555555556 25.1 25 1 increased circulating renin level 0.00833858147670192 0.0508387779982745 1.54411764705882 0.555555555555556 25.1 25 1 long tibia 0.00833858147670192 0.0508387779982745 1.54411764705882 0.555555555555556 25.1 25 1 abnormal neutrophil morphology 0.00833858147670192 0.0508387779982745 1.54411764705882 0.555555555555556 25.1 25 1 increased adipocyte glucose uptake 0.00833858147670192 0.0508387779982745 1.54411764705882 0.555555555555556 25.1 25 1 distorted hair follicle pattern 0.0611644701283847 0.212792474747352 1.54411764705882 0.555555555555556 25.1 25 1 synostosis 0.0611644701283847 0.212792474747352 1.54411764705882 0.555555555555556 25.1 25 1 abnormal sympathetic neuron morphology 0.0611644701283847 0.212792474747352 1.54411764705882 0.555555555555556 25.1 25 1 abnormal germ cell morphology 0.0611644701283847 0.212792474747352 1.54411764705882 0.555555555555556 25.1 25 1 polycythemia 0.0611644701283847 0.212792474747352 1.54411764705882 0.555555555555556 25.1 25 1 decreased circulating bicarbonate level 0.0611644701283847 0.212792474747352 1.54411764705882 0.555555555555556 25.1 25 1 genetic imprinting 0.0611644701283847 0.212792474747352 1.54411764705882 0.555555555555556 25.1 25 1 premature bone ossification 0.0611644701283847 0.212792474747352 1.54411764705882 0.555555555555556 25.1 25 1 premature neuronal precursor differentiation 0.0611644701283847 0.212792474747352 1.54411764705882 0.555555555555556 25.1 25 1 decreased fear-related response 0.0611644701283847 0.212792474747352 1.54411764705882 0.555555555555556 25.1 25 1 decreased cellular sensitivity to ionizing radiation 0.0611644701283847 0.212792474747352 1.54411764705882 0.555555555555556 25.1 25 1 abnormal stria vascularis vasculature morphology 0.0611644701283847 0.212792474747352 1.54411764705882 0.555555555555556 25.1 25 1 liver hyperplasia 0.0611644701283847 0.212792474747352 1.54411764705882 0.555555555555556 25.1 25 1 abnormal posterior eye segment morphology 0.0611644701283847 0.212792474747352 1.54411764705882 0.555555555555556 25.1 25 1 abnormal optic chiasm morphology 0.0611644701283847 0.212792474747352 1.54411764705882 0.555555555555556 25.1 25 1 abnormal liver vasculature morphology 0.0611644701283847 0.212792474747352 1.54411764705882 0.555555555555556 25.1 25 1 decreased transitional stage T1 B cell number 0.0611644701283847 0.212792474747352 1.54411764705882 0.555555555555556 25.1 25 1 abnormal cerebellar layer morphology 0.0611644701283847 0.212792474747352 1.54411764705882 0.555555555555556 25.1 25 1 abnormal incisor color 0.0611644701283847 0.212792474747352 1.54411764705882 0.555555555555556 25.1 25 1 abnormal heart left ventricle pressure 0.0611644701283847 0.212792474747352 1.54411764705882 0.555555555555556 25.1 25 1 abnormal pulmonary alveolar system morphology 0.0611644701283847 0.212792474747352 1.54411764705882 0.555555555555556 25.1 25 1 decreased airway resistance 0.0611644701283847 0.212792474747352 1.54411764705882 0.555555555555556 25.1 25 1 decreased bone trabecular spacing 0.0611644701283847 0.212792474747352 1.54411764705882 0.555555555555556 25.1 25 1 abnormal infrahyoid muscle connection 0.0611644701283847 0.212792474747352 1.54411764705882 0.555555555555556 25.1 25 1 abnormal neural tube closure 2.18622091817839e-08 1.07687614534035e-06 1.54039688164422 0.55421686746988 25.1 25 1 small seminiferous tubules 1.26939826149026e-07 4.82080637474353e-06 1.53994435612083 0.554054054054054 25.1 25 1 increased cellular sensitivity to gamma-irradiation 2.5979922557388e-05 0.000512897280646847 1.53754693366708 0.553191489361702 25.1 25 1 short sternum 0.00097361657524474 0.00974596068781204 1.53346855983773 0.551724137931034 25.1 25 1 abnormal sternum morphology 4.46763176721319e-07 1.5120046286997e-05 1.5306905370844 0.550724637681159 25.1 25 1 embryonic lethality during organogenesis, complete penetrance 5.02887107141734e-47 1.25093167901506e-43 1.52867647058824 0.55 25.1 25 1 increased urine glucose level 0.00629631290603715 0.0406013588070168 1.52867647058824 0.55 25.1 25 1 anencephaly 0.00629631290603715 0.0406013588070168 1.52867647058824 0.55 25.1 25 1 decreased skin tensile strength 0.00629631290603715 0.0406013588070168 1.52867647058824 0.55 25.1 25 1 kidney atrophy 0.00629631290603715 0.0406013588070168 1.52867647058824 0.55 25.1 25 1 abnormal neuron proliferation 0.00629631290603715 0.0406013588070168 1.52867647058824 0.55 25.1 25 1 increased skin tumor incidence 0.00629631290603715 0.0406013588070168 1.52867647058824 0.55 25.1 25 1 muscular ventricular septal defect 2.62028008622019e-06 7.49189277525599e-05 1.52867647058824 0.55 25.1 25 1 abnormal gluconeogenesis 1.55141619296533e-05 0.00033852173508783 1.52595155709343 0.549019607843137 25.1 25 1 small lung 1.55141619296533e-05 0.00033852173508783 1.52595155709343 0.549019607843137 25.1 25 1 increased tumor incidence 1.992986777785e-11 1.87077532443026e-09 1.5241935483871 0.548387096774194 25.1 25 1 abnormal mitochondrial ATP synthesis coupled electron transport 0.000744821366117912 0.00773636506460409 1.5241935483871 0.548387096774194 25.1 25 1 seminiferous tubule degeneration 2.68856242408432e-07 9.48623975873722e-06 1.52296535052377 0.547945205479452 25.1 25 1 abnormal fertility/fecundity 2.68856242408432e-07 9.48623975873722e-06 1.52296535052377 0.547945205479452 25.1 25 1 spina bifida 9.30944205245573e-05 0.00144996100244978 1.52205882352941 0.547619047619048 25.1 25 1 abnormal vascular development 1.21611228049163e-06 3.78134912215368e-05 1.51604278074866 0.545454545454545 25.1 25 1 omphalocele 7.16526742950517e-05 0.00118037104178107 1.51604278074866 0.545454545454545 25.1 25 1 enlarged pericardium 0.000569931598751854 0.00628693947625382 1.51604278074866 0.545454545454545 25.1 25 1 abnormal ovarian folliculogenesis 0.000569931598751854 0.00628693947625382 1.51604278074866 0.545454545454545 25.1 25 1 dilated heart atrium 0.000569931598751854 0.00628693947625382 1.51604278074866 0.545454545454545 25.1 25 1 single kidney 0.000569931598751854 0.00628693947625382 1.51604278074866 0.545454545454545 25.1 25 1 increased myocardial infarction size 0.00476122905563458 0.0340821792111972 1.51604278074866 0.545454545454545 25.1 25 1 abnormal occipital bone morphology 0.00476122905563458 0.0340821792111972 1.51604278074866 0.545454545454545 25.1 25 1 abnormal thrombopoiesis 0.0446147248416059 0.175584954446011 1.51604278074866 0.545454545454545 25.1 25 1 enlarged cranium 0.0446147248416059 0.175584954446011 1.51604278074866 0.545454545454545 25.1 25 1 abnormal eye distance/ position 0.0446147248416059 0.175584954446011 1.51604278074866 0.545454545454545 25.1 25 1 failure of somite differentiation 0.0446147248416059 0.175584954446011 1.51604278074866 0.545454545454545 25.1 25 1 abnormal fear/anxiety-related behavior 0.0446147248416059 0.175584954446011 1.51604278074866 0.545454545454545 25.1 25 1 cyclopia 0.0446147248416059 0.175584954446011 1.51604278074866 0.545454545454545 25.1 25 1 abnormal dorsal-ventral polarity of the somites 0.0446147248416059 0.175584954446011 1.51604278074866 0.545454545454545 25.1 25 1 abnormal Bruch membrane morphology 0.0446147248416059 0.175584954446011 1.51604278074866 0.545454545454545 25.1 25 1 common atrioventricular valve 0.0446147248416059 0.175584954446011 1.51604278074866 0.545454545454545 25.1 25 1 increased subcutaneous adipose tissue amount 0.0446147248416059 0.175584954446011 1.51604278074866 0.545454545454545 25.1 25 1 decreased core body temperature 0.0446147248416059 0.175584954446011 1.51604278074866 0.545454545454545 25.1 25 1 abnormal phrenic nerve innervation pattern to diaphragm 0.0446147248416059 0.175584954446011 1.51604278074866 0.545454545454545 25.1 25 1 chylous ascites 0.0446147248416059 0.175584954446011 1.51604278074866 0.545454545454545 25.1 25 1 thin hypoglossal nerve 0.0446147248416059 0.175584954446011 1.51604278074866 0.545454545454545 25.1 25 1 abnormal visceral yolk sac morphology 1.25271189949504e-07 4.79403207691373e-06 1.51284437825763 0.544303797468354 25.1 25 1 abnormal allantois morphology 5.51474940736231e-05 0.000979852796486697 1.51054987212276 0.543478260869565 25.1 25 1 abnormal myelin sheath morphology 5.51474940736231e-05 0.000979852796486697 1.51054987212276 0.543478260869565 25.1 25 1 ovary cysts 0.000436230602925279 0.00534543657525434 1.50882352941176 0.542857142857143 25.1 25 1 decreased bone volume 0.000436230602925279 0.00534543657525434 1.50882352941176 0.542857142857143 25.1 25 1 lethality throughout fetal growth and development, complete penetrance 4.38497966815452e-16 8.07973105521064e-14 1.50673374613003 0.542105263157895 25.1 25 1 abnormal body weight 0.00360535399470418 0.0273424331153251 1.50551470588235 0.541666666666667 25.1 25 1 abnormal lung saccule morphology 0.00360535399470418 0.0273424331153251 1.50551470588235 0.541666666666667 25.1 25 1 abnormal lung development 5.82659691902202e-08 2.54274733966092e-06 1.50415224913495 0.541176470588235 25.1 25 1 decreased cell proliferation 1.50331242076875e-15 2.57895837700845e-13 1.50238473767886 0.540540540540541 25.1 25 1 decreased width of hypertrophic chondrocyte zone 0.000333996345465078 0.00426084292526924 1.50238473767886 0.540540540540541 25.1 25 1 abnormal extraembryonic tissue morphology 3.65323418563611e-09 2.27185500919246e-07 1.49870242214533 0.53921568627451 25.1 25 1 kinked neural tube 2.51444016331985e-05 0.00050037359250065 1.49660633484163 0.538461538461538 25.1 25 1 thick skin 0.00273355352878578 0.022005548229303 1.49660633484163 0.538461538461538 25.1 25 1 decreased bone resorption 0.00273355352878578 0.022005548229303 1.49660633484163 0.538461538461538 25.1 25 1 short premaxilla 0.0328079121237222 0.141560592207735 1.49660633484163 0.538461538461538 25.1 25 1 absent teeth 0.0328079121237222 0.141560592207735 1.49660633484163 0.538461538461538 25.1 25 1 absent myocardial trabeculae 0.0328079121237222 0.141560592207735 1.49660633484163 0.538461538461538 25.1 25 1 short hair 0.0328079121237222 0.141560592207735 1.49660633484163 0.538461538461538 25.1 25 1 abnormal pulmonary alveolus epithelial cell morphology 0.0328079121237222 0.141560592207735 1.49660633484163 0.538461538461538 25.1 25 1 abnormal lung interstitium morphology 0.0328079121237222 0.141560592207735 1.49660633484163 0.538461538461538 25.1 25 1 abnormal telomere length 0.0328079121237222 0.141560592207735 1.49660633484163 0.538461538461538 25.1 25 1 axonal dystrophy 0.0328079121237222 0.141560592207735 1.49660633484163 0.538461538461538 25.1 25 1 tracheoesophageal fistula 0.0328079121237222 0.141560592207735 1.49660633484163 0.538461538461538 25.1 25 1 small interparietal bone 0.0328079121237222 0.141560592207735 1.49660633484163 0.538461538461538 25.1 25 1 increased cochlear inner hair cell number 0.0328079121237222 0.141560592207735 1.49660633484163 0.538461538461538 25.1 25 1 abnormal chondrocyte morphology 1.93547330788436e-05 0.000402886180197687 1.49264705882353 0.537037037037037 25.1 25 1 abnormal osteoblast physiology 1.93547330788436e-05 0.000402886180197687 1.49264705882353 0.537037037037037 25.1 25 1 increased bone trabecula number 0.000195976963178637 0.00273872301071269 1.49139167862267 0.536585365853659 25.1 25 1 microcephaly 1.51279107428051e-06 4.53329705403486e-05 1.49040920716113 0.536231884057971 25.1 25 1 hydronephrosis 1.20527670097656e-07 4.64825704446387e-06 1.48897058823529 0.535714285714286 25.1 25 1 short mandible 1.4899203065698e-05 0.000332392534761649 1.48897058823529 0.535714285714286 25.1 25 1 abnormal somite shape 0.00207498053685258 0.0174670527425407 1.48897058823529 0.535714285714286 25.1 25 1 abnormal respiration 0.00207498053685258 0.0174670527425407 1.48897058823529 0.535714285714286 25.1 25 1 failure of blastocyst to hatch from the zona pellucida 0.00207498053685258 0.0174670527425407 1.48897058823529 0.535714285714286 25.1 25 1 increased bone resorption 0.00207498053685258 0.0174670527425407 1.48897058823529 0.535714285714286 25.1 25 1 abnormal brainstem morphology 0.00207498053685258 0.0174670527425407 1.48897058823529 0.535714285714286 25.1 25 1 subcutaneous edema 0.00207498053685258 0.0174670527425407 1.48897058823529 0.535714285714286 25.1 25 1 corneal opacity 1.16766223465155e-06 3.67665798569081e-05 1.48757249378625 0.535211267605634 25.1 25 1 decreased birth body size 7.90504720039466e-10 5.69965359738601e-08 1.48722910216718 0.535087719298246 25.1 25 1 kidney failure 0.000150190861187497 0.00218479396025672 1.48666210670315 0.534883720930233 25.1 25 1 abnormal double-strand DNA break repair 0.000150190861187497 0.00218479396025672 1.48666210670315 0.534883720930233 25.1 25 1 embryonic lethality during organogenesis, incomplete penetrance 2.78323559487295e-18 7.28768267604891e-16 1.4863810741688 0.534782608695652 25.1 25 1 abnormal limb morphology 6.9563050669369e-07 2.26193579790922e-05 1.48235294117647 0.533333333333333 25.1 25 1 increased metastatic potential 0.00157676147933735 0.0142625242903697 1.48235294117647 0.533333333333333 25.1 25 1 abnormal cellular respiration 0.00157676147933735 0.0142625242903697 1.48235294117647 0.533333333333333 25.1 25 1 macrocytosis 0.0242756671997357 0.11120759145367 1.48235294117647 0.533333333333333 25.1 25 1 decreased salivation 0.0242756671997357 0.11120759145367 1.48235294117647 0.533333333333333 25.1 25 1 vagina atresia 0.0242756671997357 0.11120759145367 1.48235294117647 0.533333333333333 25.1 25 1 abnormal respiratory system morphology 0.0242756671997357 0.11120759145367 1.48235294117647 0.533333333333333 25.1 25 1 abnormal ear development 0.0242756671997357 0.11120759145367 1.48235294117647 0.533333333333333 25.1 25 1 abnormal heart morphology 4.40693812410266e-18 1.09622585837054e-15 1.47994652406417 0.532467532467532 25.1 25 1 prenatal lethality, complete penetrance 1.91605396026788e-21 7.332591117179e-19 1.47968683876428 0.532374100719424 25.1 25 1 pericardial effusion 6.79990291279899e-06 0.000168306054682462 1.47936432637571 0.532258064516129 25.1 25 1 scoliosis 0.00119934921522703 0.011722519343329 1.4765625 0.53125 25.1 25 1 neonatal lethality 0.00119934921522703 0.011722519343329 1.4765625 0.53125 25.1 25 1 perinatal lethality, incomplete penetrance 1.49266301224036e-17 3.53618975518847e-15 1.47579385736596 0.530973451327434 25.1 25 1 increased sarcoma incidence 6.77264388113185e-05 0.00113830754421051 1.47478991596639 0.530612244897959 25.1 25 1 abnormal skeleton morphology 1.24966217504226e-09 8.51653331621267e-08 1.47429667519182 0.530434782608696 25.1 25 1 abnormal nervous system development 0.000913100563333223 0.00928972454515906 1.47145328719723 0.529411764705882 25.1 25 1 hydroureter 0.0180507251757808 0.0912204732329184 1.47145328719723 0.529411764705882 25.1 25 1 abnormal urinary bladder morphology 0.0180507251757808 0.0912204732329184 1.47145328719723 0.529411764705882 25.1 25 1 abnormal dorsal-ventral axis patterning 0.0180507251757808 0.0912204732329184 1.47145328719723 0.529411764705882 25.1 25 1 absence seizures 0.0180507251757808 0.0912204732329184 1.47145328719723 0.529411764705882 25.1 25 1 increased regulatory T cell number 0.0180507251757808 0.0912204732329184 1.47145328719723 0.529411764705882 25.1 25 1 increased brain size 0.0180507251757808 0.0912204732329184 1.47145328719723 0.529411764705882 25.1 25 1 coloboma 0.0180507251757808 0.0912204732329184 1.47145328719723 0.529411764705882 25.1 25 1 abnormal tendon morphology 0.0180507251757808 0.0912204732329184 1.47145328719723 0.529411764705882 25.1 25 1 abnormal circulating chemokine level 0.0180507251757808 0.0912204732329184 1.47145328719723 0.529411764705882 25.1 25 1 increased trabecular bone mass 0.0180507251757808 0.0912204732329184 1.47145328719723 0.529411764705882 25.1 25 1 abnormal cell cytoskeleton morphology 0.0180507251757808 0.0912204732329184 1.47145328719723 0.529411764705882 25.1 25 1 abnormal systemic arterial blood pressure 0.000695750937801777 0.00730244918895324 1.46691176470588 0.527777777777778 25.1 25 1 abnormal lysosome morphology 0.000695750937801777 0.00730244918895324 1.46691176470588 0.527777777777778 25.1 25 1 abnormal head morphology 3.06188892102117e-05 0.000585195441463318 1.46550802139037 0.527272727272727 25.1 25 1 decreased circulating total protein level 3.06188892102117e-05 0.000585195441463318 1.46550802139037 0.527272727272727 25.1 25 1 pale liver 1.41989374556805e-06 4.33372477558347e-05 1.46482511923688 0.527027027027027 25.1 25 1 hypoglycemia 6.7659500034185e-08 2.87697446726556e-06 1.46442125237192 0.526881720430108 25.1 25 1 cleft palate 1.60168174897409e-10 1.28522043566873e-08 1.4639649753031 0.526717557251908 25.1 25 1 embryonic lethality between implantation and somite formation, complete penetrance 2.34518159846849e-18 6.48182136243374e-16 1.46344537815126 0.526530612244898 25.1 25 1 abnormal axial skeleton morphology 1.09401380247176e-06 3.51143139825614e-05 1.46284829721362 0.526315789473684 25.1 25 1 abnormal compact bone morphology 0.00053054619855806 0.00618519265658247 1.46284829721362 0.526315789473684 25.1 25 1 impaired branching involved in ureteric bud morphogenesis 0.00053054619855806 0.00618519265658247 1.46284829721362 0.526315789473684 25.1 25 1 decreased total retina thickness 0.00053054619855806 0.00618519265658247 1.46284829721362 0.526315789473684 25.1 25 1 irregular coat pigmentation 0.0134756541216403 0.0742429449115842 1.46284829721362 0.526315789473684 25.1 25 1 small superior vagus ganglion 0.0134756541216403 0.0742429449115842 1.46284829721362 0.526315789473684 25.1 25 1 short vibrissae 0.0134756541216403 0.0742429449115842 1.46284829721362 0.526315789473684 25.1 25 1 maternal imprinting 0.0134756541216403 0.0742429449115842 1.46284829721362 0.526315789473684 25.1 25 1 osteoarthritis 0.0134756541216403 0.0742429449115842 1.46284829721362 0.526315789473684 25.1 25 1 decreased eye pigmentation 0.0134756541216403 0.0742429449115842 1.46284829721362 0.526315789473684 25.1 25 1 eyelids fail to open 0.0134756541216403 0.0742429449115842 1.46284829721362 0.526315789473684 25.1 25 1 decreased liver regeneration 0.0134756541216403 0.0742429449115842 1.46284829721362 0.526315789473684 25.1 25 1 decreased liver glycogen level 0.0134756541216403 0.0742429449115842 1.46284829721362 0.526315789473684 25.1 25 1 abnormal cell morphology 2.53165698043028e-09 1.65723598390008e-07 1.46284829721362 0.526315789473684 25.1 25 1 abnormal craniofacial bone morphology 2.35122342547129e-05 0.000471666796037084 1.46284829721362 0.526315789473684 25.1 25 1 abnormal rib morphology 9.58038422326767e-11 7.8135100837306e-09 1.46176470588235 0.525925925925926 25.1 25 1 increased embryonic tissue cell apoptosis 8.43002630908818e-07 2.72333642128011e-05 1.46097285067873 0.525641025641026 25.1 25 1 perinatal lethality 0.000404856924613072 0.00504802807005021 1.45919117647059 0.525 25.1 25 1 abnormal long bone morphology 1.38744878357487e-05 0.000315185283026711 1.45805207328833 0.524590163934426 25.1 25 1 abnormal scapula morphology 0.0100935034050401 0.060137939449191 1.45588235294118 0.523809523809524 25.1 25 1 trunk curl 0.0100935034050401 0.060137939449191 1.45588235294118 0.523809523809524 25.1 25 1 left pulmonary isomerism 0.0100935034050401 0.060137939449191 1.45588235294118 0.523809523809524 25.1 25 1 abnormal tumor vascularization 0.0100935034050401 0.060137939449191 1.45588235294118 0.523809523809524 25.1 25 1 absent segment of posterior cerebral artery 0.0100935034050401 0.060137939449191 1.45588235294118 0.523809523809524 25.1 25 1 increased bone ossification 0.0100935034050401 0.060137939449191 1.45588235294118 0.523809523809524 25.1 25 1 delayed wound healing 0.00018058149914956 0.00253783321544932 1.45012787723785 0.521739130434783 25.1 25 1 atrial septal defect 0.00018058149914956 0.00253783321544932 1.45012787723785 0.521739130434783 25.1 25 1 abnormal cardiovascular development 0.00758134819565112 0.0473834262228195 1.45012787723785 0.521739130434783 25.1 25 1 abnormal basicranium morphology 0.00758134819565112 0.0473834262228195 1.45012787723785 0.521739130434783 25.1 25 1 abnormal bone mineralization 1.80951227502067e-09 1.21653021192268e-07 1.44713174526009 0.520661157024793 25.1 25 1 abnormal hindlimb morphology 0.000105706584889185 0.00160332396287711 1.44529411764706 0.52 25.1 25 1 increased B cell derived lymphoma incidence 0.000105706584889185 0.00160332396287711 1.44529411764706 0.52 25.1 25 1 ruffled hair 0.00570805676858551 0.0379811232400374 1.44529411764706 0.52 25.1 25 1 abnormal primitive streak morphology 0.00570805676858551 0.0379811232400374 1.44529411764706 0.52 25.1 25 1 decreased placenta weight 0.00570805676858551 0.0379811232400374 1.44529411764706 0.52 25.1 25 1 distended pericardium 8.09327708690929e-05 0.0013115326875366 1.44315610859729 0.519230769230769 25.1 25 1 abnormal hair growth 8.09327708690929e-05 0.0013115326875366 1.44315610859729 0.519230769230769 25.1 25 1 decreased tumor growth/size 6.19918551362241e-05 0.00106716082803708 1.44117647058824 0.518518518518518 25.1 25 1 abnormal long bone epiphyseal plate proliferative zone 6.19918551362241e-05 0.00106716082803708 1.44117647058824 0.518518518518518 25.1 25 1 abnormal heart valve morphology 0.00430653556538529 0.0313231205230875 1.44117647058824 0.518518518518518 25.1 25 1 increased brain weight 0.00430653556538529 0.0313231205230875 1.44117647058824 0.518518518518518 25.1 25 1 abnormal type II pneumocyte morphology 0.00430653556538529 0.0313231205230875 1.44117647058824 0.518518518518518 25.1 25 1 abnormal eye morphology 1.76792143538023e-10 1.39609668905026e-08 1.43969530258146 0.517985611510791 25.1 25 1 embryonic lethality, complete penetrance 5.32332719346095e-22 2.20696273228902e-19 1.43762677484787 0.517241379310345 25.1 25 1 abnormal parietal bone morphology 0.00325501335286096 0.0252488443631369 1.43762677484787 0.517241379310345 25.1 25 1 lordosis 0.00325501335286096 0.0252488443631369 1.43762677484787 0.517241379310345 25.1 25 1 abnormal embryonic erythropoiesis 0.00325501335286096 0.0252488443631369 1.43762677484787 0.517241379310345 25.1 25 1 small spleen 2.71995220987126e-07 9.52941003106305e-06 1.43552036199095 0.516483516483517 25.1 25 1 inner cell mass degeneration 0.00246416426677141 0.0201964039986619 1.43453510436433 0.516129032258065 25.1 25 1 decreased neuronal precursor cell number 0.00246416426677141 0.0201964039986619 1.43453510436433 0.516129032258065 25.1 25 1 preaxial polydactyly 0.00246416426677141 0.0201964039986619 1.43453510436433 0.516129032258065 25.1 25 1 abnormal tooth morphology 1.64371203585115e-05 0.000354002916812098 1.43313419117647 0.515625 25.1 25 1 belly spot 0.00186810543273191 0.0161631730918978 1.43181818181818 0.515151515151515 25.1 25 1 increased cardiomyocyte apoptosis 0.00186810543273191 0.0161631730918978 1.43181818181818 0.515151515151515 25.1 25 1 increased osteoblast cell number 0.00186810543273191 0.0161631730918978 1.43181818181818 0.515151515151515 25.1 25 1 decreased sensitivity to xenobiotic induced morbidity/mortality 0.00186810543273191 0.0161631730918978 1.43181818181818 0.515151515151515 25.1 25 1 decreased bone mineral content 1.38441796368354e-14 2.02572922627223e-12 1.4297935520362 0.514423076923077 25.1 25 1 thick pulmonary interalveolar septum 0.00141802169788282 0.0130884191965993 1.42941176470588 0.514285714285714 25.1 25 1 increased carcinoma incidence 0.00141802169788282 0.0130884191965993 1.42941176470588 0.514285714285714 25.1 25 1 decreased glycogen level 0.00141802169788282 0.0130884191965993 1.42941176470588 0.514285714285714 25.1 25 1 increased red blood cell distribution width 0.00141802169788282 0.0130884191965993 1.42941176470588 0.514285714285714 25.1 25 1 impaired adaptive thermogenesis 0.00141802169788282 0.0130884191965993 1.42941176470588 0.514285714285714 25.1 25 1 decreased bone mineralization 0.00141802169788282 0.0130884191965993 1.42941176470588 0.514285714285714 25.1 25 1 hydrops fetalis 5.71513839818484e-06 0.000149646387005103 1.42830882352941 0.513888888888889 25.1 25 1 increased bone mineral content 2.60670553508565e-08 1.2469576958703e-06 1.42795466810577 0.513761467889908 25.1 25 1 abnormal intestine morphology 4.39140152384304e-06 0.000118734905332169 1.42726550079491 0.513513513513513 25.1 25 1 preweaning lethality, incomplete penetrance 4.64572155779658e-27 2.10113315909436e-24 1.42708183517906 0.513447432762836 25.1 25 1 kyphosis 7.40273177591256e-11 6.34975699744224e-09 1.42676470588235 0.513333333333333 25.1 25 1 abnormal iris morphology 0.000819750462124605 0.00840878051354621 1.42533936651584 0.512820512820513 25.1 25 1 short humerus 0.000624180884119223 0.00673600845660116 1.42360114777618 0.51219512195122 25.1 25 1 palatal shelves fail to meet at midline 0.000624180884119223 0.00673600845660116 1.42360114777618 0.51219512195122 25.1 25 1 lethality at weaning, incomplete penetrance 0.000624180884119223 0.00673600845660116 1.42360114777618 0.51219512195122 25.1 25 1 impaired glucose tolerance 7.9363295439143e-17 1.6451349783739e-14 1.42332779886148 0.512096774193548 25.1 25 1 abnormal vasculogenesis 0.000475674035147354 0.00571613121946397 1.42202462380301 0.511627906976744 25.1 25 1 abnormal blood circulation 0.000475674035147354 0.00571613121946397 1.42202462380301 0.511627906976744 25.1 25 1 delayed endochondral bone ossification 0.000475674035147354 0.00571613121946397 1.42202462380301 0.511627906976744 25.1 25 1 decreased oxygen consumption 0.000475674035147354 0.00571613121946397 1.42202462380301 0.511627906976744 25.1 25 1 thin ventricular wall 5.37521861781431e-07 1.80028767419819e-05 1.42058823529412 0.511111111111111 25.1 25 1 abnormal long bone hypertrophic chondrocyte zone 0.000211462049177502 0.00282802068456471 1.41806722689076 0.510204081632653 25.1 25 1 absent kidney 0.000211462049177502 0.00282802068456471 1.41806722689076 0.510204081632653 25.1 25 1 abnormal liver physiology 1.45398070067606e-07 5.39817461631596e-06 1.4175 0.51 25.1 25 1 abnormal cervical vertebrae morphology 0.000161597070857462 0.00231018801010309 1.41695501730104 0.509803921568627 25.1 25 1 abnormal trophoblast layer morphology 0.000161597070857462 0.00231018801010309 1.41695501730104 0.509803921568627 25.1 25 1 abnormal dendritic spine morphology 0.000161597070857462 0.00231018801010309 1.41695501730104 0.509803921568627 25.1 25 1 short snout 5.11985835498585e-08 2.2540969306243e-06 1.41544117647059 0.509259259259259 25.1 25 1 abnormal platelet physiology 9.45267827631997e-05 0.00145594657661585 1.41497326203209 0.509090909090909 25.1 25 1 abnormal T-helper 2 physiology 9.45267827631997e-05 0.00145594657661585 1.41497326203209 0.509090909090909 25.1 25 1 decreased brain weight 7.23505717856569e-05 0.00118648681681139 1.4140866873065 0.508771929824561 25.1 25 1 abnormal kidney morphology 5.01257139909386e-12 5.42120493706347e-10 1.41352941176471 0.508571428571429 25.1 25 1 increased osteoclast cell number 4.24421547478678e-05 0.00078494319654514 1.41248794599807 0.508196721311475 25.1 25 1 rib fusion 1.91252049470791e-05 0.000401467909754087 1.41044776119403 0.507462686567164 25.1 25 1 thymus hypoplasia 1.03474645191192e-09 7.2505121102279e-08 1.40984654731458 0.507246376811594 25.1 25 1 increased circulating free fatty acid level 1.12602079198281e-05 0.000258154536410805 1.4092792046396 0.507042253521127 25.1 25 1 spleen hyperplasia 6.63739590872925e-06 0.000165934897718231 1.40823529411765 0.506666666666667 25.1 25 1 abnormal somite development 3.91656312748822e-06 0.000107638200632744 1.40729709605361 0.506329113924051 25.1 25 1 abnormal response to infection 3.91656312748822e-06 0.000107638200632744 1.40729709605361 0.506329113924051 25.1 25 1 abnormal brain morphology 8.90437695668252e-11 7.38321255991592e-09 1.39833759590793 0.503105590062112 25.1 25 1 abnormal foregut morphology 0.0115573423965981 0.0658622891444163 1.38970588235294 0.5 25.1 25 1 decreased body height 0.0115573423965981 0.0658622891444163 1.38970588235294 0.5 25.1 25 1 decreased metastatic potential 0.0115573423965981 0.0658622891444163 1.38970588235294 0.5 25.1 25 1 decreased fatty acid level 0.0115573423965981 0.0658622891444163 1.38970588235294 0.5 25.1 25 1 increased body temperature 0.0115573423965981 0.0658622891444163 1.38970588235294 0.5 25.1 25 1 abnormal facial nerve morphology 0.0154257777544456 0.0819906456499647 1.38970588235294 0.5 25.1 25 1 abnormal tail movements 0.0154257777544456 0.0819906456499647 1.38970588235294 0.5 25.1 25 1 abnormal germ layer development 0.0154257777544456 0.0819906456499647 1.38970588235294 0.5 25.1 25 1 testis hypoplasia 0.0154257777544456 0.0819906456499647 1.38970588235294 0.5 25.1 25 1 increased skin papilloma incidence 0.0154257777544456 0.0819906456499647 1.38970588235294 0.5 25.1 25 1 aphakia 0.0154257777544456 0.0819906456499647 1.38970588235294 0.5 25.1 25 1 abnormal tracheal cartilage morphology 0.0154257777544456 0.0819906456499647 1.38970588235294 0.5 25.1 25 1 abnormal retinal layer morphology 0.0154257777544456 0.0819906456499647 1.38970588235294 0.5 25.1 25 1 abnormal circulating lipid level 0.0154257777544456 0.0819906456499647 1.38970588235294 0.5 25.1 25 1 decreased circulating estradiol level 0.0154257777544456 0.0819906456499647 1.38970588235294 0.5 25.1 25 1 increased circulating creatine kinase level 0.0154257777544456 0.0819906456499647 1.38970588235294 0.5 25.1 25 1 abnormal basioccipital bone morphology 0.0206549953372435 0.0962159192909985 1.38970588235294 0.5 25.1 25 1 abnormal fibula morphology 0.0206549953372435 0.0962159192909985 1.38970588235294 0.5 25.1 25 1 spleen atrophy 0.0206549953372435 0.0962159192909985 1.38970588235294 0.5 25.1 25 1 decreased digestive secretion 0.0696831341133859 0.223964242677283 1.38970588235294 0.5 25.1 25 1 abnormal glossopharyngeal nerve morphology 0.0696831341133859 0.223964242677283 1.38970588235294 0.5 25.1 25 1 impaired embryo implantation 0.0696831341133859 0.223964242677283 1.38970588235294 0.5 25.1 25 1 myocarditis 0.0696831341133859 0.223964242677283 1.38970588235294 0.5 25.1 25 1 increased papilloma incidence 0.0696831341133859 0.223964242677283 1.38970588235294 0.5 25.1 25 1 increased growth rate 0.0696831341133859 0.223964242677283 1.38970588235294 0.5 25.1 25 1 abnormal alisphenoid bone morphology 0.0696831341133859 0.223964242677283 1.38970588235294 0.5 25.1 25 1 loss of dopaminergic neurons 0.0696831341133859 0.223964242677283 1.38970588235294 0.5 25.1 25 1 increased fear-related response 0.0696831341133859 0.223964242677283 1.38970588235294 0.5 25.1 25 1 decreased left ventricle systolic pressure 0.0696831341133859 0.223964242677283 1.38970588235294 0.5 25.1 25 1 stria vascularis degeneration 0.0696831341133859 0.223964242677283 1.38970588235294 0.5 25.1 25 1 small parietal bone 0.0696831341133859 0.223964242677283 1.38970588235294 0.5 25.1 25 1 abnormal fatty acid level 0.0696831341133859 0.223964242677283 1.38970588235294 0.5 25.1 25 1 abnormal thymus corticomedullary boundary morphology 0.0696831341133859 0.223964242677283 1.38970588235294 0.5 25.1 25 1 abnormal otic capsule morphology 0.0963052202946643 0.285359422850479 1.38970588235294 0.5 25.1 25 1 abnormal auchene hair morphology 0.0963052202946643 0.285359422850479 1.38970588235294 0.5 25.1 25 1 absent trophoblast giant cells 0.0963052202946643 0.285359422850479 1.38970588235294 0.5 25.1 25 1 abnormal mammary gland physiology 0.0963052202946643 0.285359422850479 1.38970588235294 0.5 25.1 25 1 abnormal airway responsiveness 0.0963052202946643 0.285359422850479 1.38970588235294 0.5 25.1 25 1 ketoaciduria 0.0963052202946643 0.285359422850479 1.38970588235294 0.5 25.1 25 1 impaired basement membrane formation 0.0963052202946643 0.285359422850479 1.38970588235294 0.5 25.1 25 1 abnormal tibialis anterior morphology 0.0963052202946643 0.285359422850479 1.38970588235294 0.5 25.1 25 1 lymphedema 0.0963052202946643 0.285359422850479 1.38970588235294 0.5 25.1 25 1 bifid ureter 0.0963052202946643 0.285359422850479 1.38970588235294 0.5 25.1 25 1 abnormal glial cell physiology 0.0963052202946643 0.285359422850479 1.38970588235294 0.5 25.1 25 1 abnormal pillar cell morphology 0.0963052202946643 0.285359422850479 1.38970588235294 0.5 25.1 25 1 increased defecation amount 0.0963052202946643 0.285359422850479 1.38970588235294 0.5 25.1 25 1 increased heart rate variability 0.0963052202946643 0.285359422850479 1.38970588235294 0.5 25.1 25 1 abnormal placental transport 0.0963052202946643 0.285359422850479 1.38970588235294 0.5 25.1 25 1 abnormal respiratory conducting tube morphology 0.0963052202946643 0.285359422850479 1.38970588235294 0.5 25.1 25 1 abnormal corneal endothelium morphology 0.0963052202946643 0.285359422850479 1.38970588235294 0.5 25.1 25 1 tachypnea 0.0963052202946643 0.285359422850479 1.38970588235294 0.5 25.1 25 1 decreased thyroxine level 0.0963052202946643 0.285359422850479 1.38970588235294 0.5 25.1 25 1 abnormal cerebellar granule cell migration 0.0963052202946643 0.285359422850479 1.38970588235294 0.5 25.1 25 1 aorta stenosis 0.0963052202946643 0.285359422850479 1.38970588235294 0.5 25.1 25 1 thin ventricle myocardium compact layer 0.0963052202946643 0.285359422850479 1.38970588235294 0.5 25.1 25 1 decreased trabecular bone connectivity density 0.0963052202946643 0.285359422850479 1.38970588235294 0.5 25.1 25 1 increased compact bone area 0.0963052202946643 0.285359422850479 1.38970588235294 0.5 25.1 25 1 lethality during fetal growth through weaning, complete penetrance 0.0963052202946643 0.285359422850479 1.38970588235294 0.5 25.1 25 1 prenatal lethality, incomplete penetrance 1.37315716491308e-18 4.01850405614268e-16 1.38970588235294 0.5 25.1 25 1 decreased double-positive T cell number 4.21958962693144e-07 1.44775575130923e-05 1.38970588235294 0.5 25.1 25 1 abnormal heart ventricle morphology 7.60147909066019e-06 0.00018441014311776 1.38970588235294 0.5 25.1 25 1 abnormal kidney development 8.28802713300603e-05 0.00133439919050825 1.38970588235294 0.5 25.1 25 1 absent mesoderm 8.28802713300603e-05 0.00133439919050825 1.38970588235294 0.5 25.1 25 1 increased body length 0.00031721751346582 0.00409910942725313 1.38970588235294 0.5 25.1 25 1 decreased oocyte number 0.00031721751346582 0.00409910942725313 1.38970588235294 0.5 25.1 25 1 failure to gastrulate 0.000544985134814784 0.00625328880547906 1.38970588235294 0.5 25.1 25 1 embryonic lethality between implantation and placentation, complete penetrance 0.000544985134814784 0.00625328880547906 1.38970588235294 0.5 25.1 25 1 abnormal frontal bone morphology 0.00162465981642296 0.0145633920481158 1.38970588235294 0.5 25.1 25 1 abnormal limb bone morphology 0.00214029245796385 0.017895722652723 1.38970588235294 0.5 25.1 25 1 renal hypoplasia 0.00214029245796385 0.017895722652723 1.38970588235294 0.5 25.1 25 1 abnormal trophoblast giant cell morphology 0.00214029245796385 0.017895722652723 1.38970588235294 0.5 25.1 25 1 short maxilla 0.00282311030213059 0.0224719580049595 1.38970588235294 0.5 25.1 25 1 lung hemorrhage 0.00282311030213059 0.0224719580049595 1.38970588235294 0.5 25.1 25 1 thin skin 0.00282311030213059 0.0224719580049595 1.38970588235294 0.5 25.1 25 1 kidney cortex cysts 0.00372897931831579 0.0277304515823932 1.38970588235294 0.5 25.1 25 1 abnormal depression-related behavior 0.00372897931831579 0.0277304515823932 1.38970588235294 0.5 25.1 25 1 increased fatty acid level 0.00372897931831579 0.0277304515823932 1.38970588235294 0.5 25.1 25 1 emphysema 0.00493326522638456 0.0341301925421572 1.38970588235294 0.5 25.1 25 1 myoclonus 0.00653809059391801 0.0417012829547975 1.38970588235294 0.5 25.1 25 1 abnormal ovulation 0.00653809059391801 0.0417012829547975 1.38970588235294 0.5 25.1 25 1 premature aging 0.00653809059391801 0.0417012829547975 1.38970588235294 0.5 25.1 25 1 abnormal hormone level 0.00653809059391801 0.0417012829547975 1.38970588235294 0.5 25.1 25 1 corneal vascularization 0.00653809059391801 0.0417012829547975 1.38970588235294 0.5 25.1 25 1 abnormal nasal bone morphology 0.0086825600083852 0.0528065232783819 1.38970588235294 0.5 25.1 25 1 increased leukemia incidence 0.0086825600083852 0.0528065232783819 1.38970588235294 0.5 25.1 25 1 abnormal megakaryocyte differentiation 0.0277628688748597 0.122014375134653 1.38970588235294 0.5 25.1 25 1 eye inflammation 0.0277628688748597 0.122014375134653 1.38970588235294 0.5 25.1 25 1 abnormal redox activity 0.0277628688748597 0.122014375134653 1.38970588235294 0.5 25.1 25 1 decreased cellular sensitivity to gamma-irradiation 0.0277628688748597 0.122014375134653 1.38970588235294 0.5 25.1 25 1 abnormal anterior eye segment morphology 0.0277628688748597 0.122014375134653 1.38970588235294 0.5 25.1 25 1 abnormal eye anterior chamber morphology 0.0277628688748597 0.122014375134653 1.38970588235294 0.5 25.1 25 1 darkened coat color 0.0277628688748597 0.122014375134653 1.38970588235294 0.5 25.1 25 1 decreased pulmonary respiratory rate 0.0277628688748597 0.122014375134653 1.38970588235294 0.5 25.1 25 1 atrioventricular block 0.0277628688748597 0.122014375134653 1.38970588235294 0.5 25.1 25 1 increased effector memory CD4-positive, alpha-beta T cell number 0.0277628688748597 0.122014375134653 1.38970588235294 0.5 25.1 25 1 abnormal hypoglossal nerve topology 0.0277628688748597 0.122014375134653 1.38970588235294 0.5 25.1 25 1 decreased mast cell number 0.0374910024206385 0.154915063988934 1.38970588235294 0.5 25.1 25 1 bowed tibia 0.0374910024206385 0.154915063988934 1.38970588235294 0.5 25.1 25 1 abnormal amnion morphology 0.0374910024206385 0.154915063988934 1.38970588235294 0.5 25.1 25 1 decreased creatinine clearance 0.0374910024206385 0.154915063988934 1.38970588235294 0.5 25.1 25 1 kidney degeneration 0.0374910024206385 0.154915063988934 1.38970588235294 0.5 25.1 25 1 impaired somite development 0.0374910024206385 0.154915063988934 1.38970588235294 0.5 25.1 25 1 embryonic lethality between somite formation and embryo turning, incomplete penetrance 0.0374910024206385 0.154915063988934 1.38970588235294 0.5 25.1 25 1 midline facial cleft 0.0509226394823741 0.192947548686071 1.38970588235294 0.5 25.1 25 1 increased hemangioma incidence 0.0509226394823741 0.192947548686071 1.38970588235294 0.5 25.1 25 1 absent otoliths 0.0509226394823741 0.192947548686071 1.38970588235294 0.5 25.1 25 1 abnormal decidualization 0.0509226394823741 0.192947548686071 1.38970588235294 0.5 25.1 25 1 abnormal pancreas development 0.0509226394823741 0.192947548686071 1.38970588235294 0.5 25.1 25 1 abnormal positive T cell selection 0.0509226394823741 0.192947548686071 1.38970588235294 0.5 25.1 25 1 premature hair loss 0.0509226394823741 0.192947548686071 1.38970588235294 0.5 25.1 25 1 increased pulmonary respiratory rate 0.0509226394823741 0.192947548686071 1.38970588235294 0.5 25.1 25 1 abnormal renal tubule epithelial cell primary cilium morphology 0.0509226394823741 0.192947548686071 1.38970588235294 0.5 25.1 25 1 testis degeneration 0.0509226394823741 0.192947548686071 1.38970588235294 0.5 25.1 25 1 decreased response to antigen 0.0509226394823741 0.192947548686071 1.38970588235294 0.5 25.1 25 1 perinatal lethality, complete penetrance 2.99997797374795e-13 3.82689497933232e-11 1.38318144159072 0.497652582159624 25.1 25 1 abnormal bone structure 3.99269806526371e-12 4.41414952770822e-10 1.38250533373971 0.49740932642487 25.1 25 1 reduced fertility 4.38494510682145e-09 2.66037828127277e-07 1.37970799830724 0.496402877697842 25.1 25 1 increased heart weight 4.38494510682145e-09 2.66037828127277e-07 1.37970799830724 0.496402877697842 25.1 25 1 decreased leukocyte cell number 5.68668742759115e-09 3.32838470026658e-07 1.37956204379562 0.496350364963504 25.1 25 1 abnormal definitive hematopoiesis 1.77361315689378e-06 5.22113932280862e-05 1.37476280834915 0.494623655913978 25.1 25 1 preweaning lethality, complete penetrance 1.49765354862878e-41 1.49016528088563e-38 1.37468203497615 0.494594594594595 25.1 25 1 insulin resistance 1.81481366076975e-08 9.30793604363868e-07 1.36864973262032 0.492424242424242 25.1 25 1 abnormal maternal nurturing 0.000122013932538634 0.00181742309694522 1.36692381870781 0.491803278688525 25.1 25 1 absent vitelline blood vessels 0.00020836435936625 0.00280750700656617 1.36532507739938 0.491228070175439 25.1 25 1 abnormal facial morphology 0.00020836435936625 0.00280750700656617 1.36532507739938 0.491228070175439 25.1 25 1 postnatal lethality, incomplete penetrance 2.76790207883022e-31 1.72128910527255e-28 1.36523922949461 0.491197183098592 25.1 25 1 abnormal coat/hair pigmentation 2.45563250179292e-07 8.85273311334765e-06 1.36488970588235 0.491071428571429 25.1 25 1 abnormal contextual conditioning behavior 0.000272496233565972 0.00356754937365977 1.3644385026738 0.490909090909091 25.1 25 1 abnormal embryo turning 0.000272496233565972 0.00356754937365977 1.3644385026738 0.490909090909091 25.1 25 1 enlarged kidney 0.000356565784394146 0.00446829918730699 1.36348501664817 0.490566037735849 25.1 25 1 abnormal thrombosis 0.00046685255443539 0.00566485721540504 1.36245674740484 0.490196078431373 25.1 25 1 polydactyly 1.530842020257e-06 4.53329705403486e-05 1.36134453781513 0.489795918367347 25.1 25 1 decreased circulating creatinine level 0.000611648192247959 0.00671732838064811 1.36134453781513 0.489795918367347 25.1 25 1 pulmonary hypoplasia 0.000801916248216775 0.00824283746875714 1.36013767209011 0.48936170212766 25.1 25 1 decreased bone trabecula number 0.000801916248216775 0.00824283746875714 1.36013767209011 0.48936170212766 25.1 25 1 abnormal locomotor behavior 3.36128727312155e-06 9.44768597953656e-05 1.35949488491049 0.489130434782609 25.1 25 1 embryonic growth arrest 2.87533159000213e-13 3.7644143842791e-11 1.35936295915746 0.489082969432314 25.1 25 1 decreased body length 1.41584037857064e-15 2.51564495835319e-13 1.35927436668098 0.489051094890511 25.1 25 1 oxidative stress 4.37034795787927e-06 0.000118734905332169 1.35882352941176 0.488888888888889 25.1 25 1 cardiomyopathy 0.0010521752520225 0.0104274340215378 1.35882352941176 0.488888888888889 25.1 25 1 decreased bone mineral density 3.97867081081054e-15 6.18558977618201e-13 1.35835913312693 0.488721804511278 25.1 25 1 abnormal cardiovascular system physiology 2.63514783167499e-08 1.24855813929362e-06 1.35835913312693 0.488721804511278 25.1 25 1 impaired macrophage phagocytosis 0.0013816839823609 0.0128965812612486 1.35738714090287 0.488372093023256 25.1 25 1 abnormal neural tube morphology 1.00889316308681e-09 7.17034783765266e-08 1.35539215686274 0.487654320987654 25.1 25 1 increased rib number 2.12064996822111e-05 0.000435282296276231 1.35407239819005 0.487179487179487 25.1 25 1 impaired macrophage chemotaxis 0.00238932370300642 0.0196802738782399 1.35407239819005 0.487179487179487 25.1 25 1 increased granulocyte number 3.59719311427116e-05 0.000672783298627782 1.35214626391097 0.486486486486487 25.1 25 1 increased erythroid progenitor cell number 0.00314705088472808 0.0245786156224838 1.35214626391097 0.486486486486487 25.1 25 1 abnormal pancreatic beta cell physiology 0.00314705088472808 0.0245786156224838 1.35214626391097 0.486486486486487 25.1 25 1 abnormal chromosome morphology 0.00314705088472808 0.0245786156224838 1.35214626391097 0.486486486486487 25.1 25 1 increased trabecular bone volume 0.00314705088472808 0.0245786156224838 1.35214626391097 0.486486486486487 25.1 25 1 abnormal seminiferous tubule morphology 8.01469557087075e-09 4.48012477135753e-07 1.35163174858985 0.486301369863014 25.1 25 1 abnormal neuromuscular synapse morphology 4.68702123706576e-05 0.000860440245549894 1.35110294117647 0.486111111111111 25.1 25 1 abnormal forebrain development 4.68702123706576e-05 0.000860440245549894 1.35110294117647 0.486111111111111 25.1 25 1 embryonic lethality between somite formation and embryo turning, complete penetrance 6.10891005300665e-05 0.00105894869385742 1.35 0.485714285714286 25.1 25 1 increased circulating serum albumin level 0.00415013842836461 0.0303631451192852 1.35 0.485714285714286 25.1 25 1 abnormal embryonic epiblast morphology 0.00415013842836461 0.0303631451192852 1.35 0.485714285714286 25.1 25 1 abnormal cranium morphology 3.79938828198454e-08 1.71835970026119e-06 1.34822212467076 0.485074626865672 25.1 25 1 abnormal tail morphology 0.000103879846712927 0.00158528293680003 1.3475935828877 0.484848484848485 25.1 25 1 decreased systemic arterial blood pressure 0.00548039003415946 0.0372952468216905 1.3475935828877 0.484848484848485 25.1 25 1 abnormal locomotor coordination 0.00548039003415946 0.0372952468216905 1.3475935828877 0.484848484848485 25.1 25 1 decreased erythrocyte cell number 3.15433006257711e-09 2.01189641811809e-07 1.34544773323342 0.484076433121019 25.1 25 1 abnormal object recognition memory 0.0072480473760219 0.045760197583387 1.34487666034156 0.483870967741935 25.1 25 1 abnormal postnatal growth/weight/body size 0.0072480473760219 0.045760197583387 1.34487666034156 0.483870967741935 25.1 25 1 abnormal podocyte morphology 0.0072480473760219 0.045760197583387 1.34487666034156 0.483870967741935 25.1 25 1 anemia 7.86272189839126e-12 8.32277477542479e-10 1.3436018957346 0.483412322274882 25.1 25 1 reduced female fertility 8.54309653771052e-13 1.06254763187775e-10 1.34178498985801 0.482758620689655 25.1 25 1 short limbs 1.06508180052339e-05 0.000246454974772272 1.34178498985801 0.482758620689655 25.1 25 1 abnormal embryonic neuroepithelium morphology 0.000301770105408298 0.00391985972429839 1.34178498985801 0.482758620689655 25.1 25 1 focal hair loss 0.00960229601890456 0.0576253591001812 1.34178498985801 0.482758620689655 25.1 25 1 abnormal outer ear morphology 0.00960229601890456 0.0576253591001812 1.34178498985801 0.482758620689655 25.1 25 1 short tail 1.80119994014348e-05 0.00038459097434394 1.33947554925585 0.481927710843373 25.1 25 1 abnormal maxilla morphology 0.000515756701373262 0.0061092609269809 1.33823529411765 0.481481481481481 25.1 25 1 abnormal neuronal precursor proliferation 0.000515756701373262 0.0061092609269809 1.33823529411765 0.481481481481481 25.1 25 1 abnormal trigeminal nerve morphology 0.0127460112768852 0.0718135969450778 1.33823529411765 0.481481481481481 25.1 25 1 abnormal trigeminal ganglion morphology 0.0127460112768852 0.0718135969450778 1.33823529411765 0.481481481481481 25.1 25 1 abnormal eye muscle morphology 0.0127460112768852 0.0718135969450778 1.33823529411765 0.481481481481481 25.1 25 1 decreased bone ossification 0.0127460112768852 0.0718135969450778 1.33823529411765 0.481481481481481 25.1 25 1 decreased heart weight 2.34306628333391e-05 0.000471666796037084 1.33823529411765 0.481481481481481 25.1 25 1 extramedullary hematopoiesis 1.4475859130269e-06 4.39130482762734e-05 1.3372641509434 0.481132075471698 25.1 25 1 abnormal snout morphology 0.000674807354055352 0.00712774222170992 1.3362556561086 0.480769230769231 25.1 25 1 absent corpus luteum 0.000674807354055352 0.00712774222170992 1.3362556561086 0.480769230769231 25.1 25 1 decreased kidney weight 0.000674807354055352 0.00712774222170992 1.3362556561086 0.480769230769231 25.1 25 1 kinked tail 2.43844898511527e-06 7.0530719191561e-05 1.33520761245675 0.480392156862745 25.1 25 1 delayed bone ossification 5.16467712892389e-05 0.000937747033445123 1.33411764705882 0.48 25.1 25 1 embryonic lethality before implantation, complete penetrance 1.98844151460928e-07 7.27389451116263e-06 1.33411764705882 0.48 25.1 25 1 increased cellular sensitivity to ionizing radiation 0.016956682976302 0.0878744768823983 1.33411764705882 0.48 25.1 25 1 decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 0.016956682976302 0.0878744768823983 1.33411764705882 0.48 25.1 25 1 decreased T cell proliferation 1.64070868418253e-08 8.59213231979797e-07 1.33336645468998 0.47972972972973 25.1 25 1 small heart 0.00115729163601412 0.0113560668425448 1.33180147058824 0.479166666666667 25.1 25 1 curly tail 0.00115729163601412 0.0113560668425448 1.33180147058824 0.479166666666667 25.1 25 1 abnormal ovary morphology 8.75850129850074e-05 0.00138770506854382 1.33098591549296 0.47887323943662 25.1 25 1 abnormal cell death 0.00151709952612957 0.0138997608517396 1.32928388746803 0.478260869565217 25.1 25 1 abnormal lymphocyte physiology 0.00151709952612957 0.0138997608517396 1.32928388746803 0.478260869565217 25.1 25 1 abnormal carpal bone morphology 0.0226165048500072 0.104472712747248 1.32928388746803 0.478260869565217 25.1 25 1 abnormal cranial nerve morphology 0.0226165048500072 0.104472712747248 1.32928388746803 0.478260869565217 25.1 25 1 pancreas inflammation 0.0226165048500072 0.104472712747248 1.32928388746803 0.478260869565217 25.1 25 1 abnormal nasal cavity morphology 0.0226165048500072 0.104472712747248 1.32928388746803 0.478260869565217 25.1 25 1 abnormal Wolffian duct morphology 0.0226165048500072 0.104472712747248 1.32928388746803 0.478260869565217 25.1 25 1 abnormal lens development 0.0226165048500072 0.104472712747248 1.32928388746803 0.478260869565217 25.1 25 1 decreased effector memory CD8-positive, alpha-beta T cell number 0.0226165048500072 0.104472712747248 1.32928388746803 0.478260869565217 25.1 25 1 abnormal embryo development 7.73759153144395e-08 3.26224727702828e-06 1.32839532871972 0.477941176470588 25.1 25 1 abnormal enzyme/coenzyme activity 8.29099195737109e-09 4.58307610976902e-07 1.32774447358561 0.477707006369427 25.1 25 1 hyperglycemia 1.51862792491582e-05 0.000335785507842499 1.32653743315508 0.477272727272727 25.1 25 1 small kidney 1.51862792491582e-05 0.000335785507842499 1.32653743315508 0.477272727272727 25.1 25 1 osteoporosis 0.00199026835352845 0.0171011831758273 1.32653743315508 0.477272727272727 25.1 25 1 decreased sensitivity to induced morbidity/mortality 0.00199026835352845 0.0171011831758273 1.32653743315508 0.477272727272727 25.1 25 1 microphthalmia 1.38863400294242e-08 7.50918930938973e-07 1.32612456747405 0.477124183006536 25.1 25 1 abnormal embryonic tissue morphology 3.01019364254309e-08 1.41280314826905e-06 1.32352941176471 0.476190476190476 25.1 25 1 spleen hypoplasia 2.66863820892268e-06 7.58655719393734e-05 1.32352941176471 0.476190476190476 25.1 25 1 abnormal cartilage morphology 0.00261314965648127 0.0211045771769388 1.32352941176471 0.476190476190476 25.1 25 1 abnormal pancreas morphology 0.00261314965648127 0.0211045771769388 1.32352941176471 0.476190476190476 25.1 25 1 abnormal cytotoxic T cell physiology 0.00261314965648127 0.0211045771769388 1.32352941176471 0.476190476190476 25.1 25 1 abnormal eye pigmentation 0.0302563516392466 0.132504708983496 1.32352941176471 0.476190476190476 25.1 25 1 abnormal embryonic/fetal subventricular zone morphology 0.0302563516392466 0.132504708983496 1.32352941176471 0.476190476190476 25.1 25 1 abnormal craniofacial morphology 3.46138042204234e-06 9.66352399137217e-05 1.32224443175328 0.475728155339806 25.1 25 1 abnormal pulmonary alveolus morphology 4.49001368268096e-06 0.000120744962547772 1.32090856144438 0.475247524752475 25.1 25 1 decreased hemoglobin content 6.52603953725539e-08 2.79888333602117e-06 1.32071339173967 0.475177304964539 25.1 25 1 abnormal motor coordination/ balance 5.82487063315249e-06 0.000151721106805935 1.31951871657754 0.474747474747475 25.1 25 1 increased macrophage cell number 0.000561853285638018 0.00625328880547906 1.31656346749226 0.473684210526316 25.1 25 1 increased bone marrow cell number 0.00451720284620266 0.0325696871882004 1.31656346749226 0.473684210526316 25.1 25 1 incomplete somite formation 0.00451720284620266 0.0325696871882004 1.31656346749226 0.473684210526316 25.1 25 1 abnormal triglyceride level 0.0406213621527572 0.166467279003268 1.31656346749226 0.473684210526316 25.1 25 1 unresponsive to tactile stimuli 0.0406213621527572 0.166467279003268 1.31656346749226 0.473684210526316 25.1 25 1 delayed sexual maturation 0.0406213621527572 0.166467279003268 1.31656346749226 0.473684210526316 25.1 25 1 abnormal metatarsal bone morphology 0.0406213621527572 0.166467279003268 1.31656346749226 0.473684210526316 25.1 25 1 increased circulating VLDL cholesterol level 0.0406213621527572 0.166467279003268 1.31656346749226 0.473684210526316 25.1 25 1 decreased circulating magnesium level 0.0406213621527572 0.166467279003268 1.31656346749226 0.473684210526316 25.1 25 1 lethargy 1.27250868013521e-05 0.000290400490076728 1.31499051233397 0.473118279569892 25.1 25 1 abnormal heart left ventricle morphology 0.000124014045113637 0.00183621986440579 1.3125 0.472222222222222 25.1 25 1 anophthalmia 2.14360125804375e-05 0.000435282296276231 1.31163251817581 0.471910112359551 25.1 25 1 decreased rib number 2.14360125804375e-05 0.000435282296276231 1.31163251817581 0.471910112359551 25.1 25 1 abnormal mesoderm development 0.000958951612681438 0.00969671600221577 1.31104328523862 0.471698113207547 25.1 25 1 impaired hematopoiesis 0.00125372173758184 0.0121347580631706 1.30795847750865 0.470588235294118 25.1 25 1 abnormal vision 0.00784241646262953 0.0488310662097396 1.30795847750865 0.470588235294118 25.1 25 1 decreased osteoblast cell number 0.00784241646262953 0.0488310662097396 1.30795847750865 0.470588235294118 25.1 25 1 increased susceptibility to viral infection induced morbidity/mortality 0.00784241646262953 0.0488310662097396 1.30795847750865 0.470588235294118 25.1 25 1 increased incidence of corneal inflammation 0.054771248860512 0.205961423341683 1.30795847750865 0.470588235294118 25.1 25 1 abnormal testis development 0.054771248860512 0.205961423341683 1.30795847750865 0.470588235294118 25.1 25 1 abnormal melanosome morphology 0.054771248860512 0.205961423341683 1.30795847750865 0.470588235294118 25.1 25 1 abnormal tarsal bone morphology 0.054771248860512 0.205961423341683 1.30795847750865 0.470588235294118 25.1 25 1 enhanced behavioral response to cocaine 0.054771248860512 0.205961423341683 1.30795847750865 0.470588235294118 25.1 25 1 increased hepatoma incidence 0.054771248860512 0.205961423341683 1.30795847750865 0.470588235294118 25.1 25 1 delayed heart development 0.054771248860512 0.205961423341683 1.30795847750865 0.470588235294118 25.1 25 1 premature death 2.54638908441608e-39 2.11138094916166e-36 1.30738880918221 0.470383275261324 25.1 25 1 increased T cell derived lymphoma incidence 0.00163997622088417 0.0146742476598899 1.3046218487395 0.469387755102041 25.1 25 1 increased circulating alkaline phosphatase level 1.77763488550933e-08 9.21222245355095e-07 1.30392156862745 0.469135802469136 25.1 25 1 abnormal skeleton development 6.09176385210942e-05 0.00105894869385742 1.30392156862745 0.469135802469136 25.1 25 1 polydipsia 0.0103531074269391 0.0614638537577827 1.30284926470588 0.46875 25.1 25 1 abnormal heart atrium morphology 0.0103531074269391 0.0614638537577827 1.30284926470588 0.46875 25.1 25 1 pancreatic islet hyperplasia 0.0103531074269391 0.0614638537577827 1.30284926470588 0.46875 25.1 25 1 increased insulin sensitivity 1.28153341447671e-07 4.83002177047092e-06 1.30224187577129 0.468531468531469 25.1 25 1 hunched posture 7.91202085328744e-05 0.00129056733590508 1.30174981384959 0.468354430379747 25.1 25 1 neuron degeneration 0.00214646081069282 0.0179171854583839 1.30100125156446 0.468085106382979 25.1 25 1 prenatal lethality 0.000464101471054213 0.00564524405499929 1.30004743833017 0.467741935483871 25.1 25 1 obese 0.000102776625291435 0.00157327295638427 1.29946524064171 0.467532467532468 25.1 25 1 abnormal glucose homeostasis 3.44460454689911e-09 2.16922881276241e-07 1.29807692307692 0.467032967032967 25.1 25 1 decreased insulin secretion 2.9964281053489e-05 0.000577799605585689 1.29705882352941 0.466666666666667 25.1 25 1 abnormal cell migration 0.00281109981734617 0.0224719580049595 1.29705882352941 0.466666666666667 25.1 25 1 decreased osteoclast cell number 0.00281109981734617 0.0224719580049595 1.29705882352941 0.466666666666667 25.1 25 1 abnormal hair cycle 0.0136876979623596 0.0750786078971763 1.29705882352941 0.466666666666667 25.1 25 1 abnormal spleen marginal zone morphology 0.0136876979623596 0.0750786078971763 1.29705882352941 0.466666666666667 25.1 25 1 abnormal optic cup morphology 0.0136876979623596 0.0750786078971763 1.29705882352941 0.466666666666667 25.1 25 1 abnormal fat pad morphology 0.0136876979623596 0.0750786078971763 1.29705882352941 0.466666666666667 25.1 25 1 absent incisors 0.0742387402296826 0.234202747395479 1.29705882352941 0.466666666666667 25.1 25 1 decreased chondrocyte number 0.0742387402296826 0.234202747395479 1.29705882352941 0.466666666666667 25.1 25 1 audiogenic seizures 0.0742387402296826 0.234202747395479 1.29705882352941 0.466666666666667 25.1 25 1 placental labyrinth hypoplasia 0.0742387402296826 0.234202747395479 1.29705882352941 0.466666666666667 25.1 25 1 abnormal cricoid cartilage morphology 0.0742387402296826 0.234202747395479 1.29705882352941 0.466666666666667 25.1 25 1 dilated ureter 0.0742387402296826 0.234202747395479 1.29705882352941 0.466666666666667 25.1 25 1 abnormal glial cell morphology 0.0742387402296826 0.234202747395479 1.29705882352941 0.466666666666667 25.1 25 1 immune system phenotype 0.0742387402296826 0.234202747395479 1.29705882352941 0.466666666666667 25.1 25 1 abnormal energy homeostasis 0.0742387402296826 0.234202747395479 1.29705882352941 0.466666666666667 25.1 25 1 abnormal cerebral aqueduct morphology 0.0742387402296826 0.234202747395479 1.29705882352941 0.466666666666667 25.1 25 1 decreased thymocyte apoptosis 0.0742387402296826 0.234202747395479 1.29705882352941 0.466666666666667 25.1 25 1 herniated liver 0.0742387402296826 0.234202747395479 1.29705882352941 0.466666666666667 25.1 25 1 decreased hematocrit 1.37785842575353e-07 5.15401929934123e-06 1.29452054794521 0.465753424657534 25.1 25 1 postnatal growth retardation 4.19270164225202e-27 2.08586906702038e-24 1.2943339100346 0.465686274509804 25.1 25 1 decreased body weight 7.7569555735871e-54 3.85908539785958e-50 1.29316734771453 0.465266558966074 25.1 25 1 abnormal homeostasis 0.00368398937310766 0.0277304515823932 1.29274965800274 0.465116279069767 25.1 25 1 decreased liver weight 0.000225484154732797 0.00299942157699376 1.29183927091964 0.464788732394366 25.1 25 1 decreased exploration in new environment 6.53397018490182e-05 0.00110943691706097 1.29044117647059 0.464285714285714 25.1 25 1 rib bifurcation 0.0181262092021234 0.0912204732329184 1.29044117647059 0.464285714285714 25.1 25 1 abnormal circulating cholesterol level 0.0181262092021234 0.0912204732329184 1.29044117647059 0.464285714285714 25.1 25 1 straub tail 0.0181262092021234 0.0912204732329184 1.29044117647059 0.464285714285714 25.1 25 1 decreased total body fat amount 3.15619069560297e-15 5.06517700342734e-13 1.28984677703417 0.464071856287425 25.1 25 1 neurodegeneration 0.00134101619139539 0.0125641347498909 1.28676470588235 0.462962962962963 25.1 25 1 decreased compact bone thickness 0.00038102898652038 0.00476286233150476 1.2859964881475 0.462686567164179 25.1 25 1 abnormal brain wave pattern 0.00174993406631883 0.0155462892498861 1.28280542986425 0.461538461538462 25.1 25 1 abnormal heart looping 0.00634109925465661 0.0407583576122954 1.28280542986425 0.461538461538462 25.1 25 1 abnormal kidney cortex morphology 0.0240487883773735 0.11067781885054 1.28280542986425 0.461538461538462 25.1 25 1 abnormal Schwann cell morphology 0.0240487883773735 0.11067781885054 1.28280542986425 0.461538461538462 25.1 25 1 decreased Peyer's patch number 0.0240487883773735 0.11067781885054 1.28280542986425 0.461538461538462 25.1 25 1 abnormal membranous labyrinth morphology 0.101290467247383 0.295901394336895 1.28280542986425 0.461538461538462 25.1 25 1 abnormal renal/urinary system morphology 0.101290467247383 0.295901394336895 1.28280542986425 0.461538461538462 25.1 25 1 pup cannibalization 0.101290467247383 0.295901394336895 1.28280542986425 0.461538461538462 25.1 25 1 dystrophic cardiac calcinosis 0.101290467247383 0.295901394336895 1.28280542986425 0.461538461538462 25.1 25 1 abnormal bile duct development 0.101290467247383 0.295901394336895 1.28280542986425 0.461538461538462 25.1 25 1 abnormal soleus morphology 0.101290467247383 0.295901394336895 1.28280542986425 0.461538461538462 25.1 25 1 anal atresia 0.101290467247383 0.295901394336895 1.28280542986425 0.461538461538462 25.1 25 1 muscle fatigue 0.101290467247383 0.295901394336895 1.28280542986425 0.461538461538462 25.1 25 1 small otic vesicle 0.101290467247383 0.295901394336895 1.28280542986425 0.461538461538462 25.1 25 1 abnormal vertebral arch development 0.101290467247383 0.295901394336895 1.28280542986425 0.461538461538462 25.1 25 1 increased prostaglandin level 0.101290467247383 0.295901394336895 1.28280542986425 0.461538461538462 25.1 25 1 abnormal muscle physiology 5.37308042744166e-05 0.000964067528176595 1.28040317250496 0.460674157303371 25.1 25 1 abnormal circulating protein level 0.00228444121580827 0.0188475871453502 1.27852941176471 0.46 25.1 25 1 abnormal hepatocyte morphology 7.74707937921847e-06 0.00018441014311776 1.27702702702703 0.459459459459459 25.1 25 1 increased insulin secretion 0.00832958682830322 0.0508387779982745 1.27702702702703 0.459459459459459 25.1 25 1 decreased litter size 1.65327347255917e-12 2.00610622584923e-10 1.27595771404647 0.459074733096085 25.1 25 1 cardiac fibrosis 9.01069564545743e-05 0.00142075479157375 1.27525951557093 0.458823529411765 25.1 25 1 abnormal vertebrae morphology 1.00077730452191e-05 0.000232657340654041 1.27495952509444 0.458715596330275 25.1 25 1 abnormal renal glomerulus morphology 1.00077730452191e-05 0.000232657340654041 1.27495952509444 0.458715596330275 25.1 25 1 abnormal intestinal epithelium morphology 0.00298345011234405 0.0235224473992261 1.27389705882353 0.458333333333333 25.1 25 1 oligodactyly 0.00298345011234405 0.0235224473992261 1.27389705882353 0.458333333333333 25.1 25 1 abnormal cardiovascular system morphology 0.00298345011234405 0.0235224473992261 1.27389705882353 0.458333333333333 25.1 25 1 curly vibrissae 0.0319742576951996 0.139414489074161 1.27389705882353 0.458333333333333 25.1 25 1 abnormal cardiac muscle contractility 0.0319742576951996 0.139414489074161 1.27389705882353 0.458333333333333 25.1 25 1 abnormal osteoblast morphology 0.0319742576951996 0.139414489074161 1.27389705882353 0.458333333333333 25.1 25 1 increased hemoglobin content 0.00109045889560807 0.0107426396151488 1.27193419740778 0.457627118644068 25.1 25 1 abnormal hippocampus pyramidal cell morphology 0.0109517032283264 0.0636128920169864 1.27058823529412 0.457142857142857 25.1 25 1 respiratory distress 4.10914517764946e-08 1.8252676123934e-06 1.26921115266916 0.456647398843931 25.1 25 1 decreased circulating alanine transaminase level 0.000524254878807522 0.00616588184885915 1.26708477508651 0.455882352941176 25.1 25 1 decreased mean corpuscular hemoglobin 0.000524254878807522 0.00616588184885915 1.26708477508651 0.455882352941176 25.1 25 1 decreased B cell proliferation 0.000195704615549305 0.00273872301071269 1.26656738644825 0.455696202531646 25.1 25 1 thrombocytopenia 5.92421597192338e-07 1.96486496402126e-05 1.26511156186613 0.455172413793103 25.1 25 1 female infertility 1.68336344966011e-11 1.64210454158021e-09 1.26431888544892 0.454887218045113 25.1 25 1 cataract 5.2060010798698e-06 0.00013850190038691 1.26336898395722 0.454545454545455 25.1 25 1 decreased circulating serum albumin level 3.59704494605984e-05 0.000672783298627782 1.26336898395722 0.454545454545455 25.1 25 1 increased mean corpuscular hemoglobin 3.59704494605984e-05 0.000672783298627782 1.26336898395722 0.454545454545455 25.1 25 1 abnormal learning/memory/conditioning 0.00184698610655781 0.0161631730918978 1.26336898395722 0.454545454545455 25.1 25 1 renal interstitial fibrosis 0.00509542355609033 0.034965147850413 1.26336898395722 0.454545454545455 25.1 25 1 embryonic lethality, incomplete penetrance 0.00509542355609033 0.034965147850413 1.26336898395722 0.454545454545455 25.1 25 1 abnormal tooth development 0.0144137052542554 0.0788002018021104 1.26336898395722 0.454545454545455 25.1 25 1 abnormal skeleton physiology 0.0144137052542554 0.0788002018021104 1.26336898395722 0.454545454545455 25.1 25 1 abnormal QRS complex 0.0144137052542554 0.0788002018021104 1.26336898395722 0.454545454545455 25.1 25 1 abnormal retinal outer plexiform layer morphology 0.0426151632099141 0.173636721514597 1.26336898395722 0.454545454545455 25.1 25 1 cleft upper lip 0.0426151632099141 0.173636721514597 1.26336898395722 0.454545454545455 25.1 25 1 failure of palatal shelf elevation 0.0426151632099141 0.173636721514597 1.26336898395722 0.454545454545455 25.1 25 1 abnormal cerebral cortex pyramidal cell morphology 0.0426151632099141 0.173636721514597 1.26336898395722 0.454545454545455 25.1 25 1 impaired humoral immune response 0.0426151632099141 0.173636721514597 1.26336898395722 0.454545454545455 25.1 25 1 abnormal ear position 0.139380633172213 0.369626146072367 1.26336898395722 0.454545454545455 25.1 25 1 increased mast cell number 0.139380633172213 0.369626146072367 1.26336898395722 0.454545454545455 25.1 25 1 abnormal food preference 0.139380633172213 0.369626146072367 1.26336898395722 0.454545454545455 25.1 25 1 abnormal hemoglobin 0.139380633172213 0.369626146072367 1.26336898395722 0.454545454545455 25.1 25 1 vasculitis 0.139380633172213 0.369626146072367 1.26336898395722 0.454545454545455 25.1 25 1 fatigue 0.139380633172213 0.369626146072367 1.26336898395722 0.454545454545455 25.1 25 1 fused joints 0.139380633172213 0.369626146072367 1.26336898395722 0.454545454545455 25.1 25 1 abnormal frequency of paradoxical sleep 0.139380633172213 0.369626146072367 1.26336898395722 0.454545454545455 25.1 25 1 pharyngeal arch hypoplasia 0.139380633172213 0.369626146072367 1.26336898395722 0.454545454545455 25.1 25 1 increased glycogen level 0.139380633172213 0.369626146072367 1.26336898395722 0.454545454545455 25.1 25 1 increased circulating triiodothyronine level 0.139380633172213 0.369626146072367 1.26336898395722 0.454545454545455 25.1 25 1 palatal shelf hypoplasia 0.139380633172213 0.369626146072367 1.26336898395722 0.454545454545455 25.1 25 1 abnormal palatal shelf elevation 0.139380633172213 0.369626146072367 1.26336898395722 0.454545454545455 25.1 25 1 hypolactation 0.139380633172213 0.369626146072367 1.26336898395722 0.454545454545455 25.1 25 1 neonatal lethality, incomplete penetrance 3.57010621797256e-11 3.17165686328812e-09 1.26142533936652 0.453846153846154 25.1 25 1 abnormal lung morphology 6.71059727007461e-06 0.000166926107093106 1.26124567474048 0.453781512605042 25.1 25 1 decreased body size 2.7311533303124e-31 1.72128910527255e-28 1.26083591331269 0.453634085213033 25.1 25 1 increased oxygen consumption 0.000123069115065428 0.00182766820134479 1.26043091655267 0.453488372093023 25.1 25 1 decreased neutrophil cell number 8.64904490145615e-06 0.000203928902297367 1.25904977375566 0.452991452991453 25.1 25 1 abnormal muscle morphology 0.00666385762552619 0.0424490290486464 1.25735294117647 0.452380952380952 25.1 25 1 abnormal nervous system physiology 1.11460864200743e-05 0.000256721203425323 1.25677749360614 0.452173913043478 25.1 25 1 cachexia 2.93130738596847e-05 0.000576413211272457 1.25608031674208 0.451923076923077 25.1 25 1 increased lung adenoma incidence 0.0189909396216964 0.0923484520036883 1.25521821631879 0.451612903225806 25.1 25 1 abnormal retinal photoreceptor layer morphology 0.0189909396216964 0.0923484520036883 1.25521821631879 0.451612903225806 25.1 25 1 pale kidney 0.0189909396216964 0.0923484520036883 1.25521821631879 0.451612903225806 25.1 25 1 abnormal CD8-positive, alpha beta T cell morphology 0.0189909396216964 0.0923484520036883 1.25521821631879 0.451612903225806 25.1 25 1 impaired balance 3.78021495445113e-05 0.000704365895070951 1.25346020761246 0.450980392156863 25.1 25 1 increased lung adenocarcinoma incidence 0.00313110364435141 0.0245786156224838 1.25346020761246 0.450980392156863 25.1 25 1 abnormal response to novel object 0.00313110364435141 0.0245786156224838 1.25346020761246 0.450980392156863 25.1 25 1 abnormal CD4-positive, alpha-beta T cell physiology 0.000550461310284539 0.00625328880547906 1.25269262634631 0.450704225352113 25.1 25 1 increased grip strength 9.99594276039011e-05 0.00153487084052286 1.25226244343891 0.450549450549451 25.1 25 1 respiratory failure 6.554953709085e-07 2.15966190084092e-05 1.25165562913907 0.450331125827815 25.1 25 1 abnormal eating behavior 0.00148782380686447 0.0136819287230143 1.25073529411765 0.45 25.1 25 1 impaired ovarian folliculogenesis 0.00871960726325213 0.0528380586293293 1.25073529411765 0.45 25.1 25 1 abnormal skin pigmentation 0.00871960726325213 0.0528380586293293 1.25073529411765 0.45 25.1 25 1 abnormal pancreatic beta cell morphology 0.00871960726325213 0.0528380586293293 1.25073529411765 0.45 25.1 25 1 abnormal dopamine level 0.0569574804563593 0.210111049149934 1.25073529411765 0.45 25.1 25 1 abnormal hearing physiology 0.0569574804563593 0.210111049149934 1.25073529411765 0.45 25.1 25 1 abnormal trachea morphology 0.0569574804563593 0.210111049149934 1.25073529411765 0.45 25.1 25 1 abnormal lens epithelium morphology 0.0569574804563593 0.210111049149934 1.25073529411765 0.45 25.1 25 1 abnormal postnatal subventricular zone morphology 0.0569574804563593 0.210111049149934 1.25073529411765 0.45 25.1 25 1 abnormal response to tactile stimuli 0.0569574804563593 0.210111049149934 1.25073529411765 0.45 25.1 25 1 decreased muscle cell glucose uptake 0.0569574804563593 0.210111049149934 1.25073529411765 0.45 25.1 25 1 cardiac hypertrophy 6.28431198936397e-05 0.00107808455679606 1.24789915966387 0.448979591836735 25.1 25 1 abnormal respiratory system physiology 0.00407813254242244 0.030025071467151 1.24789915966387 0.448979591836735 25.1 25 1 infertility 3.07007055722464e-05 0.000585195441463318 1.24683892248488 0.448598130841121 25.1 25 1 enlarged heart 1.17415177366006e-09 8.11306260272058e-08 1.24594320486815 0.448275862068966 25.1 25 1 abnormal spinal nerve morphology 0.0250518886634886 0.114028495975166 1.24594320486815 0.448275862068966 25.1 25 1 aphagia 0.0250518886634886 0.114028495975166 1.24594320486815 0.448275862068966 25.1 25 1 absent long term depression 0.0250518886634886 0.114028495975166 1.24594320486815 0.448275862068966 25.1 25 1 decreased circulating cholesterol level 6.45589908553669e-08 2.79287808265609e-06 1.24541947926712 0.448087431693989 25.1 25 1 abnormal cytokine secretion 6.86079619431119e-07 2.24555664912488e-05 1.24532085561497 0.448051948051948 25.1 25 1 abnormal femur morphology 0.000923081192552768 0.0093720998631633 1.24451273046532 0.447761194029851 25.1 25 1 hyperactivity 1.96111867324636e-14 2.78759011411447e-12 1.24361820199778 0.44743935309973 25.1 25 1 decreased hair follicle number 0.0114158024328608 0.0654304344510164 1.24342105263158 0.447368421052632 25.1 25 1 abnormal reproductive system physiology 0.0114158024328608 0.0654304344510164 1.24342105263158 0.447368421052632 25.1 25 1 abnormal innervation 0.00531281330338275 0.0363565972274129 1.2418648310388 0.446808510638298 25.1 25 1 increased systemic arterial blood pressure 0.00531281330338275 0.0363565972274129 1.2418648310388 0.446808510638298 25.1 25 1 small testis 6.05749414052712e-11 5.28702339458288e-09 1.23865089514066 0.445652173913043 25.1 25 1 abnormal spermatogenesis 8.6393150570483e-08 3.5521150751087e-06 1.23865089514066 0.445652173913043 25.1 25 1 increased sensitivity to induced morbidity/mortality 8.6393150570483e-08 3.5521150751087e-06 1.23865089514066 0.445652173913043 25.1 25 1 ataxia 2.11735718447213e-08 1.06402545381301e-06 1.23835177635411 0.445544554455446 25.1 25 1 abnormal trabecular bone morphology 1.5677349213887e-05 0.000340588700170688 1.2378892733564 0.445378151260504 25.1 25 1 decreased circulating HDL cholesterol level 7.69395485676002e-06 0.00018441014311776 1.23770680147059 0.4453125 25.1 25 1 abnormal neuron morphology 8.43412562400734e-05 0.00135354112836892 1.23529411764706 0.444444444444444 25.1 25 1 abnormal inflammatory response 0.000741755575906801 0.00773636506460409 1.23529411764706 0.444444444444444 25.1 25 1 abnormal digit morphology 0.000741755575906801 0.00773636506460409 1.23529411764706 0.444444444444444 25.1 25 1 decreased platelet aggregation 0.0032553594696071 0.0252488443631369 1.23529411764706 0.444444444444444 25.1 25 1 abnormal ovarian follicle morphology 0.00692288254708564 0.0439863865539605 1.23529411764706 0.444444444444444 25.1 25 1 abnormal metabolism 0.00692288254708564 0.0439863865539605 1.23529411764706 0.444444444444444 25.1 25 1 rectal prolapse 0.0330910100577642 0.141920495721877 1.23529411764706 0.444444444444444 25.1 25 1 thin epidermis 0.0330910100577642 0.141920495721877 1.23529411764706 0.444444444444444 25.1 25 1 abnormal skin appearance 0.0330910100577642 0.141920495721877 1.23529411764706 0.444444444444444 25.1 25 1 thick interventricular septum 0.0330910100577642 0.141920495721877 1.23529411764706 0.444444444444444 25.1 25 1 absent spleen 0.0763779528490337 0.239131727768372 1.23529411764706 0.444444444444444 25.1 25 1 blepharoptosis 0.0763779528490337 0.239131727768372 1.23529411764706 0.444444444444444 25.1 25 1 abnormal thymus cortex morphology 0.0763779528490337 0.239131727768372 1.23529411764706 0.444444444444444 25.1 25 1 absent allantois 0.0763779528490337 0.239131727768372 1.23529411764706 0.444444444444444 25.1 25 1 increased circulating glycerol level 0.0763779528490337 0.239131727768372 1.23529411764706 0.444444444444444 25.1 25 1 absent inner cell mass 0.0763779528490337 0.239131727768372 1.23529411764706 0.444444444444444 25.1 25 1 jerky movement 0.0763779528490337 0.239131727768372 1.23529411764706 0.444444444444444 25.1 25 1 increased gastrointestinal tumor incidence 0.0763779528490337 0.239131727768372 1.23529411764706 0.444444444444444 25.1 25 1 decreased tumor latency 0.0763779528490337 0.239131727768372 1.23529411764706 0.444444444444444 25.1 25 1 primary atelectasis 0.0763779528490337 0.239131727768372 1.23529411764706 0.444444444444444 25.1 25 1 increased effector memory CD8-positive, alpha-beta T cell number 0.0763779528490337 0.239131727768372 1.23529411764706 0.444444444444444 25.1 25 1 increased circulating aspartate transaminase level 0.00154764924724639 0.0140502828559321 1.23529411764706 0.444444444444444 25.1 25 1 abnormal testis morphology 2.58814327813242e-05 0.000512897280646847 1.23260869565217 0.443478260869565 25.1 25 1 decreased IgM level 0.000108529919587272 0.00164114392081057 1.23211036992116 0.443298969072165 25.1 25 1 abnormal nervous system morphology 0.000461404119476037 0.00562618993723844 1.23138495904691 0.443037974683544 25.1 25 1 thick epidermis 0.000958330040103586 0.00969671600221577 1.23088235294118 0.442857142857143 25.1 25 1 abnormal organ of Corti morphology 0.00902291999202423 0.0545431676310092 1.2281121751026 0.441860465116279 25.1 25 1 lung inflammation 6.45956975122535e-06 0.00016360334431316 1.22621107266436 0.441176470588235 25.1 25 1 abnormal retinal photoreceptor morphology 0.0196015648265916 0.0925216176587221 1.22621107266436 0.441176470588235 25.1 25 1 syndactyly 0.00259400780283692 0.0211045771769388 1.22482552342971 0.440677966101695 25.1 25 1 decreased heart rate 0.00011231093087797 0.00168297253348765 1.22294117647059 0.44 25.1 25 1 short stride length 0.00548746144190501 0.0372952468216905 1.22294117647059 0.44 25.1 25 1 decreased circulating alkaline phosphatase level 0.00548746144190501 0.0372952468216905 1.22294117647059 0.44 25.1 25 1 abnormal axon extension 0.00548746144190501 0.0372952468216905 1.22294117647059 0.44 25.1 25 1 abnormal egg cylinder morphology 0.0437737806886191 0.175584954446011 1.22294117647059 0.44 25.1 25 1 decreased acute inflammation 0.0437737806886191 0.175584954446011 1.22294117647059 0.44 25.1 25 1 abnormal vertebrae development 0.0437737806886191 0.175584954446011 1.22294117647059 0.44 25.1 25 1 abnormal energy expenditure 0.0437737806886191 0.175584954446011 1.22294117647059 0.44 25.1 25 1 abnormal preimplantation embryo development 0.0437737806886191 0.175584954446011 1.22294117647059 0.44 25.1 25 1 increased liver glycogen level 0.0437737806886191 0.175584954446011 1.22294117647059 0.44 25.1 25 1 abnormal dendritic cell physiology 7.03340857555657e-05 0.00116249859346824 1.22086311159978 0.439252336448598 25.1 25 1 Leydig cell hyperplasia 0.0117625563849231 0.0669550549370625 1.22022955523673 0.439024390243902 25.1 25 1 increased hepatocellular carcinoma incidence 0.00335774764088567 0.025660206625816 1.21904024767802 0.43859649122807 25.1 25 1 abnormal circulating amino acid level 0.00335774764088567 0.025660206625816 1.21904024767802 0.43859649122807 25.1 25 1 astrocytosis 0.000988930902150888 0.0098595816396807 1.21837228041902 0.438356164383562 25.1 25 1 decreased percent body fat/body weight 0.000988930902150888 0.0098595816396807 1.21837228041902 0.438356164383562 25.1 25 1 abnormal retina morphology 3.99831025062544e-08 1.79203545016771e-06 1.21764705882353 0.438095238095238 25.1 25 1 abnormal humoral immune response 9.02429174145334e-05 0.00142075479157375 1.21764705882353 0.438095238095238 25.1 25 1 abnormal phalanx morphology 0.00712454022974619 0.0451523409464807 1.21599264705882 0.4375 25.1 25 1 decreased lymphocyte cell number 1.73898315652545e-05 0.000372906948435953 1.21599264705882 0.4375 25.1 25 1 decreased caudal vertebrae number 0.00206456340740857 0.0174670527425407 1.21599264705882 0.4375 25.1 25 1 abnormal auditory brainstem response waveform shape 0.0257092535509522 0.115972472200578 1.21599264705882 0.4375 25.1 25 1 absent mandible 0.102820314081161 0.297228973012073 1.21599264705882 0.4375 25.1 25 1 abnormal mouth morphology 0.102820314081161 0.297228973012073 1.21599264705882 0.4375 25.1 25 1 reduced male mating frequency 0.102820314081161 0.297228973012073 1.21599264705882 0.4375 25.1 25 1 sepsis 0.102820314081161 0.297228973012073 1.21599264705882 0.4375 25.1 25 1 decreased circulating growth hormone level 0.102820314081161 0.297228973012073 1.21599264705882 0.4375 25.1 25 1 decreased circulating triiodothyronine level 0.102820314081161 0.297228973012073 1.21599264705882 0.4375 25.1 25 1 decreased liver cholesterol level 0.102820314081161 0.297228973012073 1.21599264705882 0.4375 25.1 25 1 decreased adipocyte glucose uptake 0.102820314081161 0.297228973012073 1.21599264705882 0.4375 25.1 25 1 increased circulating calcium level 0.00434571304100008 0.0315159218352411 1.21283422459893 0.436363636363636 25.1 25 1 increased urine protein level 0.000789247288255288 0.00814627647109971 1.21153846153846 0.435897435897436 25.1 25 1 small lens 0.015337163979655 0.0819906456499647 1.21153846153846 0.435897435897436 25.1 25 1 decreased trabecular bone volume 0.015337163979655 0.0819906456499647 1.21153846153846 0.435897435897436 25.1 25 1 abnormal circulating insulin level 0.0579987465636884 0.210111049149934 1.20843989769821 0.434782608695652 25.1 25 1 abnormal postnatal growth 0.0579987465636884 0.210111049149934 1.20843989769821 0.434782608695652 25.1 25 1 conjunctivitis 0.0579987465636884 0.210111049149934 1.20843989769821 0.434782608695652 25.1 25 1 abnormal sacral vertebrae morphology 0.0579987465636884 0.210111049149934 1.20843989769821 0.434782608695652 25.1 25 1 abnormal B cell morphology 0.0579987465636884 0.210111049149934 1.20843989769821 0.434782608695652 25.1 25 1 abnormal placenta development 0.00562336055212338 0.0379811232400374 1.20615982241953 0.433962264150943 25.1 25 1 increased erythrocyte cell number 0.00343991321152174 0.026207608311364 1.20441176470588 0.433333333333333 25.1 25 1 abnormal incisor morphology 0.00343991321152174 0.026207608311364 1.20441176470588 0.433333333333333 25.1 25 1 disorganized myocardium 0.0337421521408227 0.144011274321975 1.20441176470588 0.433333333333333 25.1 25 1 enhanced paired-pulse facilitation 0.0337421521408227 0.144011274321975 1.20441176470588 0.433333333333333 25.1 25 1 increased body weight 3.50555461247579e-08 1.61482724046917e-06 1.20358455882353 0.433035714285714 25.1 25 1 decreased white adipose tissue amount 0.00211457694571373 0.0177703045691314 1.20302897278314 0.432835820895522 25.1 25 1 decreased cardiac muscle contractility 0.000152150841949295 0.00220685259095551 1.20263009049774 0.432692307692308 25.1 25 1 impaired skeletal muscle contractility 0.0200017506889775 0.0937876622786646 1.20190779014308 0.432432432432432 25.1 25 1 abnormal hair follicle development 0.0200017506889775 0.0937876622786646 1.20190779014308 0.432432432432432 25.1 25 1 skin inflammation 0.0200017506889775 0.0937876622786646 1.20190779014308 0.432432432432432 25.1 25 1 abnormal respiratory electron transport chain 0.0200017506889775 0.0937876622786646 1.20190779014308 0.432432432432432 25.1 25 1 cyanosis 3.56793810464083e-07 1.24129315178938e-05 1.20151654411765 0.432291666666667 25.1 25 1 short femur 0.000501711683081675 0.00598564897681375 1.20020053475936 0.431818181818182 25.1 25 1 abnormal astrocyte morphology 0.012007817283334 0.0682730182680991 1.20020053475936 0.431818181818182 25.1 25 1 reduced male fertility 3.59080193435108e-08 1.63892106636666e-06 1.19992225965276 0.431718061674009 25.1 25 1 impaired coordination 1.49917213995231e-11 1.49167627925254e-09 1.19691431485889 0.430635838150289 25.1 25 1 increased circulating creatinine level 0.000643025092837173 0.00687967706852675 1.19579343365253 0.430232558139535 25.1 25 1 abnormal liver morphology 1.16716078925688e-06 3.67665798569081e-05 1.19561288202432 0.430167597765363 25.1 25 1 increased monocyte cell number 0.000249044458068996 0.00330398981038201 1.19514705882353 0.43 25.1 25 1 hypoactivity 2.45620499015559e-12 2.90943329191049e-10 1.19433608987362 0.429708222811671 25.1 25 1 limb grasping 1.19104581958854e-06 3.72669997009622e-05 1.19117647058824 0.428571428571429 25.1 25 1 weight loss 1.88927796223036e-06 5.52891638946826e-05 1.19117647058824 0.428571428571429 25.1 25 1 decreased T cell number 4.76134186569753e-06 0.000127353095601318 1.19117647058824 0.428571428571429 25.1 25 1 abnormal B cell differentiation 0.000511567988331088 0.00608863813862958 1.19117647058824 0.428571428571429 25.1 25 1 domed cranium 0.00215452841747367 0.0179544034789473 1.19117647058824 0.428571428571429 25.1 25 1 decreased circulating thyroxine level 0.0260889610252906 0.115989795443093 1.19117647058824 0.428571428571429 25.1 25 1 small superior cervical ganglion 0.0443146106994948 0.175584954446011 1.19117647058824 0.428571428571429 25.1 25 1 abnormal spleen germinal center morphology 0.0443146106994948 0.175584954446011 1.19117647058824 0.428571428571429 25.1 25 1 hypoxia 0.0443146106994948 0.175584954446011 1.19117647058824 0.428571428571429 25.1 25 1 small ears 0.0769833270691941 0.240120408883537 1.19117647058824 0.428571428571429 25.1 25 1 increased vasoconstriction 0.0769833270691941 0.240120408883537 1.19117647058824 0.428571428571429 25.1 25 1 translucent skin 0.13906633807114 0.369626146072367 1.19117647058824 0.428571428571429 25.1 25 1 abnormal placing response 0.13906633807114 0.369626146072367 1.19117647058824 0.428571428571429 25.1 25 1 extended life span 0.13906633807114 0.369626146072367 1.19117647058824 0.428571428571429 25.1 25 1 increased lactate dehydrogenase level 0.13906633807114 0.369626146072367 1.19117647058824 0.428571428571429 25.1 25 1 abnormal prepulse inhibition 0.13906633807114 0.369626146072367 1.19117647058824 0.428571428571429 25.1 25 1 intestinal obstruction 0.13906633807114 0.369626146072367 1.19117647058824 0.428571428571429 25.1 25 1 absent olfactory bulb 0.13906633807114 0.369626146072367 1.19117647058824 0.428571428571429 25.1 25 1 abnormal imprinting 0.13906633807114 0.369626146072367 1.19117647058824 0.428571428571429 25.1 25 1 skeletal muscle necrosis 0.13906633807114 0.369626146072367 1.19117647058824 0.428571428571429 25.1 25 1 enlarged stomach 0.13906633807114 0.369626146072367 1.19117647058824 0.428571428571429 25.1 25 1 split sternum 0.13906633807114 0.369626146072367 1.19117647058824 0.428571428571429 25.1 25 1 abnormal squamosal bone morphology 0.13906633807114 0.369626146072367 1.19117647058824 0.428571428571429 25.1 25 1 increased lung compliance 0.13906633807114 0.369626146072367 1.19117647058824 0.428571428571429 25.1 25 1 retinal degeneration 0.000406917874937664 0.00505881550517863 1.18704044117647 0.427083333333333 25.1 25 1 sparse hair 0.00105481773015113 0.0104328393787314 1.18633428981349 0.426829268292683 25.1 25 1 increased double-negative T cell number 0.00450678004112452 0.0325696871882004 1.18466730954677 0.426229508196721 25.1 25 1 abnormal mandible morphology 0.0073802645810871 0.0464769826467194 1.18382352941176 0.425925925925926 25.1 25 1 abnormal small intestine morphology 0.0073802645810871 0.0464769826467194 1.18382352941176 0.425925925925926 25.1 25 1 cleft secondary palate 0.00051975713671383 0.00614202317138077 1.18272841051314 0.425531914893617 25.1 25 1 neonatal lethality, complete penetrance 5.62787098406782e-14 7.77740504048261e-12 1.18246904024768 0.425438596491228 25.1 25 1 abnormal epidermis stratum basale morphology 0.034032289137992 0.144011274321975 1.17914438502674 0.424242424242424 25.1 25 1 myeloid hyperplasia 0.034032289137992 0.144011274321975 1.17914438502674 0.424242424242424 25.1 25 1 increased percent body fat/body weight 0.00951063131403843 0.0573519888331408 1.17590497737557 0.423076923076923 25.1 25 1 small seminal vesicle 0.0582387750501992 0.210111049149934 1.17590497737557 0.423076923076923 25.1 25 1 increased susceptibility to otitis media 0.0582387750501992 0.210111049149934 1.17590497737557 0.423076923076923 25.1 25 1 abnormal nerve conduction 0.0582387750501992 0.210111049149934 1.17590497737557 0.423076923076923 25.1 25 1 decreased circulating glucose level 6.62111059045054e-09 3.78620979166568e-07 1.17552182163188 0.422939068100358 25.1 25 1 abnormal osteoclast physiology 0.00455359704761429 0.0327372042079207 1.17256433823529 0.421875 25.1 25 1 decreased eosinophil cell number 0.00455359704761429 0.0327372042079207 1.17256433823529 0.421875 25.1 25 1 postnatal lethality 8.03719380331528e-06 0.000190404948435683 1.17204110559887 0.421686746987952 25.1 25 1 increased inflammatory response 0.000670684633652128 0.00712774222170992 1.1702786377709 0.421052631578947 25.1 25 1 seizures 0.000206997432041198 0.00280602785941405 1.1702786377709 0.421052631578947 25.1 25 1 abnormal blood homeostasis 0.000206997432041198 0.00280602785941405 1.1702786377709 0.421052631578947 25.1 25 1 decreased susceptibility to induced arthritis 0.00744564433297032 0.046770303732989 1.1702786377709 0.421052631578947 25.1 25 1 kyphoscoliosis 0.102382746082689 0.297228973012073 1.1702786377709 0.421052631578947 25.1 25 1 flaky skin 0.102382746082689 0.297228973012073 1.1702786377709 0.421052631578947 25.1 25 1 abnormal neurotransmitter level 0.102382746082689 0.297228973012073 1.1702786377709 0.421052631578947 25.1 25 1 decreased germ cell number 0.102382746082689 0.297228973012073 1.1702786377709 0.421052631578947 25.1 25 1 abnormal neural crest cell migration 0.102382746082689 0.297228973012073 1.1702786377709 0.421052631578947 25.1 25 1 abnormal digestive system development 0.102382746082689 0.297228973012073 1.1702786377709 0.421052631578947 25.1 25 1 abnormal optic vesicle formation 0.102382746082689 0.297228973012073 1.1702786377709 0.421052631578947 25.1 25 1 abnormal photoreceptor inner segment morphology 0.102382746082689 0.297228973012073 1.1702786377709 0.421052631578947 25.1 25 1 Leydig cell hypoplasia 0.102382746082689 0.297228973012073 1.1702786377709 0.421052631578947 25.1 25 1 thin interventricular septum 0.102382746082689 0.297228973012073 1.1702786377709 0.421052631578947 25.1 25 1 increased T cell proliferation 0.000331398444257868 0.00424924551593529 1.16891148982958 0.420560747663551 25.1 25 1 increased T cell number 0.00107948675161879 0.0106556479946497 1.16861631016043 0.420454545454545 25.1 25 1 decreased grip strength 4.13782168843159e-07 1.42955992360744e-05 1.16760676873489 0.420091324200913 25.1 25 1 testicular atrophy 0.0122493313614464 0.0694082272473756 1.16735294117647 0.42 25.1 25 1 abnormal spleen morphology 6.47836358385781e-06 0.00016360334431316 1.16607505070994 0.419540229885057 25.1 25 1 osteopetrosis 0.0443958056268582 0.175584954446011 1.16555977229602 0.419354838709677 25.1 25 1 abnormal cranial ganglia morphology 0.0443958056268582 0.175584954446011 1.16555977229602 0.419354838709677 25.1 25 1 abnormal nose morphology 0.0443958056268582 0.175584954446011 1.16555977229602 0.419354838709677 25.1 25 1 decreased double-negative T cell number 0.0443958056268582 0.175584954446011 1.16555977229602 0.419354838709677 25.1 25 1 abnormal T cell proliferation 0.0443958056268582 0.175584954446011 1.16555977229602 0.419354838709677 25.1 25 1 increased B cell number 0.000208799516066228 0.00280750700656617 1.16402714932127 0.418803418803419 25.1 25 1 increased circulating insulin level 1.63254469971176e-05 0.000353126516568087 1.16387867647059 0.41875 25.1 25 1 abnormal axon guidance 0.0203124159874325 0.0948866380633582 1.16347469220246 0.418604651162791 25.1 25 1 increased sensitivity to xenobiotic induced morbidity/mortality 0.000334015827307538 0.00426084292526924 1.16229946524064 0.418181818181818 25.1 25 1 maternal effect 0.00458103447561858 0.0328869358098159 1.16154521510097 0.417910447761194 25.1 25 1 decreased B cell number 1.32041800856059e-06 4.05498740283267e-05 1.16033695031411 0.41747572815534 25.1 25 1 no abnormal phenotype detected 1.18494599041491e-45 1.96503543410472e-42 1.15982369893202 0.417291066282421 25.1 25 1 abnormal osteoclast morphology 0.0157668001797053 0.0833579499405248 1.15808823529412 0.416666666666667 25.1 25 1 abnormal primitive streak formation 0.0765876671840376 0.239186217351279 1.15808823529412 0.416666666666667 25.1 25 1 decreased ovulation rate 0.0765876671840376 0.239186217351279 1.15808823529412 0.416666666666667 25.1 25 1 increased hemangiosarcoma incidence 0.0765876671840376 0.239186217351279 1.15808823529412 0.416666666666667 25.1 25 1 abnormal retinal ganglion layer morphology 0.0765876671840376 0.239186217351279 1.15808823529412 0.416666666666667 25.1 25 1 abnormal mineral level 0.189164561071375 0.447242346656551 1.15808823529412 0.416666666666667 25.1 25 1 abnormal rectum morphology 0.189164561071375 0.447242346656551 1.15808823529412 0.416666666666667 25.1 25 1 abnormal superior cervical ganglion morphology 0.189164561071375 0.447242346656551 1.15808823529412 0.416666666666667 25.1 25 1 absent optic nerve 0.189164561071375 0.447242346656551 1.15808823529412 0.416666666666667 25.1 25 1 altered tumor susceptibility 0.189164561071375 0.447242346656551 1.15808823529412 0.416666666666667 25.1 25 1 decreased synaptic depression 0.189164561071375 0.447242346656551 1.15808823529412 0.416666666666667 25.1 25 1 abnormal gastrocnemius morphology 0.189164561071375 0.447242346656551 1.15808823529412 0.416666666666667 25.1 25 1 dilated bile duct 0.189164561071375 0.447242346656551 1.15808823529412 0.416666666666667 25.1 25 1 delayed somite formation 0.189164561071375 0.447242346656551 1.15808823529412 0.416666666666667 25.1 25 1 abnormal B cell proliferation 0.189164561071375 0.447242346656551 1.15808823529412 0.416666666666667 25.1 25 1 abnormal patella morphology 0.189164561071375 0.447242346656551 1.15808823529412 0.416666666666667 25.1 25 1 hemoperitoneum 0.189164561071375 0.447242346656551 1.15808823529412 0.416666666666667 25.1 25 1 abnormal colon goblet cell morphology 0.189164561071375 0.447242346656551 1.15808823529412 0.416666666666667 25.1 25 1 abnormal vitelline vein connection 0.189164561071375 0.447242346656551 1.15808823529412 0.416666666666667 25.1 25 1 abnormal pharyngeal arch morphology 0.0340422699869579 0.144011274321975 1.15808823529412 0.416666666666667 25.1 25 1 narrow eye opening 0.0340422699869579 0.144011274321975 1.15808823529412 0.416666666666667 25.1 25 1 abnormal T cell differentiation 0.000679423136234477 0.00716129259060704 1.15579499126383 0.415841584158416 25.1 25 1 polyuria 0.0028310381274403 0.0224832362457236 1.15508021390374 0.415584415584416 25.1 25 1 abnormal lipid homeostasis 0.00013233630277016 0.00194827488973472 1.15452488687783 0.415384615384615 25.1 25 1 liver fibrosis 0.0262250418797869 0.116386782651151 1.15243902439024 0.414634146341463 25.1 25 1 increased tumor growth/size 0.0262250418797869 0.116386782651151 1.15243902439024 0.414634146341463 25.1 25 1 increased circulating triglyceride level 6.62464655991861e-05 0.00111720734357949 1.1501014198783 0.413793103448276 25.1 25 1 glomerulosclerosis 0.00956848011967135 0.0575612921346614 1.1501014198783 0.413793103448276 25.1 25 1 abnormal microglial cell morphology 0.0579118262543226 0.210111049149934 1.1501014198783 0.413793103448276 25.1 25 1 decreased granulocyte number 0.0579118262543226 0.210111049149934 1.1501014198783 0.413793103448276 25.1 25 1 abnormal CD8-positive, alpha-beta T cell physiology 0.0579118262543226 0.210111049149934 1.1501014198783 0.413793103448276 25.1 25 1 decreased bone strength 0.0579118262543226 0.210111049149934 1.1501014198783 0.413793103448276 25.1 25 1 abnormal immune system morphology 0.0202795525751332 0.0948221560726389 1.1480179028133 0.41304347826087 25.1 25 1 skin lesions 0.0074762865715345 0.046844490797713 1.14705882352941 0.412698412698413 25.1 25 1 decreased susceptibility to hepatic steatosis 0.0074762865715345 0.046844490797713 1.14705882352941 0.412698412698413 25.1 25 1 postnatal lethality, complete penetrance 1.9351769084227e-10 1.50429767490671e-08 1.1448872295032 0.411917098445596 25.1 25 1 distended abdomen 0.0157313330609072 0.0832589169978865 1.14446366782007 0.411764705882353 25.1 25 1 abnormal gastrulation 0.0157313330609072 0.0832589169978865 1.14446366782007 0.411764705882353 25.1 25 1 impaired synaptic plasticity 0.0441337961559722 0.175584954446011 1.14446366782007 0.411764705882353 25.1 25 1 abnormal brown adipose tissue morphology 0.0441337961559722 0.175584954446011 1.14446366782007 0.411764705882353 25.1 25 1 abnormal bone remodeling 0.0441337961559722 0.175584954446011 1.14446366782007 0.411764705882353 25.1 25 1 increased width of hypertrophic chondrocyte zone 0.0441337961559722 0.175584954446011 1.14446366782007 0.411764705882353 25.1 25 1 decreased regulatory T cell number 0.0441337961559722 0.175584954446011 1.14446366782007 0.411764705882353 25.1 25 1 abnormal glutamate-mediated receptor currents 0.136454659735616 0.367150855697506 1.14446366782007 0.411764705882353 25.1 25 1 aminoaciduria 0.136454659735616 0.367150855697506 1.14446366782007 0.411764705882353 25.1 25 1 pancytopenia 0.136454659735616 0.367150855697506 1.14446366782007 0.411764705882353 25.1 25 1 increased circulating magnesium level 0.136454659735616 0.367150855697506 1.14446366782007 0.411764705882353 25.1 25 1 common atrium 0.136454659735616 0.367150855697506 1.14446366782007 0.411764705882353 25.1 25 1 decreased body fat mass 0.136454659735616 0.367150855697506 1.14446366782007 0.411764705882353 25.1 25 1 reduced long term potentiation 0.000538781613013201 0.00621911490659089 1.14154411764706 0.410714285714286 25.1 25 1 abnormal neuron differentiation 0.000538781613013201 0.00621911490659089 1.14154411764706 0.410714285714286 25.1 25 1 abnormal seminal vesicle morphology 0.0122355681377891 0.0694082272473756 1.14154411764706 0.410714285714286 25.1 25 1 absent gastric milk in neonates 0.00359926239713826 0.0273424331153251 1.14027149321267 0.41025641025641 25.1 25 1 abnormal circulating hormone level 0.0338348855377889 0.144011274321975 1.14027149321267 0.41025641025641 25.1 25 1 increased anxiety-related response 0.000132955175683929 0.00195118583783938 1.13975878121033 0.410071942446043 25.1 25 1 decreased macrophage cell number 0.0260617535518083 0.115972472200578 1.1370320855615 0.409090909090909 25.1 25 1 decreased blood urea nitrogen level 0.0260617535518083 0.115972472200578 1.1370320855615 0.409090909090909 25.1 25 1 abnormal basisphenoid bone morphology 0.100776671279465 0.295901394336895 1.1370320855615 0.409090909090909 25.1 25 1 abnormal long bone epiphysis morphology 0.100776671279465 0.295901394336895 1.1370320855615 0.409090909090909 25.1 25 1 abnormal enterocyte morphology 0.100776671279465 0.295901394336895 1.1370320855615 0.409090909090909 25.1 25 1 increased coping response 0.100776671279465 0.295901394336895 1.1370320855615 0.409090909090909 25.1 25 1 abnormal lysosome physiology 0.100776671279465 0.295901394336895 1.1370320855615 0.409090909090909 25.1 25 1 abnormal cochlear sensory epithelium morphology 0.100776671279465 0.295901394336895 1.1370320855615 0.409090909090909 25.1 25 1 abnormal female reproductive system physiology 0.100776671279465 0.295901394336895 1.1370320855615 0.409090909090909 25.1 25 1 prolonged PR interval 0.100776671279465 0.295901394336895 1.1370320855615 0.409090909090909 25.1 25 1 abnormal limb posture 0.100776671279465 0.295901394336895 1.1370320855615 0.409090909090909 25.1 25 1 azoospermia 5.26601936456351e-05 0.000952670775952853 1.13623751387347 0.408805031446541 25.1 25 1 hydroencephaly 0.000537768766768159 0.00621911490659089 1.13593350383632 0.408695652173913 25.1 25 1 atelectasis 0.00582906152111508 0.0384609828482062 1.13525269262635 0.408450704225352 25.1 25 1 liver inflammation 0.000425213728621253 0.00523623341557112 1.13492647058824 0.408333333333333 25.1 25 1 decreased urine osmolality 0.0201512513414063 0.094310889391812 1.13445378151261 0.408163265306122 25.1 25 1 abnormal craniofacial development 0.0201512513414063 0.094310889391812 1.13445378151261 0.408163265306122 25.1 25 1 diluted coat color 0.0156305786699133 0.0829020563782715 1.13235294117647 0.407407407407407 25.1 25 1 polyphagia 0.0156305786699133 0.0829020563782715 1.13235294117647 0.407407407407407 25.1 25 1 abnormal colon morphology 0.012156430264201 0.0690390874022832 1.13060817547358 0.406779661016949 25.1 25 1 abnormal behavior 1.72895991360267e-07 6.37153745938762e-06 1.12976089716462 0.406474820143885 25.1 25 1 enlarged spleen 1.09642897897189e-07 4.3313044868419e-06 1.12913602941176 0.40625 25.1 25 1 increased sacral vertebrae number 0.0094760215089535 0.0572126298629171 1.12913602941176 0.40625 25.1 25 1 increased dopamine level 0.0571813412577412 0.210111049149934 1.12913602941176 0.40625 25.1 25 1 abnormal lumbar vertebrae morphology 0.0571813412577412 0.210111049149934 1.12913602941176 0.40625 25.1 25 1 bradykinesia 0.0571813412577412 0.210111049149934 1.12913602941176 0.40625 25.1 25 1 abnormal serotonin level 0.0571813412577412 0.210111049149934 1.12913602941176 0.40625 25.1 25 1 increased lymphocyte cell number 0.00740117069173961 0.0465497145276922 1.12787723785166 0.405797101449275 25.1 25 1 decreased IgG level 0.000854317224281093 0.00872736794825141 1.12678855325914 0.405405405405405 25.1 25 1 increased white adipose tissue amount 0.04361535132649 0.175584954446011 1.12678855325914 0.405405405405405 25.1 25 1 abnormal breathing pattern 0.04361535132649 0.175584954446011 1.12678855325914 0.405405405405405 25.1 25 1 decreased circulating chloride level 0.04361535132649 0.175584954446011 1.12678855325914 0.405405405405405 25.1 25 1 abnormal calcium ion homeostasis 0.04361535132649 0.175584954446011 1.12678855325914 0.405405405405405 25.1 25 1 abnormal spatial learning 6.5641854917888e-05 0.00111077628645066 1.12540599061711 0.404907975460123 25.1 25 1 disheveled coat 0.0334591956490018 0.143252580338885 1.125 0.404761904761905 25.1 25 1 abnormal reproductive system morphology 0.0334591956490018 0.143252580338885 1.125 0.404761904761905 25.1 25 1 increased startle reflex 0.00279657919068591 0.0224402926994555 1.12425644415069 0.404494382022472 25.1 25 1 abnormal skin condition 0.019945356824915 0.0937876622786646 1.12245475113122 0.403846153846154 25.1 25 1 increased susceptibility to injury 0.019945356824915 0.0937876622786646 1.12245475113122 0.403846153846154 25.1 25 1 abnormal response/metabolism to endogenous compounds 0.00449664330841885 0.0325630283251583 1.118543758967 0.402439024390244 25.1 25 1 male infertility 1.17827687256966e-11 1.22123488354876e-09 1.11618524149222 0.401590457256461 25.1 25 1 increased or absent threshold for auditory brainstem response 2.62102894523739e-07 9.38102086514823e-06 1.11561164258091 0.401384083044983 25.1 25 1 alopecia 0.00274278346755678 0.0220441805348869 1.11176470588235 0.4 25.1 25 1 abnormal retinal pigment epithelium morphology 0.00567312825211354 0.0379811232400374 1.11176470588235 0.4 25.1 25 1 abnormal cartilage development 0.032953768500311 0.141820932775993 1.11176470588235 0.4 25.1 25 1 irregular heartbeat 0.032953768500311 0.141820932775993 1.11176470588235 0.4 25.1 25 1 albuminuria 0.032953768500311 0.141820932775993 1.11176470588235 0.4 25.1 25 1 holoprosencephaly 0.0561636862430932 0.210111049149934 1.11176470588235 0.4 25.1 25 1 decreased triglyceride level 0.0561636862430932 0.210111049149934 1.11176470588235 0.4 25.1 25 1 abnormal cell proliferation 0.132666256500243 0.36404557423536 1.11176470588235 0.4 25.1 25 1 small gonad 0.132666256500243 0.36404557423536 1.11176470588235 0.4 25.1 25 1 brain inflammation 0.132666256500243 0.36404557423536 1.11176470588235 0.4 25.1 25 1 abnormal hair texture 0.132666256500243 0.36404557423536 1.11176470588235 0.4 25.1 25 1 abnormal Peyer's patch T cell area morphology 0.132666256500243 0.36404557423536 1.11176470588235 0.4 25.1 25 1 decreased paired-pulse facilitation 0.132666256500243 0.36404557423536 1.11176470588235 0.4 25.1 25 1 abnormal hyoid bone morphology 0.132666256500243 0.36404557423536 1.11176470588235 0.4 25.1 25 1 absent placental labyrinth 0.132666256500243 0.36404557423536 1.11176470588235 0.4 25.1 25 1 abnormal sperm mitochondrial sheath morphology 0.132666256500243 0.36404557423536 1.11176470588235 0.4 25.1 25 1 abnormal long bone epiphyseal plate morphology 0.0152766154070799 0.0819906456499647 1.11176470588235 0.4 25.1 25 1 decreased respiratory quotient 0.0254191979947129 0.115594616109412 1.11176470588235 0.4 25.1 25 1 salivary gland inflammation 0.0740249423299894 0.234202747395479 1.11176470588235 0.4 25.1 25 1 liver hemorrhage 0.0740249423299894 0.234202747395479 1.11176470588235 0.4 25.1 25 1 mandible hypoplasia 0.0984635915143168 0.291407714327023 1.11176470588235 0.4 25.1 25 1 abnormal cochlear outer hair cell morphology 0.0984635915143168 0.291407714327023 1.11176470588235 0.4 25.1 25 1 interdigital webbing 0.182284736632112 0.442589831500614 1.11176470588235 0.4 25.1 25 1 abnormal prostate gland morphology 0.182284736632112 0.442589831500614 1.11176470588235 0.4 25.1 25 1 hyperpigmentation 0.182284736632112 0.442589831500614 1.11176470588235 0.4 25.1 25 1 increased airway responsiveness 0.182284736632112 0.442589831500614 1.11176470588235 0.4 25.1 25 1 altered righting response 0.182284736632112 0.442589831500614 1.11176470588235 0.4 25.1 25 1 joint inflammation 0.182284736632112 0.442589831500614 1.11176470588235 0.4 25.1 25 1 abnormal olfactory nerve morphology 0.182284736632112 0.442589831500614 1.11176470588235 0.4 25.1 25 1 abnormal zygomatic bone morphology 0.182284736632112 0.442589831500614 1.11176470588235 0.4 25.1 25 1 abnormal dendritic cell morphology 0.182284736632112 0.442589831500614 1.11176470588235 0.4 25.1 25 1 abnormal secondary palate development 0.182284736632112 0.442589831500614 1.11176470588235 0.4 25.1 25 1 decreased trabecular bone mass 0.182284736632112 0.442589831500614 1.11176470588235 0.4 25.1 25 1 decreased brown adipose tissue mass 0.182284736632112 0.442589831500614 1.11176470588235 0.4 25.1 25 1 improved glucose tolerance 3.11619466684583e-05 0.000591720170517481 1.10609243697479 0.397959183673469 25.1 25 1 dermatitis 0.0193577708149288 0.0923484520036883 1.10218052738337 0.396551724137931 25.1 25 1 thrombocytosis 0.0193577708149288 0.0923484520036883 1.10218052738337 0.396551724137931 25.1 25 1 increased circulating bilirubin level 0.0249827431309392 0.114026740437085 1.10127635960044 0.39622641509434 25.1 25 1 small ovary 0.00432588643506331 0.0314179343276496 1.09954751131222 0.395604395604396 25.1 25 1 abnormal left-right axis patterning 0.0420551669661819 0.172059585244042 1.09883720930233 0.395348837209302 25.1 25 1 increased exploration in new environment 0.00703749566546102 0.0446575777240671 1.09803921568627 0.395061728395062 25.1 25 1 abnormal retinal outer nuclear layer morphology 0.0549431391306622 0.206451750132209 1.09713622291022 0.394736842105263 25.1 25 1 abnormal skin morphology 0.0147763204637359 0.0797312302679892 1.09491978609626 0.393939393939394 25.1 25 1 dextrocardia 0.0722282251355784 0.23034321798045 1.09491978609626 0.393939393939394 25.1 25 1 decreased brown adipose tissue amount 0.0722282251355784 0.23034321798045 1.09491978609626 0.393939393939394 25.1 25 1 abnormal middle ear ossicle morphology 0.0722282251355784 0.23034321798045 1.09491978609626 0.393939393939394 25.1 25 1 decreased startle reflex 0.00160709392740759 0.0144319355394454 1.09276018099548 0.393162393162393 25.1 25 1 increased neutrophil cell number 0.000486685656095494 0.00582064893902554 1.09259634888438 0.393103448275862 25.1 25 1 abnormal eye development 0.0244916029257145 0.111887717681754 1.09191176470588 0.392857142857143 25.1 25 1 enhanced long term potentiation 0.0244916029257145 0.111887717681754 1.09191176470588 0.392857142857143 25.1 25 1 decreased circulating progesterone level 0.0957246741067948 0.285359422850479 1.09191176470588 0.392857142857143 25.1 25 1 prolonged QRS complex duration 0.0957246741067948 0.285359422850479 1.09191176470588 0.392857142857143 25.1 25 1 decreased food intake 0.00883496012205382 0.053471930179097 1.09065524944155 0.392405063291139 25.1 25 1 increased kidney weight 0.0316694334358779 0.138505145577727 1.08996539792388 0.392156862745098 25.1 25 1 abnormal T cell activation 0.0113034864345289 0.0649363106371608 1.08922893481717 0.391891891891892 25.1 25 1 abnormal myocardial fiber morphology 0.00418217052490679 0.0305525673442163 1.08884172225591 0.391752577319588 25.1 25 1 blistering 0.128276765739607 0.354345868714349 1.08759590792839 0.391304347826087 25.1 25 1 increased susceptibility to age related obesity 0.128276765739607 0.354345868714349 1.08759590792839 0.391304347826087 25.1 25 1 dilated heart 0.128276765739607 0.354345868714349 1.08759590792839 0.391304347826087 25.1 25 1 increased susceptibility to fungal infection 0.128276765739607 0.354345868714349 1.08759590792839 0.391304347826087 25.1 25 1 abnormal lens morphology 0.00122546415974393 0.0119542827347569 1.08570772058824 0.390625 25.1 25 1 increased spleen weight 0.00249481981135138 0.020414027239265 1.08224882873503 0.389380530973451 25.1 25 1 underdeveloped hair follicles 0.174685291390714 0.426636880053412 1.08088235294118 0.388888888888889 25.1 25 1 abnormal stomach glandular epithelium morphology 0.174685291390714 0.426636880053412 1.08088235294118 0.388888888888889 25.1 25 1 right pulmonary isomerism 0.174685291390714 0.426636880053412 1.08088235294118 0.388888888888889 25.1 25 1 abnormal phrenic nerve morphology 0.174685291390714 0.426636880053412 1.08088235294118 0.388888888888889 25.1 25 1 abnormal thyroid cartilage morphology 0.174685291390714 0.426636880053412 1.08088235294118 0.388888888888889 25.1 25 1 abnormal thymus medulla morphology 0.174685291390714 0.426636880053412 1.08088235294118 0.388888888888889 25.1 25 1 abnormal Peyer's patch follicle morphology 0.174685291390714 0.426636880053412 1.08088235294118 0.388888888888889 25.1 25 1 acidosis 0.174685291390714 0.426636880053412 1.08088235294118 0.388888888888889 25.1 25 1 decreased activity of thyroid 0.174685291390714 0.426636880053412 1.08088235294118 0.388888888888889 25.1 25 1 absent ureter 0.174685291390714 0.426636880053412 1.08088235294118 0.388888888888889 25.1 25 1 abnormal macrophage chemotaxis 0.174685291390714 0.426636880053412 1.08088235294118 0.388888888888889 25.1 25 1 abnormal gait 1.2459325842767e-06 3.85000907253204e-05 1.07938320959452 0.388349514563107 25.1 25 1 abnormal social investigation 0.0108353027336487 0.0634183895292966 1.07702205882353 0.3875 25.1 25 1 small cranium 0.0927380813003877 0.279788935396864 1.07590132827324 0.387096774193548 25.1 25 1 abnormal motor capabilities/coordination/movement 0.00146273134189535 0.013476089677647 1.07386363636364 0.386363636363636 25.1 25 1 hypertension 0.0521250939307876 0.197053451600052 1.07386363636364 0.386363636363636 25.1 25 1 abnormal photoreceptor outer segment morphology 0.0521250939307876 0.197053451600052 1.07386363636364 0.386363636363636 25.1 25 1 lethality, incomplete penetrance 0.0521250939307876 0.197053451600052 1.07386363636364 0.386363636363636 25.1 25 1 increased leukocyte cell number 0.000896272357299889 0.00913720282288309 1.07342799188641 0.386206896551724 25.1 25 1 abnormal urine homeostasis 0.00636587425868767 0.0408648057251241 1.07123161764706 0.385416666666667 25.1 25 1 decreased monocyte cell number 0.0228074643246018 0.105257082574113 1.06900452488688 0.384615384615385 25.1 25 1 decreased IgA level 0.0389969813177296 0.160604289781213 1.06900452488688 0.384615384615385 25.1 25 1 abnormal lens fiber morphology 0.0681357976262079 0.223964242677283 1.06900452488688 0.384615384615385 25.1 25 1 abnormal response to injury 0.0681357976262079 0.223964242677283 1.06900452488688 0.384615384615385 25.1 25 1 no spontaneous movement 0.12360410180439 0.342388867748797 1.06900452488688 0.384615384615385 25.1 25 1 abnormal mast cell morphology 0.24408586971137 0.501081999410492 1.06900452488688 0.384615384615385 25.1 25 1 uterus hypoplasia 0.24408586971137 0.501081999410492 1.06900452488688 0.384615384615385 25.1 25 1 abnormal grip strength 0.24408586971137 0.501081999410492 1.06900452488688 0.384615384615385 25.1 25 1 absent lateral semicircular canal 0.24408586971137 0.501081999410492 1.06900452488688 0.384615384615385 25.1 25 1 decreased alcohol consumption 0.24408586971137 0.501081999410492 1.06900452488688 0.384615384615385 25.1 25 1 abnormal insulin secretion 0.24408586971137 0.501081999410492 1.06900452488688 0.384615384615385 25.1 25 1 abnormal vestibulocochlear ganglion morphology 0.24408586971137 0.501081999410492 1.06900452488688 0.384615384615385 25.1 25 1 decreased endocochlear potential 0.24408586971137 0.501081999410492 1.06900452488688 0.384615384615385 25.1 25 1 increased circulating ammonia level 0.24408586971137 0.501081999410492 1.06900452488688 0.384615384615385 25.1 25 1 small pituitary gland 0.24408586971137 0.501081999410492 1.06900452488688 0.384615384615385 25.1 25 1 total cataracts 0.24408586971137 0.501081999410492 1.06900452488688 0.384615384615385 25.1 25 1 abnormal hair follicle inner root sheath morphology 0.24408586971137 0.501081999410492 1.06900452488688 0.384615384615385 25.1 25 1 epidermal hyperplasia 0.0293555535759677 0.12878648945365 1.06544117647059 0.383333333333333 25.1 25 1 abnormal eye physiology 0.0293555535759677 0.12878648945365 1.06544117647059 0.383333333333333 25.1 25 1 increased circulating glucose level 0.00136880822544422 0.0128004152661372 1.06445556946183 0.382978723404255 25.1 25 1 abnormal oocyte morphology 0.0896200145039059 0.27103925359084 1.06271626297578 0.382352941176471 25.1 25 1 abnormal endoderm development 0.0896200145039059 0.27103925359084 1.06271626297578 0.382352941176471 25.1 25 1 abnormal spleen red pulp morphology 0.0896200145039059 0.27103925359084 1.06271626297578 0.382352941176471 25.1 25 1 abnormal direction of heart looping 0.0896200145039059 0.27103925359084 1.06271626297578 0.382352941176471 25.1 25 1 increased susceptibility to weight gain 0.0896200145039059 0.27103925359084 1.06271626297578 0.382352941176471 25.1 25 1 abnormal skin physiology 0.0896200145039059 0.27103925359084 1.06271626297578 0.382352941176471 25.1 25 1 decreased anxiety-related response 0.00283356565348114 0.0224832362457236 1.06205164992826 0.382113821138211 25.1 25 1 abnormal vibrissa morphology 0.0659646309356863 0.223964242677283 1.05882352941176 0.380952380952381 25.1 25 1 abnormal hematopoietic system physiology 0.166932674611657 0.425161974386872 1.05882352941176 0.380952380952381 25.1 25 1 abnormal erythrocyte physiology 0.166932674611657 0.425161974386872 1.05882352941176 0.380952380952381 25.1 25 1 decreased vocalization 0.166932674611657 0.425161974386872 1.05882352941176 0.380952380952381 25.1 25 1 increased circulating chloride level 0.049056629649734 0.187447567210005 1.05617647058824 0.38 25.1 25 1 abnormal retinal pigmentation 0.0124995726424711 0.0707455903257038 1.05425963488844 0.379310344827586 25.1 25 1 abnormal enzyme/coenzyme level 0.0367592232356095 0.152779561902387 1.05425963488844 0.379310344827586 25.1 25 1 abnormal middle ear morphology 0.118832525572194 0.331306520662757 1.05425963488844 0.379310344827586 25.1 25 1 increased double-positive T cell number 0.118832525572194 0.331306520662757 1.05425963488844 0.379310344827586 25.1 25 1 polychromatophilia 0.118832525572194 0.331306520662757 1.05425963488844 0.379310344827586 25.1 25 1 increased retinal apoptosis 0.118832525572194 0.331306520662757 1.05425963488844 0.379310344827586 25.1 25 1 decreased birth weight 0.00955053380209579 0.0575228882148021 1.05325077399381 0.378947368421053 25.1 25 1 abnormal developmental patterning 0.0159412246884872 0.0841906505575623 1.05075322812052 0.378048780487805 25.1 25 1 abnormal autopod morphology 0.0637648272278625 0.221066212863147 1.05 0.377777777777778 25.1 25 1 abnormal coat/ hair morphology 0.0474904590066939 0.181602639168564 1.0488346281909 0.377358490566038 25.1 25 1 abnormal posture 0.0197432447298214 0.09310203083494 1.04227941176471 0.375 25.1 25 1 decreased circulating LDL cholesterol level 0.0344905647914103 0.144011274321975 1.04227941176471 0.375 25.1 25 1 abnormal kidney physiology 0.0615634816453508 0.21373225483993 1.04227941176471 0.375 25.1 25 1 abnormal lymph node morphology 0.0615634816453508 0.21373225483993 1.04227941176471 0.375 25.1 25 1 thymus atrophy 0.0615634816453508 0.21373225483993 1.04227941176471 0.375 25.1 25 1 abnormal lymphatic vessel morphology 0.114072125325976 0.328229510408751 1.04227941176471 0.375 25.1 25 1 abnormal diaphragm morphology 0.114072125325976 0.328229510408751 1.04227941176471 0.375 25.1 25 1 abnormal malleus morphology 0.159290224872948 0.419739866918918 1.04227941176471 0.375 25.1 25 1 abnormal adrenal gland morphology 0.159290224872948 0.419739866918918 1.04227941176471 0.375 25.1 25 1 abnormal nursing 0.159290224872948 0.419739866918918 1.04227941176471 0.375 25.1 25 1 hemolytic anemia 0.159290224872948 0.419739866918918 1.04227941176471 0.375 25.1 25 1 small lymph nodes 0.159290224872948 0.419739866918918 1.04227941176471 0.375 25.1 25 1 increased circulating total protein level 0.159290224872948 0.419739866918918 1.04227941176471 0.375 25.1 25 1 abnormal tympanic ring morphology 0.229963390162683 0.501081999410492 1.04227941176471 0.375 25.1 25 1 disorganized retinal layers 0.229963390162683 0.501081999410492 1.04227941176471 0.375 25.1 25 1 white spotting 0.229963390162683 0.501081999410492 1.04227941176471 0.375 25.1 25 1 decreased aggression towards mice 0.229963390162683 0.501081999410492 1.04227941176471 0.375 25.1 25 1 abnormal molar crown morphology 0.229963390162683 0.501081999410492 1.04227941176471 0.375 25.1 25 1 small epididymis 0.229963390162683 0.501081999410492 1.04227941176471 0.375 25.1 25 1 abnormal intestinal lipid absorption 0.229963390162683 0.501081999410492 1.04227941176471 0.375 25.1 25 1 decreased skeletal muscle weight 0.229963390162683 0.501081999410492 1.04227941176471 0.375 25.1 25 1 increased heart left ventricle size 0.229963390162683 0.501081999410492 1.04227941176471 0.375 25.1 25 1 abnormal excitatory postsynaptic currents 0.0244005315423602 0.111676765798751 1.03337104072398 0.371794871794872 25.1 25 1 increased bone mineral density 0.0080053835979737 0.0497213275904109 1.03305570015617 0.371681415929204 25.1 25 1 abnormal action potential 0.0322540650885307 0.140511360608967 1.03235294117647 0.371428571428571 25.1 25 1 abnormal intestinal goblet cell morphology 0.109389663021659 0.315486129584205 1.03235294117647 0.371428571428571 25.1 25 1 hyporesponsive to tactile stimuli 0.104825578963296 0.302498407971229 1.02399380804954 0.368421052631579 25.1 25 1 decreased threshold for auditory brainstem response 0.104825578963296 0.302498407971229 1.02399380804954 0.368421052631579 25.1 25 1 shiny skin 0.216861776153728 0.495445513299698 1.02399380804954 0.368421052631579 25.1 25 1 stereotypic behavior 0.216861776153728 0.495445513299698 1.02399380804954 0.368421052631579 25.1 25 1 abnormal long term depression 0.216861776153728 0.495445513299698 1.02399380804954 0.368421052631579 25.1 25 1 decreased tumor incidence 0.216861776153728 0.495445513299698 1.02399380804954 0.368421052631579 25.1 25 1 increased liver adenoma incidence 0.216861776153728 0.495445513299698 1.02399380804954 0.368421052631579 25.1 25 1 increased left ventricle weight 0.216861776153728 0.495445513299698 1.02399380804954 0.368421052631579 25.1 25 1 abnormal cochlear inner hair cell morphology 0.216861776153728 0.495445513299698 1.02399380804954 0.368421052631579 25.1 25 1 increased circulating LDL cholesterol level 0.0740410096595912 0.234202747395479 1.02100840336134 0.36734693877551 25.1 25 1 abnormal epidermis stratum corneum morphology 0.0740410096595912 0.234202747395479 1.02100840336134 0.36734693877551 25.1 25 1 increased fluid intake 0.0740410096595912 0.234202747395479 1.02100840336134 0.36734693877551 25.1 25 1 abnormal estrous cycle 0.144773757975577 0.383723732513848 1.01911764705882 0.366666666666667 25.1 25 1 decreased body temperature 0.0711161145409727 0.227233570867912 1.01555429864253 0.365384615384615 25.1 25 1 abnormal suckling behavior 0.0260487730200191 0.115972472200578 1.01069518716578 0.363636363636364 25.1 25 1 abnormal rostral-caudal axis patterning 0.0682822063908997 0.223964242677283 1.01069518716578 0.363636363636364 25.1 25 1 abnormal myelopoiesis 0.0961378354603523 0.285359422850479 1.01069518716578 0.363636363636364 25.1 25 1 muscular atrophy 0.0961378354603523 0.285359422850479 1.01069518716578 0.363636363636364 25.1 25 1 abnormal amino acid level 0.0961378354603523 0.285359422850479 1.01069518716578 0.363636363636364 25.1 25 1 abnormal abdominal fat pad morphology 0.204736105087196 0.469816477310331 1.01069518716578 0.363636363636364 25.1 25 1 intestinal inflammation 0.204736105087196 0.469816477310331 1.01069518716578 0.363636363636364 25.1 25 1 abnormal oogenesis 0.204736105087196 0.469816477310331 1.01069518716578 0.363636363636364 25.1 25 1 abnormal chorion morphology 0.204736105087196 0.469816477310331 1.01069518716578 0.363636363636364 25.1 25 1 decreased cardiac output 0.204736105087196 0.469816477310331 1.01069518716578 0.363636363636364 25.1 25 1 abnormal mesenteric lymph node morphology 0.204736105087196 0.469816477310331 1.01069518716578 0.363636363636364 25.1 25 1 abnormal sperm midpiece morphology 0.204736105087196 0.469816477310331 1.01069518716578 0.363636363636364 25.1 25 1 rough coat 0.204736105087196 0.469816477310331 1.01069518716578 0.363636363636364 25.1 25 1 increased bone volume 0.204736105087196 0.469816477310331 1.01069518716578 0.363636363636364 25.1 25 1 hepatic necrosis 0.0920341231541745 0.278002284573174 1.00531914893617 0.361702127659574 25.1 25 1 increased respiratory quotient 0.0920341231541745 0.278002284573174 1.00531914893617 0.361702127659574 25.1 25 1 abnormal epidermis stratum granulosum morphology 0.131517195828088 0.362692931953847 1.00367647058824 0.361111111111111 25.1 25 1 reduced long term depression 0.131517195828088 0.362692931953847 1.00367647058824 0.361111111111111 25.1 25 1 impaired wound healing 0.131517195828088 0.362692931953847 1.00367647058824 0.361111111111111 25.1 25 1 enlarged liver 0.0224514194542872 0.104388609144933 1.00058823529412 0.36 25.1 25 1 abnormal nest building behavior 0.193505206137178 0.447242346656551 1.00058823529412 0.36 25.1 25 1 decreased B-1 B cell number 0.125371856512066 0.347092368473861 0.997737556561086 0.358974358974359 25.1 25 1 increased blood urea nitrogen level 0.00786150531837309 0.0488887361986327 0.996754563894523 0.358620689655172 25.1 25 1 abnormal pancreatic islet morphology 0.0843186867513054 0.257688699951836 0.996392896781354 0.358490566037736 25.1 25 1 increased total body fat amount 0.0105761087043617 0.0619742530084801 0.995610184372256 0.358208955223881 25.1 25 1 arrest of spermatogenesis 0.0387284966833816 0.15963071333871 0.992647058823529 0.357142857142857 25.1 25 1 decreased inflammatory response 0.0387284966833816 0.15963071333871 0.992647058823529 0.357142857142857 25.1 25 1 increased food intake 0.0387284966833816 0.15963071333871 0.992647058823529 0.357142857142857 25.1 25 1 abnormal optic nerve morphology 0.119536724540633 0.331306520662757 0.992647058823529 0.357142857142857 25.1 25 1 abnormal spleen white pulp morphology 0.119536724540633 0.331306520662757 0.992647058823529 0.357142857142857 25.1 25 1 increased triglyceride level 0.183084001930929 0.4440969817681 0.992647058823529 0.357142857142857 25.1 25 1 abnormal interparietal bone morphology 0.302430053955942 0.536013366024514 0.992647058823529 0.357142857142857 25.1 25 1 absent atrioventricular cushions 0.302430053955942 0.536013366024514 0.992647058823529 0.357142857142857 25.1 25 1 abnormal fluid regulation 0.302430053955942 0.536013366024514 0.992647058823529 0.357142857142857 25.1 25 1 abnormal antigen presentation 0.302430053955942 0.536013366024514 0.992647058823529 0.357142857142857 25.1 25 1 abnormal olfactory system physiology 0.302430053955942 0.536013366024514 0.992647058823529 0.357142857142857 25.1 25 1 abnormal voluntary movement 0.302430053955942 0.536013366024514 0.992647058823529 0.357142857142857 25.1 25 1 abnormal uterus development 0.302430053955942 0.536013366024514 0.992647058823529 0.357142857142857 25.1 25 1 lysosomal protein accumulation 0.302430053955942 0.536013366024514 0.992647058823529 0.357142857142857 25.1 25 1 abnormal iris pigmentation 0.302430053955942 0.536013366024514 0.992647058823529 0.357142857142857 25.1 25 1 spina bifida occulta 0.302430053955942 0.536013366024514 0.992647058823529 0.357142857142857 25.1 25 1 increased B cell proliferation 0.0772438269041473 0.240781979228153 0.989282153539382 0.355932203389831 25.1 25 1 increased circulating corticosterone level 0.113998805519657 0.328229510408751 0.988235294117647 0.355555555555556 25.1 25 1 lethality at weaning, complete penetrance 0.113998805519657 0.328229510408751 0.988235294117647 0.355555555555556 25.1 25 1 abnormal immune system physiology 0.0165610365000148 0.0860792512090277 0.986242884250474 0.354838709677419 25.1 25 1 absent mature ovarian follicles 0.17339338014693 0.425780881653986 0.986242884250474 0.354838709677419 25.1 25 1 decreased susceptibility to bacterial infection induced morbidity/mortality 0.17339338014693 0.425780881653986 0.986242884250474 0.354838709677419 25.1 25 1 abnormal excitatory postsynaptic potential 0.0470334125922339 0.179993252035665 0.982962697274032 0.353658536585366 25.1 25 1 abnormal CNS synaptic transmission 0.0316821820437092 0.138505145577727 0.982620320855615 0.353535353535354 25.1 25 1 decreased susceptibility to injury 0.0677520163538896 0.223964242677283 0.980968858131488 0.352941176470588 25.1 25 1 abnormal cued conditioning behavior 0.103757148513368 0.29976295810337 0.980968858131488 0.352941176470588 25.1 25 1 abnormal interatrial septum morphology 0.28096815221381 0.510798830961393 0.980968858131488 0.352941176470588 25.1 25 1 enlarged sebaceous gland 0.28096815221381 0.510798830961393 0.980968858131488 0.352941176470588 25.1 25 1 hyperlipidemia 0.28096815221381 0.510798830961393 0.980968858131488 0.352941176470588 25.1 25 1 abnormal ectoplacental cone morphology 0.28096815221381 0.510798830961393 0.980968858131488 0.352941176470588 25.1 25 1 decreased growth hormone level 0.28096815221381 0.510798830961393 0.980968858131488 0.352941176470588 25.1 25 1 abnormal electroretinogram waveform feature 0.28096815221381 0.510798830961393 0.980968858131488 0.352941176470588 25.1 25 1 increased cell proliferation 0.0990242552355593 0.292718758049262 0.977941176470588 0.351851851851852 25.1 25 1 impaired limb coordination 0.0990242552355593 0.292718758049262 0.977941176470588 0.351851851851852 25.1 25 1 increased thermal nociceptive threshold 0.0415142787523206 0.169986450035222 0.97737556561086 0.351648351648352 25.1 25 1 abnormal long bone metaphysis morphology 0.155929764666627 0.412194781730323 0.976550079491256 0.351351351351351 25.1 25 1 abnormal vocalization 0.155929764666627 0.412194781730323 0.976550079491256 0.351351351351351 25.1 25 1 abnormal female reproductive system morphology 0.148040067018838 0.391754964584425 0.972794117647059 0.35 25.1 25 1 head bobbing 0.148040067018838 0.391754964584425 0.972794117647059 0.35 25.1 25 1 abnormal vascular regression 0.262197825197912 0.501081999410492 0.972794117647059 0.35 25.1 25 1 waved hair 0.262197825197912 0.501081999410492 0.972794117647059 0.35 25.1 25 1 abnormal incus morphology 0.262197825197912 0.501081999410492 0.972794117647059 0.35 25.1 25 1 abnormal induced retinal neovascularization 0.262197825197912 0.501081999410492 0.972794117647059 0.35 25.1 25 1 nuclear cataracts 0.262197825197912 0.501081999410492 0.972794117647059 0.35 25.1 25 1 abnormal heart electrocardiography waveform feature 0.262197825197912 0.501081999410492 0.972794117647059 0.35 25.1 25 1 abnormal hair follicle morphology 0.0862107372022281 0.261682988151974 0.970588235294118 0.349206349206349 25.1 25 1 abnormal epidermal layer morphology 0.07869674701178 0.244850729445657 0.966751918158568 0.347826086956522 25.1 25 1 hyperkeratosis 0.07869674701178 0.244850729445657 0.966751918158568 0.347826086956522 25.1 25 1 abnormal coat appearance 0.07869674701178 0.244850729445657 0.966751918158568 0.347826086956522 25.1 25 1 abnormal sleep pattern 0.133704707977278 0.364316505454817 0.966751918158568 0.347826086956522 25.1 25 1 failure of embryo implantation 0.245514419405911 0.501081999410492 0.966751918158568 0.347826086956522 25.1 25 1 abnormal crista ampullaris morphology 0.245514419405911 0.501081999410492 0.966751918158568 0.347826086956522 25.1 25 1 decreased epididymis weight 0.245514419405911 0.501081999410492 0.966751918158568 0.347826086956522 25.1 25 1 impaired righting response 0.0459448845841024 0.175962895154665 0.965479876160991 0.347368421052632 25.1 25 1 increased susceptibility to bacterial infection induced morbidity/mortality 0.0752141717279134 0.237129597177674 0.965073529411765 0.347222222222222 25.1 25 1 increased circulating alanine transaminase level 0.0687478244695896 0.223964242677283 0.96210407239819 0.346153846153846 25.1 25 1 abnormal leukocyte cell number 0.230511673136889 0.501081999410492 0.96210407239819 0.346153846153846 25.1 25 1 abnormal stomach morphology 0.230511673136889 0.501081999410492 0.96210407239819 0.346153846153846 25.1 25 1 abnormal ocular fundus morphology 0.230511673136889 0.501081999410492 0.96210407239819 0.346153846153846 25.1 25 1 decreased circulating glycerol level 0.230511673136889 0.501081999410492 0.96210407239819 0.346153846153846 25.1 25 1 decreased circulating calcium level 0.11524922545913 0.331306520662757 0.960160427807487 0.345454545454545 25.1 25 1 abnormal nervous system electrophysiology 0.0628869837271733 0.218174856375653 0.959558823529412 0.345238095238095 25.1 25 1 abnormal circulating glucose level 0.216900568435526 0.495445513299698 0.95841784989858 0.344827586206897 25.1 25 1 increased susceptibility to induced arthritis 0.216900568435526 0.495445513299698 0.95841784989858 0.344827586206897 25.1 25 1 increased susceptibility to parasitic infection 0.057567818635385 0.210111049149934 0.957352941176471 0.344444444444444 25.1 25 1 increased circulating follicle stimulating hormone level 0.204466418386478 0.469816477310331 0.955422794117647 0.34375 25.1 25 1 decreased neuron apoptosis 0.182503941232358 0.442905906161455 0.950851393188854 0.342105263157895 25.1 25 1 arrested B cell differentiation 0.172740336008453 0.425161974386872 0.949067431850789 0.341463414634146 25.1 25 1 increased liver weight 0.0688976627248128 0.223964242677283 0.947526737967915 0.340909090909091 25.1 25 1 teratozoospermia 0.0688976627248128 0.223964242677283 0.947526737967915 0.340909090909091 25.1 25 1 abnormal circadian rhythm 0.163667091749745 0.425161974386872 0.947526737967915 0.340909090909091 25.1 25 1 abnormal lipid level 0.0860897469430181 0.261475269256114 0.937632884479093 0.337349397590361 25.1 25 1 increased circulating cholesterol level 0.0223391550758218 0.103963794669985 0.931734625668449 0.335227272727273 25.1 25 1 abnormal T cell subpopulation ratio 0.23770816486233 0.501081999410492 0.926470588235294 0.333333333333333 25.1 25 1 abnormal cochlea morphology 0.160370509027961 0.422362775232453 0.926470588235294 0.333333333333333 25.1 25 1 acanthosis 0.211069983592504 0.484127786248368 0.926470588235294 0.333333333333333 25.1 25 1 abnormal brain commissure morphology 0.269825388708465 0.510411144039777 0.926470588235294 0.333333333333333 25.1 25 1 cryptorchism 0.269825388708465 0.510411144039777 0.926470588235294 0.333333333333333 25.1 25 1 abnormal palate morphology 0.269825388708465 0.510411144039777 0.926470588235294 0.333333333333333 25.1 25 1 abnormal digestive system morphology 0.288626516672391 0.513744873146742 0.926470588235294 0.333333333333333 25.1 25 1 abnormal impulse conducting system conduction 0.288626516672391 0.513744873146742 0.926470588235294 0.333333333333333 25.1 25 1 abnormal tumor morphology 0.288626516672391 0.513744873146742 0.926470588235294 0.333333333333333 25.1 25 1 hypopigmentation 0.288626516672391 0.513744873146742 0.926470588235294 0.333333333333333 25.1 25 1 abnormal salivary gland morphology 0.30983040049104 0.547180064764971 0.926470588235294 0.333333333333333 25.1 25 1 abnormal associative learning 0.30983040049104 0.547180064764971 0.926470588235294 0.333333333333333 25.1 25 1 decreased cochlear outer hair cell number 0.30983040049104 0.547180064764971 0.926470588235294 0.333333333333333 25.1 25 1 increased acute inflammation 0.30983040049104 0.547180064764971 0.926470588235294 0.333333333333333 25.1 25 1 abnormal stapes morphology 0.30983040049104 0.547180064764971 0.926470588235294 0.333333333333333 25.1 25 1 abnormal bile salt homeostasis 0.30983040049104 0.547180064764971 0.926470588235294 0.333333333333333 25.1 25 1 increased keratinocyte proliferation 0.30983040049104 0.547180064764971 0.926470588235294 0.333333333333333 25.1 25 1 abnormal white adipose tissue morphology 0.334109582625358 0.584456812081982 0.926470588235294 0.333333333333333 25.1 25 1 abnormal glycogen homeostasis 0.334109582625358 0.584456812081982 0.926470588235294 0.333333333333333 25.1 25 1 decreased lactate dehydrogenase level 0.334109582625358 0.584456812081982 0.926470588235294 0.333333333333333 25.1 25 1 abnormal metanephric mesenchyme morphology 0.334109582625358 0.584456812081982 0.926470588235294 0.333333333333333 25.1 25 1 decreased fluid intake 0.334109582625358 0.584456812081982 0.926470588235294 0.333333333333333 25.1 25 1 increased circulating HDL cholesterol level 0.0706980052175372 0.226042786604915 0.926470588235294 0.333333333333333 25.1 25 1 arrested T cell differentiation 0.252963973665501 0.501081999410492 0.926470588235294 0.333333333333333 25.1 25 1 abnormal pain threshold 0.252963973665501 0.501081999410492 0.926470588235294 0.333333333333333 25.1 25 1 abnormal seizure response to electrical stimulation 0.362502712617857 0.619316962662719 0.926470588235294 0.333333333333333 25.1 25 1 increased alcohol consumption 0.362502712617857 0.619316962662719 0.926470588235294 0.333333333333333 25.1 25 1 abnormal rostral migratory stream morphology 0.362502712617857 0.619316962662719 0.926470588235294 0.333333333333333 25.1 25 1 abnormal trophectoderm morphology 0.362502712617857 0.619316962662719 0.926470588235294 0.333333333333333 25.1 25 1 absent chorion 0.362502712617857 0.619316962662719 0.926470588235294 0.333333333333333 25.1 25 1 lactation failure 0.362502712617857 0.619316962662719 0.926470588235294 0.333333333333333 25.1 25 1 bicuspid aortic valve 0.362502712617857 0.619316962662719 0.926470588235294 0.333333333333333 25.1 25 1 abnormal NK cell physiology 0.164073281386043 0.425161974386872 0.911282545805207 0.327868852459016 25.1 25 1 abnormal leukocyte migration 0.192434162379464 0.447242346656551 0.908653846153846 0.326923076923077 25.1 25 1 abnormal female meiosis 0.192434162379464 0.447242346656551 0.908653846153846 0.326923076923077 25.1 25 1 decreased circulating phosphate level 0.241417721202048 0.501081999410492 0.903308823529412 0.325 25.1 25 1 increased brown adipose tissue amount 0.256389282882038 0.501081999410492 0.901430842607313 0.324324324324324 25.1 25 1 decreased cytotoxic T cell cytolysis 0.272786433041369 0.510798830961393 0.899221453287197 0.323529411764706 25.1 25 1 increased eosinophil cell number 0.184893208762571 0.447242346656551 0.896584440227704 0.32258064516129 25.1 25 1 abnormal eye electrophysiology 0.0921241605564376 0.278105399738032 0.895843461351483 0.322314049586777 25.1 25 1 abnormal jaw morphology 0.31091341402414 0.54870316948212 0.893382352941176 0.321428571428571 25.1 25 1 abnormal retinal inner nuclear layer morphology 0.31091341402414 0.54870316948212 0.893382352941176 0.321428571428571 25.1 25 1 kidney inflammation 0.229650214124356 0.501081999410492 0.889411764705882 0.32 25.1 25 1 abnormal inner ear vestibule morphology 0.333389486336021 0.584224267179184 0.889411764705882 0.32 25.1 25 1 abnormal food intake 0.186509233623071 0.447242346656551 0.88618925831202 0.318840579710145 25.1 25 1 abnormal locomotor activation 0.146617297724325 0.38840311830592 0.885746606334842 0.318681318681319 25.1 25 1 cochlear hair cell degeneration 0.257550239343774 0.501081999410492 0.884358288770054 0.318181818181818 25.1 25 1 abnormal blood-brain barrier function 0.358874405012833 0.614807219331558 0.884358288770054 0.318181818181818 25.1 25 1 abnormal temporal bone morphology 0.358874405012833 0.614807219331558 0.884358288770054 0.318181818181818 25.1 25 1 decreased susceptibility to viral infection induced morbidity/mortality 0.358874405012833 0.614807219331558 0.884358288770054 0.318181818181818 25.1 25 1 impaired natural killer cell mediated cytotoxicity 0.230368334698965 0.501081999410492 0.877708978328173 0.315789473684211 25.1 25 1 increased grooming behavior 0.290490209797275 0.516692453965478 0.877708978328173 0.315789473684211 25.1 25 1 abnormal nail morphology 0.388223954843033 0.655338551538649 0.877708978328173 0.315789473684211 25.1 25 1 altered susceptibility to infection 0.388223954843033 0.655338551538649 0.877708978328173 0.315789473684211 25.1 25 1 abnormal nasal septum morphology 0.388223954843033 0.655338551538649 0.877708978328173 0.315789473684211 25.1 25 1 increased susceptibility to ischemic brain injury 0.388223954843033 0.655338551538649 0.877708978328173 0.315789473684211 25.1 25 1 absent amnion 0.388223954843033 0.655338551538649 0.877708978328173 0.315789473684211 25.1 25 1 shortened RR interval 0.388223954843033 0.655338551538649 0.877708978328173 0.315789473684211 25.1 25 1 right-sided stomach 0.388223954843033 0.655338551538649 0.877708978328173 0.315789473684211 25.1 25 1 impaired behavioral response to xenobiotic 0.309334921248714 0.547180064764971 0.873529411764706 0.314285714285714 25.1 25 1 abnormal long term potentiation 0.330122147982682 0.578702496904103 0.868566176470588 0.3125 25.1 25 1 failure of tooth eruption 0.42274785918839 0.680494616484822 0.868566176470588 0.3125 25.1 25 1 abnormal extraembryonic endoderm formation 0.42274785918839 0.680494616484822 0.868566176470588 0.3125 25.1 25 1 abnormal meiosis 0.42274785918839 0.680494616484822 0.868566176470588 0.3125 25.1 25 1 increased intestinal adenocarcinoma incidence 0.42274785918839 0.680494616484822 0.868566176470588 0.3125 25.1 25 1 paternal imprinting 0.42274785918839 0.680494616484822 0.868566176470588 0.3125 25.1 25 1 decreased cochlear coiling 0.42274785918839 0.680494616484822 0.868566176470588 0.3125 25.1 25 1 impaired muscle relaxation 0.42274785918839 0.680494616484822 0.868566176470588 0.3125 25.1 25 1 large intestinal inflammation 0.42274785918839 0.680494616484822 0.868566176470588 0.3125 25.1 25 1 abnormal epididymis epithelium morphology 0.42274785918839 0.680494616484822 0.868566176470588 0.3125 25.1 25 1 abnormal wound healing 0.42274785918839 0.680494616484822 0.868566176470588 0.3125 25.1 25 1 decreased circulating prolactin level 0.42274785918839 0.680494616484822 0.868566176470588 0.3125 25.1 25 1 abnormal Langerhans cell physiology 0.42274785918839 0.680494616484822 0.868566176470588 0.3125 25.1 25 1 decreased midbrain size 0.42274785918839 0.680494616484822 0.868566176470588 0.3125 25.1 25 1 abnormal male meiosis 0.242785484216385 0.501081999410492 0.865718418514947 0.311475409836066 25.1 25 1 abnormal ectoderm development 0.28873366072138 0.513751774709895 0.864705882352941 0.311111111111111 25.1 25 1 increased autoantibody level 0.325788088110506 0.574408982712019 0.855203619909502 0.307692307692308 25.1 25 1 abnormal erythrocyte osmotic lysis 0.379112958868967 0.646584494471413 0.855203619909502 0.307692307692308 25.1 25 1 organ of Corti degeneration 0.302903279150967 0.536660902341903 0.850840336134454 0.306122448979592 25.1 25 1 abnormal retinal cone cell morphology 0.408469398715863 0.672002400334463 0.845907928388747 0.304347826086957 25.1 25 1 abnormal innervation pattern to muscle 0.408469398715863 0.672002400334463 0.845907928388747 0.304347826086957 25.1 25 1 head tossing 0.370302140643705 0.632207669767478 0.842245989304813 0.303030303030303 25.1 25 1 cardiovascular system phenotype 0.370302140643705 0.632207669767478 0.842245989304813 0.303030303030303 25.1 25 1 abnormal intestinal mucosa morphology 0.340597017016813 0.595595838192846 0.840287277701778 0.302325581395349 25.1 25 1 increased susceptibility to weight loss 0.36194681678556 0.619316962662719 0.833823529411765 0.3 25.1 25 1 abnormal thymocyte activation 0.442235153262371 0.680494616484822 0.833823529411765 0.3 25.1 25 1 abnormal optic stalk morphology 0.442235153262371 0.680494616484822 0.833823529411765 0.3 25.1 25 1 abnormal circulating cytokine level 0.442235153262371 0.680494616484822 0.833823529411765 0.3 25.1 25 1 abnormal heart tube morphology 0.396185717770523 0.655338551538649 0.833823529411765 0.3 25.1 25 1 abnormal synaptic transmission 0.396185717770523 0.655338551538649 0.833823529411765 0.3 25.1 25 1 decreased pancreatic beta cell number 0.410933685478012 0.675833086034085 0.817474048442907 0.294117647058824 25.1 25 1 abnormal heart rate 0.481822737094465 0.710874293311081 0.817474048442907 0.294117647058824 25.1 25 1 abnormal touch/ nociception 0.481822737094465 0.710874293311081 0.817474048442907 0.294117647058824 25.1 25 1 abnormal involuntary movement 0.481822737094465 0.710874293311081 0.817474048442907 0.294117647058824 25.1 25 1 abnormal spermiogenesis 0.357963100262917 0.614136321738788 0.814655172413793 0.293103448275862 25.1 25 1 abnormal cholesterol homeostasis 0.398626747851889 0.656243570669474 0.813486370157819 0.292682926829268 25.1 25 1 increased susceptibility to pharmacologically induced seizures 0.308569741860453 0.546505683786313 0.810661764705882 0.291666666666667 25.1 25 1 abnormal startle reflex 0.457816467792586 0.680494616484822 0.810661764705882 0.291666666666667 25.1 25 1 prolonged QT interval 0.457816467792586 0.680494616484822 0.810661764705882 0.291666666666667 25.1 25 1 abnormal cellular extravasation 0.457816467792586 0.680494616484822 0.810661764705882 0.291666666666667 25.1 25 1 impaired swimming 0.378515950119039 0.645787672099527 0.800133689839572 0.287878787878788 25.1 25 1 dehydration 0.387857057881564 0.655338551538649 0.794117647058824 0.285714285714286 25.1 25 1 increased incidence of induced tumors 0.495197054370903 0.724865778974115 0.794117647058824 0.285714285714286 25.1 25 1 enhanced coordination 0.470814923427825 0.695665056148925 0.794117647058823 0.285714285714286 25.1 25 1 deafness 0.376803046351932 0.64308581667268 0.786096256684492 0.282828282828283 25.1 25 1 abnormal inner ear morphology 0.445959452888398 0.680494616484822 0.785485933503836 0.282608695652174 25.1 25 1 circling 0.394947810182824 0.655338551538649 0.78477508650519 0.282352941176471 25.1 25 1 abnormal leukocyte adhesion 0.462457192533729 0.685147270058161 0.78393665158371 0.282051282051282 25.1 25 1 abnormal crypts of Lieberkuhn morphology 0.481987912593743 0.710907164291097 0.781709558823529 0.28125 25.1 25 1 abnormal thyroid gland morphology 0.506204738359029 0.732936138922052 0.778235294117647 0.28 25.1 25 1 increased pre-B cell number 0.506204738359029 0.732936138922052 0.778235294117647 0.28 25.1 25 1 abnormal male reproductive system morphology 0.472228209767829 0.697546123395175 0.775649794801642 0.27906976744186 25.1 25 1 head tilt 0.491806400507472 0.724865778974115 0.772058823529412 0.277777777777778 25.1 25 1 cortical renal glomerulopathies 0.538635488813353 0.772028682468001 0.772058823529412 0.277777777777778 25.1 25 1 abnormal iron level 0.538635488813353 0.772028682468001 0.772058823529412 0.277777777777778 25.1 25 1 abnormal sperm axoneme morphology 0.538635488813353 0.772028682468001 0.772058823529412 0.277777777777778 25.1 25 1 small thoracic cage 0.538635488813353 0.772028682468001 0.772058823529412 0.277777777777778 25.1 25 1 impaired leukocyte tethering or rolling 0.538635488813353 0.772028682468001 0.772058823529412 0.277777777777778 25.1 25 1 cochlear ganglion degeneration 0.472424389204802 0.697628773016886 0.766734279918864 0.275862068965517 25.1 25 1 enlarged epididymis 0.515613296337848 0.745108853322323 0.766734279918864 0.275862068965517 25.1 25 1 diarrhea 0.523870077075007 0.753688153108201 0.758021390374332 0.272727272727273 25.1 25 1 increased activated T cell number 0.54631804788018 0.782589199022141 0.758021390374332 0.272727272727273 25.1 25 1 parakeratosis 0.54631804788018 0.782589199022141 0.758021390374332 0.272727272727273 25.1 25 1 abnormal hair shaft morphology 0.515806894103243 0.745108853322323 0.752757352941177 0.270833333333333 25.1 25 1 abnormal response to novelty 0.592353893802753 0.808517734276797 0.731424148606811 0.263157894736842 25.1 25 1 abnormal behavioral response to xenobiotic 0.592353893802753 0.808517734276797 0.731424148606811 0.263157894736842 25.1 25 1 bidirectional circling 0.594970512291115 0.808517734276797 0.725063938618926 0.260869565217391 25.1 25 1 hypotension 0.594970512291115 0.808517734276797 0.725063938618926 0.260869565217391 25.1 25 1 abnormal cochlear ganglion morphology 0.594970512291115 0.808517734276797 0.725063938618926 0.260869565217391 25.1 25 1 abnormal regulatory T cell physiology 0.594970512291115 0.808517734276797 0.725063938618926 0.260869565217391 25.1 25 1 abnormal palatal shelf fusion at midline 0.594970512291115 0.808517734276797 0.725063938618926 0.260869565217391 25.1 25 1 abnormal hepatocyte physiology 0.594970512291115 0.808517734276797 0.725063938618926 0.260869565217391 25.1 25 1 abnormal digestive system physiology 0.582980481943219 0.808517734276797 0.722647058823529 0.26 25.1 25 1 wrinkled skin 0.597792762219061 0.808517734276797 0.720588235294118 0.259259259259259 25.1 25 1 decreased susceptibility to pharmacologically induced seizures 0.597792762219061 0.808517734276797 0.720588235294118 0.259259259259259 25.1 25 1 abnormal intestine physiology 0.600699190353473 0.808517734276797 0.717267552182163 0.258064516129032 25.1 25 1 cochlear inner hair cell degeneration 0.615050821066979 0.825432380579504 0.708477508650519 0.254901960784314 25.1 25 1 increased stereotypic behavior 0.640688527123958 0.858450154172284 0.694852941176471 0.25 25.1 25 1 apnea 0.640688527123958 0.858450154172284 0.694852941176471 0.25 25.1 25 1 abnormal sensory capabilities/reflexes/nociception 0.640688527123958 0.858450154172284 0.694852941176471 0.25 25.1 25 1 abnormal male reproductive system physiology 0.64239347398288 0.860271206746925 0.694852941176471 0.25 25.1 25 1 decreased circulating VLDL cholesterol level 0.64239347398288 0.860271206746925 0.694852941176471 0.25 25.1 25 1 abnormal stria vascularis morphology 0.640118708482806 0.858380208814544 0.694852941176471 0.25 25.1 25 1 reddish skin 0.640118708482806 0.858380208814544 0.694852941176471 0.25 25.1 25 1 increased circulating luteinizing hormone level 0.640118708482806 0.858380208814544 0.694852941176471 0.25 25.1 25 1 abnormal inhibitory postsynaptic currents 0.652473859127041 0.871447141901052 0.694852941176471 0.25 25.1 25 1 absent vibrissae 0.677517468816863 0.894546021062605 0.67379679144385 0.242424242424242 25.1 25 1 decreased retinal photoreceptor cell number 0.679734066892565 0.897234540406079 0.670892494929006 0.241379310344828 25.1 25 1 impaired conditioned place preference behavior 0.683157091997094 0.901513669147358 0.667058823529412 0.24 25.1 25 1 cochlear outer hair cell degeneration 0.748697689388769 0.950439143840042 0.65625 0.236111111111111 25.1 25 1 gastrointestinal hemorrhage 0.716466585204138 0.91653928037814 0.648529411764706 0.233333333333333 25.1 25 1 abnormal response to new environment 0.716466585204138 0.91653928037814 0.648529411764706 0.233333333333333 25.1 25 1 decreased airway responsiveness 0.730178916062047 0.931249792626066 0.63168449197861 0.227272727272727 25.1 25 1 abnormal gametogenesis 0.763993733397243 0.969114947386865 0.63168449197861 0.227272727272727 25.1 25 1 scaly skin 0.794695489415315 0.988649677379643 0.610114777618364 0.219512195121951 25.1 25 1 stomach inflammation 0.818535483634013 1 0.575050709939148 0.206896551724138 25.1 25 1 impaired fertilization 0.91684845939571 1 0.555882352941176 0.2 25.1 25 1 abnormal feces composition 0.830673931496925 1 0.555882352941176 0.2 25.1 25 1 abnormal body temperature homeostasis 0.866569660130897 1 0.537950664136622 0.193548387096774 25.1 25 1 autoimmune response 0.866569660130897 1 0.537950664136622 0.193548387096774 25.1 25 1 abnormal tectorial membrane morphology 0.856502055202301 1 0.534502262443439 0.192307692307692 25.1 25 1 abnormal reflex 0.942309297572607 1 0.463235294117647 0.166666666666667 25.1 25 1 decreased susceptibility to parasitic infection 0.95131199906823 1 0.434283088235294 0.15625 25.1 25 1 decreased liver function 2.27372564462797e-05 0.000646387718972808 4.9390756302521 1 25.2 25 2 abnormal mammary gland bud morphology 0.000135136674505232 0.00259634698290432 4.9390756302521 1 25.2 25 2 aorta coarctation 0.000136210364329252 0.00259634698290432 4.23349339735894 0.857142857142857 25.2 25 2 decreased tidal volume 0.000136210364329252 0.00259634698290432 4.23349339735894 0.857142857142857 25.2 25 2 abnormal aorta tunica adventitia morphology 0.000697133764799994 0.00942456652141296 4.11589635854342 0.833333333333333 25.2 25 2 abnormal olfactory bulb layer morphology 0.000697133764799994 0.00942456652141296 4.11589635854342 0.833333333333333 25.2 25 2 thick pulmonary valve cusps 0.000697133764799994 0.00942456652141296 4.11589635854342 0.833333333333333 25.2 25 2 abnormal primordial germ cell migration 2.09513148429269e-05 0.000602501684066828 3.95126050420168 0.8 25.2 25 2 abnormal hepatobiliary system morphology 0.000466551033100159 0.00684687725567342 3.70430672268908 0.75 25.2 25 2 abnormal canal of Schlemm morphology 0.000466551033100159 0.00684687725567342 3.70430672268908 0.75 25.2 25 2 skin fibrosis 0.000466551033100159 0.00684687725567342 3.70430672268908 0.75 25.2 25 2 abnormal olfactory bulb mitral cell layer morphology 0.000466551033100159 0.00684687725567342 3.70430672268908 0.75 25.2 25 2 decreased vascular endothelial cell proliferation 0.000466551033100159 0.00684687725567342 3.70430672268908 0.75 25.2 25 2 abnormal sphenoid bone morphology 6.53877318197418e-05 0.00142054133538522 3.59205500381971 0.727272727272727 25.2 25 2 abnormal aorta smooth muscle morphology 6.53877318197418e-05 0.00142054133538522 3.59205500381971 0.727272727272727 25.2 25 2 increased cell nucleus count 0.00209944226597685 0.0221286552399043 3.52791116446579 0.714285714285714 25.2 25 2 skeletal muscle interstitial fibrosis 0.00209944226597685 0.0221286552399043 3.52791116446579 0.714285714285714 25.2 25 2 increased susceptibility to atherosclerosis 0.00028510848317802 0.00468894075192882 3.45735294117647 0.7 25.2 25 2 abnormal heart and great artery attachment 0.00028510848317802 0.00468894075192882 3.45735294117647 0.7 25.2 25 2 abnormal lymph node B cell domain morphology 2.39065189517245e-05 0.000660749621026829 3.29271708683473 0.666666666666667 25.2 25 2 delayed intramembranous bone ossification 2.39065189517245e-05 0.000660749621026829 3.29271708683473 0.666666666666667 25.2 25 2 abnormal olfactory nerve morphology 2.39065189517245e-05 0.000660749621026829 3.29271708683473 0.666666666666667 25.2 25 2 abnormal vitelline vein connection 0.000167034414150181 0.00307776374221167 3.29271708683473 0.666666666666667 25.2 25 2 abnormal posterior semicircular canal morphology 0.00119925616861357 0.014446245614655 3.29271708683473 0.666666666666667 25.2 25 2 abnormal posterior eye segment morphology 0.00119925616861357 0.014446245614655 3.29271708683473 0.666666666666667 25.2 25 2 increased myeloid cell number 0.00119925616861357 0.014446245614655 3.29271708683473 0.666666666666667 25.2 25 2 vascular smooth muscle hypoplasia 9.56744227593872e-05 0.00196686055052873 3.17512004801921 0.642857142857143 25.2 25 2 decreased atrioventricular cushion size 0.000669619798055003 0.00912700957622915 3.14304812834225 0.636363636363636 25.2 25 2 abnormal bronchiole morphology 0.000669619798055003 0.00912700957622915 3.14304812834225 0.636363636363636 25.2 25 2 common atrioventricular valve 0.000669619798055003 0.00912700957622915 3.14304812834225 0.636363636363636 25.2 25 2 abnormal ear pigmentation 0.00482092765410467 0.039828792403837 3.08692226890756 0.625 25.2 25 2 abnormal exoccipital bone morphology 0.00482092765410467 0.039828792403837 3.08692226890756 0.625 25.2 25 2 head spot 0.00482092765410467 0.039828792403837 3.08692226890756 0.625 25.2 25 2 absent tympanic ring 0.00482092765410467 0.039828792403837 3.08692226890756 0.625 25.2 25 2 abnormal umbilical artery morphology 0.00482092765410467 0.039828792403837 3.08692226890756 0.625 25.2 25 2 binucleate 0.00482092765410467 0.039828792403837 3.08692226890756 0.625 25.2 25 2 accumulation of giant lysosomes in kidney/renal tubule cells 0.00482092765410467 0.039828792403837 3.08692226890756 0.625 25.2 25 2 increased aorta wall thickness 0.00482092765410467 0.039828792403837 3.08692226890756 0.625 25.2 25 2 empty decidua capsularis 0.000369953707510197 0.00578779778258877 3.03943115707822 0.615384615384615 25.2 25 2 lowered ear position 3.03224393103837e-05 0.00078981222811078 3.01832399626517 0.611111111111111 25.2 25 2 abnormal artery morphology 1.1098958143148e-08 9.05201914133794e-07 2.96344537815126 0.6 25.2 25 2 abnormal pericyte morphology 0.000203326278470882 0.00362562091538579 2.96344537815126 0.6 25.2 25 2 jaundice 0.00257047769676689 0.0255252026774756 2.96344537815126 0.6 25.2 25 2 fused cornea and lens 0.00257047769676689 0.0255252026774756 2.96344537815126 0.6 25.2 25 2 abnormal airway responsiveness 0.00257047769676689 0.0255252026774756 2.96344537815126 0.6 25.2 25 2 decreased transitional stage T2 B cell number 0.00257047769676689 0.0255252026774756 2.96344537815126 0.6 25.2 25 2 abnormal left subclavian artery morphology 0.00257047769676689 0.0255252026774756 2.96344537815126 0.6 25.2 25 2 thin ventricle myocardium compact layer 0.00257047769676689 0.0255252026774756 2.96344537815126 0.6 25.2 25 2 thick aortic valve 0.00257047769676689 0.0255252026774756 2.96344537815126 0.6 25.2 25 2 decreased macrophage cytokine production 0.00257047769676689 0.0255252026774756 2.96344537815126 0.6 25.2 25 2 abnormal vascular branching morphogenesis 9.3989362171184e-06 0.000309362443504682 2.91854469060351 0.590909090909091 25.2 25 2 abnormal limb posture 9.3989362171184e-06 0.000309362443504682 2.91854469060351 0.590909090909091 25.2 25 2 hydroureter 0.000111456943847189 0.00221799318255905 2.90533860603065 0.588235294117647 25.2 25 2 abnormal supraoccipital bone morphology 0.00137323933552176 0.0158511965063127 2.88112745098039 0.583333333333333 25.2 25 2 absent optic nerve 0.00137323933552176 0.0158511965063127 2.88112745098039 0.583333333333333 25.2 25 2 increased papilloma incidence 0.00137323933552176 0.0158511965063127 2.88112745098039 0.583333333333333 25.2 25 2 abnormal aorta elastic fiber morphology 0.00137323933552176 0.0158511965063127 2.88112745098039 0.583333333333333 25.2 25 2 abnormal palatine bone morphology 0.00137323933552176 0.0158511965063127 2.88112745098039 0.583333333333333 25.2 25 2 decreased mammary gland epithelial cell proliferation 0.00137323933552176 0.0158511965063127 2.88112745098039 0.583333333333333 25.2 25 2 ventricular hypoplasia 2.88474875710652e-06 0.000113004921784291 2.84946670976083 0.576923076923077 25.2 25 2 abnormal vasoconstriction 0.000735659420511276 0.00978584389583849 2.82232893157263 0.571428571428571 25.2 25 2 irregularly shaped pupil 0.000735659420511276 0.00978584389583849 2.82232893157263 0.571428571428571 25.2 25 2 vasculature congestion 0.000395211381174234 0.00591961821119974 2.77823004201681 0.5625 25.2 25 2 abnormal hair follicle orientation 0.000395211381174234 0.00591961821119974 2.77823004201681 0.5625 25.2 25 2 white spotting 0.000395211381174234 0.00591961821119974 2.77823004201681 0.5625 25.2 25 2 abnormal epicardium morphology 0.000395211381174234 0.00591961821119974 2.77823004201681 0.5625 25.2 25 2 decreased fibroblast apoptosis 0.000395211381174234 0.00591961821119974 2.77823004201681 0.5625 25.2 25 2 decreased adipocyte glucose uptake 0.000395211381174234 0.00591961821119974 2.77823004201681 0.5625 25.2 25 2 hydrops fetalis 9.61987663455085e-14 2.39294431284452e-11 2.74393090569561 0.555555555555556 25.2 25 2 abnormal mitral valve morphology 0.000212875074518194 0.00372511369087477 2.74393090569561 0.555555555555556 25.2 25 2 abnormal bile duct morphology 0.000212875074518194 0.00372511369087477 2.74393090569561 0.555555555555556 25.2 25 2 long tibia 0.000212875074518194 0.00372511369087477 2.74393090569561 0.555555555555556 25.2 25 2 distorted hair follicle pattern 0.00934801701096855 0.0637102341855027 2.74393090569561 0.555555555555556 25.2 25 2 decreased level of surface class I molecules 0.00934801701096855 0.0637102341855027 2.74393090569561 0.555555555555556 25.2 25 2 abnormal germ cell morphology 0.00934801701096855 0.0637102341855027 2.74393090569561 0.555555555555556 25.2 25 2 abnormal thymus physiology 0.00934801701096855 0.0637102341855027 2.74393090569561 0.555555555555556 25.2 25 2 decreased cellular sensitivity to ionizing radiation 0.00934801701096855 0.0637102341855027 2.74393090569561 0.555555555555556 25.2 25 2 abnormal stria vascularis vasculature morphology 0.00934801701096855 0.0637102341855027 2.74393090569561 0.555555555555556 25.2 25 2 abnormal intervertebral disk development 0.00934801701096855 0.0637102341855027 2.74393090569561 0.555555555555556 25.2 25 2 eye opacity 0.00934801701096855 0.0637102341855027 2.74393090569561 0.555555555555556 25.2 25 2 prolonged RR interval 0.00934801701096855 0.0637102341855027 2.74393090569561 0.555555555555556 25.2 25 2 iris coloboma 0.00934801701096855 0.0637102341855027 2.74393090569561 0.555555555555556 25.2 25 2 abnormal ductus venosus valve topology 0.00934801701096855 0.0637102341855027 2.74393090569561 0.555555555555556 25.2 25 2 increased cardiac muscle glycogen level 0.00934801701096855 0.0637102341855027 2.74393090569561 0.555555555555556 25.2 25 2 cerebellum atrophy 0.00934801701096855 0.0637102341855027 2.74393090569561 0.555555555555556 25.2 25 2 adipose tissue inflammation 0.00934801701096855 0.0637102341855027 2.74393090569561 0.555555555555556 25.2 25 2 increased mammary adenocarcinoma incidence 0.000114935877734212 0.00227811152082751 2.71649159663865 0.55 25.2 25 2 belly spot 9.01705497926312e-07 4.27236652588896e-05 2.69404125286478 0.545454545454545 25.2 25 2 increased skin papilloma incidence 6.21889931070837e-05 0.00139995584030652 2.69404125286478 0.545454545454545 25.2 25 2 abnormal ear position 0.00485150717522115 0.039828792403837 2.69404125286478 0.545454545454545 25.2 25 2 premature suture closure 0.00485150717522115 0.039828792403837 2.69404125286478 0.545454545454545 25.2 25 2 increased mast cell number 0.00485150717522115 0.039828792403837 2.69404125286478 0.545454545454545 25.2 25 2 enlarged cranium 0.00485150717522115 0.039828792403837 2.69404125286478 0.545454545454545 25.2 25 2 delayed hepatic development 0.00485150717522115 0.039828792403837 2.69404125286478 0.545454545454545 25.2 25 2 abnormal eye distance/ position 0.00485150717522115 0.039828792403837 2.69404125286478 0.545454545454545 25.2 25 2 retinal detachment 0.00485150717522115 0.039828792403837 2.69404125286478 0.545454545454545 25.2 25 2 loss of cortex neurons 0.00485150717522115 0.039828792403837 2.69404125286478 0.545454545454545 25.2 25 2 abnormal radial glial cell morphology 0.00485150717522115 0.039828792403837 2.69404125286478 0.545454545454545 25.2 25 2 abnormal dorsal-ventral polarity of the somites 0.00485150717522115 0.039828792403837 2.69404125286478 0.545454545454545 25.2 25 2 abnormal Bruch membrane morphology 0.00485150717522115 0.039828792403837 2.69404125286478 0.545454545454545 25.2 25 2 palatal shelf hypoplasia 0.00485150717522115 0.039828792403837 2.69404125286478 0.545454545454545 25.2 25 2 abnormal aorta tunica media morphology 0.00254373923486858 0.0255252026774756 2.65950226244344 0.538461538461538 25.2 25 2 trabecula carnea hypoplasia 2.47517815054618e-08 1.92406426546363e-06 2.63417366946779 0.533333333333333 25.2 25 2 heterochrony 0.00134404015427173 0.0157539409390966 2.63417366946779 0.533333333333333 25.2 25 2 abnormal bone marrow cavity morphology 0.000714435123167162 0.0096062560479909 2.61480474542758 0.529411764705882 25.2 25 2 abnormal cranial suture morphology 0.000714435123167162 0.0096062560479909 2.61480474542758 0.529411764705882 25.2 25 2 increased liver cholesterol level 0.000381600194405239 0.00589584151293809 2.59951348960637 0.526315789473684 25.2 25 2 embryonic lethality between implantation and somite formation, incomplete penetrance 0.000381600194405239 0.00589584151293809 2.59951348960637 0.526315789473684 25.2 25 2 increased muscle cell glucose uptake 0.000204631484958032 0.00363586299166503 2.58713485394158 0.523809523809524 25.2 25 2 abnormal fetal cardiomyocyte proliferation 3.21241363597119e-05 0.000828070354350086 2.56100217864924 0.518518518518518 25.2 25 2 decreased trophoblast giant cell number 1.74093243874531e-05 0.000515144419126965 2.55469429150971 0.517241379310345 25.2 25 2 osteopetrosis 9.4518776708968e-06 0.000309362443504682 2.54920032529141 0.516129032258065 25.2 25 2 increased carcinoma incidence 2.79888657677776e-06 0.000110511593011662 2.54009603841537 0.514285714285714 25.2 25 2 decreased bone volume 2.79888657677776e-06 0.000110511593011662 2.54009603841537 0.514285714285714 25.2 25 2 abnormal ureter morphology 0.000100491294515884 0.00205556907619612 2.46953781512605 0.5 25.2 25 2 abnormal olfaction 0.00229286892736921 0.0236170246659665 2.46953781512605 0.5 25.2 25 2 increased pancreatic beta cell number 0.00229286892736921 0.0236170246659665 2.46953781512605 0.5 25.2 25 2 decreased liver cholesterol level 0.00229286892736921 0.0236170246659665 2.46953781512605 0.5 25.2 25 2 abnormal pulmonary alveolus wall morphology 0.00229286892736921 0.0236170246659665 2.46953781512605 0.5 25.2 25 2 embryonic lethality between somite formation and embryo turning, incomplete penetrance 0.00229286892736921 0.0236170246659665 2.46953781512605 0.5 25.2 25 2 abnormal esophagus morphology 0.00832977501492053 0.0602334748535315 2.46953781512605 0.5 25.2 25 2 abnormal tracheal ciliated epithelium morphology 0.00832977501492053 0.0602334748535315 2.46953781512605 0.5 25.2 25 2 dilated bile duct 0.00832977501492053 0.0602334748535315 2.46953781512605 0.5 25.2 25 2 hematuria 0.00832977501492053 0.0602334748535315 2.46953781512605 0.5 25.2 25 2 abnormal aorta elastic tissue morphology 0.00832977501492053 0.0602334748535315 2.46953781512605 0.5 25.2 25 2 decreased red blood cell distribution width 0.00832977501492053 0.0602334748535315 2.46953781512605 0.5 25.2 25 2 abnormal hormone level 5.42918370980091e-05 0.00123334196147304 2.46953781512605 0.5 25.2 25 2 subcutaneous edema 5.42918370980091e-05 0.00123334196147304 2.46953781512605 0.5 25.2 25 2 abnormal basement membrane morphology 0.000347073976808981 0.0055487088626885 2.46953781512605 0.5 25.2 25 2 abnormal pericardium morphology 0.000648264511076264 0.00895865539612338 2.46953781512605 0.5 25.2 25 2 abnormal physiological neovascularization 0.000648264511076264 0.00895865539612338 2.46953781512605 0.5 25.2 25 2 absent ductus venosus valve 0.000648264511076264 0.00895865539612338 2.46953781512605 0.5 25.2 25 2 decreased muscle cell glucose uptake 0.000648264511076264 0.00895865539612338 2.46953781512605 0.5 25.2 25 2 delayed kidney development 0.00121599517181613 0.0145073764503243 2.46953781512605 0.5 25.2 25 2 abnormal thymus cortex morphology 0.00121599517181613 0.0145073764503243 2.46953781512605 0.5 25.2 25 2 abnormal metacarpal bone morphology 0.00121599517181613 0.0145073764503243 2.46953781512605 0.5 25.2 25 2 increased gastrointestinal tumor incidence 0.00121599517181613 0.0145073764503243 2.46953781512605 0.5 25.2 25 2 abnormal interparietal bone morphology 0.00435181904922589 0.0381839502114618 2.46953781512605 0.5 25.2 25 2 increased aggression towards males 0.00435181904922589 0.0381839502114618 2.46953781512605 0.5 25.2 25 2 increased hemangioma incidence 0.00435181904922589 0.0381839502114618 2.46953781512605 0.5 25.2 25 2 amyloid beta deposits 0.00435181904922589 0.0381839502114618 2.46953781512605 0.5 25.2 25 2 abnormal vascular endothelial cell migration 0.00435181904922589 0.0381839502114618 2.46953781512605 0.5 25.2 25 2 abnormal maternal decidual layer morphology 0.00435181904922589 0.0381839502114618 2.46953781512605 0.5 25.2 25 2 abnormal viscerocranium morphology 0.00435181904922589 0.0381839502114618 2.46953781512605 0.5 25.2 25 2 abnormal glucose tolerance 0.00435181904922589 0.0381839502114618 2.46953781512605 0.5 25.2 25 2 spina bifida occulta 0.00435181904922589 0.0381839502114618 2.46953781512605 0.5 25.2 25 2 increased stomach tumor incidence 0.00435181904922589 0.0381839502114618 2.46953781512605 0.5 25.2 25 2 testis degeneration 0.00435181904922589 0.0381839502114618 2.46953781512605 0.5 25.2 25 2 increased cranium width 0.0161255563251702 0.0957664941232414 2.46953781512605 0.5 25.2 25 2 enlarged testis 0.0161255563251702 0.0957664941232414 2.46953781512605 0.5 25.2 25 2 abnormal immune cell physiology 0.0161255563251702 0.0957664941232414 2.46953781512605 0.5 25.2 25 2 abnormal PNS synaptic transmission 0.0161255563251702 0.0957664941232414 2.46953781512605 0.5 25.2 25 2 primary sex reversal 0.0161255563251702 0.0957664941232414 2.46953781512605 0.5 25.2 25 2 aneurysm 0.0161255563251702 0.0957664941232414 2.46953781512605 0.5 25.2 25 2 bifid ureter 0.0161255563251702 0.0957664941232414 2.46953781512605 0.5 25.2 25 2 abnormal deltoid tuberosity morphology 0.0161255563251702 0.0957664941232414 2.46953781512605 0.5 25.2 25 2 abnormal gonadal fat pad morphology 0.0161255563251702 0.0957664941232414 2.46953781512605 0.5 25.2 25 2 osteosclerosis 0.0161255563251702 0.0957664941232414 2.46953781512605 0.5 25.2 25 2 abnormal spinal cord dorsal column morphology 0.0161255563251702 0.0957664941232414 2.46953781512605 0.5 25.2 25 2 protruding tongue 0.0161255563251702 0.0957664941232414 2.46953781512605 0.5 25.2 25 2 abnormal retinal blood vessel pattern 0.0161255563251702 0.0957664941232414 2.46953781512605 0.5 25.2 25 2 abnormal inferior vena cava valve morphology 0.0161255563251702 0.0957664941232414 2.46953781512605 0.5 25.2 25 2 thick aortic valve cusps 0.0161255563251702 0.0957664941232414 2.46953781512605 0.5 25.2 25 2 abnormal pulmonary interalveolar septum morphology 0.0161255563251702 0.0957664941232414 2.46953781512605 0.5 25.2 25 2 decreased circulating lactate level 0.0161255563251702 0.0957664941232414 2.46953781512605 0.5 25.2 25 2 perimembraneous ventricular septal defect 5.17984575098439e-10 7.57933312092569e-08 2.43374741200828 0.492753623188406 25.2 25 2 thick pulmonary interalveolar septum 1.42066109802018e-05 0.000436283269299408 2.39897959183673 0.485714285714286 25.2 25 2 abnormal aorta morphology 2.61189166125053e-05 0.000710063443427397 2.39470333587981 0.484848484848485 25.2 25 2 enlarged pericardium 2.61189166125053e-05 0.000710063443427397 2.39470333587981 0.484848484848485 25.2 25 2 abnormal capillary morphology 4.80944325435017e-05 0.00113938000906629 2.38987530496069 0.483870967741935 25.2 25 2 abnormal outer ear morphology 8.87155156278612e-05 0.00184669326463853 2.38438133874239 0.482758620689655 25.2 25 2 abnormal heart valve morphology 0.000163975084232331 0.00304394046289496 2.37807345160286 0.481481481481481 25.2 25 2 overriding aortic valve 6.08435293614333e-07 3.15308915180344e-05 2.36664040616246 0.479166666666667 25.2 25 2 failure to gastrulate 1.10996671484917e-06 5.1551359589133e-05 2.36216660577274 0.478260869565217 25.2 25 2 abnormal circulating insulin level 0.00056430416892928 0.00797560579665672 2.36216660577274 0.478260869565217 25.2 25 2 abnormal Wolffian duct morphology 0.00056430416892928 0.00797560579665672 2.36216660577274 0.478260869565217 25.2 25 2 abnormal hematopoietic system physiology 0.00105156726209284 0.0129815065233546 2.35194077631052 0.476190476190476 25.2 25 2 abnormal tumor vascularization 0.00105156726209284 0.0129815065233546 2.35194077631052 0.476190476190476 25.2 25 2 vascular ring 0.00105156726209284 0.0129815065233546 2.35194077631052 0.476190476190476 25.2 25 2 lethality throughout fetal growth and development, complete penetrance 1.43511348468274e-22 8.92461198287081e-20 2.33956214064573 0.473684210526316 25.2 25 2 kyphoscoliosis 0.00196695065148593 0.0210071015614824 2.33956214064573 0.473684210526316 25.2 25 2 decreased tumor incidence 0.00196695065148593 0.0210071015614824 2.33956214064573 0.473684210526316 25.2 25 2 increased circulating VLDL cholesterol level 0.00196695065148593 0.0210071015614824 2.33956214064573 0.473684210526316 25.2 25 2 decreased circulating total protein level 1.60192524423207e-07 9.60190131331872e-06 2.33483575248281 0.472727272727273 25.2 25 2 abnormal pharyngeal arch morphology 2.269826483328e-05 0.000646387718972808 2.33234126984127 0.472222222222222 25.2 25 2 enlarged liver sinusoidal spaces 4.16328724725392e-05 0.00101531147328864 2.32427088482452 0.470588235294118 25.2 25 2 abnormal adipose tissue morphology 0.00369592119777104 0.0340503851090943 2.32427088482452 0.470588235294118 25.2 25 2 abnormal ectoplacental cone morphology 0.00369592119777104 0.0340503851090943 2.32427088482452 0.470588235294118 25.2 25 2 abnormal heart atrium morphology 7.64596201456957e-05 0.00162558380437964 2.31519170168067 0.46875 25.2 25 2 abnormal neurocranium morphology 1.87139085768002e-09 2.11594761749048e-07 2.30490196078431 0.466666666666667 25.2 25 2 abnormal microglial cell physiology 0.000140619722446125 0.00265314421684362 2.30490196078431 0.466666666666667 25.2 25 2 abnormal placenta size 0.00698362558231078 0.0528017283768938 2.30490196078431 0.466666666666667 25.2 25 2 decreased thymocyte apoptosis 0.00698362558231078 0.0528017283768938 2.30490196078431 0.466666666666667 25.2 25 2 abnormal secondary palate development 0.00698362558231078 0.0528017283768938 2.30490196078431 0.466666666666667 25.2 25 2 abnormal aorta wall morphology 0.00698362558231078 0.0528017283768938 2.30490196078431 0.466666666666667 25.2 25 2 abnormal coronary vessel morphology 0.00698362558231078 0.0528017283768938 2.30490196078431 0.466666666666667 25.2 25 2 delayed endochondral bone ossification 5.82645040773871e-06 0.000201295769295139 2.29724447918702 0.465116279069767 25.2 25 2 shortened head 0.000259033898415411 0.00435369474532659 2.29314225690276 0.464285714285714 25.2 25 2 abnormal ovulation 0.000259033898415411 0.00435369474532659 2.29314225690276 0.464285714285714 25.2 25 2 hypoxia 0.000259033898415411 0.00435369474532659 2.29314225690276 0.464285714285714 25.2 25 2 abnormal mammary gland development 1.06258148240559e-05 0.000345512606207046 2.28883992621439 0.463414634146341 25.2 25 2 decreased tumor growth/size 4.55617294573514e-07 2.49087476978377e-05 2.28660908807968 0.462962962962963 25.2 25 2 liver hypoplasia 8.2681222078994e-07 4.0372406795934e-05 2.27957336780866 0.461538461538462 25.2 25 2 abnormal xiphoid process morphology 0.000478030505710287 0.00698736436198501 2.27957336780866 0.461538461538462 25.2 25 2 short premaxilla 0.0132892342549651 0.083900939617324 2.27957336780866 0.461538461538462 25.2 25 2 absent teeth 0.0132892342549651 0.083900939617324 2.27957336780866 0.461538461538462 25.2 25 2 absent common myeloid progenitor cells 0.0132892342549651 0.083900939617324 2.27957336780866 0.461538461538462 25.2 25 2 absent trabeculae carneae 0.0132892342549651 0.083900939617324 2.27957336780866 0.461538461538462 25.2 25 2 abnormal pulmonary alveolus epithelial cell morphology 0.0132892342549651 0.083900939617324 2.27957336780866 0.461538461538462 25.2 25 2 anal atresia 0.0132892342549651 0.083900939617324 2.27957336780866 0.461538461538462 25.2 25 2 increased cochlear inner hair cell number 0.0132892342549651 0.083900939617324 2.27957336780866 0.461538461538462 25.2 25 2 abnormal exocrine pancreas morphology 0.0132892342549651 0.083900939617324 2.27957336780866 0.461538461538462 25.2 25 2 abnormal vertebral arch development 0.0132892342549651 0.083900939617324 2.27957336780866 0.461538461538462 25.2 25 2 abnormal extraembryonic tissue morphology 5.90002557736209e-12 1.12894720182217e-09 2.27584857472401 0.46078431372549 25.2 25 2 abnormal interventricular septum morphology 1.50084162522315e-06 6.49277137868274e-05 2.27197478991597 0.46 25.2 25 2 abnormal angiogenesis 5.24802671621197e-09 4.81900728991069e-07 2.26930501930502 0.459459459459459 25.2 25 2 abnormal foregut morphology 0.000884003162626373 0.0113056959744633 2.26374299719888 0.458333333333333 25.2 25 2 lethality throughout fetal growth and development, incomplete penetrance 1.47646873657788e-19 6.12119330372913e-17 2.26259330547862 0.458100558659218 25.2 25 2 double outlet right ventricle 2.80828403649751e-12 5.58848523263005e-10 2.26181968114349 0.457943925233645 25.2 25 2 abnormal liver development 6.4728671623981e-05 0.00142054133538522 2.2578631452581 0.457142857142857 25.2 25 2 decreased glycogen level 6.4728671623981e-05 0.00142054133538522 2.2578631452581 0.457142857142857 25.2 25 2 abnormal tooth development 0.000118410206423354 0.00233313157323552 2.24503437738732 0.454545454545455 25.2 25 2 omphalocele 8.99321925750945e-06 0.000302305850041281 2.24503437738732 0.454545454545455 25.2 25 2 abnormal tail movements 0.0016386449998294 0.0181970064155162 2.24503437738732 0.454545454545455 25.2 25 2 abnormal germ layer development 0.0016386449998294 0.0181970064155162 2.24503437738732 0.454545454545455 25.2 25 2 abnormal tracheal cartilage morphology 0.0016386449998294 0.0181970064155162 2.24503437738732 0.454545454545455 25.2 25 2 cleft upper lip 0.0016386449998294 0.0181970064155162 2.24503437738732 0.454545454545455 25.2 25 2 failure of palatal shelf elevation 0.0016386449998294 0.0181970064155162 2.24503437738732 0.454545454545455 25.2 25 2 abnormal larynx morphology 0.0255205972834611 0.133226622754689 2.24503437738732 0.454545454545455 25.2 25 2 variable body spotting 0.0255205972834611 0.133226622754689 2.24503437738732 0.454545454545455 25.2 25 2 abnormal ureter development 0.0255205972834611 0.133226622754689 2.24503437738732 0.454545454545455 25.2 25 2 abnormal hair medulla 0.0255205972834611 0.133226622754689 2.24503437738732 0.454545454545455 25.2 25 2 abnormal coronal suture morphology 0.0255205972834611 0.133226622754689 2.24503437738732 0.454545454545455 25.2 25 2 increased glycogen level 0.0255205972834611 0.133226622754689 2.24503437738732 0.454545454545455 25.2 25 2 aberrant origin of the right subclavian artery 0.0255205972834611 0.133226622754689 2.24503437738732 0.454545454545455 25.2 25 2 aorta dilation 0.0255205972834611 0.133226622754689 2.24503437738732 0.454545454545455 25.2 25 2 increased subcutaneous adipose tissue amount 0.0255205972834611 0.133226622754689 2.24503437738732 0.454545454545455 25.2 25 2 reduced sympathetic cervical ganglion size 0.0255205972834611 0.133226622754689 2.24503437738732 0.454545454545455 25.2 25 2 small gonad 0.00304587567545748 0.0297705923092356 2.22258403361345 0.45 25.2 25 2 abnormal circulating enzyme level 0.00304587567545748 0.0297705923092356 2.22258403361345 0.45 25.2 25 2 anencephaly 0.00304587567545748 0.0297705923092356 2.22258403361345 0.45 25.2 25 2 abnormal neuron proliferation 0.00304587567545748 0.0297705923092356 2.22258403361345 0.45 25.2 25 2 abnormal microglial cell morphology 0.000397417584430294 0.00591961821119974 2.21406838597508 0.448275862068966 25.2 25 2 increased mortality induced by gamma-irradiation 0.000397417584430294 0.00591961821119974 2.21406838597508 0.448275862068966 25.2 25 2 abnormal erythropoiesis 2.10172355163678e-11 3.87262024792333e-09 2.21082432973189 0.447619047619048 25.2 25 2 decreased hair follicle number 5.40540927168586e-05 0.00123334196147304 2.20958646616541 0.447368421052632 25.2 25 2 abnormal maxilla morphology 1.92157442141817e-06 7.96652728879614e-05 2.19514472455649 0.444444444444444 25.2 25 2 abnormal atrioventricular cushion morphology 0.000729274842892654 0.00977935941614812 2.19514472455649 0.444444444444444 25.2 25 2 abnormal heart shape 0.00567986201853497 0.0444297382739174 2.19514472455649 0.444444444444444 25.2 25 2 thick dermal layer 0.00567986201853497 0.0444297382739174 2.19514472455649 0.444444444444444 25.2 25 2 abnormal thymus medulla morphology 0.00567986201853497 0.0444297382739174 2.19514472455649 0.444444444444444 25.2 25 2 absent inner cell mass 0.00567986201853497 0.0444297382739174 2.19514472455649 0.444444444444444 25.2 25 2 abnormal anterior eye segment morphology 0.00567986201853497 0.0444297382739174 2.19514472455649 0.444444444444444 25.2 25 2 darkened coat color 0.00567986201853497 0.0444297382739174 2.19514472455649 0.444444444444444 25.2 25 2 abnormal pregnancy 0.00567986201853497 0.0444297382739174 2.19514472455649 0.444444444444444 25.2 25 2 increased effector memory CD4-positive, alpha-beta T cell number 0.00567986201853497 0.0444297382739174 2.19514472455649 0.444444444444444 25.2 25 2 decreased oxygen consumption 2.46729804268994e-05 0.000678166174717263 2.18238225522767 0.441860465116279 25.2 25 2 anophthalmia 2.21361647256012e-09 2.36960166403703e-07 2.16431404022283 0.438202247191011 25.2 25 2 small heart 1.12672965138026e-05 0.000359325642026717 2.16084558823529 0.4375 25.2 25 2 increased fatty acid level 0.000325983886576445 0.00526548647960329 2.16084558823529 0.4375 25.2 25 2 failure of tooth eruption 0.0106319918694876 0.0707141170463913 2.16084558823529 0.4375 25.2 25 2 decreased mast cell number 0.0106319918694876 0.0707141170463913 2.16084558823529 0.4375 25.2 25 2 disorganized yolk sac vascular plexus 0.0106319918694876 0.0707141170463913 2.16084558823529 0.4375 25.2 25 2 increased cochlear outer hair cell number 0.0106319918694876 0.0707141170463913 2.16084558823529 0.4375 25.2 25 2 impaired somite development 0.0106319918694876 0.0707141170463913 2.16084558823529 0.4375 25.2 25 2 dilated respiratory conducting tubes 0.0106319918694876 0.0707141170463913 2.16084558823529 0.4375 25.2 25 2 abnormal skeletal muscle fiber morphology 1.05388339677392e-07 6.72188448583365e-06 2.15649781039176 0.436619718309859 25.2 25 2 abnormal pulmonary artery morphology 0.00246506102359871 0.0249769421433882 2.14742418706613 0.434782608695652 25.2 25 2 abnormal nasal cavity morphology 0.00246506102359871 0.0249769421433882 2.14742418706613 0.434782608695652 25.2 25 2 atrioventricular septal defect 5.14913667596284e-06 0.000180401091288135 2.14337244331695 0.433962264150943 25.2 25 2 abnormal trophoblast layer morphology 9.24710454060081e-06 0.000308753993889188 2.13058164442247 0.431372549019608 25.2 25 2 spina bifida 6.58982349805377e-05 0.00142540747403554 2.11674669867947 0.428571428571429 25.2 25 2 abnormal mitotic spindle morphology 0.00108195555125058 0.0132906885616584 2.11674669867947 0.428571428571429 25.2 25 2 small ears 0.00454160698548094 0.0396394644785398 2.11674669867947 0.428571428571429 25.2 25 2 liver degeneration 0.00454160698548094 0.0396394644785398 2.11674669867947 0.428571428571429 25.2 25 2 abnormal blood flow velocity 0.0199922956592694 0.109178563013025 2.11674669867947 0.428571428571429 25.2 25 2 abnormal kidney blood vessel morphology 0.0199922956592694 0.109178563013025 2.11674669867947 0.428571428571429 25.2 25 2 absent visceral yolk sac blood islands 0.0199922956592694 0.109178563013025 2.11674669867947 0.428571428571429 25.2 25 2 absent olfactory bulb 0.0199922956592694 0.109178563013025 2.11674669867947 0.428571428571429 25.2 25 2 abnormal sagittal suture morphology 0.0199922956592694 0.109178563013025 2.11674669867947 0.428571428571429 25.2 25 2 skeletal muscle necrosis 0.0199922956592694 0.109178563013025 2.11674669867947 0.428571428571429 25.2 25 2 split sternum 0.0199922956592694 0.109178563013025 2.11674669867947 0.428571428571429 25.2 25 2 abnormal squamosal bone morphology 0.0199922956592694 0.109178563013025 2.11674669867947 0.428571428571429 25.2 25 2 lysosomal protein accumulation 0.0199922956592694 0.109178563013025 2.11674669867947 0.428571428571429 25.2 25 2 increased pulmonary respiratory rate 0.0199922956592694 0.109178563013025 2.11674669867947 0.428571428571429 25.2 25 2 abnormal renal tubule epithelial cell primary cilium morphology 0.0199922956592694 0.109178563013025 2.11674669867947 0.428571428571429 25.2 25 2 multiple persisting craniopharyngeal ducts 0.0199922956592694 0.109178563013025 2.11674669867947 0.428571428571429 25.2 25 2 abnormal vitelline vein topology 0.0199922956592694 0.109178563013025 2.11674669867947 0.428571428571429 25.2 25 2 hemorrhage 1.29932524326527e-20 7.18238120582747e-18 2.10173431074557 0.425531914893617 25.2 25 2 abnormal vascular development 8.79894452340541e-07 4.20911048114826e-05 2.09536541889483 0.424242424242424 25.2 25 2 increased osteoblast cell number 0.000478932914057666 0.00698736436198501 2.09536541889483 0.424242424242424 25.2 25 2 abnormal placenta vasculature 1.34867614590803e-05 0.000421991435590719 2.08960892049127 0.423076923076923 25.2 25 2 abnormal nasal bone morphology 0.00197192290034418 0.0210071015614824 2.08960892049127 0.423076923076923 25.2 25 2 abnormal ocular fundus morphology 0.00197192290034418 0.0210071015614824 2.08960892049127 0.423076923076923 25.2 25 2 abnormal Mullerian duct morphology 0.00197192290034418 0.0210071015614824 2.08960892049127 0.423076923076923 25.2 25 2 albuminuria 5.33675072743779e-05 0.00122918216986125 2.08538748832866 0.422222222222222 25.2 25 2 abnormal cell migration 5.33675072743779e-05 0.00122918216986125 2.08538748832866 0.422222222222222 25.2 25 2 increased hepatocellular carcinoma incidence 6.12327491979983e-06 0.000210091673972443 2.07961079168509 0.421052631578947 25.2 25 2 incomplete somite formation 0.00021339847274358 0.00372511369087477 2.07961079168509 0.421052631578947 25.2 25 2 increased susceptibility to ischemic brain injury 0.00838016119457062 0.0603347350839202 2.07961079168509 0.421052631578947 25.2 25 2 eyelids fail to open 0.00838016119457062 0.0603347350839202 2.07961079168509 0.421052631578947 25.2 25 2 pale kidney 0.000866052431214094 0.0111046671270364 2.07122526429927 0.419354838709677 25.2 25 2 small cranium 0.000866052431214094 0.0111046671270364 2.07122526429927 0.419354838709677 25.2 25 2 abnormal neuromuscular synapse morphology 5.79280920696781e-07 3.03360271628051e-05 2.05794817927171 0.416666666666667 25.2 25 2 abnormal digit morphology 5.79280920696781e-07 3.03360271628051e-05 2.05794817927171 0.416666666666667 25.2 25 2 oligodactyly 4.29908074866124e-05 0.00103323317510095 2.05794817927171 0.416666666666667 25.2 25 2 abnormal osteoclast morphology 4.29908074866124e-05 0.00103323317510095 2.05794817927171 0.416666666666667 25.2 25 2 abnormal malleus morphology 0.00359438806715039 0.0333620907352112 2.05794817927171 0.416666666666667 25.2 25 2 abnormal vasodilation 0.00359438806715039 0.0333620907352112 2.05794817927171 0.416666666666667 25.2 25 2 abnormal rectum morphology 0.0377997560467044 0.162535683951905 2.05794817927171 0.416666666666667 25.2 25 2 abnormal mating frequency 0.0377997560467044 0.162535683951905 2.05794817927171 0.416666666666667 25.2 25 2 abnormal thymus involution 0.0377997560467044 0.162535683951905 2.05794817927171 0.416666666666667 25.2 25 2 altered tumor susceptibility 0.0377997560467044 0.162535683951905 2.05794817927171 0.416666666666667 25.2 25 2 abnormal alisphenoid bone morphology 0.0377997560467044 0.162535683951905 2.05794817927171 0.416666666666667 25.2 25 2 abnormal vascular endothelial cell development 0.0377997560467044 0.162535683951905 2.05794817927171 0.416666666666667 25.2 25 2 increased osteosarcoma incidence 0.0377997560467044 0.162535683951905 2.05794817927171 0.416666666666667 25.2 25 2 abnormal fatty acid level 0.0377997560467044 0.162535683951905 2.05794817927171 0.416666666666667 25.2 25 2 decreased keratinocyte proliferation 0.0377997560467044 0.162535683951905 2.05794817927171 0.416666666666667 25.2 25 2 decreased prostaglandin level 0.0377997560467044 0.162535683951905 2.05794817927171 0.416666666666667 25.2 25 2 enlarged kidney 1.94037854987118e-05 0.0005612432142796 2.05018233708578 0.415094339622642 25.2 25 2 abnormal cell differentiation 0.000171012551407456 0.00312789501195623 2.04790940766551 0.414634146341463 25.2 25 2 hemopericardium 0.000171012551407456 0.00312789501195623 2.04790940766551 0.414634146341463 25.2 25 2 abnormal embryonic erythropoiesis 0.00156515882194726 0.0176969662254264 2.04375543320777 0.413793103448276 25.2 25 2 decreased birth body size 6.43025475832644e-10 8.88625483963167e-08 2.03628556685832 0.412280701754386 25.2 25 2 abnormal lung development 9.77239128632118e-08 6.48235288659305e-06 2.03373702422145 0.411764705882353 25.2 25 2 small lung 3.44816676753142e-05 0.00088425926126128 2.03373702422145 0.411764705882353 25.2 25 2 increased brain size 0.0154872413396891 0.0957664941232414 2.03373702422145 0.411764705882353 25.2 25 2 abnormal ductus venosus valve morphology 0.0154872413396891 0.0957664941232414 2.03373702422145 0.411764705882353 25.2 25 2 short mandible 1.55684352874747e-05 0.000469411912455675 2.02854891956783 0.410714285714286 25.2 25 2 abnormal eye development 1.55684352874747e-05 0.000469411912455675 2.02854891956783 0.410714285714286 25.2 25 2 abnormal basisphenoid bone morphology 0.00655134989862433 0.0504535073462168 2.02053093964859 0.409090909090909 25.2 25 2 intracerebral hemorrhage 0.00655134989862433 0.0504535073462168 2.02053093964859 0.409090909090909 25.2 25 2 increased coping response 0.00655134989862433 0.0504535073462168 2.02053093964859 0.409090909090909 25.2 25 2 aphakia 0.00655134989862433 0.0504535073462168 2.02053093964859 0.409090909090909 25.2 25 2 decreased circulating estradiol level 0.00655134989862433 0.0504535073462168 2.02053093964859 0.409090909090909 25.2 25 2 abnormal mesenteric lymph node morphology 0.00655134989862433 0.0504535073462168 2.02053093964859 0.409090909090909 25.2 25 2 increased adenoma incidence 0.00655134989862433 0.0504535073462168 2.02053093964859 0.409090909090909 25.2 25 2 embryonic lethality before implantation, incomplete penetrance 0.00655134989862433 0.0504535073462168 2.02053093964859 0.409090909090909 25.2 25 2 abnormal vitelline vasculature morphology 9.10420653804436e-10 1.13716495891883e-07 2.01857873584216 0.408695652173913 25.2 25 2 abnormal chondrocyte morphology 2.75575395272556e-05 0.000731203511811643 2.01221599751012 0.407407407407407 25.2 25 2 increased cell proliferation 2.75575395272556e-05 0.000731203511811643 2.01221599751012 0.407407407407407 25.2 25 2 abnormal embryo size 1.59478281225523e-09 1.88905821213566e-07 2.01059715921767 0.407079646017699 25.2 25 2 abnormal vertebral body morphology 0.00123557301438722 0.0146356565394677 2.00649947478992 0.40625 25.2 25 2 increased fibroblast apoptosis 0.00123557301438722 0.0146356565394677 2.00649947478992 0.40625 25.2 25 2 malocclusion 0.000545386172489767 0.00777448770239711 2.00232795821031 0.405405405405405 25.2 25 2 impaired skeletal muscle contractility 0.000545386172489767 0.00777448770239711 2.00232795821031 0.405405405405405 25.2 25 2 decreased width of hypertrophic chondrocyte zone 0.000545386172489767 0.00777448770239711 2.00232795821031 0.405405405405405 25.2 25 2 abnormal muscle physiology 1.10761787973177e-07 6.97518854641208e-06 1.99782834482107 0.404494382022472 25.2 25 2 abnormal cell morphology 2.23861865748222e-09 2.36960166403703e-07 1.99296034203155 0.403508771929825 25.2 25 2 abnormal head morphology 3.86585680411951e-05 0.00095785863886405 1.97563025210084 0.4 25.2 25 2 abnormal platelet physiology 3.86585680411951e-05 0.00095785863886405 1.97563025210084 0.4 25.2 25 2 abnormal dermal layer morphology 0.000971618513025528 0.0122997508964427 1.97563025210084 0.4 25.2 25 2 abnormal hippocampus pyramidal cell morphology 0.000971618513025528 0.0122997508964427 1.97563025210084 0.4 25.2 25 2 embryonic lethality between implantation and somite formation, complete penetrance 5.45572373299053e-18 2.08786350550984e-15 1.97563025210084 0.4 25.2 25 2 delayed bone ossification 1.63036875195283e-06 6.93255088971397e-05 1.97563025210084 0.4 25.2 25 2 abnormal limb morphology 1.63036875195283e-06 6.93255088971397e-05 1.97563025210084 0.4 25.2 25 2 absent mesoderm 1.74517554699312e-05 0.000515144419126965 1.97563025210084 0.4 25.2 25 2 intracranial hemorrhage 1.74517554699312e-05 0.000515144419126965 1.97563025210084 0.4 25.2 25 2 abnormal brain vasculature morphology 0.00221273642320193 0.0230783306193493 1.97563025210084 0.4 25.2 25 2 abnormal cellular respiration 0.00221273642320193 0.0230783306193493 1.97563025210084 0.4 25.2 25 2 spontaneous skin ulceration 0.005097385776841 0.0415049005561113 1.97563025210084 0.4 25.2 25 2 decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 0.005097385776841 0.0415049005561113 1.97563025210084 0.4 25.2 25 2 macrocytosis 0.0286647423772419 0.136466118016056 1.97563025210084 0.4 25.2 25 2 decreased hepatocyte number 0.0286647423772419 0.136466118016056 1.97563025210084 0.4 25.2 25 2 abnormal prostate gland morphology 0.0286647423772419 0.136466118016056 1.97563025210084 0.4 25.2 25 2 absent egg cylinders 0.0286647423772419 0.136466118016056 1.97563025210084 0.4 25.2 25 2 placental labyrinth hypoplasia 0.0286647423772419 0.136466118016056 1.97563025210084 0.4 25.2 25 2 abnormal cricoid cartilage morphology 0.0286647423772419 0.136466118016056 1.97563025210084 0.4 25.2 25 2 arthritis 0.0286647423772419 0.136466118016056 1.97563025210084 0.4 25.2 25 2 dilated ureter 0.0286647423772419 0.136466118016056 1.97563025210084 0.4 25.2 25 2 decreased aggression towards males 0.0286647423772419 0.136466118016056 1.97563025210084 0.4 25.2 25 2 abnormal ear development 0.0286647423772419 0.136466118016056 1.97563025210084 0.4 25.2 25 2 abnormal cerebral aqueduct morphology 0.0286647423772419 0.136466118016056 1.97563025210084 0.4 25.2 25 2 abnormal microglial cell activation 0.0286647423772419 0.136466118016056 1.97563025210084 0.4 25.2 25 2 herniated liver 0.0286647423772419 0.136466118016056 1.97563025210084 0.4 25.2 25 2 abnormal vascular regression 0.0119363515406461 0.078238931376435 1.97563025210084 0.4 25.2 25 2 spleen atrophy 0.0119363515406461 0.078238931376435 1.97563025210084 0.4 25.2 25 2 abnormal heart right ventricle morphology 0.0119363515406461 0.078238931376435 1.97563025210084 0.4 25.2 25 2 abnormal optic stalk morphology 0.0119363515406461 0.078238931376435 1.97563025210084 0.4 25.2 25 2 kidney atrophy 0.0119363515406461 0.078238931376435 1.97563025210084 0.4 25.2 25 2 abnormal sperm mitochondrial sheath morphology 0.0119363515406461 0.078238931376435 1.97563025210084 0.4 25.2 25 2 increased skin tumor incidence 0.0119363515406461 0.078238931376435 1.97563025210084 0.4 25.2 25 2 embryonic growth arrest 1.34427544479774e-16 3.93398255168751e-14 1.96268944258926 0.397379912663755 25.2 25 2 abnormal mesoderm development 6.79323046870448e-05 0.00146304422432055 1.95699223085461 0.39622641509434 25.2 25 2 vertebral transformation 0.000151302337466886 0.00281921022059086 1.95505077030812 0.395833333333333 25.2 25 2 increased grip strength 2.14715159562516e-07 1.25671519861591e-05 1.95392002955028 0.395604395604396 25.2 25 2 abnormal vasculogenesis 0.000338546738939926 0.00545071205898425 1.95265780730897 0.395348837209302 25.2 25 2 decreased neuron apoptosis 0.000761899889715539 0.0100809892322734 1.94963511720478 0.394736842105263 25.2 25 2 pallor 9.3302781047552e-13 2.01817972048509e-10 1.94740696278511 0.394285714285714 25.2 25 2 decreased circulating serum albumin level 7.80625605980277e-08 5.35742735565229e-06 1.94569646040234 0.393939393939394 25.2 25 2 single kidney 0.00172738907960143 0.0189707741082055 1.94569646040234 0.393939393939394 25.2 25 2 abnormal QRS complex 0.00172738907960143 0.0189707741082055 1.94569646040234 0.393939393939394 25.2 25 2 abnormal middle ear ossicle morphology 0.00172738907960143 0.0189707741082055 1.94569646040234 0.393939393939394 25.2 25 2 anemia 5.67752674188704e-15 1.48661555478358e-12 1.942859134175 0.393364928909953 25.2 25 2 rib bifurcation 0.00395490030893073 0.0359700713655034 1.94035114045618 0.392857142857143 25.2 25 2 increased triglyceride level 0.00395490030893073 0.0359700713655034 1.94035114045618 0.392857142857143 25.2 25 2 corneal vascularization 0.00395490030893073 0.0359700713655034 1.94035114045618 0.392857142857143 25.2 25 2 distended abdomen 0.000119118677306899 0.00233313157323552 1.93689240402043 0.392156862745098 25.2 25 2 abnormal gluconeogenesis 0.000119118677306899 0.00233313157323552 1.93689240402043 0.392156862745098 25.2 25 2 pale liver 3.93539824277473e-06 0.000142909534728498 1.93558369293663 0.391891891891892 25.2 25 2 kidney cysts 3.93539824277473e-06 0.000142909534728498 1.93558369293663 0.391891891891892 25.2 25 2 abnormal cell death 0.000265818132038047 0.00445267746427368 1.93268176835952 0.391304347826087 25.2 25 2 abnormal basicranium morphology 0.00917824988971223 0.0637102341855027 1.93268176835952 0.391304347826087 25.2 25 2 abnormal hematopoietic stem cell physiology 0.00917824988971223 0.0637102341855027 1.93268176835952 0.391304347826087 25.2 25 2 abnormal skeleton morphology 1.03482637272545e-08 8.58043534051522e-07 1.93268176835952 0.391304347826087 25.2 25 2 increased tumor growth/size 0.000596202175841348 0.00837883001358956 1.92744414839106 0.390243902439024 25.2 25 2 short humerus 0.000596202175841348 0.00837883001358956 1.92744414839106 0.390243902439024 25.2 25 2 perinatal lethality, incomplete penetrance 1.8050941128923e-15 4.98907956202177e-13 1.9231798914256 0.389380530973451 25.2 25 2 cleft palate 1.37594544487117e-09 1.66959233859368e-07 1.92284623773173 0.389312977099237 25.2 25 2 impaired limb coordination 9.36253370614564e-05 0.00193272220697405 1.92075163398693 0.388888888888889 25.2 25 2 abnormal cell adhesion 9.36253370614564e-05 0.00193272220697405 1.92075163398693 0.388888888888889 25.2 25 2 heart right ventricle hypertrophy 0.00134581405007358 0.0157539409390966 1.92075163398693 0.388888888888889 25.2 25 2 short radius 0.00134581405007358 0.0157539409390966 1.92075163398693 0.388888888888889 25.2 25 2 abnormal trophoblast giant cell morphology 0.00134581405007358 0.0157539409390966 1.92075163398693 0.388888888888889 25.2 25 2 abnormal mammary gland morphology 0.0217283009076963 0.116989498934836 1.92075163398693 0.388888888888889 25.2 25 2 abnormal thyroid cartilage morphology 0.0217283009076963 0.116989498934836 1.92075163398693 0.388888888888889 25.2 25 2 absent allantois 0.0217283009076963 0.116989498934836 1.92075163398693 0.388888888888889 25.2 25 2 decreased pulmonary respiratory rate 0.0217283009076963 0.116989498934836 1.92075163398693 0.388888888888889 25.2 25 2 primary atelectasis 0.0217283009076963 0.116989498934836 1.92075163398693 0.388888888888889 25.2 25 2 rib fusion 1.504975587488e-05 0.000459340708451093 1.9166562147247 0.388059701492537 25.2 25 2 decreased neuronal precursor cell number 0.00306327368129952 0.0298234570733173 1.91190024396856 0.387096774193548 25.2 25 2 decreased double-negative T cell number 0.00306327368129952 0.0298234570733173 1.91190024396856 0.387096774193548 25.2 25 2 abnormal facial morphology 7.3488143357922e-05 0.00156911379058224 1.906309892378 0.385964912280702 25.2 25 2 abnormal heart ventricle morphology 4.24370249257271e-06 0.000151887912953592 1.89964447317389 0.384615384615385 25.2 25 2 abnormal iris morphology 0.00104707862213864 0.0129815065233546 1.89964447317389 0.384615384615385 25.2 25 2 increased vascular permeability 0.00104707862213864 0.0129815065233546 1.89964447317389 0.384615384615385 25.2 25 2 increased hepatocyte apoptosis 0.00104707862213864 0.0129815065233546 1.89964447317389 0.384615384615385 25.2 25 2 abnormal response to injury 0.00104707862213864 0.0129815065233546 1.89964447317389 0.384615384615385 25.2 25 2 abnormal stomach morphology 0.00705080007465155 0.0528279071858305 1.89964447317389 0.384615384615385 25.2 25 2 abnormal Schwann cell morphology 0.00705080007465155 0.0528279071858305 1.89964447317389 0.384615384615385 25.2 25 2 increased susceptibility to otitis media 0.00705080007465155 0.0528279071858305 1.89964447317389 0.384615384615385 25.2 25 2 abnormal nerve conduction 0.00705080007465155 0.0528279071858305 1.89964447317389 0.384615384615385 25.2 25 2 increased thymocyte apoptosis 0.00705080007465155 0.0528279071858305 1.89964447317389 0.384615384615385 25.2 25 2 absent myocardial trabeculae 0.0531188321665415 0.211075231652192 1.89964447317389 0.384615384615385 25.2 25 2 short hair 0.0531188321665415 0.211075231652192 1.89964447317389 0.384615384615385 25.2 25 2 abnormal lung interstitium morphology 0.0531188321665415 0.211075231652192 1.89964447317389 0.384615384615385 25.2 25 2 abnormal telomere length 0.0531188321665415 0.211075231652192 1.89964447317389 0.384615384615385 25.2 25 2 absent lateral semicircular canal 0.0531188321665415 0.211075231652192 1.89964447317389 0.384615384615385 25.2 25 2 muscle fatigue 0.0531188321665415 0.211075231652192 1.89964447317389 0.384615384615385 25.2 25 2 decreased endocochlear potential 0.0531188321665415 0.211075231652192 1.89964447317389 0.384615384615385 25.2 25 2 orthokeratosis 0.0531188321665415 0.211075231652192 1.89964447317389 0.384615384615385 25.2 25 2 absent hypoglossal nerve 0.0531188321665415 0.211075231652192 1.89964447317389 0.384615384615385 25.2 25 2 abnormal cell nucleus morphology 0.000363507923534264 0.00570489564537212 1.89156087967102 0.382978723404255 25.2 25 2 neuron degeneration 0.000363507923534264 0.00570489564537212 1.89156087967102 0.382978723404255 25.2 25 2 ventricular septal defect 2.01236932088083e-09 2.22478608252936e-07 1.88847009391992 0.382352941176471 25.2 25 2 increased width of hypertrophic chondrocyte zone 0.0023702823197609 0.024213869693656 1.88847009391992 0.382352941176471 25.2 25 2 abnormal T-helper 2 physiology 0.000127575400279851 0.00248897104467553 1.88582887700535 0.381818181818182 25.2 25 2 prenatal lethality, complete penetrance 1.46233789064986e-17 5.19652214713077e-15 1.88324466477238 0.381294964028777 25.2 25 2 hydronephrosis 2.62509105668531e-06 0.000107047770549258 1.88155262104842 0.380952380952381 25.2 25 2 abnormal cartilage morphology 0.000813871030772787 0.0105994983719754 1.88155262104842 0.380952380952381 25.2 25 2 abnormal pancreas morphology 0.000813871030772787 0.0105994983719754 1.88155262104842 0.380952380952381 25.2 25 2 abnormal scapula morphology 0.0164869635745939 0.0957664941232414 1.88155262104842 0.380952380952381 25.2 25 2 complete atrioventricular septal defect 0.0164869635745939 0.0957664941232414 1.88155262104842 0.380952380952381 25.2 25 2 absent segment of posterior cerebral artery 0.0164869635745939 0.0957664941232414 1.88155262104842 0.380952380952381 25.2 25 2 perinatal lethality, complete penetrance 1.06460416788651e-13 2.5220979691597e-11 1.87824002840573 0.380281690140845 25.2 25 2 abnormal hindlimb morphology 0.000283417838535355 0.00468894075192882 1.8768487394958 0.38 25.2 25 2 increased B cell derived lymphoma incidence 0.000283417838535355 0.00468894075192882 1.8768487394958 0.38 25.2 25 2 decreased B cell proliferation 5.7449219966608e-06 0.00019986704149222 1.87559834060206 0.379746835443038 25.2 25 2 blood in lymph vessels 0.00541529788430952 0.0437355632701946 1.87344248044045 0.379310344827586 25.2 25 2 insulin resistance 5.88313596571579e-09 5.04631059128208e-07 1.8708619811561 0.378787878787879 25.2 25 2 abnormal craniofacial morphology 2.68077238652766e-07 1.55079565383432e-05 1.8701354328139 0.378640776699029 25.2 25 2 increased erythroid progenitor cell number 0.00183303101903763 0.0199985292098952 1.86883942766296 0.378378378378378 25.2 25 2 abnormal long bone morphology 7.78443691893397e-05 0.00164798185837006 1.86227441796391 0.377049180327869 25.2 25 2 thymus hypoplasia 3.64635333810902e-09 3.70216486879437e-07 1.86110096212398 0.376811594202899 25.2 25 2 abnormal sternum morphology 2.76314090895656e-05 0.000731203511811643 1.86110096212398 0.376811594202899 25.2 25 2 microcephaly 2.76314090895656e-05 0.000731203511811643 1.86110096212398 0.376811594202899 25.2 25 2 increased lymphocyte cell number 2.76314090895656e-05 0.000731203511811643 1.86110096212398 0.376811594202899 25.2 25 2 decreased embryo size 4.58030491845547e-28 3.79783616155266e-25 1.8599029569987 0.376569037656904 25.2 25 2 abnormal definitive hematopoiesis 1.27055121817189e-06 5.74635664582289e-05 1.85879190385832 0.376344086021505 25.2 25 2 abnormal osteoclast physiology 6.07537825072641e-05 0.00137386394533472 1.85215336134454 0.375 25.2 25 2 abnormal spongiotrophoblast layer morphology 0.0041598940814469 0.0374917990130405 1.85215336134454 0.375 25.2 25 2 pancreatic islet hyperplasia 0.0041598940814469 0.0374917990130405 1.85215336134454 0.375 25.2 25 2 decreased metastatic potential 0.0125285669832493 0.0809084299122388 1.85215336134454 0.375 25.2 25 2 abnormal nursing 0.0125285669832493 0.0809084299122388 1.85215336134454 0.375 25.2 25 2 increased body temperature 0.0125285669832493 0.0809084299122388 1.85215336134454 0.375 25.2 25 2 abnormal bone marrow cell number 0.0394843926818946 0.167606530368964 1.85215336134454 0.375 25.2 25 2 impaired muscle relaxation 0.0394843926818946 0.167606530368964 1.85215336134454 0.375 25.2 25 2 bowed tibia 0.0394843926818946 0.167606530368964 1.85215336134454 0.375 25.2 25 2 blepharitis 0.0394843926818946 0.167606530368964 1.85215336134454 0.375 25.2 25 2 abnormal embryonic tissue morphology 1.77353269475939e-09 2.05193608289023e-07 1.84795346710113 0.374149659863946 25.2 25 2 abnormal cell cycle 1.02045625895819e-07 6.59320764716495e-06 1.84678480087687 0.373913043478261 25.2 25 2 abnormal heart development 5.07421507062743e-10 7.57933312092569e-08 1.8443383682587 0.373417721518987 25.2 25 2 failure of chorioallantoic fusion 0.000380970465514749 0.00589584151293809 1.84004778381941 0.372549019607843 25.2 25 2 edema 1.14150759902675e-10 1.83193558230906e-08 1.83779558334962 0.372093023255814 25.2 25 2 abnormal cornea morphology 1.31844512758503e-05 0.000415143323400984 1.83632299073476 0.371794871794872 25.2 25 2 embryonic lethality between somite formation and embryo turning, complete penetrance 3.69590611127091e-05 0.000938119025692489 1.83451380552221 0.371428571428571 25.2 25 2 ovary cysts 0.00319676547828634 0.0307619115173588 1.83451380552221 0.371428571428571 25.2 25 2 decreased triglyceride level 0.00319676547828634 0.0307619115173588 1.83451380552221 0.371428571428571 25.2 25 2 impaired adaptive thermogenesis 0.00319676547828634 0.0307619115173588 1.83451380552221 0.371428571428571 25.2 25 2 pericardial effusion 0.000104166135018053 0.00210661187688949 1.8322377338032 0.370967741935484 25.2 25 2 abnormal apoptosis 0.000295643720969938 0.00482238528467358 1.82928727046374 0.37037037037037 25.2 25 2 abnormal long bone epiphyseal plate proliferative zone 0.000295643720969938 0.00482238528467358 1.82928727046374 0.37037037037037 25.2 25 2 thin epidermis 0.00953583338924532 0.0645120079435379 1.82928727046374 0.37037037037037 25.2 25 2 decreased hematocrit 3.99600166155799e-09 3.89806044436294e-07 1.8267813974905 0.36986301369863 25.2 25 2 embryonic lethality during organogenesis, complete penetrance 8.36169468783677e-31 1.66965068154669e-27 1.82569402761104 0.369642857142857 25.2 25 2 delayed wound healing 0.000846948027790263 0.0109728292662931 1.82531055900621 0.369565217391304 25.2 25 2 atrial septal defect 0.000846948027790263 0.0109728292662931 1.82531055900621 0.369565217391304 25.2 25 2 prenatal lethality, incomplete penetrance 3.49780278713041e-17 1.08759805412336e-14 1.81965944272446 0.368421052631579 25.2 25 2 persistence of hyaloid vascular system 0.00245785751114219 0.0249769421433882 1.81965944272446 0.368421052631579 25.2 25 2 impaired branching involved in ureteric bud morphogenesis 0.00245785751114219 0.0249769421433882 1.81965944272446 0.368421052631579 25.2 25 2 abnormal triglyceride level 0.0295147157403529 0.138393695389496 1.81965944272446 0.368421052631579 25.2 25 2 abnormal nail morphology 0.0295147157403529 0.138393695389496 1.81965944272446 0.368421052631579 25.2 25 2 thin dermal layer 0.0295147157403529 0.138393695389496 1.81965944272446 0.368421052631579 25.2 25 2 abnormal stationary movement 0.0295147157403529 0.138393695389496 1.81965944272446 0.368421052631579 25.2 25 2 abnormal neural crest cell migration 0.0295147157403529 0.138393695389496 1.81965944272446 0.368421052631579 25.2 25 2 abnormal digestive system development 0.0295147157403529 0.138393695389496 1.81965944272446 0.368421052631579 25.2 25 2 oliguria 0.0295147157403529 0.138393695389496 1.81965944272446 0.368421052631579 25.2 25 2 abnormal sternebra morphology 0.0295147157403529 0.138393695389496 1.81965944272446 0.368421052631579 25.2 25 2 decreased susceptibility to weight gain 0.0295147157403529 0.138393695389496 1.81965944272446 0.368421052631579 25.2 25 2 extramedullary hematopoiesis 6.35934875251973e-07 3.22834286161078e-05 1.81720707150785 0.367924528301887 25.2 25 2 pericardial edema 6.3040559903181e-05 0.00141273326810056 1.81583662876915 0.367647058823529 25.2 25 2 abnormal placenta morphology 1.74993782577803e-05 0.000515144419126965 1.81307839591533 0.367088607594937 25.2 25 2 abnormal eye morphology 1.45295353624103e-08 1.14737203853954e-06 1.81217882836588 0.366906474820144 25.2 25 2 thin ventricular wall 4.89353240704403e-06 0.000172661870390383 1.8109943977591 0.366666666666667 25.2 25 2 abnormal kidney development 0.000177997137330315 0.00320846289209536 1.8109943977591 0.366666666666667 25.2 25 2 abnormal incisor morphology 0.000177997137330315 0.00320846289209536 1.8109943977591 0.366666666666667 25.2 25 2 muscular ventricular septal defect 0.000177997137330315 0.00320846289209536 1.8109943977591 0.366666666666667 25.2 25 2 abnormal lactation 0.00726941241442444 0.0540333371879884 1.8109943977591 0.366666666666667 25.2 25 2 abnormal optic cup morphology 0.00726941241442444 0.0540333371879884 1.8109943977591 0.366666666666667 25.2 25 2 abnormal fat pad morphology 0.00726941241442444 0.0540333371879884 1.8109943977591 0.366666666666667 25.2 25 2 abnormal snout morphology 0.000506395009817261 0.00732359062163045 1.80466224951519 0.365384615384615 25.2 25 2 kinked neural tube 0.000506395009817261 0.00732359062163045 1.80466224951519 0.365384615384615 25.2 25 2 increased granulocyte number 3.81327341412342e-05 0.00095785863886405 1.80209516238928 0.364864864864865 25.2 25 2 respiratory failure 5.4505232629558e-09 4.84220593450091e-07 1.79900105737659 0.364238410596026 25.2 25 2 embryonic lethality, complete penetrance 3.00785437859095e-17 9.97605035565997e-15 1.79602750190986 0.363636363636364 25.2 25 2 dilated heart atrium 0.00554989693964431 0.0439661421572141 1.79602750190986 0.363636363636364 25.2 25 2 increased T cell number 8.27328265223913e-06 0.000281914939691025 1.79602750190985 0.363636363636364 25.2 25 2 abnormal astrocyte morphology 0.00145539217013109 0.0166068257945004 1.79602750190985 0.363636363636364 25.2 25 2 muscular atrophy 0.00145539217013109 0.0166068257945004 1.79602750190985 0.363636363636364 25.2 25 2 decreased sensitivity to induced morbidity/mortality 0.00145539217013109 0.0166068257945004 1.79602750190985 0.363636363636364 25.2 25 2 intestinal inflammation 0.0221644571037193 0.118186681769564 1.79602750190985 0.363636363636364 25.2 25 2 testis hypoplasia 0.0221644571037193 0.118186681769564 1.79602750190985 0.363636363636364 25.2 25 2 abnormal retinal layer morphology 0.0221644571037193 0.118186681769564 1.79602750190985 0.363636363636364 25.2 25 2 prolonged PR interval 0.0221644571037193 0.118186681769564 1.79602750190985 0.363636363636364 25.2 25 2 abnormal circulating lipid level 0.0221644571037193 0.118186681769564 1.79602750190985 0.363636363636364 25.2 25 2 abnormal occipital bone morphology 0.0221644571037193 0.118186681769564 1.79602750190985 0.363636363636364 25.2 25 2 rough coat 0.0221644571037193 0.118186681769564 1.79602750190985 0.363636363636364 25.2 25 2 glomerulosclerosis 0.000303025969313602 0.00492664770370971 1.7882860040568 0.362068965517241 25.2 25 2 increased cellular sensitivity to gamma-irradiation 0.001120897420202 0.013701387384533 1.78647416413374 0.361702127659574 25.2 25 2 abnormal lipid homeostasis 8.82787484225167e-08 5.9349563973246e-06 1.78566580478345 0.361538461538462 25.2 25 2 abnormal forebrain development 6.45358919843172e-05 0.00142054133538522 1.78355508870215 0.361111111111111 25.2 25 2 narrow eye opening 0.00424295541597181 0.0380336994494771 1.78355508870215 0.361111111111111 25.2 25 2 abnormal retinal blood vessel morphology 0.00424295541597181 0.0380336994494771 1.78355508870215 0.361111111111111 25.2 25 2 embryonic lethality during organogenesis, incomplete penetrance 1.4615241437773e-12 3.0296177563717e-10 1.78236207526489 0.360869565217391 25.2 25 2 increased osteoclast cell number 0.00023449357064061 0.00399522436279806 1.78130596500895 0.360655737704918 25.2 25 2 enlarged liver 3.04360513885758e-06 0.000115602277262639 1.77806722689076 0.36 25.2 25 2 decreased respiratory quotient 0.000863765166652682 0.0111046671270364 1.77806722689076 0.36 25.2 25 2 ruffled hair 0.016708606411854 0.0957664941232414 1.77806722689076 0.36 25.2 25 2 abnormal primitive streak morphology 0.016708606411854 0.0957664941232414 1.77806722689076 0.36 25.2 25 2 diaphragmatic hernia 0.016708606411854 0.0957664941232414 1.77806722689076 0.36 25.2 25 2 decreased rib number 1.08447024196285e-05 0.000350340224270464 1.77584741761873 0.359550561797753 25.2 25 2 small liver 3.88781561721208e-05 0.00095785863886405 1.77300150829563 0.358974358974359 25.2 25 2 impaired macrophage chemotaxis 0.0032478936889842 0.0311935735573289 1.77300150829563 0.358974358974359 25.2 25 2 abnormal blood vessel morphology 2.55901002359491e-08 1.95124052924833e-06 1.77125470878006 0.358620689655172 25.2 25 2 increased circulating bilirubin level 0.000665979872694488 0.00912700957622915 1.77061201839226 0.358490566037736 25.2 25 2 internal hemorrhage 0.000140526457067087 0.00265314421684362 1.76922112128433 0.358208955223881 25.2 25 2 abnormal vertebrae morphology 1.43717287985253e-06 6.32737617457196e-05 1.76719219798011 0.357798165137615 25.2 25 2 abnormal renal glomerulus morphology 1.43717287985253e-06 6.32737617457196e-05 1.76719219798011 0.357798165137615 25.2 25 2 abnormal coat/hair pigmentation 1.11910489158319e-06 5.1551359589133e-05 1.76395558223289 0.357142857142857 25.2 25 2 lymphoid hyperplasia 0.0126363517671979 0.0809084299122388 1.76395558223289 0.357142857142857 25.2 25 2 small superior cervical ganglion 0.0126363517671979 0.0809084299122388 1.76395558223289 0.357142857142857 25.2 25 2 premature aging 0.0126363517671979 0.0809084299122388 1.76395558223289 0.357142857142857 25.2 25 2 decreased circulating progesterone level 0.0126363517671979 0.0809084299122388 1.76395558223289 0.357142857142857 25.2 25 2 abnormal brainstem morphology 0.0126363517671979 0.0809084299122388 1.76395558223289 0.357142857142857 25.2 25 2 abnormal renal tubule epithelium morphology 0.0126363517671979 0.0809084299122388 1.76395558223289 0.357142857142857 25.2 25 2 prolonged QRS complex duration 0.0126363517671979 0.0809084299122388 1.76395558223289 0.357142857142857 25.2 25 2 midline facial cleft 0.0715224635594705 0.256729213563399 1.76395558223289 0.357142857142857 25.2 25 2 absent atrioventricular cushions 0.0715224635594705 0.256729213563399 1.76395558223289 0.357142857142857 25.2 25 2 megacephaly 0.0715224635594705 0.256729213563399 1.76395558223289 0.357142857142857 25.2 25 2 translucent skin 0.0715224635594705 0.256729213563399 1.76395558223289 0.357142857142857 25.2 25 2 abnormal placing response 0.0715224635594705 0.256729213563399 1.76395558223289 0.357142857142857 25.2 25 2 abnormal endplate potential 0.0715224635594705 0.256729213563399 1.76395558223289 0.357142857142857 25.2 25 2 intestinal obstruction 0.0715224635594705 0.256729213563399 1.76395558223289 0.357142857142857 25.2 25 2 abnormal imprinting 0.0715224635594705 0.256729213563399 1.76395558223289 0.357142857142857 25.2 25 2 pulmonary alveolar hemorrhage 0.0715224635594705 0.256729213563399 1.76395558223289 0.357142857142857 25.2 25 2 decreased response to antigen 0.0715224635594705 0.256729213563399 1.76395558223289 0.357142857142857 25.2 25 2 abnormal T cell differentiation 3.9671876424759e-06 0.00014301998928491 1.76046260088194 0.356435643564356 25.2 25 2 abnormal fertility/fecundity 8.42975470811398e-05 0.00176210208709525 1.75912282721308 0.356164383561644 25.2 25 2 decreased bone mineral content 5.02324185325616e-11 8.71115382824723e-09 1.75717113768584 0.355769230769231 25.2 25 2 abnormal rib morphology 1.1688317458884e-07 7.2686724197435e-06 1.75611577964519 0.355555555555556 25.2 25 2 abnormal myocardial trabeculae morphology 0.00190957674315018 0.0206076882801998 1.75611577964519 0.355555555555556 25.2 25 2 cardiomyopathy 0.00190957674315018 0.0206076882801998 1.75611577964519 0.355555555555556 25.2 25 2 abnormal eyelid morphology 0.00958278871764311 0.0645120079435379 1.75257522363784 0.354838709677419 25.2 25 2 abnormal object recognition memory 0.00958278871764311 0.0645120079435379 1.75257522363784 0.354838709677419 25.2 25 2 abnormal retinal photoreceptor layer morphology 0.00958278871764311 0.0645120079435379 1.75257522363784 0.354838709677419 25.2 25 2 preaxial polydactyly 0.00958278871764311 0.0645120079435379 1.75257522363784 0.354838709677419 25.2 25 2 decreased hemoglobin content 7.09838799459367e-08 4.97387046100049e-06 1.75144525895465 0.354609929078014 25.2 25 2 abnormal somite development 5.06155244388174e-05 0.00117804495755857 1.75055845122859 0.354430379746835 25.2 25 2 abnormal placenta labyrinth morphology 5.06155244388174e-05 0.00117804495755857 1.75055845122859 0.354430379746835 25.2 25 2 decreased bone mineral density 2.11280029766444e-13 4.77780976403663e-11 1.7453876287357 0.353383458646617 25.2 25 2 kyphosis 3.35903351376423e-08 2.42191184506914e-06 1.74514005602241 0.353333333333333 25.2 25 2 abnormal dendritic spine morphology 0.00112710773090974 0.0137435317678332 1.74320316361839 0.352941176470588 25.2 25 2 abnormal brown adipose tissue morphology 0.00728423218685342 0.0540333371879884 1.74320316361839 0.352941176470588 25.2 25 2 abnormal interatrial septum morphology 0.0525737479594612 0.210653695803884 1.74320316361839 0.352941176470588 25.2 25 2 increased incidence of corneal inflammation 0.0525737479594612 0.210653695803884 1.74320316361839 0.352941176470588 25.2 25 2 abnormal dorsal-ventral axis patterning 0.0525737479594612 0.210653695803884 1.74320316361839 0.352941176470588 25.2 25 2 decreased vasoconstriction 0.0525737479594612 0.210653695803884 1.74320316361839 0.352941176470588 25.2 25 2 abnormal duodenum morphology 0.0525737479594612 0.210653695803884 1.74320316361839 0.352941176470588 25.2 25 2 abnormal embryonic-extraembryonic boundary morphology 0.0525737479594612 0.210653695803884 1.74320316361839 0.352941176470588 25.2 25 2 coloboma 0.0525737479594612 0.210653695803884 1.74320316361839 0.352941176470588 25.2 25 2 abnormal tendon morphology 0.0525737479594612 0.210653695803884 1.74320316361839 0.352941176470588 25.2 25 2 increased trabecular bone mass 0.0525737479594612 0.210653695803884 1.74320316361839 0.352941176470588 25.2 25 2 decreased body fat mass 0.0525737479594612 0.210653695803884 1.74320316361839 0.352941176470588 25.2 25 2 abnormal ovary morphology 0.00014132325979167 0.00265314421684362 1.73911113741271 0.352112676056338 25.2 25 2 corneal opacity 0.00014132325979167 0.00265314421684362 1.73911113741271 0.352112676056338 25.2 25 2 short snout 3.10534140302015e-06 0.000117038435454737 1.73782290694055 0.351851851851852 25.2 25 2 abnormal B cell differentiation 1.82958559984444e-05 0.000532291716913805 1.73681780404469 0.351648351648352 25.2 25 2 abnormal branching of the mammary ductal tree 0.00554833113097783 0.0439661421572141 1.7353508971156 0.351351351351351 25.2 25 2 increased circulating phosphate level 0.00554833113097783 0.0439661421572141 1.7353508971156 0.351351351351351 25.2 25 2 increased insulin secretion 0.00554833113097783 0.0439661421572141 1.7353508971156 0.351351351351351 25.2 25 2 abnormal hair follicle development 0.00554833113097783 0.0439661421572141 1.7353508971156 0.351351351351351 25.2 25 2 abnormal calcium ion homeostasis 0.00554833113097783 0.0439661421572141 1.7353508971156 0.351351351351351 25.2 25 2 skin inflammation 0.00554833113097783 0.0439661421572141 1.7353508971156 0.351351351351351 25.2 25 2 abnormal humerus morphology 0.00554833113097783 0.0439661421572141 1.7353508971156 0.351351351351351 25.2 25 2 cleft secondary palate 1.41933489175783e-05 0.000436283269299408 1.7339308063651 0.351063829787234 25.2 25 2 absent vitelline blood vessels 0.000667451274445121 0.00912700957622915 1.73300899307091 0.350877192982456 25.2 25 2 abnormal myocardial fiber morphology 1.10127519098265e-05 0.000353473811299271 1.73122238586156 0.350515463917526 25.2 25 2 decreased erythrocyte cell number 2.62780131577162e-08 1.95124052924833e-06 1.73024942461061 0.35031847133758 25.2 25 2 decreased double-positive T cell number 8.5463803022162e-06 0.000289239741520582 1.72867647058824 0.35 25.2 25 2 increased erythrocyte cell number 0.000514176230217292 0.00739314088245961 1.72867647058824 0.35 25.2 25 2 perinatal lethality 0.00423367278348761 0.0380336994494771 1.72867647058824 0.35 25.2 25 2 brain inflammation 0.0389799887709643 0.166309349485744 1.72867647058824 0.35 25.2 25 2 abnormal trachea morphology 0.0389799887709643 0.166309349485744 1.72867647058824 0.35 25.2 25 2 decreased myocardial infarction size 0.0389799887709643 0.166309349485744 1.72867647058824 0.35 25.2 25 2 decreased skin tensile strength 0.0389799887709643 0.166309349485744 1.72867647058824 0.35 25.2 25 2 dilated vasculature 0.0389799887709643 0.166309349485744 1.72867647058824 0.35 25.2 25 2 abnormal incus morphology 0.0389799887709643 0.166309349485744 1.72867647058824 0.35 25.2 25 2 abnormal response to tactile stimuli 0.0389799887709643 0.166309349485744 1.72867647058824 0.35 25.2 25 2 postnatal lethality 1.24125956922955e-08 9.96010702728552e-07 1.72570112382302 0.349397590361446 25.2 25 2 pale yolk sac 5.06736926467403e-05 0.00117804495755857 1.72570112382302 0.349397590361446 25.2 25 2 abnormal hair follicle morphology 0.000396353912654848 0.00591961821119974 1.72475656929438 0.349206349206349 25.2 25 2 gliosis 0.000396353912654848 0.00591961821119974 1.72475656929438 0.349206349206349 25.2 25 2 abnormal kidney morphology 5.86365358624292e-09 5.04631059128208e-07 1.7216206482593 0.348571428571429 25.2 25 2 abnormal tail morphology 0.000305711851469693 0.00495412528033135 1.72119302266361 0.348484848484849 25.2 25 2 decreased T cell number 2.62642874587038e-08 1.95124052924833e-06 1.7179393496529 0.347826086956522 25.2 25 2 abnormal forelimb morphology 0.00247631205800879 0.0250399440825076 1.7179393496529 0.347826086956522 25.2 25 2 fragile skeleton 0.0290904342845231 0.137571207761884 1.7179393496529 0.347826086956522 25.2 25 2 abnormal blood vessel physiology 0.0290904342845231 0.137571207761884 1.7179393496529 0.347826086956522 25.2 25 2 hypotension 0.0290904342845231 0.137571207761884 1.7179393496529 0.347826086956522 25.2 25 2 abnormal cardiovascular development 0.0290904342845231 0.137571207761884 1.7179393496529 0.347826086956522 25.2 25 2 abnormal ulna morphology 0.0290904342845231 0.137571207761884 1.7179393496529 0.347826086956522 25.2 25 2 abnormal palatal shelf fusion at midline 0.0290904342845231 0.137571207761884 1.7179393496529 0.347826086956522 25.2 25 2 abnormal vertebral artery topology 0.0290904342845231 0.137571207761884 1.7179393496529 0.347826086956522 25.2 25 2 abnormal bone mineralization 1.45488883743984e-06 6.3491859353186e-05 1.71438988818668 0.347107438016529 25.2 25 2 polydactyly 1.41534510486142e-05 0.000436283269299408 1.71355685131195 0.346938775510204 25.2 25 2 increased circulating LDL cholesterol level 0.00189756807697484 0.0205673228386706 1.71355685131195 0.346938775510204 25.2 25 2 increased T cell derived lymphoma incidence 0.00189756807697484 0.0205673228386706 1.71355685131195 0.346938775510204 25.2 25 2 decreased circulating creatinine level 0.00189756807697484 0.0205673228386706 1.71355685131195 0.346938775510204 25.2 25 2 increased urine protein level 0.000108757305926669 0.00218172418139185 1.7096800258565 0.346153846153846 25.2 25 2 thick skin 0.02182156270802 0.1172378774 1.7096800258565 0.346153846153846 25.2 25 2 decreased Peyer's patch number 0.02182156270802 0.1172378774 1.7096800258565 0.346153846153846 25.2 25 2 abnormal skeleton development 8.408689192612e-05 0.00176210208709525 1.70733478576616 0.345679012345679 25.2 25 2 reduced female fertility 5.07785851294813e-11 8.71115382824723e-09 1.70312952767314 0.344827586206897 25.2 25 2 abnormal parietal bone morphology 0.0164369064424023 0.0957664941232414 1.70312952767314 0.344827586206897 25.2 25 2 abnormal circulating glucose level 0.0164369064424023 0.0957664941232414 1.70312952767314 0.344827586206897 25.2 25 2 abnormal spinal nerve morphology 0.0164369064424023 0.0957664941232414 1.70312952767314 0.344827586206897 25.2 25 2 polychromatophilia 0.0164369064424023 0.0957664941232414 1.70312952767314 0.344827586206897 25.2 25 2 decreased B cell number 6.14573688613259e-10 8.73572600243132e-08 1.7023027657665 0.344660194174757 25.2 25 2 abnormal lung morphology 2.39531033719751e-06 9.84848671698978e-05 1.70169832638938 0.34453781512605 25.2 25 2 oxidative stress 3.89497285233094e-05 0.00095785863886405 1.70123716153128 0.344444444444444 25.2 25 2 retinal degeneration 2.3355907113819e-05 0.000660202488018463 1.69780724789916 0.34375 25.2 25 2 polydipsia 0.0124233525746983 0.0806709359971965 1.69780724789916 0.34375 25.2 25 2 failure of primitive streak formation 0.0124233525746983 0.0806709359971965 1.69780724789916 0.34375 25.2 25 2 abnormal diaphragm morphology 0.0124233525746983 0.0806709359971965 1.69780724789916 0.34375 25.2 25 2 bradykinesia 0.0124233525746983 0.0806709359971965 1.69780724789916 0.34375 25.2 25 2 increased circulating serum albumin level 0.00941682351306232 0.0640009521550342 1.69339735894358 0.342857142857143 25.2 25 2 abnormal embryonic epiblast morphology 0.00941682351306232 0.0640009521550342 1.69339735894358 0.342857142857143 25.2 25 2 decreased bone marrow cell number 0.000233141592541358 0.00398583994121394 1.69146425693565 0.342465753424658 25.2 25 2 abnormal frontal bone morphology 0.00715537741329236 0.0534504544010954 1.68968376824414 0.342105263157895 25.2 25 2 abnormal compact bone morphology 0.00715537741329236 0.0534504544010954 1.68968376824414 0.342105263157895 25.2 25 2 abnormal developmental patterning 0.000107343841286591 0.00216208749150117 1.68651362984218 0.341463414634146 25.2 25 2 short ulna 0.00544850025838774 0.0437904503804184 1.68651362984218 0.341463414634146 25.2 25 2 abnormal cholesterol homeostasis 0.00544850025838774 0.0437904503804184 1.68651362984218 0.341463414634146 25.2 25 2 hyperglycemia 6.41502546152216e-05 0.00142054133538522 1.68377578304049 0.340909090909091 25.2 25 2 decreased blood urea nitrogen level 0.00415642312219123 0.0374917990130405 1.68377578304049 0.340909090909091 25.2 25 2 small spleen 4.96208959944897e-05 0.00116997136290325 1.6825422476683 0.340659340659341 25.2 25 2 preweaning lethality, complete penetrance 1.04565337054696e-30 1.66965068154669e-27 1.68195548489666 0.340540540540541 25.2 25 2 decreased cell proliferation 9.37276940602962e-09 7.90330979576227e-07 1.68195548489666 0.340540540540541 25.2 25 2 abnormal tibia morphology 0.00317588090332841 0.030739314190776 1.68138744859646 0.340425531914894 25.2 25 2 pulmonary hypoplasia 0.00317588090332841 0.030739314190776 1.68138744859646 0.340425531914894 25.2 25 2 increased circulating free fatty acid level 0.000384414609477308 0.00591961821119974 1.6695466919162 0.338028169014085 25.2 25 2 obese 0.000228557629434752 0.003920945539441 1.66773982320201 0.337662337662338 25.2 25 2 abnormal retinal pigment epithelium morphology 0.000176386503442557 0.00320846289209536 1.66693802521008 0.3375 25.2 25 2 short tail 0.000136194098775969 0.00259634698290432 1.66619418851878 0.337349397590361 25.2 25 2 abnormal cranium morphology 1.76948883506542e-06 7.46034487665295e-05 1.65864480120406 0.335820895522388 25.2 25 2 increased insulin sensitivity 8.27735777524676e-07 4.0372406795934e-05 1.65787154022448 0.335664335664336 25.2 25 2 impaired glucose tolerance 1.23942132188489e-10 1.92691283636792e-08 1.65299708593115 0.334677419354839 25.2 25 2 microphthalmia 4.87012602116449e-07 2.6335735820971e-05 1.64635854341737 0.333333333333333 25.2 25 2 incomplete embryo turning 0.00180846395011228 0.0197738640699089 1.64635854341737 0.333333333333333 25.2 25 2 abnormal craniofacial bone morphology 0.00180846395011228 0.0197738640699089 1.64635854341737 0.333333333333333 25.2 25 2 abnormal autopod morphology 0.00527984631171172 0.042780513682029 1.64635854341737 0.333333333333333 25.2 25 2 small placenta 0.00527984631171172 0.042780513682029 1.64635854341737 0.333333333333333 25.2 25 2 abnormal ovarian folliculogenesis 0.0158600803922253 0.0957664941232414 1.64635854341737 0.333333333333333 25.2 25 2 decreased systemic arterial blood pressure 0.0158600803922253 0.0957664941232414 1.64635854341737 0.333333333333333 25.2 25 2 abnormal locomotor coordination 0.0158600803922253 0.0957664941232414 1.64635854341737 0.333333333333333 25.2 25 2 increased mean corpuscular hemoglobin 4.7388403645184e-05 0.00112802539777412 1.64635854341737 0.333333333333333 25.2 25 2 hypoglycemia 7.92222743237439e-05 0.00167004582525689 1.64635854341737 0.333333333333333 25.2 25 2 decreased heart weight 0.000222536309200774 0.00385594632967696 1.64635854341737 0.333333333333333 25.2 25 2 spleen hyperplasia 0.000374124404448562 0.00583469878411159 1.64635854341737 0.333333333333333 25.2 25 2 abnormal coat appearance 0.000630562078877961 0.00881192792814004 1.64635854341737 0.333333333333333 25.2 25 2 abnormal mandible morphology 0.00235929913961222 0.0241512617686642 1.64635854341737 0.333333333333333 25.2 25 2 neurodegeneration 0.00235929913961222 0.0241512617686642 1.64635854341737 0.333333333333333 25.2 25 2 abnormal osteoblast physiology 0.00235929913961222 0.0241512617686642 1.64635854341737 0.333333333333333 25.2 25 2 abnormal kidney physiology 0.00403061257286801 0.0365251321493959 1.64635854341737 0.333333333333333 25.2 25 2 thymus atrophy 0.00403061257286801 0.0365251321493959 1.64635854341737 0.333333333333333 25.2 25 2 disheveled coat 0.00692821027687832 0.052783837867488 1.64635854341737 0.333333333333333 25.2 25 2 skin edema 0.00692821027687832 0.052783837867488 1.64635854341737 0.333333333333333 25.2 25 2 abnormal reproductive system morphology 0.00692821027687832 0.052783837867488 1.64635854341737 0.333333333333333 25.2 25 2 abnormal spleen white pulp morphology 0.00692821027687832 0.052783837867488 1.64635854341737 0.333333333333333 25.2 25 2 abnormal cytotoxic T cell physiology 0.00692821027687832 0.052783837867488 1.64635854341737 0.333333333333333 25.2 25 2 renal hypoplasia 0.0120037575616075 0.0785772287749966 1.64635854341737 0.333333333333333 25.2 25 2 increased metastatic potential 0.0210206534563913 0.114167850377234 1.64635854341737 0.333333333333333 25.2 25 2 disorganized myocardium 0.0210206534563913 0.114167850377234 1.64635854341737 0.333333333333333 25.2 25 2 enhanced paired-pulse facilitation 0.0210206534563913 0.114167850377234 1.64635854341737 0.333333333333333 25.2 25 2 rectal prolapse 0.0279644273674073 0.136466118016056 1.64635854341737 0.333333333333333 25.2 25 2 abnormal trigeminal nerve morphology 0.0279644273674073 0.136466118016056 1.64635854341737 0.333333333333333 25.2 25 2 abnormal brain commissure morphology 0.0279644273674073 0.136466118016056 1.64635854341737 0.333333333333333 25.2 25 2 abnormal type II pneumocyte morphology 0.0279644273674073 0.136466118016056 1.64635854341737 0.333333333333333 25.2 25 2 abnormal eye muscle morphology 0.0279644273674073 0.136466118016056 1.64635854341737 0.333333333333333 25.2 25 2 abnormal palate morphology 0.0279644273674073 0.136466118016056 1.64635854341737 0.333333333333333 25.2 25 2 abnormal digestive system morphology 0.03737136793516 0.162236086804032 1.64635854341737 0.333333333333333 25.2 25 2 abnormal body weight 0.03737136793516 0.162236086804032 1.64635854341737 0.333333333333333 25.2 25 2 abnormal cardiac muscle contractility 0.03737136793516 0.162236086804032 1.64635854341737 0.333333333333333 25.2 25 2 abnormal osteoblast morphology 0.03737136793516 0.162236086804032 1.64635854341737 0.333333333333333 25.2 25 2 hypopigmentation 0.03737136793516 0.162236086804032 1.64635854341737 0.333333333333333 25.2 25 2 abnormal cellular extravasation 0.03737136793516 0.162236086804032 1.64635854341737 0.333333333333333 25.2 25 2 abnormal truncus arteriosus septation 0.03737136793516 0.162236086804032 1.64635854341737 0.333333333333333 25.2 25 2 abnormal salivary gland morphology 0.0502265013691494 0.202986875963865 1.64635854341737 0.333333333333333 25.2 25 2 increased vasoconstriction 0.0502265013691494 0.202986875963865 1.64635854341737 0.333333333333333 25.2 25 2 abnormal embryonic/fetal subventricular zone morphology 0.0502265013691494 0.202986875963865 1.64635854341737 0.333333333333333 25.2 25 2 abnormal megakaryocyte differentiation 0.0679964714853434 0.251137673080611 1.64635854341737 0.333333333333333 25.2 25 2 underdeveloped hair follicles 0.0679964714853434 0.251137673080611 1.64635854341737 0.333333333333333 25.2 25 2 abnormal phrenic nerve morphology 0.0679964714853434 0.251137673080611 1.64635854341737 0.333333333333333 25.2 25 2 abnormal Peyer's patch follicle morphology 0.0679964714853434 0.251137673080611 1.64635854341737 0.333333333333333 25.2 25 2 decreased cellular sensitivity to gamma-irradiation 0.0679964714853434 0.251137673080611 1.64635854341737 0.333333333333333 25.2 25 2 abnormal body wall morphology 0.0679964714853434 0.251137673080611 1.64635854341737 0.333333333333333 25.2 25 2 jerky movement 0.0679964714853434 0.251137673080611 1.64635854341737 0.333333333333333 25.2 25 2 abnormal glycogen homeostasis 0.0679964714853434 0.251137673080611 1.64635854341737 0.333333333333333 25.2 25 2 decreased tumor latency 0.0679964714853434 0.251137673080611 1.64635854341737 0.333333333333333 25.2 25 2 increased effector memory CD8-positive, alpha-beta T cell number 0.0679964714853434 0.251137673080611 1.64635854341737 0.333333333333333 25.2 25 2 abnormal metanephric mesenchyme morphology 0.0679964714853434 0.251137673080611 1.64635854341737 0.333333333333333 25.2 25 2 abnormal hypoglossal nerve topology 0.0679964714853434 0.251137673080611 1.64635854341737 0.333333333333333 25.2 25 2 increased adipocyte glucose uptake 0.0679964714853434 0.251137673080611 1.64635854341737 0.333333333333333 25.2 25 2 abnormal fontanelle morphology 0.0929513241505847 0.306044234049741 1.64635854341737 0.333333333333333 25.2 25 2 absent incisors 0.0929513241505847 0.306044234049741 1.64635854341737 0.333333333333333 25.2 25 2 abnormal enteric neuron morphology 0.0929513241505847 0.306044234049741 1.64635854341737 0.333333333333333 25.2 25 2 abnormal bronchus morphology 0.0929513241505847 0.306044234049741 1.64635854341737 0.333333333333333 25.2 25 2 increased alcohol consumption 0.0929513241505847 0.306044234049741 1.64635854341737 0.333333333333333 25.2 25 2 abnormal glial cell morphology 0.0929513241505847 0.306044234049741 1.64635854341737 0.333333333333333 25.2 25 2 abnormal energy homeostasis 0.0929513241505847 0.306044234049741 1.64635854341737 0.333333333333333 25.2 25 2 ostium primum atrial septal defect 0.0929513241505847 0.306044234049741 1.64635854341737 0.333333333333333 25.2 25 2 abnormal branching involved in lung morphogenesis 0.0929513241505847 0.306044234049741 1.64635854341737 0.333333333333333 25.2 25 2 decreased brown adipose tissue mass 0.0929513241505847 0.306044234049741 1.64635854341737 0.333333333333333 25.2 25 2 decreased susceptibility to hepatic steatosis 0.00106595535993355 0.0131265542467064 1.64635854341737 0.333333333333333 25.2 25 2 abnormal glucose homeostasis 7.8611496876908e-08 5.35742735565229e-06 1.6282666912919 0.32967032967033 25.2 25 2 abnormal liver morphology 1.01130629633296e-07 6.59320764716495e-06 1.62796347589315 0.329608938547486 25.2 25 2 small kidney 0.000166325785060046 0.00307609955640792 1.62764992360581 0.329545454545455 25.2 25 2 cardiac fibrosis 0.000215396466288521 0.00374684412512375 1.62698961937716 0.329411764705882 25.2 25 2 hunched posture 0.000361803047164817 0.00570489564537212 1.62551856185512 0.329113924050633 25.2 25 2 abnormal visceral yolk sac morphology 0.000361803047164817 0.00570489564537212 1.62551856185512 0.329113924050633 25.2 25 2 abnormal nervous system morphology 0.000361803047164817 0.00570489564537212 1.62551856185512 0.329113924050633 25.2 25 2 increased sacral vertebrae number 0.00133800884271965 0.0157539409390966 1.62063419117647 0.328125 25.2 25 2 abnormal embryonic neuroepithelium morphology 0.00227089953437794 0.0236170246659665 1.61797305128948 0.327586206896552 25.2 25 2 abnormal neural tube morphology 5.71583132833684e-07 3.03360271628051e-05 1.61587042224297 0.327160493827161 25.2 25 2 eyelids open at birth 0.00387138124752814 0.0354698373967818 1.6146978021978 0.326923076923077 25.2 25 2 abnormal hair growth 0.00387138124752814 0.0354698373967818 1.6146978021978 0.326923076923077 25.2 25 2 increased susceptibility to injury 0.00387138124752814 0.0354698373967818 1.6146978021978 0.326923076923077 25.2 25 2 increased sarcoma incidence 0.00506481596481621 0.0413751386288352 1.61275938947007 0.326530612244898 25.2 25 2 abnormal bone structure 5.71523056161669e-08 4.06189600629186e-06 1.61223712282841 0.326424870466321 25.2 25 2 premature death 1.34243270878126e-30 1.66965068154669e-27 1.61193989791038 0.326364692218351 25.2 25 2 abnormal immune system morphology 0.00663639514414864 0.0509507188921905 1.6105681402996 0.326086956521739 25.2 25 2 abnormal allantois morphology 0.00663639514414864 0.0509507188921905 1.6105681402996 0.326086956521739 25.2 25 2 increased startle reflex 0.00020741608511018 0.00367222428264464 1.60936172221698 0.325842696629214 25.2 25 2 postnatal lethality, incomplete penetrance 1.92724097128221e-20 9.58802383212902e-18 1.60867780210676 0.325704225352113 25.2 25 2 impaired macrophage phagocytosis 0.00871084145808514 0.0624444326426132 1.60807113543092 0.325581395348837 25.2 25 2 abnormal blood circulation 0.00871084145808514 0.0624444326426132 1.60807113543092 0.325581395348837 25.2 25 2 abnormal double-strand DNA break repair 0.00871084145808514 0.0624444326426132 1.60807113543092 0.325581395348837 25.2 25 2 abnormal neural tube closure 0.000347979329680163 0.0055487088626885 1.60668725321454 0.325301204819277 25.2 25 2 abnormal enzyme/coenzyme activity 1.17500360094941e-06 5.36297515112231e-05 1.60441310282075 0.32484076433121 25.2 25 2 small seminiferous tubules 0.000759322464056473 0.0100736780231492 1.60186236656825 0.324324324324324 25.2 25 2 decreased circulating chloride level 0.0151023622483099 0.0941531982272451 1.60186236656825 0.324324324324324 25.2 25 2 increased leukocyte cell number 3.22945680266985e-06 0.000119899608905093 1.60094175601275 0.324137931034483 25.2 25 2 thrombocytopenia 3.22945680266985e-06 0.000119899608905093 1.60094175601275 0.324137931034483 25.2 25 2 increased circulating HDL cholesterol level 7.1188526099989e-05 0.0015265642989114 1.59931972789116 0.323809523809524 25.2 25 2 respiratory distress 4.12089230311507e-07 2.2779376897775e-05 1.59877592655559 0.323699421965318 25.2 25 2 abnormal retinal photoreceptor morphology 0.0199615730121857 0.109178563013025 1.59793623331686 0.323529411764706 25.2 25 2 lung hemorrhage 0.0199615730121857 0.109178563013025 1.59793623331686 0.323529411764706 25.2 25 2 abnormal bone remodeling 0.0199615730121857 0.109178563013025 1.59793623331686 0.323529411764706 25.2 25 2 increased susceptibility to viral infection induced morbidity/mortality 0.0199615730121857 0.109178563013025 1.59793623331686 0.323529411764706 25.2 25 2 enlarged heart 5.32754574763996e-09 4.81900728991069e-07 1.59668393219357 0.323275862068966 25.2 25 2 prenatal lethality 0.00217058599766141 0.0227819943847373 1.59325020330713 0.32258064516129 25.2 25 2 abnormal postnatal growth/weight/body size 0.0264672557129379 0.136466118016056 1.59325020330713 0.32258064516129 25.2 25 2 decreased thymus weight 0.0264672557129379 0.136466118016056 1.59325020330713 0.32258064516129 25.2 25 2 abnormal podocyte morphology 0.0264672557129379 0.136466118016056 1.59325020330713 0.32258064516129 25.2 25 2 decreased body size 4.28359751271607e-27 3.04441394653749e-24 1.5906546829258 0.322055137844612 25.2 25 2 abnormal thoracic vertebrae morphology 0.0028287122872126 0.0279223087874656 1.59054977923373 0.322033898305085 25.2 25 2 increased B cell proliferation 0.0028287122872126 0.0279223087874656 1.59054977923373 0.322033898305085 25.2 25 2 abnormal jaw morphology 0.0352250947569801 0.15844922822421 1.5875600240096 0.321428571428571 25.2 25 2 increased circulating alkaline phosphatase level 1.39285684484032e-06 6.24275928205461e-05 1.58538230106858 0.320987654320988 25.2 25 2 increased neuron apoptosis 0.000559115417932692 0.00794742629775756 1.58538230106858 0.320987654320988 25.2 25 2 embryonic lethality before implantation, complete penetrance 2.35093762830946e-05 0.000660749621026829 1.58050420168067 0.32 25.2 25 2 mandible hypoplasia 0.0470950204167157 0.196558495447282 1.58050420168067 0.32 25.2 25 2 abnormal thyroid gland morphology 0.0470950204167157 0.196558495447282 1.58050420168067 0.32 25.2 25 2 abnormal egg cylinder morphology 0.0470950204167157 0.196558495447282 1.58050420168067 0.32 25.2 25 2 abnormal feces composition 0.0470950204167157 0.196558495447282 1.58050420168067 0.32 25.2 25 2 increased cellular sensitivity to ionizing radiation 0.0470950204167157 0.196558495447282 1.58050420168067 0.32 25.2 25 2 decreased placenta weight 0.0470950204167157 0.196558495447282 1.58050420168067 0.32 25.2 25 2 abnormal vertebrae development 0.0470950204167157 0.196558495447282 1.58050420168067 0.32 25.2 25 2 abnormal energy expenditure 0.0470950204167157 0.196558495447282 1.58050420168067 0.32 25.2 25 2 abnormal preimplantation embryo development 0.0470950204167157 0.196558495447282 1.58050420168067 0.32 25.2 25 2 abnormal trabecular bone morphology 3.90844831536487e-05 0.00095785863886405 1.57718381470235 0.319327731092437 25.2 25 2 abnormal T-helper 1 physiology 0.00825851119453306 0.0602334748535315 1.57630073305918 0.319148936170213 25.2 25 2 decreased bone trabecula number 0.00825851119453306 0.0602334748535315 1.57630073305918 0.319148936170213 25.2 25 2 increased spleen weight 6.503626344687e-05 0.00142054133538522 1.57351082025731 0.31858407079646 25.2 25 2 osteoporosis 0.0108362366815024 0.0718065925780727 1.57152406417112 0.318181818181818 25.2 25 2 hypertension 0.0108362366815024 0.0718065925780727 1.57152406417112 0.318181818181818 25.2 25 2 abnormal abdominal fat pad morphology 0.0633221220263503 0.240401252243741 1.57152406417112 0.318181818181818 25.2 25 2 increased activated T cell number 0.0633221220263503 0.240401252243741 1.57152406417112 0.318181818181818 25.2 25 2 abnormal chorion morphology 0.0633221220263503 0.240401252243741 1.57152406417112 0.318181818181818 25.2 25 2 abnormal lysosome physiology 0.0633221220263503 0.240401252243741 1.57152406417112 0.318181818181818 25.2 25 2 decreased cardiac output 0.0633221220263503 0.240401252243741 1.57152406417112 0.318181818181818 25.2 25 2 abnormal female reproductive system physiology 0.0633221220263503 0.240401252243741 1.57152406417112 0.318181818181818 25.2 25 2 abnormal blood-brain barrier function 0.0633221220263503 0.240401252243741 1.57152406417112 0.318181818181818 25.2 25 2 increased mammary gland tumor incidence 0.0633221220263503 0.240401252243741 1.57152406417112 0.318181818181818 25.2 25 2 increased bone volume 0.0633221220263503 0.240401252243741 1.57152406417112 0.318181818181818 25.2 25 2 decreased body length 9.14303484557854e-10 1.13716495891883e-07 1.56824664172238 0.317518248175182 25.2 25 2 Leydig cell hyperplasia 0.0142460111474063 0.0891495666142721 1.56604837056774 0.317073170731707 25.2 25 2 liver fibrosis 0.0142460111474063 0.0891495666142721 1.56604837056774 0.317073170731707 25.2 25 2 palatal shelves fail to meet at midline 0.0142460111474063 0.0891495666142721 1.56604837056774 0.317073170731707 25.2 25 2 increased bone trabecula number 0.0142460111474063 0.0891495666142721 1.56604837056774 0.317073170731707 25.2 25 2 postnatal growth retardation 6.81019410721012e-20 3.08006506212458e-17 1.56565469324985 0.316993464052288 25.2 25 2 abnormal pulmonary alveolus morphology 0.00018064348231013 0.00324440911369278 1.56485564522839 0.316831683168317 25.2 25 2 abnormal brain morphology 2.70149725044214e-06 0.000109267876593086 1.56455190771961 0.316770186335404 25.2 25 2 abnormal eating behavior 0.00349647658195438 0.0325748520509794 1.5640406162465 0.316666666666667 25.2 25 2 abnormal myocardium layer morphology 0.000893102488969309 0.0113927817503136 1.56299861716839 0.316455696202532 25.2 25 2 abnormal axial skeleton morphology 0.00115810518298802 0.0140526177691839 1.55970809376382 0.315789473684211 25.2 25 2 enlarged adrenal glands 0.0857572818291855 0.285379583344614 1.55970809376382 0.315789473684211 25.2 25 2 flaky skin 0.0857572818291855 0.285379583344614 1.55970809376382 0.315789473684211 25.2 25 2 unresponsive to tactile stimuli 0.0857572818291855 0.285379583344614 1.55970809376382 0.315789473684211 25.2 25 2 delayed sexual maturation 0.0857572818291855 0.285379583344614 1.55970809376382 0.315789473684211 25.2 25 2 abnormal nasal septum morphology 0.0857572818291855 0.285379583344614 1.55970809376382 0.315789473684211 25.2 25 2 abnormal metatarsal bone morphology 0.0857572818291855 0.285379583344614 1.55970809376382 0.315789473684211 25.2 25 2 increased liver adenoma incidence 0.0857572818291855 0.285379583344614 1.55970809376382 0.315789473684211 25.2 25 2 osteoarthritis 0.0857572818291855 0.285379583344614 1.55970809376382 0.315789473684211 25.2 25 2 absent amnion 0.0857572818291855 0.285379583344614 1.55970809376382 0.315789473684211 25.2 25 2 decreased eye pigmentation 0.0857572818291855 0.285379583344614 1.55970809376382 0.315789473684211 25.2 25 2 decreased liver regeneration 0.0857572818291855 0.285379583344614 1.55970809376382 0.315789473684211 25.2 25 2 Leydig cell hypoplasia 0.0857572818291855 0.285379583344614 1.55970809376382 0.315789473684211 25.2 25 2 increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 0.0857572818291855 0.285379583344614 1.55970809376382 0.315789473684211 25.2 25 2 neonatal lethality, incomplete penetrance 3.88437702837025e-09 3.8649551432284e-07 1.55770846800259 0.315384615384615 25.2 25 2 decreased IgG level 0.000102918514985778 0.00208987596756835 1.55736618971913 0.315315315315315 25.2 25 2 increased sensitivity to induced morbidity/mortality 6.97637009024478e-07 3.50580214130988e-05 1.55688253562294 0.315217391304348 25.2 25 2 seminiferous tubule degeneration 0.00150266049341009 0.0171069472647945 1.5561471163808 0.315068493150685 25.2 25 2 increased tumor incidence 4.55740492420448e-05 0.00109005237970756 1.55341894822445 0.314516129032258 25.2 25 2 decreased bone mineralization 0.024794583199284 0.130809174354653 1.55228091236495 0.314285714285714 25.2 25 2 impaired hematopoiesis 0.00777804757154052 0.0570734316643276 1.54951392321635 0.313725490196078 25.2 25 2 abnormal cervical vertebrae morphology 0.00777804757154052 0.0570734316643276 1.54951392321635 0.313725490196078 25.2 25 2 abnormal thrombosis 0.00777804757154052 0.0570734316643276 1.54951392321635 0.313725490196078 25.2 25 2 limb grasping 1.09234854353872e-06 5.12682453217466e-05 1.54685335672731 0.313186813186813 25.2 25 2 abnormal neuron morphology 0.000285577698057173 0.00468894075192882 1.54657923775571 0.313131313131313 25.2 25 2 cyanosis 6.28459449497289e-07 3.22328428994744e-05 1.54346113445378 0.3125 25.2 25 2 scoliosis 0.0328508480485014 0.148710617871969 1.54346113445378 0.3125 25.2 25 2 abnormal tympanic ring morphology 0.117254474818171 0.360087044580494 1.54346113445378 0.3125 25.2 25 2 absent mandible 0.117254474818171 0.360087044580494 1.54346113445378 0.3125 25.2 25 2 abnormal mouth morphology 0.117254474818171 0.360087044580494 1.54346113445378 0.3125 25.2 25 2 poor circulation 0.117254474818171 0.360087044580494 1.54346113445378 0.3125 25.2 25 2 increased intestinal adenocarcinoma incidence 0.117254474818171 0.360087044580494 1.54346113445378 0.3125 25.2 25 2 small pancreas 0.117254474818171 0.360087044580494 1.54346113445378 0.3125 25.2 25 2 small epididymis 0.117254474818171 0.360087044580494 1.54346113445378 0.3125 25.2 25 2 abnormal amnion morphology 0.117254474818171 0.360087044580494 1.54346113445378 0.3125 25.2 25 2 dystonia 0.117254474818171 0.360087044580494 1.54346113445378 0.3125 25.2 25 2 decreased creatinine clearance 0.117254474818171 0.360087044580494 1.54346113445378 0.3125 25.2 25 2 kidney degeneration 0.117254474818171 0.360087044580494 1.54346113445378 0.3125 25.2 25 2 abnormal thoracic cage shape 0.117254474818171 0.360087044580494 1.54346113445378 0.3125 25.2 25 2 decreased skeletal muscle weight 0.117254474818171 0.360087044580494 1.54346113445378 0.3125 25.2 25 2 decreased body weight 7.74289818974267e-37 3.85209184939698e-33 1.53997026920623 0.311793214862682 25.2 25 2 abnormal maternal nurturing 0.00429005374553183 0.0381839502114618 1.5384006061441 0.311475409836066 25.2 25 2 decreased total body fat amount 7.89656418727459e-11 1.30951356105637e-08 1.53791576510844 0.311377245508982 25.2 25 2 abnormal cartilage development 0.0133455742678594 0.0840433316235453 1.53660130718954 0.311111111111111 25.2 25 2 abnormal ectoderm development 0.0133455742678594 0.0840433316235453 1.53660130718954 0.311111111111111 25.2 25 2 lordosis 0.0436797794985403 0.184002458090803 1.53281657490582 0.310344827586207 25.2 25 2 aphagia 0.0436797794985403 0.184002458090803 1.53281657490582 0.310344827586207 25.2 25 2 decreased bone strength 0.0436797794985403 0.184002458090803 1.53281657490582 0.310344827586207 25.2 25 2 increased circulating triglyceride level 1.81268840977882e-05 0.000530477931685273 1.53281657490582 0.310344827586207 25.2 25 2 short limbs 0.000796336121833624 0.0105086795918363 1.53281657490582 0.310344827586207 25.2 25 2 increased monocyte cell number 0.000347889898789474 0.0055487088626885 1.53111344537815 0.31 25.2 25 2 decreased inflammatory response 0.00103001223311108 0.0129729388853864 1.52876150460184 0.30952380952381 25.2 25 2 abnormal muscle morphology 0.0175264046410913 0.100222831137275 1.52876150460184 0.30952380952381 25.2 25 2 abnormal retina morphology 3.23511187992809e-07 1.82894109120934e-05 1.52876150460184 0.30952380952381 25.2 25 2 abnormal behavior 4.62817398244288e-09 4.42791645435641e-07 1.52791548273986 0.309352517985612 25.2 25 2 reduced fertility 2.994563980357e-05 0.0007841029369619 1.52791548273986 0.309352517985612 25.2 25 2 increased heart weight 2.994563980357e-05 0.0007841029369619 1.52791548273986 0.309352517985612 25.2 25 2 abnormal embryo turning 0.0072877124126915 0.0540333371879884 1.52662337662338 0.309090909090909 25.2 25 2 abnormal embryo development 3.8493311284832e-05 0.00095785863886405 1.52530276816609 0.308823529411765 25.2 25 2 decreased mean corpuscular hemoglobin 0.00309496788542178 0.0300731742772917 1.52530276816609 0.308823529411765 25.2 25 2 weight loss 3.40130932530511e-06 0.000125344547358466 1.52405762304922 0.308571428571429 25.2 25 2 infertility 0.000253921626504964 0.00431146789031466 1.52326631587214 0.308411214953271 25.2 25 2 increased B cell number 0.000143965612566508 0.00269258993427962 1.51971557853911 0.307692307692308 25.2 25 2 absent corpus luteum 0.00951434371554602 0.0644875476632717 1.51971557853911 0.307692307692308 25.2 25 2 abnormal leukocyte migration 0.00951434371554602 0.0644875476632717 1.51971557853911 0.307692307692308 25.2 25 2 abnormal leukocyte adhesion 0.0230640156818163 0.122589185915637 1.51971557853911 0.307692307692308 25.2 25 2 failure of heart looping 0.0230640156818163 0.122589185915637 1.51971557853911 0.307692307692308 25.2 25 2 no spontaneous movement 0.0583276682872471 0.227770918154674 1.51971557853911 0.307692307692308 25.2 25 2 heart inflammation 0.0583276682872471 0.227770918154674 1.51971557853911 0.307692307692308 25.2 25 2 increased leukemia incidence 0.0583276682872471 0.227770918154674 1.51971557853911 0.307692307692308 25.2 25 2 pulmonary edema 0.0583276682872471 0.227770918154674 1.51971557853911 0.307692307692308 25.2 25 2 decreased bone resorption 0.0583276682872471 0.227770918154674 1.51971557853911 0.307692307692308 25.2 25 2 increased circulating insulin level 1.18122336451218e-05 0.000374304855952107 1.51259191176471 0.30625 25.2 25 2 absent kidney 0.0124371071175577 0.0806709359971965 1.51196192762819 0.306122448979592 25.2 25 2 abnormal respiratory system physiology 0.0124371071175577 0.0806709359971965 1.51196192762819 0.306122448979592 25.2 25 2 abnormal craniofacial development 0.0124371071175577 0.0806709359971965 1.51196192762819 0.306122448979592 25.2 25 2 decreased circulating cholesterol level 3.01707441962764e-06 0.000115602277262639 1.51141112182578 0.306010928961749 25.2 25 2 cataract 0.000135258233189307 0.00259634698290432 1.51029585387874 0.305785123966942 25.2 25 2 abnormal systemic arterial blood pressure 0.0304225464798617 0.141715513798981 1.50916199813259 0.305555555555556 25.2 25 2 impaired wound healing 0.0304225464798617 0.141715513798981 1.50916199813259 0.305555555555556 25.2 25 2 abnormal lysosome morphology 0.0304225464798617 0.141715513798981 1.50916199813259 0.305555555555556 25.2 25 2 sparse hair 0.00161514162684222 0.0181384415204064 1.50581574093052 0.304878048780488 25.2 25 2 abnormal response/metabolism to endogenous compounds 0.00161514162684222 0.0181384415204064 1.50581574093052 0.304878048780488 25.2 25 2 spleen hypoplasia 0.000395655474494515 0.00591961821119974 1.50524209683874 0.304761904761905 25.2 25 2 abnormal lymphocyte physiology 0.0162808401344829 0.0957664941232414 1.50319693094629 0.304347826086957 25.2 25 2 abnormal innervation pattern to muscle 0.0782984854133995 0.264270668203299 1.50319693094629 0.304347826086957 25.2 25 2 blistering 0.0782984854133995 0.264270668203299 1.50319693094629 0.304347826086957 25.2 25 2 abnormal postnatal growth 0.0782984854133995 0.264270668203299 1.50319693094629 0.304347826086957 25.2 25 2 increased susceptibility to age related obesity 0.0782984854133995 0.264270668203299 1.50319693094629 0.304347826086957 25.2 25 2 dilated heart 0.0782984854133995 0.264270668203299 1.50319693094629 0.304347826086957 25.2 25 2 abnormal B cell morphology 0.0782984854133995 0.264270668203299 1.50319693094629 0.304347826086957 25.2 25 2 abnormal regulatory T cell physiology 0.0782984854133995 0.264270668203299 1.50319693094629 0.304347826086957 25.2 25 2 kinked tail 0.000509621188308173 0.00734888525169032 1.50109161311583 0.303921568627451 25.2 25 2 decreased food intake 0.00208862813165654 0.0221083509680666 1.50047867248165 0.30379746835443 25.2 25 2 abnormal skin morphology 0.00487154065474682 0.039927371923172 1.49668958492488 0.303030303030303 25.2 25 2 decreased brown adipose tissue amount 0.0402381383338388 0.170515109208559 1.49668958492488 0.303030303030303 25.2 25 2 abnormal heart morphology 2.87887299592649e-07 1.64625208675107e-05 1.49668958492488 0.303030303030303 25.2 25 2 abnormal organ of Corti morphology 0.0213464820203939 0.115684910731438 1.49320891147157 0.302325581395349 25.2 25 2 kidney failure 0.0213464820203939 0.115684910731438 1.49320891147157 0.302325581395349 25.2 25 2 ataxia 1.82962729867679e-06 7.64907211001433e-05 1.49150303685831 0.301980198019802 25.2 25 2 abnormal placenta development 0.01154419358595 0.0763728232581131 1.49104169969875 0.30188679245283 25.2 25 2 decreased grip strength 7.68417412019031e-07 3.82287662479468e-05 1.48848854610337 0.301369863013699 25.2 25 2 lethargy 0.00109014072069302 0.0133582514419896 1.48703352308665 0.301075268817204 25.2 25 2 improved glucose tolerance 2.99140993946245e-06 0.000115602277262639 1.48676256216772 0.301020408163265 25.2 25 2 abnormal cardiovascular system physiology 0.00011101498967001 0.00221799318255905 1.48543627977507 0.300751879699248 25.2 25 2 decreased insulin secretion 0.00140513764702597 0.016181851374894 1.48172268907563 0.3 25.2 25 2 domed cranium 0.00452801302037143 0.0396394644785398 1.48172268907563 0.3 25.2 25 2 abnormal long bone epiphyseal plate morphology 0.00821612833246131 0.0601106447852868 1.48172268907563 0.3 25.2 25 2 decreased oocyte number 0.0150652958800494 0.0940399585988027 1.48172268907563 0.3 25.2 25 2 decreased circulating phosphate level 0.0280386410560469 0.136466118016056 1.48172268907563 0.3 25.2 25 2 abnormal female reproductive system morphology 0.0280386410560469 0.136466118016056 1.48172268907563 0.3 25.2 25 2 abnormal heart tube morphology 0.0533908335166041 0.211312169248294 1.48172268907563 0.3 25.2 25 2 gastrointestinal hemorrhage 0.0533908335166041 0.211312169248294 1.48172268907563 0.3 25.2 25 2 delayed eyelid opening 0.0533908335166041 0.211312169248294 1.48172268907563 0.3 25.2 25 2 abnormal spleen marginal zone morphology 0.0533908335166041 0.211312169248294 1.48172268907563 0.3 25.2 25 2 liver hemorrhage 0.0533908335166041 0.211312169248294 1.48172268907563 0.3 25.2 25 2 abnormal cell proliferation 0.105804693139852 0.329810995219775 1.48172268907563 0.3 25.2 25 2 waved hair 0.105804693139852 0.329810995219775 1.48172268907563 0.3 25.2 25 2 increased urine glucose level 0.105804693139852 0.329810995219775 1.48172268907563 0.3 25.2 25 2 abnormal lens epithelium morphology 0.105804693139852 0.329810995219775 1.48172268907563 0.3 25.2 25 2 absent placental labyrinth 0.105804693139852 0.329810995219775 1.48172268907563 0.3 25.2 25 2 decreased circulating VLDL cholesterol level 0.105804693139852 0.329810995219775 1.48172268907563 0.3 25.2 25 2 increased body weight 8.58836799477018e-07 4.14826512368754e-05 1.47731280012005 0.299107142857143 25.2 25 2 increased total body fat amount 0.00013280316643605 0.00258084278523182 1.47435093440361 0.298507462686567 25.2 25 2 abnormal femur morphology 0.00586581586004699 0.0457404920121219 1.47435093440361 0.298507462686567 25.2 25 2 cachexia 0.000734260160673714 0.00978584389583849 1.47222446670976 0.298076923076923 25.2 25 2 increased white adipose tissue amount 0.0369041628855182 0.161192458608826 1.46837383602089 0.297297297297297 25.2 25 2 decreased caudal vertebrae number 0.00760280916600533 0.056035519408706 1.46628807773109 0.296875 25.2 25 2 abnormal tooth morphology 0.00760280916600533 0.056035519408706 1.46628807773109 0.296875 25.2 25 2 polyphagia 0.0138992000153186 0.0874191151405942 1.46342981637099 0.296296296296296 25.2 25 2 increased brain weight 0.0711121907798114 0.256729213563399 1.46342981637099 0.296296296296296 25.2 25 2 abnormal skin appearance 0.0711121907798114 0.256729213563399 1.46342981637099 0.296296296296296 25.2 25 2 decreased circulating fructosamine level 0.0711121907798114 0.256729213563399 1.46342981637099 0.296296296296296 25.2 25 2 decreased bone ossification 0.0711121907798114 0.256729213563399 1.46342981637099 0.296296296296296 25.2 25 2 atelectasis 0.00542840394380111 0.0437703559488015 1.46085335542668 0.295774647887324 25.2 25 2 decreased macrophage cell number 0.0257540042592839 0.134013506780649 1.45927234530176 0.295454545454545 25.2 25 2 lethality, incomplete penetrance 0.0257540042592839 0.134013506780649 1.45927234530176 0.295454545454545 25.2 25 2 embryonic lethality, incomplete penetrance 0.0257540042592839 0.134013506780649 1.45927234530176 0.295454545454545 25.2 25 2 increased double-negative T cell number 0.00985960141536205 0.0661963792731798 1.45743215318914 0.295081967213115 25.2 25 2 abnormal NK cell physiology 0.00985960141536205 0.0661963792731798 1.45743215318914 0.295081967213115 25.2 25 2 absent gastric milk in neonates 0.00388622992705441 0.0355404299395141 1.45639409609998 0.294871794871795 25.2 25 2 alopecia 0.00155951714324711 0.0176733434798505 1.45572755417957 0.294736842105263 25.2 25 2 hypoactivity 7.55581661951965e-10 1.01595101843541e-07 1.45421059670553 0.294429708222812 25.2 25 2 increased lung adenocarcinoma incidence 0.0181016493419281 0.102015635587274 1.45266930301532 0.294117647058824 25.2 25 2 short maxilla 0.0486867072178609 0.201838788114126 1.45266930301532 0.294117647058824 25.2 25 2 overexpanded pulmonary alveoli 0.0486867072178609 0.201838788114126 1.45266930301532 0.294117647058824 25.2 25 2 abnormal vision 0.0486867072178609 0.201838788114126 1.45266930301532 0.294117647058824 25.2 25 2 abnormal spleen red pulp morphology 0.0486867072178609 0.201838788114126 1.45266930301532 0.294117647058824 25.2 25 2 decreased osteoblast cell number 0.0486867072178609 0.201838788114126 1.45266930301532 0.294117647058824 25.2 25 2 abnormal urinary bladder morphology 0.144204777675966 0.397241843265744 1.45266930301532 0.294117647058824 25.2 25 2 enlarged sebaceous gland 0.144204777675966 0.397241843265744 1.45266930301532 0.294117647058824 25.2 25 2 hyperlipidemia 0.144204777675966 0.397241843265744 1.45266930301532 0.294117647058824 25.2 25 2 increased regulatory T cell number 0.144204777675966 0.397241843265744 1.45266930301532 0.294117647058824 25.2 25 2 abnormal melanosome morphology 0.144204777675966 0.397241843265744 1.45266930301532 0.294117647058824 25.2 25 2 abnormal tarsal bone morphology 0.144204777675966 0.397241843265744 1.45266930301532 0.294117647058824 25.2 25 2 decreased growth hormone level 0.144204777675966 0.397241843265744 1.45266930301532 0.294117647058824 25.2 25 2 pancytopenia 0.144204777675966 0.397241843265744 1.45266930301532 0.294117647058824 25.2 25 2 increased circulating magnesium level 0.144204777675966 0.397241843265744 1.45266930301532 0.294117647058824 25.2 25 2 delayed heart development 0.144204777675966 0.397241843265744 1.45266930301532 0.294117647058824 25.2 25 2 increased bone mineral content 0.000812194052775048 0.0105994983719754 1.45000385475291 0.293577981651376 25.2 25 2 abnormal locomotor behavior 0.00200479197955605 0.0212661835784464 1.44951132626964 0.293478260869565 25.2 25 2 dermatitis 0.012793806362136 0.081706272980265 1.44766009852217 0.293103448275862 25.2 25 2 abnormal motor coordination/ balance 0.00144379628851887 0.0165886525066545 1.44679993209405 0.292929292929293 25.2 25 2 lethality at weaning, incomplete penetrance 0.0337459361906567 0.152485043186664 1.4455831112933 0.292682926829268 25.2 25 2 decreased leukocyte cell number 0.00022321860159738 0.00385594632967696 1.44206587744587 0.291970802919708 25.2 25 2 enlarged spleen 1.29320413480672e-07 7.94282786501657e-06 1.4405637254902 0.291666666666667 25.2 25 2 abnormal cardiovascular system morphology 0.0235976514601098 0.124759103096755 1.4405637254902 0.291666666666667 25.2 25 2 curly tail 0.0235976514601098 0.124759103096755 1.4405637254902 0.291666666666667 25.2 25 2 abnormal adrenal gland morphology 0.0951508279044394 0.310485728814704 1.4405637254902 0.291666666666667 25.2 25 2 decreased body height 0.0951508279044394 0.310485728814704 1.4405637254902 0.291666666666667 25.2 25 2 curly vibrissae 0.0951508279044394 0.310485728814704 1.4405637254902 0.291666666666667 25.2 25 2 abnormal startle reflex 0.0951508279044394 0.310485728814704 1.4405637254902 0.291666666666667 25.2 25 2 abnormal retinal ganglion layer morphology 0.0951508279044394 0.310485728814704 1.4405637254902 0.291666666666667 25.2 25 2 abnormal lung saccule morphology 0.0951508279044394 0.310485728814704 1.4405637254902 0.291666666666667 25.2 25 2 hyperactivity 2.55561711590087e-09 2.64879065658475e-07 1.43779021042379 0.291105121293801 25.2 25 2 increased circulating calcium level 0.0166116051856272 0.0957664941232414 1.43682200152788 0.290909090909091 25.2 25 2 abnormal contextual conditioning behavior 0.0166116051856272 0.0957664941232414 1.43682200152788 0.290909090909091 25.2 25 2 abnormal joint morphology 0.0166116051856272 0.0957664941232414 1.43682200152788 0.290909090909091 25.2 25 2 reduced male fertility 3.04399966259412e-06 0.000115602277262639 1.43603079998519 0.290748898678414 25.2 25 2 increased oxygen consumption 0.00331326789374391 0.0316990534064922 1.43577779949189 0.290697674418605 25.2 25 2 increased or absent threshold for auditory brainstem response 1.52472938345479e-07 9.25064473498487e-06 1.43557907592103 0.290657439446367 25.2 25 2 abnormal cranial ganglia morphology 0.0644050244362858 0.241458173753219 1.43392518297642 0.290322580645161 25.2 25 2 increased lung adenoma incidence 0.0644050244362858 0.241458173753219 1.43392518297642 0.290322580645161 25.2 25 2 inner cell mass degeneration 0.0644050244362858 0.241458173753219 1.43392518297642 0.290322580645161 25.2 25 2 abnormal T cell proliferation 0.0644050244362858 0.241458173753219 1.43392518297642 0.290322580645161 25.2 25 2 abnormal liver physiology 0.00171133240443901 0.0189197304712979 1.43233193277311 0.29 25.2 25 2 decreased heart rate 0.00171133240443901 0.0189197304712979 1.43233193277311 0.29 25.2 25 2 decreased spleen weight 0.00835316038531832 0.0603149098939893 1.43161612471075 0.289855072463768 25.2 25 2 increased circulating cholesterol level 4.18440306670014e-05 0.00101548318326016 1.43120941558442 0.289772727272727 25.2 25 2 increased T cell proliferation 0.00123307283752198 0.0146356565394677 1.43094714521323 0.289719626168224 25.2 25 2 azoospermia 0.000100815850169217 0.00205556907619612 1.4289149622113 0.289308176100629 25.2 25 2 abnormal metabolism 0.0307949289433002 0.143182029432634 1.42684407096172 0.288888888888889 25.2 25 2 lethality at weaning, complete penetrance 0.0307949289433002 0.143182029432634 1.42684407096172 0.288888888888889 25.2 25 2 decreased IgM level 0.00219347621319054 0.0229737771802588 1.42571255306246 0.288659793814433 25.2 25 2 preweaning lethality, incomplete penetrance 8.67675845678675e-10 1.13597035059248e-07 1.42496558525611 0.288508557457213 25.2 25 2 decreased cardiac muscle contractility 0.00157855728931131 0.0178079875608248 1.42473335488041 0.288461538461538 25.2 25 2 distended pericardium 0.0215829894607317 0.11683936079123 1.42473335488041 0.288461538461538 25.2 25 2 decreased litter size 3.66527564356274e-07 2.04884790187917e-05 1.42371930978797 0.288256227758007 25.2 25 2 syndactyly 0.0152197766105182 0.0947664438514747 1.42312348668281 0.288135593220339 25.2 25 2 abnormal seminiferous tubule morphology 0.00022537220971842 0.00387967731262679 1.42082997582595 0.287671232876712 25.2 25 2 abnormal posture 0.00547579017278993 0.0439388001768224 1.41998424369748 0.2875 25.2 25 2 abnormal nervous system physiology 0.00104901414427543 0.0129815065233546 1.41729996346365 0.28695652173913 25.2 25 2 abnormal midbrain development 0.0582435568252917 0.227770918154674 1.41116446578631 0.285714285714286 25.2 25 2 holoprosencephaly 0.0582435568252917 0.227770918154674 1.41116446578631 0.285714285714286 25.2 25 2 increased red blood cell distribution width 0.0582435568252917 0.227770918154674 1.41116446578631 0.285714285714286 25.2 25 2 abnormal cytokine secretion 0.000191999518985827 0.00343596261494421 1.41116446578631 0.285714285714286 25.2 25 2 cardiac hypertrophy 0.00258559436710721 0.0256241672835824 1.41116446578631 0.285714285714286 25.2 25 2 polyuria 0.00703921424151036 0.0528279071858305 1.41116446578631 0.285714285714286 25.2 25 2 abnormal long bone hypertrophic chondrocyte zone 0.0280618691971307 0.136466118016056 1.41116446578631 0.285714285714286 25.2 25 2 abnormal epidermis stratum corneum morphology 0.0280618691971307 0.136466118016056 1.41116446578631 0.285714285714286 25.2 25 2 abnormal optic nerve morphology 0.0402337488104829 0.170515109208559 1.41116446578631 0.285714285714286 25.2 25 2 abnormal circulating cholesterol level 0.0854670291889436 0.285379583344614 1.41116446578631 0.285714285714286 25.2 25 2 abnormal somite shape 0.0854670291889436 0.285379583344614 1.41116446578631 0.285714285714286 25.2 25 2 absent corpus callosum 0.0854670291889436 0.285379583344614 1.41116446578631 0.285714285714286 25.2 25 2 failure of blastocyst to hatch from the zona pellucida 0.0854670291889436 0.285379583344614 1.41116446578631 0.285714285714286 25.2 25 2 increased bone resorption 0.0854670291889436 0.285379583344614 1.41116446578631 0.285714285714286 25.2 25 2 increased incidence of induced tumors 0.128035969848133 0.38324923700859 1.41116446578631 0.285714285714286 25.2 25 2 abnormal stapes morphology 0.128035969848133 0.38324923700859 1.41116446578631 0.285714285714286 25.2 25 2 abnormal bile salt homeostasis 0.128035969848133 0.38324923700859 1.41116446578631 0.285714285714286 25.2 25 2 increased inflammatory response 0.00330800812359077 0.0316990534064922 1.40373728438744 0.284210526315789 25.2 25 2 short femur 0.00461450808954442 0.039828792403837 1.40314648586707 0.284090909090909 25.2 25 2 decreased compact bone thickness 0.0127318940757568 0.0814153894947173 1.40063338768343 0.283582089552239 25.2 25 2 liver inflammation 0.0011334860336519 0.0137875134900201 1.39940476190476 0.283333333333333 25.2 25 2 abnormal myelin sheath morphology 0.0365126002922282 0.159924730571877 1.39582572159299 0.282608695652174 25.2 25 2 small lens 0.0526316671124076 0.210653695803884 1.39307261366085 0.282051282051282 25.2 25 2 decreased B-1 B cell number 0.0526316671124076 0.210653695803884 1.39307261366085 0.282051282051282 25.2 25 2 increased sensitivity to xenobiotic induced morbidity/mortality 0.00200328599659516 0.0212661835784464 1.39192131398014 0.281818181818182 25.2 25 2 decreased circulating HDL cholesterol level 0.000956896501111378 0.0121753455064683 1.3891150210084 0.28125 25.2 25 2 decreased eosinophil cell number 0.0164019311065575 0.0957664941232414 1.3891150210084 0.28125 25.2 25 2 abnormal lymphatic vessel morphology 0.076752310848897 0.26028817073842 1.3891150210084 0.28125 25.2 25 2 neonatal lethality 0.076752310848897 0.26028817073842 1.3891150210084 0.28125 25.2 25 2 abnormal embryonic hematopoiesis 0.076752310848897 0.26028817073842 1.3891150210084 0.28125 25.2 25 2 increased macrophage cell number 0.0232386198856369 0.123385415081156 1.38640719445673 0.280701754385965 25.2 25 2 abnormal keratinocyte physiology 0.113839197482999 0.352426887042886 1.38294117647059 0.28 25.2 25 2 abnormal cochlear outer hair cell morphology 0.113839197482999 0.352426887042886 1.38294117647059 0.28 25.2 25 2 increased liver glycogen level 0.113839197482999 0.352426887042886 1.38294117647059 0.28 25.2 25 2 decreased susceptibility to injury 0.0149465799186011 0.0934161244912566 1.38003583786456 0.279411764705882 25.2 25 2 abnormal male reproductive system morphology 0.0475449488582593 0.19810395357608 1.37834668751221 0.27906976744186 25.2 25 2 abnormal axon guidance 0.0475449488582593 0.19810395357608 1.37834668751221 0.27906976744186 25.2 25 2 small testis 2.76160554775416e-06 0.000110511593011662 1.3779305200341 0.278985507246377 25.2 25 2 hydroencephaly 0.0021419117983313 0.0225285648978821 1.37435147972232 0.278260869565217 25.2 25 2 female infertility 4.76679198278876e-06 0.000169391357959815 1.37402855879194 0.278195488721804 25.2 25 2 diluted coat color 0.0300250843611761 0.140258023189531 1.37196545284781 0.277777777777778 25.2 25 2 abnormal small intestine morphology 0.0300250843611761 0.140258023189531 1.37196545284781 0.277777777777778 25.2 25 2 decreased platelet aggregation 0.0300250843611761 0.140258023189531 1.37196545284781 0.277777777777778 25.2 25 2 reduced long term depression 0.0689439454196878 0.254259546673793 1.37196545284781 0.277777777777778 25.2 25 2 abnormal limb bone morphology 0.0689439454196878 0.254259546673793 1.37196545284781 0.277777777777778 25.2 25 2 abnormal stomach glandular epithelium morphology 0.17351566467236 0.408537828558916 1.37196545284781 0.277777777777778 25.2 25 2 right pulmonary isomerism 0.17351566467236 0.408537828558916 1.37196545284781 0.277777777777778 25.2 25 2 abnormal radius morphology 0.17351566467236 0.408537828558916 1.37196545284781 0.277777777777778 25.2 25 2 absent spleen 0.17351566467236 0.408537828558916 1.37196545284781 0.277777777777778 25.2 25 2 blepharoptosis 0.17351566467236 0.408537828558916 1.37196545284781 0.277777777777778 25.2 25 2 abnormal iron level 0.17351566467236 0.408537828558916 1.37196545284781 0.277777777777778 25.2 25 2 eye inflammation 0.17351566467236 0.408537828558916 1.37196545284781 0.277777777777778 25.2 25 2 abnormal white adipose tissue morphology 0.17351566467236 0.408537828558916 1.37196545284781 0.277777777777778 25.2 25 2 absent ureter 0.17351566467236 0.408537828558916 1.37196545284781 0.277777777777778 25.2 25 2 atrioventricular block 0.17351566467236 0.408537828558916 1.37196545284781 0.277777777777778 25.2 25 2 abnormal macrophage chemotaxis 0.17351566467236 0.408537828558916 1.37196545284781 0.277777777777778 25.2 25 2 abnormal lipid level 0.00883648915316355 0.0630067511556245 1.36865951199757 0.27710843373494 25.2 25 2 decreased T cell proliferation 0.000621971721017047 0.0087163642593234 1.36825743811038 0.277027027027027 25.2 25 2 increased circulating glucose level 0.000858807389168606 0.011097576002893 1.36612730198462 0.276595744680851 25.2 25 2 hepatic necrosis 0.0429469685993599 0.181376204398825 1.36612730198462 0.276595744680851 25.2 25 2 abnormal innervation 0.0429469685993599 0.181376204398825 1.36612730198462 0.276595744680851 25.2 25 2 abnormal spermiogenesis 0.0272175964660183 0.136466118016056 1.36250362213851 0.275862068965517 25.2 25 2 abnormal middle ear morphology 0.101385981451955 0.318230446513233 1.36250362213851 0.275862068965517 25.2 25 2 decreased granulocyte number 0.101385981451955 0.318230446513233 1.36250362213851 0.275862068965517 25.2 25 2 absent long term depression 0.101385981451955 0.318230446513233 1.36250362213851 0.275862068965517 25.2 25 2 short sternum 0.101385981451955 0.318230446513233 1.36250362213851 0.275862068965517 25.2 25 2 increased retinal apoptosis 0.101385981451955 0.318230446513233 1.36250362213851 0.275862068965517 25.2 25 2 impaired ovarian folliculogenesis 0.0619600563061997 0.240401252243741 1.35824579831933 0.275 25.2 25 2 small ovary 0.00734513129354421 0.0543780181330096 1.35688890940992 0.274725274725275 25.2 25 2 impaired balance 0.00480461132246236 0.039828792403837 1.3558246828143 0.274509803921569 25.2 25 2 abnormal cued conditioning behavior 0.0387972326771743 0.166309349485744 1.3558246828143 0.274509803921569 25.2 25 2 abnormal gastrulation 0.0387972326771743 0.166309349485744 1.3558246828143 0.274509803921569 25.2 25 2 increased eosinophil cell number 0.0246709109164585 0.130294885147963 1.35426267281106 0.274193548387097 25.2 25 2 decreased startle reflex 0.00288161324550863 0.028388170091892 1.35085829203476 0.273504273504274 25.2 25 2 decreased circulating calcium level 0.035055139052007 0.15782743600338 1.34702062643239 0.272727272727273 25.2 25 2 abnormal rostral-caudal axis patterning 0.035055139052007 0.15782743600338 1.34702062643239 0.272727272727273 25.2 25 2 absent vibrissae 0.0904451255420439 0.299776482059739 1.34702062643239 0.272727272727273 25.2 25 2 abnormal T cell subpopulation ratio 0.0904451255420439 0.299776482059739 1.34702062643239 0.272727272727273 25.2 25 2 myeloid hyperplasia 0.0904451255420439 0.299776482059739 1.34702062643239 0.272727272727273 25.2 25 2 abnormal suckling behavior 0.00934843637294813 0.0637102341855027 1.34702062643239 0.272727272727273 25.2 25 2 abnormal myelopoiesis 0.055716553082875 0.219817487380891 1.34702062643239 0.272727272727273 25.2 25 2 abnormal long bone epiphysis morphology 0.152303662781301 0.39870178214528 1.34702062643239 0.272727272727273 25.2 25 2 abnormal facial nerve morphology 0.152303662781301 0.39870178214528 1.34702062643239 0.272727272727273 25.2 25 2 abnormal cochlear sensory epithelium morphology 0.152303662781301 0.39870178214528 1.34702062643239 0.272727272727273 25.2 25 2 abnormal sperm midpiece morphology 0.152303662781301 0.39870178214528 1.34702062643239 0.272727272727273 25.2 25 2 abnormal cerebral cortex pyramidal cell morphology 0.152303662781301 0.39870178214528 1.34702062643239 0.272727272727273 25.2 25 2 pulmonary vascular congestion 0.152303662781301 0.39870178214528 1.34702062643239 0.272727272727273 25.2 25 2 increased circulating creatine kinase level 0.152303662781301 0.39870178214528 1.34702062643239 0.272727272727273 25.2 25 2 postnatal lethality, complete penetrance 1.91370863633571e-07 1.13341672211549e-05 1.34353093569034 0.272020725388601 25.2 25 2 thick epidermis 0.0202718507175049 0.110583834780249 1.340606242497 0.271428571428571 25.2 25 2 increased hemoglobin content 0.0316819015285299 0.143722903039482 1.33941034040735 0.271186440677966 25.2 25 2 abnormal dendritic cell physiology 0.00506463051199119 0.0413751386288352 1.33862797455431 0.271028037383178 25.2 25 2 no abnormal phenotype detected 2.21785784552856e-28 2.20676855630091e-25 1.33796285084639 0.270893371757925 25.2 25 2 abnormal intestinal epithelium morphology 0.0501338578225099 0.202986875963865 1.33766631652661 0.270833333333333 25.2 25 2 abnormal lymph node morphology 0.0501338578225099 0.202986875963865 1.33766631652661 0.270833333333333 25.2 25 2 abnormal hair shaft morphology 0.0501338578225099 0.202986875963865 1.33766631652661 0.270833333333333 25.2 25 2 abnormal phalanx morphology 0.0501338578225099 0.202986875963865 1.33766631652661 0.270833333333333 25.2 25 2 male infertility 4.95883589829278e-09 4.65475633849181e-07 1.3354160749787 0.27037773359841 25.2 25 2 abnormal hepatocyte morphology 0.00461407127266743 0.039828792403837 1.33488530547354 0.27027027027027 25.2 25 2 abnormal intestine morphology 0.018378380239602 0.102502737322892 1.33488530547354 0.27027027027027 25.2 25 2 abnormal pancreatic beta cell physiology 0.0808105315434544 0.272195256891459 1.33488530547354 0.27027027027027 25.2 25 2 increased trabecular bone volume 0.0808105315434544 0.272195256891459 1.33488530547354 0.27027027027027 25.2 25 2 abnormal spleen morphology 0.000486502471655247 0.0070770461885522 1.33411813001062 0.270114942528736 25.2 25 2 neonatal lethality, complete penetrance 3.03760430650101e-08 2.22236491541802e-06 1.33225066342326 0.269736842105263 25.2 25 2 increased rib number 0.0166639585577084 0.0957664941232414 1.32975113122172 0.269230769230769 25.2 25 2 decreased IgA level 0.0451393222832322 0.189989956310558 1.32975113122172 0.269230769230769 25.2 25 2 abnormal leukocyte cell number 0.134290813502486 0.38324923700859 1.32975113122172 0.269230769230769 25.2 25 2 abnormal kidney cortex morphology 0.134290813502486 0.38324923700859 1.32975113122172 0.269230769230769 25.2 25 2 small seminal vesicle 0.134290813502486 0.38324923700859 1.32975113122172 0.269230769230769 25.2 25 2 increased blood urea nitrogen level 0.00152055282577148 0.017271119425144 1.32844103158505 0.268965517241379 25.2 25 2 decreased white adipose tissue amount 0.0259006012378886 0.134504688056885 1.32691584096325 0.26865671641791 25.2 25 2 abnormal axon morphology 0.00583185593899401 0.0455470695392389 1.32623327108621 0.268518518518519 25.2 25 2 thick ventricular wall 0.0723052336818988 0.256729213563399 1.32511785201886 0.268292682926829 25.2 25 2 abnormal neuron differentiation 0.00530665080232326 0.0429277849456231 1.32296668667467 0.267857142857143 25.2 25 2 abnormal seminal vesicle morphology 0.0406677746380813 0.172189088361238 1.32296668667467 0.267857142857143 25.2 25 2 decreased liver weight 0.0234293748374095 0.124133269239736 1.32172446443366 0.267605633802817 25.2 25 2 abnormal CD4-positive, alpha-beta T cell physiology 0.0234293748374095 0.124133269239736 1.32172446443366 0.267605633802817 25.2 25 2 altered response to myocardial infarction 0.0647789618609023 0.24249460892249 1.31708683473389 0.266666666666667 25.2 25 2 decreased osteoclast cell number 0.0647789618609023 0.24249460892249 1.31708683473389 0.266666666666667 25.2 25 2 abnormal humoral immune response 0.00736468642523845 0.0544417755803288 1.31708683473389 0.266666666666667 25.2 25 2 abnormal eye physiology 0.0366612617885512 0.160413172733547 1.31708683473389 0.266666666666667 25.2 25 2 abnormal estrous cycle 0.118838762519355 0.364502369626257 1.31708683473389 0.266666666666667 25.2 25 2 emphysema 0.118838762519355 0.364502369626257 1.31708683473389 0.266666666666667 25.2 25 2 abnormal response to infection 0.0191897533571459 0.106908200393954 1.31291883842144 0.265822784810127 25.2 25 2 abnormal lens morphology 0.00363952299850318 0.0336554403671995 1.31194196428571 0.265625 25.2 25 2 decreased lymphocyte cell number 0.00363952299850318 0.0336554403671995 1.31194196428571 0.265625 25.2 25 2 decreased circulating LDL cholesterol level 0.0330684703791431 0.149559672851124 1.31194196428571 0.265625 25.2 25 2 decreased circulating alanine transaminase level 0.0298440489128321 0.139806161338361 1.30740237271379 0.264705882352941 25.2 25 2 abnormal oocyte morphology 0.10547815613875 0.329810995219775 1.30740237271379 0.264705882352941 25.2 25 2 thin skin 0.10547815613875 0.329810995219775 1.30740237271379 0.264705882352941 25.2 25 2 impaired synaptic plasticity 0.10547815613875 0.329810995219775 1.30740237271379 0.264705882352941 25.2 25 2 abnormal skin physiology 0.10547815613875 0.329810995219775 1.30740237271379 0.264705882352941 25.2 25 2 abnormal retinal pigmentation 0.015736391437167 0.0957664941232414 1.30573263788274 0.264367816091954 25.2 25 2 abnormal heart left ventricle morphology 0.0269479322765776 0.136466118016056 1.30336718020542 0.263888888888889 25.2 25 2 increased bone marrow cell number 0.0938528381235582 0.308196613640067 1.29975674480318 0.263157894736842 25.2 25 2 abnormal reproductive system physiology 0.0938528381235582 0.308196613640067 1.29975674480318 0.263157894736842 25.2 25 2 decreased total retina thickness 0.0938528381235582 0.308196613640067 1.29975674480318 0.263157894736842 25.2 25 2 decreased threshold for auditory brainstem response 0.0938528381235582 0.308196613640067 1.29975674480318 0.263157894736842 25.2 25 2 irregular coat pigmentation 0.204857944259208 0.451758986121259 1.29975674480318 0.263157894736842 25.2 25 2 short vibrissae 0.204857944259208 0.451758986121259 1.29975674480318 0.263157894736842 25.2 25 2 abnormal long term depression 0.204857944259208 0.451758986121259 1.29975674480318 0.263157894736842 25.2 25 2 increased malignant tumor incidence 0.204857944259208 0.451758986121259 1.29975674480318 0.263157894736842 25.2 25 2 abnormal neurotransmitter level 0.204857944259208 0.451758986121259 1.29975674480318 0.263157894736842 25.2 25 2 maternal imprinting 0.204857944259208 0.451758986121259 1.29975674480318 0.263157894736842 25.2 25 2 abnormal optic vesicle formation 0.204857944259208 0.451758986121259 1.29975674480318 0.263157894736842 25.2 25 2 abnormal photoreceptor inner segment morphology 0.204857944259208 0.451758986121259 1.29975674480318 0.263157894736842 25.2 25 2 increased left ventricle weight 0.204857944259208 0.451758986121259 1.29975674480318 0.263157894736842 25.2 25 2 arrest of spermatogenesis 0.0198952763783078 0.109178563013025 1.29356742697079 0.261904761904762 25.2 25 2 teratozoospermia 0.0179967447675828 0.102015635587274 1.29089476699771 0.261363636363636 25.2 25 2 abnormal spermatogenesis 0.000979557386860928 0.012368776648815 1.28845451223968 0.260869565217391 25.2 25 2 abnormal testis morphology 0.00792525489593333 0.0580679574481124 1.28845451223968 0.260869565217391 25.2 25 2 abnormal epidermal layer morphology 0.0342176852322146 0.154336340915927 1.28845451223968 0.260869565217391 25.2 25 2 abnormal sleep pattern 0.0747553247674931 0.256729213563399 1.28845451223968 0.260869565217391 25.2 25 2 abnormal carpal bone morphology 0.178423137146442 0.418507829940382 1.28845451223968 0.260869565217391 25.2 25 2 conjunctivitis 0.178423137146442 0.418507829940382 1.28845451223968 0.260869565217391 25.2 25 2 abnormal sacral vertebrae morphology 0.178423137146442 0.418507829940382 1.28845451223968 0.260869565217391 25.2 25 2 decreased epididymis weight 0.178423137146442 0.418507829940382 1.28845451223968 0.260869565217391 25.2 25 2 decreased effector memory CD8-positive, alpha-beta T cell number 0.178423137146442 0.418507829940382 1.28845451223968 0.260869565217391 25.2 25 2 astrocytosis 0.0308503726613716 0.143305886078734 1.28551283527109 0.26027397260274 25.2 25 2 increased body length 0.0668839381073937 0.249435976075175 1.28415966386555 0.26 25.2 25 2 short stride length 0.0668839381073937 0.249435976075175 1.28415966386555 0.26 25.2 25 2 increased circulating chloride level 0.0668839381073937 0.249435976075175 1.28415966386555 0.26 25.2 25 2 abnormal axon extension 0.0668839381073937 0.249435976075175 1.28415966386555 0.26 25.2 25 2 abnormal circulating protein level 0.0668839381073937 0.249435976075175 1.28415966386555 0.26 25.2 25 2 axon degeneration 0.0599246899031982 0.23382379001444 1.28050108932462 0.259259259259259 25.2 25 2 abnormal trigeminal ganglion morphology 0.156403331455423 0.39870178214528 1.28050108932462 0.259259259259259 25.2 25 2 abnormal bone trabecula morphology 0.156403331455423 0.39870178214528 1.28050108932462 0.259259259259259 25.2 25 2 abnormal gait 3.53486149926522e-05 0.000901842869684331 1.27872508226592 0.258899676375405 25.2 25 2 thrombocytosis 0.0537558017050949 0.212587530590498 1.27734714575485 0.258620689655172 25.2 25 2 absent mature ovarian follicles 0.137772236635205 0.38324923700859 1.2746001626457 0.258064516129032 25.2 25 2 abnormal intestine physiology 0.137772236635205 0.38324923700859 1.2746001626457 0.258064516129032 25.2 25 2 abnormal mitochondrial ATP synthesis coupled electron transport 0.137772236635205 0.38324923700859 1.2746001626457 0.258064516129032 25.2 25 2 impaired fertilization 0.0390450894873063 0.166309349485744 1.27004801920768 0.257142857142857 25.2 25 2 abnormal action potential 0.0390450894873063 0.166309349485744 1.27004801920768 0.257142857142857 25.2 25 2 decreased neutrophil cell number 0.0102035022244731 0.0684129697665141 1.26642964878259 0.256410256410256 25.2 25 2 abnormal heart looping 0.108067035023955 0.33644148888872 1.26642964878259 0.256410256410256 25.2 25 2 abnormal circulating hormone level 0.108067035023955 0.33644148888872 1.26642964878259 0.256410256410256 25.2 25 2 increased circulating creatinine level 0.0257790806008203 0.134013506780649 1.26348446355286 0.255813953488372 25.2 25 2 increased neutrophil cell number 0.00515432422432135 0.0418999395686253 1.26031585047812 0.255172413793103 25.2 25 2 abnormal response to novel object 0.0764925478598372 0.259938815302384 1.25898006261328 0.254901960784314 25.2 25 2 impaired coordination 3.05288678027088e-05 0.00079104748603373 1.25618108515082 0.254335260115607 25.2 25 2 abnormal colon morphology 0.0612809949471055 0.238928644092359 1.25569719413189 0.254237288135593 25.2 25 2 increased circulating aspartate transaminase level 0.0549588933086394 0.217000392230541 1.25436841403228 0.253968253968254 25.2 25 2 decreased circulating glucose level 0.000284939929606389 0.00468894075192882 1.23919460257221 0.25089605734767 25.2 25 2 abnormal motor capabilities/coordination/movement 0.0108395479449513 0.0718065925780727 1.23476890756303 0.25 25.2 25 2 increased food intake 0.0365174862170155 0.159924730571877 1.23476890756303 0.25 25.2 25 2 decreased body temperature 0.0869436230520391 0.288940898252435 1.23476890756303 0.25 25.2 25 2 kidney cortex cysts 0.158112211897307 0.39870178214528 1.23476890756303 0.25 25.2 25 2 abnormal lumbar vertebrae morphology 0.158112211897307 0.39870178214528 1.23476890756303 0.25 25.2 25 2 abnormal depression-related behavior 0.158112211897307 0.39870178214528 1.23476890756303 0.25 25.2 25 2 abnormal auditory brainstem response waveform shape 0.158112211897307 0.39870178214528 1.23476890756303 0.25 25.2 25 2 ocular hypertelorism 0.206180573560443 0.452669176285616 1.23476890756303 0.25 25.2 25 2 abnormal sensory capabilities/reflexes/nociception 0.206180573560443 0.452669176285616 1.23476890756303 0.25 25.2 25 2 abnormal primitive streak formation 0.206180573560443 0.452669176285616 1.23476890756303 0.25 25.2 25 2 abnormal impulse conducting system conduction 0.206180573560443 0.452669176285616 1.23476890756303 0.25 25.2 25 2 decreased ovulation rate 0.206180573560443 0.452669176285616 1.23476890756303 0.25 25.2 25 2 abnormal tumor morphology 0.206180573560443 0.452669176285616 1.23476890756303 0.25 25.2 25 2 abnormal inner cell mass apoptosis 0.206180573560443 0.452669176285616 1.23476890756303 0.25 25.2 25 2 increased susceptibility to bacterial infection induced morbidity/mortality 0.05014874223549 0.202986875963865 1.23476890756303 0.25 25.2 25 2 epidermal hyperplasia 0.0694875726666236 0.25607457334552 1.23476890756303 0.25 25.2 25 2 abnormal circadian rhythm 0.109572790479746 0.340277548462383 1.23476890756303 0.25 25.2 25 2 abnormal gametogenesis 0.109572790479746 0.340277548462383 1.23476890756303 0.25 25.2 25 2 renal interstitial fibrosis 0.109572790479746 0.340277548462383 1.23476890756303 0.25 25.2 25 2 abnormal skin pigmentation 0.123436027929873 0.378136846644777 1.23476890756303 0.25 25.2 25 2 increased susceptibility to weight loss 0.123436027929873 0.378136846644777 1.23476890756303 0.25 25.2 25 2 abnormal stria vascularis morphology 0.180048765544249 0.420570282999675 1.23476890756303 0.25 25.2 25 2 abnormal respiration 0.180048765544249 0.420570282999675 1.23476890756303 0.25 25.2 25 2 abnormal retinal inner nuclear layer morphology 0.180048765544249 0.420570282999675 1.23476890756303 0.25 25.2 25 2 abnormal basioccipital bone morphology 0.237875694632327 0.507692655854065 1.23476890756303 0.25 25.2 25 2 abnormal dopamine level 0.237875694632327 0.507692655854065 1.23476890756303 0.25 25.2 25 2 abnormal hearing physiology 0.237875694632327 0.507692655854065 1.23476890756303 0.25 25.2 25 2 abnormal fibula morphology 0.237875694632327 0.507692655854065 1.23476890756303 0.25 25.2 25 2 abnormal Peyer's patch T cell area morphology 0.237875694632327 0.507692655854065 1.23476890756303 0.25 25.2 25 2 decreased paired-pulse facilitation 0.237875694632327 0.507692655854065 1.23476890756303 0.25 25.2 25 2 abnormal hyoid bone morphology 0.237875694632327 0.507692655854065 1.23476890756303 0.25 25.2 25 2 abnormal postnatal subventricular zone morphology 0.237875694632327 0.507692655854065 1.23476890756303 0.25 25.2 25 2 abnormal induced retinal neovascularization 0.237875694632327 0.507692655854065 1.23476890756303 0.25 25.2 25 2 increased exploration in new environment 0.0456161393083807 0.191834567252066 1.21952484697583 0.246913580246914 25.2 25 2 decreased percent body fat/body weight 0.0564645722779288 0.22259211337773 1.21785426499367 0.246575342465753 25.2 25 2 decreased susceptibility to induced arthritis 0.0876857969565843 0.291212843697601 1.21310629514964 0.245614035087719 25.2 25 2 abnormal pancreatic islet morphology 0.098244094940527 0.310485728814704 1.21147138100523 0.245283018867925 25.2 25 2 increased fluid intake 0.110281544341297 0.342264930192109 1.20956954210256 0.244897959183673 25.2 25 2 irregular heartbeat 0.12406491150349 0.379595900817873 1.20732959850607 0.244444444444444 25.2 25 2 arrested B cell differentiation 0.139929832525994 0.388043989307035 1.20465259274441 0.24390243902439 25.2 25 2 abnormal excitatory postsynaptic currents 0.0568607212154502 0.223622203989617 1.20310816634346 0.243589743589744 25.2 25 2 increased circulating alanine transaminase level 0.0568607212154502 0.223622203989617 1.20310816634346 0.243589743589744 25.2 25 2 increased embryonic tissue cell apoptosis 0.0568607212154502 0.223622203989617 1.20310816634346 0.243589743589744 25.2 25 2 abnormal long bone metaphysis morphology 0.158307400398439 0.39870178214528 1.20139677492619 0.243243243243243 25.2 25 2 abnormal breathing pattern 0.158307400398439 0.39870178214528 1.20139677492619 0.243243243243243 25.2 25 2 abnormal chromosome morphology 0.158307400398439 0.39870178214528 1.20139677492619 0.243243243243243 25.2 25 2 lung inflammation 0.0168228595268712 0.0963103868195448 1.19845217498764 0.242647058823529 25.2 25 2 abnormal epidermis stratum basale morphology 0.179765679530992 0.420570282999675 1.1973516679399 0.242424242424242 25.2 25 2 abnormal skeleton physiology 0.179765679530992 0.420570282999675 1.1973516679399 0.242424242424242 25.2 25 2 diarrhea 0.179765679530992 0.420570282999675 1.1973516679399 0.242424242424242 25.2 25 2 cardiovascular system phenotype 0.179765679530992 0.420570282999675 1.1973516679399 0.242424242424242 25.2 25 2 impaired righting response 0.0416439133237281 0.176172167334649 1.19577620521893 0.242105263157895 25.2 25 2 abnormal immune system physiology 0.0226909513832553 0.120864542967553 1.19493765248035 0.241935483870968 25.2 25 2 abnormal enzyme/coenzyme level 0.0984817045366036 0.310485728814704 1.1921906693712 0.241379310344828 25.2 25 2 abnormal CD8-positive, alpha-beta T cell physiology 0.205077833209979 0.451843321620746 1.1921906693712 0.241379310344828 25.2 25 2 increased double-positive T cell number 0.205077833209979 0.451843321620746 1.1921906693712 0.241379310344828 25.2 25 2 kidney inflammation 0.123986051573055 0.3795880655852 1.1853781512605 0.24 25.2 25 2 increased pre-B cell number 0.235341008111215 0.507068651084148 1.1853781512605 0.24 25.2 25 2 decreased acute inflammation 0.235341008111215 0.507068651084148 1.1853781512605 0.24 25.2 25 2 increased bone mineral density 0.0340819100602796 0.153863432440917 1.18013311519298 0.238938053097345 25.2 25 2 increased liver weight 0.0571161755188912 0.224449425913494 1.17864304812834 0.238636363636364 25.2 25 2 abnormal vibrissa morphology 0.157506205818145 0.39870178214528 1.17597038815526 0.238095238095238 25.2 25 2 abnormal eye pigmentation 0.272200608627387 0.5626082376075 1.17597038815526 0.238095238095238 25.2 25 2 trunk curl 0.272200608627387 0.5626082376075 1.17597038815526 0.238095238095238 25.2 25 2 dry skin 0.272200608627387 0.5626082376075 1.17597038815526 0.238095238095238 25.2 25 2 decreased cochlear outer hair cell number 0.272200608627387 0.5626082376075 1.17597038815526 0.238095238095238 25.2 25 2 skin lesions 0.0983285972941103 0.310485728814704 1.17597038815526 0.238095238095238 25.2 25 2 abnormal social investigation 0.0706367340555845 0.256729213563399 1.17303046218487 0.2375 25.2 25 2 abnormal blood homeostasis 0.0377168320647316 0.162535683951905 1.16978107032287 0.236842105263158 25.2 25 2 abnormal retinal outer nuclear layer morphology 0.178310540414781 0.418507829940382 1.16978107032287 0.236842105263158 25.2 25 2 increased kidney weight 0.138599437330969 0.384568990921121 1.16213544241226 0.235294117647059 25.2 25 2 abnormal endoderm development 0.202623379036297 0.448620966046096 1.16213544241226 0.235294117647059 25.2 25 2 abnormal nervous system development 0.202623379036297 0.448620966046096 1.16213544241226 0.235294117647059 25.2 25 2 abnormal direction of heart looping 0.202623379036297 0.448620966046096 1.16213544241226 0.235294117647059 25.2 25 2 decreased regulatory T cell number 0.202623379036297 0.448620966046096 1.16213544241226 0.235294117647059 25.2 25 2 increased susceptibility to weight gain 0.202623379036297 0.448620966046096 1.16213544241226 0.235294117647059 25.2 25 2 increased respiratory quotient 0.156032010092121 0.39870178214528 1.15595387091007 0.234042553191489 25.2 25 2 abnormal hair cycle 0.231324506898429 0.498846736809573 1.15245098039216 0.233333333333333 25.2 25 2 arrested T cell differentiation 0.231324506898429 0.498846736809573 1.15245098039216 0.233333333333333 25.2 25 2 salivary gland inflammation 0.231324506898429 0.498846736809573 1.15245098039216 0.233333333333333 25.2 25 2 abnormal spatial learning 0.0205287343354714 0.111862489944108 1.15144094447595 0.233128834355828 25.2 25 2 abnormal homeostasis 0.176111501178029 0.414257550052338 1.14862223959351 0.232558139534884 25.2 25 2 hyperkeratosis 0.108422127668737 0.337335888150072 1.1452928997686 0.231884057971014 25.2 25 2 abnormal excitatory postsynaptic potential 0.0865043300551124 0.287673156433278 1.14441996310719 0.231707317073171 25.2 25 2 decreased trabecular bone volume 0.199383592032029 0.442780071262852 1.13978668390433 0.230769230769231 25.2 25 2 increased anxiety-related response 0.0368152265656617 0.1609453006715 1.13705338250408 0.23021582733813 25.2 25 2 abnormal intestinal goblet cell morphology 0.226562574495158 0.495641145683938 1.12893157262905 0.228571428571429 25.2 25 2 decreased circulating thyroxine level 0.226562574495158 0.495641145683938 1.12893157262905 0.228571428571429 25.2 25 2 decreased brain weight 0.151841789589066 0.39870178214528 1.12645584549609 0.228070175438596 25.2 25 2 decreased anxiety-related response 0.0546262918352047 0.215858460587882 1.12434241989479 0.227642276422764 25.2 25 2 cochlear hair cell degeneration 0.195681710206936 0.442780071262852 1.12251718869366 0.227272727272727 25.2 25 2 decreased airway responsiveness 0.307464416229178 0.571654686338469 1.12251718869366 0.227272727272727 25.2 25 2 increased myocardial infarction size 0.307464416229178 0.571654686338469 1.12251718869366 0.227272727272727 25.2 25 2 abnormal retinal outer plexiform layer morphology 0.307464416229178 0.571654686338469 1.12251718869366 0.227272727272727 25.2 25 2 impaired humoral immune response 0.307464416229178 0.571654686338469 1.12251718869366 0.227272727272727 25.2 25 2 decreased exploration in new environment 0.10452479539721 0.327875698046104 1.1171718687475 0.226190476190476 25.2 25 2 abnormal body temperature homeostasis 0.258610585725203 0.550294124885751 1.11527514231499 0.225806451612903 25.2 25 2 autoimmune response 0.258610585725203 0.550294124885751 1.11527514231499 0.225806451612903 25.2 25 2 abnormal nose morphology 0.258610585725203 0.550294124885751 1.11527514231499 0.225806451612903 25.2 25 2 abnormal pancreatic beta cell morphology 0.22143288483588 0.485298943638107 1.11129201680672 0.225 25.2 25 2 organ of Corti degeneration 0.191712904186207 0.44197020311695 1.10877208026068 0.224489795918367 25.2 25 2 decreased urine osmolality 0.191712904186207 0.44197020311695 1.10877208026068 0.224489795918367 25.2 25 2 reduced long term potentiation 0.0802916689697058 0.270814273304601 1.10247223889556 0.223214285714286 25.2 25 2 deafness 0.0997621044697417 0.314124347934788 1.09757236227824 0.222222222222222 25.2 25 2 abnormal CNS synaptic transmission 0.0997621044697417 0.314124347934788 1.09757236227824 0.222222222222222 25.2 25 2 abnormal ovarian follicle morphology 0.216143652693635 0.473915677457397 1.09757236227824 0.222222222222222 25.2 25 2 increased circulating corticosterone level 0.216143652693635 0.473915677457397 1.09757236227824 0.222222222222222 25.2 25 2 abnormal inflammatory response 0.144028655150196 0.397241843265744 1.09757236227824 0.222222222222222 25.2 25 2 abnormal epidermis stratum granulosum morphology 0.251449935586074 0.535744509439279 1.09757236227824 0.222222222222222 25.2 25 2 cryptorchism 0.296871133647666 0.571654686338469 1.09757236227824 0.222222222222222 25.2 25 2 decreased birth weight 0.110459827268395 0.342604514127348 1.09179566563467 0.221052631578947 25.2 25 2 testicular atrophy 0.210815349795043 0.462640655152333 1.08659663865546 0.22 25.2 25 2 increased circulating follicle stimulating hormone level 0.286750130397014 0.571654686338469 1.08042279411765 0.21875 25.2 25 2 abnormal serotonin level 0.286750130397014 0.571654686338469 1.08042279411765 0.21875 25.2 25 2 abnormal learning/memory/conditioning 0.205519844574174 0.452616744912136 1.07761650114591 0.218181818181818 25.2 25 2 embryonic lethality between implantation and placentation, complete penetrance 0.23741627561077 0.507692655854065 1.07371209353307 0.217391304347826 25.2 25 2 abnormal cranial nerve morphology 0.343309215974382 0.617931747276609 1.07371209353307 0.217391304347826 25.2 25 2 bidirectional circling 0.343309215974382 0.617931747276609 1.07371209353307 0.217391304347826 25.2 25 2 failure of embryo implantation 0.343309215974382 0.617931747276609 1.07371209353307 0.217391304347826 25.2 25 2 abnormal corneal stroma morphology 0.343309215974382 0.617931747276609 1.07371209353307 0.217391304347826 25.2 25 2 increased susceptibility to fungal infection 0.343309215974382 0.617931747276609 1.07371209353307 0.217391304347826 25.2 25 2 abnormal lens development 0.343309215974382 0.617931747276609 1.07371209353307 0.217391304347826 25.2 25 2 abnormal T cell activation 0.170951023197889 0.404605775646764 1.06790824437883 0.216216216216216 25.2 25 2 increased brown adipose tissue amount 0.277144428051627 0.566601524378334 1.06790824437883 0.216216216216216 25.2 25 2 abnormal respiratory electron transport chain 0.277144428051627 0.566601524378334 1.06790824437883 0.216216216216216 25.2 25 2 decreased monocyte cell number 0.195184181312769 0.442780071262852 1.06380090497738 0.215384615384615 25.2 25 2 enhanced long term potentiation 0.224149878250601 0.490821146257368 1.05837334933974 0.214285714285714 25.2 25 2 abnormal spleen germinal center morphology 0.328731779494053 0.602708954136262 1.05837334933974 0.214285714285714 25.2 25 2 straub tail 0.328731779494053 0.602708954136262 1.05837334933974 0.214285714285714 25.2 25 2 increased systemic arterial blood pressure 0.259412023048243 0.55176349494015 1.05086715537279 0.212765957446809 25.2 25 2 dextrocardia 0.315553636399405 0.584467364514907 1.04768270944742 0.212121212121212 25.2 25 2 decreased sensitivity to xenobiotic induced morbidity/mortality 0.315553636399405 0.584467364514907 1.04768270944742 0.212121212121212 25.2 25 2 circling 0.175967908455169 0.414115583994543 1.04592189817103 0.211764705882353 25.2 25 2 decreased kidney weight 0.251220188776035 0.535484335544461 1.04480446024564 0.211538461538462 25.2 25 2 increased percent body fat/body weight 0.251220188776035 0.535484335544461 1.04480446024564 0.211538461538462 25.2 25 2 seizures 0.140872900521287 0.390441604508858 1.03980539584255 0.210526315789474 25.2 25 2 hyporesponsive to tactile stimuli 0.303500131421453 0.571654686338469 1.03980539584255 0.210526315789474 25.2 25 2 maternal effect 0.228942245531433 0.495641145683938 1.03204565408253 0.208955223880597 25.2 25 2 cochlear outer hair cell degeneration 0.222185712055115 0.486734441864463 1.02897408963585 0.208333333333333 25.2 25 2 hemolytic anemia 0.379395700820156 0.673383379086791 1.02897408963585 0.208333333333333 25.2 25 2 blindness 0.379395700820156 0.673383379086791 1.02897408963585 0.208333333333333 25.2 25 2 increased hemangiosarcoma incidence 0.379395700820156 0.673383379086791 1.02897408963585 0.208333333333333 25.2 25 2 decreased fatty acid level 0.379395700820156 0.673383379086791 1.02897408963585 0.208333333333333 25.2 25 2 cochlear ganglion degeneration 0.263303803041651 0.553493113315747 1.02187771660388 0.206896551724138 25.2 25 2 focal hair loss 0.360989330698594 0.646247542362542 1.02187771660388 0.206896551724138 25.2 25 2 enlarged epididymis 0.360989330698594 0.646247542362542 1.02187771660388 0.206896551724138 25.2 25 2 abnormal eye electrophysiology 0.157414305056617 0.39870178214528 1.02047017153969 0.206611570247934 25.2 25 2 abnormal inhibitory postsynaptic currents 0.246665774679394 0.526227370939103 1.01686851211073 0.205882352941176 25.2 25 2 decreased pancreatic beta cell number 0.344831851271322 0.620447905994512 1.01686851211073 0.205882352941176 25.2 25 2 acanthosis 0.330368915780015 0.604531995468402 1.01314371902607 0.205128205128205 25.2 25 2 abnormal lens fiber morphology 0.330368915780015 0.604531995468402 1.01314371902607 0.205128205128205 25.2 25 2 abnormal cochlea morphology 0.294062992876146 0.571654686338469 1.00610799875506 0.203703703703704 25.2 25 2 abnormal neuronal precursor proliferation 0.294062992876146 0.571654686338469 1.00610799875506 0.203703703703704 25.2 25 2 dehydration 0.283566710821353 0.571654686338469 0.98781512605042 0.2 25.2 25 2 decreased circulating alkaline phosphatase level 0.328794392266495 0.602708954136262 0.98781512605042 0.2 25.2 25 2 abnormal synaptic transmission 0.393405536648636 0.694605437882697 0.98781512605042 0.2 25.2 25 2 abnormal male meiosis 0.32578144833358 0.601842816732106 0.97162143545943 0.19672131147541 25.2 25 2 cochlear inner hair cell degeneration 0.352726018252796 0.634192967404286 0.968446202010216 0.196078431372549 25.2 25 2 scaly skin 0.385056815690112 0.683187467210523 0.963722074195532 0.195121951219512 25.2 25 2 abnormal uterus morphology 0.404076571987951 0.694605437882697 0.960375816993464 0.194444444444444 25.2 25 2 impaired natural killer cell mediated cytotoxicity 0.361481002176394 0.646662346575893 0.953154946189002 0.192982456140351 25.2 25 2 abnormal circulating amino acid level 0.361481002176394 0.646662346575893 0.953154946189002 0.192982456140351 25.2 25 2 abnormal skin condition 0.37689407289012 0.672761909439643 0.949822236586943 0.192307692307692 25.2 25 2 abnormal female meiosis 0.37689407289012 0.672761909439643 0.949822236586943 0.192307692307692 25.2 25 2 decreased circulating glycerol level 0.451064923402999 0.730960258609095 0.949822236586943 0.192307692307692 25.2 25 2 abnormal nervous system electrophysiology 0.33623177024667 0.60650944777998 0.94077631052421 0.19047619047619 25.2 25 2 abnormal urine homeostasis 0.348031176994385 0.625977984651867 0.926076680672269 0.1875 25.2 25 2 abnormal crypts of Lieberkuhn morphology 0.457834677441009 0.740965361180553 0.926076680672269 0.1875 25.2 25 2 increased dopamine level 0.457834677441009 0.740965361180553 0.926076680672269 0.1875 25.2 25 2 decreased susceptibility to parasitic infection 0.457834677441009 0.740965361180553 0.926076680672269 0.1875 25.2 25 2 abnormal locomotor activation 0.360315300536583 0.64550544478556 0.922684458398744 0.186813186813187 25.2 25 2 abnormal intestinal mucosa morphology 0.440067112512968 0.714767837006861 0.918897791674809 0.186046511627907 25.2 25 2 abnormal left-right axis patterning 0.440067112512968 0.714767837006861 0.918897791674809 0.186046511627907 25.2 25 2 thick interventricular septum 0.486108966529211 0.773637910583117 0.914643635231871 0.185185185185185 25.2 25 2 impaired swimming 0.435159619014848 0.707258773145661 0.898013750954928 0.181818181818182 25.2 25 2 increased cardiomyocyte apoptosis 0.489452686561365 0.778710302412149 0.898013750954928 0.181818181818182 25.2 25 2 abnormal photoreceptor outer segment morphology 0.467361882824965 0.747869207801287 0.898013750954927 0.181818181818182 25.2 25 2 abnormal amino acid level 0.467361882824965 0.747869207801287 0.898013750954927 0.181818181818182 25.2 25 2 increased susceptibility to parasitic infection 0.448899934675472 0.727688880746325 0.878057889822596 0.177777777777778 25.2 25 2 increased susceptibility to pharmacologically induced seizures 0.451610105737619 0.731605430167585 0.874627976190476 0.177083333333333 25.2 25 2 decreased cytotoxic T cell cytolysis 0.520442865552088 0.783903624684075 0.871601581809194 0.176470588235294 25.2 25 2 abnormal inner ear morphology 0.52094033212448 0.783903624684075 0.858969674826452 0.173913043478261 25.2 25 2 abnormal food intake 0.500826698672593 0.783903624684075 0.858969674826452 0.173913043478261 25.2 25 2 abnormal brain wave pattern 0.521258455385413 0.783903624684075 0.854840012928248 0.173076923076923 25.2 25 2 decreased retinal photoreceptor cell number 0.553515579283955 0.830941462564174 0.851564763836569 0.172413793103448 25.2 25 2 stomach inflammation 0.553515579283955 0.830941462564174 0.851564763836569 0.172413793103448 25.2 25 2 increased susceptibility to induced arthritis 0.553515579283955 0.830941462564174 0.851564763836569 0.172413793103448 25.2 25 2 abnormal response to new environment 0.585537587811018 0.872954599748221 0.823179271708683 0.166666666666667 25.2 25 2 abnormal pain threshold 0.585537587811018 0.872954599748221 0.823179271708683 0.166666666666667 25.2 25 2 abnormal vocalization 0.608287734302157 0.884345843995685 0.800931183284124 0.162162162162162 25.2 25 2 abnormal CD8-positive, alpha beta T cell morphology 0.616264753761164 0.895419728376691 0.796625101653565 0.161290322580645 25.2 25 2 decreased susceptibility to bacterial infection induced morbidity/mortality 0.616264753761164 0.895419728376691 0.796625101653565 0.161290322580645 25.2 25 2 abnormal digestive system physiology 0.621376442558362 0.902583299774555 0.790252100840336 0.16 25.2 25 2 increased grooming behavior 0.635511802476792 0.918289636166727 0.779854046881911 0.157894736842105 25.2 25 2 abnormal long term potentiation 0.645603656783414 0.930170342455108 0.771730567226891 0.15625 25.2 25 2 increased autoantibody level 0.661581942432798 0.94574150434988 0.759857789269554 0.153846153846154 25.2 25 2 increased thermal nociceptive threshold 0.68705753626092 0.969952112059613 0.759857789269554 0.153846153846154 25.2 25 2 abnormal coat/ hair morphology 0.688646041859332 0.971918881773099 0.745520849849374 0.150943396226415 25.2 25 2 impaired behavioral response to xenobiotic 0.724744143580666 1 0.705582232893157 0.142857142857143 25.2 25 2 head tilt 0.74809396535782 1 0.685982726423903 0.138888888888889 25.2 25 2 head bobbing 0.82677734676488 1 0.617384453781513 0.125 25.2 25 2 abnormal lambdoidal suture morphology 5.03078621805392e-05 0.00127694701198052 4.20306748466258 1 25.3 25 3 increased T follicular helper cell number 0.000261917479248152 0.00501442909543649 4.20306748466258 1 25.3 25 3 abnormal second pharyngeal arch artery morphology 0.000261917479248152 0.00501442909543649 4.20306748466258 1 25.3 25 3 increased aorta wall thickness 6.43063839821885e-05 0.00157598157788861 3.67768404907975 0.875 25.3 25 3 abnormal umbilical vein topology 6.43063839821885e-05 0.00157598157788861 3.67768404907975 0.875 25.3 25 3 decreased cardiomyocyte apoptosis 0.000294184857615794 0.00546108084566632 3.60262927256792 0.857142857142857 25.3 25 3 abnormal retina inner limiting membrane morphology 0.000294184857615794 0.00546108084566632 3.60262927256792 0.857142857142857 25.3 25 3 abnormal conotruncal ridge morphology 0.000294184857615794 0.00546108084566632 3.60262927256792 0.857142857142857 25.3 25 3 increased compact bone volume 0.000294184857615794 0.00546108084566632 3.60262927256792 0.857142857142857 25.3 25 3 abnormal hippocampal fimbria morphology 0.00131996556458622 0.017190651004755 3.50255623721881 0.833333333333333 25.3 25 3 decreased liver function 0.00131996556458622 0.017190651004755 3.50255623721881 0.833333333333333 25.3 25 3 decreased heart right ventricle size 0.00131996556458622 0.017190651004755 3.50255623721881 0.833333333333333 25.3 25 3 delayed limb development 0.00131996556458622 0.017190651004755 3.50255623721881 0.833333333333333 25.3 25 3 abnormal mitral valve morphology 1.29109876097509e-07 6.83320886792668e-06 3.26905248807089 0.777777777777778 25.3 25 3 increased cardiac output 0.000983820278516611 0.0138654557666293 3.15230061349693 0.75 25.3 25 3 binucleate 0.000983820278516611 0.0138654557666293 3.15230061349693 0.75 25.3 25 3 abnormal bronchiole morphology 0.000174893177709804 0.00353696568742389 3.05677635248187 0.727272727272727 25.3 25 3 vascular smooth muscle hypoplasia 3.18601217004021e-05 0.000829864426489531 3.00219106047327 0.714285714285714 25.3 25 3 increased cell nucleus count 0.00388441733201227 0.0386499524535221 3.00219106047327 0.714285714285714 25.3 25 3 abnormal sperm annulus morphology 0.00388441733201227 0.0386499524535221 3.00219106047327 0.714285714285714 25.3 25 3 osteosclerosis 0.000668979095413844 0.0103107979519768 2.9421472392638 0.7 25.3 25 3 thin ventricle myocardium compact layer 0.000668979095413844 0.0103107979519768 2.9421472392638 0.7 25.3 25 3 abnormal aorta elastic tissue morphology 0.000435838813616909 0.00740033480458745 2.80204498977505 0.666666666666667 25.3 25 3 prenatal growth retardation 0.000435838813616909 0.00740033480458745 2.80204498977505 0.666666666666667 25.3 25 3 decreased level of surface class I molecules 0.00246963934550755 0.0266517478175706 2.80204498977505 0.666666666666667 25.3 25 3 increased neuronal precursor cell number 0.00246963934550755 0.0266517478175706 2.80204498977505 0.666666666666667 25.3 25 3 eye opacity 0.00246963934550755 0.0266517478175706 2.80204498977505 0.666666666666667 25.3 25 3 abnormal hyoid bone lesser horn morphology 0.00246963934550755 0.0266517478175706 2.80204498977505 0.666666666666667 25.3 25 3 iris coloboma 0.00246963934550755 0.0266517478175706 2.80204498977505 0.666666666666667 25.3 25 3 symmetric azygos veins 0.00246963934550755 0.0266517478175706 2.80204498977505 0.666666666666667 25.3 25 3 increased hemangioma incidence 0.000277484306076836 0.00528921234763318 2.70197195442594 0.642857142857143 25.3 25 3 abnormal cell nucleus morphology 2.61019822776209e-11 3.32967594438882e-09 2.68280903276335 0.638297872340426 25.3 25 3 abnormal sphenoid bone morphology 0.00153362945139592 0.0190269489294132 2.67467930842164 0.636363636363636 25.3 25 3 loss of cortex neurons 0.00153362945139592 0.0190269489294132 2.67467930842164 0.636363636363636 25.3 25 3 abnormal Bruch membrane morphology 0.00153362945139592 0.0190269489294132 2.67467930842164 0.636363636363636 25.3 25 3 abnormal tympanic ring morphology 0.000174290809704553 0.00353696568742389 2.62691717791411 0.625 25.3 25 3 abnormal neuron apoptosis 0.00871874575450503 0.0700739258944467 2.62691717791411 0.625 25.3 25 3 abnormal extraembryonic tissue physiology 0.00871874575450503 0.0700739258944467 2.62691717791411 0.625 25.3 25 3 abnormal mitotic spindle assembly checkpoint 0.00871874575450503 0.0700739258944467 2.62691717791411 0.625 25.3 25 3 abnormal olfactory bulb mitral cell layer morphology 0.00871874575450503 0.0700739258944467 2.62691717791411 0.625 25.3 25 3 abnormal foramen magnum morphology 0.00871874575450503 0.0700739258944467 2.62691717791411 0.625 25.3 25 3 abnormal bronchus epithelium morphology 0.00871874575450503 0.0700739258944467 2.62691717791411 0.625 25.3 25 3 decreased cranium length 0.00871874575450503 0.0700739258944467 2.62691717791411 0.625 25.3 25 3 abnormal heart echocardiography feature 0.00871874575450503 0.0700739258944467 2.62691717791411 0.625 25.3 25 3 increased brain apoptosis 0.00871874575450503 0.0700739258944467 2.62691717791411 0.625 25.3 25 3 liver degeneration 2.06156987354678e-05 0.000589443110396277 2.60189891907683 0.619047619047619 25.3 25 3 abnormal aorta tunica media morphology 0.000941848043896788 0.0136609155055001 2.58650306748466 0.615384615384615 25.3 25 3 abnormal pericardium morphology 6.72424674712843e-05 0.00163257513132797 2.52184049079755 0.6 25.3 25 3 aneurysm 0.00517062972064809 0.0483531632710983 2.52184049079755 0.6 25.3 25 3 increased atrioventricular cushion size 0.00517062972064809 0.0483531632710983 2.52184049079755 0.6 25.3 25 3 abnormal gas homeostasis 0.00517062972064809 0.0483531632710983 2.52184049079755 0.6 25.3 25 3 increased platelet aggregation 0.00517062972064809 0.0483531632710983 2.52184049079755 0.6 25.3 25 3 protruding tongue 0.00517062972064809 0.0483531632710983 2.52184049079755 0.6 25.3 25 3 abnormal retinal blood vessel pattern 0.00517062972064809 0.0483531632710983 2.52184049079755 0.6 25.3 25 3 aorta stenosis 0.00517062972064809 0.0483531632710983 2.52184049079755 0.6 25.3 25 3 abnormal inferior vena cava valve morphology 0.00517062972064809 0.0483531632710983 2.52184049079755 0.6 25.3 25 3 fusion of atlas and odontoid process 0.00517062972064809 0.0483531632710983 2.52184049079755 0.6 25.3 25 3 lethality during fetal growth through weaning, complete penetrance 0.00517062972064809 0.0483531632710983 2.52184049079755 0.6 25.3 25 3 liver hemorrhage 9.89048640341089e-07 4.26618112128613e-05 2.52184049079755 0.6 25.3 25 3 delayed intramembranous bone ossification 0.000575177775307 0.00926054832411755 2.52184049079755 0.6 25.3 25 3 decreased thymocyte apoptosis 0.000575177775307 0.00926054832411755 2.52184049079755 0.6 25.3 25 3 abnormal aorta wall morphology 0.000575177775307 0.00926054832411755 2.52184049079755 0.6 25.3 25 3 abnormal atrioventricular cushion morphology 5.03049079538992e-06 0.000169099268290979 2.49070665757782 0.592592592592593 25.3 25 3 abnormal fetal cardiomyocyte proliferation 5.03049079538992e-06 0.000169099268290979 2.49070665757782 0.592592592592593 25.3 25 3 hyperlipidemia 0.000350240861645943 0.00626779959240491 2.47239263803681 0.588235294117647 25.3 25 3 impaired embryo implantation 0.00307053634428653 0.0316927765826255 2.45178936605317 0.583333333333333 25.3 25 3 altered tumor susceptibility 0.00307053634428653 0.0316927765826255 2.45178936605317 0.583333333333333 25.3 25 3 abnormal aorta elastic fiber morphology 0.00307053634428653 0.0316927765826255 2.45178936605317 0.583333333333333 25.3 25 3 abnormal defecation 0.00307053634428653 0.0316927765826255 2.45178936605317 0.583333333333333 25.3 25 3 abnormal rostral-caudal body axis extension 0.00307053634428653 0.0316927765826255 2.45178936605317 0.583333333333333 25.3 25 3 stria vascularis degeneration 0.00307053634428653 0.0316927765826255 2.45178936605317 0.583333333333333 25.3 25 3 hematuria 0.00307053634428653 0.0316927765826255 2.45178936605317 0.583333333333333 25.3 25 3 decreased mammary gland epithelial cell proliferation 0.00307053634428653 0.0316927765826255 2.45178936605317 0.583333333333333 25.3 25 3 liver hypoplasia 9.29383873450535e-10 8.86449623189487e-08 2.42484662576687 0.576923076923077 25.3 25 3 kinked neural tube 9.29383873450535e-10 8.86449623189487e-08 2.42484662576687 0.576923076923077 25.3 25 3 abnormal apoptosis 5.79347057900451e-10 6.00469086053072e-08 2.41287207452852 0.574074074074074 25.3 25 3 abnormal mitotic spindle morphology 9.63806765447793e-06 0.000307367862698895 2.40175284837862 0.571428571428571 25.3 25 3 abnormal sagittal suture morphology 0.00182766636099005 0.0218593834798114 2.40175284837862 0.571428571428571 25.3 25 3 vasculature congestion 0.00109060387393872 0.0150297902294879 2.3642254601227 0.5625 25.3 25 3 dystonia 0.00109060387393872 0.0150297902294879 2.3642254601227 0.5625 25.3 25 3 hydrops fetalis 7.92484594524137e-12 1.12646024507359e-09 2.33503749147921 0.555555555555556 25.3 25 3 abnormal thymus cortex morphology 0.000652348688723134 0.0101888133187327 2.33503749147921 0.555555555555556 25.3 25 3 decreased cellular sensitivity to gamma-irradiation 0.000652348688723134 0.0101888133187327 2.33503749147921 0.555555555555556 25.3 25 3 heart hyperplasia 0.0165301287657519 0.109503849014135 2.33503749147921 0.555555555555556 25.3 25 3 increased pheochromocytoma incidence 0.0165301287657519 0.109503849014135 2.33503749147921 0.555555555555556 25.3 25 3 abnormal posterior semicircular canal morphology 0.0165301287657519 0.109503849014135 2.33503749147921 0.555555555555556 25.3 25 3 abnormal thymus physiology 0.0165301287657519 0.109503849014135 2.33503749147921 0.555555555555556 25.3 25 3 decreased cellular sensitivity to ionizing radiation 0.0165301287657519 0.109503849014135 2.33503749147921 0.555555555555556 25.3 25 3 abnormal intervertebral disk development 0.0165301287657519 0.109503849014135 2.33503749147921 0.555555555555556 25.3 25 3 positive geotaxis 0.0165301287657519 0.109503849014135 2.33503749147921 0.555555555555556 25.3 25 3 retropulsion 0.0165301287657519 0.109503849014135 2.33503749147921 0.555555555555556 25.3 25 3 abnormal pulmonary alveolar system morphology 0.0165301287657519 0.109503849014135 2.33503749147921 0.555555555555556 25.3 25 3 abnormal oxidative phosphorylation 0.0165301287657519 0.109503849014135 2.33503749147921 0.555555555555556 25.3 25 3 increased myeloid cell number 0.0165301287657519 0.109503849014135 2.33503749147921 0.555555555555556 25.3 25 3 abnormal ductus venosus valve topology 0.0165301287657519 0.109503849014135 2.33503749147921 0.555555555555556 25.3 25 3 adipose tissue inflammation 0.0165301287657519 0.109503849014135 2.33503749147921 0.555555555555556 25.3 25 3 increased mammary adenocarcinoma incidence 0.000391067728334527 0.00677896149290687 2.31168711656442 0.55 25.3 25 3 increased skin tumor incidence 0.000391067728334527 0.00677896149290687 2.31168711656442 0.55 25.3 25 3 absent ductus venosus valve 0.000391067728334527 0.00677896149290687 2.31168711656442 0.55 25.3 25 3 abnormal ear position 0.00953503004375069 0.0741199601057183 2.29258226436141 0.545454545454545 25.3 25 3 delayed hepatic development 0.00953503004375069 0.0741199601057183 2.29258226436141 0.545454545454545 25.3 25 3 abnormal eye distance/ position 0.00953503004375069 0.0741199601057183 2.29258226436141 0.545454545454545 25.3 25 3 abnormal larynx morphology 0.00953503004375069 0.0741199601057183 2.29258226436141 0.545454545454545 25.3 25 3 retinal detachment 0.00953503004375069 0.0741199601057183 2.29258226436141 0.545454545454545 25.3 25 3 abnormal coronal suture morphology 0.00953503004375069 0.0741199601057183 2.29258226436141 0.545454545454545 25.3 25 3 pharyngeal arch hypoplasia 0.00953503004375069 0.0741199601057183 2.29258226436141 0.545454545454545 25.3 25 3 abnormal platelet aggregation 0.00953503004375069 0.0741199601057183 2.29258226436141 0.545454545454545 25.3 25 3 abnormal aorta smooth muscle morphology 0.00953503004375069 0.0741199601057183 2.29258226436141 0.545454545454545 25.3 25 3 common atrioventricular valve 0.00953503004375069 0.0741199601057183 2.29258226436141 0.545454545454545 25.3 25 3 abnormal placenta vasculature 2.69374795327159e-08 1.69637924905394e-06 2.26319018404908 0.538461538461538 25.3 25 3 ventricular hypoplasia 8.51997450034442e-05 0.00195710418332384 2.26319018404908 0.538461538461538 25.3 25 3 increased thymocyte apoptosis 8.51997450034442e-05 0.00195710418332384 2.26319018404908 0.538461538461538 25.3 25 3 abnormal pulmonary alveolus epithelial cell morphology 0.00555400602807456 0.0513590706127713 2.26319018404908 0.538461538461538 25.3 25 3 abnormal coping response 0.00555400602807456 0.0513590706127713 2.26319018404908 0.538461538461538 25.3 25 3 absent hypoglossal nerve 0.00555400602807456 0.0513590706127713 2.26319018404908 0.538461538461538 25.3 25 3 abnormal cell adhesion 1.65039745861264e-08 1.08035886271025e-06 2.2572029084299 0.537037037037037 25.3 25 3 abnormal branching involved in lung morphogenesis 0.00325908188748497 0.0330222655605656 2.24163599182004 0.533333333333333 25.3 25 3 heterochrony 0.00325908188748497 0.0330222655605656 2.24163599182004 0.533333333333333 25.3 25 3 abnormal spongiotrophoblast layer morphology 1.88084940832252e-05 0.000540880104416447 2.23287960122699 0.53125 25.3 25 3 increased fibroblast apoptosis 1.88084940832252e-05 0.000540880104416447 2.23287960122699 0.53125 25.3 25 3 abnormal adipose tissue morphology 0.00192351226276809 0.0222506812971434 2.22515337423313 0.529411764705882 25.3 25 3 abnormal dorsal-ventral axis patterning 0.00192351226276809 0.0222506812971434 2.22515337423313 0.529411764705882 25.3 25 3 abnormal ectoplacental cone morphology 0.00192351226276809 0.0222506812971434 2.22515337423313 0.529411764705882 25.3 25 3 increased brain size 0.00192351226276809 0.0222506812971434 2.22515337423313 0.529411764705882 25.3 25 3 increased hepatoma incidence 0.00192351226276809 0.0222506812971434 2.22515337423313 0.529411764705882 25.3 25 3 impaired hematopoiesis 7.6304891228396e-08 4.36341188346287e-06 2.22515337423313 0.529411764705882 25.3 25 3 decreased neuron apoptosis 4.1926994865876e-06 0.000147933900324633 2.21214078140136 0.526315789473684 25.3 25 3 kyphoscoliosis 0.00114055408190468 0.0153452983311987 2.21214078140136 0.526315789473684 25.3 25 3 increased liver adenoma incidence 0.00114055408190468 0.0153452983311987 2.21214078140136 0.526315789473684 25.3 25 3 abnormal erythropoiesis 2.96119505023613e-14 6.40519364127164e-12 2.2016067776804 0.523809523809524 25.3 25 3 complete atrioventricular septal defect 0.000678889587804895 0.0103922329210134 2.2016067776804 0.523809523809524 25.3 25 3 abnormal hematopoietic stem cell physiology 0.000405390381108311 0.00695454188280637 2.19290477460656 0.521739130434783 25.3 25 3 small heart 3.48968137359234e-07 1.70207498368842e-05 2.18909764826176 0.520833333333333 25.3 25 3 increased cell proliferation 7.90552354332503e-08 4.46931586682296e-06 2.1793683253806 0.518518518518518 25.3 25 3 decreased circulating fructosamine level 0.000145679275797891 0.00304518654241391 2.1793683253806 0.518518518518518 25.3 25 3 increased mortality induced by gamma-irradiation 8.76087177175161e-05 0.00199019803947325 2.17400042310133 0.517241379310345 25.3 25 3 myeloid hyperplasia 3.18469204962074e-05 0.000829864426489531 2.16521658300799 0.515151515151515 25.3 25 3 abnormal vasculogenesis 2.593967464108e-06 9.92691394918255e-05 2.15040662005992 0.511627906976744 25.3 25 3 abnormal angiogenesis 2.52566960537523e-09 1.93310865949873e-07 2.10153374233129 0.5 25.3 25 3 pale liver 2.52566960537523e-09 1.93310865949873e-07 2.10153374233129 0.5 25.3 25 3 lethality throughout fetal growth and development, complete penetrance 1.20799753274362e-21 6.67754191711055e-19 2.10153374233129 0.5 25.3 25 3 abnormal cell morphology 1.39233550652268e-13 2.88619547706265e-11 2.10153374233129 0.5 25.3 25 3 small liver 9.44358392543574e-10 8.86449623189487e-08 2.10153374233129 0.5 25.3 25 3 decreased mean corpuscular hemoglobin 1.10699013328186e-08 7.8675370186818e-07 2.10153374233129 0.5 25.3 25 3 abnormal vertebral body morphology 8.67510445120061e-05 0.00197975434150106 2.10153374233129 0.5 25.3 25 3 heart inflammation 0.000400265848410569 0.00689038960499163 2.10153374233129 0.5 25.3 25 3 ocular hypertelorism 0.000669424671052967 0.0103107979519768 2.10153374233129 0.5 25.3 25 3 abnormal truncus arteriosus septation 0.000669424671052967 0.0103107979519768 2.10153374233129 0.5 25.3 25 3 increased myocardial infarction size 0.00112287398281675 0.015221520611753 2.10153374233129 0.5 25.3 25 3 abnormal cochlear sensory epithelium morphology 0.00112287398281675 0.015221520611753 2.10153374233129 0.5 25.3 25 3 abnormal cerebral cortex pyramidal cell morphology 0.00112287398281675 0.015221520611753 2.10153374233129 0.5 25.3 25 3 increased adenoma incidence 0.00112287398281675 0.015221520611753 2.10153374233129 0.5 25.3 25 3 embryonic lethality before implantation, incomplete penetrance 0.00112287398281675 0.015221520611753 2.10153374233129 0.5 25.3 25 3 spleen atrophy 0.00189004043547483 0.0222291989751472 2.10153374233129 0.5 25.3 25 3 abnormal physiological neovascularization 0.00189004043547483 0.0222291989751472 2.10153374233129 0.5 25.3 25 3 abnormal neuron proliferation 0.00189004043547483 0.0222291989751472 2.10153374233129 0.5 25.3 25 3 blepharitis 0.00542755990103122 0.0504712345937015 2.10153374233129 0.5 25.3 25 3 kidney degeneration 0.00542755990103122 0.0504712345937015 2.10153374233129 0.5 25.3 25 3 failure of zygotic cell division 0.00928034569515907 0.0737535460597705 2.10153374233129 0.5 25.3 25 3 spina bifida occulta 0.00928034569515907 0.0737535460597705 2.10153374233129 0.5 25.3 25 3 testis degeneration 0.00928034569515907 0.0737535460597705 2.10153374233129 0.5 25.3 25 3 mesocardia 0.0159995237432149 0.10785586805216 2.10153374233129 0.5 25.3 25 3 myocarditis 0.0159995237432149 0.10785586805216 2.10153374233129 0.5 25.3 25 3 interstitial pneumonia 0.0159995237432149 0.10785586805216 2.10153374233129 0.5 25.3 25 3 abnormal embryonic growth/weight/body size 0.0159995237432149 0.10785586805216 2.10153374233129 0.5 25.3 25 3 abnormal gastrocnemius morphology 0.0159995237432149 0.10785586805216 2.10153374233129 0.5 25.3 25 3 abnormal vascular endothelial cell development 0.0159995237432149 0.10785586805216 2.10153374233129 0.5 25.3 25 3 increased hepatocyte proliferation 0.0159995237432149 0.10785586805216 2.10153374233129 0.5 25.3 25 3 abnormal palatine bone morphology 0.0159995237432149 0.10785586805216 2.10153374233129 0.5 25.3 25 3 hydrometra 0.0159995237432149 0.10785586805216 2.10153374233129 0.5 25.3 25 3 increased skeletal muscle glycogen level 0.0159995237432149 0.10785586805216 2.10153374233129 0.5 25.3 25 3 abnormal vitelline vein connection 0.0159995237432149 0.10785586805216 2.10153374233129 0.5 25.3 25 3 abnormal otic capsule morphology 0.0278896278108557 0.155202347157726 2.10153374233129 0.5 25.3 25 3 increased cranium width 0.0278896278108557 0.155202347157726 2.10153374233129 0.5 25.3 25 3 fused cornea and lens 0.0278896278108557 0.155202347157726 2.10153374233129 0.5 25.3 25 3 decreased circulating parathyroid hormone level 0.0278896278108557 0.155202347157726 2.10153374233129 0.5 25.3 25 3 abnormal tibialis anterior morphology 0.0278896278108557 0.155202347157726 2.10153374233129 0.5 25.3 25 3 peritoneal inflammation 0.0278896278108557 0.155202347157726 2.10153374233129 0.5 25.3 25 3 abnormal plasma membrane morphology 0.0278896278108557 0.155202347157726 2.10153374233129 0.5 25.3 25 3 abnormal respiratory conducting tube morphology 0.0278896278108557 0.155202347157726 2.10153374233129 0.5 25.3 25 3 tachypnea 0.0278896278108557 0.155202347157726 2.10153374233129 0.5 25.3 25 3 increased serotonin level 0.0278896278108557 0.155202347157726 2.10153374233129 0.5 25.3 25 3 increased circulating fructosamine level 0.0278896278108557 0.155202347157726 2.10153374233129 0.5 25.3 25 3 abnormal heart and great artery attachment 0.0278896278108557 0.155202347157726 2.10153374233129 0.5 25.3 25 3 abnormal left subclavian artery morphology 0.0278896278108557 0.155202347157726 2.10153374233129 0.5 25.3 25 3 decreased macrophage cytokine production 0.0278896278108557 0.155202347157726 2.10153374233129 0.5 25.3 25 3 decreased macrophage apoptosis 0.0278896278108557 0.155202347157726 2.10153374233129 0.5 25.3 25 3 decreased circulating lactate level 0.0278896278108557 0.155202347157726 2.10153374233129 0.5 25.3 25 3 abnormal lysosome morphology 3.15773682578558e-05 0.000829864426489531 2.10153374233129 0.5 25.3 25 3 abnormal redox activity 0.00319467583681305 0.0325686727216085 2.10153374233129 0.5 25.3 25 3 abnormal body wall morphology 0.00319467583681305 0.0325686727216085 2.10153374233129 0.5 25.3 25 3 decreased tumor latency 0.00319467583681305 0.0325686727216085 2.10153374233129 0.5 25.3 25 3 double outlet right ventricle 1.58817674186191e-12 2.72454458302172e-10 2.08189324006651 0.495327102803738 25.3 25 3 abnormal placenta labyrinth morphology 1.51933919998408e-09 1.30322629653807e-07 2.07493204939039 0.493670886075949 25.3 25 3 hemorrhage 1.75921172876109e-25 1.25029690722663e-22 2.07470565200365 0.493617021276596 25.3 25 3 increased circulating bilirubin level 9.29114741832111e-07 4.09057154036704e-05 2.0618821622873 0.490566037735849 25.3 25 3 abnormal cell migration 6.8013422054226e-06 0.000222609720210378 2.0548329925017 0.488888888888889 25.3 25 3 edema 1.70964420817822e-18 6.07534281120473e-16 2.05266086460265 0.488372093023256 25.3 25 3 abnormal cell differentiation 1.84888361657009e-05 0.000539846709547321 2.05027682178662 0.48780487804878 25.3 25 3 hemopericardium 1.84888361657009e-05 0.000539846709547321 2.05027682178662 0.48780487804878 25.3 25 3 increased hepatocyte apoptosis 3.05283098778584e-05 0.000810345462821878 2.04764826175869 0.487179487179487 25.3 25 3 abnormal dermal layer morphology 8.3521251340186e-05 0.00195194754521021 2.04148992112182 0.485714285714286 25.3 25 3 increased carcinoma incidence 8.3521251340186e-05 0.00195194754521021 2.04148992112182 0.485714285714286 25.3 25 3 abnormal artery morphology 8.3521251340186e-05 0.00195194754521021 2.04148992112182 0.485714285714286 25.3 25 3 inner cell mass degeneration 0.000229780296713656 0.00448296853392328 2.03374233128834 0.483870967741935 25.3 25 3 abnormal podocyte morphology 0.000229780296713656 0.00448296853392328 2.03374233128834 0.483870967741935 25.3 25 3 abnormal parietal bone morphology 0.000382099077091978 0.0066934609455373 2.02906706156124 0.482758620689655 25.3 25 3 abnormal lung development 1.42372815960195e-09 1.26482992750352e-07 2.02736196319018 0.482352941176471 25.3 25 3 pale yolk sac 2.3241071247766e-09 1.83530681678787e-07 2.02557469140365 0.481927710843373 25.3 25 3 rectal prolapse 0.000636667665836627 0.010027842379425 2.02369915928198 0.481481481481481 25.3 25 3 abnormal somite development 6.19633670289775e-09 4.53334927895828e-07 2.02172866350858 0.481012658227848 25.3 25 3 pallor 6.62143392065137e-18 1.93774316207298e-15 2.01747239263804 0.48 25.3 25 3 abnormal interventricular septum morphology 3.94869555236742e-06 0.000140319716950199 2.01747239263804 0.48 25.3 25 3 spontaneous skin ulceration 0.00106329409352616 0.0147350643880018 2.01747239263804 0.48 25.3 25 3 atrial septal defect 1.06729990496643e-05 0.000336064368810633 2.01016271005602 0.478260869565217 25.3 25 3 fragile skeleton 0.00178056728438283 0.021553095473977 2.01016271005602 0.478260869565217 25.3 25 3 decreased blood urea nitrogen level 1.75654894876559e-05 0.000526435603621013 2.00600948131623 0.477272727272727 25.3 25 3 abnormal erythrocyte physiology 0.00299108666062931 0.0315268138487941 2.00146070698218 0.476190476190476 25.3 25 3 absent segment of posterior cerebral artery 0.00299108666062931 0.0315268138487941 2.00146070698218 0.476190476190476 25.3 25 3 increased muscle cell glucose uptake 0.00299108666062931 0.0315268138487941 2.00146070698218 0.476190476190476 25.3 25 3 increased embryonic tissue cell apoptosis 1.56916944575408e-08 1.04911137454039e-06 1.99376278118609 0.474358974358974 25.3 25 3 abnormal frontal bone morphology 7.86998076564324e-05 0.00187335666550599 1.99092670326122 0.473684210526316 25.3 25 3 maternal imprinting 0.00504338541623059 0.0480667479803586 1.99092670326122 0.473684210526316 25.3 25 3 small spleen 1.28655041341415e-09 1.18529413087693e-07 1.98606485539001 0.472527472527473 25.3 25 3 abnormal retinal blood vessel morphology 0.000129997357255955 0.00274130443019887 1.98478186775733 0.472222222222222 25.3 25 3 atrioventricular septal defect 3.72097970005646e-06 0.000134144014549137 1.98257900219933 0.471698113207547 25.3 25 3 enlarged liver sinusoidal spaces 0.000214981215820112 0.00422739742571169 1.97791411042945 0.470588235294118 25.3 25 3 abnormal interatrial septum morphology 0.00854226891282067 0.0696685046578407 1.97791411042945 0.470588235294118 25.3 25 3 abnormal tendon morphology 0.00854226891282067 0.0696685046578407 1.97791411042945 0.470588235294118 25.3 25 3 enhanced behavioral response to cocaine 0.00854226891282067 0.0696685046578407 1.97791411042945 0.470588235294118 25.3 25 3 abnormal vitelline vasculature morphology 1.4280501247498e-11 1.97348593628619e-09 1.97361429714591 0.469565217391304 25.3 25 3 decreased embryo size 2.90970030729377e-43 7.23787951439325e-40 1.96963831917242 0.468619246861925 25.3 25 3 small placenta 2.69841183596101e-05 0.000729597765429677 1.96143149284254 0.466666666666667 25.3 25 3 macrocytosis 0.0145489515268739 0.102929948298112 1.96143149284254 0.466666666666667 25.3 25 3 decreased hepatocyte number 0.0145489515268739 0.102929948298112 1.96143149284254 0.466666666666667 25.3 25 3 abnormal cricoid cartilage morphology 0.0145489515268739 0.102929948298112 1.96143149284254 0.466666666666667 25.3 25 3 abnormal lymph node B cell domain morphology 0.0145489515268739 0.102929948298112 1.96143149284254 0.466666666666667 25.3 25 3 arthritis 0.0145489515268739 0.102929948298112 1.96143149284254 0.466666666666667 25.3 25 3 abnormal placenta size 0.0145489515268739 0.102929948298112 1.96143149284254 0.466666666666667 25.3 25 3 abnormal trophectoderm morphology 0.0145489515268739 0.102929948298112 1.96143149284254 0.466666666666667 25.3 25 3 shortened head 0.000980505834486936 0.0138654557666293 1.95142418930762 0.464285714285714 25.3 25 3 lymphoid hyperplasia 0.000980505834486936 0.0138654557666293 1.95142418930762 0.464285714285714 25.3 25 3 small superior cervical ganglion 0.000980505834486936 0.0138654557666293 1.95142418930762 0.464285714285714 25.3 25 3 abnormal somite shape 0.000980505834486936 0.0138654557666293 1.95142418930762 0.464285714285714 25.3 25 3 abnormal renal tubule epithelium morphology 0.000980505834486936 0.0138654557666293 1.95142418930762 0.464285714285714 25.3 25 3 lethality throughout fetal growth and development, incomplete penetrance 1.40123304222945e-16 3.48556719254576e-14 1.94890838674298 0.463687150837989 25.3 25 3 ventricular septal defect 6.38362270996752e-13 1.1762415919292e-10 1.94700920245399 0.463235294117647 25.3 25 3 extramedullary hematopoiesis 2.44985956026299e-10 2.64957637224096e-08 1.94292742215534 0.462264150943396 25.3 25 3 absent common myeloid progenitor cells 0.0249528246419067 0.144020875247524 1.9398773006135 0.461538461538462 25.3 25 3 absent trabeculae carneae 0.0249528246419067 0.144020875247524 1.9398773006135 0.461538461538462 25.3 25 3 increased foot pad pigmentation 0.0249528246419067 0.144020875247524 1.9398773006135 0.461538461538462 25.3 25 3 abnormal telomere length 0.0249528246419067 0.144020875247524 1.9398773006135 0.461538461538462 25.3 25 3 small otic vesicle 0.0249528246419067 0.144020875247524 1.9398773006135 0.461538461538462 25.3 25 3 abnormal branching of the mammary ductal tree 0.00019760083603623 0.00394804883245079 1.9311391145747 0.459459459459459 25.3 25 3 abnormal chromosome morphology 0.00019760083603623 0.00394804883245079 1.9311391145747 0.459459459459459 25.3 25 3 overriding aortic valve 2.484183644686e-05 0.00068280738300071 1.92640593047035 0.458333333333333 25.3 25 3 abnormal digestive system morphology 0.00272076488027732 0.0289226608533753 1.92640593047035 0.458333333333333 25.3 25 3 abnormal neural tube closure 3.37047723017459e-08 2.09601552751482e-06 1.92429595683347 0.457831325301205 25.3 25 3 abnormal liver development 0.000325684343803209 0.00589192585607623 1.92140227870289 0.457142857142857 25.3 25 3 thick pulmonary interalveolar septum 0.000325684343803209 0.00589192585607623 1.92140227870289 0.457142857142857 25.3 25 3 decreased bone mineralization 0.000325684343803209 0.00589192585607623 1.92140227870289 0.457142857142857 25.3 25 3 abnormal craniofacial bone morphology 5.20744383667313e-06 0.000173872705284891 1.91718867721451 0.456140350877193 25.3 25 3 pericardial edema 6.76878809414855e-07 3.08942392370542e-05 1.91610429447853 0.455882352941176 25.3 25 3 abnormal placenta morphology 8.89092288762193e-08 4.91470459621324e-06 1.91532189174497 0.455696202531646 25.3 25 3 thin ventricular wall 1.17653134424992e-08 8.24400484175122e-07 1.91473074301295 0.455555555555556 25.3 25 3 anemia 3.03114409826893e-18 9.85204450771421e-16 1.91229610676591 0.454976303317536 25.3 25 3 abnormal platelet physiology 8.49626510123589e-06 0.000272702702442894 1.91048522030117 0.454545454545455 25.3 25 3 abnormal epidermis stratum basale morphology 0.000537280131313149 0.00882167872370599 1.91048522030117 0.454545454545455 25.3 25 3 abnormal basisphenoid bone morphology 0.00454793055880646 0.0437639352612421 1.91048522030117 0.454545454545455 25.3 25 3 abnormal germ layer development 0.00454793055880646 0.0437639352612421 1.91048522030117 0.454545454545455 25.3 25 3 intracerebral hemorrhage 0.00454793055880646 0.0437639352612421 1.91048522030117 0.454545454545455 25.3 25 3 aphakia 0.00454793055880646 0.0437639352612421 1.91048522030117 0.454545454545455 25.3 25 3 abnormal vascular branching morphogenesis 0.00454793055880646 0.0437639352612421 1.91048522030117 0.454545454545455 25.3 25 3 decreased cardiac output 0.00454793055880646 0.0437639352612421 1.91048522030117 0.454545454545455 25.3 25 3 abnormal retinal layer morphology 0.00454793055880646 0.0437639352612421 1.91048522030117 0.454545454545455 25.3 25 3 increased mammary gland tumor incidence 0.00454793055880646 0.0437639352612421 1.91048522030117 0.454545454545455 25.3 25 3 premature suture closure 0.0431851259501098 0.202684907171506 1.91048522030117 0.454545454545455 25.3 25 3 decreased atrioventricular cushion size 0.0431851259501098 0.202684907171506 1.91048522030117 0.454545454545455 25.3 25 3 increased mast cell number 0.0431851259501098 0.202684907171506 1.91048522030117 0.454545454545455 25.3 25 3 abnormal glossopharyngeal ganglion morphology 0.0431851259501098 0.202684907171506 1.91048522030117 0.454545454545455 25.3 25 3 abnormal proximal-distal axis patterning 0.0431851259501098 0.202684907171506 1.91048522030117 0.454545454545455 25.3 25 3 pathological neovascularization 0.0431851259501098 0.202684907171506 1.91048522030117 0.454545454545455 25.3 25 3 increased glycogen level 0.0431851259501098 0.202684907171506 1.91048522030117 0.454545454545455 25.3 25 3 abnormal palate development 0.0431851259501098 0.202684907171506 1.91048522030117 0.454545454545455 25.3 25 3 palatal shelf hypoplasia 0.0431851259501098 0.202684907171506 1.91048522030117 0.454545454545455 25.3 25 3 abnormal palatal shelf elevation 0.0431851259501098 0.202684907171506 1.91048522030117 0.454545454545455 25.3 25 3 decreased palatine bone horizontal plate size 0.0431851259501098 0.202684907171506 1.91048522030117 0.454545454545455 25.3 25 3 abnormal extraembryonic ectoderm morphology 0.0431851259501098 0.202684907171506 1.91048522030117 0.454545454545455 25.3 25 3 abnormal pulmonary alveolar sac morphology 0.0431851259501098 0.202684907171506 1.91048522030117 0.454545454545455 25.3 25 3 thin hypoglossal nerve 0.0431851259501098 0.202684907171506 1.91048522030117 0.454545454545455 25.3 25 3 abnormal neurocranium morphology 2.3446041063973e-07 1.21504223222152e-05 1.90539059304703 0.453333333333333 25.3 25 3 abnormal cell cycle 1.91777698488224e-10 2.21882337204398e-08 1.90051747132569 0.452173913043478 25.3 25 3 prenatal lethality 2.91553706592568e-06 0.000109884825022578 1.89815950920245 0.451612903225806 25.3 25 3 abnormal postnatal growth/weight/body size 0.000887230945644574 0.0130590945401827 1.89815950920245 0.451612903225806 25.3 25 3 failure of chorioallantoic fusion 2.26250619714925e-05 0.000639543655160086 1.89550102249489 0.450980392156863 25.3 25 3 increased monocyte cell number 3.7541830530146e-09 2.78762099832054e-07 1.89138036809816 0.45 25.3 25 3 absent placental labyrinth 0.00762339494593983 0.0631054739701342 1.89138036809816 0.45 25.3 25 3 abnormal heart right ventricle morphology 0.00762339494593983 0.0631054739701342 1.89138036809816 0.45 25.3 25 3 abnormal optic stalk morphology 0.00762339494593983 0.0631054739701342 1.89138036809816 0.45 25.3 25 3 abnormal eating behavior 4.74350527531699e-06 0.000161636566744534 1.89138036809816 0.45 25.3 25 3 abnormal sternum morphology 1.00330289686528e-06 4.26618112128613e-05 1.88833466702232 0.449275362318841 25.3 25 3 increased T cell derived lymphoma incidence 3.69270568859582e-05 0.000951876207293482 1.88709152372605 0.448979591836735 25.3 25 3 abnormal blood vessel morphology 1.78522172561411e-12 2.96049269497674e-10 1.88413370002115 0.448275862068966 25.3 25 3 thrombocytosis 7.71721937636016e-06 0.000250935728087528 1.88413370002115 0.448275862068966 25.3 25 3 decreased trophoblast giant cell number 0.00146671132487034 0.0183338915608792 1.88413370002115 0.448275862068966 25.3 25 3 abnormal outer ear morphology 0.00146671132487034 0.0183338915608792 1.88413370002115 0.448275862068966 25.3 25 3 persistence of hyaloid vascular system 0.000293854049486545 0.00546108084566632 1.88031966419115 0.447368421052632 25.3 25 3 abnormal heart valve morphology 0.00242755309957042 0.0266014904633542 1.86802999318337 0.444444444444444 25.3 25 3 abnormal bone trabecula morphology 0.00242755309957042 0.0266014904633542 1.86802999318337 0.444444444444444 25.3 25 3 decreased bone ossification 0.00242755309957042 0.0266014904633542 1.86802999318337 0.444444444444444 25.3 25 3 trabecula carnea hypoplasia 9.83976114865934e-05 0.00218962948387633 1.86802999318337 0.444444444444444 25.3 25 3 abnormal pharyngeal arch morphology 0.000482233933041008 0.00799704605626339 1.86802999318337 0.444444444444444 25.3 25 3 eye inflammation 0.0128203433736267 0.0937958945349898 1.86802999318337 0.444444444444444 25.3 25 3 abnormal Peyer's patch follicle morphology 0.0128203433736267 0.0937958945349898 1.86802999318337 0.444444444444444 25.3 25 3 abnormal bile duct morphology 0.0128203433736267 0.0937958945349898 1.86802999318337 0.444444444444444 25.3 25 3 long tibia 0.0128203433736267 0.0937958945349898 1.86802999318337 0.444444444444444 25.3 25 3 abnormal glycogen homeostasis 0.0128203433736267 0.0937958945349898 1.86802999318337 0.444444444444444 25.3 25 3 decreased lactate dehydrogenase level 0.0128203433736267 0.0937958945349898 1.86802999318337 0.444444444444444 25.3 25 3 abnormal pregnancy 0.0128203433736267 0.0937958945349898 1.86802999318337 0.444444444444444 25.3 25 3 increased gastrointestinal tumor incidence 0.0128203433736267 0.0937958945349898 1.86802999318337 0.444444444444444 25.3 25 3 increased effector memory CD8-positive, alpha-beta T cell number 0.0128203433736267 0.0937958945349898 1.86802999318337 0.444444444444444 25.3 25 3 decreased B cell proliferation 3.12780849891408e-07 1.55608472820976e-05 1.86211850586317 0.443037974683544 25.3 25 3 embryonic lethality between somite formation and embryo turning, complete penetrance 1.47012905883403e-06 5.94625371357665e-05 1.86135845749343 0.442857142857143 25.3 25 3 thrombocytopenia 6.13063127942824e-12 8.97055606328103e-10 1.85514702771314 0.441379310344828 25.3 25 3 short maxilla 0.000791726643544495 0.0117929342863289 1.85429447852761 0.441176470588235 25.3 25 3 overexpanded pulmonary alveoli 0.000791726643544495 0.0117929342863289 1.85429447852761 0.441176470588235 25.3 25 3 embryonic lethality before implantation, complete penetrance 2.09719150217785e-10 2.31856171629662e-08 1.84934969325153 0.44 25.3 25 3 abnormal cochlear outer hair cell morphology 0.00402306335558179 0.0397907359722056 1.84934969325153 0.44 25.3 25 3 decreased birth body size 1.55907315356213e-09 1.31464219304603e-07 1.8434506511678 0.43859649122807 25.3 25 3 absent vitelline blood vessels 1.82942133828749e-05 0.000539846709547321 1.8434506511678 0.43859649122807 25.3 25 3 increased hepatocellular carcinoma incidence 1.82942133828749e-05 0.000539846709547321 1.8434506511678 0.43859649122807 25.3 25 3 abnormal neural tube morphology 6.72728722027651e-13 1.19529478288842e-10 1.84208513216693 0.438271604938272 25.3 25 3 decreased mast cell number 0.0216433672358626 0.133097344868253 1.83884202453988 0.4375 25.3 25 3 disorganized yolk sac vascular plexus 0.0216433672358626 0.133097344868253 1.83884202453988 0.4375 25.3 25 3 abnormal epicardium morphology 0.0216433672358626 0.133097344868253 1.83884202453988 0.4375 25.3 25 3 abnormal pulmonary elastic fiber morphology 0.0216433672358626 0.133097344868253 1.83884202453988 0.4375 25.3 25 3 large intestinal inflammation 0.0216433672358626 0.133097344868253 1.83884202453988 0.4375 25.3 25 3 increased pancreatic beta cell number 0.0216433672358626 0.133097344868253 1.83884202453988 0.4375 25.3 25 3 small pancreas 0.0216433672358626 0.133097344868253 1.83884202453988 0.4375 25.3 25 3 increased cochlear outer hair cell number 0.0216433672358626 0.133097344868253 1.83884202453988 0.4375 25.3 25 3 abnormal amnion morphology 0.0216433672358626 0.133097344868253 1.83884202453988 0.4375 25.3 25 3 loose skin 0.0216433672358626 0.133097344868253 1.83884202453988 0.4375 25.3 25 3 abnormal thoracic cage shape 0.0216433672358626 0.133097344868253 1.83884202453988 0.4375 25.3 25 3 dilated respiratory conducting tubes 0.0216433672358626 0.133097344868253 1.83884202453988 0.4375 25.3 25 3 abnormal pulmonary alveolus wall morphology 0.0216433672358626 0.133097344868253 1.83884202453988 0.4375 25.3 25 3 decreased circulating total protein level 2.96546771496478e-05 0.000793182896879022 1.83406581148912 0.436363636363636 25.3 25 3 embryonic lethality during organogenesis, complete penetrance 2.57582562022772e-40 4.27157748687764e-37 1.83133654688869 0.435714285714286 25.3 25 3 pericardial effusion 1.00735957847555e-05 0.000319211076618844 1.83036809815951 0.435483870967742 25.3 25 3 prenatal lethality, complete penetrance 1.2662022917727e-20 5.72668763779017e-18 1.82939268217328 0.435251798561151 25.3 25 3 perimembraneous ventricular septal defect 3.43849545671919e-06 0.000124865072242175 1.82742064550547 0.434782608695652 25.3 25 3 failure to gastrulate 0.000142791575260923 0.0029974180882831 1.82742064550547 0.434782608695652 25.3 25 3 abnormal blood vessel physiology 0.00667667153913233 0.0584796494844777 1.82742064550547 0.434782608695652 25.3 25 3 abnormal pulmonary artery morphology 0.00667667153913233 0.0584796494844777 1.82742064550547 0.434782608695652 25.3 25 3 increased erythrocyte cell number 1.62828765024808e-05 0.000490953397574801 1.82132924335378 0.433333333333333 25.3 25 3 abnormal brain vasculature morphology 0.00213689464732462 0.024271805640274 1.82132924335378 0.433333333333333 25.3 25 3 decreased hemoglobin content 5.2566363157459e-11 6.37847943191119e-09 1.81834834442849 0.432624113475177 25.3 25 3 increased erythroid progenitor cell number 0.000699097245044651 0.0106036853478571 1.8175426960703 0.432432432432432 25.3 25 3 muscular atrophy 0.000232067988920743 0.00450991501906522 1.81496095928611 0.431818181818182 25.3 25 3 small lung 7.78356265223407e-05 0.00186169347090695 1.81308793456033 0.431372549019608 25.3 25 3 abnormal nervous system morphology 1.04728410231251e-06 4.41545627881757e-05 1.80891511998136 0.430379746835443 25.3 25 3 abnormal brainstem morphology 0.00351283854838302 0.0353058015721324 1.80131463628396 0.428571428571429 25.3 25 3 abnormal blood flow velocity 0.0367071838519673 0.180853387173316 1.80131463628396 0.428571428571429 25.3 25 3 intestinal obstruction 0.0367071838519673 0.180853387173316 1.80131463628396 0.428571428571429 25.3 25 3 abnormal vascular endothelial cell migration 0.0367071838519673 0.180853387173316 1.80131463628396 0.428571428571429 25.3 25 3 lysosomal protein accumulation 0.0367071838519673 0.180853387173316 1.80131463628396 0.428571428571429 25.3 25 3 abnormal viscerocranium morphology 0.0367071838519673 0.180853387173316 1.80131463628396 0.428571428571429 25.3 25 3 sternebra fusion 0.0367071838519673 0.180853387173316 1.80131463628396 0.428571428571429 25.3 25 3 pulmonary alveolar hemorrhage 0.0367071838519673 0.180853387173316 1.80131463628396 0.428571428571429 25.3 25 3 decreased compact bone area 0.0367071838519673 0.180853387173316 1.80131463628396 0.428571428571429 25.3 25 3 embryonic lethality between implantation and somite formation, complete penetrance 1.63552953542015e-17 4.52042191039736e-15 1.80131463628396 0.428571428571429 25.3 25 3 abnormal hippocampus pyramidal cell morphology 0.00114125836835046 0.0153452983311987 1.80131463628396 0.428571428571429 25.3 25 3 skin edema 0.000377033829937145 0.0066830151998699 1.80131463628396 0.428571428571429 25.3 25 3 abnormal hematopoietic system physiology 0.0110976261599227 0.084162637417097 1.80131463628396 0.428571428571429 25.3 25 3 abnormal tumor vascularization 0.0110976261599227 0.084162637417097 1.80131463628396 0.428571428571429 25.3 25 3 decreased circulating alanine transaminase level 7.9021370474436e-06 0.000255280076695013 1.79248466257669 0.426470588235294 25.3 25 3 hepatic necrosis 0.000203914193074543 0.00405789244218341 1.78853935517556 0.425531914893617 25.3 25 3 decreased bone marrow cell number 4.33568391962132e-06 0.000149791857639695 1.78486427430877 0.424657534246575 25.3 25 3 abnormal fertility/fecundity 4.33568391962132e-06 0.000149791857639695 1.78486427430877 0.424657534246575 25.3 25 3 decreased percent body fat/body weight 4.33568391962132e-06 0.000149791857639695 1.78486427430877 0.424657534246575 25.3 25 3 decreased circulating serum albumin level 9.72374137222602e-08 5.3160014644862e-06 1.78311953894776 0.424242424242424 25.3 25 3 abnormal aorta morphology 0.00186274074398338 0.0220646076221841 1.78311953894776 0.424242424242424 25.3 25 3 enlarged pericardium 0.00186274074398338 0.0220646076221841 1.78311953894776 0.424242424242424 25.3 25 3 decreased brown adipose tissue amount 0.00186274074398338 0.0220646076221841 1.78311953894776 0.424242424242424 25.3 25 3 distended pericardium 0.000110556439067976 0.00241208283511828 1.77822085889571 0.423076923076923 25.3 25 3 abnormal xiphoid process morphology 0.00577680020320708 0.0516898939045957 1.77822085889571 0.423076923076923 25.3 25 3 abnormal stomach morphology 0.00577680020320708 0.0516898939045957 1.77822085889571 0.423076923076923 25.3 25 3 thick skin 0.00577680020320708 0.0516898939045957 1.77822085889571 0.423076923076923 25.3 25 3 increased leukemia incidence 0.00577680020320708 0.0516898939045957 1.77822085889571 0.423076923076923 25.3 25 3 oxidative stress 4.50190078104904e-07 2.13304346530657e-05 1.7746284935242 0.422222222222222 25.3 25 3 abnormal compact bone morphology 0.000993819569086907 0.0139668145655575 1.76971262512109 0.421052631578947 25.3 25 3 enlarged adrenal glands 0.0184763127971876 0.11891287990428 1.76971262512109 0.421052631578947 25.3 25 3 small superior vagus ganglion 0.0184763127971876 0.11891287990428 1.76971262512109 0.421052631578947 25.3 25 3 thin dermal layer 0.0184763127971876 0.11891287990428 1.76971262512109 0.421052631578947 25.3 25 3 increased malignant tumor incidence 0.0184763127971876 0.11891287990428 1.76971262512109 0.421052631578947 25.3 25 3 decreased germ cell number 0.0184763127971876 0.11891287990428 1.76971262512109 0.421052631578947 25.3 25 3 abnormal optic vesicle formation 0.0184763127971876 0.11891287990428 1.76971262512109 0.421052631578947 25.3 25 3 abnormal blastocyst morphology 0.0184763127971876 0.11891287990428 1.76971262512109 0.421052631578947 25.3 25 3 Leydig cell hypoplasia 0.0184763127971876 0.11891287990428 1.76971262512109 0.421052631578947 25.3 25 3 increased liver cholesterol level 0.0184763127971876 0.11891287990428 1.76971262512109 0.421052631578947 25.3 25 3 decreased susceptibility to weight gain 0.0184763127971876 0.11891287990428 1.76971262512109 0.421052631578947 25.3 25 3 abnormal facial morphology 6.00694615564165e-05 0.00150173653891041 1.76971262512108 0.421052631578947 25.3 25 3 pale kidney 0.00303942954298244 0.0316927765826255 1.76257668711656 0.419354838709677 25.3 25 3 small cranium 0.00303942954298244 0.0316927765826255 1.76257668711656 0.419354838709677 25.3 25 3 abnormal T-helper 2 physiology 9.65127516072257e-05 0.00216284206867544 1.75764640267708 0.418181818181818 25.3 25 3 absent mesoderm 5.24058165780309e-05 0.0013234463831254 1.75127811860941 0.416666666666667 25.3 25 3 decreased body height 0.00950231915260018 0.0741199601057183 1.75127811860941 0.416666666666667 25.3 25 3 abnormal osteoblast morphology 0.00950231915260018 0.0741199601057183 1.75127811860941 0.416666666666667 25.3 25 3 increased body temperature 0.00950231915260018 0.0741199601057183 1.75127811860941 0.416666666666667 25.3 25 3 abnormal glossopharyngeal nerve morphology 0.062603413240749 0.259759783880506 1.75127811860941 0.416666666666667 25.3 25 3 abnormal mating frequency 0.062603413240749 0.259759783880506 1.75127811860941 0.416666666666667 25.3 25 3 increased growth rate 0.062603413240749 0.259759783880506 1.75127811860941 0.416666666666667 25.3 25 3 abnormal AMPA-mediated synaptic currents 0.062603413240749 0.259759783880506 1.75127811860941 0.416666666666667 25.3 25 3 loss of dopaminergic neurons 0.062603413240749 0.259759783880506 1.75127811860941 0.416666666666667 25.3 25 3 dilated bile duct 0.062603413240749 0.259759783880506 1.75127811860941 0.416666666666667 25.3 25 3 increased osteosarcoma incidence 0.062603413240749 0.259759783880506 1.75127811860941 0.416666666666667 25.3 25 3 decreased left ventricle systolic pressure 0.062603413240749 0.259759783880506 1.75127811860941 0.416666666666667 25.3 25 3 vestibular saccular macula degeneration 0.062603413240749 0.259759783880506 1.75127811860941 0.416666666666667 25.3 25 3 abnormal B cell proliferation 0.062603413240749 0.259759783880506 1.75127811860941 0.416666666666667 25.3 25 3 decreased red blood cell distribution width 0.062603413240749 0.259759783880506 1.75127811860941 0.416666666666667 25.3 25 3 increased fibrosarcoma incidence 0.062603413240749 0.259759783880506 1.75127811860941 0.416666666666667 25.3 25 3 persistent right dorsal aorta 0.062603413240749 0.259759783880506 1.75127811860941 0.416666666666667 25.3 25 3 abnormal colon goblet cell morphology 0.062603413240749 0.259759783880506 1.75127811860941 0.416666666666667 25.3 25 3 heart right ventricle hypertrophy 0.00161199010785721 0.0198506207588852 1.75127811860941 0.416666666666667 25.3 25 3 increased spleen weight 3.63631830575475e-08 2.23341772483085e-06 1.74817851131983 0.415929203539823 25.3 25 3 increased bone trabecula number 0.000860227488006692 0.0127750201577113 1.74273529851863 0.414634146341463 25.3 25 3 increased mean corpuscular hemoglobin 3.02722475050969e-07 1.52698186384998e-05 1.74066431182996 0.414141414141414 25.3 25 3 abnormal embryonic neuroepithelium morphology 8.390172550431e-05 0.00195194754521021 1.73920033848107 0.413793103448276 25.3 25 3 blood in lymph vessels 0.00495716364733316 0.047335679741809 1.73920033848107 0.413793103448276 25.3 25 3 abnormal forelimb morphology 0.000461313655908492 0.00770146120182801 1.73604961323019 0.41304347826087 25.3 25 3 abnormal direction of heart looping 0.00261245061429059 0.0278307105055583 1.73067484662577 0.411764705882353 25.3 25 3 abnormal bone marrow cavity morphology 0.0308141360619919 0.165194317789234 1.73067484662577 0.411764705882353 25.3 25 3 abnormal urinary bladder morphology 0.0308141360619919 0.165194317789234 1.73067484662577 0.411764705882353 25.3 25 3 abnormal cranial suture morphology 0.0308141360619919 0.165194317789234 1.73067484662577 0.411764705882353 25.3 25 3 abnormal embryonic-extraembryonic boundary morphology 0.0308141360619919 0.165194317789234 1.73067484662577 0.411764705882353 25.3 25 3 prenatal lethality, incomplete penetrance 9.02430291434055e-19 3.4535313076034e-16 1.72823498546981 0.411184210526316 25.3 25 3 decreased hematocrit 8.93546419561484e-10 8.86449623189487e-08 1.72728800739558 0.410958904109589 25.3 25 3 increased vascular permeability 0.00138729140653056 0.0175171947905825 1.72433537832311 0.41025641025641 25.3 25 3 failure of heart looping 0.00138729140653056 0.0175171947905825 1.72433537832311 0.41025641025641 25.3 25 3 abnormal long bone morphology 7.26799020319318e-05 0.00175525491557699 1.72256864125515 0.409836065573771 25.3 25 3 abnormal enterocyte morphology 0.0156320308068494 0.107713785684315 1.71943669827105 0.409090909090909 25.3 25 3 abnormal facial nerve morphology 0.0156320308068494 0.107713785684315 1.71943669827105 0.409090909090909 25.3 25 3 increased skin papilloma incidence 0.0156320308068494 0.107713785684315 1.71943669827105 0.409090909090909 25.3 25 3 abnormal lysosome physiology 0.0156320308068494 0.107713785684315 1.71943669827105 0.409090909090909 25.3 25 3 cleft upper lip 0.0156320308068494 0.107713785684315 1.71943669827105 0.409090909090909 25.3 25 3 decreased circulating estradiol level 0.0156320308068494 0.107713785684315 1.71943669827105 0.409090909090909 25.3 25 3 failure of palatal shelf elevation 0.0156320308068494 0.107713785684315 1.71943669827105 0.409090909090909 25.3 25 3 abnormal craniofacial development 0.000397730330823297 0.00687051526335383 1.71553774884187 0.408163265306122 25.3 25 3 decreased erythrocyte cell number 3.73648601039354e-10 3.95511019185273e-08 1.7133523504357 0.407643312101911 25.3 25 3 abnormal maxilla morphology 0.000214285778057924 0.00422739742571169 1.71236082708475 0.407407407407407 25.3 25 3 decreased platelet aggregation 0.000214285778057924 0.00422739742571169 1.71236082708475 0.407407407407407 25.3 25 3 thin epidermis 0.0080794075869573 0.0666584622638683 1.71236082708475 0.407407407407407 25.3 25 3 increased circulating alkaline phosphatase level 2.06174409637559e-10 2.31856171629662e-08 1.71236082708475 0.407407407407407 25.3 25 3 increased hemoglobin content 0.000115819760218201 0.00250523176993718 1.7097223666424 0.406779661016949 25.3 25 3 polydipsia 0.00422927535841559 0.0415002858148275 1.70749616564417 0.40625 25.3 25 3 neonatal lethality 0.00422927535841559 0.0415002858148275 1.70749616564417 0.40625 25.3 25 3 abnormal embryonic hematopoiesis 0.00422927535841559 0.0415002858148275 1.70749616564417 0.40625 25.3 25 3 preweaning lethality, incomplete penetrance 9.98465542567062e-24 6.20920759283891e-21 1.70589047054765 0.405867970660147 25.3 25 3 increased granulocyte number 1.85555351422295e-05 0.000539846709547321 1.70394627756591 0.405405405405405 25.3 25 3 decreased cell proliferation 1.66217710991265e-11 2.17613976889879e-09 1.70394627756591 0.405405405405405 25.3 25 3 abnormal bone mineralization 5.2225503985552e-08 3.13038412443519e-06 1.70206865081377 0.40495867768595 25.3 25 3 disheveled coat 0.00118879917549399 0.0157714023948869 1.70124160093485 0.404761904761905 25.3 25 3 abnormal muscle morphology 0.00118879917549399 0.0157714023948869 1.70124160093485 0.404761904761905 25.3 25 3 anophthalmia 3.01931068601645e-06 0.000112097542260685 1.70011718480733 0.404494382022472 25.3 25 3 pulmonary hypoplasia 0.000635977577117236 0.010027842379425 1.69911238741679 0.404255319148936 25.3 25 3 eyelids open at birth 0.000341740269714172 0.00613775394161735 1.69739263803681 0.403846153846154 25.3 25 3 abnormal eye morphology 7.53667895378364e-09 5.43405475290922e-07 1.69332215209428 0.402877697841727 25.3 25 3 abnormal extraembryonic tissue morphology 7.81930181633325e-07 3.50459698524846e-05 1.68946830265849 0.401960784313726 25.3 25 3 abnormal embryonic tissue morphology 3.58986702519043e-09 2.70599825004884e-07 1.68694545302784 0.401360544217687 25.3 25 3 abnormal liver physiology 1.23009782625834e-06 5.0997805713627e-05 1.68122699386503 0.4 25.3 25 3 spleen hyperplasia 2.5270773131995e-05 0.000690780749075138 1.68122699386503 0.4 25.3 25 3 short stride length 0.000544114273943959 0.00884630232964442 1.68122699386503 0.4 25.3 25 3 abnormal circulating protein level 0.000544114273943959 0.00884630232964442 1.68122699386503 0.4 25.3 25 3 ruffled hair 0.0131551563506124 0.09568260649751 1.68122699386503 0.4 25.3 25 3 abnormal keratinocyte physiology 0.0131551563506124 0.09568260649751 1.68122699386503 0.4 25.3 25 3 increased cellular sensitivity to ionizing radiation 0.0131551563506124 0.09568260649751 1.68122699386503 0.4 25.3 25 3 small gonad 0.0257115913646861 0.147145947519711 1.68122699386503 0.4 25.3 25 3 decreased myocardial infarction size 0.0257115913646861 0.147145947519711 1.68122699386503 0.4 25.3 25 3 abnormal hyoid bone morphology 0.0257115913646861 0.147145947519711 1.68122699386503 0.4 25.3 25 3 decreased skin tensile strength 0.0257115913646861 0.147145947519711 1.68122699386503 0.4 25.3 25 3 dilated vasculature 0.0257115913646861 0.147145947519711 1.68122699386503 0.4 25.3 25 3 kidney atrophy 0.0257115913646861 0.147145947519711 1.68122699386503 0.4 25.3 25 3 abnormal sperm mitochondrial sheath morphology 0.0257115913646861 0.147145947519711 1.68122699386503 0.4 25.3 25 3 abnormal head morphology 0.000292801129025053 0.00546108084566632 1.68122699386503 0.4 25.3 25 3 abnormal myocardial trabeculae morphology 0.00101526829540363 0.01414834669365 1.68122699386503 0.4 25.3 25 3 albuminuria 0.00101526829540363 0.01414834669365 1.68122699386503 0.4 25.3 25 3 lethality at weaning, complete penetrance 0.00101526829540363 0.01414834669365 1.68122699386503 0.4 25.3 25 3 increased circulating serum albumin level 0.00359324544491736 0.0359686037997261 1.68122699386503 0.4 25.3 25 3 abnormal heart tube morphology 0.00683734298067219 0.0591396745355022 1.68122699386503 0.4 25.3 25 3 disorganized myocardium 0.00683734298067219 0.0591396745355022 1.68122699386503 0.4 25.3 25 3 abnormal microglial cell physiology 0.00683734298067219 0.0591396745355022 1.68122699386503 0.4 25.3 25 3 absent incisors 0.051479338735363 0.225138687671934 1.68122699386503 0.4 25.3 25 3 abnormal apical ectodermal ridge morphology 0.051479338735363 0.225138687671934 1.68122699386503 0.4 25.3 25 3 placental labyrinth hypoplasia 0.051479338735363 0.225138687671934 1.68122699386503 0.4 25.3 25 3 abnormal dendritic cell morphology 0.051479338735363 0.225138687671934 1.68122699386503 0.4 25.3 25 3 abnormal cerebral aqueduct morphology 0.051479338735363 0.225138687671934 1.68122699386503 0.4 25.3 25 3 abnormal secondary palate development 0.051479338735363 0.225138687671934 1.68122699386503 0.4 25.3 25 3 abnormal coronary vessel morphology 0.051479338735363 0.225138687671934 1.68122699386503 0.4 25.3 25 3 abnormal heart development 1.47473272382388e-09 1.28715707035506e-07 1.67590665527685 0.39873417721519 25.3 25 3 decreased lymphocyte cell number 5.28821564445189e-08 3.13200867037478e-06 1.67465970092025 0.3984375 25.3 25 3 perinatal lethality, incomplete penetrance 5.60104295491234e-13 1.07173802694957e-10 1.67378793637005 0.398230088495575 25.3 25 3 polydactyly 1.93261149824804e-06 7.63074778078096e-05 1.67264930512082 0.397959183673469 25.3 25 3 embryonic growth arrest 4.83063391742783e-13 9.61296149568138e-11 1.67021458997509 0.397379912663755 25.3 25 3 abnormal embryo development 2.50582119077027e-08 1.5982641569336e-06 1.66886503067485 0.397058823529412 25.3 25 3 abnormal placenta development 0.000464345311232468 0.00772614690094156 1.66536636184744 0.39622641509434 25.3 25 3 abnormal renal glomerulus morphology 7.81457642587427e-07 3.50459698524846e-05 1.65809084257331 0.394495412844037 25.3 25 3 perinatal lethality, complete penetrance 6.00715465007266e-12 8.97055606328103e-10 1.65754774043031 0.394366197183099 25.3 25 3 abnormal tooth development 0.00576752285779652 0.0516898939045957 1.65575385759435 0.393939393939394 25.3 25 3 abnormal skeleton physiology 0.00576752285779652 0.0516898939045957 1.65575385759435 0.393939393939394 25.3 25 3 dilated heart atrium 0.00576752285779652 0.0516898939045957 1.65575385759435 0.393939393939394 25.3 25 3 increased cardiomyocyte apoptosis 0.00576752285779652 0.0516898939045957 1.65575385759435 0.393939393939394 25.3 25 3 absent corpus callosum 0.011034246376623 0.0839378833695709 1.6512050832603 0.392857142857143 25.3 25 3 abnormal spleen germinal center morphology 0.011034246376623 0.0839378833695709 1.6512050832603 0.392857142857143 25.3 25 3 abnormal retinal inner nuclear layer morphology 0.011034246376623 0.0839378833695709 1.6512050832603 0.392857142857143 25.3 25 3 premature aging 0.011034246376623 0.0839378833695709 1.6512050832603 0.392857142857143 25.3 25 3 subcutaneous edema 0.011034246376623 0.0839378833695709 1.6512050832603 0.392857142857143 25.3 25 3 abnormal visceral yolk sac morphology 2.91687270276165e-05 0.000784402253850768 1.64930496233595 0.392405063291139 25.3 25 3 impaired balance 2.22733970796098e-06 8.65704300555145e-05 1.64826175869121 0.392156862745098 25.3 25 3 abnormal gluconeogenesis 0.000734912148181168 0.0110458850066505 1.64826175869121 0.392156862745098 25.3 25 3 abnormal trophoblast layer morphology 0.000734912148181168 0.0110458850066505 1.64826175869121 0.392156862745098 25.3 25 3 abnormal dendritic spine morphology 0.000734912148181168 0.0110458850066505 1.64826175869121 0.392156862745098 25.3 25 3 embryonic lethality, complete penetrance 8.60738895435643e-17 2.25377684462754e-14 1.64697001750101 0.391849529780564 25.3 25 3 increased insulin sensitivity 2.47888832154296e-08 1.5982641569336e-06 1.64595649749024 0.391608391608392 25.3 25 3 postnatal lethality 1.96395874044639e-09 1.6017532350362e-07 1.64577943676547 0.391566265060241 25.3 25 3 decreased spleen weight 9.85883425906128e-05 0.00218962948387633 1.64467858095492 0.391304347826087 25.3 25 3 abnormal allantois morphology 0.00137138199222193 0.01740465666149 1.64467858095492 0.391304347826087 25.3 25 3 abnormal postnatal growth 0.0213890474789532 0.133097344868253 1.64467858095492 0.391304347826087 25.3 25 3 conjunctivitis 0.0213890474789532 0.133097344868253 1.64467858095492 0.391304347826087 25.3 25 3 abnormal palatal shelf fusion at midline 0.0213890474789532 0.133097344868253 1.64467858095492 0.391304347826087 25.3 25 3 abnormal basicranium morphology 0.0213890474789532 0.133097344868253 1.64467858095492 0.391304347826087 25.3 25 3 abnormal vertebral artery topology 0.0213890474789532 0.133097344868253 1.64467858095492 0.391304347826087 25.3 25 3 abnormal skeleton morphology 5.74079150269299e-07 2.6809898970367e-05 1.64467858095492 0.391304347826087 25.3 25 3 preweaning lethality, complete penetrance 9.13304848601764e-37 9.08738324358755e-34 1.64146824738849 0.390540540540541 25.3 25 3 spleen hypoplasia 1.9057207799422e-06 7.58476870416996e-05 1.64119777972539 0.39047619047619 25.3 25 3 lethality at weaning, incomplete penetrance 0.00257194250755341 0.0276358833155037 1.6402214574293 0.390243902439024 25.3 25 3 enlarged spleen 6.25167534006985e-15 1.41373112803852e-12 1.63452624403545 0.388888888888889 25.3 25 3 abnormal neuromuscular synapse morphology 8.39631707889416e-05 0.00195194754521021 1.63452624403545 0.388888888888889 25.3 25 3 abnormal systemic arterial blood pressure 0.00485404429577381 0.046440135329759 1.63452624403545 0.388888888888889 25.3 25 3 lowered ear position 0.0422647314091333 0.201020113537704 1.63452624403545 0.388888888888889 25.3 25 3 abnormal heart shape 0.0422647314091333 0.201020113537704 1.63452624403545 0.388888888888889 25.3 25 3 cortical renal glomerulopathies 0.0422647314091333 0.201020113537704 1.63452624403545 0.388888888888889 25.3 25 3 delayed kidney development 0.0422647314091333 0.201020113537704 1.63452624403545 0.388888888888889 25.3 25 3 abnormal phrenic nerve morphology 0.0422647314091333 0.201020113537704 1.63452624403545 0.388888888888889 25.3 25 3 blepharoptosis 0.0422647314091333 0.201020113537704 1.63452624403545 0.388888888888889 25.3 25 3 abnormal thyroid cartilage morphology 0.0422647314091333 0.201020113537704 1.63452624403545 0.388888888888889 25.3 25 3 abnormal thymus medulla morphology 0.0422647314091333 0.201020113537704 1.63452624403545 0.388888888888889 25.3 25 3 absent inner cell mass 0.0422647314091333 0.201020113537704 1.63452624403545 0.388888888888889 25.3 25 3 darkened coat color 0.0422647314091333 0.201020113537704 1.63452624403545 0.388888888888889 25.3 25 3 primary atelectasis 0.0422647314091333 0.201020113537704 1.63452624403545 0.388888888888889 25.3 25 3 abnormal hypoglossal nerve topology 0.0422647314091333 0.201020113537704 1.63452624403545 0.388888888888889 25.3 25 3 increased adipocyte glucose uptake 0.0422647314091333 0.201020113537704 1.63452624403545 0.388888888888889 25.3 25 3 abnormal bone structure 1.78333403158409e-10 2.11240162074544e-08 1.63331638005022 0.38860103626943 25.3 25 3 abnormal femur morphology 0.000154615647859179 0.00319175455642911 1.63104111345115 0.388059701492537 25.3 25 3 internal hemorrhage 0.000154615647859179 0.00319175455642911 1.63104111345115 0.388059701492537 25.3 25 3 abnormal hepatocyte morphology 1.39097066629079e-06 5.67219595475138e-05 1.62821533189631 0.387387387387387 25.3 25 3 decreased double-negative T cell number 0.00923602515184466 0.0737535460597705 1.62699386503067 0.387096774193548 25.3 25 3 embryonic lethality during organogenesis, incomplete penetrance 4.94175692188164e-12 7.68288771448787e-10 1.62640437449987 0.38695652173913 25.3 25 3 abnormal circadian rhythm 0.00216965422383395 0.0243623884416826 1.623912437256 0.386363636363636 25.3 25 3 omphalocele 0.00216965422383395 0.0243623884416826 1.623912437256 0.386363636363636 25.3 25 3 cochlear hair cell degeneration 0.00216965422383395 0.0243623884416826 1.623912437256 0.386363636363636 25.3 25 3 decreased sensitivity to induced morbidity/mortality 0.00216965422383395 0.0243623884416826 1.623912437256 0.386363636363636 25.3 25 3 lethality, incomplete penetrance 0.00216965422383395 0.0243623884416826 1.623912437256 0.386363636363636 25.3 25 3 abnormal liver morphology 1.3995575184988e-09 1.26482992750352e-07 1.62017685162971 0.385474860335196 25.3 25 3 increased bone mineral content 2.1601110992778e-06 8.46185253457248e-05 1.61953059042044 0.385321100917431 25.3 25 3 impaired macrophage chemotaxis 0.00407863423807514 0.0402603280444917 1.61656441717791 0.384615384615385 25.3 25 3 abnormal Schwann cell morphology 0.0177666289427408 0.116148461222254 1.61656441717791 0.384615384615385 25.3 25 3 pulmonary edema 0.0177666289427408 0.116148461222254 1.61656441717791 0.384615384615385 25.3 25 3 decreased Peyer's patch number 0.0177666289427408 0.116148461222254 1.61656441717791 0.384615384615385 25.3 25 3 short premaxilla 0.0861350311150254 0.331523227590914 1.61656441717791 0.384615384615385 25.3 25 3 absent myocardial trabeculae 0.0861350311150254 0.331523227590914 1.61656441717791 0.384615384615385 25.3 25 3 abnormal mast cell morphology 0.0861350311150254 0.331523227590914 1.61656441717791 0.384615384615385 25.3 25 3 excessive scratching 0.0861350311150254 0.331523227590914 1.61656441717791 0.384615384615385 25.3 25 3 dystrophic cardiac calcinosis 0.0861350311150254 0.331523227590914 1.61656441717791 0.384615384615385 25.3 25 3 abnormal bile duct development 0.0861350311150254 0.331523227590914 1.61656441717791 0.384615384615385 25.3 25 3 anal atresia 0.0861350311150254 0.331523227590914 1.61656441717791 0.384615384615385 25.3 25 3 axonal dystrophy 0.0861350311150254 0.331523227590914 1.61656441717791 0.384615384615385 25.3 25 3 abnormal exocrine pancreas morphology 0.0861350311150254 0.331523227590914 1.61656441717791 0.384615384615385 25.3 25 3 abnormal vertebral arch development 0.0861350311150254 0.331523227590914 1.61656441717791 0.384615384615385 25.3 25 3 decreased cardiac stroke volume 0.0861350311150254 0.331523227590914 1.61656441717791 0.384615384615385 25.3 25 3 thymus hypoplasia 1.22826627838359e-07 6.57056423113802e-06 1.6142215701965 0.384057971014493 25.3 25 3 liver inflammation 8.61950136331877e-07 3.82875172165276e-05 1.61117586912065 0.383333333333333 25.3 25 3 intracranial hemorrhage 0.000446879786731808 0.00756199639112498 1.61117586912065 0.383333333333333 25.3 25 3 abnormal tibia morphology 0.00182783990504553 0.0218593834798114 1.60968541965801 0.382978723404255 25.3 25 3 increased cellular sensitivity to gamma-irradiation 0.00182783990504553 0.0218593834798114 1.60968541965801 0.382978723404255 25.3 25 3 increased circulating aspartate transaminase level 0.000377725308665115 0.0066830151998699 1.60116856558574 0.380952380952381 25.3 25 3 abnormal cartilage morphology 0.00342310763497461 0.0345435303935064 1.60116856558574 0.380952380952381 25.3 25 3 left pulmonary isomerism 0.0347048007214636 0.180853387173316 1.60116856558574 0.380952380952381 25.3 25 3 vascular ring 0.0347048007214636 0.180853387173316 1.60116856558574 0.380952380952381 25.3 25 3 embryonic lethality at implantation, complete penetrance 0.0347048007214636 0.180853387173316 1.60116856558574 0.380952380952381 25.3 25 3 abnormal skeletal muscle fiber morphology 0.000173401125764322 0.00353553524867829 1.59834960684352 0.380281690140845 25.3 25 3 decreased circulating alkaline phosphatase level 0.00153828243144453 0.0190372017324292 1.59716564417178 0.38 25.3 25 3 abnormal axon morphology 4.4015183853621e-06 0.000151017613566734 1.59560895251079 0.37962962962963 25.3 25 3 absent long term depression 0.0147480191556334 0.103032341027774 1.59426697694098 0.379310344827586 25.3 25 3 kidney cysts 0.000146615055014797 0.00305192426233731 1.59034985906152 0.378378378378378 25.3 25 3 malocclusion 0.00644860000464279 0.0568825975586842 1.59034985906152 0.378378378378378 25.3 25 3 abnormal mesoderm development 0.00129355321524762 0.0170249398038543 1.58606320175946 0.377358490566038 25.3 25 3 increased osteoclast cell number 0.000588135622833863 0.00937812411409766 1.58476314995474 0.377049180327869 25.3 25 3 increased double-negative T cell number 0.000588135622833863 0.00937812411409766 1.58476314995474 0.377049180327869 25.3 25 3 abnormal heart morphology 4.55968721039325e-11 5.67111096792661e-09 1.58297346824954 0.376623376623377 25.3 25 3 abnormal pulmonary alveolus morphology 1.23430915734972e-05 0.000379054818383634 1.58135212294236 0.376237623762376 25.3 25 3 abnormal retinal pigment epithelium morphology 0.000104616139319776 0.00231317908051504 1.57615030674847 0.375 25.3 25 3 kidney cortex cysts 0.0122400750279021 0.0907516740146244 1.57615030674847 0.375 25.3 25 3 bradykinesia 0.0122400750279021 0.0907516740146244 1.57615030674847 0.375 25.3 25 3 disorganized retinal layers 0.0693809216350633 0.284559014950074 1.57615030674847 0.375 25.3 25 3 poor circulation 0.0693809216350633 0.284559014950074 1.57615030674847 0.375 25.3 25 3 abnormal olfaction 0.0693809216350633 0.284559014950074 1.57615030674847 0.375 25.3 25 3 increased intestinal adenocarcinoma incidence 0.0693809216350633 0.284559014950074 1.57615030674847 0.375 25.3 25 3 impaired muscle relaxation 0.0693809216350633 0.284559014950074 1.57615030674847 0.375 25.3 25 3 abnormal level of surface class II molecules 0.0693809216350633 0.284559014950074 1.57615030674847 0.375 25.3 25 3 sepsis 0.0693809216350633 0.284559014950074 1.57615030674847 0.375 25.3 25 3 decreased creatinine clearance 0.0693809216350633 0.284559014950074 1.57615030674847 0.375 25.3 25 3 impaired behavioral response to addictive substance 0.0693809216350633 0.284559014950074 1.57615030674847 0.375 25.3 25 3 decreased fibroblast apoptosis 0.0693809216350633 0.284559014950074 1.57615030674847 0.375 25.3 25 3 hemolytic anemia 0.0285210844747651 0.156909673722941 1.57615030674847 0.375 25.3 25 3 increased hemangiosarcoma incidence 0.0285210844747651 0.156909673722941 1.57615030674847 0.375 25.3 25 3 abnormal lung saccule morphology 0.0285210844747651 0.156909673722941 1.57615030674847 0.375 25.3 25 3 decreased total body fat amount 5.21798191794656e-15 1.23616476389448e-12 1.57300429815216 0.374251497005988 25.3 25 3 delayed bone ossification 0.00019141280408392 0.00385537935351216 1.56914519427403 0.373333333333333 25.3 25 3 rib fusion 0.000416851739629645 0.00712658901944152 1.5683087629338 0.373134328358209 25.3 25 3 abnormal thoracic vertebrae morphology 0.000913106651620679 0.013400311480274 1.56724550275554 0.372881355932203 25.3 25 3 increased lung adenocarcinoma incidence 0.00201528353713215 0.0230483576947873 1.56584867075665 0.372549019607843 25.3 25 3 abnormal cervical vertebrae morphology 0.00201528353713215 0.0230483576947873 1.56584867075665 0.372549019607843 25.3 25 3 abnormal thrombosis 0.00201528353713215 0.0230483576947873 1.56584867075665 0.372549019607843 25.3 25 3 increased neutrophil cell number 3.03861717630448e-07 1.52698186384998e-05 1.56528030463296 0.372413793103448 25.3 25 3 decreased bone mineral density 4.93501486701768e-12 7.68288771448787e-10 1.56429955256239 0.37218045112782 25.3 25 3 abnormal embryonic epiblast morphology 0.0101595912658294 0.0779999483757734 1.5611393514461 0.371428571428571 25.3 25 3 decreased glycogen level 0.0101595912658294 0.0779999483757734 1.5611393514461 0.371428571428571 25.3 25 3 increased red blood cell distribution width 0.0101595912658294 0.0779999483757734 1.5611393514461 0.371428571428571 25.3 25 3 abnormal muscle physiology 6.28265161663612e-05 0.00155503441755048 1.55844075274006 0.370786516853933 25.3 25 3 short snout 1.14540160710814e-05 0.000355328552996863 1.55669166098614 0.37037037037037 25.3 25 3 abnormal chondrocyte morphology 0.00168771739770459 0.0205290808155998 1.55669166098614 0.37037037037037 25.3 25 3 abnormal mandible morphology 0.00168771739770459 0.0205290808155998 1.55669166098614 0.37037037037037 25.3 25 3 neurodegeneration 0.00168771739770459 0.0205290808155998 1.55669166098614 0.37037037037037 25.3 25 3 decreased tumor growth/size 0.00168771739770459 0.0205290808155998 1.55669166098614 0.37037037037037 25.3 25 3 abnormal trigeminal nerve morphology 0.0234649944461429 0.142879491662361 1.55669166098614 0.37037037037037 25.3 25 3 increased brain weight 0.0234649944461429 0.142879491662361 1.55669166098614 0.37037037037037 25.3 25 3 abnormal palate morphology 0.0234649944461429 0.142879491662361 1.55669166098614 0.37037037037037 25.3 25 3 thick interventricular septum 0.0234649944461429 0.142879491662361 1.55669166098614 0.37037037037037 25.3 25 3 abnormal cell death 0.0037493431133411 0.0374557871262489 1.55330754867965 0.369565217391304 25.3 25 3 abnormal craniofacial morphology 2.07533306936321e-05 0.000589987544004684 1.55064625647746 0.368932038834951 25.3 25 3 incomplete embryo turning 0.00141310779967828 0.0177530588469683 1.54849854698095 0.368421052631579 25.3 25 3 impaired branching involved in ureteric bud morphogenesis 0.00843490695247422 0.069132886472091 1.54849854698095 0.368421052631579 25.3 25 3 abnormal stationary movement 0.0561413089327682 0.239745074627057 1.54849854698095 0.368421052631579 25.3 25 3 decreased tumor incidence 0.0561413089327682 0.239745074627057 1.54849854698095 0.368421052631579 25.3 25 3 osteoarthritis 0.0561413089327682 0.239745074627057 1.54849854698095 0.368421052631579 25.3 25 3 oliguria 0.0561413089327682 0.239745074627057 1.54849854698095 0.368421052631579 25.3 25 3 decreased eye pigmentation 0.0561413089327682 0.239745074627057 1.54849854698095 0.368421052631579 25.3 25 3 decreased fertilization frequency 0.0561413089327682 0.239745074627057 1.54849854698095 0.368421052631579 25.3 25 3 decreased circulating magnesium level 0.0561413089327682 0.239745074627057 1.54849854698095 0.368421052631579 25.3 25 3 organ of Corti degeneration 0.00312872824667061 0.032159964932203 1.54398397395768 0.36734693877551 25.3 25 3 increased sarcoma incidence 0.00312872824667061 0.032159964932203 1.54398397395768 0.36734693877551 25.3 25 3 kyphosis 4.26759552020887e-07 2.04146997240761e-05 1.54112474437628 0.366666666666667 25.3 25 3 abnormal incisor morphology 0.00118302746813529 0.0157714023948869 1.54112474437628 0.366666666666667 25.3 25 3 muscular ventricular septal defect 0.00118302746813529 0.0157714023948869 1.54112474437628 0.366666666666667 25.3 25 3 gastrointestinal hemorrhage 0.0193278843095583 0.123435461412134 1.54112474437628 0.366666666666667 25.3 25 3 delayed eyelid opening 0.0193278843095583 0.123435461412134 1.54112474437628 0.366666666666667 25.3 25 3 emphysema 0.0193278843095583 0.123435461412134 1.54112474437628 0.366666666666667 25.3 25 3 abnormal optic cup morphology 0.0193278843095583 0.123435461412134 1.54112474437628 0.366666666666667 25.3 25 3 abnormal cellular respiration 0.0193278843095583 0.123435461412134 1.54112474437628 0.366666666666667 25.3 25 3 cleft palate 2.29550531275214e-06 8.85282087669916e-05 1.54005526155575 0.366412213740458 25.3 25 3 corneal opacity 0.00045314332685285 0.00759439854648091 1.53915147325672 0.366197183098592 25.3 25 3 abnormal mammary gland development 0.00700545949639465 0.0591396745355022 1.53770761633997 0.365853658536585 25.3 25 3 liver fibrosis 0.00700545949639465 0.0591396745355022 1.53770761633997 0.365853658536585 25.3 25 3 decreased cardiac muscle contractility 2.66859645801842e-05 0.000725479091729052 1.53573619631902 0.365384615384615 25.3 25 3 abnormal snout morphology 0.00261098475935256 0.0278307105055583 1.53573619631902 0.365384615384615 25.3 25 3 decreased leukocyte cell number 1.63442639662047e-06 6.55747687353776e-05 1.53396623527831 0.364963503649635 25.3 25 3 decreased T cell proliferation 6.47529710948077e-07 2.98283362219137e-05 1.53355164980932 0.364864864864865 25.3 25 3 abnormal intestine morphology 0.00038015945760064 0.0066830151998699 1.53355164980932 0.364864864864865 25.3 25 3 respiratory distress 8.62525237434205e-08 4.82141916430918e-06 1.53059682967481 0.364161849710983 25.3 25 3 insulin resistance 2.938855706644e-06 0.000109930880756044 1.52838817624094 0.363636363636364 25.3 25 3 small kidney 0.000123671897010521 0.00265201589494544 1.52838817624094 0.363636363636364 25.3 25 3 increased circulating calcium level 0.00217914831287412 0.0243623884416826 1.52838817624094 0.363636363636364 25.3 25 3 abnormal embryo turning 0.00217914831287412 0.0243623884416826 1.52838817624094 0.363636363636364 25.3 25 3 abnormal myelopoiesis 0.00582059495996733 0.051895089472827 1.52838817624094 0.363636363636364 25.3 25 3 renal interstitial fibrosis 0.00582059495996733 0.051895089472827 1.52838817624094 0.363636363636364 25.3 25 3 belly spot 0.0159386762679624 0.10785586805216 1.52838817624094 0.363636363636364 25.3 25 3 abnormal locomotor coordination 0.0159386762679624 0.10785586805216 1.52838817624094 0.363636363636364 25.3 25 3 abnormal middle ear ossicle morphology 0.0159386762679624 0.10785586805216 1.52838817624094 0.363636363636364 25.3 25 3 decreased sensitivity to xenobiotic induced morbidity/mortality 0.0159386762679624 0.10785586805216 1.52838817624094 0.363636363636364 25.3 25 3 abnormal tail movements 0.0456035263869575 0.212432157092803 1.52838817624094 0.363636363636364 25.3 25 3 abnormal tracheal cartilage morphology 0.0456035263869575 0.212432157092803 1.52838817624094 0.363636363636364 25.3 25 3 prolonged PR interval 0.0456035263869575 0.212432157092803 1.52838817624094 0.363636363636364 25.3 25 3 abnormal basement membrane morphology 0.0456035263869575 0.212432157092803 1.52838817624094 0.363636363636364 25.3 25 3 increased circulating creatine kinase level 0.0456035263869575 0.212432157092803 1.52838817624094 0.363636363636364 25.3 25 3 abnormal behavior 1.57897954945498e-11 2.12308736717257e-09 1.52701372644216 0.363309352517986 25.3 25 3 increased tumor incidence 6.27201044139944e-06 0.000206644052622266 1.52530674846626 0.362903225806452 25.3 25 3 abnormal embryo size 1.59261261107901e-05 0.000483124862202322 1.52500678647049 0.36283185840708 25.3 25 3 microcephaly 0.000693958645606459 0.0105579335226059 1.52285053792122 0.36231884057971 25.3 25 3 increased lymphocyte cell number 0.000693958645606459 0.0105579335226059 1.52285053792122 0.36231884057971 25.3 25 3 cochlear ganglion degeneration 0.00181899048028835 0.0218593834798114 1.52180029617093 0.362068965517241 25.3 25 3 glomerulosclerosis 0.00181899048028835 0.0218593834798114 1.52180029617093 0.362068965517241 25.3 25 3 abnormal forebrain development 0.000580927351432976 0.00932294701090017 1.51777436946149 0.361111111111111 25.3 25 3 postnatal lethality, incomplete penetrance 1.67383592709564e-21 8.32733373730081e-19 1.51695217316167 0.360915492957746 25.3 25 3 decreased circulating cholesterol level 6.59991933470906e-08 3.81797659188111e-06 1.51586040430454 0.360655737704918 25.3 25 3 decreased double-positive T cell number 6.15628750017609e-05 0.0015313765156688 1.51310429447853 0.36 25.3 25 3 diaphragmatic hernia 0.0371644190446008 0.181623757118752 1.51310429447853 0.36 25.3 25 3 increased liver glycogen level 0.0371644190446008 0.181623757118752 1.51310429447853 0.36 25.3 25 3 decreased body weight 4.62754285572675e-45 2.30220257072406e-41 1.51079566290375 0.359450726978998 25.3 25 3 abnormal response to injury 0.0108744196725378 0.083359380386557 1.50879345603272 0.358974358974359 25.3 25 3 abnormal pancreatic islet morphology 0.00334719650458766 0.0338461435169179 1.50676004167149 0.358490566037736 25.3 25 3 decreased white adipose tissue amount 0.00105904514156424 0.01471717759576 1.50557641241645 0.358208955223881 25.3 25 3 decreased heart weight 0.000340904978592742 0.00613775394161735 1.50480193895327 0.358024691358025 25.3 25 3 increased inflammatory response 0.000111028536531073 0.00241208283511828 1.50425573135292 0.357894736842105 25.3 25 3 reduced female fertility 2.26008673887815e-09 1.81353734289013e-07 1.50368362597842 0.357758620689655 25.3 25 3 abnormal retina morphology 1.41771584103036e-08 9.79602265156392e-07 1.50109553023663 0.357142857142857 25.3 25 3 abnormal coat/hair pigmentation 3.06220999016107e-05 0.000810345462821878 1.50109553023663 0.357142857142857 25.3 25 3 abnormal ovulation 0.0303709655958761 0.163700491700416 1.50109553023663 0.357142857142857 25.3 25 3 abnormal vasoconstriction 0.113594946261169 0.381075426601022 1.50109553023663 0.357142857142857 25.3 25 3 abnormal kidney blood vessel morphology 0.113594946261169 0.381075426601022 1.50109553023663 0.357142857142857 25.3 25 3 translucent skin 0.113594946261169 0.381075426601022 1.50109553023663 0.357142857142857 25.3 25 3 increased lactate dehydrogenase level 0.113594946261169 0.381075426601022 1.50109553023663 0.357142857142857 25.3 25 3 amyloid beta deposits 0.113594946261169 0.381075426601022 1.50109553023663 0.357142857142857 25.3 25 3 absent olfactory bulb 0.113594946261169 0.381075426601022 1.50109553023663 0.357142857142857 25.3 25 3 abnormal voluntary movement 0.113594946261169 0.381075426601022 1.50109553023663 0.357142857142857 25.3 25 3 abnormal imprinting 0.113594946261169 0.381075426601022 1.50109553023663 0.357142857142857 25.3 25 3 enlarged stomach 0.113594946261169 0.381075426601022 1.50109553023663 0.357142857142857 25.3 25 3 abnormal pancreas development 0.113594946261169 0.381075426601022 1.50109553023663 0.357142857142857 25.3 25 3 abnormal maternal decidual layer morphology 0.113594946261169 0.381075426601022 1.50109553023663 0.357142857142857 25.3 25 3 split sternum 0.113594946261169 0.381075426601022 1.50109553023663 0.357142857142857 25.3 25 3 increased stomach tumor incidence 0.113594946261169 0.381075426601022 1.50109553023663 0.357142857142857 25.3 25 3 abnormal renal tubule epithelial cell primary cilium morphology 0.113594946261169 0.381075426601022 1.50109553023663 0.357142857142857 25.3 25 3 multiple persisting craniopharyngeal ducts 0.113594946261169 0.381075426601022 1.50109553023663 0.357142857142857 25.3 25 3 decreased response to antigen 0.113594946261169 0.381075426601022 1.50109553023663 0.357142857142857 25.3 25 3 domed cranium 0.000884656492709809 0.0130590945401827 1.50109553023663 0.357142857142857 25.3 25 3 abnormal reproductive system morphology 0.00899565497496135 0.0719507773318854 1.50109553023663 0.357142857142857 25.3 25 3 abnormal cytotoxic T cell physiology 0.00899565497496135 0.0719507773318854 1.50109553023663 0.357142857142857 25.3 25 3 increased B cell proliferation 0.00231961049086786 0.0255877210467131 1.4960070708121 0.355932203389831 25.3 25 3 abnormal axial skeleton morphology 0.000617662407210267 0.00981747755869353 1.49319502744592 0.355263157894737 25.3 25 3 abnormal definitive hematopoiesis 0.000167677554413534 0.00344709021986501 1.49141104294479 0.354838709677419 25.3 25 3 osteopetrosis 0.0248784068463009 0.144020875247524 1.49141104294479 0.354838709677419 25.3 25 3 abnormal cranial ganglia morphology 0.0248784068463009 0.144020875247524 1.49141104294479 0.354838709677419 25.3 25 3 abnormal object recognition memory 0.0248784068463009 0.144020875247524 1.49141104294479 0.354838709677419 25.3 25 3 decreased thymus weight 0.0248784068463009 0.144020875247524 1.49141104294479 0.354838709677419 25.3 25 3 decreased neuronal precursor cell number 0.0248784068463009 0.144020875247524 1.49141104294479 0.354838709677419 25.3 25 3 preaxial polydactyly 0.0248784068463009 0.144020875247524 1.49141104294479 0.354838709677419 25.3 25 3 abnormal mitochondrial ATP synthesis coupled electron transport 0.0248784068463009 0.144020875247524 1.49141104294479 0.354838709677419 25.3 25 3 hunched posture 0.000516257561414477 0.00850457406634775 1.48969480469053 0.354430379746835 25.3 25 3 weight loss 3.35066785381764e-07 1.65045272997453e-05 1.48908676599474 0.354285714285714 25.3 25 3 oligodactyly 0.00617214097559672 0.0545406773598467 1.488586400818 0.354166666666667 25.3 25 3 abnormal kidney physiology 0.00617214097559672 0.0545406773598467 1.488586400818 0.354166666666667 25.3 25 3 thymus atrophy 0.00617214097559672 0.0545406773598467 1.488586400818 0.354166666666667 25.3 25 3 abnormal brain morphology 1.00140613307026e-06 4.26618112128613e-05 1.48804252562588 0.354037267080745 25.3 25 3 abnormal neuron morphology 0.000117662696902603 0.00253407756316211 1.48593294912313 0.353535353535354 25.3 25 3 abnormal retinal photoreceptor morphology 0.0204212290588172 0.129751742742804 1.48343558282209 0.352941176470588 25.3 25 3 thin skin 0.0204212290588172 0.129751742742804 1.48343558282209 0.352941176470588 25.3 25 3 abnormal bone remodeling 0.0204212290588172 0.129751742742804 1.48343558282209 0.352941176470588 25.3 25 3 increased width of hypertrophic chondrocyte zone 0.0204212290588172 0.129751742742804 1.48343558282209 0.352941176470588 25.3 25 3 abnormal vagus nerve morphology 0.0904173501294658 0.3351909961953 1.48343558282209 0.352941176470588 25.3 25 3 decreased vasoconstriction 0.0904173501294658 0.3351909961953 1.48343558282209 0.352941176470588 25.3 25 3 increased regulatory T cell number 0.0904173501294658 0.3351909961953 1.48343558282209 0.352941176470588 25.3 25 3 abnormal survival 0.0904173501294658 0.3351909961953 1.48343558282209 0.352941176470588 25.3 25 3 increased trabecular bone mass 0.0904173501294658 0.3351909961953 1.48343558282209 0.352941176470588 25.3 25 3 abnormal ductus venosus valve morphology 0.0904173501294658 0.3351909961953 1.48343558282209 0.352941176470588 25.3 25 3 atelectasis 0.00111917451763208 0.015221520611753 1.47995333966992 0.352112676056338 25.3 25 3 improved glucose tolerance 9.98628184578504e-08 5.40019045465006e-06 1.47965130837611 0.352040816326531 25.3 25 3 abnormal osteoblast physiology 0.00424805659118131 0.0415207888823714 1.47885707793683 0.351851851851852 25.3 25 3 abnormal T cell activation 0.000933570952767996 0.0135804546491836 1.47675344055712 0.351351351351351 25.3 25 3 impaired skeletal muscle contractility 0.0167928421348358 0.110654820689812 1.47675344055712 0.351351351351351 25.3 25 3 abnormal calcium ion homeostasis 0.0167928421348358 0.110654820689812 1.47675344055712 0.351351351351351 25.3 25 3 skin inflammation 0.0167928421348358 0.110654820689812 1.47675344055712 0.351351351351351 25.3 25 3 increased trabecular bone volume 0.0167928421348358 0.110654820689812 1.47675344055712 0.351351351351351 25.3 25 3 abnormal cranium morphology 1.13212142085641e-05 0.000354232960299412 1.47421023715777 0.350746268656716 25.3 25 3 abnormal basioccipital bone morphology 0.0725265414694282 0.293776932989814 1.4710736196319 0.35 25.3 25 3 abnormal vascular regression 0.0725265414694282 0.293776932989814 1.4710736196319 0.35 25.3 25 3 abnormal circulating enzyme level 0.0725265414694282 0.293776932989814 1.4710736196319 0.35 25.3 25 3 anencephaly 0.0725265414694282 0.293776932989814 1.4710736196319 0.35 25.3 25 3 abnormal response to tactile stimuli 0.0725265414694282 0.293776932989814 1.4710736196319 0.35 25.3 25 3 abnormal heart electrocardiography waveform feature 0.0725265414694282 0.293776932989814 1.4710736196319 0.35 25.3 25 3 decreased muscle cell glucose uptake 0.0725265414694282 0.293776932989814 1.4710736196319 0.35 25.3 25 3 premature death 2.6734861658993e-28 2.21676561255817e-25 1.46936505561375 0.349593495934959 25.3 25 3 decreased susceptibility to hepatic steatosis 0.00243753655511701 0.0266517478175706 1.46773785178693 0.349206349206349 25.3 25 3 increased oxygen consumption 0.00045337414438288 0.00759439854648091 1.46618633185904 0.348837209302326 25.3 25 3 abnormal organ of Corti morphology 0.0114078022043186 0.0857798929018631 1.46618633185904 0.348837209302326 25.3 25 3 abnormal homeostasis 0.0114078022043186 0.0857798929018631 1.46618633185904 0.348837209302326 25.3 25 3 kidney failure 0.0114078022043186 0.0857798929018631 1.46618633185904 0.348837209302326 25.3 25 3 abnormal vascular development 0.00202781669419353 0.023085556186757 1.46470533556423 0.348484848484849 25.3 25 3 abnormal skin morphology 0.00202781669419353 0.023085556186757 1.46470533556423 0.348484848484849 25.3 25 3 abnormal rib morphology 1.41557056812632e-05 0.000432052980148984 1.46329016132697 0.348148148148148 25.3 25 3 abnormal locomotor behavior 0.000316455653257971 0.00580368649468455 1.46193651640437 0.347826086956522 25.3 25 3 embryonic lethality between implantation and placentation, complete penetrance 0.0094209485701925 0.0741199601057183 1.46193651640437 0.347826086956522 25.3 25 3 abnormal B cell morphology 0.0585179151378932 0.248826177616255 1.46193651640437 0.347826086956522 25.3 25 3 abnormal heart left ventricle morphology 0.00140547620178052 0.0177018838072357 1.45939843217451 0.347222222222222 25.3 25 3 abnormal limb morphology 0.00117088277045511 0.0157011907897956 1.45706339468303 0.346666666666667 25.3 25 3 abnormal cornea morphology 0.000975847678921462 0.0138654557666293 1.45490797546012 0.346153846153846 25.3 25 3 increased urine protein level 0.000975847678921462 0.0138654557666293 1.45490797546012 0.346153846153846 25.3 25 3 abnormal heart ventricle morphology 0.000975847678921462 0.0138654557666293 1.45490797546012 0.346153846153846 25.3 25 3 abnormal erythrocyte osmotic lysis 0.0474338373338209 0.219928556137706 1.45490797546012 0.346153846153846 25.3 25 3 abnormal Mullerian duct morphology 0.0474338373338209 0.219928556137706 1.45490797546012 0.346153846153846 25.3 25 3 decreased bone resorption 0.0474338373338209 0.219928556137706 1.45490797546012 0.346153846153846 25.3 25 3 increased T cell proliferation 0.000129319046884963 0.00274130443019887 1.4533971675936 0.345794392523364 25.3 25 3 increased sensitivity to xenobiotic induced morbidity/mortality 0.000108190687864295 0.00238163129258792 1.45196876742889 0.345454545454545 25.3 25 3 decreased inflammatory response 0.00067859762577365 0.0103922329210134 1.45105901256208 0.345238095238095 25.3 25 3 increased bone mineral density 9.05302955354937e-05 0.00203795574791439 1.45061621152071 0.345132743362832 25.3 25 3 abnormal embryonic erythropoiesis 0.0385935689854775 0.187869868593689 1.44933361540089 0.344827586206897 25.3 25 3 postnatal growth retardation 2.12500028341926e-19 8.80989700834234e-17 1.44909679618269 0.344771241830065 25.3 25 3 decreased circulating HDL cholesterol level 3.72261191726208e-05 0.000954638880844269 1.44480444785276 0.34375 25.3 25 3 scoliosis 0.0314984854178429 0.16831897417161 1.44480444785276 0.34375 25.3 25 3 abnormal lumbar vertebrae morphology 0.0314984854178429 0.16831897417161 1.44480444785276 0.34375 25.3 25 3 abnormal midbrain development 0.0257751270377674 0.147145947519711 1.44105170902717 0.342857142857143 25.3 25 3 decreased triglyceride level 0.0257751270377674 0.147145947519711 1.44105170902717 0.342857142857143 25.3 25 3 impaired glucose tolerance 1.48017284075527e-08 1.00874792914486e-06 1.44056748466258 0.342741935483871 25.3 25 3 decreased hair follicle number 0.0211389684296638 0.133097344868253 1.43789150791088 0.342105263157895 25.3 25 3 abnormal myocardium layer morphology 0.00121448100916548 0.016069263352655 1.43649141880873 0.341772151898734 25.3 25 3 Leydig cell hyperplasia 0.0173703216851858 0.114007058553825 1.43519377525064 0.341463414634146 25.3 25 3 thick ventricular wall 0.0173703216851858 0.114007058553825 1.43519377525064 0.341463414634146 25.3 25 3 palatal shelves fail to meet at midline 0.0173703216851858 0.114007058553825 1.43519377525064 0.341463414634146 25.3 25 3 decreased bone mineral content 2.60164777295492e-07 1.3343502753042e-05 1.4347009202454 0.341346153846154 25.3 25 3 enlarged heart 6.41920107597376e-08 3.75712062976111e-06 1.43121694520838 0.34051724137931 25.3 25 3 cleft secondary palate 0.000489122917061493 0.0080843405726941 1.43083148414045 0.340425531914894 25.3 25 3 increased B cell derived lymphoma incidence 0.00972880851789189 0.0751565564852673 1.42904294478528 0.34 25.3 25 3 testicular atrophy 0.00972880851789189 0.0751565564852673 1.42904294478528 0.34 25.3 25 3 abnormal axon extension 0.00972880851789189 0.0751565564852673 1.42904294478528 0.34 25.3 25 3 decreased respiratory quotient 0.00972880851789189 0.0751565564852673 1.42904294478528 0.34 25.3 25 3 decreased B cell number 3.81874202281902e-07 1.84448947218686e-05 1.4282268151766 0.339805825242718 25.3 25 3 enlarged kidney 0.00804006515931141 0.066444060079027 1.42745688158352 0.339622641509434 25.3 25 3 abnormal seminal vesicle morphology 0.00665155800228788 0.0584655495784138 1.4260407537248 0.339285714285714 25.3 25 3 abnormal spleen morphology 3.24488165681164e-06 0.000119579898093614 1.42517805514421 0.339080459770115 25.3 25 3 decreased susceptibility to injury 0.00314351336614627 0.0322453175187169 1.42162576687117 0.338235294117647 25.3 25 3 increased heart weight 3.33122033489445e-05 0.000863167769067703 1.42118109193627 0.338129496402878 25.3 25 3 abnormal ovary morphology 0.00261119590209599 0.0278307105055583 1.42075520608312 0.338028169014085 25.3 25 3 increased leukocyte cell number 2.33560018970964e-05 0.000649140276190248 1.42034694309287 0.337931034482759 25.3 25 3 increased circulating triglyceride level 2.33560018970964e-05 0.000649140276190248 1.42034694309287 0.337931034482759 25.3 25 3 abnormal enzyme/coenzyme activity 1.1499074780401e-05 0.000355328552996863 1.41886991520456 0.337579617834395 25.3 25 3 infertility 0.000292679102301283 0.00546108084566632 1.41411616306404 0.336448598130841 25.3 25 3 abnormal glucose homeostasis 3.42999053865352e-06 0.000124865072242175 1.40872042068361 0.335164835164835 25.3 25 3 abnormal motor capabilities/coordination/movement 8.53651472927181e-05 0.00195710418332384 1.40102249488753 0.333333333333333 25.3 25 3 abnormal skeleton development 0.00184610402787032 0.0220248622030092 1.40102249488753 0.333333333333333 25.3 25 3 increased circulating alanine transaminase level 0.00221957784452648 0.0247587438935409 1.40102249488753 0.333333333333333 25.3 25 3 decreased brain weight 0.00821339627711411 0.0676517325805343 1.40102249488753 0.333333333333333 25.3 25 3 distended abdomen 0.0120338801823512 0.0898927235843799 1.40102249488753 0.333333333333333 25.3 25 3 increased kidney weight 0.0120338801823512 0.0898927235843799 1.40102249488753 0.333333333333333 25.3 25 3 cochlear inner hair cell degeneration 0.0120338801823512 0.0898927235843799 1.40102249488753 0.333333333333333 25.3 25 3 dextrocardia 0.0392783899927834 0.190232310792087 1.40102249488753 0.333333333333333 25.3 25 3 abnormal ovarian folliculogenesis 0.0392783899927834 0.190232310792087 1.40102249488753 0.333333333333333 25.3 25 3 cardiovascular system phenotype 0.0392783899927834 0.190232310792087 1.40102249488753 0.333333333333333 25.3 25 3 abnormal brain commissure morphology 0.05941825877766 0.250938741442155 1.40102249488753 0.333333333333333 25.3 25 3 abnormal eye muscle morphology 0.05941825877766 0.250938741442155 1.40102249488753 0.333333333333333 25.3 25 3 abnormal skin appearance 0.05941825877766 0.250938741442155 1.40102249488753 0.333333333333333 25.3 25 3 abnormal digit morphology 0.00321405575225373 0.0326992379702706 1.40102249488753 0.333333333333333 25.3 25 3 abnormal cardiovascular system morphology 0.0145932906685101 0.102929948298112 1.40102249488753 0.333333333333333 25.3 25 3 abnormal osteoclast morphology 0.0145932906685101 0.102929948298112 1.40102249488753 0.333333333333333 25.3 25 3 abnormal pancreas morphology 0.021557655040298 0.133097344868253 1.40102249488753 0.333333333333333 25.3 25 3 abnormal spleen white pulp morphology 0.021557655040298 0.133097344868253 1.40102249488753 0.333333333333333 25.3 25 3 spina bifida 0.021557655040298 0.133097344868253 1.40102249488753 0.333333333333333 25.3 25 3 abnormal epidermis stratum granulosum morphology 0.0320835012148077 0.170529293315885 1.40102249488753 0.333333333333333 25.3 25 3 short radius 0.0320835012148077 0.170529293315885 1.40102249488753 0.333333333333333 25.3 25 3 increased metastatic potential 0.048226411323437 0.221108783860481 1.40102249488753 0.333333333333333 25.3 25 3 enhanced paired-pulse facilitation 0.048226411323437 0.221108783860481 1.40102249488753 0.333333333333333 25.3 25 3 abnormal malleus morphology 0.0735163304694572 0.295192690948789 1.40102249488753 0.333333333333333 25.3 25 3 abnormal adrenal gland morphology 0.0735163304694572 0.295192690948789 1.40102249488753 0.333333333333333 25.3 25 3 abnormal body weight 0.0735163304694572 0.295192690948789 1.40102249488753 0.333333333333333 25.3 25 3 decreased metastatic potential 0.0735163304694572 0.295192690948789 1.40102249488753 0.333333333333333 25.3 25 3 abnormal tumor morphology 0.0735163304694572 0.295192690948789 1.40102249488753 0.333333333333333 25.3 25 3 abnormal eye pigmentation 0.0914374118434103 0.338216449011871 1.40102249488753 0.333333333333333 25.3 25 3 trunk curl 0.0914374118434103 0.338216449011871 1.40102249488753 0.333333333333333 25.3 25 3 hypoalgesia 0.0914374118434103 0.338216449011871 1.40102249488753 0.333333333333333 25.3 25 3 abnormal megakaryocyte differentiation 0.114493659489632 0.381517720000617 1.40102249488753 0.333333333333333 25.3 25 3 right pulmonary isomerism 0.114493659489632 0.381517720000617 1.40102249488753 0.333333333333333 25.3 25 3 absent spleen 0.114493659489632 0.381517720000617 1.40102249488753 0.333333333333333 25.3 25 3 abnormal retinal rod cell morphology 0.114493659489632 0.381517720000617 1.40102249488753 0.333333333333333 25.3 25 3 thick dermal layer 0.114493659489632 0.381517720000617 1.40102249488753 0.333333333333333 25.3 25 3 abnormal iron level 0.114493659489632 0.381517720000617 1.40102249488753 0.333333333333333 25.3 25 3 abnormal metacarpal bone morphology 0.114493659489632 0.381517720000617 1.40102249488753 0.333333333333333 25.3 25 3 increased circulating renin level 0.114493659489632 0.381517720000617 1.40102249488753 0.333333333333333 25.3 25 3 small thoracic cage 0.114493659489632 0.381517720000617 1.40102249488753 0.333333333333333 25.3 25 3 increased effector memory CD4-positive, alpha-beta T cell number 0.114493659489632 0.381517720000617 1.40102249488753 0.333333333333333 25.3 25 3 abnormal fontanelle morphology 0.144652750024072 0.452893285946983 1.40102249488753 0.333333333333333 25.3 25 3 abnormal enteric neuron morphology 0.144652750024072 0.452893285946983 1.40102249488753 0.333333333333333 25.3 25 3 abnormal epidermis stratum spinosum morphology 0.144652750024072 0.452893285946983 1.40102249488753 0.333333333333333 25.3 25 3 increased airway responsiveness 0.144652750024072 0.452893285946983 1.40102249488753 0.333333333333333 25.3 25 3 abnormal respiratory system morphology 0.144652750024072 0.452893285946983 1.40102249488753 0.333333333333333 25.3 25 3 abnormal ear development 0.144652750024072 0.452893285946983 1.40102249488753 0.333333333333333 25.3 25 3 abnormal rostral migratory stream morphology 0.144652750024072 0.452893285946983 1.40102249488753 0.333333333333333 25.3 25 3 abnormal zygomatic bone morphology 0.144652750024072 0.452893285946983 1.40102249488753 0.333333333333333 25.3 25 3 immune system phenotype 0.144652750024072 0.452893285946983 1.40102249488753 0.333333333333333 25.3 25 3 abnormal Muller cell morphology 0.144652750024072 0.452893285946983 1.40102249488753 0.333333333333333 25.3 25 3 liver vascular congestion 0.144652750024072 0.452893285946983 1.40102249488753 0.333333333333333 25.3 25 3 ostium primum atrial septal defect 0.144652750024072 0.452893285946983 1.40102249488753 0.333333333333333 25.3 25 3 decreased trabecular bone mass 0.144652750024072 0.452893285946983 1.40102249488753 0.333333333333333 25.3 25 3 herniated liver 0.144652750024072 0.452893285946983 1.40102249488753 0.333333333333333 25.3 25 3 abnormal lipid homeostasis 0.000124433587039068 0.00265689740566251 1.39024539877301 0.330769230769231 25.3 25 3 abnormal testis morphology 0.000305154850345199 0.00564366312441399 1.38883969058416 0.330434782608696 25.3 25 3 abnormal neuron differentiation 0.000365391618166683 0.00651549570028405 1.38851336546889 0.330357142857143 25.3 25 3 enlarged liver 0.000753367451847769 0.0112891658823574 1.38701226993865 0.33 25.3 25 3 sparse hair 0.00225571864826646 0.0251055934566569 1.38393685470597 0.329268292682927 25.3 25 3 abnormal tooth morphology 0.00688877326591983 0.0591396745355022 1.37913151840491 0.328125 25.3 25 3 decreased eosinophil cell number 0.00688877326591983 0.0591396745355022 1.37913151840491 0.328125 25.3 25 3 cyanosis 5.27434391645033e-06 0.000174932406562269 1.37913151840491 0.328125 25.3 25 3 abnormal lung morphology 0.000309649830493017 0.00570558483963985 1.37747589833479 0.327731092436975 25.3 25 3 dermatitis 0.0100579058140788 0.0775784208140188 1.37686693463084 0.327586206896552 25.3 25 3 decreased litter size 4.76089367686376e-08 2.88846902956063e-06 1.37609326899985 0.327402135231317 25.3 25 3 abnormal contextual conditioning behavior 0.0121720046513655 0.0906522801505142 1.37554935861684 0.327272727272727 25.3 25 3 abnormal joint morphology 0.0121720046513655 0.0906522801505142 1.37554935861684 0.327272727272727 25.3 25 3 abnormal dendritic cell physiology 0.000636944360180564 0.010027842379425 1.37483515853449 0.327102803738318 25.3 25 3 decreased IgA level 0.0147478667829465 0.103032341027774 1.37407975460123 0.326923076923077 25.3 25 3 ataxia 3.75883679059286e-06 0.000134533906713665 1.37327947518678 0.326732673267327 25.3 25 3 absent kidney 0.0178923629985327 0.116663834754522 1.37243019907349 0.326530612244898 25.3 25 3 abnormal myelin sheath morphology 0.0217393758068768 0.133522709431126 1.3705654841291 0.326086956521739 25.3 25 3 increased circulating creatinine level 0.00228002572691418 0.0252839452235782 1.36844057640177 0.325581395348837 25.3 25 3 abnormal left-right axis patterning 0.0264575839955984 0.150258539244409 1.36844057640177 0.325581395348837 25.3 25 3 abnormal double-strand DNA break repair 0.0264575839955984 0.150258539244409 1.36844057640177 0.325581395348837 25.3 25 3 increased susceptibility to weight loss 0.0322609409807118 0.17110680317595 1.36599693251534 0.325 25.3 25 3 respiratory failure 7.57659691813371e-05 0.00182094539457561 1.36390931621501 0.324503311258278 25.3 25 3 increased circulating phosphate level 0.0394230175731943 0.190232310792087 1.36315702205273 0.324324324324324 25.3 25 3 abnormal breathing pattern 0.0394230175731943 0.190232310792087 1.36315702205273 0.324324324324324 25.3 25 3 abnormal pancreatic beta cell physiology 0.0394230175731943 0.190232310792087 1.36315702205273 0.324324324324324 25.3 25 3 abnormal respiratory electron transport chain 0.0394230175731943 0.190232310792087 1.36315702205273 0.324324324324324 25.3 25 3 hypoactivity 7.70512678148557e-10 7.8230623954879e-08 1.36014385445314 0.323607427055703 25.3 25 3 lung hemorrhage 0.0482970321785931 0.221108783860481 1.35981595092025 0.323529411764706 25.3 25 3 abnormal brown adipose tissue morphology 0.0482970321785931 0.221108783860481 1.35981595092025 0.323529411764706 25.3 25 3 increased susceptibility to viral infection induced morbidity/mortality 0.0482970321785931 0.221108783860481 1.35981595092025 0.323529411764706 25.3 25 3 decreased T cell number 5.35599168306967e-05 0.00134576053652887 1.35751247951835 0.322981366459627 25.3 25 3 retinal degeneration 0.00159192828764965 0.0196522164542357 1.35724054192229 0.322916666666667 25.3 25 3 hypoglycemia 0.00191045837032971 0.0222506812971434 1.3558282208589 0.32258064516129 25.3 25 3 lethargy 0.00191045837032971 0.0222506812971434 1.3558282208589 0.32258064516129 25.3 25 3 increased lung adenoma incidence 0.059344508693502 0.250938741442155 1.3558282208589 0.32258064516129 25.3 25 3 abnormal capillary morphology 0.059344508693502 0.250938741442155 1.3558282208589 0.32258064516129 25.3 25 3 decreased insulin secretion 0.002293694861697 0.0253580709709834 1.35432174505794 0.322222222222222 25.3 25 3 abnormal seminiferous tubule morphology 0.000130039767945112 0.00274130443019887 1.35304227245987 0.321917808219178 25.3 25 3 short mandible 0.0147869530640865 0.103032341027774 1.35098597721297 0.321428571428571 25.3 25 3 abnormal eye development 0.0147869530640865 0.103032341027774 1.35098597721297 0.321428571428571 25.3 25 3 enhanced long term potentiation 0.0147869530640865 0.103032341027774 1.35098597721297 0.321428571428571 25.3 25 3 straub tail 0.0731775029163998 0.29502275284367 1.35098597721297 0.321428571428571 25.3 25 3 failure of blastocyst to hatch from the zona pellucida 0.0731775029163998 0.29502275284367 1.35098597721297 0.321428571428571 25.3 25 3 abnormal hormone level 0.0731775029163998 0.29502275284367 1.35098597721297 0.321428571428571 25.3 25 3 decreased circulating progesterone level 0.0731775029163998 0.29502275284367 1.35098597721297 0.321428571428571 25.3 25 3 prolonged QRS complex duration 0.0731775029163998 0.29502275284367 1.35098597721297 0.321428571428571 25.3 25 3 abnormal vertebrae morphology 0.000927712224122486 0.0135363471618462 1.34960882535037 0.321100917431193 25.3 25 3 microphthalmia 0.000109347870847572 0.00239650069368578 1.34608043626449 0.320261437908497 25.3 25 3 decreased body size 3.16849672609904e-18 9.85204450771421e-16 1.34308547442225 0.319548872180451 25.3 25 3 neuron degeneration 0.0264049078550039 0.150258539244409 1.34140451638167 0.319148936170213 25.3 25 3 increased respiratory quotient 0.0264049078550039 0.150258539244409 1.34140451638167 0.319148936170213 25.3 25 3 decreased macrophage cell number 0.0321321792668007 0.170605754378157 1.33733965421082 0.318181818181818 25.3 25 3 abnormal abdominal fat pad morphology 0.112826558389755 0.381075426601022 1.33733965421082 0.318181818181818 25.3 25 3 increased body size 0.112826558389755 0.381075426601022 1.33733965421082 0.318181818181818 25.3 25 3 abnormal retinal outer plexiform layer morphology 0.112826558389755 0.381075426601022 1.33733965421082 0.318181818181818 25.3 25 3 abnormal mesenteric lymph node morphology 0.112826558389755 0.381075426601022 1.33733965421082 0.318181818181818 25.3 25 3 abnormal occipital bone morphology 0.112826558389755 0.381075426601022 1.33733965421082 0.318181818181818 25.3 25 3 abnormal temporal bone morphology 0.112826558389755 0.381075426601022 1.33733965421082 0.318181818181818 25.3 25 3 abnormal sperm midpiece morphology 0.112826558389755 0.381075426601022 1.33733965421082 0.318181818181818 25.3 25 3 pulmonary vascular congestion 0.112826558389755 0.381075426601022 1.33733965421082 0.318181818181818 25.3 25 3 rough coat 0.112826558389755 0.381075426601022 1.33733965421082 0.318181818181818 25.3 25 3 impaired humoral immune response 0.112826558389755 0.381075426601022 1.33733965421082 0.318181818181818 25.3 25 3 no abnormal phenotype detected 6.12310163730694e-38 7.61560766140051e-35 1.3372295397889 0.318155619596542 25.3 25 3 cardiac fibrosis 0.00397840391792865 0.039427409346006 1.33509202453988 0.317647058823529 25.3 25 3 gliosis 0.0121907364061789 0.0906560741715101 1.33430713798812 0.317460317460317 25.3 25 3 abnormal response/metabolism to endogenous compounds 0.00478170175565004 0.0459246452400752 1.3326799341613 0.317073170731707 25.3 25 3 increased tumor growth/size 0.0391744427964918 0.190232310792087 1.3326799341613 0.317073170731707 25.3 25 3 reduced fertility 0.000317307080714412 0.00580368649468455 1.33046740521693 0.316546762589928 25.3 25 3 decreased neutrophil cell number 0.000927817966269255 0.0135363471618462 1.3291751874574 0.316239316239316 25.3 25 3 lung inflammation 0.000379015789867686 0.0066830151998699 1.32891104294479 0.316176470588235 25.3 25 3 incomplete somite formation 0.0478618094855929 0.221108783860481 1.32728446884081 0.315789473684211 25.3 25 3 abnormal reproductive system physiology 0.0478618094855929 0.221108783860481 1.32728446884081 0.315789473684211 25.3 25 3 decreased total retina thickness 0.0478618094855929 0.221108783860481 1.32728446884081 0.315789473684211 25.3 25 3 unresponsive to tactile stimuli 0.1414255135928 0.452179903678779 1.32728446884081 0.315789473684211 25.3 25 3 abnormal long term depression 0.1414255135928 0.452179903678779 1.32728446884081 0.315789473684211 25.3 25 3 delayed sexual maturation 0.1414255135928 0.452179903678779 1.32728446884081 0.315789473684211 25.3 25 3 abnormal nasal septum morphology 0.1414255135928 0.452179903678779 1.32728446884081 0.315789473684211 25.3 25 3 increased susceptibility to ischemic brain injury 0.1414255135928 0.452179903678779 1.32728446884081 0.315789473684211 25.3 25 3 abnormal response to novelty 0.1414255135928 0.452179903678779 1.32728446884081 0.315789473684211 25.3 25 3 increased left ventricle weight 0.1414255135928 0.452179903678779 1.32728446884081 0.315789473684211 25.3 25 3 absent amnion 0.1414255135928 0.452179903678779 1.32728446884081 0.315789473684211 25.3 25 3 increased circulating VLDL cholesterol level 0.1414255135928 0.452179903678779 1.32728446884081 0.315789473684211 25.3 25 3 eyelids fail to open 0.1414255135928 0.452179903678779 1.32728446884081 0.315789473684211 25.3 25 3 decreased liver glycogen level 0.1414255135928 0.452179903678779 1.32728446884081 0.315789473684211 25.3 25 3 embryonic lethality between implantation and somite formation, incomplete penetrance 0.1414255135928 0.452179903678779 1.32728446884081 0.315789473684211 25.3 25 3 abnormal cardiovascular system physiology 0.000452796741112126 0.00759439854648091 1.32728446884081 0.315789473684211 25.3 25 3 increased macrophage cell number 0.0178209023503815 0.116350379518567 1.32728446884081 0.315789473684211 25.3 25 3 decreased circulating glucose level 5.76614912528496e-07 2.6809898970367e-05 1.32569870483981 0.315412186379928 25.3 25 3 neonatal lethality, incomplete penetrance 1.37524456771847e-06 5.65441464826395e-05 1.32558282208589 0.315384615384615 25.3 25 3 decreased IgG level 0.00132877498952617 0.0172601973182577 1.32529154921793 0.315315315315315 25.3 25 3 seminiferous tubule degeneration 0.00833036078921268 0.0683886879972493 1.32425413900328 0.315068493150685 25.3 25 3 astrocytosis 0.00833036078921268 0.0683886879972493 1.32425413900328 0.315068493150685 25.3 25 3 abnormal long bone epiphyseal plate proliferative zone 0.0215816369498487 0.133097344868253 1.32318791183822 0.314814814814815 25.3 25 3 decreased rib number 0.00396064827439476 0.0393297907487304 1.32231336596126 0.314606741573034 25.3 25 3 decreased bone volume 0.058619572034805 0.24904557717605 1.32096406660824 0.314285714285714 25.3 25 3 abnormal gait 2.02327087723185e-07 1.05955501202405e-05 1.31940953402029 0.313915857605178 25.3 25 3 decreased body length 9.66306220491229e-07 4.21699425170514e-05 1.31921096233935 0.313868613138686 25.3 25 3 kinked tail 0.00228190782017821 0.0252839452235782 1.31860940695297 0.313725490196078 25.3 25 3 abnormal motor coordination/ balance 0.00273424633173305 0.029003998934695 1.31611204065192 0.313131313131313 25.3 25 3 abnormal posture 0.00686602493067199 0.0591396745355022 1.31345858895706 0.3125 25.3 25 3 abnormal diaphragm morphology 0.0720017920006198 0.29337339492472 1.31345858895706 0.3125 25.3 25 3 abnormal heart atrium morphology 0.0720017920006198 0.29337339492472 1.31345858895706 0.3125 25.3 25 3 increased fatty acid level 0.0720017920006198 0.29337339492472 1.31345858895706 0.3125 25.3 25 3 pancreatic islet hyperplasia 0.0720017920006198 0.29337339492472 1.31345858895706 0.3125 25.3 25 3 abnormal auditory brainstem response waveform shape 0.0720017920006198 0.29337339492472 1.31345858895706 0.3125 25.3 25 3 abnormal mouth morphology 0.178867217473621 0.465167370189853 1.31345858895706 0.3125 25.3 25 3 white spotting 0.178867217473621 0.465167370189853 1.31345858895706 0.3125 25.3 25 3 paternal imprinting 0.178867217473621 0.465167370189853 1.31345858895706 0.3125 25.3 25 3 abnormal molar crown morphology 0.178867217473621 0.465167370189853 1.31345858895706 0.3125 25.3 25 3 increased thymus weight 0.178867217473621 0.465167370189853 1.31345858895706 0.3125 25.3 25 3 decreased liver cholesterol level 0.178867217473621 0.465167370189853 1.31345858895706 0.3125 25.3 25 3 decreased skeletal muscle weight 0.178867217473621 0.465167370189853 1.31345858895706 0.3125 25.3 25 3 embryonic lethality between somite formation and embryo turning, incomplete penetrance 0.178867217473621 0.465167370189853 1.31345858895706 0.3125 25.3 25 3 decreased midbrain size 0.178867217473621 0.465167370189853 1.31345858895706 0.3125 25.3 25 3 decreased adipocyte glucose uptake 0.178867217473621 0.465167370189853 1.31345858895706 0.3125 25.3 25 3 abnormal lymph node morphology 0.0317738247579557 0.169244944508383 1.31345858895706 0.3125 25.3 25 3 vertebral transformation 0.0317738247579557 0.169244944508383 1.31345858895706 0.3125 25.3 25 3 curly tail 0.0317738247579557 0.169244944508383 1.31345858895706 0.3125 25.3 25 3 abnormal cytokine secretion 0.000262060616042912 0.00501442909543649 1.31004700820652 0.311688311688312 25.3 25 3 altered response to myocardial infarction 0.0386397775472316 0.187910941639762 1.30762099522836 0.311111111111111 25.3 25 3 lordosis 0.0887402731853146 0.333302339578916 1.3044002538608 0.310344827586207 25.3 25 3 abnormal CD8-positive, alpha-beta T cell physiology 0.0887402731853146 0.333302339578916 1.3044002538608 0.310344827586207 25.3 25 3 decreased bone strength 0.0887402731853146 0.333302339578916 1.3044002538608 0.310344827586207 25.3 25 3 polychromatophilia 0.0887402731853146 0.333302339578916 1.3044002538608 0.310344827586207 25.3 25 3 increased sensitivity to induced morbidity/mortality 8.94339030607212e-05 0.00202242576239585 1.30203720992265 0.309782608695652 25.3 25 3 decreased circulating calcium level 0.0257912092939071 0.147145947519711 1.2991299498048 0.309090909090909 25.3 25 3 small testis 2.61571000521017e-06 9.93370784421421e-05 1.29442295723304 0.307971014492754 25.3 25 3 increased susceptibility to injury 0.0312441817093509 0.167319487625426 1.29325153374233 0.307692307692308 25.3 25 3 increased autoantibody level 0.0574576168977555 0.244526641630739 1.29325153374233 0.307692307692308 25.3 25 3 decreased trabecular bone volume 0.0574576168977555 0.244526641630739 1.29325153374233 0.307692307692308 25.3 25 3 abnormal nasal bone morphology 0.109818345642061 0.376271535516013 1.29325153374233 0.307692307692308 25.3 25 3 small seminal vesicle 0.109818345642061 0.376271535516013 1.29325153374233 0.307692307692308 25.3 25 3 no spontaneous movement 0.109818345642061 0.376271535516013 1.29325153374233 0.307692307692308 25.3 25 3 abnormal ocular fundus morphology 0.109818345642061 0.376271535516013 1.29325153374233 0.307692307692308 25.3 25 3 hyperglycemia 0.00669347606321768 0.0585238021344603 1.28957752370329 0.306818181818182 25.3 25 3 increased circulating LDL cholesterol level 0.0378979990635836 0.184664588972897 1.2866533116314 0.306122448979592 25.3 25 3 abnormal epidermis stratum corneum morphology 0.0378979990635836 0.184664588972897 1.2866533116314 0.306122448979592 25.3 25 3 abnormal respiratory system physiology 0.0378979990635836 0.184664588972897 1.2866533116314 0.306122448979592 25.3 25 3 impaired wound healing 0.0702954431956039 0.288026951429388 1.28427062031356 0.305555555555556 25.3 25 3 increased circulating glucose level 0.00087522313969134 0.0129590330951322 1.28178653787582 0.304964539007092 25.3 25 3 abnormal spermatogenesis 0.000172372516189855 0.00352902579442193 1.27919445185383 0.304347826086957 25.3 25 3 abnormal sleep pattern 0.0460337033086368 0.214035209308849 1.27919445185383 0.304347826086957 25.3 25 3 delayed wound healing 0.0460337033086368 0.214035209308849 1.27919445185383 0.304347826086957 25.3 25 3 hypotension 0.136586589812444 0.441532348484023 1.27919445185383 0.304347826086957 25.3 25 3 pancreas inflammation 0.136586589812444 0.441532348484023 1.27919445185383 0.304347826086957 25.3 25 3 dilated heart 0.136586589812444 0.441532348484023 1.27919445185383 0.304347826086957 25.3 25 3 abnormal chondrocyte physiology 0.136586589812444 0.441532348484023 1.27919445185383 0.304347826086957 25.3 25 3 abnormal nervous system physiology 0.00260023357137922 0.0278307105055583 1.27919445185383 0.304347826086957 25.3 25 3 increased body weight 4.10084731493145e-05 0.00104624181496328 1.27593120070114 0.303571428571429 25.3 25 3 deafness 0.00539719497692874 0.0503771951411266 1.27365681353411 0.303030303030303 25.3 25 3 single kidney 0.0862293580909834 0.331523227590914 1.27365681353411 0.303030303030303 25.3 25 3 abnormal QRS complex 0.0862293580909834 0.331523227590914 1.27365681353411 0.303030303030303 25.3 25 3 increased osteoblast cell number 0.0862293580909834 0.331523227590914 1.27365681353411 0.303030303030303 25.3 25 3 abnormal blood circulation 0.0560043739730997 0.239745074627057 1.2706948209445 0.302325581395349 25.3 25 3 delayed endochondral bone ossification 0.0560043739730997 0.239745074627057 1.2706948209445 0.302325581395349 25.3 25 3 decreased oxygen consumption 0.0560043739730997 0.239745074627057 1.2706948209445 0.302325581395349 25.3 25 3 limb grasping 0.000239276072008856 0.00463190061573563 1.27015775635408 0.302197802197802 25.3 25 3 male infertility 1.71790705775897e-09 1.42443126872515e-07 1.27011184427179 0.302186878727634 25.3 25 3 abnormal hair follicle morphology 0.0247433348800021 0.144020875247524 1.26759178108871 0.301587301587302 25.3 25 3 skin lesions 0.0247433348800021 0.144020875247524 1.26759178108871 0.301587301587302 25.3 25 3 decreased grip strength 6.72719400848712e-05 0.00163257513132797 1.26667787209009 0.301369863013699 25.3 25 3 decreased anxiety-related response 0.00250468447966308 0.0269714400136879 1.26433737343508 0.300813008130081 25.3 25 3 neonatal lethality, complete penetrance 1.58157493649306e-08 1.04911137454039e-06 1.26276369604994 0.300438596491228 25.3 25 3 kidney inflammation 0.044825411935703 0.209789674863709 1.26092024539877 0.3 25.3 25 3 increased circulating chloride level 0.044825411935703 0.209789674863709 1.26092024539877 0.3 25.3 25 3 perinatal lethality 0.0682561922907743 0.282507950621133 1.26092024539877 0.3 25.3 25 3 abnormal cell proliferation 0.170953644502817 0.465167370189853 1.26092024539877 0.3 25.3 25 3 brain inflammation 0.170953644502817 0.465167370189853 1.26092024539877 0.3 25.3 25 3 abnormal hearing physiology 0.170953644502817 0.465167370189853 1.26092024539877 0.3 25.3 25 3 abnormal trachea morphology 0.170953644502817 0.465167370189853 1.26092024539877 0.3 25.3 25 3 abnormal postnatal subventricular zone morphology 0.170953644502817 0.465167370189853 1.26092024539877 0.3 25.3 25 3 abnormal incus morphology 0.170953644502817 0.465167370189853 1.26092024539877 0.3 25.3 25 3 abnormal induced retinal neovascularization 0.170953644502817 0.465167370189853 1.26092024539877 0.3 25.3 25 3 abnormal circulating cytokine level 0.170953644502817 0.465167370189853 1.26092024539877 0.3 25.3 25 3 salivary gland inflammation 0.106103356840405 0.369394121960123 1.26092024539877 0.3 25.3 25 3 abnormal lactation 0.106103356840405 0.369394121960123 1.26092024539877 0.3 25.3 25 3 abnormal spleen marginal zone morphology 0.106103356840405 0.369394121960123 1.26092024539877 0.3 25.3 25 3 abnormal fat pad morphology 0.106103356840405 0.369394121960123 1.26092024539877 0.3 25.3 25 3 increased B cell number 0.00355744063155299 0.0356819902055971 1.25732788002727 0.299145299145299 25.3 25 3 abnormal blood homeostasis 0.00423995212382277 0.0415207888823714 1.2535464427941 0.298245614035088 25.3 25 3 decreased bone trabecula number 0.0543610710768448 0.2343555707169 1.2519775486229 0.297872340425532 25.3 25 3 arrest of spermatogenesis 0.0132439737990608 0.0961879848909892 1.25091294186386 0.297619047619048 25.3 25 3 cataract 0.00347638728378955 0.0350101755806741 1.2504994169244 0.297520661157025 25.3 25 3 decreased width of hypertrophic chondrocyte zone 0.083356854035854 0.324491665749901 1.24956060354833 0.297297297297297 25.3 25 3 abnormal humerus morphology 0.083356854035854 0.324491665749901 1.24956060354833 0.297297297297297 25.3 25 3 abnormal kidney morphology 0.000540804621777227 0.00884630232964442 1.24891148115688 0.297142857142857 25.3 25 3 abnormal T cell differentiation 0.00736923758053677 0.0613076203397499 1.24843588653344 0.297029702970297 25.3 25 3 abnormal osteoclast physiology 0.0290257724208191 0.156909673722941 1.2477856595092 0.296875 25.3 25 3 increased sacral vertebrae number 0.0290257724208191 0.156909673722941 1.2477856595092 0.296875 25.3 25 3 increased blood urea nitrogen level 0.00161899463566189 0.0198876501541183 1.24642690924476 0.296551724137931 25.3 25 3 abnormal neuronal precursor proliferation 0.0435032567673848 0.203985581920584 1.24535332878891 0.296296296296296 25.3 25 3 abnormal trigeminal ganglion morphology 0.131039434848124 0.43432457586237 1.24535332878891 0.296296296296296 25.3 25 3 decreased liver weight 0.0234558063481124 0.142879491662361 1.24316080532273 0.295774647887324 25.3 25 3 increased T cell number 0.012894323864887 0.0941986214799011 1.24181539319576 0.295454545454545 25.3 25 3 reduced long term potentiation 0.00586773165629617 0.0522217620573765 1.23840381244522 0.294642857142857 25.3 25 3 abnormal trabecular bone morphology 0.00479952070573236 0.0460069663025404 1.2361963190184 0.294117647058824 25.3 25 3 abnormal gastrulation 0.0525991700334015 0.2271535337814 1.2361963190184 0.294117647058824 25.3 25 3 abnormal spleen red pulp morphology 0.102034493887813 0.356475847676874 1.2361963190184 0.294117647058824 25.3 25 3 decreased osteoblast cell number 0.102034493887813 0.356475847676874 1.2361963190184 0.294117647058824 25.3 25 3 distended urinary bladder 0.215721328867019 0.515968082266067 1.2361963190184 0.294117647058824 25.3 25 3 abnormal glutamate-mediated receptor currents 0.215721328867019 0.515968082266067 1.2361963190184 0.294117647058824 25.3 25 3 absence seizures 0.215721328867019 0.515968082266067 1.2361963190184 0.294117647058824 25.3 25 3 aminoaciduria 0.215721328867019 0.515968082266067 1.2361963190184 0.294117647058824 25.3 25 3 decreased growth hormone level 0.215721328867019 0.515968082266067 1.2361963190184 0.294117647058824 25.3 25 3 pancytopenia 0.215721328867019 0.515968082266067 1.2361963190184 0.294117647058824 25.3 25 3 common atrium 0.215721328867019 0.515968082266067 1.2361963190184 0.294117647058824 25.3 25 3 delayed heart development 0.215721328867019 0.515968082266067 1.2361963190184 0.294117647058824 25.3 25 3 abnormal cell cytoskeleton morphology 0.215721328867019 0.515968082266067 1.2361963190184 0.294117647058824 25.3 25 3 increased circulating insulin level 0.00126574922445195 0.0167031893677678 1.23465107361963 0.29375 25.3 25 3 postnatal lethality, complete penetrance 1.1306415697579e-06 4.72684185676098e-05 1.23043167297117 0.292746113989637 25.3 25 3 short humerus 0.0802900196677188 0.314027396106054 1.23016609307197 0.292682926829268 25.3 25 3 increased startle reflex 0.014962250528619 0.104107966964867 1.22786241124974 0.292134831460674 25.3 25 3 cochlear outer hair cell degeneration 0.0272807140381614 0.154580355740152 1.22589468302658 0.291666666666667 25.3 25 3 abnormal intestinal epithelium morphology 0.0636617019140343 0.263930805851934 1.22589468302658 0.291666666666667 25.3 25 3 abnormal foregut morphology 0.162556696600733 0.465167370189853 1.22589468302658 0.291666666666667 25.3 25 3 abnormal vasodilation 0.162556696600733 0.465167370189853 1.22589468302658 0.291666666666667 25.3 25 3 blindness 0.162556696600733 0.465167370189853 1.22589468302658 0.291666666666667 25.3 25 3 small lymph nodes 0.162556696600733 0.465167370189853 1.22589468302658 0.291666666666667 25.3 25 3 abnormal primitive streak formation 0.162556696600733 0.465167370189853 1.22589468302658 0.291666666666667 25.3 25 3 increased circulating total protein level 0.162556696600733 0.465167370189853 1.22589468302658 0.291666666666667 25.3 25 3 abnormal inner cell mass apoptosis 0.162556696600733 0.465167370189853 1.22589468302658 0.291666666666667 25.3 25 3 abnormal learning/memory/conditioning 0.0507697377821447 0.225138687671934 1.22271054099275 0.290909090909091 25.3 25 3 abnormal rostral-caudal axis patterning 0.0507697377821447 0.225138687671934 1.22271054099275 0.290909090909091 25.3 25 3 decreased startle reflex 0.00658939808135047 0.0580216910702984 1.2214042263122 0.290598290598291 25.3 25 3 abnormal T cell proliferation 0.125231976536865 0.41562980871975 1.22024539877301 0.290322580645161 25.3 25 3 decreased heart rate 0.0117896505738727 0.0884668350000249 1.21888957055215 0.29 25.3 25 3 increased bone marrow cell number 0.0978177981118865 0.342465549336126 1.21667742977075 0.289473684210526 25.3 25 3 short tail 0.0213302700529525 0.133097344868253 1.21534481484219 0.289156626506024 25.3 25 3 abnormal cartilage development 0.0771365980283515 0.302407072648581 1.21421949556919 0.288888888888889 25.3 25 3 abnormal ectoderm development 0.0771365980283515 0.302407072648581 1.21421949556919 0.288888888888889 25.3 25 3 increased circulating corticosterone level 0.0771365980283515 0.302407072648581 1.21421949556919 0.288888888888889 25.3 25 3 decreased IgM level 0.0140350798163383 0.101785017618489 1.21325659351085 0.288659793814433 25.3 25 3 cachexia 0.0114143294675444 0.0857798929018631 1.21242331288344 0.288461538461538 25.3 25 3 absent corpus luteum 0.061256597732341 0.257827050523178 1.21242331288344 0.288461538461538 25.3 25 3 abnormal skin condition 0.061256597732341 0.257827050523178 1.21242331288344 0.288461538461538 25.3 25 3 decreased kidney weight 0.061256597732341 0.257827050523178 1.21242331288344 0.288461538461538 25.3 25 3 abnormal colon morphology 0.0489095768777413 0.221108783860481 1.21105334303837 0.288135593220339 25.3 25 3 short limbs 0.0206067829162977 0.130597127399466 1.20777801283407 0.28735632183908 25.3 25 3 abnormal retinal pigmentation 0.0206067829162977 0.130597127399466 1.20777801283407 0.28735632183908 25.3 25 3 hydroencephaly 0.00899389488719155 0.0719507773318854 1.20609762603361 0.28695652173913 25.3 25 3 polyuria 0.0304158707283634 0.163765104841567 1.20087642418931 0.285714285714286 25.3 25 3 abnormal respiration 0.154184207620814 0.465167370189853 1.20087642418931 0.285714285714286 25.3 25 3 increased bone resorption 0.154184207620814 0.465167370189853 1.20087642418931 0.285714285714286 25.3 25 3 increased triglyceride level 0.154184207620814 0.465167370189853 1.20087642418931 0.285714285714286 25.3 25 3 decreased exploration in new environment 0.0245647885545092 0.144020875247524 1.20087642418931 0.285714285714286 25.3 25 3 abnormal long bone hypertrophic chondrocyte zone 0.0739671830542146 0.296763496527998 1.20087642418931 0.285714285714286 25.3 25 3 small ears 0.202760137566579 0.488489919803259 1.20087642418931 0.285714285714286 25.3 25 3 abnormal scapula morphology 0.202760137566579 0.488489919803259 1.20087642418931 0.285714285714286 25.3 25 3 increased acute inflammation 0.202760137566579 0.488489919803259 1.20087642418931 0.285714285714286 25.3 25 3 abnormal clavicle morphology 0.202760137566579 0.488489919803259 1.20087642418931 0.285714285714286 25.3 25 3 decreased birth weight 0.0191721405389779 0.123231781888133 1.19455602195673 0.284210526315789 25.3 25 3 increased circulating cholesterol level 0.00199671655411969 0.0229945945757997 1.19405326268823 0.284090909090909 25.3 25 3 increased liver weight 0.0236672825398733 0.142879491662361 1.19405326268823 0.284090909090909 25.3 25 3 increased neuron apoptosis 0.0292816017265451 0.157999965932279 1.19346360675604 0.283950617283951 25.3 25 3 abnormal kidney development 0.0564488872578903 0.240645427684665 1.1908691206544 0.283333333333333 25.3 25 3 abnormal eye physiology 0.0564488872578903 0.240645427684665 1.1908691206544 0.283333333333333 25.3 25 3 impaired coordination 2.46573465271903e-05 0.000681501660959842 1.19046420085819 0.283236994219653 25.3 25 3 abnormal coat/ hair morphology 0.0708284276240678 0.289779134399455 1.1895474013196 0.283018867924528 25.3 25 3 abnormal immune system morphology 0.0893892535239968 0.333302339578916 1.18782341957855 0.282608695652174 25.3 25 3 abnormal excitatory postsynaptic currents 0.0349015649785931 0.180853387173316 1.18548057259714 0.282051282051282 25.3 25 3 absent gastric milk in neonates 0.0349015649785931 0.180853387173316 1.18548057259714 0.282051282051282 25.3 25 3 reduced male fertility 0.000653312854005174 0.0101888133187327 1.18500581065377 0.281938325991189 25.3 25 3 decreased circulating LDL cholesterol level 0.0540964709198416 0.233417123006255 1.18211273006135 0.28125 25.3 25 3 abnormal depression-related behavior 0.146061179181483 0.457015324797409 1.18211273006135 0.28125 25.3 25 3 abnormal eye electrophysiology 0.0113249231325701 0.0857556964757019 1.18102722709527 0.28099173553719 25.3 25 3 abnormal developmental patterning 0.0335093117917176 0.177349815067867 1.17890917252731 0.280487804878049 25.3 25 3 hyperactivity 2.2769095424203e-05 0.000639978812064462 1.17821837844989 0.280323450134771 25.3 25 3 increased body length 0.0853000940447469 0.331523227590914 1.17685889570552 0.28 25.3 25 3 abnormal inner ear vestibule morphology 0.190530868266844 0.465167370189853 1.17685889570552 0.28 25.3 25 3 mandible hypoplasia 0.190530868266844 0.465167370189853 1.17685889570552 0.28 25.3 25 3 abnormal thyroid gland morphology 0.190530868266844 0.465167370189853 1.17685889570552 0.28 25.3 25 3 increased pre-B cell number 0.190530868266844 0.465167370189853 1.17685889570552 0.28 25.3 25 3 decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 0.190530868266844 0.465167370189853 1.17685889570552 0.28 25.3 25 3 impaired macrophage phagocytosis 0.10812176683436 0.371481899171921 1.17294906548723 0.27906976744186 25.3 25 3 abnormal axon guidance 0.10812176683436 0.371481899171921 1.17294906548723 0.27906976744186 25.3 25 3 abnormal response to infection 0.0398614046319413 0.192161325623942 1.1704744893997 0.278481012658228 25.3 25 3 abnormal myocardial fiber morphology 0.0249539687363549 0.144020875247524 1.16992600088546 0.278350515463918 25.3 25 3 diluted coat color 0.081338108722792 0.317129381579851 1.1675187457396 0.277777777777778 25.3 25 3 abnormal small intestine morphology 0.081338108722792 0.317129381579851 1.1675187457396 0.277777777777778 25.3 25 3 impaired limb coordination 0.081338108722792 0.317129381579851 1.1675187457396 0.277777777777778 25.3 25 3 axon degeneration 0.081338108722792 0.317129381579851 1.1675187457396 0.277777777777778 25.3 25 3 abnormal inflammatory response 0.0495672063556334 0.221759758650428 1.1675187457396 0.277777777777778 25.3 25 3 abnormal uterus morphology 0.138287008564943 0.446159447218282 1.1675187457396 0.277777777777778 25.3 25 3 reduced long term depression 0.138287008564943 0.446159447218282 1.1675187457396 0.277777777777778 25.3 25 3 renal hypoplasia 0.138287008564943 0.446159447218282 1.1675187457396 0.277777777777778 25.3 25 3 abnormal stomach glandular epithelium morphology 0.254655047858321 0.568630548965507 1.1675187457396 0.277777777777778 25.3 25 3 absent allantois 0.254655047858321 0.568630548965507 1.1675187457396 0.277777777777778 25.3 25 3 absent ureter 0.254655047858321 0.568630548965507 1.1675187457396 0.277777777777778 25.3 25 3 abnormal neutrophil morphology 0.254655047858321 0.568630548965507 1.1675187457396 0.277777777777778 25.3 25 3 jerky movement 0.254655047858321 0.568630548965507 1.1675187457396 0.277777777777778 25.3 25 3 atrioventricular block 0.254655047858321 0.568630548965507 1.1675187457396 0.277777777777778 25.3 25 3 abnormal aerobic respiration 0.254655047858321 0.568630548965507 1.1675187457396 0.277777777777778 25.3 25 3 decreased monocyte cell number 0.0618542690194335 0.259759783880506 1.1639263803681 0.276923076923077 25.3 25 3 azoospermia 0.00599595413180631 0.0532676282245293 1.16311301462361 0.276729559748428 25.3 25 3 abnormal T-helper 1 physiology 0.102782382106731 0.358836737530518 1.16255058086412 0.276595744680851 25.3 25 3 increased total body fat amount 0.0114120423174306 0.0857798929018631 1.16054848457101 0.276119402985075 25.3 25 3 abnormal microglial cell morphology 0.179115230262908 0.465167370189853 1.15946689232071 0.275862068965517 25.3 25 3 abnormal circulating glucose level 0.179115230262908 0.465167370189853 1.15946689232071 0.275862068965517 25.3 25 3 focal hair loss 0.179115230262908 0.465167370189853 1.15946689232071 0.275862068965517 25.3 25 3 abnormal spinal nerve morphology 0.179115230262908 0.465167370189853 1.15946689232071 0.275862068965517 25.3 25 3 aphagia 0.179115230262908 0.465167370189853 1.15946689232071 0.275862068965517 25.3 25 3 abnormal epidermal layer morphology 0.0590551798598663 0.250468473830209 1.15736640882013 0.27536231884058 25.3 25 3 abnormal pancreatic beta cell morphology 0.130900869943315 0.434154551978662 1.15584355828221 0.275 25.3 25 3 increased grip strength 0.0349752716892467 0.180853387173316 1.1546888694128 0.274725274725275 25.3 25 3 alopecia 0.0334588233964422 0.177271188921512 1.15031320632871 0.273684210526316 25.3 25 3 abnormal lens morphology 0.015776673298694 0.10785586805216 1.14927626533742 0.2734375 25.3 25 3 teratozoospermia 0.0413791114016731 0.199284684630517 1.1462911321807 0.272727272727273 25.3 25 3 abnormal tail morphology 0.0703422604998405 0.288026951429388 1.1462911321807 0.272727272727273 25.3 25 3 osteoporosis 0.123911694022068 0.411522481815613 1.1462911321807 0.272727272727273 25.3 25 3 abnormal astrocyte morphology 0.123911694022068 0.411522481815613 1.1462911321807 0.272727272727273 25.3 25 3 abnormal photoreceptor outer segment morphology 0.123911694022068 0.411522481815613 1.1462911321807 0.272727272727273 25.3 25 3 decreased systemic arterial blood pressure 0.168498112090421 0.465167370189853 1.1462911321807 0.272727272727273 25.3 25 3 diarrhea 0.168498112090421 0.465167370189853 1.1462911321807 0.272727272727273 25.3 25 3 intestinal ulcer 0.236485229757888 0.5543467296217 1.1462911321807 0.272727272727273 25.3 25 3 intestinal inflammation 0.236485229757888 0.5543467296217 1.1462911321807 0.272727272727273 25.3 25 3 testis hypoplasia 0.236485229757888 0.5543467296217 1.1462911321807 0.272727272727273 25.3 25 3 increased coping response 0.236485229757888 0.5543467296217 1.1462911321807 0.272727272727273 25.3 25 3 parakeratosis 0.236485229757888 0.5543467296217 1.1462911321807 0.272727272727273 25.3 25 3 abnormal blood-brain barrier function 0.236485229757888 0.5543467296217 1.1462911321807 0.272727272727273 25.3 25 3 increased bone volume 0.236485229757888 0.5543467296217 1.1462911321807 0.272727272727273 25.3 25 3 increased exploration in new environment 0.0513004370198095 0.225138687671934 1.14157388472317 0.271604938271605 25.3 25 3 increased rib number 0.0607318054628563 0.256268644764809 1.13159509202454 0.269230769230769 25.3 25 3 abnormal hair growth 0.111090139400427 0.379583409009014 1.13159509202454 0.269230769230769 25.3 25 3 abnormal female meiosis 0.111090139400427 0.379583409009014 1.13159509202454 0.269230769230769 25.3 25 3 increased percent body fat/body weight 0.111090139400427 0.379583409009014 1.13159509202454 0.269230769230769 25.3 25 3 abnormal leukocyte cell number 0.220267060812817 0.524570908350295 1.13159509202454 0.269230769230769 25.3 25 3 abnormal kidney cortex morphology 0.220267060812817 0.524570908350295 1.13159509202454 0.269230769230769 25.3 25 3 abnormal ureter morphology 0.220267060812817 0.524570908350295 1.13159509202454 0.269230769230769 25.3 25 3 decreased circulating glycerol level 0.220267060812817 0.524570908350295 1.13159509202454 0.269230769230769 25.3 25 3 abnormal nerve conduction 0.220267060812817 0.524570908350295 1.13159509202454 0.269230769230769 25.3 25 3 decreased compact bone thickness 0.0795795400056692 0.311493478779075 1.12918230931233 0.26865671641791 25.3 25 3 maternal effect 0.0795795400056692 0.311493478779075 1.12918230931233 0.26865671641791 25.3 25 3 female infertility 0.00175900254855879 0.0213439943392195 1.12187139628212 0.266917293233083 25.3 25 3 cardiomyopathy 0.140920819837965 0.452179903678779 1.12081799591002 0.266666666666667 25.3 25 3 abnormal response to new environment 0.205665002416546 0.494291491315129 1.12081799591002 0.266666666666667 25.3 25 3 abnormal immune system physiology 0.0272757641017481 0.154580355740152 1.11855828220859 0.266129032258065 25.3 25 3 decreased circulating creatinine level 0.132965547862004 0.437337361676261 1.11509953674721 0.26530612244898 25.3 25 3 abnormal lipid level 0.0649092580164656 0.268878899776783 1.11406608027201 0.265060240963855 25.3 25 3 abnormal oocyte morphology 0.19242501464336 0.465167370189853 1.11257668711656 0.264705882352941 25.3 25 3 decreased regulatory T cell number 0.19242501464336 0.465167370189853 1.11257668711656 0.264705882352941 25.3 25 3 abnormal B cell differentiation 0.0586701538429646 0.249047794683233 1.10850131463628 0.263736263736264 25.3 25 3 abnormal retinal outer nuclear layer morphology 0.180350693146133 0.465167370189853 1.10607039070068 0.263157894736842 25.3 25 3 stereotypic behavior 0.295094167238865 0.643402166951472 1.10607039070068 0.263157894736842 25.3 25 3 altered susceptibility to infection 0.295094167238865 0.643402166951472 1.10607039070068 0.263157894736842 25.3 25 3 abnormal photoreceptor inner segment morphology 0.295094167238865 0.643402166951472 1.10607039070068 0.263157894736842 25.3 25 3 decreased liver regeneration 0.295094167238865 0.643402166951472 1.10607039070068 0.263157894736842 25.3 25 3 increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 0.295094167238865 0.643402166951472 1.10607039070068 0.263157894736842 25.3 25 3 right-sided stomach 0.295094167238865 0.643402166951472 1.10607039070068 0.263157894736842 25.3 25 3 increased or absent threshold for auditory brainstem response 0.00192764696262689 0.0222506812971434 1.10530494406351 0.262975778546713 25.3 25 3 hydronephrosis 0.0725732363104486 0.293776932989814 1.1008033888402 0.261904761904762 25.3 25 3 short femur 0.0688990167448695 0.284559014950074 1.09852900167317 0.261363636363636 25.3 25 3 hyperkeratosis 0.100354000297172 0.3510978561733 1.09645238730328 0.260869565217391 25.3 25 3 abnormal inner ear morphology 0.159108431478189 0.465167370189853 1.09645238730328 0.260869565217391 25.3 25 3 abnormal cranial nerve morphology 0.271743573268045 0.601389802939735 1.09645238730328 0.260869565217391 25.3 25 3 bidirectional circling 0.271743573268045 0.601389802939735 1.09645238730328 0.260869565217391 25.3 25 3 abnormal cochlear ganglion morphology 0.271743573268045 0.601389802939735 1.09645238730328 0.260869565217391 25.3 25 3 abnormal cardiovascular development 0.271743573268045 0.601389802939735 1.09645238730328 0.260869565217391 25.3 25 3 abnormal ulna morphology 0.271743573268045 0.601389802939735 1.09645238730328 0.260869565217391 25.3 25 3 abnormal lens development 0.271743573268045 0.601389802939735 1.09645238730328 0.260869565217391 25.3 25 3 decreased effector memory CD8-positive, alpha-beta T cell number 0.271743573268045 0.601389802939735 1.09645238730328 0.260869565217391 25.3 25 3 abnormal hindlimb morphology 0.149712869473472 0.465167370189853 1.09279754601227 0.26 25.3 25 3 abnormal cochlea morphology 0.141014795075373 0.452179903678779 1.0896841626903 0.259259259259259 25.3 25 3 abnormal type II pneumocyte morphology 0.25149672990046 0.564364560782493 1.0896841626903 0.259259259259259 25.3 25 3 decreased susceptibility to pharmacologically induced seizures 0.25149672990046 0.564364560782493 1.0896841626903 0.259259259259259 25.3 25 3 abnormal eyelid morphology 0.233641707070348 0.551669431739431 1.08466257668712 0.258064516129032 25.3 25 3 abnormal nose morphology 0.233641707070348 0.551669431739431 1.08466257668712 0.258064516129032 25.3 25 3 abnormal humoral immune response 0.0621743662814068 0.259759783880506 1.08078878177038 0.257142857142857 25.3 25 3 thick epidermis 0.111904185724611 0.381075426601022 1.08078878177038 0.257142857142857 25.3 25 3 abnormal intestinal goblet cell morphology 0.217702744186787 0.519707846607133 1.08078878177038 0.257142857142857 25.3 25 3 holoprosencephaly 0.217702744186787 0.519707846607133 1.08078878177038 0.257142857142857 25.3 25 3 impaired behavioral response to xenobiotic 0.217702744186787 0.519707846607133 1.08078878177038 0.257142857142857 25.3 25 3 impaired adaptive thermogenesis 0.217702744186787 0.519707846607133 1.08078878177038 0.257142857142857 25.3 25 3 small lens 0.203342799890018 0.488946558459564 1.07770961145194 0.256410256410256 25.3 25 3 acanthosis 0.203342799890018 0.488946558459564 1.07770961145194 0.256410256410256 25.3 25 3 abnormal leukocyte adhesion 0.203342799890018 0.488946558459564 1.07770961145194 0.256410256410256 25.3 25 3 abnormal circulating hormone level 0.203342799890018 0.488946558459564 1.07770961145194 0.256410256410256 25.3 25 3 increased susceptibility to parasitic infection 0.0849645007561947 0.330491314512955 1.07411724608044 0.255555555555556 25.3 25 3 abnormal cued conditioning behavior 0.167515840178417 0.465167370189853 1.07137014314928 0.254901960784314 25.3 25 3 abnormal response to novel object 0.167515840178417 0.465167370189853 1.07137014314928 0.254901960784314 25.3 25 3 seizures 0.0618860230398217 0.259759783880506 1.06920137767732 0.254385964912281 25.3 25 3 syndactyly 0.148207087191271 0.463438251902309 1.0685764791515 0.254237288135593 25.3 25 3 decreased food intake 0.110855778837559 0.379564693542225 1.0640677176361 0.253164556962025 25.3 25 3 small ovary 0.0938581769180227 0.338470670921745 1.06231375985977 0.252747252747253 25.3 25 3 increased thermal nociceptive threshold 0.0938581769180227 0.338470670921745 1.06231375985977 0.252747252747253 25.3 25 3 increased food intake 0.115564156865217 0.384827095317574 1.05076687116564 0.25 25.3 25 3 abnormal leukocyte migration 0.186324407104413 0.465167370189853 1.05076687116564 0.25 25.3 25 3 abnormal brain wave pattern 0.186324407104413 0.465167370189853 1.05076687116564 0.25 25.3 25 3 decreased body temperature 0.186324407104413 0.465167370189853 1.05076687116564 0.25 25.3 25 3 failure of primitive streak formation 0.262835216366636 0.585582266647566 1.05076687116564 0.25 25.3 25 3 increased circulating follicle stimulating hormone level 0.262835216366636 0.585582266647566 1.05076687116564 0.25 25.3 25 3 abnormal long term potentiation 0.262835216366636 0.585582266647566 1.05076687116564 0.25 25.3 25 3 abnormal stria vascularis morphology 0.283934237327008 0.621457470612347 1.05076687116564 0.25 25.3 25 3 rib bifurcation 0.283934237327008 0.621457470612347 1.05076687116564 0.25 25.3 25 3 abnormal circulating cholesterol level 0.283934237327008 0.621457470612347 1.05076687116564 0.25 25.3 25 3 hypoxia 0.283934237327008 0.621457470612347 1.05076687116564 0.25 25.3 25 3 corneal vascularization 0.283934237327008 0.621457470612347 1.05076687116564 0.25 25.3 25 3 abnormal nursing 0.308139198823815 0.65278942971143 1.05076687116564 0.25 25.3 25 3 increased stereotypic behavior 0.308139198823815 0.65278942971143 1.05076687116564 0.25 25.3 25 3 abnormal startle reflex 0.308139198823815 0.65278942971143 1.05076687116564 0.25 25.3 25 3 increased urine glucose level 0.336474341484214 0.65278942971143 1.05076687116564 0.25 25.3 25 3 abnormal dopamine level 0.336474341484214 0.65278942971143 1.05076687116564 0.25 25.3 25 3 abnormal sensory capabilities/reflexes/nociception 0.308139198823815 0.65278942971143 1.05076687116564 0.25 25.3 25 3 abnormal fibula morphology 0.336474341484214 0.65278942971143 1.05076687116564 0.25 25.3 25 3 abnormal Peyer's patch T cell area morphology 0.336474341484214 0.65278942971143 1.05076687116564 0.25 25.3 25 3 abnormal cardiac muscle contractility 0.308139198823815 0.65278942971143 1.05076687116564 0.25 25.3 25 3 abnormal lens epithelium morphology 0.336474341484214 0.65278942971143 1.05076687116564 0.25 25.3 25 3 abnormal thymocyte activation 0.336474341484214 0.65278942971143 1.05076687116564 0.25 25.3 25 3 abnormal retinal ganglion layer morphology 0.308139198823815 0.65278942971143 1.05076687116564 0.25 25.3 25 3 decreased fatty acid level 0.308139198823815 0.65278942971143 1.05076687116564 0.25 25.3 25 3 enhanced behavioral response to xenobiotic 0.336474341484214 0.65278942971143 1.05076687116564 0.25 25.3 25 3 abnormal limb bone morphology 0.244174656060735 0.5543467296217 1.05076687116564 0.25 25.3 25 3 abnormal trophoblast giant cell morphology 0.244174656060735 0.5543467296217 1.05076687116564 0.25 25.3 25 3 increased circulating HDL cholesterol level 0.09610939470227 0.338470670921745 1.04075956763073 0.247619047619048 25.3 25 3 obese 0.14251820744897 0.452893285946983 1.03712054816349 0.246753246753247 25.3 25 3 abnormal coat appearance 0.160484944114788 0.465167370189853 1.03553836578643 0.246376811594203 25.3 25 3 abnormal maternal nurturing 0.181415996093509 0.465167370189853 1.03354118475309 0.245901639344262 25.3 25 3 abnormal NK cell physiology 0.181415996093509 0.465167370189853 1.03354118475309 0.245901639344262 25.3 25 3 decreased susceptibility to induced arthritis 0.193221468052798 0.466639225030423 1.03233236465397 0.245614035087719 25.3 25 3 abnormal circulating amino acid level 0.193221468052798 0.466639225030423 1.03233236465397 0.245614035087719 25.3 25 3 abnormal spatial learning 0.0548521005787061 0.236267705955899 1.03142760359818 0.245398773006135 25.3 25 3 cardiac hypertrophy 0.117290258081434 0.390313735087045 1.02932264930512 0.244897959183673 25.3 25 3 abnormal autopod morphology 0.235586374417647 0.5543467296217 1.02741649625085 0.244444444444444 25.3 25 3 decreased osteoclast cell number 0.235586374417647 0.5543467296217 1.02741649625085 0.244444444444444 25.3 25 3 scaly skin 0.252661699601677 0.566212592575831 1.02513841089331 0.24390243902439 25.3 25 3 short ulna 0.252661699601677 0.566212592575831 1.02513841089331 0.24390243902439 25.3 25 3 abnormal cholesterol homeostasis 0.252661699601677 0.566212592575831 1.02513841089331 0.24390243902439 25.3 25 3 small seminiferous tubules 0.165753662238884 0.465167370189853 1.02236776653955 0.243243243243243 25.3 25 3 increased brown adipose tissue amount 0.271670667216634 0.601389802939735 1.02236776653955 0.243243243243243 25.3 25 3 increased white adipose tissue amount 0.271670667216634 0.601389802939735 1.02236776653955 0.243243243243243 25.3 25 3 abnormal long bone metaphysis morphology 0.271670667216634 0.601389802939735 1.02236776653955 0.243243243243243 25.3 25 3 abnormal vocalization 0.271670667216634 0.601389802939735 1.02236776653955 0.243243243243243 25.3 25 3 decreased circulating chloride level 0.271670667216634 0.601389802939735 1.02236776653955 0.243243243243243 25.3 25 3 increased insulin secretion 0.271670667216634 0.601389802939735 1.02236776653955 0.243243243243243 25.3 25 3 abnormal hair follicle development 0.271670667216634 0.601389802939735 1.02236776653955 0.243243243243243 25.3 25 3 dehydration 0.176067451522957 0.465167370189853 1.02074496056091 0.242857142857143 25.3 25 3 impaired swimming 0.187210729725052 0.465167370189853 1.01892545082729 0.242424242424242 25.3 25 3 abnormal T cell subpopulation ratio 0.293023089735025 0.640837819526923 1.01892545082729 0.242424242424242 25.3 25 3 impaired righting response 0.135283148616418 0.438458413268194 1.01758475944462 0.242105263157895 25.3 25 3 increased eosinophil cell number 0.199282689060407 0.481043851565028 1.01687116564417 0.241935483870968 25.3 25 3 decreased granulocyte number 0.317285739574676 0.65278942971143 1.01453353078062 0.241379310344828 25.3 25 3 increased susceptibility to induced arthritis 0.317285739574676 0.65278942971143 1.01453353078062 0.241379310344828 25.3 25 3 short sternum 0.317285739574676 0.65278942971143 1.01453353078062 0.241379310344828 25.3 25 3 increased double-positive T cell number 0.317285739574676 0.65278942971143 1.01453353078062 0.241379310344828 25.3 25 3 increased retinal apoptosis 0.317285739574676 0.65278942971143 1.01453353078062 0.241379310344828 25.3 25 3 polyphagia 0.226708250284692 0.539652413955187 1.01184957964099 0.240740740740741 25.3 25 3 abnormal nest building behavior 0.34527867163128 0.65278942971143 1.00873619631902 0.24 25.3 25 3 abnormal primitive streak morphology 0.34527867163128 0.65278942971143 1.00873619631902 0.24 25.3 25 3 abnormal egg cylinder morphology 0.34527867163128 0.65278942971143 1.00873619631902 0.24 25.3 25 3 decreased acute inflammation 0.34527867163128 0.65278942971143 1.00873619631902 0.24 25.3 25 3 abnormal energy expenditure 0.34527867163128 0.65278942971143 1.00873619631902 0.24 25.3 25 3 abnormal CD4-positive, alpha-beta T cell physiology 0.192386876115521 0.465167370189853 1.00636827097555 0.23943661971831 25.3 25 3 abnormal lymphocyte physiology 0.259622299341477 0.579202214898586 1.00508135502801 0.239130434782609 25.3 25 3 abnormal salivary gland morphology 0.378260030208474 0.700351191026111 1.00073035349109 0.238095238095238 25.3 25 3 abnormal embryonic/fetal subventricular zone morphology 0.378260030208474 0.700351191026111 1.00073035349109 0.238095238095238 25.3 25 3 abnormal stapes morphology 0.378260030208474 0.700351191026111 1.00073035349109 0.238095238095238 25.3 25 3 increased keratinocyte proliferation 0.378260030208474 0.700351191026111 1.00073035349109 0.238095238095238 25.3 25 3 increased bone ossification 0.378260030208474 0.700351191026111 1.00073035349109 0.238095238095238 25.3 25 3 hyporesponsive to tactile stimuli 0.300011348824721 0.645569403288489 0.99546335163061 0.236842105263158 25.3 25 3 decreased threshold for auditory brainstem response 0.300011348824721 0.645569403288489 0.99546335163061 0.236842105263158 25.3 25 3 decreased cytotoxic T cell cytolysis 0.323976343609383 0.65278942971143 0.988957055214724 0.235294117647059 25.3 25 3 increased susceptibility to weight gain 0.323976343609383 0.65278942971143 0.988957055214724 0.235294117647059 25.3 25 3 decreased caudal vertebrae number 0.237293528329713 0.5543467296217 0.985093941717792 0.234375 25.3 25 3 epidermal hyperplasia 0.253067212688251 0.56686599870511 0.980715746421268 0.233333333333333 25.3 25 3 abnormal pain threshold 0.351257268274977 0.659684752611555 0.980715746421268 0.233333333333333 25.3 25 3 abnormal male reproductive system morphology 0.305505425601828 0.65278942971143 0.977457554572692 0.232558139534884 25.3 25 3 abnormal locomotor activation 0.208428351524574 0.500690994125909 0.969938650306748 0.230769230769231 25.3 25 3 abnormal heart looping 0.329011913505131 0.65278942971143 0.969938650306748 0.230769230769231 25.3 25 3 abnormal iris morphology 0.329011913505131 0.65278942971143 0.969938650306748 0.230769230769231 25.3 25 3 decreased B-1 B cell number 0.329011913505131 0.65278942971143 0.969938650306748 0.230769230769231 25.3 25 3 abnormal male meiosis 0.274410128269664 0.603719463804137 0.964638439102886 0.229508196721311 25.3 25 3 impaired natural killer cell mediated cytotoxicity 0.293046440085176 0.640837819526923 0.958594338607254 0.228070175438596 25.3 25 3 hypertension 0.332875872684603 0.65278942971143 0.955242610150586 0.227272727272727 25.3 25 3 abnormal gametogenesis 0.332875872684603 0.65278942971143 0.955242610150586 0.227272727272727 25.3 25 3 abnormal amino acid level 0.332875872684603 0.65278942971143 0.955242610150586 0.227272727272727 25.3 25 3 increased activated T cell number 0.419958500929235 0.753169986345691 0.955242610150586 0.227272727272727 25.3 25 3 abnormal chorion morphology 0.419958500929235 0.753169986345691 0.955242610150586 0.227272727272727 25.3 25 3 abnormal channel response 0.419958500929235 0.753169986345691 0.955242610150586 0.227272727272727 25.3 25 3 abnormal female reproductive system physiology 0.419958500929235 0.753169986345691 0.955242610150586 0.227272727272727 25.3 25 3 abnormal limb posture 0.419958500929235 0.753169986345691 0.955242610150586 0.227272727272727 25.3 25 3 decreased susceptibility to viral infection induced morbidity/mortality 0.419958500929235 0.753169986345691 0.955242610150586 0.227272727272727 25.3 25 3 abnormal CD8-positive, alpha beta T cell morphology 0.38556180695966 0.713604906854282 0.949079754601227 0.225806451612903 25.3 25 3 decreased circulating phosphate level 0.35848598552758 0.669469886636528 0.94569018404908 0.225 25.3 25 3 impaired ovarian folliculogenesis 0.35848598552758 0.669469886636528 0.94569018404908 0.225 25.3 25 3 decreased urine osmolality 0.335878692475149 0.65278942971143 0.943545761863027 0.224489795918367 25.3 25 3 abnormal spermiogenesis 0.316343944409265 0.65278942971143 0.942066850010577 0.224137931034483 25.3 25 3 abnormal CNS synaptic transmission 0.25876737582421 0.577553923160809 0.934014996591684 0.222222222222222 25.3 25 3 cryptorchism 0.420292276298635 0.75349696381467 0.934014996591684 0.222222222222222 25.3 25 3 abnormal metabolism 0.360672872189448 0.673301140391184 0.934014996591684 0.222222222222222 25.3 25 3 increased susceptibility to bacterial infection induced morbidity/mortality 0.301423493641129 0.648327661420067 0.934014996591684 0.222222222222222 25.3 25 3 head tilt 0.387262006498557 0.71645641226642 0.934014996591684 0.222222222222222 25.3 25 3 decreased oocyte number 0.362250979091983 0.67599348123879 0.924674846625767 0.22 25.3 25 3 abnormal crypts of Lieberkuhn morphology 0.419925252325706 0.753169986345691 0.919421012269939 0.21875 25.3 25 3 abnormal food intake 0.342644859453992 0.65278942971143 0.913710322752734 0.217391304347826 25.3 25 3 abnormal retinal cone cell morphology 0.461129314168455 0.776782869960379 0.913710322752734 0.217391304347826 25.3 25 3 abnormal innervation pattern to muscle 0.461129314168455 0.776782869960379 0.913710322752734 0.217391304347826 25.3 25 3 blistering 0.461129314168455 0.776782869960379 0.913710322752734 0.217391304347826 25.3 25 3 abnormal circulating insulin level 0.461129314168455 0.776782869960379 0.913710322752734 0.217391304347826 25.3 25 3 failure of embryo implantation 0.461129314168455 0.776782869960379 0.913710322752734 0.217391304347826 25.3 25 3 abnormal nasal cavity morphology 0.461129314168455 0.776782869960379 0.913710322752734 0.217391304347826 25.3 25 3 abnormal Wolffian duct morphology 0.461129314168455 0.776782869960379 0.913710322752734 0.217391304347826 25.3 25 3 decreased epididymis weight 0.461129314168455 0.776782869960379 0.913710322752734 0.217391304347826 25.3 25 3 increased susceptibility to fungal infection 0.461129314168455 0.776782869960379 0.913710322752734 0.217391304347826 25.3 25 3 abnormal long bone epiphyseal plate morphology 0.364140901523191 0.67926546122155 0.910664621676892 0.216666666666667 25.3 25 3 abnormal suckling behavior 0.325588668552766 0.65278942971143 0.907480479643056 0.215909090909091 25.3 25 3 increased anxiety-related response 0.269406216293381 0.599953413634543 0.907136867193362 0.215827338129496 25.3 25 3 abnormal jaw morphology 0.457480832381806 0.776782869960379 0.900657318141981 0.214285714285714 25.3 25 3 reddish skin 0.457480832381806 0.776782869960379 0.900657318141981 0.214285714285714 25.3 25 3 abnormal optic nerve morphology 0.418121627874159 0.752127359068076 0.900657318141981 0.214285714285714 25.3 25 3 abnormal innervation 0.416933943299062 0.75072253634196 0.894269677587782 0.212765957446809 25.3 25 3 abnormal social investigation 0.36495761628175 0.680278808917837 0.893151840490798 0.2125 25.3 25 3 head tossing 0.454091219177045 0.776782869960379 0.89155976947388 0.212121212121212 25.3 25 3 circling 0.364790765773339 0.680222661065353 0.890061349693252 0.211764705882353 25.3 25 3 increased circulating free fatty acid level 0.387390502310888 0.71645641226642 0.887972003801953 0.211267605633803 25.3 25 3 increased grooming behavior 0.450919385489401 0.776782869960379 0.884856312560543 0.210526315789474 25.3 25 3 abnormal impulse conducting system conduction 0.501389870838097 0.821071299348102 0.875639059304703 0.208333333333333 25.3 25 3 abnormal excitatory postsynaptic potential 0.407115240911407 0.737850026788433 0.871367649259315 0.207317073170732 25.3 25 3 abnormal middle ear morphology 0.494053465288014 0.809323671322973 0.869600169240533 0.206896551724138 25.3 25 3 abnormal endoderm development 0.487824705435327 0.79938336941395 0.865337423312883 0.205882352941176 25.3 25 3 abnormal nervous system development 0.487824705435327 0.79938336941395 0.865337423312883 0.205882352941176 25.3 25 3 increased fluid intake 0.473107756859979 0.776782869960379 0.857768874420934 0.204081632653061 25.3 25 3 abnormal female reproductive system morphology 0.513352726442524 0.837354037393953 0.840613496932515 0.2 25.3 25 3 head bobbing 0.513352726442524 0.837354037393953 0.840613496932515 0.2 25.3 25 3 abnormal feces composition 0.540417670639802 0.867283197236456 0.840613496932515 0.2 25.3 25 3 decreased placenta weight 0.540417670639802 0.867283197236456 0.840613496932515 0.2 25.3 25 3 abnormal stomach mucosa morphology 0.540417670639802 0.867283197236456 0.840613496932515 0.2 25.3 25 3 impaired fertilization 0.481893988080167 0.790185428707591 0.840613496932515 0.2 25.3 25 3 irregular heartbeat 0.506728792832992 0.829541212354108 0.840613496932515 0.2 25.3 25 3 ovary cysts 0.520914677416065 0.848296147205571 0.840613496932515 0.2 25.3 25 3 decreased circulating thyroxine level 0.520914677416065 0.848296147205571 0.840613496932515 0.2 25.3 25 3 arrested T cell differentiation 0.529752514541273 0.859595159766091 0.840613496932515 0.2 25.3 25 3 abnormal estrous cycle 0.529752514541273 0.859595159766091 0.840613496932515 0.2 25.3 25 3 abnormal synaptic transmission 0.529752514541273 0.859595159766091 0.840613496932515 0.2 25.3 25 3 arrested B cell differentiation 0.54368088656332 0.872238765124966 0.820110728714649 0.195121951219512 25.3 25 3 abnormal reflex 0.553175666947878 0.876265960978124 0.817263122017723 0.194444444444444 25.3 25 3 narrow eye opening 0.553175666947878 0.876265960978124 0.817263122017723 0.194444444444444 25.3 25 3 absent mature ovarian follicles 0.564358284360861 0.876265960978124 0.813496932515337 0.193548387096774 25.3 25 3 autoimmune response 0.564358284360861 0.876265960978124 0.813496932515337 0.193548387096774 25.3 25 3 abnormal retinal photoreceptor layer morphology 0.564358284360861 0.876265960978124 0.813496932515337 0.193548387096774 25.3 25 3 abnormal intestine physiology 0.564358284360861 0.876265960978124 0.813496932515337 0.193548387096774 25.3 25 3 abnormal vibrissa morphology 0.573224241549005 0.876265960978124 0.800584282792872 0.19047619047619 25.3 25 3 abnormal enzyme/coenzyme level 0.572355375381697 0.876265960978124 0.797133488470489 0.189655172413793 25.3 25 3 abnormal lymphatic vessel morphology 0.597688984061281 0.905662816377088 0.788075153374233 0.1875 25.3 25 3 abnormal phalanx morphology 0.590813534112631 0.90134846127272 0.788075153374233 0.1875 25.3 25 3 abnormal intestinal mucosa morphology 0.60186251411703 0.907903580270535 0.781966043658154 0.186046511627907 25.3 25 3 abnormal action potential 0.60265595859307 0.908824914822832 0.78056967572305 0.185714285714286 25.3 25 3 embryonic lethality, incomplete penetrance 0.629494715319863 0.946429800156035 0.764194088120469 0.181818181818182 25.3 25 3 abnormal lens fiber morphology 0.643523536586048 0.95461078954602 0.75439672801636 0.179487179487179 25.3 25 3 enhanced coordination 0.647759568373951 0.95461078954602 0.750547765118317 0.178571428571429 25.3 25 3 abnormal ovarian follicle morphology 0.656038698560268 0.95461078954602 0.747211997273347 0.177777777777778 25.3 25 3 abnormal urine homeostasis 0.68637115550425 0.992932974304637 0.744293200408998 0.177083333333333 25.3 25 3 impaired synaptic plasticity 0.659979932703859 0.959497418235447 0.741717791411043 0.176470588235294 25.3 25 3 abnormal vision 0.659979932703859 0.959497418235447 0.741717791411043 0.176470588235294 25.3 25 3 abnormal skin physiology 0.659979932703859 0.959497418235447 0.741717791411043 0.176470588235294 25.3 25 3 abnormal skin pigmentation 0.671135526616492 0.971740176052691 0.735536809815951 0.175 25.3 25 3 stomach inflammation 0.679781673183522 0.98368639444096 0.724666807700444 0.172413793103448 25.3 25 3 enlarged epididymis 0.679781673183522 0.98368639444096 0.724666807700444 0.172413793103448 25.3 25 3 increased systemic arterial blood pressure 0.705622758723279 1 0.715415742070226 0.170212765957447 25.3 25 3 increased dopamine level 0.763692751348962 1 0.656729294478528 0.15625 25.3 25 3 abnormal serotonin level 0.763692751348962 1 0.656729294478528 0.15625 25.3 25 3 increased susceptibility to pharmacologically induced seizures 0.847849337442308 1 0.656729294478528 0.15625 25.3 25 3 abnormal nervous system electrophysiology 0.844273473944627 1 0.650474729769208 0.154761904761905 25.3 25 3 abnormal inhibitory postsynaptic currents 0.866224293108909 1 0.618098159509202 0.147058823529412 25.3 25 3 decreased pancreatic beta cell number 0.809647961445067 1 0.618098159509202 0.147058823529412 25.3 25 3 abnormal digestive system physiology 0.870728555095609 1 0.588429447852761 0.14 25.3 25 3 abnormal hair shaft morphology 0.966939991230945 1 0.437819529652352 0.104166666666667 25.3 25 3 early eyelid opening 6.92735142555505e-05 0.00120082137080615 2.30998146160601 1 26.2 26 2 abnormal foramen magnum morphology 6.92735142555505e-05 0.00120082137080615 2.30998146160601 1 26.2 26 2 decreased brain cholesterol level 0.000229403415642014 0.00320584829443545 2.30998146160601 1 26.2 26 2 absent ectoplacental cone 0.000759631460680057 0.00847346752664413 2.30998146160601 1 26.2 26 2 abnormal respiratory sounds 0.00251522252194522 0.0224251470370564 2.30998146160601 1 26.2 26 2 improved righting response 0.00251522252194522 0.0224251470370564 2.30998146160601 1 26.2 26 2 scapular bone foramen 0.00251522252194522 0.0224251470370564 2.30998146160601 1 26.2 26 2 increased Schwann cell number 0.00251522252194522 0.0224251470370564 2.30998146160601 1 26.2 26 2 delayed optic fissure closure 0.00251522252194522 0.0224251470370564 2.30998146160601 1 26.2 26 2 abnormal ciliary process morphology 0.00251522252194522 0.0224251470370564 2.30998146160601 1 26.2 26 2 abnormal radial glial cell morphology 5.04039503051553e-05 0.00092191048811819 2.09998314691455 0.909090909090909 26.2 26 2 thick aortic valve cusps 0.000152332478513275 0.00236829400188607 2.07898331544541 0.9 26.2 26 2 abnormal cerebellar layer morphology 0.000456123484770979 0.005687253976781 2.0533168547609 0.888888888888889 26.2 26 2 short ureter 0.00135031272534725 0.0137098077726584 2.02123377890526 0.875 26.2 26 2 abnormal soft palate morphology 0.00135031272534725 0.0137098077726584 2.02123377890526 0.875 26.2 26 2 abnormal vertebral body development 0.00135031272534725 0.0137098077726584 2.02123377890526 0.875 26.2 26 2 increased brain apoptosis 0.00135031272534725 0.0137098077726584 2.02123377890526 0.875 26.2 26 2 abnormal glial cell morphology 9.45800160920328e-06 0.000226219028873973 2.00198393339188 0.866666666666667 26.2 26 2 increased hemangioma incidence 2.72807661037532e-05 0.00056550754735905 1.97998410994801 0.857142857142857 26.2 26 2 sternebra fusion 2.72807661037532e-05 0.00056550754735905 1.97998410994801 0.857142857142857 26.2 26 2 mammary gland hyperplasia 0.00394099973090831 0.0311708643263416 1.97998410994801 0.857142857142857 26.2 26 2 retina hyperplasia 0.00394099973090831 0.0311708643263416 1.97998410994801 0.857142857142857 26.2 26 2 abnormal tumor incidence 0.00394099973090831 0.0311708643263416 1.97998410994801 0.857142857142857 26.2 26 2 absent tunnel of Corti 0.00394099973090831 0.0311708643263416 1.97998410994801 0.857142857142857 26.2 26 2 aorta coarctation 0.00394099973090831 0.0311708643263416 1.97998410994801 0.857142857142857 26.2 26 2 abnormal Purkinje cell innervation 0.00394099973090831 0.0311708643263416 1.97998410994801 0.857142857142857 26.2 26 2 abnormal optic tract morphology 0.00394099973090831 0.0311708643263416 1.97998410994801 0.857142857142857 26.2 26 2 abnormal cerebellum white matter morphology 0.00394099973090831 0.0311708643263416 1.97998410994801 0.857142857142857 26.2 26 2 increased oligodendrocyte number 0.00394099973090831 0.0311708643263416 1.97998410994801 0.857142857142857 26.2 26 2 heart block 0.00394099973090831 0.0311708643263416 1.97998410994801 0.857142857142857 26.2 26 2 abnormal aortic valve cusp morphology 0.00394099973090831 0.0311708643263416 1.97998410994801 0.857142857142857 26.2 26 2 increased compact bone volume 0.00394099973090831 0.0311708643263416 1.97998410994801 0.857142857142857 26.2 26 2 ductus venosus stenosis 0.00394099973090831 0.0311708643263416 1.97998410994801 0.857142857142857 26.2 26 2 increased cochlear inner hair cell number 7.78796507081839e-05 0.0013348897271717 1.95459969828201 0.846153846153846 26.2 26 2 abnormal superior cervical ganglion morphology 0.000219678703605697 0.00310483395010892 1.92498455133834 0.833333333333333 26.2 26 2 abnormal respiratory function 0.000219678703605697 0.00310483395010892 1.92498455133834 0.833333333333333 26.2 26 2 abnormal AMPA-mediated synaptic currents 0.000219678703605697 0.00310483395010892 1.92498455133834 0.833333333333333 26.2 26 2 decreased red blood cell distribution width 0.000219678703605697 0.00310483395010892 1.92498455133834 0.833333333333333 26.2 26 2 abnormal pulmonary valve cusp morphology 0.000219678703605697 0.00310483395010892 1.92498455133834 0.833333333333333 26.2 26 2 delayed brain development 0.011293177828271 0.0669649102451113 1.92498455133834 0.833333333333333 26.2 26 2 abnormal parental behavior 0.011293177828271 0.0669649102451113 1.92498455133834 0.833333333333333 26.2 26 2 decreased liver function 0.011293177828271 0.0669649102451113 1.92498455133834 0.833333333333333 26.2 26 2 abnormal common crus morphology 0.011293177828271 0.0669649102451113 1.92498455133834 0.833333333333333 26.2 26 2 abnormal aorta tunica adventitia morphology 0.011293177828271 0.0669649102451113 1.92498455133834 0.833333333333333 26.2 26 2 abnormal olfactory bulb layer morphology 0.011293177828271 0.0669649102451113 1.92498455133834 0.833333333333333 26.2 26 2 thick pulmonary valve cusps 0.011293177828271 0.0669649102451113 1.92498455133834 0.833333333333333 26.2 26 2 abnormal ureteric bud tip morphology 0.011293177828271 0.0669649102451113 1.92498455133834 0.833333333333333 26.2 26 2 ciliary body hypoplasia 0.011293177828271 0.0669649102451113 1.92498455133834 0.833333333333333 26.2 26 2 abnormal vertebral artery origin 0.011293177828271 0.0669649102451113 1.92498455133834 0.833333333333333 26.2 26 2 abnormal excitatory synapse morphology 0.011293177828271 0.0669649102451113 1.92498455133834 0.833333333333333 26.2 26 2 absent ureter 4.7714385170645e-06 0.000125597389536486 1.92498455133834 0.833333333333333 26.2 26 2 darkened coat color 4.7714385170645e-06 0.000125597389536486 1.92498455133834 0.833333333333333 26.2 26 2 increased brain size 1.32451563527999e-05 0.000300888825822738 1.90233767426377 0.823529411764706 26.2 26 2 abnormal sphenoid bone morphology 0.000611010855449813 0.00720326778640478 1.8899848322231 0.818181818181818 26.2 26 2 fatigue 0.000611010855449813 0.00720326778640478 1.8899848322231 0.818181818181818 26.2 26 2 abnormal spinal cord ventral horn morphology 0.000611010855449813 0.00720326778640478 1.8899848322231 0.818181818181818 26.2 26 2 increased cochlear outer hair cell number 3.63611305912887e-05 0.000706627440201802 1.87685993755488 0.8125 26.2 26 2 abnormal placenta size 9.85718240819529e-05 0.00160785188461546 1.84798516928481 0.8 26.2 26 2 heterochrony 9.85718240819529e-05 0.00160785188461546 1.84798516928481 0.8 26.2 26 2 alcohol preference 0.00167128750980179 0.0159897218485844 1.84798516928481 0.8 26.2 26 2 ketoaciduria 0.00167128750980179 0.0159897218485844 1.84798516928481 0.8 26.2 26 2 impaired basement membrane formation 0.00167128750980179 0.0159897218485844 1.84798516928481 0.8 26.2 26 2 bifid ureter 0.00167128750980179 0.0159897218485844 1.84798516928481 0.8 26.2 26 2 increased heart rate variability 0.00167128750980179 0.0159897218485844 1.84798516928481 0.8 26.2 26 2 decreased transitional stage T2 B cell number 0.00167128750980179 0.0159897218485844 1.84798516928481 0.8 26.2 26 2 unresponsive to tactile stimuli 1.62820342588029e-05 0.000363242692545042 1.82366957495211 0.789473684210526 26.2 26 2 abnormal voluntary movement 0.000263408894257762 0.00358048975118133 1.81498543411901 0.785714285714286 26.2 26 2 spina bifida occulta 0.000263408894257762 0.00358048975118133 1.81498543411901 0.785714285714286 26.2 26 2 abnormal vitelline vein topology 0.000263408894257762 0.00358048975118133 1.81498543411901 0.785714285714286 26.2 26 2 increased effector memory CD4-positive, alpha-beta T cell number 4.29031687778737e-05 0.000811571348554836 1.79665224791579 0.777777777777778 26.2 26 2 abnormal posterior semicircular canal morphology 0.00447997506736423 0.0340136661231006 1.79665224791579 0.777777777777778 26.2 26 2 enlarged otoliths 0.00447997506736423 0.0340136661231006 1.79665224791579 0.777777777777778 26.2 26 2 premature bone ossification 0.00447997506736423 0.0340136661231006 1.79665224791579 0.777777777777778 26.2 26 2 decreased fear-related response 0.00447997506736423 0.0340136661231006 1.79665224791579 0.777777777777778 26.2 26 2 decreased cellular sensitivity to ionizing radiation 0.00447997506736423 0.0340136661231006 1.79665224791579 0.777777777777778 26.2 26 2 increased neuronal precursor cell number 0.00447997506736423 0.0340136661231006 1.79665224791579 0.777777777777778 26.2 26 2 eye opacity 0.00447997506736423 0.0340136661231006 1.79665224791579 0.777777777777778 26.2 26 2 decreased transitional stage T1 B cell number 0.00447997506736423 0.0340136661231006 1.79665224791579 0.777777777777778 26.2 26 2 abnormal hippocampus granule cell morphology 0.00447997506736423 0.0340136661231006 1.79665224791579 0.777777777777778 26.2 26 2 abnormal ureteric bud invasion 0.00447997506736423 0.0340136661231006 1.79665224791579 0.777777777777778 26.2 26 2 abnormal ductus venosus valve topology 0.00447997506736423 0.0340136661231006 1.79665224791579 0.777777777777778 26.2 26 2 symmetric azygos veins 0.00447997506736423 0.0340136661231006 1.79665224791579 0.777777777777778 26.2 26 2 cerebellum atrophy 0.00447997506736423 0.0340136661231006 1.79665224791579 0.777777777777778 26.2 26 2 decreased platelet dense granule number 0.00447997506736423 0.0340136661231006 1.79665224791579 0.777777777777778 26.2 26 2 abnormal object recognition memory 7.92588042722306e-08 3.23207009224875e-06 1.78837274446917 0.774193548387097 26.2 26 2 abnormal tail bud morphology 0.000692342213264075 0.00793641131564233 1.77690881662001 0.769230769230769 26.2 26 2 abnormal retinal inner plexiform layer morphology 0.000692342213264075 0.00793641131564233 1.77690881662001 0.769230769230769 26.2 26 2 abnormal vertebral arch development 0.000692342213264075 0.00793641131564233 1.77690881662001 0.769230769230769 26.2 26 2 abnormal bone marrow cavity morphology 0.000111488046866378 0.00178345026739624 1.76645641181636 0.764705882352941 26.2 26 2 abnormal glutamate-mediated receptor currents 0.000111488046866378 0.00178345026739624 1.76645641181636 0.764705882352941 26.2 26 2 coloboma 0.000111488046866378 0.00178345026739624 1.76645641181636 0.764705882352941 26.2 26 2 increased intestinal adenocarcinoma incidence 0.000285203904553944 0.0037702698162824 1.73248609620451 0.75 26.2 26 2 enlarged pituitary gland 0.0117130607475915 0.0673670256870145 1.73248609620451 0.75 26.2 26 2 dry eyes 0.0117130607475915 0.0673670256870145 1.73248609620451 0.75 26.2 26 2 decreased aerobic running capacity 0.0117130607475915 0.0673670256870145 1.73248609620451 0.75 26.2 26 2 abnormal neuron apoptosis 0.0117130607475915 0.0673670256870145 1.73248609620451 0.75 26.2 26 2 tau protein deposits 0.0117130607475915 0.0673670256870145 1.73248609620451 0.75 26.2 26 2 long femur 0.0117130607475915 0.0673670256870145 1.73248609620451 0.75 26.2 26 2 abnormal kidney epithelium morphology 0.0117130607475915 0.0673670256870145 1.73248609620451 0.75 26.2 26 2 abnormal somite size 0.0117130607475915 0.0673670256870145 1.73248609620451 0.75 26.2 26 2 ocular hypertension 0.0117130607475915 0.0673670256870145 1.73248609620451 0.75 26.2 26 2 craniofacial phenotype 0.0117130607475915 0.0673670256870145 1.73248609620451 0.75 26.2 26 2 abnormal mitotic spindle assembly checkpoint 0.0117130607475915 0.0673670256870145 1.73248609620451 0.75 26.2 26 2 pleural effusion 0.0117130607475915 0.0673670256870145 1.73248609620451 0.75 26.2 26 2 delayed suture closure 0.0117130607475915 0.0673670256870145 1.73248609620451 0.75 26.2 26 2 abnormal visual evoked potential 0.0117130607475915 0.0673670256870145 1.73248609620451 0.75 26.2 26 2 abnormal stomach position or orientation 0.0117130607475915 0.0673670256870145 1.73248609620451 0.75 26.2 26 2 abnormal anterior commissure pars posterior morphology 0.0117130607475915 0.0673670256870145 1.73248609620451 0.75 26.2 26 2 decreased lung compliance 0.0117130607475915 0.0673670256870145 1.73248609620451 0.75 26.2 26 2 increased airway resistance 0.0117130607475915 0.0673670256870145 1.73248609620451 0.75 26.2 26 2 absent ureteric bud 0.0117130607475915 0.0673670256870145 1.73248609620451 0.75 26.2 26 2 impaired neuron differentiation 0.0117130607475915 0.0673670256870145 1.73248609620451 0.75 26.2 26 2 absent hypoglossal canal 0.0117130607475915 0.0673670256870145 1.73248609620451 0.75 26.2 26 2 retropleural edema 0.0117130607475915 0.0673670256870145 1.73248609620451 0.75 26.2 26 2 embryo cyst 0.0117130607475915 0.0673670256870145 1.73248609620451 0.75 26.2 26 2 mesocardia 0.00178500731098215 0.0167239385539288 1.73248609620451 0.75 26.2 26 2 abnormal enteric nervous system morphology 0.00178500731098215 0.0167239385539288 1.73248609620451 0.75 26.2 26 2 abnormal thymus involution 0.00178500731098215 0.0167239385539288 1.73248609620451 0.75 26.2 26 2 abnormal corticospinal tract morphology 0.00178500731098215 0.0167239385539288 1.73248609620451 0.75 26.2 26 2 increased osteosarcoma incidence 0.00178500731098215 0.0167239385539288 1.73248609620451 0.75 26.2 26 2 persistent right dorsal aorta 0.00178500731098215 0.0167239385539288 1.73248609620451 0.75 26.2 26 2 embryonic lethality between implantation and placentation, incomplete penetrance 0.00178500731098215 0.0167239385539288 1.73248609620451 0.75 26.2 26 2 increased B cell derived lymphoma incidence 2.18685014110171e-10 1.67378145415092e-08 1.70938628158845 0.74 26.2 26 2 abnormal cardiovascular development 1.95955276040829e-05 0.000420205818234106 1.70737760205662 0.739130434782609 26.2 26 2 abnormal Wolffian duct morphology 1.95955276040829e-05 0.000420205818234106 1.70737760205662 0.739130434782609 26.2 26 2 absent egg cylinders 0.00071671083724124 0.0080348102687866 1.69398640517774 0.733333333333333 26.2 26 2 delayed intramembranous bone ossification 0.00071671083724124 0.0080348102687866 1.69398640517774 0.733333333333333 26.2 26 2 abnormal cerebral aqueduct morphology 0.00071671083724124 0.0080348102687866 1.69398640517774 0.733333333333333 26.2 26 2 lethality at weaning, incomplete penetrance 1.77064379510974e-08 8.63622831438329e-07 1.6902303377605 0.731707317073171 26.2 26 2 increased neuron apoptosis 3.17929702826475e-15 4.94281334863035e-13 1.68257908931796 0.728395061728395 26.2 26 2 abnormal long bone epiphysis morphology 4.84260774820589e-05 0.000889002713923405 1.67998651753164 0.727272727272727 26.2 26 2 abnormal tail movements 4.84260774820589e-05 0.000889002713923405 1.67998651753164 0.727272727272727 26.2 26 2 abnormal occipital bone morphology 4.84260774820589e-05 0.000889002713923405 1.67998651753164 0.727272727272727 26.2 26 2 embryonic lethality before implantation, incomplete penetrance 4.84260774820589e-05 0.000889002713923405 1.67998651753164 0.727272727272727 26.2 26 2 abnormal dorsal-ventral polarity of the somites 0.00449869192140708 0.0340136661231006 1.67998651753164 0.727272727272727 26.2 26 2 common atrioventricular valve 0.00449869192140708 0.0340136661231006 1.67998651753164 0.727272727272727 26.2 26 2 decreased core body temperature 0.00449869192140708 0.0340136661231006 1.67998651753164 0.727272727272727 26.2 26 2 abnormal brain ependyma motile cilium morphology 0.00449869192140708 0.0340136661231006 1.67998651753164 0.727272727272727 26.2 26 2 abnormal spinal nerve morphology 3.42258848684679e-06 9.51250152070546e-05 1.67274519633539 0.724137931034483 26.2 26 2 right pulmonary isomerism 0.000289808729896487 0.00380421749666233 1.66831994449323 0.722222222222222 26.2 26 2 decreased CNS synapse formation 0.00176467551077986 0.0167239385539288 1.64998675829001 0.714285714285714 26.2 26 2 lysosomal protein accumulation 0.00176467551077986 0.0167239385539288 1.64998675829001 0.714285714285714 26.2 26 2 broad head 0.0296736230716778 0.133116568784127 1.64998675829001 0.714285714285714 26.2 26 2 abnormal oculomotor nerve morphology 0.0296736230716778 0.133116568784127 1.64998675829001 0.714285714285714 26.2 26 2 decreased Schwann cell number 0.0296736230716778 0.133116568784127 1.64998675829001 0.714285714285714 26.2 26 2 skin photosensitivity 0.0296736230716778 0.133116568784127 1.64998675829001 0.714285714285714 26.2 26 2 excessive tearing 0.0296736230716778 0.133116568784127 1.64998675829001 0.714285714285714 26.2 26 2 abnormal circulating alanine transaminase level 0.0296736230716778 0.133116568784127 1.64998675829001 0.714285714285714 26.2 26 2 abnormal gastrulation movements 0.0296736230716778 0.133116568784127 1.64998675829001 0.714285714285714 26.2 26 2 abnormal melanocyte morphology 0.0296736230716778 0.133116568784127 1.64998675829001 0.714285714285714 26.2 26 2 decreased mortality induced by ionizing radiation 0.0296736230716778 0.133116568784127 1.64998675829001 0.714285714285714 26.2 26 2 abnormal ciliary body morphology 0.0296736230716778 0.133116568784127 1.64998675829001 0.714285714285714 26.2 26 2 abnormal talus morphology 0.0296736230716778 0.133116568784127 1.64998675829001 0.714285714285714 26.2 26 2 retinal pigment epithelium atrophy 0.0296736230716778 0.133116568784127 1.64998675829001 0.714285714285714 26.2 26 2 abnormal spinal cord central canal morphology 0.0296736230716778 0.133116568784127 1.64998675829001 0.714285714285714 26.2 26 2 heart hemorrhage 0.0296736230716778 0.133116568784127 1.64998675829001 0.714285714285714 26.2 26 2 enhanced behavioral response to alcohol 0.0296736230716778 0.133116568784127 1.64998675829001 0.714285714285714 26.2 26 2 abnormal retina inner limiting membrane morphology 0.0296736230716778 0.133116568784127 1.64998675829001 0.714285714285714 26.2 26 2 abnormal impulsive behavior control 0.0296736230716778 0.133116568784127 1.64998675829001 0.714285714285714 26.2 26 2 abnormal outer hair cell kinocilium morphology 0.0296736230716778 0.133116568784127 1.64998675829001 0.714285714285714 26.2 26 2 embryonic lethality at implantation, incomplete penetrance 0.0296736230716778 0.133116568784127 1.64998675829001 0.714285714285714 26.2 26 2 dysmyelination 0.0296736230716778 0.133116568784127 1.64998675829001 0.714285714285714 26.2 26 2 decreased collagen level 0.0296736230716778 0.133116568784127 1.64998675829001 0.714285714285714 26.2 26 2 abnormal interatrial septum morphology 0.000702121963004106 0.0079895708744945 1.63057514936895 0.705882352941177 26.2 26 2 abnormal cranial suture morphology 0.000702121963004106 0.0079895708744945 1.63057514936895 0.705882352941177 26.2 26 2 absence seizures 0.000702121963004106 0.0079895708744945 1.63057514936895 0.705882352941177 26.2 26 2 abnormal brain commissure morphology 1.97801567016479e-05 0.000420539656370506 1.62554251001904 0.703703703703704 26.2 26 2 abnormal eye muscle morphology 1.97801567016479e-05 0.000420539656370506 1.62554251001904 0.703703703703704 26.2 26 2 decreased paired-pulse facilitation 0.000282228777699535 0.0037442351174805 1.61698702312421 0.7 26.2 26 2 spleen atrophy 0.000282228777699535 0.0037442351174805 1.61698702312421 0.7 26.2 26 2 abnormal neuron proliferation 0.000282228777699535 0.0037442351174805 1.61698702312421 0.7 26.2 26 2 increased skin tumor incidence 0.000282228777699535 0.0037442351174805 1.61698702312421 0.7 26.2 26 2 absent ductus venosus valve 0.000282228777699535 0.0037442351174805 1.61698702312421 0.7 26.2 26 2 retarded hair growth 0.0110335793683432 0.0667786585857757 1.61698702312421 0.7 26.2 26 2 enlarged testis 0.0110335793683432 0.0667786585857757 1.61698702312421 0.7 26.2 26 2 fused cornea and lens 0.0110335793683432 0.0667786585857757 1.61698702312421 0.7 26.2 26 2 abnormal optic nerve innervation 0.0110335793683432 0.0667786585857757 1.61698702312421 0.7 26.2 26 2 abnormal respiratory mechanics 0.0110335793683432 0.0667786585857757 1.61698702312421 0.7 26.2 26 2 peritoneal inflammation 0.0110335793683432 0.0667786585857757 1.61698702312421 0.7 26.2 26 2 absent seminal vesicle 0.0110335793683432 0.0667786585857757 1.61698702312421 0.7 26.2 26 2 abnormal deltoid tuberosity morphology 0.0110335793683432 0.0667786585857757 1.61698702312421 0.7 26.2 26 2 absent coat pigmentation 0.0110335793683432 0.0667786585857757 1.61698702312421 0.7 26.2 26 2 abnormal corneal endothelium morphology 0.0110335793683432 0.0667786585857757 1.61698702312421 0.7 26.2 26 2 abnormal gonadal fat pad morphology 0.0110335793683432 0.0667786585857757 1.61698702312421 0.7 26.2 26 2 osteosclerosis 0.0110335793683432 0.0667786585857757 1.61698702312421 0.7 26.2 26 2 abnormal hippocampus neuron morphology 0.0110335793683432 0.0667786585857757 1.61698702312421 0.7 26.2 26 2 increased circulating fructosamine level 0.0110335793683432 0.0667786585857757 1.61698702312421 0.7 26.2 26 2 abnormal heart and great artery attachment 0.0110335793683432 0.0667786585857757 1.61698702312421 0.7 26.2 26 2 abnormal inferior vena cava valve morphology 0.0110335793683432 0.0667786585857757 1.61698702312421 0.7 26.2 26 2 thin ventricle myocardium compact layer 0.0110335793683432 0.0667786585857757 1.61698702312421 0.7 26.2 26 2 decreased circulating lactate level 0.0110335793683432 0.0667786585857757 1.61698702312421 0.7 26.2 26 2 abnormal synaptic transmission 8.14720154198118e-06 0.000197718671567592 1.61698702312421 0.7 26.2 26 2 single kidney 3.36557716976359e-06 9.45974373987225e-05 1.60998707930116 0.696969696969697 26.2 26 2 abnormal myelin sheath morphology 4.31447718791145e-08 1.882852983321e-06 1.60694362546505 0.695652173913043 26.2 26 2 abnormal cranial nerve morphology 0.000114324477203147 0.00181252467623775 1.60694362546505 0.695652173913043 26.2 26 2 absent kidney 1.8044928388942e-08 8.71587560533847e-07 1.60284427948172 0.693877551020408 26.2 26 2 increased pituitary adenoma incidence 0.00424350378084783 0.0332463485192409 1.59921793495801 0.692307692307692 26.2 26 2 dystrophic cardiac calcinosis 0.00424350378084783 0.0332463485192409 1.59921793495801 0.692307692307692 26.2 26 2 absent hypoglossal nerve 0.00424350378084783 0.0332463485192409 1.59921793495801 0.692307692307692 26.2 26 2 abnormal lumbar vertebrae morphology 7.84321796638586e-06 0.000193168363281038 1.58811225485413 0.6875 26.2 26 2 disorganized retinal layers 0.00166602608915329 0.0159897218485844 1.58811225485413 0.6875 26.2 26 2 white spotting 0.00166602608915329 0.0159897218485844 1.58811225485413 0.6875 26.2 26 2 impaired somite development 0.00166602608915329 0.0159897218485844 1.58811225485413 0.6875 26.2 26 2 decreased fibroblast apoptosis 0.00166602608915329 0.0159897218485844 1.58811225485413 0.6875 26.2 26 2 abnormal dendritic spine morphology 1.74503214188713e-08 8.59557911474104e-07 1.58528139521981 0.686274509803922 26.2 26 2 delayed sexual maturation 0.000663269229571121 0.00765606593298452 1.58051363162516 0.684210526315789 26.2 26 2 palatal shelves fail to meet at midline 5.5471128096544e-07 1.87733919918576e-05 1.57754831524313 0.682926829268293 26.2 26 2 abnormal lysosome physiology 0.00026672659998981 0.00360195043131896 1.57498736018592 0.681818181818182 26.2 26 2 increased mammary gland tumor incidence 0.00026672659998981 0.00360195043131896 1.57498736018592 0.681818181818182 26.2 26 2 abnormal excitatory postsynaptic currents 7.01345391313756e-12 6.8415555329136e-10 1.56960278801434 0.67948717948718 26.2 26 2 abnormal somite shape 4.40557073534771e-05 0.000827083562579429 1.56748742037551 0.678571428571429 26.2 26 2 subcutaneous edema 4.40557073534771e-05 0.000827083562579429 1.56748742037551 0.678571428571429 26.2 26 2 preaxial polydactyly 1.80438817121716e-05 0.000392001360340845 1.56482615141052 0.67741935483871 26.2 26 2 embryonic lethality between implantation and placentation, complete penetrance 2.18051185622184e-07 8.03558998866937e-06 1.55672663716927 0.673913043478261 26.2 26 2 increased embryonic tissue cell apoptosis 3.3645056698038e-11 2.98900280487034e-09 1.53998764107067 0.666666666666667 26.2 26 2 decreased brown adipose tissue amount 1.67984995596303e-05 0.000369789979244075 1.53998764107067 0.666666666666667 26.2 26 2 abnormal locomotor coordination 1.67984995596303e-05 0.000369789979244075 1.53998764107067 0.666666666666667 26.2 26 2 delayed eyelid opening 4.09400530121572e-05 0.000783372168213392 1.53998764107067 0.666666666666667 26.2 26 2 abnormal optic cup morphology 4.09400530121572e-05 0.000783372168213392 1.53998764107067 0.666666666666667 26.2 26 2 absent incisors 0.00386060485785708 0.0311708643263416 1.53998764107067 0.666666666666667 26.2 26 2 abnormal aorta wall morphology 0.00386060485785708 0.0311708643263416 1.53998764107067 0.666666666666667 26.2 26 2 abnormal lysosome morphology 6.91745816048812e-06 0.000172071771742142 1.53998764107067 0.666666666666667 26.2 26 2 abnormal skin appearance 0.000100209082558852 0.00162921629323624 1.53998764107067 0.666666666666667 26.2 26 2 increased hemangiosarcoma incidence 0.000246594603695619 0.00341353903860661 1.53998764107067 0.666666666666667 26.2 26 2 left pulmonary isomerism 0.000610915663811376 0.00720326778640478 1.53998764107067 0.666666666666667 26.2 26 2 abnormal stapes morphology 0.000610915663811376 0.00720326778640478 1.53998764107067 0.666666666666667 26.2 26 2 abnormal mitral valve morphology 0.00152674842921935 0.0150110146943997 1.53998764107067 0.666666666666667 26.2 26 2 eye inflammation 0.00152674842921935 0.0150110146943997 1.53998764107067 0.666666666666667 26.2 26 2 abnormal bile duct morphology 0.00152674842921935 0.0150110146943997 1.53998764107067 0.666666666666667 26.2 26 2 abnormal anterior eye segment morphology 0.00152674842921935 0.0150110146943997 1.53998764107067 0.666666666666667 26.2 26 2 increased effector memory CD8-positive, alpha-beta T cell number 0.00152674842921935 0.0150110146943997 1.53998764107067 0.666666666666667 26.2 26 2 abnormal hypoglossal nerve topology 0.00152674842921935 0.0150110146943997 1.53998764107067 0.666666666666667 26.2 26 2 abnormal supraoccipital bone morphology 0.00992606114225691 0.0621941488447458 1.53998764107067 0.666666666666667 26.2 26 2 myocarditis 0.00992606114225691 0.0621941488447458 1.53998764107067 0.666666666666667 26.2 26 2 increased papilloma incidence 0.00992606114225691 0.0621941488447458 1.53998764107067 0.666666666666667 26.2 26 2 decreased synaptic depression 0.00992606114225691 0.0621941488447458 1.53998764107067 0.666666666666667 26.2 26 2 dilated bile duct 0.00992606114225691 0.0621941488447458 1.53998764107067 0.666666666666667 26.2 26 2 absent ovary 0.00992606114225691 0.0621941488447458 1.53998764107067 0.666666666666667 26.2 26 2 pale placenta 0.00992606114225691 0.0621941488447458 1.53998764107067 0.666666666666667 26.2 26 2 abnormal fatty acid level 0.00992606114225691 0.0621941488447458 1.53998764107067 0.666666666666667 26.2 26 2 abnormal vitelline vein connection 0.00992606114225691 0.0621941488447458 1.53998764107067 0.666666666666667 26.2 26 2 abnormal sympathetic neuron morphology 0.026179232108046 0.126765307330344 1.53998764107067 0.666666666666667 26.2 26 2 absent enteric neurons 0.026179232108046 0.126765307330344 1.53998764107067 0.666666666666667 26.2 26 2 abnormal kindling response 0.026179232108046 0.126765307330344 1.53998764107067 0.666666666666667 26.2 26 2 abnormal NMDA-mediated synaptic currents 0.026179232108046 0.126765307330344 1.53998764107067 0.666666666666667 26.2 26 2 decreased circulating bicarbonate level 0.026179232108046 0.126765307330344 1.53998764107067 0.666666666666667 26.2 26 2 pancreas cysts 0.026179232108046 0.126765307330344 1.53998764107067 0.666666666666667 26.2 26 2 abnormal proprioceptive neuron morphology 0.026179232108046 0.126765307330344 1.53998764107067 0.666666666666667 26.2 26 2 small scapula 0.026179232108046 0.126765307330344 1.53998764107067 0.666666666666667 26.2 26 2 abnormal CNS synapse formation 0.026179232108046 0.126765307330344 1.53998764107067 0.666666666666667 26.2 26 2 abnormal posterior eye segment morphology 0.026179232108046 0.126765307330344 1.53998764107067 0.666666666666667 26.2 26 2 abnormal intervertebral disk development 0.026179232108046 0.126765307330344 1.53998764107067 0.666666666666667 26.2 26 2 enhanced conditioned place preference behavior 0.026179232108046 0.126765307330344 1.53998764107067 0.666666666666667 26.2 26 2 abnormal optic chiasm morphology 0.026179232108046 0.126765307330344 1.53998764107067 0.666666666666667 26.2 26 2 iris coloboma 0.026179232108046 0.126765307330344 1.53998764107067 0.666666666666667 26.2 26 2 decreased bone trabecular spacing 0.026179232108046 0.126765307330344 1.53998764107067 0.666666666666667 26.2 26 2 abnormal infrahyoid muscle connection 0.026179232108046 0.126765307330344 1.53998764107067 0.666666666666667 26.2 26 2 increased cardiac muscle glycogen level 0.026179232108046 0.126765307330344 1.53998764107067 0.666666666666667 26.2 26 2 atrioventricular septal defect 7.89338024458649e-08 3.23207009224875e-06 1.52545945577755 0.660377358490566 26.2 26 2 persistence of hyaloid vascular system 6.37282158272055e-06 0.000162588653200178 1.51972464579343 0.657894736842105 26.2 26 2 impaired branching involved in ureteric bud morphogenesis 6.37282158272055e-06 0.000162588653200178 1.51972464579343 0.657894736842105 26.2 26 2 abnormal axon morphology 2.68889175373713e-14 3.82206756424063e-12 1.51859892383358 0.657407407407407 26.2 26 2 pancreatic islet hyperplasia 3.75178761359442e-05 0.000726270170335885 1.51592533417894 0.65625 26.2 26 2 abnormal embryonic erythropoiesis 9.15130624642075e-05 0.00153809961405214 1.51343613001773 0.655172413793103 26.2 26 2 decreased cell proliferation 4.88717125965521e-23 1.62091180111898e-20 1.51085273975312 0.654054054054054 26.2 26 2 no spontaneous movement 0.000224227258173694 0.00314233974482852 1.51037249412701 0.653846153846154 26.2 26 2 decreased circulating glycerol level 0.000224227258173694 0.00314233974482852 1.51037249412701 0.653846153846154 26.2 26 2 abnormal Mullerian duct morphology 0.000224227258173694 0.00314233974482852 1.51037249412701 0.653846153846154 26.2 26 2 abnormal cell cycle 9.68975526775705e-15 1.46080401385125e-12 1.50650964887349 0.652173913043478 26.2 26 2 failure to gastrulate 1.00266109256019e-06 3.15711325030819e-05 1.50650964887349 0.652173913043478 26.2 26 2 abnormal coat/hair pigmentation 2.29417124427023e-14 3.356912335366e-12 1.50561291693963 0.651785714285714 26.2 26 2 increased mammary adenocarcinoma incidence 0.00137091578304692 0.0137506169771339 1.50148795004391 0.65 26.2 26 2 abnormal hearing physiology 0.00137091578304692 0.0137506169771339 1.50148795004391 0.65 26.2 26 2 decreased myocardial infarction size 0.00137091578304692 0.0137506169771339 1.50148795004391 0.65 26.2 26 2 abnormal incus morphology 0.00137091578304692 0.0137506169771339 1.50148795004391 0.65 26.2 26 2 abnormal response to novel object 3.80534948466039e-07 1.34266763731812e-05 1.49469388692154 0.647058823529412 26.2 26 2 abnormal oocyte morphology 3.39940353939811e-05 0.000671112405099428 1.49469388692154 0.647058823529412 26.2 26 2 impaired synaptic plasticity 3.39940353939811e-05 0.000671112405099428 1.49469388692154 0.647058823529412 26.2 26 2 abnormal brown adipose tissue morphology 3.39940353939811e-05 0.000671112405099428 1.49469388692154 0.647058823529412 26.2 26 2 hyperlipidemia 0.00343318365376013 0.0285143383596939 1.49469388692154 0.647058823529412 26.2 26 2 abnormal dorsal-ventral axis patterning 0.00343318365376013 0.0285143383596939 1.49469388692154 0.647058823529412 26.2 26 2 enhanced behavioral response to cocaine 0.00343318365376013 0.0285143383596939 1.49469388692154 0.647058823529412 26.2 26 2 abnormal survival 0.00343318365376013 0.0285143383596939 1.49469388692154 0.647058823529412 26.2 26 2 increased trabecular bone mass 0.00343318365376013 0.0285143383596939 1.49469388692154 0.647058823529412 26.2 26 2 pale kidney 8.25694553757681e-05 0.00139722122617159 1.49031062039097 0.645161290322581 26.2 26 2 hypoxia 0.000201285157928526 0.00291951504575632 1.48498808246101 0.642857142857143 26.2 26 2 increased triglyceride level 0.000201285157928526 0.00291951504575632 1.48498808246101 0.642857142857143 26.2 26 2 midline facial cleft 0.00870539466697018 0.05581100318064 1.48498808246101 0.642857142857143 26.2 26 2 amyloid beta deposits 0.00870539466697018 0.05581100318064 1.48498808246101 0.642857142857143 26.2 26 2 abnormal renal tubule epithelial cell primary cilium morphology 0.00870539466697018 0.05581100318064 1.48498808246101 0.642857142857143 26.2 26 2 enlarged kidney 3.44508279411954e-07 1.22423477862462e-05 1.4818748998982 0.641509433962264 26.2 26 2 abnormal vertebrae development 0.000492843341842902 0.0060540632732554 1.47838813542785 0.64 26.2 26 2 reduced long term depression 3.05145804679811e-05 0.000614615537766017 1.4758214893594 0.638888888888889 26.2 26 2 renal hypoplasia 3.05145804679811e-05 0.000614615537766017 1.4758214893594 0.638888888888889 26.2 26 2 abnormal cell nucleus morphology 1.96961270378696e-06 5.90290554297599e-05 1.47445625208894 0.638297872340426 26.2 26 2 abnormal CNS synaptic transmission 6.54338615810395e-12 6.78194711178482e-10 1.46998820284019 0.636363636363636 26.2 26 2 belly spot 7.37767851444931e-05 0.00127444272949255 1.46998820284019 0.636363636363636 26.2 26 2 testis hypoplasia 0.00121324652549911 0.0126804652612565 1.46998820284019 0.636363636363636 26.2 26 2 abnormal channel response 0.00121324652549911 0.0126804652612565 1.46998820284019 0.636363636363636 26.2 26 2 cleft upper lip 0.00121324652549911 0.0126804652612565 1.46998820284019 0.636363636363636 26.2 26 2 abnormal sperm midpiece morphology 0.00121324652549911 0.0126804652612565 1.46998820284019 0.636363636363636 26.2 26 2 decreased atrioventricular cushion size 0.0224696324004816 0.113373652324945 1.46998820284019 0.636363636363636 26.2 26 2 enlarged cranium 0.0224696324004816 0.113373652324945 1.46998820284019 0.636363636363636 26.2 26 2 abnormal enteric ganglia morphology 0.0224696324004816 0.113373652324945 1.46998820284019 0.636363636363636 26.2 26 2 abnormal proximal-distal axis patterning 0.0224696324004816 0.113373652324945 1.46998820284019 0.636363636363636 26.2 26 2 decreased post-tetanic potentiation 0.0224696324004816 0.113373652324945 1.46998820284019 0.636363636363636 26.2 26 2 fused joints 0.0224696324004816 0.113373652324945 1.46998820284019 0.636363636363636 26.2 26 2 increased circulating triiodothyronine level 0.0224696324004816 0.113373652324945 1.46998820284019 0.636363636363636 26.2 26 2 aorta dilation 0.0224696324004816 0.113373652324945 1.46998820284019 0.636363636363636 26.2 26 2 abnormal extraembryonic ectoderm morphology 0.0224696324004816 0.113373652324945 1.46998820284019 0.636363636363636 26.2 26 2 hypolactation 0.0224696324004816 0.113373652324945 1.46998820284019 0.636363636363636 26.2 26 2 reduced sympathetic cervical ganglion size 0.0224696324004816 0.113373652324945 1.46998820284019 0.636363636363636 26.2 26 2 gliosis 4.92056563925003e-08 2.09229179959563e-06 1.46665489625778 0.634920634920635 26.2 26 2 abnormal placenta vasculature 7.39010824664187e-07 2.38738886539242e-05 1.46594977371151 0.634615384615385 26.2 26 2 Leydig cell hyperplasia 1.13147907708023e-05 0.000260606870762691 1.46486629272576 0.634146341463415 26.2 26 2 disorganized myocardium 0.000178866442426841 0.00265630015245832 1.46298825901714 0.633333333333333 26.2 26 2 enhanced paired-pulse facilitation 0.000178866442426841 0.00265630015245832 1.46298825901714 0.633333333333333 26.2 26 2 abnormal brain vasculature morphology 0.000178866442426841 0.00265630015245832 1.46298825901714 0.633333333333333 26.2 26 2 ventricular septal defect 1.74557092821043e-15 2.80135979607964e-13 1.46072357130968 0.632352941176471 26.2 26 2 irregular coat pigmentation 0.00300699848575916 0.0258373358664108 1.45893565996169 0.631578947368421 26.2 26 2 abnormal stationary movement 0.00300699848575916 0.0258373358664108 1.45893565996169 0.631578947368421 26.2 26 2 abnormal long term depression 0.00300699848575916 0.0258373358664108 1.45893565996169 0.631578947368421 26.2 26 2 abnormal neuronal precursor proliferation 6.59826123765141e-07 2.15962826692867e-05 1.4544327721223 0.62962962962963 26.2 26 2 abnormal trigeminal nerve morphology 0.000435058156718925 0.00543822695898656 1.4544327721223 0.62962962962963 26.2 26 2 increased brain weight 0.000435058156718925 0.00543822695898656 1.4544327721223 0.62962962962963 26.2 26 2 embryonic lethality between somite formation and embryo turning, complete penetrance 1.66309162774973e-08 8.27388084805491e-07 1.45198834729521 0.628571428571429 26.2 26 2 impaired adaptive thermogenesis 6.53954716952278e-05 0.00115432132679251 1.45198834729521 0.628571428571429 26.2 26 2 abnormal axon guidance 1.00546272784306e-05 0.000238198908143773 1.45045347589215 0.627906976744186 26.2 26 2 pale yolk sac 1.00797229184489e-09 6.86940020812097e-08 1.44721730124714 0.626506024096386 26.2 26 2 double outlet right ventricle 4.2421593308822e-12 4.68994281580866e-10 1.4464369899776 0.626168224299065 26.2 26 2 lethality throughout fetal growth and development, incomplete penetrance 3.38118327477246e-19 8.01018418666334e-17 1.44535152904957 0.625698324022346 26.2 26 2 abnormal vertebral body morphology 0.000157655420775474 0.00238399914394523 1.44373841350376 0.625 26.2 26 2 abnormal embryonic hematopoiesis 0.000157655420775474 0.00238399914394523 1.44373841350376 0.625 26.2 26 2 abnormal auditory brainstem response waveform shape 0.000157655420775474 0.00238399914394523 1.44373841350376 0.625 26.2 26 2 increased fibroblast apoptosis 0.000157655420775474 0.00238399914394523 1.44373841350376 0.625 26.2 26 2 disorganized yolk sac vascular plexus 0.00751823613903008 0.0516619126956832 1.44373841350376 0.625 26.2 26 2 abnormal epicardium morphology 0.00751823613903008 0.0516619126956832 1.44373841350376 0.625 26.2 26 2 dystonia 0.00751823613903008 0.0516619126956832 1.44373841350376 0.625 26.2 26 2 clubfoot 0.0596078936118218 0.226893091598174 1.44373841350376 0.625 26.2 26 2 increased sensitivity to skin irradiation 0.0596078936118218 0.226893091598174 1.44373841350376 0.625 26.2 26 2 abnormal urination 0.0596078936118218 0.226893091598174 1.44373841350376 0.625 26.2 26 2 abnormal cellular cholesterol metabolism 0.0596078936118218 0.226893091598174 1.44373841350376 0.625 26.2 26 2 decreased susceptibility to age related obesity 0.0596078936118218 0.226893091598174 1.44373841350376 0.625 26.2 26 2 liver cysts 0.0596078936118218 0.226893091598174 1.44373841350376 0.625 26.2 26 2 increased cardiac output 0.0596078936118218 0.226893091598174 1.44373841350376 0.625 26.2 26 2 abnormal eyelid aperture 0.0596078936118218 0.226893091598174 1.44373841350376 0.625 26.2 26 2 thin stria vascularis 0.0596078936118218 0.226893091598174 1.44373841350376 0.625 26.2 26 2 absent cochlear microphonics 0.0596078936118218 0.226893091598174 1.44373841350376 0.625 26.2 26 2 accumulation of giant lysosomes in kidney/renal tubule cells 0.0596078936118218 0.226893091598174 1.44373841350376 0.625 26.2 26 2 non-pigmented tail tip 0.0596078936118218 0.226893091598174 1.44373841350376 0.625 26.2 26 2 Sertoli cell hypoplasia 0.0596078936118218 0.226893091598174 1.44373841350376 0.625 26.2 26 2 abnormal epidermal lamellar body morphology 0.0596078936118218 0.226893091598174 1.44373841350376 0.625 26.2 26 2 abnormal base-excision repair 0.0596078936118218 0.226893091598174 1.44373841350376 0.625 26.2 26 2 abnormal olfactory bulb mitral cell layer morphology 0.0596078936118218 0.226893091598174 1.44373841350376 0.625 26.2 26 2 abnormal cerebellum deep nucleus morphology 0.0596078936118218 0.226893091598174 1.44373841350376 0.625 26.2 26 2 abnormal brain ependyma morphology 0.0596078936118218 0.226893091598174 1.44373841350376 0.625 26.2 26 2 abnormal hepatic vein morphology 0.0596078936118218 0.226893091598174 1.44373841350376 0.625 26.2 26 2 pulmonary artery hypoplasia 0.0596078936118218 0.226893091598174 1.44373841350376 0.625 26.2 26 2 myocardial trabeculae hypoplasia 0.0596078936118218 0.226893091598174 1.44373841350376 0.625 26.2 26 2 lung situs inversus 0.0596078936118218 0.226893091598174 1.44373841350376 0.625 26.2 26 2 abnormal bronchiole epithelium morphology 0.0596078936118218 0.226893091598174 1.44373841350376 0.625 26.2 26 2 increased aorta wall thickness 0.0596078936118218 0.226893091598174 1.44373841350376 0.625 26.2 26 2 prolonged PQ interval 0.0596078936118218 0.226893091598174 1.44373841350376 0.625 26.2 26 2 increased testis apoptosis 0.0596078936118218 0.226893091598174 1.44373841350376 0.625 26.2 26 2 increased mammary gland apoptosis 0.0596078936118218 0.226893091598174 1.44373841350376 0.625 26.2 26 2 decreased white adipose tissue mass 0.0596078936118218 0.226893091598174 1.44373841350376 0.625 26.2 26 2 vertebral transformation 3.73281920125484e-06 0.000100928127860015 1.44373841350376 0.625 26.2 26 2 abnormal nursing 0.00106229054108011 0.0113653665416636 1.44373841350376 0.625 26.2 26 2 abnormal startle reflex 0.00106229054108011 0.0113653665416636 1.44373841350376 0.625 26.2 26 2 abnormal sensory capabilities/reflexes/nociception 0.00106229054108011 0.0113653665416636 1.44373841350376 0.625 26.2 26 2 abnormal retinal ganglion layer morphology 0.00106229054108011 0.0113653665416636 1.44373841350376 0.625 26.2 26 2 lethality at weaning, complete penetrance 8.88529548507817e-06 0.000213547560571323 1.43732179833263 0.622222222222222 26.2 26 2 absent long term depression 0.000380912223233776 0.00484664529562157 1.4337815968589 0.620689655172414 26.2 26 2 blood in lymph vessels 0.000380912223233776 0.00484664529562157 1.4337815968589 0.620689655172414 26.2 26 2 abnormal embryo size 2.98661574213594e-12 3.37691211752871e-10 1.43096196736656 0.619469026548673 26.2 26 2 abnormal optic nerve morphology 2.1160979067167e-05 0.000447982429187897 1.42998852385134 0.619047619047619 26.2 26 2 abnormal scapula morphology 0.00260591597680468 0.0230274102746062 1.42998852385134 0.619047619047619 26.2 26 2 abnormal embryonic/fetal subventricular zone morphology 0.00260591597680468 0.0230274102746062 1.42998852385134 0.619047619047619 26.2 26 2 increased muscle cell glucose uptake 0.00260591597680468 0.0230274102746062 1.42998852385134 0.619047619047619 26.2 26 2 abnormal nervous system development 0.000138041227049167 0.0021664198882322 1.42675325569783 0.617647058823529 26.2 26 2 kinked neural tube 2.89700963557673e-06 8.28311663045645e-05 1.42152705329601 0.615384615384615 26.2 26 2 absent teeth 0.0190181529205115 0.0998051801471988 1.42152705329601 0.615384615384615 26.2 26 2 absent common myeloid progenitor cells 0.0190181529205115 0.0998051801471988 1.42152705329601 0.615384615384615 26.2 26 2 absent trabeculae carneae 0.0190181529205115 0.0998051801471988 1.42152705329601 0.615384615384615 26.2 26 2 increased foot pad pigmentation 0.0190181529205115 0.0998051801471988 1.42152705329601 0.615384615384615 26.2 26 2 abnormal sympathetic ganglion morphology 0.0190181529205115 0.0998051801471988 1.42152705329601 0.615384615384615 26.2 26 2 lymphoid hypoplasia 0.0190181529205115 0.0998051801471988 1.42152705329601 0.615384615384615 26.2 26 2 abnormal otolith morphology 0.0190181529205115 0.0998051801471988 1.42152705329601 0.615384615384615 26.2 26 2 axonal dystrophy 0.0190181529205115 0.0998051801471988 1.42152705329601 0.615384615384615 26.2 26 2 decreased luteinizing hormone level 0.0190181529205115 0.0998051801471988 1.42152705329601 0.615384615384615 26.2 26 2 orthokeratosis 0.0190181529205115 0.0998051801471988 1.42152705329601 0.615384615384615 26.2 26 2 empty decidua capsularis 0.0190181529205115 0.0998051801471988 1.42152705329601 0.615384615384615 26.2 26 2 abnormal brain morphology 2.09681227606755e-16 3.59711761152967e-14 1.42042338322357 0.614906832298137 26.2 26 2 abnormal craniofacial bone morphology 1.07751498231418e-06 3.37146983459941e-05 1.4184096694072 0.614035087719298 26.2 26 2 abnormal podocyte morphology 0.000331336671924375 0.00431518309639729 1.41579508937143 0.612903225806452 26.2 26 2 increased T cell derived lymphoma incidence 6.84352085202555e-06 0.000171088021300639 1.41427436424858 0.612244897959184 26.2 26 2 abnormal cochlea morphology 2.5372618680758e-06 7.33888243818436e-05 1.41165533764812 0.611111111111111 26.2 26 2 increased cell proliferation 2.5372618680758e-06 7.33888243818436e-05 1.41165533764812 0.611111111111111 26.2 26 2 underdeveloped hair follicles 0.00642901043518135 0.0454969088407215 1.41165533764812 0.611111111111111 26.2 26 2 cortical renal glomerulopathies 0.00642901043518135 0.0454969088407215 1.41165533764812 0.611111111111111 26.2 26 2 abnormal thyroid cartilage morphology 0.00642901043518135 0.0454969088407215 1.41165533764812 0.611111111111111 26.2 26 2 abnormal thymus cortex morphology 0.00642901043518135 0.0454969088407215 1.41165533764812 0.611111111111111 26.2 26 2 absent inner cell mass 0.00642901043518135 0.0454969088407215 1.41165533764812 0.611111111111111 26.2 26 2 decreased lactate dehydrogenase level 0.00642901043518135 0.0454969088407215 1.41165533764812 0.611111111111111 26.2 26 2 increased gastrointestinal tumor incidence 0.00642901043518135 0.0454969088407215 1.41165533764812 0.611111111111111 26.2 26 2 decreased tumor latency 0.00642901043518135 0.0454969088407215 1.41165533764812 0.611111111111111 26.2 26 2 abnormal aerobic respiration 0.00642901043518135 0.0454969088407215 1.41165533764812 0.611111111111111 26.2 26 2 abnormal metanephric mesenchyme morphology 0.00642901043518135 0.0454969088407215 1.41165533764812 0.611111111111111 26.2 26 2 abnormal allantois morphology 1.6161115394727e-05 0.000362169140039491 1.40607567228192 0.608695652173913 26.2 26 2 atrial septal defect 1.6161115394727e-05 0.000362169140039491 1.40607567228192 0.608695652173913 26.2 26 2 abnormal innervation pattern to muscle 0.00224110466260805 0.0202718103572273 1.40607567228192 0.608695652173913 26.2 26 2 abnormal sacral vertebrae morphology 0.00224110466260805 0.0202718103572273 1.40607567228192 0.608695652173913 26.2 26 2 abnormal brainstem morphology 0.000796343700304086 0.00884332568976078 1.40248874454651 0.607142857142857 26.2 26 2 dextrocardia 0.000286699475592366 0.00377335950019053 1.3999887646097 0.606060606060606 26.2 26 2 seizures 1.99510984362228e-11 1.83808730963349e-09 1.39814667412995 0.605263157894737 26.2 26 2 decreased birth body size 1.99510984362228e-11 1.83808730963349e-09 1.39814667412995 0.605263157894737 26.2 26 2 increased tumor incidence 2.85154329764472e-12 3.29916928041453e-10 1.39716620661654 0.604838709677419 26.2 26 2 abnormal neural tube closure 1.40917741295497e-08 7.22748209221748e-07 1.39155509735302 0.602409638554217 26.2 26 2 abnormal cell proliferation 0.00546112253982751 0.0403102145929405 1.38598887696361 0.6 26.2 26 2 abnormal circulating enzyme level 0.00546112253982751 0.0403102145929405 1.38598887696361 0.6 26.2 26 2 anencephaly 0.00546112253982751 0.0403102145929405 1.38598887696361 0.6 26.2 26 2 decreased muscle cell glucose uptake 0.00546112253982751 0.0403102145929405 1.38598887696361 0.6 26.2 26 2 abnormal lateral semicircular canal morphology 0.0488977112176001 0.196182349441581 1.38598887696361 0.6 26.2 26 2 abnormal mammary gland physiology 0.0488977112176001 0.196182349441581 1.38598887696361 0.6 26.2 26 2 abnormal scala media morphology 0.0488977112176001 0.196182349441581 1.38598887696361 0.6 26.2 26 2 intestinal hypoperistalsis 0.0488977112176001 0.196182349441581 1.38598887696361 0.6 26.2 26 2 abnormal glial cell physiology 0.0488977112176001 0.196182349441581 1.38598887696361 0.6 26.2 26 2 abnormal hindlimb zeugopod morphology 0.0488977112176001 0.196182349441581 1.38598887696361 0.6 26.2 26 2 abnormal reproductive system development 0.0488977112176001 0.196182349441581 1.38598887696361 0.6 26.2 26 2 abnormal embryonic erythrocyte morphology 0.0488977112176001 0.196182349441581 1.38598887696361 0.6 26.2 26 2 increased platelet aggregation 0.0488977112176001 0.196182349441581 1.38598887696361 0.6 26.2 26 2 abnormal spinal cord dorsal column morphology 0.0488977112176001 0.196182349441581 1.38598887696361 0.6 26.2 26 2 abnormal sperm principal piece morphology 0.0488977112176001 0.196182349441581 1.38598887696361 0.6 26.2 26 2 common ventricle 0.0488977112176001 0.196182349441581 1.38598887696361 0.6 26.2 26 2 fusion of atlas and odontoid process 0.0488977112176001 0.196182349441581 1.38598887696361 0.6 26.2 26 2 abnormal adaptive thermogenesis 0.0488977112176001 0.196182349441581 1.38598887696361 0.6 26.2 26 2 lethality during fetal growth through weaning, complete penetrance 0.0488977112176001 0.196182349441581 1.38598887696361 0.6 26.2 26 2 decreased circulating total protein level 4.50399637188108e-06 0.000119825571925713 1.38598887696361 0.6 26.2 26 2 abnormal axon extension 1.21656627771636e-05 0.000278913236481054 1.38598887696361 0.6 26.2 26 2 abnormal hippocampus pyramidal cell morphology 0.000247009860080077 0.00341353903860661 1.38598887696361 0.6 26.2 26 2 interdigital webbing 0.0159725793806398 0.0867506358282566 1.38598887696361 0.6 26.2 26 2 decreased hepatocyte number 0.0159725793806398 0.0867506358282566 1.38598887696361 0.6 26.2 26 2 abnormal enteric neuron morphology 0.0159725793806398 0.0867506358282566 1.38598887696361 0.6 26.2 26 2 no suckling reflex 0.0159725793806398 0.0867506358282566 1.38598887696361 0.6 26.2 26 2 increased alcohol consumption 0.0159725793806398 0.0867506358282566 1.38598887696361 0.6 26.2 26 2 dilated ureter 0.0159725793806398 0.0867506358282566 1.38598887696361 0.6 26.2 26 2 abnormal zygomatic bone morphology 0.0159725793806398 0.0867506358282566 1.38598887696361 0.6 26.2 26 2 immune system phenotype 0.0159725793806398 0.0867506358282566 1.38598887696361 0.6 26.2 26 2 decreased thymocyte apoptosis 0.0159725793806398 0.0867506358282566 1.38598887696361 0.6 26.2 26 2 bicuspid aortic valve 0.0159725793806398 0.0867506358282566 1.38598887696361 0.6 26.2 26 2 herniated liver 0.0159725793806398 0.0867506358282566 1.38598887696361 0.6 26.2 26 2 decreased brown adipose tissue mass 0.0159725793806398 0.0867506358282566 1.38598887696361 0.6 26.2 26 2 ataxia 2.07940516271526e-18 4.7022912202311e-16 1.38370176660558 0.599009900990099 26.2 26 2 abnormal eye morphology 5.44878818541769e-13 6.77693030561325e-11 1.37934144829711 0.597122302158273 26.2 26 2 rib fusion 5.40361815639307e-07 1.84130139233257e-05 1.37909340991404 0.597014925373134 26.2 26 2 abnormal brain wave pattern 1.05097135470138e-05 0.000245812567097934 1.37710433288051 0.596153846153846 26.2 26 2 embryonic lethality between implantation and somite formation, complete penetrance 1.34212953431182e-21 3.70949690733406e-19 1.37656038120195 0.595918367346939 26.2 26 2 scoliosis 0.00058517850052661 0.00703580546155089 1.37155149282857 0.59375 26.2 26 2 kidney cortex cysts 0.00058517850052661 0.00703580546155089 1.37155149282857 0.59375 26.2 26 2 small spleen 8.00949611560331e-09 4.33122208425288e-07 1.37075822996401 0.593406593406593 26.2 26 2 abnormal thoracic vertebrae morphology 3.36250461458568e-06 9.45974373987225e-05 1.37032798569848 0.593220338983051 26.2 26 2 abnormal heart valve morphology 0.00163182313970595 0.0159495483694246 1.36887790317393 0.592592592592593 26.2 26 2 abnormal atrioventricular cushion morphology 0.00163182313970595 0.0159495483694246 1.36887790317393 0.592592592592593 26.2 26 2 decreased embryo size 8.15695963776416e-40 6.76347903297945e-37 1.36762500760356 0.592050209205021 26.2 26 2 intracerebral hemorrhage 0.00461754962869047 0.0346490337899474 1.36498904549446 0.590909090909091 26.2 26 2 abnormal vascular branching morphogenesis 0.00461754962869047 0.0346490337899474 1.36498904549446 0.590909090909091 26.2 26 2 abnormal limb posture 0.00461754962869047 0.0346490337899474 1.36498904549446 0.590909090909091 26.2 26 2 abnormal cerebral cortex pyramidal cell morphology 0.00461754962869047 0.0346490337899474 1.36498904549446 0.590909090909091 26.2 26 2 increased circulating creatine kinase level 0.00461754962869047 0.0346490337899474 1.36498904549446 0.590909090909091 26.2 26 2 small liver 1.30398265107255e-07 5.14866165800471e-06 1.36229675940867 0.58974358974359 26.2 26 2 failure of heart looping 0.000181512857593247 0.00267960375823859 1.36229675940867 0.58974358974359 26.2 26 2 abnormal response to injury 0.000181512857593247 0.00267960375823859 1.36229675940867 0.58974358974359 26.2 26 2 embryonic lethality, complete penetrance 1.4692922435716e-26 6.09144075980727e-24 1.36136838489633 0.589341692789969 26.2 26 2 impaired balance 1.94772144531299e-09 1.24229669108104e-07 1.35881262447412 0.588235294117647 26.2 26 2 abnormal direction of heart looping 0.000499068402082652 0.00607057530650659 1.35881262447412 0.588235294117647 26.2 26 2 abnormal adipose tissue morphology 0.0133540254037015 0.0751541588047679 1.35881262447412 0.588235294117647 26.2 26 2 increased incidence of corneal inflammation 0.0133540254037015 0.0751541588047679 1.35881262447412 0.588235294117647 26.2 26 2 abnormal touch/ nociception 0.0133540254037015 0.0751541588047679 1.35881262447412 0.588235294117647 26.2 26 2 abnormal embryonic-extraembryonic boundary morphology 0.0133540254037015 0.0751541588047679 1.35881262447412 0.588235294117647 26.2 26 2 abnormal tarsal bone morphology 0.0133540254037015 0.0751541588047679 1.35881262447412 0.588235294117647 26.2 26 2 abnormal ductus venosus valve morphology 0.0133540254037015 0.0751541588047679 1.35881262447412 0.588235294117647 26.2 26 2 abnormal cell cytoskeleton morphology 0.0133540254037015 0.0751541588047679 1.35881262447412 0.588235294117647 26.2 26 2 abnormal cell death 5.69282291211473e-05 0.00102615195607865 1.35585868398614 0.58695652173913 26.2 26 2 increased mortality induced by gamma-irradiation 0.00138487162615369 0.013834811927941 1.35412706370007 0.586206896551724 26.2 26 2 increased bone trabecula number 0.000154979013363719 0.00238297896076008 1.3521842702084 0.585365853658537 26.2 26 2 anophthalmia 3.12770870448306e-08 1.44077322266697e-06 1.34965208992711 0.584269662921348 26.2 26 2 preweaning lethality, complete penetrance 6.76297166262538e-58 1.68228920107806e-54 1.34852971812675 0.583783783783784 26.2 26 2 intracranial hemorrhage 5.7274362975837e-06 0.000148406226981661 1.34748918593684 0.583333333333333 26.2 26 2 decreased body height 0.00389144443274715 0.0311708643263416 1.34748918593684 0.583333333333333 26.2 26 2 increased stereotypic behavior 0.00389144443274715 0.0311708643263416 1.34748918593684 0.583333333333333 26.2 26 2 abnormal mating frequency 0.040030632161996 0.166515380439741 1.34748918593684 0.583333333333333 26.2 26 2 interstitial pneumonia 0.040030632161996 0.166515380439741 1.34748918593684 0.583333333333333 26.2 26 2 altered tumor susceptibility 0.040030632161996 0.166515380439741 1.34748918593684 0.583333333333333 26.2 26 2 abnormal defecation 0.040030632161996 0.166515380439741 1.34748918593684 0.583333333333333 26.2 26 2 decreased cochlear nerve compound action potential 0.040030632161996 0.166515380439741 1.34748918593684 0.583333333333333 26.2 26 2 abnormal patella morphology 0.040030632161996 0.166515380439741 1.34748918593684 0.583333333333333 26.2 26 2 abnormal thymus corticomedullary boundary morphology 0.040030632161996 0.166515380439741 1.34748918593684 0.583333333333333 26.2 26 2 decreased mammary gland epithelial cell proliferation 0.040030632161996 0.166515380439741 1.34748918593684 0.583333333333333 26.2 26 2 increased fibrosarcoma incidence 0.040030632161996 0.166515380439741 1.34748918593684 0.583333333333333 26.2 26 2 hydrops fetalis 6.85811016220643e-07 2.23000640895275e-05 1.34748918593684 0.583333333333333 26.2 26 2 kidney cysts 5.87821139580733e-07 1.96536548091158e-05 1.34228652498728 0.581081081081081 26.2 26 2 abnormal postnatal growth/weight/body size 0.00117225751024083 0.0124084704541449 1.34127955835188 0.580645161290323 26.2 26 2 abnormal retinal photoreceptor layer morphology 0.00117225751024083 0.0124084704541449 1.34127955835188 0.580645161290323 26.2 26 2 decreased thymus weight 0.00117225751024083 0.0124084704541449 1.34127955835188 0.580645161290323 26.2 26 2 abnormal hindlimb morphology 4.14954706327077e-05 0.000787938803044736 1.33978924773149 0.58 26.2 26 2 decreased neuron apoptosis 0.000360359573367805 0.00460871176736461 1.33735768829822 0.578947368421053 26.2 26 2 small superior vagus ganglion 0.0111342768656369 0.0668997915537963 1.33735768829822 0.578947368421053 26.2 26 2 increased liver adenoma incidence 0.0111342768656369 0.0668997915537963 1.33735768829822 0.578947368421053 26.2 26 2 increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 0.0111342768656369 0.0668997915537963 1.33735768829822 0.578947368421053 26.2 26 2 increased sacral vertebrae number 4.1858217787015e-06 0.000111959480371183 1.33545803249097 0.578125 26.2 26 2 abnormal nasal bone morphology 0.0032716871547845 0.0274943303970488 1.33268161246501 0.576923076923077 26.2 26 2 abnormal xiphoid process morphology 0.0032716871547845 0.0274943303970488 1.33268161246501 0.576923076923077 26.2 26 2 abnormal stomach morphology 0.0032716871547845 0.0274943303970488 1.33268161246501 0.576923076923077 26.2 26 2 abnormal ureter morphology 0.0032716871547845 0.0274943303970488 1.33268161246501 0.576923076923077 26.2 26 2 abnormal Schwann cell morphology 0.0032716871547845 0.0274943303970488 1.33268161246501 0.576923076923077 26.2 26 2 abnormal nerve conduction 0.0032716871547845 0.0274943303970488 1.33268161246501 0.576923076923077 26.2 26 2 embryonic lethality before implantation, complete penetrance 1.88600691984623e-10 1.48453889823623e-08 1.33054932188506 0.576 26.2 26 2 abnormal neuron morphology 1.44946727072522e-08 7.28393906248278e-07 1.32998932637922 0.575757575757576 26.2 26 2 impaired swimming 3.57145327026064e-06 9.81656354671087e-05 1.32998932637922 0.575757575757576 26.2 26 2 abnormal tooth development 0.000990257177223085 0.0107566145342464 1.32998932637922 0.575757575757576 26.2 26 2 seminiferous tubule degeneration 1.14368173365509e-06 3.5561353905838e-05 1.3290304299651 0.575342465753425 26.2 26 2 cleft secondary palate 3.82810578483491e-08 1.68538285659767e-06 1.32701062688005 0.574468085106383 26.2 26 2 pulmonary hypoplasia 9.53579545217463e-05 0.00157088021107844 1.32701062688005 0.574468085106383 26.2 26 2 increased cellular sensitivity to gamma-irradiation 9.53579545217463e-05 0.00157088021107844 1.32701062688005 0.574468085106383 26.2 26 2 abnormal maxilla morphology 3.00552116986413e-05 0.000610304808982615 1.32610046869975 0.574074074074074 26.2 26 2 impaired limb coordination 3.00552116986413e-05 0.000610304808982615 1.32610046869975 0.574074074074074 26.2 26 2 abnormal apoptosis 3.00552116986413e-05 0.000610304808982615 1.32610046869975 0.574074074074074 26.2 26 2 increased osteoclast cell number 9.53887896664706e-06 0.000227061831861575 1.32539919928214 0.573770491803279 26.2 26 2 increased startle reflex 1.0115387453381e-07 4.02592420644564e-06 1.32369724204389 0.573033707865168 26.2 26 2 abnormal long bone hypertrophic chondrocyte zone 8.08639296395297e-05 0.0013730308872241 1.31998940663201 0.571428571428571 26.2 26 2 abnormal erythropoiesis 9.04140724930859e-09 4.83666678121616e-07 1.31998940663201 0.571428571428571 26.2 26 2 abnormal cartilage morphology 0.000258347513555961 0.00354071316788128 1.31998940663201 0.571428571428571 26.2 26 2 disheveled coat 0.000258347513555961 0.00354071316788128 1.31998940663201 0.571428571428571 26.2 26 2 spina bifida 0.000258347513555961 0.00354071316788128 1.31998940663201 0.571428571428571 26.2 26 2 increased carcinoma incidence 0.000835146458086085 0.0091921540464121 1.31998940663201 0.571428571428571 26.2 26 2 abnormal midbrain development 0.000835146458086085 0.0091921540464121 1.31998940663201 0.571428571428571 26.2 26 2 decreased glycogen level 0.000835146458086085 0.0091921540464121 1.31998940663201 0.571428571428571 26.2 26 2 lymphoid hyperplasia 0.00274579572557509 0.0237984908270664 1.31998940663201 0.571428571428571 26.2 26 2 absent corpus callosum 0.00274579572557509 0.0237984908270664 1.31998940663201 0.571428571428571 26.2 26 2 abnormal hormone level 0.00274579572557509 0.0237984908270664 1.31998940663201 0.571428571428571 26.2 26 2 increased bone resorption 0.00274579572557509 0.0237984908270664 1.31998940663201 0.571428571428571 26.2 26 2 abnormal mitotic spindle morphology 0.00274579572557509 0.0237984908270664 1.31998940663201 0.571428571428571 26.2 26 2 abnormal eye pigmentation 0.00926806462385796 0.0589624315904007 1.31998940663201 0.571428571428571 26.2 26 2 abnormal erythrocyte physiology 0.00926806462385796 0.0589624315904007 1.31998940663201 0.571428571428571 26.2 26 2 complete atrioventricular septal defect 0.00926806462385796 0.0589624315904007 1.31998940663201 0.571428571428571 26.2 26 2 embryonic lethality at implantation, complete penetrance 0.00926806462385796 0.0589624315904007 1.31998940663201 0.571428571428571 26.2 26 2 absent segment of posterior cerebral artery 0.00926806462385796 0.0589624315904007 1.31998940663201 0.571428571428571 26.2 26 2 abnormal interparietal bone morphology 0.0327684972585665 0.140416256555873 1.31998940663201 0.571428571428571 26.2 26 2 abnormal blood flow velocity 0.0327684972585665 0.140416256555873 1.31998940663201 0.571428571428571 26.2 26 2 increased lactate dehydrogenase level 0.0327684972585665 0.140416256555873 1.31998940663201 0.571428571428571 26.2 26 2 intestinal obstruction 0.0327684972585665 0.140416256555873 1.31998940663201 0.571428571428571 26.2 26 2 failure of zygotic cell division 0.0327684972585665 0.140416256555873 1.31998940663201 0.571428571428571 26.2 26 2 absent olfactory bulb 0.0327684972585665 0.140416256555873 1.31998940663201 0.571428571428571 26.2 26 2 split sternum 0.0327684972585665 0.140416256555873 1.31998940663201 0.571428571428571 26.2 26 2 increased stomach tumor incidence 0.0327684972585665 0.140416256555873 1.31998940663201 0.571428571428571 26.2 26 2 testis degeneration 0.0327684972585665 0.140416256555873 1.31998940663201 0.571428571428571 26.2 26 2 multiple persisting craniopharyngeal ducts 0.0327684972585665 0.140416256555873 1.31998940663201 0.571428571428571 26.2 26 2 abnormal forebrain development 2.20421222376288e-06 6.5296680966436e-05 1.3154061100812 0.569444444444444 26.2 26 2 decreased leukocyte cell number 7.36388445034068e-11 6.10588752340748e-09 1.31517192704576 0.569343065693431 26.2 26 2 prenatal lethality, incomplete penetrance 3.07324904096052e-22 8.99377292869329e-20 1.31456181861132 0.569078947368421 26.2 26 2 abnormal embryonic neuroepithelium morphology 2.16622208483112e-05 0.000456650630170967 1.31429979712066 0.568965517241379 26.2 26 2 microphthalmia 6.68496338093569e-12 6.78728424901123e-10 1.31351887032499 0.568627450980392 26.2 26 2 increased kidney weight 6.84929143350862e-05 0.00119562192567387 1.31351887032499 0.568627450980392 26.2 26 2 failure of chorioallantoic fusion 6.84929143350862e-05 0.00119562192567387 1.31351887032499 0.568627450980392 26.2 26 2 omphalocele 0.000218309412654793 0.00310483395010892 1.3124894668216 0.568181818181818 26.2 26 2 embryonic lethality, incomplete penetrance 0.000218309412654793 0.00310483395010892 1.3124894668216 0.568181818181818 26.2 26 2 abnormal neural tube morphology 1.86223914065511e-12 2.20586660113314e-10 1.31184132387502 0.567901234567901 26.2 26 2 abnormal vocalization 0.00070340342573439 0.0079895708744945 1.3110705592899 0.567567567567568 26.2 26 2 decreased erythrocyte cell number 4.86403359889466e-12 5.26055807706542e-10 1.30947993683398 0.56687898089172 26.2 26 2 abnormal incisor morphology 1.83628444762584e-05 0.000397196309866894 1.30898949491007 0.566666666666667 26.2 26 2 abnormal response to new environment 0.00230142104454306 0.020779618324141 1.30898949491007 0.566666666666667 26.2 26 2 short tail 5.11580077866964e-07 1.76743811624177e-05 1.30806179151184 0.566265060240964 26.2 26 2 abnormal embryo development 1.40084427667751e-10 1.12406456072106e-08 1.30785715105634 0.566176470588235 26.2 26 2 decreased circulating serum albumin level 4.53717657847935e-08 1.94590116189093e-06 1.30665618030239 0.565656565656566 26.2 26 2 increased mean corpuscular hemoglobin 4.53717657847935e-08 1.94590116189093e-06 1.30665618030239 0.565656565656566 26.2 26 2 abnormal pulmonary artery morphology 0.00770692808459767 0.0522370125624978 1.30564169569035 0.565217391304348 26.2 26 2 abnormal postnatal growth 0.00770692808459767 0.0522370125624978 1.30564169569035 0.565217391304348 26.2 26 2 abnormal cochlear ganglion morphology 0.00770692808459767 0.0522370125624978 1.30564169569035 0.565217391304348 26.2 26 2 dilated heart 0.00770692808459767 0.0522370125624978 1.30564169569035 0.565217391304348 26.2 26 2 abnormal ulna morphology 0.00770692808459767 0.0522370125624978 1.30564169569035 0.565217391304348 26.2 26 2 abnormal corneal stroma morphology 0.00770692808459767 0.0522370125624978 1.30564169569035 0.565217391304348 26.2 26 2 abnormal basicranium morphology 0.00770692808459767 0.0522370125624978 1.30564169569035 0.565217391304348 26.2 26 2 abnormal hepatocyte physiology 0.00770692808459767 0.0522370125624978 1.30564169569035 0.565217391304348 26.2 26 2 abnormal hematopoietic stem cell physiology 0.00770692808459767 0.0522370125624978 1.30564169569035 0.565217391304348 26.2 26 2 abnormal sternum morphology 4.96335293529345e-06 0.000129961478174131 1.30564169569035 0.565217391304348 26.2 26 2 cleft palate 3.66096835600126e-10 2.7184056076278e-08 1.30487502411332 0.564885496183206 26.2 26 2 short snout 1.25089553155518e-08 6.48250548904898e-07 1.30471175146265 0.564814814814815 26.2 26 2 impaired macrophage chemotaxis 0.000591808264370176 0.00706054224278567 1.30306646552134 0.564102564102564 26.2 26 2 embryonic growth arrest 1.7662796535467e-16 3.1383004558553e-14 1.30125593252042 0.563318777292576 26.2 26 2 lethality throughout fetal growth and development, complete penetrance 6.49253187996159e-14 8.72982327102944e-12 1.30088429679917 0.563157894736842 26.2 26 2 abnormal craniofacial morphology 3.27766968786823e-08 1.49600061441692e-06 1.30076625993348 0.563106796116505 26.2 26 2 abnormal rib morphology 2.65033022148444e-10 1.99778679574017e-08 1.30043400801524 0.562962962962963 26.2 26 2 overriding aortic valve 0.000155414984722744 0.00238297896076008 1.29936457215338 0.5625 26.2 26 2 oligodactyly 0.000155414984722744 0.00238297896076008 1.29936457215338 0.5625 26.2 26 2 small heart 0.000155414984722744 0.00238297896076008 1.29936457215338 0.5625 26.2 26 2 bradykinesia 0.0019270733798734 0.0178200558826583 1.29936457215338 0.5625 26.2 26 2 paternal imprinting 0.0268424492627095 0.126765307330344 1.29936457215338 0.5625 26.2 26 2 decreased cochlear coiling 0.0268424492627095 0.126765307330344 1.29936457215338 0.5625 26.2 26 2 increased pancreatic beta cell number 0.0268424492627095 0.126765307330344 1.29936457215338 0.5625 26.2 26 2 bowed tibia 0.0268424492627095 0.126765307330344 1.29936457215338 0.5625 26.2 26 2 increased thymus weight 0.0268424492627095 0.126765307330344 1.29936457215338 0.5625 26.2 26 2 decreased liver cholesterol level 0.0268424492627095 0.126765307330344 1.29936457215338 0.5625 26.2 26 2 abnormal pulmonary alveolus wall morphology 0.0268424492627095 0.126765307330344 1.29936457215338 0.5625 26.2 26 2 decreased adipocyte glucose uptake 0.0268424492627095 0.126765307330344 1.29936457215338 0.5625 26.2 26 2 decreased body length 2.95990690104918e-19 7.36276841635984e-17 1.29831074849389 0.562043795620438 26.2 26 2 astrocytosis 3.56301691421342e-06 9.81656354671087e-05 1.29738684829927 0.561643835616438 26.2 26 2 abnormal developmental patterning 9.70111488528584e-07 3.08090595124865e-05 1.29584325894971 0.560975609756098 26.2 26 2 abnormal cell differentiation 0.000497481936502165 0.00606610939729968 1.29584325894971 0.560975609756098 26.2 26 2 embryonic lethality during organogenesis, incomplete penetrance 2.82789993807304e-16 4.6896007306378e-14 1.2955982980312 0.560869565217391 26.2 26 2 decreased circulating alkaline phosphatase level 0.000130969241102757 0.00206193662812094 1.29358961849937 0.56 26.2 26 2 mandible hypoplasia 0.00640505927814324 0.0454969088407215 1.29358961849937 0.56 26.2 26 2 abnormal egg cylinder morphology 0.00640505927814324 0.0454969088407215 1.29358961849937 0.56 26.2 26 2 decreased total body fat amount 8.39304742580288e-23 2.60971318396058e-20 1.29331297401295 0.559880239520958 26.2 26 2 syndactyly 3.49376652028866e-05 0.000684310568442366 1.29202352937285 0.559322033898305 26.2 26 2 embryonic lethality during organogenesis, complete penetrance 4.61452387237965e-37 3.27960803786982e-34 1.29111463836193 0.558928571428571 26.2 26 2 abnormal spleen red pulp morphology 0.00161242962573431 0.0158221644734284 1.29087199325042 0.558823529411765 26.2 26 2 hyperactivity 7.89816256628027e-25 3.0225660590188e-22 1.28885758100389 0.557951482479784 26.2 26 2 eyelids open at birth 0.000110294961791777 0.00178155011335743 1.28825889204951 0.557692307692308 26.2 26 2 preweaning lethality, incomplete penetrance 3.93198703085356e-27 1.95616354784964e-24 1.28771582700775 0.557457212713936 26.2 26 2 abnormal long bone morphology 2.94745047476204e-05 0.000605932483964511 1.28753065073122 0.557377049180328 26.2 26 2 small kidney 5.88622023428796e-07 1.96536548091158e-05 1.28623967748516 0.556818181818182 26.2 26 2 abnormal myocardial fiber morphology 1.61256961407272e-07 6.21901847287736e-06 1.28596906110025 0.556701030927835 26.2 26 2 abnormal skeleton morphology 1.22127164737304e-08 6.39560678492721e-07 1.28555490037204 0.556521739130435 26.2 26 2 decreased startle reflex 1.03449870219229e-08 5.47513940787942e-07 1.28332303422556 0.555555555555556 26.2 26 2 abnormal motor coordination/ balance 1.36473701776717e-07 5.34611548298558e-06 1.28332303422556 0.555555555555556 26.2 26 2 abnormal neuromuscular synapse morphology 6.7098696222478e-06 0.000169449753150674 1.28332303422556 0.555555555555556 26.2 26 2 abnormal digit morphology 6.7098696222478e-06 0.000169449753150674 1.28332303422556 0.555555555555556 26.2 26 2 abnormal autopod morphology 0.000350822702869252 0.00449830656385188 1.28332303422556 0.555555555555556 26.2 26 2 irregular heartbeat 0.000350822702869252 0.00449830656385188 1.28332303422556 0.555555555555556 26.2 26 2 abnormal metabolism 0.000350822702869252 0.00449830656385188 1.28332303422556 0.555555555555556 26.2 26 2 heart right ventricle hypertrophy 0.00134841447679504 0.0137098077726584 1.28332303422556 0.555555555555556 26.2 26 2 narrow eye opening 0.00134841447679504 0.0137098077726584 1.28332303422556 0.555555555555556 26.2 26 2 decreased susceptibility to pharmacologically induced seizures 0.00532151717363272 0.0395733153046678 1.28332303422556 0.555555555555556 26.2 26 2 delayed kidney development 0.0220102941143516 0.112551465351751 1.28332303422556 0.555555555555556 26.2 26 2 absent spleen 0.0220102941143516 0.112551465351751 1.28332303422556 0.555555555555556 26.2 26 2 abnormal phrenic nerve morphology 0.0220102941143516 0.112551465351751 1.28332303422556 0.555555555555556 26.2 26 2 decreased cellular sensitivity to gamma-irradiation 0.0220102941143516 0.112551465351751 1.28332303422556 0.555555555555556 26.2 26 2 increased circulating glycerol level 0.0220102941143516 0.112551465351751 1.28332303422556 0.555555555555556 26.2 26 2 abnormal eye anterior chamber morphology 0.0220102941143516 0.112551465351751 1.28332303422556 0.555555555555556 26.2 26 2 jerky movement 0.0220102941143516 0.112551465351751 1.28332303422556 0.555555555555556 26.2 26 2 heart hyperplasia 0.101393720491541 0.292086716528905 1.28332303422556 0.555555555555556 26.2 26 2 abnormal head movements 0.101393720491541 0.292086716528905 1.28332303422556 0.555555555555556 26.2 26 2 renal tubular acidosis 0.101393720491541 0.292086716528905 1.28332303422556 0.555555555555556 26.2 26 2 synostosis 0.101393720491541 0.292086716528905 1.28332303422556 0.555555555555556 26.2 26 2 abnormal cholinergic neuron morphology 0.101393720491541 0.292086716528905 1.28332303422556 0.555555555555556 26.2 26 2 abnormal geniculate ganglion morphology 0.101393720491541 0.292086716528905 1.28332303422556 0.555555555555556 26.2 26 2 abnormal lens vesicle development 0.101393720491541 0.292086716528905 1.28332303422556 0.555555555555556 26.2 26 2 decreased level of surface class I molecules 0.101393720491541 0.292086716528905 1.28332303422556 0.555555555555556 26.2 26 2 abnormal lung volume 0.101393720491541 0.292086716528905 1.28332303422556 0.555555555555556 26.2 26 2 abnormal germ cell morphology 0.101393720491541 0.292086716528905 1.28332303422556 0.555555555555556 26.2 26 2 polycythemia 0.101393720491541 0.292086716528905 1.28332303422556 0.555555555555556 26.2 26 2 abnormal postural reflex 0.101393720491541 0.292086716528905 1.28332303422556 0.555555555555556 26.2 26 2 genetic imprinting 0.101393720491541 0.292086716528905 1.28332303422556 0.555555555555556 26.2 26 2 priapism 0.101393720491541 0.292086716528905 1.28332303422556 0.555555555555556 26.2 26 2 abnormal thymus physiology 0.101393720491541 0.292086716528905 1.28332303422556 0.555555555555556 26.2 26 2 short frontal bone 0.101393720491541 0.292086716528905 1.28332303422556 0.555555555555556 26.2 26 2 decreased cochlear hair cell number 0.101393720491541 0.292086716528905 1.28332303422556 0.555555555555556 26.2 26 2 decreased susceptibility to atherosclerosis 0.101393720491541 0.292086716528905 1.28332303422556 0.555555555555556 26.2 26 2 abnormal retinal development 0.101393720491541 0.292086716528905 1.28332303422556 0.555555555555556 26.2 26 2 multiflagellated sperm 0.101393720491541 0.292086716528905 1.28332303422556 0.555555555555556 26.2 26 2 abnormal telomere morphology 0.101393720491541 0.292086716528905 1.28332303422556 0.555555555555556 26.2 26 2 retropulsion 0.101393720491541 0.292086716528905 1.28332303422556 0.555555555555556 26.2 26 2 decreased effector memory CD4-positive, alpha-beta T cell number 0.101393720491541 0.292086716528905 1.28332303422556 0.555555555555556 26.2 26 2 abnormal pulmonary alveolar parenchyma morphology 0.101393720491541 0.292086716528905 1.28332303422556 0.555555555555556 26.2 26 2 reduced AMPA-mediated synaptic currents 0.101393720491541 0.292086716528905 1.28332303422556 0.555555555555556 26.2 26 2 cataract 7.41504209423538e-09 4.0538279581122e-07 1.27908064402977 0.553719008264463 26.2 26 2 enhanced long term potentiation 7.80926675684418e-05 0.0013348897271717 1.27873973767476 0.553571428571429 26.2 26 2 increased respiratory quotient 0.000294375073969977 0.00385398945526483 1.27786208514375 0.553191489361702 26.2 26 2 insulin resistance 1.73510884429016e-09 1.1210605844602e-07 1.27748974770635 0.553030303030303 26.2 26 2 abnormal cell morphology 2.27324825247748e-08 1.06692547698825e-06 1.27656870246648 0.552631578947368 26.2 26 2 increased grooming behavior 0.00112716347865783 0.012033558597259 1.27656870246648 0.552631578947368 26.2 26 2 abnormal cranium morphology 1.46839216515769e-09 9.61217239692044e-08 1.27566140417048 0.552238805970149 26.2 26 2 hypoactivity 4.13110316039838e-24 1.46801701592728e-21 1.27447253054125 0.551724137931034 26.2 26 2 abnormal parietal bone morphology 0.00442077923255528 0.0340136661231006 1.27447253054125 0.551724137931034 26.2 26 2 short sternum 0.00442077923255528 0.0340136661231006 1.27447253054125 0.551724137931034 26.2 26 2 abnormal cornea morphology 4.02760672535977e-06 0.000108309964641432 1.27345131857767 0.551282051282051 26.2 26 2 polydactyly 2.53787736402906e-07 9.216014515361e-06 1.27284692782372 0.551020408163265 26.2 26 2 increased sarcoma incidence 0.000246909461415782 0.00341353903860661 1.27284692782372 0.551020408163265 26.2 26 2 perimembraneous ventricular septal defect 1.48570556712937e-05 0.000335972054384937 1.27216370349316 0.550724637681159 26.2 26 2 abnormal posture 3.39495355190281e-06 9.48870444984072e-05 1.27048980388331 0.55 26.2 26 2 abnormal kidney development 5.51957794243215e-05 0.00099938688167518 1.27048980388331 0.55 26.2 26 2 abnormal eating behavior 5.51957794243215e-05 0.00099938688167518 1.27048980388331 0.55 26.2 26 2 abnormal basioccipital bone morphology 0.0180681321527371 0.0966547929675991 1.27048980388331 0.55 26.2 26 2 abnormal vascular regression 0.0180681321527371 0.0966547929675991 1.27048980388331 0.55 26.2 26 2 small gonad 0.0180681321527371 0.0966547929675991 1.27048980388331 0.55 26.2 26 2 abnormal hyoid bone morphology 0.0180681321527371 0.0966547929675991 1.27048980388331 0.55 26.2 26 2 abnormal response to tactile stimuli 0.0180681321527371 0.0966547929675991 1.27048980388331 0.55 26.2 26 2 corneal opacity 1.25063250511508e-05 0.000285408106098509 1.26886305637513 0.549295774647887 26.2 26 2 abnormal bone structure 7.53219496994643e-13 9.13967560377646e-11 1.26869448150382 0.549222797927461 26.2 26 2 abnormal extraembryonic tissue morphology 1.8084144336468e-07 6.81580439954003e-06 1.26822511617585 0.549019607843137 26.2 26 2 increased lung adenocarcinoma incidence 0.000207027378037313 0.00298539479923372 1.26822511617585 0.549019607843137 26.2 26 2 abnormal cervical vertebrae morphology 0.000207027378037313 0.00298539479923372 1.26822511617585 0.549019607843137 26.2 26 2 osteopetrosis 0.00367254819333861 0.0301354487453125 1.26676402733233 0.548387096774194 26.2 26 2 increased lung adenoma incidence 0.00367254819333861 0.0301354487453125 1.26676402733233 0.548387096774194 26.2 26 2 inner cell mass degeneration 0.00367254819333861 0.0301354487453125 1.26676402733233 0.548387096774194 26.2 26 2 decreased neuronal precursor cell number 0.00367254819333861 0.0301354487453125 1.26676402733233 0.548387096774194 26.2 26 2 abnormal fertility/fecundity 1.05242365410774e-05 0.000245812567097934 1.26574326663343 0.547945205479452 26.2 26 2 abnormal testis morphology 3.54775837020016e-08 1.59009890916629e-06 1.26546810505373 0.547826086956522 26.2 26 2 abnormal vitelline vasculature morphology 3.54775837020016e-08 1.59009890916629e-06 1.26546810505373 0.547826086956522 26.2 26 2 abnormal liver morphology 6.95153766218712e-12 6.8415555329136e-10 1.26468258791837 0.547486033519553 26.2 26 2 prenatal lethality, complete penetrance 1.54994452105455e-17 3.08438959689856e-15 1.2630114466335 0.546762589928058 26.2 26 2 abnormal spatial learning 7.58899878779751e-11 6.18938835562174e-09 1.2612782213677 0.54601226993865 26.2 26 2 abnormal suckling behavior 1.70883197812498e-06 5.15238732798288e-05 1.25998988814873 0.545454545454545 26.2 26 2 abnormal contextual conditioning behavior 0.000145433069245032 0.00226811761596876 1.25998988814873 0.545454545454545 26.2 26 2 abnormal circadian rhythm 0.000657385233922849 0.00762729783657418 1.25998988814873 0.545454545454545 26.2 26 2 abnormal middle ear ossicle morphology 0.00305125282305376 0.0261273369960283 1.25998988814873 0.545454545454545 26.2 26 2 cardiovascular system phenotype 0.00305125282305376 0.0261273369960283 1.25998988814873 0.545454545454545 26.2 26 2 abnormal germ layer development 0.014848682618059 0.082354733583995 1.25998988814873 0.545454545454545 26.2 26 2 increased coping response 0.014848682618059 0.082354733583995 1.25998988814873 0.545454545454545 26.2 26 2 abnormal cochlear sensory epithelium morphology 0.014848682618059 0.082354733583995 1.25998988814873 0.545454545454545 26.2 26 2 parakeratosis 0.014848682618059 0.082354733583995 1.25998988814873 0.545454545454545 26.2 26 2 prolonged PR interval 0.014848682618059 0.082354733583995 1.25998988814873 0.545454545454545 26.2 26 2 abnormal basement membrane morphology 0.014848682618059 0.082354733583995 1.25998988814873 0.545454545454545 26.2 26 2 failure of palatal shelf elevation 0.014848682618059 0.082354733583995 1.25998988814873 0.545454545454545 26.2 26 2 premature suture closure 0.0806114057981424 0.272054586125999 1.25998988814873 0.545454545454545 26.2 26 2 abnormal sebaceous gland morphology 0.0806114057981424 0.272054586125999 1.25998988814873 0.545454545454545 26.2 26 2 social withdrawal 0.0806114057981424 0.272054586125999 1.25998988814873 0.545454545454545 26.2 26 2 failure of somite differentiation 0.0806114057981424 0.272054586125999 1.25998988814873 0.545454545454545 26.2 26 2 abnormal fear/anxiety-related behavior 0.0806114057981424 0.272054586125999 1.25998988814873 0.545454545454545 26.2 26 2 retinal detachment 0.0806114057981424 0.272054586125999 1.25998988814873 0.545454545454545 26.2 26 2 loss of cortex neurons 0.0806114057981424 0.272054586125999 1.25998988814873 0.545454545454545 26.2 26 2 pulmonary hypertension 0.0806114057981424 0.272054586125999 1.25998988814873 0.545454545454545 26.2 26 2 dilated renal glomerular capsule 0.0806114057981424 0.272054586125999 1.25998988814873 0.545454545454545 26.2 26 2 abnormal pituitary gland development 0.0806114057981424 0.272054586125999 1.25998988814873 0.545454545454545 26.2 26 2 abnormal coronal suture morphology 0.0806114057981424 0.272054586125999 1.25998988814873 0.545454545454545 26.2 26 2 abnormal crista ampullaris neuroepithelium morphology 0.0806114057981424 0.272054586125999 1.25998988814873 0.545454545454545 26.2 26 2 cyclopia 0.0806114057981424 0.272054586125999 1.25998988814873 0.545454545454545 26.2 26 2 increased motor neuron number 0.0806114057981424 0.272054586125999 1.25998988814873 0.545454545454545 26.2 26 2 abnormal palate development 0.0806114057981424 0.272054586125999 1.25998988814873 0.545454545454545 26.2 26 2 palatal shelf hypoplasia 0.0806114057981424 0.272054586125999 1.25998988814873 0.545454545454545 26.2 26 2 abnormal palatal shelf elevation 0.0806114057981424 0.272054586125999 1.25998988814873 0.545454545454545 26.2 26 2 decreased embryonic cilium length 0.0806114057981424 0.272054586125999 1.25998988814873 0.545454545454545 26.2 26 2 increased hepatocellular carcinoma incidence 0.00012185588361201 0.00192454927291983 1.25630570718923 0.543859649122807 26.2 26 2 abnormal locomotor behavior 1.21059715046326e-06 3.74082038730105e-05 1.25542470739457 0.543478260869565 26.2 26 2 abnormal behavior 4.36028032241818e-17 8.03422022371498e-15 1.25470216080039 0.543165467625899 26.2 26 2 curly tail 0.000458600633989427 0.0057038453852435 1.25123995836992 0.541666666666667 26.2 26 2 abnormal malleus morphology 0.0122161360367846 0.0698566399804638 1.25123995836992 0.541666666666667 26.2 26 2 abnormal impulse conducting system conduction 0.0122161360367846 0.0698566399804638 1.25123995836992 0.541666666666667 26.2 26 2 abnormal inner cell mass apoptosis 0.0122161360367846 0.0698566399804638 1.25123995836992 0.541666666666667 26.2 26 2 neonatal lethality, complete penetrance 8.6519653171759e-27 3.91304795026819e-24 1.25123995836992 0.541666666666667 26.2 26 2 increased bone mineral content 1.67117029552481e-07 6.39544016941224e-06 1.25035693793353 0.541284403669725 26.2 26 2 abnormal maternal nurturing 8.55101388647198e-05 0.00144207776559994 1.2496621021803 0.540983606557377 26.2 26 2 edema 5.91004025421031e-11 4.98346614655869e-09 1.24900160424046 0.540697674418605 26.2 26 2 abnormal long bone metaphysis morphology 0.00210725100745462 0.0193067656760345 1.24863862789514 0.540540540540541 26.2 26 2 abnormal breathing pattern 0.00210725100745462 0.0193067656760345 1.24863862789514 0.540540540540541 26.2 26 2 abnormal chromosome morphology 0.00210725100745462 0.0193067656760345 1.24863862789514 0.540540540540541 26.2 26 2 abnormal humerus morphology 0.00210725100745462 0.0193067656760345 1.24863862789514 0.540540540540541 26.2 26 2 impaired coordination 1.73475486896765e-20 4.54231867006004e-18 1.24845818878706 0.540462427745665 26.2 26 2 premature death 5.32632824885067e-49 6.62462075950802e-46 1.24755096358513 0.54006968641115 26.2 26 2 kyphosis 1.07161925371577e-09 7.20446728004859e-08 1.24738998926725 0.54 26.2 26 2 decreased double-positive T cell number 6.06222484583819e-07 1.99732242437384e-05 1.24738998926725 0.54 26.2 26 2 perinatal lethality, incomplete penetrance 7.745891217681e-14 1.0141002317885e-11 1.24698114299086 0.539823008849557 26.2 26 2 kinked tail 5.09766695266051e-07 1.76743811624177e-05 1.24557823910128 0.53921568627451 26.2 26 2 abnormal nervous system physiology 9.96065149288286e-08 3.99630977234615e-06 1.24538130973541 0.539130434782609 26.2 26 2 limb grasping 2.51355980310733e-11 2.2736290946289e-09 1.24383617163401 0.538461538461538 26.2 26 2 increased insulin sensitivity 3.24298397483108e-09 1.92069586604579e-07 1.24383617163401 0.538461538461538 26.2 26 2 increased grip strength 2.2049934477108e-06 6.5296680966436e-05 1.24383617163401 0.538461538461538 26.2 26 2 decreased kidney weight 0.000319881863657106 0.00417693509630998 1.24383617163401 0.538461538461538 26.2 26 2 small lens 0.00175174456199341 0.0166952666588453 1.24383617163401 0.538461538461538 26.2 26 2 increased hepatocyte apoptosis 0.00175174456199341 0.0166952666588453 1.24383617163401 0.538461538461538 26.2 26 2 heart inflammation 0.0100606600887284 0.0626430337189287 1.24383617163401 0.538461538461538 26.2 26 2 tight skin 0.0645451912770613 0.239549177973002 1.24383617163401 0.538461538461538 26.2 26 2 abnormal grip strength 0.0645451912770613 0.239549177973002 1.24383617163401 0.538461538461538 26.2 26 2 abnormal pulmonary alveolus epithelial cell morphology 0.0645451912770613 0.239549177973002 1.24383617163401 0.538461538461538 26.2 26 2 abnormal coping response 0.0645451912770613 0.239549177973002 1.24383617163401 0.538461538461538 26.2 26 2 anal atresia 0.0645451912770613 0.239549177973002 1.24383617163401 0.538461538461538 26.2 26 2 abnormal telomere length 0.0645451912770613 0.239549177973002 1.24383617163401 0.538461538461538 26.2 26 2 tracheoesophageal fistula 0.0645451912770613 0.239549177973002 1.24383617163401 0.538461538461538 26.2 26 2 abnormal afterhyperpolarization 0.0645451912770613 0.239549177973002 1.24383617163401 0.538461538461538 26.2 26 2 small interparietal bone 0.0645451912770613 0.239549177973002 1.24383617163401 0.538461538461538 26.2 26 2 abnormal exocrine pancreas morphology 0.0645451912770613 0.239549177973002 1.24383617163401 0.538461538461538 26.2 26 2 hyperalgesia 0.0645451912770613 0.239549177973002 1.24383617163401 0.538461538461538 26.2 26 2 abnormal aorta tunica media morphology 0.0645451912770613 0.239549177973002 1.24383617163401 0.538461538461538 26.2 26 2 abnormal heart development 5.39562692051071e-10 3.89032520717982e-08 1.2427115458007 0.537974683544304 26.2 26 2 decreased body weight 7.40581434420215e-69 3.68439263624057e-65 1.24082202905331 0.537156704361874 26.2 26 2 abnormal cell adhesion 0.000267159740534009 0.00360195043131896 1.24054559975138 0.537037037037037 26.2 26 2 impaired righting response 1.55539776765188e-06 4.74730300249576e-05 1.24009531096744 0.536842105263158 26.2 26 2 decreased birth weight 1.55539776765188e-06 4.74730300249576e-05 1.24009531096744 0.536842105263158 26.2 26 2 abnormal excitatory postsynaptic potential 8.04681832565287e-06 0.000196239809657466 1.23950224769103 0.536585365853659 26.2 26 2 abnormal neuron differentiation 2.13930266876711e-07 7.94256028143012e-06 1.23749006871751 0.535714285714286 26.2 26 2 rib bifurcation 0.00829350345985304 0.0540154520662669 1.23749006871751 0.535714285714286 26.2 26 2 small superior cervical ganglion 0.00829350345985304 0.0540154520662669 1.23749006871751 0.535714285714286 26.2 26 2 abnormal respiration 0.00829350345985304 0.0540154520662669 1.23749006871751 0.535714285714286 26.2 26 2 failure of blastocyst to hatch from the zona pellucida 0.00829350345985304 0.0540154520662669 1.23749006871751 0.535714285714286 26.2 26 2 premature aging 0.00829350345985304 0.0540154520662669 1.23749006871751 0.535714285714286 26.2 26 2 decreased exploration in new environment 6.74925453907166e-06 0.00016958354208021 1.23749006871751 0.535714285714286 26.2 26 2 increased circulating free fatty acid level 3.5217628131167e-05 0.000687089019421788 1.23632810621167 0.535211267605634 26.2 26 2 abnormal left-right axis patterning 0.00121139223312786 0.0126804652612565 1.23557147946368 0.534883720930233 26.2 26 2 kidney failure 0.00121139223312786 0.0126804652612565 1.23557147946368 0.534883720930233 26.2 26 2 cochlear ganglion degeneration 0.000186370240846263 0.00273507949324531 1.23464526396183 0.53448275862069 26.2 26 2 abnormal gait 1.39500170804739e-17 2.89172229063991e-15 1.23348524648865 0.533980582524272 26.2 26 2 abnormal long bone epiphyseal plate morphology 0.000155671992411463 0.00238297896076008 1.23199011285654 0.533333333333333 26.2 26 2 abnormal cell migration 0.00100774241226981 0.0109226982593514 1.23199011285654 0.533333333333333 26.2 26 2 abnormal heart tube morphology 0.00684290287599781 0.0480161379521708 1.23199011285654 0.533333333333333 26.2 26 2 abnormal microglial cell physiology 0.00684290287599781 0.0480161379521708 1.23199011285654 0.533333333333333 26.2 26 2 decreased chondrocyte number 0.0519638319761968 0.204041092408508 1.23199011285654 0.533333333333333 26.2 26 2 hyperpigmentation 0.0519638319761968 0.204041092408508 1.23199011285654 0.533333333333333 26.2 26 2 abnormal pup retrieval 0.0519638319761968 0.204041092408508 1.23199011285654 0.533333333333333 26.2 26 2 audiogenic seizures 0.0519638319761968 0.204041092408508 1.23199011285654 0.533333333333333 26.2 26 2 abnormal seizure response to electrical stimulation 0.0519638319761968 0.204041092408508 1.23199011285654 0.533333333333333 26.2 26 2 abnormal cricoid cartilage morphology 0.0519638319761968 0.204041092408508 1.23199011285654 0.533333333333333 26.2 26 2 abnormal lymph node B cell domain morphology 0.0519638319761968 0.204041092408508 1.23199011285654 0.533333333333333 26.2 26 2 abnormal trophectoderm morphology 0.0519638319761968 0.204041092408508 1.23199011285654 0.533333333333333 26.2 26 2 abnormal olfactory nerve morphology 0.0519638319761968 0.204041092408508 1.23199011285654 0.533333333333333 26.2 26 2 abnormal energy homeostasis 0.0519638319761968 0.204041092408508 1.23199011285654 0.533333333333333 26.2 26 2 abnormal coronary vessel morphology 0.0519638319761968 0.204041092408508 1.23199011285654 0.533333333333333 26.2 26 2 abnormal placenta morphology 1.73083127732099e-05 0.00037767042125754 1.22809140996775 0.531645569620253 26.2 26 2 abnormal nervous system morphology 1.73083127732099e-05 0.00037767042125754 1.22809140996775 0.531645569620253 26.2 26 2 decreased lymphocyte cell number 5.30726432503751e-08 2.20030333475513e-06 1.22717765147819 0.53125 26.2 26 2 increased circulating follicle stimulating hormone level 0.00565075298193252 0.041341906007521 1.22717765147819 0.53125 26.2 26 2 neonatal lethality 0.00565075298193252 0.041341906007521 1.22717765147819 0.53125 26.2 26 2 abnormal long term potentiation 0.00565075298193252 0.041341906007521 1.22717765147819 0.53125 26.2 26 2 abnormal diaphragm morphology 0.00565075298193252 0.041341906007521 1.22717765147819 0.53125 26.2 26 2 retinal degeneration 2.34695944420102e-06 6.86830778523535e-05 1.22717765147819 0.53125 26.2 26 2 increased susceptibility to pharmacologically induced seizures 2.34695944420102e-06 6.86830778523535e-05 1.22717765147819 0.53125 26.2 26 2 hydroencephaly 2.70324651068088e-07 9.74539955843287e-06 1.2252945144171 0.530434782608696 26.2 26 2 abnormal motor capabilities/coordination/movement 3.74312560205216e-08 1.66268302412585e-06 1.22499016903349 0.53030303030303 26.2 26 2 postnatal lethality 7.28596571747417e-10 5.03439992283805e-08 1.22456848567066 0.530120481927711 26.2 26 2 enlarged liver sinusoidal spaces 0.00466992892003816 0.0349366862814885 1.22293136202671 0.529411764705882 26.2 26 2 lung hemorrhage 0.00466992892003816 0.0349366862814885 1.22293136202671 0.529411764705882 26.2 26 2 hydroureter 0.0420169261040935 0.172612887999889 1.22293136202671 0.529411764705882 26.2 26 2 abnormal vagus nerve morphology 0.0420169261040935 0.172612887999889 1.22293136202671 0.529411764705882 26.2 26 2 decreased growth hormone level 0.0420169261040935 0.172612887999889 1.22293136202671 0.529411764705882 26.2 26 2 pancytopenia 0.0420169261040935 0.172612887999889 1.22293136202671 0.529411764705882 26.2 26 2 abnormal lung development 1.01589843674858e-05 0.000239530555584085 1.22293136202671 0.529411764705882 26.2 26 2 thymus hypoplasia 2.21622463791736e-08 1.05006834034656e-06 1.22194671519738 0.528985507246377 26.2 26 2 decreased body size 1.52391526880725e-41 1.51629569246321e-38 1.22156914385681 0.528822055137845 26.2 26 2 extramedullary hematopoiesis 9.72265797680477e-07 3.08090595124865e-05 1.22036756462204 0.528301886792453 26.2 26 2 abnormal placenta development 0.000483786345055871 0.00597230041353091 1.22036756462204 0.528301886792453 26.2 26 2 abnormal muscle physiology 7.12194447932674e-06 0.000176276984003237 1.21987785051104 0.528089887640449 26.2 26 2 abnormal pharyngeal arch morphology 0.00386214393437001 0.0311708643263416 1.21915688251428 0.527777777777778 26.2 26 2 abnormal head morphology 0.000402931796971709 0.00508778093891942 1.21799022521044 0.527272727272727 26.2 26 2 abnormal joint morphology 0.000402931796971709 0.00508778093891942 1.21799022521044 0.527272727272727 26.2 26 2 small seminiferous tubules 4.4245617028057e-05 0.000827526107949562 1.21742266219776 0.527027027027027 26.2 26 2 neonatal lethality, incomplete penetrance 2.96924777791177e-14 4.10333547086418e-12 1.21718253938471 0.526923076923077 26.2 26 2 abnormal frontal bone morphology 0.00319623715056218 0.027236266416153 1.21577971663474 0.526315789473684 26.2 26 2 enlarged adrenal glands 0.0340947577240347 0.143801006898978 1.21577971663474 0.526315789473684 26.2 26 2 abnormal nasal septum morphology 0.0340947577240347 0.143801006898978 1.21577971663474 0.526315789473684 26.2 26 2 abnormal metatarsal bone morphology 0.0340947577240347 0.143801006898978 1.21577971663474 0.526315789473684 26.2 26 2 abnormal response to novelty 0.0340947577240347 0.143801006898978 1.21577971663474 0.526315789473684 26.2 26 2 abnormal digestive system development 0.0340947577240347 0.143801006898978 1.21577971663474 0.526315789473684 26.2 26 2 osteoarthritis 0.0340947577240347 0.143801006898978 1.21577971663474 0.526315789473684 26.2 26 2 abnormal sternebra morphology 0.0340947577240347 0.143801006898978 1.21577971663474 0.526315789473684 26.2 26 2 decreased eye pigmentation 0.0340947577240347 0.143801006898978 1.21577971663474 0.526315789473684 26.2 26 2 Leydig cell hypoplasia 0.0340947577240347 0.143801006898978 1.21577971663474 0.526315789473684 26.2 26 2 shortened RR interval 0.0340947577240347 0.143801006898978 1.21577971663474 0.526315789473684 26.2 26 2 right-sided stomach 0.0340947577240347 0.143801006898978 1.21577971663474 0.526315789473684 26.2 26 2 incomplete embryo turning 0.000335664253946924 0.004360129669415 1.21577971663474 0.526315789473684 26.2 26 2 respiratory distress 6.42360175506054e-10 4.50104489175017e-08 1.21507695379276 0.526011560693642 26.2 26 2 increased rib number 3.09079146504985e-05 0.000620027723331572 1.21422102469034 0.525641025641026 26.2 26 2 postnatal growth retardation 5.45964579577746e-31 3.39521722924911e-28 1.21160792348943 0.524509803921569 26.2 26 2 abnormal pancreas morphology 0.00219310083443969 0.0199829242698488 1.20999028941267 0.523809523809524 26.2 26 2 abnormal spleen white pulp morphology 0.00219310083443969 0.0199829242698488 1.20999028941267 0.523809523809524 26.2 26 2 increased keratinocyte proliferation 0.0277482064345042 0.12746752263311 1.20999028941267 0.523809523809524 26.2 26 2 postnatal lethality, incomplete penetrance 1.81208458110582e-28 1.00168008788905e-25 1.20786002481864 0.522887323943662 26.2 26 2 osteoporosis 0.00181816180368573 0.0168756622636875 1.20749030947587 0.522727272727273 26.2 26 2 renal interstitial fibrosis 0.00181816180368573 0.0168756622636875 1.20749030947587 0.522727272727273 26.2 26 2 lethality, incomplete penetrance 0.00181816180368573 0.0168756622636875 1.20749030947587 0.522727272727273 26.2 26 2 abnormal forelimb morphology 0.00150809351653105 0.0150110146943997 1.20520771909879 0.521739130434783 26.2 26 2 fragile skeleton 0.0226396875636531 0.113770147100176 1.20520771909879 0.521739130434783 26.2 26 2 bidirectional circling 0.0226396875636531 0.113770147100176 1.20520771909879 0.521739130434783 26.2 26 2 abnormal chondrocyte physiology 0.0226396875636531 0.113770147100176 1.20520771909879 0.521739130434783 26.2 26 2 abnormal vertebral artery topology 0.0226396875636531 0.113770147100176 1.20520771909879 0.521739130434783 26.2 26 2 abnormal ovary morphology 9.39828174179181e-05 0.00156900844514813 1.2037931560482 0.52112676056338 26.2 26 2 atelectasis 9.39828174179181e-05 0.00156900844514813 1.2037931560482 0.52112676056338 26.2 26 2 thymus atrophy 0.00125150268974369 0.0129721843609974 1.20311534458646 0.520833333333333 26.2 26 2 decreased grip strength 1.1462836904773e-11 1.09668487694703e-09 1.20245610330176 0.520547945205479 26.2 26 2 pallor 1.39131433378985e-09 9.22905174747266e-08 1.20119036003513 0.52 26.2 26 2 spontaneous skin ulceration 0.0185114691919795 0.0983916231090791 1.20119036003513 0.52 26.2 26 2 diaphragmatic hernia 0.0185114691919795 0.0983916231090791 1.20119036003513 0.52 26.2 26 2 increased cellular sensitivity to ionizing radiation 0.0185114691919795 0.0983916231090791 1.20119036003513 0.52 26.2 26 2 abnormal cochlear outer hair cell morphology 0.0185114691919795 0.0983916231090791 1.20119036003513 0.52 26.2 26 2 decreased placenta weight 0.0185114691919795 0.0983916231090791 1.20119036003513 0.52 26.2 26 2 abnormal preimplantation embryo development 0.0185114691919795 0.0983916231090791 1.20119036003513 0.52 26.2 26 2 abnormal limb morphology 6.54308772171837e-05 0.00115432132679251 1.20119036003513 0.52 26.2 26 2 distended pericardium 0.000863001859151035 0.0094569036327674 1.19941345121851 0.519230769230769 26.2 26 2 liver hypoplasia 0.000863001859151035 0.0094569036327674 1.19941345121851 0.519230769230769 26.2 26 2 increased circulating alkaline phosphatase level 6.97074958430764e-09 3.85327546465895e-07 1.19776816527719 0.518518518518518 26.2 26 2 abnormal mandible morphology 0.000717076534540955 0.0080348102687866 1.19776816527719 0.518518518518518 26.2 26 2 axon degeneration 0.000717076534540955 0.0080348102687866 1.19776816527719 0.518518518518518 26.2 26 2 decreased circulating fructosamine level 0.0151643524588316 0.0839184132176719 1.19776816527719 0.518518518518518 26.2 26 2 reduced fertility 8.46556009060197e-08 3.42407816672722e-06 1.19653715996858 0.517985611510791 26.2 26 2 reduced female fertility 5.83104363000963e-12 6.17222171474424e-10 1.19481799738242 0.517241379310345 26.2 26 2 increased blood urea nitrogen level 4.97830839892519e-08 2.09890544785193e-06 1.19481799738242 0.517241379310345 26.2 26 2 abnormal spermiogenesis 0.000495622125126198 0.00606610939729968 1.19481799738242 0.517241379310345 26.2 26 2 decreased trophoblast giant cell number 0.0124428508462434 0.0709085715464618 1.19481799738242 0.517241379310345 26.2 26 2 abnormal outer ear morphology 0.0124428508462434 0.0709085715464618 1.19481799738242 0.517241379310345 26.2 26 2 absent mesoderm 0.000412253522882444 0.00517919514227312 1.19349042182977 0.516666666666667 26.2 26 2 perinatal lethality, complete penetrance 4.91752505950344e-11 4.2662075392258e-09 1.19294817266038 0.516431924882629 26.2 26 2 pericardial effusion 0.000343016309341292 0.00443248347785176 1.19224849631278 0.516129032258065 26.2 26 2 abnormal capillary morphology 0.010224614537501 0.0633467712628486 1.19224849631278 0.516129032258065 26.2 26 2 abnormal mitochondrial ATP synthesis coupled electron transport 0.010224614537501 0.0633467712628486 1.19224849631278 0.516129032258065 26.2 26 2 azoospermia 1.44330502489264e-08 7.28393906248278e-07 1.1913111940358 0.515723270440252 26.2 26 2 cyanosis 4.95115989642176e-10 3.6223559536321e-08 1.1910841911406 0.515625 26.2 26 2 abnormal skeleton physiology 0.0084127219007412 0.0542366344351562 1.18999044991825 0.515151515151515 26.2 26 2 abnormal QRS complex 0.0084127219007412 0.0542366344351562 1.18999044991825 0.515151515151515 26.2 26 2 head tossing 0.0084127219007412 0.0542366344351562 1.18999044991825 0.515151515151515 26.2 26 2 myeloid hyperplasia 0.0084127219007412 0.0542366344351562 1.18999044991825 0.515151515151515 26.2 26 2 pericardial edema 0.000197931936437662 0.00288771666796882 1.18896104641486 0.514705882352941 26.2 26 2 abnormal liver development 0.00692996183703751 0.0480174932301694 1.18799046596881 0.514285714285714 26.2 26 2 abnormal dermal layer morphology 0.00692996183703751 0.0480174932301694 1.18799046596881 0.514285714285714 26.2 26 2 abnormal embryonic epiblast morphology 0.00692996183703751 0.0480174932301694 1.18799046596881 0.514285714285714 26.2 26 2 increased red blood cell distribution width 0.00692996183703751 0.0480174932301694 1.18799046596881 0.514285714285714 26.2 26 2 decreased bone volume 0.00692996183703751 0.0480174932301694 1.18799046596881 0.514285714285714 26.2 26 2 infertility 3.68014120809558e-06 0.000100047554700959 1.18737364848907 0.514018691588785 26.2 26 2 abnormal vertebrae morphology 3.07700587343844e-06 8.74748812591786e-05 1.18677946651318 0.513761467889908 26.2 26 2 increased brown adipose tissue amount 0.00571453091278072 0.0414428444476445 1.18620669650038 0.513513513513513 26.2 26 2 malocclusion 0.00571453091278072 0.0414428444476445 1.18620669650038 0.513513513513513 26.2 26 2 abnormal branching of the mammary ductal tree 0.00571453091278072 0.0414428444476445 1.18620669650038 0.513513513513513 26.2 26 2 increased erythroid progenitor cell number 0.00571453091278072 0.0414428444476445 1.18620669650038 0.513513513513513 26.2 26 2 abnormal social investigation 6.63392299278305e-05 0.00116621084413766 1.18386549907308 0.5125 26.2 26 2 abnormal mammary gland development 0.00389657011170902 0.0311708643263416 1.18316123643235 0.51219512195122 26.2 26 2 short humerus 0.00389657011170902 0.0311708643263416 1.18316123643235 0.51219512195122 26.2 26 2 short ulna 0.00389657011170902 0.0311708643263416 1.18316123643235 0.51219512195122 26.2 26 2 increased oxygen consumption 3.85098344014093e-05 0.000742583047081438 1.18185098035656 0.511627906976744 26.2 26 2 abnormal vasculogenesis 0.00322155746438544 0.0273502532172654 1.18185098035656 0.511627906976744 26.2 26 2 delayed endochondral bone ossification 0.00322155746438544 0.0273502532172654 1.18185098035656 0.511627906976744 26.2 26 2 abnormal spleen morphology 6.03838324652593e-09 3.39067109602518e-07 1.18154224185595 0.511494252873563 26.2 26 2 trabecula carnea hypoplasia 0.00266541844016599 0.023387048923855 1.18065719148752 0.511111111111111 26.2 26 2 cardiomyopathy 0.00266541844016599 0.023387048923855 1.18065719148752 0.511111111111111 26.2 26 2 small testis 3.00724482764958e-13 3.83616487629658e-11 1.1800992249509 0.510869565217391 26.2 26 2 abnormal innervation 0.00220676549652344 0.02003404807519 1.17956500167115 0.51063829787234 26.2 26 2 neuron degeneration 0.00220676549652344 0.02003404807519 1.17956500167115 0.51063829787234 26.2 26 2 abnormal liver physiology 1.08851632074429e-05 0.000251877613753621 1.17809054541907 0.51 26.2 26 2 distended abdomen 0.0015153944150067 0.0150110146943997 1.17763760787757 0.509803921568627 26.2 26 2 abnormal mesoderm development 0.00125680258532679 0.0129721843609974 1.17678300874268 0.509433962264151 26.2 26 2 increased circulating bilirubin level 0.00125680258532679 0.0129721843609974 1.17678300874268 0.509433962264151 26.2 26 2 abnormal embryo turning 0.00104285626239054 0.0112787171856368 1.17599056227215 0.509090909090909 26.2 26 2 decreased brain weight 0.00086573208400843 0.00946597168778448 1.17525372608025 0.508771929824561 26.2 26 2 decreased susceptibility to hepatic steatosis 0.000496531224794809 0.00606610939729968 1.17332391700623 0.507936507936508 26.2 26 2 decreased circulating HDL cholesterol level 8.84465560071985e-07 2.83884913636008e-05 1.1730374609718 0.5078125 26.2 26 2 postnatal lethality, complete penetrance 1.80890974223894e-17 3.46127921832259e-15 1.17294395459787 0.507772020725389 26.2 26 2 decreased spleen weight 0.000285706878540395 0.0037702698162824 1.1717297269016 0.507246376811594 26.2 26 2 delayed bone ossification 0.000164846392072142 0.0024702132546955 1.17039060721371 0.506666666666667 26.2 26 2 abnormal neurocranium morphology 0.000164846392072142 0.0024702132546955 1.17039060721371 0.506666666666667 26.2 26 2 spleen hyperplasia 0.000164846392072142 0.0024702132546955 1.17039060721371 0.506666666666667 26.2 26 2 decreased food intake 0.000114398542379629 0.00181252467623775 1.16961086663595 0.506329113924051 26.2 26 2 increased exploration in new environment 9.53332921439051e-05 0.00157088021107844 1.16924987562773 0.506172839506173 26.2 26 2 abnormal skeleton development 9.53332921439051e-05 0.00157088021107844 1.16924987562773 0.506172839506173 26.2 26 2 short limbs 5.52424909468692e-05 0.00099938688167518 1.16826648632948 0.505747126436782 26.2 26 2 abnormal spermatogenesis 6.06572316675862e-09 3.39067109602518e-07 1.16754497787695 0.505434782608696 26.2 26 2 lethargy 3.20663163649417e-05 0.000640682425363795 1.16740998597293 0.505376344086022 26.2 26 2 abnormal retina morphology 6.05566361274677e-10 4.30384663905931e-08 1.16599064252494 0.504761904761905 26.2 26 2 abnormal embryonic tissue morphology 2.52234655290523e-07 9.216014515361e-06 1.16284781060439 0.503401360544218 26.2 26 2 respiratory failure 1.76588826029223e-07 6.70633137019379e-06 1.16263967604011 0.503311258278146 26.2 26 2 abnormal kidney morphology 2.08777886318082e-08 9.98721138877365e-07 1.16159067783617 0.502857142857143 26.2 26 2 impaired glucose tolerance 4.97366909095672e-11 4.2662075392258e-09 1.15499073080301 0.5 26.2 26 2 abnormal seminiferous tubule morphology 4.2538561812556e-07 1.490347500123e-05 1.15499073080301 0.5 26.2 26 2 thin ventricular wall 6.53267513532192e-05 0.00115432132679251 1.15499073080301 0.5 26.2 26 2 decreased insulin secretion 6.53267513532192e-05 0.00115432132679251 1.15499073080301 0.5 26.2 26 2 increased T cell number 7.83493065998264e-05 0.0013348897271717 1.15499073080301 0.5 26.2 26 2 arrest of spermatogenesis 0.000112769821128794 0.00179817262857613 1.15499073080301 0.5 26.2 26 2 absent gastric milk in neonates 0.000195062444978526 0.0028542225404946 1.15499073080301 0.5 26.2 26 2 domed cranium 0.000406542400646265 0.00512037580560802 1.15499073080301 0.5 26.2 26 2 abnormal vascular development 0.000588019908097372 0.00703580546155089 1.15499073080301 0.5 26.2 26 2 decreased caudal vertebrae number 0.000707570030170022 0.00801858974964888 1.15499073080301 0.5 26.2 26 2 glomerulosclerosis 0.00123584204289066 0.0128895475123292 1.15499073080301 0.5 26.2 26 2 neurodegeneration 0.00179652863611261 0.0168002442944741 1.15499073080301 0.5 26.2 26 2 decreased respiratory quotient 0.00261730153695923 0.0230870126708726 1.15499073080301 0.5 26.2 26 2 abnormal muscle morphology 0.00560003938897833 0.0412133076333834 1.15499073080301 0.5 26.2 26 2 decreased hair follicle number 0.00823282467499925 0.0540154520662669 1.15499073080301 0.5 26.2 26 2 incomplete somite formation 0.00823282467499925 0.0540154520662669 1.15499073080301 0.5 26.2 26 2 abnormal retinal outer nuclear layer morphology 0.00823282467499925 0.0540154520662669 1.15499073080301 0.5 26.2 26 2 failure of primitive streak formation 0.0147984760930695 0.082354733583995 1.15499073080301 0.5 26.2 26 2 abnormal spongiotrophoblast layer morphology 0.0147984760930695 0.082354733583995 1.15499073080301 0.5 26.2 26 2 abnormal spleen marginal zone morphology 0.0180427988164891 0.0966547929675991 1.15499073080301 0.5 26.2 26 2 abnormal circulating cholesterol level 0.0220352014578101 0.112551465351751 1.15499073080301 0.5 26.2 26 2 myoclonus 0.0220352014578101 0.112551465351751 1.15499073080301 0.5 26.2 26 2 shortened head 0.0220352014578101 0.112551465351751 1.15499073080301 0.5 26.2 26 2 abnormal jaw morphology 0.0220352014578101 0.112551465351751 1.15499073080301 0.5 26.2 26 2 abnormal retinal inner nuclear layer morphology 0.0220352014578101 0.112551465351751 1.15499073080301 0.5 26.2 26 2 corneal vascularization 0.0220352014578101 0.112551465351751 1.15499073080301 0.5 26.2 26 2 prolonged QRS complex duration 0.0220352014578101 0.112551465351751 1.15499073080301 0.5 26.2 26 2 abnormal tectorial membrane morphology 0.0269622782952306 0.126765307330344 1.15499073080301 0.5 26.2 26 2 increased thymocyte apoptosis 0.0269622782952306 0.126765307330344 1.15499073080301 0.5 26.2 26 2 abnormal digestive system morphology 0.0330632390905216 0.140830149379576 1.15499073080301 0.5 26.2 26 2 abnormal adrenal gland morphology 0.0330632390905216 0.140830149379576 1.15499073080301 0.5 26.2 26 2 ocular hypertelorism 0.0330632390905216 0.140830149379576 1.15499073080301 0.5 26.2 26 2 hemolytic anemia 0.0330632390905216 0.140830149379576 1.15499073080301 0.5 26.2 26 2 blindness 0.0330632390905216 0.140830149379576 1.15499073080301 0.5 26.2 26 2 decreased fatty acid level 0.0330632390905216 0.140830149379576 1.15499073080301 0.5 26.2 26 2 abnormal truncus arteriosus septation 0.0330632390905216 0.140830149379576 1.15499073080301 0.5 26.2 26 2 abnormal abdominal fat pad morphology 0.0406477302509495 0.167958852158201 1.15499073080301 0.5 26.2 26 2 abnormal facial nerve morphology 0.0406477302509495 0.167958852158201 1.15499073080301 0.5 26.2 26 2 aphakia 0.0406477302509495 0.167958852158201 1.15499073080301 0.5 26.2 26 2 abnormal female reproductive system physiology 0.0406477302509495 0.167958852158201 1.15499073080301 0.5 26.2 26 2 abnormal blood-brain barrier function 0.0406477302509495 0.167958852158201 1.15499073080301 0.5 26.2 26 2 pulmonary vascular congestion 0.0406477302509495 0.167958852158201 1.15499073080301 0.5 26.2 26 2 rough coat 0.0406477302509495 0.167958852158201 1.15499073080301 0.5 26.2 26 2 increased adenoma incidence 0.0406477302509495 0.167958852158201 1.15499073080301 0.5 26.2 26 2 abnormal pericardium morphology 0.0501213832953322 0.199642819771239 1.15499073080301 0.5 26.2 26 2 abnormal hair texture 0.0501213832953322 0.199642819771239 1.15499073080301 0.5 26.2 26 2 abnormal fibula morphology 0.0501213832953322 0.199642819771239 1.15499073080301 0.5 26.2 26 2 abnormal lens epithelium morphology 0.0501213832953322 0.199642819771239 1.15499073080301 0.5 26.2 26 2 abnormal heart right ventricle morphology 0.0501213832953322 0.199642819771239 1.15499073080301 0.5 26.2 26 2 abnormal postnatal subventricular zone morphology 0.0501213832953322 0.199642819771239 1.15499073080301 0.5 26.2 26 2 abnormal tympanic ring morphology 0.0770852146896844 0.271599818046161 1.15499073080301 0.5 26.2 26 2 failure of tooth eruption 0.0770852146896844 0.271599818046161 1.15499073080301 0.5 26.2 26 2 vasculature congestion 0.0770852146896844 0.271599818046161 1.15499073080301 0.5 26.2 26 2 abnormal olfaction 0.0770852146896844 0.271599818046161 1.15499073080301 0.5 26.2 26 2 blepharitis 0.0770852146896844 0.271599818046161 1.15499073080301 0.5 26.2 26 2 decreased creatinine clearance 0.0770852146896844 0.271599818046161 1.15499073080301 0.5 26.2 26 2 kidney degeneration 0.0770852146896844 0.271599818046161 1.15499073080301 0.5 26.2 26 2 absent atrioventricular cushions 0.0963218852955561 0.282634890183977 1.15499073080301 0.5 26.2 26 2 megacephaly 0.0963218852955561 0.282634890183977 1.15499073080301 0.5 26.2 26 2 irregularly shaped pupil 0.0963218852955561 0.282634890183977 1.15499073080301 0.5 26.2 26 2 absent otoliths 0.0963218852955561 0.282634890183977 1.15499073080301 0.5 26.2 26 2 decreased coping response 0.0963218852955561 0.282634890183977 1.15499073080301 0.5 26.2 26 2 abnormal ventral body wall morphology 0.0963218852955561 0.282634890183977 1.15499073080301 0.5 26.2 26 2 abnormal imprinting 0.0963218852955561 0.282634890183977 1.15499073080301 0.5 26.2 26 2 skeletal muscle necrosis 0.0963218852955561 0.282634890183977 1.15499073080301 0.5 26.2 26 2 abnormal viscerocranium morphology 0.0963218852955561 0.282634890183977 1.15499073080301 0.5 26.2 26 2 decreased tongue size 0.0963218852955561 0.282634890183977 1.15499073080301 0.5 26.2 26 2 decreased response to antigen 0.0963218852955561 0.282634890183977 1.15499073080301 0.5 26.2 26 2 abnormal adipose tissue distribution 0.121192179434289 0.341217369940909 1.15499073080301 0.5 26.2 26 2 abnormal rectum morphology 0.121192179434289 0.341217369940909 1.15499073080301 0.5 26.2 26 2 absent optic nerve 0.121192179434289 0.341217369940909 1.15499073080301 0.5 26.2 26 2 abnormal pilomotor reflex 0.121192179434289 0.341217369940909 1.15499073080301 0.5 26.2 26 2 abnormal tracheal ciliated epithelium morphology 0.121192179434289 0.341217369940909 1.15499073080301 0.5 26.2 26 2 loss of dopaminergic neurons 0.121192179434289 0.341217369940909 1.15499073080301 0.5 26.2 26 2 delayed somite formation 0.121192179434289 0.341217369940909 1.15499073080301 0.5 26.2 26 2 abnormal nucleotide metabolism 0.121192179434289 0.341217369940909 1.15499073080301 0.5 26.2 26 2 vestibular saccular macula degeneration 0.121192179434289 0.341217369940909 1.15499073080301 0.5 26.2 26 2 stria vascularis degeneration 0.121192179434289 0.341217369940909 1.15499073080301 0.5 26.2 26 2 abnormal cochlear outer hair cell physiology 0.121192179434289 0.341217369940909 1.15499073080301 0.5 26.2 26 2 abnormal somatic nervous system physiology 0.121192179434289 0.341217369940909 1.15499073080301 0.5 26.2 26 2 reduced cerebellar foliation 0.121192179434289 0.341217369940909 1.15499073080301 0.5 26.2 26 2 abnormal aorta elastic tissue morphology 0.121192179434289 0.341217369940909 1.15499073080301 0.5 26.2 26 2 increased skeletal muscle glycogen level 0.121192179434289 0.341217369940909 1.15499073080301 0.5 26.2 26 2 prenatal growth retardation 0.121192179434289 0.341217369940909 1.15499073080301 0.5 26.2 26 2 abnormal respiratory motile cilium morphology 0.121192179434289 0.341217369940909 1.15499073080301 0.5 26.2 26 2 abnormal colon goblet cell morphology 0.121192179434289 0.341217369940909 1.15499073080301 0.5 26.2 26 2 increased cranium width 0.153889729765483 0.407234790203871 1.15499073080301 0.5 26.2 26 2 small petrosal ganglion 0.153889729765483 0.407234790203871 1.15499073080301 0.5 26.2 26 2 abnormal epidermis suprabasal layer morphology 0.153889729765483 0.407234790203871 1.15499073080301 0.5 26.2 26 2 absent trophoblast giant cells 0.153889729765483 0.407234790203871 1.15499073080301 0.5 26.2 26 2 abnormal pituitary secretion 0.153889729765483 0.407234790203871 1.15499073080301 0.5 26.2 26 2 rhinitis 0.153889729765483 0.407234790203871 1.15499073080301 0.5 26.2 26 2 abnormal gland morphology 0.153889729765483 0.407234790203871 1.15499073080301 0.5 26.2 26 2 abnormal neuron specification 0.153889729765483 0.407234790203871 1.15499073080301 0.5 26.2 26 2 abnormal primordial germ cell migration 0.153889729765483 0.407234790203871 1.15499073080301 0.5 26.2 26 2 abnormal pillar cell morphology 0.153889729765483 0.407234790203871 1.15499073080301 0.5 26.2 26 2 abnormal gas homeostasis 0.153889729765483 0.407234790203871 1.15499073080301 0.5 26.2 26 2 abnormal plasma membrane morphology 0.153889729765483 0.407234790203871 1.15499073080301 0.5 26.2 26 2 abnormal utricular macula morphology 0.153889729765483 0.407234790203871 1.15499073080301 0.5 26.2 26 2 abnormal respiratory conducting tube morphology 0.153889729765483 0.407234790203871 1.15499073080301 0.5 26.2 26 2 decreased cochlear inner hair cell number 0.153889729765483 0.407234790203871 1.15499073080301 0.5 26.2 26 2 ascites 0.153889729765483 0.407234790203871 1.15499073080301 0.5 26.2 26 2 increased susceptibility to atherosclerosis 0.153889729765483 0.407234790203871 1.15499073080301 0.5 26.2 26 2 vascular smooth muscle hyperplasia 0.153889729765483 0.407234790203871 1.15499073080301 0.5 26.2 26 2 protruding tongue 0.153889729765483 0.407234790203871 1.15499073080301 0.5 26.2 26 2 abnormal cerebellar granule cell migration 0.153889729765483 0.407234790203871 1.15499073080301 0.5 26.2 26 2 increased serotonin level 0.153889729765483 0.407234790203871 1.15499073080301 0.5 26.2 26 2 umbilical hernia 0.153889729765483 0.407234790203871 1.15499073080301 0.5 26.2 26 2 acanthocytosis 0.153889729765483 0.407234790203871 1.15499073080301 0.5 26.2 26 2 aorta stenosis 0.153889729765483 0.407234790203871 1.15499073080301 0.5 26.2 26 2 abnormal left subclavian artery morphology 0.153889729765483 0.407234790203871 1.15499073080301 0.5 26.2 26 2 abnormal pulmonary interalveolar septum morphology 0.153889729765483 0.407234790203871 1.15499073080301 0.5 26.2 26 2 decreased trabecular bone connectivity density 0.153889729765483 0.407234790203871 1.15499073080301 0.5 26.2 26 2 decreased macrophage cytokine production 0.153889729765483 0.407234790203871 1.15499073080301 0.5 26.2 26 2 increased fatty acid oxidation 0.153889729765483 0.407234790203871 1.15499073080301 0.5 26.2 26 2 abnormal limb bone morphology 0.00999777973970492 0.0624861233731558 1.154990730803 0.5 26.2 26 2 short radius 0.00999777973970492 0.0624861233731558 1.154990730803 0.5 26.2 26 2 lowered ear position 0.0620235580938353 0.233586072306458 1.154990730803 0.5 26.2 26 2 abnormal heart shape 0.0620235580938353 0.233586072306458 1.154990730803 0.5 26.2 26 2 abnormal mammary gland morphology 0.0620235580938353 0.233586072306458 1.154990730803 0.5 26.2 26 2 blepharoptosis 0.0620235580938353 0.233586072306458 1.154990730803 0.5 26.2 26 2 abnormal white adipose tissue morphology 0.0620235580938353 0.233586072306458 1.154990730803 0.5 26.2 26 2 abnormal metacarpal bone morphology 0.0620235580938353 0.233586072306458 1.154990730803 0.5 26.2 26 2 absent allantois 0.0620235580938353 0.233586072306458 1.154990730803 0.5 26.2 26 2 increased circulating renin level 0.0620235580938353 0.233586072306458 1.154990730803 0.5 26.2 26 2 decreased activity of thyroid 0.0620235580938353 0.233586072306458 1.154990730803 0.5 26.2 26 2 decreased pulmonary respiratory rate 0.0620235580938353 0.233586072306458 1.154990730803 0.5 26.2 26 2 abnormal pregnancy 0.0620235580938353 0.233586072306458 1.154990730803 0.5 26.2 26 2 small thoracic cage 0.0620235580938353 0.233586072306458 1.154990730803 0.5 26.2 26 2 decreased anxiety-related response 5.10514397031066e-06 0.000132974299750238 1.14560056225989 0.495934959349593 26.2 26 2 decreased bone mineral content 4.01060881491234e-09 2.33640137415313e-07 1.14388505069913 0.495192307692308 26.2 26 2 decreased rib number 0.000109907587813236 0.00178107573084968 1.1420133068614 0.49438202247191 26.2 26 2 decreased bone marrow cell number 0.000474660312655671 0.00587421655587553 1.13916893997009 0.493150684931507 26.2 26 2 decreased percent body fat/body weight 0.000474660312655671 0.00587421655587553 1.13916893997009 0.493150684931507 26.2 26 2 decreased white adipose tissue amount 0.000825454809336701 0.00914618636180421 1.13775206317908 0.492537313432836 26.2 26 2 abnormal platelet physiology 0.00252328413934461 0.0224567774476555 1.13399089933386 0.490909090909091 26.2 26 2 abnormal gastrulation 0.00367682761575974 0.0301354487453125 1.13234385372844 0.490196078431373 26.2 26 2 abnormal gluconeogenesis 0.00367682761575974 0.0301354487453125 1.13234385372844 0.490196078431373 26.2 26 2 abnormal craniofacial development 0.0044425339012145 0.0340136661231006 1.13141949139886 0.489795918367347 26.2 26 2 increased circulating triglyceride level 1.64061928744961e-06 4.97687863113526e-05 1.13109437085536 0.489655172413793 26.2 26 2 hepatic necrosis 0.00537138881994188 0.0398845662376281 1.13041645993486 0.48936170212766 26.2 26 2 reduced male fertility 2.57148138435848e-09 1.57939751693623e-07 1.12955040633598 0.488986784140969 26.2 26 2 abnormal myocardial trabeculae morphology 0.00649929064979038 0.0458637886279534 1.12932427011849 0.488888888888889 26.2 26 2 albuminuria 0.00649929064979038 0.0458637886279534 1.12932427011849 0.488888888888889 26.2 26 2 hyperglycemia 0.000182974625347323 0.00269319160089625 1.12874094146657 0.488636363636364 26.2 26 2 abnormal double-strand DNA break repair 0.00787040849881705 0.0532724929001563 1.12813048124945 0.488372093023256 26.2 26 2 scaly skin 0.00953921841767407 0.0604555562139217 1.12682022517366 0.48780487804878 26.2 26 2 hemopericardium 0.00953921841767407 0.0604555562139217 1.12682022517366 0.48780487804878 26.2 26 2 abnormal heart looping 0.0115730902346457 0.0673670256870145 1.12537558385934 0.487179487179487 26.2 26 2 abnormal iris morphology 0.0115730902346457 0.0673670256870145 1.12537558385934 0.487179487179487 26.2 26 2 enlarged heart 2.47752360253819e-09 1.54070999032844e-07 1.12512028086844 0.487068965517241 26.2 26 2 abnormal axial skeleton morphology 0.000547419856926701 0.0066263109202198 1.12459623788714 0.486842105263158 26.2 26 2 abnormal hepatocyte morphology 3.44423538814246e-05 0.000677275535810622 1.12377476510563 0.486486486486487 26.2 26 2 abnormal intestine morphology 0.000657710707917653 0.00762729783657418 1.12377476510563 0.486486486486487 26.2 26 2 abnormal pancreatic beta cell physiology 0.0140555944178438 0.0788349292319872 1.12377476510563 0.486486486486487 26.2 26 2 increased trabecular bone volume 0.0140555944178438 0.0788349292319872 1.12377476510563 0.486486486486487 26.2 26 2 abnormal renal glomerulus morphology 4.12331265092179e-05 0.000785957104917084 1.12320199509283 0.486238532110092 26.2 26 2 thick pulmonary interalveolar septum 0.0170907594233841 0.0922196617476526 1.1219909956372 0.485714285714286 26.2 26 2 ovary cysts 0.0170907594233841 0.0922196617476526 1.1219909956372 0.485714285714286 26.2 26 2 increased circulating serum albumin level 0.0170907594233841 0.0922196617476526 1.1219909956372 0.485714285714286 26.2 26 2 decreased triglyceride level 0.0170907594233841 0.0922196617476526 1.1219909956372 0.485714285714286 26.2 26 2 decreased mean corpuscular hemoglobin 0.0011428268653482 0.0121746545077244 1.12102041519115 0.485294117647059 26.2 26 2 hemorrhage 2.83821820367147e-09 1.70122115220067e-07 1.1205867515876 0.485106382978723 26.2 26 2 abnormal tail morphology 0.00137485272459549 0.0137623587622989 1.11999101168776 0.484848484848485 26.2 26 2 abnormal ovarian folliculogenesis 0.0208085976858489 0.108287419965584 1.11999101168776 0.484848484848485 26.2 26 2 dilated heart atrium 0.0208085976858489 0.108287419965584 1.11999101168776 0.484848484848485 26.2 26 2 abnormal heart morphology 4.03880438547074e-09 2.33640137415313e-07 1.11999101168776 0.484848484848485 26.2 26 2 abnormal osteoclast physiology 0.0016546028671455 0.0159897218485844 1.11889727046541 0.484375 26.2 26 2 abnormal cranial ganglia morphology 0.0253723465780405 0.126765307330344 1.11773296529323 0.483870967741935 26.2 26 2 decreased double-negative T cell number 0.0253723465780405 0.126765307330344 1.11773296529323 0.483870967741935 26.2 26 2 anemia 2.35731269628355e-08 1.09604024897296e-06 1.11667350276689 0.483412322274882 26.2 26 2 muscular ventricular septal defect 0.00239936321134185 0.0216246956094668 1.11649103977624 0.483333333333333 26.2 26 2 male infertility 8.32695688304435e-18 1.80115697796285e-15 1.11595525878779 0.483101391650099 26.2 26 2 abnormal blood vessel morphology 3.67727006121621e-06 0.000100047554700959 1.11516346422359 0.482758620689655 26.2 26 2 thrombocytosis 0.00289123768287465 0.0249720615838565 1.11516346422359 0.482758620689655 26.2 26 2 aphagia 0.0309880620286056 0.136605504771673 1.11516346422359 0.482758620689655 26.2 26 2 polychromatophilia 0.0309880620286056 0.136605504771673 1.11516346422359 0.482758620689655 26.2 26 2 reduced long term potentiation 4.70765716210164e-05 0.000877175819530174 1.11374106184576 0.482142857142857 26.2 26 2 increased heart weight 6.27181613136739e-06 0.000161669871780066 1.11344430163743 0.482014388489209 26.2 26 2 decreased heart weight 0.00052029639314763 0.00631335257538893 1.11221329632882 0.481481481481481 26.2 26 2 diluted coat color 0.00420435499769609 0.0330959906859779 1.11221329632882 0.481481481481481 26.2 26 2 decreased tumor growth/size 0.00420435499769609 0.0330959906859779 1.11221329632882 0.481481481481481 26.2 26 2 abnormal long bone epiphyseal plate proliferative zone 0.00420435499769609 0.0330959906859779 1.11221329632882 0.481481481481481 26.2 26 2 thick interventricular septum 0.0379174951433153 0.159055259981445 1.11221329632882 0.481481481481481 26.2 26 2 hunched posture 0.000624473262588959 0.00727633976444515 1.11113032330416 0.481012658227848 26.2 26 2 abnormal somite development 0.000624473262588959 0.00727633976444515 1.11113032330416 0.481012658227848 26.2 26 2 abnormal placenta labyrinth morphology 0.000624473262588959 0.00727633976444515 1.11113032330416 0.481012658227848 26.2 26 2 abnormal visceral yolk sac morphology 0.000624473262588959 0.00727633976444515 1.11113032330416 0.481012658227848 26.2 26 2 decreased circulating cholesterol level 2.79049867455506e-07 9.98757619130318e-06 1.1108107574936 0.480874316939891 26.2 26 2 cachexia 9.66065108659805e-05 0.00158619601174341 1.11056801038751 0.480769230769231 26.2 26 2 increased monocyte cell number 0.000138490801127083 0.00216664067801018 1.10879110157088 0.48 26.2 26 2 abnormal interventricular septum morphology 0.00612736377591163 0.0443076086993609 1.10879110157088 0.48 26.2 26 2 short stride length 0.00612736377591163 0.0443076086993609 1.10879110157088 0.48 26.2 26 2 abnormal inner ear vestibule morphology 0.0464956420737912 0.189138037054057 1.10879110157088 0.48 26.2 26 2 abnormal nest building behavior 0.0464956420737912 0.189138037054057 1.10879110157088 0.48 26.2 26 2 abnormal keratinocyte physiology 0.0464956420737912 0.189138037054057 1.10879110157088 0.48 26.2 26 2 decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 0.0464956420737912 0.189138037054057 1.10879110157088 0.48 26.2 26 2 enlarged spleen 1.90975858265566e-10 1.48453889823623e-08 1.10686611701955 0.479166666666667 26.2 26 2 abnormal skeletal muscle fiber morphology 0.00129918805241742 0.0133542573569765 1.10618830555781 0.47887323943662 26.2 26 2 abnormal circulating insulin level 0.0571551027143045 0.222493455401929 1.10477374250722 0.478260869565217 26.2 26 2 conjunctivitis 0.0571551027143045 0.222493455401929 1.10477374250722 0.478260869565217 26.2 26 2 abnormal nasal cavity morphology 0.0571551027143045 0.222493455401929 1.10477374250722 0.478260869565217 26.2 26 2 abnormal lens development 0.0571551027143045 0.222493455401929 1.10477374250722 0.478260869565217 26.2 26 2 increased spleen weight 6.38286323074558e-05 0.00114638067050394 1.1038849462542 0.47787610619469 26.2 26 2 abnormal enzyme/coenzyme activity 2.77614667809254e-06 7.98342758584415e-05 1.10349432879268 0.477707006369427 26.2 26 2 cochlear hair cell degeneration 0.0108336503617896 0.0667786585857757 1.10249115213014 0.477272727272727 26.2 26 2 increased circulating creatinine level 0.000490725448124206 0.00604296808024239 1.10127023169589 0.476744186046512 26.2 26 2 abnormal lens morphology 2.4682394882708e-05 0.000515945019081816 1.10085054029661 0.4765625 26.2 26 2 hydronephrosis 0.000588320617488476 0.00703580546155089 1.09999117219334 0.476190476190476 26.2 26 2 abnormal nervous system electrophysiology 0.000588320617488476 0.00703580546155089 1.09999117219334 0.476190476190476 26.2 26 2 skin edema 0.0131202902619429 0.0745130639876324 1.09999117219334 0.476190476190476 26.2 26 2 abnormal reproductive system morphology 0.0131202902619429 0.0745130639876324 1.09999117219334 0.476190476190476 26.2 26 2 abnormal anxiety-related response 0.0704606349869941 0.25710735821703 1.09999117219334 0.476190476190476 26.2 26 2 abnormal hematopoietic system physiology 0.0704606349869941 0.25710735821703 1.09999117219334 0.476190476190476 26.2 26 2 vascular ring 0.0704606349869941 0.25710735821703 1.09999117219334 0.476190476190476 26.2 26 2 decreased vocalization 0.0704606349869941 0.25710735821703 1.09999117219334 0.476190476190476 26.2 26 2 thrombocytopenia 8.02602804676885e-06 0.000196239809657466 1.09923255759183 0.475862068965517 26.2 26 2 head bobbing 0.0159036274026917 0.0867506358282566 1.09724119426286 0.475 26.2 26 2 perinatal lethality 0.0159036274026917 0.0867506358282566 1.09724119426286 0.475 26.2 26 2 increased macrophage cell number 0.00473980506864806 0.0354062015263125 1.09420174497127 0.473684210526316 26.2 26 2 abnormal compact bone morphology 0.0192960871864037 0.100944304681765 1.09420174497127 0.473684210526316 26.2 26 2 decreased total retina thickness 0.0192960871864037 0.100944304681765 1.09420174497127 0.473684210526316 26.2 26 2 kyphoscoliosis 0.0871594784266561 0.272054586125999 1.09420174497127 0.473684210526316 26.2 26 2 abnormal triglyceride level 0.0871594784266561 0.272054586125999 1.09420174497127 0.473684210526316 26.2 26 2 stereotypic behavior 0.0871594784266561 0.272054586125999 1.09420174497127 0.473684210526316 26.2 26 2 increased malignant tumor incidence 0.0871594784266561 0.272054586125999 1.09420174497127 0.473684210526316 26.2 26 2 decreased tumor incidence 0.0871594784266561 0.272054586125999 1.09420174497127 0.473684210526316 26.2 26 2 abnormal ear morphology 0.0871594784266561 0.272054586125999 1.09420174497127 0.473684210526316 26.2 26 2 decreased germ cell number 0.0871594784266561 0.272054586125999 1.09420174497127 0.473684210526316 26.2 26 2 increased susceptibility to ischemic brain injury 0.0871594784266561 0.272054586125999 1.09420174497127 0.473684210526316 26.2 26 2 maternal imprinting 0.0871594784266561 0.272054586125999 1.09420174497127 0.473684210526316 26.2 26 2 absent amnion 0.0871594784266561 0.272054586125999 1.09420174497127 0.473684210526316 26.2 26 2 eyelids fail to open 0.0871594784266561 0.272054586125999 1.09420174497127 0.473684210526316 26.2 26 2 decreased liver regeneration 0.0871594784266561 0.272054586125999 1.09420174497127 0.473684210526316 26.2 26 2 increased liver cholesterol level 0.0871594784266561 0.272054586125999 1.09420174497127 0.473684210526316 26.2 26 2 decreased circulating magnesium level 0.0871594784266561 0.272054586125999 1.09420174497127 0.473684210526316 26.2 26 2 thin interventricular septum 0.0871594784266561 0.272054586125999 1.09420174497127 0.473684210526316 26.2 26 2 increased body weight 5.17260800426066e-08 2.16249788413418e-06 1.09311622736713 0.473214285714286 26.2 26 2 abnormal learning/memory/conditioning 0.0057115219741491 0.0414428444476445 1.09199123639557 0.472727272727273 26.2 26 2 abnormal rostral-caudal axis patterning 0.0057115219741491 0.0414428444476445 1.09199123639557 0.472727272727273 26.2 26 2 decreased hematocrit 1.07485438953435e-05 0.00024987853214642 1.09170356747133 0.472602739726027 26.2 26 2 abnormal reflex 0.0234371096666758 0.117658547519386 1.09082457909173 0.472222222222222 26.2 26 2 abnormal coat/ hair morphology 0.00688574486337427 0.0480174932301694 1.08961389698397 0.471698113207547 26.2 26 2 no abnormal phenotype detected 2.40502756511169e-52 3.98833737881023e-49 1.08908636057275 0.471469740634006 26.2 26 2 abnormal action potential 0.00210647031657545 0.0193067656760345 1.0889912604714 0.471428571428571 26.2 26 2 abnormal retinal pigmentation 0.000659534385945152 0.00763065946529566 1.08861195317065 0.471264367816092 26.2 26 2 abnormal inhibitory postsynaptic currents 0.00252989941186541 0.0224754456679115 1.0870500995793 0.470588235294118 26.2 26 2 abnormal cued conditioning behavior 0.00830561814049111 0.0540154520662669 1.0870500995793 0.470588235294118 26.2 26 2 small lung 0.00830561814049111 0.0540154520662669 1.0870500995793 0.470588235294118 26.2 26 2 overexpanded pulmonary alveoli 0.0285002268453197 0.130440320658202 1.0870500995793 0.470588235294118 26.2 26 2 thin skin 0.0285002268453197 0.130440320658202 1.0870500995793 0.470588235294118 26.2 26 2 abnormal vision 0.0285002268453197 0.130440320658202 1.0870500995793 0.470588235294118 26.2 26 2 increased susceptibility to weight gain 0.0285002268453197 0.130440320658202 1.0870500995793 0.470588235294118 26.2 26 2 abnormal urinary bladder morphology 0.108257026765765 0.309705985140702 1.0870500995793 0.470588235294118 26.2 26 2 abnormal involuntary movement 0.108257026765765 0.309705985140702 1.0870500995793 0.470588235294118 26.2 26 2 abnormal testis development 0.108257026765765 0.309705985140702 1.0870500995793 0.470588235294118 26.2 26 2 increased circulating magnesium level 0.108257026765765 0.309705985140702 1.0870500995793 0.470588235294118 26.2 26 2 common atrium 0.108257026765765 0.309705985140702 1.0870500995793 0.470588235294118 26.2 26 2 circling 0.000790004486623423 0.00879255552785577 1.0870500995793 0.470588235294118 26.2 26 2 female infertility 5.90293667672603e-09 3.37552988123126e-07 1.08551760413816 0.469924812030075 26.2 26 2 abnormal lipid level 0.00094642447915387 0.0103255740872599 1.08541297593535 0.469879518072289 26.2 26 2 decreased circulating glucose level 2.75957936128164e-09 1.67425699053368e-07 1.08461495150676 0.469534050179211 26.2 26 2 improved glucose tolerance 5.95918132527564e-07 1.97646180621642e-05 1.08427701259058 0.469387755102041 26.2 26 2 increased circulating LDL cholesterol level 0.0100237594053575 0.0624914825083377 1.08427701259058 0.469387755102041 26.2 26 2 decreased circulating creatinine level 0.0100237594053575 0.0624914825083377 1.08427701259058 0.469387755102041 26.2 26 2 decreased circulating LDL cholesterol level 0.00365227231875815 0.0301354487453125 1.08280381012782 0.46875 26.2 26 2 abnormal heart atrium morphology 0.0347022323000738 0.146060580112409 1.08280381012782 0.46875 26.2 26 2 decreased B cell proliferation 0.0013589450897038 0.0137413654903992 1.08189005163826 0.468354430379747 26.2 26 2 abnormal myocardium layer morphology 0.0013589450897038 0.0137413654903992 1.08189005163826 0.468354430379747 26.2 26 2 decreased hemoglobin content 2.42465904166811e-05 0.000508973786172948 1.08126791819856 0.468085106382979 26.2 26 2 prenatal lethality 0.00439023756483307 0.0340136661231006 1.08047519978346 0.467741935483871 26.2 26 2 increased or absent threshold for auditory brainstem response 2.40905368981111e-09 1.51709393757092e-07 1.07905708414122 0.467128027681661 26.2 26 2 spleen hypoplasia 0.000278663247313993 0.0037442351174805 1.07799134874947 0.466666666666667 26.2 26 2 oxidative stress 0.000733643341598678 0.00820196769540095 1.07799134874947 0.466666666666667 26.2 26 2 increased erythrocyte cell number 0.00527900642302825 0.0393748979828569 1.07799134874947 0.466666666666667 26.2 26 2 increased metastatic potential 0.0423151673392074 0.173408531723688 1.07799134874947 0.466666666666667 26.2 26 2 emphysema 0.0423151673392074 0.173408531723688 1.07799134874947 0.466666666666667 26.2 26 2 abnormal cellular respiration 0.0423151673392074 0.173408531723688 1.07799134874947 0.466666666666667 26.2 26 2 abnormal fontanelle morphology 0.135135181949995 0.367175057455613 1.07799134874947 0.466666666666667 26.2 26 2 abnormal prostate gland morphology 0.135135181949995 0.367175057455613 1.07799134874947 0.466666666666667 26.2 26 2 increased airway responsiveness 0.135135181949995 0.367175057455613 1.07799134874947 0.466666666666667 26.2 26 2 altered righting response 0.135135181949995 0.367175057455613 1.07799134874947 0.466666666666667 26.2 26 2 abnormal ear development 0.135135181949995 0.367175057455613 1.07799134874947 0.466666666666667 26.2 26 2 abnormal neurotransmitter secretion 0.135135181949995 0.367175057455613 1.07799134874947 0.466666666666667 26.2 26 2 abnormal secondary palate development 0.135135181949995 0.367175057455613 1.07799134874947 0.466666666666667 26.2 26 2 ostium primum atrial septal defect 0.135135181949995 0.367175057455613 1.07799134874947 0.466666666666667 26.2 26 2 decreased B cell number 5.18630671795693e-07 1.77943971874729e-05 1.07649621511736 0.466019417475728 26.2 26 2 decreased T cell number 8.74968812320363e-06 0.000211309215596787 1.07607832062392 0.46583850931677 26.2 26 2 dermatitis 0.00634984763045071 0.0454969088407215 1.07533619764418 0.46551724137931 26.2 26 2 abnormal pulmonary alveolus morphology 0.000397676022917544 0.00504703626024179 1.0749418682721 0.465346534653465 26.2 26 2 abnormal homeostasis 0.0176854048385741 0.095221741419812 1.07440998214233 0.465116279069767 26.2 26 2 decreased liver weight 0.00280753123018639 0.0242912484698735 1.07365335539434 0.464788732394366 26.2 26 2 abnormal stria vascularis morphology 0.051682149670753 0.204041092408508 1.0724913928885 0.464285714285714 26.2 26 2 reddish skin 0.051682149670753 0.204041092408508 1.0724913928885 0.464285714285714 26.2 26 2 abnormal ovulation 0.051682149670753 0.204041092408508 1.0724913928885 0.464285714285714 26.2 26 2 straub tail 0.051682149670753 0.204041092408508 1.0724913928885 0.464285714285714 26.2 26 2 abnormal renal tubule epithelium morphology 0.051682149670753 0.204041092408508 1.0724913928885 0.464285714285714 26.2 26 2 increased food intake 0.00125678115926387 0.0129721843609974 1.0724913928885 0.464285714285714 26.2 26 2 increased total body fat amount 6.44723247228533e-05 0.00115377631473452 1.06879739268338 0.462686567164179 26.2 26 2 abnormal snout morphology 0.011075501570501 0.0668696848461683 1.066145289972 0.461538461538462 26.2 26 2 abnormal female meiosis 0.011075501570501 0.0668696848461683 1.066145289972 0.461538461538462 26.2 26 2 ventricular hypoplasia 0.0632385253125577 0.237263697910991 1.066145289972 0.461538461538462 26.2 26 2 thick skin 0.0632385253125577 0.237263697910991 1.066145289972 0.461538461538462 26.2 26 2 decreased bone resorption 0.0632385253125577 0.237263697910991 1.066145289972 0.461538461538462 26.2 26 2 abnormal renal/urinary system morphology 0.169746740711912 0.427589891160387 1.066145289972 0.461538461538462 26.2 26 2 pup cannibalization 0.169746740711912 0.427589891160387 1.066145289972 0.461538461538462 26.2 26 2 excessive scratching 0.169746740711912 0.427589891160387 1.066145289972 0.461538461538462 26.2 26 2 increased synaptic depression 0.169746740711912 0.427589891160387 1.066145289972 0.461538461538462 26.2 26 2 abnormal bile duct development 0.169746740711912 0.427589891160387 1.066145289972 0.461538461538462 26.2 26 2 absent lateral semicircular canal 0.169746740711912 0.427589891160387 1.066145289972 0.461538461538462 26.2 26 2 abnormal dopaminergic neuron morphology 0.169746740711912 0.427589891160387 1.066145289972 0.461538461538462 26.2 26 2 decreased alcohol consumption 0.169746740711912 0.427589891160387 1.066145289972 0.461538461538462 26.2 26 2 increased circulating thyroid-stimulating hormone level 0.169746740711912 0.427589891160387 1.066145289972 0.461538461538462 26.2 26 2 increased circulating thyroxine level 0.169746740711912 0.427589891160387 1.066145289972 0.461538461538462 26.2 26 2 decreased cardiac stroke volume 0.169746740711912 0.427589891160387 1.066145289972 0.461538461538462 26.2 26 2 abnormal B cell differentiation 0.000968304926578481 0.0105411750759911 1.066145289972 0.461538461538462 26.2 26 2 enlarged liver 0.000624522026013684 0.00727633976444515 1.06259147233876 0.46 26.2 26 2 testicular atrophy 0.0133429112378484 0.0751541588047679 1.06259147233876 0.46 26.2 26 2 increased granulocyte number 0.00308882400719219 0.0264036072779745 1.06134283371087 0.459459459459459 26.2 26 2 increased white adipose tissue amount 0.0314113976281831 0.136605504771673 1.06134283371087 0.459459459459459 26.2 26 2 increased circulating phosphate level 0.0314113976281831 0.136605504771673 1.06134283371087 0.459459459459459 26.2 26 2 abnormal hair follicle development 0.0314113976281831 0.136605504771673 1.06134283371087 0.459459459459459 26.2 26 2 skin inflammation 0.0314113976281831 0.136605504771673 1.06134283371087 0.459459459459459 26.2 26 2 abnormal respiratory electron transport chain 0.0314113976281831 0.136605504771673 1.06134283371087 0.459459459459459 26.2 26 2 abnormal male meiosis 0.00698488101292915 0.0483307135456502 1.06031935942571 0.459016393442623 26.2 26 2 abnormal phalanx morphology 0.0160817117340112 0.0872481089168003 1.05874150323609 0.458333333333333 26.2 26 2 abnormal vasodilation 0.0775405257805822 0.272054586125999 1.05874150323609 0.458333333333333 26.2 26 2 apnea 0.0775405257805822 0.272054586125999 1.05874150323609 0.458333333333333 26.2 26 2 abnormal lung saccule morphology 0.0775405257805822 0.272054586125999 1.05874150323609 0.458333333333333 26.2 26 2 holoprosencephaly 0.0381081994111605 0.159720549343322 1.0559915253056 0.457142857142857 26.2 26 2 abnormal inner ear morphology 0.019391890245976 0.101232585491847 1.05455675421144 0.456521739130435 26.2 26 2 abnormal lymphocyte physiology 0.019391890245976 0.101232585491847 1.05455675421144 0.456521739130435 26.2 26 2 increased circulating insulin level 2.76146724040377e-05 0.000570053922033559 1.05392904185774 0.45625 26.2 26 2 absent vitelline blood vessels 0.0100735927474675 0.0626451548983134 1.05367575441678 0.456140350877193 26.2 26 2 decreased circulating alanine transaminase level 0.00530520386576466 0.0395110617248192 1.05307978396745 0.455882352941176 26.2 26 2 teratozoospermia 0.00180362394536319 0.0168349514600035 1.04999157345728 0.454545454545455 26.2 26 2 obese 0.00337235308677026 0.0282925069252648 1.04999157345728 0.454545454545455 26.2 26 2 abnormal skin morphology 0.00635488181129544 0.0454969088407215 1.04999157345728 0.454545454545455 26.2 26 2 abnormal basisphenoid bone morphology 0.095304722267031 0.281723703671111 1.04999157345728 0.454545454545455 26.2 26 2 abnormal enterocyte morphology 0.095304722267031 0.281723703671111 1.04999157345728 0.454545454545455 26.2 26 2 increased skin papilloma incidence 0.095304722267031 0.281723703671111 1.04999157345728 0.454545454545455 26.2 26 2 increased myocardial infarction size 0.095304722267031 0.281723703671111 1.04999157345728 0.454545454545455 26.2 26 2 abnormal tracheal cartilage morphology 0.095304722267031 0.281723703671111 1.04999157345728 0.454545454545455 26.2 26 2 decreased cardiac output 0.095304722267031 0.281723703671111 1.04999157345728 0.454545454545455 26.2 26 2 abnormal retinal outer plexiform layer morphology 0.095304722267031 0.281723703671111 1.04999157345728 0.454545454545455 26.2 26 2 decreased circulating estradiol level 0.095304722267031 0.281723703671111 1.04999157345728 0.454545454545455 26.2 26 2 abnormal mesenteric lymph node morphology 0.095304722267031 0.281723703671111 1.04999157345728 0.454545454545455 26.2 26 2 abnormal temporal bone morphology 0.095304722267031 0.281723703671111 1.04999157345728 0.454545454545455 26.2 26 2 increased mast cell number 0.214954999738266 0.49924607052318 1.04999157345728 0.454545454545455 26.2 26 2 abnormal awl hair morphology 0.214954999738266 0.49924607052318 1.04999157345728 0.454545454545455 26.2 26 2 delayed hepatic development 0.214954999738266 0.49924607052318 1.04999157345728 0.454545454545455 26.2 26 2 abnormal glossopharyngeal ganglion morphology 0.214954999738266 0.49924607052318 1.04999157345728 0.454545454545455 26.2 26 2 abnormal eye distance/ position 0.214954999738266 0.49924607052318 1.04999157345728 0.454545454545455 26.2 26 2 impaired myelopoiesis 0.214954999738266 0.49924607052318 1.04999157345728 0.454545454545455 26.2 26 2 allodynia 0.214954999738266 0.49924607052318 1.04999157345728 0.454545454545455 26.2 26 2 abnormal ureter development 0.214954999738266 0.49924607052318 1.04999157345728 0.454545454545455 26.2 26 2 aberrant origin of the right subclavian artery 0.214954999738266 0.49924607052318 1.04999157345728 0.454545454545455 26.2 26 2 abnormal phrenic nerve innervation pattern to diaphragm 0.214954999738266 0.49924607052318 1.04999157345728 0.454545454545455 26.2 26 2 abnormal lung morphology 0.000338594800641723 0.00438674253435566 1.04822688173718 0.453781512605042 26.2 26 2 abnormal tooth morphology 0.0076131532389909 0.0522370125624978 1.04671034979022 0.453125 26.2 26 2 abnormal eyelid morphology 0.0562680785542861 0.219728171748488 1.04321743427368 0.451612903225806 26.2 26 2 abnormal nose morphology 0.0562680785542861 0.219728171748488 1.04321743427368 0.451612903225806 26.2 26 2 decreased bone mineral density 1.95396291968131e-07 7.30899663565003e-06 1.04209689997264 0.451127819548872 26.2 26 2 cochlear inner hair cell degeneration 0.0174806877106775 0.0942214749302498 1.04175634543016 0.450980392156863 26.2 26 2 abnormal glucose homeostasis 1.63668732207906e-05 0.000363505331577826 1.040760878306 0.450549450549451 26.2 26 2 decreased heart rate 0.00125342085998485 0.0129721843609974 1.0394916577227 0.45 26.2 26 2 abnormal retinal pigment epithelium morphology 0.00365683900474167 0.0301354487453125 1.0394916577227 0.45 26.2 26 2 abnormal skin pigmentation 0.0341075755056872 0.143801006898978 1.0394916577227 0.45 26.2 26 2 increased urine glucose level 0.117463374443194 0.334505030254659 1.0394916577227 0.45 26.2 26 2 abnormal induced retinal neovascularization 0.117463374443194 0.334505030254659 1.0394916577227 0.45 26.2 26 2 abnormal sperm mitochondrial sheath morphology 0.117463374443194 0.334505030254659 1.0394916577227 0.45 26.2 26 2 nuclear cataracts 0.117463374443194 0.334505030254659 1.0394916577227 0.45 26.2 26 2 microcephaly 0.00688595612853647 0.0480174932301694 1.03781775811285 0.449275362318841 26.2 26 2 hyperkeratosis 0.00688595612853647 0.0480174932301694 1.03781775811285 0.449275362318841 26.2 26 2 abnormal coat appearance 0.00688595612853647 0.0480174932301694 1.03781775811285 0.449275362318841 26.2 26 2 organ of Corti degeneration 0.0210178210388403 0.109261922328349 1.03713453378229 0.448979591836735 26.2 26 2 increased urine protein level 0.00436326324609076 0.0340136661231006 1.03653014302834 0.448717948717949 26.2 26 2 decreased litter size 1.49039133934349e-07 5.79273196346396e-06 1.0357923991543 0.448398576512456 26.2 26 2 abnormal middle ear morphology 0.0684960958799979 0.252607914753884 1.03550893106476 0.448275862068966 26.2 26 2 lordosis 0.0684960958799979 0.252607914753884 1.03550893106476 0.448275862068966 26.2 26 2 enlarged epididymis 0.0684960958799979 0.252607914753884 1.03550893106476 0.448275862068966 26.2 26 2 decreased threshold for auditory brainstem response 0.0412190298905759 0.170037042873644 1.03341275913953 0.447368421052632 26.2 26 2 abnormal tibia morphology 0.0252779179161431 0.126644150687625 1.03211937646226 0.446808510638298 26.2 26 2 short mandible 0.0157000409615563 0.0867506358282566 1.03124172393125 0.446428571428571 26.2 26 2 increased anxiety-related response 0.000232606723450751 0.00324150826097335 1.03035144330628 0.446043165467626 26.2 26 2 pale liver 0.00621093063654277 0.0448467052493473 1.03012686801349 0.445945945945946 26.2 26 2 deafness 0.00190844934663645 0.0176806992542203 1.02665842738045 0.444444444444444 26.2 26 2 abnormal small intestine morphology 0.0188193652960063 0.0998051801471988 1.02665842738045 0.444444444444444 26.2 26 2 abnormal ovarian follicle morphology 0.0304103883367788 0.136176131391066 1.02665842738045 0.444444444444444 26.2 26 2 abnormal trigeminal ganglion morphology 0.0834953494479514 0.272054586125999 1.02665842738045 0.444444444444444 26.2 26 2 abnormal heart left ventricle morphology 0.00740947067979156 0.0511263753563981 1.02665842738045 0.444444444444444 26.2 26 2 impaired wound healing 0.049845071206748 0.199500586688312 1.02665842738045 0.444444444444444 26.2 26 2 abnormal retinal blood vessel morphology 0.049845071206748 0.199500586688312 1.02665842738045 0.444444444444444 26.2 26 2 abnormal megakaryocyte differentiation 0.145243801703309 0.392071575406382 1.02665842738045 0.444444444444444 26.2 26 2 abnormal radius morphology 0.145243801703309 0.392071575406382 1.02665842738045 0.444444444444444 26.2 26 2 abnormal thymus medulla morphology 0.145243801703309 0.392071575406382 1.02665842738045 0.444444444444444 26.2 26 2 abnormal Peyer's patch follicle morphology 0.145243801703309 0.392071575406382 1.02665842738045 0.444444444444444 26.2 26 2 abnormal body wall morphology 0.145243801703309 0.392071575406382 1.02665842738045 0.444444444444444 26.2 26 2 long tibia 0.145243801703309 0.392071575406382 1.02665842738045 0.444444444444444 26.2 26 2 abnormal neutrophil morphology 0.145243801703309 0.392071575406382 1.02665842738045 0.444444444444444 26.2 26 2 abnormal glycogen homeostasis 0.145243801703309 0.392071575406382 1.02665842738045 0.444444444444444 26.2 26 2 atrioventricular block 0.145243801703309 0.392071575406382 1.02665842738045 0.444444444444444 26.2 26 2 increased adipocyte glucose uptake 0.145243801703309 0.392071575406382 1.02665842738045 0.444444444444444 26.2 26 2 increased inflammatory response 0.00269248229956652 0.0235829215499004 1.02125496197318 0.442105263157895 26.2 26 2 abnormal male reproductive system morphology 0.0365958230063759 0.153640691524658 1.02068948303521 0.441860465116279 26.2 26 2 decreased oxygen consumption 0.0365958230063759 0.153640691524658 1.02068948303521 0.441860465116279 26.2 26 2 abnormal retinal photoreceptor morphology 0.0603171303294256 0.229241958280284 1.01910946835559 0.441176470588235 26.2 26 2 increased width of hypertrophic chondrocyte zone 0.0603171303294256 0.229241958280284 1.01910946835559 0.441176470588235 26.2 26 2 hypoglycemia 0.00319718182653937 0.027236266416153 1.01837892393383 0.440860215053763 26.2 26 2 increased hemoglobin content 0.0168115466329812 0.0911083273410472 1.01795793223316 0.440677966101695 26.2 26 2 weight loss 7.75342799171257e-05 0.00133471641033806 1.01639184310664 0.44 26.2 26 2 abnormal primitive streak morphology 0.101932934407346 0.293300375174406 1.01639184310664 0.44 26.2 26 2 increased pre-B cell number 0.101932934407346 0.293300375174406 1.01639184310664 0.44 26.2 26 2 thick ventricular wall 0.0440525074738889 0.180379608792261 1.0141382026563 0.439024390243902 26.2 26 2 abnormal facial morphology 0.0200957036288134 0.104796777309588 1.01314976386229 0.43859649122807 26.2 26 2 abnormal bone mineralization 0.00106202347997227 0.0113653665416636 1.01181006169519 0.43801652892562 26.2 26 2 decreased eosinophil cell number 0.0149928984359023 0.083061993005138 1.01061688945263 0.4375 26.2 26 2 abnormal depression-related behavior 0.0730415145297846 0.259743770397197 1.01061688945263 0.4375 26.2 26 2 increased fatty acid level 0.0730415145297846 0.259743770397197 1.01061688945263 0.4375 26.2 26 2 abnormal bone marrow cell number 0.180285156485793 0.450939493975274 1.01061688945263 0.4375 26.2 26 2 decreased mast cell number 0.180285156485793 0.450939493975274 1.01061688945263 0.4375 26.2 26 2 delayed hair appearance 0.180285156485793 0.450939493975274 1.01061688945263 0.4375 26.2 26 2 abnormal pituitary gland morphology 0.180285156485793 0.450939493975274 1.01061688945263 0.4375 26.2 26 2 mixed cellular infiltration to dermis 0.180285156485793 0.450939493975274 1.01061688945263 0.4375 26.2 26 2 reduced male mating frequency 0.180285156485793 0.450939493975274 1.01061688945263 0.4375 26.2 26 2 intraventricular hemorrhage 0.180285156485793 0.450939493975274 1.01061688945263 0.4375 26.2 26 2 impaired muscle relaxation 0.180285156485793 0.450939493975274 1.01061688945263 0.4375 26.2 26 2 large intestinal inflammation 0.180285156485793 0.450939493975274 1.01061688945263 0.4375 26.2 26 2 abnormal molar crown morphology 0.180285156485793 0.450939493975274 1.01061688945263 0.4375 26.2 26 2 bowed radius 0.180285156485793 0.450939493975274 1.01061688945263 0.4375 26.2 26 2 abnormal amnion morphology 0.180285156485793 0.450939493975274 1.01061688945263 0.4375 26.2 26 2 decreased circulating prolactin level 0.180285156485793 0.450939493975274 1.01061688945263 0.4375 26.2 26 2 abnormal osteoclast morphology 0.0324305227244678 0.140175369725653 1.01061688945263 0.4375 26.2 26 2 increased circulating calcium level 0.0240198343651 0.120462374966101 1.00799191051899 0.436363636363636 26.2 26 2 increased circulating alanine transaminase level 0.00842711928007553 0.0542366344351562 1.00691499608467 0.435897435897436 26.2 26 2 abnormal heart ventricle morphology 0.00842711928007553 0.0542366344351562 1.00691499608467 0.435897435897436 26.2 26 2 increased vascular permeability 0.0530442538692589 0.20779146692879 1.00691499608467 0.435897435897436 26.2 26 2 decreased B-1 B cell number 0.0530442538692589 0.20779146692879 1.00691499608467 0.435897435897436 26.2 26 2 abnormal circulating hormone level 0.0530442538692589 0.20779146692879 1.00691499608467 0.435897435897436 26.2 26 2 abnormal carpal bone morphology 0.124650583461436 0.349372762096138 1.00433976591566 0.434782608695652 26.2 26 2 hypotension 0.124650583461436 0.349372762096138 1.00433976591566 0.434782608695652 26.2 26 2 failure of embryo implantation 0.124650583461436 0.349372762096138 1.00433976591566 0.434782608695652 26.2 26 2 increased susceptibility to age related obesity 0.124650583461436 0.349372762096138 1.00433976591566 0.434782608695652 26.2 26 2 abnormal palatal shelf fusion at midline 0.124650583461436 0.349372762096138 1.00433976591566 0.434782608695652 26.2 26 2 decreased effector memory CD8-positive, alpha-beta T cell number 0.124650583461436 0.349372762096138 1.00433976591566 0.434782608695652 26.2 26 2 abnormal pancreatic islet morphology 0.0287076249038256 0.131268781154901 1.00244478522525 0.433962264150943 26.2 26 2 abnormal femur morphology 0.0158860405390795 0.0867506358282566 0.999842722187676 0.432835820895522 26.2 26 2 internal hemorrhage 0.0158860405390795 0.0867506358282566 0.999842722187676 0.432835820895522 26.2 26 2 abnormal angiogenesis 0.0118854125844082 0.0682793621332917 0.998910902316113 0.432432432432432 26.2 26 2 decreased width of hypertrophic chondrocyte zone 0.0638897748856546 0.239346106969979 0.998910902316113 0.432432432432432 26.2 26 2 abnormal calcium ion homeostasis 0.0638897748856546 0.239346106969979 0.998910902316113 0.432432432432432 26.2 26 2 short femur 0.00670926859226408 0.0472784861848638 0.997491994784414 0.431818181818182 26.2 26 2 muscular atrophy 0.0466282963119417 0.18952269130058 0.997491994784414 0.431818181818182 26.2 26 2 abnormal lipid homeostasis 0.00126128024561151 0.012991447664425 0.995068937307204 0.430769230769231 26.2 26 2 cochlear outer hair cell degeneration 0.0141086810074905 0.0790435675813796 0.99457535152481 0.430555555555556 26.2 26 2 increased T cell proliferation 0.00341099127773099 0.0285143383596939 0.993076142372677 0.429906542056075 26.2 26 2 increased circulating aspartate transaminase level 0.0224593224293021 0.113373652324945 0.989992054974005 0.428571428571429 26.2 26 2 abnormal locomotor activation 0.00706873051504678 0.0488429643227191 0.989992054974004 0.428571428571429 26.2 26 2 polyuria 0.0125246653439788 0.0712931465518246 0.989992054974004 0.428571428571429 26.2 26 2 abnormal seminal vesicle morphology 0.0302596794177577 0.135623337930941 0.989992054974004 0.428571428571429 26.2 26 2 abnormal artery morphology 0.0769738285181246 0.271599818046161 0.989992054974004 0.428571428571429 26.2 26 2 decreased circulating thyroxine level 0.0769738285181246 0.271599818046161 0.989992054974004 0.428571428571429 26.2 26 2 abnormal kidney blood vessel morphology 0.224815382274179 0.510477648021014 0.989992054974004 0.428571428571429 26.2 26 2 abnormal pinna reflex 0.224815382274179 0.510477648021014 0.989992054974004 0.428571428571429 26.2 26 2 extended life span 0.224815382274179 0.510477648021014 0.989992054974004 0.428571428571429 26.2 26 2 abnormal fluid regulation 0.224815382274179 0.510477648021014 0.989992054974004 0.428571428571429 26.2 26 2 abnormal spleen periarteriolar lymphoid sheath morphology 0.224815382274179 0.510477648021014 0.989992054974004 0.428571428571429 26.2 26 2 abnormal endplate potential 0.224815382274179 0.510477648021014 0.989992054974004 0.428571428571429 26.2 26 2 abnormal vascular endothelial cell migration 0.224815382274179 0.510477648021014 0.989992054974004 0.428571428571429 26.2 26 2 abnormal pancreas development 0.224815382274179 0.510477648021014 0.989992054974004 0.428571428571429 26.2 26 2 increased circulating growth hormone level 0.224815382274179 0.510477648021014 0.989992054974004 0.428571428571429 26.2 26 2 increased pulmonary respiratory rate 0.224815382274179 0.510477648021014 0.989992054974004 0.428571428571429 26.2 26 2 pulmonary alveolar hemorrhage 0.224815382274179 0.510477648021014 0.989992054974004 0.428571428571429 26.2 26 2 decreased compact bone area 0.224815382274179 0.510477648021014 0.989992054974004 0.428571428571429 26.2 26 2 small ears 0.152715429035344 0.407234790203871 0.989992054974004 0.428571428571429 26.2 26 2 abnormal clavicle morphology 0.152715429035344 0.407234790203871 0.989992054974004 0.428571428571429 26.2 26 2 increased B cell number 0.00271568285697247 0.0237443272643903 0.987171564788893 0.427350427350427 26.2 26 2 sparse hair 0.0111152655697092 0.0668997915537963 0.985967697026956 0.426829268292683 26.2 26 2 abnormal chondrocyte morphology 0.036044075580595 0.151580114973339 0.983880992906264 0.425925925925926 26.2 26 2 abnormal T cell differentiation 0.00559439896965151 0.0412133076333834 0.983457453951074 0.425742574257426 26.2 26 2 decreased bone trabecula number 0.0489663325306326 0.196299358855679 0.982970834725962 0.425531914893617 26.2 26 2 abnormal female reproductive system morphology 0.0670409291814642 0.248161177587637 0.981742121182554 0.425 26.2 26 2 increased bone mineral density 0.00376153131615637 0.030778977463615 0.981231063337066 0.424778761061947 26.2 26 2 abnormal aorta morphology 0.092760332813118 0.276006373053386 0.979992135226792 0.424242424242424 26.2 26 2 increased cardiomyocyte apoptosis 0.092760332813118 0.276006373053386 0.979992135226792 0.424242424242424 26.2 26 2 decreased sensitivity to xenobiotic induced morbidity/mortality 0.092760332813118 0.276006373053386 0.979992135226792 0.424242424242424 26.2 26 2 cardiac fibrosis 0.0116419135050332 0.0673670256870145 0.978345089621369 0.423529411764706 26.2 26 2 increased susceptibility to otitis media 0.130308834410192 0.356397169428645 0.977299849141004 0.423076923076923 26.2 26 2 increased leukemia incidence 0.130308834410192 0.356397169428645 0.977299849141004 0.423076923076923 26.2 26 2 abnormal erythrocyte osmotic lysis 0.130308834410192 0.356397169428645 0.977299849141004 0.423076923076923 26.2 26 2 decreased Peyer's patch number 0.130308834410192 0.356397169428645 0.977299849141004 0.423076923076923 26.2 26 2 increased circulating corticosterone level 0.0584798444476376 0.226893091598174 0.975325506011427 0.422222222222222 26.2 26 2 alopecia 0.00913813663760246 0.0585099482266052 0.972623773307794 0.421052631578947 26.2 26 2 hyporesponsive to tactile stimuli 0.0803775894275299 0.272054586125999 0.972623773307794 0.421052631578947 26.2 26 2 shiny skin 0.187486945904511 0.467777109265266 0.972623773307794 0.421052631578947 26.2 26 2 abnormal cochlear inner hair cell morphology 0.187486945904511 0.467777109265266 0.972623773307794 0.421052631578947 26.2 26 2 abnormal blastocyst morphology 0.187486945904511 0.467777109265266 0.972623773307794 0.421052631578947 26.2 26 2 increased circulating VLDL cholesterol level 0.187486945904511 0.467777109265266 0.972623773307794 0.421052631578947 26.2 26 2 decreased liver glycogen level 0.187486945904511 0.467777109265266 0.972623773307794 0.421052631578947 26.2 26 2 kidney inflammation 0.0510859377897378 0.203322032403156 0.970192213874524 0.42 26.2 26 2 abnormal organ of Corti morphology 0.0698193816092374 0.257106901188716 0.966968983928097 0.418604651162791 26.2 26 2 increased circulating glucose level 0.00218443621440902 0.0199771510417001 0.966587987480529 0.418439716312057 26.2 26 2 cardiac hypertrophy 0.00951442672269033 0.0604524558689456 0.966420815569862 0.418367346938776 26.2 26 2 decreased circulating calcium level 0.0446864989542318 0.182825108797124 0.965992247580695 0.418181818181818 26.2 26 2 abnormal response to infection 0.019086815426936 0.100059964962072 0.964928964974663 0.417721518987342 26.2 26 2 abnormal tumor morphology 0.158300624662046 0.418017838478599 0.962492275669171 0.416666666666667 26.2 26 2 abnormal osteoblast morphology 0.158300624662046 0.418017838478599 0.962492275669171 0.416666666666667 26.2 26 2 increased body temperature 0.158300624662046 0.418017838478599 0.962492275669171 0.416666666666667 26.2 26 2 abnormal mineral level 0.281928442812536 0.542218458185031 0.962492275669171 0.416666666666667 26.2 26 2 impaired embryo implantation 0.281928442812536 0.542218458185031 0.962492275669171 0.416666666666667 26.2 26 2 increased growth rate 0.281928442812536 0.542218458185031 0.962492275669171 0.416666666666667 26.2 26 2 abnormal aorta elastic fiber morphology 0.281928442812536 0.542218458185031 0.962492275669171 0.416666666666667 26.2 26 2 abnormal alisphenoid bone morphology 0.281928442812536 0.542218458185031 0.962492275669171 0.416666666666667 26.2 26 2 absent tail 0.281928442812536 0.542218458185031 0.962492275669171 0.416666666666667 26.2 26 2 increased fear-related response 0.281928442812536 0.542218458185031 0.962492275669171 0.416666666666667 26.2 26 2 abnormal rostral-caudal body axis extension 0.281928442812536 0.542218458185031 0.962492275669171 0.416666666666667 26.2 26 2 increased hepatocyte proliferation 0.281928442812536 0.542218458185031 0.962492275669171 0.416666666666667 26.2 26 2 absent cochlear hair cells 0.281928442812536 0.542218458185031 0.962492275669171 0.416666666666667 26.2 26 2 small parietal bone 0.281928442812536 0.542218458185031 0.962492275669171 0.416666666666667 26.2 26 2 hematuria 0.281928442812536 0.542218458185031 0.962492275669171 0.416666666666667 26.2 26 2 abnormal anogenital distance 0.281928442812536 0.542218458185031 0.962492275669171 0.416666666666667 26.2 26 2 abnormal amacrine cell morphology 0.281928442812536 0.542218458185031 0.962492275669171 0.416666666666667 26.2 26 2 decreased renal glomerular filtration rate 0.281928442812536 0.542218458185031 0.962492275669171 0.416666666666667 26.2 26 2 decreased keratinocyte proliferation 0.281928442812536 0.542218458185031 0.962492275669171 0.416666666666667 26.2 26 2 hydrometra 0.281928442812536 0.542218458185031 0.962492275669171 0.416666666666667 26.2 26 2 increased type II pneumocyte number 0.281928442812536 0.542218458185031 0.962492275669171 0.416666666666667 26.2 26 2 abnormal uterus morphology 0.0963515123119647 0.282634890183977 0.962492275669171 0.416666666666667 26.2 26 2 abnormal trophoblast giant cell morphology 0.0963515123119647 0.282634890183977 0.962492275669171 0.416666666666667 26.2 26 2 decreased monocyte cell number 0.034313910610964 0.144548438009776 0.959530760974804 0.415384615384615 26.2 26 2 increased tumor growth/size 0.0833243945576635 0.272054586125999 0.957797191397614 0.414634146341463 26.2 26 2 abnormal cholesterol homeostasis 0.0833243945576635 0.272054586125999 0.957797191397614 0.414634146341463 26.2 26 2 abnormal enzyme/coenzyme level 0.0463026226787134 0.188970917002953 0.955854397905935 0.413793103448276 26.2 26 2 abnormal microglial cell morphology 0.134785239916746 0.367175057455613 0.955854397905935 0.413793103448276 26.2 26 2 decreased granulocyte number 0.134785239916746 0.367175057455613 0.955854397905935 0.413793103448276 26.2 26 2 decreased retinal photoreceptor cell number 0.134785239916746 0.367175057455613 0.955854397905935 0.413793103448276 26.2 26 2 increased double-positive T cell number 0.134785239916746 0.367175057455613 0.955854397905935 0.413793103448276 26.2 26 2 abnormal immune system morphology 0.0722679955078357 0.257360971833559 0.954122777619874 0.41304347826087 26.2 26 2 impaired hematopoiesis 0.0628317894060029 0.236272223956814 0.951168837131887 0.411764705882353 26.2 26 2 abnormal trophoblast layer morphology 0.0628317894060029 0.236272223956814 0.951168837131887 0.411764705882353 26.2 26 2 decreased osteoblast cell number 0.115470574551703 0.329584686399725 0.951168837131887 0.411764705882353 26.2 26 2 abnormal skin physiology 0.115470574551703 0.329584686399725 0.951168837131887 0.411764705882353 26.2 26 2 abnormal melanosome morphology 0.230704847289813 0.52265783937469 0.951168837131887 0.411764705882353 26.2 26 2 abnormal electroretinogram waveform feature 0.230704847289813 0.52265783937469 0.951168837131887 0.411764705882353 26.2 26 2 delayed heart development 0.230704847289813 0.52265783937469 0.951168837131887 0.411764705882353 26.2 26 2 decreased body fat mass 0.230704847289813 0.52265783937469 0.951168837131887 0.411764705882353 26.2 26 2 abnormal eye development 0.0547415549948049 0.214271625569752 0.948742386016754 0.410714285714286 26.2 26 2 acanthosis 0.099392083728936 0.290526214190045 0.947684702197338 0.41025641025641 26.2 26 2 abnormal lens fiber morphology 0.099392083728936 0.290526214190045 0.947684702197338 0.41025641025641 26.2 26 2 increased autoantibody level 0.099392083728936 0.290526214190045 0.947684702197338 0.41025641025641 26.2 26 2 decreased trabecular bone volume 0.099392083728936 0.290526214190045 0.947684702197338 0.41025641025641 26.2 26 2 increased double-negative T cell number 0.0477789127364482 0.194040890501086 0.946713713772955 0.409836065573771 26.2 26 2 increased circulating HDL cholesterol level 0.0123510389398657 0.0705469790193247 0.945992408086271 0.40952380952381 26.2 26 2 abnormal myelopoiesis 0.0858747483535191 0.272054586125999 0.94499241611155 0.409090909090909 26.2 26 2 abnormal astrocyte morphology 0.0858747483535191 0.272054586125999 0.94499241611155 0.409090909090909 26.2 26 2 abnormal photoreceptor outer segment morphology 0.0858747483535191 0.272054586125999 0.94499241611155 0.409090909090909 26.2 26 2 abnormal amino acid level 0.0858747483535191 0.272054586125999 0.94499241611155 0.409090909090909 26.2 26 2 decreased blood urea nitrogen level 0.0858747483535191 0.272054586125999 0.94499241611155 0.409090909090909 26.2 26 2 increased bone volume 0.192461302951868 0.479466691129465 0.94499241611155 0.409090909090909 26.2 26 2 impaired humoral immune response 0.192461302951868 0.479466691129465 0.94499241611155 0.409090909090909 26.2 26 2 abnormal respiratory system physiology 0.0744242295670002 0.264283042181175 0.942849576165719 0.408163265306122 26.2 26 2 increased fluid intake 0.0744242295670002 0.264283042181175 0.942849576165719 0.408163265306122 26.2 26 2 polyphagia 0.0646662404055763 0.239549177973002 0.941103558432078 0.407407407407407 26.2 26 2 abnormal osteoblast physiology 0.0646662404055763 0.239549177973002 0.941103558432078 0.407407407407407 26.2 26 2 decreased platelet aggregation 0.0646662404055763 0.239549177973002 0.941103558432078 0.407407407407407 26.2 26 2 thin epidermis 0.162493105321732 0.421036857944892 0.941103558432078 0.407407407407407 26.2 26 2 abnormal type II pneumocyte morphology 0.162493105321732 0.421036857944892 0.941103558432078 0.407407407407407 26.2 26 2 cryptorchism 0.162493105321732 0.421036857944892 0.941103558432078 0.407407407407407 26.2 26 2 abnormal single cell response 0.162493105321732 0.421036857944892 0.941103558432078 0.407407407407407 26.2 26 2 abnormal fetal cardiomyocyte proliferation 0.162493105321732 0.421036857944892 0.941103558432078 0.407407407407407 26.2 26 2 small ovary 0.0217105168831412 0.112510230722529 0.939223231642004 0.406593406593407 26.2 26 2 increased thermal nociceptive threshold 0.0217105168831412 0.112510230722529 0.939223231642004 0.406593406593407 26.2 26 2 abnormal cardiovascular system physiology 0.00683148707377558 0.0480161379521708 0.937887209975373 0.406015037593985 26.2 26 2 abnormal eye electrophysiology 0.0101701483071008 0.0631666514704448 0.935447038171029 0.40495867768595 26.2 26 2 abnormal skin condition 0.0763207550535839 0.270631330286229 0.932877128725504 0.403846153846154 26.2 26 2 abnormal hair growth 0.0763207550535839 0.270631330286229 0.932877128725504 0.403846153846154 26.2 26 2 increased circulating cholesterol level 0.00264307647094288 0.0232731069786563 0.931867521443334 0.403409090909091 26.2 26 2 decreased neutrophil cell number 0.0137178451672344 0.0771144403468826 0.92794127090156 0.401709401709402 26.2 26 2 epidermal hyperplasia 0.0677592581886699 0.250447481046533 0.923992584642404 0.4 26.2 26 2 abnormal eye physiology 0.0677592581886699 0.250447481046533 0.923992584642404 0.4 26.2 26 2 increased body length 0.089983090751842 0.272054586125999 0.923992584642404 0.4 26.2 26 2 altered response to myocardial infarction 0.104138017624106 0.299299039676447 0.923992584642404 0.4 26.2 26 2 abnormal ectoderm development 0.104138017624106 0.299299039676447 0.923992584642404 0.4 26.2 26 2 increased susceptibility to weight loss 0.120959520093917 0.341217369940909 0.923992584642404 0.4 26.2 26 2 abnormal fat pad morphology 0.165630862567508 0.421036857944892 0.923992584642404 0.4 26.2 26 2 abnormal thyroid gland morphology 0.195879084831846 0.482285468580986 0.923992584642404 0.4 26.2 26 2 increased liver glycogen level 0.195879084831846 0.482285468580986 0.923992584642404 0.4 26.2 26 2 abnormal Peyer's patch T cell area morphology 0.234169326878722 0.528820881171875 0.923992584642404 0.4 26.2 26 2 abnormal male reproductive system physiology 0.234169326878722 0.528820881171875 0.923992584642404 0.4 26.2 26 2 abnormal optic stalk morphology 0.234169326878722 0.528820881171875 0.923992584642404 0.4 26.2 26 2 dilated vasculature 0.234169326878722 0.528820881171875 0.923992584642404 0.4 26.2 26 2 kidney atrophy 0.234169326878722 0.528820881171875 0.923992584642404 0.4 26.2 26 2 decreased circulating VLDL cholesterol level 0.234169326878722 0.528820881171875 0.923992584642404 0.4 26.2 26 2 macrocytosis 0.284602182490302 0.542218458185031 0.923992584642404 0.4 26.2 26 2 vagina atresia 0.284602182490302 0.542218458185031 0.923992584642404 0.4 26.2 26 2 abnormal epidermis stratum spinosum morphology 0.284602182490302 0.542218458185031 0.923992584642404 0.4 26.2 26 2 abnormal apical ectodermal ridge morphology 0.284602182490302 0.542218458185031 0.923992584642404 0.4 26.2 26 2 placental labyrinth hypoplasia 0.284602182490302 0.542218458185031 0.923992584642404 0.4 26.2 26 2 decreased aggression towards males 0.284602182490302 0.542218458185031 0.923992584642404 0.4 26.2 26 2 abnormal Muller cell morphology 0.284602182490302 0.542218458185031 0.923992584642404 0.4 26.2 26 2 absent chorion 0.284602182490302 0.542218458185031 0.923992584642404 0.4 26.2 26 2 liver vascular congestion 0.284602182490302 0.542218458185031 0.923992584642404 0.4 26.2 26 2 decreased bone mineralization 0.141135071907421 0.383268003678723 0.923992584642404 0.4 26.2 26 2 abnormal definitive hematopoiesis 0.0308563553804723 0.136605504771673 0.919024882574434 0.397849462365591 26.2 26 2 abnormal hair follicle morphology 0.0690539559749464 0.254476615537303 0.916659310161115 0.396825396825397 26.2 26 2 decreased IgG level 0.0213486724197674 0.110866018046287 0.915668327123103 0.396396396396396 26.2 26 2 abnormal urine homeostasis 0.0314313957926616 0.136605504771673 0.914367661885712 0.395833333333333 26.2 26 2 abnormal cardiovascular system morphology 0.105967495030913 0.304205590178183 0.914367661885712 0.395833333333333 26.2 26 2 abnormal lymph node morphology 0.105967495030913 0.304205590178183 0.914367661885712 0.395833333333333 26.2 26 2 abnormal blood circulation 0.12298316978975 0.346064066574664 0.913248484820981 0.395348837209302 26.2 26 2 increased bone marrow cell number 0.143336857934218 0.389034843547591 0.911834787476057 0.394736842105263 26.2 26 2 abnormal epidermis stratum basale morphology 0.167953064618742 0.425657919754582 0.909992696996307 0.393939393939394 26.2 26 2 abnormal T cell subpopulation ratio 0.167953064618742 0.425657919754582 0.909992696996307 0.393939393939394 26.2 26 2 increased osteoblast cell number 0.167953064618742 0.425657919754582 0.909992696996307 0.393939393939394 26.2 26 2 increased leukocyte cell number 0.0119691143353189 0.068680904057914 0.908061678010639 0.393103448275862 26.2 26 2 enhanced coordination 0.19817054158348 0.48257388368958 0.907492717059504 0.392857142857143 26.2 26 2 delayed wound healing 0.124625888984566 0.349372762096138 0.903905789324091 0.391304347826087 26.2 26 2 abnormal B cell morphology 0.236053908338573 0.532834933749729 0.903905789324091 0.391304347826087 26.2 26 2 increased B cell proliferation 0.0942256934866961 0.280198939089249 0.900501247744716 0.389830508474576 26.2 26 2 head tilt 0.169633700740894 0.427589891160387 0.898326123957893 0.388888888888889 26.2 26 2 thick dermal layer 0.285089149026679 0.542218458185031 0.898326123957893 0.388888888888889 26.2 26 2 abnormal iron level 0.285089149026679 0.542218458185031 0.898326123957893 0.388888888888889 26.2 26 2 abnormal redox activity 0.285089149026679 0.542218458185031 0.898326123957893 0.388888888888889 26.2 26 2 abnormal sperm axoneme morphology 0.285089149026679 0.542218458185031 0.898326123957893 0.388888888888889 26.2 26 2 primary atelectasis 0.285089149026679 0.542218458185031 0.898326123957893 0.388888888888889 26.2 26 2 decreased fluid intake 0.285089149026679 0.542218458185031 0.898326123957893 0.388888888888889 26.2 26 2 impaired leukocyte tethering or rolling 0.285089149026679 0.542218458185031 0.898326123957893 0.388888888888889 26.2 26 2 maternal effect 0.0827887469913818 0.272054586125999 0.896410716444123 0.388059701492537 26.2 26 2 small cranium 0.199624531453901 0.485639141312057 0.894186372234585 0.387096774193548 26.2 26 2 increased liver weight 0.056261576782361 0.219728171748488 0.892492837438686 0.386363636363636 26.2 26 2 hypertension 0.146347731434784 0.394409514565576 0.892492837438686 0.386363636363636 26.2 26 2 abnormal gametogenesis 0.146347731434784 0.394409514565576 0.892492837438686 0.386363636363636 26.2 26 2 decreased sensitivity to induced morbidity/mortality 0.146347731434784 0.394409514565576 0.892492837438686 0.386363636363636 26.2 26 2 absent corpus luteum 0.126987124554859 0.353364222351615 0.888454408310004 0.384615384615385 26.2 26 2 abnormal kidney cortex morphology 0.23686049134538 0.534170872367755 0.888454408310004 0.384615384615385 26.2 26 2 abnormal ocular fundus morphology 0.23686049134538 0.534170872367755 0.888454408310004 0.384615384615385 26.2 26 2 short premaxilla 0.352042006625427 0.592644877800582 0.888454408310004 0.384615384615385 26.2 26 2 absent myocardial trabeculae 0.352042006625427 0.592644877800582 0.888454408310004 0.384615384615385 26.2 26 2 small trigeminal ganglion 0.352042006625427 0.592644877800582 0.888454408310004 0.384615384615385 26.2 26 2 abnormal intercostal muscle morphology 0.352042006625427 0.592644877800582 0.888454408310004 0.384615384615385 26.2 26 2 abnormal vestibulocochlear ganglion morphology 0.352042006625427 0.592644877800582 0.888454408310004 0.384615384615385 26.2 26 2 vestibular hair cell degeneration 0.352042006625427 0.592644877800582 0.888454408310004 0.384615384615385 26.2 26 2 increased circulating ammonia level 0.352042006625427 0.592644877800582 0.888454408310004 0.384615384615385 26.2 26 2 small pituitary gland 0.352042006625427 0.592644877800582 0.888454408310004 0.384615384615385 26.2 26 2 increased renin activity 0.352042006625427 0.592644877800582 0.888454408310004 0.384615384615385 26.2 26 2 increased prostaglandin level 0.352042006625427 0.592644877800582 0.888454408310004 0.384615384615385 26.2 26 2 abnormal bone remodeling 0.200442225136434 0.487390063564887 0.883228205908181 0.382352941176471 26.2 26 2 increased sensitivity to xenobiotic induced morbidity/mortality 0.0448613437061025 0.183389634295694 0.881992921704113 0.381818181818182 26.2 26 2 abnormal T-helper 2 physiology 0.127791403655604 0.353364222351615 0.881992921704113 0.381818181818182 26.2 26 2 skin lesions 0.111357834510594 0.318393808442646 0.879992937754671 0.380952380952381 26.2 26 2 abnormal associative learning 0.284294802474648 0.542218458185031 0.879992937754671 0.380952380952381 26.2 26 2 increased vasoconstriction 0.284294802474648 0.542218458185031 0.879992937754671 0.380952380952381 26.2 26 2 liver degeneration 0.284294802474648 0.542218458185031 0.879992937754671 0.380952380952381 26.2 26 2 dry skin 0.284294802474648 0.542218458185031 0.879992937754671 0.380952380952381 26.2 26 2 decreased cochlear outer hair cell number 0.284294802474648 0.542218458185031 0.879992937754671 0.380952380952381 26.2 26 2 abnormal tumor vascularization 0.284294802474648 0.542218458185031 0.879992937754671 0.380952380952381 26.2 26 2 abnormal circulating protein level 0.147986003234985 0.398393055245699 0.877792955410284 0.38 26.2 26 2 decreased oocyte number 0.147986003234985 0.398393055245699 0.877792955410284 0.38 26.2 26 2 impaired skeletal muscle contractility 0.200767987651141 0.487467417552184 0.874047039526598 0.378378378378378 26.2 26 2 decreased circulating chloride level 0.200767987651141 0.487467417552184 0.874047039526598 0.378378378378378 26.2 26 2 abnormal trabecular bone morphology 0.0456978832928608 0.18665596829391 0.873522401447651 0.378151260504202 26.2 26 2 abnormal response/metabolism to endogenous compounds 0.0858228041904891 0.272054586125999 0.873285674509589 0.378048780487805 26.2 26 2 abnormal cartilage development 0.171975057676981 0.432983761104748 0.872659663273382 0.377777777777778 26.2 26 2 abnormal blood homeostasis 0.0518702387592877 0.204041092408508 0.871308796921565 0.37719298245614 26.2 26 2 abnormal epidermal layer morphology 0.112277836246866 0.320839882440068 0.870427797126902 0.376811594202899 26.2 26 2 abnormal pancreatic beta cell morphology 0.20070803484368 0.487467417552184 0.866243048102254 0.375 26.2 26 2 absent mandible 0.347192398093008 0.592644877800582 0.866243048102254 0.375 26.2 26 2 abnormal mouth morphology 0.347192398093008 0.592644877800582 0.866243048102254 0.375 26.2 26 2 abnormal meiosis 0.347192398093008 0.592644877800582 0.866243048102254 0.375 26.2 26 2 abnormal pulmonary elastic fiber morphology 0.347192398093008 0.592644877800582 0.866243048102254 0.375 26.2 26 2 decreased aggression towards mice 0.347192398093008 0.592644877800582 0.866243048102254 0.375 26.2 26 2 small pancreas 0.347192398093008 0.592644877800582 0.866243048102254 0.375 26.2 26 2 small epididymis 0.347192398093008 0.592644877800582 0.866243048102254 0.375 26.2 26 2 abnormal Langerhans cell physiology 0.347192398093008 0.592644877800582 0.866243048102254 0.375 26.2 26 2 abnormal thoracic cage shape 0.347192398093008 0.592644877800582 0.866243048102254 0.375 26.2 26 2 abnormal urinary bladder physiology 0.347192398093008 0.592644877800582 0.866243048102254 0.375 26.2 26 2 abnormal foregut morphology 0.28270587854449 0.542218458185031 0.866243048102254 0.375 26.2 26 2 abnormal body weight 0.28270587854449 0.542218458185031 0.866243048102254 0.375 26.2 26 2 decreased metastatic potential 0.28270587854449 0.542218458185031 0.866243048102254 0.375 26.2 26 2 small lymph nodes 0.28270587854449 0.542218458185031 0.866243048102254 0.375 26.2 26 2 abnormal primitive streak formation 0.28270587854449 0.542218458185031 0.866243048102254 0.375 26.2 26 2 hypopigmentation 0.28270587854449 0.542218458185031 0.866243048102254 0.375 26.2 26 2 decreased compact bone thickness 0.129204679768959 0.354183992622267 0.861933381196272 0.373134328358209 26.2 26 2 decreased T cell proliferation 0.0413972776579343 0.170630866899936 0.858439056677909 0.371621621621622 26.2 26 2 thick epidermis 0.129214863640083 0.354183992622267 0.857993114310804 0.371428571428571 26.2 26 2 increased eosinophil cell number 0.148607216499308 0.399849054669583 0.85692860672481 0.370967741935484 26.2 26 2 abnormal palate morphology 0.280606012535762 0.542218458185031 0.855548689483708 0.37037037037037 26.2 26 2 abnormal bone trabecula morphology 0.280606012535762 0.542218458185031 0.855548689483708 0.37037037037037 26.2 26 2 thin dermal layer 0.34202376751461 0.592644877800582 0.85104580164432 0.368421052631579 26.2 26 2 short vibrissae 0.34202376751461 0.592644877800582 0.85104580164432 0.368421052631579 26.2 26 2 abnormal neurotransmitter level 0.34202376751461 0.592644877800582 0.85104580164432 0.368421052631579 26.2 26 2 abnormal neural crest cell migration 0.34202376751461 0.592644877800582 0.85104580164432 0.368421052631579 26.2 26 2 oliguria 0.34202376751461 0.592644877800582 0.85104580164432 0.368421052631579 26.2 26 2 abnormal photoreceptor inner segment morphology 0.34202376751461 0.592644877800582 0.85104580164432 0.368421052631579 26.2 26 2 decreased susceptibility to weight gain 0.34202376751461 0.592644877800582 0.85104580164432 0.368421052631579 26.2 26 2 embryonic lethality between implantation and somite formation, incomplete penetrance 0.34202376751461 0.592644877800582 0.85104580164432 0.368421052631579 26.2 26 2 abnormal epidermis stratum corneum morphology 0.198923343460334 0.484170075203113 0.848564618549147 0.36734693877551 26.2 26 2 abnormal lactation 0.278170559113258 0.542218458185031 0.84699320258887 0.366666666666667 26.2 26 2 abnormal estrous cycle 0.278170559113258 0.542218458185031 0.84699320258887 0.366666666666667 26.2 26 2 abnormal pain threshold 0.278170559113258 0.542218458185031 0.84699320258887 0.366666666666667 26.2 26 2 arrested B cell differentiation 0.232820747001311 0.52721129555372 0.845115168880248 0.365853658536585 26.2 26 2 decreased cardiac muscle contractility 0.0981606525695809 0.287602618688849 0.844031687894504 0.365384615384615 26.2 26 2 increased percent body fat/body weight 0.197955161174347 0.482285468580986 0.844031687894504 0.365384615384615 26.2 26 2 abnormal dendritic cell physiology 0.0979011348228997 0.287011282111919 0.841955859837705 0.364485981308411 26.2 26 2 increased sensitivity to induced morbidity/mortality 0.0411707929938705 0.169979000119922 0.841134553954363 0.364130434782609 26.2 26 2 diarrhea 0.27551291018923 0.542218458185031 0.839993258765822 0.363636363636364 26.2 26 2 increased body size 0.336771087916236 0.592644877800582 0.839993258765822 0.363636363636364 26.2 26 2 abnormal chorion morphology 0.336771087916236 0.592644877800582 0.839993258765822 0.363636363636364 26.2 26 2 abnormal retinal layer morphology 0.336771087916236 0.592644877800582 0.839993258765822 0.363636363636364 26.2 26 2 abnormal circulating lipid level 0.336771087916236 0.592644877800582 0.839993258765822 0.363636363636364 26.2 26 2 decreased IgM level 0.125803670204751 0.35240611445306 0.833498465527942 0.360824742268041 26.2 26 2 increased circulating chloride level 0.227575597337093 0.516509396328484 0.831593326178164 0.36 26.2 26 2 liver inflammation 0.107891517864422 0.309550346814012 0.827743357075487 0.358333333333333 26.2 26 2 increased circulating luteinizing hormone level 0.32640349639814 0.584541898697174 0.824993379145004 0.357142857142857 26.2 26 2 abnormal spleen germinal center morphology 0.32640349639814 0.584541898697174 0.824993379145004 0.357142857142857 26.2 26 2 translucent skin 0.422723464598342 0.690203228216853 0.824993379145004 0.357142857142857 26.2 26 2 abnormal placing response 0.422723464598342 0.690203228216853 0.824993379145004 0.357142857142857 26.2 26 2 abnormal kidney medulla morphology 0.422723464598342 0.690203228216853 0.824993379145004 0.357142857142857 26.2 26 2 abnormal uterus development 0.422723464598342 0.690203228216853 0.824993379145004 0.357142857142857 26.2 26 2 vascular smooth muscle hypoplasia 0.422723464598342 0.690203228216853 0.824993379145004 0.357142857142857 26.2 26 2 abnormal sagittal suture morphology 0.422723464598342 0.690203228216853 0.824993379145004 0.357142857142857 26.2 26 2 abnormal squamosal bone morphology 0.422723464598342 0.690203228216853 0.824993379145004 0.357142857142857 26.2 26 2 abnormal positive T cell selection 0.422723464598342 0.690203228216853 0.824993379145004 0.357142857142857 26.2 26 2 abnormal iris pigmentation 0.422723464598342 0.690203228216853 0.824993379145004 0.357142857142857 26.2 26 2 premature hair loss 0.422723464598342 0.690203228216853 0.824993379145004 0.357142857142857 26.2 26 2 decreased cornea thickness 0.422723464598342 0.690203228216853 0.824993379145004 0.357142857142857 26.2 26 2 abnormal immune system physiology 0.119281393463059 0.339487947642287 0.819670841215036 0.354838709677419 26.2 26 2 short maxilla 0.316460556581664 0.567143828888248 0.815287574684474 0.352941176470588 26.2 26 2 distended urinary bladder 0.410731062167478 0.673274146386557 0.815287574684474 0.352941176470588 26.2 26 2 increased aggression towards mice 0.410731062167478 0.673274146386557 0.815287574684474 0.352941176470588 26.2 26 2 abnormal heart rate 0.410731062167478 0.673274146386557 0.815287574684474 0.352941176470588 26.2 26 2 abnormal duodenum morphology 0.410731062167478 0.673274146386557 0.815287574684474 0.352941176470588 26.2 26 2 aminoaciduria 0.410731062167478 0.673274146386557 0.815287574684474 0.352941176470588 26.2 26 2 abnormal ectoplacental cone morphology 0.410731062167478 0.673274146386557 0.815287574684474 0.352941176470588 26.2 26 2 abnormal tendon morphology 0.410731062167478 0.673274146386557 0.815287574684474 0.352941176470588 26.2 26 2 increased hepatoma incidence 0.410731062167478 0.673274146386557 0.815287574684474 0.352941176470588 26.2 26 2 increased insulin secretion 0.311677041065736 0.558973784896192 0.811615108131841 0.351351351351351 26.2 26 2 abnormal circulating amino acid level 0.251929676775066 0.542218458185031 0.810519811089828 0.350877192982456 26.2 26 2 decreased circulating phosphate level 0.307020407950585 0.550820962695334 0.808493511562104 0.35 26.2 26 2 brain inflammation 0.400099235549319 0.657796991691296 0.808493511562104 0.35 26.2 26 2 abnormal dopamine level 0.400099235549319 0.657796991691296 0.808493511562104 0.35 26.2 26 2 abnormal trachea morphology 0.400099235549319 0.657796991691296 0.808493511562104 0.35 26.2 26 2 decreased skin tensile strength 0.400099235549319 0.657796991691296 0.808493511562104 0.35 26.2 26 2 absent placental labyrinth 0.400099235549319 0.657796991691296 0.808493511562104 0.35 26.2 26 2 abnormal physiological neovascularization 0.400099235549319 0.657796991691296 0.808493511562104 0.35 26.2 26 2 abnormal thymocyte activation 0.400099235549319 0.657796991691296 0.808493511562104 0.35 26.2 26 2 enhanced behavioral response to xenobiotic 0.400099235549319 0.657796991691296 0.808493511562104 0.35 26.2 26 2 abnormal sleep pattern 0.298076984438103 0.542218458185031 0.803471812732525 0.347826086956522 26.2 26 2 abnormal blood vessel physiology 0.390486917024323 0.644122152584883 0.803471812732525 0.347826086956522 26.2 26 2 abnormal retinal cone cell morphology 0.390486917024323 0.644122152584883 0.803471812732525 0.347826086956522 26.2 26 2 decreased urine osmolality 0.293782129628747 0.542218458185031 0.801422139740861 0.346938775510204 26.2 26 2 decreased IgA level 0.289599069576724 0.542218458185031 0.799608967479004 0.346153846153846 26.2 26 2 small seminal vesicle 0.381673545770336 0.630211048857425 0.799608967479004 0.346153846153846 26.2 26 2 lung inflammation 0.155607392798336 0.411561286109369 0.798302416878548 0.345588235294118 26.2 26 2 focal hair loss 0.373507439916557 0.61775249786731 0.796545331588279 0.344827586206897 26.2 26 2 abnormal CD8-positive, alpha-beta T cell physiology 0.373507439916557 0.61775249786731 0.796545331588279 0.344827586206897 26.2 26 2 polydipsia 0.365879302315685 0.605740275880378 0.794056127427066 0.34375 26.2 26 2 impaired behavioral response to xenobiotic 0.358707441162325 0.594064420699923 0.791993643979204 0.342857142857143 26.2 26 2 abnormal reproductive system physiology 0.351928972827192 0.592644877800582 0.790256815812582 0.342105263157895 26.2 26 2 liver fibrosis 0.345494306220579 0.592644877800582 0.788774157621564 0.341463414634146 26.2 26 2 decreased macrophage cell number 0.339363534216807 0.592644877800582 0.787493680092958 0.340909090909091 26.2 26 2 increased systemic arterial blood pressure 0.333503987394685 0.592644877800582 0.786376667780769 0.340425531914894 26.2 26 2 abnormal digestive system physiology 0.32788852505172 0.586778925227449 0.785393696946044 0.34 26.2 26 2 abnormal colon morphology 0.312294628995215 0.559879560090521 0.783044563256275 0.338983050847458 26.2 26 2 abnormal CD4-positive, alpha-beta T cell physiology 0.293852818499989 0.542218458185031 0.780838803923158 0.338028169014085 26.2 26 2 abnormal cytokine secretion 0.190075938426086 0.473998894070065 0.779993740282549 0.337662337662338 26.2 26 2 small placenta 0.377110377371835 0.623090045640943 0.769993820535337 0.333333333333333 26.2 26 2 decreased osteoclast cell number 0.377110377371835 0.623090045640943 0.769993820535337 0.333333333333333 26.2 26 2 arrested T cell differentiation 0.421175880318206 0.690167985699301 0.769993820535337 0.333333333333333 26.2 26 2 decreased salivation 0.491784105652362 0.733564927250519 0.769993820535337 0.333333333333333 26.2 26 2 abnormal bronchus morphology 0.491784105652362 0.733564927250519 0.769993820535337 0.333333333333333 26.2 26 2 abnormal pericyte morphology 0.491784105652362 0.733564927250519 0.769993820535337 0.333333333333333 26.2 26 2 greasy coat 0.491784105652362 0.733564927250519 0.769993820535337 0.333333333333333 26.2 26 2 decreased trabecular bone mass 0.491784105652362 0.733564927250519 0.769993820535337 0.333333333333333 26.2 26 2 abnormal branching involved in lung morphogenesis 0.491784105652362 0.733564927250519 0.769993820535337 0.333333333333333 26.2 26 2 increased lymphocyte cell number 0.327186042797349 0.585732480358695 0.769993820535337 0.333333333333333 26.2 26 2 abnormal kidney physiology 0.36982001183748 0.61206073150082 0.769993820535337 0.333333333333333 26.2 26 2 abnormal cytotoxic T cell physiology 0.384813497679677 0.635184854331916 0.769993820535337 0.333333333333333 26.2 26 2 abnormal epidermis stratum granulosum morphology 0.401706664107779 0.660221557296399 0.769993820535337 0.333333333333333 26.2 26 2 rectal prolapse 0.432207312387623 0.705225116145761 0.769993820535337 0.333333333333333 26.2 26 2 increased circulating total protein level 0.44437743626424 0.718018105038842 0.769993820535337 0.333333333333333 26.2 26 2 abnormal salivary gland morphology 0.458001452086655 0.729138311721955 0.769993820535337 0.333333333333333 26.2 26 2 trunk curl 0.458001452086655 0.729138311721955 0.769993820535337 0.333333333333333 26.2 26 2 increased incidence of induced tumors 0.458001452086655 0.729138311721955 0.769993820535337 0.333333333333333 26.2 26 2 hypoalgesia 0.458001452086655 0.729138311721955 0.769993820535337 0.333333333333333 26.2 26 2 abnormal retinal rod cell morphology 0.473552018737877 0.733564927250519 0.769993820535337 0.333333333333333 26.2 26 2 acidosis 0.473552018737877 0.733564927250519 0.769993820535337 0.333333333333333 26.2 26 2 increased susceptibility to autoimmune disorder 0.473552018737877 0.733564927250519 0.769993820535337 0.333333333333333 26.2 26 2 abnormal macrophage chemotaxis 0.473552018737877 0.733564927250519 0.769993820535337 0.333333333333333 26.2 26 2 impaired fertilization 0.356837721882374 0.592644877800582 0.758993908813403 0.328571428571429 26.2 26 2 dehydration 0.356837721882374 0.592644877800582 0.758993908813403 0.328571428571429 26.2 26 2 abnormal leukocyte migration 0.398495432510184 0.656896877646841 0.755186247063503 0.326923076923077 26.2 26 2 decreased body temperature 0.398495432510184 0.656896877646841 0.755186247063503 0.326923076923077 26.2 26 2 impaired macrophage phagocytosis 0.424556702451408 0.692969027131153 0.752086987499631 0.325581395348837 26.2 26 2 abnormal T cell activation 0.380267011487079 0.628097072426368 0.749183176737084 0.324324324324324 26.2 26 2 abnormal endoderm development 0.456306905325425 0.727371628963149 0.747346943460768 0.323529411764706 26.2 26 2 decreased pancreatic beta cell number 0.456306905325425 0.727371628963149 0.747346943460768 0.323529411764706 26.2 26 2 absent mature ovarian follicles 0.468702073647873 0.733564927250519 0.745155310195487 0.32258064516129 26.2 26 2 abnormal body temperature homeostasis 0.468702073647873 0.733564927250519 0.745155310195487 0.32258064516129 26.2 26 2 abnormal T cell proliferation 0.468702073647873 0.733564927250519 0.745155310195487 0.32258064516129 26.2 26 2 decreased circulating progesterone level 0.482324909435273 0.733564927250519 0.742494041230503 0.321428571428571 26.2 26 2 ruffled hair 0.497474606267246 0.733564927250519 0.739194067713923 0.32 26.2 26 2 abnormal energy expenditure 0.497474606267246 0.733564927250519 0.739194067713923 0.32 26.2 26 2 abnormal oogenesis 0.514575622032851 0.734159368974314 0.734994101420094 0.318181818181818 26.2 26 2 increased neutrophil cell number 0.375448837993698 0.620757051850664 0.732821705061217 0.317241379310345 26.2 26 2 flaky skin 0.534257365456308 0.760060163896234 0.729467829980845 0.315789473684211 26.2 26 2 decreased grooming behavior 0.534257365456308 0.760060163896234 0.729467829980845 0.315789473684211 26.2 26 2 abnormal optic vesicle formation 0.534257365456308 0.760060163896234 0.729467829980845 0.315789473684211 26.2 26 2 increased left ventricle weight 0.534257365456308 0.760060163896234 0.729467829980845 0.315789473684211 26.2 26 2 abnormal behavioral response to xenobiotic 0.534257365456308 0.760060163896234 0.729467829980845 0.315789473684211 26.2 26 2 abnormal lymphatic vessel morphology 0.515439696980685 0.735181333852897 0.721869206751878 0.3125 26.2 26 2 poor circulation 0.557507609088432 0.784167473908665 0.721869206751878 0.3125 26.2 26 2 increased circulating estradiol level 0.557507609088432 0.784167473908665 0.721869206751878 0.3125 26.2 26 2 abnormal intestinal lipid absorption 0.557507609088432 0.784167473908665 0.721869206751878 0.3125 26.2 26 2 loose skin 0.557507609088432 0.784167473908665 0.721869206751878 0.3125 26.2 26 2 decreased circulating triiodothyronine level 0.557507609088432 0.784167473908665 0.721869206751878 0.3125 26.2 26 2 decreased skeletal muscle weight 0.557507609088432 0.784167473908665 0.721869206751878 0.3125 26.2 26 2 dilated respiratory conducting tubes 0.557507609088432 0.784167473908665 0.721869206751878 0.3125 26.2 26 2 embryonic lethality between somite formation and embryo turning, incomplete penetrance 0.557507609088432 0.784167473908665 0.721869206751878 0.3125 26.2 26 2 decreased midbrain size 0.557507609088432 0.784167473908665 0.721869206751878 0.3125 26.2 26 2 abnormal intestinal epithelium morphology 0.491854551379615 0.733564927250519 0.721869206751878 0.3125 26.2 26 2 abnormal hair shaft morphology 0.491854551379615 0.733564927250519 0.721869206751878 0.3125 26.2 26 2 abnormal NK cell physiology 0.484745420567531 0.733564927250519 0.719502422467446 0.311475409836066 26.2 26 2 abnormal circulating glucose level 0.531292770718695 0.75692483800845 0.716890798429451 0.310344827586207 26.2 26 2 increased retinal apoptosis 0.531292770718695 0.75692483800845 0.716890798429451 0.310344827586207 26.2 26 2 decreased susceptibility to injury 0.497642857595835 0.733564927250519 0.713376627848915 0.308823529411765 26.2 26 2 pulmonary edema 0.548941744265873 0.774088769195782 0.710763526648003 0.307692307692308 26.2 26 2 abnormal inflammatory response 0.519070438027891 0.740147729776083 0.705827668824059 0.305555555555556 26.2 26 2 abnormal systemic arterial blood pressure 0.544746657808834 0.76839087683554 0.705827668824059 0.305555555555556 26.2 26 2 abnormal humoral immune response 0.513267858267031 0.733564927250519 0.703994350203736 0.304761904761905 26.2 26 2 blistering 0.568864430474081 0.798561100905348 0.70303783614096 0.304347826086957 26.2 26 2 pancreas inflammation 0.568864430474081 0.798561100905348 0.70303783614096 0.304347826086957 26.2 26 2 abnormal crista ampullaris morphology 0.568864430474081 0.798561100905348 0.70303783614096 0.304347826086957 26.2 26 2 decreased epididymis weight 0.568864430474081 0.798561100905348 0.70303783614096 0.304347826086957 26.2 26 2 abnormal food intake 0.529273771760817 0.754480519916924 0.70303783614096 0.304347826086957 26.2 26 2 enlarged pericardium 0.560821087677107 0.788159579433222 0.699994382304852 0.303030303030303 26.2 26 2 absent vibrissae 0.560821087677107 0.788159579433222 0.699994382304852 0.303030303030303 26.2 26 2 decreased systemic arterial blood pressure 0.560821087677107 0.788159579433222 0.699994382304852 0.303030303030303 26.2 26 2 impaired ovarian folliculogenesis 0.570975572871462 0.801298582520599 0.692994438481803 0.3 26.2 26 2 increased urine calcium level 0.591753706845017 0.815505454724088 0.692994438481803 0.3 26.2 26 2 abnormal heart electrocardiography waveform feature 0.591753706845017 0.815505454724088 0.692994438481803 0.3 26.2 26 2 salivary gland inflammation 0.578485723747476 0.808021047095744 0.692994438481803 0.3 26.2 26 2 liver hemorrhage 0.578485723747476 0.808021047095744 0.692994438481803 0.3 26.2 26 2 decreased regulatory T cell number 0.604368663656974 0.832659679228316 0.679406312237062 0.294117647058824 26.2 26 2 decreased vasoconstriction 0.61866450363883 0.852119575194678 0.679406312237062 0.294117647058824 26.2 26 2 curly vibrissae 0.620123781031074 0.853420694503346 0.67374459296842 0.291666666666667 26.2 26 2 abnormal cardiac muscle contractility 0.620123781031074 0.853420694503346 0.67374459296842 0.291666666666667 26.2 26 2 prolonged QT interval 0.620123781031074 0.853420694503346 0.67374459296842 0.291666666666667 26.2 26 2 abnormal CD8-positive, alpha beta T cell morphology 0.623397216970041 0.854145181610012 0.670639779175939 0.290322580645161 26.2 26 2 increased susceptibility to injury 0.635952627826325 0.865140002124676 0.666340806232503 0.288461538461538 26.2 26 2 abnormal intestinal goblet cell morphology 0.645700131893026 0.865140002124676 0.659994703316003 0.285714285714286 26.2 26 2 abnormal bile salt homeostasis 0.645254608748362 0.865140002124676 0.659994703316003 0.285714285714286 26.2 26 2 increased bone ossification 0.645254608748362 0.865140002124676 0.659994703316003 0.285714285714286 26.2 26 2 abnormal leukocyte adhesion 0.665625395282119 0.872132299586132 0.65153323276067 0.282051282051282 26.2 26 2 impaired natural killer cell mediated cytotoxicity 0.684959509304922 0.888803745120497 0.648415848871863 0.280701754385965 26.2 26 2 decreased heart rate variability 0.674476997831503 0.876202162353181 0.641661517112781 0.277777777777778 26.2 26 2 increased susceptibility to bacterial infection induced morbidity/mortality 0.714592809087688 0.92316261366171 0.641661517112781 0.277777777777778 26.2 26 2 increased susceptibility to parasitic infection 0.728628239989389 0.940561882186614 0.641661517112781 0.277777777777778 26.2 26 2 abnormal T-helper 1 physiology 0.699992517680271 0.905241168562347 0.638931042571875 0.276595744680851 26.2 26 2 decreased bone strength 0.687488956922242 0.891853340466273 0.637236265270623 0.275862068965517 26.2 26 2 increased activated T cell number 0.694259228766679 0.898060234819091 0.629994944074367 0.272727272727273 26.2 26 2 gastrointestinal hemorrhage 0.727126496258521 0.938866939757628 0.615995056428269 0.266666666666667 26.2 26 2 decreased cytotoxic T cell cytolysis 0.741158063903048 0.946849809700792 0.611465681013356 0.264705882352941 26.2 26 2 decreased fertilization frequency 0.724555437965502 0.935790058120034 0.607889858317371 0.263157894736842 26.2 26 2 abnormal vibrissa morphology 0.765764004394976 0.950043870789279 0.604995144706336 0.261904761904762 26.2 26 2 decreased bone ossification 0.751351971461963 0.946849809700792 0.598884082638595 0.259259259259259 26.2 26 2 autoimmune response 0.763206245576253 0.947106777685672 0.59612424815639 0.258064516129032 26.2 26 2 waved hair 0.768822681672331 0.95336312096706 0.577495365401503 0.25 26.2 26 2 abnormal circulating cytokine level 0.768822681672331 0.95336312096706 0.577495365401503 0.25 26.2 26 2 decreased ovulation rate 0.777980361522122 0.964238240800338 0.577495365401503 0.25 26.2 26 2 abnormal cellular extravasation 0.777980361522122 0.964238240800338 0.577495365401503 0.25 26.2 26 2 increased dopamine level 0.795727839460872 0.985743526224562 0.577495365401503 0.25 26.2 26 2 abnormal serotonin level 0.795727839460872 0.985743526224562 0.577495365401503 0.25 26.2 26 2 stomach inflammation 0.818665914137939 1 0.557581732111796 0.241379310344828 26.2 26 2 abnormal feces composition 0.812767628636017 1 0.554395550785442 0.24 26.2 26 2 impaired conditioned place preference behavior 0.812767628636017 1 0.554395550785442 0.24 26.2 26 2 increased acute inflammation 0.807437704461071 0.995704861827662 0.549995586096669 0.238095238095238 26.2 26 2 increased susceptibility to viral infection induced morbidity/mortality 0.85050594850858 1 0.54352504978965 0.235294117647059 26.2 26 2 intestinal ulcer 0.84072549143001 1 0.524995786728639 0.227272727272727 26.2 26 2 intestinal inflammation 0.84072549143001 1 0.524995786728639 0.227272727272727 26.2 26 2 decreased airway responsiveness 0.84072549143001 1 0.524995786728639 0.227272727272727 26.2 26 2 decreased susceptibility to viral infection induced morbidity/mortality 0.84072549143001 1 0.524995786728639 0.227272727272727 26.2 26 2 decreased inflammatory response 0.952368097903656 1 0.522495806791836 0.226190476190476 26.2 26 2 decreased susceptibility to bacterial infection induced morbidity/mortality 0.870827255294217 1 0.521608717136841 0.225806451612903 26.2 26 2 abnormal intestine physiology 0.870827255294217 1 0.521608717136841 0.225806451612903 26.2 26 2 abnormal crypts of Lieberkuhn morphology 0.891855091727553 1 0.505308444726315 0.21875 26.2 26 2 increased susceptibility to fungal infection 0.869116956716301 1 0.502169882957828 0.217391304347826 26.2 26 2 abnormal thrombosis 0.936940684851454 1 0.498231295640512 0.215686274509804 26.2 26 2 increased susceptibility to induced arthritis 0.910856551150534 1 0.477927198952968 0.206896551724138 26.2 26 2 abnormal leukocyte cell number 0.929866996276388 1 0.444227204155002 0.192307692307692 26.2 26 2 abnormal intestinal mucosa morphology 0.970915141901357 1 0.429763992856932 0.186046511627907 26.2 26 2 decreased susceptibility to induced arthritis 0.990184034019448 1 0.405259905544914 0.175438596491228 26.2 26 2 abnormal hair cycle 0.971496695719424 1 0.384996910267668 0.166666666666667 26.2 26 2 decreased susceptibility to parasitic infection 0.982265543944345 1 0.360934603375939 0.15625 26.2 26 2 abnormal positive T cell selection 2.37865494465566e-07 8.51353118680714e-06 1.97135850048174 1 26.1 26 1 heart hemorrhage 0.000488409955591713 0.00671226389245518 1.97135850048174 1 26.1 26 1 increased DN3 thymocyte number 0.000488409955591713 0.00671226389245518 1.97135850048174 1 26.1 26 1 abnormal cervical lymph node morphology 0.00145174733798613 0.0161575906185257 1.97135850048174 1 26.1 26 1 enlarged pancreas 0.00145174733798613 0.0161575906185257 1.97135850048174 1 26.1 26 1 abnormal T cell clonal deletion 0.00145174733798613 0.0161575906185257 1.97135850048174 1 26.1 26 1 thymus cortex atrophy 0.00145174733798613 0.0161575906185257 1.97135850048174 1 26.1 26 1 abnormal vertebral artery origin 0.00145174733798613 0.0161575906185257 1.97135850048174 1 26.1 26 1 small hair follicles 0.00431491569901432 0.0391014673999932 1.97135850048174 1 26.1 26 1 abnormal pineal gland morphology 0.00431491569901432 0.0391014673999932 1.97135850048174 1 26.1 26 1 increased response to stress-induced hyperthermia 0.00431491569901432 0.0391014673999932 1.97135850048174 1 26.1 26 1 aorta hypoplasia 0.00431491569901432 0.0391014673999932 1.97135850048174 1 26.1 26 1 decreased small intestinal villus height 0.00431491569901432 0.0391014673999932 1.97135850048174 1 26.1 26 1 elevated level of mitotic sister chromatid exchange 0.000164305734389877 0.00269775917026283 1.97135850048174 1 26.1 26 1 embryo cyst 0.000164305734389877 0.00269775917026283 1.97135850048174 1 26.1 26 1 abnormal thymocyte activation 1.3914865173401e-08 6.85410437996733e-07 1.87279057545765 0.95 26.1 26 1 decreased thymocyte apoptosis 2.44815572080325e-06 6.76643039499788e-05 1.83993460044962 0.933333333333333 26.1 26 1 abnormal spleen periarteriolar lymphoid sheath morphology 6.8102034088036e-06 0.00016940380979399 1.83054717901876 0.928571428571429 26.1 26 1 decreased response to antigen 6.8102034088036e-06 0.00016940380979399 1.83054717901876 0.928571428571429 26.1 26 1 abnormal vitelline vein connection 5.19042060677495e-05 0.000985585592316999 1.80707862544159 0.916666666666667 26.1 26 1 reduced sympathetic cervical ganglion size 0.000141973498382172 0.00238620998125442 1.79214409134703 0.909090909090909 26.1 26 1 absent CD4-positive, alpha beta T cells 0.000385384813428952 0.00558976515104675 1.77422265043356 0.9 26.1 26 1 increased effector memory CD4-positive, alpha-beta T cell number 1.92412047282842e-06 5.50143640938011e-05 1.75231866709488 0.888888888888889 26.1 26 1 decreased level of surface class I molecules 0.0010365852871468 0.0122785995322745 1.75231866709488 0.888888888888889 26.1 26 1 abnormal artery development 0.0010365852871468 0.0122785995322745 1.75231866709488 0.888888888888889 26.1 26 1 abnormal leukopoiesis 0.0010365852871468 0.0122785995322745 1.75231866709488 0.888888888888889 26.1 26 1 abnormal oxidative phosphorylation 0.0010365852871468 0.0122785995322745 1.75231866709488 0.888888888888889 26.1 26 1 colon polyps 0.00275713950400456 0.0275338279144105 1.72493868792152 0.875 26.1 26 1 pleural effusion 0.00275713950400456 0.0275338279144105 1.72493868792152 0.875 26.1 26 1 abnormal macrophage activation involved in immune response 0.00275713950400456 0.0275338279144105 1.72493868792152 0.875 26.1 26 1 small thymus medulla 0.00275713950400456 0.0275338279144105 1.72493868792152 0.875 26.1 26 1 increased brain apoptosis 0.00275713950400456 0.0275338279144105 1.72493868792152 0.875 26.1 26 1 increased hemangioma incidence 9.11118904890838e-05 0.00161886305422569 1.68973585755578 0.857142857142857 26.1 26 1 abnormal maternal decidual layer morphology 9.11118904890838e-05 0.00161886305422569 1.68973585755578 0.857142857142857 26.1 26 1 lysosomal protein accumulation 9.11118904890838e-05 0.00161886305422569 1.68973585755578 0.857142857142857 26.1 26 1 broad head 0.00723177163235263 0.0597642256992597 1.68973585755578 0.857142857142857 26.1 26 1 decreased activated T cell number 0.00723177163235263 0.0597642256992597 1.68973585755578 0.857142857142857 26.1 26 1 aorta coarctation 0.00723177163235263 0.0597642256992597 1.68973585755578 0.857142857142857 26.1 26 1 abnormal negative T cell selection 0.00723177163235263 0.0597642256992597 1.68973585755578 0.857142857142857 26.1 26 1 decreased tidal volume 0.00723177163235263 0.0597642256992597 1.68973585755578 0.857142857142857 26.1 26 1 absent popliteal lymph nodes 0.00723177163235263 0.0597642256992597 1.68973585755578 0.857142857142857 26.1 26 1 abnormal spinal cord central canal morphology 0.00723177163235263 0.0597642256992597 1.68973585755578 0.857142857142857 26.1 26 1 increased tumor latency 0.00723177163235263 0.0597642256992597 1.68973585755578 0.857142857142857 26.1 26 1 decreased DN2 thymocyte number 0.00723177163235263 0.0597642256992597 1.68973585755578 0.857142857142857 26.1 26 1 decreased DN4 thymocyte number 0.00723177163235263 0.0597642256992597 1.68973585755578 0.857142857142857 26.1 26 1 arteritis 0.00723177163235263 0.0597642256992597 1.68973585755578 0.857142857142857 26.1 26 1 decreased T-helper 17 cell number 0.00723177163235263 0.0597642256992597 1.68973585755578 0.857142857142857 26.1 26 1 decreased CD8-positive, naive alpha-beta T cell number 0.00723177163235263 0.0597642256992597 1.68973585755578 0.857142857142857 26.1 26 1 ductus venosus stenosis 0.00723177163235263 0.0597642256992597 1.68973585755578 0.857142857142857 26.1 26 1 abnormal Mullerian duct topology 0.00723177163235263 0.0597642256992597 1.68973585755578 0.857142857142857 26.1 26 1 abnormal T cell subpopulation ratio 1.87348542142662e-09 1.10959404423779e-07 1.67266781859057 0.848484848484849 26.1 26 1 increased fibroblast apoptosis 4.74555275756176e-09 2.56620923574671e-07 1.66333373478147 0.84375 26.1 26 1 decreased double-positive T cell number 3.3179084973159e-25 1.50059952492242e-22 1.65594114040466 0.84 26.1 26 1 abnormal T cell proliferation 1.19556936204685e-08 6.00803795574048e-07 1.65339745201694 0.838709677419355 26.1 26 1 abnormal thymus cortex morphology 2.10095245556609e-05 0.000456429627355515 1.64279875040145 0.833333333333333 26.1 26 1 decreased cellular sensitivity to gamma-irradiation 2.10095245556609e-05 0.000456429627355515 1.64279875040145 0.833333333333333 26.1 26 1 abnormal cytotoxic T cell physiology 4.59591381421079e-11 3.51764172703056e-09 1.64279875040145 0.833333333333333 26.1 26 1 abnormal thymus involution 0.000592319959954289 0.00809558187025436 1.64279875040145 0.833333333333333 26.1 26 1 echinocytosis 0.0186307575041553 0.12006220023727 1.64279875040145 0.833333333333333 26.1 26 1 absent ectoplacental cone 0.0186307575041553 0.12006220023727 1.64279875040145 0.833333333333333 26.1 26 1 delayed brain development 0.0186307575041553 0.12006220023727 1.64279875040145 0.833333333333333 26.1 26 1 abnormal lymph node cortex morphology 0.0186307575041553 0.12006220023727 1.64279875040145 0.833333333333333 26.1 26 1 increased post-tetanic potentiation 0.0186307575041553 0.12006220023727 1.64279875040145 0.833333333333333 26.1 26 1 rheumatoid arthritis 0.0186307575041553 0.12006220023727 1.64279875040145 0.833333333333333 26.1 26 1 abnormal leukocyte tethering or rolling 0.0186307575041553 0.12006220023727 1.64279875040145 0.833333333333333 26.1 26 1 abnormal cholesterol level 0.0186307575041553 0.12006220023727 1.64279875040145 0.833333333333333 26.1 26 1 absent cochlear nerve compound action potential 0.0186307575041553 0.12006220023727 1.64279875040145 0.833333333333333 26.1 26 1 abnormal immature B cell morphology 0.0186307575041553 0.12006220023727 1.64279875040145 0.833333333333333 26.1 26 1 impaired granulocyte bactericidal activity 0.0186307575041553 0.12006220023727 1.64279875040145 0.833333333333333 26.1 26 1 abnormal heart size 0.0186307575041553 0.12006220023727 1.64279875040145 0.833333333333333 26.1 26 1 decreased DN1 thymic pro-T cell number 0.0186307575041553 0.12006220023727 1.64279875040145 0.833333333333333 26.1 26 1 myocardium hypoplasia 0.0186307575041553 0.12006220023727 1.64279875040145 0.833333333333333 26.1 26 1 additional anastomosis between intracranial vertebral arteries 0.0186307575041553 0.12006220023727 1.64279875040145 0.833333333333333 26.1 26 1 decreased tear production 0.0186307575041553 0.12006220023727 1.64279875040145 0.833333333333333 26.1 26 1 decreased retinal apoptosis 0.0186307575041553 0.12006220023727 1.64279875040145 0.833333333333333 26.1 26 1 subcutaneous edema 1.84360534783496e-07 6.95588611164629e-06 1.61933019682428 0.821428571428571 26.1 26 1 increased B cell derived lymphoma incidence 2.73387448545503e-12 2.72020511302776e-10 1.61651397039502 0.82 26.1 26 1 increased double-negative T cell number 1.09290503216696e-14 1.55348643858019e-12 1.61586762334569 0.819672131147541 26.1 26 1 abnormal sphenoid bone morphology 0.00148073573113946 0.0164434380857563 1.61292968221233 0.818181818181818 26.1 26 1 arrested T cell differentiation 2.52964604192863e-07 8.92552415503188e-06 1.57708680038539 0.8 26.1 26 1 spleen atrophy 2.85768480315514e-05 0.00057792609332101 1.57708680038539 0.8 26.1 26 1 heterochrony 0.000314905398922196 0.00469058191508361 1.57708680038539 0.8 26.1 26 1 absent inguinal lymph nodes 0.00364138718201815 0.0346384344752205 1.57708680038539 0.8 26.1 26 1 decreased transitional stage T2 B cell number 0.00364138718201815 0.0346384344752205 1.57708680038539 0.8 26.1 26 1 acanthocytosis 0.00364138718201815 0.0346384344752205 1.57708680038539 0.8 26.1 26 1 abnormal left subclavian artery morphology 0.00364138718201815 0.0346384344752205 1.57708680038539 0.8 26.1 26 1 abnormal inferior vena cava valve morphology 0.00364138718201815 0.0346384344752205 1.57708680038539 0.8 26.1 26 1 thick aortic valve cusps 0.00364138718201815 0.0346384344752205 1.57708680038539 0.8 26.1 26 1 abnormal B cell differentiation 6.80390891003995e-19 1.53861121942949e-16 1.55975617620533 0.791208791208791 26.1 26 1 decreased tumor incidence 6.85119503962274e-05 0.00124852363817301 1.55633565827506 0.789473684210526 26.1 26 1 increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 6.85119503962274e-05 0.00124852363817301 1.55633565827506 0.789473684210526 26.1 26 1 vascular smooth muscle hypoplasia 0.000756449245474778 0.0100481028915643 1.54892453609279 0.785714285714286 26.1 26 1 abnormal T cell activation 3.78247911669332e-15 6.07026890501589e-13 1.5451188247019 0.783783783783784 26.1 26 1 thymus hypoplasia 6.69798686433424e-27 4.16531058125786e-24 1.54280230472484 0.782608695652174 26.1 26 1 abnormal thymus medulla morphology 0.000162254569767468 0.00269072161531051 1.53327883370802 0.777777777777778 26.1 26 1 abnormal Peyer's patch follicle morphology 0.000162254569767468 0.00269072161531051 1.53327883370802 0.777777777777778 26.1 26 1 abnormal hypoglossal nerve topology 0.000162254569767468 0.00269072161531051 1.53327883370802 0.777777777777778 26.1 26 1 abnormal gut-associated lymphoid tissue morphology 0.00877907926300677 0.069326856084855 1.53327883370802 0.777777777777778 26.1 26 1 absent cervical lymph nodes 0.00877907926300677 0.069326856084855 1.53327883370802 0.777777777777778 26.1 26 1 abnormal telomere morphology 0.00877907926300677 0.069326856084855 1.53327883370802 0.777777777777778 26.1 26 1 decreased effector memory CD4-positive, alpha-beta T cell number 0.00877907926300677 0.069326856084855 1.53327883370802 0.777777777777778 26.1 26 1 abnormal ductus venosus valve topology 0.00877907926300677 0.069326856084855 1.53327883370802 0.777777777777778 26.1 26 1 abnormal infrahyoid muscle connection 0.00877907926300677 0.069326856084855 1.53327883370802 0.777777777777778 26.1 26 1 symmetric azygos veins 0.00877907926300677 0.069326856084855 1.53327883370802 0.777777777777778 26.1 26 1 abnormal CD8-positive, alpha beta T cell morphology 7.60575716979539e-07 2.37978879998315e-05 1.52621303263102 0.774193548387097 26.1 26 1 abnormal T cell differentiation 3.40855787869278e-19 8.07503592690313e-17 1.52243527759976 0.772277227722772 26.1 26 1 increased thymocyte apoptosis 7.8726034491503e-06 0.000189208706084651 1.51642961575518 0.769230769230769 26.1 26 1 lymphoid hypoplasia 0.00178777255699138 0.0193351488500698 1.51642961575518 0.769230769230769 26.1 26 1 abnormal telomere length 0.00178777255699138 0.0193351488500698 1.51642961575518 0.769230769230769 26.1 26 1 decreased cytotoxic T cell cytolysis 3.97708123483135e-07 1.31032974458847e-05 1.50750944154486 0.764705882352941 26.1 26 1 abnormal interatrial septum morphology 0.000379030951999912 0.00552985039941221 1.50750944154486 0.764705882352941 26.1 26 1 abnormal embryonic-extraembryonic boundary morphology 0.000379030951999912 0.00552985039941221 1.50750944154486 0.764705882352941 26.1 26 1 abnormal ectoplacental cone morphology 0.000379030951999912 0.00552985039941221 1.50750944154486 0.764705882352941 26.1 26 1 increased B cell proliferation 2.51150146150702e-11 1.98328885253928e-09 1.50357851731658 0.76271186440678 26.1 26 1 abnormal spleen white pulp morphology 2.05664028448562e-08 9.38695909662014e-07 1.50198742893847 0.761904761904762 26.1 26 1 abnormal lymphocyte physiology 4.70495665298168e-09 2.56620923574671e-07 1.49994668514915 0.760869565217391 26.1 26 1 increased cellular sensitivity to ionizing radiation 1.81526395397881e-05 0.000403166882635919 1.49823246036612 0.76 26.1 26 1 increased mortality induced by gamma-irradiation 4.04884245220459e-06 0.000107143570211265 1.49551334519304 0.758620689655172 26.1 26 1 abnormal chromosome morphology 2.06096167973862e-07 7.53917967404384e-06 1.49183886522942 0.756756756756757 26.1 26 1 small gonad 0.000188317257490255 0.00305533687676712 1.4785188753613 0.75 26.1 26 1 abnormal Peyer's patch T cell area morphology 0.000188317257490255 0.00305533687676712 1.4785188753613 0.75 26.1 26 1 decreased T cell proliferation 8.0090467076015e-25 3.0650005669475e-22 1.4785188753613 0.75 26.1 26 1 increased hemangiosarcoma incidence 4.138687385962e-05 0.000817062291474641 1.4785188753613 0.75 26.1 26 1 interstitial pneumonia 0.00414598304469498 0.038164838491815 1.4785188753613 0.75 26.1 26 1 altered tumor susceptibility 0.00414598304469498 0.038164838491815 1.4785188753613 0.75 26.1 26 1 abnormal vascular endothelial cell development 0.00414598304469498 0.038164838491815 1.4785188753613 0.75 26.1 26 1 increased osteosarcoma incidence 0.00414598304469498 0.038164838491815 1.4785188753613 0.75 26.1 26 1 decreased red blood cell distribution width 0.00414598304469498 0.038164838491815 1.4785188753613 0.75 26.1 26 1 increased fibrosarcoma incidence 0.00414598304469498 0.038164838491815 1.4785188753613 0.75 26.1 26 1 persistent right dorsal aorta 0.00414598304469498 0.038164838491815 1.4785188753613 0.75 26.1 26 1 abnormal pulmonary valve cusp morphology 0.00414598304469498 0.038164838491815 1.4785188753613 0.75 26.1 26 1 embryonic lethality between implantation and placentation, incomplete penetrance 0.00414598304469498 0.038164838491815 1.4785188753613 0.75 26.1 26 1 increased intestinal adenocarcinoma incidence 0.000871864736462974 0.0111504551771293 1.4785188753613 0.75 26.1 26 1 decreased liver cholesterol level 0.000871864736462974 0.0111504551771293 1.4785188753613 0.75 26.1 26 1 abnormal bone marrow development 0.0206556680173968 0.126158229015468 1.4785188753613 0.75 26.1 26 1 schistocytosis 0.0206556680173968 0.126158229015468 1.4785188753613 0.75 26.1 26 1 abnormal cecum morphology 0.0206556680173968 0.126158229015468 1.4785188753613 0.75 26.1 26 1 abnormal soft palate morphology 0.0206556680173968 0.126158229015468 1.4785188753613 0.75 26.1 26 1 increased cardiac output 0.0206556680173968 0.126158229015468 1.4785188753613 0.75 26.1 26 1 lymph node inflammation 0.0206556680173968 0.126158229015468 1.4785188753613 0.75 26.1 26 1 abnormal extraembryonic tissue physiology 0.0206556680173968 0.126158229015468 1.4785188753613 0.75 26.1 26 1 abnormal kidney epithelium morphology 0.0206556680173968 0.126158229015468 1.4785188753613 0.75 26.1 26 1 accumulation of giant lysosomes in kidney/renal tubule cells 0.0206556680173968 0.126158229015468 1.4785188753613 0.75 26.1 26 1 abnormal NK cell morphology 0.0206556680173968 0.126158229015468 1.4785188753613 0.75 26.1 26 1 enlarged inguinal lymph nodes 0.0206556680173968 0.126158229015468 1.4785188753613 0.75 26.1 26 1 abnormal mitotic spindle assembly checkpoint 0.0206556680173968 0.126158229015468 1.4785188753613 0.75 26.1 26 1 abnormal base-excision repair 0.0206556680173968 0.126158229015468 1.4785188753613 0.75 26.1 26 1 abnormal cerebellum deep nucleus morphology 0.0206556680173968 0.126158229015468 1.4785188753613 0.75 26.1 26 1 increased caudal vertebrae number 0.0206556680173968 0.126158229015468 1.4785188753613 0.75 26.1 26 1 abnormal hepatic vein morphology 0.0206556680173968 0.126158229015468 1.4785188753613 0.75 26.1 26 1 increased heart right ventricle size 0.0206556680173968 0.126158229015468 1.4785188753613 0.75 26.1 26 1 lung situs inversus 0.0206556680173968 0.126158229015468 1.4785188753613 0.75 26.1 26 1 increased aorta wall thickness 0.0206556680173968 0.126158229015468 1.4785188753613 0.75 26.1 26 1 increased testis apoptosis 0.0206556680173968 0.126158229015468 1.4785188753613 0.75 26.1 26 1 retropleural edema 0.0206556680173968 0.126158229015468 1.4785188753613 0.75 26.1 26 1 abnormal umbilical vein topology 0.0206556680173968 0.126158229015468 1.4785188753613 0.75 26.1 26 1 abnormal cell cycle 2.03969853148617e-19 5.3407895758651e-17 1.47423331340373 0.747826086956522 26.1 26 1 decreased B cell proliferation 1.0113434183565e-13 1.18064661425311e-11 1.47228039909396 0.746835443037975 26.1 26 1 increased cellular sensitivity to gamma-irradiation 1.24368035298405e-08 6.18730975609564e-07 1.46803292589066 0.74468085106383 26.1 26 1 failure to gastrulate 2.7716421863754e-08 1.25353817065615e-06 1.45709106557346 0.739130434782609 26.1 26 1 failure of embryo implantation 9.32053306650343e-05 0.00164431390091683 1.45709106557346 0.739130434782609 26.1 26 1 increased T cell proliferation 2.14525235301662e-17 4.44692935677404e-15 1.45548898633698 0.738317757009346 26.1 26 1 decreased regulatory T cell number 2.33521896746398e-06 6.56368043114876e-05 1.44952830917775 0.735294117647059 26.1 26 1 increased T cell derived lymphoma incidence 1.40954407159819e-08 6.87498211392254e-07 1.44834502076209 0.73469387755102 26.1 26 1 abnormal lymph node B cell domain morphology 0.00197069482349437 0.0209491597155652 1.44566290035327 0.733333333333333 26.1 26 1 abnormal dendritic cell morphology 0.00197069482349437 0.0209491597155652 1.44566290035327 0.733333333333333 26.1 26 1 abnormal cell differentiation 2.6755890113693e-07 9.3084303017918e-06 1.44245743937688 0.731707317073171 26.1 26 1 decreased Peyer's patch number 4.60555946429479e-05 0.000902073162790023 1.44060813496742 0.730769230769231 26.1 26 1 abnormal mesenteric lymph node morphology 0.000207092585294591 0.00333425764349705 1.43371527307763 0.727272727272727 26.1 26 1 delayed hepatic development 0.00940312438436134 0.0727917713530801 1.43371527307763 0.727272727272727 26.1 26 1 loss of cortex neurons 0.00940312438436134 0.0727917713530801 1.43371527307763 0.727272727272727 26.1 26 1 pharyngeal arch hypoplasia 0.00940312438436134 0.0727917713530801 1.43371527307763 0.727272727272727 26.1 26 1 increased glycogen level 0.00940312438436134 0.0727917713530801 1.43371527307763 0.727272727272727 26.1 26 1 abnormal CD8-positive, alpha-beta T cell physiology 2.27456902490826e-05 0.000485313963643609 1.42753546586609 0.724137931034483 26.1 26 1 increased double-positive T cell number 2.27456902490826e-05 0.000485313963643609 1.42753546586609 0.724137931034483 26.1 26 1 abnormal erythropoiesis 5.54446147846023e-16 9.85131994833558e-14 1.42688805749154 0.723809523809524 26.1 26 1 underdeveloped hair follicles 0.000942649545804264 0.0116949663101651 1.42375891701459 0.722222222222222 26.1 26 1 abnormal redox activity 0.000942649545804264 0.0116949663101651 1.42375891701459 0.722222222222222 26.1 26 1 increased effector memory CD8-positive, alpha-beta T cell number 0.000942649545804264 0.0116949663101651 1.42375891701459 0.722222222222222 26.1 26 1 spontaneous skin ulceration 0.000101132047824902 0.00177159133073552 1.41937812034685 0.72 26.1 26 1 abnormal spongiotrophoblast layer morphology 1.1234270378852e-05 0.000259955791324599 1.41691392222125 0.71875 26.1 26 1 abnormal CD4-positive, alpha-beta T cell physiology 5.49832849601742e-11 4.14457337389192e-09 1.41604624682491 0.71830985915493 26.1 26 1 small liver 6.51268013918487e-12 5.78581851650799e-10 1.41533430803817 0.717948717948718 26.1 26 1 abnormal antigen presentation 0.00436608083578289 0.0391373912757115 1.40811321462981 0.714285714285714 26.1 26 1 abnormal vascular endothelial cell migration 0.00436608083578289 0.0391373912757115 1.40811321462981 0.714285714285714 26.1 26 1 increased pulmonary respiratory rate 0.00436608083578289 0.0391373912757115 1.40811321462981 0.714285714285714 26.1 26 1 testis degeneration 0.00436608083578289 0.0391373912757115 1.40811321462981 0.714285714285714 26.1 26 1 multiple persisting craniopharyngeal ducts 0.00436608083578289 0.0391373912757115 1.40811321462981 0.714285714285714 26.1 26 1 abnormal vitelline vein topology 0.00436608083578289 0.0391373912757115 1.40811321462981 0.714285714285714 26.1 26 1 asymmetric rib joints 0.047128222183662 0.218715396794513 1.40811321462981 0.714285714285714 26.1 26 1 cellular necrosis 0.047128222183662 0.218715396794513 1.40811321462981 0.714285714285714 26.1 26 1 prostate gland epithelial hyperplasia 0.047128222183662 0.218715396794513 1.40811321462981 0.714285714285714 26.1 26 1 absent epidermis stratum corneum 0.047128222183662 0.218715396794513 1.40811321462981 0.714285714285714 26.1 26 1 abnormal lacrimal gland morphology 0.047128222183662 0.218715396794513 1.40811321462981 0.714285714285714 26.1 26 1 abnormal tumor incidence 0.047128222183662 0.218715396794513 1.40811321462981 0.714285714285714 26.1 26 1 abnormal gastrulation movements 0.047128222183662 0.218715396794513 1.40811321462981 0.714285714285714 26.1 26 1 abnormal brain ventricular system morphology 0.047128222183662 0.218715396794513 1.40811321462981 0.714285714285714 26.1 26 1 decreased mortality induced by ionizing radiation 0.047128222183662 0.218715396794513 1.40811321462981 0.714285714285714 26.1 26 1 abnormal sinus venosus morphology 0.047128222183662 0.218715396794513 1.40811321462981 0.714285714285714 26.1 26 1 abnormal MHC II cell surface expression on macrophages 0.047128222183662 0.218715396794513 1.40811321462981 0.714285714285714 26.1 26 1 increased chronic myelocytic leukemia incidence 0.047128222183662 0.218715396794513 1.40811321462981 0.714285714285714 26.1 26 1 increased keratinocyte apoptosis 0.047128222183662 0.218715396794513 1.40811321462981 0.714285714285714 26.1 26 1 abnormal sperm annulus morphology 0.047128222183662 0.218715396794513 1.40811321462981 0.714285714285714 26.1 26 1 increased compact bone volume 0.047128222183662 0.218715396794513 1.40811321462981 0.714285714285714 26.1 26 1 increased circulating lactate dehydrogenase level 0.047128222183662 0.218715396794513 1.40811321462981 0.714285714285714 26.1 26 1 small tail bud 0.047128222183662 0.218715396794513 1.40811321462981 0.714285714285714 26.1 26 1 decreased areal bone mineral density 0.047128222183662 0.218715396794513 1.40811321462981 0.714285714285714 26.1 26 1 absent connection between subcutaneous lymph vessels and lymph sac 0.047128222183662 0.218715396794513 1.40811321462981 0.714285714285714 26.1 26 1 increased incidence of induced tumors 0.000453365533035893 0.00635350289254526 1.40811321462981 0.714285714285714 26.1 26 1 decreased bone marrow cell number 5.94477623728964e-11 4.41421817619641e-09 1.40425537020617 0.712328767123288 26.1 26 1 liver hypoplasia 3.65834435959939e-08 1.63966335036099e-06 1.40269739457354 0.711538461538462 26.1 26 1 autoimmune response 2.42442688242804e-05 0.000504666265275294 1.3990286132451 0.709677419354839 26.1 26 1 inner cell mass degeneration 2.42442688242804e-05 0.000504666265275294 1.3990286132451 0.709677419354839 26.1 26 1 abnormal lymph node morphology 1.56758383984173e-07 6.14073197103354e-06 1.39637893784123 0.708333333333333 26.1 26 1 thymus atrophy 1.56758383984173e-07 6.14073197103354e-06 1.39637893784123 0.708333333333333 26.1 26 1 small lymph nodes 0.000219050154335327 0.00343777450415853 1.39637893784123 0.708333333333333 26.1 26 1 failure of chorioallantoic fusion 7.79715558520354e-08 3.31545718259723e-06 1.39154717681064 0.705882352941177 26.1 26 1 pancytopenia 0.00205466581917433 0.0215806313289563 1.39154717681064 0.705882352941177 26.1 26 1 abnormal fetal cardiomyocyte proliferation 0.000106248042336575 0.00183536114800159 1.38725227811678 0.703703703703704 26.1 26 1 embryonic lethality between somite formation and embryo turning, complete penetrance 5.66153703024691e-10 3.56608603124978e-08 1.37995095033722 0.7 26.1 26 1 abnormal optic cup morphology 5.17039697403912e-05 0.00098554501708217 1.37995095033722 0.7 26.1 26 1 increased skin tumor incidence 0.000976372745879215 0.0117897078720392 1.37995095033722 0.7 26.1 26 1 absent ductus venosus valve 0.000976372745879215 0.0117897078720392 1.37995095033722 0.7 26.1 26 1 abnormal mammary gland physiology 0.0207670274519802 0.126158229015468 1.37995095033722 0.7 26.1 26 1 bifid ureter 0.0207670274519802 0.126158229015468 1.37995095033722 0.7 26.1 26 1 abnormal gas homeostasis 0.0207670274519802 0.126158229015468 1.37995095033722 0.7 26.1 26 1 absent axillary lymph nodes 0.0207670274519802 0.126158229015468 1.37995095033722 0.7 26.1 26 1 increased circulating fructosamine level 0.0207670274519802 0.126158229015468 1.37995095033722 0.7 26.1 26 1 thin ventricle myocardium compact layer 0.0207670274519802 0.126158229015468 1.37995095033722 0.7 26.1 26 1 abnormal adaptive thermogenesis 0.0207670274519802 0.126158229015468 1.37995095033722 0.7 26.1 26 1 lethality during fetal growth through weaning, complete penetrance 0.0207670274519802 0.126158229015468 1.37995095033722 0.7 26.1 26 1 increased fatty acid oxidation 0.0207670274519802 0.126158229015468 1.37995095033722 0.7 26.1 26 1 pale yolk sac 1.68220162662882e-11 1.37195952335711e-09 1.37757581961374 0.698795180722892 26.1 26 1 decreased T cell number 1.28726845150498e-20 3.7671532624925e-18 1.37137982642208 0.695652173913043 26.1 26 1 abnormal cell death 7.00488708697149e-07 2.23393033703097e-05 1.37137982642208 0.695652173913043 26.1 26 1 embryonic lethality between implantation and placentation, complete penetrance 7.00488708697149e-07 2.23393033703097e-05 1.37137982642208 0.695652173913043 26.1 26 1 abnormal B cell morphology 0.000467406310162145 0.00650805013950737 1.37137982642208 0.695652173913043 26.1 26 1 spleen hypoplasia 6.33026500521037e-14 7.8732671002304e-12 1.37056352890635 0.695238095238095 26.1 26 1 spleen hyperplasia 2.94542127359166e-10 1.95379611148247e-08 1.366808560334 0.693333333333333 26.1 26 1 abnormal placenta vasculature 1.71094808428129e-07 6.59842381341042e-06 1.36478665417966 0.692307692307692 26.1 26 1 increased leukemia incidence 0.000225054067484299 0.00350985575465325 1.36478665417966 0.692307692307692 26.1 26 1 short premaxilla 0.00945195664202809 0.0727917713530801 1.36478665417966 0.692307692307692 26.1 26 1 abnormal grip strength 0.00945195664202809 0.0727917713530801 1.36478665417966 0.692307692307692 26.1 26 1 abnormal tail bud morphology 0.00945195664202809 0.0727917713530801 1.36478665417966 0.692307692307692 26.1 26 1 abnormal coping response 0.00945195664202809 0.0727917713530801 1.36478665417966 0.692307692307692 26.1 26 1 lordosis 0.000108868431615925 0.00186980231882994 1.35955758653913 0.689655172413793 26.1 26 1 abnormal definitive hematopoiesis 4.52874154099732e-12 4.3327863781657e-10 1.35663380678313 0.688172043010753 26.1 26 1 abnormal embryonic hematopoiesis 5.28662654042229e-05 0.000996248751462156 1.35530896908119 0.6875 26.1 26 1 increased carcinoma incidence 2.57538943720225e-05 0.000527265944447785 1.35178868604462 0.685714285714286 26.1 26 1 increased malignant tumor incidence 0.0020648001030318 0.0215806313289563 1.34882423717172 0.684210526315789 26.1 26 1 increased susceptibility to ischemic brain injury 0.0020648001030318 0.0215806313289563 1.34882423717172 0.684210526315789 26.1 26 1 decreased susceptibility to weight gain 0.0020648001030318 0.0215806313289563 1.34882423717172 0.684210526315789 26.1 26 1 abnormal abdominal fat pad morphology 0.000981093278195827 0.0117897078720392 1.34410806851028 0.681818181818182 26.1 26 1 abnormal germ layer development 0.000981093278195827 0.0117897078720392 1.34410806851028 0.681818181818182 26.1 26 1 abnormal oogenesis 0.000981093278195827 0.0117897078720392 1.34410806851028 0.681818181818182 26.1 26 1 increased skin papilloma incidence 0.000981093278195827 0.0117897078720392 1.34410806851028 0.681818181818182 26.1 26 1 abnormal lysosome physiology 0.000981093278195827 0.0117897078720392 1.34410806851028 0.681818181818182 26.1 26 1 abnormal vascular branching morphogenesis 0.000981093278195827 0.0117897078720392 1.34410806851028 0.681818181818182 26.1 26 1 increased adenoma incidence 0.000981093278195827 0.0117897078720392 1.34410806851028 0.681818181818182 26.1 26 1 impaired humoral immune response 0.000981093278195827 0.0117897078720392 1.34410806851028 0.681818181818182 26.1 26 1 abnormal T-helper 1 physiology 1.4849632365388e-06 4.38996221612402e-05 1.34220153224289 0.680851063829787 26.1 26 1 enlarged spleen 6.27290175243839e-33 4.45824088834014e-30 1.34161897949452 0.680555555555556 26.1 26 1 increased pre-B cell number 0.000469626130669979 0.00650805013950737 1.34052378032758 0.68 26.1 26 1 decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 0.000469626130669979 0.00650805013950737 1.34052378032758 0.68 26.1 26 1 decreased B cell number 7.62687350549058e-24 2.71026397784397e-21 1.33975820421089 0.679611650485437 26.1 26 1 premature aging 0.000226105541288597 0.00351523458722116 1.33770755389832 0.678571428571429 26.1 26 1 increased tumor incidence 9.03645415542348e-15 1.34662377353698e-12 1.33543640355214 0.67741935483871 26.1 26 1 decreased double-negative T cell number 0.000109369341664223 0.00186980231882994 1.33543640355214 0.67741935483871 26.1 26 1 abnormal spleen red pulp morphology 5.31059927519517e-05 0.00099698986392815 1.33356604444353 0.676470588235294 26.1 26 1 pale liver 2.61620346823574e-09 1.48052278287106e-07 1.33199898681198 0.675675675675676 26.1 26 1 abnormal cell morphology 1.47769223426217e-13 1.6707997421487e-11 1.33153161874644 0.675438596491228 26.1 26 1 increased sarcoma incidence 1.49126354678384e-06 4.38996221612402e-05 1.32764960236525 0.673469387755102 26.1 26 1 abnormal T-helper 2 physiology 3.61723807356112e-07 1.19971729439777e-05 1.32618662759681 0.672727272727273 26.1 26 1 decreased lymphocyte cell number 9.20305694477536e-15 1.34662377353698e-12 1.32450649251117 0.671875 26.1 26 1 astrocytosis 5.29530442755991e-09 2.802568034799e-07 1.32324063730966 0.671232876712329 26.1 26 1 increased monocyte cell number 9.77805782670976e-12 8.38721339446225e-10 1.32081019532276 0.67 26.1 26 1 increased embryonic tissue cell apoptosis 2.61881416869656e-09 1.48052278287106e-07 1.31423900032116 0.666666666666667 26.1 26 1 incomplete embryo turning 3.59947906153814e-07 1.19971729439777e-05 1.31423900032116 0.666666666666667 26.1 26 1 impaired hematopoiesis 1.48247226885053e-06 4.38996221612402e-05 1.31423900032116 0.666666666666667 26.1 26 1 increased autoantibody level 2.56391257479423e-05 0.000527085333041376 1.31423900032116 0.666666666666667 26.1 26 1 decreased B-1 B cell number 2.56391257479423e-05 0.000527085333041376 1.31423900032116 0.666666666666667 26.1 26 1 abnormal lysosome morphology 5.25761260522432e-05 0.00099454839205289 1.31423900032116 0.666666666666667 26.1 26 1 abnormal tumor morphology 0.000964118621815786 0.0117897078720392 1.31423900032116 0.666666666666667 26.1 26 1 abnormal inner cell mass apoptosis 0.000964118621815786 0.0117897078720392 1.31423900032116 0.666666666666667 26.1 26 1 increased circulating glycerol level 0.00427869836591445 0.0391014673999932 1.31423900032116 0.666666666666667 26.1 26 1 increased susceptibility to autoimmune disorder 0.00427869836591445 0.0391014673999932 1.31423900032116 0.666666666666667 26.1 26 1 increased papilloma incidence 0.019917407063694 0.126158229015468 1.31423900032116 0.666666666666667 26.1 26 1 increased growth rate 0.019917407063694 0.126158229015468 1.31423900032116 0.666666666666667 26.1 26 1 abnormal fatty acid level 0.019917407063694 0.126158229015468 1.31423900032116 0.666666666666667 26.1 26 1 prenatal growth retardation 0.019917407063694 0.126158229015468 1.31423900032116 0.666666666666667 26.1 26 1 heart hyperplasia 0.0444088455261768 0.218715396794513 1.31423900032116 0.666666666666667 26.1 26 1 distorted hair follicle pattern 0.0444088455261768 0.218715396794513 1.31423900032116 0.666666666666667 26.1 26 1 crypts of Lieberkuhn abscesses 0.0444088455261768 0.218715396794513 1.31423900032116 0.666666666666667 26.1 26 1 abnormal vomeronasal organ morphology 0.0444088455261768 0.218715396794513 1.31423900032116 0.666666666666667 26.1 26 1 abnormal NMDA-mediated synaptic currents 0.0444088455261768 0.218715396794513 1.31423900032116 0.666666666666667 26.1 26 1 decreased fear-related response 0.0444088455261768 0.218715396794513 1.31423900032116 0.666666666666667 26.1 26 1 abnormal thymus physiology 0.0444088455261768 0.218715396794513 1.31423900032116 0.666666666666667 26.1 26 1 decreased cellular sensitivity to ionizing radiation 0.0444088455261768 0.218715396794513 1.31423900032116 0.666666666666667 26.1 26 1 abnormal inguinal fat pad morphology 0.0444088455261768 0.218715396794513 1.31423900032116 0.666666666666667 26.1 26 1 abnormal liver vasculature morphology 0.0444088455261768 0.218715396794513 1.31423900032116 0.666666666666667 26.1 26 1 decreased transitional stage T1 B cell number 0.0444088455261768 0.218715396794513 1.31423900032116 0.666666666666667 26.1 26 1 abnormal ventricle myocardium morphology 0.0444088455261768 0.218715396794513 1.31423900032116 0.666666666666667 26.1 26 1 shortened ST segment 0.0444088455261768 0.218715396794513 1.31423900032116 0.666666666666667 26.1 26 1 decreased susceptibility to parasitic infection induced morbidity/mortality 0.0444088455261768 0.218715396794513 1.31423900032116 0.666666666666667 26.1 26 1 increased core body temperature 0.0444088455261768 0.218715396794513 1.31423900032116 0.666666666666667 26.1 26 1 increased myeloid cell number 0.0444088455261768 0.218715396794513 1.31423900032116 0.666666666666667 26.1 26 1 increased cardiac muscle glycogen level 0.0444088455261768 0.218715396794513 1.31423900032116 0.666666666666667 26.1 26 1 decreased fatty acid oxidation 0.0444088455261768 0.218715396794513 1.31423900032116 0.666666666666667 26.1 26 1 cerebellum atrophy 0.0444088455261768 0.218715396794513 1.31423900032116 0.666666666666667 26.1 26 1 decreased platelet dense granule number 0.0444088455261768 0.218715396794513 1.31423900032116 0.666666666666667 26.1 26 1 absent mesoderm 1.77684035061304e-07 6.79983134176912e-06 1.31423900032116 0.666666666666667 26.1 26 1 abnormal spleen marginal zone morphology 0.000223197355366993 0.00349184541808425 1.31423900032116 0.666666666666667 26.1 26 1 abnormal eye muscle morphology 0.000462666117779747 0.00646562903357933 1.31423900032116 0.666666666666667 26.1 26 1 liver degeneration 0.00202238717156587 0.0213617328631426 1.31423900032116 0.666666666666667 26.1 26 1 absent segment of posterior cerebral artery 0.00202238717156587 0.0213617328631426 1.31423900032116 0.666666666666667 26.1 26 1 increased muscle cell glucose uptake 0.00202238717156587 0.0213617328631426 1.31423900032116 0.666666666666667 26.1 26 1 macrocytosis 0.00915685286035992 0.0714033589032768 1.31423900032116 0.666666666666667 26.1 26 1 decreased hepatocyte number 0.00915685286035992 0.0714033589032768 1.31423900032116 0.666666666666667 26.1 26 1 delayed intramembranous bone ossification 0.00915685286035992 0.0714033589032768 1.31423900032116 0.666666666666667 26.1 26 1 immune system phenotype 0.00915685286035992 0.0714033589032768 1.31423900032116 0.666666666666667 26.1 26 1 preweaning lethality, complete penetrance 1.48063162646561e-74 7.3661423416664e-71 1.30535900707575 0.662162162162162 26.1 26 1 abnormal angiogenesis 1.05463423078352e-08 5.35388295729389e-07 1.30535900707575 0.662162162162162 26.1 26 1 embryonic lethality between implantation and somite formation, complete penetrance 2.45292494731573e-25 1.22033016128958e-22 1.30351051868588 0.661224489795918 26.1 26 1 decreased IgM level 7.7764627858438e-11 5.68939740581955e-09 1.30069014464774 0.65979381443299 26.1 26 1 abnormal cell nucleus morphology 6.03708234536797e-06 0.000154816931279411 1.3002577343603 0.659574468085106 26.1 26 1 decreased cell proliferation 2.65438192162302e-19 6.60277503003725e-17 1.3000310111285 0.659459459459459 26.1 26 1 arrested B cell differentiation 2.51255346817392e-05 0.000520831396006886 1.29821169543919 0.658536585365854 26.1 26 1 decreased neuron apoptosis 5.14248626013167e-05 0.00098554501708217 1.29694638189588 0.657894736842105 26.1 26 1 decreased total retina thickness 5.14248626013167e-05 0.00098554501708217 1.29694638189588 0.657894736842105 26.1 26 1 decreased IgG level 4.71298873141101e-12 4.42398470542826e-10 1.29647901383033 0.657657657657658 26.1 26 1 holoprosencephaly 0.00010553084798015 0.00182932393275695 1.29546415745943 0.657142857142857 26.1 26 1 scoliosis 0.000217238850887861 0.00343099454973685 1.29370401594114 0.65625 26.1 26 1 abnormal microglial cell morphology 0.000448856049666675 0.00630807583924211 1.29157970721217 0.655172413793103 26.1 26 1 distended pericardium 2.89633281371809e-06 7.83111725448234e-05 1.28896517339191 0.653846153846154 26.1 26 1 abnormal Mullerian duct morphology 0.000931595583354043 0.0116742771465651 1.28896517339191 0.653846153846154 26.1 26 1 decreased bone resorption 0.000931595583354043 0.0116742771465651 1.28896517339191 0.653846153846154 26.1 26 1 abnormal regulatory T cell physiology 0.00194425634325898 0.0207568139650503 1.2856685872707 0.652173913043478 26.1 26 1 abnormal vertebral artery topology 0.00194425634325898 0.0207568139650503 1.2856685872707 0.652173913043478 26.1 26 1 abnormal vascular development 1.67882076812661e-07 6.52510415736709e-06 1.28436993213204 0.651515151515151 26.1 26 1 abnormal vascular regression 0.00408616519488658 0.038164838491815 1.28138302531313 0.65 26.1 26 1 abnormal physiological neovascularization 0.00408616519488658 0.038164838491815 1.28138302531313 0.65 26.1 26 1 abnormal neuron proliferation 0.00408616519488658 0.038164838491815 1.28138302531313 0.65 26.1 26 1 decreased erythrocyte cell number 1.01675546607293e-15 1.74426153231477e-13 1.28075520413463 0.64968152866242 26.1 26 1 increased hepatocellular carcinoma incidence 1.38600392860369e-06 4.17901184533536e-05 1.2796537634706 0.649122807017544 26.1 26 1 decreased embryo size 1.30107796411115e-44 1.61821571786324e-41 1.27849609863878 0.648535564853556 26.1 26 1 abnormal apoptosis 2.8065393818341e-06 7.67172166188167e-05 1.27773236142335 0.648148148148148 26.1 26 1 lethality throughout fetal growth and development, incomplete penetrance 1.51032760701658e-17 3.26690428039457e-15 1.27752841372001 0.64804469273743 26.1 26 1 increased T cell number 2.37962683234318e-09 1.37658645243108e-07 1.27690266508476 0.647727272727273 26.1 26 1 abnormal trophoblast layer morphology 5.68940289396471e-06 0.000147420726028513 1.27558491207642 0.647058823529412 26.1 26 1 enlarged liver sinusoidal spaces 0.000209023355076096 0.00334674925669803 1.27558491207642 0.647058823529412 26.1 26 1 increased brain size 0.00866612220724354 0.0692037848812787 1.27558491207642 0.647058823529412 26.1 26 1 enhanced behavioral response to cocaine 0.00866612220724354 0.0692037848812787 1.27558491207642 0.647058823529412 26.1 26 1 increased hepatoma incidence 0.00866612220724354 0.0692037848812787 1.27558491207642 0.647058823529412 26.1 26 1 osteopetrosis 0.000430157380281119 0.00613189961862053 1.27184419385919 0.645161290322581 26.1 26 1 decreased thymus weight 0.000430157380281119 0.00613189961862053 1.27184419385919 0.645161290322581 26.1 26 1 abnormal mitochondrial ATP synthesis coupled electron transport 0.000430157380281119 0.00613189961862053 1.27184419385919 0.645161290322581 26.1 26 1 trabecula carnea hypoplasia 2.34730214324279e-05 0.000496928857984378 1.27043103364379 0.644444444444444 26.1 26 1 abnormal spleen morphology 1.13250670420489e-16 2.16700802054589e-14 1.26892041410319 0.64367816091954 26.1 26 1 abnormal vitelline vasculature morphology 1.66321186036968e-11 1.37195952335711e-09 1.26852633944042 0.643478260869565 26.1 26 1 lymphoid hyperplasia 0.000888475155463818 0.0112472363827799 1.26730189316683 0.642857142857143 26.1 26 1 small superior cervical ganglion 0.000888475155463818 0.0112472363827799 1.26730189316683 0.642857142857143 26.1 26 1 abnormal spleen germinal center morphology 0.000888475155463818 0.0112472363827799 1.26730189316683 0.642857142857143 26.1 26 1 abnormal brainstem morphology 0.000888475155463818 0.0112472363827799 1.26730189316683 0.642857142857143 26.1 26 1 translucent skin 0.0186065330932695 0.12006220023727 1.26730189316683 0.642857142857143 26.1 26 1 abnormal ventral body wall morphology 0.0186065330932695 0.12006220023727 1.26730189316683 0.642857142857143 26.1 26 1 split sternum 0.0186065330932695 0.12006220023727 1.26730189316683 0.642857142857143 26.1 26 1 increased B-1 B cell number 0.0186065330932695 0.12006220023727 1.26730189316683 0.642857142857143 26.1 26 1 increased stomach tumor incidence 0.0186065330932695 0.12006220023727 1.26730189316683 0.642857142857143 26.1 26 1 extramedullary hematopoiesis 1.33100104998673e-10 9.32638059673797e-09 1.26464507578074 0.641509433962264 26.1 26 1 increased neutrophil cell number 5.8934149022495e-14 7.51788183043366e-12 1.26438855548139 0.641379310344828 26.1 26 1 decreased rib number 4.44763572651303e-09 2.45855419326693e-07 1.26255544412875 0.640449438202247 26.1 26 1 embryonic lethality before implantation, complete penetrance 3.87067948873638e-12 3.77580989342421e-10 1.26166944030831 0.64 26.1 26 1 hydrops fetalis 1.50652820049737e-07 6.04195476573176e-06 1.25947904197444 0.638888888888889 26.1 26 1 neuron degeneration 2.24326264755525e-05 0.00048312691218993 1.25831393647771 0.638297872340426 26.1 26 1 increased lymphocyte cell number 3.0274822788132e-07 1.03162495459559e-05 1.25709817422024 0.63768115942029 26.1 26 1 abnormal occipital bone morphology 0.00384465148496342 0.0363633861933327 1.25450086394292 0.636363636363636 26.1 26 1 abnormal sperm midpiece morphology 0.00384465148496342 0.0363633861933327 1.25450086394292 0.636363636363636 26.1 26 1 abnormal large intestine morphology 0.0406538578203131 0.20680259985282 1.25450086394292 0.636363636363636 26.1 26 1 impaired myelopoiesis 0.0406538578203131 0.20680259985282 1.25450086394292 0.636363636363636 26.1 26 1 abnormal proximal-distal axis patterning 0.0406538578203131 0.20680259985282 1.25450086394292 0.636363636363636 26.1 26 1 vasculitis 0.0406538578203131 0.20680259985282 1.25450086394292 0.636363636363636 26.1 26 1 abnormal spinal cord ventral horn morphology 0.0406538578203131 0.20680259985282 1.25450086394292 0.636363636363636 26.1 26 1 abnormal dorsal-ventral polarity of the somites 0.0406538578203131 0.20680259985282 1.25450086394292 0.636363636363636 26.1 26 1 increased number of Howell-Jolly bodies 0.0406538578203131 0.20680259985282 1.25450086394292 0.636363636363636 26.1 26 1 aorta dilation 0.0406538578203131 0.20680259985282 1.25450086394292 0.636363636363636 26.1 26 1 abnormal extraembryonic ectoderm morphology 0.0406538578203131 0.20680259985282 1.25450086394292 0.636363636363636 26.1 26 1 abnormal pulmonary alveolar sac morphology 0.0406538578203131 0.20680259985282 1.25450086394292 0.636363636363636 26.1 26 1 increased subcutaneous adipose tissue amount 0.0406538578203131 0.20680259985282 1.25450086394292 0.636363636363636 26.1 26 1 hypolactation 0.0406538578203131 0.20680259985282 1.25450086394292 0.636363636363636 26.1 26 1 thin hypoglossal nerve 0.0406538578203131 0.20680259985282 1.25450086394292 0.636363636363636 26.1 26 1 increased cardiomyocyte apoptosis 0.000408169452366673 0.00588592181311362 1.25450086394292 0.636363636363636 26.1 26 1 gliosis 1.22406649597829e-06 3.71325049847074e-05 1.25165619078206 0.634920634920635 26.1 26 1 decreased IgA level 1.05405246122877e-05 0.000245042569841735 1.25105443299803 0.634615384615385 26.1 26 1 kinked neural tube 1.05405246122877e-05 0.000245042569841735 1.25105443299803 0.634615384615385 26.1 26 1 thrombocytopenia 2.07412136216752e-13 2.29305639484076e-11 1.250792979616 0.63448275862069 26.1 26 1 gastrointestinal hemorrhage 0.000838630158002489 0.0108650651980791 1.2485270503051 0.633333333333333 26.1 26 1 embryonic growth arrest 3.72678241071337e-20 1.03004124962772e-17 1.24824009855831 0.633187772925764 26.1 26 1 abnormal sternebra morphology 0.00807395253085613 0.0657412665155634 1.24506852662004 0.631578947368421 26.1 26 1 abnormal blastocyst morphology 0.00807395253085613 0.0657412665155634 1.24506852662004 0.631578947368421 26.1 26 1 abnormal allantois morphology 4.3100282658312e-05 0.000847525321047835 1.24281296769501 0.630434782608696 26.1 26 1 abnormal cytokine secretion 9.05685460428956e-14 1.09897199161806e-11 1.24169983471902 0.62987012987013 26.1 26 1 abnormal cell adhesion 9.98562532040191e-06 0.000236564218899998 1.24122572252554 0.62962962962963 26.1 26 1 abnormal atrioventricular cushion morphology 0.00172877567483035 0.0187787314023603 1.24122572252554 0.62962962962963 26.1 26 1 pallor 2.52731062757356e-15 4.19112345739282e-13 1.23913962887424 0.628571428571429 26.1 26 1 abnormal liver development 0.000384164520930775 0.00558835816266259 1.23913962887424 0.628571428571429 26.1 26 1 increased spleen weight 2.11871473373341e-10 1.42440618923294e-08 1.23864118171861 0.628318584070796 26.1 26 1 abnormal gastrulation 2.01226085123007e-05 0.00044101311607355 1.23693082383168 0.627450980392157 26.1 26 1 embryonic lethality during organogenesis, complete penetrance 2.23612825770809e-45 5.56236904104887e-42 1.23561934583766 0.626785714285714 26.1 26 1 increased grip strength 1.46664848875172e-08 7.08405459372797e-07 1.23480697282922 0.626373626373626 26.1 26 1 lethality throughout fetal growth and development, complete penetrance 2.77413189661064e-16 5.11159488356961e-14 1.23469295556488 0.626315789473684 26.1 26 1 vertebral transformation 4.05735375896738e-05 0.000804196611588156 1.23209906280109 0.625 26.1 26 1 abnormal bone marrow cell number 0.017104739269354 0.114376448743328 1.23209906280109 0.625 26.1 26 1 disorganized yolk sac vascular plexus 0.017104739269354 0.114376448743328 1.23209906280109 0.625 26.1 26 1 large intestinal inflammation 0.017104739269354 0.114376448743328 1.23209906280109 0.625 26.1 26 1 kidney degeneration 0.017104739269354 0.114376448743328 1.23209906280109 0.625 26.1 26 1 impaired somite development 0.017104739269354 0.114376448743328 1.23209906280109 0.625 26.1 26 1 increased heart left ventricle size 0.017104739269354 0.114376448743328 1.23209906280109 0.625 26.1 26 1 decreased midbrain size 0.017104739269354 0.114376448743328 1.23209906280109 0.625 26.1 26 1 absent pre-B cells 0.0912491457941041 0.359718304536979 1.23209906280109 0.625 26.1 26 1 enlarged pituitary gland 0.0912491457941041 0.359718304536979 1.23209906280109 0.625 26.1 26 1 abnormal vagus ganglion morphology 0.0912491457941041 0.359718304536979 1.23209906280109 0.625 26.1 26 1 increased sensitivity to skin irradiation 0.0912491457941041 0.359718304536979 1.23209906280109 0.625 26.1 26 1 preneoplasia 0.0912491457941041 0.359718304536979 1.23209906280109 0.625 26.1 26 1 abnormal hepatobiliary system morphology 0.0912491457941041 0.359718304536979 1.23209906280109 0.625 26.1 26 1 joint swelling 0.0912491457941041 0.359718304536979 1.23209906280109 0.625 26.1 26 1 binucleate 0.0912491457941041 0.359718304536979 1.23209906280109 0.625 26.1 26 1 abnormal choroid pigmentation 0.0912491457941041 0.359718304536979 1.23209906280109 0.625 26.1 26 1 abnormal somite size 0.0912491457941041 0.359718304536979 1.23209906280109 0.625 26.1 26 1 abnormal vertebral body development 0.0912491457941041 0.359718304536979 1.23209906280109 0.625 26.1 26 1 Sertoli cell hypoplasia 0.0912491457941041 0.359718304536979 1.23209906280109 0.625 26.1 26 1 craniofacial phenotype 0.0912491457941041 0.359718304536979 1.23209906280109 0.625 26.1 26 1 abnormal epidermal lamellar body morphology 0.0912491457941041 0.359718304536979 1.23209906280109 0.625 26.1 26 1 abnormal sphingomyelin level 0.0912491457941041 0.359718304536979 1.23209906280109 0.625 26.1 26 1 decreased hippocampus pyramidal cell number 0.0912491457941041 0.359718304536979 1.23209906280109 0.625 26.1 26 1 decreased quadriceps weight 0.0912491457941041 0.359718304536979 1.23209906280109 0.625 26.1 26 1 ostium secundum atrial septal defect 0.0912491457941041 0.359718304536979 1.23209906280109 0.625 26.1 26 1 myocardial trabeculae hypoplasia 0.0912491457941041 0.359718304536979 1.23209906280109 0.625 26.1 26 1 delayed suture closure 0.0912491457941041 0.359718304536979 1.23209906280109 0.625 26.1 26 1 abnormal foramen magnum morphology 0.0912491457941041 0.359718304536979 1.23209906280109 0.625 26.1 26 1 increased cardiac stroke volume 0.0912491457941041 0.359718304536979 1.23209906280109 0.625 26.1 26 1 increased cornea thickness 0.0912491457941041 0.359718304536979 1.23209906280109 0.625 26.1 26 1 absent hypoglossal canal 0.0912491457941041 0.359718304536979 1.23209906280109 0.625 26.1 26 1 increased mammary gland apoptosis 0.0912491457941041 0.359718304536979 1.23209906280109 0.625 26.1 26 1 decreased basal metabolism 0.0912491457941041 0.359718304536979 1.23209906280109 0.625 26.1 26 1 decreased vascular endothelial cell proliferation 0.0912491457941041 0.359718304536979 1.23209906280109 0.625 26.1 26 1 increased B cell number 1.89970587747481e-10 1.29466256718317e-08 1.22999291055698 0.623931623931624 26.1 26 1 embryonic lethality, complete penetrance 6.48864814339034e-26 3.58678050148522e-23 1.22978163509676 0.623824451410658 26.1 26 1 abnormal mesoderm development 1.8914381057856e-05 0.000416367459127582 1.22744963237542 0.622641509433962 26.1 26 1 abnormal hepatocyte morphology 7.47288923587715e-10 4.58983011709738e-08 1.22543906786703 0.621621621621622 26.1 26 1 increased leukocyte cell number 2.35370873447152e-12 2.38973488857057e-10 1.22360182788522 0.620689655172414 26.1 26 1 decreased granulocyte number 0.00160785187404095 0.0175745423432606 1.22360182788522 0.620689655172414 26.1 26 1 abnormal outer ear morphology 0.00160785187404095 0.0175745423432606 1.22360182788522 0.620689655172414 26.1 26 1 abnormal embryonic erythropoiesis 0.00160785187404095 0.0175745423432606 1.22360182788522 0.620689655172414 26.1 26 1 blood in lymph vessels 0.00160785187404095 0.0175745423432606 1.22360182788522 0.620689655172414 26.1 26 1 abnormal placenta morphology 2.30525800342059e-07 8.31062215001262e-06 1.22274134840007 0.620253164556962 26.1 26 1 abnormal embryo size 7.03457048280861e-10 4.37462351899661e-08 1.22119553127187 0.619469026548673 26.1 26 1 abnormal hematopoietic system physiology 0.00743980448278276 0.0611785575237094 1.2203647860125 0.619047619047619 26.1 26 1 left pulmonary isomerism 0.00743980448278276 0.0611785575237094 1.2203647860125 0.619047619047619 26.1 26 1 embryonic lethality at implantation, complete penetrance 0.00743980448278276 0.0611785575237094 1.2203647860125 0.619047619047619 26.1 26 1 abnormal embryo development 1.81646595951968e-11 1.45756744332426e-09 1.21760377970931 0.617647058823529 26.1 26 1 pericardial edema 1.94167837898739e-06 5.51991424883559e-05 1.21760377970931 0.617647058823529 26.1 26 1 decreased hemoglobin content 8.64073466206862e-12 7.54169384978796e-10 1.21637013859511 0.617021276595745 26.1 26 1 muscular ventricular septal defect 8.26624997060412e-06 0.000197714392325747 1.21567107529707 0.616666666666667 26.1 26 1 abnormal fertility/fecundity 9.12316804941155e-07 2.81911559290823e-05 1.21522099344765 0.616438356164384 26.1 26 1 abnormal leukocyte migration 3.54539427523216e-05 0.00070836692848514 1.21314369260415 0.615384615384615 26.1 26 1 increased hepatocyte apoptosis 0.00033383091479536 0.00494288333662773 1.21314369260415 0.615384615384615 26.1 26 1 increased susceptibility to otitis media 0.00330180966465076 0.0321725678673037 1.21314369260415 0.615384615384615 26.1 26 1 decreased circulating glycerol level 0.00330180966465076 0.0321725678673037 1.21314369260415 0.615384615384615 26.1 26 1 abnormal mast cell morphology 0.0366621277383597 0.198748486740044 1.21314369260415 0.615384615384615 26.1 26 1 increased foot pad pigmentation 0.0366621277383597 0.198748486740044 1.21314369260415 0.615384615384615 26.1 26 1 increased pituitary adenoma incidence 0.0366621277383597 0.198748486740044 1.21314369260415 0.615384615384615 26.1 26 1 axonal dystrophy 0.0366621277383597 0.198748486740044 1.21314369260415 0.615384615384615 26.1 26 1 abnormal exocrine pancreas morphology 0.0366621277383597 0.198748486740044 1.21314369260415 0.615384615384615 26.1 26 1 orthokeratosis 0.0366621277383597 0.198748486740044 1.21314369260415 0.615384615384615 26.1 26 1 empty decidua capsularis 0.0366621277383597 0.198748486740044 1.21314369260415 0.615384615384615 26.1 26 1 abnormal aorta tunica media morphology 0.0366621277383597 0.198748486740044 1.21314369260415 0.615384615384615 26.1 26 1 absent hypoglossal nerve 0.0366621277383597 0.198748486740044 1.21314369260415 0.615384615384615 26.1 26 1 decreased birth body size 1.22306234404969e-09 7.33100621885207e-08 1.21048328976949 0.614035087719298 26.1 26 1 impaired natural killer cell mediated cytotoxicity 1.6505183658405e-05 0.000369549331465709 1.21048328976949 0.614035087719298 26.1 26 1 increased macrophage cell number 1.6505183658405e-05 0.000369549331465709 1.21048328976949 0.614035087719298 26.1 26 1 abnormal myelopoiesis 0.000153590975390478 0.00257277812312333 1.20969726165925 0.613636363636364 26.1 26 1 decreased leukocyte cell number 3.14678913381449e-11 2.44613686573861e-09 1.20871616087931 0.613138686131387 26.1 26 1 oxidative stress 8.89444075503816e-08 3.71847418120293e-06 1.20471908362773 0.611111111111111 26.1 26 1 abnormal small intestine morphology 3.2945282930998e-05 0.000660898316861754 1.20471908362773 0.611111111111111 26.1 26 1 abnormal trophoblast giant cell morphology 0.000674791670207472 0.00904875622448025 1.20471908362773 0.611111111111111 26.1 26 1 abnormal megakaryocyte differentiation 0.015560645386475 0.106631144349467 1.20471908362773 0.611111111111111 26.1 26 1 abnormal mitral valve morphology 0.015560645386475 0.106631144349467 1.20471908362773 0.611111111111111 26.1 26 1 absent inner cell mass 0.015560645386475 0.106631144349467 1.20471908362773 0.611111111111111 26.1 26 1 decreased lactate dehydrogenase level 0.015560645386475 0.106631144349467 1.20471908362773 0.611111111111111 26.1 26 1 increased gastrointestinal tumor incidence 0.015560645386475 0.106631144349467 1.20471908362773 0.611111111111111 26.1 26 1 decreased tumor latency 0.015560645386475 0.106631144349467 1.20471908362773 0.611111111111111 26.1 26 1 abnormal aerobic respiration 0.015560645386475 0.106631144349467 1.20471908362773 0.611111111111111 26.1 26 1 abnormal osteoclast physiology 7.15824247960067e-06 0.000176298298693135 1.20129658623106 0.609375 26.1 26 1 perimembraneous ventricular septal defect 3.34871541646827e-06 9.00532929563764e-05 1.19995734811932 0.608695652173913 26.1 26 1 abnormal Wolffian duct morphology 0.00680082170539256 0.058334634455738 1.19995734811932 0.608695652173913 26.1 26 1 abnormal hematopoietic stem cell physiology 0.00680082170539256 0.058334634455738 1.19995734811932 0.608695652173913 26.1 26 1 increased granulocyte number 1.5696220112793e-06 4.54598010491125e-05 1.19879908813079 0.608108108108108 26.1 26 1 abnormal extraembryonic tissue morphology 1.8445019218999e-08 8.57607202004862e-07 1.19827673558694 0.607843137254902 26.1 26 1 abnormal placenta labyrinth morphology 7.36957177322791e-07 2.33526239310884e-05 1.19778744333068 0.607594936708861 26.1 26 1 straub tail 0.00302742193203318 0.029824602201713 1.19689623243534 0.607142857142857 26.1 26 1 abnormal mitotic spindle morphology 0.00302742193203318 0.029824602201713 1.19689623243534 0.607142857142857 26.1 26 1 abnormal NK cell physiology 1.42064795185533e-05 0.00032570154656591 1.19574204127581 0.60655737704918 26.1 26 1 abnormal QRS complex 0.00136479412450559 0.0153964870054769 1.19476272756469 0.606060606060606 26.1 26 1 decreased hair follicle number 0.000620956998624423 0.0084163540357759 1.19319067134421 0.605263157894737 26.1 26 1 abnormal vasculogenesis 0.000284511753854333 0.00427627182907947 1.19198420959361 0.604651162790698 26.1 26 1 abnormal double-strand DNA break repair 0.000284511753854333 0.00427627182907947 1.19198420959361 0.604651162790698 26.1 26 1 small heart 0.000131077880120975 0.00221055069017577 1.19102909404105 0.604166666666667 26.1 26 1 abnormal spermiogenesis 2.8171517962454e-05 0.00057205429331922 1.18961288822174 0.603448275862069 26.1 26 1 abnormal embryonic neuroepithelium morphology 2.8171517962454e-05 0.00057205429331922 1.18961288822174 0.603448275862069 26.1 26 1 decreased circulating alanine transaminase level 6.12914725565342e-06 0.000156036985959711 1.18861321352575 0.602941176470588 26.1 26 1 seminiferous tubule degeneration 2.86874330100663e-06 7.79890596858359e-05 1.18821608248214 0.602739726027397 26.1 26 1 decreased circulating calcium level 5.58093600360403e-05 0.00103601330663918 1.18281510028904 0.6 26.1 26 1 abnormal embryo turning 5.58093600360403e-05 0.00103601330663918 1.18281510028904 0.6 26.1 26 1 abnormal platelet physiology 5.58093600360403e-05 0.00103601330663918 1.18281510028904 0.6 26.1 26 1 abnormal myocardial trabeculae morphology 0.00026118971907603 0.00399821185354846 1.18281510028904 0.6 26.1 26 1 abnormal cell proliferation 0.0140556335348105 0.097799687882073 1.18281510028904 0.6 26.1 26 1 increased mammary adenocarcinoma incidence 0.0140556335348105 0.097799687882073 1.18281510028904 0.6 26.1 26 1 abnormal induced retinal neovascularization 0.0140556335348105 0.097799687882073 1.18281510028904 0.6 26.1 26 1 retarded hair growth 0.0798715726374718 0.32921381430938 1.18281510028904 0.6 26.1 26 1 increased cranium width 0.0798715726374718 0.32921381430938 1.18281510028904 0.6 26.1 26 1 kidney hemorrhage 0.0798715726374718 0.32921381430938 1.18281510028904 0.6 26.1 26 1 absent trophoblast giant cells 0.0798715726374718 0.32921381430938 1.18281510028904 0.6 26.1 26 1 abnormal immune cell physiology 0.0798715726374718 0.32921381430938 1.18281510028904 0.6 26.1 26 1 rhinitis 0.0798715726374718 0.32921381430938 1.18281510028904 0.6 26.1 26 1 abnormal neuron specification 0.0798715726374718 0.32921381430938 1.18281510028904 0.6 26.1 26 1 abnormal tibialis anterior morphology 0.0798715726374718 0.32921381430938 1.18281510028904 0.6 26.1 26 1 acrania 0.0798715726374718 0.32921381430938 1.18281510028904 0.6 26.1 26 1 abnormal submandibular gland morphology 0.0798715726374718 0.32921381430938 1.18281510028904 0.6 26.1 26 1 increased heart rate variability 0.0798715726374718 0.32921381430938 1.18281510028904 0.6 26.1 26 1 abnormal embryonic erythrocyte morphology 0.0798715726374718 0.32921381430938 1.18281510028904 0.6 26.1 26 1 abnormal respiratory conducting tube morphology 0.0798715726374718 0.32921381430938 1.18281510028904 0.6 26.1 26 1 decreased cochlear inner hair cell number 0.0798715726374718 0.32921381430938 1.18281510028904 0.6 26.1 26 1 abnormal corneal endothelium morphology 0.0798715726374718 0.32921381430938 1.18281510028904 0.6 26.1 26 1 ascites 0.0798715726374718 0.32921381430938 1.18281510028904 0.6 26.1 26 1 vascular smooth muscle hyperplasia 0.0798715726374718 0.32921381430938 1.18281510028904 0.6 26.1 26 1 increased platelet aggregation 0.0798715726374718 0.32921381430938 1.18281510028904 0.6 26.1 26 1 protruding tongue 0.0798715726374718 0.32921381430938 1.18281510028904 0.6 26.1 26 1 abnormal hippocampus neuron morphology 0.0798715726374718 0.32921381430938 1.18281510028904 0.6 26.1 26 1 increased T-helper 17 cell number 0.0798715726374718 0.32921381430938 1.18281510028904 0.6 26.1 26 1 abnormal vibrissa follicle morphology 0.0798715726374718 0.32921381430938 1.18281510028904 0.6 26.1 26 1 decreased birth weight 1.29275433074848e-07 5.27168261924073e-06 1.18281510028904 0.6 26.1 26 1 increased circulating serum albumin level 0.00124842070396323 0.0144104245991115 1.18281510028904 0.6 26.1 26 1 abnormal embryonic epiblast morphology 0.00124842070396323 0.0144104245991115 1.18281510028904 0.6 26.1 26 1 decreased circulating thyroxine level 0.00124842070396323 0.0144104245991115 1.18281510028904 0.6 26.1 26 1 increased metastatic potential 0.00276168444809866 0.0275338279144105 1.18281510028904 0.6 26.1 26 1 abnormal brain vasculature morphology 0.00276168444809866 0.0275338279144105 1.18281510028904 0.6 26.1 26 1 ruffled hair 0.00617972345504823 0.053748468861652 1.18281510028904 0.6 26.1 26 1 abnormal thyroid gland morphology 0.00617972345504823 0.053748468861652 1.18281510028904 0.6 26.1 26 1 abnormal primitive streak morphology 0.00617972345504823 0.053748468861652 1.18281510028904 0.6 26.1 26 1 abnormal egg cylinder morphology 0.00617972345504823 0.053748468861652 1.18281510028904 0.6 26.1 26 1 abnormal fontanelle morphology 0.0327810534426339 0.184486132213918 1.18281510028904 0.6 26.1 26 1 audiogenic seizures 0.0327810534426339 0.184486132213918 1.18281510028904 0.6 26.1 26 1 arthritis 0.0327810534426339 0.184486132213918 1.18281510028904 0.6 26.1 26 1 abnormal glial cell morphology 0.0327810534426339 0.184486132213918 1.18281510028904 0.6 26.1 26 1 abnormal pericyte morphology 0.0327810534426339 0.184486132213918 1.18281510028904 0.6 26.1 26 1 abnormal placenta size 0.0327810534426339 0.184486132213918 1.18281510028904 0.6 26.1 26 1 abnormal trophectoderm morphology 0.0327810534426339 0.184486132213918 1.18281510028904 0.6 26.1 26 1 bicuspid aortic valve 0.0327810534426339 0.184486132213918 1.18281510028904 0.6 26.1 26 1 abnormal developmental patterning 1.14347457029152e-06 3.49005275288364e-05 1.17800690882445 0.597560975609756 26.1 26 1 increased eosinophil cell number 2.38297320791878e-05 0.000502342869042199 1.17645587931975 0.596774193548387 26.1 26 1 absent vitelline blood vessels 5.12151673072872e-05 0.00098554501708217 1.17589805291893 0.596491228070175 26.1 26 1 decreased brain weight 5.12151673072872e-05 0.00098554501708217 1.17589805291893 0.596491228070175 26.1 26 1 increased erythroid progenitor cell number 0.00113775742577976 0.013318454572363 1.17215910839455 0.594594594594595 26.1 26 1 microcephaly 1.02004938773173e-05 0.000239374797356857 1.17138693506886 0.594202898550725 26.1 26 1 decreased spleen weight 1.02004938773173e-05 0.000239374797356857 1.17138693506886 0.594202898550725 26.1 26 1 decreased caudal vertebrae number 2.18421029339409e-05 0.000472454183027635 1.17049410966103 0.59375 26.1 26 1 failure of primitive streak formation 0.00250897760034625 0.0256307259994303 1.17049410966103 0.59375 26.1 26 1 increased neuron apoptosis 2.0535674879658e-06 5.80482855263061e-05 1.16821244472992 0.592592592592593 26.1 26 1 anemia 2.21063059480151e-14 2.97240194841554e-12 1.167866410238 0.592417061611374 26.1 26 1 decreased circulating creatinine level 0.000218193519497633 0.00343516696044533 1.16672237783613 0.591836734693878 26.1 26 1 lethality, incomplete penetrance 0.000473619544968785 0.00654515898949919 1.16489365937557 0.590909090909091 26.1 26 1 abnormal tail movements 0.0126328032574107 0.0903684275895394 1.16489365937557 0.590909090909091 26.1 26 1 increased activated T cell number 0.0126328032574107 0.0903684275895394 1.16489365937557 0.590909090909091 26.1 26 1 intestinal inflammation 0.0126328032574107 0.0903684275895394 1.16489365937557 0.590909090909091 26.1 26 1 abnormal cerebral cortex pyramidal cell morphology 0.0126328032574107 0.0903684275895394 1.16489365937557 0.590909090909091 26.1 26 1 increased circulating creatine kinase level 0.0126328032574107 0.0903684275895394 1.16489365937557 0.590909090909091 26.1 26 1 embryonic lethality before implantation, incomplete penetrance 0.0126328032574107 0.0903684275895394 1.16489365937557 0.590909090909091 26.1 26 1 abnormal humoral immune response 8.50144031131484e-08 3.58429369057554e-06 1.16404025742731 0.59047619047619 26.1 26 1 failure of heart looping 0.00103370074412871 0.0122785995322745 1.16259603874564 0.58974358974359 26.1 26 1 increased lung adenocarcinoma incidence 0.000198694701602921 0.0032094355210212 1.1596226473422 0.588235294117647 26.1 26 1 decreased mean corpuscular hemoglobin 1.8244776263569e-05 0.000403412275161138 1.1596226473422 0.588235294117647 26.1 26 1 abnormal direction of heart looping 0.00227183288216534 0.02344889748708 1.1596226473422 0.588235294117647 26.1 26 1 abnormal cranial suture morphology 0.0291599065009404 0.16849074894562 1.1596226473422 0.588235294117647 26.1 26 1 abnormal glutamate-mediated receptor currents 0.0291599065009404 0.16849074894562 1.1596226473422 0.588235294117647 26.1 26 1 increased regulatory T cell number 0.0291599065009404 0.16849074894562 1.1596226473422 0.588235294117647 26.1 26 1 abnormal circulating chemokine level 0.0291599065009404 0.16849074894562 1.1596226473422 0.588235294117647 26.1 26 1 delayed heart development 0.0291599065009404 0.16849074894562 1.1596226473422 0.588235294117647 26.1 26 1 abnormal ductus venosus valve morphology 0.0291599065009404 0.16849074894562 1.1596226473422 0.588235294117647 26.1 26 1 increased bone mineral content 7.12551660554782e-08 3.08256044457395e-06 1.15749489936542 0.587155963302752 26.1 26 1 delayed bone ossification 7.79428723476865e-06 0.000188235820354243 1.15653032028262 0.586666666666667 26.1 26 1 hemopericardium 0.00093671117232317 0.0116949663101651 1.1539659515015 0.585365853658537 26.1 26 1 abnormal embryonic tissue morphology 5.66272957726096e-10 3.56608603124978e-08 1.15331177579204 0.585034013605442 26.1 26 1 anophthalmia 1.43301700659843e-06 4.29473470351036e-05 1.1518049665736 0.584269662921348 26.1 26 1 abnormal pharyngeal arch morphology 0.0020515013512213 0.0215806313289563 1.14995912528101 0.583333333333333 26.1 26 1 ocular hypertelorism 0.0113130251956788 0.0846350381180484 1.14995912528101 0.583333333333333 26.1 26 1 hemolytic anemia 0.0113130251956788 0.0846350381180484 1.14995912528101 0.583333333333333 26.1 26 1 abnormal primitive streak formation 0.0113130251956788 0.0846350381180484 1.14995912528101 0.583333333333333 26.1 26 1 increased body temperature 0.0113130251956788 0.0846350381180484 1.14995912528101 0.583333333333333 26.1 26 1 myocarditis 0.06968488887958 0.299380243675225 1.14995912528101 0.583333333333333 26.1 26 1 abnormal embryonic growth/weight/body size 0.06968488887958 0.299380243675225 1.14995912528101 0.583333333333333 26.1 26 1 abnormal respiratory function 0.06968488887958 0.299380243675225 1.14995912528101 0.583333333333333 26.1 26 1 decreased synaptic depression 0.06968488887958 0.299380243675225 1.14995912528101 0.583333333333333 26.1 26 1 abnormal gastrocnemius morphology 0.06968488887958 0.299380243675225 1.14995912528101 0.583333333333333 26.1 26 1 abnormal defecation 0.06968488887958 0.299380243675225 1.14995912528101 0.583333333333333 26.1 26 1 abnormal rostral-caudal body axis extension 0.06968488887958 0.299380243675225 1.14995912528101 0.583333333333333 26.1 26 1 pale placenta 0.06968488887958 0.299380243675225 1.14995912528101 0.583333333333333 26.1 26 1 stria vascularis degeneration 0.06968488887958 0.299380243675225 1.14995912528101 0.583333333333333 26.1 26 1 abnormal B cell proliferation 0.06968488887958 0.299380243675225 1.14995912528101 0.583333333333333 26.1 26 1 abnormal thymus corticomedullary boundary morphology 0.06968488887958 0.299380243675225 1.14995912528101 0.583333333333333 26.1 26 1 decreased keratinocyte proliferation 0.06968488887958 0.299380243675225 1.14995912528101 0.583333333333333 26.1 26 1 decreased oligodendrocyte number 0.06968488887958 0.299380243675225 1.14995912528101 0.583333333333333 26.1 26 1 decreased mammary gland epithelial cell proliferation 0.06968488887958 0.299380243675225 1.14995912528101 0.583333333333333 26.1 26 1 increased skeletal muscle glycogen level 0.06968488887958 0.299380243675225 1.14995912528101 0.583333333333333 26.1 26 1 hydroencephaly 5.4249747871574e-08 2.36747803211474e-06 1.14853060462849 0.582608695652174 26.1 26 1 abnormal somite development 6.46583823810384e-06 0.000162462349669528 1.1478796331919 0.582278481012658 26.1 26 1 abnormal response to infection 6.46583823810384e-06 0.000162462349669528 1.1478796331919 0.582278481012658 26.1 26 1 decreased circulating total protein level 0.00016379061895368 0.00269775917026283 1.1469722184621 0.581818181818182 26.1 26 1 pale kidney 0.00452887699091957 0.0403784283688618 1.14465977447327 0.580645161290323 26.1 26 1 preaxial polydactyly 0.00452887699091957 0.0403784283688618 1.14465977447327 0.580645161290323 26.1 26 1 abnormal coat/hair pigmentation 1.04275254356333e-07 4.28735033407238e-06 1.14409198688672 0.580357142857143 26.1 26 1 cleft palate 9.24765229465589e-09 4.74299692432093e-07 1.14368890104284 0.580152671755725 26.1 26 1 abnormal interventricular septum morphology 0.000353128679927059 0.0051976780551394 1.14338793027941 0.58 26.1 26 1 decreased circulating alkaline phosphatase level 0.000353128679927059 0.0051976780551394 1.14338793027941 0.58 26.1 26 1 persistence of hyaloid vascular system 0.00184835801311834 0.0198608663396625 1.14131281606837 0.578947368421053 26.1 26 1 incomplete somite formation 0.00184835801311834 0.0198608663396625 1.14131281606837 0.578947368421053 26.1 26 1 abnormal response to novelty 0.0258548480629509 0.151862891514971 1.14131281606837 0.578947368421053 26.1 26 1 abnormal digestive system development 0.0258548480629509 0.151862891514971 1.14131281606837 0.578947368421053 26.1 26 1 increased liver adenoma incidence 0.0258548480629509 0.151862891514971 1.14131281606837 0.578947368421053 26.1 26 1 absent amnion 0.0258548480629509 0.151862891514971 1.14131281606837 0.578947368421053 26.1 26 1 Leydig cell hypoplasia 0.0258548480629509 0.151862891514971 1.14131281606837 0.578947368421053 26.1 26 1 increased liver cholesterol level 0.0258548480629509 0.151862891514971 1.14131281606837 0.578947368421053 26.1 26 1 embryonic lethality between implantation and somite formation, incomplete penetrance 0.0258548480629509 0.151862891514971 1.14131281606837 0.578947368421053 26.1 26 1 abnormal ectoderm development 0.000764312990927288 0.0100481028915643 1.13900713361167 0.577777777777778 26.1 26 1 abnormal brain wave pattern 0.000319055248086603 0.00473820853501747 1.13732221181639 0.576923076923077 26.1 26 1 abnormal leukocyte cell number 0.0101041513510448 0.0767452717121343 1.13732221181639 0.576923076923077 26.1 26 1 heart inflammation 0.0101041513510448 0.0767452717121343 1.13732221181639 0.576923076923077 26.1 26 1 decreased circulating serum albumin level 8.90362485642027e-07 2.76847085379318e-05 1.13502459118645 0.575757575757576 26.1 26 1 decreased brown adipose tissue amount 0.00406179803184431 0.038164838491815 1.13502459118645 0.575757575757576 26.1 26 1 myeloid hyperplasia 0.00406179803184431 0.038164838491815 1.13502459118645 0.575757575757576 26.1 26 1 neurodegeneration 0.000287852417360233 0.0043004978269284 1.13170580583211 0.574074074074074 26.1 26 1 domed cranium 4.62841837971708e-05 0.000902995350552647 1.12649057170385 0.571428571428571 26.1 26 1 abnormal craniofacial development 0.000619539428668481 0.0084163540357759 1.12649057170385 0.571428571428571 26.1 26 1 abnormal cartilage morphology 0.00149239801106759 0.0164992891223583 1.12649057170385 0.571428571428571 26.1 26 1 abnormal reproductive system morphology 0.00149239801106759 0.0164992891223583 1.12649057170385 0.571428571428571 26.1 26 1 hypoxia 0.00900644200086466 0.0706735787922739 1.12649057170385 0.571428571428571 26.1 26 1 abnormal renal tubule epithelium morphology 0.00900644200086466 0.0706735787922739 1.12649057170385 0.571428571428571 26.1 26 1 abnormal eye pigmentation 0.0228767389375141 0.137620043789761 1.12649057170385 0.571428571428571 26.1 26 1 abnormal erythrocyte physiology 0.0228767389375141 0.137620043789761 1.12649057170385 0.571428571428571 26.1 26 1 abnormal kidney blood vessel morphology 0.0607362539318132 0.269067554150285 1.12649057170385 0.571428571428571 26.1 26 1 increased lactate dehydrogenase level 0.0607362539318132 0.269067554150285 1.12649057170385 0.571428571428571 26.1 26 1 failure of zygotic cell division 0.0607362539318132 0.269067554150285 1.12649057170385 0.571428571428571 26.1 26 1 absent olfactory bulb 0.0607362539318132 0.269067554150285 1.12649057170385 0.571428571428571 26.1 26 1 abnormal viscerocranium morphology 0.0607362539318132 0.269067554150285 1.12649057170385 0.571428571428571 26.1 26 1 abnormal glucose tolerance 0.0607362539318132 0.269067554150285 1.12649057170385 0.571428571428571 26.1 26 1 spina bifida occulta 0.0607362539318132 0.269067554150285 1.12649057170385 0.571428571428571 26.1 26 1 abnormal renal tubule epithelial cell primary cilium morphology 0.0607362539318132 0.269067554150285 1.12649057170385 0.571428571428571 26.1 26 1 teratozoospermia 6.84784266505348e-06 0.000169492623177319 1.1200900570919 0.568181818181818 26.1 26 1 omphalocele 0.00133814675257713 0.0151992696211671 1.1200900570919 0.568181818181818 26.1 26 1 decreased bone mineral density 7.878958891714e-15 1.22493189019616e-12 1.11907944952159 0.567669172932331 26.1 26 1 small seminiferous tubules 3.76274453750873e-05 0.000748786162964237 1.11887914892207 0.567567567567568 26.1 26 1 increased trabecular bone volume 0.00325079025336333 0.0318359872253594 1.11887914892207 0.567567567567568 26.1 26 1 abnormal respiratory electron transport chain 0.00325079025336333 0.0318359872253594 1.11887914892207 0.567567567567568 26.1 26 1 cachexia 1.1370934962943e-06 3.49005275288364e-05 1.11836684161945 0.567307692307692 26.1 26 1 liver inflammation 1.90430456273559e-07 7.07008596985787e-06 1.11710315027298 0.566666666666667 26.1 26 1 epidermal hyperplasia 0.000209886586550711 0.00334674925669803 1.11710315027298 0.566666666666667 26.1 26 1 increased erythrocyte cell number 0.000209886586550711 0.00334674925669803 1.11710315027298 0.566666666666667 26.1 26 1 salivary gland inflammation 0.00801582690830673 0.0654823298338686 1.11710315027298 0.566666666666667 26.1 26 1 atrioventricular septal defect 0.000499694326868684 0.00684842775804877 1.11586330215947 0.566037735849057 26.1 26 1 hemorrhage 4.15052413942334e-13 4.39337395609173e-11 1.1157050236769 0.565957446808511 26.1 26 1 increased mean corpuscular hemoglobin 2.38801444565432e-06 6.64638255887472e-05 1.11511187906038 0.565656565656566 26.1 26 1 abnormal sternum morphology 7.97563949094188e-05 0.00144286568972494 1.11424610896794 0.565217391304348 26.1 26 1 abnormal pulmonary artery morphology 0.0202143792750343 0.126158229015468 1.11424610896794 0.565217391304348 26.1 26 1 abnormal nasal cavity morphology 0.0202143792750343 0.126158229015468 1.11424610896794 0.565217391304348 26.1 26 1 decreased effector memory CD8-positive, alpha-beta T cell number 0.0202143792750343 0.126158229015468 1.11424610896794 0.565217391304348 26.1 26 1 pericardial effusion 0.000188540386164323 0.00305533687676712 1.11286366962679 0.564516129032258 26.1 26 1 decreased neutrophil cell number 3.59573106143994e-07 1.19971729439777e-05 1.11204838488713 0.564102564102564 26.1 26 1 abnormal leukocyte adhesion 0.00290262036122256 0.0287660085599248 1.11204838488713 0.564102564102564 26.1 26 1 abnormal rostral-caudal axis patterning 0.000448098906968694 0.00630807583924211 1.11112933663516 0.563636363636364 26.1 26 1 abnormal osteoclast morphology 0.00107230070365233 0.0126714869374592 1.10888915652098 0.5625 26.1 26 1 polydipsia 0.00712589049308529 0.0597642256992597 1.10888915652098 0.5625 26.1 26 1 decreased susceptibility to parasitic infection 0.00712589049308529 0.0597642256992597 1.10888915652098 0.5625 26.1 26 1 increased fatty acid level 0.00712589049308529 0.0597642256992597 1.10888915652098 0.5625 26.1 26 1 decreased mast cell number 0.0529363145225651 0.239634362829628 1.10888915652098 0.5625 26.1 26 1 abnormal hair follicle orientation 0.0529363145225651 0.239634362829628 1.10888915652098 0.5625 26.1 26 1 reduced male mating frequency 0.0529363145225651 0.239634362829628 1.10888915652098 0.5625 26.1 26 1 poor circulation 0.0529363145225651 0.239634362829628 1.10888915652098 0.5625 26.1 26 1 intraventricular hemorrhage 0.0529363145225651 0.239634362829628 1.10888915652098 0.5625 26.1 26 1 abnormal meiosis 0.0529363145225651 0.239634362829628 1.10888915652098 0.5625 26.1 26 1 abnormal olfaction 0.0529363145225651 0.239634362829628 1.10888915652098 0.5625 26.1 26 1 increased cochlear outer hair cell number 0.0529363145225651 0.239634362829628 1.10888915652098 0.5625 26.1 26 1 dystonia 0.0529363145225651 0.239634362829628 1.10888915652098 0.5625 26.1 26 1 embryonic lethality between somite formation and embryo turning, incomplete penetrance 0.0529363145225651 0.239634362829628 1.10888915652098 0.5625 26.1 26 1 double outlet right ventricle 1.57167553375826e-06 4.54598010491125e-05 1.10543467316733 0.560747663551402 26.1 26 1 kyphosis 1.55773321652911e-08 7.38068833545935e-07 1.10396076026977 0.56 26.1 26 1 testicular atrophy 0.000958607654339374 0.0117897078720392 1.10396076026977 0.56 26.1 26 1 mandible hypoplasia 0.0178463183201177 0.11885600219891 1.10396076026977 0.56 26.1 26 1 preweaning lethality, incomplete penetrance 1.08909708533848e-20 3.38641124972433e-18 1.10376796237242 0.559902200488998 26.1 26 1 decreased circulating glucose level 1.68718331707848e-14 2.33159361179595e-12 1.10226496801129 0.559139784946237 26.1 26 1 increased susceptibility to viral infection induced morbidity/mortality 0.00632908722143765 0.0549514989993932 1.10164151497509 0.558823529411765 26.1 26 1 increased inflammatory response 7.64317141078049e-06 0.0001854867208226 1.09981053184771 0.557894736842105 26.1 26 1 abnormal behavior 2.82995585087729e-14 3.70500798897751e-12 1.09913873228298 0.557553956834532 26.1 26 1 abnormal inflammatory response 0.000109106967423799 0.00186980231882994 1.0951991669343 0.555555555555556 26.1 26 1 increased circulating aspartate transaminase level 0.000287606297952178 0.0043004978269284 1.0951991669343 0.555555555555556 26.1 26 1 eye inflammation 0.0461589828940221 0.218715396794513 1.0951991669343 0.555555555555556 26.1 26 1 abnormal bile duct morphology 0.0461589828940221 0.218715396794513 1.0951991669343 0.555555555555556 26.1 26 1 long tibia 0.0461589828940221 0.218715396794513 1.0951991669343 0.555555555555556 26.1 26 1 abnormal neutrophil morphology 0.0461589828940221 0.218715396794513 1.0951991669343 0.555555555555556 26.1 26 1 jerky movement 0.0461589828940221 0.218715396794513 1.0951991669343 0.555555555555556 26.1 26 1 abnormal glycogen homeostasis 0.0461589828940221 0.218715396794513 1.0951991669343 0.555555555555556 26.1 26 1 abnormal pregnancy 0.0461589828940221 0.218715396794513 1.0951991669343 0.555555555555556 26.1 26 1 small thoracic cage 0.0461589828940221 0.218715396794513 1.0951991669343 0.555555555555556 26.1 26 1 primary atelectasis 0.0461589828940221 0.218715396794513 1.0951991669343 0.555555555555556 26.1 26 1 impaired leukocyte tethering or rolling 0.0461589828940221 0.218715396794513 1.0951991669343 0.555555555555556 26.1 26 1 increased adipocyte glucose uptake 0.0461589828940221 0.218715396794513 1.0951991669343 0.555555555555556 26.1 26 1 abnormal kindling response 0.149799521129013 0.457210194856958 1.0951991669343 0.555555555555556 26.1 26 1 multifocal hepatic necrosis 0.149799521129013 0.457210194856958 1.0951991669343 0.555555555555556 26.1 26 1 abnormal lung volume 0.149799521129013 0.457210194856958 1.0951991669343 0.555555555555556 26.1 26 1 increased pheochromocytoma incidence 0.149799521129013 0.457210194856958 1.0951991669343 0.555555555555556 26.1 26 1 abnormal germ cell morphology 0.149799521129013 0.457210194856958 1.0951991669343 0.555555555555556 26.1 26 1 abnormal thymus lobule morphology 0.149799521129013 0.457210194856958 1.0951991669343 0.555555555555556 26.1 26 1 abnormal posterior semicircular canal morphology 0.149799521129013 0.457210194856958 1.0951991669343 0.555555555555556 26.1 26 1 abnormal postural reflex 0.149799521129013 0.457210194856958 1.0951991669343 0.555555555555556 26.1 26 1 genetic imprinting 0.149799521129013 0.457210194856958 1.0951991669343 0.555555555555556 26.1 26 1 decreased susceptibility to induced choroidal neovascularization 0.149799521129013 0.457210194856958 1.0951991669343 0.555555555555556 26.1 26 1 decreased cochlear hair cell number 0.149799521129013 0.457210194856958 1.0951991669343 0.555555555555556 26.1 26 1 increased neuronal precursor cell number 0.149799521129013 0.457210194856958 1.0951991669343 0.555555555555556 26.1 26 1 liver hyperplasia 0.149799521129013 0.457210194856958 1.0951991669343 0.555555555555556 26.1 26 1 decreased susceptibility to atherosclerosis 0.149799521129013 0.457210194856958 1.0951991669343 0.555555555555556 26.1 26 1 positive geotaxis 0.149799521129013 0.457210194856958 1.0951991669343 0.555555555555556 26.1 26 1 abnormal optic chiasm morphology 0.149799521129013 0.457210194856958 1.0951991669343 0.555555555555556 26.1 26 1 abnormal hippocampus granule cell morphology 0.149799521129013 0.457210194856958 1.0951991669343 0.555555555555556 26.1 26 1 axonal spheroids 0.149799521129013 0.457210194856958 1.0951991669343 0.555555555555556 26.1 26 1 iris coloboma 0.149799521129013 0.457210194856958 1.0951991669343 0.555555555555556 26.1 26 1 abnormal heart left ventricle pressure 0.149799521129013 0.457210194856958 1.0951991669343 0.555555555555556 26.1 26 1 abnormal lung lobe morphology 0.149799521129013 0.457210194856958 1.0951991669343 0.555555555555556 26.1 26 1 reduced AMPA-mediated synaptic currents 0.149799521129013 0.457210194856958 1.0951991669343 0.555555555555556 26.1 26 1 decreased bone trabecular spacing 0.149799521129013 0.457210194856958 1.0951991669343 0.555555555555556 26.1 26 1 trigeminal neuroma 0.149799521129013 0.457210194856958 1.0951991669343 0.555555555555556 26.1 26 1 increased bone mineralization 0.149799521129013 0.457210194856958 1.0951991669343 0.555555555555556 26.1 26 1 enhanced leukocyte tethering or rolling 0.149799521129013 0.457210194856958 1.0951991669343 0.555555555555556 26.1 26 1 diluted coat color 0.000764496713754241 0.0100481028915643 1.0951991669343 0.555555555555556 26.1 26 1 decreased tumor growth/size 0.000764496713754241 0.0100481028915643 1.0951991669343 0.555555555555556 26.1 26 1 axon degeneration 0.000764496713754241 0.0100481028915643 1.0951991669343 0.555555555555556 26.1 26 1 abnormal heart valve morphology 0.0157470166593639 0.107464208340652 1.0951991669343 0.555555555555556 26.1 26 1 increased brain weight 0.0157470166593639 0.107464208340652 1.0951991669343 0.555555555555556 26.1 26 1 decreased circulating fructosamine level 0.0157470166593639 0.107464208340652 1.0951991669343 0.555555555555556 26.1 26 1 abnormal lipid homeostasis 2.88623000843749e-07 9.96193230917099e-06 1.09182932334373 0.553846153846154 26.1 26 1 azoospermia 1.53529634529112e-08 7.3443262671378e-07 1.09106633988926 0.553459119496855 26.1 26 1 abnormal craniofacial morphology 4.95113762708484e-06 0.000129641629972353 1.09094596628601 0.553398058252427 26.1 26 1 seizures 1.71756958378082e-06 4.93925357185525e-05 1.08943496079254 0.552631578947368 26.1 26 1 internal hemorrhage 0.000229625550502587 0.00355883836059306 1.08866066444514 0.552238805970149 26.1 26 1 dermatitis 0.000608332105421191 0.00829164993005596 1.0876460692313 0.551724137931034 26.1 26 1 ventricular septal defect 2.08470106008793e-07 7.57035603937039e-06 1.08714623188331 0.551470588235294 26.1 26 1 brain inflammation 0.0402761102640113 0.20680259985282 1.08424717526496 0.55 26.1 26 1 anencephaly 0.0402761102640113 0.20680259985282 1.08424717526496 0.55 26.1 26 1 abnormal trachea morphology 0.0402761102640113 0.20680259985282 1.08424717526496 0.55 26.1 26 1 decreased myocardial infarction size 0.0402761102640113 0.20680259985282 1.08424717526496 0.55 26.1 26 1 abnormal hyoid bone morphology 0.0402761102640113 0.20680259985282 1.08424717526496 0.55 26.1 26 1 abnormal optic stalk morphology 0.0402761102640113 0.20680259985282 1.08424717526496 0.55 26.1 26 1 abnormal sperm mitochondrial sheath morphology 0.0402761102640113 0.20680259985282 1.08424717526496 0.55 26.1 26 1 abnormal neural tube morphology 2.05153913517798e-08 9.38695909662014e-07 1.0830302873017 0.549382716049383 26.1 26 1 abnormal cervical vertebrae morphology 0.00144788563425794 0.0161575906185257 1.08231447085272 0.549019607843137 26.1 26 1 abnormal eyelid morphology 0.0122499803794197 0.0903684275895394 1.08106756478031 0.548387096774194 26.1 26 1 abnormal object recognition memory 0.0122499803794197 0.0903684275895394 1.08106756478031 0.548387096774194 26.1 26 1 premature death 3.85821344432411e-38 3.19910198091874e-35 1.08069827204109 0.548199767711963 26.1 26 1 enlarged kidney 0.00128728842997729 0.0148246757850394 1.07866785875416 0.547169811320755 26.1 26 1 abnormal axon morphology 5.89872885370677e-06 0.000152052725633115 1.07694584748539 0.546296296296296 26.1 26 1 osteoporosis 0.00347119860949544 0.033467467213643 1.07528645480822 0.545454545454545 26.1 26 1 renal interstitial fibrosis 0.00347119860949544 0.033467467213643 1.07528645480822 0.545454545454545 26.1 26 1 decreased macrophage cell number 0.00347119860949544 0.033467467213643 1.07528645480822 0.545454545454545 26.1 26 1 decreased blood urea nitrogen level 0.00347119860949544 0.033467467213643 1.07528645480822 0.545454545454545 26.1 26 1 enlarged pericardium 0.0108028014465744 0.0813070154261839 1.07528645480822 0.545454545454545 26.1 26 1 abnormal skeleton physiology 0.0108028014465744 0.0813070154261839 1.07528645480822 0.545454545454545 26.1 26 1 abnormal locomotor coordination 0.0108028014465744 0.0813070154261839 1.07528645480822 0.545454545454545 26.1 26 1 abnormal long bone epiphysis morphology 0.0351694617536381 0.195713727320302 1.07528645480822 0.545454545454545 26.1 26 1 parakeratosis 0.0351694617536381 0.195713727320302 1.07528645480822 0.545454545454545 26.1 26 1 abnormal female reproductive system physiology 0.0351694617536381 0.195713727320302 1.07528645480822 0.545454545454545 26.1 26 1 decreased circulating estradiol level 0.0351694617536381 0.195713727320302 1.07528645480822 0.545454545454545 26.1 26 1 increased mammary gland tumor incidence 0.0351694617536381 0.195713727320302 1.07528645480822 0.545454545454545 26.1 26 1 increased bone volume 0.0351694617536381 0.195713727320302 1.07528645480822 0.545454545454545 26.1 26 1 abnormal sebaceous gland morphology 0.126932830418062 0.404924011224745 1.07528645480822 0.545454545454545 26.1 26 1 abnormal glossopharyngeal ganglion morphology 0.126932830418062 0.404924011224745 1.07528645480822 0.545454545454545 26.1 26 1 abnormal food preference 0.126932830418062 0.404924011224745 1.07528645480822 0.545454545454545 26.1 26 1 retinal detachment 0.126932830418062 0.404924011224745 1.07528645480822 0.545454545454545 26.1 26 1 fused joints 0.126932830418062 0.404924011224745 1.07528645480822 0.545454545454545 26.1 26 1 pulmonary hypertension 0.126932830418062 0.404924011224745 1.07528645480822 0.545454545454545 26.1 26 1 dilated renal glomerular capsule 0.126932830418062 0.404924011224745 1.07528645480822 0.545454545454545 26.1 26 1 abnormal platelet aggregation 0.126932830418062 0.404924011224745 1.07528645480822 0.545454545454545 26.1 26 1 abnormal palate development 0.126932830418062 0.404924011224745 1.07528645480822 0.545454545454545 26.1 26 1 enhanced behavioral response to addictive substance 0.126932830418062 0.404924011224745 1.07528645480822 0.545454545454545 26.1 26 1 abnormal aorta smooth muscle morphology 0.126932830418062 0.404924011224745 1.07528645480822 0.545454545454545 26.1 26 1 palatal shelf hypoplasia 0.126932830418062 0.404924011224745 1.07528645480822 0.545454545454545 26.1 26 1 aberrant origin of the right subclavian artery 0.126932830418062 0.404924011224745 1.07528645480822 0.545454545454545 26.1 26 1 decreased embryonic cilium length 0.126932830418062 0.404924011224745 1.07528645480822 0.545454545454545 26.1 26 1 abnormal myocardium layer morphology 0.000115823892304185 0.00197336939799082 1.07301791798373 0.544303797468354 26.1 26 1 abnormal spermatogenesis 6.10485785169881e-09 3.16371539710433e-07 1.07139048939225 0.543478260869565 26.1 26 1 abnormal immune system morphology 0.00307565057421253 0.0302398450725441 1.07139048939225 0.543478260869565 26.1 26 1 embryonic lethality during organogenesis, incomplete penetrance 8.33844144814754e-11 6.01213713109189e-09 1.07139048939225 0.543478260869565 26.1 26 1 increased circulating alkaline phosphatase level 4.96851637062515e-08 2.18746627821771e-06 1.07086140766909 0.54320987654321 26.1 26 1 increased exploration in new environment 0.000103239029010306 0.00180215498009219 1.07086140766909 0.54320987654321 26.1 26 1 ovary cysts 0.00952667413383687 0.0729156981782129 1.07016604311866 0.542857142857143 26.1 26 1 decreased glycogen level 0.00952667413383687 0.0729156981782129 1.07016604311866 0.542857142857143 26.1 26 1 abnormal hippocampus pyramidal cell morphology 0.00952667413383687 0.0729156981782129 1.07016604311866 0.542857142857143 26.1 26 1 prenatal lethality, incomplete penetrance 1.02045838015847e-13 1.18064661425311e-11 1.0699807650641 0.542763157894737 26.1 26 1 abnormal neural tube closure 9.20022861854001e-05 0.00162886609883404 1.06880882556239 0.542168674698795 26.1 26 1 overriding aortic valve 0.00272479751407895 0.0275338279144105 1.06781918776094 0.541666666666667 26.1 26 1 curly vibrissae 0.030734161368818 0.176154899550541 1.06781918776094 0.541666666666667 26.1 26 1 increased circulating total protein level 0.030734161368818 0.176154899550541 1.06781918776094 0.541666666666667 26.1 26 1 abnormal truncus arteriosus septation 0.030734161368818 0.176154899550541 1.06781918776094 0.541666666666667 26.1 26 1 abnormal lung development 8.19729196718284e-05 0.00147759157741792 1.06685283555482 0.541176470588235 26.1 26 1 abnormal heart morphology 1.21630637350711e-10 8.6444631545684e-09 1.06675243532562 0.541125541125541 26.1 26 1 abnormal seminiferous tubule morphology 2.90347775845185e-07 9.96193230917099e-06 1.06669398313738 0.541095890410959 26.1 26 1 increased osteoclast cell number 0.000802357000046556 0.0104475973250167 1.06647263140815 0.540983606557377 26.1 26 1 abnormal branching of the mammary ductal tree 0.00840182921526162 0.0675268180063434 1.06559918944959 0.540540540540541 26.1 26 1 abnormal vocalization 0.00840182921526162 0.0675268180063434 1.06559918944959 0.540540540540541 26.1 26 1 increased circulating phosphate level 0.00840182921526162 0.0675268180063434 1.06559918944959 0.540540540540541 26.1 26 1 abnormal calcium ion homeostasis 0.00840182921526162 0.0675268180063434 1.06559918944959 0.540540540540541 26.1 26 1 skin inflammation 0.00840182921526162 0.0675268180063434 1.06559918944959 0.540540540540541 26.1 26 1 abnormal immune system physiology 2.39136176490166e-06 6.64638255887472e-05 1.06516951235707 0.540322580645161 26.1 26 1 abnormal muscle physiology 6.5041967798745e-05 0.00119403612471866 1.06320458452948 0.539325842696629 26.1 26 1 abnormal testis morphology 6.14738678353837e-06 0.000156036985959711 1.06281936547711 0.539130434782609 26.1 26 1 abnormal bone structure 5.68110993322467e-09 2.97510757029397e-07 1.06228644585544 0.538860103626943 26.1 26 1 abnormal glucose homeostasis 1.61764617886635e-08 7.5922544715661e-07 1.06150073102863 0.538461538461538 26.1 26 1 small spleen 5.79238812987186e-05 0.00107126880840567 1.06150073102863 0.538461538461538 26.1 26 1 ventricular hypoplasia 0.0268788464507029 0.157505607882505 1.06150073102863 0.538461538461538 26.1 26 1 absent myocardial trabeculae 0.108211443544337 0.368360047925194 1.06150073102863 0.538461538461538 26.1 26 1 uterus hypoplasia 0.108211443544337 0.368360047925194 1.06150073102863 0.538461538461538 26.1 26 1 tight skin 0.108211443544337 0.368360047925194 1.06150073102863 0.538461538461538 26.1 26 1 abnormal vertebral arch development 0.108211443544337 0.368360047925194 1.06150073102863 0.538461538461538 26.1 26 1 increased circulating thyroxine level 0.108211443544337 0.368360047925194 1.06150073102863 0.538461538461538 26.1 26 1 abnormal heart development 1.47378519146836e-07 5.96104172971959e-06 1.06054096544904 0.537974683544304 26.1 26 1 abnormal blood vessel morphology 4.72133423700955e-07 1.54530512033701e-05 1.06045491750052 0.537931034482759 26.1 26 1 insulin resistance 1.51671074285897e-06 4.43860937983728e-05 1.06035192071366 0.537878787878788 26.1 26 1 hypoglycemia 5.15779252714978e-05 0.00098554501708217 1.05987016154932 0.537634408602151 26.1 26 1 decreased platelet aggregation 0.00189372682079604 0.0203045063221127 1.05869252803649 0.537037037037037 26.1 26 1 abnormal mammary gland development 0.00653708631096694 0.0563639590936925 1.05780212220971 0.536585365853659 26.1 26 1 palatal shelves fail to meet at midline 0.00653708631096694 0.0563639590936925 1.05780212220971 0.536585365853659 26.1 26 1 increased bone trabecula number 0.00653708631096694 0.0563639590936925 1.05780212220971 0.536585365853659 26.1 26 1 small testis 6.35266560494875e-12 5.74627479720364e-10 1.05710528286702 0.536231884057971 26.1 26 1 prenatal lethality, complete penetrance 5.67393086133386e-12 5.22737148798814e-10 1.05659142651719 0.535971223021583 26.1 26 1 rib bifurcation 0.0235246028037861 0.140666945851966 1.05608491097236 0.535714285714286 26.1 26 1 failure of blastocyst to hatch from the zona pellucida 0.0235246028037861 0.140666945851966 1.05608491097236 0.535714285714286 26.1 26 1 enhanced coordination 0.0235246028037861 0.140666945851966 1.05608491097236 0.535714285714286 26.1 26 1 increased bone resorption 0.0235246028037861 0.140666945851966 1.05608491097236 0.535714285714286 26.1 26 1 impaired macrophage phagocytosis 0.00576742806550208 0.0506942661234502 1.05444757002512 0.534883720930233 26.1 26 1 delayed endochondral bone ossification 0.00576742806550208 0.0506942661234502 1.05444757002512 0.534883720930233 26.1 26 1 decreased oxygen consumption 0.00576742806550208 0.0506942661234502 1.05444757002512 0.534883720930233 26.1 26 1 decreased percent body fat/body weight 0.0003931911203227 0.00568641227792277 1.05319152765463 0.534246575342466 26.1 26 1 abnormal long bone epiphyseal plate morphology 0.00131583984519326 0.0150144569491662 1.05139120025693 0.533333333333333 26.1 26 1 abnormal incisor morphology 0.00131583984519326 0.0150144569491662 1.05139120025693 0.533333333333333 26.1 26 1 abnormal response to new environment 0.020603529544032 0.126158229015468 1.05139120025693 0.533333333333333 26.1 26 1 disorganized myocardium 0.020603529544032 0.126158229015468 1.05139120025693 0.533333333333333 26.1 26 1 abnormal epidermis stratum spinosum morphology 0.0926850544908753 0.363077280387484 1.05139120025693 0.533333333333333 26.1 26 1 abnormal seizure response to electrical stimulation 0.0926850544908753 0.363077280387484 1.05139120025693 0.533333333333333 26.1 26 1 absent egg cylinders 0.0926850544908753 0.363077280387484 1.05139120025693 0.533333333333333 26.1 26 1 increased airway responsiveness 0.0926850544908753 0.363077280387484 1.05139120025693 0.533333333333333 26.1 26 1 abnormal cricoid cartilage morphology 0.0926850544908753 0.363077280387484 1.05139120025693 0.533333333333333 26.1 26 1 joint inflammation 0.0926850544908753 0.363077280387484 1.05139120025693 0.533333333333333 26.1 26 1 abnormal zygomatic bone morphology 0.0926850544908753 0.363077280387484 1.05139120025693 0.533333333333333 26.1 26 1 decreased trabecular bone mass 0.0926850544908753 0.363077280387484 1.05139120025693 0.533333333333333 26.1 26 1 reduced male fertility 8.27126773295242e-10 5.01823865505345e-08 1.05081224034489 0.533039647577093 26.1 26 1 decreased body length 1.63969550321165e-11 1.37195952335711e-09 1.05043190171655 0.532846715328467 26.1 26 1 abnormal dendritic cell physiology 2.28268276367044e-05 0.000485313963643609 1.05016293950896 0.532710280373832 26.1 26 1 prenatal lethality 0.00116548971809984 0.0136110595012833 1.04927145993383 0.532258064516129 26.1 26 1 abnormal visceral yolk sac morphology 0.000275017163985534 0.00415869419704569 1.04806401291434 0.531645569620253 26.1 26 1 abnormal vertebral body morphology 0.0180572822505988 0.119779972262306 1.04728420338092 0.53125 26.1 26 1 bradykinesia 0.0180572822505988 0.119779972262306 1.04728420338092 0.53125 26.1 26 1 pancreatic islet hyperplasia 0.0180572822505988 0.119779972262306 1.04728420338092 0.53125 26.1 26 1 increased bone mineral density 1.6077714239521e-05 0.000363575583370986 1.04673902680446 0.530973451327434 26.1 26 1 abnormal skeleton development 0.000244111435918029 0.00375992072350524 1.04652364840389 0.530864197530864 26.1 26 1 decreased total body fat amount 2.33769545058965e-13 2.52826844927902e-11 1.04470195983613 0.529940119760479 26.1 26 1 small lung 0.00350029722017005 0.0336827440432224 1.04366038260798 0.529411764705882 26.1 26 1 abnormal oocyte morphology 0.0158357299498533 0.107921584247288 1.04366038260798 0.529411764705882 26.1 26 1 abnormal adipose tissue morphology 0.0796847735468926 0.32921381430938 1.04366038260798 0.529411764705882 26.1 26 1 abnormal bone marrow cavity morphology 0.0796847735468926 0.32921381430938 1.04366038260798 0.529411764705882 26.1 26 1 hyperlipidemia 0.0796847735468926 0.32921381430938 1.04366038260798 0.529411764705882 26.1 26 1 abnormal touch/ nociception 0.0796847735468926 0.32921381430938 1.04366038260798 0.529411764705882 26.1 26 1 decreased vasoconstriction 0.0796847735468926 0.32921381430938 1.04366038260798 0.529411764705882 26.1 26 1 abnormal involuntary movement 0.0796847735468926 0.32921381430938 1.04366038260798 0.529411764705882 26.1 26 1 increased circulating magnesium level 0.0796847735468926 0.32921381430938 1.04366038260798 0.529411764705882 26.1 26 1 abnormal survival 0.0796847735468926 0.32921381430938 1.04366038260798 0.529411764705882 26.1 26 1 increased trabecular bone mass 0.0796847735468926 0.32921381430938 1.04366038260798 0.529411764705882 26.1 26 1 abnormal cell cytoskeleton morphology 0.0796847735468926 0.32921381430938 1.04366038260798 0.529411764705882 26.1 26 1 abnormal uterus morphology 0.0138957691787968 0.0972312962932684 1.04043920858758 0.527777777777778 26.1 26 1 abnormal retinal blood vessel morphology 0.0138957691787968 0.0972312962932684 1.04043920858758 0.527777777777778 26.1 26 1 abnormal joint morphology 0.00272976641418353 0.0275338279144105 1.03944357298128 0.527272727272727 26.1 26 1 perinatal lethality, incomplete penetrance 2.9831487209529e-09 1.66754661648772e-07 1.03801620158109 0.526548672566372 26.1 26 1 decreased susceptibility to induced arthritis 0.00241129299643483 0.0246835034100067 1.0375571055167 0.526315789473684 26.1 26 1 abnormal facial morphology 0.00241129299643483 0.0246835034100067 1.0375571055167 0.526315789473684 26.1 26 1 enlarged adrenal glands 0.0687191327063236 0.299367500187356 1.0375571055167 0.526315789473684 26.1 26 1 shiny skin 0.0687191327063236 0.299367500187356 1.0375571055167 0.526315789473684 26.1 26 1 short vibrissae 0.0687191327063236 0.299367500187356 1.0375571055167 0.526315789473684 26.1 26 1 abnormal stationary movement 0.0687191327063236 0.299367500187356 1.0375571055167 0.526315789473684 26.1 26 1 stereotypic behavior 0.0687191327063236 0.299367500187356 1.0375571055167 0.526315789473684 26.1 26 1 abnormal optic vesicle formation 0.0687191327063236 0.299367500187356 1.0375571055167 0.526315789473684 26.1 26 1 decreased eye pigmentation 0.0687191327063236 0.299367500187356 1.0375571055167 0.526315789473684 26.1 26 1 decreased circulating magnesium level 0.0687191327063236 0.299367500187356 1.0375571055167 0.526315789473684 26.1 26 1 enlarged heart 2.10837720055327e-09 1.234020773265e-07 1.03666265973609 0.525862068965517 26.1 26 1 decreased body weight 2.78326416014027e-44 2.76934783933957e-41 1.03663520501907 0.525848142164782 26.1 26 1 increased rib number 0.000442187954609099 0.00626747884381843 1.03622690409938 0.525641025641026 26.1 26 1 increased hemoglobin content 0.00213034107210573 0.0221724829157447 1.03579853415142 0.525423728813559 26.1 26 1 reduced fertility 3.50503442198769e-06 9.32489104245389e-05 1.03531777363429 0.525179856115108 26.1 26 1 abnormal eye morphology 3.50503442198769e-06 9.32489104245389e-05 1.03531777363429 0.525179856115108 26.1 26 1 abnormal liver morphology 1.51807908686728e-07 6.04195476573176e-06 1.03523854215242 0.525139664804469 26.1 26 1 abnormal female reproductive system morphology 0.0107173436458314 0.0810315875957615 1.03496321275291 0.525 26.1 26 1 increased insulin sensitivity 2.77169771903711e-06 7.61834041558544e-05 1.03392928346944 0.524475524475524 26.1 26 1 abnormal salivary gland morphology 0.0594154187231581 0.265342646452165 1.0326163573952 0.523809523809524 26.1 26 1 abnormal associative learning 0.0594154187231581 0.265342646452165 1.0326163573952 0.523809523809524 26.1 26 1 increased keratinocyte proliferation 0.0594154187231581 0.265342646452165 1.0326163573952 0.523809523809524 26.1 26 1 vascular ring 0.0594154187231581 0.265342646452165 1.0326163573952 0.523809523809524 26.1 26 1 edema 3.40274454912203e-07 1.15160912461783e-05 1.0315247967637 0.523255813953488 26.1 26 1 increased oxygen consumption 0.000272732817602669 0.00413672490113804 1.0315247967637 0.523255813953488 26.1 26 1 abnormal astrocyte morphology 0.00828234604112839 0.0671085855938335 1.03048285252454 0.522727272727273 26.1 26 1 muscular atrophy 0.00828234604112839 0.0671085855938335 1.03048285252454 0.522727272727273 26.1 26 1 cochlear hair cell degeneration 0.00828234604112839 0.0671085855938335 1.03048285252454 0.522727272727273 26.1 26 1 decreased white adipose tissue amount 0.00130005366368633 0.014902688886727 1.0298141420427 0.522388059701492 26.1 26 1 thin ventricular wall 0.00021426975350218 0.00339487905628454 1.02948721691824 0.522222222222222 26.1 26 1 increased susceptibility to parasitic infection 0.00021426975350218 0.00339487905628454 1.02948721691824 0.522222222222222 26.1 26 1 limb grasping 1.89553833528983e-07 7.07008596985787e-06 1.02900581069102 0.521978021978022 26.1 26 1 abnormal cranial nerve morphology 0.0514840971848425 0.235416712770764 1.02853486981656 0.521739130434783 26.1 26 1 conjunctivitis 0.0514840971848425 0.235416712770764 1.02853486981656 0.521739130434783 26.1 26 1 pancreas inflammation 0.0514840971848425 0.235416712770764 1.02853486981656 0.521739130434783 26.1 26 1 dilated heart 0.0514840971848425 0.235416712770764 1.02853486981656 0.521739130434783 26.1 26 1 abnormal chondrocyte physiology 0.0514840971848425 0.235416712770764 1.02853486981656 0.521739130434783 26.1 26 1 postnatal growth retardation 2.05115345597845e-21 6.80299229566185e-19 1.027554512506 0.52124183006536 26.1 26 1 abnormal skeletal muscle fiber morphology 0.00101653413926611 0.012186162271925 1.02732766926513 0.52112676056338 26.1 26 1 enlarged liver 0.000117347299348648 0.0019857238580256 1.0251064202505 0.52 26.1 26 1 abnormal liver physiology 0.000117347299348648 0.0019857238580256 1.0251064202505 0.52 26.1 26 1 abnormal circulating protein level 0.00564491772642398 0.0498818218276364 1.0251064202505 0.52 26.1 26 1 abnormal preimplantation embryo development 0.0446959913382433 0.218715396794513 1.0251064202505 0.52 26.1 26 1 kinked tail 0.000104052125634415 0.00180999763996928 1.02433333848561 0.519607843137255 26.1 26 1 decreased bone mineral content 4.13392087946054e-08 1.83627289065323e-06 1.02358999063475 0.519230769230769 26.1 26 1 abnormal skin condition 0.00497155513239946 0.0442459513124996 1.02358999063475 0.519230769230769 26.1 26 1 abnormal nervous system morphology 0.000622556439229253 0.0084163540357759 1.02311010784495 0.518987341772152 26.1 26 1 increased cell proliferation 0.00438004353236286 0.0391919362832828 1.02218588913868 0.518518518518518 26.1 26 1 thick interventricular septum 0.0388669708413756 0.202262740518665 1.02218588913868 0.518518518518518 26.1 26 1 decreased bone ossification 0.0388669708413756 0.202262740518665 1.02218588913868 0.518518518518518 26.1 26 1 short sternum 0.0338472970882228 0.190056775410732 1.01966818990435 0.517241379310345 26.1 26 1 polychromatophilia 0.0338472970882228 0.190056775410732 1.01966818990435 0.517241379310345 26.1 26 1 lethargy 0.0002652131269446 0.0040473475661024 1.01747535508735 0.516129032258065 26.1 26 1 abnormal postnatal growth/weight/body size 0.0295139819862851 0.16994451433075 1.01747535508735 0.516129032258065 26.1 26 1 abnormal capillary morphology 0.0295139819862851 0.16994451433075 1.01747535508735 0.516129032258065 26.1 26 1 small cranium 0.0295139819862851 0.16994451433075 1.01747535508735 0.516129032258065 26.1 26 1 abnormal tooth development 0.0257651681048748 0.151862891514971 1.01554831842999 0.515151515151515 26.1 26 1 abnormal ovarian folliculogenesis 0.0257651681048748 0.151862891514971 1.01554831842999 0.515151515151515 26.1 26 1 abnormal cranium morphology 1.53004299170373e-05 0.000349172655216792 1.01510251144209 0.514925373134328 26.1 26 1 male infertility 8.73766890941268e-17 1.73879611297312e-14 1.01507326366754 0.514910536779324 26.1 26 1 thick pulmonary interalveolar septum 0.0225159066962235 0.135777740380257 1.01384151453347 0.514285714285714 26.1 26 1 decreased bone mineralization 0.0225159066962235 0.135777740380257 1.01384151453347 0.514285714285714 26.1 26 1 decreased hematocrit 7.47717263390889e-06 0.000182347714969102 1.01268416120637 0.513698630136986 26.1 26 1 malocclusion 0.019694928029195 0.126158229015468 1.01231922997711 0.513513513513513 26.1 26 1 decreased width of hypertrophic chondrocyte zone 0.019694928029195 0.126158229015468 1.01231922997711 0.513513513513513 26.1 26 1 abnormal axial skeleton morphology 0.0011075755870978 0.0130264504629115 1.01161817787879 0.513157894736842 26.1 26 1 impaired macrophage chemotaxis 0.017242132252977 0.115140413367195 1.01095307717012 0.512820512820513 26.1 26 1 abnormal posture 0.000865112631670278 0.0111326288390138 1.01032123149689 0.5125 26.1 26 1 Leydig cell hyperplasia 0.0151066138474391 0.104527682741321 1.00972020756382 0.51219512195122 26.1 26 1 increased tumor growth/size 0.0151066138474391 0.104527682741321 1.00972020756382 0.51219512195122 26.1 26 1 perinatal lethality, complete penetrance 9.64754211019128e-08 3.9997101665168e-06 1.0088172608099 0.511737089201878 26.1 26 1 abnormal left-right axis patterning 0.013245088085879 0.0929397929862454 1.00860202350228 0.511627906976744 26.1 26 1 abnormal homeostasis 0.013245088085879 0.0929397929862454 1.00860202350228 0.511627906976744 26.1 26 1 decreased body size 6.87749306476019e-25 2.85129399976516e-22 1.00791261678766 0.511278195488722 26.1 26 1 irregular heartbeat 0.0116206250021634 0.0865458224337766 1.00758323357955 0.511111111111111 26.1 26 1 abnormal cell migration 0.0116206250021634 0.0865458224337766 1.00758323357955 0.511111111111111 26.1 26 1 increased heart weight 1.65647238023826e-05 0.000369549331465709 1.00695290312377 0.510791366906475 26.1 26 1 decreased bone trabecula number 0.0102016217374198 0.0773674819263161 1.00665114918216 0.51063829787234 26.1 26 1 postnatal lethality, complete penetrance 1.18236672525028e-12 1.22547384544169e-10 1.00610783573809 0.510362694300518 26.1 26 1 increased circulating LDL cholesterol level 0.00896096188153285 0.0705392173427626 1.00579515330701 0.510204081632653 26.1 26 1 abnormal thrombosis 0.00787532305292809 0.0645465110186446 1.00500629436324 0.509803921568627 26.1 26 1 abnormal enzyme/coenzyme activity 5.6446214377117e-06 0.000147026134306889 1.00451388559579 0.509554140127389 26.1 26 1 abnormal placenta development 0.00692460310020425 0.0590907382907652 1.00427697194353 0.509433962264151 26.1 26 1 increased circulating bilirubin level 0.00692460310020425 0.0590907382907652 1.00427697194353 0.509433962264151 26.1 26 1 abnormal brain morphology 4.44567486997363e-06 0.000117022394064121 1.00404594434474 0.509316770186335 26.1 26 1 abnormal craniofacial bone morphology 0.00536082173117664 0.0474556727982274 1.00297186866615 0.508771929824561 26.1 26 1 lung inflammation 2.87510777024776e-05 0.000579095593400106 1.00017453333265 0.507352941176471 26.1 26 1 abnormal ovary morphology 0.00221394039974776 0.0228988638019649 0.99956205658229 0.507042253521127 26.1 26 1 increased circulating free fatty acid level 0.00221394039974776 0.0228988638019649 0.99956205658229 0.507042253521127 26.1 26 1 decreased liver weight 0.00221394039974776 0.0228988638019649 0.99956205658229 0.507042253521127 26.1 26 1 decreased heart weight 0.00118716395726804 0.0138317112117295 0.997848129873472 0.506172839506173 26.1 26 1 small ovary 0.000639959121489574 0.00862817514745428 0.996510890353406 0.505494505494505 26.1 26 1 ataxia 5.56934415577825e-07 1.8109468741828e-05 0.995438450738303 0.504950495049505 26.1 26 1 decreased anxiety-related response 9.08176423818749e-05 0.00161886305422569 0.993692902681851 0.504065040650406 26.1 26 1 increased circulating triglyceride level 2.40765306030697e-05 0.000504666265275294 0.992477038173565 0.503448275862069 26.1 26 1 cleft secondary palate 0.000765473567015656 0.0100481028915643 0.985679250240869 0.5 26.1 26 1 increased susceptibility to bacterial infection induced morbidity/mortality 0.00300879206682435 0.0297589274999028 0.985679250240869 0.5 26.1 26 1 intracranial hemorrhage 0.00643844414628844 0.055803588201716 0.985679250240869 0.5 26.1 26 1 abnormal kidney physiology 0.0139913957029767 0.0977629123908834 0.985679250240869 0.5 26.1 26 1 reduced long term depression 0.0311360442136503 0.178252957379644 0.985679250240869 0.5 26.1 26 1 abnormal brown adipose tissue morphology 0.035694606259896 0.198192707748865 0.985679250240869 0.5 26.1 26 1 liver hemorrhage 0.0470910646324136 0.218715396794513 0.985679250240869 0.5 26.1 26 1 abnormal fat pad morphology 0.0470910646324136 0.218715396794513 0.985679250240869 0.5 26.1 26 1 abnormal somite shape 0.054209338878965 0.244729093396416 0.985679250240869 0.5 26.1 26 1 increased triglyceride level 0.054209338878965 0.244729093396416 0.985679250240869 0.5 26.1 26 1 corneal vascularization 0.054209338878965 0.244729093396416 0.985679250240869 0.5 26.1 26 1 abnormal nasal bone morphology 0.0625131362257838 0.275467540056045 0.985679250240869 0.5 26.1 26 1 pulmonary edema 0.0625131362257838 0.275467540056045 0.985679250240869 0.5 26.1 26 1 abnormal nerve conduction 0.0625131362257838 0.275467540056045 0.985679250240869 0.5 26.1 26 1 abnormal adrenal gland morphology 0.0722340330008669 0.308732228676386 0.985679250240869 0.5 26.1 26 1 blindness 0.0722340330008669 0.308732228676386 0.985679250240869 0.5 26.1 26 1 prolonged QT interval 0.0722340330008669 0.308732228676386 0.985679250240869 0.5 26.1 26 1 abnormal cellular extravasation 0.0722340330008669 0.308732228676386 0.985679250240869 0.5 26.1 26 1 abnormal enterocyte morphology 0.0836613756926778 0.34004521574434 0.985679250240869 0.5 26.1 26 1 abnormal facial nerve morphology 0.0836613756926778 0.34004521574434 0.985679250240869 0.5 26.1 26 1 abnormal chorion morphology 0.0836613756926778 0.34004521574434 0.985679250240869 0.5 26.1 26 1 increased myocardial infarction size 0.0836613756926778 0.34004521574434 0.985679250240869 0.5 26.1 26 1 abnormal retinal layer morphology 0.0836613756926778 0.34004521574434 0.985679250240869 0.5 26.1 26 1 prolonged PR interval 0.0836613756926778 0.34004521574434 0.985679250240869 0.5 26.1 26 1 abnormal limb posture 0.0836613756926778 0.34004521574434 0.985679250240869 0.5 26.1 26 1 cleft upper lip 0.0836613756926778 0.34004521574434 0.985679250240869 0.5 26.1 26 1 failure of palatal shelf elevation 0.0836613756926778 0.34004521574434 0.985679250240869 0.5 26.1 26 1 abnormal pericardium morphology 0.0971621551486359 0.368360047925194 0.985679250240869 0.5 26.1 26 1 cortical renal glomerulopathies 0.113210564199763 0.368360047925194 0.985679250240869 0.5 26.1 26 1 abnormal radius morphology 0.113210564199763 0.368360047925194 0.985679250240869 0.5 26.1 26 1 blepharoptosis 0.113210564199763 0.368360047925194 0.985679250240869 0.5 26.1 26 1 abnormal circulating enzyme level 0.0971621551486359 0.368360047925194 0.985679250240869 0.5 26.1 26 1 absent allantois 0.113210564199763 0.368360047925194 0.985679250240869 0.5 26.1 26 1 decreased activity of thyroid 0.113210564199763 0.368360047925194 0.985679250240869 0.5 26.1 26 1 abnormal response to tactile stimuli 0.0971621551486359 0.368360047925194 0.985679250240869 0.5 26.1 26 1 darkened coat color 0.113210564199763 0.368360047925194 0.985679250240869 0.5 26.1 26 1 abnormal blood flow velocity 0.155686633156861 0.468283554991162 0.985679250240869 0.5 26.1 26 1 increased aggression towards males 0.155686633156861 0.468283554991162 0.985679250240869 0.5 26.1 26 1 absent visceral yolk sac blood islands 0.155686633156861 0.468283554991162 0.985679250240869 0.5 26.1 26 1 absent otoliths 0.155686633156861 0.468283554991162 0.985679250240869 0.5 26.1 26 1 abnormal voluntary movement 0.155686633156861 0.468283554991162 0.985679250240869 0.5 26.1 26 1 abnormal sagittal suture morphology 0.155686633156861 0.468283554991162 0.985679250240869 0.5 26.1 26 1 decreased CNS synapse formation 0.155686633156861 0.468283554991162 0.985679250240869 0.5 26.1 26 1 abnormal supraoccipital bone morphology 0.184180771956544 0.52995913272632 0.985679250240869 0.5 26.1 26 1 absent optic nerve 0.184180771956544 0.52995913272632 0.985679250240869 0.5 26.1 26 1 abnormal mating frequency 0.184180771956544 0.52995913272632 0.985679250240869 0.5 26.1 26 1 abnormal pilomotor reflex 0.184180771956544 0.52995913272632 0.985679250240869 0.5 26.1 26 1 abnormal tracheal ciliated epithelium morphology 0.184180771956544 0.52995913272632 0.985679250240869 0.5 26.1 26 1 abnormal AMPA-mediated synaptic currents 0.184180771956544 0.52995913272632 0.985679250240869 0.5 26.1 26 1 small thyroid gland 0.184180771956544 0.52995913272632 0.985679250240869 0.5 26.1 26 1 loss of dopaminergic neurons 0.184180771956544 0.52995913272632 0.985679250240869 0.5 26.1 26 1 small intestinal inflammation 0.184180771956544 0.52995913272632 0.985679250240869 0.5 26.1 26 1 decreased circulating ketone body level 0.184180771956544 0.52995913272632 0.985679250240869 0.5 26.1 26 1 absent ovary 0.184180771956544 0.52995913272632 0.985679250240869 0.5 26.1 26 1 decreased left ventricle systolic pressure 0.184180771956544 0.52995913272632 0.985679250240869 0.5 26.1 26 1 abnormal cochlear outer hair cell physiology 0.184180771956544 0.52995913272632 0.985679250240869 0.5 26.1 26 1 hemoperitoneum 0.184180771956544 0.52995913272632 0.985679250240869 0.5 26.1 26 1 impaired behavioral response to cocaine 0.184180771956544 0.52995913272632 0.985679250240869 0.5 26.1 26 1 enlarged testis 0.219727469620555 0.588028058828542 0.985679250240869 0.5 26.1 26 1 abnormal prostate gland epithelium morphology 0.219727469620555 0.588028058828542 0.985679250240869 0.5 26.1 26 1 decreased incidence of induced tumors 0.219727469620555 0.588028058828542 0.985679250240869 0.5 26.1 26 1 ketoaciduria 0.219727469620555 0.588028058828542 0.985679250240869 0.5 26.1 26 1 abnormal PNS synaptic transmission 0.219727469620555 0.588028058828542 0.985679250240869 0.5 26.1 26 1 delayed dark adaptation 0.219727469620555 0.588028058828542 0.985679250240869 0.5 26.1 26 1 increased natural killer cell mediated cytotoxicity 0.219727469620555 0.588028058828542 0.985679250240869 0.5 26.1 26 1 aneurysm 0.219727469620555 0.588028058828542 0.985679250240869 0.5 26.1 26 1 peritoneal inflammation 0.219727469620555 0.588028058828542 0.985679250240869 0.5 26.1 26 1 abnormal deltoid tuberosity morphology 0.219727469620555 0.588028058828542 0.985679250240869 0.5 26.1 26 1 abnormal cochlear inner hair cell physiology 0.219727469620555 0.588028058828542 0.985679250240869 0.5 26.1 26 1 increased susceptibility to atherosclerosis 0.219727469620555 0.588028058828542 0.985679250240869 0.5 26.1 26 1 osteosclerosis 0.219727469620555 0.588028058828542 0.985679250240869 0.5 26.1 26 1 tachypnea 0.219727469620555 0.588028058828542 0.985679250240869 0.5 26.1 26 1 abnormal developmental vascular remodeling 0.219727469620555 0.588028058828542 0.985679250240869 0.5 26.1 26 1 abnormal cerebellar granule cell migration 0.219727469620555 0.588028058828542 0.985679250240869 0.5 26.1 26 1 increased serotonin level 0.219727469620555 0.588028058828542 0.985679250240869 0.5 26.1 26 1 abnormal heart and great artery attachment 0.219727469620555 0.588028058828542 0.985679250240869 0.5 26.1 26 1 common ventricle 0.219727469620555 0.588028058828542 0.985679250240869 0.5 26.1 26 1 thick aortic valve 0.219727469620555 0.588028058828542 0.985679250240869 0.5 26.1 26 1 fusion of atlas and odontoid process 0.219727469620555 0.588028058828542 0.985679250240869 0.5 26.1 26 1 decreased circulating lactate level 0.219727469620555 0.588028058828542 0.985679250240869 0.5 26.1 26 1 abnormal motor capabilities/coordination/movement 7.53832860342265e-05 0.00136872937233678 0.985679250240869 0.5 26.1 26 1 decreased circulating HDL cholesterol level 9.60336976892213e-05 0.0016882248975402 0.985679250240869 0.5 26.1 26 1 abnormal locomotor behavior 0.000865995449386601 0.0111326288390138 0.985679250240869 0.5 26.1 26 1 sparse hair 0.00160954311966178 0.0175745423432606 0.985679250240869 0.5 26.1 26 1 decreased circulating LDL cholesterol level 0.00498917903644303 0.0443235101898287 0.985679250240869 0.5 26.1 26 1 abnormal maxilla morphology 0.0094691626680456 0.0728115676561466 0.985679250240869 0.5 26.1 26 1 decreased respiratory quotient 0.0122770060366417 0.0903684275895394 0.985679250240869 0.5 26.1 26 1 abnormal myelin sheath morphology 0.0159554304668147 0.108440254880332 0.985679250240869 0.5 26.1 26 1 atrial septal defect 0.0159554304668147 0.108440254880332 0.985679250240869 0.5 26.1 26 1 disheveled coat 0.0207939191543082 0.126158229015468 0.985679250240869 0.5 26.1 26 1 abnormal pancreas morphology 0.0207939191543082 0.126158229015468 0.985679250240869 0.5 26.1 26 1 spina bifida 0.0207939191543082 0.126158229015468 0.985679250240869 0.5 26.1 26 1 increased bone marrow cell number 0.0271895572152117 0.159138878994916 0.985679250240869 0.5 26.1 26 1 kidney cortex cysts 0.0409706817219712 0.207354162326355 0.985679250240869 0.5 26.1 26 1 increased circulating follicle stimulating hormone level 0.0409706817219712 0.207354162326355 0.985679250240869 0.5 26.1 26 1 neonatal lethality 0.0409706817219712 0.207354162326355 0.985679250240869 0.5 26.1 26 1 abnormal heart atrium morphology 0.0409706817219712 0.207354162326355 0.985679250240869 0.5 26.1 26 1 abnormal depression-related behavior 0.0409706817219712 0.207354162326355 0.985679250240869 0.5 26.1 26 1 failure of tooth eruption 0.132433794459185 0.417262905278306 0.985679250240869 0.5 26.1 26 1 vasculature congestion 0.132433794459185 0.417262905278306 0.985679250240869 0.5 26.1 26 1 abnormal mouth morphology 0.132433794459185 0.417262905278306 0.985679250240869 0.5 26.1 26 1 mixed cellular infiltration to dermis 0.132433794459185 0.417262905278306 0.985679250240869 0.5 26.1 26 1 disorganized retinal layers 0.132433794459185 0.417262905278306 0.985679250240869 0.5 26.1 26 1 abnormal epicardium morphology 0.132433794459185 0.417262905278306 0.985679250240869 0.5 26.1 26 1 increased thymus weight 0.132433794459185 0.417262905278306 0.985679250240869 0.5 26.1 26 1 sepsis 0.132433794459185 0.417262905278306 0.985679250240869 0.5 26.1 26 1 decreased circulating prolactin level 0.132433794459185 0.417262905278306 0.985679250240869 0.5 26.1 26 1 blepharitis 0.132433794459185 0.417262905278306 0.985679250240869 0.5 26.1 26 1 decreased fibroblast apoptosis 0.132433794459185 0.417262905278306 0.985679250240869 0.5 26.1 26 1 decreased grip strength 5.84029127360988e-07 1.88671747313046e-05 0.981178431746618 0.497716894977169 26.1 26 1 impaired coordination 4.44288584787982e-10 2.87056585626001e-08 0.979981682320401 0.497109826589595 26.1 26 1 no abnormal phenotype detected 3.76943374953667e-45 6.25097763464832e-42 0.978293757299583 0.496253602305475 26.1 26 1 neonatal lethality, incomplete penetrance 7.2197180053368e-08 3.09638767901298e-06 0.978097102162093 0.496153846153846 26.1 26 1 hyperactivity 1.42577407311935e-10 9.85170279690105e-09 0.977708798082587 0.495956873315364 26.1 26 1 decreased startle reflex 0.000266180268856347 0.00404968451853311 0.977254641264451 0.495726495726496 26.1 26 1 abnormal vertebrae morphology 0.000433760075846203 0.00616558964952818 0.976636321339577 0.495412844036697 26.1 26 1 abnormal neuron morphology 0.000801074859401531 0.0104475973250167 0.97572289417783 0.494949494949495 26.1 26 1 abnormal myocardial fiber morphology 0.000906066893678397 0.0114160541688403 0.975517608485808 0.494845360824742 26.1 26 1 hunched posture 0.00276900530878379 0.0275516028223988 0.973202297706174 0.493670886075949 26.1 26 1 rib fusion 0.0058974424743477 0.0516805401113366 0.970967619640259 0.492537313432836 26.1 26 1 decreased circulating cholesterol level 9.87543991131314e-06 0.000235073270616186 0.969520574007412 0.491803278688525 26.1 26 1 abnormal male meiosis 0.00864641548537477 0.0692037848812787 0.969520574007412 0.491803278688525 26.1 26 1 abnormal thoracic vertebrae morphology 0.00983074742493178 0.0750122215322632 0.968972822270685 0.491525423728814 26.1 26 1 weight loss 1.59308018893355e-05 0.00036189835342212 0.968781891665311 0.491428571428571 26.1 26 1 reduced female fertility 7.4681919066088e-07 2.3515351098341e-05 0.96868478040913 0.491379310344828 26.1 26 1 abnormal head morphology 0.0127262504307033 0.0903684275895394 0.967757809327399 0.490909090909091 26.1 26 1 abnormal cued conditioning behavior 0.0165093935209817 0.111899499682403 0.966352206118499 0.490196078431373 26.1 26 1 abnormal response to novel object 0.0165093935209817 0.111899499682403 0.966352206118499 0.490196078431373 26.1 26 1 polydactyly 0.00120143837583617 0.0139653175695909 0.965563347174729 0.489795918367347 26.1 26 1 retinal degeneration 0.00135903732259471 0.0153712812188815 0.965144265860851 0.489583333333333 26.1 26 1 abnormal rib morphology 0.000176267005199021 0.00288463273310898 0.963775266902183 0.488888888888889 26.1 26 1 albuminuria 0.024508635036119 0.146375101206113 0.963775266902183 0.488888888888889 26.1 26 1 female infertility 1.92989343944541e-07 7.1120147120303e-06 0.963445883694082 0.488721804511278 26.1 26 1 increased circulating creatinine level 0.00252400870495366 0.0257314412031648 0.962756476979453 0.488372093023256 26.1 26 1 abnormal male reproductive system morphology 0.0279996215378091 0.163687564219272 0.962756476979453 0.488372093023256 26.1 26 1 arrest of spermatogenesis 0.0028584543264302 0.0283848508462879 0.962210696663705 0.488095238095238 26.1 26 1 thick ventricular wall 0.0320148323007732 0.182444204692264 0.961638292917921 0.48780487804878 26.1 26 1 liver fibrosis 0.0320148323007732 0.182444204692264 0.961638292917921 0.48780487804878 26.1 26 1 lethality at weaning, incomplete penetrance 0.0320148323007732 0.182444204692264 0.961638292917921 0.48780487804878 26.1 26 1 abnormal bone mineralization 0.000411665531554081 0.00591917924705651 0.9612409217225 0.487603305785124 26.1 26 1 abnormal cornea morphology 0.00415785778141984 0.038164838491815 0.960405423311616 0.487179487179487 26.1 26 1 increased circulating alanine transaminase level 0.00415785778141984 0.038164838491815 0.960405423311616 0.487179487179487 26.1 26 1 abnormal heart looping 0.0366396109293347 0.198748486740044 0.960405423311616 0.487179487179487 26.1 26 1 impaired skeletal muscle contractility 0.0419749963883974 0.211361950437527 0.959039270504629 0.486486486486487 26.1 26 1 increased circulating HDL cholesterol level 0.00109223243759527 0.0128764369124087 0.957516985948273 0.485714285714286 26.1 26 1 thick epidermis 0.00687862825539939 0.0589004743039793 0.957516985948273 0.485714285714286 26.1 26 1 abnormal dermal layer morphology 0.0481411558478092 0.22217277397296 0.957516985948273 0.485714285714286 26.1 26 1 abnormal midbrain development 0.0481411558478092 0.22217277397296 0.957516985948273 0.485714285714286 26.1 26 1 increased red blood cell distribution width 0.0481411558478092 0.22217277397296 0.957516985948273 0.485714285714286 26.1 26 1 decreased bone volume 0.0481411558478092 0.22217277397296 0.957516985948273 0.485714285714286 26.1 26 1 abnormal skin morphology 0.00886430528231313 0.0698889362591249 0.955810182051752 0.484848484848485 26.1 26 1 increased osteoblast cell number 0.0552817533615919 0.248892961967348 0.955810182051752 0.484848484848485 26.1 26 1 increased sacral vertebrae number 0.0100681863896796 0.0767063205033019 0.954876773670842 0.484375 26.1 26 1 increased lung adenoma incidence 0.0635695796131588 0.27938044043769 0.953883145394389 0.483870967741935 26.1 26 1 abnormal nose morphology 0.0635695796131588 0.27938044043769 0.953883145394389 0.483870967741935 26.1 26 1 abnormal locomotor activation 0.00258404328926372 0.0262896019715481 0.953184329903258 0.483516483516484 26.1 26 1 abnormal eating behavior 0.0130041924275336 0.0915075775487689 0.95282327523284 0.483333333333333 26.1 26 1 abnormal retinal pigmentation 0.00331005683326602 0.0321725678673037 0.951690310577391 0.482758620689655 26.1 26 1 decreased trophoblast giant cell number 0.073213911216991 0.310784307427073 0.951690310577391 0.482758620689655 26.1 26 1 increased susceptibility to induced arthritis 0.073213911216991 0.310784307427073 0.951690310577391 0.482758620689655 26.1 26 1 abnormal seminal vesicle morphology 0.0168261079648771 0.113736259681065 0.950476419875124 0.482142857142857 26.1 26 1 enhanced long term potentiation 0.0168261079648771 0.113736259681065 0.950476419875124 0.482142857142857 26.1 26 1 abnormal trigeminal ganglion morphology 0.0844702897970202 0.342493636300061 0.949172611343059 0.481481481481481 26.1 26 1 thin epidermis 0.0844702897970202 0.342493636300061 0.949172611343059 0.481481481481481 26.1 26 1 abnormal skin appearance 0.0844702897970202 0.342493636300061 0.949172611343059 0.481481481481481 26.1 26 1 increased or absent threshold for auditory brainstem response 2.45976722053963e-07 8.74095851584618e-06 0.948162046944504 0.480968858131488 26.1 26 1 abnormal female meiosis 0.0218152292131344 0.132032561235211 0.947768509846989 0.480769230769231 26.1 26 1 hypoactivity 4.94120894041026e-09 2.64328112672484e-07 0.946461242936856 0.480106100795756 26.1 26 1 abnormal kidney morphology 5.83124578674866e-05 0.00107446102922498 0.946252080231234 0.48 26.1 26 1 abnormal cochlear outer hair cell morphology 0.0976537637663654 0.368360047925194 0.946252080231234 0.48 26.1 26 1 abnormal vertebrae development 0.0976537637663654 0.368360047925194 0.946252080231234 0.48 26.1 26 1 increased liver glycogen level 0.0976537637663654 0.368360047925194 0.946252080231234 0.48 26.1 26 1 cataract 0.000787321739792671 0.0103076990933383 0.944948702710254 0.479338842975207 26.1 26 1 abnormal intestinal epithelium morphology 0.0283493505116325 0.16495674712909 0.944609281480833 0.479166666666667 26.1 26 1 oligodactyly 0.0283493505116325 0.16495674712909 0.944609281480833 0.479166666666667 26.1 26 1 abnormal nervous system physiology 0.00113208276694312 0.013283282465901 0.942823630665179 0.478260869565217 26.1 26 1 abnormal sleep pattern 0.0323490725579812 0.183717620977119 0.942823630665179 0.478260869565217 26.1 26 1 abnormal blood vessel physiology 0.11315721432486 0.368360047925194 0.942823630665179 0.478260869565217 26.1 26 1 bidirectional circling 0.11315721432486 0.368360047925194 0.942823630665179 0.478260869565217 26.1 26 1 abnormal circulating insulin level 0.11315721432486 0.368360047925194 0.942823630665179 0.478260869565217 26.1 26 1 abnormal cardiovascular development 0.11315721432486 0.368360047925194 0.942823630665179 0.478260869565217 26.1 26 1 abnormal ulna morphology 0.11315721432486 0.368360047925194 0.942823630665179 0.478260869565217 26.1 26 1 abnormal lens development 0.11315721432486 0.368360047925194 0.942823630665179 0.478260869565217 26.1 26 1 decreased insulin secretion 0.00379815435592454 0.0360607212227569 0.941871283563497 0.477777777777778 26.1 26 1 abnormal circadian rhythm 0.0369399528226251 0.198748486740044 0.940875647957193 0.477272727272727 26.1 26 1 abnormal gametogenesis 0.0369399528226251 0.198748486740044 0.940875647957193 0.477272727272727 26.1 26 1 embryonic lethality, incomplete penetrance 0.0369399528226251 0.198748486740044 0.940875647957193 0.477272727272727 26.1 26 1 infertility 0.00183978209647097 0.0198544814098548 0.93961947219223 0.476635514018692 26.1 26 1 decreased susceptibility to hepatic steatosis 0.0149236602153082 0.103549804143875 0.938742143086542 0.476190476190476 26.1 26 1 skin edema 0.0422156624339232 0.212358868158512 0.938742143086542 0.476190476190476 26.1 26 1 increased acute inflammation 0.131477370080889 0.417155558770676 0.938742143086542 0.476190476190476 26.1 26 1 abnormal tumor vascularization 0.131477370080889 0.417155558770676 0.938742143086542 0.476190476190476 26.1 26 1 complete atrioventricular septal defect 0.131477370080889 0.417155558770676 0.938742143086542 0.476190476190476 26.1 26 1 abnormal gait 2.60557549349673e-07 9.12868878883536e-06 0.937830742947623 0.475728155339806 26.1 26 1 abnormal long bone morphology 0.0169534277813651 0.114376448743328 0.937203221540498 0.475409836065574 26.1 26 1 abnormal pulmonary alveolus morphology 0.0026510936220359 0.0269167158563849 0.936883247753697 0.475247524752475 26.1 26 1 abnormal retinal pigment epithelium morphology 0.00705226828610443 0.0597642256992597 0.936395287728825 0.475 26.1 26 1 decreased circulating phosphate level 0.0482863305157649 0.222430087329565 0.936395287728825 0.475 26.1 26 1 abnormal pancreatic beta cell morphology 0.0482863305157649 0.222430087329565 0.936395287728825 0.475 26.1 26 1 kyphoscoliosis 0.153252852543859 0.463766995988867 0.933801394965034 0.473684210526316 26.1 26 1 small superior vagus ganglion 0.153252852543859 0.463766995988867 0.933801394965034 0.473684210526316 26.1 26 1 unresponsive to tactile stimuli 0.153252852543859 0.463766995988867 0.933801394965034 0.473684210526316 26.1 26 1 altered susceptibility to infection 0.153252852543859 0.463766995988867 0.933801394965034 0.473684210526316 26.1 26 1 abnormal long term depression 0.153252852543859 0.463766995988867 0.933801394965034 0.473684210526316 26.1 26 1 delayed sexual maturation 0.153252852543859 0.463766995988867 0.933801394965034 0.473684210526316 26.1 26 1 abnormal nasal septum morphology 0.153252852543859 0.463766995988867 0.933801394965034 0.473684210526316 26.1 26 1 oliguria 0.153252852543859 0.463766995988867 0.933801394965034 0.473684210526316 26.1 26 1 increased left ventricle weight 0.153252852543859 0.463766995988867 0.933801394965034 0.473684210526316 26.1 26 1 decreased liver regeneration 0.153252852543859 0.463766995988867 0.933801394965034 0.473684210526316 26.1 26 1 decreased fertilization frequency 0.153252852543859 0.463766995988867 0.933801394965034 0.473684210526316 26.1 26 1 abnormal behavioral response to xenobiotic 0.153252852543859 0.463766995988867 0.933801394965034 0.473684210526316 26.1 26 1 shortened RR interval 0.153252852543859 0.463766995988867 0.933801394965034 0.473684210526316 26.1 26 1 thin interventricular septum 0.153252852543859 0.463766995988867 0.933801394965034 0.473684210526316 26.1 26 1 abnormal forebrain development 0.0116144777256684 0.0865458224337766 0.930919291894154 0.472222222222222 26.1 26 1 impaired wound healing 0.0633562557310039 0.278935727665261 0.930919291894154 0.472222222222222 26.1 26 1 short snout 0.00235858741024487 0.0242437445577856 0.930919291894154 0.472222222222222 26.1 26 1 distended abdomen 0.0322843932927968 0.183559836150473 0.927698117873759 0.470588235294118 26.1 26 1 abnormal dendritic spine morphology 0.0322843932927968 0.183559836150473 0.927698117873759 0.470588235294118 26.1 26 1 abnormal lung morphology 0.00164588589078894 0.0179174667542122 0.927698117873759 0.470588235294118 26.1 26 1 abnormal retinal photoreceptor morphology 0.0726925507853212 0.309363079689455 0.927698117873759 0.470588235294118 26.1 26 1 lung hemorrhage 0.0726925507853212 0.309363079689455 0.927698117873759 0.470588235294118 26.1 26 1 abnormal endoderm development 0.0726925507853212 0.309363079689455 0.927698117873759 0.470588235294118 26.1 26 1 impaired synaptic plasticity 0.0726925507853212 0.309363079689455 0.927698117873759 0.470588235294118 26.1 26 1 abnormal nervous system development 0.0726925507853212 0.309363079689455 0.927698117873759 0.470588235294118 26.1 26 1 increased incidence of corneal inflammation 0.17932181304789 0.521406206845853 0.927698117873759 0.470588235294118 26.1 26 1 absence seizures 0.17932181304789 0.521406206845853 0.927698117873759 0.470588235294118 26.1 26 1 abnormal testis development 0.17932181304789 0.521406206845853 0.927698117873759 0.470588235294118 26.1 26 1 abnormal melanosome morphology 0.17932181304789 0.521406206845853 0.927698117873759 0.470588235294118 26.1 26 1 abnormal tarsal bone morphology 0.17932181304789 0.521406206845853 0.927698117873759 0.470588235294118 26.1 26 1 decreased body fat mass 0.17932181304789 0.521406206845853 0.927698117873759 0.470588235294118 26.1 26 1 respiratory failure 0.000445400596401674 0.00629507945198389 0.926930155855652 0.470198675496689 26.1 26 1 increased total body fat amount 0.000906400280742091 0.0114160541688403 0.926832727838429 0.470149253731343 26.1 26 1 postnatal lethality 0.000247315105884166 0.00379750818448681 0.92630098215407 0.469879518072289 26.1 26 1 abnormal skeleton morphology 0.00209222803795082 0.0218214559513739 0.925681382834903 0.469565217391304 26.1 26 1 abnormal crypts of Lieberkuhn morphology 0.0835097836347951 0.34004521574434 0.924074297100814 0.46875 26.1 26 1 increased circulating glucose level 0.000804307492559072 0.0104475973250167 0.922763553416984 0.468085106382979 26.1 26 1 increased respiratory quotient 0.0419230989030844 0.211314505615851 0.922763553416984 0.468085106382979 26.1 26 1 impaired glucose tolerance 1.20014723328811e-05 0.000276422800259645 0.922087040547909 0.467741935483871 26.1 26 1 abnormal ovarian follicle morphology 0.047817355885818 0.221500321724343 0.919967300224811 0.466666666666667 26.1 26 1 lethality at weaning, complete penetrance 0.047817355885818 0.221500321724343 0.919967300224811 0.466666666666667 26.1 26 1 abnormal lactation 0.0960714019784966 0.368360047925194 0.919967300224811 0.466666666666667 26.1 26 1 abnormal cellular respiration 0.0960714019784966 0.368360047925194 0.919967300224811 0.466666666666667 26.1 26 1 vagina atresia 0.210813014489598 0.583210895107797 0.919967300224811 0.466666666666667 26.1 26 1 abnormal prostate gland morphology 0.210813014489598 0.583210895107797 0.919967300224811 0.466666666666667 26.1 26 1 abnormal pup retrieval 0.210813014489598 0.583210895107797 0.919967300224811 0.466666666666667 26.1 26 1 no suckling reflex 0.210813014489598 0.583210895107797 0.919967300224811 0.466666666666667 26.1 26 1 abnormal olfactory nerve morphology 0.210813014489598 0.583210895107797 0.919967300224811 0.466666666666667 26.1 26 1 abnormal neurotransmitter secretion 0.210813014489598 0.583210895107797 0.919967300224811 0.466666666666667 26.1 26 1 abnormal cerebral aqueduct morphology 0.210813014489598 0.583210895107797 0.919967300224811 0.466666666666667 26.1 26 1 absent chorion 0.210813014489598 0.583210895107797 0.919967300224811 0.466666666666667 26.1 26 1 liver vascular congestion 0.210813014489598 0.583210895107797 0.919967300224811 0.466666666666667 26.1 26 1 herniated liver 0.210813014489598 0.583210895107797 0.919967300224811 0.466666666666667 26.1 26 1 abnormal branching involved in lung morphogenesis 0.210813014489598 0.583210895107797 0.919967300224811 0.466666666666667 26.1 26 1 decreased brown adipose tissue mass 0.210813014489598 0.583210895107797 0.919967300224811 0.466666666666667 26.1 26 1 abnormal cardiovascular system physiology 0.00129078915818856 0.0148306606512427 0.918979150600509 0.466165413533835 26.1 26 1 hyperglycemia 0.00794525076643819 0.0650125371102467 0.918473846815355 0.465909090909091 26.1 26 1 thrombocytosis 0.0281037888649076 0.164103696717037 0.917701370913912 0.46551724137931 26.1 26 1 abnormal eye development 0.0319279997173625 0.182444204692264 0.915273589509378 0.464285714285714 26.1 26 1 reddish skin 0.110696447259334 0.368360047925194 0.915273589509378 0.464285714285714 26.1 26 1 abnormal ovulation 0.110696447259334 0.368360047925194 0.915273589509378 0.464285714285714 26.1 26 1 absent corpus callosum 0.110696447259334 0.368360047925194 0.915273589509378 0.464285714285714 26.1 26 1 prolonged QRS complex duration 0.110696447259334 0.368360047925194 0.915273589509378 0.464285714285714 26.1 26 1 microphthalmia 0.00070806329303157 0.00946939484632275 0.914813421792179 0.464052287581699 26.1 26 1 impaired limb coordination 0.0362868567037325 0.198748486740044 0.912665972445249 0.462962962962963 26.1 26 1 maternal effect 0.0215406023687684 0.130529228726703 0.912121097237819 0.462686567164179 26.1 26 1 decreased litter size 7.41000447934885e-06 0.000181599863471727 0.912016388123224 0.462633451957295 26.1 26 1 increased urine protein level 0.0146439053342299 0.101750599214796 0.90985776945311 0.461538461538462 26.1 26 1 abnormal snout morphology 0.041257962503936 0.208172782410833 0.90985776945311 0.461538461538462 26.1 26 1 absent corpus luteum 0.041257962503936 0.208172782410833 0.90985776945311 0.461538461538462 26.1 26 1 abnormal response to injury 0.071260989399919 0.305887335862465 0.90985776945311 0.461538461538462 26.1 26 1 abnormal Schwann cell morphology 0.127774301658293 0.406443191016629 0.90985776945311 0.461538461538462 26.1 26 1 abnormal erythrocyte osmotic lysis 0.127774301658293 0.406443191016629 0.90985776945311 0.461538461538462 26.1 26 1 absent teeth 0.249297339167008 0.634415908489318 0.90985776945311 0.461538461538462 26.1 26 1 absent common myeloid progenitor cells 0.249297339167008 0.634415908489318 0.90985776945311 0.461538461538462 26.1 26 1 pup cannibalization 0.249297339167008 0.634415908489318 0.90985776945311 0.461538461538462 26.1 26 1 abnormal digestion 0.249297339167008 0.634415908489318 0.90985776945311 0.461538461538462 26.1 26 1 abnormal pulmonary alveolus epithelial cell morphology 0.249297339167008 0.634415908489318 0.90985776945311 0.461538461538462 26.1 26 1 abnormal bile duct development 0.249297339167008 0.634415908489318 0.90985776945311 0.461538461538462 26.1 26 1 tracheoesophageal fistula 0.249297339167008 0.634415908489318 0.90985776945311 0.461538461538462 26.1 26 1 muscle fatigue 0.249297339167008 0.634415908489318 0.90985776945311 0.461538461538462 26.1 26 1 small otic vesicle 0.249297339167008 0.634415908489318 0.90985776945311 0.461538461538462 26.1 26 1 increased circulating ammonia level 0.249297339167008 0.634415908489318 0.90985776945311 0.461538461538462 26.1 26 1 abnormal hair follicle inner root sheath morphology 0.249297339167008 0.634415908489318 0.90985776945311 0.461538461538462 26.1 26 1 decreased cardiac stroke volume 0.249297339167008 0.634415908489318 0.90985776945311 0.461538461538462 26.1 26 1 postnatal lethality, incomplete penetrance 3.65954931975752e-10 2.39556024549917e-08 0.909323815363055 0.461267605633803 26.1 26 1 abnormal lens morphology 0.00230705739224338 0.0237631687917408 0.908673058815801 0.4609375 26.1 26 1 kidney cysts 0.0187186760790674 0.120472721207452 0.90575931103215 0.459459459459459 26.1 26 1 abnormal long bone metaphysis morphology 0.0815303261722192 0.335217663394042 0.90575931103215 0.459459459459459 26.1 26 1 decreased circulating chloride level 0.0815303261722192 0.335217663394042 0.90575931103215 0.459459459459459 26.1 26 1 improved glucose tolerance 0.000237724652224599 0.0036729197044018 0.905215637976308 0.459183673469388 26.1 26 1 abnormal renal glomerulus morphology 0.00533995807145264 0.0473552431470176 0.904292890129238 0.458715596330275 26.1 26 1 decreased body height 0.147784521599009 0.457210194856958 0.903539312720796 0.458333333333333 26.1 26 1 abnormal body weight 0.147784521599009 0.457210194856958 0.903539312720796 0.458333333333333 26.1 26 1 increased stereotypic behavior 0.147784521599009 0.457210194856958 0.903539312720796 0.458333333333333 26.1 26 1 abnormal vasodilation 0.147784521599009 0.457210194856958 0.903539312720796 0.458333333333333 26.1 26 1 abnormal impulse conducting system conduction 0.147784521599009 0.457210194856958 0.903539312720796 0.458333333333333 26.1 26 1 hypopigmentation 0.147784521599009 0.457210194856958 0.903539312720796 0.458333333333333 26.1 26 1 decreased triglyceride level 0.0933674096800683 0.365462520187521 0.90119245736308 0.457142857142857 26.1 26 1 respiratory distress 0.000674385980570944 0.00904875622448025 0.900215731433857 0.456647398843931 26.1 26 1 delayed wound healing 0.0608107138812008 0.26915774160051 0.899968011089489 0.456521739130435 26.1 26 1 reduced long term potentiation 0.00590041141371642 0.0516805401113366 0.897672174326506 0.455357142857143 26.1 26 1 increased sensitivity to xenobiotic induced morbidity/mortality 0.00663447260366441 0.0571046733619904 0.896072045673517 0.454545454545455 26.1 26 1 abnormal contextual conditioning behavior 0.0457622313585141 0.218715396794513 0.896072045673517 0.454545454545455 26.1 26 1 abnormal learning/memory/conditioning 0.0457622313585141 0.218715396794513 0.896072045673517 0.454545454545455 26.1 26 1 increased circulating cholesterol level 0.000742565989867969 0.00990419785413712 0.896072045673517 0.454545454545455 26.1 26 1 hypertension 0.0692753407125061 0.299380243675225 0.896072045673517 0.454545454545455 26.1 26 1 intracerebral hemorrhage 0.171324032071064 0.510381472786553 0.896072045673517 0.454545454545455 26.1 26 1 testis hypoplasia 0.171324032071064 0.510381472786553 0.896072045673517 0.454545454545455 26.1 26 1 aphakia 0.171324032071064 0.510381472786553 0.896072045673517 0.454545454545455 26.1 26 1 abnormal retinal outer plexiform layer morphology 0.171324032071064 0.510381472786553 0.896072045673517 0.454545454545455 26.1 26 1 abnormal temporal bone morphology 0.171324032071064 0.510381472786553 0.896072045673517 0.454545454545455 26.1 26 1 pulmonary vascular congestion 0.171324032071064 0.510381472786553 0.896072045673517 0.454545454545455 26.1 26 1 rough coat 0.171324032071064 0.510381472786553 0.896072045673517 0.454545454545455 26.1 26 1 premature suture closure 0.297056335622631 0.636139182829203 0.896072045673517 0.454545454545455 26.1 26 1 abnormal stomach epithelium morphology 0.297056335622631 0.636139182829203 0.896072045673517 0.454545454545455 26.1 26 1 abnormal eye distance/ position 0.297056335622631 0.636139182829203 0.896072045673517 0.454545454545455 26.1 26 1 failure of somite differentiation 0.297056335622631 0.636139182829203 0.896072045673517 0.454545454545455 26.1 26 1 secondary sex reversal 0.297056335622631 0.636139182829203 0.896072045673517 0.454545454545455 26.1 26 1 abnormal larynx morphology 0.297056335622631 0.636139182829203 0.896072045673517 0.454545454545455 26.1 26 1 abnormal bronchiole morphology 0.297056335622631 0.636139182829203 0.896072045673517 0.454545454545455 26.1 26 1 abnormal vestibular ganglion morphology 0.297056335622631 0.636139182829203 0.896072045673517 0.454545454545455 26.1 26 1 fatigue 0.297056335622631 0.636139182829203 0.896072045673517 0.454545454545455 26.1 26 1 impaired luteinization 0.297056335622631 0.636139182829203 0.896072045673517 0.454545454545455 26.1 26 1 abnormal radial glial cell morphology 0.297056335622631 0.636139182829203 0.896072045673517 0.454545454545455 26.1 26 1 pathological neovascularization 0.297056335622631 0.636139182829203 0.896072045673517 0.454545454545455 26.1 26 1 abnormal coronal suture morphology 0.297056335622631 0.636139182829203 0.896072045673517 0.454545454545455 26.1 26 1 enlarged placenta 0.297056335622631 0.636139182829203 0.896072045673517 0.454545454545455 26.1 26 1 cyclopia 0.297056335622631 0.636139182829203 0.896072045673517 0.454545454545455 26.1 26 1 increased circulating triiodothyronine level 0.297056335622631 0.636139182829203 0.896072045673517 0.454545454545455 26.1 26 1 abnormal superovulation 0.297056335622631 0.636139182829203 0.896072045673517 0.454545454545455 26.1 26 1 decreased palatine bone horizontal plate size 0.297056335622631 0.636139182829203 0.896072045673517 0.454545454545455 26.1 26 1 chylous ascites 0.297056335622631 0.636139182829203 0.896072045673517 0.454545454545455 26.1 26 1 abnormal motor coordination/ balance 0.00964970943129882 0.073743939202322 0.896072045673517 0.454545454545455 26.1 26 1 belly spot 0.107033142195798 0.368360047925194 0.896072045673517 0.454545454545455 26.1 26 1 dextrocardia 0.107033142195798 0.368360047925194 0.896072045673517 0.454545454545455 26.1 26 1 abnormal epidermis stratum basale morphology 0.107033142195798 0.368360047925194 0.896072045673517 0.454545454545455 26.1 26 1 abnormal neurocranium morphology 0.0233804933136914 0.140480621057506 0.893682520218388 0.453333333333333 26.1 26 1 decreased eosinophil cell number 0.0346675454362698 0.194224142506129 0.893271820530787 0.453125 26.1 26 1 abnormal coat/ hair morphology 0.0519363753924721 0.237266728721349 0.892690641727579 0.452830188679245 26.1 26 1 alopecia 0.0122255171958363 0.0903684275895394 0.892299110744366 0.452631578947368 26.1 26 1 neonatal lethality, complete penetrance 1.84558184268806e-07 6.95588611164629e-06 0.890569848901838 0.451754385964912 26.1 26 1 absent mature ovarian follicles 0.122837608632304 0.395545050450299 0.89029093570143 0.451612903225806 26.1 26 1 decreased susceptibility to bacterial infection induced morbidity/mortality 0.122837608632304 0.395545050450299 0.89029093570143 0.451612903225806 26.1 26 1 impaired balance 0.0106003255531509 0.0802688274382433 0.889044029629019 0.450980392156863 26.1 26 1 abnormal gluconeogenesis 0.0589617418875762 0.264265464766389 0.889044029629019 0.450980392156863 26.1 26 1 abnormal dopamine level 0.199145241321768 0.567763653625098 0.887111325216782 0.45 26.1 26 1 abnormal hair texture 0.199145241321768 0.567763653625098 0.887111325216782 0.45 26.1 26 1 decreased paired-pulse facilitation 0.199145241321768 0.567763653625098 0.887111325216782 0.45 26.1 26 1 absent placental labyrinth 0.199145241321768 0.567763653625098 0.887111325216782 0.45 26.1 26 1 abnormal postnatal subventricular zone morphology 0.199145241321768 0.567763653625098 0.887111325216782 0.45 26.1 26 1 dilated vasculature 0.199145241321768 0.567763653625098 0.887111325216782 0.45 26.1 26 1 enhanced behavioral response to xenobiotic 0.199145241321768 0.567763653625098 0.887111325216782 0.45 26.1 26 1 decreased muscle cell glucose uptake 0.199145241321768 0.567763653625098 0.887111325216782 0.45 26.1 26 1 decreased heart rate 0.0119162999353702 0.0886152349453911 0.887111325216782 0.45 26.1 26 1 increased startle reflex 0.0174306772706031 0.116243457669236 0.88600382044123 0.449438202247191 26.1 26 1 abnormal excitatory postsynaptic currents 0.0256451189082093 0.151862891514971 0.884583942523857 0.448717948717949 26.1 26 1 abnormal heart ventricle morphology 0.0256451189082093 0.151862891514971 0.884583942523857 0.448717948717949 26.1 26 1 absent gastric milk in neonates 0.0256451189082093 0.151862891514971 0.884583942523857 0.448717948717949 26.1 26 1 increased blood urea nitrogen level 0.00331102608001195 0.0321725678673037 0.883712431250434 0.448275862068966 26.1 26 1 short limbs 0.0196169774333691 0.12609103712017 0.883712431250434 0.448275862068966 26.1 26 1 cochlear ganglion degeneration 0.0502711307913453 0.230931556497639 0.883712431250434 0.448275862068966 26.1 26 1 glomerulosclerosis 0.0502711307913453 0.230931556497639 0.883712431250434 0.448275862068966 26.1 26 1 abnormal parietal bone morphology 0.141151007793738 0.441096899355432 0.883712431250434 0.448275862068966 26.1 26 1 abnormal circulating glucose level 0.141151007793738 0.441096899355432 0.883712431250434 0.448275862068966 26.1 26 1 decreased bone strength 0.141151007793738 0.441096899355432 0.883712431250434 0.448275862068966 26.1 26 1 cyanosis 0.00084973695703207 0.0109803671720378 0.883004328340778 0.447916666666667 26.1 26 1 hepatic necrosis 0.0760660952096794 0.322341417093829 0.880819755534394 0.446808510638298 26.1 26 1 short mandible 0.0569188697787978 0.25556983497249 0.880070759143633 0.446428571428571 26.1 26 1 abnormal lipid level 0.0248429776815624 0.148194021541694 0.87879836768463 0.44578313253012 26.1 26 1 increased sensitivity to induced morbidity/mortality 0.00132261231623266 0.0150571997099713 0.878540201301644 0.445652173913043 26.1 26 1 cochlear outer hair cell degeneration 0.0367217280385017 0.198748486740044 0.876159333547439 0.444444444444444 26.1 26 1 increased circulating corticosterone level 0.0864417285738565 0.348781508235958 0.876159333547439 0.444444444444444 26.1 26 1 abnormal metabolism 0.0864417285738565 0.348781508235958 0.876159333547439 0.444444444444444 26.1 26 1 cardiomyopathy 0.0864417285738565 0.348781508235958 0.876159333547439 0.444444444444444 26.1 26 1 narrow eye opening 0.11737633283932 0.37894046455264 0.876159333547439 0.444444444444444 26.1 26 1 lowered ear position 0.232210812126392 0.615148450654313 0.876159333547439 0.444444444444444 26.1 26 1 abnormal heart shape 0.232210812126392 0.615148450654313 0.876159333547439 0.444444444444444 26.1 26 1 abnormal phrenic nerve morphology 0.232210812126392 0.615148450654313 0.876159333547439 0.444444444444444 26.1 26 1 abnormal iron level 0.232210812126392 0.615148450654313 0.876159333547439 0.444444444444444 26.1 26 1 abnormal thyroid cartilage morphology 0.232210812126392 0.615148450654313 0.876159333547439 0.444444444444444 26.1 26 1 abnormal white adipose tissue morphology 0.232210812126392 0.615148450654313 0.876159333547439 0.444444444444444 26.1 26 1 abnormal metacarpal bone morphology 0.232210812126392 0.615148450654313 0.876159333547439 0.444444444444444 26.1 26 1 increased circulating renin level 0.232210812126392 0.615148450654313 0.876159333547439 0.444444444444444 26.1 26 1 abnormal body wall morphology 0.232210812126392 0.615148450654313 0.876159333547439 0.444444444444444 26.1 26 1 atrioventricular block 0.232210812126392 0.615148450654313 0.876159333547439 0.444444444444444 26.1 26 1 abnormal macrophage chemotaxis 0.232210812126392 0.615148450654313 0.876159333547439 0.444444444444444 26.1 26 1 abnormal neuronal precursor proliferation 0.0644559903434635 0.282776500845442 0.876159333547439 0.444444444444444 26.1 26 1 abnormal type II pneumocyte morphology 0.162417511147311 0.487644609509881 0.876159333547439 0.444444444444444 26.1 26 1 abnormal maternal nurturing 0.0547681950836138 0.246812359151007 0.872568516606671 0.442622950819672 26.1 26 1 decreased body temperature 0.0730026703642565 0.31041733765998 0.87194702905923 0.442307692307692 26.1 26 1 impaired righting response 0.0206424926535109 0.126158229015468 0.871547968634031 0.442105263157895 26.1 26 1 kidney failure 0.0982675293711301 0.368360047925194 0.871065383933791 0.441860465116279 26.1 26 1 polyuria 0.0353870351715594 0.19670446924973 0.870469987225702 0.441558441558442 26.1 26 1 short maxilla 0.134144135414595 0.421051781506378 0.869716985506649 0.441176470588235 26.1 26 1 overexpanded pulmonary alveoli 0.134144135414595 0.421051781506378 0.869716985506649 0.441176470588235 26.1 26 1 increased width of hypertrophic chondrocyte zone 0.134144135414595 0.421051781506378 0.869716985506649 0.441176470588235 26.1 26 1 decreased osteoblast cell number 0.134144135414595 0.421051781506378 0.869716985506649 0.441176470588235 26.1 26 1 abnormal skin physiology 0.134144135414595 0.421051781506378 0.869716985506649 0.441176470588235 26.1 26 1 decreased exploration in new environment 0.0303016999960683 0.174278563561202 0.868336482355051 0.44047619047619 26.1 26 1 increased body length 0.0826953070708387 0.338887275681567 0.867397740211965 0.44 26.1 26 1 short stride length 0.0826953070708387 0.338887275681567 0.867397740211965 0.44 26.1 26 1 kidney inflammation 0.0826953070708387 0.338887275681567 0.867397740211965 0.44 26.1 26 1 decreased oocyte number 0.0826953070708387 0.338887275681567 0.867397740211965 0.44 26.1 26 1 abnormal nest building behavior 0.1871729741818 0.538257541360956 0.867397740211965 0.44 26.1 26 1 increased thermal nociceptive threshold 0.0259820827105998 0.152430261185417 0.866531209002962 0.43956043956044 26.1 26 1 abnormal excitatory postsynaptic potential 0.0340342055330166 0.190890837121485 0.865474463626129 0.439024390243902 26.1 26 1 scaly skin 0.111751919805261 0.368360047925194 0.865474463626129 0.439024390243902 26.1 26 1 cardiac hypertrophy 0.0223050759516308 0.134833235552082 0.864983831844028 0.438775510204082 26.1 26 1 abnormal retina morphology 0.00135947009775032 0.0153712812188815 0.863642771639618 0.438095238095238 26.1 26 1 curly tail 0.093688608352913 0.366431467418036 0.86246934396076 0.4375 26.1 26 1 increased dopamine level 0.1534259169637 0.464008472276234 0.86246934396076 0.4375 26.1 26 1 abnormal tympanic ring morphology 0.271774630068808 0.636139182829203 0.86246934396076 0.4375 26.1 26 1 absent mandible 0.271774630068808 0.636139182829203 0.86246934396076 0.4375 26.1 26 1 paternal imprinting 0.271774630068808 0.636139182829203 0.86246934396076 0.4375 26.1 26 1 increased pancreatic beta cell number 0.271774630068808 0.636139182829203 0.86246934396076 0.4375 26.1 26 1 abnormal molar crown morphology 0.271774630068808 0.636139182829203 0.86246934396076 0.4375 26.1 26 1 abnormal amnion morphology 0.271774630068808 0.636139182829203 0.86246934396076 0.4375 26.1 26 1 abnormal level of surface class II molecules 0.271774630068808 0.636139182829203 0.86246934396076 0.4375 26.1 26 1 decreased creatinine clearance 0.271774630068808 0.636139182829203 0.86246934396076 0.4375 26.1 26 1 abnormal thoracic cage shape 0.271774630068808 0.636139182829203 0.86246934396076 0.4375 26.1 26 1 abnormal pulmonary alveolus wall morphology 0.271774630068808 0.636139182829203 0.86246934396076 0.4375 26.1 26 1 decreased adipocyte glucose uptake 0.271774630068808 0.636139182829203 0.86246934396076 0.4375 26.1 26 1 increased vascular permeability 0.127133930760412 0.404924011224745 0.859310115594604 0.435897435897436 26.1 26 1 abnormal circulating hormone level 0.127133930760412 0.404924011224745 0.859310115594604 0.435897435897436 26.1 26 1 decreased trabecular bone volume 0.127133930760412 0.404924011224745 0.859310115594604 0.435897435897436 26.1 26 1 abnormal epidermal layer morphology 0.0566340176497892 0.254520540025024 0.857112391513799 0.434782608695652 26.1 26 1 hyperkeratosis 0.0566340176497892 0.254520540025024 0.857112391513799 0.434782608695652 26.1 26 1 hypotension 0.216067738029682 0.585477667046661 0.857112391513799 0.434782608695652 26.1 26 1 abnormal postnatal growth 0.216067738029682 0.585477667046661 0.857112391513799 0.434782608695652 26.1 26 1 abnormal sacral vertebrae morphology 0.216067738029682 0.585477667046661 0.857112391513799 0.434782608695652 26.1 26 1 increased susceptibility to fungal infection 0.216067738029682 0.585477667046661 0.857112391513799 0.434782608695652 26.1 26 1 abnormal palatal shelf fusion at midline 0.216067738029682 0.585477667046661 0.857112391513799 0.434782608695652 26.1 26 1 short tail 0.0410742949511517 0.207667294087378 0.85504706044991 0.433734939759036 26.1 26 1 increased body weight 0.00161085252432701 0.0175745423432606 0.853668636369324 0.433035714285714 26.1 26 1 decreased compact bone thickness 0.0636763453186842 0.279602663689721 0.853274574835379 0.432835820895522 26.1 26 1 decreased cardiac muscle contractility 0.0257260213657484 0.151862891514971 0.85299165886229 0.432692307692308 26.1 26 1 increased brown adipose tissue amount 0.144687576014253 0.451298238665147 0.85247935155967 0.432432432432432 26.1 26 1 abnormal suckling behavior 0.0392706366344129 0.20393676122777 0.851268443389841 0.431818181818182 26.1 26 1 increased liver weight 0.0392706366344129 0.20393676122777 0.851268443389841 0.431818181818182 26.1 26 1 abnormal amino acid level 0.120301592751684 0.388033961501813 0.851268443389841 0.431818181818182 26.1 26 1 increased circulating insulin level 0.00776161408211584 0.0637195215487233 0.850148353332749 0.43125 26.1 26 1 decreased monocyte cell number 0.0715809324196674 0.306995809299867 0.849200584822903 0.430769230769231 26.1 26 1 abnormal neuromuscular synapse morphology 0.0606758351939532 0.269067554150285 0.848779354374082 0.430555555555556 26.1 26 1 skin lesions 0.0804495188341493 0.331321486920441 0.844867928777888 0.428571428571429 26.1 26 1 organ of Corti degeneration 0.113735877998168 0.368360047925194 0.844867928777888 0.428571428571429 26.1 26 1 abnormal artery morphology 0.16472667971549 0.493089790363756 0.844867928777888 0.428571428571429 26.1 26 1 abnormal intestinal goblet cell morphology 0.16472667971549 0.493089790363756 0.844867928777888 0.428571428571429 26.1 26 1 impaired adaptive thermogenesis 0.16472667971549 0.493089790363756 0.844867928777888 0.428571428571429 26.1 26 1 abnormal circulating cholesterol level 0.201208309063294 0.572988745042865 0.844867928777888 0.428571428571429 26.1 26 1 abnormal interparietal bone morphology 0.319505368674618 0.636139182829203 0.844867928777888 0.428571428571429 26.1 26 1 abnormal vasoconstriction 0.319505368674618 0.636139182829203 0.844867928777888 0.428571428571429 26.1 26 1 megacephaly 0.319505368674618 0.636139182829203 0.844867928777888 0.428571428571429 26.1 26 1 abnormal adrenal gland secretion 0.319505368674618 0.636139182829203 0.844867928777888 0.428571428571429 26.1 26 1 decreased coping response 0.319505368674618 0.636139182829203 0.844867928777888 0.428571428571429 26.1 26 1 abnormal iris pigmentation 0.319505368674618 0.636139182829203 0.844867928777888 0.428571428571429 26.1 26 1 premature hair loss 0.319505368674618 0.636139182829203 0.844867928777888 0.428571428571429 26.1 26 1 increased lung compliance 0.319505368674618 0.636139182829203 0.844867928777888 0.428571428571429 26.1 26 1 pulmonary alveolar hemorrhage 0.319505368674618 0.636139182829203 0.844867928777888 0.428571428571429 26.1 26 1 abnormal respiratory motile cilium physiology 0.319505368674618 0.636139182829203 0.844867928777888 0.428571428571429 26.1 26 1 decreased inflammatory response 0.0491537411674642 0.226216338860439 0.844867928777888 0.428571428571429 26.1 26 1 abnormal optic nerve morphology 0.136343905991099 0.427147942258008 0.844867928777888 0.428571428571429 26.1 26 1 abnormal muscle morphology 0.136343905991099 0.427147942258008 0.844867928777888 0.428571428571429 26.1 26 1 small ears 0.249896144752428 0.634415908489318 0.844867928777888 0.428571428571429 26.1 26 1 abnormal scapula morphology 0.249896144752428 0.634415908489318 0.844867928777888 0.428571428571429 26.1 26 1 trunk curl 0.249896144752428 0.634415908489318 0.844867928777888 0.428571428571429 26.1 26 1 increased vasoconstriction 0.249896144752428 0.634415908489318 0.844867928777888 0.428571428571429 26.1 26 1 decreased cochlear outer hair cell number 0.249896144752428 0.634415908489318 0.844867928777888 0.428571428571429 26.1 26 1 abnormal clavicle morphology 0.249896144752428 0.634415908489318 0.844867928777888 0.428571428571429 26.1 26 1 increased bone ossification 0.249896144752428 0.634415908489318 0.844867928777888 0.428571428571429 26.1 26 1 abnormal chondrocyte morphology 0.107477452696841 0.368360047925194 0.839652694649629 0.425925925925926 26.1 26 1 abnormal long bone epiphyseal plate proliferative zone 0.107477452696841 0.368360047925194 0.839652694649629 0.425925925925926 26.1 26 1 impaired ovarian folliculogenesis 0.154537556156211 0.466802879099666 0.837827362704739 0.425 26.1 26 1 perinatal lethality 0.154537556156211 0.466802879099666 0.837827362704739 0.425 26.1 26 1 abnormal tail morphology 0.0855897527920952 0.346345952298784 0.836333909295283 0.424242424242424 26.1 26 1 absent vibrissae 0.18761006679268 0.538891502478975 0.836333909295283 0.424242424242424 26.1 26 1 decreased systemic arterial blood pressure 0.18761006679268 0.538891502478975 0.836333909295283 0.424242424242424 26.1 26 1 circling 0.0583460553808463 0.261741772335176 0.834928306086383 0.423529411764706 26.1 26 1 abnormal spatial learning 0.0126748720124894 0.0903684275895394 0.834501451124171 0.423312883435583 26.1 26 1 abnormal xiphoid process morphology 0.230732000699039 0.614832192542966 0.834036288665351 0.423076923076923 26.1 26 1 abnormal kidney cortex morphology 0.230732000699039 0.614832192542966 0.834036288665351 0.423076923076923 26.1 26 1 small seminal vesicle 0.230732000699039 0.614832192542966 0.834036288665351 0.423076923076923 26.1 26 1 thick skin 0.230732000699039 0.614832192542966 0.834036288665351 0.423076923076923 26.1 26 1 no spontaneous movement 0.230732000699039 0.614832192542966 0.834036288665351 0.423076923076923 26.1 26 1 altered response to myocardial infarction 0.145045339650866 0.451847567165347 0.832351366870067 0.422222222222222 26.1 26 1 small placenta 0.145045339650866 0.451847567165347 0.832351366870067 0.422222222222222 26.1 26 1 abnormal circulating amino acid level 0.114025019860261 0.368360047925194 0.830045684413363 0.421052631578947 26.1 26 1 increased grooming behavior 0.175166497562565 0.520102519056731 0.830045684413363 0.421052631578947 26.1 26 1 abnormal neurotransmitter level 0.28963478273187 0.636139182829203 0.830045684413363 0.421052631578947 26.1 26 1 decreased germ cell number 0.28963478273187 0.636139182829203 0.830045684413363 0.421052631578947 26.1 26 1 abnormal metatarsal bone morphology 0.28963478273187 0.636139182829203 0.830045684413363 0.421052631578947 26.1 26 1 eyelids fail to open 0.28963478273187 0.636139182829203 0.830045684413363 0.421052631578947 26.1 26 1 decreased liver glycogen level 0.28963478273187 0.636139182829203 0.830045684413363 0.421052631578947 26.1 26 1 small kidney 0.0617088844124768 0.272648046138608 0.828866642248003 0.420454545454545 26.1 26 1 short femur 0.0617088844124768 0.272648046138608 0.828866642248003 0.420454545454545 26.1 26 1 abnormal cranial ganglia morphology 0.213746897853279 0.583210895107797 0.826698726008471 0.419354838709677 26.1 26 1 abnormal intestine morphology 0.0856292505180914 0.346345952298784 0.825839371823431 0.418918918918919 26.1 26 1 abnormal intestinal mucosa morphology 0.163758897157477 0.491079272669347 0.82521983741096 0.418604651162791 26.1 26 1 abnormal blood circulation 0.163758897157477 0.491079272669347 0.82521983741096 0.418604651162791 26.1 26 1 increased anxiety-related response 0.0283257151258287 0.16495674712909 0.822581244805329 0.41726618705036 26.1 26 1 abnormal systemic arterial blood pressure 0.198548356055611 0.567763653625098 0.821399375200724 0.416666666666667 26.1 26 1 abnormal nervous system electrophysiology 0.0764835525346105 0.323834616050797 0.821399375200724 0.416666666666667 26.1 26 1 abnormal eye physiology 0.120349025647698 0.388033961501813 0.821399375200724 0.416666666666667 26.1 26 1 decreased metastatic potential 0.264841464051592 0.634415908489318 0.821399375200724 0.416666666666667 26.1 26 1 abnormal nursing 0.264841464051592 0.634415908489318 0.821399375200724 0.416666666666667 26.1 26 1 abnormal cardiac muscle contractility 0.264841464051592 0.634415908489318 0.821399375200724 0.416666666666667 26.1 26 1 abnormal mineral level 0.377681738241265 0.696429446905224 0.821399375200724 0.416666666666667 26.1 26 1 abnormal esophagus morphology 0.377681738241265 0.696429446905224 0.821399375200724 0.416666666666667 26.1 26 1 amyloidosis 0.377681738241265 0.696429446905224 0.821399375200724 0.416666666666667 26.1 26 1 mesocardia 0.377681738241265 0.696429446905224 0.821399375200724 0.416666666666667 26.1 26 1 abnormal superior cervical ganglion morphology 0.377681738241265 0.696429446905224 0.821399375200724 0.416666666666667 26.1 26 1 abnormal corticospinal tract morphology 0.377681738241265 0.696429446905224 0.821399375200724 0.416666666666667 26.1 26 1 abnormal aorta elastic fiber morphology 0.377681738241265 0.696429446905224 0.821399375200724 0.416666666666667 26.1 26 1 dilated bile duct 0.377681738241265 0.696429446905224 0.821399375200724 0.416666666666667 26.1 26 1 increased fear-related response 0.377681738241265 0.696429446905224 0.821399375200724 0.416666666666667 26.1 26 1 delayed somite formation 0.377681738241265 0.696429446905224 0.821399375200724 0.416666666666667 26.1 26 1 decreased cochlear nerve compound action potential 0.377681738241265 0.696429446905224 0.821399375200724 0.416666666666667 26.1 26 1 abnormal palatine bone morphology 0.377681738241265 0.696429446905224 0.821399375200724 0.416666666666667 26.1 26 1 abnormal somatic nervous system physiology 0.377681738241265 0.696429446905224 0.821399375200724 0.416666666666667 26.1 26 1 decreased renal glomerular filtration rate 0.377681738241265 0.696429446905224 0.821399375200724 0.416666666666667 26.1 26 1 decreased prostaglandin level 0.377681738241265 0.696429446905224 0.821399375200724 0.416666666666667 26.1 26 1 abnormal aorta elastic tissue morphology 0.377681738241265 0.696429446905224 0.821399375200724 0.416666666666667 26.1 26 1 abnormal colon goblet cell morphology 0.377681738241265 0.696429446905224 0.821399375200724 0.416666666666667 26.1 26 1 obese 0.0901530005640426 0.359718304536979 0.819265870330073 0.415584415584416 26.1 26 1 abnormal pancreatic islet morphology 0.143620431132239 0.448250718245226 0.818299754916948 0.415094339622642 26.1 26 1 abnormal response/metabolism to endogenous compounds 0.0850823128687291 0.344694223552058 0.817392548980233 0.414634146341463 26.1 26 1 abnormal enzyme/coenzyme level 0.134705440657102 0.422547015932585 0.815734551923478 0.413793103448276 26.1 26 1 abnormal middle ear morphology 0.243601698194745 0.634415908489318 0.815734551923478 0.413793103448276 26.1 26 1 aphagia 0.243601698194745 0.634415908489318 0.815734551923478 0.413793103448276 26.1 26 1 stomach inflammation 0.243601698194745 0.634415908489318 0.815734551923478 0.413793103448276 26.1 26 1 absent long term depression 0.243601698194745 0.634415908489318 0.815734551923478 0.413793103448276 26.1 26 1 increased retinal apoptosis 0.243601698194745 0.634415908489318 0.815734551923478 0.413793103448276 26.1 26 1 abnormal blood homeostasis 0.05477001899552 0.246812359151007 0.812753065988085 0.412280701754386 26.1 26 1 cochlear inner hair cell degeneration 0.161072949312245 0.483899711852909 0.811735853139539 0.411764705882353 26.1 26 1 cardiac fibrosis 0.0891798005422448 0.359537688571854 0.811735853139539 0.411764705882353 26.1 26 1 abnormal vision 0.225036218757341 0.601911391568693 0.811735853139539 0.411764705882353 26.1 26 1 hydroureter 0.336491601983451 0.636139182829203 0.811735853139539 0.411764705882353 26.1 26 1 abnormal vagus nerve morphology 0.336491601983451 0.636139182829203 0.811735853139539 0.411764705882353 26.1 26 1 aminoaciduria 0.336491601983451 0.636139182829203 0.811735853139539 0.411764705882353 26.1 26 1 coloboma 0.336491601983451 0.636139182829203 0.811735853139539 0.411764705882353 26.1 26 1 common atrium 0.336491601983451 0.636139182829203 0.811735853139539 0.411764705882353 26.1 26 1 decreased sensitivity to induced morbidity/mortality 0.193844723284563 0.555837174836139 0.806464841106165 0.409090909090909 26.1 26 1 abnormal basisphenoid bone morphology 0.304292222762603 0.636139182829203 0.806464841106165 0.409090909090909 26.1 26 1 increased coping response 0.304292222762603 0.636139182829203 0.806464841106165 0.409090909090909 26.1 26 1 abnormal channel response 0.304292222762603 0.636139182829203 0.806464841106165 0.409090909090909 26.1 26 1 abnormal blood-brain barrier function 0.304292222762603 0.636139182829203 0.806464841106165 0.409090909090909 26.1 26 1 abnormal long bone hypertrophic chondrocyte zone 0.180545613601394 0.524351679898971 0.804636122645607 0.408163265306122 26.1 26 1 abnormal epidermis stratum corneum morphology 0.180545613601394 0.524351679898971 0.804636122645607 0.408163265306122 26.1 26 1 abnormal osteoblast physiology 0.168468728806575 0.503987928931276 0.803146055751819 0.407407407407407 26.1 26 1 rectal prolapse 0.277698212265851 0.636139182829203 0.803146055751819 0.407407407407407 26.1 26 1 abnormal brain commissure morphology 0.277698212265851 0.636139182829203 0.803146055751819 0.407407407407407 26.1 26 1 decreased susceptibility to pharmacologically induced seizures 0.277698212265851 0.636139182829203 0.803146055751819 0.407407407407407 26.1 26 1 abnormal tooth morphology 0.147346085469817 0.457210194856958 0.800864390820706 0.40625 26.1 26 1 abnormal lumbar vertebrae morphology 0.255019147935623 0.634415908489318 0.800864390820706 0.40625 26.1 26 1 abnormal auditory brainstem response waveform shape 0.255019147935623 0.634415908489318 0.800864390820706 0.40625 26.1 26 1 abnormal humerus morphology 0.235271615174718 0.622593768879907 0.799199392087191 0.405405405405405 26.1 26 1 abnormal vibrissa morphology 0.217824145526117 0.588028058828542 0.79793082162356 0.404761904761905 26.1 26 1 abnormal tibia morphology 0.202242251742413 0.575274558272443 0.796932159769213 0.404255319148936 26.1 26 1 pulmonary hypoplasia 0.202242251742413 0.575274558272443 0.796932159769213 0.404255319148936 26.1 26 1 abnormal CNS synaptic transmission 0.0951655889714667 0.368360047925194 0.796508485043126 0.404040404040404 26.1 26 1 decreased kidney weight 0.188211340383546 0.540306646513641 0.796125548271471 0.403846153846154 26.1 26 1 abnormal trabecular bone morphology 0.0751973009601196 0.318931434165895 0.795169815320365 0.403361344537815 26.1 26 1 abnormal heart left ventricle morphology 0.14356720443508 0.448250718245226 0.794019396027367 0.402777777777778 26.1 26 1 increased circulating calcium level 0.195449910394338 0.560117110721101 0.788543400192695 0.4 26.1 26 1 abnormal social investigation 0.139552147256426 0.436923809062756 0.788543400192695 0.4 26.1 26 1 impaired fertilization 0.159040638266966 0.478082885424866 0.788543400192695 0.4 26.1 26 1 increased circulating chloride level 0.210100334130581 0.583210895107797 0.788543400192695 0.4 26.1 26 1 decreased osteoclast cell number 0.226377645707028 0.604848972820871 0.788543400192695 0.4 26.1 26 1 increased susceptibility to weight loss 0.244609057691035 0.634415908489318 0.788543400192695 0.4 26.1 26 1 abnormal heart tube morphology 0.288920398634704 0.636139182829203 0.788543400192695 0.4 26.1 26 1 abnormal synaptic transmission 0.288920398634704 0.636139182829203 0.788543400192695 0.4 26.1 26 1 abnormal microglial cell physiology 0.288920398634704 0.636139182829203 0.788543400192695 0.4 26.1 26 1 decreased acute inflammation 0.31662045729812 0.636139182829203 0.788543400192695 0.4 26.1 26 1 waved hair 0.349961143671938 0.659991163672438 0.788543400192695 0.4 26.1 26 1 increased urine glucose level 0.349961143671938 0.659991163672438 0.788543400192695 0.4 26.1 26 1 kidney atrophy 0.349961143671938 0.659991163672438 0.788543400192695 0.4 26.1 26 1 abnormal circulating cytokine level 0.349961143671938 0.659991163672438 0.788543400192695 0.4 26.1 26 1 abnormal apical ectodermal ridge morphology 0.391966938131298 0.718774610100703 0.788543400192695 0.4 26.1 26 1 placental labyrinth hypoplasia 0.391966938131298 0.718774610100703 0.788543400192695 0.4 26.1 26 1 abnormal respiratory system morphology 0.391966938131298 0.718774610100703 0.788543400192695 0.4 26.1 26 1 dilated ureter 0.391966938131298 0.718774610100703 0.788543400192695 0.4 26.1 26 1 decreased aggression towards males 0.391966938131298 0.718774610100703 0.788543400192695 0.4 26.1 26 1 abnormal energy homeostasis 0.391966938131298 0.718774610100703 0.788543400192695 0.4 26.1 26 1 abnormal Muller cell morphology 0.391966938131298 0.718774610100703 0.788543400192695 0.4 26.1 26 1 lactation failure 0.391966938131298 0.718774610100703 0.788543400192695 0.4 26.1 26 1 abnormal coronary vessel morphology 0.391966938131298 0.718774610100703 0.788543400192695 0.4 26.1 26 1 decreased susceptibility to injury 0.176021339647019 0.520102519056731 0.782745286955984 0.397058823529412 26.1 26 1 abnormal hair follicle morphology 0.188546787986383 0.540957479949396 0.782285119238785 0.396825396825397 26.1 26 1 increased susceptibility to pharmacologically induced seizures 0.131267123193266 0.417155558770676 0.780329406440688 0.395833333333333 26.1 26 1 abnormal cardiovascular system morphology 0.234323370418355 0.620414458664883 0.780329406440688 0.395833333333333 26.1 26 1 abnormal frontal bone morphology 0.274470604921775 0.636139182829203 0.778167829137528 0.394736842105263 26.1 26 1 decreased threshold for auditory brainstem response 0.274470604921775 0.636139182829203 0.778167829137528 0.394736842105263 26.1 26 1 atelectasis 0.181707810328757 0.527419111076759 0.777437155119559 0.394366197183099 26.1 26 1 diarrhea 0.298835050678535 0.636139182829203 0.776595772917048 0.393939393939394 26.1 26 1 cardiovascular system phenotype 0.298835050678535 0.636139182829203 0.776595772917048 0.393939393939394 26.1 26 1 shortened head 0.327191679043976 0.636139182829203 0.774462268046397 0.392857142857143 26.1 26 1 abnormal respiration 0.327191679043976 0.636139182829203 0.774462268046397 0.392857142857143 26.1 26 1 abnormal retinal inner nuclear layer morphology 0.327191679043976 0.636139182829203 0.774462268046397 0.392857142857143 26.1 26 1 decreased circulating progesterone level 0.327191679043976 0.636139182829203 0.774462268046397 0.392857142857143 26.1 26 1 increased kidney weight 0.241730904981121 0.634415908489318 0.773081764894799 0.392156862745098 26.1 26 1 abnormal coat appearance 0.200426692510205 0.571089802541965 0.771401152362419 0.391304347826087 26.1 26 1 abnormal cochlear ganglion morphology 0.361007962948052 0.670655196290724 0.771401152362419 0.391304347826087 26.1 26 1 abnormal corneal stroma morphology 0.361007962948052 0.670655196290724 0.771401152362419 0.391304347826087 26.1 26 1 abnormal basicranium morphology 0.361007962948052 0.670655196290724 0.771401152362419 0.391304347826087 26.1 26 1 short humerus 0.282858663527559 0.636139182829203 0.769310634334337 0.390243902439024 26.1 26 1 abnormal cholesterol homeostasis 0.282858663527559 0.636139182829203 0.769310634334337 0.390243902439024 26.1 26 1 abnormal digit morphology 0.205979104988369 0.583210895107797 0.766639416854009 0.388888888888889 26.1 26 1 head tilt 0.307684355795005 0.636139182829203 0.766639416854009 0.388888888888889 26.1 26 1 delayed kidney development 0.402852104619762 0.723686697079019 0.766639416854009 0.388888888888889 26.1 26 1 right pulmonary isomerism 0.402852104619762 0.723686697079019 0.766639416854009 0.388888888888889 26.1 26 1 abnormal mammary gland morphology 0.402852104619762 0.723686697079019 0.766639416854009 0.388888888888889 26.1 26 1 absent spleen 0.402852104619762 0.723686697079019 0.766639416854009 0.388888888888889 26.1 26 1 decreased heart rate variability 0.402852104619762 0.723686697079019 0.766639416854009 0.388888888888889 26.1 26 1 abnormal eye anterior chamber morphology 0.402852104619762 0.723686697079019 0.766639416854009 0.388888888888889 26.1 26 1 decreased pulmonary respiratory rate 0.402852104619762 0.723686697079019 0.766639416854009 0.388888888888889 26.1 26 1 abnormal sperm axoneme morphology 0.402852104619762 0.723686697079019 0.766639416854009 0.388888888888889 26.1 26 1 abnormal mandible morphology 0.248659376435351 0.634415908489318 0.766639416854009 0.388888888888889 26.1 26 1 abnormal eye electrophysiology 0.133175091725254 0.419332962869076 0.765734293575551 0.388429752066116 26.1 26 1 decreased urine osmolality 0.26838261640243 0.636139182829203 0.764404316513327 0.387755102040816 26.1 26 1 eyelids open at birth 0.275180632854606 0.636139182829203 0.758214807877591 0.384615384615385 26.1 26 1 small lens 0.315651947324694 0.636139182829203 0.758214807877591 0.384615384615385 26.1 26 1 abnormal renal/urinary system morphology 0.457921987662676 0.776734363662398 0.758214807877591 0.384615384615385 26.1 26 1 abnormal lung interstitium morphology 0.457921987662676 0.776734363662398 0.758214807877591 0.384615384615385 26.1 26 1 increased synaptic depression 0.457921987662676 0.776734363662398 0.758214807877591 0.384615384615385 26.1 26 1 abnormal soleus morphology 0.457921987662676 0.776734363662398 0.758214807877591 0.384615384615385 26.1 26 1 anal atresia 0.457921987662676 0.776734363662398 0.758214807877591 0.384615384615385 26.1 26 1 absent lateral semicircular canal 0.457921987662676 0.776734363662398 0.758214807877591 0.384615384615385 26.1 26 1 abnormal dopaminergic neuron morphology 0.457921987662676 0.776734363662398 0.758214807877591 0.384615384615385 26.1 26 1 abnormal insulin secretion 0.457921987662676 0.776734363662398 0.758214807877591 0.384615384615385 26.1 26 1 small interparietal bone 0.457921987662676 0.776734363662398 0.758214807877591 0.384615384615385 26.1 26 1 increased cochlear inner hair cell number 0.457921987662676 0.776734363662398 0.758214807877591 0.384615384615385 26.1 26 1 increased circulating thyroid-stimulating hormone level 0.457921987662676 0.776734363662398 0.758214807877591 0.384615384615385 26.1 26 1 small pituitary gland 0.457921987662676 0.776734363662398 0.758214807877591 0.384615384615385 26.1 26 1 increased prostaglandin level 0.457921987662676 0.776734363662398 0.758214807877591 0.384615384615385 26.1 26 1 abnormal gut flora balance 0.457921987662676 0.776734363662398 0.758214807877591 0.384615384615385 26.1 26 1 thin skin 0.344520041867847 0.650716479989574 0.753754720772429 0.382352941176471 26.1 26 1 increased food intake 0.225999006995107 0.604161773133078 0.750993714469233 0.380952380952381 26.1 26 1 abnormal anxiety-related response 0.411539604545483 0.723686697079019 0.750993714469233 0.380952380952381 26.1 26 1 dry skin 0.411539604545483 0.723686697079019 0.750993714469233 0.380952380952381 26.1 26 1 decreased vocalization 0.411539604545483 0.723686697079019 0.750993714469233 0.380952380952381 26.1 26 1 decreased retinal photoreceptor cell number 0.378274445118506 0.697005690542432 0.747756672596521 0.379310344827586 26.1 26 1 enlarged epididymis 0.378274445118506 0.697005690542432 0.747756672596521 0.379310344827586 26.1 26 1 impaired swimming 0.272494464922433 0.636139182829203 0.746726704727931 0.378787878787879 26.1 26 1 increased white adipose tissue amount 0.351761676172571 0.662884219302478 0.745919432614711 0.378378378378378 26.1 26 1 abnormal breathing pattern 0.351761676172571 0.662884219302478 0.745919432614711 0.378378378378378 26.1 26 1 abnormal food intake 0.277661007224049 0.636139182829203 0.742830739311959 0.376811594202899 26.1 26 1 head bobbing 0.35827768110489 0.666329519064234 0.739259437680652 0.375 26.1 26 1 abnormal skin pigmentation 0.35827768110489 0.666329519064234 0.739259437680652 0.375 26.1 26 1 abnormal digestive system morphology 0.418707862285928 0.732186859357641 0.739259437680652 0.375 26.1 26 1 abnormal foregut morphology 0.418707862285928 0.732186859357641 0.739259437680652 0.375 26.1 26 1 abnormal startle reflex 0.418707862285928 0.732186859357641 0.739259437680652 0.375 26.1 26 1 abnormal retinal ganglion layer morphology 0.418707862285928 0.732186859357641 0.739259437680652 0.375 26.1 26 1 abnormal lymphatic vessel morphology 0.385225949843803 0.708764460234069 0.739259437680651 0.375 26.1 26 1 abnormal serotonin level 0.385225949843803 0.708764460234069 0.739259437680651 0.375 26.1 26 1 abnormal intestinal absorption 0.464082322968791 0.784775512158306 0.739259437680651 0.375 26.1 26 1 abnormal extraembryonic endoderm formation 0.464082322968791 0.784775512158306 0.739259437680651 0.375 26.1 26 1 decreased aggression towards mice 0.464082322968791 0.784775512158306 0.739259437680651 0.375 26.1 26 1 small pancreas 0.464082322968791 0.784775512158306 0.739259437680651 0.375 26.1 26 1 small epididymis 0.464082322968791 0.784775512158306 0.739259437680651 0.375 26.1 26 1 loose skin 0.464082322968791 0.784775512158306 0.739259437680651 0.375 26.1 26 1 decreased circulating triiodothyronine level 0.464082322968791 0.784775512158306 0.739259437680651 0.375 26.1 26 1 impaired behavioral response to addictive substance 0.464082322968791 0.784775512158306 0.739259437680651 0.375 26.1 26 1 dilated respiratory conducting tubes 0.464082322968791 0.784775512158306 0.739259437680651 0.375 26.1 26 1 abnormal limb morphology 0.287232877667285 0.636139182829203 0.735973840179849 0.373333333333333 26.1 26 1 abnormal femur morphology 0.303250972810926 0.636139182829203 0.735581530030499 0.373134328358209 26.1 26 1 cryptorchism 0.424772819382367 0.742270732851167 0.730132777956199 0.37037037037037 26.1 26 1 abnormal palate morphology 0.424772819382367 0.742270732851167 0.730132777956199 0.37037037037037 26.1 26 1 abnormal inner ear morphology 0.369582131561505 0.686071307656152 0.728545532786729 0.369565217391304 26.1 26 1 abnormal forelimb morphology 0.369582131561505 0.686071307656152 0.728545532786729 0.369565217391304 26.1 26 1 abnormal reproductive system physiology 0.396848134402202 0.723686697079019 0.726289973861693 0.368421052631579 26.1 26 1 abnormal retinal outer nuclear layer morphology 0.396848134402202 0.723686697079019 0.726289973861693 0.368421052631579 26.1 26 1 abnormal compact bone morphology 0.396848134402202 0.723686697079019 0.726289973861693 0.368421052631579 26.1 26 1 hyporesponsive to tactile stimuli 0.396848134402202 0.723686697079019 0.726289973861693 0.368421052631579 26.1 26 1 abnormal triglyceride level 0.468895542387698 0.791032663065039 0.726289973861693 0.368421052631579 26.1 26 1 thin dermal layer 0.468895542387698 0.791032663065039 0.726289973861693 0.368421052631579 26.1 26 1 abnormal ear morphology 0.468895542387698 0.791032663065039 0.726289973861693 0.368421052631579 26.1 26 1 abnormal neural crest cell migration 0.468895542387698 0.791032663065039 0.726289973861693 0.368421052631579 26.1 26 1 abnormal cochlear inner hair cell morphology 0.468895542387698 0.791032663065039 0.726289973861693 0.368421052631579 26.1 26 1 increased circulating VLDL cholesterol level 0.468895542387698 0.791032663065039 0.726289973861693 0.368421052631579 26.1 26 1 right-sided stomach 0.468895542387698 0.791032663065039 0.726289973861693 0.368421052631579 26.1 26 1 increased fluid intake 0.374537751479981 0.695011306830624 0.724172510381047 0.36734693877551 26.1 26 1 decreased food intake 0.320652528187295 0.636139182829203 0.723663247012283 0.367088607594937 26.1 26 1 abnormal kidney development 0.355677152114563 0.665563437070906 0.722831450176637 0.366666666666667 26.1 26 1 abnormal hair cycle 0.430005735188075 0.750887515816312 0.722831450176637 0.366666666666667 26.1 26 1 delayed eyelid opening 0.430005735188075 0.750887515816312 0.722831450176637 0.366666666666667 26.1 26 1 corneal opacity 0.33920012202375 0.640911738347192 0.721905929753876 0.366197183098592 26.1 26 1 increased susceptibility to injury 0.37911353167721 0.698293158124442 0.720304067483712 0.365384615384615 26.1 26 1 abnormal photoreceptor outer segment morphology 0.406276255793849 0.723686697079019 0.716857636538814 0.363636363636364 26.1 26 1 decreased cardiac output 0.472823822707128 0.796849091452562 0.716857636538814 0.363636363636364 26.1 26 1 abnormal basement membrane morphology 0.472823822707128 0.796849091452562 0.716857636538814 0.363636363636364 26.1 26 1 decreased susceptibility to viral infection induced morbidity/mortality 0.472823822707128 0.796849091452562 0.716857636538814 0.363636363636364 26.1 26 1 deafness 0.31792016393181 0.636139182829203 0.716857636538814 0.363636363636364 26.1 26 1 abnormal aorta morphology 0.434592177938241 0.751342297180848 0.716857636538814 0.363636363636364 26.1 26 1 dilated heart atrium 0.434592177938241 0.751342297180848 0.716857636538814 0.363636363636364 26.1 26 1 head tossing 0.434592177938241 0.751342297180848 0.716857636538814 0.363636363636364 26.1 26 1 increased systemic arterial blood pressure 0.410380502633353 0.723686697079019 0.713044564004033 0.361702127659574 26.1 26 1 abnormal epidermis stratum granulosum morphology 0.438664032483443 0.753835427152031 0.711879458507294 0.361111111111111 26.1 26 1 renal hypoplasia 0.438664032483443 0.753835427152031 0.711879458507294 0.361111111111111 26.1 26 1 short radius 0.438664032483443 0.753835427152031 0.711879458507294 0.361111111111111 26.1 26 1 abnormal axon extension 0.414156728129477 0.725248054362601 0.709689060173426 0.36 26.1 26 1 abnormal keratinocyte physiology 0.476132027591569 0.801881122974968 0.709689060173426 0.36 26.1 26 1 decreased placenta weight 0.476132027591569 0.801881122974968 0.709689060173426 0.36 26.1 26 1 abnormal stria vascularis morphology 0.478984564014807 0.805050069585697 0.704056607314906 0.357142857142857 26.1 26 1 myoclonus 0.478984564014807 0.805050069585697 0.704056607314906 0.357142857142857 26.1 26 1 abnormal jaw morphology 0.478984564014807 0.805050069585697 0.704056607314906 0.357142857142857 26.1 26 1 increased circulating luteinizing hormone level 0.478984564014807 0.805050069585697 0.704056607314906 0.357142857142857 26.1 26 1 abnormal hormone level 0.478984564014807 0.805050069585697 0.704056607314906 0.357142857142857 26.1 26 1 midline facial cleft 0.534820109322709 0.825728906493119 0.704056607314906 0.357142857142857 26.1 26 1 absent atrioventricular cushions 0.534820109322709 0.825728906493119 0.704056607314906 0.357142857142857 26.1 26 1 abnormal fluid regulation 0.534820109322709 0.825728906493119 0.704056607314906 0.357142857142857 26.1 26 1 amyloid beta deposits 0.534820109322709 0.825728906493119 0.704056607314906 0.357142857142857 26.1 26 1 abnormal uterus development 0.534820109322709 0.825728906493119 0.704056607314906 0.357142857142857 26.1 26 1 abnormal imprinting 0.534820109322709 0.825728906493119 0.704056607314906 0.357142857142857 26.1 26 1 abnormal hair cuticle 0.534820109322709 0.825728906493119 0.704056607314906 0.357142857142857 26.1 26 1 increased circulating growth hormone level 0.534820109322709 0.825728906493119 0.704056607314906 0.357142857142857 26.1 26 1 sternebra fusion 0.534820109322709 0.825728906493119 0.704056607314906 0.357142857142857 26.1 26 1 decreased compact bone area 0.534820109322709 0.825728906493119 0.704056607314906 0.357142857142857 26.1 26 1 hydronephrosis 0.383735032558714 0.706543962612732 0.704056607314906 0.357142857142857 26.1 26 1 abnormal body temperature homeostasis 0.481489770020987 0.808441311459471 0.699514306622552 0.354838709677419 26.1 26 1 abnormal retinal photoreceptor layer morphology 0.481489770020987 0.808441311459471 0.699514306622552 0.354838709677419 26.1 26 1 abnormal podocyte morphology 0.481489770020987 0.808441311459471 0.699514306622552 0.354838709677419 26.1 26 1 abnormal phalanx morphology 0.451420978633676 0.769379708359896 0.698189468920616 0.354166666666667 26.1 26 1 abnormal inhibitory postsynaptic currents 0.431945240066205 0.751342297180848 0.695773588405319 0.352941176470588 26.1 26 1 abnormal bone remodeling 0.483722433976638 0.811642195289637 0.695773588405319 0.352941176470588 26.1 26 1 increased susceptibility to weight gain 0.483722433976638 0.811642195289637 0.695773588405319 0.352941176470588 26.1 26 1 abnormal dorsal-ventral axis patterning 0.533677261688068 0.825728906493119 0.695773588405319 0.352941176470588 26.1 26 1 abnormal duodenum morphology 0.533677261688068 0.825728906493119 0.695773588405319 0.352941176470588 26.1 26 1 decreased growth hormone level 0.533677261688068 0.825728906493119 0.695773588405319 0.352941176470588 26.1 26 1 abnormal pancreatic beta cell physiology 0.485736142151832 0.814746226299854 0.692639473142232 0.351351351351351 26.1 26 1 abnormal basioccipital bone morphology 0.532937141696185 0.825728906493119 0.689975475168608 0.35 26.1 26 1 abnormal hearing physiology 0.532937141696185 0.825728906493119 0.689975475168608 0.35 26.1 26 1 abnormal neuron differentiation 0.431689717114065 0.751342297180848 0.686455192132034 0.348214285714286 26.1 26 1 abnormal hepatocyte physiology 0.532458947911969 0.825728906493119 0.685689913211039 0.347826086956522 26.1 26 1 abnormal hair growth 0.493622986569138 0.825728906493119 0.682393327089832 0.346153846153846 26.1 26 1 focal hair loss 0.531989889749702 0.825728906493119 0.679778793269565 0.344827586206897 26.1 26 1 abnormal urine homeostasis 0.478806865431337 0.805050069585697 0.677654484540597 0.34375 26.1 26 1 abnormal long term potentiation 0.531913675828084 0.825728906493119 0.677654484540597 0.34375 26.1 26 1 abnormal diaphragm morphology 0.531913675828084 0.825728906493119 0.677654484540597 0.34375 26.1 26 1 abnormal action potential 0.500356417517638 0.825728906493119 0.67589434302231 0.342857142857143 26.1 26 1 impaired branching involved in ureteric bud morphogenesis 0.531957906181641 0.825728906493119 0.674412118585858 0.342105263157895 26.1 26 1 abnormal innervation 0.532328419961914 0.825728906493119 0.671100766121443 0.340425531914894 26.1 26 1 abnormal hindlimb morphology 0.532502887113719 0.825728906493119 0.670261890163791 0.34 26.1 26 1 abnormal colon morphology 0.533119987912304 0.825728906493119 0.668257118807369 0.338983050847458 26.1 26 1 abnormal hair shaft morphology 0.572782140626034 0.844323303589487 0.657119500160579 0.333333333333333 26.1 26 1 abnormal autopod morphology 0.573940277196806 0.845779881236407 0.657119500160579 0.333333333333333 26.1 26 1 abnormal iris morphology 0.576777859689659 0.84920682212372 0.657119500160579 0.333333333333333 26.1 26 1 acanthosis 0.576777859689659 0.84920682212372 0.657119500160579 0.333333333333333 26.1 26 1 abnormal lens fiber morphology 0.576777859689659 0.84920682212372 0.657119500160579 0.333333333333333 26.1 26 1 heart right ventricle hypertrophy 0.57853072712986 0.851283752579429 0.657119500160579 0.333333333333333 26.1 26 1 abnormal limb bone morphology 0.57853072712986 0.851283752579429 0.657119500160579 0.333333333333333 26.1 26 1 apnea 0.58933449072499 0.864878788010862 0.657119500160579 0.333333333333333 26.1 26 1 decreased ovulation rate 0.58933449072499 0.864878788010862 0.657119500160579 0.333333333333333 26.1 26 1 decreased fatty acid level 0.58933449072499 0.864878788010862 0.657119500160579 0.333333333333333 26.1 26 1 abnormal lung saccule morphology 0.58933449072499 0.864878788010862 0.657119500160579 0.333333333333333 26.1 26 1 abnormal stomach glandular epithelium morphology 0.599089840222221 0.877641918464532 0.657119500160579 0.333333333333333 26.1 26 1 thick dermal layer 0.599089840222221 0.877641918464532 0.657119500160579 0.333333333333333 26.1 26 1 absent ureter 0.599089840222221 0.877641918464532 0.657119500160579 0.333333333333333 26.1 26 1 decreased fluid intake 0.599089840222221 0.877641918464532 0.657119500160579 0.333333333333333 26.1 26 1 polyphagia 0.570858950889562 0.841737783247057 0.657119500160579 0.333333333333333 26.1 26 1 abnormal middle ear ossicle morphology 0.580574424773005 0.854038368789385 0.657119500160579 0.333333333333333 26.1 26 1 emphysema 0.582981967030516 0.85707307505225 0.657119500160579 0.333333333333333 26.1 26 1 enhanced paired-pulse facilitation 0.582981967030516 0.85707307505225 0.657119500160579 0.333333333333333 26.1 26 1 abnormal trigeminal nerve morphology 0.585854122661278 0.860786845906632 0.657119500160579 0.333333333333333 26.1 26 1 abnormal bone trabecula morphology 0.585854122661278 0.860786845906632 0.657119500160579 0.333333333333333 26.1 26 1 hypoalgesia 0.593635910271536 0.870677669104037 0.657119500160579 0.333333333333333 26.1 26 1 abnormal bile salt homeostasis 0.593635910271536 0.870677669104037 0.657119500160579 0.333333333333333 26.1 26 1 absent incisors 0.606246694918414 0.885778944851427 0.657119500160579 0.333333333333333 26.1 26 1 hyperpigmentation 0.606246694918414 0.885778944851427 0.657119500160579 0.333333333333333 26.1 26 1 abnormal bronchus morphology 0.606246694918414 0.885778944851427 0.657119500160579 0.333333333333333 26.1 26 1 increased alcohol consumption 0.606246694918414 0.885778944851427 0.657119500160579 0.333333333333333 26.1 26 1 abnormal secondary palate development 0.606246694918414 0.885778944851427 0.657119500160579 0.333333333333333 26.1 26 1 abnormal aorta wall morphology 0.606246694918414 0.885778944851427 0.657119500160579 0.333333333333333 26.1 26 1 ostium primum atrial septal defect 0.606246694918414 0.885778944851427 0.657119500160579 0.333333333333333 26.1 26 1 abnormal microglial cell activation 0.606246694918414 0.885778944851427 0.657119500160579 0.333333333333333 26.1 26 1 dehydration 0.600542479789018 0.879510991154066 0.647732078729714 0.328571428571429 26.1 26 1 absent kidney 0.611820660658498 0.893398235038459 0.643708898116486 0.326530612244898 26.1 26 1 abnormal respiratory system physiology 0.611820660658498 0.893398235038459 0.643708898116486 0.326530612244898 26.1 26 1 abnormal organ of Corti morphology 0.616781656988871 0.89617077789709 0.641837651319636 0.325581395348837 26.1 26 1 increased insulin secretion 0.623072127919313 0.904782205603789 0.639359513669753 0.324324324324324 26.1 26 1 abnormal hair follicle development 0.623072127919313 0.904782205603789 0.639359513669753 0.324324324324324 26.1 26 1 syndactyly 0.640743965581724 0.924239266097153 0.634844262867 0.322033898305085 26.1 26 1 diaphragmatic hernia 0.642606238081893 0.92585173311828 0.630834720154156 0.32 26.1 26 1 abnormal energy expenditure 0.642606238081893 0.92585173311828 0.630834720154156 0.32 26.1 26 1 impaired conditioned place preference behavior 0.642606238081893 0.92585173311828 0.630834720154156 0.32 26.1 26 1 abnormal stomach mucosa morphology 0.642606238081893 0.92585173311828 0.630834720154156 0.32 26.1 26 1 increased body size 0.65001488446826 0.927039198880587 0.627250431971462 0.318181818181818 26.1 26 1 abnormal circulating lipid level 0.65001488446826 0.927039198880587 0.627250431971462 0.318181818181818 26.1 26 1 irregular coat pigmentation 0.659179516145847 0.931652867279997 0.622534263310022 0.315789473684211 26.1 26 1 abnormal nail morphology 0.659179516145847 0.931652867279997 0.622534263310022 0.315789473684211 26.1 26 1 flaky skin 0.659179516145847 0.931652867279997 0.622534263310022 0.315789473684211 26.1 26 1 osteoarthritis 0.659179516145847 0.931652867279997 0.622534263310022 0.315789473684211 26.1 26 1 delayed hair appearance 0.670866863986425 0.945753088221157 0.616049531400543 0.3125 26.1 26 1 abnormal pituitary gland morphology 0.670866863986425 0.945753088221157 0.616049531400543 0.3125 26.1 26 1 white spotting 0.670866863986425 0.945753088221157 0.616049531400543 0.3125 26.1 26 1 impaired muscle relaxation 0.670866863986425 0.945753088221157 0.616049531400543 0.3125 26.1 26 1 bowed tibia 0.670866863986425 0.945753088221157 0.616049531400543 0.3125 26.1 26 1 bowed radius 0.670866863986425 0.945753088221157 0.616049531400543 0.3125 26.1 26 1 abnormal epididymis epithelium morphology 0.670866863986425 0.945753088221157 0.616049531400543 0.3125 26.1 26 1 abnormal wound healing 0.670866863986425 0.945753088221157 0.616049531400543 0.3125 26.1 26 1 decreased skeletal muscle weight 0.670866863986425 0.945753088221157 0.616049531400543 0.3125 26.1 26 1 abnormal stomach morphology 0.691693297273117 0.949123850780171 0.606571846302073 0.307692307692308 26.1 26 1 abnormal ocular fundus morphology 0.691693297273117 0.949123850780171 0.606571846302073 0.307692307692308 26.1 26 1 abnormal retinal cone cell morphology 0.701445606711637 0.949123850780171 0.599978674059659 0.304347826086957 26.1 26 1 abnormal innervation pattern to muscle 0.701445606711637 0.949123850780171 0.599978674059659 0.304347826086957 26.1 26 1 blistering 0.701445606711637 0.949123850780171 0.599978674059659 0.304347826086957 26.1 26 1 decreased epididymis weight 0.701445606711637 0.949123850780171 0.599978674059659 0.304347826086957 26.1 26 1 single kidney 0.718195942532414 0.960232414431271 0.597381363782345 0.303030303030303 26.1 26 1 decreased sensitivity to xenobiotic induced morbidity/mortality 0.718195942532414 0.960232414431271 0.597381363782345 0.303030303030303 26.1 26 1 abnormal lens epithelium morphology 0.713283390909988 0.954177163156007 0.591407550144521 0.3 26.1 26 1 abnormal heart right ventricle morphology 0.713283390909988 0.954177163156007 0.591407550144521 0.3 26.1 26 1 abnormal incus morphology 0.713283390909988 0.954177163156007 0.591407550144521 0.3 26.1 26 1 decreased circulating VLDL cholesterol level 0.713283390909988 0.954177163156007 0.591407550144521 0.3 26.1 26 1 nuclear cataracts 0.713283390909988 0.954177163156007 0.591407550144521 0.3 26.1 26 1 abnormal heart electrocardiography waveform feature 0.713283390909988 0.954177163156007 0.591407550144521 0.3 26.1 26 1 wrinkled skin 0.736257160267575 0.982795645916605 0.584106222364959 0.296296296296296 26.1 26 1 distended urinary bladder 0.728029198277407 0.972073339084836 0.579811323671099 0.294117647058824 26.1 26 1 increased aggression towards mice 0.728029198277407 0.972073339084836 0.579811323671099 0.294117647058824 26.1 26 1 abnormal heart rate 0.728029198277407 0.972073339084836 0.579811323671099 0.294117647058824 26.1 26 1 nephrocalcinosis 0.728029198277407 0.972073339084836 0.579811323671099 0.294117647058824 26.1 26 1 abnormal electroretinogram waveform feature 0.728029198277407 0.972073339084836 0.579811323671099 0.294117647058824 26.1 26 1 decreased pancreatic beta cell number 0.756238026041588 0.9984830625151 0.579811323671099 0.294117647058824 26.1 26 1 short ulna 0.77387412004426 1 0.576982975750752 0.292682926829268 26.1 26 1 decreased neuronal precursor cell number 0.765543277080476 1 0.572329887236633 0.290322580645161 26.1 26 1 abnormal cartilage development 0.796485971487426 1 0.569503566805835 0.288888888888889 26.1 26 1 increased percent body fat/body weight 0.809859296869063 1 0.568661105908194 0.288461538461538 26.1 26 1 abnormal stapes morphology 0.761142383165369 1 0.563245285851925 0.285714285714286 26.1 26 1 abnormal inner ear vestibule morphology 0.788443417707071 1 0.551980380134886 0.28 26.1 26 1 abnormal retinal rod cell morphology 0.777621259067862 1 0.547599583467149 0.277777777777778 26.1 26 1 acidosis 0.777621259067862 1 0.547599583467149 0.277777777777778 26.1 26 1 abnormal anterior eye segment morphology 0.777621259067862 1 0.547599583467149 0.277777777777778 26.1 26 1 abnormal spinal nerve morphology 0.811473736277727 1 0.543823034615652 0.275862068965517 26.1 26 1 intestinal ulcer 0.802815195176784 1 0.53764322740411 0.272727272727273 26.1 26 1 decreased airway responsiveness 0.802815195176784 1 0.53764322740411 0.272727272727273 26.1 26 1 abnormal tracheal cartilage morphology 0.802815195176784 1 0.53764322740411 0.272727272727273 26.1 26 1 abnormal cochlear sensory epithelium morphology 0.802815195176784 1 0.53764322740411 0.272727272727273 26.1 26 1 abnormal estrous cycle 0.842346809203852 1 0.525695600128463 0.266666666666667 26.1 26 1 abnormal pain threshold 0.842346809203852 1 0.525695600128463 0.266666666666667 26.1 26 1 maternal imprinting 0.819921881540011 1 0.518778552758352 0.263157894736842 26.1 26 1 abnormal photoreceptor inner segment morphology 0.819921881540011 1 0.518778552758352 0.263157894736842 26.1 26 1 fragile skeleton 0.838592696988013 1 0.514267434908279 0.260869565217391 26.1 26 1 increased susceptibility to age related obesity 0.838592696988013 1 0.514267434908279 0.260869565217391 26.1 26 1 abnormal digestive system physiology 0.904885562475767 1 0.512553210125252 0.26 26.1 26 1 abnormal cochlea morphology 0.913538868880039 1 0.511092944569339 0.259259259259259 26.1 26 1 abnormal single cell response 0.854829062447783 1 0.511092944569339 0.259259259259259 26.1 26 1 abnormal intestine physiology 0.869061081246765 1 0.508737677543674 0.258064516129032 26.1 26 1 abnormal axon guidance 0.902669169820826 1 0.504301011751142 0.255813953488372 26.1 26 1 abnormal malleus morphology 0.868920593513344 1 0.492839625120434 0.25 26.1 26 1 abnormal sensory capabilities/reflexes/nociception 0.868920593513344 1 0.492839625120434 0.25 26.1 26 1 abnormal embryonic/fetal subventricular zone morphology 0.884944814432721 1 0.469371071543271 0.238095238095238 26.1 26 1 abnormal ureter morphology 0.915408310380363 1 0.454928884726555 0.230769230769231 26.1 26 1 abnormal tectorial membrane morphology 0.915408310380363 1 0.454928884726555 0.230769230769231 26.1 26 1 abnormal feces composition 0.956933735973234 1 0.394271700096348 0.2 26.1 26 1 impaired behavioral response to xenobiotic 0.975089956536155 1 0.394271700096348 0.2 26.1 26 1 abnormal reflex 0.980480266089482 1 0.383319708427005 0.194444444444444 26.1 26 1 neonatal lethality 1.35973018653543e-07 1.93275933657536e-06 0.638523956723339 1 26.3 26 3 abnormal diaphragm morphology 1.35973018653543e-07 1.93275933657536e-06 0.638523956723339 1 26.3 26 3 abnormal tympanic ring morphology 0.000369635736318078 0.00227591310418618 0.638523956723339 1 26.3 26 3 failure of tooth eruption 0.000369635736318078 0.00227591310418618 0.638523956723339 1 26.3 26 3 vasculature congestion 0.000369635736318078 0.00227591310418618 0.638523956723339 1 26.3 26 3 disorganized retinal layers 0.000369635736318078 0.00227591310418618 0.638523956723339 1 26.3 26 3 disorganized yolk sac vascular plexus 0.000369635736318078 0.00227591310418618 0.638523956723339 1 26.3 26 3 intraventricular hemorrhage 0.000369635736318078 0.00227591310418618 0.638523956723339 1 26.3 26 3 impaired muscle relaxation 0.000369635736318078 0.00227591310418618 0.638523956723339 1 26.3 26 3 decreased aggression towards mice 0.000369635736318078 0.00227591310418618 0.638523956723339 1 26.3 26 3 increased cochlear outer hair cell number 0.000369635736318078 0.00227591310418618 0.638523956723339 1 26.3 26 3 dystonia 0.000369635736318078 0.00227591310418618 0.638523956723339 1 26.3 26 3 kidney degeneration 0.000369635736318078 0.00227591310418618 0.638523956723339 1 26.3 26 3 impaired behavioral response to addictive substance 0.000369635736318078 0.00227591310418618 0.638523956723339 1 26.3 26 3 impaired somite development 0.000369635736318078 0.00227591310418618 0.638523956723339 1 26.3 26 3 increased heart left ventricle size 0.000369635736318078 0.00227591310418618 0.638523956723339 1 26.3 26 3 abnormal exoccipital bone morphology 0.0192375033581862 0.0631309889228076 0.638523956723339 1 26.3 26 3 failure of vascular branching 0.0192375033581862 0.0631309889228076 0.638523956723339 1 26.3 26 3 schistocytosis 0.0192375033581862 0.0631309889228076 0.638523956723339 1 26.3 26 3 clubfoot 0.0192375033581862 0.0631309889228076 0.638523956723339 1 26.3 26 3 absent mammary gland 0.0192375033581862 0.0631309889228076 0.638523956723339 1 26.3 26 3 abnormal vagus ganglion morphology 0.0192375033581862 0.0631309889228076 0.638523956723339 1 26.3 26 3 increased sensitivity to skin irradiation 0.0192375033581862 0.0631309889228076 0.638523956723339 1 26.3 26 3 dry eyes 0.0192375033581862 0.0631309889228076 0.638523956723339 1 26.3 26 3 absent eyelids 0.0192375033581862 0.0631309889228076 0.638523956723339 1 26.3 26 3 unidirectional circling 0.0192375033581862 0.0631309889228076 0.638523956723339 1 26.3 26 3 abnormal erythrocyte cell number 0.0192375033581862 0.0631309889228076 0.638523956723339 1 26.3 26 3 abnormal urination 0.0192375033581862 0.0631309889228076 0.638523956723339 1 26.3 26 3 abnormal pulmonary circulation 0.0192375033581862 0.0631309889228076 0.638523956723339 1 26.3 26 3 short ureter 0.0192375033581862 0.0631309889228076 0.638523956723339 1 26.3 26 3 decreased aerobic running capacity 0.0192375033581862 0.0631309889228076 0.638523956723339 1 26.3 26 3 altered response to CNS ischemic injury 0.0192375033581862 0.0631309889228076 0.638523956723339 1 26.3 26 3 hypospadia 0.0192375033581862 0.0631309889228076 0.638523956723339 1 26.3 26 3 absent tympanic ring 0.0192375033581862 0.0631309889228076 0.638523956723339 1 26.3 26 3 early eyelid opening 0.0192375033581862 0.0631309889228076 0.638523956723339 1 26.3 26 3 calcified muscle 0.0192375033581862 0.0631309889228076 0.638523956723339 1 26.3 26 3 loss of GABAergic neurons 0.0192375033581862 0.0631309889228076 0.638523956723339 1 26.3 26 3 abnormal perineum morphology 0.0192375033581862 0.0631309889228076 0.638523956723339 1 26.3 26 3 increased cardiac output 0.0192375033581862 0.0631309889228076 0.638523956723339 1 26.3 26 3 abnormal ovary development 0.0192375033581862 0.0631309889228076 0.638523956723339 1 26.3 26 3 abnormal eyelid aperture 0.0192375033581862 0.0631309889228076 0.638523956723339 1 26.3 26 3 elevated level of mitotic sister chromatid exchange 0.0192375033581862 0.0631309889228076 0.638523956723339 1 26.3 26 3 binucleate 0.0192375033581862 0.0631309889228076 0.638523956723339 1 26.3 26 3 increased left ventricle systolic pressure 0.0192375033581862 0.0631309889228076 0.638523956723339 1 26.3 26 3 abnormal forelimb zeugopod morphology 0.0192375033581862 0.0631309889228076 0.638523956723339 1 26.3 26 3 lymph node inflammation 0.0192375033581862 0.0631309889228076 0.638523956723339 1 26.3 26 3 abnormal skin development 0.0192375033581862 0.0631309889228076 0.638523956723339 1 26.3 26 3 tau protein deposits 0.0192375033581862 0.0631309889228076 0.638523956723339 1 26.3 26 3 abnormal extraembryonic tissue physiology 0.0192375033581862 0.0631309889228076 0.638523956723339 1 26.3 26 3 abnormal lateral ganglionic eminence morphology 0.0192375033581862 0.0631309889228076 0.638523956723339 1 26.3 26 3 long femur 0.0192375033581862 0.0631309889228076 0.638523956723339 1 26.3 26 3 thin stria vascularis 0.0192375033581862 0.0631309889228076 0.638523956723339 1 26.3 26 3 bowed fibula 0.0192375033581862 0.0631309889228076 0.638523956723339 1 26.3 26 3 small frontal bone 0.0192375033581862 0.0631309889228076 0.638523956723339 1 26.3 26 3 abnormal hair follicle melanocyte morphology 0.0192375033581862 0.0631309889228076 0.638523956723339 1 26.3 26 3 absent interparietal bone 0.0192375033581862 0.0631309889228076 0.638523956723339 1 26.3 26 3 accumulation of giant lysosomes in kidney/renal tubule cells 0.0192375033581862 0.0631309889228076 0.638523956723339 1 26.3 26 3 abnormal choroid pigmentation 0.0192375033581862 0.0631309889228076 0.638523956723339 1 26.3 26 3 non-pigmented tail tip 0.0192375033581862 0.0631309889228076 0.638523956723339 1 26.3 26 3 abnormal somite size 0.0192375033581862 0.0631309889228076 0.638523956723339 1 26.3 26 3 abnormal vertebral body development 0.0192375033581862 0.0631309889228076 0.638523956723339 1 26.3 26 3 abnormal olfactory tract morphology 0.0192375033581862 0.0631309889228076 0.638523956723339 1 26.3 26 3 ocular hypertension 0.0192375033581862 0.0631309889228076 0.638523956723339 1 26.3 26 3 craniofacial phenotype 0.0192375033581862 0.0631309889228076 0.638523956723339 1 26.3 26 3 absent outer ear 0.0192375033581862 0.0631309889228076 0.638523956723339 1 26.3 26 3 abnormal epidermal lamellar body morphology 0.0192375033581862 0.0631309889228076 0.638523956723339 1 26.3 26 3 impaired behavioral response to alcohol 0.0192375033581862 0.0631309889228076 0.638523956723339 1 26.3 26 3 abnormal meiotic spindle morphology 0.0192375033581862 0.0631309889228076 0.638523956723339 1 26.3 26 3 abnormal base-excision repair 0.0192375033581862 0.0631309889228076 0.638523956723339 1 26.3 26 3 abnormal sphingomyelin level 0.0192375033581862 0.0631309889228076 0.638523956723339 1 26.3 26 3 abnormal olfactory bulb glomerular layer morphology 0.0192375033581862 0.0631309889228076 0.638523956723339 1 26.3 26 3 abnormal olfactory bulb mitral cell layer morphology 0.0192375033581862 0.0631309889228076 0.638523956723339 1 26.3 26 3 abnormal cerebellum deep nucleus morphology 0.0192375033581862 0.0631309889228076 0.638523956723339 1 26.3 26 3 increased caudal vertebrae number 0.0192375033581862 0.0631309889228076 0.638523956723339 1 26.3 26 3 abnormal brain ependyma morphology 0.0192375033581862 0.0631309889228076 0.638523956723339 1 26.3 26 3 decreased quadriceps weight 0.0192375033581862 0.0631309889228076 0.638523956723339 1 26.3 26 3 pleural effusion 0.0192375033581862 0.0631309889228076 0.638523956723339 1 26.3 26 3 sinoatrial block 0.0192375033581862 0.0631309889228076 0.638523956723339 1 26.3 26 3 delayed suture closure 0.0192375033581862 0.0631309889228076 0.638523956723339 1 26.3 26 3 abnormal anterior commissure pars posterior morphology 0.0192375033581862 0.0631309889228076 0.638523956723339 1 26.3 26 3 decreased alveolar lamellar body number 0.0192375033581862 0.0631309889228076 0.638523956723339 1 26.3 26 3 increased airway resistance 0.0192375033581862 0.0631309889228076 0.638523956723339 1 26.3 26 3 abnormal maxillary prominence morphology 0.0192375033581862 0.0631309889228076 0.638523956723339 1 26.3 26 3 abnormal foramen magnum morphology 0.0192375033581862 0.0631309889228076 0.638523956723339 1 26.3 26 3 absent ureteric bud 0.0192375033581862 0.0631309889228076 0.638523956723339 1 26.3 26 3 abnormal branching involved in ureteric bud morphogenesis 0.0192375033581862 0.0631309889228076 0.638523956723339 1 26.3 26 3 abnormal kidney mesenchyme morphology 0.0192375033581862 0.0631309889228076 0.638523956723339 1 26.3 26 3 increased aorta wall thickness 0.0192375033581862 0.0631309889228076 0.638523956723339 1 26.3 26 3 impaired neuron differentiation 0.0192375033581862 0.0631309889228076 0.638523956723339 1 26.3 26 3 decreased cranium length 0.0192375033581862 0.0631309889228076 0.638523956723339 1 26.3 26 3 increased cardiac stroke volume 0.0192375033581862 0.0631309889228076 0.638523956723339 1 26.3 26 3 prolonged PQ interval 0.0192375033581862 0.0631309889228076 0.638523956723339 1 26.3 26 3 increased testis apoptosis 0.0192375033581862 0.0631309889228076 0.638523956723339 1 26.3 26 3 abnormal umbilical vein topology 0.0192375033581862 0.0631309889228076 0.638523956723339 1 26.3 26 3 increased mammary gland apoptosis 0.0192375033581862 0.0631309889228076 0.638523956723339 1 26.3 26 3 decreased white adipose tissue mass 0.0192375033581862 0.0631309889228076 0.638523956723339 1 26.3 26 3 increased brain apoptosis 0.0192375033581862 0.0631309889228076 0.638523956723339 1 26.3 26 3 decreased basal metabolism 0.0192375033581862 0.0631309889228076 0.638523956723339 1 26.3 26 3 decreased vascular endothelial cell proliferation 0.0192375033581862 0.0631309889228076 0.638523956723339 1 26.3 26 3 increased neuron apoptosis 4.00666640288399e-18 2.43550866280906e-16 0.638523956723339 1 26.3 26 3 abnormal maternal nurturing 8.00565486337464e-14 2.9502320700214e-12 0.638523956723339 1 26.3 26 3 abnormal maxilla morphology 2.5576155389811e-12 7.80621920639937e-11 0.638523956723339 1 26.3 26 3 short stride length 1.85069028806616e-11 4.7954084287131e-10 0.638523956723339 1 26.3 26 3 impaired branching involved in ureteric bud morphogenesis 6.99909022037506e-09 1.20070599470227e-07 0.638523956723339 1 26.3 26 3 abnormal breathing pattern 1.14761779792834e-08 1.88428994874373e-07 0.638523956723339 1 26.3 26 3 increased cardiomyocyte apoptosis 8.29350360440821e-08 1.22798156047413e-06 0.638523956723339 1 26.3 26 3 osteopetrosis 2.22925241678736e-07 3.02194299005916e-06 0.638523956723339 1 26.3 26 3 abnormal object recognition memory 2.22925241678736e-07 3.02194299005916e-06 0.638523956723339 1 26.3 26 3 abnormal circulating cholesterol level 9.82267119878814e-07 1.16351879080883e-05 0.638523956723339 1 26.3 26 3 myoclonus 9.82267119878814e-07 1.16351879080883e-05 0.638523956723339 1 26.3 26 3 shortened head 9.82267119878814e-07 1.16351879080883e-05 0.638523956723339 1 26.3 26 3 abnormal somite shape 9.82267119878814e-07 1.16351879080883e-05 0.638523956723339 1 26.3 26 3 abnormal atrioventricular cushion morphology 1.61028720619684e-06 1.80839251711722e-05 0.638523956723339 1 26.3 26 3 abnormal fetal cardiomyocyte proliferation 1.61028720619684e-06 1.80839251711722e-05 0.638523956723339 1 26.3 26 3 abnormal nasal bone morphology 2.63978700627047e-06 2.83648819788241e-05 0.638523956723339 1 26.3 26 3 abnormal Schwann cell morphology 2.63978700627047e-06 2.83648819788241e-05 0.638523956723339 1 26.3 26 3 abnormal erythrocyte osmotic lysis 2.63978700627047e-06 2.83648819788241e-05 0.638523956723339 1 26.3 26 3 abnormal nerve conduction 2.63978700627047e-06 2.83648819788241e-05 0.638523956723339 1 26.3 26 3 mandible hypoplasia 4.32739202696274e-06 4.44809407730158e-05 0.638523956723339 1 26.3 26 3 abnormal nest building behavior 4.32739202696274e-06 4.44809407730158e-05 0.638523956723339 1 26.3 26 3 abnormal digestive system morphology 7.09374224922809e-06 7.05827353798195e-05 0.638523956723339 1 26.3 26 3 ocular hypertelorism 7.09374224922809e-06 7.05827353798195e-05 0.638523956723339 1 26.3 26 3 abnormal nursing 7.09374224922809e-06 7.05827353798195e-05 0.638523956723339 1 26.3 26 3 abnormal vasodilation 7.09374224922809e-06 7.05827353798195e-05 0.638523956723339 1 26.3 26 3 abnormal impulse conducting system conduction 7.09374224922809e-06 7.05827353798195e-05 0.638523956723339 1 26.3 26 3 increased hemangiosarcoma incidence 7.09374224922809e-06 7.05827353798195e-05 0.638523956723339 1 26.3 26 3 abnormal embryonic/fetal subventricular zone morphology 3.12445131738392e-05 0.000263014302943908 0.638523956723339 1 26.3 26 3 absent segment of posterior cerebral artery 3.12445131738392e-05 0.000263014302943908 0.638523956723339 1 26.3 26 3 abnormal basioccipital bone morphology 5.12141739821041e-05 0.00040963105395654 0.638523956723339 1 26.3 26 3 abnormal pericardium morphology 5.12141739821041e-05 0.00040963105395654 0.638523956723339 1 26.3 26 3 abnormal fibula morphology 5.12141739821041e-05 0.00040963105395654 0.638523956723339 1 26.3 26 3 kyphoscoliosis 8.39456886083268e-05 0.000632772425494585 0.638523956723339 1 26.3 26 3 increased malignant tumor incidence 8.39456886083268e-05 0.000632772425494585 0.638523956723339 1 26.3 26 3 abnormal ear morphology 8.39456886083268e-05 0.000632772425494585 0.638523956723339 1 26.3 26 3 decreased germ cell number 8.39456886083268e-05 0.000632772425494585 0.638523956723339 1 26.3 26 3 abnormal nasal septum morphology 8.39456886083268e-05 0.000632772425494585 0.638523956723339 1 26.3 26 3 maternal imprinting 8.39456886083268e-05 0.000632772425494585 0.638523956723339 1 26.3 26 3 increased liver adenoma incidence 8.39456886083268e-05 0.000632772425494585 0.638523956723339 1 26.3 26 3 increased left ventricle weight 8.39456886083268e-05 0.000632772425494585 0.638523956723339 1 26.3 26 3 abnormal sternebra morphology 8.39456886083268e-05 0.000632772425494585 0.638523956723339 1 26.3 26 3 increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 8.39456886083268e-05 0.000632772425494585 0.638523956723339 1 26.3 26 3 abnormal adipose tissue morphology 0.000225522711836393 0.00147813013938293 0.638523956723339 1 26.3 26 3 abnormal bone marrow cavity morphology 0.000225522711836393 0.00147813013938293 0.638523956723339 1 26.3 26 3 abnormal interatrial septum morphology 0.000225522711836393 0.00147813013938293 0.638523956723339 1 26.3 26 3 hyperlipidemia 0.000225522711836393 0.00147813013938293 0.638523956723339 1 26.3 26 3 abnormal dorsal-ventral axis patterning 0.000225522711836393 0.00147813013938293 0.638523956723339 1 26.3 26 3 absence seizures 0.000225522711836393 0.00147813013938293 0.638523956723339 1 26.3 26 3 aminoaciduria 0.000225522711836393 0.00147813013938293 0.638523956723339 1 26.3 26 3 abnormal involuntary movement 0.000225522711836393 0.00147813013938293 0.638523956723339 1 26.3 26 3 increased brain size 0.000225522711836393 0.00147813013938293 0.638523956723339 1 26.3 26 3 coloboma 0.000225522711836393 0.00147813013938293 0.638523956723339 1 26.3 26 3 midline facial cleft 0.000992925659271721 0.00536935342921392 0.638523956723339 1 26.3 26 3 irregularly shaped pupil 0.000992925659271721 0.00536935342921392 0.638523956723339 1 26.3 26 3 increased aggression towards males 0.000992925659271721 0.00536935342921392 0.638523956723339 1 26.3 26 3 absent visceral yolk sac blood islands 0.000992925659271721 0.00536935342921392 0.638523956723339 1 26.3 26 3 abnormal adrenal gland secretion 0.000992925659271721 0.00536935342921392 0.638523956723339 1 26.3 26 3 increased hemangioma incidence 0.000992925659271721 0.00536935342921392 0.638523956723339 1 26.3 26 3 abnormal kidney medulla morphology 0.000992925659271721 0.00536935342921392 0.638523956723339 1 26.3 26 3 amyloid beta deposits 0.000992925659271721 0.00536935342921392 0.638523956723339 1 26.3 26 3 abnormal ventral body wall morphology 0.000992925659271721 0.00536935342921392 0.638523956723339 1 26.3 26 3 absent olfactory bulb 0.000992925659271721 0.00536935342921392 0.638523956723339 1 26.3 26 3 abnormal sagittal suture morphology 0.000992925659271721 0.00536935342921392 0.638523956723339 1 26.3 26 3 abnormal pancreas development 0.000992925659271721 0.00536935342921392 0.638523956723339 1 26.3 26 3 lysosomal protein accumulation 0.000992925659271721 0.00536935342921392 0.638523956723339 1 26.3 26 3 decreased tongue size 0.000992925659271721 0.00536935342921392 0.638523956723339 1 26.3 26 3 testis degeneration 0.000992925659271721 0.00536935342921392 0.638523956723339 1 26.3 26 3 absent teeth 0.00162733082168882 0.00820260469898873 0.638523956723339 1 26.3 26 3 absent myocardial trabeculae 0.00162733082168882 0.00820260469898873 0.638523956723339 1 26.3 26 3 absent trabeculae carneae 0.00162733082168882 0.00820260469898873 0.638523956723339 1 26.3 26 3 short hair 0.00162733082168882 0.00820260469898873 0.638523956723339 1 26.3 26 3 abnormal sympathetic ganglion morphology 0.00162733082168882 0.00820260469898873 0.638523956723339 1 26.3 26 3 excessive scratching 0.00162733082168882 0.00820260469898873 0.638523956723339 1 26.3 26 3 dystrophic cardiac calcinosis 0.00162733082168882 0.00820260469898873 0.638523956723339 1 26.3 26 3 abnormal otolith morphology 0.00162733082168882 0.00820260469898873 0.638523956723339 1 26.3 26 3 abnormal soleus morphology 0.00162733082168882 0.00820260469898873 0.638523956723339 1 26.3 26 3 anal atresia 0.00162733082168882 0.00820260469898873 0.638523956723339 1 26.3 26 3 abnormal telomere length 0.00162733082168882 0.00820260469898873 0.638523956723339 1 26.3 26 3 abnormal GABAergic neuron morphology 0.00162733082168882 0.00820260469898873 0.638523956723339 1 26.3 26 3 tracheoesophageal fistula 0.00162733082168882 0.00820260469898873 0.638523956723339 1 26.3 26 3 abnormal insulin secretion 0.00162733082168882 0.00820260469898873 0.638523956723339 1 26.3 26 3 abnormal retinal inner plexiform layer morphology 0.00162733082168882 0.00820260469898873 0.638523956723339 1 26.3 26 3 increased cochlear inner hair cell number 0.00162733082168882 0.00820260469898873 0.638523956723339 1 26.3 26 3 abnormal exocrine pancreas morphology 0.00162733082168882 0.00820260469898873 0.638523956723339 1 26.3 26 3 small pituitary gland 0.00162733082168882 0.00820260469898873 0.638523956723339 1 26.3 26 3 increased prostaglandin level 0.00162733082168882 0.00820260469898873 0.638523956723339 1 26.3 26 3 abnormal supraoccipital bone morphology 0.00266702314059111 0.0122337633611439 0.638523956723339 1 26.3 26 3 abnormal mineral level 0.00266702314059111 0.0122337633611439 0.638523956723339 1 26.3 26 3 abnormal rectum morphology 0.00266702314059111 0.0122337633611439 0.638523956723339 1 26.3 26 3 abnormal superior cervical ganglion morphology 0.00266702314059111 0.0122337633611439 0.638523956723339 1 26.3 26 3 absent optic nerve 0.00266702314059111 0.0122337633611439 0.638523956723339 1 26.3 26 3 increased papilloma incidence 0.00266702314059111 0.0122337633611439 0.638523956723339 1 26.3 26 3 abnormal embryonic growth/weight/body size 0.00266702314059111 0.0122337633611439 0.638523956723339 1 26.3 26 3 abnormal respiratory function 0.00266702314059111 0.0122337633611439 0.638523956723339 1 26.3 26 3 abnormal corticospinal tract morphology 0.00266702314059111 0.0122337633611439 0.638523956723339 1 26.3 26 3 decreased synaptic depression 0.00266702314059111 0.0122337633611439 0.638523956723339 1 26.3 26 3 abnormal alisphenoid bone morphology 0.00266702314059111 0.0122337633611439 0.638523956723339 1 26.3 26 3 loss of dopaminergic neurons 0.00266702314059111 0.0122337633611439 0.638523956723339 1 26.3 26 3 absent ovary 0.00266702314059111 0.0122337633611439 0.638523956723339 1 26.3 26 3 decreased left ventricle systolic pressure 0.00266702314059111 0.0122337633611439 0.638523956723339 1 26.3 26 3 abnormal defecation 0.00266702314059111 0.0122337633611439 0.638523956723339 1 26.3 26 3 abnormal rostral-caudal body axis extension 0.00266702314059111 0.0122337633611439 0.638523956723339 1 26.3 26 3 pale placenta 0.00266702314059111 0.0122337633611439 0.638523956723339 1 26.3 26 3 vestibular saccular macula degeneration 0.00266702314059111 0.0122337633611439 0.638523956723339 1 26.3 26 3 stria vascularis degeneration 0.00266702314059111 0.0122337633611439 0.638523956723339 1 26.3 26 3 small parietal bone 0.00266702314059111 0.0122337633611439 0.638523956723339 1 26.3 26 3 hematuria 0.00266702314059111 0.0122337633611439 0.638523956723339 1 26.3 26 3 abnormal palatine bone morphology 0.00266702314059111 0.0122337633611439 0.638523956723339 1 26.3 26 3 decreased renal glomerular filtration rate 0.00266702314059111 0.0122337633611439 0.638523956723339 1 26.3 26 3 decreased prostaglandin level 0.00266702314059111 0.0122337633611439 0.638523956723339 1 26.3 26 3 decreased red blood cell distribution width 0.00266702314059111 0.0122337633611439 0.638523956723339 1 26.3 26 3 increased fibrosarcoma incidence 0.00266702314059111 0.0122337633611439 0.638523956723339 1 26.3 26 3 persistent right dorsal aorta 0.00266702314059111 0.0122337633611439 0.638523956723339 1 26.3 26 3 prenatal growth retardation 0.00266702314059111 0.0122337633611439 0.638523956723339 1 26.3 26 3 embryonic lethality between implantation and placentation, incomplete penetrance 0.00266702314059111 0.0122337633611439 0.638523956723339 1 26.3 26 3 abnormal colon goblet cell morphology 0.00266702314059111 0.0122337633611439 0.638523956723339 1 26.3 26 3 abnormal auchene hair morphology 0.00716315101440672 0.0278411533567761 0.638523956723339 1 26.3 26 3 absent maxillary shelf 0.00716315101440672 0.0278411533567761 0.638523956723339 1 26.3 26 3 absent palatine bone horizontal plate 0.00716315101440672 0.0278411533567761 0.638523956723339 1 26.3 26 3 increased cranium width 0.00716315101440672 0.0278411533567761 0.638523956723339 1 26.3 26 3 kidney hemorrhage 0.00716315101440672 0.0278411533567761 0.638523956723339 1 26.3 26 3 jaundice 0.00716315101440672 0.0278411533567761 0.638523956723339 1 26.3 26 3 enlarged testis 0.00716315101440672 0.0278411533567761 0.638523956723339 1 26.3 26 3 abnormal grooming behavior 0.00716315101440672 0.0278411533567761 0.638523956723339 1 26.3 26 3 alcohol preference 0.00716315101440672 0.0278411533567761 0.638523956723339 1 26.3 26 3 abnormal respiratory mechanics 0.00716315101440672 0.0278411533567761 0.638523956723339 1 26.3 26 3 ketoaciduria 0.00716315101440672 0.0278411533567761 0.638523956723339 1 26.3 26 3 abnormal neuron specification 0.00716315101440672 0.0278411533567761 0.638523956723339 1 26.3 26 3 impaired social transmission of food preference 0.00716315101440672 0.0278411533567761 0.638523956723339 1 26.3 26 3 impaired basement membrane formation 0.00716315101440672 0.0278411533567761 0.638523956723339 1 26.3 26 3 abnormal tibialis anterior morphology 0.00716315101440672 0.0278411533567761 0.638523956723339 1 26.3 26 3 acrania 0.00716315101440672 0.0278411533567761 0.638523956723339 1 26.3 26 3 abnormal scala media morphology 0.00716315101440672 0.0278411533567761 0.638523956723339 1 26.3 26 3 intestinal hypoperistalsis 0.00716315101440672 0.0278411533567761 0.638523956723339 1 26.3 26 3 peritoneal inflammation 0.00716315101440672 0.0278411533567761 0.638523956723339 1 26.3 26 3 abnormal hypaxial muscle morphology 0.00716315101440672 0.0278411533567761 0.638523956723339 1 26.3 26 3 increased atrioventricular cushion size 0.00716315101440672 0.0278411533567761 0.638523956723339 1 26.3 26 3 increased left ventricle diastolic pressure 0.00716315101440672 0.0278411533567761 0.638523956723339 1 26.3 26 3 abnormal hindlimb zeugopod morphology 0.00716315101440672 0.0278411533567761 0.638523956723339 1 26.3 26 3 absent pharyngeal arches 0.00716315101440672 0.0278411533567761 0.638523956723339 1 26.3 26 3 abnormal ear physiology 0.00716315101440672 0.0278411533567761 0.638523956723339 1 26.3 26 3 increased heart rate variability 0.00716315101440672 0.0278411533567761 0.638523956723339 1 26.3 26 3 abnormal plasma membrane morphology 0.00716315101440672 0.0278411533567761 0.638523956723339 1 26.3 26 3 abnormal embryonic erythrocyte morphology 0.00716315101440672 0.0278411533567761 0.638523956723339 1 26.3 26 3 abnormal cochlear inner hair cell physiology 0.00716315101440672 0.0278411533567761 0.638523956723339 1 26.3 26 3 osteosclerosis 0.00716315101440672 0.0278411533567761 0.638523956723339 1 26.3 26 3 tachypnea 0.00716315101440672 0.0278411533567761 0.638523956723339 1 26.3 26 3 crystalluria 0.00716315101440672 0.0278411533567761 0.638523956723339 1 26.3 26 3 ventricular premature beat 0.00716315101440672 0.0278411533567761 0.638523956723339 1 26.3 26 3 protruding tongue 0.00716315101440672 0.0278411533567761 0.638523956723339 1 26.3 26 3 abnormal hippocampus neuron morphology 0.00716315101440672 0.0278411533567761 0.638523956723339 1 26.3 26 3 abnormal cerebellar granule cell migration 0.00716315101440672 0.0278411533567761 0.638523956723339 1 26.3 26 3 increased circulating fructosamine level 0.00716315101440672 0.0278411533567761 0.638523956723339 1 26.3 26 3 umbilical hernia 0.00716315101440672 0.0278411533567761 0.638523956723339 1 26.3 26 3 acanthocytosis 0.00716315101440672 0.0278411533567761 0.638523956723339 1 26.3 26 3 increased T-helper 17 cell number 0.00716315101440672 0.0278411533567761 0.638523956723339 1 26.3 26 3 common ventricle 0.00716315101440672 0.0278411533567761 0.638523956723339 1 26.3 26 3 aorta stenosis 0.00716315101440672 0.0278411533567761 0.638523956723339 1 26.3 26 3 abnormal left subclavian artery morphology 0.00716315101440672 0.0278411533567761 0.638523956723339 1 26.3 26 3 abnormal inferior vena cava valve morphology 0.00716315101440672 0.0278411533567761 0.638523956723339 1 26.3 26 3 thin ventricle myocardium compact layer 0.00716315101440672 0.0278411533567761 0.638523956723339 1 26.3 26 3 abnormal adaptive thermogenesis 0.00716315101440672 0.0278411533567761 0.638523956723339 1 26.3 26 3 abnormal circadian temperature homeostasis 0.00716315101440672 0.0278411533567761 0.638523956723339 1 26.3 26 3 lethality during fetal growth through weaning, complete penetrance 0.00716315101440672 0.0278411533567761 0.638523956723339 1 26.3 26 3 decreased circulating lactate level 0.00716315101440672 0.0278411533567761 0.638523956723339 1 26.3 26 3 increased fatty acid oxidation 0.00716315101440672 0.0278411533567761 0.638523956723339 1 26.3 26 3 cochlear degeneration 0.0315252645987149 0.0946518958229369 0.638523956723339 1 26.3 26 3 failure of atrioventricular cushion closure 0.0315252645987149 0.0946518958229369 0.638523956723339 1 26.3 26 3 broad head 0.0315252645987149 0.0946518958229369 0.638523956723339 1 26.3 26 3 polyphalangy 0.0315252645987149 0.0946518958229369 0.638523956723339 1 26.3 26 3 mammary gland hyperplasia 0.0315252645987149 0.0946518958229369 0.638523956723339 1 26.3 26 3 skin photosensitivity 0.0315252645987149 0.0946518958229369 0.638523956723339 1 26.3 26 3 absent epidermis stratum corneum 0.0315252645987149 0.0946518958229369 0.638523956723339 1 26.3 26 3 retina hyperplasia 0.0315252645987149 0.0946518958229369 0.638523956723339 1 26.3 26 3 excessive tearing 0.0315252645987149 0.0946518958229369 0.638523956723339 1 26.3 26 3 limp posture 0.0315252645987149 0.0946518958229369 0.638523956723339 1 26.3 26 3 abnormal circulating free fatty acids level 0.0315252645987149 0.0946518958229369 0.638523956723339 1 26.3 26 3 abnormal circulating alanine transaminase level 0.0315252645987149 0.0946518958229369 0.638523956723339 1 26.3 26 3 abnormal tumor incidence 0.0315252645987149 0.0946518958229369 0.638523956723339 1 26.3 26 3 abnormal brain ventricular system morphology 0.0315252645987149 0.0946518958229369 0.638523956723339 1 26.3 26 3 abnormal melanocyte morphology 0.0315252645987149 0.0946518958229369 0.638523956723339 1 26.3 26 3 abnormal adrenal gland physiology 0.0315252645987149 0.0946518958229369 0.638523956723339 1 26.3 26 3 abnormal inhibitory postsynaptic potential 0.0315252645987149 0.0946518958229369 0.638523956723339 1 26.3 26 3 increased retinal ganglion cell number 0.0315252645987149 0.0946518958229369 0.638523956723339 1 26.3 26 3 absent tunnel of Corti 0.0315252645987149 0.0946518958229369 0.638523956723339 1 26.3 26 3 decreased lateral semicircular canal size 0.0315252645987149 0.0946518958229369 0.638523956723339 1 26.3 26 3 decreased cardiomyocyte apoptosis 0.0315252645987149 0.0946518958229369 0.638523956723339 1 26.3 26 3 anuria 0.0315252645987149 0.0946518958229369 0.638523956723339 1 26.3 26 3 increased cell nucleus count 0.0315252645987149 0.0946518958229369 0.638523956723339 1 26.3 26 3 abnormal central pattern generator function 0.0315252645987149 0.0946518958229369 0.638523956723339 1 26.3 26 3 abnormal Purkinje cell innervation 0.0315252645987149 0.0946518958229369 0.638523956723339 1 26.3 26 3 abnormal optic tract morphology 0.0315252645987149 0.0946518958229369 0.638523956723339 1 26.3 26 3 abnormal organ of Corti supporting cell morphology 0.0315252645987149 0.0946518958229369 0.638523956723339 1 26.3 26 3 utricular macular degeneration 0.0315252645987149 0.0946518958229369 0.638523956723339 1 26.3 26 3 absent deltoid tuberosity 0.0315252645987149 0.0946518958229369 0.638523956723339 1 26.3 26 3 absent ulna 0.0315252645987149 0.0946518958229369 0.638523956723339 1 26.3 26 3 abnormal strial marginal cell morphology 0.0315252645987149 0.0946518958229369 0.638523956723339 1 26.3 26 3 absent endocochlear potential 0.0315252645987149 0.0946518958229369 0.638523956723339 1 26.3 26 3 abnormal cochlear nerve compound action potential 0.0315252645987149 0.0946518958229369 0.638523956723339 1 26.3 26 3 abnormal talus morphology 0.0315252645987149 0.0946518958229369 0.638523956723339 1 26.3 26 3 increased adrenocorticotropin level 0.0315252645987149 0.0946518958229369 0.638523956723339 1 26.3 26 3 urolithiasis 0.0315252645987149 0.0946518958229369 0.638523956723339 1 26.3 26 3 absent fibula 0.0315252645987149 0.0946518958229369 0.638523956723339 1 26.3 26 3 abnormal thyroid hormone level 0.0315252645987149 0.0946518958229369 0.638523956723339 1 26.3 26 3 retinal pigment epithelium atrophy 0.0315252645987149 0.0946518958229369 0.638523956723339 1 26.3 26 3 decreased tidal volume 0.0315252645987149 0.0946518958229369 0.638523956723339 1 26.3 26 3 increased keratinocyte apoptosis 0.0315252645987149 0.0946518958229369 0.638523956723339 1 26.3 26 3 absent popliteal lymph nodes 0.0315252645987149 0.0946518958229369 0.638523956723339 1 26.3 26 3 uremia 0.0315252645987149 0.0946518958229369 0.638523956723339 1 26.3 26 3 decreased behavioral withdrawal response 0.0315252645987149 0.0946518958229369 0.638523956723339 1 26.3 26 3 abnormal cerebellum white matter morphology 0.0315252645987149 0.0946518958229369 0.638523956723339 1 26.3 26 3 decreased DN2 thymocyte number 0.0315252645987149 0.0946518958229369 0.638523956723339 1 26.3 26 3 increased DN3 thymocyte number 0.0315252645987149 0.0946518958229369 0.638523956723339 1 26.3 26 3 decreased DN4 thymocyte number 0.0315252645987149 0.0946518958229369 0.638523956723339 1 26.3 26 3 increased oligodendrocyte number 0.0315252645987149 0.0946518958229369 0.638523956723339 1 26.3 26 3 decreased brain cholesterol level 0.0315252645987149 0.0946518958229369 0.638523956723339 1 26.3 26 3 increased quadriceps weight 0.0315252645987149 0.0946518958229369 0.638523956723339 1 26.3 26 3 decreased skeletal muscle glycogen level 0.0315252645987149 0.0946518958229369 0.638523956723339 1 26.3 26 3 coronary fistula 0.0315252645987149 0.0946518958229369 0.638523956723339 1 26.3 26 3 long stride length 0.0315252645987149 0.0946518958229369 0.638523956723339 1 26.3 26 3 heart block 0.0315252645987149 0.0946518958229369 0.638523956723339 1 26.3 26 3 abnormal conotruncal ridge morphology 0.0315252645987149 0.0946518958229369 0.638523956723339 1 26.3 26 3 abnormal aortic valve cusp morphology 0.0315252645987149 0.0946518958229369 0.638523956723339 1 26.3 26 3 small lung saccule 0.0315252645987149 0.0946518958229369 0.638523956723339 1 26.3 26 3 abnormal tricarboxylic acid cycle 0.0315252645987149 0.0946518958229369 0.638523956723339 1 26.3 26 3 small lung lobe 0.0315252645987149 0.0946518958229369 0.638523956723339 1 26.3 26 3 abnormal outer hair cell kinocilium morphology 0.0315252645987149 0.0946518958229369 0.638523956723339 1 26.3 26 3 small tail bud 0.0315252645987149 0.0946518958229369 0.638523956723339 1 26.3 26 3 decreased CD8-positive, naive alpha-beta T cell number 0.0315252645987149 0.0946518958229369 0.638523956723339 1 26.3 26 3 dysmyelination 0.0315252645987149 0.0946518958229369 0.638523956723339 1 26.3 26 3 decreased volumetric bone mineral density 0.0315252645987149 0.0946518958229369 0.638523956723339 1 26.3 26 3 decreased areal bone mineral density 0.0315252645987149 0.0946518958229369 0.638523956723339 1 26.3 26 3 decreased femur compact bone thickness 0.0315252645987149 0.0946518958229369 0.638523956723339 1 26.3 26 3 ductus venosus stenosis 0.0315252645987149 0.0946518958229369 0.638523956723339 1 26.3 26 3 fragmented Meckel's cartilage 0.0315252645987149 0.0946518958229369 0.638523956723339 1 26.3 26 3 absent connection between subcutaneous lymph vessels and lymph sac 0.0315252645987149 0.0946518958229369 0.638523956723339 1 26.3 26 3 abnormal ear shape 0.0516607365281288 0.138327321973865 0.638523956723339 1 26.3 26 3 large anterior fontanelle 0.0516607365281288 0.138327321973865 0.638523956723339 1 26.3 26 3 arrest of tooth development 0.0516607365281288 0.138327321973865 0.638523956723339 1 26.3 26 3 echinocytosis 0.0516607365281288 0.138327321973865 0.638523956723339 1 26.3 26 3 absent organized vascular network 0.0516607365281288 0.138327321973865 0.638523956723339 1 26.3 26 3 hemoglobinuria 0.0516607365281288 0.138327321973865 0.638523956723339 1 26.3 26 3 abnormal urethra morphology 0.0516607365281288 0.138327321973865 0.638523956723339 1 26.3 26 3 absent radius 0.0516607365281288 0.138327321973865 0.638523956723339 1 26.3 26 3 ectopic digits 0.0516607365281288 0.138327321973865 0.638523956723339 1 26.3 26 3 thin tail 0.0516607365281288 0.138327321973865 0.638523956723339 1 26.3 26 3 absent superior cervical ganglion 0.0516607365281288 0.138327321973865 0.638523956723339 1 26.3 26 3 abnormal lacrimal gland physiology 0.0516607365281288 0.138327321973865 0.638523956723339 1 26.3 26 3 hyperresponsive 0.0516607365281288 0.138327321973865 0.638523956723339 1 26.3 26 3 jumpy 0.0516607365281288 0.138327321973865 0.638523956723339 1 26.3 26 3 increased embryo size 0.0516607365281288 0.138327321973865 0.638523956723339 1 26.3 26 3 absent ectoplacental cone 0.0516607365281288 0.138327321973865 0.638523956723339 1 26.3 26 3 delayed brain development 0.0516607365281288 0.138327321973865 0.638523956723339 1 26.3 26 3 non-obstructive hydrocephaly 0.0516607365281288 0.138327321973865 0.638523956723339 1 26.3 26 3 reduced NMDA-mediated synaptic currents 0.0516607365281288 0.138327321973865 0.638523956723339 1 26.3 26 3 abnormal gustatory system physiology 0.0516607365281288 0.138327321973865 0.638523956723339 1 26.3 26 3 abnormal gland physiology 0.0516607365281288 0.138327321973865 0.638523956723339 1 26.3 26 3 abnormal internal nares morphology 0.0516607365281288 0.138327321973865 0.638523956723339 1 26.3 26 3 abnormal pulmonary ventilation 0.0516607365281288 0.138327321973865 0.638523956723339 1 26.3 26 3 abnormal cervical lymph node morphology 0.0516607365281288 0.138327321973865 0.638523956723339 1 26.3 26 3 chromatolysis 0.0516607365281288 0.138327321973865 0.638523956723339 1 26.3 26 3 increased post-tetanic potentiation 0.0516607365281288 0.138327321973865 0.638523956723339 1 26.3 26 3 abnormal hippocampal fimbria morphology 0.0516607365281288 0.138327321973865 0.638523956723339 1 26.3 26 3 acidemia 0.0516607365281288 0.138327321973865 0.638523956723339 1 26.3 26 3 absent cochlea 0.0516607365281288 0.138327321973865 0.638523956723339 1 26.3 26 3 decreased posterior semicircular canal size 0.0516607365281288 0.138327321973865 0.638523956723339 1 26.3 26 3 phenotypic reversion 0.0516607365281288 0.138327321973865 0.638523956723339 1 26.3 26 3 loss of hippocampal neurons 0.0516607365281288 0.138327321973865 0.638523956723339 1 26.3 26 3 esophageal atresia 0.0516607365281288 0.138327321973865 0.638523956723339 1 26.3 26 3 abnormal intestinal peristalsis 0.0516607365281288 0.138327321973865 0.638523956723339 1 26.3 26 3 decreased liver function 0.0516607365281288 0.138327321973865 0.638523956723339 1 26.3 26 3 increased glycerol level 0.0516607365281288 0.138327321973865 0.638523956723339 1 26.3 26 3 enlarged pancreas 0.0516607365281288 0.138327321973865 0.638523956723339 1 26.3 26 3 short perineum 0.0516607365281288 0.138327321973865 0.638523956723339 1 26.3 26 3 ureter obstruction 0.0516607365281288 0.138327321973865 0.638523956723339 1 26.3 26 3 abnormal leukocyte tethering or rolling 0.0516607365281288 0.138327321973865 0.638523956723339 1 26.3 26 3 decreased heart right ventricle size 0.0516607365281288 0.138327321973865 0.638523956723339 1 26.3 26 3 abnormal milk ejection 0.0516607365281288 0.138327321973865 0.638523956723339 1 26.3 26 3 abnormal lambdoidal suture morphology 0.0516607365281288 0.138327321973865 0.638523956723339 1 26.3 26 3 abnormal metopic suture morphology 0.0516607365281288 0.138327321973865 0.638523956723339 1 26.3 26 3 matted coat 0.0516607365281288 0.138327321973865 0.638523956723339 1 26.3 26 3 abnormal ST segment 0.0516607365281288 0.138327321973865 0.638523956723339 1 26.3 26 3 shortened QT interval 0.0516607365281288 0.138327321973865 0.638523956723339 1 26.3 26 3 abnormal heart left atrium morphology 0.0516607365281288 0.138327321973865 0.638523956723339 1 26.3 26 3 absent molars 0.0516607365281288 0.138327321973865 0.638523956723339 1 26.3 26 3 abnormal motor nerve collateral sprouting 0.0516607365281288 0.138327321973865 0.638523956723339 1 26.3 26 3 abnormal extensor digitorum longus morphology 0.0516607365281288 0.138327321973865 0.638523956723339 1 26.3 26 3 abnormal physical strength 0.0516607365281288 0.138327321973865 0.638523956723339 1 26.3 26 3 absent incus 0.0516607365281288 0.138327321973865 0.638523956723339 1 26.3 26 3 vestibular saccular degeneration 0.0516607365281288 0.138327321973865 0.638523956723339 1 26.3 26 3 short scapula 0.0516607365281288 0.138327321973865 0.638523956723339 1 26.3 26 3 bowed humerus 0.0516607365281288 0.138327321973865 0.638523956723339 1 26.3 26 3 enlarged interparietal bone 0.0516607365281288 0.138327321973865 0.638523956723339 1 26.3 26 3 absent cochlear nerve compound action potential 0.0516607365281288 0.138327321973865 0.638523956723339 1 26.3 26 3 absent parietal bone 0.0516607365281288 0.138327321973865 0.638523956723339 1 26.3 26 3 abnormal common crus morphology 0.0516607365281288 0.138327321973865 0.638523956723339 1 26.3 26 3 decreased prostate gland weight 0.0516607365281288 0.138327321973865 0.638523956723339 1 26.3 26 3 abnormal immature B cell morphology 0.0516607365281288 0.138327321973865 0.638523956723339 1 26.3 26 3 osteomyelitis 0.0516607365281288 0.138327321973865 0.638523956723339 1 26.3 26 3 decreased susceptibility to fungal infection 0.0516607365281288 0.138327321973865 0.638523956723339 1 26.3 26 3 abnormal adipose tissue amount 0.0516607365281288 0.138327321973865 0.638523956723339 1 26.3 26 3 increased triiodothyronine level 0.0516607365281288 0.138327321973865 0.638523956723339 1 26.3 26 3 abnormal ligament morphology 0.0516607365281288 0.138327321973865 0.638523956723339 1 26.3 26 3 abnormal dermis papillary layer morphology 0.0516607365281288 0.138327321973865 0.638523956723339 1 26.3 26 3 decreased platelet ADP level 0.0516607365281288 0.138327321973865 0.638523956723339 1 26.3 26 3 abnormal right lung morphology 0.0516607365281288 0.138327321973865 0.638523956723339 1 26.3 26 3 abnormal eyelid development 0.0516607365281288 0.138327321973865 0.638523956723339 1 26.3 26 3 delayed chorioallantoic fusion 0.0516607365281288 0.138327321973865 0.638523956723339 1 26.3 26 3 increased urine uric acid level 0.0516607365281288 0.138327321973865 0.638523956723339 1 26.3 26 3 abnormal thromboxane level 0.0516607365281288 0.138327321973865 0.638523956723339 1 26.3 26 3 abnormal aorta tunica adventitia morphology 0.0516607365281288 0.138327321973865 0.638523956723339 1 26.3 26 3 increased transitional stage T1 B cell number 0.0516607365281288 0.138327321973865 0.638523956723339 1 26.3 26 3 abnormal olfactory bulb layer morphology 0.0516607365281288 0.138327321973865 0.638523956723339 1 26.3 26 3 ectopic hippocampus pyramidal cells 0.0516607365281288 0.138327321973865 0.638523956723339 1 26.3 26 3 abnormal orbit morphology 0.0516607365281288 0.138327321973865 0.638523956723339 1 26.3 26 3 increased erythrocyte clearance 0.0516607365281288 0.138327321973865 0.638523956723339 1 26.3 26 3 abnormal oval cell physiology 0.0516607365281288 0.138327321973865 0.638523956723339 1 26.3 26 3 enlarged lymphatic vessel 0.0516607365281288 0.138327321973865 0.638523956723339 1 26.3 26 3 abnormal acute phase protein level 0.0516607365281288 0.138327321973865 0.638523956723339 1 26.3 26 3 kidney microaneurysm 0.0516607365281288 0.138327321973865 0.638523956723339 1 26.3 26 3 myocardium hypoplasia 0.0516607365281288 0.138327321973865 0.638523956723339 1 26.3 26 3 cerebral arteriovenous malformation 0.0516607365281288 0.138327321973865 0.638523956723339 1 26.3 26 3 common truncal valve 0.0516607365281288 0.138327321973865 0.638523956723339 1 26.3 26 3 absent third pharyngeal arch 0.0516607365281288 0.138327321973865 0.638523956723339 1 26.3 26 3 thick myocardium 0.0516607365281288 0.138327321973865 0.638523956723339 1 26.3 26 3 persistent hyperplastic primary vitreous 0.0516607365281288 0.138327321973865 0.638523956723339 1 26.3 26 3 abnormal pre-Botzinger complex physiology 0.0516607365281288 0.138327321973865 0.638523956723339 1 26.3 26 3 abnormal intestinal enteroendocrine cell morphology 0.0516607365281288 0.138327321973865 0.638523956723339 1 26.3 26 3 increased total lung capacity 0.0516607365281288 0.138327321973865 0.638523956723339 1 26.3 26 3 abnormal mandibular prominence morphology 0.0516607365281288 0.138327321973865 0.638523956723339 1 26.3 26 3 abnormal respiratory epithelium morphology 0.0516607365281288 0.138327321973865 0.638523956723339 1 26.3 26 3 ectopic ureteric bud 0.0516607365281288 0.138327321973865 0.638523956723339 1 26.3 26 3 abnormal ureteric bud elongation 0.0516607365281288 0.138327321973865 0.638523956723339 1 26.3 26 3 abnormal ureteric bud tip morphology 0.0516607365281288 0.138327321973865 0.638523956723339 1 26.3 26 3 abnormal kidney collecting duct epithelium morphology 0.0516607365281288 0.138327321973865 0.638523956723339 1 26.3 26 3 podocyte hypertrophy 0.0516607365281288 0.138327321973865 0.638523956723339 1 26.3 26 3 abnormal endocrine pancreas development 0.0516607365281288 0.138327321973865 0.638523956723339 1 26.3 26 3 increased total retina thickness 0.0516607365281288 0.138327321973865 0.638523956723339 1 26.3 26 3 delayed limb development 0.0516607365281288 0.138327321973865 0.638523956723339 1 26.3 26 3 abnormal Rathke's pouch development 0.0516607365281288 0.138327321973865 0.638523956723339 1 26.3 26 3 increased bone trabecular spacing 0.0516607365281288 0.138327321973865 0.638523956723339 1 26.3 26 3 increased effector memory T-helper cell number 0.0516607365281288 0.138327321973865 0.638523956723339 1 26.3 26 3 absent embryonic telencephalon 0.0516607365281288 0.138327321973865 0.638523956723339 1 26.3 26 3 abnormal vertebral artery origin 0.0516607365281288 0.138327321973865 0.638523956723339 1 26.3 26 3 additional anastomosis between intracranial vertebral arteries 0.0516607365281288 0.138327321973865 0.638523956723339 1 26.3 26 3 abnormal Wolffian duct connection 0.0516607365281288 0.138327321973865 0.638523956723339 1 26.3 26 3 increased body fat mass 0.0516607365281288 0.138327321973865 0.638523956723339 1 26.3 26 3 ectopic bone 0.0516607365281288 0.138327321973865 0.638523956723339 1 26.3 26 3 decreased hippocampus volume 0.0516607365281288 0.138327321973865 0.638523956723339 1 26.3 26 3 decreased tear production 0.0516607365281288 0.138327321973865 0.638523956723339 1 26.3 26 3 decreased capillary density 0.0516607365281288 0.138327321973865 0.638523956723339 1 26.3 26 3 abnormal excitatory synapse morphology 0.0516607365281288 0.138327321973865 0.638523956723339 1 26.3 26 3 decreased retinal apoptosis 0.0516607365281288 0.138327321973865 0.638523956723339 1 26.3 26 3 increased cardiac cell glucose uptake 0.0516607365281288 0.138327321973865 0.638523956723339 1 26.3 26 3 absent organ of Corti 0.0846553225903474 0.196345095518405 0.638523956723339 1 26.3 26 3 absent neurocranium 0.0846553225903474 0.196345095518405 0.638523956723339 1 26.3 26 3 abnormal tooth eruption 0.0846553225903474 0.196345095518405 0.638523956723339 1 26.3 26 3 abnormal circulating HDL cholesterol level 0.0846553225903474 0.196345095518405 0.638523956723339 1 26.3 26 3 head blaze 0.0846553225903474 0.196345095518405 0.638523956723339 1 26.3 26 3 small hair follicles 0.0846553225903474 0.196345095518405 0.638523956723339 1 26.3 26 3 delayed intestine development 0.0846553225903474 0.196345095518405 0.638523956723339 1 26.3 26 3 abnormal pulmonary trunk morphology 0.0846553225903474 0.196345095518405 0.638523956723339 1 26.3 26 3 absent hindlimb 0.0846553225903474 0.196345095518405 0.638523956723339 1 26.3 26 3 abnormal pineal gland morphology 0.0846553225903474 0.196345095518405 0.638523956723339 1 26.3 26 3 optic nerve atrophy 0.0846553225903474 0.196345095518405 0.638523956723339 1 26.3 26 3 abnormal vestibulocochlear nerve morphology 0.0846553225903474 0.196345095518405 0.638523956723339 1 26.3 26 3 ovary hyperplasia 0.0846553225903474 0.196345095518405 0.638523956723339 1 26.3 26 3 absent prostate gland 0.0846553225903474 0.196345095518405 0.638523956723339 1 26.3 26 3 absent lungs 0.0846553225903474 0.196345095518405 0.638523956723339 1 26.3 26 3 decreased sensitivity to skin irradiation 0.0846553225903474 0.196345095518405 0.638523956723339 1 26.3 26 3 skin hyperplasia 0.0846553225903474 0.196345095518405 0.638523956723339 1 26.3 26 3 kinked vibrissae 0.0846553225903474 0.196345095518405 0.638523956723339 1 26.3 26 3 corneal scarring 0.0846553225903474 0.196345095518405 0.638523956723339 1 26.3 26 3 absent lacrimal glands 0.0846553225903474 0.196345095518405 0.638523956723339 1 26.3 26 3 abnormal penile erection 0.0846553225903474 0.196345095518405 0.638523956723339 1 26.3 26 3 abnormal respiratory sounds 0.0846553225903474 0.196345095518405 0.638523956723339 1 26.3 26 3 increased hepatic hemangioma incidence 0.0846553225903474 0.196345095518405 0.638523956723339 1 26.3 26 3 abnormal nasal mucosa morphology 0.0846553225903474 0.196345095518405 0.638523956723339 1 26.3 26 3 abnormal oropharynx morphology 0.0846553225903474 0.196345095518405 0.638523956723339 1 26.3 26 3 abnormal type I pneumocyte morphology 0.0846553225903474 0.196345095518405 0.638523956723339 1 26.3 26 3 anoxia 0.0846553225903474 0.196345095518405 0.638523956723339 1 26.3 26 3 hypercapnia 0.0846553225903474 0.196345095518405 0.638523956723339 1 26.3 26 3 improved righting response 0.0846553225903474 0.196345095518405 0.638523956723339 1 26.3 26 3 opisthotonus 0.0846553225903474 0.196345095518405 0.638523956723339 1 26.3 26 3 decreased superior colliculus size 0.0846553225903474 0.196345095518405 0.638523956723339 1 26.3 26 3 cerebral aqueductal stenosis 0.0846553225903474 0.196345095518405 0.638523956723339 1 26.3 26 3 increased urine microalbumin level 0.0846553225903474 0.196345095518405 0.638523956723339 1 26.3 26 3 abnormal urine osmolality 0.0846553225903474 0.196345095518405 0.638523956723339 1 26.3 26 3 decreased tendon stiffness 0.0846553225903474 0.196345095518405 0.638523956723339 1 26.3 26 3 absent malleus processus brevis 0.0846553225903474 0.196345095518405 0.638523956723339 1 26.3 26 3 abnormal esophagus development 0.0846553225903474 0.196345095518405 0.638523956723339 1 26.3 26 3 decreased lysosomal enzyme secretion 0.0846553225903474 0.196345095518405 0.638523956723339 1 26.3 26 3 increased lysosomal enzyme secretion 0.0846553225903474 0.196345095518405 0.638523956723339 1 26.3 26 3 enhanced NMDA-mediated synaptic currents 0.0846553225903474 0.196345095518405 0.638523956723339 1 26.3 26 3 gastric ulcer 0.0846553225903474 0.196345095518405 0.638523956723339 1 26.3 26 3 gastric polyps 0.0846553225903474 0.196345095518405 0.638523956723339 1 26.3 26 3 premature endochondral bone ossification 0.0846553225903474 0.196345095518405 0.638523956723339 1 26.3 26 3 sirenomelia 0.0846553225903474 0.196345095518405 0.638523956723339 1 26.3 26 3 increased thyroid adenoma incidence 0.0846553225903474 0.196345095518405 0.638523956723339 1 26.3 26 3 thyroid hypoplasia 0.0846553225903474 0.196345095518405 0.638523956723339 1 26.3 26 3 absent vas deferens 0.0846553225903474 0.196345095518405 0.638523956723339 1 26.3 26 3 absent uterus 0.0846553225903474 0.196345095518405 0.638523956723339 1 26.3 26 3 ischuria 0.0846553225903474 0.196345095518405 0.638523956723339 1 26.3 26 3 abnormal response to vitamins 0.0846553225903474 0.196345095518405 0.638523956723339 1 26.3 26 3 decreased skin turgor 0.0846553225903474 0.196345095518405 0.638523956723339 1 26.3 26 3 abnormal hypodermis morphology 0.0846553225903474 0.196345095518405 0.638523956723339 1 26.3 26 3 ectopic cartilage 0.0846553225903474 0.196345095518405 0.638523956723339 1 26.3 26 3 absent heart right ventricle 0.0846553225903474 0.196345095518405 0.638523956723339 1 26.3 26 3 increased allantois apoptosis 0.0846553225903474 0.196345095518405 0.638523956723339 1 26.3 26 3 increased heart right ventricle weight 0.0846553225903474 0.196345095518405 0.638523956723339 1 26.3 26 3 abnormal urinary system development 0.0846553225903474 0.196345095518405 0.638523956723339 1 26.3 26 3 abnormal Descemet membrane 0.0846553225903474 0.196345095518405 0.638523956723339 1 26.3 26 3 absent organ of Corti supporting cells 0.0846553225903474 0.196345095518405 0.638523956723339 1 26.3 26 3 abnormal Deiters cell morphology 0.0846553225903474 0.196345095518405 0.638523956723339 1 26.3 26 3 absent inner ear vestibule 0.0846553225903474 0.196345095518405 0.638523956723339 1 26.3 26 3 scapular bone foramen 0.0846553225903474 0.196345095518405 0.638523956723339 1 26.3 26 3 absent frontal bone 0.0846553225903474 0.196345095518405 0.638523956723339 1 26.3 26 3 abnormal inner cell mass proliferation 0.0846553225903474 0.196345095518405 0.638523956723339 1 26.3 26 3 erythroblastosis 0.0846553225903474 0.196345095518405 0.638523956723339 1 26.3 26 3 abnormal tail pigmentation 0.0846553225903474 0.196345095518405 0.638523956723339 1 26.3 26 3 abnormal olfactory cortex morphology 0.0846553225903474 0.196345095518405 0.638523956723339 1 26.3 26 3 decreased unsaturated fatty acid level 0.0846553225903474 0.196345095518405 0.638523956723339 1 26.3 26 3 abnormal mesangial cell morphology 0.0846553225903474 0.196345095518405 0.638523956723339 1 26.3 26 3 growth retardation of incisors 0.0846553225903474 0.196345095518405 0.638523956723339 1 26.3 26 3 intrahepatic cholestasis 0.0846553225903474 0.196345095518405 0.638523956723339 1 26.3 26 3 bronchial epithelial hyperplasia 0.0846553225903474 0.196345095518405 0.638523956723339 1 26.3 26 3 increased circulating atrial natriuretic factor 0.0846553225903474 0.196345095518405 0.638523956723339 1 26.3 26 3 corneal deposits 0.0846553225903474 0.196345095518405 0.638523956723339 1 26.3 26 3 abnormal hemoglobin content 0.0846553225903474 0.196345095518405 0.638523956723339 1 26.3 26 3 abnormal optokinetic reflex 0.0846553225903474 0.196345095518405 0.638523956723339 1 26.3 26 3 increased placenta apoptosis 0.0846553225903474 0.196345095518405 0.638523956723339 1 26.3 26 3 abnormal calcaneum morphology 0.0846553225903474 0.196345095518405 0.638523956723339 1 26.3 26 3 absent optic chiasm 0.0846553225903474 0.196345095518405 0.638523956723339 1 26.3 26 3 enhanced behavioral response to anesthetic 0.0846553225903474 0.196345095518405 0.638523956723339 1 26.3 26 3 abnormal mismatch repair 0.0846553225903474 0.196345095518405 0.638523956723339 1 26.3 26 3 decreased leukotriene level 0.0846553225903474 0.196345095518405 0.638523956723339 1 26.3 26 3 enlarged eye anterior chamber 0.0846553225903474 0.196345095518405 0.638523956723339 1 26.3 26 3 abnormal arcus anterior morphology 0.0846553225903474 0.196345095518405 0.638523956723339 1 26.3 26 3 palatal shelf fusion with tongue or mandible 0.0846553225903474 0.196345095518405 0.638523956723339 1 26.3 26 3 abnormal hyoid bone greater horn morphology 0.0846553225903474 0.196345095518405 0.638523956723339 1 26.3 26 3 abnormal tail hair pigmentation 0.0846553225903474 0.196345095518405 0.638523956723339 1 26.3 26 3 abnormal olfactory bulb granule cell layer morphology 0.0846553225903474 0.196345095518405 0.638523956723339 1 26.3 26 3 abnormal cerebellum lobule morphology 0.0846553225903474 0.196345095518405 0.638523956723339 1 26.3 26 3 aciduria 0.0846553225903474 0.196345095518405 0.638523956723339 1 26.3 26 3 abnormal cranium size 0.0846553225903474 0.196345095518405 0.638523956723339 1 26.3 26 3 abnormal primitive urogenital sinus morphology 0.0846553225903474 0.196345095518405 0.638523956723339 1 26.3 26 3 decreased DN3 thymocyte number 0.0846553225903474 0.196345095518405 0.638523956723339 1 26.3 26 3 hemolysis 0.0846553225903474 0.196345095518405 0.638523956723339 1 26.3 26 3 increased response to stress-induced hyperthermia 0.0846553225903474 0.196345095518405 0.638523956723339 1 26.3 26 3 increased mammary gland epithelial cell proliferation 0.0846553225903474 0.196345095518405 0.638523956723339 1 26.3 26 3 increased T follicular helper cell number 0.0846553225903474 0.196345095518405 0.638523956723339 1 26.3 26 3 abnormal lymphatic vessel endothelial cell morphology 0.0846553225903474 0.196345095518405 0.638523956723339 1 26.3 26 3 decreased lung tumor incidence 0.0846553225903474 0.196345095518405 0.638523956723339 1 26.3 26 3 fused first pharyngeal arch 0.0846553225903474 0.196345095518405 0.638523956723339 1 26.3 26 3 increased thyroid carcinoma incidence 0.0846553225903474 0.196345095518405 0.638523956723339 1 26.3 26 3 increased renal carcinoma incidence 0.0846553225903474 0.196345095518405 0.638523956723339 1 26.3 26 3 inlet ventricular septal defect 0.0846553225903474 0.196345095518405 0.638523956723339 1 26.3 26 3 calcified aorta 0.0846553225903474 0.196345095518405 0.638523956723339 1 26.3 26 3 aorta hypoplasia 0.0846553225903474 0.196345095518405 0.638523956723339 1 26.3 26 3 decreased heart left ventricle size 0.0846553225903474 0.196345095518405 0.638523956723339 1 26.3 26 3 enlarged aortic valve 0.0846553225903474 0.196345095518405 0.638523956723339 1 26.3 26 3 ventricular myocardium compact layer hypoplasia 0.0846553225903474 0.196345095518405 0.638523956723339 1 26.3 26 3 abnormal blood pressure regulation 0.0846553225903474 0.196345095518405 0.638523956723339 1 26.3 26 3 absent arcus anterior 0.0846553225903474 0.196345095518405 0.638523956723339 1 26.3 26 3 abnormal paranode morphology 0.0846553225903474 0.196345095518405 0.638523956723339 1 26.3 26 3 increased Schwann cell number 0.0846553225903474 0.196345095518405 0.638523956723339 1 26.3 26 3 preweaning lethality 0.0846553225903474 0.196345095518405 0.638523956723339 1 26.3 26 3 increased CD4-positive, alpha-beta memory T cell number 0.0846553225903474 0.196345095518405 0.638523956723339 1 26.3 26 3 pale lung 0.0846553225903474 0.196345095518405 0.638523956723339 1 26.3 26 3 pulmonary alveolar edema 0.0846553225903474 0.196345095518405 0.638523956723339 1 26.3 26 3 alveolitis 0.0846553225903474 0.196345095518405 0.638523956723339 1 26.3 26 3 fused right lung lobes 0.0846553225903474 0.196345095518405 0.638523956723339 1 26.3 26 3 abnormal nephrogenic mesenchyme morphogenesis 0.0846553225903474 0.196345095518405 0.638523956723339 1 26.3 26 3 abnormal lung alveolus development 0.0846553225903474 0.196345095518405 0.638523956723339 1 26.3 26 3 abnormal circadian regulation of heart rate 0.0846553225903474 0.196345095518405 0.638523956723339 1 26.3 26 3 abnormal circadian regulation of systemic arterial blood pressure 0.0846553225903474 0.196345095518405 0.638523956723339 1 26.3 26 3 impaired branching involved in terminal bronchiole morphogenesis 0.0846553225903474 0.196345095518405 0.638523956723339 1 26.3 26 3 increased macrophage cytokine production 0.0846553225903474 0.196345095518405 0.638523956723339 1 26.3 26 3 blind ureter 0.0846553225903474 0.196345095518405 0.638523956723339 1 26.3 26 3 decreased pre-pro B cell number 0.0846553225903474 0.196345095518405 0.638523956723339 1 26.3 26 3 cerebral edema 0.0846553225903474 0.196345095518405 0.638523956723339 1 26.3 26 3 podocyte microvillus transformation 0.0846553225903474 0.196345095518405 0.638523956723339 1 26.3 26 3 midface hypoplasia 0.0846553225903474 0.196345095518405 0.638523956723339 1 26.3 26 3 delayed optic fissure closure 0.0846553225903474 0.196345095518405 0.638523956723339 1 26.3 26 3 decreased Paneth cell number 0.0846553225903474 0.196345095518405 0.638523956723339 1 26.3 26 3 abnormal eyelid margin morphology 0.0846553225903474 0.196345095518405 0.638523956723339 1 26.3 26 3 abnormal mammary gland bud morphology 0.0846553225903474 0.196345095518405 0.638523956723339 1 26.3 26 3 abnormal mitophagy 0.0846553225903474 0.196345095518405 0.638523956723339 1 26.3 26 3 decreased small intestinal villus height 0.0846553225903474 0.196345095518405 0.638523956723339 1 26.3 26 3 cystinuria 0.0846553225903474 0.196345095518405 0.638523956723339 1 26.3 26 3 decreased fibroblast chemotaxis 0.0846553225903474 0.196345095518405 0.638523956723339 1 26.3 26 3 abnormal pharyngeal arch morphology 1.88167563074297e-08 2.98131728119308e-07 0.638523956723338 1 26.3 26 3 disorganized myocardium 3.6547490284701e-07 4.79457764665271e-06 0.638523956723338 1 26.3 26 3 aphagia 5.99166714969743e-07 7.37835249251106e-06 0.638523956723338 1 26.3 26 3 absent long term depression 5.99166714969743e-07 7.37835249251106e-06 0.638523956723338 1 26.3 26 3 abnormal outer ear morphology 5.99166714969743e-07 7.37835249251106e-06 0.638523956723338 1 26.3 26 3 abnormal blood vessel physiology 1.16283040467618e-05 0.000110327017661422 0.638523956723338 1 26.3 26 3 abnormal cranial nerve morphology 1.16283040467618e-05 0.000110327017661422 0.638523956723338 1 26.3 26 3 hypotension 1.16283040467618e-05 0.000110327017661422 0.638523956723338 1 26.3 26 3 prolonged PR interval 1.90611528765748e-05 0.000170863487497224 0.638523956723338 1 26.3 26 3 abnormal occipital bone morphology 1.90611528765748e-05 0.000170863487497224 0.638523956723338 1 26.3 26 3 pulmonary vascular congestion 1.90611528765748e-05 0.000170863487497224 0.638523956723338 1 26.3 26 3 abnormal mitral valve morphology 0.000137593663248281 0.000979694843302827 0.638523956723338 1 26.3 26 3 delayed kidney development 0.000137593663248281 0.000979694843302827 0.638523956723338 1 26.3 26 3 abnormal phrenic nerve morphology 0.000137593663248281 0.000979694843302827 0.638523956723338 1 26.3 26 3 blepharoptosis 0.000137593663248281 0.000979694843302827 0.638523956723338 1 26.3 26 3 abnormal thyroid cartilage morphology 0.000137593663248281 0.000979694843302827 0.638523956723338 1 26.3 26 3 increased circulating renin level 0.000137593663248281 0.000979694843302827 0.638523956723338 1 26.3 26 3 abnormal body wall morphology 0.000137593663248281 0.000979694843302827 0.638523956723338 1 26.3 26 3 absent ureter 0.000137593663248281 0.000979694843302827 0.638523956723338 1 26.3 26 3 darkened coat color 0.000137593663248281 0.000979694843302827 0.638523956723338 1 26.3 26 3 decreased lactate dehydrogenase level 0.000137593663248281 0.000979694843302827 0.638523956723338 1 26.3 26 3 small thoracic cage 0.000137593663248281 0.000979694843302827 0.638523956723338 1 26.3 26 3 atrioventricular block 0.000137593663248281 0.000979694843302827 0.638523956723338 1 26.3 26 3 increased effector memory CD4-positive, alpha-beta T cell number 0.000137593663248281 0.000979694843302827 0.638523956723338 1 26.3 26 3 abnormal metanephric mesenchyme morphology 0.000137593663248281 0.000979694843302827 0.638523956723338 1 26.3 26 3 abnormal fontanelle morphology 0.000605828130059921 0.00351281462359919 0.638523956723338 1 26.3 26 3 absent incisors 0.000605828130059921 0.00351281462359919 0.638523956723338 1 26.3 26 3 decreased hepatocyte number 0.000605828130059921 0.00351281462359919 0.638523956723338 1 26.3 26 3 abnormal enteric neuron morphology 0.000605828130059921 0.00351281462359919 0.638523956723338 1 26.3 26 3 abnormal pup retrieval 0.000605828130059921 0.00351281462359919 0.638523956723338 1 26.3 26 3 no suckling reflex 0.000605828130059921 0.00351281462359919 0.638523956723338 1 26.3 26 3 abnormal seizure response to electrical stimulation 0.000605828130059921 0.00351281462359919 0.638523956723338 1 26.3 26 3 abnormal apical ectodermal ridge morphology 0.000605828130059921 0.00351281462359919 0.638523956723338 1 26.3 26 3 placental labyrinth hypoplasia 0.000605828130059921 0.00351281462359919 0.638523956723338 1 26.3 26 3 delayed intramembranous bone ossification 0.000605828130059921 0.00351281462359919 0.638523956723338 1 26.3 26 3 abnormal glial cell morphology 0.000605828130059921 0.00351281462359919 0.638523956723338 1 26.3 26 3 abnormal placenta size 0.000605828130059921 0.00351281462359919 0.638523956723338 1 26.3 26 3 immune system phenotype 0.000605828130059921 0.00351281462359919 0.638523956723338 1 26.3 26 3 abnormal secondary palate development 0.000605828130059921 0.00351281462359919 0.638523956723338 1 26.3 26 3 liver vascular congestion 0.000605828130059921 0.00351281462359919 0.638523956723338 1 26.3 26 3 ostium primum atrial septal defect 0.000605828130059921 0.00351281462359919 0.638523956723338 1 26.3 26 3 premature suture closure 0.00437088656873659 0.018729681894457 0.638523956723338 1 26.3 26 3 abnormal sphenoid bone morphology 0.00437088656873659 0.018729681894457 0.638523956723338 1 26.3 26 3 decreased atrioventricular cushion size 0.00437088656873659 0.018729681894457 0.638523956723338 1 26.3 26 3 abnormal awl hair morphology 0.00437088656873659 0.018729681894457 0.638523956723338 1 26.3 26 3 delayed hepatic development 0.00437088656873659 0.018729681894457 0.638523956723338 1 26.3 26 3 abnormal food preference 0.00437088656873659 0.018729681894457 0.638523956723338 1 26.3 26 3 failure of somite differentiation 0.00437088656873659 0.018729681894457 0.638523956723338 1 26.3 26 3 abnormal proximal-distal axis patterning 0.00437088656873659 0.018729681894457 0.638523956723338 1 26.3 26 3 abnormal hypothalamus secretion 0.00437088656873659 0.018729681894457 0.638523956723338 1 26.3 26 3 retinal detachment 0.00437088656873659 0.018729681894457 0.638523956723338 1 26.3 26 3 patent ductus arteriosus 0.00437088656873659 0.018729681894457 0.638523956723338 1 26.3 26 3 pulmonary hypertension 0.00437088656873659 0.018729681894457 0.638523956723338 1 26.3 26 3 abnormal coronal suture morphology 0.00437088656873659 0.018729681894457 0.638523956723338 1 26.3 26 3 pharyngeal arch hypoplasia 0.00437088656873659 0.018729681894457 0.638523956723338 1 26.3 26 3 abnormal spinal cord ventral horn morphology 0.00437088656873659 0.018729681894457 0.638523956723338 1 26.3 26 3 increased motor neuron number 0.00437088656873659 0.018729681894457 0.638523956723338 1 26.3 26 3 abnormal dorsal-ventral polarity of the somites 0.00437088656873659 0.018729681894457 0.638523956723338 1 26.3 26 3 increased glycogen level 0.00437088656873659 0.018729681894457 0.638523956723338 1 26.3 26 3 abnormal palate development 0.00437088656873659 0.018729681894457 0.638523956723338 1 26.3 26 3 palatal shelf hypoplasia 0.00437088656873659 0.018729681894457 0.638523956723338 1 26.3 26 3 abnormal palatal shelf elevation 0.00437088656873659 0.018729681894457 0.638523956723338 1 26.3 26 3 aberrant origin of the right subclavian artery 0.00437088656873659 0.018729681894457 0.638523956723338 1 26.3 26 3 aorta dilation 0.00437088656873659 0.018729681894457 0.638523956723338 1 26.3 26 3 common atrioventricular valve 0.00437088656873659 0.018729681894457 0.638523956723338 1 26.3 26 3 abnormal pulmonary alveolar sac morphology 0.00437088656873659 0.018729681894457 0.638523956723338 1 26.3 26 3 thin hypoglossal nerve 0.00437088656873659 0.018729681894457 0.638523956723338 1 26.3 26 3 reduced sympathetic cervical ganglion size 0.00437088656873659 0.018729681894457 0.638523956723338 1 26.3 26 3 heart hyperplasia 0.0117389836508144 0.0420759680567735 0.638523956723338 1 26.3 26 3 distorted hair follicle pattern 0.0117389836508144 0.0420759680567735 0.638523956723338 1 26.3 26 3 abnormal head movements 0.0117389836508144 0.0420759680567735 0.638523956723338 1 26.3 26 3 renal tubular acidosis 0.0117389836508144 0.0420759680567735 0.638523956723338 1 26.3 26 3 abnormal sympathetic neuron morphology 0.0117389836508144 0.0420759680567735 0.638523956723338 1 26.3 26 3 abnormal geniculate ganglion morphology 0.0117389836508144 0.0420759680567735 0.638523956723338 1 26.3 26 3 abnormal kindling response 0.0117389836508144 0.0420759680567735 0.638523956723338 1 26.3 26 3 increased pheochromocytoma incidence 0.0117389836508144 0.0420759680567735 0.638523956723338 1 26.3 26 3 abnormal posterior semicircular canal morphology 0.0117389836508144 0.0420759680567735 0.638523956723338 1 26.3 26 3 abnormal NMDA-mediated synaptic currents 0.0117389836508144 0.0420759680567735 0.638523956723338 1 26.3 26 3 decreased circulating bicarbonate level 0.0117389836508144 0.0420759680567735 0.638523956723338 1 26.3 26 3 genetic imprinting 0.0117389836508144 0.0420759680567735 0.638523956723338 1 26.3 26 3 abnormal abdominal wall morphology 0.0117389836508144 0.0420759680567735 0.638523956723338 1 26.3 26 3 premature bone ossification 0.0117389836508144 0.0420759680567735 0.638523956723338 1 26.3 26 3 premature neuronal precursor differentiation 0.0117389836508144 0.0420759680567735 0.638523956723338 1 26.3 26 3 abnormal thymus physiology 0.0117389836508144 0.0420759680567735 0.638523956723338 1 26.3 26 3 impaired febrile response 0.0117389836508144 0.0420759680567735 0.638523956723338 1 26.3 26 3 decreased cellular sensitivity to ionizing radiation 0.0117389836508144 0.0420759680567735 0.638523956723338 1 26.3 26 3 decreased muscle weight 0.0117389836508144 0.0420759680567735 0.638523956723338 1 26.3 26 3 decreased vestibular hair cell number 0.0117389836508144 0.0420759680567735 0.638523956723338 1 26.3 26 3 small scapula 0.0117389836508144 0.0420759680567735 0.638523956723338 1 26.3 26 3 increased neuronal precursor cell number 0.0117389836508144 0.0420759680567735 0.638523956723338 1 26.3 26 3 abnormal CNS synapse formation 0.0117389836508144 0.0420759680567735 0.638523956723338 1 26.3 26 3 abnormal posterior eye segment morphology 0.0117389836508144 0.0420759680567735 0.638523956723338 1 26.3 26 3 hemothorax 0.0117389836508144 0.0420759680567735 0.638523956723338 1 26.3 26 3 abnormal inguinal fat pad morphology 0.0117389836508144 0.0420759680567735 0.638523956723338 1 26.3 26 3 abnormal leukopoiesis 0.0117389836508144 0.0420759680567735 0.638523956723338 1 26.3 26 3 decreased pulmonary ventilation 0.0117389836508144 0.0420759680567735 0.638523956723338 1 26.3 26 3 absent cervical lymph nodes 0.0117389836508144 0.0420759680567735 0.638523956723338 1 26.3 26 3 abnormal liver vasculature morphology 0.0117389836508144 0.0420759680567735 0.638523956723338 1 26.3 26 3 abnormal hyoid bone lesser horn morphology 0.0117389836508144 0.0420759680567735 0.638523956723338 1 26.3 26 3 abnormal hippocampus granule cell morphology 0.0117389836508144 0.0420759680567735 0.638523956723338 1 26.3 26 3 abnormal cerebellar layer morphology 0.0117389836508144 0.0420759680567735 0.638523956723338 1 26.3 26 3 axonal spheroids 0.0117389836508144 0.0420759680567735 0.638523956723338 1 26.3 26 3 retropulsion 0.0117389836508144 0.0420759680567735 0.638523956723338 1 26.3 26 3 fusion of atlas and occipital bones 0.0117389836508144 0.0420759680567735 0.638523956723338 1 26.3 26 3 decreased effector memory CD4-positive, alpha-beta T cell number 0.0117389836508144 0.0420759680567735 0.638523956723338 1 26.3 26 3 abnormal ureteric bud invasion 0.0117389836508144 0.0420759680567735 0.638523956723338 1 26.3 26 3 reduced AMPA-mediated synaptic currents 0.0117389836508144 0.0420759680567735 0.638523956723338 1 26.3 26 3 abnormal infrahyoid muscle connection 0.0117389836508144 0.0420759680567735 0.638523956723338 1 26.3 26 3 symmetric azygos veins 0.0117389836508144 0.0420759680567735 0.638523956723338 1 26.3 26 3 increased cardiac muscle glycogen level 0.0117389836508144 0.0420759680567735 0.638523956723338 1 26.3 26 3 decreased fatty acid oxidation 0.0117389836508144 0.0420759680567735 0.638523956723338 1 26.3 26 3 cerebellum atrophy 0.0117389836508144 0.0420759680567735 0.638523956723338 1 26.3 26 3 decreased platelet dense granule number 0.0117389836508144 0.0420759680567735 0.638523956723338 1 26.3 26 3 seizures 2.34383541151325e-23 2.42928774422467e-21 0.63292286938366 0.991228070175439 26.3 26 3 short limbs 1.16460406233265e-17 6.73709908151736e-16 0.631184600898932 0.988505747126437 26.3 26 3 increased embryonic tissue cell apoptosis 9.02768919347468e-16 4.36046152791617e-14 0.630337752149962 0.987179487179487 26.3 26 3 abnormal kidney development 5.17687979022288e-12 1.49738238118365e-10 0.627881890777949 0.983333333333333 26.3 26 3 abnormal vitelline vasculature morphology 5.34220211635991e-22 5.11104914017126e-20 0.627419192258585 0.982608695652174 26.3 26 3 abnormal axon morphology 1.51690597689968e-20 1.27908597204676e-18 0.62669943900624 0.981481481481482 26.3 26 3 abnormal chondrocyte morphology 9.09712798151828e-11 2.05719144127516e-09 0.62669943900624 0.981481481481482 26.3 26 3 abnormal neuronal precursor proliferation 9.09712798151828e-11 2.05719144127516e-09 0.62669943900624 0.981481481481482 26.3 26 3 distended pericardium 2.35889209160106e-10 5.19269387421029e-09 0.626244649863274 0.980769230769231 26.3 26 3 abnormal placenta vasculature 2.35889209160106e-10 5.19269387421029e-09 0.626244649863274 0.980769230769231 26.3 26 3 abnormal dendritic spine morphology 3.79641188885187e-10 8.16210034045576e-09 0.626003879140528 0.980392156862745 26.3 26 3 increased B cell derived lymphoma incidence 6.10763635106144e-10 1.25559879531118e-08 0.625753477588872 0.98 26.3 26 3 abnormal craniofacial development 9.82203454452721e-10 1.9863667422367e-08 0.625492855565719 0.979591836734694 26.3 26 3 pulmonary hypoplasia 2.53697884847887e-09 4.74491344781293e-08 0.624938340622842 0.978723404255319 26.3 26 3 abnormal forelimb morphology 4.074643975538e-09 7.31817825931464e-08 0.624643001142396 0.978260869565217 26.3 26 3 embryonic lethality between implantation and placentation, complete penetrance 4.074643975538e-09 7.31817825931464e-08 0.624643001142396 0.978260869565217 26.3 26 3 abnormal myocardial trabeculae morphology 6.5412733190004e-09 1.12604964574488e-07 0.62433453546282 0.977777777777778 26.3 26 3 lethality at weaning, complete penetrance 6.5412733190004e-09 1.12604964574488e-07 0.62433453546282 0.977777777777778 26.3 26 3 increased startle reflex 1.27012859482226e-16 6.51431933942346e-15 0.624175103763263 0.97752808988764 26.3 26 3 omphalocele 1.04960621731434e-08 1.73481426283682e-07 0.62401204861599 0.977272727272727 26.3 26 3 abnormal amino acid level 1.04960621731434e-08 1.73481426283682e-07 0.62401204861599 0.977272727272727 26.3 26 3 abnormal axon guidance 1.68334476615119e-08 2.69281035742835e-07 0.623674562380935 0.976744186046512 26.3 26 3 delayed endochondral bone ossification 1.68334476615119e-08 2.69281035742835e-07 0.623674562380935 0.976744186046512 26.3 26 3 abnormal nervous system electrophysiology 1.34847432712744e-15 6.21172201616574e-14 0.623321005372783 0.976190476190476 26.3 26 3 thick ventricular wall 4.32290332139824e-08 6.62728635864756e-07 0.622950201681306 0.975609756097561 26.3 26 3 decreased heart weight 5.54528032758401e-15 2.37825600256297e-13 0.62275793310054 0.975308641975309 26.3 26 3 perinatal lethality 6.9216598675026e-08 1.03409182705182e-06 0.622560857805255 0.975 26.3 26 3 abnormal excitatory postsynaptic currents 2.27389691126607e-14 9.05010970683895e-13 0.622151547576586 0.974358974358974 26.3 26 3 abnormal cell morphology 2.09588025749229e-20 1.68177488403615e-18 0.621720694704303 0.973684210526316 26.3 26 3 persistence of hyaloid vascular system 1.77128425058892e-07 2.46149138175416e-06 0.621720694704303 0.973684210526316 26.3 26 3 abnormal limb morphology 9.29597472165208e-14 3.4005495764867e-12 0.621496651210716 0.973333333333333 26.3 26 3 kidney cysts 1.48533802828897e-13 5.31622783506304e-12 0.621266552487573 0.972972972972973 26.3 26 3 decreased width of hypertrophic chondrocyte zone 2.83077576120696e-07 3.74550782234165e-06 0.621266552487573 0.972972972972973 26.3 26 3 abnormal fertility/fecundity 2.37243104995386e-13 8.36556067490099e-12 0.621030149689822 0.972602739726027 26.3 26 3 abnormal digit morphology 3.7878751681355e-13 1.29472596181895e-11 0.62078718014769 0.972222222222222 26.3 26 3 reduced long term depression 4.5208738680876e-07 5.78183740198864e-06 0.62078718014769 0.972222222222222 26.3 26 3 abnormal limb bone morphology 4.5208738680876e-07 5.78183740198864e-06 0.62078718014769 0.972222222222222 26.3 26 3 renal hypoplasia 4.5208738680876e-07 5.78183740198864e-06 0.62078718014769 0.972222222222222 26.3 26 3 increased carcinoma incidence 7.21478286476683e-07 8.7332225674489e-06 0.620280415102672 0.971428571428571 26.3 26 3 decreased bone volume 7.21478286476683e-07 8.7332225674489e-06 0.620280415102672 0.971428571428571 26.3 26 3 decreased spleen weight 1.53801303924029e-12 4.84279422165852e-11 0.620016015948749 0.971014492753623 26.3 26 3 abnormal craniofacial morphology 3.61386386385458e-18 2.27581933198437e-16 0.619926171576057 0.970873786407767 26.3 26 3 impaired synaptic plasticity 1.15051164412857e-06 1.33421804884374e-05 0.619743840349123 0.970588235294118 26.3 26 3 abnormal nervous system development 1.15051164412857e-06 1.33421804884374e-05 0.619743840349123 0.970588235294118 26.3 26 3 abnormal vascular development 6.22100136387621e-12 1.76854181630195e-10 0.61917474591354 0.96969696969697 26.3 26 3 decreased brown adipose tissue amount 1.83318846215628e-06 2.04029364635962e-05 0.61917474591354 0.96969696969697 26.3 26 3 abnormal locomotor coordination 1.83318846215628e-06 2.04029364635962e-05 0.61917474591354 0.96969696969697 26.3 26 3 single kidney 1.83318846215628e-06 2.04029364635962e-05 0.61917474591354 0.96969696969697 26.3 26 3 abnormal QRS complex 1.83318846215628e-06 2.04029364635962e-05 0.61917474591354 0.96969696969697 26.3 26 3 abnormal brain morphology 2.28614144303177e-27 3.15932046641196e-25 0.618694020179135 0.968944099378882 26.3 26 3 kidney cortex cysts 2.91844415545975e-06 3.08264536590493e-05 0.618570083075734 0.96875 26.3 26 3 abnormal embryonic hematopoiesis 2.91844415545975e-06 3.08264536590493e-05 0.618570083075734 0.96875 26.3 26 3 pancreatic islet hyperplasia 2.91844415545975e-06 3.08264536590493e-05 0.618570083075734 0.96875 26.3 26 3 abnormal auditory brainstem response waveform shape 2.91844415545975e-06 3.08264536590493e-05 0.618570083075734 0.96875 26.3 26 3 increased fibroblast apoptosis 2.91844415545975e-06 3.08264536590493e-05 0.618570083075734 0.96875 26.3 26 3 abnormal podocyte morphology 4.64196473789523e-06 4.75180546728987e-05 0.617926409732263 0.967741935483871 26.3 26 3 preaxial polydactyly 4.64196473789523e-06 4.75180546728987e-05 0.617926409732263 0.967741935483871 26.3 26 3 abnormal long bone morphology 6.32789289560402e-11 1.47108725026308e-09 0.617588745027491 0.967213114754098 26.3 26 3 perinatal lethality, complete penetrance 2.39078470284261e-35 5.37742708916752e-33 0.617539601338064 0.967136150234742 26.3 26 3 intracranial hemorrhage 1.00477073190942e-10 2.25168215822044e-09 0.61723982483256 0.966666666666667 26.3 26 3 muscular ventricular septal defect 1.00477073190942e-10 2.25168215822044e-09 0.61723982483256 0.966666666666667 26.3 26 3 abnormal heart tube morphology 7.37622926652896e-06 7.29557467216333e-05 0.61723982483256 0.966666666666667 26.3 26 3 abnormal synaptic transmission 7.37622926652896e-06 7.29557467216333e-05 0.61723982483256 0.966666666666667 26.3 26 3 abnormal brain vasculature morphology 7.37622926652896e-06 7.29557467216333e-05 0.61723982483256 0.966666666666667 26.3 26 3 small kidney 3.81790955373349e-15 1.65166087215862e-13 0.616756094562316 0.965909090909091 26.3 26 3 abnormal embryonic neuroepithelium morphology 2.52902743311854e-10 5.51838222796699e-09 0.61650588925012 0.96551724137931 26.3 26 3 abnormal middle ear morphology 1.17090784573328e-05 0.000110327017661422 0.61650588925012 0.96551724137931 26.3 26 3 lordosis 1.17090784573328e-05 0.000110327017661422 0.61650588925012 0.96551724137931 26.3 26 3 abnormal spinal nerve morphology 1.17090784573328e-05 0.000110327017661422 0.61650588925012 0.96551724137931 26.3 26 3 increased mortality induced by gamma-irradiation 1.17090784573328e-05 0.000110327017661422 0.61650588925012 0.96551724137931 26.3 26 3 short sternum 1.17090784573328e-05 0.000110327017661422 0.61650588925012 0.96551724137931 26.3 26 3 blood in lymph vessels 1.17090784573328e-05 0.000110327017661422 0.61650588925012 0.96551724137931 26.3 26 3 abnormal craniofacial bone morphology 4.0088176798568e-10 8.48675232225003e-09 0.616119607364625 0.964912280701754 26.3 26 3 decreased brain weight 4.0088176798568e-10 8.48675232225003e-09 0.616119607364625 0.964912280701754 26.3 26 3 abnormal facial morphology 4.0088176798568e-10 8.48675232225003e-09 0.616119607364625 0.964912280701754 26.3 26 3 abnormal lung development 1.52145125954473e-14 6.15383741157321e-13 0.615987817074279 0.964705882352941 26.3 26 3 short mandible 6.3505899883787e-10 1.30017223013103e-08 0.615719529697505 0.964285714285714 26.3 26 3 absent corpus callosum 1.85668295367836e-05 0.000167640611516332 0.615719529697505 0.964285714285714 26.3 26 3 straub tail 1.85668295367836e-05 0.000167640611516332 0.615719529697505 0.964285714285714 26.3 26 3 hypoxia 1.85668295367836e-05 0.000167640611516332 0.615719529697505 0.964285714285714 26.3 26 3 abnormal brainstem morphology 1.85668295367836e-05 0.000167640611516332 0.615719529697505 0.964285714285714 26.3 26 3 increased triglyceride level 1.85668295367836e-05 0.000167640611516332 0.615719529697505 0.964285714285714 26.3 26 3 prolonged QRS complex duration 1.85668295367836e-05 0.000167640611516332 0.615719529697505 0.964285714285714 26.3 26 3 subcutaneous edema 1.85668295367836e-05 0.000167640611516332 0.615719529697505 0.964285714285714 26.3 26 3 pale yolk sac 3.81614339224748e-14 1.49490656507332e-12 0.615444777564664 0.963855421686747 26.3 26 3 abnormal head morphology 1.00539749899966e-09 2.0168760312594e-08 0.615304903751581 0.963636363636364 26.3 26 3 abnormal contextual conditioning behavior 1.00539749899966e-09 2.0168760312594e-08 0.615304903751581 0.963636363636364 26.3 26 3 abnormal excitatory postsynaptic potential 6.03974897216078e-14 2.27634478306817e-12 0.61516332416029 0.963414634146341 26.3 26 3 short snout 5.9753859545294e-18 3.49735824985691e-16 0.614874921289141 0.962962962962963 26.3 26 3 impaired limb coordination 1.59066215933185e-09 3.06726521033952e-08 0.614874921289141 0.962962962962963 26.3 26 3 abnormal trigeminal nerve morphology 2.94067818081846e-05 0.000249656552040475 0.614874921289141 0.962962962962963 26.3 26 3 thin epidermis 2.94067818081846e-05 0.000249656552040475 0.614874921289141 0.962962962962963 26.3 26 3 abnormal brain commissure morphology 2.94067818081846e-05 0.000249656552040475 0.614874921289141 0.962962962962963 26.3 26 3 abnormal nervous system morphology 2.38775802178078e-13 8.36556067490099e-12 0.614276211531313 0.962025316455696 26.3 26 3 abnormal erythropoiesis 2.36168922329564e-17 1.30548932065509e-15 0.61419923456245 0.961904761904762 26.3 26 3 decreased kidney weight 3.97344068201226e-09 7.18831541564036e-08 0.61396534300321 0.961538461538462 26.3 26 3 abnormal brain wave pattern 3.97344068201226e-09 7.18831541564036e-08 0.61396534300321 0.961538461538462 26.3 26 3 abnormal kidney cortex morphology 4.65175175442699e-05 0.000377931741575603 0.61396534300321 0.961538461538462 26.3 26 3 abnormal ureter morphology 4.65175175442699e-05 0.000377931741575603 0.61396534300321 0.961538461538462 26.3 26 3 no spontaneous movement 4.65175175442699e-05 0.000377931741575603 0.61396534300321 0.961538461538462 26.3 26 3 abnormal Mullerian duct morphology 4.65175175442699e-05 0.000377931741575603 0.61396534300321 0.961538461538462 26.3 26 3 increased thymocyte apoptosis 4.65175175442699e-05 0.000377931741575603 0.61396534300321 0.961538461538462 26.3 26 3 lethality throughout fetal growth and development, incomplete penetrance 1.53940503697698e-28 2.47049679321305e-26 0.613553746125219 0.960893854748603 26.3 26 3 impaired balance 9.30235503669044e-17 4.92332088378031e-15 0.613483801557717 0.96078431372549 26.3 26 3 distended abdomen 6.27326356751956e-09 1.09506969292666e-07 0.613483801557717 0.96078431372549 26.3 26 3 small lung 6.27326356751956e-09 1.09506969292666e-07 0.613483801557717 0.96078431372549 26.3 26 3 failure of chorioallantoic fusion 6.27326356751956e-09 1.09506969292666e-07 0.613483801557717 0.96078431372549 26.3 26 3 abnormal interventricular septum morphology 9.89675911877051e-09 1.64670155905964e-07 0.612982998454405 0.96 26.3 26 3 abnormal hindlimb morphology 9.89675911877051e-09 1.64670155905964e-07 0.612982998454405 0.96 26.3 26 3 spontaneous skin ulceration 7.34861475835965e-05 0.000567691900975765 0.612982998454405 0.96 26.3 26 3 diaphragmatic hernia 7.34861475835965e-05 0.000567691900975765 0.612982998454405 0.96 26.3 26 3 abnormal cochlear outer hair cell morphology 7.34861475835965e-05 0.000567691900975765 0.612982998454405 0.96 26.3 26 3 abnormal vertebrae development 7.34861475835965e-05 0.000567691900975765 0.612982998454405 0.96 26.3 26 3 abnormal neuron morphology 3.6508371773466e-16 1.81629149572993e-14 0.612725008976941 0.95959595959596 26.3 26 3 abnormal angiogenesis 2.33669658960229e-12 7.17596637856257e-11 0.61263785036969 0.959459459459459 26.3 26 3 absent kidney 1.56010044966546e-08 2.51181221264907e-07 0.6124617544081 0.959183673469388 26.3 26 3 astrocytosis 3.68149045923736e-12 1.09673143920395e-10 0.612283246173064 0.958904109589041 26.3 26 3 abnormal malleus morphology 0.000115923225390038 0.000846869377849395 0.611918791859866 0.958333333333333 26.3 26 3 abnormal adrenal gland morphology 0.000115923225390038 0.000846869377849395 0.611918791859866 0.958333333333333 26.3 26 3 abnormal startle reflex 0.000115923225390038 0.000846869377849395 0.611918791859866 0.958333333333333 26.3 26 3 hemolytic anemia 0.000115923225390038 0.000846869377849395 0.611918791859866 0.958333333333333 26.3 26 3 blindness 0.000115923225390038 0.000846869377849395 0.611918791859866 0.958333333333333 26.3 26 3 abnormal cardiac muscle contractility 0.000115923225390038 0.000846869377849395 0.611918791859866 0.958333333333333 26.3 26 3 increased body temperature 0.000115923225390038 0.000846869377849395 0.611918791859866 0.958333333333333 26.3 26 3 abnormal truncus arteriosus septation 0.000115923225390038 0.000846869377849395 0.611918791859866 0.958333333333333 26.3 26 3 abnormal skeletal muscle fiber morphology 9.122542377493e-12 2.50743913414518e-10 0.611544071227986 0.957746478873239 26.3 26 3 domed cranium 1.43474004582316e-11 3.85828742052443e-10 0.611158644292338 0.957142857142857 26.3 26 3 abnormal cell cycle 3.45679673050696e-18 2.26283733345686e-16 0.610762045561454 0.956521739130435 26.3 26 3 abnormal nervous system physiology 3.45679673050696e-18 2.26283733345686e-16 0.610762045561454 0.956521739130435 26.3 26 3 microcephaly 2.25507958219684e-11 5.6376989554921e-10 0.610762045561454 0.956521739130435 26.3 26 3 abnormal cell death 6.08071188751729e-08 9.16713383042379e-07 0.610762045561454 0.956521739130435 26.3 26 3 fragile skeleton 0.000182583827132461 0.00123585651698502 0.610762045561454 0.956521739130435 26.3 26 3 abnormal pulmonary artery morphology 0.000182583827132461 0.00123585651698502 0.610762045561454 0.956521739130435 26.3 26 3 abnormal postnatal growth 0.000182583827132461 0.00123585651698502 0.610762045561454 0.956521739130435 26.3 26 3 abnormal nasal cavity morphology 0.000182583827132461 0.00123585651698502 0.610762045561454 0.956521739130435 26.3 26 3 abnormal Wolffian duct morphology 0.000182583827132461 0.00123585651698502 0.610762045561454 0.956521739130435 26.3 26 3 abnormal B cell morphology 0.000182583827132461 0.00123585651698502 0.610762045561454 0.956521739130435 26.3 26 3 abnormal ulna morphology 0.000182583827132461 0.00123585651698502 0.610762045561454 0.956521739130435 26.3 26 3 abnormal palatal shelf fusion at midline 0.000182583827132461 0.00123585651698502 0.610762045561454 0.956521739130435 26.3 26 3 abnormal basicranium morphology 0.000182583827132461 0.00123585651698502 0.610762045561454 0.956521739130435 26.3 26 3 abnormal hematopoietic stem cell physiology 0.000182583827132461 0.00123585651698502 0.610762045561454 0.956521739130435 26.3 26 3 decreased embryo size 1.13619137853471e-71 8.07507444030029e-69 0.610471649001183 0.956066945606695 26.3 26 3 abnormal inhibitory postsynaptic currents 3.542210299447e-11 8.54042327347353e-10 0.610353782162015 0.955882352941177 26.3 26 3 oxidative stress 2.15479470634335e-14 8.64524489036949e-13 0.610145114202301 0.955555555555556 26.3 26 3 abnormal cartilage development 9.55240225372172e-08 1.40601187018537e-06 0.610145114202301 0.955555555555556 26.3 26 3 irregular heartbeat 9.55240225372172e-08 1.40601187018537e-06 0.610145114202301 0.955555555555556 26.3 26 3 abnormal cranium morphology 8.42331104684325e-21 7.61926771964458e-19 0.609933331795428 0.955223880597015 26.3 26 3 muscular atrophy 1.49918542917253e-07 2.11887713356061e-06 0.609500140508641 0.954545454545455 26.3 26 3 abnormal basisphenoid bone morphology 0.000287095079416391 0.00182180869910274 0.609500140508641 0.954545454545455 26.3 26 3 abnormal facial nerve morphology 0.000287095079416391 0.00182180869910274 0.609500140508641 0.954545454545455 26.3 26 3 abnormal tail movements 0.000287095079416391 0.00182180869910274 0.609500140508641 0.954545454545455 26.3 26 3 intracerebral hemorrhage 0.000287095079416391 0.00182180869910274 0.609500140508641 0.954545454545455 26.3 26 3 abnormal oogenesis 0.000287095079416391 0.00182180869910274 0.609500140508641 0.954545454545455 26.3 26 3 aphakia 0.000287095079416391 0.00182180869910274 0.609500140508641 0.954545454545455 26.3 26 3 abnormal lysosome physiology 0.000287095079416391 0.00182180869910274 0.609500140508641 0.954545454545455 26.3 26 3 abnormal vascular branching morphogenesis 0.000287095079416391 0.00182180869910274 0.609500140508641 0.954545454545455 26.3 26 3 abnormal cochlear sensory epithelium morphology 0.000287095079416391 0.00182180869910274 0.609500140508641 0.954545454545455 26.3 26 3 abnormal channel response 0.000287095079416391 0.00182180869910274 0.609500140508641 0.954545454545455 26.3 26 3 abnormal basement membrane morphology 0.000287095079416391 0.00182180869910274 0.609500140508641 0.954545454545455 26.3 26 3 abnormal mesenteric lymph node morphology 0.000287095079416391 0.00182180869910274 0.609500140508641 0.954545454545455 26.3 26 3 abnormal temporal bone morphology 0.000287095079416391 0.00182180869910274 0.609500140508641 0.954545454545455 26.3 26 3 abnormal cerebral cortex pyramidal cell morphology 0.000287095079416391 0.00182180869910274 0.609500140508641 0.954545454545455 26.3 26 3 increased circulating creatine kinase level 0.000287095079416391 0.00182180869910274 0.609500140508641 0.954545454545455 26.3 26 3 increased mammary gland tumor incidence 0.000287095079416391 0.00182180869910274 0.609500140508641 0.954545454545455 26.3 26 3 increased adenoma incidence 0.000287095079416391 0.00182180869910274 0.609500140508641 0.954545454545455 26.3 26 3 impaired coordination 3.0568988606156e-51 1.38255198468751e-48 0.608996837337288 0.953757225433526 26.3 26 3 kidney failure 2.3505229837824e-07 3.16050049846418e-06 0.608825168038532 0.953488372093023 26.3 26 3 gliosis 3.35279576369703e-10 7.28391219405796e-09 0.608118054022227 0.952380952380952 26.3 26 3 abnormal cartilage morphology 3.68146464526901e-07 4.79457764665271e-06 0.608118054022227 0.952380952380952 26.3 26 3 abnormal reproductive system morphology 3.68146464526901e-07 4.79457764665271e-06 0.608118054022227 0.952380952380952 26.3 26 3 spina bifida 3.68146464526901e-07 4.79457764665271e-06 0.608118054022227 0.952380952380952 26.3 26 3 small ears 0.000450607390147405 0.00272390251030783 0.608118054022227 0.952380952380952 26.3 26 3 abnormal scapula morphology 0.000450607390147405 0.00272390251030783 0.608118054022227 0.952380952380952 26.3 26 3 abnormal erythrocyte physiology 0.000450607390147405 0.00272390251030783 0.608118054022227 0.952380952380952 26.3 26 3 abnormal stapes morphology 0.000450607390147405 0.00272390251030783 0.608118054022227 0.952380952380952 26.3 26 3 abnormal clavicle morphology 0.000450607390147405 0.00272390251030783 0.608118054022227 0.952380952380952 26.3 26 3 vascular ring 0.000450607390147405 0.00272390251030783 0.608118054022227 0.952380952380952 26.3 26 3 increased muscle cell glucose uptake 0.000450607390147405 0.00272390251030783 0.608118054022227 0.952380952380952 26.3 26 3 pericardial effusion 5.24426947327132e-10 1.09164186734413e-08 0.607627636236725 0.951612903225806 26.3 26 3 short humerus 5.75974125165375e-07 7.16367818174435e-06 0.607376446639273 0.951219512195122 26.3 26 3 abnormal cell differentiation 5.75974125165375e-07 7.16367818174435e-06 0.607376446639273 0.951219512195122 26.3 26 3 palatal shelves fail to meet at midline 5.75974125165375e-07 7.16367818174435e-06 0.607376446639273 0.951219512195122 26.3 26 3 abnormal neural tube morphology 4.45548949511783e-24 4.71618302940664e-22 0.606991909477742 0.950617283950617 26.3 26 3 increased circulating alkaline phosphatase level 4.45548949511783e-24 4.71618302940664e-22 0.606991909477742 0.950617283950617 26.3 26 3 ataxia 1.088817657457e-29 1.80562261528286e-27 0.606913859855846 0.95049504950495 26.3 26 3 abnormal vascular regression 0.000705844466506561 0.00396340431249452 0.606597758887172 0.95 26.3 26 3 increased mammary adenocarcinoma incidence 0.000705844466506561 0.00396340431249452 0.606597758887172 0.95 26.3 26 3 anencephaly 0.000705844466506561 0.00396340431249452 0.606597758887172 0.95 26.3 26 3 abnormal dopamine level 0.000705844466506561 0.00396340431249452 0.606597758887172 0.95 26.3 26 3 abnormal hearing physiology 0.000705844466506561 0.00396340431249452 0.606597758887172 0.95 26.3 26 3 decreased paired-pulse facilitation 0.000705844466506561 0.00396340431249452 0.606597758887172 0.95 26.3 26 3 abnormal hyoid bone morphology 0.000705844466506561 0.00396340431249452 0.606597758887172 0.95 26.3 26 3 spleen atrophy 0.000705844466506561 0.00396340431249452 0.606597758887172 0.95 26.3 26 3 abnormal male reproductive system physiology 0.000705844466506561 0.00396340431249452 0.606597758887172 0.95 26.3 26 3 abnormal optic stalk morphology 0.000705844466506561 0.00396340431249452 0.606597758887172 0.95 26.3 26 3 abnormal postnatal subventricular zone morphology 0.000705844466506561 0.00396340431249452 0.606597758887172 0.95 26.3 26 3 dilated vasculature 0.000705844466506561 0.00396340431249452 0.606597758887172 0.95 26.3 26 3 kidney atrophy 0.000705844466506561 0.00396340431249452 0.606597758887172 0.95 26.3 26 3 abnormal incus morphology 0.000705844466506561 0.00396340431249452 0.606597758887172 0.95 26.3 26 3 decreased circulating VLDL cholesterol level 0.000705844466506561 0.00396340431249452 0.606597758887172 0.95 26.3 26 3 increased skin tumor incidence 0.000705844466506561 0.00396340431249452 0.606597758887172 0.95 26.3 26 3 abnormal heart electrocardiography waveform feature 0.000705844466506561 0.00396340431249452 0.606597758887172 0.95 26.3 26 3 absent ductus venosus valve 0.000705844466506561 0.00396340431249452 0.606597758887172 0.95 26.3 26 3 abnormal incisor morphology 1.2800079407827e-09 2.51701166221105e-08 0.606597758887171 0.95 26.3 26 3 reduced fertility 1.08756708619871e-20 9.32870043765273e-19 0.606368074010652 0.949640287769784 26.3 26 3 abnormal visceral yolk sac morphology 2.97246801929263e-12 9.01709048535416e-11 0.606193629800638 0.949367088607595 26.3 26 3 cardiac hypertrophy 7.06409484850749e-15 3.00374973259186e-13 0.605946203829291 0.948979591836735 26.3 26 3 decreased startle reflex 1.70114452210161e-17 9.61726590619943e-16 0.605779138429834 0.948717948717949 26.3 26 3 abnormal heart ventricle morphology 4.63505582346373e-12 1.37258349534119e-10 0.605779138429834 0.948717948717949 26.3 26 3 cochlear ganglion degeneration 3.11383055367253e-09 5.75885018755422e-08 0.605496855513511 0.948275862068966 26.3 26 3 incomplete embryo turning 4.85024915417726e-09 8.5871848904028e-08 0.604917432685268 0.947368421052632 26.3 26 3 increased hepatocellular carcinoma incidence 4.85024915417726e-09 8.5871848904028e-08 0.604917432685268 0.947368421052632 26.3 26 3 abnormal circulating amino acid level 4.85024915417726e-09 8.5871848904028e-08 0.604917432685268 0.947368421052632 26.3 26 3 decreased hair follicle number 2.19016229523315e-06 2.40531068847349e-05 0.604917432685268 0.947368421052632 26.3 26 3 incomplete somite formation 2.19016229523315e-06 2.40531068847349e-05 0.604917432685268 0.947368421052632 26.3 26 3 abnormal stationary movement 0.00110325720676745 0.00583904745071068 0.604917432685268 0.947368421052632 26.3 26 3 stereotypic behavior 0.00110325720676745 0.00583904745071068 0.604917432685268 0.947368421052632 26.3 26 3 unresponsive to tactile stimuli 0.00110325720676745 0.00583904745071068 0.604917432685268 0.947368421052632 26.3 26 3 abnormal long term depression 0.00110325720676745 0.00583904745071068 0.604917432685268 0.947368421052632 26.3 26 3 abnormal neurotransmitter level 0.00110325720676745 0.00583904745071068 0.604917432685268 0.947368421052632 26.3 26 3 abnormal metatarsal bone morphology 0.00110325720676745 0.00583904745071068 0.604917432685268 0.947368421052632 26.3 26 3 abnormal cochlear inner hair cell morphology 0.00110325720676745 0.00583904745071068 0.604917432685268 0.947368421052632 26.3 26 3 eyelids fail to open 0.00110325720676745 0.00583904745071068 0.604917432685268 0.947368421052632 26.3 26 3 abnormal behavioral response to xenobiotic 0.00110325720676745 0.00583904745071068 0.604917432685268 0.947368421052632 26.3 26 3 delayed bone ossification 1.75020383639573e-11 4.55877700841295e-10 0.604469345698094 0.946666666666667 26.3 26 3 abnormal neurocranium morphology 1.75020383639573e-11 4.55877700841295e-10 0.604469345698094 0.946666666666667 26.3 26 3 increased circulating phosphate level 3.40975907384983e-06 3.55630008226476e-05 0.604009148251807 0.945945945945946 26.3 26 3 abnormal chromosome morphology 3.40975907384983e-06 3.55630008226476e-05 0.604009148251807 0.945945945945946 26.3 26 3 abnormal calcium ion homeostasis 3.40975907384983e-06 3.55630008226476e-05 0.604009148251807 0.945945945945946 26.3 26 3 decreased cell proliferation 2.08319713789624e-26 2.72734362132468e-24 0.604009148251807 0.945945945945946 26.3 26 3 abnormal learning/memory/conditioning 1.17352496050898e-08 1.92048903899085e-07 0.603695377265702 0.945454545454545 26.3 26 3 limb grasping 7.83224913594532e-26 9.74135986283199e-24 0.603440222837441 0.945054945054945 26.3 26 3 hydrops fetalis 6.56581753425635e-11 1.51929963874071e-09 0.603050403572042 0.944444444444444 26.3 26 3 abnormal cell adhesion 1.82273336737765e-08 2.89715607115138e-07 0.603050403572042 0.944444444444444 26.3 26 3 heart right ventricle hypertrophy 5.30112358083142e-06 5.3822632274768e-05 0.603050403572042 0.944444444444444 26.3 26 3 narrow eye opening 5.30112358083142e-06 5.3822632274768e-05 0.603050403572042 0.944444444444444 26.3 26 3 abnormal heart shape 0.00172031653783429 0.00849064957909287 0.603050403572042 0.944444444444444 26.3 26 3 underdeveloped hair follicles 0.00172031653783429 0.00849064957909287 0.603050403572042 0.944444444444444 26.3 26 3 cortical renal glomerulopathies 0.00172031653783429 0.00849064957909287 0.603050403572042 0.944444444444444 26.3 26 3 abnormal radius morphology 0.00172031653783429 0.00849064957909287 0.603050403572042 0.944444444444444 26.3 26 3 abnormal mammary gland morphology 0.00172031653783429 0.00849064957909287 0.603050403572042 0.944444444444444 26.3 26 3 eye inflammation 0.00172031653783429 0.00849064957909287 0.603050403572042 0.944444444444444 26.3 26 3 abnormal thymus medulla morphology 0.00172031653783429 0.00849064957909287 0.603050403572042 0.944444444444444 26.3 26 3 abnormal bile duct morphology 0.00172031653783429 0.00849064957909287 0.603050403572042 0.944444444444444 26.3 26 3 acidosis 0.00172031653783429 0.00849064957909287 0.603050403572042 0.944444444444444 26.3 26 3 abnormal metacarpal bone morphology 0.00172031653783429 0.00849064957909287 0.603050403572042 0.944444444444444 26.3 26 3 long tibia 0.00172031653783429 0.00849064957909287 0.603050403572042 0.944444444444444 26.3 26 3 absent inner cell mass 0.00172031653783429 0.00849064957909287 0.603050403572042 0.944444444444444 26.3 26 3 abnormal neutrophil morphology 0.00172031653783429 0.00849064957909287 0.603050403572042 0.944444444444444 26.3 26 3 abnormal eye anterior chamber morphology 0.00172031653783429 0.00849064957909287 0.603050403572042 0.944444444444444 26.3 26 3 jerky movement 0.00172031653783429 0.00849064957909287 0.603050403572042 0.944444444444444 26.3 26 3 increased gastrointestinal tumor incidence 0.00172031653783429 0.00849064957909287 0.603050403572042 0.944444444444444 26.3 26 3 primary atelectasis 0.00172031653783429 0.00849064957909287 0.603050403572042 0.944444444444444 26.3 26 3 increased effector memory CD8-positive, alpha-beta T cell number 0.00172031653783429 0.00849064957909287 0.603050403572042 0.944444444444444 26.3 26 3 abnormal aerobic respiration 0.00172031653783429 0.00849064957909287 0.603050403572042 0.944444444444444 26.3 26 3 abnormal hypoglossal nerve topology 0.00172031653783429 0.00849064957909287 0.603050403572042 0.944444444444444 26.3 26 3 increased adipocyte glucose uptake 0.00172031653783429 0.00849064957909287 0.603050403572042 0.944444444444444 26.3 26 3 anophthalmia 3.76065022005293e-13 1.29472596181895e-11 0.602651824323151 0.943820224719101 26.3 26 3 increased circulating bilirubin level 2.82820905836808e-08 4.39698127043162e-07 0.602381091248432 0.943396226415094 26.3 26 3 atrioventricular septal defect 2.82820905836808e-08 4.39698127043162e-07 0.602381091248432 0.943396226415094 26.3 26 3 abnormal suckling behavior 5.83073223198967e-13 1.93385952360991e-11 0.602244186454967 0.943181818181818 26.3 26 3 abnormal liver development 8.22956204538473e-06 8.01214700113288e-05 0.602036873482005 0.942857142857143 26.3 26 3 abnormal dermal layer morphology 8.22956204538473e-06 8.01214700113288e-05 0.602036873482005 0.942857142857143 26.3 26 3 holoprosencephaly 8.22956204538473e-06 8.01214700113288e-05 0.602036873482005 0.942857142857143 26.3 26 3 decreased glycogen level 8.22956204538473e-06 8.01214700113288e-05 0.602036873482005 0.942857142857143 26.3 26 3 increased red blood cell distribution width 8.22956204538473e-06 8.01214700113288e-05 0.602036873482005 0.942857142857143 26.3 26 3 decreased bone mineralization 8.22956204538473e-06 8.01214700113288e-05 0.602036873482005 0.942857142857143 26.3 26 3 abnormal behavior 4.68528596699861e-38 1.29496098254545e-35 0.601774376480269 0.942446043165468 26.3 26 3 abnormal eye morphology 1.16805208525675e-19 9.22390337167037e-18 0.601774376480269 0.942446043165468 26.3 26 3 liver hypoplasia 4.3837037364139e-08 6.64906283190827e-07 0.601686036143146 0.942307692307692 26.3 26 3 eyelids open at birth 4.3837037364139e-08 6.64906283190827e-07 0.601686036143146 0.942307692307692 26.3 26 3 kinked neural tube 4.3837037364139e-08 6.64906283190827e-07 0.601686036143146 0.942307692307692 26.3 26 3 increased circulating creatinine level 1.39883919448754e-12 4.43262738380607e-11 0.601400470867331 0.941860465116279 26.3 26 3 pericardial edema 3.78507294565374e-10 8.16210034045576e-09 0.600963723974907 0.941176470588235 26.3 26 3 enlarged liver sinusoidal spaces 1.27560175505996e-05 0.000119287946079385 0.600963723974907 0.941176470588235 26.3 26 3 hydroureter 0.00267544412802504 0.0122337633611439 0.600963723974907 0.941176470588235 26.3 26 3 abnormal vagus nerve morphology 0.00267544412802504 0.0122337633611439 0.600963723974907 0.941176470588235 26.3 26 3 increased aggression towards mice 0.00267544412802504 0.0122337633611439 0.600963723974907 0.941176470588235 26.3 26 3 abnormal heart rate 0.00267544412802504 0.0122337633611439 0.600963723974907 0.941176470588235 26.3 26 3 abnormal cranial suture morphology 0.00267544412802504 0.0122337633611439 0.600963723974907 0.941176470588235 26.3 26 3 nephrocalcinosis 0.00267544412802504 0.0122337633611439 0.600963723974907 0.941176470588235 26.3 26 3 abnormal duodenum morphology 0.00267544412802504 0.0122337633611439 0.600963723974907 0.941176470588235 26.3 26 3 abnormal embryonic-extraembryonic boundary morphology 0.00267544412802504 0.0122337633611439 0.600963723974907 0.941176470588235 26.3 26 3 increased regulatory T cell number 0.00267544412802504 0.0122337633611439 0.600963723974907 0.941176470588235 26.3 26 3 abnormal tarsal bone morphology 0.00267544412802504 0.0122337633611439 0.600963723974907 0.941176470588235 26.3 26 3 decreased growth hormone level 0.00267544412802504 0.0122337633611439 0.600963723974907 0.941176470588235 26.3 26 3 enhanced behavioral response to cocaine 0.00267544412802504 0.0122337633611439 0.600963723974907 0.941176470588235 26.3 26 3 increased circulating magnesium level 0.00267544412802504 0.0122337633611439 0.600963723974907 0.941176470588235 26.3 26 3 increased trabecular bone mass 0.00267544412802504 0.0122337633611439 0.600963723974907 0.941176470588235 26.3 26 3 increased lung adenocarcinoma incidence 6.7872687938786e-08 1.01706814004657e-06 0.600963723974907 0.941176470588235 26.3 26 3 embryonic lethality during organogenesis, complete penetrance 8.31507669651071e-75 6.89458442752346e-72 0.600896652130713 0.941071428571429 26.3 26 3 hydronephrosis 3.34657478786994e-12 1.0029644319068e-10 0.600516578346949 0.94047619047619 26.3 26 3 abnormal cardiovascular system physiology 1.6015904305619e-18 1.1066544988952e-16 0.600116500679829 0.93984962406015 26.3 26 3 belly spot 1.97399074016635e-05 0.000175055328561989 0.599825535103742 0.939393939393939 26.3 26 3 dilated heart atrium 1.97399074016635e-05 0.000175055328561989 0.599825535103742 0.939393939393939 26.3 26 3 increased osteoblast cell number 1.97399074016635e-05 0.000175055328561989 0.599825535103742 0.939393939393939 26.3 26 3 abnormal middle ear ossicle morphology 1.97399074016635e-05 0.000175055328561989 0.599825535103742 0.939393939393939 26.3 26 3 head tossing 1.97399074016635e-05 0.000175055328561989 0.599825535103742 0.939393939393939 26.3 26 3 decreased sensitivity to xenobiotic induced morbidity/mortality 1.97399074016635e-05 0.000175055328561989 0.599825535103742 0.939393939393939 26.3 26 3 abnormal CNS synaptic transmission 4.63562957355632e-14 1.77401977911098e-12 0.599825535103742 0.939393939393939 26.3 26 3 cleft palate 3.81888056384025e-18 2.37486635063816e-16 0.599530127305119 0.938931297709924 26.3 26 3 prenatal lethality, complete penetrance 4.6961680751274e-37 1.22965453546099e-34 0.599477527715077 0.938848920863309 26.3 26 3 polydactyly 7.15458524268866e-14 2.65627325241613e-12 0.599430653250481 0.938775510204082 26.3 26 3 reduced long term potentiation 1.53876246352466e-15 6.95940296003199e-14 0.59861620942813 0.9375 26.3 26 3 abnormal posture 1.89844977170554e-11 4.83209792693816e-10 0.59861620942813 0.9375 26.3 26 3 overriding aortic valve 2.50158141788164e-07 3.32763838341208e-06 0.59861620942813 0.9375 26.3 26 3 oligodactyly 2.50158141788164e-07 3.32763838341208e-06 0.59861620942813 0.9375 26.3 26 3 abnormal phalanx morphology 2.50158141788164e-07 3.32763838341208e-06 0.59861620942813 0.9375 26.3 26 3 scoliosis 3.04947734744276e-05 0.000257574699550556 0.59861620942813 0.9375 26.3 26 3 polydipsia 3.04947734744276e-05 0.000257574699550556 0.59861620942813 0.9375 26.3 26 3 increased fatty acid level 3.04947734744276e-05 0.000257574699550556 0.59861620942813 0.9375 26.3 26 3 absent mandible 0.00414871403618757 0.0182653560442771 0.59861620942813 0.9375 26.3 26 3 abnormal bone marrow cell number 0.00414871403618757 0.0182653560442771 0.59861620942813 0.9375 26.3 26 3 abnormal hair follicle orientation 0.00414871403618757 0.0182653560442771 0.59861620942813 0.9375 26.3 26 3 delayed hair appearance 0.00414871403618757 0.0182653560442771 0.59861620942813 0.9375 26.3 26 3 poor circulation 0.00414871403618757 0.0182653560442771 0.59861620942813 0.9375 26.3 26 3 white spotting 0.00414871403618757 0.0182653560442771 0.59861620942813 0.9375 26.3 26 3 increased intestinal adenocarcinoma incidence 0.00414871403618757 0.0182653560442771 0.59861620942813 0.9375 26.3 26 3 abnormal epicardium morphology 0.00414871403618757 0.0182653560442771 0.59861620942813 0.9375 26.3 26 3 decreased cochlear coiling 0.00414871403618757 0.0182653560442771 0.59861620942813 0.9375 26.3 26 3 small pancreas 0.00414871403618757 0.0182653560442771 0.59861620942813 0.9375 26.3 26 3 bowed tibia 0.00414871403618757 0.0182653560442771 0.59861620942813 0.9375 26.3 26 3 sepsis 0.00414871403618757 0.0182653560442771 0.59861620942813 0.9375 26.3 26 3 decreased creatinine clearance 0.00414871403618757 0.0182653560442771 0.59861620942813 0.9375 26.3 26 3 abnormal thoracic cage shape 0.00414871403618757 0.0182653560442771 0.59861620942813 0.9375 26.3 26 3 dilated respiratory conducting tubes 0.00414871403618757 0.0182653560442771 0.59861620942813 0.9375 26.3 26 3 embryonic lethality between somite formation and embryo turning, incomplete penetrance 0.00414871403618757 0.0182653560442771 0.59861620942813 0.9375 26.3 26 3 embryonic lethality, complete penetrance 7.44212827885519e-42 2.46830587915364e-39 0.598491106772032 0.93730407523511 26.3 26 3 abnormal hepatocyte morphology 2.37038488232021e-15 1.05291649906634e-13 0.598256680173218 0.936936936936937 26.3 26 3 lethality throughout fetal growth and development, complete penetrance 2.34856381116298e-25 2.84978169769166e-23 0.598196127877654 0.936842105263158 26.3 26 3 abnormal heart development 2.78552575799682e-21 2.61471521623286e-19 0.598111048069963 0.936708860759494 26.3 26 3 abnormal placenta morphology 2.92413553251959e-11 7.1311638599436e-10 0.598111048069963 0.936708860759494 26.3 26 3 abnormal placenta labyrinth morphology 2.92413553251959e-11 7.1311638599436e-10 0.598111048069963 0.936708860759494 26.3 26 3 abnormal myocardium layer morphology 2.92413553251959e-11 7.1311638599436e-10 0.598111048069963 0.936708860759494 26.3 26 3 decreased susceptibility to hepatic steatosis 3.31435066894917e-09 6.06209359486106e-08 0.597982753121857 0.936507936507937 26.3 26 3 increased circulating aspartate transaminase level 3.31435066894917e-09 6.06209359486106e-08 0.597982753121857 0.936507936507937 26.3 26 3 cleft secondary palate 4.0327237599976e-13 1.36481637455701e-11 0.597767108421849 0.936170212765957 26.3 26 3 abnormal tibia morphology 3.85453925473636e-07 4.98086566034114e-06 0.597767108421849 0.936170212765957 26.3 26 3 increased cellular sensitivity to gamma-irradiation 3.85453925473636e-07 4.98086566034114e-06 0.597767108421849 0.936170212765957 26.3 26 3 neuron degeneration 3.85453925473636e-07 4.98086566034114e-06 0.597767108421849 0.936170212765957 26.3 26 3 embryonic lethality before implantation, complete penetrance 5.1145064219965e-17 2.79611752191567e-15 0.597658423493045 0.936 26.3 26 3 small liver 4.50026973791626e-11 1.05607745028931e-09 0.597592933856458 0.935897435897436 26.3 26 3 prenatal lethality 5.10024778727513e-09 8.99777756797652e-08 0.597328862741188 0.935483870967742 26.3 26 3 abnormal cranial ganglia morphology 4.70230649317183e-05 0.000377931741575603 0.597328862741188 0.935483870967742 26.3 26 3 abnormal eyelid morphology 4.70230649317183e-05 0.000377931741575603 0.597328862741188 0.935483870967742 26.3 26 3 increased lung adenoma incidence 4.70230649317183e-05 0.000377931741575603 0.597328862741188 0.935483870967742 26.3 26 3 abnormal postnatal growth/weight/body size 4.70230649317183e-05 0.000377931741575603 0.597328862741188 0.935483870967742 26.3 26 3 abnormal nose morphology 4.70230649317183e-05 0.000377931741575603 0.597328862741188 0.935483870967742 26.3 26 3 abnormal capillary morphology 4.70230649317183e-05 0.000377931741575603 0.597328862741188 0.935483870967742 26.3 26 3 decreased thymus weight 4.70230649317183e-05 0.000377931741575603 0.597328862741188 0.935483870967742 26.3 26 3 pale kidney 4.70230649317183e-05 0.000377931741575603 0.597328862741188 0.935483870967742 26.3 26 3 abnormal T cell proliferation 4.70230649317183e-05 0.000377931741575603 0.597328862741188 0.935483870967742 26.3 26 3 small cranium 4.70230649317183e-05 0.000377931741575603 0.597328862741188 0.935483870967742 26.3 26 3 abnormal gait 5.67879726294257e-40 1.7657510239462e-37 0.597195545284935 0.935275080906149 26.3 26 3 preweaning lethality, complete penetrance 2.35115966381325e-94 2.92425483186773e-91 0.5971061865575 0.935135135135135 26.3 26 3 embryonic lethality during organogenesis, incomplete penetrance 5.7497652807382e-30 9.86382147299053e-28 0.596881089980512 0.934782608695652 26.3 26 3 failure to gastrulate 5.93132975026512e-07 7.35869464029151e-06 0.596881089980512 0.934782608695652 26.3 26 3 double outlet right ventricle 1.32666406335682e-14 5.40996206163951e-13 0.596751361423681 0.934579439252336 26.3 26 3 decreased body length 2.48604669448951e-35 5.37742708916752e-33 0.596577127449542 0.934306569343066 26.3 26 3 abnormal axial skeleton morphology 1.06319355074882e-10 2.37192283182751e-09 0.59651580167575 0.934210526315789 26.3 26 3 ventricular septal defect 4.01430573568529e-18 2.43550866280906e-16 0.596268694881353 0.933823529411765 26.3 26 3 abnormal autopod morphology 9.11441828237773e-07 1.0926320712007e-05 0.595955692941783 0.933333333333333 26.3 26 3 small placenta 9.11441828237773e-07 1.0926320712007e-05 0.595955692941783 0.933333333333333 26.3 26 3 abnormal metabolism 9.11441828237773e-07 1.0926320712007e-05 0.595955692941783 0.933333333333333 26.3 26 3 arrested T cell differentiation 7.23689671285872e-05 0.000562555642913627 0.595955692941783 0.933333333333333 26.3 26 3 abnormal lactation 7.23689671285872e-05 0.000562555642913627 0.595955692941783 0.933333333333333 26.3 26 3 emphysema 7.23689671285872e-05 0.000562555642913627 0.595955692941783 0.933333333333333 26.3 26 3 enhanced paired-pulse facilitation 7.23689671285872e-05 0.000562555642913627 0.595955692941783 0.933333333333333 26.3 26 3 abnormal optic cup morphology 7.23689671285872e-05 0.000562555642913627 0.595955692941783 0.933333333333333 26.3 26 3 abnormal fat pad morphology 7.23689671285872e-05 0.000562555642913627 0.595955692941783 0.933333333333333 26.3 26 3 macrocytosis 0.00641229106823692 0.0265400566260222 0.595955692941783 0.933333333333333 26.3 26 3 vagina atresia 0.00641229106823692 0.0265400566260222 0.595955692941783 0.933333333333333 26.3 26 3 abnormal prostate gland morphology 0.00641229106823692 0.0265400566260222 0.595955692941783 0.933333333333333 26.3 26 3 abnormal bronchus morphology 0.00641229106823692 0.0265400566260222 0.595955692941783 0.933333333333333 26.3 26 3 abnormal lymph node B cell domain morphology 0.00641229106823692 0.0265400566260222 0.595955692941783 0.933333333333333 26.3 26 3 decreased aggression towards males 0.00641229106823692 0.0265400566260222 0.595955692941783 0.933333333333333 26.3 26 3 abnormal rostral migratory stream morphology 0.00641229106823692 0.0265400566260222 0.595955692941783 0.933333333333333 26.3 26 3 abnormal trophectoderm morphology 0.00641229106823692 0.0265400566260222 0.595955692941783 0.933333333333333 26.3 26 3 abnormal zygomatic bone morphology 0.00641229106823692 0.0265400566260222 0.595955692941783 0.933333333333333 26.3 26 3 abnormal neurotransmitter secretion 0.00641229106823692 0.0265400566260222 0.595955692941783 0.933333333333333 26.3 26 3 abnormal energy homeostasis 0.00641229106823692 0.0265400566260222 0.595955692941783 0.933333333333333 26.3 26 3 abnormal cerebral aqueduct morphology 0.00641229106823692 0.0265400566260222 0.595955692941783 0.933333333333333 26.3 26 3 decreased thymocyte apoptosis 0.00641229106823692 0.0265400566260222 0.595955692941783 0.933333333333333 26.3 26 3 abnormal aorta wall morphology 0.00641229106823692 0.0265400566260222 0.595955692941783 0.933333333333333 26.3 26 3 lactation failure 0.00641229106823692 0.0265400566260222 0.595955692941783 0.933333333333333 26.3 26 3 abnormal coronary vessel morphology 0.00641229106823692 0.0265400566260222 0.595955692941783 0.933333333333333 26.3 26 3 abnormal branching involved in lung morphogenesis 0.00641229106823692 0.0265400566260222 0.595955692941783 0.933333333333333 26.3 26 3 heterochrony 0.00641229106823692 0.0265400566260222 0.595955692941783 0.933333333333333 26.3 26 3 decreased brown adipose tissue mass 0.00641229106823692 0.0265400566260222 0.595955692941783 0.933333333333333 26.3 26 3 abnormal intestine morphology 2.50290455012308e-10 5.48544058892614e-09 0.595380446133924 0.932432432432432 26.3 26 3 cyanosis 8.89681092794695e-25 1.00594623560309e-22 0.595290563820196 0.932291666666667 26.3 26 3 hypertension 1.39854695634507e-06 1.59216730155989e-05 0.594988232401293 0.931818181818182 26.3 26 3 abnormal astrocyte morphology 1.39854695634507e-06 1.59216730155989e-05 0.594988232401293 0.931818181818182 26.3 26 3 pallor 1.47483969303924e-22 1.46746549457404e-20 0.594739456833738 0.931428571428571 26.3 26 3 abnormal blood vessel morphology 7.35331268687769e-19 5.37981332606125e-17 0.594487821776901 0.931034482758621 26.3 26 3 abnormal parietal bone morphology 0.00011114646910937 0.000821625087398388 0.594487821776901 0.931034482758621 26.3 26 3 embryonic lethality between implantation and somite formation, complete penetrance 7.11366472455219e-31 1.36117238479412e-28 0.594218212787433 0.930612244897959 26.3 26 3 abnormal testis morphology 3.69455424144128e-15 1.61231643431319e-13 0.594104898864324 0.930434782608696 26.3 26 3 neonatal lethality, complete penetrance 4.31667240637037e-56 2.14754452216926e-53 0.593715258005911 0.929824561403509 26.3 26 3 absent vitelline blood vessels 4.32938304836273e-08 6.62728635864756e-07 0.593715258005911 0.929824561403509 26.3 26 3 circling 1.89117722297529e-11 4.83209792693816e-10 0.59345167742522 0.929411764705882 26.3 26 3 cardiac fibrosis 1.89117722297529e-11 4.83209792693816e-10 0.59345167742522 0.929411764705882 26.3 26 3 abnormal embryo size 8.63209931377393e-15 3.60879782235507e-13 0.59331872084912 0.929203539823009 26.3 26 3 enhanced long term potentiation 6.61689181137709e-08 9.94532832676768e-07 0.592915102671671 0.928571428571429 26.3 26 3 small superior cervical ganglion 0.000170326161336396 0.00117202303270895 0.592915102671671 0.928571428571429 26.3 26 3 abnormal ovulation 0.000170326161336396 0.00117202303270895 0.592915102671671 0.928571428571429 26.3 26 3 abnormal retinal inner nuclear layer morphology 0.000170326161336396 0.00117202303270895 0.592915102671671 0.928571428571429 26.3 26 3 premature aging 0.000170326161336396 0.00117202303270895 0.592915102671671 0.928571428571429 26.3 26 3 enhanced coordination 0.000170326161336396 0.00117202303270895 0.592915102671671 0.928571428571429 26.3 26 3 abnormal hormone level 0.000170326161336396 0.00117202303270895 0.592915102671671 0.928571428571429 26.3 26 3 abnormal interparietal bone morphology 0.00987459793311108 0.0369925637930931 0.592915102671671 0.928571428571429 26.3 26 3 abnormal blood flow velocity 0.00987459793311108 0.0369925637930931 0.592915102671671 0.928571428571429 26.3 26 3 absent atrioventricular cushions 0.00987459793311108 0.0369925637930931 0.592915102671671 0.928571428571429 26.3 26 3 abnormal kidney blood vessel morphology 0.00987459793311108 0.0369925637930931 0.592915102671671 0.928571428571429 26.3 26 3 abnormal pinna reflex 0.00987459793311108 0.0369925637930931 0.592915102671671 0.928571428571429 26.3 26 3 abnormal placing response 0.00987459793311108 0.0369925637930931 0.592915102671671 0.928571428571429 26.3 26 3 abnormal fluid regulation 0.00987459793311108 0.0369925637930931 0.592915102671671 0.928571428571429 26.3 26 3 decreased coping response 0.00987459793311108 0.0369925637930931 0.592915102671671 0.928571428571429 26.3 26 3 decreased vascular permeability 0.00987459793311108 0.0369925637930931 0.592915102671671 0.928571428571429 26.3 26 3 intestinal obstruction 0.00987459793311108 0.0369925637930931 0.592915102671671 0.928571428571429 26.3 26 3 failure of zygotic cell division 0.00987459793311108 0.0369925637930931 0.592915102671671 0.928571428571429 26.3 26 3 abnormal voluntary movement 0.00987459793311108 0.0369925637930931 0.592915102671671 0.928571428571429 26.3 26 3 abnormal vascular endothelial cell migration 0.00987459793311108 0.0369925637930931 0.592915102671671 0.928571428571429 26.3 26 3 vascular smooth muscle hypoplasia 0.00987459793311108 0.0369925637930931 0.592915102671671 0.928571428571429 26.3 26 3 skeletal muscle necrosis 0.00987459793311108 0.0369925637930931 0.592915102671671 0.928571428571429 26.3 26 3 enlarged stomach 0.00987459793311108 0.0369925637930931 0.592915102671671 0.928571428571429 26.3 26 3 split sternum 0.00987459793311108 0.0369925637930931 0.592915102671671 0.928571428571429 26.3 26 3 abnormal squamosal bone morphology 0.00987459793311108 0.0369925637930931 0.592915102671671 0.928571428571429 26.3 26 3 decreased CNS synapse formation 0.00987459793311108 0.0369925637930931 0.592915102671671 0.928571428571429 26.3 26 3 increased circulating growth hormone level 0.00987459793311108 0.0369925637930931 0.592915102671671 0.928571428571429 26.3 26 3 abnormal viscerocranium morphology 0.00987459793311108 0.0369925637930931 0.592915102671671 0.928571428571429 26.3 26 3 spina bifida occulta 0.00987459793311108 0.0369925637930931 0.592915102671671 0.928571428571429 26.3 26 3 decreased cornea thickness 0.00987459793311108 0.0369925637930931 0.592915102671671 0.928571428571429 26.3 26 3 increased stomach tumor incidence 0.00987459793311108 0.0369925637930931 0.592915102671671 0.928571428571429 26.3 26 3 decreased compact bone area 0.00987459793311108 0.0369925637930931 0.592915102671671 0.928571428571429 26.3 26 3 abnormal renal tubule epithelial cell primary cilium morphology 0.00987459793311108 0.0369925637930931 0.592915102671671 0.928571428571429 26.3 26 3 multiple persisting craniopharyngeal ducts 0.00987459793311108 0.0369925637930931 0.592915102671671 0.928571428571429 26.3 26 3 abnormal vitelline vein topology 0.00987459793311108 0.0369925637930931 0.592915102671671 0.928571428571429 26.3 26 3 decreased response to antigen 0.00987459793311108 0.0369925637930931 0.592915102671671 0.928571428571429 26.3 26 3 abnormal myocardial fiber morphology 9.38171911490526e-13 3.03078263614634e-11 0.592444908300005 0.927835051546392 26.3 26 3 abnormal neural tube closure 4.40744813002728e-11 1.0441454498517e-09 0.592365598405989 0.927710843373494 26.3 26 3 thymus hypoplasia 1.42961728186517e-17 8.17511031871173e-16 0.592254104786865 0.927536231884058 26.3 26 3 perimembraneous ventricular septal defect 2.09276585479264e-09 3.94375383620962e-08 0.592254104786865 0.927536231884058 26.3 26 3 abnormal joint morphology 1.0100140554953e-07 1.464962077577e-06 0.592085850779823 0.927272727272727 26.3 26 3 decreased circulating total protein level 1.0100140554953e-07 1.464962077577e-06 0.592085850779823 0.927272727272727 26.3 26 3 neonatal lethality, incomplete penetrance 8.33293709039173e-32 1.65825448098796e-29 0.591862590655095 0.926923076923077 26.3 26 3 short ulna 5.00565186301384e-06 5.11357659517328e-05 0.591802691597241 0.926829268292683 26.3 26 3 increased bone mineral content 4.67441662667149e-14 1.77520784104509e-12 0.591659813110616 0.926605504587156 26.3 26 3 abnormal cochlea morphology 1.53966551957489e-07 2.15770027039016e-06 0.591225885854943 0.925925925925926 26.3 26 3 neurodegeneration 1.53966551957489e-07 2.15770027039016e-06 0.591225885854943 0.925925925925926 26.3 26 3 axon degeneration 1.53966551957489e-07 2.15770027039016e-06 0.591225885854943 0.925925925925926 26.3 26 3 abnormal heart valve morphology 0.000260401714245334 0.00169125134252028 0.591225885854943 0.925925925925926 26.3 26 3 abnormal trigeminal ganglion morphology 0.000260401714245334 0.00169125134252028 0.591225885854943 0.925925925925926 26.3 26 3 abnormal eye muscle morphology 0.000260401714245334 0.00169125134252028 0.591225885854943 0.925925925925926 26.3 26 3 thick interventricular septum 0.000260401714245334 0.00169125134252028 0.591225885854943 0.925925925925926 26.3 26 3 embryonic growth arrest 6.26220645691808e-28 9.44075064338407e-26 0.591122614957851 0.925764192139738 26.3 26 3 cataract 2.33655148755831e-15 1.04723816672095e-13 0.591030439281107 0.925619834710744 26.3 26 3 head bobbing 7.63124435950399e-06 7.51790904723413e-05 0.590634659969088 0.925 26.3 26 3 hypoglycemia 5.04616927402524e-12 1.47674659636915e-10 0.590463013744163 0.924731182795699 26.3 26 3 abnormal definitive hematopoiesis 5.04616927402524e-12 1.47674659636915e-10 0.590463013744163 0.924731182795699 26.3 26 3 enlarged kidney 2.34385135424748e-07 3.16007059278623e-06 0.590333469423464 0.924528301886792 26.3 26 3 prenatal lethality, incomplete penetrance 2.88798976152667e-36 6.84178526837866e-34 0.590214578418612 0.924342105263158 26.3 26 3 abnormal motor capabilities/coordination/movement 1.7796408548864e-16 9.03440127863248e-15 0.590150929698843 0.924242424242424 26.3 26 3 preweaning lethality, incomplete penetrance 2.52793612894664e-48 1.04804018679246e-45 0.5901272754069 0.924205378973105 26.3 26 3 abnormal locomotor behavior 7.66886675493728e-12 2.13143084390017e-10 0.589940612190041 0.923913043478261 26.3 26 3 hemorrhage 3.91798262601267e-28 6.09123861387907e-26 0.589615738761551 0.923404255319149 26.3 26 3 abnormal locomotor activation 1.16446098071705e-11 3.14847466253659e-10 0.589406729283082 0.923076923076923 26.3 26 3 decreased cardiac muscle contractility 3.79959779749883e-13 1.29472596181895e-11 0.589406729283082 0.923076923076923 26.3 26 3 abnormal snout morphology 3.56300494834554e-07 4.68940466085161e-06 0.589406729283082 0.923076923076923 26.3 26 3 abnormal xiphoid process morphology 0.000397109708055519 0.00242705257687495 0.589406729283082 0.923076923076923 26.3 26 3 ventricular hypoplasia 0.000397109708055519 0.00242705257687495 0.589406729283082 0.923076923076923 26.3 26 3 increased susceptibility to otitis media 0.000397109708055519 0.00242705257687495 0.589406729283082 0.923076923076923 26.3 26 3 decreased bone resorption 0.000397109708055519 0.00242705257687495 0.589406729283082 0.923076923076923 26.3 26 3 absent common myeloid progenitor cells 0.0151433309674186 0.0530977779342327 0.589406729283082 0.923076923076923 26.3 26 3 tight skin 0.0151433309674186 0.0530977779342327 0.589406729283082 0.923076923076923 26.3 26 3 pup cannibalization 0.0151433309674186 0.0530977779342327 0.589406729283082 0.923076923076923 26.3 26 3 abnormal grip strength 0.0151433309674186 0.0530977779342327 0.589406729283082 0.923076923076923 26.3 26 3 abnormal pulmonary alveolus epithelial cell morphology 0.0151433309674186 0.0530977779342327 0.589406729283082 0.923076923076923 26.3 26 3 abnormal lung interstitium morphology 0.0151433309674186 0.0530977779342327 0.589406729283082 0.923076923076923 26.3 26 3 abnormal tail bud morphology 0.0151433309674186 0.0530977779342327 0.589406729283082 0.923076923076923 26.3 26 3 increased synaptic depression 0.0151433309674186 0.0530977779342327 0.589406729283082 0.923076923076923 26.3 26 3 abnormal coping response 0.0151433309674186 0.0530977779342327 0.589406729283082 0.923076923076923 26.3 26 3 absent lateral semicircular canal 0.0151433309674186 0.0530977779342327 0.589406729283082 0.923076923076923 26.3 26 3 axonal dystrophy 0.0151433309674186 0.0530977779342327 0.589406729283082 0.923076923076923 26.3 26 3 abnormal afterhyperpolarization 0.0151433309674186 0.0530977779342327 0.589406729283082 0.923076923076923 26.3 26 3 muscle fatigue 0.0151433309674186 0.0530977779342327 0.589406729283082 0.923076923076923 26.3 26 3 abnormal vestibulocochlear ganglion morphology 0.0151433309674186 0.0530977779342327 0.589406729283082 0.923076923076923 26.3 26 3 small otic vesicle 0.0151433309674186 0.0530977779342327 0.589406729283082 0.923076923076923 26.3 26 3 vestibular hair cell degeneration 0.0151433309674186 0.0530977779342327 0.589406729283082 0.923076923076923 26.3 26 3 small interparietal bone 0.0151433309674186 0.0530977779342327 0.589406729283082 0.923076923076923 26.3 26 3 absent hypoglossal nerve 0.0151433309674186 0.0530977779342327 0.589406729283082 0.923076923076923 26.3 26 3 abnormal iris morphology 1.16129144746453e-05 0.000110327017661422 0.589406729283082 0.923076923076923 26.3 26 3 failure of heart looping 1.16129144746453e-05 0.000110327017661422 0.589406729283082 0.923076923076923 26.3 26 3 decreased B-1 B cell number 1.16129144746453e-05 0.000110327017661422 0.589406729283082 0.923076923076923 26.3 26 3 reduced female fertility 1.37289341531583e-27 1.95146992605608e-25 0.588983304908597 0.922413793103448 26.3 26 3 decreased grip strength 4.14038944793142e-26 5.28165064191252e-24 0.588958170128376 0.922374429223744 26.3 26 3 decreased circulating LDL cholesterol level 1.70346354213918e-08 2.71625997504565e-07 0.588639272604328 0.921875 26.3 26 3 hydroencephaly 2.86695579713768e-14 1.13199246752063e-12 0.588552516631947 0.921739130434783 26.3 26 3 abnormal extraembryonic tissue morphology 8.73798318186174e-13 2.84127230913478e-11 0.588443646392096 0.92156862745098 26.3 26 3 abnormal cued conditioning behavior 5.40831738283968e-07 6.78705517913811e-06 0.588443646392096 0.92156862745098 26.3 26 3 cochlear inner hair cell degeneration 5.40831738283968e-07 6.78705517913811e-06 0.588443646392096 0.92156862745098 26.3 26 3 abnormal trophoblast layer morphology 5.40831738283968e-07 6.78705517913811e-06 0.588443646392096 0.92156862745098 26.3 26 3 abnormal muscle physiology 2.677642567049e-11 6.62749839356655e-10 0.588302971363076 0.921348314606742 26.3 26 3 decreased rib number 2.677642567049e-11 6.62749839356655e-10 0.588302971363076 0.921348314606742 26.3 26 3 decreased birth body size 4.34335275491634e-14 1.67505270974487e-12 0.588114170666233 0.921052631578947 26.3 26 3 abnormal frontal bone morphology 1.76383881577112e-05 0.000161604016730412 0.588114170666233 0.921052631578947 26.3 26 3 respiratory failure 3.58929782484949e-18 2.27581933198437e-16 0.58778033102347 0.920529801324503 26.3 26 3 increased T cell number 4.05479913940474e-11 9.6519740280089e-10 0.587732278347618 0.920454545454545 26.3 26 3 perinatal lethality, incomplete penetrance 1.66867102620694e-26 2.24368604199447e-24 0.587668066364842 0.920353982300885 26.3 26 3 abnormal spatial learning 1.80175822297968e-19 1.40058549364436e-17 0.587598733180986 0.920245398773006 26.3 26 3 abnormal kidney morphology 9.05269798236891e-21 8.04235222540809e-19 0.587442040185471 0.92 26.3 26 3 kyphosis 5.43187174778488e-18 3.21709070776545e-16 0.587442040185471 0.92 26.3 26 3 enlarged liver 2.00297398195949e-12 6.22799722515529e-11 0.587442040185471 0.92 26.3 26 3 decreased heart rate 2.00297398195949e-12 6.22799722515529e-11 0.587442040185471 0.92 26.3 26 3 spleen hyperplasia 1.25180526607175e-09 2.4713219042488e-08 0.587442040185471 0.92 26.3 26 3 abnormal inner ear vestibule morphology 0.000603949620164116 0.00351281462359919 0.587442040185471 0.92 26.3 26 3 abnormal thyroid gland morphology 0.000603949620164116 0.00351281462359919 0.587442040185471 0.92 26.3 26 3 increased cellular sensitivity to ionizing radiation 0.000603949620164116 0.00351281462359919 0.587442040185471 0.92 26.3 26 3 decreased placenta weight 0.000603949620164116 0.00351281462359919 0.587442040185471 0.92 26.3 26 3 decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 0.000603949620164116 0.00351281462359919 0.587442040185471 0.92 26.3 26 3 increased liver glycogen level 0.000603949620164116 0.00351281462359919 0.587442040185471 0.92 26.3 26 3 postnatal lethality, complete penetrance 3.8869652648288e-44 1.48751170711717e-41 0.587243535328459 0.919689119170985 26.3 26 3 abnormal coat/hair pigmentation 9.94644922439893e-14 3.61194050302078e-12 0.587213995915213 0.919642857142857 26.3 26 3 abnormal motor coordination/ balance 3.02873575653422e-12 9.13209720530773e-11 0.586926061230543 0.919191919191919 26.3 26 3 abnormal embryo development 2.47886264289425e-16 1.24569107559585e-14 0.586878636694245 0.919117647058823 26.3 26 3 malocclusion 2.67365879932893e-05 0.000229335388390714 0.586751744016041 0.918918918918919 26.3 26 3 abnormal long bone metaphysis morphology 2.67365879932893e-05 0.000229335388390714 0.586751744016041 0.918918918918919 26.3 26 3 abnormal branching of the mammary ductal tree 2.67365879932893e-05 0.000229335388390714 0.586751744016041 0.918918918918919 26.3 26 3 abnormal hair follicle development 2.67365879932893e-05 0.000229335388390714 0.586751744016041 0.918918918918919 26.3 26 3 abnormal humerus morphology 2.67365879932893e-05 0.000229335388390714 0.586751744016041 0.918918918918919 26.3 26 3 decreased anxiety-related response 7.49297275744744e-15 3.1591135142628e-13 0.586611439916563 0.91869918699187 26.3 26 3 organ of Corti degeneration 1.24031431994681e-06 1.43168532290844e-05 0.586399552092862 0.918367346938776 26.3 26 3 abnormal long bone hypertrophic chondrocyte zone 1.24031431994681e-06 1.43168532290844e-05 0.586399552092862 0.918367346938776 26.3 26 3 decreased bone mineral content 3.97688358882178e-24 4.39666574541963e-22 0.586336902568066 0.918269230769231 26.3 26 3 hypoactivity 1.63348978021833e-42 5.80472261184729e-40 0.586019334287202 0.917771883289125 26.3 26 3 decreased bone mineral density 2.90644880116298e-30 5.16413670920923e-28 0.585713704663514 0.917293233082707 26.3 26 3 increased susceptibility to pharmacologically induced seizures 1.04171013056753e-11 2.83197152982157e-10 0.585313626996394 0.916666666666667 26.3 26 3 small heart 1.87370754601383e-06 2.07610134552758e-05 0.585313626996394 0.916666666666667 26.3 26 3 thymus atrophy 1.87370754601383e-06 2.07610134552758e-05 0.585313626996394 0.916666666666667 26.3 26 3 abnormal foregut morphology 0.000915850446299104 0.00503464748103651 0.585313626996394 0.916666666666667 26.3 26 3 decreased body height 0.000915850446299104 0.00503464748103651 0.585313626996394 0.916666666666667 26.3 26 3 abnormal body weight 0.000915850446299104 0.00503464748103651 0.585313626996394 0.916666666666667 26.3 26 3 decreased metastatic potential 0.000915850446299104 0.00503464748103651 0.585313626996394 0.916666666666667 26.3 26 3 apnea 0.000915850446299104 0.00503464748103651 0.585313626996394 0.916666666666667 26.3 26 3 prolonged QT interval 0.000915850446299104 0.00503464748103651 0.585313626996394 0.916666666666667 26.3 26 3 abnormal tumor morphology 0.000915850446299104 0.00503464748103651 0.585313626996394 0.916666666666667 26.3 26 3 abnormal retinal ganglion layer morphology 0.000915850446299104 0.00503464748103651 0.585313626996394 0.916666666666667 26.3 26 3 decreased fatty acid level 0.000915850446299104 0.00503464748103651 0.585313626996394 0.916666666666667 26.3 26 3 abnormal lung saccule morphology 0.000915850446299104 0.00503464748103651 0.585313626996394 0.916666666666667 26.3 26 3 abnormal adipose tissue distribution 0.0231133842783369 0.0732881368927509 0.585313626996394 0.916666666666667 26.3 26 3 amyloidosis 0.0231133842783369 0.0732881368927509 0.585313626996394 0.916666666666667 26.3 26 3 abnormal enteric nervous system morphology 0.0231133842783369 0.0732881368927509 0.585313626996394 0.916666666666667 26.3 26 3 abnormal glossopharyngeal nerve morphology 0.0231133842783369 0.0732881368927509 0.585313626996394 0.916666666666667 26.3 26 3 abnormal mating frequency 0.0231133842783369 0.0732881368927509 0.585313626996394 0.916666666666667 26.3 26 3 impaired embryo implantation 0.0231133842783369 0.0732881368927509 0.585313626996394 0.916666666666667 26.3 26 3 abnormal thymus involution 0.0231133842783369 0.0732881368927509 0.585313626996394 0.916666666666667 26.3 26 3 myocarditis 0.0231133842783369 0.0732881368927509 0.585313626996394 0.916666666666667 26.3 26 3 interstitial pneumonia 0.0231133842783369 0.0732881368927509 0.585313626996394 0.916666666666667 26.3 26 3 abnormal tracheal ciliated epithelium morphology 0.0231133842783369 0.0732881368927509 0.585313626996394 0.916666666666667 26.3 26 3 increased growth rate 0.0231133842783369 0.0732881368927509 0.585313626996394 0.916666666666667 26.3 26 3 abnormal AMPA-mediated synaptic currents 0.0231133842783369 0.0732881368927509 0.585313626996394 0.916666666666667 26.3 26 3 small thyroid gland 0.0231133842783369 0.0732881368927509 0.585313626996394 0.916666666666667 26.3 26 3 abnormal aorta elastic fiber morphology 0.0231133842783369 0.0732881368927509 0.585313626996394 0.916666666666667 26.3 26 3 abnormal vascular endothelial cell development 0.0231133842783369 0.0732881368927509 0.585313626996394 0.916666666666667 26.3 26 3 increased osteosarcoma incidence 0.0231133842783369 0.0732881368927509 0.585313626996394 0.916666666666667 26.3 26 3 abnormal nucleotide metabolism 0.0231133842783369 0.0732881368927509 0.585313626996394 0.916666666666667 26.3 26 3 increased hepatocyte proliferation 0.0231133842783369 0.0732881368927509 0.585313626996394 0.916666666666667 26.3 26 3 decreased cochlear nerve compound action potential 0.0231133842783369 0.0732881368927509 0.585313626996394 0.916666666666667 26.3 26 3 abnormal cochlear outer hair cell physiology 0.0231133842783369 0.0732881368927509 0.585313626996394 0.916666666666667 26.3 26 3 abnormal fatty acid level 0.0231133842783369 0.0732881368927509 0.585313626996394 0.916666666666667 26.3 26 3 abnormal patella morphology 0.0231133842783369 0.0732881368927509 0.585313626996394 0.916666666666667 26.3 26 3 abnormal somatic nervous system physiology 0.0231133842783369 0.0732881368927509 0.585313626996394 0.916666666666667 26.3 26 3 decreased keratinocyte proliferation 0.0231133842783369 0.0732881368927509 0.585313626996394 0.916666666666667 26.3 26 3 increased skeletal muscle glycogen level 0.0231133842783369 0.0732881368927509 0.585313626996394 0.916666666666667 26.3 26 3 abnormal pulmonary valve cusp morphology 0.0231133842783369 0.0732881368927509 0.585313626996394 0.916666666666667 26.3 26 3 abnormal vitelline vein connection 0.0231133842783369 0.0732881368927509 0.585313626996394 0.916666666666667 26.3 26 3 abnormal forebrain development 4.31489367344225e-09 7.72179713142992e-08 0.585313626996394 0.916666666666667 26.3 26 3 impaired wound healing 4.04423851554709e-05 0.000333114016802099 0.585313626996394 0.916666666666667 26.3 26 3 short radius 4.04423851554709e-05 0.000333114016802099 0.585313626996394 0.916666666666667 26.3 26 3 abnormal trophoblast giant cell morphology 4.04423851554709e-05 0.000333114016802099 0.585313626996394 0.916666666666667 26.3 26 3 abnormal lysosome morphology 4.04423851554709e-05 0.000333114016802099 0.585313626996394 0.916666666666667 26.3 26 3 abnormal retinal blood vessel morphology 4.04423851554709e-05 0.000333114016802099 0.585313626996394 0.916666666666667 26.3 26 3 premature death 4.90773554118748e-95 8.1386614391359e-92 0.585128225150655 0.916376306620209 26.3 26 3 increased insulin sensitivity 9.71196785447095e-17 5.08600421852558e-15 0.584941526788513 0.916083916083916 26.3 26 3 abnormal lung morphology 3.87957628342769e-14 1.50788218828537e-12 0.584866481368436 0.915966386554622 26.3 26 3 infertility 7.78703195443459e-13 2.5487160508758e-11 0.584816334195207 0.91588785046729 26.3 26 3 impaired righting response 1.56961008152255e-11 4.13164558496014e-10 0.584753518262426 0.91578947368421 26.3 26 3 decreased birth weight 1.56961008152255e-11 4.13164558496014e-10 0.584753518262426 0.91578947368421 26.3 26 3 postnatal lethality 3.68749361787764e-19 2.77958799226383e-17 0.58467253868643 0.91566265060241 26.3 26 3 postnatal lethality, incomplete penetrance 2.05979854971172e-62 1.13861086497953e-59 0.584564185732634 0.915492957746479 26.3 26 3 increased circulating free fatty acid level 6.50274808490162e-09 1.12604964574488e-07 0.584564185732634 0.915492957746479 26.3 26 3 syndactyly 1.34408252588424e-07 1.92149728915922e-06 0.584411757001022 0.915254237288136 26.3 26 3 extramedullary hematopoiesis 1.17233285734541e-12 3.76281030018929e-11 0.584309658510979 0.915094339622642 26.3 26 3 postnatal growth retardation 5.98935564908163e-67 3.72463054427264e-64 0.584270287197826 0.915032679738562 26.3 26 3 abnormal cell nucleus morphology 2.82568275771989e-06 3.02969218096044e-05 0.584181492321352 0.914893617021277 26.3 26 3 sparse hair 4.78984017013321e-10 1.00972266298359e-08 0.584015814076224 0.914634146341463 26.3 26 3 abnormal action potential 9.78794113301257e-09 1.63956252985648e-07 0.583793331861338 0.914285714285714 26.3 26 3 embryonic lethality between somite formation and embryo turning, complete penetrance 9.78794113301257e-09 1.63956252985648e-07 0.583793331861338 0.914285714285714 26.3 26 3 abnormal embryonic epiblast morphology 6.10382096062257e-05 0.000484314342569335 0.583793331861338 0.914285714285714 26.3 26 3 decreased triglyceride level 6.10382096062257e-05 0.000484314342569335 0.583793331861338 0.914285714285714 26.3 26 3 abnormal hippocampus pyramidal cell morphology 6.10382096062257e-05 0.000484314342569335 0.583793331861338 0.914285714285714 26.3 26 3 lethargy 3.55350274896286e-11 8.54042327347353e-10 0.583597164747137 0.913978494623656 26.3 26 3 glomerulosclerosis 2.02314290843569e-07 2.77276472988086e-06 0.583478788040292 0.913793103448276 26.3 26 3 thrombocytosis 2.02314290843569e-07 2.77276472988086e-06 0.583478788040292 0.913793103448276 26.3 26 3 increased heart weight 4.9767732029993e-16 2.45143036484371e-14 0.583399586358734 0.913669064748201 26.3 26 3 increased exploration in new environment 7.20210641105646e-10 1.46246854673493e-08 0.583342874043544 0.91358024691358 26.3 26 3 increased or absent threshold for auditory brainstem response 7.61024872510056e-32 1.57754114197397e-29 0.583288320328586 0.913494809688581 26.3 26 3 abnormal inner ear morphology 4.25368478695597e-06 4.39047340562364e-05 0.58300013439957 0.91304347826087 26.3 26 3 abnormal allantois morphology 4.25368478695597e-06 4.39047340562364e-05 0.58300013439957 0.91304347826087 26.3 26 3 abnormal myelin sheath morphology 4.25368478695597e-06 4.39047340562364e-05 0.58300013439957 0.91304347826087 26.3 26 3 abnormal carpal bone morphology 0.00138446322839767 0.00723498378285546 0.58300013439957 0.91304347826087 26.3 26 3 abnormal circulating insulin level 0.00138446322839767 0.00723498378285546 0.58300013439957 0.91304347826087 26.3 26 3 abnormal cochlear ganglion morphology 0.00138446322839767 0.00723498378285546 0.58300013439957 0.91304347826087 26.3 26 3 abnormal sacral vertebrae morphology 0.00138446322839767 0.00723498378285546 0.58300013439957 0.91304347826087 26.3 26 3 abnormal corneal stroma morphology 0.00138446322839767 0.00723498378285546 0.58300013439957 0.91304347826087 26.3 26 3 abnormal chondrocyte physiology 0.00138446322839767 0.00723498378285546 0.58300013439957 0.91304347826087 26.3 26 3 abnormal vertebral artery topology 0.00138446322839767 0.00723498378285546 0.58300013439957 0.91304347826087 26.3 26 3 decreased body weight 2.75160747256053e-133 6.84462358799433e-130 0.58282073594295 0.912762520193861 26.3 26 3 abnormal social investigation 1.0817208072751e-09 2.1612694844151e-08 0.582653110510046 0.9125 26.3 26 3 decreased leukocyte cell number 1.12210316051412e-15 5.36775309957474e-14 0.582594851024944 0.912408759124088 26.3 26 3 increased grip strength 8.01363805362903e-11 1.82880042737635e-09 0.582389982505902 0.912087912087912 26.3 26 3 decreased mean corpuscular hemoglobin 2.20913366930782e-08 3.47798734329316e-07 0.582183607600691 0.911764705882353 26.3 26 3 lung hemorrhage 9.19067691959907e-05 0.000689647325414862 0.582183607600691 0.911764705882353 26.3 26 3 abnormal brown adipose tissue morphology 9.19067691959907e-05 0.000689647325414862 0.582183607600691 0.911764705882353 26.3 26 3 abnormal direction of heart looping 9.19067691959907e-05 0.000689647325414862 0.582183607600691 0.911764705882353 26.3 26 3 abnormal embryonic tissue morphology 1.26906937219374e-16 6.51431933942346e-15 0.582055851706989 0.91156462585034 26.3 26 3 decreased B cell proliferation 1.62284100566855e-09 3.11723320586913e-08 0.581945884608612 0.911392405063291 26.3 26 3 trabecula carnea hypoplasia 6.39137451944497e-06 6.43665753729529e-05 0.581766271681264 0.911111111111111 26.3 26 3 cardiomyopathy 6.39137451944497e-06 6.43665753729529e-05 0.581766271681264 0.911111111111111 26.3 26 3 hyperactivity 9.03991428684573e-40 2.64550432806221e-37 0.581728025262772 0.911051212938005 26.3 26 3 abnormal pulmonary alveolus morphology 8.948741438108e-12 2.47333270303263e-10 0.581625782361853 0.910891089108911 26.3 26 3 abnormal heart morphology 6.83628484716053e-25 7.90942258479619e-23 0.580476324293944 0.909090909090909 26.3 26 3 abnormal embryo turning 6.83618016037075e-07 8.31540251781038e-06 0.580476324293944 0.909090909090909 26.3 26 3 deafness 2.0047221975577e-11 5.06268676794393e-10 0.580476324293944 0.909090909090909 26.3 26 3 renal interstitial fibrosis 9.58461924814841e-06 9.25892830282298e-05 0.580476324293944 0.909090909090909 26.3 26 3 cochlear hair cell degeneration 9.58461924814841e-06 9.25892830282298e-05 0.580476324293944 0.909090909090909 26.3 26 3 lethality, incomplete penetrance 9.58461924814841e-06 9.25892830282298e-05 0.580476324293944 0.909090909090909 26.3 26 3 embryonic lethality, incomplete penetrance 9.58461924814841e-06 9.25892830282298e-05 0.580476324293944 0.909090909090909 26.3 26 3 abnormal tooth development 0.000138043434202067 0.000979694843302827 0.580476324293944 0.909090909090909 26.3 26 3 abnormal aorta morphology 0.000138043434202067 0.000979694843302827 0.580476324293944 0.909090909090909 26.3 26 3 enlarged pericardium 0.000138043434202067 0.000979694843302827 0.580476324293944 0.909090909090909 26.3 26 3 abnormal ovarian folliculogenesis 0.000138043434202067 0.000979694843302827 0.580476324293944 0.909090909090909 26.3 26 3 myeloid hyperplasia 0.000138043434202067 0.000979694843302827 0.580476324293944 0.909090909090909 26.3 26 3 increased body size 0.00208573049745755 0.0100840711611772 0.580476324293944 0.909090909090909 26.3 26 3 intestinal inflammation 0.00208573049745755 0.0100840711611772 0.580476324293944 0.909090909090909 26.3 26 3 abnormal tracheal cartilage morphology 0.00208573049745755 0.0100840711611772 0.580476324293944 0.909090909090909 26.3 26 3 abnormal circulating lipid level 0.00208573049745755 0.0100840711611772 0.580476324293944 0.909090909090909 26.3 26 3 abnormal limb posture 0.00208573049745755 0.0100840711611772 0.580476324293944 0.909090909090909 26.3 26 3 abnormal blood-brain barrier function 0.00208573049745755 0.0100840711611772 0.580476324293944 0.909090909090909 26.3 26 3 cleft upper lip 0.00208573049745755 0.0100840711611772 0.580476324293944 0.909090909090909 26.3 26 3 failure of palatal shelf elevation 0.00208573049745755 0.0100840711611772 0.580476324293944 0.909090909090909 26.3 26 3 embryonic lethality before implantation, incomplete penetrance 0.00208573049745755 0.0100840711611772 0.580476324293944 0.909090909090909 26.3 26 3 impaired humoral immune response 0.00208573049745755 0.0100840711611772 0.580476324293944 0.909090909090909 26.3 26 3 absent semicircular canals 0.0350857954711081 0.102077095010972 0.580476324293944 0.909090909090909 26.3 26 3 enlarged cranium 0.0350857954711081 0.102077095010972 0.580476324293944 0.909090909090909 26.3 26 3 abnormal stomach epithelium morphology 0.0350857954711081 0.102077095010972 0.580476324293944 0.909090909090909 26.3 26 3 abnormal sebaceous gland morphology 0.0350857954711081 0.102077095010972 0.580476324293944 0.909090909090909 26.3 26 3 abnormal enteric ganglia morphology 0.0350857954711081 0.102077095010972 0.580476324293944 0.909090909090909 26.3 26 3 abnormal glossopharyngeal ganglion morphology 0.0350857954711081 0.102077095010972 0.580476324293944 0.909090909090909 26.3 26 3 abnormal eye distance/ position 0.0350857954711081 0.102077095010972 0.580476324293944 0.909090909090909 26.3 26 3 social withdrawal 0.0350857954711081 0.102077095010972 0.580476324293944 0.909090909090909 26.3 26 3 abnormal hemoglobin 0.0350857954711081 0.102077095010972 0.580476324293944 0.909090909090909 26.3 26 3 impaired myelopoiesis 0.0350857954711081 0.102077095010972 0.580476324293944 0.909090909090909 26.3 26 3 secondary sex reversal 0.0350857954711081 0.102077095010972 0.580476324293944 0.909090909090909 26.3 26 3 abnormal vestibular ganglion morphology 0.0350857954711081 0.102077095010972 0.580476324293944 0.909090909090909 26.3 26 3 fatigue 0.0350857954711081 0.102077095010972 0.580476324293944 0.909090909090909 26.3 26 3 variable body spotting 0.0350857954711081 0.102077095010972 0.580476324293944 0.909090909090909 26.3 26 3 allodynia 0.0350857954711081 0.102077095010972 0.580476324293944 0.909090909090909 26.3 26 3 fused joints 0.0350857954711081 0.102077095010972 0.580476324293944 0.909090909090909 26.3 26 3 abnormal frequency of paradoxical sleep 0.0350857954711081 0.102077095010972 0.580476324293944 0.909090909090909 26.3 26 3 loss of cortex neurons 0.0350857954711081 0.102077095010972 0.580476324293944 0.909090909090909 26.3 26 3 abnormal radial glial cell morphology 0.0350857954711081 0.102077095010972 0.580476324293944 0.909090909090909 26.3 26 3 abnormal lymph circulation 0.0350857954711081 0.102077095010972 0.580476324293944 0.909090909090909 26.3 26 3 dilated renal glomerular capsule 0.0350857954711081 0.102077095010972 0.580476324293944 0.909090909090909 26.3 26 3 abnormal ureter development 0.0350857954711081 0.102077095010972 0.580476324293944 0.909090909090909 26.3 26 3 abnormal pituitary gland development 0.0350857954711081 0.102077095010972 0.580476324293944 0.909090909090909 26.3 26 3 abnormal crista ampullaris neuroepithelium morphology 0.0350857954711081 0.102077095010972 0.580476324293944 0.909090909090909 26.3 26 3 cyclopia 0.0350857954711081 0.102077095010972 0.580476324293944 0.909090909090909 26.3 26 3 abnormal Bruch membrane morphology 0.0350857954711081 0.102077095010972 0.580476324293944 0.909090909090909 26.3 26 3 abnormal platelet aggregation 0.0350857954711081 0.102077095010972 0.580476324293944 0.909090909090909 26.3 26 3 abnormal superovulation 0.0350857954711081 0.102077095010972 0.580476324293944 0.909090909090909 26.3 26 3 shortened PR interval 0.0350857954711081 0.102077095010972 0.580476324293944 0.909090909090909 26.3 26 3 abnormal brain ependyma motile cilium morphology 0.0350857954711081 0.102077095010972 0.580476324293944 0.909090909090909 26.3 26 3 decreased embryonic cilium length 0.0350857954711081 0.102077095010972 0.580476324293944 0.909090909090909 26.3 26 3 abnormal phrenic nerve innervation pattern to diaphragm 0.0350857954711081 0.102077095010972 0.580476324293944 0.909090909090909 26.3 26 3 chylous ascites 0.0350857954711081 0.102077095010972 0.580476324293944 0.909090909090909 26.3 26 3 hypolactation 0.0350857954711081 0.102077095010972 0.580476324293944 0.909090909090909 26.3 26 3 abnormal renal glomerulus morphology 2.24034567532706e-12 6.9228072886659e-11 0.579943777207436 0.908256880733945 26.3 26 3 decreased hemoglobin content 1.42369971414279e-15 6.4980789705141e-14 0.579652953621187 0.907801418439716 26.3 26 3 respiratory distress 9.177675953753e-19 6.61723737245235e-17 0.579469717951238 0.907514450867052 26.3 26 3 increased cell proliferation 1.02248725340389e-06 1.19130540648345e-05 0.579401368137844 0.907407407407407 26.3 26 3 abnormal mandible morphology 1.02248725340389e-06 1.19130540648345e-05 0.579401368137844 0.907407407407407 26.3 26 3 abnormal apoptosis 1.02248725340389e-06 1.19130540648345e-05 0.579401368137844 0.907407407407407 26.3 26 3 decreased tumor growth/size 1.02248725340389e-06 1.19130540648345e-05 0.579401368137844 0.907407407407407 26.3 26 3 abnormal long bone epiphyseal plate proliferative zone 1.02248725340389e-06 1.19130540648345e-05 0.579401368137844 0.907407407407407 26.3 26 3 abnormal osteoblast physiology 1.02248725340389e-06 1.19130540648345e-05 0.579401368137844 0.907407407407407 26.3 26 3 decreased platelet aggregation 1.02248725340389e-06 1.19130540648345e-05 0.579401368137844 0.907407407407407 26.3 26 3 decreased body size 4.93678260837834e-82 4.91209869533645e-79 0.579312461989595 0.907268170426065 26.3 26 3 edema 1.36968986685518e-18 9.73458155372077e-17 0.579126379353726 0.906976744186046 26.3 26 3 increased oxygen consumption 6.00979349071006e-10 1.24061089694119e-08 0.579126379353726 0.906976744186046 26.3 26 3 abnormal organ of Corti morphology 1.43439677912922e-05 0.000133385494881643 0.579126379353726 0.906976744186046 26.3 26 3 abnormal vasculogenesis 1.43439677912922e-05 0.000133385494881643 0.579126379353726 0.906976744186046 26.3 26 3 abnormal osteoclast physiology 1.10709504098341e-07 1.59184908349494e-06 0.578662335780526 0.90625 26.3 26 3 increased sacral vertebrae number 1.10709504098341e-07 1.59184908349494e-06 0.578662335780526 0.90625 26.3 26 3 abnormal vertebral body morphology 0.000206796549018861 0.0013884113783655 0.578662335780526 0.90625 26.3 26 3 abnormal lymphatic vessel morphology 0.000206796549018861 0.0013884113783655 0.578662335780526 0.90625 26.3 26 3 abnormal heart atrium morphology 0.000206796549018861 0.0013884113783655 0.578662335780526 0.90625 26.3 26 3 abnormal depression-related behavior 0.000206796549018861 0.0013884113783655 0.578662335780526 0.90625 26.3 26 3 abnormal coat/ hair morphology 1.52668794516871e-06 1.7222840197765e-05 0.578285847598495 0.905660377358491 26.3 26 3 abnormal mesoderm development 1.52668794516871e-06 1.7222840197765e-05 0.578285847598495 0.905660377358491 26.3 26 3 abnormal pancreatic islet morphology 1.52668794516871e-06 1.7222840197765e-05 0.578285847598495 0.905660377358491 26.3 26 3 pale liver 1.21116593971266e-08 1.9755903442854e-07 0.578123041898158 0.905405405405405 26.3 26 3 abnormal optic nerve morphology 2.14208742837221e-05 0.000188617432852244 0.577712151321116 0.904761904761905 26.3 26 3 disheveled coat 2.14208742837221e-05 0.000188617432852244 0.577712151321116 0.904761904761905 26.3 26 3 skin edema 2.14208742837221e-05 0.000188617432852244 0.577712151321116 0.904761904761905 26.3 26 3 abnormal spleen white pulp morphology 2.14208742837221e-05 0.000188617432852244 0.577712151321116 0.904761904761905 26.3 26 3 trunk curl 0.00313059669191853 0.0141459750611214 0.577712151321116 0.904761904761905 26.3 26 3 abnormal hematopoietic system physiology 0.00313059669191853 0.0141459750611214 0.577712151321116 0.904761904761905 26.3 26 3 liver degeneration 0.00313059669191853 0.0141459750611214 0.577712151321116 0.904761904761905 26.3 26 3 abnormal tumor vascularization 0.00313059669191853 0.0141459750611214 0.577712151321116 0.904761904761905 26.3 26 3 complete atrioventricular septal defect 0.00313059669191853 0.0141459750611214 0.577712151321116 0.904761904761905 26.3 26 3 embryonic lethality at implantation, complete penetrance 0.00313059669191853 0.0141459750611214 0.577712151321116 0.904761904761905 26.3 26 3 decreased vocalization 0.00313059669191853 0.0141459750611214 0.577712151321116 0.904761904761905 26.3 26 3 abnormal skeleton morphology 1.2377366998767e-12 3.94726928326064e-11 0.577447752167193 0.904347826086957 26.3 26 3 decreased hematocrit 1.17745201913045e-15 5.5262488633717e-14 0.577295632106032 0.904109589041096 26.3 26 3 abnormal seminiferous tubule morphology 1.17745201913045e-15 5.5262488633717e-14 0.577295632106032 0.904109589041096 26.3 26 3 abnormal female meiosis 2.27542542670843e-06 2.48250910041106e-05 0.577127422423018 0.903846153846154 26.3 26 3 abnormal lipid level 1.9862583762121e-09 3.78606721136214e-08 0.576979478966872 0.903614457831325 26.3 26 3 increased tumor incidence 2.06115426451777e-13 7.32445890426851e-12 0.576731315750112 0.903225806451613 26.3 26 3 abnormal mitochondrial ATP synthesis coupled electron transport 0.000308930720966035 0.00195289750547144 0.576731315750112 0.903225806451613 26.3 26 3 abnormal heart left ventricle morphology 2.68185390484528e-08 4.19566766559914e-07 0.576445238708569 0.902777777777778 26.3 26 3 cochlear outer hair cell degeneration 2.68185390484528e-08 4.19566766559914e-07 0.576445238708569 0.902777777777778 26.3 26 3 abnormal developmental patterning 2.95155691395975e-09 5.49962383780889e-08 0.576228936555208 0.902439024390244 26.3 26 3 abnormal mammary gland development 3.19179749520377e-05 0.000267777277211446 0.576228936555208 0.902439024390244 26.3 26 3 arrested B cell differentiation 3.19179749520377e-05 0.000267777277211446 0.576228936555208 0.902439024390244 26.3 26 3 kinked tail 3.63496636513388e-11 8.69421041660628e-10 0.575923568809286 0.901960784313726 26.3 26 3 abnormal gastrulation 3.38505150825212e-06 3.55287579188909e-05 0.575923568809286 0.901960784313726 26.3 26 3 abnormal gluconeogenesis 3.38505150825212e-06 3.55287579188909e-05 0.575923568809286 0.901960784313726 26.3 26 3 abnormal response to novel object 3.38505150825212e-06 3.55287579188909e-05 0.575923568809286 0.901960784313726 26.3 26 3 corneal opacity 3.98239918585989e-08 6.13388109896376e-07 0.575570890567516 0.901408450704225 26.3 26 3 decreased liver weight 3.98239918585989e-08 6.13388109896376e-07 0.575570890567516 0.901408450704225 26.3 26 3 small spleen 4.84816397640293e-10 1.01342923456322e-08 0.575373235728723 0.901098901098901 26.3 26 3 abnormal B cell differentiation 4.84816397640293e-10 1.01342923456322e-08 0.575373235728723 0.901098901098901 26.3 26 3 abnormal bone mineralization 6.73334293983697e-13 2.21843583613834e-11 0.575199266800363 0.900826446280992 26.3 26 3 thin ventricular wall 7.18413833069956e-10 1.46246854673493e-08 0.574671561051005 0.9 26.3 26 3 abnormal axon extension 5.02605187552872e-06 5.12389509851545e-05 0.574671561051005 0.9 26.3 26 3 epidermal hyperplasia 5.41600182134237e-07 6.78705517913811e-06 0.574671561051005 0.9 26.3 26 3 abnormal eating behavior 5.41600182134237e-07 6.78705517913811e-06 0.574671561051005 0.9 26.3 26 3 absent mesoderm 5.41600182134237e-07 6.78705517913811e-06 0.574671561051005 0.9 26.3 26 3 abnormal long bone epiphyseal plate morphology 5.41600182134237e-07 6.78705517913811e-06 0.574671561051005 0.9 26.3 26 3 increased erythrocyte cell number 5.41600182134237e-07 6.78705517913811e-06 0.574671561051005 0.9 26.3 26 3 abnormal microglial cell physiology 0.000460143986936415 0.00277480767879838 0.574671561051005 0.9 26.3 26 3 abnormal cell proliferation 0.00467997186911544 0.0198320784061749 0.574671561051005 0.9 26.3 26 3 small gonad 0.00467997186911544 0.0198320784061749 0.574671561051005 0.9 26.3 26 3 brain inflammation 0.00467997186911544 0.0198320784061749 0.574671561051005 0.9 26.3 26 3 abnormal trachea morphology 0.00467997186911544 0.0198320784061749 0.574671561051005 0.9 26.3 26 3 abnormal Peyer's patch T cell area morphology 0.00467997186911544 0.0198320784061749 0.574671561051005 0.9 26.3 26 3 abnormal lens epithelium morphology 0.00467997186911544 0.0198320784061749 0.574671561051005 0.9 26.3 26 3 absent placental labyrinth 0.00467997186911544 0.0198320784061749 0.574671561051005 0.9 26.3 26 3 abnormal heart right ventricle morphology 0.00467997186911544 0.0198320784061749 0.574671561051005 0.9 26.3 26 3 abnormal induced retinal neovascularization 0.00467997186911544 0.0198320784061749 0.574671561051005 0.9 26.3 26 3 abnormal neuron proliferation 0.00467997186911544 0.0198320784061749 0.574671561051005 0.9 26.3 26 3 decreased muscle cell glucose uptake 0.00467997186911544 0.0198320784061749 0.574671561051005 0.9 26.3 26 3 abnormal lateral semicircular canal morphology 0.0529214773784835 0.138497816916336 0.574671561051005 0.9 26.3 26 3 retarded hair growth 0.0529214773784835 0.138497816916336 0.574671561051005 0.9 26.3 26 3 abnormal prostate gland epithelium morphology 0.0529214773784835 0.138497816916336 0.574671561051005 0.9 26.3 26 3 fused cornea and lens 0.0529214773784835 0.138497816916336 0.574671561051005 0.9 26.3 26 3 absent trophoblast giant cells 0.0529214773784835 0.138497816916336 0.574671561051005 0.9 26.3 26 3 abnormal pituitary secretion 0.0529214773784835 0.138497816916336 0.574671561051005 0.9 26.3 26 3 abnormal immune cell physiology 0.0529214773784835 0.138497816916336 0.574671561051005 0.9 26.3 26 3 rhinitis 0.0529214773784835 0.138497816916336 0.574671561051005 0.9 26.3 26 3 abnormal gland morphology 0.0529214773784835 0.138497816916336 0.574671561051005 0.9 26.3 26 3 abnormal PNS synaptic transmission 0.0529214773784835 0.138497816916336 0.574671561051005 0.9 26.3 26 3 abnormal primordial germ cell migration 0.0529214773784835 0.138497816916336 0.574671561051005 0.9 26.3 26 3 delayed dark adaptation 0.0529214773784835 0.138497816916336 0.574671561051005 0.9 26.3 26 3 aneurysm 0.0529214773784835 0.138497816916336 0.574671561051005 0.9 26.3 26 3 lymphedema 0.0529214773784835 0.138497816916336 0.574671561051005 0.9 26.3 26 3 bifid ureter 0.0529214773784835 0.138497816916336 0.574671561051005 0.9 26.3 26 3 cochlear ganglion hypoplasia 0.0529214773784835 0.138497816916336 0.574671561051005 0.9 26.3 26 3 absent seminal vesicle 0.0529214773784835 0.138497816916336 0.574671561051005 0.9 26.3 26 3 absent CD4-positive, alpha beta T cells 0.0529214773784835 0.138497816916336 0.574671561051005 0.9 26.3 26 3 abnormal pillar cell morphology 0.0529214773784835 0.138497816916336 0.574671561051005 0.9 26.3 26 3 abnormal reproductive system development 0.0529214773784835 0.138497816916336 0.574671561051005 0.9 26.3 26 3 abnormal gas homeostasis 0.0529214773784835 0.138497816916336 0.574671561051005 0.9 26.3 26 3 abnormal utricular macula morphology 0.0529214773784835 0.138497816916336 0.574671561051005 0.9 26.3 26 3 abnormal respiratory conducting tube morphology 0.0529214773784835 0.138497816916336 0.574671561051005 0.9 26.3 26 3 absent coat pigmentation 0.0529214773784835 0.138497816916336 0.574671561051005 0.9 26.3 26 3 abnormal corneal endothelium morphology 0.0529214773784835 0.138497816916336 0.574671561051005 0.9 26.3 26 3 abnormal gonadal fat pad morphology 0.0529214773784835 0.138497816916336 0.574671561051005 0.9 26.3 26 3 decreased thyroxine level 0.0529214773784835 0.138497816916336 0.574671561051005 0.9 26.3 26 3 vascular smooth muscle hyperplasia 0.0529214773784835 0.138497816916336 0.574671561051005 0.9 26.3 26 3 abnormal developmental vascular remodeling 0.0529214773784835 0.138497816916336 0.574671561051005 0.9 26.3 26 3 absent inguinal lymph nodes 0.0529214773784835 0.138497816916336 0.574671561051005 0.9 26.3 26 3 absent axillary lymph nodes 0.0529214773784835 0.138497816916336 0.574671561051005 0.9 26.3 26 3 abnormal spinal cord dorsal column morphology 0.0529214773784835 0.138497816916336 0.574671561051005 0.9 26.3 26 3 decreased transitional stage T2 B cell number 0.0529214773784835 0.138497816916336 0.574671561051005 0.9 26.3 26 3 increased serotonin level 0.0529214773784835 0.138497816916336 0.574671561051005 0.9 26.3 26 3 abnormal retinal blood vessel pattern 0.0529214773784835 0.138497816916336 0.574671561051005 0.9 26.3 26 3 abnormal heart and great artery attachment 0.0529214773784835 0.138497816916336 0.574671561051005 0.9 26.3 26 3 thick aortic valve cusps 0.0529214773784835 0.138497816916336 0.574671561051005 0.9 26.3 26 3 thick aortic valve 0.0529214773784835 0.138497816916336 0.574671561051005 0.9 26.3 26 3 sinus bradycardia 0.0529214773784835 0.138497816916336 0.574671561051005 0.9 26.3 26 3 fusion of atlas and odontoid process 0.0529214773784835 0.138497816916336 0.574671561051005 0.9 26.3 26 3 abnormal pulmonary interalveolar septum morphology 0.0529214773784835 0.138497816916336 0.574671561051005 0.9 26.3 26 3 decreased trabecular bone connectivity density 0.0529214773784835 0.138497816916336 0.574671561051005 0.9 26.3 26 3 increased compact bone area 0.0529214773784835 0.138497816916336 0.574671561051005 0.9 26.3 26 3 decreased circulating glucose level 1.00611172198403e-27 1.47217818143252e-25 0.57444269941777 0.899641577060932 26.3 26 3 decreased circulating serum albumin level 1.18202982002644e-10 2.62526712260336e-09 0.574026587357345 0.898989898989899 26.3 26 3 hunched posture 9.61139904529589e-09 1.62090543221515e-07 0.573863302877937 0.89873417721519 26.3 26 3 abnormal somite development 9.61139904529589e-09 1.62090543221515e-07 0.573863302877937 0.89873417721519 26.3 26 3 decreased erythrocyte cell number 5.1537511938389e-16 2.51371688130868e-14 0.573451451579559 0.898089171974522 26.3 26 3 decreased urine osmolality 7.44756793540356e-06 7.35151795210967e-05 0.573368450935243 0.897959183673469 26.3 26 3 abnormal cornea morphology 1.42085079378257e-08 2.29504308411308e-07 0.573034320136329 0.897435897435897 26.3 26 3 increased hepatocyte apoptosis 7.03612828845386e-05 0.000554750209747353 0.573034320136329 0.897435897435897 26.3 26 3 abnormal circulating hormone level 7.03612828845386e-05 0.000554750209747353 0.573034320136329 0.897435897435897 26.3 26 3 decreased trabecular bone volume 7.03612828845386e-05 0.000554750209747353 0.573034320136329 0.897435897435897 26.3 26 3 abnormal spermatogenesis 2.38444065216021e-18 1.60305300601311e-16 0.572589417713863 0.896739130434783 26.3 26 3 enlarged heart 9.57652960520913e-23 9.72310913998274e-21 0.572469754303683 0.896551724137931 26.3 26 3 increased blood urea nitrogen level 9.9658617453818e-15 4.13168018193954e-13 0.572469754303683 0.896551724137931 26.3 26 3 abnormal microglial cell morphology 0.000683216827303954 0.00392948406455164 0.572469754303683 0.896551724137931 26.3 26 3 focal hair loss 0.000683216827303954 0.00392948406455164 0.572469754303683 0.896551724137931 26.3 26 3 abnormal bone structure 3.97491855733167e-19 2.95152534667538e-17 0.572355671052526 0.896373056994819 26.3 26 3 decreased circulating cholesterol level 3.51696336399831e-18 2.27232373193397e-16 0.572229119686489 0.896174863387978 26.3 26 3 retinal degeneration 3.806245786906e-10 8.16210034045576e-09 0.572011044564657 0.895833333333333 26.3 26 3 curly tail 1.10126695783921e-05 0.000106178354946706 0.572011044564657 0.895833333333333 26.3 26 3 abnormal glucose homeostasis 5.18411861939469e-18 3.10734820861308e-16 0.571864862340133 0.895604395604396 26.3 26 3 decreased compact bone thickness 1.90780944824157e-07 2.62918338088693e-06 0.571812498558214 0.895522388059702 26.3 26 3 rib fusion 1.90780944824157e-07 2.62918338088693e-06 0.571812498558214 0.895522388059702 26.3 26 3 abnormal femur morphology 1.90780944824157e-07 2.62918338088693e-06 0.571812498558214 0.895522388059702 26.3 26 3 microphthalmia 2.44139809382764e-15 1.07486332007014e-13 0.571750209615016 0.895424836601307 26.3 26 3 abnormal retina morphology 1.62808747985004e-20 1.349955868709e-18 0.571630970780894 0.895238095238095 26.3 26 3 abnormal blood homeostasis 1.03290839331484e-11 2.82347211908865e-10 0.571310908647198 0.894736842105263 26.3 26 3 alopecia 5.60781599861667e-10 1.16245352471325e-08 0.571310908647198 0.894736842105263 26.3 26 3 increased grooming behavior 0.000104071286595702 0.000776243854293276 0.571310908647198 0.894736842105263 26.3 26 3 decreased neuron apoptosis 0.000104071286595702 0.000776243854293276 0.571310908647198 0.894736842105263 26.3 26 3 decreased total retina thickness 0.000104071286595702 0.000776243854293276 0.571310908647198 0.894736842105263 26.3 26 3 decreased threshold for auditory brainstem response 0.000104071286595702 0.000776243854293276 0.571310908647198 0.894736842105263 26.3 26 3 abnormal triglyceride level 0.00696532085190248 0.0278411533567761 0.571310908647198 0.894736842105263 26.3 26 3 enlarged adrenal glands 0.00696532085190248 0.0278411533567761 0.571310908647198 0.894736842105263 26.3 26 3 small superior vagus ganglion 0.00696532085190248 0.0278411533567761 0.571310908647198 0.894736842105263 26.3 26 3 decreased grooming behavior 0.00696532085190248 0.0278411533567761 0.571310908647198 0.894736842105263 26.3 26 3 delayed sexual maturation 0.00696532085190248 0.0278411533567761 0.571310908647198 0.894736842105263 26.3 26 3 abnormal neural crest cell migration 0.00696532085190248 0.0278411533567761 0.571310908647198 0.894736842105263 26.3 26 3 abnormal digestive system development 0.00696532085190248 0.0278411533567761 0.571310908647198 0.894736842105263 26.3 26 3 abnormal optic vesicle formation 0.00696532085190248 0.0278411533567761 0.571310908647198 0.894736842105263 26.3 26 3 oliguria 0.00696532085190248 0.0278411533567761 0.571310908647198 0.894736842105263 26.3 26 3 abnormal blastocyst morphology 0.00696532085190248 0.0278411533567761 0.571310908647198 0.894736842105263 26.3 26 3 increased circulating VLDL cholesterol level 0.00696532085190248 0.0278411533567761 0.571310908647198 0.894736842105263 26.3 26 3 decreased liver regeneration 0.00696532085190248 0.0278411533567761 0.571310908647198 0.894736842105263 26.3 26 3 Leydig cell hypoplasia 0.00696532085190248 0.0278411533567761 0.571310908647198 0.894736842105263 26.3 26 3 increased liver cholesterol level 0.00696532085190248 0.0278411533567761 0.571310908647198 0.894736842105263 26.3 26 3 embryonic lethality between implantation and somite formation, incomplete penetrance 0.00696532085190248 0.0278411533567761 0.571310908647198 0.894736842105263 26.3 26 3 impaired swimming 2.81141650123418e-07 3.72981255830402e-06 0.570801718889045 0.893939393939394 26.3 26 3 increased respiratory quotient 1.62489018325389e-05 0.000150536846586371 0.570595876220856 0.893617021276596 26.3 26 3 decreased bone trabecula number 1.62489018325389e-05 0.000150536846586371 0.570595876220856 0.893617021276596 26.3 26 3 azoospermia 1.29205364965781e-15 6.00744570752111e-14 0.570254099715183 0.893081761006289 26.3 26 3 abnormal neuron differentiation 2.23396969064788e-11 5.61313091463294e-10 0.570110675645838 0.892857142857143 26.3 26 3 abnormal eye development 2.57799500472702e-06 2.79423205850042e-05 0.570110675645838 0.892857142857143 26.3 26 3 abnormal jaw morphology 0.0010110313218198 0.00543183674519819 0.570110675645838 0.892857142857143 26.3 26 3 lymphoid hyperplasia 0.0010110313218198 0.00543183674519819 0.570110675645838 0.892857142857143 26.3 26 3 abnormal respiration 0.0010110313218198 0.00543183674519819 0.570110675645838 0.892857142857143 26.3 26 3 failure of blastocyst to hatch from the zona pellucida 0.0010110313218198 0.00543183674519819 0.570110675645838 0.892857142857143 26.3 26 3 increased bone resorption 0.0010110313218198 0.00543183674519819 0.570110675645838 0.892857142857143 26.3 26 3 abnormal renal tubule epithelium morphology 0.0010110313218198 0.00543183674519819 0.570110675645838 0.892857142857143 26.3 26 3 increased brown adipose tissue amount 0.000153515211743468 0.00107872624071151 0.569494339780275 0.891891891891892 26.3 26 3 abnormal vocalization 0.000153515211743468 0.00107872624071151 0.569494339780275 0.891891891891892 26.3 26 3 impaired skeletal muscle contractility 0.000153515211743468 0.00107872624071151 0.569494339780275 0.891891891891892 26.3 26 3 decreased circulating chloride level 0.000153515211743468 0.00107872624071151 0.569494339780275 0.891891891891892 26.3 26 3 increased erythroid progenitor cell number 0.000153515211743468 0.00107872624071151 0.569494339780275 0.891891891891892 26.3 26 3 abnormal respiratory electron transport chain 0.000153515211743468 0.00107872624071151 0.569494339780275 0.891891891891892 26.3 26 3 short tail 1.08884560021071e-08 1.79371088114182e-07 0.569286419247314 0.891566265060241 26.3 26 3 weight loss 7.69634520380717e-17 4.16188232488485e-15 0.569198498564805 0.891428571428571 26.3 26 3 increased sensitivity to xenobiotic induced morbidity/mortality 4.81166658117106e-11 1.12385170147071e-09 0.568866797808065 0.890909090909091 26.3 26 3 abnormal tooth morphology 6.07450943203559e-07 7.46189738873507e-06 0.568685398956723 0.890625 26.3 26 3 decreased bone marrow cell number 9.81848664150083e-08 1.43246249388465e-06 0.568548728589274 0.89041095890411 26.3 26 3 seminiferous tubule degeneration 9.81848664150083e-08 1.43246249388465e-06 0.568548728589274 0.89041095890411 26.3 26 3 decreased percent body fat/body weight 9.81848664150083e-08 1.43246249388465e-06 0.568548728589274 0.89041095890411 26.3 26 3 abnormal vertebrae morphology 7.05034148670163e-11 1.62386337483058e-09 0.568227741304255 0.889908256880734 26.3 26 3 reduced male fertility 3.51598878097997e-21 3.23926744173617e-19 0.568201935057773 0.889867841409692 26.3 26 3 decreased total body fat amount 2.30508676876045e-30 4.24733580540121e-28 0.567789266906681 0.889221556886228 26.3 26 3 decreased insulin secretion 3.82249832713758e-09 6.96590812362984e-08 0.567576850420745 0.888888888888889 26.3 26 3 diluted coat color 5.56029347928739e-06 5.6224512315965e-05 0.567576850420745 0.888888888888889 26.3 26 3 increased circulating corticosterone level 3.5130577077776e-05 0.000294233368622787 0.567576850420745 0.888888888888889 26.3 26 3 decreased susceptibility to pharmacologically induced seizures 0.00149077365853702 0.00766969901884351 0.567576850420745 0.888888888888889 26.3 26 3 abnormal palate morphology 0.00149077365853702 0.00766969901884351 0.567576850420745 0.888888888888889 26.3 26 3 abnormal skin appearance 0.00149077365853702 0.00766969901884351 0.567576850420745 0.888888888888889 26.3 26 3 decreased circulating fructosamine level 0.00149077365853702 0.00766969901884351 0.567576850420745 0.888888888888889 26.3 26 3 abnormal bone trabecula morphology 0.00149077365853702 0.00766969901884351 0.567576850420745 0.888888888888889 26.3 26 3 decreased bone ossification 0.00149077365853702 0.00766969901884351 0.567576850420745 0.888888888888889 26.3 26 3 abnormal neuromuscular synapse morphology 1.43867614339762e-07 2.0391492345878e-06 0.567576850420745 0.888888888888889 26.3 26 3 abnormal reflex 0.000225804805212267 0.00147813013938293 0.567576850420745 0.888888888888889 26.3 26 3 lowered ear position 0.0103164648495511 0.0384164765168537 0.567576850420745 0.888888888888889 26.3 26 3 abnormal thymus cortex morphology 0.0103164648495511 0.0384164765168537 0.567576850420745 0.888888888888889 26.3 26 3 abnormal redox activity 0.0103164648495511 0.0384164765168537 0.567576850420745 0.888888888888889 26.3 26 3 decreased cellular sensitivity to gamma-irradiation 0.0103164648495511 0.0384164765168537 0.567576850420745 0.888888888888889 26.3 26 3 increased circulating glycerol level 0.0103164648495511 0.0384164765168537 0.567576850420745 0.888888888888889 26.3 26 3 decreased pulmonary respiratory rate 0.0103164648495511 0.0384164765168537 0.567576850420745 0.888888888888889 26.3 26 3 abnormal pregnancy 0.0103164648495511 0.0384164765168537 0.567576850420745 0.888888888888889 26.3 26 3 decreased fluid intake 0.0103164648495511 0.0384164765168537 0.567576850420745 0.888888888888889 26.3 26 3 crypts of Lieberkuhn abscesses 0.0792256610171606 0.196345095518405 0.567576850420745 0.888888888888889 26.3 26 3 abnormal urinary bladder urothelium morphology 0.0792256610171606 0.196345095518405 0.567576850420745 0.888888888888889 26.3 26 3 synostosis 0.0792256610171606 0.196345095518405 0.567576850420745 0.888888888888889 26.3 26 3 thick tail 0.0792256610171606 0.196345095518405 0.567576850420745 0.888888888888889 26.3 26 3 absent parathyroid glands 0.0792256610171606 0.196345095518405 0.567576850420745 0.888888888888889 26.3 26 3 absent enteric neurons 0.0792256610171606 0.196345095518405 0.567576850420745 0.888888888888889 26.3 26 3 dilated uterus 0.0792256610171606 0.196345095518405 0.567576850420745 0.888888888888889 26.3 26 3 wavy vibrissae 0.0792256610171606 0.196345095518405 0.567576850420745 0.888888888888889 26.3 26 3 abnormal ion homeostasis 0.0792256610171606 0.196345095518405 0.567576850420745 0.888888888888889 26.3 26 3 decreased level of surface class I molecules 0.0792256610171606 0.196345095518405 0.567576850420745 0.888888888888889 26.3 26 3 abnormal germ cell morphology 0.0792256610171606 0.196345095518405 0.567576850420745 0.888888888888889 26.3 26 3 abnormal vomeronasal organ morphology 0.0792256610171606 0.196345095518405 0.567576850420745 0.888888888888889 26.3 26 3 abnormal laryngeal cartilage morphology 0.0792256610171606 0.196345095518405 0.567576850420745 0.888888888888889 26.3 26 3 abnormal thymus lobule morphology 0.0792256610171606 0.196345095518405 0.567576850420745 0.888888888888889 26.3 26 3 polycythemia 0.0792256610171606 0.196345095518405 0.567576850420745 0.888888888888889 26.3 26 3 enlarged otoliths 0.0792256610171606 0.196345095518405 0.567576850420745 0.888888888888889 26.3 26 3 absent posterior semicircular canal 0.0792256610171606 0.196345095518405 0.567576850420745 0.888888888888889 26.3 26 3 abnormal artery development 0.0792256610171606 0.196345095518405 0.567576850420745 0.888888888888889 26.3 26 3 priapism 0.0792256610171606 0.196345095518405 0.567576850420745 0.888888888888889 26.3 26 3 decreased fear-related response 0.0792256610171606 0.196345095518405 0.567576850420745 0.888888888888889 26.3 26 3 abnormal stria vascularis vasculature morphology 0.0792256610171606 0.196345095518405 0.567576850420745 0.888888888888889 26.3 26 3 short frontal bone 0.0792256610171606 0.196345095518405 0.567576850420745 0.888888888888889 26.3 26 3 absent cochlear outer hair cells 0.0792256610171606 0.196345095518405 0.567576850420745 0.888888888888889 26.3 26 3 decreased cochlear hair cell number 0.0792256610171606 0.196345095518405 0.567576850420745 0.888888888888889 26.3 26 3 decreased thyroid-stimulating hormone level 0.0792256610171606 0.196345095518405 0.567576850420745 0.888888888888889 26.3 26 3 liver hyperplasia 0.0792256610171606 0.196345095518405 0.567576850420745 0.888888888888889 26.3 26 3 abnormal intervertebral disk development 0.0792256610171606 0.196345095518405 0.567576850420745 0.888888888888889 26.3 26 3 abnormal oxygen consumption 0.0792256610171606 0.196345095518405 0.567576850420745 0.888888888888889 26.3 26 3 absent adrenal gland 0.0792256610171606 0.196345095518405 0.567576850420745 0.888888888888889 26.3 26 3 positive geotaxis 0.0792256610171606 0.196345095518405 0.567576850420745 0.888888888888889 26.3 26 3 increased tidal volume 0.0792256610171606 0.196345095518405 0.567576850420745 0.888888888888889 26.3 26 3 enhanced conditioned place preference behavior 0.0792256610171606 0.196345095518405 0.567576850420745 0.888888888888889 26.3 26 3 abnormal optic chiasm morphology 0.0792256610171606 0.196345095518405 0.567576850420745 0.888888888888889 26.3 26 3 eye opacity 0.0792256610171606 0.196345095518405 0.567576850420745 0.888888888888889 26.3 26 3 decreased transitional stage T1 B cell number 0.0792256610171606 0.196345095518405 0.567576850420745 0.888888888888889 26.3 26 3 abnormal telomere morphology 0.0792256610171606 0.196345095518405 0.567576850420745 0.888888888888889 26.3 26 3 abnormal ventricle myocardium morphology 0.0792256610171606 0.196345095518405 0.567576850420745 0.888888888888889 26.3 26 3 shortened ST segment 0.0792256610171606 0.196345095518405 0.567576850420745 0.888888888888889 26.3 26 3 iris coloboma 0.0792256610171606 0.196345095518405 0.567576850420745 0.888888888888889 26.3 26 3 abnormal heart left ventricle pressure 0.0792256610171606 0.196345095518405 0.567576850420745 0.888888888888889 26.3 26 3 abnormal pulmonary alveolar system morphology 0.0792256610171606 0.196345095518405 0.567576850420745 0.888888888888889 26.3 26 3 abnormal pulmonary alveolar parenchyma morphology 0.0792256610171606 0.196345095518405 0.567576850420745 0.888888888888889 26.3 26 3 decreased airway resistance 0.0792256610171606 0.196345095518405 0.567576850420745 0.888888888888889 26.3 26 3 abnormal oxidative phosphorylation 0.0792256610171606 0.196345095518405 0.567576850420745 0.888888888888889 26.3 26 3 abnormal lung lobe morphology 0.0792256610171606 0.196345095518405 0.567576850420745 0.888888888888889 26.3 26 3 decreased pancreatic beta cell proliferation 0.0792256610171606 0.196345095518405 0.567576850420745 0.888888888888889 26.3 26 3 increased myeloid cell number 0.0792256610171606 0.196345095518405 0.567576850420745 0.888888888888889 26.3 26 3 abnormal ductus venosus valve topology 0.0792256610171606 0.196345095518405 0.567576850420745 0.888888888888889 26.3 26 3 abnormal coronary sinus connection 0.0792256610171606 0.196345095518405 0.567576850420745 0.888888888888889 26.3 26 3 decreased bone mineral density of femur 0.0792256610171606 0.196345095518405 0.567576850420745 0.888888888888889 26.3 26 3 increased bone mineralization 0.0792256610171606 0.196345095518405 0.567576850420745 0.888888888888889 26.3 26 3 increased endoplasmic reticulum stress 0.0792256610171606 0.196345095518405 0.567576850420745 0.888888888888889 26.3 26 3 abnormal liver morphology 8.61435166198435e-17 4.6082150019755e-15 0.567180497871569 0.888268156424581 26.3 26 3 atelectasis 2.10464404234687e-07 2.87653959084497e-06 0.566577595402399 0.887323943661972 26.3 26 3 increased eosinophil cell number 1.30322105785491e-06 1.50081591732134e-05 0.566432542254575 0.887096774193548 26.3 26 3 decreased blood urea nitrogen level 5.14668864278136e-05 0.000410991589050357 0.565964416186595 0.886363636363636 26.3 26 3 thick pulmonary interalveolar septum 0.000331138106016669 0.00208269542026919 0.565549790240671 0.885714285714286 26.3 26 3 increased circulating serum albumin level 0.000331138106016669 0.00208269542026919 0.565549790240671 0.885714285714286 26.3 26 3 abnormal midbrain development 0.000331138106016669 0.00208269542026919 0.565549790240671 0.885714285714286 26.3 26 3 increased osteoclast cell number 1.90351021479047e-06 2.09977013715801e-05 0.565250715787873 0.885245901639344 26.3 26 3 increased double-negative T cell number 1.90351021479047e-06 2.09977013715801e-05 0.565250715787873 0.885245901639344 26.3 26 3 increased bone mineral density 7.7274815625191e-11 1.77162307712131e-09 0.565065448427733 0.884955752212389 26.3 26 3 increased anxiety-related response 5.11441956211936e-13 1.7076669343318e-11 0.565024796237199 0.884892086330935 26.3 26 3 absent gastric milk in neonates 7.28551564603443e-08 1.0851928245216e-06 0.564848115562953 0.884615384615385 26.3 26 3 abnormal skin condition 1.18921848000869e-05 0.000111629470529118 0.564848115562953 0.884615384615385 26.3 26 3 abnormal hair growth 1.18921848000869e-05 0.000111629470529118 0.564848115562953 0.884615384615385 26.3 26 3 abnormal stomach morphology 0.00218972227966335 0.0104950562055156 0.564848115562953 0.884615384615385 26.3 26 3 thick skin 0.00218972227966335 0.0104950562055156 0.564848115562953 0.884615384615385 26.3 26 3 heart inflammation 0.00218972227966335 0.0104950562055156 0.564848115562953 0.884615384615385 26.3 26 3 increased leukemia incidence 0.00218972227966335 0.0104950562055156 0.564848115562953 0.884615384615385 26.3 26 3 abnormal tectorial membrane morphology 0.00218972227966335 0.0104950562055156 0.564848115562953 0.884615384615385 26.3 26 3 abnormal left-right axis patterning 7.52053636261891e-05 0.000577386858086869 0.564276985011322 0.883720930232558 26.3 26 3 abnormal homeostasis 7.52053636261891e-05 0.000577386858086869 0.564276985011322 0.883720930232558 26.3 26 3 abnormal blood circulation 7.52053636261891e-05 0.000577386858086869 0.564276985011322 0.883720930232558 26.3 26 3 decreased B cell number 1.97135781241757e-18 1.34349385161334e-16 0.564132816134212 0.883495145631068 26.3 26 3 polyuria 1.06068137683437e-07 1.53397960748575e-06 0.563891286456974 0.883116883116883 26.3 26 3 decreased circulating HDL cholesterol level 6.51990887957012e-12 1.83257325852324e-10 0.563696930544822 0.8828125 26.3 26 3 decreased lymphocyte cell number 6.51990887957012e-12 1.83257325852324e-10 0.563696930544822 0.8828125 26.3 26 3 short maxilla 0.000484068421747639 0.0028945197093684 0.563403491226475 0.882352941176471 26.3 26 3 overexpanded pulmonary alveoli 0.000484068421747639 0.0028945197093684 0.563403491226475 0.882352941176471 26.3 26 3 thin skin 0.000484068421747639 0.0028945197093684 0.563403491226475 0.882352941176471 26.3 26 3 abnormal vision 0.000484068421747639 0.0028945197093684 0.563403491226475 0.882352941176471 26.3 26 3 decreased osteoblast cell number 0.000484068421747639 0.0028945197093684 0.563403491226475 0.882352941176471 26.3 26 3 abnormal touch/ nociception 0.0151982383474065 0.0530977779342327 0.563403491226475 0.882352941176471 26.3 26 3 abnormal glutamate-mediated receptor currents 0.0151982383474065 0.0530977779342327 0.563403491226475 0.882352941176471 26.3 26 3 decreased vasoconstriction 0.0151982383474065 0.0530977779342327 0.563403491226475 0.882352941176471 26.3 26 3 abnormal ectoplacental cone morphology 0.0151982383474065 0.0530977779342327 0.563403491226475 0.882352941176471 26.3 26 3 common atrium 0.0151982383474065 0.0530977779342327 0.563403491226475 0.882352941176471 26.3 26 3 abnormal survival 0.0151982383474065 0.0530977779342327 0.563403491226475 0.882352941176471 26.3 26 3 delayed heart development 0.0151982383474065 0.0530977779342327 0.563403491226475 0.882352941176471 26.3 26 3 abnormal ductus venosus valve morphology 0.0151982383474065 0.0530977779342327 0.563403491226475 0.882352941176471 26.3 26 3 impaired hematopoiesis 1.73335546301033e-05 0.000159989673997706 0.563403491226475 0.882352941176471 26.3 26 3 enlarged spleen 6.5613840920139e-25 7.77211568042123e-23 0.563142656276833 0.881944444444444 26.3 26 3 anemia 1.46454617423033e-18 1.02621369250646e-16 0.562869459481237 0.881516587677725 26.3 26 3 abnormal pancreas morphology 0.000109596519897574 0.000813359853522807 0.56250919997056 0.880952380952381 26.3 26 3 increased monocyte cell number 2.08436544045441e-09 3.94285858032726e-08 0.561901081916538 0.88 26.3 26 3 decreased double-positive T cell number 2.08436544045441e-09 3.94285858032726e-08 0.561901081916538 0.88 26.3 26 3 kidney inflammation 2.5205352374486e-05 0.000218461024500118 0.561901081916538 0.88 26.3 26 3 decreased circulating alkaline phosphatase level 2.5205352374486e-05 0.000218461024500118 0.561901081916538 0.88 26.3 26 3 decreased oocyte number 2.5205352374486e-05 0.000218461024500118 0.561901081916538 0.88 26.3 26 3 decreased respiratory quotient 2.5205352374486e-05 0.000218461024500118 0.561901081916538 0.88 26.3 26 3 abnormal primitive streak morphology 0.00320312317128899 0.0144213011558034 0.561901081916538 0.88 26.3 26 3 abnormal egg cylinder morphology 0.00320312317128899 0.0144213011558034 0.561901081916538 0.88 26.3 26 3 abnormal energy expenditure 0.00320312317128899 0.0144213011558034 0.561901081916538 0.88 26.3 26 3 abnormal preimplantation embryo development 0.00320312317128899 0.0144213011558034 0.561901081916538 0.88 26.3 26 3 increased thermal nociceptive threshold 1.26366457241364e-08 2.04779519470941e-07 0.561339742174364 0.879120879120879 26.3 26 3 abnormal enzyme/coenzyme activity 6.73508089309918e-14 2.5193253716668e-12 0.5612503568651 0.878980891719745 26.3 26 3 insulin resistance 6.9359398003151e-12 1.93855620823413e-10 0.561127113484146 0.878787878787879 26.3 26 3 increased mean corpuscular hemoglobin 3.01795647850835e-09 5.60236323902203e-08 0.561127113484146 0.878787878787879 26.3 26 3 dextrocardia 0.000705256631440617 0.00396340431249452 0.561127113484146 0.878787878787879 26.3 26 3 abnormal skeleton physiology 0.000705256631440617 0.00396340431249452 0.561127113484146 0.878787878787879 26.3 26 3 no abnormal phenotype detected 1.48979839581469e-142 7.41174701917807e-139 0.560870610977734 0.878386167146974 26.3 26 3 Leydig cell hyperplasia 0.000159263733534852 0.00110661602560878 0.560655181513175 0.878048780487805 26.3 26 3 hemopericardium 0.000159263733534852 0.00110661602560878 0.560655181513175 0.878048780487805 26.3 26 3 lethality at weaning, incomplete penetrance 0.000159263733534852 0.00110661602560878 0.560655181513175 0.878048780487805 26.3 26 3 increased circulating LDL cholesterol level 3.65625646864764e-05 0.0003036707167199 0.560337349777624 0.877551020408163 26.3 26 3 increased T cell derived lymphoma incidence 3.65625646864764e-05 0.0003036707167199 0.560337349777624 0.877551020408163 26.3 26 3 abnormal respiratory system physiology 3.65625646864764e-05 0.0003036707167199 0.560337349777624 0.877551020408163 26.3 26 3 decreased circulating creatinine level 3.65625646864764e-05 0.0003036707167199 0.560337349777624 0.877551020408163 26.3 26 3 abnormal lipid homeostasis 1.44795982668443e-11 3.87290329986829e-10 0.559936392818928 0.876923076923077 26.3 26 3 abnormal skeleton development 1.11037659523596e-07 1.59196644417835e-06 0.559693838609346 0.876543209876543 26.3 26 3 spleen hypoplasia 1.50762627307085e-09 2.92985965176855e-08 0.559468609700449 0.876190476190476 26.3 26 3 increased circulating HDL cholesterol level 1.50762627307085e-09 2.92985965176855e-08 0.559468609700449 0.876190476190476 26.3 26 3 impaired glucose tolerance 1.7016369184448e-20 1.38781043758408e-18 0.558708462132921 0.875 26.3 26 3 abnormal urine homeostasis 9.08716019966574e-09 1.55356089324182e-07 0.558708462132921 0.875 26.3 26 3 decreased caudal vertebrae number 2.87229707956752e-06 3.07304902598891e-05 0.558708462132921 0.875 26.3 26 3 vertebral transformation 5.29025276115672e-05 0.000421778966133889 0.558708462132921 0.875 26.3 26 3 abnormal long term potentiation 0.00102386992459625 0.00547715362888855 0.558708462132921 0.875 26.3 26 3 abnormal spongiotrophoblast layer morphology 0.00102386992459625 0.00547715362888855 0.558708462132921 0.875 26.3 26 3 bradykinesia 0.00102386992459625 0.00547715362888855 0.558708462132921 0.875 26.3 26 3 increased stereotypic behavior 0.00466475270308764 0.0198320784061749 0.558708462132921 0.875 26.3 26 3 abnormal osteoblast morphology 0.00466475270308764 0.0198320784061749 0.558708462132921 0.875 26.3 26 3 decreased mast cell number 0.0222573302925825 0.0718094800295705 0.558708462132921 0.875 26.3 26 3 reduced male mating frequency 0.0222573302925825 0.0718094800295705 0.558708462132921 0.875 26.3 26 3 abnormal meiosis 0.0222573302925825 0.0718094800295705 0.558708462132921 0.875 26.3 26 3 paternal imprinting 0.0222573302925825 0.0718094800295705 0.558708462132921 0.875 26.3 26 3 bowed radius 0.0222573302925825 0.0718094800295705 0.558708462132921 0.875 26.3 26 3 decreased circulating growth hormone level 0.0222573302925825 0.0718094800295705 0.558708462132921 0.875 26.3 26 3 blepharitis 0.0222573302925825 0.0718094800295705 0.558708462132921 0.875 26.3 26 3 loose skin 0.0222573302925825 0.0718094800295705 0.558708462132921 0.875 26.3 26 3 decreased circulating triiodothyronine level 0.0222573302925825 0.0718094800295705 0.558708462132921 0.875 26.3 26 3 decreased liver cholesterol level 0.0222573302925825 0.0718094800295705 0.558708462132921 0.875 26.3 26 3 decreased skeletal muscle weight 0.0222573302925825 0.0718094800295705 0.558708462132921 0.875 26.3 26 3 abnormal pulmonary alveolus wall morphology 0.0222573302925825 0.0718094800295705 0.558708462132921 0.875 26.3 26 3 decreased midbrain size 0.0222573302925825 0.0718094800295705 0.558708462132921 0.875 26.3 26 3 decreased adipocyte glucose uptake 0.0222573302925825 0.0718094800295705 0.558708462132921 0.875 26.3 26 3 abnormal ear pigmentation 0.117539593282415 0.2582859878887 0.558708462132921 0.875 26.3 26 3 abnormal bone marrow development 0.117539593282415 0.2582859878887 0.558708462132921 0.875 26.3 26 3 pointed snout 0.117539593282415 0.2582859878887 0.558708462132921 0.875 26.3 26 3 abnormal esophageal epithelium morphology 0.117539593282415 0.2582859878887 0.558708462132921 0.875 26.3 26 3 enlarged pituitary gland 0.117539593282415 0.2582859878887 0.558708462132921 0.875 26.3 26 3 abnormal hypoglossal nerve morphology 0.117539593282415 0.2582859878887 0.558708462132921 0.875 26.3 26 3 absent skin pigmentation 0.117539593282415 0.2582859878887 0.558708462132921 0.875 26.3 26 3 dermal cysts 0.117539593282415 0.2582859878887 0.558708462132921 0.875 26.3 26 3 abnormal pupil morphology 0.117539593282415 0.2582859878887 0.558708462132921 0.875 26.3 26 3 spinning 0.117539593282415 0.2582859878887 0.558708462132921 0.875 26.3 26 3 poor grooming 0.117539593282415 0.2582859878887 0.558708462132921 0.875 26.3 26 3 abnormal circulating calcium level 0.117539593282415 0.2582859878887 0.558708462132921 0.875 26.3 26 3 abnormal atrial thrombosis 0.117539593282415 0.2582859878887 0.558708462132921 0.875 26.3 26 3 preneoplasia 0.117539593282415 0.2582859878887 0.558708462132921 0.875 26.3 26 3 abnormal hepatobiliary system morphology 0.117539593282415 0.2582859878887 0.558708462132921 0.875 26.3 26 3 abnormal secondary sex determination 0.117539593282415 0.2582859878887 0.558708462132921 0.875 26.3 26 3 coarse hair 0.117539593282415 0.2582859878887 0.558708462132921 0.875 26.3 26 3 abnormal thyroid physiology 0.117539593282415 0.2582859878887 0.558708462132921 0.875 26.3 26 3 head spot 0.117539593282415 0.2582859878887 0.558708462132921 0.875 26.3 26 3 abnormal muscle precursor cell migration 0.117539593282415 0.2582859878887 0.558708462132921 0.875 26.3 26 3 decreased corneal stroma thickness 0.117539593282415 0.2582859878887 0.558708462132921 0.875 26.3 26 3 abnormal soft palate morphology 0.117539593282415 0.2582859878887 0.558708462132921 0.875 26.3 26 3 abnormal cellular cholesterol metabolism 0.117539593282415 0.2582859878887 0.558708462132921 0.875 26.3 26 3 abnormal neuron apoptosis 0.117539593282415 0.2582859878887 0.558708462132921 0.875 26.3 26 3 abnormal umbilical artery morphology 0.117539593282415 0.2582859878887 0.558708462132921 0.875 26.3 26 3 colon polyps 0.117539593282415 0.2582859878887 0.558708462132921 0.875 26.3 26 3 liver failure 0.117539593282415 0.2582859878887 0.558708462132921 0.875 26.3 26 3 pulmonary interstitial fibrosis 0.117539593282415 0.2582859878887 0.558708462132921 0.875 26.3 26 3 abnormal gastric gland morphology 0.117539593282415 0.2582859878887 0.558708462132921 0.875 26.3 26 3 absent cochlear microphonics 0.117539593282415 0.2582859878887 0.558708462132921 0.875 26.3 26 3 increased epididymis weight 0.117539593282415 0.2582859878887 0.558708462132921 0.875 26.3 26 3 abnormal kidney epithelium morphology 0.117539593282415 0.2582859878887 0.558708462132921 0.875 26.3 26 3 abnormal NK cell morphology 0.117539593282415 0.2582859878887 0.558708462132921 0.875 26.3 26 3 ectrodactyly 0.117539593282415 0.2582859878887 0.558708462132921 0.875 26.3 26 3 Sertoli cell hypoplasia 0.117539593282415 0.2582859878887 0.558708462132921 0.875 26.3 26 3 abnormal circulating corticosterone level 0.117539593282415 0.2582859878887 0.558708462132921 0.875 26.3 26 3 stomach epithelial hyperplasia 0.117539593282415 0.2582859878887 0.558708462132921 0.875 26.3 26 3 choroidal neovascularization 0.117539593282415 0.2582859878887 0.558708462132921 0.875 26.3 26 3 increased pulmonary ventilation 0.117539593282415 0.2582859878887 0.558708462132921 0.875 26.3 26 3 abnormal thymus epithelium morphology 0.117539593282415 0.2582859878887 0.558708462132921 0.875 26.3 26 3 abnormal mitotic spindle assembly checkpoint 0.117539593282415 0.2582859878887 0.558708462132921 0.875 26.3 26 3 abnormal frontonasal prominence morphology 0.117539593282415 0.2582859878887 0.558708462132921 0.875 26.3 26 3 decreased hippocampus pyramidal cell number 0.117539593282415 0.2582859878887 0.558708462132921 0.875 26.3 26 3 abnormal lateral plate mesoderm morphology 0.117539593282415 0.2582859878887 0.558708462132921 0.875 26.3 26 3 abnormal circulating serum amyloid protein level 0.117539593282415 0.2582859878887 0.558708462132921 0.875 26.3 26 3 ostium secundum atrial septal defect 0.117539593282415 0.2582859878887 0.558708462132921 0.875 26.3 26 3 heart right ventricle hypoplasia 0.117539593282415 0.2582859878887 0.558708462132921 0.875 26.3 26 3 abnormal hepatic vein morphology 0.117539593282415 0.2582859878887 0.558708462132921 0.875 26.3 26 3 anomalous pulmonary venous connection 0.117539593282415 0.2582859878887 0.558708462132921 0.875 26.3 26 3 increased heart right ventricle size 0.117539593282415 0.2582859878887 0.558708462132921 0.875 26.3 26 3 abnormal visual evoked potential 0.117539593282415 0.2582859878887 0.558708462132921 0.875 26.3 26 3 increased susceptibility to parasitic infection induced morbidity/mortality 0.117539593282415 0.2582859878887 0.558708462132921 0.875 26.3 26 3 impaired mucociliary clearance 0.117539593282415 0.2582859878887 0.558708462132921 0.875 26.3 26 3 abnormal heart right ventricle pressure 0.117539593282415 0.2582859878887 0.558708462132921 0.875 26.3 26 3 lung situs inversus 0.117539593282415 0.2582859878887 0.558708462132921 0.875 26.3 26 3 decreased lung compliance 0.117539593282415 0.2582859878887 0.558708462132921 0.875 26.3 26 3 abnormal bronchus epithelium morphology 0.117539593282415 0.2582859878887 0.558708462132921 0.875 26.3 26 3 abnormal macrophage activation involved in immune response 0.117539593282415 0.2582859878887 0.558708462132921 0.875 26.3 26 3 absent Reichert's membrane 0.117539593282415 0.2582859878887 0.558708462132921 0.875 26.3 26 3 abnormal heart echocardiography feature 0.117539593282415 0.2582859878887 0.558708462132921 0.875 26.3 26 3 shortened PQ interval 0.117539593282415 0.2582859878887 0.558708462132921 0.875 26.3 26 3 increased cornea thickness 0.117539593282415 0.2582859878887 0.558708462132921 0.875 26.3 26 3 small thymus medulla 0.117539593282415 0.2582859878887 0.558708462132921 0.875 26.3 26 3 absent hypoglossal canal 0.117539593282415 0.2582859878887 0.558708462132921 0.875 26.3 26 3 embryo cyst 0.117539593282415 0.2582859878887 0.558708462132921 0.875 26.3 26 3 increased circulating insulin level 1.01894995173043e-13 3.67338841294122e-12 0.558708462132921 0.875 26.3 26 3 short femur 3.80940639201299e-08 5.90398654213851e-07 0.558708462132921 0.875 26.3 26 3 abnormal retinal pigment epithelium morphology 1.60221412578398e-07 2.23904923476834e-06 0.558708462132921 0.875 26.3 26 3 abnormal inflammatory response 6.76641933499164e-07 8.25071965479986e-06 0.558708462132921 0.875 26.3 26 3 abnormal female reproductive system morphology 0.000230754644499886 0.00150854711745983 0.558708462132921 0.875 26.3 26 3 abnormal spleen morphology 1.23288864557406e-14 5.06910827415781e-13 0.55779104265487 0.873563218390805 26.3 26 3 abnormal retinal pigmentation 5.48644808622208e-08 8.29637666533581e-07 0.55779104265487 0.873563218390805 26.3 26 3 abnormal response to infection 2.30805520699956e-07 3.12026485185403e-06 0.557698139416587 0.873417721518987 26.3 26 3 abnormal ovary morphology 9.74998262300292e-07 1.16351879080883e-05 0.557584300237281 0.873239436619718 26.3 26 3 small testis 2.5103860382256e-22 2.44885696866124e-20 0.557551715834509 0.873188405797101 26.3 26 3 increased total body fat amount 1.50073538963077e-11 3.99259816225298e-10 0.557517186094258 0.873134328358209 26.3 26 3 abnormal platelet physiology 1.77000017356606e-05 0.000161870420284764 0.557257271322186 0.872727272727273 26.3 26 3 hepatic necrosis 7.63425416968438e-05 0.000584314069141228 0.557010260120359 0.872340425531915 26.3 26 3 abnormal innervation 7.63425416968438e-05 0.000584314069141228 0.557010260120359 0.872340425531915 26.3 26 3 increased circulating alanine transaminase level 3.31916410000463e-07 4.38006403117322e-06 0.556661910989577 0.871794871794872 26.3 26 3 abnormal heart looping 0.000333299311831613 0.00209100135732947 0.556661910989577 0.871794871794872 26.3 26 3 increased vascular permeability 0.000333299311831613 0.00209100135732947 0.556661910989577 0.871794871794872 26.3 26 3 dehydration 1.40225895874898e-06 1.59274847483475e-05 0.556428019430338 0.871428571428571 26.3 26 3 abnormal T cell differentiation 6.46174118447735e-09 1.12402665709003e-07 0.556337704867859 0.871287128712871 26.3 26 3 abnormal retinal photoreceptor layer morphology 0.00148083353223647 0.00766612572619819 0.556133768759037 0.870967741935484 26.3 26 3 inner cell mass degeneration 0.00148083353223647 0.00766612572619819 0.556133768759037 0.870967741935484 26.3 26 3 decreased neuronal precursor cell number 0.00148083353223647 0.00766612572619819 0.556133768759037 0.870967741935484 26.3 26 3 abnormal small intestine morphology 2.54650191724356e-05 0.0002203277745789 0.555752332703646 0.87037037037037 26.3 26 3 abnormal liver physiology 9.26583496394619e-09 1.57487972255788e-07 0.555515842349305 0.87 26.3 26 3 abnormal sleep pattern 0.000109864888757251 0.000813359853522807 0.555238223237686 0.869565217391304 26.3 26 3 abnormal lymphocyte physiology 0.000109864888757251 0.000813359853522807 0.555238223237686 0.869565217391304 26.3 26 3 atrial septal defect 0.000109864888757251 0.000813359853522807 0.555238223237686 0.869565217391304 26.3 26 3 abnormal retinal cone cell morphology 0.00676084562452339 0.0276832979275752 0.555238223237686 0.869565217391304 26.3 26 3 abnormal innervation pattern to muscle 0.00676084562452339 0.0276832979275752 0.555238223237686 0.869565217391304 26.3 26 3 bidirectional circling 0.00676084562452339 0.0276832979275752 0.555238223237686 0.869565217391304 26.3 26 3 failure of embryo implantation 0.00676084562452339 0.0276832979275752 0.555238223237686 0.869565217391304 26.3 26 3 conjunctivitis 0.00676084562452339 0.0276832979275752 0.555238223237686 0.869565217391304 26.3 26 3 pancreas inflammation 0.00676084562452339 0.0276832979275752 0.555238223237686 0.869565217391304 26.3 26 3 abnormal cardiovascular development 0.00676084562452339 0.0276832979275752 0.555238223237686 0.869565217391304 26.3 26 3 abnormal crista ampullaris morphology 0.00676084562452339 0.0276832979275752 0.555238223237686 0.869565217391304 26.3 26 3 dilated heart 0.00676084562452339 0.0276832979275752 0.555238223237686 0.869565217391304 26.3 26 3 decreased effector memory CD8-positive, alpha-beta T cell number 0.00676084562452339 0.0276832979275752 0.555238223237686 0.869565217391304 26.3 26 3 increased T cell proliferation 3.18216290490079e-09 5.86342979699312e-08 0.554978766124023 0.869158878504673 26.3 26 3 increased circulating triglyceride level 5.29507992411095e-12 1.5139668173823e-10 0.554855300325108 0.868965517241379 26.3 26 3 thrombocytopenia 5.29507992411095e-12 1.5139668173823e-10 0.554855300325108 0.868965517241379 26.3 26 3 female infertility 9.22774012279381e-21 8.05403633524547e-19 0.554507646628162 0.868421052631579 26.3 26 3 abnormal retinal outer nuclear layer morphology 0.000479845117718729 0.00288661361626442 0.554507646628162 0.868421052631579 26.3 26 3 lung inflammation 3.13239999597719e-11 7.60179999023732e-10 0.554013433039367 0.867647058823529 26.3 26 3 decreased circulating alanine transaminase level 2.88350133886626e-06 3.07841612893984e-05 0.554013433039367 0.867647058823529 26.3 26 3 abnormal rib morphology 4.47187916702687e-11 1.05438857137245e-09 0.553387429160227 0.866666666666667 26.3 26 3 altered response to myocardial infarction 0.000157652897203058 0.00110003248749679 0.553387429160227 0.866666666666667 26.3 26 3 abnormal ovarian follicle morphology 0.000157652897203058 0.00110003248749679 0.553387429160227 0.866666666666667 26.3 26 3 abnormal ectoderm development 0.000157652897203058 0.00110003248749679 0.553387429160227 0.866666666666667 26.3 26 3 albuminuria 0.000157652897203058 0.00110003248749679 0.553387429160227 0.866666666666667 26.3 26 3 abnormal cell migration 0.000157652897203058 0.00110003248749679 0.553387429160227 0.866666666666667 26.3 26 3 gastrointestinal hemorrhage 0.00213319028969298 0.0102735931183181 0.553387429160227 0.866666666666667 26.3 26 3 increased metastatic potential 0.00213319028969298 0.0102735931183181 0.553387429160227 0.866666666666667 26.3 26 3 abnormal response to new environment 0.00213319028969298 0.0102735931183181 0.553387429160227 0.866666666666667 26.3 26 3 abnormal spleen marginal zone morphology 0.00213319028969298 0.0102735931183181 0.553387429160227 0.866666666666667 26.3 26 3 decreased chondrocyte number 0.0323795925547931 0.0964601634491589 0.553387429160227 0.866666666666667 26.3 26 3 interdigital webbing 0.0323795925547931 0.0964601634491589 0.553387429160227 0.866666666666667 26.3 26 3 absent egg cylinders 0.0323795925547931 0.0964601634491589 0.553387429160227 0.866666666666667 26.3 26 3 abnormal cricoid cartilage morphology 0.0323795925547931 0.0964601634491589 0.553387429160227 0.866666666666667 26.3 26 3 abnormal pericyte morphology 0.0323795925547931 0.0964601634491589 0.553387429160227 0.866666666666667 26.3 26 3 abnormal ear development 0.0323795925547931 0.0964601634491589 0.553387429160227 0.866666666666667 26.3 26 3 abnormal olfactory nerve morphology 0.0323795925547931 0.0964601634491589 0.553387429160227 0.866666666666667 26.3 26 3 absent chorion 0.0323795925547931 0.0964601634491589 0.553387429160227 0.866666666666667 26.3 26 3 bicuspid aortic valve 0.0323795925547931 0.0964601634491589 0.553387429160227 0.866666666666667 26.3 26 3 abnormal microglial cell activation 0.0323795925547931 0.0964601634491589 0.553387429160227 0.866666666666667 26.3 26 3 herniated liver 0.0323795925547931 0.0964601634491589 0.553387429160227 0.866666666666667 26.3 26 3 increased body weight 2.22830640415444e-17 1.24559824277172e-15 0.553007355376463 0.866071428571429 26.3 26 3 internal hemorrhage 4.12228021491403e-06 4.28149145494724e-05 0.552752081939606 0.865671641791045 26.3 26 3 decreased white adipose tissue amount 4.12228021491403e-06 4.28149145494724e-05 0.552752081939606 0.865671641791045 26.3 26 3 cachexia 9.27517102933585e-09 1.57487972255788e-07 0.552568808702889 0.865384615384615 26.3 26 3 increased trabecular bone volume 0.000688458203412569 0.00395505723092093 0.552236935544509 0.864864864864865 26.3 26 3 male infertility 6.41451340935579e-37 1.59561021057725e-34 0.552202626589766 0.864811133200795 26.3 26 3 abnormal thoracic vertebrae morphology 1.74891609979744e-05 0.000160532427979562 0.551944437167632 0.864406779661017 26.3 26 3 increased B cell proliferation 1.74891609979744e-05 0.000160532427979562 0.551944437167632 0.864406779661017 26.3 26 3 increased hemoglobin content 1.74891609979744e-05 0.000160532427979562 0.551944437167632 0.864406779661017 26.3 26 3 teratozoospermia 1.61077121495461e-07 2.24470218330509e-06 0.551452508079247 0.863636363636364 26.3 26 3 osteoporosis 0.000225549052549234 0.00147813013938293 0.551452508079247 0.863636363636364 26.3 26 3 abnormal myelopoiesis 0.000225549052549234 0.00147813013938293 0.551452508079247 0.863636363636364 26.3 26 3 abnormal gametogenesis 0.000225549052549234 0.00147813013938293 0.551452508079247 0.863636363636364 26.3 26 3 abnormal photoreceptor outer segment morphology 0.000225549052549234 0.00147813013938293 0.551452508079247 0.863636363636364 26.3 26 3 decreased sensitivity to induced morbidity/mortality 0.000225549052549234 0.00147813013938293 0.551452508079247 0.863636363636364 26.3 26 3 abnormal long bone epiphysis morphology 0.0097480825901714 0.0369925637930931 0.551452508079247 0.863636363636364 26.3 26 3 abnormal enterocyte morphology 0.0097480825901714 0.0369925637930931 0.551452508079247 0.863636363636364 26.3 26 3 increased activated T cell number 0.0097480825901714 0.0369925637930931 0.551452508079247 0.863636363636364 26.3 26 3 testis hypoplasia 0.0097480825901714 0.0369925637930931 0.551452508079247 0.863636363636364 26.3 26 3 increased skin papilloma incidence 0.0097480825901714 0.0369925637930931 0.551452508079247 0.863636363636364 26.3 26 3 increased myocardial infarction size 0.0097480825901714 0.0369925637930931 0.551452508079247 0.863636363636364 26.3 26 3 decreased cardiac output 0.0097480825901714 0.0369925637930931 0.551452508079247 0.863636363636364 26.3 26 3 parakeratosis 0.0097480825901714 0.0369925637930931 0.551452508079247 0.863636363636364 26.3 26 3 increased bone volume 0.0097480825901714 0.0369925637930931 0.551452508079247 0.863636363636364 26.3 26 3 increased kidney weight 7.46852239106063e-05 0.000576060447992661 0.550883413643665 0.862745098039216 26.3 26 3 abnormal spermiogenesis 2.4927455583297e-05 0.000217568581626145 0.550451686830464 0.862068965517241 26.3 26 3 abnormal enzyme/coenzyme level 2.4927455583297e-05 0.000217568581626145 0.550451686830464 0.862068965517241 26.3 26 3 abnormal embryonic erythropoiesis 0.00305987191254386 0.0139148654158187 0.550451686830464 0.862068965517241 26.3 26 3 increased double-positive T cell number 0.00305987191254386 0.0139148654158187 0.550451686830464 0.862068965517241 26.3 26 3 abnormal double-strand DNA break repair 0.000321675316904444 0.00203088160101473 0.549427590668919 0.86046511627907 26.3 26 3 testicular atrophy 0.000106328297460132 0.00079189113752119 0.549130602782071 0.86 26.3 26 3 increased macrophage cell number 3.54411194881101e-05 0.000296335410845963 0.548906559288484 0.859649122807018 26.3 26 3 abnormal eye electrophysiology 1.52362438886664e-09 2.9494285348683e-08 0.548813979332456 0.859504132231405 26.3 26 3 increased rib number 1.35703696941062e-06 1.55201354547537e-05 0.548475706416201 0.858974358974359 26.3 26 3 increased urine protein level 1.35703696941062e-06 1.55201354547537e-05 0.548475706416201 0.858974358974359 26.3 26 3 liver inflammation 2.15547913998292e-09 4.04660706468492e-08 0.548066396187532 0.858333333333333 26.3 26 3 increased circulating cholesterol level 4.27973316409561e-13 1.43862651968754e-11 0.54782453105241 0.857954545454545 26.3 26 3 small ovary 2.22023564783615e-07 3.02194299005916e-06 0.547306248620005 0.857142857142857 26.3 26 3 increased sarcoma incidence 0.000150942305162111 0.00106971220538676 0.547306248620005 0.857142857142857 26.3 26 3 arrest of spermatogenesis 6.52085122490571e-07 7.97081937196705e-06 0.547306248620004 0.857142857142857 26.3 26 3 decreased exploration in new environment 6.52085122490571e-07 7.97081937196705e-06 0.547306248620004 0.857142857142857 26.3 26 3 abnormal hair follicle morphology 1.68465034828686e-05 0.000155783187411285 0.547306248620004 0.857142857142857 26.3 26 3 abnormal muscle morphology 0.00045726701535852 0.00276080509879689 0.547306248620004 0.857142857142857 26.3 26 3 ovary cysts 0.00140165031613346 0.00728442965411617 0.547306248620004 0.857142857142857 26.3 26 3 abnormal artery morphology 0.00140165031613346 0.00728442965411617 0.547306248620004 0.857142857142857 26.3 26 3 decreased circulating thyroxine level 0.00140165031613346 0.00728442965411617 0.547306248620004 0.857142857142857 26.3 26 3 impaired behavioral response to xenobiotic 0.00140165031613346 0.00728442965411617 0.547306248620004 0.857142857142857 26.3 26 3 impaired adaptive thermogenesis 0.00140165031613346 0.00728442965411617 0.547306248620004 0.857142857142857 26.3 26 3 abnormal stria vascularis morphology 0.00436922767884025 0.018729681894457 0.547306248620004 0.857142857142857 26.3 26 3 corneal vascularization 0.00436922767884025 0.018729681894457 0.547306248620004 0.857142857142857 26.3 26 3 abnormal mitotic spindle morphology 0.00436922767884025 0.018729681894457 0.547306248620004 0.857142857142857 26.3 26 3 abnormal salivary gland morphology 0.0139762229322969 0.0497721611225321 0.547306248620004 0.857142857142857 26.3 26 3 abnormal eye pigmentation 0.0139762229322969 0.0497721611225321 0.547306248620004 0.857142857142857 26.3 26 3 abnormal anxiety-related response 0.0139762229322969 0.0497721611225321 0.547306248620004 0.857142857142857 26.3 26 3 abnormal associative learning 0.0139762229322969 0.0497721611225321 0.547306248620004 0.857142857142857 26.3 26 3 left pulmonary isomerism 0.0139762229322969 0.0497721611225321 0.547306248620004 0.857142857142857 26.3 26 3 increased keratinocyte proliferation 0.0139762229322969 0.0497721611225321 0.547306248620004 0.857142857142857 26.3 26 3 abnormal vasoconstriction 0.0467557291732637 0.133914653216458 0.547306248620004 0.857142857142857 26.3 26 3 abnormal zigzag hair morphology 0.0467557291732637 0.133914653216458 0.547306248620004 0.857142857142857 26.3 26 3 translucent skin 0.0467557291732637 0.133914653216458 0.547306248620004 0.857142857142857 26.3 26 3 extended life span 0.0467557291732637 0.133914653216458 0.547306248620004 0.857142857142857 26.3 26 3 abnormal antigen presentation 0.0467557291732637 0.133914653216458 0.547306248620004 0.857142857142857 26.3 26 3 abnormal endplate potential 0.0467557291732637 0.133914653216458 0.547306248620004 0.857142857142857 26.3 26 3 increased lactate dehydrogenase level 0.0467557291732637 0.133914653216458 0.547306248620004 0.857142857142857 26.3 26 3 abnormal prepulse inhibition 0.0467557291732637 0.133914653216458 0.547306248620004 0.857142857142857 26.3 26 3 premature hair loss 0.0467557291732637 0.133914653216458 0.547306248620004 0.857142857142857 26.3 26 3 abnormal glucose tolerance 0.0467557291732637 0.133914653216458 0.547306248620004 0.857142857142857 26.3 26 3 increased pulmonary respiratory rate 0.0467557291732637 0.133914653216458 0.547306248620004 0.857142857142857 26.3 26 3 pulmonary alveolar hemorrhage 0.0467557291732637 0.133914653216458 0.547306248620004 0.857142857142857 26.3 26 3 absent endolymphatic duct 0.172473568104613 0.33232223134022 0.547306248620004 0.857142857142857 26.3 26 3 growth retardation of molars 0.172473568104613 0.33232223134022 0.547306248620004 0.857142857142857 26.3 26 3 asymmetric rib joints 0.172473568104613 0.33232223134022 0.547306248620004 0.857142857142857 26.3 26 3 cellular necrosis 0.172473568104613 0.33232223134022 0.547306248620004 0.857142857142857 26.3 26 3 absent hair follicles 0.172473568104613 0.33232223134022 0.547306248620004 0.857142857142857 26.3 26 3 maxilla hypoplasia 0.172473568104613 0.33232223134022 0.547306248620004 0.857142857142857 26.3 26 3 abnormal oculomotor nerve morphology 0.172473568104613 0.33232223134022 0.547306248620004 0.857142857142857 26.3 26 3 decreased Schwann cell number 0.172473568104613 0.33232223134022 0.547306248620004 0.857142857142857 26.3 26 3 prostate gland epithelial hyperplasia 0.172473568104613 0.33232223134022 0.547306248620004 0.857142857142857 26.3 26 3 abnormal lacrimal gland morphology 0.172473568104613 0.33232223134022 0.547306248620004 0.857142857142857 26.3 26 3 abnormal vascular permeability 0.172473568104613 0.33232223134022 0.547306248620004 0.857142857142857 26.3 26 3 abnormal axial mesoderm 0.172473568104613 0.33232223134022 0.547306248620004 0.857142857142857 26.3 26 3 increased chemically-elicited antinociception 0.172473568104613 0.33232223134022 0.547306248620004 0.857142857142857 26.3 26 3 abnormal gastrulation movements 0.172473568104613 0.33232223134022 0.547306248620004 0.857142857142857 26.3 26 3 abnormal lymph node primary follicle morphology 0.172473568104613 0.33232223134022 0.547306248620004 0.857142857142857 26.3 26 3 decreased urine calcium level 0.172473568104613 0.33232223134022 0.547306248620004 0.857142857142857 26.3 26 3 decreased mortality induced by ionizing radiation 0.172473568104613 0.33232223134022 0.547306248620004 0.857142857142857 26.3 26 3 abnormal superior semicircular canal morphology 0.172473568104613 0.33232223134022 0.547306248620004 0.857142857142857 26.3 26 3 detached tectorial membrane 0.172473568104613 0.33232223134022 0.547306248620004 0.857142857142857 26.3 26 3 decreased cholesterol efflux 0.172473568104613 0.33232223134022 0.547306248620004 0.857142857142857 26.3 26 3 calcinosis 0.172473568104613 0.33232223134022 0.547306248620004 0.857142857142857 26.3 26 3 abnormal sinus venosus morphology 0.172473568104613 0.33232223134022 0.547306248620004 0.857142857142857 26.3 26 3 aorta coarctation 0.172473568104613 0.33232223134022 0.547306248620004 0.857142857142857 26.3 26 3 increased muscle weight 0.172473568104613 0.33232223134022 0.547306248620004 0.857142857142857 26.3 26 3 abnormal neurotransmitter uptake 0.172473568104613 0.33232223134022 0.547306248620004 0.857142857142857 26.3 26 3 abnormal response to novel odor 0.172473568104613 0.33232223134022 0.547306248620004 0.857142857142857 26.3 26 3 skeletal muscle interstitial fibrosis 0.172473568104613 0.33232223134022 0.547306248620004 0.857142857142857 26.3 26 3 abnormal nephron morphology 0.172473568104613 0.33232223134022 0.547306248620004 0.857142857142857 26.3 26 3 increased ectoderm apoptosis 0.172473568104613 0.33232223134022 0.547306248620004 0.857142857142857 26.3 26 3 renal necrosis 0.172473568104613 0.33232223134022 0.547306248620004 0.857142857142857 26.3 26 3 abnormal vestibular saccular macula morphology 0.172473568104613 0.33232223134022 0.547306248620004 0.857142857142857 26.3 26 3 abnormal cochlear hair cell physiology 0.172473568104613 0.33232223134022 0.547306248620004 0.857142857142857 26.3 26 3 abnormal negative T cell selection 0.172473568104613 0.33232223134022 0.547306248620004 0.857142857142857 26.3 26 3 abnormal MHC II cell surface expression on macrophages 0.172473568104613 0.33232223134022 0.547306248620004 0.857142857142857 26.3 26 3 abnormal ciliary body morphology 0.172473568104613 0.33232223134022 0.547306248620004 0.857142857142857 26.3 26 3 increased thyroid-stimulating hormone level 0.172473568104613 0.33232223134022 0.547306248620004 0.857142857142857 26.3 26 3 absent thyroid gland 0.172473568104613 0.33232223134022 0.547306248620004 0.857142857142857 26.3 26 3 abnormal body temperature 0.172473568104613 0.33232223134022 0.547306248620004 0.857142857142857 26.3 26 3 abnormal renal filtration rate 0.172473568104613 0.33232223134022 0.547306248620004 0.857142857142857 26.3 26 3 abnormal uterus physiology 0.172473568104613 0.33232223134022 0.547306248620004 0.857142857142857 26.3 26 3 abnormal spinal cord central canal morphology 0.172473568104613 0.33232223134022 0.547306248620004 0.857142857142857 26.3 26 3 heart hemorrhage 0.172473568104613 0.33232223134022 0.547306248620004 0.857142857142857 26.3 26 3 enhanced behavioral response to alcohol 0.172473568104613 0.33232223134022 0.547306248620004 0.857142857142857 26.3 26 3 abnormal prostaglandin level 0.172473568104613 0.33232223134022 0.547306248620004 0.857142857142857 26.3 26 3 increased tumor latency 0.172473568104613 0.33232223134022 0.547306248620004 0.857142857142857 26.3 26 3 arteritis 0.172473568104613 0.33232223134022 0.547306248620004 0.857142857142857 26.3 26 3 focal dorsal hair loss 0.172473568104613 0.33232223134022 0.547306248620004 0.857142857142857 26.3 26 3 abnormal retina inner limiting membrane morphology 0.172473568104613 0.33232223134022 0.547306248620004 0.857142857142857 26.3 26 3 heart right ventricle outflow tract stenosis 0.172473568104613 0.33232223134022 0.547306248620004 0.857142857142857 26.3 26 3 abnormal T wave 0.172473568104613 0.33232223134022 0.547306248620004 0.857142857142857 26.3 26 3 thick pulmonary valve 0.172473568104613 0.33232223134022 0.547306248620004 0.857142857142857 26.3 26 3 thick mitral valve cusps 0.172473568104613 0.33232223134022 0.547306248620004 0.857142857142857 26.3 26 3 altered tumor pathology 0.172473568104613 0.33232223134022 0.547306248620004 0.857142857142857 26.3 26 3 abnormal impulsive behavior control 0.172473568104613 0.33232223134022 0.547306248620004 0.857142857142857 26.3 26 3 increased right ventricle systolic pressure 0.172473568104613 0.33232223134022 0.547306248620004 0.857142857142857 26.3 26 3 increased compact bone volume 0.172473568104613 0.33232223134022 0.547306248620004 0.857142857142857 26.3 26 3 impaired branching involved in bronchus morphogenesis 0.172473568104613 0.33232223134022 0.547306248620004 0.857142857142857 26.3 26 3 abnormal brain ependyma motile cilium physiology 0.172473568104613 0.33232223134022 0.547306248620004 0.857142857142857 26.3 26 3 embryonic lethality at implantation, incomplete penetrance 0.172473568104613 0.33232223134022 0.547306248620004 0.857142857142857 26.3 26 3 increased circulating lactate dehydrogenase level 0.172473568104613 0.33232223134022 0.547306248620004 0.857142857142857 26.3 26 3 parturition failure 0.172473568104613 0.33232223134022 0.547306248620004 0.857142857142857 26.3 26 3 impaired mammary gland growth during pregnancy 0.172473568104613 0.33232223134022 0.547306248620004 0.857142857142857 26.3 26 3 embryo tumor 0.172473568104613 0.33232223134022 0.547306248620004 0.857142857142857 26.3 26 3 decreased collagen level 0.172473568104613 0.33232223134022 0.547306248620004 0.857142857142857 26.3 26 3 decreased IgG level 1.252627681816e-08 2.03654337157994e-07 0.54648446746592 0.855855855855856 26.3 26 3 increased circulating calcium level 7.10844966134887e-05 0.000558681470224496 0.545647744836308 0.854545454545454 26.3 26 3 decreased circulating calcium level 7.10844966134887e-05 0.000558681470224496 0.545647744836308 0.854545454545454 26.3 26 3 abnormal intestinal epithelium morphology 0.000213634052767753 0.00143045681361988 0.545405879701185 0.854166666666667 26.3 26 3 abnormal osteoclast morphology 0.000213634052767753 0.00143045681361988 0.545405879701185 0.854166666666667 26.3 26 3 decreased litter size 1.97839499116796e-19 1.51423308939394e-17 0.545358539550182 0.854092526690391 26.3 26 3 liver fibrosis 0.000647784958462582 0.00374736066087366 0.545081426471143 0.853658536585366 26.3 26 3 increased bone trabecula number 0.000647784958462582 0.00374736066087366 0.545081426471143 0.853658536585366 26.3 26 3 abnormal oocyte morphology 0.00198814824765988 0.00970661190589587 0.544623374852259 0.852941176470588 26.3 26 3 abnormal spleen red pulp morphology 0.00198814824765988 0.00970661190589587 0.544623374852259 0.852941176470588 26.3 26 3 decreased pancreatic beta cell number 0.00198814824765988 0.00970661190589587 0.544623374852259 0.852941176470588 26.3 26 3 increased width of hypertrophic chondrocyte zone 0.00198814824765988 0.00970661190589587 0.544623374852259 0.852941176470588 26.3 26 3 rectal prolapse 0.00620867685113981 0.0261100315591044 0.543927814986548 0.851851851851852 26.3 26 3 wrinkled skin 0.00620867685113981 0.0261100315591044 0.543927814986548 0.851851851851852 26.3 26 3 abnormal lens morphology 1.98516244419543e-09 3.78606721136214e-08 0.543743056897218 0.8515625 26.3 26 3 small seminiferous tubules 5.37885201796745e-06 5.45005881657598e-05 0.543608233426626 0.851351351351351 26.3 26 3 increased systemic arterial blood pressure 0.000301421157673864 0.00191028058525793 0.543424644019863 0.851063829787234 26.3 26 3 decreased T cell number 1.90370089181885e-11 4.83209792693816e-10 0.543340261311164 0.850931677018634 26.3 26 3 decreased circulating phosphate level 0.000914385760044737 0.00503464748103651 0.542745363214838 0.85 26.3 26 3 abnormal skin pigmentation 0.000914385760044737 0.00503464748103651 0.542745363214838 0.85 26.3 26 3 abnormal pancreatic beta cell morphology 0.000914385760044737 0.00503464748103651 0.542745363214838 0.85 26.3 26 3 increased susceptibility to weight loss 0.000914385760044737 0.00503464748103651 0.542745363214838 0.85 26.3 26 3 abnormal circulating enzyme level 0.0199156317543625 0.0650559868535478 0.542745363214838 0.85 26.3 26 3 increased urine glucose level 0.0199156317543625 0.0650559868535478 0.542745363214838 0.85 26.3 26 3 decreased myocardial infarction size 0.0199156317543625 0.0650559868535478 0.542745363214838 0.85 26.3 26 3 abnormal physiological neovascularization 0.0199156317543625 0.0650559868535478 0.542745363214838 0.85 26.3 26 3 abnormal response to tactile stimuli 0.0199156317543625 0.0650559868535478 0.542745363214838 0.85 26.3 26 3 enhanced behavioral response to xenobiotic 0.0199156317543625 0.0650559868535478 0.542745363214838 0.85 26.3 26 3 abnormal sperm mitochondrial sheath morphology 0.0199156317543625 0.0650559868535478 0.542745363214838 0.85 26.3 26 3 abnormal skin morphology 2.23167845776436e-05 0.000195468315622847 0.541777902674348 0.848484848484849 26.3 26 3 abnormal tail morphology 2.23167845776436e-05 0.000195468315622847 0.541777902674348 0.848484848484849 26.3 26 3 abnormal epidermis stratum basale morphology 0.00280810436626781 0.0127933326210461 0.541777902674348 0.848484848484849 26.3 26 3 absent vibrissae 0.00280810436626781 0.0127933326210461 0.541777902674348 0.848484848484849 26.3 26 3 decreased systemic arterial blood pressure 0.00280810436626781 0.0127933326210461 0.541777902674348 0.848484848484849 26.3 26 3 cardiovascular system phenotype 0.00280810436626781 0.0127933326210461 0.541777902674348 0.848484848484849 26.3 26 3 improved glucose tolerance 3.41328154364421e-13 1.18748780976433e-11 0.540790698041195 0.846938775510204 26.3 26 3 decreased neutrophil cell number 2.20750617650176e-08 3.47798734329316e-07 0.540289501842825 0.846153846153846 26.3 26 3 decreased circulating glycerol level 0.00877682807522999 0.033901179871327 0.540289501842825 0.846153846153846 26.3 26 3 pulmonary edema 0.00877682807522999 0.033901179871327 0.540289501842825 0.846153846153846 26.3 26 3 abnormal membranous labyrinth morphology 0.0669486774883876 0.172218030250635 0.540289501842825 0.846153846153846 26.3 26 3 short premaxilla 0.0669486774883876 0.172218030250635 0.540289501842825 0.846153846153846 26.3 26 3 abnormal renal/urinary system morphology 0.0669486774883876 0.172218030250635 0.540289501842825 0.846153846153846 26.3 26 3 increased foot pad pigmentation 0.0669486774883876 0.172218030250635 0.540289501842825 0.846153846153846 26.3 26 3 small trigeminal ganglion 0.0669486774883876 0.172218030250635 0.540289501842825 0.846153846153846 26.3 26 3 abnormal digestion 0.0669486774883876 0.172218030250635 0.540289501842825 0.846153846153846 26.3 26 3 increased pituitary adenoma incidence 0.0669486774883876 0.172218030250635 0.540289501842825 0.846153846153846 26.3 26 3 lymphoid hypoplasia 0.0669486774883876 0.172218030250635 0.540289501842825 0.846153846153846 26.3 26 3 abnormal intercostal muscle morphology 0.0669486774883876 0.172218030250635 0.540289501842825 0.846153846153846 26.3 26 3 abnormal bile duct development 0.0669486774883876 0.172218030250635 0.540289501842825 0.846153846153846 26.3 26 3 abnormal dopaminergic neuron morphology 0.0669486774883876 0.172218030250635 0.540289501842825 0.846153846153846 26.3 26 3 decreased endocochlear potential 0.0669486774883876 0.172218030250635 0.540289501842825 0.846153846153846 26.3 26 3 increased circulating thyroid-stimulating hormone level 0.0669486774883876 0.172218030250635 0.540289501842825 0.846153846153846 26.3 26 3 increased circulating ammonia level 0.0669486774883876 0.172218030250635 0.540289501842825 0.846153846153846 26.3 26 3 increased circulating thyroxine level 0.0669486774883876 0.172218030250635 0.540289501842825 0.846153846153846 26.3 26 3 orthokeratosis 0.0669486774883876 0.172218030250635 0.540289501842825 0.846153846153846 26.3 26 3 empty decidua capsularis 0.0669486774883876 0.172218030250635 0.540289501842825 0.846153846153846 26.3 26 3 abnormal aorta tunica media morphology 0.0669486774883876 0.172218030250635 0.540289501842825 0.846153846153846 26.3 26 3 decreased cardiac stroke volume 0.0669486774883876 0.172218030250635 0.540289501842825 0.846153846153846 26.3 26 3 impaired macrophage chemotaxis 0.00128584705009786 0.00676940642776389 0.540289501842825 0.846153846153846 26.3 26 3 decreased inflammatory response 2.38838464727974e-06 2.60004674402992e-05 0.539704772944727 0.845238095238095 26.3 26 3 increased circulating glucose level 1.17910653008253e-09 2.33707370006398e-08 0.538896105319697 0.843971631205674 26.3 26 3 failure of primitive streak formation 0.0039484370134937 0.0176332801993996 0.538754588485317 0.84375 26.3 26 3 increased circulating follicle stimulating hormone level 0.0039484370134937 0.0176332801993996 0.538754588485317 0.84375 26.3 26 3 increased dopamine level 0.0039484370134937 0.0176332801993996 0.538754588485317 0.84375 26.3 26 3 abnormal lumbar vertebrae morphology 0.0039484370134937 0.0176332801993996 0.538754588485317 0.84375 26.3 26 3 increased sensitivity to induced morbidity/mortality 5.12039501742544e-12 1.48970556793518e-10 0.537887028761508 0.842391304347826 26.3 26 3 decreased susceptibility to induced arthritis 0.000129291959264289 0.00094314882307894 0.537704384609127 0.842105263157895 26.3 26 3 increased bone marrow cell number 0.00180106132711304 0.00886278941878079 0.537704384609127 0.842105263157895 26.3 26 3 abnormal reproductive system physiology 0.00180106132711304 0.00886278941878079 0.537704384609127 0.842105263157895 26.3 26 3 hyporesponsive to tactile stimuli 0.00180106132711304 0.00886278941878079 0.537704384609127 0.842105263157895 26.3 26 3 irregular coat pigmentation 0.02818923283701 0.0885362584369474 0.537704384609127 0.842105263157895 26.3 26 3 shiny skin 0.02818923283701 0.0885362584369474 0.537704384609127 0.842105263157895 26.3 26 3 thin dermal layer 0.02818923283701 0.0885362584369474 0.537704384609127 0.842105263157895 26.3 26 3 decreased chemically-elicited antinociception 0.02818923283701 0.0885362584369474 0.537704384609127 0.842105263157895 26.3 26 3 abnormal response to novelty 0.02818923283701 0.0885362584369474 0.537704384609127 0.842105263157895 26.3 26 3 abnormal photoreceptor inner segment morphology 0.02818923283701 0.0885362584369474 0.537704384609127 0.842105263157895 26.3 26 3 absent amnion 0.02818923283701 0.0885362584369474 0.537704384609127 0.842105263157895 26.3 26 3 decreased eye pigmentation 0.02818923283701 0.0885362584369474 0.537704384609127 0.842105263157895 26.3 26 3 decreased circulating magnesium level 0.02818923283701 0.0885362584369474 0.537704384609127 0.842105263157895 26.3 26 3 decreased susceptibility to weight gain 0.02818923283701 0.0885362584369474 0.537704384609127 0.842105263157895 26.3 26 3 right-sided stomach 0.02818923283701 0.0885362584369474 0.537704384609127 0.842105263157895 26.3 26 3 increased leukocyte cell number 1.09309036140656e-09 2.17524981919905e-08 0.537240846346533 0.841379310344828 26.3 26 3 hyperglycemia 2.20015974170548e-06 2.40566916812852e-05 0.536940599971898 0.840909090909091 26.3 26 3 increased liver weight 2.20015974170548e-06 2.40566916812852e-05 0.536940599971898 0.840909090909091 26.3 26 3 increased spleen weight 8.24686586401444e-08 1.22472112458125e-06 0.536812176006346 0.84070796460177 26.3 26 3 abnormal sternum morphology 2.86374619029576e-05 0.000244376282962631 0.536730282463096 0.840579710144927 26.3 26 3 abnormal epidermal layer morphology 2.86374619029576e-05 0.000244376282962631 0.536730282463096 0.840579710144927 26.3 26 3 increased lymphocyte cell number 2.86374619029576e-05 0.000244376282962631 0.536730282463096 0.840579710144927 26.3 26 3 abnormal digestive system physiology 0.000385165845597508 0.0023656791133921 0.536360123647604 0.84 26.3 26 3 increased circulating chloride level 0.000385165845597508 0.0023656791133921 0.536360123647604 0.84 26.3 26 3 increased pre-B cell number 0.0123383077450305 0.0441922829600625 0.536360123647604 0.84 26.3 26 3 abnormal seminal vesicle morphology 0.000179836352546367 0.00123404945368024 0.535904035107088 0.839285714285714 26.3 26 3 absent mature ovarian follicles 0.00552544542846682 0.02331559881817 0.535536221767961 0.838709677419355 26.3 26 3 abnormal CD8-positive, alpha beta T cell morphology 0.00552544542846682 0.02331559881817 0.535536221767961 0.838709677419355 26.3 26 3 decreased double-negative T cell number 0.00552544542846682 0.02331559881817 0.535536221767961 0.838709677419355 26.3 26 3 decreased T cell proliferation 1.39077941102518e-09 2.72406597238199e-08 0.534979531308743 0.837837837837838 26.3 26 3 increased granulocyte number 1.87652990066312e-05 0.000169125656807953 0.534979531308743 0.837837837837838 26.3 26 3 increased insulin secretion 0.0025122274702262 0.0119830600808968 0.534979531308743 0.837837837837838 26.3 26 3 abnormal pancreatic beta cell physiology 0.0025122274702262 0.0119830600808968 0.534979531308743 0.837837837837838 26.3 26 3 abnormal male reproductive system morphology 0.00115459575026519 0.00609131904302153 0.534578196326516 0.837209302325581 26.3 26 3 decreased oxygen consumption 0.00115459575026519 0.00609131904302153 0.534578196326516 0.837209302325581 26.3 26 3 increased fluid intake 0.000534929259246662 0.00318715337096065 0.534275147462385 0.836734693877551 26.3 26 3 abnormal rostral-caudal axis patterning 0.000249384264673835 0.00162819779101356 0.534038218350429 0.836363636363636 26.3 26 3 decreased food intake 1.22780583366835e-05 0.000115034539030133 0.533450394224561 0.835443037974684 26.3 26 3 decreased IgM level 1.31870583808471e-06 1.51514123428901e-05 0.533200417470004 0.835051546391753 26.3 26 3 abnormal cardiovascular system morphology 0.000740356682204433 0.00414316590997419 0.532103297269449 0.833333333333333 26.3 26 3 abnormal cytotoxic T cell physiology 0.00160037467398292 0.00820260469898873 0.532103297269449 0.833333333333333 26.3 26 3 abnormal uterus morphology 0.00348887904178095 0.0156511931766097 0.532103297269449 0.833333333333333 26.3 26 3 head tilt 0.00348887904178095 0.0156511931766097 0.532103297269449 0.833333333333333 26.3 26 3 abnormal hair cycle 0.00769328002679825 0.0297621058579481 0.532103297269449 0.833333333333333 26.3 26 3 delayed eyelid opening 0.00769328002679825 0.0297621058579481 0.532103297269449 0.833333333333333 26.3 26 3 liver hemorrhage 0.00769328002679825 0.0297621058579481 0.532103297269449 0.833333333333333 26.3 26 3 abnormal cellular respiration 0.00769328002679825 0.0297621058579481 0.532103297269449 0.833333333333333 26.3 26 3 abnormal sensory capabilities/reflexes/nociception 0.0172413102317023 0.0600248554252755 0.532103297269449 0.833333333333333 26.3 26 3 abnormal primitive streak formation 0.0172413102317023 0.0600248554252755 0.532103297269449 0.833333333333333 26.3 26 3 abnormal inner cell mass apoptosis 0.0172413102317023 0.0600248554252755 0.532103297269449 0.833333333333333 26.3 26 3 abnormal megakaryocyte differentiation 0.0396071058366836 0.114561250893896 0.532103297269449 0.833333333333333 26.3 26 3 abnormal stomach glandular epithelium morphology 0.0396071058366836 0.114561250893896 0.532103297269449 0.833333333333333 26.3 26 3 absent spleen 0.0396071058366836 0.114561250893896 0.532103297269449 0.833333333333333 26.3 26 3 abnormal anterior eye segment morphology 0.0396071058366836 0.114561250893896 0.532103297269449 0.833333333333333 26.3 26 3 abnormal glycogen homeostasis 0.0396071058366836 0.114561250893896 0.532103297269449 0.833333333333333 26.3 26 3 decreased tumor latency 0.0396071058366836 0.114561250893896 0.532103297269449 0.833333333333333 26.3 26 3 mesocardia 0.0949478514349641 0.216980046343108 0.532103297269449 0.833333333333333 26.3 26 3 ear inflammation 0.0949478514349641 0.216980046343108 0.532103297269449 0.833333333333333 26.3 26 3 altered tumor susceptibility 0.0949478514349641 0.216980046343108 0.532103297269449 0.833333333333333 26.3 26 3 increased circulating parathyroid hormone level 0.0949478514349641 0.216980046343108 0.532103297269449 0.833333333333333 26.3 26 3 abnormal gastrocnemius morphology 0.0949478514349641 0.216980046343108 0.532103297269449 0.833333333333333 26.3 26 3 dilated bile duct 0.0949478514349641 0.216980046343108 0.532103297269449 0.833333333333333 26.3 26 3 small intestinal inflammation 0.0949478514349641 0.216980046343108 0.532103297269449 0.833333333333333 26.3 26 3 delayed somite formation 0.0949478514349641 0.216980046343108 0.532103297269449 0.833333333333333 26.3 26 3 bowed ulna 0.0949478514349641 0.216980046343108 0.532103297269449 0.833333333333333 26.3 26 3 absent cochlear hair cells 0.0949478514349641 0.216980046343108 0.532103297269449 0.833333333333333 26.3 26 3 abnormal B cell proliferation 0.0949478514349641 0.216980046343108 0.532103297269449 0.833333333333333 26.3 26 3 abnormal amacrine cell morphology 0.0949478514349641 0.216980046343108 0.532103297269449 0.833333333333333 26.3 26 3 hemoperitoneum 0.0949478514349641 0.216980046343108 0.532103297269449 0.833333333333333 26.3 26 3 abnormal thymus corticomedullary boundary morphology 0.0949478514349641 0.216980046343108 0.532103297269449 0.833333333333333 26.3 26 3 reduced cerebellar foliation 0.0949478514349641 0.216980046343108 0.532103297269449 0.833333333333333 26.3 26 3 abnormal behavioral response to addictive substance 0.0949478514349641 0.216980046343108 0.532103297269449 0.833333333333333 26.3 26 3 decreased oligodendrocyte number 0.0949478514349641 0.216980046343108 0.532103297269449 0.833333333333333 26.3 26 3 abnormal aorta elastic tissue morphology 0.0949478514349641 0.216980046343108 0.532103297269449 0.833333333333333 26.3 26 3 decreased mammary gland epithelial cell proliferation 0.0949478514349641 0.216980046343108 0.532103297269449 0.833333333333333 26.3 26 3 abnormal respiratory motile cilium morphology 0.0949478514349641 0.216980046343108 0.532103297269449 0.833333333333333 26.3 26 3 decreased compensatory feeding amount 0.0949478514349641 0.216980046343108 0.532103297269449 0.833333333333333 26.3 26 3 absent limbs 0.249628252901441 0.413578071406928 0.532103297269449 0.833333333333333 26.3 26 3 constricted vagina orifice 0.249628252901441 0.413578071406928 0.532103297269449 0.833333333333333 26.3 26 3 epidermal necrosis 0.249628252901441 0.413578071406928 0.532103297269449 0.833333333333333 26.3 26 3 abnormal lens induction 0.249628252901441 0.413578071406928 0.532103297269449 0.833333333333333 26.3 26 3 abnormal avoidance learning behavior 0.249628252901441 0.413578071406928 0.532103297269449 0.833333333333333 26.3 26 3 abnormal chemically-elicited antinociception 0.249628252901441 0.413578071406928 0.532103297269449 0.833333333333333 26.3 26 3 abnormal parental behavior 0.249628252901441 0.413578071406928 0.532103297269449 0.833333333333333 26.3 26 3 abnormal hepatobiliary system physiology 0.249628252901441 0.413578071406928 0.532103297269449 0.833333333333333 26.3 26 3 abnormal blood gas level 0.249628252901441 0.413578071406928 0.532103297269449 0.833333333333333 26.3 26 3 abnormal lymph node cortex morphology 0.249628252901441 0.413578071406928 0.532103297269449 0.833333333333333 26.3 26 3 abnormal otolithic membrane morphology 0.249628252901441 0.413578071406928 0.532103297269449 0.833333333333333 26.3 26 3 aganglionic megacolon 0.249628252901441 0.413578071406928 0.532103297269449 0.833333333333333 26.3 26 3 ectopic thymus 0.249628252901441 0.413578071406928 0.532103297269449 0.833333333333333 26.3 26 3 liver cirrhosis 0.249628252901441 0.413578071406928 0.532103297269449 0.833333333333333 26.3 26 3 decreased otolith number 0.249628252901441 0.413578071406928 0.532103297269449 0.833333333333333 26.3 26 3 extremity edema 0.249628252901441 0.413578071406928 0.532103297269449 0.833333333333333 26.3 26 3 abnormal glutaminergic neuron morphology 0.249628252901441 0.413578071406928 0.532103297269449 0.833333333333333 26.3 26 3 bile duct inflammation 0.249628252901441 0.413578071406928 0.532103297269449 0.833333333333333 26.3 26 3 impaired granulosa cell differentiation 0.249628252901441 0.413578071406928 0.532103297269449 0.833333333333333 26.3 26 3 abnormal periodontal ligament morphology 0.249628252901441 0.413578071406928 0.532103297269449 0.833333333333333 26.3 26 3 fusion of middle ear ossicles 0.249628252901441 0.413578071406928 0.532103297269449 0.833333333333333 26.3 26 3 abnormal serotonergic neuron morphology 0.249628252901441 0.413578071406928 0.532103297269449 0.833333333333333 26.3 26 3 abnormal cholesterol level 0.249628252901441 0.413578071406928 0.532103297269449 0.833333333333333 26.3 26 3 absent cochlear inner hair cells 0.249628252901441 0.413578071406928 0.532103297269449 0.833333333333333 26.3 26 3 decreased cochlear microphonics 0.249628252901441 0.413578071406928 0.532103297269449 0.833333333333333 26.3 26 3 abnormal blastocoele morphology 0.249628252901441 0.413578071406928 0.532103297269449 0.833333333333333 26.3 26 3 abnormal anus morphology 0.249628252901441 0.413578071406928 0.532103297269449 0.833333333333333 26.3 26 3 impaired granulocyte bactericidal activity 0.249628252901441 0.413578071406928 0.532103297269449 0.833333333333333 26.3 26 3 variegated coat color 0.249628252901441 0.413578071406928 0.532103297269449 0.833333333333333 26.3 26 3 abnormal heart size 0.249628252901441 0.413578071406928 0.532103297269449 0.833333333333333 26.3 26 3 decreased triiodothyronine level 0.249628252901441 0.413578071406928 0.532103297269449 0.833333333333333 26.3 26 3 abnormal pulmonary respiratory rate 0.249628252901441 0.413578071406928 0.532103297269449 0.833333333333333 26.3 26 3 absent brachial lymph nodes 0.249628252901441 0.413578071406928 0.532103297269449 0.833333333333333 26.3 26 3 abnormal neural crest cell morphology 0.249628252901441 0.413578071406928 0.532103297269449 0.833333333333333 26.3 26 3 exostosis 0.249628252901441 0.413578071406928 0.532103297269449 0.833333333333333 26.3 26 3 absent tongue 0.249628252901441 0.413578071406928 0.532103297269449 0.833333333333333 26.3 26 3 variable depigmentation 0.249628252901441 0.413578071406928 0.532103297269449 0.833333333333333 26.3 26 3 visceral vascular congestion 0.249628252901441 0.413578071406928 0.532103297269449 0.833333333333333 26.3 26 3 abnormal renal water reabsorbtion 0.249628252901441 0.413578071406928 0.532103297269449 0.833333333333333 26.3 26 3 abnormal bone mineral density 0.249628252901441 0.413578071406928 0.532103297269449 0.833333333333333 26.3 26 3 decreased DN1 thymic pro-T cell number 0.249628252901441 0.413578071406928 0.532103297269449 0.833333333333333 26.3 26 3 abnormal synaptic dopamine release 0.249628252901441 0.413578071406928 0.532103297269449 0.833333333333333 26.3 26 3 abnormal epiglottis morphology 0.249628252901441 0.413578071406928 0.532103297269449 0.833333333333333 26.3 26 3 abnormal heart right ventricle outflow tract morphology 0.249628252901441 0.413578071406928 0.532103297269449 0.833333333333333 26.3 26 3 thick pulmonary valve cusps 0.249628252901441 0.413578071406928 0.532103297269449 0.833333333333333 26.3 26 3 absent alveolar lamellar bodies 0.249628252901441 0.413578071406928 0.532103297269449 0.833333333333333 26.3 26 3 decreased macrophage nitric oxide production 0.249628252901441 0.413578071406928 0.532103297269449 0.833333333333333 26.3 26 3 increased macrophage apoptosis 0.249628252901441 0.413578071406928 0.532103297269449 0.833333333333333 26.3 26 3 abnormal circulating osteocalcin level 0.249628252901441 0.413578071406928 0.532103297269449 0.833333333333333 26.3 26 3 absent midbrain 0.249628252901441 0.413578071406928 0.532103297269449 0.833333333333333 26.3 26 3 thymus cortex atrophy 0.249628252901441 0.413578071406928 0.532103297269449 0.833333333333333 26.3 26 3 absent thymus corticomedullary boundary 0.249628252901441 0.413578071406928 0.532103297269449 0.833333333333333 26.3 26 3 ciliary body hypoplasia 0.249628252901441 0.413578071406928 0.532103297269449 0.833333333333333 26.3 26 3 increased male germ cell apoptosis 0.249628252901441 0.413578071406928 0.532103297269449 0.833333333333333 26.3 26 3 abnormal platelet alpha-granule morphology 0.249628252901441 0.413578071406928 0.532103297269449 0.833333333333333 26.3 26 3 increased pancreatic beta cell apoptosis 0.249628252901441 0.413578071406928 0.532103297269449 0.833333333333333 26.3 26 3 increased pancreatic islet cell apoptosis 0.249628252901441 0.413578071406928 0.532103297269449 0.833333333333333 26.3 26 3 abnormal embryo morphology 0.249628252901441 0.413578071406928 0.532103297269449 0.833333333333333 26.3 26 3 abnormal inhibitory learning 0.249628252901441 0.413578071406928 0.532103297269449 0.833333333333333 26.3 26 3 abnormal colon morphology 0.000222193412785848 0.00147813013938293 0.530299557278705 0.830508474576271 26.3 26 3 abnormal placenta development 0.000475025058875373 0.00286107707978811 0.530095360298621 0.830188679245283 26.3 26 3 abnormal T-helper 1 physiology 0.00102098654671436 0.00547715362888855 0.529839027919366 0.829787234042553 26.3 26 3 abnormal cholesterol homeostasis 0.00220930393915804 0.0105787171292698 0.52950767142911 0.829268292682927 26.3 26 3 increased B cell number 2.43435190637482e-07 3.26439372889885e-06 0.529374562411657 0.829059829059829 26.3 26 3 abnormal intestinal goblet cell morphology 0.00482288825003756 0.0204203140799462 0.529062706999338 0.828571428571429 26.3 26 3 dermatitis 0.000305018906810836 0.00193062221550116 0.528433619357246 0.827586206896552 26.3 26 3 abnormal circulating glucose level 0.0106541353570629 0.0395259682336971 0.528433619357246 0.827586206896552 26.3 26 3 decreased trophoblast giant cell number 0.0106541353570629 0.0395259682336971 0.528433619357246 0.827586206896552 26.3 26 3 decreased bone strength 0.0106541353570629 0.0395259682336971 0.528433619357246 0.827586206896552 26.3 26 3 polychromatophilia 0.0106541353570629 0.0395259682336971 0.528433619357246 0.827586206896552 26.3 26 3 absent corpus luteum 0.000652333511112998 0.00376055529291676 0.528010194982761 0.826923076923077 26.3 26 3 abnormal leukocyte migration 0.000652333511112998 0.00376055529291676 0.528010194982761 0.826923076923077 26.3 26 3 decreased body temperature 0.000652333511112998 0.00376055529291676 0.528010194982761 0.826923076923077 26.3 26 3 delayed wound healing 0.00140271027309413 0.00728442965411617 0.527476312075801 0.826086956521739 26.3 26 3 skin lesions 0.000196018841786727 0.00132499149169697 0.527035646819264 0.825396825396825 26.3 26 3 abnormal trabecular bone morphology 4.0240191165601e-07 5.18639769556645e-06 0.525843258478043 0.823529411764706 26.3 26 3 abnormal cervical vertebrae morphology 0.000892693975371318 0.00498445850445825 0.525843258478043 0.823529411764706 26.3 26 3 abnormal bone remodeling 0.00663456625310481 0.0273916739495406 0.525843258478043 0.823529411764706 26.3 26 3 increased susceptibility to weight gain 0.00663456625310481 0.0273916739495406 0.525843258478043 0.823529411764706 26.3 26 3 abnormal urinary bladder morphology 0.0551997593700705 0.143704240118316 0.525843258478043 0.823529411764706 26.3 26 3 increased incidence of corneal inflammation 0.0551997593700705 0.143704240118316 0.525843258478043 0.823529411764706 26.3 26 3 abnormal testis development 0.0551997593700705 0.143704240118316 0.525843258478043 0.823529411764706 26.3 26 3 pancytopenia 0.0551997593700705 0.143704240118316 0.525843258478043 0.823529411764706 26.3 26 3 abnormal circulating chemokine level 0.0551997593700705 0.143704240118316 0.525843258478043 0.823529411764706 26.3 26 3 increased hepatoma incidence 0.0551997593700705 0.143704240118316 0.525843258478043 0.823529411764706 26.3 26 3 abnormal electroretinogram waveform feature 0.0551997593700705 0.143704240118316 0.525843258478043 0.823529411764706 26.3 26 3 decreased body fat mass 0.0551997593700705 0.143704240118316 0.525843258478043 0.823529411764706 26.3 26 3 abnormal cell cytoskeleton morphology 0.0551997593700705 0.143704240118316 0.525843258478043 0.823529411764706 26.3 26 3 reddish skin 0.0146701430437178 0.0522059811462777 0.524501821594171 0.821428571428571 26.3 26 3 maternal effect 0.000171562901617978 0.00117890253528928 0.524161457011696 0.82089552238806 26.3 26 3 increased autoantibody level 0.00415632659346819 0.0182826921330718 0.523917092696073 0.82051282051282 26.3 26 3 increased body length 0.00121718481031502 0.00641471867724285 0.523589644513138 0.82 26.3 26 3 abnormal male meiosis 0.000363740543240735 0.00227591310418618 0.523380292396179 0.819672131147541 26.3 26 3 abnormal T-helper 2 physiology 0.000773871601180348 0.00432585529873284 0.52242869186455 0.818181818181818 26.3 26 3 decreased macrophage cell number 0.00261630584108242 0.0122337633611439 0.52242869186455 0.818181818181818 26.3 26 3 abnormal T cell subpopulation ratio 0.0090799339260102 0.0350175746371323 0.52242869186455 0.818181818181818 26.3 26 3 diarrhea 0.0090799339260102 0.0350175746371323 0.52242869186455 0.818181818181818 26.3 26 3 abnormal abdominal fat pad morphology 0.0330028544718617 0.0979649170629545 0.52242869186455 0.818181818181818 26.3 26 3 abnormal germ layer development 0.0330028544718617 0.0979649170629545 0.52242869186455 0.818181818181818 26.3 26 3 abnormal chorion morphology 0.0330028544718617 0.0979649170629545 0.52242869186455 0.818181818181818 26.3 26 3 increased coping response 0.0330028544718617 0.0979649170629545 0.52242869186455 0.818181818181818 26.3 26 3 abnormal female reproductive system physiology 0.0330028544718617 0.0979649170629545 0.52242869186455 0.818181818181818 26.3 26 3 abnormal retinal outer plexiform layer morphology 0.0330028544718617 0.0979649170629545 0.52242869186455 0.818181818181818 26.3 26 3 abnormal ear position 0.133182045961673 0.276717358331809 0.52242869186455 0.818181818181818 26.3 26 3 abnormal thrombopoiesis 0.133182045961673 0.276717358331809 0.52242869186455 0.818181818181818 26.3 26 3 abnormal large intestine morphology 0.133182045961673 0.276717358331809 0.52242869186455 0.818181818181818 26.3 26 3 focal hepatic necrosis 0.133182045961673 0.276717358331809 0.52242869186455 0.818181818181818 26.3 26 3 vasculitis 0.133182045961673 0.276717358331809 0.52242869186455 0.818181818181818 26.3 26 3 abnormal fear/anxiety-related behavior 0.133182045961673 0.276717358331809 0.52242869186455 0.818181818181818 26.3 26 3 abnormal larynx morphology 0.133182045961673 0.276717358331809 0.52242869186455 0.818181818181818 26.3 26 3 decreased post-tetanic potentiation 0.133182045961673 0.276717358331809 0.52242869186455 0.818181818181818 26.3 26 3 rectal hemorrhage 0.133182045961673 0.276717358331809 0.52242869186455 0.818181818181818 26.3 26 3 impaired luteinization 0.133182045961673 0.276717358331809 0.52242869186455 0.818181818181818 26.3 26 3 abnormal nerve fiber response 0.133182045961673 0.276717358331809 0.52242869186455 0.818181818181818 26.3 26 3 pathological neovascularization 0.133182045961673 0.276717358331809 0.52242869186455 0.818181818181818 26.3 26 3 enlarged placenta 0.133182045961673 0.276717358331809 0.52242869186455 0.818181818181818 26.3 26 3 increased circulating triiodothyronine level 0.133182045961673 0.276717358331809 0.52242869186455 0.818181818181818 26.3 26 3 increased number of Howell-Jolly bodies 0.133182045961673 0.276717358331809 0.52242869186455 0.818181818181818 26.3 26 3 increased subcutaneous adipose tissue amount 0.133182045961673 0.276717358331809 0.52242869186455 0.818181818181818 26.3 26 3 decreased colon length 0.133182045961673 0.276717358331809 0.52242869186455 0.818181818181818 26.3 26 3 abnormal eye physiology 0.000493161725122877 0.00294535364043975 0.52146123132406 0.816666666666667 26.3 26 3 abnormal compact bone morphology 0.00566167753258444 0.0238702082411929 0.520901122590092 0.815789473684211 26.3 26 3 polyphagia 0.00104825468415694 0.00560157578268609 0.52027877955235 0.814814814814815 26.3 26 3 increased brain weight 0.0200766934612267 0.0653675065246093 0.52027877955235 0.814814814814815 26.3 26 3 abnormal type II pneumocyte morphology 0.0200766934612267 0.0653675065246093 0.52027877955235 0.814814814814815 26.3 26 3 cryptorchism 0.0200766934612267 0.0653675065246093 0.52027877955235 0.814814814814815 26.3 26 3 abnormal single cell response 0.0200766934612267 0.0653675065246093 0.52027877955235 0.814814814814815 26.3 26 3 thick epidermis 0.000201439844774073 0.00135978728324425 0.519940936189004 0.814285714285714 26.3 26 3 impaired macrophage phagocytosis 0.00355065746524798 0.0159139827834312 0.519728801984113 0.813953488372093 26.3 26 3 decreased eosinophil cell number 0.000424694906732444 0.00258928573651214 0.518800714837713 0.8125 26.3 26 3 abnormal crypts of Lieberkuhn morphology 0.012359148560017 0.0442350820763199 0.518800714837713 0.8125 26.3 26 3 abnormal mouth morphology 0.0762427290243724 0.194616509438816 0.518800714837713 0.8125 26.3 26 3 abnormal intestinal absorption 0.0762427290243724 0.194616509438816 0.518800714837713 0.8125 26.3 26 3 abnormal extraembryonic endoderm formation 0.0762427290243724 0.194616509438816 0.518800714837713 0.8125 26.3 26 3 abnormal olfaction 0.0762427290243724 0.194616509438816 0.518800714837713 0.8125 26.3 26 3 abnormal pulmonary elastic fiber morphology 0.0762427290243724 0.194616509438816 0.518800714837713 0.8125 26.3 26 3 large intestinal inflammation 0.0762427290243724 0.194616509438816 0.518800714837713 0.8125 26.3 26 3 increased thymus weight 0.0762427290243724 0.194616509438816 0.518800714837713 0.8125 26.3 26 3 abnormal wound healing 0.0762427290243724 0.194616509438816 0.518800714837713 0.8125 26.3 26 3 abnormal amnion morphology 0.0762427290243724 0.194616509438816 0.518800714837713 0.8125 26.3 26 3 abnormal level of surface class II molecules 0.0762427290243724 0.194616509438816 0.518800714837713 0.8125 26.3 26 3 decreased circulating prolactin level 0.0762427290243724 0.194616509438816 0.518800714837713 0.8125 26.3 26 3 decreased fibroblast apoptosis 0.0762427290243724 0.194616509438816 0.518800714837713 0.8125 26.3 26 3 abnormal kidney physiology 0.00223704929292408 0.0106909896563855 0.518800714837713 0.8125 26.3 26 3 abnormal lymph node morphology 0.00223704929292408 0.0106909896563855 0.518800714837713 0.8125 26.3 26 3 abnormal coat appearance 0.000271192050031777 0.00175903578736388 0.518222341688507 0.811594202898551 26.3 26 3 increased white adipose tissue amount 0.00767452863415832 0.0297621058579481 0.517722127072977 0.810810810810811 26.3 26 3 increased inflammatory response 2.20128570699472e-05 0.000193487568768529 0.517540470186285 0.810526315789474 26.3 26 3 increased food intake 7.13075703269017e-05 0.000559550729300215 0.516900345918893 0.80952380952381 26.3 26 3 abnormal bile salt homeostasis 0.0451581192481411 0.130238633773624 0.516900345918893 0.80952380952381 26.3 26 3 increased susceptibility to injury 0.00190220792525627 0.00933282487983231 0.515730888122697 0.807692307692308 26.3 26 3 increased percent body fat/body weight 0.00190220792525627 0.00933282487983231 0.515730888122697 0.807692307692308 26.3 26 3 decreased Peyer's patch number 0.0272965223581927 0.0864418833430992 0.515730888122697 0.807692307692308 26.3 26 3 abnormal systemic arterial blood pressure 0.0103494978271008 0.0385106594538716 0.5143665206938 0.805555555555556 26.3 26 3 abnormal dendritic cell physiology 1.39495555547793e-05 0.000130204575769282 0.513206170824365 0.803738317757009 26.3 26 3 abnormal CD4-positive, alpha-beta T cell physiology 0.000414153783180334 0.00252811665192903 0.512617824411694 0.802816901408451 26.3 26 3 increased neutrophil cell number 7.39681019269939e-07 8.93182784191249e-06 0.510819165378671 0.8 26.3 26 3 abnormal circulating protein level 0.00339809801326801 0.0152714883613445 0.510819165378671 0.8 26.3 26 3 ruffled hair 0.0368533201783889 0.106969234473445 0.510819165378671 0.8 26.3 26 3 abnormal keratinocyte physiology 0.0368533201783889 0.106969234473445 0.510819165378671 0.8 26.3 26 3 decreased acute inflammation 0.0368533201783889 0.106969234473445 0.510819165378671 0.8 26.3 26 3 impaired conditioned place preference behavior 0.0368533201783889 0.106969234473445 0.510819165378671 0.8 26.3 26 3 abnormal thymocyte activation 0.0612836371676005 0.159292630568868 0.510819165378671 0.8 26.3 26 3 decreased salivation 0.104260275647146 0.237388957137094 0.510819165378671 0.8 26.3 26 3 hyperpigmentation 0.104260275647146 0.237388957137094 0.510819165378671 0.8 26.3 26 3 audiogenic seizures 0.104260275647146 0.237388957137094 0.510819165378671 0.8 26.3 26 3 abnormal respiratory system morphology 0.104260275647146 0.237388957137094 0.510819165378671 0.8 26.3 26 3 arthritis 0.104260275647146 0.237388957137094 0.510819165378671 0.8 26.3 26 3 increased alcohol consumption 0.104260275647146 0.237388957137094 0.510819165378671 0.8 26.3 26 3 dilated ureter 0.104260275647146 0.237388957137094 0.510819165378671 0.8 26.3 26 3 abnormal dendritic cell morphology 0.104260275647146 0.237388957137094 0.510819165378671 0.8 26.3 26 3 abnormal otic capsule morphology 0.184442395571869 0.352652159096866 0.510819165378671 0.8 26.3 26 3 small petrosal ganglion 0.184442395571869 0.352652159096866 0.510819165378671 0.8 26.3 26 3 abnormal optic nerve innervation 0.184442395571869 0.352652159096866 0.510819165378671 0.8 26.3 26 3 abnormal mammary gland physiology 0.184442395571869 0.352652159096866 0.510819165378671 0.8 26.3 26 3 decreased incidence of induced tumors 0.184442395571869 0.352652159096866 0.510819165378671 0.8 26.3 26 3 decreased circulating parathyroid hormone level 0.184442395571869 0.352652159096866 0.510819165378671 0.8 26.3 26 3 primary sex reversal 0.184442395571869 0.352652159096866 0.510819165378671 0.8 26.3 26 3 abnormal bone healing 0.184442395571869 0.352652159096866 0.510819165378671 0.8 26.3 26 3 rickets 0.184442395571869 0.352652159096866 0.510819165378671 0.8 26.3 26 3 abnormal submandibular gland morphology 0.184442395571869 0.352652159096866 0.510819165378671 0.8 26.3 26 3 abnormal placental transport 0.184442395571869 0.352652159096866 0.510819165378671 0.8 26.3 26 3 abnormal deltoid tuberosity morphology 0.184442395571869 0.352652159096866 0.510819165378671 0.8 26.3 26 3 decreased cochlear inner hair cell number 0.184442395571869 0.352652159096866 0.510819165378671 0.8 26.3 26 3 ascites 0.184442395571869 0.352652159096866 0.510819165378671 0.8 26.3 26 3 increased susceptibility to atherosclerosis 0.184442395571869 0.352652159096866 0.510819165378671 0.8 26.3 26 3 increased platelet aggregation 0.184442395571869 0.352652159096866 0.510819165378671 0.8 26.3 26 3 impaired behavioral response to morphine 0.184442395571869 0.352652159096866 0.510819165378671 0.8 26.3 26 3 hyperkeratosis 0.000728640044413992 0.00408218943801758 0.508968371301212 0.797101449275362 26.3 26 3 abnormal food intake 0.000728640044413992 0.00408218943801758 0.508968371301212 0.797101449275362 26.3 26 3 abnormal circadian rhythm 0.00718424711478064 0.0279013500359357 0.507916783757201 0.795454545454545 26.3 26 3 abnormal response to injury 0.0114949124216599 0.0420759680567735 0.50754468354932 0.794871794871795 26.3 26 3 abnormal retinal photoreceptor morphology 0.0185120663786452 0.0631309889228076 0.507063142103828 0.794117647058823 26.3 26 3 abnormal endoderm development 0.0185120663786452 0.0631309889228076 0.507063142103828 0.794117647058823 26.3 26 3 decreased regulatory T cell number 0.0185120663786452 0.0631309889228076 0.507063142103828 0.794117647058823 26.3 26 3 decreased cytotoxic T cell cytolysis 0.0185120663786452 0.0631309889228076 0.507063142103828 0.794117647058823 26.3 26 3 decreased granulocyte number 0.0300648391758953 0.0942486294266409 0.506415551884027 0.793103448275862 26.3 26 3 decreased retinal photoreceptor cell number 0.0300648391758953 0.0942486294266409 0.506415551884027 0.793103448275862 26.3 26 3 increased retinal apoptosis 0.0300648391758953 0.0942486294266409 0.506415551884027 0.793103448275862 26.3 26 3 obese 0.000515545995286924 0.00307534931241301 0.50584365402758 0.792207792207792 26.3 26 3 decreased ovulation rate 0.0493828203691294 0.138327321973865 0.505498132405976 0.791666666666667 26.3 26 3 hypopigmentation 0.0493828203691294 0.138327321973865 0.505498132405976 0.791666666666667 26.3 26 3 abnormal humoral immune response 6.20290656830872e-05 0.000491392677983055 0.504737984838449 0.79047619047619 26.3 26 3 abnormal nail morphology 0.0824241295854594 0.196345095518405 0.504097860571057 0.789473684210526 26.3 26 3 short vibrissae 0.0824241295854594 0.196345095518405 0.504097860571057 0.789473684210526 26.3 26 3 altered susceptibility to infection 0.0824241295854594 0.196345095518405 0.504097860571057 0.789473684210526 26.3 26 3 decreased tumor incidence 0.0824241295854594 0.196345095518405 0.504097860571057 0.789473684210526 26.3 26 3 increased susceptibility to ischemic brain injury 0.0824241295854594 0.196345095518405 0.504097860571057 0.789473684210526 26.3 26 3 decreased fertilization frequency 0.0824241295854594 0.196345095518405 0.504097860571057 0.789473684210526 26.3 26 3 shortened RR interval 0.0824241295854594 0.196345095518405 0.504097860571057 0.789473684210526 26.3 26 3 abnormal cytokine secretion 2.50886524039267e-06 2.72524117269727e-05 0.501697394568337 0.785714285714286 26.3 26 3 rib bifurcation 0.0399007116587594 0.115276446284743 0.501697394568337 0.785714285714286 26.3 26 3 decreased circulating progesterone level 0.0399007116587594 0.115276446284743 0.501697394568337 0.785714285714286 26.3 26 3 megacephaly 0.140989487977175 0.280120887654332 0.501697394568337 0.785714285714286 26.3 26 3 abnormal spleen periarteriolar lymphoid sheath morphology 0.140989487977175 0.280120887654332 0.501697394568337 0.785714285714286 26.3 26 3 absent otoliths 0.140989487977175 0.280120887654332 0.501697394568337 0.785714285714286 26.3 26 3 abnormal uterus development 0.140989487977175 0.280120887654332 0.501697394568337 0.785714285714286 26.3 26 3 abnormal imprinting 0.140989487977175 0.280120887654332 0.501697394568337 0.785714285714286 26.3 26 3 abnormal maternal decidual layer morphology 0.140989487977175 0.280120887654332 0.501697394568337 0.785714285714286 26.3 26 3 abnormal positive T cell selection 0.140989487977175 0.280120887654332 0.501697394568337 0.785714285714286 26.3 26 3 sternebra fusion 0.140989487977175 0.280120887654332 0.501697394568337 0.785714285714286 26.3 26 3 abnormal renal reabsorbtion 0.140989487977175 0.280120887654332 0.501697394568337 0.785714285714286 26.3 26 3 increased lung compliance 0.140989487977175 0.280120887654332 0.501697394568337 0.785714285714286 26.3 26 3 abnormal thrombosis 0.00649082812120911 0.0268427846242854 0.500803103312422 0.784313725490196 26.3 26 3 abnormal T cell activation 0.00115195636342975 0.00609031127318065 0.500464722837211 0.783783783783784 26.3 26 3 skin inflammation 0.0200462611515167 0.0653675065246093 0.500464722837211 0.783783783783784 26.3 26 3 abnormal lens development 0.0656382811333657 0.170522427487464 0.499714400913917 0.782608695652174 26.3 26 3 decreased susceptibility to parasitic infection 0.0323215514239972 0.0964601634491589 0.498846841190108 0.78125 26.3 26 3 abnormal serotonin level 0.0323215514239972 0.0964601634491589 0.498846841190108 0.78125 26.3 26 3 scaly skin 0.0163924392198274 0.0571896108826375 0.498360161345045 0.780487804878049 26.3 26 3 increased tumor growth/size 0.0163924392198274 0.0571896108826375 0.498360161345045 0.780487804878049 26.3 26 3 increased susceptibility to parasitic infection 0.000552494204212058 0.00328786921764951 0.496629744118152 0.777777777777778 26.3 26 3 increased susceptibility to bacterial infection induced morbidity/mortality 0.00193726535944571 0.00949546321501716 0.496629744118152 0.777777777777778 26.3 26 3 decreased osteoclast cell number 0.0134184487849074 0.0479919358051144 0.496629744118152 0.777777777777778 26.3 26 3 right pulmonary isomerism 0.109774046736925 0.249145019396078 0.496629744118152 0.777777777777778 26.3 26 3 abnormal white adipose tissue morphology 0.109774046736925 0.249145019396078 0.496629744118152 0.777777777777778 26.3 26 3 absent allantois 0.109774046736925 0.249145019396078 0.496629744118152 0.777777777777778 26.3 26 3 decreased activity of thyroid 0.109774046736925 0.249145019396078 0.496629744118152 0.777777777777778 26.3 26 3 decreased heart rate variability 0.109774046736925 0.249145019396078 0.496629744118152 0.777777777777778 26.3 26 3 abnormal sperm axoneme morphology 0.109774046736925 0.249145019396078 0.496629744118152 0.777777777777778 26.3 26 3 deformed nails 0.251638356210808 0.413578071406928 0.496629744118152 0.777777777777778 26.3 26 3 abnormal cholinergic neuron morphology 0.251638356210808 0.413578071406928 0.496629744118152 0.777777777777778 26.3 26 3 small geniculate ganglion 0.251638356210808 0.413578071406928 0.496629744118152 0.777777777777778 26.3 26 3 small nodose ganglion 0.251638356210808 0.413578071406928 0.496629744118152 0.777777777777778 26.3 26 3 abnormal vagina epithelium morphology 0.251638356210808 0.413578071406928 0.496629744118152 0.777777777777778 26.3 26 3 psoriasis 0.251638356210808 0.413578071406928 0.496629744118152 0.777777777777778 26.3 26 3 multifocal hepatic necrosis 0.251638356210808 0.413578071406928 0.496629744118152 0.777777777777778 26.3 26 3 abnormal lung volume 0.251638356210808 0.413578071406928 0.496629744118152 0.777777777777778 26.3 26 3 abnormal postural reflex 0.251638356210808 0.413578071406928 0.496629744118152 0.777777777777778 26.3 26 3 yellow coat color 0.251638356210808 0.413578071406928 0.496629744118152 0.777777777777778 26.3 26 3 abnormal lens capsule morphology 0.251638356210808 0.413578071406928 0.496629744118152 0.777777777777778 26.3 26 3 biliary cyst 0.251638356210808 0.413578071406928 0.496629744118152 0.777777777777778 26.3 26 3 pancreas cysts 0.251638356210808 0.413578071406928 0.496629744118152 0.777777777777778 26.3 26 3 decreased susceptibility to induced choroidal neovascularization 0.251638356210808 0.413578071406928 0.496629744118152 0.777777777777778 26.3 26 3 abnormal ovary physiology 0.251638356210808 0.413578071406928 0.496629744118152 0.777777777777778 26.3 26 3 abnormal bony labyrinth 0.251638356210808 0.413578071406928 0.496629744118152 0.777777777777778 26.3 26 3 abnormal proprioceptive neuron morphology 0.251638356210808 0.413578071406928 0.496629744118152 0.777777777777778 26.3 26 3 abnormal hair cell mechanoelectric transduction 0.251638356210808 0.413578071406928 0.496629744118152 0.777777777777778 26.3 26 3 abnormal gallbladder physiology 0.251638356210808 0.413578071406928 0.496629744118152 0.777777777777778 26.3 26 3 decreased susceptibility to atherosclerosis 0.251638356210808 0.413578071406928 0.496629744118152 0.777777777777778 26.3 26 3 abnormal retinal development 0.251638356210808 0.413578071406928 0.496629744118152 0.777777777777778 26.3 26 3 multiflagellated sperm 0.251638356210808 0.413578071406928 0.496629744118152 0.777777777777778 26.3 26 3 prolonged RR interval 0.251638356210808 0.413578071406928 0.496629744118152 0.777777777777778 26.3 26 3 decreased susceptibility to parasitic infection induced morbidity/mortality 0.251638356210808 0.413578071406928 0.496629744118152 0.777777777777778 26.3 26 3 increased core body temperature 0.251638356210808 0.413578071406928 0.496629744118152 0.777777777777778 26.3 26 3 decreased bone trabecular spacing 0.251638356210808 0.413578071406928 0.496629744118152 0.777777777777778 26.3 26 3 trigeminal neuroma 0.251638356210808 0.413578071406928 0.496629744118152 0.777777777777778 26.3 26 3 enhanced leukocyte tethering or rolling 0.251638356210808 0.413578071406928 0.496629744118152 0.777777777777778 26.3 26 3 decreased susceptibility to bacterial infection induced morbidity/mortality 0.042286010935065 0.122026046636861 0.49434112778581 0.774193548387097 26.3 26 3 abnormal intestine physiology 0.042286010935065 0.122026046636861 0.49434112778581 0.774193548387097 26.3 26 3 intestinal ulcer 0.0864860194874904 0.200217751023855 0.493404875649852 0.772727272727273 26.3 26 3 abnormal retinal layer morphology 0.0864860194874904 0.200217751023855 0.493404875649852 0.772727272727273 26.3 26 3 decreased circulating estradiol level 0.0864860194874904 0.200217751023855 0.493404875649852 0.772727272727273 26.3 26 3 rough coat 0.0864860194874904 0.200217751023855 0.493404875649852 0.772727272727273 26.3 26 3 impaired fertilization 0.00321336772842261 0.0144543439863494 0.492575623758004 0.771428571428571 26.3 26 3 abnormal NK cell physiology 0.00608298859787557 0.0256247826201786 0.491977474852408 0.770491803278688 26.3 26 3 decreased monocyte cell number 0.00500203930111086 0.0211608380297845 0.491172274402568 0.769230769230769 26.3 26 3 small seminal vesicle 0.0687093129123763 0.176564479204066 0.491172274402568 0.769230769230769 26.3 26 3 abnormal ocular fundus morphology 0.0687093129123763 0.176564479204066 0.491172274402568 0.769230769230769 26.3 26 3 uterus hypoplasia 0.188278431256885 0.358536836850151 0.491172274402568 0.769230769230769 26.3 26 3 abnormal vertebral arch development 0.188278431256885 0.358536836850151 0.491172274402568 0.769230769230769 26.3 26 3 hyperalgesia 0.188278431256885 0.358536836850151 0.491172274402568 0.769230769230769 26.3 26 3 increased renin activity 0.188278431256885 0.358536836850151 0.491172274402568 0.769230769230769 26.3 26 3 small lens 0.0276487464097295 0.0874459716391634 0.491172274402568 0.769230769230769 26.3 26 3 abnormal lens fiber morphology 0.0276487464097295 0.0874459716391634 0.491172274402568 0.769230769230769 26.3 26 3 abnormal response/metabolism to endogenous compounds 0.00180714758773364 0.00888395182705025 0.490573283824028 0.768292682926829 26.3 26 3 abnormal pain threshold 0.0549287673828671 0.143675403643409 0.489535033487893 0.766666666666667 26.3 26 3 abnormal immune system physiology 0.000169773918108072 0.00117202303270895 0.489191741038042 0.766129032258065 26.3 26 3 distended urinary bladder 0.144632380400853 0.286671749997707 0.488283025729612 0.764705882352941 26.3 26 3 abnormal tendon morphology 0.144632380400853 0.286671749997707 0.488283025729612 0.764705882352941 26.3 26 3 increased incidence of induced tumors 0.112885294509871 0.255506979156782 0.486494443217782 0.761904761904762 26.3 26 3 increased vasoconstriction 0.112885294509871 0.255506979156782 0.486494443217782 0.761904761904762 26.3 26 3 decreased cochlear outer hair cell number 0.112885294509871 0.255506979156782 0.486494443217782 0.761904761904762 26.3 26 3 increased bone ossification 0.112885294509871 0.255506979156782 0.486494443217782 0.761904761904762 26.3 26 3 abnormal feces composition 0.0890595709731407 0.205888181036884 0.485278207109737 0.76 26.3 26 3 abnormal CD8-positive, alpha-beta T cell physiology 0.0708134537477606 0.181877610942235 0.484397484410808 0.758620689655172 26.3 26 3 abnormal spleen germinal center morphology 0.0905615590140166 0.20916608918047 0.478892967542504 0.75 26.3 26 3 abnormal pituitary gland morphology 0.188312915515466 0.358536836850151 0.478892967542504 0.75 26.3 26 3 mixed cellular infiltration to dermis 0.188312915515466 0.358536836850151 0.478892967542504 0.75 26.3 26 3 increased pancreatic beta cell number 0.188312915515466 0.358536836850151 0.478892967542504 0.75 26.3 26 3 abnormal molar crown morphology 0.188312915515466 0.358536836850151 0.478892967542504 0.75 26.3 26 3 small epididymis 0.188312915515466 0.358536836850151 0.478892967542504 0.75 26.3 26 3 absent pre-B cells 0.337275492571204 0.518326332883637 0.478892967542504 0.75 26.3 26 3 abnormal cecum morphology 0.337275492571204 0.518326332883637 0.478892967542504 0.75 26.3 26 3 abnormal drinking behavior 0.337275492571204 0.518326332883637 0.478892967542504 0.75 26.3 26 3 vascular smooth muscle hypertrophy 0.337275492571204 0.518326332883637 0.478892967542504 0.75 26.3 26 3 decreased susceptibility to age related obesity 0.337275492571204 0.518326332883637 0.478892967542504 0.75 26.3 26 3 liver cysts 0.337275492571204 0.518326332883637 0.478892967542504 0.75 26.3 26 3 decreased circulating renin level 0.337275492571204 0.518326332883637 0.478892967542504 0.75 26.3 26 3 hair follicle degeneration 0.337275492571204 0.518326332883637 0.478892967542504 0.75 26.3 26 3 abnormal miscarriage rate 0.337275492571204 0.518326332883637 0.478892967542504 0.75 26.3 26 3 abnormal vestibular labyrinth morphology 0.337275492571204 0.518326332883637 0.478892967542504 0.75 26.3 26 3 abnormal optic choroid morphology 0.337275492571204 0.518326332883637 0.478892967542504 0.75 26.3 26 3 abnormal canal of Schlemm morphology 0.337275492571204 0.518326332883637 0.478892967542504 0.75 26.3 26 3 decreased susceptibility to autoimmune disorder 0.337275492571204 0.518326332883637 0.478892967542504 0.75 26.3 26 3 abnormal ilium morphology 0.337275492571204 0.518326332883637 0.478892967542504 0.75 26.3 26 3 abnormal mast cell differentiation 0.337275492571204 0.518326332883637 0.478892967542504 0.75 26.3 26 3 enlarged inguinal lymph nodes 0.337275492571204 0.518326332883637 0.478892967542504 0.75 26.3 26 3 urinary bladder inflammation 0.337275492571204 0.518326332883637 0.478892967542504 0.75 26.3 26 3 abnormal sensory neuron physiology 0.337275492571204 0.518326332883637 0.478892967542504 0.75 26.3 26 3 pulmonary artery hypoplasia 0.337275492571204 0.518326332883637 0.478892967542504 0.75 26.3 26 3 myocardial trabeculae hypoplasia 0.337275492571204 0.518326332883637 0.478892967542504 0.75 26.3 26 3 abnormal bronchiole epithelium morphology 0.337275492571204 0.518326332883637 0.478892967542504 0.75 26.3 26 3 abnormal pulmonary acinus morphology 0.337275492571204 0.518326332883637 0.478892967542504 0.75 26.3 26 3 decreased surfactant secretion 0.337275492571204 0.518326332883637 0.478892967542504 0.75 26.3 26 3 lethality during fetal growth through weaning, incomplete penetrance 0.337275492571204 0.518326332883637 0.478892967542504 0.75 26.3 26 3 increased circulating ferritin level 0.337275492571204 0.518326332883637 0.478892967542504 0.75 26.3 26 3 increased circulating lactate level 0.337275492571204 0.518326332883637 0.478892967542504 0.75 26.3 26 3 retropleural edema 0.337275492571204 0.518326332883637 0.478892967542504 0.75 26.3 26 3 decreased susceptibility to injury 0.0109535749668765 0.0406065838004552 0.478892967542504 0.75 26.3 26 3 decreased IgA level 0.0247206083566256 0.0783344118307084 0.478892967542504 0.75 26.3 26 3 increased circulating total protein level 0.114404663426075 0.2582859878887 0.478892967542504 0.75 26.3 26 3 abnormal hair texture 0.145845606839036 0.288387080295789 0.478892967542504 0.75 26.3 26 3 decreased skin tensile strength 0.145845606839036 0.288387080295789 0.478892967542504 0.75 26.3 26 3 increased urine calcium level 0.145845606839036 0.288387080295789 0.478892967542504 0.75 26.3 26 3 decreased digestive secretion 0.2478846295418 0.413578071406928 0.478892967542504 0.75 26.3 26 3 abnormal pilomotor reflex 0.2478846295418 0.413578071406928 0.478892967542504 0.75 26.3 26 3 increased litter size 0.2478846295418 0.413578071406928 0.478892967542504 0.75 26.3 26 3 absent tail 0.2478846295418 0.413578071406928 0.478892967542504 0.75 26.3 26 3 decreased circulating ketone body level 0.2478846295418 0.413578071406928 0.478892967542504 0.75 26.3 26 3 impaired sperm capacitation 0.2478846295418 0.413578071406928 0.478892967542504 0.75 26.3 26 3 increased placenta weight 0.2478846295418 0.413578071406928 0.478892967542504 0.75 26.3 26 3 hydrometra 0.2478846295418 0.413578071406928 0.478892967542504 0.75 26.3 26 3 impaired behavioral response to cocaine 0.2478846295418 0.413578071406928 0.478892967542504 0.75 26.3 26 3 increased type II pneumocyte number 0.2478846295418 0.413578071406928 0.478892967542504 0.75 26.3 26 3 abnormal epidermis stratum granulosum morphology 0.0578363756457537 0.15048952345064 0.478892967542504 0.75 26.3 26 3 abnormal intestinal mucosa morphology 0.0472598325550166 0.135280590886771 0.475180618956903 0.744186046511628 26.3 26 3 autoimmune response 0.0912766921702988 0.210719973803822 0.473743580794735 0.741935483870968 26.3 26 3 blistering 0.145554611490844 0.288155269465558 0.471952489752033 0.739130434782609 26.3 26 3 increased susceptibility to age related obesity 0.145554611490844 0.288155269465558 0.471952489752033 0.739130434782609 26.3 26 3 abnormal hepatocyte physiology 0.145554611490844 0.288155269465558 0.471952489752033 0.739130434782609 26.3 26 3 abnormal vibrissa morphology 0.0590574492046082 0.153586413901164 0.471291491867226 0.738095238095238 26.3 26 3 osteoarthritis 0.186353814761028 0.356033113838753 0.470491336532986 0.736842105263158 26.3 26 3 thin interventricular septum 0.186353814761028 0.356033113838753 0.470491336532986 0.736842105263158 26.3 26 3 abnormal skin physiology 0.0914051829754094 0.210918731587506 0.469502909355396 0.735294117647059 26.3 26 3 abnormal epidermis stratum spinosum morphology 0.241994821884757 0.410895644667804 0.468250901597115 0.733333333333333 26.3 26 3 increased airway responsiveness 0.241994821884757 0.410895644667804 0.468250901597115 0.733333333333333 26.3 26 3 altered righting response 0.241994821884757 0.410895644667804 0.468250901597115 0.733333333333333 26.3 26 3 abnormal Muller cell morphology 0.241994821884757 0.410895644667804 0.468250901597115 0.733333333333333 26.3 26 3 abnormal leukocyte cell number 0.144295985709501 0.286233065751502 0.46661366068244 0.730769230769231 26.3 26 3 decreased susceptibility to viral infection induced morbidity/mortality 0.183283361236218 0.352652159096866 0.464381059435155 0.727272727272727 26.3 26 3 abnormal sperm midpiece morphology 0.183283361236218 0.352652159096866 0.464381059435155 0.727272727272727 26.3 26 3 increased mast cell number 0.321136661199055 0.518326332883637 0.464381059435155 0.727272727272727 26.3 26 3 abnormal primary sex determination 0.321136661199055 0.518326332883637 0.464381059435155 0.727272727272727 26.3 26 3 abnormal bronchiole morphology 0.321136661199055 0.518326332883637 0.464381059435155 0.727272727272727 26.3 26 3 enhanced behavioral response to addictive substance 0.321136661199055 0.518326332883637 0.464381059435155 0.727272727272727 26.3 26 3 abnormal aorta smooth muscle morphology 0.321136661199055 0.518326332883637 0.464381059435155 0.727272727272727 26.3 26 3 decreased palatine bone horizontal plate size 0.321136661199055 0.518326332883637 0.464381059435155 0.727272727272727 26.3 26 3 abnormal extraembryonic ectoderm morphology 0.321136661199055 0.518326332883637 0.464381059435155 0.727272727272727 26.3 26 3 decreased core body temperature 0.321136661199055 0.518326332883637 0.464381059435155 0.727272727272727 26.3 26 3 increased pancreatic beta cell proliferation 0.321136661199055 0.518326332883637 0.464381059435155 0.727272727272727 26.3 26 3 impaired ovarian folliculogenesis 0.0904412966886921 0.208985346505454 0.46292986862442 0.725 26.3 26 3 stomach inflammation 0.142400335337938 0.282585428123751 0.46237941693759 0.724137931034483 26.3 26 3 increased susceptibility to induced arthritis 0.142400335337938 0.282585428123751 0.46237941693759 0.724137931034483 26.3 26 3 enlarged epididymis 0.142400335337938 0.282585428123751 0.46237941693759 0.724137931034483 26.3 26 3 abnormal retinal rod cell morphology 0.235264047927068 0.400013205207505 0.461156190966856 0.722222222222222 26.3 26 3 thick dermal layer 0.235264047927068 0.400013205207505 0.461156190966856 0.722222222222222 26.3 26 3 abnormal Peyer's patch follicle morphology 0.235264047927068 0.400013205207505 0.461156190966856 0.722222222222222 26.3 26 3 increased susceptibility to autoimmune disorder 0.235264047927068 0.400013205207505 0.461156190966856 0.722222222222222 26.3 26 3 impaired leukocyte tethering or rolling 0.235264047927068 0.400013205207505 0.461156190966856 0.722222222222222 26.3 26 3 acanthosis 0.110773811693556 0.251184919405398 0.458427456109063 0.717948717948718 26.3 26 3 abnormal leukocyte adhesion 0.110773811693556 0.251184919405398 0.458427456109063 0.717948717948718 26.3 26 3 abnormal immune system morphology 0.0884317813059521 0.204531897720647 0.458071534171091 0.717391304347826 26.3 26 3 abnormal epidermis stratum corneum morphology 0.0871793398843853 0.20172893763945 0.45608854051667 0.714285714285714 26.3 26 3 increased circulating luteinizing hormone level 0.175512591806303 0.338046900594796 0.45608854051667 0.714285714285714 26.3 26 3 abnormal olfactory system physiology 0.306500789456159 0.502418921760919 0.45608854051667 0.714285714285714 26.3 26 3 abnormal decidualization 0.306500789456159 0.502418921760919 0.45608854051667 0.714285714285714 26.3 26 3 abnormal respiratory motile cilium physiology 0.306500789456159 0.502418921760919 0.45608854051667 0.714285714285714 26.3 26 3 mottled coat 0.442514964893509 0.608320516812713 0.45608854051667 0.714285714285714 26.3 26 3 abnormal foot pad morphology 0.442514964893509 0.608320516812713 0.45608854051667 0.714285714285714 26.3 26 3 small L4 dorsal root ganglion 0.442514964893509 0.608320516812713 0.45608854051667 0.714285714285714 26.3 26 3 abnormal liquid preference 0.442514964893509 0.608320516812713 0.45608854051667 0.714285714285714 26.3 26 3 absent amniotic folds 0.442514964893509 0.608320516812713 0.45608854051667 0.714285714285714 26.3 26 3 decreased activated T cell number 0.442514964893509 0.608320516812713 0.45608854051667 0.714285714285714 26.3 26 3 increased colonic adenoma incidence 0.442514964893509 0.608320516812713 0.45608854051667 0.714285714285714 26.3 26 3 abnormal thyroid gland development 0.442514964893509 0.608320516812713 0.45608854051667 0.714285714285714 26.3 26 3 abnormal prostate gland physiology 0.442514964893509 0.608320516812713 0.45608854051667 0.714285714285714 26.3 26 3 absent vestibular saccule 0.442514964893509 0.608320516812713 0.45608854051667 0.714285714285714 26.3 26 3 absent vestibular hair cells 0.442514964893509 0.608320516812713 0.45608854051667 0.714285714285714 26.3 26 3 increased prostate gland weight 0.442514964893509 0.608320516812713 0.45608854051667 0.714285714285714 26.3 26 3 abnormal gallbladder morphology 0.442514964893509 0.608320516812713 0.45608854051667 0.714285714285714 26.3 26 3 decreased adrenocorticotropin level 0.442514964893509 0.608320516812713 0.45608854051667 0.714285714285714 26.3 26 3 atherosclerotic lesions 0.442514964893509 0.608320516812713 0.45608854051667 0.714285714285714 26.3 26 3 increased chronic myelocytic leukemia incidence 0.442514964893509 0.608320516812713 0.45608854051667 0.714285714285714 26.3 26 3 abnormal renal/urinary system physiology 0.442514964893509 0.608320516812713 0.45608854051667 0.714285714285714 26.3 26 3 postaxial polydactyly 0.442514964893509 0.608320516812713 0.45608854051667 0.714285714285714 26.3 26 3 abnormal sperm annulus morphology 0.442514964893509 0.608320516812713 0.45608854051667 0.714285714285714 26.3 26 3 decreased T-helper 17 cell number 0.442514964893509 0.608320516812713 0.45608854051667 0.714285714285714 26.3 26 3 dilated pulmonary alveolar ducts 0.442514964893509 0.608320516812713 0.45608854051667 0.714285714285714 26.3 26 3 absent heart tube 0.442514964893509 0.608320516812713 0.45608854051667 0.714285714285714 26.3 26 3 abnormal Mullerian duct topology 0.442514964893509 0.608320516812713 0.45608854051667 0.714285714285714 26.3 26 3 abnormal tectorial membrane striated-sheet matrix morphology 0.442514964893509 0.608320516812713 0.45608854051667 0.714285714285714 26.3 26 3 increased abdominal adipose tissue amount 0.442514964893509 0.608320516812713 0.45608854051667 0.714285714285714 26.3 26 3 hypoalgesia 0.228246387661949 0.388878691307602 0.45608854051667 0.714285714285714 26.3 26 3 abnormal body temperature homeostasis 0.171255483449016 0.33232223134022 0.45314603380366 0.709677419354839 26.3 26 3 abnormal hair shaft morphology 0.105070741560063 0.239124857850554 0.452287802679031 0.708333333333333 26.3 26 3 small lymph nodes 0.221204485362424 0.387414685053543 0.452287802679031 0.708333333333333 26.3 26 3 increased susceptibility to viral infection induced morbidity/mortality 0.16691210413285 0.329911687747687 0.45072279298118 0.705882352941177 26.3 26 3 abnormal melanosome morphology 0.293146199790538 0.481003411595622 0.45072279298118 0.705882352941177 26.3 26 3 waved hair 0.28087296657901 0.461017158934534 0.446966769706337 0.7 26.3 26 3 abnormal circulating cytokine level 0.28087296657901 0.461017158934534 0.446966769706337 0.7 26.3 26 3 abnormal epidermis suprabasal layer morphology 0.408428931034999 0.566313804877124 0.446966769706337 0.7 26.3 26 3 abnormal glial cell physiology 0.408428931034999 0.566313804877124 0.446966769706337 0.7 26.3 26 3 decreased prolactin level 0.408428931034999 0.566313804877124 0.446966769706337 0.7 26.3 26 3 abnormal sperm principal piece morphology 0.408428931034999 0.566313804877124 0.446966769706337 0.7 26.3 26 3 abnormal vibrissa follicle morphology 0.408428931034999 0.566313804877124 0.446966769706337 0.7 26.3 26 3 increased kidney iron level 0.408428931034999 0.566313804877124 0.446966769706337 0.7 26.3 26 3 decreased macrophage cytokine production 0.408428931034999 0.566313804877124 0.446966769706337 0.7 26.3 26 3 decreased epididymis weight 0.26952050351136 0.442675637163755 0.444190578590148 0.695652173913043 26.3 26 3 increased susceptibility to fungal infection 0.26952050351136 0.442675637163755 0.444190578590148 0.695652173913043 26.3 26 3 abnormal mast cell morphology 0.381998575682861 0.530849975983864 0.442055046962311 0.692307692307692 26.3 26 3 increased circulating adrenocorticotropin level 0.381998575682861 0.530849975983864 0.442055046962311 0.692307692307692 26.3 26 3 decreased follicle stimulating hormone level 0.381998575682861 0.530849975983864 0.442055046962311 0.692307692307692 26.3 26 3 decreased luteinizing hormone level 0.381998575682861 0.530849975983864 0.442055046962311 0.692307692307692 26.3 26 3 abnormal hair follicle inner root sheath morphology 0.381998575682861 0.530849975983864 0.442055046962311 0.692307692307692 26.3 26 3 abnormal intestinal lipid absorption 0.360095015897195 0.518326332883637 0.438985220247295 0.6875 26.3 26 3 abnormal fertilization 0.360095015897195 0.518326332883637 0.438985220247295 0.6875 26.3 26 3 abnormal urinary bladder physiology 0.360095015897195 0.518326332883637 0.438985220247295 0.6875 26.3 26 3 decreased liver glycogen level 0.34123621978682 0.518326332883637 0.436884812494916 0.684210526315789 26.3 26 3 abnormal stomach mucosa morphology 0.309661280359343 0.507432434053931 0.43419629057187 0.68 26.3 26 3 curly vibrissae 0.366152539809232 0.518326332883637 0.425682637815559 0.666666666666667 26.3 26 3 abnormal cellular extravasation 0.366152539809232 0.518326332883637 0.425682637815559 0.666666666666667 26.3 26 3 abnormal esophagus morphology 0.467640724513564 0.64215087067485 0.425682637815559 0.666666666666667 26.3 26 3 increased urine phosphate level 0.467640724513564 0.64215087067485 0.425682637815559 0.666666666666667 26.3 26 3 increased fear-related response 0.467640724513564 0.64215087067485 0.425682637815559 0.666666666666667 26.3 26 3 abnormal anogenital distance 0.467640724513564 0.64215087067485 0.425682637815559 0.666666666666667 26.3 26 3 impaired natural killer cell mediated cytotoxicity 0.232014215364949 0.395162862526744 0.425682637815559 0.666666666666667 26.3 26 3 dry skin 0.38612612441313 0.536436042713019 0.425682637815559 0.666666666666667 26.3 26 3 abnormal iron level 0.408910503517478 0.566665669916282 0.425682637815559 0.666666666666667 26.3 26 3 abnormal macrophage chemotaxis 0.408910503517478 0.566665669916282 0.425682637815559 0.666666666666667 26.3 26 3 abnormal vagina orifice morphology 0.508549765291997 0.665119235019636 0.425682637815559 0.666666666666667 26.3 26 3 abnormal lens vesicle development 0.508549765291997 0.665119235019636 0.425682637815559 0.666666666666667 26.3 26 3 abnormal taste sensitivity 0.508549765291997 0.665119235019636 0.425682637815559 0.666666666666667 26.3 26 3 long gestation period 0.508549765291997 0.665119235019636 0.425682637815559 0.666666666666667 26.3 26 3 abnormal gut-associated lymphoid tissue morphology 0.508549765291997 0.665119235019636 0.425682637815559 0.666666666666667 26.3 26 3 brittle hair 0.508549765291997 0.665119235019636 0.425682637815559 0.666666666666667 26.3 26 3 increased circulating progesterone level 0.508549765291997 0.665119235019636 0.425682637815559 0.666666666666667 26.3 26 3 increased stomach mucosa thickness 0.508549765291997 0.665119235019636 0.425682637815559 0.666666666666667 26.3 26 3 abnormal incisor color 0.508549765291997 0.665119235019636 0.425682637815559 0.666666666666667 26.3 26 3 adipose tissue inflammation 0.508549765291997 0.665119235019636 0.425682637815559 0.666666666666667 26.3 26 3 joint inflammation 0.435512724598963 0.602859155503572 0.425682637815559 0.666666666666667 26.3 26 3 greasy coat 0.435512724598963 0.602859155503572 0.425682637815559 0.666666666666667 26.3 26 3 decreased trabecular bone mass 0.435512724598963 0.602859155503572 0.425682637815559 0.666666666666667 26.3 26 3 abnormal regulatory T cell physiology 0.427861779674256 0.592763117203961 0.416428667428264 0.652173913043478 26.3 26 3 enlarged sebaceous gland 0.482834512092734 0.658714980571043 0.413162560232748 0.647058823529412 26.3 26 3 increased B-1 B cell number 0.517894590890924 0.665119235019636 0.410479686465003 0.642857142857143 26.3 26 3 abnormal iris pigmentation 0.517894590890924 0.665119235019636 0.410479686465003 0.642857142857143 26.3 26 3 abnormal hair medulla 0.561190403247901 0.665119235019636 0.406333427005761 0.636363636363636 26.3 26 3 salivary gland inflammation 0.477127408073134 0.654816235907267 0.404398505924781 0.633333333333333 26.3 26 3 abnormal estrous cycle 0.477127408073134 0.654816235907267 0.404398505924781 0.633333333333333 26.3 26 3 flaky skin 0.524923561341462 0.665119235019636 0.403278288456845 0.631578947368421 26.3 26 3 abnormal pancreatic alpha cell morphology 0.561208905768575 0.665119235019636 0.399077472952087 0.625 26.3 26 3 abnormal Langerhans cell physiology 0.561208905768575 0.665119235019636 0.399077472952087 0.625 26.3 26 3 abnormal parturition 0.617914085430685 0.671645745033354 0.399077472952087 0.625 26.3 26 3 joint swelling 0.617914085430685 0.671645745033354 0.399077472952087 0.625 26.3 26 3 urinary incontinence 0.617914085430685 0.671645745033354 0.399077472952087 0.625 26.3 26 3 abnormal platelet shape 0.617914085430685 0.671645745033354 0.399077472952087 0.625 26.3 26 3 abnormal thermosensation 0.617914085430685 0.671645745033354 0.399077472952087 0.625 26.3 26 3 increased circulating prolactin level 0.617914085430685 0.671645745033354 0.399077472952087 0.625 26.3 26 3 abnormal corneocyte envelope morphology 0.617914085430685 0.671645745033354 0.399077472952087 0.625 26.3 26 3 hypergranulosis 0.617914085430685 0.671645745033354 0.399077472952087 0.625 26.3 26 3 skin fibrosis 0.617914085430685 0.671645745033354 0.399077472952087 0.625 26.3 26 3 decreased serotonin level 0.617914085430685 0.671645745033354 0.399077472952087 0.625 26.3 26 3 decreased susceptibility to weight loss 0.617914085430685 0.671645745033354 0.399077472952087 0.625 26.3 26 3 abnormal stomach position or orientation 0.617914085430685 0.671645745033354 0.399077472952087 0.625 26.3 26 3 decreased alcohol consumption 0.604668162642691 0.665119235019636 0.392937819522054 0.615384615384615 26.3 26 3 nuclear cataracts 0.632299796880239 0.687132260698818 0.383114374034003 0.6 26.3 26 3 abnormal airway responsiveness 0.658731016677494 0.70682164819602 0.383114374034003 0.6 26.3 26 3 increased defecation amount 0.658731016677494 0.70682164819602 0.383114374034003 0.6 26.3 26 3 decreased macrophage apoptosis 0.658731016677494 0.70682164819602 0.383114374034003 0.6 26.3 26 3 decreased airway responsiveness 0.661876173472386 0.70682164819602 0.377309610791064 0.590909090909091 26.3 26 3 abnormal hair cuticle 0.720366258311713 0.763978285035339 0.364870832413336 0.571428571428571 26.3 26 3 abnormal epididymis epithelium morphology 0.744656870477815 0.788562777911267 0.359169725656878 0.5625 26.3 26 3 increased circulating estradiol level 0.744656870477815 0.788562777911267 0.359169725656878 0.5625 26.3 26 3 abnormal dendritic cell chemotaxis 0.775779752793005 0.821345875749138 0.348285794576366 0.545454545454545 26.3 26 3 total cataracts 0.794233709448133 0.840525995427454 0.343820592081798 0.538461538461538 26.3 26 3 abnormal gut flora balance 0.794233709448133 0.840525995427454 0.343820592081798 0.538461538461538 26.3 26 3 increased acute inflammation 0.849949959217723 0.872935806587154 0.334464929712225 0.523809523809524 26.3 26 3 increased natural killer cell mediated cytotoxicity 0.8505079545306 0.873148385016454 0.319261978361669 0.5 26.3 26 3 intestinal edema 0.8505079545306 0.873148385016454 0.319261978361669 0.5 26.3 26 3 embryo cyst 0.000260529001107534 0.00338415608488246 1.80502728625765 1 27.1 27 1 increased circulating fructosamine level 3.30817801397303e-05 0.000573455944930866 1.80502728625765 1 27.1 27 1 abnormal NMDA-mediated synaptic currents 9.28397661099674e-05 0.00137873981014056 1.80502728625765 1 27.1 27 1 abnormal Purkinje cell innervation 0.000731063301941278 0.00788945754264177 1.80502728625765 1 27.1 27 1 abnormal aortic valve cusp morphology 0.000731063301941278 0.00788945754264177 1.80502728625765 1 27.1 27 1 ductus venosus stenosis 0.000731063301941278 0.00788945754264177 1.80502728625765 1 27.1 27 1 small hair follicles 0.00575550493301973 0.0421082897673135 1.80502728625765 1 27.1 27 1 abnormal pineal gland morphology 0.00575550493301973 0.0421082897673135 1.80502728625765 1 27.1 27 1 skin hyperplasia 0.00575550493301973 0.0421082897673135 1.80502728625765 1 27.1 27 1 decreased lysosomal enzyme secretion 0.00575550493301973 0.0421082897673135 1.80502728625765 1 27.1 27 1 increased heart right ventricle weight 0.00575550493301973 0.0421082897673135 1.80502728625765 1 27.1 27 1 decreased small intestinal villus height 0.00575550493301973 0.0421082897673135 1.80502728625765 1 27.1 27 1 decreased platelet alpha-granule number 0.00575550493301973 0.0421082897673135 1.80502728625765 1 27.1 27 1 delayed brain development 0.00205130750126111 0.0178726003831419 1.80502728625765 1 27.1 27 1 chromatolysis 0.00205130750126111 0.0178726003831419 1.80502728625765 1 27.1 27 1 loss of hippocampal neurons 0.00205130750126111 0.0178726003831419 1.80502728625765 1 27.1 27 1 decreased prostate gland weight 0.00205130750126111 0.0178726003831419 1.80502728625765 1 27.1 27 1 abnormal voluntary movement 1.40182096297576e-05 0.000268233049646323 1.67609676581067 0.928571428571429 27.1 27 1 lysosomal protein accumulation 1.40182096297576e-05 0.000268233049646323 1.67609676581067 0.928571428571429 27.1 27 1 abnormal vitelline vein topology 1.40182096297576e-05 0.000268233049646323 1.67609676581067 0.928571428571429 27.1 27 1 axonal dystrophy 3.66420363528497e-05 0.000630775539292136 1.6661790334686 0.923076923076923 27.1 27 1 aorta dilation 0.000246024889313026 0.0032380259902971 1.64093389659786 0.909090909090909 27.1 27 1 increased cranium width 0.000630661639842101 0.00692614052585971 1.62452455763188 0.9 27.1 27 1 ketoaciduria 0.000630661639842101 0.00692614052585971 1.62452455763188 0.9 27.1 27 1 acrania 0.000630661639842101 0.00692614052585971 1.62452455763188 0.9 27.1 27 1 bifid ureter 0.000630661639842101 0.00692614052585971 1.62452455763188 0.9 27.1 27 1 abnormal hippocampus neuron morphology 0.000630661639842101 0.00692614052585971 1.62452455763188 0.9 27.1 27 1 thin ventricle myocardium compact layer 0.000630661639842101 0.00692614052585971 1.62452455763188 0.9 27.1 27 1 increased pheochromocytoma incidence 0.00160204288108807 0.0150097237917385 1.60446869889569 0.888888888888889 27.1 27 1 decreased muscle weight 0.00160204288108807 0.0150097237917385 1.60446869889569 0.888888888888889 27.1 27 1 abnormal inguinal fat pad morphology 0.00160204288108807 0.0150097237917385 1.60446869889569 0.888888888888889 27.1 27 1 abnormal hippocampus granule cell morphology 0.00160204288108807 0.0150097237917385 1.60446869889569 0.888888888888889 27.1 27 1 abnormal ductus venosus valve topology 0.00160204288108807 0.0150097237917385 1.60446869889569 0.888888888888889 27.1 27 1 cerebellum atrophy 0.00160204288108807 0.0150097237917385 1.60446869889569 0.888888888888889 27.1 27 1 decreased platelet dense granule number 0.00160204288108807 0.0150097237917385 1.60446869889569 0.888888888888889 27.1 27 1 absence seizures 1.14679250106411e-05 0.000230052124709434 1.59267113493322 0.882352941176471 27.1 27 1 colon polyps 0.00402480340777749 0.0309959705165527 1.57939887547544 0.875 27.1 27 1 increased cardiac output 0.00402480340777749 0.0309959705165527 1.57939887547544 0.875 27.1 27 1 craniofacial phenotype 0.00402480340777749 0.0309959705165527 1.57939887547544 0.875 27.1 27 1 abnormal olfactory bulb glomerular layer morphology 0.00402480340777749 0.0309959705165527 1.57939887547544 0.875 27.1 27 1 decreased hippocampus pyramidal cell number 0.00402480340777749 0.0309959705165527 1.57939887547544 0.875 27.1 27 1 increased caudal vertebrae number 0.00402480340777749 0.0309959705165527 1.57939887547544 0.875 27.1 27 1 pleural effusion 0.00402480340777749 0.0309959705165527 1.57939887547544 0.875 27.1 27 1 sinoatrial block 0.00402480340777749 0.0309959705165527 1.57939887547544 0.875 27.1 27 1 lung situs inversus 0.00402480340777749 0.0309959705165527 1.57939887547544 0.875 27.1 27 1 impaired neuron differentiation 0.00402480340777749 0.0309959705165527 1.57939887547544 0.875 27.1 27 1 absent hypoglossal canal 0.00402480340777749 0.0309959705165527 1.57939887547544 0.875 27.1 27 1 retropleural edema 0.00402480340777749 0.0309959705165527 1.57939887547544 0.875 27.1 27 1 decreased basal metabolism 0.00402480340777749 0.0309959705165527 1.57939887547544 0.875 27.1 27 1 amyloid beta deposits 0.000172384996691402 0.00234321136213039 1.5471662453637 0.857142857142857 27.1 27 1 multiple persisting craniopharyngeal ducts 0.000172384996691402 0.00234321136213039 1.5471662453637 0.857142857142857 27.1 27 1 broad head 0.00997277269718008 0.0637719076715565 1.5471662453637 0.857142857142857 27.1 27 1 polyphalangy 0.00997277269718008 0.0637719076715565 1.5471662453637 0.857142857142857 27.1 27 1 excessive tearing 0.00997277269718008 0.0637719076715565 1.5471662453637 0.857142857142857 27.1 27 1 abnormal gastrulation movements 0.00997277269718008 0.0637719076715565 1.5471662453637 0.857142857142857 27.1 27 1 abnormal brain ventricular system morphology 0.00997277269718008 0.0637719076715565 1.5471662453637 0.857142857142857 27.1 27 1 abnormal inhibitory postsynaptic potential 0.00997277269718008 0.0637719076715565 1.5471662453637 0.857142857142857 27.1 27 1 aorta coarctation 0.00997277269718008 0.0637719076715565 1.5471662453637 0.857142857142857 27.1 27 1 increased cell nucleus count 0.00997277269718008 0.0637719076715565 1.5471662453637 0.857142857142857 27.1 27 1 abnormal optic tract morphology 0.00997277269718008 0.0637719076715565 1.5471662453637 0.857142857142857 27.1 27 1 abnormal organ of Corti supporting cell morphology 0.00997277269718008 0.0637719076715565 1.5471662453637 0.857142857142857 27.1 27 1 decreased tidal volume 0.00997277269718008 0.0637719076715565 1.5471662453637 0.857142857142857 27.1 27 1 abnormal spinal cord central canal morphology 0.00997277269718008 0.0637719076715565 1.5471662453637 0.857142857142857 27.1 27 1 heart hemorrhage 0.00997277269718008 0.0637719076715565 1.5471662453637 0.857142857142857 27.1 27 1 increased oligodendrocyte number 0.00997277269718008 0.0637719076715565 1.5471662453637 0.857142857142857 27.1 27 1 decreased brain cholesterol level 0.00997277269718008 0.0637719076715565 1.5471662453637 0.857142857142857 27.1 27 1 abnormal retina inner limiting membrane morphology 0.00997277269718008 0.0637719076715565 1.5471662453637 0.857142857142857 27.1 27 1 abnormal conotruncal ridge morphology 0.00997277269718008 0.0637719076715565 1.5471662453637 0.857142857142857 27.1 27 1 abnormal outer hair cell kinocilium morphology 0.00997277269718008 0.0637719076715565 1.5471662453637 0.857142857142857 27.1 27 1 embryonic lethality at implantation, incomplete penetrance 0.00997277269718008 0.0637719076715565 1.5471662453637 0.857142857142857 27.1 27 1 decreased CD8-positive, naive alpha-beta T cell number 0.00997277269718008 0.0637719076715565 1.5471662453637 0.857142857142857 27.1 27 1 increased skin tumor incidence 8.04632835251645e-06 0.000164734500221273 1.534273193319 0.85 27.1 27 1 absent hypoglossal nerve 0.000417605334212707 0.00505495507958203 1.52733078067955 0.846153846153846 27.1 27 1 abnormal synaptic transmission 1.09706769752268e-07 3.54409856829568e-06 1.50418940521471 0.833333333333333 27.1 27 1 abnormal respiratory function 0.000999890463452481 0.0100296137821439 1.50418940521471 0.833333333333333 27.1 27 1 abnormal corticospinal tract morphology 0.000999890463452481 0.0100296137821439 1.50418940521471 0.833333333333333 27.1 27 1 abnormal AMPA-mediated synaptic currents 0.000999890463452481 0.0100296137821439 1.50418940521471 0.833333333333333 27.1 27 1 decreased synaptic depression 0.000999890463452481 0.0100296137821439 1.50418940521471 0.833333333333333 27.1 27 1 decreased red blood cell distribution width 0.000999890463452481 0.0100296137821439 1.50418940521471 0.833333333333333 27.1 27 1 persistent right dorsal aorta 0.000999890463452481 0.0100296137821439 1.50418940521471 0.833333333333333 27.1 27 1 embryonic lethality between implantation and placentation, incomplete penetrance 0.000999890463452481 0.0100296137821439 1.50418940521471 0.833333333333333 27.1 27 1 abnormal vitelline vein connection 0.000999890463452481 0.0100296137821439 1.50418940521471 0.833333333333333 27.1 27 1 absent superior cervical ganglion 0.0242764920918129 0.123803330028434 1.50418940521471 0.833333333333333 27.1 27 1 hyperresponsive 0.0242764920918129 0.123803330028434 1.50418940521471 0.833333333333333 27.1 27 1 absent ectoplacental cone 0.0242764920918129 0.123803330028434 1.50418940521471 0.833333333333333 27.1 27 1 non-obstructive hydrocephaly 0.0242764920918129 0.123803330028434 1.50418940521471 0.833333333333333 27.1 27 1 reduced NMDA-mediated synaptic currents 0.0242764920918129 0.123803330028434 1.50418940521471 0.833333333333333 27.1 27 1 abnormal hippocampal fimbria morphology 0.0242764920918129 0.123803330028434 1.50418940521471 0.833333333333333 27.1 27 1 abnormal intestinal peristalsis 0.0242764920918129 0.123803330028434 1.50418940521471 0.833333333333333 27.1 27 1 enlarged pancreas 0.0242764920918129 0.123803330028434 1.50418940521471 0.833333333333333 27.1 27 1 abnormal cholesterol level 0.0242764920918129 0.123803330028434 1.50418940521471 0.833333333333333 27.1 27 1 abnormal extensor digitorum longus morphology 0.0242764920918129 0.123803330028434 1.50418940521471 0.833333333333333 27.1 27 1 short scapula 0.0242764920918129 0.123803330028434 1.50418940521471 0.833333333333333 27.1 27 1 absent parietal bone 0.0242764920918129 0.123803330028434 1.50418940521471 0.833333333333333 27.1 27 1 decreased platelet ADP level 0.0242764920918129 0.123803330028434 1.50418940521471 0.833333333333333 27.1 27 1 abnormal neural crest cell morphology 0.0242764920918129 0.123803330028434 1.50418940521471 0.833333333333333 27.1 27 1 increased transitional stage T1 B cell number 0.0242764920918129 0.123803330028434 1.50418940521471 0.833333333333333 27.1 27 1 abnormal olfactory bulb layer morphology 0.0242764920918129 0.123803330028434 1.50418940521471 0.833333333333333 27.1 27 1 ectopic hippocampus pyramidal cells 0.0242764920918129 0.123803330028434 1.50418940521471 0.833333333333333 27.1 27 1 abnormal endocrine pancreas development 0.0242764920918129 0.123803330028434 1.50418940521471 0.833333333333333 27.1 27 1 increased CD11b-high dendritic cell number 0.0242764920918129 0.123803330028434 1.50418940521471 0.833333333333333 27.1 27 1 abnormal vertebral artery origin 0.0242764920918129 0.123803330028434 1.50418940521471 0.833333333333333 27.1 27 1 abnormal platelet alpha-granule morphology 0.0242764920918129 0.123803330028434 1.50418940521471 0.833333333333333 27.1 27 1 decreased tear production 0.0242764920918129 0.123803330028434 1.50418940521471 0.833333333333333 27.1 27 1 abnormal excitatory synapse morphology 0.0242764920918129 0.123803330028434 1.50418940521471 0.833333333333333 27.1 27 1 abnormal brain wave pattern 4.13369090530398e-12 3.02428121380696e-10 1.49261871748229 0.826923076923077 27.1 27 1 delayed hepatic development 0.00236152701722294 0.020256201570145 1.47684050693808 0.818181818181818 27.1 27 1 fatigue 0.00236152701722294 0.020256201570145 1.47684050693808 0.818181818181818 27.1 27 1 decreased post-tetanic potentiation 0.00236152701722294 0.020256201570145 1.47684050693808 0.818181818181818 27.1 27 1 cyclopia 0.00236152701722294 0.020256201570145 1.47684050693808 0.818181818181818 27.1 27 1 abnormal brain commissure morphology 1.39646078054316e-06 3.45641412099612e-05 1.47076297398771 0.814814814814815 27.1 27 1 increased cochlear outer hair cell number 0.000252055496367313 0.00330864404862106 1.46658467008434 0.8125 27.1 27 1 left pulmonary isomerism 2.81018326307289e-05 0.000500958212504316 1.46121256506572 0.80952380952381 27.1 27 1 abnormal object recognition memory 3.73552912291441e-07 1.06806076933903e-05 1.45566716633681 0.806451612903226 27.1 27 1 abnormal nest building behavior 7.33358991029225e-06 0.000152019207515433 1.44402182900612 0.8 27.1 27 1 decreased hepatocyte number 0.000580150284568909 0.00650055780569892 1.44402182900612 0.8 27.1 27 1 abnormal neurotransmitter secretion 0.000580150284568909 0.00650055780569892 1.44402182900612 0.8 27.1 27 1 abnormal cerebral aqueduct morphology 0.000580150284568909 0.00650055780569892 1.44402182900612 0.8 27.1 27 1 heterochrony 0.000580150284568909 0.00650055780569892 1.44402182900612 0.8 27.1 27 1 decreased paired-pulse facilitation 6.43438790271742e-05 0.00102599614794933 1.44402182900612 0.8 27.1 27 1 spleen atrophy 6.43438790271742e-05 0.00102599614794933 1.44402182900612 0.8 27.1 27 1 abnormal neuron proliferation 6.43438790271742e-05 0.00102599614794933 1.44402182900612 0.8 27.1 27 1 abnormal PNS synaptic transmission 0.00548756784607193 0.0406865127186406 1.44402182900612 0.8 27.1 27 1 abnormal tibialis anterior morphology 0.00548756784607193 0.0406865127186406 1.44402182900612 0.8 27.1 27 1 intestinal hypoperistalsis 0.00548756784607193 0.0406865127186406 1.44402182900612 0.8 27.1 27 1 abnormal deltoid tuberosity morphology 0.00548756784607193 0.0406865127186406 1.44402182900612 0.8 27.1 27 1 tachypnea 0.00548756784607193 0.0406865127186406 1.44402182900612 0.8 27.1 27 1 acanthocytosis 0.00548756784607193 0.0406865127186406 1.44402182900612 0.8 27.1 27 1 abnormal inferior vena cava valve morphology 0.00548756784607193 0.0406865127186406 1.44402182900612 0.8 27.1 27 1 abnormal circadian temperature homeostasis 0.00548756784607193 0.0406865127186406 1.44402182900612 0.8 27.1 27 1 increased mortality induced by gamma-irradiation 1.92225446153996e-06 4.59769997411601e-05 1.43157336496296 0.793103448275862 27.1 27 1 kyphoscoliosis 0.000145724810629133 0.00203646329460657 1.42502154178235 0.789473684210526 27.1 27 1 increased lactate dehydrogenase level 0.00131674657179082 0.012695376346239 1.41823572491672 0.785714285714286 27.1 27 1 testis degeneration 0.00131674657179082 0.012695376346239 1.41823572491672 0.785714285714286 27.1 27 1 abnormal lysosome morphology 2.95657008086849e-07 8.65231538371808e-06 1.40391011153373 0.777777777777778 27.1 27 1 delayed kidney development 0.000326050304222138 0.00405525065876284 1.40391011153373 0.777777777777778 27.1 27 1 increased effector memory CD4-positive, alpha-beta T cell number 0.000326050304222138 0.00405525065876284 1.40391011153373 0.777777777777778 27.1 27 1 increased adipocyte glucose uptake 0.000326050304222138 0.00405525065876284 1.40391011153373 0.777777777777778 27.1 27 1 abnormal sympathetic neuron morphology 0.0125044652511905 0.0764066599841289 1.40391011153373 0.777777777777778 27.1 27 1 abnormal artery development 0.0125044652511905 0.0764066599841289 1.40391011153373 0.777777777777778 27.1 27 1 decreased fear-related response 0.0125044652511905 0.0764066599841289 1.40391011153373 0.777777777777778 27.1 27 1 abnormal thymus physiology 0.0125044652511905 0.0764066599841289 1.40391011153373 0.777777777777778 27.1 27 1 decreased cellular sensitivity to ionizing radiation 0.0125044652511905 0.0764066599841289 1.40391011153373 0.777777777777778 27.1 27 1 positive geotaxis 0.0125044652511905 0.0764066599841289 1.40391011153373 0.777777777777778 27.1 27 1 enhanced conditioned place preference behavior 0.0125044652511905 0.0764066599841289 1.40391011153373 0.777777777777778 27.1 27 1 abnormal optic chiasm morphology 0.0125044652511905 0.0764066599841289 1.40391011153373 0.777777777777778 27.1 27 1 abnormal liver vasculature morphology 0.0125044652511905 0.0764066599841289 1.40391011153373 0.777777777777778 27.1 27 1 abnormal cerebellar layer morphology 0.0125044652511905 0.0764066599841289 1.40391011153373 0.777777777777778 27.1 27 1 abnormal ventricle myocardium morphology 0.0125044652511905 0.0764066599841289 1.40391011153373 0.777777777777778 27.1 27 1 reduced AMPA-mediated synaptic currents 0.0125044652511905 0.0764066599841289 1.40391011153373 0.777777777777778 27.1 27 1 abnormal infrahyoid muscle connection 0.0125044652511905 0.0764066599841289 1.40391011153373 0.777777777777778 27.1 27 1 abnormal coronary sinus connection 0.0125044652511905 0.0764066599841289 1.40391011153373 0.777777777777778 27.1 27 1 increased cardiac muscle glycogen level 0.0125044652511905 0.0764066599841289 1.40391011153373 0.777777777777778 27.1 27 1 increased startle reflex 7.889247474357e-16 9.81225154623151e-14 1.39940317698627 0.775280898876405 27.1 27 1 atrioventricular septal defect 6.65641639019417e-10 3.27877936051643e-08 1.39634186295403 0.773584905660377 27.1 27 1 omphalocele 2.06147816845842e-08 8.01238585006299e-07 1.39479381210818 0.772727272727273 27.1 27 1 abnormal tail movements 8.23292471008439e-05 0.00124117577068697 1.39479381210818 0.772727272727273 27.1 27 1 abnormal lysosome physiology 8.23292471008439e-05 0.00124117577068697 1.39479381210818 0.772727272727273 27.1 27 1 abnormal nerve conduction 2.10674790083817e-05 0.00039402521829586 1.3884825278905 0.769230769230769 27.1 27 1 abnormal tail bud morphology 0.00294084089425172 0.024589383947735 1.3884825278905 0.769230769230769 27.1 27 1 abnormal exocrine pancreas morphology 0.00294084089425172 0.024589383947735 1.3884825278905 0.769230769230769 27.1 27 1 increased cellular sensitivity to gamma-irradiation 1.18984180556268e-08 4.81257153062954e-07 1.3825740916016 0.765957446808511 27.1 27 1 abnormal glutamate-mediated receptor currents 0.000719678621417647 0.00781746974138165 1.38031498360879 0.764705882352941 27.1 27 1 abnormal ectoplacental cone morphology 0.000719678621417647 0.00781746974138165 1.38031498360879 0.764705882352941 27.1 27 1 enhanced behavioral response to cocaine 0.000719678621417647 0.00781746974138165 1.38031498360879 0.764705882352941 27.1 27 1 abnormal ductus venosus valve morphology 0.000719678621417647 0.00781746974138165 1.38031498360879 0.764705882352941 27.1 27 1 increased grooming behavior 3.70843357802075e-07 1.066442604084e-05 1.37752082372294 0.763157894736842 27.1 27 1 abnormal salivary gland morphology 0.000180318427495799 0.00243772874128152 1.37525888476773 0.761904761904762 27.1 27 1 absent segment of posterior cerebral artery 0.000180318427495799 0.00243772874128152 1.37525888476773 0.761904761904762 27.1 27 1 increased cellular sensitivity to ionizing radiation 4.58897063936165e-05 0.000758476044213429 1.37182073755581 0.76 27.1 27 1 axon degeneration 1.80847575447556e-09 8.25428153992287e-08 1.37048368030673 0.759259259259259 27.1 27 1 absent long term depression 1.18085502882823e-05 0.00023405393499683 1.36933104474718 0.758620689655172 27.1 27 1 ataxia 1.42213405589336e-30 5.44239763697653e-28 1.35823835401566 0.752475247524752 27.1 27 1 reduced male mating frequency 0.0015644346491737 0.0148531724802274 1.35377046469324 0.75 27.1 27 1 increased intestinal adenocarcinoma incidence 0.0015644346491737 0.0148531724802274 1.35377046469324 0.75 27.1 27 1 decreased aggression towards mice 0.0015644346491737 0.0148531724802274 1.35377046469324 0.75 27.1 27 1 dystonia 0.0015644346491737 0.0148531724802274 1.35377046469324 0.75 27.1 27 1 impaired somite development 0.0015644346491737 0.0148531724802274 1.35377046469324 0.75 27.1 27 1 decreased liver cholesterol level 0.0015644346491737 0.0148531724802274 1.35377046469324 0.75 27.1 27 1 increased sensitivity to skin irradiation 0.0278166805653879 0.131547515031184 1.35377046469324 0.75 27.1 27 1 dry eyes 0.0278166805653879 0.131547515031184 1.35377046469324 0.75 27.1 27 1 spinning 0.0278166805653879 0.131547515031184 1.35377046469324 0.75 27.1 27 1 poor grooming 0.0278166805653879 0.131547515031184 1.35377046469324 0.75 27.1 27 1 abnormal urination 0.0278166805653879 0.131547515031184 1.35377046469324 0.75 27.1 27 1 decreased aerobic running capacity 0.0278166805653879 0.131547515031184 1.35377046469324 0.75 27.1 27 1 abnormal cellular cholesterol metabolism 0.0278166805653879 0.131547515031184 1.35377046469324 0.75 27.1 27 1 abnormal neuron apoptosis 0.0278166805653879 0.131547515031184 1.35377046469324 0.75 27.1 27 1 liver failure 0.0278166805653879 0.131547515031184 1.35377046469324 0.75 27.1 27 1 liver cysts 0.0278166805653879 0.131547515031184 1.35377046469324 0.75 27.1 27 1 abnormal eyelid aperture 0.0278166805653879 0.131547515031184 1.35377046469324 0.75 27.1 27 1 elevated level of mitotic sister chromatid exchange 0.0278166805653879 0.131547515031184 1.35377046469324 0.75 27.1 27 1 tau protein deposits 0.0278166805653879 0.131547515031184 1.35377046469324 0.75 27.1 27 1 absent interparietal bone 0.0278166805653879 0.131547515031184 1.35377046469324 0.75 27.1 27 1 abnormal kidney epithelium morphology 0.0278166805653879 0.131547515031184 1.35377046469324 0.75 27.1 27 1 accumulation of giant lysosomes in kidney/renal tubule cells 0.0278166805653879 0.131547515031184 1.35377046469324 0.75 27.1 27 1 abnormal somite size 0.0278166805653879 0.131547515031184 1.35377046469324 0.75 27.1 27 1 increased pulmonary ventilation 0.0278166805653879 0.131547515031184 1.35377046469324 0.75 27.1 27 1 abnormal olfactory bulb mitral cell layer morphology 0.0278166805653879 0.131547515031184 1.35377046469324 0.75 27.1 27 1 abnormal cerebellum deep nucleus morphology 0.0278166805653879 0.131547515031184 1.35377046469324 0.75 27.1 27 1 abnormal hepatic vein morphology 0.0278166805653879 0.131547515031184 1.35377046469324 0.75 27.1 27 1 myocardial trabeculae hypoplasia 0.0278166805653879 0.131547515031184 1.35377046469324 0.75 27.1 27 1 abnormal visual evoked potential 0.0278166805653879 0.131547515031184 1.35377046469324 0.75 27.1 27 1 abnormal stomach position or orientation 0.0278166805653879 0.131547515031184 1.35377046469324 0.75 27.1 27 1 abnormal anterior commissure pars posterior morphology 0.0278166805653879 0.131547515031184 1.35377046469324 0.75 27.1 27 1 abnormal foramen magnum morphology 0.0278166805653879 0.131547515031184 1.35377046469324 0.75 27.1 27 1 increased aorta wall thickness 0.0278166805653879 0.131547515031184 1.35377046469324 0.75 27.1 27 1 decreased cranium length 0.0278166805653879 0.131547515031184 1.35377046469324 0.75 27.1 27 1 increased circulating lactate level 0.0278166805653879 0.131547515031184 1.35377046469324 0.75 27.1 27 1 increased mammary gland apoptosis 0.0278166805653879 0.131547515031184 1.35377046469324 0.75 27.1 27 1 decreased white adipose tissue mass 0.0278166805653879 0.131547515031184 1.35377046469324 0.75 27.1 27 1 increased brain apoptosis 0.0278166805653879 0.131547515031184 1.35377046469324 0.75 27.1 27 1 abnormal posture 7.97091807566742e-13 7.08130668329383e-11 1.35377046469324 0.75 27.1 27 1 kinked neural tube 8.26317105776759e-09 3.42577300103282e-07 1.35377046469324 0.75 27.1 27 1 subcutaneous edema 2.53653611377811e-05 0.000458882442401676 1.35377046469324 0.75 27.1 27 1 ocular hypertelorism 9.88460662363096e-05 0.00145490881516462 1.35377046469324 0.75 27.1 27 1 abnormal retinal ganglion layer morphology 9.88460662363096e-05 0.00145490881516462 1.35377046469324 0.75 27.1 27 1 anencephaly 0.00038986760543501 0.00474227710767524 1.35377046469324 0.75 27.1 27 1 absent ductus venosus valve 0.00038986760543501 0.00474227710767524 1.35377046469324 0.75 27.1 27 1 abnormal enteric nervous system morphology 0.00644643667853431 0.04607905528119 1.35377046469324 0.75 27.1 27 1 abnormal mating frequency 0.00644643667853431 0.04607905528119 1.35377046469324 0.75 27.1 27 1 abnormal thymus involution 0.00644643667853431 0.04607905528119 1.35377046469324 0.75 27.1 27 1 abnormal vascular endothelial cell development 0.00644643667853431 0.04607905528119 1.35377046469324 0.75 27.1 27 1 increased osteosarcoma incidence 0.00644643667853431 0.04607905528119 1.35377046469324 0.75 27.1 27 1 abnormal amacrine cell morphology 0.00644643667853431 0.04607905528119 1.35377046469324 0.75 27.1 27 1 abnormal somatic nervous system physiology 0.00644643667853431 0.04607905528119 1.35377046469324 0.75 27.1 27 1 decreased mammary gland epithelial cell proliferation 0.00644643667853431 0.04607905528119 1.35377046469324 0.75 27.1 27 1 abnormal hippocampus pyramidal cell morphology 3.63257117367355e-06 8.15068194601608e-05 1.34087741264854 0.742857142857143 27.1 27 1 decreased thymus weight 1.39449335878158e-05 0.000268233049646323 1.33921379302987 0.741935483870968 27.1 27 1 increased B cell derived lymphoma incidence 3.68529239595378e-08 1.32684634868507e-06 1.33572019183066 0.74 27.1 27 1 decreased respiratory quotient 3.68529239595378e-08 1.32684634868507e-06 1.33572019183066 0.74 27.1 27 1 failure to gastrulate 1.39119361628435e-07 4.40840015351251e-06 1.33415060288609 0.739130434782609 27.1 27 1 double outlet right ventricle 8.94050042370986e-16 1.08485340507211e-13 1.33268369733041 0.738317757009346 27.1 27 1 abnormal nervous system electrophysiology 1.12512868492392e-12 9.48731391101104e-11 1.33228204461874 0.738095238095238 27.1 27 1 abnormal neuron morphology 1.23102338542201e-14 1.3918957596533e-12 1.33097971612938 0.737373737373737 27.1 27 1 decreased brain weight 5.45416045255054e-09 2.35951723925556e-07 1.33002010566353 0.736842105263158 27.1 27 1 delayed sexual maturation 0.000830961686282547 0.00879581784948015 1.33002010566353 0.736842105263158 27.1 27 1 increased malignant tumor incidence 0.000830961686282547 0.00879581784948015 1.33002010566353 0.736842105263158 27.1 27 1 increased liver adenoma incidence 0.000830961686282547 0.00879581784948015 1.33002010566353 0.736842105263158 27.1 27 1 abnormal response to new environment 2.93128648781701e-05 0.000517132988542186 1.32368667658894 0.733333333333333 27.1 27 1 abnormal pup retrieval 0.00334238636165108 0.0274849126433291 1.32368667658894 0.733333333333333 27.1 27 1 delayed intramembranous bone ossification 0.00334238636165108 0.0274849126433291 1.32368667658894 0.733333333333333 27.1 27 1 abnormal glial cell morphology 0.00334238636165108 0.0274849126433291 1.32368667658894 0.733333333333333 27.1 27 1 abnormal myocardial trabeculae morphology 2.90719140500993e-07 8.55815221297301e-06 1.32368667658894 0.733333333333333 27.1 27 1 ventricular hypoplasia 0.000113264323582109 0.00164763160766372 1.31905840149597 0.730769230769231 27.1 27 1 abnormal Mullerian duct morphology 0.000113264323582109 0.00164763160766372 1.31905840149597 0.730769230769231 27.1 27 1 gliosis 1.68135991586909e-09 7.74515331615625e-08 1.31795643123574 0.73015873015873 27.1 27 1 abnormal head morphology 2.34906329444636e-08 8.770554363678e-07 1.31274711727829 0.727272727272727 27.1 27 1 abnormal contextual conditioning behavior 2.34906329444636e-08 8.770554363678e-07 1.31274711727829 0.727272727272727 27.1 27 1 abnormal learning/memory/conditioning 2.34906329444636e-08 8.770554363678e-07 1.31274711727829 0.727272727272727 27.1 27 1 decreased circulating total protein level 2.34906329444636e-08 8.770554363678e-07 1.31274711727829 0.727272727272727 27.1 27 1 decreased brown adipose tissue amount 1.59099676071115e-05 0.000303264708219845 1.31274711727829 0.727272727272727 27.1 27 1 lethality, incomplete penetrance 6.02975471638215e-07 1.63032770184789e-05 1.31274711727829 0.727272727272727 27.1 27 1 increased body size 0.000441622908549011 0.00531979169499111 1.31274711727829 0.727272727272727 27.1 27 1 abnormal vascular branching morphogenesis 0.000441622908549011 0.00531979169499111 1.31274711727829 0.727272727272727 27.1 27 1 abnormal sebaceous gland morphology 0.0138236767230026 0.0823626247867518 1.31274711727829 0.727272727272727 27.1 27 1 abnormal enteric ganglia morphology 0.0138236767230026 0.0823626247867518 1.31274711727829 0.727272727272727 27.1 27 1 loss of cortex neurons 0.0138236767230026 0.0823626247867518 1.31274711727829 0.727272727272727 27.1 27 1 abnormal radial glial cell morphology 0.0138236767230026 0.0823626247867518 1.31274711727829 0.727272727272727 27.1 27 1 abnormal spinal cord ventral horn morphology 0.0138236767230026 0.0823626247867518 1.31274711727829 0.727272727272727 27.1 27 1 thin hypoglossal nerve 0.0138236767230026 0.0823626247867518 1.31274711727829 0.727272727272727 27.1 27 1 reduced sympathetic cervical ganglion size 0.0138236767230026 0.0823626247867518 1.31274711727829 0.727272727272727 27.1 27 1 impaired balance 3.39789408284783e-14 3.59670703450382e-12 1.30952959983398 0.725490196078431 27.1 27 1 blood in lymph vessels 6.09519896177155e-05 0.000984532949182255 1.3070887245314 0.724137931034483 27.1 27 1 abnormal spatial learning 1.20987503738615e-21 2.61701230912873e-19 1.30670686980615 0.723926380368098 27.1 27 1 abnormal cell nucleus morphology 3.30095277283177e-07 9.54781397955702e-06 1.30576441984596 0.723404255319149 27.1 27 1 hydrops fetalis 2.83947353697734e-10 1.48698745752235e-08 1.30363081785275 0.722222222222222 27.1 27 1 right pulmonary isomerism 0.00174311224612598 0.0160890230509773 1.30363081785275 0.722222222222222 27.1 27 1 absent spleen 0.00174311224612598 0.0160890230509773 1.30363081785275 0.722222222222222 27.1 27 1 abnormal bile duct morphology 0.00174311224612598 0.0160890230509773 1.30363081785275 0.722222222222222 27.1 27 1 decreased lactate dehydrogenase level 0.00174311224612598 0.0160890230509773 1.30363081785275 0.722222222222222 27.1 27 1 increased effector memory CD8-positive, alpha-beta T cell number 0.00174311224612598 0.0160890230509773 1.30363081785275 0.722222222222222 27.1 27 1 ventricular septal defect 5.39445880560748e-18 8.38669767434288e-16 1.30068142686213 0.720588235294118 27.1 27 1 short stride length 1.80495619129868e-07 5.61228565731933e-06 1.29961964610551 0.72 27.1 27 1 limb grasping 1.73766750777443e-23 4.11661707198941e-21 1.29922293681182 0.71978021978022 27.1 27 1 abnormal long term potentiation 3.27989469129268e-05 0.000570541121999338 1.29736336199768 0.71875 27.1 27 1 abnormal spongiotrophoblast layer morphology 3.27989469129268e-05 0.000570541121999338 1.29736336199768 0.71875 27.1 27 1 abnormal auditory brainstem response waveform shape 3.27989469129268e-05 0.000570541121999338 1.29736336199768 0.71875 27.1 27 1 atrial septal defect 6.75549348408259e-07 1.81668000450329e-05 1.29491087927179 0.717391304347826 27.1 27 1 abnormal motor coordination/ balance 2.88737831039697e-13 2.71032209324998e-11 1.2945145184272 0.717171717171717 27.1 27 1 increased neuron apoptosis 4.74412109330804e-11 2.91382746163055e-09 1.29248867411041 0.716049382716049 27.1 27 1 abnormal erythropoiesis 8.77779819488144e-14 8.73390920390703e-12 1.28930520446975 0.714285714285714 27.1 27 1 myoclonus 0.000125269647948768 0.00179085200731357 1.28930520446975 0.714285714285714 27.1 27 1 abnormal eye pigmentation 0.00091374055028304 0.00953010322360193 1.28930520446975 0.714285714285714 27.1 27 1 abnormal associative learning 0.00091374055028304 0.00953010322360193 1.28930520446975 0.714285714285714 27.1 27 1 abnormal embryonic/fetal subventricular zone morphology 0.00091374055028304 0.00953010322360193 1.28930520446975 0.714285714285714 27.1 27 1 midline facial cleft 0.00700107670040399 0.0485102459394288 1.28930520446975 0.714285714285714 27.1 27 1 abnormal blood flow velocity 0.00700107670040399 0.0485102459394288 1.28930520446975 0.714285714285714 27.1 27 1 translucent skin 0.00700107670040399 0.0485102459394288 1.28930520446975 0.714285714285714 27.1 27 1 increased hemangioma incidence 0.00700107670040399 0.0485102459394288 1.28930520446975 0.714285714285714 27.1 27 1 absent olfactory bulb 0.00700107670040399 0.0485102459394288 1.28930520446975 0.714285714285714 27.1 27 1 abnormal viscerocranium morphology 0.00700107670040399 0.0485102459394288 1.28930520446975 0.714285714285714 27.1 27 1 decreased response to antigen 0.00700107670040399 0.0485102459394288 1.28930520446975 0.714285714285714 27.1 27 1 maxilla hypoplasia 0.0600357905783948 0.213189192096727 1.28930520446975 0.714285714285714 27.1 27 1 mammary gland hyperplasia 0.0600357905783948 0.213189192096727 1.28930520446975 0.714285714285714 27.1 27 1 abnormal lacrimal gland morphology 0.0600357905783948 0.213189192096727 1.28930520446975 0.714285714285714 27.1 27 1 absent amniotic folds 0.0600357905783948 0.213189192096727 1.28930520446975 0.714285714285714 27.1 27 1 abnormal tumor incidence 0.0600357905783948 0.213189192096727 1.28930520446975 0.714285714285714 27.1 27 1 abnormal adrenal gland physiology 0.0600357905783948 0.213189192096727 1.28930520446975 0.714285714285714 27.1 27 1 decreased mortality induced by ionizing radiation 0.0600357905783948 0.213189192096727 1.28930520446975 0.714285714285714 27.1 27 1 absent tunnel of Corti 0.0600357905783948 0.213189192096727 1.28930520446975 0.714285714285714 27.1 27 1 decreased cardiomyocyte apoptosis 0.0600357905783948 0.213189192096727 1.28930520446975 0.714285714285714 27.1 27 1 abnormal talus morphology 0.0600357905783948 0.213189192096727 1.28930520446975 0.714285714285714 27.1 27 1 atherosclerotic lesions 0.0600357905783948 0.213189192096727 1.28930520446975 0.714285714285714 27.1 27 1 abnormal body temperature 0.0600357905783948 0.213189192096727 1.28930520446975 0.714285714285714 27.1 27 1 abnormal cerebellum white matter morphology 0.0600357905783948 0.213189192096727 1.28930520446975 0.714285714285714 27.1 27 1 arteritis 0.0600357905783948 0.213189192096727 1.28930520446975 0.714285714285714 27.1 27 1 heart block 0.0600357905783948 0.213189192096727 1.28930520446975 0.714285714285714 27.1 27 1 thick pulmonary valve 0.0600357905783948 0.213189192096727 1.28930520446975 0.714285714285714 27.1 27 1 abnormal impulsive behavior control 0.0600357905783948 0.213189192096727 1.28930520446975 0.714285714285714 27.1 27 1 decreased areal bone mineral density 0.0600357905783948 0.213189192096727 1.28930520446975 0.714285714285714 27.1 27 1 abnormal Mullerian duct topology 0.0600357905783948 0.213189192096727 1.28930520446975 0.714285714285714 27.1 27 1 embryo tumor 0.0600357905783948 0.213189192096727 1.28930520446975 0.714285714285714 27.1 27 1 decreased collagen level 0.0600357905783948 0.213189192096727 1.28930520446975 0.714285714285714 27.1 27 1 abnormal postnatal growth/weight/body size 6.68789191434807e-05 0.00106301157424542 1.2809871063764 0.709677419354839 27.1 27 1 overriding aortic valve 7.42989219098862e-07 1.98729643280475e-05 1.2785609944325 0.708333333333333 27.1 27 1 increased hemangiosarcoma incidence 0.00048108350429462 0.00573954540495379 1.2785609944325 0.708333333333333 27.1 27 1 abnormal excitatory postsynaptic potential 1.05669745391991e-10 6.25841646815661e-09 1.27672661710907 0.707317073170732 27.1 27 1 lethality at weaning, incomplete penetrance 5.12258490989354e-06 0.000111287597933277 1.27672661710907 0.707317073170732 27.1 27 1 abnormal CNS synaptic transmission 1.29917699498574e-12 1.07723425834234e-10 1.27628191957612 0.707070707070707 27.1 27 1 impaired synaptic plasticity 3.5760685153411e-05 0.000617741002216041 1.27413690794658 0.705882352941177 27.1 27 1 hyperlipidemia 0.00359184911578822 0.0291033377052873 1.27413690794658 0.705882352941177 27.1 27 1 abnormal dorsal-ventral axis patterning 0.00359184911578822 0.0291033377052873 1.27413690794658 0.705882352941177 27.1 27 1 abnormal embryonic-extraembryonic boundary morphology 0.00359184911578822 0.0291033377052873 1.27413690794658 0.705882352941177 27.1 27 1 increased brain size 0.00359184911578822 0.0291033377052873 1.27413690794658 0.705882352941177 27.1 27 1 increased circulating magnesium level 0.00359184911578822 0.0291033377052873 1.27413690794658 0.705882352941177 27.1 27 1 abnormal cued conditioning behavior 4.02521411501781e-07 1.13780910353486e-05 1.27413690794658 0.705882352941177 27.1 27 1 abnormal excitatory postsynaptic currents 3.86755204968048e-10 1.98361561310932e-08 1.27277565056629 0.705128205128205 27.1 27 1 decreased susceptibility to pharmacologically induced seizures 0.000254232164765649 0.00331969821445959 1.27020438662575 0.703703703703704 27.1 27 1 decreased caudal vertebrae number 1.74758904470708e-08 6.84587047040765e-07 1.26915981064991 0.703125 27.1 27 1 neuron degeneration 1.48983394463165e-06 3.66926924482301e-05 1.26735958396814 0.702127659574468 27.1 27 1 kyphosis 1.09032423544642e-17 1.59540090333705e-15 1.26351910038035 0.7 27.1 27 1 embryonic lethality between somite formation and embryo turning, complete penetrance 5.16570322106492e-09 2.27428084290247e-07 1.26351910038035 0.7 27.1 27 1 abnormal axon extension 8.04171022629842e-07 2.12805895616142e-05 1.26351910038035 0.7 27.1 27 1 abnormal circulating enzyme level 0.00186018120826014 0.0168568333535414 1.26351910038035 0.7 27.1 27 1 abnormal sperm mitochondrial sheath morphology 0.00186018120826014 0.0168568333535414 1.26351910038035 0.7 27.1 27 1 retarded hair growth 0.0288772258631338 0.132287475754227 1.26351910038035 0.7 27.1 27 1 abnormal optic nerve innervation 0.0288772258631338 0.132287475754227 1.26351910038035 0.7 27.1 27 1 peritoneal inflammation 0.0288772258631338 0.132287475754227 1.26351910038035 0.7 27.1 27 1 absent seminal vesicle 0.0288772258631338 0.132287475754227 1.26351910038035 0.7 27.1 27 1 abnormal submandibular gland morphology 0.0288772258631338 0.132287475754227 1.26351910038035 0.7 27.1 27 1 increased heart rate variability 0.0288772258631338 0.132287475754227 1.26351910038035 0.7 27.1 27 1 abnormal gas homeostasis 0.0288772258631338 0.132287475754227 1.26351910038035 0.7 27.1 27 1 abnormal embryonic erythrocyte morphology 0.0288772258631338 0.132287475754227 1.26351910038035 0.7 27.1 27 1 ascites 0.0288772258631338 0.132287475754227 1.26351910038035 0.7 27.1 27 1 osteosclerosis 0.0288772258631338 0.132287475754227 1.26351910038035 0.7 27.1 27 1 abnormal spinal cord dorsal column morphology 0.0288772258631338 0.132287475754227 1.26351910038035 0.7 27.1 27 1 ventricular premature beat 0.0288772258631338 0.132287475754227 1.26351910038035 0.7 27.1 27 1 protruding tongue 0.0288772258631338 0.132287475754227 1.26351910038035 0.7 27.1 27 1 abnormal cerebellar granule cell migration 0.0288772258631338 0.132287475754227 1.26351910038035 0.7 27.1 27 1 increased serotonin level 0.0288772258631338 0.132287475754227 1.26351910038035 0.7 27.1 27 1 aorta stenosis 0.0288772258631338 0.132287475754227 1.26351910038035 0.7 27.1 27 1 thick aortic valve cusps 0.0288772258631338 0.132287475754227 1.26351910038035 0.7 27.1 27 1 thick aortic valve 0.0288772258631338 0.132287475754227 1.26351910038035 0.7 27.1 27 1 lethality during fetal growth through weaning, complete penetrance 0.0288772258631338 0.132287475754227 1.26351910038035 0.7 27.1 27 1 abnormal neural tube morphology 9.79219210687344e-19 1.67986743902398e-16 1.25906224288342 0.697530864197531 27.1 27 1 decreased circulating serum albumin level 5.57360775014355e-12 3.96124265099488e-10 1.25804932072503 0.696969696969697 27.1 27 1 abnormal somite development 8.30508283904411e-10 4.05076344355338e-08 1.25666456638191 0.69620253164557 27.1 27 1 embryonic lethality between implantation and placentation, complete penetrance 2.96259407986708e-06 6.91967396588672e-05 1.25567115565749 0.695652173913043 27.1 27 1 abnormal axon morphology 9.04320782943085e-13 7.89297525463482e-11 1.25349117101226 0.694444444444444 27.1 27 1 reduced long term depression 3.81732473985768e-05 0.000652618233016906 1.25349117101226 0.694444444444444 27.1 27 1 abnormal trophoblast giant cell morphology 3.81732473985768e-05 0.000652618233016906 1.25349117101226 0.694444444444444 27.1 27 1 prenatal lethality 6.86348182958526e-08 2.26131272199912e-06 1.25187376304966 0.693548387096774 27.1 27 1 small liver 1.63420260610424e-09 7.5982784723071e-08 1.24963427510145 0.692307692307692 27.1 27 1 short premaxilla 0.0143340271931701 0.0836992785047199 1.24963427510145 0.692307692307692 27.1 27 1 excessive scratching 0.0143340271931701 0.0836992785047199 1.24963427510145 0.692307692307692 27.1 27 1 abnormal digestion 0.0143340271931701 0.0836992785047199 1.24963427510145 0.692307692307692 27.1 27 1 increased synaptic depression 0.0143340271931701 0.0836992785047199 1.24963427510145 0.692307692307692 27.1 27 1 abnormal retinal inner plexiform layer morphology 0.0143340271931701 0.0836992785047199 1.24963427510145 0.692307692307692 27.1 27 1 increased cochlear inner hair cell number 0.0143340271931701 0.0836992785047199 1.24963427510145 0.692307692307692 27.1 27 1 abnormal vertebral arch development 0.0143340271931701 0.0836992785047199 1.24963427510145 0.692307692307692 27.1 27 1 abnormal aorta tunica media morphology 0.0143340271931701 0.0836992785047199 1.24963427510145 0.692307692307692 27.1 27 1 impaired coordination 6.44075958042965e-37 3.56030876807083e-34 1.2468252064034 0.690751445086705 27.1 27 1 preweaning lethality, complete penetrance 9.2449285580373e-78 2.29967597881178e-74 1.24644451794278 0.690540540540541 27.1 27 1 abnormal brain morphology 7.92976918798626e-18 1.19547277909793e-15 1.24445980605341 0.68944099378882 27.1 27 1 trabecula carnea hypoplasia 5.8399037323945e-06 0.000124693223470655 1.24346324164416 0.688888888888889 27.1 27 1 decreased circulating LDL cholesterol level 7.2737924002913e-08 2.36993447069238e-06 1.24095625930213 0.6875 27.1 27 1 scoliosis 0.0001418548580507 0.00199358169153172 1.24095625930213 0.6875 27.1 27 1 abnormal depression-related behavior 0.0001418548580507 0.00199358169153172 1.24095625930213 0.6875 27.1 27 1 pancreatic islet hyperplasia 0.0001418548580507 0.00199358169153172 1.24095625930213 0.6875 27.1 27 1 increased fibroblast apoptosis 0.0001418548580507 0.00199358169153172 1.24095625930213 0.6875 27.1 27 1 abnormal olfaction 0.00725388012910132 0.0492054019052724 1.24095625930213 0.6875 27.1 27 1 blepharitis 0.00725388012910132 0.0492054019052724 1.24095625930213 0.6875 27.1 27 1 embryonic lethality between somite formation and embryo turning, incomplete penetrance 0.00725388012910132 0.0492054019052724 1.24095625930213 0.6875 27.1 27 1 abnormal gastrulation 1.68277954697247e-06 4.0838186566771e-05 1.23874421605917 0.686274509803922 27.1 27 1 abnormal response to novel object 1.68277954697247e-06 4.0838186566771e-05 1.23874421605917 0.686274509803922 27.1 27 1 abnormal gait 3.06491336284113e-32 1.38617672546678e-29 1.23840059769133 0.686084142394822 27.1 27 1 abnormal embryonic epiblast morphology 7.52650987193564e-05 0.00117380522297429 1.23773299629096 0.685714285714286 27.1 27 1 anophthalmia 2.76823080089389e-10 1.46510087600501e-08 1.23715353327771 0.685393258426966 27.1 27 1 neurodegeneration 9.04886823500917e-07 2.36937470890372e-05 1.23677795539876 0.685185185185185 27.1 27 1 seizures 1.08443551117858e-12 9.30183908295417e-11 1.23501866954471 0.684210526315789 27.1 27 1 abnormal stationary movement 0.00371943845912008 0.029512290804023 1.23501866954471 0.684210526315789 27.1 27 1 unresponsive to tactile stimuli 0.00371943845912008 0.029512290804023 1.23501866954471 0.684210526315789 27.1 27 1 decreased germ cell number 0.00371943845912008 0.029512290804023 1.23501866954471 0.684210526315789 27.1 27 1 oliguria 0.00371943845912008 0.029512290804023 1.23501866954471 0.684210526315789 27.1 27 1 increased circulating VLDL cholesterol level 0.00371943845912008 0.029512290804023 1.23501866954471 0.684210526315789 27.1 27 1 Leydig cell hypoplasia 0.00371943845912008 0.029512290804023 1.23501866954471 0.684210526315789 27.1 27 1 abnormal behavioral response to xenobiotic 0.00371943845912008 0.029512290804023 1.23501866954471 0.684210526315789 27.1 27 1 increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 0.00371943845912008 0.029512290804023 1.23501866954471 0.684210526315789 27.1 27 1 embryonic lethality between implantation and somite formation, incomplete penetrance 0.00371943845912008 0.029512290804023 1.23501866954471 0.684210526315789 27.1 27 1 absent mesoderm 2.62418649691433e-07 7.81756157014897e-06 1.23343531227606 0.683333333333333 27.1 27 1 Leydig cell hyperplasia 2.13497111470619e-05 0.00039485060578674 1.23270156134669 0.682926829268293 27.1 27 1 thick ventricular wall 2.13497111470619e-05 0.00039485060578674 1.23270156134669 0.682926829268293 27.1 27 1 hyperactivity 1.62967560372212e-37 1.01345451606469e-34 1.23092157256923 0.681940700808625 27.1 27 1 decreased cardiac output 0.00192542121114167 0.0171666138448563 1.2307004224484 0.681818181818182 27.1 27 1 abnormal limb posture 0.00192542121114167 0.0171666138448563 1.2307004224484 0.681818181818182 27.1 27 1 cleft upper lip 0.00192542121114167 0.0171666138448563 1.2307004224484 0.681818181818182 27.1 27 1 abnormal occipital bone morphology 0.00192542121114167 0.0171666138448563 1.2307004224484 0.681818181818182 27.1 27 1 increased bone volume 0.00192542121114167 0.0171666138448563 1.2307004224484 0.681818181818182 27.1 27 1 abnormal embryo size 2.0963763820439e-12 1.70974959027351e-10 1.229974345503 0.68141592920354 27.1 27 1 abnormal locomotor activation 2.90789292791498e-10 1.50695492878927e-08 1.2297988104173 0.681318681318681 27.1 27 1 decreased cell proliferation 2.45158021882725e-19 4.3559327102377e-17 1.22936993550521 0.681081081081081 27.1 27 1 pallor 2.92468947290691e-18 4.82726827978027e-16 1.2274185546552 0.68 27.1 27 1 abnormal primitive streak morphology 0.00100396937959953 0.0100296137821439 1.2274185546552 0.68 27.1 27 1 embryonic lethality before implantation, complete penetrance 1.83093356850047e-13 1.75171048140189e-11 1.2274185546552 0.68 27.1 27 1 absent gastric milk in neonates 6.51386128420574e-09 2.74631016007827e-07 1.22649289963661 0.67948717948718 27.1 27 1 increased bone mineral content 7.43166810399489e-12 5.20740124188374e-10 1.22543136865198 0.678899082568807 27.1 27 1 shortened head 0.000526486366934618 0.00607719182250516 1.22483994424626 0.678571428571429 27.1 27 1 lymphoid hyperplasia 0.000526486366934618 0.00607719182250516 1.22483994424626 0.678571428571429 27.1 27 1 small superior cervical ganglion 0.000526486366934618 0.00607719182250516 1.22483994424626 0.678571428571429 27.1 27 1 absent corpus callosum 0.000526486366934618 0.00607719182250516 1.22483994424626 0.678571428571429 27.1 27 1 increased bone resorption 0.000526486366934618 0.00607719182250516 1.22483994424626 0.678571428571429 27.1 27 1 hypoxia 0.000526486366934618 0.00607719182250516 1.22483994424626 0.678571428571429 27.1 27 1 abnormal brainstem morphology 0.000526486366934618 0.00607719182250516 1.22483994424626 0.678571428571429 27.1 27 1 abnormal mitotic spindle morphology 0.000526486366934618 0.00607719182250516 1.22483994424626 0.678571428571429 27.1 27 1 abnormal cell cycle 2.19261256798374e-12 1.73146786122526e-10 1.22427937676606 0.678260869565217 27.1 27 1 abnormal nervous system physiology 2.19261256798374e-12 1.73146786122526e-10 1.22427937676606 0.678260869565217 27.1 27 1 embryonic lethality between implantation and somite formation, complete penetrance 1.27803709266982e-24 3.53235252001798e-22 1.22299807966845 0.677551020408163 27.1 27 1 pericardial effusion 2.73353580284378e-07 8.0948456066356e-06 1.22276041972292 0.67741935483871 27.1 27 1 preaxial polydactyly 0.000277361773229653 0.00355526567901134 1.22276041972292 0.67741935483871 27.1 27 1 abnormal mitochondrial ATP synthesis coupled electron transport 0.000277361773229653 0.00355526567901134 1.22276041972292 0.67741935483871 27.1 27 1 enlarged liver sinusoidal spaces 0.000146671510747801 0.00203824236304556 1.22104787011547 0.676470588235294 27.1 27 1 decreased embryo size 3.15207146968385e-46 2.61359259361286e-43 1.21971509092306 0.675732217573222 27.1 27 1 pale liver 2.31629808559213e-08 8.770554363678e-07 1.21961303125517 0.675675675675676 27.1 27 1 abnormal vocalization 7.78066260672924e-05 0.00120213653628814 1.21961303125517 0.675675675675676 27.1 27 1 abnormal calcium ion homeostasis 7.78066260672924e-05 0.00120213653628814 1.21961303125517 0.675675675675676 27.1 27 1 abnormal cell morphology 4.20230738357448e-12 3.02992452656276e-10 1.21918509685824 0.675438596491228 27.1 27 1 abnormal social investigation 6.76846866233012e-09 2.82967492395734e-07 1.21839341822391 0.675 27.1 27 1 abnormal locomotor behavior 5.8123944452805e-10 2.89166623652705e-08 1.2164314320432 0.673913043478261 27.1 27 1 abnormal allantois morphology 1.17863436809512e-05 0.00023405393499683 1.2164314320432 0.673913043478261 27.1 27 1 abnormal embryonic neuroepithelium morphology 9.74720157763768e-07 2.51255584708536e-05 1.21372524420773 0.672413793103448 27.1 27 1 astrocytosis 4.42785986969758e-08 1.55131005998208e-06 1.21159365789897 0.671232876712329 27.1 27 1 embryonic lethality, complete penetrance 2.21147295834126e-30 7.85862711981984e-28 1.21089604783428 0.670846394984326 27.1 27 1 increased cell proliferation 3.45868205524073e-06 7.87610631024243e-05 1.20335152417177 0.666666666666667 27.1 27 1 impaired limb coordination 3.45868205524073e-06 7.87610631024243e-05 1.20335152417177 0.666666666666667 27.1 27 1 abnormal atrioventricular cushion morphology 0.00101844222529244 0.0100730617710336 1.20335152417177 0.666666666666667 27.1 27 1 abnormal trigeminal nerve morphology 0.00101844222529244 0.0100730617710336 1.20335152417177 0.666666666666667 27.1 27 1 increased brain weight 0.00101844222529244 0.0100730617710336 1.20335152417177 0.666666666666667 27.1 27 1 thick interventricular septum 0.00101844222529244 0.0100730617710336 1.20335152417177 0.666666666666667 27.1 27 1 failure of chorioallantoic fusion 6.45043286787052e-06 0.00013597840473583 1.20335152417177 0.666666666666667 27.1 27 1 abnormal dendritic spine morphology 6.45043286787052e-06 0.00013597840473583 1.20335152417177 0.666666666666667 27.1 27 1 vertebral transformation 1.20476624235003e-05 0.000237845716495689 1.20335152417177 0.666666666666667 27.1 27 1 abnormal optic nerve morphology 4.2246751734749e-05 0.000708828894140599 1.20335152417177 0.666666666666667 27.1 27 1 dextrocardia 0.000282277375519493 0.00355526567901134 1.20335152417177 0.666666666666667 27.1 27 1 increased cardiomyocyte apoptosis 0.000282277375519493 0.00355526567901134 1.20335152417177 0.666666666666667 27.1 27 1 cardiovascular system phenotype 0.000282277375519493 0.00355526567901134 1.20335152417177 0.666666666666667 27.1 27 1 enhanced paired-pulse facilitation 0.000535040104700011 0.00609690566946794 1.20335152417177 0.666666666666667 27.1 27 1 increased stereotypic behavior 0.00194869661679969 0.0172504727198905 1.20335152417177 0.666666666666667 27.1 27 1 hemolytic anemia 0.00194869661679969 0.0172504727198905 1.20335152417177 0.666666666666667 27.1 27 1 complete atrioventricular septal defect 0.00375306252421433 0.0296843975484361 1.20335152417177 0.666666666666667 27.1 27 1 increased muscle cell glucose uptake 0.00375306252421433 0.0296843975484361 1.20335152417177 0.666666666666667 27.1 27 1 abnormal mitral valve morphology 0.00728932285511272 0.0492054019052724 1.20335152417177 0.666666666666667 27.1 27 1 abnormal thymus cortex morphology 0.00728932285511272 0.0492054019052724 1.20335152417177 0.666666666666667 27.1 27 1 abnormal redox activity 0.00728932285511272 0.0492054019052724 1.20335152417177 0.666666666666667 27.1 27 1 absent ureter 0.00728932285511272 0.0492054019052724 1.20335152417177 0.666666666666667 27.1 27 1 absent inner cell mass 0.00728932285511272 0.0492054019052724 1.20335152417177 0.666666666666667 27.1 27 1 darkened coat color 0.00728932285511272 0.0492054019052724 1.20335152417177 0.666666666666667 27.1 27 1 decreased pulmonary respiratory rate 0.00728932285511272 0.0492054019052724 1.20335152417177 0.666666666666667 27.1 27 1 abnormal pregnancy 0.00728932285511272 0.0492054019052724 1.20335152417177 0.666666666666667 27.1 27 1 increased gastrointestinal tumor incidence 0.00728932285511272 0.0492054019052724 1.20335152417177 0.666666666666667 27.1 27 1 abnormal aerobic respiration 0.00728932285511272 0.0492054019052724 1.20335152417177 0.666666666666667 27.1 27 1 abnormal hypoglossal nerve topology 0.00728932285511272 0.0492054019052724 1.20335152417177 0.666666666666667 27.1 27 1 abnormal enteric neuron morphology 0.0143184573779098 0.0836992785047199 1.20335152417177 0.666666666666667 27.1 27 1 audiogenic seizures 0.0143184573779098 0.0836992785047199 1.20335152417177 0.666666666666667 27.1 27 1 abnormal seizure response to electrical stimulation 0.0143184573779098 0.0836992785047199 1.20335152417177 0.666666666666667 27.1 27 1 dilated ureter 0.0143184573779098 0.0836992785047199 1.20335152417177 0.666666666666667 27.1 27 1 abnormal placenta size 0.0143184573779098 0.0836992785047199 1.20335152417177 0.666666666666667 27.1 27 1 immune system phenotype 0.0143184573779098 0.0836992785047199 1.20335152417177 0.666666666666667 27.1 27 1 abnormal adipose tissue distribution 0.028578156811939 0.132287475754227 1.20335152417177 0.666666666666667 27.1 27 1 abnormal mineral level 0.028578156811939 0.132287475754227 1.20335152417177 0.666666666666667 27.1 27 1 impaired embryo implantation 0.028578156811939 0.132287475754227 1.20335152417177 0.666666666666667 27.1 27 1 altered tumor susceptibility 0.028578156811939 0.132287475754227 1.20335152417177 0.666666666666667 27.1 27 1 increased growth rate 0.028578156811939 0.132287475754227 1.20335152417177 0.666666666666667 27.1 27 1 abnormal gastrocnemius morphology 0.028578156811939 0.132287475754227 1.20335152417177 0.666666666666667 27.1 27 1 small intestinal inflammation 0.028578156811939 0.132287475754227 1.20335152417177 0.666666666666667 27.1 27 1 decreased left ventricle systolic pressure 0.028578156811939 0.132287475754227 1.20335152417177 0.666666666666667 27.1 27 1 abnormal fatty acid level 0.028578156811939 0.132287475754227 1.20335152417177 0.666666666666667 27.1 27 1 reduced cerebellar foliation 0.028578156811939 0.132287475754227 1.20335152417177 0.666666666666667 27.1 27 1 increased skeletal muscle glycogen level 0.028578156811939 0.132287475754227 1.20335152417177 0.666666666666667 27.1 27 1 abnormal pulmonary valve cusp morphology 0.028578156811939 0.132287475754227 1.20335152417177 0.666666666666667 27.1 27 1 prenatal growth retardation 0.028578156811939 0.132287475754227 1.20335152417177 0.666666666666667 27.1 27 1 heart hyperplasia 0.0584411111937828 0.21083722131187 1.20335152417177 0.666666666666667 27.1 27 1 abnormal head movements 0.0584411111937828 0.21083722131187 1.20335152417177 0.666666666666667 27.1 27 1 synostosis 0.0584411111937828 0.21083722131187 1.20335152417177 0.666666666666667 27.1 27 1 absent enteric neurons 0.0584411111937828 0.21083722131187 1.20335152417177 0.666666666666667 27.1 27 1 abnormal kindling response 0.0584411111937828 0.21083722131187 1.20335152417177 0.666666666666667 27.1 27 1 abnormal germ cell morphology 0.0584411111937828 0.21083722131187 1.20335152417177 0.666666666666667 27.1 27 1 abnormal posterior semicircular canal morphology 0.0584411111937828 0.21083722131187 1.20335152417177 0.666666666666667 27.1 27 1 genetic imprinting 0.0584411111937828 0.21083722131187 1.20335152417177 0.666666666666667 27.1 27 1 premature bone ossification 0.0584411111937828 0.21083722131187 1.20335152417177 0.666666666666667 27.1 27 1 abnormal bony labyrinth 0.0584411111937828 0.21083722131187 1.20335152417177 0.666666666666667 27.1 27 1 short frontal bone 0.0584411111937828 0.21083722131187 1.20335152417177 0.666666666666667 27.1 27 1 increased neuronal precursor cell number 0.0584411111937828 0.21083722131187 1.20335152417177 0.666666666666667 27.1 27 1 abnormal CNS synapse formation 0.0584411111937828 0.21083722131187 1.20335152417177 0.666666666666667 27.1 27 1 decreased susceptibility to atherosclerosis 0.0584411111937828 0.21083722131187 1.20335152417177 0.666666666666667 27.1 27 1 increased tidal volume 0.0584411111937828 0.21083722131187 1.20335152417177 0.666666666666667 27.1 27 1 eye opacity 0.0584411111937828 0.21083722131187 1.20335152417177 0.666666666666667 27.1 27 1 decreased transitional stage T1 B cell number 0.0584411111937828 0.21083722131187 1.20335152417177 0.666666666666667 27.1 27 1 abnormal telomere morphology 0.0584411111937828 0.21083722131187 1.20335152417177 0.666666666666667 27.1 27 1 decreased effector memory CD4-positive, alpha-beta T cell number 0.0584411111937828 0.21083722131187 1.20335152417177 0.666666666666667 27.1 27 1 abnormal lung lobe morphology 0.0584411111937828 0.21083722131187 1.20335152417177 0.666666666666667 27.1 27 1 abnormal ureteric bud invasion 0.0584411111937828 0.21083722131187 1.20335152417177 0.666666666666667 27.1 27 1 decreased pancreatic beta cell proliferation 0.0584411111937828 0.21083722131187 1.20335152417177 0.666666666666667 27.1 27 1 decreased bone trabecular spacing 0.0584411111937828 0.21083722131187 1.20335152417177 0.666666666666667 27.1 27 1 symmetric azygos veins 0.0584411111937828 0.21083722131187 1.20335152417177 0.666666666666667 27.1 27 1 increased endoplasmic reticulum stress 0.0584411111937828 0.21083722131187 1.20335152417177 0.666666666666667 27.1 27 1 pale yolk sac 1.35180839438715e-08 5.38019740966087e-07 1.19610241860447 0.662650602409639 27.1 27 1 preweaning lethality, incomplete penetrance 1.16301702844864e-36 5.78600971653198e-34 1.19599607475751 0.662591687041565 27.1 27 1 decreased grip strength 3.08352915983828e-20 6.13622302807818e-18 1.19510939044456 0.662100456621005 27.1 27 1 increased circulating free fatty acid level 1.58722085936764e-07 4.99593499413208e-06 1.19487721766351 0.661971830985915 27.1 27 1 abnormal behavior 2.95552093092063e-25 8.64924507725303e-23 1.1946943189619 0.661870503597122 27.1 27 1 pulmonary hypoplasia 2.27949499740788e-05 0.000414947669942308 1.19054991221249 0.659574468085106 27.1 27 1 embryonic lethality, incomplete penetrance 4.26686248349515e-05 0.000708828894140599 1.18967707503345 0.659090909090909 27.1 27 1 embryonic lethality during organogenesis, complete penetrance 1.26207846262259e-48 1.25576807030947e-45 1.18938405112334 0.658928571428571 27.1 27 1 abnormal mammary gland development 8.00266338480318e-05 0.00121381860790841 1.1886765055843 0.658536585365854 27.1 27 1 abnormal cell differentiation 8.00266338480318e-05 0.00121381860790841 1.1886765055843 0.658536585365854 27.1 27 1 abnormal placenta morphology 4.68722711247323e-08 1.59226360196602e-06 1.18811922639744 0.658227848101266 27.1 27 1 abnormal nervous system morphology 4.68722711247323e-08 1.59226360196602e-06 1.18811922639744 0.658227848101266 27.1 27 1 decreased neuron apoptosis 0.000150434157533589 0.00207315771116234 1.18751795148529 0.657894736842105 27.1 27 1 cleft palate 2.68710421221199e-12 2.08011243071895e-10 1.18497974517678 0.656488549618321 27.1 27 1 increased sacral vertebrae number 1.02345596721584e-06 2.58461595781664e-05 1.18454915660658 0.65625 27.1 27 1 failure of primitive streak formation 0.000536056793116749 0.00609690566946794 1.18454915660658 0.65625 27.1 27 1 bradykinesia 0.000536056793116749 0.00609690566946794 1.18454915660658 0.65625 27.1 27 1 abnormal spinal nerve morphology 0.00101723468672106 0.0100730617710336 1.18260408409984 0.655172413793103 27.1 27 1 distended pericardium 1.22496960375164e-05 0.00023825730309568 1.18021014870692 0.653846153846154 27.1 27 1 abnormal placenta vasculature 1.22496960375164e-05 0.00023825730309568 1.18021014870692 0.653846153846154 27.1 27 1 abnormal ureter morphology 0.00193897037691702 0.0172256743306468 1.18021014870692 0.653846153846154 27.1 27 1 increased thymocyte apoptosis 0.00193897037691702 0.0172256743306468 1.18021014870692 0.653846153846154 27.1 27 1 lethality throughout fetal growth and development, incomplete penetrance 5.50723526512145e-16 7.02525524204595e-14 1.17982230442539 0.653631284916201 27.1 27 1 increased circulating LDL cholesterol level 2.28533993093854e-05 0.000414947669942308 1.17879332980091 0.653061224489796 27.1 27 1 lethality throughout fetal growth and development, complete penetrance 8.95713826460732e-17 1.20437196936274e-14 1.17801780787341 0.652631578947368 27.1 27 1 abnormal cell death 4.2700597991178e-05 0.000708828894140599 1.1771917084289 0.652173913043478 27.1 27 1 abnormal myelin sheath morphology 4.2700597991178e-05 0.000708828894140599 1.1771917084289 0.652173913043478 27.1 27 1 abnormal Wolffian duct morphology 0.00371629621616421 0.029512290804023 1.1771917084289 0.652173913043478 27.1 27 1 abnormal hematopoietic stem cell physiology 0.00371629621616421 0.029512290804023 1.1771917084289 0.652173913043478 27.1 27 1 abnormal coat/hair pigmentation 1.93342251079492e-10 1.08076145968592e-08 1.17649099907865 0.651785714285714 27.1 27 1 abnormal axon guidance 7.99213738022406e-05 0.00121381860790841 1.17536660500498 0.651162790697674 27.1 27 1 decreased oxygen consumption 7.99213738022406e-05 0.00121381860790841 1.17536660500498 0.651162790697674 27.1 27 1 prenatal lethality, complete penetrance 1.26750864735453e-23 3.15292776029439e-21 1.17521560723969 0.651079136690647 27.1 27 1 abnormal neural tube closure 4.73678418273308e-08 1.59226360196602e-06 1.17435510190257 0.650602409638554 27.1 27 1 abnormal pericardium morphology 0.00717234478214569 0.0492054019052724 1.17326773606747 0.65 27.1 27 1 abnormal response to tactile stimuli 0.00717234478214569 0.0492054019052724 1.17326773606747 0.65 27.1 27 1 increased hepatocellular carcinoma incidence 6.5652506449505e-06 0.000137604888310568 1.17168437879882 0.649122807017544 27.1 27 1 kidney cysts 2.98886942575157e-07 8.69568736439419e-06 1.17082851000496 0.648648648648649 27.1 27 1 malocclusion 0.000281711278826067 0.00355526567901134 1.17082851000496 0.648648648648649 27.1 27 1 decreased width of hypertrophic chondrocyte zone 0.000281711278826067 0.00355526567901134 1.17082851000496 0.648648648648649 27.1 27 1 abnormal neuronal precursor proliferation 1.2210920991914e-05 0.00023825730309568 1.16992509294477 0.648148148148148 27.1 27 1 abnormal ovary morphology 5.52870580089595e-07 1.50302247865887e-05 1.16945429813876 0.647887323943662 27.1 27 1 abnormal lung development 4.72853580751186e-08 1.59226360196602e-06 1.16795883228436 0.647058823529412 27.1 27 1 pericardial edema 1.02328050843944e-06 2.58461595781664e-05 1.16795883228436 0.647058823529412 27.1 27 1 abnormal inhibitory postsynaptic currents 1.02328050843944e-06 2.58461595781664e-05 1.16795883228436 0.647058823529412 27.1 27 1 abnormal brown adipose tissue morphology 0.000530888127600931 0.00609690566946794 1.16795883228436 0.647058823529412 27.1 27 1 abnormal direction of heart looping 0.000530888127600931 0.00609690566946794 1.16795883228436 0.647058823529412 27.1 27 1 abnormal adipose tissue morphology 0.0139676036535086 0.0829222293272141 1.16795883228436 0.647058823529412 27.1 27 1 abnormal electroretinogram waveform feature 0.0139676036535086 0.0829222293272141 1.16795883228436 0.647058823529412 27.1 27 1 abnormal cell cytoskeleton morphology 0.0139676036535086 0.0829222293272141 1.16795883228436 0.647058823529412 27.1 27 1 abnormal extraembryonic tissue morphology 2.21993582452446e-09 9.94971236667493e-08 1.16795883228436 0.647058823529412 27.1 27 1 increased lung adenocarcinoma incidence 2.27375103361913e-05 0.000414947669942308 1.16795883228436 0.647058823529412 27.1 27 1 abnormal trophoblast layer morphology 2.27375103361913e-05 0.000414947669942308 1.16795883228436 0.647058823529412 27.1 27 1 curly tail 4.23929449192514e-05 0.000708828894140599 1.1657467890414 0.645833333333333 27.1 27 1 osteopetrosis 0.00100354616191884 0.0100296137821439 1.16453373306945 0.645161290322581 27.1 27 1 abnormal cranial ganglia morphology 0.00100354616191884 0.0100296137821439 1.16453373306945 0.645161290322581 27.1 27 1 abnormal capillary morphology 0.00100354616191884 0.0100296137821439 1.16453373306945 0.645161290322581 27.1 27 1 small placenta 7.91533382309996e-05 0.00121381860790841 1.16323980669937 0.644444444444444 27.1 27 1 seminiferous tubule degeneration 5.49208498339225e-07 1.50127048309761e-05 1.16214085553575 0.643835616438356 27.1 27 1 increased insulin sensitivity 2.71773483410516e-12 2.08011243071895e-10 1.16127629605387 0.643356643356643 27.1 27 1 domed cranium 1.01500087678901e-06 2.58461595781664e-05 1.16037468402277 0.642857142857143 27.1 27 1 abnormal reproductive system morphology 0.000148030421651941 0.00204569818810669 1.16037468402277 0.642857142857143 27.1 27 1 spina bifida 0.000148030421651941 0.00204569818810669 1.16037468402277 0.642857142857143 27.1 27 1 rib bifurcation 0.00190396277033653 0.0171287789917255 1.16037468402277 0.642857142857143 27.1 27 1 abnormal somite shape 0.00190396277033653 0.0171287789917255 1.16037468402277 0.642857142857143 27.1 27 1 straub tail 0.00190396277033653 0.0171287789917255 1.16037468402277 0.642857142857143 27.1 27 1 premature aging 0.00190396277033653 0.0171287789917255 1.16037468402277 0.642857142857143 27.1 27 1 extended life span 0.0275333380801492 0.131547515031184 1.16037468402277 0.642857142857143 27.1 27 1 abnormal fluid regulation 0.0275333380801492 0.131547515031184 1.16037468402277 0.642857142857143 27.1 27 1 abnormal imprinting 0.0275333380801492 0.131547515031184 1.16037468402277 0.642857142857143 27.1 27 1 enlarged stomach 0.0275333380801492 0.131547515031184 1.16037468402277 0.642857142857143 27.1 27 1 abnormal maternal decidual layer morphology 0.0275333380801492 0.131547515031184 1.16037468402277 0.642857142857143 27.1 27 1 increased pulmonary respiratory rate 0.0275333380801492 0.131547515031184 1.16037468402277 0.642857142857143 27.1 27 1 sternebra fusion 0.0275333380801492 0.131547515031184 1.16037468402277 0.642857142857143 27.1 27 1 increased circulating alkaline phosphatase level 1.29683196900856e-13 1.26504687172894e-11 1.15878294920244 0.641975308641975 27.1 27 1 increased exploration in new environment 1.59669078204422e-07 4.99593499413208e-06 1.15878294920244 0.641975308641975 27.1 27 1 abnormal muscle physiology 4.6542516636598e-08 1.59226360196602e-06 1.15602871142344 0.640449438202247 27.1 27 1 increased circulating chloride level 4.17948858135245e-05 0.000707243390892124 1.1552174632049 0.64 27.1 27 1 abnormal egg cylinder morphology 0.00362821170515556 0.0293025214823846 1.1552174632049 0.64 27.1 27 1 abnormal preimplantation embryo development 0.00362821170515556 0.0293025214823846 1.1552174632049 0.64 27.1 27 1 abnormal hepatocyte morphology 1.18157758798839e-09 5.54561179268135e-08 1.15456700292156 0.63963963963964 27.1 27 1 abnormal heart development 4.30839821913499e-13 3.89714202549029e-11 1.15384655640521 0.639240506329114 27.1 27 1 prenatal lethality, incomplete penetrance 1.20197493727616e-23 3.14727648049941e-21 1.15189241294074 0.638157894736842 27.1 27 1 increased mean corpuscular hemoglobin 1.34024567316805e-08 5.3771953419444e-07 1.1486537276185 0.636363636363636 27.1 27 1 abnormal locomotor coordination 0.000980170773911942 0.0100296137821439 1.1486537276185 0.636363636363636 27.1 27 1 aphakia 0.0069514348220915 0.0485102459394288 1.1486537276185 0.636363636363636 27.1 27 1 abnormal retinal outer plexiform layer morphology 0.0069514348220915 0.0485102459394288 1.1486537276185 0.636363636363636 27.1 27 1 abnormal blood-brain barrier function 0.0069514348220915 0.0485102459394288 1.1486537276185 0.636363636363636 27.1 27 1 abnormal cerebral cortex pyramidal cell morphology 0.0069514348220915 0.0485102459394288 1.1486537276185 0.636363636363636 27.1 27 1 increased circulating creatine kinase level 0.0069514348220915 0.0485102459394288 1.1486537276185 0.636363636363636 27.1 27 1 increased adenoma incidence 0.0069514348220915 0.0485102459394288 1.1486537276185 0.636363636363636 27.1 27 1 embryonic lethality before implantation, incomplete penetrance 0.0069514348220915 0.0485102459394288 1.1486537276185 0.636363636363636 27.1 27 1 abnormal ear position 0.0552209368583632 0.21083722131187 1.1486537276185 0.636363636363636 27.1 27 1 premature suture closure 0.0552209368583632 0.21083722131187 1.1486537276185 0.636363636363636 27.1 27 1 abnormal sphenoid bone morphology 0.0552209368583632 0.21083722131187 1.1486537276185 0.636363636363636 27.1 27 1 abnormal thrombopoiesis 0.0552209368583632 0.21083722131187 1.1486537276185 0.636363636363636 27.1 27 1 abnormal glossopharyngeal ganglion morphology 0.0552209368583632 0.21083722131187 1.1486537276185 0.636363636363636 27.1 27 1 abnormal eye distance/ position 0.0552209368583632 0.21083722131187 1.1486537276185 0.636363636363636 27.1 27 1 social withdrawal 0.0552209368583632 0.21083722131187 1.1486537276185 0.636363636363636 27.1 27 1 abnormal hemoglobin 0.0552209368583632 0.21083722131187 1.1486537276185 0.636363636363636 27.1 27 1 impaired myelopoiesis 0.0552209368583632 0.21083722131187 1.1486537276185 0.636363636363636 27.1 27 1 failure of somite differentiation 0.0552209368583632 0.21083722131187 1.1486537276185 0.636363636363636 27.1 27 1 abnormal bronchiole morphology 0.0552209368583632 0.21083722131187 1.1486537276185 0.636363636363636 27.1 27 1 abnormal vestibular ganglion morphology 0.0552209368583632 0.21083722131187 1.1486537276185 0.636363636363636 27.1 27 1 fused joints 0.0552209368583632 0.21083722131187 1.1486537276185 0.636363636363636 27.1 27 1 abnormal nerve fiber response 0.0552209368583632 0.21083722131187 1.1486537276185 0.636363636363636 27.1 27 1 pharyngeal arch hypoplasia 0.0552209368583632 0.21083722131187 1.1486537276185 0.636363636363636 27.1 27 1 abnormal dorsal-ventral polarity of the somites 0.0552209368583632 0.21083722131187 1.1486537276185 0.636363636363636 27.1 27 1 increased glycogen level 0.0552209368583632 0.21083722131187 1.1486537276185 0.636363636363636 27.1 27 1 increased number of Howell-Jolly bodies 0.0552209368583632 0.21083722131187 1.1486537276185 0.636363636363636 27.1 27 1 common atrioventricular valve 0.0552209368583632 0.21083722131187 1.1486537276185 0.636363636363636 27.1 27 1 abnormal pulmonary alveolar sac morphology 0.0552209368583632 0.21083722131187 1.1486537276185 0.636363636363636 27.1 27 1 decreased core body temperature 0.0552209368583632 0.21083722131187 1.1486537276185 0.636363636363636 27.1 27 1 hypolactation 0.0552209368583632 0.21083722131187 1.1486537276185 0.636363636363636 27.1 27 1 abnormal testis morphology 1.1481258340378e-09 5.4399295469886e-08 1.14579992953746 0.634782608695652 27.1 27 1 hypoactivity 3.54283063240602e-28 1.10159889976375e-25 1.1443011178132 0.63395225464191 27.1 27 1 reduced long term potentiation 2.10248953344718e-09 9.5089867535452e-08 1.1442583689669 0.633928571428571 27.1 27 1 muscular ventricular septal defect 1.16638338547836e-05 0.000233042463564451 1.14318394796318 0.633333333333333 27.1 27 1 delayed eyelid opening 0.0018501162374847 0.0168568333535414 1.14318394796318 0.633333333333333 27.1 27 1 abnormal optic cup morphology 0.0018501162374847 0.0168568333535414 1.14318394796318 0.633333333333333 27.1 27 1 embryonic growth arrest 1.32277946150562e-17 1.88023652028298e-15 1.14292120745572 0.633187772925764 27.1 27 1 increased anxiety-related response 2.90665486454487e-11 1.80757599388884e-09 1.14275108770268 0.633093525179856 27.1 27 1 decreased startle reflex 1.12724165170846e-09 5.39233386274e-08 1.14164118959885 0.632478632478632 27.1 27 1 abnormal facial morphology 2.15699867988359e-05 0.000397446978978551 1.14001723342588 0.631578947368421 27.1 27 1 persistence of hyaloid vascular system 0.000506757772470314 0.00596009436888845 1.14001723342588 0.631578947368421 27.1 27 1 incomplete somite formation 0.000506757772470314 0.00596009436888845 1.14001723342588 0.631578947368421 27.1 27 1 impaired branching involved in ureteric bud morphogenesis 0.000506757772470314 0.00596009436888845 1.14001723342588 0.631578947368421 27.1 27 1 enlarged adrenal glands 0.0134091246768144 0.0807631903960675 1.14001723342588 0.631578947368421 27.1 27 1 maternal imprinting 0.0134091246768144 0.0807631903960675 1.14001723342588 0.631578947368421 27.1 27 1 abnormal cochlear inner hair cell morphology 0.0134091246768144 0.0807631903960675 1.14001723342588 0.631578947368421 27.1 27 1 absent amnion 0.0134091246768144 0.0807631903960675 1.14001723342588 0.631578947368421 27.1 27 1 decreased liver regeneration 0.0134091246768144 0.0807631903960675 1.14001723342588 0.631578947368421 27.1 27 1 decreased circulating magnesium level 0.0134091246768144 0.0807631903960675 1.14001723342588 0.631578947368421 27.1 27 1 right-sided stomach 0.0134091246768144 0.0807631903960675 1.14001723342588 0.631578947368421 27.1 27 1 abnormal liver physiology 2.36232017031729e-08 8.770554363678e-07 1.13716719034232 0.63 27.1 27 1 abnormal cell adhesion 3.99112855054804e-05 0.00067767455764425 1.13649866171778 0.62962962962963 27.1 27 1 abnormal eye muscle morphology 0.0035038682346788 0.0286235541338703 1.13649866171778 0.62962962962963 27.1 27 1 decreased circulating fructosamine level 0.0035038682346788 0.0286235541338703 1.13649866171778 0.62962962962963 27.1 27 1 abnormal motor capabilities/coordination/movement 1.73326168700359e-10 9.91146769292284e-09 1.13497927848019 0.628787878787879 27.1 27 1 abnormal liver development 0.000949487758131912 0.00982058544013776 1.13458857993338 0.628571428571429 27.1 27 1 increased circulating serum albumin level 0.000949487758131912 0.00982058544013776 1.13458857993338 0.628571428571429 27.1 27 1 decreased triglyceride level 0.000949487758131912 0.00982058544013776 1.13458857993338 0.628571428571429 27.1 27 1 decreased glycogen level 0.000949487758131912 0.00982058544013776 1.13458857993338 0.628571428571429 27.1 27 1 decreased body weight 2.63760150292371e-87 1.31220674770454e-83 1.13433863385174 0.62843295638126 27.1 27 1 increased circulating alanine transaminase level 9.40678166055892e-07 2.44806343246167e-05 1.13392739777724 0.628205128205128 27.1 27 1 edema 3.81220992400364e-13 3.51217488368854e-11 1.1333892262548 0.627906976744186 27.1 27 1 abnormal double-strand DNA break repair 0.00026296443989831 0.00340108021886236 1.1333892262548 0.627906976744186 27.1 27 1 abnormal gluconeogenesis 7.38915181964015e-05 0.00115600724222358 1.13256614039696 0.627450980392157 27.1 27 1 small lung 7.38915181964015e-05 0.00115600724222358 1.13256614039696 0.627450980392157 27.1 27 1 embryonic lethality during organogenesis, incomplete penetrance 7.18814386827758e-17 9.9336154846336e-15 1.13010404009175 0.626086956521739 27.1 27 1 abnormal embryonic tissue morphology 2.65832545609276e-11 1.67407204355209e-09 1.12967694105921 0.625850340136054 27.1 27 1 abnormal embryo development 1.64781343654017e-10 9.53240912417135e-09 1.12814205391103 0.625 27.1 27 1 enhanced long term potentiation 3.8708788957351e-05 0.000659507620078154 1.12814205391103 0.625 27.1 27 1 abnormal vertebral body morphology 0.00178269510992233 0.0163632992100804 1.12814205391103 0.625 27.1 27 1 abnormal heart atrium morphology 0.00178269510992233 0.0163632992100804 1.12814205391103 0.625 27.1 27 1 increased fatty acid level 0.00178269510992233 0.0163632992100804 1.12814205391103 0.625 27.1 27 1 apnea 0.00666229554843839 0.0471478241159047 1.12814205391103 0.625 27.1 27 1 abnormal tumor morphology 0.00666229554843839 0.0471478241159047 1.12814205391103 0.625 27.1 27 1 abnormal osteoblast morphology 0.00666229554843839 0.0471478241159047 1.12814205391103 0.625 27.1 27 1 absent mandible 0.0260927527925905 0.129165617057849 1.12814205391103 0.625 27.1 27 1 failure of tooth eruption 0.0260927527925905 0.129165617057849 1.12814205391103 0.625 27.1 27 1 vasculature congestion 0.0260927527925905 0.129165617057849 1.12814205391103 0.625 27.1 27 1 disorganized yolk sac vascular plexus 0.0260927527925905 0.129165617057849 1.12814205391103 0.625 27.1 27 1 intraventricular hemorrhage 0.0260927527925905 0.129165617057849 1.12814205391103 0.625 27.1 27 1 paternal imprinting 0.0260927527925905 0.129165617057849 1.12814205391103 0.625 27.1 27 1 impaired muscle relaxation 0.0260927527925905 0.129165617057849 1.12814205391103 0.625 27.1 27 1 abnormal level of surface class II molecules 0.0260927527925905 0.129165617057849 1.12814205391103 0.625 27.1 27 1 loose skin 0.0260927527925905 0.129165617057849 1.12814205391103 0.625 27.1 27 1 decreased creatinine clearance 0.0260927527925905 0.129165617057849 1.12814205391103 0.625 27.1 27 1 kidney degeneration 0.0260927527925905 0.129165617057849 1.12814205391103 0.625 27.1 27 1 decreased fibroblast apoptosis 0.0260927527925905 0.129165617057849 1.12814205391103 0.625 27.1 27 1 abnormal exoccipital bone morphology 0.113734307266739 0.344555928388158 1.12814205391103 0.625 27.1 27 1 abnormal bone marrow development 0.113734307266739 0.344555928388158 1.12814205391103 0.625 27.1 27 1 schistocytosis 0.113734307266739 0.344555928388158 1.12814205391103 0.625 27.1 27 1 abnormal cecum morphology 0.113734307266739 0.344555928388158 1.12814205391103 0.625 27.1 27 1 dermal cysts 0.113734307266739 0.344555928388158 1.12814205391103 0.625 27.1 27 1 abnormal pupil morphology 0.113734307266739 0.344555928388158 1.12814205391103 0.625 27.1 27 1 absent eyelids 0.113734307266739 0.344555928388158 1.12814205391103 0.625 27.1 27 1 abnormal atrial thrombosis 0.113734307266739 0.344555928388158 1.12814205391103 0.625 27.1 27 1 preneoplasia 0.113734307266739 0.344555928388158 1.12814205391103 0.625 27.1 27 1 abnormal pulmonary circulation 0.113734307266739 0.344555928388158 1.12814205391103 0.625 27.1 27 1 short ureter 0.113734307266739 0.344555928388158 1.12814205391103 0.625 27.1 27 1 hypospadia 0.113734307266739 0.344555928388158 1.12814205391103 0.625 27.1 27 1 early eyelid opening 0.113734307266739 0.344555928388158 1.12814205391103 0.625 27.1 27 1 abnormal platelet shape 0.113734307266739 0.344555928388158 1.12814205391103 0.625 27.1 27 1 binucleate 0.113734307266739 0.344555928388158 1.12814205391103 0.625 27.1 27 1 abnormal extraembryonic tissue physiology 0.113734307266739 0.344555928388158 1.12814205391103 0.625 27.1 27 1 abnormal lateral ganglionic eminence morphology 0.113734307266739 0.344555928388158 1.12814205391103 0.625 27.1 27 1 small frontal bone 0.113734307266739 0.344555928388158 1.12814205391103 0.625 27.1 27 1 abnormal NK cell morphology 0.113734307266739 0.344555928388158 1.12814205391103 0.625 27.1 27 1 Sertoli cell hypoplasia 0.113734307266739 0.344555928388158 1.12814205391103 0.625 27.1 27 1 ocular hypertension 0.113734307266739 0.344555928388158 1.12814205391103 0.625 27.1 27 1 abnormal epidermal lamellar body morphology 0.113734307266739 0.344555928388158 1.12814205391103 0.625 27.1 27 1 enlarged inguinal lymph nodes 0.113734307266739 0.344555928388158 1.12814205391103 0.625 27.1 27 1 abnormal meiotic spindle morphology 0.113734307266739 0.344555928388158 1.12814205391103 0.625 27.1 27 1 abnormal base-excision repair 0.113734307266739 0.344555928388158 1.12814205391103 0.625 27.1 27 1 abnormal brain ependyma morphology 0.113734307266739 0.344555928388158 1.12814205391103 0.625 27.1 27 1 decreased quadriceps weight 0.113734307266739 0.344555928388158 1.12814205391103 0.625 27.1 27 1 ostium secundum atrial septal defect 0.113734307266739 0.344555928388158 1.12814205391103 0.625 27.1 27 1 increased heart right ventricle size 0.113734307266739 0.344555928388158 1.12814205391103 0.625 27.1 27 1 decreased alveolar lamellar body number 0.113734307266739 0.344555928388158 1.12814205391103 0.625 27.1 27 1 absent ureteric bud 0.113734307266739 0.344555928388158 1.12814205391103 0.625 27.1 27 1 abnormal macrophage activation involved in immune response 0.113734307266739 0.344555928388158 1.12814205391103 0.625 27.1 27 1 abnormal heart echocardiography feature 0.113734307266739 0.344555928388158 1.12814205391103 0.625 27.1 27 1 increased testis apoptosis 0.113734307266739 0.344555928388158 1.12814205391103 0.625 27.1 27 1 abnormal umbilical vein topology 0.113734307266739 0.344555928388158 1.12814205391103 0.625 27.1 27 1 decreased body length 1.51721523605537e-19 2.90313299975979e-17 1.12649513120459 0.624087591240876 27.1 27 1 decreased spleen weight 5.81773055377876e-06 0.000124693223470655 1.12487207694317 0.623188405797101 27.1 27 1 decreased birth body size 6.36494921506825e-09 2.70646344828757e-07 1.12418366073941 0.62280701754386 27.1 27 1 oxidative stress 2.56955956692705e-07 7.71168796380419e-06 1.12312808922698 0.622222222222222 27.1 27 1 lethality at weaning, complete penetrance 0.000253754254812169 0.00331969821445959 1.12312808922698 0.622222222222222 27.1 27 1 increased circulating phosphate level 0.000913485823612952 0.00953010322360193 1.12204398875475 0.621621621621622 27.1 27 1 abnormal breathing pattern 0.000913485823612952 0.00953010322360193 1.12204398875475 0.621621621621622 27.1 27 1 abnormal respiratory electron transport chain 0.000913485823612952 0.00953010322360193 1.12204398875475 0.621621621621622 27.1 27 1 abnormal craniofacial morphology 3.97058340498972e-08 1.41097517427313e-06 1.12157035262611 0.621359223300971 27.1 27 1 abnormal myocardium layer morphology 1.62059153638018e-06 3.97164674556227e-05 1.11957388641297 0.620253164556962 27.1 27 1 abnormal skeletal muscle fiber morphology 5.62065366041899e-06 0.000121050874288244 1.11860845908925 0.619718309859155 27.1 27 1 decreased liver weight 5.62065366041899e-06 0.000121050874288244 1.11860845908925 0.619718309859155 27.1 27 1 abnormal pancreas morphology 0.000470718058892865 0.00562938063219231 1.11739784387378 0.619047619047619 27.1 27 1 reduced fertility 2.7333541570136e-10 1.46219751947771e-08 1.11677947207308 0.618705035971223 27.1 27 1 abnormal joint morphology 6.87905132268668e-05 0.0010899133863174 1.11583504968655 0.618181818181818 27.1 27 1 decreased rib number 4.53070151425766e-07 1.27345988889445e-05 1.1154663004963 0.617977528089888 27.1 27 1 premature death 3.79546986987903e-56 5.53535595420696e-53 1.115301412647 0.617886178861789 27.1 27 1 infertility 3.70716869280854e-08 1.32684634868507e-06 1.11338131675705 0.616822429906542 27.1 27 1 azoospermia 2.2065902982139e-11 1.40740855559156e-09 1.11253254121541 0.616352201257862 27.1 27 1 increased oxygen consumption 8.25518128259549e-07 2.17299084025992e-05 1.11240053687971 0.616279069767442 27.1 27 1 increased embryonic tissue cell apoptosis 2.85105073221858e-06 6.69055537395634e-05 1.1107860223124 0.615384615384615 27.1 27 1 decreased circulating glycerol level 0.00633099783033722 0.0459806046801864 1.1107860223124 0.615384615384615 27.1 27 1 decreased bone resorption 0.00633099783033722 0.0459806046801864 1.1107860223124 0.615384615384615 27.1 27 1 absent teeth 0.0513687642019694 0.202503646517272 1.1107860223124 0.615384615384615 27.1 27 1 small trigeminal ganglion 0.0513687642019694 0.202503646517272 1.1107860223124 0.615384615384615 27.1 27 1 abnormal coping response 0.0513687642019694 0.202503646517272 1.1107860223124 0.615384615384615 27.1 27 1 abnormal soleus morphology 0.0513687642019694 0.202503646517272 1.1107860223124 0.615384615384615 27.1 27 1 tracheoesophageal fistula 0.0513687642019694 0.202503646517272 1.1107860223124 0.615384615384615 27.1 27 1 abnormal afterhyperpolarization 0.0513687642019694 0.202503646517272 1.1107860223124 0.615384615384615 27.1 27 1 muscle fatigue 0.0513687642019694 0.202503646517272 1.1107860223124 0.615384615384615 27.1 27 1 hyperalgesia 0.0513687642019694 0.202503646517272 1.1107860223124 0.615384615384615 27.1 27 1 orthokeratosis 0.0513687642019694 0.202503646517272 1.1107860223124 0.615384615384615 27.1 27 1 empty decidua capsularis 0.0513687642019694 0.202503646517272 1.1107860223124 0.615384615384615 27.1 27 1 decreased cardiac stroke volume 0.0513687642019694 0.202503646517272 1.1107860223124 0.615384615384615 27.1 27 1 retinal degeneration 2.3087948591524e-07 7.04678185538846e-06 1.10933968634585 0.614583333333333 27.1 27 1 abnormal retina morphology 2.35764819419267e-14 2.54984777524099e-12 1.10880247584398 0.614285714285714 27.1 27 1 muscular atrophy 0.000450139169068277 0.00539624666533657 1.10763038020356 0.613636363636364 27.1 27 1 increased tumor incidence 5.34056266197864e-09 2.33064028450384e-07 1.10630704641598 0.612903225806452 27.1 27 1 increased lung adenoma incidence 0.00319051885713062 0.0264547188570414 1.10630704641598 0.612903225806452 27.1 27 1 pale kidney 0.00319051885713062 0.0264547188570414 1.10630704641598 0.612903225806452 27.1 27 1 absent kidney 0.000232954263877363 0.00307413120103416 1.10511874668836 0.612244897959184 27.1 27 1 increased T cell derived lymphoma incidence 0.000232954263877363 0.00307413120103416 1.10511874668836 0.612244897959184 27.1 27 1 decreased white adipose tissue amount 1.8053262556266e-05 0.00034020826218721 1.10456893636662 0.611940298507463 27.1 27 1 abnormal chondrocyte morphology 0.000121010650642977 0.00173996528019887 1.10307223049079 0.611111111111111 27.1 27 1 abnormal apoptosis 0.000121010650642977 0.00173996528019887 1.10307223049079 0.611111111111111 27.1 27 1 thin ventricular wall 7.61249600292009e-07 2.02524960505494e-05 1.10307223049079 0.611111111111111 27.1 27 1 abnormal forebrain development 9.47242996188309e-06 0.000191566418944587 1.10307223049079 0.611111111111111 27.1 27 1 heart right ventricle hypertrophy 0.00162320106770836 0.0151793708869344 1.10307223049079 0.611111111111111 27.1 27 1 lowered ear position 0.0244620449081308 0.123803330028434 1.10307223049079 0.611111111111111 27.1 27 1 abnormal megakaryocyte differentiation 0.0244620449081308 0.123803330028434 1.10307223049079 0.611111111111111 27.1 27 1 underdeveloped hair follicles 0.0244620449081308 0.123803330028434 1.10307223049079 0.611111111111111 27.1 27 1 eye inflammation 0.0244620449081308 0.123803330028434 1.10307223049079 0.611111111111111 27.1 27 1 abnormal thymus medulla morphology 0.0244620449081308 0.123803330028434 1.10307223049079 0.611111111111111 27.1 27 1 abnormal metacarpal bone morphology 0.0244620449081308 0.123803330028434 1.10307223049079 0.611111111111111 27.1 27 1 decreased cellular sensitivity to gamma-irradiation 0.0244620449081308 0.123803330028434 1.10307223049079 0.611111111111111 27.1 27 1 long tibia 0.0244620449081308 0.123803330028434 1.10307223049079 0.611111111111111 27.1 27 1 abnormal neutrophil morphology 0.0244620449081308 0.123803330028434 1.10307223049079 0.611111111111111 27.1 27 1 abnormal anterior eye segment morphology 0.0244620449081308 0.123803330028434 1.10307223049079 0.611111111111111 27.1 27 1 small thoracic cage 0.0244620449081308 0.123803330028434 1.10307223049079 0.611111111111111 27.1 27 1 atrioventricular block 0.0244620449081308 0.123803330028434 1.10307223049079 0.611111111111111 27.1 27 1 decreased fluid intake 0.0244620449081308 0.123803330028434 1.10307223049079 0.611111111111111 27.1 27 1 enlarged liver 2.12598181176191e-07 6.52886389723178e-06 1.10106664461717 0.61 27.1 27 1 decreased anxiety-related response 9.26617549263875e-09 3.80985314676676e-07 1.10062639405954 0.609756097560976 27.1 27 1 increased circulating HDL cholesterol level 1.12488642523723e-07 3.61052255842271e-06 1.10020710781419 0.60952380952381 27.1 27 1 hydroencephaly 3.15569393717454e-08 1.15438068657671e-06 1.09871226120031 0.608695652173913 27.1 27 1 abnormal vitelline vasculature morphology 3.15569393717454e-08 1.15438068657671e-06 1.09871226120031 0.608695652173913 27.1 27 1 abnormal sternum morphology 1.72507952216272e-05 0.000326322076911009 1.09871226120031 0.608695652173913 27.1 27 1 fragile skeleton 0.011983872653534 0.074805227667919 1.09871226120031 0.608695652173913 27.1 27 1 abnormal nasal cavity morphology 0.011983872653534 0.074805227667919 1.09871226120031 0.608695652173913 27.1 27 1 abnormal chondrocyte physiology 0.011983872653534 0.074805227667919 1.09871226120031 0.608695652173913 27.1 27 1 abnormal vertebral artery topology 0.011983872653534 0.074805227667919 1.09871226120031 0.608695652173913 27.1 27 1 abnormal myocardial fiber morphology 3.84798349282389e-07 1.09392673581708e-05 1.09790319473403 0.608247422680412 27.1 27 1 decreased total body fat amount 5.97630213125776e-21 1.23883762929197e-18 1.09706748236618 0.607784431137725 27.1 27 1 decreased exploration in new environment 2.50320500110693e-06 5.95858606722822e-05 1.09590942379929 0.607142857142857 27.1 27 1 abnormal retinal inner nuclear layer morphology 0.00597644940684416 0.0435327024876277 1.09590942379929 0.607142857142857 27.1 27 1 enhanced coordination 0.00597644940684416 0.0435327024876277 1.09590942379929 0.607142857142857 27.1 27 1 perinatal lethality, incomplete penetrance 1.6984170775759e-14 1.87769443576446e-12 1.09419795671371 0.606194690265487 27.1 27 1 single kidney 0.00301734793455372 0.0251025183518474 1.09395593106524 0.606060606060606 27.1 27 1 increased osteoblast cell number 0.00301734793455372 0.0251025183518474 1.09395593106524 0.606060606060606 27.1 27 1 myeloid hyperplasia 0.00301734793455372 0.0251025183518474 1.09395593106524 0.606060606060606 27.1 27 1 cachexia 1.94265691616919e-07 6.00293053288306e-06 1.09342999071377 0.605769230769231 27.1 27 1 decreased total retina thickness 0.00153713550203169 0.0147630291942232 1.09251651536647 0.605263157894737 27.1 27 1 decreased heart weight 4.53374951598062e-06 9.93630125198395e-05 1.09193008674845 0.604938271604938 27.1 27 1 kidney failure 0.000788458887943361 0.00841756001613353 1.09141184750462 0.604651162790698 27.1 27 1 increased thermal nociceptive threshold 1.25755295549976e-06 3.14388238874941e-05 1.09095055762825 0.604395604395604 27.1 27 1 hemorrhage 8.26007674549816e-15 9.55671669973334e-13 1.09069733893015 0.604255319148936 27.1 27 1 thymus atrophy 0.000406623828091936 0.00493403303599362 1.09053731878066 0.604166666666667 27.1 27 1 neonatal lethality, incomplete penetrance 3.53705360434903e-16 4.63074781095695e-14 1.08995878439404 0.603846153846154 27.1 27 1 abnormal spermatogenesis 7.73034365496781e-12 5.34145273381456e-10 1.08890233029673 0.603260869565217 27.1 27 1 decreased susceptibility to hepatic steatosis 5.70858365975073e-05 0.000928111232263394 1.08874661710779 0.603174603174603 27.1 27 1 decreased mean corpuscular hemoglobin 2.98395843210158e-05 0.000524565130731637 1.0883252755377 0.602941176470588 27.1 27 1 short tail 4.31256465109489e-06 9.53555961742093e-05 1.08736583509497 0.602409638554217 27.1 27 1 decreased circulating cholesterol level 1.31942932022284e-11 8.75221449081151e-10 1.08498907917126 0.601092896174863 27.1 27 1 abnormal bone structure 3.7350768667737e-12 2.8064902110211e-10 1.08488686635175 0.601036269430052 27.1 27 1 abnormal retinal pigment epithelium morphology 7.78574277934604e-06 0.000160722283515546 1.08301637175459 0.6 27.1 27 1 impaired fertilization 2.82953281836608e-05 0.000500958212504316 1.08301637175459 0.6 27.1 27 1 abnormal action potential 2.82953281836608e-05 0.000500958212504316 1.08301637175459 0.6 27.1 27 1 intracranial hemorrhage 0.000103701589091344 0.00152187435318418 1.08301637175459 0.6 27.1 27 1 increased body length 0.000384497941102737 0.00469994412035901 1.08301637175459 0.6 27.1 27 1 decreased oocyte number 0.000384497941102737 0.00469994412035901 1.08301637175459 0.6 27.1 27 1 abnormal dermal layer morphology 0.00284060598460721 0.0238716465767245 1.08301637175459 0.6 27.1 27 1 increased carcinoma incidence 0.00284060598460721 0.0238716465767245 1.08301637175459 0.6 27.1 27 1 abnormal artery morphology 0.00284060598460721 0.0238716465767245 1.08301637175459 0.6 27.1 27 1 abnormal microglial cell physiology 0.00561225654804114 0.0414873348090708 1.08301637175459 0.6 27.1 27 1 abnormal cellular respiration 0.00561225654804114 0.0414873348090708 1.08301637175459 0.6 27.1 27 1 spontaneous skin ulceration 0.0112134213133626 0.0707056667097326 1.08301637175459 0.6 27.1 27 1 abnormal cochlear outer hair cell morphology 0.0112134213133626 0.0707056667097326 1.08301637175459 0.6 27.1 27 1 abnormal energy expenditure 0.0112134213133626 0.0707056667097326 1.08301637175459 0.6 27.1 27 1 increased liver glycogen level 0.0112134213133626 0.0707056667097326 1.08301637175459 0.6 27.1 27 1 abnormal basioccipital bone morphology 0.0227642945188175 0.120097948283263 1.08301637175459 0.6 27.1 27 1 abnormal vascular regression 0.0227642945188175 0.120097948283263 1.08301637175459 0.6 27.1 27 1 small gonad 0.0227642945188175 0.120097948283263 1.08301637175459 0.6 27.1 27 1 abnormal hearing physiology 0.0227642945188175 0.120097948283263 1.08301637175459 0.6 27.1 27 1 abnormal lens epithelium morphology 0.0227642945188175 0.120097948283263 1.08301637175459 0.6 27.1 27 1 abnormal postnatal subventricular zone morphology 0.0227642945188175 0.120097948283263 1.08301637175459 0.6 27.1 27 1 enhanced behavioral response to xenobiotic 0.0227642945188175 0.120097948283263 1.08301637175459 0.6 27.1 27 1 absent incisors 0.0473556591335084 0.190764699748344 1.08301637175459 0.6 27.1 27 1 macrocytosis 0.0473556591335084 0.190764699748344 1.08301637175459 0.6 27.1 27 1 interdigital webbing 0.0473556591335084 0.190764699748344 1.08301637175459 0.6 27.1 27 1 abnormal prostate gland morphology 0.0473556591335084 0.190764699748344 1.08301637175459 0.6 27.1 27 1 abnormal pericyte morphology 0.0473556591335084 0.190764699748344 1.08301637175459 0.6 27.1 27 1 decreased aggression towards males 0.0473556591335084 0.190764699748344 1.08301637175459 0.6 27.1 27 1 abnormal trophectoderm morphology 0.0473556591335084 0.190764699748344 1.08301637175459 0.6 27.1 27 1 abnormal olfactory nerve morphology 0.0473556591335084 0.190764699748344 1.08301637175459 0.6 27.1 27 1 abnormal Muller cell morphology 0.0473556591335084 0.190764699748344 1.08301637175459 0.6 27.1 27 1 absent chorion 0.0473556591335084 0.190764699748344 1.08301637175459 0.6 27.1 27 1 bicuspid aortic valve 0.0473556591335084 0.190764699748344 1.08301637175459 0.6 27.1 27 1 abnormal coronary vessel morphology 0.0473556591335084 0.190764699748344 1.08301637175459 0.6 27.1 27 1 herniated liver 0.0473556591335084 0.190764699748344 1.08301637175459 0.6 27.1 27 1 decreased brown adipose tissue mass 0.0473556591335084 0.190764699748344 1.08301637175459 0.6 27.1 27 1 small petrosal ganglion 0.102786939189756 0.328008353091108 1.08301637175459 0.6 27.1 27 1 enlarged testis 0.102786939189756 0.328008353091108 1.08301637175459 0.6 27.1 27 1 abnormal prostate gland epithelium morphology 0.102786939189756 0.328008353091108 1.08301637175459 0.6 27.1 27 1 abnormal epidermis suprabasal layer morphology 0.102786939189756 0.328008353091108 1.08301637175459 0.6 27.1 27 1 fused cornea and lens 0.102786939189756 0.328008353091108 1.08301637175459 0.6 27.1 27 1 abnormal mammary gland physiology 0.102786939189756 0.328008353091108 1.08301637175459 0.6 27.1 27 1 decreased incidence of induced tumors 0.102786939189756 0.328008353091108 1.08301637175459 0.6 27.1 27 1 impaired social transmission of food preference 0.102786939189756 0.328008353091108 1.08301637175459 0.6 27.1 27 1 abnormal primordial germ cell migration 0.102786939189756 0.328008353091108 1.08301637175459 0.6 27.1 27 1 primary sex reversal 0.102786939189756 0.328008353091108 1.08301637175459 0.6 27.1 27 1 aneurysm 0.102786939189756 0.328008353091108 1.08301637175459 0.6 27.1 27 1 abnormal glial cell physiology 0.102786939189756 0.328008353091108 1.08301637175459 0.6 27.1 27 1 abnormal pillar cell morphology 0.102786939189756 0.328008353091108 1.08301637175459 0.6 27.1 27 1 abnormal corneal endothelium morphology 0.102786939189756 0.328008353091108 1.08301637175459 0.6 27.1 27 1 abnormal gonadal fat pad morphology 0.102786939189756 0.328008353091108 1.08301637175459 0.6 27.1 27 1 absent inguinal lymph nodes 0.102786939189756 0.328008353091108 1.08301637175459 0.6 27.1 27 1 decreased transitional stage T2 B cell number 0.102786939189756 0.328008353091108 1.08301637175459 0.6 27.1 27 1 umbilical hernia 0.102786939189756 0.328008353091108 1.08301637175459 0.6 27.1 27 1 increased kidney iron level 0.102786939189756 0.328008353091108 1.08301637175459 0.6 27.1 27 1 abnormal left subclavian artery morphology 0.102786939189756 0.328008353091108 1.08301637175459 0.6 27.1 27 1 fusion of atlas and odontoid process 0.102786939189756 0.328008353091108 1.08301637175459 0.6 27.1 27 1 decreased trabecular bone connectivity density 0.102786939189756 0.328008353091108 1.08301637175459 0.6 27.1 27 1 abnormal adaptive thermogenesis 0.102786939189756 0.328008353091108 1.08301637175459 0.6 27.1 27 1 decreased macrophage cytokine production 0.102786939189756 0.328008353091108 1.08301637175459 0.6 27.1 27 1 decreased circulating lactate level 0.102786939189756 0.328008353091108 1.08301637175459 0.6 27.1 27 1 reduced male fertility 7.68843237891311e-14 7.80611246634545e-12 1.08142603934379 0.599118942731278 27.1 27 1 decreased body size 3.90855498086467e-45 2.77786586140025e-42 1.08120682059042 0.598997493734336 27.1 27 1 decreased erythrocyte cell number 5.28241428185407e-10 2.65454657093172e-08 1.0807169739377 0.598726114649682 27.1 27 1 abnormal neuromuscular synapse morphology 2.67733342753483e-05 0.000479127115179345 1.07800240707054 0.597222222222222 27.1 27 1 abnormal eye morphology 6.30507395999347e-09 2.70411577163513e-07 1.07782204862867 0.597122302158273 27.1 27 1 incomplete embryo turning 0.000188166672948778 0.00253007891329776 1.07668294268 0.596491228070175 27.1 27 1 liver hypoplasia 0.000362535224054736 0.00446438796948592 1.07607395911514 0.596153846153846 27.1 27 1 postnatal lethality, incomplete penetrance 1.88824933122297e-31 7.82836701902856e-29 1.07411834992092 0.595070422535211 27.1 27 1 increased brown adipose tissue amount 0.00266411675904827 0.0225025142211633 1.07325946750455 0.594594594594595 27.1 27 1 impaired skeletal muscle contractility 0.00266411675904827 0.0225025142211633 1.07325946750455 0.594594594594595 27.1 27 1 extramedullary hematopoiesis 5.09905862197013e-07 1.4171964605755e-05 1.072799236172 0.594339622641509 27.1 27 1 microcephaly 4.82731683594061e-05 0.000792604001940744 1.07255244545744 0.594202898550725 27.1 27 1 perimembraneous ventricular septal defect 4.82731683594061e-05 0.000792604001940744 1.07255244545744 0.594202898550725 27.1 27 1 increased circulating follicle stimulating hormone level 0.00524810741074275 0.0398008145860445 1.07173495121548 0.59375 27.1 27 1 small spleen 3.46706991345345e-06 7.87610631024243e-05 1.0711150929441 0.593406593406593 27.1 27 1 increased grip strength 3.46706991345345e-06 7.87610631024243e-05 1.0711150929441 0.593406593406593 27.1 27 1 increased circulating creatinine level 6.58290721968146e-06 0.000137604888310568 1.07042315812954 0.593023255813954 27.1 27 1 short snout 4.81700917290887e-07 1.34632700197874e-05 1.06964579926379 0.592592592592593 27.1 27 1 decreased platelet aggregation 0.000340961246018992 0.00421960746006091 1.06964579926379 0.592592592592593 27.1 27 1 abnormal trigeminal ganglion morphology 0.0104431863331131 0.0666087846246636 1.06964579926379 0.592592592592593 27.1 27 1 abnormal fetal cardiomyocyte proliferation 0.0104431863331131 0.0666087846246636 1.06964579926379 0.592592592592593 27.1 27 1 abnormal liver morphology 1.08026417369224e-10 6.3227226636693e-09 1.06889883990676 0.592178770949721 27.1 27 1 polydactyly 1.72536114972233e-06 4.16683093197505e-05 1.06828145513208 0.591836734693878 27.1 27 1 lethargy 3.27008797638915e-06 7.56683148024931e-05 1.06748925531366 0.591397849462366 27.1 27 1 abnormal circadian rhythm 0.00127714292631848 0.0124324891349597 1.06660703278861 0.590909090909091 27.1 27 1 abnormal astrocyte morphology 0.00127714292631848 0.0124324891349597 1.06660703278861 0.590909090909091 27.1 27 1 decreased blood urea nitrogen level 0.00127714292631848 0.0124324891349597 1.06660703278861 0.590909090909091 27.1 27 1 decreased sensitivity to induced morbidity/mortality 0.00127714292631848 0.0124324891349597 1.06660703278861 0.590909090909091 27.1 27 1 abnormal abdominal fat pad morphology 0.0210735859156734 0.112490439839566 1.06660703278861 0.590909090909091 27.1 27 1 abnormal germ layer development 0.0210735859156734 0.112490439839566 1.06660703278861 0.590909090909091 27.1 27 1 intracerebral hemorrhage 0.0210735859156734 0.112490439839566 1.06660703278861 0.590909090909091 27.1 27 1 abnormal oogenesis 0.0210735859156734 0.112490439839566 1.06660703278861 0.590909090909091 27.1 27 1 increased skin papilloma incidence 0.0210735859156734 0.112490439839566 1.06660703278861 0.590909090909091 27.1 27 1 increased coping response 0.0210735859156734 0.112490439839566 1.06660703278861 0.590909090909091 27.1 27 1 abnormal cochlear sensory epithelium morphology 0.0210735859156734 0.112490439839566 1.06660703278861 0.590909090909091 27.1 27 1 abnormal channel response 0.0210735859156734 0.112490439839566 1.06660703278861 0.590909090909091 27.1 27 1 abnormal female reproductive system physiology 0.0210735859156734 0.112490439839566 1.06660703278861 0.590909090909091 27.1 27 1 abnormal circulating lipid level 0.0210735859156734 0.112490439839566 1.06660703278861 0.590909090909091 27.1 27 1 increased mammary gland tumor incidence 0.0210735859156734 0.112490439839566 1.06660703278861 0.590909090909091 27.1 27 1 abnormal maternal nurturing 0.000166515221309379 0.00228213009921257 1.06526200500451 0.590163934426229 27.1 27 1 increased hepatocyte apoptosis 0.00249067618608771 0.0212176610030589 1.06450327138272 0.58974358974359 27.1 27 1 decreased percent body fat/body weight 4.27434509029507e-05 0.000708828894140599 1.0632352508093 0.589041095890411 27.1 27 1 overexpanded pulmonary alveoli 0.00489079491431326 0.037204441435334 1.06178075662215 0.588235294117647 27.1 27 1 abnormal nervous system development 0.00489079491431326 0.037204441435334 1.06178075662215 0.588235294117647 27.1 27 1 abnormal bone marrow cavity morphology 0.0434143944198503 0.184736475360005 1.06178075662215 0.588235294117647 27.1 27 1 abnormal interatrial septum morphology 0.0434143944198503 0.184736475360005 1.06178075662215 0.588235294117647 27.1 27 1 increased incidence of corneal inflammation 0.0434143944198503 0.184736475360005 1.06178075662215 0.588235294117647 27.1 27 1 increased aggression towards mice 0.0434143944198503 0.184736475360005 1.06178075662215 0.588235294117647 27.1 27 1 abnormal touch/ nociception 0.0434143944198503 0.184736475360005 1.06178075662215 0.588235294117647 27.1 27 1 abnormal involuntary movement 0.0434143944198503 0.184736475360005 1.06178075662215 0.588235294117647 27.1 27 1 abnormal tarsal bone morphology 0.0434143944198503 0.184736475360005 1.06178075662215 0.588235294117647 27.1 27 1 coloboma 0.0434143944198503 0.184736475360005 1.06178075662215 0.588235294117647 27.1 27 1 increased hepatoma incidence 0.0434143944198503 0.184736475360005 1.06178075662215 0.588235294117647 27.1 27 1 increased trabecular bone mass 0.0434143944198503 0.184736475360005 1.06178075662215 0.588235294117647 27.1 27 1 distended abdomen 0.000616813187821354 0.00687475989483878 1.06178075662215 0.588235294117647 27.1 27 1 thrombocytopenia 1.41421132905344e-08 5.5838899698737e-07 1.05811944366828 0.586206896551724 27.1 27 1 thrombocytosis 0.000299629037155791 0.0037547971280858 1.05811944366828 0.586206896551724 27.1 27 1 decreased granulocyte number 0.00969020855412146 0.0637682375089342 1.05811944366828 0.586206896551724 27.1 27 1 abnormal embryonic erythropoiesis 0.00969020855412146 0.0637682375089342 1.05811944366828 0.586206896551724 27.1 27 1 abnormal retinal pigmentation 1.04122475033146e-05 0.000209720369752997 1.05811944366828 0.586206896551724 27.1 27 1 liver fibrosis 0.00232228466734413 0.0200579274653421 1.05660133829716 0.585365853658537 27.1 27 1 abnormal cholesterol homeostasis 0.00232228466734413 0.0200579274653421 1.05660133829716 0.585365853658537 27.1 27 1 increased bone trabecula number 0.00232228466734413 0.0200579274653421 1.05660133829716 0.585365853658537 27.1 27 1 decreased circulating glucose level 6.64316091621277e-15 7.86898227575203e-13 1.05454999161289 0.584229390681004 27.1 27 1 decreased leukocyte cell number 4.70284436180627e-08 1.59226360196602e-06 1.05403053212125 0.583941605839416 27.1 27 1 abnormal heart left ventricle morphology 7.16306515735222e-05 0.00112772940372871 1.05293258365029 0.583333333333333 27.1 27 1 abnormal eating behavior 0.000280094394583638 0.00355526567901134 1.05293258365029 0.583333333333333 27.1 27 1 increased erythrocyte cell number 0.000280094394583638 0.00355526567901134 1.05293258365029 0.583333333333333 27.1 27 1 abnormal pharyngeal arch morphology 0.00454497286826559 0.0346798159810143 1.05293258365029 0.583333333333333 27.1 27 1 small heart 0.0011136256288654 0.010970866343773 1.05293258365029 0.583333333333333 27.1 27 1 decreased body height 0.0194340806006678 0.105320861643053 1.05293258365029 0.583333333333333 27.1 27 1 abnormal nursing 0.0194340806006678 0.105320861643053 1.05293258365029 0.583333333333333 27.1 27 1 abnormal truncus arteriosus septation 0.0194340806006678 0.105320861643053 1.05293258365029 0.583333333333333 27.1 27 1 abnormal lung saccule morphology 0.0194340806006678 0.105320861643053 1.05293258365029 0.583333333333333 27.1 27 1 abnormal supraoccipital bone morphology 0.092520828923357 0.303822524022245 1.05293258365029 0.583333333333333 27.1 27 1 mesocardia 0.092520828923357 0.303822524022245 1.05293258365029 0.583333333333333 27.1 27 1 abnormal superior cervical ganglion morphology 0.092520828923357 0.303822524022245 1.05293258365029 0.583333333333333 27.1 27 1 absent optic nerve 0.092520828923357 0.303822524022245 1.05293258365029 0.583333333333333 27.1 27 1 interstitial pneumonia 0.092520828923357 0.303822524022245 1.05293258365029 0.583333333333333 27.1 27 1 increased papilloma incidence 0.092520828923357 0.303822524022245 1.05293258365029 0.583333333333333 27.1 27 1 loss of dopaminergic neurons 0.092520828923357 0.303822524022245 1.05293258365029 0.583333333333333 27.1 27 1 dilated bile duct 0.092520828923357 0.303822524022245 1.05293258365029 0.583333333333333 27.1 27 1 increased fear-related response 0.092520828923357 0.303822524022245 1.05293258365029 0.583333333333333 27.1 27 1 absent ovary 0.092520828923357 0.303822524022245 1.05293258365029 0.583333333333333 27.1 27 1 abnormal nucleotide metabolism 0.092520828923357 0.303822524022245 1.05293258365029 0.583333333333333 27.1 27 1 abnormal defecation 0.092520828923357 0.303822524022245 1.05293258365029 0.583333333333333 27.1 27 1 abnormal rostral-caudal body axis extension 0.092520828923357 0.303822524022245 1.05293258365029 0.583333333333333 27.1 27 1 pale placenta 0.092520828923357 0.303822524022245 1.05293258365029 0.583333333333333 27.1 27 1 small parietal bone 0.092520828923357 0.303822524022245 1.05293258365029 0.583333333333333 27.1 27 1 abnormal patella morphology 0.092520828923357 0.303822524022245 1.05293258365029 0.583333333333333 27.1 27 1 hydrometra 0.092520828923357 0.303822524022245 1.05293258365029 0.583333333333333 27.1 27 1 impaired behavioral response to cocaine 0.092520828923357 0.303822524022245 1.05293258365029 0.583333333333333 27.1 27 1 decreased prostaglandin level 0.092520828923357 0.303822524022245 1.05293258365029 0.583333333333333 27.1 27 1 increased heart weight 4.41427774129011e-08 1.55131005998208e-06 1.05185043299906 0.58273381294964 27.1 27 1 abnormal glucose homeostasis 4.17006044418195e-10 2.11694394998012e-08 1.05127962825995 0.582417582417582 27.1 27 1 perinatal lethality, complete penetrance 1.4932146278347e-11 9.77466154404948e-10 1.05081400702323 0.582159624413146 27.1 27 1 internal hemorrhage 0.000136693949717003 0.00194300685669168 1.05068752483654 0.582089552238806 27.1 27 1 abnormal embryo turning 0.000537998309325914 0.00609690566946794 1.05019769382263 0.581818181818182 27.1 27 1 abnormal rostral-caudal axis patterning 0.000537998309325914 0.00609690566946794 1.05019769382263 0.581818181818182 27.1 27 1 cardiac hypertrophy 4.52677166336506e-06 9.93630125198395e-05 1.04986280935394 0.581632653061224 27.1 27 1 hypoglycemia 8.56264857829227e-06 0.000173874190518384 1.04808035976251 0.580645161290323 27.1 27 1 abnormal eyelid morphology 0.00896543181237871 0.0593125309396065 1.04808035976251 0.580645161290323 27.1 27 1 abnormal retinal photoreceptor layer morphology 0.00896543181237871 0.0593125309396065 1.04808035976251 0.580645161290323 27.1 27 1 small cranium 0.00896543181237871 0.0593125309396065 1.04808035976251 0.580645161290323 27.1 27 1 postnatal lethality, complete penetrance 1.97074379847222e-19 3.6312779249627e-17 1.04747697440858 0.580310880829015 27.1 27 1 decreased heart rate 4.23590956008249e-06 9.40787949170107e-05 1.04691582602944 0.58 27.1 27 1 abnormal interventricular septum morphology 0.00103675211991305 0.0102338130884274 1.04691582602944 0.58 27.1 27 1 thymus hypoplasia 7.28844168876251e-08 2.36993447069238e-06 1.04639262971458 0.579710144927536 27.1 27 1 impaired righting response 8.0047923980898e-06 0.000164561331324367 1.04501579730706 0.578947368421053 27.1 27 1 abnormal axial skeleton morphology 6.25182394875315e-05 0.00100656388818922 1.04501579730706 0.578947368421053 27.1 27 1 decreased hair follicle number 0.00421371598744612 0.0322511339039145 1.04501579730706 0.578947368421053 27.1 27 1 hyporesponsive to tactile stimuli 0.00421371598744612 0.0322511339039145 1.04501579730706 0.578947368421053 27.1 27 1 decreased threshold for auditory brainstem response 0.00421371598744612 0.0322511339039145 1.04501579730706 0.578947368421053 27.1 27 1 small superior vagus ganglion 0.0396598102261909 0.174146121690467 1.04501579730706 0.578947368421053 27.1 27 1 stereotypic behavior 0.0396598102261909 0.174146121690467 1.04501579730706 0.578947368421053 27.1 27 1 increased susceptibility to ischemic brain injury 0.0396598102261909 0.174146121690467 1.04501579730706 0.578947368421053 27.1 27 1 abnormal optic vesicle formation 0.0396598102261909 0.174146121690467 1.04501579730706 0.578947368421053 27.1 27 1 abnormal photoreceptor inner segment morphology 0.0396598102261909 0.174146121690467 1.04501579730706 0.578947368421053 27.1 27 1 abnormal sternebra morphology 0.0396598102261909 0.174146121690467 1.04501579730706 0.578947368421053 27.1 27 1 abnormal blastocyst morphology 0.0396598102261909 0.174146121690467 1.04501579730706 0.578947368421053 27.1 27 1 decreased eye pigmentation 0.0396598102261909 0.174146121690467 1.04501579730706 0.578947368421053 27.1 27 1 decreased fertilization frequency 0.0396598102261909 0.174146121690467 1.04501579730706 0.578947368421053 27.1 27 1 increased liver cholesterol level 0.0396598102261909 0.174146121690467 1.04501579730706 0.578947368421053 27.1 27 1 shortened RR interval 0.0396598102261909 0.174146121690467 1.04501579730706 0.578947368421053 27.1 27 1 abnormal eye electrophysiology 5.17394127919393e-07 1.43001988133277e-05 1.04423066147137 0.578512396694215 27.1 27 1 postnatal growth retardation 1.56066143051901e-29 5.17619374455472e-27 1.04408441067844 0.57843137254902 27.1 27 1 decreased circulating HDL cholesterol level 2.57314613465627e-07 7.71168796380419e-06 1.0435313998677 0.578125 27.1 27 1 abnormal lens morphology 2.57314613465627e-07 7.71168796380419e-06 1.0435313998677 0.578125 27.1 27 1 irregular heartbeat 0.00200572640171412 0.0175987457645992 1.0429046542822 0.577777777777778 27.1 27 1 increased circulating corticosterone level 0.00200572640171412 0.0175987457645992 1.0429046542822 0.577777777777778 27.1 27 1 abnormal cell migration 0.00200572640171412 0.0175987457645992 1.0429046542822 0.577777777777778 27.1 27 1 abnormal metabolism 0.00200572640171412 0.0175987457645992 1.0429046542822 0.577777777777778 27.1 27 1 decreased kidney weight 0.000963555865684919 0.00992482491052272 1.04136189591787 0.576923076923077 27.1 27 1 increased percent body fat/body weight 0.000963555865684919 0.00992482491052272 1.04136189591787 0.576923076923077 27.1 27 1 thick skin 0.0178712715174881 0.0974885699555959 1.04136189591787 0.576923076923077 27.1 27 1 abnormal erythrocyte osmotic lysis 0.0178712715174881 0.0974885699555959 1.04136189591787 0.576923076923077 27.1 27 1 small testis 7.48982894166312e-14 7.76289562182792e-12 1.03985267577886 0.576086956521739 27.1 27 1 abnormal tail morphology 0.00022673270443884 0.00300798721222194 1.03925813451198 0.575757575757576 27.1 27 1 abnormal QRS complex 0.00827556669985647 0.0552630125258872 1.03925813451198 0.575757575757576 27.1 27 1 abnormal fertility/fecundity 0.000110768149256232 0.0016207986545581 1.03850884962769 0.575342465753425 27.1 27 1 decreased circulating phosphate level 0.00389893582343886 0.0306917812050765 1.03789068959815 0.575 27.1 27 1 head bobbing 0.00389893582343886 0.0306917812050765 1.03789068959815 0.575 27.1 27 1 increased respiratory quotient 0.00185903297206094 0.0168568333535414 1.0369305687012 0.574468085106383 27.1 27 1 increased circulating cholesterol level 3.22561971706277e-09 1.43280875824886e-07 1.0358395222274 0.573863636363636 27.1 27 1 decreased circulating alanine transaminase level 0.000210767140107085 0.00282632485723113 1.03523623770659 0.573529411764706 27.1 27 1 enlarged heart 1.26195861212003e-11 8.48411364229341e-10 1.03477857358736 0.573275862068966 27.1 27 1 reduced female fertility 1.26195861212003e-11 8.48411364229341e-10 1.03477857358736 0.573275862068966 27.1 27 1 increased susceptibility to pharmacologically induced seizures 1.22600742899486e-05 0.00023825730309568 1.03413021608511 0.572916666666667 27.1 27 1 postnatal lethality 1.12635879305852e-08 4.59314343890667e-07 1.03299754334022 0.572289156626506 27.1 27 1 decreased bone mineral content 1.75336584470938e-10 9.91249440616951e-09 1.03268388011856 0.572115384615385 27.1 27 1 ovary cysts 0.00762438015392134 0.0511893269443437 1.0314441635758 0.571428571428571 27.1 27 1 holoprosencephaly 0.00762438015392134 0.0511893269443437 1.0314441635758 0.571428571428571 27.1 27 1 decreased bone mineralization 0.00762438015392134 0.0511893269443437 1.0314441635758 0.571428571428571 27.1 27 1 abnormal circulating cholesterol level 0.0163988355681383 0.0903479589717474 1.0314441635758 0.571428571428571 27.1 27 1 abnormal respiration 0.0163988355681383 0.0903479589717474 1.0314441635758 0.571428571428571 27.1 27 1 small ears 0.0361451159421954 0.161710388320524 1.0314441635758 0.571428571428571 27.1 27 1 abnormal hematopoietic system physiology 0.0361451159421954 0.161710388320524 1.0314441635758 0.571428571428571 27.1 27 1 increased incidence of induced tumors 0.0361451159421954 0.161710388320524 1.0314441635758 0.571428571428571 27.1 27 1 liver degeneration 0.0361451159421954 0.161710388320524 1.0314441635758 0.571428571428571 27.1 27 1 decreased cochlear outer hair cell number 0.0361451159421954 0.161710388320524 1.0314441635758 0.571428571428571 27.1 27 1 embryonic lethality at implantation, complete penetrance 0.0361451159421954 0.161710388320524 1.0314441635758 0.571428571428571 27.1 27 1 increased bone ossification 0.0361451159421954 0.161710388320524 1.0314441635758 0.571428571428571 27.1 27 1 absent atrioventricular cushions 0.0831493323643963 0.279505357103292 1.0314441635758 0.571428571428571 27.1 27 1 irregularly shaped pupil 0.0831493323643963 0.279505357103292 1.0314441635758 0.571428571428571 27.1 27 1 increased aggression towards males 0.0831493323643963 0.279505357103292 1.0314441635758 0.571428571428571 27.1 27 1 abnormal pinna reflex 0.0831493323643963 0.279505357103292 1.0314441635758 0.571428571428571 27.1 27 1 abnormal adrenal gland secretion 0.0831493323643963 0.279505357103292 1.0314441635758 0.571428571428571 27.1 27 1 abnormal endplate potential 0.0831493323643963 0.279505357103292 1.0314441635758 0.571428571428571 27.1 27 1 decreased coping response 0.0831493323643963 0.279505357103292 1.0314441635758 0.571428571428571 27.1 27 1 abnormal prepulse inhibition 0.0831493323643963 0.279505357103292 1.0314441635758 0.571428571428571 27.1 27 1 intestinal obstruction 0.0831493323643963 0.279505357103292 1.0314441635758 0.571428571428571 27.1 27 1 abnormal ventral body wall morphology 0.0831493323643963 0.279505357103292 1.0314441635758 0.571428571428571 27.1 27 1 skeletal muscle necrosis 0.0831493323643963 0.279505357103292 1.0314441635758 0.571428571428571 27.1 27 1 abnormal glucose tolerance 0.0831493323643963 0.279505357103292 1.0314441635758 0.571428571428571 27.1 27 1 spina bifida occulta 0.0831493323643963 0.279505357103292 1.0314441635758 0.571428571428571 27.1 27 1 increased stomach tumor incidence 0.0831493323643963 0.279505357103292 1.0314441635758 0.571428571428571 27.1 27 1 pulmonary alveolar hemorrhage 0.0831493323643963 0.279505357103292 1.0314441635758 0.571428571428571 27.1 27 1 decreased compact bone area 0.0831493323643963 0.279505357103292 1.0314441635758 0.571428571428571 27.1 27 1 male infertility 6.03339676608256e-23 1.36437040505731e-20 1.02990622496212 0.570576540755467 27.1 27 1 abnormal bone mineralization 1.28872333329162e-06 3.20569929156291e-05 1.0293130805932 0.570247933884298 27.1 27 1 abnormal placenta labyrinth morphology 8.88761736272431e-05 0.00132780469608269 1.02818009976701 0.569620253164557 27.1 27 1 decreased B cell proliferation 8.88761736272431e-05 0.00132780469608269 1.02818009976701 0.569620253164557 27.1 27 1 decreased food intake 8.88761736272431e-05 0.00132780469608269 1.02818009976701 0.569620253164557 27.1 27 1 abnormal spermiogenesis 0.000767158436728269 0.0082254595317309 1.02699828356039 0.568965517241379 27.1 27 1 anemia 2.46326749513868e-10 1.33203867264293e-08 1.02655580261098 0.568720379146919 27.1 27 1 microphthalmia 6.83305799128287e-08 2.26131272199912e-06 1.02638806473474 0.568627450980392 27.1 27 1 abnormal seminiferous tubule morphology 1.37138397543393e-07 4.3734841524255e-06 1.02614564903688 0.568493150684932 27.1 27 1 decreased birth weight 1.99609328565356e-05 0.000374738267778357 1.0260155100833 0.568421052631579 27.1 27 1 small seminiferous tubules 0.000168263271976882 0.00229975213759612 1.02447494625434 0.567567567567568 27.1 27 1 rib fusion 0.000344714520970907 0.00425547082340015 1.0237468190715 0.567164179104478 27.1 27 1 abnormal heart morphology 4.96999224973326e-11 3.01533066371012e-09 1.02363019263962 0.567099567099567 27.1 27 1 epidermal hyperplasia 0.000709417584185566 0.00777390414388368 1.022848795546 0.566666666666667 27.1 27 1 increased metastatic potential 0.0150229150236111 0.0871083942219873 1.022848795546 0.566666666666667 27.1 27 1 disorganized myocardium 0.0150229150236111 0.0871083942219873 1.022848795546 0.566666666666667 27.1 27 1 liver hemorrhage 0.0150229150236111 0.0871083942219873 1.022848795546 0.566666666666667 27.1 27 1 abnormal fat pad morphology 0.0150229150236111 0.0871083942219873 1.022848795546 0.566666666666667 27.1 27 1 increased bone mineral density 4.2051125876488e-06 9.38136104195191e-05 1.02231633911938 0.566371681415929 27.1 27 1 abnormal sacral vertebrae morphology 0.0328902131564547 0.148618356451737 1.02023281397171 0.565217391304348 27.1 27 1 dilated heart 0.0328902131564547 0.148618356451737 1.02023281397171 0.565217391304348 27.1 27 1 abnormal corneal stroma morphology 0.0328902131564547 0.148618356451737 1.02023281397171 0.565217391304348 27.1 27 1 impaired glucose tolerance 1.72729185452064e-11 1.11600999691431e-09 1.01896701643577 0.564516129032258 27.1 27 1 abnormal heart looping 0.00644353220096875 0.04607905528119 1.01822052045303 0.564102564102564 27.1 27 1 abnormal iris morphology 0.00644353220096875 0.04607905528119 1.01822052045303 0.564102564102564 27.1 27 1 failure of heart looping 0.00644353220096875 0.04607905528119 1.01822052045303 0.564102564102564 27.1 27 1 increased body weight 2.36685030233022e-10 1.29396486308713e-08 1.01532784851993 0.5625 27.1 27 1 kidney cortex cysts 0.0137448489001964 0.0823626247867518 1.01532784851993 0.5625 27.1 27 1 abnormal embryonic hematopoiesis 0.0137448489001964 0.0823626247867518 1.01532784851993 0.5625 27.1 27 1 abnormal tympanic ring morphology 0.0746936815718315 0.256807923856159 1.01532784851993 0.5625 27.1 27 1 increased pancreatic beta cell number 0.0746936815718315 0.256807923856159 1.01532784851993 0.5625 27.1 27 1 impaired behavioral response to addictive substance 0.0746936815718315 0.256807923856159 1.01532784851993 0.5625 27.1 27 1 increased heart left ventricle size 0.0746936815718315 0.256807923856159 1.01532784851993 0.5625 27.1 27 1 decreased bone marrow cell number 0.00027224391456086 0.00350884319932715 1.01378244844608 0.561643835616438 27.1 27 1 sparse hair 0.000123198060941655 0.00176631225701652 1.01257628253478 0.560975609756098 27.1 27 1 abnormal vascular development 0.000558044667957346 0.00630970959792681 1.01190923623535 0.560606060606061 27.1 27 1 decreased double-positive T cell number 2.55468276328725e-05 0.000459762021060431 1.01081528030428 0.56 27.1 27 1 decreased circulating alkaline phosphatase level 0.00259080079984217 0.0219952798280116 1.01081528030428 0.56 27.1 27 1 testicular atrophy 0.00259080079984217 0.0219952798280116 1.01081528030428 0.56 27.1 27 1 ruffled hair 0.0298967378754199 0.136080760228924 1.01081528030428 0.56 27.1 27 1 abnormal thyroid gland morphology 0.0298967378754199 0.136080760228924 1.01081528030428 0.56 27.1 27 1 decreased placenta weight 0.0298967378754199 0.136080760228924 1.01081528030428 0.56 27.1 27 1 abnormal cranium morphology 1.22609637872839e-06 3.0807219617039e-05 1.01027646618898 0.559701492537313 27.1 27 1 abnormal oocyte morphology 0.0125629442948779 0.0764066599841289 1.00869171879104 0.558823529411765 27.1 27 1 lung hemorrhage 0.0125629442948779 0.0764066599841289 1.00869171879104 0.558823529411765 27.1 27 1 abnormal endoderm development 0.0125629442948779 0.0764066599841289 1.00869171879104 0.558823529411765 27.1 27 1 abnormal vision 0.0125629442948779 0.0764066599841289 1.00869171879104 0.558823529411765 27.1 27 1 abnormal blood vessel morphology 5.23160059667425e-07 1.43796756731792e-05 1.00832558749565 0.558620689655172 27.1 27 1 abnormal left-right axis patterning 0.00542235750976409 0.0406865127186406 1.00745709000427 0.558139534883721 27.1 27 1 abnormal blood circulation 0.00542235750976409 0.0406865127186406 1.00745709000427 0.558139534883721 27.1 27 1 delayed endochondral bone ossification 0.00542235750976409 0.0406865127186406 1.00745709000427 0.558139534883721 27.1 27 1 absent corpus luteum 0.00238056065705102 0.0203143898264645 1.00664983272061 0.557692307692308 27.1 27 1 eyelids open at birth 0.00238056065705102 0.0203143898264645 1.00664983272061 0.557692307692308 27.1 27 1 abnormal female meiosis 0.00238056065705102 0.0203143898264645 1.00664983272061 0.557692307692308 27.1 27 1 small kidney 9.68804798198248e-05 0.00143446543780842 1.00507201166619 0.556818181818182 27.1 27 1 enlarged spleen 3.77959485705354e-12 2.8064902110211e-10 1.0027929368098 0.555555555555556 27.1 27 1 abnormal rib morphology 1.79907118661553e-06 4.32385466348419e-05 1.0027929368098 0.555555555555556 27.1 27 1 increased B cell number 8.51697218422437e-06 0.000173655477936542 1.0027929368098 0.555555555555556 27.1 27 1 increased circulating aspartate transaminase level 0.000972515815181377 0.00999641772836229 1.0027929368098 0.555555555555556 27.1 27 1 abnormal small intestine morphology 0.00218589740276864 0.0190119573055489 1.0027929368098 0.555555555555556 27.1 27 1 abnormal retinal blood vessel morphology 0.011473639260991 0.0720724183376645 1.0027929368098 0.555555555555556 27.1 27 1 abnormal heart valve morphology 0.0271563779979571 0.131547515031184 1.0027929368098 0.555555555555556 27.1 27 1 thin epidermis 0.0271563779979571 0.131547515031184 1.0027929368098 0.555555555555556 27.1 27 1 abnormal single cell response 0.0271563779979571 0.131547515031184 1.0027929368098 0.555555555555556 27.1 27 1 abnormal heart shape 0.0671048313094998 0.233949919947275 1.0027929368098 0.555555555555556 27.1 27 1 abnormal mammary gland morphology 0.0671048313094998 0.233949919947275 1.0027929368098 0.555555555555556 27.1 27 1 abnormal phrenic nerve morphology 0.0671048313094998 0.233949919947275 1.0027929368098 0.555555555555556 27.1 27 1 blepharoptosis 0.0671048313094998 0.233949919947275 1.0027929368098 0.555555555555556 27.1 27 1 abnormal white adipose tissue morphology 0.0671048313094998 0.233949919947275 1.0027929368098 0.555555555555556 27.1 27 1 abnormal body wall morphology 0.0671048313094998 0.233949919947275 1.0027929368098 0.555555555555556 27.1 27 1 increased circulating glycerol level 0.0671048313094998 0.233949919947275 1.0027929368098 0.555555555555556 27.1 27 1 abnormal eye anterior chamber morphology 0.0671048313094998 0.233949919947275 1.0027929368098 0.555555555555556 27.1 27 1 increased susceptibility to autoimmune disorder 0.0671048313094998 0.233949919947275 1.0027929368098 0.555555555555556 27.1 27 1 jerky movement 0.0671048313094998 0.233949919947275 1.0027929368098 0.555555555555556 27.1 27 1 decreased tumor latency 0.0671048313094998 0.233949919947275 1.0027929368098 0.555555555555556 27.1 27 1 primary atelectasis 0.0671048313094998 0.233949919947275 1.0027929368098 0.555555555555556 27.1 27 1 abnormal metanephric mesenchyme morphology 0.0671048313094998 0.233949919947275 1.0027929368098 0.555555555555556 27.1 27 1 abnormal geniculate ganglion morphology 0.182850802357935 0.448782803024533 1.0027929368098 0.555555555555556 27.1 27 1 small nodose ganglion 0.182850802357935 0.448782803024533 1.0027929368098 0.555555555555556 27.1 27 1 abnormal vagina epithelium morphology 0.182850802357935 0.448782803024533 1.0027929368098 0.555555555555556 27.1 27 1 decreased level of surface class I molecules 0.182850802357935 0.448782803024533 1.0027929368098 0.555555555555556 27.1 27 1 abnormal lung volume 0.182850802357935 0.448782803024533 1.0027929368098 0.555555555555556 27.1 27 1 abnormal vomeronasal organ morphology 0.182850802357935 0.448782803024533 1.0027929368098 0.555555555555556 27.1 27 1 abnormal thymus lobule morphology 0.182850802357935 0.448782803024533 1.0027929368098 0.555555555555556 27.1 27 1 polycythemia 0.182850802357935 0.448782803024533 1.0027929368098 0.555555555555556 27.1 27 1 abnormal postural reflex 0.182850802357935 0.448782803024533 1.0027929368098 0.555555555555556 27.1 27 1 enlarged otoliths 0.182850802357935 0.448782803024533 1.0027929368098 0.555555555555556 27.1 27 1 abnormal lens capsule morphology 0.182850802357935 0.448782803024533 1.0027929368098 0.555555555555556 27.1 27 1 biliary cyst 0.182850802357935 0.448782803024533 1.0027929368098 0.555555555555556 27.1 27 1 pancreas cysts 0.182850802357935 0.448782803024533 1.0027929368098 0.555555555555556 27.1 27 1 priapism 0.182850802357935 0.448782803024533 1.0027929368098 0.555555555555556 27.1 27 1 premature neuronal precursor differentiation 0.182850802357935 0.448782803024533 1.0027929368098 0.555555555555556 27.1 27 1 abnormal ovary physiology 0.182850802357935 0.448782803024533 1.0027929368098 0.555555555555556 27.1 27 1 abnormal proprioceptive neuron morphology 0.182850802357935 0.448782803024533 1.0027929368098 0.555555555555556 27.1 27 1 small scapula 0.182850802357935 0.448782803024533 1.0027929368098 0.555555555555556 27.1 27 1 decreased cochlear hair cell number 0.182850802357935 0.448782803024533 1.0027929368098 0.555555555555556 27.1 27 1 liver hyperplasia 0.182850802357935 0.448782803024533 1.0027929368098 0.555555555555556 27.1 27 1 abnormal posterior eye segment morphology 0.182850802357935 0.448782803024533 1.0027929368098 0.555555555555556 27.1 27 1 abnormal oxygen consumption 0.182850802357935 0.448782803024533 1.0027929368098 0.555555555555556 27.1 27 1 axonal spheroids 0.182850802357935 0.448782803024533 1.0027929368098 0.555555555555556 27.1 27 1 abnormal incisor color 0.182850802357935 0.448782803024533 1.0027929368098 0.555555555555556 27.1 27 1 retropulsion 0.182850802357935 0.448782803024533 1.0027929368098 0.555555555555556 27.1 27 1 prolonged RR interval 0.182850802357935 0.448782803024533 1.0027929368098 0.555555555555556 27.1 27 1 iris coloboma 0.182850802357935 0.448782803024533 1.0027929368098 0.555555555555556 27.1 27 1 fusion of atlas and occipital bones 0.182850802357935 0.448782803024533 1.0027929368098 0.555555555555556 27.1 27 1 increased myeloid cell number 0.182850802357935 0.448782803024533 1.0027929368098 0.555555555555556 27.1 27 1 decreased fatty acid oxidation 0.182850802357935 0.448782803024533 1.0027929368098 0.555555555555556 27.1 27 1 adipose tissue inflammation 0.182850802357935 0.448782803024533 1.0027929368098 0.555555555555556 27.1 27 1 cardiomyopathy 0.00496827938117984 0.037736167818885 1.0027929368098 0.555555555555556 27.1 27 1 neonatal lethality, complete penetrance 3.00794606378268e-18 4.82726827978027e-16 1.00147347241927 0.554824561403509 27.1 27 1 cochlear ganglion degeneration 0.00183987820639069 0.0168568333535414 0.995877123452496 0.551724137931034 27.1 27 1 lordosis 0.0246556072776975 0.124277250462559 0.995877123452496 0.551724137931034 27.1 27 1 decreased trophoblast giant cell number 0.0246556072776975 0.124277250462559 0.995877123452496 0.551724137931034 27.1 27 1 short sternum 0.0246556072776975 0.124277250462559 0.995877123452496 0.551724137931034 27.1 27 1 increased retinal apoptosis 0.0246556072776975 0.124277250462559 0.995877123452496 0.551724137931034 27.1 27 1 abnormal cornea morphology 0.000339451642787048 0.00421140130390415 0.995079144988191 0.551282051282051 27.1 27 1 abnormal kidney development 0.00168677262226894 0.015714782389116 0.992765007441707 0.55 27.1 27 1 abnormal pancreatic beta cell morphology 0.00955359444017188 0.0631196976624902 0.992765007441707 0.55 27.1 27 1 increased mammary adenocarcinoma incidence 0.060309884979647 0.213400908800671 0.992765007441707 0.55 27.1 27 1 decreased myocardial infarction size 0.060309884979647 0.213400908800671 0.992765007441707 0.55 27.1 27 1 absent placental labyrinth 0.060309884979647 0.213400908800671 0.992765007441707 0.55 27.1 27 1 abnormal optic stalk morphology 0.060309884979647 0.213400908800671 0.992765007441707 0.55 27.1 27 1 dilated vasculature 0.060309884979647 0.213400908800671 0.992765007441707 0.55 27.1 27 1 respiratory failure 9.44780259362091e-07 2.44806343246167e-05 0.992167316287317 0.549668874172185 27.1 27 1 abnormal cervical vertebrae morphology 0.0038087920527629 0.0300773658134848 0.990995372847336 0.549019607843137 27.1 27 1 abnormal definitive hematopoiesis 0.000119490801733192 0.00172810098436812 0.989853673109033 0.548387096774194 27.1 27 1 decreased cardiac muscle contractility 5.00852541222244e-05 0.000816964391010054 0.98929380112198 0.548076923076923 27.1 27 1 arrest of spermatogenesis 0.000263199172715981 0.00340108021886236 0.988467323426807 0.547619047619048 27.1 27 1 disheveled coat 0.00871210699408751 0.057944829272173 0.988467323426807 0.547619047619048 27.1 27 1 skin edema 0.00871210699408751 0.057944829272173 0.988467323426807 0.547619047619048 27.1 27 1 abnormal coat/ hair morphology 0.00348289454280017 0.028545964333494 0.987656439650411 0.547169811320755 27.1 27 1 increased circulating bilirubin level 0.00348289454280017 0.028545964333494 0.987656439650411 0.547169811320755 27.1 27 1 cyanosis 5.27866536131783e-08 1.76250739413129e-06 0.987124297172151 0.546875 27.1 27 1 abnormal neurocranium morphology 0.000582488129997336 0.00651208639716123 0.986748249820848 0.546666666666667 27.1 27 1 decreased hemoglobin content 3.19393036463862e-06 7.42514185237248e-05 0.985724120864106 0.546099290780142 27.1 27 1 obese 0.000534125417370982 0.00609690566946794 0.984560337958717 0.545454545454545 27.1 27 1 abnormal skin morphology 0.00129683078040461 0.0125520099854337 0.984560337958717 0.545454545454545 27.1 27 1 belly spot 0.0203079875406042 0.109698412610756 0.984560337958717 0.545454545454545 27.1 27 1 abnormal ovarian folliculogenesis 0.0203079875406042 0.109698412610756 0.984560337958717 0.545454545454545 27.1 27 1 increased liver weight 0.00022179070908582 0.00295820047641275 0.984560337958717 0.545454545454545 27.1 27 1 teratozoospermia 0.00022179070908582 0.00295820047641275 0.984560337958717 0.545454545454545 27.1 27 1 abnormal amino acid level 0.00794228658370896 0.0531469108268271 0.984560337958717 0.545454545454545 27.1 27 1 abnormal enterocyte morphology 0.0542309519740218 0.21083722131187 0.984560337958717 0.545454545454545 27.1 27 1 testis hypoplasia 0.0542309519740218 0.21083722131187 0.984560337958717 0.545454545454545 27.1 27 1 abnormal chorion morphology 0.0542309519740218 0.21083722131187 0.984560337958717 0.545454545454545 27.1 27 1 prolonged PR interval 0.0542309519740218 0.21083722131187 0.984560337958717 0.545454545454545 27.1 27 1 abnormal sperm midpiece morphology 0.0542309519740218 0.21083722131187 0.984560337958717 0.545454545454545 27.1 27 1 pulmonary vascular congestion 0.0542309519740218 0.21083722131187 0.984560337958717 0.545454545454545 27.1 27 1 abnormal food preference 0.159866141987428 0.403371914842955 0.984560337958717 0.545454545454545 27.1 27 1 abnormal proximal-distal axis patterning 0.159866141987428 0.403371914842955 0.984560337958717 0.545454545454545 27.1 27 1 secondary sex reversal 0.159866141987428 0.403371914842955 0.984560337958717 0.545454545454545 27.1 27 1 abnormal fear/anxiety-related behavior 0.159866141987428 0.403371914842955 0.984560337958717 0.545454545454545 27.1 27 1 patent ductus arteriosus 0.159866141987428 0.403371914842955 0.984560337958717 0.545454545454545 27.1 27 1 rectal hemorrhage 0.159866141987428 0.403371914842955 0.984560337958717 0.545454545454545 27.1 27 1 impaired luteinization 0.159866141987428 0.403371914842955 0.984560337958717 0.545454545454545 27.1 27 1 dilated renal glomerular capsule 0.159866141987428 0.403371914842955 0.984560337958717 0.545454545454545 27.1 27 1 abnormal ureter development 0.159866141987428 0.403371914842955 0.984560337958717 0.545454545454545 27.1 27 1 abnormal pituitary gland development 0.159866141987428 0.403371914842955 0.984560337958717 0.545454545454545 27.1 27 1 abnormal coronal suture morphology 0.159866141987428 0.403371914842955 0.984560337958717 0.545454545454545 27.1 27 1 abnormal crista ampullaris neuroepithelium morphology 0.159866141987428 0.403371914842955 0.984560337958717 0.545454545454545 27.1 27 1 abnormal Bruch membrane morphology 0.159866141987428 0.403371914842955 0.984560337958717 0.545454545454545 27.1 27 1 increased circulating triiodothyronine level 0.159866141987428 0.403371914842955 0.984560337958717 0.545454545454545 27.1 27 1 palatal shelf hypoplasia 0.159866141987428 0.403371914842955 0.984560337958717 0.545454545454545 27.1 27 1 decreased palatine bone horizontal plate size 0.159866141987428 0.403371914842955 0.984560337958717 0.545454545454545 27.1 27 1 abnormal extraembryonic ectoderm morphology 0.159866141987428 0.403371914842955 0.984560337958717 0.545454545454545 27.1 27 1 decreased embryonic cilium length 0.159866141987428 0.403371914842955 0.984560337958717 0.545454545454545 27.1 27 1 abnormal phrenic nerve innervation pattern to diaphragm 0.159866141987428 0.403371914842955 0.984560337958717 0.545454545454545 27.1 27 1 female infertility 2.33722108608628e-10 1.29196387814214e-08 0.983943445516387 0.545112781954887 27.1 27 1 increased circulating triglyceride level 2.70318501710437e-06 6.37362344080296e-05 0.98342865940934 0.544827586206897 27.1 27 1 increased blood urea nitrogen level 2.70318501710437e-06 6.37362344080296e-05 0.98342865940934 0.544827586206897 27.1 27 1 increased total body fat amount 6.37547448447269e-06 0.000135546946838682 0.983335760423943 0.544776119402985 27.1 27 1 hunched posture 0.00048964520729842 0.005799964062642 0.982483206444037 0.544303797468354 27.1 27 1 abnormal sleep pattern 0.00723872927647063 0.0492054019052724 0.980993090357418 0.543478260869565 27.1 27 1 increased or absent threshold for auditory brainstem response 6.10458525834164e-11 3.65907369400598e-09 0.980585757586335 0.543252595155709 27.1 27 1 abnormal skeleton development 0.000448758269329698 0.00539268693216244 0.980508649325142 0.54320987654321 27.1 27 1 abnormal midbrain development 0.0184274892122638 0.100412660274931 0.979871955397009 0.542857142857143 27.1 27 1 abnormal thoracic vertebrae morphology 0.00265842736795229 0.0225025142211633 0.97899785017364 0.542372881355932 27.1 27 1 abnormal digit morphology 0.000994482568159596 0.0100296137821439 0.97772311338956 0.541666666666667 27.1 27 1 oligodactyly 0.00659624200772573 0.0468804342691936 0.97772311338956 0.541666666666667 27.1 27 1 abnormal digestive system morphology 0.0487929152678391 0.194662993951483 0.97772311338956 0.541666666666667 27.1 27 1 abnormal adrenal gland morphology 0.0487929152678391 0.194662993951483 0.97772311338956 0.541666666666667 27.1 27 1 abnormal vasodilation 0.0487929152678391 0.194662993951483 0.97772311338956 0.541666666666667 27.1 27 1 blindness 0.0487929152678391 0.194662993951483 0.97772311338956 0.541666666666667 27.1 27 1 abnormal sensory capabilities/reflexes/nociception 0.0487929152678391 0.194662993951483 0.97772311338956 0.541666666666667 27.1 27 1 abnormal cardiac muscle contractility 0.0487929152678391 0.194662993951483 0.97772311338956 0.541666666666667 27.1 27 1 abnormal impulse conducting system conduction 0.0487929152678391 0.194662993951483 0.97772311338956 0.541666666666667 27.1 27 1 decreased ovulation rate 0.0487929152678391 0.194662993951483 0.97772311338956 0.541666666666667 27.1 27 1 increased body temperature 0.0487929152678391 0.194662993951483 0.97772311338956 0.541666666666667 27.1 27 1 abnormal vertebrae morphology 6.03814878435055e-05 0.000978494794858111 0.977033118249553 0.541284403669725 27.1 27 1 increased white adipose tissue amount 0.016720748377906 0.0917152405513588 0.975690425004134 0.540540540540541 27.1 27 1 abnormal branching of the mammary ductal tree 0.016720748377906 0.0917152405513588 0.975690425004134 0.540540540540541 27.1 27 1 increased erythroid progenitor cell number 0.016720748377906 0.0917152405513588 0.975690425004134 0.540540540540541 27.1 27 1 increased trabecular bone volume 0.016720748377906 0.0917152405513588 0.975690425004134 0.540540540540541 27.1 27 1 small ovary 0.00028930672713969 0.00363459840282817 0.971937769523349 0.538461538461538 27.1 27 1 abnormal snout morphology 0.00547506201442674 0.0406865127186406 0.971937769523349 0.538461538461538 27.1 27 1 abnormal nasal bone morphology 0.0439264486263402 0.184736475360005 0.971937769523349 0.538461538461538 27.1 27 1 abnormal xiphoid process morphology 0.0439264486263402 0.184736475360005 0.971937769523349 0.538461538461538 27.1 27 1 increased susceptibility to otitis media 0.0439264486263402 0.184736475360005 0.971937769523349 0.538461538461538 27.1 27 1 increased leukemia incidence 0.0439264486263402 0.184736475360005 0.971937769523349 0.538461538461538 27.1 27 1 absent common myeloid progenitor cells 0.140531571098309 0.361688859914168 0.971937769523349 0.538461538461538 27.1 27 1 abnormal renal/urinary system morphology 0.140531571098309 0.361688859914168 0.971937769523349 0.538461538461538 27.1 27 1 increased foot pad pigmentation 0.140531571098309 0.361688859914168 0.971937769523349 0.538461538461538 27.1 27 1 abnormal sympathetic ganglion morphology 0.140531571098309 0.361688859914168 0.971937769523349 0.538461538461538 27.1 27 1 tight skin 0.140531571098309 0.361688859914168 0.971937769523349 0.538461538461538 27.1 27 1 increased pituitary adenoma incidence 0.140531571098309 0.361688859914168 0.971937769523349 0.538461538461538 27.1 27 1 lymphoid hypoplasia 0.140531571098309 0.361688859914168 0.971937769523349 0.538461538461538 27.1 27 1 abnormal lung interstitium morphology 0.140531571098309 0.361688859914168 0.971937769523349 0.538461538461538 27.1 27 1 dystrophic cardiac calcinosis 0.140531571098309 0.361688859914168 0.971937769523349 0.538461538461538 27.1 27 1 abnormal bile duct development 0.140531571098309 0.361688859914168 0.971937769523349 0.538461538461538 27.1 27 1 abnormal telomere length 0.140531571098309 0.361688859914168 0.971937769523349 0.538461538461538 27.1 27 1 small interparietal bone 0.140531571098309 0.361688859914168 0.971937769523349 0.538461538461538 27.1 27 1 decreased endocochlear potential 0.140531571098309 0.361688859914168 0.971937769523349 0.538461538461538 27.1 27 1 small pituitary gland 0.140531571098309 0.361688859914168 0.971937769523349 0.538461538461538 27.1 27 1 increased circulating thyroxine level 0.140531571098309 0.361688859914168 0.971937769523349 0.538461538461538 27.1 27 1 increased prostaglandin level 0.140531571098309 0.361688859914168 0.971937769523349 0.538461538461538 27.1 27 1 abnormal heart ventricle morphology 0.000761244821052233 0.0081796824724295 0.971937769523349 0.538461538461538 27.1 27 1 decreased bone mineral density 1.10045856689523e-09 5.31532171874154e-08 0.970371811785127 0.537593984962406 27.1 27 1 no abnormal phenotype detected 4.45053745061866e-56 5.53535595420696e-53 0.969616962992581 0.537175792507205 27.1 27 1 abnormal ovulation 0.0395689269554401 0.174146121690467 0.966978903352312 0.535714285714286 27.1 27 1 increased triglyceride level 0.0395689269554401 0.174146121690467 0.966978903352312 0.535714285714286 27.1 27 1 corneal vascularization 0.0395689269554401 0.174146121690467 0.966978903352312 0.535714285714286 27.1 27 1 prolonged QRS complex duration 0.0395689269554401 0.174146121690467 0.966978903352312 0.535714285714286 27.1 27 1 abnormal enzyme/coenzyme activity 3.51545651126702e-06 7.94972551979702e-05 0.965747083093264 0.535031847133758 27.1 27 1 abnormal vasculogenesis 0.0124953189010595 0.0764066599841289 0.965479711254091 0.534883720930233 27.1 27 1 abnormal pulmonary alveolus morphology 0.000185827208330476 0.00250539393345289 0.965064093642703 0.534653465346535 27.1 27 1 abnormal enzyme/coenzyme level 0.00413789577295333 0.0318176684241775 0.964755963344605 0.53448275862069 27.1 27 1 abnormal suckling behavior 0.000486295599472235 0.00577403486246866 0.964048664251244 0.534090909090909 27.1 27 1 increased T cell number 0.000486295599472235 0.00577403486246866 0.964048664251244 0.534090909090909 27.1 27 1 abnormal cardiovascular system physiology 2.12594790729031e-05 0.00039485060578674 0.963585994919497 0.533834586466165 27.1 27 1 abnormal brain vasculature morphology 0.035664398425225 0.160861633876241 0.962681219337413 0.533333333333333 27.1 27 1 decreased chondrocyte number 0.124056387485411 0.344555928388158 0.962681219337413 0.533333333333333 27.1 27 1 decreased salivation 0.124056387485411 0.344555928388158 0.962681219337413 0.533333333333333 27.1 27 1 hyperpigmentation 0.124056387485411 0.344555928388158 0.962681219337413 0.533333333333333 27.1 27 1 absent egg cylinders 0.124056387485411 0.344555928388158 0.962681219337413 0.533333333333333 27.1 27 1 abnormal bronchus morphology 0.124056387485411 0.344555928388158 0.962681219337413 0.533333333333333 27.1 27 1 abnormal ear development 0.124056387485411 0.344555928388158 0.962681219337413 0.533333333333333 27.1 27 1 abnormal secondary palate development 0.124056387485411 0.344555928388158 0.962681219337413 0.533333333333333 27.1 27 1 abnormal branching involved in lung morphogenesis 0.124056387485411 0.344555928388158 0.962681219337413 0.533333333333333 27.1 27 1 abnormal ovarian follicle morphology 0.0113411519580279 0.0713302540975841 0.962681219337412 0.533333333333333 27.1 27 1 abnormal ectoderm development 0.0113411519580279 0.0713302540975841 0.962681219337412 0.533333333333333 27.1 27 1 delayed bone ossification 0.00128402758142901 0.0124523142643457 0.962681219337412 0.533333333333333 27.1 27 1 increased T cell proliferation 0.000142308678776838 0.00199432585046414 0.961556591744729 0.532710280373832 27.1 27 1 neonatal lethality 0.0321631559963878 0.145862990959006 0.958920745824376 0.53125 27.1 27 1 impaired swimming 0.00284780553369722 0.0238917917877634 0.957211439682086 0.53030303030303 27.1 27 1 abnormal retinal photoreceptor morphology 0.0290211611920465 0.132702460413999 0.955602680959932 0.529411764705882 27.1 27 1 abnormal spleen red pulp morphology 0.0290211611920465 0.132702460413999 0.955602680959932 0.529411764705882 27.1 27 1 abnormal vagus nerve morphology 0.10988287961781 0.344555928388158 0.955602680959932 0.529411764705882 27.1 27 1 abnormal heart rate 0.10988287961781 0.344555928388158 0.955602680959932 0.529411764705882 27.1 27 1 abnormal testis development 0.10988287961781 0.344555928388158 0.955602680959932 0.529411764705882 27.1 27 1 decreased growth hormone level 0.10988287961781 0.344555928388158 0.955602680959932 0.529411764705882 27.1 27 1 pancytopenia 0.10988287961781 0.344555928388158 0.955602680959932 0.529411764705882 27.1 27 1 common atrium 0.10988287961781 0.344555928388158 0.955602680959932 0.529411764705882 27.1 27 1 delayed heart development 0.10988287961781 0.344555928388158 0.955602680959932 0.529411764705882 27.1 27 1 decreased body fat mass 0.10988287961781 0.344555928388158 0.955602680959932 0.529411764705882 27.1 27 1 kinked tail 0.000258809667373594 0.00337062328582103 0.955602680959931 0.529411764705882 27.1 27 1 increased kidney weight 0.00848614039215463 0.056593228486554 0.955602680959931 0.529411764705882 27.1 27 1 cataract 7.61754698088992e-05 0.00118429050718523 0.954725176202393 0.528925619834711 27.1 27 1 short limbs 0.000741784026126974 0.00798782582247121 0.954382243308642 0.528735632183908 27.1 27 1 abnormal uterus morphology 0.0261994391578039 0.129436156713083 0.952653289969314 0.527777777777778 27.1 27 1 abnormal reflex 0.0261994391578039 0.129436156713083 0.952653289969314 0.527777777777778 27.1 27 1 abnormal B cell differentiation 0.000617691994571444 0.00687475989483878 0.952102304839199 0.527472527472527 27.1 27 1 decreased circulating calcium level 0.00699908851858534 0.0485102459394288 0.95174166002676 0.527272727272727 27.1 27 1 abnormal angiogenesis 0.00196048503339434 0.0173240018492661 0.951298164379031 0.527027027027027 27.1 27 1 abnormal neuron differentiation 0.000164730838346101 0.00226391138334766 0.95086258829644 0.526785714285714 27.1 27 1 increased bone marrow cell number 0.0236634994053221 0.123803330028434 0.950014361188236 0.526315789473684 27.1 27 1 abnormal reproductive system physiology 0.0236634994053221 0.123803330028434 0.950014361188236 0.526315789473684 27.1 27 1 abnormal triglyceride level 0.0975992991798432 0.316942893877102 0.950014361188236 0.526315789473684 27.1 27 1 irregular coat pigmentation 0.0975992991798432 0.316942893877102 0.950014361188236 0.526315789473684 27.1 27 1 flaky skin 0.0975992991798432 0.316942893877102 0.950014361188236 0.526315789473684 27.1 27 1 abnormal long term depression 0.0975992991798432 0.316942893877102 0.950014361188236 0.526315789473684 27.1 27 1 decreased chemically-elicited antinociception 0.0975992991798432 0.316942893877102 0.950014361188236 0.526315789473684 27.1 27 1 abnormal neurotransmitter level 0.0975992991798432 0.316942893877102 0.950014361188236 0.526315789473684 27.1 27 1 abnormal neural crest cell migration 0.0975992991798432 0.316942893877102 0.950014361188236 0.526315789473684 27.1 27 1 abnormal metatarsal bone morphology 0.0975992991798432 0.316942893877102 0.950014361188236 0.526315789473684 27.1 27 1 abnormal response to novelty 0.0975992991798432 0.316942893877102 0.950014361188236 0.526315789473684 27.1 27 1 abnormal digestive system development 0.0975992991798432 0.316942893877102 0.950014361188236 0.526315789473684 27.1 27 1 increased left ventricle weight 0.0975992991798432 0.316942893877102 0.950014361188236 0.526315789473684 27.1 27 1 eyelids fail to open 0.0975992991798432 0.316942893877102 0.950014361188236 0.526315789473684 27.1 27 1 respiratory distress 3.63708822515692e-06 8.15068194601608e-05 0.949465219938994 0.526011560693642 27.1 27 1 increased hemoglobin content 0.00577587864991876 0.0421952955702582 0.948404167355714 0.525423728813559 27.1 27 1 liver inflammation 0.000114720578480385 0.00166395008145748 0.947639325285266 0.525 27.1 27 1 abnormal female reproductive system morphology 0.0213828049118202 0.113653263286651 0.947639325285265 0.525 27.1 27 1 perinatal lethality 0.0213828049118202 0.113653263286651 0.947639325285265 0.525 27.1 27 1 abnormal scapula morphology 0.0868911309208439 0.289734166441822 0.945490483277816 0.523809523809524 27.1 27 1 abnormal anxiety-related response 0.0868911309208439 0.289734166441822 0.945490483277816 0.523809523809524 27.1 27 1 trunk curl 0.0868911309208439 0.289734166441822 0.945490483277816 0.523809523809524 27.1 27 1 abnormal erythrocyte physiology 0.0868911309208439 0.289734166441822 0.945490483277816 0.523809523809524 27.1 27 1 vascular ring 0.0868911309208439 0.289734166441822 0.945490483277816 0.523809523809524 27.1 27 1 decreased vocalization 0.0868911309208439 0.289734166441822 0.945490483277816 0.523809523809524 27.1 27 1 decreased lymphocyte cell number 7.98781112798974e-05 0.00121381860790841 0.944818970150488 0.5234375 27.1 27 1 abnormal spleen morphology 4.96821115504194e-06 0.000108407239019007 0.944008523272678 0.522988505747126 27.1 27 1 abnormal myelopoiesis 0.0174819733438719 0.0956796670910482 0.943536990543771 0.522727272727273 27.1 27 1 abnormal photoreceptor outer segment morphology 0.0174819733438719 0.0956796670910482 0.943536990543771 0.522727272727273 27.1 27 1 increased spleen weight 0.000225722269336001 0.00300258901055242 0.942447875125675 0.52212389380531 27.1 27 1 abnormal blood vessel physiology 0.0775117579568222 0.264123969750131 0.941753366743121 0.521739130434783 27.1 27 1 abnormal innervation pattern to muscle 0.0775117579568222 0.264123969750131 0.941753366743121 0.521739130434783 27.1 27 1 abnormal cranial nerve morphology 0.0775117579568222 0.264123969750131 0.941753366743121 0.521739130434783 27.1 27 1 increased susceptibility to age related obesity 0.0775117579568222 0.264123969750131 0.941753366743121 0.521739130434783 27.1 27 1 abnormal B cell morphology 0.0775117579568222 0.264123969750131 0.941753366743121 0.521739130434783 27.1 27 1 abnormal basicranium morphology 0.0775117579568222 0.264123969750131 0.941753366743121 0.521739130434783 27.1 27 1 decreased effector memory CD8-positive, alpha-beta T cell number 0.0775117579568222 0.264123969750131 0.941753366743121 0.521739130434783 27.1 27 1 mandible hypoplasia 0.0692637741096266 0.23996328425863 0.938614188853977 0.52 27.1 27 1 diaphragmatic hernia 0.0692637741096266 0.23996328425863 0.938614188853977 0.52 27.1 27 1 abnormal vertebrae development 0.0692637741096266 0.23996328425863 0.938614188853977 0.52 27.1 27 1 abnormal cochlea morphology 0.010634312429092 0.0674817657330772 0.935940074355818 0.518518518518518 27.1 27 1 diluted coat color 0.010634312429092 0.0674817657330772 0.935940074355818 0.518518518518518 27.1 27 1 abnormal maxilla morphology 0.010634312429092 0.0674817657330772 0.935940074355818 0.518518518518518 27.1 27 1 polyphagia 0.010634312429092 0.0674817657330772 0.935940074355818 0.518518518518518 27.1 27 1 abnormal type II pneumocyte morphology 0.0619865246876762 0.21871131937673 0.935940074355818 0.518518518518518 27.1 27 1 decreased bone ossification 0.0619865246876762 0.21871131937673 0.935940074355818 0.518518518518518 27.1 27 1 abnormal lipid level 0.00184463862801766 0.0168568333535414 0.935134618181673 0.518072289156627 27.1 27 1 abnormal eye development 0.00963718721009002 0.0635875416050369 0.934746273240568 0.517857142857143 27.1 27 1 cardiac fibrosis 0.00167856301809951 0.0156676379269138 0.934367065827489 0.517647058823529 27.1 27 1 glomerulosclerosis 0.00873603305008452 0.0580263877492263 0.933634803236715 0.517241379310345 27.1 27 1 aphagia 0.0555474837530214 0.21083722131187 0.933634803236715 0.517241379310345 27.1 27 1 decreased bone strength 0.0555474837530214 0.21083722131187 0.933634803236715 0.517241379310345 27.1 27 1 polychromatophilia 0.0555474837530214 0.21083722131187 0.933634803236715 0.517241379310345 27.1 27 1 absent mature ovarian follicles 0.0498360977038261 0.198189117567174 0.93162698645556 0.516129032258065 27.1 27 1 abnormal nose morphology 0.0498360977038261 0.198189117567174 0.93162698645556 0.516129032258065 27.1 27 1 inner cell mass degeneration 0.0498360977038261 0.198189117567174 0.93162698645556 0.516129032258065 27.1 27 1 decreased neuronal precursor cell number 0.0498360977038261 0.198189117567174 0.93162698645556 0.516129032258065 27.1 27 1 abnormal osteoclast physiology 0.00651759182408187 0.0464541824137641 0.9307171944766 0.515625 27.1 27 1 decreased eosinophil cell number 0.00651759182408187 0.0464541824137641 0.9307171944766 0.515625 27.1 27 1 abnormal lipid homeostasis 0.000146621941271787 0.00203824236304556 0.930283293686634 0.515384615384615 27.1 27 1 insulin resistance 0.000133740621212321 0.00190647447143638 0.929862541405455 0.515151515151515 27.1 27 1 enlarged pericardium 0.0447592724806581 0.184736475360005 0.929862541405455 0.515151515151515 27.1 27 1 abnormal skeleton physiology 0.0447592724806581 0.184736475360005 0.929862541405455 0.515151515151515 27.1 27 1 head tossing 0.0447592724806581 0.184736475360005 0.929862541405455 0.515151515151515 27.1 27 1 increased red blood cell distribution width 0.0402379903471105 0.176373570023678 0.928299747218219 0.514285714285714 27.1 27 1 decreased bone volume 0.0402379903471105 0.176373570023678 0.928299747218219 0.514285714285714 27.1 27 1 decreased hematocrit 7.03341696181404e-05 0.00111083331381031 0.927240044310436 0.513698630136986 27.1 27 1 abnormal chromosome morphology 0.0362047238699182 0.161831537513786 0.926905903753928 0.513513513513513 27.1 27 1 decreased neutrophil cell number 0.000375639776767189 0.00461434046769572 0.925655018593666 0.512820512820513 27.1 27 1 increased rib number 0.00331577513624927 0.0274019622970766 0.925655018593666 0.512820512820513 27.1 27 1 small lens 0.0326014257117613 0.147715931617497 0.925655018593666 0.512820512820513 27.1 27 1 scaly skin 0.0293779428848157 0.134087399864182 0.924526171010015 0.51219512195122 27.1 27 1 short humerus 0.0293779428848157 0.134087399864182 0.924526171010015 0.51219512195122 27.1 27 1 abnormal male reproductive system morphology 0.0264907495817196 0.130745515048666 0.923502332503913 0.511627906976744 27.1 27 1 abnormal autopod morphology 0.023901922974527 0.123803330028434 0.92256950186502 0.511111111111111 27.1 27 1 increased sarcoma incidence 0.0194908233862532 0.105513434544733 0.920932288906964 0.510204081632653 27.1 27 1 impaired hematopoiesis 0.0176138996331123 0.0962957699722348 0.920209989072527 0.509803921568627 27.1 27 1 abnormal mesoderm development 0.0159249903228395 0.0891623009134181 0.919542202433142 0.509433962264151 27.1 27 1 enlarged kidney 0.0159249903228395 0.0891623009134181 0.919542202433142 0.509433962264151 27.1 27 1 decreased T cell number 4.92735857209641e-05 0.00080636871369012 0.919330667534951 0.509316770186335 27.1 27 1 increased circulating calcium level 0.0144041742622099 0.0840102777895593 0.918922982094803 0.509090909090909 27.1 27 1 abnormal craniofacial bone morphology 0.0130338132742732 0.0791736520628927 0.918347215815295 0.508771929824561 27.1 27 1 maternal effect 0.00794800033269535 0.0531469108268271 0.915983996011344 0.507462686567164 27.1 27 1 hyperkeratosis 0.0072059703765381 0.0492054019052724 0.915593551000256 0.507246376811594 27.1 27 1 atelectasis 0.00653496843094153 0.0465113990614222 0.915225102891202 0.507042253521127 27.1 27 1 spleen hyperplasia 0.00537863265233231 0.040605003710703 0.914547158370542 0.506666666666667 27.1 27 1 abnormal limb morphology 0.00537863265233231 0.040605003710703 0.914547158370542 0.506666666666667 27.1 27 1 abnormal visceral yolk sac morphology 0.00443099404437829 0.0338620512608018 0.913937866459569 0.506329113924051 27.1 27 1 spleen hypoplasia 0.00127948430896469 0.0124324891349597 0.911109011158623 0.504761904761905 27.1 27 1 abnormal long bone epiphyseal plate morphology 0.0156752430995725 0.0891623009134181 0.902513643128824 0.5 27.1 27 1 abnormal eye physiology 0.0156752430995725 0.0891623009134181 0.902513643128824 0.5 27.1 27 1 abnormal long bone epiphyseal plate proliferative zone 0.0212156682165871 0.113006369783213 0.902513643128824 0.5 27.1 27 1 abnormal osteoblast physiology 0.0212156682165871 0.113006369783213 0.902513643128824 0.5 27.1 27 1 increased dopamine level 0.0675090394112643 0.235029720833478 0.902513643128824 0.5 27.1 27 1 abnormal lumbar vertebrae morphology 0.0675090394112643 0.235029720833478 0.902513643128824 0.5 27.1 27 1 abnormal hair cycle 0.0754305690808182 0.258983492875825 0.902513643128824 0.5 27.1 27 1 abnormal spleen marginal zone morphology 0.0754305690808182 0.258983492875825 0.902513643128824 0.5 27.1 27 1 abnormal bone marrow cell number 0.17341909339899 0.433765706214166 0.902513643128824 0.5 27.1 27 1 abnormal meiosis 0.17341909339899 0.433765706214166 0.902513643128824 0.5 27.1 27 1 abnormal epicardium morphology 0.17341909339899 0.433765706214166 0.902513643128824 0.5 27.1 27 1 abnormal pulmonary elastic fiber morphology 0.17341909339899 0.433765706214166 0.902513643128824 0.5 27.1 27 1 large intestinal inflammation 0.17341909339899 0.433765706214166 0.902513643128824 0.5 27.1 27 1 small pancreas 0.17341909339899 0.433765706214166 0.902513643128824 0.5 27.1 27 1 small epididymis 0.17341909339899 0.433765706214166 0.902513643128824 0.5 27.1 27 1 decreased circulating prolactin level 0.17341909339899 0.433765706214166 0.902513643128824 0.5 27.1 27 1 abnormal thoracic cage shape 0.17341909339899 0.433765706214166 0.902513643128824 0.5 27.1 27 1 abnormal pulmonary alveolus wall morphology 0.17341909339899 0.433765706214166 0.902513643128824 0.5 27.1 27 1 decreased adipocyte glucose uptake 0.17341909339899 0.433765706214166 0.902513643128824 0.5 27.1 27 1 decreased B cell number 1.61867351271654e-05 0.000307362623120793 0.902513643128824 0.5 27.1 27 1 improved glucose tolerance 2.5598810016832e-05 0.000459762021060431 0.902513643128824 0.5 27.1 27 1 increased monocyte cell number 0.00223527155221264 0.0194074624297695 0.902513643128824 0.5 27.1 27 1 abnormal developmental patterning 0.00530797066657953 0.0401935373915269 0.902513643128824 0.5 27.1 27 1 short mandible 0.0191711613143296 0.104350686585109 0.902513643128824 0.5 27.1 27 1 kidney inflammation 0.0260211145955686 0.129165617057849 0.902513643128824 0.5 27.1 27 1 abnormal spleen white pulp morphology 0.0394255890942958 0.174146121690467 0.902513643128824 0.5 27.1 27 1 abnormal frontal bone morphology 0.0487459483345146 0.194662993951483 0.902513643128824 0.5 27.1 27 1 abnormal compact bone morphology 0.0487459483345146 0.194662993951483 0.902513643128824 0.5 27.1 27 1 abnormal limb bone morphology 0.0542765415364169 0.21083722131187 0.902513643128824 0.5 27.1 27 1 increased susceptibility to weight gain 0.0604973837692694 0.213912213398803 0.902513643128824 0.5 27.1 27 1 failure of blastocyst to hatch from the zona pellucida 0.0844041224199119 0.282768019554924 0.902513643128824 0.5 27.1 27 1 abnormal hormone level 0.0844041224199119 0.282768019554924 0.902513643128824 0.5 27.1 27 1 abnormal renal tubule epithelium morphology 0.0844041224199119 0.282768019554924 0.902513643128824 0.5 27.1 27 1 abnormal stomach morphology 0.0946010995929126 0.309631888470224 0.902513643128824 0.5 27.1 27 1 small seminal vesicle 0.0946010995929126 0.309631888470224 0.902513643128824 0.5 27.1 27 1 no spontaneous movement 0.0946010995929126 0.309631888470224 0.902513643128824 0.5 27.1 27 1 abnormal ocular fundus morphology 0.0946010995929126 0.309631888470224 0.902513643128824 0.5 27.1 27 1 abnormal facial nerve morphology 0.119551309867666 0.344555928388158 0.902513643128824 0.5 27.1 27 1 increased myocardial infarction size 0.119551309867666 0.344555928388158 0.902513643128824 0.5 27.1 27 1 abnormal retinal layer morphology 0.119551309867666 0.344555928388158 0.902513643128824 0.5 27.1 27 1 abnormal basement membrane morphology 0.119551309867666 0.344555928388158 0.902513643128824 0.5 27.1 27 1 decreased circulating estradiol level 0.119551309867666 0.344555928388158 0.902513643128824 0.5 27.1 27 1 abnormal cell proliferation 0.134888713380039 0.350428902906368 0.902513643128824 0.5 27.1 27 1 abnormal dopamine level 0.134888713380039 0.350428902906368 0.902513643128824 0.5 27.1 27 1 abnormal male reproductive system physiology 0.134888713380039 0.350428902906368 0.902513643128824 0.5 27.1 27 1 abnormal heart right ventricle morphology 0.134888713380039 0.350428902906368 0.902513643128824 0.5 27.1 27 1 decreased circulating VLDL cholesterol level 0.134888713380039 0.350428902906368 0.902513643128824 0.5 27.1 27 1 decreased muscle cell glucose uptake 0.134888713380039 0.350428902906368 0.902513643128824 0.5 27.1 27 1 cortical renal glomerulopathies 0.15266092792612 0.391085538842661 0.902513643128824 0.5 27.1 27 1 abnormal Peyer's patch follicle morphology 0.15266092792612 0.391085538842661 0.902513643128824 0.5 27.1 27 1 absent allantois 0.15266092792612 0.391085538842661 0.902513643128824 0.5 27.1 27 1 abnormal glycogen homeostasis 0.15266092792612 0.391085538842661 0.902513643128824 0.5 27.1 27 1 megacephaly 0.197913809832222 0.480772072224269 0.902513643128824 0.5 27.1 27 1 abnormal kidney blood vessel morphology 0.197913809832222 0.480772072224269 0.902513643128824 0.5 27.1 27 1 abnormal placing response 0.197913809832222 0.480772072224269 0.902513643128824 0.5 27.1 27 1 absent visceral yolk sac blood islands 0.197913809832222 0.480772072224269 0.902513643128824 0.5 27.1 27 1 abnormal antigen presentation 0.197913809832222 0.480772072224269 0.902513643128824 0.5 27.1 27 1 failure of zygotic cell division 0.197913809832222 0.480772072224269 0.902513643128824 0.5 27.1 27 1 vascular smooth muscle hypoplasia 0.197913809832222 0.480772072224269 0.902513643128824 0.5 27.1 27 1 abnormal decidualization 0.197913809832222 0.480772072224269 0.902513643128824 0.5 27.1 27 1 abnormal pancreas development 0.197913809832222 0.480772072224269 0.902513643128824 0.5 27.1 27 1 split sternum 0.197913809832222 0.480772072224269 0.902513643128824 0.5 27.1 27 1 increased circulating growth hormone level 0.197913809832222 0.480772072224269 0.902513643128824 0.5 27.1 27 1 decreased tongue size 0.197913809832222 0.480772072224269 0.902513643128824 0.5 27.1 27 1 abnormal renal tubule epithelial cell primary cilium morphology 0.197913809832222 0.480772072224269 0.902513643128824 0.5 27.1 27 1 abnormal auchene hair morphology 0.262914665526115 0.581333538218853 0.902513643128824 0.5 27.1 27 1 jaundice 0.262914665526115 0.581333538218853 0.902513643128824 0.5 27.1 27 1 abnormal grooming behavior 0.262914665526115 0.581333538218853 0.902513643128824 0.5 27.1 27 1 rhinitis 0.262914665526115 0.581333538218853 0.902513643128824 0.5 27.1 27 1 abnormal bone healing 0.262914665526115 0.581333538218853 0.902513643128824 0.5 27.1 27 1 abnormal scala media morphology 0.262914665526115 0.581333538218853 0.902513643128824 0.5 27.1 27 1 abnormal hypaxial muscle morphology 0.262914665526115 0.581333538218853 0.902513643128824 0.5 27.1 27 1 increased atrioventricular cushion size 0.262914665526115 0.581333538218853 0.902513643128824 0.5 27.1 27 1 increased left ventricle diastolic pressure 0.262914665526115 0.581333538218853 0.902513643128824 0.5 27.1 27 1 abnormal reproductive system development 0.262914665526115 0.581333538218853 0.902513643128824 0.5 27.1 27 1 abnormal plasma membrane morphology 0.262914665526115 0.581333538218853 0.902513643128824 0.5 27.1 27 1 abnormal respiratory conducting tube morphology 0.262914665526115 0.581333538218853 0.902513643128824 0.5 27.1 27 1 decreased cochlear inner hair cell number 0.262914665526115 0.581333538218853 0.902513643128824 0.5 27.1 27 1 increased susceptibility to atherosclerosis 0.262914665526115 0.581333538218853 0.902513643128824 0.5 27.1 27 1 vascular smooth muscle hyperplasia 0.262914665526115 0.581333538218853 0.902513643128824 0.5 27.1 27 1 absent axillary lymph nodes 0.262914665526115 0.581333538218853 0.902513643128824 0.5 27.1 27 1 impaired behavioral response to morphine 0.262914665526115 0.581333538218853 0.902513643128824 0.5 27.1 27 1 abnormal sperm principal piece morphology 0.262914665526115 0.581333538218853 0.902513643128824 0.5 27.1 27 1 abnormal retinal blood vessel pattern 0.262914665526115 0.581333538218853 0.902513643128824 0.5 27.1 27 1 abnormal heart and great artery attachment 0.262914665526115 0.581333538218853 0.902513643128824 0.5 27.1 27 1 common ventricle 0.262914665526115 0.581333538218853 0.902513643128824 0.5 27.1 27 1 sinus bradycardia 0.262914665526115 0.581333538218853 0.902513643128824 0.5 27.1 27 1 decreased macrophage apoptosis 0.262914665526115 0.581333538218853 0.902513643128824 0.5 27.1 27 1 abnormal phalanx morphology 0.0288416178469484 0.132287475754227 0.902513643128824 0.5 27.1 27 1 abnormal body weight 0.106230600645806 0.338130030846374 0.902513643128824 0.5 27.1 27 1 abnormal primitive streak formation 0.106230600645806 0.338130030846374 0.902513643128824 0.5 27.1 27 1 prolonged QT interval 0.106230600645806 0.338130030846374 0.902513643128824 0.5 27.1 27 1 abnormal esophagus morphology 0.227211455051499 0.533700183607746 0.902513643128824 0.5 27.1 27 1 impaired sperm capacitation 0.227211455051499 0.533700183607746 0.902513643128824 0.5 27.1 27 1 delayed somite formation 0.227211455051499 0.533700183607746 0.902513643128824 0.5 27.1 27 1 increased hepatocyte proliferation 0.227211455051499 0.533700183607746 0.902513643128824 0.5 27.1 27 1 stria vascularis degeneration 0.227211455051499 0.533700183607746 0.902513643128824 0.5 27.1 27 1 hematuria 0.227211455051499 0.533700183607746 0.902513643128824 0.5 27.1 27 1 abnormal anogenital distance 0.227211455051499 0.533700183607746 0.902513643128824 0.5 27.1 27 1 abnormal palatine bone morphology 0.227211455051499 0.533700183607746 0.902513643128824 0.5 27.1 27 1 abnormal thymus corticomedullary boundary morphology 0.227211455051499 0.533700183607746 0.902513643128824 0.5 27.1 27 1 abnormal aorta elastic tissue morphology 0.227211455051499 0.533700183607746 0.902513643128824 0.5 27.1 27 1 increased fibrosarcoma incidence 0.227211455051499 0.533700183607746 0.902513643128824 0.5 27.1 27 1 abnormal kidney morphology 9.13477328105879e-05 0.00136064362494813 0.897356422310945 0.497142857142857 27.1 27 1 abnormal lung morphology 0.00123941730533852 0.0121619350967635 0.894929494867237 0.495798319327731 27.1 27 1 abnormal skeleton morphology 0.00149701682922868 0.014405529449541 0.894665698405965 0.495652173913044 27.1 27 1 absent vitelline blood vessels 0.0250968766633496 0.126245663700874 0.886680070442354 0.491228070175439 27.1 27 1 abnormal platelet physiology 0.0277838945297365 0.131547515031184 0.886104304162846 0.490909090909091 27.1 27 1 abnormal placenta development 0.0307742239107682 0.139691390470868 0.885485083824507 0.490566037735849 27.1 27 1 abnormal pancreatic islet morphology 0.0307742239107682 0.139691390470868 0.885485083824507 0.490566037735849 27.1 27 1 decreased circulating creatinine level 0.0378183805292158 0.168590002807212 0.884094997350685 0.489795918367347 27.1 27 1 increased fluid intake 0.0378183805292158 0.168590002807212 0.884094997350685 0.489795918367347 27.1 27 1 increased circulating glucose level 0.000802400307930833 0.00854805467228243 0.883311225189913 0.48936170212766 27.1 27 1 abnormal innervation 0.0419626315637288 0.183448235526846 0.883311225189913 0.48936170212766 27.1 27 1 decreased bone trabecula number 0.0419626315637288 0.183448235526846 0.883311225189913 0.48936170212766 27.1 27 1 hyperglycemia 0.00735669940855719 0.0495929262297724 0.882001969421351 0.488636363636364 27.1 27 1 abnormal organ of Corti morphology 0.0517724813563007 0.203772226857275 0.881524953753735 0.488372093023256 27.1 27 1 abnormal homeostasis 0.0517724813563007 0.203772226857275 0.881524953753735 0.488372093023256 27.1 27 1 arrested B cell differentiation 0.0575744309182609 0.21083722131187 0.880501115247633 0.48780487804878 27.1 27 1 hemopericardium 0.0575744309182609 0.21083722131187 0.880501115247633 0.48780487804878 27.1 27 1 palatal shelves fail to meet at midline 0.0575744309182609 0.21083722131187 0.880501115247633 0.48780487804878 27.1 27 1 decreased trabecular bone volume 0.0640832448261302 0.22562925903043 0.879372267663983 0.487179487179487 27.1 27 1 abnormal intestine morphology 0.0145598280538132 0.0848186704540053 0.878121382503721 0.486486486486487 27.1 27 1 decreased circulating chloride level 0.0713972109046792 0.246325328884035 0.878121382503721 0.486486486486487 27.1 27 1 abnormal pancreatic beta cell physiology 0.0713972109046792 0.246325328884035 0.878121382503721 0.486486486486487 27.1 27 1 skin inflammation 0.0713972109046792 0.246325328884035 0.878121382503721 0.486486486486487 27.1 27 1 abnormal humerus morphology 0.0713972109046792 0.246325328884035 0.878121382503721 0.486486486486487 27.1 27 1 cochlear outer hair cell degeneration 0.0160681472866023 0.0891623009134181 0.877443819708579 0.486111111111111 27.1 27 1 abnormal dendritic cell physiology 0.00396998356907216 0.0309959705165527 0.877209522293437 0.485981308411215 27.1 27 1 abnormal intestinal goblet cell morphology 0.0796312553346416 0.270975030978004 0.876727539039429 0.485714285714286 27.1 27 1 decreased circulating thyroxine level 0.0796312553346416 0.270975030978004 0.876727539039429 0.485714285714286 27.1 27 1 decreased systemic arterial blood pressure 0.0889205847577177 0.296104356873926 0.875164744852193 0.484848484848485 27.1 27 1 abnormal tooth morphology 0.0239114035224776 0.123803330028434 0.874310091781048 0.484375 27.1 27 1 alopecia 0.00703897545946703 0.0487050110025709 0.874013212293177 0.484210526315789 27.1 27 1 decreased litter size 7.23947144059442e-06 0.000150696110531202 0.873607512210107 0.483985765124555 27.1 27 1 abnormal CD8-positive, alpha beta T cell morphology 0.0994253859967483 0.322662293107517 0.873400299802088 0.483870967741935 27.1 27 1 abnormal microglial cell morphology 0.111336985175676 0.344555928388158 0.871392483020934 0.482758620689655 27.1 27 1 focal hair loss 0.111336985175676 0.344555928388158 0.871392483020934 0.482758620689655 27.1 27 1 abnormal CD8-positive, alpha-beta T cell physiology 0.111336985175676 0.344555928388158 0.871392483020934 0.482758620689655 27.1 27 1 increased leukocyte cell number 0.00117853505078627 0.0115873752522958 0.871392483020934 0.482758620689655 27.1 27 1 abnormal seminal vesicle morphology 0.0358026461440808 0.161338917180074 0.87028101301708 0.482142857142857 27.1 27 1 rectal prolapse 0.124886062004918 0.344555928388158 0.869087211901831 0.481481481481481 27.1 27 1 cryptorchism 0.124886062004918 0.344555928388158 0.869087211901831 0.481481481481481 27.1 27 1 abnormal palate morphology 0.124886062004918 0.344555928388158 0.869087211901831 0.481481481481481 27.1 27 1 increased circulating insulin level 0.00077727699062954 0.00831602801802572 0.868669381511493 0.48125 27.1 27 1 abnormal keratinocyte physiology 0.14035382514074 0.361688859914168 0.866413097403671 0.48 27.1 27 1 abnormal cardiovascular system morphology 0.0540339641831669 0.21083722131187 0.864908907998456 0.479166666666667 27.1 27 1 cleft secondary palate 0.00980499040350916 0.0637719076715565 0.864108807251002 0.478723404255319 27.1 27 1 abnormal forelimb morphology 0.0599813162265279 0.213189192096727 0.863273919514528 0.478260869565217 27.1 27 1 abnormal pulmonary artery morphology 0.15808756578594 0.403119241304485 0.863273919514528 0.478260869565217 27.1 27 1 abnormal circulating insulin level 0.15808756578594 0.403119241304485 0.863273919514528 0.478260869565217 27.1 27 1 abnormal postnatal growth 0.15808756578594 0.403119241304485 0.863273919514528 0.478260869565217 27.1 27 1 pancreas inflammation 0.15808756578594 0.403119241304485 0.863273919514528 0.478260869565217 27.1 27 1 abnormal lens development 0.15808756578594 0.403119241304485 0.863273919514528 0.478260869565217 27.1 27 1 abnormal palatal shelf fusion at midline 0.15808756578594 0.403119241304485 0.863273919514528 0.478260869565217 27.1 27 1 abnormal hepatocyte physiology 0.15808756578594 0.403119241304485 0.863273919514528 0.478260869565217 27.1 27 1 abnormal coat appearance 0.0249341558680546 0.125554074335599 0.863273919514527 0.478260869565217 27.1 27 1 decreased insulin secretion 0.0118773873286215 0.0745145043630419 0.862401925656432 0.477777777777778 27.1 27 1 osteoporosis 0.0666303972811442 0.233949919947275 0.861490295713878 0.477272727272727 27.1 27 1 decreased monocyte cell number 0.0304111432819678 0.138295647008948 0.860859167292109 0.476923076923077 27.1 27 1 increased food intake 0.0158567494325203 0.0891623009134181 0.859536802979833 0.476190476190476 27.1 27 1 skin lesions 0.0336028931827212 0.151700901618909 0.859536802979833 0.476190476190476 27.1 27 1 abnormal muscle morphology 0.0740733780309567 0.255381188984068 0.859536802979833 0.476190476190476 27.1 27 1 dry skin 0.178522879252035 0.445188633723746 0.859536802979833 0.476190476190476 27.1 27 1 increased double-negative T cell number 0.0371434452324792 0.165878491949357 0.858127726253636 0.475409836065574 27.1 27 1 abnormal skin pigmentation 0.0824166147296598 0.279505357103292 0.857387960972383 0.475 27.1 27 1 increased susceptibility to weight loss 0.0824166147296598 0.279505357103292 0.857387960972383 0.475 27.1 27 1 syndactyly 0.0410732425331962 0.179876216199517 0.856623118901935 0.474576271186441 27.1 27 1 weight loss 0.000873692007684403 0.00922848776694247 0.856098655767913 0.474285714285714 27.1 27 1 increased inflammatory response 0.0122944038531471 0.0764066599841289 0.855012925069413 0.473684210526316 27.1 27 1 abnormal retinal outer nuclear layer morphology 0.0917833472178276 0.303822524022245 0.855012925069412 0.473684210526316 27.1 27 1 shiny skin 0.20221639379777 0.487179931788817 0.855012925069412 0.473684210526316 27.1 27 1 thin dermal layer 0.20221639379777 0.487179931788817 0.855012925069412 0.473684210526316 27.1 27 1 short vibrissae 0.20221639379777 0.487179931788817 0.855012925069412 0.473684210526316 27.1 27 1 altered susceptibility to infection 0.20221639379777 0.487179931788817 0.855012925069412 0.473684210526316 27.1 27 1 abnormal nasal septum morphology 0.20221639379777 0.487179931788817 0.855012925069412 0.473684210526316 27.1 27 1 osteoarthritis 0.20221639379777 0.487179931788817 0.855012925069412 0.473684210526316 27.1 27 1 thin interventricular septum 0.20221639379777 0.487179931788817 0.855012925069412 0.473684210526316 27.1 27 1 increased sensitivity to xenobiotic induced morbidity/mortality 0.00791015210204212 0.0530363971801341 0.853285626230888 0.472727272727273 27.1 27 1 short radius 0.102317051890947 0.328008353091108 0.852373996288334 0.472222222222222 27.1 27 1 thin skin 0.114185652303005 0.344555928388158 0.849424605297717 0.470588235294118 27.1 27 1 abnormal urinary bladder morphology 0.229895727871151 0.536711049347243 0.849424605297717 0.470588235294118 27.1 27 1 distended urinary bladder 0.229895727871151 0.536711049347243 0.849424605297717 0.470588235294118 27.1 27 1 abnormal cranial suture morphology 0.229895727871151 0.536711049347243 0.849424605297717 0.470588235294118 27.1 27 1 abnormal duodenum morphology 0.229895727871151 0.536711049347243 0.849424605297717 0.470588235294118 27.1 27 1 aminoaciduria 0.229895727871151 0.536711049347243 0.849424605297717 0.470588235294118 27.1 27 1 increased regulatory T cell number 0.229895727871151 0.536711049347243 0.849424605297717 0.470588235294118 27.1 27 1 abnormal melanosome morphology 0.229895727871151 0.536711049347243 0.849424605297717 0.470588235294118 27.1 27 1 abnormal survival 0.229895727871151 0.536711049347243 0.849424605297717 0.470588235294118 27.1 27 1 cochlear inner hair cell degeneration 0.0616887772071451 0.217969933668712 0.849424605297717 0.470588235294118 27.1 27 1 organ of Corti degeneration 0.0683785189539696 0.237392276200976 0.847257705794406 0.469387755102041 27.1 27 1 abnormal long bone hypertrophic chondrocyte zone 0.0683785189539696 0.237392276200976 0.847257705794406 0.469387755102041 27.1 27 1 abnormal respiratory system physiology 0.0683785189539696 0.237392276200976 0.847257705794406 0.469387755102041 27.1 27 1 abnormal craniofacial development 0.0683785189539696 0.237392276200976 0.847257705794406 0.469387755102041 27.1 27 1 abnormal diaphragm morphology 0.127586868278058 0.3453995886473 0.846106540433273 0.46875 27.1 27 1 abnormal serotonin level 0.127586868278058 0.3453995886473 0.846106540433273 0.46875 27.1 27 1 hepatic necrosis 0.0758377587297905 0.26020196529704 0.844906389312091 0.468085106382979 27.1 27 1 abnormal renal glomerulus morphology 0.0107551553418473 0.0681616532811339 0.844554051368257 0.467889908256881 27.1 27 1 increased eosinophil cell number 0.0465550977644712 0.189690099408881 0.844286956475352 0.467741935483871 27.1 27 1 abnormal heart tube morphology 0.142755099258677 0.366842261783015 0.842346066920236 0.466666666666667 27.1 27 1 emphysema 0.142755099258677 0.366842261783015 0.842346066920236 0.466666666666667 27.1 27 1 abnormal fontanelle morphology 0.262539054385682 0.581333538218853 0.842346066920236 0.466666666666667 27.1 27 1 abnormal epidermis stratum spinosum morphology 0.262539054385682 0.581333538218853 0.842346066920236 0.466666666666667 27.1 27 1 no suckling reflex 0.262539054385682 0.581333538218853 0.842346066920236 0.466666666666667 27.1 27 1 placental labyrinth hypoplasia 0.262539054385682 0.581333538218853 0.842346066920236 0.466666666666667 27.1 27 1 arthritis 0.262539054385682 0.581333538218853 0.842346066920236 0.466666666666667 27.1 27 1 increased alcohol consumption 0.262539054385682 0.581333538218853 0.842346066920236 0.466666666666667 27.1 27 1 greasy coat 0.262539054385682 0.581333538218853 0.842346066920236 0.466666666666667 27.1 27 1 abnormal energy homeostasis 0.262539054385682 0.581333538218853 0.842346066920236 0.466666666666667 27.1 27 1 abnormal dendritic cell morphology 0.262539054385682 0.581333538218853 0.842346066920236 0.466666666666667 27.1 27 1 decreased thymocyte apoptosis 0.262539054385682 0.581333538218853 0.842346066920236 0.466666666666667 27.1 27 1 abnormal aorta wall morphology 0.262539054385682 0.581333538218853 0.842346066920236 0.466666666666667 27.1 27 1 liver vascular congestion 0.262539054385682 0.581333538218853 0.842346066920236 0.466666666666667 27.1 27 1 ostium primum atrial septal defect 0.262539054385682 0.581333538218853 0.842346066920236 0.466666666666667 27.1 27 1 albuminuria 0.0841632204723273 0.282722499560991 0.842346066920236 0.466666666666667 27.1 27 1 dermatitis 0.0568417366962987 0.21083722131187 0.840271322913043 0.46551724137931 27.1 27 1 abnormal CD4-positive, alpha-beta T cell physiology 0.0389629677549851 0.173536942328604 0.838956344316935 0.464788732394366 27.1 27 1 hydronephrosis 0.026983264859193 0.131547515031184 0.838048382905337 0.464285714285714 27.1 27 1 abnormal jaw morphology 0.159970409645256 0.403371914842955 0.838048382905337 0.464285714285714 27.1 27 1 reddish skin 0.159970409645256 0.403371914842955 0.838048382905337 0.464285714285714 27.1 27 1 abnormal food intake 0.0429480881083278 0.184736475360005 0.837114103771663 0.463768115942029 27.1 27 1 abnormal mandible morphology 0.0695058042293988 0.240634221323075 0.835660780674837 0.462962962962963 27.1 27 1 abnormal hair growth 0.0769072100056732 0.263507830425774 0.833089516734299 0.461538461538462 27.1 27 1 decreased body temperature 0.0769072100056732 0.263507830425774 0.833089516734299 0.461538461538462 27.1 27 1 abnormal Schwann cell morphology 0.179570447038878 0.447576640289789 0.833089516734299 0.461538461538462 27.1 27 1 absent myocardial trabeculae 0.301508498439947 0.588082919926276 0.833089516734299 0.461538461538462 27.1 27 1 short hair 0.301508498439947 0.588082919926276 0.833089516734299 0.461538461538462 27.1 27 1 uterus hypoplasia 0.301508498439947 0.588082919926276 0.833089516734299 0.461538461538462 27.1 27 1 pup cannibalization 0.301508498439947 0.588082919926276 0.833089516734299 0.461538461538462 27.1 27 1 abnormal grip strength 0.301508498439947 0.588082919926276 0.833089516734299 0.461538461538462 27.1 27 1 abnormal pulmonary alveolus epithelial cell morphology 0.301508498439947 0.588082919926276 0.833089516734299 0.461538461538462 27.1 27 1 anal atresia 0.301508498439947 0.588082919926276 0.833089516734299 0.461538461538462 27.1 27 1 abnormal GABAergic neuron morphology 0.301508498439947 0.588082919926276 0.833089516734299 0.461538461538462 27.1 27 1 abnormal insulin secretion 0.301508498439947 0.588082919926276 0.833089516734299 0.461538461538462 27.1 27 1 increased circulating ammonia level 0.301508498439947 0.588082919926276 0.833089516734299 0.461538461538462 27.1 27 1 abnormal hair follicle inner root sheath morphology 0.301508498439947 0.588082919926276 0.833089516734299 0.461538461538462 27.1 27 1 increased urine protein level 0.0359208416345531 0.161710388320524 0.833089516734299 0.461538461538462 27.1 27 1 acanthosis 0.115526292124996 0.344555928388158 0.833089516734299 0.461538461538462 27.1 27 1 impaired macrophage chemotaxis 0.115526292124996 0.344555928388158 0.833089516734299 0.461538461538462 27.1 27 1 decreased B-1 B cell number 0.115526292124996 0.344555928388158 0.833089516734299 0.461538461538462 27.1 27 1 abnormal hair follicle morphology 0.057602566378317 0.21083722131187 0.830885576213838 0.46031746031746 27.1 27 1 abnormal hindlimb morphology 0.0851347468494531 0.285023799176332 0.830312551678518 0.46 27.1 27 1 abnormal long bone metaphysis morphology 0.128598916729276 0.345997014346701 0.829336861253514 0.459459459459459 27.1 27 1 abnormal long bone morphology 0.0635570694402403 0.224093848664206 0.828537115003511 0.459016393442623 27.1 27 1 abnormal osteoclast morphology 0.0942871233461648 0.309418495149848 0.827304172868089 0.458333333333333 27.1 27 1 abnormal startle reflex 0.20196653628913 0.487179931788817 0.827304172868089 0.458333333333333 27.1 27 1 small lymph nodes 0.20196653628913 0.487179931788817 0.827304172868089 0.458333333333333 27.1 27 1 decreased fatty acid level 0.20196653628913 0.487179931788817 0.827304172868089 0.458333333333333 27.1 27 1 hypopigmentation 0.20196653628913 0.487179931788817 0.827304172868089 0.458333333333333 27.1 27 1 abnormal inner cell mass apoptosis 0.20196653628913 0.487179931788817 0.827304172868089 0.458333333333333 27.1 27 1 thick pulmonary interalveolar septum 0.143284091855312 0.367821649628574 0.825155330860639 0.457142857142857 27.1 27 1 impaired adaptive thermogenesis 0.143284091855312 0.367821649628574 0.825155330860639 0.457142857142857 27.1 27 1 increased sensitivity to induced morbidity/mortality 0.00321950956951005 0.0266506823765599 0.824034195900231 0.456521739130435 27.1 27 1 abnormal lymphocyte physiology 0.104476020038799 0.333184743392964 0.824034195900231 0.456521739130435 27.1 27 1 abnormal circulating amino acid level 0.0774411378338836 0.264123969750131 0.823345779696471 0.456140350877193 27.1 27 1 abnormal T cell differentiation 0.025457127817905 0.127799405543973 0.822091635325266 0.455445544554455 27.1 27 1 abnormal epidermis stratum basale morphology 0.159808771211674 0.403371914842955 0.820466948298931 0.454545454545455 27.1 27 1 deafness 0.0278947915376134 0.131791631433644 0.820466948298931 0.454545454545455 27.1 27 1 parakeratosis 0.227665853739009 0.533759482729297 0.820466948298931 0.454545454545455 27.1 27 1 abnormal mesenteric lymph node morphology 0.227665853739009 0.533759482729297 0.820466948298931 0.454545454545455 27.1 27 1 abnormal temporal bone morphology 0.227665853739009 0.533759482729297 0.820466948298931 0.454545454545455 27.1 27 1 failure of palatal shelf elevation 0.227665853739009 0.533759482729297 0.820466948298931 0.454545454545455 27.1 27 1 decreased atrioventricular cushion size 0.348788435141687 0.588082919926276 0.820466948298931 0.454545454545455 27.1 27 1 abnormal awl hair morphology 0.348788435141687 0.588082919926276 0.820466948298931 0.454545454545455 27.1 27 1 enlarged cranium 0.348788435141687 0.588082919926276 0.820466948298931 0.454545454545455 27.1 27 1 abnormal large intestine morphology 0.348788435141687 0.588082919926276 0.820466948298931 0.454545454545455 27.1 27 1 abnormal hypothalamus secretion 0.348788435141687 0.588082919926276 0.820466948298931 0.454545454545455 27.1 27 1 vasculitis 0.348788435141687 0.588082919926276 0.820466948298931 0.454545454545455 27.1 27 1 variable body spotting 0.348788435141687 0.588082919926276 0.820466948298931 0.454545454545455 27.1 27 1 pulmonary hypertension 0.348788435141687 0.588082919926276 0.820466948298931 0.454545454545455 27.1 27 1 pathological neovascularization 0.348788435141687 0.588082919926276 0.820466948298931 0.454545454545455 27.1 27 1 increased motor neuron number 0.348788435141687 0.588082919926276 0.820466948298931 0.454545454545455 27.1 27 1 abnormal platelet aggregation 0.348788435141687 0.588082919926276 0.820466948298931 0.454545454545455 27.1 27 1 abnormal palate development 0.348788435141687 0.588082919926276 0.820466948298931 0.454545454545455 27.1 27 1 enhanced behavioral response to addictive substance 0.348788435141687 0.588082919926276 0.820466948298931 0.454545454545455 27.1 27 1 abnormal aorta smooth muscle morphology 0.348788435141687 0.588082919926276 0.820466948298931 0.454545454545455 27.1 27 1 abnormal palatal shelf elevation 0.348788435141687 0.588082919926276 0.820466948298931 0.454545454545455 27.1 27 1 aberrant origin of the right subclavian artery 0.348788435141687 0.588082919926276 0.820466948298931 0.454545454545455 27.1 27 1 abnormal brain ependyma motile cilium morphology 0.348788435141687 0.588082919926276 0.820466948298931 0.454545454545455 27.1 27 1 chylous ascites 0.348788435141687 0.588082919926276 0.820466948298931 0.454545454545455 27.1 27 1 decreased T cell proliferation 0.00983093954429275 0.0637719076715565 0.817140730940963 0.452702702702703 27.1 27 1 abnormal podocyte morphology 0.178438392533207 0.445188633723746 0.815173613148615 0.451612903225806 27.1 27 1 corneal opacity 0.0639951095940874 0.225478519993332 0.81353342479218 0.450704225352113 27.1 27 1 decreased IgG level 0.0256650802742824 0.128713482222334 0.813075354170112 0.45045045045045 27.1 27 1 impaired ovarian folliculogenesis 0.142616028175726 0.366842261783015 0.812262278815942 0.45 27.1 27 1 waved hair 0.257302677775913 0.57922209137338 0.812262278815942 0.45 27.1 27 1 abnormal trachea morphology 0.257302677775913 0.57922209137338 0.812262278815942 0.45 27.1 27 1 abnormal thymocyte activation 0.257302677775913 0.57922209137338 0.812262278815942 0.45 27.1 27 1 abnormal incus morphology 0.257302677775913 0.57922209137338 0.812262278815942 0.45 27.1 27 1 abnormal induced retinal neovascularization 0.257302677775913 0.57922209137338 0.812262278815942 0.45 27.1 27 1 abnormal middle ear morphology 0.199485067026791 0.48340877177705 0.809150162805153 0.448275862068966 27.1 27 1 abnormal parietal bone morphology 0.199485067026791 0.48340877177705 0.809150162805153 0.448275862068966 27.1 27 1 decreased retinal photoreceptor cell number 0.199485067026791 0.48340877177705 0.809150162805153 0.448275862068966 27.1 27 1 abnormal outer ear morphology 0.199485067026791 0.48340877177705 0.809150162805153 0.448275862068966 27.1 27 1 enlarged epididymis 0.199485067026791 0.48340877177705 0.809150162805153 0.448275862068966 27.1 27 1 circling 0.0529010096935118 0.208049425474483 0.806953375032831 0.447058823529412 27.1 27 1 abnormal T-helper 1 physiology 0.127606923403766 0.3453995886473 0.806501553434269 0.446808510638298 27.1 27 1 abnormal skin appearance 0.223317955066047 0.527293225654287 0.802234349447844 0.444444444444444 27.1 27 1 abnormal bone trabecula morphology 0.223317955066047 0.527293225654287 0.802234349447844 0.444444444444444 27.1 27 1 renal hypoplasia 0.176057723826803 0.439923242610922 0.802234349447844 0.444444444444444 27.1 27 1 narrow eye opening 0.176057723826803 0.439923242610922 0.802234349447844 0.444444444444444 27.1 27 1 abnormal radius morphology 0.291683567827176 0.588082919926276 0.802234349447844 0.444444444444444 27.1 27 1 abnormal retinal rod cell morphology 0.291683567827176 0.588082919926276 0.802234349447844 0.444444444444444 27.1 27 1 thick dermal layer 0.291683567827176 0.588082919926276 0.802234349447844 0.444444444444444 27.1 27 1 decreased IgM level 0.0478485584308294 0.19259431892668 0.800166735145143 0.443298969072165 27.1 27 1 abnormal response to infection 0.0695731519367125 0.240699882395789 0.799695633152123 0.443037974683544 27.1 27 1 thick epidermis 0.0843754518700348 0.282768019554924 0.799369226771244 0.442857142857143 27.1 27 1 impaired macrophage phagocytosis 0.156212103295868 0.399976950024161 0.79757019625338 0.441860465116279 27.1 27 1 lung inflammation 0.025249870768345 0.126886976840926 0.79633556746661 0.441176470588235 27.1 27 1 increased width of hypertrophic chondrocyte zone 0.195827022981676 0.478741739230387 0.79633556746661 0.441176470588235 27.1 27 1 decreased osteoblast cell number 0.195827022981676 0.478741739230387 0.79633556746661 0.441176470588235 27.1 27 1 increased susceptibility to viral infection induced morbidity/mortality 0.195827022981676 0.478741739230387 0.79633556746661 0.441176470588235 27.1 27 1 abnormal circulating protein level 0.139175981111326 0.361378134670588 0.794212005953365 0.44 27.1 27 1 abnormal inner ear vestibule morphology 0.250376523620007 0.565164793561496 0.794212005953365 0.44 27.1 27 1 increased pre-B cell number 0.250376523620007 0.565164793561496 0.794212005953365 0.44 27.1 27 1 increased tumor growth/size 0.172938045687868 0.433765706214166 0.79245100372287 0.439024390243902 27.1 27 1 short ulna 0.172938045687868 0.433765706214166 0.79245100372287 0.439024390243902 27.1 27 1 polydipsia 0.217989578064989 0.515690989478516 0.789699437737721 0.4375 27.1 27 1 abnormal lymphatic vessel morphology 0.217989578064989 0.515690989478516 0.789699437737721 0.4375 27.1 27 1 decreased mast cell number 0.331854579597552 0.588082919926276 0.789699437737721 0.4375 27.1 27 1 abnormal hair follicle orientation 0.331854579597552 0.588082919926276 0.789699437737721 0.4375 27.1 27 1 abnormal mouth morphology 0.331854579597552 0.588082919926276 0.789699437737721 0.4375 27.1 27 1 disorganized retinal layers 0.331854579597552 0.588082919926276 0.789699437737721 0.4375 27.1 27 1 poor circulation 0.331854579597552 0.588082919926276 0.789699437737721 0.4375 27.1 27 1 abnormal extraembryonic endoderm formation 0.331854579597552 0.588082919926276 0.789699437737721 0.4375 27.1 27 1 white spotting 0.331854579597552 0.588082919926276 0.789699437737721 0.4375 27.1 27 1 abnormal amnion morphology 0.331854579597552 0.588082919926276 0.789699437737721 0.4375 27.1 27 1 decreased circulating growth hormone level 0.331854579597552 0.588082919926276 0.789699437737721 0.4375 27.1 27 1 increased circulating estradiol level 0.331854579597552 0.588082919926276 0.789699437737721 0.4375 27.1 27 1 abnormal intestinal lipid absorption 0.331854579597552 0.588082919926276 0.789699437737721 0.4375 27.1 27 1 abnormal Langerhans cell physiology 0.331854579597552 0.588082919926276 0.789699437737721 0.4375 27.1 27 1 decreased circulating triiodothyronine level 0.331854579597552 0.588082919926276 0.789699437737721 0.4375 27.1 27 1 decreased skeletal muscle weight 0.331854579597552 0.588082919926276 0.789699437737721 0.4375 27.1 27 1 dilated respiratory conducting tubes 0.331854579597552 0.588082919926276 0.789699437737721 0.4375 27.1 27 1 decreased midbrain size 0.331854579597552 0.588082919926276 0.789699437737721 0.4375 27.1 27 1 abnormal response to injury 0.191533223157453 0.469166807094204 0.786806765804616 0.435897435897436 27.1 27 1 abnormal circulating hormone level 0.191533223157453 0.469166807094204 0.786806765804616 0.435897435897436 27.1 27 1 delayed wound healing 0.169378185369126 0.426661504917167 0.784794472285934 0.434782608695652 27.1 27 1 abnormal carpal bone morphology 0.281187613702909 0.588082919926276 0.784794472285934 0.434782608695652 27.1 27 1 blistering 0.281187613702909 0.588082919926276 0.784794472285934 0.434782608695652 27.1 27 1 failure of embryo implantation 0.281187613702909 0.588082919926276 0.784794472285934 0.434782608695652 27.1 27 1 conjunctivitis 0.281187613702909 0.588082919926276 0.784794472285934 0.434782608695652 27.1 27 1 abnormal cardiovascular development 0.281187613702909 0.588082919926276 0.784794472285934 0.434782608695652 27.1 27 1 decreased epididymis weight 0.281187613702909 0.588082919926276 0.784794472285934 0.434782608695652 27.1 27 1 abnormal ulna morphology 0.281187613702909 0.588082919926276 0.784794472285934 0.434782608695652 27.1 27 1 increased susceptibility to fungal infection 0.281187613702909 0.588082919926276 0.784794472285934 0.434782608695652 27.1 27 1 increased lymphocyte cell number 0.109703037283198 0.344555928388158 0.784794472285934 0.434782608695652 27.1 27 1 abnormal lactation 0.24286680708476 0.554799238544477 0.782178490711648 0.433333333333333 27.1 27 1 increased granulocyte number 0.107758113145566 0.342772770395901 0.780552340003307 0.432432432432432 27.1 27 1 short femur 0.0872374698040132 0.290694181028108 0.779443600883984 0.431818181818182 27.1 27 1 hypertension 0.186904009558534 0.458504658557054 0.779443600883984 0.431818181818182 27.1 27 1 polyuria 0.115342132063447 0.344555928388158 0.773583122681849 0.428571428571429 27.1 27 1 impaired behavioral response to xenobiotic 0.235234221326449 0.548659283215698 0.773583122681849 0.428571428571429 27.1 27 1 abnormal stria vascularis morphology 0.270828614131639 0.588082919926276 0.773583122681849 0.428571428571429 27.1 27 1 absent otoliths 0.379204514895741 0.609348340312116 0.773583122681849 0.428571428571429 27.1 27 1 abnormal sagittal suture morphology 0.379204514895741 0.609348340312116 0.773583122681849 0.428571428571429 27.1 27 1 abnormal positive T cell selection 0.379204514895741 0.609348340312116 0.773583122681849 0.428571428571429 27.1 27 1 decreased CNS synapse formation 0.379204514895741 0.609348340312116 0.773583122681849 0.428571428571429 27.1 27 1 premature hair loss 0.379204514895741 0.609348340312116 0.773583122681849 0.428571428571429 27.1 27 1 decreased cornea thickness 0.379204514895741 0.609348340312116 0.773583122681849 0.428571428571429 27.1 27 1 increased lung compliance 0.379204514895741 0.609348340312116 0.773583122681849 0.428571428571429 27.1 27 1 abnormal respiratory motile cilium physiology 0.379204514895741 0.609348340312116 0.773583122681849 0.428571428571429 27.1 27 1 abnormal cartilage morphology 0.206276447530703 0.496720874378144 0.773583122681849 0.428571428571429 27.1 27 1 abnormal stapes morphology 0.316387526668823 0.588082919926276 0.773583122681849 0.428571428571429 27.1 27 1 abnormal clavicle morphology 0.316387526668823 0.588082919926276 0.773583122681849 0.428571428571429 27.1 27 1 abnormal male meiosis 0.157593761157314 0.403119241304485 0.76935589250326 0.426229508196721 27.1 27 1 decreased tumor growth/size 0.177275809896778 0.442744555339594 0.76880791822085 0.425925925925926 27.1 27 1 abnormal tooth development 0.260859646272695 0.581333538218853 0.765769151745669 0.424242424242424 27.1 27 1 dilated heart atrium 0.260859646272695 0.581333538218853 0.765769151745669 0.424242424242424 27.1 27 1 diarrhea 0.260859646272695 0.581333538218853 0.765769151745669 0.424242424242424 27.1 27 1 abnormal skin condition 0.194432671434435 0.476034714757045 0.763665390339774 0.423076923076923 27.1 27 1 altered response to myocardial infarction 0.220332431939024 0.520738170497218 0.762122631975451 0.422222222222222 27.1 27 1 decreased osteoclast cell number 0.220332431939024 0.520738170497218 0.762122631975451 0.422222222222222 27.1 27 1 abnormal cytokine secretion 0.0539765441144942 0.21083722131187 0.761862166277579 0.422077922077922 27.1 27 1 abnormal blood homeostasis 0.0906022459129389 0.301502457135031 0.760011488950589 0.421052631578947 27.1 27 1 increased macrophage cell number 0.188663883779652 0.462593800790422 0.760011488950589 0.421052631578947 27.1 27 1 abnormal nail morphology 0.356750603484925 0.588082919926276 0.760011488950589 0.421052631578947 27.1 27 1 decreased susceptibility to weight gain 0.356750603484925 0.588082919926276 0.760011488950589 0.421052631578947 27.1 27 1 abnormal epidermal layer morphology 0.163005901197161 0.410817810767922 0.75863465654307 0.420289855072464 27.1 27 1 autoimmune response 0.289398439816437 0.588082919926276 0.756946926495143 0.419354838709677 27.1 27 1 decreased double-negative T cell number 0.289398439816437 0.588082919926276 0.756946926495143 0.419354838709677 27.1 27 1 decreased compact bone thickness 0.17757949741919 0.44328048151554 0.754339761421107 0.417910447761194 27.1 27 1 increased susceptibility to bacterial infection induced morbidity/mortality 0.172285783523945 0.433765706214166 0.752094702607354 0.416666666666667 27.1 27 1 abnormal kidney physiology 0.233746673363634 0.545445450273958 0.752094702607353 0.416666666666667 27.1 27 1 increased circulating total protein level 0.337774097569893 0.588082919926276 0.752094702607353 0.416666666666667 27.1 27 1 abnormal rectum morphology 0.435629135206107 0.678073069404116 0.752094702607353 0.416666666666667 27.1 27 1 amyloidosis 0.435629135206107 0.678073069404116 0.752094702607353 0.416666666666667 27.1 27 1 abnormal pilomotor reflex 0.435629135206107 0.678073069404116 0.752094702607353 0.416666666666667 27.1 27 1 myocarditis 0.435629135206107 0.678073069404116 0.752094702607353 0.416666666666667 27.1 27 1 abnormal embryonic growth/weight/body size 0.435629135206107 0.678073069404116 0.752094702607353 0.416666666666667 27.1 27 1 abnormal tracheal ciliated epithelium morphology 0.435629135206107 0.678073069404116 0.752094702607353 0.416666666666667 27.1 27 1 increased circulating parathyroid hormone level 0.435629135206107 0.678073069404116 0.752094702607353 0.416666666666667 27.1 27 1 small thyroid gland 0.435629135206107 0.678073069404116 0.752094702607353 0.416666666666667 27.1 27 1 abnormal aorta elastic fiber morphology 0.435629135206107 0.678073069404116 0.752094702607353 0.416666666666667 27.1 27 1 absent tail 0.435629135206107 0.678073069404116 0.752094702607353 0.416666666666667 27.1 27 1 decreased circulating ketone body level 0.435629135206107 0.678073069404116 0.752094702607353 0.416666666666667 27.1 27 1 absent cochlear hair cells 0.435629135206107 0.678073069404116 0.752094702607353 0.416666666666667 27.1 27 1 decreased cochlear nerve compound action potential 0.435629135206107 0.678073069404116 0.752094702607353 0.416666666666667 27.1 27 1 decreased keratinocyte proliferation 0.435629135206107 0.678073069404116 0.752094702607353 0.416666666666667 27.1 27 1 abnormal behavioral response to addictive substance 0.435629135206107 0.678073069404116 0.752094702607353 0.416666666666667 27.1 27 1 increased type II pneumocyte number 0.435629135206107 0.678073069404116 0.752094702607353 0.416666666666667 27.1 27 1 decreased compensatory feeding amount 0.435629135206107 0.678073069404116 0.752094702607353 0.416666666666667 27.1 27 1 abnormal colon goblet cell morphology 0.435629135206107 0.678073069404116 0.752094702607353 0.416666666666667 27.1 27 1 abnormal immune system morphology 0.256189123969692 0.578023080158376 0.745554748671637 0.41304347826087 27.1 27 1 abnormal trabecular bone morphology 0.122574083740349 0.344555928388158 0.743246529635502 0.411764705882353 27.1 27 1 abnormal bone remodeling 0.306382482576408 0.588082919926276 0.743246529635502 0.411764705882353 27.1 27 1 decreased regulatory T cell number 0.306382482576408 0.588082919926276 0.743246529635502 0.411764705882353 27.1 27 1 hydroureter 0.403225775806033 0.644617041977833 0.743246529635502 0.411764705882353 27.1 27 1 abnormal circulating chemokine level 0.403225775806033 0.644617041977833 0.743246529635502 0.411764705882353 27.1 27 1 increased vascular permeability 0.292969919354091 0.588082919926276 0.740524014874933 0.41025641025641 27.1 27 1 increased osteoclast cell number 0.228993754505537 0.536619843930781 0.739765281253135 0.409836065573771 27.1 27 1 abnormal basisphenoid bone morphology 0.37781022331254 0.608680654462398 0.738420253469038 0.409090909090909 27.1 27 1 abnormal long bone epiphysis morphology 0.37781022331254 0.608680654462398 0.738420253469038 0.409090909090909 27.1 27 1 intestinal ulcer 0.37781022331254 0.608680654462398 0.738420253469038 0.409090909090909 27.1 27 1 intestinal inflammation 0.37781022331254 0.608680654462398 0.738420253469038 0.409090909090909 27.1 27 1 abnormal epidermis stratum corneum morphology 0.269354249815853 0.588082919926276 0.736745831125571 0.408163265306122 27.1 27 1 wrinkled skin 0.356601809270002 0.588082919926276 0.735381486993857 0.407407407407407 27.1 27 1 abnormal colon morphology 0.248991028098563 0.562803436978806 0.73424838763023 0.406779661016949 27.1 27 1 abnormal cytotoxic T cell physiology 0.307404350170643 0.588082919926276 0.730606282532858 0.404761904761905 27.1 27 1 abnormal tibia morphology 0.294100409624789 0.588082919926276 0.729691881678624 0.404255319148936 27.1 27 1 abnormal femur morphology 0.250201806836335 0.565164793561496 0.727399055656067 0.402985074626866 27.1 27 1 dehydration 0.260305403066673 0.581333538218853 0.722010914503059 0.4 27.1 27 1 abnormal incisor morphology 0.281830738731133 0.588082919926276 0.722010914503059 0.4 27.1 27 1 arrested T cell differentiation 0.373403403658793 0.602361197536477 0.722010914503059 0.4 27.1 27 1 salivary gland inflammation 0.373403403658793 0.602361197536477 0.722010914503059 0.4 27.1 27 1 abnormal estrous cycle 0.373403403658793 0.602361197536477 0.722010914503059 0.4 27.1 27 1 abnormal pain threshold 0.373403403658793 0.602361197536477 0.722010914503059 0.4 27.1 27 1 abnormal feces composition 0.396039146869817 0.633739065833818 0.722010914503059 0.4 27.1 27 1 impaired conditioned place preference behavior 0.396039146869817 0.633739065833818 0.722010914503059 0.4 27.1 27 1 decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 0.396039146869817 0.633739065833818 0.722010914503059 0.4 27.1 27 1 increased airway responsiveness 0.456981488569114 0.689352002920358 0.722010914503059 0.4 27.1 27 1 abnormal cricoid cartilage morphology 0.456981488569114 0.689352002920358 0.722010914503059 0.4 27.1 27 1 altered righting response 0.456981488569114 0.689352002920358 0.722010914503059 0.4 27.1 27 1 abnormal zygomatic bone morphology 0.456981488569114 0.689352002920358 0.722010914503059 0.4 27.1 27 1 abnormal cartilage development 0.32092773413404 0.588082919926276 0.722010914503059 0.4 27.1 27 1 brain inflammation 0.423049220624266 0.669211406233935 0.722010914503059 0.4 27.1 27 1 abnormal hair texture 0.423049220624266 0.669211406233935 0.722010914503059 0.4 27.1 27 1 abnormal hyoid bone morphology 0.423049220624266 0.669211406233935 0.722010914503059 0.4 27.1 27 1 abnormal heart electrocardiography waveform feature 0.423049220624266 0.669211406233935 0.722010914503059 0.4 27.1 27 1 abnormal lymph node morphology 0.333642512692443 0.588082919926276 0.714489967476986 0.395833333333333 27.1 27 1 abnormal aorta morphology 0.388565502176109 0.623182905649949 0.711071355192407 0.393939393939394 27.1 27 1 abnormal T cell subpopulation ratio 0.388565502176109 0.623182905649949 0.711071355192407 0.393939393939394 27.1 27 1 abnormal middle ear ossicle morphology 0.388565502176109 0.623182905649949 0.711071355192407 0.393939393939394 27.1 27 1 decreased sensitivity to xenobiotic induced morbidity/mortality 0.388565502176109 0.623182905649949 0.711071355192407 0.393939393939394 27.1 27 1 increased circulating luteinizing hormone level 0.41210211200659 0.653348632005348 0.709117862458362 0.392857142857143 27.1 27 1 decreased circulating progesterone level 0.41210211200659 0.653348632005348 0.709117862458362 0.392857142857143 27.1 27 1 abnormal retinal cone cell morphology 0.439924758061589 0.678073069404116 0.706315025057341 0.391304347826087 27.1 27 1 bidirectional circling 0.439924758061589 0.678073069404116 0.706315025057341 0.391304347826087 27.1 27 1 abnormal cochlear ganglion morphology 0.439924758061589 0.678073069404116 0.706315025057341 0.391304347826087 27.1 27 1 abnormal crista ampullaris morphology 0.439924758061589 0.678073069404116 0.706315025057341 0.391304347826087 27.1 27 1 abnormal regulatory T cell physiology 0.439924758061589 0.678073069404116 0.706315025057341 0.391304347826087 27.1 27 1 abnormal humoral immune response 0.26383912110649 0.583118448469474 0.704820178443463 0.39047619047619 27.1 27 1 increased B cell proliferation 0.341122318014227 0.588082919926276 0.703654704812304 0.389830508474576 27.1 27 1 impaired wound healing 0.402376525871953 0.643673059875551 0.701955055766863 0.388888888888889 27.1 27 1 abnormal stomach glandular epithelium morphology 0.474207180883488 0.713605784904826 0.701955055766863 0.388888888888889 27.1 27 1 increased circulating renin level 0.474207180883488 0.713605784904826 0.701955055766863 0.388888888888889 27.1 27 1 decreased activity of thyroid 0.474207180883488 0.713605784904826 0.701955055766863 0.388888888888889 27.1 27 1 decreased heart rate variability 0.474207180883488 0.713605784904826 0.701955055766863 0.388888888888889 27.1 27 1 abnormal sperm axoneme morphology 0.474207180883488 0.713605784904826 0.701955055766863 0.388888888888889 27.1 27 1 renal interstitial fibrosis 0.393570919486626 0.630600748613837 0.697396906054091 0.386363636363636 27.1 27 1 cochlear hair cell degeneration 0.393570919486626 0.630600748613837 0.697396906054091 0.386363636363636 27.1 27 1 increased susceptibility to injury 0.385484563458163 0.619039930020775 0.694241263945249 0.384615384615385 27.1 27 1 abnormal lens fiber morphology 0.415056738569814 0.657404417187146 0.694241263945249 0.384615384615385 27.1 27 1 abnormal leukocyte adhesion 0.415056738569814 0.657404417187146 0.694241263945249 0.384615384615385 27.1 27 1 increased autoantibody level 0.415056738569814 0.657404417187146 0.694241263945249 0.384615384615385 27.1 27 1 pulmonary edema 0.454625501301265 0.686630804181479 0.694241263945249 0.384615384615385 27.1 27 1 decreased Peyer's patch number 0.454625501301265 0.686630804181479 0.694241263945249 0.384615384615385 27.1 27 1 absent trabeculae carneae 0.519454533184957 0.760531578162202 0.694241263945249 0.384615384615385 27.1 27 1 abnormal otolith morphology 0.519454533184957 0.760531578162202 0.694241263945249 0.384615384615385 27.1 27 1 abnormal dopaminergic neuron morphology 0.519454533184957 0.760531578162202 0.694241263945249 0.384615384615385 27.1 27 1 decreased alcohol consumption 0.519454533184957 0.760531578162202 0.694241263945249 0.384615384615385 27.1 27 1 abnormal vestibulocochlear ganglion morphology 0.519454533184957 0.760531578162202 0.694241263945249 0.384615384615385 27.1 27 1 small otic vesicle 0.519454533184957 0.760531578162202 0.694241263945249 0.384615384615385 27.1 27 1 vestibular hair cell degeneration 0.519454533184957 0.760531578162202 0.694241263945249 0.384615384615385 27.1 27 1 decreased follicle stimulating hormone level 0.519454533184957 0.760531578162202 0.694241263945249 0.384615384615385 27.1 27 1 increased renin activity 0.519454533184957 0.760531578162202 0.694241263945249 0.384615384615385 27.1 27 1 decreased susceptibility to injury 0.37095579142604 0.599189955306672 0.690157491804395 0.382352941176471 27.1 27 1 short maxilla 0.439440704785448 0.678073069404116 0.690157491804395 0.382352941176471 27.1 27 1 abnormal T-helper 2 physiology 0.395998046065537 0.633739065833818 0.689192236571102 0.381818181818182 27.1 27 1 hypoalgesia 0.488687186135308 0.723146564849244 0.687629442383866 0.380952380952381 27.1 27 1 increased acute inflammation 0.488687186135308 0.723146564849244 0.687629442383866 0.380952380952381 27.1 27 1 abnormal bile salt homeostasis 0.488687186135308 0.723146564849244 0.687629442383866 0.380952380952381 27.1 27 1 increased keratinocyte proliferation 0.488687186135308 0.723146564849244 0.687629442383866 0.380952380952381 27.1 27 1 abnormal tumor vascularization 0.488687186135308 0.723146564849244 0.687629442383866 0.380952380952381 27.1 27 1 abnormal circulating glucose level 0.467660268492785 0.705246994771629 0.684665522373591 0.379310344827586 27.1 27 1 abnormal T cell activation 0.388853183865276 0.623443309613196 0.682983297502894 0.378378378378378 27.1 27 1 abnormal hair follicle development 0.451291289480301 0.682009163172691 0.682983297502894 0.378378378378378 27.1 27 1 abnormal response/metabolism to endogenous compounds 0.381236421397606 0.612415626881851 0.682388364316916 0.378048780487805 27.1 27 1 abnormal crypts of Lieberkuhn morphology 0.479380391654308 0.71524398236964 0.676885232346618 0.375 27.1 27 1 delayed hair appearance 0.532057633952051 0.772378800902237 0.676885232346618 0.375 27.1 27 1 abnormal pituitary gland morphology 0.532057633952051 0.772378800902237 0.676885232346618 0.375 27.1 27 1 mixed cellular infiltration to dermis 0.532057633952051 0.772378800902237 0.676885232346618 0.375 27.1 27 1 abnormal intestinal absorption 0.532057633952051 0.772378800902237 0.676885232346618 0.375 27.1 27 1 decreased cochlear coiling 0.532057633952051 0.772378800902237 0.676885232346618 0.375 27.1 27 1 abnormal molar crown morphology 0.532057633952051 0.772378800902237 0.676885232346618 0.375 27.1 27 1 abnormal epididymis epithelium morphology 0.532057633952051 0.772378800902237 0.676885232346618 0.375 27.1 27 1 increased thymus weight 0.532057633952051 0.772378800902237 0.676885232346618 0.375 27.1 27 1 abnormal intestinal epithelium morphology 0.44786011971171 0.678073069404116 0.676885232346618 0.375 27.1 27 1 abnormal malleus morphology 0.501215154356606 0.740228279329092 0.676885232346618 0.375 27.1 27 1 abnormal foregut morphology 0.501215154356606 0.740228279329092 0.676885232346618 0.375 27.1 27 1 decreased metastatic potential 0.501215154356606 0.740228279329092 0.676885232346618 0.375 27.1 27 1 abnormal intestinal mucosa morphology 0.472300783393344 0.712029211327844 0.671638060002846 0.372093023255814 27.1 27 1 decreased susceptibility to induced arthritis 0.474951646096495 0.714509960486865 0.665010052831765 0.368421052631579 27.1 27 1 decreased tumor incidence 0.542723517699317 0.772378800902237 0.665010052831765 0.368421052631579 27.1 27 1 decreased liver glycogen level 0.542723517699317 0.772378800902237 0.665010052831765 0.368421052631579 27.1 27 1 gastrointestinal hemorrhage 0.522230032344043 0.764145414974005 0.661843338294471 0.366666666666667 27.1 27 1 increased neutrophil cell number 0.441070221951932 0.678073069404116 0.659768594287278 0.36551724137931 27.1 27 1 abnormal urine homeostasis 0.472515810471352 0.712137581670699 0.658082864781434 0.364583333333333 27.1 27 1 absent vibrissae 0.531274614213279 0.772378800902237 0.656373558639145 0.363636363636364 27.1 27 1 abnormal gametogenesis 0.517289277054326 0.759372721553636 0.656373558639145 0.363636363636364 27.1 27 1 decreased macrophage cell number 0.517289277054326 0.759372721553636 0.656373558639145 0.363636363636364 27.1 27 1 abnormal tracheal cartilage morphology 0.552045450605462 0.772378800902237 0.656373558639145 0.363636363636364 27.1 27 1 rough coat 0.552045450605462 0.772378800902237 0.656373558639145 0.363636363636364 27.1 27 1 impaired humoral immune response 0.552045450605462 0.772378800902237 0.656373558639145 0.363636363636364 27.1 27 1 abnormal inflammatory response 0.511800568021123 0.751759027429904 0.651815408926373 0.361111111111111 27.1 27 1 abnormal systemic arterial blood pressure 0.53958565666905 0.772378800902237 0.651815408926373 0.361111111111111 27.1 27 1 head tilt 0.53958565666905 0.772378800902237 0.651815408926373 0.361111111111111 27.1 27 1 abnormal NK cell physiology 0.521172701590775 0.762822650901473 0.650993447502758 0.360655737704918 27.1 27 1 abnormal digestive system physiology 0.532592946388285 0.772378800902237 0.649809823052753 0.36 27.1 27 1 abnormal vasoconstriction 0.597371210012299 0.781673269282269 0.644652602234874 0.357142857142857 27.1 27 1 abnormal zigzag hair morphology 0.597371210012299 0.781673269282269 0.644652602234874 0.357142857142857 27.1 27 1 abnormal olfactory system physiology 0.597371210012299 0.781673269282269 0.644652602234874 0.357142857142857 27.1 27 1 abnormal spleen periarteriolar lymphoid sheath morphology 0.597371210012299 0.781673269282269 0.644652602234874 0.357142857142857 27.1 27 1 abnormal kidney medulla morphology 0.597371210012299 0.781673269282269 0.644652602234874 0.357142857142857 27.1 27 1 abnormal vascular endothelial cell migration 0.597371210012299 0.781673269282269 0.644652602234874 0.357142857142857 27.1 27 1 abnormal uterus development 0.597371210012299 0.781673269282269 0.644652602234874 0.357142857142857 27.1 27 1 decreased susceptibility to bacterial infection induced morbidity/mortality 0.574904006470428 0.772378800902237 0.640493553188198 0.354838709677419 27.1 27 1 abnormal intestine physiology 0.574904006470428 0.772378800902237 0.640493553188198 0.354838709677419 27.1 27 1 decreased pancreatic beta cell number 0.581365837537551 0.772378800902237 0.637068453973288 0.352941176470588 27.1 27 1 abnormal skin physiology 0.581365837537551 0.772378800902237 0.637068453973288 0.352941176470588 27.1 27 1 enlarged sebaceous gland 0.602329556577151 0.78774698842569 0.637068453973288 0.352941176470588 27.1 27 1 abnormal tendon morphology 0.602329556577151 0.78774698842569 0.637068453973288 0.352941176470588 27.1 27 1 increased insulin secretion 0.587411772229623 0.772378800902237 0.634198776252687 0.351351351351351 27.1 27 1 impaired natural killer cell mediated cytotoxicity 0.584783221589578 0.772378800902237 0.633342907458824 0.350877192982456 27.1 27 1 increased urine glucose level 0.607163523816652 0.793026655549448 0.631759550190177 0.35 27.1 27 1 abnormal Peyer's patch T cell area morphology 0.607163523816652 0.793026655549448 0.631759550190177 0.35 27.1 27 1 abnormal physiological neovascularization 0.607163523816652 0.793026655549448 0.631759550190177 0.35 27.1 27 1 nuclear cataracts 0.607163523816652 0.793026655549448 0.631759550190177 0.35 27.1 27 1 abnormal inner ear morphology 0.603612079998948 0.789216845727927 0.627835577828747 0.347826086956522 27.1 27 1 hypotension 0.611843153295527 0.798929051875393 0.627835577828747 0.347826086956522 27.1 27 1 abnormal immune system physiology 0.622578070872153 0.811880970534459 0.62593688152483 0.346774193548387 27.1 27 1 abnormal leukocyte migration 0.613174000691555 0.800456744539619 0.624817137550724 0.346153846153846 27.1 27 1 abnormal leukocyte cell number 0.616362565356157 0.803986303787855 0.624817137550724 0.346153846153846 27.1 27 1 abnormal kidney cortex morphology 0.616362565356157 0.803986303787855 0.624817137550724 0.346153846153846 27.1 27 1 heart inflammation 0.616362565356157 0.803986303787855 0.624817137550724 0.346153846153846 27.1 27 1 decreased susceptibility to parasitic infection 0.624940185659824 0.814747752530825 0.620478129651067 0.34375 27.1 27 1 increased systemic arterial blood pressure 0.644095856925239 0.839501411632975 0.614477374045157 0.340425531914894 27.1 27 1 vagina atresia 0.667566070733892 0.867818448367157 0.601675762085883 0.333333333333333 27.1 27 1 curly vibrissae 0.667157152764988 0.867818448367157 0.601675762085883 0.333333333333333 27.1 27 1 abnormal apical ectodermal ridge morphology 0.667566070733892 0.867818448367157 0.601675762085883 0.333333333333333 27.1 27 1 abnormal iron level 0.666390744423982 0.867818448367157 0.601675762085883 0.333333333333333 27.1 27 1 joint inflammation 0.667566070733892 0.867818448367157 0.601675762085883 0.333333333333333 27.1 27 1 increased vasoconstriction 0.666401692657324 0.867818448367157 0.601675762085883 0.333333333333333 27.1 27 1 abnormal rostral migratory stream morphology 0.667566070733892 0.867818448367157 0.601675762085883 0.333333333333333 27.1 27 1 lactation failure 0.667566070733892 0.867818448367157 0.601675762085883 0.333333333333333 27.1 27 1 abnormal macrophage chemotaxis 0.666390744423982 0.867818448367157 0.601675762085883 0.333333333333333 27.1 27 1 decreased trabecular bone mass 0.667566070733892 0.867818448367157 0.601675762085883 0.333333333333333 27.1 27 1 abnormal epidermis stratum granulosum morphology 0.673729954311548 0.874004308396337 0.601675762085883 0.333333333333333 27.1 27 1 decreased inflammatory response 0.708837845613659 0.901309451676906 0.601675762085883 0.333333333333333 27.1 27 1 decreased urine osmolality 0.718167890288212 0.901309451676906 0.589396664900457 0.326530612244898 27.1 27 1 decreased cytotoxic T cell cytolysis 0.715011165830967 0.901309451676906 0.58397941614218 0.323529411764706 27.1 27 1 abnormal body temperature homeostasis 0.715244640471273 0.901309451676906 0.582266866534725 0.32258064516129 27.1 27 1 abnormal T cell proliferation 0.715244640471273 0.901309451676906 0.582266866534725 0.32258064516129 27.1 27 1 decreased acute inflammation 0.717406797093018 0.901309451676906 0.577608731602448 0.32 27.1 27 1 abnormal stomach mucosa morphology 0.717406797093018 0.901309451676906 0.577608731602448 0.32 27.1 27 1 decreased grooming behavior 0.723467925989212 0.901309451676906 0.570008616712942 0.315789473684211 27.1 27 1 bowed tibia 0.729160814725638 0.901309451676906 0.564071026955515 0.3125 27.1 27 1 bowed radius 0.729160814725638 0.901309451676906 0.564071026955515 0.3125 27.1 27 1 abnormal wound healing 0.729160814725638 0.901309451676906 0.564071026955515 0.3125 27.1 27 1 sepsis 0.729160814725638 0.901309451676906 0.564071026955515 0.3125 27.1 27 1 abnormal urinary bladder physiology 0.729160814725638 0.901309451676906 0.564071026955515 0.3125 27.1 27 1 stomach inflammation 0.758851811511806 0.929187241513964 0.560180881942029 0.310344827586207 27.1 27 1 abnormal vibrissa morphology 0.785504563638411 0.955006159359993 0.558698921936891 0.30952380952381 27.1 27 1 abnormal tectorial membrane morphology 0.762315344531622 0.933198533229533 0.5553930111562 0.307692307692308 27.1 27 1 abnormal fibula morphology 0.773312669777452 0.945537625383322 0.541508185877295 0.3 27.1 27 1 decreased vasoconstriction 0.782007172287508 0.950986478154571 0.530890378311073 0.294117647058824 27.1 27 1 nephrocalcinosis 0.782007172287508 0.950986478154571 0.530890378311073 0.294117647058824 27.1 27 1 abnormal thrombosis 0.859929875014757 1 0.530890378311073 0.294117647058824 27.1 27 1 abnormal cellular extravasation 0.80809063027969 0.980788213135267 0.526466291825147 0.291666666666667 27.1 27 1 increased susceptibility to parasitic infection 0.928556956323524 1 0.521452327141098 0.288888888888889 27.1 27 1 decreased IgA level 0.880282742160569 1 0.520680947958937 0.288461538461538 27.1 27 1 abnormal thyroid cartilage morphology 0.826475029158094 0.98518717399221 0.501396468404902 0.277777777777778 27.1 27 1 acidosis 0.826475029158094 0.98518717399221 0.501396468404902 0.277777777777778 27.1 27 1 increased double-positive T cell number 0.865676642347314 1 0.497938561726248 0.275862068965517 27.1 27 1 increased activated T cell number 0.852192981254494 1 0.492280168979359 0.272727272727273 27.1 27 1 decreased susceptibility to viral infection induced morbidity/mortality 0.852192981254494 1 0.492280168979359 0.272727272727273 27.1 27 1 abnormal ear morphology 0.863263280289838 1 0.475007180594118 0.263157894736842 27.1 27 1 abnormal spleen germinal center morphology 0.91884845100333 1 0.451256821564412 0.25 27.1 27 1 decreased skin tensile strength 0.893246817127301 1 0.451256821564412 0.25 27.1 27 1 kidney atrophy 0.893246817127301 1 0.451256821564412 0.25 27.1 27 1 increased susceptibility to induced arthritis 0.935766753757517 1 0.435696241510467 0.241379310344828 27.1 27 1 abnormal hair shaft morphology 0.980006200203954 1 0.413652086434044 0.229166666666667 27.1 27 1 axonal dystrophy 1.99985814933544e-05 0.000245661587480095 1.29806259314456 1 27.3 27 3 abnormal kidney blood vessel morphology 8.69803539988454e-06 0.00011964315446473 1.29806259314456 1 27.3 27 3 sternebra fusion 8.69803539988454e-06 0.00011964315446473 1.29806259314456 1 27.3 27 3 abnormal AMPA-mediated synaptic currents 4.59791115662803e-05 0.000507197516723381 1.29806259314456 1 27.3 27 3 abnormal proximal-distal axis patterning 0.000105707383265356 0.00105601251354447 1.29806259314456 1 27.3 27 3 increased cranium width 0.000243015197672267 0.00218231156754428 1.29806259314456 1 27.3 27 3 ketoaciduria 0.000243015197672267 0.00218231156754428 1.29806259314456 1 27.3 27 3 abnormal inferior vena cava valve morphology 0.000243015197672267 0.00218231156754428 1.29806259314456 1 27.3 27 3 thin ventricle myocardium compact layer 0.000243015197672267 0.00218231156754428 1.29806259314456 1 27.3 27 3 decreased circulating lactate level 0.000243015197672267 0.00218231156754428 1.29806259314456 1 27.3 27 3 decreased fear-related response 0.000558656573514197 0.00440462195441066 1.29806259314456 1 27.3 27 3 decreased cochlear hair cell number 0.000558656573514197 0.00440462195441066 1.29806259314456 1 27.3 27 3 increased neuronal precursor cell number 0.000558656573514197 0.00440462195441066 1.29806259314456 1 27.3 27 3 abnormal CNS synapse formation 0.000558656573514197 0.00440462195441066 1.29806259314456 1 27.3 27 3 liver hyperplasia 0.000558656573514197 0.00440462195441066 1.29806259314456 1 27.3 27 3 abnormal hippocampus granule cell morphology 0.000558656573514197 0.00440462195441066 1.29806259314456 1 27.3 27 3 abnormal lung lobe morphology 0.000558656573514197 0.00440462195441066 1.29806259314456 1 27.3 27 3 early eyelid opening 0.00128422098056849 0.0091141217950474 1.29806259314456 1 27.3 27 3 abnormal somite size 0.00128422098056849 0.0091141217950474 1.29806259314456 1 27.3 27 3 abnormal cerebellum deep nucleus morphology 0.00128422098056849 0.0091141217950474 1.29806259314456 1 27.3 27 3 abnormal umbilical vein topology 0.00128422098056849 0.0091141217950474 1.29806259314456 1 27.3 27 3 growth retardation of molars 0.00295201104696316 0.0180073689007452 1.29806259314456 1 27.3 27 3 failure of atrioventricular cushion closure 0.00295201104696316 0.0180073689007452 1.29806259314456 1 27.3 27 3 broad head 0.00295201104696316 0.0180073689007452 1.29806259314456 1 27.3 27 3 skin photosensitivity 0.00295201104696316 0.0180073689007452 1.29806259314456 1 27.3 27 3 excessive tearing 0.00295201104696316 0.0180073689007452 1.29806259314456 1 27.3 27 3 abnormal brain ventricular system morphology 0.00295201104696316 0.0180073689007452 1.29806259314456 1 27.3 27 3 abnormal melanocyte morphology 0.00295201104696316 0.0180073689007452 1.29806259314456 1 27.3 27 3 decreased cardiomyocyte apoptosis 0.00295201104696316 0.0180073689007452 1.29806259314456 1 27.3 27 3 anuria 0.00295201104696316 0.0180073689007452 1.29806259314456 1 27.3 27 3 abnormal Purkinje cell innervation 0.00295201104696316 0.0180073689007452 1.29806259314456 1 27.3 27 3 abnormal optic tract morphology 0.00295201104696316 0.0180073689007452 1.29806259314456 1 27.3 27 3 absent deltoid tuberosity 0.00295201104696316 0.0180073689007452 1.29806259314456 1 27.3 27 3 heart hemorrhage 0.00295201104696316 0.0180073689007452 1.29806259314456 1 27.3 27 3 postaxial polydactyly 0.00295201104696316 0.0180073689007452 1.29806259314456 1 27.3 27 3 decreased brain cholesterol level 0.00295201104696316 0.0180073689007452 1.29806259314456 1 27.3 27 3 small lung lobe 0.00295201104696316 0.0180073689007452 1.29806259314456 1 27.3 27 3 ductus venosus stenosis 0.00295201104696316 0.0180073689007452 1.29806259314456 1 27.3 27 3 absent ectoplacental cone 0.00678546426476664 0.0340642630849788 1.29806259314456 1 27.3 27 3 reduced NMDA-mediated synaptic currents 0.00678546426476664 0.0340642630849788 1.29806259314456 1 27.3 27 3 abnormal gustatory system physiology 0.00678546426476664 0.0340642630849788 1.29806259314456 1 27.3 27 3 abnormal hippocampal fimbria morphology 0.00678546426476664 0.0340642630849788 1.29806259314456 1 27.3 27 3 esophageal atresia 0.00678546426476664 0.0340642630849788 1.29806259314456 1 27.3 27 3 increased glycerol level 0.00678546426476664 0.0340642630849788 1.29806259314456 1 27.3 27 3 enlarged pancreas 0.00678546426476664 0.0340642630849788 1.29806259314456 1 27.3 27 3 abnormal metopic suture morphology 0.00678546426476664 0.0340642630849788 1.29806259314456 1 27.3 27 3 abnormal right lung morphology 0.00678546426476664 0.0340642630849788 1.29806259314456 1 27.3 27 3 abnormal neural crest cell morphology 0.00678546426476664 0.0340642630849788 1.29806259314456 1 27.3 27 3 abnormal aorta tunica adventitia morphology 0.00678546426476664 0.0340642630849788 1.29806259314456 1 27.3 27 3 abnormal olfactory bulb layer morphology 0.00678546426476664 0.0340642630849788 1.29806259314456 1 27.3 27 3 ectopic hippocampus pyramidal cells 0.00678546426476664 0.0340642630849788 1.29806259314456 1 27.3 27 3 variable depigmentation 0.00678546426476664 0.0340642630849788 1.29806259314456 1 27.3 27 3 myocardium hypoplasia 0.00678546426476664 0.0340642630849788 1.29806259314456 1 27.3 27 3 common truncal valve 0.00678546426476664 0.0340642630849788 1.29806259314456 1 27.3 27 3 increased total retina thickness 0.00678546426476664 0.0340642630849788 1.29806259314456 1 27.3 27 3 delayed limb development 0.00678546426476664 0.0340642630849788 1.29806259314456 1 27.3 27 3 thymus cortex atrophy 0.00678546426476664 0.0340642630849788 1.29806259314456 1 27.3 27 3 abnormal vertebral artery origin 0.00678546426476664 0.0340642630849788 1.29806259314456 1 27.3 27 3 abnormal Wolffian duct connection 0.00678546426476664 0.0340642630849788 1.29806259314456 1 27.3 27 3 decreased hippocampus volume 0.00678546426476664 0.0340642630849788 1.29806259314456 1 27.3 27 3 decreased capillary density 0.00678546426476664 0.0340642630849788 1.29806259314456 1 27.3 27 3 abnormal excitatory synapse morphology 0.00678546426476664 0.0340642630849788 1.29806259314456 1 27.3 27 3 absent neurocranium 0.0155964059359368 0.0627260465087192 1.29806259314456 1 27.3 27 3 abnormal pineal gland morphology 0.0155964059359368 0.0627260465087192 1.29806259314456 1 27.3 27 3 skin hyperplasia 0.0155964059359368 0.0627260465087192 1.29806259314456 1 27.3 27 3 kinked vibrissae 0.0155964059359368 0.0627260465087192 1.29806259314456 1 27.3 27 3 corneal scarring 0.0155964059359368 0.0627260465087192 1.29806259314456 1 27.3 27 3 vascular inflammation 0.0155964059359368 0.0627260465087192 1.29806259314456 1 27.3 27 3 improved righting response 0.0155964059359368 0.0627260465087192 1.29806259314456 1 27.3 27 3 decreased lysosomal enzyme secretion 0.0155964059359368 0.0627260465087192 1.29806259314456 1 27.3 27 3 gastric polyps 0.0155964059359368 0.0627260465087192 1.29806259314456 1 27.3 27 3 epidermal cyst 0.0155964059359368 0.0627260465087192 1.29806259314456 1 27.3 27 3 ischuria 0.0155964059359368 0.0627260465087192 1.29806259314456 1 27.3 27 3 abnormal response to vitamins 0.0155964059359368 0.0627260465087192 1.29806259314456 1 27.3 27 3 ectopic cartilage 0.0155964059359368 0.0627260465087192 1.29806259314456 1 27.3 27 3 increased heart right ventricle weight 0.0155964059359368 0.0627260465087192 1.29806259314456 1 27.3 27 3 abnormal myotome morphology 0.0155964059359368 0.0627260465087192 1.29806259314456 1 27.3 27 3 abnormal tail pigmentation 0.0155964059359368 0.0627260465087192 1.29806259314456 1 27.3 27 3 abnormal mesangial cell morphology 0.0155964059359368 0.0627260465087192 1.29806259314456 1 27.3 27 3 corneal deposits 0.0155964059359368 0.0627260465087192 1.29806259314456 1 27.3 27 3 abnormal optokinetic reflex 0.0155964059359368 0.0627260465087192 1.29806259314456 1 27.3 27 3 increased placenta apoptosis 0.0155964059359368 0.0627260465087192 1.29806259314456 1 27.3 27 3 aciduria 0.0155964059359368 0.0627260465087192 1.29806259314456 1 27.3 27 3 increased response to stress-induced hyperthermia 0.0155964059359368 0.0627260465087192 1.29806259314456 1 27.3 27 3 increased mammary gland epithelial cell proliferation 0.0155964059359368 0.0627260465087192 1.29806259314456 1 27.3 27 3 leptocytosis 0.0155964059359368 0.0627260465087192 1.29806259314456 1 27.3 27 3 abnormal lymphatic vessel endothelial cell morphology 0.0155964059359368 0.0627260465087192 1.29806259314456 1 27.3 27 3 increased thyroid carcinoma incidence 0.0155964059359368 0.0627260465087192 1.29806259314456 1 27.3 27 3 aorta hypoplasia 0.0155964059359368 0.0627260465087192 1.29806259314456 1 27.3 27 3 prolonged ST segment 0.0155964059359368 0.0627260465087192 1.29806259314456 1 27.3 27 3 enlarged aortic valve 0.0155964059359368 0.0627260465087192 1.29806259314456 1 27.3 27 3 increased Schwann cell number 0.0155964059359368 0.0627260465087192 1.29806259314456 1 27.3 27 3 trachea stenosis 0.0155964059359368 0.0627260465087192 1.29806259314456 1 27.3 27 3 pale lung 0.0155964059359368 0.0627260465087192 1.29806259314456 1 27.3 27 3 pulmonary alveolar edema 0.0155964059359368 0.0627260465087192 1.29806259314456 1 27.3 27 3 impaired branching involved in terminal bronchiole morphogenesis 0.0155964059359368 0.0627260465087192 1.29806259314456 1 27.3 27 3 cerebral edema 0.0155964059359368 0.0627260465087192 1.29806259314456 1 27.3 27 3 delayed optic fissure closure 0.0155964059359368 0.0627260465087192 1.29806259314456 1 27.3 27 3 abnormal mitophagy 0.0155964059359368 0.0627260465087192 1.29806259314456 1 27.3 27 3 decreased small intestinal villus height 0.0155964059359368 0.0627260465087192 1.29806259314456 1 27.3 27 3 decreased neuronal precursor proliferation 0.0155964059359368 0.0627260465087192 1.29806259314456 1 27.3 27 3 failure to gastrulate 1.39540592081575e-15 1.05184006909975e-13 1.26984384111968 0.978260869565217 27.3 27 3 increased fibroblast apoptosis 1.14245334640092e-10 4.3820156308779e-09 1.25749813710879 0.96875 27.3 27 3 anencephaly 1.5881159621527e-06 2.57357554127351e-05 1.23315946348733 0.95 27.3 27 3 abnormal hypoglossal nerve topology 7.58911692820603e-06 0.000105463286921299 1.22594800463653 0.944444444444444 27.3 27 3 increased brain size 1.65207648512825e-05 0.000209670421263088 1.22170597001841 0.941176470588235 27.3 27 3 coloboma 1.65207648512825e-05 0.000209670421263088 1.22170597001841 0.941176470588235 27.3 27 3 abnormal olfactory nerve morphology 7.75097299046393e-05 0.000808408608544194 1.21152508693492 0.933333333333333 27.3 27 3 heterochrony 7.75097299046393e-05 0.000808408608544194 1.21152508693492 0.933333333333333 27.3 27 3 absent corpus callosum 5.08049531559814e-08 1.16220433796771e-06 1.20534383649138 0.928571428571429 27.3 27 3 irregularly shaped pupil 0.000166905680708463 0.00157862312076921 1.20534383649138 0.928571428571429 27.3 27 3 lysosomal protein accumulation 0.000166905680708463 0.00157862312076921 1.20534383649138 0.928571428571429 27.3 27 3 spina bifida occulta 0.000166905680708463 0.00157862312076921 1.20534383649138 0.928571428571429 27.3 27 3 decreased cornea thickness 0.000166905680708463 0.00157862312076921 1.20534383649138 0.928571428571429 27.3 27 3 abnormal renal tubule epithelial cell primary cilium morphology 0.000166905680708463 0.00157862312076921 1.20534383649138 0.928571428571429 27.3 27 3 abnormal aorta tunica media morphology 0.000357745472441393 0.0030475748722533 1.19821162444113 0.923076923076923 27.3 27 3 absent hypoglossal nerve 0.000357745472441393 0.0030475748722533 1.19821162444113 0.923076923076923 27.3 27 3 abnormal nursing 1.04838507823204e-06 1.78010776935304e-05 1.18989071038251 0.916666666666667 27.3 27 3 abnormal thymus involution 0.00076271837195519 0.00572326380162454 1.18989071038251 0.916666666666667 27.3 27 3 myocarditis 0.00076271837195519 0.00572326380162454 1.18989071038251 0.916666666666667 27.3 27 3 abnormal embryonic growth/weight/body size 0.00076271837195519 0.00572326380162454 1.18989071038251 0.916666666666667 27.3 27 3 abnormal corticospinal tract morphology 0.00076271837195519 0.00572326380162454 1.18989071038251 0.916666666666667 27.3 27 3 decreased synaptic depression 0.00076271837195519 0.00572326380162454 1.18989071038251 0.916666666666667 27.3 27 3 abnormal vascular endothelial cell development 0.00076271837195519 0.00572326380162454 1.18989071038251 0.916666666666667 27.3 27 3 increased skeletal muscle glycogen level 0.00076271837195519 0.00572326380162454 1.18989071038251 0.916666666666667 27.3 27 3 persistent right dorsal aorta 0.00076271837195519 0.00572326380162454 1.18989071038251 0.916666666666667 27.3 27 3 embryonic lethality between implantation and placentation, incomplete penetrance 0.00076271837195519 0.00572326380162454 1.18989071038251 0.916666666666667 27.3 27 3 abnormal sphenoid bone morphology 0.00161609334174138 0.0108796540935905 1.18005690285869 0.909090909090909 27.3 27 3 decreased atrioventricular cushion size 0.00161609334174138 0.0108796540935905 1.18005690285869 0.909090909090909 27.3 27 3 delayed hepatic development 0.00161609334174138 0.0108796540935905 1.18005690285869 0.909090909090909 27.3 27 3 abnormal eye distance/ position 0.00161609334174138 0.0108796540935905 1.18005690285869 0.909090909090909 27.3 27 3 failure of somite differentiation 0.00161609334174138 0.0108796540935905 1.18005690285869 0.909090909090909 27.3 27 3 abnormal hypothalamus secretion 0.00161609334174138 0.0108796540935905 1.18005690285869 0.909090909090909 27.3 27 3 abnormal dorsal-ventral polarity of the somites 0.00161609334174138 0.0108796540935905 1.18005690285869 0.909090909090909 27.3 27 3 palatal shelf hypoplasia 0.00161609334174138 0.0108796540935905 1.18005690285869 0.909090909090909 27.3 27 3 abnormal palatal shelf elevation 0.00161609334174138 0.0108796540935905 1.18005690285869 0.909090909090909 27.3 27 3 common atrioventricular valve 0.00161609334174138 0.0108796540935905 1.18005690285869 0.909090909090909 27.3 27 3 decreased embryonic cilium length 0.00161609334174138 0.0108796540935905 1.18005690285869 0.909090909090909 27.3 27 3 thin hypoglossal nerve 0.00161609334174138 0.0108796540935905 1.18005690285869 0.909090909090909 27.3 27 3 reduced sympathetic cervical ganglion size 0.00161609334174138 0.0108796540935905 1.18005690285869 0.909090909090909 27.3 27 3 preaxial polydactyly 6.60814492517264e-08 1.45958541755532e-06 1.17244363251767 0.903225806451613 27.3 27 3 abnormal synaptic transmission 1.37692048103578e-07 2.86618384650753e-06 1.1682563338301 0.9 27.3 27 3 decreased paired-pulse facilitation 2.0468680462427e-05 0.000248977225673776 1.1682563338301 0.9 27.3 27 3 abnormal neuron proliferation 2.0468680462427e-05 0.000248977225673776 1.1682563338301 0.9 27.3 27 3 increased skin tumor incidence 2.0468680462427e-05 0.000248977225673776 1.1682563338301 0.9 27.3 27 3 absent ductus venosus valve 2.0468680462427e-05 0.000248977225673776 1.1682563338301 0.9 27.3 27 3 kidney hemorrhage 0.00339942895609157 0.0196881944779459 1.1682563338301 0.9 27.3 27 3 fused cornea and lens 0.00339942895609157 0.0196881944779459 1.1682563338301 0.9 27.3 27 3 impaired social transmission of food preference 0.00339942895609157 0.0196881944779459 1.1682563338301 0.9 27.3 27 3 abnormal tibialis anterior morphology 0.00339942895609157 0.0196881944779459 1.1682563338301 0.9 27.3 27 3 bifid ureter 0.00339942895609157 0.0196881944779459 1.1682563338301 0.9 27.3 27 3 abnormal glial cell physiology 0.00339942895609157 0.0196881944779459 1.1682563338301 0.9 27.3 27 3 abnormal plasma membrane morphology 0.00339942895609157 0.0196881944779459 1.1682563338301 0.9 27.3 27 3 abnormal embryonic erythrocyte morphology 0.00339942895609157 0.0196881944779459 1.1682563338301 0.9 27.3 27 3 abnormal spinal cord dorsal column morphology 0.00339942895609157 0.0196881944779459 1.1682563338301 0.9 27.3 27 3 abnormal hippocampus neuron morphology 0.00339942895609157 0.0196881944779459 1.1682563338301 0.9 27.3 27 3 increased circulating fructosamine level 0.00339942895609157 0.0196881944779459 1.1682563338301 0.9 27.3 27 3 abnormal retinal blood vessel pattern 0.00339942895609157 0.0196881944779459 1.1682563338301 0.9 27.3 27 3 aorta stenosis 0.00339942895609157 0.0196881944779459 1.1682563338301 0.9 27.3 27 3 fusion of atlas and odontoid process 0.00339942895609157 0.0196881944779459 1.1682563338301 0.9 27.3 27 3 abnormal adaptive thermogenesis 0.00339942895609157 0.0196881944779459 1.1682563338301 0.9 27.3 27 3 abnormal blastocyst morphology 4.25491453144262e-05 0.000472504459685871 1.16142442544513 0.894736842105263 27.3 27 3 abnormal somite shape 5.91609763180982e-07 1.07811669297633e-05 1.15898445816479 0.892857142857143 27.3 27 3 hydrops fetalis 9.58375168934711e-16 7.44986947726592e-14 1.1538334161285 0.888888888888889 27.3 27 3 lethality at weaning, complete penetrance 2.65114584022647e-10 9.179909768867e-09 1.1538334161285 0.888888888888889 27.3 27 3 reduced long term depression 1.77398377713091e-08 4.43495944282728e-07 1.1538334161285 0.888888888888889 27.3 27 3 abnormal brain commissure morphology 1.21931652675069e-06 2.02879589317213e-05 1.1538334161285 0.888888888888889 27.3 27 3 decreased circulating fructosamine level 1.21931652675069e-06 2.02879589317213e-05 1.1538334161285 0.888888888888889 27.3 27 3 abnormal mitral valve morphology 8.7973948235895e-05 0.000893204882599138 1.1538334161285 0.888888888888889 27.3 27 3 abnormal metacarpal bone morphology 8.7973948235895e-05 0.000893204882599138 1.1538334161285 0.888888888888889 27.3 27 3 darkened coat color 8.7973948235895e-05 0.000893204882599138 1.1538334161285 0.888888888888889 27.3 27 3 increased gastrointestinal tumor incidence 8.7973948235895e-05 0.000893204882599138 1.1538334161285 0.888888888888889 27.3 27 3 heart hyperplasia 0.00708873623700283 0.0347452835261962 1.1538334161285 0.888888888888889 27.3 27 3 abnormal geniculate ganglion morphology 0.00708873623700283 0.0347452835261962 1.1538334161285 0.888888888888889 27.3 27 3 abnormal kindling response 0.00708873623700283 0.0347452835261962 1.1538334161285 0.888888888888889 27.3 27 3 polycythemia 0.00708873623700283 0.0347452835261962 1.1538334161285 0.888888888888889 27.3 27 3 abnormal NMDA-mediated synaptic currents 0.00708873623700283 0.0347452835261962 1.1538334161285 0.888888888888889 27.3 27 3 genetic imprinting 0.00708873623700283 0.0347452835261962 1.1538334161285 0.888888888888889 27.3 27 3 premature neuronal precursor differentiation 0.00708873623700283 0.0347452835261962 1.1538334161285 0.888888888888889 27.3 27 3 decreased cellular sensitivity to ionizing radiation 0.00708873623700283 0.0347452835261962 1.1538334161285 0.888888888888889 27.3 27 3 abnormal proprioceptive neuron morphology 0.00708873623700283 0.0347452835261962 1.1538334161285 0.888888888888889 27.3 27 3 abnormal posterior eye segment morphology 0.00708873623700283 0.0347452835261962 1.1538334161285 0.888888888888889 27.3 27 3 abnormal optic chiasm morphology 0.00708873623700283 0.0347452835261962 1.1538334161285 0.888888888888889 27.3 27 3 eye opacity 0.00708873623700283 0.0347452835261962 1.1538334161285 0.888888888888889 27.3 27 3 abnormal cerebellar layer morphology 0.00708873623700283 0.0347452835261962 1.1538334161285 0.888888888888889 27.3 27 3 abnormal telomere morphology 0.00708873623700283 0.0347452835261962 1.1538334161285 0.888888888888889 27.3 27 3 iris coloboma 0.00708873623700283 0.0347452835261962 1.1538334161285 0.888888888888889 27.3 27 3 reduced AMPA-mediated synaptic currents 0.00708873623700283 0.0347452835261962 1.1538334161285 0.888888888888889 27.3 27 3 abnormal infrahyoid muscle connection 0.00708873623700283 0.0347452835261962 1.1538334161285 0.888888888888889 27.3 27 3 abnormal coronary sinus connection 0.00708873623700283 0.0347452835261962 1.1538334161285 0.888888888888889 27.3 27 3 symmetric azygos veins 0.00708873623700283 0.0347452835261962 1.1538334161285 0.888888888888889 27.3 27 3 increased cardiac muscle glycogen level 0.00708873623700283 0.0347452835261962 1.1538334161285 0.888888888888889 27.3 27 3 cerebellum atrophy 0.00708873623700283 0.0347452835261962 1.1538334161285 0.888888888888889 27.3 27 3 liver hypoplasia 1.68962192301122e-11 7.71180648346863e-10 1.14828614008942 0.884615384615385 27.3 27 3 abnormal axon guidance 1.11165942150838e-09 3.47830542264415e-08 1.1471250823138 0.883720930232558 27.3 27 3 abnormal dendritic spine morphology 3.44797829574293e-11 1.47876655356216e-09 1.14534934689226 0.882352941176471 27.3 27 3 abnormal vagus nerve morphology 0.000180809304148907 0.00167198194821712 1.14534934689226 0.882352941176471 27.3 27 3 hyperlipidemia 0.000180809304148907 0.00167198194821712 1.14534934689226 0.882352941176471 27.3 27 3 abnormal cranial suture morphology 0.000180809304148907 0.00167198194821712 1.14534934689226 0.882352941176471 27.3 27 3 abnormal embryonic-extraembryonic boundary morphology 0.000180809304148907 0.00167198194821712 1.14534934689226 0.882352941176471 27.3 27 3 failure of primitive streak formation 3.07360233931034e-07 5.99653789728194e-06 1.13580476900149 0.875 27.3 27 3 increased hemangiosarcoma incidence 1.03959412552615e-05 0.000138659001997121 1.13580476900149 0.875 27.3 27 3 abnormal tympanic ring morphology 0.000369136041150681 0.00310736345977096 1.13580476900149 0.875 27.3 27 3 absent mandible 0.000369136041150681 0.00310736345977096 1.13580476900149 0.875 27.3 27 3 bowed radius 0.000369136041150681 0.00310736345977096 1.13580476900149 0.875 27.3 27 3 increased cochlear outer hair cell number 0.000369136041150681 0.00310736345977096 1.13580476900149 0.875 27.3 27 3 dilated respiratory conducting tubes 0.000369136041150681 0.00310736345977096 1.13580476900149 0.875 27.3 27 3 failure of vascular branching 0.0146265415117259 0.0620349906400991 1.13580476900149 0.875 27.3 27 3 pointed snout 0.0146265415117259 0.0620349906400991 1.13580476900149 0.875 27.3 27 3 abnormal cecum morphology 0.0146265415117259 0.0620349906400991 1.13580476900149 0.875 27.3 27 3 enlarged pituitary gland 0.0146265415117259 0.0620349906400991 1.13580476900149 0.875 27.3 27 3 abnormal hypoglossal nerve morphology 0.0146265415117259 0.0620349906400991 1.13580476900149 0.875 27.3 27 3 increased sensitivity to skin irradiation 0.0146265415117259 0.0620349906400991 1.13580476900149 0.875 27.3 27 3 dermal cysts 0.0146265415117259 0.0620349906400991 1.13580476900149 0.875 27.3 27 3 dry eyes 0.0146265415117259 0.0620349906400991 1.13580476900149 0.875 27.3 27 3 absent eyelids 0.0146265415117259 0.0620349906400991 1.13580476900149 0.875 27.3 27 3 abnormal urination 0.0146265415117259 0.0620349906400991 1.13580476900149 0.875 27.3 27 3 abnormal thyroid physiology 0.0146265415117259 0.0620349906400991 1.13580476900149 0.875 27.3 27 3 decreased aerobic running capacity 0.0146265415117259 0.0620349906400991 1.13580476900149 0.875 27.3 27 3 abnormal neuron apoptosis 0.0146265415117259 0.0620349906400991 1.13580476900149 0.875 27.3 27 3 colon polyps 0.0146265415117259 0.0620349906400991 1.13580476900149 0.875 27.3 27 3 increased cardiac output 0.0146265415117259 0.0620349906400991 1.13580476900149 0.875 27.3 27 3 abnormal ovary development 0.0146265415117259 0.0620349906400991 1.13580476900149 0.875 27.3 27 3 abnormal eyelid aperture 0.0146265415117259 0.0620349906400991 1.13580476900149 0.875 27.3 27 3 elevated level of mitotic sister chromatid exchange 0.0146265415117259 0.0620349906400991 1.13580476900149 0.875 27.3 27 3 increased left ventricle systolic pressure 0.0146265415117259 0.0620349906400991 1.13580476900149 0.875 27.3 27 3 abnormal extraembryonic tissue physiology 0.0146265415117259 0.0620349906400991 1.13580476900149 0.875 27.3 27 3 accumulation of giant lysosomes in kidney/renal tubule cells 0.0146265415117259 0.0620349906400991 1.13580476900149 0.875 27.3 27 3 abnormal vertebral body development 0.0146265415117259 0.0620349906400991 1.13580476900149 0.875 27.3 27 3 abnormal olfactory tract morphology 0.0146265415117259 0.0620349906400991 1.13580476900149 0.875 27.3 27 3 craniofacial phenotype 0.0146265415117259 0.0620349906400991 1.13580476900149 0.875 27.3 27 3 abnormal olfactory bulb mitral cell layer morphology 0.0146265415117259 0.0620349906400991 1.13580476900149 0.875 27.3 27 3 increased caudal vertebrae number 0.0146265415117259 0.0620349906400991 1.13580476900149 0.875 27.3 27 3 abnormal hepatic vein morphology 0.0146265415117259 0.0620349906400991 1.13580476900149 0.875 27.3 27 3 pulmonary artery hypoplasia 0.0146265415117259 0.0620349906400991 1.13580476900149 0.875 27.3 27 3 delayed suture closure 0.0146265415117259 0.0620349906400991 1.13580476900149 0.875 27.3 27 3 abnormal stomach position or orientation 0.0146265415117259 0.0620349906400991 1.13580476900149 0.875 27.3 27 3 lung situs inversus 0.0146265415117259 0.0620349906400991 1.13580476900149 0.875 27.3 27 3 abnormal bronchiole epithelium morphology 0.0146265415117259 0.0620349906400991 1.13580476900149 0.875 27.3 27 3 abnormal foramen magnum morphology 0.0146265415117259 0.0620349906400991 1.13580476900149 0.875 27.3 27 3 abnormal bronchus epithelium morphology 0.0146265415117259 0.0620349906400991 1.13580476900149 0.875 27.3 27 3 impaired neuron differentiation 0.0146265415117259 0.0620349906400991 1.13580476900149 0.875 27.3 27 3 increased cornea thickness 0.0146265415117259 0.0620349906400991 1.13580476900149 0.875 27.3 27 3 absent hypoglossal canal 0.0146265415117259 0.0620349906400991 1.13580476900149 0.875 27.3 27 3 increased mammary gland apoptosis 0.0146265415117259 0.0620349906400991 1.13580476900149 0.875 27.3 27 3 decreased white adipose tissue mass 0.0146265415117259 0.0620349906400991 1.13580476900149 0.875 27.3 27 3 embryonic lethality between somite formation and embryo turning, complete penetrance 3.665683582818e-14 2.19720190656862e-12 1.13116883116883 0.871428571428571 27.3 27 3 abnormal object recognition memory 6.21063590353577e-07 1.11143574172987e-05 1.13057064564204 0.870967741935484 27.3 27 3 abnormal postnatal growth/weight/body size 6.21063590353577e-07 1.11143574172987e-05 1.13057064564204 0.870967741935484 27.3 27 3 abnormal apoptosis 3.66698055561872e-11 1.55925027899172e-09 1.12979521995915 0.87037037037037 27.3 27 3 abnormal basicranium morphology 2.10256794316449e-05 0.000252706918793917 1.12875008099527 0.869565217391304 27.3 27 3 abnormal hematopoietic stem cell physiology 2.10256794316449e-05 0.000252706918793917 1.12875008099527 0.869565217391304 27.3 27 3 decreased neuron apoptosis 3.7953045095317e-08 8.99125711186677e-07 1.12726488352028 0.868421052631579 27.3 27 3 abnormal myocardial trabeculae morphology 2.35395460734012e-09 6.97078819733161e-08 1.12498758072529 0.866666666666667 27.3 27 3 absent incisors 0.000747979360933319 0.00568990416000499 1.12498758072529 0.866666666666667 27.3 27 3 no suckling reflex 0.000747979360933319 0.00568990416000499 1.12498758072529 0.866666666666667 27.3 27 3 delayed intramembranous bone ossification 0.000747979360933319 0.00568990416000499 1.12498758072529 0.866666666666667 27.3 27 3 abnormal glial cell morphology 0.000747979360933319 0.00568990416000499 1.12498758072529 0.866666666666667 27.3 27 3 abnormal pericyte morphology 0.000747979360933319 0.00568990416000499 1.12498758072529 0.866666666666667 27.3 27 3 abnormal ear development 0.000747979360933319 0.00568990416000499 1.12498758072529 0.866666666666667 27.3 27 3 abnormal trophectoderm morphology 0.000747979360933319 0.00568990416000499 1.12498758072529 0.866666666666667 27.3 27 3 decreased width of hypertrophic chondrocyte zone 7.61006940871898e-08 1.62992742649702e-06 1.12264872920611 0.864864864864865 27.3 27 3 abnormal lysosome physiology 4.22802028114992e-05 0.000472504459685871 1.12105405771576 0.863636363636364 27.3 27 3 abnormal cochlear sensory epithelium morphology 4.22802028114992e-05 0.000472504459685871 1.12105405771576 0.863636363636364 27.3 27 3 abnormal limb posture 4.22802028114992e-05 0.000472504459685871 1.12105405771576 0.863636363636364 27.3 27 3 abnormal cerebral cortex pyramidal cell morphology 4.22802028114992e-05 0.000472504459685871 1.12105405771576 0.863636363636364 27.3 27 3 increased mortality induced by gamma-irradiation 2.50210055768273e-06 3.83013854599126e-05 1.11901947684876 0.862068965517241 27.3 27 3 absent long term depression 2.50210055768273e-06 3.83013854599126e-05 1.11901947684876 0.862068965517241 27.3 27 3 abnormal scapula morphology 8.4487961224329e-05 0.000866654859981519 1.11262507983819 0.857142857142857 27.3 27 3 abnormal embryonic/fetal subventricular zone morphology 8.4487961224329e-05 0.000866654859981519 1.11262507983819 0.857142857142857 27.3 27 3 abnormal embryonic epiblast morphology 3.02331435866988e-07 5.92164918676482e-06 1.11262507983819 0.857142857142857 27.3 27 3 abnormal hippocampus pyramidal cell morphology 3.02331435866988e-07 5.92164918676482e-06 1.11262507983819 0.857142857142857 27.3 27 3 abnormal brainstem morphology 4.98555710816885e-06 7.23123807963266e-05 1.11262507983819 0.857142857142857 27.3 27 3 subcutaneous edema 4.98555710816885e-06 7.23123807963266e-05 1.11262507983819 0.857142857142857 27.3 27 3 midline facial cleft 0.00150278422283896 0.0103838215397553 1.11262507983819 0.857142857142857 27.3 27 3 abnormal blood flow velocity 0.00150278422283896 0.0103838215397553 1.11262507983819 0.857142857142857 27.3 27 3 increased aggression towards males 0.00150278422283896 0.0103838215397553 1.11262507983819 0.857142857142857 27.3 27 3 increased hemangioma incidence 0.00150278422283896 0.0103838215397553 1.11262507983819 0.857142857142857 27.3 27 3 absent olfactory bulb 0.00150278422283896 0.0103838215397553 1.11262507983819 0.857142857142857 27.3 27 3 abnormal voluntary movement 0.00150278422283896 0.0103838215397553 1.11262507983819 0.857142857142857 27.3 27 3 split sternum 0.00150278422283896 0.0103838215397553 1.11262507983819 0.857142857142857 27.3 27 3 testis degeneration 0.00150278422283896 0.0103838215397553 1.11262507983819 0.857142857142857 27.3 27 3 multiple persisting craniopharyngeal ducts 0.00150278422283896 0.0103838215397553 1.11262507983819 0.857142857142857 27.3 27 3 asymmetric rib joints 0.0297861835715875 0.107727865004577 1.11262507983819 0.857142857142857 27.3 27 3 cellular necrosis 0.0297861835715875 0.107727865004577 1.11262507983819 0.857142857142857 27.3 27 3 maxilla hypoplasia 0.0297861835715875 0.107727865004577 1.11262507983819 0.857142857142857 27.3 27 3 mammary gland hyperplasia 0.0297861835715875 0.107727865004577 1.11262507983819 0.857142857142857 27.3 27 3 abnormal oculomotor nerve morphology 0.0297861835715875 0.107727865004577 1.11262507983819 0.857142857142857 27.3 27 3 decreased Schwann cell number 0.0297861835715875 0.107727865004577 1.11262507983819 0.857142857142857 27.3 27 3 limp posture 0.0297861835715875 0.107727865004577 1.11262507983819 0.857142857142857 27.3 27 3 abnormal circulating alanine transaminase level 0.0297861835715875 0.107727865004577 1.11262507983819 0.857142857142857 27.3 27 3 abnormal axial mesoderm 0.0297861835715875 0.107727865004577 1.11262507983819 0.857142857142857 27.3 27 3 decreased activated T cell number 0.0297861835715875 0.107727865004577 1.11262507983819 0.857142857142857 27.3 27 3 abnormal gastrulation movements 0.0297861835715875 0.107727865004577 1.11262507983819 0.857142857142857 27.3 27 3 decreased mortality induced by ionizing radiation 0.0297861835715875 0.107727865004577 1.11262507983819 0.857142857142857 27.3 27 3 aorta coarctation 0.0297861835715875 0.107727865004577 1.11262507983819 0.857142857142857 27.3 27 3 increased ectoderm apoptosis 0.0297861835715875 0.107727865004577 1.11262507983819 0.857142857142857 27.3 27 3 abnormal organ of Corti supporting cell morphology 0.0297861835715875 0.107727865004577 1.11262507983819 0.857142857142857 27.3 27 3 abnormal vestibular saccular macula morphology 0.0297861835715875 0.107727865004577 1.11262507983819 0.857142857142857 27.3 27 3 increased thyroid-stimulating hormone level 0.0297861835715875 0.107727865004577 1.11262507983819 0.857142857142857 27.3 27 3 decreased tidal volume 0.0297861835715875 0.107727865004577 1.11262507983819 0.857142857142857 27.3 27 3 abnormal sperm annulus morphology 0.0297861835715875 0.107727865004577 1.11262507983819 0.857142857142857 27.3 27 3 decreased DN2 thymocyte number 0.0297861835715875 0.107727865004577 1.11262507983819 0.857142857142857 27.3 27 3 abnormal retina inner limiting membrane morphology 0.0297861835715875 0.107727865004577 1.11262507983819 0.857142857142857 27.3 27 3 coronary fistula 0.0297861835715875 0.107727865004577 1.11262507983819 0.857142857142857 27.3 27 3 abnormal conotruncal ridge morphology 0.0297861835715875 0.107727865004577 1.11262507983819 0.857142857142857 27.3 27 3 abnormal outer hair cell kinocilium morphology 0.0297861835715875 0.107727865004577 1.11262507983819 0.857142857142857 27.3 27 3 abnormal brain ependyma motile cilium physiology 0.0297861835715875 0.107727865004577 1.11262507983819 0.857142857142857 27.3 27 3 embryonic lethality at implantation, incomplete penetrance 0.0297861835715875 0.107727865004577 1.11262507983819 0.857142857142857 27.3 27 3 decreased CD8-positive, naive alpha-beta T cell number 0.0297861835715875 0.107727865004577 1.11262507983819 0.857142857142857 27.3 27 3 fragmented Meckel's cartilage 0.0297861835715875 0.107727865004577 1.11262507983819 0.857142857142857 27.3 27 3 embryo tumor 0.0297861835715875 0.107727865004577 1.11262507983819 0.857142857142857 27.3 27 3 overriding aortic valve 2.30493187361833e-09 6.86648866541989e-08 1.10876179831098 0.854166666666667 27.3 27 3 abnormal cell differentiation 3.69258512919368e-08 8.78976603719548e-07 1.10810221365999 0.853658536585366 27.3 27 3 lung hemorrhage 5.98733430537632e-07 1.07923870178432e-05 1.10717103532918 0.852941176470588 27.3 27 3 abnormal nervous system development 5.98733430537632e-07 1.07923870178432e-05 1.10717103532918 0.852941176470588 27.3 27 3 abnormal direction of heart looping 5.98733430537632e-07 1.07923870178432e-05 1.10717103532918 0.852941176470588 27.3 27 3 abnormal atrioventricular cushion morphology 9.88097993595977e-06 0.00013250101127062 1.10575702378981 0.851851851851852 27.3 27 3 abnormal trigeminal ganglion morphology 9.88097993595977e-06 0.00013250101127062 1.10575702378981 0.851851851851852 27.3 27 3 abnormal eye muscle morphology 9.88097993595977e-06 0.00013250101127062 1.10575702378981 0.851851851851852 27.3 27 3 pulmonary hypoplasia 4.5458853716464e-09 1.24949059248292e-07 1.10473412182516 0.851063829787234 27.3 27 3 abnormal pericardium morphology 0.000167671779475756 0.00158020972350221 1.10335320417288 0.85 27.3 27 3 atrioventricular septal defect 5.63021778920281e-10 1.84278509876868e-08 1.10212861682085 0.849056603773585 27.3 27 3 decreased brown adipose tissue amount 1.18023528775116e-06 1.97699345338788e-05 1.10138644266811 0.848484848484849 27.3 27 3 abnormal nasal bone morphology 1.94709678616178e-05 0.000240367407224686 1.09836065573771 0.846153846153846 27.3 27 3 heart inflammation 1.94709678616178e-05 0.000240367407224686 1.09836065573771 0.846153846153846 27.3 27 3 increased pituitary adenoma incidence 0.00299006931928107 0.0180529063876496 1.09836065573771 0.846153846153846 27.3 27 3 abnormal telomere length 0.00299006931928107 0.0180529063876496 1.09836065573771 0.846153846153846 27.3 27 3 abnormal afterhyperpolarization 0.00299006931928107 0.0180529063876496 1.09836065573771 0.846153846153846 27.3 27 3 small interparietal bone 0.00299006931928107 0.0180529063876496 1.09836065573771 0.846153846153846 27.3 27 3 abnormal exocrine pancreas morphology 0.00299006931928107 0.0180529063876496 1.09836065573771 0.846153846153846 27.3 27 3 abnormal vertebral arch development 0.00299006931928107 0.0180529063876496 1.09836065573771 0.846153846153846 27.3 27 3 increased prostaglandin level 0.00299006931928107 0.0180529063876496 1.09836065573771 0.846153846153846 27.3 27 3 abnormal depression-related behavior 2.31506171503531e-06 3.59919751009395e-05 1.09524031296572 0.84375 27.3 27 3 impaired balance 1.78868751820703e-17 1.779744080616e-15 1.09444493147483 0.843137254901961 27.3 27 3 small lung 2.15668739462743e-09 6.58252747746716e-08 1.09444493147483 0.843137254901961 27.3 27 3 lethality throughout fetal growth and development, complete penetrance 3.46654172238555e-31 9.58113614937117e-29 1.09310534159542 0.842105263157895 27.3 27 3 maternal imprinting 0.000330239563817061 0.00282778283991373 1.09310534159542 0.842105263157895 27.3 27 3 abnormal thyroid gland morphology 3.81310917324728e-05 0.000439125419835769 1.09037257824143 0.84 27.3 27 3 abnormal cranial ganglia morphology 4.5172822684099e-06 6.60984684862919e-05 1.08869765876641 0.838709677419355 27.3 27 3 malocclusion 5.44123912746286e-07 9.95226641879695e-06 1.08756595641842 0.837837837837838 27.3 27 3 abnormal left-right axis patterning 6.6304784797488e-08 1.45958541755532e-06 1.08675007798149 0.837209302325581 27.3 27 3 decreased circulating total protein level 1.00776563902276e-09 3.19339748671225e-08 1.08565235063 0.836363636363636 27.3 27 3 abnormal lung development 3.08776413086206e-14 1.87336909159009e-12 1.08426404839134 0.835294117647059 27.3 27 3 small liver 4.73609935908887e-13 2.56109720776817e-11 1.08171882762047 0.833333333333333 27.3 27 3 absent mesoderm 2.41841040057294e-10 8.59399410203597e-09 1.08171882762047 0.833333333333333 27.3 27 3 abnormal maxilla morphology 1.94671836747767e-09 5.97834807296384e-08 1.08171882762047 0.833333333333333 27.3 27 3 abnormal lysosome morphology 1.05400685936671e-06 1.7835660290304e-05 1.08171882762047 0.833333333333333 27.3 27 3 ocular hypertelorism 7.41743703135621e-05 0.000776878931178888 1.08171882762047 0.833333333333333 27.3 27 3 abnormal redox activity 0.000644986083713961 0.00502160526835204 1.08171882762047 0.833333333333333 27.3 27 3 abnormal anterior eye segment morphology 0.000644986083713961 0.00502160526835204 1.08171882762047 0.833333333333333 27.3 27 3 abnormal eye anterior chamber morphology 0.000644986083713961 0.00502160526835204 1.08171882762047 0.833333333333333 27.3 27 3 increased effector memory CD4-positive, alpha-beta T cell number 0.000644986083713961 0.00502160526835204 1.08171882762047 0.833333333333333 27.3 27 3 abnormal aerobic respiration 0.000644986083713961 0.00502160526835204 1.08171882762047 0.833333333333333 27.3 27 3 abnormal superior cervical ganglion morphology 0.00588296819067234 0.0312054429366644 1.08171882762047 0.833333333333333 27.3 27 3 abnormal glossopharyngeal nerve morphology 0.00588296819067234 0.0312054429366644 1.08171882762047 0.833333333333333 27.3 27 3 absent optic nerve 0.00588296819067234 0.0312054429366644 1.08171882762047 0.833333333333333 27.3 27 3 abnormal mating frequency 0.00588296819067234 0.0312054429366644 1.08171882762047 0.833333333333333 27.3 27 3 impaired embryo implantation 0.00588296819067234 0.0312054429366644 1.08171882762047 0.833333333333333 27.3 27 3 abnormal respiratory function 0.00588296819067234 0.0312054429366644 1.08171882762047 0.833333333333333 27.3 27 3 small thyroid gland 0.00588296819067234 0.0312054429366644 1.08171882762047 0.833333333333333 27.3 27 3 loss of dopaminergic neurons 0.00588296819067234 0.0312054429366644 1.08171882762047 0.833333333333333 27.3 27 3 increased osteosarcoma incidence 0.00588296819067234 0.0312054429366644 1.08171882762047 0.833333333333333 27.3 27 3 abnormal rostral-caudal body axis extension 0.00588296819067234 0.0312054429366644 1.08171882762047 0.833333333333333 27.3 27 3 bowed ulna 0.00588296819067234 0.0312054429366644 1.08171882762047 0.833333333333333 27.3 27 3 decreased cochlear nerve compound action potential 0.00588296819067234 0.0312054429366644 1.08171882762047 0.833333333333333 27.3 27 3 small parietal bone 0.00588296819067234 0.0312054429366644 1.08171882762047 0.833333333333333 27.3 27 3 hematuria 0.00588296819067234 0.0312054429366644 1.08171882762047 0.833333333333333 27.3 27 3 abnormal fatty acid level 0.00588296819067234 0.0312054429366644 1.08171882762047 0.833333333333333 27.3 27 3 abnormal pulmonary valve cusp morphology 0.00588296819067234 0.0312054429366644 1.08171882762047 0.833333333333333 27.3 27 3 prenatal growth retardation 0.00588296819067234 0.0312054429366644 1.08171882762047 0.833333333333333 27.3 27 3 large anterior fontanelle 0.0596511142917877 0.178989320628253 1.08171882762047 0.833333333333333 27.3 27 3 arrest of tooth development 0.0596511142917877 0.178989320628253 1.08171882762047 0.833333333333333 27.3 27 3 hemoglobinuria 0.0596511142917877 0.178989320628253 1.08171882762047 0.833333333333333 27.3 27 3 abnormal urethra morphology 0.0596511142917877 0.178989320628253 1.08171882762047 0.833333333333333 27.3 27 3 epidermal necrosis 0.0596511142917877 0.178989320628253 1.08171882762047 0.833333333333333 27.3 27 3 abnormal lens induction 0.0596511142917877 0.178989320628253 1.08171882762047 0.833333333333333 27.3 27 3 abnormal lacrimal gland physiology 0.0596511142917877 0.178989320628253 1.08171882762047 0.833333333333333 27.3 27 3 hyperresponsive 0.0596511142917877 0.178989320628253 1.08171882762047 0.833333333333333 27.3 27 3 jumpy 0.0596511142917877 0.178989320628253 1.08171882762047 0.833333333333333 27.3 27 3 increased embryo size 0.0596511142917877 0.178989320628253 1.08171882762047 0.833333333333333 27.3 27 3 delayed brain development 0.0596511142917877 0.178989320628253 1.08171882762047 0.833333333333333 27.3 27 3 non-obstructive hydrocephaly 0.0596511142917877 0.178989320628253 1.08171882762047 0.833333333333333 27.3 27 3 abnormal parental behavior 0.0596511142917877 0.178989320628253 1.08171882762047 0.833333333333333 27.3 27 3 chromatolysis 0.0596511142917877 0.178989320628253 1.08171882762047 0.833333333333333 27.3 27 3 decreased posterior semicircular canal size 0.0596511142917877 0.178989320628253 1.08171882762047 0.833333333333333 27.3 27 3 ureter obstruction 0.0596511142917877 0.178989320628253 1.08171882762047 0.833333333333333 27.3 27 3 abnormal leukocyte tethering or rolling 0.0596511142917877 0.178989320628253 1.08171882762047 0.833333333333333 27.3 27 3 abnormal milk ejection 0.0596511142917877 0.178989320628253 1.08171882762047 0.833333333333333 27.3 27 3 shortened QT interval 0.0596511142917877 0.178989320628253 1.08171882762047 0.833333333333333 27.3 27 3 abnormal heart left atrium morphology 0.0596511142917877 0.178989320628253 1.08171882762047 0.833333333333333 27.3 27 3 abnormal physical strength 0.0596511142917877 0.178989320628253 1.08171882762047 0.833333333333333 27.3 27 3 vestibular saccular degeneration 0.0596511142917877 0.178989320628253 1.08171882762047 0.833333333333333 27.3 27 3 short scapula 0.0596511142917877 0.178989320628253 1.08171882762047 0.833333333333333 27.3 27 3 absent cochlear nerve compound action potential 0.0596511142917877 0.178989320628253 1.08171882762047 0.833333333333333 27.3 27 3 absent parietal bone 0.0596511142917877 0.178989320628253 1.08171882762047 0.833333333333333 27.3 27 3 decreased prostate gland weight 0.0596511142917877 0.178989320628253 1.08171882762047 0.833333333333333 27.3 27 3 abnormal blastocoele morphology 0.0596511142917877 0.178989320628253 1.08171882762047 0.833333333333333 27.3 27 3 abnormal heart size 0.0596511142917877 0.178989320628253 1.08171882762047 0.833333333333333 27.3 27 3 decreased triiodothyronine level 0.0596511142917877 0.178989320628253 1.08171882762047 0.833333333333333 27.3 27 3 increased triiodothyronine level 0.0596511142917877 0.178989320628253 1.08171882762047 0.833333333333333 27.3 27 3 abnormal dermis papillary layer morphology 0.0596511142917877 0.178989320628253 1.08171882762047 0.833333333333333 27.3 27 3 abnormal eyelid development 0.0596511142917877 0.178989320628253 1.08171882762047 0.833333333333333 27.3 27 3 delayed chorioallantoic fusion 0.0596511142917877 0.178989320628253 1.08171882762047 0.833333333333333 27.3 27 3 absent sperm mitochondrial sheath 0.0596511142917877 0.178989320628253 1.08171882762047 0.833333333333333 27.3 27 3 abnormal orbit morphology 0.0596511142917877 0.178989320628253 1.08171882762047 0.833333333333333 27.3 27 3 enlarged lymphatic vessel 0.0596511142917877 0.178989320628253 1.08171882762047 0.833333333333333 27.3 27 3 abnormal epiglottis morphology 0.0596511142917877 0.178989320628253 1.08171882762047 0.833333333333333 27.3 27 3 abnormal heart right ventricle outflow tract morphology 0.0596511142917877 0.178989320628253 1.08171882762047 0.833333333333333 27.3 27 3 kidney microaneurysm 0.0596511142917877 0.178989320628253 1.08171882762047 0.833333333333333 27.3 27 3 cerebral arteriovenous malformation 0.0596511142917877 0.178989320628253 1.08171882762047 0.833333333333333 27.3 27 3 thick pulmonary valve cusps 0.0596511142917877 0.178989320628253 1.08171882762047 0.833333333333333 27.3 27 3 abnormal intestinal enteroendocrine cell morphology 0.0596511142917877 0.178989320628253 1.08171882762047 0.833333333333333 27.3 27 3 increased total lung capacity 0.0596511142917877 0.178989320628253 1.08171882762047 0.833333333333333 27.3 27 3 abnormal mandibular prominence morphology 0.0596511142917877 0.178989320628253 1.08171882762047 0.833333333333333 27.3 27 3 decreased macrophage nitric oxide production 0.0596511142917877 0.178989320628253 1.08171882762047 0.833333333333333 27.3 27 3 abnormal endocrine pancreas development 0.0596511142917877 0.178989320628253 1.08171882762047 0.833333333333333 27.3 27 3 abnormal Rathke's pouch development 0.0596511142917877 0.178989320628253 1.08171882762047 0.833333333333333 27.3 27 3 increased bone trabecular spacing 0.0596511142917877 0.178989320628253 1.08171882762047 0.833333333333333 27.3 27 3 absent thymus corticomedullary boundary 0.0596511142917877 0.178989320628253 1.08171882762047 0.833333333333333 27.3 27 3 ciliary body hypoplasia 0.0596511142917877 0.178989320628253 1.08171882762047 0.833333333333333 27.3 27 3 abnormal platelet alpha-granule morphology 0.0596511142917877 0.178989320628253 1.08171882762047 0.833333333333333 27.3 27 3 abnormal embryo morphology 0.0596511142917877 0.178989320628253 1.08171882762047 0.833333333333333 27.3 27 3 increased body fat mass 0.0596511142917877 0.178989320628253 1.08171882762047 0.833333333333333 27.3 27 3 ectopic bone 0.0596511142917877 0.178989320628253 1.08171882762047 0.833333333333333 27.3 27 3 decreased retinal apoptosis 0.0596511142917877 0.178989320628253 1.08171882762047 0.833333333333333 27.3 27 3 enlarged kidney 3.74736660505341e-09 1.06532279200804e-07 1.07763686978039 0.830188679245283 27.3 27 3 abnormal cell nucleus morphology 3.03275812395733e-08 7.32425809062511e-07 1.07711576877953 0.829787234042553 27.3 27 3 thick ventricular wall 2.47098428683956e-07 4.91725873081072e-06 1.07644215041256 0.829268292682927 27.3 27 3 lethality at weaning, incomplete penetrance 2.47098428683956e-07 4.91725873081072e-06 1.07644215041256 0.829268292682927 27.3 27 3 abnormal artery morphology 2.03134307144576e-06 3.19807967735526e-05 1.07553757717692 0.828571428571429 27.3 27 3 decreased triglyceride level 2.03134307144576e-06 3.19807967735526e-05 1.07553757717692 0.828571428571429 27.3 27 3 abnormal embryonic neuroepithelium morphology 8.92865300671957e-10 2.84743901977115e-08 1.07425869777481 0.827586206896552 27.3 27 3 abnormal outer ear morphology 1.69061485505023e-05 0.000213472307204946 1.07425869777481 0.827586206896552 27.3 27 3 blood in lymph vessels 1.69061485505023e-05 0.000213472307204946 1.07425869777481 0.827586206896552 27.3 27 3 abnormal neural tube morphology 8.08793505690819e-25 1.38749920372822e-22 1.07370609556402 0.827160493827161 27.3 27 3 increased neuron apoptosis 4.21140149724229e-13 2.30238708228356e-11 1.07370609556402 0.827160493827161 27.3 27 3 abnormal cranial nerve morphology 0.000143239188865808 0.00138103675311511 1.07231257694551 0.826086956521739 27.3 27 3 abnormal corneal stroma morphology 0.000143239188865808 0.00138103675311511 1.07231257694551 0.826086956521739 27.3 27 3 gliosis 2.13020578126008e-10 7.62429767033732e-09 1.07141674354789 0.825396825396825 27.3 27 3 increased hepatocellular carcinoma incidence 1.70694731521038e-09 5.27457322557246e-08 1.07033231364551 0.824561403508772 27.3 27 3 abnormal axon morphology 9.44597855568024e-17 8.5443169662744e-15 1.0696997295358 0.824074074074074 27.3 27 3 ventricular septal defect 1.13090383686356e-20 1.44262733035801e-18 1.06899272376611 0.823529411764706 27.3 27 3 abnormal interatrial septum morphology 0.00124799414715896 0.00892064781913192 1.06899272376611 0.823529411764706 27.3 27 3 abnormal glutamate-mediated receptor currents 0.00124799414715896 0.00892064781913192 1.06899272376611 0.823529411764706 27.3 27 3 absence seizures 0.00124799414715896 0.00892064781913192 1.06899272376611 0.823529411764706 27.3 27 3 prenatal lethality 4.06135088483583e-10 1.35605507731934e-08 1.06776116532859 0.82258064516129 27.3 27 3 double outlet right ventricle 1.79771317546157e-16 1.56905667507392e-14 1.06756549716562 0.822429906542056 27.3 27 3 ataxia 9.62123841315431e-30 2.1731470284104e-27 1.06672470525741 0.821782178217822 27.3 27 3 abnormal eye development 3.25176812435416e-09 9.35118290096066e-08 1.0662657015116 0.821428571428571 27.3 27 3 abnormal interventricular septum morphology 2.61366398567603e-08 6.34291625792111e-07 1.06441132637854 0.82 27.3 27 3 abnormal axon extension 2.61366398567603e-08 6.34291625792111e-07 1.06441132637854 0.82 27.3 27 3 abnormal head morphology 6.17200564552467e-09 1.66878956991768e-07 1.06205121257282 0.818181818181818 27.3 27 3 abnormal basisphenoid bone morphology 0.000274422874082061 0.00240939053176378 1.06205121257282 0.818181818181818 27.3 27 3 abnormal germ layer development 0.000274422874082061 0.00240939053176378 1.06205121257282 0.818181818181818 27.3 27 3 abnormal vascular branching morphogenesis 0.000274422874082061 0.00240939053176378 1.06205121257282 0.818181818181818 27.3 27 3 cleft upper lip 0.000274422874082061 0.00240939053176378 1.06205121257282 0.818181818181818 27.3 27 3 increased circulating creatine kinase level 0.000274422874082061 0.00240939053176378 1.06205121257282 0.818181818181818 27.3 27 3 premature suture closure 0.0114244392206674 0.0513893174709042 1.06205121257282 0.818181818181818 27.3 27 3 abnormal food preference 0.0114244392206674 0.0513893174709042 1.06205121257282 0.818181818181818 27.3 27 3 abnormal fear/anxiety-related behavior 0.0114244392206674 0.0513893174709042 1.06205121257282 0.818181818181818 27.3 27 3 abnormal bronchiole morphology 0.0114244392206674 0.0513893174709042 1.06205121257282 0.818181818181818 27.3 27 3 fatigue 0.0114244392206674 0.0513893174709042 1.06205121257282 0.818181818181818 27.3 27 3 retinal detachment 0.0114244392206674 0.0513893174709042 1.06205121257282 0.818181818181818 27.3 27 3 abnormal radial glial cell morphology 0.0114244392206674 0.0513893174709042 1.06205121257282 0.818181818181818 27.3 27 3 abnormal pituitary gland development 0.0114244392206674 0.0513893174709042 1.06205121257282 0.818181818181818 27.3 27 3 pharyngeal arch hypoplasia 0.0114244392206674 0.0513893174709042 1.06205121257282 0.818181818181818 27.3 27 3 abnormal spinal cord ventral horn morphology 0.0114244392206674 0.0513893174709042 1.06205121257282 0.818181818181818 27.3 27 3 increased glycogen level 0.0114244392206674 0.0513893174709042 1.06205121257282 0.818181818181818 27.3 27 3 abnormal aorta smooth muscle morphology 0.0114244392206674 0.0513893174709042 1.06205121257282 0.818181818181818 27.3 27 3 abnormal pulmonary alveolar sac morphology 0.0114244392206674 0.0513893174709042 1.06205121257282 0.818181818181818 27.3 27 3 abnormal cell cycle 3.74966372739991e-17 3.65776020466952e-15 1.06102507613555 0.817391304347826 27.3 27 3 embryonic lethality before implantation, complete penetrance 2.17345846240903e-18 2.51464089546161e-16 1.05921907600596 0.816 27.3 27 3 abnormal cell morphology 7.07927544744544e-17 6.64516893415869e-15 1.05894579967056 0.815789473684211 27.3 27 3 embryonic lethality, complete penetrance 1.59464254260437e-44 7.21213331768794e-42 1.05798205083883 0.815047021943574 27.3 27 3 impaired limb coordination 1.16702188503866e-08 2.99274942168419e-07 1.05768063145112 0.814814814814815 27.3 27 3 abnormal trigeminal nerve morphology 6.16669147345136e-05 0.000655540386333772 1.05768063145112 0.814814814814815 27.3 27 3 abnormal skin appearance 6.16669147345136e-05 0.000655540386333772 1.05768063145112 0.814814814814815 27.3 27 3 abnormal vasculogenesis 3.99432527994758e-07 7.49878047839216e-06 1.05656257581534 0.813953488372093 27.3 27 3 delayed endochondral bone ossification 3.99432527994758e-07 7.49878047839216e-06 1.05656257581534 0.813953488372093 27.3 27 3 delayed bone ossification 1.96511057965712e-11 8.88765921254014e-10 1.05575757575758 0.813333333333333 27.3 27 3 abnormal lumbar vertebrae morphology 1.40602379996997e-05 0.000182160635542985 1.05467585692996 0.8125 27.3 27 3 pancreatic islet hyperplasia 1.40602379996997e-05 0.000182160635542985 1.05467585692996 0.8125 27.3 27 3 abnormal auditory brainstem response waveform shape 1.40602379996997e-05 0.000182160635542985 1.05467585692996 0.8125 27.3 27 3 disorganized retinal layers 0.00238963374665809 0.0153201390330206 1.05467585692996 0.8125 27.3 27 3 decreased cochlear coiling 0.00238963374665809 0.0153201390330206 1.05467585692996 0.8125 27.3 27 3 impaired somite development 0.00238963374665809 0.0153201390330206 1.05467585692996 0.8125 27.3 27 3 perinatal lethality, complete penetrance 1.00467098800883e-29 2.1731470284104e-27 1.05429497001882 0.812206572769953 27.3 27 3 abnormal breathing pattern 3.23921948773993e-06 4.85395088900788e-05 1.05248318363072 0.810810810810811 27.3 27 3 abnormal somite development 8.79805935443344e-12 4.29121032238298e-10 1.05159501216775 0.810126582278481 27.3 27 3 abnormal nervous system morphology 8.79805935443344e-12 4.29121032238298e-10 1.05159501216775 0.810126582278481 27.3 27 3 left pulmonary isomerism 0.000521203007044315 0.00420939116890498 1.05081257540274 0.80952380952381 27.3 27 3 absent segment of posterior cerebral artery 0.000521203007044315 0.00420939116890498 1.05081257540274 0.80952380952381 27.3 27 3 abnormal CNS synaptic transmission 2.8705535315021e-14 1.76308689126209e-12 1.04893946920773 0.808080808080808 27.3 27 3 kinked neural tube 4.12247823684606e-08 9.62879306493388e-07 1.04843517138599 0.807692307692308 27.3 27 3 decreased circulating glycerol level 0.000116503611990064 0.00114773360326845 1.04843517138599 0.807692307692308 27.3 27 3 abnormal brain morphology 3.02381195697103e-22 4.42454837821496e-20 1.04812507520989 0.807453416149068 27.3 27 3 abnormal neural tube closure 3.92580130902324e-12 2.01349087756604e-10 1.04783365952633 0.807228915662651 27.3 27 3 decreased brain weight 9.71192787168266e-09 2.52967754772886e-07 1.04755928569561 0.807017543859649 27.3 27 3 pericardial effusion 2.29519062725092e-09 6.86648866541989e-08 1.04682467189077 0.806451612903226 27.3 27 3 abnormal capillary morphology 2.64647205937548e-05 0.000311257647645225 1.04682467189077 0.806451612903226 27.3 27 3 short snout 3.07324847739791e-15 2.15343819366966e-13 1.04566153336645 0.805555555555556 27.3 27 3 abnormal forebrain development 1.29141690801622e-10 4.86727205862173e-09 1.04566153336645 0.805555555555556 27.3 27 3 atrial septal defect 3.28500698820826e-07 6.33446114974266e-06 1.04409382492062 0.804347826086957 27.3 27 3 embryonic lethality between implantation and placentation, complete penetrance 3.28500698820826e-07 6.33446114974266e-06 1.04409382492062 0.804347826086957 27.3 27 3 increased lung adenocarcinoma incidence 7.6991546779256e-08 1.62992742649702e-06 1.04354051605739 0.803921568627451 27.3 27 3 abnormal cervical vertebrae morphology 7.6991546779256e-08 1.62992742649702e-06 1.04354051605739 0.803921568627451 27.3 27 3 abnormal response to novel object 7.6991546779256e-08 1.62992742649702e-06 1.04354051605739 0.803921568627451 27.3 27 3 abnormal long bone morphology 4.27804392833612e-09 1.18900941583643e-07 1.04270601744399 0.80327868852459 27.3 27 3 decreased heart weight 1.36129982442278e-11 6.27080243194752e-10 1.04165516733823 0.802469135802469 27.3 27 3 abnormal nervous system physiology 1.12974112887344e-15 8.6468647940698e-14 1.03845007451565 0.8 27.3 27 3 abnormal erythropoiesis 1.96699785250735e-14 1.270884976133e-12 1.03845007451565 0.8 27.3 27 3 abnormal rostral-caudal axis patterning 3.36630716698341e-08 8.05162411333773e-07 1.03845007451565 0.8 27.3 27 3 perinatal lethality 2.62454057773612e-06 3.98253739282623e-05 1.03845007451565 0.8 27.3 27 3 abnormal liver development 1.13441808212883e-05 0.000150099201026354 1.03845007451565 0.8 27.3 27 3 holoprosencephaly 1.13441808212883e-05 0.000150099201026354 1.03845007451565 0.8 27.3 27 3 abnormal optic cup morphology 4.94700485237661e-05 0.000538541556686512 1.03845007451565 0.8 27.3 27 3 abnormal nest building behavior 0.000218347484637918 0.00199495974036879 1.03845007451565 0.8 27.3 27 3 diaphragmatic hernia 0.000218347484637918 0.00199495974036879 1.03845007451565 0.8 27.3 27 3 increased cellular sensitivity to ionizing radiation 0.000218347484637918 0.00199495974036879 1.03845007451565 0.8 27.3 27 3 abnormal cochlear outer hair cell morphology 0.000218347484637918 0.00199495974036879 1.03845007451565 0.8 27.3 27 3 abnormal basioccipital bone morphology 0.000980510701182289 0.00723744916673871 1.03845007451565 0.8 27.3 27 3 abnormal vascular regression 0.000980510701182289 0.00723744916673871 1.03845007451565 0.8 27.3 27 3 increased mammary adenocarcinoma incidence 0.000980510701182289 0.00723744916673871 1.03845007451565 0.8 27.3 27 3 abnormal fontanelle morphology 0.00452200367046154 0.0249966314006068 1.03845007451565 0.8 27.3 27 3 abnormal pup retrieval 0.00452200367046154 0.0249966314006068 1.03845007451565 0.8 27.3 27 3 decreased aggression towards males 0.00452200367046154 0.0249966314006068 1.03845007451565 0.8 27.3 27 3 abnormal placenta size 0.00452200367046154 0.0249966314006068 1.03845007451565 0.8 27.3 27 3 immune system phenotype 0.00452200367046154 0.0249966314006068 1.03845007451565 0.8 27.3 27 3 abnormal cerebral aqueduct morphology 0.00452200367046154 0.0249966314006068 1.03845007451565 0.8 27.3 27 3 decreased thymocyte apoptosis 0.00452200367046154 0.0249966314006068 1.03845007451565 0.8 27.3 27 3 abnormal secondary palate development 0.00452200367046154 0.0249966314006068 1.03845007451565 0.8 27.3 27 3 abnormal aorta wall morphology 0.00452200367046154 0.0249966314006068 1.03845007451565 0.8 27.3 27 3 ostium primum atrial septal defect 0.00452200367046154 0.0249966314006068 1.03845007451565 0.8 27.3 27 3 abnormal coronary vessel morphology 0.00452200367046154 0.0249966314006068 1.03845007451565 0.8 27.3 27 3 abnormal branching involved in lung morphogenesis 0.00452200367046154 0.0249966314006068 1.03845007451565 0.8 27.3 27 3 abnormal otic capsule morphology 0.0218459653606479 0.0834744068119996 1.03845007451565 0.8 27.3 27 3 retarded hair growth 0.0218459653606479 0.0834744068119996 1.03845007451565 0.8 27.3 27 3 absent maxillary shelf 0.0218459653606479 0.0834744068119996 1.03845007451565 0.8 27.3 27 3 enlarged testis 0.0218459653606479 0.0834744068119996 1.03845007451565 0.8 27.3 27 3 abnormal optic nerve innervation 0.0218459653606479 0.0834744068119996 1.03845007451565 0.8 27.3 27 3 primary sex reversal 0.0218459653606479 0.0834744068119996 1.03845007451565 0.8 27.3 27 3 delayed dark adaptation 0.0218459653606479 0.0834744068119996 1.03845007451565 0.8 27.3 27 3 impaired basement membrane formation 0.0218459653606479 0.0834744068119996 1.03845007451565 0.8 27.3 27 3 acrania 0.0218459653606479 0.0834744068119996 1.03845007451565 0.8 27.3 27 3 lymphedema 0.0218459653606479 0.0834744068119996 1.03845007451565 0.8 27.3 27 3 increased atrioventricular cushion size 0.0218459653606479 0.0834744068119996 1.03845007451565 0.8 27.3 27 3 abnormal pillar cell morphology 0.0218459653606479 0.0834744068119996 1.03845007451565 0.8 27.3 27 3 increased heart rate variability 0.0218459653606479 0.0834744068119996 1.03845007451565 0.8 27.3 27 3 abnormal gas homeostasis 0.0218459653606479 0.0834744068119996 1.03845007451565 0.8 27.3 27 3 abnormal respiratory conducting tube morphology 0.0218459653606479 0.0834744068119996 1.03845007451565 0.8 27.3 27 3 absent coat pigmentation 0.0218459653606479 0.0834744068119996 1.03845007451565 0.8 27.3 27 3 abnormal corneal endothelium morphology 0.0218459653606479 0.0834744068119996 1.03845007451565 0.8 27.3 27 3 osteosclerosis 0.0218459653606479 0.0834744068119996 1.03845007451565 0.8 27.3 27 3 decreased thyroxine level 0.0218459653606479 0.0834744068119996 1.03845007451565 0.8 27.3 27 3 increased platelet aggregation 0.0218459653606479 0.0834744068119996 1.03845007451565 0.8 27.3 27 3 decreased transitional stage T2 B cell number 0.0218459653606479 0.0834744068119996 1.03845007451565 0.8 27.3 27 3 increased serotonin level 0.0218459653606479 0.0834744068119996 1.03845007451565 0.8 27.3 27 3 abnormal heart and great artery attachment 0.0218459653606479 0.0834744068119996 1.03845007451565 0.8 27.3 27 3 thick aortic valve cusps 0.0218459653606479 0.0834744068119996 1.03845007451565 0.8 27.3 27 3 thick aortic valve 0.0218459653606479 0.0834744068119996 1.03845007451565 0.8 27.3 27 3 abnormal pulmonary interalveolar septum morphology 0.0218459653606479 0.0834744068119996 1.03845007451565 0.8 27.3 27 3 abnormal circadian temperature homeostasis 0.0218459653606479 0.0834744068119996 1.03845007451565 0.8 27.3 27 3 increased fatty acid oxidation 0.0218459653606479 0.0834744068119996 1.03845007451565 0.8 27.3 27 3 decreased embryo size 1.65085530140188e-60 1.64260102489487e-57 1.03736382966783 0.799163179916318 27.3 27 3 decreased birth body size 2.08800517886057e-15 1.51091838245247e-13 1.03617277172066 0.798245614035088 27.3 27 3 abnormal embryo size 3.85070186884166e-15 2.66072802742879e-13 1.03385516268151 0.79646017699115 27.3 27 3 abnormal chondrocyte morphology 6.22781354883845e-08 1.39564740565186e-06 1.03364243528178 0.796296296296296 27.3 27 3 abnormal neuronal precursor proliferation 6.22781354883845e-08 1.39564740565186e-06 1.03364243528178 0.796296296296296 27.3 27 3 polydactyly 2.79931173892067e-13 1.54739732234782e-11 1.03315185984975 0.795918367346939 27.3 27 3 embryonic lethality, incomplete penetrance 1.13181779722799e-06 1.90874357329127e-05 1.03254979000135 0.795454545454545 27.3 27 3 astrocytosis 3.6107600687738e-10 1.21375211771282e-08 1.03133740277239 0.794520547945205 27.3 27 3 overexpanded pulmonary alveoli 2.10292792724988e-05 0.000252706918793917 1.03081441220303 0.794117647058823 27.3 27 3 impaired synaptic plasticity 2.10292792724988e-05 0.000252706918793917 1.03081441220303 0.794117647058823 27.3 27 3 abnormal brown adipose tissue morphology 2.10292792724988e-05 0.000252706918793917 1.03081441220303 0.794117647058823 27.3 27 3 lethality throughout fetal growth and development, incomplete penetrance 9.44239887230734e-23 1.42351316332512e-20 1.02974797891915 0.793296089385475 27.3 27 3 abnormal excitatory postsynaptic potential 3.76712989251181e-11 1.58826027247849e-09 1.02895205554142 0.792682926829268 27.3 27 3 embryonic lethality between implantation and somite formation, complete penetrance 2.31700280243899e-30 6.06688891691262e-28 1.02785364518386 0.791836734693877 27.3 27 3 abnormal neuromuscular synapse morphology 6.6307167841105e-10 2.14206597408764e-08 1.02763288623944 0.791666666666667 27.3 27 3 decreased body height 0.000405685499364344 0.00336380893222935 1.02763288623944 0.791666666666667 27.3 27 3 abnormal cardiac muscle contractility 0.000405685499364344 0.00336380893222935 1.02763288623944 0.791666666666667 27.3 27 3 hypopigmentation 0.000405685499364344 0.00336380893222935 1.02763288623944 0.791666666666667 27.3 27 3 abnormal truncus arteriosus septation 0.000405685499364344 0.00336380893222935 1.02763288623944 0.791666666666667 27.3 27 3 kidney failure 2.08424684812588e-06 3.27101831843099e-05 1.02637507364919 0.790697674418605 27.3 27 3 embryonic growth arrest 3.05368292296724e-28 5.84310482375462e-26 1.0259796041885 0.790393013100437 27.3 27 3 increased grooming behavior 8.9520912090862e-06 0.000122353444409901 1.02478625774571 0.789473684210526 27.3 27 3 incomplete somite formation 8.9520912090862e-06 0.000122353444409901 1.02478625774571 0.789473684210526 27.3 27 3 abnormal stationary movement 0.00182528553332733 0.0120434953956279 1.02478625774571 0.789473684210526 27.3 27 3 stereotypic behavior 0.00182528553332733 0.0120434953956279 1.02478625774571 0.789473684210526 27.3 27 3 unresponsive to tactile stimuli 0.00182528553332733 0.0120434953956279 1.02478625774571 0.789473684210526 27.3 27 3 increased malignant tumor incidence 0.00182528553332733 0.0120434953956279 1.02478625774571 0.789473684210526 27.3 27 3 abnormal nasal septum morphology 0.00182528553332733 0.0120434953956279 1.02478625774571 0.789473684210526 27.3 27 3 abnormal neural crest cell migration 0.00182528553332733 0.0120434953956279 1.02478625774571 0.789473684210526 27.3 27 3 abnormal metatarsal bone morphology 0.00182528553332733 0.0120434953956279 1.02478625774571 0.789473684210526 27.3 27 3 right-sided stomach 0.00182528553332733 0.0120434953956279 1.02478625774571 0.789473684210526 27.3 27 3 embryonic lethality between implantation and somite formation, incomplete penetrance 0.00182528553332733 0.0120434953956279 1.02478625774571 0.789473684210526 27.3 27 3 pallor 1.05902721264221e-21 1.50533153797001e-19 1.02361507345114 0.788571428571429 27.3 27 3 abnormal placenta vasculature 2.10304032310401e-07 4.27045943160916e-06 1.02347242921013 0.788461538461538 27.3 27 3 abnormal neuron morphology 7.5569584270707e-13 4.04256647039535e-11 1.02271598247753 0.787878787878788 27.3 27 3 belly spot 3.8717365343847e-05 0.000441786450884493 1.02271598247753 0.787878787878788 27.3 27 3 abnormal locomotor coordination 3.8717365343847e-05 0.000441786450884493 1.02271598247753 0.787878787878788 27.3 27 3 abnormal middle ear ossicle morphology 3.8717365343847e-05 0.000441786450884493 1.02271598247753 0.787878787878788 27.3 27 3 increased cellular sensitivity to gamma-irradiation 8.94005401496423e-07 1.54971319597376e-05 1.02187906268827 0.787234042553192 27.3 27 3 anophthalmia 1.31449970624499e-11 6.11180938184002e-10 1.02094810696763 0.786516853932584 27.3 27 3 abnormal cartilage morphology 3.81655860597429e-06 5.61756777062784e-05 1.01990632318501 0.785714285714286 27.3 27 3 abnormal pancreas morphology 3.81655860597429e-06 5.61756777062784e-05 1.01990632318501 0.785714285714286 27.3 27 3 spina bifida 3.81655860597429e-06 5.61756777062784e-05 1.01990632318501 0.785714285714286 27.3 27 3 myoclonus 0.000168979210633804 0.00158020972350221 1.01990632318501 0.785714285714286 27.3 27 3 lymphoid hyperplasia 0.000168979210633804 0.00158020972350221 1.01990632318501 0.785714285714286 27.3 27 3 small superior cervical ganglion 0.000168979210633804 0.00158020972350221 1.01990632318501 0.785714285714286 27.3 27 3 hypoxia 0.000168979210633804 0.00158020972350221 1.01990632318501 0.785714285714286 27.3 27 3 increased triglyceride level 0.000168979210633804 0.00158020972350221 1.01990632318501 0.785714285714286 27.3 27 3 abnormal interparietal bone morphology 0.00844344800623544 0.0398540358928096 1.01990632318501 0.785714285714286 27.3 27 3 abnormal placing response 0.00844344800623544 0.0398540358928096 1.01990632318501 0.785714285714286 27.3 27 3 abnormal endplate potential 0.00844344800623544 0.0398540358928096 1.01990632318501 0.785714285714286 27.3 27 3 increased lactate dehydrogenase level 0.00844344800623544 0.0398540358928096 1.01990632318501 0.785714285714286 27.3 27 3 intestinal obstruction 0.00844344800623544 0.0398540358928096 1.01990632318501 0.785714285714286 27.3 27 3 abnormal maternal decidual layer morphology 0.00844344800623544 0.0398540358928096 1.01990632318501 0.785714285714286 27.3 27 3 decreased CNS synapse formation 0.00844344800623544 0.0398540358928096 1.01990632318501 0.785714285714286 27.3 27 3 increased pulmonary respiratory rate 0.00844344800623544 0.0398540358928096 1.01990632318501 0.785714285714286 27.3 27 3 increased stomach tumor incidence 0.00844344800623544 0.0398540358928096 1.01990632318501 0.785714285714286 27.3 27 3 abnormal vitelline vein topology 0.00844344800623544 0.0398540358928096 1.01990632318501 0.785714285714286 27.3 27 3 edema 6.38729181660931e-21 8.3623096809556e-19 1.01882819810765 0.784883720930233 27.3 27 3 distended abdomen 3.8372254952321e-07 7.28633467128995e-06 1.01808830834867 0.784313725490196 27.3 27 3 abnormal behavior 8.52629216170433e-33 2.65114396902994e-30 1.0179051989407 0.784172661870504 27.3 27 3 abnormal suckling behavior 2.3893603415541e-11 1.06134533028854e-09 1.01779907871562 0.784090909090909 27.3 27 3 abnormal vocalization 1.63792509831083e-05 0.00020894044523324 1.01740041084303 0.783783783783784 27.3 27 3 abnormal chromosome morphology 1.63792509831083e-05 0.00020894044523324 1.01740041084303 0.783783783783784 27.3 27 3 intracranial hemorrhage 3.90914986339069e-08 9.18171839256637e-07 1.01681569796324 0.783333333333333 27.3 27 3 embryonic lethality during organogenesis, incomplete penetrance 3.90424338094047e-27 7.19392993339958e-25 1.01587507289574 0.782608695652174 27.3 27 3 abnormal vitelline vasculature morphology 2.7522623572623e-14 1.7115631534225e-12 1.01587507289574 0.782608695652174 27.3 27 3 microcephaly 4.01956879429143e-09 1.13621333815908e-07 1.01587507289574 0.782608695652174 27.3 27 3 abnormal cell death 1.62947640962102e-06 2.62350975335424e-05 1.01587507289574 0.782608695652174 27.3 27 3 abnormal myelin sheath morphology 1.62947640962102e-06 2.62350975335424e-05 1.01587507289574 0.782608695652174 27.3 27 3 abnormal cochlear ganglion morphology 0.000746684140860574 0.00568990416000499 1.01587507289574 0.782608695652174 27.3 27 3 decreased effector memory CD8-positive, alpha-beta T cell number 0.000746684140860574 0.00568990416000499 1.01587507289574 0.782608695652174 27.3 27 3 preweaning lethality, incomplete penetrance 3.88545664719426e-47 2.14779409108794e-44 1.01559909488083 0.78239608801956 27.3 27 3 abnormal excitatory postsynaptic currents 4.16129051057742e-10 1.38016135267485e-08 1.01515151515152 0.782051282051282 27.3 27 3 abnormal contextual conditioning behavior 1.64815447504856e-07 3.40231058645916e-06 1.01484893645847 0.781818181818182 27.3 27 3 palatal shelves fail to meet at midline 6.9473706357174e-06 9.7636070374842e-05 1.01312202391771 0.780487804878049 27.3 27 3 short stride length 6.96649259289017e-07 1.23339148219319e-05 1.01248882265276 0.78 27.3 27 3 increased B cell derived lymphoma incidence 6.96649259289017e-07 1.23339148219319e-05 1.01248882265276 0.78 27.3 27 3 decreased circulating alanine transaminase level 7.27449354408433e-09 1.95581889919262e-07 1.0117252564215 0.779411764705882 27.3 27 3 preweaning lethality, complete penetrance 1.26861428514256e-82 2.10378535619475e-79 1.0103838562855 0.778378378378378 27.3 27 3 axon degeneration 2.98211475026282e-07 5.88730987403077e-06 1.00960423911244 0.777777777777778 27.3 27 3 abnormal pharyngeal arch morphology 2.97677378705909e-05 0.000348457637426329 1.00960423911244 0.777777777777778 27.3 27 3 increased brain weight 0.000308432052384488 0.00267325690002235 1.00960423911244 0.777777777777778 27.3 27 3 abnormal fetal cardiomyocyte proliferation 0.000308432052384488 0.00267325690002235 1.00960423911244 0.777777777777778 27.3 27 3 thick interventricular septum 0.000308432052384488 0.00267325690002235 1.00960423911244 0.777777777777778 27.3 27 3 delayed kidney development 0.00335852236921646 0.0196881944779459 1.00960423911244 0.777777777777778 27.3 27 3 right pulmonary isomerism 0.00335852236921646 0.0196881944779459 1.00960423911244 0.777777777777778 27.3 27 3 absent spleen 0.00335852236921646 0.0196881944779459 1.00960423911244 0.777777777777778 27.3 27 3 abnormal phrenic nerve morphology 0.00335852236921646 0.0196881944779459 1.00960423911244 0.777777777777778 27.3 27 3 decreased cellular sensitivity to gamma-irradiation 0.00335852236921646 0.0196881944779459 1.00960423911244 0.777777777777778 27.3 27 3 increased circulating renin level 0.00335852236921646 0.0196881944779459 1.00960423911244 0.777777777777778 27.3 27 3 abnormal body wall morphology 0.00335852236921646 0.0196881944779459 1.00960423911244 0.777777777777778 27.3 27 3 abnormal neutrophil morphology 0.00335852236921646 0.0196881944779459 1.00960423911244 0.777777777777778 27.3 27 3 decreased lactate dehydrogenase level 0.00335852236921646 0.0196881944779459 1.00960423911244 0.777777777777778 27.3 27 3 increased effector memory CD8-positive, alpha-beta T cell number 0.00335852236921646 0.0196881944779459 1.00960423911244 0.777777777777778 27.3 27 3 distorted hair follicle pattern 0.0410088599732565 0.132738502515908 1.00960423911244 0.777777777777778 27.3 27 3 abnormal head movements 0.0410088599732565 0.132738502515908 1.00960423911244 0.777777777777778 27.3 27 3 abnormal urinary bladder urothelium morphology 0.0410088599732565 0.132738502515908 1.00960423911244 0.777777777777778 27.3 27 3 abnormal sympathetic neuron morphology 0.0410088599732565 0.132738502515908 1.00960423911244 0.777777777777778 27.3 27 3 small geniculate ganglion 0.0410088599732565 0.132738502515908 1.00960423911244 0.777777777777778 27.3 27 3 small nodose ganglion 0.0410088599732565 0.132738502515908 1.00960423911244 0.777777777777778 27.3 27 3 abnormal ion homeostasis 0.0410088599732565 0.132738502515908 1.00960423911244 0.777777777777778 27.3 27 3 decreased level of surface class I molecules 0.0410088599732565 0.132738502515908 1.00960423911244 0.777777777777778 27.3 27 3 increased pheochromocytoma incidence 0.0410088599732565 0.132738502515908 1.00960423911244 0.777777777777778 27.3 27 3 abnormal germ cell morphology 0.0410088599732565 0.132738502515908 1.00960423911244 0.777777777777778 27.3 27 3 abnormal vomeronasal organ morphology 0.0410088599732565 0.132738502515908 1.00960423911244 0.777777777777778 27.3 27 3 abnormal posterior semicircular canal morphology 0.0410088599732565 0.132738502515908 1.00960423911244 0.777777777777778 27.3 27 3 premature bone ossification 0.0410088599732565 0.132738502515908 1.00960423911244 0.777777777777778 27.3 27 3 abnormal ovary physiology 0.0410088599732565 0.132738502515908 1.00960423911244 0.777777777777778 27.3 27 3 abnormal thymus physiology 0.0410088599732565 0.132738502515908 1.00960423911244 0.777777777777778 27.3 27 3 decreased vestibular hair cell number 0.0410088599732565 0.132738502515908 1.00960423911244 0.777777777777778 27.3 27 3 abnormal stria vascularis vasculature morphology 0.0410088599732565 0.132738502515908 1.00960423911244 0.777777777777778 27.3 27 3 short frontal bone 0.0410088599732565 0.132738502515908 1.00960423911244 0.777777777777778 27.3 27 3 abnormal inguinal fat pad morphology 0.0410088599732565 0.132738502515908 1.00960423911244 0.777777777777778 27.3 27 3 decreased susceptibility to atherosclerosis 0.0410088599732565 0.132738502515908 1.00960423911244 0.777777777777778 27.3 27 3 abnormal leukopoiesis 0.0410088599732565 0.132738502515908 1.00960423911244 0.777777777777778 27.3 27 3 abnormal hyoid bone lesser horn morphology 0.0410088599732565 0.132738502515908 1.00960423911244 0.777777777777778 27.3 27 3 decreased transitional stage T1 B cell number 0.0410088599732565 0.132738502515908 1.00960423911244 0.777777777777778 27.3 27 3 retropulsion 0.0410088599732565 0.132738502515908 1.00960423911244 0.777777777777778 27.3 27 3 abnormal ventricle myocardium morphology 0.0410088599732565 0.132738502515908 1.00960423911244 0.777777777777778 27.3 27 3 fusion of atlas and occipital bones 0.0410088599732565 0.132738502515908 1.00960423911244 0.777777777777778 27.3 27 3 decreased effector memory CD4-positive, alpha-beta T cell number 0.0410088599732565 0.132738502515908 1.00960423911244 0.777777777777778 27.3 27 3 increased myeloid cell number 0.0410088599732565 0.132738502515908 1.00960423911244 0.777777777777778 27.3 27 3 trigeminal neuroma 0.0410088599732565 0.132738502515908 1.00960423911244 0.777777777777778 27.3 27 3 abnormal ductus venosus valve topology 0.0410088599732565 0.132738502515908 1.00960423911244 0.777777777777778 27.3 27 3 decreased bone mineral density of femur 0.0410088599732565 0.132738502515908 1.00960423911244 0.777777777777778 27.3 27 3 enhanced leukocyte tethering or rolling 0.0410088599732565 0.132738502515908 1.00960423911244 0.777777777777778 27.3 27 3 increased endoplasmic reticulum stress 0.0410088599732565 0.132738502515908 1.00960423911244 0.777777777777778 27.3 27 3 decreased platelet dense granule number 0.0410088599732565 0.132738502515908 1.00960423911244 0.777777777777778 27.3 27 3 abnormal eye morphology 1.88841047648033e-16 1.61980036560166e-14 1.0085666191339 0.776978417266187 27.3 27 3 reduced long term potentiation 1.61623088619608e-13 9.03454905486013e-12 1.00831647860336 0.776785714285714 27.3 27 3 abnormal long bone hypertrophic chondrocyte zone 1.25818565605304e-06 2.07267339035227e-05 1.00666078652027 0.775510204081633 27.3 27 3 increased circulating LDL cholesterol level 1.25818565605304e-06 2.07267339035227e-05 1.00666078652027 0.775510204081633 27.3 27 3 increased tumor incidence 1.32602430407208e-14 8.79596121701149e-13 1.00495168501514 0.774193548387097 27.3 27 3 abnormal eyelid morphology 0.000128345458569519 0.00124954727276587 1.00495168501514 0.774193548387097 27.3 27 3 decreased thymus weight 0.000128345458569519 0.00124954727276587 1.00495168501514 0.774193548387097 27.3 27 3 abnormal podocyte morphology 0.000128345458569519 0.00124954727276587 1.00495168501514 0.774193548387097 27.3 27 3 abnormal nervous system electrophysiology 2.52894764702787e-10 8.9230599602579e-09 1.00445319707615 0.773809523809524 27.3 27 3 abnormal spatial learning 1.28307387857632e-18 1.51983155855171e-16 1.00341034807494 0.773006134969325 27.3 27 3 decreased cell proliferation 6.24604937694183e-21 8.3623096809556e-19 1.00336730172796 0.772972972972973 27.3 27 3 omphalocele 5.32250562117867e-06 7.63096987474464e-05 1.00304836742989 0.772727272727273 27.3 27 3 abnormal tail movements 0.00136025545911598 0.00955829224449437 1.00304836742989 0.772727272727273 27.3 27 3 intracerebral hemorrhage 0.00136025545911598 0.00955829224449437 1.00304836742989 0.772727272727273 27.3 27 3 abnormal occipital bone morphology 0.00136025545911598 0.00955829224449437 1.00304836742989 0.772727272727273 27.3 27 3 increased adenoma incidence 0.00136025545911598 0.00955829224449437 1.00304836742989 0.772727272727273 27.3 27 3 embryonic lethality before implantation, incomplete penetrance 0.00136025545911598 0.00955829224449437 1.00304836742989 0.772727272727273 27.3 27 3 abnormal placenta morphology 1.04901080959144e-09 3.30305618842873e-08 1.00230149597238 0.772151898734177 27.3 27 3 abnormal craniofacial bone morphology 2.29487741690193e-07 4.62227333971138e-06 1.0020132297958 0.771929824561403 27.3 27 3 increased circulating alkaline phosphatase level 2.29288752570155e-18 2.59252623644664e-16 1.00159150705599 0.771604938271605 27.3 27 3 increased carcinoma incidence 5.37164865453344e-05 0.000579695272371017 1.00136257185438 0.771428571428571 27.3 27 3 decreased glycogen level 5.37164865453344e-05 0.000579695272371017 1.00136257185438 0.771428571428571 27.3 27 3 impaired adaptive thermogenesis 5.37164865453344e-05 0.000579695272371017 1.00136257185438 0.771428571428571 27.3 27 3 vertebral transformation 2.26000503408496e-06 3.52461600143344e-05 1.00058991554893 0.770833333333333 27.3 27 3 kidney cysts 4.35191123562148e-09 1.20281991095649e-07 0.999859024449188 0.77027027027027 27.3 27 3 decreased body length 8.61069572460637e-30 2.03991482047222e-27 0.999602945815702 0.77007299270073 27.3 27 3 prenatal lethality, incomplete penetrance 7.81209670769283e-33 2.59101207471812e-30 0.999166601302063 0.769736842105263 27.3 27 3 distended pericardium 9.61784273565906e-07 1.65518565083284e-05 0.998509687034277 0.769230769230769 27.3 27 3 thick skin 0.000557827060130766 0.00440462195441066 0.998509687034277 0.769230769230769 27.3 27 3 abnormal Mullerian duct morphology 0.000557827060130766 0.00440462195441066 0.998509687034277 0.769230769230769 27.3 27 3 increased thymocyte apoptosis 0.000557827060130766 0.00440462195441066 0.998509687034277 0.769230769230769 27.3 27 3 short premaxilla 0.0155259644286432 0.0627260465087192 0.998509687034277 0.769230769230769 27.3 27 3 absent common myeloid progenitor cells 0.0155259644286432 0.0627260465087192 0.998509687034277 0.769230769230769 27.3 27 3 absent myocardial trabeculae 0.0155259644286432 0.0627260465087192 0.998509687034277 0.769230769230769 27.3 27 3 absent trabeculae carneae 0.0155259644286432 0.0627260465087192 0.998509687034277 0.769230769230769 27.3 27 3 increased foot pad pigmentation 0.0155259644286432 0.0627260465087192 0.998509687034277 0.769230769230769 27.3 27 3 abnormal sympathetic ganglion morphology 0.0155259644286432 0.0627260465087192 0.998509687034277 0.769230769230769 27.3 27 3 small trigeminal ganglion 0.0155259644286432 0.0627260465087192 0.998509687034277 0.769230769230769 27.3 27 3 excessive scratching 0.0155259644286432 0.0627260465087192 0.998509687034277 0.769230769230769 27.3 27 3 lymphoid hypoplasia 0.0155259644286432 0.0627260465087192 0.998509687034277 0.769230769230769 27.3 27 3 abnormal lung interstitium morphology 0.0155259644286432 0.0627260465087192 0.998509687034277 0.769230769230769 27.3 27 3 abnormal coping response 0.0155259644286432 0.0627260465087192 0.998509687034277 0.769230769230769 27.3 27 3 abnormal GABAergic neuron morphology 0.0155259644286432 0.0627260465087192 0.998509687034277 0.769230769230769 27.3 27 3 tracheoesophageal fistula 0.0155259644286432 0.0627260465087192 0.998509687034277 0.769230769230769 27.3 27 3 increased cochlear inner hair cell number 0.0155259644286432 0.0627260465087192 0.998509687034277 0.769230769230769 27.3 27 3 small pituitary gland 0.0155259644286432 0.0627260465087192 0.998509687034277 0.769230769230769 27.3 27 3 perimembraneous ventricular septal defect 1.80564317777736e-08 4.49153740472119e-07 0.997062571545822 0.768115942028985 27.3 27 3 enhanced long term potentiation 4.10098572035221e-07 7.67007667622266e-06 0.996726634021716 0.767857142857143 27.3 27 3 increased oxygen consumption 3.47642018734124e-10 1.18460208438512e-08 0.996187571483035 0.767441860465116 27.3 27 3 abnormal organ of Corti morphology 9.53318740687398e-06 0.000128879367796734 0.996187571483035 0.767441860465116 27.3 27 3 muscular ventricular septal defect 1.75158722755994e-07 3.58606850086859e-06 0.99518132141083 0.766666666666667 27.3 27 3 delayed eyelid opening 0.000230852988213755 0.00209579127073619 0.99518132141083 0.766666666666667 27.3 27 3 abnormal cellular respiration 0.000230852988213755 0.00209579127073619 0.99518132141083 0.766666666666667 27.3 27 3 decreased circulating LDL cholesterol level 7.49233178860255e-08 1.622616503377e-06 0.993829172876304 0.765625 27.3 27 3 abnormal blood vessel morphology 4.99325820751578e-16 4.0066870294179e-14 0.993689295441698 0.76551724137931 27.3 27 3 enlarged liver sinusoidal spaces 9.62036450757284e-05 0.000968852498485321 0.992636100639958 0.764705882352941 27.3 27 3 abnormal bone marrow cavity morphology 0.00609996244503025 0.0320457372376193 0.992636100639958 0.764705882352941 27.3 27 3 abnormal involuntary movement 0.00609996244503025 0.0320457372376193 0.992636100639958 0.764705882352941 27.3 27 3 abnormal ectoplacental cone morphology 0.00609996244503025 0.0320457372376193 0.992636100639958 0.764705882352941 27.3 27 3 decreased growth hormone level 0.00609996244503025 0.0320457372376193 0.992636100639958 0.764705882352941 27.3 27 3 common atrium 0.00609996244503025 0.0320457372376193 0.992636100639958 0.764705882352941 27.3 27 3 abnormal ductus venosus valve morphology 0.00609996244503025 0.0320457372376193 0.992636100639958 0.764705882352941 27.3 27 3 cochlear inner hair cell degeneration 1.71366106602787e-06 2.74130668922465e-05 0.992636100639958 0.764705882352941 27.3 27 3 decreased rib number 2.65709951098864e-10 9.179909768867e-09 0.991778161054271 0.764044943820225 27.3 27 3 abnormal learning/memory/conditioning 7.29183256249365e-07 1.28641372334773e-05 0.991247798401301 0.763636363636364 27.3 27 3 abnormal definitive hematopoiesis 1.14504931058116e-10 4.3820156308779e-09 0.990994022723266 0.763440860215054 27.3 27 3 persistence of hyaloid vascular system 4.03112102549571e-05 0.000455791525041845 0.990626715820849 0.763157894736842 27.3 27 3 decreased total retina thickness 4.03112102549571e-05 0.000455791525041845 0.990626715820849 0.763157894736842 27.3 27 3 abnormal reproductive system morphology 1.69659691308952e-05 0.000213685307408111 0.989000070967284 0.761904761904762 27.3 27 3 abnormal eye pigmentation 0.00245029532242379 0.0155466493189658 0.989000070967284 0.761904761904762 27.3 27 3 decreased cochlear outer hair cell number 0.00245029532242379 0.0155466493189658 0.989000070967284 0.761904761904762 27.3 27 3 complete atrioventricular septal defect 0.00245029532242379 0.0155466493189658 0.989000070967284 0.761904761904762 27.3 27 3 embryonic lethality at implantation, complete penetrance 0.00245029532242379 0.0155466493189658 0.989000070967284 0.761904761904762 27.3 27 3 increased muscle cell glucose uptake 0.00245029532242379 0.0155466493189658 0.989000070967284 0.761904761904762 27.3 27 3 abnormal embryonic tissue morphology 6.75553487744363e-16 5.33472793893366e-14 0.989000070967284 0.761904761904762 27.3 27 3 abnormal cranium morphology 1.4685491902529e-14 9.61320029145812e-13 0.988077496274218 0.761194029850746 27.3 27 3 rib fusion 5.67871452947862e-08 1.28416385382528e-06 0.988077496274218 0.761194029850746 27.3 27 3 abnormal locomotor behavior 2.02136487027788e-10 7.34035783184852e-09 0.987656320870861 0.760869565217391 27.3 27 3 embryonic lethality during organogenesis, complete penetrance 3.02126762705951e-56 2.1472580635173e-53 0.987454758356398 0.760714285714286 27.3 27 3 decreased circulating alkaline phosphatase level 3.03638424580576e-06 4.56374973501017e-05 0.986527570789866 0.76 27.3 27 3 abnormal egg cylinder morphology 0.000998922545998025 0.00735153796795884 0.986527570789866 0.76 27.3 27 3 abnormal vertebrae development 0.000998922545998025 0.00735153796795884 0.986527570789866 0.76 27.3 27 3 prenatal lethality, complete penetrance 2.89214350580585e-28 5.75536557655364e-26 0.985220169616914 0.758992805755396 27.3 27 3 abnormal parietal bone morphology 0.000411565278635556 0.00339558418111425 0.984737139626908 0.758620689655172 27.3 27 3 microphthalmia 3.91555410740833e-16 3.19342322694368e-14 0.984152031403719 0.758169934640523 27.3 27 3 decreased birth weight 1.53127461515177e-10 5.64303052620746e-09 0.983794807435877 0.757894736842105 27.3 27 3 abnormal motor coordination/ balance 6.59661696983174e-11 2.64662656652524e-09 0.983380752382243 0.757575757575758 27.3 27 3 decreased circulating serum albumin level 6.59661696983174e-11 2.64662656652524e-09 0.983380752382243 0.757575757575758 27.3 27 3 hemorrhage 6.8070476174278e-24 1.12883539655678e-21 0.98321336842439 0.757446808510638 27.3 27 3 abnormal craniofacial morphology 2.84328102562228e-11 1.25179850464344e-09 0.982998856944424 0.757281553398058 27.3 27 3 domed cranium 4.28051234648692e-08 9.95119108587497e-07 0.982818820523738 0.757142857142857 27.3 27 3 abnormal hepatocyte morphology 5.28955995475387e-12 2.65813745201015e-10 0.982317638055343 0.756756756756757 27.3 27 3 abnormal angiogenesis 1.8336706267664e-08 4.53856286973275e-07 0.982317638055343 0.756756756756757 27.3 27 3 absent gastric milk in neonates 7.86381314117353e-09 2.06997197763695e-07 0.981867858917039 0.756410256410256 27.3 27 3 cleft palate 7.94542633554986e-14 4.54350528958167e-12 0.980978600926042 0.755725190839695 27.3 27 3 trabecula carnea hypoplasia 1.26447171939658e-05 0.000165545968526263 0.980758403709223 0.755555555555556 27.3 27 3 irregular heartbeat 1.26447171939658e-05 0.000165545968526263 0.980758403709223 0.755555555555556 27.3 27 3 cleft secondary palate 2.68384768933202e-10 9.20837396857021e-09 0.980451533119828 0.75531914893617 27.3 27 3 abnormal extraembryonic tissue morphology 4.97875967641851e-11 2.06411078251517e-09 0.979909996785599 0.754901960784314 27.3 27 3 abnormal facial morphology 9.64831836666379e-07 1.65518565083284e-05 0.979240201845896 0.754385964912281 27.3 27 3 neonatal lethality, incomplete penetrance 1.03551303027889e-25 1.83988475915624e-23 0.978539493293592 0.753846153846154 27.3 27 3 abnormal sternum morphology 7.5015436337027e-08 1.622616503377e-06 0.978250070195901 0.753623188405797 27.3 27 3 kyphosis 2.09554509325066e-15 1.51091838245247e-13 0.977873820168902 0.753333333333333 27.3 27 3 limb grasping 2.57266577973757e-18 2.78239396830313e-16 0.977113050883543 0.752747252747253 27.3 27 3 abnormal brain wave pattern 3.96929144341381e-06 5.82514009763531e-05 0.97354694485842 0.75 27.3 27 3 abnormal embryo development 7.85225545786704e-14 4.54243847708006e-12 0.97354694485842 0.75 27.3 27 3 abnormal coat/hair pigmentation 1.21143189872769e-11 5.68572990204742e-10 0.97354694485842 0.75 27.3 27 3 retinal degeneration 3.51254173324861e-10 1.18876837570829e-08 0.97354694485842 0.75 27.3 27 3 abnormal social investigation 1.02897114431495e-08 2.66621429321191e-07 0.97354694485842 0.75 27.3 27 3 pericardial edema 1.30879152041158e-07 2.74479331600477e-06 0.97354694485842 0.75 27.3 27 3 small heart 9.36587464258774e-06 0.000126962469610011 0.97354694485842 0.75 27.3 27 3 curly tail 9.36587464258774e-06 0.000126962469610011 0.97354694485842 0.75 27.3 27 3 cochlear hair cell degeneration 2.21652327639603e-05 0.000264441326140773 0.97354694485842 0.75 27.3 27 3 abnormal retinal blood vessel morphology 0.000125562732569564 0.0012345347718055 0.97354694485842 0.75 27.3 27 3 abnormal vertebral body morphology 0.000301082501846221 0.00262326698193511 0.97354694485842 0.75 27.3 27 3 scoliosis 0.000301082501846221 0.00262326698193511 0.97354694485842 0.75 27.3 27 3 neonatal lethality 0.000301082501846221 0.00262326698193511 0.97354694485842 0.75 27.3 27 3 rib bifurcation 0.00072679057763654 0.00562330190317541 0.97354694485842 0.75 27.3 27 3 straub tail 0.00072679057763654 0.00562330190317541 0.97354694485842 0.75 27.3 27 3 premature aging 0.00072679057763654 0.00562330190317541 0.97354694485842 0.75 27.3 27 3 abnormal sensory capabilities/reflexes/nociception 0.00176968006534927 0.0118335461359041 0.97354694485842 0.75 27.3 27 3 abnormal impulse conducting system conduction 0.00176968006534927 0.0118335461359041 0.97354694485842 0.75 27.3 27 3 abnormal dopamine level 0.00435961002976248 0.0244521532109 0.97354694485842 0.75 27.3 27 3 decreased myocardial infarction size 0.00435961002976248 0.0244521532109 0.97354694485842 0.75 27.3 27 3 abnormal hyoid bone morphology 0.00435961002976248 0.0244521532109 0.97354694485842 0.75 27.3 27 3 spleen atrophy 0.00435961002976248 0.0244521532109 0.97354694485842 0.75 27.3 27 3 abnormal optic stalk morphology 0.00435961002976248 0.0244521532109 0.97354694485842 0.75 27.3 27 3 abnormal postnatal subventricular zone morphology 0.00435961002976248 0.0244521532109 0.97354694485842 0.75 27.3 27 3 abnormal response to tactile stimuli 0.00435961002976248 0.0244521532109 0.97354694485842 0.75 27.3 27 3 decreased muscle cell glucose uptake 0.00435961002976248 0.0244521532109 0.97354694485842 0.75 27.3 27 3 failure of tooth eruption 0.0109191134418719 0.0497915576290675 0.97354694485842 0.75 27.3 27 3 vasculature congestion 0.0109191134418719 0.0497915576290675 0.97354694485842 0.75 27.3 27 3 abnormal extraembryonic endoderm formation 0.0109191134418719 0.0497915576290675 0.97354694485842 0.75 27.3 27 3 intraventricular hemorrhage 0.0109191134418719 0.0497915576290675 0.97354694485842 0.75 27.3 27 3 increased intestinal adenocarcinoma incidence 0.0109191134418719 0.0497915576290675 0.97354694485842 0.75 27.3 27 3 abnormal epicardium morphology 0.0109191134418719 0.0497915576290675 0.97354694485842 0.75 27.3 27 3 abnormal pulmonary elastic fiber morphology 0.0109191134418719 0.0497915576290675 0.97354694485842 0.75 27.3 27 3 decreased aggression towards mice 0.0109191134418719 0.0497915576290675 0.97354694485842 0.75 27.3 27 3 small pancreas 0.0109191134418719 0.0497915576290675 0.97354694485842 0.75 27.3 27 3 bowed tibia 0.0109191134418719 0.0497915576290675 0.97354694485842 0.75 27.3 27 3 decreased circulating growth hormone level 0.0109191134418719 0.0497915576290675 0.97354694485842 0.75 27.3 27 3 blepharitis 0.0109191134418719 0.0497915576290675 0.97354694485842 0.75 27.3 27 3 dystonia 0.0109191134418719 0.0497915576290675 0.97354694485842 0.75 27.3 27 3 decreased circulating triiodothyronine level 0.0109191134418719 0.0497915576290675 0.97354694485842 0.75 27.3 27 3 impaired behavioral response to addictive substance 0.0109191134418719 0.0497915576290675 0.97354694485842 0.75 27.3 27 3 increased heart left ventricle size 0.0109191134418719 0.0497915576290675 0.97354694485842 0.75 27.3 27 3 decreased fibroblast apoptosis 0.0109191134418719 0.0497915576290675 0.97354694485842 0.75 27.3 27 3 decreased adipocyte glucose uptake 0.0109191134418719 0.0497915576290675 0.97354694485842 0.75 27.3 27 3 abnormal enteric nervous system morphology 0.0280488523106525 0.103981401077121 0.97354694485842 0.75 27.3 27 3 ear inflammation 0.0280488523106525 0.103981401077121 0.97354694485842 0.75 27.3 27 3 altered tumor susceptibility 0.0280488523106525 0.103981401077121 0.97354694485842 0.75 27.3 27 3 increased growth rate 0.0280488523106525 0.103981401077121 0.97354694485842 0.75 27.3 27 3 increased circulating parathyroid hormone level 0.0280488523106525 0.103981401077121 0.97354694485842 0.75 27.3 27 3 small intestinal inflammation 0.0280488523106525 0.103981401077121 0.97354694485842 0.75 27.3 27 3 absent ovary 0.0280488523106525 0.103981401077121 0.97354694485842 0.75 27.3 27 3 abnormal defecation 0.0280488523106525 0.103981401077121 0.97354694485842 0.75 27.3 27 3 decreased prostaglandin level 0.0280488523106525 0.103981401077121 0.97354694485842 0.75 27.3 27 3 decreased mammary gland epithelial cell proliferation 0.0280488523106525 0.103981401077121 0.97354694485842 0.75 27.3 27 3 increased fibrosarcoma incidence 0.0280488523106525 0.103981401077121 0.97354694485842 0.75 27.3 27 3 increased type II pneumocyte number 0.0280488523106525 0.103981401077121 0.97354694485842 0.75 27.3 27 3 abnormal colon goblet cell morphology 0.0280488523106525 0.103981401077121 0.97354694485842 0.75 27.3 27 3 abnormal vitelline vein connection 0.0280488523106525 0.103981401077121 0.97354694485842 0.75 27.3 27 3 abnormal exoccipital bone morphology 0.0752651097511723 0.210361753377574 0.97354694485842 0.75 27.3 27 3 abnormal bone marrow development 0.0752651097511723 0.210361753377574 0.97354694485842 0.75 27.3 27 3 clubfoot 0.0752651097511723 0.210361753377574 0.97354694485842 0.75 27.3 27 3 abnormal vagus ganglion morphology 0.0752651097511723 0.210361753377574 0.97354694485842 0.75 27.3 27 3 abnormal pupil morphology 0.0752651097511723 0.210361753377574 0.97354694485842 0.75 27.3 27 3 unidirectional circling 0.0752651097511723 0.210361753377574 0.97354694485842 0.75 27.3 27 3 poor grooming 0.0752651097511723 0.210361753377574 0.97354694485842 0.75 27.3 27 3 abnormal atrial thrombosis 0.0752651097511723 0.210361753377574 0.97354694485842 0.75 27.3 27 3 abnormal secondary sex determination 0.0752651097511723 0.210361753377574 0.97354694485842 0.75 27.3 27 3 decreased corneal stroma thickness 0.0752651097511723 0.210361753377574 0.97354694485842 0.75 27.3 27 3 hypospadia 0.0752651097511723 0.210361753377574 0.97354694485842 0.75 27.3 27 3 absent tympanic ring 0.0752651097511723 0.210361753377574 0.97354694485842 0.75 27.3 27 3 abnormal cellular cholesterol metabolism 0.0752651097511723 0.210361753377574 0.97354694485842 0.75 27.3 27 3 decreased susceptibility to age related obesity 0.0752651097511723 0.210361753377574 0.97354694485842 0.75 27.3 27 3 liver cysts 0.0752651097511723 0.210361753377574 0.97354694485842 0.75 27.3 27 3 binucleate 0.0752651097511723 0.210361753377574 0.97354694485842 0.75 27.3 27 3 tau protein deposits 0.0752651097511723 0.210361753377574 0.97354694485842 0.75 27.3 27 3 abnormal lateral ganglionic eminence morphology 0.0752651097511723 0.210361753377574 0.97354694485842 0.75 27.3 27 3 thin stria vascularis 0.0752651097511723 0.210361753377574 0.97354694485842 0.75 27.3 27 3 small frontal bone 0.0752651097511723 0.210361753377574 0.97354694485842 0.75 27.3 27 3 abnormal hair follicle melanocyte morphology 0.0752651097511723 0.210361753377574 0.97354694485842 0.75 27.3 27 3 absent interparietal bone 0.0752651097511723 0.210361753377574 0.97354694485842 0.75 27.3 27 3 abnormal NK cell morphology 0.0752651097511723 0.210361753377574 0.97354694485842 0.75 27.3 27 3 abnormal choroid pigmentation 0.0752651097511723 0.210361753377574 0.97354694485842 0.75 27.3 27 3 abnormal canal of Schlemm morphology 0.0752651097511723 0.210361753377574 0.97354694485842 0.75 27.3 27 3 ocular hypertension 0.0752651097511723 0.210361753377574 0.97354694485842 0.75 27.3 27 3 choroidal neovascularization 0.0752651097511723 0.210361753377574 0.97354694485842 0.75 27.3 27 3 abnormal epidermal lamellar body morphology 0.0752651097511723 0.210361753377574 0.97354694485842 0.75 27.3 27 3 impaired behavioral response to alcohol 0.0752651097511723 0.210361753377574 0.97354694485842 0.75 27.3 27 3 abnormal mitotic spindle assembly checkpoint 0.0752651097511723 0.210361753377574 0.97354694485842 0.75 27.3 27 3 abnormal base-excision repair 0.0752651097511723 0.210361753377574 0.97354694485842 0.75 27.3 27 3 abnormal olfactory bulb glomerular layer morphology 0.0752651097511723 0.210361753377574 0.97354694485842 0.75 27.3 27 3 decreased hippocampus pyramidal cell number 0.0752651097511723 0.210361753377574 0.97354694485842 0.75 27.3 27 3 abnormal lateral plate mesoderm morphology 0.0752651097511723 0.210361753377574 0.97354694485842 0.75 27.3 27 3 abnormal brain ependyma morphology 0.0752651097511723 0.210361753377574 0.97354694485842 0.75 27.3 27 3 pleural effusion 0.0752651097511723 0.210361753377574 0.97354694485842 0.75 27.3 27 3 heart right ventricle hypoplasia 0.0752651097511723 0.210361753377574 0.97354694485842 0.75 27.3 27 3 anomalous pulmonary venous connection 0.0752651097511723 0.210361753377574 0.97354694485842 0.75 27.3 27 3 myocardial trabeculae hypoplasia 0.0752651097511723 0.210361753377574 0.97354694485842 0.75 27.3 27 3 increased heart right ventricle size 0.0752651097511723 0.210361753377574 0.97354694485842 0.75 27.3 27 3 abnormal anterior commissure pars posterior morphology 0.0752651097511723 0.210361753377574 0.97354694485842 0.75 27.3 27 3 abnormal pulmonary acinus morphology 0.0752651097511723 0.210361753377574 0.97354694485842 0.75 27.3 27 3 increased aorta wall thickness 0.0752651097511723 0.210361753377574 0.97354694485842 0.75 27.3 27 3 abnormal macrophage activation involved in immune response 0.0752651097511723 0.210361753377574 0.97354694485842 0.75 27.3 27 3 increased cardiac stroke volume 0.0752651097511723 0.210361753377574 0.97354694485842 0.75 27.3 27 3 prolonged PQ interval 0.0752651097511723 0.210361753377574 0.97354694485842 0.75 27.3 27 3 increased testis apoptosis 0.0752651097511723 0.210361753377574 0.97354694485842 0.75 27.3 27 3 retropleural edema 0.0752651097511723 0.210361753377574 0.97354694485842 0.75 27.3 27 3 embryo cyst 0.0752651097511723 0.210361753377574 0.97354694485842 0.75 27.3 27 3 decreased basal metabolism 0.0752651097511723 0.210361753377574 0.97354694485842 0.75 27.3 27 3 impaired coordination 1.19233346842523e-32 3.48932882671502e-30 0.971671131862547 0.748554913294798 27.3 27 3 increased insulin sensitivity 2.54414399705119e-14 1.62270722888842e-12 0.971277604660615 0.748251748251748 27.3 27 3 increased mean corpuscular hemoglobin 2.62365639715544e-10 9.179909768867e-09 0.970269009017146 0.747474747474748 27.3 27 3 short limbs 3.29357846431128e-09 9.41698440226932e-08 0.969816879935591 0.747126436781609 27.3 27 3 pale yolk sac 7.66604089336397e-09 2.02864645981307e-07 0.969637117770635 0.746987951807229 27.3 27 3 hyperactivity 1.72933882930045e-34 6.61804667366903e-32 0.969173418601195 0.746630727762803 27.3 27 3 abnormal ovary morphology 9.7233221842315e-08 2.04972575705728e-06 0.968976301924813 0.746478873239437 27.3 27 3 internal hemorrhage 2.27296462342903e-07 4.59674756160952e-06 0.968703427719821 0.746268656716418 27.3 27 3 decreased susceptibility to hepatic steatosis 5.32111877864868e-07 9.80465404584341e-06 0.968395902822132 0.746031746031746 27.3 27 3 abnormal thoracic vertebrae morphology 1.24777329771627e-06 2.06922405204615e-05 0.968046679633232 0.745762711864407 27.3 27 3 abnormal trophoblast layer morphology 6.90280584823333e-06 9.72845866712772e-05 0.967183892931241 0.745098039215686 27.3 27 3 cyanosis 2.44631641171337e-18 2.70453869961644e-16 0.966786202185792 0.744791666666667 27.3 27 3 abnormal double-strand DNA break repair 3.85886068735022e-05 0.000441786450884493 0.966000069316882 0.744186046511628 27.3 27 3 increased embryonic tissue cell apoptosis 3.08715768778933e-08 7.41961811437292e-07 0.965226030799801 0.743589743589744 27.3 27 3 abnormal heart looping 9.17130133756598e-05 0.000925501504145856 0.965226030799801 0.743589743589744 27.3 27 3 abnormal iris morphology 9.17130133756598e-05 0.000925501504145856 0.965226030799801 0.743589743589744 27.3 27 3 abnormal intestine morphology 7.19903380907899e-08 1.57776181498537e-06 0.964776251661497 0.743243243243243 27.3 27 3 abnormal dermal layer morphology 0.000218944325274645 0.00199495974036879 0.964275069193102 0.742857142857143 27.3 27 3 decreased circulating thyroxine level 0.000218944325274645 0.00199495974036879 0.964275069193102 0.742857142857143 27.3 27 3 abnormal vascular development 3.92872487347e-07 7.43171340133584e-06 0.963713137334598 0.742424242424242 27.3 27 3 osteopetrosis 0.000525562135940936 0.00423086023674135 0.963078698139513 0.741935483870968 27.3 27 3 increased lung adenoma incidence 0.000525562135940936 0.00423086023674135 0.963078698139513 0.741935483870968 27.3 27 3 abnormal muscle physiology 4.21721503537985e-09 1.17868791016937e-07 0.96260821514091 0.741573033707865 27.3 27 3 abnormal bone structure 5.38849347753209e-18 5.58494896890045e-16 0.961776947252187 0.740932642487047 27.3 27 3 increased cell proliferation 5.06691817032487e-06 7.30664286880181e-05 0.961527846773748 0.740740740740741 27.3 27 3 abnormal mandible morphology 5.06691817032487e-06 7.30664286880181e-05 0.961527846773748 0.740740740740741 27.3 27 3 thin epidermis 0.00127038422512013 0.00906766358676132 0.961527846773748 0.740740740740741 27.3 27 3 abnormal liver physiology 5.7861869864016e-10 1.88145622597045e-08 0.960566318926975 0.74 27.3 27 3 respiratory distress 3.53062489145471e-16 2.92747647249786e-14 0.960416253887305 0.739884393063584 27.3 27 3 decreased total body fat amount 8.30989289200757e-30 2.03991482047222e-27 0.959944492535049 0.739520958083832 27.3 27 3 abnormal nasal cavity morphology 0.0030987075275063 0.018551227375865 0.959437568845979 0.739130434782609 27.3 27 3 abnormal vertebral artery topology 0.0030987075275063 0.018551227375865 0.959437568845979 0.739130434782609 27.3 27 3 decreased exploration in new environment 1.68210428791878e-08 4.22649941030097e-07 0.958093818749557 0.738095238095238 27.3 27 3 abnormal optic nerve morphology 6.66990634215082e-05 0.000707522048021329 0.958093818749557 0.738095238095238 27.3 27 3 decreased circulating cholesterol level 8.40597140465919e-17 7.74439032188509e-15 0.957587158877135 0.737704918032787 27.3 27 3 abnormal posture 3.9126116567318e-08 9.18171839256637e-07 0.957321162444113 0.7375 27.3 27 3 hypoactivity 5.20422638234821e-33 1.84935901801303e-30 0.957192044812169 0.737400530503979 27.3 27 3 impaired righting response 2.29713029104442e-09 6.86648866541989e-08 0.956467173895992 0.736842105263158 27.3 27 3 increased bone marrow cell number 0.000158527682397494 0.00151818134527675 0.956467173895992 0.736842105263158 27.3 27 3 hyporesponsive to tactile stimuli 0.000158527682397494 0.00151818134527675 0.956467173895992 0.736842105263158 27.3 27 3 decreased threshold for auditory brainstem response 0.000158527682397494 0.00151818134527675 0.956467173895992 0.736842105263158 27.3 27 3 small superior vagus ganglion 0.00765158550970605 0.0367793603002779 0.956467173895992 0.736842105263158 27.3 27 3 abnormal long term depression 0.00765158550970605 0.0367793603002779 0.956467173895992 0.736842105263158 27.3 27 3 abnormal neurotransmitter level 0.00765158550970605 0.0367793603002779 0.956467173895992 0.736842105263158 27.3 27 3 decreased germ cell number 0.00765158550970605 0.0367793603002779 0.956467173895992 0.736842105263158 27.3 27 3 increased susceptibility to ischemic brain injury 0.00765158550970605 0.0367793603002779 0.956467173895992 0.736842105263158 27.3 27 3 increased liver adenoma incidence 0.00765158550970605 0.0367793603002779 0.956467173895992 0.736842105263158 27.3 27 3 abnormal optic vesicle formation 0.00765158550970605 0.0367793603002779 0.956467173895992 0.736842105263158 27.3 27 3 oliguria 0.00765158550970605 0.0367793603002779 0.956467173895992 0.736842105263158 27.3 27 3 abnormal sternebra morphology 0.00765158550970605 0.0367793603002779 0.956467173895992 0.736842105263158 27.3 27 3 abnormal cochlear inner hair cell morphology 0.00765158550970605 0.0367793603002779 0.956467173895992 0.736842105263158 27.3 27 3 increased circulating VLDL cholesterol level 0.00765158550970605 0.0367793603002779 0.956467173895992 0.736842105263158 27.3 27 3 abnormal behavioral response to xenobiotic 0.00765158550970605 0.0367793603002779 0.956467173895992 0.736842105263158 27.3 27 3 increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 0.00765158550970605 0.0367793603002779 0.956467173895992 0.736842105263158 27.3 27 3 increased grip strength 5.32958681175569e-09 1.45685134002662e-07 0.955716414732808 0.736263736263736 27.3 27 3 abnormal mesoderm development 8.7056928474839e-06 0.00011964315446473 0.955178134578073 0.735849056603774 27.3 27 3 increased width of hypertrophic chondrocyte zone 0.000378464732945805 0.0031805102135226 0.954457789076883 0.735294117647059 27.3 27 3 postnatal lethality 4.05337345820973e-15 2.76240177460183e-13 0.953997809419496 0.734939759036145 27.3 27 3 perinatal lethality, incomplete penetrance 5.36123805455559e-20 6.66803983035351e-18 0.953444205584058 0.734513274336283 27.3 27 3 decreased circulating HDL cholesterol level 5.98310708921697e-12 2.97659577688544e-10 0.953264716840536 0.734375 27.3 27 3 increased sacral vertebrae number 1.15638028158991e-06 1.94357834490197e-05 0.953264716840536 0.734375 27.3 27 3 abnormal incisor morphology 2.70447330503109e-06 4.0895910919543e-05 0.951912568306011 0.733333333333333 27.3 27 3 abnormal microglial cell physiology 0.000908524077295507 0.00675298796868014 0.951912568306011 0.733333333333333 27.3 27 3 liver hemorrhage 0.000908524077295507 0.00675298796868014 0.951912568306011 0.733333333333333 27.3 27 3 macrocytosis 0.0192274199296137 0.0754388124210003 0.951912568306011 0.733333333333333 27.3 27 3 decreased hepatocyte number 0.0192274199296137 0.0754388124210003 0.951912568306011 0.733333333333333 27.3 27 3 abnormal enteric neuron morphology 0.0192274199296137 0.0754388124210003 0.951912568306011 0.733333333333333 27.3 27 3 abnormal seizure response to electrical stimulation 0.0192274199296137 0.0754388124210003 0.951912568306011 0.733333333333333 27.3 27 3 absent chorion 0.0192274199296137 0.0754388124210003 0.951912568306011 0.733333333333333 27.3 27 3 decreased trabecular bone mass 0.0192274199296137 0.0754388124210003 0.951912568306011 0.733333333333333 27.3 27 3 decreased brown adipose tissue mass 0.0192274199296137 0.0754388124210003 0.951912568306011 0.733333333333333 27.3 27 3 abnormal ovarian follicle morphology 4.83466505814448e-05 0.000529789838420017 0.951912568306011 0.733333333333333 27.3 27 3 abnormal ectoderm development 4.83466505814448e-05 0.000529789838420017 0.951912568306011 0.733333333333333 27.3 27 3 atelectasis 3.61929552977548e-07 6.89884875886322e-06 0.950693730190382 0.732394366197183 27.3 27 3 increased circulating free fatty acid level 3.61929552977548e-07 6.89884875886322e-06 0.950693730190382 0.732394366197183 27.3 27 3 decreased liver weight 3.61929552977548e-07 6.89884875886322e-06 0.950693730190382 0.732394366197183 27.3 27 3 abnormal neuron differentiation 1.70359789349577e-10 6.23191141186873e-09 0.950367255695124 0.732142857142857 27.3 27 3 postnatal growth retardation 5.50145232370987e-51 3.42121566380707e-48 0.950215754458763 0.73202614379085 27.3 27 3 abnormal developmental patterning 4.89042011053757e-08 1.1263814837928e-06 0.949801897422849 0.731707317073171 27.3 27 3 liver fibrosis 0.00011441765649319 0.00113166568797937 0.949801897422849 0.731707317073171 27.3 27 3 short ulna 0.00011441765649319 0.00113166568797937 0.949801897422849 0.731707317073171 27.3 27 3 abnormal snout morphology 1.48652020898865e-05 0.000190604073188621 0.948584202682563 0.730769230769231 27.3 27 3 decreased kidney weight 1.48652020898865e-05 0.000190604073188621 0.948584202682563 0.730769230769231 27.3 27 3 abnormal female meiosis 1.48652020898865e-05 0.000190604073188621 0.948584202682563 0.730769230769231 27.3 27 3 ventricular hypoplasia 0.00219618172192344 0.014189615670869 0.948584202682563 0.730769230769231 27.3 27 3 abnormal Schwann cell morphology 0.00219618172192344 0.014189615670869 0.948584202682563 0.730769230769231 27.3 27 3 decreased bone resorption 0.00219618172192344 0.014189615670869 0.948584202682563 0.730769230769231 27.3 27 3 decreased grip strength 6.02667553113773e-19 7.3128562847342e-17 0.948356232434382 0.730593607305936 27.3 27 3 decreased body size 1.24501325584705e-65 1.54848523695977e-62 0.948333949628169 0.730576441102757 27.3 27 3 hydroencephaly 1.24980533258005e-10 4.74639811418761e-09 0.948150068036027 0.730434782608696 27.3 27 3 increased startle reflex 1.54163248962726e-08 3.89320895223127e-07 0.94802324218423 0.730337078651685 27.3 27 3 abnormal long bone metaphysis morphology 0.000271745928401938 0.00240939053176378 0.947234865267652 0.72972972972973 27.3 27 3 seizures 2.11203718170922e-10 7.61404708623434e-09 0.94508065992104 0.728070175438597 27.3 27 3 abnormal heart development 7.6804000784066e-14 4.49529298706739e-12 0.944792393744458 0.727848101265823 27.3 27 3 abnormal bone mineralization 6.69979304866443e-11 2.66651763336844e-09 0.944045522286953 0.727272727272727 27.3 27 3 abnormal motor capabilities/coordination/movement 9.23785671173954e-12 4.4190708789331e-10 0.944045522286953 0.727272727272727 27.3 27 3 abnormal embryo turning 1.07611976642289e-05 0.000143146947538873 0.944045522286953 0.727272727272727 27.3 27 3 abnormal astrocyte morphology 8.23842711656148e-05 0.000852103428376161 0.944045522286953 0.727272727272727 27.3 27 3 lethality, incomplete penetrance 8.23842711656148e-05 0.000852103428376161 0.944045522286953 0.727272727272727 27.3 27 3 abnormal oogenesis 0.0053570682912446 0.0291910347743065 0.944045522286953 0.727272727272727 27.3 27 3 abnormal tracheal cartilage morphology 0.0053570682912446 0.0291910347743065 0.944045522286953 0.727272727272727 27.3 27 3 abnormal retinal layer morphology 0.0053570682912446 0.0291910347743065 0.944045522286953 0.727272727272727 27.3 27 3 prolonged PR interval 0.0053570682912446 0.0291910347743065 0.944045522286953 0.727272727272727 27.3 27 3 abnormal blood-brain barrier function 0.0053570682912446 0.0291910347743065 0.944045522286953 0.727272727272727 27.3 27 3 failure of palatal shelf elevation 0.0053570682912446 0.0291910347743065 0.944045522286953 0.727272727272727 27.3 27 3 increased mammary gland tumor incidence 0.0053570682912446 0.0291910347743065 0.944045522286953 0.727272727272727 27.3 27 3 abnormal ear position 0.0496367017339292 0.156193922281023 0.944045522286953 0.727272727272727 27.3 27 3 abnormal thrombopoiesis 0.0496367017339292 0.156193922281023 0.944045522286953 0.727272727272727 27.3 27 3 enlarged cranium 0.0496367017339292 0.156193922281023 0.944045522286953 0.727272727272727 27.3 27 3 abnormal sebaceous gland morphology 0.0496367017339292 0.156193922281023 0.944045522286953 0.727272727272727 27.3 27 3 abnormal glossopharyngeal ganglion morphology 0.0496367017339292 0.156193922281023 0.944045522286953 0.727272727272727 27.3 27 3 vasculitis 0.0496367017339292 0.156193922281023 0.944045522286953 0.727272727272727 27.3 27 3 abnormal primary sex determination 0.0496367017339292 0.156193922281023 0.944045522286953 0.727272727272727 27.3 27 3 abnormal larynx morphology 0.0496367017339292 0.156193922281023 0.944045522286953 0.727272727272727 27.3 27 3 abnormal vestibular ganglion morphology 0.0496367017339292 0.156193922281023 0.944045522286953 0.727272727272727 27.3 27 3 decreased post-tetanic potentiation 0.0496367017339292 0.156193922281023 0.944045522286953 0.727272727272727 27.3 27 3 abnormal frequency of paradoxical sleep 0.0496367017339292 0.156193922281023 0.944045522286953 0.727272727272727 27.3 27 3 dilated renal glomerular capsule 0.0496367017339292 0.156193922281023 0.944045522286953 0.727272727272727 27.3 27 3 abnormal coronal suture morphology 0.0496367017339292 0.156193922281023 0.944045522286953 0.727272727272727 27.3 27 3 cyclopia 0.0496367017339292 0.156193922281023 0.944045522286953 0.727272727272727 27.3 27 3 increased motor neuron number 0.0496367017339292 0.156193922281023 0.944045522286953 0.727272727272727 27.3 27 3 abnormal palate development 0.0496367017339292 0.156193922281023 0.944045522286953 0.727272727272727 27.3 27 3 aberrant origin of the right subclavian artery 0.0496367017339292 0.156193922281023 0.944045522286953 0.727272727272727 27.3 27 3 aorta dilation 0.0496367017339292 0.156193922281023 0.944045522286953 0.727272727272727 27.3 27 3 abnormal phrenic nerve innervation pattern to diaphragm 0.0496367017339292 0.156193922281023 0.944045522286953 0.727272727272727 27.3 27 3 hypolactation 0.0496367017339292 0.156193922281023 0.944045522286953 0.727272727272727 27.3 27 3 decreased body weight 1.39333319068394e-99 6.93183262365262e-96 0.943664243804608 0.726978998384491 27.3 27 3 decreased lymphocyte cell number 2.12686105816029e-11 9.53255294085353e-10 0.943123602831595 0.7265625 27.3 27 3 abnormal liver morphology 2.48577861806075e-15 1.76667837497889e-13 0.94272702295415 0.726256983240223 27.3 27 3 abnormal fertility/fecundity 4.46399211226705e-07 8.28670177557035e-06 0.942429005981667 0.726027397260274 27.3 27 3 abnormal cued conditioning behavior 2.52192912739388e-05 0.000298018940826237 0.941731685222524 0.725490196078431 27.3 27 3 abnormal gastrulation 2.52192912739388e-05 0.000298018940826237 0.941731685222524 0.725490196078431 27.3 27 3 postnatal lethality, incomplete penetrance 2.6813069004609e-45 1.3339501829793e-42 0.941552444323167 0.725352112676056 27.3 27 3 abnormal middle ear morphology 0.00155425698751413 0.010665418638459 0.939976360552958 0.724137931034483 27.3 27 3 lordosis 0.00155425698751413 0.010665418638459 0.939976360552958 0.724137931034483 27.3 27 3 abnormal spinal nerve morphology 0.00155425698751413 0.010665418638459 0.939976360552958 0.724137931034483 27.3 27 3 abnormal embryonic erythropoiesis 0.00155425698751413 0.010665418638459 0.939976360552958 0.724137931034483 27.3 27 3 short sternum 0.00155425698751413 0.010665418638459 0.939976360552958 0.724137931034483 27.3 27 3 neonatal lethality, complete penetrance 3.46558277484253e-36 1.4367728587368e-33 0.939387402933563 0.723684210526316 27.3 27 3 decreased anxiety-related response 8.22225216139415e-11 3.2209216144044e-09 0.93924854300704 0.723577235772358 27.3 27 3 abnormal innervation 5.92118324719961e-05 0.000636239452587863 0.939024003551384 0.723404255319149 27.3 27 3 increased respiratory quotient 5.92118324719961e-05 0.000636239452587863 0.939024003551384 0.723404255319149 27.3 27 3 abnormal digit morphology 7.51094851592044e-07 1.32038759246305e-05 0.937489650604405 0.722222222222222 27.3 27 3 abnormal cochlea morphology 1.81665070080976e-05 0.000225945930913214 0.937489650604405 0.722222222222222 27.3 27 3 neurodegeneration 1.81665070080976e-05 0.000225945930913214 0.937489650604405 0.722222222222222 27.3 27 3 abnormal cell adhesion 1.81665070080976e-05 0.000225945930913214 0.937489650604405 0.722222222222222 27.3 27 3 abnormal long bone epiphyseal plate proliferative zone 1.81665070080976e-05 0.000225945930913214 0.937489650604405 0.722222222222222 27.3 27 3 heart right ventricle hypertrophy 0.000461736466307858 0.00375349496712678 0.937489650604405 0.722222222222222 27.3 27 3 short radius 0.000461736466307858 0.00375349496712678 0.937489650604405 0.722222222222222 27.3 27 3 abnormal megakaryocyte differentiation 0.0132277066421461 0.0581341347567818 0.937489650604405 0.722222222222222 27.3 27 3 abnormal mammary gland morphology 0.0132277066421461 0.0581341347567818 0.937489650604405 0.722222222222222 27.3 27 3 abnormal thyroid cartilage morphology 0.0132277066421461 0.0581341347567818 0.937489650604405 0.722222222222222 27.3 27 3 abnormal thymus cortex morphology 0.0132277066421461 0.0581341347567818 0.937489650604405 0.722222222222222 27.3 27 3 abnormal bile duct morphology 0.0132277066421461 0.0581341347567818 0.937489650604405 0.722222222222222 27.3 27 3 absent allantois 0.0132277066421461 0.0581341347567818 0.937489650604405 0.722222222222222 27.3 27 3 increased circulating glycerol level 0.0132277066421461 0.0581341347567818 0.937489650604405 0.722222222222222 27.3 27 3 decreased activity of thyroid 0.0132277066421461 0.0581341347567818 0.937489650604405 0.722222222222222 27.3 27 3 long tibia 0.0132277066421461 0.0581341347567818 0.937489650604405 0.722222222222222 27.3 27 3 absent inner cell mass 0.0132277066421461 0.0581341347567818 0.937489650604405 0.722222222222222 27.3 27 3 decreased pulmonary respiratory rate 0.0132277066421461 0.0581341347567818 0.937489650604405 0.722222222222222 27.3 27 3 abnormal pregnancy 0.0132277066421461 0.0581341347567818 0.937489650604405 0.722222222222222 27.3 27 3 small thoracic cage 0.0132277066421461 0.0581341347567818 0.937489650604405 0.722222222222222 27.3 27 3 abnormal macrophage chemotaxis 0.0132277066421461 0.0581341347567818 0.937489650604405 0.722222222222222 27.3 27 3 primary atelectasis 0.0132277066421461 0.0581341347567818 0.937489650604405 0.722222222222222 27.3 27 3 decreased fluid intake 0.0132277066421461 0.0581341347567818 0.937489650604405 0.722222222222222 27.3 27 3 increased adipocyte glucose uptake 0.0132277066421461 0.0581341347567818 0.937489650604405 0.722222222222222 27.3 27 3 respiratory failure 8.3470693924115e-13 4.41773087523907e-11 0.93701207054806 0.721854304635762 27.3 27 3 abnormal skeleton morphology 4.34845104038805e-10 1.43268502820732e-08 0.936862567226074 0.721739130434783 27.3 27 3 hunched posture 2.3479400891432e-07 4.71008142882557e-06 0.936576807711898 0.721518987341772 27.3 27 3 abnormal maternal nurturing 5.61125388826878e-06 7.9759965983249e-05 0.93630744423542 0.721311475409836 27.3 27 3 abnormal limb morphology 5.43277580658033e-07 9.95226641879695e-06 0.934605067064084 0.72 27.3 27 3 abnormal hindlimb morphology 4.24980410488633e-05 0.000472504459685871 0.934605067064083 0.72 27.3 27 3 decreased respiratory quotient 4.24980410488633e-05 0.000472504459685871 0.934605067064083 0.72 27.3 27 3 abnormal primitive streak morphology 0.00375162797225248 0.0214532748988001 0.934605067064083 0.72 27.3 27 3 abnormal preimplantation embryo development 0.00375162797225248 0.0214532748988001 0.934605067064083 0.72 27.3 27 3 insulin resistance 3.17263662718349e-11 1.38454975616121e-09 0.934211714763131 0.71969696969697 27.3 27 3 infertility 2.29877879378868e-09 6.86648866541989e-08 0.934119810019917 0.719626168224299 27.3 27 3 increased anxiety-related response 1.00621375334559e-11 4.7675365932327e-10 0.93385798067954 0.719424460431655 27.3 27 3 kidney cortex cysts 0.00109923231196075 0.0079718378309107 0.932982488822653 0.71875 27.3 27 3 abnormal long term potentiation 0.00109923231196075 0.0079718378309107 0.932982488822653 0.71875 27.3 27 3 abnormal diaphragm morphology 0.00109923231196075 0.0079718378309107 0.932982488822653 0.71875 27.3 27 3 abnormal embryonic hematopoiesis 0.00109923231196075 0.0079718378309107 0.932982488822653 0.71875 27.3 27 3 increased fatty acid level 0.00109923231196075 0.0079718378309107 0.932982488822653 0.71875 27.3 27 3 increased hepatocyte apoptosis 0.000328601385362164 0.00281860671064959 0.931942374565325 0.717948717948718 27.3 27 3 failure of heart looping 0.000328601385362164 0.00281860671064959 0.931942374565325 0.717948717948718 27.3 27 3 postnatal lethality, complete penetrance 1.36771614130354e-29 2.83516158457714e-27 0.931511239121874 0.717616580310881 27.3 27 3 pale liver 9.06667416700708e-07 1.56620499933542e-05 0.929693478873807 0.716216216216216 27.3 27 3 anemia 1.28003041974673e-16 1.13716988182857e-14 0.928945268079756 0.71563981042654 27.3 27 3 abnormal vertebrae morphology 2.77247353568929e-09 8.0661145263475e-08 0.928888828121796 0.715596330275229 27.3 27 3 abnormal gait 1.38856135782073e-23 2.22841701779295e-21 0.928387809336401 0.715210355987055 27.3 27 3 abnormal anxiety-related response 0.00913289679810917 0.0429047795756309 0.927187566531829 0.714285714285714 27.3 27 3 abnormal erythrocyte physiology 0.00913289679810917 0.0429047795756309 0.927187566531829 0.714285714285714 27.3 27 3 abnormal clavicle morphology 0.00913289679810917 0.0429047795756309 0.927187566531829 0.714285714285714 27.3 27 3 small spleen 6.41321607417514e-08 1.43075111968705e-06 0.927187566531829 0.714285714285714 27.3 27 3 absent kidney 7.11132557097287e-05 0.000747967118722833 0.927187566531829 0.714285714285714 27.3 27 3 increased sarcoma incidence 7.11132557097287e-05 0.000747967118722833 0.927187566531829 0.714285714285714 27.3 27 3 abnormal craniofacial development 7.11132557097287e-05 0.000747967118722833 0.927187566531829 0.714285714285714 27.3 27 3 short mandible 2.18269220745261e-05 0.00026166008992956 0.927187566531829 0.714285714285714 27.3 27 3 abnormal midbrain development 0.000777265752123699 0.00582364023616778 0.927187566531829 0.714285714285714 27.3 27 3 failure of blastocyst to hatch from the zona pellucida 0.00262936834382909 0.0165165498870577 0.927187566531829 0.714285714285714 27.3 27 3 abnormal retinal inner nuclear layer morphology 0.00262936834382909 0.0165165498870577 0.927187566531829 0.714285714285714 27.3 27 3 abnormal hormone level 0.00262936834382909 0.0165165498870577 0.927187566531829 0.714285714285714 27.3 27 3 abnormal renal tubule epithelium morphology 0.00262936834382909 0.0165165498870577 0.927187566531829 0.714285714285714 27.3 27 3 abnormal mitotic spindle morphology 0.00262936834382909 0.0165165498870577 0.927187566531829 0.714285714285714 27.3 27 3 prolonged QRS complex duration 0.00262936834382909 0.0165165498870577 0.927187566531829 0.714285714285714 27.3 27 3 abnormal pinna reflex 0.0332322554846625 0.11885727608641 0.927187566531829 0.714285714285714 27.3 27 3 abnormal adrenal gland secretion 0.0332322554846625 0.11885727608641 0.927187566531829 0.714285714285714 27.3 27 3 abnormal fluid regulation 0.0332322554846625 0.11885727608641 0.927187566531829 0.714285714285714 27.3 27 3 abnormal prepulse inhibition 0.0332322554846625 0.11885727608641 0.927187566531829 0.714285714285714 27.3 27 3 amyloid beta deposits 0.0332322554846625 0.11885727608641 0.927187566531829 0.714285714285714 27.3 27 3 vascular smooth muscle hypoplasia 0.0332322554846625 0.11885727608641 0.927187566531829 0.714285714285714 27.3 27 3 abnormal sagittal suture morphology 0.0332322554846625 0.11885727608641 0.927187566531829 0.714285714285714 27.3 27 3 abnormal squamosal bone morphology 0.0332322554846625 0.11885727608641 0.927187566531829 0.714285714285714 27.3 27 3 abnormal viscerocranium morphology 0.0332322554846625 0.11885727608641 0.927187566531829 0.714285714285714 27.3 27 3 pulmonary alveolar hemorrhage 0.0332322554846625 0.11885727608641 0.927187566531829 0.714285714285714 27.3 27 3 cochlear degeneration 0.134313441092288 0.307647039334316 0.927187566531829 0.714285714285714 27.3 27 3 polyphalangy 0.134313441092288 0.307647039334316 0.927187566531829 0.714285714285714 27.3 27 3 small L4 dorsal root ganglion 0.134313441092288 0.307647039334316 0.927187566531829 0.714285714285714 27.3 27 3 retina hyperplasia 0.134313441092288 0.307647039334316 0.927187566531829 0.714285714285714 27.3 27 3 abnormal lacrimal gland morphology 0.134313441092288 0.307647039334316 0.927187566531829 0.714285714285714 27.3 27 3 absent amniotic folds 0.134313441092288 0.307647039334316 0.927187566531829 0.714285714285714 27.3 27 3 abnormal tumor incidence 0.134313441092288 0.307647039334316 0.927187566531829 0.714285714285714 27.3 27 3 increased colonic adenoma incidence 0.134313441092288 0.307647039334316 0.927187566531829 0.714285714285714 27.3 27 3 abnormal adrenal gland physiology 0.134313441092288 0.307647039334316 0.927187566531829 0.714285714285714 27.3 27 3 decreased urine calcium level 0.134313441092288 0.307647039334316 0.927187566531829 0.714285714285714 27.3 27 3 abnormal superior semicircular canal morphology 0.134313441092288 0.307647039334316 0.927187566531829 0.714285714285714 27.3 27 3 absent tunnel of Corti 0.134313441092288 0.307647039334316 0.927187566531829 0.714285714285714 27.3 27 3 decreased lateral semicircular canal size 0.134313441092288 0.307647039334316 0.927187566531829 0.714285714285714 27.3 27 3 increased muscle weight 0.134313441092288 0.307647039334316 0.927187566531829 0.714285714285714 27.3 27 3 abnormal locus ceruleus morphology 0.134313441092288 0.307647039334316 0.927187566531829 0.714285714285714 27.3 27 3 utricular macular degeneration 0.134313441092288 0.307647039334316 0.927187566531829 0.714285714285714 27.3 27 3 absent endocochlear potential 0.134313441092288 0.307647039334316 0.927187566531829 0.714285714285714 27.3 27 3 abnormal cochlear nerve compound action potential 0.134313441092288 0.307647039334316 0.927187566531829 0.714285714285714 27.3 27 3 absent thyroid gland 0.134313441092288 0.307647039334316 0.927187566531829 0.714285714285714 27.3 27 3 atherosclerotic lesions 0.134313441092288 0.307647039334316 0.927187566531829 0.714285714285714 27.3 27 3 abnormal thyroid hormone level 0.134313441092288 0.307647039334316 0.927187566531829 0.714285714285714 27.3 27 3 increased chronic myelocytic leukemia incidence 0.134313441092288 0.307647039334316 0.927187566531829 0.714285714285714 27.3 27 3 abnormal body temperature 0.134313441092288 0.307647039334316 0.927187566531829 0.714285714285714 27.3 27 3 uremia 0.134313441092288 0.307647039334316 0.927187566531829 0.714285714285714 27.3 27 3 abnormal spinal cord central canal morphology 0.134313441092288 0.307647039334316 0.927187566531829 0.714285714285714 27.3 27 3 enhanced behavioral response to alcohol 0.134313441092288 0.307647039334316 0.927187566531829 0.714285714285714 27.3 27 3 decreased behavioral withdrawal response 0.134313441092288 0.307647039334316 0.927187566531829 0.714285714285714 27.3 27 3 abnormal cerebellum white matter morphology 0.134313441092288 0.307647039334316 0.927187566531829 0.714285714285714 27.3 27 3 decreased DN4 thymocyte number 0.134313441092288 0.307647039334316 0.927187566531829 0.714285714285714 27.3 27 3 arteritis 0.134313441092288 0.307647039334316 0.927187566531829 0.714285714285714 27.3 27 3 increased oligodendrocyte number 0.134313441092288 0.307647039334316 0.927187566531829 0.714285714285714 27.3 27 3 heart block 0.134313441092288 0.307647039334316 0.927187566531829 0.714285714285714 27.3 27 3 abnormal aortic valve cusp morphology 0.134313441092288 0.307647039334316 0.927187566531829 0.714285714285714 27.3 27 3 thick pulmonary valve 0.134313441092288 0.307647039334316 0.927187566531829 0.714285714285714 27.3 27 3 thick mitral valve cusps 0.134313441092288 0.307647039334316 0.927187566531829 0.714285714285714 27.3 27 3 abnormal impulsive behavior control 0.134313441092288 0.307647039334316 0.927187566531829 0.714285714285714 27.3 27 3 dilated pulmonary alveolar ducts 0.134313441092288 0.307647039334316 0.927187566531829 0.714285714285714 27.3 27 3 abnormal tricarboxylic acid cycle 0.134313441092288 0.307647039334316 0.927187566531829 0.714285714285714 27.3 27 3 impaired branching involved in bronchus morphogenesis 0.134313441092288 0.307647039334316 0.927187566531829 0.714285714285714 27.3 27 3 small tail bud 0.134313441092288 0.307647039334316 0.927187566531829 0.714285714285714 27.3 27 3 absent heart tube 0.134313441092288 0.307647039334316 0.927187566531829 0.714285714285714 27.3 27 3 decreased femur compact bone thickness 0.134313441092288 0.307647039334316 0.927187566531829 0.714285714285714 27.3 27 3 abnormal Mullerian duct topology 0.134313441092288 0.307647039334316 0.927187566531829 0.714285714285714 27.3 27 3 absent connection between subcutaneous lymph vessels and lymph sac 0.134313441092288 0.307647039334316 0.927187566531829 0.714285714285714 27.3 27 3 decreased percent body fat/body weight 1.50557929440146e-06 2.4477964018455e-05 0.924647326623522 0.712328767123288 27.3 27 3 reduced fertility 3.32942199656006e-11 1.4403369072075e-09 0.924519400872744 0.712230215827338 27.3 27 3 abnormal cartilage development 0.000166169183372804 0.00157862312076921 0.923066732902798 0.711111111111111 27.3 27 3 abnormal frontal bone morphology 0.000549645259503756 0.00440462195441066 0.922307631971135 0.710526315789474 27.3 27 3 abnormal reproductive system physiology 0.000549645259503756 0.00440462195441066 0.922307631971135 0.710526315789474 27.3 27 3 thymus hypoplasia 5.48711372271172e-11 2.25073230806208e-09 0.921812566146137 0.710144927536232 27.3 27 3 abnormal nose morphology 0.00184465326727336 0.0120937444258017 0.921205711263882 0.709677419354839 27.3 27 3 inner cell mass degeneration 0.00184465326727336 0.0120937444258017 0.921205711263882 0.709677419354839 27.3 27 3 pale kidney 0.00184465326727336 0.0120937444258017 0.921205711263882 0.709677419354839 27.3 27 3 abnormal mitochondrial ATP synthesis coupled electron transport 0.00184465326727336 0.0120937444258017 0.921205711263882 0.709677419354839 27.3 27 3 increased or absent threshold for auditory brainstem response 2.78057624516985e-21 3.84260189436667e-19 0.920771043580051 0.709342560553633 27.3 27 3 abnormal malleus morphology 0.00632634564988768 0.032682834484103 0.919461003477397 0.708333333333333 27.3 27 3 abnormal foregut morphology 0.00632634564988768 0.032682834484103 0.919461003477397 0.708333333333333 27.3 27 3 abnormal body weight 0.00632634564988768 0.032682834484103 0.919461003477397 0.708333333333333 27.3 27 3 decreased metastatic potential 0.00632634564988768 0.032682834484103 0.919461003477397 0.708333333333333 27.3 27 3 increased stereotypic behavior 0.00632634564988768 0.032682834484103 0.919461003477397 0.708333333333333 27.3 27 3 prolonged QT interval 0.00632634564988768 0.032682834484103 0.919461003477397 0.708333333333333 27.3 27 3 abnormal tumor morphology 0.00632634564988768 0.032682834484103 0.919461003477397 0.708333333333333 27.3 27 3 decreased fatty acid level 0.00632634564988768 0.032682834484103 0.919461003477397 0.708333333333333 27.3 27 3 increased body temperature 0.00632634564988768 0.032682834484103 0.919461003477397 0.708333333333333 27.3 27 3 abnormal lung saccule morphology 0.00632634564988768 0.032682834484103 0.919461003477397 0.708333333333333 27.3 27 3 premature death 4.39970721070483e-60 3.64809056220942e-57 0.918141834175421 0.707317073170732 27.3 27 3 short humerus 0.000388776084689727 0.00326165433614062 0.918141834175421 0.707317073170732 27.3 27 3 decreased erythrocyte cell number 4.73411835600255e-12 2.40328967562374e-10 0.91773852126781 0.707006369426752 27.3 27 3 reduced female fertility 4.3222098743478e-17 4.1351911778616e-15 0.917595971015982 0.706896551724138 27.3 27 3 abnormal enzyme/coenzyme level 2.58338473365995e-05 0.000304557797392376 0.917595971015982 0.706896551724138 27.3 27 3 abnormal neurocranium morphology 1.78210656716716e-06 2.8416603114284e-05 0.917297565822156 0.706666666666667 27.3 27 3 increased bone mineral content 8.97272634165565e-09 2.34943755524931e-07 0.916979996992029 0.706422018348624 27.3 27 3 short maxilla 0.00129550683770485 0.00916806048020147 0.916279477513807 0.705882352941177 27.3 27 3 abnormal endoderm development 0.00129550683770485 0.00916806048020147 0.916279477513807 0.705882352941177 27.3 27 3 abnormal touch/ nociception 0.0224850758342918 0.0855877982215774 0.916279477513807 0.705882352941177 27.3 27 3 abnormal testis development 0.0224850758342918 0.0855877982215774 0.916279477513807 0.705882352941177 27.3 27 3 abnormal tarsal bone morphology 0.0224850758342918 0.0855877982215774 0.916279477513807 0.705882352941177 27.3 27 3 abnormal electroretinogram waveform feature 0.0224850758342918 0.0855877982215774 0.916279477513807 0.705882352941177 27.3 27 3 delayed heart development 0.0224850758342918 0.0855877982215774 0.916279477513807 0.705882352941177 27.3 27 3 abnormal gluconeogenesis 8.3967040508681e-05 0.000864877901719851 0.916279477513807 0.705882352941177 27.3 27 3 failure of chorioallantoic fusion 8.3967040508681e-05 0.000864877901719851 0.916279477513807 0.705882352941177 27.3 27 3 impaired glucose tolerance 5.18251305565385e-18 5.48574520252721e-16 0.915971587904428 0.705645161290323 27.3 27 3 increased rib number 1.27644654922298e-06 2.08892157315274e-05 0.915300546448088 0.705128205128205 27.3 27 3 abnormal cornea morphology 1.27644654922298e-06 2.08892157315274e-05 0.915300546448088 0.705128205128205 27.3 27 3 increased double-negative T cell number 1.84241305564876e-05 0.000228578677103555 0.915027729593706 0.704918032786885 27.3 27 3 small kidney 2.86795581412791e-07 5.68449409373958e-06 0.914544099715486 0.704545454545455 27.3 27 3 renal interstitial fibrosis 0.000275082175284789 0.00240939053176378 0.914544099715486 0.704545454545455 27.3 27 3 abnormal amino acid level 0.000275082175284789 0.00240939053176378 0.914544099715486 0.704545454545455 27.3 27 3 decreased blood urea nitrogen level 0.000275082175284789 0.00240939053176378 0.914544099715486 0.704545454545455 27.3 27 3 cardiac hypertrophy 6.47566573889257e-08 1.43823379691922e-06 0.913942029867089 0.704081632653061 27.3 27 3 diluted coat color 5.96884069316765e-05 0.000638601773086216 0.913451454435061 0.703703703703704 27.3 27 3 decreased platelet aggregation 5.96884069316765e-05 0.000638601773086216 0.913451454435061 0.703703703703704 27.3 27 3 increased blood urea nitrogen level 5.51938375042359e-11 2.25073230806208e-09 0.913119893108587 0.703448275862069 27.3 27 3 decreased caudal vertebrae number 1.31381778556682e-05 0.000171554947065484 0.912700260804769 0.703125 27.3 27 3 abnormal pulmonary alveolus morphology 4.64762545776941e-08 1.07543891406525e-06 0.912499446665978 0.702970297029703 27.3 27 3 impaired skeletal muscle contractility 0.00091080501044912 0.00675298796868014 0.912152092479961 0.702702702702703 27.3 27 3 abnormal respiratory electron transport chain 0.00091080501044912 0.00675298796868014 0.912152092479961 0.702702702702703 27.3 27 3 neuron degeneration 0.000194712853553527 0.00179721047574916 0.911405650505755 0.702127659574468 27.3 27 3 incomplete embryo turning 4.24335751277902e-05 0.000472504459685871 0.910921117996183 0.701754385964912 27.3 27 3 abnormal heart morphology 2.20558533868302e-16 1.85979441694035e-14 0.910329610776705 0.701298701298701 27.3 27 3 abnormal retinal pigmentation 4.68352740947357e-07 8.66191407514163e-06 0.910135841170324 0.701149425287356 27.3 27 3 decreased startle reflex 5.43503452577384e-09 1.47755720031283e-07 0.909753270409008 0.700854700854701 27.3 27 3 decreased double-positive T cell number 7.56885015417696e-08 1.62992742649702e-06 0.908643815201192 0.7 27.3 27 3 abnormal retinal pigment epithelium morphology 1.49155113700561e-06 2.432939969378e-05 0.908643815201192 0.7 27.3 27 3 abnormal long bone epiphyseal plate morphology 3.01706754271493e-05 0.000351520164520065 0.908643815201192 0.7 27.3 27 3 increased erythrocyte cell number 3.01706754271493e-05 0.000351520164520065 0.908643815201192 0.7 27.3 27 3 decreased oocyte number 0.000137882089918414 0.00133455913880177 0.908643815201192 0.7 27.3 27 3 abnormal pancreatic beta cell morphology 0.000640996687938469 0.00502160526835204 0.908643815201192 0.7 27.3 27 3 increased metastatic potential 0.00306096711135758 0.0183694950289553 0.908643815201192 0.7 27.3 27 3 abnormal response to new environment 0.00306096711135758 0.0183694950289553 0.908643815201192 0.7 27.3 27 3 abnormal lactation 0.00306096711135758 0.0183694950289553 0.908643815201192 0.7 27.3 27 3 enhanced paired-pulse facilitation 0.00306096711135758 0.0183694950289553 0.908643815201192 0.7 27.3 27 3 small gonad 0.0153328616295744 0.0627260465087192 0.908643815201192 0.7 27.3 27 3 abnormal circulating enzyme level 0.0153328616295744 0.0627260465087192 0.908643815201192 0.7 27.3 27 3 abnormal hearing physiology 0.0153328616295744 0.0627260465087192 0.908643815201192 0.7 27.3 27 3 abnormal trachea morphology 0.0153328616295744 0.0627260465087192 0.908643815201192 0.7 27.3 27 3 abnormal lens epithelium morphology 0.0153328616295744 0.0627260465087192 0.908643815201192 0.7 27.3 27 3 abnormal heart right ventricle morphology 0.0153328616295744 0.0627260465087192 0.908643815201192 0.7 27.3 27 3 kidney atrophy 0.0153328616295744 0.0627260465087192 0.908643815201192 0.7 27.3 27 3 abnormal incus morphology 0.0153328616295744 0.0627260465087192 0.908643815201192 0.7 27.3 27 3 abnormal lateral semicircular canal morphology 0.0857222807360099 0.218365768899974 0.908643815201192 0.7 27.3 27 3 absent palatine bone horizontal plate 0.0857222807360099 0.218365768899974 0.908643815201192 0.7 27.3 27 3 small petrosal ganglion 0.0857222807360099 0.218365768899974 0.908643815201192 0.7 27.3 27 3 abnormal grooming behavior 0.0857222807360099 0.218365768899974 0.908643815201192 0.7 27.3 27 3 abnormal pituitary secretion 0.0857222807360099 0.218365768899974 0.908643815201192 0.7 27.3 27 3 rhinitis 0.0857222807360099 0.218365768899974 0.908643815201192 0.7 27.3 27 3 abnormal mammary gland physiology 0.0857222807360099 0.218365768899974 0.908643815201192 0.7 27.3 27 3 alcohol preference 0.0857222807360099 0.218365768899974 0.908643815201192 0.7 27.3 27 3 abnormal airway responsiveness 0.0857222807360099 0.218365768899974 0.908643815201192 0.7 27.3 27 3 abnormal PNS synaptic transmission 0.0857222807360099 0.218365768899974 0.908643815201192 0.7 27.3 27 3 abnormal neuron specification 0.0857222807360099 0.218365768899974 0.908643815201192 0.7 27.3 27 3 aneurysm 0.0857222807360099 0.218365768899974 0.908643815201192 0.7 27.3 27 3 peritoneal inflammation 0.0857222807360099 0.218365768899974 0.908643815201192 0.7 27.3 27 3 absent seminal vesicle 0.0857222807360099 0.218365768899974 0.908643815201192 0.7 27.3 27 3 increased defecation amount 0.0857222807360099 0.218365768899974 0.908643815201192 0.7 27.3 27 3 absent pharyngeal arches 0.0857222807360099 0.218365768899974 0.908643815201192 0.7 27.3 27 3 abnormal reproductive system development 0.0857222807360099 0.218365768899974 0.908643815201192 0.7 27.3 27 3 abnormal utricular macula morphology 0.0857222807360099 0.218365768899974 0.908643815201192 0.7 27.3 27 3 ascites 0.0857222807360099 0.218365768899974 0.908643815201192 0.7 27.3 27 3 abnormal gonadal fat pad morphology 0.0857222807360099 0.218365768899974 0.908643815201192 0.7 27.3 27 3 vascular smooth muscle hyperplasia 0.0857222807360099 0.218365768899974 0.908643815201192 0.7 27.3 27 3 ventricular premature beat 0.0857222807360099 0.218365768899974 0.908643815201192 0.7 27.3 27 3 protruding tongue 0.0857222807360099 0.218365768899974 0.908643815201192 0.7 27.3 27 3 abnormal cerebellar granule cell migration 0.0857222807360099 0.218365768899974 0.908643815201192 0.7 27.3 27 3 increased kidney iron level 0.0857222807360099 0.218365768899974 0.908643815201192 0.7 27.3 27 3 abnormal left subclavian artery morphology 0.0857222807360099 0.218365768899974 0.908643815201192 0.7 27.3 27 3 sinus bradycardia 0.0857222807360099 0.218365768899974 0.908643815201192 0.7 27.3 27 3 decreased trabecular bone connectivity density 0.0857222807360099 0.218365768899974 0.908643815201192 0.7 27.3 27 3 decreased macrophage cytokine production 0.0857222807360099 0.218365768899974 0.908643815201192 0.7 27.3 27 3 lethality during fetal growth through weaning, complete penetrance 0.0857222807360099 0.218365768899974 0.908643815201192 0.7 27.3 27 3 increased circulating bilirubin level 9.76802012416811e-05 0.000981735355913866 0.906194640497146 0.69811320754717 27.3 27 3 increased susceptibility to pharmacologically induced seizures 1.71597044562013e-07 3.5276665152728e-06 0.905939518132141 0.697916666666667 27.3 27 3 increased circulating creatinine level 7.61333699076012e-07 1.33367434961379e-05 0.905625064984577 0.697674418604651 27.3 27 3 decreased oxygen consumption 0.000451551976869033 0.00370704799492316 0.905625064984577 0.697674418604651 27.3 27 3 abnormal tooth development 0.00213664573165226 0.0138589472163885 0.904710292191663 0.696969696969697 27.3 27 3 abnormal aorta morphology 0.00213664573165226 0.0138589472163885 0.904710292191663 0.696969696969697 27.3 27 3 enlarged pericardium 0.00213664573165226 0.0138589472163885 0.904710292191663 0.696969696969697 27.3 27 3 dextrocardia 0.00213664573165226 0.0138589472163885 0.904710292191663 0.696969696969697 27.3 27 3 increased cardiomyocyte apoptosis 0.00213664573165226 0.0138589472163885 0.904710292191663 0.696969696969697 27.3 27 3 cardiovascular system phenotype 0.00213664573165226 0.0138589472163885 0.904710292191663 0.696969696969697 27.3 27 3 abnormal rib morphology 7.4116653906476e-10 2.37890550441754e-08 0.903836175967323 0.696296296296296 27.3 27 3 abnormal myocardium layer morphology 2.42187772537983e-06 3.73029154296119e-05 0.903714463581656 0.69620253164557 27.3 27 3 abnormal forelimb morphology 0.000318387113935551 0.0027499581455371 0.903000064796216 0.695652173913043 27.3 27 3 abnormal allantois morphology 0.000318387113935551 0.0027499581455371 0.903000064796216 0.695652173913043 27.3 27 3 abnormal pulmonary artery morphology 0.0105190357512178 0.0488173534163328 0.903000064796216 0.695652173913043 27.3 27 3 abnormal postnatal growth 0.0105190357512178 0.0488173534163328 0.903000064796216 0.695652173913043 27.3 27 3 abnormal cardiovascular development 0.0105190357512178 0.0488173534163328 0.903000064796216 0.695652173913043 27.3 27 3 abnormal sacral vertebrae morphology 0.0105190357512178 0.0488173534163328 0.903000064796216 0.695652173913043 27.3 27 3 abnormal palatal shelf fusion at midline 0.0105190357512178 0.0488173534163328 0.903000064796216 0.695652173913043 27.3 27 3 syndactyly 4.90857964685225e-05 0.000535530345243201 0.902043496930966 0.694915254237288 27.3 27 3 increased hemoglobin content 4.90857964685225e-05 0.000535530345243201 0.902043496930966 0.694915254237288 27.3 27 3 abnormal trophoblast giant cell morphology 0.00149437776534152 0.0103838215397553 0.901432356350389 0.694444444444444 27.3 27 3 cataract 7.31220734170509e-09 1.95581889919262e-07 0.901134362183001 0.694214876033058 27.3 27 3 eyelids open at birth 0.000158684281315359 0.00151818134527675 0.89865871833085 0.692307692307692 27.3 27 3 abnormal xiphoid process morphology 0.00725138203549281 0.0353682604182125 0.89865871833085 0.692307692307692 27.3 27 3 no spontaneous movement 0.00725138203549281 0.0353682604182125 0.89865871833085 0.692307692307692 27.3 27 3 increased susceptibility to otitis media 0.00725138203549281 0.0353682604182125 0.89865871833085 0.692307692307692 27.3 27 3 increased leukemia incidence 0.00725138203549281 0.0353682604182125 0.89865871833085 0.692307692307692 27.3 27 3 abnormal membranous labyrinth morphology 0.0562253500451735 0.174498513084678 0.89865871833085 0.692307692307692 27.3 27 3 abnormal grip strength 0.0562253500451735 0.174498513084678 0.89865871833085 0.692307692307692 27.3 27 3 abnormal pulmonary alveolus epithelial cell morphology 0.0562253500451735 0.174498513084678 0.89865871833085 0.692307692307692 27.3 27 3 abnormal tail bud morphology 0.0562253500451735 0.174498513084678 0.89865871833085 0.692307692307692 27.3 27 3 increased synaptic depression 0.0562253500451735 0.174498513084678 0.89865871833085 0.692307692307692 27.3 27 3 abnormal soleus morphology 0.0562253500451735 0.174498513084678 0.89865871833085 0.692307692307692 27.3 27 3 anal atresia 0.0562253500451735 0.174498513084678 0.89865871833085 0.692307692307692 27.3 27 3 abnormal retinal inner plexiform layer morphology 0.0562253500451735 0.174498513084678 0.89865871833085 0.692307692307692 27.3 27 3 decreased endocochlear potential 0.0562253500451735 0.174498513084678 0.89865871833085 0.692307692307692 27.3 27 3 decreased luteinizing hormone level 0.0562253500451735 0.174498513084678 0.89865871833085 0.692307692307692 27.3 27 3 hyperalgesia 0.0562253500451735 0.174498513084678 0.89865871833085 0.692307692307692 27.3 27 3 increased circulating thyroxine level 0.0562253500451735 0.174498513084678 0.89865871833085 0.692307692307692 27.3 27 3 increased renin activity 0.0562253500451735 0.174498513084678 0.89865871833085 0.692307692307692 27.3 27 3 orthokeratosis 0.0562253500451735 0.174498513084678 0.89865871833085 0.692307692307692 27.3 27 3 abnormal circulating hormone level 0.00104699397632234 0.0076599926944171 0.89865871833085 0.692307692307692 27.3 27 3 decreased trabecular bone volume 0.00104699397632234 0.0076599926944171 0.89865871833085 0.692307692307692 27.3 27 3 decreased mean corpuscular hemoglobin 1.75382046262652e-05 0.000220334767716336 0.89719032173227 0.691176470588235 27.3 27 3 abnormal myocardial fiber morphology 3.18916202328666e-07 6.1976879163481e-06 0.896599935470985 0.690721649484536 27.3 27 3 disheveled coat 0.000734683501612998 0.00566674483802273 0.896281314314101 0.69047619047619 27.3 27 3 abnormal muscle morphology 0.000734683501612998 0.00566674483802273 0.896281314314101 0.69047619047619 27.3 27 3 aphagia 0.00501850469119567 0.0276490153252475 0.895215581479007 0.689655172413793 27.3 27 3 polychromatophilia 0.00501850469119567 0.0276490153252475 0.895215581479007 0.689655172413793 27.3 27 3 thin ventricular wall 1.00605662744387e-06 1.71408620600455e-05 0.894220897499586 0.688888888888889 27.3 27 3 oxidative stress 1.00605662744387e-06 1.71408620600455e-05 0.894220897499586 0.688888888888889 27.3 27 3 albuminuria 0.00051624665737561 0.00418294319290499 0.894220897499586 0.688888888888889 27.3 27 3 abnormal metabolism 0.00051624665737561 0.00418294319290499 0.894220897499586 0.688888888888889 27.3 27 3 decreased circulating glucose level 9.83204324849434e-18 9.98253370637946e-16 0.893290386680128 0.688172043010753 27.3 27 3 oligodactyly 0.000363206575361007 0.00308353705191298 0.892418032786885 0.6875 27.3 27 3 abnormal cardiovascular system morphology 0.000363206575361007 0.00308353705191298 0.892418032786885 0.6875 27.3 27 3 abnormal lymphatic vessel morphology 0.00348457936896105 0.0201111164275884 0.892418032786885 0.6875 27.3 27 3 abnormal spongiotrophoblast layer morphology 0.00348457936896105 0.0201111164275884 0.892418032786885 0.6875 27.3 27 3 abnormal serotonin level 0.00348457936896105 0.0201111164275884 0.892418032786885 0.6875 27.3 27 3 abnormal bone marrow cell number 0.0375056942026457 0.124643172116341 0.892418032786885 0.6875 27.3 27 3 decreased mast cell number 0.0375056942026457 0.124643172116341 0.892418032786885 0.6875 27.3 27 3 poor circulation 0.0375056942026457 0.124643172116341 0.892418032786885 0.6875 27.3 27 3 abnormal meiosis 0.0375056942026457 0.124643172116341 0.892418032786885 0.6875 27.3 27 3 white spotting 0.0375056942026457 0.124643172116341 0.892418032786885 0.6875 27.3 27 3 paternal imprinting 0.0375056942026457 0.124643172116341 0.892418032786885 0.6875 27.3 27 3 small epididymis 0.0375056942026457 0.124643172116341 0.892418032786885 0.6875 27.3 27 3 loose skin 0.0375056942026457 0.124643172116341 0.892418032786885 0.6875 27.3 27 3 decreased liver cholesterol level 0.0375056942026457 0.124643172116341 0.892418032786885 0.6875 27.3 27 3 abnormal thoracic cage shape 0.0375056942026457 0.124643172116341 0.892418032786885 0.6875 27.3 27 3 abnormal pulmonary alveolus wall morphology 0.0375056942026457 0.124643172116341 0.892418032786885 0.6875 27.3 27 3 embryonic lethality between somite formation and embryo turning, incomplete penetrance 0.0375056942026457 0.124643172116341 0.892418032786885 0.6875 27.3 27 3 decreased midbrain size 0.0375056942026457 0.124643172116341 0.892418032786885 0.6875 27.3 27 3 decreased white adipose tissue amount 2.81648792477025e-05 0.00033047234494651 0.891207153502236 0.686567164179104 27.3 27 3 decreased leukocyte cell number 2.50703872402405e-09 7.38018795977493e-08 0.890641487267071 0.686131386861314 27.3 27 3 increased circulating HDL cholesterol level 1.84925142515009e-07 3.77050239349249e-06 0.890100063870556 0.685714285714286 27.3 27 3 abnormal action potential 1.99655103376002e-05 0.000245661587480095 0.890100063870556 0.685714285714286 27.3 27 3 decreased bone volume 0.002426214660791 0.0155146760121275 0.890100063870556 0.685714285714286 27.3 27 3 enlarged heart 1.07450930508305e-14 7.22389701728128e-13 0.889620484094763 0.685344827586207 27.3 27 3 seminiferous tubule degeneration 1.41599111835899e-05 0.000182975475684051 0.889083967907233 0.684931506849315 27.3 27 3 abnormal circulating amino acid level 0.000127286900779151 0.00124655970743362 0.888148090046278 0.684210526315789 27.3 27 3 increased macrophage cell number 0.000127286900779151 0.00124655970743362 0.888148090046278 0.684210526315789 27.3 27 3 decreased hair follicle number 0.00169331780416408 0.011384129832049 0.888148090046278 0.684210526315789 27.3 27 3 kyphoscoliosis 0.0253093024290997 0.0953892269581598 0.888148090046278 0.684210526315789 27.3 27 3 delayed sexual maturation 0.0253093024290997 0.0953892269581598 0.888148090046278 0.684210526315789 27.3 27 3 abnormal digestive system development 0.0253093024290997 0.0953892269581598 0.888148090046278 0.684210526315789 27.3 27 3 absent amnion 0.0253093024290997 0.0953892269581598 0.888148090046278 0.684210526315789 27.3 27 3 Leydig cell hypoplasia 0.0253093024290997 0.0953892269581598 0.888148090046278 0.684210526315789 27.3 27 3 decreased fertilization frequency 0.0253093024290997 0.0953892269581598 0.888148090046278 0.684210526315789 27.3 27 3 abnormal placenta labyrinth morphology 7.13164026574938e-06 9.938350230281e-05 0.887283291516535 0.683544303797468 27.3 27 3 decreased B cell proliferation 7.13164026574938e-06 9.938350230281e-05 0.887283291516535 0.683544303797468 27.3 27 3 increased heart weight 2.84492119406308e-09 8.22876915143245e-08 0.887165081645563 0.683453237410072 27.3 27 3 abnormal mammary gland development 0.00118424106416653 0.00851387181246894 0.886481770927992 0.682926829268293 27.3 27 3 Leydig cell hyperplasia 0.00118424106416653 0.00851387181246894 0.886481770927992 0.682926829268293 27.3 27 3 hemopericardium 0.00118424106416653 0.00851387181246894 0.886481770927992 0.682926829268293 27.3 27 3 reduced male fertility 3.77226250026028e-14 2.23416737366606e-12 0.886342299283731 0.682819383259912 27.3 27 3 cardiac fibrosis 3.59746758988857e-06 5.34250783871512e-05 0.885736828263347 0.682352941176471 27.3 27 3 abnormal tail morphology 4.49494251351044e-05 0.000496940866771432 0.885042677144018 0.681818181818182 27.3 27 3 muscular atrophy 0.00082970155169241 0.00620716574386427 0.885042677144018 0.681818181818182 27.3 27 3 abnormal facial nerve morphology 0.0172239578842475 0.068771420926269 0.885042677144018 0.681818181818182 27.3 27 3 intestinal inflammation 0.0172239578842475 0.068771420926269 0.885042677144018 0.681818181818182 27.3 27 3 testis hypoplasia 0.0172239578842475 0.068771420926269 0.885042677144018 0.681818181818182 27.3 27 3 increased skin papilloma incidence 0.0172239578842475 0.068771420926269 0.885042677144018 0.681818181818182 27.3 27 3 increased myocardial infarction size 0.0172239578842475 0.068771420926269 0.885042677144018 0.681818181818182 27.3 27 3 abnormal retinal outer plexiform layer morphology 0.0172239578842475 0.068771420926269 0.885042677144018 0.681818181818182 27.3 27 3 abnormal basement membrane morphology 0.0172239578842475 0.068771420926269 0.885042677144018 0.681818181818182 27.3 27 3 abnormal mesenteric lymph node morphology 0.0172239578842475 0.068771420926269 0.885042677144018 0.681818181818182 27.3 27 3 increased thermal nociceptive threshold 1.81718827444589e-06 2.87914384247398e-05 0.88439429423036 0.681318681318681 27.3 27 3 cochlear outer hair cell degeneration 2.25323234490007e-05 0.000268177773107126 0.883403709223381 0.680555555555556 27.3 27 3 increased circulating chloride level 0.000409138979133195 0.00338117345712234 0.882682563338301 0.68 27.3 27 3 testicular atrophy 0.000409138979133195 0.00338117345712234 0.882682563338301 0.68 27.3 27 3 mandible hypoplasia 0.0117976207148624 0.0529721688235023 0.882682563338301 0.68 27.3 27 3 spontaneous skin ulceration 0.0117976207148624 0.0529721688235023 0.882682563338301 0.68 27.3 27 3 abnormal jaw morphology 0.00812229146872487 0.0387424736883089 0.880828188205237 0.678571428571429 27.3 27 3 abnormal respiration 0.00812229146872487 0.0387424736883089 0.880828188205237 0.678571428571429 27.3 27 3 abnormal seminiferous tubule morphology 2.58064633296152e-09 7.55218559204916e-08 0.880193128228161 0.678082191780822 27.3 27 3 no abnormal phenotype detected 3.84074297669723e-97 9.55384815453437e-94 0.879839544402307 0.677809798270893 27.3 27 3 abnormal retinal photoreceptor layer morphology 0.00561522618393446 0.0304642860033522 0.879332724388251 0.67741935483871 27.3 27 3 decreased neuronal precursor cell number 0.00561522618393446 0.0304642860033522 0.879332724388251 0.67741935483871 27.3 27 3 small cranium 0.00561522618393446 0.0304642860033522 0.879332724388251 0.67741935483871 27.3 27 3 abnormal inhibitory postsynaptic currents 5.03842898197988e-05 0.000547296597933403 0.878101165950732 0.676470588235294 27.3 27 3 abnormal oocyte morphology 0.00389539069172411 0.0222242760221645 0.878101165950732 0.676470588235294 27.3 27 3 increased susceptibility to weight gain 0.00389539069172411 0.0222242760221645 0.878101165950732 0.676470588235294 27.3 27 3 abnormal retina morphology 1.39843412173183e-12 7.32337869012193e-11 0.877737562983465 0.676190476190476 27.3 27 3 corneal opacity 3.56412692946293e-05 0.000411404442554016 0.877563443252661 0.676056338028169 27.3 27 3 abnormal skeletal muscle fiber morphology 3.56412692946293e-05 0.000411404442554016 0.877563443252661 0.676056338028169 27.3 27 3 thrombocytopenia 4.05290264482177e-09 1.13916331401064e-07 0.877311269849427 0.675862068965517 27.3 27 3 abnormal glucose homeostasis 4.5236163152676e-11 1.8911757284417e-09 0.877262082180115 0.675824175824176 27.3 27 3 increased brown adipose tissue amount 0.00271015433803402 0.0169172118340267 0.877069319692271 0.675675675675676 27.3 27 3 increased circulating phosphate level 0.00271015433803402 0.0169172118340267 0.877069319692271 0.675675675675676 27.3 27 3 abnormal pancreatic beta cell physiology 0.00271015433803402 0.0169172118340267 0.877069319692271 0.675675675675676 27.3 27 3 abnormal calcium ion homeostasis 0.00271015433803402 0.0169172118340267 0.877069319692271 0.675675675675676 27.3 27 3 abnormal humerus morphology 0.00271015433803402 0.0169172118340267 0.877069319692271 0.675675675675676 27.3 27 3 head bobbing 0.00189021911373499 0.0123734738037258 0.876192250372578 0.675 27.3 27 3 abnormal kidney morphology 1.38862457911935e-10 5.19429118881112e-09 0.875265062806047 0.674285714285714 27.3 27 3 increased T cell derived lymphoma incidence 0.000648908779704603 0.005044251842235 0.874205419872867 0.673469387755102 27.3 27 3 decreased body temperature 0.00045580915882806 0.0037235641464197 0.873695976154993 0.673076923076923 27.3 27 3 abnormal platelet physiology 0.000320586310831244 0.00276415406652589 0.873242108115431 0.672727272727273 27.3 27 3 abnormal osteoclast physiology 0.000112270297825803 0.00111708946336674 0.872135804769001 0.671875 27.3 27 3 abnormal tooth morphology 0.000112270297825803 0.00111708946336674 0.872135804769001 0.671875 27.3 27 3 abnormal femur morphology 7.92814508138812e-05 0.000825157359412257 0.871833084947839 0.671641791044776 27.3 27 3 decreased bone marrow cell number 3.96259984908814e-05 0.000451119776869874 0.871302288549089 0.671232876712329 27.3 27 3 circling 9.97414719821467e-06 0.000133390812664296 0.870465503638117 0.670588235294118 27.3 27 3 increased T cell number 7.07401392277597e-06 9.9135828917776e-05 0.870291965858285 0.670454545454545 27.3 27 3 increased monocyte cell number 1.7973801635695e-06 2.85685824720711e-05 0.869701937406855 0.67 27.3 27 3 abnormal renal glomerulus morphology 6.45591370417683e-07 1.15118891319999e-05 0.869344672472963 0.669724770642202 27.3 27 3 increased circulating triglyceride level 1.097651882836e-08 2.82943943891663e-07 0.868359114034637 0.668965517241379 27.3 27 3 decreased bone mineral content 9.17255235807419e-12 4.4190708789331e-10 0.867455290611028 0.668269230769231 27.3 27 3 increased incidence of induced tumors 0.0277327912925049 0.103893551717027 0.865375062096374 0.666666666666667 27.3 27 3 liver degeneration 0.0277327912925049 0.103893551717027 0.865375062096374 0.666666666666667 27.3 27 3 increased acute inflammation 0.0277327912925049 0.103893551717027 0.865375062096374 0.666666666666667 27.3 27 3 abnormal stapes morphology 0.0277327912925049 0.103893551717027 0.865375062096374 0.666666666666667 27.3 27 3 enlarged spleen 1.60397518215794e-15 1.1910114225725e-13 0.865375062096374 0.666666666666667 27.3 27 3 decreased hemoglobin content 2.38710649515667e-08 5.8501747849283e-07 0.865375062096374 0.666666666666667 27.3 27 3 deafness 2.79466869411119e-06 4.21317477369793e-05 0.865375062096374 0.666666666666667 27.3 27 3 abnormal skeleton development 2.1928624077709e-05 0.000262247367275486 0.865375062096374 0.666666666666667 27.3 27 3 decreased spleen weight 8.75224083573835e-05 0.000893204882599138 0.865375062096374 0.666666666666667 27.3 27 3 abnormal eating behavior 0.000249124910249193 0.00222512823786308 0.865375062096374 0.666666666666667 27.3 27 3 thymus atrophy 0.00102026345752962 0.00749750472852267 0.865375062096374 0.666666666666667 27.3 27 3 decreased B-1 B cell number 0.00298596545984755 0.0180529063876496 0.865375062096374 0.666666666666667 27.3 27 3 abnormal uterus morphology 0.00428988845168997 0.0242800853778813 0.865375062096374 0.666666666666667 27.3 27 3 abnormal limb bone morphology 0.00428988845168997 0.0242800853778813 0.865375062096374 0.666666666666667 27.3 27 3 renal hypoplasia 0.00428988845168997 0.0242800853778813 0.865375062096374 0.666666666666667 27.3 27 3 narrow eye opening 0.00428988845168997 0.0242800853778813 0.865375062096374 0.666666666666667 27.3 27 3 abnormal ovarian folliculogenesis 0.00618044664357865 0.0322980273653401 0.865375062096374 0.666666666666667 27.3 27 3 abnormal skeleton physiology 0.00618044664357865 0.0322980273653401 0.865375062096374 0.666666666666667 27.3 27 3 single kidney 0.00618044664357865 0.0322980273653401 0.865375062096374 0.666666666666667 27.3 27 3 head tossing 0.00618044664357865 0.0322980273653401 0.865375062096374 0.666666666666667 27.3 27 3 myeloid hyperplasia 0.00618044664357865 0.0322980273653401 0.865375062096374 0.666666666666667 27.3 27 3 emphysema 0.00893357985087193 0.042087651286068 0.865375062096374 0.666666666666667 27.3 27 3 abnormal brain vasculature morphology 0.00893357985087193 0.042087651286068 0.865375062096374 0.666666666666667 27.3 27 3 abnormal heart valve morphology 0.0129642445528158 0.0578449476683935 0.865375062096374 0.666666666666667 27.3 27 3 decreased susceptibility to pharmacologically induced seizures 0.0129642445528158 0.0578449476683935 0.865375062096374 0.666666666666667 27.3 27 3 abnormal digestive system morphology 0.0189044159538783 0.0746424360083686 0.865375062096374 0.666666666666667 27.3 27 3 curly vibrissae 0.0189044159538783 0.0746424360083686 0.865375062096374 0.666666666666667 27.3 27 3 abnormal startle reflex 0.0189044159538783 0.0746424360083686 0.865375062096374 0.666666666666667 27.3 27 3 hemolytic anemia 0.0189044159538783 0.0746424360083686 0.865375062096374 0.666666666666667 27.3 27 3 apnea 0.0189044159538783 0.0746424360083686 0.865375062096374 0.666666666666667 27.3 27 3 blindness 0.0189044159538783 0.0746424360083686 0.865375062096374 0.666666666666667 27.3 27 3 abnormal primitive streak formation 0.0189044159538783 0.0746424360083686 0.865375062096374 0.666666666666667 27.3 27 3 abnormal osteoblast morphology 0.0189044159538783 0.0746424360083686 0.865375062096374 0.666666666666667 27.3 27 3 abnormal retinal ganglion layer morphology 0.0189044159538783 0.0746424360083686 0.865375062096374 0.666666666666667 27.3 27 3 blepharoptosis 0.0409998142185831 0.132738502515908 0.865375062096374 0.666666666666667 27.3 27 3 absent ureter 0.0409998142185831 0.132738502515908 0.865375062096374 0.666666666666667 27.3 27 3 jerky movement 0.0409998142185831 0.132738502515908 0.865375062096374 0.666666666666667 27.3 27 3 atrioventricular block 0.0409998142185831 0.132738502515908 0.865375062096374 0.666666666666667 27.3 27 3 interdigital webbing 0.0612419265947603 0.182442266352654 0.865375062096374 0.666666666666667 27.3 27 3 abnormal prostate gland morphology 0.0612419265947603 0.182442266352654 0.865375062096374 0.666666666666667 27.3 27 3 hyperpigmentation 0.0612419265947603 0.182442266352654 0.865375062096374 0.666666666666667 27.3 27 3 audiogenic seizures 0.0612419265947603 0.182442266352654 0.865375062096374 0.666666666666667 27.3 27 3 absent egg cylinders 0.0612419265947603 0.182442266352654 0.865375062096374 0.666666666666667 27.3 27 3 placental labyrinth hypoplasia 0.0612419265947603 0.182442266352654 0.865375062096374 0.666666666666667 27.3 27 3 abnormal cricoid cartilage morphology 0.0612419265947603 0.182442266352654 0.865375062096374 0.666666666666667 27.3 27 3 abnormal lymph node B cell domain morphology 0.0612419265947603 0.182442266352654 0.865375062096374 0.666666666666667 27.3 27 3 dilated ureter 0.0612419265947603 0.182442266352654 0.865375062096374 0.666666666666667 27.3 27 3 liver vascular congestion 0.0612419265947603 0.182442266352654 0.865375062096374 0.666666666666667 27.3 27 3 bicuspid aortic valve 0.0612419265947603 0.182442266352654 0.865375062096374 0.666666666666667 27.3 27 3 herniated liver 0.0612419265947603 0.182442266352654 0.865375062096374 0.666666666666667 27.3 27 3 abnormal supraoccipital bone morphology 0.0928124005804828 0.233793262221723 0.865375062096374 0.666666666666667 27.3 27 3 mesocardia 0.0928124005804828 0.233793262221723 0.865375062096374 0.666666666666667 27.3 27 3 interstitial pneumonia 0.0928124005804828 0.233793262221723 0.865375062096374 0.666666666666667 27.3 27 3 increased papilloma incidence 0.0928124005804828 0.233793262221723 0.865375062096374 0.666666666666667 27.3 27 3 abnormal tracheal ciliated epithelium morphology 0.0928124005804828 0.233793262221723 0.865375062096374 0.666666666666667 27.3 27 3 abnormal gastrocnemius morphology 0.0928124005804828 0.233793262221723 0.865375062096374 0.666666666666667 27.3 27 3 abnormal aorta elastic fiber morphology 0.0928124005804828 0.233793262221723 0.865375062096374 0.666666666666667 27.3 27 3 abnormal alisphenoid bone morphology 0.0928124005804828 0.233793262221723 0.865375062096374 0.666666666666667 27.3 27 3 dilated bile duct 0.0928124005804828 0.233793262221723 0.865375062096374 0.666666666666667 27.3 27 3 increased fear-related response 0.0928124005804828 0.233793262221723 0.865375062096374 0.666666666666667 27.3 27 3 delayed somite formation 0.0928124005804828 0.233793262221723 0.865375062096374 0.666666666666667 27.3 27 3 abnormal nucleotide metabolism 0.0928124005804828 0.233793262221723 0.865375062096374 0.666666666666667 27.3 27 3 vestibular saccular macula degeneration 0.0928124005804828 0.233793262221723 0.865375062096374 0.666666666666667 27.3 27 3 stria vascularis degeneration 0.0928124005804828 0.233793262221723 0.865375062096374 0.666666666666667 27.3 27 3 abnormal cochlear outer hair cell physiology 0.0928124005804828 0.233793262221723 0.865375062096374 0.666666666666667 27.3 27 3 abnormal amacrine cell morphology 0.0928124005804828 0.233793262221723 0.865375062096374 0.666666666666667 27.3 27 3 abnormal somatic nervous system physiology 0.0928124005804828 0.233793262221723 0.865375062096374 0.666666666666667 27.3 27 3 abnormal thymus corticomedullary boundary morphology 0.0928124005804828 0.233793262221723 0.865375062096374 0.666666666666667 27.3 27 3 hydrometra 0.0928124005804828 0.233793262221723 0.865375062096374 0.666666666666667 27.3 27 3 reduced cerebellar foliation 0.0928124005804828 0.233793262221723 0.865375062096374 0.666666666666667 27.3 27 3 decreased red blood cell distribution width 0.0928124005804828 0.233793262221723 0.865375062096374 0.666666666666667 27.3 27 3 renal tubular acidosis 0.143777609307004 0.324102223064044 0.865375062096374 0.666666666666667 27.3 27 3 synostosis 0.143777609307004 0.324102223064044 0.865375062096374 0.666666666666667 27.3 27 3 thick tail 0.143777609307004 0.324102223064044 0.865375062096374 0.666666666666667 27.3 27 3 wavy vibrissae 0.143777609307004 0.324102223064044 0.865375062096374 0.666666666666667 27.3 27 3 abnormal lung volume 0.143777609307004 0.324102223064044 0.865375062096374 0.666666666666667 27.3 27 3 abnormal postural reflex 0.143777609307004 0.324102223064044 0.865375062096374 0.666666666666667 27.3 27 3 decreased circulating bicarbonate level 0.143777609307004 0.324102223064044 0.865375062096374 0.666666666666667 27.3 27 3 enlarged otoliths 0.143777609307004 0.324102223064044 0.865375062096374 0.666666666666667 27.3 27 3 absent posterior semicircular canal 0.143777609307004 0.324102223064044 0.865375062096374 0.666666666666667 27.3 27 3 pancreas cysts 0.143777609307004 0.324102223064044 0.865375062096374 0.666666666666667 27.3 27 3 abnormal bony labyrinth 0.143777609307004 0.324102223064044 0.865375062096374 0.666666666666667 27.3 27 3 small scapula 0.143777609307004 0.324102223064044 0.865375062096374 0.666666666666667 27.3 27 3 decreased thyroid-stimulating hormone level 0.143777609307004 0.324102223064044 0.865375062096374 0.666666666666667 27.3 27 3 absent adrenal gland 0.143777609307004 0.324102223064044 0.865375062096374 0.666666666666667 27.3 27 3 positive geotaxis 0.143777609307004 0.324102223064044 0.865375062096374 0.666666666666667 27.3 27 3 decreased pulmonary ventilation 0.143777609307004 0.324102223064044 0.865375062096374 0.666666666666667 27.3 27 3 enhanced conditioned place preference behavior 0.143777609307004 0.324102223064044 0.865375062096374 0.666666666666667 27.3 27 3 abnormal retinal development 0.143777609307004 0.324102223064044 0.865375062096374 0.666666666666667 27.3 27 3 abnormal liver vasculature morphology 0.143777609307004 0.324102223064044 0.865375062096374 0.666666666666667 27.3 27 3 multiflagellated sperm 0.143777609307004 0.324102223064044 0.865375062096374 0.666666666666667 27.3 27 3 abnormal incisor color 0.143777609307004 0.324102223064044 0.865375062096374 0.666666666666667 27.3 27 3 prolonged RR interval 0.143777609307004 0.324102223064044 0.865375062096374 0.666666666666667 27.3 27 3 shortened ST segment 0.143777609307004 0.324102223064044 0.865375062096374 0.666666666666667 27.3 27 3 abnormal pulmonary alveolar parenchyma morphology 0.143777609307004 0.324102223064044 0.865375062096374 0.666666666666667 27.3 27 3 abnormal oxidative phosphorylation 0.143777609307004 0.324102223064044 0.865375062096374 0.666666666666667 27.3 27 3 increased core body temperature 0.143777609307004 0.324102223064044 0.865375062096374 0.666666666666667 27.3 27 3 decreased bone trabecular spacing 0.143777609307004 0.324102223064044 0.865375062096374 0.666666666666667 27.3 27 3 decreased fatty acid oxidation 0.143777609307004 0.324102223064044 0.865375062096374 0.666666666666667 27.3 27 3 lethargy 5.54373460209481e-06 7.92531024293726e-05 0.865375062096373 0.666666666666667 27.3 27 3 decreased insulin secretion 7.81269858884579e-06 0.00010826789827161 0.865375062096373 0.666666666666667 27.3 27 3 abnormal cell migration 0.00145661134032601 0.0102065372086224 0.865375062096373 0.666666666666667 27.3 27 3 cardiomyopathy 0.00145661134032601 0.0102065372086224 0.865375062096373 0.666666666666667 27.3 27 3 decreased bone mineral density 2.61068228628062e-14 1.64406890813242e-12 0.863748417242809 0.665413533834586 27.3 27 3 abnormal lens morphology 1.43216863969682e-07 2.96876624270487e-06 0.86199469076006 0.6640625 27.3 27 3 increased spleen weight 7.84351299263919e-07 1.36917463643439e-05 0.861545968901257 0.663716814159292 27.3 27 3 decreased cardiac muscle contractility 2.18258047999369e-06 3.4145716628832e-05 0.861214605067064 0.663461538461538 27.3 27 3 improved glucose tolerance 9.2702311844574e-11 3.60307813614653e-09 0.860959883208127 0.663265306122449 27.3 27 3 short tail 2.40722955300964e-05 0.000285822602057827 0.86016195931266 0.662650602409639 27.3 27 3 increased granulocyte number 6.78451104408502e-05 0.00071814771158134 0.859527933298425 0.662162162162162 27.3 27 3 abnormal spleen morphology 1.50822273782149e-09 4.68963007541368e-08 0.857914932250715 0.660919540229885 27.3 27 3 abnormal testis morphology 8.59109397408081e-07 1.49442980842839e-05 0.857850061556405 0.660869565217391 27.3 27 3 abnormal seminal vesicle morphology 0.000550012735284954 0.00440462195441066 0.857648499041942 0.660714285714286 27.3 27 3 extramedullary hematopoiesis 2.38876562210893e-06 3.69071707142607e-05 0.857211146416219 0.660377358490566 27.3 27 3 decreased heart rate 4.73058172398619e-06 6.90165515449599e-05 0.85672131147541 0.66 27.3 27 3 increased body length 0.00111434427493144 0.00805794006945339 0.85672131147541 0.66 27.3 27 3 kidney inflammation 0.00111434427493144 0.00805794006945339 0.85672131147541 0.66 27.3 27 3 decreased bone trabecula number 0.00158958489151238 0.0108796540935905 0.856168944414497 0.659574468085106 27.3 27 3 abnormal myelopoiesis 0.0022713430122847 0.0146562016681146 0.855541254572551 0.659090909090909 27.3 27 3 abnormal cholesterol homeostasis 0.00325174820933127 0.0194440472853643 0.854821707680564 0.658536585365854 27.3 27 3 abnormal axial skeleton morphology 7.39610063887796e-05 0.000776278495325271 0.853988548121421 0.657894736842105 27.3 27 3 impaired branching involved in ureteric bud morphogenesis 0.00466560921086085 0.0257618266637433 0.853988548121421 0.657894736842105 27.3 27 3 thick pulmonary interalveolar septum 0.00671131141767922 0.0340642630849788 0.853012561209282 0.657142857142857 27.3 27 3 ovary cysts 0.00671131141767922 0.0340642630849788 0.853012561209282 0.657142857142857 27.3 27 3 decreased bone mineralization 0.00671131141767922 0.0340642630849788 0.853012561209282 0.657142857142857 27.3 27 3 kinked tail 5.151635730172e-06 7.40733750219818e-05 0.852648958242015 0.656862745098039 27.3 27 3 increased circulating insulin level 1.35862754783366e-08 3.44855716860839e-07 0.851853576751118 0.65625 27.3 27 3 increased circulating follicle stimulating hormone level 0.00968282464888366 0.0453597482374729 0.851853576751118 0.65625 27.3 27 3 abnormal heart atrium morphology 0.00968282464888366 0.0453597482374729 0.851853576751118 0.65625 27.3 27 3 bradykinesia 0.00968282464888366 0.0453597482374729 0.851853576751118 0.65625 27.3 27 3 abnormal enzyme/coenzyme activity 1.90407922847845e-08 4.68950206023777e-07 0.85159520441968 0.656050955414013 27.3 27 3 small testis 1.04866521089479e-13 5.92853343659272e-12 0.851265686083933 0.655797101449275 27.3 27 3 decreased B cell number 1.43754956258801e-10 5.33717095065325e-09 0.850672087740367 0.655339805825243 27.3 27 3 increased leukocyte cell number 7.35320544113794e-08 1.60448232761672e-06 0.850454802405057 0.655172413793103 27.3 27 3 cochlear ganglion degeneration 0.000596950052683272 0.0046916690554491 0.850454802405057 0.655172413793103 27.3 27 3 glomerulosclerosis 0.000596950052683272 0.0046916690554491 0.850454802405057 0.655172413793103 27.3 27 3 increased retinal apoptosis 0.0140194863460302 0.0615595274240956 0.850454802405057 0.655172413793103 27.3 27 3 increased food intake 4.02583660854451e-05 0.000455791525041845 0.84992193598751 0.654761904761905 27.3 27 3 cachexia 5.58699230396203e-06 7.96426553358484e-05 0.848733233979136 0.653846153846154 27.3 27 3 increased circulating alanine transaminase level 8.01807163491483e-05 0.000832774663542824 0.848733233979136 0.653846153846154 27.3 27 3 absent corpus luteum 0.00120681990291085 0.00866367823518251 0.848733233979136 0.653846153846154 27.3 27 3 spleen hyperplasia 0.000113251492395862 0.00112460314305272 0.848067560854446 0.653333333333333 27.3 27 3 abnormal respiratory system physiology 0.00171928402755316 0.0115275445243625 0.847714346543386 0.653061224489796 27.3 27 3 decreased circulating creatinine level 0.00171928402755316 0.0115275445243625 0.847714346543386 0.653061224489796 27.3 27 3 abnormal inner ear morphology 0.00245308939002778 0.0155466493189658 0.846562560746452 0.652173913043478 27.3 27 3 conjunctivitis 0.029795686883678 0.107727865004577 0.846562560746452 0.652173913043478 27.3 27 3 increased susceptibility to age related obesity 0.029795686883678 0.107727865004577 0.846562560746452 0.652173913043478 27.3 27 3 abnormal Wolffian duct morphology 0.029795686883678 0.107727865004577 0.846562560746452 0.652173913043478 27.3 27 3 abnormal ulna morphology 0.029795686883678 0.107727865004577 0.846562560746452 0.652173913043478 27.3 27 3 abnormal chondrocyte physiology 0.029795686883678 0.107727865004577 0.846562560746452 0.652173913043478 27.3 27 3 male infertility 4.96708571455164e-23 7.722266071842e-21 0.846450358949137 0.652087475149105 27.3 27 3 abnormal male reproductive system morphology 0.00350610331056335 0.0201884999653387 0.845250060652272 0.651162790697674 27.3 27 3 abnormal blood circulation 0.00350610331056335 0.0201884999653387 0.845250060652272 0.651162790697674 27.3 27 3 abnormal hair follicle morphology 0.000453843395924454 0.00371360344527 0.844770893951222 0.650793650793651 27.3 27 3 increased circulating aspartate transaminase level 0.000453843395924454 0.00371360344527 0.844770893951222 0.650793650793651 27.3 27 3 enlarged liver 1.19293578465085e-05 0.000157423223571299 0.843740685543964 0.65 27.3 27 3 abnormal cell proliferation 0.0438369781996466 0.141340872678705 0.843740685543964 0.65 27.3 27 3 abnormal fibula morphology 0.0438369781996466 0.141340872678705 0.843740685543964 0.65 27.3 27 3 absent placental labyrinth 0.0438369781996466 0.141340872678705 0.843740685543964 0.65 27.3 27 3 dilated vasculature 0.0438369781996466 0.141340872678705 0.843740685543964 0.65 27.3 27 3 decreased circulating VLDL cholesterol level 0.0438369781996466 0.141340872678705 0.843740685543964 0.65 27.3 27 3 abnormal induced retinal neovascularization 0.0438369781996466 0.141340872678705 0.843740685543964 0.65 27.3 27 3 increased B cell number 2.34694475092227e-06 3.63739879621131e-05 0.843185957940056 0.64957264957265 27.3 27 3 abnormal blood homeostasis 3.29460833557037e-06 4.92212506590468e-05 0.842602034146469 0.649122807017544 27.3 27 3 increased erythroid progenitor cell number 0.00720632066151632 0.0352868556014209 0.84198654690458 0.648648648648649 27.3 27 3 abnormal locomotor activation 3.32238497093615e-05 0.000386188439962789 0.841601021928891 0.648351648351648 27.3 27 3 azoospermia 5.09267428496401e-08 1.16220433796771e-06 0.84088331505591 0.647798742138365 27.3 27 3 short femur 4.67764302813032e-05 0.000514851196127176 0.840790543286817 0.647727272727273 27.3 27 3 spleen hypoplasia 9.12533446282769e-06 0.000124379558774158 0.840650060322191 0.647619047619048 27.3 27 3 abnormal lung morphology 2.52275262983196e-06 3.84990623724356e-05 0.839922854387657 0.647058823529412 27.3 27 3 abnormal adipose tissue morphology 0.065043494544628 0.192728639285005 0.839922854387657 0.647058823529412 27.3 27 3 increased incidence of corneal inflammation 0.065043494544628 0.192728639285005 0.839922854387657 0.647058823529412 27.3 27 3 abnormal heart rate 0.065043494544628 0.192728639285005 0.839922854387657 0.647058823529412 27.3 27 3 abnormal dorsal-ventral axis patterning 0.065043494544628 0.192728639285005 0.839922854387657 0.647058823529412 27.3 27 3 enhanced behavioral response to cocaine 0.065043494544628 0.192728639285005 0.839922854387657 0.647058823529412 27.3 27 3 increased hepatoma incidence 0.065043494544628 0.192728639285005 0.839922854387657 0.647058823529412 27.3 27 3 increased trabecular bone mass 0.065043494544628 0.192728639285005 0.839922854387657 0.647058823529412 27.3 27 3 decreased body fat mass 0.065043494544628 0.192728639285005 0.839922854387657 0.647058823529412 27.3 27 3 abnormal cell cytoskeleton morphology 0.065043494544628 0.192728639285005 0.839922854387657 0.647058823529412 27.3 27 3 increased kidney weight 0.00184505568224794 0.0120937444258017 0.839922854387657 0.647058823529412 27.3 27 3 female infertility 2.62104707833028e-12 1.3583030431972e-10 0.83934874443934 0.646616541353383 27.3 27 3 decreased T cell number 5.46720705558928e-08 1.24197968500259e-06 0.838500060167915 0.645962732919255 27.3 27 3 abnormal phalanx morphology 0.00262775927112801 0.0165165498870577 0.838332091405862 0.645833333333333 27.3 27 3 abnormal visceral yolk sac morphology 0.000130860575020886 0.00126906697997838 0.837989775321172 0.645569620253165 27.3 27 3 decreased food intake 0.000130860575020886 0.00126906697997838 0.837989775321172 0.645569620253165 27.3 27 3 absent mature ovarian follicles 0.0149669501543946 0.0627260465087192 0.83745973751262 0.645161290322581 27.3 27 3 hypoglycemia 3.56170677807094e-05 0.000411404442554016 0.837459737512619 0.645161290322581 27.3 27 3 altered response to myocardial infarction 0.00374804416770985 0.0214532748988001 0.836529226693161 0.644444444444444 27.3 27 3 abnormal autopod morphology 0.00374804416770985 0.0214532748988001 0.836529226693161 0.644444444444444 27.3 27 3 small placenta 0.00374804416770985 0.0214532748988001 0.836529226693161 0.644444444444444 27.3 27 3 arrest of spermatogenesis 9.92144883467544e-05 0.000995145321623192 0.834468809878646 0.642857142857143 27.3 27 3 skin edema 0.00535485384543511 0.0291910347743065 0.834468809878646 0.642857142857143 27.3 27 3 abnormal cytotoxic T cell physiology 0.00535485384543511 0.0291910347743065 0.834468809878646 0.642857142857143 27.3 27 3 abnormal circulating cholesterol level 0.0216797601041796 0.0834744068119996 0.834468809878646 0.642857142857143 27.3 27 3 abnormal ovulation 0.0216797601041796 0.0834744068119996 0.834468809878646 0.642857142857143 27.3 27 3 increased bone resorption 0.0216797601041796 0.0834744068119996 0.834468809878646 0.642857142857143 27.3 27 3 abnormal zigzag hair morphology 0.0976129202540934 0.244277805967864 0.834468809878646 0.642857142857143 27.3 27 3 translucent skin 0.0976129202540934 0.244277805967864 0.834468809878646 0.642857142857143 27.3 27 3 extended life span 0.0976129202540934 0.244277805967864 0.834468809878646 0.642857142857143 27.3 27 3 absent otoliths 0.0976129202540934 0.244277805967864 0.834468809878646 0.642857142857143 27.3 27 3 decreased vascular permeability 0.0976129202540934 0.244277805967864 0.834468809878646 0.642857142857143 27.3 27 3 abnormal ventral body wall morphology 0.0976129202540934 0.244277805967864 0.834468809878646 0.642857142857143 27.3 27 3 failure of zygotic cell division 0.0976129202540934 0.244277805967864 0.834468809878646 0.642857142857143 27.3 27 3 abnormal pancreas development 0.0976129202540934 0.244277805967864 0.834468809878646 0.642857142857143 27.3 27 3 increased circulating growth hormone level 0.0976129202540934 0.244277805967864 0.834468809878646 0.642857142857143 27.3 27 3 decreased tongue size 0.0976129202540934 0.244277805967864 0.834468809878646 0.642857142857143 27.3 27 3 increased lung compliance 0.0976129202540934 0.244277805967864 0.834468809878646 0.642857142857143 27.3 27 3 abnormal coat/ hair morphology 0.00196638204596412 0.0128551257275578 0.832719399375756 0.641509433962264 27.3 27 3 abnormal spermatogenesis 1.34081647705831e-08 3.4208010119821e-07 0.832453184734012 0.641304347826087 27.3 27 3 abnormal heart ventricle morphology 0.000196773327591915 0.00181286537920329 0.832091405861898 0.641025641025641 27.3 27 3 small lens 0.007664973051956 0.0368081476191902 0.832091405861898 0.641025641025641 27.3 27 3 decreased neutrophil cell number 5.66773720232332e-06 8.03333121981725e-05 0.832091405861898 0.641025641025641 27.3 27 3 abnormal inner ear vestibule morphology 0.0315387186010175 0.113864386821525 0.830760059612519 0.64 27.3 27 3 decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 0.0315387186010175 0.113864386821525 0.830760059612519 0.64 27.3 27 3 abnormal male meiosis 0.00103852991829437 0.00762048133261728 0.82990887102685 0.639344262295082 27.3 27 3 abnormal cardiovascular system physiology 1.67238954274666e-06 2.68391547585956e-05 0.829588875317952 0.639097744360902 27.3 27 3 abnormal heart left ventricle morphology 0.00039091535199271 0.00327408059960224 0.829317767842358 0.638888888888889 27.3 27 3 abnormal reflex 0.0109953674344294 0.0500475324668675 0.829317767842358 0.638888888888889 27.3 27 3 abnormal tibia morphology 0.00397692085799615 0.0226634378791877 0.828550591368868 0.638297872340426 27.3 27 3 abnormal eye electrophysiology 6.39526711280342e-06 9.0387653085787e-05 0.826039832001084 0.636363636363636 27.3 27 3 abnormal circadian rhythm 0.00566693383255103 0.0307113244193261 0.826039832001084 0.636363636363636 27.3 27 3 decreased sensitivity to xenobiotic induced morbidity/mortality 0.0158119861581675 0.0635417052801964 0.826039832001084 0.636363636363636 27.3 27 3 abnormal abdominal fat pad morphology 0.0461232497569553 0.147469902018543 0.826039832001084 0.636363636363636 27.3 27 3 abnormal long bone epiphysis morphology 0.0461232497569553 0.147469902018543 0.826039832001084 0.636363636363636 27.3 27 3 abnormal enterocyte morphology 0.0461232497569553 0.147469902018543 0.826039832001084 0.636363636363636 27.3 27 3 abnormal chorion morphology 0.0461232497569553 0.147469902018543 0.826039832001084 0.636363636363636 27.3 27 3 increased coping response 0.0461232497569553 0.147469902018543 0.826039832001084 0.636363636363636 27.3 27 3 aphakia 0.0461232497569553 0.147469902018543 0.826039832001084 0.636363636363636 27.3 27 3 decreased cardiac output 0.0461232497569553 0.147469902018543 0.826039832001084 0.636363636363636 27.3 27 3 abnormal circulating lipid level 0.0461232497569553 0.147469902018543 0.826039832001084 0.636363636363636 27.3 27 3 abnormal sperm midpiece morphology 0.0461232497569553 0.147469902018543 0.826039832001084 0.636363636363636 27.3 27 3 pulmonary vascular congestion 0.0461232497569553 0.147469902018543 0.826039832001084 0.636363636363636 27.3 27 3 absent semicircular canals 0.148872043989651 0.331530178535592 0.826039832001084 0.636363636363636 27.3 27 3 abnormal stomach epithelium morphology 0.148872043989651 0.331530178535592 0.826039832001084 0.636363636363636 27.3 27 3 abnormal enteric ganglia morphology 0.148872043989651 0.331530178535592 0.826039832001084 0.636363636363636 27.3 27 3 impaired myelopoiesis 0.148872043989651 0.331530178535592 0.826039832001084 0.636363636363636 27.3 27 3 secondary sex reversal 0.148872043989651 0.331530178535592 0.826039832001084 0.636363636363636 27.3 27 3 fused joints 0.148872043989651 0.331530178535592 0.826039832001084 0.636363636363636 27.3 27 3 impaired luteinization 0.148872043989651 0.331530178535592 0.826039832001084 0.636363636363636 27.3 27 3 abnormal lymph circulation 0.148872043989651 0.331530178535592 0.826039832001084 0.636363636363636 27.3 27 3 abnormal ureter development 0.148872043989651 0.331530178535592 0.826039832001084 0.636363636363636 27.3 27 3 abnormal crista ampullaris neuroepithelium morphology 0.148872043989651 0.331530178535592 0.826039832001084 0.636363636363636 27.3 27 3 abnormal Bruch membrane morphology 0.148872043989651 0.331530178535592 0.826039832001084 0.636363636363636 27.3 27 3 increased circulating triiodothyronine level 0.148872043989651 0.331530178535592 0.826039832001084 0.636363636363636 27.3 27 3 abnormal superovulation 0.148872043989651 0.331530178535592 0.826039832001084 0.636363636363636 27.3 27 3 increased number of Howell-Jolly bodies 0.148872043989651 0.331530178535592 0.826039832001084 0.636363636363636 27.3 27 3 shortened PR interval 0.148872043989651 0.331530178535592 0.826039832001084 0.636363636363636 27.3 27 3 decreased core body temperature 0.148872043989651 0.331530178535592 0.826039832001084 0.636363636363636 27.3 27 3 abnormal brain ependyma motile cilium morphology 0.148872043989651 0.331530178535592 0.826039832001084 0.636363636363636 27.3 27 3 chylous ascites 0.148872043989651 0.331530178535592 0.826039832001084 0.636363636363636 27.3 27 3 small seminiferous tubules 0.000413801664599963 0.00340838291620003 0.824445160510734 0.635135135135135 27.3 27 3 abnormal skin condition 0.00295357045688605 0.0180073689007452 0.823770491803279 0.634615384615385 27.3 27 3 abnormal leukocyte migration 0.00295357045688605 0.0180073689007452 0.823770491803279 0.634615384615385 27.3 27 3 increased total body fat amount 2.62567289416483e-06 3.98253739282623e-05 0.823397913561848 0.634328358208955 27.3 27 3 arrested B cell differentiation 0.00808749252719952 0.0386506006943493 0.823161644433136 0.634146341463415 27.3 27 3 increased bone trabecula number 0.00808749252719952 0.0386506006943493 0.823161644433136 0.634146341463415 27.3 27 3 abnormal hair cycle 0.0228042339285765 0.086603865492113 0.822106308991555 0.633333333333333 27.3 27 3 disorganized myocardium 0.0228042339285765 0.086603865492113 0.822106308991555 0.633333333333333 27.3 27 3 abnormal fat pad morphology 0.0228042339285765 0.086603865492113 0.822106308991555 0.633333333333333 27.3 27 3 organ of Corti degeneration 0.00419235552395133 0.0238365356933233 0.821223273213906 0.63265306122449 27.3 27 3 increased fluid intake 0.00419235552395133 0.0238365356933233 0.821223273213906 0.63265306122449 27.3 27 3 alopecia 8.89985213854033e-05 0.000901767095503832 0.819829006196564 0.631578947368421 27.3 27 3 irregular coat pigmentation 0.0678978344291262 0.199758560783503 0.819829006196564 0.631578947368421 27.3 27 3 enlarged adrenal glands 0.0678978344291262 0.199758560783503 0.819829006196564 0.631578947368421 27.3 27 3 flaky skin 0.0678978344291262 0.199758560783503 0.819829006196564 0.631578947368421 27.3 27 3 thin dermal layer 0.0678978344291262 0.199758560783503 0.819829006196564 0.631578947368421 27.3 27 3 short vibrissae 0.0678978344291262 0.199758560783503 0.819829006196564 0.631578947368421 27.3 27 3 decreased grooming behavior 0.0678978344291262 0.199758560783503 0.819829006196564 0.631578947368421 27.3 27 3 decreased tumor incidence 0.0678978344291262 0.199758560783503 0.819829006196564 0.631578947368421 27.3 27 3 osteoarthritis 0.0678978344291262 0.199758560783503 0.819829006196564 0.631578947368421 27.3 27 3 increased left ventricle weight 0.0678978344291262 0.199758560783503 0.819829006196564 0.631578947368421 27.3 27 3 decreased eye pigmentation 0.0678978344291262 0.199758560783503 0.819829006196564 0.631578947368421 27.3 27 3 decreased liver regeneration 0.0678978344291262 0.199758560783503 0.819829006196564 0.631578947368421 27.3 27 3 shortened RR interval 0.0678978344291262 0.199758560783503 0.819829006196564 0.631578947368421 27.3 27 3 hydronephrosis 0.000232793492378921 0.00210955851472702 0.819015683769782 0.630952380952381 27.3 27 3 increased circulating cholesterol level 1.3130870536867e-07 2.74479331600477e-06 0.818664476358217 0.630681818181818 27.3 27 3 abnormal sleep pattern 0.00595708467081459 0.0314946825051037 0.818343808721571 0.630434782608696 27.3 27 3 abnormal lymphocyte physiology 0.00595708467081459 0.0314946825051037 0.818343808721571 0.630434782608696 27.3 27 3 increased exploration in new environment 0.000326575693338552 0.00281092400408182 0.817298669757686 0.62962962962963 27.3 27 3 abnormal single cell response 0.033000177455127 0.11885727608641 0.817298669757686 0.62962962962963 27.3 27 3 abnormal palate morphology 0.033000177455127 0.11885727608641 0.817298669757686 0.62962962962963 27.3 27 3 abnormal bone trabecula morphology 0.033000177455127 0.11885727608641 0.817298669757686 0.62962962962963 27.3 27 3 increased urine protein level 0.000458198600517235 0.00373694760257909 0.81544957774466 0.628205128205128 27.3 27 3 impaired hematopoiesis 0.00439418813040247 0.0246183400323787 0.81447064667894 0.627450980392157 27.3 27 3 abnormal colon morphology 0.00230018184787344 0.0148038870545542 0.814039253327945 0.627118644067797 27.3 27 3 abnormal lipid level 0.000342405916778732 0.00292692342950892 0.813244034259243 0.626506024096386 27.3 27 3 decreased litter size 7.60167327618215e-11 3.0014543292862e-09 0.813021410652821 0.626334519572954 27.3 27 3 increased body weight 7.65334793756795e-09 2.02864645981307e-07 0.81128912071535 0.625 27.3 27 3 hyperglycemia 0.000255927086716735 0.00227770528875806 0.81128912071535 0.625 27.3 27 3 increased liver weight 0.000255927086716735 0.00227770528875806 0.81128912071535 0.625 27.3 27 3 abnormal kidney physiology 0.00622552350277637 0.0324994537526888 0.81128912071535 0.625 27.3 27 3 decreased circulating phosphate level 0.0120717232055979 0.0541052458989635 0.81128912071535 0.625 27.3 27 3 abnormal female reproductive system morphology 0.0120717232055979 0.0541052458989635 0.81128912071535 0.625 27.3 27 3 abnormal cellular extravasation 0.0479478051000111 0.153205093367087 0.81128912071535 0.625 27.3 27 3 abnormal hair follicle orientation 0.100802313914951 0.249995768557768 0.81128912071535 0.625 27.3 27 3 abnormal mouth morphology 0.100802313914951 0.249995768557768 0.81128912071535 0.625 27.3 27 3 abnormal pituitary gland morphology 0.100802313914951 0.249995768557768 0.81128912071535 0.625 27.3 27 3 mixed cellular infiltration to dermis 0.100802313914951 0.249995768557768 0.81128912071535 0.625 27.3 27 3 reduced male mating frequency 0.100802313914951 0.249995768557768 0.81128912071535 0.625 27.3 27 3 disorganized yolk sac vascular plexus 0.100802313914951 0.249995768557768 0.81128912071535 0.625 27.3 27 3 abnormal olfaction 0.100802313914951 0.249995768557768 0.81128912071535 0.625 27.3 27 3 impaired muscle relaxation 0.100802313914951 0.249995768557768 0.81128912071535 0.625 27.3 27 3 increased thymus weight 0.100802313914951 0.249995768557768 0.81128912071535 0.625 27.3 27 3 abnormal amnion morphology 0.100802313914951 0.249995768557768 0.81128912071535 0.625 27.3 27 3 abnormal level of surface class II molecules 0.100802313914951 0.249995768557768 0.81128912071535 0.625 27.3 27 3 abnormal Langerhans cell physiology 0.100802313914951 0.249995768557768 0.81128912071535 0.625 27.3 27 3 decreased creatinine clearance 0.100802313914951 0.249995768557768 0.81128912071535 0.625 27.3 27 3 kidney degeneration 0.100802313914951 0.249995768557768 0.81128912071535 0.625 27.3 27 3 abnormal ear pigmentation 0.232727326660815 0.409847238986744 0.81128912071535 0.625 27.3 27 3 schistocytosis 0.232727326660815 0.409847238986744 0.81128912071535 0.625 27.3 27 3 abnormal esophageal epithelium morphology 0.232727326660815 0.409847238986744 0.81128912071535 0.625 27.3 27 3 absent mammary gland 0.232727326660815 0.409847238986744 0.81128912071535 0.625 27.3 27 3 absent skin pigmentation 0.232727326660815 0.409847238986744 0.81128912071535 0.625 27.3 27 3 spinning 0.232727326660815 0.409847238986744 0.81128912071535 0.625 27.3 27 3 preneoplasia 0.232727326660815 0.409847238986744 0.81128912071535 0.625 27.3 27 3 abnormal pulmonary circulation 0.232727326660815 0.409847238986744 0.81128912071535 0.625 27.3 27 3 abnormal parturition 0.232727326660815 0.409847238986744 0.81128912071535 0.625 27.3 27 3 head spot 0.232727326660815 0.409847238986744 0.81128912071535 0.625 27.3 27 3 vascular smooth muscle hypertrophy 0.232727326660815 0.409847238986744 0.81128912071535 0.625 27.3 27 3 short ureter 0.232727326660815 0.409847238986744 0.81128912071535 0.625 27.3 27 3 altered response to CNS ischemic injury 0.232727326660815 0.409847238986744 0.81128912071535 0.625 27.3 27 3 abnormal soft palate morphology 0.232727326660815 0.409847238986744 0.81128912071535 0.625 27.3 27 3 abnormal umbilical artery morphology 0.232727326660815 0.409847238986744 0.81128912071535 0.625 27.3 27 3 decreased circulating renin level 0.232727326660815 0.409847238986744 0.81128912071535 0.625 27.3 27 3 abnormal platelet shape 0.232727326660815 0.409847238986744 0.81128912071535 0.625 27.3 27 3 abnormal forelimb zeugopod morphology 0.232727326660815 0.409847238986744 0.81128912071535 0.625 27.3 27 3 lymph node inflammation 0.232727326660815 0.409847238986744 0.81128912071535 0.625 27.3 27 3 long femur 0.232727326660815 0.409847238986744 0.81128912071535 0.625 27.3 27 3 bowed fibula 0.232727326660815 0.409847238986744 0.81128912071535 0.625 27.3 27 3 absent cochlear microphonics 0.232727326660815 0.409847238986744 0.81128912071535 0.625 27.3 27 3 abnormal kidney epithelium morphology 0.232727326660815 0.409847238986744 0.81128912071535 0.625 27.3 27 3 increased circulating prolactin level 0.232727326660815 0.409847238986744 0.81128912071535 0.625 27.3 27 3 non-pigmented tail tip 0.232727326660815 0.409847238986744 0.81128912071535 0.625 27.3 27 3 ectrodactyly 0.232727326660815 0.409847238986744 0.81128912071535 0.625 27.3 27 3 Sertoli cell hypoplasia 0.232727326660815 0.409847238986744 0.81128912071535 0.625 27.3 27 3 abnormal circulating corticosterone level 0.232727326660815 0.409847238986744 0.81128912071535 0.625 27.3 27 3 abnormal ilium morphology 0.232727326660815 0.409847238986744 0.81128912071535 0.625 27.3 27 3 stomach epithelial hyperplasia 0.232727326660815 0.409847238986744 0.81128912071535 0.625 27.3 27 3 increased pulmonary ventilation 0.232727326660815 0.409847238986744 0.81128912071535 0.625 27.3 27 3 abnormal thymus epithelium morphology 0.232727326660815 0.409847238986744 0.81128912071535 0.625 27.3 27 3 abnormal meiotic spindle morphology 0.232727326660815 0.409847238986744 0.81128912071535 0.625 27.3 27 3 abnormal sphingomyelin level 0.232727326660815 0.409847238986744 0.81128912071535 0.625 27.3 27 3 abnormal frontonasal prominence morphology 0.232727326660815 0.409847238986744 0.81128912071535 0.625 27.3 27 3 skin fibrosis 0.232727326660815 0.409847238986744 0.81128912071535 0.625 27.3 27 3 abnormal sensory neuron physiology 0.232727326660815 0.409847238986744 0.81128912071535 0.625 27.3 27 3 decreased serotonin level 0.232727326660815 0.409847238986744 0.81128912071535 0.625 27.3 27 3 decreased quadriceps weight 0.232727326660815 0.409847238986744 0.81128912071535 0.625 27.3 27 3 ostium secundum atrial septal defect 0.232727326660815 0.409847238986744 0.81128912071535 0.625 27.3 27 3 abnormal visual evoked potential 0.232727326660815 0.409847238986744 0.81128912071535 0.625 27.3 27 3 abnormal heart right ventricle pressure 0.232727326660815 0.409847238986744 0.81128912071535 0.625 27.3 27 3 abnormal maxillary prominence morphology 0.232727326660815 0.409847238986744 0.81128912071535 0.625 27.3 27 3 abnormal kidney mesenchyme morphology 0.232727326660815 0.409847238986744 0.81128912071535 0.625 27.3 27 3 absent Reichert's membrane 0.232727326660815 0.409847238986744 0.81128912071535 0.625 27.3 27 3 decreased cranium length 0.232727326660815 0.409847238986744 0.81128912071535 0.625 27.3 27 3 abnormal heart echocardiography feature 0.232727326660815 0.409847238986744 0.81128912071535 0.625 27.3 27 3 shortened PQ interval 0.232727326660815 0.409847238986744 0.81128912071535 0.625 27.3 27 3 increased brain apoptosis 0.232727326660815 0.409847238986744 0.81128912071535 0.625 27.3 27 3 abnormal T cell differentiation 0.000102599612948332 0.00102702831874839 0.809682607605023 0.623762376237624 27.3 27 3 decreased hematocrit 3.53003599177361e-06 5.25806259253704e-05 0.809066410795582 0.623287671232877 27.3 27 3 abnormal lipid homeostasis 1.20477103149805e-05 0.000158564441314888 0.808792846497765 0.623076923076923 27.3 27 3 increased osteoclast cell number 0.00240067051058464 0.0153710885330226 0.808629156385136 0.622950819672131 27.3 27 3 weight loss 4.252477449212e-07 7.9236237115467e-06 0.808507558015755 0.622857142857143 27.3 27 3 abnormal spermiogenesis 0.00337900741616713 0.0196881944779459 0.805694023331106 0.620689655172414 27.3 27 3 thrombocytosis 0.00337900741616713 0.0196881944779459 0.805694023331106 0.620689655172414 27.3 27 3 abnormal CD8-positive, alpha-beta T cell physiology 0.0342147535266057 0.120907692443798 0.805694023331106 0.620689655172414 27.3 27 3 increased bone mineral density 5.99208252961912e-05 0.000639712673494745 0.804109570974506 0.619469026548673 27.3 27 3 abnormal vibrissa morphology 0.0125280303850667 0.0560998660357396 0.803562557660918 0.619047619047619 27.3 27 3 small ears 0.0700062819237518 0.205233501809467 0.803562557660918 0.619047619047619 27.3 27 3 hypoalgesia 0.0700062819237518 0.205233501809467 0.803562557660918 0.619047619047619 27.3 27 3 abnormal tumor vascularization 0.0700062819237518 0.205233501809467 0.803562557660918 0.619047619047619 27.3 27 3 vascular ring 0.0700062819237518 0.205233501809467 0.803562557660918 0.619047619047619 27.3 27 3 decreased vocalization 0.0700062819237518 0.205233501809467 0.803562557660918 0.619047619047619 27.3 27 3 abnormal vision 0.0246033458243187 0.0932939371005986 0.801744542824581 0.617647058823529 27.3 27 3 abnormal spleen red pulp morphology 0.0246033458243187 0.0932939371005986 0.801744542824581 0.617647058823529 27.3 27 3 abnormal dendritic cell physiology 0.000115634857619853 0.00114143535051343 0.800674122874215 0.616822429906542 27.3 27 3 increased susceptibility to injury 0.00669917640802878 0.0340642630849788 0.798807749627422 0.615384615384615 27.3 27 3 increased vascular permeability 0.0177967907311631 0.0709447386919363 0.798807749627422 0.615384615384615 27.3 27 3 impaired macrophage chemotaxis 0.0177967907311631 0.0709447386919363 0.798807749627422 0.615384615384615 27.3 27 3 abnormal ocular fundus morphology 0.0493847316545483 0.156193922281023 0.798807749627422 0.615384615384615 27.3 27 3 abnormal erythrocyte osmotic lysis 0.0493847316545483 0.156193922281023 0.798807749627422 0.615384615384615 27.3 27 3 abnormal nerve conduction 0.0493847316545483 0.156193922281023 0.798807749627422 0.615384615384615 27.3 27 3 absent teeth 0.151351681436978 0.332473789392572 0.798807749627422 0.615384615384615 27.3 27 3 short hair 0.151351681436978 0.332473789392572 0.798807749627422 0.615384615384615 27.3 27 3 abnormal renal/urinary system morphology 0.151351681436978 0.332473789392572 0.798807749627422 0.615384615384615 27.3 27 3 uterus hypoplasia 0.151351681436978 0.332473789392572 0.798807749627422 0.615384615384615 27.3 27 3 pup cannibalization 0.151351681436978 0.332473789392572 0.798807749627422 0.615384615384615 27.3 27 3 abnormal intercostal muscle morphology 0.151351681436978 0.332473789392572 0.798807749627422 0.615384615384615 27.3 27 3 abnormal otolith morphology 0.151351681436978 0.332473789392572 0.798807749627422 0.615384615384615 27.3 27 3 absent lateral semicircular canal 0.151351681436978 0.332473789392572 0.798807749627422 0.615384615384615 27.3 27 3 abnormal insulin secretion 0.151351681436978 0.332473789392572 0.798807749627422 0.615384615384615 27.3 27 3 muscle fatigue 0.151351681436978 0.332473789392572 0.798807749627422 0.615384615384615 27.3 27 3 small otic vesicle 0.151351681436978 0.332473789392572 0.798807749627422 0.615384615384615 27.3 27 3 increased circulating thyroid-stimulating hormone level 0.151351681436978 0.332473789392572 0.798807749627422 0.615384615384615 27.3 27 3 decreased cardiac stroke volume 0.151351681436978 0.332473789392572 0.798807749627422 0.615384615384615 27.3 27 3 small ovary 0.000401744431980223 0.00335348749849264 0.798807749627422 0.615384615384615 27.3 27 3 osteoporosis 0.0129338872314409 0.0578131976427841 0.796538409429617 0.613636363636364 27.3 27 3 decreased macrophage cell number 0.0129338872314409 0.0578131976427841 0.796538409429617 0.613636363636364 27.3 27 3 decreased double-negative T cell number 0.0352132665710311 0.120907692443798 0.795586750636989 0.612903225806452 27.3 27 3 abnormal small intestine morphology 0.00690570227624531 0.0345632483142056 0.793260473588342 0.611111111111111 27.3 27 3 decreased tumor growth/size 0.00690570227624531 0.0345632483142056 0.793260473588342 0.611111111111111 27.3 27 3 abnormal osteoblast physiology 0.00690570227624531 0.0345632483142056 0.793260473588342 0.611111111111111 27.3 27 3 impaired wound healing 0.0253066389595843 0.0953892269581598 0.793260473588342 0.611111111111111 27.3 27 3 head tilt 0.0253066389595843 0.0953892269581598 0.793260473588342 0.611111111111111 27.3 27 3 lowered ear position 0.102826420771269 0.253499228611033 0.793260473588342 0.611111111111111 27.3 27 3 abnormal heart shape 0.102826420771269 0.253499228611033 0.793260473588342 0.611111111111111 27.3 27 3 underdeveloped hair follicles 0.102826420771269 0.253499228611033 0.793260473588342 0.611111111111111 27.3 27 3 abnormal retinal rod cell morphology 0.102826420771269 0.253499228611033 0.793260473588342 0.611111111111111 27.3 27 3 eye inflammation 0.102826420771269 0.253499228611033 0.793260473588342 0.611111111111111 27.3 27 3 abnormal thymus medulla morphology 0.102826420771269 0.253499228611033 0.793260473588342 0.611111111111111 27.3 27 3 abnormal white adipose tissue morphology 0.102826420771269 0.253499228611033 0.793260473588342 0.611111111111111 27.3 27 3 decreased tumor latency 0.102826420771269 0.253499228611033 0.793260473588342 0.611111111111111 27.3 27 3 abnormal metanephric mesenchyme morphology 0.102826420771269 0.253499228611033 0.793260473588342 0.611111111111111 27.3 27 3 impaired leukocyte tethering or rolling 0.102826420771269 0.253499228611033 0.793260473588342 0.611111111111111 27.3 27 3 abnormal response/metabolism to endogenous compounds 0.00107952935902161 0.00788642960518722 0.791501581185707 0.609756097560976 27.3 27 3 decreased eosinophil cell number 0.00372729593863387 0.0214373379129521 0.791006892697466 0.609375 27.3 27 3 increased sensitivity to xenobiotic induced morbidity/mortality 0.000176780332509688 0.00164697032628408 0.790638124915323 0.609090909090909 27.3 27 3 abnormal blood vessel physiology 0.0715216808931643 0.208082083300288 0.790125056696689 0.608695652173913 27.3 27 3 abnormal carpal bone morphology 0.0715216808931643 0.208082083300288 0.790125056696689 0.608695652173913 27.3 27 3 abnormal retinal cone cell morphology 0.0715216808931643 0.208082083300288 0.790125056696689 0.608695652173913 27.3 27 3 abnormal innervation pattern to muscle 0.0715216808931643 0.208082083300288 0.790125056696689 0.608695652173913 27.3 27 3 blistering 0.0715216808931643 0.208082083300288 0.790125056696689 0.608695652173913 27.3 27 3 abnormal circulating insulin level 0.0715216808931643 0.208082083300288 0.790125056696689 0.608695652173913 27.3 27 3 hypotension 0.0715216808931643 0.208082083300288 0.790125056696689 0.608695652173913 27.3 27 3 abnormal crista ampullaris morphology 0.0715216808931643 0.208082083300288 0.790125056696689 0.608695652173913 27.3 27 3 decreased epididymis weight 0.0715216808931643 0.208082083300288 0.790125056696689 0.608695652173913 27.3 27 3 dilated heart 0.0715216808931643 0.208082083300288 0.790125056696689 0.608695652173913 27.3 27 3 abnormal B cell morphology 0.0715216808931643 0.208082083300288 0.790125056696689 0.608695652173913 27.3 27 3 abnormal hepatocyte physiology 0.0715216808931643 0.208082083300288 0.790125056696689 0.608695652173913 27.3 27 3 increased T cell proliferation 0.000244231661552275 0.00218534625219886 0.78854269677006 0.607476635514019 27.3 27 3 enhanced coordination 0.0504953679065908 0.158795483777048 0.788109431552054 0.607142857142857 27.3 27 3 dilated heart atrium 0.0360228103642135 0.121418347941709 0.786704601905794 0.606060606060606 27.3 27 3 abnormal retinal outer nuclear layer morphology 0.0258964494327255 0.0975282633821418 0.785669464271708 0.605263157894737 27.3 27 3 abnormal homeostasis 0.0187273633446503 0.0744753258510272 0.784875056319967 0.604651162790698 27.3 27 3 abnormal B cell differentiation 0.000844247948364145 0.00630650682148892 0.784543325526932 0.604395604395604 27.3 27 3 abnormal pancreatic islet morphology 0.00992469270992831 0.0464490557214425 0.783735905294829 0.60377358490566 27.3 27 3 skin lesions 0.00532816111542929 0.0291910347743065 0.782958389515767 0.603174603174603 27.3 27 3 teratozoospermia 0.00116635951631611 0.00842182669618673 0.781787698143883 0.602272727272727 27.3 27 3 abnormal kidney development 0.00741364079954189 0.0360889070232103 0.778837555886736 0.6 27.3 27 3 abnormal eye physiology 0.00741364079954189 0.0360889070232103 0.778837555886736 0.6 27.3 27 3 abnormal skin pigmentation 0.026384392019511 0.0992907339614731 0.778837555886736 0.6 27.3 27 3 increased red blood cell distribution width 0.0366670716861456 0.12342265334139 0.778837555886736 0.6 27.3 27 3 ruffled hair 0.0725614348485012 0.210361753377574 0.778837555886736 0.6 27.3 27 3 increased pre-B cell number 0.0725614348485012 0.210361753377574 0.778837555886736 0.6 27.3 27 3 abnormal keratinocyte physiology 0.0725614348485012 0.210361753377574 0.778837555886736 0.6 27.3 27 3 decreased placenta weight 0.0725614348485012 0.210361753377574 0.778837555886736 0.6 27.3 27 3 abnormal energy expenditure 0.0725614348485012 0.210361753377574 0.778837555886736 0.6 27.3 27 3 increased urine glucose level 0.103989118773346 0.254409201244034 0.778837555886736 0.6 27.3 27 3 brain inflammation 0.103989118773346 0.254409201244034 0.778837555886736 0.6 27.3 27 3 abnormal hair texture 0.103989118773346 0.254409201244034 0.778837555886736 0.6 27.3 27 3 abnormal male reproductive system physiology 0.103989118773346 0.254409201244034 0.778837555886736 0.6 27.3 27 3 abnormal physiological neovascularization 0.103989118773346 0.254409201244034 0.778837555886736 0.6 27.3 27 3 enhanced behavioral response to xenobiotic 0.103989118773346 0.254409201244034 0.778837555886736 0.6 27.3 27 3 abnormal sperm mitochondrial sheath morphology 0.103989118773346 0.254409201244034 0.778837555886736 0.6 27.3 27 3 abnormal respiratory system morphology 0.152169410743093 0.332473789392572 0.778837555886736 0.6 27.3 27 3 abnormal bronchus morphology 0.152169410743093 0.332473789392572 0.778837555886736 0.6 27.3 27 3 increased alcohol consumption 0.152169410743093 0.332473789392572 0.778837555886736 0.6 27.3 27 3 abnormal rostral migratory stream morphology 0.152169410743093 0.332473789392572 0.778837555886736 0.6 27.3 27 3 abnormal zygomatic bone morphology 0.152169410743093 0.332473789392572 0.778837555886736 0.6 27.3 27 3 abnormal neurotransmitter secretion 0.152169410743093 0.332473789392572 0.778837555886736 0.6 27.3 27 3 abnormal dendritic cell morphology 0.152169410743093 0.332473789392572 0.778837555886736 0.6 27.3 27 3 abnormal Muller cell morphology 0.152169410743093 0.332473789392572 0.778837555886736 0.6 27.3 27 3 abnormal microglial cell activation 0.152169410743093 0.332473789392572 0.778837555886736 0.6 27.3 27 3 abnormal auchene hair morphology 0.230860602163495 0.409847238986744 0.778837555886736 0.6 27.3 27 3 abnormal prostate gland epithelium morphology 0.230860602163495 0.409847238986744 0.778837555886736 0.6 27.3 27 3 abnormal epidermis suprabasal layer morphology 0.230860602163495 0.409847238986744 0.778837555886736 0.6 27.3 27 3 abnormal immune cell physiology 0.230860602163495 0.409847238986744 0.778837555886736 0.6 27.3 27 3 abnormal respiratory mechanics 0.230860602163495 0.409847238986744 0.778837555886736 0.6 27.3 27 3 abnormal primordial germ cell migration 0.230860602163495 0.409847238986744 0.778837555886736 0.6 27.3 27 3 abnormal bone healing 0.230860602163495 0.409847238986744 0.778837555886736 0.6 27.3 27 3 rickets 0.230860602163495 0.409847238986744 0.778837555886736 0.6 27.3 27 3 abnormal scala media morphology 0.230860602163495 0.409847238986744 0.778837555886736 0.6 27.3 27 3 abnormal hypaxial muscle morphology 0.230860602163495 0.409847238986744 0.778837555886736 0.6 27.3 27 3 absent CD4-positive, alpha beta T cells 0.230860602163495 0.409847238986744 0.778837555886736 0.6 27.3 27 3 abnormal hindlimb zeugopod morphology 0.230860602163495 0.409847238986744 0.778837555886736 0.6 27.3 27 3 abnormal ear physiology 0.230860602163495 0.409847238986744 0.778837555886736 0.6 27.3 27 3 abnormal placental transport 0.230860602163495 0.409847238986744 0.778837555886736 0.6 27.3 27 3 abnormal deltoid tuberosity morphology 0.230860602163495 0.409847238986744 0.778837555886736 0.6 27.3 27 3 decreased cochlear inner hair cell number 0.230860602163495 0.409847238986744 0.778837555886736 0.6 27.3 27 3 abnormal cochlear inner hair cell physiology 0.230860602163495 0.409847238986744 0.778837555886736 0.6 27.3 27 3 decreased prolactin level 0.230860602163495 0.409847238986744 0.778837555886736 0.6 27.3 27 3 tachypnea 0.230860602163495 0.409847238986744 0.778837555886736 0.6 27.3 27 3 abnormal developmental vascular remodeling 0.230860602163495 0.409847238986744 0.778837555886736 0.6 27.3 27 3 acanthocytosis 0.230860602163495 0.409847238986744 0.778837555886736 0.6 27.3 27 3 abnormal vibrissa follicle morphology 0.230860602163495 0.409847238986744 0.778837555886736 0.6 27.3 27 3 decreased macrophage apoptosis 0.230860602163495 0.409847238986744 0.778837555886736 0.6 27.3 27 3 decreased circulating calcium level 0.0101284058900094 0.0473134453547385 0.778837555886736 0.6 27.3 27 3 abnormal joint morphology 0.0101284058900094 0.0473134453547385 0.778837555886736 0.6 27.3 27 3 increased circulating corticosterone level 0.0190935310989918 0.0753293554460618 0.778837555886736 0.6 27.3 27 3 decreased IgM level 0.000901612087382226 0.00672491774321826 0.776161138168912 0.597938144329897 27.3 27 3 decreased compact bone thickness 0.00554247541225576 0.0301682879387007 0.774962742175857 0.597014925373134 27.3 27 3 absent vitelline blood vessels 0.0103071062133592 0.04805796945779 0.774282950296755 0.596491228070175 27.3 27 3 abnormal hair growth 0.0141158275639546 0.0619279031134691 0.773845007451565 0.596153846153846 27.3 27 3 abnormal response to infection 0.00305917289147423 0.0183694950289553 0.772265087060688 0.594936708860759 27.3 27 3 increased white adipose tissue amount 0.0371667054484116 0.124643172116341 0.771821001329198 0.594594594594595 27.3 27 3 decreased circulating chloride level 0.0371667054484116 0.124643172116341 0.771821001329198 0.594594594594595 27.3 27 3 skin inflammation 0.0371667054484116 0.124643172116341 0.771821001329198 0.594594594594595 27.3 27 3 increased trabecular bone volume 0.0371667054484116 0.124643172116341 0.771821001329198 0.594594594594595 27.3 27 3 rectal prolapse 0.0732168104900705 0.210361753377574 0.769222277418999 0.592592592592593 27.3 27 3 abnormal type II pneumocyte morphology 0.0732168104900705 0.210361753377574 0.769222277418999 0.592592592592593 27.3 27 3 liver inflammation 0.000396131645816099 0.00331219317300015 0.768020367610531 0.591666666666667 27.3 27 3 abnormal CD4-positive, alpha-beta T cell physiology 0.00571443397110873 0.0309350478849466 0.767868012846078 0.591549295774648 27.3 27 3 impaired swimming 0.0077723136597178 0.0372516960087631 0.767036986858149 0.590909090909091 27.3 27 3 abnormal skin morphology 0.0077723136597178 0.0372516960087631 0.767036986858149 0.590909090909091 27.3 27 3 increased body size 0.104503995053569 0.254409201244034 0.767036986858149 0.590909090909091 27.3 27 3 parakeratosis 0.104503995053569 0.254409201244034 0.767036986858149 0.590909090909091 27.3 27 3 abnormal channel response 0.104503995053569 0.254409201244034 0.767036986858149 0.590909090909091 27.3 27 3 decreased circulating estradiol level 0.104503995053569 0.254409201244034 0.767036986858149 0.590909090909091 27.3 27 3 abnormal temporal bone morphology 0.104503995053569 0.254409201244034 0.767036986858149 0.590909090909091 27.3 27 3 decreased susceptibility to viral infection induced morbidity/mortality 0.104503995053569 0.254409201244034 0.767036986858149 0.590909090909091 27.3 27 3 rough coat 0.104503995053569 0.254409201244034 0.767036986858149 0.590909090909091 27.3 27 3 increased bone volume 0.104503995053569 0.254409201244034 0.767036986858149 0.590909090909091 27.3 27 3 increased circulating glucose level 0.000171198073250527 0.00159795574938344 0.764107767595734 0.588652482269504 27.3 27 3 increased aggression towards mice 0.151886341586841 0.332473789392572 0.763566231261506 0.588235294117647 27.3 27 3 decreased vasoconstriction 0.151886341586841 0.332473789392572 0.763566231261506 0.588235294117647 27.3 27 3 abnormal duodenum morphology 0.151886341586841 0.332473789392572 0.763566231261506 0.588235294117647 27.3 27 3 aminoaciduria 0.151886341586841 0.332473789392572 0.763566231261506 0.588235294117647 27.3 27 3 abnormal melanosome morphology 0.151886341586841 0.332473789392572 0.763566231261506 0.588235294117647 27.3 27 3 pancytopenia 0.151886341586841 0.332473789392572 0.763566231261506 0.588235294117647 27.3 27 3 increased circulating magnesium level 0.151886341586841 0.332473789392572 0.763566231261506 0.588235294117647 27.3 27 3 abnormal survival 0.151886341586841 0.332473789392572 0.763566231261506 0.588235294117647 27.3 27 3 abnormal microglial cell morphology 0.0735595716115699 0.210361753377574 0.760933244257156 0.586206896551724 27.3 27 3 abnormal circulating glucose level 0.0735595716115699 0.210361753377574 0.760933244257156 0.586206896551724 27.3 27 3 decreased trophoblast giant cell number 0.0735595716115699 0.210361753377574 0.760933244257156 0.586206896551724 27.3 27 3 decreased bone strength 0.0735595716115699 0.210361753377574 0.760933244257156 0.586206896551724 27.3 27 3 scaly skin 0.0378017685544509 0.125543256714548 0.759841517938279 0.585365853658537 27.3 27 3 abnormal placenta development 0.0200215175855369 0.0784925531820695 0.759244158254366 0.584905660377358 27.3 27 3 polyuria 0.00590157662824346 0.03126767169916 0.758608008980587 0.584415584415584 27.3 27 3 abnormal urine homeostasis 0.0024325487860529 0.0155352120803764 0.757203179334327 0.583333333333333 27.3 27 3 abnormal inflammatory response 0.00800486181111483 0.0383293431282929 0.757203179334327 0.583333333333333 27.3 27 3 epidermal hyperplasia 0.0147305612438542 0.0624229490529598 0.757203179334327 0.583333333333333 27.3 27 3 abnormal adrenal gland morphology 0.104525107003579 0.254409201244034 0.757203179334327 0.583333333333333 27.3 27 3 small lymph nodes 0.104525107003579 0.254409201244034 0.757203179334327 0.583333333333333 27.3 27 3 increased circulating total protein level 0.104525107003579 0.254409201244034 0.757203179334327 0.583333333333333 27.3 27 3 abnormal inner cell mass apoptosis 0.104525107003579 0.254409201244034 0.757203179334327 0.583333333333333 27.3 27 3 abnormal mineral level 0.227355544762486 0.409847238986744 0.757203179334327 0.583333333333333 27.3 27 3 abnormal esophagus morphology 0.227355544762486 0.409847238986744 0.757203179334327 0.583333333333333 27.3 27 3 abnormal rectum morphology 0.227355544762486 0.409847238986744 0.757203179334327 0.583333333333333 27.3 27 3 decreased circulating ketone body level 0.227355544762486 0.409847238986744 0.757203179334327 0.583333333333333 27.3 27 3 decreased left ventricle systolic pressure 0.227355544762486 0.409847238986744 0.757203179334327 0.583333333333333 27.3 27 3 pale placenta 0.227355544762486 0.409847238986744 0.757203179334327 0.583333333333333 27.3 27 3 abnormal palatine bone morphology 0.227355544762486 0.409847238986744 0.757203179334327 0.583333333333333 27.3 27 3 abnormal patella morphology 0.227355544762486 0.409847238986744 0.757203179334327 0.583333333333333 27.3 27 3 impaired behavioral response to cocaine 0.227355544762486 0.409847238986744 0.757203179334327 0.583333333333333 27.3 27 3 abnormal aorta elastic tissue morphology 0.227355544762486 0.409847238986744 0.757203179334327 0.583333333333333 27.3 27 3 maternal effect 0.0108781597901114 0.0497915576290675 0.755588673621461 0.582089552238806 27.3 27 3 increased sensitivity to induced morbidity/mortality 4.41413030087071e-05 0.00048909350215661 0.754851616665587 0.581521739130435 27.3 27 3 decreased T cell proliferation 0.000243530190127418 0.00218299584843947 0.754279614935353 0.581081081081081 27.3 27 3 lung inflammation 0.000432251115082157 0.00355446164881608 0.754021653370737 0.580882352941177 27.3 27 3 abnormal circulating protein level 0.0276298647518616 0.103820677598574 0.752876304023845 0.58 27.3 27 3 abnormal epidermal layer morphology 0.0109375575756195 0.0498299898706109 0.752500053996847 0.579710144927536 27.3 27 3 abnormal triglyceride level 0.150853226991716 0.332473789392572 0.751509922346851 0.578947368421053 27.3 27 3 abnormal nail morphology 0.150853226991716 0.332473789392572 0.751509922346851 0.578947368421053 27.3 27 3 decreased chemically-elicited antinociception 0.150853226991716 0.332473789392572 0.751509922346851 0.578947368421053 27.3 27 3 abnormal photoreceptor inner segment morphology 0.150853226991716 0.332473789392572 0.751509922346851 0.578947368421053 27.3 27 3 eyelids fail to open 0.150853226991716 0.332473789392572 0.751509922346851 0.578947368421053 27.3 27 3 increased liver cholesterol level 0.150853226991716 0.332473789392572 0.751509922346851 0.578947368421053 27.3 27 3 decreased susceptibility to weight gain 0.150853226991716 0.332473789392572 0.751509922346851 0.578947368421053 27.3 27 3 thin interventricular septum 0.150853226991716 0.332473789392572 0.751509922346851 0.578947368421053 27.3 27 3 decreased osteoclast cell number 0.0380460783838996 0.126270340200067 0.749991720483524 0.577777777777778 27.3 27 3 abnormal kidney cortex morphology 0.104166030112982 0.254409201244034 0.748882265275708 0.576923076923077 27.3 27 3 abnormal ureter morphology 0.104166030112982 0.254409201244034 0.748882265275708 0.576923076923077 27.3 27 3 pulmonary edema 0.104166030112982 0.254409201244034 0.748882265275708 0.576923076923077 27.3 27 3 abnormal QRS complex 0.0735241013130973 0.210361753377574 0.747369371810504 0.575757575757576 27.3 27 3 increased osteoblast cell number 0.0735241013130973 0.210361753377574 0.747369371810504 0.575757575757576 27.3 27 3 increased susceptibility to weight loss 0.0526321962470639 0.164889909527168 0.746385991058122 0.575 27.3 27 3 sparse hair 0.00816897157486261 0.038927809947262 0.744011486314565 0.573170731707317 27.3 27 3 abnormal spleen white pulp morphology 0.0524961459777708 0.164567313320359 0.741750053225463 0.571428571428571 27.3 27 3 abnormal salivary gland morphology 0.149299567906138 0.332036365817182 0.741750053225463 0.571428571428571 27.3 27 3 trunk curl 0.149299567906138 0.332036365817182 0.741750053225463 0.571428571428571 27.3 27 3 abnormal associative learning 0.149299567906138 0.332036365817182 0.741750053225463 0.571428571428571 27.3 27 3 increased circulating serum albumin level 0.0732286770679535 0.210361753377574 0.741750053225463 0.571428571428571 27.3 27 3 abnormal intestinal goblet cell morphology 0.0732286770679535 0.210361753377574 0.741750053225463 0.571428571428571 27.3 27 3 impaired behavioral response to xenobiotic 0.0732286770679535 0.210361753377574 0.741750053225463 0.571428571428571 27.3 27 3 abnormal stria vascularis morphology 0.103512067268043 0.254409201244034 0.741750053225463 0.571428571428571 27.3 27 3 shortened head 0.103512067268043 0.254409201244034 0.741750053225463 0.571428571428571 27.3 27 3 reddish skin 0.103512067268043 0.254409201244034 0.741750053225463 0.571428571428571 27.3 27 3 corneal vascularization 0.103512067268043 0.254409201244034 0.741750053225463 0.571428571428571 27.3 27 3 megacephaly 0.223003363014157 0.409847238986744 0.741750053225463 0.571428571428571 27.3 27 3 abnormal vascular endothelial cell migration 0.223003363014157 0.409847238986744 0.741750053225463 0.571428571428571 27.3 27 3 abnormal imprinting 0.223003363014157 0.409847238986744 0.741750053225463 0.571428571428571 27.3 27 3 abnormal positive T cell selection 0.223003363014157 0.409847238986744 0.741750053225463 0.571428571428571 27.3 27 3 hypertension 0.0522703271448411 0.163962722285993 0.737535564286682 0.568181818181818 27.3 27 3 abnormal photoreceptor outer segment morphology 0.0522703271448411 0.163962722285993 0.737535564286682 0.568181818181818 27.3 27 3 decreased sensitivity to induced morbidity/mortality 0.0522703271448411 0.163962722285993 0.737535564286682 0.568181818181818 27.3 27 3 abnormal branching of the mammary ductal tree 0.0727907033254137 0.210361753377574 0.736738228541507 0.567567567567568 27.3 27 3 increased insulin secretion 0.0727907033254137 0.210361753377574 0.736738228541507 0.567567567567568 27.3 27 3 abnormal hair follicle development 0.0727907033254137 0.210361753377574 0.736738228541507 0.567567567567568 27.3 27 3 abnormal coat appearance 0.0201279404417987 0.0787856047977565 0.733687552646925 0.565217391304348 27.3 27 3 increased lymphocyte cell number 0.0201279404417987 0.0787856047977565 0.733687552646925 0.565217391304348 27.3 27 3 fragile skeleton 0.147381003462095 0.330875673386247 0.733687552646925 0.565217391304348 27.3 27 3 bidirectional circling 0.147381003462095 0.330875673386247 0.733687552646925 0.565217391304348 27.3 27 3 failure of embryo implantation 0.147381003462095 0.330875673386247 0.733687552646925 0.565217391304348 27.3 27 3 abnormal lens development 0.147381003462095 0.330875673386247 0.733687552646925 0.565217391304348 27.3 27 3 increased circulating calcium level 0.0374889332971195 0.124643172116341 0.731635279772389 0.563636363636364 27.3 27 3 abnormal T-helper 2 physiology 0.0374889332971195 0.124643172116341 0.731635279772389 0.563636363636364 27.3 27 3 abnormal lymph node morphology 0.0515994565556847 0.162165064033185 0.730160208643815 0.5625 27.3 27 3 increased dopamine level 0.101565132205366 0.251762099014299 0.730160208643815 0.5625 27.3 27 3 delayed hair appearance 0.218212820950704 0.409847238986744 0.730160208643815 0.5625 27.3 27 3 increased pancreatic beta cell number 0.218212820950704 0.409847238986744 0.730160208643815 0.5625 27.3 27 3 abnormal molar crown morphology 0.218212820950704 0.409847238986744 0.730160208643815 0.5625 27.3 27 3 abnormal feces composition 0.14520614429186 0.326730243261874 0.726915052160954 0.56 27.3 27 3 decreased acute inflammation 0.14520614429186 0.326730243261874 0.726915052160954 0.56 27.3 27 3 impaired conditioned place preference behavior 0.14520614429186 0.326730243261874 0.726915052160954 0.56 27.3 27 3 increased liver glycogen level 0.14520614429186 0.326730243261874 0.726915052160954 0.56 27.3 27 3 abnormal retinal photoreceptor morphology 0.100361943538064 0.249995768557768 0.725387919698431 0.558823529411765 27.3 27 3 abnormal bone remodeling 0.100361943538064 0.249995768557768 0.725387919698431 0.558823529411765 27.3 27 3 decreased pancreatic beta cell number 0.100361943538064 0.249995768557768 0.725387919698431 0.558823529411765 27.3 27 3 abnormal skin physiology 0.100361943538064 0.249995768557768 0.725387919698431 0.558823529411765 27.3 27 3 increased neutrophil cell number 0.00182445404367769 0.0120434953956279 0.725124620997996 0.558620689655172 27.3 27 3 decreased IgG level 0.00588355888936506 0.0312054429366644 0.72504397094561 0.558558558558559 27.3 27 3 abnormal NK cell physiology 0.0366360078842834 0.123401583767305 0.723510297818279 0.557377049180328 27.3 27 3 thick epidermis 0.0266618643343328 0.100259089239082 0.723206301894826 0.557142857142857 27.3 27 3 decreased bone ossification 0.142852554641623 0.324102223064044 0.721145885080311 0.555555555555556 27.3 27 3 cortical renal glomerulopathies 0.213211242606307 0.409847238986744 0.721145885080311 0.555555555555556 27.3 27 3 abnormal radius morphology 0.213211242606307 0.409847238986744 0.721145885080311 0.555555555555556 27.3 27 3 abnormal Peyer's patch follicle morphology 0.213211242606307 0.409847238986744 0.721145885080311 0.555555555555556 27.3 27 3 acidosis 0.213211242606307 0.409847238986744 0.721145885080311 0.555555555555556 27.3 27 3 abnormal glycogen homeostasis 0.213211242606307 0.409847238986744 0.721145885080311 0.555555555555556 27.3 27 3 crypts of Lieberkuhn abscesses 0.343914473353078 0.571657527270063 0.721145885080311 0.555555555555556 27.3 27 3 absent parathyroid glands 0.343914473353078 0.571657527270063 0.721145885080311 0.555555555555556 27.3 27 3 abnormal cholinergic neuron morphology 0.343914473353078 0.571657527270063 0.721145885080311 0.555555555555556 27.3 27 3 dilated uterus 0.343914473353078 0.571657527270063 0.721145885080311 0.555555555555556 27.3 27 3 multifocal hepatic necrosis 0.343914473353078 0.571657527270063 0.721145885080311 0.555555555555556 27.3 27 3 abnormal laryngeal cartilage morphology 0.343914473353078 0.571657527270063 0.721145885080311 0.555555555555556 27.3 27 3 abnormal lens capsule morphology 0.343914473353078 0.571657527270063 0.721145885080311 0.555555555555556 27.3 27 3 abnormal abdominal wall morphology 0.343914473353078 0.571657527270063 0.721145885080311 0.555555555555556 27.3 27 3 biliary cyst 0.343914473353078 0.571657527270063 0.721145885080311 0.555555555555556 27.3 27 3 abnormal artery development 0.343914473353078 0.571657527270063 0.721145885080311 0.555555555555556 27.3 27 3 decreased muscle weight 0.343914473353078 0.571657527270063 0.721145885080311 0.555555555555556 27.3 27 3 abnormal hair cell mechanoelectric transduction 0.343914473353078 0.571657527270063 0.721145885080311 0.555555555555556 27.3 27 3 abnormal intervertebral disk development 0.343914473353078 0.571657527270063 0.721145885080311 0.555555555555556 27.3 27 3 hemothorax 0.343914473353078 0.571657527270063 0.721145885080311 0.555555555555556 27.3 27 3 abnormal oxygen consumption 0.343914473353078 0.571657527270063 0.721145885080311 0.555555555555556 27.3 27 3 increased tidal volume 0.343914473353078 0.571657527270063 0.721145885080311 0.555555555555556 27.3 27 3 axonal spheroids 0.343914473353078 0.571657527270063 0.721145885080311 0.555555555555556 27.3 27 3 abnormal pulmonary alveolar system morphology 0.343914473353078 0.571657527270063 0.721145885080311 0.555555555555556 27.3 27 3 decreased pancreatic beta cell proliferation 0.343914473353078 0.571657527270063 0.721145885080311 0.555555555555556 27.3 27 3 abnormal trabecular bone morphology 0.00572119279048753 0.0309379718833429 0.71993387518942 0.554621848739496 27.3 27 3 abnormal T-helper 1 physiology 0.0691982393766757 0.203464090365817 0.718077179186353 0.553191489361702 27.3 27 3 abnormal humoral immune response 0.0102325420023677 0.0477550623468848 0.717025051451281 0.552380952380952 27.3 27 3 abnormal cytokine secretion 0.00229147638850674 0.0147669624777475 0.716463119592777 0.551948051948052 27.3 27 3 dermatitis 0.0490674934080694 0.156193922281023 0.716172465183206 0.551724137931034 27.3 27 3 enlarged epididymis 0.140376677306779 0.320649205510205 0.716172465183206 0.551724137931034 27.3 27 3 hyperkeratosis 0.0351514390414823 0.120907692443798 0.714875051297004 0.550724637681159 27.3 27 3 decreased skin tensile strength 0.208131581480836 0.407018324633317 0.713934426229508 0.55 27.3 27 3 nuclear cataracts 0.208131581480836 0.407018324633317 0.713934426229508 0.55 27.3 27 3 autoimmune response 0.137820216856973 0.315099071168862 0.711840776885727 0.548387096774194 27.3 27 3 increased inflammatory response 0.0180060193501732 0.0717213340809542 0.710518472037023 0.547368421052632 27.3 27 3 abnormal gametogenesis 0.0931440505147607 0.234509944995412 0.708034141715215 0.545454545454545 27.3 27 3 decreased systemic arterial blood pressure 0.135214369276089 0.309425707060048 0.708034141715215 0.545454545454545 27.3 27 3 abnormal T cell subpopulation ratio 0.135214369276089 0.309425707060048 0.708034141715215 0.545454545454545 27.3 27 3 abnormal female reproductive system physiology 0.20305425532922 0.397401620874458 0.708034141715215 0.545454545454545 27.3 27 3 impaired humoral immune response 0.20305425532922 0.397401620874458 0.708034141715215 0.545454545454545 27.3 27 3 abnormal awl hair morphology 0.329246871972109 0.56974023932565 0.708034141715215 0.545454545454545 27.3 27 3 social withdrawal 0.329246871972109 0.56974023932565 0.708034141715215 0.545454545454545 27.3 27 3 abnormal hemoglobin 0.329246871972109 0.56974023932565 0.708034141715215 0.545454545454545 27.3 27 3 focal hepatic necrosis 0.329246871972109 0.56974023932565 0.708034141715215 0.545454545454545 27.3 27 3 variable body spotting 0.329246871972109 0.56974023932565 0.708034141715215 0.545454545454545 27.3 27 3 patent ductus arteriosus 0.329246871972109 0.56974023932565 0.708034141715215 0.545454545454545 27.3 27 3 allodynia 0.329246871972109 0.56974023932565 0.708034141715215 0.545454545454545 27.3 27 3 loss of cortex neurons 0.329246871972109 0.56974023932565 0.708034141715215 0.545454545454545 27.3 27 3 abnormal nerve fiber response 0.329246871972109 0.56974023932565 0.708034141715215 0.545454545454545 27.3 27 3 pulmonary hypertension 0.329246871972109 0.56974023932565 0.708034141715215 0.545454545454545 27.3 27 3 abnormal hair medulla 0.329246871972109 0.56974023932565 0.708034141715215 0.545454545454545 27.3 27 3 abnormal platelet aggregation 0.329246871972109 0.56974023932565 0.708034141715215 0.545454545454545 27.3 27 3 enhanced behavioral response to addictive substance 0.329246871972109 0.56974023932565 0.708034141715215 0.545454545454545 27.3 27 3 abnormal extraembryonic ectoderm morphology 0.329246871972109 0.56974023932565 0.708034141715215 0.545454545454545 27.3 27 3 impaired fertilization 0.0452328090062221 0.145558360159091 0.70466255056419 0.542857142857143 27.3 27 3 dehydration 0.0452328090062221 0.145558360159091 0.70466255056419 0.542857142857143 27.3 27 3 increased susceptibility to bacterial infection induced morbidity/mortality 0.0445588716729768 0.143575379904831 0.703117237953303 0.541666666666667 27.3 27 3 abnormal osteoclast morphology 0.0899968008923918 0.2291371977685 0.703117237953303 0.541666666666667 27.3 27 3 abnormal vasodilation 0.198028881094888 0.388024294386399 0.703117237953303 0.541666666666667 27.3 27 3 abnormal mast cell morphology 0.316026718642246 0.55050172452562 0.698956780923994 0.538461538461538 27.3 27 3 abnormal dopaminergic neuron morphology 0.316026718642246 0.55050172452562 0.698956780923994 0.538461538461538 27.3 27 3 decreased alcohol consumption 0.316026718642246 0.55050172452562 0.698956780923994 0.538461538461538 27.3 27 3 abnormal vestibulocochlear ganglion morphology 0.316026718642246 0.55050172452562 0.698956780923994 0.538461538461538 27.3 27 3 vestibular hair cell degeneration 0.316026718642246 0.55050172452562 0.698956780923994 0.538461538461538 27.3 27 3 empty decidua capsularis 0.316026718642246 0.55050172452562 0.698956780923994 0.538461538461538 27.3 27 3 acanthosis 0.127309379625915 0.29763353554461 0.698956780923994 0.538461538461538 27.3 27 3 abnormal lens fiber morphology 0.127309379625915 0.29763353554461 0.698956780923994 0.538461538461538 27.3 27 3 abnormal leukocyte adhesion 0.127309379625915 0.29763353554461 0.698956780923994 0.538461538461538 27.3 27 3 increased autoantibody level 0.127309379625915 0.29763353554461 0.698956780923994 0.538461538461538 27.3 27 3 abnormal response to injury 0.127309379625915 0.29763353554461 0.698956780923994 0.538461538461538 27.3 27 3 abnormal spleen germinal center morphology 0.18824542468806 0.371306277914289 0.695390674898872 0.535714285714286 27.3 27 3 abnormal heart tube morphology 0.183517663358916 0.371306277914289 0.692300049677099 0.533333333333333 27.3 27 3 abnormal estrous cycle 0.183517663358916 0.371306277914289 0.692300049677099 0.533333333333333 27.3 27 3 abnormal pain threshold 0.183517663358916 0.371306277914289 0.692300049677099 0.533333333333333 27.3 27 3 abnormal spleen marginal zone morphology 0.183517663358916 0.371306277914289 0.692300049677099 0.533333333333333 27.3 27 3 decreased chondrocyte number 0.303956451323944 0.530963253278308 0.692300049677099 0.533333333333333 27.3 27 3 decreased salivation 0.303956451323944 0.530963253278308 0.692300049677099 0.533333333333333 27.3 27 3 abnormal apical ectodermal ridge morphology 0.303956451323944 0.530963253278308 0.692300049677099 0.533333333333333 27.3 27 3 altered righting response 0.303956451323944 0.530963253278308 0.692300049677099 0.533333333333333 27.3 27 3 arthritis 0.303956451323944 0.530963253278308 0.692300049677099 0.533333333333333 27.3 27 3 obese 0.054320242965413 0.170071245281894 0.691176185960091 0.532467532467532 27.3 27 3 abnormal immune system physiology 0.0184867842176636 0.0735774011863011 0.690904283447911 0.532258064516129 27.3 27 3 decreased urine osmolality 0.114521094653935 0.273822776094143 0.688767906566501 0.530612244897959 27.3 27 3 decreased susceptibility to injury 0.0744762150759844 0.210361753377574 0.687209608135355 0.529411764705882 27.3 27 3 decreased regulatory T cell number 0.174423348231368 0.371306277914289 0.687209608135355 0.529411764705882 27.3 27 3 increased susceptibility to viral infection induced morbidity/mortality 0.174423348231368 0.371306277914289 0.687209608135355 0.529411764705882 27.3 27 3 hydroureter 0.292830110235049 0.512787679837863 0.687209608135355 0.529411764705882 27.3 27 3 abnormal urinary bladder morphology 0.292830110235049 0.512787679837863 0.687209608135355 0.529411764705882 27.3 27 3 increased regulatory T cell number 0.292830110235049 0.512787679837863 0.687209608135355 0.529411764705882 27.3 27 3 abnormal tendon morphology 0.292830110235049 0.512787679837863 0.687209608135355 0.529411764705882 27.3 27 3 abnormal circulating chemokine level 0.292830110235049 0.512787679837863 0.687209608135355 0.529411764705882 27.3 27 3 abnormal T cell activation 0.0701590924189002 0.205560356174339 0.684114069359971 0.527027027027027 27.3 27 3 decreased susceptibility to induced arthritis 0.104999190700651 0.255438128966131 0.683190838497137 0.526315789473684 27.3 27 3 abnormal compact bone morphology 0.165819989461203 0.362139792611715 0.683190838497137 0.526315789473684 27.3 27 3 abnormal ear morphology 0.282497926622518 0.49574151144516 0.683190838497137 0.526315789473684 27.3 27 3 abnormal response to novelty 0.282497926622518 0.49574151144516 0.683190838497137 0.526315789473684 27.3 27 3 increased B cell proliferation 0.102732297052148 0.253499228611033 0.682032887923413 0.525423728813559 27.3 27 3 abnormal hematopoietic system physiology 0.272846796413003 0.479312433670442 0.679937548790008 0.523809523809524 27.3 27 3 abnormal immune system morphology 0.150036809267254 0.332473789392572 0.677250048597162 0.521739130434783 27.3 27 3 delayed wound healing 0.150036809267254 0.332473789392572 0.677250048597162 0.521739130434783 27.3 27 3 increased percent body fat/body weight 0.13935176078054 0.318454299441061 0.673994038748137 0.519230769230769 27.3 27 3 polyphagia 0.135991822426138 0.311061754744845 0.673069492741624 0.518518518518518 27.3 27 3 decreased granulocyte number 0.239533368310862 0.421534668322086 0.671411686109255 0.517241379310345 27.3 27 3 increased susceptibility to induced arthritis 0.239533368310862 0.421534668322086 0.671411686109255 0.517241379310345 27.3 27 3 abnormal CD8-positive, alpha beta T cell morphology 0.232261606294323 0.409847238986744 0.669967790010096 0.516129032258065 27.3 27 3 abnormal T cell proliferation 0.232261606294323 0.409847238986744 0.669967790010096 0.516129032258065 27.3 27 3 abnormal epidermis stratum basale morphology 0.225335190284793 0.409847238986744 0.668698911619925 0.515151515151515 27.3 27 3 decreased inflammatory response 0.095419391998189 0.24011708406221 0.664484422681144 0.511904761904762 27.3 27 3 abnormal intestinal mucosa morphology 0.194992539483571 0.382225328577922 0.664125047655357 0.511627906976744 27.3 27 3 hepatic necrosis 0.184500207411024 0.371306277914289 0.662840473095095 0.51063829787234 27.3 27 3 abnormal epidermis stratum corneum morphology 0.179547763516907 0.371306277914289 0.662276833237021 0.510204081632653 27.3 27 3 decreased monocyte cell number 0.145670740943638 0.327627457592495 0.659016393442623 0.507692307692308 27.3 27 3 abnormal stomach morphology 0.317420747762454 0.552156720321051 0.64903129657228 0.5 27.3 27 3 small seminal vesicle 0.317420747762454 0.552156720321051 0.64903129657228 0.5 27.3 27 3 abnormal tectorial membrane morphology 0.317420747762454 0.552156720321051 0.64903129657228 0.5 27.3 27 3 decreased Peyer's patch number 0.317420747762454 0.552156720321051 0.64903129657228 0.5 27.3 27 3 abnormal intestinal epithelium morphology 0.222629523174004 0.409847238986744 0.64903129657228 0.5 27.3 27 3 impaired ovarian folliculogenesis 0.251014922546599 0.441583889557755 0.64903129657228 0.5 27.3 27 3 abnormal systemic arterial blood pressure 0.267389927188913 0.469892224572534 0.64903129657228 0.5 27.3 27 3 abnormal epidermis stratum granulosum morphology 0.267389927188913 0.469892224572534 0.64903129657228 0.5 27.3 27 3 decreased osteoblast cell number 0.276247032338218 0.485114361412861 0.64903129657228 0.5 27.3 27 3 abnormal crypts of Lieberkuhn morphology 0.285613899793185 0.501032846075845 0.64903129657228 0.5 27.3 27 3 arrested T cell differentiation 0.295549073262806 0.517184889019508 0.64903129657228 0.5 27.3 27 3 salivary gland inflammation 0.295549073262806 0.517184889019508 0.64903129657228 0.5 27.3 27 3 decreased circulating progesterone level 0.306122841086112 0.53455989273549 0.64903129657228 0.5 27.3 27 3 decreased ovulation rate 0.32954854272819 0.570063977772164 0.64903129657228 0.5 27.3 27 3 abnormal adipose tissue distribution 0.431138199181733 0.571657527270063 0.64903129657228 0.5 27.3 27 3 waved hair 0.356864271764201 0.571657527270063 0.64903129657228 0.5 27.3 27 3 abnormal stomach glandular epithelium morphology 0.372448977863791 0.571657527270063 0.64903129657228 0.5 27.3 27 3 decreased digestive secretion 0.431138199181733 0.571657527270063 0.64903129657228 0.5 27.3 27 3 amyloidosis 0.431138199181733 0.571657527270063 0.64903129657228 0.5 27.3 27 3 thick dermal layer 0.372448977863791 0.571657527270063 0.64903129657228 0.5 27.3 27 3 abnormal pilomotor reflex 0.431138199181733 0.571657527270063 0.64903129657228 0.5 27.3 27 3 absent visceral yolk sac blood islands 0.409050074270335 0.571657527270063 0.64903129657228 0.5 27.3 27 3 abnormal antigen presentation 0.409050074270335 0.571657527270063 0.64903129657228 0.5 27.3 27 3 increased litter size 0.431138199181733 0.571657527270063 0.64903129657228 0.5 27.3 27 3 abnormal spleen periarteriolar lymphoid sheath morphology 0.409050074270335 0.571657527270063 0.64903129657228 0.5 27.3 27 3 abnormal Peyer's patch T cell area morphology 0.356864271764201 0.571657527270063 0.64903129657228 0.5 27.3 27 3 increased urine phosphate level 0.431138199181733 0.571657527270063 0.64903129657228 0.5 27.3 27 3 abnormal kidney medulla morphology 0.409050074270335 0.571657527270063 0.64903129657228 0.5 27.3 27 3 absent tail 0.431138199181733 0.571657527270063 0.64903129657228 0.5 27.3 27 3 abnormal uterus development 0.409050074270335 0.571657527270063 0.64903129657228 0.5 27.3 27 3 abnormal decidualization 0.409050074270335 0.571657527270063 0.64903129657228 0.5 27.3 27 3 abnormal thymocyte activation 0.356864271764201 0.571657527270063 0.64903129657228 0.5 27.3 27 3 skeletal muscle necrosis 0.409050074270335 0.571657527270063 0.64903129657228 0.5 27.3 27 3 increased hepatocyte proliferation 0.431138199181733 0.571657527270063 0.64903129657228 0.5 27.3 27 3 decreased heart rate variability 0.372448977863791 0.571657527270063 0.64903129657228 0.5 27.3 27 3 absent cochlear hair cells 0.431138199181733 0.571657527270063 0.64903129657228 0.5 27.3 27 3 abnormal epididymis epithelium morphology 0.389700081697185 0.571657527270063 0.64903129657228 0.5 27.3 27 3 sepsis 0.389700081697185 0.571657527270063 0.64903129657228 0.5 27.3 27 3 premature hair loss 0.409050074270335 0.571657527270063 0.64903129657228 0.5 27.3 27 3 decreased circulating prolactin level 0.389700081697185 0.571657527270063 0.64903129657228 0.5 27.3 27 3 abnormal B cell proliferation 0.431138199181733 0.571657527270063 0.64903129657228 0.5 27.3 27 3 increased susceptibility to autoimmune disorder 0.372448977863791 0.571657527270063 0.64903129657228 0.5 27.3 27 3 hemoperitoneum 0.431138199181733 0.571657527270063 0.64903129657228 0.5 27.3 27 3 decreased renal glomerular filtration rate 0.431138199181733 0.571657527270063 0.64903129657228 0.5 27.3 27 3 abnormal behavioral response to addictive substance 0.431138199181733 0.571657527270063 0.64903129657228 0.5 27.3 27 3 abnormal renal reabsorbtion 0.409050074270335 0.571657527270063 0.64903129657228 0.5 27.3 27 3 decreased skeletal muscle weight 0.389700081697185 0.571657527270063 0.64903129657228 0.5 27.3 27 3 decreased compact bone area 0.409050074270335 0.571657527270063 0.64903129657228 0.5 27.3 27 3 abnormal respiratory motile cilium morphology 0.431138199181733 0.571657527270063 0.64903129657228 0.5 27.3 27 3 decreased response to antigen 0.409050074270335 0.571657527270063 0.64903129657228 0.5 27.3 27 3 absent trophoblast giant cells 0.45696834454266 0.597953054734281 0.64903129657228 0.5 27.3 27 3 decreased incidence of induced tumors 0.45696834454266 0.597953054734281 0.64903129657228 0.5 27.3 27 3 abnormal gland morphology 0.45696834454266 0.597953054734281 0.64903129657228 0.5 27.3 27 3 intestinal hypoperistalsis 0.45696834454266 0.597953054734281 0.64903129657228 0.5 27.3 27 3 cochlear ganglion hypoplasia 0.45696834454266 0.597953054734281 0.64903129657228 0.5 27.3 27 3 abnormal submandibular gland morphology 0.45696834454266 0.597953054734281 0.64903129657228 0.5 27.3 27 3 increased left ventricle diastolic pressure 0.45696834454266 0.597953054734281 0.64903129657228 0.5 27.3 27 3 increased susceptibility to atherosclerosis 0.45696834454266 0.597953054734281 0.64903129657228 0.5 27.3 27 3 absent inguinal lymph nodes 0.45696834454266 0.597953054734281 0.64903129657228 0.5 27.3 27 3 increased T-helper 17 cell number 0.45696834454266 0.597953054734281 0.64903129657228 0.5 27.3 27 3 common ventricle 0.45696834454266 0.597953054734281 0.64903129657228 0.5 27.3 27 3 abnormal food intake 0.19882317002871 0.389427272005052 0.63962504589732 0.492753623188406 27.3 27 3 abnormal thrombosis 0.256198045948386 0.450542693034013 0.636305192717922 0.490196078431373 27.3 27 3 focal hair loss 0.368273015676347 0.571657527270063 0.626650907035305 0.482758620689655 27.3 27 3 abnormal digestive system physiology 0.308021385194862 0.537686453103312 0.623070044709389 0.48 27.3 27 3 abnormal hair shaft morphology 0.317687544921618 0.552427660253425 0.621988325881768 0.479166666666667 27.3 27 3 pancreas inflammation 0.414919077616596 0.571657527270063 0.620812544547398 0.478260869565217 27.3 27 3 dry skin 0.433243794810746 0.571657527270063 0.618125044354553 0.476190476190476 27.3 27 3 decreased circulating magnesium level 0.453404923980938 0.595011737484877 0.614871754647423 0.473684210526316 27.3 27 3 decreased liver glycogen level 0.453404923980938 0.595011737484877 0.614871754647423 0.473684210526316 27.3 27 3 decreased cytotoxic T cell cytolysis 0.401102154434742 0.571657527270063 0.610852985009205 0.470588235294118 27.3 27 3 polydipsia 0.415999168033326 0.571657527270063 0.608466840536513 0.46875 27.3 27 3 increased systemic arterial blood pressure 0.376823517516362 0.571657527270063 0.607603767003837 0.468085106382979 27.3 27 3 gastrointestinal hemorrhage 0.431906465288195 0.571657527270063 0.605762543467462 0.466666666666667 27.3 27 3 vagina atresia 0.501006994348425 0.650106884946118 0.605762543467462 0.466666666666667 27.3 27 3 abnormal energy homeostasis 0.501006994348425 0.650106884946118 0.605762543467462 0.466666666666667 27.3 27 3 lactation failure 0.501006994348425 0.650106884946118 0.605762543467462 0.466666666666667 27.3 27 3 impaired macrophage phagocytosis 0.401846812282141 0.571657527270063 0.603750043323051 0.465116279069767 27.3 27 3 increased circulating luteinizing hormone level 0.448955732665921 0.5894839720277 0.602671918245689 0.464285714285714 27.3 27 3 increased tumor growth/size 0.415338536634033 0.571657527270063 0.601541201701138 0.463414634146341 27.3 27 3 decreased IgA level 0.401484554192441 0.571657527270063 0.599105812220566 0.461538461538462 27.3 27 3 tight skin 0.529805182501294 0.677230416994845 0.599105812220566 0.461538461538462 27.3 27 3 abnormal digestion 0.529805182501294 0.677230416994845 0.599105812220566 0.461538461538462 27.3 27 3 increased circulating adrenocorticotropin level 0.529805182501294 0.677230416994845 0.599105812220566 0.461538461538462 27.3 27 3 dystrophic cardiac calcinosis 0.529805182501294 0.677230416994845 0.599105812220566 0.461538461538462 27.3 27 3 abnormal bile duct development 0.529805182501294 0.677230416994845 0.599105812220566 0.461538461538462 27.3 27 3 decreased follicle stimulating hormone level 0.529805182501294 0.677230416994845 0.599105812220566 0.461538461538462 27.3 27 3 increased circulating ammonia level 0.529805182501294 0.677230416994845 0.599105812220566 0.461538461538462 27.3 27 3 abnormal hair follicle inner root sheath morphology 0.529805182501294 0.677230416994845 0.599105812220566 0.461538461538462 27.3 27 3 impaired natural killer cell mediated cytotoxicity 0.42404033727128 0.571657527270063 0.592098726697519 0.456140350877193 27.3 27 3 absent vibrissae 0.477376139011175 0.624492845537889 0.590028451429346 0.454545454545455 27.3 27 3 abnormal large intestine morphology 0.563402905018119 0.718884188885648 0.590028451429346 0.454545454545455 27.3 27 3 rectal hemorrhage 0.563402905018119 0.718884188885648 0.590028451429346 0.454545454545455 27.3 27 3 pathological neovascularization 0.563402905018119 0.718884188885648 0.590028451429346 0.454545454545455 27.3 27 3 decreased palatine bone horizontal plate size 0.563402905018119 0.718884188885648 0.590028451429346 0.454545454545455 27.3 27 3 increased eosinophil cell number 0.444803760532668 0.584186565113523 0.586221816258834 0.451612903225806 27.3 27 3 abnormal intestine physiology 0.495339140840788 0.64325560576427 0.586221816258834 0.451612903225806 27.3 27 3 abnormal heart electrocardiography waveform feature 0.532392730340086 0.68036317324478 0.584128166915052 0.45 27.3 27 3 decreased retinal photoreceptor cell number 0.514510440219949 0.667280875936978 0.581890127961355 0.448275862068966 27.3 27 3 increased double-positive T cell number 0.514510440219949 0.667280875936978 0.581890127961355 0.448275862068966 27.3 27 3 wrinkled skin 0.535039698467425 0.683570236228927 0.576916708064249 0.444444444444444 27.3 27 3 abnormal iron level 0.558492919103316 0.713351032744287 0.576916708064249 0.444444444444444 27.3 27 3 abnormal intestinal absorption 0.587579037521612 0.732449439155605 0.567902384500745 0.4375 27.3 27 3 large intestinal inflammation 0.587579037521612 0.732449439155605 0.567902384500745 0.4375 27.3 27 3 abnormal wound healing 0.587579037521612 0.732449439155605 0.567902384500745 0.4375 27.3 27 3 increased vasoconstriction 0.606754431987091 0.752956672271334 0.556312539919097 0.428571428571429 27.3 27 3 increased keratinocyte proliferation 0.606754431987091 0.752956672271334 0.556312539919097 0.428571428571429 27.3 27 3 increased bone ossification 0.606754431987091 0.752956672271334 0.556312539919097 0.428571428571429 27.3 27 3 abnormal vasoconstriction 0.620371513674513 0.768513018060434 0.556312539919097 0.428571428571429 27.3 27 3 absent atrioventricular cushions 0.620371513674513 0.768513018060434 0.556312539919097 0.428571428571429 27.3 27 3 abnormal olfactory system physiology 0.620371513674513 0.768513018060434 0.556312539919097 0.428571428571429 27.3 27 3 decreased coping response 0.620371513674513 0.768513018060434 0.556312539919097 0.428571428571429 27.3 27 3 enlarged stomach 0.620371513674513 0.768513018060434 0.556312539919097 0.428571428571429 27.3 27 3 abnormal glucose tolerance 0.620371513674513 0.768513018060434 0.556312539919097 0.428571428571429 27.3 27 3 abnormal respiratory motile cilium physiology 0.620371513674513 0.768513018060434 0.556312539919097 0.428571428571429 27.3 27 3 abnormal leukocyte cell number 0.622958052440371 0.771525096064438 0.549180327868853 0.423076923076923 27.3 27 3 increased susceptibility to parasitic infection 0.636760775179597 0.788227135237247 0.548070872661036 0.422222222222222 27.3 27 3 altered susceptibility to infection 0.634920551919592 0.786144784917863 0.54655267079771 0.421052631578947 27.3 27 3 impaired sperm capacitation 0.657877694901252 0.793193651246757 0.540859413810234 0.416666666666667 27.3 27 3 abnormal anogenital distance 0.657877694901252 0.793193651246757 0.540859413810234 0.416666666666667 27.3 27 3 decreased oligodendrocyte number 0.657877694901252 0.793193651246757 0.540859413810234 0.416666666666667 27.3 27 3 stomach inflammation 0.659667778182275 0.793193651246757 0.537129348887404 0.413793103448276 27.3 27 3 distended urinary bladder 0.665819657688937 0.793193651246757 0.534496361883054 0.411764705882353 27.3 27 3 enlarged sebaceous gland 0.665819657688937 0.793193651246757 0.534496361883054 0.411764705882353 27.3 27 3 cryptorchism 0.683401920796773 0.795862489691934 0.528840315725562 0.407407407407407 27.3 27 3 increased airway responsiveness 0.699947859891905 0.814749790117508 0.519225037257824 0.4 27.3 27 3 greasy coat 0.699947859891905 0.814749790117508 0.519225037257824 0.4 27.3 27 3 increased urine calcium level 0.703272432972597 0.817090227472833 0.519225037257824 0.4 27.3 27 3 abnormal regulatory T cell physiology 0.734829619483501 0.844485413936341 0.507937536447871 0.391304347826087 27.3 27 3 abnormal sperm axoneme morphology 0.734118491334332 0.843863099442769 0.504802119556218 0.388888888888889 27.3 27 3 decreased susceptibility to bacterial infection induced morbidity/mortality 0.76307417976087 0.873916676867019 0.502475842507572 0.387096774193548 27.3 27 3 abnormal bile salt homeostasis 0.762668125886754 0.873652757606862 0.494500035483642 0.380952380952381 27.3 27 3 abnormal intestinal lipid absorption 0.767369153314081 0.878431094739427 0.48677347242921 0.375 27.3 27 3 abnormal urinary bladder physiology 0.767369153314081 0.878431094739427 0.48677347242921 0.375 27.3 27 3 shiny skin 0.791983955992931 0.905774754267778 0.478233586947996 0.368421052631579 27.3 27 3 increased activated T cell number 0.812989695819202 0.913635746603022 0.472022761143476 0.363636363636364 27.3 27 3 decreased airway responsiveness 0.812989695819202 0.913635746603022 0.472022761143476 0.363636363636364 27.3 27 3 diarrhea 0.842477503972701 0.935981594967438 0.472022761143476 0.363636363636364 27.3 27 3 abnormal stomach mucosa morphology 0.831176055610624 0.924458054250582 0.467302533532042 0.36 27.3 27 3 abnormal hair cuticle 0.80322940486051 0.913635746603022 0.463593783265914 0.357142857142857 27.3 27 3 abnormal iris pigmentation 0.80322940486051 0.913635746603022 0.463593783265914 0.357142857142857 27.3 27 3 abnormal body temperature homeostasis 0.86112815770515 0.956061723852516 0.460602855631941 0.354838709677419 27.3 27 3 thin skin 0.873592443782319 0.969683714372387 0.458139738756904 0.352941176470588 27.3 27 3 abnormal circulating cytokine level 0.839751699157727 0.933787372219421 0.454321907600596 0.35 27.3 27 3 abnormal epidermis stratum spinosum morphology 0.854870177344813 0.949325699171974 0.432687531048187 0.333333333333333 27.3 27 3 joint inflammation 0.854870177344813 0.949325699171974 0.432687531048187 0.333333333333333 27.3 27 3 intestinal ulcer 0.908768587781084 0.996720397753724 0.413019916000542 0.318181818181818 27.3 27 3 increased circulating estradiol level 0.894643370086055 0.985364666202087 0.405644560357675 0.3125 27.3 27 3 abnormal pancreatic alpha cell morphology 0.894643370086055 0.985364666202087 0.405644560357675 0.3125 27.3 27 3 increased susceptibility to fungal infection 0.93243450186941 1 0.395062528348344 0.304347826086957 27.3 27 3 nephrocalcinosis 0.924594862917148 1 0.381783115630753 0.294117647058824 27.3 27 3 decreased susceptibility to parasitic infection 0.975763555468673 1 0.365080104321908 0.28125 27.3 27 3 abnormal contextual conditioning behavior 2.41126135670989e-13 9.26616115517972e-12 0.69501349055661 1 27.2 27 2 impaired synaptic plasticity 1.59630778727716e-08 2.90902243285857e-07 0.69501349055661 1 27.2 27 2 abnormal Mullerian duct morphology 1.09295984252126e-06 1.39422441449827e-05 0.69501349055661 1 27.2 27 2 increased thymocyte apoptosis 1.09295984252126e-06 1.39422441449827e-05 0.69501349055661 1 27.2 27 2 abnormal nest building behavior 1.85353172753155e-06 2.23276521657856e-05 0.69501349055661 1 27.2 27 2 diaphragmatic hernia 1.85353172753155e-06 2.23276521657856e-05 0.69501349055661 1 27.2 27 2 abnormal long term depression 4.40745361406347e-05 0.000378053133275271 0.69501349055661 1 27.2 27 2 increased liver adenoma incidence 4.40745361406347e-05 0.000378053133275271 0.69501349055661 1 27.2 27 2 abnormal sternebra morphology 4.40745361406347e-05 0.000378053133275271 0.69501349055661 1 27.2 27 2 abnormal cochlear inner hair cell morphology 4.40745361406347e-05 0.000378053133275271 0.69501349055661 1 27.2 27 2 abnormal interatrial septum morphology 0.00012672015619653 0.000988139149024669 0.69501349055661 1 27.2 27 2 abnormal dorsal-ventral axis patterning 0.00012672015619653 0.000988139149024669 0.69501349055661 1 27.2 27 2 abnormal involuntary movement 0.00012672015619653 0.000988139149024669 0.69501349055661 1 27.2 27 2 coloboma 0.00012672015619653 0.000988139149024669 0.69501349055661 1 27.2 27 2 intraventricular hemorrhage 0.000214862839099508 0.00154695025256158 0.69501349055661 1 27.2 27 2 impaired muscle relaxation 0.000214862839099508 0.00154695025256158 0.69501349055661 1 27.2 27 2 increased cochlear outer hair cell number 0.000214862839099508 0.00154695025256158 0.69501349055661 1 27.2 27 2 dystonia 0.000214862839099508 0.00154695025256158 0.69501349055661 1 27.2 27 2 kidney degeneration 0.000214862839099508 0.00154695025256158 0.69501349055661 1 27.2 27 2 impaired somite development 0.000214862839099508 0.00154695025256158 0.69501349055661 1 27.2 27 2 absent teeth 0.00104726042691615 0.00612955367518568 0.69501349055661 1 27.2 27 2 excessive scratching 0.00104726042691615 0.00612955367518568 0.69501349055661 1 27.2 27 2 abnormal grip strength 0.00104726042691615 0.00612955367518568 0.69501349055661 1 27.2 27 2 axonal dystrophy 0.00104726042691615 0.00612955367518568 0.69501349055661 1 27.2 27 2 abnormal dopaminergic neuron morphology 0.00104726042691615 0.00612955367518568 0.69501349055661 1 27.2 27 2 abnormal vestibulocochlear ganglion morphology 0.00104726042691615 0.00612955367518568 0.69501349055661 1 27.2 27 2 abnormal retinal inner plexiform layer morphology 0.00104726042691615 0.00612955367518568 0.69501349055661 1 27.2 27 2 small otic vesicle 0.00104726042691615 0.00612955367518568 0.69501349055661 1 27.2 27 2 increased cochlear inner hair cell number 0.00104726042691615 0.00612955367518568 0.69501349055661 1 27.2 27 2 small pituitary gland 0.00104726042691615 0.00612955367518568 0.69501349055661 1 27.2 27 2 increased prostaglandin level 0.00104726042691615 0.00612955367518568 0.69501349055661 1 27.2 27 2 absent hypoglossal nerve 0.00104726042691615 0.00612955367518568 0.69501349055661 1 27.2 27 2 abnormal ear pigmentation 0.0146678191424504 0.0547429859217487 0.69501349055661 1 27.2 27 2 abnormal exoccipital bone morphology 0.0146678191424504 0.0547429859217487 0.69501349055661 1 27.2 27 2 abnormal cecum morphology 0.0146678191424504 0.0547429859217487 0.69501349055661 1 27.2 27 2 abnormal vagus ganglion morphology 0.0146678191424504 0.0547429859217487 0.69501349055661 1 27.2 27 2 dry eyes 0.0146678191424504 0.0547429859217487 0.69501349055661 1 27.2 27 2 absent eyelids 0.0146678191424504 0.0547429859217487 0.69501349055661 1 27.2 27 2 abnormal hepatobiliary system morphology 0.0146678191424504 0.0547429859217487 0.69501349055661 1 27.2 27 2 head spot 0.0146678191424504 0.0547429859217487 0.69501349055661 1 27.2 27 2 short ureter 0.0146678191424504 0.0547429859217487 0.69501349055661 1 27.2 27 2 decreased aerobic running capacity 0.0146678191424504 0.0547429859217487 0.69501349055661 1 27.2 27 2 altered response to CNS ischemic injury 0.0146678191424504 0.0547429859217487 0.69501349055661 1 27.2 27 2 early eyelid opening 0.0146678191424504 0.0547429859217487 0.69501349055661 1 27.2 27 2 colon polyps 0.0146678191424504 0.0547429859217487 0.69501349055661 1 27.2 27 2 liver cysts 0.0146678191424504 0.0547429859217487 0.69501349055661 1 27.2 27 2 abnormal ovary development 0.0146678191424504 0.0547429859217487 0.69501349055661 1 27.2 27 2 abnormal eyelid aperture 0.0146678191424504 0.0547429859217487 0.69501349055661 1 27.2 27 2 elevated level of mitotic sister chromatid exchange 0.0146678191424504 0.0547429859217487 0.69501349055661 1 27.2 27 2 binucleate 0.0146678191424504 0.0547429859217487 0.69501349055661 1 27.2 27 2 tau protein deposits 0.0146678191424504 0.0547429859217487 0.69501349055661 1 27.2 27 2 abnormal extraembryonic tissue physiology 0.0146678191424504 0.0547429859217487 0.69501349055661 1 27.2 27 2 abnormal lateral ganglionic eminence morphology 0.0146678191424504 0.0547429859217487 0.69501349055661 1 27.2 27 2 abnormal kidney epithelium morphology 0.0146678191424504 0.0547429859217487 0.69501349055661 1 27.2 27 2 accumulation of giant lysosomes in kidney/renal tubule cells 0.0146678191424504 0.0547429859217487 0.69501349055661 1 27.2 27 2 abnormal NK cell morphology 0.0146678191424504 0.0547429859217487 0.69501349055661 1 27.2 27 2 abnormal choroid pigmentation 0.0146678191424504 0.0547429859217487 0.69501349055661 1 27.2 27 2 non-pigmented tail tip 0.0146678191424504 0.0547429859217487 0.69501349055661 1 27.2 27 2 abnormal somite size 0.0146678191424504 0.0547429859217487 0.69501349055661 1 27.2 27 2 abnormal vertebral body development 0.0146678191424504 0.0547429859217487 0.69501349055661 1 27.2 27 2 ocular hypertension 0.0146678191424504 0.0547429859217487 0.69501349055661 1 27.2 27 2 craniofacial phenotype 0.0146678191424504 0.0547429859217487 0.69501349055661 1 27.2 27 2 abnormal epidermal lamellar body morphology 0.0146678191424504 0.0547429859217487 0.69501349055661 1 27.2 27 2 abnormal mitotic spindle assembly checkpoint 0.0146678191424504 0.0547429859217487 0.69501349055661 1 27.2 27 2 abnormal olfactory bulb glomerular layer morphology 0.0146678191424504 0.0547429859217487 0.69501349055661 1 27.2 27 2 abnormal cerebellum deep nucleus morphology 0.0146678191424504 0.0547429859217487 0.69501349055661 1 27.2 27 2 increased caudal vertebrae number 0.0146678191424504 0.0547429859217487 0.69501349055661 1 27.2 27 2 abnormal brain ependyma morphology 0.0146678191424504 0.0547429859217487 0.69501349055661 1 27.2 27 2 abnormal circulating serum amyloid protein level 0.0146678191424504 0.0547429859217487 0.69501349055661 1 27.2 27 2 decreased quadriceps weight 0.0146678191424504 0.0547429859217487 0.69501349055661 1 27.2 27 2 pleural effusion 0.0146678191424504 0.0547429859217487 0.69501349055661 1 27.2 27 2 abnormal hepatic vein morphology 0.0146678191424504 0.0547429859217487 0.69501349055661 1 27.2 27 2 anomalous pulmonary venous connection 0.0146678191424504 0.0547429859217487 0.69501349055661 1 27.2 27 2 pulmonary artery hypoplasia 0.0146678191424504 0.0547429859217487 0.69501349055661 1 27.2 27 2 sinoatrial block 0.0146678191424504 0.0547429859217487 0.69501349055661 1 27.2 27 2 increased heart right ventricle size 0.0146678191424504 0.0547429859217487 0.69501349055661 1 27.2 27 2 delayed suture closure 0.0146678191424504 0.0547429859217487 0.69501349055661 1 27.2 27 2 abnormal visual evoked potential 0.0146678191424504 0.0547429859217487 0.69501349055661 1 27.2 27 2 abnormal anterior commissure pars posterior morphology 0.0146678191424504 0.0547429859217487 0.69501349055661 1 27.2 27 2 decreased alveolar lamellar body number 0.0146678191424504 0.0547429859217487 0.69501349055661 1 27.2 27 2 abnormal maxillary prominence morphology 0.0146678191424504 0.0547429859217487 0.69501349055661 1 27.2 27 2 abnormal foramen magnum morphology 0.0146678191424504 0.0547429859217487 0.69501349055661 1 27.2 27 2 absent ureteric bud 0.0146678191424504 0.0547429859217487 0.69501349055661 1 27.2 27 2 lethality during fetal growth through weaning, incomplete penetrance 0.0146678191424504 0.0547429859217487 0.69501349055661 1 27.2 27 2 impaired neuron differentiation 0.0146678191424504 0.0547429859217487 0.69501349055661 1 27.2 27 2 decreased cranium length 0.0146678191424504 0.0547429859217487 0.69501349055661 1 27.2 27 2 abnormal heart echocardiography feature 0.0146678191424504 0.0547429859217487 0.69501349055661 1 27.2 27 2 prolonged PQ interval 0.0146678191424504 0.0547429859217487 0.69501349055661 1 27.2 27 2 increased cornea thickness 0.0146678191424504 0.0547429859217487 0.69501349055661 1 27.2 27 2 absent hypoglossal canal 0.0146678191424504 0.0547429859217487 0.69501349055661 1 27.2 27 2 retropleural edema 0.0146678191424504 0.0547429859217487 0.69501349055661 1 27.2 27 2 abnormal umbilical vein topology 0.0146678191424504 0.0547429859217487 0.69501349055661 1 27.2 27 2 embryo cyst 0.0146678191424504 0.0547429859217487 0.69501349055661 1 27.2 27 2 decreased white adipose tissue mass 0.0146678191424504 0.0547429859217487 0.69501349055661 1 27.2 27 2 abnormal vocalization 3.27085740157183e-09 6.92447471183823e-08 0.69501349055661 1 27.2 27 2 disorganized myocardium 1.3210880567916e-07 1.99164032804188e-06 0.69501349055661 1 27.2 27 2 enhanced paired-pulse facilitation 1.3210880567916e-07 1.99164032804188e-06 0.69501349055661 1 27.2 27 2 abnormal synaptic transmission 1.3210880567916e-07 1.99164032804188e-06 0.69501349055661 1 27.2 27 2 subcutaneous edema 3.80001945370042e-07 5.30706230693209e-06 0.69501349055661 1 27.2 27 2 abnormal nursing 3.14330793213203e-06 3.58668737668735e-05 0.69501349055661 1 27.2 27 2 abnormal impulse conducting system conduction 3.14330793213203e-06 3.58668737668735e-05 0.69501349055661 1 27.2 27 2 increased hemangiosarcoma incidence 3.14330793213203e-06 3.58668737668735e-05 0.69501349055661 1 27.2 27 2 increased body temperature 3.14330793213203e-06 3.58668737668735e-05 0.69501349055661 1 27.2 27 2 abnormal Wolffian duct morphology 5.33046281862878e-06 5.74005465858835e-05 0.69501349055661 1 27.2 27 2 abnormal chondrocyte physiology 5.33046281862878e-06 5.74005465858835e-05 0.69501349055661 1 27.2 27 2 abnormal basicranium morphology 5.33046281862878e-06 5.74005465858835e-05 0.69501349055661 1 27.2 27 2 abnormal oogenesis 9.03928323715254e-06 9.21525289033481e-05 0.69501349055661 1 27.2 27 2 abnormal lysosome physiology 9.03928323715254e-06 9.21525289033481e-05 0.69501349055661 1 27.2 27 2 abnormal temporal bone morphology 9.03928323715254e-06 9.21525289033481e-05 0.69501349055661 1 27.2 27 2 abnormal associative learning 1.53283058865194e-05 0.000146088739052555 0.69501349055661 1 27.2 27 2 absent segment of posterior cerebral artery 1.53283058865194e-05 0.000146088739052555 0.69501349055661 1 27.2 27 2 abnormal basioccipital bone morphology 2.59923418413801e-05 0.000234685845119539 0.69501349055661 1 27.2 27 2 abnormal dopamine level 2.59923418413801e-05 0.000234685845119539 0.69501349055661 1 27.2 27 2 decreased paired-pulse facilitation 2.59923418413801e-05 0.000234685845119539 0.69501349055661 1 27.2 27 2 absent ductus venosus valve 2.59923418413801e-05 0.000234685845119539 0.69501349055661 1 27.2 27 2 abnormal heart shape 7.47345080208223e-05 0.000612527475129474 0.69501349055661 1 27.2 27 2 abnormal mitral valve morphology 7.47345080208223e-05 0.000612527475129474 0.69501349055661 1 27.2 27 2 delayed kidney development 7.47345080208223e-05 0.000612527475129474 0.69501349055661 1 27.2 27 2 abnormal bile duct morphology 7.47345080208223e-05 0.000612527475129474 0.69501349055661 1 27.2 27 2 darkened coat color 7.47345080208223e-05 0.000612527475129474 0.69501349055661 1 27.2 27 2 small thoracic cage 7.47345080208223e-05 0.000612527475129474 0.69501349055661 1 27.2 27 2 abnormal hypoglossal nerve topology 7.47345080208223e-05 0.000612527475129474 0.69501349055661 1 27.2 27 2 absent incisors 0.000364307415922057 0.00246589033226154 0.69501349055661 1 27.2 27 2 abnormal pup retrieval 0.000364307415922057 0.00246589033226154 0.69501349055661 1 27.2 27 2 abnormal seizure response to electrical stimulation 0.000364307415922057 0.00246589033226154 0.69501349055661 1 27.2 27 2 delayed intramembranous bone ossification 0.000364307415922057 0.00246589033226154 0.69501349055661 1 27.2 27 2 abnormal glial cell morphology 0.000364307415922057 0.00246589033226154 0.69501349055661 1 27.2 27 2 heterochrony 0.000364307415922057 0.00246589033226154 0.69501349055661 1 27.2 27 2 abnormal interparietal bone morphology 0.000617683223695846 0.00389971324604928 0.69501349055661 1 27.2 27 2 midline facial cleft 0.000617683223695846 0.00389971324604928 0.69501349055661 1 27.2 27 2 abnormal blood flow velocity 0.000617683223695846 0.00389971324604928 0.69501349055661 1 27.2 27 2 abnormal kidney blood vessel morphology 0.000617683223695846 0.00389971324604928 0.69501349055661 1 27.2 27 2 translucent skin 0.000617683223695846 0.00389971324604928 0.69501349055661 1 27.2 27 2 irregularly shaped pupil 0.000617683223695846 0.00389971324604928 0.69501349055661 1 27.2 27 2 increased aggression towards males 0.000617683223695846 0.00389971324604928 0.69501349055661 1 27.2 27 2 absent visceral yolk sac blood islands 0.000617683223695846 0.00389971324604928 0.69501349055661 1 27.2 27 2 increased hemangioma incidence 0.000617683223695846 0.00389971324604928 0.69501349055661 1 27.2 27 2 lysosomal protein accumulation 0.000617683223695846 0.00389971324604928 0.69501349055661 1 27.2 27 2 abnormal renal tubule epithelial cell primary cilium morphology 0.000617683223695846 0.00389971324604928 0.69501349055661 1 27.2 27 2 testis degeneration 0.000617683223695846 0.00389971324604928 0.69501349055661 1 27.2 27 2 multiple persisting craniopharyngeal ducts 0.000617683223695846 0.00389971324604928 0.69501349055661 1 27.2 27 2 abnormal vitelline vein topology 0.000617683223695846 0.00389971324604928 0.69501349055661 1 27.2 27 2 abnormal respiratory function 0.0017755572241566 0.00955995366902501 0.69501349055661 1 27.2 27 2 abnormal corticospinal tract morphology 0.0017755572241566 0.00955995366902501 0.69501349055661 1 27.2 27 2 abnormal AMPA-mediated synaptic currents 0.0017755572241566 0.00955995366902501 0.69501349055661 1 27.2 27 2 loss of dopaminergic neurons 0.0017755572241566 0.00955995366902501 0.69501349055661 1 27.2 27 2 dilated bile duct 0.0017755572241566 0.00955995366902501 0.69501349055661 1 27.2 27 2 absent ovary 0.0017755572241566 0.00955995366902501 0.69501349055661 1 27.2 27 2 increased osteosarcoma incidence 0.0017755572241566 0.00955995366902501 0.69501349055661 1 27.2 27 2 decreased left ventricle systolic pressure 0.0017755572241566 0.00955995366902501 0.69501349055661 1 27.2 27 2 abnormal rostral-caudal body axis extension 0.0017755572241566 0.00955995366902501 0.69501349055661 1 27.2 27 2 pale placenta 0.0017755572241566 0.00955995366902501 0.69501349055661 1 27.2 27 2 abnormal amacrine cell morphology 0.0017755572241566 0.00955995366902501 0.69501349055661 1 27.2 27 2 abnormal fatty acid level 0.0017755572241566 0.00955995366902501 0.69501349055661 1 27.2 27 2 reduced cerebellar foliation 0.0017755572241566 0.00955995366902501 0.69501349055661 1 27.2 27 2 decreased red blood cell distribution width 0.0017755572241566 0.00955995366902501 0.69501349055661 1 27.2 27 2 persistent right dorsal aorta 0.0017755572241566 0.00955995366902501 0.69501349055661 1 27.2 27 2 abnormal pulmonary valve cusp morphology 0.0017755572241566 0.00955995366902501 0.69501349055661 1 27.2 27 2 embryonic lethality between implantation and placentation, incomplete penetrance 0.0017755572241566 0.00955995366902501 0.69501349055661 1 27.2 27 2 abnormal vitelline vein connection 0.0017755572241566 0.00955995366902501 0.69501349055661 1 27.2 27 2 abnormal sphenoid bone morphology 0.0030102720663312 0.0148719995332648 0.69501349055661 1 27.2 27 2 abnormal stomach epithelium morphology 0.0030102720663312 0.0148719995332648 0.69501349055661 1 27.2 27 2 delayed hepatic development 0.0030102720663312 0.0148719995332648 0.69501349055661 1 27.2 27 2 abnormal glossopharyngeal ganglion morphology 0.0030102720663312 0.0148719995332648 0.69501349055661 1 27.2 27 2 social withdrawal 0.0030102720663312 0.0148719995332648 0.69501349055661 1 27.2 27 2 abnormal proximal-distal axis patterning 0.0030102720663312 0.0148719995332648 0.69501349055661 1 27.2 27 2 abnormal fear/anxiety-related behavior 0.0030102720663312 0.0148719995332648 0.69501349055661 1 27.2 27 2 fatigue 0.0030102720663312 0.0148719995332648 0.69501349055661 1 27.2 27 2 variable body spotting 0.0030102720663312 0.0148719995332648 0.69501349055661 1 27.2 27 2 fused joints 0.0030102720663312 0.0148719995332648 0.69501349055661 1 27.2 27 2 pharyngeal arch hypoplasia 0.0030102720663312 0.0148719995332648 0.69501349055661 1 27.2 27 2 abnormal spinal cord ventral horn morphology 0.0030102720663312 0.0148719995332648 0.69501349055661 1 27.2 27 2 increased circulating triiodothyronine level 0.0030102720663312 0.0148719995332648 0.69501349055661 1 27.2 27 2 abnormal palate development 0.0030102720663312 0.0148719995332648 0.69501349055661 1 27.2 27 2 palatal shelf hypoplasia 0.0030102720663312 0.0148719995332648 0.69501349055661 1 27.2 27 2 abnormal palatal shelf elevation 0.0030102720663312 0.0148719995332648 0.69501349055661 1 27.2 27 2 aorta dilation 0.0030102720663312 0.0148719995332648 0.69501349055661 1 27.2 27 2 abnormal brain ependyma motile cilium morphology 0.0030102720663312 0.0148719995332648 0.69501349055661 1 27.2 27 2 decreased embryonic cilium length 0.0030102720663312 0.0148719995332648 0.69501349055661 1 27.2 27 2 thin hypoglossal nerve 0.0030102720663312 0.0148719995332648 0.69501349055661 1 27.2 27 2 reduced sympathetic cervical ganglion size 0.0030102720663312 0.0148719995332648 0.69501349055661 1 27.2 27 2 abnormal lateral semicircular canal morphology 0.00510349764334914 0.0229980985286793 0.69501349055661 1 27.2 27 2 abnormal auchene hair morphology 0.00510349764334914 0.0229980985286793 0.69501349055661 1 27.2 27 2 enlarged testis 0.00510349764334914 0.0229980985286793 0.69501349055661 1 27.2 27 2 abnormal optic nerve innervation 0.00510349764334914 0.0229980985286793 0.69501349055661 1 27.2 27 2 absent trophoblast giant cells 0.00510349764334914 0.0229980985286793 0.69501349055661 1 27.2 27 2 abnormal immune cell physiology 0.00510349764334914 0.0229980985286793 0.69501349055661 1 27.2 27 2 decreased incidence of induced tumors 0.00510349764334914 0.0229980985286793 0.69501349055661 1 27.2 27 2 ketoaciduria 0.00510349764334914 0.0229980985286793 0.69501349055661 1 27.2 27 2 abnormal PNS synaptic transmission 0.00510349764334914 0.0229980985286793 0.69501349055661 1 27.2 27 2 impaired social transmission of food preference 0.00510349764334914 0.0229980985286793 0.69501349055661 1 27.2 27 2 impaired basement membrane formation 0.00510349764334914 0.0229980985286793 0.69501349055661 1 27.2 27 2 aneurysm 0.00510349764334914 0.0229980985286793 0.69501349055661 1 27.2 27 2 peritoneal inflammation 0.00510349764334914 0.0229980985286793 0.69501349055661 1 27.2 27 2 bifid ureter 0.00510349764334914 0.0229980985286793 0.69501349055661 1 27.2 27 2 increased heart rate variability 0.00510349764334914 0.0229980985286793 0.69501349055661 1 27.2 27 2 abnormal deltoid tuberosity morphology 0.00510349764334914 0.0229980985286793 0.69501349055661 1 27.2 27 2 abnormal respiratory conducting tube morphology 0.00510349764334914 0.0229980985286793 0.69501349055661 1 27.2 27 2 osteosclerosis 0.00510349764334914 0.0229980985286793 0.69501349055661 1 27.2 27 2 vascular smooth muscle hyperplasia 0.00510349764334914 0.0229980985286793 0.69501349055661 1 27.2 27 2 abnormal developmental vascular remodeling 0.00510349764334914 0.0229980985286793 0.69501349055661 1 27.2 27 2 abnormal spinal cord dorsal column morphology 0.00510349764334914 0.0229980985286793 0.69501349055661 1 27.2 27 2 ventricular premature beat 0.00510349764334914 0.0229980985286793 0.69501349055661 1 27.2 27 2 protruding tongue 0.00510349764334914 0.0229980985286793 0.69501349055661 1 27.2 27 2 decreased transitional stage T2 B cell number 0.00510349764334914 0.0229980985286793 0.69501349055661 1 27.2 27 2 abnormal hippocampus neuron morphology 0.00510349764334914 0.0229980985286793 0.69501349055661 1 27.2 27 2 abnormal cerebellar granule cell migration 0.00510349764334914 0.0229980985286793 0.69501349055661 1 27.2 27 2 acanthocytosis 0.00510349764334914 0.0229980985286793 0.69501349055661 1 27.2 27 2 common ventricle 0.00510349764334914 0.0229980985286793 0.69501349055661 1 27.2 27 2 aorta stenosis 0.00510349764334914 0.0229980985286793 0.69501349055661 1 27.2 27 2 abnormal inferior vena cava valve morphology 0.00510349764334914 0.0229980985286793 0.69501349055661 1 27.2 27 2 thin ventricle myocardium compact layer 0.00510349764334914 0.0229980985286793 0.69501349055661 1 27.2 27 2 thick aortic valve cusps 0.00510349764334914 0.0229980985286793 0.69501349055661 1 27.2 27 2 fusion of atlas and odontoid process 0.00510349764334914 0.0229980985286793 0.69501349055661 1 27.2 27 2 abnormal pulmonary interalveolar septum morphology 0.00510349764334914 0.0229980985286793 0.69501349055661 1 27.2 27 2 decreased circulating lactate level 0.00510349764334914 0.0229980985286793 0.69501349055661 1 27.2 27 2 heart hyperplasia 0.00865209310543295 0.0354571316805298 0.69501349055661 1 27.2 27 2 abnormal urinary bladder urothelium morphology 0.00865209310543295 0.0354571316805298 0.69501349055661 1 27.2 27 2 abnormal kindling response 0.00865209310543295 0.0354571316805298 0.69501349055661 1 27.2 27 2 abnormal ion homeostasis 0.00865209310543295 0.0354571316805298 0.69501349055661 1 27.2 27 2 abnormal posterior semicircular canal morphology 0.00865209310543295 0.0354571316805298 0.69501349055661 1 27.2 27 2 polycythemia 0.00865209310543295 0.0354571316805298 0.69501349055661 1 27.2 27 2 abnormal NMDA-mediated synaptic currents 0.00865209310543295 0.0354571316805298 0.69501349055661 1 27.2 27 2 absent posterior semicircular canal 0.00865209310543295 0.0354571316805298 0.69501349055661 1 27.2 27 2 abnormal abdominal wall morphology 0.00865209310543295 0.0354571316805298 0.69501349055661 1 27.2 27 2 premature bone ossification 0.00865209310543295 0.0354571316805298 0.69501349055661 1 27.2 27 2 premature neuronal precursor differentiation 0.00865209310543295 0.0354571316805298 0.69501349055661 1 27.2 27 2 decreased cellular sensitivity to ionizing radiation 0.00865209310543295 0.0354571316805298 0.69501349055661 1 27.2 27 2 abnormal proprioceptive neuron morphology 0.00865209310543295 0.0354571316805298 0.69501349055661 1 27.2 27 2 short frontal bone 0.00865209310543295 0.0354571316805298 0.69501349055661 1 27.2 27 2 increased neuronal precursor cell number 0.00865209310543295 0.0354571316805298 0.69501349055661 1 27.2 27 2 abnormal gallbladder physiology 0.00865209310543295 0.0354571316805298 0.69501349055661 1 27.2 27 2 abnormal posterior eye segment morphology 0.00865209310543295 0.0354571316805298 0.69501349055661 1 27.2 27 2 abnormal intervertebral disk development 0.00865209310543295 0.0354571316805298 0.69501349055661 1 27.2 27 2 positive geotaxis 0.00865209310543295 0.0354571316805298 0.69501349055661 1 27.2 27 2 abnormal leukopoiesis 0.00865209310543295 0.0354571316805298 0.69501349055661 1 27.2 27 2 abnormal liver vasculature morphology 0.00865209310543295 0.0354571316805298 0.69501349055661 1 27.2 27 2 abnormal hyoid bone lesser horn morphology 0.00865209310543295 0.0354571316805298 0.69501349055661 1 27.2 27 2 decreased transitional stage T1 B cell number 0.00865209310543295 0.0354571316805298 0.69501349055661 1 27.2 27 2 abnormal hippocampus granule cell morphology 0.00865209310543295 0.0354571316805298 0.69501349055661 1 27.2 27 2 abnormal cerebellar layer morphology 0.00865209310543295 0.0354571316805298 0.69501349055661 1 27.2 27 2 axonal spheroids 0.00865209310543295 0.0354571316805298 0.69501349055661 1 27.2 27 2 abnormal heart left ventricle pressure 0.00865209310543295 0.0354571316805298 0.69501349055661 1 27.2 27 2 decreased effector memory CD4-positive, alpha-beta T cell number 0.00865209310543295 0.0354571316805298 0.69501349055661 1 27.2 27 2 decreased airway resistance 0.00865209310543295 0.0354571316805298 0.69501349055661 1 27.2 27 2 abnormal lung lobe morphology 0.00865209310543295 0.0354571316805298 0.69501349055661 1 27.2 27 2 reduced AMPA-mediated synaptic currents 0.00865209310543295 0.0354571316805298 0.69501349055661 1 27.2 27 2 increased myeloid cell number 0.00865209310543295 0.0354571316805298 0.69501349055661 1 27.2 27 2 abnormal ductus venosus valve topology 0.00865209310543295 0.0354571316805298 0.69501349055661 1 27.2 27 2 abnormal infrahyoid muscle connection 0.00865209310543295 0.0354571316805298 0.69501349055661 1 27.2 27 2 symmetric azygos veins 0.00865209310543295 0.0354571316805298 0.69501349055661 1 27.2 27 2 increased cardiac muscle glycogen level 0.00865209310543295 0.0354571316805298 0.69501349055661 1 27.2 27 2 cerebellum atrophy 0.00865209310543295 0.0354571316805298 0.69501349055661 1 27.2 27 2 decreased platelet dense granule number 0.00865209310543295 0.0354571316805298 0.69501349055661 1 27.2 27 2 growth retardation of molars 0.0248657180913926 0.0826918098293303 0.69501349055661 1 27.2 27 2 asymmetric rib joints 0.0248657180913926 0.0826918098293303 0.69501349055661 1 27.2 27 2 failure of atrioventricular cushion closure 0.0248657180913926 0.0826918098293303 0.69501349055661 1 27.2 27 2 broad head 0.0248657180913926 0.0826918098293303 0.69501349055661 1 27.2 27 2 absent hair follicles 0.0248657180913926 0.0826918098293303 0.69501349055661 1 27.2 27 2 mammary gland hyperplasia 0.0248657180913926 0.0826918098293303 0.69501349055661 1 27.2 27 2 skin photosensitivity 0.0248657180913926 0.0826918098293303 0.69501349055661 1 27.2 27 2 absent epidermis stratum corneum 0.0248657180913926 0.0826918098293303 0.69501349055661 1 27.2 27 2 retina hyperplasia 0.0248657180913926 0.0826918098293303 0.69501349055661 1 27.2 27 2 excessive tearing 0.0248657180913926 0.0826918098293303 0.69501349055661 1 27.2 27 2 abnormal circulating alanine transaminase level 0.0248657180913926 0.0826918098293303 0.69501349055661 1 27.2 27 2 abnormal tumor incidence 0.0248657180913926 0.0826918098293303 0.69501349055661 1 27.2 27 2 abnormal brain ventricular system morphology 0.0248657180913926 0.0826918098293303 0.69501349055661 1 27.2 27 2 abnormal melanocyte morphology 0.0248657180913926 0.0826918098293303 0.69501349055661 1 27.2 27 2 abnormal adrenal gland physiology 0.0248657180913926 0.0826918098293303 0.69501349055661 1 27.2 27 2 abnormal inhibitory postsynaptic potential 0.0248657180913926 0.0826918098293303 0.69501349055661 1 27.2 27 2 decreased mortality induced by ionizing radiation 0.0248657180913926 0.0826918098293303 0.69501349055661 1 27.2 27 2 decreased lateral semicircular canal size 0.0248657180913926 0.0826918098293303 0.69501349055661 1 27.2 27 2 decreased cardiomyocyte apoptosis 0.0248657180913926 0.0826918098293303 0.69501349055661 1 27.2 27 2 abnormal sinus venosus morphology 0.0248657180913926 0.0826918098293303 0.69501349055661 1 27.2 27 2 aorta coarctation 0.0248657180913926 0.0826918098293303 0.69501349055661 1 27.2 27 2 abnormal neurotransmitter uptake 0.0248657180913926 0.0826918098293303 0.69501349055661 1 27.2 27 2 abnormal response to novel odor 0.0248657180913926 0.0826918098293303 0.69501349055661 1 27.2 27 2 increased cell nucleus count 0.0248657180913926 0.0826918098293303 0.69501349055661 1 27.2 27 2 abnormal central pattern generator function 0.0248657180913926 0.0826918098293303 0.69501349055661 1 27.2 27 2 abnormal Purkinje cell innervation 0.0248657180913926 0.0826918098293303 0.69501349055661 1 27.2 27 2 renal necrosis 0.0248657180913926 0.0826918098293303 0.69501349055661 1 27.2 27 2 abnormal optic tract morphology 0.0248657180913926 0.0826918098293303 0.69501349055661 1 27.2 27 2 absent vestibular saccule 0.0248657180913926 0.0826918098293303 0.69501349055661 1 27.2 27 2 abnormal vestibular saccular macula morphology 0.0248657180913926 0.0826918098293303 0.69501349055661 1 27.2 27 2 absent deltoid tuberosity 0.0248657180913926 0.0826918098293303 0.69501349055661 1 27.2 27 2 absent ulna 0.0248657180913926 0.0826918098293303 0.69501349055661 1 27.2 27 2 abnormal cochlear nerve compound action potential 0.0248657180913926 0.0826918098293303 0.69501349055661 1 27.2 27 2 abnormal negative T cell selection 0.0248657180913926 0.0826918098293303 0.69501349055661 1 27.2 27 2 increased thyroid-stimulating hormone level 0.0248657180913926 0.0826918098293303 0.69501349055661 1 27.2 27 2 absent fibula 0.0248657180913926 0.0826918098293303 0.69501349055661 1 27.2 27 2 abnormal thyroid hormone level 0.0248657180913926 0.0826918098293303 0.69501349055661 1 27.2 27 2 decreased tidal volume 0.0248657180913926 0.0826918098293303 0.69501349055661 1 27.2 27 2 abnormal uterus physiology 0.0248657180913926 0.0826918098293303 0.69501349055661 1 27.2 27 2 heart hemorrhage 0.0248657180913926 0.0826918098293303 0.69501349055661 1 27.2 27 2 postaxial polydactyly 0.0248657180913926 0.0826918098293303 0.69501349055661 1 27.2 27 2 abnormal cerebellum white matter morphology 0.0248657180913926 0.0826918098293303 0.69501349055661 1 27.2 27 2 decreased DN2 thymocyte number 0.0248657180913926 0.0826918098293303 0.69501349055661 1 27.2 27 2 increased oligodendrocyte number 0.0248657180913926 0.0826918098293303 0.69501349055661 1 27.2 27 2 decreased brain cholesterol level 0.0248657180913926 0.0826918098293303 0.69501349055661 1 27.2 27 2 abnormal retina inner limiting membrane morphology 0.0248657180913926 0.0826918098293303 0.69501349055661 1 27.2 27 2 decreased skeletal muscle glycogen level 0.0248657180913926 0.0826918098293303 0.69501349055661 1 27.2 27 2 long stride length 0.0248657180913926 0.0826918098293303 0.69501349055661 1 27.2 27 2 abnormal aortic valve cusp morphology 0.0248657180913926 0.0826918098293303 0.69501349055661 1 27.2 27 2 thick mitral valve cusps 0.0248657180913926 0.0826918098293303 0.69501349055661 1 27.2 27 2 dilated pulmonary alveolar ducts 0.0248657180913926 0.0826918098293303 0.69501349055661 1 27.2 27 2 small lung lobe 0.0248657180913926 0.0826918098293303 0.69501349055661 1 27.2 27 2 abnormal outer hair cell kinocilium morphology 0.0248657180913926 0.0826918098293303 0.69501349055661 1 27.2 27 2 abnormal brain ependyma motile cilium physiology 0.0248657180913926 0.0826918098293303 0.69501349055661 1 27.2 27 2 parturition failure 0.0248657180913926 0.0826918098293303 0.69501349055661 1 27.2 27 2 small tail bud 0.0248657180913926 0.0826918098293303 0.69501349055661 1 27.2 27 2 decreased CD8-positive, naive alpha-beta T cell number 0.0248657180913926 0.0826918098293303 0.69501349055661 1 27.2 27 2 decreased areal bone mineral density 0.0248657180913926 0.0826918098293303 0.69501349055661 1 27.2 27 2 decreased femur compact bone thickness 0.0248657180913926 0.0826918098293303 0.69501349055661 1 27.2 27 2 ductus venosus stenosis 0.0248657180913926 0.0826918098293303 0.69501349055661 1 27.2 27 2 fragmented Meckel's cartilage 0.0248657180913926 0.0826918098293303 0.69501349055661 1 27.2 27 2 absent connection between subcutaneous lymph vessels and lymph sac 0.0248657180913926 0.0826918098293303 0.69501349055661 1 27.2 27 2 decreased collagen level 0.0248657180913926 0.0826918098293303 0.69501349055661 1 27.2 27 2 abnormal ear shape 0.0421529101471339 0.120797179207342 0.69501349055661 1 27.2 27 2 large anterior fontanelle 0.0421529101471339 0.120797179207342 0.69501349055661 1 27.2 27 2 arrest of tooth development 0.0421529101471339 0.120797179207342 0.69501349055661 1 27.2 27 2 poor arterial differentiation 0.0421529101471339 0.120797179207342 0.69501349055661 1 27.2 27 2 abnormal urethra morphology 0.0421529101471339 0.120797179207342 0.69501349055661 1 27.2 27 2 absent limbs 0.0421529101471339 0.120797179207342 0.69501349055661 1 27.2 27 2 thin tail 0.0421529101471339 0.120797179207342 0.69501349055661 1 27.2 27 2 abnormal lacrimal gland physiology 0.0421529101471339 0.120797179207342 0.69501349055661 1 27.2 27 2 hyperresponsive 0.0421529101471339 0.120797179207342 0.69501349055661 1 27.2 27 2 jumpy 0.0421529101471339 0.120797179207342 0.69501349055661 1 27.2 27 2 abnormal avoidance learning behavior 0.0421529101471339 0.120797179207342 0.69501349055661 1 27.2 27 2 absent ectoplacental cone 0.0421529101471339 0.120797179207342 0.69501349055661 1 27.2 27 2 delayed brain development 0.0421529101471339 0.120797179207342 0.69501349055661 1 27.2 27 2 non-obstructive hydrocephaly 0.0421529101471339 0.120797179207342 0.69501349055661 1 27.2 27 2 reduced NMDA-mediated synaptic currents 0.0421529101471339 0.120797179207342 0.69501349055661 1 27.2 27 2 abnormal chemically-elicited antinociception 0.0421529101471339 0.120797179207342 0.69501349055661 1 27.2 27 2 abnormal blood gas level 0.0421529101471339 0.120797179207342 0.69501349055661 1 27.2 27 2 abnormal pulmonary ventilation 0.0421529101471339 0.120797179207342 0.69501349055661 1 27.2 27 2 chromatolysis 0.0421529101471339 0.120797179207342 0.69501349055661 1 27.2 27 2 increased post-tetanic potentiation 0.0421529101471339 0.120797179207342 0.69501349055661 1 27.2 27 2 abnormal hippocampal fimbria morphology 0.0421529101471339 0.120797179207342 0.69501349055661 1 27.2 27 2 absent cochlea 0.0421529101471339 0.120797179207342 0.69501349055661 1 27.2 27 2 decreased posterior semicircular canal size 0.0421529101471339 0.120797179207342 0.69501349055661 1 27.2 27 2 phenotypic reversion 0.0421529101471339 0.120797179207342 0.69501349055661 1 27.2 27 2 calcified joint 0.0421529101471339 0.120797179207342 0.69501349055661 1 27.2 27 2 loss of hippocampal neurons 0.0421529101471339 0.120797179207342 0.69501349055661 1 27.2 27 2 bile duct inflammation 0.0421529101471339 0.120797179207342 0.69501349055661 1 27.2 27 2 esophageal atresia 0.0421529101471339 0.120797179207342 0.69501349055661 1 27.2 27 2 decreased liver function 0.0421529101471339 0.120797179207342 0.69501349055661 1 27.2 27 2 impaired granulosa cell differentiation 0.0421529101471339 0.120797179207342 0.69501349055661 1 27.2 27 2 increased glycerol level 0.0421529101471339 0.120797179207342 0.69501349055661 1 27.2 27 2 enlarged pancreas 0.0421529101471339 0.120797179207342 0.69501349055661 1 27.2 27 2 abnormal leukocyte tethering or rolling 0.0421529101471339 0.120797179207342 0.69501349055661 1 27.2 27 2 fusion of middle ear ossicles 0.0421529101471339 0.120797179207342 0.69501349055661 1 27.2 27 2 abnormal milk ejection 0.0421529101471339 0.120797179207342 0.69501349055661 1 27.2 27 2 abnormal metopic suture morphology 0.0421529101471339 0.120797179207342 0.69501349055661 1 27.2 27 2 matted coat 0.0421529101471339 0.120797179207342 0.69501349055661 1 27.2 27 2 abnormal ST segment 0.0421529101471339 0.120797179207342 0.69501349055661 1 27.2 27 2 shortened QT interval 0.0421529101471339 0.120797179207342 0.69501349055661 1 27.2 27 2 absent molars 0.0421529101471339 0.120797179207342 0.69501349055661 1 27.2 27 2 abnormal extensor digitorum longus morphology 0.0421529101471339 0.120797179207342 0.69501349055661 1 27.2 27 2 abnormal physical strength 0.0421529101471339 0.120797179207342 0.69501349055661 1 27.2 27 2 vestibular saccular degeneration 0.0421529101471339 0.120797179207342 0.69501349055661 1 27.2 27 2 small clavicle 0.0421529101471339 0.120797179207342 0.69501349055661 1 27.2 27 2 short scapula 0.0421529101471339 0.120797179207342 0.69501349055661 1 27.2 27 2 enlarged interparietal bone 0.0421529101471339 0.120797179207342 0.69501349055661 1 27.2 27 2 absent parietal bone 0.0421529101471339 0.120797179207342 0.69501349055661 1 27.2 27 2 abnormal common crus morphology 0.0421529101471339 0.120797179207342 0.69501349055661 1 27.2 27 2 decreased prostate gland weight 0.0421529101471339 0.120797179207342 0.69501349055661 1 27.2 27 2 abnormal blastocoele morphology 0.0421529101471339 0.120797179207342 0.69501349055661 1 27.2 27 2 abnormal immature B cell morphology 0.0421529101471339 0.120797179207342 0.69501349055661 1 27.2 27 2 abnormal anus morphology 0.0421529101471339 0.120797179207342 0.69501349055661 1 27.2 27 2 osteomyelitis 0.0421529101471339 0.120797179207342 0.69501349055661 1 27.2 27 2 increased triiodothyronine level 0.0421529101471339 0.120797179207342 0.69501349055661 1 27.2 27 2 abnormal ligament morphology 0.0421529101471339 0.120797179207342 0.69501349055661 1 27.2 27 2 abnormal dermis papillary layer morphology 0.0421529101471339 0.120797179207342 0.69501349055661 1 27.2 27 2 decreased platelet ADP level 0.0421529101471339 0.120797179207342 0.69501349055661 1 27.2 27 2 abnormal right lung morphology 0.0421529101471339 0.120797179207342 0.69501349055661 1 27.2 27 2 abnormal eyelid development 0.0421529101471339 0.120797179207342 0.69501349055661 1 27.2 27 2 abnormal thromboxane level 0.0421529101471339 0.120797179207342 0.69501349055661 1 27.2 27 2 abnormal neural crest cell morphology 0.0421529101471339 0.120797179207342 0.69501349055661 1 27.2 27 2 abnormal aorta tunica adventitia morphology 0.0421529101471339 0.120797179207342 0.69501349055661 1 27.2 27 2 exostosis 0.0421529101471339 0.120797179207342 0.69501349055661 1 27.2 27 2 ectopic hippocampus pyramidal cells 0.0421529101471339 0.120797179207342 0.69501349055661 1 27.2 27 2 visceral vascular congestion 0.0421529101471339 0.120797179207342 0.69501349055661 1 27.2 27 2 abnormal orbit morphology 0.0421529101471339 0.120797179207342 0.69501349055661 1 27.2 27 2 increased erythrocyte clearance 0.0421529101471339 0.120797179207342 0.69501349055661 1 27.2 27 2 abnormal oval cell physiology 0.0421529101471339 0.120797179207342 0.69501349055661 1 27.2 27 2 abnormal synaptic dopamine release 0.0421529101471339 0.120797179207342 0.69501349055661 1 27.2 27 2 enlarged lymphatic vessel 0.0421529101471339 0.120797179207342 0.69501349055661 1 27.2 27 2 abnormal heart right ventricle outflow tract morphology 0.0421529101471339 0.120797179207342 0.69501349055661 1 27.2 27 2 kidney microaneurysm 0.0421529101471339 0.120797179207342 0.69501349055661 1 27.2 27 2 myocardium hypoplasia 0.0421529101471339 0.120797179207342 0.69501349055661 1 27.2 27 2 cerebral arteriovenous malformation 0.0421529101471339 0.120797179207342 0.69501349055661 1 27.2 27 2 thick pulmonary valve cusps 0.0421529101471339 0.120797179207342 0.69501349055661 1 27.2 27 2 thick myocardium 0.0421529101471339 0.120797179207342 0.69501349055661 1 27.2 27 2 persistent hyperplastic primary vitreous 0.0421529101471339 0.120797179207342 0.69501349055661 1 27.2 27 2 abnormal intestinal enteroendocrine cell morphology 0.0421529101471339 0.120797179207342 0.69501349055661 1 27.2 27 2 increased total lung capacity 0.0421529101471339 0.120797179207342 0.69501349055661 1 27.2 27 2 abnormal mandibular prominence morphology 0.0421529101471339 0.120797179207342 0.69501349055661 1 27.2 27 2 decreased macrophage nitric oxide production 0.0421529101471339 0.120797179207342 0.69501349055661 1 27.2 27 2 abnormal ureteric bud tip morphology 0.0421529101471339 0.120797179207342 0.69501349055661 1 27.2 27 2 abnormal kidney collecting duct epithelium morphology 0.0421529101471339 0.120797179207342 0.69501349055661 1 27.2 27 2 delayed limb development 0.0421529101471339 0.120797179207342 0.69501349055661 1 27.2 27 2 increased bone trabecular spacing 0.0421529101471339 0.120797179207342 0.69501349055661 1 27.2 27 2 increased effector memory T-helper cell number 0.0421529101471339 0.120797179207342 0.69501349055661 1 27.2 27 2 abnormal vertebral artery origin 0.0421529101471339 0.120797179207342 0.69501349055661 1 27.2 27 2 additional anastomosis between intracranial vertebral arteries 0.0421529101471339 0.120797179207342 0.69501349055661 1 27.2 27 2 abnormal Wolffian duct connection 0.0421529101471339 0.120797179207342 0.69501349055661 1 27.2 27 2 decreased hippocampus volume 0.0421529101471339 0.120797179207342 0.69501349055661 1 27.2 27 2 decreased tear production 0.0421529101471339 0.120797179207342 0.69501349055661 1 27.2 27 2 decreased capillary density 0.0421529101471339 0.120797179207342 0.69501349055661 1 27.2 27 2 abnormal inhibitory learning 0.0421529101471339 0.120797179207342 0.69501349055661 1 27.2 27 2 abnormal excitatory synapse morphology 0.0421529101471339 0.120797179207342 0.69501349055661 1 27.2 27 2 decreased retinal apoptosis 0.0421529101471339 0.120797179207342 0.69501349055661 1 27.2 27 2 increased cardiac cell glucose uptake 0.0421529101471339 0.120797179207342 0.69501349055661 1 27.2 27 2 absent scala media 0.0714570722815051 0.180181923264312 0.69501349055661 1 27.2 27 2 absent neurocranium 0.0714570722815051 0.180181923264312 0.69501349055661 1 27.2 27 2 absent ribs 0.0714570722815051 0.180181923264312 0.69501349055661 1 27.2 27 2 abnormal circulating HDL cholesterol level 0.0714570722815051 0.180181923264312 0.69501349055661 1 27.2 27 2 decreased mast cell histamine storage 0.0714570722815051 0.180181923264312 0.69501349055661 1 27.2 27 2 head blaze 0.0714570722815051 0.180181923264312 0.69501349055661 1 27.2 27 2 small hair follicles 0.0714570722815051 0.180181923264312 0.69501349055661 1 27.2 27 2 delayed intestine development 0.0714570722815051 0.180181923264312 0.69501349055661 1 27.2 27 2 abnormal pulmonary trunk morphology 0.0714570722815051 0.180181923264312 0.69501349055661 1 27.2 27 2 absent hindlimb 0.0714570722815051 0.180181923264312 0.69501349055661 1 27.2 27 2 ulcerated paws 0.0714570722815051 0.180181923264312 0.69501349055661 1 27.2 27 2 abnormal pineal gland morphology 0.0714570722815051 0.180181923264312 0.69501349055661 1 27.2 27 2 optic nerve atrophy 0.0714570722815051 0.180181923264312 0.69501349055661 1 27.2 27 2 abnormal vestibulocochlear nerve morphology 0.0714570722815051 0.180181923264312 0.69501349055661 1 27.2 27 2 ovary hyperplasia 0.0714570722815051 0.180181923264312 0.69501349055661 1 27.2 27 2 absent prostate gland 0.0714570722815051 0.180181923264312 0.69501349055661 1 27.2 27 2 absent lungs 0.0714570722815051 0.180181923264312 0.69501349055661 1 27.2 27 2 decreased sensitivity to skin irradiation 0.0714570722815051 0.180181923264312 0.69501349055661 1 27.2 27 2 skin hyperplasia 0.0714570722815051 0.180181923264312 0.69501349055661 1 27.2 27 2 kinked vibrissae 0.0714570722815051 0.180181923264312 0.69501349055661 1 27.2 27 2 corneal scarring 0.0714570722815051 0.180181923264312 0.69501349055661 1 27.2 27 2 athetotic walking movements 0.0714570722815051 0.180181923264312 0.69501349055661 1 27.2 27 2 abnormal respiratory sounds 0.0714570722815051 0.180181923264312 0.69501349055661 1 27.2 27 2 increased hepatic hemangioma incidence 0.0714570722815051 0.180181923264312 0.69501349055661 1 27.2 27 2 abnormal nasal mucosa morphology 0.0714570722815051 0.180181923264312 0.69501349055661 1 27.2 27 2 abnormal oropharynx morphology 0.0714570722815051 0.180181923264312 0.69501349055661 1 27.2 27 2 abnormal type I pneumocyte morphology 0.0714570722815051 0.180181923264312 0.69501349055661 1 27.2 27 2 anoxia 0.0714570722815051 0.180181923264312 0.69501349055661 1 27.2 27 2 hypercapnia 0.0714570722815051 0.180181923264312 0.69501349055661 1 27.2 27 2 improved righting response 0.0714570722815051 0.180181923264312 0.69501349055661 1 27.2 27 2 decreased superior colliculus size 0.0714570722815051 0.180181923264312 0.69501349055661 1 27.2 27 2 cerebral aqueductal stenosis 0.0714570722815051 0.180181923264312 0.69501349055661 1 27.2 27 2 increased urine microalbumin level 0.0714570722815051 0.180181923264312 0.69501349055661 1 27.2 27 2 absent malleus processus brevis 0.0714570722815051 0.180181923264312 0.69501349055661 1 27.2 27 2 abnormal esophagus development 0.0714570722815051 0.180181923264312 0.69501349055661 1 27.2 27 2 absent superior semicircular canal 0.0714570722815051 0.180181923264312 0.69501349055661 1 27.2 27 2 decreased lysosomal enzyme secretion 0.0714570722815051 0.180181923264312 0.69501349055661 1 27.2 27 2 increased lysosomal enzyme secretion 0.0714570722815051 0.180181923264312 0.69501349055661 1 27.2 27 2 enhanced NMDA-mediated synaptic currents 0.0714570722815051 0.180181923264312 0.69501349055661 1 27.2 27 2 bile duct proliferation 0.0714570722815051 0.180181923264312 0.69501349055661 1 27.2 27 2 gastric polyps 0.0714570722815051 0.180181923264312 0.69501349055661 1 27.2 27 2 epidermal cyst 0.0714570722815051 0.180181923264312 0.69501349055661 1 27.2 27 2 premature endochondral bone ossification 0.0714570722815051 0.180181923264312 0.69501349055661 1 27.2 27 2 sirenomelia 0.0714570722815051 0.180181923264312 0.69501349055661 1 27.2 27 2 absent vas deferens 0.0714570722815051 0.180181923264312 0.69501349055661 1 27.2 27 2 absent uterus 0.0714570722815051 0.180181923264312 0.69501349055661 1 27.2 27 2 abnormal response to vitamins 0.0714570722815051 0.180181923264312 0.69501349055661 1 27.2 27 2 abnormal hypodermis morphology 0.0714570722815051 0.180181923264312 0.69501349055661 1 27.2 27 2 ectopic cartilage 0.0714570722815051 0.180181923264312 0.69501349055661 1 27.2 27 2 absent heart right ventricle 0.0714570722815051 0.180181923264312 0.69501349055661 1 27.2 27 2 increased heart right ventricle weight 0.0714570722815051 0.180181923264312 0.69501349055661 1 27.2 27 2 abnormal Descemet membrane 0.0714570722815051 0.180181923264312 0.69501349055661 1 27.2 27 2 absent inner ear vestibule 0.0714570722815051 0.180181923264312 0.69501349055661 1 27.2 27 2 scapular bone foramen 0.0714570722815051 0.180181923264312 0.69501349055661 1 27.2 27 2 absent utricle 0.0714570722815051 0.180181923264312 0.69501349055661 1 27.2 27 2 absent frontal bone 0.0714570722815051 0.180181923264312 0.69501349055661 1 27.2 27 2 abnormal inner cell mass proliferation 0.0714570722815051 0.180181923264312 0.69501349055661 1 27.2 27 2 abnormal tail pigmentation 0.0714570722815051 0.180181923264312 0.69501349055661 1 27.2 27 2 abnormal iris pigment epithelium 0.0714570722815051 0.180181923264312 0.69501349055661 1 27.2 27 2 abnormal olfactory cortex morphology 0.0714570722815051 0.180181923264312 0.69501349055661 1 27.2 27 2 decreased unsaturated fatty acid level 0.0714570722815051 0.180181923264312 0.69501349055661 1 27.2 27 2 abnormal mesangial cell morphology 0.0714570722815051 0.180181923264312 0.69501349055661 1 27.2 27 2 growth retardation of incisors 0.0714570722815051 0.180181923264312 0.69501349055661 1 27.2 27 2 corneal deposits 0.0714570722815051 0.180181923264312 0.69501349055661 1 27.2 27 2 abnormal hemoglobin content 0.0714570722815051 0.180181923264312 0.69501349055661 1 27.2 27 2 abnormal optokinetic reflex 0.0714570722815051 0.180181923264312 0.69501349055661 1 27.2 27 2 increased placenta apoptosis 0.0714570722815051 0.180181923264312 0.69501349055661 1 27.2 27 2 absent optic chiasm 0.0714570722815051 0.180181923264312 0.69501349055661 1 27.2 27 2 enhanced behavioral response to anesthetic 0.0714570722815051 0.180181923264312 0.69501349055661 1 27.2 27 2 abnormal mismatch repair 0.0714570722815051 0.180181923264312 0.69501349055661 1 27.2 27 2 decreased leukotriene level 0.0714570722815051 0.180181923264312 0.69501349055661 1 27.2 27 2 enlarged eye anterior chamber 0.0714570722815051 0.180181923264312 0.69501349055661 1 27.2 27 2 decreased neural crest cell number 0.0714570722815051 0.180181923264312 0.69501349055661 1 27.2 27 2 abnormal arcus anterior morphology 0.0714570722815051 0.180181923264312 0.69501349055661 1 27.2 27 2 palatal shelf fusion with tongue or mandible 0.0714570722815051 0.180181923264312 0.69501349055661 1 27.2 27 2 abnormal tail hair pigmentation 0.0714570722815051 0.180181923264312 0.69501349055661 1 27.2 27 2 abnormal olfactory bulb granule cell layer morphology 0.0714570722815051 0.180181923264312 0.69501349055661 1 27.2 27 2 abnormal cerebellum lobule morphology 0.0714570722815051 0.180181923264312 0.69501349055661 1 27.2 27 2 aciduria 0.0714570722815051 0.180181923264312 0.69501349055661 1 27.2 27 2 abnormal cranium size 0.0714570722815051 0.180181923264312 0.69501349055661 1 27.2 27 2 abnormal primitive urogenital sinus morphology 0.0714570722815051 0.180181923264312 0.69501349055661 1 27.2 27 2 decreased DN3 thymocyte number 0.0714570722815051 0.180181923264312 0.69501349055661 1 27.2 27 2 hemolysis 0.0714570722815051 0.180181923264312 0.69501349055661 1 27.2 27 2 increased response to stress-induced hyperthermia 0.0714570722815051 0.180181923264312 0.69501349055661 1 27.2 27 2 increased mammary gland epithelial cell proliferation 0.0714570722815051 0.180181923264312 0.69501349055661 1 27.2 27 2 leptocytosis 0.0714570722815051 0.180181923264312 0.69501349055661 1 27.2 27 2 increased T follicular helper cell number 0.0714570722815051 0.180181923264312 0.69501349055661 1 27.2 27 2 abnormal heart ventricle outflow tract morphology 0.0714570722815051 0.180181923264312 0.69501349055661 1 27.2 27 2 decreased lung tumor incidence 0.0714570722815051 0.180181923264312 0.69501349055661 1 27.2 27 2 increased thyroid carcinoma incidence 0.0714570722815051 0.180181923264312 0.69501349055661 1 27.2 27 2 decreased QRS amplitude 0.0714570722815051 0.180181923264312 0.69501349055661 1 27.2 27 2 calcified aorta 0.0714570722815051 0.180181923264312 0.69501349055661 1 27.2 27 2 aorta hypoplasia 0.0714570722815051 0.180181923264312 0.69501349055661 1 27.2 27 2 prolonged ST segment 0.0714570722815051 0.180181923264312 0.69501349055661 1 27.2 27 2 decreased heart left ventricle size 0.0714570722815051 0.180181923264312 0.69501349055661 1 27.2 27 2 enlarged aortic valve 0.0714570722815051 0.180181923264312 0.69501349055661 1 27.2 27 2 ventricular myocardium compact layer hypoplasia 0.0714570722815051 0.180181923264312 0.69501349055661 1 27.2 27 2 abnormal blood pressure regulation 0.0714570722815051 0.180181923264312 0.69501349055661 1 27.2 27 2 abnormal paranode morphology 0.0714570722815051 0.180181923264312 0.69501349055661 1 27.2 27 2 increased Schwann cell number 0.0714570722815051 0.180181923264312 0.69501349055661 1 27.2 27 2 preweaning lethality 0.0714570722815051 0.180181923264312 0.69501349055661 1 27.2 27 2 trachea stenosis 0.0714570722815051 0.180181923264312 0.69501349055661 1 27.2 27 2 pale lung 0.0714570722815051 0.180181923264312 0.69501349055661 1 27.2 27 2 pulmonary alveolar edema 0.0714570722815051 0.180181923264312 0.69501349055661 1 27.2 27 2 alveolitis 0.0714570722815051 0.180181923264312 0.69501349055661 1 27.2 27 2 fused right lung lobes 0.0714570722815051 0.180181923264312 0.69501349055661 1 27.2 27 2 abnormal nephrogenic mesenchyme morphogenesis 0.0714570722815051 0.180181923264312 0.69501349055661 1 27.2 27 2 abnormal lung alveolus development 0.0714570722815051 0.180181923264312 0.69501349055661 1 27.2 27 2 abnormal circadian regulation of heart rate 0.0714570722815051 0.180181923264312 0.69501349055661 1 27.2 27 2 abnormal circadian regulation of systemic arterial blood pressure 0.0714570722815051 0.180181923264312 0.69501349055661 1 27.2 27 2 impaired branching involved in terminal bronchiole morphogenesis 0.0714570722815051 0.180181923264312 0.69501349055661 1 27.2 27 2 decreased pre-pro B cell number 0.0714570722815051 0.180181923264312 0.69501349055661 1 27.2 27 2 midface hypoplasia 0.0714570722815051 0.180181923264312 0.69501349055661 1 27.2 27 2 absent nodal flow 0.0714570722815051 0.180181923264312 0.69501349055661 1 27.2 27 2 delayed optic fissure closure 0.0714570722815051 0.180181923264312 0.69501349055661 1 27.2 27 2 decreased Paneth cell number 0.0714570722815051 0.180181923264312 0.69501349055661 1 27.2 27 2 abnormal eyelid margin morphology 0.0714570722815051 0.180181923264312 0.69501349055661 1 27.2 27 2 abnormal mitophagy 0.0714570722815051 0.180181923264312 0.69501349055661 1 27.2 27 2 decreased small intestinal villus height 0.0714570722815051 0.180181923264312 0.69501349055661 1 27.2 27 2 increased heart iron level 0.0714570722815051 0.180181923264312 0.69501349055661 1 27.2 27 2 decreased fibroblast chemotaxis 0.0714570722815051 0.180181923264312 0.69501349055661 1 27.2 27 2 decreased platelet alpha-granule number 0.0714570722815051 0.180181923264312 0.69501349055661 1 27.2 27 2 domed cranium 4.30277719978239e-15 2.16225419888055e-13 0.685084726405802 0.985714285714286 27.2 27 2 abnormal cued conditioning behavior 7.30318045095963e-11 1.97463710562631e-09 0.6813857750555 0.980392156862745 27.2 27 2 short stride length 1.21547859599811e-10 3.21649256121839e-09 0.681113220745478 0.98 27.2 27 2 pulmonary hypoplasia 5.58969208323033e-10 1.32422467209861e-08 0.680225969480938 0.978723404255319 27.2 27 2 increased cellular sensitivity to gamma-irradiation 5.58969208323033e-10 1.32422467209861e-08 0.680225969480938 0.978723404255319 27.2 27 2 failure to gastrulate 9.28730456004583e-10 2.10019728119218e-08 0.679904501631467 0.978260869565217 27.2 27 2 spina bifida 7.04353187977625e-09 1.40729201212397e-07 0.678465550305262 0.976190476190476 27.2 27 2 abnormal excitatory postsynaptic currents 1.89984790524492e-15 1.0273634052819e-13 0.67719263182439 0.974358974358974 27.2 27 2 decreased width of hypertrophic chondrocyte zone 8.75341559733501e-08 1.36088258114818e-06 0.676229342163189 0.972972972972973 27.2 27 2 abnormal lysosome morphology 1.44611189445055e-07 2.15401397451841e-06 0.675707560263371 0.972222222222222 27.2 27 2 narrow eye opening 1.44611189445055e-07 2.15401397451841e-06 0.675707560263371 0.972222222222222 27.2 27 2 increased cardiomyocyte apoptosis 6.49069548793833e-07 8.70383020282835e-06 0.673952475691259 0.96969696969697 27.2 27 2 abnormal locomotor coordination 6.49069548793833e-07 8.70383020282835e-06 0.673952475691259 0.96969696969697 27.2 27 2 abnormal QRS complex 6.49069548793833e-07 8.70383020282835e-06 0.673952475691259 0.96969696969697 27.2 27 2 pancreatic islet hyperplasia 1.06888379140459e-06 1.37054042841182e-05 0.673294318976716 0.96875 27.2 27 2 osteopetrosis 1.7586210087214e-06 2.14987128116313e-05 0.672593700538655 0.967741935483871 27.2 27 2 preaxial polydactyly 1.7586210087214e-06 2.14987128116313e-05 0.672593700538655 0.967741935483871 27.2 27 2 abnormal maternal nurturing 9.41618041509233e-12 2.83912106455057e-10 0.672226162997377 0.967213114754098 27.2 27 2 abnormal heart tube morphology 2.8906279255147e-06 3.39973378946469e-05 0.671846374204723 0.966666666666667 27.2 27 2 lordosis 4.74639201153491e-06 5.23576502381068e-05 0.671047508123624 0.96551724137931 27.2 27 2 abnormal spinal nerve morphology 4.74639201153491e-06 5.23576502381068e-05 0.671047508123624 0.96551724137931 27.2 27 2 abnormal outer ear morphology 4.74639201153491e-06 5.23576502381068e-05 0.671047508123624 0.96551724137931 27.2 27 2 blood in lymph vessels 4.74639201153491e-06 5.23576502381068e-05 0.671047508123624 0.96551724137931 27.2 27 2 incomplete embryo turning 6.83197812779122e-11 1.85732738720007e-09 0.670627052291466 0.964912280701754 27.2 27 2 shortened head 7.78497306073124e-06 7.9856166963171e-05 0.670191580179589 0.964285714285714 27.2 27 2 abnormal somite shape 7.78497306073124e-06 7.9856166963171e-05 0.670191580179589 0.964285714285714 27.2 27 2 straub tail 7.78497306073124e-06 7.9856166963171e-05 0.670191580179589 0.964285714285714 27.2 27 2 hypoxia 7.78497306073124e-06 7.9856166963171e-05 0.670191580179589 0.964285714285714 27.2 27 2 increased triglyceride level 7.78497306073124e-06 7.9856166963171e-05 0.670191580179589 0.964285714285714 27.2 27 2 prolonged QRS complex duration 7.78497306073124e-06 7.9856166963171e-05 0.670191580179589 0.964285714285714 27.2 27 2 reduced fertility 8.15453944902494e-25 9.89483750217051e-23 0.67001300528479 0.964028776978417 27.2 27 2 abnormal head morphology 1.83363813966141e-10 4.65426007388546e-09 0.669740272718188 0.963636363636364 27.2 27 2 abnormal learning/memory/conditioning 1.83363813966141e-10 4.65426007388546e-09 0.669740272718188 0.963636363636364 27.2 27 2 abnormal joint morphology 1.83363813966141e-10 4.65426007388546e-09 0.669740272718188 0.963636363636364 27.2 27 2 abnormal maxilla morphology 3.00105176052962e-10 7.35479433922899e-09 0.669272250165625 0.962962962962963 27.2 27 2 impaired limb coordination 3.00105176052962e-10 7.35479433922899e-09 0.669272250165625 0.962962962962963 27.2 27 2 abnormal atrioventricular cushion morphology 1.27538205613317e-05 0.000122727770391925 0.669272250165625 0.962962962962963 27.2 27 2 thin epidermis 1.27538205613317e-05 0.000122727770391925 0.669272250165625 0.962962962962963 27.2 27 2 abnormal brain commissure morphology 1.27538205613317e-05 0.000122727770391925 0.669272250165625 0.962962962962963 27.2 27 2 abnormal eye muscle morphology 1.27538205613317e-05 0.000122727770391925 0.669272250165625 0.962962962962963 27.2 27 2 abnormal skin appearance 1.27538205613317e-05 0.000122727770391925 0.669272250165625 0.962962962962963 27.2 27 2 abnormal visceral yolk sac morphology 2.09547147533477e-14 9.47724599071863e-13 0.668620573193701 0.962025316455696 27.2 27 2 increased embryonic tissue cell apoptosis 3.42450519446093e-14 1.48147072542984e-12 0.668282202458279 0.961538461538462 27.2 27 2 abnormal brain wave pattern 8.02222827354977e-10 1.85630630980977e-08 0.668282202458279 0.961538461538462 27.2 27 2 abnormal nasal bone morphology 2.08678288527888e-05 0.000194414697645364 0.668282202458279 0.961538461538462 27.2 27 2 ventricular hypoplasia 2.08678288527888e-05 0.000194414697645364 0.668282202458279 0.961538461538462 27.2 27 2 impaired balance 4.06115429781455e-18 2.97121215170991e-16 0.66775805955439 0.96078431372549 27.2 27 2 abnormal response to novel object 1.31019120931008e-09 2.92296020911104e-08 0.66775805955439 0.96078431372549 27.2 27 2 ataxia 1.25095543378718e-34 2.82886512867783e-32 0.667488203801893 0.96039603960396 27.2 27 2 abnormal cochlear outer hair cell morphology 3.40979368425438e-05 0.000300775240765347 0.667212950934346 0.96 27.2 27 2 kidney cysts 2.42999785757739e-13 9.26616115517972e-12 0.666837267966478 0.959459459459459 27.2 27 2 abnormal fertility/fecundity 3.96063515028192e-13 1.44883528475387e-11 0.666451292314558 0.958904109589041 27.2 27 2 abnormal digit morphology 6.45169941926412e-13 2.26036652189007e-11 0.666054595116752 0.958333333333333 27.2 27 2 hydrops fetalis 6.45169941926412e-13 2.26036652189007e-11 0.666054595116752 0.958333333333333 27.2 27 2 overriding aortic valve 5.68098164571086e-09 1.16308163322681e-07 0.666054595116752 0.958333333333333 27.2 27 2 vertebral transformation 5.68098164571086e-09 1.16308163322681e-07 0.666054595116752 0.958333333333333 27.2 27 2 curly tail 5.68098164571086e-09 1.16308163322681e-07 0.666054595116752 0.958333333333333 27.2 27 2 abnormal malleus morphology 5.5635025208054e-05 0.000469125848152659 0.666054595116752 0.958333333333333 27.2 27 2 abnormal digestive system morphology 5.5635025208054e-05 0.000469125848152659 0.666054595116752 0.958333333333333 27.2 27 2 increased stereotypic behavior 5.5635025208054e-05 0.000469125848152659 0.666054595116752 0.958333333333333 27.2 27 2 abnormal startle reflex 5.5635025208054e-05 0.000469125848152659 0.666054595116752 0.958333333333333 27.2 27 2 blindness 5.5635025208054e-05 0.000469125848152659 0.666054595116752 0.958333333333333 27.2 27 2 decreased fatty acid level 5.5635025208054e-05 0.000469125848152659 0.666054595116752 0.958333333333333 27.2 27 2 abnormal brain morphology 4.18654049417771e-27 6.12589381133357e-25 0.664795512706323 0.956521739130435 27.2 27 2 abnormal cell death 1.50425191315925e-08 2.79240793580869e-07 0.664795512706323 0.956521739130435 27.2 27 2 abnormal pulmonary artery morphology 9.06333324446749e-05 0.000722597482231182 0.664795512706323 0.956521739130435 27.2 27 2 limb grasping 2.21602500029731e-30 3.80162909533762e-28 0.66446344701566 0.956043956043956 27.2 27 2 abnormal autopod morphology 2.44441528130431e-08 4.23703642756017e-07 0.664124002087428 0.955555555555556 27.2 27 2 lethality at weaning, complete penetrance 2.44441528130431e-08 4.23703642756017e-07 0.664124002087428 0.955555555555556 27.2 27 2 muscular atrophy 3.96835677074911e-08 6.5157012985072e-07 0.663421968258583 0.954545454545455 27.2 27 2 lethality, incomplete penetrance 3.96835677074911e-08 6.5157012985072e-07 0.663421968258583 0.954545454545455 27.2 27 2 abnormal tail movements 0.000147397781523224 0.00110603915999704 0.663421968258583 0.954545454545455 27.2 27 2 increased skin papilloma incidence 0.000147397781523224 0.00110603915999704 0.663421968258583 0.954545454545455 27.2 27 2 abnormal vascular branching morphogenesis 0.000147397781523224 0.00110603915999704 0.663421968258583 0.954545454545455 27.2 27 2 prolonged PR interval 0.000147397781523224 0.00110603915999704 0.663421968258583 0.954545454545455 27.2 27 2 abnormal limb posture 0.000147397781523224 0.00110603915999704 0.663421968258583 0.954545454545455 27.2 27 2 cleft upper lip 0.000147397781523224 0.00110603915999704 0.663421968258583 0.954545454545455 27.2 27 2 abnormal occipital bone morphology 0.000147397781523224 0.00110603915999704 0.663421968258583 0.954545454545455 27.2 27 2 abnormal cerebral cortex pyramidal cell morphology 0.000147397781523224 0.00110603915999704 0.663421968258583 0.954545454545455 27.2 27 2 increased circulating creatine kinase level 0.000147397781523224 0.00110603915999704 0.663421968258583 0.954545454545455 27.2 27 2 cleft palate 6.25944901015222e-22 6.35525690316475e-20 0.663180811599819 0.954198473282443 27.2 27 2 short limbs 6.04411600709385e-15 2.94798795444038e-13 0.663058847312628 0.954022988505747 27.2 27 2 short snout 3.13668426017187e-18 2.40076987605463e-16 0.662836940067878 0.953703703703704 27.2 27 2 delayed endochondral bone ossification 6.4359013443557e-08 1.0295372729315e-06 0.662687281693512 0.953488372093023 27.2 27 2 gliosis 5.06317231574299e-11 1.42890962732779e-09 0.661917610053915 0.952380952380952 27.2 27 2 abnormal nervous system electrophysiology 2.57007297664653e-14 1.13151442998376e-12 0.661917610053915 0.952380952380952 27.2 27 2 abnormal scapula morphology 0.000239273060938594 0.00169329086510598 0.661917610053915 0.952380952380952 27.2 27 2 abnormal anxiety-related response 0.000239273060938594 0.00169329086510598 0.661917610053915 0.952380952380952 27.2 27 2 trunk curl 0.000239273060938594 0.00169329086510598 0.661917610053915 0.952380952380952 27.2 27 2 abnormal erythrocyte physiology 0.000239273060938594 0.00169329086510598 0.661917610053915 0.952380952380952 27.2 27 2 abnormal embryonic/fetal subventricular zone morphology 0.000239273060938594 0.00169329086510598 0.661917610053915 0.952380952380952 27.2 27 2 abnormal stapes morphology 0.000239273060938594 0.00169329086510598 0.661917610053915 0.952380952380952 27.2 27 2 decreased vocalization 0.000239273060938594 0.00169329086510598 0.661917610053915 0.952380952380952 27.2 27 2 increased muscle cell glucose uptake 0.000239273060938594 0.00169329086510598 0.661917610053915 0.952380952380952 27.2 27 2 pericardial effusion 8.192504055905e-11 2.20311933395283e-09 0.661383805529677 0.951612903225806 27.2 27 2 decreased cell proliferation 7.14940105449625e-30 1.14736355632641e-27 0.661202023448451 0.951351351351351 27.2 27 2 thick ventricular wall 1.68739099918179e-07 2.46905006497924e-06 0.661110393456288 0.951219512195122 27.2 27 2 abnormal cell differentiation 1.68739099918179e-07 2.46905006497924e-06 0.661110393456288 0.951219512195122 27.2 27 2 preweaning lethality, complete penetrance 2.04674437697837e-115 3.39418442515579e-112 0.66026281602878 0.95 27.2 27 2 abnormal posture 1.75591194493845e-13 6.87847395753449e-12 0.66026281602878 0.95 27.2 27 2 abnormal pericardium morphology 0.000387636227826473 0.00257819549924693 0.66026281602878 0.95 27.2 27 2 abnormal cell proliferation 0.000387636227826473 0.00257819549924693 0.66026281602878 0.95 27.2 27 2 anencephaly 0.000387636227826473 0.00257819549924693 0.66026281602878 0.95 27.2 27 2 decreased myocardial infarction size 0.000387636227826473 0.00257819549924693 0.66026281602878 0.95 27.2 27 2 abnormal hyoid bone morphology 0.000387636227826473 0.00257819549924693 0.66026281602878 0.95 27.2 27 2 spleen atrophy 0.000387636227826473 0.00257819549924693 0.66026281602878 0.95 27.2 27 2 abnormal heart right ventricle morphology 0.000387636227826473 0.00257819549924693 0.66026281602878 0.95 27.2 27 2 abnormal postnatal subventricular zone morphology 0.000387636227826473 0.00257819549924693 0.66026281602878 0.95 27.2 27 2 abnormal incus morphology 0.000387636227826473 0.00257819549924693 0.66026281602878 0.95 27.2 27 2 increased skin tumor incidence 0.000387636227826473 0.00257819549924693 0.66026281602878 0.95 27.2 27 2 decreased embryo size 1.46004386444728e-74 1.03767403223218e-71 0.660117415716948 0.949790794979079 27.2 27 2 abnormal CNS synaptic transmission 2.38005421958411e-16 1.37683369098034e-14 0.659911799114357 0.94949494949495 27.2 27 2 abnormal placenta labyrinth morphology 2.83438874280769e-13 1.06023187935852e-11 0.659822934072731 0.949367088607595 27.2 27 2 failure of heart looping 4.40372104548332e-07 6.05207519372362e-06 0.659371773092169 0.948717948717949 27.2 27 2 abnormal cell morphology 2.20707752769245e-18 1.74289058734444e-16 0.658433833158894 0.947368421052632 27.2 27 2 seizures 2.20707752769245e-18 1.74289058734444e-16 0.658433833158894 0.947368421052632 27.2 27 2 abnormal craniofacial bone morphology 8.97509416700821e-10 2.03886271602127e-08 0.658433833158894 0.947368421052632 27.2 27 2 increased hepatocellular carcinoma incidence 8.97509416700821e-10 2.03886271602127e-08 0.658433833158894 0.947368421052632 27.2 27 2 decreased hair follicle number 7.1008345089552e-07 9.39538608565216e-06 0.658433833158894 0.947368421052632 27.2 27 2 persistence of hyaloid vascular system 7.1008345089552e-07 9.39538608565216e-06 0.658433833158894 0.947368421052632 27.2 27 2 incomplete somite formation 7.1008345089552e-07 9.39538608565216e-06 0.658433833158894 0.947368421052632 27.2 27 2 decreased total retina thickness 7.1008345089552e-07 9.39538608565216e-06 0.658433833158894 0.947368421052632 27.2 27 2 kyphoscoliosis 0.000626614001864198 0.00390652212941652 0.658433833158894 0.947368421052632 27.2 27 2 abnormal stationary movement 0.000626614001864198 0.00390652212941652 0.658433833158894 0.947368421052632 27.2 27 2 unresponsive to tactile stimuli 0.000626614001864198 0.00390652212941652 0.658433833158894 0.947368421052632 27.2 27 2 delayed sexual maturation 0.000626614001864198 0.00390652212941652 0.658433833158894 0.947368421052632 27.2 27 2 decreased chemically-elicited antinociception 0.000626614001864198 0.00390652212941652 0.658433833158894 0.947368421052632 27.2 27 2 increased malignant tumor incidence 0.000626614001864198 0.00390652212941652 0.658433833158894 0.947368421052632 27.2 27 2 abnormal neurotransmitter level 0.000626614001864198 0.00390652212941652 0.658433833158894 0.947368421052632 27.2 27 2 abnormal nasal septum morphology 0.000626614001864198 0.00390652212941652 0.658433833158894 0.947368421052632 27.2 27 2 abnormal response to novelty 0.000626614001864198 0.00390652212941652 0.658433833158894 0.947368421052632 27.2 27 2 abnormal blastocyst morphology 0.000626614001864198 0.00390652212941652 0.658433833158894 0.947368421052632 27.2 27 2 abnormal limb morphology 1.91138991298214e-12 6.13494504328137e-11 0.657946104393591 0.946666666666667 27.2 27 2 impaired skeletal muscle contractility 1.14345927519991e-06 1.45120150360193e-05 0.657445193769767 0.945945945945946 27.2 27 2 increased erythroid progenitor cell number 1.14345927519991e-06 1.45120150360193e-05 0.657445193769767 0.945945945945946 27.2 27 2 abnormal locomotor behavior 6.69925454914806e-15 3.19383237139527e-13 0.657241018243751 0.945652173913043 27.2 27 2 astrocytosis 4.94225580592066e-12 1.52718774127051e-10 0.656930559567207 0.945205479452055 27.2 27 2 abnormal chondrocyte morphology 3.73328249679286e-09 7.86994933116291e-08 0.656401629970132 0.944444444444444 27.2 27 2 reduced long term depression 1.83875352828692e-06 2.22574180127188e-05 0.656401629970132 0.944444444444444 27.2 27 2 abnormal limb bone morphology 1.83875352828692e-06 2.22574180127188e-05 0.656401629970132 0.944444444444444 27.2 27 2 abnormal pharyngeal arch morphology 1.83875352828692e-06 2.22574180127188e-05 0.656401629970132 0.944444444444444 27.2 27 2 abnormal trophoblast giant cell morphology 1.83875352828692e-06 2.22574180127188e-05 0.656401629970132 0.944444444444444 27.2 27 2 underdeveloped hair follicles 0.00101047617518357 0.00600611585607917 0.656401629970132 0.944444444444444 27.2 27 2 abnormal mammary gland morphology 0.00101047617518357 0.00600611585607917 0.656401629970132 0.944444444444444 27.2 27 2 abnormal phrenic nerve morphology 0.00101047617518357 0.00600611585607917 0.656401629970132 0.944444444444444 27.2 27 2 abnormal thyroid cartilage morphology 0.00101047617518357 0.00600611585607917 0.656401629970132 0.944444444444444 27.2 27 2 abnormal body wall morphology 0.00101047617518357 0.00600611585607917 0.656401629970132 0.944444444444444 27.2 27 2 absent ureter 0.00101047617518357 0.00600611585607917 0.656401629970132 0.944444444444444 27.2 27 2 abnormal eye anterior chamber morphology 0.00101047617518357 0.00600611585607917 0.656401629970132 0.944444444444444 27.2 27 2 increased gastrointestinal tumor incidence 0.00101047617518357 0.00600611585607917 0.656401629970132 0.944444444444444 27.2 27 2 atrioventricular block 0.00101047617518357 0.00600611585607917 0.656401629970132 0.944444444444444 27.2 27 2 increased effector memory CD4-positive, alpha-beta T cell number 0.00101047617518357 0.00600611585607917 0.656401629970132 0.944444444444444 27.2 27 2 abnormal metanephric mesenchyme morphology 0.00101047617518357 0.00600611585607917 0.656401629970132 0.944444444444444 27.2 27 2 increased startle reflex 2.77528640711284e-14 1.21114472591109e-12 0.655967788839947 0.943820224719101 27.2 27 2 atrioventricular septal defect 5.99198245948129e-09 1.22172593179998e-07 0.655673104298689 0.943396226415094 27.2 27 2 abnormal erythropoiesis 1.57712419587246e-16 9.34070580293509e-15 0.655298433953376 0.942857142857143 27.2 27 2 embryonic lethality between somite formation and embryo turning, complete penetrance 2.04297531015805e-11 6.04988224287874e-10 0.655298433953376 0.942857142857143 27.2 27 2 thick pulmonary interalveolar septum 2.95246777355998e-06 3.43189887230394e-05 0.655298433953376 0.942857142857143 27.2 27 2 abnormal dermal layer morphology 2.95246777355998e-06 3.43189887230394e-05 0.655298433953376 0.942857142857143 27.2 27 2 holoprosencephaly 2.95246777355998e-06 3.43189887230394e-05 0.655298433953376 0.942857142857143 27.2 27 2 decreased glycogen level 2.95246777355998e-06 3.43189887230394e-05 0.655298433953376 0.942857142857143 27.2 27 2 increased red blood cell distribution width 2.95246777355998e-06 3.43189887230394e-05 0.655298433953376 0.942857142857143 27.2 27 2 abnormal eye morphology 2.0237168680509e-21 1.93615219587562e-19 0.655012714121697 0.942446043165468 27.2 27 2 distended pericardium 9.60700811457665e-09 1.88168761299287e-07 0.654916558409114 0.942307692307692 27.2 27 2 decreased spleen weight 3.27339313396693e-11 9.46809932644504e-10 0.654722853422894 0.942028985507246 27.2 27 2 abnormal inhibitory postsynaptic currents 5.2403588835787e-11 1.45646846065944e-09 0.65413034405328 0.941176470588235 27.2 27 2 small lung 1.53860240767896e-08 2.82455608051765e-07 0.65413034405328 0.941176470588235 27.2 27 2 failure of chorioallantoic fusion 1.53860240767896e-08 2.82455608051765e-07 0.65413034405328 0.941176470588235 27.2 27 2 abnormal dendritic spine morphology 1.53860240767896e-08 2.82455608051765e-07 0.65413034405328 0.941176470588235 27.2 27 2 enlarged liver sinusoidal spaces 4.73336750891597e-06 5.23576502381068e-05 0.65413034405328 0.941176470588235 27.2 27 2 abnormal brown adipose tissue morphology 4.73336750891597e-06 5.23576502381068e-05 0.65413034405328 0.941176470588235 27.2 27 2 abnormal bone marrow cavity morphology 0.00162514576554714 0.00897347412163934 0.65413034405328 0.941176470588235 27.2 27 2 hyperlipidemia 0.00162514576554714 0.00897347412163934 0.65413034405328 0.941176470588235 27.2 27 2 abnormal glutamate-mediated receptor currents 0.00162514576554714 0.00897347412163934 0.65413034405328 0.941176470588235 27.2 27 2 decreased vasoconstriction 0.00162514576554714 0.00897347412163934 0.65413034405328 0.941176470588235 27.2 27 2 absence seizures 0.00162514576554714 0.00897347412163934 0.65413034405328 0.941176470588235 27.2 27 2 abnormal melanosome morphology 0.00162514576554714 0.00897347412163934 0.65413034405328 0.941176470588235 27.2 27 2 increased brain size 0.00162514576554714 0.00897347412163934 0.65413034405328 0.941176470588235 27.2 27 2 increased trabecular bone mass 0.00162514576554714 0.00897347412163934 0.65413034405328 0.941176470588235 27.2 27 2 abnormal ductus venosus valve morphology 0.00162514576554714 0.00897347412163934 0.65413034405328 0.941176470588235 27.2 27 2 abnormal cell cytoskeleton morphology 0.00162514576554714 0.00897347412163934 0.65413034405328 0.941176470588235 27.2 27 2 kyphosis 1.22741416540736e-22 1.3274751028047e-20 0.653312681123214 0.94 27.2 27 2 abnormal interventricular septum morphology 2.46131362324601e-08 4.23703642756017e-07 0.653312681123214 0.94 27.2 27 2 increased B cell derived lymphoma incidence 2.46131362324601e-08 4.23703642756017e-07 0.653312681123214 0.94 27.2 27 2 short tail 4.67724141151916e-13 1.68617942190636e-11 0.653145207992959 0.939759036144578 27.2 27 2 abnormal neuron morphology 2.64768962455652e-15 1.41637160023319e-13 0.652891460825907 0.939393939393939 27.2 27 2 dilated heart atrium 7.57600455187145e-06 7.86860598028402e-05 0.652891460825907 0.939393939393939 27.2 27 2 abnormal middle ear ossicle morphology 7.57600455187145e-06 7.86860598028402e-05 0.652891460825907 0.939393939393939 27.2 27 2 impaired coordination 2.42123962736341e-50 1.09506064964845e-47 0.652830590840747 0.939306358381503 27.2 27 2 embryonic lethality during organogenesis, complete penetrance 6.77228272093016e-81 5.61535108943792e-78 0.652816242915673 0.939285714285714 27.2 27 2 abnormal cell cycle 1.51230426006408e-17 9.77105674521922e-16 0.652708321566208 0.939130434782609 27.2 27 2 abnormal excitatory postsynaptic potential 7.47026587402342e-13 2.5989211694592e-11 0.652634619181207 0.939024390243902 27.2 27 2 abnormal embryonic tissue morphology 5.00765635477189e-22 5.30065752446599e-20 0.652461644196002 0.938775510204082 27.2 27 2 absent kidney 3.93269606180523e-08 6.50005412208672e-07 0.652461644196002 0.938775510204082 27.2 27 2 abnormal spatial learning 2.89243883554543e-24 3.42616266829489e-22 0.652374626105285 0.938650306748466 27.2 27 2 lethality throughout fetal growth and development, incomplete penetrance 1.67221904032588e-26 2.31091381267258e-24 0.652303164321288 0.93854748603352 27.2 27 2 abnormal neural tube morphology 4.61805300280039e-24 5.22154856566635e-22 0.652111423238301 0.938271604938272 27.2 27 2 increased neuron apoptosis 1.19219674337525e-12 3.98065691160529e-11 0.652111423238301 0.938271604938272 27.2 27 2 neonatal lethality 1.21046792684734e-05 0.00011761870968878 0.651575147396822 0.9375 27.2 27 2 abnormal diaphragm morphology 1.21046792684734e-05 0.00011761870968878 0.651575147396822 0.9375 27.2 27 2 abnormal heart atrium morphology 1.21046792684734e-05 0.00011761870968878 0.651575147396822 0.9375 27.2 27 2 abnormal depression-related behavior 1.21046792684734e-05 0.00011761870968878 0.651575147396822 0.9375 27.2 27 2 abnormal embryonic hematopoiesis 1.21046792684734e-05 0.00011761870968878 0.651575147396822 0.9375 27.2 27 2 bradykinesia 1.21046792684734e-05 0.00011761870968878 0.651575147396822 0.9375 27.2 27 2 increased fatty acid level 1.21046792684734e-05 0.00011761870968878 0.651575147396822 0.9375 27.2 27 2 increased fibroblast apoptosis 1.21046792684734e-05 0.00011761870968878 0.651575147396822 0.9375 27.2 27 2 abnormal tympanic ring morphology 0.00260597606826029 0.0134417054979315 0.651575147396822 0.9375 27.2 27 2 failure of tooth eruption 0.00260597606826029 0.0134417054979315 0.651575147396822 0.9375 27.2 27 2 abnormal bone marrow cell number 0.00260597606826029 0.0134417054979315 0.651575147396822 0.9375 27.2 27 2 vasculature congestion 0.00260597606826029 0.0134417054979315 0.651575147396822 0.9375 27.2 27 2 abnormal hair follicle orientation 0.00260597606826029 0.0134417054979315 0.651575147396822 0.9375 27.2 27 2 disorganized retinal layers 0.00260597606826029 0.0134417054979315 0.651575147396822 0.9375 27.2 27 2 poor circulation 0.00260597606826029 0.0134417054979315 0.651575147396822 0.9375 27.2 27 2 disorganized yolk sac vascular plexus 0.00260597606826029 0.0134417054979315 0.651575147396822 0.9375 27.2 27 2 white spotting 0.00260597606826029 0.0134417054979315 0.651575147396822 0.9375 27.2 27 2 abnormal epicardium morphology 0.00260597606826029 0.0134417054979315 0.651575147396822 0.9375 27.2 27 2 decreased cochlear coiling 0.00260597606826029 0.0134417054979315 0.651575147396822 0.9375 27.2 27 2 decreased aggression towards mice 0.00260597606826029 0.0134417054979315 0.651575147396822 0.9375 27.2 27 2 abnormal amnion morphology 0.00260597606826029 0.0134417054979315 0.651575147396822 0.9375 27.2 27 2 abnormal thoracic cage shape 0.00260597606826029 0.0134417054979315 0.651575147396822 0.9375 27.2 27 2 increased heart left ventricle size 0.00260597606826029 0.0134417054979315 0.651575147396822 0.9375 27.2 27 2 dilated respiratory conducting tubes 0.00260597606826029 0.0134417054979315 0.651575147396822 0.9375 27.2 27 2 decreased fibroblast apoptosis 0.00260597606826029 0.0134417054979315 0.651575147396822 0.9375 27.2 27 2 abnormal heart ventricle morphology 4.82274964769336e-12 1.49957371857966e-10 0.650461343726058 0.935897435897436 27.2 27 2 abnormal eyelid morphology 1.93047282190177e-05 0.000180528238514311 0.6501739105207 0.935483870967742 27.2 27 2 abnormal object recognition memory 1.93047282190177e-05 0.000180528238514311 0.6501739105207 0.935483870967742 27.2 27 2 abnormal postnatal growth/weight/body size 1.93047282190177e-05 0.000180528238514311 0.6501739105207 0.935483870967742 27.2 27 2 pale kidney 1.93047282190177e-05 0.000180528238514311 0.6501739105207 0.935483870967742 27.2 27 2 abnormal podocyte morphology 1.93047282190177e-05 0.000180528238514311 0.6501739105207 0.935483870967742 27.2 27 2 decreased anxiety-related response 3.61143830738106e-18 2.68162769839116e-16 0.649809361089514 0.934959349593496 27.2 27 2 abnormal forelimb morphology 1.59200902247167e-07 2.34647094866408e-06 0.649686523781179 0.934782608695652 27.2 27 2 abnormal allantois morphology 1.59200902247167e-07 2.34647094866408e-06 0.649686523781179 0.934782608695652 27.2 27 2 embryonic lethality between implantation and placentation, complete penetrance 1.59200902247167e-07 2.34647094866408e-06 0.649686523781179 0.934782608695652 27.2 27 2 embryonic lethality between implantation and somite formation, complete penetrance 7.40087754993656e-35 1.92857001018083e-32 0.649624854438628 0.93469387755102 27.2 27 2 perinatal lethality, complete penetrance 2.21047886744386e-30 3.80162909533762e-28 0.64933185267965 0.934272300469484 27.2 27 2 irregular heartbeat 2.53035376229762e-07 3.60702291330391e-06 0.648679257852836 0.933333333333333 27.2 27 2 abnormal ectoderm development 2.53035376229762e-07 3.60702291330391e-06 0.648679257852836 0.933333333333333 27.2 27 2 abnormal cell migration 2.53035376229762e-07 3.60702291330391e-06 0.648679257852836 0.933333333333333 27.2 27 2 abnormal response to new environment 3.07270892158175e-05 0.000272797451368219 0.648679257852836 0.933333333333333 27.2 27 2 abnormal brain vasculature morphology 3.07270892158175e-05 0.000272797451368219 0.648679257852836 0.933333333333333 27.2 27 2 abnormal fontanelle morphology 0.00416494453252892 0.0197904479936307 0.648679257852836 0.933333333333333 27.2 27 2 decreased salivation 0.00416494453252892 0.0197904479936307 0.648679257852836 0.933333333333333 27.2 27 2 abnormal enteric neuron morphology 0.00416494453252892 0.0197904479936307 0.648679257852836 0.933333333333333 27.2 27 2 abnormal prostate gland morphology 0.00416494453252892 0.0197904479936307 0.648679257852836 0.933333333333333 27.2 27 2 hyperpigmentation 0.00416494453252892 0.0197904479936307 0.648679257852836 0.933333333333333 27.2 27 2 audiogenic seizures 0.00416494453252892 0.0197904479936307 0.648679257852836 0.933333333333333 27.2 27 2 abnormal apical ectodermal ridge morphology 0.00416494453252892 0.0197904479936307 0.648679257852836 0.933333333333333 27.2 27 2 abnormal cricoid cartilage morphology 0.00416494453252892 0.0197904479936307 0.648679257852836 0.933333333333333 27.2 27 2 decreased aggression towards males 0.00416494453252892 0.0197904479936307 0.648679257852836 0.933333333333333 27.2 27 2 abnormal ear development 0.00416494453252892 0.0197904479936307 0.648679257852836 0.933333333333333 27.2 27 2 abnormal neurotransmitter secretion 0.00416494453252892 0.0197904479936307 0.648679257852836 0.933333333333333 27.2 27 2 abnormal cerebral aqueduct morphology 0.00416494453252892 0.0197904479936307 0.648679257852836 0.933333333333333 27.2 27 2 abnormal secondary palate development 0.00416494453252892 0.0197904479936307 0.648679257852836 0.933333333333333 27.2 27 2 ostium primum atrial septal defect 0.00416494453252892 0.0197904479936307 0.648679257852836 0.933333333333333 27.2 27 2 herniated liver 0.00416494453252892 0.0197904479936307 0.648679257852836 0.933333333333333 27.2 27 2 abnormal branching involved in lung morphogenesis 0.00416494453252892 0.0197904479936307 0.648679257852836 0.933333333333333 27.2 27 2 decreased rib number 2.76390568700475e-13 1.04169930248853e-11 0.648158648496614 0.932584269662921 27.2 27 2 abnormal craniofacial morphology 3.9827355881722e-15 2.02184791338334e-13 0.647779564013928 0.932038834951456 27.2 27 2 abnormal motor capabilities/coordination/movement 5.30791108322194e-19 4.55290648948778e-17 0.647626207109569 0.931818181818182 27.2 27 2 small kidney 4.38140443865261e-13 1.59105745126254e-11 0.647626207109569 0.931818181818182 27.2 27 2 omphalocele 4.01590105169793e-07 5.58075634977575e-06 0.647626207109569 0.931818181818182 27.2 27 2 kinked tail 6.31032700420239e-15 3.04794920834047e-13 0.647316486302725 0.931372549019608 27.2 27 2 abnormal embryonic neuroepithelium morphology 5.49419036002787e-09 1.14847046391339e-07 0.647081525690637 0.931034482758621 27.2 27 2 increased mortality induced by gamma-irradiation 4.88058172248817e-05 0.000416481887982481 0.647081525690637 0.931034482758621 27.2 27 2 decreased trophoblast giant cell number 4.88058172248817e-05 0.000416481887982481 0.647081525690637 0.931034482758621 27.2 27 2 absent long term depression 4.88058172248817e-05 0.000416481887982481 0.647081525690637 0.931034482758621 27.2 27 2 embryonic lethality, complete penetrance 7.27477814766073e-44 2.5851443774723e-41 0.647081525690637 0.931034482758621 27.2 27 2 edema 4.16650132882212e-24 4.82054514206745e-22 0.646524177261963 0.930232558139535 27.2 27 2 abnormal axon guidance 6.36388983343253e-07 8.60335650036056e-06 0.646524177261963 0.930232558139535 27.2 27 2 absent vitelline blood vessels 8.69650713763942e-09 1.71686996070461e-07 0.646240614026322 0.929824561403509 27.2 27 2 decreased brain weight 8.69650713763942e-09 1.71686996070461e-07 0.646240614026322 0.929824561403509 27.2 27 2 abnormal lung development 1.73677288212918e-12 5.68450334775834e-11 0.645953714752614 0.929411764705882 27.2 27 2 cardiac fibrosis 1.73677288212918e-12 5.68450334775834e-11 0.645953714752614 0.929411764705882 27.2 27 2 abnormal motor coordination/ balance 2.49912234867761e-14 1.11010122184563e-12 0.645871122537456 0.929292929292929 27.2 27 2 short mandible 1.37482121335271e-08 2.59864319444155e-07 0.645369669802567 0.928571428571429 27.2 27 2 enhanced long term potentiation 1.37482121335271e-08 2.59864319444155e-07 0.645369669802567 0.928571428571429 27.2 27 2 abnormal cartilage morphology 1.0068623444118e-06 1.29435146342344e-05 0.645369669802567 0.928571428571429 27.2 27 2 abnormal optic nerve morphology 1.0068623444118e-06 1.29435146342344e-05 0.645369669802567 0.928571428571429 27.2 27 2 myoclonus 7.73488380691385e-05 0.000626727148850104 0.645369669802567 0.928571428571429 27.2 27 2 abnormal jaw morphology 7.73488380691385e-05 0.000626727148850104 0.645369669802567 0.928571428571429 27.2 27 2 absent corpus callosum 7.73488380691385e-05 0.000626727148850104 0.645369669802567 0.928571428571429 27.2 27 2 premature aging 7.73488380691385e-05 0.000626727148850104 0.645369669802567 0.928571428571429 27.2 27 2 abnormal brainstem morphology 7.73488380691385e-05 0.000626727148850104 0.645369669802567 0.928571428571429 27.2 27 2 abnormal vasoconstriction 0.00663176406878005 0.0284177659278042 0.645369669802567 0.928571428571429 27.2 27 2 absent atrioventricular cushions 0.00663176406878005 0.0284177659278042 0.645369669802567 0.928571428571429 27.2 27 2 abnormal placing response 0.00663176406878005 0.0284177659278042 0.645369669802567 0.928571428571429 27.2 27 2 decreased coping response 0.00663176406878005 0.0284177659278042 0.645369669802567 0.928571428571429 27.2 27 2 amyloid beta deposits 0.00663176406878005 0.0284177659278042 0.645369669802567 0.928571428571429 27.2 27 2 abnormal ventral body wall morphology 0.00663176406878005 0.0284177659278042 0.645369669802567 0.928571428571429 27.2 27 2 absent olfactory bulb 0.00663176406878005 0.0284177659278042 0.645369669802567 0.928571428571429 27.2 27 2 abnormal voluntary movement 0.00663176406878005 0.0284177659278042 0.645369669802567 0.928571428571429 27.2 27 2 abnormal vascular endothelial cell migration 0.00663176406878005 0.0284177659278042 0.645369669802567 0.928571428571429 27.2 27 2 abnormal maternal decidual layer morphology 0.00663176406878005 0.0284177659278042 0.645369669802567 0.928571428571429 27.2 27 2 split sternum 0.00663176406878005 0.0284177659278042 0.645369669802567 0.928571428571429 27.2 27 2 decreased CNS synapse formation 0.00663176406878005 0.0284177659278042 0.645369669802567 0.928571428571429 27.2 27 2 premature hair loss 0.00663176406878005 0.0284177659278042 0.645369669802567 0.928571428571429 27.2 27 2 abnormal viscerocranium morphology 0.00663176406878005 0.0284177659278042 0.645369669802567 0.928571428571429 27.2 27 2 decreased cornea thickness 0.00663176406878005 0.0284177659278042 0.645369669802567 0.928571428571429 27.2 27 2 increased pulmonary respiratory rate 0.00663176406878005 0.0284177659278042 0.645369669802567 0.928571428571429 27.2 27 2 decreased tongue size 0.00663176406878005 0.0284177659278042 0.645369669802567 0.928571428571429 27.2 27 2 pulmonary alveolar hemorrhage 0.00663176406878005 0.0284177659278042 0.645369669802567 0.928571428571429 27.2 27 2 decreased response to antigen 0.00663176406878005 0.0284177659278042 0.645369669802567 0.928571428571429 27.2 27 2 embryonic lethality before implantation, complete penetrance 1.31462886804748e-17 8.83821434937328e-16 0.644972519236534 0.928 27.2 27 2 pale yolk sac 4.33140798094962e-12 1.36384523450787e-10 0.644771551480229 0.927710843373494 27.2 27 2 hemopericardium 1.59035152949254e-06 1.96815892020532e-05 0.644158844906127 0.926829268292683 27.2 27 2 palatal shelves fail to meet at midline 1.59035152949254e-06 1.96815892020532e-05 0.644158844906127 0.926829268292683 27.2 27 2 lethality throughout fetal growth and development, complete penetrance 8.66625279368597e-26 1.16525966617805e-23 0.643801970199807 0.926315789473684 27.2 27 2 abnormal axon morphology 3.53823479463051e-15 1.81471320652441e-13 0.643531009774639 0.925925925925926 27.2 27 2 neurodegeneration 3.42257319930866e-08 5.7719666666307e-07 0.643531009774639 0.925925925925926 27.2 27 2 abnormal long bone epiphyseal plate proliferative zone 3.42257319930866e-08 5.7719666666307e-07 0.643531009774639 0.925925925925926 27.2 27 2 abnormal neuronal precursor proliferation 3.42257319930866e-08 5.7719666666307e-07 0.643531009774639 0.925925925925926 27.2 27 2 abnormal trigeminal nerve morphology 0.000122292932496002 0.00095963302707825 0.643531009774639 0.925925925925926 27.2 27 2 abnormal trigeminal ganglion morphology 0.000122292932496002 0.00095963302707825 0.643531009774639 0.925925925925926 27.2 27 2 abnormal fetal cardiomyocyte proliferation 0.000122292932496002 0.00095963302707825 0.643531009774639 0.925925925925926 27.2 27 2 thick interventricular septum 0.000122292932496002 0.00095963302707825 0.643531009774639 0.925925925925926 27.2 27 2 embryonic growth arrest 1.07319701283405e-30 1.97746486624052e-28 0.64341860261136 0.925764192139738 27.2 27 2 pallor 9.29999183025399e-24 1.02816576345586e-21 0.643383916972405 0.925714285714286 27.2 27 2 cleft secondary palate 2.43993389211767e-13 9.26616115517972e-12 0.643257166791756 0.925531914893617 27.2 27 2 rib fusion 7.55512639647692e-10 1.75639036553611e-08 0.643146812156863 0.925373134328358 27.2 27 2 enlarged kidney 5.38910723894957e-08 8.73316238233684e-07 0.642559642212715 0.924528301886792 27.2 27 2 abnormal heart development 2.46644503388582e-21 2.31520076293999e-19 0.642227655830792 0.924050632911392 27.2 27 2 abnormal nervous system morphology 2.66436028487948e-11 7.75157451302657e-10 0.642227655830792 0.924050632911392 27.2 27 2 decreased cardiac muscle contractility 2.16323439004562e-14 9.69557755898823e-13 0.641550914359948 0.923076923076923 27.2 27 2 abnormal locomotor activation 9.480736432382e-13 3.19155535190209e-11 0.641550914359948 0.923076923076923 27.2 27 2 abnormal snout morphology 8.4734215623344e-08 1.32148188942362e-06 0.641550914359948 0.923076923076923 27.2 27 2 liver hypoplasia 8.4734215623344e-08 1.32148188942362e-06 0.641550914359948 0.923076923076923 27.2 27 2 eyelids open at birth 8.4734215623344e-08 1.32148188942362e-06 0.641550914359948 0.923076923076923 27.2 27 2 kinked neural tube 8.4734215623344e-08 1.32148188942362e-06 0.641550914359948 0.923076923076923 27.2 27 2 decreased kidney weight 8.4734215623344e-08 1.32148188942362e-06 0.641550914359948 0.923076923076923 27.2 27 2 abnormal heart looping 3.94661960706172e-06 4.46237103298456e-05 0.641550914359948 0.923076923076923 27.2 27 2 no spontaneous movement 0.000192859232719603 0.0014277897065179 0.641550914359948 0.923076923076923 27.2 27 2 heart inflammation 0.000192859232719603 0.0014277897065179 0.641550914359948 0.923076923076923 27.2 27 2 abnormal erythrocyte osmotic lysis 0.000192859232719603 0.0014277897065179 0.641550914359948 0.923076923076923 27.2 27 2 decreased bone resorption 0.000192859232719603 0.0014277897065179 0.641550914359948 0.923076923076923 27.2 27 2 abnormal nerve conduction 0.000192859232719603 0.0014277897065179 0.641550914359948 0.923076923076923 27.2 27 2 short premaxilla 0.0105151187910421 0.0418167194128172 0.641550914359948 0.923076923076923 27.2 27 2 short hair 0.0105151187910421 0.0418167194128172 0.641550914359948 0.923076923076923 27.2 27 2 tight skin 0.0105151187910421 0.0418167194128172 0.641550914359948 0.923076923076923 27.2 27 2 dystrophic cardiac calcinosis 0.0105151187910421 0.0418167194128172 0.641550914359948 0.923076923076923 27.2 27 2 abnormal tail bud morphology 0.0105151187910421 0.0418167194128172 0.641550914359948 0.923076923076923 27.2 27 2 increased synaptic depression 0.0105151187910421 0.0418167194128172 0.641550914359948 0.923076923076923 27.2 27 2 anal atresia 0.0105151187910421 0.0418167194128172 0.641550914359948 0.923076923076923 27.2 27 2 tracheoesophageal fistula 0.0105151187910421 0.0418167194128172 0.641550914359948 0.923076923076923 27.2 27 2 muscle fatigue 0.0105151187910421 0.0418167194128172 0.641550914359948 0.923076923076923 27.2 27 2 small interparietal bone 0.0105151187910421 0.0418167194128172 0.641550914359948 0.923076923076923 27.2 27 2 abnormal vertebral arch development 0.0105151187910421 0.0418167194128172 0.641550914359948 0.923076923076923 27.2 27 2 abnormal aorta tunica media morphology 0.0105151187910421 0.0418167194128172 0.641550914359948 0.923076923076923 27.2 27 2 decreased cardiac stroke volume 0.0105151187910421 0.0418167194128172 0.641550914359948 0.923076923076923 27.2 27 2 decreased grip strength 9.98699510186938e-29 1.55266564474375e-26 0.641062671654956 0.922374429223744 27.2 27 2 decreased circulating LDL cholesterol level 2.93195401118923e-09 6.31448969942269e-08 0.640715561606875 0.921875 27.2 27 2 hydroencephaly 1.22132788460287e-15 6.98403014471181e-14 0.640621130426093 0.921739130434783 27.2 27 2 anophthalmia 2.33292469579556e-12 7.39254800100821e-11 0.640349508153282 0.921348314606742 27.2 27 2 abnormal axial skeleton morphology 1.02988541723076e-10 2.73993580252569e-09 0.640144004460036 0.921052631578947 27.2 27 2 increased grooming behavior 6.19951055875114e-06 6.60440364663531e-05 0.640144004460036 0.921052631578947 27.2 27 2 impaired branching involved in ureteric bud morphogenesis 6.19951055875114e-06 6.60440364663531e-05 0.640144004460036 0.921052631578947 27.2 27 2 prenatal lethality, complete penetrance 9.8426814806493e-36 2.7204077981239e-33 0.640012422958605 0.920863309352518 27.2 27 2 abnormal embryo size 2.99782360740785e-15 1.56991288914253e-13 0.639658433786615 0.920353982300885 27.2 27 2 mandible hypoplasia 0.000303311541411424 0.00209871337763816 0.639412411312082 0.92 27.2 27 2 spontaneous skin ulceration 0.000303311541411424 0.00209871337763816 0.639412411312082 0.92 27.2 27 2 increased cellular sensitivity to ionizing radiation 0.000303311541411424 0.00209871337763816 0.639412411312082 0.92 27.2 27 2 abnormal vertebrae development 0.000303311541411424 0.00209871337763816 0.639412411312082 0.92 27.2 27 2 abnormal energy expenditure 0.000303311541411424 0.00209871337763816 0.639412411312082 0.92 27.2 27 2 delayed bone ossification 1.61286921930324e-10 4.17917935730917e-09 0.639412411312081 0.92 27.2 27 2 reduced long term potentiation 4.69142484067024e-15 2.31087510716183e-13 0.639164192208311 0.919642857142857 27.2 27 2 abnormal coat/hair pigmentation 4.69142484067024e-15 2.31087510716183e-13 0.639164192208311 0.919642857142857 27.2 27 2 abnormal gait 4.39882649153901e-39 1.45894411969377e-36 0.638782625624846 0.919093851132686 27.2 27 2 malocclusion 9.718755063273e-06 9.80746580928665e-05 0.638661045376345 0.918918918918919 27.2 27 2 abnormal breathing pattern 9.718755063273e-06 9.80746580928665e-05 0.638661045376345 0.918918918918919 27.2 27 2 abnormal chromosome morphology 9.718755063273e-06 9.80746580928665e-05 0.638661045376345 0.918918918918919 27.2 27 2 abnormal humerus morphology 9.718755063273e-06 9.80746580928665e-05 0.638661045376345 0.918918918918919 27.2 27 2 abnormal respiratory electron transport chain 9.718755063273e-06 9.80746580928665e-05 0.638661045376345 0.918918918918919 27.2 27 2 abnormal long bone hypertrophic chondrocyte zone 3.26369587300027e-07 4.58669123394812e-06 0.638277695409132 0.918367346938776 27.2 27 2 abnormal long bone morphology 1.12507280150183e-08 2.14453532087034e-07 0.638045171658528 0.918032786885246 27.2 27 2 abnormal cranium morphology 1.49303263344986e-17 9.77105674521922e-16 0.637960144316889 0.917910447761194 27.2 27 2 abnormal behavior 7.75304526705863e-35 1.92857001018083e-32 0.637512374431423 0.91726618705036 27.2 27 2 preweaning lethality, incomplete penetrance 1.56515969177084e-50 7.78666946655994e-48 0.637237307967552 0.916870415647922 27.2 27 2 increased susceptibility to pharmacologically induced seizures 7.77884314891433e-13 2.68748226846172e-11 0.637095699676893 0.916666666666667 27.2 27 2 abnormal neuromuscular synapse morphology 6.15305750374967e-10 1.44393684345069e-08 0.637095699676893 0.916666666666667 27.2 27 2 absent mesoderm 1.75665470526662e-08 3.14365365420914e-07 0.637095699676893 0.916666666666667 27.2 27 2 intracranial hemorrhage 1.75665470526662e-08 3.14365365420914e-07 0.637095699676893 0.916666666666667 27.2 27 2 abnormal long bone epiphyseal plate morphology 1.75665470526662e-08 3.14365365420914e-07 0.637095699676893 0.916666666666667 27.2 27 2 increased erythrocyte cell number 1.75665470526662e-08 3.14365365420914e-07 0.637095699676893 0.916666666666667 27.2 27 2 small heart 5.09933366130288e-07 6.95046163424159e-06 0.637095699676893 0.916666666666667 27.2 27 2 thymus atrophy 5.09933366130288e-07 6.95046163424159e-06 0.637095699676893 0.916666666666667 27.2 27 2 abnormal phalanx morphology 5.09933366130288e-07 6.95046163424159e-06 0.637095699676893 0.916666666666667 27.2 27 2 heart right ventricle hypertrophy 1.52033244715636e-05 0.00014545488316544 0.637095699676893 0.916666666666667 27.2 27 2 decreased body height 0.000475614712047499 0.00310595134562773 0.637095699676893 0.916666666666667 27.2 27 2 abnormal body weight 0.000475614712047499 0.00310595134562773 0.637095699676893 0.916666666666667 27.2 27 2 ocular hypertelorism 0.000475614712047499 0.00310595134562773 0.637095699676893 0.916666666666667 27.2 27 2 abnormal sensory capabilities/reflexes/nociception 0.000475614712047499 0.00310595134562773 0.637095699676893 0.916666666666667 27.2 27 2 prolonged QT interval 0.000475614712047499 0.00310595134562773 0.637095699676893 0.916666666666667 27.2 27 2 abnormal truncus arteriosus septation 0.000475614712047499 0.00310595134562773 0.637095699676893 0.916666666666667 27.2 27 2 abnormal supraoccipital bone morphology 0.0165921353302517 0.0597292860115789 0.637095699676893 0.916666666666667 27.2 27 2 abnormal superior cervical ganglion morphology 0.0165921353302517 0.0597292860115789 0.637095699676893 0.916666666666667 27.2 27 2 abnormal enteric nervous system morphology 0.0165921353302517 0.0597292860115789 0.637095699676893 0.916666666666667 27.2 27 2 absent optic nerve 0.0165921353302517 0.0597292860115789 0.637095699676893 0.916666666666667 27.2 27 2 abnormal mating frequency 0.0165921353302517 0.0597292860115789 0.637095699676893 0.916666666666667 27.2 27 2 impaired embryo implantation 0.0165921353302517 0.0597292860115789 0.637095699676893 0.916666666666667 27.2 27 2 abnormal thymus involution 0.0165921353302517 0.0597292860115789 0.637095699676893 0.916666666666667 27.2 27 2 increased papilloma incidence 0.0165921353302517 0.0597292860115789 0.637095699676893 0.916666666666667 27.2 27 2 altered tumor susceptibility 0.0165921353302517 0.0597292860115789 0.637095699676893 0.916666666666667 27.2 27 2 increased growth rate 0.0165921353302517 0.0597292860115789 0.637095699676893 0.916666666666667 27.2 27 2 decreased synaptic depression 0.0165921353302517 0.0597292860115789 0.637095699676893 0.916666666666667 27.2 27 2 abnormal aorta elastic fiber morphology 0.0165921353302517 0.0597292860115789 0.637095699676893 0.916666666666667 27.2 27 2 abnormal alisphenoid bone morphology 0.0165921353302517 0.0597292860115789 0.637095699676893 0.916666666666667 27.2 27 2 abnormal vascular endothelial cell development 0.0165921353302517 0.0597292860115789 0.637095699676893 0.916666666666667 27.2 27 2 small parietal bone 0.0165921353302517 0.0597292860115789 0.637095699676893 0.916666666666667 27.2 27 2 abnormal cochlear outer hair cell physiology 0.0165921353302517 0.0597292860115789 0.637095699676893 0.916666666666667 27.2 27 2 abnormal B cell proliferation 0.0165921353302517 0.0597292860115789 0.637095699676893 0.916666666666667 27.2 27 2 hematuria 0.0165921353302517 0.0597292860115789 0.637095699676893 0.916666666666667 27.2 27 2 abnormal somatic nervous system physiology 0.0165921353302517 0.0597292860115789 0.637095699676893 0.916666666666667 27.2 27 2 decreased renal glomerular filtration rate 0.0165921353302517 0.0597292860115789 0.637095699676893 0.916666666666667 27.2 27 2 decreased prostaglandin level 0.0165921353302517 0.0597292860115789 0.637095699676893 0.916666666666667 27.2 27 2 decreased mammary gland epithelial cell proliferation 0.0165921353302517 0.0597292860115789 0.637095699676893 0.916666666666667 27.2 27 2 increased fibrosarcoma incidence 0.0165921353302517 0.0597292860115789 0.637095699676893 0.916666666666667 27.2 27 2 prenatal growth retardation 0.0165921353302517 0.0597292860115789 0.637095699676893 0.916666666666667 27.2 27 2 abnormal colon goblet cell morphology 0.0165921353302517 0.0597292860115789 0.637095699676893 0.916666666666667 27.2 27 2 abnormal neural tube closure 3.39696495896376e-11 9.76872871147092e-10 0.636397894967499 0.91566265060241 27.2 27 2 syndactyly 2.73889746361663e-08 4.69862582120438e-07 0.636114042204355 0.915254237288136 27.2 27 2 abnormal cell nucleus morphology 7.9535753237215e-07 1.04679992686546e-05 0.63586340625392 0.914893617021277 27.2 27 2 abnormal liver development 2.37296313527134e-05 0.000217675675528614 0.635440905651758 0.914285714285714 27.2 27 2 abnormal midbrain development 2.37296313527134e-05 0.000217675675528614 0.635440905651758 0.914285714285714 27.2 27 2 abnormal embryonic epiblast morphology 2.37296313527134e-05 0.000217675675528614 0.635440905651758 0.914285714285714 27.2 27 2 decreased bone mineralization 2.37296313527134e-05 0.000217675675528614 0.635440905651758 0.914285714285714 27.2 27 2 hyperactivity 6.31710283535402e-45 2.41750666199125e-42 0.635066235306444 0.913746630727763 27.2 27 2 abnormal heart morphology 2.15731123132426e-28 3.25231011389036e-26 0.634839162369891 0.913419913419913 27.2 27 2 microcephaly 2.32212767221e-09 5.04479701713745e-08 0.634577534856036 0.91304347826087 27.2 27 2 abnormal sleep pattern 1.23829735304699e-06 1.56358612472304e-05 0.634577534856036 0.91304347826087 27.2 27 2 abnormal myelin sheath morphology 1.23829735304699e-06 1.56358612472304e-05 0.634577534856036 0.91304347826087 27.2 27 2 abnormal innervation pattern to muscle 0.000743424496847983 0.00454924584479547 0.634577534856036 0.91304347826087 27.2 27 2 blistering 0.000743424496847983 0.00454924584479547 0.634577534856036 0.91304347826087 27.2 27 2 abnormal nasal cavity morphology 0.000743424496847983 0.00454924584479547 0.634577534856036 0.91304347826087 27.2 27 2 abnormal sacral vertebrae morphology 0.000743424496847983 0.00454924584479547 0.634577534856036 0.91304347826087 27.2 27 2 dilated heart 0.000743424496847983 0.00454924584479547 0.634577534856036 0.91304347826087 27.2 27 2 abnormal palatal shelf fusion at midline 0.000743424496847983 0.00454924584479547 0.634577534856036 0.91304347826087 27.2 27 2 abnormal vertebral artery topology 0.000743424496847983 0.00454924584479547 0.634577534856036 0.91304347826087 27.2 27 2 ventricular septal defect 4.51383250752418e-17 2.7723847808559e-15 0.633688770801615 0.911764705882353 27.2 27 2 abnormal nervous system development 3.69499206624113e-05 0.000324207857664015 0.633688770801615 0.911764705882353 27.2 27 2 abnormal direction of heart looping 3.69499206624113e-05 0.000324207857664015 0.633688770801615 0.911764705882353 27.2 27 2 neonatal lethality, incomplete penetrance 2.27059286266837e-31 4.51847979671006e-29 0.633531527930449 0.911538461538462 27.2 27 2 abnormal myocardium layer morphology 1.9834420810218e-10 4.95860520255449e-09 0.633430016709822 0.911392405063291 27.2 27 2 oxidative stress 1.09946045593179e-11 3.29506973991606e-10 0.633234513618245 0.911111111111111 27.2 27 2 trabecula carnea hypoplasia 1.92427607680509e-06 2.3068128872543e-05 0.633234513618245 0.911111111111111 27.2 27 2 abnormal myocardial trabeculae morphology 1.92427607680509e-06 2.3068128872543e-05 0.633234513618245 0.911111111111111 27.2 27 2 abnormal pulmonary alveolus morphology 6.12919364047661e-13 2.17805274009794e-11 0.633081595358497 0.910891089108911 27.2 27 2 internal hemorrhage 5.59249661549836e-09 1.15927794425435e-07 0.632773476476914 0.91044776119403 27.2 27 2 decreased white adipose tissue amount 5.59249661549836e-09 1.15927794425435e-07 0.632773476476914 0.91044776119403 27.2 27 2 abnormal blood vessel morphology 6.11693740125862e-18 4.41040051757415e-16 0.632701936230845 0.910344827586207 27.2 27 2 small liver 3.07436801149528e-10 7.49753963587697e-09 0.632640484993838 0.91025641025641 27.2 27 2 increased monocyte cell number 9.4944762227439e-13 3.19155535190209e-11 0.632462276406515 0.91 27.2 27 2 abnormal hepatocyte morphology 5.3143361707393e-14 2.24057817368034e-12 0.632399662578537 0.90990990990991 27.2 27 2 abnormal embryo turning 1.59418528773559e-07 2.34647094866408e-06 0.631830445960555 0.909090909090909 27.2 27 2 abnormal aorta morphology 5.73914264344925e-05 0.000478261886954104 0.631830445960555 0.909090909090909 27.2 27 2 enlarged pericardium 5.73914264344925e-05 0.000478261886954104 0.631830445960555 0.909090909090909 27.2 27 2 decreased brown adipose tissue amount 5.73914264344925e-05 0.000478261886954104 0.631830445960555 0.909090909090909 27.2 27 2 single kidney 5.73914264344925e-05 0.000478261886954104 0.631830445960555 0.909090909090909 27.2 27 2 myeloid hyperplasia 5.73914264344925e-05 0.000478261886954104 0.631830445960555 0.909090909090909 27.2 27 2 abnormal astrocyte morphology 2.98437776507787e-06 3.4448444040052e-05 0.631830445960555 0.909090909090909 27.2 27 2 abnormal amino acid level 2.98437776507787e-06 3.4448444040052e-05 0.631830445960555 0.909090909090909 27.2 27 2 embryonic lethality, incomplete penetrance 2.98437776507787e-06 3.4448444040052e-05 0.631830445960555 0.909090909090909 27.2 27 2 abnormal basisphenoid bone morphology 0.0011580258550923 0.00661566410078993 0.631830445960555 0.909090909090909 27.2 27 2 abnormal long bone epiphysis morphology 0.0011580258550923 0.00661566410078993 0.631830445960555 0.909090909090909 27.2 27 2 abnormal facial nerve morphology 0.0011580258550923 0.00661566410078993 0.631830445960555 0.909090909090909 27.2 27 2 abnormal chorion morphology 0.0011580258550923 0.00661566410078993 0.631830445960555 0.909090909090909 27.2 27 2 increased myocardial infarction size 0.0011580258550923 0.00661566410078993 0.631830445960555 0.909090909090909 27.2 27 2 increased coping response 0.0011580258550923 0.00661566410078993 0.631830445960555 0.909090909090909 27.2 27 2 abnormal tracheal cartilage morphology 0.0011580258550923 0.00661566410078993 0.631830445960555 0.909090909090909 27.2 27 2 abnormal blood-brain barrier function 0.0011580258550923 0.00661566410078993 0.631830445960555 0.909090909090909 27.2 27 2 failure of palatal shelf elevation 0.0011580258550923 0.00661566410078993 0.631830445960555 0.909090909090909 27.2 27 2 increased mammary gland tumor incidence 0.0011580258550923 0.00661566410078993 0.631830445960555 0.909090909090909 27.2 27 2 embryonic lethality before implantation, incomplete penetrance 0.0011580258550923 0.00661566410078993 0.631830445960555 0.909090909090909 27.2 27 2 impaired humoral immune response 0.0011580258550923 0.00661566410078993 0.631830445960555 0.909090909090909 27.2 27 2 absent semicircular canals 0.0260357534135285 0.0849155981279988 0.631830445960555 0.909090909090909 27.2 27 2 premature suture closure 0.0260357534135285 0.0849155981279988 0.631830445960555 0.909090909090909 27.2 27 2 abnormal enteric ganglia morphology 0.0260357534135285 0.0849155981279988 0.631830445960555 0.909090909090909 27.2 27 2 abnormal eye distance/ position 0.0260357534135285 0.0849155981279988 0.631830445960555 0.909090909090909 27.2 27 2 abnormal food preference 0.0260357534135285 0.0849155981279988 0.631830445960555 0.909090909090909 27.2 27 2 impaired myelopoiesis 0.0260357534135285 0.0849155981279988 0.631830445960555 0.909090909090909 27.2 27 2 failure of somite differentiation 0.0260357534135285 0.0849155981279988 0.631830445960555 0.909090909090909 27.2 27 2 abnormal hypothalamus secretion 0.0260357534135285 0.0849155981279988 0.631830445960555 0.909090909090909 27.2 27 2 secondary sex reversal 0.0260357534135285 0.0849155981279988 0.631830445960555 0.909090909090909 27.2 27 2 abnormal vestibular ganglion morphology 0.0260357534135285 0.0849155981279988 0.631830445960555 0.909090909090909 27.2 27 2 patent ductus arteriosus 0.0260357534135285 0.0849155981279988 0.631830445960555 0.909090909090909 27.2 27 2 allodynia 0.0260357534135285 0.0849155981279988 0.631830445960555 0.909090909090909 27.2 27 2 abnormal frequency of paradoxical sleep 0.0260357534135285 0.0849155981279988 0.631830445960555 0.909090909090909 27.2 27 2 impaired luteinization 0.0260357534135285 0.0849155981279988 0.631830445960555 0.909090909090909 27.2 27 2 abnormal radial glial cell morphology 0.0260357534135285 0.0849155981279988 0.631830445960555 0.909090909090909 27.2 27 2 pathological neovascularization 0.0260357534135285 0.0849155981279988 0.631830445960555 0.909090909090909 27.2 27 2 abnormal pituitary gland development 0.0260357534135285 0.0849155981279988 0.631830445960555 0.909090909090909 27.2 27 2 abnormal coronal suture morphology 0.0260357534135285 0.0849155981279988 0.631830445960555 0.909090909090909 27.2 27 2 cyclopia 0.0260357534135285 0.0849155981279988 0.631830445960555 0.909090909090909 27.2 27 2 abnormal dorsal-ventral polarity of the somites 0.0260357534135285 0.0849155981279988 0.631830445960555 0.909090909090909 27.2 27 2 increased glycogen level 0.0260357534135285 0.0849155981279988 0.631830445960555 0.909090909090909 27.2 27 2 abnormal platelet aggregation 0.0260357534135285 0.0849155981279988 0.631830445960555 0.909090909090909 27.2 27 2 aberrant origin of the right subclavian artery 0.0260357534135285 0.0849155981279988 0.631830445960555 0.909090909090909 27.2 27 2 common atrioventricular valve 0.0260357534135285 0.0849155981279988 0.631830445960555 0.909090909090909 27.2 27 2 abnormal pulmonary alveolar sac morphology 0.0260357534135285 0.0849155981279988 0.631830445960555 0.909090909090909 27.2 27 2 increased bone mineral content 1.2714310683506e-13 5.06029565203537e-12 0.631250785000958 0.908256880733945 27.2 27 2 polydactyly 2.27167696251731e-12 7.24461082597668e-11 0.631185721015697 0.908163265306122 27.2 27 2 respiratory distress 9.7738224944416e-21 8.84086671088127e-19 0.630734786227675 0.907514450867052 27.2 27 2 axon degeneration 2.46611408274308e-07 3.54592993111179e-06 0.630660389579146 0.907407407407407 27.2 27 2 respiratory failure 3.05501449138464e-18 2.37479642103728e-16 0.630575153683812 0.907284768211921 27.2 27 2 increased sacral vertebrae number 2.06837720397521e-08 3.67506306777738e-07 0.629855975816928 0.90625 27.2 27 2 abnormal vertebral body morphology 8.8905201407614e-05 0.000709957266457271 0.629855975816928 0.90625 27.2 27 2 scoliosis 8.8905201407614e-05 0.000709957266457271 0.629855975816928 0.90625 27.2 27 2 kidney cortex cysts 8.8905201407614e-05 0.000709957266457271 0.629855975816928 0.90625 27.2 27 2 abnormal lymphatic vessel morphology 8.8905201407614e-05 0.000709957266457271 0.629855975816928 0.90625 27.2 27 2 abnormal long term potentiation 8.8905201407614e-05 0.000709957266457271 0.629855975816928 0.90625 27.2 27 2 abnormal serotonin level 8.8905201407614e-05 0.000709957266457271 0.629855975816928 0.90625 27.2 27 2 abnormal mesoderm development 3.80828390668293e-07 5.30706230693209e-06 0.629446180126741 0.905660377358491 27.2 27 2 decreased body length 1.6379067115658e-31 3.39524412084993e-29 0.629063305321312 0.905109489051095 27.2 27 2 decreased susceptibility to hepatic steatosis 3.18919587947204e-08 5.43364708916897e-07 0.628821729551219 0.904761904761905 27.2 27 2 decreased exploration in new environment 1.49645146599568e-10 3.89782515357514e-09 0.628821729551219 0.904761904761905 27.2 27 2 abnormal pancreas morphology 7.13349878775952e-06 7.53485275352518e-05 0.628821729551219 0.904761904761905 27.2 27 2 abnormal reproductive system morphology 7.13349878775952e-06 7.53485275352518e-05 0.628821729551219 0.904761904761905 27.2 27 2 small ears 0.00179708631326133 0.00961344560051086 0.628821729551219 0.904761904761905 27.2 27 2 abnormal eye pigmentation 0.00179708631326133 0.00961344560051086 0.628821729551219 0.904761904761905 27.2 27 2 abnormal hematopoietic system physiology 0.00179708631326133 0.00961344560051086 0.628821729551219 0.904761904761905 27.2 27 2 liver degeneration 0.00179708631326133 0.00961344560051086 0.628821729551219 0.904761904761905 27.2 27 2 abnormal clavicle morphology 0.00179708631326133 0.00961344560051086 0.628821729551219 0.904761904761905 27.2 27 2 prenatal lethality, incomplete penetrance 1.08166419670814e-34 2.56251398982049e-32 0.62871286152325 0.904605263157895 27.2 27 2 abnormal vitelline vasculature morphology 6.22861071758191e-14 2.56093705123719e-12 0.628533939285978 0.904347826086957 27.2 27 2 seminiferous tubule degeneration 2.6996171483326e-09 5.83938926650204e-08 0.628368361325155 0.904109589041096 27.2 27 2 abnormal placenta vasculature 5.87028095381068e-07 7.95766968534282e-06 0.628185270310783 0.903846153846154 27.2 27 2 decreased birth body size 9.58055614718986e-14 3.87506234408696e-12 0.627950785327464 0.903508771929825 27.2 27 2 abnormal nose morphology 0.000137335791852616 0.00106094031749497 0.627754120502745 0.903225806451613 27.2 27 2 decreased thymus weight 0.000137335791852616 0.00106094031749497 0.627754120502745 0.903225806451613 27.2 27 2 inner cell mass degeneration 0.000137335791852616 0.00106094031749497 0.627754120502745 0.903225806451613 27.2 27 2 small cranium 0.000137335791852616 0.00106094031749497 0.627754120502745 0.903225806451613 27.2 27 2 abnormal forebrain development 4.15223038036449e-09 8.71617980688327e-08 0.627442734530273 0.902777777777778 27.2 27 2 premature death 5.30443626552988e-95 6.59739260525278e-92 0.627207296355965 0.902439024390244 27.2 27 2 short humerus 1.09920864522467e-05 0.00010981050220869 0.627207296355965 0.902439024390244 27.2 27 2 lethality at weaning, incomplete penetrance 1.09920864522467e-05 0.00010981050220869 0.627207296355965 0.902439024390244 27.2 27 2 hemorrhage 1.19884881759803e-26 1.70407796215721e-24 0.626990893608517 0.902127659574468 27.2 27 2 abnormal trophoblast layer morphology 9.03174921367513e-07 1.17625529680717e-05 0.62687491305106 0.901960784313726 27.2 27 2 increased circulating free fatty acid level 6.37744696592451e-09 1.29501219001936e-07 0.62649103374117 0.901408450704225 27.2 27 2 embryonic lethality during organogenesis, incomplete penetrance 1.02027152186544e-25 1.33575021612646e-23 0.625512141500949 0.9 27.2 27 2 abnormal kidney development 1.15790822887668e-07 1.7670532020434e-06 0.625512141500949 0.9 27.2 27 2 abnormal eating behavior 1.15790822887668e-07 1.7670532020434e-06 0.625512141500949 0.9 27.2 27 2 abnormal incisor morphology 1.15790822887668e-07 1.7670532020434e-06 0.625512141500949 0.9 27.2 27 2 muscular ventricular septal defect 1.15790822887668e-07 1.7670532020434e-06 0.625512141500949 0.9 27.2 27 2 abnormal hindlimb morphology 1.38687240352898e-06 1.72924566605431e-05 0.625512141500949 0.9 27.2 27 2 decreased circulating alkaline phosphatase level 1.38687240352898e-06 1.72924566605431e-05 0.625512141500949 0.9 27.2 27 2 decreased respiratory quotient 1.38687240352898e-06 1.72924566605431e-05 0.625512141500949 0.9 27.2 27 2 delayed eyelid opening 0.000211514369306458 0.00153618100335712 0.625512141500949 0.9 27.2 27 2 abnormal lactation 0.000211514369306458 0.00153618100335712 0.625512141500949 0.9 27.2 27 2 emphysema 0.000211514369306458 0.00153618100335712 0.625512141500949 0.9 27.2 27 2 abnormal optic cup morphology 0.000211514369306458 0.00153618100335712 0.625512141500949 0.9 27.2 27 2 abnormal social investigation 8.33131669574774e-10 1.91890280376597e-08 0.625512141500949 0.9 27.2 27 2 perinatal lethality 1.68978504217904e-05 0.000160050263813344 0.625512141500949 0.9 27.2 27 2 abnormal vascular regression 0.00277741396820371 0.0140423114754202 0.625512141500949 0.9 27.2 27 2 abnormal circulating enzyme level 0.00277741396820371 0.0140423114754202 0.625512141500949 0.9 27.2 27 2 increased mammary adenocarcinoma incidence 0.00277741396820371 0.0140423114754202 0.625512141500949 0.9 27.2 27 2 abnormal hearing physiology 0.00277741396820371 0.0140423114754202 0.625512141500949 0.9 27.2 27 2 abnormal lens epithelium morphology 0.00277741396820371 0.0140423114754202 0.625512141500949 0.9 27.2 27 2 dilated vasculature 0.00277741396820371 0.0140423114754202 0.625512141500949 0.9 27.2 27 2 kidney atrophy 0.00277741396820371 0.0140423114754202 0.625512141500949 0.9 27.2 27 2 decreased circulating VLDL cholesterol level 0.00277741396820371 0.0140423114754202 0.625512141500949 0.9 27.2 27 2 abnormal sperm mitochondrial sheath morphology 0.00277741396820371 0.0140423114754202 0.625512141500949 0.9 27.2 27 2 abnormal heart electrocardiography waveform feature 0.00277741396820371 0.0140423114754202 0.625512141500949 0.9 27.2 27 2 decreased muscle cell glucose uptake 0.00277741396820371 0.0140423114754202 0.625512141500949 0.9 27.2 27 2 retarded hair growth 0.0405894522641871 0.120797179207342 0.625512141500949 0.9 27.2 27 2 absent maxillary shelf 0.0405894522641871 0.120797179207342 0.625512141500949 0.9 27.2 27 2 absent palatine bone horizontal plate 0.0405894522641871 0.120797179207342 0.625512141500949 0.9 27.2 27 2 increased cranium width 0.0405894522641871 0.120797179207342 0.625512141500949 0.9 27.2 27 2 jaundice 0.0405894522641871 0.120797179207342 0.625512141500949 0.9 27.2 27 2 small petrosal ganglion 0.0405894522641871 0.120797179207342 0.625512141500949 0.9 27.2 27 2 abnormal epidermis suprabasal layer morphology 0.0405894522641871 0.120797179207342 0.625512141500949 0.9 27.2 27 2 fused cornea and lens 0.0405894522641871 0.120797179207342 0.625512141500949 0.9 27.2 27 2 abnormal grooming behavior 0.0405894522641871 0.120797179207342 0.625512141500949 0.9 27.2 27 2 rhinitis 0.0405894522641871 0.120797179207342 0.625512141500949 0.9 27.2 27 2 abnormal respiratory mechanics 0.0405894522641871 0.120797179207342 0.625512141500949 0.9 27.2 27 2 abnormal neuron specification 0.0405894522641871 0.120797179207342 0.625512141500949 0.9 27.2 27 2 abnormal tibialis anterior morphology 0.0405894522641871 0.120797179207342 0.625512141500949 0.9 27.2 27 2 acrania 0.0405894522641871 0.120797179207342 0.625512141500949 0.9 27.2 27 2 intestinal edema 0.0405894522641871 0.120797179207342 0.625512141500949 0.9 27.2 27 2 intestinal hypoperistalsis 0.0405894522641871 0.120797179207342 0.625512141500949 0.9 27.2 27 2 cochlear ganglion hypoplasia 0.0405894522641871 0.120797179207342 0.625512141500949 0.9 27.2 27 2 absent seminal vesicle 0.0405894522641871 0.120797179207342 0.625512141500949 0.9 27.2 27 2 absent CD4-positive, alpha beta T cells 0.0405894522641871 0.120797179207342 0.625512141500949 0.9 27.2 27 2 abnormal pillar cell morphology 0.0405894522641871 0.120797179207342 0.625512141500949 0.9 27.2 27 2 abnormal hindlimb zeugopod morphology 0.0405894522641871 0.120797179207342 0.625512141500949 0.9 27.2 27 2 increased defecation amount 0.0405894522641871 0.120797179207342 0.625512141500949 0.9 27.2 27 2 absent pharyngeal arches 0.0405894522641871 0.120797179207342 0.625512141500949 0.9 27.2 27 2 abnormal ear physiology 0.0405894522641871 0.120797179207342 0.625512141500949 0.9 27.2 27 2 abnormal reproductive system development 0.0405894522641871 0.120797179207342 0.625512141500949 0.9 27.2 27 2 abnormal gas homeostasis 0.0405894522641871 0.120797179207342 0.625512141500949 0.9 27.2 27 2 abnormal plasma membrane morphology 0.0405894522641871 0.120797179207342 0.625512141500949 0.9 27.2 27 2 abnormal embryonic erythrocyte morphology 0.0405894522641871 0.120797179207342 0.625512141500949 0.9 27.2 27 2 abnormal utricular macula morphology 0.0405894522641871 0.120797179207342 0.625512141500949 0.9 27.2 27 2 decreased cochlear inner hair cell number 0.0405894522641871 0.120797179207342 0.625512141500949 0.9 27.2 27 2 abnormal cochlear inner hair cell physiology 0.0405894522641871 0.120797179207342 0.625512141500949 0.9 27.2 27 2 absent coat pigmentation 0.0405894522641871 0.120797179207342 0.625512141500949 0.9 27.2 27 2 abnormal corneal endothelium morphology 0.0405894522641871 0.120797179207342 0.625512141500949 0.9 27.2 27 2 abnormal gonadal fat pad morphology 0.0405894522641871 0.120797179207342 0.625512141500949 0.9 27.2 27 2 tachypnea 0.0405894522641871 0.120797179207342 0.625512141500949 0.9 27.2 27 2 impaired behavioral response to morphine 0.0405894522641871 0.120797179207342 0.625512141500949 0.9 27.2 27 2 abnormal retinal blood vessel pattern 0.0405894522641871 0.120797179207342 0.625512141500949 0.9 27.2 27 2 umbilical hernia 0.0405894522641871 0.120797179207342 0.625512141500949 0.9 27.2 27 2 abnormal vibrissa follicle morphology 0.0405894522641871 0.120797179207342 0.625512141500949 0.9 27.2 27 2 increased kidney iron level 0.0405894522641871 0.120797179207342 0.625512141500949 0.9 27.2 27 2 abnormal heart and great artery attachment 0.0405894522641871 0.120797179207342 0.625512141500949 0.9 27.2 27 2 abnormal left subclavian artery morphology 0.0405894522641871 0.120797179207342 0.625512141500949 0.9 27.2 27 2 thick aortic valve 0.0405894522641871 0.120797179207342 0.625512141500949 0.9 27.2 27 2 decreased trabecular bone connectivity density 0.0405894522641871 0.120797179207342 0.625512141500949 0.9 27.2 27 2 increased compact bone area 0.0405894522641871 0.120797179207342 0.625512141500949 0.9 27.2 27 2 abnormal adaptive thermogenesis 0.0405894522641871 0.120797179207342 0.625512141500949 0.9 27.2 27 2 decreased macrophage cytokine production 0.0405894522641871 0.120797179207342 0.625512141500949 0.9 27.2 27 2 lethality during fetal growth through weaning, complete penetrance 0.0405894522641871 0.120797179207342 0.625512141500949 0.9 27.2 27 2 increased fatty acid oxidation 0.0405894522641871 0.120797179207342 0.625512141500949 0.9 27.2 27 2 abnormal somite development 1.27563356444477e-09 2.85868332572645e-08 0.624632377588852 0.89873417721519 27.2 27 2 abnormal placenta morphology 1.27563356444477e-09 2.85868332572645e-08 0.624632377588852 0.89873417721519 27.2 27 2 perimembraneous ventricular septal defect 1.49784277906724e-08 2.79092427934813e-07 0.624504875572606 0.898550724637681 27.2 27 2 abnormal thoracic vertebrae morphology 1.7736786302037e-07 2.58769829479866e-06 0.624334152533904 0.898305084745763 27.2 27 2 perinatal lethality, incomplete penetrance 5.60838070588345e-25 6.97542350294254e-23 0.624282029128283 0.898230088495575 27.2 27 2 abnormal respiratory system physiology 2.12529461983662e-06 2.52950735255674e-05 0.624093746622262 0.897959183673469 27.2 27 2 abnormal suckling behavior 1.67161416118894e-10 4.30895360202848e-09 0.623932565386048 0.897727272727273 27.2 27 2 postnatal lethality 1.26168275504129e-18 1.0461452843884e-16 0.623837410198403 0.897590361445783 27.2 27 2 absent gastric milk in neonates 1.95051680769239e-09 4.29372615852639e-08 0.623730055627727 0.897435897435897 27.2 27 2 increased hepatocyte apoptosis 2.59123063860339e-05 0.000234685845119539 0.623730055627727 0.897435897435897 27.2 27 2 double outlet right ventricle 1.90042331730396e-12 6.13494504328137e-11 0.623563505546118 0.897196261682243 27.2 27 2 infertility 1.90042331730396e-12 6.13494504328137e-11 0.623563505546118 0.897196261682243 27.2 27 2 pericardial edema 2.29025229751621e-08 4.04042736884509e-07 0.623467984175783 0.897058823529412 27.2 27 2 decreased mean corpuscular hemoglobin 2.29025229751621e-08 4.04042736884509e-07 0.623467984175783 0.897058823529412 27.2 27 2 abnormal myocardial fiber morphology 2.19867080050764e-11 6.47241848078431e-10 0.623362615241496 0.896907216494845 27.2 27 2 enlarged heart 2.6728899366688e-25 3.40964806023776e-23 0.623115543257651 0.896551724137931 27.2 27 2 cochlear ganglion degeneration 2.71208229714532e-07 3.85503126522799e-06 0.623115543257651 0.896551724137931 27.2 27 2 abnormal parietal bone morphology 0.000324721685386031 0.00222213257881087 0.623115543257651 0.896551724137931 27.2 27 2 aphagia 0.000324721685386031 0.00222213257881087 0.623115543257651 0.896551724137931 27.2 27 2 short sternum 0.000324721685386031 0.00222213257881087 0.623115543257651 0.896551724137931 27.2 27 2 abnormal rib morphology 2.90185650540894e-15 1.53582299089463e-13 0.622938017461851 0.896296296296296 27.2 27 2 cyanosis 4.57186383959634e-21 4.21204122259107e-19 0.622616251956963 0.895833333333333 27.2 27 2 oligodactyly 3.25000536205216e-06 3.69994889615778e-05 0.622616251956963 0.895833333333333 27.2 27 2 abnormal nervous system physiology 3.83514210846561e-13 1.41332088811973e-11 0.622490343715921 0.895652173913044 27.2 27 2 abnormal skeleton morphology 3.83514210846561e-13 1.41332088811973e-11 0.622490343715921 0.895652173913044 27.2 27 2 increased circulating creatinine level 3.89398500755681e-10 9.40416282164813e-09 0.62227952061464 0.895348837209302 27.2 27 2 increased tumor incidence 5.08063100753344e-14 2.17897752262749e-12 0.622149172998256 0.895161290322581 27.2 27 2 decreased birth weight 5.11248067667027e-11 1.42890962732779e-09 0.621854175761178 0.894736842105263 27.2 27 2 abnormal frontal bone morphology 3.96323333517091e-05 0.000342310518098529 0.621854175761178 0.894736842105263 27.2 27 2 hyporesponsive to tactile stimuli 3.96323333517091e-05 0.000342310518098529 0.621854175761178 0.894736842105263 27.2 27 2 shiny skin 0.00427330464839824 0.0200563119111144 0.621854175761178 0.894736842105263 27.2 27 2 thin dermal layer 0.00427330464839824 0.0200563119111144 0.621854175761178 0.894736842105263 27.2 27 2 stereotypic behavior 0.00427330464839824 0.0200563119111144 0.621854175761178 0.894736842105263 27.2 27 2 abnormal ear morphology 0.00427330464839824 0.0200563119111144 0.621854175761178 0.894736842105263 27.2 27 2 abnormal metatarsal bone morphology 0.00427330464839824 0.0200563119111144 0.621854175761178 0.894736842105263 27.2 27 2 increased susceptibility to ischemic brain injury 0.00427330464839824 0.0200563119111144 0.621854175761178 0.894736842105263 27.2 27 2 abnormal digestive system development 0.00427330464839824 0.0200563119111144 0.621854175761178 0.894736842105263 27.2 27 2 maternal imprinting 0.00427330464839824 0.0200563119111144 0.621854175761178 0.894736842105263 27.2 27 2 increased left ventricle weight 0.00427330464839824 0.0200563119111144 0.621854175761178 0.894736842105263 27.2 27 2 decreased liver regeneration 0.00427330464839824 0.0200563119111144 0.621854175761178 0.894736842105263 27.2 27 2 increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 0.00427330464839824 0.0200563119111144 0.621854175761178 0.894736842105263 27.2 27 2 shortened RR interval 0.00427330464839824 0.0200563119111144 0.621854175761178 0.894736842105263 27.2 27 2 abnormal cardiovascular system physiology 6.74075173862317e-15 3.19383237139527e-13 0.621854175761178 0.894736842105263 27.2 27 2 impaired swimming 5.32885592958305e-08 8.6637445260378e-07 0.621299938527879 0.893939393939394 27.2 27 2 abnormal skin morphology 5.32885592958305e-08 8.6637445260378e-07 0.621299938527879 0.893939393939394 27.2 27 2 decreased hemoglobin content 1.36243052282547e-15 7.70237710347354e-14 0.621075885178248 0.893617021276596 27.2 27 2 abnormal innervation 4.95899184671571e-06 5.43302865527838e-05 0.621075885178248 0.893617021276596 27.2 27 2 decreased body size 2.45585533072253e-82 2.44357605406892e-79 0.620983231537423 0.893483709273183 27.2 27 2 rib bifurcation 0.000496827052719864 0.00322257442931072 0.620547759425545 0.892857142857143 27.2 27 2 abnormal retinal inner nuclear layer morphology 0.000496827052719864 0.00322257442931072 0.620547759425545 0.892857142857143 27.2 27 2 increased bone resorption 0.000496827052719864 0.00322257442931072 0.620547759425545 0.892857142857143 27.2 27 2 abnormal mitotic spindle morphology 0.000496827052719864 0.00322257442931072 0.620547759425545 0.892857142857143 27.2 27 2 increased or absent threshold for auditory brainstem response 2.49184697474217e-30 4.13231289978077e-28 0.620461870462303 0.892733564013841 27.2 27 2 postnatal lethality, incomplete penetrance 2.17786284689424e-58 1.20387418481098e-55 0.620372957239791 0.892605633802817 27.2 27 2 increased heart weight 3.14636339513658e-15 1.63053728029213e-13 0.620012034741149 0.892086330935252 27.2 27 2 abnormal intestine morphology 1.05110822442816e-08 2.04268102208207e-07 0.619876896982923 0.891891891891892 27.2 27 2 pale liver 1.05110822442816e-08 2.04268102208207e-07 0.619876896982923 0.891891891891892 27.2 27 2 abnormal calcium ion homeostasis 6.04510220899599e-05 0.00050123972482925 0.619876896982923 0.891891891891892 27.2 27 2 decreased erythrocyte cell number 5.55850832727277e-17 3.37238767416854e-15 0.61975725272564 0.89171974522293 27.2 27 2 decreased circulating total protein level 9.5868659086376e-07 1.24204838269459e-05 0.619193837041344 0.890909090909091 27.2 27 2 decreased lymphocyte cell number 5.45857335005241e-14 2.2820506232362e-12 0.618996390026981 0.890625 27.2 27 2 neonatal lethality, complete penetrance 2.70745431278162e-46 1.12246543384071e-43 0.618805870978035 0.890350877192982 27.2 27 2 decreased body weight 6.32351957400884e-125 1.5729754940347e-121 0.618663058637629 0.890145395799677 27.2 27 2 increased thermal nociceptive threshold 2.72445233717678e-10 6.77707518872723e-09 0.618638381704236 0.89010989010989 27.2 27 2 abnormal vertebrae morphology 4.72416388344088e-12 1.47815819623386e-10 0.618498243889828 0.889908256880734 27.2 27 2 abnormal embryo development 1.09710074152666e-14 5.14912848027845e-13 0.618357590862867 0.889705882352941 27.2 27 2 increased blood urea nitrogen level 1.45703082894485e-15 8.14463862247261e-14 0.618322346771053 0.889655172413793 27.2 27 2 decreased bone mineral content 1.08044267737165e-21 1.05396123920077e-19 0.618161037273908 0.889423076923077 27.2 27 2 increased exploration in new environment 3.15090742221553e-09 6.72779589078209e-08 0.617789769383654 0.888888888888889 27.2 27 2 decreased heart weight 3.15090742221553e-09 6.72779589078209e-08 0.617789769383654 0.888888888888889 27.2 27 2 abnormal cell adhesion 1.45456424982017e-06 1.80911428571384e-05 0.617789769383654 0.888888888888889 27.2 27 2 renal hypoplasia 9.19400864019118e-05 0.000729508660047067 0.617789769383654 0.888888888888889 27.2 27 2 short radius 9.19400864019118e-05 0.000729508660047067 0.617789769383654 0.888888888888889 27.2 27 2 abnormal retinal blood vessel morphology 9.19400864019118e-05 0.000729508660047067 0.617789769383654 0.888888888888889 27.2 27 2 decreased susceptibility to pharmacologically induced seizures 0.000757389634508421 0.00461201154428323 0.617789769383654 0.888888888888889 27.2 27 2 decreased circulating fructosamine level 0.000757389634508421 0.00461201154428323 0.617789769383654 0.888888888888889 27.2 27 2 decreased bone ossification 0.000757389634508421 0.00461201154428323 0.617789769383654 0.888888888888889 27.2 27 2 lowered ear position 0.00654250248845572 0.0284177659278042 0.617789769383654 0.888888888888889 27.2 27 2 abnormal stomach glandular epithelium morphology 0.00654250248845572 0.0284177659278042 0.617789769383654 0.888888888888889 27.2 27 2 blepharoptosis 0.00654250248845572 0.0284177659278042 0.617789769383654 0.888888888888889 27.2 27 2 abnormal thymus cortex morphology 0.00654250248845572 0.0284177659278042 0.617789769383654 0.888888888888889 27.2 27 2 abnormal thymus medulla morphology 0.00654250248845572 0.0284177659278042 0.617789769383654 0.888888888888889 27.2 27 2 acidosis 0.00654250248845572 0.0284177659278042 0.617789769383654 0.888888888888889 27.2 27 2 abnormal metacarpal bone morphology 0.00654250248845572 0.0284177659278042 0.617789769383654 0.888888888888889 27.2 27 2 increased circulating renin level 0.00654250248845572 0.0284177659278042 0.617789769383654 0.888888888888889 27.2 27 2 increased circulating glycerol level 0.00654250248845572 0.0284177659278042 0.617789769383654 0.888888888888889 27.2 27 2 absent inner cell mass 0.00654250248845572 0.0284177659278042 0.617789769383654 0.888888888888889 27.2 27 2 decreased lactate dehydrogenase level 0.00654250248845572 0.0284177659278042 0.617789769383654 0.888888888888889 27.2 27 2 abnormal pregnancy 0.00654250248845572 0.0284177659278042 0.617789769383654 0.888888888888889 27.2 27 2 primary atelectasis 0.00654250248845572 0.0284177659278042 0.617789769383654 0.888888888888889 27.2 27 2 increased effector memory CD8-positive, alpha-beta T cell number 0.00654250248845572 0.0284177659278042 0.617789769383654 0.888888888888889 27.2 27 2 increased adipocyte glucose uptake 0.00654250248845572 0.0284177659278042 0.617789769383654 0.888888888888889 27.2 27 2 distorted hair follicle pattern 0.0627936274385904 0.16895527123147 0.617789769383654 0.888888888888889 27.2 27 2 renal tubular acidosis 0.0627936274385904 0.16895527123147 0.617789769383654 0.888888888888889 27.2 27 2 synostosis 0.0627936274385904 0.16895527123147 0.617789769383654 0.888888888888889 27.2 27 2 thick tail 0.0627936274385904 0.16895527123147 0.617789769383654 0.888888888888889 27.2 27 2 absent parathyroid glands 0.0627936274385904 0.16895527123147 0.617789769383654 0.888888888888889 27.2 27 2 abnormal cholinergic neuron morphology 0.0627936274385904 0.16895527123147 0.617789769383654 0.888888888888889 27.2 27 2 absent enteric neurons 0.0627936274385904 0.16895527123147 0.617789769383654 0.888888888888889 27.2 27 2 abnormal geniculate ganglion morphology 0.0627936274385904 0.16895527123147 0.617789769383654 0.888888888888889 27.2 27 2 small nodose ganglion 0.0627936274385904 0.16895527123147 0.617789769383654 0.888888888888889 27.2 27 2 dilated uterus 0.0627936274385904 0.16895527123147 0.617789769383654 0.888888888888889 27.2 27 2 abnormal vagina epithelium morphology 0.0627936274385904 0.16895527123147 0.617789769383654 0.888888888888889 27.2 27 2 decreased level of surface class I molecules 0.0627936274385904 0.16895527123147 0.617789769383654 0.888888888888889 27.2 27 2 abnormal lung volume 0.0627936274385904 0.16895527123147 0.617789769383654 0.888888888888889 27.2 27 2 abnormal vomeronasal organ morphology 0.0627936274385904 0.16895527123147 0.617789769383654 0.888888888888889 27.2 27 2 abnormal thymus lobule morphology 0.0627936274385904 0.16895527123147 0.617789769383654 0.888888888888889 27.2 27 2 abnormal gut-associated lymphoid tissue morphology 0.0627936274385904 0.16895527123147 0.617789769383654 0.888888888888889 27.2 27 2 decreased circulating bicarbonate level 0.0627936274385904 0.16895527123147 0.617789769383654 0.888888888888889 27.2 27 2 genetic imprinting 0.0627936274385904 0.16895527123147 0.617789769383654 0.888888888888889 27.2 27 2 biliary cyst 0.0627936274385904 0.16895527123147 0.617789769383654 0.888888888888889 27.2 27 2 pancreas cysts 0.0627936274385904 0.16895527123147 0.617789769383654 0.888888888888889 27.2 27 2 abnormal artery development 0.0627936274385904 0.16895527123147 0.617789769383654 0.888888888888889 27.2 27 2 decreased fear-related response 0.0627936274385904 0.16895527123147 0.617789769383654 0.888888888888889 27.2 27 2 abnormal thymus physiology 0.0627936274385904 0.16895527123147 0.617789769383654 0.888888888888889 27.2 27 2 decreased muscle weight 0.0627936274385904 0.16895527123147 0.617789769383654 0.888888888888889 27.2 27 2 decreased vestibular hair cell number 0.0627936274385904 0.16895527123147 0.617789769383654 0.888888888888889 27.2 27 2 small scapula 0.0627936274385904 0.16895527123147 0.617789769383654 0.888888888888889 27.2 27 2 abnormal stria vascularis vasculature morphology 0.0627936274385904 0.16895527123147 0.617789769383654 0.888888888888889 27.2 27 2 abnormal CNS synapse formation 0.0627936274385904 0.16895527123147 0.617789769383654 0.888888888888889 27.2 27 2 liver hyperplasia 0.0627936274385904 0.16895527123147 0.617789769383654 0.888888888888889 27.2 27 2 hemothorax 0.0627936274385904 0.16895527123147 0.617789769383654 0.888888888888889 27.2 27 2 abnormal inguinal fat pad morphology 0.0627936274385904 0.16895527123147 0.617789769383654 0.888888888888889 27.2 27 2 decreased susceptibility to atherosclerosis 0.0627936274385904 0.16895527123147 0.617789769383654 0.888888888888889 27.2 27 2 increased tidal volume 0.0627936274385904 0.16895527123147 0.617789769383654 0.888888888888889 27.2 27 2 enhanced conditioned place preference behavior 0.0627936274385904 0.16895527123147 0.617789769383654 0.888888888888889 27.2 27 2 abnormal optic chiasm morphology 0.0627936274385904 0.16895527123147 0.617789769383654 0.888888888888889 27.2 27 2 eye opacity 0.0627936274385904 0.16895527123147 0.617789769383654 0.888888888888889 27.2 27 2 abnormal telomere morphology 0.0627936274385904 0.16895527123147 0.617789769383654 0.888888888888889 27.2 27 2 retropulsion 0.0627936274385904 0.16895527123147 0.617789769383654 0.888888888888889 27.2 27 2 abnormal ventricle myocardium morphology 0.0627936274385904 0.16895527123147 0.617789769383654 0.888888888888889 27.2 27 2 prolonged RR interval 0.0627936274385904 0.16895527123147 0.617789769383654 0.888888888888889 27.2 27 2 shortened ST segment 0.0627936274385904 0.16895527123147 0.617789769383654 0.888888888888889 27.2 27 2 iris coloboma 0.0627936274385904 0.16895527123147 0.617789769383654 0.888888888888889 27.2 27 2 fusion of atlas and occipital bones 0.0627936274385904 0.16895527123147 0.617789769383654 0.888888888888889 27.2 27 2 abnormal oxidative phosphorylation 0.0627936274385904 0.16895527123147 0.617789769383654 0.888888888888889 27.2 27 2 abnormal ureteric bud invasion 0.0627936274385904 0.16895527123147 0.617789769383654 0.888888888888889 27.2 27 2 increased core body temperature 0.0627936274385904 0.16895527123147 0.617789769383654 0.888888888888889 27.2 27 2 decreased pancreatic beta cell proliferation 0.0627936274385904 0.16895527123147 0.617789769383654 0.888888888888889 27.2 27 2 trigeminal neuroma 0.0627936274385904 0.16895527123147 0.617789769383654 0.888888888888889 27.2 27 2 abnormal coronary sinus connection 0.0627936274385904 0.16895527123147 0.617789769383654 0.888888888888889 27.2 27 2 decreased bone mineral density of femur 0.0627936274385904 0.16895527123147 0.617789769383654 0.888888888888889 27.2 27 2 increased endoplasmic reticulum stress 0.0627936274385904 0.16895527123147 0.617789769383654 0.888888888888889 27.2 27 2 decreased startle reflex 9.45405415797974e-13 3.19155535190209e-11 0.617789769383654 0.888888888888889 27.2 27 2 abnormal cartilage development 1.14651912712601e-05 0.000113398263567633 0.617789769383654 0.888888888888889 27.2 27 2 small placenta 1.14651912712601e-05 0.000113398263567633 0.617789769383654 0.888888888888889 27.2 27 2 cardiomyopathy 1.14651912712601e-05 0.000113398263567633 0.617789769383654 0.888888888888889 27.2 27 2 postnatal lethality, complete penetrance 7.28349679088103e-39 2.26471228341457e-36 0.617589707929838 0.88860103626943 27.2 27 2 abnormal ovary morphology 3.65835547584014e-08 6.08706304090458e-07 0.616702111338964 0.887323943661972 27.2 27 2 abnormal skeletal muscle fiber morphology 3.65835547584014e-08 6.08706304090458e-07 0.616702111338964 0.887323943661972 27.2 27 2 decreased blood urea nitrogen level 1.73688564428978e-05 0.000163965959778779 0.616034684811541 0.886363636363636 27.2 27 2 decreased total body fat amount 3.25187816051231e-33 7.0339538471951e-31 0.615940099415439 0.88622754491018 27.2 27 2 hypoactivity 3.04129248458104e-37 8.90025300634744e-35 0.615741394816732 0.885941644562334 27.2 27 2 increased carcinoma incidence 0.000139407162812569 0.00106209898161184 0.615583377350141 0.885714285714286 27.2 27 2 abnormal artery morphology 0.000139407162812569 0.00106209898161184 0.615583377350141 0.885714285714286 27.2 27 2 increased circulating serum albumin level 0.000139407162812569 0.00106209898161184 0.615583377350141 0.885714285714286 27.2 27 2 decreased triglyceride level 0.000139407162812569 0.00106209898161184 0.615583377350141 0.885714285714286 27.2 27 2 decreased circulating thyroxine level 0.000139407162812569 0.00106209898161184 0.615583377350141 0.885714285714286 27.2 27 2 impaired behavioral response to xenobiotic 0.000139407162812569 0.00106209898161184 0.615583377350141 0.885714285714286 27.2 27 2 abnormal hippocampus pyramidal cell morphology 0.000139407162812569 0.00106209898161184 0.615583377350141 0.885714285714286 27.2 27 2 decreased bone volume 0.000139407162812569 0.00106209898161184 0.615583377350141 0.885714285714286 27.2 27 2 impaired adaptive thermogenesis 0.000139407162812569 0.00106209898161184 0.615583377350141 0.885714285714286 27.2 27 2 postnatal growth retardation 1.27576111013438e-59 7.93363940364819e-57 0.615518483466802 0.88562091503268 27.2 27 2 increased rib number 1.08580507346978e-08 2.07846208018331e-07 0.614819626261617 0.884615384615385 27.2 27 2 abnormal skin condition 3.32696725393026e-06 3.77031027068406e-05 0.614819626261617 0.884615384615385 27.2 27 2 abnormal female meiosis 3.32696725393026e-06 3.77031027068406e-05 0.614819626261617 0.884615384615385 27.2 27 2 abnormal xiphoid process morphology 0.00115011257471537 0.00661566410078993 0.614819626261617 0.884615384615385 27.2 27 2 increased leukemia incidence 0.00115011257471537 0.00661566410078993 0.614819626261617 0.884615384615385 27.2 27 2 abnormal neuron differentiation 7.39856311205099e-12 2.24438118795449e-10 0.614342281831289 0.883928571428571 27.2 27 2 abnormal organ of Corti morphology 2.62438597020228e-05 0.000234825902909287 0.614197968398865 0.883720930232558 27.2 27 2 abnormal vasculogenesis 2.62438597020228e-05 0.000234825902909287 0.614197968398865 0.883720930232558 27.2 27 2 abnormal left-right axis patterning 2.62438597020228e-05 0.000234825902909287 0.614197968398865 0.883720930232558 27.2 27 2 kidney failure 2.62438597020228e-05 0.000234825902909287 0.614197968398865 0.883720930232558 27.2 27 2 abnormal double-strand DNA break repair 2.62438597020228e-05 0.000234825902909287 0.614197968398865 0.883720930232558 27.2 27 2 increased circulating alkaline phosphatase level 2.09457811993848e-16 1.22594425255223e-14 0.613499562651823 0.882716049382716 27.2 27 2 microphthalmia 1.57025234448012e-15 8.68000601532068e-14 0.61324719754995 0.882352941176471 27.2 27 2 decreased circulating alanine transaminase level 1.25419362709874e-07 1.90813862226796e-06 0.61324719754995 0.882352941176471 27.2 27 2 impaired hematopoiesis 5.01460351973992e-06 5.43521841191854e-05 0.61324719754995 0.882352941176471 27.2 27 2 abnormal gastrulation 5.01460351973992e-06 5.43521841191854e-05 0.61324719754995 0.882352941176471 27.2 27 2 abnormal cervical vertebrae morphology 5.01460351973992e-06 5.43521841191854e-05 0.61324719754995 0.882352941176471 27.2 27 2 increased kidney weight 5.01460351973992e-06 5.43521841191854e-05 0.61324719754995 0.882352941176471 27.2 27 2 short maxilla 0.000210702719725103 0.00153618100335712 0.61324719754995 0.882352941176471 27.2 27 2 lung hemorrhage 0.000210702719725103 0.00153618100335712 0.61324719754995 0.882352941176471 27.2 27 2 abnormal bone remodeling 0.000210702719725103 0.00153618100335712 0.61324719754995 0.882352941176471 27.2 27 2 abnormal adipose tissue morphology 0.00996220333860888 0.0402288649428402 0.61324719754995 0.882352941176471 27.2 27 2 distended urinary bladder 0.00996220333860888 0.0402288649428402 0.61324719754995 0.882352941176471 27.2 27 2 increased aggression towards mice 0.00996220333860888 0.0402288649428402 0.61324719754995 0.882352941176471 27.2 27 2 abnormal heart rate 0.00996220333860888 0.0402288649428402 0.61324719754995 0.882352941176471 27.2 27 2 abnormal touch/ nociception 0.00996220333860888 0.0402288649428402 0.61324719754995 0.882352941176471 27.2 27 2 abnormal cranial suture morphology 0.00996220333860888 0.0402288649428402 0.61324719754995 0.882352941176471 27.2 27 2 abnormal duodenum morphology 0.00996220333860888 0.0402288649428402 0.61324719754995 0.882352941176471 27.2 27 2 abnormal embryonic-extraembryonic boundary morphology 0.00996220333860888 0.0402288649428402 0.61324719754995 0.882352941176471 27.2 27 2 increased regulatory T cell number 0.00996220333860888 0.0402288649428402 0.61324719754995 0.882352941176471 27.2 27 2 abnormal ectoplacental cone morphology 0.00996220333860888 0.0402288649428402 0.61324719754995 0.882352941176471 27.2 27 2 abnormal tarsal bone morphology 0.00996220333860888 0.0402288649428402 0.61324719754995 0.882352941176471 27.2 27 2 decreased growth hormone level 0.00996220333860888 0.0402288649428402 0.61324719754995 0.882352941176471 27.2 27 2 enhanced behavioral response to cocaine 0.00996220333860888 0.0402288649428402 0.61324719754995 0.882352941176471 27.2 27 2 common atrium 0.00996220333860888 0.0402288649428402 0.61324719754995 0.882352941176471 27.2 27 2 lethargy 6.36903884860677e-10 1.48760414421684e-08 0.612807593824108 0.881720430107527 27.2 27 2 increased hemoglobin content 9.68308096585435e-07 1.25125526766559e-05 0.612554262863453 0.88135593220339 27.2 27 2 increased insulin sensitivity 1.76749790131395e-14 8.2180393075111e-13 0.612389509161769 0.881118881118881 27.2 27 2 skin edema 3.9545635169452e-05 0.000342310518098529 0.612273789299871 0.880952380952381 27.2 27 2 abnormal muscle morphology 3.9545635169452e-05 0.000342310518098529 0.612273789299871 0.880952380952381 27.2 27 2 decreased heart rate 1.89337110335865e-10 4.78148286254278e-09 0.611611871689817 0.88 27.2 27 2 abnormal axon extension 7.54039087275935e-06 7.86445379286745e-05 0.611611871689817 0.88 27.2 27 2 decreased oocyte number 7.54039087275935e-06 7.86445379286745e-05 0.611611871689817 0.88 27.2 27 2 abnormal keratinocyte physiology 0.00173917129671207 0.00955008521097413 0.611611871689817 0.88 27.2 27 2 impaired conditioned place preference behavior 0.00173917129671207 0.00955008521097413 0.611611871689817 0.88 27.2 27 2 increased liver glycogen level 0.00173917129671207 0.00955008521097413 0.611611871689817 0.88 27.2 27 2 abnormal neurocranium morphology 3.68889883480969e-08 6.1174239010594e-07 0.611611871689817 0.88 27.2 27 2 increased grip strength 1.43216622016745e-09 3.16667864237025e-08 0.611000870818998 0.879120879120879 27.2 27 2 decreased circulating serum albumin level 2.83557068120818e-10 7.01839011891079e-09 0.610769431095203 0.878787878787879 27.2 27 2 abnormal vascular development 2.82586050596303e-07 3.98262210118019e-06 0.610769431095203 0.878787878787879 27.2 27 2 abnormal tail morphology 2.82586050596303e-07 3.98262210118019e-06 0.610769431095203 0.878787878787879 27.2 27 2 abnormal tooth development 0.000317380069962743 0.00218089205533791 0.610769431095203 0.878787878787879 27.2 27 2 belly spot 0.000317380069962743 0.00218089205533791 0.610769431095203 0.878787878787879 27.2 27 2 abnormal angiogenesis 5.5269823114208e-08 8.92751201276574e-07 0.610484822786212 0.878378378378378 27.2 27 2 sparse hair 1.08623143888977e-08 2.07846208018331e-07 0.610255747805804 0.878048780487805 27.2 27 2 abnormal developmental patterning 1.08623143888977e-08 2.07846208018331e-07 0.610255747805804 0.878048780487805 27.2 27 2 abnormal mammary gland development 5.94193510025056e-05 0.000493507965338005 0.610255747805804 0.878048780487805 27.2 27 2 arrested B cell differentiation 5.94193510025056e-05 0.000493507965338005 0.610255747805804 0.878048780487805 27.2 27 2 thin ventricular wall 2.1430022390162e-09 4.67606848206385e-08 0.610067397266358 0.877777777777778 27.2 27 2 increased anxiety-related response 8.88139429104767e-14 3.62171611458706e-12 0.610011840632421 0.877697841726619 27.2 27 2 increased T cell derived lymphoma incidence 1.13104323479301e-05 0.000112538801861905 0.609909797835393 0.877551020408163 27.2 27 2 abnormal craniofacial development 1.13104323479301e-05 0.000112538801861905 0.609909797835393 0.877551020408163 27.2 27 2 extramedullary hematopoiesis 8.41400418159052e-11 2.25051993566736e-09 0.609775986997781 0.877358490566038 27.2 27 2 abnormal liver morphology 2.85258953937908e-17 1.79640923524189e-15 0.609592838085965 0.877094972067039 27.2 27 2 thymus hypoplasia 1.32651375559596e-13 5.2376237572142e-12 0.609395886647463 0.876811594202899 27.2 27 2 decreased percent body fat/body weight 8.26642766088462e-08 1.30972858639812e-06 0.609326895830453 0.876712328767123 27.2 27 2 abnormal skeleton development 1.62370602564643e-08 2.9481523640843e-07 0.609209355919992 0.876543209876543 27.2 27 2 abnormal muscle physiology 3.20193729958584e-09 6.80753763480324e-08 0.609112946779951 0.876404494382023 27.2 27 2 abnormal cardiovascular system morphology 1.69218972393606e-05 0.000160050263813344 0.608136804237034 0.875 27.2 27 2 failure of primitive streak formation 0.000476349924967629 0.00310595134562773 0.608136804237034 0.875 27.2 27 2 abnormal spongiotrophoblast layer morphology 0.000476349924967629 0.00310595134562773 0.608136804237034 0.875 27.2 27 2 abnormal auditory brainstem response waveform shape 0.000476349924967629 0.00310595134562773 0.608136804237034 0.875 27.2 27 2 abnormal adrenal gland morphology 0.00261809299045138 0.0134417054979315 0.608136804237034 0.875 27.2 27 2 apnea 0.00261809299045138 0.0134417054979315 0.608136804237034 0.875 27.2 27 2 abnormal cardiac muscle contractility 0.00261809299045138 0.0134417054979315 0.608136804237034 0.875 27.2 27 2 abnormal tumor morphology 0.00261809299045138 0.0134417054979315 0.608136804237034 0.875 27.2 27 2 abnormal retinal ganglion layer morphology 0.00261809299045138 0.0134417054979315 0.608136804237034 0.875 27.2 27 2 abnormal lung saccule morphology 0.00261809299045138 0.0134417054979315 0.608136804237034 0.875 27.2 27 2 abnormal mouth morphology 0.0150777237824093 0.0553591703450083 0.608136804237034 0.875 27.2 27 2 abnormal extraembryonic endoderm formation 0.0150777237824093 0.0553591703450083 0.608136804237034 0.875 27.2 27 2 increased intestinal adenocarcinoma incidence 0.0150777237824093 0.0553591703450083 0.608136804237034 0.875 27.2 27 2 abnormal pulmonary elastic fiber morphology 0.0150777237824093 0.0553591703450083 0.608136804237034 0.875 27.2 27 2 small pancreas 0.0150777237824093 0.0553591703450083 0.608136804237034 0.875 27.2 27 2 bowed tibia 0.0150777237824093 0.0553591703450083 0.608136804237034 0.875 27.2 27 2 bowed radius 0.0150777237824093 0.0553591703450083 0.608136804237034 0.875 27.2 27 2 blepharitis 0.0150777237824093 0.0553591703450083 0.608136804237034 0.875 27.2 27 2 loose skin 0.0150777237824093 0.0553591703450083 0.608136804237034 0.875 27.2 27 2 decreased creatinine clearance 0.0150777237824093 0.0553591703450083 0.608136804237034 0.875 27.2 27 2 impaired behavioral response to addictive substance 0.0150777237824093 0.0553591703450083 0.608136804237034 0.875 27.2 27 2 decreased liver cholesterol level 0.0150777237824093 0.0553591703450083 0.608136804237034 0.875 27.2 27 2 decreased skeletal muscle weight 0.0150777237824093 0.0553591703450083 0.608136804237034 0.875 27.2 27 2 embryonic lethality between somite formation and embryo turning, incomplete penetrance 0.0150777237824093 0.0553591703450083 0.608136804237034 0.875 27.2 27 2 decreased adipocyte glucose uptake 0.0150777237824093 0.0553591703450083 0.608136804237034 0.875 27.2 27 2 abnormal bone marrow development 0.0962510107339877 0.229114248039038 0.608136804237034 0.875 27.2 27 2 schistocytosis 0.0962510107339877 0.229114248039038 0.608136804237034 0.875 27.2 27 2 pointed snout 0.0962510107339877 0.229114248039038 0.608136804237034 0.875 27.2 27 2 abnormal esophageal epithelium morphology 0.0962510107339877 0.229114248039038 0.608136804237034 0.875 27.2 27 2 clubfoot 0.0962510107339877 0.229114248039038 0.608136804237034 0.875 27.2 27 2 absent mammary gland 0.0962510107339877 0.229114248039038 0.608136804237034 0.875 27.2 27 2 enlarged pituitary gland 0.0962510107339877 0.229114248039038 0.608136804237034 0.875 27.2 27 2 absent skin pigmentation 0.0962510107339877 0.229114248039038 0.608136804237034 0.875 27.2 27 2 increased sensitivity to skin irradiation 0.0962510107339877 0.229114248039038 0.608136804237034 0.875 27.2 27 2 dermal cysts 0.0962510107339877 0.229114248039038 0.608136804237034 0.875 27.2 27 2 abnormal pupil morphology 0.0962510107339877 0.229114248039038 0.608136804237034 0.875 27.2 27 2 poor grooming 0.0962510107339877 0.229114248039038 0.608136804237034 0.875 27.2 27 2 abnormal erythrocyte cell number 0.0962510107339877 0.229114248039038 0.608136804237034 0.875 27.2 27 2 abnormal atrial thrombosis 0.0962510107339877 0.229114248039038 0.608136804237034 0.875 27.2 27 2 preneoplasia 0.0962510107339877 0.229114248039038 0.608136804237034 0.875 27.2 27 2 abnormal secondary sex determination 0.0962510107339877 0.229114248039038 0.608136804237034 0.875 27.2 27 2 abnormal pulmonary circulation 0.0962510107339877 0.229114248039038 0.608136804237034 0.875 27.2 27 2 coarse hair 0.0962510107339877 0.229114248039038 0.608136804237034 0.875 27.2 27 2 abnormal thyroid physiology 0.0962510107339877 0.229114248039038 0.608136804237034 0.875 27.2 27 2 abnormal muscle precursor cell migration 0.0962510107339877 0.229114248039038 0.608136804237034 0.875 27.2 27 2 decreased corneal stroma thickness 0.0962510107339877 0.229114248039038 0.608136804237034 0.875 27.2 27 2 absent tympanic ring 0.0962510107339877 0.229114248039038 0.608136804237034 0.875 27.2 27 2 abnormal cellular cholesterol metabolism 0.0962510107339877 0.229114248039038 0.608136804237034 0.875 27.2 27 2 calcified muscle 0.0962510107339877 0.229114248039038 0.608136804237034 0.875 27.2 27 2 abnormal neuron apoptosis 0.0962510107339877 0.229114248039038 0.608136804237034 0.875 27.2 27 2 decreased susceptibility to age related obesity 0.0962510107339877 0.229114248039038 0.608136804237034 0.875 27.2 27 2 liver failure 0.0962510107339877 0.229114248039038 0.608136804237034 0.875 27.2 27 2 increased cardiac output 0.0962510107339877 0.229114248039038 0.608136804237034 0.875 27.2 27 2 increased left ventricle systolic pressure 0.0962510107339877 0.229114248039038 0.608136804237034 0.875 27.2 27 2 abnormal forelimb zeugopod morphology 0.0962510107339877 0.229114248039038 0.608136804237034 0.875 27.2 27 2 lymph node inflammation 0.0962510107339877 0.229114248039038 0.608136804237034 0.875 27.2 27 2 abnormal gastric gland morphology 0.0962510107339877 0.229114248039038 0.608136804237034 0.875 27.2 27 2 abnormal skin development 0.0962510107339877 0.229114248039038 0.608136804237034 0.875 27.2 27 2 long femur 0.0962510107339877 0.229114248039038 0.608136804237034 0.875 27.2 27 2 small frontal bone 0.0962510107339877 0.229114248039038 0.608136804237034 0.875 27.2 27 2 abnormal hair follicle melanocyte morphology 0.0962510107339877 0.229114248039038 0.608136804237034 0.875 27.2 27 2 absent interparietal bone 0.0962510107339877 0.229114248039038 0.608136804237034 0.875 27.2 27 2 absent cochlear microphonics 0.0962510107339877 0.229114248039038 0.608136804237034 0.875 27.2 27 2 abnormal vestibular labyrinth morphology 0.0962510107339877 0.229114248039038 0.608136804237034 0.875 27.2 27 2 increased epididymis weight 0.0962510107339877 0.229114248039038 0.608136804237034 0.875 27.2 27 2 ectrodactyly 0.0962510107339877 0.229114248039038 0.608136804237034 0.875 27.2 27 2 abnormal olfactory tract morphology 0.0962510107339877 0.229114248039038 0.608136804237034 0.875 27.2 27 2 Sertoli cell hypoplasia 0.0962510107339877 0.229114248039038 0.608136804237034 0.875 27.2 27 2 abnormal circulating corticosterone level 0.0962510107339877 0.229114248039038 0.608136804237034 0.875 27.2 27 2 abnormal ilium morphology 0.0962510107339877 0.229114248039038 0.608136804237034 0.875 27.2 27 2 stomach epithelial hyperplasia 0.0962510107339877 0.229114248039038 0.608136804237034 0.875 27.2 27 2 increased pulmonary ventilation 0.0962510107339877 0.229114248039038 0.608136804237034 0.875 27.2 27 2 absent outer ear 0.0962510107339877 0.229114248039038 0.608136804237034 0.875 27.2 27 2 impaired behavioral response to alcohol 0.0962510107339877 0.229114248039038 0.608136804237034 0.875 27.2 27 2 abnormal meiotic spindle morphology 0.0962510107339877 0.229114248039038 0.608136804237034 0.875 27.2 27 2 abnormal base-excision repair 0.0962510107339877 0.229114248039038 0.608136804237034 0.875 27.2 27 2 abnormal sphingomyelin level 0.0962510107339877 0.229114248039038 0.608136804237034 0.875 27.2 27 2 abnormal frontonasal prominence morphology 0.0962510107339877 0.229114248039038 0.608136804237034 0.875 27.2 27 2 abnormal olfactory bulb mitral cell layer morphology 0.0962510107339877 0.229114248039038 0.608136804237034 0.875 27.2 27 2 decreased hippocampus pyramidal cell number 0.0962510107339877 0.229114248039038 0.608136804237034 0.875 27.2 27 2 abnormal lateral plate mesoderm morphology 0.0962510107339877 0.229114248039038 0.608136804237034 0.875 27.2 27 2 ostium secundum atrial septal defect 0.0962510107339877 0.229114248039038 0.608136804237034 0.875 27.2 27 2 lung situs inversus 0.0962510107339877 0.229114248039038 0.608136804237034 0.875 27.2 27 2 abnormal bronchiole epithelium morphology 0.0962510107339877 0.229114248039038 0.608136804237034 0.875 27.2 27 2 abnormal pulmonary acinus morphology 0.0962510107339877 0.229114248039038 0.608136804237034 0.875 27.2 27 2 increased airway resistance 0.0962510107339877 0.229114248039038 0.608136804237034 0.875 27.2 27 2 abnormal kidney mesenchyme morphology 0.0962510107339877 0.229114248039038 0.608136804237034 0.875 27.2 27 2 increased aorta wall thickness 0.0962510107339877 0.229114248039038 0.608136804237034 0.875 27.2 27 2 increased cardiac stroke volume 0.0962510107339877 0.229114248039038 0.608136804237034 0.875 27.2 27 2 increased brain apoptosis 0.0962510107339877 0.229114248039038 0.608136804237034 0.875 27.2 27 2 decreased basal metabolism 0.0962510107339877 0.229114248039038 0.608136804237034 0.875 27.2 27 2 decreased vascular endothelial cell proliferation 0.0962510107339877 0.229114248039038 0.608136804237034 0.875 27.2 27 2 decreased circulating cholesterol level 2.82577948573256e-17 1.79640923524189e-15 0.607662068246217 0.87431693989071 27.2 27 2 impaired righting response 1.40715395003286e-09 3.12526379527387e-08 0.607222312802091 0.873684210526316 27.2 27 2 hunched posture 3.61013007767473e-08 6.04727176310834e-07 0.607037099346913 0.873417721518987 27.2 27 2 decreased B cell proliferation 3.61013007767473e-08 6.04727176310834e-07 0.607037099346913 0.873417721518987 27.2 27 2 atelectasis 1.83910999311184e-07 2.67531351337175e-06 0.606913188936758 0.873239436619718 27.2 27 2 abnormal rostral-caudal axis patterning 4.85486819694989e-06 5.34020031146405e-05 0.606557228122133 0.872727272727273 27.2 27 2 abnormal extraembryonic tissue morphology 4.14970135550337e-10 9.97331605972429e-09 0.606433339799395 0.872549019607843 27.2 27 2 abnormal tibia morphology 2.5249751671811e-05 0.000230068707998644 0.606288364102575 0.872340425531915 27.2 27 2 neuron degeneration 2.5249751671811e-05 0.000230068707998644 0.606288364102575 0.872340425531915 27.2 27 2 decreased bone trabecula number 2.5249751671811e-05 0.000230068707998644 0.606288364102575 0.872340425531915 27.2 27 2 increased oxygen consumption 1.05828147193457e-08 2.0486188026749e-07 0.606116416183091 0.872093023255814 27.2 27 2 abnormal iris morphology 0.000132928516718301 0.00103492859260336 0.605909196895506 0.871794871794872 27.2 27 2 abnormal action potential 2.73541296719351e-07 3.87711667002499e-06 0.605654613199332 0.871428571428571 27.2 27 2 abnormal cranial ganglia morphology 0.000712219767119896 0.00440708127042473 0.60533433048479 0.870967741935484 27.2 27 2 abnormal capillary morphology 0.000712219767119896 0.00440708127042473 0.60533433048479 0.870967741935484 27.2 27 2 abnormal retinal photoreceptor layer morphology 0.000712219767119896 0.00440708127042473 0.60533433048479 0.870967741935484 27.2 27 2 decreased double-negative T cell number 0.000712219767119896 0.00440708127042473 0.60533433048479 0.870967741935484 27.2 27 2 abnormal mitochondrial ATP synthesis coupled electron transport 0.000712219767119896 0.00440708127042473 0.60533433048479 0.870967741935484 27.2 27 2 circling 1.57139201138954e-08 2.87414531494962e-07 0.605070568249284 0.870588235294118 27.2 27 2 abnormal bone structure 1.22150366266913e-17 8.32463112572458e-16 0.604985836339433 0.870466321243523 27.2 27 2 abnormal cochlea morphology 7.22249607179056e-06 7.56461430677012e-05 0.604919149188161 0.87037037037037 27.2 27 2 diluted coat color 7.22249607179056e-06 7.56461430677012e-05 0.604919149188161 0.87037037037037 27.2 27 2 abnormal mandible morphology 7.22249607179056e-06 7.56461430677012e-05 0.604919149188161 0.87037037037037 27.2 27 2 abnormal apoptosis 7.22249607179056e-06 7.56461430677012e-05 0.604919149188161 0.87037037037037 27.2 27 2 decreased hematocrit 1.2673279572741e-13 5.06029565203537e-12 0.604566529456777 0.86986301369863 27.2 27 2 abnormal testis morphology 5.36310587286979e-11 1.47411335455951e-09 0.604359557005748 0.869565217391304 27.2 27 2 abnormal sternum morphology 4.0605678906305e-07 5.61147923774631e-06 0.604359557005748 0.869565217391304 27.2 27 2 abnormal inner ear morphology 3.75711223355174e-05 0.00032849970759086 0.604359557005748 0.869565217391304 27.2 27 2 atrial septal defect 3.75711223355174e-05 0.00032849970759086 0.604359557005748 0.869565217391304 27.2 27 2 fragile skeleton 0.00392203491005437 0.0189622193173183 0.604359557005748 0.869565217391304 27.2 27 2 abnormal blood vessel physiology 0.00392203491005437 0.0189622193173183 0.604359557005748 0.869565217391304 27.2 27 2 abnormal cranial nerve morphology 0.00392203491005437 0.0189622193173183 0.604359557005748 0.869565217391304 27.2 27 2 hypotension 0.00392203491005437 0.0189622193173183 0.604359557005748 0.869565217391304 27.2 27 2 abnormal cochlear ganglion morphology 0.00392203491005437 0.0189622193173183 0.604359557005748 0.869565217391304 27.2 27 2 abnormal ulna morphology 0.00392203491005437 0.0189622193173183 0.604359557005748 0.869565217391304 27.2 27 2 abnormal corneal stroma morphology 0.00392203491005437 0.0189622193173183 0.604359557005748 0.869565217391304 27.2 27 2 abnormal hematopoietic stem cell physiology 0.00392203491005437 0.0189622193173183 0.604359557005748 0.869565217391304 27.2 27 2 decreased effector memory CD8-positive, alpha-beta T cell number 0.00392203491005437 0.0189622193173183 0.604359557005748 0.869565217391304 27.2 27 2 decreased leukocyte cell number 9.36990604829988e-13 3.19155535190209e-11 0.603697849461581 0.868613138686131 27.2 27 2 decreased neuron apoptosis 0.000197854367762416 0.00145395196398526 0.60356434706232 0.868421052631579 27.2 27 2 small spleen 6.82267269643708e-09 1.37420229412042e-07 0.603363359933761 0.868131868131868 27.2 27 2 abnormal coat/ hair morphology 1.07179064484675e-05 0.000107503194720011 0.603219255954794 0.867924528301887 27.2 27 2 increased circulating bilirubin level 1.07179064484675e-05 0.000107503194720011 0.603219255954794 0.867924528301887 27.2 27 2 cataract 2.34278469151458e-11 6.8560904942853e-10 0.603110880235075 0.867768595041322 27.2 27 2 cardiac hypertrophy 2.00214935444162e-09 4.38797050147448e-08 0.602817823441958 0.86734693877551 27.2 27 2 anemia 1.03963179376034e-18 8.76638673552147e-17 0.602784212188909 0.867298578199052 27.2 27 2 increased circulating HDL cholesterol level 5.88503468028988e-10 1.38758519120579e-08 0.602345025149062 0.866666666666667 27.2 27 2 increased circulating corticosterone level 5.57426800585434e-05 0.000469238296601106 0.602345025149062 0.866666666666667 27.2 27 2 liver hemorrhage 0.00106056923990324 0.00619287789732235 0.602345025149062 0.866666666666667 27.2 27 2 decreased chondrocyte number 0.0226660910544124 0.0789662485964299 0.602345025149062 0.866666666666667 27.2 27 2 macrocytosis 0.0226660910544124 0.0789662485964299 0.602345025149062 0.866666666666667 27.2 27 2 interdigital webbing 0.0226660910544124 0.0789662485964299 0.602345025149062 0.866666666666667 27.2 27 2 no suckling reflex 0.0226660910544124 0.0789662485964299 0.602345025149062 0.866666666666667 27.2 27 2 placental labyrinth hypoplasia 0.0226660910544124 0.0789662485964299 0.602345025149062 0.866666666666667 27.2 27 2 abnormal lymph node B cell domain morphology 0.0226660910544124 0.0789662485964299 0.602345025149062 0.866666666666667 27.2 27 2 altered righting response 0.0226660910544124 0.0789662485964299 0.602345025149062 0.866666666666667 27.2 27 2 abnormal pericyte morphology 0.0226660910544124 0.0789662485964299 0.602345025149062 0.866666666666667 27.2 27 2 abnormal placenta size 0.0226660910544124 0.0789662485964299 0.602345025149062 0.866666666666667 27.2 27 2 abnormal rostral migratory stream morphology 0.0226660910544124 0.0789662485964299 0.602345025149062 0.866666666666667 27.2 27 2 abnormal trophectoderm morphology 0.0226660910544124 0.0789662485964299 0.602345025149062 0.866666666666667 27.2 27 2 abnormal zygomatic bone morphology 0.0226660910544124 0.0789662485964299 0.602345025149062 0.866666666666667 27.2 27 2 abnormal energy homeostasis 0.0226660910544124 0.0789662485964299 0.602345025149062 0.866666666666667 27.2 27 2 abnormal Muller cell morphology 0.0226660910544124 0.0789662485964299 0.602345025149062 0.866666666666667 27.2 27 2 decreased thymocyte apoptosis 0.0226660910544124 0.0789662485964299 0.602345025149062 0.866666666666667 27.2 27 2 absent chorion 0.0226660910544124 0.0789662485964299 0.602345025149062 0.866666666666667 27.2 27 2 liver vascular congestion 0.0226660910544124 0.0789662485964299 0.602345025149062 0.866666666666667 27.2 27 2 bicuspid aortic valve 0.0226660910544124 0.0789662485964299 0.602345025149062 0.866666666666667 27.2 27 2 abnormal coronary vessel morphology 0.0226660910544124 0.0789662485964299 0.602345025149062 0.866666666666667 27.2 27 2 decreased brown adipose tissue mass 0.0226660910544124 0.0789662485964299 0.602345025149062 0.866666666666667 27.2 27 2 decreased compact bone thickness 8.89323457135484e-07 1.16125569534095e-05 0.601653469437066 0.865671641791045 27.2 27 2 abnormal lung morphology 5.10484614025184e-11 1.42890962732779e-09 0.601566298548999 0.865546218487395 27.2 27 2 increased brown adipose tissue amount 0.000293470097998405 0.00204770510174202 0.601092748589501 0.864864864864865 27.2 27 2 abnormal long bone metaphysis morphology 0.000293470097998405 0.00204770510174202 0.601092748589501 0.864864864864865 27.2 27 2 abnormal hair follicle development 0.000293470097998405 0.00204770510174202 0.601092748589501 0.864864864864865 27.2 27 2 decreased B cell number 7.24379097400775e-18 5.07575494305473e-16 0.600545637471246 0.864077669902913 27.2 27 2 insulin resistance 6.54404626269741e-12 2.00966852820491e-10 0.600238923662527 0.863636363636364 27.2 27 2 osteoporosis 8.24522136764818e-05 0.000664829437666932 0.600238923662527 0.863636363636364 27.2 27 2 abnormal myelopoiesis 8.24522136764818e-05 0.000664829437666932 0.600238923662527 0.863636363636364 27.2 27 2 renal interstitial fibrosis 8.24522136764818e-05 0.000664829437666932 0.600238923662527 0.863636363636364 27.2 27 2 abnormal enterocyte morphology 0.00584446921499852 0.0258685358937879 0.600238923662527 0.863636363636364 27.2 27 2 increased body size 0.00584446921499852 0.0258685358937879 0.600238923662527 0.863636363636364 27.2 27 2 testis hypoplasia 0.00584446921499852 0.0258685358937879 0.600238923662527 0.863636363636364 27.2 27 2 aphakia 0.00584446921499852 0.0258685358937879 0.600238923662527 0.863636363636364 27.2 27 2 decreased cardiac output 0.00584446921499852 0.0258685358937879 0.600238923662527 0.863636363636364 27.2 27 2 abnormal channel response 0.00584446921499852 0.0258685358937879 0.600238923662527 0.863636363636364 27.2 27 2 abnormal retinal outer plexiform layer morphology 0.00584446921499852 0.0258685358937879 0.600238923662527 0.863636363636364 27.2 27 2 abnormal basement membrane morphology 0.00584446921499852 0.0258685358937879 0.600238923662527 0.863636363636364 27.2 27 2 abnormal mesenteric lymph node morphology 0.00584446921499852 0.0258685358937879 0.600238923662527 0.863636363636364 27.2 27 2 pulmonary vascular congestion 0.00584446921499852 0.0258685358937879 0.600238923662527 0.863636363636364 27.2 27 2 increased adenoma incidence 0.00584446921499852 0.0258685358937879 0.600238923662527 0.863636363636364 27.2 27 2 alopecia 6.41752916751643e-09 1.2978539678209e-07 0.599906381322548 0.863157894736842 27.2 27 2 abnormal seminiferous tubule morphology 5.71236489970323e-13 2.04453348028947e-11 0.599806163083102 0.863013698630137 27.2 27 2 distended abdomen 2.34167685203098e-05 0.000216943060313857 0.59961948204884 0.862745098039216 27.2 27 2 increased lung adenocarcinoma incidence 2.34167685203098e-05 0.000216943060313857 0.59961948204884 0.862745098039216 27.2 27 2 abnormal retinal pigment epithelium morphology 1.10557344696686e-07 1.7081453101429e-06 0.599449135605076 0.8625 27.2 27 2 abnormal middle ear morphology 0.00157248559855633 0.00879001781215478 0.599149560824664 0.862068965517241 27.2 27 2 abnormal microglial cell morphology 0.00157248559855633 0.00879001781215478 0.599149560824664 0.862068965517241 27.2 27 2 focal hair loss 0.00157248559855633 0.00879001781215478 0.599149560824664 0.862068965517241 27.2 27 2 decreased bone strength 0.00157248559855633 0.00879001781215478 0.599149560824664 0.862068965517241 27.2 27 2 increased double-positive T cell number 0.00157248559855633 0.00879001781215478 0.599149560824664 0.862068965517241 27.2 27 2 abnormal retina morphology 6.82097299976488e-18 4.84776295340432e-16 0.599035437098793 0.861904761904762 27.2 27 2 abnormal heart left ventricle morphology 5.58991275851374e-07 7.59831037530214e-06 0.598483839090414 0.861111111111111 27.2 27 2 abnormal reflex 0.000433703036558642 0.00287689680917233 0.598483839090414 0.861111111111111 27.2 27 2 hypoglycemia 1.38420190256686e-08 2.59864319444155e-07 0.597861067145471 0.860215053763441 27.2 27 2 abnormal definitive hematopoiesis 1.38420190256686e-08 2.59864319444155e-07 0.597861067145471 0.860215053763441 27.2 27 2 kidney inflammation 3.44692585525512e-05 0.000303512497874234 0.597711601878685 0.86 27.2 27 2 abnormal facial morphology 9.85552607110958e-06 9.92535267282797e-05 0.597467737496034 0.859649122807018 27.2 27 2 decreased caudal vertebrae number 2.83611436677955e-06 3.34352345372707e-05 0.597277218447087 0.859375 27.2 27 2 abnormal osteoclast physiology 2.83611436677955e-06 3.34352345372707e-05 0.597277218447087 0.859375 27.2 27 2 abnormal tooth morphology 2.83611436677955e-06 3.34352345372707e-05 0.597277218447087 0.859375 27.2 27 2 corneal opacity 8.20286110909189e-07 1.07392721099295e-05 0.597124266534553 0.859154929577465 27.2 27 2 decreased liver weight 8.20286110909189e-07 1.07392721099295e-05 0.597124266534553 0.859154929577465 27.2 27 2 abnormal cornea morphology 2.38215745377377e-07 3.43514009638392e-06 0.596998767529396 0.858974358974359 27.2 27 2 abnormal spermatogenesis 1.77118825314402e-15 9.68314457075988e-14 0.596805062543176 0.858695652173913 27.2 27 2 increased circulating aspartate transaminase level 4.15542150219751e-06 4.66664152899156e-05 0.595725849048523 0.857142857142857 27.2 27 2 disheveled coat 0.000178661646000825 0.00133259623516358 0.595725849048523 0.857142857142857 27.2 27 2 abnormal spleen white pulp morphology 0.000178661646000825 0.00133259623516358 0.595725849048523 0.857142857142857 27.2 27 2 increased incidence of induced tumors 0.00865937989785802 0.0354571316805298 0.595725849048523 0.857142857142857 27.2 27 2 left pulmonary isomerism 0.00865937989785802 0.0354571316805298 0.595725849048523 0.857142857142857 27.2 27 2 decreased cochlear outer hair cell number 0.00865937989785802 0.0354571316805298 0.595725849048523 0.857142857142857 27.2 27 2 complete atrioventricular septal defect 0.00865937989785802 0.0354571316805298 0.595725849048523 0.857142857142857 27.2 27 2 embryonic lethality at implantation, complete penetrance 0.00865937989785802 0.0354571316805298 0.595725849048523 0.857142857142857 27.2 27 2 lymphoid hyperplasia 0.00232076512523976 0.0122566947962503 0.595725849048523 0.857142857142857 27.2 27 2 small superior cervical ganglion 0.00232076512523976 0.0122566947962503 0.595725849048523 0.857142857142857 27.2 27 2 reddish skin 0.00232076512523976 0.0122566947962503 0.595725849048523 0.857142857142857 27.2 27 2 abnormal respiration 0.00232076512523976 0.0122566947962503 0.595725849048523 0.857142857142857 27.2 27 2 enhanced coordination 0.00232076512523976 0.0122566947962503 0.595725849048523 0.857142857142857 27.2 27 2 abnormal renal tubule epithelium morphology 0.00232076512523976 0.0122566947962503 0.595725849048523 0.857142857142857 27.2 27 2 megacephaly 0.0338152471246142 0.10694904923392 0.595725849048523 0.857142857142857 27.2 27 2 abnormal pinna reflex 0.0338152471246142 0.10694904923392 0.595725849048523 0.857142857142857 27.2 27 2 extended life span 0.0338152471246142 0.10694904923392 0.595725849048523 0.857142857142857 27.2 27 2 abnormal adrenal gland secretion 0.0338152471246142 0.10694904923392 0.595725849048523 0.857142857142857 27.2 27 2 abnormal spleen periarteriolar lymphoid sheath morphology 0.0338152471246142 0.10694904923392 0.595725849048523 0.857142857142857 27.2 27 2 abnormal endplate potential 0.0338152471246142 0.10694904923392 0.595725849048523 0.857142857142857 27.2 27 2 absent otoliths 0.0338152471246142 0.10694904923392 0.595725849048523 0.857142857142857 27.2 27 2 intestinal obstruction 0.0338152471246142 0.10694904923392 0.595725849048523 0.857142857142857 27.2 27 2 failure of zygotic cell division 0.0338152471246142 0.10694904923392 0.595725849048523 0.857142857142857 27.2 27 2 skeletal muscle necrosis 0.0338152471246142 0.10694904923392 0.595725849048523 0.857142857142857 27.2 27 2 abnormal glucose tolerance 0.0338152471246142 0.10694904923392 0.595725849048523 0.857142857142857 27.2 27 2 spina bifida occulta 0.0338152471246142 0.10694904923392 0.595725849048523 0.857142857142857 27.2 27 2 sternebra fusion 0.0338152471246142 0.10694904923392 0.595725849048523 0.857142857142857 27.2 27 2 increased lung compliance 0.0338152471246142 0.10694904923392 0.595725849048523 0.857142857142857 27.2 27 2 decreased compact bone area 0.0338152471246142 0.10694904923392 0.595725849048523 0.857142857142857 27.2 27 2 absent endolymphatic duct 0.145876062481581 0.300386345548786 0.595725849048523 0.857142857142857 27.2 27 2 cellular necrosis 0.145876062481581 0.300386345548786 0.595725849048523 0.857142857142857 27.2 27 2 polyphalangy 0.145876062481581 0.300386345548786 0.595725849048523 0.857142857142857 27.2 27 2 maxilla hypoplasia 0.145876062481581 0.300386345548786 0.595725849048523 0.857142857142857 27.2 27 2 abnormal foot pad morphology 0.145876062481581 0.300386345548786 0.595725849048523 0.857142857142857 27.2 27 2 small L4 dorsal root ganglion 0.145876062481581 0.300386345548786 0.595725849048523 0.857142857142857 27.2 27 2 abnormal oculomotor nerve morphology 0.145876062481581 0.300386345548786 0.595725849048523 0.857142857142857 27.2 27 2 decreased Schwann cell number 0.145876062481581 0.300386345548786 0.595725849048523 0.857142857142857 27.2 27 2 prostate gland epithelial hyperplasia 0.145876062481581 0.300386345548786 0.595725849048523 0.857142857142857 27.2 27 2 abnormal lacrimal gland morphology 0.145876062481581 0.300386345548786 0.595725849048523 0.857142857142857 27.2 27 2 abnormal liquid preference 0.145876062481581 0.300386345548786 0.595725849048523 0.857142857142857 27.2 27 2 limp posture 0.145876062481581 0.300386345548786 0.595725849048523 0.857142857142857 27.2 27 2 abnormal circulating free fatty acids level 0.145876062481581 0.300386345548786 0.595725849048523 0.857142857142857 27.2 27 2 abnormal axial mesoderm 0.145876062481581 0.300386345548786 0.595725849048523 0.857142857142857 27.2 27 2 absent amniotic folds 0.145876062481581 0.300386345548786 0.595725849048523 0.857142857142857 27.2 27 2 decreased activated T cell number 0.145876062481581 0.300386345548786 0.595725849048523 0.857142857142857 27.2 27 2 increased colonic adenoma incidence 0.145876062481581 0.300386345548786 0.595725849048523 0.857142857142857 27.2 27 2 abnormal gastrulation movements 0.145876062481581 0.300386345548786 0.595725849048523 0.857142857142857 27.2 27 2 increased retinal ganglion cell number 0.145876062481581 0.300386345548786 0.595725849048523 0.857142857142857 27.2 27 2 abnormal superior semicircular canal morphology 0.145876062481581 0.300386345548786 0.595725849048523 0.857142857142857 27.2 27 2 detached tectorial membrane 0.145876062481581 0.300386345548786 0.595725849048523 0.857142857142857 27.2 27 2 absent tunnel of Corti 0.145876062481581 0.300386345548786 0.595725849048523 0.857142857142857 27.2 27 2 decreased cholesterol efflux 0.145876062481581 0.300386345548786 0.595725849048523 0.857142857142857 27.2 27 2 anuria 0.145876062481581 0.300386345548786 0.595725849048523 0.857142857142857 27.2 27 2 skeletal muscle interstitial fibrosis 0.145876062481581 0.300386345548786 0.595725849048523 0.857142857142857 27.2 27 2 abnormal nephron morphology 0.145876062481581 0.300386345548786 0.595725849048523 0.857142857142857 27.2 27 2 increased ectoderm apoptosis 0.145876062481581 0.300386345548786 0.595725849048523 0.857142857142857 27.2 27 2 abnormal strial marginal cell morphology 0.145876062481581 0.300386345548786 0.595725849048523 0.857142857142857 27.2 27 2 absent endocochlear potential 0.145876062481581 0.300386345548786 0.595725849048523 0.857142857142857 27.2 27 2 abnormal MHC II cell surface expression on macrophages 0.145876062481581 0.300386345548786 0.595725849048523 0.857142857142857 27.2 27 2 abnormal gallbladder morphology 0.145876062481581 0.300386345548786 0.595725849048523 0.857142857142857 27.2 27 2 abnormal talus morphology 0.145876062481581 0.300386345548786 0.595725849048523 0.857142857142857 27.2 27 2 increased adrenocorticotropin level 0.145876062481581 0.300386345548786 0.595725849048523 0.857142857142857 27.2 27 2 absent thyroid gland 0.145876062481581 0.300386345548786 0.595725849048523 0.857142857142857 27.2 27 2 atherosclerotic lesions 0.145876062481581 0.300386345548786 0.595725849048523 0.857142857142857 27.2 27 2 increased chronic myelocytic leukemia incidence 0.145876062481581 0.300386345548786 0.595725849048523 0.857142857142857 27.2 27 2 retinal pigment epithelium atrophy 0.145876062481581 0.300386345548786 0.595725849048523 0.857142857142857 27.2 27 2 abnormal renal filtration rate 0.145876062481581 0.300386345548786 0.595725849048523 0.857142857142857 27.2 27 2 increased keratinocyte apoptosis 0.145876062481581 0.300386345548786 0.595725849048523 0.857142857142857 27.2 27 2 uremia 0.145876062481581 0.300386345548786 0.595725849048523 0.857142857142857 27.2 27 2 abnormal spinal cord central canal morphology 0.145876062481581 0.300386345548786 0.595725849048523 0.857142857142857 27.2 27 2 enhanced behavioral response to alcohol 0.145876062481581 0.300386345548786 0.595725849048523 0.857142857142857 27.2 27 2 decreased behavioral withdrawal response 0.145876062481581 0.300386345548786 0.595725849048523 0.857142857142857 27.2 27 2 abnormal prostaglandin level 0.145876062481581 0.300386345548786 0.595725849048523 0.857142857142857 27.2 27 2 decreased DN4 thymocyte number 0.145876062481581 0.300386345548786 0.595725849048523 0.857142857142857 27.2 27 2 arteritis 0.145876062481581 0.300386345548786 0.595725849048523 0.857142857142857 27.2 27 2 focal dorsal hair loss 0.145876062481581 0.300386345548786 0.595725849048523 0.857142857142857 27.2 27 2 increased quadriceps weight 0.145876062481581 0.300386345548786 0.595725849048523 0.857142857142857 27.2 27 2 heart right ventricle outflow tract stenosis 0.145876062481581 0.300386345548786 0.595725849048523 0.857142857142857 27.2 27 2 coronary fistula 0.145876062481581 0.300386345548786 0.595725849048523 0.857142857142857 27.2 27 2 abnormal T wave 0.145876062481581 0.300386345548786 0.595725849048523 0.857142857142857 27.2 27 2 heart block 0.145876062481581 0.300386345548786 0.595725849048523 0.857142857142857 27.2 27 2 abnormal conotruncal ridge morphology 0.145876062481581 0.300386345548786 0.595725849048523 0.857142857142857 27.2 27 2 thick pulmonary valve 0.145876062481581 0.300386345548786 0.595725849048523 0.857142857142857 27.2 27 2 altered tumor pathology 0.145876062481581 0.300386345548786 0.595725849048523 0.857142857142857 27.2 27 2 abnormal impulsive behavior control 0.145876062481581 0.300386345548786 0.595725849048523 0.857142857142857 27.2 27 2 increased right ventricle systolic pressure 0.145876062481581 0.300386345548786 0.595725849048523 0.857142857142857 27.2 27 2 small lung saccule 0.145876062481581 0.300386345548786 0.595725849048523 0.857142857142857 27.2 27 2 increased compact bone volume 0.145876062481581 0.300386345548786 0.595725849048523 0.857142857142857 27.2 27 2 impaired branching involved in bronchus morphogenesis 0.145876062481581 0.300386345548786 0.595725849048523 0.857142857142857 27.2 27 2 embryonic lethality at implantation, incomplete penetrance 0.145876062481581 0.300386345548786 0.595725849048523 0.857142857142857 27.2 27 2 increased circulating lactate dehydrogenase level 0.145876062481581 0.300386345548786 0.595725849048523 0.857142857142857 27.2 27 2 impaired mammary gland growth during pregnancy 0.145876062481581 0.300386345548786 0.595725849048523 0.857142857142857 27.2 27 2 absent heart tube 0.145876062481581 0.300386345548786 0.595725849048523 0.857142857142857 27.2 27 2 dysmyelination 0.145876062481581 0.300386345548786 0.595725849048523 0.857142857142857 27.2 27 2 decreased volumetric bone mineral density 0.145876062481581 0.300386345548786 0.595725849048523 0.857142857142857 27.2 27 2 abnormal Mullerian duct topology 0.145876062481581 0.300386345548786 0.595725849048523 0.857142857142857 27.2 27 2 embryo tumor 0.145876062481581 0.300386345548786 0.595725849048523 0.857142857142857 27.2 27 2 no abnormal phenotype detected 3.68647255291626e-135 1.83402009507584e-131 0.595268038597765 0.856484149855908 27.2 27 2 abnormal spleen morphology 1.86352691376413e-14 8.58430221849681e-13 0.595155230419166 0.85632183908046 27.2 27 2 small testis 6.90493108679663e-22 6.87040643136265e-20 0.594286897722319 0.855072463768116 27.2 27 2 prenatal lethality 6.07372185556036e-06 6.49822929707801e-05 0.594124435475812 0.854838709677419 27.2 27 2 reduced male fertility 3.42921443353575e-18 2.58490027376369e-16 0.593976287083623 0.854625550660793 27.2 27 2 abnormal platelet physiology 2.11323098364797e-05 0.000196510731656984 0.593920619202922 0.854545454545454 27.2 27 2 Leydig cell hyperplasia 0.000261646023079591 0.00184375207481723 0.593304199255643 0.853658536585366 27.2 27 2 short ulna 0.000261646023079591 0.00184375207481723 0.593304199255643 0.853658536585366 27.2 27 2 increased bone trabecula number 0.000261646023079591 0.00184375207481723 0.593304199255643 0.853658536585366 27.2 27 2 spleen hyperplasia 7.4231477100714e-07 9.79579837071757e-06 0.593078178608307 0.853333333333333 27.2 27 2 overexpanded pulmonary alveoli 0.000936108701341054 0.00565186988977153 0.592805624298285 0.852941176470588 27.2 27 2 abnormal spleen red pulp morphology 0.000936108701341054 0.00565186988977153 0.592805624298285 0.852941176470588 27.2 27 2 abnormal small intestine morphology 3.08165161143596e-05 0.000272797451368219 0.592048528992668 0.851851851851852 27.2 27 2 abnormal osteoblast physiology 3.08165161143596e-05 0.000272797451368219 0.592048528992668 0.851851851851852 27.2 27 2 decreased platelet aggregation 3.08165161143596e-05 0.000272797451368219 0.592048528992668 0.851851851851852 27.2 27 2 abnormal heart valve morphology 0.00340826948090532 0.0166891148302204 0.592048528992668 0.851851851851852 27.2 27 2 increased brain weight 0.00340826948090532 0.0166891148302204 0.592048528992668 0.851851851851852 27.2 27 2 abnormal palate morphology 0.00340826948090532 0.0166891148302204 0.592048528992668 0.851851851851852 27.2 27 2 decreased circulating HDL cholesterol level 1.24999592818388e-10 3.27301565406043e-09 0.591847425552114 0.8515625 27.2 27 2 abnormal lens morphology 1.24999592818388e-10 3.27301565406043e-09 0.591847425552114 0.8515625 27.2 27 2 weight loss 5.22420727539093e-14 2.221404375647e-12 0.5917543433882 0.851428571428571 27.2 27 2 abnormal bone mineralization 4.23671163718346e-10 1.01334809591287e-08 0.591623053944883 0.851239669421488 27.2 27 2 increased total body fat amount 5.35377019127905e-11 1.47411335455951e-09 0.591280133757116 0.850746268656716 27.2 27 2 enlarged spleen 5.2090552573355e-22 5.39896873025919e-20 0.59124411523045 0.850694444444444 27.2 27 2 abnormal retinal pigmentation 1.33329142058664e-07 2.00396520163702e-06 0.591160900013669 0.850574712643678 27.2 27 2 epidermal hyperplasia 1.28777900026204e-05 0.000123681477341769 0.590761466973119 0.85 27.2 27 2 abnormal female reproductive system morphology 0.000381780288686164 0.00257365438511337 0.590761466973119 0.85 27.2 27 2 abnormal skin pigmentation 0.000381780288686164 0.00257365438511337 0.590761466973119 0.85 27.2 27 2 small gonad 0.0127500185028339 0.0501433534004734 0.590761466973119 0.85 27.2 27 2 increased urine glucose level 0.0127500185028339 0.0501433534004734 0.590761466973119 0.85 27.2 27 2 abnormal hair texture 0.0127500185028339 0.0501433534004734 0.590761466973119 0.85 27.2 27 2 abnormal optic stalk morphology 0.0127500185028339 0.0501433534004734 0.590761466973119 0.85 27.2 27 2 abnormal response to tactile stimuli 0.0127500185028339 0.0501433534004734 0.590761466973119 0.85 27.2 27 2 abnormal induced retinal neovascularization 0.0127500185028339 0.0501433534004734 0.590761466973119 0.85 27.2 27 2 abnormal neuron proliferation 0.0127500185028339 0.0501433534004734 0.590761466973119 0.85 27.2 27 2 reduced female fertility 8.62137719274179e-18 5.95713215748478e-16 0.590162317412294 0.849137931034483 27.2 27 2 azoospermia 1.24732265886665e-12 4.13695348524104e-11 0.59010579386882 0.849056603773585 27.2 27 2 increased mean corpuscular hemoglobin 2.40521764145839e-08 4.20864144817728e-07 0.589708416229851 0.848484848484849 27.2 27 2 abnormal epidermis stratum basale morphology 0.00136658111299498 0.00774344081679959 0.589708416229851 0.848484848484849 27.2 27 2 head tossing 0.00136658111299498 0.00774344081679959 0.589708416229851 0.848484848484849 27.2 27 2 cardiovascular system phenotype 0.00136658111299498 0.00774344081679959 0.589708416229851 0.848484848484849 27.2 27 2 decreased sensitivity to xenobiotic induced morbidity/mortality 0.00136658111299498 0.00774344081679959 0.589708416229851 0.848484848484849 27.2 27 2 thrombocytopenia 1.42059275236346e-11 4.23200535509474e-10 0.589563167851469 0.848275862068966 27.2 27 2 increased body weight 4.19479413578728e-17 2.60863760319272e-15 0.589520371454268 0.848214285714286 27.2 27 2 decreased food intake 6.61293320124047e-07 8.84390932155144e-06 0.589441821104973 0.848101265822785 27.2 27 2 impaired glucose tolerance 1.42516707147419e-18 1.16232888206297e-16 0.588519487971323 0.846774193548387 27.2 27 2 cachexia 1.47701053716792e-08 2.7624539181994e-07 0.588088338163286 0.846153846153846 27.2 27 2 increased circulating alanine transaminase level 9.56056310590717e-07 1.24187471153755e-05 0.588088338163286 0.846153846153846 27.2 27 2 decreased B-1 B cell number 0.000554946548505048 0.00357624233006815 0.588088338163286 0.846153846153846 27.2 27 2 decreased trabecular bone volume 0.000554946548505048 0.00357624233006815 0.588088338163286 0.846153846153846 27.2 27 2 abnormal ureter morphology 0.0049789942676939 0.0229980985286793 0.588088338163286 0.846153846153846 27.2 27 2 thick skin 0.0049789942676939 0.0229980985286793 0.588088338163286 0.846153846153846 27.2 27 2 increased susceptibility to otitis media 0.0049789942676939 0.0229980985286793 0.588088338163286 0.846153846153846 27.2 27 2 pulmonary edema 0.0049789942676939 0.0229980985286793 0.588088338163286 0.846153846153846 27.2 27 2 absent trabeculae carneae 0.0500157262959046 0.140899342198259 0.588088338163286 0.846153846153846 27.2 27 2 abnormal renal/urinary system morphology 0.0500157262959046 0.140899342198259 0.588088338163286 0.846153846153846 27.2 27 2 increased foot pad pigmentation 0.0500157262959046 0.140899342198259 0.588088338163286 0.846153846153846 27.2 27 2 small trigeminal ganglion 0.0500157262959046 0.140899342198259 0.588088338163286 0.846153846153846 27.2 27 2 pup cannibalization 0.0500157262959046 0.140899342198259 0.588088338163286 0.846153846153846 27.2 27 2 increased pituitary adenoma incidence 0.0500157262959046 0.140899342198259 0.588088338163286 0.846153846153846 27.2 27 2 abnormal pulmonary alveolus epithelial cell morphology 0.0500157262959046 0.140899342198259 0.588088338163286 0.846153846153846 27.2 27 2 abnormal lung interstitium morphology 0.0500157262959046 0.140899342198259 0.588088338163286 0.846153846153846 27.2 27 2 abnormal bile duct development 0.0500157262959046 0.140899342198259 0.588088338163286 0.846153846153846 27.2 27 2 abnormal coping response 0.0500157262959046 0.140899342198259 0.588088338163286 0.846153846153846 27.2 27 2 abnormal soleus morphology 0.0500157262959046 0.140899342198259 0.588088338163286 0.846153846153846 27.2 27 2 abnormal telomere length 0.0500157262959046 0.140899342198259 0.588088338163286 0.846153846153846 27.2 27 2 absent lateral semicircular canal 0.0500157262959046 0.140899342198259 0.588088338163286 0.846153846153846 27.2 27 2 abnormal GABAergic neuron morphology 0.0500157262959046 0.140899342198259 0.588088338163286 0.846153846153846 27.2 27 2 decreased endocochlear potential 0.0500157262959046 0.140899342198259 0.588088338163286 0.846153846153846 27.2 27 2 abnormal exocrine pancreas morphology 0.0500157262959046 0.140899342198259 0.588088338163286 0.846153846153846 27.2 27 2 hyperalgesia 0.0500157262959046 0.140899342198259 0.588088338163286 0.846153846153846 27.2 27 2 abnormal glucose homeostasis 6.07856404891099e-14 2.52007134527768e-12 0.588088338163286 0.846153846153846 27.2 27 2 decreased circulating glucose level 1.43678094783253e-20 1.27642593133336e-18 0.58789671602638 0.845878136200717 27.2 27 2 decreased bone mineral density 1.12568032584791e-19 9.82501687911115e-18 0.587887351034727 0.845864661654135 27.2 27 2 abnormal kidney morphology 2.04473972307669e-13 7.94732822055198e-12 0.587782837727876 0.845714285714286 27.2 27 2 arrest of spermatogenesis 4.03575665220847e-07 5.59272683697414e-06 0.587451878922849 0.845238095238095 27.2 27 2 abnormal renal glomerulus morphology 9.04483148842559e-09 1.77857852390978e-07 0.586616891112001 0.844036697247706 27.2 27 2 retinal degeneration 7.22610656715423e-08 1.1522397490895e-06 0.58641763265714 0.84375 27.2 27 2 increased circulating follicle stimulating hormone level 0.00198591691474214 0.0105894283503131 0.58641763265714 0.84375 27.2 27 2 thick epidermis 4.72555895613855e-06 5.23576502381068e-05 0.585797084897714 0.842857142857143 27.2 27 2 dehydration 4.72555895613855e-06 5.23576502381068e-05 0.585797084897714 0.842857142857143 27.2 27 2 abnormal circulating amino acid level 3.89602483624374e-05 0.000339452251494091 0.585274518363461 0.842105263157895 27.2 27 2 abnormal reproductive system physiology 0.000803420659257006 0.00487441192658976 0.585274518363461 0.842105263157895 27.2 27 2 abnormal triglyceride level 0.0186448909687623 0.0662559518354233 0.585274518363461 0.842105263157895 27.2 27 2 small superior vagus ganglion 0.0186448909687623 0.0662559518354233 0.585274518363461 0.842105263157895 27.2 27 2 decreased tumor incidence 0.0186448909687623 0.0662559518354233 0.585274518363461 0.842105263157895 27.2 27 2 decreased germ cell number 0.0186448909687623 0.0662559518354233 0.585274518363461 0.842105263157895 27.2 27 2 abnormal neural crest cell migration 0.0186448909687623 0.0662559518354233 0.585274518363461 0.842105263157895 27.2 27 2 abnormal optic vesicle formation 0.0186448909687623 0.0662559518354233 0.585274518363461 0.842105263157895 27.2 27 2 abnormal photoreceptor inner segment morphology 0.0186448909687623 0.0662559518354233 0.585274518363461 0.842105263157895 27.2 27 2 absent amnion 0.0186448909687623 0.0662559518354233 0.585274518363461 0.842105263157895 27.2 27 2 decreased eye pigmentation 0.0186448909687623 0.0662559518354233 0.585274518363461 0.842105263157895 27.2 27 2 Leydig cell hypoplasia 0.0186448909687623 0.0662559518354233 0.585274518363461 0.842105263157895 27.2 27 2 abnormal behavioral response to xenobiotic 0.0186448909687623 0.0662559518354233 0.585274518363461 0.842105263157895 27.2 27 2 increased liver cholesterol level 0.0186448909687623 0.0662559518354233 0.585274518363461 0.842105263157895 27.2 27 2 embryonic lethality between implantation and somite formation, incomplete penetrance 0.0186448909687623 0.0662559518354233 0.585274518363461 0.842105263157895 27.2 27 2 improved glucose tolerance 2.03890552546674e-14 9.30601375155691e-13 0.585087887458371 0.841836734693878 27.2 27 2 short femur 3.52753356517417e-07 4.94351534837788e-06 0.584443162513513 0.840909090909091 27.2 27 2 increased bone mineral density 7.9266799700942e-09 1.57740931404875e-07 0.584303377016619 0.84070796460177 27.2 27 2 enlarged liver 6.31172894187851e-08 1.01293069309179e-06 0.583811332067553 0.84 27.2 27 2 abnormal liver physiology 6.31172894187851e-08 1.01293069309179e-06 0.583811332067553 0.84 27.2 27 2 abnormal inner ear vestibule morphology 0.00723243188258279 0.0308059491574053 0.583811332067553 0.84 27.2 27 2 abnormal primitive streak morphology 0.00723243188258279 0.0308059491574053 0.583811332067553 0.84 27.2 27 2 abnormal egg cylinder morphology 0.00723243188258279 0.0308059491574053 0.583811332067553 0.84 27.2 27 2 abnormal preimplantation embryo development 0.00723243188258279 0.0308059491574053 0.583811332067553 0.84 27.2 27 2 decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 0.00723243188258279 0.0308059491574053 0.583811332067553 0.84 27.2 27 2 abnormal eye development 5.60235499499196e-05 0.000470806015204138 0.583314893860012 0.839285714285714 27.2 27 2 absent mature ovarian follicles 0.00287198649837667 0.0144910069263935 0.582914540466834 0.838709677419355 27.2 27 2 increased lung adenoma incidence 0.00287198649837667 0.0144910069263935 0.582914540466834 0.838709677419355 27.2 27 2 abnormal lipid homeostasis 8.72361389055521e-10 1.99999903712038e-08 0.58274208054362 0.838461538461538 27.2 27 2 deafness 9.03497754997823e-08 1.40028078850909e-06 0.582688077941401 0.838383838383838 27.2 27 2 decreased T cell proliferation 6.74555002132672e-11 1.84390721736816e-09 0.582308600196079 0.837837837837838 27.2 27 2 increased granulocyte number 4.08502634492054e-06 4.60839139818134e-05 0.582308600196079 0.837837837837838 27.2 27 2 decreased circulating chloride level 0.00115823988578654 0.00661566410078993 0.582308600196079 0.837837837837838 27.2 27 2 increased insulin secretion 0.00115823988578654 0.00661566410078993 0.582308600196079 0.837837837837838 27.2 27 2 abnormal homeostasis 0.00047225910830942 0.00310595134562773 0.581871759535767 0.837209302325581 27.2 27 2 organ of Corti degeneration 0.000194139237990797 0.00142876140385239 0.581541900261654 0.836734693877551 27.2 27 2 increased circulating LDL cholesterol level 0.000194139237990797 0.00142876140385239 0.581541900261654 0.836734693877551 27.2 27 2 increased sarcoma incidence 0.000194139237990797 0.00142876140385239 0.581541900261654 0.836734693877551 27.2 27 2 decreased circulating creatinine level 0.000194139237990797 0.00142876140385239 0.581541900261654 0.836734693877551 27.2 27 2 increased sensitivity to xenobiotic induced morbidity/mortality 2.31739853036214e-08 4.07387197475324e-07 0.581284010283711 0.836363636363636 27.2 27 2 decreased bone marrow cell number 5.83887566141915e-06 6.27395386945146e-05 0.5807646975884 0.835616438356164 27.2 27 2 abnormal B cell differentiation 4.35640038120035e-07 6.0036265641196e-06 0.580450827278048 0.835164835164835 27.2 27 2 increased leukocyte cell number 1.95220896925031e-10 4.90517152627286e-09 0.579976774878275 0.83448275862069 27.2 27 2 abnormal enzyme/coenzyme activity 3.54836481092919e-11 1.01454683530878e-09 0.57991571505042 0.834394904458599 27.2 27 2 abnormal blood homeostasis 1.99317612230173e-08 3.55414021808284e-07 0.579177908797175 0.833333333333333 27.2 27 2 increased cell proliferation 0.00011476990534023 0.000906317903281971 0.579177908797175 0.833333333333333 27.2 27 2 abnormal kidney physiology 0.000277737804316513 0.00194886541110671 0.579177908797175 0.833333333333333 27.2 27 2 abnormal osteoclast morphology 0.000277737804316513 0.00194886541110671 0.579177908797175 0.833333333333333 27.2 27 2 impaired wound healing 0.00166234118440866 0.00915852424411194 0.579177908797175 0.833333333333333 27.2 27 2 head tilt 0.00166234118440866 0.00915852424411194 0.579177908797175 0.833333333333333 27.2 27 2 abnormal pain threshold 0.00413206739182173 0.0197904479936307 0.579177908797175 0.833333333333333 27.2 27 2 abnormal cellular respiration 0.00413206739182173 0.0197904479936307 0.579177908797175 0.833333333333333 27.2 27 2 decreased metastatic potential 0.0104417445080694 0.0418167194128172 0.579177908797175 0.833333333333333 27.2 27 2 hemolytic anemia 0.0104417445080694 0.0418167194128172 0.579177908797175 0.833333333333333 27.2 27 2 abnormal vasodilation 0.0104417445080694 0.0418167194128172 0.579177908797175 0.833333333333333 27.2 27 2 small lymph nodes 0.0104417445080694 0.0418167194128172 0.579177908797175 0.833333333333333 27.2 27 2 abnormal osteoblast morphology 0.0104417445080694 0.0418167194128172 0.579177908797175 0.833333333333333 27.2 27 2 abnormal radius morphology 0.0270607075893746 0.0871372299398954 0.579177908797175 0.833333333333333 27.2 27 2 absent spleen 0.0270607075893746 0.0871372299398954 0.579177908797175 0.833333333333333 27.2 27 2 abnormal retinal rod cell morphology 0.0270607075893746 0.0871372299398954 0.579177908797175 0.833333333333333 27.2 27 2 absent allantois 0.0270607075893746 0.0871372299398954 0.579177908797175 0.833333333333333 27.2 27 2 abnormal redox activity 0.0270607075893746 0.0871372299398954 0.579177908797175 0.833333333333333 27.2 27 2 decreased cellular sensitivity to gamma-irradiation 0.0270607075893746 0.0871372299398954 0.579177908797175 0.833333333333333 27.2 27 2 decreased heart rate variability 0.0270607075893746 0.0871372299398954 0.579177908797175 0.833333333333333 27.2 27 2 long tibia 0.0270607075893746 0.0871372299398954 0.579177908797175 0.833333333333333 27.2 27 2 abnormal anterior eye segment morphology 0.0270607075893746 0.0871372299398954 0.579177908797175 0.833333333333333 27.2 27 2 jerky movement 0.0270607075893746 0.0871372299398954 0.579177908797175 0.833333333333333 27.2 27 2 abnormal glycogen homeostasis 0.0270607075893746 0.0871372299398954 0.579177908797175 0.833333333333333 27.2 27 2 decreased pulmonary respiratory rate 0.0270607075893746 0.0871372299398954 0.579177908797175 0.833333333333333 27.2 27 2 decreased fluid intake 0.0270607075893746 0.0871372299398954 0.579177908797175 0.833333333333333 27.2 27 2 impaired leukocyte tethering or rolling 0.0270607075893746 0.0871372299398954 0.579177908797175 0.833333333333333 27.2 27 2 abnormal adipose tissue distribution 0.0732538438299129 0.182492675540219 0.579177908797175 0.833333333333333 27.2 27 2 decreased digestive secretion 0.0732538438299129 0.182492675540219 0.579177908797175 0.833333333333333 27.2 27 2 amyloidosis 0.0732538438299129 0.182492675540219 0.579177908797175 0.833333333333333 27.2 27 2 mesocardia 0.0732538438299129 0.182492675540219 0.579177908797175 0.833333333333333 27.2 27 2 abnormal glossopharyngeal nerve morphology 0.0732538438299129 0.182492675540219 0.579177908797175 0.833333333333333 27.2 27 2 ear inflammation 0.0732538438299129 0.182492675540219 0.579177908797175 0.833333333333333 27.2 27 2 myocarditis 0.0732538438299129 0.182492675540219 0.579177908797175 0.833333333333333 27.2 27 2 interstitial pneumonia 0.0732538438299129 0.182492675540219 0.579177908797175 0.833333333333333 27.2 27 2 small thyroid gland 0.0732538438299129 0.182492675540219 0.579177908797175 0.833333333333333 27.2 27 2 small intestinal inflammation 0.0732538438299129 0.182492675540219 0.579177908797175 0.833333333333333 27.2 27 2 absent tail 0.0732538438299129 0.182492675540219 0.579177908797175 0.833333333333333 27.2 27 2 decreased circulating ketone body level 0.0732538438299129 0.182492675540219 0.579177908797175 0.833333333333333 27.2 27 2 impaired sperm capacitation 0.0732538438299129 0.182492675540219 0.579177908797175 0.833333333333333 27.2 27 2 delayed somite formation 0.0732538438299129 0.182492675540219 0.579177908797175 0.833333333333333 27.2 27 2 abnormal defecation 0.0732538438299129 0.182492675540219 0.579177908797175 0.833333333333333 27.2 27 2 bowed ulna 0.0732538438299129 0.182492675540219 0.579177908797175 0.833333333333333 27.2 27 2 stria vascularis degeneration 0.0732538438299129 0.182492675540219 0.579177908797175 0.833333333333333 27.2 27 2 decreased cochlear nerve compound action potential 0.0732538438299129 0.182492675540219 0.579177908797175 0.833333333333333 27.2 27 2 hemoperitoneum 0.0732538438299129 0.182492675540219 0.579177908797175 0.833333333333333 27.2 27 2 decreased keratinocyte proliferation 0.0732538438299129 0.182492675540219 0.579177908797175 0.833333333333333 27.2 27 2 hydrometra 0.0732538438299129 0.182492675540219 0.579177908797175 0.833333333333333 27.2 27 2 abnormal behavioral response to addictive substance 0.0732538438299129 0.182492675540219 0.579177908797175 0.833333333333333 27.2 27 2 impaired behavioral response to cocaine 0.0732538438299129 0.182492675540219 0.579177908797175 0.833333333333333 27.2 27 2 increased skeletal muscle glycogen level 0.0732538438299129 0.182492675540219 0.579177908797175 0.833333333333333 27.2 27 2 echinocytosis 0.217977882953361 0.378249029540625 0.579177908797175 0.833333333333333 27.2 27 2 absent organized vascular network 0.217977882953361 0.378249029540625 0.579177908797175 0.833333333333333 27.2 27 2 ectopic digits 0.217977882953361 0.378249029540625 0.579177908797175 0.833333333333333 27.2 27 2 small prostate gland anterior lobe 0.217977882953361 0.378249029540625 0.579177908797175 0.833333333333333 27.2 27 2 abnormal lens induction 0.217977882953361 0.378249029540625 0.579177908797175 0.833333333333333 27.2 27 2 abnormal gustatory system physiology 0.217977882953361 0.378249029540625 0.579177908797175 0.833333333333333 27.2 27 2 abnormal parental behavior 0.217977882953361 0.378249029540625 0.579177908797175 0.833333333333333 27.2 27 2 abnormal gland physiology 0.217977882953361 0.378249029540625 0.579177908797175 0.833333333333333 27.2 27 2 abnormal internal nares morphology 0.217977882953361 0.378249029540625 0.579177908797175 0.833333333333333 27.2 27 2 abnormal pulmonary alveolar duct morphology 0.217977882953361 0.378249029540625 0.579177908797175 0.833333333333333 27.2 27 2 abnormal lymph node cortex morphology 0.217977882953361 0.378249029540625 0.579177908797175 0.833333333333333 27.2 27 2 abnormal cervical lymph node morphology 0.217977882953361 0.378249029540625 0.579177908797175 0.833333333333333 27.2 27 2 aganglionic megacolon 0.217977882953361 0.378249029540625 0.579177908797175 0.833333333333333 27.2 27 2 retina hypoplasia 0.217977882953361 0.378249029540625 0.579177908797175 0.833333333333333 27.2 27 2 abnormal sebaceous lipid secretion 0.217977882953361 0.378249029540625 0.579177908797175 0.833333333333333 27.2 27 2 ectopic thymus 0.217977882953361 0.378249029540625 0.579177908797175 0.833333333333333 27.2 27 2 acidemia 0.217977882953361 0.378249029540625 0.579177908797175 0.833333333333333 27.2 27 2 extremity edema 0.217977882953361 0.378249029540625 0.579177908797175 0.833333333333333 27.2 27 2 abnormal intestinal peristalsis 0.217977882953361 0.378249029540625 0.579177908797175 0.833333333333333 27.2 27 2 pancreas fibrosis 0.217977882953361 0.378249029540625 0.579177908797175 0.833333333333333 27.2 27 2 early sexual maturation 0.217977882953361 0.378249029540625 0.579177908797175 0.833333333333333 27.2 27 2 short perineum 0.217977882953361 0.378249029540625 0.579177908797175 0.833333333333333 27.2 27 2 ureter obstruction 0.217977882953361 0.378249029540625 0.579177908797175 0.833333333333333 27.2 27 2 decreased heart right ventricle size 0.217977882953361 0.378249029540625 0.579177908797175 0.833333333333333 27.2 27 2 abnormal heart left atrium morphology 0.217977882953361 0.378249029540625 0.579177908797175 0.833333333333333 27.2 27 2 abnormal cholesterol level 0.217977882953361 0.378249029540625 0.579177908797175 0.833333333333333 27.2 27 2 abnormal motor nerve collateral sprouting 0.217977882953361 0.378249029540625 0.579177908797175 0.833333333333333 27.2 27 2 absent incus 0.217977882953361 0.378249029540625 0.579177908797175 0.833333333333333 27.2 27 2 bowed humerus 0.217977882953361 0.378249029540625 0.579177908797175 0.833333333333333 27.2 27 2 decreased cochlear microphonics 0.217977882953361 0.378249029540625 0.579177908797175 0.833333333333333 27.2 27 2 absent cochlear nerve compound action potential 0.217977882953361 0.378249029540625 0.579177908797175 0.833333333333333 27.2 27 2 variegated coat color 0.217977882953361 0.378249029540625 0.579177908797175 0.833333333333333 27.2 27 2 decreased susceptibility to fungal infection 0.217977882953361 0.378249029540625 0.579177908797175 0.833333333333333 27.2 27 2 abnormal heart size 0.217977882953361 0.378249029540625 0.579177908797175 0.833333333333333 27.2 27 2 abnormal adipose tissue amount 0.217977882953361 0.378249029540625 0.579177908797175 0.833333333333333 27.2 27 2 abnormal pulmonary respiratory rate 0.217977882953361 0.378249029540625 0.579177908797175 0.833333333333333 27.2 27 2 delayed chorioallantoic fusion 0.217977882953361 0.378249029540625 0.579177908797175 0.833333333333333 27.2 27 2 increased urine uric acid level 0.217977882953361 0.378249029540625 0.579177908797175 0.833333333333333 27.2 27 2 absent sperm mitochondrial sheath 0.217977882953361 0.378249029540625 0.579177908797175 0.833333333333333 27.2 27 2 absent tongue 0.217977882953361 0.378249029540625 0.579177908797175 0.833333333333333 27.2 27 2 abnormal olfactory bulb layer morphology 0.217977882953361 0.378249029540625 0.579177908797175 0.833333333333333 27.2 27 2 variable depigmentation 0.217977882953361 0.378249029540625 0.579177908797175 0.833333333333333 27.2 27 2 abnormal renal water reabsorbtion 0.217977882953361 0.378249029540625 0.579177908797175 0.833333333333333 27.2 27 2 abnormal bone mineral density 0.217977882953361 0.378249029540625 0.579177908797175 0.833333333333333 27.2 27 2 common truncal valve 0.217977882953361 0.378249029540625 0.579177908797175 0.833333333333333 27.2 27 2 absent third pharyngeal arch 0.217977882953361 0.378249029540625 0.579177908797175 0.833333333333333 27.2 27 2 abnormal pre-Botzinger complex physiology 0.217977882953361 0.378249029540625 0.579177908797175 0.833333333333333 27.2 27 2 absent alveolar lamellar bodies 0.217977882953361 0.378249029540625 0.579177908797175 0.833333333333333 27.2 27 2 abnormal respiratory epithelium morphology 0.217977882953361 0.378249029540625 0.579177908797175 0.833333333333333 27.2 27 2 ectopic ureteric bud 0.217977882953361 0.378249029540625 0.579177908797175 0.833333333333333 27.2 27 2 abnormal ureteric bud elongation 0.217977882953361 0.378249029540625 0.579177908797175 0.833333333333333 27.2 27 2 podocyte hypertrophy 0.217977882953361 0.378249029540625 0.579177908797175 0.833333333333333 27.2 27 2 abnormal circulating osteocalcin level 0.217977882953361 0.378249029540625 0.579177908797175 0.833333333333333 27.2 27 2 abnormal endocrine pancreas development 0.217977882953361 0.378249029540625 0.579177908797175 0.833333333333333 27.2 27 2 increased total retina thickness 0.217977882953361 0.378249029540625 0.579177908797175 0.833333333333333 27.2 27 2 absent midbrain 0.217977882953361 0.378249029540625 0.579177908797175 0.833333333333333 27.2 27 2 abnormal Rathke's pouch development 0.217977882953361 0.378249029540625 0.579177908797175 0.833333333333333 27.2 27 2 thymus cortex atrophy 0.217977882953361 0.378249029540625 0.579177908797175 0.833333333333333 27.2 27 2 increased CD11b-high dendritic cell number 0.217977882953361 0.378249029540625 0.579177908797175 0.833333333333333 27.2 27 2 absent thymus corticomedullary boundary 0.217977882953361 0.378249029540625 0.579177908797175 0.833333333333333 27.2 27 2 ciliary body hypoplasia 0.217977882953361 0.378249029540625 0.579177908797175 0.833333333333333 27.2 27 2 absent embryonic telencephalon 0.217977882953361 0.378249029540625 0.579177908797175 0.833333333333333 27.2 27 2 increased male germ cell apoptosis 0.217977882953361 0.378249029540625 0.579177908797175 0.833333333333333 27.2 27 2 abnormal platelet alpha-granule morphology 0.217977882953361 0.378249029540625 0.579177908797175 0.833333333333333 27.2 27 2 abnormal embryo morphology 0.217977882953361 0.378249029540625 0.579177908797175 0.833333333333333 27.2 27 2 increased body fat mass 0.217977882953361 0.378249029540625 0.579177908797175 0.833333333333333 27.2 27 2 ectopic bone 0.217977882953361 0.378249029540625 0.579177908797175 0.833333333333333 27.2 27 2 increased spleen weight 2.83033768698223e-08 4.83880755764145e-07 0.578152815153286 0.831858407079646 27.2 27 2 increased circulating insulin level 4.32788120857223e-11 1.23035480072268e-09 0.577729964025182 0.83125 27.2 27 2 polyuria 4.96890057919932e-06 5.43302865527838e-05 0.577673550592507 0.831168831168831 27.2 27 2 abnormal CD4-positive, alpha-beta T cell physiology 1.18398341167515e-05 0.000116871378434204 0.577546421730141 0.830985915492958 27.2 27 2 abnormal pancreatic islet morphology 0.0001634694573194 0.00122294819573536 0.576992331782846 0.830188679245283 27.2 27 2 decreased double-positive T cell number 2.23308384012889e-07 3.23492454313529e-06 0.576861197161987 0.83 27.2 27 2 increased circulating cholesterol level 6.74454311551547e-12 2.05853386501162e-10 0.576545281939006 0.829545454545455 27.2 27 2 hyperglycemia 1.24980787335025e-06 1.57015004290846e-05 0.576545281939006 0.829545454545455 27.2 27 2 increased T cell number 1.24980787335025e-06 1.57015004290846e-05 0.576545281939006 0.829545454545455 27.2 27 2 liver fibrosis 0.000965289578775235 0.00581394147022614 0.576352650705482 0.829268292682927 27.2 27 2 abnormal cholesterol homeostasis 0.000965289578775235 0.00581394147022614 0.576352650705482 0.829268292682927 27.2 27 2 decreased neutrophil cell number 2.41098052810156e-08 4.20864144817728e-07 0.576207765675139 0.829059829059829 27.2 27 2 male infertility 3.1603589209183e-31 6.04722524291098e-29 0.576184146246733 0.829025844930418 27.2 27 2 spleen hypoplasia 1.33865221963323e-07 2.0059622869504e-06 0.575868320746906 0.828571428571429 27.2 27 2 ovary cysts 0.00237466646202131 0.0125280653749269 0.575868320746906 0.828571428571429 27.2 27 2 abnormal embryonic erythropoiesis 0.00591250685332023 0.0261464191957939 0.575183578391678 0.827586206896552 27.2 27 2 female infertility 6.7109781104554e-17 4.02254410837537e-15 0.574823187678399 0.827067669172932 27.2 27 2 absent corpus luteum 0.0002320387990005 0.00166339052597621 0.57472269411412 0.826923076923077 27.2 27 2 abnormal epidermal layer morphology 2.37583702134748e-05 0.000217675675528614 0.574141579155461 0.826086956521739 27.2 27 2 abnormal coat appearance 2.37583702134748e-05 0.000217675675528614 0.574141579155461 0.826086956521739 27.2 27 2 abnormal lymphocyte physiology 0.000562144216551544 0.0036179398154514 0.574141579155461 0.826086956521739 27.2 27 2 abnormal carpal bone morphology 0.0149760321634831 0.0553591703450083 0.574141579155461 0.826086956521739 27.2 27 2 failure of embryo implantation 0.0149760321634831 0.0553591703450083 0.574141579155461 0.826086956521739 27.2 27 2 abnormal cardiovascular development 0.0149760321634831 0.0553591703450083 0.574141579155461 0.826086956521739 27.2 27 2 abnormal crista ampullaris morphology 0.0149760321634831 0.0553591703450083 0.574141579155461 0.826086956521739 27.2 27 2 decreased litter size 1.47209555919025e-17 9.76490054262865e-16 0.57381896729229 0.825622775800712 27.2 27 2 head bobbing 0.0013713017733655 0.00775252991192429 0.573386129709204 0.825 27.2 27 2 abnormal pancreatic beta cell morphology 0.0013713017733655 0.00775252991192429 0.573386129709204 0.825 27.2 27 2 increased macrophage cell number 0.000136221067411087 0.00105890595370337 0.573081299230889 0.824561403508772 27.2 27 2 small seminiferous tubules 1.40684763003746e-05 0.00013485678149203 0.572916525999368 0.824324324324324 27.2 27 2 abnormal gluconeogenesis 0.000328203209830622 0.00224287221003756 0.57236405104662 0.823529411764706 27.2 27 2 abnormal endoderm development 0.00337545236737999 0.0165773697213381 0.57236405104662 0.823529411764706 27.2 27 2 increased width of hypertrophic chondrocyte zone 0.00337545236737999 0.0165773697213381 0.57236405104662 0.823529411764706 27.2 27 2 decreased regulatory T cell number 0.00337545236737999 0.0165773697213381 0.57236405104662 0.823529411764706 27.2 27 2 hydroureter 0.0389501525201445 0.120797179207342 0.57236405104662 0.823529411764706 27.2 27 2 abnormal urinary bladder morphology 0.0389501525201445 0.120797179207342 0.57236405104662 0.823529411764706 27.2 27 2 abnormal vagus nerve morphology 0.0389501525201445 0.120797179207342 0.57236405104662 0.823529411764706 27.2 27 2 increased incidence of corneal inflammation 0.0389501525201445 0.120797179207342 0.57236405104662 0.823529411764706 27.2 27 2 aminoaciduria 0.0389501525201445 0.120797179207342 0.57236405104662 0.823529411764706 27.2 27 2 abnormal testis development 0.0389501525201445 0.120797179207342 0.57236405104662 0.823529411764706 27.2 27 2 increased circulating magnesium level 0.0389501525201445 0.120797179207342 0.57236405104662 0.823529411764706 27.2 27 2 increased hepatoma incidence 0.0389501525201445 0.120797179207342 0.57236405104662 0.823529411764706 27.2 27 2 abnormal survival 0.0389501525201445 0.120797179207342 0.57236405104662 0.823529411764706 27.2 27 2 decreased body fat mass 0.0389501525201445 0.120797179207342 0.57236405104662 0.823529411764706 27.2 27 2 increased T cell proliferation 2.23681214640912e-07 3.23492454313529e-06 0.571599880083941 0.822429906542056 27.2 27 2 decreased insulin secretion 2.08909831955272e-06 2.49238948196038e-05 0.57145553667988 0.822222222222222 27.2 27 2 abnormal ovarian follicle morphology 0.000795060227008094 0.00482957830203329 0.57145553667988 0.822222222222222 27.2 27 2 abnormal metabolism 0.000795060227008094 0.00482957830203329 0.57145553667988 0.822222222222222 27.2 27 2 abnormal circulating cholesterol level 0.00841078951696687 0.0354571316805298 0.570903938671501 0.821428571428571 27.2 27 2 abnormal ovulation 0.00841078951696687 0.0354571316805298 0.570903938671501 0.821428571428571 27.2 27 2 failure of blastocyst to hatch from the zona pellucida 0.00841078951696687 0.0354571316805298 0.570903938671501 0.821428571428571 27.2 27 2 increased circulating chloride level 0.000462511818312902 0.00305577197358126 0.569911062256421 0.82 27.2 27 2 testicular atrophy 0.000462511818312902 0.00305577197358126 0.569911062256421 0.82 27.2 27 2 abnormal circulating protein level 0.000462511818312902 0.00305577197358126 0.569911062256421 0.82 27.2 27 2 decreased T cell number 3.38564031149029e-10 8.2163709998362e-09 0.569824725176848 0.819875776397516 27.2 27 2 increased osteoclast cell number 0.000112597708358755 0.000890578058958354 0.569683188980828 0.819672131147541 27.2 27 2 increased double-negative T cell number 0.000112597708358755 0.000890578058958354 0.569683188980828 0.819672131147541 27.2 27 2 cochlear outer hair cell degeneration 2.77913074072358e-05 0.000248225770827645 0.569524943650556 0.819444444444444 27.2 27 2 abnormal lipid level 6.92678549483178e-06 7.34770956008275e-05 0.569408642865657 0.819277108433735 27.2 27 2 increased circulating calcium level 0.000269823412465404 0.00189868667187466 0.568647401364499 0.818181818181818 27.2 27 2 dextrocardia 0.00477292802260433 0.0223170271733614 0.568647401364499 0.818181818181818 27.2 27 2 abnormal skeleton physiology 0.00477292802260433 0.0223170271733614 0.568647401364499 0.818181818181818 27.2 27 2 abnormal T cell subpopulation ratio 0.00477292802260433 0.0223170271733614 0.568647401364499 0.818181818181818 27.2 27 2 increased osteoblast cell number 0.00477292802260433 0.0223170271733614 0.568647401364499 0.818181818181818 27.2 27 2 teratozoospermia 4.10155855448684e-06 4.61657325985792e-05 0.568647401364499 0.818181818181818 27.2 27 2 decreased macrophage cell number 0.00111982366253777 0.00651593300716419 0.568647401364499 0.818181818181818 27.2 27 2 cochlear hair cell degeneration 0.00111982366253777 0.00651593300716419 0.568647401364499 0.818181818181818 27.2 27 2 abnormal germ layer development 0.0213264779707258 0.0753545652729836 0.568647401364499 0.818181818181818 27.2 27 2 intracerebral hemorrhage 0.0213264779707258 0.0753545652729836 0.568647401364499 0.818181818181818 27.2 27 2 abnormal cochlear sensory epithelium morphology 0.0213264779707258 0.0753545652729836 0.568647401364499 0.818181818181818 27.2 27 2 parakeratosis 0.0213264779707258 0.0753545652729836 0.568647401364499 0.818181818181818 27.2 27 2 abnormal thrombopoiesis 0.106081097092151 0.247887955863528 0.568647401364499 0.818181818181818 27.2 27 2 decreased atrioventricular cushion size 0.106081097092151 0.247887955863528 0.568647401364499 0.818181818181818 27.2 27 2 abnormal awl hair morphology 0.106081097092151 0.247887955863528 0.568647401364499 0.818181818181818 27.2 27 2 enlarged cranium 0.106081097092151 0.247887955863528 0.568647401364499 0.818181818181818 27.2 27 2 abnormal sebaceous gland morphology 0.106081097092151 0.247887955863528 0.568647401364499 0.818181818181818 27.2 27 2 abnormal hemoglobin 0.106081097092151 0.247887955863528 0.568647401364499 0.818181818181818 27.2 27 2 abnormal larynx morphology 0.106081097092151 0.247887955863528 0.568647401364499 0.818181818181818 27.2 27 2 abnormal bronchiole morphology 0.106081097092151 0.247887955863528 0.568647401364499 0.818181818181818 27.2 27 2 decreased post-tetanic potentiation 0.106081097092151 0.247887955863528 0.568647401364499 0.818181818181818 27.2 27 2 retinal detachment 0.106081097092151 0.247887955863528 0.568647401364499 0.818181818181818 27.2 27 2 loss of cortex neurons 0.106081097092151 0.247887955863528 0.568647401364499 0.818181818181818 27.2 27 2 rectal hemorrhage 0.106081097092151 0.247887955863528 0.568647401364499 0.818181818181818 27.2 27 2 abnormal nerve fiber response 0.106081097092151 0.247887955863528 0.568647401364499 0.818181818181818 27.2 27 2 pulmonary hypertension 0.106081097092151 0.247887955863528 0.568647401364499 0.818181818181818 27.2 27 2 abnormal lymph circulation 0.106081097092151 0.247887955863528 0.568647401364499 0.818181818181818 27.2 27 2 abnormal ureter development 0.106081097092151 0.247887955863528 0.568647401364499 0.818181818181818 27.2 27 2 abnormal hair medulla 0.106081097092151 0.247887955863528 0.568647401364499 0.818181818181818 27.2 27 2 increased motor neuron number 0.106081097092151 0.247887955863528 0.568647401364499 0.818181818181818 27.2 27 2 abnormal superovulation 0.106081097092151 0.247887955863528 0.568647401364499 0.818181818181818 27.2 27 2 enhanced behavioral response to addictive substance 0.106081097092151 0.247887955863528 0.568647401364499 0.818181818181818 27.2 27 2 abnormal aorta smooth muscle morphology 0.106081097092151 0.247887955863528 0.568647401364499 0.818181818181818 27.2 27 2 shortened PR interval 0.106081097092151 0.247887955863528 0.568647401364499 0.818181818181818 27.2 27 2 increased pancreatic beta cell proliferation 0.106081097092151 0.247887955863528 0.568647401364499 0.818181818181818 27.2 27 2 abnormal phrenic nerve innervation pattern to diaphragm 0.106081097092151 0.247887955863528 0.568647401364499 0.818181818181818 27.2 27 2 chylous ascites 0.106081097092151 0.247887955863528 0.568647401364499 0.818181818181818 27.2 27 2 hypolactation 0.106081097092151 0.247887955863528 0.568647401364499 0.818181818181818 27.2 27 2 abnormal eye physiology 0.000157794899766362 0.00118227353364104 0.567594350621232 0.816666666666667 27.2 27 2 increased bone marrow cell number 0.00272958217470302 0.0139564967308813 0.566984689664603 0.815789473684211 27.2 27 2 abnormal compact bone morphology 0.00272958217470302 0.0139564967308813 0.566984689664603 0.815789473684211 27.2 27 2 decreased threshold for auditory brainstem response 0.00272958217470302 0.0139564967308813 0.566984689664603 0.815789473684211 27.2 27 2 decreased tumor growth/size 0.000377747486027744 0.00255338823775547 0.566307288601683 0.814814814814815 27.2 27 2 abnormal type II pneumocyte morphology 0.0118901833295637 0.0470968647010982 0.566307288601683 0.814814814814815 27.2 27 2 decreased IgM level 2.00673103100315e-06 2.39987665366362e-05 0.566041914989404 0.814432989690722 27.2 27 2 abnormal male reproductive system morphology 0.00157041890919089 0.00879001781215478 0.565708655104218 0.813953488372093 27.2 27 2 abnormal blood circulation 0.00157041890919089 0.00879001781215478 0.565708655104218 0.813953488372093 27.2 27 2 decreased oxygen consumption 0.00157041890919089 0.00879001781215478 0.565708655104218 0.813953488372093 27.2 27 2 increased circulating triglyceride level 6.93551693791911e-09 1.3912982566995e-07 0.565597185418483 0.813793103448276 27.2 27 2 increased B cell proliferation 0.00022039909924008 0.00158223018574228 0.565434704181649 0.813559322033898 27.2 27 2 abnormal urine homeostasis 2.788660139357e-06 3.31111794589524e-05 0.564698461077246 0.8125 27.2 27 2 abnormal lymph node morphology 0.000907855458684458 0.00549462397439802 0.564698461077246 0.8125 27.2 27 2 absent mandible 0.0555490158997597 0.155256378708598 0.564698461077246 0.8125 27.2 27 2 decreased mast cell number 0.0555490158997597 0.155256378708598 0.564698461077246 0.8125 27.2 27 2 delayed hair appearance 0.0555490158997597 0.155256378708598 0.564698461077246 0.8125 27.2 27 2 reduced male mating frequency 0.0555490158997597 0.155256378708598 0.564698461077246 0.8125 27.2 27 2 abnormal meiosis 0.0555490158997597 0.155256378708598 0.564698461077246 0.8125 27.2 27 2 abnormal olfaction 0.0555490158997597 0.155256378708598 0.564698461077246 0.8125 27.2 27 2 paternal imprinting 0.0555490158997597 0.155256378708598 0.564698461077246 0.8125 27.2 27 2 abnormal molar crown morphology 0.0555490158997597 0.155256378708598 0.564698461077246 0.8125 27.2 27 2 increased thymus weight 0.0555490158997597 0.155256378708598 0.564698461077246 0.8125 27.2 27 2 decreased circulating growth hormone level 0.0555490158997597 0.155256378708598 0.564698461077246 0.8125 27.2 27 2 decreased circulating prolactin level 0.0555490158997597 0.155256378708598 0.564698461077246 0.8125 27.2 27 2 decreased circulating triiodothyronine level 0.0555490158997597 0.155256378708598 0.564698461077246 0.8125 27.2 27 2 decreased midbrain size 0.0555490158997597 0.155256378708598 0.564698461077246 0.8125 27.2 27 2 increased lymphocyte cell number 7.5553802239242e-05 0.000617208811396107 0.564068919872032 0.811594202898551 27.2 27 2 abnormal food intake 7.5553802239242e-05 0.000617208811396107 0.564068919872032 0.811594202898551 27.2 27 2 abnormal placenta development 0.000526886968229234 0.00340423722979278 0.563878869696873 0.811320754716981 27.2 27 2 abnormal branching of the mammary ductal tree 0.00382277532136063 0.0186453992389893 0.563524451802657 0.810810810810811 27.2 27 2 increased circulating phosphate level 0.00382277532136063 0.0186453992389893 0.563524451802657 0.810810810810811 27.2 27 2 increased trabecular bone volume 0.00382277532136063 0.0186453992389893 0.563524451802657 0.810810810810811 27.2 27 2 abnormal spermiogenesis 0.000306782630650396 0.0021139107859913 0.563200587175184 0.810344827586207 27.2 27 2 abnormal enzyme/coenzyme level 0.000306782630650396 0.0021139107859913 0.563200587175184 0.810344827586207 27.2 27 2 thrombocytosis 0.000306782630650396 0.0021139107859913 0.563200587175184 0.810344827586207 27.2 27 2 hydronephrosis 1.53661871544086e-05 0.00014616975352425 0.562629968545827 0.80952380952381 27.2 27 2 abnormal salivary gland morphology 0.0301352325739813 0.0967868186285067 0.562629968545827 0.80952380952381 27.2 27 2 increased keratinocyte proliferation 0.0301352325739813 0.0967868186285067 0.562629968545827 0.80952380952381 27.2 27 2 abnormal tumor vascularization 0.0301352325739813 0.0967868186285067 0.562629968545827 0.80952380952381 27.2 27 2 vascular ring 0.0301352325739813 0.0967868186285067 0.562629968545827 0.80952380952381 27.2 27 2 lung inflammation 4.27708941313397e-08 6.99951310208602e-07 0.562143264420788 0.808823529411765 27.2 27 2 hepatic necrosis 0.0012641281473915 0.00719569511816102 0.561925800875557 0.808510638297872 27.2 27 2 abnormal T-helper 1 physiology 0.0012641281473915 0.00719569511816102 0.561925800875557 0.808510638297872 27.2 27 2 increased respiratory quotient 0.0012641281473915 0.00719569511816102 0.561925800875557 0.808510638297872 27.2 27 2 abnormal hair growth 0.000732093735317132 0.00451881679057411 0.561357050064955 0.807692307692308 27.2 27 2 decreased body temperature 0.000732093735317132 0.00451881679057411 0.561357050064955 0.807692307692308 27.2 27 2 abnormal kidney cortex morphology 0.0166968698651161 0.0599761209956336 0.561357050064955 0.807692307692308 27.2 27 2 abnormal Schwann cell morphology 0.0166968698651161 0.0599761209956336 0.561357050064955 0.807692307692308 27.2 27 2 decreased circulating glycerol level 0.0166968698651161 0.0599761209956336 0.561357050064955 0.807692307692308 27.2 27 2 decreased susceptibility to induced arthritis 0.000425504343764539 0.00282628052099944 0.560888080098317 0.807017543859649 27.2 27 2 decreased neuronal precursor cell number 0.00938240444784279 0.038323039513972 0.560494750448879 0.806451612903226 27.2 27 2 abnormal CD8-positive, alpha beta T cell morphology 0.00938240444784279 0.038323039513972 0.560494750448879 0.806451612903226 27.2 27 2 abnormal femur morphology 0.000144978303667331 0.00110285483294338 0.560160126717268 0.805970149253731 27.2 27 2 abnormal uterus morphology 0.0053257283264166 0.0239561468570729 0.559871978503936 0.805555555555556 27.2 27 2 abnormal epidermis stratum granulosum morphology 0.0053257283264166 0.0239561468570729 0.559871978503936 0.805555555555556 27.2 27 2 obese 4.98355609995077e-05 0.000424540952007792 0.559621252136491 0.805194805194805 27.2 27 2 scaly skin 0.00304610207605039 0.0150340851471733 0.559401102155321 0.804878048780488 27.2 27 2 cochlear inner hair cell degeneration 0.00101317711309025 0.00601498345778519 0.55873633554551 0.803921568627451 27.2 27 2 abnormal seminal vesicle morphology 0.000587996926451638 0.00377943760865232 0.55849298348299 0.803571428571429 27.2 27 2 abnormal T cell differentiation 4.86253415295118e-06 5.34020031146405e-05 0.557387056783024 0.801980198019802 27.2 27 2 decreased IgG level 1.69999371831764e-06 2.09343285857184e-05 0.55726306900485 0.801801801801802 27.2 27 2 increased circulating glucose level 7.38663459603307e-08 1.17407370975286e-06 0.556996627183666 0.801418439716312 27.2 27 2 increased body length 0.00139638766668018 0.00788539005872179 0.556010792445288 0.8 27.2 27 2 increased susceptibility to weight loss 0.00421130444858196 0.0199916408699382 0.556010792445288 0.8 27.2 27 2 abnormal hair cycle 0.0130342646993143 0.0511399581065369 0.556010792445288 0.8 27.2 27 2 arrested T cell differentiation 0.0130342646993143 0.0511399581065369 0.556010792445288 0.8 27.2 27 2 abnormal fat pad morphology 0.0130342646993143 0.0511399581065369 0.556010792445288 0.8 27.2 27 2 ruffled hair 0.0232789950100159 0.0809315165442551 0.556010792445288 0.8 27.2 27 2 abnormal thyroid gland morphology 0.0232789950100159 0.0809315165442551 0.556010792445288 0.8 27.2 27 2 decreased acute inflammation 0.0232789950100159 0.0809315165442551 0.556010792445288 0.8 27.2 27 2 abnormal trachea morphology 0.0422243808324761 0.120797179207342 0.556010792445288 0.8 27.2 27 2 abnormal Peyer's patch T cell area morphology 0.0422243808324761 0.120797179207342 0.556010792445288 0.8 27.2 27 2 decreased skin tensile strength 0.0422243808324761 0.120797179207342 0.556010792445288 0.8 27.2 27 2 absent placental labyrinth 0.0422243808324761 0.120797179207342 0.556010792445288 0.8 27.2 27 2 abnormal male reproductive system physiology 0.0422243808324761 0.120797179207342 0.556010792445288 0.8 27.2 27 2 abnormal physiological neovascularization 0.0422243808324761 0.120797179207342 0.556010792445288 0.8 27.2 27 2 enhanced behavioral response to xenobiotic 0.0422243808324761 0.120797179207342 0.556010792445288 0.8 27.2 27 2 decreased hepatocyte number 0.0784118714054214 0.193982625679747 0.556010792445288 0.8 27.2 27 2 vagina atresia 0.0784118714054214 0.193982625679747 0.556010792445288 0.8 27.2 27 2 abnormal epidermis stratum spinosum morphology 0.0784118714054214 0.193982625679747 0.556010792445288 0.8 27.2 27 2 absent egg cylinders 0.0784118714054214 0.193982625679747 0.556010792445288 0.8 27.2 27 2 increased airway responsiveness 0.0784118714054214 0.193982625679747 0.556010792445288 0.8 27.2 27 2 abnormal respiratory system morphology 0.0784118714054214 0.193982625679747 0.556010792445288 0.8 27.2 27 2 abnormal bronchus morphology 0.0784118714054214 0.193982625679747 0.556010792445288 0.8 27.2 27 2 dilated ureter 0.0784118714054214 0.193982625679747 0.556010792445288 0.8 27.2 27 2 abnormal olfactory nerve morphology 0.0784118714054214 0.193982625679747 0.556010792445288 0.8 27.2 27 2 immune system phenotype 0.0784118714054214 0.193982625679747 0.556010792445288 0.8 27.2 27 2 abnormal dendritic cell morphology 0.0784118714054214 0.193982625679747 0.556010792445288 0.8 27.2 27 2 kidney hemorrhage 0.151610328136204 0.306984689653079 0.556010792445288 0.8 27.2 27 2 abnormal prostate gland epithelium morphology 0.151610328136204 0.306984689653079 0.556010792445288 0.8 27.2 27 2 abnormal gland morphology 0.151610328136204 0.306984689653079 0.556010792445288 0.8 27.2 27 2 abnormal primordial germ cell migration 0.151610328136204 0.306984689653079 0.556010792445288 0.8 27.2 27 2 primary sex reversal 0.151610328136204 0.306984689653079 0.556010792445288 0.8 27.2 27 2 abnormal bone healing 0.151610328136204 0.306984689653079 0.556010792445288 0.8 27.2 27 2 delayed dark adaptation 0.151610328136204 0.306984689653079 0.556010792445288 0.8 27.2 27 2 abnormal hypaxial muscle morphology 0.151610328136204 0.306984689653079 0.556010792445288 0.8 27.2 27 2 lymphedema 0.151610328136204 0.306984689653079 0.556010792445288 0.8 27.2 27 2 increased atrioventricular cushion size 0.151610328136204 0.306984689653079 0.556010792445288 0.8 27.2 27 2 ascites 0.151610328136204 0.306984689653079 0.556010792445288 0.8 27.2 27 2 increased susceptibility to atherosclerosis 0.151610328136204 0.306984689653079 0.556010792445288 0.8 27.2 27 2 decreased thyroxine level 0.151610328136204 0.306984689653079 0.556010792445288 0.8 27.2 27 2 abnormal sperm principal piece morphology 0.151610328136204 0.306984689653079 0.556010792445288 0.8 27.2 27 2 increased serotonin level 0.151610328136204 0.306984689653079 0.556010792445288 0.8 27.2 27 2 increased circulating fructosamine level 0.151610328136204 0.306984689653079 0.556010792445288 0.8 27.2 27 2 increased T-helper 17 cell number 0.151610328136204 0.306984689653079 0.556010792445288 0.8 27.2 27 2 sinus bradycardia 0.151610328136204 0.306984689653079 0.556010792445288 0.8 27.2 27 2 abnormal circadian temperature homeostasis 0.151610328136204 0.306984689653079 0.556010792445288 0.8 27.2 27 2 hyperkeratosis 0.000219809750706017 0.00158027963838502 0.553996260588602 0.797101449275362 27.2 27 2 abnormal colon morphology 0.000645118128674134 0.00401684942447286 0.553654814511198 0.796610169491525 27.2 27 2 polyphagia 0.00110988676228961 0.00647325514934445 0.55343666840619 0.796296296296296 27.2 27 2 abnormal epidermis stratum corneum morphology 0.00191627249440704 0.0102290296777629 0.553174002687914 0.795918367346939 27.2 27 2 increased fluid intake 0.00191627249440704 0.0102290296777629 0.553174002687914 0.795918367346939 27.2 27 2 hypertension 0.00332273375728634 0.016383152073835 0.552851640215485 0.795454545454545 27.2 27 2 acanthosis 0.00579191665659312 0.0258685358937879 0.552446620698844 0.794871794871795 27.2 27 2 increased vascular permeability 0.00579191665659312 0.0258685358937879 0.552446620698844 0.794871794871795 27.2 27 2 impaired macrophage chemotaxis 0.00579191665659312 0.0258685358937879 0.552446620698844 0.794871794871795 27.2 27 2 decreased osteoblast cell number 0.010163191264184 0.0410071991397529 0.551922477794955 0.794117647058823 27.2 27 2 abnormal hair follicle morphology 0.000513205678924549 0.00332015377457689 0.551598008378262 0.793650793650794 27.2 27 2 skin lesions 0.000513205678924549 0.00332015377457689 0.551598008378262 0.793650793650794 27.2 27 2 abnormal eye electrophysiology 1.65695633647393e-06 2.04549820693742e-05 0.551415661929212 0.793388429752066 27.2 27 2 glomerulosclerosis 0.000880604244035411 0.00533618284296732 0.551217595958691 0.793103448275862 27.2 27 2 abnormal circulating glucose level 0.0179875397276122 0.0645191132983927 0.551217595958691 0.793103448275862 27.2 27 2 increased retinal apoptosis 0.0179875397276122 0.0645191132983927 0.551217595958691 0.793103448275862 27.2 27 2 abnormal intestinal epithelium morphology 0.00261796436447832 0.0134417054979315 0.550219013357316 0.791666666666667 27.2 27 2 decreased ovulation rate 0.0322063252540552 0.10330526636939 0.550219013357316 0.791666666666667 27.2 27 2 abnormal inner cell mass apoptosis 0.0322063252540552 0.10330526636939 0.550219013357316 0.791666666666667 27.2 27 2 small ovary 3.87137596514909e-05 0.000337896410993275 0.549900783737098 0.791208791208791 27.2 27 2 abnormal trabecular bone morphology 3.03173935864357e-06 3.49141280306754e-05 0.549002253044718 0.789915966386555 27.2 27 2 abnormal retinal outer nuclear layer morphology 0.00792224962132673 0.0337153052746796 0.548694860965745 0.789473684210526 27.2 27 2 irregular coat pigmentation 0.0586200199166705 0.162742521811069 0.548694860965745 0.789473684210526 27.2 27 2 abnormal nail morphology 0.0586200199166705 0.162742521811069 0.548694860965745 0.789473684210526 27.2 27 2 enlarged adrenal glands 0.0586200199166705 0.162742521811069 0.548694860965745 0.789473684210526 27.2 27 2 short vibrissae 0.0586200199166705 0.162742521811069 0.548694860965745 0.789473684210526 27.2 27 2 decreased grooming behavior 0.0586200199166705 0.162742521811069 0.548694860965745 0.789473684210526 27.2 27 2 osteoarthritis 0.0586200199166705 0.162742521811069 0.548694860965745 0.789473684210526 27.2 27 2 oliguria 0.0586200199166705 0.162742521811069 0.548694860965745 0.789473684210526 27.2 27 2 increased circulating VLDL cholesterol level 0.0586200199166705 0.162742521811069 0.548694860965745 0.789473684210526 27.2 27 2 eyelids fail to open 0.0586200199166705 0.162742521811069 0.548694860965745 0.789473684210526 27.2 27 2 decreased susceptibility to weight gain 0.0586200199166705 0.162742521811069 0.548694860965745 0.789473684210526 27.2 27 2 thin interventricular septum 0.0586200199166705 0.162742521811069 0.548694860965745 0.789473684210526 27.2 27 2 abnormal leukocyte migration 0.00206085152115369 0.0109537781172432 0.547991406015789 0.788461538461538 27.2 27 2 increased susceptibility to injury 0.00206085152115369 0.0109537781172432 0.547991406015789 0.788461538461538 27.2 27 2 absent vibrissae 0.0139124823312083 0.0544996847226467 0.547586386499148 0.787878787878788 27.2 27 2 decreased systemic arterial blood pressure 0.0139124823312083 0.0544996847226467 0.547586386499148 0.787878787878788 27.2 27 2 increased systemic arterial blood pressure 0.00355996383474445 0.0174147690047725 0.547138279799885 0.787234042553192 27.2 27 2 abnormal cytotoxic T cell physiology 0.0061765018705227 0.0272896063995119 0.54608202829448 0.785714285714286 27.2 27 2 abnormal spleen germinal center morphology 0.0246479606424188 0.0826918098293303 0.546082028294479 0.785714285714286 27.2 27 2 abnormal hormone level 0.0246479606424188 0.0826918098293303 0.546082028294479 0.785714285714286 27.2 27 2 abnormal fluid regulation 0.109417483257303 0.253249291664555 0.546082028294479 0.785714285714286 27.2 27 2 abnormal antigen presentation 0.109417483257303 0.253249291664555 0.546082028294479 0.785714285714286 27.2 27 2 increased lactate dehydrogenase level 0.109417483257303 0.253249291664555 0.546082028294479 0.785714285714286 27.2 27 2 abnormal kidney medulla morphology 0.109417483257303 0.253249291664555 0.546082028294479 0.785714285714286 27.2 27 2 abnormal prepulse inhibition 0.109417483257303 0.253249291664555 0.546082028294479 0.785714285714286 27.2 27 2 abnormal uterus development 0.109417483257303 0.253249291664555 0.546082028294479 0.785714285714286 27.2 27 2 vascular smooth muscle hypoplasia 0.109417483257303 0.253249291664555 0.546082028294479 0.785714285714286 27.2 27 2 abnormal sagittal suture morphology 0.109417483257303 0.253249291664555 0.546082028294479 0.785714285714286 27.2 27 2 abnormal decidualization 0.109417483257303 0.253249291664555 0.546082028294479 0.785714285714286 27.2 27 2 abnormal squamosal bone morphology 0.109417483257303 0.253249291664555 0.546082028294479 0.785714285714286 27.2 27 2 increased B-1 B cell number 0.109417483257303 0.253249291664555 0.546082028294479 0.785714285714286 27.2 27 2 increased circulating growth hormone level 0.109417483257303 0.253249291664555 0.546082028294479 0.785714285714286 27.2 27 2 abnormal renal reabsorbtion 0.109417483257303 0.253249291664555 0.546082028294479 0.785714285714286 27.2 27 2 increased stomach tumor incidence 0.109417483257303 0.253249291664555 0.546082028294479 0.785714285714286 27.2 27 2 abnormal response to infection 0.000203207819284164 0.00149108982439338 0.545453625500125 0.784810126582278 27.2 27 2 decreased monocyte cell number 0.000745660728716901 0.00455732447833733 0.545318277205956 0.784615384615385 27.2 27 2 abnormal T cell activation 0.000345414850142533 0.00235725497868189 0.544740303409235 0.783783783783784 27.2 27 2 abnormal pancreatic beta cell physiology 0.0107739329697444 0.0428117544125228 0.544740303409235 0.783783783783784 27.2 27 2 liver inflammation 5.88114523405024e-06 6.30575378004309e-05 0.544427234269345 0.783333333333333 27.2 27 2 bidirectional circling 0.0441880828767998 0.126052587334908 0.543923601305173 0.782608695652174 27.2 27 2 abnormal postnatal growth 0.0441880828767998 0.126052587334908 0.543923601305173 0.782608695652174 27.2 27 2 abnormal B cell morphology 0.0441880828767998 0.126052587334908 0.543923601305173 0.782608695652174 27.2 27 2 polydipsia 0.0189209154730204 0.0671409090429931 0.542979289497352 0.78125 27.2 27 2 abnormal lumbar vertebrae morphology 0.0189209154730204 0.0671409090429931 0.542979289497352 0.78125 27.2 27 2 abnormal systemic arterial blood pressure 0.0145636328072079 0.0547429859217487 0.540566048210697 0.777777777777778 27.2 27 2 rectal prolapse 0.0335202727395495 0.10694904923392 0.540566048210697 0.777777777777778 27.2 27 2 wrinkled skin 0.0335202727395495 0.10694904923392 0.540566048210697 0.777777777777778 27.2 27 2 abnormal single cell response 0.0335202727395495 0.10694904923392 0.540566048210697 0.777777777777778 27.2 27 2 abnormal bone trabecula morphology 0.0335202727395495 0.10694904923392 0.540566048210697 0.777777777777778 27.2 27 2 cortical renal glomerulopathies 0.0805632097778393 0.198318638616898 0.540566048210697 0.777777777777778 27.2 27 2 right pulmonary isomerism 0.0805632097778393 0.198318638616898 0.540566048210697 0.777777777777778 27.2 27 2 eye inflammation 0.0805632097778393 0.198318638616898 0.540566048210697 0.777777777777778 27.2 27 2 abnormal white adipose tissue morphology 0.0805632097778393 0.198318638616898 0.540566048210697 0.777777777777778 27.2 27 2 decreased activity of thyroid 0.0805632097778393 0.198318638616898 0.540566048210697 0.777777777777778 27.2 27 2 decreased tumor latency 0.0805632097778393 0.198318638616898 0.540566048210697 0.777777777777778 27.2 27 2 abnormal aerobic respiration 0.0805632097778393 0.198318638616898 0.540566048210697 0.777777777777778 27.2 27 2 abnormal head movements 0.213351852267878 0.378249029540625 0.540566048210697 0.777777777777778 27.2 27 2 crypts of Lieberkuhn abscesses 0.213351852267878 0.378249029540625 0.540566048210697 0.777777777777778 27.2 27 2 deformed nails 0.213351852267878 0.378249029540625 0.540566048210697 0.777777777777778 27.2 27 2 abnormal sympathetic neuron morphology 0.213351852267878 0.378249029540625 0.540566048210697 0.777777777777778 27.2 27 2 small geniculate ganglion 0.213351852267878 0.378249029540625 0.540566048210697 0.777777777777778 27.2 27 2 wavy vibrissae 0.213351852267878 0.378249029540625 0.540566048210697 0.777777777777778 27.2 27 2 abnormal lens vesicle development 0.213351852267878 0.378249029540625 0.540566048210697 0.777777777777778 27.2 27 2 increased pheochromocytoma incidence 0.213351852267878 0.378249029540625 0.540566048210697 0.777777777777778 27.2 27 2 abnormal germ cell morphology 0.213351852267878 0.378249029540625 0.540566048210697 0.777777777777778 27.2 27 2 abnormal laryngeal cartilage morphology 0.213351852267878 0.378249029540625 0.540566048210697 0.777777777777778 27.2 27 2 long gestation period 0.213351852267878 0.378249029540625 0.540566048210697 0.777777777777778 27.2 27 2 abnormal postural reflex 0.213351852267878 0.378249029540625 0.540566048210697 0.777777777777778 27.2 27 2 enlarged otoliths 0.213351852267878 0.378249029540625 0.540566048210697 0.777777777777778 27.2 27 2 abnormal lens capsule morphology 0.213351852267878 0.378249029540625 0.540566048210697 0.777777777777778 27.2 27 2 abnormal ovary physiology 0.213351852267878 0.378249029540625 0.540566048210697 0.777777777777778 27.2 27 2 abnormal bony labyrinth 0.213351852267878 0.378249029540625 0.540566048210697 0.777777777777778 27.2 27 2 absent cochlear outer hair cells 0.213351852267878 0.378249029540625 0.540566048210697 0.777777777777778 27.2 27 2 decreased thyroid-stimulating hormone level 0.213351852267878 0.378249029540625 0.540566048210697 0.777777777777778 27.2 27 2 abnormal oxygen consumption 0.213351852267878 0.378249029540625 0.540566048210697 0.777777777777778 27.2 27 2 absent adrenal gland 0.213351852267878 0.378249029540625 0.540566048210697 0.777777777777778 27.2 27 2 abnormal retinal development 0.213351852267878 0.378249029540625 0.540566048210697 0.777777777777778 27.2 27 2 multiflagellated sperm 0.213351852267878 0.378249029540625 0.540566048210697 0.777777777777778 27.2 27 2 decreased susceptibility to parasitic infection induced morbidity/mortality 0.213351852267878 0.378249029540625 0.540566048210697 0.777777777777778 27.2 27 2 abnormal pulmonary alveolar system morphology 0.213351852267878 0.378249029540625 0.540566048210697 0.777777777777778 27.2 27 2 decreased bone trabecular spacing 0.213351852267878 0.378249029540625 0.540566048210697 0.777777777777778 27.2 27 2 decreased fatty acid oxidation 0.213351852267878 0.378249029540625 0.540566048210697 0.777777777777778 27.2 27 2 enhanced leukocyte tethering or rolling 0.213351852267878 0.378249029540625 0.540566048210697 0.777777777777778 27.2 27 2 albuminuria 0.00648623099149084 0.0284177659278042 0.540566048210697 0.777777777777778 27.2 27 2 maternal effect 0.00105385199736251 0.00616088564850584 0.539413455357369 0.776119402985075 27.2 27 2 abnormal dendritic cell physiology 3.94191739433205e-05 0.000342310518098529 0.539122614170081 0.775700934579439 27.2 27 2 decreased urine osmolality 0.00504199082472457 0.0229980985286793 0.538990053901045 0.775510204081633 27.2 27 2 increased eosinophil cell number 0.00179332101244331 0.00961344560051086 0.538074960430924 0.774193548387097 27.2 27 2 abnormal T cell proliferation 0.0255549284186454 0.084870339708118 0.538074960430924 0.774193548387097 27.2 27 2 decreased inflammatory response 0.000301859921937747 0.00209871337763816 0.537808058168806 0.773809523809524 27.2 27 2 increased liver weight 0.000237519248164662 0.00169329086510598 0.537055879066472 0.772727272727273 27.2 27 2 abnormal circadian rhythm 0.00868706240067212 0.0355412298053814 0.537055879066472 0.772727272727273 27.2 27 2 abnormal abdominal fat pad morphology 0.0600849982250501 0.166397449904859 0.537055879066472 0.772727272727273 27.2 27 2 decreased circulating estradiol level 0.0600849982250501 0.166397449904859 0.537055879066472 0.772727272727273 27.2 27 2 decreased susceptibility to viral infection induced morbidity/mortality 0.0600849982250501 0.166397449904859 0.537055879066472 0.772727272727273 27.2 27 2 abnormal intestinal goblet cell morphology 0.0195612003185554 0.0693634865180422 0.536153264143671 0.771428571428571 27.2 27 2 abnormal male meiosis 0.00238360339502929 0.0125618928922359 0.535502197641978 0.770491803278688 27.2 27 2 increased B cell number 3.39094852443661e-05 0.000299644207976415 0.534625761966623 0.769230769230769 27.2 27 2 small lens 0.0150233595037721 0.0553591703450083 0.534625761966623 0.769230769230769 27.2 27 2 increased autoantibody level 0.0150233595037721 0.0553591703450083 0.534625761966623 0.769230769230769 27.2 27 2 abnormal circulating hormone level 0.0150233595037721 0.0553591703450083 0.534625761966623 0.769230769230769 27.2 27 2 abnormal stomach morphology 0.0452194121596817 0.128846835907455 0.534625761966623 0.769230769230769 27.2 27 2 abnormal ocular fundus morphology 0.0452194121596817 0.128846835907455 0.534625761966623 0.769230769230769 27.2 27 2 abnormal membranous labyrinth morphology 0.15071423560994 0.306984689653079 0.534625761966623 0.769230769230769 27.2 27 2 absent common myeloid progenitor cells 0.15071423560994 0.306984689653079 0.534625761966623 0.769230769230769 27.2 27 2 absent myocardial trabeculae 0.15071423560994 0.306984689653079 0.534625761966623 0.769230769230769 27.2 27 2 abnormal sympathetic ganglion morphology 0.15071423560994 0.306984689653079 0.534625761966623 0.769230769230769 27.2 27 2 uterus hypoplasia 0.15071423560994 0.306984689653079 0.534625761966623 0.769230769230769 27.2 27 2 abnormal intercostal muscle morphology 0.15071423560994 0.306984689653079 0.534625761966623 0.769230769230769 27.2 27 2 abnormal insulin secretion 0.15071423560994 0.306984689653079 0.534625761966623 0.769230769230769 27.2 27 2 vestibular hair cell degeneration 0.15071423560994 0.306984689653079 0.534625761966623 0.769230769230769 27.2 27 2 increased circulating thyroid-stimulating hormone level 0.15071423560994 0.306984689653079 0.534625761966623 0.769230769230769 27.2 27 2 increased circulating ammonia level 0.15071423560994 0.306984689653079 0.534625761966623 0.769230769230769 27.2 27 2 increased circulating thyroxine level 0.15071423560994 0.306984689653079 0.534625761966623 0.769230769230769 27.2 27 2 orthokeratosis 0.15071423560994 0.306984689653079 0.534625761966623 0.769230769230769 27.2 27 2 empty decidua capsularis 0.15071423560994 0.306984689653079 0.534625761966623 0.769230769230769 27.2 27 2 abnormal intestinal mucosa morphology 0.0115706901616634 0.0459410882316643 0.53338244624112 0.767441860465116 27.2 27 2 increased metastatic potential 0.0342625862491622 0.108226264501322 0.532843676093401 0.766666666666667 27.2 27 2 abnormal microglial cell physiology 0.0342625862491622 0.108226264501322 0.532843676093401 0.766666666666667 27.2 27 2 increased neutrophil cell number 6.45634308490089e-06 6.86331342892777e-05 0.532044810012302 0.76551724137931 27.2 27 2 abnormal thrombosis 0.00691076529624996 0.0295878290437552 0.53148090454329 0.764705882352941 27.2 27 2 abnormal oocyte morphology 0.0260976782990372 0.0849155981279988 0.53148090454329 0.764705882352941 27.2 27 2 thin skin 0.0260976782990372 0.0849155981279988 0.53148090454329 0.764705882352941 27.2 27 2 abnormal vision 0.0260976782990372 0.0849155981279988 0.53148090454329 0.764705882352941 27.2 27 2 decreased cytotoxic T cell cytolysis 0.0260976782990372 0.0849155981279988 0.53148090454329 0.764705882352941 27.2 27 2 increased susceptibility to weight gain 0.0260976782990372 0.0849155981279988 0.53148090454329 0.764705882352941 27.2 27 2 increased susceptibility to viral infection induced morbidity/mortality 0.0260976782990372 0.0849155981279988 0.53148090454329 0.764705882352941 27.2 27 2 nephrocalcinosis 0.109495321883509 0.253249291664555 0.53148090454329 0.764705882352941 27.2 27 2 pancytopenia 0.109495321883509 0.253249291664555 0.53148090454329 0.764705882352941 27.2 27 2 abnormal tendon morphology 0.109495321883509 0.253249291664555 0.53148090454329 0.764705882352941 27.2 27 2 abnormal circulating chemokine level 0.109495321883509 0.253249291664555 0.53148090454329 0.764705882352941 27.2 27 2 abnormal electroretinogram waveform feature 0.109495321883509 0.253249291664555 0.53148090454329 0.764705882352941 27.2 27 2 abnormal T-helper 2 physiology 0.00535603691071178 0.0240707169203172 0.530737574606866 0.763636363636364 27.2 27 2 abnormal vibrissa morphology 0.015323028128176 0.0562183369746871 0.529534088043132 0.761904761904762 27.2 27 2 hypoalgesia 0.080909655259659 0.199072964845106 0.529534088043132 0.761904761904762 27.2 27 2 delayed wound healing 0.0117959495889457 0.046760836019924 0.52881461238003 0.760869565217391 27.2 27 2 dermatitis 0.00545468108581513 0.0244919119150995 0.527251613525704 0.758620689655172 27.2 27 2 decreased granulocyte number 0.0455807120889535 0.129653540676126 0.527251613525704 0.758620689655172 27.2 27 2 decreased retinal photoreceptor cell number 0.0455807120889535 0.129653540676126 0.527251613525704 0.758620689655172 27.2 27 2 diarrhea 0.0345722690411834 0.109065972403226 0.526525371633796 0.757575757575758 27.2 27 2 impaired fertilization 0.00256010796440937 0.0134417054979315 0.526224499992862 0.757142857142857 27.2 27 2 increased white adipose tissue amount 0.0263538100793163 0.085636972661397 0.525956155015813 0.756756756756757 27.2 27 2 skin inflammation 0.0263538100793163 0.085636972661397 0.525956155015813 0.756756756756757 27.2 27 2 increased urine protein level 0.00155544342795038 0.00877361797511695 0.525715332600513 0.756410256410256 27.2 27 2 decreased osteoclast cell number 0.0154896322108688 0.0567877083633548 0.525121303976106 0.755555555555556 27.2 27 2 increased sensitivity to induced morbidity/mortality 1.75878916871034e-06 2.14987128116313e-05 0.525037365148744 0.755434782608696 27.2 27 2 abnormal cytokine secretion 1.54926494696958e-05 0.000147091471587284 0.52351665522446 0.753246753246753 27.2 27 2 increased percent body fat/body weight 0.0119831287418073 0.0473895592134271 0.521260117917458 0.75 27.2 27 2 increased food intake 0.0015886257628365 0.00887027291819481 0.521260117917458 0.75 27.2 27 2 abnormal inflammatory response 0.00335553377966394 0.0165284955978496 0.521260117917458 0.75 27.2 27 2 decreased eosinophil cell number 0.00555654349164627 0.0249267843741571 0.521260117917458 0.75 27.2 27 2 abnormal photoreceptor outer segment morphology 0.0202215734446371 0.0716540796916451 0.521260117917458 0.75 27.2 27 2 abnormal crypts of Lieberkuhn morphology 0.0454569672555204 0.129449577616608 0.521260117917458 0.75 27.2 27 2 abnormal stria vascularis morphology 0.0601372090309419 0.166397449904859 0.521260117917458 0.75 27.2 27 2 corneal vascularization 0.0601372090309419 0.166397449904859 0.521260117917458 0.75 27.2 27 2 abnormal foregut morphology 0.0801333557450343 0.197946099717749 0.521260117917458 0.75 27.2 27 2 abnormal primitive streak formation 0.0801333557450343 0.197946099717749 0.521260117917458 0.75 27.2 27 2 waved hair 0.107806937169253 0.251566375430129 0.521260117917458 0.75 27.2 27 2 brain inflammation 0.107806937169253 0.251566375430129 0.521260117917458 0.75 27.2 27 2 abnormal fibula morphology 0.107806937169253 0.251566375430129 0.521260117917458 0.75 27.2 27 2 mixed cellular infiltration to dermis 0.147000437922406 0.301702631462034 0.521260117917458 0.75 27.2 27 2 abnormal intestinal absorption 0.147000437922406 0.301702631462034 0.521260117917458 0.75 27.2 27 2 large intestinal inflammation 0.147000437922406 0.301702631462034 0.521260117917458 0.75 27.2 27 2 increased pancreatic beta cell number 0.147000437922406 0.301702631462034 0.521260117917458 0.75 27.2 27 2 small epididymis 0.147000437922406 0.301702631462034 0.521260117917458 0.75 27.2 27 2 abnormal level of surface class II molecules 0.147000437922406 0.301702631462034 0.521260117917458 0.75 27.2 27 2 sepsis 0.147000437922406 0.301702631462034 0.521260117917458 0.75 27.2 27 2 abnormal pulmonary alveolus wall morphology 0.147000437922406 0.301702631462034 0.521260117917458 0.75 27.2 27 2 abnormal mineral level 0.204562856878865 0.369046276286859 0.521260117917458 0.75 27.2 27 2 abnormal esophagus morphology 0.204562856878865 0.369046276286859 0.521260117917458 0.75 27.2 27 2 abnormal rectum morphology 0.204562856878865 0.369046276286859 0.521260117917458 0.75 27.2 27 2 abnormal pilomotor reflex 0.204562856878865 0.369046276286859 0.521260117917458 0.75 27.2 27 2 abnormal embryonic growth/weight/body size 0.204562856878865 0.369046276286859 0.521260117917458 0.75 27.2 27 2 abnormal tracheal ciliated epithelium morphology 0.204562856878865 0.369046276286859 0.521260117917458 0.75 27.2 27 2 increased fear-related response 0.204562856878865 0.369046276286859 0.521260117917458 0.75 27.2 27 2 increased hepatocyte proliferation 0.204562856878865 0.369046276286859 0.521260117917458 0.75 27.2 27 2 vestibular saccular macula degeneration 0.204562856878865 0.369046276286859 0.521260117917458 0.75 27.2 27 2 abnormal palatine bone morphology 0.204562856878865 0.369046276286859 0.521260117917458 0.75 27.2 27 2 abnormal patella morphology 0.204562856878865 0.369046276286859 0.521260117917458 0.75 27.2 27 2 abnormal thymus corticomedullary boundary morphology 0.204562856878865 0.369046276286859 0.521260117917458 0.75 27.2 27 2 increased type II pneumocyte number 0.204562856878865 0.369046276286859 0.521260117917458 0.75 27.2 27 2 abnormal respiratory motile cilium morphology 0.204562856878865 0.369046276286859 0.521260117917458 0.75 27.2 27 2 decreased compensatory feeding amount 0.204562856878865 0.369046276286859 0.521260117917458 0.75 27.2 27 2 failure of vascular branching 0.294751217724363 0.500644352399694 0.521260117917458 0.75 27.2 27 2 unidirectional circling 0.294751217724363 0.500644352399694 0.521260117917458 0.75 27.2 27 2 abnormal drinking behavior 0.294751217724363 0.500644352399694 0.521260117917458 0.75 27.2 27 2 abnormal circulating calcium level 0.294751217724363 0.500644352399694 0.521260117917458 0.75 27.2 27 2 abnormal urination 0.294751217724363 0.500644352399694 0.521260117917458 0.75 27.2 27 2 abnormal respiratory mucosa goblet cell morphology 0.294751217724363 0.500644352399694 0.521260117917458 0.75 27.2 27 2 abnormal parturition 0.294751217724363 0.500644352399694 0.521260117917458 0.75 27.2 27 2 hypospadia 0.294751217724363 0.500644352399694 0.521260117917458 0.75 27.2 27 2 abnormal soft palate morphology 0.294751217724363 0.500644352399694 0.521260117917458 0.75 27.2 27 2 loss of GABAergic neurons 0.294751217724363 0.500644352399694 0.521260117917458 0.75 27.2 27 2 decreased circulating renin level 0.294751217724363 0.500644352399694 0.521260117917458 0.75 27.2 27 2 abnormal thermosensation 0.294751217724363 0.500644352399694 0.521260117917458 0.75 27.2 27 2 abnormal miscarriage rate 0.294751217724363 0.500644352399694 0.521260117917458 0.75 27.2 27 2 bowed fibula 0.294751217724363 0.500644352399694 0.521260117917458 0.75 27.2 27 2 abnormal canal of Schlemm morphology 0.294751217724363 0.500644352399694 0.521260117917458 0.75 27.2 27 2 choroidal neovascularization 0.294751217724363 0.500644352399694 0.521260117917458 0.75 27.2 27 2 abnormal corneocyte envelope morphology 0.294751217724363 0.500644352399694 0.521260117917458 0.75 27.2 27 2 hypergranulosis 0.294751217724363 0.500644352399694 0.521260117917458 0.75 27.2 27 2 enlarged inguinal lymph nodes 0.294751217724363 0.500644352399694 0.521260117917458 0.75 27.2 27 2 skin fibrosis 0.294751217724363 0.500644352399694 0.521260117917458 0.75 27.2 27 2 decreased serotonin level 0.294751217724363 0.500644352399694 0.521260117917458 0.75 27.2 27 2 heart right ventricle hypoplasia 0.294751217724363 0.500644352399694 0.521260117917458 0.75 27.2 27 2 myocardial trabeculae hypoplasia 0.294751217724363 0.500644352399694 0.521260117917458 0.75 27.2 27 2 abnormal heart right ventricle pressure 0.294751217724363 0.500644352399694 0.521260117917458 0.75 27.2 27 2 abnormal stomach position or orientation 0.294751217724363 0.500644352399694 0.521260117917458 0.75 27.2 27 2 decreased lung compliance 0.294751217724363 0.500644352399694 0.521260117917458 0.75 27.2 27 2 abnormal bronchus epithelium morphology 0.294751217724363 0.500644352399694 0.521260117917458 0.75 27.2 27 2 abnormal branching involved in ureteric bud morphogenesis 0.294751217724363 0.500644352399694 0.521260117917458 0.75 27.2 27 2 decreased surfactant secretion 0.294751217724363 0.500644352399694 0.521260117917458 0.75 27.2 27 2 abnormal macrophage activation involved in immune response 0.294751217724363 0.500644352399694 0.521260117917458 0.75 27.2 27 2 absent Reichert's membrane 0.294751217724363 0.500644352399694 0.521260117917458 0.75 27.2 27 2 increased circulating ferritin level 0.294751217724363 0.500644352399694 0.521260117917458 0.75 27.2 27 2 shortened PQ interval 0.294751217724363 0.500644352399694 0.521260117917458 0.75 27.2 27 2 increased circulating lactate level 0.294751217724363 0.500644352399694 0.521260117917458 0.75 27.2 27 2 increased testis apoptosis 0.294751217724363 0.500644352399694 0.521260117917458 0.75 27.2 27 2 increased mammary gland apoptosis 0.294751217724363 0.500644352399694 0.521260117917458 0.75 27.2 27 2 decreased circulating calcium level 0.0119720806966636 0.047383533385761 0.518100965687655 0.745454545454545 27.2 27 2 abnormal response/metabolism to endogenous compounds 0.00262371684827825 0.0134566920826642 0.517022230779917 0.74390243902439 27.2 27 2 abnormal leukocyte adhesion 0.034286750099514 0.108233871665661 0.516804903234403 0.743589743589744 27.2 27 2 abnormal immune system physiology 0.000289498797403181 0.00202853030574764 0.515655170412969 0.741935483870968 27.2 27 2 decreased susceptibility to bacterial infection induced morbidity/mortality 0.0592971025118978 0.16453044338912 0.515655170412969 0.741935483870968 27.2 27 2 abnormal retinal cone cell morphology 0.105126258378426 0.247887955863528 0.513705623454886 0.739130434782609 27.2 27 2 abnormal circulating insulin level 0.105126258378426 0.247887955863528 0.513705623454886 0.739130434782609 27.2 27 2 increased susceptibility to age related obesity 0.105126258378426 0.247887955863528 0.513705623454886 0.739130434782609 27.2 27 2 abnormal lens development 0.105126258378426 0.247887955863528 0.513705623454886 0.739130434782609 27.2 27 2 abnormal hepatocyte physiology 0.105126258378426 0.247887955863528 0.513705623454886 0.739130434782609 27.2 27 2 abnormal NK cell physiology 0.0117949535638578 0.046760836019924 0.512714870082745 0.737704918032787 27.2 27 2 decreased fertilization frequency 0.142004141389112 0.300386345548786 0.512115203568029 0.736842105263158 27.2 27 2 decreased circulating magnesium level 0.142004141389112 0.300386345548786 0.512115203568029 0.736842105263158 27.2 27 2 right-sided stomach 0.142004141389112 0.300386345548786 0.512115203568029 0.736842105263158 27.2 27 2 increased inflammatory response 0.00201925863656817 0.0107556870630906 0.512115203568029 0.736842105263158 27.2 27 2 increased susceptibility to bacterial infection induced morbidity/mortality 0.00703560697314312 0.0300964270777189 0.511607152770838 0.736111111111111 27.2 27 2 abnormal retinal photoreceptor morphology 0.0581127988804779 0.16233081102211 0.511039331291625 0.735294117647059 27.2 27 2 altered response to myocardial infarction 0.0332344118375002 0.106397167883889 0.509676559741514 0.733333333333333 27.2 27 2 gastrointestinal hemorrhage 0.0767055581483801 0.190805075894096 0.509676559741514 0.733333333333333 27.2 27 2 abnormal spleen marginal zone morphology 0.0767055581483801 0.190805075894096 0.509676559741514 0.733333333333333 27.2 27 2 arthritis 0.194682915849977 0.369046276286859 0.509676559741514 0.733333333333333 27.2 27 2 abnormal aorta wall morphology 0.194682915849977 0.369046276286859 0.509676559741514 0.733333333333333 27.2 27 2 abnormal microglial cell activation 0.194682915849977 0.369046276286859 0.509676559741514 0.733333333333333 27.2 27 2 decreased trabecular bone mass 0.194682915849977 0.369046276286859 0.509676559741514 0.733333333333333 27.2 27 2 increased tumor growth/size 0.0433326316736786 0.123825297286933 0.508546456504837 0.731707317073171 27.2 27 2 decreased IgA level 0.025089974849105 0.0833818469434186 0.507894473868292 0.730769230769231 27.2 27 2 abnormal leukocyte cell number 0.101887497475816 0.241836975163257 0.507894473868292 0.730769230769231 27.2 27 2 small seminal vesicle 0.101887497475816 0.241836975163257 0.507894473868292 0.730769230769231 27.2 27 2 decreased Peyer's patch number 0.101887497475816 0.241836975163257 0.507894473868292 0.730769230769231 27.2 27 2 abnormal hair shaft morphology 0.0325320394848378 0.104215644840353 0.506780670197528 0.729166666666667 27.2 27 2 abnormal ovarian folliculogenesis 0.0744828291604198 0.18546149903558 0.505464356768444 0.727272727272727 27.2 27 2 abnormal gametogenesis 0.0422851789270814 0.120901589173695 0.505464356768444 0.727272727272727 27.2 27 2 intestinal ulcer 0.136442074018617 0.289466660231394 0.505464356768444 0.727272727272727 27.2 27 2 increased activated T cell number 0.136442074018617 0.289466660231394 0.505464356768444 0.727272727272727 27.2 27 2 intestinal inflammation 0.136442074018617 0.289466660231394 0.505464356768444 0.727272727272727 27.2 27 2 abnormal retinal layer morphology 0.136442074018617 0.289466660231394 0.505464356768444 0.727272727272727 27.2 27 2 abnormal circulating lipid level 0.136442074018617 0.289466660231394 0.505464356768444 0.727272727272727 27.2 27 2 abnormal sperm midpiece morphology 0.136442074018617 0.289466660231394 0.505464356768444 0.727272727272727 27.2 27 2 rough coat 0.136442074018617 0.289466660231394 0.505464356768444 0.727272727272727 27.2 27 2 increased bone volume 0.136442074018617 0.289466660231394 0.505464356768444 0.727272727272727 27.2 27 2 abnormal ear position 0.273021610920345 0.469668919200801 0.505464356768444 0.727272727272727 27.2 27 2 focal hepatic necrosis 0.273021610920345 0.469668919200801 0.505464356768444 0.727272727272727 27.2 27 2 abnormal primary sex determination 0.273021610920345 0.469668919200801 0.505464356768444 0.727272727272727 27.2 27 2 dilated renal glomerular capsule 0.273021610920345 0.469668919200801 0.505464356768444 0.727272727272727 27.2 27 2 abnormal crista ampullaris neuroepithelium morphology 0.273021610920345 0.469668919200801 0.505464356768444 0.727272727272727 27.2 27 2 decreased palatine bone horizontal plate size 0.273021610920345 0.469668919200801 0.505464356768444 0.727272727272727 27.2 27 2 increased number of Howell-Jolly bodies 0.273021610920345 0.469668919200801 0.505464356768444 0.727272727272727 27.2 27 2 abnormal extraembryonic ectoderm morphology 0.273021610920345 0.469668919200801 0.505464356768444 0.727272727272727 27.2 27 2 increased subcutaneous adipose tissue amount 0.273021610920345 0.469668919200801 0.505464356768444 0.727272727272727 27.2 27 2 decreased core body temperature 0.273021610920345 0.469668919200801 0.505464356768444 0.727272727272727 27.2 27 2 decreased colon length 0.273021610920345 0.469668919200801 0.505464356768444 0.727272727272727 27.2 27 2 increased susceptibility to induced arthritis 0.0983480135036618 0.23377036176814 0.503285631092718 0.724137931034483 27.2 27 2 abnormal CD8-positive, alpha-beta T cell physiology 0.0983480135036618 0.23377036176814 0.503285631092718 0.724137931034483 27.2 27 2 polychromatophilia 0.0983480135036618 0.23377036176814 0.503285631092718 0.724137931034483 27.2 27 2 abnormal megakaryocyte differentiation 0.184718813358251 0.369046276286859 0.501954187624219 0.722222222222222 27.2 27 2 abnormal neutrophil morphology 0.184718813358251 0.369046276286859 0.501954187624219 0.722222222222222 27.2 27 2 abnormal sperm axoneme morphology 0.184718813358251 0.369046276286859 0.501954187624219 0.722222222222222 27.2 27 2 abnormal macrophage chemotaxis 0.184718813358251 0.369046276286859 0.501954187624219 0.722222222222222 27.2 27 2 impaired macrophage phagocytosis 0.0534452100078636 0.150475336609576 0.501056237378022 0.720930232558139 27.2 27 2 decreased placenta weight 0.130680316448946 0.278191944515835 0.500409713200759 0.72 27.2 27 2 increased dopamine level 0.0946663370559731 0.229114248039038 0.499540946337564 0.71875 27.2 27 2 abnormal lens fiber morphology 0.0696072596796 0.180181923264312 0.498984044502182 0.717948717948718 27.2 27 2 abnormal response to injury 0.0696072596796 0.180181923264312 0.498984044502182 0.717948717948718 27.2 27 2 abnormal humoral immune response 0.00556419936731414 0.0249386413084575 0.496438207540436 0.714285714285714 27.2 27 2 increased acute inflammation 0.17505014194324 0.35387015691492 0.496438207540436 0.714285714285714 27.2 27 2 abnormal zigzag hair morphology 0.253956116491535 0.438843931762899 0.496438207540436 0.714285714285714 27.2 27 2 abnormal olfactory system physiology 0.253956116491535 0.438843931762899 0.496438207540436 0.714285714285714 27.2 27 2 decreased vascular permeability 0.253956116491535 0.438843931762899 0.496438207540436 0.714285714285714 27.2 27 2 abnormal imprinting 0.253956116491535 0.438843931762899 0.496438207540436 0.714285714285714 27.2 27 2 enlarged stomach 0.253956116491535 0.438843931762899 0.496438207540436 0.714285714285714 27.2 27 2 abnormal pancreas development 0.253956116491535 0.438843931762899 0.496438207540436 0.714285714285714 27.2 27 2 abnormal iris pigmentation 0.253956116491535 0.438843931762899 0.496438207540436 0.714285714285714 27.2 27 2 cochlear degeneration 0.398232434132809 0.571776727218102 0.496438207540436 0.714285714285714 27.2 27 2 mottled coat 0.398232434132809 0.571776727218102 0.496438207540436 0.714285714285714 27.2 27 2 increased chemically-elicited antinociception 0.398232434132809 0.571776727218102 0.496438207540436 0.714285714285714 27.2 27 2 decreased urine calcium level 0.398232434132809 0.571776727218102 0.496438207540436 0.714285714285714 27.2 27 2 calcinosis 0.398232434132809 0.571776727218102 0.496438207540436 0.714285714285714 27.2 27 2 increased muscle weight 0.398232434132809 0.571776727218102 0.496438207540436 0.714285714285714 27.2 27 2 abnormal locus ceruleus morphology 0.398232434132809 0.571776727218102 0.496438207540436 0.714285714285714 27.2 27 2 abnormal hard palate morphology 0.398232434132809 0.571776727218102 0.496438207540436 0.714285714285714 27.2 27 2 abnormal organ of Corti supporting cell morphology 0.398232434132809 0.571776727218102 0.496438207540436 0.714285714285714 27.2 27 2 abnormal cochlear hair cell physiology 0.398232434132809 0.571776727218102 0.496438207540436 0.714285714285714 27.2 27 2 increased prostate gland weight 0.398232434132809 0.571776727218102 0.496438207540436 0.714285714285714 27.2 27 2 abnormal ciliary body morphology 0.398232434132809 0.571776727218102 0.496438207540436 0.714285714285714 27.2 27 2 decreased adrenocorticotropin level 0.398232434132809 0.571776727218102 0.496438207540436 0.714285714285714 27.2 27 2 urolithiasis 0.398232434132809 0.571776727218102 0.496438207540436 0.714285714285714 27.2 27 2 abnormal renal/urinary system physiology 0.398232434132809 0.571776727218102 0.496438207540436 0.714285714285714 27.2 27 2 abnormal body temperature 0.398232434132809 0.571776727218102 0.496438207540436 0.714285714285714 27.2 27 2 absent popliteal lymph nodes 0.398232434132809 0.571776727218102 0.496438207540436 0.714285714285714 27.2 27 2 increased DN3 thymocyte number 0.398232434132809 0.571776727218102 0.496438207540436 0.714285714285714 27.2 27 2 abnormal tricarboxylic acid cycle 0.398232434132809 0.571776727218102 0.496438207540436 0.714285714285714 27.2 27 2 abnormal tectorial membrane striated-sheet matrix morphology 0.398232434132809 0.571776727218102 0.496438207540436 0.714285714285714 27.2 27 2 increased abdominal adipose tissue amount 0.398232434132809 0.571776727218102 0.496438207540436 0.714285714285714 27.2 27 2 hypopigmentation 0.165823307630948 0.335354046936571 0.492301222477599 0.708333333333333 27.2 27 2 increased circulating total protein level 0.165823307630948 0.335354046936571 0.492301222477599 0.708333333333333 27.2 27 2 decreased susceptibility to injury 0.0324748554695382 0.104099488376902 0.49059775803996 0.705882352941177 27.2 27 2 decreased pancreatic beta cell number 0.11377090183228 0.258083460660431 0.49059775803996 0.705882352941177 27.2 27 2 delayed heart development 0.237012716415759 0.410563462454179 0.49059775803996 0.705882352941177 27.2 27 2 decreased sensitivity to induced morbidity/mortality 0.0800575918158835 0.197946099717749 0.48966859561943 0.704545454545455 27.2 27 2 abnormal estrous cycle 0.148847075999318 0.305366681689323 0.486509443389627 0.7 27.2 27 2 decreased circulating phosphate level 0.103412171770253 0.24522190398332 0.486509443389627 0.7 27.2 27 2 impaired ovarian folliculogenesis 0.103412171770253 0.24522190398332 0.486509443389627 0.7 27.2 27 2 abnormal thymocyte activation 0.221797617902115 0.384474964830321 0.486509443389627 0.7 27.2 27 2 nuclear cataracts 0.221797617902115 0.384474964830321 0.486509443389627 0.7 27.2 27 2 abnormal otic capsule morphology 0.357415408575118 0.516901644668956 0.486509443389627 0.7 27.2 27 2 abnormal pituitary secretion 0.357415408575118 0.516901644668956 0.486509443389627 0.7 27.2 27 2 abnormal mammary gland physiology 0.357415408575118 0.516901644668956 0.486509443389627 0.7 27.2 27 2 alcohol preference 0.357415408575118 0.516901644668956 0.486509443389627 0.7 27.2 27 2 abnormal airway responsiveness 0.357415408575118 0.516901644668956 0.486509443389627 0.7 27.2 27 2 decreased circulating parathyroid hormone level 0.357415408575118 0.516901644668956 0.486509443389627 0.7 27.2 27 2 rickets 0.357415408575118 0.516901644668956 0.486509443389627 0.7 27.2 27 2 abnormal scala media morphology 0.357415408575118 0.516901644668956 0.486509443389627 0.7 27.2 27 2 abnormal glial cell physiology 0.357415408575118 0.516901644668956 0.486509443389627 0.7 27.2 27 2 abnormal submandibular gland morphology 0.357415408575118 0.516901644668956 0.486509443389627 0.7 27.2 27 2 increased left ventricle diastolic pressure 0.357415408575118 0.516901644668956 0.486509443389627 0.7 27.2 27 2 abnormal placental transport 0.357415408575118 0.516901644668956 0.486509443389627 0.7 27.2 27 2 decreased prolactin level 0.357415408575118 0.516901644668956 0.486509443389627 0.7 27.2 27 2 increased platelet aggregation 0.357415408575118 0.516901644668956 0.486509443389627 0.7 27.2 27 2 crystalluria 0.357415408575118 0.516901644668956 0.486509443389627 0.7 27.2 27 2 decreased macrophage apoptosis 0.357415408575118 0.516901644668956 0.486509443389627 0.7 27.2 27 2 pancreas inflammation 0.208021081196195 0.373477040400963 0.483487645604599 0.695652173913043 27.2 27 2 decreased epididymis weight 0.208021081196195 0.373477040400963 0.483487645604599 0.695652173913043 27.2 27 2 abnormal regulatory T cell physiology 0.208021081196195 0.373477040400963 0.483487645604599 0.695652173913043 27.2 27 2 abnormal tectorial membrane morphology 0.195464159138488 0.369046276286859 0.481163185769961 0.692307692307692 27.2 27 2 abnormal digestion 0.325722254733946 0.506008560069589 0.481163185769961 0.692307692307692 27.2 27 2 increased circulating adrenocorticotropin level 0.325722254733946 0.506008560069589 0.481163185769961 0.692307692307692 27.2 27 2 lymphoid hypoplasia 0.325722254733946 0.506008560069589 0.481163185769961 0.692307692307692 27.2 27 2 abnormal otolith morphology 0.325722254733946 0.506008560069589 0.481163185769961 0.692307692307692 27.2 27 2 abnormal afterhyperpolarization 0.325722254733946 0.506008560069589 0.481163185769961 0.692307692307692 27.2 27 2 decreased alcohol consumption 0.325722254733946 0.506008560069589 0.481163185769961 0.692307692307692 27.2 27 2 decreased luteinizing hormone level 0.325722254733946 0.506008560069589 0.481163185769961 0.692307692307692 27.2 27 2 increased renin activity 0.325722254733946 0.506008560069589 0.481163185769961 0.692307692307692 27.2 27 2 stomach inflammation 0.183956982358833 0.369046276286859 0.479319648659731 0.689655172413793 27.2 27 2 enlarged epididymis 0.183956982358833 0.369046276286859 0.479319648659731 0.689655172413793 27.2 27 2 abnormal wound healing 0.299584367290632 0.506008560069589 0.47782177475767 0.6875 27.2 27 2 abnormal Langerhans cell physiology 0.299584367290632 0.506008560069589 0.47782177475767 0.6875 27.2 27 2 abnormal digestive system physiology 0.124028822799896 0.26414528828317 0.472609173578495 0.68 27.2 27 2 decreased circulating progesterone level 0.225003460394057 0.389896278460617 0.471616297163414 0.678571428571429 27.2 27 2 abnormal body temperature homeostasis 0.210980857885681 0.378249029540625 0.470815590377059 0.67741935483871 27.2 27 2 abnormal intestine physiology 0.210980857885681 0.378249029540625 0.470815590377059 0.67741935483871 27.2 27 2 abnormal skin physiology 0.198206821381173 0.369046276286859 0.470156184788295 0.676470588235294 27.2 27 2 abnormal immune system morphology 0.156579825848579 0.316918077134532 0.468378656679455 0.673913043478261 27.2 27 2 cryptorchism 0.272218112199699 0.469668919200801 0.46334232703774 0.666666666666667 27.2 27 2 salivary gland inflammation 0.254176795077862 0.439072762330681 0.46334232703774 0.666666666666667 27.2 27 2 abnormal cellular extravasation 0.292416628326689 0.500644352399694 0.46334232703774 0.666666666666667 27.2 27 2 abnormal Peyer's patch follicle morphology 0.341600522530776 0.506008560069589 0.46334232703774 0.666666666666667 27.2 27 2 increased vasoconstriction 0.315292569819865 0.506008560069589 0.46334232703774 0.666666666666667 27.2 27 2 increased bone ossification 0.315292569819865 0.506008560069589 0.46334232703774 0.666666666666667 27.2 27 2 joint inflammation 0.37250251777465 0.538407909915422 0.46334232703774 0.666666666666667 27.2 27 2 increased alcohol consumption 0.37250251777465 0.538407909915422 0.46334232703774 0.666666666666667 27.2 27 2 increased circulating parathyroid hormone level 0.409939119003303 0.587736921337589 0.46334232703774 0.666666666666667 27.2 27 2 abnormal gastrocnemius morphology 0.409939119003303 0.587736921337589 0.46334232703774 0.666666666666667 27.2 27 2 abnormal nucleotide metabolism 0.409939119003303 0.587736921337589 0.46334232703774 0.666666666666667 27.2 27 2 decreased oligodendrocyte number 0.409939119003303 0.587736921337589 0.46334232703774 0.666666666666667 27.2 27 2 abnormal aorta elastic tissue morphology 0.409939119003303 0.587736921337589 0.46334232703774 0.666666666666667 27.2 27 2 abnormal vagina orifice morphology 0.457549948637332 0.631256782799052 0.46334232703774 0.666666666666667 27.2 27 2 psoriasis 0.457549948637332 0.631256782799052 0.46334232703774 0.666666666666667 27.2 27 2 multifocal hepatic necrosis 0.457549948637332 0.631256782799052 0.46334232703774 0.666666666666667 27.2 27 2 yellow coat color 0.457549948637332 0.631256782799052 0.46334232703774 0.666666666666667 27.2 27 2 priapism 0.457549948637332 0.631256782799052 0.46334232703774 0.666666666666667 27.2 27 2 impaired febrile response 0.457549948637332 0.631256782799052 0.46334232703774 0.666666666666667 27.2 27 2 decreased cochlear hair cell number 0.457549948637332 0.631256782799052 0.46334232703774 0.666666666666667 27.2 27 2 abnormal hair cell mechanoelectric transduction 0.457549948637332 0.631256782799052 0.46334232703774 0.666666666666667 27.2 27 2 increased circulating progesterone level 0.457549948637332 0.631256782799052 0.46334232703774 0.666666666666667 27.2 27 2 increased stomach mucosa thickness 0.457549948637332 0.631256782799052 0.46334232703774 0.666666666666667 27.2 27 2 decreased pulmonary ventilation 0.457549948637332 0.631256782799052 0.46334232703774 0.666666666666667 27.2 27 2 abnormal incisor color 0.457549948637332 0.631256782799052 0.46334232703774 0.666666666666667 27.2 27 2 abnormal pulmonary alveolar parenchyma morphology 0.457549948637332 0.631256782799052 0.46334232703774 0.666666666666667 27.2 27 2 increased bone mineralization 0.457549948637332 0.631256782799052 0.46334232703774 0.666666666666667 27.2 27 2 adipose tissue inflammation 0.457549948637332 0.631256782799052 0.46334232703774 0.666666666666667 27.2 27 2 conjunctivitis 0.351082906451003 0.510265106512924 0.453269667754311 0.652173913043478 27.2 27 2 impaired natural killer cell mediated cytotoxicity 0.22055512699937 0.382587781318642 0.451149107905168 0.649122807017544 27.2 27 2 enlarged sebaceous gland 0.414299060561231 0.593816717456677 0.44971461153663 0.647058823529412 27.2 27 2 increased circulating luteinizing hormone level 0.357204485449853 0.516901644668956 0.446794386786392 0.642857142857143 27.2 27 2 abnormal positive T cell selection 0.454901303570288 0.631256782799052 0.446794386786392 0.642857142857143 27.2 27 2 abnormal respiratory motile cilium physiology 0.454901303570288 0.631256782799052 0.446794386786392 0.642857142857143 27.2 27 2 increased pre-B cell number 0.384709009542669 0.55572802627026 0.444808633956231 0.64 27.2 27 2 abnormal stomach mucosa morphology 0.384709009542669 0.55572802627026 0.444808633956231 0.64 27.2 27 2 abnormal female reproductive system physiology 0.415936563886622 0.595820444957082 0.442281312172388 0.636363636363636 27.2 27 2 increased mast cell number 0.505104554470971 0.657499974114603 0.442281312172388 0.636363636363636 27.2 27 2 abnormal large intestine morphology 0.505104554470971 0.657499974114603 0.442281312172388 0.636363636363636 27.2 27 2 vasculitis 0.505104554470971 0.657499974114603 0.442281312172388 0.636363636363636 27.2 27 2 abnormal Bruch membrane morphology 0.505104554470971 0.657499974114603 0.442281312172388 0.636363636363636 27.2 27 2 flaky skin 0.451886099512589 0.631256782799052 0.438955888772596 0.631578947368421 27.2 27 2 altered susceptibility to infection 0.451886099512589 0.631256782799052 0.438955888772596 0.631578947368421 27.2 27 2 decreased liver glycogen level 0.451886099512589 0.631256782799052 0.438955888772596 0.631578947368421 27.2 27 2 decreased susceptibility to parasitic infection 0.415916946361053 0.595820444957082 0.434383431597882 0.625 27.2 27 2 absent pre-B cells 0.570701128146886 0.657499974114603 0.434383431597882 0.625 27.2 27 2 abnormal pituitary gland morphology 0.494032768581348 0.657499974114603 0.434383431597882 0.625 27.2 27 2 spinning 0.570701128146886 0.657499974114603 0.434383431597882 0.625 27.2 27 2 joint swelling 0.570701128146886 0.657499974114603 0.434383431597882 0.625 27.2 27 2 vascular smooth muscle hypertrophy 0.570701128146886 0.657499974114603 0.434383431597882 0.625 27.2 27 2 abnormal umbilical artery morphology 0.570701128146886 0.657499974114603 0.434383431597882 0.625 27.2 27 2 urinary incontinence 0.570701128146886 0.657499974114603 0.434383431597882 0.625 27.2 27 2 abnormal perineum morphology 0.570701128146886 0.657499974114603 0.434383431597882 0.625 27.2 27 2 abnormal platelet shape 0.570701128146886 0.657499974114603 0.434383431597882 0.625 27.2 27 2 hair follicle degeneration 0.570701128146886 0.657499974114603 0.434383431597882 0.625 27.2 27 2 pulmonary interstitial fibrosis 0.570701128146886 0.657499974114603 0.434383431597882 0.625 27.2 27 2 thin stria vascularis 0.570701128146886 0.657499974114603 0.434383431597882 0.625 27.2 27 2 abnormal epididymis epithelium morphology 0.494032768581348 0.657499974114603 0.434383431597882 0.625 27.2 27 2 increased circulating prolactin level 0.570701128146886 0.657499974114603 0.434383431597882 0.625 27.2 27 2 abnormal pancreatic alpha cell morphology 0.494032768581348 0.657499974114603 0.434383431597882 0.625 27.2 27 2 abnormal intestinal lipid absorption 0.494032768581348 0.657499974114603 0.434383431597882 0.625 27.2 27 2 decreased susceptibility to autoimmune disorder 0.570701128146886 0.657499974114603 0.434383431597882 0.625 27.2 27 2 abnormal mast cell differentiation 0.570701128146886 0.657499974114603 0.434383431597882 0.625 27.2 27 2 abnormal thymus epithelium morphology 0.570701128146886 0.657499974114603 0.434383431597882 0.625 27.2 27 2 urinary bladder inflammation 0.570701128146886 0.657499974114603 0.434383431597882 0.625 27.2 27 2 decreased susceptibility to weight loss 0.570701128146886 0.657499974114603 0.434383431597882 0.625 27.2 27 2 abnormal urinary bladder physiology 0.494032768581348 0.657499974114603 0.434383431597882 0.625 27.2 27 2 impaired mucociliary clearance 0.570701128146886 0.657499974114603 0.434383431597882 0.625 27.2 27 2 small thymus medulla 0.570701128146886 0.657499974114603 0.434383431597882 0.625 27.2 27 2 curly vibrissae 0.448860036658191 0.631256782799052 0.434383431597881 0.625 27.2 27 2 dry skin 0.485890706455297 0.657499974114603 0.430246446535045 0.619047619047619 27.2 27 2 abnormal gut flora balance 0.544686101834275 0.657499974114603 0.427700609573299 0.615384615384615 27.2 27 2 abnormal hair follicle inner root sheath morphology 0.544686101834275 0.657499974114603 0.427700609573299 0.615384615384615 27.2 27 2 autoimmune response 0.473748532193573 0.652699791654119 0.425976010341148 0.612903225806452 27.2 27 2 thick dermal layer 0.528539620323375 0.657499974114603 0.424730466451262 0.611111111111111 27.2 27 2 abnormal iron level 0.528539620323375 0.657499974114603 0.424730466451262 0.611111111111111 27.2 27 2 greasy coat 0.578499482263743 0.657499974114603 0.417008094333966 0.6 27.2 27 2 lactation failure 0.578499482263743 0.657499974114603 0.417008094333966 0.6 27.2 27 2 increased susceptibility to parasitic infection 0.468106604644563 0.645105362356427 0.417008094333966 0.6 27.2 27 2 increased urine calcium level 0.559291744545714 0.657499974114603 0.417008094333966 0.6 27.2 27 2 increased natural killer cell mediated cytotoxicity 0.607751758730653 0.676867024778375 0.417008094333966 0.6 27.2 27 2 absent inguinal lymph nodes 0.607751758730653 0.676867024778375 0.417008094333966 0.6 27.2 27 2 absent axillary lymph nodes 0.607751758730653 0.676867024778375 0.417008094333966 0.6 27.2 27 2 increased urine phosphate level 0.638336164125705 0.694906436876452 0.405424536158023 0.583333333333333 27.2 27 2 abnormal anogenital distance 0.638336164125705 0.694906436876452 0.405424536158023 0.583333333333333 27.2 27 2 abnormal bile salt homeostasis 0.657159795332937 0.715241737427557 0.397150566032349 0.571428571428571 27.2 27 2 increased circulating estradiol level 0.687099542712538 0.743436325575223 0.390945088438093 0.5625 27.2 27 2 increased susceptibility to autoimmune disorder 0.707186122539903 0.763178082350546 0.386118605864784 0.555555555555556 27.2 27 2 brittle hair 0.712140102533829 0.768191025608369 0.386118605864784 0.555555555555556 27.2 27 2 absent cervical lymph nodes 0.712140102533829 0.768191025608369 0.386118605864784 0.555555555555556 27.2 27 2 enlarged placenta 0.730928403842272 0.788287190356667 0.379098267576333 0.545454545454545 27.2 27 2 abnormal mast cell morphology 0.747594570132375 0.805737215426465 0.374238033376636 0.538461538461538 27.2 27 2 decreased follicle stimulating hormone level 0.747594570132375 0.805737215426465 0.374238033376636 0.538461538461538 27.2 27 2 total cataracts 0.747594570132375 0.805737215426465 0.374238033376636 0.538461538461538 27.2 27 2 abnormal fertilization 0.838040924340008 0.868413580210694 0.347506745278305 0.5 27.2 27 2 increased litter size 0.82352064355884 0.862208015903551 0.347506745278305 0.5 27.2 27 2 abnormal hair cuticle 0.830789974078492 0.862208015903551 0.347506745278305 0.5 27.2 27 2 absent cochlear hair cells 0.82352064355884 0.862208015903551 0.347506745278305 0.5 27.2 27 2 abnormal circulating cytokine level 0.851972598776775 0.88266632213962 0.347506745278305 0.5 27.2 27 2 decreased airway responsiveness 0.85854528015572 0.889290603534188 0.347506745278305 0.5 27.2 27 2 abnormal feces composition 0.905929537199105 0.9352561625992 0.333606475467173 0.48 27.2 27 2 increased susceptibility to fungal infection 0.902558939983942 0.933714020881703 0.332397756353161 0.478260869565217 27.2 27 2 increased placenta weight 0.933819794742449 0.958677977474966 0.289588954398588 0.416666666666667 27.2 27 2 decreased T-helper 17 cell number 0.000125969392045249 0.00382132759405558 4.30213930852682 0.857142857142857 28.1 28 1 abnormal lymph node cortex morphology 0.000653374104622306 0.0137734583495592 4.18263543884552 0.833333333333333 28.1 28 1 abnormal immature B cell morphology 0.000653374104622306 0.0137734583495592 4.18263543884552 0.833333333333333 28.1 28 1 absent brachial lymph nodes 0.000653374104622306 0.0137734583495592 4.18263543884552 0.833333333333333 28.1 28 1 decreased level of surface class I molecules 9.16446955664254e-05 0.00305994872780514 3.90379307625582 0.777777777777778 28.1 28 1 absent cervical lymph nodes 9.16446955664254e-05 0.00305994872780514 3.90379307625582 0.777777777777778 28.1 28 1 abnormal tumor incidence 0.00197188588606495 0.0314427316768369 3.58511609043901 0.714285714285714 28.1 28 1 decreased mortality induced by ionizing radiation 0.00197188588606495 0.0314427316768369 3.58511609043901 0.714285714285714 28.1 28 1 absent popliteal lymph nodes 0.00197188588606495 0.0314427316768369 3.58511609043901 0.714285714285714 28.1 28 1 heart hemorrhage 0.00197188588606495 0.0314427316768369 3.58511609043901 0.714285714285714 28.1 28 1 decreased DN2 thymocyte number 0.00197188588606495 0.0314427316768369 3.58511609043901 0.714285714285714 28.1 28 1 decreased DN4 thymocyte number 0.00197188588606495 0.0314427316768369 3.58511609043901 0.714285714285714 28.1 28 1 absent inguinal lymph nodes 0.000261361021544319 0.0067024282586752 3.51341376863023 0.7 28.1 28 1 absent axillary lymph nodes 0.000261361021544319 0.0067024282586752 3.51341376863023 0.7 28.1 28 1 abnormal Peyer's patch follicle morphology 3.00821523584089e-06 0.000154287327817613 3.34610835107641 0.666666666666667 28.1 28 1 interstitial pneumonia 0.000151450706643991 0.0044583861867092 3.34610835107641 0.666666666666667 28.1 28 1 increased neuronal precursor cell number 0.00111401222585777 0.0206798911329941 3.34610835107641 0.666666666666667 28.1 28 1 abnormal Peyer's patch T cell area morphology 1.75258507317757e-06 0.000100219663667338 3.2624556422995 0.65 28.1 28 1 abnormal spleen periarteriolar lymphoid sheath morphology 8.58051931030945e-05 0.00290395126318296 3.22660448139511 0.642857142857143 28.1 28 1 increased hemangioma incidence 8.58051931030945e-05 0.00290395126318296 3.22660448139511 0.642857142857143 28.1 28 1 increased B-1 B cell number 8.58051931030945e-05 0.00290395126318296 3.22660448139511 0.642857142857143 28.1 28 1 loss of cortex neurons 0.000615228619017688 0.0133076625200565 3.19401251693658 0.636363636363636 28.1 28 1 arrested B cell differentiation 2.42485649694318e-11 4.02122035743078e-09 3.18288355346293 0.634146341463415 28.1 28 1 absent pre-B cells 0.00453763924228951 0.0607616087737635 3.13697657913414 0.625 28.1 28 1 abnormal kidney epithelium morphology 0.00453763924228951 0.0607616087737635 3.13697657913414 0.625 28.1 28 1 increased caudal vertebrae number 0.00453763924228951 0.0607616087737635 3.13697657913414 0.625 28.1 28 1 abnormal heart echocardiography feature 0.00453763924228951 0.0607616087737635 3.13697657913414 0.625 28.1 28 1 increased brain apoptosis 0.00453763924228951 0.0607616087737635 3.13697657913414 0.625 28.1 28 1 abnormal B cell morphology 2.17899093028957e-06 0.000117831303023811 3.05514240750455 0.608695652173913 28.1 28 1 increased pre-B cell number 1.21254162267269e-06 7.44740070715634e-05 3.01149751596877 0.6 28.1 28 1 decreased transitional stage T2 B cell number 0.00239298903232794 0.0364070961340413 3.01149751596877 0.6 28.1 28 1 abnormal B cell differentiation 4.05146409285024e-20 2.24088784649977e-17 2.97840413667241 0.593406593406593 28.1 28 1 decreased B-1 B cell number 2.71317859535029e-09 3.06774170724265e-07 2.96001892595221 0.58974358974359 28.1 28 1 abnormal adipose tissue morphology 9.91082158952911e-05 0.00324383798736232 2.95244854506742 0.588235294117647 28.1 28 1 increased mortality induced by gamma-irradiation 3.71805465004822e-07 2.56907248388749e-05 2.94226768801547 0.586206896551724 28.1 28 1 abnormal vascular endothelial cell development 0.00126451769634087 0.0226294084147331 2.92784480719186 0.583333333333333 28.1 28 1 premature aging 1.32589827771879e-06 7.94740232729035e-05 2.86809287235121 0.571428571428571 28.1 28 1 vascular smooth muscle hypoplasia 0.000670075983987519 0.0139482343947193 2.86809287235121 0.571428571428571 28.1 28 1 abnormal maternal decidual layer morphology 0.000670075983987519 0.0139482343947193 2.86809287235121 0.571428571428571 28.1 28 1 testis degeneration 0.000670075983987519 0.0139482343947193 2.86809287235121 0.571428571428571 28.1 28 1 increased intestinal adenocarcinoma incidence 0.000356087958385095 0.00872678617224556 2.82327892122072 0.5625 28.1 28 1 decreased B cell proliferation 3.02482949362256e-15 1.15757897929017e-12 2.79548292621574 0.556962025316456 28.1 28 1 multifocal hepatic necrosis 0.00881717301282919 0.0945375770233302 2.78842362589701 0.555555555555556 28.1 28 1 abnormal thymus physiology 0.00881717301282919 0.0945375770233302 2.78842362589701 0.555555555555556 28.1 28 1 decreased cellular sensitivity to ionizing radiation 0.00881717301282919 0.0945375770233302 2.78842362589701 0.555555555555556 28.1 28 1 decreased transitional stage T1 B cell number 0.00881717301282919 0.0945375770233302 2.78842362589701 0.555555555555556 28.1 28 1 increased skin tumor incidence 0.000101337225236945 0.0032737188022974 2.76053938963804 0.55 28.1 28 1 abnormal mesenteric lymph node morphology 5.42410508060287e-05 0.00201380020716413 2.73772501451707 0.545454545454545 28.1 28 1 delayed hepatic development 0.00452630152830025 0.0607616087737635 2.73772501451707 0.545454545454545 28.1 28 1 increased foot pad pigmentation 0.00234754688800938 0.0358252937664009 2.70262597586941 0.538461538461538 28.1 28 1 increased synaptic depression 0.00234754688800938 0.0358252937664009 2.70262597586941 0.538461538461538 28.1 28 1 placental labyrinth hypoplasia 0.00122699038792377 0.0221169463040606 2.67688668086113 0.533333333333333 28.1 28 1 immune system phenotype 0.00122699038792377 0.0221169463040606 2.67688668086113 0.533333333333333 28.1 28 1 abnormal energy homeostasis 0.00122699038792377 0.0221169463040606 2.67688668086113 0.533333333333333 28.1 28 1 abnormal dendritic cell morphology 0.00122699038792377 0.0221169463040606 2.67688668086113 0.533333333333333 28.1 28 1 enhanced behavioral response to cocaine 0.000645190168686125 0.0137734583495592 2.65720369056068 0.529411764705882 28.1 28 1 abnormal erythrocyte physiology 0.000180845238269898 0.00508307943724714 2.62908513298861 0.523809523809524 28.1 28 1 abnormal germ layer development 0.000307449425733766 0.00768623564334416 2.50958126330731 0.5 28.1 28 1 small lymph nodes 0.00016341818467453 0.00467244522273442 2.50958126330731 0.5 28.1 28 1 increased mammary adenocarcinoma incidence 0.000580476875764718 0.0127219050966056 2.50958126330731 0.5 28.1 28 1 abnormal thymocyte activation 0.000580476875764718 0.0127219050966056 2.50958126330731 0.5 28.1 28 1 absent inner cell mass 0.00110064767377135 0.0205083227603463 2.50958126330731 0.5 28.1 28 1 impaired leukocyte tethering or rolling 0.00110064767377135 0.0205083227603463 2.50958126330731 0.5 28.1 28 1 decreased liver cholesterol level 0.00209789281746244 0.0330285340723912 2.50958126330731 0.5 28.1 28 1 increased stomach tumor incidence 0.00402501779203124 0.0566274139105236 2.50958126330731 0.5 28.1 28 1 decreased response to antigen 0.00402501779203124 0.0566274139105236 2.50958126330731 0.5 28.1 28 1 myocarditis 0.00778808536025964 0.0890983722033736 2.50958126330731 0.5 28.1 28 1 loss of dopaminergic neurons 0.00778808536025964 0.0890983722033736 2.50958126330731 0.5 28.1 28 1 small intestinal inflammation 0.00778808536025964 0.0890983722033736 2.50958126330731 0.5 28.1 28 1 abnormal defecation 0.00778808536025964 0.0890983722033736 2.50958126330731 0.5 28.1 28 1 fused cornea and lens 0.0152413569933304 0.149439622803621 2.50958126330731 0.5 28.1 28 1 acrania 0.0152413569933304 0.149439622803621 2.50958126330731 0.5 28.1 28 1 increased atrioventricular cushion size 0.0152413569933304 0.149439622803621 2.50958126330731 0.5 28.1 28 1 abnormal gas homeostasis 0.0152413569933304 0.149439622803621 2.50958126330731 0.5 28.1 28 1 decreased macrophage cytokine production 0.0152413569933304 0.149439622803621 2.50958126330731 0.5 28.1 28 1 lethality during fetal growth through weaning, complete penetrance 0.0152413569933304 0.149439622803621 2.50958126330731 0.5 28.1 28 1 increased fatty acid oxidation 0.0152413569933304 0.149439622803621 2.50958126330731 0.5 28.1 28 1 abnormal humoral immune response 3.24399077102563e-14 1.00867838036578e-11 2.43787894149853 0.485714285714286 28.1 28 1 decreased trophoblast giant cell number 7.62708579348961e-05 0.00269111715053977 2.42304397836568 0.482758620689655 28.1 28 1 abnormal embryonic erythropoiesis 7.62708579348961e-05 0.00269111715053977 2.42304397836568 0.482758620689655 28.1 28 1 increased B cell derived lymphoma incidence 2.58304239293664e-07 1.88979939777349e-05 2.40919801277502 0.48 28.1 28 1 abnormal cell death 8.77779292567283e-07 5.59865638528491e-05 2.40046903446786 0.478260869565217 28.1 28 1 abnormal myelopoiesis 1.61977259841815e-06 9.59329604420275e-05 2.39550938770243 0.477272727272727 28.1 28 1 abnormal erythropoiesis 1.53540462596307e-13 4.02033579692963e-11 2.39007739362601 0.476190476190476 28.1 28 1 increased bone ossification 0.000943778364396371 0.0182561016021259 2.39007739362601 0.476190476190476 28.1 28 1 increased B cell proliferation 3.60605936805684e-08 3.09312850966944e-06 2.38197543635948 0.474576271186441 28.1 28 1 decreased IgM level 1.70999618694087e-12 3.40289241201233e-10 2.38022140437394 0.474226804123711 28.1 28 1 oliguria 0.00178441423471482 0.0295915360590207 2.37749803892271 0.473684210526316 28.1 28 1 increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 0.00178441423471482 0.0295915360590207 2.37749803892271 0.473684210526316 28.1 28 1 hydrops fetalis 1.5064671039246e-09 1.82796922976216e-07 2.37016008201246 0.472222222222222 28.1 28 1 decreased B cell number 2.06976299773841e-24 2.57426772843715e-21 2.363392063503 0.470873786407767 28.1 28 1 abnormal dorsal-ventral axis patterning 0.00338918406081916 0.0487317650363449 2.36195883605394 0.470588235294118 28.1 28 1 abnormal cell cycle 3.47413949528373e-14 1.01669670523744e-11 2.35682414293208 0.469565217391304 28.1 28 1 increased fibroblast apoptosis 6.51879907944195e-05 0.00235007430581331 2.3527324343506 0.46875 28.1 28 1 macrocytosis 0.00647329177062527 0.077414967689569 2.34227584575349 0.466666666666667 28.1 28 1 abnormal prostate gland morphology 0.00647329177062527 0.077414967689569 2.34227584575349 0.466666666666667 28.1 28 1 abnormal lymph node B cell domain morphology 0.00647329177062527 0.077414967689569 2.34227584575349 0.466666666666667 28.1 28 1 delayed intramembranous bone ossification 0.00647329177062527 0.077414967689569 2.34227584575349 0.466666666666667 28.1 28 1 decreased thymocyte apoptosis 0.00647329177062527 0.077414967689569 2.34227584575349 0.466666666666667 28.1 28 1 increased bone resorption 0.000225638493041059 0.0060352231337595 2.33032545878536 0.464285714285714 28.1 28 1 abnormal cell differentiation 8.69976865587732e-06 0.000404498589373735 2.32595336599214 0.463414634146341 28.1 28 1 extramedullary hematopoiesis 1.09204574204536e-12 2.2637198194482e-10 2.32017890381242 0.462264150943396 28.1 28 1 increased leukemia incidence 0.000420892147678244 0.00973924853348494 2.31653655074521 0.461538461538462 28.1 28 1 small pituitary gland 0.0124514040507599 0.127046203301858 2.31653655074521 0.461538461538462 28.1 28 1 increased trabecular bone volume 2.96242098619126e-05 0.00117904355250412 2.30610170141753 0.459459459459459 28.1 28 1 thymus atrophy 2.16582422504026e-06 0.000117831303023811 2.30044949136503 0.458333333333333 28.1 28 1 increased hemangiosarcoma incidence 0.00078673095046929 0.0155935716278276 2.30044949136503 0.458333333333333 28.1 28 1 increased skin papilloma incidence 0.00147405247994854 0.0258218700272676 2.28143751209755 0.454545454545455 28.1 28 1 prolonged PR interval 0.00147405247994854 0.0258218700272676 2.28143751209755 0.454545454545455 28.1 28 1 abnormal large intestine morphology 0.0241705698808556 0.201069605838702 2.28143751209755 0.454545454545455 28.1 28 1 abnormal food preference 0.0241705698808556 0.201069605838702 2.28143751209755 0.454545454545455 28.1 28 1 abnormal dorsal-ventral polarity of the somites 0.0241705698808556 0.201069605838702 2.28143751209755 0.454545454545455 28.1 28 1 increased number of Howell-Jolly bodies 0.0241705698808556 0.201069605838702 2.28143751209755 0.454545454545455 28.1 28 1 chylous ascites 0.0241705698808556 0.201069605838702 2.28143751209755 0.454545454545455 28.1 28 1 abnormal T cell subpopulation ratio 0.000101196814931065 0.0032737188022974 2.28143751209755 0.454545454545455 28.1 28 1 decreased double-positive T cell number 2.81530531667035e-11 4.51811095175323e-09 2.25862313697658 0.45 28.1 28 1 liver inflammation 3.0747291370183e-13 7.28417974126954e-11 2.25862313697658 0.45 28.1 28 1 spleen hypoplasia 1.29931704177892e-11 2.30860795816075e-09 2.24667275000845 0.447619047619048 28.1 28 1 abnormal megakaryocyte differentiation 0.00522001317045741 0.0649239138075641 2.23073890071761 0.444444444444444 28.1 28 1 abnormal thymus cortex morphology 0.00522001317045741 0.0649239138075641 2.23073890071761 0.444444444444444 28.1 28 1 increased gastrointestinal tumor incidence 0.00522001317045741 0.0649239138075641 2.23073890071761 0.444444444444444 28.1 28 1 increased effector memory CD4-positive, alpha-beta T cell number 0.00522001317045741 0.0649239138075641 2.23073890071761 0.444444444444444 28.1 28 1 increased effector memory CD8-positive, alpha-beta T cell number 0.00522001317045741 0.0649239138075641 2.23073890071761 0.444444444444444 28.1 28 1 increased tumor incidence 3.87941771489092e-13 8.3913491876445e-11 2.22624144325648 0.443548387096774 28.1 28 1 decreased IgA level 2.73858057497079e-06 0.000144940833622124 2.22001419446416 0.442307692307692 28.1 28 1 abnormal direction of heart looping 0.000153365597708854 0.0044781351288453 2.21433640880057 0.441176470588235 28.1 28 1 spontaneous skin ulceration 0.00119521357369162 0.0218609835629257 2.20843151171043 0.44 28.1 28 1 spleen hyperplasia 2.34936636465378e-08 2.16446253039862e-06 2.20843151171043 0.44 28.1 28 1 decreased mast cell number 0.0098763798453075 0.104765436525383 2.1958836053939 0.4375 28.1 28 1 abnormal molar crown morphology 0.0098763798453075 0.104765436525383 2.1958836053939 0.4375 28.1 28 1 abnormal level of surface class II molecules 0.0098763798453075 0.104765436525383 2.1958836053939 0.4375 28.1 28 1 impaired macrophage chemotaxis 6.79498496833687e-05 0.00243201800125726 2.18784007570381 0.435897435897436 28.1 28 1 abnormal allantois morphology 1.65709313291201e-05 0.000716872898803239 2.18224457678897 0.434782608695652 28.1 28 1 abnormal lymphocyte physiology 1.65709313291201e-05 0.000716872898803239 2.18224457678897 0.434782608695652 28.1 28 1 abnormal corneal stroma morphology 0.00222251905466792 0.0343386096179283 2.18224457678897 0.434782608695652 28.1 28 1 abnormal hematopoietic stem cell physiology 0.00222251905466792 0.0343386096179283 2.18224457678897 0.434782608695652 28.1 28 1 abnormal spleen marginal zone morphology 0.000519682799980531 0.0116460447292934 2.17497042819967 0.433333333333333 28.1 28 1 increased T cell derived lymphoma incidence 1.34322647014089e-05 0.000603343634193371 2.15106965426341 0.428571428571429 28.1 28 1 increased carcinoma incidence 0.000227342902063736 0.00604829378485074 2.15106965426341 0.428571428571429 28.1 28 1 trunk curl 0.00413871053776855 0.0580002392264748 2.15106965426341 0.428571428571429 28.1 28 1 lysosomal protein accumulation 0.0187711937448063 0.16826430428903 2.15106965426341 0.428571428571429 28.1 28 1 abnormal T cell differentiation 6.67509682684869e-10 8.30215167839306e-08 2.13687117469731 0.425742574257426 28.1 28 1 abnormal leukocyte cell number 0.00176304928610143 0.0295325595904195 2.12349183818311 0.423076923076923 28.1 28 1 heart inflammation 0.00176304928610143 0.0295325595904195 2.12349183818311 0.423076923076923 28.1 28 1 pulmonary edema 0.00176304928610143 0.0295325595904195 2.12349183818311 0.423076923076923 28.1 28 1 decreased bone resorption 0.00176304928610143 0.0295325595904195 2.12349183818311 0.423076923076923 28.1 28 1 decreased Peyer's patch number 0.00176304928610143 0.0295325595904195 2.12349183818311 0.423076923076923 28.1 28 1 increased liver adenoma incidence 0.00771863057827022 0.0890983722033736 2.11333159015352 0.421052631578947 28.1 28 1 increased left ventricle weight 0.00771863057827022 0.0890983722033736 2.11333159015352 0.421052631578947 28.1 28 1 embryonic lethality between implantation and somite formation, incomplete penetrance 0.00771863057827022 0.0890983722033736 2.11333159015352 0.421052631578947 28.1 28 1 increased macrophage cell number 4.82271557611135e-06 0.000230702019145711 2.11333159015352 0.421052631578947 28.1 28 1 autoimmune response 0.000759741218219047 0.0151468795376493 2.10481009180613 0.419354838709677 28.1 28 1 abnormal definitive hematopoiesis 6.85652379918018e-09 7.25770338317476e-07 2.10481009180613 0.419354838709677 28.1 28 1 increased granulocyte number 2.40735370547944e-07 1.78754995294929e-05 2.10262213952775 0.418918918918919 28.1 28 1 abnormal trophoblast giant cell morphology 0.000330187996317715 0.00817256359045089 2.09131771942276 0.416666666666667 28.1 28 1 increased papilloma incidence 0.035872344538424 0.24447248503926 2.09131771942276 0.416666666666667 28.1 28 1 increased growth rate 0.035872344538424 0.24447248503926 2.09131771942276 0.416666666666667 28.1 28 1 abnormal gastrocnemius morphology 0.035872344538424 0.24447248503926 2.09131771942276 0.416666666666667 28.1 28 1 increased osteosarcoma incidence 0.035872344538424 0.24447248503926 2.09131771942276 0.416666666666667 28.1 28 1 delayed somite formation 0.035872344538424 0.24447248503926 2.09131771942276 0.416666666666667 28.1 28 1 decreased left ventricle systolic pressure 0.035872344538424 0.24447248503926 2.09131771942276 0.416666666666667 28.1 28 1 abnormal B cell proliferation 0.035872344538424 0.24447248503926 2.09131771942276 0.416666666666667 28.1 28 1 abnormal fatty acid level 0.035872344538424 0.24447248503926 2.09131771942276 0.416666666666667 28.1 28 1 abnormal thymus corticomedullary boundary morphology 0.035872344538424 0.24447248503926 2.09131771942276 0.416666666666667 28.1 28 1 decreased keratinocyte proliferation 0.035872344538424 0.24447248503926 2.09131771942276 0.416666666666667 28.1 28 1 decreased mammary gland epithelial cell proliferation 0.035872344538424 0.24447248503926 2.09131771942276 0.416666666666667 28.1 28 1 lordosis 0.00138773472328525 0.0244821994622131 2.07689483859915 0.413793103448276 28.1 28 1 decreased granulocyte number 0.00138773472328525 0.0244821994622131 2.07689483859915 0.413793103448276 28.1 28 1 abnormal immune system morphology 6.35118249946894e-05 0.00230636006823781 2.07313234794952 0.41304347826087 28.1 28 1 failure to gastrulate 6.35118249946894e-05 0.00230636006823781 2.07313234794952 0.41304347826087 28.1 28 1 abnormal spleen red pulp morphology 0.000599308472946669 0.0130199111480772 2.0667139815472 0.411764705882353 28.1 28 1 small liver 2.75671951893761e-07 1.98763472561082e-05 2.05914360066241 0.41025641025641 28.1 28 1 increased hepatocyte apoptosis 0.000260894411184577 0.0067024282586752 2.05914360066241 0.41025641025641 28.1 28 1 increased B cell number 3.25844244901486e-10 4.38128410374296e-08 2.05914360066241 0.41025641025641 28.1 28 1 decreased blood urea nitrogen level 0.000114276352230136 0.0035532803271558 2.0532937608878 0.409090909090909 28.1 28 1 intestinal inflammation 0.00598347380856702 0.0733196605852732 2.0532937608878 0.409090909090909 28.1 28 1 abnormal sperm midpiece morphology 0.00598347380856702 0.0733196605852732 2.0532937608878 0.409090909090909 28.1 28 1 increased adenoma incidence 0.00598347380856702 0.0733196605852732 2.0532937608878 0.409090909090909 28.1 28 1 anemia 6.48402444263521e-17 2.93254741837365e-14 2.04572501084767 0.407582938388626 28.1 28 1 thymus hypoplasia 1.91185289046053e-11 3.2798165965659e-09 2.03676160500303 0.405797101449275 28.1 28 1 increased lymphocyte cell number 1.95212546589113e-06 0.000109121620143914 2.03676160500303 0.405797101449275 28.1 28 1 abnormal spleen white pulp morphology 0.000205304834855674 0.00555104105112487 2.03156578458211 0.404761904761905 28.1 28 1 abnormal placenta vasculature 3.97064611927326e-05 0.00151953572641419 2.02696948190206 0.403846153846154 28.1 28 1 enlarged spleen 8.57303613730172e-22 6.09297925472515e-19 2.02160712877533 0.402777777777778 28.1 28 1 abnormal spleen morphology 1.03170795225979e-13 2.85152614582915e-11 2.01920331530473 0.402298850574713 28.1 28 1 lethality throughout fetal growth and development, complete penetrance 1.33143723503603e-14 4.41593349620285e-12 2.00766501064585 0.4 28.1 28 1 increased monocyte cell number 2.21057431631449e-08 2.07502023088011e-06 2.00766501064585 0.4 28.1 28 1 trabecula carnea hypoplasia 0.000161045123715301 0.00463121092765099 2.00766501064585 0.4 28.1 28 1 decreased circulating thyroxine level 0.000847285520201957 0.0167271645357331 2.00766501064585 0.4 28.1 28 1 gastrointestinal hemorrhage 0.00196643600548838 0.0314427316768369 2.00766501064585 0.4 28.1 28 1 arrested T cell differentiation 0.00196643600548838 0.0314427316768369 2.00766501064585 0.4 28.1 28 1 liver hemorrhage 0.00196643600548838 0.0314427316768369 2.00766501064585 0.4 28.1 28 1 ruffled hair 0.0046166609279362 0.0607616087737635 2.00766501064585 0.4 28.1 28 1 abnormal keratinocyte physiology 0.0046166609279362 0.0607616087737635 2.00766501064585 0.4 28.1 28 1 abnormal preimplantation embryo development 0.0046166609279362 0.0607616087737635 2.00766501064585 0.4 28.1 28 1 abnormal vascular regression 0.0110180817024253 0.115314713640278 2.00766501064585 0.4 28.1 28 1 abnormal neurotransmitter secretion 0.0269697950609271 0.211224030958091 2.00766501064585 0.4 28.1 28 1 abnormal microglial cell activation 0.0269697950609271 0.211224030958091 2.00766501064585 0.4 28.1 28 1 decreased bone marrow cell number 2.15971264894946e-06 0.000117831303023811 1.99391388043595 0.397260273972603 28.1 28 1 abnormal NK cell physiology 1.92489675413891e-05 0.000811556046766193 1.97475246948772 0.39344262295082 28.1 28 1 lymphoid hyperplasia 0.00355215733959149 0.050636053766383 1.97181384974146 0.392857142857143 28.1 28 1 failure of chorioallantoic fusion 9.83920981799948e-05 0.00324172641354619 1.96829903004495 0.392156862745098 28.1 28 1 pale liver 2.98987211347938e-06 0.000154287327817613 1.96696909826789 0.391891891891892 28.1 28 1 increased bone trabecula number 0.000511389796919794 0.0115120553831492 1.9586975713618 0.390243902439024 28.1 28 1 abnormal lysosome morphology 0.00117634758085556 0.0215953107555588 1.95189653812791 0.388888888888889 28.1 28 1 thick dermal layer 0.0202703101733533 0.176858488854297 1.95189653812791 0.388888888888889 28.1 28 1 eye inflammation 0.0202703101733533 0.176858488854297 1.95189653812791 0.388888888888889 28.1 28 1 abnormal neutrophil morphology 0.0202703101733533 0.176858488854297 1.95189653812791 0.388888888888889 28.1 28 1 abnormal pregnancy 0.0202703101733533 0.176858488854297 1.95189653812791 0.388888888888889 28.1 28 1 abnormal aerobic respiration 0.0202703101733533 0.176858488854297 1.95189653812791 0.388888888888889 28.1 28 1 prenatal lethality 2.64828159536114e-05 0.00107993450302636 1.94290162320566 0.387096774193548 28.1 28 1 inner cell mass degeneration 0.00272855902902691 0.0406424585910445 1.94290162320566 0.387096774193548 28.1 28 1 abnormal CD8-positive, alpha beta T cell morphology 0.00272855902902691 0.0406424585910445 1.94290162320566 0.387096774193548 28.1 28 1 decreased double-negative T cell number 0.00272855902902691 0.0406424585910445 1.94290162320566 0.387096774193548 28.1 28 1 osteoporosis 0.000396270653336631 0.00958102692141021 1.93922188528292 0.386363636363636 28.1 28 1 increased leukocyte cell number 1.8720569540603e-10 2.66099524184286e-08 1.93843518269254 0.386206896551724 28.1 28 1 liver hypoplasia 0.000135070621297034 0.00404805024670328 1.93044712562101 0.384615384615385 28.1 28 1 abnormal nasal bone morphology 0.00640016820408294 0.077414967689569 1.93044712562101 0.384615384615385 28.1 28 1 increased susceptibility to otitis media 0.00640016820408294 0.077414967689569 1.93044712562101 0.384615384615385 28.1 28 1 abnormal erythrocyte osmotic lysis 0.00640016820408294 0.077414967689569 1.93044712562101 0.384615384615385 28.1 28 1 abnormal grip strength 0.0505104323432142 0.311773450257432 1.93044712562101 0.384615384615385 28.1 28 1 abnormal digestion 0.0505104323432142 0.311773450257432 1.93044712562101 0.384615384615385 28.1 28 1 axonal dystrophy 0.0505104323432142 0.311773450257432 1.93044712562101 0.384615384615385 28.1 28 1 increased circulating thyroxine level 0.0505104323432142 0.311773450257432 1.93044712562101 0.384615384615385 28.1 28 1 orthokeratosis 0.0505104323432142 0.311773450257432 1.93044712562101 0.384615384615385 28.1 28 1 empty decidua capsularis 0.0505104323432142 0.311773450257432 1.93044712562101 0.384615384615385 28.1 28 1 absent hypoglossal nerve 0.0505104323432142 0.311773450257432 1.93044712562101 0.384615384615385 28.1 28 1 increased T cell proliferation 6.23717795511612e-08 5.25931530961063e-06 1.92323050085233 0.383177570093458 28.1 28 1 increased cellular sensitivity to gamma-irradiation 0.000306707560139051 0.00768623564334416 1.92223245700134 0.382978723404255 28.1 28 1 abnormal eye pigmentation 0.0152515408806756 0.149439622803621 1.91206191490081 0.380952380952381 28.1 28 1 embryonic lethality at implantation, complete penetrance 0.0152515408806756 0.149439622803621 1.91206191490081 0.380952380952381 28.1 28 1 decreased susceptibility to hepatic steatosis 3.60768738068343e-05 0.00139133679991474 1.91206191490081 0.380952380952381 28.1 28 1 abnormal CD4-positive, alpha-beta T cell physiology 1.24987079424157e-05 0.000571369188728776 1.9086956087126 0.380281690140845 28.1 28 1 abnormal interventricular septum morphology 0.000237176571202684 0.00624313990335107 1.90728176011356 0.38 28.1 28 1 abnormal embryonic neuroepithelium morphology 8.12000612348684e-05 0.00284486130030613 1.90382026871589 0.379310344827586 28.1 28 1 decreased T cell number 7.49255701853389e-11 1.09650511372669e-08 1.90167027405896 0.37888198757764 28.1 28 1 decreased T cell proliferation 4.65960132268485e-10 5.94397861034798e-08 1.89914257763796 0.378378378378378 28.1 28 1 decreased IgG level 6.59160694720533e-08 5.46554076039109e-06 1.89914257763796 0.378378378378378 28.1 28 1 abnormal calcium ion homeostasis 0.00160595413060469 0.027887897156071 1.89914257763796 0.378378378378378 28.1 28 1 abnormal pancreatic islet morphology 0.00018328439056578 0.00512269574755479 1.89402359494891 0.377358490566038 28.1 28 1 embryonic lethality before implantation, complete penetrance 1.41471689731827e-08 1.40764331283168e-06 1.8872051100071 0.376 28.1 28 1 small heart 0.000415127724877627 0.00973924853348494 1.88218594748048 0.375 28.1 28 1 abnormal osteoclast morphology 0.000415127724877627 0.00973924853348494 1.88218594748048 0.375 28.1 28 1 hemolytic anemia 0.0114931195059748 0.118917862104857 1.88218594748048 0.375 28.1 28 1 decreased lymphocyte cell number 1.10285919917306e-08 1.14306760747624e-06 1.88218594748048 0.375 28.1 28 1 abnormal osteoclast physiology 4.86831317722135e-05 0.00182104195914859 1.88218594748048 0.375 28.1 28 1 increased sacral vertebrae number 4.86831317722135e-05 0.00182104195914859 1.88218594748048 0.375 28.1 28 1 abnormal heart atrium morphology 0.00371383346375493 0.052789489949088 1.88218594748048 0.375 28.1 28 1 abnormal bone marrow cell number 0.0372258441902988 0.246274700594065 1.88218594748048 0.375 28.1 28 1 abnormal mouth morphology 0.0372258441902988 0.246274700594065 1.88218594748048 0.375 28.1 28 1 disorganized yolk sac vascular plexus 0.0372258441902988 0.246274700594065 1.88218594748048 0.375 28.1 28 1 abnormal meiosis 0.0372258441902988 0.246274700594065 1.88218594748048 0.375 28.1 28 1 abnormal epicardium morphology 0.0372258441902988 0.246274700594065 1.88218594748048 0.375 28.1 28 1 large intestinal inflammation 0.0372258441902988 0.246274700594065 1.88218594748048 0.375 28.1 28 1 small pancreas 0.0372258441902988 0.246274700594065 1.88218594748048 0.375 28.1 28 1 increased cochlear outer hair cell number 0.0372258441902988 0.246274700594065 1.88218594748048 0.375 28.1 28 1 decreased circulating triiodothyronine level 0.0372258441902988 0.246274700594065 1.88218594748048 0.375 28.1 28 1 impaired somite development 0.0372258441902988 0.246274700594065 1.88218594748048 0.375 28.1 28 1 abnormal pulmonary alveolus wall morphology 0.0372258441902988 0.246274700594065 1.88218594748048 0.375 28.1 28 1 impaired hematopoiesis 0.000319579852059903 0.00794954881999009 1.8698840785427 0.372549019607843 28.1 28 1 abnormal vasculogenesis 0.00094415360400268 0.0182561016021259 1.86759535874032 0.372093023255814 28.1 28 1 abnormal liver development 0.00283049451424252 0.0420349558458404 1.86426036702829 0.371428571428571 28.1 28 1 decreased platelet aggregation 0.000245979740471639 0.00640706392066181 1.85894908393134 0.37037037037037 28.1 28 1 abnormal atrioventricular cushion morphology 0.00867517013113004 0.0938238508747216 1.85894908393134 0.37037037037037 28.1 28 1 increased brain weight 0.00867517013113004 0.0938238508747216 1.85894908393134 0.37037037037037 28.1 28 1 abnormal bone trabecula morphology 0.00867517013113004 0.0938238508747216 1.85894908393134 0.37037037037037 28.1 28 1 increased inflammatory response 1.64383582339938e-06 9.62127437813167e-05 1.84916514138433 0.368421052631579 28.1 28 1 increased bone marrow cell number 0.00215838411575185 0.0336613196735595 1.84916514138433 0.368421052631579 28.1 28 1 decreased hair follicle number 0.00215838411575185 0.0336613196735595 1.84916514138433 0.368421052631579 28.1 28 1 enlarged adrenal glands 0.027592123270485 0.211224030958091 1.84916514138433 0.368421052631579 28.1 28 1 short vibrissae 0.027592123270485 0.211224030958091 1.84916514138433 0.368421052631579 28.1 28 1 abnormal stationary movement 0.027592123270485 0.211224030958091 1.84916514138433 0.368421052631579 28.1 28 1 increased susceptibility to ischemic brain injury 0.027592123270485 0.211224030958091 1.84916514138433 0.368421052631579 28.1 28 1 abnormal blastocyst morphology 0.027592123270485 0.211224030958091 1.84916514138433 0.368421052631579 28.1 28 1 increased liver cholesterol level 0.027592123270485 0.211224030958091 1.84916514138433 0.368421052631579 28.1 28 1 impaired natural killer cell mediated cytotoxicity 0.000189311534206106 0.00523236045930764 1.84916514138433 0.368421052631579 28.1 28 1 abnormal somite development 1.34615363608973e-05 0.000603343634193371 1.84247738318765 0.367088607594937 28.1 28 1 abnormal incisor morphology 0.00014569305379267 0.00434025714142835 1.84035959309203 0.366666666666667 28.1 28 1 increased metastatic potential 0.00655868449612216 0.0778745951508538 1.84035959309203 0.366666666666667 28.1 28 1 abnormal microglial cell physiology 0.00655868449612216 0.0778745951508538 1.84035959309203 0.366666666666667 28.1 28 1 abnormal fat pad morphology 0.00655868449612216 0.0778745951508538 1.84035959309203 0.366666666666667 28.1 28 1 increased T cell number 6.21048604124841e-06 0.00029425874338296 1.82515000967804 0.363636363636364 28.1 28 1 increased coping response 0.0205475792075947 0.176858488854297 1.82515000967804 0.363636363636364 28.1 28 1 abnormal lysosome physiology 0.0205475792075947 0.176858488854297 1.82515000967804 0.363636363636364 28.1 28 1 abnormal vascular branching morphogenesis 0.0205475792075947 0.176858488854297 1.82515000967804 0.363636363636364 28.1 28 1 abnormal limb posture 0.0205475792075947 0.176858488854297 1.82515000967804 0.363636363636364 28.1 28 1 pulmonary vascular congestion 0.0205475792075947 0.176858488854297 1.82515000967804 0.363636363636364 28.1 28 1 increased mammary gland tumor incidence 0.0205475792075947 0.176858488854297 1.82515000967804 0.363636363636364 28.1 28 1 increased bone volume 0.0205475792075947 0.176858488854297 1.82515000967804 0.363636363636364 28.1 28 1 embryonic lethality before implantation, incomplete penetrance 0.0205475792075947 0.176858488854297 1.82515000967804 0.363636363636364 28.1 28 1 impaired humoral immune response 0.0205475792075947 0.176858488854297 1.82515000967804 0.363636363636364 28.1 28 1 abnormal skeleton physiology 0.00496606830365046 0.0633492046427207 1.82515000967804 0.363636363636364 28.1 28 1 increased cardiomyocyte apoptosis 0.00496606830365046 0.0633492046427207 1.82515000967804 0.363636363636364 28.1 28 1 increased osteoblast cell number 0.00496606830365046 0.0633492046427207 1.82515000967804 0.363636363636364 28.1 28 1 myeloid hyperplasia 0.00496606830365046 0.0633492046427207 1.82515000967804 0.363636363636364 28.1 28 1 decreased erythrocyte cell number 2.01062842865568e-09 2.32625033315395e-07 1.82224371985372 0.363057324840764 28.1 28 1 abnormal immune system physiology 9.70021457282168e-08 7.91124057373572e-06 1.82147027175531 0.362903225806452 28.1 28 1 increased spleen weight 3.54754863241219e-07 2.48578231637333e-05 1.82111206717876 0.36283185840708 28.1 28 1 increased grip strength 4.7979003786771e-06 0.000230702019145711 1.82013586129981 0.362637362637363 28.1 28 1 abnormal cell nucleus morphology 0.000960373678816527 0.0183763809696624 1.81544176494571 0.361702127659574 28.1 28 1 increased respiratory quotient 0.000960373678816527 0.0183763809696624 1.81544176494571 0.361702127659574 28.1 28 1 kidney inflammation 0.000734031098749414 0.0149664127716325 1.80689850958126 0.36 28.1 28 1 abnormal egg cylinder morphology 0.0153611274561214 0.149439622803621 1.80689850958126 0.36 28.1 28 1 embryonic lethality between implantation and somite formation, complete penetrance 1.97170961008159e-13 4.90462765507796e-11 1.80280123404933 0.359183673469388 28.1 28 1 thrombocytopenia 1.61961616269995e-08 1.54953661719851e-06 1.79997552678593 0.358620689655172 28.1 28 1 straub tail 0.0115212883486515 0.118917862104857 1.79255804521951 0.357142857142857 28.1 28 1 abnormal brainstem morphology 0.0115212883486515 0.118917862104857 1.79255804521951 0.357142857142857 28.1 28 1 increased aggression towards males 0.068143342675663 0.373992418451224 1.79255804521951 0.357142857142857 28.1 28 1 abnormal adrenal gland secretion 0.068143342675663 0.373992418451224 1.79255804521951 0.357142857142857 28.1 28 1 increased lactate dehydrogenase level 0.068143342675663 0.373992418451224 1.79255804521951 0.357142857142857 28.1 28 1 abnormal vascular endothelial cell migration 0.068143342675663 0.373992418451224 1.79255804521951 0.357142857142857 28.1 28 1 abnormal imprinting 0.068143342675663 0.373992418451224 1.79255804521951 0.357142857142857 28.1 28 1 increased circulating growth hormone level 0.068143342675663 0.373992418451224 1.79255804521951 0.357142857142857 28.1 28 1 pulmonary alveolar hemorrhage 0.068143342675663 0.373992418451224 1.79255804521951 0.357142857142857 28.1 28 1 small placenta 0.00165344663641764 0.0282676873408171 1.78459112057409 0.355555555555556 28.1 28 1 decreased osteoclast cell number 0.00165344663641764 0.0282676873408171 1.78459112057409 0.355555555555556 28.1 28 1 lethality at weaning, complete penetrance 0.00165344663641764 0.0282676873408171 1.78459112057409 0.355555555555556 28.1 28 1 abnormal dendritic cell physiology 1.72001330840681e-06 9.9500769875859e-05 1.78250631786314 0.355140186915888 28.1 28 1 osteopetrosis 0.00866525350302452 0.0938238508747216 1.78099315460519 0.354838709677419 28.1 28 1 abnormal capillary morphology 0.00866525350302452 0.0938238508747216 1.78099315460519 0.354838709677419 28.1 28 1 decreased thymus weight 0.00866525350302452 0.0938238508747216 1.78099315460519 0.354838709677419 28.1 28 1 abnormal T cell proliferation 0.00866525350302452 0.0938238508747216 1.78099315460519 0.354838709677419 28.1 28 1 abnormal lymph node morphology 0.00125937952452496 0.0226188199801865 1.77762006150934 0.354166666666667 28.1 28 1 abnormal lung development 2.33832152503591e-05 0.000977575595550728 1.77146912704045 0.352941176470588 28.1 28 1 decreased mean corpuscular hemoglobin 0.000147912896923506 0.00438015870353836 1.77146912704045 0.352941176470588 28.1 28 1 abnormal bone marrow cavity morphology 0.0496668045334894 0.309639539541491 1.77146912704045 0.352941176470588 28.1 28 1 abnormal glutamate-mediated receptor currents 0.0496668045334894 0.309639539541491 1.77146912704045 0.352941176470588 28.1 28 1 decreased vasoconstriction 0.0496668045334894 0.309639539541491 1.77146912704045 0.352941176470588 28.1 28 1 increased brain size 0.0496668045334894 0.309639539541491 1.77146912704045 0.352941176470588 28.1 28 1 increased trabecular bone mass 0.0496668045334894 0.309639539541491 1.77146912704045 0.352941176470588 28.1 28 1 preweaning lethality, complete penetrance 1.35360742741141e-35 6.73419695137176e-32 1.7702721884411 0.352702702702703 28.1 28 1 preweaning lethality, incomplete penetrance 4.05386746100462e-20 2.24088784649977e-17 1.76713790668094 0.352078239608802 28.1 28 1 small spleen 1.38372319133751e-05 0.000614644899723581 1.76498022913921 0.351648351648352 28.1 28 1 increased erythroid progenitor cell number 0.00493517250276941 0.0633492046427207 1.76348953637811 0.351351351351351 28.1 28 1 skin inflammation 0.00493517250276941 0.0633492046427207 1.76348953637811 0.351351351351351 28.1 28 1 decreased birth body size 1.32580924908815e-06 7.94740232729035e-05 1.76110965846127 0.350877192982456 28.1 28 1 decreased susceptibility to induced arthritis 0.000559343279208103 0.0123677013958236 1.76110965846127 0.350877192982456 28.1 28 1 abnormal eating behavior 0.000427395362087846 0.00975363268984878 1.75670688431512 0.35 28.1 28 1 absent mesoderm 0.000427395362087846 0.00975363268984878 1.75670688431512 0.35 28.1 28 1 increased erythrocyte cell number 0.000427395362087846 0.00975363268984878 1.75670688431512 0.35 28.1 28 1 decreased myocardial infarction size 0.036516607191748 0.246274700594065 1.75670688431512 0.35 28.1 28 1 abnormal physiological neovascularization 0.036516607191748 0.246274700594065 1.75670688431512 0.35 28.1 28 1 abnormal sperm mitochondrial sheath morphology 0.036516607191748 0.246274700594065 1.75670688431512 0.35 28.1 28 1 absent ductus venosus valve 0.036516607191748 0.246274700594065 1.75670688431512 0.35 28.1 28 1 increased bone mineral content 2.87977705937594e-06 0.000150809377583108 1.74979977992069 0.348623853211009 28.1 28 1 embryonic lethality between implantation and placentation, complete penetrance 0.00214918284095403 0.0336613196735595 1.74579566143117 0.347826086956522 28.1 28 1 pancreas inflammation 0.0270256318857393 0.211224030958091 1.74579566143117 0.347826086956522 28.1 28 1 decreased circulating creatinine level 0.00163349430411153 0.0282174797324822 1.74134210107038 0.346938775510204 28.1 28 1 decreased circulating glycerol level 0.0201051647072006 0.176858488854297 1.73740241305891 0.346153846153846 28.1 28 1 abnormal embryo turning 0.000946748585597687 0.0182561016021259 1.73389250919414 0.345454545454545 28.1 28 1 decreased embryo size 7.92507584716692e-22 6.09297925472515e-19 1.73255610228329 0.345188284518828 28.1 28 1 polychromatophilia 0.01501940850607 0.149439622803621 1.73074569883263 0.344827586206897 28.1 28 1 blood in lymph vessels 0.01501940850607 0.149439622803621 1.73074569883263 0.344827586206897 28.1 28 1 increased neutrophil cell number 1.26531887762328e-07 1.01531635744771e-05 1.73074569883263 0.344827586206897 28.1 28 1 increased osteoclast cell number 0.000550766773208529 0.0122324316817519 1.72790841080175 0.344262295081967 28.1 28 1 abnormal male meiosis 0.000550766773208529 0.0122324316817519 1.72790841080175 0.344262295081967 28.1 28 1 decreased caudal vertebrae number 0.000420583520366011 0.00973924853348494 1.72533711852378 0.34375 28.1 28 1 decreased eosinophil cell number 0.000420583520366011 0.00973924853348494 1.72533711852378 0.34375 28.1 28 1 scoliosis 0.0112588544759753 0.116936954108512 1.72533711852378 0.34375 28.1 28 1 abnormal lumbar vertebrae morphology 0.0112588544759753 0.116936954108512 1.72533711852378 0.34375 28.1 28 1 decreased susceptibility to parasitic infection 0.0112588544759753 0.116936954108512 1.72533711852378 0.34375 28.1 28 1 decreased bone volume 0.00846431548749504 0.0938238508747216 1.72085572341073 0.342857142857143 28.1 28 1 decreased percent body fat/body weight 0.000188039821827764 0.00522624644465434 1.71889127623788 0.342465753424658 28.1 28 1 abnormal placenta labyrinth morphology 0.000110260126321814 0.00347179828133561 1.71540997745057 0.341772151898734 28.1 28 1 sparse hair 8.44929161017466e-05 0.00290395126318296 1.71386037494158 0.341463414634146 28.1 28 1 abnormal mammary gland development 0.0048178122098638 0.062581242151625 1.71386037494158 0.341463414634146 28.1 28 1 scaly skin 0.0048178122098638 0.062581242151625 1.71386037494158 0.341463414634146 28.1 28 1 abnormal liver physiology 1.72519369833404e-05 0.000739899883552748 1.70651525904897 0.34 28.1 28 1 pericardial effusion 0.000703883552153223 0.014410784658281 1.70003892030495 0.338709677419355 28.1 28 1 pericardial edema 0.000410068565079274 0.00971471957747328 1.69765791341377 0.338235294117647 28.1 28 1 abnormal T cell activation 0.00023958144977902 0.00627325111921381 1.69566301574818 0.337837837837838 28.1 28 1 increased oxygen consumption 8.23459682884548e-05 0.00286483351213331 1.69250829385842 0.337209302325581 28.1 28 1 pallor 2.50458616020749e-08 2.22505645482719e-06 1.69217479468721 0.337142857142857 28.1 28 1 decreased leukocyte cell number 9.36352329851812e-07 5.89664916583895e-05 1.68526624981221 0.335766423357664 28.1 28 1 prenatal lethality, incomplete penetrance 3.61578619069174e-13 8.17660740849609e-11 1.68406111090359 0.335526315789474 28.1 28 1 lethality throughout fetal growth and development, incomplete penetrance 2.4375508076065e-08 2.20487550324406e-06 1.68240084690993 0.335195530726257 28.1 28 1 decreased cell proliferation 1.44953696747916e-08 1.41400910062918e-06 1.6820977116222 0.335135135135135 28.1 28 1 abnormal hepatocyte morphology 1.25184405168717e-05 0.000571369188728776 1.67305417553821 0.333333333333333 28.1 28 1 abnormal inflammatory response 0.00039672191875588 0.00958102692141021 1.67305417553821 0.333333333333333 28.1 28 1 gliosis 0.000892432845082183 0.017411189820721 1.67305417553821 0.333333333333333 28.1 28 1 impaired limb coordination 0.00202396881040504 0.0320676586998888 1.67305417553821 0.333333333333333 28.1 28 1 abnormal osteoblast physiology 0.00202396881040504 0.0320676586998888 1.67305417553821 0.333333333333333 28.1 28 1 impaired wound healing 0.0108137496668598 0.113498743866303 1.67305417553821 0.333333333333333 28.1 28 1 salivary gland inflammation 0.0192497705110438 0.170633563828673 1.67305417553821 0.333333333333333 28.1 28 1 rectal prolapse 0.025820161995236 0.211224030958091 1.67305417553821 0.333333333333333 28.1 28 1 abnormal trigeminal nerve morphology 0.025820161995236 0.211224030958091 1.67305417553821 0.333333333333333 28.1 28 1 abnormal tumor morphology 0.0347918880756216 0.243395936883656 1.67305417553821 0.333333333333333 28.1 28 1 abnormal salivary gland morphology 0.0471491403472842 0.299145980379318 1.67305417553821 0.333333333333333 28.1 28 1 increased incidence of induced tumors 0.0471491403472842 0.299145980379318 1.67305417553821 0.333333333333333 28.1 28 1 left pulmonary isomerism 0.0471491403472842 0.299145980379318 1.67305417553821 0.333333333333333 28.1 28 1 abnormal embryonic/fetal subventricular zone morphology 0.0471491403472842 0.299145980379318 1.67305417553821 0.333333333333333 28.1 28 1 increased keratinocyte proliferation 0.0471491403472842 0.299145980379318 1.67305417553821 0.333333333333333 28.1 28 1 increased muscle cell glucose uptake 0.0471491403472842 0.299145980379318 1.67305417553821 0.333333333333333 28.1 28 1 underdeveloped hair follicles 0.0643650517135578 0.361417756518002 1.67305417553821 0.333333333333333 28.1 28 1 abnormal thymus medulla morphology 0.0643650517135578 0.361417756518002 1.67305417553821 0.333333333333333 28.1 28 1 abnormal bile duct morphology 0.0643650517135578 0.361417756518002 1.67305417553821 0.333333333333333 28.1 28 1 abnormal white adipose tissue morphology 0.0643650517135578 0.361417756518002 1.67305417553821 0.333333333333333 28.1 28 1 decreased cellular sensitivity to gamma-irradiation 0.0643650517135578 0.361417756518002 1.67305417553821 0.333333333333333 28.1 28 1 increased susceptibility to autoimmune disorder 0.0643650517135578 0.361417756518002 1.67305417553821 0.333333333333333 28.1 28 1 decreased lactate dehydrogenase level 0.0643650517135578 0.361417756518002 1.67305417553821 0.333333333333333 28.1 28 1 decreased tumor latency 0.0643650517135578 0.361417756518002 1.67305417553821 0.333333333333333 28.1 28 1 atrioventricular block 0.0643650517135578 0.361417756518002 1.67305417553821 0.333333333333333 28.1 28 1 abnormal macrophage chemotaxis 0.0643650517135578 0.361417756518002 1.67305417553821 0.333333333333333 28.1 28 1 primary atelectasis 0.0643650517135578 0.361417756518002 1.67305417553821 0.333333333333333 28.1 28 1 abnormal hypoglossal nerve topology 0.0643650517135578 0.361417756518002 1.67305417553821 0.333333333333333 28.1 28 1 increased adipocyte glucose uptake 0.0643650517135578 0.361417756518002 1.67305417553821 0.333333333333333 28.1 28 1 abnormal epidermis stratum spinosum morphology 0.0887301164830309 0.436629406036676 1.67305417553821 0.333333333333333 28.1 28 1 audiogenic seizures 0.0887301164830309 0.436629406036676 1.67305417553821 0.333333333333333 28.1 28 1 increased airway responsiveness 0.0887301164830309 0.436629406036676 1.67305417553821 0.333333333333333 28.1 28 1 abnormal bronchus morphology 0.0887301164830309 0.436629406036676 1.67305417553821 0.333333333333333 28.1 28 1 abnormal placenta size 0.0887301164830309 0.436629406036676 1.67305417553821 0.333333333333333 28.1 28 1 bicuspid aortic valve 0.0887301164830309 0.436629406036676 1.67305417553821 0.333333333333333 28.1 28 1 abnormal coronary vessel morphology 0.0887301164830309 0.436629406036676 1.67305417553821 0.333333333333333 28.1 28 1 decreased trabecular bone mass 0.0887301164830309 0.436629406036676 1.67305417553821 0.333333333333333 28.1 28 1 abnormal branching involved in lung morphogenesis 0.0887301164830309 0.436629406036676 1.67305417553821 0.333333333333333 28.1 28 1 decreased circulating serum albumin level 3.59944186686199e-05 0.00139133679991474 1.67305417553821 0.333333333333333 28.1 28 1 abnormal metabolism 0.00464135748386262 0.060886455527582 1.67305417553821 0.333333333333333 28.1 28 1 abnormal leukocyte adhesion 0.00813927130479442 0.0924494857108499 1.67305417553821 0.333333333333333 28.1 28 1 increased autoantibody level 0.00813927130479442 0.0924494857108499 1.67305417553821 0.333333333333333 28.1 28 1 failure of heart looping 0.00813927130479442 0.0924494857108499 1.67305417553821 0.333333333333333 28.1 28 1 abnormal aorta morphology 0.0144052475621377 0.145073090327196 1.67305417553821 0.333333333333333 28.1 28 1 abnormal QRS complex 0.0144052475621377 0.145073090327196 1.67305417553821 0.333333333333333 28.1 28 1 embryonic lethality during organogenesis, complete penetrance 2.90855329527367e-22 2.89401052879731e-19 1.66707898205414 0.332142857142857 28.1 28 1 hemorrhage 3.60270569117059e-10 4.71670021409833e-08 1.66593479606783 0.331914893617021 28.1 28 1 abnormal cytokine secretion 4.01242774799127e-07 2.73449699263788e-05 1.66219018738536 0.331168831168831 28.1 28 1 lung inflammation 1.92447895639794e-06 0.000108798668273633 1.66075230660043 0.330882352941176 28.1 28 1 abnormal coat/hair pigmentation 1.57246403688074e-05 0.000692301644555902 1.65811619182804 0.330357142857143 28.1 28 1 hunched posture 0.0002915712958486 0.00740085304513666 1.65187627458203 0.329113924050633 28.1 28 1 abnormal response to infection 0.0002915712958486 0.00740085304513666 1.65187627458203 0.329113924050633 28.1 28 1 internal hemorrhage 0.000856152510472194 0.0167691288960597 1.64808321769435 0.328358208955224 28.1 28 1 decreased white adipose tissue amount 0.000856152510472194 0.0167691288960597 1.64808321769435 0.328358208955224 28.1 28 1 dermatitis 0.00193692382564223 0.0314427316768369 1.644208413891 0.327586206896552 28.1 28 1 thrombocytosis 0.00193692382564223 0.0314427316768369 1.644208413891 0.327586206896552 28.1 28 1 perinatal lethality, incomplete penetrance 1.98215311617735e-09 2.32625033315395e-07 1.6434425972101 0.327433628318584 28.1 28 1 abnormal contextual conditioning behavior 0.00254802189274374 0.038297307904532 1.64263500871024 0.327272727272727 28.1 28 1 decreased circulating total protein level 0.00254802189274374 0.038297307904532 1.64263500871024 0.327272727272727 28.1 28 1 abnormal leukocyte migration 0.0033560563733854 0.0483953056741807 1.64088005677786 0.326923076923077 28.1 28 1 kinked neural tube 0.0033560563733854 0.0483953056741807 1.64088005677786 0.326923076923077 28.1 28 1 abnormal respiratory system physiology 0.0044264327996788 0.0607616087737635 1.63891021277212 0.326530612244898 28.1 28 1 abnormal bone structure 3.43704832799646e-08 2.9998799003127e-06 1.63837947759959 0.326424870466321 28.1 28 1 abnormal locomotor behavior 0.00012533167287373 0.00382132759405558 1.63668343259172 0.326086956521739 28.1 28 1 atrial septal defect 0.00584724844010875 0.0723633357948782 1.63668343259172 0.326086956521739 28.1 28 1 weight loss 1.63389648245555e-07 1.25055923080252e-05 1.63481293724019 0.325714285714286 28.1 28 1 edema 2.11923316319272e-07 1.59745227073997e-05 1.63414593889778 0.325581395348837 28.1 28 1 abnormal homeostasis 0.0077376877217165 0.0890983722033736 1.63414593889778 0.325581395348837 28.1 28 1 impaired macrophage phagocytosis 0.0077376877217165 0.0890983722033736 1.63414593889778 0.325581395348837 28.1 28 1 decreased oxygen consumption 0.0077376877217165 0.0890983722033736 1.63414593889778 0.325581395348837 28.1 28 1 abnormal double-strand DNA break repair 0.0077376877217165 0.0890983722033736 1.63414593889778 0.325581395348837 28.1 28 1 abnormal pancreatic beta cell morphology 0.0102598313464847 0.108370830039833 1.63122782114975 0.325 28.1 28 1 small seminiferous tubules 0.000623422570046123 0.0134265250475301 1.62783649511826 0.324324324324324 28.1 28 1 prenatal lethality, complete penetrance 7.49370328979042e-11 1.09650511372669e-08 1.62490873163783 0.323741007194245 28.1 28 1 abnormal oocyte morphology 0.0181703695710901 0.163467610517493 1.62384669978708 0.323529411764706 28.1 28 1 decreased cytotoxic T cell cytolysis 0.0181703695710901 0.163467610517493 1.62384669978708 0.323529411764706 28.1 28 1 increased susceptibility to viral infection induced morbidity/mortality 0.0181703695710901 0.163467610517493 1.62384669978708 0.323529411764706 28.1 28 1 decreased bone mineral density 2.1075001910906e-10 2.91244818074325e-08 1.62273675672503 0.323308270676692 28.1 28 1 embryonic growth arrest 3.79264094092875e-09 4.19297526247123e-07 1.62191278152612 0.323144104803493 28.1 28 1 embryonic lethality, complete penetrance 3.98674169365161e-12 7.62847689458336e-10 1.62060733617964 0.322884012539185 28.1 28 1 increased eosinophil cell number 0.00184075252600659 0.0304243980627336 1.61908468600472 0.32258064516129 28.1 28 1 abnormal eyelid morphology 0.0242900167053387 0.201069605838702 1.61908468600472 0.32258064516129 28.1 28 1 small cranium 0.0242900167053387 0.201069605838702 1.61908468600472 0.32258064516129 28.1 28 1 abnormal mitochondrial ATP synthesis coupled electron transport 0.0242900167053387 0.201069605838702 1.61908468600472 0.32258064516129 28.1 28 1 decreased circulating cholesterol level 1.49390992600044e-07 1.16128154403941e-05 1.61819994027466 0.322404371584699 28.1 28 1 oxidative stress 0.000203365779680993 0.00552865985744777 1.61728570302027 0.322222222222222 28.1 28 1 increased susceptibility to parasitic infection 0.000203365779680993 0.00552865985744777 1.61728570302027 0.322222222222222 28.1 28 1 increased insulin sensitivity 3.55732013871133e-06 0.000178764320101908 1.61455577779212 0.321678321678322 28.1 28 1 rib bifurcation 0.0325933126699338 0.233311842493411 1.61330224069756 0.321428571428571 28.1 28 1 abnormal ovulation 0.0325933126699338 0.233311842493411 1.61330224069756 0.321428571428571 28.1 28 1 failure of blastocyst to hatch from the zona pellucida 0.0325933126699338 0.233311842493411 1.61330224069756 0.321428571428571 28.1 28 1 corneal vascularization 0.0325933126699338 0.233311842493411 1.61330224069756 0.321428571428571 28.1 28 1 subcutaneous edema 0.0325933126699338 0.233311842493411 1.61330224069756 0.321428571428571 28.1 28 1 abnormal placenta development 0.00418837819607418 0.0583674552534147 1.60992005570658 0.320754716981132 28.1 28 1 increased cellular sensitivity to ionizing radiation 0.0439357754259745 0.284610003573207 1.60613200851668 0.32 28.1 28 1 abnormal cochlear outer hair cell morphology 0.0439357754259745 0.284610003573207 1.60613200851668 0.32 28.1 28 1 kyphosis 2.60777736173188e-06 0.000139502068544259 1.60613200851668 0.32 28.1 28 1 postnatal lethality 8.75556599196329e-07 5.59865638528491e-05 1.60250369825648 0.319277108433735 28.1 28 1 abnormal T-helper 1 physiology 0.00729310156984058 0.0857758399762574 1.60186038083445 0.319148936170213 28.1 28 1 microcephaly 0.0013269822230121 0.02357763056959 1.60031268964524 0.318840579710145 28.1 28 1 limb grasping 2.9463447232527e-07 2.0940092854546e-05 1.59951333265741 0.318681318681319 28.1 28 1 decreased macrophage cell number 0.00964742796453976 0.102995609707265 1.59700625846829 0.318181818181818 28.1 28 1 abnormal abdominal fat pad morphology 0.0595632022124726 0.354458051443841 1.59700625846829 0.318181818181818 28.1 28 1 testis hypoplasia 0.0595632022124726 0.354458051443841 1.59700625846829 0.318181818181818 28.1 28 1 abnormal cerebral cortex pyramidal cell morphology 0.0595632022124726 0.354458051443841 1.59700625846829 0.318181818181818 28.1 28 1 rough coat 0.0595632022124726 0.354458051443841 1.59700625846829 0.318181818181818 28.1 28 1 decreased total body fat amount 6.41668414672199e-12 1.18233346777563e-09 1.59290786772799 0.317365269461078 28.1 28 1 liver fibrosis 0.0127864830884873 0.129557542495366 1.59144177673146 0.317073170731707 28.1 28 1 palatal shelves fail to meet at midline 0.0127864830884873 0.129557542495366 1.59144177673146 0.317073170731707 28.1 28 1 irregular coat pigmentation 0.0813371725334372 0.406277543527962 1.58499869261514 0.315789473684211 28.1 28 1 flaky skin 0.0813371725334372 0.406277543527962 1.58499869261514 0.315789473684211 28.1 28 1 altered susceptibility to infection 0.0813371725334372 0.406277543527962 1.58499869261514 0.315789473684211 28.1 28 1 delayed sexual maturation 0.0813371725334372 0.406277543527962 1.58499869261514 0.315789473684211 28.1 28 1 abnormal optic vesicle formation 0.0813371725334372 0.406277543527962 1.58499869261514 0.315789473684211 28.1 28 1 decreased eye pigmentation 0.0813371725334372 0.406277543527962 1.58499869261514 0.315789473684211 28.1 28 1 decreased liver glycogen level 0.0813371725334372 0.406277543527962 1.58499869261514 0.315789473684211 28.1 28 1 abnormal cell morphology 6.00397534555799e-05 0.00221257609956674 1.58499869261514 0.315789473684211 28.1 28 1 increased hepatocellular carcinoma incidence 0.00393847568124962 0.0558231239721278 1.58499869261514 0.315789473684211 28.1 28 1 decreased hematocrit 6.63039648572997e-06 0.00031119077845761 1.58137997413885 0.315068493150685 28.1 28 1 increased cell proliferation 0.00518283656246267 0.0649239138075641 1.58010672134164 0.314814814814815 28.1 28 1 abnormal apoptosis 0.00518283656246267 0.0649239138075641 1.58010672134164 0.314814814814815 28.1 28 1 decreased tumor growth/size 0.00518283656246267 0.0649239138075641 1.58010672134164 0.314814814814815 28.1 28 1 axon degeneration 0.00518283656246267 0.0649239138075641 1.58010672134164 0.314814814814815 28.1 28 1 anophthalmia 0.000403826207174586 0.00963970445075974 1.5790623679237 0.314606741573034 28.1 28 1 increased circulating serum albumin level 0.0226189776927379 0.192029716760019 1.57745107979317 0.314285714285714 28.1 28 1 decreased glycogen level 0.0226189776927379 0.192029716760019 1.57745107979317 0.314285714285714 28.1 28 1 increased red blood cell distribution width 0.0226189776927379 0.192029716760019 1.57745107979317 0.314285714285714 28.1 28 1 abnormal bone mineralization 4.35799207821486e-05 0.00165503897626862 1.57626591744922 0.31404958677686 28.1 28 1 premature death 2.50341004413811e-27 4.1514883231957e-24 1.57395340555859 0.313588850174216 28.1 28 1 increased total body fat amount 1.87717281500784e-05 0.000798199551680684 1.57317034416279 0.313432835820896 28.1 28 1 pale yolk sac 0.000687381520849086 0.0141897222664905 1.57226777942145 0.313253012048193 28.1 28 1 abnormal glucose homeostasis 7.02229695250589e-07 4.596832544568e-05 1.57193551657711 0.313186813186813 28.1 28 1 increased mean corpuscular hemoglobin 0.000223734976993627 0.00601665681374753 1.57165695277832 0.313131313131313 28.1 28 1 abnormal spongiotrophoblast layer morphology 0.0302132722641403 0.220935101873084 1.56848828956707 0.3125 28.1 28 1 pancreatic islet hyperplasia 0.0302132722641403 0.220935101873084 1.56848828956707 0.3125 28.1 28 1 vasculature congestion 0.112141149343364 0.511367752505256 1.56848828956707 0.3125 28.1 28 1 delayed hair appearance 0.112141149343364 0.511367752505256 1.56848828956707 0.3125 28.1 28 1 disorganized retinal layers 0.112141149343364 0.511367752505256 1.56848828956707 0.3125 28.1 28 1 poor circulation 0.112141149343364 0.511367752505256 1.56848828956707 0.3125 28.1 28 1 abnormal olfaction 0.112141149343364 0.511367752505256 1.56848828956707 0.3125 28.1 28 1 white spotting 0.112141149343364 0.511367752505256 1.56848828956707 0.3125 28.1 28 1 abnormal pulmonary elastic fiber morphology 0.112141149343364 0.511367752505256 1.56848828956707 0.3125 28.1 28 1 increased pancreatic beta cell number 0.112141149343364 0.511367752505256 1.56848828956707 0.3125 28.1 28 1 decreased circulating prolactin level 0.112141149343364 0.511367752505256 1.56848828956707 0.3125 28.1 28 1 blepharitis 0.112141149343364 0.511367752505256 1.56848828956707 0.3125 28.1 28 1 impaired behavioral response to addictive substance 0.112141149343364 0.511367752505256 1.56848828956707 0.3125 28.1 28 1 increased heart left ventricle size 0.112141149343364 0.511367752505256 1.56848828956707 0.3125 28.1 28 1 dilated respiratory conducting tubes 0.112141149343364 0.511367752505256 1.56848828956707 0.3125 28.1 28 1 decreased midbrain size 0.112141149343364 0.511367752505256 1.56848828956707 0.3125 28.1 28 1 abnormal cell migration 0.0119082339880714 0.122403851426974 1.56151723050233 0.311111111111111 28.1 28 1 impaired glucose tolerance 1.34285667738257e-08 1.36341060611802e-06 1.55836901027954 0.310483870967742 28.1 28 1 abnormal retinal pigmentation 0.000644340790844716 0.0137734583495592 1.55767112894936 0.310344827586207 28.1 28 1 abnormal spermiogenesis 0.00483917401627295 0.0626950279452029 1.55767112894936 0.310344827586207 28.1 28 1 abnormal spinal nerve morphology 0.0405015695436726 0.264814805118901 1.55767112894936 0.310344827586207 28.1 28 1 abnormal CD8-positive, alpha-beta T cell physiology 0.0405015695436726 0.264814805118901 1.55767112894936 0.310344827586207 28.1 28 1 abnormal muscle morphology 0.0157658332329384 0.149439622803621 1.55355030585691 0.30952380952381 28.1 28 1 abnormal head morphology 0.00636156944102118 0.077414967689569 1.55137750822634 0.309090909090909 28.1 28 1 ventricular septal defect 2.78698167109204e-05 0.00112725478160023 1.5500354861604 0.308823529411765 28.1 28 1 increased exploration in new environment 0.00109594634611456 0.0205083227603463 1.54912423660945 0.308641975308642 28.1 28 1 abnormal skeleton development 0.00109594634611456 0.0205083227603463 1.54912423660945 0.308641975308642 28.1 28 1 increased neuron apoptosis 0.00109594634611456 0.0205083227603463 1.54912423660945 0.308641975308642 28.1 28 1 abnormal skin condition 0.00837249850472249 0.0938238508747216 1.54435770049681 0.307692307692308 28.1 28 1 eyelids open at birth 0.00837249850472249 0.0938238508747216 1.54435770049681 0.307692307692308 28.1 28 1 ventricular hypoplasia 0.0545271579676519 0.329250746779592 1.54435770049681 0.307692307692308 28.1 28 1 thick skin 0.0545271579676519 0.329250746779592 1.54435770049681 0.307692307692308 28.1 28 1 abnormal nerve conduction 0.0545271579676519 0.329250746779592 1.54435770049681 0.307692307692308 28.1 28 1 increased thymocyte apoptosis 0.0545271579676519 0.329250746779592 1.54435770049681 0.307692307692308 28.1 28 1 abnormal response to injury 0.0209157963781723 0.179098256422387 1.54435770049681 0.307692307692308 28.1 28 1 decreased trabecular bone volume 0.0209157963781723 0.179098256422387 1.54435770049681 0.307692307692308 28.1 28 1 increased sarcoma incidence 0.0110331263704065 0.115314713640278 1.53647832447386 0.306122448979592 28.1 28 1 abnormal epidermis stratum granulosum morphology 0.0278132780241243 0.212551548648262 1.53363299424336 0.305555555555556 28.1 28 1 hyperkeratosis 0.00318859976811504 0.0470720588913125 1.52757120375228 0.304347826086957 28.1 28 1 abnormal circulating insulin level 0.0737983892304186 0.376175191005464 1.52757120375228 0.304347826086957 28.1 28 1 hypotension 0.0737983892304186 0.376175191005464 1.52757120375228 0.304347826086957 28.1 28 1 abnormal sacral vertebrae morphology 0.0737983892304186 0.376175191005464 1.52757120375228 0.304347826086957 28.1 28 1 abnormal Wolffian duct morphology 0.0737983892304186 0.376175191005464 1.52757120375228 0.304347826086957 28.1 28 1 abnormal vertebral artery topology 0.0737983892304186 0.376175191005464 1.52757120375228 0.304347826086957 28.1 28 1 embryonic lethality during organogenesis, incomplete penetrance 1.41960620568994e-07 1.12103823385832e-05 1.52757120375228 0.304347826086957 28.1 28 1 abnormal vitelline vasculature morphology 0.000171400130818542 0.00484497528876275 1.52757120375228 0.304347826086957 28.1 28 1 abnormal extraembryonic tissue morphology 0.000402194457330641 0.00963970445075974 1.52543174828484 0.303921568627451 28.1 28 1 belly spot 0.0370863264824022 0.246274700594065 1.52095834139837 0.303030303030303 28.1 28 1 abnormal ovarian folliculogenesis 0.0370863264824022 0.246274700594065 1.52095834139837 0.303030303030303 28.1 28 1 abnormal epidermis stratum basale morphology 0.0370863264824022 0.246274700594065 1.52095834139837 0.303030303030303 28.1 28 1 decreased brown adipose tissue amount 0.0370863264824022 0.246274700594065 1.52095834139837 0.303030303030303 28.1 28 1 decreased systemic arterial blood pressure 0.0370863264824022 0.246274700594065 1.52095834139837 0.303030303030303 28.1 28 1 abnormal trabecular bone morphology 0.00015954203304843 0.00461466054892989 1.51840210889182 0.302521008403361 28.1 28 1 abnormal left-right axis patterning 0.0192446962878013 0.170633563828673 1.51742122897651 0.302325581395349 28.1 28 1 delayed endochondral bone ossification 0.0192446962878013 0.170633563828673 1.51742122897651 0.302325581395349 28.1 28 1 ataxia 1.16213840424536e-06 7.22704820140085e-05 1.51568769368065 0.301980198019802 28.1 28 1 abnormal neural tube closure 0.00160880934347585 0.027887897156071 1.51179594175139 0.301204819277108 28.1 28 1 intracranial hemorrhage 0.00714725582149579 0.0842597102178709 1.50574875798439 0.3 28.1 28 1 abnormal synaptic transmission 0.0496094834147991 0.309639539541491 1.50574875798439 0.3 28.1 28 1 abnormal lipid homeostasis 0.000106405043126479 0.00340174069324743 1.50574875798439 0.3 28.1 28 1 decreased insulin secretion 0.00114517666386023 0.0211793825379356 1.50574875798439 0.3 28.1 28 1 abnormal skin pigmentation 0.0254826385346098 0.21024233285188 1.50574875798439 0.3 28.1 28 1 increased urine glucose level 0.100545986251304 0.471013447834498 1.50574875798439 0.3 28.1 28 1 spleen atrophy 0.100545986251304 0.471013447834498 1.50574875798439 0.3 28.1 28 1 abnormal induced retinal neovascularization 0.100545986251304 0.471013447834498 1.50574875798439 0.3 28.1 28 1 decreased bone trabecula number 0.0176428057815627 0.159877884814708 1.49506968877882 0.297872340425532 28.1 28 1 increased white adipose tissue amount 0.0338115828127209 0.239960947921949 1.4921834538584 0.297297297297297 28.1 28 1 malocclusion 0.0338115828127209 0.239960947921949 1.4921834538584 0.297297297297297 28.1 28 1 abnormal branching of the mammary ductal tree 0.0338115828127209 0.239960947921949 1.4921834538584 0.297297297297297 28.1 28 1 decreased width of hypertrophic chondrocyte zone 0.0338115828127209 0.239960947921949 1.4921834538584 0.297297297297297 28.1 28 1 abnormal chromosome morphology 0.0338115828127209 0.239960947921949 1.4921834538584 0.297297297297297 28.1 28 1 decreased circulating HDL cholesterol level 0.000164663629188922 0.00468115174408506 1.49006387508872 0.296875 28.1 28 1 abnormal maxilla morphology 0.0122866946757679 0.126033620643187 1.48715926714507 0.296296296296296 28.1 28 1 abnormal heart valve morphology 0.0666143141665639 0.371948611648323 1.48715926714507 0.296296296296296 28.1 28 1 abnormal fetal cardiomyocyte proliferation 0.0666143141665639 0.371948611648323 1.48715926714507 0.296296296296296 28.1 28 1 abnormal eye muscle morphology 0.0666143141665639 0.371948611648323 1.48715926714507 0.296296296296296 28.1 28 1 decreased circulating fructosamine level 0.0666143141665639 0.371948611648323 1.48715926714507 0.296296296296296 28.1 28 1 thick interventricular septum 0.0666143141665639 0.371948611648323 1.48715926714507 0.296296296296296 28.1 28 1 abnormal neural tube morphology 2.62529591260027e-05 0.00107940885662697 1.48715926714507 0.296296296296296 28.1 28 1 postnatal growth retardation 6.51138837884339e-16 2.69951309872882e-13 1.48442551849223 0.295751633986928 28.1 28 1 azoospermia 3.38163466057653e-05 0.00133316204692221 1.48365181604332 0.29559748427673 28.1 28 1 hyperglycemia 0.00178348895855725 0.0295915360590207 1.48293438286341 0.295454545454545 28.1 28 1 muscular atrophy 0.0232693571975562 0.19554907442203 1.48293438286341 0.295454545454545 28.1 28 1 abnormal maternal nurturing 0.00859660411214097 0.0938238508747216 1.48106435211579 0.295081967213115 28.1 28 1 increased double-negative T cell number 0.00859660411214097 0.0938238508747216 1.48106435211579 0.295081967213115 28.1 28 1 abnormal cornea morphology 0.00327051580067841 0.0478553414952208 1.48000946297611 0.294871794871795 28.1 28 1 increased urine protein level 0.00327051580067841 0.0478553414952208 1.48000946297611 0.294871794871795 28.1 28 1 decreased circulating alanine transaminase level 0.00603763789145789 0.0738015933906708 1.47622427253371 0.294117647058824 28.1 28 1 increased lung adenocarcinoma incidence 0.0161304678282502 0.149439622803621 1.47622427253371 0.294117647058824 28.1 28 1 abnormal gluconeogenesis 0.0161304678282502 0.149439622803621 1.47622427253371 0.294117647058824 28.1 28 1 small lung 0.0161304678282502 0.149439622803621 1.47622427253371 0.294117647058824 28.1 28 1 abnormal trophoblast layer morphology 0.0161304678282502 0.149439622803621 1.47622427253371 0.294117647058824 28.1 28 1 enlarged liver sinusoidal spaces 0.0449679751954489 0.289412259504991 1.47622427253371 0.294117647058824 28.1 28 1 lung hemorrhage 0.0449679751954489 0.289412259504991 1.47622427253371 0.294117647058824 28.1 28 1 thin skin 0.0449679751954489 0.289412259504991 1.47622427253371 0.294117647058824 28.1 28 1 abnormal brown adipose tissue morphology 0.0449679751954489 0.289412259504991 1.47622427253371 0.294117647058824 28.1 28 1 abnormal vagus nerve morphology 0.138172126347478 0.556503241878489 1.47622427253371 0.294117647058824 28.1 28 1 hyperlipidemia 0.138172126347478 0.556503241878489 1.47622427253371 0.294117647058824 28.1 28 1 absence seizures 0.138172126347478 0.556503241878489 1.47622427253371 0.294117647058824 28.1 28 1 abnormal involuntary movement 0.138172126347478 0.556503241878489 1.47622427253371 0.294117647058824 28.1 28 1 abnormal ectoplacental cone morphology 0.138172126347478 0.556503241878489 1.47622427253371 0.294117647058824 28.1 28 1 abnormal melanosome morphology 0.138172126347478 0.556503241878489 1.47622427253371 0.294117647058824 28.1 28 1 pancytopenia 0.138172126347478 0.556503241878489 1.47622427253371 0.294117647058824 28.1 28 1 abnormal circulating chemokine level 0.138172126347478 0.556503241878489 1.47622427253371 0.294117647058824 28.1 28 1 abnormal survival 0.138172126347478 0.556503241878489 1.47622427253371 0.294117647058824 28.1 28 1 abnormal neuron morphology 0.00116632756076838 0.0214906652400841 1.47025973001842 0.292929292929293 28.1 28 1 abnormal developmental patterning 0.0030049091077908 0.0444923297954144 1.46902317852135 0.292682926829268 28.1 28 1 thick ventricular wall 0.0307362200985226 0.222904803192639 1.46902317852135 0.292682926829268 28.1 28 1 abnormal cholesterol homeostasis 0.0307362200985226 0.222904803192639 1.46902317852135 0.292682926829268 28.1 28 1 abnormal embryo size 0.000591208344291631 0.0129002697932055 1.46577312724144 0.292035398230089 28.1 28 1 overriding aortic valve 0.021197214980786 0.180885325093328 1.46392240359593 0.291666666666667 28.1 28 1 vertebral transformation 0.021197214980786 0.180885325093328 1.46392240359593 0.291666666666667 28.1 28 1 curly vibrissae 0.0898598897059232 0.440446257425584 1.46392240359593 0.291666666666667 28.1 28 1 blindness 0.0898598897059232 0.440446257425584 1.46392240359593 0.291666666666667 28.1 28 1 abnormal lung saccule morphology 0.0898598897059232 0.440446257425584 1.46392240359593 0.291666666666667 28.1 28 1 decreased circulating calcium level 0.0147175152848949 0.147620238996678 1.46012000774243 0.290909090909091 28.1 28 1 decreased hemoglobin content 0.000153921830559306 0.0044781351288453 1.45947279142695 0.290780141843972 28.1 28 1 abnormal retina morphology 4.71625645302067e-06 0.00023016810144415 1.45794721011187 0.29047619047619 28.1 28 1 abnormal cranial ganglia morphology 0.0599674470686693 0.354790406540801 1.45717621740424 0.290322580645161 28.1 28 1 preaxial polydactyly 0.0599674470686693 0.354790406540801 1.45717621740424 0.290322580645161 28.1 28 1 decreased body size 1.07214342321364e-18 5.33391353048786e-16 1.45291546823055 0.289473684210526 28.1 28 1 increased grooming behavior 0.0406670374092141 0.264814805118901 1.45291546823055 0.289473684210526 28.1 28 1 incomplete somite formation 0.0406670374092141 0.264814805118901 1.45291546823055 0.289473684210526 28.1 28 1 decreased neuron apoptosis 0.0406670374092141 0.264814805118901 1.45291546823055 0.289473684210526 28.1 28 1 abnormal myocardial trabeculae morphology 0.0278848135014093 0.212771391364281 1.44998028546645 0.288888888888889 28.1 28 1 cachexia 0.0012711178276492 0.0226659899374723 1.44783534421576 0.288461538461538 28.1 28 1 absent corpus luteum 0.0192755905269777 0.170633563828673 1.44783534421576 0.288461538461538 28.1 28 1 decreased kidney weight 0.0192755905269777 0.170633563828673 1.44783534421576 0.288461538461538 28.1 28 1 abnormal brain wave pattern 0.0192755905269777 0.170633563828673 1.44783534421576 0.288461538461538 28.1 28 1 abnormal spermatogenesis 2.46535801211027e-05 0.00102209634252072 1.44573703212269 0.28804347826087 28.1 28 1 seminiferous tubule degeneration 0.00657613929607807 0.0778959357094962 1.44386867203982 0.287671232876712 28.1 28 1 decreased grip strength 4.71902439141775e-06 0.00023016810144415 1.44386867203982 0.287671232876712 28.1 28 1 decreased body weight 1.14515438484435e-27 2.84857153230032e-24 1.4433132952139 0.287560581583199 28.1 28 1 abnormal embryo development 0.000300532271137774 0.00758958400462144 1.43931866572037 0.286764705882353 28.1 28 1 abnormal enzyme/coenzyme activity 0.000109928631158977 0.00347179828133561 1.43861346304241 0.286624203821656 28.1 28 1 abnormal lung morphology 0.000759162514680296 0.0151468795376493 1.43404643617561 0.285714285714286 28.1 28 1 abnormal pancreas morphology 0.0367243748447562 0.246274700594065 1.43404643617561 0.285714285714286 28.1 28 1 abnormal anxiety-related response 0.121904724612912 0.545295503069687 1.43404643617561 0.285714285714286 28.1 28 1 abnormal hematopoietic system physiology 0.121904724612912 0.545295503069687 1.43404643617561 0.285714285714286 28.1 28 1 liver degeneration 0.121904724612912 0.545295503069687 1.43404643617561 0.285714285714286 28.1 28 1 decreased cochlear outer hair cell number 0.121904724612912 0.545295503069687 1.43404643617561 0.285714285714286 28.1 28 1 increased acute inflammation 0.121904724612912 0.545295503069687 1.43404643617561 0.285714285714286 28.1 28 1 complete atrioventricular septal defect 0.121904724612912 0.545295503069687 1.43404643617561 0.285714285714286 28.1 28 1 absent segment of posterior cerebral artery 0.121904724612912 0.545295503069687 1.43404643617561 0.285714285714286 28.1 28 1 embryonic lethality between somite formation and embryo turning, complete penetrance 0.00853907033299976 0.0938238508747216 1.43404643617561 0.285714285714286 28.1 28 1 abnormal eye development 0.0175052812554707 0.158921120886801 1.43404643617561 0.285714285714286 28.1 28 1 thick pulmonary interalveolar septum 0.0539075741965333 0.329067707518715 1.43404643617561 0.285714285714286 28.1 28 1 ovary cysts 0.0539075741965333 0.329067707518715 1.43404643617561 0.285714285714286 28.1 28 1 abnormal embryonic epiblast morphology 0.0539075741965333 0.329067707518715 1.43404643617561 0.285714285714286 28.1 28 1 decreased triglyceride level 0.0539075741965333 0.329067707518715 1.43404643617561 0.285714285714286 28.1 28 1 small superior cervical ganglion 0.080222714765216 0.40394003300867 1.43404643617561 0.285714285714286 28.1 28 1 abnormal hormone level 0.080222714765216 0.40394003300867 1.43404643617561 0.285714285714286 28.1 28 1 abnormal heart development 0.000129250073383132 0.00389708554594596 1.42950831454214 0.284810126582278 28.1 28 1 abnormal behavior 5.48496295879614e-07 3.68752577297443e-05 1.42630877554876 0.284172661870504 28.1 28 1 increased circulating alkaline phosphatase level 0.000118471664609391 0.00366084802131504 1.42519429768069 0.283950617283951 28.1 28 1 muscular ventricular septal defect 0.0158820361230456 0.149439622803621 1.42209604920748 0.283333333333333 28.1 28 1 decreased circulating glucose level 6.41756378390394e-07 4.25698397665628e-05 1.42119655771525 0.283154121863799 28.1 28 1 abnormal coat/ hair morphology 0.0228652258031342 0.19302028910939 1.42051769621168 0.283018867924528 28.1 28 1 abnormal mesoderm development 0.0228652258031342 0.19302028910939 1.42051769621168 0.283018867924528 28.1 28 1 increased circulating bilirubin level 0.0228652258031342 0.19302028910939 1.42051769621168 0.283018867924528 28.1 28 1 abnormal CNS synaptic transmission 0.00248991436582201 0.03765144063819 1.41956111863848 0.282828282828283 28.1 28 1 acanthosis 0.048426453528552 0.304578516187795 1.41566122545541 0.282051282051282 28.1 28 1 abnormal ovary morphology 0.010071531809435 0.106608235642424 1.41384859904637 0.28169014084507 28.1 28 1 increased fatty acid level 0.0716103850356589 0.376175191005464 1.41163946061036 0.28125 28.1 28 1 abnormal auditory brainstem response waveform shape 0.0716103850356589 0.376175191005464 1.41163946061036 0.28125 28.1 28 1 reduced fertility 0.000485508502642066 0.0109791127302013 1.40825423408612 0.280575539568345 28.1 28 1 abnormal eye morphology 0.000485508502642066 0.0109791127302013 1.40825423408612 0.280575539568345 28.1 28 1 double outlet right ventricle 0.00207013620881117 0.0326950083772558 1.40724182989195 0.280373831775701 28.1 28 1 insulin resistance 0.000680399545071606 0.0141041155697135 1.40688646579349 0.28030303030303 28.1 28 1 delayed bone ossification 0.00914253242137607 0.097815266228701 1.40536550745209 0.28 28.1 28 1 abnormal thyroid gland morphology 0.107719267481459 0.498514749507215 1.40536550745209 0.28 28.1 28 1 abnormal primitive streak morphology 0.107719267481459 0.498514749507215 1.40536550745209 0.28 28.1 28 1 abnormal placenta morphology 0.00829530813473668 0.093793540841625 1.39774146310787 0.278481012658228 28.1 28 1 abnormal nervous system physiology 0.0017179394823271 0.0292696880978675 1.39663652914494 0.278260869565217 28.1 28 1 abnormal axon morphology 0.0024183062684607 0.0366801026999755 1.39421181294851 0.277777777777778 28.1 28 1 abnormal forebrain development 0.0118168152318889 0.121715643434052 1.39421181294851 0.277777777777778 28.1 28 1 abnormal mitral valve morphology 0.16655946274514 0.556503241878489 1.39421181294851 0.277777777777778 28.1 28 1 abnormal mammary gland morphology 0.16655946274514 0.556503241878489 1.39421181294851 0.277777777777778 28.1 28 1 abnormal retinal rod cell morphology 0.16655946274514 0.556503241878489 1.39421181294851 0.277777777777778 28.1 28 1 abnormal iron level 0.16655946274514 0.556503241878489 1.39421181294851 0.277777777777778 28.1 28 1 abnormal redox activity 0.16655946274514 0.556503241878489 1.39421181294851 0.277777777777778 28.1 28 1 long tibia 0.16655946274514 0.556503241878489 1.39421181294851 0.277777777777778 28.1 28 1 abnormal anterior eye segment morphology 0.16655946274514 0.556503241878489 1.39421181294851 0.277777777777778 28.1 28 1 darkened coat color 0.16655946274514 0.556503241878489 1.39421181294851 0.277777777777778 28.1 28 1 jerky movement 0.16655946274514 0.556503241878489 1.39421181294851 0.277777777777778 28.1 28 1 decreased fluid intake 0.16655946274514 0.556503241878489 1.39421181294851 0.277777777777778 28.1 28 1 abnormal microglial cell morphology 0.0953545796115184 0.450084472075241 1.3845965590661 0.275862068965517 28.1 28 1 increased susceptibility to induced arthritis 0.0953545796115184 0.450084472075241 1.3845965590661 0.275862068965517 28.1 28 1 enlarged epididymis 0.0953545796115184 0.450084472075241 1.3845965590661 0.275862068965517 28.1 28 1 postnatal lethality, incomplete penetrance 3.9772643448941e-11 6.18340316120255e-09 1.37850238407021 0.274647887323944 28.1 28 1 abnormal thrombosis 0.0350800838321626 0.243395936883656 1.37780932103146 0.274509803921569 28.1 28 1 alopecia 0.00560500877599161 0.069538450525083 1.37366553359979 0.273684210526316 28.1 28 1 increased heart weight 0.000974629958401491 0.0185777166400284 1.37214515116083 0.273381294964029 28.1 28 1 obese 0.0124620195399611 0.127046203301858 1.36886250725853 0.272727272727273 28.1 28 1 renal interstitial fibrosis 0.0510737063395451 0.314081197823531 1.36886250725853 0.272727272727273 28.1 28 1 increased myocardial infarction size 0.145282795513077 0.556503241878489 1.36886250725853 0.272727272727273 28.1 28 1 parakeratosis 0.145282795513077 0.556503241878489 1.36886250725853 0.272727272727273 28.1 28 1 abnormal heart morphology 2.95256309629558e-05 0.00117904355250412 1.36886250725853 0.272727272727273 28.1 28 1 increased sensitivity to xenobiotic induced morbidity/mortality 0.00326669710582718 0.0478553414952208 1.36886250725853 0.272727272727273 28.1 28 1 abnormal vascular development 0.0197200215019434 0.174257738849322 1.36886250725853 0.272727272727273 28.1 28 1 abnormal platelet physiology 0.0315150327475234 0.227557747342422 1.36886250725853 0.272727272727273 28.1 28 1 abnormal T-helper 2 physiology 0.0315150327475234 0.227557747342422 1.36886250725853 0.272727272727273 28.1 28 1 abnormal tooth development 0.0845569069931302 0.421513639569963 1.36886250725853 0.272727272727273 28.1 28 1 absent vibrissae 0.0845569069931302 0.421513639569963 1.36886250725853 0.272727272727273 28.1 28 1 abnormal craniofacial morphology 0.0046024668770505 0.0607616087737635 1.36443253150689 0.271844660194175 28.1 28 1 reduced female fertility 3.40324783837429e-05 0.00133316204692221 1.36296223783069 0.271551724137931 28.1 28 1 infertility 0.00417002329765874 0.0582749042299219 1.36033376889555 0.271028037383178 28.1 28 1 abnormal intestinal epithelium morphology 0.0456908067122614 0.293684448828812 1.35935651762479 0.270833333333333 28.1 28 1 abnormal angiogenesis 0.0160243361527521 0.149439622803621 1.35653041259855 0.27027027027027 28.1 28 1 increased brown adipose tissue amount 0.0751039379338305 0.381656885823092 1.35653041259855 0.27027027027027 28.1 28 1 impaired skeletal muscle contractility 0.0751039379338305 0.381656885823092 1.35653041259855 0.27027027027027 28.1 28 1 abnormal respiratory electron transport chain 0.0751039379338305 0.381656885823092 1.35653041259855 0.27027027027027 28.1 28 1 enlarged liver 0.00587825696796753 0.0725665717509639 1.35517388218595 0.27 28.1 28 1 abnormal hair follicle morphology 0.0254570531035549 0.21024233285188 1.35437718972141 0.26984126984127 28.1 28 1 abnormal testis morphology 0.00342266696988685 0.0489303683195031 1.35299163760916 0.269565217391304 28.1 28 1 hydroencephaly 0.00342266696988685 0.0489303683195031 1.35299163760916 0.269565217391304 28.1 28 1 no spontaneous movement 0.12731636046023 0.545295503069687 1.35131298793471 0.269230769230769 28.1 28 1 increased embryonic tissue cell apoptosis 0.0144479728185792 0.14520942378269 1.35131298793471 0.269230769230769 28.1 28 1 decreased compact bone thickness 0.0228908483566914 0.19302028910939 1.34843172356811 0.26865671641791 28.1 28 1 male infertility 3.94889048513844e-09 4.27081090512255e-07 1.34709133418086 0.268389662027833 28.1 28 1 perinatal lethality, complete penetrance 0.000120091281802034 0.00368798843805629 1.34315616909405 0.267605633802817 28.1 28 1 decreased liver weight 0.0205901502357002 0.176918821109859 1.34315616909405 0.267605633802817 28.1 28 1 cleft palate 0.00230526286260774 0.0353971689551652 1.34099762161459 0.267175572519084 28.1 28 1 thin ventricular wall 0.0106006136394073 0.111496940499052 1.33844334043057 0.266666666666667 28.1 28 1 epidermal hyperplasia 0.0328431158039485 0.234762214259546 1.33844334043057 0.266666666666667 28.1 28 1 abnormal ovarian follicle morphology 0.0595060310079582 0.354458051443841 1.33844334043057 0.266666666666667 28.1 28 1 increased circulating corticosterone level 0.0595060310079582 0.354458051443841 1.33844334043057 0.266666666666667 28.1 28 1 abnormal hair cycle 0.111989160046689 0.511367752505256 1.33844334043057 0.266666666666667 28.1 28 1 abnormal nervous system morphology 0.0166756617558326 0.154203377760719 1.33420776023933 0.265822784810127 28.1 28 1 increased bone mineral density 0.00500527087546844 0.0636859913183005 1.33252102476494 0.265486725663717 28.1 28 1 abnormal embryonic tissue morphology 0.00155294850450297 0.0271084870522887 1.33161454787735 0.26530612244898 28.1 28 1 cardiac hypertrophy 0.00863127048842163 0.0938238508747216 1.33161454787735 0.26530612244898 28.1 28 1 increased circulating LDL cholesterol level 0.053067568704906 0.325939696675194 1.33161454787735 0.26530612244898 28.1 28 1 decreased neutrophil cell number 0.00452491392336198 0.0607616087737635 1.32986357542781 0.264957264957265 28.1 28 1 kinked tail 0.00779051093637538 0.0890983722033736 1.32860184528034 0.264705882352941 28.1 28 1 abnormal inhibitory postsynaptic currents 0.0264347214877618 0.211224030958091 1.32860184528034 0.264705882352941 28.1 28 1 decreased regulatory T cell number 0.0988089224402952 0.465065647247369 1.32860184528034 0.264705882352941 28.1 28 1 abnormal skin physiology 0.0988089224402952 0.465065647247369 1.32860184528034 0.264705882352941 28.1 28 1 cochlear outer hair cell degeneration 0.0237353080672551 0.199128427714324 1.32450122230108 0.263888888888889 28.1 28 1 absent vitelline blood vessels 0.0423403480756933 0.274991164068634 1.32083224384595 0.263157894736842 28.1 28 1 abnormal triglyceride level 0.196995994963605 0.603224305780517 1.32083224384595 0.263157894736842 28.1 28 1 small superior vagus ganglion 0.196995994963605 0.603224305780517 1.32083224384595 0.263157894736842 28.1 28 1 abnormal digestive system development 0.196995994963605 0.603224305780517 1.32083224384595 0.263157894736842 28.1 28 1 decreased liver regeneration 0.196995994963605 0.603224305780517 1.32083224384595 0.263157894736842 28.1 28 1 Leydig cell hypoplasia 0.196995994963605 0.603224305780517 1.32083224384595 0.263157894736842 28.1 28 1 decreased circulating magnesium level 0.196995994963605 0.603224305780517 1.32083224384595 0.263157894736842 28.1 28 1 impaired coordination 3.13180900701993e-06 0.000158987242958409 1.3200687569998 0.263005780346821 28.1 28 1 abnormal posture 0.0191636366148955 0.170633563828673 1.31753016323634 0.2625 28.1 28 1 abnormal blood vessel morphology 0.00223974580470788 0.0344976327505317 1.3153667311128 0.262068965517241 28.1 28 1 arrest of spermatogenesis 0.0172312175929089 0.158466500358229 1.31454256649431 0.261904761904762 28.1 28 1 abnormal nervous system electrophysiology 0.0172312175929089 0.158466500358229 1.31454256649431 0.261904761904762 28.1 28 1 skin edema 0.0774811210893495 0.392534192891562 1.31454256649431 0.261904761904762 28.1 28 1 abnormal vibrissa morphology 0.0774811210893495 0.392534192891562 1.31454256649431 0.261904761904762 28.1 28 1 abnormal cytotoxic T cell physiology 0.0774811210893495 0.392534192891562 1.31454256649431 0.261904761904762 28.1 28 1 abnormal coat appearance 0.0303758009409427 0.220935101873084 1.30934674607338 0.260869565217391 28.1 28 1 perimembraneous ventricular septal defect 0.0303758009409427 0.220935101873084 1.30934674607338 0.260869565217391 28.1 28 1 delayed wound healing 0.0688138010544475 0.373992418451224 1.30934674607338 0.260869565217391 28.1 28 1 abnormal blood vessel physiology 0.170512585965779 0.564780369626999 1.30934674607338 0.260869565217391 28.1 28 1 failure of embryo implantation 0.170512585965779 0.564780369626999 1.30934674607338 0.260869565217391 28.1 28 1 abnormal postnatal growth 0.170512585965779 0.564780369626999 1.30934674607338 0.260869565217391 28.1 28 1 conjunctivitis 0.170512585965779 0.564780369626999 1.30934674607338 0.260869565217391 28.1 28 1 abnormal nasal cavity morphology 0.170512585965779 0.564780369626999 1.30934674607338 0.260869565217391 28.1 28 1 abnormal cardiovascular development 0.170512585965779 0.564780369626999 1.30934674607338 0.260869565217391 28.1 28 1 increased susceptibility to fungal infection 0.170512585965779 0.564780369626999 1.30934674607338 0.260869565217391 28.1 28 1 decreased effector memory CD8-positive, alpha-beta T cell number 0.170512585965779 0.564780369626999 1.30934674607338 0.260869565217391 28.1 28 1 increased body length 0.061215174737413 0.354790406540801 1.3049822569198 0.26 28.1 28 1 decreased circulating alkaline phosphatase level 0.061215174737413 0.354790406540801 1.3049822569198 0.26 28.1 28 1 abnormal circulating protein level 0.061215174737413 0.354790406540801 1.3049822569198 0.26 28.1 28 1 decreased oocyte number 0.061215174737413 0.354790406540801 1.3049822569198 0.26 28.1 28 1 diluted coat color 0.0545331890143486 0.329250746779592 1.30126435875194 0.259259259259259 28.1 28 1 abnormal mandible morphology 0.0545331890143486 0.329250746779592 1.30126435875194 0.259259259259259 28.1 28 1 abnormal small intestine morphology 0.0545331890143486 0.329250746779592 1.30126435875194 0.259259259259259 28.1 28 1 neurodegeneration 0.0545331890143486 0.329250746779592 1.30126435875194 0.259259259259259 28.1 28 1 abnormal neuronal precursor proliferation 0.0545331890143486 0.329250746779592 1.30126435875194 0.259259259259259 28.1 28 1 abnormal trigeminal ganglion morphology 0.148562076663013 0.556503241878489 1.30126435875194 0.259259259259259 28.1 28 1 thin epidermis 0.148562076663013 0.556503241878489 1.30126435875194 0.259259259259259 28.1 28 1 abnormal skin appearance 0.148562076663013 0.556503241878489 1.30126435875194 0.259259259259259 28.1 28 1 decreased bone ossification 0.148562076663013 0.556503241878489 1.30126435875194 0.259259259259259 28.1 28 1 abnormal postnatal growth/weight/body size 0.130083668908609 0.545295503069687 1.29526774880377 0.258064516129032 28.1 28 1 pale kidney 0.130083668908609 0.545295503069687 1.29526774880377 0.258064516129032 28.1 28 1 neonatal lethality, incomplete penetrance 0.000112378333694721 0.00351624031529079 1.29339957416608 0.257692307692308 28.1 28 1 abnormal skin morphology 0.0388262424750811 0.256521323125536 1.29281459018861 0.257575757575758 28.1 28 1 abnormal artery morphology 0.114351696832367 0.519543097480389 1.29064179255805 0.257142857142857 28.1 28 1 holoprosencephaly 0.114351696832367 0.519543097480389 1.29064179255805 0.257142857142857 28.1 28 1 decreased bone mineralization 0.114351696832367 0.519543097480389 1.29064179255805 0.257142857142857 28.1 28 1 abnormal intestine morphology 0.0311051173078222 0.225251759252424 1.28870389196862 0.256756756756757 28.1 28 1 postnatal lethality, complete penetrance 3.90422290673174e-06 0.000194235089609904 1.28729816097111 0.256476683937824 28.1 28 1 decreased startle reflex 0.00847316627070212 0.0938238508747216 1.28696475041401 0.256410256410256 28.1 28 1 abnormal circulating hormone level 0.100842961133434 0.471960236725152 1.28696475041401 0.256410256410256 28.1 28 1 kidney failure 0.0891653276416562 0.438337455550632 1.28397180913397 0.255813953488372 28.1 28 1 decreased body length 0.000106667647868663 0.00340174069324743 1.28226779877016 0.255474452554745 28.1 28 1 increased circulating glucose level 0.00456235972106699 0.0607616087737635 1.28148830466756 0.25531914893617 28.1 28 1 cleft secondary palate 0.0180889810678603 0.163467610517493 1.28148830466756 0.25531914893617 28.1 28 1 hepatic necrosis 0.0790160897754054 0.399428184370706 1.28148830466756 0.25531914893617 28.1 28 1 abnormal cued conditioning behavior 0.0701561268892094 0.376175191005464 1.27939436952922 0.254901960784314 28.1 28 1 abnormal learning/memory/conditioning 0.062393047251801 0.357609919444366 1.27760500677463 0.254545454545455 28.1 28 1 abnormal rostral-caudal axis patterning 0.062393047251801 0.357609919444366 1.27760500677463 0.254545454545455 28.1 28 1 increased hemoglobin content 0.0555697354805148 0.335102344261286 1.27605826947829 0.254237288135593 28.1 28 1 increased circulating free fatty acid level 0.0395422734239578 0.26021535751877 1.27246373914173 0.253521126760563 28.1 28 1 abnormal skeletal muscle fiber morphology 0.0395422734239578 0.26021535751877 1.27246373914173 0.253521126760563 28.1 28 1 abnormal seminiferous tubule morphology 0.00465062373879018 0.060886455527582 1.27197954441603 0.253424657534247 28.1 28 1 abnormal motor coordination/ balance 0.0184069042972078 0.165296658625647 1.26746528449864 0.252525252525253 28.1 28 1 female infertility 0.000229193142322565 0.00606508448433383 1.26422514768113 0.25187969924812 28.1 28 1 abnormal rib morphology 0.00714202709544727 0.0842597102178709 1.26408537707331 0.251851851851852 28.1 28 1 respiratory failure 0.00472814232441794 0.0617388663096568 1.26310050338646 0.251655629139073 28.1 28 1 reduced male fertility 0.000693952049638398 0.0142661630039299 1.26031834368737 0.251101321585903 28.1 28 1 abnormal suckling behavior 0.0287563924488304 0.21908583833527 1.25479063165366 0.25 28.1 28 1 abnormal hair growth 0.0799072385549565 0.403183074858934 1.25479063165366 0.25 28.1 28 1 abnormal gametogenesis 0.10186253474236 0.473679740525433 1.25479063165366 0.25 28.1 28 1 omphalocele 0.10186253474236 0.473679740525433 1.25479063165366 0.25 28.1 28 1 cochlear hair cell degeneration 0.10186253474236 0.473679740525433 1.25479063165366 0.25 28.1 28 1 decreased sensitivity to induced morbidity/mortality 0.10186253474236 0.473679740525433 1.25479063165366 0.25 28.1 28 1 lethality, incomplete penetrance 0.10186253474236 0.473679740525433 1.25479063165366 0.25 28.1 28 1 embryonic lethality, incomplete penetrance 0.10186253474236 0.473679740525433 1.25479063165366 0.25 28.1 28 1 abnormal urine homeostasis 0.0231376740053855 0.194771452075792 1.25479063165366 0.25 28.1 28 1 abnormal neuromuscular synapse morphology 0.044811261876192 0.289412259504991 1.25479063165366 0.25 28.1 28 1 decreased circulating LDL cholesterol level 0.0562561159938978 0.338421012176108 1.25479063165366 0.25 28.1 28 1 abnormal tooth morphology 0.0562561159938978 0.338421012176108 1.25479063165366 0.25 28.1 28 1 short mandible 0.0709772124737082 0.376175191005464 1.25479063165366 0.25 28.1 28 1 abnormal seminal vesicle morphology 0.0709772124737082 0.376175191005464 1.25479063165366 0.25 28.1 28 1 heart right ventricle hypertrophy 0.131154315124772 0.545295503069687 1.25479063165366 0.25 28.1 28 1 head tilt 0.131154315124772 0.545295503069687 1.25479063165366 0.25 28.1 28 1 narrow eye opening 0.131154315124772 0.545295503069687 1.25479063165366 0.25 28.1 28 1 abnormal vertebral body morphology 0.149574763532925 0.556503241878489 1.25479063165366 0.25 28.1 28 1 polydipsia 0.149574763532925 0.556503241878489 1.25479063165366 0.25 28.1 28 1 myoclonus 0.171341863962278 0.565269080379532 1.25479063165366 0.25 28.1 28 1 shortened head 0.171341863962278 0.565269080379532 1.25479063165366 0.25 28.1 28 1 prolonged QRS complex duration 0.171341863962278 0.565269080379532 1.25479063165366 0.25 28.1 28 1 abnormal foregut morphology 0.197396818052398 0.603224305780517 1.25479063165366 0.25 28.1 28 1 decreased body height 0.197396818052398 0.603224305780517 1.25479063165366 0.25 28.1 28 1 abnormal body weight 0.197396818052398 0.603224305780517 1.25479063165366 0.25 28.1 28 1 ocular hypertelorism 0.197396818052398 0.603224305780517 1.25479063165366 0.25 28.1 28 1 increased body temperature 0.197396818052398 0.603224305780517 1.25479063165366 0.25 28.1 28 1 increased circulating total protein level 0.197396818052398 0.603224305780517 1.25479063165366 0.25 28.1 28 1 abnormal cellular extravasation 0.197396818052398 0.603224305780517 1.25479063165366 0.25 28.1 28 1 abnormal pericardium morphology 0.229145997867705 0.671764387450369 1.25479063165366 0.25 28.1 28 1 waved hair 0.229145997867705 0.671764387450369 1.25479063165366 0.25 28.1 28 1 anencephaly 0.229145997867705 0.671764387450369 1.25479063165366 0.25 28.1 28 1 abnormal dopamine level 0.229145997867705 0.671764387450369 1.25479063165366 0.25 28.1 28 1 abnormal hair texture 0.229145997867705 0.671764387450369 1.25479063165366 0.25 28.1 28 1 decreased paired-pulse facilitation 0.229145997867705 0.671764387450369 1.25479063165366 0.25 28.1 28 1 absent placental labyrinth 0.229145997867705 0.671764387450369 1.25479063165366 0.25 28.1 28 1 abnormal heart right ventricle morphology 0.229145997867705 0.671764387450369 1.25479063165366 0.25 28.1 28 1 abnormal neuron proliferation 0.229145997867705 0.671764387450369 1.25479063165366 0.25 28.1 28 1 abnormal circulating cytokine level 0.229145997867705 0.671764387450369 1.25479063165366 0.25 28.1 28 1 increased or absent threshold for auditory brainstem response 0.000196264558118256 0.00539456451181395 1.25044879555797 0.249134948096886 28.1 28 1 hypoglycemia 0.0290306056149214 0.220836793477422 1.24129825927028 0.247311827956989 28.1 28 1 decreased rib number 0.0323869770468563 0.233311842493411 1.24069186051148 0.247191011235955 28.1 28 1 small testis 0.000404964468383675 0.00963970445075974 1.23660526018041 0.246376811594203 28.1 28 1 decreased monocyte cell number 0.0635544581523903 0.361417756518002 1.23548616039744 0.246153846153846 28.1 28 1 abnormal liver morphology 0.00402936774358299 0.0566274139105236 1.23376062106728 0.245810055865922 28.1 28 1 abnormal craniofacial bone morphology 0.0803008427428292 0.40394003300867 1.23277676092289 0.245614035087719 28.1 28 1 decreased bone mineral content 0.00221040205528205 0.0343386096179283 1.23066004258339 0.245192307692308 28.1 28 1 impaired balance 0.0262115523498019 0.211224030958091 1.23018689377809 0.245098039215686 28.1 28 1 polydactyly 0.0292115387785287 0.220935101873084 1.22918265957909 0.244897959183673 28.1 28 1 organ of Corti degeneration 0.102142987330649 0.474031121240651 1.22918265957909 0.244897959183673 28.1 28 1 absent kidney 0.102142987330649 0.474031121240651 1.22918265957909 0.244897959183673 28.1 28 1 increased circulating creatinine level 0.0405928263749553 0.264814805118901 1.22560945417334 0.244186046511628 28.1 28 1 Leydig cell hyperplasia 0.131094011771083 0.545295503069687 1.22418598210113 0.24390243902439 28.1 28 1 short humerus 0.131094011771083 0.545295503069687 1.22418598210113 0.24390243902439 28.1 28 1 hemopericardium 0.131094011771083 0.545295503069687 1.22418598210113 0.24390243902439 28.1 28 1 absent gastric milk in neonates 0.0507464016724474 0.312542344747459 1.2226165128933 0.243589743589744 28.1 28 1 decreased circulating chloride level 0.149170507793289 0.556503241878489 1.22087737133869 0.243243243243243 28.1 28 1 abnormal hair follicle development 0.149170507793289 0.556503241878489 1.22087737133869 0.243243243243243 28.1 28 1 impaired fertilization 0.0636858044717058 0.361417756518002 1.21893947074926 0.242857142857143 28.1 28 1 thick epidermis 0.0636858044717058 0.361417756518002 1.21893947074926 0.242857142857143 28.1 28 1 abnormal gait 0.000343132418614449 0.00845090981488555 1.21824333170258 0.242718446601942 28.1 28 1 hyperactivity 9.66441496929111e-05 0.00320536429814822 1.21758659675287 0.242587601078167 28.1 28 1 abnormal locomotor coordination 0.17038047762566 0.564780369626999 1.2167666731187 0.242424242424242 28.1 28 1 single kidney 0.17038047762566 0.564780369626999 1.2167666731187 0.242424242424242 28.1 28 1 abnormal brain morphology 0.00833898504970867 0.0938238508747216 1.21582197849671 0.242236024844721 28.1 28 1 small ovary 0.0406621635575359 0.264814805118901 1.2134239075332 0.241758241758242 28.1 28 1 glomerulosclerosis 0.0903741498279145 0.442530900978223 1.21152198918284 0.241379310344828 28.1 28 1 stomach inflammation 0.195519636255701 0.602297331499761 1.21152198918284 0.241379310344828 28.1 28 1 abnormal outer ear morphology 0.195519636255701 0.602297331499761 1.21152198918284 0.241379310344828 28.1 28 1 decreased bone strength 0.195519636255701 0.602297331499761 1.21152198918284 0.241379310344828 28.1 28 1 increased double-positive T cell number 0.195519636255701 0.602297331499761 1.21152198918284 0.241379310344828 28.1 28 1 increased circulating triglyceride level 0.01261215898895 0.128313887464267 1.21152198918284 0.241379310344828 28.1 28 1 abnormal lipid level 0.0507606461418989 0.312542344747459 1.20943675340111 0.240963855421687 28.1 28 1 abnormal cell adhesion 0.101876848716023 0.473679740525433 1.20831690455537 0.240740740740741 28.1 28 1 abnormal visceral yolk sac morphology 0.0567874141340683 0.340792985907105 1.20714035450225 0.240506329113924 28.1 28 1 short stride length 0.115067559728513 0.52136713082819 1.20459900638751 0.24 28.1 28 1 testicular atrophy 0.115067559728513 0.52136713082819 1.20459900638751 0.24 28.1 28 1 abnormal axon extension 0.115067559728513 0.52136713082819 1.20459900638751 0.24 28.1 28 1 abnormal feces composition 0.225716044548484 0.670010335100662 1.20459900638751 0.24 28.1 28 1 decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 0.225716044548484 0.670010335100662 1.20459900638751 0.24 28.1 28 1 abnormal sleep pattern 0.130259692127979 0.545295503069687 1.20023451723393 0.239130434782609 28.1 28 1 abnormal myelin sheath morphology 0.130259692127979 0.545295503069687 1.20023451723393 0.239130434782609 28.1 28 1 increased circulating HDL cholesterol level 0.0363357121130763 0.246274700594065 1.195038696813 0.238095238095238 28.1 28 1 increased food intake 0.0565950488278568 0.340048753524864 1.195038696813 0.238095238095238 28.1 28 1 disheveled coat 0.147848040109125 0.556503241878489 1.195038696813 0.238095238095238 28.1 28 1 abnormal reproductive system morphology 0.147848040109125 0.556503241878489 1.195038696813 0.238095238095238 28.1 28 1 abnormal scapula morphology 0.262658895759828 0.736184792340926 1.195038696813 0.238095238095238 28.1 28 1 hypoalgesia 0.262658895759828 0.736184792340926 1.195038696813 0.238095238095238 28.1 28 1 abnormal pulmonary alveolus morphology 0.0404948272677045 0.264814805118901 1.19267228355199 0.237623762376238 28.1 28 1 abnormal retinal pigment epithelium morphology 0.0633125953636194 0.361417756518002 1.19205110007097 0.2375 28.1 28 1 no abnormal phenotype detected 5.07922141173084e-15 1.8049376088115e-12 1.18897740544012 0.236887608069164 28.1 28 1 abnormal axial skeleton morphology 0.0708952382290658 0.376175191005464 1.18874901946136 0.236842105263158 28.1 28 1 abnormal frontal bone morphology 0.168339786804826 0.561320669808316 1.18874901946136 0.236842105263158 28.1 28 1 abnormal retinal outer nuclear layer morphology 0.168339786804826 0.561320669808316 1.18874901946136 0.236842105263158 28.1 28 1 decreased total retina thickness 0.168339786804826 0.561320669808316 1.18874901946136 0.236842105263158 28.1 28 1 lethargy 0.0503902354668191 0.311773450257432 1.18732876973679 0.236559139784946 28.1 28 1 cardiac fibrosis 0.0628835991271438 0.360006795923522 1.18097941802697 0.235294117647059 28.1 28 1 abnormal endoderm development 0.192402494605772 0.602297331499761 1.18097941802697 0.235294117647059 28.1 28 1 abnormal bone remodeling 0.192402494605772 0.602297331499761 1.18097941802697 0.235294117647059 28.1 28 1 decreased osteoblast cell number 0.192402494605772 0.602297331499761 1.18097941802697 0.235294117647059 28.1 28 1 improved glucose tolerance 0.00824736387503804 0.0934638616818092 1.17796671542996 0.23469387755102 28.1 28 1 abnormal kidney morphology 0.0124222580620386 0.127046203301858 1.175918077664 0.234285714285714 28.1 28 1 neuron degeneration 0.145917459513487 0.556503241878489 1.17469761261193 0.234042553191489 28.1 28 1 delayed eyelid opening 0.220941955101923 0.663550554344455 1.17113792287674 0.233333333333333 28.1 28 1 abnormal brain vasculature morphology 0.220941955101923 0.663550554344455 1.17113792287674 0.233333333333333 28.1 28 1 abnormal cellular respiration 0.220941955101923 0.663550554344455 1.17113792287674 0.233333333333333 28.1 28 1 abnormal fertility/fecundity 0.0882447525879028 0.436629406036676 1.16884606784176 0.232876712328767 28.1 28 1 astrocytosis 0.0882447525879028 0.436629406036676 1.16884606784176 0.232876712328767 28.1 28 1 enhanced long term potentiation 0.127134550185711 0.545295503069687 1.16516272939268 0.232142857142857 28.1 28 1 decreased spleen weight 0.0990061824623971 0.465553646266943 1.16386377428745 0.231884057971014 28.1 28 1 abnormal response/metabolism to endogenous compounds 0.0778648744053075 0.394077060189628 1.16297668299607 0.231707317073171 28.1 28 1 cataract 0.0393015790045242 0.25931744767574 1.16145909706785 0.231404958677686 28.1 28 1 abnormal snout morphology 0.143580229216302 0.556503241878489 1.1582682753726 0.230769230769231 28.1 28 1 increased susceptibility to injury 0.143580229216302 0.556503241878489 1.1582682753726 0.230769230769231 28.1 28 1 abnormal female meiosis 0.143580229216302 0.556503241878489 1.1582682753726 0.230769230769231 28.1 28 1 increased percent body fat/body weight 0.143580229216302 0.556503241878489 1.1582682753726 0.230769230769231 28.1 28 1 abnormal ureter morphology 0.255235949774961 0.734996437282983 1.1582682753726 0.230769230769231 28.1 28 1 abnormal Mullerian duct morphology 0.255235949774961 0.734996437282983 1.1582682753726 0.230769230769231 28.1 28 1 increased circulating alanine transaminase level 0.0871408672787157 0.43352581471161 1.1582682753726 0.230769230769231 28.1 28 1 decreased heart rate 0.0609467784156887 0.354790406540801 1.15440738112136 0.23 28.1 28 1 kidney cysts 0.0976173976171678 0.460328486393753 1.15305085070876 0.22972972972973 28.1 28 1 increased susceptibility to pharmacologically induced seizures 0.0679398293253128 0.373992418451224 1.15022474568252 0.229166666666667 28.1 28 1 short tail 0.0859114421710065 0.42783726206282 1.14896491573106 0.228915662650602 28.1 28 1 microphthalmia 0.0275449800115773 0.211224030958091 1.14817443419289 0.228758169934641 28.1 28 1 domed cranium 0.109471479644824 0.506152984417288 1.14723714894048 0.228571428571429 28.1 28 1 abnormal intestinal goblet cell morphology 0.215528656909003 0.653415641756423 1.14723714894048 0.228571428571429 28.1 28 1 hypoactivity 0.00109215956606177 0.0205083227603463 1.14495484692005 0.228116710875332 28.1 28 1 neonatal lethality, complete penetrance 0.00036097358756549 0.00880315489283486 1.14472127799983 0.228070175438596 28.1 28 1 abnormal blood homeostasis 0.053327055190375 0.327129592567344 1.14472127799983 0.228070175438596 28.1 28 1 incomplete embryo turning 0.140971781930199 0.556503241878489 1.14472127799983 0.228070175438596 28.1 28 1 decreased anxiety-related response 0.0473408951800217 0.299145980379318 1.14257358329439 0.227642276422764 28.1 28 1 abnormal circadian rhythm 0.184386017165024 0.596049665624427 1.14071875604878 0.227272727272727 28.1 28 1 abnormal enterocyte morphology 0.297181278185343 0.745210553113222 1.14071875604878 0.227272727272727 28.1 28 1 abnormal facial nerve morphology 0.297181278185343 0.745210553113222 1.14071875604878 0.227272727272727 28.1 28 1 abnormal tail movements 0.297181278185343 0.745210553113222 1.14071875604878 0.227272727272727 28.1 28 1 increased activated T cell number 0.297181278185343 0.745210553113222 1.14071875604878 0.227272727272727 28.1 28 1 aphakia 0.297181278185343 0.745210553113222 1.14071875604878 0.227272727272727 28.1 28 1 abnormal female reproductive system physiology 0.297181278185343 0.745210553113222 1.14071875604878 0.227272727272727 28.1 28 1 abnormal basement membrane morphology 0.297181278185343 0.745210553113222 1.14071875604878 0.227272727272727 28.1 28 1 cleft upper lip 0.297181278185343 0.745210553113222 1.14071875604878 0.227272727272727 28.1 28 1 abnormal temporal bone morphology 0.297181278185343 0.745210553113222 1.14071875604878 0.227272727272727 28.1 28 1 decreased susceptibility to viral infection induced morbidity/mortality 0.297181278185343 0.745210553113222 1.14071875604878 0.227272727272727 28.1 28 1 failure of palatal shelf elevation 0.297181278185343 0.745210553113222 1.14071875604878 0.227272727272727 28.1 28 1 increased circulating creatine kinase level 0.297181278185343 0.745210553113222 1.14071875604878 0.227272727272727 28.1 28 1 abnormal motor capabilities/coordination/movement 0.0420748859348617 0.273624258203839 1.14071875604878 0.227272727272727 28.1 28 1 abnormal limb morphology 0.107590573644656 0.498514749507215 1.13767683936598 0.226666666666667 28.1 28 1 absent mature ovarian follicles 0.247442288574973 0.718637119474891 1.1333592802033 0.225806451612903 28.1 28 1 abnormal intestine physiology 0.247442288574973 0.718637119474891 1.1333592802033 0.225806451612903 28.1 28 1 abnormal cardiovascular system physiology 0.0459757295433566 0.295134521907354 1.13214192329653 0.225563909774436 28.1 28 1 corneal opacity 0.120579824057143 0.545295503069687 1.1310788792371 0.225352112676056 28.1 28 1 impaired ovarian folliculogenesis 0.209833086656941 0.637313556848769 1.12931156848829 0.225 28.1 28 1 head bobbing 0.209833086656941 0.637313556848769 1.12931156848829 0.225 28.1 28 1 perinatal lethality 0.209833086656941 0.637313556848769 1.12931156848829 0.225 28.1 28 1 increased startle reflex 0.0927936792597047 0.449737373302209 1.12790169137407 0.224719101123595 28.1 28 1 abnormal muscle physiology 0.0927936792597047 0.449737373302209 1.12790169137407 0.224719101123595 28.1 28 1 abnormal craniofacial development 0.179977634437785 0.582177328561757 1.12675077128083 0.224489795918367 28.1 28 1 increased fluid intake 0.179977634437785 0.582177328561757 1.12675077128083 0.224489795918367 28.1 28 1 enlarged heart 0.0131281389187456 0.1327489656926 1.12498470424121 0.224137931034483 28.1 28 1 cochlear ganglion degeneration 0.155588875648637 0.556503241878489 1.12498470424121 0.224137931034483 28.1 28 1 abnormal heart left ventricle morphology 0.132325540850181 0.545295503069687 1.1153694503588 0.222222222222222 28.1 28 1 skin lesions 0.151976946882463 0.556503241878489 1.1153694503588 0.222222222222222 28.1 28 1 increased circulating aspartate transaminase level 0.151976946882463 0.556503241878489 1.1153694503588 0.222222222222222 28.1 28 1 abnormal autopod morphology 0.204048847932184 0.62088258009946 1.1153694503588 0.222222222222222 28.1 28 1 albuminuria 0.204048847932184 0.62088258009946 1.1153694503588 0.222222222222222 28.1 28 1 cardiomyopathy 0.204048847932184 0.62088258009946 1.1153694503588 0.222222222222222 28.1 28 1 reduced long term depression 0.239635611704498 0.698001854935525 1.1153694503588 0.222222222222222 28.1 28 1 abnormal pharyngeal arch morphology 0.239635611704498 0.698001854935525 1.1153694503588 0.222222222222222 28.1 28 1 abnormal brain commissure morphology 0.285714199235517 0.745210553113222 1.1153694503588 0.222222222222222 28.1 28 1 impaired righting response 0.0993938402777725 0.466935179775183 1.1094990848306 0.221052631578947 28.1 28 1 decreased litter size 0.0103568502953398 0.109163835210414 1.10743087775839 0.220640569395018 28.1 28 1 abnormal colon morphology 0.170959025983852 0.565269080379532 1.10591716688119 0.220338983050847 28.1 28 1 abnormal thoracic vertebrae morphology 0.170959025983852 0.565269080379532 1.10591716688119 0.220338983050847 28.1 28 1 increased circulating chloride level 0.19828560422758 0.605196859528964 1.10421575585522 0.22 28.1 28 1 decreased respiratory quotient 0.19828560422758 0.605196859528964 1.10421575585522 0.22 28.1 28 1 increased tumor growth/size 0.23197845146859 0.677682205552692 1.10176738389101 0.219512195121951 28.1 28 1 lethality at weaning, incomplete penetrance 0.23197845146859 0.677682205552692 1.10176738389101 0.219512195121951 28.1 28 1 increased circulating insulin level 0.0495830928063141 0.309639539541491 1.09794180269695 0.21875 28.1 28 1 abnormal crypts of Lieberkuhn morphology 0.274845195586746 0.745210553113222 1.09794180269695 0.21875 28.1 28 1 kidney cortex cysts 0.274845195586746 0.745210553113222 1.09794180269695 0.21875 28.1 28 1 abnormal lymphatic vessel morphology 0.274845195586746 0.745210553113222 1.09794180269695 0.21875 28.1 28 1 neonatal lethality 0.274845195586746 0.745210553113222 1.09794180269695 0.21875 28.1 28 1 abnormal depression-related behavior 0.274845195586746 0.745210553113222 1.09794180269695 0.21875 28.1 28 1 abnormal embryonic hematopoiesis 0.274845195586746 0.745210553113222 1.09794180269695 0.21875 28.1 28 1 increased rib number 0.141091816932575 0.556503241878489 1.0939200378519 0.217948717948718 28.1 28 1 abnormal skeleton morphology 0.0909875314208635 0.44509633118859 1.09112228839448 0.217391304347826 28.1 28 1 abnormal sternum morphology 0.162038140496745 0.556503241878489 1.09112228839448 0.217391304347826 28.1 28 1 abnormal pulmonary artery morphology 0.332367026024111 0.775575025548757 1.09112228839448 0.217391304347826 28.1 28 1 abnormal innervation pattern to muscle 0.332367026024111 0.775575025548757 1.09112228839448 0.217391304347826 28.1 28 1 dilated heart 0.332367026024111 0.775575025548757 1.09112228839448 0.217391304347826 28.1 28 1 abnormal regulatory T cell physiology 0.332367026024111 0.775575025548757 1.09112228839448 0.217391304347826 28.1 28 1 abnormal chondrocyte physiology 0.332367026024111 0.775575025548757 1.09112228839448 0.217391304347826 28.1 28 1 abnormal basicranium morphology 0.332367026024111 0.775575025548757 1.09112228839448 0.217391304347826 28.1 28 1 abnormal hepatocyte physiology 0.332367026024111 0.775575025548757 1.09112228839448 0.217391304347826 28.1 28 1 abnormal long bone epiphyseal plate morphology 0.187049788969714 0.602297331499761 1.08748521409983 0.216666666666667 28.1 28 1 abnormal eye physiology 0.187049788969714 0.602297331499761 1.08748521409983 0.216666666666667 28.1 28 1 increased circulating phosphate level 0.264591502438624 0.74118396657216 1.08522433007884 0.216216216216216 28.1 28 1 distended abdomen 0.217370368301498 0.65739670656532 1.08256446652472 0.215686274509804 28.1 28 1 abnormal cervical vertebrae morphology 0.217370368301498 0.65739670656532 1.08256446652472 0.215686274509804 28.1 28 1 abnormal response to novel object 0.217370368301498 0.65739670656532 1.08256446652472 0.215686274509804 28.1 28 1 abnormal dendritic spine morphology 0.217370368301498 0.65739670656532 1.08256446652472 0.215686274509804 28.1 28 1 decreased food intake 0.153428934364831 0.556503241878489 1.08007294876517 0.215189873417722 28.1 28 1 decreased exploration in new environment 0.149271641151976 0.556503241878489 1.0755348271317 0.214285714285714 28.1 28 1 spina bifida 0.254923109112079 0.734996437282983 1.0755348271317 0.214285714285714 28.1 28 1 abnormal circulating cholesterol level 0.316906654310037 0.767580625702257 1.0755348271317 0.214285714285714 28.1 28 1 reddish skin 0.316906654310037 0.767580625702257 1.0755348271317 0.214285714285714 28.1 28 1 abnormal somite shape 0.316906654310037 0.767580625702257 1.0755348271317 0.214285714285714 28.1 28 1 abnormal respiration 0.316906654310037 0.767580625702257 1.0755348271317 0.214285714285714 28.1 28 1 enhanced coordination 0.316906654310037 0.767580625702257 1.0755348271317 0.214285714285714 28.1 28 1 increased triglyceride level 0.316906654310037 0.767580625702257 1.0755348271317 0.214285714285714 28.1 28 1 abnormal mitotic spindle morphology 0.316906654310037 0.767580625702257 1.0755348271317 0.214285714285714 28.1 28 1 respiratory distress 0.0594674382616648 0.354458051443841 1.07346250569214 0.213872832369942 28.1 28 1 increased blood urea nitrogen level 0.079082766151788 0.399428184370706 1.07306233327623 0.213793103448276 28.1 28 1 abnormal neurocranium morphology 0.171272662263388 0.565269080379532 1.07075467234445 0.213333333333333 28.1 28 1 short snout 0.120728092495356 0.545295503069687 1.06889572326052 0.212962962962963 28.1 28 1 pulmonary hypoplasia 0.245796748126409 0.714692473365801 1.0679069205563 0.212765957446809 28.1 28 1 dilated heart atrium 0.302970311960884 0.745210553113222 1.06467083897886 0.212121212121212 28.1 28 1 diarrhea 0.302970311960884 0.745210553113222 1.06467083897886 0.212121212121212 28.1 28 1 head tossing 0.302970311960884 0.745210553113222 1.06467083897886 0.212121212121212 28.1 28 1 decreased sensitivity to xenobiotic induced morbidity/mortality 0.302970311960884 0.745210553113222 1.06467083897886 0.212121212121212 28.1 28 1 distended pericardium 0.237167722690209 0.692435105859032 1.06174591909155 0.211538461538462 28.1 28 1 abnormal vertebrae morphology 0.130095689936888 0.545295503069687 1.05908934047831 0.211009174311927 28.1 28 1 persistence of hyaloid vascular system 0.290258626607637 0.745210553113222 1.05666579507676 0.210526315789474 28.1 28 1 seizures 0.126581389937085 0.545295503069687 1.05666579507676 0.210526315789474 28.1 28 1 decreased brain weight 0.228994028189504 0.671764387450369 1.05666579507676 0.210526315789474 28.1 28 1 increased circulating cholesterol level 0.0733162578252655 0.376175191005464 1.05516484934512 0.210227272727273 28.1 28 1 decreased heart weight 0.179780722359365 0.582177328561757 1.05340448089443 0.209876543209877 28.1 28 1 abnormal blood circulation 0.278559340281247 0.745210553113222 1.05052238929143 0.209302325581395 28.1 28 1 abnormal cranium morphology 0.113527585866732 0.517215878834241 1.04878022944186 0.208955223880597 28.1 28 1 rib fusion 0.213864401809791 0.64916131726889 1.04878022944186 0.208955223880597 28.1 28 1 abnormal hair shaft morphology 0.267715747529853 0.745210553113222 1.04565885971138 0.208333333333333 28.1 28 1 abnormal nursing 0.367885501806141 0.841405103326395 1.04565885971138 0.208333333333333 28.1 28 1 abnormal vasodilation 0.367885501806141 0.841405103326395 1.04565885971138 0.208333333333333 28.1 28 1 abnormal primitive streak formation 0.367885501806141 0.841405103326395 1.04565885971138 0.208333333333333 28.1 28 1 abnormal retinal ganglion layer morphology 0.367885501806141 0.841405103326395 1.04565885971138 0.208333333333333 28.1 28 1 hypopigmentation 0.367885501806141 0.841405103326395 1.04565885971138 0.208333333333333 28.1 28 1 abnormal inner cell mass apoptosis 0.367885501806141 0.841405103326395 1.04565885971138 0.208333333333333 28.1 28 1 abnormal parietal bone morphology 0.348572832932907 0.807905670262154 1.03844741929958 0.206896551724138 28.1 28 1 abnormal circulating glucose level 0.348572832932907 0.807905670262154 1.03844741929958 0.206896551724138 28.1 28 1 focal hair loss 0.348572832932907 0.807905670262154 1.03844741929958 0.206896551724138 28.1 28 1 aphagia 0.348572832932907 0.807905670262154 1.03844741929958 0.206896551724138 28.1 28 1 abnormal myocardial fiber morphology 0.176194639030588 0.573645636236027 1.03487887146693 0.206185567010309 28.1 28 1 increased susceptibility to weight gain 0.331636042386285 0.775575025548757 1.0333569907736 0.205882352941176 28.1 28 1 abnormal excitatory postsynaptic currents 0.215391118820852 0.653396839105939 1.0295718003312 0.205128205128205 28.1 28 1 teratozoospermia 0.201435724689216 0.614434537295433 1.0266468804439 0.204545454545455 28.1 28 1 abnormal chondrocyte morphology 0.278618423466358 0.745210553113222 1.02242199616224 0.203703703703704 28.1 28 1 polyphagia 0.278618423466358 0.745210553113222 1.02242199616224 0.203703703703704 28.1 28 1 abnormal epidermal layer morphology 0.248369968533117 0.720910497930138 1.01838080250152 0.202898550724638 28.1 28 1 decreased inflammatory response 0.223203909916074 0.663550554344455 1.01578289229105 0.202380952380952 28.1 28 1 deafness 0.201739948342992 0.614985443018618 1.01397222759891 0.202020202020202 28.1 28 1 abnormal renal glomerulus morphology 0.189053720050494 0.602297331499761 1.01304197784882 0.201834862385321 28.1 28 1 circling 0.2386179358971 0.695852421505318 1.00383250532292 0.2 28.1 28 1 abnormal kidney development 0.288049797300912 0.745210553113222 1.00383250532292 0.2 28.1 28 1 abnormal hindlimb morphology 0.313194473449032 0.761183441821658 1.00383250532292 0.2 28.1 28 1 altered response to myocardial infarction 0.327456960084441 0.769933410964014 1.00383250532292 0.2 28.1 28 1 abnormal female reproductive system morphology 0.343161718724794 0.798890758378965 1.00383250532292 0.2 28.1 28 1 abnormal midbrain development 0.360662888755605 0.831078217489177 1.00383250532292 0.2 28.1 28 1 abnormal hippocampus pyramidal cell morphology 0.360662888755605 0.831078217489177 1.00383250532292 0.2 28.1 28 1 impaired adaptive thermogenesis 0.360662888755605 0.831078217489177 1.00383250532292 0.2 28.1 28 1 abnormal response to new environment 0.380480552390654 0.858167886705792 1.00383250532292 0.2 28.1 28 1 abnormal lactation 0.380480552390654 0.858167886705792 1.00383250532292 0.2 28.1 28 1 disorganized myocardium 0.380480552390654 0.858167886705792 1.00383250532292 0.2 28.1 28 1 decreased acute inflammation 0.403427866120553 0.858167886705792 1.00383250532292 0.2 28.1 28 1 abnormal vertebrae development 0.403427866120553 0.858167886705792 1.00383250532292 0.2 28.1 28 1 increased thermal nociceptive threshold 0.245484879485773 0.714203085053638 0.992801378890804 0.197802197802198 28.1 28 1 abnormal locomotor activation 0.245484879485773 0.714203085053638 0.992801378890804 0.197802197802198 28.1 28 1 increased body weight 0.129755012071177 0.545295503069687 0.985906924870729 0.196428571428571 28.1 28 1 abnormal neuron differentiation 0.227049029447768 0.671764387450369 0.985906924870729 0.196428571428571 28.1 28 1 abnormal gastrulation 0.336566206411845 0.783903032256054 0.984149515022474 0.196078431372549 28.1 28 1 increased kidney weight 0.336566206411845 0.783903032256054 0.984149515022474 0.196078431372549 28.1 28 1 cochlear inner hair cell degeneration 0.336566206411845 0.783903032256054 0.984149515022474 0.196078431372549 28.1 28 1 abnormal lens morphology 0.217560560185807 0.657572167025755 0.980305180979418 0.1953125 28.1 28 1 abnormal limb bone morphology 0.389876369423113 0.858167886705792 0.975948269063954 0.194444444444444 28.1 28 1 abnormal retinal blood vessel morphology 0.389876369423113 0.858167886705792 0.975948269063954 0.194444444444444 28.1 28 1 abnormal object recognition memory 0.412409735706416 0.858167886705792 0.97145081160283 0.193548387096774 28.1 28 1 short femur 0.287256372365383 0.745210553113222 0.969610942641461 0.193181818181818 28.1 28 1 decreased body temperature 0.360232512059854 0.831078217489177 0.965223562810504 0.192307692307692 28.1 28 1 abnormal xiphoid process morphology 0.438711655726647 0.887592715429064 0.965223562810504 0.192307692307692 28.1 28 1 abnormal stomach morphology 0.438711655726647 0.887592715429064 0.965223562810504 0.192307692307692 28.1 28 1 abnormal Schwann cell morphology 0.438711655726647 0.887592715429064 0.965223562810504 0.192307692307692 28.1 28 1 abnormal ocular fundus morphology 0.438711655726647 0.887592715429064 0.965223562810504 0.192307692307692 28.1 28 1 abnormal innervation 0.377758707037098 0.858167886705792 0.961116228500672 0.191489361702128 28.1 28 1 decreased susceptibility to injury 0.336320572582512 0.783903032256054 0.959545777146913 0.191176470588235 28.1 28 1 decreased birth weight 0.309458168034706 0.75247037437569 0.950999215569086 0.189473684210526 28.1 28 1 abnormal long bone metaphysis morphology 0.419109505052826 0.858167886705792 0.949571288818982 0.189189189189189 28.1 28 1 abnormal pancreatic beta cell physiology 0.419109505052826 0.858167886705792 0.949571288818982 0.189189189189189 28.1 28 1 enlarged kidney 0.384098612897309 0.858167886705792 0.947011797474457 0.188679245283019 28.1 28 1 atrioventricular septal defect 0.384098612897309 0.858167886705792 0.947011797474457 0.188679245283019 28.1 28 1 abnormal food intake 0.356737677093978 0.823559138534821 0.945639316608552 0.188405797101449 28.1 28 1 cyanosis 0.238459771588909 0.695799040266759 0.941092973740241 0.1875 28.1 28 1 retinal degeneration 0.326179836697342 0.769933410964014 0.941092973740241 0.1875 28.1 28 1 curly tail 0.403153236154154 0.858167886705792 0.941092973740241 0.1875 28.1 28 1 failure of primitive streak formation 0.444155398810955 0.896782917647931 0.941092973740241 0.1875 28.1 28 1 increased circulating follicle stimulating hormone level 0.444155398810955 0.896782917647931 0.941092973740241 0.1875 28.1 28 1 abnormal diaphragm morphology 0.444155398810955 0.896782917647931 0.941092973740241 0.1875 28.1 28 1 bradykinesia 0.444155398810955 0.896782917647931 0.941092973740241 0.1875 28.1 28 1 increased anxiety-related response 0.285332582336641 0.745210553113222 0.938836156057411 0.18705035971223 28.1 28 1 syndactyly 0.389462783443953 0.858167886705792 0.935776064284082 0.186440677966102 28.1 28 1 abnormal organ of Corti morphology 0.42434153768457 0.865204569664236 0.933797679370162 0.186046511627907 28.1 28 1 abnormal intestinal mucosa morphology 0.42434153768457 0.865204569664236 0.933797679370162 0.186046511627907 28.1 28 1 abnormal male reproductive system morphology 0.42434153768457 0.865204569664236 0.933797679370162 0.186046511627907 28.1 28 1 abnormal palate morphology 0.473483804929176 0.931796649336492 0.92947454196567 0.185185185185185 28.1 28 1 abnormal reproductive system physiology 0.44820486470174 0.903711166989175 0.924582570692167 0.184210526315789 28.1 28 1 hyporesponsive to tactile stimuli 0.44820486470174 0.903711166989175 0.924582570692167 0.184210526315789 28.1 28 1 abnormal long bone hypertrophic chondrocyte zone 0.428564856877771 0.873099984834935 0.921886994684318 0.183673469387755 28.1 28 1 abnormal epidermis stratum corneum morphology 0.428564856877771 0.873099984834935 0.921886994684318 0.183673469387755 28.1 28 1 small kidney 0.388994264474747 0.858167886705792 0.912575004839022 0.181818181818182 28.1 28 1 abnormal astrocyte morphology 0.451356248802477 0.903711166989175 0.912575004839022 0.181818181818182 28.1 28 1 abnormal tail morphology 0.415799838084968 0.858167886705792 0.912575004839022 0.181818181818182 28.1 28 1 increased circulating calcium level 0.432060291107925 0.875916849332488 0.912575004839022 0.181818181818182 28.1 28 1 enlarged pericardium 0.475529862555416 0.935083425380709 0.912575004839022 0.181818181818182 28.1 28 1 dextrocardia 0.475529862555416 0.935083425380709 0.912575004839022 0.181818181818182 28.1 28 1 abnormal long bone morphology 0.435010472614428 0.881538534116814 0.905094881848538 0.180327868852459 28.1 28 1 abnormal heart ventricle morphology 0.421640357914124 0.86075534699334 0.900875325289804 0.179487179487179 28.1 28 1 abnormal heart looping 0.477016180537166 0.937265204649447 0.900875325289804 0.179487179487179 28.1 28 1 abnormal iris morphology 0.477016180537166 0.937265204649447 0.900875325289804 0.179487179487179 28.1 28 1 reduced long term potentiation 0.399915511061109 0.858167886705792 0.896279022609754 0.178571428571429 28.1 28 1 abnormal spleen germinal center morphology 0.507522315933337 0.945459657208677 0.896279022609754 0.178571428571429 28.1 28 1 abnormal retinal inner nuclear layer morphology 0.507522315933337 0.945459657208677 0.896279022609754 0.178571428571429 28.1 28 1 decreased circulating progesterone level 0.507522315933337 0.945459657208677 0.896279022609754 0.178571428571429 28.1 28 1 abnormal ectoderm development 0.478145284200971 0.939112826253388 0.892295560287044 0.177777777777778 28.1 28 1 abnormal myocardium layer morphology 0.441665712050297 0.893206064004157 0.889471840159553 0.177215189873418 28.1 28 1 short maxilla 0.506364252591659 0.945459657208677 0.885734563520227 0.176470588235294 28.1 28 1 abnormal retinal photoreceptor morphology 0.506364252591659 0.945459657208677 0.885734563520227 0.176470588235294 28.1 28 1 overexpanded pulmonary alveoli 0.506364252591659 0.945459657208677 0.885734563520227 0.176470588235294 28.1 28 1 decreased pancreatic beta cell number 0.506364252591659 0.945459657208677 0.885734563520227 0.176470588235294 28.1 28 1 abnormal nervous system development 0.506364252591659 0.945459657208677 0.885734563520227 0.176470588235294 28.1 28 1 abnormal circulating amino acid level 0.479742248844114 0.941877540646988 0.880554829230635 0.175438596491228 28.1 28 1 abnormal social investigation 0.461653835273829 0.91539570764739 0.878353442157559 0.175 28.1 28 1 increased sensitivity to induced morbidity/mortality 0.418417212724864 0.858167886705792 0.872897830715586 0.173913043478261 28.1 28 1 abnormal inner ear morphology 0.504599155452476 0.945459657208677 0.872897830715586 0.173913043478261 28.1 28 1 abnormal forelimb morphology 0.504599155452476 0.945459657208677 0.872897830715586 0.173913043478261 28.1 28 1 decreased retinal photoreceptor cell number 0.540636791558427 0.987396489722164 0.865372849416314 0.172413793103448 28.1 28 1 absent long term depression 0.540636791558427 0.987396489722164 0.865372849416314 0.172413793103448 28.1 28 1 abnormal action potential 0.502212392845822 0.945459657208677 0.860427861705363 0.171428571428571 28.1 28 1 impaired behavioral response to xenobiotic 0.536509362350843 0.980938654059332 0.860427861705363 0.171428571428571 28.1 28 1 atelectasis 0.523389582855716 0.957302637759996 0.848309159427823 0.169014084507042 28.1 28 1 polyuria 0.522087648223702 0.955272545021301 0.847391075921949 0.168831168831169 28.1 28 1 hydronephrosis 0.540283781975578 0.987396489722164 0.836527087769103 0.166666666666667 28.1 28 1 abnormal digit morphology 0.544286093097074 0.993332103139377 0.836527087769103 0.166666666666667 28.1 28 1 increased susceptibility to bacterial infection induced morbidity/mortality 0.544286093097074 0.993332103139377 0.836527087769103 0.166666666666667 28.1 28 1 abnormal cartilage morphology 0.560473261630287 1 0.836527087769103 0.166666666666667 28.1 28 1 abnormal optic nerve morphology 0.560473261630287 1 0.836527087769103 0.166666666666667 28.1 28 1 emphysema 0.572668039391982 1 0.836527087769103 0.166666666666667 28.1 28 1 abnormal cardiovascular system morphology 0.556110603537464 1 0.836527087769103 0.166666666666667 28.1 28 1 abnormal kidney physiology 0.556110603537464 1 0.836527087769103 0.166666666666667 28.1 28 1 renal hypoplasia 0.565835960936389 1 0.836527087769103 0.166666666666667 28.1 28 1 abnormal optic cup morphology 0.572668039391982 1 0.836527087769103 0.166666666666667 28.1 28 1 abnormal joint morphology 0.576022746572664 1 0.82131750435512 0.163636363636364 28.1 28 1 decreased cardiac muscle contractility 0.570167549114438 1 0.820440028388928 0.163461538461538 28.1 28 1 abnormal breathing pattern 0.594234629817078 1 0.813918247559128 0.162162162162162 28.1 28 1 abnormal retinal photoreceptor layer morphology 0.603486943946899 1 0.809542343002358 0.161290322580645 28.1 28 1 decreased neuronal precursor cell number 0.603486943946899 1 0.809542343002358 0.161290322580645 28.1 28 1 decreased susceptibility to bacterial infection induced morbidity/mortality 0.603486943946899 1 0.809542343002358 0.161290322580645 28.1 28 1 hypertension 0.612594926951525 1 0.798503129234144 0.159090909090909 28.1 28 1 abnormal compact bone morphology 0.621615210776204 1 0.792499346307572 0.157894736842105 28.1 28 1 dehydration 0.629667075618259 1 0.788725539896583 0.157142857142857 28.1 28 1 abnormal long term potentiation 0.63299278563874 1 0.784244144783534 0.15625 28.1 28 1 abnormal cartilage development 0.637361966405574 1 0.780758615251163 0.155555555555556 28.1 28 1 irregular heartbeat 0.637361966405574 1 0.780758615251163 0.155555555555556 28.1 28 1 small lens 0.647905943546939 1 0.772178850248403 0.153846153846154 28.1 28 1 abnormal spatial learning 0.701077595221283 1 0.7698102034685 0.153374233128834 28.1 28 1 impaired swimming 0.675649668472613 1 0.760479170699185 0.151515151515152 28.1 28 1 cardiovascular system phenotype 0.661111164760762 1 0.760479170699185 0.151515151515152 28.1 28 1 decreased circulating phosphate level 0.673052365721462 1 0.752874378992193 0.15 28.1 28 1 increased susceptibility to weight loss 0.673052365721462 1 0.752874378992193 0.15 28.1 28 1 maternal effect 0.694519486423064 1 0.749128735315615 0.149253731343284 28.1 28 1 abnormal tibia morphology 0.684041547868718 1 0.747534844389412 0.148936170212766 28.1 28 1 increased systemic arterial blood pressure 0.684041547868718 1 0.747534844389412 0.148936170212766 28.1 28 1 abnormal eye electrophysiology 0.732445796250866 1 0.746652276686472 0.148760330578512 28.1 28 1 abnormal long bone epiphyseal plate proliferative zone 0.694237158296889 1 0.743579633572536 0.148148148148148 28.1 28 1 impaired synaptic plasticity 0.687791666858883 1 0.738112136266856 0.147058823529412 28.1 28 1 abnormal vision 0.687791666858883 1 0.738112136266856 0.147058823529412 28.1 28 1 increased width of hypertrophic chondrocyte zone 0.687791666858883 1 0.738112136266856 0.147058823529412 28.1 28 1 abnormal excitatory postsynaptic potential 0.729094880854975 1 0.734511589260676 0.146341463414634 28.1 28 1 oligodactyly 0.705883416413078 1 0.731961201797966 0.145833333333333 28.1 28 1 abnormal phalanx morphology 0.705883416413078 1 0.731961201797966 0.145833333333333 28.1 28 1 abnormal digestive system physiology 0.746475032554272 1 0.702682753726047 0.14 28.1 28 1 abnormal uterus morphology 0.736742388041487 1 0.697105906474253 0.138888888888889 28.1 28 1 short radius 0.736742388041487 1 0.697105906474253 0.138888888888889 28.1 28 1 abnormal enzyme/coenzyme level 0.769318003093408 1 0.692298279533051 0.137931034482759 28.1 28 1 abnormal vocalization 0.759009225264051 1 0.678265206299273 0.135135135135135 28.1 28 1 abnormal femur morphology 0.803880837321951 1 0.674215861784054 0.134328358208955 28.1 28 1 impaired branching involved in ureteric bud morphogenesis 0.779826500186452 1 0.660416121922976 0.131578947368421 28.1 28 1 decreased threshold for auditory brainstem response 0.779826500186452 1 0.660416121922976 0.131578947368421 28.1 28 1 abnormal lens fiber morphology 0.799226582045204 1 0.643482375207003 0.128205128205128 28.1 28 1 increased vascular permeability 0.799226582045204 1 0.643482375207003 0.128205128205128 28.1 28 1 short limbs 0.875561688892587 1 0.63460675623863 0.126436781609195 28.1 28 1 decreased urine osmolality 0.845695301810189 1 0.614591329789545 0.122448979591837 28.1 28 1 short ulna 0.833950835310391 1 0.612092991050563 0.121951219512195 28.1 28 1 abnormal axon guidance 0.863599605192691 1 0.583623549606351 0.116279069767442 28.1 28 1 increased liver weight 0.935088898020509 1 0.570359378024389 0.113636363636364 28.1 28 1 abnormal photoreceptor outer segment morphology 0.876671724375516 1 0.570359378024389 0.113636363636364 28.1 28 1 abnormal amino acid level 0.876671724375516 1 0.570359378024389 0.113636363636364 28.1 28 1 abnormal facial morphology 0.928805459205477 1 0.528332897538381 0.105263157894737 28.1 28 1 abnormal cochlea morphology 0.958266336155412 1 0.464737270982835 0.0925925925925926 28.1 28 1 decreased tidal volume 3.78264557874927e-05 0.00110050653533787 3.28171147292692 1 28.2 28 2 abnormal immature B cell morphology 0.000162056047416973 0.00374990156232298 3.28171147292692 1 28.2 28 2 absent lungs 0.000694213067988926 0.0112866340302121 3.28171147292692 1 28.2 28 2 decreased transitional stage T2 B cell number 1.62760904632034e-05 0.000547824193629492 2.95354032563423 0.9 28.2 28 2 decreased fatty acid oxidation 6.2973572754901e-05 0.00167536644093921 2.91707686482393 0.888888888888889 28.2 28 2 abnormal pulmonary circulation 0.000240812561236506 0.00493036812438133 2.87149753881106 0.875 28.2 28 2 decreased mortality induced by ionizing radiation 0.000907433597193855 0.0134760661075804 2.81289554822308 0.857142857142857 28.2 28 2 decreased brain cholesterol level 0.000907433597193855 0.0134760661075804 2.81289554822308 0.857142857142857 28.2 28 2 echinocytosis 0.00335499817084868 0.0366837712087301 2.73475956077243 0.833333333333333 28.2 28 2 abnormal parental behavior 0.00335499817084868 0.0366837712087301 2.73475956077243 0.833333333333333 28.2 28 2 abnormal lymph node cortex morphology 0.00335499817084868 0.0366837712087301 2.73475956077243 0.833333333333333 28.2 28 2 enlarged pancreas 0.00335499817084868 0.0366837712087301 2.73475956077243 0.833333333333333 28.2 28 2 ectopic hippocampus pyramidal cells 0.00335499817084868 0.0366837712087301 2.73475956077243 0.833333333333333 28.2 28 2 myocardium hypoplasia 0.00335499817084868 0.0366837712087301 2.73475956077243 0.833333333333333 28.2 28 2 decreased thymocyte apoptosis 5.7605058273868e-06 0.000231117068477817 2.62536917834154 0.8 28.2 28 2 abnormal maternal decidual layer morphology 1.9868654858221e-05 0.000633631781536215 2.57848758587115 0.785714285714286 28.2 28 2 decreased level of surface class I molecules 0.000863249020922121 0.013014132966932 2.55244225672094 0.777777777777778 28.2 28 2 abnormal thymus physiology 0.000863249020922121 0.013014132966932 2.55244225672094 0.777777777777778 28.2 28 2 abnormal leukopoiesis 0.000863249020922121 0.013014132966932 2.55244225672094 0.777777777777778 28.2 28 2 absent cervical lymph nodes 0.000863249020922121 0.013014132966932 2.55244225672094 0.777777777777778 28.2 28 2 decreased transitional stage T1 B cell number 0.000863249020922121 0.013014132966932 2.55244225672094 0.777777777777778 28.2 28 2 increased cardiac muscle glycogen level 0.000863249020922121 0.013014132966932 2.55244225672094 0.777777777777778 28.2 28 2 cerebellum atrophy 0.000863249020922121 0.013014132966932 2.55244225672094 0.777777777777778 28.2 28 2 interstitial pneumonia 0.000223946717472482 0.00464222883093999 2.46128360469519 0.75 28.2 28 2 altered tumor susceptibility 0.000223946717472482 0.00464222883093999 2.46128360469519 0.75 28.2 28 2 absent pre-B cells 0.0029072967050659 0.0337181294398785 2.46128360469519 0.75 28.2 28 2 failure of vascular branching 0.0029072967050659 0.0337181294398785 2.46128360469519 0.75 28.2 28 2 schistocytosis 0.0029072967050659 0.0337181294398785 2.46128360469519 0.75 28.2 28 2 enlarged pituitary gland 0.0029072967050659 0.0337181294398785 2.46128360469519 0.75 28.2 28 2 colon polyps 0.0029072967050659 0.0337181294398785 2.46128360469519 0.75 28.2 28 2 abnormal NK cell morphology 0.0029072967050659 0.0337181294398785 2.46128360469519 0.75 28.2 28 2 pleural effusion 0.0029072967050659 0.0337181294398785 2.46128360469519 0.75 28.2 28 2 increased mammary gland apoptosis 0.0029072967050659 0.0337181294398785 2.46128360469519 0.75 28.2 28 2 delayed intramembranous bone ossification 5.86660646930153e-05 0.00159702792409854 2.40658841347974 0.733333333333333 28.2 28 2 arrested B cell differentiation 2.06491438810393e-11 2.77647272454515e-09 2.4012522972636 0.731707317073171 28.2 28 2 increased lactate dehydrogenase level 0.000186129259875012 0.00399134943050942 2.34407962351923 0.714285714285714 28.2 28 2 increased B-1 B cell number 0.000186129259875012 0.00399134943050942 2.34407962351923 0.714285714285714 28.2 28 2 lysosomal protein accumulation 0.000186129259875012 0.00399134943050942 2.34407962351923 0.714285714285714 28.2 28 2 cellular necrosis 0.00947390960498577 0.0816857890551199 2.34407962351923 0.714285714285714 28.2 28 2 abnormal lacrimal gland morphology 0.00947390960498577 0.0816857890551199 2.34407962351923 0.714285714285714 28.2 28 2 abnormal tumor incidence 0.00947390960498577 0.0816857890551199 2.34407962351923 0.714285714285714 28.2 28 2 abnormal brain ventricular system morphology 0.00947390960498577 0.0816857890551199 2.34407962351923 0.714285714285714 28.2 28 2 abnormal organ of Corti supporting cell morphology 0.00947390960498577 0.0816857890551199 2.34407962351923 0.714285714285714 28.2 28 2 absent popliteal lymph nodes 0.00947390960498577 0.0816857890551199 2.34407962351923 0.714285714285714 28.2 28 2 heart hemorrhage 0.00947390960498577 0.0816857890551199 2.34407962351923 0.714285714285714 28.2 28 2 decreased DN2 thymocyte number 0.00947390960498577 0.0816857890551199 2.34407962351923 0.714285714285714 28.2 28 2 dilated pulmonary alveolar ducts 0.00947390960498577 0.0816857890551199 2.34407962351923 0.714285714285714 28.2 28 2 abnormal outer hair cell kinocilium morphology 0.00947390960498577 0.0816857890551199 2.34407962351923 0.714285714285714 28.2 28 2 ductus venosus stenosis 0.00947390960498577 0.0816857890551199 2.34407962351923 0.714285714285714 28.2 28 2 absent CD4-positive, alpha beta T cells 0.00229471523192312 0.0288946730178202 2.29719803104885 0.7 28.2 28 2 abnormal gas homeostasis 0.00229471523192312 0.0288946730178202 2.29719803104885 0.7 28.2 28 2 absent axillary lymph nodes 0.00229471523192312 0.0288946730178202 2.29719803104885 0.7 28.2 28 2 acanthocytosis 0.00229471523192312 0.0288946730178202 2.29719803104885 0.7 28.2 28 2 abnormal B cell differentiation 2.10485362553551e-20 1.04716467870392e-17 2.27195409664172 0.692307692307692 28.2 28 2 increased foot pad pigmentation 0.000576240540843776 0.00968512395506008 2.27195409664172 0.692307692307692 28.2 28 2 abnormal coping response 0.000576240540843776 0.00968512395506008 2.27195409664172 0.692307692307692 28.2 28 2 abnormal exocrine pancreas morphology 0.000576240540843776 0.00968512395506008 2.27195409664172 0.692307692307692 28.2 28 2 decreased adipocyte glucose uptake 0.000147900450561823 0.00348722626324678 2.25617663763726 0.6875 28.2 28 2 increased pre-B cell number 2.68979304139229e-06 0.000118422304255988 2.23156380159031 0.68 28.2 28 2 decreased B-1 B cell number 1.10568159460911e-08 9.82279630925053e-07 2.18780764861795 0.666666666666667 28.2 28 2 abnormal T cell subpopulation ratio 1.51484298000536e-07 9.91624187569296e-06 2.18780764861795 0.666666666666667 28.2 28 2 abnormal Peyer's patch follicle morphology 0.000114180886334046 0.00280511597247297 2.18780764861795 0.666666666666667 28.2 28 2 abnormal vascular endothelial cell development 0.00173335772671661 0.0228133721968655 2.18780764861795 0.666666666666667 28.2 28 2 increased osteosarcoma incidence 0.00173335772671661 0.0228133721968655 2.18780764861795 0.666666666666667 28.2 28 2 abnormal fatty acid level 0.00173335772671661 0.0228133721968655 2.18780764861795 0.666666666666667 28.2 28 2 abnormal thymus corticomedullary boundary morphology 0.00173335772671661 0.0228133721968655 2.18780764861795 0.666666666666667 28.2 28 2 abnormal pulmonary valve cusp morphology 0.00173335772671661 0.0228133721968655 2.18780764861795 0.666666666666667 28.2 28 2 heart hyperplasia 0.00699539207335347 0.0655406319490273 2.18780764861795 0.666666666666667 28.2 28 2 multifocal hepatic necrosis 0.00699539207335347 0.0655406319490273 2.18780764861795 0.666666666666667 28.2 28 2 increased pheochromocytoma incidence 0.00699539207335347 0.0655406319490273 2.18780764861795 0.666666666666667 28.2 28 2 abnormal posterior eye segment morphology 0.00699539207335347 0.0655406319490273 2.18780764861795 0.666666666666667 28.2 28 2 abnormal incisor color 0.00699539207335347 0.0655406319490273 2.18780764861795 0.666666666666667 28.2 28 2 retropulsion 0.00699539207335347 0.0655406319490273 2.18780764861795 0.666666666666667 28.2 28 2 prolonged RR interval 0.00699539207335347 0.0655406319490273 2.18780764861795 0.666666666666667 28.2 28 2 macrocytosis 0.000441055650239006 0.00803755260050935 2.18780764861795 0.666666666666667 28.2 28 2 decreased B cell proliferation 1.19606840069668e-15 3.71902518341623e-13 2.16011388091392 0.658227848101266 28.2 28 2 abnormal liver development 1.17665691925795e-07 8.13037246292823e-06 2.15655325363769 0.657142857142857 28.2 28 2 abnormal cell death 1.8180804127873e-09 1.84533260195741e-07 2.14024661277843 0.652173913043478 28.2 28 2 abnormal vascular regression 8.6438090200624e-05 0.00220527948075951 2.1331124574025 0.65 28.2 28 2 abnormal thymocyte activation 8.6438090200624e-05 0.00220527948075951 2.1331124574025 0.65 28.2 28 2 increased regulatory T cell number 0.000330334259302774 0.00632081900012038 2.12346036483507 0.647058823529412 28.2 28 2 abnormal spleen periarteriolar lymphoid sheath morphology 0.00127844084658755 0.0178658517184637 2.10967166116731 0.642857142857143 28.2 28 2 vascular smooth muscle hypoplasia 0.00127844084658755 0.0178658517184637 2.10967166116731 0.642857142857143 28.2 28 2 multiple persisting craniopharyngeal ducts 0.00127844084658755 0.0178658517184637 2.10967166116731 0.642857142857143 28.2 28 2 prolonged PR interval 6.45338870564184e-05 0.00170774514949831 2.08836184640804 0.636363636363636 28.2 28 2 abnormal sphenoid bone morphology 0.00503807037681935 0.05060407775959 2.08836184640804 0.636363636363636 28.2 28 2 abnormal food preference 0.00503807037681935 0.05060407775959 2.08836184640804 0.636363636363636 28.2 28 2 kyphoscoliosis 0.000243882745948923 0.0049321815491703 2.07265987763806 0.631578947368421 28.2 28 2 hemolytic anemia 4.76935358043965e-05 0.00133300753161164 2.05106967057933 0.625 28.2 28 2 small pancreas 0.000929647649700975 0.0136430591659656 2.05106967057933 0.625 28.2 28 2 sepsis 0.000929647649700975 0.0136430591659656 2.05106967057933 0.625 28.2 28 2 abnormal cecum morphology 0.0204182644381855 0.13877167428958 2.05106967057933 0.625 28.2 28 2 poor grooming 0.0204182644381855 0.13877167428958 2.05106967057933 0.625 28.2 28 2 abnormal erythrocyte cell number 0.0204182644381855 0.13877167428958 2.05106967057933 0.625 28.2 28 2 abnormal hepatobiliary system morphology 0.0204182644381855 0.13877167428958 2.05106967057933 0.625 28.2 28 2 hypospadia 0.0204182644381855 0.13877167428958 2.05106967057933 0.625 28.2 28 2 elevated level of mitotic sister chromatid exchange 0.0204182644381855 0.13877167428958 2.05106967057933 0.625 28.2 28 2 abnormal miscarriage rate 0.0204182644381855 0.13877167428958 2.05106967057933 0.625 28.2 28 2 abnormal extraembryonic tissue physiology 0.0204182644381855 0.13877167428958 2.05106967057933 0.625 28.2 28 2 abnormal kidney epithelium morphology 0.0204182644381855 0.13877167428958 2.05106967057933 0.625 28.2 28 2 accumulation of giant lysosomes in kidney/renal tubule cells 0.0204182644381855 0.13877167428958 2.05106967057933 0.625 28.2 28 2 abnormal ilium morphology 0.0204182644381855 0.13877167428958 2.05106967057933 0.625 28.2 28 2 abnormal sphingomyelin level 0.0204182644381855 0.13877167428958 2.05106967057933 0.625 28.2 28 2 abnormal olfactory bulb mitral cell layer morphology 0.0204182644381855 0.13877167428958 2.05106967057933 0.625 28.2 28 2 decreased hippocampus pyramidal cell number 0.0204182644381855 0.13877167428958 2.05106967057933 0.625 28.2 28 2 abnormal macrophage activation involved in immune response 0.0204182644381855 0.13877167428958 2.05106967057933 0.625 28.2 28 2 increased brain apoptosis 0.0204182644381855 0.13877167428958 2.05106967057933 0.625 28.2 28 2 decreased vascular endothelial cell proliferation 0.0204182644381855 0.13877167428958 2.05106967057933 0.625 28.2 28 2 increased muscle cell glucose uptake 0.000178281580026662 0.00393531288995927 2.03153567371667 0.619047619047619 28.2 28 2 abnormal cell cycle 1.59901000291012e-18 7.23188614952532e-16 2.02610012676358 0.617391304347826 28.2 28 2 heart inflammation 3.49799716125736e-05 0.00102367858101502 2.01951475257041 0.615384615384615 28.2 28 2 absent teeth 0.00358474522411315 0.0386233616091275 2.01951475257041 0.615384615384615 28.2 28 2 increased pituitary adenoma incidence 0.00358474522411315 0.0386233616091275 2.01951475257041 0.615384615384615 28.2 28 2 absent hypoglossal nerve 0.00358474522411315 0.0386233616091275 2.01951475257041 0.615384615384615 28.2 28 2 decreased cellular sensitivity to gamma-irradiation 0.000670003845396487 0.0109647010883142 2.00549034456645 0.611111111111111 28.2 28 2 abnormal hypoglossal nerve topology 0.000670003845396487 0.0109647010883142 2.00549034456645 0.611111111111111 28.2 28 2 abnormal B cell morphology 0.000129408373421306 0.00308041463048325 1.99756350525987 0.608695652173913 28.2 28 2 subcutaneous edema 2.55058431820308e-05 0.00076887480887664 1.99246767999135 0.607142857142857 28.2 28 2 spleen hyperplasia 1.18337435394288e-11 1.78402648814116e-09 1.96902688375615 0.6 28.2 28 2 abnormal Peyer's patch T cell area morphology 0.000480049729571374 0.00859081800222153 1.96902688375615 0.6 28.2 28 2 enlarged testis 0.014046407335499 0.105242283876668 1.96902688375615 0.6 28.2 28 2 fused cornea and lens 0.014046407335499 0.105242283876668 1.96902688375615 0.6 28.2 28 2 decreased incidence of induced tumors 0.014046407335499 0.105242283876668 1.96902688375615 0.6 28.2 28 2 increased heart rate variability 0.014046407335499 0.105242283876668 1.96902688375615 0.6 28.2 28 2 osteosclerosis 0.014046407335499 0.105242283876668 1.96902688375615 0.6 28.2 28 2 absent inguinal lymph nodes 0.014046407335499 0.105242283876668 1.96902688375615 0.6 28.2 28 2 abnormal hippocampus neuron morphology 0.014046407335499 0.105242283876668 1.96902688375615 0.6 28.2 28 2 abnormal cerebellar granule cell migration 0.014046407335499 0.105242283876668 1.96902688375615 0.6 28.2 28 2 increased circulating fructosamine level 0.014046407335499 0.105242283876668 1.96902688375615 0.6 28.2 28 2 abnormal inferior vena cava valve morphology 0.014046407335499 0.105242283876668 1.96902688375615 0.6 28.2 28 2 decreased trabecular bone connectivity density 0.014046407335499 0.105242283876668 1.96902688375615 0.6 28.2 28 2 abnormal lymph node B cell domain morphology 0.00253451864111037 0.0311339018259854 1.96902688375615 0.6 28.2 28 2 abnormal T cell differentiation 8.87103204614572e-15 2.10158973474167e-12 1.9495315680754 0.594059405940594 28.2 28 2 abnormal germ layer development 0.000342583803205904 0.00648043506064401 1.93919314309318 0.590909090909091 28.2 28 2 abnormal mesenteric lymph node morphology 0.000342583803205904 0.00648043506064401 1.93919314309318 0.590909090909091 28.2 28 2 abnormal ectoplacental cone morphology 0.00178580963598412 0.0234416964090264 1.93041851348642 0.588235294117647 28.2 28 2 failure to gastrulate 2.87802208326635e-07 1.74611705661587e-05 1.92622195150058 0.58695652173913 28.2 28 2 abnormal cell differentiation 1.40961275954107e-06 6.87531713599688e-05 1.92100183781088 0.585365853658537 28.2 28 2 amyloidosis 0.00966466808696315 0.0820507230932452 1.9143316925407 0.583333333333333 28.2 28 2 increased papilloma incidence 0.00966466808696315 0.0820507230932452 1.9143316925407 0.583333333333333 28.2 28 2 abnormal respiratory function 0.00966466808696315 0.0820507230932452 1.9143316925407 0.583333333333333 28.2 28 2 abnormal defecation 0.00966466808696315 0.0820507230932452 1.9143316925407 0.583333333333333 28.2 28 2 decreased mammary gland epithelial cell proliferation 0.00966466808696315 0.0820507230932452 1.9143316925407 0.583333333333333 28.2 28 2 increased fibrosarcoma incidence 0.00966466808696315 0.0820507230932452 1.9143316925407 0.583333333333333 28.2 28 2 persistent right dorsal aorta 0.00966466808696315 0.0820507230932452 1.9143316925407 0.583333333333333 28.2 28 2 prenatal growth retardation 0.00966466808696315 0.0820507230932452 1.9143316925407 0.583333333333333 28.2 28 2 abnormal vitelline vein connection 0.00966466808696315 0.0820507230932452 1.9143316925407 0.583333333333333 28.2 28 2 decreased double-positive T cell number 1.06677592193453e-13 2.2113375881768e-11 1.90339265429761 0.58 28.2 28 2 enlarged adrenal glands 0.00125592035713689 0.0177002939851445 1.89993822116822 0.578947368421053 28.2 28 2 increased susceptibility to ischemic brain injury 0.00125592035713689 0.0177002939851445 1.89993822116822 0.578947368421053 28.2 28 2 decreased eye pigmentation 0.00125592035713689 0.0177002939851445 1.89993822116822 0.578947368421053 28.2 28 2 increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 0.00125592035713689 0.0177002939851445 1.89993822116822 0.578947368421053 28.2 28 2 increased leukemia incidence 0.000173177270843226 0.00391616782929567 1.89329508053476 0.576923076923077 28.2 28 2 increased B cell proliferation 1.61623066475499e-08 1.34012459285934e-06 1.89115576405958 0.576271186440678 28.2 28 2 increased hemangioma incidence 0.00665981772748063 0.0634724007552034 1.87526369881538 0.571428571428571 28.2 28 2 abnormal viscerocranium morphology 0.00665981772748063 0.0634724007552034 1.87526369881538 0.571428571428571 28.2 28 2 spina bifida occulta 0.00665981772748063 0.0634724007552034 1.87526369881538 0.571428571428571 28.2 28 2 abnormal eye pigmentation 0.000882407262297655 0.0132064724508873 1.87526369881538 0.571428571428571 28.2 28 2 abnormal hematopoietic system physiology 0.000882407262297655 0.0132064724508873 1.87526369881538 0.571428571428571 28.2 28 2 abnormal erythropoiesis 1.0124365513189e-13 2.18994427948326e-11 1.87526369881538 0.571428571428571 28.2 28 2 increased T cell derived lymphoma incidence 3.7727447105978e-07 2.23388996544952e-05 1.87526369881538 0.571428571428571 28.2 28 2 abnormal lymphocyte physiology 1.30799303975319e-06 6.5727432485459e-05 1.8548803977413 0.565217391304348 28.2 28 2 decreased mast cell number 0.00459792420149387 0.0466830059233306 1.84596270352139 0.5625 28.2 28 2 increased B cell derived lymphoma incidence 6.66196730983504e-07 3.64211949081641e-05 1.83775842483908 0.56 28.2 28 2 extramedullary hematopoiesis 7.67819561263065e-13 1.46919319895529e-10 1.826612989648 0.556603773584906 28.2 28 2 abnormal atrioventricular cushion morphology 0.000305624163248554 0.00600293685940519 1.82317304051496 0.555555555555556 28.2 28 2 abnormal white adipose tissue morphology 0.00318056687421868 0.0354782964108474 1.82317304051496 0.555555555555556 28.2 28 2 abnormal redox activity 0.00318056687421868 0.0354782964108474 1.82317304051496 0.555555555555556 28.2 28 2 long tibia 0.00318056687421868 0.0354782964108474 1.82317304051496 0.555555555555556 28.2 28 2 abnormal thymus lobule morphology 0.0371968548942256 0.215429980324531 1.82317304051496 0.555555555555556 28.2 28 2 abnormal posterior semicircular canal morphology 0.0371968548942256 0.215429980324531 1.82317304051496 0.555555555555556 28.2 28 2 abnormal artery development 0.0371968548942256 0.215429980324531 1.82317304051496 0.555555555555556 28.2 28 2 decreased cellular sensitivity to ionizing radiation 0.0371968548942256 0.215429980324531 1.82317304051496 0.555555555555556 28.2 28 2 increased neuronal precursor cell number 0.0371968548942256 0.215429980324531 1.82317304051496 0.555555555555556 28.2 28 2 abnormal inguinal fat pad morphology 0.0371968548942256 0.215429980324531 1.82317304051496 0.555555555555556 28.2 28 2 abnormal telomere morphology 0.0371968548942256 0.215429980324531 1.82317304051496 0.555555555555556 28.2 28 2 abnormal ductus venosus valve topology 0.0371968548942256 0.215429980324531 1.82317304051496 0.555555555555556 28.2 28 2 abnormal infrahyoid muscle connection 0.0371968548942256 0.215429980324531 1.82317304051496 0.555555555555556 28.2 28 2 symmetric azygos veins 0.0371968548942256 0.215429980324531 1.82317304051496 0.555555555555556 28.2 28 2 decreased platelet dense granule number 0.0371968548942256 0.215429980324531 1.82317304051496 0.555555555555556 28.2 28 2 pale liver 2.7861108708094e-09 2.61526444948619e-07 1.81824554581086 0.554054054054054 28.2 28 2 increased cellular sensitivity to gamma-irradiation 2.27665795190803e-06 0.000102967030097659 1.81541485736383 0.553191489361702 28.2 28 2 increased mortality induced by gamma-irradiation 0.000214687528550462 0.00450662639045802 1.81059943333899 0.551724137931034 28.2 28 2 blood in lymph vessels 0.000214687528550462 0.00450662639045802 1.81059943333899 0.551724137931034 28.2 28 2 thymus hypoplasia 9.0052340966838e-16 2.98673597540013e-13 1.80731936190178 0.550724637681159 28.2 28 2 decreased muscle cell glucose uptake 0.00220420667971695 0.0280458522547106 1.80494131010981 0.55 28.2 28 2 abnormal definitive hematopoiesis 5.63993436958286e-11 7.19453166376275e-09 1.79964822708896 0.548387096774194 28.2 28 2 decreased IgM level 2.87548622172293e-11 3.76461682975568e-09 1.79310008314564 0.54639175257732 28.2 28 2 abnormal myelopoiesis 7.72467983525657e-06 0.000297061974427301 1.79002443977832 0.545454545454545 28.2 28 2 increased skin papilloma incidence 0.00153019541320776 0.0205749248127259 1.79002443977832 0.545454545454545 28.2 28 2 delayed hepatic development 0.0248564116859146 0.163788937930364 1.79002443977832 0.545454545454545 28.2 28 2 abnormal proximal-distal axis patterning 0.0248564116859146 0.163788937930364 1.79002443977832 0.545454545454545 28.2 28 2 retinal detachment 0.0248564116859146 0.163788937930364 1.79002443977832 0.545454545454545 28.2 28 2 increased number of Howell-Jolly bodies 0.0248564116859146 0.163788937930364 1.79002443977832 0.545454545454545 28.2 28 2 abnormal extraembryonic ectoderm morphology 0.0248564116859146 0.163788937930364 1.79002443977832 0.545454545454545 28.2 28 2 decreased B cell number 6.25900530849311e-22 3.79592502990971e-19 1.78423148042629 0.543689320388349 28.2 28 2 abnormal erythrocyte osmotic lysis 0.000740845087097595 0.0116636212288308 1.76707540849911 0.538461538461538 28.2 28 2 pulmonary edema 0.000740845087097595 0.0116636212288308 1.76707540849911 0.538461538461538 28.2 28 2 abnormal nerve conduction 0.000740845087097595 0.0116636212288308 1.76707540849911 0.538461538461538 28.2 28 2 short premaxilla 0.0167579114269548 0.120652111937916 1.76707540849911 0.538461538461538 28.2 28 2 abnormal grip strength 0.0167579114269548 0.120652111937916 1.76707540849911 0.538461538461538 28.2 28 2 lymphoid hypoplasia 0.0167579114269548 0.120652111937916 1.76707540849911 0.538461538461538 28.2 28 2 abnormal otolith morphology 0.0167579114269548 0.120652111937916 1.76707540849911 0.538461538461538 28.2 28 2 shortened head 0.000516530918648956 0.00886117696647777 1.75805971763942 0.535714285714286 28.2 28 2 premature aging 0.000516530918648956 0.00886117696647777 1.75805971763942 0.535714285714286 28.2 28 2 abnormal spleen marginal zone morphology 0.000360563128276648 0.00672684804992651 1.75024611889436 0.533333333333333 28.2 28 2 abnormal prostate gland morphology 0.0113744452547609 0.0952657662330566 1.75024611889436 0.533333333333333 28.2 28 2 abnormal pericyte morphology 0.0113744452547609 0.0952657662330566 1.75024611889436 0.533333333333333 28.2 28 2 heterochrony 0.0113744452547609 0.0952657662330566 1.75024611889436 0.533333333333333 28.2 28 2 abnormal cell nucleus morphology 9.08389325679414e-06 0.000336982212692797 1.74559120900368 0.531914893617021 28.2 28 2 abnormal embryonic hematopoiesis 0.00025196294769612 0.00507496220562023 1.74340921999243 0.53125 28.2 28 2 impaired hematopoiesis 4.51562450826238e-06 0.000182644162021182 1.73737666213778 0.529411764705882 28.2 28 2 abnormal spleen red pulp morphology 0.000176246957688647 0.0039319668811705 1.73737666213778 0.529411764705882 28.2 28 2 abnormal nervous system development 0.000176246957688647 0.0039319668811705 1.73737666213778 0.529411764705882 28.2 28 2 abnormal interatrial septum morphology 0.00776155308769234 0.0709811150942452 1.73737666213778 0.529411764705882 28.2 28 2 abnormal melanosome morphology 0.00776155308769234 0.0709811150942452 1.73737666213778 0.529411764705882 28.2 28 2 pancytopenia 0.00776155308769234 0.0709811150942452 1.73737666213778 0.529411764705882 28.2 28 2 increased brain size 0.00776155308769234 0.0709811150942452 1.73737666213778 0.529411764705882 28.2 28 2 abnormal cell cytoskeleton morphology 0.00776155308769234 0.0709811150942452 1.73737666213778 0.529411764705882 28.2 28 2 increased grip strength 1.19836450337473e-09 1.29605726180202e-07 1.73101264506035 0.527472527472527 28.2 28 2 embryonic lethality between implantation and somite formation, incomplete penetrance 0.00531906300430956 0.0532441417433402 1.72721656469838 0.526315789473684 28.2 28 2 left pulmonary isomerism 0.00365818603887819 0.0393077225559806 1.7189917239141 0.523809523809524 28.2 28 2 spleen hypoplasia 1.08466326133866e-10 1.31614627442923e-08 1.7189917239141 0.523809523809524 28.2 28 2 abnormal spleen morphology 1.15716884546268e-16 4.11208214726915e-14 1.71629737951925 0.522988505747126 28.2 28 2 abnormal Wolffian duct morphology 0.00252345019642435 0.0310962954946464 1.71219729022274 0.521739130434783 28.2 28 2 abnormal hematopoietic stem cell physiology 0.00252345019642435 0.0310962954946464 1.71219729022274 0.521739130434783 28.2 28 2 thymus atrophy 1.47580381487896e-05 0.000509869720765474 1.70922472548277 0.520833333333333 28.2 28 2 enlarged spleen 2.95730686869594e-26 2.10180023882318e-23 1.70922472548277 0.520833333333333 28.2 28 2 astrocytosis 9.8468629849159e-08 6.99830619285094e-06 1.70828816398936 0.520547945205479 28.2 28 2 liver hypoplasia 7.30492763189675e-06 0.000286157598178633 1.70396557248129 0.519230769230769 28.2 28 2 increased brain weight 0.00120954454355041 0.0172420747970295 1.70162817114729 0.518518518518518 28.2 28 2 abnormal microglial cell morphology 0.000839934550897337 0.012937072417072 1.6974369687553 0.517241379310345 28.2 28 2 lordosis 0.000839934550897337 0.012937072417072 1.6974369687553 0.517241379310345 28.2 28 2 abnormal embryonic erythropoiesis 0.000839934550897337 0.012937072417072 1.6974369687553 0.517241379310345 28.2 28 2 abnormal CD8-positive, alpha-beta T cell physiology 0.000839934550897337 0.012937072417072 1.6974369687553 0.517241379310345 28.2 28 2 increased double-positive T cell number 0.000839934550897337 0.012937072417072 1.6974369687553 0.517241379310345 28.2 28 2 decreased thymus weight 0.000584252820262512 0.00978672653470033 1.69378656667196 0.516129032258065 28.2 28 2 increased osteoblast cell number 0.000407009331644099 0.00752740306665202 1.69057863756841 0.515151515151515 28.2 28 2 hydrops fetalis 2.22105454472078e-07 1.38121829499824e-05 1.68643506247633 0.513888888888889 28.2 28 2 increased erythroid progenitor cell number 0.000198283067158454 0.00423372643396269 1.68520318880031 0.513513513513513 28.2 28 2 small liver 7.83117682277294e-08 5.64639198453556e-06 1.68292896047534 0.512820512820513 28.2 28 2 impaired macrophage phagocytosis 6.7954492208793e-05 0.0017887491996759 1.67901517219517 0.511627906976744 28.2 28 2 increased sarcoma incidence 2.34605376176914e-05 0.000720470213876633 1.67434258822802 0.510204081632653 28.2 28 2 increased double-negative T cell number 2.84103097542869e-06 0.000122905470458763 1.66775501083171 0.508196721311475 28.2 28 2 decreased lymphocyte cell number 1.39069399898374e-11 1.97677218426974e-09 1.6664941073457 0.5078125 28.2 28 2 decreased hemoglobin content 2.74271112261645e-12 4.54832927833894e-10 1.65249301119015 0.50354609929078 28.2 28 2 pallor 7.92619082215074e-15 1.97163996701e-12 1.65023205495754 0.502857142857143 28.2 28 2 decreased cell proliferation 1.42146526938425e-15 3.92877206399258e-13 1.64972522693083 0.502702702702703 28.2 28 2 abnormal spleen white pulp morphology 0.000151483159390992 0.00353816299516519 1.64085573646346 0.5 28.2 28 2 prolonged QRS complex duration 0.00190255816845187 0.0246490283542917 1.64085573646346 0.5 28.2 28 2 irregularly shaped pupil 0.026856005126429 0.17176433587576 1.64085573646346 0.5 28.2 28 2 abnormal antigen presentation 0.026856005126429 0.17176433587576 1.64085573646346 0.5 28.2 28 2 abnormal kidney medulla morphology 0.026856005126429 0.17176433587576 1.64085573646346 0.5 28.2 28 2 amyloid beta deposits 0.026856005126429 0.17176433587576 1.64085573646346 0.5 28.2 28 2 decreased CNS synapse formation 0.026856005126429 0.17176433587576 1.64085573646346 0.5 28.2 28 2 abnormal iris pigmentation 0.026856005126429 0.17176433587576 1.64085573646346 0.5 28.2 28 2 pulmonary alveolar hemorrhage 0.026856005126429 0.17176433587576 1.64085573646346 0.5 28.2 28 2 abnormal vitelline vein topology 0.026856005126429 0.17176433587576 1.64085573646346 0.5 28.2 28 2 decreased response to antigen 0.026856005126429 0.17176433587576 1.64085573646346 0.5 28.2 28 2 decreased hematocrit 2.12762666852115e-12 3.64998023306645e-10 1.64085573646346 0.5 28.2 28 2 oxidative stress 3.35370158715723e-08 2.60697896814175e-06 1.64085573646346 0.5 28.2 28 2 abnormal placenta vasculature 2.56549182459341e-05 0.00076887480887664 1.64085573646346 0.5 28.2 28 2 kinked neural tube 2.56549182459341e-05 0.00076887480887664 1.64085573646346 0.5 28.2 28 2 abnormal allantois morphology 7.4281530198061e-05 0.0019348199619652 1.64085573646346 0.5 28.2 28 2 increased bone marrow cell number 0.000310101461882841 0.00600293685940519 1.64085573646346 0.5 28.2 28 2 decreased hair follicle number 0.000310101461882841 0.00600293685940519 1.64085573646346 0.5 28.2 28 2 decreased neuron apoptosis 0.000310101461882841 0.00600293685940519 1.64085573646346 0.5 28.2 28 2 increased thymocyte apoptosis 0.00274943853524392 0.033690780080883 1.64085573646346 0.5 28.2 28 2 small lymph nodes 0.0039829398667472 0.0417919909993932 1.64085573646346 0.5 28.2 28 2 increased hemangiosarcoma incidence 0.0039829398667472 0.0417919909993932 1.64085573646346 0.5 28.2 28 2 abnormal abdominal fat pad morphology 0.00578617666454862 0.056889780446896 1.64085573646346 0.5 28.2 28 2 abnormal lysosome physiology 0.00578617666454862 0.056889780446896 1.64085573646346 0.5 28.2 28 2 abnormal vascular branching morphogenesis 0.00578617666454862 0.056889780446896 1.64085573646346 0.5 28.2 28 2 abnormal sperm midpiece morphology 0.00578617666454862 0.056889780446896 1.64085573646346 0.5 28.2 28 2 increased adenoma incidence 0.00578617666454862 0.056889780446896 1.64085573646346 0.5 28.2 28 2 spleen atrophy 0.00843391932890214 0.075601348939258 1.64085573646346 0.5 28.2 28 2 absent ductus venosus valve 0.00843391932890214 0.075601348939258 1.64085573646346 0.5 28.2 28 2 myocarditis 0.040048155284866 0.225765940962159 1.64085573646346 0.5 28.2 28 2 abnormal embryonic growth/weight/body size 0.040048155284866 0.225765940962159 1.64085573646346 0.5 28.2 28 2 loss of dopaminergic neurons 0.040048155284866 0.225765940962159 1.64085573646346 0.5 28.2 28 2 delayed somite formation 0.040048155284866 0.225765940962159 1.64085573646346 0.5 28.2 28 2 abnormal rostral-caudal body axis extension 0.040048155284866 0.225765940962159 1.64085573646346 0.5 28.2 28 2 abnormal B cell proliferation 0.040048155284866 0.225765940962159 1.64085573646346 0.5 28.2 28 2 abnormal prostate gland epithelium morphology 0.0603473024529522 0.271699393396776 1.64085573646346 0.5 28.2 28 2 abnormal tibialis anterior morphology 0.0603473024529522 0.271699393396776 1.64085573646346 0.5 28.2 28 2 abnormal hypaxial muscle morphology 0.0603473024529522 0.271699393396776 1.64085573646346 0.5 28.2 28 2 increased atrioventricular cushion size 0.0603473024529522 0.271699393396776 1.64085573646346 0.5 28.2 28 2 abnormal pillar cell morphology 0.0603473024529522 0.271699393396776 1.64085573646346 0.5 28.2 28 2 increased platelet aggregation 0.0603473024529522 0.271699393396776 1.64085573646346 0.5 28.2 28 2 increased T-helper 17 cell number 0.0603473024529522 0.271699393396776 1.64085573646346 0.5 28.2 28 2 abnormal left subclavian artery morphology 0.0603473024529522 0.271699393396776 1.64085573646346 0.5 28.2 28 2 thick aortic valve cusps 0.0603473024529522 0.271699393396776 1.64085573646346 0.5 28.2 28 2 abnormal adaptive thermogenesis 0.0603473024529522 0.271699393396776 1.64085573646346 0.5 28.2 28 2 increased tumor incidence 9.40590491174283e-11 1.16985942339801e-08 1.64085573646346 0.5 28.2 28 2 absent mesoderm 6.269524766614e-06 0.000249527085711237 1.64085573646346 0.5 28.2 28 2 abnormal lysosome morphology 0.000444431105172309 0.00804822509574121 1.64085573646346 0.5 28.2 28 2 scoliosis 0.000916542692828899 0.0135305634920587 1.64085573646346 0.5 28.2 28 2 increased fibroblast apoptosis 0.000916542692828899 0.0135305634920587 1.64085573646346 0.5 28.2 28 2 abnormal fat pad morphology 0.00131930597351803 0.0183339307772408 1.64085573646346 0.5 28.2 28 2 abnormal cellular respiration 0.00131930597351803 0.0183339307772408 1.64085573646346 0.5 28.2 28 2 abnormal thymus cortex morphology 0.012342539301166 0.0986813127423095 1.64085573646346 0.5 28.2 28 2 abnormal thymus medulla morphology 0.012342539301166 0.0986813127423095 1.64085573646346 0.5 28.2 28 2 abnormal bile duct morphology 0.012342539301166 0.0986813127423095 1.64085573646346 0.5 28.2 28 2 darkened coat color 0.012342539301166 0.0986813127423095 1.64085573646346 0.5 28.2 28 2 jerky movement 0.012342539301166 0.0986813127423095 1.64085573646346 0.5 28.2 28 2 increased effector memory CD8-positive, alpha-beta T cell number 0.012342539301166 0.0986813127423095 1.64085573646346 0.5 28.2 28 2 blepharitis 0.018150966308028 0.12881748556696 1.64085573646346 0.5 28.2 28 2 decreased liver cholesterol level 0.018150966308028 0.12881748556696 1.64085573646346 0.5 28.2 28 2 decreased bone marrow cell number 1.17453904974146e-06 5.9728551059622e-05 1.6183782606215 0.493150684931507 28.2 28 2 abnormal CD4-positive, alpha-beta T cell physiology 1.66516917678897e-06 7.74225855563097e-05 1.61774509228792 0.492957746478873 28.2 28 2 microcephaly 2.36150509351181e-06 0.000104897212859118 1.6170752185437 0.492753623188406 28.2 28 2 increased lymphocyte cell number 2.36150509351181e-06 0.000104897212859118 1.6170752185437 0.492753623188406 28.2 28 2 increased macrophage cell number 1.93675953986541e-05 0.000621637336182609 1.61206879371849 0.491228070175439 28.2 28 2 decreased T cell number 9.56821757385087e-13 1.76303268258919e-10 1.61028078485234 0.490683229813665 28.2 28 2 decreased bone trabecula number 0.000113441455172413 0.00280511597247297 1.60594391228339 0.48936170212766 28.2 28 2 delayed endochondral bone ossification 0.000231215068974001 0.00477300816657947 1.60269630073175 0.488372093023256 28.2 28 2 increased autoantibody level 0.000473000727369631 0.00849522967026684 1.59878251245158 0.487179487179487 28.2 28 2 failure of heart looping 0.000473000727369631 0.00849522967026684 1.59878251245158 0.487179487179487 28.2 28 2 increased spleen weight 3.69312406389392e-09 3.4024615218282e-07 1.59729319478744 0.486725663716814 28.2 28 2 increased granulocyte number 1.77427998112639e-06 8.09820450101267e-05 1.59650828412661 0.486486486486487 28.2 28 2 abnormal chromosome morphology 0.000677623983290697 0.0110530469405614 1.59650828412661 0.486486486486487 28.2 28 2 increased carcinoma incidence 0.000971971246344424 0.0140978336751123 1.59397414399308 0.485714285714286 28.2 28 2 decreased glycogen level 0.000971971246344424 0.0140978336751123 1.59397414399308 0.485714285714286 28.2 28 2 abnormal hippocampus pyramidal cell morphology 0.000971971246344424 0.0140978336751123 1.59397414399308 0.485714285714286 28.2 28 2 abnormal humoral immune response 1.46813455470355e-08 1.25930507062934e-06 1.59397414399308 0.485714285714286 28.2 28 2 decreased brown adipose tissue amount 0.00139610350335577 0.0191867815723618 1.59113283535851 0.484848484848485 28.2 28 2 osteopetrosis 0.00200841830469507 0.0256860695780411 1.58792490625496 0.483870967741935 28.2 28 2 abnormal capillary morphology 0.00200841830469507 0.0256860695780411 1.58792490625496 0.483870967741935 28.2 28 2 inner cell mass degeneration 0.00200841830469507 0.0256860695780411 1.58792490625496 0.483870967741935 28.2 28 2 liver inflammation 1.96435212830376e-09 1.89589189884723e-07 1.58616054524801 0.483333333333333 28.2 28 2 increased erythrocyte cell number 2.05027742429044e-05 0.000649689820754456 1.58616054524801 0.483333333333333 28.2 28 2 decreased trophoblast giant cell number 0.00289434021150276 0.0337181294398785 1.58427450417162 0.482758620689655 28.2 28 2 polychromatophilia 0.00289434021150276 0.0337181294398785 1.58427450417162 0.482758620689655 28.2 28 2 abnormal lung development 4.66572428686698e-07 2.66804348588083e-05 1.58294318105887 0.482352941176471 28.2 28 2 abnormal apoptosis 5.88748641403647e-05 0.00159702792409854 1.58008330177963 0.481481481481481 28.2 28 2 abnormal fetal cardiomyocyte proliferation 0.00417934009895933 0.0431373796521217 1.58008330177963 0.481481481481481 28.2 28 2 abnormal eye muscle morphology 0.00417934009895933 0.0431373796521217 1.58008330177963 0.481481481481481 28.2 28 2 abnormal nervous system morphology 1.32115442181827e-06 6.5727432485459e-05 1.57854475912941 0.481012658227848 28.2 28 2 abnormal extraembryonic tissue morphology 4.36197460916487e-08 3.33858825855311e-06 1.57650845268058 0.480392156862745 28.2 28 2 increased cellular sensitivity to ionizing radiation 0.00604859961035623 0.0587730137920356 1.57522150700492 0.48 28.2 28 2 abnormal cochlear outer hair cell morphology 0.00604859961035623 0.0587730137920356 1.57522150700492 0.48 28.2 28 2 small heart 0.00016989402941424 0.00388164947962375 1.57248674744415 0.479166666666667 28.2 28 2 embryonic lethality between implantation and placentation, complete penetrance 0.000242191913476263 0.0049321815491703 1.56951418270418 0.478260869565217 28.2 28 2 abnormal cardiovascular development 0.00877700926032921 0.0782538012009639 1.56951418270418 0.478260869565217 28.2 28 2 decreased erythrocyte cell number 1.87140446270136e-11 2.58617700053869e-09 1.56769656350012 0.477707006369427 28.2 28 2 internal hemorrhage 1.06590409415681e-05 0.000389917122678686 1.5673845840845 0.477611940298507 28.2 28 2 abnormal dendritic cell physiology 3.23551272266576e-08 2.55502790400986e-06 1.56418023475956 0.476635514018692 28.2 28 2 increased T cell proliferation 3.23551272266576e-08 2.55502790400986e-06 1.56418023475956 0.476635514018692 28.2 28 2 abnormal scapula morphology 0.0127754950471057 0.0986813127423095 1.56271974901282 0.476190476190476 28.2 28 2 abnormal erythrocyte physiology 0.0127754950471057 0.0986813127423095 1.56271974901282 0.476190476190476 28.2 28 2 abnormal clavicle morphology 0.0127754950471057 0.0986813127423095 1.56271974901282 0.476190476190476 28.2 28 2 abnormal tumor vascularization 0.0127754950471057 0.0986813127423095 1.56271974901282 0.476190476190476 28.2 28 2 absent segment of posterior cerebral artery 0.0127754950471057 0.0986813127423095 1.56271974901282 0.476190476190476 28.2 28 2 increased bone ossification 0.0127754950471057 0.0986813127423095 1.56271974901282 0.476190476190476 28.2 28 2 abnormal developmental patterning 1.38035367663449e-06 6.79926687253129e-05 1.56081399322134 0.475609756097561 28.2 28 2 decreased circulating serum albumin level 1.28158670927755e-07 8.73410120363809e-06 1.55798423462187 0.474747474747475 28.2 28 2 increased embryonic tissue cell apoptosis 2.75931976342244e-06 0.000120417682658128 1.55670928843969 0.474358974358974 28.2 28 2 abnormal triglyceride level 0.0186636679683368 0.130839184057172 1.55449490822854 0.473684210526316 28.2 28 2 abnormal stationary movement 0.0186636679683368 0.130839184057172 1.55449490822854 0.473684210526316 28.2 28 2 increased liver adenoma incidence 0.0186636679683368 0.130839184057172 1.55449490822854 0.473684210526316 28.2 28 2 abnormal T-helper 2 physiology 8.69609670123267e-05 0.00220730005554248 1.55135451447454 0.472727272727273 28.2 28 2 pericardial edema 1.5641614966062e-05 0.000532993386686015 1.54433481078914 0.470588235294118 28.2 28 2 increased lung adenocarcinoma incidence 0.00017564219322742 0.0039319668811705 1.54433481078914 0.470588235294118 28.2 28 2 abnormal adipose tissue morphology 0.0273860002816597 0.173119887422182 1.54433481078914 0.470588235294118 28.2 28 2 enhanced behavioral response to cocaine 0.0273860002816597 0.173119887422182 1.54433481078914 0.470588235294118 28.2 28 2 increased hepatoma incidence 0.0273860002816597 0.173119887422182 1.54433481078914 0.470588235294118 28.2 28 2 abnormal vascular development 2.21443544555407e-05 0.000697266857065284 1.54140993425355 0.46969696969697 28.2 28 2 decreased caudal vertebrae number 3.13582566867099e-05 0.000934175610876536 1.53830225293449 0.46875 28.2 28 2 neonatal lethality 0.00297183796222404 0.0337181294398785 1.53830225293449 0.46875 28.2 28 2 pancreatic islet hyperplasia 0.00297183796222404 0.0337181294398785 1.53830225293449 0.46875 28.2 28 2 abnormal auditory brainstem response waveform shape 0.00297183796222404 0.0337181294398785 1.53830225293449 0.46875 28.2 28 2 pericardial effusion 4.44175065243125e-05 0.00127732424831477 1.53499407604646 0.467741935483871 28.2 28 2 abnormal cell migration 0.000506186104768486 0.00886117696647777 1.53146535403256 0.466666666666667 28.2 28 2 lethality at weaning, complete penetrance 0.000506186104768486 0.00886117696647777 1.53146535403256 0.466666666666667 28.2 28 2 intracranial hemorrhage 6.29326633264962e-05 0.00167536644093921 1.53146535403256 0.466666666666667 28.2 28 2 abnormal microglial cell physiology 0.0042724951697394 0.0438261102462959 1.53146535403256 0.466666666666667 28.2 28 2 decreased hepatocyte number 0.0404023700141386 0.225765940962159 1.53146535403256 0.466666666666667 28.2 28 2 abnormal placenta size 0.0404023700141386 0.225765940962159 1.53146535403256 0.466666666666667 28.2 28 2 abnormal trophectoderm morphology 0.0404023700141386 0.225765940962159 1.53146535403256 0.466666666666667 28.2 28 2 abnormal olfactory nerve morphology 0.0404023700141386 0.225765940962159 1.53146535403256 0.466666666666667 28.2 28 2 immune system phenotype 0.0404023700141386 0.225765940962159 1.53146535403256 0.466666666666667 28.2 28 2 abnormal dendritic cell morphology 0.0404023700141386 0.225765940962159 1.53146535403256 0.466666666666667 28.2 28 2 bicuspid aortic valve 0.0404023700141386 0.225765940962159 1.53146535403256 0.466666666666667 28.2 28 2 decreased embryo size 2.60618547534447e-29 2.59315454796774e-26 1.53100765368766 0.46652719665272 28.2 28 2 embryonic lethality between implantation and somite formation, complete penetrance 1.36240328615294e-15 3.92877206399258e-13 1.52700044046396 0.46530612244898 28.2 28 2 abnormal vasculogenesis 0.000721223139654096 0.0115425908965169 1.52637742926834 0.465116279069767 28.2 28 2 increased mean corpuscular hemoglobin 3.81669642338109e-07 2.23388996544952e-05 1.52483563388524 0.464646464646465 28.2 28 2 lymphoid hyperplasia 0.00615255110539916 0.0592049163430576 1.5236517552875 0.464285714285714 28.2 28 2 perimembraneous ventricular septal defect 2.26644687930227e-05 0.000709155548712502 1.52195314686466 0.463768115942029 28.2 28 2 decreased tumor growth/size 0.000179320078659655 0.00393531288995927 1.5193108670958 0.462962962962963 28.2 28 2 lethargy 1.06544483472502e-06 5.57956637132312e-05 1.51735046597696 0.462365591397849 28.2 28 2 impaired macrophage chemotaxis 0.00146730298843331 0.0199311123653369 1.51463606442781 0.461538461538462 28.2 28 2 increased hepatocyte apoptosis 0.00146730298843331 0.0199311123653369 1.51463606442781 0.461538461538462 28.2 28 2 decreased trabecular bone volume 0.00146730298843331 0.0199311123653369 1.51463606442781 0.461538461538462 28.2 28 2 ventricular hypoplasia 0.00887645196045249 0.0785771325680625 1.51463606442781 0.461538461538462 28.2 28 2 abnormal stomach morphology 0.00887645196045249 0.0785771325680625 1.51463606442781 0.461538461538462 28.2 28 2 decreased circulating glycerol level 0.00887645196045249 0.0785771325680625 1.51463606442781 0.461538461538462 28.2 28 2 excessive scratching 0.0600112214487899 0.271699393396776 1.51463606442781 0.461538461538462 28.2 28 2 abnormal lung interstitium morphology 0.0600112214487899 0.271699393396776 1.51463606442781 0.461538461538462 28.2 28 2 abnormal telomere length 0.0600112214487899 0.271699393396776 1.51463606442781 0.461538461538462 28.2 28 2 increased circulating ammonia level 0.0600112214487899 0.271699393396776 1.51463606442781 0.461538461538462 28.2 28 2 small pituitary gland 0.0600112214487899 0.271699393396776 1.51463606442781 0.461538461538462 28.2 28 2 increased circulating thyroxine level 0.0600112214487899 0.271699393396776 1.51463606442781 0.461538461538462 28.2 28 2 abnormal liver physiology 5.47333173893866e-07 3.05953094395728e-05 1.50958727754638 0.46 28.2 28 2 abnormal interventricular septum morphology 0.0003610187797649 0.00672684804992651 1.50958727754638 0.46 28.2 28 2 short stride length 0.0003610187797649 0.00672684804992651 1.50958727754638 0.46 28.2 28 2 anemia 4.27118156237875e-13 8.49965130913372e-11 1.50865408944982 0.459715639810427 28.2 28 2 increased trabecular bone volume 0.00209538417993289 0.0267295802440157 1.50781337945291 0.459459459459459 28.2 28 2 embryonic growth arrest 5.83755124421268e-14 1.32008261090719e-11 1.50471486749924 0.458515283842795 28.2 28 2 increased stereotypic behavior 0.012833529516437 0.0986813127423095 1.50411775842484 0.458333333333333 28.2 28 2 abnormal vasodilation 0.012833529516437 0.0986813127423095 1.50411775842484 0.458333333333333 28.2 28 2 prolonged QT interval 0.012833529516437 0.0986813127423095 1.50411775842484 0.458333333333333 28.2 28 2 double outlet right ventricle 2.81016019242135e-07 1.72599345151805e-05 1.50283983339644 0.457943925233645 28.2 28 2 lethality throughout fetal growth and development, complete penetrance 8.73385796858706e-12 1.40164333528131e-09 1.50267841128759 0.457894736842105 28.2 28 2 increased red blood cell distribution width 0.00299498039447494 0.0337869103458341 1.50021095905231 0.457142857142857 28.2 28 2 increased neuron apoptosis 8.30124446471394e-06 0.000312868872817817 1.49905338886785 0.45679012345679 28.2 28 2 abnormal immune system morphology 0.000727941225453957 0.0116073961430559 1.4981726289449 0.456521739130435 28.2 28 2 abnormal craniofacial bone morphology 0.000181143045588075 0.00393531288995927 1.4969210227386 0.456140350877193 28.2 28 2 decreased brain weight 0.000181143045588075 0.00393531288995927 1.4969210227386 0.456140350877193 28.2 28 2 increased hepatocellular carcinoma incidence 0.000181143045588075 0.00393531288995927 1.4969210227386 0.456140350877193 28.2 28 2 decreased mean corpuscular hemoglobin 4.57690527721424e-05 0.00129375589512164 1.49607434795198 0.455882352941176 28.2 28 2 abnormal placenta morphology 1.1687460929214e-05 0.000421341435672753 1.49546345601733 0.455696202531646 28.2 28 2 cochlear hair cell degeneration 0.00103431478541739 0.0148720117267385 1.4916870331486 0.454545454545455 28.2 28 2 abnormal QRS complex 0.00428495001128093 0.043863428613421 1.4916870331486 0.454545454545455 28.2 28 2 intracerebral hemorrhage 0.01859992703257 0.130839184057172 1.4916870331486 0.454545454545455 28.2 28 2 testis hypoplasia 0.01859992703257 0.130839184057172 1.4916870331486 0.454545454545455 28.2 28 2 abnormal cerebral cortex pyramidal cell morphology 0.01859992703257 0.130839184057172 1.4916870331486 0.454545454545455 28.2 28 2 increased circulating creatine kinase level 0.01859992703257 0.130839184057172 1.4916870331486 0.454545454545455 28.2 28 2 decreased atrioventricular cushion size 0.0899230447588168 0.360350439607561 1.4916870331486 0.454545454545455 28.2 28 2 abnormal large intestine morphology 0.0899230447588168 0.360350439607561 1.4916870331486 0.454545454545455 28.2 28 2 abnormal vestibular ganglion morphology 0.0899230447588168 0.360350439607561 1.4916870331486 0.454545454545455 28.2 28 2 patent ductus arteriosus 0.0899230447588168 0.360350439607561 1.4916870331486 0.454545454545455 28.2 28 2 loss of cortex neurons 0.0899230447588168 0.360350439607561 1.4916870331486 0.454545454545455 28.2 28 2 abnormal pituitary gland development 0.0899230447588168 0.360350439607561 1.4916870331486 0.454545454545455 28.2 28 2 abnormal dorsal-ventral polarity of the somites 0.0899230447588168 0.360350439607561 1.4916870331486 0.454545454545455 28.2 28 2 abnormal platelet aggregation 0.0899230447588168 0.360350439607561 1.4916870331486 0.454545454545455 28.2 28 2 decreased palatine bone horizontal plate size 0.0899230447588168 0.360350439607561 1.4916870331486 0.454545454545455 28.2 28 2 common atrioventricular valve 0.0899230447588168 0.360350439607561 1.4916870331486 0.454545454545455 28.2 28 2 abnormal dendritic cell chemotaxis 0.0899230447588168 0.360350439607561 1.4916870331486 0.454545454545455 28.2 28 2 abnormal pulmonary alveolar sac morphology 0.0899230447588168 0.360350439607561 1.4916870331486 0.454545454545455 28.2 28 2 chylous ascites 0.0899230447588168 0.360350439607561 1.4916870331486 0.454545454545455 28.2 28 2 hypolactation 0.0899230447588168 0.360350439607561 1.4916870331486 0.454545454545455 28.2 28 2 thin hypoglossal nerve 0.0899230447588168 0.360350439607561 1.4916870331486 0.454545454545455 28.2 28 2 reduced sympathetic cervical ganglion size 0.0899230447588168 0.360350439607561 1.4916870331486 0.454545454545455 28.2 28 2 increased B cell number 1.45371849218977e-07 9.64299933152547e-06 1.48658724841989 0.452991452991453 28.2 28 2 abnormal cytotoxic T cell physiology 0.00147029512323189 0.0199311123653369 1.48458376156218 0.452380952380952 28.2 28 2 prenatal lethality 0.000128524209131165 0.00308041463048325 1.48206324583796 0.451612903225806 28.2 28 2 increased eosinophil cell number 0.000128524209131165 0.00308041463048325 1.48206324583796 0.451612903225806 28.2 28 2 autoimmune response 0.00613702905859942 0.059169999159946 1.48206324583796 0.451612903225806 28.2 28 2 decreased double-negative T cell number 0.00613702905859942 0.059169999159946 1.48206324583796 0.451612903225806 28.2 28 2 abnormal T cell proliferation 0.00613702905859942 0.059169999159946 1.48206324583796 0.451612903225806 28.2 28 2 preaxial polydactyly 0.00613702905859942 0.059169999159946 1.48206324583796 0.451612903225806 28.2 28 2 abnormal gluconeogenesis 0.000513292404420686 0.00886117696647777 1.47998752700626 0.450980392156863 28.2 28 2 small lung 0.000513292404420686 0.00886117696647777 1.47998752700626 0.450980392156863 28.2 28 2 decreased IgG level 3.9982394251246e-07 2.31293501627847e-05 1.47824841122834 0.45045045045045 28.2 28 2 abnormal circulating enzyme level 0.0270334623096924 0.17176433587576 1.47677016281711 0.45 28.2 28 2 absent placental labyrinth 0.0270334623096924 0.17176433587576 1.47677016281711 0.45 28.2 28 2 dilated vasculature 0.0270334623096924 0.17176433587576 1.47677016281711 0.45 28.2 28 2 abnormal response to tactile stimuli 0.0270334623096924 0.17176433587576 1.47677016281711 0.45 28.2 28 2 abnormal induced retinal neovascularization 0.0270334623096924 0.17176433587576 1.47677016281711 0.45 28.2 28 2 abnormal sperm mitochondrial sheath morphology 0.0270334623096924 0.17176433587576 1.47677016281711 0.45 28.2 28 2 abnormal neuron proliferation 0.0270334623096924 0.17176433587576 1.47677016281711 0.45 28.2 28 2 abnormal cornea morphology 2.31762892852572e-05 0.000716161734125183 1.47256284041593 0.448717948717949 28.2 28 2 thrombocytosis 0.000255853519393661 0.00511193276700187 1.47111203958793 0.448275862068966 28.2 28 2 decreased granulocyte number 0.00879984745668995 0.0783170681521154 1.47111203958793 0.448275862068966 28.2 28 2 persistence of hyaloid vascular system 0.00297532840685561 0.0337181294398785 1.46813407999362 0.447368421052632 28.2 28 2 pale yolk sac 1.64377248433133e-05 0.000548843497285127 1.4629316204614 0.44578313253012 28.2 28 2 embryonic lethality, complete penetrance 5.60442942438582e-17 2.14477202971688e-14 1.4608245428076 0.445141065830721 28.2 28 2 abnormal cell adhesion 0.0005093410846409 0.00886117696647777 1.45853843241197 0.444444444444444 28.2 28 2 axon degeneration 0.0005093410846409 0.00886117696647777 1.45853843241197 0.444444444444444 28.2 28 2 decreased platelet aggregation 0.0005093410846409 0.00886117696647777 1.45853843241197 0.444444444444444 28.2 28 2 abnormal trigeminal nerve morphology 0.012634141449647 0.0986813127423095 1.45853843241197 0.444444444444444 28.2 28 2 decreased circulating fructosamine level 0.012634141449647 0.0986813127423095 1.45853843241197 0.444444444444444 28.2 28 2 decreased bone ossification 0.012634141449647 0.0986813127423095 1.45853843241197 0.444444444444444 28.2 28 2 abnormal retinal blood vessel morphology 0.00423578003298246 0.0435392679010077 1.45853843241197 0.444444444444444 28.2 28 2 abnormal megakaryocyte differentiation 0.0394207690660546 0.224906337274796 1.45853843241197 0.444444444444444 28.2 28 2 abnormal mammary gland morphology 0.0394207690660546 0.224906337274796 1.45853843241197 0.444444444444444 28.2 28 2 abnormal retinal rod cell morphology 0.0394207690660546 0.224906337274796 1.45853843241197 0.444444444444444 28.2 28 2 eye inflammation 0.0394207690660546 0.224906337274796 1.45853843241197 0.444444444444444 28.2 28 2 abnormal glycogen homeostasis 0.0394207690660546 0.224906337274796 1.45853843241197 0.444444444444444 28.2 28 2 decreased lactate dehydrogenase level 0.0394207690660546 0.224906337274796 1.45853843241197 0.444444444444444 28.2 28 2 small thoracic cage 0.0394207690660546 0.224906337274796 1.45853843241197 0.444444444444444 28.2 28 2 increased gastrointestinal tumor incidence 0.0394207690660546 0.224906337274796 1.45853843241197 0.444444444444444 28.2 28 2 increased effector memory CD4-positive, alpha-beta T cell number 0.0394207690660546 0.224906337274796 1.45853843241197 0.444444444444444 28.2 28 2 abnormal aerobic respiration 0.0394207690660546 0.224906337274796 1.45853843241197 0.444444444444444 28.2 28 2 embryonic lethality between somite formation and embryo turning, complete penetrance 9.01911834169459e-05 0.00227767074872744 1.45332936658192 0.442857142857143 28.2 28 2 abnormal NK cell physiology 0.000253438344717538 0.00508409582649094 1.45256081588569 0.442622950819672 28.2 28 2 decreased IgA level 0.000718628508257249 0.0115425908965169 1.45152622840998 0.442307692307692 28.2 28 2 obese 4.52937149751211e-05 0.00128763561143559 1.44906740363007 0.441558441558442 28.2 28 2 thrombocytopenia 2.68851888107827e-08 2.19268548087941e-06 1.44847954667119 0.441379310344828 28.2 28 2 enlarged liver sinusoidal spaces 0.00603345564191926 0.0587730137920356 1.44781388511482 0.441176470588235 28.2 28 2 embryonic lethality during organogenesis, complete penetrance 9.24136100570304e-28 7.66262850056211e-25 1.44746916752312 0.441071428571429 28.2 28 2 increased monocyte cell number 4.16456806679153e-06 0.000170909348375976 1.44395304808785 0.44 28.2 28 2 small spleen 1.15038944664069e-05 0.000417750912192513 1.4425105375503 0.43956043956044 28.2 28 2 liver fibrosis 0.00292272451392513 0.0337181294398785 1.44075137835816 0.439024390243902 28.2 28 2 increased bone trabecula number 0.00292272451392513 0.0337181294398785 1.44075137835816 0.439024390243902 28.2 28 2 decreased susceptibility to induced arthritis 0.000501505114007145 0.00886117696647777 1.43934713724865 0.43859649122807 28.2 28 2 impaired natural killer cell mediated cytotoxicity 0.000501505114007145 0.00886117696647777 1.43934713724865 0.43859649122807 28.2 28 2 overriding aortic valve 0.00143027626150663 0.0196022710771226 1.43574876940553 0.4375 28.2 28 2 decreased susceptibility to parasitic infection 0.00859884435578026 0.0768029635009099 1.43574876940553 0.4375 28.2 28 2 disorganized yolk sac vascular plexus 0.0577090173411134 0.265099133215179 1.43574876940553 0.4375 28.2 28 2 intraventricular hemorrhage 0.0577090173411134 0.265099133215179 1.43574876940553 0.4375 28.2 28 2 abnormal epicardium morphology 0.0577090173411134 0.265099133215179 1.43574876940553 0.4375 28.2 28 2 abnormal level of surface class II molecules 0.0577090173411134 0.265099133215179 1.43574876940553 0.4375 28.2 28 2 kidney degeneration 0.0577090173411134 0.265099133215179 1.43574876940553 0.4375 28.2 28 2 abnormal thoracic cage shape 0.0577090173411134 0.265099133215179 1.43574876940553 0.4375 28.2 28 2 decreased fibroblast apoptosis 0.0577090173411134 0.265099133215179 1.43574876940553 0.4375 28.2 28 2 abnormal rostral-caudal axis patterning 0.000705254694660358 0.0113916951491405 1.43201955182266 0.436363636363636 28.2 28 2 decreased circulating total protein level 0.000705254694660358 0.0113916951491405 1.43201955182266 0.436363636363636 28.2 28 2 abnormal response to injury 0.00414062077563647 0.0429158090808155 1.43048961640404 0.435897435897436 28.2 28 2 abnormal innervation pattern to muscle 0.0261560176266014 0.169877529624467 1.42683107518562 0.434782608695652 28.2 28 2 abnormal postnatal growth 0.0261560176266014 0.169877529624467 1.42683107518562 0.434782608695652 28.2 28 2 increased susceptibility to age related obesity 0.0261560176266014 0.169877529624467 1.42683107518562 0.434782608695652 28.2 28 2 dilated heart 0.0261560176266014 0.169877529624467 1.42683107518562 0.434782608695652 28.2 28 2 abnormal hepatocyte physiology 0.0261560176266014 0.169877529624467 1.42683107518562 0.434782608695652 28.2 28 2 abnormal vertebral artery topology 0.0261560176266014 0.169877529624467 1.42683107518562 0.434782608695652 28.2 28 2 abnormal vitelline vasculature morphology 1.46625673730446e-06 6.94726406484733e-05 1.42683107518562 0.434782608695652 28.2 28 2 abnormal glucose homeostasis 1.7465279107515e-09 1.81020340749765e-07 1.42447915583092 0.434065934065934 28.2 28 2 atrioventricular septal defect 0.000991533801734504 0.014339769371015 1.42413894108149 0.433962264150943 28.2 28 2 gastrointestinal hemorrhage 0.0122619403820051 0.0986813127423095 1.42207497160167 0.433333333333333 28.2 28 2 abnormal optic cup morphology 0.0122619403820051 0.0986813127423095 1.42207497160167 0.433333333333333 28.2 28 2 decreased T cell proliferation 6.89786576609445e-08 5.04660032151763e-06 1.41911847477921 0.432432432432432 28.2 28 2 abnormal angiogenesis 0.000121806014153092 0.00295602400200797 1.41911847477921 0.432432432432432 28.2 28 2 abnormal branching of the mammary ductal tree 0.00586655782578214 0.0575663218604855 1.41911847477921 0.432432432432432 28.2 28 2 insulin resistance 3.70034154320679e-07 2.21797580451251e-05 1.41710268149117 0.431818181818182 28.2 28 2 muscular atrophy 0.00284534714375595 0.0337181294398785 1.41710268149117 0.431818181818182 28.2 28 2 decreased macrophage cell number 0.00284534714375595 0.0337181294398785 1.41710268149117 0.431818181818182 28.2 28 2 decreased blood urea nitrogen level 0.00284534714375595 0.0337181294398785 1.41710268149117 0.431818181818182 28.2 28 2 failure of chorioallantoic fusion 0.00139360500349118 0.0191867815723618 1.41564024322338 0.431372549019608 28.2 28 2 abnormal inflammatory response 0.000170090369157382 0.00388164947962375 1.41295910639909 0.430555555555556 28.2 28 2 hunched posture 8.5103497041444e-05 0.00219373004031702 1.41238215290526 0.430379746835443 28.2 28 2 abnormal somite development 8.5103497041444e-05 0.00219373004031702 1.41238215290526 0.430379746835443 28.2 28 2 disheveled coat 0.00401204655694509 0.0418447203790395 1.40644777411154 0.428571428571429 28.2 28 2 skin edema 0.00401204655694509 0.0418447203790395 1.40644777411154 0.428571428571429 28.2 28 2 thick pulmonary interalveolar septum 0.00831231207750247 0.0750521825509525 1.40644777411154 0.428571428571429 28.2 28 2 abnormal embryonic epiblast morphology 0.00831231207750247 0.0750521825509525 1.40644777411154 0.428571428571429 28.2 28 2 decreased bone volume 0.00831231207750247 0.0750521825509525 1.40644777411154 0.428571428571429 28.2 28 2 small superior cervical ganglion 0.0174953342078329 0.125236385156789 1.40644777411154 0.428571428571429 28.2 28 2 increased bone resorption 0.0174953342078329 0.125236385156789 1.40644777411154 0.428571428571429 28.2 28 2 hypoxia 0.0174953342078329 0.125236385156789 1.40644777411154 0.428571428571429 28.2 28 2 abnormal brainstem morphology 0.0174953342078329 0.125236385156789 1.40644777411154 0.428571428571429 28.2 28 2 abnormal salivary gland morphology 0.0377269377566326 0.21799246845441 1.40644777411154 0.428571428571429 28.2 28 2 trunk curl 0.0377269377566326 0.21799246845441 1.40644777411154 0.428571428571429 28.2 28 2 midline facial cleft 0.0848776336905606 0.353861745054054 1.40644777411154 0.428571428571429 28.2 28 2 megacephaly 0.0848776336905606 0.353861745054054 1.40644777411154 0.428571428571429 28.2 28 2 translucent skin 0.0848776336905606 0.353861745054054 1.40644777411154 0.428571428571429 28.2 28 2 intestinal obstruction 0.0848776336905606 0.353861745054054 1.40644777411154 0.428571428571429 28.2 28 2 split sternum 0.0848776336905606 0.353861745054054 1.40644777411154 0.428571428571429 28.2 28 2 abnormal positive T cell selection 0.0848776336905606 0.353861745054054 1.40644777411154 0.428571428571429 28.2 28 2 increased pulmonary respiratory rate 0.0848776336905606 0.353861745054054 1.40644777411154 0.428571428571429 28.2 28 2 increased stomach tumor incidence 0.0848776336905606 0.353861745054054 1.40644777411154 0.428571428571429 28.2 28 2 decreased compact bone area 0.0848776336905606 0.353861745054054 1.40644777411154 0.428571428571429 28.2 28 2 abnormal renal tubule epithelial cell primary cilium morphology 0.0848776336905606 0.353861745054054 1.40644777411154 0.428571428571429 28.2 28 2 preweaning lethality, incomplete penetrance 1.98527716461099e-18 8.23062824494973e-16 1.40415527570223 0.427872860635697 28.2 28 2 abnormal neurocranium morphology 0.000165220093243545 0.00380541649947517 1.40019689511549 0.426666666666667 28.2 28 2 ventricular septal defect 4.87594062280938e-07 2.75656870437235e-05 1.39955342227766 0.426470588235294 28.2 28 2 diluted coat color 0.00134928968861041 0.0186464338912133 1.39776599772813 0.425925925925926 28.2 28 2 impaired limb coordination 0.00134928968861041 0.0186464338912133 1.39776599772813 0.425925925925926 28.2 28 2 abnormal retinal pigmentation 5.77045310247115e-05 0.00158607757927038 1.39567039653214 0.425287356321839 28.2 28 2 lethality throughout fetal growth and development, incomplete penetrance 1.13896524393187e-08 9.94096857642288e-07 1.39335235722037 0.424581005586592 28.2 28 2 prenatal lethality, complete penetrance 1.25504615181064e-12 2.2299480733064e-10 1.39295666836466 0.424460431654676 28.2 28 2 increased cardiomyocyte apoptosis 0.011777503346464 0.098310535484326 1.39224123093869 0.424242424242424 28.2 28 2 abnormal locomotor coordination 0.011777503346464 0.098310535484326 1.39224123093869 0.424242424242424 28.2 28 2 abnormal leukocyte cell number 0.0249758147391072 0.163924377740182 1.38841639239216 0.423076923076923 28.2 28 2 abnormal kidney cortex morphology 0.0249758147391072 0.163924377740182 1.38841639239216 0.423076923076923 28.2 28 2 decreased Peyer's patch number 0.0249758147391072 0.163924377740182 1.38841639239216 0.423076923076923 28.2 28 2 increased circulating free fatty acid level 0.000319996821666203 0.00614665709571182 1.3866386505325 0.422535211267606 28.2 28 2 trabecula carnea hypoplasia 0.00386004171539323 0.0407722028324445 1.38561151079137 0.422222222222222 28.2 28 2 abnormal myocardial trabeculae morphology 0.00386004171539323 0.0407722028324445 1.38561151079137 0.422222222222222 28.2 28 2 abnormal osteoclast physiology 0.000643215915599633 0.0106666639336939 1.38447202764104 0.421875 28.2 28 2 abnormal neural tube closure 0.000111142422601481 0.00276466776221183 1.38385423557159 0.421686746987952 28.2 28 2 incomplete somite formation 0.007969270130456 0.0723487571149974 1.3817732517587 0.421052631578947 28.2 28 2 stereotypic behavior 0.0545168425916676 0.257439783365305 1.3817732517587 0.421052631578947 28.2 28 2 altered susceptibility to infection 0.0545168425916676 0.257439783365305 1.3817732517587 0.421052631578947 28.2 28 2 decreased tumor incidence 0.0545168425916676 0.257439783365305 1.3817732517587 0.421052631578947 28.2 28 2 increased left ventricle weight 0.0545168425916676 0.257439783365305 1.3817732517587 0.421052631578947 28.2 28 2 decreased fertilization frequency 0.0545168425916676 0.257439783365305 1.3817732517587 0.421052631578947 28.2 28 2 decreased circulating magnesium level 0.0545168425916676 0.257439783365305 1.3817732517587 0.421052631578947 28.2 28 2 decreased susceptibility to weight gain 0.0545168425916676 0.257439783365305 1.3817732517587 0.421052631578947 28.2 28 2 decreased spleen weight 0.000444876764086197 0.00804822509574121 1.3792700393461 0.420289855072464 28.2 28 2 preweaning lethality, complete penetrance 4.74157519079392e-30 7.86311219139992e-27 1.37920576767604 0.42027027027027 28.2 28 2 abnormal immune system physiology 3.38601222894226e-06 0.000141558074277208 1.37620158542097 0.419354838709677 28.2 28 2 abnormal object recognition memory 0.0166854874489092 0.120652111937916 1.37620158542097 0.419354838709677 28.2 28 2 increased lung adenoma incidence 0.0166854874489092 0.120652111937916 1.37620158542097 0.419354838709677 28.2 28 2 pale kidney 0.0166854874489092 0.120652111937916 1.37620158542097 0.419354838709677 28.2 28 2 abnormal CD8-positive, alpha beta T cell morphology 0.0166854874489092 0.120652111937916 1.37620158542097 0.419354838709677 28.2 28 2 small seminiferous tubules 0.000308015666612774 0.00600293685940519 1.37477102244236 0.418918918918919 28.2 28 2 decreased oxygen consumption 0.00541513655857926 0.0539885859297231 1.3737396863415 0.418604651162791 28.2 28 2 abnormal embryo turning 0.00181218984051202 0.0236631088098354 1.37235207049671 0.418181818181818 28.2 28 2 abnormal eye morphology 1.1587922595862e-06 5.9728551059622e-05 1.36934723330764 0.41726618705036 28.2 28 2 abnormal axon morphology 1.8196809901768e-05 0.000595586376719051 1.36737978038622 0.416666666666667 28.2 28 2 vertebral transformation 0.00369245761862702 0.0395053261347729 1.36737978038622 0.416666666666667 28.2 28 2 abnormal osteoclast morphology 0.00369245761862702 0.0395053261347729 1.36737978038622 0.416666666666667 28.2 28 2 decreased metastatic potential 0.0356720805624331 0.211272143807268 1.36737978038622 0.416666666666667 28.2 28 2 abnormal impulse conducting system conduction 0.0356720805624331 0.211272143807268 1.36737978038622 0.416666666666667 28.2 28 2 abnormal tumor morphology 0.0356720805624331 0.211272143807268 1.36737978038622 0.416666666666667 28.2 28 2 increased circulating total protein level 0.0356720805624331 0.211272143807268 1.36737978038622 0.416666666666667 28.2 28 2 abnormal superior cervical ganglion morphology 0.125547965811639 0.464387457184315 1.36737978038622 0.416666666666667 28.2 28 2 abnormal enteric nervous system morphology 0.125547965811639 0.464387457184315 1.36737978038622 0.416666666666667 28.2 28 2 abnormal mating frequency 0.125547965811639 0.464387457184315 1.36737978038622 0.416666666666667 28.2 28 2 abnormal pilomotor reflex 0.125547965811639 0.464387457184315 1.36737978038622 0.416666666666667 28.2 28 2 dilated bile duct 0.125547965811639 0.464387457184315 1.36737978038622 0.416666666666667 28.2 28 2 small intestinal inflammation 0.125547965811639 0.464387457184315 1.36737978038622 0.416666666666667 28.2 28 2 decreased circulating ketone body level 0.125547965811639 0.464387457184315 1.36737978038622 0.416666666666667 28.2 28 2 stria vascularis degeneration 0.125547965811639 0.464387457184315 1.36737978038622 0.416666666666667 28.2 28 2 abnormal cochlear outer hair cell physiology 0.125547965811639 0.464387457184315 1.36737978038622 0.416666666666667 28.2 28 2 hematuria 0.125547965811639 0.464387457184315 1.36737978038622 0.416666666666667 28.2 28 2 decreased renal glomerular filtration rate 0.125547965811639 0.464387457184315 1.36737978038622 0.416666666666667 28.2 28 2 decreased keratinocyte proliferation 0.125547965811639 0.464387457184315 1.36737978038622 0.416666666666667 28.2 28 2 increased skeletal muscle glycogen level 0.125547965811639 0.464387457184315 1.36737978038622 0.416666666666667 28.2 28 2 abnormal neuromuscular synapse morphology 0.000427072859172503 0.00784017518222583 1.36737978038622 0.416666666666667 28.2 28 2 abnormal limb bone morphology 0.011224120680731 0.0944839262041231 1.36737978038622 0.416666666666667 28.2 28 2 abnormal trophoblast giant cell morphology 0.011224120680731 0.0944839262041231 1.36737978038622 0.416666666666667 28.2 28 2 abnormal brain morphology 2.02401540901087e-07 1.29095854613194e-05 1.36568117196338 0.416149068322981 28.2 28 2 decreased leukocyte cell number 1.59373238634548e-06 7.48001756798942e-05 1.36538360552434 0.416058394160584 28.2 28 2 abnormal embryo size 1.26874129781628e-05 0.000442159201445232 1.36495963918199 0.415929203539823 28.2 28 2 abnormal mesoderm development 0.00252520670951501 0.0310962954946464 1.36221985668665 0.415094339622642 28.2 28 2 abnormal placenta development 0.00252520670951501 0.0310962954946464 1.36221985668665 0.415094339622642 28.2 28 2 enlarged kidney 0.00252520670951501 0.0310962954946464 1.36221985668665 0.415094339622642 28.2 28 2 abnormal embryonic tissue morphology 7.79323091836624e-07 4.16895955041635e-05 1.36179863842546 0.414965986394558 28.2 28 2 Leydig cell hyperplasia 0.00759126723889919 0.0703287793547923 1.36070963511604 0.414634146341463 28.2 28 2 increased susceptibility to induced arthritis 0.0236333248556986 0.158031977361694 1.35794957500424 0.413793103448276 28.2 28 2 enlarged epididymis 0.0236333248556986 0.158031977361694 1.35794957500424 0.413793103448276 28.2 28 2 decreased bone strength 0.0236333248556986 0.158031977361694 1.35794957500424 0.413793103448276 28.2 28 2 delayed bone ossification 0.000408621638759272 0.00752923204750881 1.35644074214313 0.413333333333333 28.2 28 2 embryonic lethality during organogenesis, incomplete penetrance 1.05928065675816e-09 1.19770937894814e-07 1.35548952142634 0.41304347826087 28.2 28 2 abnormal spermatogenesis 4.67476891922367e-08 3.52378414744511e-06 1.35548952142634 0.41304347826087 28.2 28 2 decreased birth body size 1.67292488525779e-05 0.000554853420277168 1.35298630901373 0.412280701754386 28.2 28 2 abnormal oocyte morphology 0.0157983367396453 0.116612352047085 1.3512929594405 0.411764705882353 28.2 28 2 thin skin 0.0157983367396453 0.116612352047085 1.3512929594405 0.411764705882353 28.2 28 2 abnormal brown adipose tissue morphology 0.0157983367396453 0.116612352047085 1.3512929594405 0.411764705882353 28.2 28 2 decreased cytotoxic T cell cytolysis 0.0157983367396453 0.116612352047085 1.3512929594405 0.411764705882353 28.2 28 2 abnormal bone marrow cavity morphology 0.0789351292827309 0.339121129690489 1.3512929594405 0.411764705882353 28.2 28 2 abnormal dorsal-ventral axis patterning 0.0789351292827309 0.339121129690489 1.3512929594405 0.411764705882353 28.2 28 2 abnormal embryonic-extraembryonic boundary morphology 0.0789351292827309 0.339121129690489 1.3512929594405 0.411764705882353 28.2 28 2 increased circulating magnesium level 0.0789351292827309 0.339121129690489 1.3512929594405 0.411764705882353 28.2 28 2 increased trabecular bone mass 0.0789351292827309 0.339121129690489 1.3512929594405 0.411764705882353 28.2 28 2 delayed heart development 0.0789351292827309 0.339121129690489 1.3512929594405 0.411764705882353 28.2 28 2 impaired balance 4.74910038354729e-05 0.00133300753161164 1.3512929594405 0.411764705882353 28.2 28 2 perinatal lethality, incomplete penetrance 1.98163575356897e-09 1.89589189884723e-07 1.35043879195665 0.411504424778761 28.2 28 2 decreased percent body fat/body weight 0.000564559328144884 0.00958594763658975 1.34864855051791 0.410958904109589 28.2 28 2 abnormal coat/hair pigmentation 2.29740213004093e-05 0.000714348474809602 1.34784578352356 0.410714285714286 28.2 28 2 increased inflammatory response 9.40314441246416e-05 0.00236265876020248 1.34722892046474 0.410526315789474 28.2 28 2 abnormal cytokine secretion 9.37804615471507e-07 4.96338081060718e-05 1.34251832983374 0.409090909090909 28.2 28 2 osteoporosis 0.00719422153807235 0.0668995367325419 1.34251832983374 0.409090909090909 28.2 28 2 abnormal tail movements 0.0509687144117528 0.257439783365305 1.34251832983374 0.409090909090909 28.2 28 2 intestinal inflammation 0.0509687144117528 0.257439783365305 1.34251832983374 0.409090909090909 28.2 28 2 increased coping response 0.0509687144117528 0.257439783365305 1.34251832983374 0.409090909090909 28.2 28 2 aphakia 0.0509687144117528 0.257439783365305 1.34251832983374 0.409090909090909 28.2 28 2 abnormal occipital bone morphology 0.0509687144117528 0.257439783365305 1.34251832983374 0.409090909090909 28.2 28 2 failure of palatal shelf elevation 0.0509687144117528 0.257439783365305 1.34251832983374 0.409090909090909 28.2 28 2 pulmonary vascular congestion 0.0509687144117528 0.257439783365305 1.34251832983374 0.409090909090909 28.2 28 2 increased mammary gland tumor incidence 0.0509687144117528 0.257439783365305 1.34251832983374 0.409090909090909 28.2 28 2 increased bone volume 0.0509687144117528 0.257439783365305 1.34251832983374 0.409090909090909 28.2 28 2 impaired humoral immune response 0.0509687144117528 0.257439783365305 1.34251832983374 0.409090909090909 28.2 28 2 hemorrhage 1.73435967528314e-09 1.81020340749765e-07 1.34061404851483 0.408510638297872 28.2 28 2 prenatal lethality, incomplete penetrance 9.12559841383985e-12 1.41874537840166e-09 1.33859283764124 0.407894736842105 28.2 28 2 abnormal axial skeleton morphology 0.000537203931638763 0.00918415656324002 1.33859283764124 0.407894736842105 28.2 28 2 increased cell proliferation 0.00333364966138694 0.0366837712087301 1.3369935630443 0.407407407407407 28.2 28 2 abnormal trigeminal ganglion morphology 0.0334607151256112 0.200562720180621 1.3369935630443 0.407407407407407 28.2 28 2 increased circulating alkaline phosphatase level 6.25077949346618e-07 3.45529199777714e-05 1.3369935630443 0.407407407407407 28.2 28 2 abnormal lumbar vertebrae morphology 0.022218453775787 0.149778871998022 1.33319528587656 0.40625 28.2 28 2 abnormal T cell activation 0.00073947546100769 0.0116636212288308 1.33042357010551 0.405405405405405 28.2 28 2 increased white adipose tissue amount 0.0148770044454689 0.110964163592515 1.33042357010551 0.405405405405405 28.2 28 2 increased circulating phosphate level 0.0148770044454689 0.110964163592515 1.33042357010551 0.405405405405405 28.2 28 2 anophthalmia 0.00024343772788824 0.0049321815491703 1.32743385421763 0.404494382022472 28.2 28 2 neuron degeneration 0.00678981530611053 0.0644643724196562 1.3266493188428 0.404255319148936 28.2 28 2 abnormal T-helper 1 physiology 0.00678981530611053 0.0644643724196562 1.3266493188428 0.404255319148936 28.2 28 2 premature death 1.31358540695413e-29 1.6337718498992e-26 1.32640603086942 0.40418118466899 28.2 28 2 abnormal leukocyte migration 0.0046174610686486 0.0467858835367145 1.32530655637433 0.403846153846154 28.2 28 2 increased bone mineral content 5.6201921482563e-05 0.00156203664455727 1.32472756705307 0.403669724770642 28.2 28 2 impaired glucose tolerance 1.85460563010795e-09 1.84533260195741e-07 1.32327075521247 0.403225806451613 28.2 28 2 increased total body fat amount 9.14424094744274e-06 0.000336982212692797 1.3224807428213 0.402985074626866 28.2 28 2 decreased white adipose tissue amount 0.00147900397629937 0.0199946869078515 1.3224807428213 0.402985074626866 28.2 28 2 abnormal lipid homeostasis 1.69536630554713e-05 0.000558572673516355 1.31268458917077 0.4 28.2 28 2 embryonic lethality before implantation, complete penetrance 2.43699290081866e-05 0.000743806115433917 1.31268458917077 0.4 28.2 28 2 abnormal retinal pigment epithelium morphology 0.000661438410741655 0.0109324122705639 1.31268458917077 0.4 28.2 28 2 abnormal platelet physiology 0.00434795620863683 0.0443259879876398 1.31268458917077 0.4 28.2 28 2 abnormal skin pigmentation 0.013950777287831 0.105242283876668 1.31268458917077 0.4 28.2 28 2 ovary cysts 0.0207890198477405 0.140332935878574 1.31268458917077 0.4 28.2 28 2 increased circulating serum albumin level 0.0207890198477405 0.140332935878574 1.31268458917077 0.4 28.2 28 2 decreased triglyceride level 0.0207890198477405 0.140332935878574 1.31268458917077 0.4 28.2 28 2 decreased circulating thyroxine level 0.0207890198477405 0.140332935878574 1.31268458917077 0.4 28.2 28 2 abnormal pericardium morphology 0.0728390961129844 0.317315677024604 1.31268458917077 0.4 28.2 28 2 abnormal cell proliferation 0.0728390961129844 0.317315677024604 1.31268458917077 0.4 28.2 28 2 increased mammary adenocarcinoma incidence 0.0728390961129844 0.317315677024604 1.31268458917077 0.4 28.2 28 2 abnormal lens epithelium morphology 0.0728390961129844 0.317315677024604 1.31268458917077 0.4 28.2 28 2 enhanced behavioral response to xenobiotic 0.0728390961129844 0.317315677024604 1.31268458917077 0.4 28.2 28 2 increased skin tumor incidence 0.0728390961129844 0.317315677024604 1.31268458917077 0.4 28.2 28 2 increased circulating HDL cholesterol level 0.000104722383175106 0.00261805957937765 1.31268458917077 0.4 28.2 28 2 enlarged liver 0.000151074581665148 0.00353816299516519 1.31268458917077 0.4 28.2 28 2 decreased circulating alkaline phosphatase level 0.00638654386237337 0.0613379453963466 1.31268458917077 0.4 28.2 28 2 abnormal thyroid gland morphology 0.0473437703565786 0.248980187657483 1.31268458917077 0.4 28.2 28 2 abnormal nest building behavior 0.0473437703565786 0.248980187657483 1.31268458917077 0.4 28.2 28 2 abnormal keratinocyte physiology 0.0473437703565786 0.248980187657483 1.31268458917077 0.4 28.2 28 2 increased liver glycogen level 0.0473437703565786 0.248980187657483 1.31268458917077 0.4 28.2 28 2 muscular ventricular septal defect 0.00296955408302093 0.0337181294398785 1.31268458917077 0.4 28.2 28 2 increased metastatic potential 0.0312142478381608 0.188688800722783 1.31268458917077 0.4 28.2 28 2 arrested T cell differentiation 0.0312142478381608 0.188688800722783 1.31268458917077 0.4 28.2 28 2 abnormal lactation 0.0312142478381608 0.188688800722783 1.31268458917077 0.4 28.2 28 2 absent egg cylinders 0.114527809474842 0.432303377949423 1.31268458917077 0.4 28.2 28 2 arthritis 0.114527809474842 0.432303377949423 1.31268458917077 0.4 28.2 28 2 abnormal energy homeostasis 0.114527809474842 0.432303377949423 1.31268458917077 0.4 28.2 28 2 abnormal coronary vessel morphology 0.114527809474842 0.432303377949423 1.31268458917077 0.4 28.2 28 2 increased insulin sensitivity 7.77700400739796e-06 0.000297061974427301 1.30809478291493 0.398601398601399 28.2 28 2 hypoglycemia 0.000297655424450942 0.0058763322882676 1.30562714514297 0.397849462365591 28.2 28 2 postnatal lethality 1.73834633822176e-06 8.00766021541969e-05 1.30477685068179 0.397590361445783 28.2 28 2 lung inflammation 1.51555548003863e-05 0.000519992311254635 1.30303249660334 0.397058823529412 28.2 28 2 abnormal bone mineralization 4.50324688706125e-05 0.00128756627949021 1.30183595620242 0.396694214876033 28.2 28 2 abnormal embryonic neuroepithelium morphology 0.0040836039197342 0.0424132139888886 1.3013683427124 0.396551724137931 28.2 28 2 azoospermia 3.37499937119696e-06 0.000141558074277208 1.3003007722918 0.39622641509434 28.2 28 2 increased circulating bilirubin level 0.00599050299183002 0.0585515763936235 1.3003007722918 0.39622641509434 28.2 28 2 ataxia 1.80228778053976e-07 1.16446515690718e-05 1.29968771205027 0.396039603960396 28.2 28 2 increased oxygen consumption 0.00058716155862673 0.00980244548378518 1.29742081487809 0.395348837209302 28.2 28 2 abnormal organ of Corti morphology 0.0130393685583521 0.100109349657102 1.29742081487809 0.395348837209302 28.2 28 2 decreased body weight 3.09367364458998e-38 1.53910263818352e-34 1.29624952363592 0.394991922455574 28.2 28 2 abnormal compact bone morphology 0.0193820485639556 0.135429342142808 1.29541242352378 0.394736842105263 28.2 28 2 abnormal ovary morphology 0.00179744441069179 0.0235323314294517 1.29419607383034 0.394366197183099 28.2 28 2 abnormal kidney morphology 1.46365724642355e-06 6.94726406484733e-05 1.29393195218261 0.394285714285714 28.2 28 2 abnormal motor coordination/ balance 0.000263998572409719 0.00525357159095341 1.29279542872879 0.393939393939394 28.2 28 2 abnormal skeleton physiology 0.0290050715548468 0.180517119221167 1.29279542872879 0.393939393939394 28.2 28 2 myeloid hyperplasia 0.0290050715548468 0.180517119221167 1.29279542872879 0.393939393939394 28.2 28 2 increased osteoclast cell number 0.00382691814314758 0.0407685605185422 1.29116516967617 0.39344262295082 28.2 28 2 increased leukocyte cell number 1.27092996596318e-05 0.000442159201445232 1.29005209625403 0.393103448275862 28.2 28 2 increased neutrophil cell number 1.27092996596318e-05 0.000442159201445232 1.29005209625403 0.393103448275862 28.2 28 2 enhanced long term potentiation 0.00560598079735865 0.0557795089337185 1.28924379293558 0.392857142857143 28.2 28 2 rib bifurcation 0.0437912557194675 0.232261724098455 1.28924379293558 0.392857142857143 28.2 28 2 increased triglyceride level 0.0437912557194675 0.232261724098455 1.28924379293558 0.392857142857143 28.2 28 2 corneal vascularization 0.0437912557194675 0.232261724098455 1.28924379293558 0.392857142857143 28.2 28 2 abnormal mitotic spindle morphology 0.0437912557194675 0.232261724098455 1.28924379293558 0.392857142857143 28.2 28 2 decreased grip strength 9.98800994618096e-08 6.99864077214792e-06 1.28870861493934 0.392694063926941 28.2 28 2 abnormal response to infection 0.00115979953846366 0.0166282498670222 1.28776019823715 0.392405063291139 28.2 28 2 abnormal sternum morphology 0.00245350041095251 0.0307460064092916 1.28414796766706 0.391304347826087 28.2 28 2 atrial septal defect 0.0121558091995491 0.0986813127423095 1.28414796766706 0.391304347826087 28.2 28 2 abnormal blood vessel physiology 0.0669197337736357 0.296460975533248 1.28414796766706 0.391304347826087 28.2 28 2 abnormal pulmonary artery morphology 0.0669197337736357 0.296460975533248 1.28414796766706 0.391304347826087 28.2 28 2 abnormal cranial nerve morphology 0.0669197337736357 0.296460975533248 1.28414796766706 0.391304347826087 28.2 28 2 abnormal circulating insulin level 0.0669197337736357 0.296460975533248 1.28414796766706 0.391304347826087 28.2 28 2 abnormal cochlear ganglion morphology 0.0669197337736357 0.296460975533248 1.28414796766706 0.391304347826087 28.2 28 2 abnormal lens development 0.0669197337736357 0.296460975533248 1.28414796766706 0.391304347826087 28.2 28 2 decreased effector memory CD8-positive, alpha-beta T cell number 0.0669197337736357 0.296460975533248 1.28414796766706 0.391304347826087 28.2 28 2 decreased circulating LDL cholesterol level 0.00357965126912714 0.0386233616091275 1.28191854411208 0.390625 28.2 28 2 abnormal mammary gland development 0.0180208637191474 0.12826008154901 1.28066789187392 0.390243902439024 28.2 28 2 hemopericardium 0.0180208637191474 0.12826008154901 1.28066789187392 0.390243902439024 28.2 28 2 short snout 0.000218462604122281 0.00456660275423676 1.27622112836047 0.388888888888889 28.2 28 2 abnormal neural tube morphology 6.92875867175508e-06 0.000273575987237948 1.27622112836047 0.388888888888889 28.2 28 2 abnormal mitral valve morphology 0.104080631238798 0.398002413845518 1.27622112836047 0.388888888888889 28.2 28 2 abnormal stomach glandular epithelium morphology 0.104080631238798 0.398002413845518 1.27622112836047 0.388888888888889 28.2 28 2 delayed kidney development 0.104080631238798 0.398002413845518 1.27622112836047 0.388888888888889 28.2 28 2 abnormal radius morphology 0.104080631238798 0.398002413845518 1.27622112836047 0.388888888888889 28.2 28 2 abnormal iron level 0.104080631238798 0.398002413845518 1.27622112836047 0.388888888888889 28.2 28 2 absent inner cell mass 0.104080631238798 0.398002413845518 1.27622112836047 0.388888888888889 28.2 28 2 abnormal neutrophil morphology 0.104080631238798 0.398002413845518 1.27622112836047 0.388888888888889 28.2 28 2 abnormal eye anterior chamber morphology 0.104080631238798 0.398002413845518 1.27622112836047 0.388888888888889 28.2 28 2 abnormal pregnancy 0.104080631238798 0.398002413845518 1.27622112836047 0.388888888888889 28.2 28 2 decreased tumor latency 0.104080631238798 0.398002413845518 1.27622112836047 0.388888888888889 28.2 28 2 primary atelectasis 0.104080631238798 0.398002413845518 1.27622112836047 0.388888888888889 28.2 28 2 decreased fluid intake 0.104080631238798 0.398002413845518 1.27622112836047 0.388888888888889 28.2 28 2 abnormal behavior 5.0625130048023e-09 4.57927312707117e-07 1.27490949307952 0.388489208633094 28.2 28 2 decreased susceptibility to bacterial infection induced morbidity/mortality 0.0403903070313723 0.225765940962159 1.27033992500397 0.387096774193548 28.2 28 2 abnormal lung morphology 0.000133122255913525 0.00315372963414185 1.26856073743394 0.38655462184874 28.2 28 2 increased T cell number 0.000950889699495108 0.0139137536911417 1.26793397817631 0.386363636363636 28.2 28 2 abnormal astrocyte morphology 0.0167196463118617 0.120652111937916 1.26793397817631 0.386363636363636 28.2 28 2 renal interstitial fibrosis 0.0167196463118617 0.120652111937916 1.26793397817631 0.386363636363636 28.2 28 2 lethality, incomplete penetrance 0.0167196463118617 0.120652111937916 1.26793397817631 0.386363636363636 28.2 28 2 embryonic lethality, incomplete penetrance 0.0167196463118617 0.120652111937916 1.26793397817631 0.386363636363636 28.2 28 2 abnormal heart development 1.25157440785541e-05 0.000442159201445232 1.26698987245913 0.386075949367089 28.2 28 2 absent vitelline blood vessels 0.00714924875509286 0.0667307927890937 1.26662548077881 0.385964912280702 28.2 28 2 limb grasping 3.51081622600609e-06 0.000145552589369836 1.26219672035651 0.384615384615385 28.2 28 2 decreased neutrophil cell number 0.000179182614735365 0.00393531288995927 1.26219672035651 0.384615384615385 28.2 28 2 abnormal circulating hormone level 0.0248504049306234 0.163788937930364 1.26219672035651 0.384615384615385 28.2 28 2 abnormal xiphoid process morphology 0.0613237426174981 0.275348032059615 1.26219672035651 0.384615384615385 28.2 28 2 abnormal Mullerian duct morphology 0.0613237426174981 0.275348032059615 1.26219672035651 0.384615384615385 28.2 28 2 decreased bone resorption 0.0613237426174981 0.275348032059615 1.26219672035651 0.384615384615385 28.2 28 2 absent common myeloid progenitor cells 0.166508431038419 0.52033884699506 1.26219672035651 0.384615384615385 28.2 28 2 abnormal mast cell morphology 0.166508431038419 0.52033884699506 1.26219672035651 0.384615384615385 28.2 28 2 abnormal renal/urinary system morphology 0.166508431038419 0.52033884699506 1.26219672035651 0.384615384615385 28.2 28 2 abnormal digestion 0.166508431038419 0.52033884699506 1.26219672035651 0.384615384615385 28.2 28 2 abnormal tail bud morphology 0.166508431038419 0.52033884699506 1.26219672035651 0.384615384615385 28.2 28 2 abnormal bile duct development 0.166508431038419 0.52033884699506 1.26219672035651 0.384615384615385 28.2 28 2 axonal dystrophy 0.166508431038419 0.52033884699506 1.26219672035651 0.384615384615385 28.2 28 2 abnormal afterhyperpolarization 0.166508431038419 0.52033884699506 1.26219672035651 0.384615384615385 28.2 28 2 small otic vesicle 0.166508431038419 0.52033884699506 1.26219672035651 0.384615384615385 28.2 28 2 abnormal vertebral arch development 0.166508431038419 0.52033884699506 1.26219672035651 0.384615384615385 28.2 28 2 empty decidua capsularis 0.166508431038419 0.52033884699506 1.26219672035651 0.384615384615385 28.2 28 2 abnormal aorta tunica media morphology 0.166508431038419 0.52033884699506 1.26219672035651 0.384615384615385 28.2 28 2 reduced female fertility 2.08802852091442e-07 1.31492935336067e-05 1.25893241849352 0.383620689655172 28.2 28 2 abnormal seminiferous tubule morphology 3.44740332539938e-05 0.00101484210318709 1.25873864715005 0.383561643835616 28.2 28 2 seminiferous tubule degeneration 0.00290388310494396 0.0337181294398785 1.25873864715005 0.383561643835616 28.2 28 2 decreased body size 6.86700005410803e-22 3.79592502990971e-19 1.25840063999453 0.383458646616541 28.2 28 2 decreased heart weight 0.00186191812237612 0.0241854899708125 1.25596365013253 0.382716049382716 28.2 28 2 abnormal testis morphology 0.000240819990798927 0.00493036812438133 1.25561134616334 0.382608695652174 28.2 28 2 abnormal embryo development 7.08739232446005e-05 0.00185577772706257 1.25477203376618 0.382352941176471 28.2 28 2 decreased circulating alanine transaminase level 0.004227714397915 0.0435392679010077 1.25477203376618 0.382352941176471 28.2 28 2 short maxilla 0.0371806692975906 0.215429980324531 1.25477203376618 0.382352941176471 28.2 28 2 lung hemorrhage 0.0371806692975906 0.215429980324531 1.25477203376618 0.382352941176471 28.2 28 2 abnormal bone remodeling 0.0371806692975906 0.215429980324531 1.25477203376618 0.382352941176471 28.2 28 2 abnormal direction of heart looping 0.0371806692975906 0.215429980324531 1.25477203376618 0.382352941176471 28.2 28 2 impaired coordination 4.36060549986279e-10 5.04511915391102e-08 1.25198241163686 0.38150289017341 28.2 28 2 increased food intake 0.00173316611457653 0.0228133721968655 1.25017579921026 0.380952380952381 28.2 28 2 abnormal pancreas morphology 0.0229413107446978 0.15402566930482 1.25017579921026 0.380952380952381 28.2 28 2 liver degeneration 0.0944465781784318 0.367949668314564 1.25017579921026 0.380952380952381 28.2 28 2 decreased cochlear outer hair cell number 0.0944465781784318 0.367949668314564 1.25017579921026 0.380952380952381 28.2 28 2 complete atrioventricular septal defect 0.0944465781784318 0.367949668314564 1.25017579921026 0.380952380952381 28.2 28 2 corneal opacity 0.00392767756693049 0.0413987201175407 1.24797478547925 0.380281690140845 28.2 28 2 decreased total body fat amount 1.1760348667922e-09 1.29605726180202e-07 1.24783639838838 0.380239520958084 28.2 28 2 cataract 0.000209586652600335 0.0044369940284539 1.24759279136065 0.380165289256198 28.2 28 2 abnormal myocardium layer morphology 0.00251175439228733 0.0310962954946464 1.24621954668111 0.379746835443038 28.2 28 2 decreased bone mineral density 6.02283334791723e-08 4.47217849341615e-06 1.24606337881812 0.379699248120301 28.2 28 2 dermatitis 0.00902269837670099 0.0795885184824245 1.24478711042056 0.379310344827586 28.2 28 2 cochlear ganglion degeneration 0.00902269837670099 0.0795885184824245 1.24478711042056 0.379310344827586 28.2 28 2 abnormal spinal nerve morphology 0.0561099912473264 0.260533143884761 1.24478711042056 0.379310344827586 28.2 28 2 aphagia 0.0561099912473264 0.260533143884761 1.24478711042056 0.379310344827586 28.2 28 2 abnormal blood vessel morphology 5.76320565261112e-05 0.00158607757927038 1.24478711042056 0.379310344827586 28.2 28 2 impaired swimming 0.00572048815348248 0.0568052466338829 1.24307252762383 0.378787878787879 28.2 28 2 abnormal craniofacial morphology 0.000669499377462388 0.0109647010883142 1.24258978101116 0.378640776699029 28.2 28 2 malocclusion 0.0341793726390658 0.203643567520183 1.24172866543181 0.378378378378378 28.2 28 2 abnormal breathing pattern 0.0341793726390658 0.203643567520183 1.24172866543181 0.378378378378378 28.2 28 2 decreased width of hypertrophic chondrocyte zone 0.0341793726390658 0.203643567520183 1.24172866543181 0.378378378378378 28.2 28 2 skin inflammation 0.0341793726390658 0.203643567520183 1.24172866543181 0.378378378378378 28.2 28 2 thin ventricular wall 0.00149812550995492 0.0201983046396361 1.23975766755017 0.377777777777778 28.2 28 2 seizures 0.000402834125687921 0.00747798423618435 1.23783853803384 0.37719298245614 28.2 28 2 respiratory distress 1.84819274674273e-05 0.000600964634970268 1.23301298115751 0.375722543352601 28.2 28 2 short mandible 0.0122204327326336 0.0986813127423095 1.2306418023476 0.375 28.2 28 2 abnormal eye development 0.0122204327326336 0.0986813127423095 1.2306418023476 0.375 28.2 28 2 decreased bone mineral content 3.14142846389328e-06 0.000133577834255291 1.2306418023476 0.375 28.2 28 2 increased circulating insulin level 4.04339886084907e-05 0.00116952961236768 1.2306418023476 0.375 28.2 28 2 abnormal posture 0.00313375348875239 0.0352724515985138 1.2306418023476 0.375 28.2 28 2 abnormal tooth morphology 0.00772169509032411 0.0709811150942452 1.2306418023476 0.375 28.2 28 2 abnormal pancreatic beta cell morphology 0.0313901815162989 0.189292306719499 1.2306418023476 0.375 28.2 28 2 failure of primitive streak formation 0.0512934189847237 0.257439783365305 1.2306418023476 0.375 28.2 28 2 abnormal depression-related behavior 0.0512934189847237 0.257439783365305 1.2306418023476 0.375 28.2 28 2 abnormal spongiotrophoblast layer morphology 0.0512934189847237 0.257439783365305 1.2306418023476 0.375 28.2 28 2 increased fatty acid level 0.0512934189847237 0.257439783365305 1.2306418023476 0.375 28.2 28 2 abnormal nursing 0.0856683257003573 0.353861745054054 1.2306418023476 0.375 28.2 28 2 blindness 0.0856683257003573 0.353861745054054 1.2306418023476 0.375 28.2 28 2 abnormal cardiac muscle contractility 0.0856683257003573 0.353861745054054 1.2306418023476 0.375 28.2 28 2 increased body temperature 0.0856683257003573 0.353861745054054 1.2306418023476 0.375 28.2 28 2 abnormal inner cell mass apoptosis 0.0856683257003573 0.353861745054054 1.2306418023476 0.375 28.2 28 2 abnormal truncus arteriosus septation 0.0856683257003573 0.353861745054054 1.2306418023476 0.375 28.2 28 2 vasculature congestion 0.148619084755079 0.473354639344763 1.2306418023476 0.375 28.2 28 2 abnormal hair follicle orientation 0.148619084755079 0.473354639344763 1.2306418023476 0.375 28.2 28 2 poor circulation 0.148619084755079 0.473354639344763 1.2306418023476 0.375 28.2 28 2 abnormal meiosis 0.148619084755079 0.473354639344763 1.2306418023476 0.375 28.2 28 2 abnormal olfaction 0.148619084755079 0.473354639344763 1.2306418023476 0.375 28.2 28 2 increased intestinal adenocarcinoma incidence 0.148619084755079 0.473354639344763 1.2306418023476 0.375 28.2 28 2 abnormal pulmonary elastic fiber morphology 0.148619084755079 0.473354639344763 1.2306418023476 0.375 28.2 28 2 large intestinal inflammation 0.148619084755079 0.473354639344763 1.2306418023476 0.375 28.2 28 2 bowed tibia 0.148619084755079 0.473354639344763 1.2306418023476 0.375 28.2 28 2 increased cochlear outer hair cell number 0.148619084755079 0.473354639344763 1.2306418023476 0.375 28.2 28 2 dystonia 0.148619084755079 0.473354639344763 1.2306418023476 0.375 28.2 28 2 abnormal Langerhans cell physiology 0.148619084755079 0.473354639344763 1.2306418023476 0.375 28.2 28 2 decreased creatinine clearance 0.148619084755079 0.473354639344763 1.2306418023476 0.375 28.2 28 2 impaired somite development 0.148619084755079 0.473354639344763 1.2306418023476 0.375 28.2 28 2 dilated respiratory conducting tubes 0.148619084755079 0.473354639344763 1.2306418023476 0.375 28.2 28 2 abnormal pulmonary alveolus wall morphology 0.148619084755079 0.473354639344763 1.2306418023476 0.375 28.2 28 2 abnormal CNS synaptic transmission 0.00119810891207391 0.017128137464275 1.22649822725552 0.373737373737374 28.2 28 2 rib fusion 0.00713567789445855 0.0667293186558859 1.22451920631602 0.373134328358209 28.2 28 2 abnormal bone structure 9.05845227402249e-06 0.000336982212692797 1.22426541995201 0.373056994818653 28.2 28 2 postnatal growth retardation 4.98672425740096e-15 1.30573437792473e-12 1.22259839187474 0.372549019607843 28.2 28 2 abnormal dendritic spine morphology 0.0179387571649394 0.128042061543147 1.22259839187474 0.372549019607843 28.2 28 2 increased blood urea nitrogen level 0.000117714837540475 0.00287074174884247 1.22215461750382 0.372413793103448 28.2 28 2 abnormal heart morphology 1.43684614753977e-06 6.94010639224308e-05 1.22176271286457 0.372294372294372 28.2 28 2 abnormal homeostasis 0.0288091283366063 0.180517119221167 1.22110194341467 0.372093023255814 28.2 28 2 domed cranium 0.00659039397552424 0.0631738150833008 1.21892140423 0.371428571428571 28.2 28 2 decreased bone mineralization 0.046866643972502 0.24793929266506 1.21892140423 0.371428571428571 28.2 28 2 decreased rib number 0.00248657309861707 0.0310821637327134 1.21681436636616 0.370786516853933 28.2 28 2 abnormal maxilla morphology 0.0165045939174607 0.120652111937916 1.21544869367664 0.37037037037037 28.2 28 2 abnormal small intestine morphology 0.0165045939174607 0.120652111937916 1.21544869367664 0.37037037037037 28.2 28 2 abnormal heart valve morphology 0.0777137587891965 0.336489077437992 1.21544869367664 0.37037037037037 28.2 28 2 abnormal skin appearance 0.0777137587891965 0.336489077437992 1.21544869367664 0.37037037037037 28.2 28 2 abnormal locomotor behavior 0.00229995789247373 0.0288946730178202 1.21280641390778 0.369565217391304 28.2 28 2 abnormal myelin sheath morphology 0.0264278354222976 0.171419141102908 1.21280641390778 0.369565217391304 28.2 28 2 hydronephrosis 0.00358673227405365 0.0386233616091275 1.21110780548494 0.369047619047619 28.2 28 2 arrest of spermatogenesis 0.00358673227405365 0.0386233616091275 1.21110780548494 0.369047619047619 28.2 28 2 abnormal cell morphology 0.00081793410194174 0.0127962960916986 1.20905159528887 0.368421052631579 28.2 28 2 decreased total retina thickness 0.0428111450162135 0.229510179370326 1.20905159528887 0.368421052631579 28.2 28 2 small superior vagus ganglion 0.132992841282957 0.464395062260441 1.20905159528887 0.368421052631579 28.2 28 2 increased malignant tumor incidence 0.132992841282957 0.464395062260441 1.20905159528887 0.368421052631579 28.2 28 2 abnormal ear morphology 0.132992841282957 0.464395062260441 1.20905159528887 0.368421052631579 28.2 28 2 abnormal digestive system development 0.132992841282957 0.464395062260441 1.20905159528887 0.368421052631579 28.2 28 2 oliguria 0.132992841282957 0.464395062260441 1.20905159528887 0.368421052631579 28.2 28 2 abnormal photoreceptor inner segment morphology 0.132992841282957 0.464395062260441 1.20905159528887 0.368421052631579 28.2 28 2 increased circulating VLDL cholesterol level 0.132992841282957 0.464395062260441 1.20905159528887 0.368421052631579 28.2 28 2 Leydig cell hypoplasia 0.132992841282957 0.464395062260441 1.20905159528887 0.368421052631579 28.2 28 2 short limbs 0.00331280935945776 0.0366837712087301 1.20706628889266 0.367816091954023 28.2 28 2 decreased startle reflex 0.000757031096913629 0.0118808508111839 1.20609908834066 0.367521367521368 28.2 28 2 increased circulating LDL cholesterol level 0.024235544400058 0.161192290628728 1.20552666352418 0.36734693877551 28.2 28 2 absent kidney 0.024235544400058 0.161192290628728 1.20552666352418 0.36734693877551 28.2 28 2 reduced fertility 0.000272775823240322 0.0054066124327514 1.20408118790844 0.366906474820144 28.2 28 2 edema 5.98981108846853e-05 0.00161077352243951 1.20202222554881 0.366279069767442 28.2 28 2 sparse hair 0.00477546930511145 0.0481905878152728 1.2006261486318 0.365853658536585 28.2 28 2 palatal shelves fail to meet at midline 0.039103249476194 0.224906337274796 1.2006261486318 0.365853658536585 28.2 28 2 cachexia 0.00167786493709357 0.022494332824596 1.19908688433868 0.365384615384615 28.2 28 2 abnormal hair follicle morphology 0.0128260431746007 0.0986813127423095 1.19808514090983 0.365079365079365 28.2 28 2 gliosis 0.0128260431746007 0.0986813127423095 1.19808514090983 0.365079365079365 28.2 28 2 kidney cysts 0.00748453051380977 0.0694692897503798 1.19738121309496 0.364864864864865 28.2 28 2 abnormal motor capabilities/coordination/movement 0.000512247736722794 0.00886117696647777 1.19334962651888 0.363636363636364 28.2 28 2 teratozoospermia 0.00405806344298418 0.04223612056244 1.19334962651888 0.363636363636364 28.2 28 2 decreased circulating calcium level 0.0203700685806352 0.13877167428958 1.19334962651888 0.363636363636364 28.2 28 2 enlarged pericardium 0.0640296175160818 0.285949144652161 1.19334962651888 0.363636363636364 28.2 28 2 single kidney 0.0640296175160818 0.285949144652161 1.19334962651888 0.363636363636364 28.2 28 2 abnormal enterocyte morphology 0.119291071759391 0.446220362408249 1.19334962651888 0.363636363636364 28.2 28 2 increased activated T cell number 0.119291071759391 0.446220362408249 1.19334962651888 0.363636363636364 28.2 28 2 abnormal oogenesis 0.119291071759391 0.446220362408249 1.19334962651888 0.363636363636364 28.2 28 2 abnormal chorion morphology 0.119291071759391 0.446220362408249 1.19334962651888 0.363636363636364 28.2 28 2 increased myocardial infarction size 0.119291071759391 0.446220362408249 1.19334962651888 0.363636363636364 28.2 28 2 abnormal cochlear sensory epithelium morphology 0.119291071759391 0.446220362408249 1.19334962651888 0.363636363636364 28.2 28 2 abnormal channel response 0.119291071759391 0.446220362408249 1.19334962651888 0.363636363636364 28.2 28 2 abnormal retinal layer morphology 0.119291071759391 0.446220362408249 1.19334962651888 0.363636363636364 28.2 28 2 decreased circulating estradiol level 0.119291071759391 0.446220362408249 1.19334962651888 0.363636363636364 28.2 28 2 rough coat 0.119291071759391 0.446220362408249 1.19334962651888 0.363636363636364 28.2 28 2 abnormal enzyme/coenzyme activity 0.000171392699738709 0.00389350995981771 1.19144938826009 0.363057324840764 28.2 28 2 abnormal spermiogenesis 0.0186725267699683 0.130839184057172 1.18820587812871 0.362068965517241 28.2 28 2 glomerulosclerosis 0.0186725267699683 0.130839184057172 1.18820587812871 0.362068965517241 28.2 28 2 increased respiratory quotient 0.0326279673722088 0.196280698520845 1.1870020221225 0.361702127659574 28.2 28 2 cochlear outer hair cell degeneration 0.00994950404106787 0.084325012954536 1.18506247633472 0.361111111111111 28.2 28 2 heart right ventricle hypertrophy 0.0581658314256363 0.266459494790553 1.18506247633472 0.361111111111111 28.2 28 2 abnormal pharyngeal arch morphology 0.0581658314256363 0.266459494790553 1.18506247633472 0.361111111111111 28.2 28 2 narrow eye opening 0.0581658314256363 0.266459494790553 1.18506247633472 0.361111111111111 28.2 28 2 abnormal cardiovascular system physiology 0.000621986729223716 0.0103491102939398 1.18437707293603 0.360902255639098 28.2 28 2 abnormal myocardial fiber morphology 0.00317460541210026 0.0354782964108474 1.18412269641693 0.360824742268041 28.2 28 2 hypoactivity 1.54281106726737e-08 1.300929671128e-06 1.18385347564473 0.360742705570292 28.2 28 2 kyphosis 0.000318681388646342 0.00614511592447887 1.18141613025369 0.36 28.2 28 2 increased body length 0.0298101811518829 0.181302752115669 1.18141613025369 0.36 28.2 28 2 kidney inflammation 0.0298101811518829 0.181302752115669 1.18141613025369 0.36 28.2 28 2 increased circulating chloride level 0.0298101811518829 0.181302752115669 1.18141613025369 0.36 28.2 28 2 spontaneous skin ulceration 0.107225888081233 0.407523906191088 1.18141613025369 0.36 28.2 28 2 abnormal egg cylinder morphology 0.107225888081233 0.407523906191088 1.18141613025369 0.36 28.2 28 2 abnormal preimplantation embryo development 0.107225888081233 0.407523906191088 1.18141613025369 0.36 28.2 28 2 decreased circulating HDL cholesterol level 0.000883970919828236 0.0132064724508873 1.17936506058311 0.359375 28.2 28 2 decreased eosinophil cell number 0.0156894579535851 0.116612352047085 1.17936506058311 0.359375 28.2 28 2 increased sacral vertebrae number 0.0156894579535851 0.116612352047085 1.17936506058311 0.359375 28.2 28 2 increased rib number 0.00839634135926513 0.0755367057185244 1.17805027233274 0.358974358974359 28.2 28 2 increased urine protein level 0.00839634135926513 0.0755367057185244 1.17805027233274 0.358974358974359 28.2 28 2 abnormal skeleton development 0.00771281907185126 0.0709811150942452 1.17493373722075 0.358024691358025 28.2 28 2 increased circulating cholesterol level 0.000129123189747207 0.00308041463048325 1.17470353860452 0.357954545454545 28.2 28 2 male infertility 1.68348581469424e-10 1.99412903050091e-08 1.17436991078896 0.357852882703777 28.2 28 2 enlarged heart 1.26869108460083e-05 0.000442159201445232 1.17406057005575 0.357758620689655 28.2 28 2 postnatal lethality, incomplete penetrance 1.34472637338026e-11 1.96765109046081e-09 1.17286519190874 0.357394366197183 28.2 28 2 abnormal circulating cholesterol level 0.0965595938279348 0.374422431250176 1.17203981175962 0.357142857142857 28.2 28 2 reddish skin 0.0965595938279348 0.374422431250176 1.17203981175962 0.357142857142857 28.2 28 2 abnormal somite shape 0.0965595938279348 0.374422431250176 1.17203981175962 0.357142857142857 28.2 28 2 abnormal respiration 0.0965595938279348 0.374422431250176 1.17203981175962 0.357142857142857 28.2 28 2 abnormal spleen germinal center morphology 0.0965595938279348 0.374422431250176 1.17203981175962 0.357142857142857 28.2 28 2 increased aggression towards males 0.211858874009452 0.539606538407382 1.17203981175962 0.357142857142857 28.2 28 2 absent visceral yolk sac blood islands 0.211858874009452 0.539606538407382 1.17203981175962 0.357142857142857 28.2 28 2 absent otoliths 0.211858874009452 0.539606538407382 1.17203981175962 0.357142857142857 28.2 28 2 abnormal ventral body wall morphology 0.211858874009452 0.539606538407382 1.17203981175962 0.357142857142857 28.2 28 2 failure of zygotic cell division 0.211858874009452 0.539606538407382 1.17203981175962 0.357142857142857 28.2 28 2 absent olfactory bulb 0.211858874009452 0.539606538407382 1.17203981175962 0.357142857142857 28.2 28 2 abnormal voluntary movement 0.211858874009452 0.539606538407382 1.17203981175962 0.357142857142857 28.2 28 2 abnormal imprinting 0.211858874009452 0.539606538407382 1.17203981175962 0.357142857142857 28.2 28 2 abnormal sagittal suture morphology 0.211858874009452 0.539606538407382 1.17203981175962 0.357142857142857 28.2 28 2 abnormal decidualization 0.211858874009452 0.539606538407382 1.17203981175962 0.357142857142857 28.2 28 2 skeletal muscle necrosis 0.211858874009452 0.539606538407382 1.17203981175962 0.357142857142857 28.2 28 2 abnormal glucose tolerance 0.211858874009452 0.539606538407382 1.17203981175962 0.357142857142857 28.2 28 2 sternebra fusion 0.211858874009452 0.539606538407382 1.17203981175962 0.357142857142857 28.2 28 2 increased lung compliance 0.211858874009452 0.539606538407382 1.17203981175962 0.357142857142857 28.2 28 2 testis degeneration 0.211858874009452 0.539606538407382 1.17203981175962 0.357142857142857 28.2 28 2 spina bifida 0.0480821043270252 0.251738685884691 1.17203981175961 0.357142857142857 28.2 28 2 abnormal retina morphology 3.44474085495824e-05 0.00101484210318709 1.17203981175961 0.357142857142857 28.2 28 2 polydactyly 0.00384627824669502 0.0407722028324445 1.17203981175961 0.357142857142857 28.2 28 2 cardiac hypertrophy 0.00384627824669502 0.0407722028324445 1.17203981175961 0.357142857142857 28.2 28 2 hydroencephaly 0.00193739687971721 0.0249703354315884 1.17000148165221 0.356521739130435 28.2 28 2 abnormal skeleton morphology 0.00193739687971721 0.0249703354315884 1.17000148165221 0.356521739130435 28.2 28 2 abnormal pulmonary alveolus morphology 0.00353809203782677 0.0386008944916407 1.16971894084524 0.356435643564356 28.2 28 2 increased hemoglobin content 0.0227610171923283 0.153117222889184 1.16806679544857 0.355932203389831 28.2 28 2 decreased insulin secretion 0.00597835682661262 0.0585478842763736 1.16683074592957 0.355555555555556 28.2 28 2 abnormal ovarian follicle morphology 0.0437527212031215 0.232261724098455 1.16683074592957 0.355555555555556 28.2 28 2 abnormal ectoderm development 0.0437527212031215 0.232261724098455 1.16683074592957 0.355555555555556 28.2 28 2 increased circulating corticosterone level 0.0437527212031215 0.232261724098455 1.16683074592957 0.355555555555556 28.2 28 2 abnormal metabolism 0.0437527212031215 0.232261724098455 1.16683074592957 0.355555555555556 28.2 28 2 infertility 0.00299365887610828 0.0337869103458341 1.16546762589928 0.355140186915888 28.2 28 2 decreased circulating glucose level 2.99209546589077e-06 0.000128324783989712 1.16447826458697 0.354838709677419 28.2 28 2 abnormal placenta labyrinth morphology 0.010162980610543 0.0859878036351215 1.16313824356904 0.354430379746835 28.2 28 2 weight loss 0.000201753296385681 0.00428941303213147 1.16266349326554 0.354285714285714 28.2 28 2 retinal degeneration 0.00504515026507672 0.05060407775959 1.16227281332828 0.354166666666667 28.2 28 2 abnormal lymph node morphology 0.0398344081898384 0.225765940962159 1.16227281332828 0.354166666666667 28.2 28 2 decreased body length 4.19114381947117e-06 0.000170909348375976 1.16177376961282 0.354014598540146 28.2 28 2 neonatal lethality, incomplete penetrance 7.45233763778169e-06 0.000289651404280968 1.16122098272799 0.353846153846154 28.2 28 2 increased sensitivity to induced morbidity/mortality 0.000158272188357779 0.00367945858448576 1.15930024858831 0.353260869565217 28.2 28 2 microphthalmia 0.000554267630101574 0.00944342965669633 1.15825110809185 0.352941176470588 28.2 28 2 abnormal gastrulation 0.0362855033265793 0.213886705035227 1.15825110809185 0.352941176470588 28.2 28 2 cochlear inner hair cell degeneration 0.0362855033265793 0.213886705035227 1.15825110809185 0.352941176470588 28.2 28 2 abnormal trophoblast layer morphology 0.0362855033265793 0.213886705035227 1.15825110809185 0.352941176470588 28.2 28 2 abnormal thrombosis 0.0362855033265793 0.213886705035227 1.15825110809185 0.352941176470588 28.2 28 2 decreased regulatory T cell number 0.0786744983625314 0.339121129690489 1.15825110809185 0.352941176470588 28.2 28 2 decreased osteoblast cell number 0.0786744983625314 0.339121129690489 1.15825110809185 0.352941176470588 28.2 28 2 increased susceptibility to weight gain 0.0786744983625314 0.339121129690489 1.15825110809185 0.352941176470588 28.2 28 2 hydroureter 0.186628515012724 0.539606538407382 1.15825110809185 0.352941176470588 28.2 28 2 abnormal cranial suture morphology 0.186628515012724 0.539606538407382 1.15825110809185 0.352941176470588 28.2 28 2 abnormal glutamate-mediated receptor currents 0.186628515012724 0.539606538407382 1.15825110809185 0.352941176470588 28.2 28 2 decreased vasoconstriction 0.186628515012724 0.539606538407382 1.15825110809185 0.352941176470588 28.2 28 2 absence seizures 0.186628515012724 0.539606538407382 1.15825110809185 0.352941176470588 28.2 28 2 aminoaciduria 0.186628515012724 0.539606538407382 1.15825110809185 0.352941176470588 28.2 28 2 abnormal testis development 0.186628515012724 0.539606538407382 1.15825110809185 0.352941176470588 28.2 28 2 abnormal circulating chemokine level 0.186628515012724 0.539606538407382 1.15825110809185 0.352941176470588 28.2 28 2 abnormal ductus venosus valve morphology 0.186628515012724 0.539606538407382 1.15825110809185 0.352941176470588 28.2 28 2 increased heart weight 0.00100060055732116 0.0144289500657181 1.15686231779438 0.352517985611511 28.2 28 2 hyperglycemia 0.00784056207216263 0.0713104137276217 1.15605745069017 0.352272727272727 28.2 28 2 increased liver weight 0.00784056207216263 0.0713104137276217 1.15605745069017 0.352272727272727 28.2 28 2 small kidney 0.00784056207216263 0.0713104137276217 1.15605745069017 0.352272727272727 28.2 28 2 no abnormal phenotype detected 1.3793664032431e-30 3.43117392806721e-27 1.15569205184919 0.352161383285303 28.2 28 2 perinatal lethality, complete penetrance 5.90659573937951e-05 0.00159702792409854 1.15553220877709 0.352112676056338 28.2 28 2 improved glucose tolerance 0.000114460008525028 0.00280511597247297 1.15529638587733 0.352040816326531 28.2 28 2 neurodegeneration 0.0330688179612005 0.198452797776806 1.15467625899281 0.351851851851852 28.2 28 2 abnormal locomotor activation 0.00719251971983838 0.0668995367325419 1.15400843004024 0.351648351648352 28.2 28 2 increased brown adipose tissue amount 0.0711584966016956 0.312456770161903 1.15303376075811 0.351351351351351 28.2 28 2 abnormal long bone metaphysis morphology 0.0711584966016956 0.312456770161903 1.15303376075811 0.351351351351351 28.2 28 2 impaired skeletal muscle contractility 0.0711584966016956 0.312456770161903 1.15303376075811 0.351351351351351 28.2 28 2 abnormal respiratory electron transport chain 0.0711584966016956 0.312456770161903 1.15303376075811 0.351351351351351 28.2 28 2 abnormal hepatocyte morphology 0.00330312744890595 0.0366837712087301 1.15303376075811 0.351351351351351 28.2 28 2 incomplete embryo turning 0.0301511687358272 0.182929346903342 1.15147770979892 0.350877192982456 28.2 28 2 abnormal facial morphology 0.0301511687358272 0.182929346903342 1.15147770979892 0.350877192982456 28.2 28 2 decreased circulating phosphate level 0.0644347629745219 0.287242782973339 1.14859901552442 0.35 28.2 28 2 perinatal lethality 0.0644347629745219 0.287242782973339 1.14859901552442 0.35 28.2 28 2 decreased myocardial infarction size 0.165383319451403 0.52033884699506 1.14859901552442 0.35 28.2 28 2 abnormal physiological neovascularization 0.165383319451403 0.52033884699506 1.14859901552442 0.35 28.2 28 2 abnormal optic stalk morphology 0.165383319451403 0.52033884699506 1.14859901552442 0.35 28.2 28 2 abnormal heart electrocardiography waveform feature 0.165383319451403 0.52033884699506 1.14859901552442 0.35 28.2 28 2 abnormal eating behavior 0.0275029367547754 0.173638464917522 1.14859901552442 0.35 28.2 28 2 postnatal lethality, complete penetrance 1.42319616114705e-07 9.5681093266305e-06 1.14774883120501 0.349740932642487 28.2 28 2 skin lesions 0.0250976654795231 0.164507095863804 1.1459944826094 0.349206349206349 28.2 28 2 increased circulating creatinine level 0.0102506025425102 0.0865819145144112 1.14478307195125 0.348837209302326 28.2 28 2 abnormal left-right axis patterning 0.0584069128933208 0.267072051143631 1.14478307195125 0.348837209302326 28.2 28 2 abnormal double-strand DNA break repair 0.0584069128933208 0.267072051143631 1.14478307195125 0.348837209302326 28.2 28 2 abnormal renal glomerulus morphology 0.00429594690209914 0.0438856998725733 1.14408289881856 0.348623853211009 28.2 28 2 increased startle reflex 0.00939070020166848 0.0816857890551199 1.14306804113185 0.348314606741573 28.2 28 2 abnormal muscle physiology 0.00939070020166848 0.0816857890551199 1.14306804113185 0.348314606741573 28.2 28 2 abnormal rib morphology 0.00168198830366829 0.022494332824596 1.14252177205604 0.348148148148148 28.2 28 2 abnormal regulatory T cell physiology 0.147222452018461 0.473354639344763 1.14146486014849 0.347826086956522 28.2 28 2 abnormal ulna morphology 0.147222452018461 0.473354639344763 1.14146486014849 0.347826086956522 28.2 28 2 increased susceptibility to fungal infection 0.147222452018461 0.473354639344763 1.14146486014849 0.347826086956522 28.2 28 2 abnormal chondrocyte physiology 0.147222452018461 0.473354639344763 1.14146486014849 0.347826086956522 28.2 28 2 abnormal palatal shelf fusion at midline 0.147222452018461 0.473354639344763 1.14146486014849 0.347826086956522 28.2 28 2 abnormal basicranium morphology 0.147222452018461 0.473354639344763 1.14146486014849 0.347826086956522 28.2 28 2 organ of Corti degeneration 0.0481213045781591 0.251738685884691 1.13855295999505 0.346938775510204 28.2 28 2 abnormal long bone hypertrophic chondrocyte zone 0.0481213045781591 0.251738685884691 1.13855295999505 0.346938775510204 28.2 28 2 decreased circulating creatinine level 0.0481213045781591 0.251738685884691 1.13855295999505 0.346938775510204 28.2 28 2 abnormal excitatory postsynaptic currents 0.0159689948672123 0.11734970378786 1.13597704832086 0.346153846153846 28.2 28 2 abnormal heart ventricle morphology 0.0159689948672123 0.11734970378786 1.13597704832086 0.346153846153846 28.2 28 2 absent gastric milk in neonates 0.0159689948672123 0.11734970378786 1.13597704832086 0.346153846153846 28.2 28 2 distended pericardium 0.0437317510562983 0.232261724098455 1.13597704832086 0.346153846153846 28.2 28 2 abnormal snout morphology 0.0437317510562983 0.232261724098455 1.13597704832086 0.346153846153846 28.2 28 2 abnormal nasal bone morphology 0.131527023914975 0.464395062260441 1.13597704832086 0.346153846153846 28.2 28 2 abnormal ureter morphology 0.131527023914975 0.464395062260441 1.13597704832086 0.346153846153846 28.2 28 2 increased susceptibility to otitis media 0.131527023914975 0.464395062260441 1.13597704832086 0.346153846153846 28.2 28 2 abnormal head morphology 0.039770935689832 0.225765940962159 1.13368214519294 0.345454545454545 28.2 28 2 abnormal learning/memory/conditioning 0.039770935689832 0.225765940962159 1.13368214519294 0.345454545454545 28.2 28 2 increased anxiety-related response 0.00183415119895998 0.0238871785728426 1.13325288273735 0.345323741007194 28.2 28 2 decreased exploration in new environment 0.0133565936519797 0.102072278676803 1.13297181803429 0.345238095238095 28.2 28 2 hyperactivity 6.81181601170411e-07 3.68356354980739e-05 1.13223468607721 0.345013477088949 28.2 28 2 abnormal circulating glucose level 0.117848858344045 0.444501948644141 1.13162464583687 0.344827586206897 28.2 28 2 abnormal maternal nurturing 0.0329560602345879 0.198014975443327 1.12976952346665 0.344262295081967 28.2 28 2 decreased circulating cholesterol level 0.000440625947644547 0.00803755260050935 1.12976952346664 0.344262295081967 28.2 28 2 small testis 1.92418045301067e-05 0.000621610243748577 1.12957460118861 0.344202898550725 28.2 28 2 kidney cortex cysts 0.105850451419606 0.403220517467489 1.12808831881863 0.34375 28.2 28 2 abnormal lymphatic vessel morphology 0.105850451419606 0.403220517467489 1.12808831881863 0.34375 28.2 28 2 abnormal heart atrium morphology 0.105850451419606 0.403220517467489 1.12808831881863 0.34375 28.2 28 2 bradykinesia 0.105850451419606 0.403220517467489 1.12808831881863 0.34375 28.2 28 2 cleft palate 0.00280017658130323 0.0337181294398785 1.12730546779932 0.343511450381679 28.2 28 2 abnormal neuron morphology 0.0085841401116296 0.0768029635009099 1.12705242504561 0.343434343434343 28.2 28 2 decreased compact bone thickness 0.0273702396570566 0.173119887422182 1.12655766981073 0.343283582089552 28.2 28 2 abnormal gait 7.82213440200531e-06 0.000297061974427301 1.12576510074516 0.343042071197411 28.2 28 2 impaired adaptive thermogenesis 0.0952699006529816 0.370866788535668 1.12515821928923 0.342857142857143 28.2 28 2 increased or absent threshold for auditory brainstem response 1.62970815391286e-05 0.000547824193629492 1.12418489903033 0.342560553633218 28.2 28 2 abnormal fertility/fecundity 0.022775225113165 0.153117222889184 1.12387379209826 0.342465753424658 28.2 28 2 increased grooming behavior 0.0858991194261462 0.353861745054054 1.12269076705395 0.342105263157895 28.2 28 2 impaired branching involved in ureteric bud morphogenesis 0.0858991194261462 0.353861745054054 1.12269076705395 0.342105263157895 28.2 28 2 increased tumor growth/size 0.0775696218255067 0.336450626488139 1.12058440538968 0.341463414634146 28.2 28 2 decreased sensitivity to induced morbidity/mortality 0.0701428658833228 0.309088359406139 1.11876527486145 0.340909090909091 28.2 28 2 abnormal liver morphology 0.00072155693845563 0.0115425908965169 1.11834860250582 0.340782122905028 28.2 28 2 small ovary 0.0132456981571203 0.101380535894883 1.11794566660148 0.340659340659341 28.2 28 2 increased thermal nociceptive threshold 0.0132456981571203 0.101380535894883 1.11794566660148 0.340659340659341 28.2 28 2 abnormal tibia morphology 0.0635034695321724 0.284109497232516 1.11717837376236 0.340425531914894 28.2 28 2 hepatic necrosis 0.0635034695321724 0.284109497232516 1.11717837376236 0.340425531914894 28.2 28 2 abnormal coat/ hair morphology 0.052212880998835 0.257439783365305 1.11454351910726 0.339622641509434 28.2 28 2 abnormal pancreatic islet morphology 0.052212880998835 0.257439783365305 1.11454351910726 0.339622641509434 28.2 28 2 abnormal seminal vesicle morphology 0.0474085719364162 0.249057703678638 1.11343782117163 0.339285714285714 28.2 28 2 decreased liver weight 0.0295721511889952 0.180517119221167 1.109310920426 0.338028169014085 28.2 28 2 abnormal lipid level 0.0204723881721137 0.138949701441017 1.10708338845727 0.337349397590361 28.2 28 2 abnormal lens morphology 0.00540330826360209 0.053978832553053 1.10244994793639 0.3359375 28.2 28 2 abnormal cranium morphology 0.00454131525094162 0.0462025426859602 1.10206728568441 0.335820895522388 28.2 28 2 increased body weight 0.000354405782573294 0.00667866957690204 1.09878732352464 0.334821428571429 28.2 28 2 abnormal chondrocyte morphology 0.0617849125176523 0.27691886466245 1.09390382430897 0.333333333333333 28.2 28 2 abnormal long bone epiphyseal plate proliferative zone 0.0617849125176523 0.27691886466245 1.09390382430897 0.333333333333333 28.2 28 2 abnormal brain commissure morphology 0.158433656477864 0.501404224540313 1.09390382430897 0.333333333333333 28.2 28 2 abnormal type II pneumocyte morphology 0.158433656477864 0.501404224540313 1.09390382430897 0.333333333333333 28.2 28 2 abnormal palate morphology 0.158433656477864 0.501404224540313 1.09390382430897 0.333333333333333 28.2 28 2 abnormal bone trabecula morphology 0.158433656477864 0.501404224540313 1.09390382430897 0.333333333333333 28.2 28 2 increased incidence of induced tumors 0.200851690087889 0.539606538407382 1.09390382430897 0.333333333333333 28.2 28 2 increased vasoconstriction 0.200851690087889 0.539606538407382 1.09390382430897 0.333333333333333 28.2 28 2 dry skin 0.200851690087889 0.539606538407382 1.09390382430897 0.333333333333333 28.2 28 2 abnormal embryonic/fetal subventricular zone morphology 0.200851690087889 0.539606538407382 1.09390382430897 0.333333333333333 28.2 28 2 embryonic lethality at implantation, complete penetrance 0.200851690087889 0.539606538407382 1.09390382430897 0.333333333333333 28.2 28 2 increased susceptibility to parasitic infection 0.020022868298263 0.13877167428958 1.09390382430897 0.333333333333333 28.2 28 2 abnormal limb morphology 0.0316992347250566 0.190924567502611 1.09390382430897 0.333333333333333 28.2 28 2 abnormal forebrain development 0.0348006271477972 0.207097033564942 1.09390382430897 0.333333333333333 28.2 28 2 distended abdomen 0.0681887096697078 0.301010497432827 1.09390382430897 0.333333333333333 28.2 28 2 abnormal cued conditioning behavior 0.0681887096697078 0.301010497432827 1.09390382430897 0.333333333333333 28.2 28 2 abnormal cervical vertebrae morphology 0.0681887096697078 0.301010497432827 1.09390382430897 0.333333333333333 28.2 28 2 increased kidney weight 0.0681887096697078 0.301010497432827 1.09390382430897 0.333333333333333 28.2 28 2 abnormal intestinal epithelium morphology 0.0753380002033398 0.327628104031132 1.09390382430897 0.333333333333333 28.2 28 2 cardiomyopathy 0.0833379382234237 0.353861745054054 1.09390382430897 0.333333333333333 28.2 28 2 abnormal iris morphology 0.102414099407148 0.396197624067309 1.09390382430897 0.333333333333333 28.2 28 2 reduced long term depression 0.113821935266654 0.430946824925118 1.09390382430897 0.333333333333333 28.2 28 2 abnormal tooth development 0.126760868371368 0.464395062260441 1.09390382430897 0.333333333333333 28.2 28 2 abnormal aorta morphology 0.126760868371368 0.464395062260441 1.09390382430897 0.333333333333333 28.2 28 2 abnormal ovarian folliculogenesis 0.126760868371368 0.464395062260441 1.09390382430897 0.333333333333333 28.2 28 2 dilated heart atrium 0.126760868371368 0.464395062260441 1.09390382430897 0.333333333333333 28.2 28 2 abnormal digestive system morphology 0.177999515177513 0.539606538407382 1.09390382430897 0.333333333333333 28.2 28 2 cortical renal glomerulopathies 0.227902456899687 0.539606538407382 1.09390382430897 0.333333333333333 28.2 28 2 right pulmonary isomerism 0.227902456899687 0.539606538407382 1.09390382430897 0.333333333333333 28.2 28 2 decreased body height 0.177999515177513 0.539606538407382 1.09390382430897 0.333333333333333 28.2 28 2 abnormal body weight 0.177999515177513 0.539606538407382 1.09390382430897 0.333333333333333 28.2 28 2 ocular hypertelorism 0.177999515177513 0.539606538407382 1.09390382430897 0.333333333333333 28.2 28 2 abnormal metacarpal bone morphology 0.227902456899687 0.539606538407382 1.09390382430897 0.333333333333333 28.2 28 2 absent allantois 0.227902456899687 0.539606538407382 1.09390382430897 0.333333333333333 28.2 28 2 increased circulating renin level 0.227902456899687 0.539606538407382 1.09390382430897 0.333333333333333 28.2 28 2 increased circulating glycerol level 0.227902456899687 0.539606538407382 1.09390382430897 0.333333333333333 28.2 28 2 absent ureter 0.227902456899687 0.539606538407382 1.09390382430897 0.333333333333333 28.2 28 2 abnormal osteoblast morphology 0.177999515177513 0.539606538407382 1.09390382430897 0.333333333333333 28.2 28 2 decreased fatty acid level 0.177999515177513 0.539606538407382 1.09390382430897 0.333333333333333 28.2 28 2 increased susceptibility to autoimmune disorder 0.227902456899687 0.539606538407382 1.09390382430897 0.333333333333333 28.2 28 2 abnormal sperm axoneme morphology 0.227902456899687 0.539606538407382 1.09390382430897 0.333333333333333 28.2 28 2 abnormal lung saccule morphology 0.177999515177513 0.539606538407382 1.09390382430897 0.333333333333333 28.2 28 2 impaired leukocyte tethering or rolling 0.227902456899687 0.539606538407382 1.09390382430897 0.333333333333333 28.2 28 2 increased adipocyte glucose uptake 0.227902456899687 0.539606538407382 1.09390382430897 0.333333333333333 28.2 28 2 abnormal kidney development 0.05086932591337 0.257439783365305 1.09390382430897 0.333333333333333 28.2 28 2 abnormal incisor morphology 0.05086932591337 0.257439783365305 1.09390382430897 0.333333333333333 28.2 28 2 salivary gland inflammation 0.141511629326593 0.466989027306025 1.09390382430897 0.333333333333333 28.2 28 2 disorganized myocardium 0.141511629326593 0.466989027306025 1.09390382430897 0.333333333333333 28.2 28 2 abnormal brain vasculature morphology 0.141511629326593 0.466989027306025 1.09390382430897 0.333333333333333 28.2 28 2 absent incisors 0.260524406276757 0.585944358601657 1.09390382430897 0.333333333333333 28.2 28 2 hyperpigmentation 0.260524406276757 0.585944358601657 1.09390382430897 0.333333333333333 28.2 28 2 audiogenic seizures 0.260524406276757 0.585944358601657 1.09390382430897 0.333333333333333 28.2 28 2 increased airway responsiveness 0.260524406276757 0.585944358601657 1.09390382430897 0.333333333333333 28.2 28 2 abnormal respiratory system morphology 0.260524406276757 0.585944358601657 1.09390382430897 0.333333333333333 28.2 28 2 abnormal bronchus morphology 0.260524406276757 0.585944358601657 1.09390382430897 0.333333333333333 28.2 28 2 joint inflammation 0.260524406276757 0.585944358601657 1.09390382430897 0.333333333333333 28.2 28 2 decreased aggression towards males 0.260524406276757 0.585944358601657 1.09390382430897 0.333333333333333 28.2 28 2 abnormal secondary palate development 0.260524406276757 0.585944358601657 1.09390382430897 0.333333333333333 28.2 28 2 abnormal aorta wall morphology 0.260524406276757 0.585944358601657 1.09390382430897 0.333333333333333 28.2 28 2 liver vascular congestion 0.260524406276757 0.585944358601657 1.09390382430897 0.333333333333333 28.2 28 2 ostium primum atrial septal defect 0.260524406276757 0.585944358601657 1.09390382430897 0.333333333333333 28.2 28 2 abnormal microglial cell activation 0.260524406276757 0.585944358601657 1.09390382430897 0.333333333333333 28.2 28 2 abnormal branching involved in lung morphogenesis 0.260524406276757 0.585944358601657 1.09390382430897 0.333333333333333 28.2 28 2 neonatal lethality, complete penetrance 1.17656241283275e-06 5.9728551059622e-05 1.08670708862273 0.331140350877193 28.2 28 2 respiratory failure 0.00399019009541945 0.0417919909993932 1.0866594281215 0.33112582781457 28.2 28 2 increased circulating triglyceride level 0.00474370071236006 0.047967298869901 1.08635966000339 0.331034482758621 28.2 28 2 abnormal vertebrae morphology 0.0136021238769919 0.103789212098213 1.08386800940706 0.330275229357798 28.2 28 2 decreased heart rate 0.0177973019719794 0.127214909929019 1.08296478606588 0.33 28.2 28 2 dehydration 0.0447192017120824 0.236930807792982 1.07827662681885 0.328571428571429 28.2 28 2 abnormal male meiosis 0.0596075042932634 0.271699393396776 1.07597097473014 0.327868852459016 28.2 28 2 increased sensitivity to xenobiotic induced morbidity/mortality 0.0157715543931504 0.116612352047085 1.07401466386699 0.327272727272727 28.2 28 2 abnormal contextual conditioning behavior 0.0724944147582136 0.317315677024604 1.07401466386699 0.327272727272727 28.2 28 2 abnormal joint morphology 0.0724944147582136 0.317315677024604 1.07401466386699 0.327272727272727 28.2 28 2 eyelids open at birth 0.0800678038533637 0.342902576306799 1.07286721230303 0.326923076923077 28.2 28 2 abnormal brain wave pattern 0.0800678038533637 0.342902576306799 1.07286721230303 0.326923076923077 28.2 28 2 decreased body temperature 0.0800678038533637 0.342902576306799 1.07286721230303 0.326923076923077 28.2 28 2 abnormal respiratory system physiology 0.0885339738397907 0.359850097919084 1.07157925646593 0.326530612244898 28.2 28 2 abnormal craniofacial development 0.0885339738397907 0.359850097919084 1.07157925646593 0.326530612244898 28.2 28 2 alopecia 0.0247453707313531 0.163788937930364 1.070874270113 0.326315789473684 28.2 28 2 delayed wound healing 0.0980211372252925 0.379793736523232 1.07012330638921 0.326086956521739 28.2 28 2 abnormal male reproductive system morphology 0.108682020145091 0.412113605352003 1.06846420048783 0.325581395348837 28.2 28 2 abnormal blood circulation 0.108682020145091 0.412113605352003 1.06846420048783 0.325581395348837 28.2 28 2 kidney failure 0.108682020145091 0.412113605352003 1.06846420048783 0.325581395348837 28.2 28 2 head bobbing 0.120700446578412 0.45115305914921 1.06655622870125 0.325 28.2 28 2 abnormal intestine morphology 0.0472833752099987 0.248980187657483 1.06433885608441 0.324324324324324 28.2 28 2 abnormal pancreatic beta cell physiology 0.134300385825834 0.464395062260441 1.06433885608441 0.324324324324324 28.2 28 2 abnormal hair follicle development 0.134300385825834 0.464395062260441 1.06433885608441 0.324324324324324 28.2 28 2 atelectasis 0.051977163421062 0.257439783365305 1.06308963207492 0.323943661971831 28.2 28 2 decreased litter size 0.00033206259694855 0.00632954566980474 1.06276065493363 0.323843416370107 28.2 28 2 kinked tail 0.023840995096188 0.159206645105417 1.06173018241753 0.323529411764706 28.2 28 2 abnormal endoderm development 0.14975869750603 0.476374373460676 1.06173018241753 0.323529411764706 28.2 28 2 increased width of hypertrophic chondrocyte zone 0.14975869750603 0.476374373460676 1.06173018241753 0.323529411764706 28.2 28 2 deafness 0.0260976322565967 0.169877529624467 1.06075522357234 0.323232323232323 28.2 28 2 cyanosis 0.00288690388222277 0.0337181294398785 1.05971932979932 0.322916666666667 28.2 28 2 abnormal cranial ganglia morphology 0.167423609234439 0.521234327873177 1.05861660416997 0.32258064516129 28.2 28 2 absent mature ovarian follicles 0.167423609234439 0.521234327873177 1.05861660416997 0.32258064516129 28.2 28 2 abnormal eyelid morphology 0.167423609234439 0.521234327873177 1.05861660416997 0.32258064516129 28.2 28 2 abnormal podocyte morphology 0.167423609234439 0.521234327873177 1.05861660416997 0.32258064516129 28.2 28 2 abnormal nervous system physiology 0.0191573196331009 0.134047349050179 1.05585499563736 0.321739130434783 28.2 28 2 absent corpus callosum 0.187742422996251 0.539606538407382 1.05483583058365 0.321428571428571 28.2 28 2 failure of blastocyst to hatch from the zona pellucida 0.187742422996251 0.539606538407382 1.05483583058365 0.321428571428571 28.2 28 2 abnormal hormone level 0.187742422996251 0.539606538407382 1.05483583058365 0.321428571428571 28.2 28 2 abnormal renal tubule epithelium morphology 0.187742422996251 0.539606538407382 1.05483583058365 0.321428571428571 28.2 28 2 testicular atrophy 0.103112640326595 0.398002413845518 1.05014767133661 0.32 28.2 28 2 decreased respiratory quotient 0.103112640326595 0.398002413845518 1.05014767133661 0.32 28.2 28 2 abnormal inner ear vestibule morphology 0.211304751458114 0.539606538407382 1.05014767133661 0.32 28.2 28 2 ruffled hair 0.211304751458114 0.539606538407382 1.05014767133661 0.32 28.2 28 2 abnormal primitive streak morphology 0.211304751458114 0.539606538407382 1.05014767133661 0.32 28.2 28 2 decreased placenta weight 0.211304751458114 0.539606538407382 1.05014767133661 0.32 28.2 28 2 abnormal vertebrae development 0.211304751458114 0.539606538407382 1.05014767133661 0.32 28.2 28 2 abnormal energy expenditure 0.211304751458114 0.539606538407382 1.05014767133661 0.32 28.2 28 2 decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 0.211304751458114 0.539606538407382 1.05014767133661 0.32 28.2 28 2 abnormal trabecular bone morphology 0.0200844936967919 0.13877167428958 1.04794147874977 0.319327731092437 28.2 28 2 increased circulating glucose level 0.0124152763636119 0.0986813127423095 1.04735472540221 0.319148936170213 28.2 28 2 increased bone mineral density 0.0239902965150592 0.159988907724423 1.04550100022451 0.31858407079646 28.2 28 2 abnormal tail morphology 0.0727009081878975 0.317315677024604 1.04418092320402 0.318181818181818 28.2 28 2 abnormal circadian rhythm 0.126666958800583 0.464395062260441 1.04418092320402 0.318181818181818 28.2 28 2 abnormal photoreceptor outer segment morphology 0.126666958800583 0.464395062260441 1.04418092320402 0.318181818181818 28.2 28 2 decreased susceptibility to hepatic steatosis 0.0800910138027137 0.342902576306799 1.04181316600855 0.317460317460317 28.2 28 2 decreased cardiac muscle contractility 0.0313831512988997 0.189292306719499 1.04131229429412 0.317307692307692 28.2 28 2 thick ventricular wall 0.140725472356546 0.466989027306025 1.04054266214756 0.317073170731707 28.2 28 2 short humerus 0.140725472356546 0.466989027306025 1.04054266214756 0.317073170731707 28.2 28 2 abnormal cholesterol homeostasis 0.140725472356546 0.466989027306025 1.04054266214756 0.317073170731707 28.2 28 2 decreased birth weight 0.0411720972304828 0.225765940962159 1.03632993881903 0.315789473684211 28.2 28 2 abnormal frontal bone morphology 0.15663943185646 0.496990544314979 1.03632993881903 0.315789473684211 28.2 28 2 abnormal reproductive system physiology 0.15663943185646 0.496990544314979 1.03632993881903 0.315789473684211 28.2 28 2 hyporesponsive to tactile stimuli 0.15663943185646 0.496990544314979 1.03632993881903 0.315789473684211 28.2 28 2 irregular coat pigmentation 0.271706894876639 0.606706374331814 1.03632993881903 0.315789473684211 28.2 28 2 flaky skin 0.271706894876639 0.606706374331814 1.03632993881903 0.315789473684211 28.2 28 2 thin dermal layer 0.271706894876639 0.606706374331814 1.03632993881903 0.315789473684211 28.2 28 2 short vibrissae 0.271706894876639 0.606706374331814 1.03632993881903 0.315789473684211 28.2 28 2 abnormal nasal septum morphology 0.271706894876639 0.606706374331814 1.03632993881903 0.315789473684211 28.2 28 2 abnormal metatarsal bone morphology 0.271706894876639 0.606706374331814 1.03632993881903 0.315789473684211 28.2 28 2 abnormal optic vesicle formation 0.271706894876639 0.606706374331814 1.03632993881903 0.315789473684211 28.2 28 2 abnormal sternebra morphology 0.271706894876639 0.606706374331814 1.03632993881903 0.315789473684211 28.2 28 2 absent amnion 0.271706894876639 0.606706374331814 1.03632993881903 0.315789473684211 28.2 28 2 decreased liver regeneration 0.271706894876639 0.606706374331814 1.03632993881903 0.315789473684211 28.2 28 2 decreased liver glycogen level 0.271706894876639 0.606706374331814 1.03632993881903 0.315789473684211 28.2 28 2 shortened RR interval 0.271706894876639 0.606706374331814 1.03632993881903 0.315789473684211 28.2 28 2 reduced male fertility 0.00373654875988251 0.039891266266986 1.02643839021062 0.312775330396476 28.2 28 2 reduced long term potentiation 0.0340042229762934 0.203575221789482 1.02553483528966 0.3125 28.2 28 2 abnormal urine homeostasis 0.0468966581704164 0.24793929266506 1.02553483528966 0.3125 28.2 28 2 abnormal kidney physiology 0.13186642748058 0.464395062260441 1.02553483528966 0.3125 28.2 28 2 polydipsia 0.195411408241181 0.539606538407382 1.02553483528966 0.3125 28.2 28 2 failure of tooth eruption 0.311390461513883 0.665735945866596 1.02553483528966 0.3125 28.2 28 2 abnormal bone marrow cell number 0.311390461513883 0.665735945866596 1.02553483528966 0.3125 28.2 28 2 abnormal intestinal absorption 0.311390461513883 0.665735945866596 1.02553483528966 0.3125 28.2 28 2 abnormal extraembryonic endoderm formation 0.311390461513883 0.665735945866596 1.02553483528966 0.3125 28.2 28 2 white spotting 0.311390461513883 0.665735945866596 1.02553483528966 0.3125 28.2 28 2 increased pancreatic beta cell number 0.311390461513883 0.665735945866596 1.02553483528966 0.3125 28.2 28 2 bowed radius 0.311390461513883 0.665735945866596 1.02553483528966 0.3125 28.2 28 2 abnormal wound healing 0.311390461513883 0.665735945866596 1.02553483528966 0.3125 28.2 28 2 abnormal pancreatic alpha cell morphology 0.311390461513883 0.665735945866596 1.02553483528966 0.3125 28.2 28 2 decreased midbrain size 0.311390461513883 0.665735945866596 1.02553483528966 0.3125 28.2 28 2 irregular heartbeat 0.146234903577365 0.472414704738566 1.02097690268838 0.311111111111111 28.2 28 2 small placenta 0.146234903577365 0.472414704738566 1.02097690268838 0.311111111111111 28.2 28 2 decreased osteoclast cell number 0.146234903577365 0.472414704738566 1.02097690268838 0.311111111111111 28.2 28 2 stomach inflammation 0.219194527089744 0.539606538407382 1.01846218125318 0.310344827586207 28.2 28 2 absent long term depression 0.219194527089744 0.539606538407382 1.01846218125318 0.310344827586207 28.2 28 2 short sternum 0.219194527089744 0.539606538407382 1.01846218125318 0.310344827586207 28.2 28 2 abnormal skeletal muscle fiber morphology 0.0865219446204266 0.353861745054054 1.01686834372384 0.309859154929577 28.2 28 2 abnormal optic nerve morphology 0.162427444534594 0.513064467656892 1.01576783685833 0.30952380952381 28.2 28 2 abnormal reproductive system morphology 0.162427444534594 0.513064467656892 1.01576783685833 0.30952380952381 28.2 28 2 increased exploration in new environment 0.0741593305979426 0.322784487948175 1.0128739113972 0.308641975308642 28.2 28 2 increased circulating alanine transaminase level 0.081385681006416 0.348145969911367 1.00975737628521 0.307692307692308 28.2 28 2 absent corpus luteum 0.136415671065912 0.464395062260441 1.00975737628521 0.307692307692308 28.2 28 2 increased susceptibility to injury 0.136415671065912 0.464395062260441 1.00975737628521 0.307692307692308 28.2 28 2 abnormal Schwann cell morphology 0.246761519255065 0.560309702553148 1.00975737628521 0.307692307692308 28.2 28 2 abnormal suckling behavior 0.0698215045401446 0.307945022240443 1.00688874737531 0.306818181818182 28.2 28 2 increased fluid intake 0.150983686439752 0.479964115040108 1.00460555293681 0.306122448979592 28.2 28 2 circling 0.076508664138583 0.332428475187293 1.00381762701294 0.305882352941176 28.2 28 2 impaired wound healing 0.201533478814366 0.539606538407382 1.00274517228323 0.305555555555556 28.2 28 2 renal hypoplasia 0.201533478814366 0.539606538407382 1.00274517228323 0.305555555555556 28.2 28 2 short radius 0.201533478814366 0.539606538407382 1.00274517228323 0.305555555555556 28.2 28 2 head tilt 0.201533478814366 0.539606538407382 1.00274517228323 0.305555555555556 28.2 28 2 syndactyly 0.127240247956776 0.464395062260441 1.00120011038448 0.305084745762712 28.2 28 2 abnormal thoracic vertebrae morphology 0.127240247956776 0.464395062260441 1.00120011038448 0.305084745762712 28.2 28 2 abnormal response/metabolism to endogenous compounds 0.0838704702678213 0.353861745054054 1.0005217905265 0.304878048780488 28.2 28 2 abnormal inner ear morphology 0.167328426356396 0.521234327873177 0.998781752629933 0.304347826086957 28.2 28 2 bidirectional circling 0.279028063205298 0.6109622843069 0.998781752629933 0.304347826086957 28.2 28 2 hypotension 0.279028063205298 0.6109622843069 0.998781752629933 0.304347826086957 28.2 28 2 conjunctivitis 0.279028063205298 0.6109622843069 0.998781752629933 0.304347826086957 28.2 28 2 pancreas inflammation 0.279028063205298 0.6109622843069 0.998781752629933 0.304347826086957 28.2 28 2 decreased epididymis weight 0.279028063205298 0.6109622843069 0.998781752629933 0.304347826086957 28.2 28 2 abnormal corneal stroma morphology 0.279028063205298 0.6109622843069 0.998781752629933 0.304347826086957 28.2 28 2 abnormal visceral yolk sac morphology 0.0919804400439148 0.360350439607561 0.996975637344887 0.30379746835443 28.2 28 2 abnormal neuron differentiation 0.0532629130263044 0.257439783365305 0.996233839995673 0.303571428571429 28.2 28 2 abnormal skin morphology 0.118706086991286 0.446220362408249 0.994458022099067 0.303030303030303 28.2 28 2 belly spot 0.225259469054144 0.539606538407382 0.994458022099067 0.303030303030303 28.2 28 2 dextrocardia 0.225259469054144 0.539606538407382 0.994458022099067 0.303030303030303 28.2 28 2 abnormal epidermis stratum basale morphology 0.225259469054144 0.539606538407382 0.994458022099067 0.303030303030303 28.2 28 2 head tossing 0.225259469054144 0.539606538407382 0.994458022099067 0.303030303030303 28.2 28 2 cardiovascular system phenotype 0.225259469054144 0.539606538407382 0.994458022099067 0.303030303030303 28.2 28 2 abnormal social investigation 0.103438366843067 0.398002413845518 0.984513441878077 0.3 28.2 28 2 abnormal action potential 0.121676417114625 0.454459590949896 0.984513441878077 0.3 28.2 28 2 abnormal female reproductive system morphology 0.20647063662598 0.539606538407382 0.984513441878077 0.3 28.2 28 2 waved hair 0.317274141487455 0.675832688722789 0.984513441878077 0.3 28.2 28 2 small gonad 0.317274141487455 0.675832688722789 0.984513441878077 0.3 28.2 28 2 abnormal hearing physiology 0.317274141487455 0.675832688722789 0.984513441878077 0.3 28.2 28 2 abnormal hyoid bone morphology 0.317274141487455 0.675832688722789 0.984513441878077 0.3 28.2 28 2 abnormal heart right ventricle morphology 0.317274141487455 0.675832688722789 0.984513441878077 0.3 28.2 28 2 abnormal postnatal subventricular zone morphology 0.317274141487455 0.675832688722789 0.984513441878077 0.3 28.2 28 2 abnormal axon extension 0.171499849059676 0.533590837443334 0.984513441878076 0.3 28.2 28 2 epidermal hyperplasia 0.143925801121956 0.466989027306025 0.984513441878076 0.3 28.2 28 2 abnormal long bone epiphyseal plate morphology 0.143925801121956 0.466989027306025 0.984513441878076 0.3 28.2 28 2 abnormal hair cycle 0.252487197559666 0.572526803946828 0.984513441878076 0.3 28.2 28 2 enhanced paired-pulse facilitation 0.252487197559666 0.572526803946828 0.984513441878076 0.3 28.2 28 2 abnormal synaptic transmission 0.252487197559666 0.572526803946828 0.984513441878076 0.3 28.2 28 2 polyuria 0.113392272682943 0.429647034727829 0.980251478926223 0.298701298701299 28.2 28 2 maternal effect 0.133713249770527 0.464395062260441 0.979615365052812 0.298507462686567 28.2 28 2 cleft secondary palate 0.0903046005602943 0.360350439607561 0.977531077042062 0.297872340425532 28.2 28 2 pulmonary hypoplasia 0.189867209798801 0.539606538407382 0.977531077042062 0.297872340425532 28.2 28 2 abnormal nervous system electrophysiology 0.105746985839179 0.403220517467489 0.976699843133013 0.297619047619048 28.2 28 2 decreased circulating chloride level 0.229978248924899 0.539606538407382 0.975643951410706 0.297297297297297 28.2 28 2 increased insulin secretion 0.229978248924899 0.539606538407382 0.975643951410706 0.297297297297297 28.2 28 2 abnormal calcium ion homeostasis 0.229978248924899 0.539606538407382 0.975643951410706 0.297297297297297 28.2 28 2 abnormal mandible morphology 0.17506427075927 0.539606538407382 0.97235895494131 0.296296296296296 28.2 28 2 thin epidermis 0.28395219831915 0.616883050933524 0.97235895494131 0.296296296296296 28.2 28 2 thick interventricular septum 0.28395219831915 0.616883050933524 0.97235895494131 0.296296296296296 28.2 28 2 abnormal gametogenesis 0.21048010280025 0.539606538407382 0.969596571546591 0.295454545454545 28.2 28 2 abnormal long bone morphology 0.161773125080509 0.51164735999716 0.968373877257124 0.295081967213115 28.2 28 2 impaired righting response 0.100585378061738 0.389425880044472 0.967241276231093 0.294736842105263 28.2 28 2 abnormal spatial learning 0.042636214264848 0.228818949263882 0.966393562579707 0.294478527607362 28.2 28 2 abnormal retinal photoreceptor morphology 0.256718123865858 0.58132574703352 0.965209256743212 0.294117647058824 28.2 28 2 overexpanded pulmonary alveoli 0.256718123865858 0.58132574703352 0.965209256743212 0.294117647058824 28.2 28 2 abnormal skin physiology 0.256718123865858 0.58132574703352 0.965209256743212 0.294117647058824 28.2 28 2 distended urinary bladder 0.363374605889367 0.726019543895422 0.965209256743212 0.294117647058824 28.2 28 2 abnormal vagus nerve morphology 0.363374605889367 0.726019543895422 0.965209256743212 0.294117647058824 28.2 28 2 increased incidence of corneal inflammation 0.363374605889367 0.726019543895422 0.965209256743212 0.294117647058824 28.2 28 2 abnormal touch/ nociception 0.363374605889367 0.726019543895422 0.965209256743212 0.294117647058824 28.2 28 2 nephrocalcinosis 0.363374605889367 0.726019543895422 0.965209256743212 0.294117647058824 28.2 28 2 abnormal involuntary movement 0.363374605889367 0.726019543895422 0.965209256743212 0.294117647058824 28.2 28 2 decreased growth hormone level 0.363374605889367 0.726019543895422 0.965209256743212 0.294117647058824 28.2 28 2 common atrium 0.363374605889367 0.726019543895422 0.965209256743212 0.294117647058824 28.2 28 2 abnormal survival 0.363374605889367 0.726019543895422 0.965209256743212 0.294117647058824 28.2 28 2 decreased body fat mass 0.363374605889367 0.726019543895422 0.965209256743212 0.294117647058824 28.2 28 2 female infertility 0.0141826484633783 0.106103272338808 0.962306371760526 0.293233082706767 28.2 28 2 decreased anxiety-related response 0.0765816505124049 0.332455245461793 0.960500918905441 0.292682926829268 28.2 28 2 scaly skin 0.233675532185746 0.539606538407382 0.960500918905441 0.292682926829268 28.2 28 2 decreased monocyte cell number 0.164485148450078 0.51923452635732 0.959269507470946 0.292307692307692 28.2 28 2 curly tail 0.21374988487101 0.539606538407382 0.957165846270352 0.291666666666667 28.2 28 2 abnormal foregut morphology 0.320628053569681 0.681095032668303 0.957165846270352 0.291666666666667 28.2 28 2 curly vibrissae 0.320628053569681 0.681095032668303 0.957165846270352 0.291666666666667 28.2 28 2 abnormal startle reflex 0.320628053569681 0.681095032668303 0.957165846270352 0.291666666666667 28.2 28 2 decreased ovulation rate 0.320628053569681 0.681095032668303 0.957165846270352 0.291666666666667 28.2 28 2 abnormal retinal ganglion layer morphology 0.320628053569681 0.681095032668303 0.957165846270352 0.291666666666667 28.2 28 2 abnormal cellular extravasation 0.320628053569681 0.681095032668303 0.957165846270352 0.291666666666667 28.2 28 2 decreased food intake 0.141068228970156 0.466989027306025 0.955434985788851 0.291139240506329 28.2 28 2 abnormal postnatal growth/weight/body size 0.287285938238168 0.623580952327613 0.952754943752977 0.290322580645161 28.2 28 2 small cranium 0.287285938238168 0.623580952327613 0.952754943752977 0.290322580645161 28.2 28 2 abnormal coat appearance 0.166853673035869 0.521090410140268 0.951220716790412 0.289855072463768 28.2 28 2 abnormal retinal outer nuclear layer morphology 0.259857026249078 0.585944358601657 0.949969110584109 0.289473684210526 28.2 28 2 short tail 0.143026599531545 0.466989027306025 0.948928618677664 0.289156626506024 28.2 28 2 altered response to myocardial infarction 0.236579714984547 0.54439596764483 0.948049981067777 0.288888888888889 28.2 28 2 albuminuria 0.236579714984547 0.54439596764483 0.948049981067777 0.288888888888889 28.2 28 2 abnormal hair growth 0.216420722244947 0.539606538407382 0.946647540267381 0.288461538461538 28.2 28 2 decreased kidney weight 0.216420722244947 0.539606538407382 0.946647540267381 0.288461538461538 28.2 28 2 abnormal female meiosis 0.216420722244947 0.539606538407382 0.946647540267381 0.288461538461538 28.2 28 2 increased percent body fat/body weight 0.216420722244947 0.539606538407382 0.946647540267381 0.288461538461538 28.2 28 2 abnormal ovulation 0.32243610844831 0.681625121533802 0.937631849407692 0.285714285714286 28.2 28 2 straub tail 0.32243610844831 0.681625121533802 0.937631849407692 0.285714285714286 28.2 28 2 abnormal muscle morphology 0.262174767246206 0.589389727541741 0.937631849407692 0.285714285714286 28.2 28 2 abnormal artery morphology 0.289512281653397 0.627318641648802 0.937631849407692 0.285714285714286 28.2 28 2 abnormal intestinal goblet cell morphology 0.289512281653397 0.627318641648802 0.937631849407692 0.285714285714286 28.2 28 2 abnormal midbrain development 0.289512281653397 0.627318641648802 0.937631849407692 0.285714285714286 28.2 28 2 holoprosencephaly 0.289512281653397 0.627318641648802 0.937631849407692 0.285714285714286 28.2 28 2 small ears 0.363843122047281 0.726080839223916 0.937631849407692 0.285714285714286 28.2 28 2 abnormal associative learning 0.363843122047281 0.726080839223916 0.937631849407692 0.285714285714286 28.2 28 2 vascular ring 0.363843122047281 0.726080839223916 0.937631849407692 0.285714285714286 28.2 28 2 increased circulating aspartate transaminase level 0.200771681115168 0.539606538407382 0.937631849407692 0.285714285714286 28.2 28 2 decreased urine osmolality 0.238856364243513 0.549380680587831 0.937631849407692 0.285714285714286 28.2 28 2 abnormal femur morphology 0.202497582296656 0.539606538407382 0.930634596800172 0.283582089552239 28.2 28 2 abnormal sleep pattern 0.263860525656243 0.592911524453391 0.927440198870652 0.282608695652174 28.2 28 2 cardiac fibrosis 0.173679622107795 0.539606538407382 0.926600886473484 0.282352941176471 28.2 28 2 abnormal heart looping 0.290938880285187 0.629587181130406 0.925610928261439 0.282051282051282 28.2 28 2 abnormal lens fiber morphology 0.290938880285187 0.629587181130406 0.925610928261439 0.282051282051282 28.2 28 2 abnormal leukocyte adhesion 0.290938880285187 0.629587181130406 0.925610928261439 0.282051282051282 28.2 28 2 abnormal blood homeostasis 0.140380183017123 0.466989027306025 0.921182167839136 0.280701754385965 28.2 28 2 abnormal feces composition 0.363142671057513 0.726019543895422 0.918879212419538 0.28 28.2 28 2 abnormal axon guidance 0.291771272591816 0.631113948323603 0.915826457561001 0.27906976744186 28.2 28 2 polyphagia 0.265845581173053 0.597102377578302 0.911586520257478 0.277777777777778 28.2 28 2 abnormal heart shape 0.415479278577704 0.743980086736462 0.911586520257478 0.277777777777778 28.2 28 2 underdeveloped hair follicles 0.415479278577704 0.743980086736462 0.911586520257478 0.277777777777778 28.2 28 2 absent spleen 0.415479278577704 0.743980086736462 0.911586520257478 0.277777777777778 28.2 28 2 abnormal phrenic nerve morphology 0.415479278577704 0.743980086736462 0.911586520257478 0.277777777777778 28.2 28 2 thick dermal layer 0.415479278577704 0.743980086736462 0.911586520257478 0.277777777777778 28.2 28 2 abnormal thyroid cartilage morphology 0.415479278577704 0.743980086736462 0.911586520257478 0.277777777777778 28.2 28 2 acidosis 0.415479278577704 0.743980086736462 0.911586520257478 0.277777777777778 28.2 28 2 decreased activity of thyroid 0.415479278577704 0.743980086736462 0.911586520257478 0.277777777777778 28.2 28 2 decreased pulmonary respiratory rate 0.415479278577704 0.743980086736462 0.911586520257478 0.277777777777778 28.2 28 2 abnormal macrophage chemotaxis 0.415479278577704 0.743980086736462 0.911586520257478 0.277777777777778 28.2 28 2 decreased retinal photoreceptor cell number 0.361766234680144 0.72601331889218 0.905299716669496 0.275862068965517 28.2 28 2 abnormal outer ear morphology 0.361766234680144 0.72601331889218 0.905299716669496 0.275862068965517 28.2 28 2 abnormal epidermal layer morphology 0.244256304575022 0.554874481854218 0.903659680950892 0.27536231884058 28.2 28 2 hyperkeratosis 0.244256304575022 0.554874481854218 0.903659680950892 0.27536231884058 28.2 28 2 abnormal food intake 0.244256304575022 0.554874481854218 0.903659680950892 0.27536231884058 28.2 28 2 impaired ovarian folliculogenesis 0.322978558914541 0.681625121533802 0.902470655054903 0.275 28.2 28 2 omphalocele 0.322255461263654 0.681625121533802 0.89501221988916 0.272727272727273 28.2 28 2 abnormal long bone epiphysis morphology 0.410691800824565 0.743980086736462 0.89501221988916 0.272727272727273 28.2 28 2 abnormal tracheal cartilage morphology 0.410691800824565 0.743980086736462 0.89501221988916 0.272727272727273 28.2 28 2 decreased cardiac output 0.410691800824565 0.743980086736462 0.89501221988916 0.272727272727273 28.2 28 2 abnormal circulating lipid level 0.410691800824565 0.743980086736462 0.89501221988916 0.272727272727273 28.2 28 2 decreased susceptibility to viral infection induced morbidity/mortality 0.410691800824565 0.743980086736462 0.89501221988916 0.272727272727273 28.2 28 2 thick epidermis 0.266360282109189 0.597988449229789 0.890750256937307 0.271428571428571 28.2 28 2 increased susceptibility to pharmacologically induced seizures 0.225637939333411 0.539606538407382 0.888796857251041 0.270833333333333 28.2 28 2 abnormal hair shaft morphology 0.321272905758862 0.681625121533802 0.888796857251041 0.270833333333333 28.2 28 2 abnormal vocalization 0.357932517493641 0.72239930001252 0.886949046737006 0.27027027027027 28.2 28 2 abnormal humerus morphology 0.357932517493641 0.72239930001252 0.886949046737006 0.27027027027027 28.2 28 2 thick skin 0.406019937511046 0.743980086736462 0.883537704249556 0.269230769230769 28.2 28 2 abnormal ocular fundus morphology 0.406019937511046 0.743980086736462 0.883537704249556 0.269230769230769 28.2 28 2 short ulna 0.355723002048433 0.718522913191617 0.88045917566332 0.268292682926829 28.2 28 2 lethality at weaning, incomplete penetrance 0.355723002048433 0.718522913191617 0.88045917566332 0.268292682926829 28.2 28 2 abnormal eye physiology 0.317335710724912 0.675832688722789 0.875123059447179 0.266666666666667 28.2 28 2 abnormal heart tube morphology 0.401504066360317 0.743980086736462 0.875123059447179 0.266666666666667 28.2 28 2 delayed eyelid opening 0.401504066360317 0.743980086736462 0.875123059447179 0.266666666666667 28.2 28 2 emphysema 0.401504066360317 0.743980086736462 0.875123059447179 0.266666666666667 28.2 28 2 liver hemorrhage 0.401504066360317 0.743980086736462 0.875123059447179 0.266666666666667 28.2 28 2 impaired synaptic plasticity 0.397152039385153 0.743980086736462 0.868688331068891 0.264705882352941 28.2 28 2 decreased pancreatic beta cell number 0.397152039385153 0.743980086736462 0.868688331068891 0.264705882352941 28.2 28 2 abnormal heart left ventricle morphology 0.312589183174234 0.667724854569262 0.866007194244604 0.263888888888889 28.2 28 2 increased susceptibility to bacterial infection induced morbidity/mortality 0.312589183174234 0.667724854569262 0.866007194244604 0.263888888888889 28.2 28 2 decreased grooming behavior 0.466826558470943 0.80837526223214 0.86360828234919 0.263157894736842 28.2 28 2 unresponsive to tactile stimuli 0.466826558470943 0.80837526223214 0.86360828234919 0.263157894736842 28.2 28 2 decreased germ cell number 0.466826558470943 0.80837526223214 0.86360828234919 0.263157894736842 28.2 28 2 abnormal neural crest cell migration 0.466826558470943 0.80837526223214 0.86360828234919 0.263157894736842 28.2 28 2 abnormal response to novelty 0.466826558470943 0.80837526223214 0.86360828234919 0.263157894736842 28.2 28 2 abnormal cochlear inner hair cell morphology 0.466826558470943 0.80837526223214 0.86360828234919 0.263157894736842 28.2 28 2 abnormal blastocyst morphology 0.466826558470943 0.80837526223214 0.86360828234919 0.263157894736842 28.2 28 2 increased liver cholesterol level 0.466826558470943 0.80837526223214 0.86360828234919 0.263157894736842 28.2 28 2 abnormal vibrissa morphology 0.388917536978256 0.743980086736462 0.859495861957051 0.261904761904762 28.2 28 2 fragile skeleton 0.457161355278423 0.794126306742373 0.856098645111371 0.260869565217391 28.2 28 2 abnormal sacral vertebrae morphology 0.457161355278423 0.794126306742373 0.856098645111371 0.260869565217391 28.2 28 2 abnormal digestive system physiology 0.381244983574705 0.743980086736462 0.853244982961 0.26 28.2 28 2 abnormal circulating protein level 0.381244983574705 0.743980086736462 0.853244982961 0.26 28.2 28 2 abnormal neuronal precursor proliferation 0.377594745778058 0.743980086736462 0.850814085573646 0.259259259259259 28.2 28 2 abnormal osteoblast physiology 0.377594745778058 0.743980086736462 0.850814085573646 0.259259259259259 28.2 28 2 cryptorchism 0.448743646228209 0.780048791050084 0.850814085573646 0.259259259259259 28.2 28 2 decreased susceptibility to pharmacologically induced seizures 0.448743646228209 0.780048791050084 0.850814085573646 0.259259259259259 28.2 28 2 abnormal retinal photoreceptor layer morphology 0.441232110924542 0.768333829838851 0.84689328333598 0.258064516129032 28.2 28 2 decreased neuronal precursor cell number 0.441232110924542 0.768333829838851 0.84689328333598 0.258064516129032 28.2 28 2 impaired fertilization 0.364039149405478 0.72618074109553 0.843868664466923 0.257142857142857 28.2 28 2 abnormal dermal layer morphology 0.434411955523068 0.75698755822321 0.843868664466923 0.257142857142857 28.2 28 2 impaired behavioral response to xenobiotic 0.434411955523068 0.75698755822321 0.843868664466923 0.257142857142857 28.2 28 2 abnormal excitatory postsynaptic potential 0.354787247202339 0.717215178720698 0.84043830404226 0.25609756097561 28.2 28 2 abnormal innervation 0.416855153801834 0.743980086736462 0.837883780321767 0.25531914893617 28.2 28 2 increased circulating calcium level 0.406842645475141 0.743980086736462 0.835344738563216 0.254545454545455 28.2 28 2 decreased inflammatory response 0.401626964469757 0.743980086736462 0.820427868231731 0.25 28.2 28 2 abnormal stria vascularis morphology 0.49084615882151 0.839123202196401 0.820427868231731 0.25 28.2 28 2 enhanced coordination 0.49084615882151 0.839123202196401 0.820427868231731 0.25 28.2 28 2 decreased circulating progesterone level 0.49084615882151 0.839123202196401 0.820427868231731 0.25 28.2 28 2 short femur 0.397475250543419 0.743980086736462 0.82042786823173 0.25 28.2 28 2 abnormal skin condition 0.442252566533448 0.769841329077643 0.82042786823173 0.25 28.2 28 2 abnormal cardiovascular system morphology 0.448715903149491 0.780048791050084 0.82042786823173 0.25 28.2 28 2 abnormal phalanx morphology 0.448715903149491 0.780048791050084 0.82042786823173 0.25 28.2 28 2 increased susceptibility to weight loss 0.463192474136174 0.804322010061943 0.82042786823173 0.25 28.2 28 2 abnormal adrenal gland morphology 0.502672455848005 0.85495181131099 0.82042786823173 0.25 28.2 28 2 abnormal sensory capabilities/reflexes/nociception 0.502672455848005 0.85495181131099 0.82042786823173 0.25 28.2 28 2 abnormal primitive streak formation 0.502672455848005 0.85495181131099 0.82042786823173 0.25 28.2 28 2 increased urine glucose level 0.516677364132105 0.863349436911827 0.82042786823173 0.25 28.2 28 2 brain inflammation 0.516677364132105 0.863349436911827 0.82042786823173 0.25 28.2 28 2 anencephaly 0.516677364132105 0.863349436911827 0.82042786823173 0.25 28.2 28 2 abnormal dopamine level 0.516677364132105 0.863349436911827 0.82042786823173 0.25 28.2 28 2 abnormal hair texture 0.516677364132105 0.863349436911827 0.82042786823173 0.25 28.2 28 2 kidney atrophy 0.516677364132105 0.863349436911827 0.82042786823173 0.25 28.2 28 2 abnormal systemic arterial blood pressure 0.471432513115647 0.815783218347945 0.82042786823173 0.25 28.2 28 2 abnormal uterus morphology 0.471432513115647 0.815783218347945 0.82042786823173 0.25 28.2 28 2 abnormal vertebral body morphology 0.480563867472568 0.826124824006919 0.82042786823173 0.25 28.2 28 2 abnormal crypts of Lieberkuhn morphology 0.480563867472568 0.826124824006919 0.82042786823173 0.25 28.2 28 2 abnormal eye electrophysiology 0.388033288269237 0.743980086736462 0.81364747262651 0.247933884297521 28.2 28 2 abnormal epidermis stratum corneum morphology 0.480396379423032 0.826124824006919 0.80368444234945 0.244897959183673 28.2 28 2 abnormal cartilage development 0.488745557167476 0.839123202196401 0.802196137826581 0.244444444444444 28.2 28 2 diarrhea 0.51915123118688 0.863349436911827 0.795566417679254 0.242424242424242 28.2 28 2 decreased sensitivity to xenobiotic induced morbidity/mortality 0.51915123118688 0.863349436911827 0.795566417679254 0.242424242424242 28.2 28 2 abnormal parietal bone morphology 0.53191704377558 0.863349436911827 0.792137252085809 0.241379310344828 28.2 28 2 abnormal cochlea morphology 0.502831959778081 0.85495181131099 0.790041650889815 0.240740740740741 28.2 28 2 mandible hypoplasia 0.546734493150265 0.863349436911827 0.787610753502461 0.24 28.2 28 2 diaphragmatic hernia 0.546734493150265 0.863349436911827 0.787610753502461 0.24 28.2 28 2 abnormal stomach mucosa morphology 0.546734493150265 0.863349436911827 0.787610753502461 0.24 28.2 28 2 hypoalgesia 0.564438064783612 0.879173253693949 0.78135987450641 0.238095238095238 28.2 28 2 increased acute inflammation 0.564438064783612 0.879173253693949 0.78135987450641 0.238095238095238 28.2 28 2 increased keratinocyte proliferation 0.564438064783612 0.879173253693949 0.78135987450641 0.238095238095238 28.2 28 2 decreased vocalization 0.564438064783612 0.879173253693949 0.78135987450641 0.238095238095238 28.2 28 2 abnormal digit morphology 0.525190781508809 0.863349436911827 0.774848542218856 0.236111111111111 28.2 28 2 abnormal response to novel object 0.542474709107341 0.863349436911827 0.77216740539457 0.235294117647059 28.2 28 2 abnormal vision 0.55668944404895 0.868382338760796 0.77216740539457 0.235294117647059 28.2 28 2 increased susceptibility to viral infection induced morbidity/mortality 0.55668944404895 0.868382338760796 0.77216740539457 0.235294117647059 28.2 28 2 increased systemic arterial blood pressure 0.553274087781938 0.868382338760796 0.76806013196162 0.234042553191489 28.2 28 2 abnormal pain threshold 0.571607949945443 0.890062457270291 0.765732677016282 0.233333333333333 28.2 28 2 small lens 0.578225819859609 0.899522655972969 0.757318032213905 0.230769230769231 28.2 28 2 acanthosis 0.578225819859609 0.899522655972969 0.757318032213905 0.230769230769231 28.2 28 2 increased vascular permeability 0.578225819859609 0.899522655972969 0.757318032213905 0.230769230769231 28.2 28 2 no spontaneous movement 0.588948859842031 0.904123667768894 0.757318032213905 0.230769230769231 28.2 28 2 oligodactyly 0.584358953483477 0.904123667768894 0.75205887921242 0.229166666666667 28.2 28 2 abnormal circulating amino acid level 0.590082790477805 0.904123667768894 0.748460511369298 0.228070175438596 28.2 28 2 abnormal amino acid level 0.597306050053057 0.914056474627486 0.7458435165743 0.227272727272727 28.2 28 2 abnormal facial nerve morphology 0.609657554183333 0.930667791366088 0.7458435165743 0.227272727272727 28.2 28 2 increased body size 0.609657554183333 0.930667791366088 0.7458435165743 0.227272727272727 28.2 28 2 abnormal female reproductive system physiology 0.609657554183333 0.930667791366088 0.7458435165743 0.227272727272727 28.2 28 2 abnormal basement membrane morphology 0.609657554183333 0.930667791366088 0.7458435165743 0.227272727272727 28.2 28 2 embryonic lethality before implantation, incomplete penetrance 0.609657554183333 0.930667791366088 0.7458435165743 0.227272727272727 28.2 28 2 abnormal nose morphology 0.609634236326539 0.930667791366088 0.741031622918982 0.225806451612903 28.2 28 2 abnormal intestine physiology 0.609634236326539 0.930667791366088 0.741031622918982 0.225806451612903 28.2 28 2 abnormal mitochondrial ATP synthesis coupled electron transport 0.609634236326539 0.930667791366088 0.741031622918982 0.225806451612903 28.2 28 2 abnormal enzyme/coenzyme level 0.617666578602863 0.939434799311906 0.735556019793965 0.224137931034483 28.2 28 2 rectal prolapse 0.629007492303123 0.950320539947227 0.729269216205983 0.222222222222222 28.2 28 2 wrinkled skin 0.629007492303123 0.950320539947227 0.729269216205983 0.222222222222222 28.2 28 2 abnormal reflex 0.627630467563563 0.950320539947227 0.729269216205983 0.222222222222222 28.2 28 2 abnormal inhibitory postsynaptic currents 0.645844503168293 0.950320539947227 0.723906942557409 0.220588235294118 28.2 28 2 abnormal colon morphology 0.644322759783226 0.950320539947227 0.723088968611017 0.220338983050847 28.2 28 2 abnormal hindlimb morphology 0.643433034076277 0.950320539947227 0.721976524043923 0.22 28.2 28 2 decreased oocyte number 0.643433034076277 0.950320539947227 0.721976524043923 0.22 28.2 28 2 increased circulating follicle stimulating hormone level 0.645773939605652 0.950320539947227 0.717874384702764 0.21875 28.2 28 2 increased dopamine level 0.645773939605652 0.950320539947227 0.717874384702764 0.21875 28.2 28 2 abnormal long term potentiation 0.645773939605652 0.950320539947227 0.717874384702764 0.21875 28.2 28 2 abnormal diaphragm morphology 0.645773939605652 0.950320539947227 0.717874384702764 0.21875 28.2 28 2 abnormal forelimb morphology 0.658039189724951 0.950320539947227 0.713415537592809 0.217391304347826 28.2 28 2 abnormal retinal cone cell morphology 0.652017609434696 0.950320539947227 0.713415537592809 0.217391304347826 28.2 28 2 blistering 0.652017609434696 0.950320539947227 0.713415537592809 0.217391304347826 28.2 28 2 failure of embryo implantation 0.652017609434696 0.950320539947227 0.713415537592809 0.217391304347826 28.2 28 2 abnormal nasal cavity morphology 0.652017609434696 0.950320539947227 0.713415537592809 0.217391304347826 28.2 28 2 myoclonus 0.666687855979927 0.961383212608735 0.703223887055769 0.214285714285714 28.2 28 2 abnormal jaw morphology 0.666687855979927 0.961383212608735 0.703223887055769 0.214285714285714 28.2 28 2 abnormal retinal inner nuclear layer morphology 0.666687855979927 0.961383212608735 0.703223887055769 0.214285714285714 28.2 28 2 abnormal cartilage morphology 0.674085697797473 0.969802298016896 0.703223887055769 0.214285714285714 28.2 28 2 absent vibrissae 0.679864668795321 0.976710282348452 0.696120615469347 0.212121212121212 28.2 28 2 decreased systemic arterial blood pressure 0.679864668795321 0.976710282348452 0.696120615469347 0.212121212121212 28.2 28 2 abnormal middle ear ossicle morphology 0.679864668795321 0.976710282348452 0.696120615469347 0.212121212121212 28.2 28 2 decreased threshold for auditory brainstem response 0.691872884921233 0.99252237672524 0.690886625879352 0.210526315789474 28.2 28 2 apnea 0.69131896564172 0.992013802730764 0.683689890193109 0.208333333333333 28.2 28 2 hypopigmentation 0.69131896564172 0.992013802730764 0.683689890193109 0.208333333333333 28.2 28 2 focal hair loss 0.70184545916367 1 0.678974787502122 0.206896551724138 28.2 28 2 decreased susceptibility to injury 0.748278169479299 1 0.675646479720249 0.205882352941176 28.2 28 2 hypertension 0.730091692096577 1 0.67125916491687 0.204545454545455 28.2 28 2 abnormal response to new environment 0.734404836468226 1 0.656342294585384 0.2 28.2 28 2 abnormal epidermis stratum granulosum morphology 0.769009062495721 1 0.638110564180235 0.194444444444444 28.2 28 2 abnormal body temperature homeostasis 0.764349780502231 1 0.635169962501985 0.193548387096774 28.2 28 2 small seminal vesicle 0.760445137079477 1 0.631098360178254 0.192307692307692 28.2 28 2 abnormal intestinal mucosa morphology 0.81919525791441 1 0.610550971707334 0.186046511627907 28.2 28 2 abnormal autopod morphology 0.857041946238656 1 0.583415372964786 0.177777777777778 28.2 28 2 increased retinal apoptosis 0.841224101969675 1 0.565812322918435 0.172413793103448 28.2 28 2 abnormal ion homeostasis 0.000211120718939349 0.00783825057256167 3.35073627844712 0.777777777777778 29.1 29 1 abnormal erythrocyte cell number 0.000879406212692935 0.0227609538950862 3.23106712564544 0.75 29.1 29 1 pulmonary interstitial fibrosis 0.000879406212692935 0.0227609538950862 3.23106712564544 0.75 29.1 29 1 failure of atrioventricular cushion closure 0.00354135079531273 0.0593206067565011 3.07720678632899 0.714285714285714 29.1 29 1 increased retinal ganglion cell number 0.00354135079531273 0.0593206067565011 3.07720678632899 0.714285714285714 29.1 29 1 uremia 0.00354135079531273 0.0593206067565011 3.07720678632899 0.714285714285714 29.1 29 1 abnormal pillar cell morphology 0.000588564582505617 0.0167320502740882 3.01566265060241 0.7 29.1 29 1 abnormal spinal cord dorsal column morphology 0.000588564582505617 0.0167320502740882 3.01566265060241 0.7 29.1 29 1 abnormal NMDA-mediated synaptic currents 0.00221597720020011 0.0428968349065975 2.87205966724039 0.666666666666667 29.1 29 1 biliary cyst 0.00221597720020011 0.0428968349065975 2.87205966724039 0.666666666666667 29.1 29 1 pancreas cysts 0.00221597720020011 0.0428968349065975 2.87205966724039 0.666666666666667 29.1 29 1 abnormal artery development 0.00221597720020011 0.0428968349065975 2.87205966724039 0.666666666666667 29.1 29 1 abnormal hippocampus granule cell morphology 0.00221597720020011 0.0428968349065975 2.87205966724039 0.666666666666667 29.1 29 1 pulmonary alveolar hemorrhage 0.000236567452555613 0.00852842809032009 2.76948610769609 0.642857142857143 29.1 29 1 common atrioventricular valve 0.00135454836235903 0.0306312641033461 2.74151150054765 0.636363636363636 29.1 29 1 poor grooming 0.00797792509967905 0.098486792483631 2.69255593803787 0.625 29.1 29 1 decreased corneal stroma thickness 0.00797792509967905 0.098486792483631 2.69255593803787 0.625 29.1 29 1 abnormal kidney epithelium morphology 0.00797792509967905 0.098486792483631 2.69255593803787 0.625 29.1 29 1 abnormal ilium morphology 0.00797792509967905 0.098486792483631 2.69255593803787 0.625 29.1 29 1 abnormal frontonasal prominence morphology 0.00797792509967905 0.098486792483631 2.69255593803787 0.625 29.1 29 1 increased caudal vertebrae number 0.00797792509967905 0.098486792483631 2.69255593803787 0.625 29.1 29 1 decreased alveolar lamellar body number 0.00797792509967905 0.098486792483631 2.69255593803787 0.625 29.1 29 1 increased brain apoptosis 0.00797792509967905 0.098486792483631 2.69255593803787 0.625 29.1 29 1 increased synaptic depression 0.000818907408016774 0.0215558960575844 2.65113200052959 0.615384615384615 29.1 29 1 abnormal coping response 0.000818907408016774 0.0215558960575844 2.65113200052959 0.615384615384615 29.1 29 1 decreased paired-pulse facilitation 5.47058950639584e-05 0.0025435684854504 2.58485370051635 0.6 29.1 29 1 impaired social transmission of food preference 0.00465709612674186 0.0721777359206876 2.58485370051635 0.6 29.1 29 1 impaired basement membrane formation 0.00465709612674186 0.0721777359206876 2.58485370051635 0.6 29.1 29 1 peritoneal inflammation 0.00465709612674186 0.0721777359206876 2.58485370051635 0.6 29.1 29 1 abnormal plasma membrane morphology 0.00465709612674186 0.0721777359206876 2.58485370051635 0.6 29.1 29 1 abnormal cerebellar granule cell migration 0.00465709612674186 0.0721777359206876 2.58485370051635 0.6 29.1 29 1 thin ventricle myocardium compact layer 0.00465709612674186 0.0721777359206876 2.58485370051635 0.6 29.1 29 1 increased compact bone area 0.00465709612674186 0.0721777359206876 2.58485370051635 0.6 29.1 29 1 absent long term depression 2.34046735410091e-06 0.000179135770563877 2.52543177636655 0.586206896551724 29.1 29 1 abnormal rectum morphology 0.0027224865703113 0.0501680049428837 2.51305220883534 0.583333333333333 29.1 29 1 decreased synaptic depression 0.0027224865703113 0.0501680049428837 2.51305220883534 0.583333333333333 29.1 29 1 dilated bile duct 0.0027224865703113 0.0501680049428837 2.51305220883534 0.583333333333333 29.1 29 1 decreased red blood cell distribution width 0.0027224865703113 0.0501680049428837 2.51305220883534 0.583333333333333 29.1 29 1 decreased liver glycogen level 0.00017670074789693 0.00686786109990022 2.4941570794456 0.578947368421053 29.1 29 1 abnormal embryonic/fetal subventricular zone morphology 0.000105720993975549 0.00453415469852033 2.46176542906319 0.571428571428571 29.1 29 1 abnormal adrenal gland secretion 0.00159536068196499 0.0348110499683149 2.46176542906319 0.571428571428571 29.1 29 1 abnormal synaptic transmission 4.45047173701577e-06 0.000295214625222046 2.44125071715433 0.566666666666667 29.1 29 1 abnormal long term potentiation 2.68614607562107e-06 0.000199456369047983 2.42330034423408 0.5625 29.1 29 1 blepharitis 0.00093726369606841 0.023227383534434 2.42330034423408 0.5625 29.1 29 1 abnormal head movements 0.0151803599740277 0.149253539270332 2.39338305603366 0.555555555555556 29.1 29 1 decreased level of surface class I molecules 0.0151803599740277 0.149253539270332 2.39338305603366 0.555555555555556 29.1 29 1 premature neuronal precursor differentiation 0.0151803599740277 0.149253539270332 2.39338305603366 0.555555555555556 29.1 29 1 small scapula 0.0151803599740277 0.149253539270332 2.39338305603366 0.555555555555556 29.1 29 1 positive geotaxis 0.0151803599740277 0.149253539270332 2.39338305603366 0.555555555555556 29.1 29 1 eye opacity 0.0151803599740277 0.149253539270332 2.39338305603366 0.555555555555556 29.1 29 1 decreased effector memory CD4-positive, alpha-beta T cell number 0.0151803599740277 0.149253539270332 2.39338305603366 0.555555555555556 29.1 29 1 reduced AMPA-mediated synaptic currents 0.0151803599740277 0.149253539270332 2.39338305603366 0.555555555555556 29.1 29 1 abnormal fear/anxiety-related behavior 0.00862015344400125 0.101144489112986 2.34986700046941 0.545454545454545 29.1 29 1 fatigue 0.00862015344400125 0.101144489112986 2.34986700046941 0.545454545454545 29.1 29 1 loss of cortex neurons 0.00862015344400125 0.101144489112986 2.34986700046941 0.545454545454545 29.1 29 1 abnormal platelet aggregation 0.00862015344400125 0.101144489112986 2.34986700046941 0.545454545454545 29.1 29 1 abnormal superovulation 0.00862015344400125 0.101144489112986 2.34986700046941 0.545454545454545 29.1 29 1 abnormal brain wave pattern 1.71131425904158e-08 2.43251098249481e-06 2.31974050046339 0.538461538461538 29.1 29 1 dystrophic cardiac calcinosis 0.00494332892632158 0.073412123607313 2.31974050046339 0.538461538461538 29.1 29 1 axonal dystrophy 0.00494332892632158 0.073412123607313 2.31974050046339 0.538461538461538 29.1 29 1 abnormal exocrine pancreas morphology 0.00494332892632158 0.073412123607313 2.31974050046339 0.538461538461538 29.1 29 1 hyperalgesia 0.00494332892632158 0.073412123607313 2.31974050046339 0.538461538461538 29.1 29 1 enhanced long term potentiation 6.22931743358526e-09 9.99704975228602e-07 2.30790508974674 0.535714285714286 29.1 29 1 absent corpus callosum 4.02744237689102e-05 0.00202389149747806 2.30790508974674 0.535714285714286 29.1 29 1 enhanced paired-pulse facilitation 2.39688988354418e-05 0.00125966613713968 2.29764773379231 0.533333333333333 29.1 29 1 abnormal rostral migratory stream morphology 0.00285595810290114 0.0511093221652272 2.29764773379231 0.533333333333333 29.1 29 1 abnormal trophectoderm morphology 0.00285595810290114 0.0511093221652272 2.29764773379231 0.533333333333333 29.1 29 1 abnormal secondary palate development 0.00285595810290114 0.0511093221652272 2.29764773379231 0.533333333333333 29.1 29 1 impaired synaptic plasticity 8.51898016997931e-06 0.000504546742210084 2.28075326516149 0.529411764705882 29.1 29 1 abnormal cranial suture morphology 0.00165963165636175 0.0354363411605138 2.28075326516149 0.529411764705882 29.1 29 1 common atrium 0.00165963165636175 0.0354363411605138 2.28075326516149 0.529411764705882 29.1 29 1 abnormal contextual conditioning behavior 1.79034872375369e-08 2.47416247240961e-06 2.27153810045376 0.527272727272727 29.1 29 1 kyphoscoliosis 0.000968958846389349 0.0237466515309705 2.26741552676873 0.526315789473684 29.1 29 1 abnormal excitatory postsynaptic potential 8.82972466632985e-12 2.19639401074955e-09 2.25912010410982 0.524390243902439 29.1 29 1 decreased vocalization 0.000567898599481746 0.0164261368164051 2.25661830997459 0.523809523809524 29.1 29 1 impaired limb coordination 5.06678529758569e-08 5.60161263455307e-06 2.23382418563141 0.518518518518518 29.1 29 1 abnormal excitatory postsynaptic currents 1.14508851216525e-10 2.27872613920884e-08 2.20927666710799 0.512820512820513 29.1 29 1 abnormal CNS synaptic transmission 1.20649873445707e-12 3.75145700245246e-10 2.17580277821242 0.505050505050505 29.1 29 1 abnormal channel response 0.000943101803810184 0.023227383534434 2.15404475043029 0.5 29.1 29 1 abnormal cerebral cortex pyramidal cell morphology 0.000943101803810184 0.023227383534434 2.15404475043029 0.5 29.1 29 1 impaired muscle relaxation 0.00477465250973387 0.0726418845135352 2.15404475043029 0.5 29.1 29 1 dilated respiratory conducting tubes 0.00477465250973387 0.0726418845135352 2.15404475043029 0.5 29.1 29 1 fused cornea and lens 0.0257036238213136 0.214556255890999 2.15404475043029 0.5 29.1 29 1 abnormal PNS synaptic transmission 0.0257036238213136 0.214556255890999 2.15404475043029 0.5 29.1 29 1 acrania 0.0257036238213136 0.214556255890999 2.15404475043029 0.5 29.1 29 1 absent seminal vesicle 0.0257036238213136 0.214556255890999 2.15404475043029 0.5 29.1 29 1 increased atrioventricular cushion size 0.0257036238213136 0.214556255890999 2.15404475043029 0.5 29.1 29 1 tachypnea 0.0257036238213136 0.214556255890999 2.15404475043029 0.5 29.1 29 1 impaired behavioral response to morphine 0.0257036238213136 0.214556255890999 2.15404475043029 0.5 29.1 29 1 decreased trabecular bone connectivity density 0.0257036238213136 0.214556255890999 2.15404475043029 0.5 29.1 29 1 reduced long term depression 2.3812649731757e-05 0.00125966613713968 2.15404475043029 0.5 29.1 29 1 myoclonus 0.000192418893140968 0.00736372302597166 2.15404475043029 0.5 29.1 29 1 abnormal radius morphology 0.00276728241290911 0.0501680049428837 2.15404475043029 0.5 29.1 29 1 abnormal eye anterior chamber morphology 0.00276728241290911 0.0501680049428837 2.15404475043029 0.5 29.1 29 1 increased effector memory CD4-positive, alpha-beta T cell number 0.00276728241290911 0.0501680049428837 2.15404475043029 0.5 29.1 29 1 abnormal aerobic respiration 0.00276728241290911 0.0501680049428837 2.15404475043029 0.5 29.1 29 1 increased adipocyte glucose uptake 0.00276728241290911 0.0501680049428837 2.15404475043029 0.5 29.1 29 1 translucent skin 0.00829129717067816 0.0991567390002977 2.15404475043029 0.5 29.1 29 1 intestinal obstruction 0.00829129717067816 0.0991567390002977 2.15404475043029 0.5 29.1 29 1 amyloid beta deposits 0.00829129717067816 0.0991567390002977 2.15404475043029 0.5 29.1 29 1 abnormal vascular endothelial cell migration 0.00829129717067816 0.0991567390002977 2.15404475043029 0.5 29.1 29 1 premature hair loss 0.00829129717067816 0.0991567390002977 2.15404475043029 0.5 29.1 29 1 decreased cornea thickness 0.00829129717067816 0.0991567390002977 2.15404475043029 0.5 29.1 29 1 increased lung compliance 0.00829129717067816 0.0991567390002977 2.15404475043029 0.5 29.1 29 1 abnormal supraoccipital bone morphology 0.0145178203176912 0.148004418197774 2.15404475043029 0.5 29.1 29 1 abnormal thymus involution 0.0145178203176912 0.148004418197774 2.15404475043029 0.5 29.1 29 1 abnormal tracheal ciliated epithelium morphology 0.0145178203176912 0.148004418197774 2.15404475043029 0.5 29.1 29 1 abnormal corticospinal tract morphology 0.0145178203176912 0.148004418197774 2.15404475043029 0.5 29.1 29 1 abnormal AMPA-mediated synaptic currents 0.0145178203176912 0.148004418197774 2.15404475043029 0.5 29.1 29 1 abnormal axon guidance 8.10612469283047e-06 0.0004858791608052 2.1039506864668 0.488372093023256 29.1 29 1 abnormal inhibitory postsynaptic currents 2.7883894329185e-08 3.55698395609476e-06 2.0906904930647 0.485294117647059 29.1 29 1 increased cardiomyocyte apoptosis 0.000108101918250969 0.00459664139571429 2.08877066708392 0.484848484848485 29.1 29 1 rectal prolapse 0.000520645896327678 0.0155102594864084 2.07426531522917 0.481481481481481 29.1 29 1 decreased susceptibility to pharmacologically induced seizures 0.000520645896327678 0.0155102594864084 2.07426531522917 0.481481481481481 29.1 29 1 increased liver glycogen level 0.000882987759146058 0.0227609538950862 2.06788296041308 0.48 29.1 29 1 abnormal Wolffian duct morphology 0.0015015239641783 0.0333485791151207 2.06039063084637 0.478260869565217 29.1 29 1 decreased effector memory CD8-positive, alpha-beta T cell number 0.0015015239641783 0.0333485791151207 2.06039063084637 0.478260869565217 29.1 29 1 trunk curl 0.00256139714772607 0.0480866068299517 2.05147119088599 0.476190476190476 29.1 29 1 abnormal long term depression 0.0043857736227769 0.0705603263460902 2.04067397409186 0.473684210526316 29.1 29 1 decreased fertilization frequency 0.0043857736227769 0.0705603263460902 2.04067397409186 0.473684210526316 29.1 29 1 embryonic lethality between implantation and somite formation, incomplete penetrance 0.0043857736227769 0.0705603263460902 2.04067397409186 0.473684210526316 29.1 29 1 seizures 4.14407958728282e-12 1.158988424434e-09 2.04067397409186 0.473684210526316 29.1 29 1 abnormal cued conditioning behavior 4.25053606113184e-06 0.000285762390596364 2.0273362356991 0.470588235294118 29.1 29 1 abnormal vision 0.000168591310994482 0.00660426592281533 2.0273362356991 0.470588235294118 29.1 29 1 abnormal adipose tissue morphology 0.00754355993495355 0.0967247697845204 2.0273362356991 0.470588235294118 29.1 29 1 abnormal touch/ nociception 0.00754355993495355 0.0967247697845204 2.0273362356991 0.470588235294118 29.1 29 1 absence seizures 0.00754355993495355 0.0967247697845204 2.0273362356991 0.470588235294118 29.1 29 1 enhanced behavioral response to cocaine 0.00754355993495355 0.0967247697845204 2.0273362356991 0.470588235294118 29.1 29 1 abnormal survival 0.00754355993495355 0.0967247697845204 2.0273362356991 0.470588235294118 29.1 29 1 abnormal brain vasculature morphology 0.000477348218228477 0.0146593048499177 2.01044176706827 0.466666666666667 29.1 29 1 audiogenic seizures 0.0130472188549831 0.141108508268567 2.01044176706827 0.466666666666667 29.1 29 1 abnormal seizure response to electrical stimulation 0.0130472188549831 0.141108508268567 2.01044176706827 0.466666666666667 29.1 29 1 placental labyrinth hypoplasia 0.0130472188549831 0.141108508268567 2.01044176706827 0.466666666666667 29.1 29 1 abnormal neuron morphology 3.51226260772936e-10 6.47166906424207e-08 2.00173855595542 0.464646464646465 29.1 29 1 decreased exploration in new environment 7.72640698021246e-09 1.20121483520491e-06 2.00018441111384 0.464285714285714 29.1 29 1 short premaxilla 0.0227245272245795 0.196293464763553 1.98834900039719 0.461538461538462 29.1 29 1 absent myocardial trabeculae 0.0227245272245795 0.196293464763553 1.98834900039719 0.461538461538462 29.1 29 1 small trigeminal ganglion 0.0227245272245795 0.196293464763553 1.98834900039719 0.461538461538462 29.1 29 1 excessive scratching 0.0227245272245795 0.196293464763553 1.98834900039719 0.461538461538462 29.1 29 1 abnormal afterhyperpolarization 0.0227245272245795 0.196293464763553 1.98834900039719 0.461538461538462 29.1 29 1 abnormal retinal inner plexiform layer morphology 0.0227245272245795 0.196293464763553 1.98834900039719 0.461538461538462 29.1 29 1 absent hypoglossal nerve 0.0227245272245795 0.196293464763553 1.98834900039719 0.461538461538462 29.1 29 1 short stride length 1.07799362104177e-05 0.000630943325256802 1.98172117039587 0.46 29.1 29 1 abnormal sensory capabilities/reflexes/nociception 0.00230356913719633 0.0442480944307016 1.97454102122777 0.458333333333333 29.1 29 1 impaired behavioral response to xenobiotic 0.000256473828435556 0.00886081455879787 1.96941234325055 0.457142857142857 29.1 29 1 lethality, incomplete penetrance 4.95842107738755e-05 0.00237193700576952 1.95822250039118 0.454545454545455 29.1 29 1 increased myocardial infarction size 0.00390997660098931 0.0646250285379462 1.95822250039118 0.454545454545455 29.1 29 1 premature suture closure 0.0399398491357406 0.264229720013709 1.95822250039118 0.454545454545455 29.1 29 1 abnormal sphenoid bone morphology 0.0399398491357406 0.264229720013709 1.95822250039118 0.454545454545455 29.1 29 1 abnormal thrombopoiesis 0.0399398491357406 0.264229720013709 1.95822250039118 0.454545454545455 29.1 29 1 abnormal stomach epithelium morphology 0.0399398491357406 0.264229720013709 1.95822250039118 0.454545454545455 29.1 29 1 social withdrawal 0.0399398491357406 0.264229720013709 1.95822250039118 0.454545454545455 29.1 29 1 abnormal vestibular ganglion morphology 0.0399398491357406 0.264229720013709 1.95822250039118 0.454545454545455 29.1 29 1 abnormal radial glial cell morphology 0.0399398491357406 0.264229720013709 1.95822250039118 0.454545454545455 29.1 29 1 abnormal dorsal-ventral polarity of the somites 0.0399398491357406 0.264229720013709 1.95822250039118 0.454545454545455 29.1 29 1 increased glycogen level 0.0399398491357406 0.264229720013709 1.95822250039118 0.454545454545455 29.1 29 1 increased circulating triiodothyronine level 0.0399398491357406 0.264229720013709 1.95822250039118 0.454545454545455 29.1 29 1 enhanced behavioral response to addictive substance 0.0399398491357406 0.264229720013709 1.95822250039118 0.454545454545455 29.1 29 1 decreased palatine bone horizontal plate size 0.0399398491357406 0.264229720013709 1.95822250039118 0.454545454545455 29.1 29 1 aorta dilation 0.0399398491357406 0.264229720013709 1.95822250039118 0.454545454545455 29.1 29 1 chylous ascites 0.0399398491357406 0.264229720013709 1.95822250039118 0.454545454545455 29.1 29 1 thin hypoglossal nerve 0.0399398491357406 0.264229720013709 1.95822250039118 0.454545454545455 29.1 29 1 abnormal pancreas morphology 8.25222406587918e-05 0.00366560845783472 1.94889763134169 0.452380952380952 29.1 29 1 small cranium 0.000720393379427217 0.0198008677494497 1.94558880684026 0.451612903225806 29.1 29 1 abnormal dendritic spine morphology 1.61433720473311e-05 0.000923141102706579 1.94286389254497 0.450980392156863 29.1 29 1 limb grasping 5.12124700984406e-16 2.31620035217947e-13 1.94100735753059 0.450549450549451 29.1 29 1 abnormal vascular regression 0.00665513303025136 0.0882006005058989 1.93864027538726 0.45 29.1 29 1 abnormal circulating enzyme level 0.00665513303025136 0.0882006005058989 1.93864027538726 0.45 29.1 29 1 abnormal postnatal subventricular zone morphology 0.00665513303025136 0.0882006005058989 1.93864027538726 0.45 29.1 29 1 lordosis 0.00120925025539995 0.0278519445398832 1.93121253486854 0.448275862068966 29.1 29 1 impaired branching involved in ureteric bud morphogenesis 0.000228848425582616 0.00837147733289349 1.92730319775342 0.447368421052632 29.1 29 1 hyporesponsive to tactile stimuli 0.000228848425582616 0.00837147733289349 1.92730319775342 0.447368421052632 29.1 29 1 abnormal single cell response 0.00203223955731172 0.040815312395225 1.91470644482693 0.444444444444444 29.1 29 1 abnormal palate morphology 0.00203223955731172 0.040815312395225 1.91470644482693 0.444444444444444 29.1 29 1 abnormal bile duct morphology 0.0113645819525891 0.127053472391305 1.91470644482693 0.444444444444444 29.1 29 1 small thoracic cage 0.0113645819525891 0.127053472391305 1.91470644482693 0.444444444444444 29.1 29 1 abnormal nervous system electrophysiology 1.02572769115427e-07 1.08574367308351e-05 1.89761085156954 0.44047619047619 29.1 29 1 pancreatic islet hyperplasia 0.00106021535237128 0.0256047154274132 1.88478915662651 0.4375 29.1 29 1 abnormal auditory brainstem response waveform shape 0.00106021535237128 0.0256047154274132 1.88478915662651 0.4375 29.1 29 1 abnormal olfaction 0.0194814371235103 0.182523822390703 1.88478915662651 0.4375 29.1 29 1 dystonia 0.0194814371235103 0.182523822390703 1.88478915662651 0.4375 29.1 29 1 impaired behavioral response to addictive substance 0.0194814371235103 0.182523822390703 1.88478915662651 0.4375 29.1 29 1 increased susceptibility to pharmacologically induced seizures 1.84469149663724e-08 2.48036221507304e-06 1.88478915662651 0.4375 29.1 29 1 abnormal learning/memory/conditioning 2.10178485574158e-05 0.00113656300622982 1.87989360037553 0.436363636363636 29.1 29 1 abnormal response to injury 0.000334871968477299 0.0110330333985071 1.87788516704179 0.435897435897436 29.1 29 1 abnormal ulna morphology 0.00576263247545931 0.0804986974328308 1.87308239167852 0.434782608695652 29.1 29 1 decreased width of hypertrophic chondrocyte zone 0.000555121709543992 0.0161504707893647 1.86295762199377 0.432432432432432 29.1 29 1 abnormal calcium ion homeostasis 0.000555121709543992 0.0161504707893647 1.86295762199377 0.432432432432432 29.1 29 1 abnormal respiratory electron transport chain 0.000555121709543992 0.0161504707893647 1.86295762199377 0.432432432432432 29.1 29 1 abnormal response to novel object 5.68772415846345e-05 0.00262003960077367 1.85839154939084 0.431372549019608 29.1 29 1 ataxia 1.88724039181059e-15 7.22232380712131e-13 1.85546428997461 0.430693069306931 29.1 29 1 reduced long term potentiation 4.20194584702929e-09 6.96822686299024e-07 1.84632407179739 0.428571428571429 29.1 29 1 abnormal action potential 3.21967433293188e-06 0.000227605713316139 1.84632407179739 0.428571428571429 29.1 29 1 abnormal reproductive system morphology 0.000291608051527813 0.00980236524561398 1.84632407179739 0.428571428571429 29.1 29 1 shortened head 0.00295258725097839 0.0524249245117486 1.84632407179739 0.428571428571429 29.1 29 1 vascular ring 0.0097254349421453 0.112521020551565 1.84632407179739 0.428571428571429 29.1 29 1 extended life span 0.0335494497650053 0.245877232575422 1.84632407179739 0.428571428571429 29.1 29 1 increased hemangioma incidence 0.0335494497650053 0.245877232575422 1.84632407179739 0.428571428571429 29.1 29 1 decreased coping response 0.0335494497650053 0.245877232575422 1.84632407179739 0.428571428571429 29.1 29 1 abnormal decidualization 0.0335494497650053 0.245877232575422 1.84632407179739 0.428571428571429 29.1 29 1 abnormal viscerocranium morphology 0.0335494497650053 0.245877232575422 1.84632407179739 0.428571428571429 29.1 29 1 abnormal glucose tolerance 0.0335494497650053 0.245877232575422 1.84632407179739 0.428571428571429 29.1 29 1 decreased tongue size 0.0335494497650053 0.245877232575422 1.84632407179739 0.428571428571429 29.1 29 1 abnormal renal tubule epithelial cell primary cilium morphology 0.0335494497650053 0.245877232575422 1.84632407179739 0.428571428571429 29.1 29 1 abnormal locomotor coordination 0.00152485916015979 0.0337163303190887 1.82767433369843 0.424242424242424 29.1 29 1 ventricular hypoplasia 0.00492990826946492 0.073412123607313 1.82265325036409 0.423076923076923 29.1 29 1 abnormal ureter morphology 0.00492990826946492 0.073412123607313 1.82265325036409 0.423076923076923 29.1 29 1 abnormal cell migration 0.000252236314572993 0.00881948867088822 1.81897112258558 0.422222222222222 29.1 29 1 impaired balance 4.72279469314888e-08 5.46416362753853e-06 1.81615537781378 0.42156862745098 29.1 29 1 decreased neuron apoptosis 0.000792411370606814 0.0212667435786476 1.81393242141498 0.421052631578947 29.1 29 1 abnormal neurotransmitter level 0.0164400789197252 0.158814354612879 1.81393242141498 0.421052631578947 29.1 29 1 abnormal cochlear inner hair cell morphology 0.0164400789197252 0.158814354612879 1.81393242141498 0.421052631578947 29.1 29 1 increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 0.0164400789197252 0.158814354612879 1.81393242141498 0.421052631578947 29.1 29 1 abnormal cell morphology 8.43774772578215e-09 1.27205439199292e-06 1.81393242141498 0.421052631578947 29.1 29 1 impaired coordination 2.38238830096628e-23 1.97539696621787e-20 1.80541323012944 0.419075144508671 29.1 29 1 abnormal locomotor activation 3.7342147223969e-07 3.64268985174991e-05 1.79898242893079 0.417582417582418 29.1 29 1 abnormal limb bone morphology 0.00130498930584087 0.0297812926447629 1.79503729202524 0.416666666666667 29.1 29 1 decreased body height 0.00823339200278999 0.0991567390002977 1.79503729202524 0.416666666666667 29.1 29 1 increased stereotypic behavior 0.00823339200278999 0.0991567390002977 1.79503729202524 0.416666666666667 29.1 29 1 abnormal osteoblast morphology 0.00823339200278999 0.0991567390002977 1.79503729202524 0.416666666666667 29.1 29 1 abnormal esophagus morphology 0.0580984411486329 0.329202442727163 1.79503729202524 0.416666666666667 29.1 29 1 decreased digestive secretion 0.0580984411486329 0.329202442727163 1.79503729202524 0.416666666666667 29.1 29 1 mesocardia 0.0580984411486329 0.329202442727163 1.79503729202524 0.416666666666667 29.1 29 1 abnormal mating frequency 0.0580984411486329 0.329202442727163 1.79503729202524 0.416666666666667 29.1 29 1 impaired embryo implantation 0.0580984411486329 0.329202442727163 1.79503729202524 0.416666666666667 29.1 29 1 myocarditis 0.0580984411486329 0.329202442727163 1.79503729202524 0.416666666666667 29.1 29 1 increased growth rate 0.0580984411486329 0.329202442727163 1.79503729202524 0.416666666666667 29.1 29 1 increased circulating parathyroid hormone level 0.0580984411486329 0.329202442727163 1.79503729202524 0.416666666666667 29.1 29 1 abnormal rostral-caudal body axis extension 0.0580984411486329 0.329202442727163 1.79503729202524 0.416666666666667 29.1 29 1 abnormal B cell proliferation 0.0580984411486329 0.329202442727163 1.79503729202524 0.416666666666667 29.1 29 1 hematuria 0.0580984411486329 0.329202442727163 1.79503729202524 0.416666666666667 29.1 29 1 abnormal fatty acid level 0.0580984411486329 0.329202442727163 1.79503729202524 0.416666666666667 29.1 29 1 reduced cerebellar foliation 0.0580984411486329 0.329202442727163 1.79503729202524 0.416666666666667 29.1 29 1 abnormal colon goblet cell morphology 0.0580984411486329 0.329202442727163 1.79503729202524 0.416666666666667 29.1 29 1 abnormal posture 2.95237584251157e-06 0.000212870577050653 1.77708691910499 0.4125 29.1 29 1 hyperactivity 1.05168344531506e-23 1.04642502808848e-20 1.77665146531447 0.412398921832884 29.1 29 1 short maxilla 0.00214726469703869 0.0423914359832044 1.77391920623671 0.411764705882353 29.1 29 1 distended urinary bladder 0.0278379511554999 0.217415709573959 1.77391920623671 0.411764705882353 29.1 29 1 increased aggression towards mice 0.0278379511554999 0.217415709573959 1.77391920623671 0.411764705882353 29.1 29 1 hyperlipidemia 0.0278379511554999 0.217415709573959 1.77391920623671 0.411764705882353 29.1 29 1 abnormal glutamate-mediated receptor currents 0.0278379511554999 0.217415709573959 1.77391920623671 0.411764705882353 29.1 29 1 decreased vasoconstriction 0.0278379511554999 0.217415709573959 1.77391920623671 0.411764705882353 29.1 29 1 abnormal involuntary movement 0.0278379511554999 0.217415709573959 1.77391920623671 0.411764705882353 29.1 29 1 abnormal tarsal bone morphology 0.0278379511554999 0.217415709573959 1.77391920623671 0.411764705882353 29.1 29 1 increased trabecular bone mass 0.0278379511554999 0.217415709573959 1.77391920623671 0.411764705882353 29.1 29 1 abnormal spatial learning 3.84702342907935e-11 9.11378169508084e-09 1.77080979483227 0.411042944785276 29.1 29 1 intracerebral hemorrhage 0.0137515214860225 0.142528790402004 1.76240025035206 0.409090909090909 29.1 29 1 abnormal vascular branching morphogenesis 0.0137515214860225 0.142528790402004 1.76240025035206 0.409090909090909 29.1 29 1 decreased cardiac output 0.0137515214860225 0.142528790402004 1.76240025035206 0.409090909090909 29.1 29 1 abnormal limb posture 0.0137515214860225 0.142528790402004 1.76240025035206 0.409090909090909 29.1 29 1 lethargy 7.2161659511482e-07 6.52735011035678e-05 1.76029463476024 0.408602150537634 29.1 29 1 abnormal fetal cardiomyocyte proliferation 0.00692205550907025 0.0906242793621697 1.75514757442468 0.407407407407407 29.1 29 1 decreased bone ossification 0.00692205550907025 0.0906242793621697 1.75514757442468 0.407407407407407 29.1 29 1 increased circulating follicle stimulating hormone level 0.0035292821340533 0.0593206067565011 1.75016135972461 0.40625 29.1 29 1 increased trabecular bone volume 0.00181626266695238 0.0381261888948864 1.74652277061916 0.405405405405405 29.1 29 1 disheveled coat 0.000941318426686432 0.023227383534434 1.74375051225309 0.404761904761905 29.1 29 1 increased startle reflex 1.8608332024672e-06 0.000144650705973036 1.7425980003481 0.404494382022472 29.1 29 1 abnormal innervation 0.000490565466249286 0.0148814828938427 1.74156809609258 0.404255319148936 29.1 29 1 abnormal cell nucleus morphology 0.000490565466249286 0.0148814828938427 1.74156809609258 0.404255319148936 29.1 29 1 abnormal myocardial trabeculae morphology 0.00079509835289014 0.0212667435786476 1.72323580034423 0.4 29.1 29 1 lethality at weaning, complete penetrance 0.00079509835289014 0.0212667435786476 1.72323580034423 0.4 29.1 29 1 impaired righting response 1.3545212673977e-06 0.000114215988225484 1.72323580034423 0.4 29.1 29 1 kidney inflammation 0.000415118210735419 0.0133239554736046 1.72323580034423 0.4 29.1 29 1 abnormal hippocampus pyramidal cell morphology 0.00296535161722738 0.0524249245117486 1.72323580034423 0.4 29.1 29 1 decreased bone volume 0.00296535161722738 0.0524249245117486 1.72323580034423 0.4 29.1 29 1 abnormal response to new environment 0.00579267008662381 0.0804986974328308 1.72323580034423 0.4 29.1 29 1 abnormal nest building behavior 0.0114424931913499 0.127637676293645 1.72323580034423 0.4 29.1 29 1 abnormal dopamine level 0.0229633761793744 0.196293464763553 1.72323580034423 0.4 29.1 29 1 abnormal hearing physiology 0.0229633761793744 0.196293464763553 1.72323580034423 0.4 29.1 29 1 abnormal trachea morphology 0.0229633761793744 0.196293464763553 1.72323580034423 0.4 29.1 29 1 abnormal lens epithelium morphology 0.0229633761793744 0.196293464763553 1.72323580034423 0.4 29.1 29 1 spleen atrophy 0.0229633761793744 0.196293464763553 1.72323580034423 0.4 29.1 29 1 kidney atrophy 0.0229633761793744 0.196293464763553 1.72323580034423 0.4 29.1 29 1 enhanced behavioral response to xenobiotic 0.0229633761793744 0.196293464763553 1.72323580034423 0.4 29.1 29 1 abnormal fontanelle morphology 0.0472176037050203 0.292902217496853 1.72323580034423 0.4 29.1 29 1 macrocytosis 0.0472176037050203 0.292902217496853 1.72323580034423 0.4 29.1 29 1 abnormal prostate gland morphology 0.0472176037050203 0.292902217496853 1.72323580034423 0.4 29.1 29 1 altered righting response 0.0472176037050203 0.292902217496853 1.72323580034423 0.4 29.1 29 1 decreased aggression towards males 0.0472176037050203 0.292902217496853 1.72323580034423 0.4 29.1 29 1 immune system phenotype 0.0472176037050203 0.292902217496853 1.72323580034423 0.4 29.1 29 1 abnormal neurotransmitter secretion 0.0472176037050203 0.292902217496853 1.72323580034423 0.4 29.1 29 1 abnormal energy homeostasis 0.0472176037050203 0.292902217496853 1.72323580034423 0.4 29.1 29 1 bicuspid aortic valve 0.0472176037050203 0.292902217496853 1.72323580034423 0.4 29.1 29 1 abnormal branching involved in lung morphogenesis 0.0472176037050203 0.292902217496853 1.72323580034423 0.4 29.1 29 1 seminiferous tubule degeneration 2.70892099371105e-05 0.00140384186913672 1.71143281541037 0.397260273972603 29.1 29 1 increased circulating creatinine level 6.47358879342524e-06 0.000396122552097573 1.70319817475884 0.395348837209302 29.1 29 1 abnormal skeleton development 1.21774443545674e-05 0.000704450996092705 1.7019612842906 0.395061728395062 29.1 29 1 abnormal motor capabilities/coordination/movement 3.09871608313184e-08 3.76002744233681e-06 1.69712616700569 0.393939393939394 29.1 29 1 abnormal ovarian folliculogenesis 0.00483215706708409 0.0730698523062108 1.69712616700569 0.393939393939394 29.1 29 1 decreased brown adipose tissue amount 0.00483215706708409 0.0730698523062108 1.69712616700569 0.393939393939394 29.1 29 1 abnormal motor coordination/ balance 1.55803787345506e-06 0.000126294319737552 1.69712616700568 0.393939393939394 29.1 29 1 abnormal maternal nurturing 0.000155248054786875 0.00623756269448152 1.69498603312548 0.39344262295082 29.1 29 1 increased circulating luteinizing hormone level 0.00949053497018849 0.110153652260754 1.69246373248094 0.392857142857143 29.1 29 1 abnormal mitotic spindle morphology 0.00949053497018849 0.110153652260754 1.69246373248094 0.392857142857143 29.1 29 1 kidney cysts 3.65755177700181e-05 0.00185935308182438 1.68830534493185 0.391891891891892 29.1 29 1 abnormal locomotor behavior 4.63986971241245e-06 0.000299783789860415 1.68577415251066 0.391304347826087 29.1 29 1 abnormal carpal bone morphology 0.018887235849956 0.177962118093809 1.68577415251066 0.391304347826087 29.1 29 1 liver fibrosis 0.00207606337905869 0.0412869519736013 1.68120565887242 0.390243902439024 29.1 29 1 abnormal axon morphology 9.44702115493233e-07 8.39266611531935e-05 1.67536813922356 0.388888888888889 29.1 29 1 abnormal chondrocyte morphology 0.000472450646239387 0.0145990184164034 1.67536813922356 0.388888888888889 29.1 29 1 neurodegeneration 0.000472450646239387 0.0145990184164034 1.67536813922356 0.388888888888889 29.1 29 1 abnormal mitral valve morphology 0.038321004284625 0.259562220922599 1.67536813922356 0.388888888888889 29.1 29 1 cortical renal glomerulopathies 0.038321004284625 0.259562220922599 1.67536813922356 0.388888888888889 29.1 29 1 abnormal phrenic nerve morphology 0.038321004284625 0.259562220922599 1.67536813922356 0.388888888888889 29.1 29 1 blepharoptosis 0.038321004284625 0.259562220922599 1.67536813922356 0.388888888888889 29.1 29 1 abnormal body wall morphology 0.038321004284625 0.259562220922599 1.67536813922356 0.388888888888889 29.1 29 1 decreased lactate dehydrogenase level 0.038321004284625 0.259562220922599 1.67536813922356 0.388888888888889 29.1 29 1 decreased pulmonary respiratory rate 0.038321004284625 0.259562220922599 1.67536813922356 0.388888888888889 29.1 29 1 abnormal metanephric mesenchyme morphology 0.038321004284625 0.259562220922599 1.67536813922356 0.388888888888889 29.1 29 1 abnormal capillary morphology 0.00785568882302094 0.098486792483631 1.66764754872023 0.387096774193548 29.1 29 1 pale kidney 0.00785568882302094 0.098486792483631 1.66764754872023 0.387096774193548 29.1 29 1 postnatal lethality 2.3660522276684e-09 4.05900339056907e-07 1.66095016900649 0.385542168674699 29.1 29 1 no spontaneous movement 0.0155128587675281 0.151623717816213 1.65695750033099 0.384615384615385 29.1 29 1 decreased circulating glycerol level 0.0155128587675281 0.151623717816213 1.65695750033099 0.384615384615385 29.1 29 1 abnormal nerve conduction 0.0155128587675281 0.151623717816213 1.65695750033099 0.384615384615385 29.1 29 1 increased circulating adrenocorticotropin level 0.0802071373511664 0.4135188893344 1.65695750033099 0.384615384615385 29.1 29 1 abnormal pulmonary alveolus epithelial cell morphology 0.0802071373511664 0.4135188893344 1.65695750033099 0.384615384615385 29.1 29 1 decreased endocochlear potential 0.0802071373511664 0.4135188893344 1.65695750033099 0.384615384615385 29.1 29 1 increased circulating thyroxine level 0.0802071373511664 0.4135188893344 1.65695750033099 0.384615384615385 29.1 29 1 increased renin activity 0.0802071373511664 0.4135188893344 1.65695750033099 0.384615384615385 29.1 29 1 orthokeratosis 0.0802071373511664 0.4135188893344 1.65695750033099 0.384615384615385 29.1 29 1 abnormal kidney development 0.000331309979552089 0.0109884476551443 1.65143430866322 0.383333333333333 29.1 29 1 abnormal tibia morphology 0.00144331747874595 0.032344614670095 1.64990661735086 0.382978723404255 29.1 29 1 decreased anxiety-related response 4.03128679289059e-07 3.85685611435205e-05 1.64618054097925 0.382113821138211 29.1 29 1 abnormal gait 1.25577404970068e-15 5.20622991438406e-13 1.6451603919144 0.381877022653722 29.1 29 1 abnormal embryo turning 0.000629844970763153 0.0175054677628306 1.64490690032859 0.381818181818182 29.1 29 1 gliosis 0.000277001621160553 0.00943892510461473 1.64117695270879 0.380952380952381 29.1 29 1 small ears 0.0311098015561308 0.240701808307544 1.64117695270879 0.380952380952381 29.1 29 1 abnormal scapula morphology 0.0311098015561308 0.240701808307544 1.64117695270879 0.380952380952381 29.1 29 1 abnormal salivary gland morphology 0.0311098015561308 0.240701808307544 1.64117695270879 0.380952380952381 29.1 29 1 abnormal axon extension 0.00120142879478821 0.0278005035073086 1.63707401032702 0.38 29.1 29 1 hunched posture 5.44766372715285e-05 0.0025435684854504 1.63598335475718 0.379746835443038 29.1 29 1 decreased trophoblast giant cell number 0.0127339197416785 0.138624180995297 1.63410291411953 0.379310344827586 29.1 29 1 increased white adipose tissue amount 0.00536453555790509 0.0762530411445081 1.63008791924455 0.378378378378378 29.1 29 1 increased circulating phosphate level 0.00536453555790509 0.0762530411445081 1.63008791924455 0.378378378378378 29.1 29 1 increased bone mineral content 3.43284837077931e-06 0.000237200286730932 1.6204740324338 0.376146788990826 29.1 29 1 scoliosis 0.0104515328364015 0.1179056141975 1.61553356282272 0.375 29.1 29 1 abnormal heart atrium morphology 0.0104515328364015 0.1179056141975 1.61553356282272 0.375 29.1 29 1 bradykinesia 0.0104515328364015 0.1179056141975 1.61553356282272 0.375 29.1 29 1 increased fibroblast apoptosis 0.0104515328364015 0.1179056141975 1.61553356282272 0.375 29.1 29 1 abnormal tympanic ring morphology 0.0638593036539263 0.35497210690311 1.61553356282272 0.375 29.1 29 1 poor circulation 0.0638593036539263 0.35497210690311 1.61553356282272 0.375 29.1 29 1 disorganized yolk sac vascular plexus 0.0638593036539263 0.35497210690311 1.61553356282272 0.375 29.1 29 1 intraventricular hemorrhage 0.0638593036539263 0.35497210690311 1.61553356282272 0.375 29.1 29 1 abnormal meiosis 0.0638593036539263 0.35497210690311 1.61553356282272 0.375 29.1 29 1 abnormal pulmonary elastic fiber morphology 0.0638593036539263 0.35497210690311 1.61553356282272 0.375 29.1 29 1 abnormal epididymis epithelium morphology 0.0638593036539263 0.35497210690311 1.61553356282272 0.375 29.1 29 1 decreased circulating growth hormone level 0.0638593036539263 0.35497210690311 1.61553356282272 0.375 29.1 29 1 abnormal Langerhans cell physiology 0.0638593036539263 0.35497210690311 1.61553356282272 0.375 29.1 29 1 abnormal thoracic cage shape 0.0638593036539263 0.35497210690311 1.61553356282272 0.375 29.1 29 1 abnormal forebrain development 0.000161165496077224 0.0064143867438735 1.61553356282272 0.375 29.1 29 1 small heart 0.00190742866955461 0.0398716707186311 1.61553356282272 0.375 29.1 29 1 abnormal pancreatic beta cell morphology 0.0044293126504869 0.0707266031985899 1.61553356282272 0.375 29.1 29 1 abnormal startle reflex 0.0252795421582556 0.214556255890999 1.61553356282272 0.375 29.1 29 1 ventricular septal defect 2.63838475162256e-07 2.67876819169842e-05 1.61553356282272 0.375 29.1 29 1 infertility 5.35702051039736e-06 0.000341681756913165 1.61050074798527 0.373831775700935 29.1 29 1 decreased white adipose tissue amount 0.000303664547041423 0.0101391350438327 1.60749608241067 0.373134328358209 29.1 29 1 distended abdomen 0.00158047795488314 0.0347914948032903 1.60497451992845 0.372549019607843 29.1 29 1 abnormal blood circulation 0.00365623804852271 0.0606835900371313 1.60301004683185 0.372093023255814 29.1 29 1 abnormal liver development 0.0085794815609835 0.101144489112986 1.60014752889107 0.371428571428571 29.1 29 1 decreased bone mineralization 0.0085794815609835 0.101144489112986 1.60014752889107 0.371428571428571 29.1 29 1 abnormal myocardial fiber morphology 1.86043945278641e-05 0.00102840958640138 1.59887857763898 0.371134020618557 29.1 29 1 pericardial effusion 0.000573206619383796 0.0164838319736092 1.59816223419022 0.370967741935484 29.1 29 1 abnormal behavior 7.18871451615663e-13 2.38425698119195e-10 1.59616265679367 0.370503597122302 29.1 29 1 abnormal heart valve morphology 0.0205662724489738 0.19089030864486 1.59558870402244 0.37037037037037 29.1 29 1 abnormal atrioventricular cushion morphology 0.0205662724489738 0.19089030864486 1.59558870402244 0.37037037037037 29.1 29 1 abnormal brain commissure morphology 0.0205662724489738 0.19089030864486 1.59558870402244 0.37037037037037 29.1 29 1 increased neuron apoptosis 9.33363714697578e-05 0.00410927830143403 1.59558870402244 0.37037037037037 29.1 29 1 decreased grip strength 2.13041722811365e-10 4.07647142687131e-08 1.59340296607172 0.36986301369863 29.1 29 1 abnormal fertility/fecundity 0.000210240559319746 0.00783825057256167 1.59340296607172 0.36986301369863 29.1 29 1 astrocytosis 0.000210240559319746 0.00783825057256167 1.59340296607172 0.36986301369863 29.1 29 1 abnormal myelin sheath morphology 0.00301780173436804 0.0524949777219616 1.59212003292674 0.369565217391304 29.1 29 1 atrial septal defect 0.00301780173436804 0.0524949777219616 1.59212003292674 0.369565217391304 29.1 29 1 decreased hair follicle number 0.007044852765612 0.0915095104671532 1.58719086873811 0.368421052631579 29.1 29 1 increased grooming behavior 0.007044852765612 0.0915095104671532 1.58719086873811 0.368421052631579 29.1 29 1 abnormal retinal outer nuclear layer morphology 0.007044852765612 0.0915095104671532 1.58719086873811 0.368421052631579 29.1 29 1 enlarged adrenal glands 0.05108487741415 0.301837607049164 1.58719086873811 0.368421052631579 29.1 29 1 thin dermal layer 0.05108487741415 0.301837607049164 1.58719086873811 0.368421052631579 29.1 29 1 abnormal stationary movement 0.05108487741415 0.301837607049164 1.58719086873811 0.368421052631579 29.1 29 1 unresponsive to tactile stimuli 0.05108487741415 0.301837607049164 1.58719086873811 0.368421052631579 29.1 29 1 abnormal sternebra morphology 0.05108487741415 0.301837607049164 1.58719086873811 0.368421052631579 29.1 29 1 right-sided stomach 0.05108487741415 0.301837607049164 1.58719086873811 0.368421052631579 29.1 29 1 incomplete embryo turning 0.00108428784298471 0.0259342885521584 1.58719086873811 0.368421052631579 29.1 29 1 decreased startle reflex 4.05821897782943e-06 0.000276570402941115 1.58331494476073 0.367521367521368 29.1 29 1 abnormal long bone hypertrophic chondrocyte zone 0.00249085970635192 0.0469394963602302 1.58256349011205 0.36734693877551 29.1 29 1 abnormal placenta morphology 0.000145394213009027 0.00592898532557303 1.58145057626528 0.367088607594937 29.1 29 1 preweaning lethality, incomplete penetrance 1.32214072890408e-17 6.57765012629779e-15 1.579983924521 0.366748166259169 29.1 29 1 abnormal optic cup morphology 0.0167525379630258 0.161206724112289 1.57963281698221 0.366666666666667 29.1 29 1 short humerus 0.00578695646092621 0.0804986974328308 1.5761303051929 0.365853658536585 29.1 29 1 palatal shelves fail to meet at midline 0.00578695646092621 0.0804986974328308 1.5761303051929 0.365853658536585 29.1 29 1 abnormal testis morphology 6.27209877762617e-06 0.000390046142733628 1.57338920900995 0.365217391304348 29.1 29 1 decreased body length 4.36451254273265e-12 1.158988424434e-09 1.57229543827029 0.364963503649635 29.1 29 1 decreased circulating total protein level 0.00169740673121496 0.035934461650189 1.56657800031294 0.363636363636364 29.1 29 1 abnormal photoreceptor outer segment morphology 0.00475571531147322 0.0726418845135352 1.56657800031294 0.363636363636364 29.1 29 1 decreased blood urea nitrogen level 0.00475571531147322 0.0726418845135352 1.56657800031294 0.363636363636364 29.1 29 1 embryonic lethality, incomplete penetrance 0.00475571531147322 0.0726418845135352 1.56657800031294 0.363636363636364 29.1 29 1 belly spot 0.0136626047045829 0.142528790402004 1.56657800031294 0.363636363636364 29.1 29 1 abnormal skeleton physiology 0.0136626047045829 0.142528790402004 1.56657800031294 0.363636363636364 29.1 29 1 single kidney 0.0136626047045829 0.142528790402004 1.56657800031294 0.363636363636364 29.1 29 1 abnormal occipital bone morphology 0.0410288187390498 0.269641179956107 1.56657800031294 0.363636363636364 29.1 29 1 increased mammary gland tumor incidence 0.0410288187390498 0.269641179956107 1.56657800031294 0.363636363636364 29.1 29 1 abnormal neural tube closure 0.00015546889931974 0.00623756269448152 1.55714078344359 0.36144578313253 29.1 29 1 abnormal pharyngeal arch morphology 0.0111554800258885 0.125278810674481 1.55569898642188 0.361111111111111 29.1 29 1 kyphosis 5.50193329878725e-07 5.06891077064196e-05 1.55091222030981 0.36 29.1 29 1 abnormal hindlimb morphology 0.0032161645941065 0.0555388871471217 1.55091222030981 0.36 29.1 29 1 abnormal thyroid gland morphology 0.03306288220214 0.245877232575422 1.55091222030981 0.36 29.1 29 1 decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 0.03306288220214 0.245877232575422 1.55091222030981 0.36 29.1 29 1 lymphoid hyperplasia 0.0267194599371879 0.217415709573959 1.53860339316449 0.357142857142857 29.1 29 1 abnormal ovulation 0.0267194599371879 0.217415709573959 1.53860339316449 0.357142857142857 29.1 29 1 abnormal hormone level 0.0267194599371879 0.217415709573959 1.53860339316449 0.357142857142857 29.1 29 1 abnormal blood flow velocity 0.106128074899034 0.467245285506807 1.53860339316449 0.357142857142857 29.1 29 1 abnormal kidney blood vessel morphology 0.106128074899034 0.467245285506807 1.53860339316449 0.357142857142857 29.1 29 1 irregularly shaped pupil 0.106128074899034 0.467245285506807 1.53860339316449 0.357142857142857 29.1 29 1 increased aggression towards males 0.106128074899034 0.467245285506807 1.53860339316449 0.357142857142857 29.1 29 1 abnormal ventral body wall morphology 0.106128074899034 0.467245285506807 1.53860339316449 0.357142857142857 29.1 29 1 absent olfactory bulb 0.106128074899034 0.467245285506807 1.53860339316449 0.357142857142857 29.1 29 1 abnormal voluntary movement 0.106128074899034 0.467245285506807 1.53860339316449 0.357142857142857 29.1 29 1 abnormal sagittal suture morphology 0.106128074899034 0.467245285506807 1.53860339316449 0.357142857142857 29.1 29 1 abnormal positive T cell selection 0.106128074899034 0.467245285506807 1.53860339316449 0.357142857142857 29.1 29 1 increased circulating growth hormone level 0.106128074899034 0.467245285506807 1.53860339316449 0.357142857142857 29.1 29 1 spina bifida occulta 0.106128074899034 0.467245285506807 1.53860339316449 0.357142857142857 29.1 29 1 abnormal respiratory motile cilium physiology 0.106128074899034 0.467245285506807 1.53860339316449 0.357142857142857 29.1 29 1 testis degeneration 0.106128074899034 0.467245285506807 1.53860339316449 0.357142857142857 29.1 29 1 abnormal vitelline vein topology 0.106128074899034 0.467245285506807 1.53860339316449 0.357142857142857 29.1 29 1 decreased response to antigen 0.106128074899034 0.467245285506807 1.53860339316449 0.357142857142857 29.1 29 1 irregular heartbeat 0.00610999753796019 0.0844367715315332 1.53176515586154 0.355555555555556 29.1 29 1 increased circulating corticosterone level 0.00610999753796019 0.0844367715315332 1.53176515586154 0.355555555555556 29.1 29 1 abnormal object recognition memory 0.0216458049900286 0.196293464763553 1.52867691966021 0.354838709677419 29.1 29 1 preaxial polydactyly 0.0216458049900286 0.196293464763553 1.52867691966021 0.354838709677419 29.1 29 1 hypoglycemia 0.000112964030016809 0.00476267838418325 1.52867691966021 0.354838709677419 29.1 29 1 overriding aortic valve 0.00500819895548899 0.0741541363201123 1.52578169822146 0.354166666666667 29.1 29 1 abnormal embryo size 2.40539262368381e-05 0.00125966613713968 1.52498743393295 0.353982300884956 29.1 29 1 small lung 0.00410835730641016 0.0675306357780457 1.52050217677432 0.352941176470588 29.1 29 1 abnormal lung development 0.000252200204371479 0.00881948867088822 1.52050217677432 0.352941176470588 29.1 29 1 abnormal oocyte morphology 0.0175726254728137 0.167654424017439 1.52050217677432 0.352941176470588 29.1 29 1 abnormal brown adipose tissue morphology 0.0175726254728137 0.167654424017439 1.52050217677432 0.352941176470588 29.1 29 1 increased width of hypertrophic chondrocyte zone 0.0175726254728137 0.167654424017439 1.52050217677432 0.352941176470588 29.1 29 1 abnormal interatrial septum morphology 0.0835073141076133 0.422627455994146 1.52050217677432 0.352941176470588 29.1 29 1 abnormal urinary bladder morphology 0.0835073141076133 0.422627455994146 1.52050217677432 0.352941176470588 29.1 29 1 abnormal vagus nerve morphology 0.0835073141076133 0.422627455994146 1.52050217677432 0.352941176470588 29.1 29 1 abnormal dorsal-ventral axis patterning 0.0835073141076133 0.422627455994146 1.52050217677432 0.352941176470588 29.1 29 1 coloboma 0.0835073141076133 0.422627455994146 1.52050217677432 0.352941176470588 29.1 29 1 abnormal electroretinogram waveform feature 0.0835073141076133 0.422627455994146 1.52050217677432 0.352941176470588 29.1 29 1 decreased body fat mass 0.0835073141076133 0.422627455994146 1.52050217677432 0.352941176470588 29.1 29 1 abnormal cell cytoskeleton morphology 0.0835073141076133 0.422627455994146 1.52050217677432 0.352941176470588 29.1 29 1 increased circulating HDL cholesterol level 5.32936236124199e-05 0.00252510264258846 1.51808868125563 0.352380952380952 29.1 29 1 abnormal long bone epiphyseal plate proliferative zone 0.00337267998858547 0.0574626128192216 1.51580926882132 0.351851851851852 29.1 29 1 abnormal osteoblast physiology 0.00337267998858547 0.0574626128192216 1.51580926882132 0.351851851851852 29.1 29 1 axon degeneration 0.00337267998858547 0.0574626128192216 1.51580926882132 0.351851851851852 29.1 29 1 increased blood urea nitrogen level 2.46695089564419e-06 0.000185955768270149 1.51525906581993 0.351724137931034 29.1 29 1 abnormal hepatocyte morphology 3.66264526670933e-05 0.00185935308182438 1.51365306786994 0.351351351351351 29.1 29 1 abnormal vocalization 0.0142922416127129 0.147518468927897 1.51365306786994 0.351351351351351 29.1 29 1 abnormal cranium morphology 6.52905513005046e-06 0.000396122552097573 1.51104631746603 0.350746268656716 29.1 29 1 abnormal incisor morphology 0.00227749702184619 0.0439168514871504 1.5078313253012 0.35 29.1 29 1 increased mammary adenocarcinoma incidence 0.0662272242328752 0.363664945428867 1.5078313253012 0.35 29.1 29 1 anencephaly 0.0662272242328752 0.363664945428867 1.5078313253012 0.35 29.1 29 1 abnormal sperm mitochondrial sheath morphology 0.0662272242328752 0.363664945428867 1.5078313253012 0.35 29.1 29 1 abnormal craniofacial morphology 8.10716570773215e-05 0.00363361706269977 1.50574001971826 0.349514563106796 29.1 29 1 abnormal left-right axis patterning 0.00949867674771125 0.110153652260754 1.50282191890486 0.348837209302326 29.1 29 1 delayed endochondral bone ossification 0.00949867674771125 0.110153652260754 1.50282191890486 0.348837209302326 29.1 29 1 failure to gastrulate 0.00775916863320934 0.098486792483631 1.49846591334281 0.347826086956522 29.1 29 1 embryonic lethality between implantation and placentation, complete penetrance 0.00775916863320934 0.098486792483631 1.49846591334281 0.347826086956522 29.1 29 1 blistering 0.0528376629465665 0.306729723639636 1.49846591334281 0.347826086956522 29.1 29 1 abnormal circulating insulin level 0.0528376629465665 0.306729723639636 1.49846591334281 0.347826086956522 29.1 29 1 abnormal postnatal growth 0.0528376629465665 0.306729723639636 1.49846591334281 0.347826086956522 29.1 29 1 pancreas inflammation 0.0528376629465665 0.306729723639636 1.49846591334281 0.347826086956522 29.1 29 1 abnormal cochlear ganglion morphology 0.0528376629465665 0.306729723639636 1.49846591334281 0.347826086956522 29.1 29 1 increased susceptibility to age related obesity 0.0528376629465665 0.306729723639636 1.49846591334281 0.347826086956522 29.1 29 1 abnormal corneal stroma morphology 0.0528376629465665 0.306729723639636 1.49846591334281 0.347826086956522 29.1 29 1 abnormal chondrocyte physiology 0.0528376629465665 0.306729723639636 1.49846591334281 0.347826086956522 29.1 29 1 abnormal palatal shelf fusion at midline 0.0528376629465665 0.306729723639636 1.49846591334281 0.347826086956522 29.1 29 1 hydrops fetalis 0.00104559251664882 0.0254991312270976 1.49586441002104 0.347222222222222 29.1 29 1 postnatal lethality, complete penetrance 9.23936450275259e-14 3.28327417151387e-11 1.49555438630911 0.347150259067358 29.1 29 1 decreased circulating creatinine level 0.00634553543159302 0.0874488608647515 1.49464329621694 0.346938775510204 29.1 29 1 abnormal neurocranium morphology 0.000861704285169054 0.022563046414295 1.493471026965 0.346666666666667 29.1 29 1 decreased bone mineral content 5.04995305672728e-08 5.60161263455307e-06 1.49126175029789 0.346153846153846 29.1 29 1 abnormal heart ventricle morphology 0.000710453169908341 0.0196361362238555 1.49126175029789 0.346153846153846 29.1 29 1 eyelids open at birth 0.0051948553840096 0.0760129574571993 1.49126175029789 0.346153846153846 29.1 29 1 abnormal placenta vasculature 0.0051948553840096 0.0760129574571993 1.49126175029789 0.346153846153846 29.1 29 1 abnormal stomach morphology 0.0423540710792876 0.276887652587984 1.49126175029789 0.346153846153846 29.1 29 1 prenatal lethality, incomplete penetrance 5.8758711257419e-11 1.27097647176374e-08 1.48799143944198 0.345394736842105 29.1 29 1 postnatal lethality, incomplete penetrance 3.90396312142518e-19 2.77460236129861e-16 1.48659426438147 0.345070422535211 29.1 29 1 decreased retinal photoreceptor cell number 0.0340802705664036 0.245877232575422 1.48554810374503 0.344827586206897 29.1 29 1 short sternum 0.0340802705664036 0.245877232575422 1.48554810374503 0.344827586206897 29.1 29 1 abnormal CD8-positive, alpha-beta T cell physiology 0.0340802705664036 0.245877232575422 1.48554810374503 0.344827586206897 29.1 29 1 polychromatophilia 0.0340802705664036 0.245877232575422 1.48554810374503 0.344827586206897 29.1 29 1 kidney cortex cysts 0.0275094713562141 0.217415709573959 1.48090576592083 0.34375 29.1 29 1 failure of primitive streak formation 0.0275094713562141 0.217415709573959 1.48090576592083 0.34375 29.1 29 1 neonatal lethality 0.0275094713562141 0.217415709573959 1.48090576592083 0.34375 29.1 29 1 abnormal serotonin level 0.0275094713562141 0.217415709573959 1.48090576592083 0.34375 29.1 29 1 impaired fertilization 0.00159101619998233 0.0348110499683149 1.47705925743791 0.342857142857143 29.1 29 1 ovary cysts 0.0222647005572468 0.196293464763553 1.47705925743791 0.342857142857143 29.1 29 1 increased circulating serum albumin level 0.0222647005572468 0.196293464763553 1.47705925743791 0.342857142857143 29.1 29 1 impaired adaptive thermogenesis 0.0222647005572468 0.196293464763553 1.47705925743791 0.342857142857143 29.1 29 1 incomplete somite formation 0.0180608838132052 0.170822998043148 1.47382009239967 0.342105263157895 29.1 29 1 abnormal reproductive system physiology 0.0180608838132052 0.170822998043148 1.47382009239967 0.342105263157895 29.1 29 1 abnormal brain morphology 2.85596871568127e-06 0.000208947711184034 1.47170759346169 0.341614906832298 29.1 29 1 abnormal cell differentiation 0.0146796381471015 0.148739714423279 1.47105495151337 0.341463414634146 29.1 29 1 lethality at weaning, incomplete penetrance 0.0146796381471015 0.148739714423279 1.47105495151337 0.341463414634146 29.1 29 1 muscular atrophy 0.0119519326630068 0.131587106181795 1.46866687529338 0.340909090909091 29.1 29 1 omphalocele 0.0119519326630068 0.131587106181795 1.46866687529338 0.340909090909091 29.1 29 1 reduced female fertility 2.64417729730618e-08 3.46178475107849e-06 1.46697875244822 0.34051724137931 29.1 29 1 decreased body size 8.74626870988818e-25 1.45042289438979e-21 1.46302287560554 0.339598997493734 29.1 29 1 abnormal colon morphology 0.00436125571401852 0.0705603263460902 1.46036932232562 0.338983050847458 29.1 29 1 postnatal growth retardation 5.26671454241173e-19 3.27523810606229e-16 1.45714791940873 0.338235294117647 29.1 29 1 reduced fertility 1.96373743049163e-05 0.00107358172710943 1.45669213338451 0.338129496402878 29.1 29 1 abnormal skeletal muscle fiber morphology 0.00198006645734545 0.040815312395225 1.4562556059247 0.338028169014085 29.1 29 1 pale liver 0.00162813511870347 0.0353710577098243 1.45543564218263 0.337837837837838 29.1 29 1 decreased body weight 3.94358852884967e-37 1.96193529310271e-33 1.45458918526634 0.337641357027464 29.1 29 1 abnormal social investigation 0.00110267932654284 0.0261229983311934 1.45398020654045 0.3375 29.1 29 1 abnormal muscle physiology 0.000616850750048406 0.0172406319184878 1.45216500029008 0.337078651685393 29.1 29 1 hypoactivity 4.42628745009969e-12 1.158988424434e-09 1.45126622442784 0.336870026525199 29.1 29 1 premature death 8.3919831047179e-26 2.08750579729858e-22 1.45104059843156 0.336817653890825 29.1 29 1 decreased bone mineral density 9.47897050085998e-09 1.38699641887584e-06 1.44142844201726 0.334586466165414 29.1 29 1 abnormal apoptosis 0.00807170800310702 0.0989082446193532 1.4360298336202 0.333333333333333 29.1 29 1 abnormal cell adhesion 0.00807170800310702 0.0989082446193532 1.4360298336202 0.333333333333333 29.1 29 1 abnormal trigeminal nerve morphology 0.0532479703944445 0.30731862263615 1.4360298336202 0.333333333333333 29.1 29 1 increased brain weight 0.0532479703944445 0.30731862263615 1.4360298336202 0.333333333333333 29.1 29 1 abnormal type II pneumocyte morphology 0.0532479703944445 0.30731862263615 1.4360298336202 0.333333333333333 29.1 29 1 abnormal skin appearance 0.0532479703944445 0.30731862263615 1.4360298336202 0.333333333333333 29.1 29 1 abnormal bone trabecula morphology 0.0532479703944445 0.30731862263615 1.4360298336202 0.333333333333333 29.1 29 1 increased mean corpuscular hemoglobin 0.000426615299683313 0.0135185421396464 1.4360298336202 0.333333333333333 29.1 29 1 decreased insulin secretion 0.000760529782951547 0.0207892069790327 1.4360298336202 0.333333333333333 29.1 29 1 increased exploration in new environment 0.0013610289975693 0.0306385487009379 1.4360298336202 0.333333333333333 29.1 29 1 abnormal cornea morphology 0.00165407146050888 0.0354363411605138 1.4360298336202 0.333333333333333 29.1 29 1 perimembraneous ventricular septal defect 0.00297972906879118 0.0524249245117486 1.4360298336202 0.333333333333333 29.1 29 1 abnormal vascular development 0.00363061169113184 0.0606117220247682 1.4360298336202 0.333333333333333 29.1 29 1 decreased brain weight 0.00660052192971416 0.0882006005058989 1.4360298336202 0.333333333333333 29.1 29 1 thymus atrophy 0.0121146476558028 0.132754123541011 1.4360298336202 0.333333333333333 29.1 29 1 abnormal cartilage development 0.0148729002255302 0.14917878754438 1.4360298336202 0.333333333333333 29.1 29 1 trabecula carnea hypoplasia 0.0148729002255302 0.14917878754438 1.4360298336202 0.333333333333333 29.1 29 1 enlarged pericardium 0.0344329046820297 0.245877232575422 1.4360298336202 0.333333333333333 29.1 29 1 dextrocardia 0.0344329046820297 0.245877232575422 1.4360298336202 0.333333333333333 29.1 29 1 decreased systemic arterial blood pressure 0.0344329046820297 0.245877232575422 1.4360298336202 0.333333333333333 29.1 29 1 diarrhea 0.0344329046820297 0.245877232575422 1.4360298336202 0.333333333333333 29.1 29 1 abnormal hair cycle 0.0427441368680923 0.277613682661566 1.4360298336202 0.333333333333333 29.1 29 1 abnormal lactation 0.0427441368680923 0.277613682661566 1.4360298336202 0.333333333333333 29.1 29 1 disorganized myocardium 0.0427441368680923 0.277613682661566 1.4360298336202 0.333333333333333 29.1 29 1 abnormal body weight 0.066616723340722 0.364596478129914 1.4360298336202 0.333333333333333 29.1 29 1 abnormal vasodilation 0.066616723340722 0.364596478129914 1.4360298336202 0.333333333333333 29.1 29 1 hypopigmentation 0.066616723340722 0.364596478129914 1.4360298336202 0.333333333333333 29.1 29 1 abnormal anxiety-related response 0.0837859355712474 0.422627455994146 1.4360298336202 0.333333333333333 29.1 29 1 liver degeneration 0.0837859355712474 0.422627455994146 1.4360298336202 0.333333333333333 29.1 29 1 absent incisors 0.13558331049604 0.534044845004636 1.4360298336202 0.333333333333333 29.1 29 1 decreased chondrocyte number 0.13558331049604 0.534044845004636 1.4360298336202 0.333333333333333 29.1 29 1 interdigital webbing 0.13558331049604 0.534044845004636 1.4360298336202 0.333333333333333 29.1 29 1 decreased hepatocyte number 0.13558331049604 0.534044845004636 1.4360298336202 0.333333333333333 29.1 29 1 hyperpigmentation 0.13558331049604 0.534044845004636 1.4360298336202 0.333333333333333 29.1 29 1 abnormal pup retrieval 0.13558331049604 0.534044845004636 1.4360298336202 0.333333333333333 29.1 29 1 increased airway responsiveness 0.13558331049604 0.534044845004636 1.4360298336202 0.333333333333333 29.1 29 1 arthritis 0.13558331049604 0.534044845004636 1.4360298336202 0.333333333333333 29.1 29 1 delayed intramembranous bone ossification 0.13558331049604 0.534044845004636 1.4360298336202 0.333333333333333 29.1 29 1 dilated ureter 0.13558331049604 0.534044845004636 1.4360298336202 0.333333333333333 29.1 29 1 abnormal glial cell morphology 0.13558331049604 0.534044845004636 1.4360298336202 0.333333333333333 29.1 29 1 abnormal placenta size 0.13558331049604 0.534044845004636 1.4360298336202 0.333333333333333 29.1 29 1 abnormal olfactory nerve morphology 0.13558331049604 0.534044845004636 1.4360298336202 0.333333333333333 29.1 29 1 abnormal cerebral aqueduct morphology 0.13558331049604 0.534044845004636 1.4360298336202 0.333333333333333 29.1 29 1 abnormal Muller cell morphology 0.13558331049604 0.534044845004636 1.4360298336202 0.333333333333333 29.1 29 1 ostium primum atrial septal defect 0.13558331049604 0.534044845004636 1.4360298336202 0.333333333333333 29.1 29 1 decreased trabecular bone mass 0.13558331049604 0.534044845004636 1.4360298336202 0.333333333333333 29.1 29 1 decreased brown adipose tissue mass 0.13558331049604 0.534044845004636 1.4360298336202 0.333333333333333 29.1 29 1 abnormal erythropoiesis 0.000290688546509373 0.00980236524561398 1.43602983362019 0.333333333333333 29.1 29 1 heart right ventricle hypertrophy 0.0278193108229261 0.217415709573959 1.43602983362019 0.333333333333333 29.1 29 1 lowered ear position 0.106100469019108 0.467245285506807 1.43602983362019 0.333333333333333 29.1 29 1 abnormal heart shape 0.106100469019108 0.467245285506807 1.43602983362019 0.333333333333333 29.1 29 1 underdeveloped hair follicles 0.106100469019108 0.467245285506807 1.43602983362019 0.333333333333333 29.1 29 1 delayed kidney development 0.106100469019108 0.467245285506807 1.43602983362019 0.333333333333333 29.1 29 1 abnormal metacarpal bone morphology 0.106100469019108 0.467245285506807 1.43602983362019 0.333333333333333 29.1 29 1 abnormal pregnancy 0.106100469019108 0.467245285506807 1.43602983362019 0.333333333333333 29.1 29 1 abnormal sperm axoneme morphology 0.106100469019108 0.467245285506807 1.43602983362019 0.333333333333333 29.1 29 1 decreased tumor latency 0.106100469019108 0.467245285506807 1.43602983362019 0.333333333333333 29.1 29 1 primary atelectasis 0.106100469019108 0.467245285506807 1.43602983362019 0.333333333333333 29.1 29 1 abnormal hypoglossal nerve topology 0.106100469019108 0.467245285506807 1.43602983362019 0.333333333333333 29.1 29 1 lethality throughout fetal growth and development, complete penetrance 1.80253547987372e-06 0.000142343079561457 1.4284717818643 0.331578947368421 29.1 29 1 weight loss 4.59682440595203e-06 0.000299783789860415 1.42782394885665 0.331428571428571 29.1 29 1 increased anxiety-related response 4.39663711002076e-05 0.00214443819826993 1.42569868373804 0.330935251798561 29.1 29 1 neonatal lethality, incomplete penetrance 3.02415234587925e-08 3.76002744233681e-06 1.42498345028466 0.330769230769231 29.1 29 1 reduced male fertility 2.34214750262204e-07 2.42753829698847e-05 1.42337758839006 0.330396475770925 29.1 29 1 increased grip strength 0.000932660671942493 0.023227383534434 1.420249285998 0.32967032967033 29.1 29 1 teratozoospermia 0.00113199298271614 0.0263803401885244 1.4197113127836 0.329545454545455 29.1 29 1 abnormal visceral yolk sac morphology 0.00202992531706886 0.040815312395225 1.41785224078956 0.329113924050633 29.1 29 1 abnormal nervous system morphology 0.00202992531706886 0.040815312395225 1.41785224078956 0.329113924050633 29.1 29 1 domed cranium 0.00365931196203807 0.0606835900371313 1.41551512171134 0.328571428571429 29.1 29 1 increased total body fat amount 7.83076349799836e-05 0.00354164076386744 1.41459655252139 0.328358208955224 29.1 29 1 decreased compact bone thickness 0.00445980006958607 0.0707266031985899 1.41459655252139 0.328358208955224 29.1 29 1 decreased circulating LDL cholesterol level 0.00543978884595113 0.0764567417563289 1.41359186746988 0.328125 29.1 29 1 decreased caudal vertebrae number 0.00543978884595113 0.0764567417563289 1.41359186746988 0.328125 29.1 29 1 increased sacral vertebrae number 0.00543978884595113 0.0764567417563289 1.41359186746988 0.328125 29.1 29 1 increased osteoclast cell number 0.00664098699273969 0.0882006005058989 1.4124883609379 0.327868852459016 29.1 29 1 embryonic growth arrest 3.46405493779547e-07 3.44673466310649e-05 1.41094634307661 0.327510917030568 29.1 29 1 increased circulating calcium level 0.00992758390354938 0.113801221014189 1.40992020028165 0.327272727272727 29.1 29 1 decreased circulating calcium level 0.00992758390354938 0.113801221014189 1.40992020028165 0.327272727272727 29.1 29 1 abnormal head morphology 0.00992758390354938 0.113801221014189 1.40992020028165 0.327272727272727 29.1 29 1 increased circulating alkaline phosphatase level 1.74371665924609e-05 0.000974718020196551 1.40943668855315 0.327160493827161 29.1 29 1 decreased kidney weight 0.0121590212052798 0.132947539552235 1.40841387528135 0.326923076923077 29.1 29 1 absent kidney 0.0149117929766318 0.149253539270332 1.40672310232182 0.326530612244898 29.1 29 1 abnormal bone structure 3.24824234079314e-06 0.000227605713316139 1.40626755727574 0.326424870466321 29.1 29 1 abnormal forelimb morphology 0.0183150284153628 0.172898038645977 1.40481179375889 0.326086956521739 29.1 29 1 short tail 0.00203725745951836 0.040815312395225 1.40142670509923 0.325301204819277 29.1 29 1 pale yolk sac 0.00203725745951836 0.040815312395225 1.40142670509923 0.325301204819277 29.1 29 1 perinatal lethality 0.0277750707486475 0.217415709573959 1.40012908777969 0.325 29.1 29 1 decreased birth body size 0.000360100919087812 0.0117524001302023 1.39823957484072 0.324561403508772 29.1 29 1 increased brown adipose tissue amount 0.0343123040438285 0.245877232575422 1.39721821649532 0.324324324324324 29.1 29 1 malocclusion 0.0343123040438285 0.245877232575422 1.39721821649532 0.324324324324324 29.1 29 1 abnormal breathing pattern 0.0343123040438285 0.245877232575422 1.39721821649532 0.324324324324324 29.1 29 1 abnormal hair follicle development 0.0343123040438285 0.245877232575422 1.39721821649532 0.324324324324324 29.1 29 1 increased circulating free fatty acid level 0.00446395043303663 0.0707266031985899 1.39557828901118 0.323943661971831 29.1 29 1 kinked tail 0.000774677162633087 0.0210602124814186 1.39379366204313 0.323529411764706 29.1 29 1 pericardial edema 0.00544033901140511 0.0764567417563289 1.39379366204313 0.323529411764706 29.1 29 1 abnormal bone remodeling 0.0424965164777418 0.277090654622235 1.39379366204313 0.323529411764706 29.1 29 1 decreased pancreatic beta cell number 0.0424965164777418 0.277090654622235 1.39379366204313 0.323529411764706 29.1 29 1 hemorrhage 5.09362045353804e-07 4.78127580308523e-05 1.39325447687406 0.323404255319149 29.1 29 1 preweaning lethality, complete penetrance 7.13207614653318e-19 3.94245320322251e-16 1.39139647392659 0.322972972972973 29.1 29 1 abnormal cranial ganglia morphology 0.0527909615719323 0.306729723639636 1.38970629060019 0.32258064516129 29.1 29 1 absent mature ovarian follicles 0.0527909615719323 0.306729723639636 1.38970629060019 0.32258064516129 29.1 29 1 abnormal retinal photoreceptor layer morphology 0.0527909615719323 0.306729723639636 1.38970629060019 0.32258064516129 29.1 29 1 abnormal retinal pigmentation 0.00203472651491189 0.040815312395225 1.38651156349536 0.32183908045977 29.1 29 1 abnormal nervous system physiology 0.000435690505666961 0.0136324545012147 1.3860809698421 0.321739130434783 29.1 29 1 abnormal coat/hair pigmentation 0.000527307538572437 0.0156152083595112 1.38474305384805 0.321428571428571 29.1 29 1 abnormal circulating cholesterol level 0.0658141069268291 0.362597100731977 1.38474305384805 0.321428571428571 29.1 29 1 straub tail 0.0658141069268291 0.362597100731977 1.38474305384805 0.321428571428571 29.1 29 1 premature aging 0.0658141069268291 0.362597100731977 1.38474305384805 0.321428571428571 29.1 29 1 abnormal brainstem morphology 0.0658141069268291 0.362597100731977 1.38474305384805 0.321428571428571 29.1 29 1 subcutaneous edema 0.0658141069268291 0.362597100731977 1.38474305384805 0.321428571428571 29.1 29 1 decreased heart weight 0.00300363255229619 0.0524949777219616 1.38284354348611 0.320987654320988 29.1 29 1 abnormal coat/ hair morphology 0.0148288031456287 0.14917878754438 1.38184002857792 0.320754716981132 29.1 29 1 abnormal mesoderm development 0.0148288031456287 0.14917878754438 1.38184002857792 0.320754716981132 29.1 29 1 atrioventricular septal defect 0.0148288031456287 0.14917878754438 1.38184002857792 0.320754716981132 29.1 29 1 cleft palate 0.000203213481765741 0.00771745856324093 1.38121953462706 0.320610687022901 29.1 29 1 delayed bone ossification 0.0044439093402945 0.0707266031985899 1.37858864027539 0.32 29.1 29 1 decreased heart rate 0.00113475232167723 0.0263803401885244 1.37858864027539 0.32 29.1 29 1 spontaneous skin ulceration 0.0824067662294666 0.422627455994146 1.37858864027539 0.32 29.1 29 1 abnormal energy expenditure 0.0824067662294666 0.422627455994146 1.37858864027539 0.32 29.1 29 1 abnormal lung morphology 0.000434063357808727 0.0136324545012147 1.37569244565296 0.319327731092437 29.1 29 1 cleft secondary palate 0.00166806555067361 0.0354642141649625 1.37492218112572 0.319148936170213 29.1 29 1 increased systemic arterial blood pressure 0.0223318395058305 0.196293464763553 1.37492218112572 0.319148936170213 29.1 29 1 neuron degeneration 0.0223318395058305 0.196293464763553 1.37492218112572 0.319148936170213 29.1 29 1 decreased bone trabecula number 0.0223318395058305 0.196293464763553 1.37492218112572 0.319148936170213 29.1 29 1 increased thermal nociceptive threshold 0.00202361137773267 0.040815312395225 1.3729076431314 0.318681318681319 29.1 29 1 small kidney 0.0024560021632699 0.0464992808763957 1.37075575027382 0.318181818181818 29.1 29 1 increased T cell number 0.0024560021632699 0.0464992808763957 1.37075575027382 0.318181818181818 29.1 29 1 osteoporosis 0.0274705748173568 0.217415709573959 1.37075575027382 0.318181818181818 29.1 29 1 abnormal circadian rhythm 0.0274705748173568 0.217415709573959 1.37075575027382 0.318181818181818 29.1 29 1 abnormal astrocyte morphology 0.0274705748173568 0.217415709573959 1.37075575027382 0.318181818181818 29.1 29 1 intestinal ulcer 0.103739256759606 0.467245285506807 1.37075575027382 0.318181818181818 29.1 29 1 increased body size 0.103739256759606 0.467245285506807 1.37075575027382 0.318181818181818 29.1 29 1 abnormal tail movements 0.103739256759606 0.467245285506807 1.37075575027382 0.318181818181818 29.1 29 1 prolonged PR interval 0.103739256759606 0.467245285506807 1.37075575027382 0.318181818181818 29.1 29 1 abnormal basement membrane morphology 0.103739256759606 0.467245285506807 1.37075575027382 0.318181818181818 29.1 29 1 cleft upper lip 0.103739256759606 0.467245285506807 1.37075575027382 0.318181818181818 29.1 29 1 pulmonary vascular congestion 0.103739256759606 0.467245285506807 1.37075575027382 0.318181818181818 29.1 29 1 rough coat 0.103739256759606 0.467245285506807 1.37075575027382 0.318181818181818 29.1 29 1 embryonic lethality before implantation, incomplete penetrance 0.103739256759606 0.467245285506807 1.37075575027382 0.318181818181818 29.1 29 1 respiratory failure 9.46766503820322e-05 0.00413172224254921 1.36945891418085 0.317880794701987 29.1 29 1 double outlet right ventricle 0.000930695349948684 0.023227383534434 1.36892563578748 0.317757009345794 29.1 29 1 cardiac fibrosis 0.00298216153504017 0.0524249245117486 1.36845195909689 0.317647058823529 29.1 29 1 abnormal hair follicle morphology 0.00980913878504829 0.113226137948063 1.36764746059066 0.317460317460317 29.1 29 1 decreased cardiac muscle contractility 0.00112700425581543 0.0263803401885244 1.36698993777307 0.317307692307692 29.1 29 1 abnormal blood vessel morphology 0.000137866633306538 0.00566848347685973 1.36670425544543 0.317241379310345 29.1 29 1 hemopericardium 0.0338550930279368 0.245877232575422 1.36597959783384 0.317073170731707 29.1 29 1 increased bone trabecula number 0.0338550930279368 0.245877232575422 1.36597959783384 0.317073170731707 29.1 29 1 abnormal eating behavior 0.011981700321679 0.131587106181795 1.36422834193919 0.316666666666667 29.1 29 1 abnormal long bone epiphyseal plate morphology 0.011981700321679 0.131587106181795 1.36422834193919 0.316666666666667 29.1 29 1 abnormal heart development 7.79283217636469e-05 0.00354164076386744 1.36331946229765 0.316455696202532 29.1 29 1 cardiac hypertrophy 0.00165416709464058 0.0354363411605138 1.36276300537427 0.316326530612245 29.1 29 1 abnormal embryo development 0.000242509612566706 0.00864081626415099 1.36211653336033 0.316176470588235 29.1 29 1 abnormal triglyceride level 0.131492280529088 0.534044845004636 1.36044931606124 0.315789473684211 29.1 29 1 stereotypic behavior 0.131492280529088 0.534044845004636 1.36044931606124 0.315789473684211 29.1 29 1 increased malignant tumor incidence 0.131492280529088 0.534044845004636 1.36044931606124 0.315789473684211 29.1 29 1 abnormal ear morphology 0.131492280529088 0.534044845004636 1.36044931606124 0.315789473684211 29.1 29 1 decreased germ cell number 0.131492280529088 0.534044845004636 1.36044931606124 0.315789473684211 29.1 29 1 increased susceptibility to ischemic brain injury 0.131492280529088 0.534044845004636 1.36044931606124 0.315789473684211 29.1 29 1 maternal imprinting 0.131492280529088 0.534044845004636 1.36044931606124 0.315789473684211 29.1 29 1 abnormal optic vesicle formation 0.131492280529088 0.534044845004636 1.36044931606124 0.315789473684211 29.1 29 1 abnormal photoreceptor inner segment morphology 0.131492280529088 0.534044845004636 1.36044931606124 0.315789473684211 29.1 29 1 increased left ventricle weight 0.131492280529088 0.534044845004636 1.36044931606124 0.315789473684211 29.1 29 1 abnormal behavioral response to xenobiotic 0.131492280529088 0.534044845004636 1.36044931606124 0.315789473684211 29.1 29 1 decreased susceptibility to weight gain 0.131492280529088 0.534044845004636 1.36044931606124 0.315789473684211 29.1 29 1 shortened RR interval 0.131492280529088 0.534044845004636 1.36044931606124 0.315789473684211 29.1 29 1 abnormal seminiferous tubule morphology 0.000164930336249187 0.00651213033999767 1.35734326739443 0.315068493150685 29.1 29 1 decreased bone marrow cell number 0.00651721393216801 0.0882006005058989 1.35734326739443 0.315068493150685 29.1 29 1 short snout 0.00111579034881782 0.0263083269448751 1.35625039841907 0.314814814814815 29.1 29 1 impaired glucose tolerance 1.24832167665251e-06 0.000108177146215121 1.35496363333518 0.314516129032258 29.1 29 1 abnormal kidney morphology 4.36985079808663e-05 0.00214443819826993 1.35397098598476 0.314285714285714 29.1 29 1 pallor 4.36985079808663e-05 0.00214443819826993 1.35397098598476 0.314285714285714 29.1 29 1 abnormal gluconeogenesis 0.0219795664233971 0.196293464763553 1.35155749046607 0.313725490196078 29.1 29 1 increased kidney weight 0.0219795664233971 0.196293464763553 1.35155749046607 0.313725490196078 29.1 29 1 cochlear inner hair cell degeneration 0.0219795664233971 0.196293464763553 1.35155749046607 0.313725490196078 29.1 29 1 abnormal trophoblast layer morphology 0.0219795664233971 0.196293464763553 1.35155749046607 0.313725490196078 29.1 29 1 abnormal cell cycle 0.000911067994629148 0.023227383534434 1.34861932200853 0.31304347826087 29.1 29 1 abnormal skeleton morphology 0.000911067994629148 0.023227383534434 1.34861932200853 0.31304347826087 29.1 29 1 abnormal osteoclast physiology 0.0117952069391834 0.130692994482043 1.34627796901893 0.3125 29.1 29 1 polydipsia 0.0642825480336224 0.356131042836605 1.34627796901893 0.3125 29.1 29 1 increased dopamine level 0.0642825480336224 0.356131042836605 1.34627796901893 0.3125 29.1 29 1 abnormal depression-related behavior 0.0642825480336224 0.356131042836605 1.34627796901893 0.3125 29.1 29 1 failure of tooth eruption 0.16818513178791 0.534044845004636 1.34627796901893 0.3125 29.1 29 1 abnormal bone marrow cell number 0.16818513178791 0.534044845004636 1.34627796901893 0.3125 29.1 29 1 vasculature congestion 0.16818513178791 0.534044845004636 1.34627796901893 0.3125 29.1 29 1 decreased mast cell number 0.16818513178791 0.534044845004636 1.34627796901893 0.3125 29.1 29 1 abnormal hair follicle orientation 0.16818513178791 0.534044845004636 1.34627796901893 0.3125 29.1 29 1 abnormal extraembryonic endoderm formation 0.16818513178791 0.534044845004636 1.34627796901893 0.3125 29.1 29 1 white spotting 0.16818513178791 0.534044845004636 1.34627796901893 0.3125 29.1 29 1 abnormal epicardium morphology 0.16818513178791 0.534044845004636 1.34627796901893 0.3125 29.1 29 1 paternal imprinting 0.16818513178791 0.534044845004636 1.34627796901893 0.3125 29.1 29 1 increased pancreatic beta cell number 0.16818513178791 0.534044845004636 1.34627796901893 0.3125 29.1 29 1 decreased aggression towards mice 0.16818513178791 0.534044845004636 1.34627796901893 0.3125 29.1 29 1 small pancreas 0.16818513178791 0.534044845004636 1.34627796901893 0.3125 29.1 29 1 increased cochlear outer hair cell number 0.16818513178791 0.534044845004636 1.34627796901893 0.3125 29.1 29 1 decreased circulating prolactin level 0.16818513178791 0.534044845004636 1.34627796901893 0.3125 29.1 29 1 loose skin 0.16818513178791 0.534044845004636 1.34627796901893 0.3125 29.1 29 1 kidney degeneration 0.16818513178791 0.534044845004636 1.34627796901893 0.3125 29.1 29 1 decreased skeletal muscle weight 0.16818513178791 0.534044845004636 1.34627796901893 0.3125 29.1 29 1 vertebral transformation 0.0269760176194795 0.217415709573959 1.34627796901893 0.3125 29.1 29 1 abnormal phalanx morphology 0.0269760176194795 0.217415709573959 1.34627796901893 0.3125 29.1 29 1 abnormal vertebrae morphology 0.00133222144494049 0.0302639346510454 1.34380773421339 0.311926605504587 29.1 29 1 thin ventricular wall 0.00352458921202555 0.0593206067565011 1.34029451137885 0.311111111111111 29.1 29 1 abnormal ectoderm development 0.0331598472136656 0.245877232575422 1.34029451137885 0.311111111111111 29.1 29 1 albuminuria 0.0331598472136656 0.245877232575422 1.34029451137885 0.311111111111111 29.1 29 1 small placenta 0.0331598472136656 0.245877232575422 1.34029451137885 0.311111111111111 29.1 29 1 cardiomyopathy 0.0331598472136656 0.245877232575422 1.34029451137885 0.311111111111111 29.1 29 1 abnormal angiogenesis 0.00780328527366984 0.098486792483631 1.33900079080802 0.310810810810811 29.1 29 1 abnormal intestine morphology 0.00780328527366984 0.098486792483631 1.33900079080802 0.310810810810811 29.1 29 1 insulin resistance 0.000502299969674012 0.0151451051462316 1.33811870860064 0.310606060606061 29.1 29 1 short limbs 0.00427462345292103 0.069859843503959 1.33699329337053 0.310344827586207 29.1 29 1 cochlear ganglion degeneration 0.017591077253689 0.167654424017439 1.33699329337053 0.310344827586207 29.1 29 1 thrombocytosis 0.017591077253689 0.167654424017439 1.33699329337053 0.310344827586207 29.1 29 1 focal hair loss 0.0800943332890208 0.4135188893344 1.33699329337053 0.310344827586207 29.1 29 1 abnormal spinal nerve morphology 0.0800943332890208 0.4135188893344 1.33699329337053 0.310344827586207 29.1 29 1 increased retinal apoptosis 0.0800943332890208 0.4135188893344 1.33699329337053 0.310344827586207 29.1 29 1 enlarged liver 0.00236005652687524 0.045158773927709 1.33550774526678 0.31 29.1 29 1 abnormal cartilage morphology 0.040832930072112 0.269064671667228 1.3334562740759 0.30952380952381 29.1 29 1 spina bifida 0.040832930072112 0.269064671667228 1.3334562740759 0.30952380952381 29.1 29 1 decreased mean corpuscular hemoglobin 0.0115619229814008 0.128681357567044 1.33043940467753 0.308823529411765 29.1 29 1 decreased total body fat amount 8.30753962562262e-08 8.98478470379837e-06 1.32854257062467 0.308383233532934 29.1 29 1 male infertility 5.59318119547765e-11 1.2648216567046e-08 1.32754249032483 0.308151093439364 29.1 29 1 increased embryonic tissue cell apoptosis 0.00764526170597718 0.0977768045944382 1.3255660002648 0.307692307692308 29.1 29 1 liver hypoplasia 0.0263442531870047 0.217415709573959 1.3255660002648 0.307692307692308 29.1 29 1 abnormal hair growth 0.0263442531870047 0.217415709573959 1.3255660002648 0.307692307692308 29.1 29 1 decreased body temperature 0.0263442531870047 0.217415709573959 1.3255660002648 0.307692307692308 29.1 29 1 abnormal heart looping 0.0503821929367657 0.299822260598576 1.3255660002648 0.307692307692308 29.1 29 1 abnormal xiphoid process morphology 0.10020796407399 0.461067424887745 1.3255660002648 0.307692307692308 29.1 29 1 heart inflammation 0.10020796407399 0.461067424887745 1.3255660002648 0.307692307692308 29.1 29 1 pulmonary edema 0.10020796407399 0.461067424887745 1.3255660002648 0.307692307692308 29.1 29 1 increased thymocyte apoptosis 0.10020796407399 0.461067424887745 1.3255660002648 0.307692307692308 29.1 29 1 cyanosis 4.88752997859993e-05 0.00236072443141113 1.32384000286862 0.307291666666667 29.1 29 1 abnormal suckling behavior 0.00507958697456987 0.0747661100546896 1.32180018776404 0.306818181818182 29.1 29 1 spleen hyperplasia 0.00928916309035504 0.10873785029298 1.32114744693058 0.306666666666667 29.1 29 1 embryonic lethality between implantation and somite formation, complete penetrance 5.95230153326353e-06 0.000374844305417545 1.31880290842671 0.306122448979592 29.1 29 1 prenatal lethality, complete penetrance 1.57391916054839e-06 0.000126294319737552 1.31722160997536 0.305755395683453 29.1 29 1 decreased erythrocyte cell number 0.000266909906266935 0.00915777092191727 1.31712290472171 0.305732484076433 29.1 29 1 abnormal uterus morphology 0.062307485473387 0.350259593480339 1.31636068081851 0.305555555555556 29.1 29 1 abnormal lysosome morphology 0.062307485473387 0.350259593480339 1.31636068081851 0.305555555555556 29.1 29 1 head tilt 0.062307485473387 0.350259593480339 1.31636068081851 0.305555555555556 29.1 29 1 increased or absent threshold for auditory brainstem response 1.26116069959337e-06 0.000108177146215121 1.31180579957001 0.304498269896194 29.1 29 1 abnormal sacral vertebrae morphology 0.126008704052811 0.531084438278263 1.31115767417496 0.304347826086957 29.1 29 1 abnormal lens development 0.126008704052811 0.531084438278263 1.31115767417496 0.304347826086957 29.1 29 1 decreased spleen weight 0.0137362144640683 0.142528790402004 1.31115767417496 0.304347826086957 29.1 29 1 short mandible 0.0256153222685916 0.214556255890999 1.30781288418982 0.303571428571429 29.1 29 1 impaired swimming 0.0167189830203708 0.161195621175087 1.30548166692745 0.303030303030303 29.1 29 1 abnormal epidermis stratum basale morphology 0.0772606538386626 0.403751841226204 1.30548166692745 0.303030303030303 29.1 29 1 dilated heart atrium 0.0772606538386626 0.403751841226204 1.30548166692745 0.303030303030303 29.1 29 1 cardiovascular system phenotype 0.0772606538386626 0.403751841226204 1.30548166692745 0.303030303030303 29.1 29 1 neonatal lethality, complete penetrance 2.29115757080868e-09 4.05900339056907e-07 1.30376392789202 0.302631578947368 29.1 29 1 abnormal male reproductive system morphology 0.0487629755856056 0.294205632250759 1.30244566305087 0.302325581395349 29.1 29 1 kidney failure 0.0487629755856056 0.294205632250759 1.30244566305087 0.302325581395349 29.1 29 1 abnormal eye morphology 0.000809796847247286 0.0215440605083168 1.30172488515212 0.302158273381295 29.1 29 1 extramedullary hematopoiesis 0.00322627907246597 0.0555388871471217 1.30055532101452 0.30188679245283 29.1 29 1 enlarged kidney 0.0313239072589512 0.24160688157098 1.30055532101452 0.30188679245283 29.1 29 1 decreased percent body fat/body weight 0.0133526356594687 0.142528790402004 1.29832834272511 0.301369863013699 29.1 29 1 respiratory distress 0.000243158648639425 0.00864081626415099 1.29491707540318 0.300578034682081 29.1 29 1 increased sensitivity to xenobiotic induced morbidity/mortality 0.00313926095768949 0.0544175026637813 1.29242685025818 0.3 29.1 29 1 embryonic lethality during organogenesis, complete penetrance 9.29935526217589e-11 1.92767885122188e-08 1.29242685025818 0.3 29.1 29 1 intracranial hemorrhage 0.0248197163836847 0.211073656425353 1.29242685025818 0.3 29.1 29 1 decreased oocyte number 0.0383473833925849 0.259562220922599 1.29242685025818 0.3 29.1 29 1 decreased respiratory quotient 0.0383473833925849 0.259562220922599 1.29242685025818 0.3 29.1 29 1 impaired ovarian folliculogenesis 0.0600709595888164 0.339220231503248 1.29242685025818 0.3 29.1 29 1 abnormal heart tube morphology 0.0961015603265615 0.44682734824733 1.29242685025818 0.3 29.1 29 1 abnormal microglial cell physiology 0.0961015603265615 0.44682734824733 1.29242685025818 0.3 29.1 29 1 abnormal fat pad morphology 0.0961015603265615 0.44682734824733 1.29242685025818 0.3 29.1 29 1 abnormal basioccipital bone morphology 0.159463018941751 0.534044845004636 1.29242685025818 0.3 29.1 29 1 abnormal pericardium morphology 0.159463018941751 0.534044845004636 1.29242685025818 0.3 29.1 29 1 small gonad 0.159463018941751 0.534044845004636 1.29242685025818 0.3 29.1 29 1 increased urine glucose level 0.159463018941751 0.534044845004636 1.29242685025818 0.3 29.1 29 1 abnormal hair texture 0.159463018941751 0.534044845004636 1.29242685025818 0.3 29.1 29 1 abnormal fibula morphology 0.159463018941751 0.534044845004636 1.29242685025818 0.3 29.1 29 1 abnormal response to tactile stimuli 0.159463018941751 0.534044845004636 1.29242685025818 0.3 29.1 29 1 abnormal neuron proliferation 0.159463018941751 0.534044845004636 1.29242685025818 0.3 29.1 29 1 increased tumor incidence 0.00204281664048463 0.040815312395225 1.28547831880517 0.298387096774194 29.1 29 1 abnormal circulating amino acid level 0.0302754472286314 0.2357125977503 1.28486879850228 0.298245614035088 29.1 29 1 embryonic lethality, complete penetrance 1.45052405483553e-06 0.000120272619546779 1.28297336232525 0.297805642633229 29.1 29 1 cataract 0.00245815293879237 0.0464992808763957 1.28174563661968 0.297520661157025 29.1 29 1 decreased circulating chloride level 0.0741516006935849 0.390788361706128 1.28078336512071 0.297297297297297 29.1 29 1 abnormal pancreatic beta cell physiology 0.0741516006935849 0.390788361706128 1.28078336512071 0.297297297297297 29.1 29 1 polyphagia 0.0369620095038453 0.254337478951079 1.27647096321795 0.296296296296296 29.1 29 1 abnormal neuronal precursor proliferation 0.0369620095038453 0.254337478951079 1.27647096321795 0.296296296296296 29.1 29 1 thin epidermis 0.119980592991694 0.513244583090007 1.27647096321795 0.296296296296296 29.1 29 1 abnormal eye muscle morphology 0.119980592991694 0.513244583090007 1.27647096321795 0.296296296296296 29.1 29 1 decreased circulating fructosamine level 0.119980592991694 0.513244583090007 1.27647096321795 0.296296296296296 29.1 29 1 hyperglycemia 0.0100108600462393 0.114229423692753 1.27284462525426 0.295454545454545 29.1 29 1 short femur 0.0100108600462393 0.114229423692753 1.27284462525426 0.295454545454545 29.1 29 1 increased inflammatory response 0.00801279495944791 0.0986724131763697 1.26975269499049 0.294736842105263 29.1 29 1 abnormal neuron differentiation 0.00428286477762964 0.069859843503959 1.26934779936071 0.294642857142857 29.1 29 1 abnormal extraembryonic tissue morphology 0.00642214775552849 0.0882006005058989 1.26708514731194 0.294117647058824 29.1 29 1 overexpanded pulmonary alveoli 0.0917457110723797 0.434464449371345 1.26708514731194 0.294117647058824 29.1 29 1 abnormal endoderm development 0.0917457110723797 0.434464449371345 1.26708514731194 0.294117647058824 29.1 29 1 decreased regulatory T cell number 0.0917457110723797 0.434464449371345 1.26708514731194 0.294117647058824 29.1 29 1 increased susceptibility to weight gain 0.0917457110723797 0.434464449371345 1.26708514731194 0.294117647058824 29.1 29 1 abnormal bone marrow cavity morphology 0.203467555821367 0.567723550314808 1.26708514731194 0.294117647058824 29.1 29 1 abnormal duodenum morphology 0.203467555821367 0.567723550314808 1.26708514731194 0.294117647058824 29.1 29 1 abnormal testis development 0.203467555821367 0.567723550314808 1.26708514731194 0.294117647058824 29.1 29 1 abnormal embryonic-extraembryonic boundary morphology 0.203467555821367 0.567723550314808 1.26708514731194 0.294117647058824 29.1 29 1 increased regulatory T cell number 0.203467555821367 0.567723550314808 1.26708514731194 0.294117647058824 29.1 29 1 abnormal ectoplacental cone morphology 0.203467555821367 0.567723550314808 1.26708514731194 0.294117647058824 29.1 29 1 abnormal melanosome morphology 0.203467555821367 0.567723550314808 1.26708514731194 0.294117647058824 29.1 29 1 decreased growth hormone level 0.203467555821367 0.567723550314808 1.26708514731194 0.294117647058824 29.1 29 1 increased brain size 0.203467555821367 0.567723550314808 1.26708514731194 0.294117647058824 29.1 29 1 abnormal ductus venosus valve morphology 0.203467555821367 0.567723550314808 1.26708514731194 0.294117647058824 29.1 29 1 anemia 0.000134568083525057 0.00557896846280965 1.26588411873629 0.293838862559242 29.1 29 1 abnormal spermatogenesis 0.000361430596969036 0.0117524001302023 1.264330614383 0.293478260869565 29.1 29 1 dermatitis 0.0355348201450711 0.245877232575422 1.26271588818327 0.293103448275862 29.1 29 1 abnormal mammary gland development 0.0709189043726286 0.376483736576994 1.26090424415432 0.292682926829268 29.1 29 1 Leydig cell hyperplasia 0.0709189043726286 0.376483736576994 1.26090424415432 0.292682926829268 29.1 29 1 anophthalmia 0.0116631539617775 0.129518283392507 1.25854300025141 0.292134831460674 29.1 29 1 perinatal lethality, incomplete penetrance 0.000102287286407767 0.00442503695546643 1.25811463299468 0.292035398230089 29.1 29 1 decreased cell proliferation 0.000418063898496585 0.0133324865065417 1.25749639484579 0.291891891891892 29.1 29 1 decreased litter size 1.66818064605211e-05 0.000943090762966958 1.25716490772444 0.291814946619217 29.1 29 1 ocular hypertelorism 0.150464225522495 0.534044845004636 1.25652610441767 0.291666666666667 29.1 29 1 hemolytic anemia 0.150464225522495 0.534044845004636 1.25652610441767 0.291666666666667 29.1 29 1 decreased ovulation rate 0.150464225522495 0.534044845004636 1.25652610441767 0.291666666666667 29.1 29 1 abnormal retinal ganglion layer morphology 0.150464225522495 0.534044845004636 1.25652610441767 0.291666666666667 29.1 29 1 abnormal inner cell mass apoptosis 0.150464225522495 0.534044845004636 1.25652610441767 0.291666666666667 29.1 29 1 abnormal neuromuscular synapse morphology 0.0222400215608751 0.196293464763553 1.25652610441767 0.291666666666667 29.1 29 1 abnormal somite development 0.0176708005625837 0.168092223324768 1.25425390531384 0.291139240506329 29.1 29 1 perinatal lethality, complete penetrance 0.000179668771564413 0.00692908634521669 1.25399788287961 0.291079812206573 29.1 29 1 abnormal joint morphology 0.0432992564026679 0.280486719535511 1.25326240025035 0.290909090909091 29.1 29 1 decreased embryo size 3.19728094337524e-08 3.78725540316472e-06 1.25277079627536 0.290794979079498 29.1 29 1 decreased hemoglobin content 0.0020830200895224 0.0412869519736013 1.25270687613677 0.290780141843972 29.1 29 1 abnormal liver morphology 0.000596759321918707 0.0168686228780998 1.25151203376956 0.290502793296089 29.1 29 1 abnormal postnatal growth/weight/body size 0.113819532544364 0.492393195137576 1.25073566154017 0.290322580645161 29.1 29 1 abnormal nose morphology 0.113819532544364 0.492393195137576 1.25073566154017 0.290322580645161 29.1 29 1 inner cell mass degeneration 0.113819532544364 0.492393195137576 1.25073566154017 0.290322580645161 29.1 29 1 abnormal CD8-positive, alpha beta T cell morphology 0.113819532544364 0.492393195137576 1.25073566154017 0.290322580645161 29.1 29 1 abnormal mitochondrial ATP synthesis coupled electron transport 0.113819532544364 0.492393195137576 1.25073566154017 0.290322580645161 29.1 29 1 abnormal neural tube morphology 0.00109271049207563 0.0260106923352932 1.24987781815091 0.290123456790123 29.1 29 1 thrombocytopenia 0.00200923350735598 0.040815312395225 1.24786040714582 0.289655172413793 29.1 29 1 decreased total retina thickness 0.0873266026471291 0.432718972280346 1.2470785397228 0.289473684210526 29.1 29 1 abnormal ovarian follicle morphology 0.0676582529881435 0.369889899578037 1.2445591891375 0.288888888888889 29.1 29 1 distended pericardium 0.0527982749443713 0.306729723639636 1.24271812524825 0.288461538461538 29.1 29 1 abnormal snout morphology 0.0527982749443713 0.306729723639636 1.24271812524825 0.288461538461538 29.1 29 1 absent corpus luteum 0.0527982749443713 0.306729723639636 1.24271812524825 0.288461538461538 29.1 29 1 abnormal pulmonary alveolus morphology 0.0103736614179916 0.1179056141975 1.23697619331641 0.287128712871287 29.1 29 1 abnormal vitelline vasculature morphology 0.0066461182214698 0.0882006005058989 1.23623437850782 0.28695652173913 29.1 29 1 abnormal enzyme/coenzyme activity 0.00179501945724008 0.0378399228803788 1.2348027231766 0.286624203821656 29.1 29 1 increased body weight 0.000253504900489852 0.00881948867088822 1.2308827145316 0.285714285714286 29.1 29 1 abnormal cardiovascular system physiology 0.00411292113381866 0.0675306357780457 1.2308827145316 0.285714285714286 29.1 29 1 polydactyly 0.0124615037723518 0.135956099270725 1.2308827145316 0.285714285714286 29.1 29 1 hydronephrosis 0.0196336254464779 0.18360392217336 1.2308827145316 0.285714285714286 29.1 29 1 embryonic lethality between somite formation and embryo turning, complete penetrance 0.0312340763402089 0.241288089739968 1.2308827145316 0.285714285714286 29.1 29 1 decreased susceptibility to hepatic steatosis 0.0395840891906128 0.264229720013709 1.2308827145316 0.285714285714286 29.1 29 1 thick pulmonary interalveolar septum 0.107736222658144 0.472235865836358 1.2308827145316 0.285714285714286 29.1 29 1 abnormal dermal layer morphology 0.107736222658144 0.472235865836358 1.2308827145316 0.285714285714286 29.1 29 1 abnormal midbrain development 0.107736222658144 0.472235865836358 1.2308827145316 0.285714285714286 29.1 29 1 enhanced coordination 0.14164718741764 0.534044845004636 1.2308827145316 0.285714285714286 29.1 29 1 increased bone resorption 0.14164718741764 0.534044845004636 1.2308827145316 0.285714285714286 29.1 29 1 increased triglyceride level 0.14164718741764 0.534044845004636 1.2308827145316 0.285714285714286 29.1 29 1 abnormal renal tubule epithelium morphology 0.14164718741764 0.534044845004636 1.2308827145316 0.285714285714286 29.1 29 1 increased vasoconstriction 0.189733852289952 0.536016987588024 1.2308827145316 0.285714285714286 29.1 29 1 hypoalgesia 0.189733852289952 0.536016987588024 1.2308827145316 0.285714285714286 29.1 29 1 decreased cochlear outer hair cell number 0.189733852289952 0.536016987588024 1.2308827145316 0.285714285714286 29.1 29 1 complete atrioventricular septal defect 0.189733852289952 0.536016987588024 1.2308827145316 0.285714285714286 29.1 29 1 embryonic lethality at implantation, complete penetrance 0.189733852289952 0.536016987588024 1.2308827145316 0.285714285714286 29.1 29 1 increased muscle cell glucose uptake 0.189733852289952 0.536016987588024 1.2308827145316 0.285714285714286 29.1 29 1 lethality throughout fetal growth and development, incomplete penetrance 0.00108028939103621 0.0259342885521584 1.2274444946586 0.284916201117318 29.1 29 1 no abnormal phenotype detected 8.91937432296901e-24 1.04642502808848e-20 1.22662605961103 0.284726224783862 29.1 29 1 enlarged heart 0.000234711085021958 0.0085232675035346 1.22557718558965 0.28448275862069 29.1 29 1 abnormal T cell activation 0.0298424247600339 0.23270542818365 1.22256593943341 0.283783783783784 29.1 29 1 internal hemorrhage 0.0377746905334392 0.259562220922599 1.22169702263211 0.283582089552239 29.1 29 1 muscular ventricular septal defect 0.0479979557138515 0.294205632250759 1.22062535857717 0.283333333333333 29.1 29 1 decreased circulating serum albumin level 0.0143247056254498 0.147547433719695 1.21844955579895 0.282828282828283 29.1 29 1 abnormal sleep pattern 0.0786900520230788 0.410692864010257 1.21750355459104 0.282608695652174 29.1 29 1 impaired macrophage chemotaxis 0.101840477890486 0.463122831357558 1.2151021669094 0.282051282051282 29.1 29 1 abnormal ovary morphology 0.0360133074967619 0.248496816638544 1.21354633827059 0.28169014084507 29.1 29 1 decreased liver weight 0.0360133074967619 0.248496816638544 1.21354633827059 0.28169014084507 29.1 29 1 decreased circulating HDL cholesterol level 0.00672138456014362 0.0884626671606204 1.21165017211704 0.28125 29.1 29 1 abnormal craniofacial bone morphology 0.058215711159778 0.329491653037424 1.20928828094332 0.280701754385965 29.1 29 1 abnormal response/metabolism to endogenous compounds 0.0271709575020798 0.217415709573959 1.20836656731455 0.280487804878049 29.1 29 1 abnormal limb morphology 0.0343071426692154 0.245877232575422 1.20626506024096 0.28 29.1 29 1 abnormal interventricular septum morphology 0.0745741509435668 0.392184356177848 1.20626506024096 0.28 29.1 29 1 increased circulating chloride level 0.0745741509435668 0.392184356177848 1.20626506024096 0.28 29.1 29 1 abnormal primitive streak morphology 0.176931015247561 0.534044845004636 1.20626506024096 0.28 29.1 29 1 abnormal keratinocyte physiology 0.176931015247561 0.534044845004636 1.20626506024096 0.28 29.1 29 1 abnormal vertebrae development 0.176931015247561 0.534044845004636 1.20626506024096 0.28 29.1 29 1 impaired conditioned place preference behavior 0.176931015247561 0.534044845004636 1.20626506024096 0.28 29.1 29 1 cachexia 0.0156589502076577 0.152751524084504 1.20129418773997 0.278846153846154 29.1 29 1 increased double-negative T cell number 0.0552676001916067 0.318605227060537 1.20061510679721 0.278688524590164 29.1 29 1 decreased food intake 0.0326608185555538 0.245877232575422 1.19972112682194 0.278481012658228 29.1 29 1 abnormal small intestine morphology 0.0706261488487508 0.376483736576994 1.19669152801683 0.277777777777778 29.1 29 1 enlarged spleen 0.000131986834514987 0.00551793698917698 1.19669152801683 0.277777777777778 29.1 29 1 abnormal digit morphology 0.0413107251644108 0.270422181174926 1.19669152801683 0.277777777777778 29.1 29 1 abnormal heart left ventricle morphology 0.0413107251644108 0.270422181174926 1.19669152801683 0.277777777777778 29.1 29 1 renal hypoplasia 0.125208813883051 0.531084438278263 1.19669152801683 0.277777777777778 29.1 29 1 abnormal trophoblast giant cell morphology 0.125208813883051 0.531084438278263 1.19669152801683 0.277777777777778 29.1 29 1 narrow eye opening 0.125208813883051 0.531084438278263 1.19669152801683 0.277777777777778 29.1 29 1 abnormal megakaryocyte differentiation 0.240916435360698 0.621015163688847 1.19669152801683 0.277777777777778 29.1 29 1 right pulmonary isomerism 0.240916435360698 0.621015163688847 1.19669152801683 0.277777777777778 29.1 29 1 absent spleen 0.240916435360698 0.621015163688847 1.19669152801683 0.277777777777778 29.1 29 1 abnormal retinal rod cell morphology 0.240916435360698 0.621015163688847 1.19669152801683 0.277777777777778 29.1 29 1 absent ureter 0.240916435360698 0.621015163688847 1.19669152801683 0.277777777777778 29.1 29 1 decreased heart rate variability 0.240916435360698 0.621015163688847 1.19669152801683 0.277777777777778 29.1 29 1 long tibia 0.240916435360698 0.621015163688847 1.19669152801683 0.277777777777778 29.1 29 1 abnormal anterior eye segment morphology 0.240916435360698 0.621015163688847 1.19669152801683 0.277777777777778 29.1 29 1 pulmonary hypoplasia 0.0908055197908068 0.434464449371345 1.19159922364229 0.276595744680851 29.1 29 1 aphagia 0.165095893752352 0.534044845004636 1.18843848299602 0.275862068965517 29.1 29 1 increased mortality induced by gamma-irradiation 0.165095893752352 0.534044845004636 1.18843848299602 0.275862068965517 29.1 29 1 enlarged epididymis 0.165095893752352 0.534044845004636 1.18843848299602 0.275862068965517 29.1 29 1 decreased bone strength 0.165095893752352 0.534044845004636 1.18843848299602 0.275862068965517 29.1 29 1 blood in lymph vessels 0.165095893752352 0.534044845004636 1.18843848299602 0.275862068965517 29.1 29 1 increased circulating insulin level 0.00467827469050137 0.0722807968485849 1.18472461273666 0.275 29.1 29 1 decreased circulating phosphate level 0.117684088280774 0.506469151554371 1.18472461273666 0.275 29.1 29 1 abnormal female reproductive system morphology 0.117684088280774 0.506469151554371 1.18472461273666 0.275 29.1 29 1 abnormal skin pigmentation 0.117684088280774 0.506469151554371 1.18472461273666 0.275 29.1 29 1 increased susceptibility to weight loss 0.117684088280774 0.506469151554371 1.18472461273666 0.275 29.1 29 1 abnormal glucose homeostasis 0.00277310580086292 0.0501680049428837 1.183541071665 0.274725274725275 29.1 29 1 female infertility 0.00037186555413063 0.0120131891675317 1.18229523895798 0.274436090225564 29.1 29 1 increased bone mineral density 0.0161759237555149 0.157485754762596 1.18186526129804 0.274336283185841 29.1 29 1 embryonic lethality during organogenesis, incomplete penetrance 0.000943009543701412 0.023227383534434 1.18004190675746 0.273913043478261 29.1 29 1 alopecia 0.026709332659234 0.217415709573959 1.17905607391974 0.273684210526316 29.1 29 1 abnormal bone mineralization 0.0146551263358747 0.148739714423279 1.17493350023471 0.272727272727273 29.1 29 1 obese 0.0446949984547846 0.288401578874907 1.17493350023471 0.272727272727273 29.1 29 1 polyuria 0.0446949984547846 0.288401578874907 1.17493350023471 0.272727272727273 29.1 29 1 abnormal platelet physiology 0.0808737335160319 0.416508099629667 1.17493350023471 0.272727272727273 29.1 29 1 hypertension 0.110624334553177 0.481501368680716 1.17493350023471 0.272727272727273 29.1 29 1 abnormal gametogenesis 0.110624334553177 0.481501368680716 1.17493350023471 0.272727272727273 29.1 29 1 renal interstitial fibrosis 0.110624334553177 0.481501368680716 1.17493350023471 0.272727272727273 29.1 29 1 cochlear hair cell degeneration 0.110624334553177 0.481501368680716 1.17493350023471 0.272727272727273 29.1 29 1 abnormal amino acid level 0.110624334553177 0.481501368680716 1.17493350023471 0.272727272727273 29.1 29 1 abnormal facial nerve morphology 0.221981825613832 0.606124908028986 1.17493350023471 0.272727272727273 29.1 29 1 abnormal germ layer development 0.221981825613832 0.606124908028986 1.17493350023471 0.272727272727273 29.1 29 1 testis hypoplasia 0.221981825613832 0.606124908028986 1.17493350023471 0.272727272727273 29.1 29 1 increased coping response 0.221981825613832 0.606124908028986 1.17493350023471 0.272727272727273 29.1 29 1 aphakia 0.221981825613832 0.606124908028986 1.17493350023471 0.272727272727273 29.1 29 1 abnormal lysosome physiology 0.221981825613832 0.606124908028986 1.17493350023471 0.272727272727273 29.1 29 1 abnormal temporal bone morphology 0.221981825613832 0.606124908028986 1.17493350023471 0.272727272727273 29.1 29 1 increased circulating creatine kinase level 0.221981825613832 0.606124908028986 1.17493350023471 0.272727272727273 29.1 29 1 increased bone volume 0.221981825613832 0.606124908028986 1.17493350023471 0.272727272727273 29.1 29 1 abnormal skin morphology 0.0598583080154355 0.3384035027009 1.1749335002347 0.272727272727273 29.1 29 1 abnormal tooth development 0.154182163507717 0.534044845004636 1.1749335002347 0.272727272727273 29.1 29 1 absent vibrissae 0.154182163507717 0.534044845004636 1.1749335002347 0.272727272727273 29.1 29 1 increased osteoblast cell number 0.154182163507717 0.534044845004636 1.1749335002347 0.272727272727273 29.1 29 1 myeloid hyperplasia 0.154182163507717 0.534044845004636 1.1749335002347 0.272727272727273 29.1 29 1 embryonic lethality before implantation, complete penetrance 0.0139446923842988 0.144230446178559 1.17180034423408 0.272 29.1 29 1 abnormal thoracic vertebrae morphology 0.0763166134554643 0.400501215127569 1.1682954578605 0.271186440677966 29.1 29 1 increased hemoglobin content 0.0763166134554643 0.400501215127569 1.1682954578605 0.271186440677966 29.1 29 1 abnormal osteoclast morphology 0.10401184406712 0.467245285506807 1.16677423981641 0.270833333333333 29.1 29 1 circling 0.0401375056581768 0.265184715337888 1.16571833552698 0.270588235294118 29.1 29 1 abnormal branching of the mammary ductal tree 0.144118892842112 0.534044845004636 1.1643485137461 0.27027027027027 29.1 29 1 abnormal chromosome morphology 0.144118892842112 0.534044845004636 1.1643485137461 0.27027027027027 29.1 29 1 abnormal humerus morphology 0.144118892842112 0.534044845004636 1.1643485137461 0.27027027027027 29.1 29 1 skin lesions 0.0720195465980596 0.381167281197177 1.16250034150206 0.26984126984127 29.1 29 1 decreased rib number 0.0380302785525129 0.259562220922599 1.16173200023207 0.269662921348315 29.1 29 1 hydroencephaly 0.0206552852187594 0.191359485965229 1.16131108284068 0.269565217391304 29.1 29 1 abnormal skin condition 0.0978231452992169 0.454407234233057 1.1598702502317 0.269230769230769 29.1 29 1 abnormal nasal bone morphology 0.205197402522034 0.569992784783429 1.1598702502317 0.269230769230769 29.1 29 1 abnormal leukocyte cell number 0.205197402522034 0.569992784783429 1.1598702502317 0.269230769230769 29.1 29 1 abnormal Schwann cell morphology 0.205197402522034 0.569992784783429 1.1598702502317 0.269230769230769 29.1 29 1 abnormal Mullerian duct morphology 0.205197402522034 0.569992784783429 1.1598702502317 0.269230769230769 29.1 29 1 decreased bone resorption 0.205197402522034 0.569992784783429 1.1598702502317 0.269230769230769 29.1 29 1 decreased Peyer's patch number 0.205197402522034 0.569992784783429 1.1598702502317 0.269230769230769 29.1 29 1 decreased circulating glucose level 0.000603615453900196 0.0169660275884377 1.15808857550016 0.268817204301075 29.1 29 1 decreased circulating cholesterol level 0.00523173759460207 0.0762530411445081 1.15353216143262 0.26775956284153 29.1 29 1 increased circulating cholesterol level 0.00647091547943052 0.0882006005058989 1.15045571897982 0.267045454545455 29.1 29 1 oxidative stress 0.042887100439552 0.278179041312609 1.14882386689616 0.266666666666667 29.1 29 1 delayed eyelid opening 0.190184742270821 0.53607314039509 1.14882386689616 0.266666666666667 29.1 29 1 emphysema 0.190184742270821 0.53607314039509 1.14882386689616 0.266666666666667 29.1 29 1 liver hemorrhage 0.190184742270821 0.53607314039509 1.14882386689616 0.266666666666667 29.1 29 1 abnormal cellular respiration 0.190184742270821 0.53607314039509 1.14882386689616 0.266666666666667 29.1 29 1 spleen hypoplasia 0.0306403728493369 0.238181023321018 1.14882386689616 0.266666666666667 29.1 29 1 increased heart weight 0.0151239314324203 0.149253539270332 1.14675763691972 0.266187050359712 29.1 29 1 abnormal placenta labyrinth morphology 0.0571859258912505 0.329202442727163 1.14518834833003 0.265822784810127 29.1 29 1 abnormal lens morphology 0.0198241777285073 0.185038056659144 1.14433627366609 0.265625 29.1 29 1 abnormal tooth morphology 0.0815430919193855 0.419521077868607 1.14433627366609 0.265625 29.1 29 1 improved glucose tolerance 0.00502978731470164 0.0742527949277171 1.14296252063648 0.26530612244898 29.1 29 1 abnormal respiratory system physiology 0.118305050858559 0.507823665247048 1.14296252063648 0.26530612244898 29.1 29 1 decreased urine osmolality 0.118305050858559 0.507823665247048 1.14296252063648 0.26530612244898 29.1 29 1 increased fluid intake 0.118305050858559 0.507823665247048 1.14296252063648 0.26530612244898 29.1 29 1 enlarged liver sinusoidal spaces 0.176659286384438 0.534044845004636 1.14037663258074 0.264705882352941 29.1 29 1 thin skin 0.176659286384438 0.534044845004636 1.14037663258074 0.264705882352941 29.1 29 1 abnormal nervous system development 0.176659286384438 0.534044845004636 1.14037663258074 0.264705882352941 29.1 29 1 abnormal direction of heart looping 0.176659286384438 0.534044845004636 1.14037663258074 0.264705882352941 29.1 29 1 decreased osteoblast cell number 0.176659286384438 0.534044845004636 1.14037663258074 0.264705882352941 29.1 29 1 abnormal eye electrophysiology 0.0246916555827361 0.210344155007041 1.13932945477305 0.264462809917355 29.1 29 1 abnormal inflammatory response 0.0723475730323688 0.382090420208105 1.13685695161599 0.263888888888889 29.1 29 1 cochlear outer hair cell degeneration 0.0723475730323688 0.382090420208105 1.13685695161599 0.263888888888889 29.1 29 1 abnormal B cell differentiation 0.0481834637239535 0.294205632250759 1.1361994287984 0.263736263736264 29.1 29 1 abnormal frontal bone morphology 0.164401853626035 0.534044845004636 1.13370776338436 0.263157894736842 29.1 29 1 persistence of hyaloid vascular system 0.164401853626035 0.534044845004636 1.13370776338436 0.263157894736842 29.1 29 1 abnormal compact bone morphology 0.164401853626035 0.534044845004636 1.13370776338436 0.263157894736842 29.1 29 1 irregular coat pigmentation 0.279996490657702 0.704237887271014 1.13370776338436 0.263157894736842 29.1 29 1 flaky skin 0.279996490657702 0.704237887271014 1.13370776338436 0.263157894736842 29.1 29 1 abnormal neural crest cell migration 0.279996490657702 0.704237887271014 1.13370776338436 0.263157894736842 29.1 29 1 abnormal digestive system development 0.279996490657702 0.704237887271014 1.13370776338436 0.263157894736842 29.1 29 1 increased liver adenoma incidence 0.279996490657702 0.704237887271014 1.13370776338436 0.263157894736842 29.1 29 1 increased liver cholesterol level 0.279996490657702 0.704237887271014 1.13370776338436 0.263157894736842 29.1 29 1 abnormal facial morphology 0.104110061162471 0.467245285506807 1.13370776338436 0.263157894736842 29.1 29 1 increased circulating triglyceride level 0.0178877706217551 0.169831410006168 1.12901655884622 0.262068965517241 29.1 29 1 abnormal optic nerve morphology 0.153239654998606 0.534044845004636 1.1283091549873 0.261904761904762 29.1 29 1 skin edema 0.153239654998606 0.534044845004636 1.1283091549873 0.261904761904762 29.1 29 1 increased T cell proliferation 0.0384374274840519 0.259818208876574 1.12735052358969 0.261682242990654 29.1 29 1 edema 0.0110905806480335 0.124831761818929 1.12711643917864 0.261627906976744 29.1 29 1 decreased monocyte cell number 0.091850796849567 0.434464449371345 1.12673110022508 0.261538461538462 29.1 29 1 fragile skeleton 0.255854692047133 0.654772167147369 1.12384943500711 0.260869565217391 29.1 29 1 abnormal cranial nerve morphology 0.255854692047133 0.654772167147369 1.12384943500711 0.260869565217391 29.1 29 1 hypotension 0.255854692047133 0.654772167147369 1.12384943500711 0.260869565217391 29.1 29 1 failure of embryo implantation 0.255854692047133 0.654772167147369 1.12384943500711 0.260869565217391 29.1 29 1 abnormal basicranium morphology 0.255854692047133 0.654772167147369 1.12384943500711 0.260869565217391 29.1 29 1 abnormal hematopoietic stem cell physiology 0.255854692047133 0.654772167147369 1.12384943500711 0.260869565217391 29.1 29 1 abnormal vertebral artery topology 0.255854692047133 0.654772167147369 1.12384943500711 0.260869565217391 29.1 29 1 increased body length 0.133669961639501 0.534044845004636 1.12010327022375 0.26 29.1 29 1 diluted coat color 0.125053888017766 0.531084438278263 1.11691209281571 0.259259259259259 29.1 29 1 decreased platelet aggregation 0.125053888017766 0.531084438278263 1.11691209281571 0.259259259259259 29.1 29 1 abnormal trigeminal ganglion morphology 0.235023285857654 0.618967091720245 1.11691209281571 0.259259259259259 29.1 29 1 cryptorchism 0.235023285857654 0.618967091720245 1.11691209281571 0.259259259259259 29.1 29 1 increased insulin sensitivity 0.0233278551367261 0.199067031398306 1.11468050022267 0.258741258741259 29.1 29 1 abnormal embryonic neuroepithelium morphology 0.117105646244513 0.505729678877128 1.11416107780877 0.258620689655172 29.1 29 1 abnormal enzyme/coenzyme level 0.117105646244513 0.505729678877128 1.11416107780877 0.258620689655172 29.1 29 1 abnormal embryonic tissue morphology 0.0220836800941673 0.196293464763553 1.11365578933811 0.258503401360544 29.1 29 1 prenatal lethality 0.109757257402652 0.479826323003685 1.11176503248015 0.258064516129032 29.1 29 1 decreased thymus weight 0.216746554349589 0.598734938955937 1.11176503248015 0.258064516129032 29.1 29 1 abnormal retina morphology 0.00845013993885671 0.100814019654226 1.10779444307844 0.257142857142857 29.1 29 1 increased carcinoma incidence 0.200517269982001 0.562647161963033 1.10779444307844 0.257142857142857 29.1 29 1 abnormal artery morphology 0.200517269982001 0.562647161963033 1.10779444307844 0.257142857142857 29.1 29 1 decreased triglyceride level 0.200517269982001 0.562647161963033 1.10779444307844 0.257142857142857 29.1 29 1 decreased glycogen level 0.200517269982001 0.562647161963033 1.10779444307844 0.257142857142857 29.1 29 1 absent gastric milk in neonates 0.0853006105184156 0.423101233628233 1.104638333554 0.256410256410256 29.1 29 1 sparse hair 0.0802101966246626 0.4135188893344 1.10329121363503 0.25609756097561 29.1 29 1 abnormal developmental patterning 0.0802101966246626 0.4135188893344 1.10329121363503 0.25609756097561 29.1 29 1 abnormal organ of Corti morphology 0.172851073371503 0.534044845004636 1.10206940719689 0.255813953488372 29.1 29 1 abnormal intestinal mucosa morphology 0.172851073371503 0.534044845004636 1.10206940719689 0.255813953488372 29.1 29 1 abnormal vasculogenesis 0.172851073371503 0.534044845004636 1.10206940719689 0.255813953488372 29.1 29 1 abnormal homeostasis 0.172851073371503 0.534044845004636 1.10206940719689 0.255813953488372 29.1 29 1 decreased oxygen consumption 0.172851073371503 0.534044845004636 1.10206940719689 0.255813953488372 29.1 29 1 increased cellular sensitivity to gamma-irradiation 0.160940438666597 0.534044845004636 1.09993774490057 0.25531914893617 29.1 29 1 failure of chorioallantoic fusion 0.15008037370965 0.534044845004636 1.09814046100368 0.254901960784314 29.1 29 1 microphthalmia 0.0255609997668434 0.214556255890999 1.09814046100368 0.254901960784314 29.1 29 1 increased circulating aspartate transaminase level 0.122604137676556 0.52396344986882 1.09411796847253 0.253968253968254 29.1 29 1 small testis 0.0043967238527212 0.0705603263460902 1.0926313951458 0.253623188405797 29.1 29 1 thymus hypoplasia 0.0352872044938049 0.245877232575422 1.0926313951458 0.253623188405797 29.1 29 1 atelectasis 0.10766357414997 0.472235865836358 1.09219170444353 0.253521126760563 29.1 29 1 corneal opacity 0.10766357414997 0.472235865836358 1.09219170444353 0.253521126760563 29.1 29 1 decreased hematocrit 0.031518142843144 0.242728731648051 1.09177610638248 0.253424657534247 29.1 29 1 decreased B cell proliferation 0.0948310120869456 0.442159592439133 1.09065556983812 0.253164556962025 29.1 29 1 abnormal spleen morphology 0.021346366648297 0.196293464763553 1.08940194274635 0.252873563218391 29.1 29 1 small spleen 0.0787539682946303 0.410692864010257 1.0888577859318 0.252747252747253 29.1 29 1 abnormal rib morphology 0.0411562896700959 0.270122085895418 1.08500031873526 0.251851851851852 29.1 29 1 abnormal axial skeleton morphology 0.111952116867653 0.486854704035467 1.07702237521515 0.25 29.1 29 1 increased erythrocyte cell number 0.145809895382356 0.534044845004636 1.07702237521515 0.25 29.1 29 1 abnormal eye physiology 0.145809895382356 0.534044845004636 1.07702237521515 0.25 29.1 29 1 increased percent body fat/body weight 0.167499449846461 0.534044845004636 1.07702237521515 0.25 29.1 29 1 head bobbing 0.20873829298735 0.579505026569234 1.07702237521515 0.25 29.1 29 1 abnormal cell proliferation 0.320174314563019 0.721378323494823 1.07702237521515 0.25 29.1 29 1 waved hair 0.320174314563019 0.721378323494823 1.07702237521515 0.25 29.1 29 1 decreased myocardial infarction size 0.320174314563019 0.721378323494823 1.07702237521515 0.25 29.1 29 1 abnormal hyoid bone morphology 0.320174314563019 0.721378323494823 1.07702237521515 0.25 29.1 29 1 abnormal heart right ventricle morphology 0.320174314563019 0.721378323494823 1.07702237521515 0.25 29.1 29 1 abnormal incus morphology 0.320174314563019 0.721378323494823 1.07702237521515 0.25 29.1 29 1 abnormal induced retinal neovascularization 0.320174314563019 0.721378323494823 1.07702237521515 0.25 29.1 29 1 increased skin tumor incidence 0.320174314563019 0.721378323494823 1.07702237521515 0.25 29.1 29 1 decreased muscle cell glucose uptake 0.320174314563019 0.721378323494823 1.07702237521515 0.25 29.1 29 1 decreased double-positive T cell number 0.0769917887666532 0.403618702965332 1.07702237521515 0.25 29.1 29 1 retinal degeneration 0.0818350387206858 0.420588138053111 1.07702237521515 0.25 29.1 29 1 oligodactyly 0.179916636866423 0.534044845004636 1.07702237521515 0.25 29.1 29 1 abnormal seminal vesicle morphology 0.156175525698841 0.534044845004636 1.07702237521515 0.25 29.1 29 1 curly tail 0.179916636866423 0.534044845004636 1.07702237521515 0.25 29.1 29 1 abnormal epidermis stratum granulosum morphology 0.225620088681652 0.615046543118475 1.07702237521515 0.25 29.1 29 1 impaired wound healing 0.225620088681652 0.615046543118475 1.07702237521515 0.25 29.1 29 1 abnormal stria vascularis morphology 0.266148652004325 0.672809727500771 1.07702237521515 0.25 29.1 29 1 rib bifurcation 0.266148652004325 0.672809727500771 1.07702237521515 0.25 29.1 29 1 abnormal jaw morphology 0.266148652004325 0.672809727500771 1.07702237521515 0.25 29.1 29 1 abnormal respiration 0.266148652004325 0.672809727500771 1.07702237521515 0.25 29.1 29 1 failure of blastocyst to hatch from the zona pellucida 0.266148652004325 0.672809727500771 1.07702237521515 0.25 29.1 29 1 decreased circulating progesterone level 0.266148652004325 0.672809727500771 1.07702237521515 0.25 29.1 29 1 prolonged QRS complex duration 0.266148652004325 0.672809727500771 1.07702237521515 0.25 29.1 29 1 abnormal foregut morphology 0.290984847555345 0.715241905428776 1.07702237521515 0.25 29.1 29 1 apnea 0.290984847555345 0.715241905428776 1.07702237521515 0.25 29.1 29 1 blindness 0.290984847555345 0.715241905428776 1.07702237521515 0.25 29.1 29 1 abnormal cardiac muscle contractility 0.290984847555345 0.715241905428776 1.07702237521515 0.25 29.1 29 1 prolonged QT interval 0.290984847555345 0.715241905428776 1.07702237521515 0.25 29.1 29 1 abnormal tumor morphology 0.290984847555345 0.715241905428776 1.07702237521515 0.25 29.1 29 1 increased hemangiosarcoma incidence 0.290984847555345 0.715241905428776 1.07702237521515 0.25 29.1 29 1 increased circulating total protein level 0.290984847555345 0.715241905428776 1.07702237521515 0.25 29.1 29 1 abnormal lung saccule morphology 0.290984847555345 0.715241905428776 1.07702237521515 0.25 29.1 29 1 abnormal heart morphology 0.0163881941910634 0.158814354612879 1.06303507164092 0.246753246753247 29.1 29 1 microcephaly 0.14098874018496 0.534044845004636 1.06141335528449 0.246376811594203 29.1 29 1 abnormal epidermal layer morphology 0.14098874018496 0.534044845004636 1.06141335528449 0.246376811594203 29.1 29 1 abnormal lipid homeostasis 0.0610559087299118 0.344391321917586 1.06045280021184 0.246153846153846 29.1 29 1 abnormal long bone morphology 0.161478403768666 0.534044845004636 1.05936627070342 0.245901639344262 29.1 29 1 absent vitelline blood vessels 0.173127072292078 0.534044845004636 1.05812724582541 0.245614035087719 29.1 29 1 abnormal pancreatic islet morphology 0.185880298426325 0.534044845004636 1.05670119832429 0.245283018867925 29.1 29 1 organ of Corti degeneration 0.199898772868975 0.562179985880807 1.05504232674137 0.244897959183673 29.1 29 1 increased sarcoma incidence 0.199898772868975 0.562179985880807 1.05504232674137 0.244897959183673 29.1 29 1 abnormal craniofacial development 0.199898772868975 0.562179985880807 1.05504232674137 0.244897959183673 29.1 29 1 abnormal autopod morphology 0.215381393460218 0.596948430342388 1.05308854465481 0.244444444444444 29.1 29 1 increased oxygen consumption 0.119431533127502 0.512217135611486 1.0519753432334 0.244186046511628 29.1 29 1 thick ventricular wall 0.232579251247648 0.618967091720245 1.05075353679526 0.24390243902439 29.1 29 1 skin inflammation 0.251816901630075 0.647101800418195 1.04791366237149 0.243243243243243 29.1 29 1 abnormal aorta morphology 0.273526072549698 0.690757467479568 1.04438533354196 0.242424242424242 29.1 29 1 increased eosinophil cell number 0.177985152608883 0.534044845004636 1.04227971795014 0.241935483870968 29.1 29 1 small ovary 0.122696968662749 0.52396344986882 1.0415161430652 0.241758241758242 29.1 29 1 abnormal middle ear morphology 0.298301802357226 0.721378323494823 1.03988367262152 0.241379310344828 29.1 29 1 abnormal parietal bone morphology 0.298301802357226 0.721378323494823 1.03988367262152 0.241379310344828 29.1 29 1 abnormal outer ear morphology 0.298301802357226 0.721378323494823 1.03988367262152 0.241379310344828 29.1 29 1 abnormal lipid level 0.139512737620909 0.534044845004636 1.03809385562906 0.240963855421687 29.1 29 1 abnormal circulating protein level 0.220813134309861 0.606124908028986 1.03394148020654 0.24 29.1 29 1 increased pre-B cell number 0.327001847231489 0.721378323494823 1.03394148020654 0.24 29.1 29 1 abnormal feces composition 0.327001847231489 0.721378323494823 1.03394148020654 0.24 29.1 29 1 abnormal preimplantation embryo development 0.327001847231489 0.721378323494823 1.03394148020654 0.24 29.1 29 1 abnormal cell death 0.238119255417608 0.618967091720245 1.03019531542318 0.239130434782609 29.1 29 1 abnormal lymphocyte physiology 0.238119255417608 0.618967091720245 1.03019531542318 0.239130434782609 29.1 29 1 maternal effect 0.182200175119915 0.534044845004636 1.02879749274283 0.238805970149254 29.1 29 1 abnormal renal glomerulus morphology 0.113464056380754 0.492393195137576 1.02761767910436 0.238532110091743 29.1 29 1 arrest of spermatogenesis 0.15230416655141 0.534044845004636 1.025735595443 0.238095238095238 29.1 29 1 increased food intake 0.15230416655141 0.534044845004636 1.025735595443 0.238095238095238 29.1 29 1 abnormal muscle morphology 0.257372875075474 0.658318793573512 1.025735595443 0.238095238095238 29.1 29 1 abnormal eye pigmentation 0.360936959023352 0.75100851992521 1.025735595443 0.238095238095238 29.1 29 1 increased incidence of induced tumors 0.360936959023352 0.75100851992521 1.025735595443 0.238095238095238 29.1 29 1 abnormal associative learning 0.360936959023352 0.75100851992521 1.025735595443 0.238095238095238 29.1 29 1 left pulmonary isomerism 0.360936959023352 0.75100851992521 1.025735595443 0.238095238095238 29.1 29 1 absent segment of posterior cerebral artery 0.360936959023352 0.75100851992521 1.025735595443 0.238095238095238 29.1 29 1 decreased B cell number 0.0445667766048285 0.288322124329027 1.0247397356416 0.237864077669903 29.1 29 1 syndactyly 0.209600405360204 0.581573907789747 1.02225852562794 0.23728813559322 29.1 29 1 increased bone marrow cell number 0.278945709631329 0.703729668060783 1.02033698704593 0.236842105263158 29.1 29 1 decreased threshold for auditory brainstem response 0.278945709631329 0.703729668060783 1.02033698704593 0.236842105263158 29.1 29 1 abnormal rostral-caudal axis patterning 0.225294103345352 0.614831686309998 1.01827570020341 0.236363636363636 29.1 29 1 abnormal cervical vertebrae morphology 0.242577060648387 0.624325337157644 1.01366811784955 0.235294117647059 29.1 29 1 abnormal thrombosis 0.242577060648387 0.624325337157644 1.01366811784955 0.235294117647059 29.1 29 1 decreased circulating alanine transaminase level 0.199022984151428 0.560667806428852 1.01366811784955 0.235294117647059 29.1 29 1 lung hemorrhage 0.303331237523624 0.721378323494823 1.01366811784955 0.235294117647059 29.1 29 1 abnormal spleen red pulp morphology 0.303331237523624 0.721378323494823 1.01366811784955 0.235294117647059 29.1 29 1 decreased leukocyte cell number 0.108338015439514 0.474038370106931 1.00626908049298 0.233576642335766 29.1 29 1 liver inflammation 0.127454795905062 0.531084438278263 1.00522088353414 0.233333333333333 29.1 29 1 absent mesoderm 0.22901490839694 0.618967091720245 1.00522088353414 0.233333333333333 29.1 29 1 gastrointestinal hemorrhage 0.331206994557436 0.721378323494823 1.00522088353414 0.233333333333333 29.1 29 1 increased metastatic potential 0.331206994557436 0.721378323494823 1.00522088353414 0.233333333333333 29.1 29 1 abnormal pain threshold 0.331206994557436 0.721378323494823 1.00522088353414 0.233333333333333 29.1 29 1 deafness 0.160526943216727 0.534044845004636 1.00086927797771 0.232323232323232 29.1 29 1 abnormal eye development 0.246190417517553 0.632970194909472 1.00009220555692 0.232142857142857 29.1 29 1 abnormal sternum morphology 0.216542755914889 0.598734938955937 0.998977275561875 0.231884057971014 29.1 29 1 abnormal coat appearance 0.216542755914889 0.598734938955937 0.998977275561875 0.231884057971014 29.1 29 1 increased B cell number 0.145887728000317 0.534044845004636 0.994174500198597 0.230769230769231 29.1 29 1 increased rib number 0.205030186692653 0.569992784783429 0.994174500198597 0.230769230769231 29.1 29 1 small liver 0.205030186692653 0.569992784783429 0.994174500198597 0.230769230769231 29.1 29 1 kinked neural tube 0.265100343888965 0.672551866826926 0.994174500198597 0.230769230769231 29.1 29 1 increased hepatocyte apoptosis 0.306836999977516 0.721378323494823 0.994174500198597 0.230769230769231 29.1 29 1 abnormal circulating hormone level 0.306836999977516 0.721378323494823 0.994174500198597 0.230769230769231 29.1 29 1 abnormal kidney cortex morphology 0.363543180644325 0.754537890573848 0.994174500198597 0.230769230769231 29.1 29 1 increased susceptibility to otitis media 0.363543180644325 0.754537890573848 0.994174500198597 0.230769230769231 29.1 29 1 increased leukemia incidence 0.363543180644325 0.754537890573848 0.994174500198597 0.230769230769231 29.1 29 1 abnormal tectorial membrane morphology 0.363543180644325 0.754537890573848 0.994174500198597 0.230769230769231 29.1 29 1 decreased T cell number 0.108123057488425 0.473514270250803 0.990057835601501 0.229813664596273 29.1 29 1 abnormal urine homeostasis 0.184454233289376 0.534044845004636 0.987270510613884 0.229166666666667 29.1 29 1 abnormal intestinal epithelium morphology 0.286016141446739 0.711078384517961 0.987270510613884 0.229166666666667 29.1 29 1 abnormal cardiovascular system morphology 0.286016141446739 0.711078384517961 0.987270510613884 0.229166666666667 29.1 29 1 abnormal lymph node morphology 0.286016141446739 0.711078384517961 0.987270510613884 0.229166666666667 29.1 29 1 dehydration 0.234713708088995 0.618967091720245 0.984706171625277 0.228571428571429 29.1 29 1 abnormal embryonic epiblast morphology 0.333794635313734 0.721378323494823 0.984706171625277 0.228571428571429 29.1 29 1 holoprosencephaly 0.333794635313734 0.721378323494823 0.984706171625277 0.228571428571429 29.1 29 1 decreased circulating thyroxine level 0.333794635313734 0.721378323494823 0.984706171625277 0.228571428571429 29.1 29 1 abnormal myocardium layer morphology 0.221582721711982 0.606124908028986 0.981590012854311 0.227848101265823 29.1 29 1 abnormal cytokine secretion 0.129521001702065 0.534044845004636 0.979111250195588 0.227272727272727 29.1 29 1 abnormal abdominal fat pad morphology 0.401806115908504 0.797972495649213 0.979111250195588 0.227272727272727 29.1 29 1 abnormal enterocyte morphology 0.401806115908504 0.797972495649213 0.979111250195588 0.227272727272727 29.1 29 1 increased activated T cell number 0.401806115908504 0.797972495649213 0.979111250195588 0.227272727272727 29.1 29 1 intestinal inflammation 0.401806115908504 0.797972495649213 0.979111250195588 0.227272727272727 29.1 29 1 abnormal oogenesis 0.401806115908504 0.797972495649213 0.979111250195588 0.227272727272727 29.1 29 1 increased skin papilloma incidence 0.401806115908504 0.797972495649213 0.979111250195588 0.227272727272727 29.1 29 1 abnormal cochlear sensory epithelium morphology 0.401806115908504 0.797972495649213 0.979111250195588 0.227272727272727 29.1 29 1 abnormal blood-brain barrier function 0.401806115908504 0.797972495649213 0.979111250195588 0.227272727272727 29.1 29 1 decreased circulating estradiol level 0.401806115908504 0.797972495649213 0.979111250195588 0.227272727272727 29.1 29 1 abnormal sperm midpiece morphology 0.401806115908504 0.797972495649213 0.979111250195588 0.227272727272727 29.1 29 1 failure of palatal shelf elevation 0.401806115908504 0.797972495649213 0.979111250195588 0.227272727272727 29.1 29 1 increased adenoma incidence 0.401806115908504 0.797972495649213 0.979111250195588 0.227272727272727 29.1 29 1 abnormal placenta development 0.288286698658518 0.712836146036842 0.975416490760887 0.226415094339623 29.1 29 1 abnormal eyelid morphology 0.364591289618058 0.755366653609493 0.972794403420132 0.225806451612903 29.1 29 1 abnormal body temperature homeostasis 0.364591289618058 0.755366653609493 0.972794403420132 0.225806451612903 29.1 29 1 abnormal definitive hematopoiesis 0.211364286483101 0.58614120694171 0.972794403420132 0.225806451612903 29.1 29 1 abnormal CD4-positive, alpha-beta T cell physiology 0.25348542387145 0.651053166629048 0.97083707061647 0.225352112676056 29.1 29 1 increased T cell derived lymphoma incidence 0.310944853403461 0.721378323494823 0.967122132846254 0.224489795918367 29.1 29 1 abnormal spermiogenesis 0.289971274198524 0.715241905428776 0.965606267434269 0.224137931034483 29.1 29 1 glomerulosclerosis 0.289971274198524 0.715241905428776 0.965606267434269 0.224137931034483 29.1 29 1 abnormal femur morphology 0.271530451998823 0.686066022698904 0.9644976494464 0.223880597014925 29.1 29 1 decreased T cell proliferation 0.164860534646267 0.534044845004636 0.960587523840536 0.222972972972973 29.1 29 1 abnormal cochlea morphology 0.312035263635582 0.721378323494823 0.957353222413464 0.222222222222222 29.1 29 1 abnormal mandible morphology 0.312035263635582 0.721378323494823 0.957353222413464 0.222222222222222 29.1 29 1 wrinkled skin 0.400263150583373 0.797972495649213 0.957353222413464 0.222222222222222 29.1 29 1 abnormal reflex 0.364701648637186 0.755366653609493 0.957353222413463 0.222222222222222 29.1 29 1 decreased birth weight 0.242507020968579 0.624325337157644 0.952314521242866 0.221052631578947 29.1 29 1 increased B cell proliferation 0.312684780609354 0.721378323494823 0.949240059511654 0.220338983050847 29.1 29 1 abnormal liver physiology 0.243348195690596 0.625986180744941 0.947779690189329 0.22 29.1 29 1 increased tumor growth/size 0.364212337452319 0.755296531398619 0.945678183115738 0.219512195121951 29.1 29 1 short ulna 0.364212337452319 0.755296531398619 0.945678183115738 0.219512195121951 29.1 29 1 abnormal blood homeostasis 0.230527139470266 0.618967091720245 0.94475646948697 0.219298245614035 29.1 29 1 decreased lymphocyte cell number 0.21872674191572 0.60086446219255 0.942394578313253 0.21875 29.1 29 1 abnormal vertebral body morphology 0.398190470283684 0.797972495649213 0.942394578313253 0.21875 29.1 29 1 abnormal lymphatic vessel morphology 0.398190470283684 0.797972495649213 0.942394578313253 0.21875 29.1 29 1 abnormal diaphragm morphology 0.398190470283684 0.797972495649213 0.942394578313253 0.21875 29.1 29 1 abnormal lumbar vertebrae morphology 0.398190470283684 0.797972495649213 0.942394578313253 0.21875 29.1 29 1 abnormal T cell differentiation 0.259201031158835 0.662313882904572 0.938395732860722 0.217821782178218 29.1 29 1 delayed wound healing 0.363323000445374 0.754537890573848 0.936541195839258 0.217391304347826 29.1 29 1 abnormal blood vessel physiology 0.442348178092219 0.824850509272831 0.936541195839258 0.217391304347826 29.1 29 1 abnormal retinal cone cell morphology 0.442348178092219 0.824850509272831 0.936541195839258 0.217391304347826 29.1 29 1 abnormal innervation pattern to muscle 0.442348178092219 0.824850509272831 0.936541195839258 0.217391304347826 29.1 29 1 conjunctivitis 0.442348178092219 0.824850509272831 0.936541195839258 0.217391304347826 29.1 29 1 abnormal nasal cavity morphology 0.442348178092219 0.824850509272831 0.936541195839258 0.217391304347826 29.1 29 1 abnormal cardiovascular development 0.442348178092219 0.824850509272831 0.936541195839258 0.217391304347826 29.1 29 1 abnormal crista ampullaris morphology 0.442348178092219 0.824850509272831 0.936541195839258 0.217391304347826 29.1 29 1 decreased epididymis weight 0.442348178092219 0.824850509272831 0.936541195839258 0.217391304347826 29.1 29 1 dilated heart 0.442348178092219 0.824850509272831 0.936541195839258 0.217391304347826 29.1 29 1 epidermal hyperplasia 0.335827511221298 0.721378323494823 0.933419391853127 0.216666666666667 29.1 29 1 small seminiferous tubules 0.312843796966687 0.721378323494823 0.931478810996883 0.216216216216216 29.1 29 1 abnormal gastrulation 0.362158749238997 0.753235692919737 0.92919577469542 0.215686274509804 29.1 29 1 thick epidermis 0.334383981943957 0.721378323494823 0.923162035898697 0.214285714285714 29.1 29 1 abnormal somite shape 0.436839832014022 0.824850509272831 0.923162035898697 0.214285714285714 29.1 29 1 abnormal retinal inner nuclear layer morphology 0.436839832014022 0.824850509272831 0.923162035898697 0.214285714285714 29.1 29 1 corneal vascularization 0.436839832014022 0.824850509272831 0.923162035898697 0.214285714285714 29.1 29 1 azoospermia 0.232435505503098 0.618967091720245 0.921226685718616 0.213836477987421 29.1 29 1 increased circulating glucose level 0.258818894564289 0.661677286977048 0.916614787417146 0.212765957446809 29.1 29 1 hepatic necrosis 0.390788224444911 0.790357992980029 0.916614787417146 0.212765957446809 29.1 29 1 increased respiratory quotient 0.390788224444911 0.790357992980029 0.916614787417146 0.212765957446809 29.1 29 1 abnormal retinal pigment epithelium morphology 0.332395484770574 0.721378323494823 0.915469018932874 0.2125 29.1 29 1 increased spleen weight 0.290968353901953 0.715241905428776 0.91499246035977 0.212389380530973 29.1 29 1 abnormal tail morphology 0.357715365794995 0.745865022979925 0.913837166849215 0.212121212121212 29.1 29 1 abnormal QRS complex 0.431753961981297 0.824850509272831 0.913837166849215 0.212121212121212 29.1 29 1 head tossing 0.431753961981297 0.824850509272831 0.913837166849215 0.212121212121212 29.1 29 1 increased sensitivity to induced morbidity/mortality 0.231362284887625 0.618967091720245 0.913127665943276 0.21195652173913 29.1 29 1 increased hepatocellular carcinoma incidence 0.385608137540582 0.790357992980029 0.906966210707492 0.210526315789474 29.1 29 1 abnormal trabecular bone morphology 0.306074472473124 0.721378323494823 0.905060819508526 0.210084033613445 29.1 29 1 rib fusion 0.380481192080777 0.787721152976223 0.900197806149973 0.208955223880597 29.1 29 1 abnormal hair shaft morphology 0.418359825233903 0.824850509272831 0.897518646012622 0.208333333333333 29.1 29 1 abnormal malleus morphology 0.482180633496659 0.850354006255186 0.897518646012622 0.208333333333333 29.1 29 1 abnormal digestive system morphology 0.482180633496659 0.850354006255186 0.897518646012622 0.208333333333333 29.1 29 1 abnormal adrenal gland morphology 0.482180633496659 0.850354006255186 0.897518646012622 0.208333333333333 29.1 29 1 curly vibrissae 0.482180633496659 0.850354006255186 0.897518646012622 0.208333333333333 29.1 29 1 increased body temperature 0.482180633496659 0.850354006255186 0.897518646012622 0.208333333333333 29.1 29 1 abnormal truncus arteriosus septation 0.482180633496659 0.850354006255186 0.897518646012622 0.208333333333333 29.1 29 1 abnormal microglial cell morphology 0.472980187576664 0.837041542902593 0.891328862247018 0.206896551724138 29.1 29 1 abnormal embryonic erythropoiesis 0.472980187576664 0.837041542902593 0.891328862247018 0.206896551724138 29.1 29 1 decreased cytotoxic T cell cytolysis 0.465048742396249 0.824850509272831 0.886959603118356 0.205882352941176 29.1 29 1 abnormal skin physiology 0.465048742396249 0.824850509272831 0.886959603118356 0.205882352941176 29.1 29 1 increased urine protein level 0.396779235750155 0.797972495649213 0.883710666843197 0.205128205128205 29.1 29 1 abnormal iris morphology 0.458028280128198 0.824850509272831 0.883710666843197 0.205128205128205 29.1 29 1 abnormal lens fiber morphology 0.458028280128198 0.824850509272831 0.883710666843197 0.205128205128205 29.1 29 1 decreased B-1 B cell number 0.458028280128198 0.824850509272831 0.883710666843197 0.205128205128205 29.1 29 1 decreased trabecular bone volume 0.458028280128198 0.824850509272831 0.883710666843197 0.205128205128205 29.1 29 1 abnormal myelopoiesis 0.451695591886973 0.824850509272831 0.881200125176029 0.204545454545455 29.1 29 1 increased circulating LDL cholesterol level 0.445902125703247 0.824850509272831 0.87920193895114 0.204081632653061 29.1 29 1 abnormal maxilla morphology 0.440543965204295 0.824850509272831 0.877573787212342 0.203703703703704 29.1 29 1 decreased tumor growth/size 0.440543965204295 0.824850509272831 0.877573787212342 0.203703703703704 29.1 29 1 decreased eosinophil cell number 0.430849972070128 0.824850509272831 0.875080679862306 0.203125 29.1 29 1 abnormal food intake 0.426413590077651 0.824850509272831 0.87410511611664 0.202898550724638 29.1 29 1 increased granulocyte number 0.422201868800541 0.824850509272831 0.873261385309578 0.202702702702703 29.1 29 1 decreased inflammatory response 0.414346741962996 0.821592284282943 0.871875256126547 0.202380952380952 29.1 29 1 abnormal immune system physiology 0.388164871822554 0.790357992980029 0.868566431625118 0.201612903225806 29.1 29 1 decreased osteoclast cell number 0.480593291107576 0.849361145030263 0.861617900172117 0.2 29.1 29 1 abnormal metabolism 0.480593291107576 0.849361145030263 0.861617900172117 0.2 29.1 29 1 increased monocyte cell number 0.422743177113621 0.824850509272831 0.861617900172117 0.2 29.1 29 1 abnormal digestive system physiology 0.473286002047235 0.837041542902593 0.861617900172117 0.2 29.1 29 1 increased B cell derived lymphoma incidence 0.473286002047235 0.837041542902593 0.861617900172117 0.2 29.1 29 1 decreased circulating alkaline phosphatase level 0.473286002047235 0.837041542902593 0.861617900172117 0.2 29.1 29 1 testicular atrophy 0.473286002047235 0.837041542902593 0.861617900172117 0.2 29.1 29 1 abnormal estrous cycle 0.508423485831472 0.88751117263564 0.861617900172117 0.2 29.1 29 1 abnormal spleen marginal zone morphology 0.508423485831472 0.88751117263564 0.861617900172117 0.2 29.1 29 1 abnormal inner ear vestibule morphology 0.520975330062952 0.907511297991312 0.861617900172117 0.2 29.1 29 1 ruffled hair 0.520975330062952 0.907511297991312 0.861617900172117 0.2 29.1 29 1 abnormal egg cylinder morphology 0.520975330062952 0.907511297991312 0.861617900172117 0.2 29.1 29 1 decreased acute inflammation 0.520975330062952 0.907511297991312 0.861617900172117 0.2 29.1 29 1 abnormal humoral immune response 0.418946600600648 0.824850509272831 0.861617900172117 0.2 29.1 29 1 decreased neutrophil cell number 0.447227734129074 0.824850509272831 0.846889389058064 0.196581196581197 29.1 29 1 abnormal dendritic cell physiology 0.456149982442941 0.824850509272831 0.845512892692264 0.196261682242991 29.1 29 1 increased lung adenocarcinoma incidence 0.500390210049245 0.877800174539842 0.844723431541291 0.196078431372549 29.1 29 1 abnormal cholesterol homeostasis 0.518886322485631 0.905140061138154 0.840602829436212 0.195121951219512 29.1 29 1 abnormal systemic arterial blood pressure 0.530004487915424 0.910487682106088 0.83768406961178 0.194444444444444 29.1 29 1 short radius 0.530004487915424 0.910487682106088 0.83768406961178 0.194444444444444 29.1 29 1 abnormal retinal blood vessel morphology 0.530004487915424 0.910487682106088 0.83768406961178 0.194444444444444 29.1 29 1 osteopetrosis 0.542943212922691 0.920109331021651 0.833823774360113 0.193548387096774 29.1 29 1 autoimmune response 0.542943212922691 0.920109331021651 0.833823774360113 0.193548387096774 29.1 29 1 increased lung adenoma incidence 0.542943212922691 0.920109331021651 0.833823774360113 0.193548387096774 29.1 29 1 decreased double-negative T cell number 0.542943212922691 0.920109331021651 0.833823774360113 0.193548387096774 29.1 29 1 abnormal podocyte morphology 0.542943212922691 0.920109331021651 0.833823774360113 0.193548387096774 29.1 29 1 abnormal intestine physiology 0.542943212922691 0.920109331021651 0.833823774360113 0.193548387096774 29.1 29 1 increased liver weight 0.497187165587891 0.872488941375576 0.832244562666249 0.193181818181818 29.1 29 1 increased circulating alanine transaminase level 0.510419627098253 0.890683144445391 0.828478750165497 0.192307692307692 29.1 29 1 abnormal female meiosis 0.527102448344075 0.908011560610818 0.828478750165497 0.192307692307692 29.1 29 1 small seminal vesicle 0.558459175162625 0.920109331021651 0.828478750165497 0.192307692307692 29.1 29 1 thick skin 0.558459175162625 0.920109331021651 0.828478750165497 0.192307692307692 29.1 29 1 abnormal ocular fundus morphology 0.558459175162625 0.920109331021651 0.828478750165497 0.192307692307692 29.1 29 1 abnormal erythrocyte osmotic lysis 0.558459175162625 0.920109331021651 0.828478750165497 0.192307692307692 29.1 29 1 decreased susceptibility to injury 0.525529830612657 0.908011560610818 0.823605345752759 0.191176470588235 29.1 29 1 abnormal response to infection 0.532036621746339 0.91366316644392 0.817991677378592 0.189873417721519 29.1 29 1 abnormal long bone metaphysis morphology 0.561309005778738 0.920109331021651 0.815043959622273 0.189189189189189 29.1 29 1 hyperkeratosis 0.548538957879712 0.920109331021651 0.811669036394023 0.188405797101449 29.1 29 1 abnormal embryonic hematopoiesis 0.576347691993232 0.935812587358462 0.80776678141136 0.1875 29.1 29 1 abnormal spongiotrophoblast layer morphology 0.576347691993232 0.935812587358462 0.80776678141136 0.1875 29.1 29 1 increased fatty acid level 0.576347691993232 0.935812587358462 0.80776678141136 0.1875 29.1 29 1 abnormal kidney physiology 0.564555840699197 0.920109331021651 0.80776678141136 0.1875 29.1 29 1 increased leukocyte cell number 0.560521818077079 0.920109331021651 0.802195976022316 0.186206896551724 29.1 29 1 decreased macrophage cell number 0.6050802150413 0.965450311042485 0.78328900015647 0.181818181818182 29.1 29 1 abnormal T cell subpopulation ratio 0.608479631995884 0.96994109874384 0.78328900015647 0.181818181818182 29.1 29 1 abnormal middle ear ossicle morphology 0.608479631995884 0.96994109874384 0.78328900015647 0.181818181818182 29.1 29 1 decreased sensitivity to xenobiotic induced morbidity/mortality 0.608479631995884 0.96994109874384 0.78328900015647 0.181818181818182 29.1 29 1 increased susceptibility to bacterial infection induced morbidity/mortality 0.614913961719852 0.979883715424813 0.777849493210939 0.180555555555556 29.1 29 1 abnormal male meiosis 0.615461008317043 0.980072042085908 0.776868598515843 0.180327868852459 29.1 29 1 small lens 0.620859678417048 0.985255789513497 0.773246833487797 0.179487179487179 29.1 29 1 acanthosis 0.620859678417048 0.985255789513497 0.773246833487797 0.179487179487179 29.1 29 1 increased autoantibody level 0.620859678417048 0.985255789513497 0.773246833487797 0.179487179487179 29.1 29 1 hypoxia 0.628667813872985 0.991434832436178 0.769301696582247 0.178571428571429 29.1 29 1 abnormal retinal photoreceptor morphology 0.639214822624377 0.991434832436178 0.760251088387162 0.176470588235294 29.1 29 1 abnormal immune system morphology 0.657865319283345 1 0.749232956671406 0.173913043478261 29.1 29 1 abnormal allantois morphology 0.657865319283345 1 0.749232956671406 0.173913043478261 29.1 29 1 increased susceptibility to injury 0.666251069225791 1 0.745630875148947 0.173076923076923 29.1 29 1 stomach inflammation 0.661102736018051 1 0.742774051872515 0.172413793103448 29.1 29 1 increased susceptibility to induced arthritis 0.661102736018051 1 0.742774051872515 0.172413793103448 29.1 29 1 abnormal intestinal goblet cell morphology 0.668460178512136 1 0.738529628718957 0.171428571428571 29.1 29 1 arrested B cell differentiation 0.67565820028366 1 0.735527475756685 0.170731707317073 29.1 29 1 increased circulating bilirubin level 0.689350572363503 1 0.731562368070665 0.169811320754717 29.1 29 1 lung inflammation 0.749703007909533 1 0.728573959704364 0.169117647058824 29.1 29 1 increased cell proliferation 0.71143046293714 1 0.718014916810098 0.166666666666667 29.1 29 1 salivary gland inflammation 0.691638586055368 1 0.718014916810098 0.166666666666667 29.1 29 1 abnormal vibrissa morphology 0.701105001733165 1 0.718014916810098 0.166666666666667 29.1 29 1 abnormal double-strand DNA break repair 0.725199176731737 1 0.701316895488932 0.162790697674419 29.1 29 1 impaired skeletal muscle contractility 0.722249828409429 1 0.698609108247662 0.162162162162162 29.1 29 1 increased insulin secretion 0.722249828409429 1 0.698609108247662 0.162162162162162 29.1 29 1 increased lymphocyte cell number 0.775413919567941 1 0.686796876948789 0.159420289855072 29.1 29 1 impaired natural killer cell mediated cytotoxicity 0.771359850112742 1 0.680224658030619 0.157894736842105 29.1 29 1 increased macrophage cell number 0.771359850112742 1 0.680224658030619 0.157894736842105 29.1 29 1 increased vascular permeability 0.769627785440571 1 0.662783000132398 0.153846153846154 29.1 29 1 failure of heart looping 0.769627785440571 1 0.662783000132398 0.153846153846154 29.1 29 1 abnormal inner ear morphology 0.789276985635483 1 0.65557883708748 0.152173913043478 29.1 29 1 scaly skin 0.810695627615468 1 0.630452122077159 0.146341463414634 29.1 29 1 abnormal T-helper 2 physiology 0.838471779985458 1 0.626631200125176 0.145454545454545 29.1 29 1 increased neutrophil cell number 0.930496963126604 1 0.623930203572912 0.144827586206897 29.1 29 1 decreased IgM level 0.896056416713758 1 0.62178611352627 0.144329896907216 29.1 29 1 decreased IgG level 0.909546486184187 1 0.620985873997922 0.144144144144144 29.1 29 1 abnormal epidermis stratum corneum morphology 0.84140722832356 1 0.615441357265798 0.142857142857143 29.1 29 1 abnormal spleen white pulp morphology 0.828960731929185 1 0.615441357265798 0.142857142857143 29.1 29 1 abnormal cytotoxic T cell physiology 0.828960731929185 1 0.615441357265798 0.142857142857143 29.1 29 1 increased red blood cell distribution width 0.815410535500299 1 0.615441357265798 0.142857142857143 29.1 29 1 increased erythroid progenitor cell number 0.852207778534388 1 0.582174256873052 0.135135135135135 29.1 29 1 abnormal NK cell physiology 0.90982276824424 1 0.564995344375159 0.131147540983607 29.1 29 1 abnormal leukocyte adhesion 0.882681789875279 1 0.552319166776998 0.128205128205128 29.1 29 1 impaired hematopoiesis 0.937045199360281 1 0.506834058924775 0.117647058823529 29.1 29 1 decreased sensitivity to induced morbidity/mortality 0.936296919058494 1 0.489555625097794 0.113636363636364 29.1 29 1 altered response to myocardial infarction 0.943910721007215 1 0.478676611206732 0.111111111111111 29.1 29 1 increased susceptibility to parasitic infection 0.983166360782197 1 0.478676611206732 0.111111111111111 29.1 29 1 decreased susceptibility to induced arthritis 0.969929341759798 1 0.453483105353746 0.105263157894737 29.1 29 1 decreased IgA level 0.977916436428592 1 0.414239375082749 0.0961538461538462 29.1 29 1 abnormal leukocyte migration 0.977916436428592 1 0.414239375082749 0.0961538461538462 29.1 29 1 increased circulating ferritin level 2.91678708015973e-05 0.000721941080785803 2.6877921513208 1 3.1 3 1 hemoglobinuria 0.000397086497019412 0.00604130068095282 2.6877921513208 1 3.1 3 1 abnormal hepatobiliary system physiology 0.000397086497019412 0.00604130068095282 2.6877921513208 1 3.1 3 1 abnormal circulating alanine transaminase level 0.000107624746951455 0.00209153560970113 2.6877921513208 1 3.1 3 1 decreased brain cholesterol level 0.000107624746951455 0.00209153560970113 2.6877921513208 1 3.1 3 1 vascular inflammation 0.00146495289236474 0.0172296469019258 2.6877921513208 1 3.1 3 1 increased urine microalbumin level 0.00146495289236474 0.0172296469019258 2.6877921513208 1 3.1 3 1 decreased unsaturated fatty acid level 0.00146495289236474 0.0172296469019258 2.6877921513208 1 3.1 3 1 aciduria 0.00146495289236474 0.0172296469019258 2.6877921513208 1 3.1 3 1 increased T follicular helper cell number 0.00146495289236474 0.0172296469019258 2.6877921513208 1 3.1 3 1 prolonged ST segment 0.00146495289236474 0.0172296469019258 2.6877921513208 1 3.1 3 1 abnormal blood pressure regulation 0.00146495289236474 0.0172296469019258 2.6877921513208 1 3.1 3 1 abnormal alveolar lamellar body morphology 0.00146495289236474 0.0172296469019258 2.6877921513208 1 3.1 3 1 increased heart iron level 0.00146495289236474 0.0172296469019258 2.6877921513208 1 3.1 3 1 positive geotaxis 0.00019927651700268 0.00336068024436723 2.38914857895182 0.888888888888889 3.1 3 1 abnormal cerebellum deep nucleus morphology 0.000656822880000458 0.00910221122006206 2.3518181324057 0.875 3.1 3 1 abnormal circulating lipid level 1.06178170002947e-08 6.86021293200856e-07 2.32127503977705 0.863636363636364 3.1 3 1 abnormal hematopoietic system physiology 3.39630059730918e-08 2.01149946090633e-06 2.30382184398925 0.857142857142857 3.1 3 1 abnormal circulating free fatty acids level 0.00213385699742715 0.0229285930069116 2.30382184398925 0.857142857142857 3.1 3 1 decreased activated T cell number 0.00213385699742715 0.0229285930069116 2.30382184398925 0.857142857142857 3.1 3 1 abnormal cochlear nerve compound action potential 0.00213385699742715 0.0229285930069116 2.30382184398925 0.857142857142857 3.1 3 1 thick mitral valve cusps 0.00213385699742715 0.0229285930069116 2.30382184398925 0.857142857142857 3.1 3 1 decreased circulating VLDL cholesterol level 1.07847183875019e-07 5.53133752348678e-06 2.28462332862268 0.85 3.1 3 1 increased circulating ammonia level 2.55934010767654e-05 0.000649628420188306 2.27428566650221 0.846153846153846 3.1 3 1 increased liver cholesterol level 3.39713000323769e-07 1.53642925146432e-05 2.26340391690172 0.842105263157895 3.1 3 1 abnormal amino acid level 4.59283145723929e-15 9.52055687490228e-13 2.26018885451976 0.840909090909091 3.1 3 1 increased hepatocyte proliferation 8.03691176170887e-05 0.00172343258683197 2.23982679276733 0.833333333333333 3.1 3 1 echinocytosis 0.00680428486909138 0.0528101672757092 2.23982679276733 0.833333333333333 3.1 3 1 delayed brain development 0.00680428486909138 0.0528101672757092 2.23982679276733 0.833333333333333 3.1 3 1 abnormal lymph node cortex morphology 0.00680428486909138 0.0528101672757092 2.23982679276733 0.833333333333333 3.1 3 1 calcified joint 0.00680428486909138 0.0528101672757092 2.23982679276733 0.833333333333333 3.1 3 1 increased urine uric acid level 0.00680428486909138 0.0528101672757092 2.23982679276733 0.833333333333333 3.1 3 1 exostosis 0.00680428486909138 0.0528101672757092 2.23982679276733 0.833333333333333 3.1 3 1 abnormal olfactory bulb layer morphology 0.00680428486909138 0.0528101672757092 2.23982679276733 0.833333333333333 3.1 3 1 abnormal hepatocyte physiology 4.53894230936189e-08 2.59554459644545e-06 2.22035003804761 0.826086956521739 3.1 3 1 decreased liver cholesterol level 1.00184991646106e-05 0.000276900185244099 2.18383112294815 0.8125 3.1 3 1 abnormal secondary palate development 3.02321611783893e-05 0.000744579217141024 2.15023372105664 0.8 3.1 3 1 ketoaciduria 0.0007573171408871 0.0102104411271364 2.15023372105664 0.8 3.1 3 1 decreased circulating lactate level 0.0007573171408871 0.0102104411271364 2.15023372105664 0.8 3.1 3 1 abnormal circulating cholesterol level 2.0888207056524e-08 1.29898537632759e-06 2.11183669032348 0.785714285714286 3.1 3 1 vascular smooth muscle hypoplasia 8.99121842715736e-05 0.00183033970614628 2.11183669032348 0.785714285714286 3.1 3 1 abnormal inguinal fat pad morphology 0.00225823515049269 0.0237831428863362 2.09050500658284 0.777777777777778 3.1 3 1 decreased susceptibility to atherosclerosis 0.00225823515049269 0.0237831428863362 2.09050500658284 0.777777777777778 3.1 3 1 abnormal liver vasculature morphology 0.00225823515049269 0.0237831428863362 2.09050500658284 0.777777777777778 3.1 3 1 iris coloboma 0.00225823515049269 0.0237831428863362 2.09050500658284 0.777777777777778 3.1 3 1 abnormal infrahyoid muscle connection 0.00225823515049269 0.0237831428863362 2.09050500658284 0.777777777777778 3.1 3 1 decreased fatty acid oxidation 0.00225823515049269 0.0237831428863362 2.09050500658284 0.777777777777778 3.1 3 1 anal atresia 0.000262954839418167 0.00430329054639928 2.06753242409292 0.769230769230769 3.1 3 1 liver degeneration 3.97220450983259e-06 0.000118333637343815 2.04784163910156 0.761904761904762 3.1 3 1 abnormal bile salt homeostasis 3.97220450983259e-06 0.000118333637343815 2.04784163910156 0.761904761904762 3.1 3 1 abnormal circulating amino acid level 4.1876764632795e-14 7.44060371600554e-12 2.02763267555779 0.754385964912281 3.1 3 1 decreased fatty acid level 1.41821418223285e-06 5.0759824148262e-05 2.0158441134906 0.75 3.1 3 1 disorganized yolk sac vascular plexus 9.08731472197251e-05 0.00183033970614628 2.0158441134906 0.75 3.1 3 1 bowed tibia 9.08731472197251e-05 0.00183033970614628 2.0158441134906 0.75 3.1 3 1 abnormal embryonic growth/weight/body size 0.000754128312145723 0.0102104411271364 2.0158441134906 0.75 3.1 3 1 hematuria 0.000754128312145723 0.0102104411271364 2.0158441134906 0.75 3.1 3 1 abnormal bone marrow development 0.00656495934970723 0.0517609913712789 2.0158441134906 0.75 3.1 3 1 abnormal cellular cholesterol metabolism 0.00656495934970723 0.0517609913712789 2.0158441134906 0.75 3.1 3 1 increased cardiac output 0.00656495934970723 0.0517609913712789 2.0158441134906 0.75 3.1 3 1 abnormal extraembryonic tissue physiology 0.00656495934970723 0.0517609913712789 2.0158441134906 0.75 3.1 3 1 bowed fibula 0.00656495934970723 0.0517609913712789 2.0158441134906 0.75 3.1 3 1 abnormal ilium morphology 0.00656495934970723 0.0517609913712789 2.0158441134906 0.75 3.1 3 1 abnormal meiotic spindle morphology 0.00656495934970723 0.0517609913712789 2.0158441134906 0.75 3.1 3 1 abnormal sphingomyelin level 0.00656495934970723 0.0517609913712789 2.0158441134906 0.75 3.1 3 1 abnormal circulating serum amyloid protein level 0.00656495934970723 0.0517609913712789 2.0158441134906 0.75 3.1 3 1 pleural effusion 0.00656495934970723 0.0517609913712789 2.0158441134906 0.75 3.1 3 1 abnormal heart echocardiography feature 0.00656495934970723 0.0517609913712789 2.0158441134906 0.75 3.1 3 1 decreased white adipose tissue mass 0.00656495934970723 0.0517609913712789 2.0158441134906 0.75 3.1 3 1 decreased glycogen level 8.40218851866852e-09 5.64876863248323e-07 1.99664559812402 0.742857142857143 3.1 3 1 abnormal liver physiology 2.09599249499779e-22 1.30344533282675e-19 1.98896619197739 0.74 3.1 3 1 abnormal triglyceride level 3.14099533990958e-05 0.000769775951529565 1.98047842728901 0.736842105263158 3.1 3 1 decreased thymocyte apoptosis 0.000254032247777831 0.00417099152704524 1.97104757763525 0.733333333333333 3.1 3 1 loss of cortex neurons 0.00211333907325471 0.0229060171883272 1.95475792823331 0.727272727272727 3.1 3 1 increased glycogen level 0.00211333907325471 0.0229060171883272 1.95475792823331 0.727272727272727 3.1 3 1 cortical renal glomerulopathies 8.62292148015302e-05 0.00178004291965814 1.94118322039835 0.722222222222222 3.1 3 1 abnormal iron level 8.62292148015302e-05 0.00178004291965814 1.94118322039835 0.722222222222222 3.1 3 1 decreased triglyceride level 6.01162720779589e-08 3.34128539666523e-06 1.91985153665771 0.714285714285714 3.1 3 1 lymphoid hyperplasia 1.31221493210553e-06 4.80019800531252e-05 1.91985153665771 0.714285714285714 3.1 3 1 abnormal blood flow velocity 0.00069556147728465 0.00948059821778393 1.91985153665771 0.714285714285714 3.1 3 1 cellular necrosis 0.018480354548252 0.115468534767828 1.91985153665771 0.714285714285714 3.1 3 1 absent hair follicles 0.018480354548252 0.115468534767828 1.91985153665771 0.714285714285714 3.1 3 1 mammary gland hyperplasia 0.018480354548252 0.115468534767828 1.91985153665771 0.714285714285714 3.1 3 1 absent epidermis stratum corneum 0.018480354548252 0.115468534767828 1.91985153665771 0.714285714285714 3.1 3 1 absent amniotic folds 0.018480354548252 0.115468534767828 1.91985153665771 0.714285714285714 3.1 3 1 abnormal superior semicircular canal morphology 0.018480354548252 0.115468534767828 1.91985153665771 0.714285714285714 3.1 3 1 absent tunnel of Corti 0.018480354548252 0.115468534767828 1.91985153665771 0.714285714285714 3.1 3 1 decreased cholesterol efflux 0.018480354548252 0.115468534767828 1.91985153665771 0.714285714285714 3.1 3 1 abnormal ciliary body morphology 0.018480354548252 0.115468534767828 1.91985153665771 0.714285714285714 3.1 3 1 absent fibula 0.018480354548252 0.115468534767828 1.91985153665771 0.714285714285714 3.1 3 1 abnormal thyroid hormone level 0.018480354548252 0.115468534767828 1.91985153665771 0.714285714285714 3.1 3 1 retinal pigment epithelium atrophy 0.018480354548252 0.115468534767828 1.91985153665771 0.714285714285714 3.1 3 1 abnormal renal filtration rate 0.018480354548252 0.115468534767828 1.91985153665771 0.714285714285714 3.1 3 1 decreased skeletal muscle glycogen level 0.018480354548252 0.115468534767828 1.91985153665771 0.714285714285714 3.1 3 1 coronary fistula 0.018480354548252 0.115468534767828 1.91985153665771 0.714285714285714 3.1 3 1 embryo tumor 0.018480354548252 0.115468534767828 1.91985153665771 0.714285714285714 3.1 3 1 abnormal lipid homeostasis 4.00044568210064e-25 3.31703621140845e-22 1.90212983016549 0.707692307692308 3.1 3 1 abnormal cholesterol homeostasis 7.43691864687238e-09 5.06831099564247e-07 1.90112127776349 0.707317073170732 3.1 3 1 abnormal gluconeogenesis 1.24086050500069e-10 1.28610021091217e-08 1.89726504799115 0.705882352941177 3.1 3 1 increased circulating alanine transaminase level 1.74075217273641e-15 3.76532263450592e-13 1.89523805541851 0.705128205128205 3.1 3 1 absent ductus venosus valve 7.84424705775477e-05 0.00169595523150271 1.88145450592456 0.7 3.1 3 1 decreased muscle cell glucose uptake 7.84424705775477e-05 0.00169595523150271 1.88145450592456 0.7 3.1 3 1 increased cranium width 0.0057603771729057 0.0480836852939696 1.88145450592456 0.7 3.1 3 1 abnormal immune cell physiology 0.0057603771729057 0.0480836852939696 1.88145450592456 0.7 3.1 3 1 abnormal gonadal fat pad morphology 0.0057603771729057 0.0480836852939696 1.88145450592456 0.7 3.1 3 1 increased susceptibility to atherosclerosis 0.0057603771729057 0.0480836852939696 1.88145450592456 0.7 3.1 3 1 increased kidney iron level 0.0057603771729057 0.0480836852939696 1.88145450592456 0.7 3.1 3 1 thin ventricle myocardium compact layer 0.0057603771729057 0.0480836852939696 1.88145450592456 0.7 3.1 3 1 increased fatty acid oxidation 0.0057603771729057 0.0480836852939696 1.88145450592456 0.7 3.1 3 1 conjunctivitis 2.6694450393316e-05 0.000673389484751259 1.86976845309273 0.695652173913043 3.1 3 1 abnormal hepatocyte morphology 2.03235433269261e-20 9.1917843683143e-18 1.86450446533064 0.693693693693694 3.1 3 1 absent trabeculae carneae 0.00185926862578273 0.0209272882653147 1.86077918168363 0.692307692307692 3.1 3 1 abnormal enzyme/coenzyme level 3.69296580375368e-11 4.08277886081657e-09 1.85364975953158 0.689655172413793 3.1 3 1 oxidative stress 1.72337326122545e-16 4.32314891371178e-14 1.85159014868766 0.688888888888889 3.1 3 1 increased fatty acid level 1.08673162514102e-06 4.09582563263375e-05 1.84785710403305 0.6875 3.1 3 1 increased pancreatic beta cell number 0.000612982269005661 0.00858232174598057 1.84785710403305 0.6875 3.1 3 1 abnormal wound healing 0.000612982269005661 0.00858232174598057 1.84785710403305 0.6875 3.1 3 1 dystonia 0.000612982269005661 0.00858232174598057 1.84785710403305 0.6875 3.1 3 1 kidney degeneration 0.000612982269005661 0.00858232174598057 1.84785710403305 0.6875 3.1 3 1 decreased liver regeneration 0.000205004281173472 0.00344559560418251 1.83901568248265 0.684210526315789 3.1 3 1 increased circulating bilirubin level 6.84808921212508e-10 5.87400755695212e-08 1.82567014051979 0.679245283018868 3.1 3 1 increased triglyceride level 8.08104544753329e-06 0.000227136729386882 1.82385895982483 0.678571428571429 3.1 3 1 abnormal postnatal growth/weight/body size 2.78187026071665e-06 8.81516213188876e-05 1.82076242508828 0.67741935483871 3.1 3 1 pale kidney 2.78187026071665e-06 8.81516213188876e-05 1.82076242508828 0.67741935483871 3.1 3 1 increased bone ossification 0.000176416312023493 0.00301605206981745 1.79186143421386 0.666666666666667 3.1 3 1 decreased hepatocyte number 0.00157861993629829 0.0184791392543153 1.79186143421386 0.666666666666667 3.1 3 1 absent optic nerve 0.00483176059547269 0.043156209986493 1.79186143421386 0.666666666666667 3.1 3 1 loss of dopaminergic neurons 0.00483176059547269 0.043156209986493 1.79186143421386 0.666666666666667 3.1 3 1 decreased circulating ketone body level 0.00483176059547269 0.043156209986493 1.79186143421386 0.666666666666667 3.1 3 1 bowed ulna 0.00483176059547269 0.043156209986493 1.79186143421386 0.666666666666667 3.1 3 1 abnormal fatty acid level 0.00483176059547269 0.043156209986493 1.79186143421386 0.666666666666667 3.1 3 1 prenatal growth retardation 0.00483176059547269 0.043156209986493 1.79186143421386 0.666666666666667 3.1 3 1 increased hepatocyte apoptosis 2.91134949190005e-07 1.35364146936474e-05 1.79186143421386 0.666666666666667 3.1 3 1 increased circulating glycerol level 0.000524586393467804 0.00761001550425427 1.79186143421386 0.666666666666667 3.1 3 1 abnormal neutrophil morphology 0.000524586393467804 0.00761001550425427 1.79186143421386 0.666666666666667 3.1 3 1 abnormal pregnancy 0.000524586393467804 0.00761001550425427 1.79186143421386 0.666666666666667 3.1 3 1 thick tail 0.0151784077481363 0.100148202910943 1.79186143421386 0.666666666666667 3.1 3 1 decreased level of surface class I molecules 0.0151784077481363 0.100148202910943 1.79186143421386 0.666666666666667 3.1 3 1 abnormal postural reflex 0.0151784077481363 0.100148202910943 1.79186143421386 0.666666666666667 3.1 3 1 abnormal ovary physiology 0.0151784077481363 0.100148202910943 1.79186143421386 0.666666666666667 3.1 3 1 abnormal posterior eye segment morphology 0.0151784077481363 0.100148202910943 1.79186143421386 0.666666666666667 3.1 3 1 shortened ST segment 0.0151784077481363 0.100148202910943 1.79186143421386 0.666666666666667 3.1 3 1 fusion of atlas and occipital bones 0.0151784077481363 0.100148202910943 1.79186143421386 0.666666666666667 3.1 3 1 abnormal pulmonary alveolar system morphology 0.0151784077481363 0.100148202910943 1.79186143421386 0.666666666666667 3.1 3 1 increased myeloid cell number 0.0151784077481363 0.100148202910943 1.79186143421386 0.666666666666667 3.1 3 1 increased liver weight 3.40827450197027e-14 6.28006135085263e-12 1.77149937246143 0.659090909090909 3.1 3 1 liver fibrosis 2.51442423256263e-07 1.20281351509607e-05 1.77000946550394 0.658536585365854 3.1 3 1 decreased neuron apoptosis 7.22612565641879e-07 2.85317263021297e-05 1.76828431007947 0.657894736842105 3.1 3 1 thick pulmonary interalveolar septum 2.08213211007781e-06 6.90573816509141e-05 1.76626341372509 0.657142857142857 3.1 3 1 abnormal hematopoietic stem cell physiology 0.000149099604722584 0.00265867574729339 1.75290792477443 0.652173913043478 3.1 3 1 decreased myocardial infarction size 0.000440047643708758 0.00661400914637786 1.74706489835852 0.65 3.1 3 1 increased erythroid progenitor cell number 1.77101716273696e-06 6.01452705000032e-05 1.74343274680268 0.648648648648649 3.1 3 1 megacephaly 0.00395394149307926 0.0372554146364949 1.72786638299194 0.642857142857143 3.1 3 1 increased lactate dehydrogenase level 0.00395394149307926 0.0372554146364949 1.72786638299194 0.642857142857143 3.1 3 1 abnormal vascular endothelial cell migration 0.00395394149307926 0.0372554146364949 1.72786638299194 0.642857142857143 3.1 3 1 increased circulating growth hormone level 0.00395394149307926 0.0372554146364949 1.72786638299194 0.642857142857143 3.1 3 1 spina bifida occulta 0.00395394149307926 0.0372554146364949 1.72786638299194 0.642857142857143 3.1 3 1 spontaneous skin ulceration 0.000124328686238097 0.00234093618774663 1.72018697684531 0.64 3.1 3 1 increased liver glycogen level 0.000124328686238097 0.00234093618774663 1.72018697684531 0.64 3.1 3 1 prolonged PR interval 0.000363922084632398 0.00564022545497253 1.71041318720414 0.636363636363636 3.1 3 1 increased adenoma incidence 0.000363922084632398 0.00564022545497253 1.71041318720414 0.636363636363636 3.1 3 1 impaired myelopoiesis 0.012142693847295 0.0844893732731362 1.71041318720414 0.636363636363636 3.1 3 1 focal hepatic necrosis 0.012142693847295 0.0844893732731362 1.71041318720414 0.636363636363636 3.1 3 1 abnormal proximal-distal axis patterning 0.012142693847295 0.0844893732731362 1.71041318720414 0.636363636363636 3.1 3 1 fatigue 0.012142693847295 0.0844893732731362 1.71041318720414 0.636363636363636 3.1 3 1 abnormal radial glial cell morphology 0.012142693847295 0.0844893732731362 1.71041318720414 0.636363636363636 3.1 3 1 cyclopia 0.012142693847295 0.0844893732731362 1.71041318720414 0.636363636363636 3.1 3 1 abnormal palate development 0.012142693847295 0.0844893732731362 1.71041318720414 0.636363636363636 3.1 3 1 reduced sympathetic cervical ganglion size 0.012142693847295 0.0844893732731362 1.71041318720414 0.636363636363636 3.1 3 1 abnormal blood homeostasis 8.77372417251585e-16 2.07853703610792e-13 1.69755293767629 0.631578947368421 3.1 3 1 impaired branching involved in ureteric bud morphogenesis 3.56828218632855e-06 0.000109581505413485 1.69755293767629 0.631578947368421 3.1 3 1 kyphoscoliosis 0.00107244144311523 0.0134055180389404 1.69755293767629 0.631578947368421 3.1 3 1 increased malignant tumor incidence 0.00107244144311523 0.0134055180389404 1.69755293767629 0.631578947368421 3.1 3 1 abnormal blastocyst morphology 0.00107244144311523 0.0134055180389404 1.69755293767629 0.631578947368421 3.1 3 1 increased circulating VLDL cholesterol level 0.00107244144311523 0.0134055180389404 1.69755293767629 0.631578947368421 3.1 3 1 decreased liver glycogen level 0.00107244144311523 0.0134055180389404 1.69755293767629 0.631578947368421 3.1 3 1 embryonic lethality between implantation and somite formation, incomplete penetrance 0.00107244144311523 0.0134055180389404 1.69755293767629 0.631578947368421 3.1 3 1 abnormal body weight 0.000297840949597196 0.00477986685240661 1.6798700945755 0.625 3.1 3 1 vasculature congestion 0.00318801604845267 0.0315315702605408 1.6798700945755 0.625 3.1 3 1 bowed radius 0.00318801604845267 0.0315315702605408 1.6798700945755 0.625 3.1 3 1 increased heart left ventricle size 0.00318801604845267 0.0315315702605408 1.6798700945755 0.625 3.1 3 1 decreased fibroblast apoptosis 0.00318801604845267 0.0315315702605408 1.6798700945755 0.625 3.1 3 1 decreased adipocyte glucose uptake 0.00318801604845267 0.0315315702605408 1.6798700945755 0.625 3.1 3 1 enlarged pituitary gland 0.0383393465458265 0.185182766082997 1.6798700945755 0.625 3.1 3 1 absent eyelids 0.0383393465458265 0.185182766082997 1.6798700945755 0.625 3.1 3 1 abnormal erythrocyte cell number 0.0383393465458265 0.185182766082997 1.6798700945755 0.625 3.1 3 1 abnormal urination 0.0383393465458265 0.185182766082997 1.6798700945755 0.625 3.1 3 1 abnormal atrial thrombosis 0.0383393465458265 0.185182766082997 1.6798700945755 0.625 3.1 3 1 joint swelling 0.0383393465458265 0.185182766082997 1.6798700945755 0.625 3.1 3 1 short ureter 0.0383393465458265 0.185182766082997 1.6798700945755 0.625 3.1 3 1 abnormal soft palate morphology 0.0383393465458265 0.185182766082997 1.6798700945755 0.625 3.1 3 1 increased left ventricle systolic pressure 0.0383393465458265 0.185182766082997 1.6798700945755 0.625 3.1 3 1 abnormal miscarriage rate 0.0383393465458265 0.185182766082997 1.6798700945755 0.625 3.1 3 1 thin stria vascularis 0.0383393465458265 0.185182766082997 1.6798700945755 0.625 3.1 3 1 abnormal kidney epithelium morphology 0.0383393465458265 0.185182766082997 1.6798700945755 0.625 3.1 3 1 abnormal choroid pigmentation 0.0383393465458265 0.185182766082997 1.6798700945755 0.625 3.1 3 1 stomach epithelial hyperplasia 0.0383393465458265 0.185182766082997 1.6798700945755 0.625 3.1 3 1 abnormal olfactory bulb mitral cell layer morphology 0.0383393465458265 0.185182766082997 1.6798700945755 0.625 3.1 3 1 abnormal lateral plate mesoderm morphology 0.0383393465458265 0.185182766082997 1.6798700945755 0.625 3.1 3 1 decreased quadriceps weight 0.0383393465458265 0.185182766082997 1.6798700945755 0.625 3.1 3 1 abnormal hepatic vein morphology 0.0383393465458265 0.185182766082997 1.6798700945755 0.625 3.1 3 1 increased heart right ventricle size 0.0383393465458265 0.185182766082997 1.6798700945755 0.625 3.1 3 1 decreased alveolar lamellar body number 0.0383393465458265 0.185182766082997 1.6798700945755 0.625 3.1 3 1 abnormal pulmonary acinus morphology 0.0383393465458265 0.185182766082997 1.6798700945755 0.625 3.1 3 1 abnormal macrophage activation involved in immune response 0.0383393465458265 0.185182766082997 1.6798700945755 0.625 3.1 3 1 absent hypoglossal canal 0.0383393465458265 0.185182766082997 1.6798700945755 0.625 3.1 3 1 retropleural edema 0.0383393465458265 0.185182766082997 1.6798700945755 0.625 3.1 3 1 abnormal umbilical vein topology 0.0383393465458265 0.185182766082997 1.6798700945755 0.625 3.1 3 1 increased brain apoptosis 0.0383393465458265 0.185182766082997 1.6798700945755 0.625 3.1 3 1 abnormal metabolism 8.59041324096037e-07 3.28748506721368e-05 1.67240400526627 0.622222222222222 3.1 3 1 increased circulating free fatty acid level 8.12021538691464e-10 6.84713077116955e-08 1.66567400926923 0.619718309859155 3.1 3 1 increased muscle cell glucose uptake 0.000868448557697317 0.0115214175321177 1.66387133177002 0.619047619047619 3.1 3 1 hepatic necrosis 7.06987483500381e-07 2.81381018433152e-05 1.65842494443198 0.617021276595745 3.1 3 1 increased cellular sensitivity to gamma-irradiation 7.06987483500381e-07 2.81381018433152e-05 1.65842494443198 0.617021276595745 3.1 3 1 absent common myeloid progenitor cells 0.00958774774697661 0.0701456544723656 1.65402593927434 0.615384615384615 3.1 3 1 abnormal grip strength 0.00958774774697661 0.0701456544723656 1.65402593927434 0.615384615384615 3.1 3 1 abnormal pulmonary alveolus epithelial cell morphology 0.00958774774697661 0.0701456544723656 1.65402593927434 0.615384615384615 3.1 3 1 abnormal telomere length 0.00958774774697661 0.0701456544723656 1.65402593927434 0.615384615384615 3.1 3 1 tracheoesophageal fistula 0.00958774774697661 0.0701456544723656 1.65402593927434 0.615384615384615 3.1 3 1 absent hypoglossal nerve 0.00958774774697661 0.0701456544723656 1.65402593927434 0.615384615384615 3.1 3 1 abnormal megakaryocyte differentiation 0.00254630747676619 0.0261654689596872 1.64253964802938 0.611111111111111 3.1 3 1 abnormal thymus cortex morphology 0.00254630747676619 0.0261654689596872 1.64253964802938 0.611111111111111 3.1 3 1 abnormal redox activity 0.00254630747676619 0.0261654689596872 1.64253964802938 0.611111111111111 3.1 3 1 abnormal glycogen homeostasis 0.00254630747676619 0.0261654689596872 1.64253964802938 0.611111111111111 3.1 3 1 abnormal metanephric mesenchyme morphology 0.00254630747676619 0.0261654689596872 1.64253964802938 0.611111111111111 3.1 3 1 enlarged liver 1.26489742291405e-12 1.85084255264629e-10 1.63955321230569 0.61 3.1 3 1 abnormal cell differentiation 5.61747799501067e-06 0.000162482285030105 1.63889765324439 0.609756097560976 3.1 3 1 decreased circulating HDL cholesterol level 1.06586888639763e-15 2.410317140831e-13 1.63787334221111 0.609375 3.1 3 1 decreased circulating cholesterol level 1.75366418274075e-21 9.69386589903917e-19 1.63030015735852 0.60655737704918 3.1 3 1 enlarged pericardium 5.53186669120117e-05 0.0012396863418345 1.62896494019442 0.606060606060606 3.1 3 1 decreased brown adipose tissue amount 5.53186669120117e-05 0.0012396863418345 1.62896494019442 0.606060606060606 3.1 3 1 decreased systemic arterial blood pressure 5.53186669120117e-05 0.0012396863418345 1.62896494019442 0.606060606060606 3.1 3 1 increased cardiomyocyte apoptosis 5.53186669120117e-05 0.0012396863418345 1.62896494019442 0.606060606060606 3.1 3 1 persistence of hyaloid vascular system 1.58297193261347e-05 0.000418898157699576 1.62682156527311 0.605263157894737 3.1 3 1 abnormal neural tube closure 2.48998268269926e-10 2.33729506536393e-08 1.61915189838602 0.602409638554217 3.1 3 1 increased B cell derived lymphoma incidence 1.07242104681633e-06 4.07274405184063e-05 1.61267529079248 0.6 3.1 3 1 small placenta 3.69385895429771e-06 0.000112054562790434 1.61267529079248 0.6 3.1 3 1 abnormal brain vasculature morphology 0.000156802544978861 0.00273716723252573 1.61267529079248 0.6 3.1 3 1 abnormal cellular respiration 0.000156802544978861 0.00273716723252573 1.61267529079248 0.6 3.1 3 1 abnormal keratinocyte physiology 0.000558109344635844 0.00797871836081415 1.61267529079248 0.6 3.1 3 1 abnormal preimplantation embryo development 0.000558109344635844 0.00797871836081415 1.61267529079248 0.6 3.1 3 1 placental labyrinth hypoplasia 0.00751692382825074 0.0571814924243845 1.61267529079248 0.6 3.1 3 1 abnormal bronchus morphology 0.00751692382825074 0.0571814924243845 1.61267529079248 0.6 3.1 3 1 abnormal pericyte morphology 0.00751692382825074 0.0571814924243845 1.61267529079248 0.6 3.1 3 1 abnormal trophectoderm morphology 0.00751692382825074 0.0571814924243845 1.61267529079248 0.6 3.1 3 1 immune system phenotype 0.00751692382825074 0.0571814924243845 1.61267529079248 0.6 3.1 3 1 heterochrony 0.00751692382825074 0.0571814924243845 1.61267529079248 0.6 3.1 3 1 abnormal trachea morphology 0.00202103214222494 0.0221956620476139 1.61267529079248 0.6 3.1 3 1 absent placental labyrinth 0.00202103214222494 0.0221956620476139 1.61267529079248 0.6 3.1 3 1 abnormal optic stalk morphology 0.00202103214222494 0.0221956620476139 1.61267529079248 0.6 3.1 3 1 jaundice 0.0293054536109822 0.150303744035708 1.61267529079248 0.6 3.1 3 1 small petrosal ganglion 0.0293054536109822 0.150303744035708 1.61267529079248 0.6 3.1 3 1 enlarged testis 0.0293054536109822 0.150303744035708 1.61267529079248 0.6 3.1 3 1 abnormal mammary gland physiology 0.0293054536109822 0.150303744035708 1.61267529079248 0.6 3.1 3 1 rickets 0.0293054536109822 0.150303744035708 1.61267529079248 0.6 3.1 3 1 increased atrioventricular cushion size 0.0293054536109822 0.150303744035708 1.61267529079248 0.6 3.1 3 1 abnormal hindlimb zeugopod morphology 0.0293054536109822 0.150303744035708 1.61267529079248 0.6 3.1 3 1 abnormal plasma membrane morphology 0.0293054536109822 0.150303744035708 1.61267529079248 0.6 3.1 3 1 abnormal placental transport 0.0293054536109822 0.150303744035708 1.61267529079248 0.6 3.1 3 1 osteosclerosis 0.0293054536109822 0.150303744035708 1.61267529079248 0.6 3.1 3 1 tachypnea 0.0293054536109822 0.150303744035708 1.61267529079248 0.6 3.1 3 1 vascular smooth muscle hyperplasia 0.0293054536109822 0.150303744035708 1.61267529079248 0.6 3.1 3 1 abnormal developmental vascular remodeling 0.0293054536109822 0.150303744035708 1.61267529079248 0.6 3.1 3 1 increased serotonin level 0.0293054536109822 0.150303744035708 1.61267529079248 0.6 3.1 3 1 abnormal vibrissa follicle morphology 0.0293054536109822 0.150303744035708 1.61267529079248 0.6 3.1 3 1 thick aortic valve cusps 0.0293054536109822 0.150303744035708 1.61267529079248 0.6 3.1 3 1 abnormal adaptive thermogenesis 0.0293054536109822 0.150303744035708 1.61267529079248 0.6 3.1 3 1 kidney cysts 5.19461897658788e-09 3.6398914659894e-07 1.59814668456912 0.594594594594595 3.1 3 1 increased fibroblast apoptosis 0.000125484932929786 0.00234694564408153 1.59587658984672 0.59375 3.1 3 1 abnormal atrioventricular cushion morphology 0.000444376344143239 0.00663895589223007 1.59276571930121 0.592592592592593 3.1 3 1 abnormal type II pneumocyte morphology 0.000444376344143239 0.00663895589223007 1.59276571930121 0.592592592592593 3.1 3 1 increased skin papilloma incidence 0.00159720901879108 0.0185672773881877 1.58824081668956 0.590909090909091 3.1 3 1 increased kidney weight 1.92846369056027e-06 6.46413525416603e-05 1.58105420665929 0.588235294117647 3.1 3 1 abnormal spleen red pulp morphology 0.000100118105084439 0.00198441264061786 1.58105420665929 0.588235294117647 3.1 3 1 abnormal adipose tissue morphology 0.00586973717596368 0.0482839004893411 1.58105420665929 0.588235294117647 3.1 3 1 abnormal dorsal-ventral axis patterning 0.00586973717596368 0.0482839004893411 1.58105420665929 0.588235294117647 3.1 3 1 abnormal cranial suture morphology 0.00586973717596368 0.0482839004893411 1.58105420665929 0.588235294117647 3.1 3 1 decreased body fat mass 0.00586973717596368 0.0482839004893411 1.58105420665929 0.588235294117647 3.1 3 1 abnormal cell cytoskeleton morphology 0.00586973717596368 0.0482839004893411 1.58105420665929 0.588235294117647 3.1 3 1 increased circulating aspartate transaminase level 1.32704957655843e-07 6.66875923573553e-06 1.57854459680745 0.587301587301587 3.1 3 1 embryonic lethality between implantation and placentation, complete penetrance 6.63167582597197e-06 0.000189612570311555 1.57761713229699 0.58695652173913 3.1 3 1 polychromatophilia 0.000352713968592696 0.00555301263844513 1.57560229560185 0.586206896551724 3.1 3 1 palatal shelves fail to meet at midline 2.29167782060438e-05 0.000587685420490039 1.57334174711461 0.585365853658537 3.1 3 1 liver inflammation 6.40824773651724e-13 9.66091893611311e-11 1.56787875493713 0.583333333333333 3.1 3 1 abnormal adrenal gland morphology 0.00125843959867832 0.0154205344911937 1.56787875493713 0.583333333333333 3.1 3 1 decreased body height 0.00125843959867832 0.0154205344911937 1.56787875493713 0.583333333333333 3.1 3 1 hemolytic anemia 0.00125843959867832 0.0154205344911937 1.56787875493713 0.583333333333333 3.1 3 1 increased hemangiosarcoma incidence 0.00125843959867832 0.0154205344911937 1.56787875493713 0.583333333333333 3.1 3 1 abnormal mineral level 0.0223780003998462 0.123153265474817 1.56787875493713 0.583333333333333 3.1 3 1 abnormal rectum morphology 0.0223780003998462 0.123153265474817 1.56787875493713 0.583333333333333 3.1 3 1 myocarditis 0.0223780003998462 0.123153265474817 1.56787875493713 0.583333333333333 3.1 3 1 decreased synaptic depression 0.0223780003998462 0.123153265474817 1.56787875493713 0.583333333333333 3.1 3 1 abnormal gastrocnemius morphology 0.0223780003998462 0.123153265474817 1.56787875493713 0.583333333333333 3.1 3 1 abnormal nucleotide metabolism 0.0223780003998462 0.123153265474817 1.56787875493713 0.583333333333333 3.1 3 1 decreased left ventricle systolic pressure 0.0223780003998462 0.123153265474817 1.56787875493713 0.583333333333333 3.1 3 1 decreased mammary gland epithelial cell proliferation 0.0223780003998462 0.123153265474817 1.56787875493713 0.583333333333333 3.1 3 1 abnormal liver morphology 2.67357378498985e-18 7.82413504724969e-16 1.56162225551599 0.581005586592179 3.1 3 1 abnormal mitochondrial ATP synthesis coupled electron transport 0.000279278864247228 0.00451107905724013 1.56065350721853 0.580645161290323 3.1 3 1 increased circulating triglyceride level 5.763705030182e-15 1.10286278942906e-12 1.55706579800653 0.579310344827586 3.1 3 1 abnormal nasal septum morphology 0.00457287327303628 0.0416352588652935 1.55609019286993 0.578947368421053 3.1 3 1 increased liver adenoma incidence 0.00457287327303628 0.0416352588652935 1.55609019286993 0.578947368421053 3.1 3 1 abnormal myocardial trabeculae morphology 1.45442130146326e-05 0.000393247063846724 1.55294657631868 0.577777777777778 3.1 3 1 abnormal xiphoid process morphology 0.000989372628306067 0.0127143342122121 1.55064931806969 0.576923076923077 3.1 3 1 abnormal erythrocyte osmotic lysis 0.000989372628306067 0.0127143342122121 1.55064931806969 0.576923076923077 3.1 3 1 insulin resistance 1.7274025070768e-13 2.86460915756903e-11 1.5475166931847 0.575757575757576 3.1 3 1 abnormal skeleton physiology 0.000220710579668194 0.00366011711283089 1.5475166931847 0.575757575757576 3.1 3 1 abnormal apoptosis 2.68746622445313e-06 8.625899655906e-05 1.54299179057305 0.574074074074074 3.1 3 1 abnormal vitelline vasculature morphology 8.04119745737555e-12 1.05276203553798e-09 1.5425589738015 0.573913043478261 3.1 3 1 abnormal erythrocyte physiology 0.00355781025492842 0.0340386654197479 1.53588122932617 0.571428571428571 3.1 3 1 abnormal embryonic/fetal subventricular zone morphology 0.00355781025492842 0.0340386654197479 1.53588122932617 0.571428571428571 3.1 3 1 complete atrioventricular septal defect 0.00355781025492842 0.0340386654197479 1.53588122932617 0.571428571428571 3.1 3 1 organ of Corti degeneration 9.17514696814962e-06 0.000256440203182833 1.53588122932617 0.571428571428571 3.1 3 1 abnormal dermal layer morphology 0.000174160247637959 0.00299011396323918 1.53588122932617 0.571428571428571 3.1 3 1 increased carcinoma incidence 0.000174160247637959 0.00299011396323918 1.53588122932617 0.571428571428571 3.1 3 1 absent otoliths 0.0170994894188397 0.109767690140294 1.53588122932617 0.571428571428571 3.1 3 1 abnormal sagittal suture morphology 0.0170994894188397 0.109767690140294 1.53588122932617 0.571428571428571 3.1 3 1 abnormal pancreas development 0.0170994894188397 0.109767690140294 1.53588122932617 0.571428571428571 3.1 3 1 abnormal maternal decidual layer morphology 0.0170994894188397 0.109767690140294 1.53588122932617 0.571428571428571 3.1 3 1 decreased tongue size 0.0170994894188397 0.109767690140294 1.53588122932617 0.571428571428571 3.1 3 1 increased stomach tumor incidence 0.0170994894188397 0.109767690140294 1.53588122932617 0.571428571428571 3.1 3 1 pulmonary alveolar hemorrhage 0.0170994894188397 0.109767690140294 1.53588122932617 0.571428571428571 3.1 3 1 multiple persisting craniopharyngeal ducts 0.0170994894188397 0.109767690140294 1.53588122932617 0.571428571428571 3.1 3 1 abnormal visceral yolk sac morphology 2.2260206389903e-08 1.36721638012059e-06 1.53102084568906 0.569620253164557 3.1 3 1 malocclusion 0.000137261024028081 0.00249223939613031 1.52550365345234 0.567567567567568 3.1 3 1 abnormal circulating insulin level 0.00276606324049087 0.0278566085454293 1.51918686813784 0.565217391304348 3.1 3 1 decreased circulating LDL cholesterol level 8.46367488951535e-07 3.26409167250689e-05 1.51188308511795 0.5625 3.1 3 1 kidney cortex cysts 0.000477013918798228 0.00704197105644268 1.51188308511795 0.5625 3.1 3 1 absent mandible 0.0130826624022768 0.0886733589255141 1.51188308511795 0.5625 3.1 3 1 abnormal mouth morphology 0.0130826624022768 0.0886733589255141 1.51188308511795 0.5625 3.1 3 1 abnormal intestinal absorption 0.0130826624022768 0.0886733589255141 1.51188308511795 0.5625 3.1 3 1 abnormal olfaction 0.0130826624022768 0.0886733589255141 1.51188308511795 0.5625 3.1 3 1 small pancreas 0.0130826624022768 0.0886733589255141 1.51188308511795 0.5625 3.1 3 1 sepsis 0.0130826624022768 0.0886733589255141 1.51188308511795 0.5625 3.1 3 1 blepharitis 0.0130826624022768 0.0886733589255141 1.51188308511795 0.5625 3.1 3 1 decreased creatinine clearance 0.0130826624022768 0.0886733589255141 1.51188308511795 0.5625 3.1 3 1 increased hepatocellular carcinoma incidence 3.60636740418067e-06 0.00011007164316441 1.50893594460115 0.56140350877193 3.1 3 1 abnormal glucose homeostasis 1.73794931204494e-16 4.32314891371178e-14 1.50634505183913 0.56043956043956 3.1 3 1 abnormal circulating protein level 1.54630592768858e-05 0.000413595268293046 1.50516360473965 0.56 3.1 3 1 mandible hypoplasia 0.00214976901291421 0.0230497862914832 1.50516360473965 0.56 3.1 3 1 hypoglycemia 4.46362685205547e-09 3.21833965057623e-07 1.50285152546969 0.559139784946237 3.1 3 1 abnormal placenta morphology 7.8674776373681e-08 4.25442404846808e-06 1.4969981602293 0.556962025316456 3.1 3 1 abnormal small intestine morphology 9.60549092374247e-06 0.000266968253327479 1.49321786184489 0.555555555555556 3.1 3 1 decreased circulating fructosamine level 0.0016706179835096 0.0191505172072817 1.49321786184489 0.555555555555556 3.1 3 1 abnormal bone trabecula morphology 0.0016706179835096 0.0191505172072817 1.49321786184489 0.555555555555556 3.1 3 1 decreased susceptibility to hepatic steatosis 1.777156736382e-06 6.01452705000032e-05 1.49321786184489 0.555555555555556 3.1 3 1 delayed kidney development 0.0100240242999606 0.0720657816362773 1.49321786184489 0.555555555555556 3.1 3 1 abnormal white adipose tissue morphology 0.0100240242999606 0.0720657816362773 1.49321786184489 0.555555555555556 3.1 3 1 absent allantois 0.0100240242999606 0.0720657816362773 1.49321786184489 0.555555555555556 3.1 3 1 decreased cellular sensitivity to gamma-irradiation 0.0100240242999606 0.0720657816362773 1.49321786184489 0.555555555555556 3.1 3 1 decreased tumor latency 0.0100240242999606 0.0720657816362773 1.49321786184489 0.555555555555556 3.1 3 1 abnormal aerobic respiration 0.0100240242999606 0.0720657816362773 1.49321786184489 0.555555555555556 3.1 3 1 abnormal hypoglossal nerve topology 0.0100240242999606 0.0720657816362773 1.49321786184489 0.555555555555556 3.1 3 1 increased adipocyte glucose uptake 0.0100240242999606 0.0720657816362773 1.49321786184489 0.555555555555556 3.1 3 1 heart hyperplasia 0.0672905200429393 0.261363530258807 1.49321786184489 0.555555555555556 3.1 3 1 distorted hair follicle pattern 0.0672905200429393 0.261363530258807 1.49321786184489 0.555555555555556 3.1 3 1 synostosis 0.0672905200429393 0.261363530258807 1.49321786184489 0.555555555555556 3.1 3 1 small nodose ganglion 0.0672905200429393 0.261363530258807 1.49321786184489 0.555555555555556 3.1 3 1 dilated uterus 0.0672905200429393 0.261363530258807 1.49321786184489 0.555555555555556 3.1 3 1 abnormal ion homeostasis 0.0672905200429393 0.261363530258807 1.49321786184489 0.555555555555556 3.1 3 1 increased pheochromocytoma incidence 0.0672905200429393 0.261363530258807 1.49321786184489 0.555555555555556 3.1 3 1 abnormal thymus lobule morphology 0.0672905200429393 0.261363530258807 1.49321786184489 0.555555555555556 3.1 3 1 abnormal posterior semicircular canal morphology 0.0672905200429393 0.261363530258807 1.49321786184489 0.555555555555556 3.1 3 1 decreased circulating bicarbonate level 0.0672905200429393 0.261363530258807 1.49321786184489 0.555555555555556 3.1 3 1 enlarged otoliths 0.0672905200429393 0.261363530258807 1.49321786184489 0.555555555555556 3.1 3 1 biliary cyst 0.0672905200429393 0.261363530258807 1.49321786184489 0.555555555555556 3.1 3 1 pancreas cysts 0.0672905200429393 0.261363530258807 1.49321786184489 0.555555555555556 3.1 3 1 decreased fear-related response 0.0672905200429393 0.261363530258807 1.49321786184489 0.555555555555556 3.1 3 1 decreased cellular sensitivity to ionizing radiation 0.0672905200429393 0.261363530258807 1.49321786184489 0.555555555555556 3.1 3 1 abnormal stria vascularis vasculature morphology 0.0672905200429393 0.261363530258807 1.49321786184489 0.555555555555556 3.1 3 1 short frontal bone 0.0672905200429393 0.261363530258807 1.49321786184489 0.555555555555556 3.1 3 1 absent cochlear outer hair cells 0.0672905200429393 0.261363530258807 1.49321786184489 0.555555555555556 3.1 3 1 increased circulating progesterone level 0.0672905200429393 0.261363530258807 1.49321786184489 0.555555555555556 3.1 3 1 absent adrenal gland 0.0672905200429393 0.261363530258807 1.49321786184489 0.555555555555556 3.1 3 1 enhanced conditioned place preference behavior 0.0672905200429393 0.261363530258807 1.49321786184489 0.555555555555556 3.1 3 1 abnormal optic chiasm morphology 0.0672905200429393 0.261363530258807 1.49321786184489 0.555555555555556 3.1 3 1 multiflagellated sperm 0.0672905200429393 0.261363530258807 1.49321786184489 0.555555555555556 3.1 3 1 decreased transitional stage T1 B cell number 0.0672905200429393 0.261363530258807 1.49321786184489 0.555555555555556 3.1 3 1 abnormal cerebellar layer morphology 0.0672905200429393 0.261363530258807 1.49321786184489 0.555555555555556 3.1 3 1 abnormal incisor color 0.0672905200429393 0.261363530258807 1.49321786184489 0.555555555555556 3.1 3 1 abnormal telomere morphology 0.0672905200429393 0.261363530258807 1.49321786184489 0.555555555555556 3.1 3 1 prolonged RR interval 0.0672905200429393 0.261363530258807 1.49321786184489 0.555555555555556 3.1 3 1 abnormal pulmonary alveolar parenchyma morphology 0.0672905200429393 0.261363530258807 1.49321786184489 0.555555555555556 3.1 3 1 trigeminal neuroma 0.0672905200429393 0.261363530258807 1.49321786184489 0.555555555555556 3.1 3 1 symmetric azygos veins 0.0672905200429393 0.261363530258807 1.49321786184489 0.555555555555556 3.1 3 1 cerebellum atrophy 0.0672905200429393 0.261363530258807 1.49321786184489 0.555555555555556 3.1 3 1 adipose tissue inflammation 0.0672905200429393 0.261363530258807 1.49321786184489 0.555555555555556 3.1 3 1 pale liver 2.62013929781607e-07 1.24144695301285e-05 1.48918213789395 0.554054054054054 3.1 3 1 decreased white adipose tissue amount 1.10607791632161e-06 4.13739671706767e-05 1.48430312834134 0.552238805970149 3.1 3 1 abnormal microglial cell morphology 0.00129833339041433 0.0157158360518523 1.48291980762527 0.551724137931034 3.1 3 1 increased mortality induced by gamma-irradiation 0.00129833339041433 0.0157158360518523 1.48291980762527 0.551724137931034 3.1 3 1 decreased trophoblast giant cell number 0.00129833339041433 0.0157158360518523 1.48291980762527 0.551724137931034 3.1 3 1 increased T cell derived lymphoma incidence 3.23983294210972e-05 0.000778655501787241 1.48102832827881 0.551020408163265 3.1 3 1 abnormal pericardium morphology 0.00769179021069458 0.058244530134255 1.47828568322644 0.55 3.1 3 1 abnormal physiological neovascularization 0.00769179021069458 0.058244530134255 1.47828568322644 0.55 3.1 3 1 abnormal neuron proliferation 0.00769179021069458 0.058244530134255 1.47828568322644 0.55 3.1 3 1 abnormal ovary morphology 6.87396102594221e-07 2.8031111560707e-05 1.47639287185227 0.549295774647887 3.1 3 1 spina bifida 0.000139848471620727 0.00252998598659315 1.47188617810425 0.547619047619048 3.1 3 1 enlarged kidney 1.99582189073331e-05 0.000522590205599905 1.4706787243076 0.547169811320755 3.1 3 1 spleen hyperplasia 4.26691481122299e-07 1.87857532618003e-05 1.46932637605537 0.546666666666667 3.1 3 1 hyperglycemia 4.99164041210485e-08 2.82197852843428e-06 1.46606844617498 0.545454545454545 3.1 3 1 abnormal joint morphology 1.56597735844031e-05 0.000416616971028905 1.46606844617498 0.545454545454545 3.1 3 1 lethality, incomplete penetrance 0.000109355572300158 0.00211690261553808 1.46606844617498 0.545454545454545 3.1 3 1 abnormal abdominal fat pad morphology 0.00591053173829321 0.0482839004893411 1.46606844617498 0.545454545454545 3.1 3 1 abnormal vascular branching morphogenesis 0.00591053173829321 0.0482839004893411 1.46606844617498 0.545454545454545 3.1 3 1 abnormal limb posture 0.00591053173829321 0.0482839004893411 1.46606844617498 0.545454545454545 3.1 3 1 decreased circulating estradiol level 0.00591053173829321 0.0482839004893411 1.46606844617498 0.545454545454545 3.1 3 1 abnormal cerebral cortex pyramidal cell morphology 0.00591053173829321 0.0482839004893411 1.46606844617498 0.545454545454545 3.1 3 1 increased circulating creatine kinase level 0.00591053173829321 0.0482839004893411 1.46606844617498 0.545454545454545 3.1 3 1 premature suture closure 0.0499007653274069 0.219890440658857 1.46606844617498 0.545454545454545 3.1 3 1 abnormal sphenoid bone morphology 0.0499007653274069 0.219890440658857 1.46606844617498 0.545454545454545 3.1 3 1 abnormal food preference 0.0499007653274069 0.219890440658857 1.46606844617498 0.545454545454545 3.1 3 1 abnormal bronchiole morphology 0.0499007653274069 0.219890440658857 1.46606844617498 0.545454545454545 3.1 3 1 pharyngeal arch hypoplasia 0.0499007653274069 0.219890440658857 1.46606844617498 0.545454545454545 3.1 3 1 abnormal spinal cord ventral horn morphology 0.0499007653274069 0.219890440658857 1.46606844617498 0.545454545454545 3.1 3 1 abnormal Bruch membrane morphology 0.0499007653274069 0.219890440658857 1.46606844617498 0.545454545454545 3.1 3 1 abnormal superovulation 0.0499007653274069 0.219890440658857 1.46606844617498 0.545454545454545 3.1 3 1 palatal shelf hypoplasia 0.0499007653274069 0.219890440658857 1.46606844617498 0.545454545454545 3.1 3 1 abnormal palatal shelf elevation 0.0499007653274069 0.219890440658857 1.46606844617498 0.545454545454545 3.1 3 1 aorta dilation 0.0499007653274069 0.219890440658857 1.46606844617498 0.545454545454545 3.1 3 1 increased pancreatic beta cell proliferation 0.0499007653274069 0.219890440658857 1.46606844617498 0.545454545454545 3.1 3 1 chylous ascites 0.0499007653274069 0.219890440658857 1.46606844617498 0.545454545454545 3.1 3 1 hypolactation 0.0499007653274069 0.219890440658857 1.46606844617498 0.545454545454545 3.1 3 1 myeloid hyperplasia 0.000784577925754261 0.0105209573601818 1.46606844617498 0.545454545454545 3.1 3 1 abnormal myocardium layer morphology 2.6460789930332e-07 1.24190971606983e-05 1.46297547476955 0.544303797468354 3.1 3 1 embryonic lethality during organogenesis, incomplete penetrance 2.20546359665707e-18 6.85761337085559e-16 1.46075660397869 0.543478260869565 3.1 3 1 failure to gastrulate 8.55074660481027e-05 0.00177991482673352 1.46075660397869 0.543478260869565 3.1 3 1 increased red blood cell distribution width 0.00061013074727992 0.00858232174598057 1.45908716785986 0.542857142857143 3.1 3 1 abnormal lipid level 1.63964234843659e-07 8.15722068347203e-06 1.45723670854742 0.542168674698795 3.1 3 1 abnormal primitive streak formation 0.00454780027172388 0.0416352588652935 1.45588741529876 0.541666666666667 3.1 3 1 abnormal inner cell mass apoptosis 0.00454780027172388 0.0416352588652935 1.45588741529876 0.541666666666667 3.1 3 1 abnormal lung saccule morphology 0.00454780027172388 0.0416352588652935 1.45588741529876 0.541666666666667 3.1 3 1 abnormal respiratory electron transport chain 0.000474607027500056 0.00702729155301422 1.45286062233557 0.540540540540541 3.1 3 1 decreased circulating alkaline phosphatase level 5.22788639382156e-05 0.0011985592078001 1.45140776171323 0.54 3.1 3 1 increased insulin sensitivity 1.24526751137486e-11 1.47504901644998e-09 1.44727269686504 0.538461538461538 3.1 3 1 abnormal cornea morphology 5.37473264108869e-07 2.26604193978104e-05 1.44727269686504 0.538461538461538 3.1 3 1 abnormal heart ventricle morphology 5.37473264108869e-07 2.26604193978104e-05 1.44727269686504 0.538461538461538 3.1 3 1 abnormal kidney cortex morphology 0.00350356479495705 0.0337141873402541 1.44727269686504 0.538461538461538 3.1 3 1 decreased circulating glycerol level 0.00350356479495705 0.0337141873402541 1.44727269686504 0.538461538461538 3.1 3 1 abnormal Mullerian duct morphology 0.00350356479495705 0.0337141873402541 1.44727269686504 0.538461538461538 3.1 3 1 decreased bone resorption 0.00350356479495705 0.0337141873402541 1.44727269686504 0.538461538461538 3.1 3 1 increased thymocyte apoptosis 0.00350356479495705 0.0337141873402541 1.44727269686504 0.538461538461538 3.1 3 1 absent myocardial trabeculae 0.0372999618281941 0.185182766082997 1.44727269686504 0.538461538461538 3.1 3 1 short hair 0.0372999618281941 0.185182766082997 1.44727269686504 0.538461538461538 3.1 3 1 abnormal tail bud morphology 0.0372999618281941 0.185182766082997 1.44727269686504 0.538461538461538 3.1 3 1 abnormal otolith morphology 0.0372999618281941 0.185182766082997 1.44727269686504 0.538461538461538 3.1 3 1 axonal dystrophy 0.0372999618281941 0.185182766082997 1.44727269686504 0.538461538461538 3.1 3 1 abnormal vestibulocochlear ganglion morphology 0.0372999618281941 0.185182766082997 1.44727269686504 0.538461538461538 3.1 3 1 small interparietal bone 0.0372999618281941 0.185182766082997 1.44727269686504 0.538461538461538 3.1 3 1 orthokeratosis 0.0372999618281941 0.185182766082997 1.44727269686504 0.538461538461538 3.1 3 1 increased prostaglandin level 0.0372999618281941 0.185182766082997 1.44727269686504 0.538461538461538 3.1 3 1 thrombocytopenia 9.81782551803215e-12 1.19130931590756e-09 1.44584681243463 0.537931034482759 3.1 3 1 abnormal retinal pigment epithelium morphology 4.22235576748932e-07 1.87555535207673e-05 1.44468828133493 0.5375 3.1 3 1 abnormal cell adhesion 3.19673833682979e-05 0.000775793815889181 1.44344393311672 0.537037037037037 3.1 3 1 decreased platelet aggregation 3.19673833682979e-05 0.000775793815889181 1.44344393311672 0.537037037037037 3.1 3 1 microcephaly 2.85833331142911e-06 8.96532434943585e-05 1.44127984925898 0.536231884057971 3.1 3 1 abnormal stria vascularis morphology 0.00270216296821418 0.0274352260548276 1.43988865249328 0.535714285714286 3.1 3 1 small superior cervical ganglion 0.00270216296821418 0.0274352260548276 1.43988865249328 0.535714285714286 3.1 3 1 subcutaneous edema 0.00270216296821418 0.0274352260548276 1.43988865249328 0.535714285714286 3.1 3 1 decreased liver weight 2.24128450359841e-06 7.28783686627588e-05 1.43853664436888 0.535211267605634 3.1 3 1 increased circulating creatinine level 2.04622082889572e-07 9.98034178799627e-06 1.43765626698554 0.534883720930233 3.1 3 1 decreased bone marrow cell number 1.75741347104026e-06 6.01452705000032e-05 1.43594375207549 0.534246575342466 3.1 3 1 decreased percent body fat/body weight 1.75741347104026e-06 6.01452705000032e-05 1.43594375207549 0.534246575342466 3.1 3 1 trabecula carnea hypoplasia 0.000174298100369721 0.00299011396323918 1.43348914737109 0.533333333333333 3.1 3 1 liver hemorrhage 0.00208625060204036 0.0227113714335904 1.43348914737109 0.533333333333333 3.1 3 1 abnormal fat pad morphology 0.00208625060204036 0.0227113714335904 1.43348914737109 0.533333333333333 3.1 3 1 interdigital webbing 0.0280509929509414 0.147208533682419 1.43348914737109 0.533333333333333 3.1 3 1 abnormal epidermis stratum spinosum morphology 0.0280509929509414 0.147208533682419 1.43348914737109 0.533333333333333 3.1 3 1 abnormal respiratory system morphology 0.0280509929509414 0.147208533682419 1.43348914737109 0.533333333333333 3.1 3 1 delayed intramembranous bone ossification 0.0280509929509414 0.147208533682419 1.43348914737109 0.533333333333333 3.1 3 1 abnormal glial cell morphology 0.0280509929509414 0.147208533682419 1.43348914737109 0.533333333333333 3.1 3 1 abnormal ear development 0.0280509929509414 0.147208533682419 1.43348914737109 0.533333333333333 3.1 3 1 abnormal placenta size 0.0280509929509414 0.147208533682419 1.43348914737109 0.533333333333333 3.1 3 1 abnormal energy homeostasis 0.0280509929509414 0.147208533682419 1.43348914737109 0.533333333333333 3.1 3 1 abnormal cerebral aqueduct morphology 0.0280509929509414 0.147208533682419 1.43348914737109 0.533333333333333 3.1 3 1 absent chorion 0.0280509929509414 0.147208533682419 1.43348914737109 0.533333333333333 3.1 3 1 abnormal coronary vessel morphology 0.0280509929509414 0.147208533682419 1.43348914737109 0.533333333333333 3.1 3 1 increased respiratory quotient 0.000135786927666314 0.00247450536681286 1.42967667623447 0.531914893617021 3.1 3 1 abnormal urine homeostasis 6.11169791148816e-08 3.34128539666523e-06 1.42788958038917 0.53125 3.1 3 1 polydipsia 0.00161227413702454 0.0185672773881877 1.42788958038917 0.53125 3.1 3 1 failure of primitive streak formation 0.00161227413702454 0.0185672773881877 1.42788958038917 0.53125 3.1 3 1 abnormal heart atrium morphology 0.00161227413702454 0.0185672773881877 1.42788958038917 0.53125 3.1 3 1 abnormal embryonic hematopoiesis 0.00161227413702454 0.0185672773881877 1.42788958038917 0.53125 3.1 3 1 bradykinesia 0.00161227413702454 0.0185672773881877 1.42788958038917 0.53125 3.1 3 1 abnormal auditory brainstem response waveform shape 0.00161227413702454 0.0185672773881877 1.42788958038917 0.53125 3.1 3 1 increased neuron apoptosis 6.64306757882002e-07 2.73134390120906e-05 1.42685262354067 0.530864197530864 3.1 3 1 increased circulating LDL cholesterol level 0.000105815216673618 0.00208075376660573 1.42617542723144 0.530612244897959 3.1 3 1 decreased circulating creatinine level 0.000105815216673618 0.00208075376660573 1.42617542723144 0.530612244897959 3.1 3 1 abnormal cell cycle 3.50583462801455e-09 2.60321302602573e-07 1.4256984454832 0.530434782608696 3.1 3 1 abnormal extraembryonic tissue morphology 2.95881430401579e-08 1.79513428810714e-06 1.42294878599336 0.529411764705882 3.1 3 1 abnormal lung development 4.0844846156155e-07 1.83065864528713e-05 1.42294878599336 0.529411764705882 3.1 3 1 failure of chorioallantoic fusion 8.24820288312654e-05 0.0017366857814387 1.42294878599336 0.529411764705882 3.1 3 1 enlarged liver sinusoidal spaces 0.00124708441381924 0.0154205344911937 1.42294878599336 0.529411764705882 3.1 3 1 abnormal interatrial septum morphology 0.0211972032818791 0.118224312026175 1.42294878599336 0.529411764705882 3.1 3 1 aminoaciduria 0.0211972032818791 0.118224312026175 1.42294878599336 0.529411764705882 3.1 3 1 increased hepatoma incidence 0.0211972032818791 0.118224312026175 1.42294878599336 0.529411764705882 3.1 3 1 abnormal ductus venosus valve morphology 0.0211972032818791 0.118224312026175 1.42294878599336 0.529411764705882 3.1 3 1 prenatal lethality, complete penetrance 7.26346671344722e-20 2.63548116183696e-17 1.42124261238905 0.528776978417266 3.1 3 1 abnormal enzyme/coenzyme activity 7.30643021323016e-12 9.8241865704919e-10 1.42093470420144 0.528662420382166 3.1 3 1 extramedullary hematopoiesis 1.8240776273376e-08 1.1487071134183e-06 1.41996566484872 0.528301886792453 3.1 3 1 abnormal placenta development 6.43113330123759e-05 0.00142199502994031 1.41996566484872 0.528301886792453 3.1 3 1 increased sensitivity to induced morbidity/mortality 1.63466442926534e-13 2.80429501227417e-11 1.41693390585933 0.527173913043478 3.1 3 1 enlarged adrenal glands 0.0160808587743209 0.104578133859146 1.41462744806358 0.526315789473684 3.1 3 1 shiny skin 0.0160808587743209 0.104578133859146 1.41462744806358 0.526315789473684 3.1 3 1 decreased susceptibility to weight gain 0.0160808587743209 0.104578133859146 1.41462744806358 0.526315789473684 3.1 3 1 small liver 1.68220227894969e-06 5.85241701942288e-05 1.41281382313016 0.525641025641026 3.1 3 1 increased circulating insulin level 8.888400101528e-12 1.1338407821821e-09 1.41109087944342 0.525 3.1 3 1 abnormal pancreatic beta cell morphology 0.00057981502431076 0.0082652714783554 1.41109087944342 0.525 3.1 3 1 enlarged spleen 6.64115502781644e-20 2.63548116183696e-17 1.40922435711611 0.524305555555556 3.1 3 1 disheveled coat 0.000449793628426434 0.00669977036353745 1.40789112688232 0.523809523809524 3.1 3 1 abnormal eye pigmentation 0.0122391681620373 0.0847575475253363 1.40789112688232 0.523809523809524 3.1 3 1 absent segment of posterior cerebral artery 0.0122391681620373 0.0847575475253363 1.40789112688232 0.523809523809524 3.1 3 1 abnormal astrocyte morphology 0.000349139012905731 0.00551417964827306 1.40498226091769 0.522727272727273 3.1 3 1 cochlear hair cell degeneration 0.000349139012905731 0.00551417964827306 1.40498226091769 0.522727272727273 3.1 3 1 decreased sensitivity to induced morbidity/mortality 0.000349139012905731 0.00551417964827306 1.40498226091769 0.522727272727273 3.1 3 1 delayed wound healing 0.000271160610538759 0.00440857528572001 1.40232633981955 0.521739130434783 3.1 3 1 hypotension 0.00934086100862304 0.0690501983921242 1.40232633981955 0.521739130434783 3.1 3 1 abnormal palatal shelf fusion at midline 0.00934086100862304 0.0690501983921242 1.40232633981955 0.521739130434783 3.1 3 1 decreased hematocrit 1.44391318590005e-10 1.46601389792914e-08 1.39912468150946 0.520547945205479 3.1 3 1 abnormal primitive streak morphology 0.00714566746876769 0.0551158072203399 1.39765191868681 0.52 3.1 3 1 abnormal egg cylinder morphology 0.00714566746876769 0.0551158072203399 1.39765191868681 0.52 3.1 3 1 abnormal placenta vasculature 0.000127412760891827 0.00237407672448254 1.39558438626272 0.519230769230769 3.1 3 1 abnormal chondrocyte morphology 9.91432787829203e-05 0.00197295124778011 1.39367000438856 0.518518518518518 3.1 3 1 wrinkled skin 0.00547750751497737 0.0464235091771932 1.39367000438856 0.518518518518518 3.1 3 1 abnormal eye muscle morphology 0.00547750751497737 0.0464235091771932 1.39367000438856 0.518518518518518 3.1 3 1 pale yolk sac 1.57946849589834e-06 5.53370124443256e-05 1.39247063261198 0.518072289156627 3.1 3 1 cardiac fibrosis 1.23533937084649e-06 4.55245434811948e-05 1.39132770186018 0.517647058823529 3.1 3 1 blood in lymph vessels 0.00420626608728546 0.0390413690004574 1.39023731964869 0.517241379310345 3.1 3 1 increased osteoblast cell number 0.00249170136149922 0.0259878705942528 1.38462019916526 0.515151515151515 3.1 3 1 decreased sensitivity to xenobiotic induced morbidity/mortality 0.00249170136149922 0.0259878705942528 1.38462019916526 0.515151515151515 3.1 3 1 decreased bone mineralization 0.00192150594309616 0.0215789888643417 1.38229310639355 0.514285714285714 3.1 3 1 abnormal skeleton morphology 3.13820930304942e-08 1.8810350942977e-06 1.37895423415589 0.51304347826087 3.1 3 1 abnormal mammary gland development 0.000886807326232449 0.0117025635225635 1.37667402872529 0.51219512195122 3.1 3 1 increased bone trabecula number 0.000886807326232449 0.0117025635225635 1.37667402872529 0.51219512195122 3.1 3 1 abnormal double-strand DNA break repair 0.000686551300255931 0.00940934633270869 1.37514947276878 0.511627906976744 3.1 3 1 decreased hemoglobin content 1.31901918358214e-09 1.04160641878114e-07 1.37248960918509 0.51063829787234 3.1 3 1 cleft secondary palate 6.97618889681146e-07 2.81381018433152e-05 1.37248960918509 0.51063829787234 3.1 3 1 distended abdomen 0.000248397071574905 0.00409197162610977 1.37024697910472 0.509803921568627 3.1 3 1 decreased erythrocyte cell number 1.88317845409082e-10 1.80169477098112e-08 1.36957561850741 0.509554140127389 3.1 3 1 absent vitelline blood vessels 0.000116585776096313 0.00221379479419526 1.36747319979479 0.508771929824561 3.1 3 1 abnormal nervous system morphology 7.50197011075217e-06 0.000212058530119273 1.36090741839028 0.506329113924051 3.1 3 1 increased circulating cholesterol level 3.13975309981231e-11 3.55006174353778e-09 1.35916762197472 0.505681818181818 3.1 3 1 lethality throughout fetal growth and development, complete penetrance 1.58408052063659e-11 1.83274432329465e-09 1.3438960756604 0.5 3.1 3 1 abnormal neural tube morphology 4.77876058951937e-10 4.17093577769454e-08 1.3438960756604 0.5 3.1 3 1 impaired balance 7.33213282231756e-07 2.87223313315196e-05 1.3438960756604 0.5 3.1 3 1 decreased circulating alanine transaminase level 4.937922495906e-05 0.00114261229847127 1.3438960756604 0.5 3.1 3 1 abnormal osteoclast physiology 8.14489346152909e-05 0.00173166004150031 1.3438960756604 0.5 3.1 3 1 abnormal incisor morphology 0.000134560914915998 0.00246117849892312 1.3438960756604 0.5 3.1 3 1 cochlear ganglion degeneration 0.000173071336892211 0.00299011396323918 1.3438960756604 0.5 3.1 3 1 decreased kidney weight 0.000369381382257981 0.00568938816326147 1.3438960756604 0.5 3.1 3 1 oligodactyly 0.00061413196815459 0.00858232174598057 1.3438960756604 0.5 3.1 3 1 abnormal myelopoiesis 0.00102396358760613 0.0130286927067532 1.3438960756604 0.5 3.1 3 1 abnormal cytotoxic T cell physiology 0.00132382102403845 0.0159854601810469 1.3438960756604 0.5 3.1 3 1 abnormal frontal bone morphology 0.00221901472958979 0.0236901250637536 1.3438960756604 0.5 3.1 3 1 incomplete somite formation 0.00221901472958979 0.0236901250637536 1.3438960756604 0.5 3.1 3 1 abnormal uterus morphology 0.00287761141502591 0.0287472224693854 1.3438960756604 0.5 3.1 3 1 impaired wound healing 0.00287761141502591 0.0287472224693854 1.3438960756604 0.5 3.1 3 1 abnormal pharyngeal arch morphology 0.00287761141502591 0.0287472224693854 1.3438960756604 0.5 3.1 3 1 abnormal endoderm development 0.00373631830917918 0.0356095471037671 1.3438960756604 0.5 3.1 3 1 abnormal brown adipose tissue morphology 0.00373631830917918 0.0356095471037671 1.3438960756604 0.5 3.1 3 1 abnormal spongiotrophoblast layer morphology 0.00485800510641312 0.0433128591476797 1.3438960756604 0.5 3.1 3 1 abnormal heart tube morphology 0.00632628157253053 0.0510101309940671 1.3438960756604 0.5 3.1 3 1 abnormal lactation 0.00632628157253053 0.0510101309940671 1.3438960756604 0.5 3.1 3 1 abnormal microglial cell physiology 0.00632628157253053 0.0510101309940671 1.3438960756604 0.5 3.1 3 1 abnormal leukocyte cell number 0.0107877701425783 0.0762345972433626 1.3438960756604 0.5 3.1 3 1 abnormal Schwann cell morphology 0.0107877701425783 0.0762345972433626 1.3438960756604 0.5 3.1 3 1 increased leukemia incidence 0.0107877701425783 0.0762345972433626 1.3438960756604 0.5 3.1 3 1 decreased metastatic potential 0.0141339217455222 0.094511103069856 1.3438960756604 0.5 3.1 3 1 ocular hypertelorism 0.0141339217455222 0.094511103069856 1.3438960756604 0.5 3.1 3 1 abnormal vasodilation 0.0141339217455222 0.094511103069856 1.3438960756604 0.5 3.1 3 1 increased body temperature 0.0141339217455222 0.094511103069856 1.3438960756604 0.5 3.1 3 1 abnormal truncus arteriosus septation 0.0141339217455222 0.094511103069856 1.3438960756604 0.5 3.1 3 1 abnormal germ layer development 0.0185678045857814 0.115468534767828 1.3438960756604 0.5 3.1 3 1 aphakia 0.0185678045857814 0.115468534767828 1.3438960756604 0.5 3.1 3 1 abnormal cochlear sensory epithelium morphology 0.0185678045857814 0.115468534767828 1.3438960756604 0.5 3.1 3 1 parakeratosis 0.0185678045857814 0.115468534767828 1.3438960756604 0.5 3.1 3 1 cleft upper lip 0.0185678045857814 0.115468534767828 1.3438960756604 0.5 3.1 3 1 rough coat 0.0185678045857814 0.115468534767828 1.3438960756604 0.5 3.1 3 1 increased mammary gland tumor incidence 0.0185678045857814 0.115468534767828 1.3438960756604 0.5 3.1 3 1 increased bone volume 0.0185678045857814 0.115468534767828 1.3438960756604 0.5 3.1 3 1 increased circulating renin level 0.0323703822637975 0.163827723054316 1.3438960756604 0.5 3.1 3 1 decreased pulmonary respiratory rate 0.0323703822637975 0.163827723054316 1.3438960756604 0.5 3.1 3 1 increased gastrointestinal tumor incidence 0.0323703822637975 0.163827723054316 1.3438960756604 0.5 3.1 3 1 increased effector memory CD4-positive, alpha-beta T cell number 0.0323703822637975 0.163827723054316 1.3438960756604 0.5 3.1 3 1 poor circulation 0.043019323499606 0.201526491911996 1.3438960756604 0.5 3.1 3 1 abnormal extraembryonic endoderm formation 0.043019323499606 0.201526491911996 1.3438960756604 0.5 3.1 3 1 abnormal meiosis 0.043019323499606 0.201526491911996 1.3438960756604 0.5 3.1 3 1 abnormal epididymis epithelium morphology 0.043019323499606 0.201526491911996 1.3438960756604 0.5 3.1 3 1 decreased circulating triiodothyronine level 0.043019323499606 0.201526491911996 1.3438960756604 0.5 3.1 3 1 dilated respiratory conducting tubes 0.043019323499606 0.201526491911996 1.3438960756604 0.5 3.1 3 1 abnormal pulmonary alveolus wall morphology 0.043019323499606 0.201526491911996 1.3438960756604 0.5 3.1 3 1 amyloidosis 0.0774235302549675 0.273761238819093 1.3438960756604 0.5 3.1 3 1 impaired embryo implantation 0.0774235302549675 0.273761238819093 1.3438960756604 0.5 3.1 3 1 interstitial pneumonia 0.0774235302549675 0.273761238819093 1.3438960756604 0.5 3.1 3 1 altered tumor susceptibility 0.0774235302549675 0.273761238819093 1.3438960756604 0.5 3.1 3 1 small intestinal inflammation 0.0774235302549675 0.273761238819093 1.3438960756604 0.5 3.1 3 1 increased osteosarcoma incidence 0.0774235302549675 0.273761238819093 1.3438960756604 0.5 3.1 3 1 abnormal rostral-caudal body axis extension 0.0774235302549675 0.273761238819093 1.3438960756604 0.5 3.1 3 1 pale placenta 0.0774235302549675 0.273761238819093 1.3438960756604 0.5 3.1 3 1 small parietal bone 0.0774235302549675 0.273761238819093 1.3438960756604 0.5 3.1 3 1 hemoperitoneum 0.0774235302549675 0.273761238819093 1.3438960756604 0.5 3.1 3 1 impaired behavioral response to cocaine 0.0774235302549675 0.273761238819093 1.3438960756604 0.5 3.1 3 1 decreased prostaglandin level 0.0774235302549675 0.273761238819093 1.3438960756604 0.5 3.1 3 1 decreased red blood cell distribution width 0.0774235302549675 0.273761238819093 1.3438960756604 0.5 3.1 3 1 increased fibrosarcoma incidence 0.0774235302549675 0.273761238819093 1.3438960756604 0.5 3.1 3 1 increased skeletal muscle glycogen level 0.0774235302549675 0.273761238819093 1.3438960756604 0.5 3.1 3 1 abnormal pulmonary valve cusp morphology 0.0774235302549675 0.273761238819093 1.3438960756604 0.5 3.1 3 1 abnormal colon goblet cell morphology 0.0774235302549675 0.273761238819093 1.3438960756604 0.5 3.1 3 1 increased oxygen consumption 5.27423840446733e-06 0.000154349035660147 1.3438960756604 0.5 3.1 3 1 thick epidermis 3.84686814124559e-05 0.000907022227615962 1.3438960756604 0.5 3.1 3 1 atrial septal defect 0.000792693868757102 0.0106012150458779 1.3438960756604 0.5 3.1 3 1 abnormal somite shape 0.00825285206174056 0.0614639805496397 1.3438960756604 0.5 3.1 3 1 failure of blastocyst to hatch from the zona pellucida 0.00825285206174056 0.0614639805496397 1.3438960756604 0.5 3.1 3 1 decreased circulating progesterone level 0.00825285206174056 0.0614639805496397 1.3438960756604 0.5 3.1 3 1 corneal vascularization 0.00825285206174056 0.0614639805496397 1.3438960756604 0.5 3.1 3 1 abnormal renal tubule epithelium morphology 0.00825285206174056 0.0614639805496397 1.3438960756604 0.5 3.1 3 1 abnormal cell proliferation 0.0244699273379472 0.133046872684467 1.3438960756604 0.5 3.1 3 1 abnormal circulating enzyme level 0.0244699273379472 0.133046872684467 1.3438960756604 0.5 3.1 3 1 increased mammary adenocarcinoma incidence 0.0244699273379472 0.133046872684467 1.3438960756604 0.5 3.1 3 1 abnormal hearing physiology 0.0244699273379472 0.133046872684467 1.3438960756604 0.5 3.1 3 1 dilated vasculature 0.0244699273379472 0.133046872684467 1.3438960756604 0.5 3.1 3 1 midline facial cleft 0.0575004342375482 0.246183012333737 1.3438960756604 0.5 3.1 3 1 abnormal kidney blood vessel morphology 0.0575004342375482 0.246183012333737 1.3438960756604 0.5 3.1 3 1 abnormal placing response 0.0575004342375482 0.246183012333737 1.3438960756604 0.5 3.1 3 1 abnormal adrenal gland secretion 0.0575004342375482 0.246183012333737 1.3438960756604 0.5 3.1 3 1 abnormal ventral body wall morphology 0.0575004342375482 0.246183012333737 1.3438960756604 0.5 3.1 3 1 failure of zygotic cell division 0.0575004342375482 0.246183012333737 1.3438960756604 0.5 3.1 3 1 absent olfactory bulb 0.0575004342375482 0.246183012333737 1.3438960756604 0.5 3.1 3 1 abnormal decidualization 0.0575004342375482 0.246183012333737 1.3438960756604 0.5 3.1 3 1 skeletal muscle necrosis 0.0575004342375482 0.246183012333737 1.3438960756604 0.5 3.1 3 1 enlarged stomach 0.0575004342375482 0.246183012333737 1.3438960756604 0.5 3.1 3 1 lysosomal protein accumulation 0.0575004342375482 0.246183012333737 1.3438960756604 0.5 3.1 3 1 abnormal renal tubule epithelial cell primary cilium morphology 0.0575004342375482 0.246183012333737 1.3438960756604 0.5 3.1 3 1 abnormal vitelline vein topology 0.0575004342375482 0.246183012333737 1.3438960756604 0.5 3.1 3 1 abnormal otic capsule morphology 0.105275586474896 0.340537088889863 1.3438960756604 0.5 3.1 3 1 retarded hair growth 0.105275586474896 0.340537088889863 1.3438960756604 0.5 3.1 3 1 abnormal prostate gland epithelium morphology 0.105275586474896 0.340537088889863 1.3438960756604 0.5 3.1 3 1 fused cornea and lens 0.105275586474896 0.340537088889863 1.3438960756604 0.5 3.1 3 1 absent trophoblast giant cells 0.105275586474896 0.340537088889863 1.3438960756604 0.5 3.1 3 1 alcohol preference 0.105275586474896 0.340537088889863 1.3438960756604 0.5 3.1 3 1 decreased incidence of induced tumors 0.105275586474896 0.340537088889863 1.3438960756604 0.5 3.1 3 1 abnormal respiratory mechanics 0.105275586474896 0.340537088889863 1.3438960756604 0.5 3.1 3 1 abnormal airway responsiveness 0.105275586474896 0.340537088889863 1.3438960756604 0.5 3.1 3 1 abnormal primordial germ cell migration 0.105275586474896 0.340537088889863 1.3438960756604 0.5 3.1 3 1 delayed dark adaptation 0.105275586474896 0.340537088889863 1.3438960756604 0.5 3.1 3 1 abnormal tibialis anterior morphology 0.105275586474896 0.340537088889863 1.3438960756604 0.5 3.1 3 1 abnormal scala media morphology 0.105275586474896 0.340537088889863 1.3438960756604 0.5 3.1 3 1 intestinal edema 0.105275586474896 0.340537088889863 1.3438960756604 0.5 3.1 3 1 lymphedema 0.105275586474896 0.340537088889863 1.3438960756604 0.5 3.1 3 1 cochlear ganglion hypoplasia 0.105275586474896 0.340537088889863 1.3438960756604 0.5 3.1 3 1 abnormal submandibular gland morphology 0.105275586474896 0.340537088889863 1.3438960756604 0.5 3.1 3 1 increased left ventricle diastolic pressure 0.105275586474896 0.340537088889863 1.3438960756604 0.5 3.1 3 1 abnormal pillar cell morphology 0.105275586474896 0.340537088889863 1.3438960756604 0.5 3.1 3 1 abnormal gas homeostasis 0.105275586474896 0.340537088889863 1.3438960756604 0.5 3.1 3 1 abnormal cochlear inner hair cell physiology 0.105275586474896 0.340537088889863 1.3438960756604 0.5 3.1 3 1 decreased thyroxine level 0.105275586474896 0.340537088889863 1.3438960756604 0.5 3.1 3 1 crystalluria 0.105275586474896 0.340537088889863 1.3438960756604 0.5 3.1 3 1 decreased transitional stage T2 B cell number 0.105275586474896 0.340537088889863 1.3438960756604 0.5 3.1 3 1 abnormal hippocampus neuron morphology 0.105275586474896 0.340537088889863 1.3438960756604 0.5 3.1 3 1 abnormal cerebellar granule cell migration 0.105275586474896 0.340537088889863 1.3438960756604 0.5 3.1 3 1 increased circulating fructosamine level 0.105275586474896 0.340537088889863 1.3438960756604 0.5 3.1 3 1 acanthocytosis 0.105275586474896 0.340537088889863 1.3438960756604 0.5 3.1 3 1 common ventricle 0.105275586474896 0.340537088889863 1.3438960756604 0.5 3.1 3 1 aorta stenosis 0.105275586474896 0.340537088889863 1.3438960756604 0.5 3.1 3 1 abnormal inferior vena cava valve morphology 0.105275586474896 0.340537088889863 1.3438960756604 0.5 3.1 3 1 thick aortic valve 0.105275586474896 0.340537088889863 1.3438960756604 0.5 3.1 3 1 fusion of atlas and odontoid process 0.105275586474896 0.340537088889863 1.3438960756604 0.5 3.1 3 1 abnormal circadian temperature homeostasis 0.105275586474896 0.340537088889863 1.3438960756604 0.5 3.1 3 1 decreased macrophage apoptosis 0.105275586474896 0.340537088889863 1.3438960756604 0.5 3.1 3 1 lethality during fetal growth through weaning, complete penetrance 0.105275586474896 0.340537088889863 1.3438960756604 0.5 3.1 3 1 abnormal heart morphology 1.79415586331524e-13 2.879330780643e-11 1.33807834373113 0.497835497835498 3.1 3 1 anophthalmia 6.01536584742051e-06 0.000172985231739405 1.3287961197541 0.49438202247191 3.1 3 1 abnormal somite development 2.07581839989264e-05 0.000537874819763847 1.32688473293052 0.493670886075949 3.1 3 1 abnormal placenta labyrinth morphology 2.07581839989264e-05 0.000537874819763847 1.32688473293052 0.493670886075949 3.1 3 1 hemorrhage 2.9690473958361e-13 4.61594087321394e-11 1.32673995554558 0.493617021276596 3.1 3 1 prenatal lethality, incomplete penetrance 1.11655702810894e-16 3.08603956380109e-14 1.3262132325596 0.493421052631579 3.1 3 1 corneal opacity 5.61767364454409e-05 0.00125327024132766 1.3249679619187 0.492957746478873 3.1 3 1 increased osteoclast cell number 0.000196482133881876 0.00332482522470182 1.32186499245285 0.491803278688525 3.1 3 1 abnormal male meiosis 0.000196482133881876 0.00332482522470182 1.32186499245285 0.491803278688525 3.1 3 1 decreased embryo size 4.98041290807804e-25 3.53965060252689e-22 1.32140409113052 0.49163179916318 3.1 3 1 lethality throughout fetal growth and development, incomplete penetrance 2.66796595231879e-10 2.45798715051593e-08 1.3213726777443 0.491620111731844 3.1 3 1 decreased birth body size 4.54153356724734e-07 1.98194118395224e-05 1.320318951526 0.491228070175439 3.1 3 1 increased macrophage cell number 0.000325177694913744 0.00520179753117645 1.320318951526 0.491228070175439 3.1 3 1 abnormal embryo turning 0.00041864834322814 0.00633062464303951 1.31946160155748 0.490909090909091 3.1 3 1 abnormal mesoderm development 0.000539286774953345 0.00775419568032627 1.31853954593096 0.490566037735849 3.1 3 1 atrioventricular septal defect 0.000539286774953345 0.00775419568032627 1.31853954593096 0.490566037735849 3.1 3 1 abnormal trophoblast layer morphology 0.000695105329234363 0.00948059821778393 1.31754517221608 0.490196078431373 3.1 3 1 absent kidney 0.000896525717456399 0.011799511757528 1.31646962513672 0.489795918367347 3.1 3 1 abnormal homeostasis 0.0019321239421945 0.021600711488579 1.31264267855202 0.488372093023256 3.1 3 1 decreased oxygen consumption 0.0019321239421945 0.021600711488579 1.31264267855202 0.488372093023256 3.1 3 1 sparse hair 2.33779220983202e-05 0.000596436730457143 1.31111812259551 0.48780487804878 3.1 3 1 cataract 3.13030665866851e-07 1.42874088319962e-05 1.31057633824733 0.487603305785124 3.1 3 1 increased vascular permeability 0.0032379593847613 0.0318356678640069 1.30943720192552 0.487179487179487 3.1 3 1 abnormal branching of the mammary ductal tree 0.00419838623396333 0.0390410682504067 1.30757456010201 0.486486486486487 3.1 3 1 increased circulating phosphate level 0.00419838623396333 0.0390410682504067 1.30757456010201 0.486486486486487 3.1 3 1 abnormal chromosome morphology 0.00419838623396333 0.0390410682504067 1.30757456010201 0.486486486486487 3.1 3 1 abnormal hair follicle development 0.00419838623396333 0.0390410682504067 1.30757456010201 0.486486486486487 3.1 3 1 abnormal renal glomerulus morphology 1.36058753291081e-06 4.90501664944294e-05 1.30690811027525 0.486238532110092 3.1 3 1 abnormal digit morphology 8.09585922755078e-05 0.00172862230287833 1.30656562911428 0.486111111111111 3.1 3 1 abnormal erythropoiesis 2.22237650990889e-06 7.27389680052418e-05 1.30549904492724 0.485714285714286 3.1 3 1 ovary cysts 0.00545030776603535 0.0463509079248306 1.30549904492724 0.485714285714286 3.1 3 1 increased circulating serum albumin level 0.00545030776603535 0.0463509079248306 1.30549904492724 0.485714285714286 3.1 3 1 pericardial edema 0.000133332992784701 0.00246117849892312 1.30436972049392 0.485294117647059 3.1 3 1 abnormal epidermis stratum basale morphology 0.00708511451339092 0.0548187320437323 1.30317195215554 0.484848484848485 3.1 3 1 decreased caudal vertebrae number 0.000219896121449833 0.00365880670305324 1.30189932329601 0.484375 3.1 3 1 increased sacral vertebrae number 0.000219896121449833 0.00365880670305324 1.30189932329601 0.484375 3.1 3 1 abnormal kidney development 0.000363230506961862 0.00564022545497253 1.29909953980505 0.483333333333333 3.1 3 1 abnormal eating behavior 0.000363230506961862 0.00564022545497253 1.29909953980505 0.483333333333333 3.1 3 1 absent mesoderm 0.000363230506961862 0.00564022545497253 1.29909953980505 0.483333333333333 3.1 3 1 glomerulosclerosis 0.000467143629067178 0.00693743150629615 1.29755483167211 0.482758620689655 3.1 3 1 abnormal embryonic erythropoiesis 0.0120296656378987 0.0844893732731362 1.29755483167211 0.482758620689655 3.1 3 1 abnormal eye morphology 9.01273964688288e-08 4.67066455658774e-06 1.29555449020499 0.482014388489209 3.1 3 1 increased sensitivity to xenobiotic induced morbidity/mortality 1.93599226707686e-06 6.46413525416603e-05 1.29502712745457 0.481818181818182 3.1 3 1 abnormal trigeminal nerve morphology 0.0157187282967792 0.102895622732206 1.29412214693224 0.481481481481481 3.1 3 1 increased brain weight 0.0157187282967792 0.102895622732206 1.29412214693224 0.481481481481481 3.1 3 1 abnormal fetal cardiomyocyte proliferation 0.0157187282967792 0.102895622732206 1.29412214693224 0.481481481481481 3.1 3 1 decreased B cell proliferation 5.47356120498465e-05 0.0012396863418345 1.29286204747076 0.481012658227848 3.1 3 1 abnormal retina morphology 6.7217918705987e-11 7.11508820345288e-09 1.29270003468286 0.480952380952381 3.1 3 1 decreased cardiac muscle contractility 4.03630246770538e-06 0.000119527409385918 1.29220776505807 0.480769230769231 3.1 3 1 distended pericardium 0.000996701576434718 0.0127143342122121 1.29220776505807 0.480769230769231 3.1 3 1 abnormal snout morphology 0.000996701576434718 0.0127143342122121 1.29220776505807 0.480769230769231 3.1 3 1 liver hypoplasia 0.000996701576434718 0.0127143342122121 1.29220776505807 0.480769230769231 3.1 3 1 increased susceptibility to injury 0.000996701576434718 0.0127143342122121 1.29220776505807 0.480769230769231 3.1 3 1 abnormal limb morphology 8.9871296707859e-05 0.00183033970614628 1.29014023263398 0.48 3.1 3 1 abnormal hindlimb morphology 0.00128458266299142 0.0156637224225057 1.29014023263398 0.48 3.1 3 1 increased body length 0.00128458266299142 0.0156637224225057 1.29014023263398 0.48 3.1 3 1 ruffled hair 0.0205846180009879 0.118224312026175 1.29014023263398 0.48 3.1 3 1 abnormal thyroid gland morphology 0.0205846180009879 0.118224312026175 1.29014023263398 0.48 3.1 3 1 decreased placenta weight 0.0205846180009879 0.118224312026175 1.29014023263398 0.48 3.1 3 1 abnormal energy expenditure 0.0205846180009879 0.118224312026175 1.29014023263398 0.48 3.1 3 1 decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 0.0205846180009879 0.118224312026175 1.29014023263398 0.48 3.1 3 1 abnormal bone mineralization 8.06745528411361e-07 3.13559297175509e-05 1.28836317997195 0.479338842975207 3.1 3 1 fragile skeleton 0.0270258361981767 0.143493634029807 1.28546581150125 0.478260869565217 3.1 3 1 abnormal sacral vertebrae morphology 0.0270258361981767 0.143493634029807 1.28546581150125 0.478260869565217 3.1 3 1 abnormal corneal stroma morphology 0.0270258361981767 0.143493634029807 1.28546581150125 0.478260869565217 3.1 3 1 abnormal chondrocyte physiology 0.0270258361981767 0.143493634029807 1.28546581150125 0.478260869565217 3.1 3 1 abnormal vertebral artery topology 0.0270258361981767 0.143493634029807 1.28546581150125 0.478260869565217 3.1 3 1 increased spleen weight 2.14033668310495e-06 7.05177152215043e-05 1.28443164753383 0.47787610619469 3.1 3 1 muscular atrophy 0.00276131383116648 0.0278566085454293 1.28280989040311 0.477272727272727 3.1 3 1 embryonic lethality, incomplete penetrance 0.00276131383116648 0.0278566085454293 1.28280989040311 0.477272727272727 3.1 3 1 double outlet right ventricle 4.45279703411799e-06 0.000131080859436314 1.28109719362019 0.476635514018692 3.1 3 1 abnormal scapula morphology 0.0355887993160473 0.178662236727886 1.27990102443847 0.476190476190476 3.1 3 1 increased keratinocyte proliferation 0.0355887993160473 0.178662236727886 1.27990102443847 0.476190476190476 3.1 3 1 abnormal tumor vascularization 0.0355887993160473 0.178662236727886 1.27990102443847 0.476190476190476 3.1 3 1 skin lesions 0.000400488804772842 0.0060744872065393 1.27990102443847 0.476190476190476 3.1 3 1 abnormal blood vessel morphology 1.09910169451084e-07 5.57962339815453e-06 1.27901833407679 0.475862068965517 3.1 3 1 decreased cell proliferation 2.18056262076006e-09 1.66896908281251e-07 1.2785173476553 0.475675675675676 3.1 3 1 abnormal developmental patterning 6.02848853238265e-05 0.00133891653788409 1.27834016953062 0.475609756097561 3.1 3 1 embryonic lethality during organogenesis, complete penetrance 2.82776046419069e-25 2.81362166186974e-22 1.27670127187738 0.475 3.1 3 1 abnormal skin pigmentation 0.00461762320641924 0.0417685008217014 1.27670127187738 0.475 3.1 3 1 increased susceptibility to weight loss 0.00461762320641924 0.0417685008217014 1.27670127187738 0.475 3.1 3 1 deafness 1.18402341836059e-05 0.000323654753095821 1.27602253648563 0.474747474747475 3.1 3 1 abnormal colon morphology 0.000660828442980171 0.00910698477514225 1.275562376898 0.474576271186441 3.1 3 1 increased B cell proliferation 0.000660828442980171 0.00910698477514225 1.275562376898 0.474576271186441 3.1 3 1 decreased brain weight 0.000849377465081024 0.0112985371357703 1.27316470325722 0.473684210526316 3.1 3 1 decreased hair follicle number 0.00597982058789952 0.0487698482373772 1.27316470325722 0.473684210526316 3.1 3 1 irregular coat pigmentation 0.0470309534043266 0.217654877382814 1.27316470325722 0.473684210526316 3.1 3 1 flaky skin 0.0470309534043266 0.217654877382814 1.27316470325722 0.473684210526316 3.1 3 1 decreased grooming behavior 0.0470309534043266 0.217654877382814 1.27316470325722 0.473684210526316 3.1 3 1 altered susceptibility to infection 0.0470309534043266 0.217654877382814 1.27316470325722 0.473684210526316 3.1 3 1 decreased tumor incidence 0.0470309534043266 0.217654877382814 1.27316470325722 0.473684210526316 3.1 3 1 increased susceptibility to ischemic brain injury 0.0470309534043266 0.217654877382814 1.27316470325722 0.473684210526316 3.1 3 1 absent amnion 0.0470309534043266 0.217654877382814 1.27316470325722 0.473684210526316 3.1 3 1 eyelids fail to open 0.0470309534043266 0.217654877382814 1.27316470325722 0.473684210526316 3.1 3 1 cleft palate 5.99256926795309e-07 2.50529681580392e-05 1.27208483497625 0.473282442748092 3.1 3 1 renal hypoplasia 0.00775219397483328 0.0584350985224175 1.26923518256815 0.472222222222222 3.1 3 1 head tilt 0.00775219397483328 0.0584350985224175 1.26923518256815 0.472222222222222 3.1 3 1 abnormal retinal blood vessel morphology 0.00775219397483328 0.0584350985224175 1.26923518256815 0.472222222222222 3.1 3 1 decreased mean corpuscular hemoglobin 0.000340607308298375 0.00543115820123211 1.26484336532743 0.470588235294118 3.1 3 1 hyperlipidemia 0.0624167636931412 0.256311704662904 1.26484336532743 0.470588235294118 3.1 3 1 abnormal testis development 0.0624167636931412 0.256311704662904 1.26484336532743 0.470588235294118 3.1 3 1 abnormal embryonic-extraembryonic boundary morphology 0.0624167636931412 0.256311704662904 1.26484336532743 0.470588235294118 3.1 3 1 enhanced behavioral response to cocaine 0.0624167636931412 0.256311704662904 1.26484336532743 0.470588235294118 3.1 3 1 increased circulating magnesium level 0.0624167636931412 0.256311704662904 1.26484336532743 0.470588235294118 3.1 3 1 decreased bone mineral density 3.01371423447901e-12 4.28377951900945e-10 1.26306022148534 0.469924812030075 3.1 3 1 short tail 8.41434640848505e-05 0.00175888123454677 1.2629384807411 0.469879518072289 3.1 3 1 decreased heart weight 0.00010757784911645 0.00209153560970113 1.26093952778013 0.469135802469136 3.1 3 1 increased bone mineral density 5.31265181838665e-06 0.000154563992961834 1.26064587628321 0.469026548672566 3.1 3 1 abnormal diaphragm morphology 0.0130767760146548 0.0886733589255141 1.25990257093162 0.46875 3.1 3 1 abnormal heart development 8.82281888491753e-08 4.6203709423647e-06 1.25883936201101 0.468354430379747 3.1 3 1 premature death 1.58370508427467e-35 3.93946639713324e-32 1.25492734591285 0.466898954703833 3.1 3 1 kyphosis 2.30695602308486e-07 1.11428215678128e-05 1.2543030039497 0.466666666666667 3.1 3 1 intracranial hemorrhage 0.000921226636996198 0.0119976505734453 1.2543030039497 0.466666666666667 3.1 3 1 abnormal long bone epiphyseal plate morphology 0.000921226636996198 0.0119976505734453 1.2543030039497 0.466666666666667 3.1 3 1 increased erythrocyte cell number 0.000921226636996198 0.0119976505734453 1.2543030039497 0.466666666666667 3.1 3 1 albuminuria 0.00386968226392548 0.0368100750727137 1.2543030039497 0.466666666666667 3.1 3 1 abnormal optic cup morphology 0.0170201266950958 0.109767690140294 1.2543030039497 0.466666666666667 3.1 3 1 audiogenic seizures 0.0832686953633294 0.291939224406317 1.2543030039497 0.466666666666667 3.1 3 1 abnormal apical ectodermal ridge morphology 0.0832686953633294 0.291939224406317 1.2543030039497 0.466666666666667 3.1 3 1 abnormal dendritic cell morphology 0.0832686953633294 0.291939224406317 1.2543030039497 0.466666666666667 3.1 3 1 lactation failure 0.0832686953633294 0.291939224406317 1.2543030039497 0.466666666666667 3.1 3 1 ostium primum atrial septal defect 0.0832686953633294 0.291939224406317 1.2543030039497 0.466666666666667 3.1 3 1 abnormal microglial cell activation 0.0832686953633294 0.291939224406317 1.2543030039497 0.466666666666667 3.1 3 1 decreased brown adipose tissue mass 0.0832686953633294 0.291939224406317 1.2543030039497 0.466666666666667 3.1 3 1 astrocytosis 0.000287857276855459 0.00463459531506767 1.2518483992453 0.465753424657534 3.1 3 1 reduced female fertility 1.75024253692615e-10 1.7073444355309e-08 1.25121358768382 0.46551724137931 3.1 3 1 ataxia 2.62586368385143e-09 1.9793442162365e-07 1.25075476348591 0.465346534653465 3.1 3 1 abnormal organ of Corti morphology 0.00499278225227836 0.0441191682150707 1.25013588433525 0.465116279069767 3.1 3 1 abnormal vasculogenesis 0.00499278225227836 0.0441191682150707 1.25013588433525 0.465116279069767 3.1 3 1 kidney failure 0.00499278225227836 0.0441191682150707 1.25013588433525 0.465116279069767 3.1 3 1 abnormal skeletal muscle fiber morphology 0.000368311273398903 0.00568938816326147 1.24925550695192 0.464788732394366 3.1 3 1 anemia 1.38565418569334e-09 1.07712962091005e-07 1.24835843994994 0.464454976303318 3.1 3 1 hydronephrosis 0.0001162378974246 0.00221379479419526 1.24790349882751 0.464285714285714 3.1 3 1 increased food intake 0.0001162378974246 0.00221379479419526 1.24790349882751 0.464285714285714 3.1 3 1 improved glucose tolerance 5.37230023237298e-09 3.71211023000772e-07 1.24790349882751 0.464285714285714 3.1 3 1 premature aging 0.0221891543671461 0.123153265474817 1.24790349882751 0.464285714285714 3.1 3 1 hypoxia 0.0221891543671461 0.123153265474817 1.24790349882751 0.464285714285714 3.1 3 1 abnormal brainstem morphology 0.0221891543671461 0.123153265474817 1.24790349882751 0.464285714285714 3.1 3 1 prolonged QRS complex duration 0.0221891543671461 0.123153265474817 1.24790349882751 0.464285714285714 3.1 3 1 embryonic lethality before implantation, complete penetrance 3.00857255395975e-06 9.30716872844319e-05 1.24713555821285 0.464 3.1 3 1 abnormal myocardial fiber morphology 3.70237987368499e-05 0.000877111422456326 1.24691388463336 0.463917525773196 3.1 3 1 postnatal lethality 8.11522449980068e-08 4.3412088050009e-06 1.24674696175724 0.463855421686747 3.1 3 1 decreased birth weight 4.71988075597588e-05 0.00109726199817663 1.24487215429595 0.463157894736842 3.1 3 1 short snout 1.51178653102237e-05 0.00040654799955872 1.24434821820407 0.462962962962963 3.1 3 1 abnormal mandible morphology 0.00194934237065253 0.0216472729776703 1.24434821820407 0.462962962962963 3.1 3 1 polyphagia 0.00194934237065253 0.0216472729776703 1.24434821820407 0.462962962962963 3.1 3 1 neurodegeneration 0.00194934237065253 0.0216472729776703 1.24434821820407 0.462962962962963 3.1 3 1 pallor 4.26813005665807e-08 2.46906360835743e-06 1.2440637957542 0.462857142857143 3.1 3 1 internal hemorrhage 0.00060328031803644 0.00857519880637511 1.24360532374544 0.462686567164179 3.1 3 1 abnormal leukocyte migration 0.00250444331989296 0.0260661203273378 1.24051945445575 0.461538461538462 3.1 3 1 abnormal heart looping 0.00832998733344654 0.0619457204542549 1.24051945445575 0.461538461538462 3.1 3 1 abnormal nasal bone morphology 0.028981916165339 0.150303744035708 1.24051945445575 0.461538461538462 3.1 3 1 abnormal stomach morphology 0.028981916165339 0.150303744035708 1.24051945445575 0.461538461538462 3.1 3 1 thick skin 0.028981916165339 0.150303744035708 1.24051945445575 0.461538461538462 3.1 3 1 pulmonary edema 0.028981916165339 0.150303744035708 1.24051945445575 0.461538461538462 3.1 3 1 short premaxilla 0.111815160335059 0.357047768078896 1.24051945445575 0.461538461538462 3.1 3 1 increased foot pad pigmentation 0.111815160335059 0.357047768078896 1.24051945445575 0.461538461538462 3.1 3 1 tight skin 0.111815160335059 0.357047768078896 1.24051945445575 0.461538461538462 3.1 3 1 increased pituitary adenoma incidence 0.111815160335059 0.357047768078896 1.24051945445575 0.461538461538462 3.1 3 1 abnormal bile duct development 0.111815160335059 0.357047768078896 1.24051945445575 0.461538461538462 3.1 3 1 abnormal coping response 0.111815160335059 0.357047768078896 1.24051945445575 0.461538461538462 3.1 3 1 abnormal soleus morphology 0.111815160335059 0.357047768078896 1.24051945445575 0.461538461538462 3.1 3 1 abnormal insulin secretion 0.111815160335059 0.357047768078896 1.24051945445575 0.461538461538462 3.1 3 1 small otic vesicle 0.111815160335059 0.357047768078896 1.24051945445575 0.461538461538462 3.1 3 1 abnormal vertebral arch development 0.111815160335059 0.357047768078896 1.24051945445575 0.461538461538462 3.1 3 1 increased circulating thyroxine level 0.111815160335059 0.357047768078896 1.24051945445575 0.461538461538462 3.1 3 1 reduced fertility 1.33003783080834e-06 4.82988190384782e-05 1.2375445876585 0.460431654676259 3.1 3 1 kidney inflammation 0.00321889974171726 0.0317109430000859 1.23638438960757 0.46 3.1 3 1 decreased respiratory quotient 0.00321889974171726 0.0317109430000859 1.23638438960757 0.46 3.1 3 1 abnormal retinal pigmentation 0.000124693083367408 0.00234093618774663 1.23576650635439 0.459770114942529 3.1 3 1 abnormal angiogenesis 0.000394880136435314 0.00604130068095282 1.23493152898523 0.459459459459459 3.1 3 1 abnormal intestine morphology 0.000394880136435314 0.00604130068095282 1.23493152898523 0.459459459459459 3.1 3 1 increased insulin secretion 0.0107729305545727 0.0762345972433626 1.23493152898523 0.459459459459459 3.1 3 1 increased trabecular bone volume 0.0107729305545727 0.0762345972433626 1.23493152898523 0.459459459459459 3.1 3 1 embryonic growth arrest 9.02838960907039e-10 7.36331775493856e-08 1.23239378117329 0.458515283842795 3.1 3 1 abnormal forebrain development 0.000504430785243376 0.00740278217281946 1.23190473602203 0.458333333333333 3.1 3 1 overriding aortic valve 0.00413891876313584 0.0387780053608301 1.23190473602203 0.458333333333333 3.1 3 1 vertebral transformation 0.00413891876313584 0.0387780053608301 1.23190473602203 0.458333333333333 3.1 3 1 curly tail 0.00413891876313584 0.0387780053608301 1.23190473602203 0.458333333333333 3.1 3 1 abnormal digestive system morphology 0.0379343791965766 0.185182766082997 1.23190473602203 0.458333333333333 3.1 3 1 abnormal sensory capabilities/reflexes/nociception 0.0379343791965766 0.185182766082997 1.23190473602203 0.458333333333333 3.1 3 1 abnormal impulse conducting system conduction 0.0379343791965766 0.185182766082997 1.23190473602203 0.458333333333333 3.1 3 1 abnormal cellular extravasation 0.0379343791965766 0.185182766082997 1.23190473602203 0.458333333333333 3.1 3 1 embryonic lethality between implantation and somite formation, complete penetrance 3.16020049109843e-10 2.8585449896754e-08 1.22870498346094 0.457142857142857 3.1 3 1 increased circulating HDL cholesterol level 3.33404928321645e-05 0.000797446883846243 1.22870498346094 0.457142857142857 3.1 3 1 embryonic lethality between somite formation and embryo turning, complete penetrance 0.000644430450951529 0.00895542316615602 1.22870498346093 0.457142857142857 3.1 3 1 holoprosencephaly 0.0139452028689377 0.093880086972889 1.22870498346093 0.457142857142857 3.1 3 1 decreased circulating thyroxine level 0.0139452028689377 0.093880086972889 1.22870498346093 0.457142857142857 3.1 3 1 abnormal forelimb morphology 0.00532427229266431 0.0461305314630035 1.2270355473421 0.456521739130435 3.1 3 1 abnormal myelin sheath morphology 0.00532427229266431 0.0461305314630035 1.2270355473421 0.456521739130435 3.1 3 1 abnormal cell morphology 1.72921565721251e-05 0.000455177137282129 1.22601045498843 0.456140350877193 3.1 3 1 abnormal craniofacial bone morphology 0.00207850382735595 0.0227113714335904 1.22601045498843 0.456140350877193 3.1 3 1 impaired natural killer cell mediated cytotoxicity 0.00207850382735595 0.0227113714335904 1.22601045498843 0.456140350877193 3.1 3 1 abnormal embryonic tissue morphology 1.19486391693693e-06 4.43615521400092e-05 1.22504812339111 0.45578231292517 3.1 3 1 thin ventricular wall 0.000132895986516408 0.00246117849892312 1.22443864671281 0.455555555555556 3.1 3 1 increased blood urea nitrogen level 1.51488549815261e-06 5.38325382379232e-05 1.22340884129085 0.455172413793103 3.1 3 1 polyuria 0.000420171895136304 0.00633440963122155 1.22172370514582 0.454545454545455 3.1 3 1 abnormal vascular development 0.00105205551091016 0.0133519800172909 1.22172370514582 0.454545454545455 3.1 3 1 abnormal head morphology 0.00266362513493983 0.0272294600414912 1.22172370514582 0.454545454545455 3.1 3 1 renal interstitial fibrosis 0.0068523392698716 0.0531002926286779 1.22172370514582 0.454545454545455 3.1 3 1 single kidney 0.0180698272657081 0.115468534767828 1.22172370514582 0.454545454545455 3.1 3 1 increased body size 0.0497729615912687 0.219890440658857 1.22172370514582 0.454545454545455 3.1 3 1 intracerebral hemorrhage 0.0497729615912687 0.219890440658857 1.22172370514582 0.454545454545455 3.1 3 1 testis hypoplasia 0.0497729615912687 0.219890440658857 1.22172370514582 0.454545454545455 3.1 3 1 increased myocardial infarction size 0.0497729615912687 0.219890440658857 1.22172370514582 0.454545454545455 3.1 3 1 abnormal blood-brain barrier function 0.0497729615912687 0.219890440658857 1.22172370514582 0.454545454545455 3.1 3 1 decreased susceptibility to viral infection induced morbidity/mortality 0.0497729615912687 0.219890440658857 1.22172370514582 0.454545454545455 3.1 3 1 failure of palatal shelf elevation 0.0497729615912687 0.219890440658857 1.22172370514582 0.454545454545455 3.1 3 1 pulmonary vascular congestion 0.0497729615912687 0.219890440658857 1.22172370514582 0.454545454545455 3.1 3 1 embryonic lethality before implantation, incomplete penetrance 0.0497729615912687 0.219890440658857 1.22172370514582 0.454545454545455 3.1 3 1 abnormal ear position 0.151421270764471 0.426372047425988 1.22172370514582 0.454545454545455 3.1 3 1 abnormal thrombopoiesis 0.151421270764471 0.426372047425988 1.22172370514582 0.454545454545455 3.1 3 1 decreased atrioventricular cushion size 0.151421270764471 0.426372047425988 1.22172370514582 0.454545454545455 3.1 3 1 enlarged cranium 0.151421270764471 0.426372047425988 1.22172370514582 0.454545454545455 3.1 3 1 abnormal stomach epithelium morphology 0.151421270764471 0.426372047425988 1.22172370514582 0.454545454545455 3.1 3 1 abnormal eye distance/ position 0.151421270764471 0.426372047425988 1.22172370514582 0.454545454545455 3.1 3 1 abnormal hemoglobin 0.151421270764471 0.426372047425988 1.22172370514582 0.454545454545455 3.1 3 1 secondary sex reversal 0.151421270764471 0.426372047425988 1.22172370514582 0.454545454545455 3.1 3 1 allodynia 0.151421270764471 0.426372047425988 1.22172370514582 0.454545454545455 3.1 3 1 fused joints 0.151421270764471 0.426372047425988 1.22172370514582 0.454545454545455 3.1 3 1 impaired luteinization 0.151421270764471 0.426372047425988 1.22172370514582 0.454545454545455 3.1 3 1 abnormal lymph circulation 0.151421270764471 0.426372047425988 1.22172370514582 0.454545454545455 3.1 3 1 pathological neovascularization 0.151421270764471 0.426372047425988 1.22172370514582 0.454545454545455 3.1 3 1 abnormal hair medulla 0.151421270764471 0.426372047425988 1.22172370514582 0.454545454545455 3.1 3 1 abnormal coronal suture morphology 0.151421270764471 0.426372047425988 1.22172370514582 0.454545454545455 3.1 3 1 increased circulating triiodothyronine level 0.151421270764471 0.426372047425988 1.22172370514582 0.454545454545455 3.1 3 1 abnormal aorta smooth muscle morphology 0.151421270764471 0.426372047425988 1.22172370514582 0.454545454545455 3.1 3 1 increased number of Howell-Jolly bodies 0.151421270764471 0.426372047425988 1.22172370514582 0.454545454545455 3.1 3 1 common atrioventricular valve 0.151421270764471 0.426372047425988 1.22172370514582 0.454545454545455 3.1 3 1 abnormal pulmonary alveolar sac morphology 0.151421270764471 0.426372047425988 1.22172370514582 0.454545454545455 3.1 3 1 thin hypoglossal nerve 0.151421270764471 0.426372047425988 1.22172370514582 0.454545454545455 3.1 3 1 preweaning lethality, complete penetrance 3.86851472417349e-27 5.17722763495051e-24 1.22040292276187 0.454054054054054 3.1 3 1 abnormal brain morphology 5.23131304059085e-07 2.24360192904651e-05 1.21868836674794 0.453416149068323 3.1 3 1 abnormal neurocranium morphology 0.000535743765333199 0.00774803846666472 1.21846577526543 0.453333333333333 3.1 3 1 abnormal pancreatic islet morphology 0.00341423835771949 0.0333709937714233 1.21711342701319 0.452830188679245 3.1 3 1 alopecia 0.000110772530745164 0.00213602069944647 1.21657960533468 0.452631578947368 3.1 3 1 decreased leukocyte cell number 3.90948239543393e-06 0.000117876817680508 1.21637309037875 0.452554744525547 3.1 3 1 skin edema 0.00882337360738258 0.0654192007402807 1.21590597321655 0.452380952380952 3.1 3 1 abnormal reproductive system morphology 0.00882337360738258 0.0654192007402807 1.21590597321655 0.452380952380952 3.1 3 1 abnormal fertility/fecundity 0.00068310392966341 0.00938796146429687 1.21502932867926 0.452054794520548 3.1 3 1 prenatal lethality 0.00171809875158194 0.019514934450046 1.21384161672552 0.451612903225806 3.1 3 1 pericardial effusion 0.00171809875158194 0.019514934450046 1.21384161672552 0.451612903225806 3.1 3 1 lethargy 0.000140806459010595 0.00253808744049896 1.21384161672552 0.451612903225806 3.1 3 1 perinatal lethality, incomplete penetrance 4.4510123363829e-09 3.21833965057623e-07 1.21307433378195 0.451327433628319 3.1 3 1 abnormal response to novel object 0.00437739103491151 0.0403287414790458 1.21214155843879 0.450980392156863 3.1 3 1 cochlear inner hair cell degeneration 0.00437739103491151 0.0403287414790458 1.21214155843879 0.450980392156863 3.1 3 1 small spleen 0.000178966555993984 0.00304917334270572 1.21098327696871 0.450549450549451 3.1 3 1 decreased heart rate 9.2109361006827e-05 0.0018477583508426 1.20950646809436 0.45 3.1 3 1 abnormal hair texture 0.065489974731364 0.261363530258807 1.20950646809436 0.45 3.1 3 1 increased skin tumor incidence 0.065489974731364 0.261363530258807 1.20950646809436 0.45 3.1 3 1 preweaning lethality, incomplete penetrance 5.18895362416106e-15 1.03260177120805e-12 1.20917788714676 0.449877750611247 3.1 3 1 abnormal muscle physiology 0.000227444860587103 0.0037592630611988 1.20799647250373 0.449438202247191 3.1 3 1 decreased spleen weight 0.00111053559365245 0.0138469037053156 1.20755879262239 0.449275362318841 3.1 3 1 increased sarcoma incidence 0.0056135745893549 0.0474151673718857 1.20676382304199 0.448979591836735 3.1 3 1 abnormal craniofacial development 0.0056135745893549 0.0474151673718857 1.20676382304199 0.448979591836735 3.1 3 1 decreased bone strength 0.0304437389596596 0.155820577494143 1.20487234369553 0.448275862068966 3.1 3 1 decreased circulating glucose level 1.55396967707612e-10 1.54619982869074e-08 1.20420795310072 0.448028673835125 3.1 3 1 increased bone marrow cell number 0.0146530671942606 0.0978510191831494 1.20243333085404 0.447368421052632 3.1 3 1 pulmonary hypoplasia 0.00720058093709103 0.0554533903436964 1.20092840803695 0.446808510638298 3.1 3 1 abnormal craniofacial morphology 9.68933951587584e-05 0.00193592225266997 1.20037319379375 0.446601941747573 3.1 3 1 increased body weight 1.25617885763516e-08 8.01216643171146e-07 1.19990721041107 0.446428571428571 3.1 3 1 weight loss 5.12016957154632e-07 2.2150298798646e-05 1.19798735887441 0.445714285714286 3.1 3 1 postnatal growth retardation 1.33940779474381e-20 6.66355377885047e-18 1.19457428947591 0.444444444444444 3.1 3 1 decreased circulating serum albumin level 0.000155623070089093 0.00273577658548847 1.19457428947591 0.444444444444444 3.1 3 1 increased mean corpuscular hemoglobin 0.000155623070089093 0.00273577658548847 1.19457428947591 0.444444444444444 3.1 3 1 increased cell proliferation 0.00458615514737304 0.0416352588652935 1.19457428947591 0.444444444444444 3.1 3 1 diluted coat color 0.00458615514737304 0.0416352588652935 1.19457428947591 0.444444444444444 3.1 3 1 abnormal osteoblast physiology 0.00458615514737304 0.0416352588652935 1.19457428947591 0.444444444444444 3.1 3 1 abnormal lysosome morphology 0.0188996099842212 0.117224982318735 1.19457428947591 0.444444444444444 3.1 3 1 narrow eye opening 0.0188996099842212 0.117224982318735 1.19457428947591 0.444444444444444 3.1 3 1 abnormal trigeminal ganglion morphology 0.0395924664601869 0.189944571494146 1.19457428947591 0.444444444444444 3.1 3 1 abnormal skin appearance 0.0395924664601869 0.189944571494146 1.19457428947591 0.444444444444444 3.1 3 1 thick interventricular septum 0.0395924664601869 0.189944571494146 1.19457428947591 0.444444444444444 3.1 3 1 decreased bone ossification 0.0395924664601869 0.189944571494146 1.19457428947591 0.444444444444444 3.1 3 1 abnormal mitral valve morphology 0.0864538688366159 0.298686109348725 1.19457428947591 0.444444444444444 3.1 3 1 abnormal mammary gland morphology 0.0864538688366159 0.298686109348725 1.19457428947591 0.444444444444444 3.1 3 1 abnormal phrenic nerve morphology 0.0864538688366159 0.298686109348725 1.19457428947591 0.444444444444444 3.1 3 1 thick dermal layer 0.0864538688366159 0.298686109348725 1.19457428947591 0.444444444444444 3.1 3 1 abnormal thymus medulla morphology 0.0864538688366159 0.298686109348725 1.19457428947591 0.444444444444444 3.1 3 1 abnormal bile duct morphology 0.0864538688366159 0.298686109348725 1.19457428947591 0.444444444444444 3.1 3 1 acidosis 0.0864538688366159 0.298686109348725 1.19457428947591 0.444444444444444 3.1 3 1 long tibia 0.0864538688366159 0.298686109348725 1.19457428947591 0.444444444444444 3.1 3 1 darkened coat color 0.0864538688366159 0.298686109348725 1.19457428947591 0.444444444444444 3.1 3 1 jerky movement 0.0864538688366159 0.298686109348725 1.19457428947591 0.444444444444444 3.1 3 1 decreased lactate dehydrogenase level 0.0864538688366159 0.298686109348725 1.19457428947591 0.444444444444444 3.1 3 1 small thoracic cage 0.0864538688366159 0.298686109348725 1.19457428947591 0.444444444444444 3.1 3 1 atrioventricular block 0.0864538688366159 0.298686109348725 1.19457428947591 0.444444444444444 3.1 3 1 primary atelectasis 0.0864538688366159 0.298686109348725 1.19457428947591 0.444444444444444 3.1 3 1 postnatal lethality, incomplete penetrance 4.57865274223613e-19 1.51858649284165e-16 1.19247116572683 0.443661971830986 3.1 3 1 increased tumor incidence 2.70913684367658e-05 0.000677284210919145 1.19216587356971 0.443548387096774 3.1 3 1 decreased total body fat amount 9.38898510574454e-12 1.16775502252698e-09 1.19099771974694 0.44311377245509 3.1 3 1 kinked neural tube 0.00586283232613309 0.0482839004893411 1.18883114385343 0.442307692307692 3.1 3 1 increased percent body fat/body weight 0.00586283232613309 0.0482839004893411 1.18883114385343 0.442307692307692 3.1 3 1 thymus hypoplasia 1.16193495457252e-05 0.000319371624254048 1.18808203790267 0.442028985507246 3.1 3 1 abnormal blood circulation 0.0118559250968401 0.0836641522791197 1.18762909011849 0.441860465116279 3.1 3 1 decreased body length 9.01500302105285e-10 7.36331775493856e-08 1.18694470915991 0.441605839416058 3.1 3 1 short maxilla 0.024391936488266 0.133046872684467 1.18579065499447 0.441176470588235 3.1 3 1 lung hemorrhage 0.024391936488266 0.133046872684467 1.18579065499447 0.441176470588235 3.1 3 1 increased susceptibility to weight gain 0.024391936488266 0.133046872684467 1.18579065499447 0.441176470588235 3.1 3 1 increased susceptibility to viral infection induced morbidity/mortality 0.024391936488266 0.133046872684467 1.18579065499447 0.441176470588235 3.1 3 1 abnormal bone structure 3.05463074338924e-07 1.40710999521865e-05 1.18374265731745 0.440414507772021 3.1 3 1 delayed bone ossification 0.00121314585218277 0.0150885015365232 1.18262854658115 0.44 3.1 3 1 abnormal feces composition 0.0515663344216818 0.226427637906326 1.18262854658115 0.44 3.1 3 1 abnormal dendritic cell physiology 0.000133736761257634 0.00246117849892312 1.18061898235586 0.439252336448598 3.1 3 1 thick ventricular wall 0.0152185007840548 0.100148202910943 1.18000631033596 0.439024390243902 3.1 3 1 hemopericardium 0.0152185007840548 0.100148202910943 1.18000631033596 0.439024390243902 3.1 3 1 decreased body weight 3.72126643491697e-38 1.85133005137119e-34 1.17889429577318 0.438610662358643 3.1 3 1 incomplete embryo turning 0.00476664833268502 0.0430382494648057 1.17885620671965 0.43859649122807 3.1 3 1 spleen hypoplasia 0.000168948580191838 0.00293887827431606 1.1775089424834 0.438095238095238 3.1 3 1 scoliosis 0.0315007817850083 0.160588777503032 1.17590906620285 0.4375 3.1 3 1 abnormal lymphatic vessel morphology 0.0315007817850083 0.160588777503032 1.17590906620285 0.4375 3.1 3 1 abnormal serotonin level 0.0315007817850083 0.160588777503032 1.17590906620285 0.4375 3.1 3 1 abnormal hair follicle orientation 0.114573762368447 0.360218410879871 1.17590906620285 0.4375 3.1 3 1 mixed cellular infiltration to dermis 0.114573762368447 0.360218410879871 1.17590906620285 0.4375 3.1 3 1 increased intestinal adenocarcinoma incidence 0.114573762368447 0.360218410879871 1.17590906620285 0.4375 3.1 3 1 impaired muscle relaxation 0.114573762368447 0.360218410879871 1.17590906620285 0.4375 3.1 3 1 abnormal amnion morphology 0.114573762368447 0.360218410879871 1.17590906620285 0.4375 3.1 3 1 decreased circulating prolactin level 0.114573762368447 0.360218410879871 1.17590906620285 0.4375 3.1 3 1 abnormal intestinal lipid absorption 0.114573762368447 0.360218410879871 1.17590906620285 0.4375 3.1 3 1 abnormal fertilization 0.114573762368447 0.360218410879871 1.17590906620285 0.4375 3.1 3 1 impaired somite development 0.114573762368447 0.360218410879871 1.17590906620285 0.4375 3.1 3 1 decreased skeletal muscle weight 0.114573762368447 0.360218410879871 1.17590906620285 0.4375 3.1 3 1 embryonic lethality between somite formation and embryo turning, incomplete penetrance 0.114573762368447 0.360218410879871 1.17590906620285 0.4375 3.1 3 1 decreased midbrain size 0.114573762368447 0.360218410879871 1.17590906620285 0.4375 3.1 3 1 short limbs 0.000641337954869431 0.00893741267640174 1.17397818103667 0.436781609195402 3.1 3 1 atelectasis 0.00195381015293314 0.0216485646121211 1.17354305198514 0.436619718309859 3.1 3 1 increased circulating calcium level 0.00607456547957936 0.0493806589230511 1.17285475693998 0.436363636363636 3.1 3 1 abnormal platelet physiology 0.00607456547957936 0.0493806589230511 1.17285475693998 0.436363636363636 3.1 3 1 decreased neutrophil cell number 9.03430292175306e-05 0.00183033970614628 1.17160170698599 0.435897435897436 3.1 3 1 increased B cell number 9.03430292175306e-05 0.00183033970614628 1.17160170698599 0.435897435897436 3.1 3 1 absent gastric milk in neonates 0.00125731093130124 0.0154205344911937 1.17160170698599 0.435897435897436 3.1 3 1 abnormal iris morphology 0.0195390834503441 0.117224982318735 1.17160170698599 0.435897435897436 3.1 3 1 acanthosis 0.0195390834503441 0.117224982318735 1.17160170698599 0.435897435897436 3.1 3 1 abnormal leukocyte adhesion 0.0195390834503441 0.117224982318735 1.17160170698599 0.435897435897436 3.1 3 1 abnormal circulating hormone level 0.0195390834503441 0.117224982318735 1.17160170698599 0.435897435897436 3.1 3 1 abnormal locomotor behavior 0.000524670415670194 0.00761001550425427 1.16860528318295 0.434782608695652 3.1 3 1 perimembraneous ventricular septal defect 0.00247852214194454 0.0259592582235243 1.16860528318295 0.434782608695652 3.1 3 1 abnormal cell death 0.0122493822453702 0.0847575475253363 1.16860528318295 0.434782608695652 3.1 3 1 abnormal pulmonary artery morphology 0.0672707503551856 0.261363530258807 1.16860528318295 0.434782608695652 3.1 3 1 abnormal cochlear ganglion morphology 0.0672707503551856 0.261363530258807 1.16860528318295 0.434782608695652 3.1 3 1 increased susceptibility to age related obesity 0.0672707503551856 0.261363530258807 1.16860528318295 0.434782608695652 3.1 3 1 decreased epididymis weight 0.0672707503551856 0.261363530258807 1.16860528318295 0.434782608695652 3.1 3 1 decreased effector memory CD8-positive, alpha-beta T cell number 0.0672707503551856 0.261363530258807 1.16860528318295 0.434782608695652 3.1 3 1 neonatal lethality, incomplete penetrance 9.51735716941724e-09 6.31318025571344e-07 1.1681558196125 0.434615384615385 3.1 3 1 abnormal embryo size 0.000143454487619676 0.00257542012718688 1.1655027912807 0.433628318584071 3.1 3 1 respiratory distress 3.01196817141578e-06 9.30716872844319e-05 1.16522781126624 0.433526011560694 3.1 3 1 epidermal hyperplasia 0.00492053508398865 0.0437136822193634 1.16470993223901 0.433333333333333 3.1 3 1 muscular ventricular septal defect 0.00492053508398865 0.0437136822193634 1.16470993223901 0.433333333333333 3.1 3 1 gastrointestinal hemorrhage 0.0407088542207968 0.194737067065831 1.16470993223901 0.433333333333333 3.1 3 1 increased metastatic potential 0.0407088542207968 0.194737067065831 1.16470993223901 0.433333333333333 3.1 3 1 disorganized myocardium 0.0407088542207968 0.194737067065831 1.16470993223901 0.433333333333333 3.1 3 1 cachexia 0.000278159648040178 0.00450763599022764 1.16298698855227 0.432692307692308 3.1 3 1 postnatal lethality, complete penetrance 5.08750130034923e-12 7.0306441581215e-10 1.16285308101185 0.432642487046632 3.1 3 1 increased granulocyte number 0.0020156918227589 0.0221956620476139 1.16228849786845 0.432432432432432 3.1 3 1 abnormal long bone metaphysis morphology 0.025091365740144 0.135979896031826 1.16228849786845 0.432432432432432 3.1 3 1 skin inflammation 0.025091365740144 0.135979896031826 1.16228849786845 0.432432432432432 3.1 3 1 female infertility 1.01549539344165e-08 6.64748629259502e-07 1.16201540376651 0.432330827067669 3.1 3 1 small kidney 0.000836604891736777 0.0111584700707519 1.16063751988853 0.431818181818182 3.1 3 1 impaired glucose tolerance 3.68437071244637e-08 2.15644050522596e-06 1.15965225883599 0.431451612903226 3.1 3 1 increased lung adenocarcinoma incidence 0.00986026701372254 0.0717175853702772 1.15943975155015 0.431372549019608 3.1 3 1 small lung 0.00986026701372254 0.0717175853702772 1.15943975155015 0.431372549019608 3.1 3 1 abnormal thrombosis 0.00986026701372254 0.0717175853702772 1.15943975155015 0.431372549019608 3.1 3 1 microphthalmia 1.39001959518204e-05 0.000377887840766703 1.15943975155015 0.431372549019608 3.1 3 1 dermatitis 0.00625147517024502 0.0506532393680277 1.15853109970724 0.431034482758621 3.1 3 1 thrombocytosis 0.00625147517024502 0.0506532393680277 1.15853109970724 0.431034482758621 3.1 3 1 cochlear outer hair cell degeneration 0.00255080451164789 0.0261654689596872 1.15724384292979 0.430555555555556 3.1 3 1 increased susceptibility to bacterial infection induced morbidity/mortality 0.00255080451164789 0.0261654689596872 1.15724384292979 0.430555555555556 3.1 3 1 abnormal gait 1.05988822895544e-09 8.50474828879567e-08 1.15688141140992 0.43042071197411 3.1 3 1 decreased lymphocyte cell number 7.87468660255528e-05 0.00169595523150271 1.15491069002065 0.4296875 3.1 3 1 increased or absent threshold for auditory brainstem response 4.79071758548482e-09 3.40483142682671e-07 1.15323953897501 0.429065743944637 3.1 3 1 abnormal trabecular bone morphology 0.000151908281349607 0.00268947935841387 1.15191092199463 0.428571428571429 3.1 3 1 abnormal lung morphology 0.000151908281349607 0.00268947935841387 1.15191092199463 0.428571428571429 3.1 3 1 decreased inflammatory response 0.00133183702925035 0.0160433153039237 1.15191092199463 0.428571428571429 3.1 3 1 abnormal vibrissa morphology 0.020014846166559 0.117560637164854 1.15191092199463 0.428571428571429 3.1 3 1 small ears 0.0879158562928518 0.301019535483095 1.15191092199463 0.428571428571429 3.1 3 1 trunk curl 0.0879158562928518 0.301019535483095 1.15191092199463 0.428571428571429 3.1 3 1 left pulmonary isomerism 0.0879158562928518 0.301019535483095 1.15191092199463 0.428571428571429 3.1 3 1 abnormal clavicle morphology 0.0879158562928518 0.301019535483095 1.15191092199463 0.428571428571429 3.1 3 1 vascular ring 0.0879158562928518 0.301019535483095 1.15191092199463 0.428571428571429 3.1 3 1 embryonic lethality at implantation, complete penetrance 0.0879158562928518 0.301019535483095 1.15191092199463 0.428571428571429 3.1 3 1 abnormal respiratory system physiology 0.0125580981013321 0.0866526186603703 1.15191092199463 0.428571428571429 3.1 3 1 decreased urine osmolality 0.0125580981013321 0.0866526186603703 1.15191092199463 0.428571428571429 3.1 3 1 abnormal liver development 0.0322269867027623 0.163768395144272 1.15191092199463 0.428571428571429 3.1 3 1 abnormal midbrain development 0.0322269867027623 0.163768395144272 1.15191092199463 0.428571428571429 3.1 3 1 impaired adaptive thermogenesis 0.0322269867027623 0.163768395144272 1.15191092199463 0.428571428571429 3.1 3 1 shortened head 0.0526449505299675 0.230204739215385 1.15191092199463 0.428571428571429 3.1 3 1 abnormal hormone level 0.0526449505299675 0.230204739215385 1.15191092199463 0.428571428571429 3.1 3 1 abnormal mitotic spindle morphology 0.0526449505299675 0.230204739215385 1.15191092199463 0.428571428571429 3.1 3 1 translucent skin 0.152551204908193 0.426372047425988 1.15191092199463 0.428571428571429 3.1 3 1 irregularly shaped pupil 0.152551204908193 0.426372047425988 1.15191092199463 0.428571428571429 3.1 3 1 increased aggression towards males 0.152551204908193 0.426372047425988 1.15191092199463 0.428571428571429 3.1 3 1 absent visceral yolk sac blood islands 0.152551204908193 0.426372047425988 1.15191092199463 0.428571428571429 3.1 3 1 abnormal fluid regulation 0.152551204908193 0.426372047425988 1.15191092199463 0.428571428571429 3.1 3 1 abnormal olfactory system physiology 0.152551204908193 0.426372047425988 1.15191092199463 0.428571428571429 3.1 3 1 increased hemangioma incidence 0.152551204908193 0.426372047425988 1.15191092199463 0.428571428571429 3.1 3 1 abnormal kidney medulla morphology 0.152551204908193 0.426372047425988 1.15191092199463 0.428571428571429 3.1 3 1 abnormal prepulse inhibition 0.152551204908193 0.426372047425988 1.15191092199463 0.428571428571429 3.1 3 1 intestinal obstruction 0.152551204908193 0.426372047425988 1.15191092199463 0.428571428571429 3.1 3 1 amyloid beta deposits 0.152551204908193 0.426372047425988 1.15191092199463 0.428571428571429 3.1 3 1 premature hair loss 0.152551204908193 0.426372047425988 1.15191092199463 0.428571428571429 3.1 3 1 abnormal viscerocranium morphology 0.152551204908193 0.426372047425988 1.15191092199463 0.428571428571429 3.1 3 1 sternebra fusion 0.152551204908193 0.426372047425988 1.15191092199463 0.428571428571429 3.1 3 1 testis degeneration 0.152551204908193 0.426372047425988 1.15191092199463 0.428571428571429 3.1 3 1 increased leukocyte cell number 3.43861619563252e-05 0.000818522276233101 1.14926285090958 0.427586206896552 3.1 3 1 perinatal lethality, complete penetrance 6.23860012144478e-07 2.58641963368232e-05 1.14830556699621 0.427230046948357 3.1 3 1 abnormal maternal nurturing 0.00639631140666857 0.0514913418255277 1.14561632679247 0.426229508196721 3.1 3 1 abnormal cochlea morphology 0.0100801021778688 0.0722600984652697 1.14480036074775 0.425925925925926 3.1 3 1 abnormal long bone epiphyseal plate proliferative zone 0.0100801021778688 0.0722600984652697 1.14480036074775 0.425925925925926 3.1 3 1 abnormal tibia morphology 0.0159892350663178 0.104391659389673 1.14374134098757 0.425531914893617 3.1 3 1 abnormal cell nucleus morphology 0.0159892350663178 0.104391659389673 1.14374134098757 0.425531914893617 3.1 3 1 abnormal cranium morphology 8.27325688846174e-05 0.0017366857814387 1.14331457183049 0.425373134328358 3.1 3 1 increased total body fat amount 8.27325688846174e-05 0.0017366857814387 1.14331457183049 0.425373134328358 3.1 3 1 decreased circulating phosphate level 0.0255790410093348 0.138171258438046 1.14231166431134 0.425 3.1 3 1 abnormal tail morphology 0.00515565827921956 0.04547765946652 1.1402754581361 0.424242424242424 3.1 3 1 absent vibrissae 0.0413972745887033 0.196894303134607 1.1402754581361 0.424242424242424 3.1 3 1 head tossing 0.0413972745887033 0.196894303134607 1.1402754581361 0.424242424242424 3.1 3 1 syndactyly 0.00809826404389915 0.06085931060181 1.13889497937322 0.423728813559322 3.1 3 1 increased embryonic tissue cell apoptosis 0.00266547679200125 0.0272294600414912 1.13714283325111 0.423076923076923 3.1 3 1 abnormal skin condition 0.0127917191179548 0.0878988986351179 1.13714283325111 0.423076923076923 3.1 3 1 abnormal hair growth 0.0127917191179548 0.0878988986351179 1.13714283325111 0.423076923076923 3.1 3 1 abnormal ureter morphology 0.0681282411430002 0.263264182886926 1.13714283325111 0.423076923076923 3.1 3 1 heart inflammation 0.0681282411430002 0.263264182886926 1.13714283325111 0.423076923076923 3.1 3 1 abnormal ectoderm development 0.0203503243085455 0.118224312026175 1.13484557500211 0.422222222222222 3.1 3 1 abnormal cell migration 0.0203503243085455 0.118224312026175 1.13484557500211 0.422222222222222 3.1 3 1 decreased osteoclast cell number 0.0203503243085455 0.118224312026175 1.13484557500211 0.422222222222222 3.1 3 1 small superior vagus ganglion 0.115125080060099 0.360218410879871 1.13170195845086 0.421052631578947 3.1 3 1 thin dermal layer 0.115125080060099 0.360218410879871 1.13170195845086 0.421052631578947 3.1 3 1 abnormal stationary movement 0.115125080060099 0.360218410879871 1.13170195845086 0.421052631578947 3.1 3 1 abnormal ear morphology 0.115125080060099 0.360218410879871 1.13170195845086 0.421052631578947 3.1 3 1 abnormal neurotransmitter level 0.115125080060099 0.360218410879871 1.13170195845086 0.421052631578947 3.1 3 1 decreased germ cell number 0.115125080060099 0.360218410879871 1.13170195845086 0.421052631578947 3.1 3 1 abnormal optic vesicle formation 0.115125080060099 0.360218410879871 1.13170195845086 0.421052631578947 3.1 3 1 oliguria 0.115125080060099 0.360218410879871 1.13170195845086 0.421052631578947 3.1 3 1 decreased eye pigmentation 0.115125080060099 0.360218410879871 1.13170195845086 0.421052631578947 3.1 3 1 thin interventricular septum 0.115125080060099 0.360218410879871 1.13170195845086 0.421052631578947 3.1 3 1 increased neutrophil cell number 7.01838838464516e-05 0.00153817102262598 1.13072635331427 0.420689655172414 3.1 3 1 abnormal sternum morphology 0.0052405272617214 0.0461305314630035 1.12965177374352 0.420289855072464 3.1 3 1 increased monocyte cell number 0.000912525223693745 0.0119783983848981 1.12887270355473 0.42 3.1 3 1 increased eosinophil cell number 0.00821955011183106 0.0614639805496397 1.12713864410227 0.419354838709677 3.1 3 1 osteopetrosis 0.0531806028032486 0.23066564860171 1.12713864410227 0.419354838709677 3.1 3 1 abnormal cranial ganglia morphology 0.0531806028032486 0.23066564860171 1.12713864410227 0.419354838709677 3.1 3 1 abnormal eyelid morphology 0.0531806028032486 0.23066564860171 1.12713864410227 0.419354838709677 3.1 3 1 increased lung adenoma incidence 0.0531806028032486 0.23066564860171 1.12713864410227 0.419354838709677 3.1 3 1 abnormal capillary morphology 0.0531806028032486 0.23066564860171 1.12713864410227 0.419354838709677 3.1 3 1 decreased thymus weight 0.0531806028032486 0.23066564860171 1.12713864410227 0.419354838709677 3.1 3 1 inner cell mass degeneration 0.0531806028032486 0.23066564860171 1.12713864410227 0.419354838709677 3.1 3 1 abnormal CD8-positive, alpha beta T cell morphology 0.0531806028032486 0.23066564860171 1.12713864410227 0.419354838709677 3.1 3 1 abnormal podocyte morphology 0.0531806028032486 0.23066564860171 1.12713864410227 0.419354838709677 3.1 3 1 abnormal embryo development 0.000134274269660623 0.00246117849892312 1.12650112224475 0.419117647058824 3.1 3 1 hypoactivity 3.35881047399801e-10 2.98394323359644e-08 1.12644870002304 0.419098143236074 3.1 3 1 abnormal left-right axis patterning 0.0258892693367566 0.138941871575366 1.12512229590173 0.418604651162791 3.1 3 1 decreased body size 7.41642940014421e-20 2.63548116183696e-17 1.12496563726961 0.418546365914787 3.1 3 1 decreased compact bone thickness 0.00660051371157133 0.0519581577770053 1.1232564214475 0.417910447761194 3.1 3 1 hunched posture 0.00340210394695919 0.0333178486931535 1.12274862017198 0.417721518987342 3.1 3 1 abnormal nervous system physiology 0.000486839746923745 0.00716576254717643 1.12186107185564 0.417391304347826 3.1 3 1 respiratory failure 7.23740561667403e-05 0.00157921460276111 1.1213967253855 0.417218543046358 3.1 3 1 abnormal inflammatory response 0.00530596561359348 0.0461305314630035 1.11991339638366 0.416666666666667 3.1 3 1 abnormal heart left ventricle morphology 0.00530596561359348 0.0461305314630035 1.11991339638366 0.416666666666667 3.1 3 1 abnormal osteoclast morphology 0.0205659217286475 0.118224312026175 1.11991339638366 0.416666666666667 3.1 3 1 abnormal trophoblast giant cell morphology 0.0417465415017201 0.197612618751036 1.11991339638366 0.416666666666667 3.1 3 1 abnormal foregut morphology 0.0882253011827636 0.301249741512868 1.11991339638366 0.416666666666667 3.1 3 1 curly vibrissae 0.0882253011827636 0.301249741512868 1.11991339638366 0.416666666666667 3.1 3 1 abnormal startle reflex 0.0882253011827636 0.301249741512868 1.11991339638366 0.416666666666667 3.1 3 1 increased circulating total protein level 0.0882253011827636 0.301249741512868 1.11991339638366 0.416666666666667 3.1 3 1 abnormal supraoccipital bone morphology 0.204276799699831 0.497443503919069 1.11991339638366 0.416666666666667 3.1 3 1 abnormal esophagus morphology 0.204276799699831 0.497443503919069 1.11991339638366 0.416666666666667 3.1 3 1 mesocardia 0.204276799699831 0.497443503919069 1.11991339638366 0.416666666666667 3.1 3 1 abnormal superior cervical ganglion morphology 0.204276799699831 0.497443503919069 1.11991339638366 0.416666666666667 3.1 3 1 increased papilloma incidence 0.204276799699831 0.497443503919069 1.11991339638366 0.416666666666667 3.1 3 1 abnormal respiratory function 0.204276799699831 0.497443503919069 1.11991339638366 0.416666666666667 3.1 3 1 abnormal corticospinal tract morphology 0.204276799699831 0.497443503919069 1.11991339638366 0.416666666666667 3.1 3 1 abnormal AMPA-mediated synaptic currents 0.204276799699831 0.497443503919069 1.11991339638366 0.416666666666667 3.1 3 1 dilated bile duct 0.204276799699831 0.497443503919069 1.11991339638366 0.416666666666667 3.1 3 1 increased fear-related response 0.204276799699831 0.497443503919069 1.11991339638366 0.416666666666667 3.1 3 1 absent ovary 0.204276799699831 0.497443503919069 1.11991339638366 0.416666666666667 3.1 3 1 vestibular saccular macula degeneration 0.204276799699831 0.497443503919069 1.11991339638366 0.416666666666667 3.1 3 1 stria vascularis degeneration 0.204276799699831 0.497443503919069 1.11991339638366 0.416666666666667 3.1 3 1 abnormal cochlear outer hair cell physiology 0.204276799699831 0.497443503919069 1.11991339638366 0.416666666666667 3.1 3 1 decreased renal glomerular filtration rate 0.204276799699831 0.497443503919069 1.11991339638366 0.416666666666667 3.1 3 1 decreased keratinocyte proliferation 0.204276799699831 0.497443503919069 1.11991339638366 0.416666666666667 3.1 3 1 hydrometra 0.204276799699831 0.497443503919069 1.11991339638366 0.416666666666667 3.1 3 1 reduced cerebellar foliation 0.204276799699831 0.497443503919069 1.11991339638366 0.416666666666667 3.1 3 1 persistent right dorsal aorta 0.204276799699831 0.497443503919069 1.11991339638366 0.416666666666667 3.1 3 1 increased type II pneumocyte number 0.204276799699831 0.497443503919069 1.11991339638366 0.416666666666667 3.1 3 1 embryonic lethality between implantation and placentation, incomplete penetrance 0.204276799699831 0.497443503919069 1.11991339638366 0.416666666666667 3.1 3 1 abnormal vitelline vein connection 0.204276799699831 0.497443503919069 1.11991339638366 0.416666666666667 3.1 3 1 decreased grip strength 2.60211018703884e-06 8.40616764968718e-05 1.11684514050316 0.415525114155251 3.1 3 1 Leydig cell hyperplasia 0.0329177570022415 0.166028064511919 1.11445040420618 0.414634146341463 3.1 3 1 abnormal spleen morphology 3.21322763638071e-05 0.000776010072378352 1.11218985571895 0.413793103448276 3.1 3 1 abnormal parietal bone morphology 0.0683163939913611 0.263264182886926 1.11218985571895 0.413793103448276 3.1 3 1 aphagia 0.0683163939913611 0.263264182886926 1.11218985571895 0.413793103448276 3.1 3 1 abnormal outer ear morphology 0.0683163939913611 0.263264182886926 1.11218985571895 0.413793103448276 3.1 3 1 short sternum 0.0683163939913611 0.263264182886926 1.11218985571895 0.413793103448276 3.1 3 1 increased double-positive T cell number 0.0683163939913611 0.263264182886926 1.11218985571895 0.413793103448276 3.1 3 1 abnormal spermatogenesis 2.12872409286787e-05 0.000548725510985371 1.11017501902381 0.41304347826087 3.1 3 1 abnormal immune system morphology 0.0260509872418911 0.139209088644907 1.11017501902381 0.41304347826087 3.1 3 1 decreased litter size 1.82443595062362e-07 8.9867018359926e-06 1.10955120837442 0.412811387900356 3.1 3 1 edema 3.98784451040121e-05 0.000935826718832359 1.10949559734754 0.412790697674419 3.1 3 1 neonatal lethality, complete penetrance 3.99902152703624e-11 4.32502871674028e-09 1.10812483431647 0.412280701754386 3.1 3 1 ventricular septal defect 0.000265328981572558 0.00432790715843763 1.1067379446615 0.411764705882353 3.1 3 1 impaired hematopoiesis 0.0206792991696019 0.118224312026175 1.1067379446615 0.411764705882353 3.1 3 1 abnormal direction of heart looping 0.0533010112590093 0.230986525273146 1.1067379446615 0.411764705882353 3.1 3 1 abnormal bone marrow cavity morphology 0.151083661441162 0.426372047425988 1.1067379446615 0.411764705882353 3.1 3 1 decreased vasoconstriction 0.151083661441162 0.426372047425988 1.1067379446615 0.411764705882353 3.1 3 1 abnormal duodenum morphology 0.151083661441162 0.426372047425988 1.1067379446615 0.411764705882353 3.1 3 1 abnormal tarsal bone morphology 0.151083661441162 0.426372047425988 1.1067379446615 0.411764705882353 3.1 3 1 pancytopenia 0.151083661441162 0.426372047425988 1.1067379446615 0.411764705882353 3.1 3 1 increased brain size 0.151083661441162 0.426372047425988 1.1067379446615 0.411764705882353 3.1 3 1 abnormal survival 0.151083661441162 0.426372047425988 1.1067379446615 0.411764705882353 3.1 3 1 abnormal coat/hair pigmentation 0.00095230511773572 0.0123378071894146 1.10391463357818 0.410714285714286 3.1 3 1 abnormal eye development 0.016457395813648 0.106887133384986 1.10391463357818 0.410714285714286 3.1 3 1 decreased startle reflex 0.000770404129662093 0.01035881228397 1.10268395951622 0.41025641025641 3.1 3 1 increased autoantibody level 0.0418263492552444 0.197612618751036 1.10268395951622 0.41025641025641 3.1 3 1 impaired macrophage chemotaxis 0.0418263492552444 0.197612618751036 1.10268395951622 0.41025641025641 3.1 3 1 abnormal response to injury 0.0418263492552444 0.197612618751036 1.10268395951622 0.41025641025641 3.1 3 1 abnormal suckling behavior 0.00348265901978238 0.0337141873402541 1.09955133463123 0.409090909090909 3.1 3 1 osteoporosis 0.0329720055754324 0.166028064511919 1.09955133463123 0.409090909090909 3.1 3 1 decreased macrophage cell number 0.0329720055754324 0.166028064511919 1.09955133463123 0.409090909090909 3.1 3 1 abnormal enterocyte morphology 0.11432247570164 0.360218410879871 1.09955133463123 0.409090909090909 3.1 3 1 abnormal facial nerve morphology 0.11432247570164 0.360218410879871 1.09955133463123 0.409090909090909 3.1 3 1 abnormal chorion morphology 0.11432247570164 0.360218410879871 1.09955133463123 0.409090909090909 3.1 3 1 abnormal lysosome physiology 0.11432247570164 0.360218410879871 1.09955133463123 0.409090909090909 3.1 3 1 decreased cardiac output 0.11432247570164 0.360218410879871 1.09955133463123 0.409090909090909 3.1 3 1 abnormal basement membrane morphology 0.11432247570164 0.360218410879871 1.09955133463123 0.409090909090909 3.1 3 1 abnormal long bone hypertrophic chondrocyte zone 0.0260885587130031 0.139260278537758 1.09705802094726 0.408163265306122 3.1 3 1 embryonic lethality, complete penetrance 8.40916602914633e-08 4.45059585053223e-06 1.09533849426866 0.407523510971787 3.1 3 1 increased circulating alkaline phosphatase level 0.000116367069354156 0.00221379479419526 1.09502643201958 0.407407407407407 3.1 3 1 abnormal axon morphology 0.00147187165860136 0.0172701922206174 1.09502643201958 0.407407407407407 3.1 3 1 abnormal maxilla morphology 0.0207056917745997 0.118224312026175 1.09502643201958 0.407407407407407 3.1 3 1 impaired limb coordination 0.0207056917745997 0.118224312026175 1.09502643201958 0.407407407407407 3.1 3 1 axon degeneration 0.0207056917745997 0.118224312026175 1.09502643201958 0.407407407407407 3.1 3 1 rectal prolapse 0.0877465862374341 0.301019535483095 1.09502643201958 0.407407407407407 3.1 3 1 limb grasping 5.06095533567793e-05 0.00116565985162026 1.09283856702054 0.406593406593407 3.1 3 1 increased grip strength 0.00349211476127 0.0337141873402541 1.09283856702054 0.406593406593407 3.1 3 1 abnormal tooth morphology 0.0131396572860688 0.0888176562475438 1.09191556147407 0.40625 3.1 3 1 abnormal depression-related behavior 0.0680141645525709 0.263264182886926 1.09191556147407 0.40625 3.1 3 1 decreased susceptibility to parasitic infection 0.0680141645525709 0.263264182886926 1.09191556147407 0.40625 3.1 3 1 abnormal T cell differentiation 0.00226597180464791 0.0237831428863362 1.09108394261537 0.405940594059406 3.1 3 1 abnormal pulmonary alveolus morphology 0.00226597180464791 0.0237831428863362 1.09108394261537 0.405940594059406 3.1 3 1 abnormal coat appearance 0.0104989446885229 0.0747242486772556 1.09069826430409 0.405797101449275 3.1 3 1 arrest of spermatogenesis 0.00540584921465951 0.0461305314630035 1.0879158707727 0.404761904761905 3.1 3 1 abnormal cartilage morphology 0.0416917363705054 0.197612618751036 1.0879158707727 0.404761904761905 3.1 3 1 abnormal muscle morphology 0.0416917363705054 0.197612618751036 1.0879158707727 0.404761904761905 3.1 3 1 eyelids open at birth 0.0260224985594271 0.139206376702312 1.08545452264878 0.403846153846154 3.1 3 1 abnormal brain wave pattern 0.0260224985594271 0.139206376702312 1.08545452264878 0.403846153846154 3.1 3 1 increased bone mineral content 0.00182826785051011 0.0206441848149663 1.08498031796436 0.403669724770642 3.1 3 1 decreased susceptibility to induced arthritis 0.0206582212199452 0.118224312026175 1.08454771018208 0.403508771929825 3.1 3 1 maternal effect 0.0131141857040576 0.0887660869084174 1.08314012068151 0.402985074626866 3.1 3 1 hydrops fetalis 0.0104799892102045 0.0746961981672888 1.08258294983754 0.402777777777778 3.1 3 1 abnormal response/metabolism to endogenous compounds 0.00672465691051247 0.0527684039902201 1.0816724511413 0.402439024390244 3.1 3 1 abnormal kidney morphology 0.000143912923690041 0.00257542012718688 1.07511686052832 0.4 3.1 3 1 abnormal testis morphology 0.00182087559834312 0.0206352075210866 1.07511686052832 0.4 3.1 3 1 increased inflammatory response 0.00432309638593112 0.0399765883271512 1.07511686052832 0.4 3.1 3 1 decreased insulin secretion 0.00537874048120991 0.0461305314630035 1.07511686052832 0.4 3.1 3 1 circling 0.00669974348445941 0.0526559618249377 1.07511686052832 0.4 3.1 3 1 decreased circulating calcium level 0.0258700985044902 0.138941871575366 1.07511686052832 0.4 3.1 3 1 abnormal rostral-caudal axis patterning 0.0258700985044902 0.138941871575366 1.07511686052832 0.4 3.1 3 1 abnormal T-helper 2 physiology 0.0258700985044902 0.138941871575366 1.07511686052832 0.4 3.1 3 1 decreased circulating total protein level 0.0258700985044902 0.138941871575366 1.07511686052832 0.4 3.1 3 1 abnormal interventricular septum morphology 0.0326646621376687 0.164981415365382 1.07511686052832 0.4 3.1 3 1 short stride length 0.0326646621376687 0.164981415365382 1.07511686052832 0.4 3.1 3 1 altered response to myocardial infarction 0.0413864597533571 0.196894303134607 1.07511686052832 0.4 3.1 3 1 abnormal hair cycle 0.0867214205050705 0.298780517321832 1.07511686052832 0.4 3.1 3 1 delayed eyelid opening 0.0867214205050705 0.298780517321832 1.07511686052832 0.4 3.1 3 1 abnormal response to new environment 0.0867214205050705 0.298780517321832 1.07511686052832 0.4 3.1 3 1 enhanced paired-pulse facilitation 0.0867214205050705 0.298780517321832 1.07511686052832 0.4 3.1 3 1 increased pre-B cell number 0.112664612356818 0.359068831822658 1.07511686052832 0.4 3.1 3 1 diaphragmatic hernia 0.112664612356818 0.359068831822658 1.07511686052832 0.4 3.1 3 1 decreased acute inflammation 0.112664612356818 0.359068831822658 1.07511686052832 0.4 3.1 3 1 abnormal fontanelle morphology 0.198739544604768 0.497443503919069 1.07511686052832 0.4 3.1 3 1 absent incisors 0.198739544604768 0.497443503919069 1.07511686052832 0.4 3.1 3 1 decreased chondrocyte number 0.198739544604768 0.497443503919069 1.07511686052832 0.4 3.1 3 1 abnormal prostate gland morphology 0.198739544604768 0.497443503919069 1.07511686052832 0.4 3.1 3 1 abnormal pup retrieval 0.198739544604768 0.497443503919069 1.07511686052832 0.4 3.1 3 1 dilated ureter 0.198739544604768 0.497443503919069 1.07511686052832 0.4 3.1 3 1 abnormal olfactory nerve morphology 0.198739544604768 0.497443503919069 1.07511686052832 0.4 3.1 3 1 liver vascular congestion 0.198739544604768 0.497443503919069 1.07511686052832 0.4 3.1 3 1 bicuspid aortic valve 0.198739544604768 0.497443503919069 1.07511686052832 0.4 3.1 3 1 decreased trabecular bone mass 0.198739544604768 0.497443503919069 1.07511686052832 0.4 3.1 3 1 herniated liver 0.198739544604768 0.497443503919069 1.07511686052832 0.4 3.1 3 1 head bobbing 0.0526578880858509 0.230204739215385 1.07511686052832 0.4 3.1 3 1 abnormal artery morphology 0.067350360963174 0.261363530258807 1.07511686052832 0.4 3.1 3 1 abnormal embryonic epiblast morphology 0.067350360963174 0.261363530258807 1.07511686052832 0.4 3.1 3 1 increased urine glucose level 0.148215150279256 0.424997332933314 1.07511686052832 0.4 3.1 3 1 anencephaly 0.148215150279256 0.424997332933314 1.07511686052832 0.4 3.1 3 1 spleen atrophy 0.148215150279256 0.424997332933314 1.07511686052832 0.4 3.1 3 1 abnormal male reproductive system physiology 0.148215150279256 0.424997332933314 1.07511686052832 0.4 3.1 3 1 abnormal induced retinal neovascularization 0.148215150279256 0.424997332933314 1.07511686052832 0.4 3.1 3 1 enhanced behavioral response to xenobiotic 0.148215150279256 0.424997332933314 1.07511686052832 0.4 3.1 3 1 abnormal sperm mitochondrial sheath morphology 0.148215150279256 0.424997332933314 1.07511686052832 0.4 3.1 3 1 abnormal heart electrocardiography waveform feature 0.148215150279256 0.424997332933314 1.07511686052832 0.4 3.1 3 1 decreased bone mineral content 4.10930026868249e-05 0.000959801353835464 1.0725324449982 0.399038461538462 3.1 3 1 polydactyly 0.00430136445446939 0.0398496986238086 1.06963157042358 0.397959183673469 3.1 3 1 abnormal definitive hematopoiesis 0.00535026510252121 0.0461305314630035 1.06933666235343 0.397849462365591 3.1 3 1 lung inflammation 0.000950922565217617 0.0123378071894146 1.06721158949502 0.397058823529412 3.1 3 1 abnormal hair follicle morphology 0.0203853023296199 0.118224312026175 1.06658418703206 0.396825396825397 3.1 3 1 gliosis 0.0203853023296199 0.118224312026175 1.06658418703206 0.396825396825397 3.1 3 1 reduced male fertility 2.68002247197486e-05 0.000673389484751259 1.06564446528137 0.39647577092511 3.1 3 1 abnormal kidney physiology 0.0409455350709162 0.195305883967218 1.06391772656448 0.395833333333333 3.1 3 1 thymus atrophy 0.0409455350709162 0.195305883967218 1.06391772656448 0.395833333333333 3.1 3 1 abnormal hair shaft morphology 0.0409455350709162 0.195305883967218 1.06391772656448 0.395833333333333 3.1 3 1 delayed endochondral bone ossification 0.0520241186618026 0.228236323053323 1.06261550168497 0.395348837209302 3.1 3 1 increased exploration in new environment 0.0102846323098628 0.0734089608917755 1.06184381286747 0.395061728395062 3.1 3 1 seizures 0.00275116590828593 0.0278566085454293 1.06097058604768 0.394736842105263 3.1 3 1 abnormal reproductive system physiology 0.0664194002653694 0.261363530258807 1.06097058604768 0.394736842105263 3.1 3 1 abnormal retinal outer nuclear layer morphology 0.0664194002653694 0.261363530258807 1.06097058604768 0.394736842105263 3.1 3 1 abnormal skin morphology 0.0201779562679483 0.118224312026175 1.05882721112637 0.393939393939394 3.1 3 1 abnormal tooth development 0.0853151430290846 0.297854622154172 1.05882721112637 0.393939393939394 3.1 3 1 belly spot 0.0853151430290846 0.297854622154172 1.05882721112637 0.393939393939394 3.1 3 1 abnormal QRS complex 0.0853151430290846 0.297854622154172 1.05882721112637 0.393939393939394 3.1 3 1 cardiovascular system phenotype 0.0853151430290846 0.297854622154172 1.05882721112637 0.393939393939394 3.1 3 1 abnormal long bone morphology 0.0253624187228923 0.137150036028684 1.05749199396228 0.39344262295082 3.1 3 1 increased double-negative T cell number 0.0253624187228923 0.137150036028684 1.05749199396228 0.39344262295082 3.1 3 1 decreased exploration in new environment 0.0101827837651755 0.0728911499737379 1.05591834516174 0.392857142857143 3.1 3 1 abnormal neuron differentiation 0.00338319219414505 0.0331979904652301 1.05591834516174 0.392857142857143 3.1 3 1 abnormal spleen germinal center morphology 0.110459409342266 0.355226607290093 1.05591834516174 0.392857142857143 3.1 3 1 increased bone resorption 0.110459409342266 0.355226607290093 1.05591834516174 0.392857142857143 3.1 3 1 abnormal response to infection 0.0127170813433671 0.0876280882039489 1.05470324925246 0.392405063291139 3.1 3 1 abnormal behavior 7.39950766150019e-06 0.00021035743209122 1.05384656292794 0.392086330935252 3.1 3 1 increased lymphocyte cell number 0.0199333665349519 0.117224982318735 1.05174475486466 0.391304347826087 3.1 3 1 abnormal inner ear morphology 0.0512449777964424 0.225215339697262 1.05174475486466 0.391304347826087 3.1 3 1 abnormal lymphocyte physiology 0.0512449777964424 0.225215339697262 1.05174475486466 0.391304347826087 3.1 3 1 abnormal cranial nerve morphology 0.144570013424361 0.418553278123071 1.05174475486466 0.391304347826087 3.1 3 1 failure of embryo implantation 0.144570013424361 0.418553278123071 1.05174475486466 0.391304347826087 3.1 3 1 abnormal nasal cavity morphology 0.144570013424361 0.418553278123071 1.05174475486466 0.391304347826087 3.1 3 1 abnormal Wolffian duct morphology 0.144570013424361 0.418553278123071 1.05174475486466 0.391304347826087 3.1 3 1 dilated heart 0.144570013424361 0.418553278123071 1.05174475486466 0.391304347826087 3.1 3 1 cyanosis 0.000206300295124305 0.00345570359677918 1.04991880910969 0.390625 3.1 3 1 decreased eosinophil cell number 0.0250299465883065 0.135943214276009 1.04991880910969 0.390625 3.1 3 1 increased tumor growth/size 0.0652915719793613 0.261363530258807 1.04889449807641 0.390243902439024 3.1 3 1 increased circulating glucose level 0.00139473747524077 0.0167604322205866 1.04842956257194 0.390070921985816 3.1 3 1 abnormal thoracic vertebrae morphology 0.0315044516267255 0.160588777503032 1.04778338102336 0.389830508474576 3.1 3 1 abnormal reflex 0.083643700620463 0.29284124601464 1.04525250329142 0.388888888888889 3.1 3 1 short radius 0.083643700620463 0.29284124601464 1.04525250329142 0.388888888888889 3.1 3 1 lowered ear position 0.192211711280418 0.492152992084446 1.04525250329142 0.388888888888889 3.1 3 1 abnormal heart shape 0.192211711280418 0.492152992084446 1.04525250329142 0.388888888888889 3.1 3 1 underdeveloped hair follicles 0.192211711280418 0.492152992084446 1.04525250329142 0.388888888888889 3.1 3 1 abnormal stomach glandular epithelium morphology 0.192211711280418 0.492152992084446 1.04525250329142 0.388888888888889 3.1 3 1 absent ureter 0.192211711280418 0.492152992084446 1.04525250329142 0.388888888888889 3.1 3 1 absent inner cell mass 0.192211711280418 0.492152992084446 1.04525250329142 0.388888888888889 3.1 3 1 abnormal anterior eye segment morphology 0.192211711280418 0.492152992084446 1.04525250329142 0.388888888888889 3.1 3 1 increased anxiety-related response 0.0017045046957967 0.0194493368385059 1.04417824583686 0.388489208633094 3.1 3 1 increased heart weight 0.0017045046957967 0.0194493368385059 1.04417824583686 0.388489208633094 3.1 3 1 enlarged heart 6.9299267262856e-05 0.00152550378156066 1.04267798973652 0.387931034482759 3.1 3 1 increased fluid intake 0.0503549534309279 0.221695480813156 1.0422051198999 0.387755102040816 3.1 3 1 abnormal posture 0.0154762918638763 0.101710108352424 1.04151945863681 0.3875 3.1 3 1 impaired coordination 1.57551068828648e-06 5.53370124443256e-05 1.04093684473118 0.38728323699422 3.1 3 1 absent mature ovarian follicles 0.107905094843064 0.347461389543198 1.04043567147902 0.387096774193548 3.1 3 1 abnormal nose morphology 0.107905094843064 0.347461389543198 1.04043567147902 0.387096774193548 3.1 3 1 decreased neuronal precursor cell number 0.107905094843064 0.347461389543198 1.04043567147902 0.387096774193548 3.1 3 1 small cranium 0.107905094843064 0.347461389543198 1.04043567147902 0.387096774193548 3.1 3 1 no abnormal phenotype detected 4.16259508337729e-27 5.17722763495051e-24 1.03948618647623 0.386743515850144 3.1 3 1 teratozoospermia 0.0122100188463273 0.0847575475253363 1.03846514937394 0.386363636363636 3.1 3 1 hypertension 0.0640198935680359 0.257685251214384 1.03846514937394 0.386363636363636 3.1 3 1 omphalocele 0.0640198935680359 0.257685251214384 1.03846514937394 0.386363636363636 3.1 3 1 abnormal photoreceptor outer segment morphology 0.0640198935680359 0.257685251214384 1.03846514937394 0.386363636363636 3.1 3 1 small ovary 0.0120157274606942 0.0844893732731362 1.03376621204646 0.384615384615385 3.1 3 1 increased urine protein level 0.0190343067261791 0.117224982318735 1.03376621204646 0.384615384615385 3.1 3 1 abnormal female meiosis 0.0493813142599464 0.219890440658857 1.03376621204646 0.384615384615385 3.1 3 1 ventricular hypoplasia 0.140499844365454 0.416807826904076 1.03376621204646 0.384615384615385 3.1 3 1 small seminal vesicle 0.140499844365454 0.416807826904076 1.03376621204646 0.384615384615385 3.1 3 1 increased susceptibility to otitis media 0.140499844365454 0.416807826904076 1.03376621204646 0.384615384615385 3.1 3 1 abnormal tectorial membrane morphology 0.140499844365454 0.416807826904076 1.03376621204646 0.384615384615385 3.1 3 1 absent teeth 0.262065324302813 0.533430470893258 1.03376621204646 0.384615384615385 3.1 3 1 abnormal mast cell morphology 0.262065324302813 0.533430470893258 1.03376621204646 0.384615384615385 3.1 3 1 small trigeminal ganglion 0.262065324302813 0.533430470893258 1.03376621204646 0.384615384615385 3.1 3 1 excessive scratching 0.262065324302813 0.533430470893258 1.03376621204646 0.384615384615385 3.1 3 1 abnormal digestion 0.262065324302813 0.533430470893258 1.03376621204646 0.384615384615385 3.1 3 1 lymphoid hypoplasia 0.262065324302813 0.533430470893258 1.03376621204646 0.384615384615385 3.1 3 1 abnormal lung interstitium morphology 0.262065324302813 0.533430470893258 1.03376621204646 0.384615384615385 3.1 3 1 dystrophic cardiac calcinosis 0.262065324302813 0.533430470893258 1.03376621204646 0.384615384615385 3.1 3 1 absent lateral semicircular canal 0.262065324302813 0.533430470893258 1.03376621204646 0.384615384615385 3.1 3 1 decreased endocochlear potential 0.262065324302813 0.533430470893258 1.03376621204646 0.384615384615385 3.1 3 1 increased renin activity 0.262065324302813 0.533430470893258 1.03376621204646 0.384615384615385 3.1 3 1 abnormal gut flora balance 0.262065324302813 0.533430470893258 1.03376621204646 0.384615384615385 3.1 3 1 small testis 2.74788613261921e-05 0.000683536675489027 1.03226800014494 0.384057971014493 3.1 3 1 abnormal neuron morphology 0.0094952896795475 0.0700876352459181 1.03167779545647 0.383838383838384 3.1 3 1 increased T cell proliferation 0.00751595628686473 0.0571814924243845 1.02990166545937 0.383177570093458 3.1 3 1 abnormal innervation 0.0626447955248263 0.256311704662904 1.02936720688882 0.382978723404255 3.1 3 1 increased systemic arterial blood pressure 0.0626447955248263 0.256311704662904 1.02936720688882 0.382978723404255 3.1 3 1 neuron degeneration 0.0626447955248263 0.256311704662904 1.02936720688882 0.382978723404255 3.1 3 1 decreased osteoblast cell number 0.105133415077226 0.340537088889863 1.02768523432854 0.382352941176471 3.1 3 1 abnormal axial skeleton morphology 0.0233695983656816 0.128326436941795 1.02560489984609 0.381578947368421 3.1 3 1 abnormal pancreas morphology 0.0798145477386569 0.281415574060821 1.02392081955078 0.380952380952381 3.1 3 1 abnormal spleen white pulp morphology 0.0798145477386569 0.281415574060821 1.02392081955078 0.380952380952381 3.1 3 1 hypoalgesia 0.185322408117044 0.476967915355557 1.02392081955078 0.380952380952381 3.1 3 1 decreased cochlear outer hair cell number 0.185322408117044 0.476967915355557 1.02392081955078 0.380952380952381 3.1 3 1 increased acute inflammation 0.185322408117044 0.476967915355557 1.02392081955078 0.380952380952381 3.1 3 1 hyperactivity 2.86529964132724e-06 8.96532434943585e-05 1.0215059119575 0.380053908355795 3.1 3 1 male infertility 6.06226136252817e-08 3.34128539666523e-06 1.02061292425899 0.379721669980119 3.1 3 1 abnormal embryonic neuroepithelium morphology 0.047265635715255 0.218537674426946 1.01950736774237 0.379310344827586 3.1 3 1 lordosis 0.13621347427893 0.405300259890955 1.01950736774237 0.379310344827586 3.1 3 1 abnormal circulating glucose level 0.13621347427893 0.405300259890955 1.01950736774237 0.379310344827586 3.1 3 1 decreased granulocyte number 0.13621347427893 0.405300259890955 1.01950736774237 0.379310344827586 3.1 3 1 focal hair loss 0.13621347427893 0.405300259890955 1.01950736774237 0.379310344827586 3.1 3 1 abnormal spinal nerve morphology 0.13621347427893 0.405300259890955 1.01950736774237 0.379310344827586 3.1 3 1 stomach inflammation 0.13621347427893 0.405300259890955 1.01950736774237 0.379310344827586 3.1 3 1 increased susceptibility to induced arthritis 0.13621347427893 0.405300259890955 1.01950736774237 0.379310344827586 3.1 3 1 decreased T cell number 0.00182996693535681 0.0206441848149663 1.018356032488 0.37888198757764 3.1 3 1 decreased T cell proliferation 0.00283152916009882 0.0284582981242255 1.0170024356349 0.378378378378378 3.1 3 1 abnormal T cell activation 0.0286385490582341 0.150133594904863 1.0170024356349 0.378378378378378 3.1 3 1 increased white adipose tissue amount 0.102234092119755 0.339076405530521 1.0170024356349 0.378378378378378 3.1 3 1 abnormal vocalization 0.102234092119755 0.339076405530521 1.0170024356349 0.378378378378378 3.1 3 1 decreased width of hypertrophic chondrocyte zone 0.102234092119755 0.339076405530521 1.0170024356349 0.378378378378378 3.1 3 1 abnormal pancreatic beta cell physiology 0.102234092119755 0.339076405530521 1.0170024356349 0.378378378378378 3.1 3 1 abnormal humerus morphology 0.102234092119755 0.339076405530521 1.0170024356349 0.378378378378378 3.1 3 1 abnormal cartilage development 0.0777616212412339 0.274566405731113 1.01538814605452 0.377777777777778 3.1 3 1 cardiomyopathy 0.0777616212412339 0.274566405731113 1.01538814605452 0.377777777777778 3.1 3 1 cardiac hypertrophy 0.0138626339059409 0.0935774812510934 1.01477866937622 0.377551020408163 3.1 3 1 abnormal coat/ hair morphology 0.0597017941430879 0.254949721769839 1.01426118917766 0.377358490566038 3.1 3 1 abnormal NK cell physiology 0.0461548888844535 0.215241820391394 1.01342982754719 0.377049180327869 3.1 3 1 abnormal seminiferous tubule morphology 0.00342411037905891 0.0334018610506237 1.01252444056605 0.376712328767123 3.1 3 1 abnormal lens morphology 0.00656506242317125 0.0517609913712789 1.0079220567453 0.375 3.1 3 1 abnormal intestinal epithelium morphology 0.0756643517971722 0.270813057691318 1.0079220567453 0.375 3.1 3 1 abnormal phalanx morphology 0.0756643517971722 0.270813057691318 1.0079220567453 0.375 3.1 3 1 abnormal vertebral body morphology 0.131839653017359 0.394409064198052 1.0079220567453 0.375 3.1 3 1 abnormal lumbar vertebrae morphology 0.131839653017359 0.394409064198052 1.0079220567453 0.375 3.1 3 1 pancreatic islet hyperplasia 0.131839653017359 0.394409064198052 1.0079220567453 0.375 3.1 3 1 abnormal nursing 0.178376840769319 0.466049820102856 1.0079220567453 0.375 3.1 3 1 apnea 0.178376840769319 0.466049820102856 1.0079220567453 0.375 3.1 3 1 blindness 0.178376840769319 0.466049820102856 1.0079220567453 0.375 3.1 3 1 decreased ovulation rate 0.178376840769319 0.466049820102856 1.0079220567453 0.375 3.1 3 1 abnormal tumor morphology 0.178376840769319 0.466049820102856 1.0079220567453 0.375 3.1 3 1 abnormal retinal ganglion layer morphology 0.178376840769319 0.466049820102856 1.0079220567453 0.375 3.1 3 1 hypopigmentation 0.178376840769319 0.466049820102856 1.0079220567453 0.375 3.1 3 1 abnormal tympanic ring morphology 0.249239013946561 0.533430470893258 1.0079220567453 0.375 3.1 3 1 abnormal bone marrow cell number 0.249239013946561 0.533430470893258 1.0079220567453 0.375 3.1 3 1 delayed hair appearance 0.249239013946561 0.533430470893258 1.0079220567453 0.375 3.1 3 1 disorganized retinal layers 0.249239013946561 0.533430470893258 1.0079220567453 0.375 3.1 3 1 white spotting 0.249239013946561 0.533430470893258 1.0079220567453 0.375 3.1 3 1 large intestinal inflammation 0.249239013946561 0.533430470893258 1.0079220567453 0.375 3.1 3 1 increased thymus weight 0.249239013946561 0.533430470893258 1.0079220567453 0.375 3.1 3 1 abnormal level of surface class II molecules 0.249239013946561 0.533430470893258 1.0079220567453 0.375 3.1 3 1 abnormal pancreatic alpha cell morphology 0.249239013946561 0.533430470893258 1.0079220567453 0.375 3.1 3 1 short mandible 0.0581768087958433 0.248722031535902 1.0079220567453 0.375 3.1 3 1 hydroencephaly 0.0102504843590246 0.0732703443766487 1.00500054353734 0.373913043478261 3.1 3 1 infertility 0.0129799515316494 0.0886733589255141 1.00478211264329 0.373831775700935 3.1 3 1 abnormal B cell differentiation 0.0209441608045099 0.118224312026175 1.00423003455942 0.373626373626374 3.1 3 1 abnormal femur morphology 0.0438842816838157 0.205385043628394 1.00290751914955 0.373134328358209 3.1 3 1 abnormal dendritic spine morphology 0.0735475299501139 0.263615966499868 1.00133433088422 0.372549019607843 3.1 3 1 dehydration 0.0427408220098423 0.201526491911996 0.99832279906201 0.371428571428571 3.1 3 1 abnormal intestinal goblet cell morphology 0.12745976523553 0.382225637158989 0.99832279906201 0.371428571428571 3.1 3 1 abnormal hippocampus pyramidal cell morphology 0.12745976523553 0.382225637158989 0.99832279906201 0.371428571428571 3.1 3 1 decreased bone volume 0.12745976523553 0.382225637158989 0.99832279906201 0.371428571428571 3.1 3 1 abnormal neuronal precursor proliferation 0.0714298248300628 0.263615966499868 0.995478574563258 0.37037037037037 3.1 3 1 abnormal heart valve morphology 0.171531172676054 0.466049820102856 0.995478574563258 0.37037037037037 3.1 3 1 decreased double-positive T cell number 0.0194552300018236 0.117224982318735 0.994483095988694 0.37 3.1 3 1 seminiferous tubule degeneration 0.0416002951946906 0.197612618751036 0.994114905283034 0.36986301369863 3.1 3 1 abnormal allantois morphology 0.0933058605019736 0.311332431923084 0.993314490705511 0.369565217391304 3.1 3 1 abnormal facial morphology 0.0693253244152328 0.263615966499868 0.990239213644504 0.368421052631579 3.1 3 1 abnormal compact bone morphology 0.12312599570148 0.381743449678378 0.990239213644504 0.368421052631579 3.1 3 1 hyporesponsive to tactile stimuli 0.12312599570148 0.381743449678378 0.990239213644504 0.368421052631579 3.1 3 1 decreased total retina thickness 0.12312599570148 0.381743449678378 0.990239213644504 0.368421052631579 3.1 3 1 abnormal neural crest cell migration 0.237178912825604 0.533430470893258 0.990239213644504 0.368421052631579 3.1 3 1 abnormal metatarsal bone morphology 0.237178912825604 0.533430470893258 0.990239213644504 0.368421052631579 3.1 3 1 abnormal digestive system development 0.237178912825604 0.533430470893258 0.990239213644504 0.368421052631579 3.1 3 1 osteoarthritis 0.237178912825604 0.533430470893258 0.990239213644504 0.368421052631579 3.1 3 1 abnormal photoreceptor inner segment morphology 0.237178912825604 0.533430470893258 0.990239213644504 0.368421052631579 3.1 3 1 increased left ventricle weight 0.237178912825604 0.533430470893258 0.990239213644504 0.368421052631579 3.1 3 1 abnormal sternebra morphology 0.237178912825604 0.533430470893258 0.990239213644504 0.368421052631579 3.1 3 1 decreased circulating magnesium level 0.237178912825604 0.533430470893258 0.990239213644504 0.368421052631579 3.1 3 1 increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 0.237178912825604 0.533430470893258 0.990239213644504 0.368421052631579 3.1 3 1 shortened RR interval 0.237178912825604 0.533430470893258 0.990239213644504 0.368421052631579 3.1 3 1 decreased food intake 0.0393462453034045 0.189494259810685 0.98665787833295 0.367088607594937 3.1 3 1 increased susceptibility to parasitic infection 0.0299218976708775 0.15330735418395 0.985523788817625 0.366666666666667 3.1 3 1 scaly skin 0.11887192777773 0.37124158235669 0.983338591946633 0.365853658536585 3.1 3 1 short humerus 0.11887192777773 0.37124158235669 0.983338591946633 0.365853658536585 3.1 3 1 absent corpus luteum 0.0874614117111192 0.300913224939708 0.982077901444137 0.365384615384615 3.1 3 1 decreased body temperature 0.0874614117111192 0.300913224939708 0.982077901444137 0.365384615384615 3.1 3 1 abnormal cytokine secretion 0.00741677394972538 0.0570300624418606 0.977378964116653 0.363636363636364 3.1 3 1 abnormal circadian rhythm 0.114718982489733 0.360218410879871 0.977378964116653 0.363636363636364 3.1 3 1 abnormal basisphenoid bone morphology 0.225893798068703 0.533430470893258 0.977378964116653 0.363636363636364 3.1 3 1 intestinal ulcer 0.225893798068703 0.533430470893258 0.977378964116653 0.363636363636364 3.1 3 1 intestinal inflammation 0.225893798068703 0.533430470893258 0.977378964116653 0.363636363636364 3.1 3 1 abnormal oogenesis 0.225893798068703 0.533430470893258 0.977378964116653 0.363636363636364 3.1 3 1 abnormal tracheal cartilage morphology 0.225893798068703 0.533430470893258 0.977378964116653 0.363636363636364 3.1 3 1 abnormal retinal layer morphology 0.225893798068703 0.533430470893258 0.977378964116653 0.363636363636364 3.1 3 1 abnormal temporal bone morphology 0.225893798068703 0.533430470893258 0.977378964116653 0.363636363636364 3.1 3 1 impaired humoral immune response 0.225893798068703 0.533430470893258 0.977378964116653 0.363636363636364 3.1 3 1 abnormal T cell subpopulation ratio 0.158425087296372 0.44254060039273 0.977378964116653 0.363636363636364 3.1 3 1 abnormal social investigation 0.0461634215794206 0.215241820391394 0.974324654853788 0.3625 3.1 3 1 abnormal humoral immune response 0.0259466546081132 0.139099791676038 0.97272477857324 0.361904761904762 3.1 3 1 testicular atrophy 0.106764173567021 0.344903742529823 0.967605174475487 0.36 3.1 3 1 decreased oocyte number 0.106764173567021 0.344903742529823 0.967605174475487 0.36 3.1 3 1 increased cellular sensitivity to ionizing radiation 0.215339969251351 0.51629703471107 0.967605174475487 0.36 3.1 3 1 increased startle reflex 0.0420715658302296 0.198582580650277 0.966397178002983 0.359550561797753 3.1 3 1 increased rib number 0.0555877190244346 0.240686598909106 0.964848464576696 0.358974358974359 3.1 3 1 failure of heart looping 0.146274121292159 0.421374495326282 0.964848464576696 0.358974358974359 3.1 3 1 decreased B-1 B cell number 0.146274121292159 0.421374495326282 0.964848464576696 0.358974358974359 3.1 3 1 azoospermia 0.00965274496192855 0.0705174833856014 0.963548129718776 0.358490566037736 3.1 3 1 domed cranium 0.071479374736053 0.263615966499868 0.959925768328855 0.357142857142857 3.1 3 1 reddish skin 0.205459930083714 0.497728730729011 0.959925768328855 0.357142857142857 3.1 3 1 abnormal ovulation 0.205459930083714 0.497728730729011 0.959925768328855 0.357142857142857 3.1 3 1 abnormal interparietal bone morphology 0.322906501744268 0.583530637914179 0.959925768328855 0.357142857142857 3.1 3 1 absent atrioventricular cushions 0.322906501744268 0.583530637914179 0.959925768328855 0.357142857142857 3.1 3 1 abnormal pinna reflex 0.322906501744268 0.583530637914179 0.959925768328855 0.357142857142857 3.1 3 1 extended life span 0.322906501744268 0.583530637914179 0.959925768328855 0.357142857142857 3.1 3 1 abnormal antigen presentation 0.322906501744268 0.583530637914179 0.959925768328855 0.357142857142857 3.1 3 1 abnormal spleen periarteriolar lymphoid sheath morphology 0.322906501744268 0.583530637914179 0.959925768328855 0.357142857142857 3.1 3 1 decreased coping response 0.322906501744268 0.583530637914179 0.959925768328855 0.357142857142857 3.1 3 1 abnormal uterus development 0.322906501744268 0.583530637914179 0.959925768328855 0.357142857142857 3.1 3 1 abnormal glucose tolerance 0.322906501744268 0.583530637914179 0.959925768328855 0.357142857142857 3.1 3 1 increased pulmonary respiratory rate 0.322906501744268 0.583530637914179 0.959925768328855 0.357142857142857 3.1 3 1 decreased compact bone area 0.322906501744268 0.583530637914179 0.959925768328855 0.357142857142857 3.1 3 1 abnormal motor capabilities/coordination/movement 0.019818058834372 0.117224982318735 0.957016902364223 0.356060606060606 3.1 3 1 increased hemoglobin content 0.095776722260365 0.319148823339126 0.956671782673504 0.355932203389831 3.1 3 1 abnormal autopod morphology 0.135109250764767 0.403704818351182 0.955659431580727 0.355555555555556 3.1 3 1 increased circulating corticosterone level 0.135109250764767 0.403704818351182 0.955659431580727 0.355555555555556 3.1 3 1 abnormal eye electrophysiology 0.0258019662243978 0.138941871575366 0.955165805841275 0.355371900826446 3.1 3 1 decreased double-negative T cell number 0.196195689118357 0.497443503919069 0.953732698855766 0.354838709677419 3.1 3 1 preaxial polydactyly 0.196195689118357 0.497443503919069 0.953732698855766 0.354838709677419 3.1 3 1 decreased susceptibility to bacterial infection induced morbidity/mortality 0.196195689118357 0.497443503919069 0.953732698855766 0.354838709677419 3.1 3 1 abnormal intestine physiology 0.196195689118357 0.497443503919069 0.953732698855766 0.354838709677419 3.1 3 1 abnormal motor coordination/ balance 0.044180410399829 0.206576636972885 0.950229548446746 0.353535353535354 3.1 3 1 abnormal cardiovascular system physiology 0.0227617134689678 0.125126546417806 0.949821286556973 0.353383458646617 3.1 3 1 abnormal gastrulation 0.124882342812607 0.381743449678378 0.948632523995575 0.352941176470588 3.1 3 1 abnormal cervical vertebrae morphology 0.124882342812607 0.381743449678378 0.948632523995575 0.352941176470588 3.1 3 1 decreased susceptibility to injury 0.0859150415479393 0.298686109348725 0.948632523995575 0.352941176470588 3.1 3 1 abnormal vision 0.187493272143179 0.481807349644792 0.948632523995575 0.352941176470588 3.1 3 1 increased width of hypertrophic chondrocyte zone 0.187493272143179 0.481807349644792 0.948632523995575 0.352941176470588 3.1 3 1 abnormal skin physiology 0.187493272143179 0.481807349644792 0.948632523995575 0.352941176470588 3.1 3 1 hydroureter 0.302778297131324 0.551968496968976 0.948632523995575 0.352941176470588 3.1 3 1 abnormal vagus nerve morphology 0.302778297131324 0.551968496968976 0.948632523995575 0.352941176470588 3.1 3 1 abnormal touch/ nociception 0.302778297131324 0.551968496968976 0.948632523995575 0.352941176470588 3.1 3 1 nephrocalcinosis 0.302778297131324 0.551968496968976 0.948632523995575 0.352941176470588 3.1 3 1 abnormal ectoplacental cone morphology 0.302778297131324 0.551968496968976 0.948632523995575 0.352941176470588 3.1 3 1 decreased growth hormone level 0.302778297131324 0.551968496968976 0.948632523995575 0.352941176470588 3.1 3 1 coloboma 0.302778297131324 0.551968496968976 0.948632523995575 0.352941176470588 3.1 3 1 abnormal circulating chemokine level 0.302778297131324 0.551968496968976 0.948632523995575 0.352941176470588 3.1 3 1 common atrium 0.302778297131324 0.551968496968976 0.948632523995575 0.352941176470588 3.1 3 1 delayed heart development 0.302778297131324 0.551968496968976 0.948632523995575 0.352941176470588 3.1 3 1 increased T cell number 0.0581934562226714 0.248722031535902 0.946835871488008 0.352272727272727 3.1 3 1 abnormal CD4-positive, alpha-beta T cell physiology 0.0828656646048708 0.291939224406317 0.946405687084787 0.352112676056338 3.1 3 1 decreased circulating chloride level 0.179303974187458 0.466049820102856 0.944359404518118 0.351351351351351 3.1 3 1 abnormal calcium ion homeostasis 0.179303974187458 0.466049820102856 0.944359404518118 0.351351351351351 3.1 3 1 decreased IgG level 0.0387001618270091 0.186563280125359 0.944359404518117 0.351351351351351 3.1 3 1 impaired ovarian folliculogenesis 0.171584378135441 0.466049820102856 0.940727252962278 0.35 3.1 3 1 small gonad 0.285082477273637 0.54504886874125 0.940727252962278 0.35 3.1 3 1 brain inflammation 0.285082477273637 0.54504886874125 0.940727252962278 0.35 3.1 3 1 abnormal hyoid bone morphology 0.285082477273637 0.54504886874125 0.940727252962278 0.35 3.1 3 1 increased urine calcium level 0.285082477273637 0.54504886874125 0.940727252962278 0.35 3.1 3 1 abnormal circulating cytokine level 0.285082477273637 0.54504886874125 0.940727252962278 0.35 3.1 3 1 decreased B cell number 0.00803070115214126 0.0604428717577954 0.939422499490764 0.349514563106796 3.1 3 1 impaired swimming 0.102932723562006 0.340537088889863 0.936654840611792 0.348484848484849 3.1 3 1 decreased rib number 0.0668103286738041 0.261363530258807 0.936197266190389 0.348314606741573 3.1 3 1 hyperkeratosis 0.0990880738907 0.329961959575791 0.934884226546364 0.347826086956522 3.1 3 1 abnormal blood vessel physiology 0.269266483212352 0.533430470893258 0.934884226546364 0.347826086956522 3.1 3 1 bidirectional circling 0.269266483212352 0.533430470893258 0.934884226546364 0.347826086956522 3.1 3 1 abnormal postnatal growth 0.269266483212352 0.533430470893258 0.934884226546364 0.347826086956522 3.1 3 1 pancreas inflammation 0.269266483212352 0.533430470893258 0.934884226546364 0.347826086956522 3.1 3 1 abnormal B cell morphology 0.269266483212352 0.533430470893258 0.934884226546364 0.347826086956522 3.1 3 1 abnormal ulna morphology 0.269266483212352 0.533430470893258 0.934884226546364 0.347826086956522 3.1 3 1 abnormal neuromuscular synapse morphology 0.0954049597078857 0.318123106264565 0.933261163653054 0.347222222222222 3.1 3 1 abnormal immune system physiology 0.0386101620640293 0.186309947884137 0.932056955699953 0.346774193548387 3.1 3 1 abnormal ocular fundus morphology 0.254961211838002 0.533430470893258 0.930389590841814 0.346153846153846 3.1 3 1 decreased Peyer's patch number 0.254961211838002 0.533430470893258 0.930389590841814 0.346153846153846 3.1 3 1 abnormal middle ear morphology 0.241905433138864 0.533430470893258 0.926824879765792 0.344827586206897 3.1 3 1 retinal degeneration 0.0708954309480181 0.263615966499868 0.923928552016524 0.34375 3.1 3 1 increased circulating follicle stimulating hormone level 0.22990599374269 0.533430470893258 0.923928552016524 0.34375 3.1 3 1 increased dopamine level 0.22990599374269 0.533430470893258 0.923928552016524 0.34375 3.1 3 1 neonatal lethality 0.22990599374269 0.533430470893258 0.923928552016524 0.34375 3.1 3 1 decreased threshold for auditory brainstem response 0.208516523000166 0.500178255509077 0.919507841241325 0.342105263157895 3.1 3 1 short ulna 0.198916759802403 0.497443503919069 0.917782685816857 0.341463414634146 3.1 3 1 short femur 0.0899919616492752 0.306289481150264 0.916292778859362 0.340909090909091 3.1 3 1 abnormal rib morphology 0.0445608780188855 0.208159970088221 0.915840288598197 0.340740740740741 3.1 3 1 decreased bone trabecula number 0.181519968108829 0.467907689814208 0.914993072790058 0.340425531914894 3.1 3 1 abnormal axon extension 0.173605261023453 0.466049820102856 0.913849331449071 0.34 3.1 3 1 irregular heartbeat 0.217354143837542 0.520875176103937 0.895930717106932 0.333333333333333 3.1 3 1 thin epidermis 0.296676231418976 0.54504886874125 0.895930717106932 0.333333333333333 3.1 3 1 salivary gland inflammation 0.280424765423766 0.54504886874125 0.895930717106932 0.333333333333333 3.1 3 1 emphysema 0.280424765423766 0.54504886874125 0.895930717106932 0.333333333333333 3.1 3 1 abnormal palate morphology 0.296676231418976 0.54504886874125 0.895930717106932 0.333333333333333 3.1 3 1 abnormal malleus morphology 0.314711304433869 0.571627871324753 0.895930717106932 0.333333333333333 3.1 3 1 increased stereotypic behavior 0.314711304433869 0.571627871324753 0.895930717106932 0.333333333333333 3.1 3 1 small lymph nodes 0.314711304433869 0.571627871324753 0.895930717106932 0.333333333333333 3.1 3 1 prolonged QT interval 0.314711304433869 0.571627871324753 0.895930717106932 0.333333333333333 3.1 3 1 decreased vocalization 0.334962511851933 0.604219904446472 0.895930717106932 0.333333333333333 3.1 3 1 macrocytosis 0.384989980314018 0.670162754395466 0.895930717106932 0.333333333333333 3.1 3 1 abnormal enteric neuron morphology 0.384989980314018 0.670162754395466 0.895930717106932 0.333333333333333 3.1 3 1 vagina atresia 0.384989980314018 0.670162754395466 0.895930717106932 0.333333333333333 3.1 3 1 absent egg cylinders 0.384989980314018 0.670162754395466 0.895930717106932 0.333333333333333 3.1 3 1 abnormal cricoid cartilage morphology 0.384989980314018 0.670162754395466 0.895930717106932 0.333333333333333 3.1 3 1 abnormal lymph node B cell domain morphology 0.384989980314018 0.670162754395466 0.895930717106932 0.333333333333333 3.1 3 1 altered righting response 0.384989980314018 0.670162754395466 0.895930717106932 0.333333333333333 3.1 3 1 joint inflammation 0.384989980314018 0.670162754395466 0.895930717106932 0.333333333333333 3.1 3 1 arthritis 0.384989980314018 0.670162754395466 0.895930717106932 0.333333333333333 3.1 3 1 decreased aggression towards males 0.384989980314018 0.670162754395466 0.895930717106932 0.333333333333333 3.1 3 1 abnormal rostral migratory stream morphology 0.384989980314018 0.670162754395466 0.895930717106932 0.333333333333333 3.1 3 1 abnormal zygomatic bone morphology 0.384989980314018 0.670162754395466 0.895930717106932 0.333333333333333 3.1 3 1 abnormal aorta wall morphology 0.384989980314018 0.670162754395466 0.895930717106932 0.333333333333333 3.1 3 1 abnormal branching involved in lung morphogenesis 0.384989980314018 0.670162754395466 0.895930717106932 0.333333333333333 3.1 3 1 abnormal skeleton development 0.129098142381273 0.386905577317371 0.895930717106932 0.333333333333333 3.1 3 1 abnormal epidermal layer morphology 0.15223385171644 0.426372047425988 0.895930717106932 0.333333333333333 3.1 3 1 abnormal food intake 0.15223385171644 0.426372047425988 0.895930717106932 0.333333333333333 3.1 3 1 abnormal aorta morphology 0.265646446965848 0.533430470893258 0.895930717106932 0.333333333333333 3.1 3 1 small lens 0.23963772385417 0.533430470893258 0.895930717106932 0.333333333333333 3.1 3 1 abnormal limb bone morphology 0.25210996926395 0.533430470893258 0.895930717106932 0.333333333333333 3.1 3 1 dilated heart atrium 0.265646446965848 0.533430470893258 0.895930717106932 0.333333333333333 3.1 3 1 decreased trabecular bone volume 0.23963772385417 0.533430470893258 0.895930717106932 0.333333333333333 3.1 3 1 blepharoptosis 0.358061590056777 0.640315028947687 0.895930717106932 0.333333333333333 3.1 3 1 eye inflammation 0.358061590056777 0.640315028947687 0.895930717106932 0.333333333333333 3.1 3 1 abnormal metacarpal bone morphology 0.358061590056777 0.640315028947687 0.895930717106932 0.333333333333333 3.1 3 1 abnormal eye anterior chamber morphology 0.358061590056777 0.640315028947687 0.895930717106932 0.333333333333333 3.1 3 1 abnormal sperm axoneme morphology 0.358061590056777 0.640315028947687 0.895930717106932 0.333333333333333 3.1 3 1 impaired leukocyte tethering or rolling 0.358061590056777 0.640315028947687 0.895930717106932 0.333333333333333 3.1 3 1 decreased IgM level 0.118457604932311 0.370412686699085 0.8866943179615 0.329896907216495 3.1 3 1 abnormal action potential 0.171192330442744 0.466049820102856 0.883131706862547 0.328571428571429 3.1 3 1 abnormal epidermis stratum corneum morphology 0.234712703547817 0.533430470893258 0.877646416757811 0.326530612244898 3.1 3 1 impaired righting response 0.137278634161661 0.408225466200993 0.877069017799418 0.326315789473684 3.1 3 1 abnormal sleep pattern 0.246362088159777 0.533430470893258 0.876453962387216 0.326086956521739 3.1 3 1 decreased anxiety-related response 0.107196124324188 0.346074444200413 0.874078748397007 0.32520325203252 3.1 3 1 abnormal female reproductive system morphology 0.272404149570595 0.535656381072612 0.873532449179259 0.325 3.1 3 1 impaired skeletal muscle contractility 0.287056846900667 0.54504886874125 0.871716373401339 0.324324324324324 3.1 3 1 abnormal oocyte morphology 0.303024052315819 0.552011959088686 0.86957981366261 0.323529411764706 3.1 3 1 decreased pancreatic beta cell number 0.303024052315819 0.552011959088686 0.86957981366261 0.323529411764706 3.1 3 1 abnormal object recognition memory 0.320533849378722 0.581566703376785 0.867029726232515 0.32258064516129 3.1 3 1 autoimmune response 0.320533849378722 0.581566703376785 0.867029726232515 0.32258064516129 3.1 3 1 abnormal retinal photoreceptor layer morphology 0.320533849378722 0.581566703376785 0.867029726232515 0.32258064516129 3.1 3 1 abnormal nervous system electrophysiology 0.179321124939841 0.466049820102856 0.86393319149597 0.321428571428571 3.1 3 1 abnormal retinal inner nuclear layer morphology 0.3398839531041 0.612653140106122 0.86393319149597 0.321428571428571 3.1 3 1 abnormal vertebrae morphology 0.14342019732399 0.418553278123071 0.863052525653466 0.321100917431193 3.1 3 1 abnormal digestive system physiology 0.263469147088695 0.533430470893258 0.860093488422655 0.32 3.1 3 1 increased circulating chloride level 0.263469147088695 0.533430470893258 0.860093488422655 0.32 3.1 3 1 abnormal inner ear vestibule morphology 0.36147428569623 0.645721569600986 0.860093488422655 0.32 3.1 3 1 abnormal cochlear outer hair cell morphology 0.36147428569623 0.645721569600986 0.860093488422655 0.32 3.1 3 1 abnormal T-helper 1 physiology 0.276756831933659 0.539523996422395 0.85780600574068 0.319148936170213 3.1 3 1 abnormal spatial learning 0.100002969829704 0.332785802610553 0.857455164838536 0.319018404907975 3.1 3 1 decreased blood urea nitrogen level 0.291062640822923 0.54504886874125 0.855206593602071 0.318181818181818 3.1 3 1 increased coping response 0.385861244950774 0.670740633693257 0.855206593602071 0.318181818181818 3.1 3 1 abnormal female reproductive system physiology 0.385861244950774 0.670740633693257 0.855206593602071 0.318181818181818 3.1 3 1 abnormal mesenteric lymph node morphology 0.385861244950774 0.670740633693257 0.855206593602071 0.318181818181818 3.1 3 1 abnormal sperm midpiece morphology 0.385861244950774 0.670740633693257 0.855206593602071 0.318181818181818 3.1 3 1 arrested B cell differentiation 0.306523294820113 0.557977823538259 0.852226779687082 0.317073170731707 3.1 3 1 lethality at weaning, incomplete penetrance 0.306523294820113 0.557977823538259 0.852226779687082 0.317073170731707 3.1 3 1 short vibrissae 0.413853594932703 0.697939537217017 0.848776468838146 0.315789473684211 3.1 3 1 stereotypic behavior 0.413853594932703 0.697939537217017 0.848776468838146 0.315789473684211 3.1 3 1 unresponsive to tactile stimuli 0.413853594932703 0.697939537217017 0.848776468838146 0.315789473684211 3.1 3 1 abnormal cochlear inner hair cell morphology 0.413853594932703 0.697939537217017 0.848776468838146 0.315789473684211 3.1 3 1 Leydig cell hypoplasia 0.413853594932703 0.697939537217017 0.848776468838146 0.315789473684211 3.1 3 1 decreased tumor growth/size 0.279532360157899 0.544721305047218 0.846156788378769 0.314814814814815 3.1 3 1 rib fusion 0.256730056560289 0.533430470893258 0.842442316085623 0.313432835820896 3.1 3 1 small heart 0.308310606396173 0.561026066869408 0.839935047287749 0.3125 3.1 3 1 abnormal crypts of Lieberkuhn morphology 0.361728329213283 0.645943445023719 0.839935047287749 0.3125 3.1 3 1 failure of tooth eruption 0.446694965026499 0.70455315625401 0.839935047287749 0.3125 3.1 3 1 decreased mast cell number 0.446694965026499 0.70455315625401 0.839935047287749 0.3125 3.1 3 1 reduced male mating frequency 0.446694965026499 0.70455315625401 0.839935047287749 0.3125 3.1 3 1 decreased cochlear coiling 0.446694965026499 0.70455315625401 0.839935047287749 0.3125 3.1 3 1 increased cochlear outer hair cell number 0.446694965026499 0.70455315625401 0.839935047287749 0.3125 3.1 3 1 abnormal Langerhans cell physiology 0.446694965026499 0.70455315625401 0.839935047287749 0.3125 3.1 3 1 obese 0.247338800575233 0.533430470893258 0.837753397814274 0.311688311688312 3.1 3 1 abnormal ovarian follicle morphology 0.324350349138902 0.585501809494207 0.836202002633136 0.311111111111111 3.1 3 1 lethality at weaning, complete penetrance 0.324350349138902 0.585501809494207 0.836202002633136 0.311111111111111 3.1 3 1 small seminiferous tubules 0.258291525922659 0.533430470893258 0.83539485784295 0.310810810810811 3.1 3 1 abnormal spermiogenesis 0.294658480179968 0.54504886874125 0.834142391789212 0.310344827586207 3.1 3 1 decreased retinal photoreceptor cell number 0.383974287088457 0.670162754395466 0.834142391789212 0.310344827586207 3.1 3 1 increased retinal apoptosis 0.383974287088457 0.670162754395466 0.834142391789212 0.310344827586207 3.1 3 1 abnormal learning/memory/conditioning 0.308997061218589 0.562069608615166 0.830772119499155 0.309090909090909 3.1 3 1 abnormal excitatory postsynaptic currents 0.270564406507232 0.533430470893258 0.827012969637168 0.307692307692308 3.1 3 1 abnormal locomotor activation 0.249353568598678 0.533430470893258 0.827012969637168 0.307692307692308 3.1 3 1 decreased IgA level 0.324333465959056 0.585501809494207 0.827012969637168 0.307692307692308 3.1 3 1 abnormal lens fiber morphology 0.360492228632776 0.644430052981697 0.827012969637168 0.307692307692308 3.1 3 1 abnormal nerve conduction 0.408813429633222 0.695833906839052 0.827012969637168 0.307692307692308 3.1 3 1 heart right ventricle hypertrophy 0.381004156176558 0.666958366283736 0.821269824014688 0.305555555555556 3.1 3 1 abnormal epidermis stratum granulosum morphology 0.381004156176558 0.666958366283736 0.821269824014688 0.305555555555556 3.1 3 1 abnormal cardiovascular development 0.436871453211334 0.70455315625401 0.818023698228068 0.304347826086957 3.1 3 1 abnormal crista ampullaris morphology 0.436871453211334 0.70455315625401 0.818023698228068 0.304347826086957 3.1 3 1 abnormal lens development 0.436871453211334 0.70455315625401 0.818023698228068 0.304347826086957 3.1 3 1 abnormal basicranium morphology 0.436871453211334 0.70455315625401 0.818023698228068 0.304347826086957 3.1 3 1 kinked tail 0.259902296096287 0.533430470893258 0.816878006773967 0.303921568627451 3.1 3 1 abnormal seminal vesicle morphology 0.339284745160479 0.611794710827613 0.815936903079527 0.303571428571429 3.1 3 1 abnormal ovarian folliculogenesis 0.403503060625211 0.695833906839052 0.814482470097211 0.303030303030303 3.1 3 1 abnormal middle ear ossicle morphology 0.403503060625211 0.695833906839052 0.814482470097211 0.303030303030303 3.1 3 1 impaired macrophage phagocytosis 0.37756139953209 0.661397169954981 0.812588324817915 0.302325581395349 3.1 3 1 abnormal estrous cycle 0.428352653516182 0.70455315625401 0.806337645396239 0.3 3.1 3 1 abnormal vascular regression 0.469041216786589 0.70455315625401 0.806337645396239 0.3 3.1 3 1 waved hair 0.469041216786589 0.70455315625401 0.806337645396239 0.3 3.1 3 1 abnormal dopamine level 0.469041216786589 0.70455315625401 0.806337645396239 0.3 3.1 3 1 abnormal Peyer's patch T cell area morphology 0.469041216786589 0.70455315625401 0.806337645396239 0.3 3.1 3 1 decreased paired-pulse facilitation 0.469041216786589 0.70455315625401 0.806337645396239 0.3 3.1 3 1 decreased skin tensile strength 0.469041216786589 0.70455315625401 0.806337645396239 0.3 3.1 3 1 abnormal thymocyte activation 0.469041216786589 0.70455315625401 0.806337645396239 0.3 3.1 3 1 abnormal incus morphology 0.469041216786589 0.70455315625401 0.806337645396239 0.3 3.1 3 1 abnormal response to tactile stimuli 0.469041216786589 0.70455315625401 0.806337645396239 0.3 3.1 3 1 increased brown adipose tissue amount 0.42075109471636 0.70455315625401 0.799073342284561 0.297297297297297 3.1 3 1 abnormal breathing pattern 0.42075109471636 0.70455315625401 0.799073342284561 0.297297297297297 3.1 3 1 increased thermal nociceptive threshold 0.32816656911772 0.5921758002759 0.797476792150126 0.296703296703297 3.1 3 1 abnormal gametogenesis 0.41383507253916 0.697939537217017 0.794120408344781 0.295454545454545 3.1 3 1 abnormal bone remodeling 0.445369314087458 0.70455315625401 0.790527103329646 0.294117647058824 3.1 3 1 abnormal nervous system development 0.445369314087458 0.70455315625401 0.790527103329646 0.294117647058824 3.1 3 1 decreased cytotoxic T cell cytolysis 0.445369314087458 0.70455315625401 0.790527103329646 0.294117647058824 3.1 3 1 abnormal urinary bladder morphology 0.506660243316155 0.751669911977178 0.790527103329646 0.294117647058824 3.1 3 1 distended urinary bladder 0.506660243316155 0.751669911977178 0.790527103329646 0.294117647058824 3.1 3 1 increased incidence of corneal inflammation 0.506660243316155 0.751669911977178 0.790527103329646 0.294117647058824 3.1 3 1 abnormal glutamate-mediated receptor currents 0.506660243316155 0.751669911977178 0.790527103329646 0.294117647058824 3.1 3 1 abnormal involuntary movement 0.506660243316155 0.751669911977178 0.790527103329646 0.294117647058824 3.1 3 1 increased regulatory T cell number 0.506660243316155 0.751669911977178 0.790527103329646 0.294117647058824 3.1 3 1 increased trabecular bone mass 0.506660243316155 0.751669911977178 0.790527103329646 0.294117647058824 3.1 3 1 abnormal electroretinogram waveform feature 0.506660243316155 0.751669911977178 0.790527103329646 0.294117647058824 3.1 3 1 abnormal cardiovascular system morphology 0.428064803947691 0.70455315625401 0.783939377468565 0.291666666666667 3.1 3 1 abnormal cardiac muscle contractility 0.487172690943231 0.728489371037745 0.783939377468565 0.291666666666667 3.1 3 1 abnormal salivary gland morphology 0.522672698760451 0.761210970823549 0.767940614663085 0.285714285714286 3.1 3 1 abnormal anxiety-related response 0.522672698760451 0.761210970823549 0.767940614663085 0.285714285714286 3.1 3 1 abnormal associative learning 0.522672698760451 0.761210970823549 0.767940614663085 0.285714285714286 3.1 3 1 dry skin 0.522672698760451 0.761210970823549 0.767940614663085 0.285714285714286 3.1 3 1 impaired fertilization 0.436628850655489 0.70455315625401 0.767940614663084 0.285714285714286 3.1 3 1 enhanced long term potentiation 0.453273035708811 0.70455315625401 0.767940614663084 0.285714285714286 3.1 3 1 abnormal jaw morphology 0.502487147613267 0.750262172681874 0.767940614663084 0.285714285714286 3.1 3 1 abnormal respiration 0.502487147613267 0.750262172681874 0.767940614663084 0.285714285714286 3.1 3 1 absent corpus callosum 0.502487147613267 0.750262172681874 0.767940614663084 0.285714285714286 3.1 3 1 straub tail 0.502487147613267 0.750262172681874 0.767940614663084 0.285714285714286 3.1 3 1 enhanced coordination 0.502487147613267 0.750262172681874 0.767940614663084 0.285714285714286 3.1 3 1 abnormal eye physiology 0.464559259499584 0.70455315625401 0.761541109540892 0.283333333333333 3.1 3 1 abnormal excitatory postsynaptic potential 0.466284423536069 0.70455315625401 0.753892920492418 0.280487804878049 3.1 3 1 abnormal nest building behavior 0.536055404094843 0.777610920218418 0.752581802369823 0.28 3.1 3 1 abnormal stomach mucosa morphology 0.536055404094843 0.777610920218418 0.752581802369823 0.28 3.1 3 1 abnormal inhibitory postsynaptic currents 0.485050609708741 0.727622211942236 0.751000748163164 0.279411764705882 3.1 3 1 reduced long term depression 0.527586401604436 0.767917597420148 0.746608930922443 0.277777777777778 3.1 3 1 abnormal radius morphology 0.563813571492839 0.810217365157965 0.746608930922443 0.277777777777778 3.1 3 1 absent spleen 0.563813571492839 0.810217365157965 0.746608930922443 0.277777777777778 3.1 3 1 abnormal retinal rod cell morphology 0.563813571492839 0.810217365157965 0.746608930922443 0.277777777777778 3.1 3 1 abnormal thyroid cartilage morphology 0.563813571492839 0.810217365157965 0.746608930922443 0.277777777777778 3.1 3 1 abnormal body wall morphology 0.563813571492839 0.810217365157965 0.746608930922443 0.277777777777778 3.1 3 1 decreased heart rate variability 0.563813571492839 0.810217365157965 0.746608930922443 0.277777777777778 3.1 3 1 abnormal macrophage chemotaxis 0.563813571492839 0.810217365157965 0.746608930922443 0.277777777777778 3.1 3 1 increased effector memory CD8-positive, alpha-beta T cell number 0.563813571492839 0.810217365157965 0.746608930922443 0.277777777777778 3.1 3 1 decreased fluid intake 0.563813571492839 0.810217365157965 0.746608930922443 0.277777777777778 3.1 3 1 decreased monocyte cell number 0.505452254107331 0.751669911977178 0.744311672673451 0.276923076923077 3.1 3 1 abnormal CD8-positive, alpha-beta T cell physiology 0.54763490400367 0.792461793897109 0.741459903812633 0.275862068965517 3.1 3 1 enlarged epididymis 0.54763490400367 0.792461793897109 0.741459903812633 0.275862068965517 3.1 3 1 perinatal lethality 0.538211233052052 0.779278487902782 0.739142841613219 0.275 3.1 3 1 abnormal CNS synaptic transmission 0.524292814728421 0.763347015883493 0.73303422308749 0.272727272727273 3.1 3 1 abnormal retinal outer plexiform layer morphology 0.57397699393908 0.824346288928095 0.73303422308749 0.272727272727273 3.1 3 1 abnormal occipital bone morphology 0.57397699393908 0.824346288928095 0.73303422308749 0.272727272727273 3.1 3 1 dextrocardia 0.557897967707801 0.803806078582771 0.73303422308749 0.272727272727273 3.1 3 1 abnormal locomotor coordination 0.557897967707801 0.803806078582771 0.73303422308749 0.272727272727273 3.1 3 1 diarrhea 0.557897967707801 0.803806078582771 0.73303422308749 0.272727272727273 3.1 3 1 abnormal lymph node morphology 0.556819469383985 0.802949814546472 0.727943707649382 0.270833333333333 3.1 3 1 no spontaneous movement 0.582934026264914 0.825380223239599 0.723636348432522 0.269230769230769 3.1 3 1 abnormal synaptic transmission 0.591010267817302 0.825380223239599 0.716744573685546 0.266666666666667 3.1 3 1 overexpanded pulmonary alveoli 0.598408283011124 0.825380223239599 0.711474392996681 0.264705882352941 3.1 3 1 impaired synaptic plasticity 0.598408283011124 0.825380223239599 0.711474392996681 0.264705882352941 3.1 3 1 abnormal long term depression 0.617370705978602 0.830786925140261 0.707313724031788 0.263157894736842 3.1 3 1 maternal imprinting 0.617370705978602 0.830786925140261 0.707313724031788 0.263157894736842 3.1 3 1 decreased fertilization frequency 0.617370705978602 0.830786925140261 0.707313724031788 0.263157894736842 3.1 3 1 abnormal innervation pattern to muscle 0.622367184784166 0.837057784347452 0.701163169909773 0.260869565217391 3.1 3 1 blistering 0.622367184784166 0.837057784347452 0.701163169909773 0.260869565217391 3.1 3 1 abnormal T cell proliferation 0.632245023191019 0.850113240641978 0.693623780986012 0.258064516129032 3.1 3 1 impaired behavioral response to xenobiotic 0.637017996327659 0.856299522218347 0.691146553196776 0.257142857142857 3.1 3 1 abnormal intestinal mucosa morphology 0.646162771208418 0.868123085812012 0.68757473638439 0.255813953488372 3.1 3 1 abnormal axon guidance 0.646162771208418 0.868123085812012 0.68757473638439 0.255813953488372 3.1 3 1 abnormal cued conditioning behavior 0.654780102714445 0.879463015929904 0.68512348955236 0.254901960784314 3.1 3 1 abnormal contextual conditioning behavior 0.65890337373018 0.884762289961578 0.684165274881657 0.254545454545455 3.1 3 1 abnormal osteoblast morphology 0.667432016064478 0.893127919183228 0.671948037830199 0.25 3.1 3 1 abnormal basioccipital bone morphology 0.666813869042606 0.893127919183228 0.671948037830199 0.25 3.1 3 1 abnormal fibula morphology 0.666813869042606 0.893127919183228 0.671948037830199 0.25 3.1 3 1 abnormal lens epithelium morphology 0.666813869042606 0.893127919183228 0.671948037830199 0.25 3.1 3 1 abnormal postnatal subventricular zone morphology 0.666813869042606 0.893127919183228 0.671948037830199 0.25 3.1 3 1 kidney atrophy 0.666813869042606 0.893127919183228 0.671948037830199 0.25 3.1 3 1 nuclear cataracts 0.666813869042606 0.893127919183228 0.671948037830199 0.25 3.1 3 1 rib bifurcation 0.668971955120786 0.893939155714723 0.671948037830199 0.25 3.1 3 1 myoclonus 0.668971955120786 0.893939155714723 0.671948037830199 0.25 3.1 3 1 increased circulating luteinizing hormone level 0.668971955120786 0.893939155714723 0.671948037830199 0.25 3.1 3 1 reduced long term potentiation 0.725954769340497 0.925820296710836 0.671948037830199 0.25 3.1 3 1 increased incidence of induced tumors 0.711857984755779 0.915711991835971 0.639950512219237 0.238095238095238 3.1 3 1 increased vasoconstriction 0.711857984755779 0.915711991835971 0.639950512219237 0.238095238095238 3.1 3 1 abnormal stapes morphology 0.711857984755779 0.915711991835971 0.639950512219237 0.238095238095238 3.1 3 1 abnormal optic nerve morphology 0.738846947983567 0.94033347818323 0.639950512219237 0.238095238095238 3.1 3 1 abnormal retinal photoreceptor morphology 0.74077398688419 0.942303908143402 0.632421682663717 0.235294117647059 3.1 3 1 decreased regulatory T cell number 0.74077398688419 0.942303908143402 0.632421682663717 0.235294117647059 3.1 3 1 arrested T cell differentiation 0.743056699348713 0.944724528305609 0.627151501974852 0.233333333333333 3.1 3 1 abnormal pain threshold 0.743056699348713 0.944724528305609 0.627151501974852 0.233333333333333 3.1 3 1 abnormal long bone epiphysis morphology 0.752411217348926 0.950786336375643 0.610861852572908 0.227272727272727 3.1 3 1 increased activated T cell number 0.752411217348926 0.950786336375643 0.610861852572908 0.227272727272727 3.1 3 1 decreased airway responsiveness 0.752411217348926 0.950786336375643 0.610861852572908 0.227272727272727 3.1 3 1 abnormal body temperature homeostasis 0.775376771561374 0.977881031585774 0.60692080836276 0.225806451612903 3.1 3 1 abnormal brain commissure morphology 0.780819031283785 0.98418410961156 0.597287144737955 0.222222222222222 3.1 3 1 abnormal systemic arterial blood pressure 0.799522590614904 0.98905007601245 0.597287144737955 0.222222222222222 3.1 3 1 abnormal regulatory T cell physiology 0.788534559728026 0.9872501136065 0.584302641591477 0.217391304347826 3.1 3 1 increased grooming behavior 0.847633060410783 1 0.565850979225431 0.210526315789474 3.1 3 1 abnormal male reproductive system morphology 0.862371199011323 1 0.562561147950864 0.209302325581395 3.1 3 1 absent long term depression 0.838386322111766 1 0.556094927859475 0.206896551724138 3.1 3 1 thin skin 0.854118618930119 1 0.553368972330752 0.205882352941176 3.1 3 1 abnormal vertebrae development 0.848274720904056 1 0.537558430264159 0.2 3.1 3 1 increased susceptibility to pharmacologically induced seizures 0.961968501099197 1 0.531958863282241 0.197916666666667 3.1 3 1 decreased susceptibility to pharmacologically induced seizures 0.893282110189904 1 0.497739287281629 0.185185185185185 3.1 3 1 abnormal spleen marginal zone morphology 0.939053740154177 1 0.447965358553466 0.166666666666667 3.1 3 1 abnormal geniculate ganglion morphology 0.0005388742952309 0.00485670220792342 1.30728422770863 1 30.3 30 3 decreased transitional stage T1 B cell number 0.0005388742952309 0.00485670220792342 1.30728422770863 1 30.3 30 3 increased cardiac muscle glycogen level 0.0005388742952309 0.00485670220792342 1.30728422770863 1 30.3 30 3 abnormal ovary development 0.00124371967315762 0.00966797714681117 1.30728422770863 1 30.3 30 3 abnormal extraembryonic tissue physiology 0.00124371967315762 0.00966797714681117 1.30728422770863 1 30.3 30 3 abnormal hepatic vein morphology 0.00124371967315762 0.00966797714681117 1.30728422770863 1 30.3 30 3 abnormal visual evoked potential 0.00124371967315762 0.00966797714681117 1.30728422770863 1 30.3 30 3 abnormal anterior commissure pars posterior morphology 0.00124371967315762 0.00966797714681117 1.30728422770863 1 30.3 30 3 increased aorta wall thickness 0.00124371967315762 0.00966797714681117 1.30728422770863 1 30.3 30 3 impaired neuron differentiation 0.00124371967315762 0.00966797714681117 1.30728422770863 1 30.3 30 3 increased cardiac stroke volume 0.00124371967315762 0.00966797714681117 1.30728422770863 1 30.3 30 3 increased brain apoptosis 0.00124371967315762 0.00966797714681117 1.30728422770863 1 30.3 30 3 broad head 0.00287038923206906 0.0189594363437208 1.30728422770863 1 30.3 30 3 mammary gland hyperplasia 0.00287038923206906 0.0189594363437208 1.30728422770863 1 30.3 30 3 abnormal circulating alanine transaminase level 0.00287038923206906 0.0189594363437208 1.30728422770863 1 30.3 30 3 skeletal muscle interstitial fibrosis 0.00287038923206906 0.0189594363437208 1.30728422770863 1 30.3 30 3 decreased brain cholesterol level 0.00287038923206906 0.0189594363437208 1.30728422770863 1 30.3 30 3 heart block 0.00287038923206906 0.0189594363437208 1.30728422770863 1 30.3 30 3 abnormal outer hair cell kinocilium morphology 0.00287038923206906 0.0189594363437208 1.30728422770863 1 30.3 30 3 pale placenta 4.38209566672293e-05 0.000559700050674403 1.30728422770863 1 30.3 30 3 osteosclerosis 0.000233472472184073 0.00238506272919048 1.30728422770863 1 30.3 30 3 abnormal inferior vena cava valve morphology 0.000233472472184073 0.00238506272919048 1.30728422770863 1 30.3 30 3 lethality during fetal growth through weaning, complete penetrance 0.000233472472184073 0.00238506272919048 1.30728422770863 1 30.3 30 3 decreased circulating lactate level 0.000233472472184073 0.00238506272919048 1.30728422770863 1 30.3 30 3 large anterior fontanelle 0.00662433571295628 0.0362154617274258 1.30728422770863 1 30.3 30 3 thin tail 0.00662433571295628 0.0362154617274258 1.30728422770863 1 30.3 30 3 absent ectoplacental cone 0.00662433571295628 0.0362154617274258 1.30728422770863 1 30.3 30 3 abnormal hippocampal fimbria morphology 0.00662433571295628 0.0362154617274258 1.30728422770863 1 30.3 30 3 decreased posterior semicircular canal size 0.00662433571295628 0.0362154617274258 1.30728422770863 1 30.3 30 3 calcified joint 0.00662433571295628 0.0362154617274258 1.30728422770863 1 30.3 30 3 abnormal metopic suture morphology 0.00662433571295628 0.0362154617274258 1.30728422770863 1 30.3 30 3 abnormal ST segment 0.00662433571295628 0.0362154617274258 1.30728422770863 1 30.3 30 3 abnormal extensor digitorum longus morphology 0.00662433571295628 0.0362154617274258 1.30728422770863 1 30.3 30 3 vestibular saccular degeneration 0.00662433571295628 0.0362154617274258 1.30728422770863 1 30.3 30 3 abnormal right lung morphology 0.00662433571295628 0.0362154617274258 1.30728422770863 1 30.3 30 3 delayed chorioallantoic fusion 0.00662433571295628 0.0362154617274258 1.30728422770863 1 30.3 30 3 visceral vascular congestion 0.00662433571295628 0.0362154617274258 1.30728422770863 1 30.3 30 3 myocardium hypoplasia 0.00662433571295628 0.0362154617274258 1.30728422770863 1 30.3 30 3 abnormal intestinal enteroendocrine cell morphology 0.00662433571295628 0.0362154617274258 1.30728422770863 1 30.3 30 3 delayed limb development 0.00662433571295628 0.0362154617274258 1.30728422770863 1 30.3 30 3 additional anastomosis between intracranial vertebral arteries 0.00662433571295628 0.0362154617274258 1.30728422770863 1 30.3 30 3 abnormal Wolffian duct connection 0.00662433571295628 0.0362154617274258 1.30728422770863 1 30.3 30 3 decreased retinal apoptosis 0.00662433571295628 0.0362154617274258 1.30728422770863 1 30.3 30 3 small hair follicles 0.0152871712510385 0.0674832981135019 1.30728422770863 1 30.3 30 3 dissociated hepatocytes 0.0152871712510385 0.0674832981135019 1.30728422770863 1 30.3 30 3 abnormal pineal gland morphology 0.0152871712510385 0.0674832981135019 1.30728422770863 1 30.3 30 3 kinked vibrissae 0.0152871712510385 0.0674832981135019 1.30728422770863 1 30.3 30 3 corneal scarring 0.0152871712510385 0.0674832981135019 1.30728422770863 1 30.3 30 3 enhanced NMDA-mediated synaptic currents 0.0152871712510385 0.0674832981135019 1.30728422770863 1 30.3 30 3 epidermal cyst 0.0152871712510385 0.0674832981135019 1.30728422770863 1 30.3 30 3 abnormal response to vitamins 0.0152871712510385 0.0674832981135019 1.30728422770863 1 30.3 30 3 increased heart right ventricle weight 0.0152871712510385 0.0674832981135019 1.30728422770863 1 30.3 30 3 abnormal Descemet membrane 0.0152871712510385 0.0674832981135019 1.30728422770863 1 30.3 30 3 scapular bone foramen 0.0152871712510385 0.0674832981135019 1.30728422770863 1 30.3 30 3 erythroblastosis 0.0152871712510385 0.0674832981135019 1.30728422770863 1 30.3 30 3 abnormal olfactory cortex morphology 0.0152871712510385 0.0674832981135019 1.30728422770863 1 30.3 30 3 abnormal mesangial cell morphology 0.0152871712510385 0.0674832981135019 1.30728422770863 1 30.3 30 3 corneal deposits 0.0152871712510385 0.0674832981135019 1.30728422770863 1 30.3 30 3 absent optic chiasm 0.0152871712510385 0.0674832981135019 1.30728422770863 1 30.3 30 3 abnormal mismatch repair 0.0152871712510385 0.0674832981135019 1.30728422770863 1 30.3 30 3 abnormal cranium size 0.0152871712510385 0.0674832981135019 1.30728422770863 1 30.3 30 3 decreased DN3 thymocyte number 0.0152871712510385 0.0674832981135019 1.30728422770863 1 30.3 30 3 increased T follicular helper cell number 0.0152871712510385 0.0674832981135019 1.30728422770863 1 30.3 30 3 aorta hypoplasia 0.0152871712510385 0.0674832981135019 1.30728422770863 1 30.3 30 3 enlarged aortic valve 0.0152871712510385 0.0674832981135019 1.30728422770863 1 30.3 30 3 trachea stenosis 0.0152871712510385 0.0674832981135019 1.30728422770863 1 30.3 30 3 abnormal lung alveolus development 0.0152871712510385 0.0674832981135019 1.30728422770863 1 30.3 30 3 decreased pre-pro B cell number 0.0152871712510385 0.0674832981135019 1.30728422770863 1 30.3 30 3 cerebral edema 0.0152871712510385 0.0674832981135019 1.30728422770863 1 30.3 30 3 decreased small intestinal villus height 0.0152871712510385 0.0674832981135019 1.30728422770863 1 30.3 30 3 increased muscle cell glucose uptake 6.69974189036437e-07 1.4158306917503e-05 1.24503259781774 0.952380952380952 30.3 30 3 abnormal mitral valve morphology 7.10914676834066e-06 0.000111924067001566 1.23465732616926 0.944444444444444 30.3 30 3 absent inner cell mass 7.10914676834066e-06 0.000111924067001566 1.23465732616926 0.944444444444444 30.3 30 3 primary atelectasis 7.10914676834066e-06 0.000111924067001566 1.23465732616926 0.944444444444444 30.3 30 3 abnormal embryonic hematopoiesis 2.10777625251806e-09 7.28207420574816e-08 1.22557896347684 0.9375 30.3 30 3 abnormal hair follicle orientation 3.38507544069051e-05 0.000450287441642655 1.22557896347684 0.9375 30.3 30 3 disorganized yolk sac vascular plexus 3.38507544069051e-05 0.000450287441642655 1.22557896347684 0.9375 30.3 30 3 dystonia 3.38507544069051e-05 0.000450287441642655 1.22557896347684 0.9375 30.3 30 3 abnormal object recognition memory 4.57161203144894e-09 1.49630064845122e-07 1.22294330979194 0.935483870967742 30.3 30 3 delayed intramembranous bone ossification 7.34821036104535e-05 0.000872490371031041 1.22013194586139 0.933333333333333 30.3 30 3 abnormal glial cell morphology 7.34821036104535e-05 0.000872490371031041 1.22013194586139 0.933333333333333 30.3 30 3 abnormal pericyte morphology 7.34821036104535e-05 0.000872490371031041 1.22013194586139 0.933333333333333 30.3 30 3 decreased trophoblast giant cell number 2.13693496179537e-08 6.00635674289941e-07 1.21712669476321 0.931034482758621 30.3 30 3 midline facial cleft 0.000158864594565769 0.0016960329570058 1.2139067828723 0.928571428571429 30.3 30 3 absent olfactory bulb 0.000158864594565769 0.0016960329570058 1.2139067828723 0.928571428571429 30.3 30 3 spina bifida occulta 0.000158864594565769 0.0016960329570058 1.2139067828723 0.928571428571429 30.3 30 3 abnormal cell differentiation 3.1994799008577e-11 1.57598143631357e-09 1.21162928421776 0.926829268292683 30.3 30 3 absent hypoglossal nerve 0.000341868588691581 0.00335462767009983 1.20672390250027 0.923076923076923 30.3 30 3 interstitial pneumonia 0.00073177299159847 0.00614961255608511 1.19834387539958 0.916666666666667 30.3 30 3 abnormal respiratory function 0.00073177299159847 0.00614961255608511 1.19834387539958 0.916666666666667 30.3 30 3 abnormal corticospinal tract morphology 0.00073177299159847 0.00614961255608511 1.19834387539958 0.916666666666667 30.3 30 3 decreased red blood cell distribution width 0.00073177299159847 0.00614961255608511 1.19834387539958 0.916666666666667 30.3 30 3 increased adenoma incidence 4.33482092612856e-06 7.36031880801693e-05 1.18844020700785 0.909090909090909 30.3 30 3 decreased atrioventricular cushion size 0.00155669426490981 0.0115936436645603 1.18844020700785 0.909090909090909 30.3 30 3 abnormal proximal-distal axis patterning 0.00155669426490981 0.0115936436645603 1.18844020700785 0.909090909090909 30.3 30 3 abnormal spinal cord ventral horn morphology 0.00155669426490981 0.0115936436645603 1.18844020700785 0.909090909090909 30.3 30 3 abnormal palate development 0.00155669426490981 0.0115936436645603 1.18844020700785 0.909090909090909 30.3 30 3 palatal shelf hypoplasia 0.00155669426490981 0.0115936436645603 1.18844020700785 0.909090909090909 30.3 30 3 aorta dilation 0.00155669426490981 0.0115936436645603 1.18844020700785 0.909090909090909 30.3 30 3 thin hypoglossal nerve 0.00155669426490981 0.0115936436645603 1.18844020700785 0.909090909090909 30.3 30 3 decreased paired-pulse facilitation 1.91508941786572e-05 0.000269902828721869 1.17655580493777 0.9 30.3 30 3 absent ductus venosus valve 1.91508941786572e-05 0.000269902828721869 1.17655580493777 0.9 30.3 30 3 alcohol preference 0.00328749070265234 0.0205726619442709 1.17655580493777 0.9 30.3 30 3 ketoaciduria 0.00328749070265234 0.0205726619442709 1.17655580493777 0.9 30.3 30 3 abnormal tibialis anterior morphology 0.00328749070265234 0.0205726619442709 1.17655580493777 0.9 30.3 30 3 abnormal pillar cell morphology 0.00328749070265234 0.0205726619442709 1.17655580493777 0.9 30.3 30 3 increased heart rate variability 0.00328749070265234 0.0205726619442709 1.17655580493777 0.9 30.3 30 3 abnormal plasma membrane morphology 0.00328749070265234 0.0205726619442709 1.17655580493777 0.9 30.3 30 3 abnormal embryonic erythrocyte morphology 0.00328749070265234 0.0205726619442709 1.17655580493777 0.9 30.3 30 3 abnormal spinal cord dorsal column morphology 0.00328749070265234 0.0205726619442709 1.17655580493777 0.9 30.3 30 3 decreased transitional stage T2 B cell number 0.00328749070265234 0.0205726619442709 1.17655580493777 0.9 30.3 30 3 abnormal hippocampus neuron morphology 0.00328749070265234 0.0205726619442709 1.17655580493777 0.9 30.3 30 3 increased circulating fructosamine level 0.00328749070265234 0.0205726619442709 1.17655580493777 0.9 30.3 30 3 aorta stenosis 0.00328749070265234 0.0205726619442709 1.17655580493777 0.9 30.3 30 3 increased fatty acid oxidation 0.00328749070265234 0.0205726619442709 1.17655580493777 0.9 30.3 30 3 abnormal brainstem morphology 5.39816482171953e-07 1.1778890345638e-05 1.16721806045413 0.892857142857143 30.3 30 3 small thoracic cage 8.29673205664731e-05 0.000964398177145335 1.16203042462989 0.888888888888889 30.3 30 3 increased adipocyte glucose uptake 8.29673205664731e-05 0.000964398177145335 1.16203042462989 0.888888888888889 30.3 30 3 abnormal ion homeostasis 0.00688248269657137 0.0367678767706968 1.16203042462989 0.888888888888889 30.3 30 3 abnormal posterior semicircular canal morphology 0.00688248269657137 0.0367678767706968 1.16203042462989 0.888888888888889 30.3 30 3 polycythemia 0.00688248269657137 0.0367678767706968 1.16203042462989 0.888888888888889 30.3 30 3 premature bone ossification 0.00688248269657137 0.0367678767706968 1.16203042462989 0.888888888888889 30.3 30 3 abnormal posterior eye segment morphology 0.00688248269657137 0.0367678767706968 1.16203042462989 0.888888888888889 30.3 30 3 abnormal inguinal fat pad morphology 0.00688248269657137 0.0367678767706968 1.16203042462989 0.888888888888889 30.3 30 3 abnormal retinal development 0.00688248269657137 0.0367678767706968 1.16203042462989 0.888888888888889 30.3 30 3 eye opacity 0.00688248269657137 0.0367678767706968 1.16203042462989 0.888888888888889 30.3 30 3 axonal spheroids 0.00688248269657137 0.0367678767706968 1.16203042462989 0.888888888888889 30.3 30 3 abnormal ventricle myocardium morphology 0.00688248269657137 0.0367678767706968 1.16203042462989 0.888888888888889 30.3 30 3 shortened ST segment 0.00688248269657137 0.0367678767706968 1.16203042462989 0.888888888888889 30.3 30 3 iris coloboma 0.00688248269657137 0.0367678767706968 1.16203042462989 0.888888888888889 30.3 30 3 abnormal ductus venosus valve topology 0.00688248269657137 0.0367678767706968 1.16203042462989 0.888888888888889 30.3 30 3 abnormal infrahyoid muscle connection 0.00688248269657137 0.0367678767706968 1.16203042462989 0.888888888888889 30.3 30 3 cerebellum atrophy 0.00688248269657137 0.0367678767706968 1.16203042462989 0.888888888888889 30.3 30 3 abnormal Schwann cell morphology 2.30170602777851e-06 4.20992187066106e-05 1.1564437398961 0.884615384615385 30.3 30 3 enlarged liver sinusoidal spaces 6.67180579532936e-08 1.70216583752634e-06 1.15348608327232 0.882352941176471 30.3 30 3 increased brain size 0.000171197666864361 0.00181600936599188 1.15348608327232 0.882352941176471 30.3 30 3 enhanced behavioral response to cocaine 0.000171197666864361 0.00181600936599188 1.15348608327232 0.882352941176471 30.3 30 3 increased fibroblast apoptosis 2.77910532724259e-07 6.49110281832484e-06 1.14387369924505 0.875 30.3 30 3 ocular hypertelorism 9.63808496256582e-06 0.00014618741673404 1.14387369924505 0.875 30.3 30 3 abnormal epicardium morphology 0.000350901548035294 0.00339255618502877 1.14387369924505 0.875 30.3 30 3 increased cochlear outer hair cell number 0.000350901548035294 0.00339255618502877 1.14387369924505 0.875 30.3 30 3 embryonic lethality between somite formation and embryo turning, incomplete penetrance 0.000350901548035294 0.00339255618502877 1.14387369924505 0.875 30.3 30 3 decreased fibroblast apoptosis 0.000350901548035294 0.00339255618502877 1.14387369924505 0.875 30.3 30 3 abnormal exoccipital bone morphology 0.0142570761444491 0.0657968031712751 1.14387369924505 0.875 30.3 30 3 abnormal bone marrow development 0.0142570761444491 0.0657968031712751 1.14387369924505 0.875 30.3 30 3 failure of vascular branching 0.0142570761444491 0.0657968031712751 1.14387369924505 0.875 30.3 30 3 schistocytosis 0.0142570761444491 0.0657968031712751 1.14387369924505 0.875 30.3 30 3 absent eyelids 0.0142570761444491 0.0657968031712751 1.14387369924505 0.875 30.3 30 3 poor grooming 0.0142570761444491 0.0657968031712751 1.14387369924505 0.875 30.3 30 3 decreased aerobic running capacity 0.0142570761444491 0.0657968031712751 1.14387369924505 0.875 30.3 30 3 altered response to CNS ischemic injury 0.0142570761444491 0.0657968031712751 1.14387369924505 0.875 30.3 30 3 early eyelid opening 0.0142570761444491 0.0657968031712751 1.14387369924505 0.875 30.3 30 3 abnormal neuron apoptosis 0.0142570761444491 0.0657968031712751 1.14387369924505 0.875 30.3 30 3 colon polyps 0.0142570761444491 0.0657968031712751 1.14387369924505 0.875 30.3 30 3 liver failure 0.0142570761444491 0.0657968031712751 1.14387369924505 0.875 30.3 30 3 increased cardiac output 0.0142570761444491 0.0657968031712751 1.14387369924505 0.875 30.3 30 3 abnormal eyelid aperture 0.0142570761444491 0.0657968031712751 1.14387369924505 0.875 30.3 30 3 elevated level of mitotic sister chromatid exchange 0.0142570761444491 0.0657968031712751 1.14387369924505 0.875 30.3 30 3 lymph node inflammation 0.0142570761444491 0.0657968031712751 1.14387369924505 0.875 30.3 30 3 tau protein deposits 0.0142570761444491 0.0657968031712751 1.14387369924505 0.875 30.3 30 3 abnormal vestibular labyrinth morphology 0.0142570761444491 0.0657968031712751 1.14387369924505 0.875 30.3 30 3 accumulation of giant lysosomes in kidney/renal tubule cells 0.0142570761444491 0.0657968031712751 1.14387369924505 0.875 30.3 30 3 abnormal choroid pigmentation 0.0142570761444491 0.0657968031712751 1.14387369924505 0.875 30.3 30 3 abnormal somite size 0.0142570761444491 0.0657968031712751 1.14387369924505 0.875 30.3 30 3 craniofacial phenotype 0.0142570761444491 0.0657968031712751 1.14387369924505 0.875 30.3 30 3 abnormal mitotic spindle assembly checkpoint 0.0142570761444491 0.0657968031712751 1.14387369924505 0.875 30.3 30 3 abnormal cerebellum deep nucleus morphology 0.0142570761444491 0.0657968031712751 1.14387369924505 0.875 30.3 30 3 pulmonary artery hypoplasia 0.0142570761444491 0.0657968031712751 1.14387369924505 0.875 30.3 30 3 myocardial trabeculae hypoplasia 0.0142570761444491 0.0657968031712751 1.14387369924505 0.875 30.3 30 3 delayed suture closure 0.0142570761444491 0.0657968031712751 1.14387369924505 0.875 30.3 30 3 decreased alveolar lamellar body number 0.0142570761444491 0.0657968031712751 1.14387369924505 0.875 30.3 30 3 abnormal foramen magnum morphology 0.0142570761444491 0.0657968031712751 1.14387369924505 0.875 30.3 30 3 abnormal bronchus epithelium morphology 0.0142570761444491 0.0657968031712751 1.14387369924505 0.875 30.3 30 3 lethality during fetal growth through weaning, incomplete penetrance 0.0142570761444491 0.0657968031712751 1.14387369924505 0.875 30.3 30 3 increased cornea thickness 0.0142570761444491 0.0657968031712751 1.14387369924505 0.875 30.3 30 3 absent hypoglossal canal 0.0142570761444491 0.0657968031712751 1.14387369924505 0.875 30.3 30 3 impaired limb coordination 3.10036606426839e-11 1.54243211697353e-09 1.1378214574501 0.87037037037037 30.3 30 3 abnormal cell adhesion 3.10036606426839e-11 1.54243211697353e-09 1.1378214574501 0.87037037037037 30.3 30 3 abnormal cell death 1.01679089167532e-09 3.83222324703387e-08 1.13676889365968 0.869565217391304 30.3 30 3 abnormal prostate gland morphology 0.000713850785775323 0.00608117749868532 1.13297966401415 0.866666666666667 30.3 30 3 audiogenic seizures 0.000713850785775323 0.00608117749868532 1.13297966401415 0.866666666666667 30.3 30 3 abnormal lymph node B cell domain morphology 0.000713850785775323 0.00608117749868532 1.13297966401415 0.866666666666667 30.3 30 3 abnormal ear development 0.000713850785775323 0.00608117749868532 1.13297966401415 0.866666666666667 30.3 30 3 heterochrony 0.000713850785775323 0.00608117749868532 1.13297966401415 0.866666666666667 30.3 30 3 abnormal limb posture 3.9510594277709e-05 0.000513225082327943 1.12901819665745 0.863636363636364 30.3 30 3 abnormal occipital bone morphology 3.9510594277709e-05 0.000513225082327943 1.12901819665745 0.863636363636364 30.3 30 3 abnormal axon morphology 2.97584844165467e-20 4.22995599920914e-18 1.12571697386021 0.861111111111111 30.3 30 3 abnormal lysosome morphology 1.36190053094877e-07 3.3708732047115e-06 1.12571697386021 0.861111111111111 30.3 30 3 abnormal interparietal bone morphology 0.00143989255344644 0.0108702055438483 1.12052933803597 0.857142857142857 30.3 30 3 increased lactate dehydrogenase level 0.00143989255344644 0.0108702055438483 1.12052933803597 0.857142857142857 30.3 30 3 increased hemangioma incidence 0.00143989255344644 0.0108702055438483 1.12052933803597 0.857142857142857 30.3 30 3 amyloid beta deposits 0.00143989255344644 0.0108702055438483 1.12052933803597 0.857142857142857 30.3 30 3 skeletal muscle necrosis 0.00143989255344644 0.0108702055438483 1.12052933803597 0.857142857142857 30.3 30 3 split sternum 0.00143989255344644 0.0108702055438483 1.12052933803597 0.857142857142857 30.3 30 3 lysosomal protein accumulation 0.00143989255344644 0.0108702055438483 1.12052933803597 0.857142857142857 30.3 30 3 abnormal viscerocranium morphology 0.00143989255344644 0.0108702055438483 1.12052933803597 0.857142857142857 30.3 30 3 testis degeneration 0.00143989255344644 0.0108702055438483 1.12052933803597 0.857142857142857 30.3 30 3 abnormal oculomotor nerve morphology 0.0291480145982796 0.114815021873667 1.12052933803597 0.857142857142857 30.3 30 3 decreased Schwann cell number 0.0291480145982796 0.114815021873667 1.12052933803597 0.857142857142857 30.3 30 3 skin photosensitivity 0.0291480145982796 0.114815021873667 1.12052933803597 0.857142857142857 30.3 30 3 abnormal axial mesoderm 0.0291480145982796 0.114815021873667 1.12052933803597 0.857142857142857 30.3 30 3 abnormal gastrulation movements 0.0291480145982796 0.114815021873667 1.12052933803597 0.857142857142857 30.3 30 3 abnormal melanocyte morphology 0.0291480145982796 0.114815021873667 1.12052933803597 0.857142857142857 30.3 30 3 decreased cardiomyocyte apoptosis 0.0291480145982796 0.114815021873667 1.12052933803597 0.857142857142857 30.3 30 3 aorta coarctation 0.0291480145982796 0.114815021873667 1.12052933803597 0.857142857142857 30.3 30 3 anuria 0.0291480145982796 0.114815021873667 1.12052933803597 0.857142857142857 30.3 30 3 increased cell nucleus count 0.0291480145982796 0.114815021873667 1.12052933803597 0.857142857142857 30.3 30 3 abnormal optic tract morphology 0.0291480145982796 0.114815021873667 1.12052933803597 0.857142857142857 30.3 30 3 abnormal organ of Corti supporting cell morphology 0.0291480145982796 0.114815021873667 1.12052933803597 0.857142857142857 30.3 30 3 absent deltoid tuberosity 0.0291480145982796 0.114815021873667 1.12052933803597 0.857142857142857 30.3 30 3 increased thyroid-stimulating hormone level 0.0291480145982796 0.114815021873667 1.12052933803597 0.857142857142857 30.3 30 3 decreased tidal volume 0.0291480145982796 0.114815021873667 1.12052933803597 0.857142857142857 30.3 30 3 heart hemorrhage 0.0291480145982796 0.114815021873667 1.12052933803597 0.857142857142857 30.3 30 3 postaxial polydactyly 0.0291480145982796 0.114815021873667 1.12052933803597 0.857142857142857 30.3 30 3 enhanced behavioral response to alcohol 0.0291480145982796 0.114815021873667 1.12052933803597 0.857142857142857 30.3 30 3 abnormal sperm annulus morphology 0.0291480145982796 0.114815021873667 1.12052933803597 0.857142857142857 30.3 30 3 abnormal cerebellum white matter morphology 0.0291480145982796 0.114815021873667 1.12052933803597 0.857142857142857 30.3 30 3 decreased DN2 thymocyte number 0.0291480145982796 0.114815021873667 1.12052933803597 0.857142857142857 30.3 30 3 increased oligodendrocyte number 0.0291480145982796 0.114815021873667 1.12052933803597 0.857142857142857 30.3 30 3 abnormal retina inner limiting membrane morphology 0.0291480145982796 0.114815021873667 1.12052933803597 0.857142857142857 30.3 30 3 embryonic lethality at implantation, incomplete penetrance 0.0291480145982796 0.114815021873667 1.12052933803597 0.857142857142857 30.3 30 3 dysmyelination 0.0291480145982796 0.114815021873667 1.12052933803597 0.857142857142857 30.3 30 3 ductus venosus stenosis 0.0291480145982796 0.114815021873667 1.12052933803597 0.857142857142857 30.3 30 3 absent connection between subcutaneous lymph vessels and lymph sac 0.0291480145982796 0.114815021873667 1.12052933803597 0.857142857142857 30.3 30 3 decreased collagen level 0.0291480145982796 0.114815021873667 1.12052933803597 0.857142857142857 30.3 30 3 gliosis 3.84418101773996e-12 2.22381401898329e-10 1.12052933803597 0.857142857142857 30.3 30 3 holoprosencephaly 2.71972462941794e-07 6.38237265629918e-06 1.12052933803597 0.857142857142857 30.3 30 3 increased red blood cell distribution width 2.71972462941794e-07 6.38237265629918e-06 1.12052933803597 0.857142857142857 30.3 30 3 abnormal embryonic/fetal subventricular zone morphology 7.92671554970817e-05 0.000925713846474135 1.12052933803597 0.857142857142857 30.3 30 3 decreased circulating total protein level 1.23059624867064e-10 5.51551021363642e-09 1.11713379458738 0.854545454545454 30.3 30 3 increased brain weight 9.11369379026952e-06 0.000139509620327972 1.11361249027032 0.851851851851852 30.3 30 3 decreased circulating fructosamine level 9.11369379026952e-06 0.000139509620327972 1.11361249027032 0.851851851851852 30.3 30 3 anencephaly 0.000157934887351739 0.0016960329570058 1.11119159355234 0.85 30.3 30 3 abnormal postnatal subventricular zone morphology 0.000157934887351739 0.0016960329570058 1.11119159355234 0.85 30.3 30 3 failure to gastrulate 7.79895884837888e-09 2.40992672488726e-07 1.10834967131819 0.847826086956522 30.3 30 3 liver hypoplasia 9.47233465773756e-10 3.59731793299575e-08 1.10616357729192 0.846153846153846 30.3 30 3 failure of heart looping 1.27457300948328e-07 3.17050036108966e-06 1.10616357729192 0.846153846153846 30.3 30 3 absent trabeculae carneae 0.00287624720758636 0.0189594363437208 1.10616357729192 0.846153846153846 30.3 30 3 abnormal grip strength 0.00287624720758636 0.0189594363437208 1.10616357729192 0.846153846153846 30.3 30 3 axonal dystrophy 0.00287624720758636 0.0189594363437208 1.10616357729192 0.846153846153846 30.3 30 3 increased cochlear inner hair cell number 0.00287624720758636 0.0189594363437208 1.10616357729192 0.846153846153846 30.3 30 3 abnormal neural tube closure 1.35982024813147e-14 1.12751762240901e-12 1.10252886674222 0.843373493975904 30.3 30 3 failure of chorioallantoic fusion 1.85824337050706e-09 6.51039490723425e-08 1.10222003512688 0.843137254901961 30.3 30 3 delayed sexual maturation 0.000312294400096358 0.00307048347920826 1.10087092859674 0.842105263157895 30.3 30 3 embryonic lethality between implantation and somite formation, incomplete penetrance 0.000312294400096358 0.00307048347920826 1.10087092859674 0.842105263157895 30.3 30 3 abnormal astrocyte morphology 3.00287694172046e-08 8.16355889893951e-07 1.09930719148226 0.840909090909091 30.3 30 3 abnormal trophoblast giant cell morphology 9.50884512176384e-07 1.93087773390919e-05 1.08940352309053 0.833333333333333 30.3 30 3 abnormal retinal blood vessel morphology 9.50884512176384e-07 1.93087773390919e-05 1.08940352309053 0.833333333333333 30.3 30 3 abnormal optic cup morphology 8.04324142836087e-06 0.000125833729893381 1.08940352309053 0.833333333333333 30.3 30 3 decreased cellular sensitivity to gamma-irradiation 0.0006123493983538 0.00536344763522915 1.08940352309053 0.833333333333333 30.3 30 3 abnormal eye anterior chamber morphology 0.0006123493983538 0.00536344763522915 1.08940352309053 0.833333333333333 30.3 30 3 abnormal aerobic respiration 0.0006123493983538 0.00536344763522915 1.08940352309053 0.833333333333333 30.3 30 3 abnormal hypoglossal nerve topology 0.0006123493983538 0.00536344763522915 1.08940352309053 0.833333333333333 30.3 30 3 abnormal supraoccipital bone morphology 0.00568130063146651 0.0323762550304077 1.08940352309053 0.833333333333333 30.3 30 3 abnormal enteric nervous system morphology 0.00568130063146651 0.0323762550304077 1.08940352309053 0.833333333333333 30.3 30 3 abnormal thymus involution 0.00568130063146651 0.0323762550304077 1.08940352309053 0.833333333333333 30.3 30 3 myocarditis 0.00568130063146651 0.0323762550304077 1.08940352309053 0.833333333333333 30.3 30 3 abnormal embryonic growth/weight/body size 0.00568130063146651 0.0323762550304077 1.08940352309053 0.833333333333333 30.3 30 3 increased growth rate 0.00568130063146651 0.0323762550304077 1.08940352309053 0.833333333333333 30.3 30 3 dilated bile duct 0.00568130063146651 0.0323762550304077 1.08940352309053 0.833333333333333 30.3 30 3 small intestinal inflammation 0.00568130063146651 0.0323762550304077 1.08940352309053 0.833333333333333 30.3 30 3 abnormal vascular endothelial cell development 0.00568130063146651 0.0323762550304077 1.08940352309053 0.833333333333333 30.3 30 3 absent ovary 0.00568130063146651 0.0323762550304077 1.08940352309053 0.833333333333333 30.3 30 3 increased osteosarcoma incidence 0.00568130063146651 0.0323762550304077 1.08940352309053 0.833333333333333 30.3 30 3 abnormal rostral-caudal body axis extension 0.00568130063146651 0.0323762550304077 1.08940352309053 0.833333333333333 30.3 30 3 abnormal cochlear outer hair cell physiology 0.00568130063146651 0.0323762550304077 1.08940352309053 0.833333333333333 30.3 30 3 persistent right dorsal aorta 0.00568130063146651 0.0323762550304077 1.08940352309053 0.833333333333333 30.3 30 3 abnormal pulmonary valve cusp morphology 0.00568130063146651 0.0323762550304077 1.08940352309053 0.833333333333333 30.3 30 3 prenatal growth retardation 0.00568130063146651 0.0323762550304077 1.08940352309053 0.833333333333333 30.3 30 3 abnormal vitelline vein connection 0.00568130063146651 0.0323762550304077 1.08940352309053 0.833333333333333 30.3 30 3 echinocytosis 0.0586013489414497 0.189189948724018 1.08940352309053 0.833333333333333 30.3 30 3 poor arterial differentiation 0.0586013489414497 0.189189948724018 1.08940352309053 0.833333333333333 30.3 30 3 abnormal urethra morphology 0.0586013489414497 0.189189948724018 1.08940352309053 0.833333333333333 30.3 30 3 left-sided isomerism 0.0586013489414497 0.189189948724018 1.08940352309053 0.833333333333333 30.3 30 3 jumpy 0.0586013489414497 0.189189948724018 1.08940352309053 0.833333333333333 30.3 30 3 delayed brain development 0.0586013489414497 0.189189948724018 1.08940352309053 0.833333333333333 30.3 30 3 reduced NMDA-mediated synaptic currents 0.0586013489414497 0.189189948724018 1.08940352309053 0.833333333333333 30.3 30 3 abnormal hepatobiliary system physiology 0.0586013489414497 0.189189948724018 1.08940352309053 0.833333333333333 30.3 30 3 abnormal blood gas level 0.0586013489414497 0.189189948724018 1.08940352309053 0.833333333333333 30.3 30 3 abnormal pulmonary ventilation 0.0586013489414497 0.189189948724018 1.08940352309053 0.833333333333333 30.3 30 3 abnormal lymph node cortex morphology 0.0586013489414497 0.189189948724018 1.08940352309053 0.833333333333333 30.3 30 3 liver cirrhosis 0.0586013489414497 0.189189948724018 1.08940352309053 0.833333333333333 30.3 30 3 extremity edema 0.0586013489414497 0.189189948724018 1.08940352309053 0.833333333333333 30.3 30 3 esophageal atresia 0.0586013489414497 0.189189948724018 1.08940352309053 0.833333333333333 30.3 30 3 decreased liver function 0.0586013489414497 0.189189948724018 1.08940352309053 0.833333333333333 30.3 30 3 enlarged pancreas 0.0586013489414497 0.189189948724018 1.08940352309053 0.833333333333333 30.3 30 3 ureter obstruction 0.0586013489414497 0.189189948724018 1.08940352309053 0.833333333333333 30.3 30 3 matted coat 0.0586013489414497 0.189189948724018 1.08940352309053 0.833333333333333 30.3 30 3 shortened QT interval 0.0586013489414497 0.189189948724018 1.08940352309053 0.833333333333333 30.3 30 3 abnormal motor nerve collateral sprouting 0.0586013489414497 0.189189948724018 1.08940352309053 0.833333333333333 30.3 30 3 short scapula 0.0586013489414497 0.189189948724018 1.08940352309053 0.833333333333333 30.3 30 3 bowed humerus 0.0586013489414497 0.189189948724018 1.08940352309053 0.833333333333333 30.3 30 3 decreased cochlear microphonics 0.0586013489414497 0.189189948724018 1.08940352309053 0.833333333333333 30.3 30 3 absent parietal bone 0.0586013489414497 0.189189948724018 1.08940352309053 0.833333333333333 30.3 30 3 decreased prostate gland weight 0.0586013489414497 0.189189948724018 1.08940352309053 0.833333333333333 30.3 30 3 impaired granulocyte bactericidal activity 0.0586013489414497 0.189189948724018 1.08940352309053 0.833333333333333 30.3 30 3 abnormal heart size 0.0586013489414497 0.189189948724018 1.08940352309053 0.833333333333333 30.3 30 3 abnormal ligament morphology 0.0586013489414497 0.189189948724018 1.08940352309053 0.833333333333333 30.3 30 3 increased renal glomerular filtration rate 0.0586013489414497 0.189189948724018 1.08940352309053 0.833333333333333 30.3 30 3 abnormal eyelid development 0.0586013489414497 0.189189948724018 1.08940352309053 0.833333333333333 30.3 30 3 absent sperm mitochondrial sheath 0.0586013489414497 0.189189948724018 1.08940352309053 0.833333333333333 30.3 30 3 abnormal neural crest cell morphology 0.0586013489414497 0.189189948724018 1.08940352309053 0.833333333333333 30.3 30 3 abnormal aorta tunica adventitia morphology 0.0586013489414497 0.189189948724018 1.08940352309053 0.833333333333333 30.3 30 3 absent tongue 0.0586013489414497 0.189189948724018 1.08940352309053 0.833333333333333 30.3 30 3 abnormal olfactory bulb layer morphology 0.0586013489414497 0.189189948724018 1.08940352309053 0.833333333333333 30.3 30 3 ectopic hippocampus pyramidal cells 0.0586013489414497 0.189189948724018 1.08940352309053 0.833333333333333 30.3 30 3 abnormal oval cell physiology 0.0586013489414497 0.189189948724018 1.08940352309053 0.833333333333333 30.3 30 3 enlarged lymphatic vessel 0.0586013489414497 0.189189948724018 1.08940352309053 0.833333333333333 30.3 30 3 abnormal acute phase protein level 0.0586013489414497 0.189189948724018 1.08940352309053 0.833333333333333 30.3 30 3 cerebral arteriovenous malformation 0.0586013489414497 0.189189948724018 1.08940352309053 0.833333333333333 30.3 30 3 common truncal valve 0.0586013489414497 0.189189948724018 1.08940352309053 0.833333333333333 30.3 30 3 thick myocardium 0.0586013489414497 0.189189948724018 1.08940352309053 0.833333333333333 30.3 30 3 increased total lung capacity 0.0586013489414497 0.189189948724018 1.08940352309053 0.833333333333333 30.3 30 3 podocyte hypertrophy 0.0586013489414497 0.189189948724018 1.08940352309053 0.833333333333333 30.3 30 3 increased bone trabecular spacing 0.0586013489414497 0.189189948724018 1.08940352309053 0.833333333333333 30.3 30 3 absent embryonic telencephalon 0.0586013489414497 0.189189948724018 1.08940352309053 0.833333333333333 30.3 30 3 abnormal vertebral artery origin 0.0586013489414497 0.189189948724018 1.08940352309053 0.833333333333333 30.3 30 3 ectopic bone 0.0586013489414497 0.189189948724018 1.08940352309053 0.833333333333333 30.3 30 3 decreased hippocampus volume 0.0586013489414497 0.189189948724018 1.08940352309053 0.833333333333333 30.3 30 3 decreased capillary density 0.0586013489414497 0.189189948724018 1.08940352309053 0.833333333333333 30.3 30 3 abnormal excitatory synapse morphology 0.0586013489414497 0.189189948724018 1.08940352309053 0.833333333333333 30.3 30 3 atrioventricular septal defect 3.225355909012e-09 1.09157453383229e-07 1.08529256639962 0.830188679245283 30.3 30 3 abnormal liver development 1.83989194205527e-06 3.42826307555242e-05 1.08317836010144 0.828571428571429 30.3 30 3 abnormal dermal layer morphology 1.83989194205527e-06 3.42826307555242e-05 1.08317836010144 0.828571428571429 30.3 30 3 lethality throughout fetal growth and development, incomplete penetrance 1.91795996701495e-27 4.7709254179497e-25 1.08088304860825 0.826815642458101 30.3 30 3 abnormal cell cycle 4.55284611572659e-18 5.26753707575343e-16 1.0799304489767 0.826086956521739 30.3 30 3 abnormal myelin sheath morphology 5.11180044474585e-08 1.32454204232347e-06 1.0799304489767 0.826086956521739 30.3 30 3 incomplete embryo turning 1.45594955229432e-09 5.32599192842959e-08 1.07793611758431 0.824561403508772 30.3 30 3 decreased mean corpuscular hemoglobin 4.21165801873938e-11 2.05421555325769e-09 1.07658701105417 0.823529411764706 30.3 30 3 abnormal direction of heart looping 3.54093766791323e-06 6.18722545624242e-05 1.07658701105417 0.823529411764706 30.3 30 3 abnormal dorsal-ventral axis patterning 0.00118951966016632 0.00944398653315971 1.07658701105417 0.823529411764706 30.3 30 3 abnormal involuntary movement 0.00118951966016632 0.00944398653315971 1.07658701105417 0.823529411764706 30.3 30 3 increased trabecular bone mass 0.00118951966016632 0.00944398653315971 1.07658701105417 0.823529411764706 30.3 30 3 shortened head 2.99678175089369e-05 0.000402945654343138 1.0738406156178 0.821428571428571 30.3 30 3 absent corpus callosum 2.99678175089369e-05 0.000402945654343138 1.0738406156178 0.821428571428571 30.3 30 3 abnormal head morphology 5.30657841568768e-09 1.71430049467833e-07 1.06959618630706 0.818181818181818 30.3 30 3 abnormal tail movements 0.000258171680984259 0.0026000083257018 1.06959618630706 0.818181818181818 30.3 30 3 prolonged PR interval 0.000258171680984259 0.0026000083257018 1.06959618630706 0.818181818181818 30.3 30 3 cleft upper lip 0.000258171680984259 0.0026000083257018 1.06959618630706 0.818181818181818 30.3 30 3 increased mammary gland tumor incidence 0.000258171680984259 0.0026000083257018 1.06959618630706 0.818181818181818 30.3 30 3 premature suture closure 0.0110760746724937 0.0540230112702511 1.06959618630706 0.818181818181818 30.3 30 3 abnormal sphenoid bone morphology 0.0110760746724937 0.0540230112702511 1.06959618630706 0.818181818181818 30.3 30 3 abnormal thrombopoiesis 0.0110760746724937 0.0540230112702511 1.06959618630706 0.818181818181818 30.3 30 3 abnormal stomach epithelium morphology 0.0110760746724937 0.0540230112702511 1.06959618630706 0.818181818181818 30.3 30 3 delayed hepatic development 0.0110760746724937 0.0540230112702511 1.06959618630706 0.818181818181818 30.3 30 3 abnormal glossopharyngeal ganglion morphology 0.0110760746724937 0.0540230112702511 1.06959618630706 0.818181818181818 30.3 30 3 abnormal eye distance/ position 0.0110760746724937 0.0540230112702511 1.06959618630706 0.818181818181818 30.3 30 3 abnormal fear/anxiety-related behavior 0.0110760746724937 0.0540230112702511 1.06959618630706 0.818181818181818 30.3 30 3 retinal detachment 0.0110760746724937 0.0540230112702511 1.06959618630706 0.818181818181818 30.3 30 3 pharyngeal arch hypoplasia 0.0110760746724937 0.0540230112702511 1.06959618630706 0.818181818181818 30.3 30 3 increased motor neuron number 0.0110760746724937 0.0540230112702511 1.06959618630706 0.818181818181818 30.3 30 3 abnormal dorsal-ventral polarity of the somites 0.0110760746724937 0.0540230112702511 1.06959618630706 0.818181818181818 30.3 30 3 abnormal Bruch membrane morphology 0.0110760746724937 0.0540230112702511 1.06959618630706 0.818181818181818 30.3 30 3 ataxia 3.27815546608451e-29 1.08725489625136e-26 1.06783117609863 0.816831683168317 30.3 30 3 axon degeneration 1.00738879396964e-08 3.0559507621945e-07 1.06519455591074 0.814814814814815 30.3 30 3 abnormal heart valve morphology 5.72638355852197e-05 0.00070169355181396 1.06519455591074 0.814814814814815 30.3 30 3 abnormal atrioventricular cushion morphology 5.72638355852197e-05 0.00070169355181396 1.06519455591074 0.814814814814815 30.3 30 3 abnormal fetal cardiomyocyte proliferation 5.72638355852197e-05 0.00070169355181396 1.06519455591074 0.814814814814815 30.3 30 3 thick interventricular septum 5.72638355852197e-05 0.00070169355181396 1.06519455591074 0.814814814814815 30.3 30 3 decreased bone ossification 5.72638355852197e-05 0.00070169355181396 1.06519455591074 0.814814814814815 30.3 30 3 domed cranium 6.82107146137974e-11 3.17147948788451e-09 1.06450287113417 0.814285714285714 30.3 30 3 embryonic lethality between somite formation and embryo turning, complete penetrance 6.82107146137974e-11 3.17147948788451e-09 1.06450287113417 0.814285714285714 30.3 30 3 absent mandible 0.00228663081598212 0.0157999837632098 1.06216843501326 0.8125 30.3 30 3 vasculature congestion 0.00228663081598212 0.0157999837632098 1.06216843501326 0.8125 30.3 30 3 increased intestinal adenocarcinoma incidence 0.00228663081598212 0.0157999837632098 1.06216843501326 0.8125 30.3 30 3 kidney degeneration 0.00228663081598212 0.0157999837632098 1.06216843501326 0.8125 30.3 30 3 abnormal thoracic cage shape 0.00228663081598212 0.0157999837632098 1.06216843501326 0.8125 30.3 30 3 abnormal embryonic neuroepithelium morphology 4.43577886962592e-09 1.46145694545622e-07 1.05935101210872 0.810344827586207 30.3 30 3 spina bifida 6.71630237694617e-07 1.4158306917503e-05 1.05827770814508 0.80952380952381 30.3 30 3 increased incidence of induced tumors 0.000492272747734027 0.00451023373844712 1.05827770814508 0.80952380952381 30.3 30 3 left pulmonary isomerism 0.000492272747734027 0.00451023373844712 1.05827770814508 0.80952380952381 30.3 30 3 abnormal tumor vascularization 0.000492272747734027 0.00451023373844712 1.05827770814508 0.80952380952381 30.3 30 3 abnormal erythropoiesis 2.77526914459204e-15 2.46552928470453e-13 1.05827770814508 0.80952380952381 30.3 30 3 small liver 1.3370605659433e-11 7.00197506901884e-10 1.05588341468774 0.807692307692308 30.3 30 3 distended pericardium 3.58701787482419e-08 9.49224145066508e-07 1.05588341468774 0.807692307692308 30.3 30 3 abnormal placenta vasculature 3.58701787482419e-08 9.49224145066508e-07 1.05588341468774 0.807692307692308 30.3 30 3 kinked neural tube 3.58701787482419e-08 9.49224145066508e-07 1.05588341468774 0.807692307692308 30.3 30 3 abnormal nasal bone morphology 0.00010861310363352 0.00122528387885887 1.05588341468774 0.807692307692308 30.3 30 3 increased thymocyte apoptosis 0.00010861310363352 0.00122528387885887 1.05588341468774 0.807692307692308 30.3 30 3 pale yolk sac 3.14671129804492e-12 1.84175161267923e-10 1.05527762959612 0.807228915662651 30.3 30 3 small cranium 2.43533744592519e-05 0.000337487570848964 1.05426147395857 0.806451612903226 30.3 30 3 Leydig cell hyperplasia 1.26307313921545e-06 2.47393262503814e-05 1.05220437839963 0.804878048780488 30.3 30 3 abnormal allantois morphology 2.9072719333191e-07 6.75872797582361e-06 1.0515112266352 0.804347826086957 30.3 30 3 abnormal vitelline vasculature morphology 8.36566247388811e-16 8.09312968588861e-14 1.0458273821669 0.8 30.3 30 3 abnormal lung development 4.81900359930063e-12 2.6937688659012e-10 1.0458273821669 0.8 30.3 30 3 increased erythrocyte cell number 6.78825517970331e-09 2.110723094939e-07 1.0458273821669 0.8 30.3 30 3 abnormal interventricular septum morphology 1.25550160108795e-07 3.13875400271987e-06 1.0458273821669 0.8 30.3 30 3 abnormal hippocampus pyramidal cell morphology 1.03451205713451e-05 0.000156434573989185 1.0458273821669 0.8 30.3 30 3 disorganized myocardium 4.57035485984014e-05 0.000578562733529381 1.0458273821669 0.8 30.3 30 3 abnormal brain vasculature morphology 4.57035485984014e-05 0.000578562733529381 1.0458273821669 0.8 30.3 30 3 abnormal lens epithelium morphology 0.000929732451074836 0.0075826540067169 1.0458273821669 0.8 30.3 30 3 abnormal physiological neovascularization 0.000929732451074836 0.0075826540067169 1.0458273821669 0.8 30.3 30 3 abnormal heart right ventricle morphology 0.000929732451074836 0.0075826540067169 1.0458273821669 0.8 30.3 30 3 dilated vasculature 0.000929732451074836 0.0075826540067169 1.0458273821669 0.8 30.3 30 3 abnormal response to tactile stimuli 0.000929732451074836 0.0075826540067169 1.0458273821669 0.8 30.3 30 3 decreased muscle cell glucose uptake 0.000929732451074836 0.0075826540067169 1.0458273821669 0.8 30.3 30 3 decreased hepatocyte number 0.00434405962413092 0.0259133053118122 1.0458273821669 0.8 30.3 30 3 absent egg cylinders 0.00434405962413092 0.0259133053118122 1.0458273821669 0.8 30.3 30 3 abnormal placenta size 0.00434405962413092 0.0259133053118122 1.0458273821669 0.8 30.3 30 3 herniated liver 0.00434405962413092 0.0259133053118122 1.0458273821669 0.8 30.3 30 3 retarded hair growth 0.0212624506722475 0.0898731453648523 1.0458273821669 0.8 30.3 30 3 kidney hemorrhage 0.0212624506722475 0.0898731453648523 1.0458273821669 0.8 30.3 30 3 fused cornea and lens 0.0212624506722475 0.0898731453648523 1.0458273821669 0.8 30.3 30 3 abnormal immune cell physiology 0.0212624506722475 0.0898731453648523 1.0458273821669 0.8 30.3 30 3 impaired social transmission of food preference 0.0212624506722475 0.0898731453648523 1.0458273821669 0.8 30.3 30 3 abnormal bone healing 0.0212624506722475 0.0898731453648523 1.0458273821669 0.8 30.3 30 3 acrania 0.0212624506722475 0.0898731453648523 1.0458273821669 0.8 30.3 30 3 peritoneal inflammation 0.0212624506722475 0.0898731453648523 1.0458273821669 0.8 30.3 30 3 abnormal reproductive system development 0.0212624506722475 0.0898731453648523 1.0458273821669 0.8 30.3 30 3 abnormal utricular macula morphology 0.0212624506722475 0.0898731453648523 1.0458273821669 0.8 30.3 30 3 abnormal corneal endothelium morphology 0.0212624506722475 0.0898731453648523 1.0458273821669 0.8 30.3 30 3 increased susceptibility to atherosclerosis 0.0212624506722475 0.0898731453648523 1.0458273821669 0.8 30.3 30 3 umbilical hernia 0.0212624506722475 0.0898731453648523 1.0458273821669 0.8 30.3 30 3 abnormal vibrissa follicle morphology 0.0212624506722475 0.0898731453648523 1.0458273821669 0.8 30.3 30 3 thin ventricle myocardium compact layer 0.0212624506722475 0.0898731453648523 1.0458273821669 0.8 30.3 30 3 thick aortic valve cusps 0.0212624506722475 0.0898731453648523 1.0458273821669 0.8 30.3 30 3 thick aortic valve 0.0212624506722475 0.0898731453648523 1.0458273821669 0.8 30.3 30 3 abnormal pulmonary interalveolar septum morphology 0.0212624506722475 0.0898731453648523 1.0458273821669 0.8 30.3 30 3 abnormal cell morphology 1.55236548995707e-15 1.43018857639564e-13 1.04353390106566 0.798245614035088 30.3 30 3 short snout 1.21459864832614e-14 1.02417428396992e-12 1.04098558873095 0.796296296296296 30.3 30 3 abnormal neuronal precursor proliferation 5.41308520810823e-08 1.39534191245277e-06 1.04098558873095 0.796296296296296 30.3 30 3 omphalocele 1.0096540338106e-06 2.03361490615698e-05 1.03988518113187 0.795454545454545 30.3 30 3 impaired macrophage chemotaxis 4.39373272586521e-06 7.40976959700998e-05 1.03912336048635 0.794871794871795 30.3 30 3 impaired synaptic plasticity 1.92532406521941e-05 0.000270578735154423 1.03813747494509 0.794117647058823 30.3 30 3 abnormal myocardial fiber morphology 4.01173095713495e-13 2.66111486823285e-11 1.03774108797489 0.793814432989691 30.3 30 3 abnormal forebrain development 5.51498056732619e-10 2.177541930353e-08 1.034933346936 0.791666666666667 30.3 30 3 decreased body height 0.000381199785307885 0.00362096423817257 1.034933346936 0.791666666666667 30.3 30 3 abnormal nursing 0.000381199785307885 0.00362096423817257 1.034933346936 0.791666666666667 30.3 30 3 increased stereotypic behavior 0.000381199785307885 0.00362096423817257 1.034933346936 0.791666666666667 30.3 30 3 abnormal cardiac muscle contractility 0.000381199785307885 0.00362096423817257 1.034933346936 0.791666666666667 30.3 30 3 abnormal left-right axis patterning 1.86666539022744e-06 3.46517175984384e-05 1.03366659865334 0.790697674418605 30.3 30 3 increased neuron apoptosis 5.61463438128312e-11 2.68584673527726e-09 1.03291593300435 0.790123456790123 30.3 30 3 decreased neuron apoptosis 8.12233488389454e-06 0.000126672777577979 1.03206649555945 0.789473684210526 30.3 30 3 kyphoscoliosis 0.00173755564181921 0.0124200277558198 1.03206649555945 0.789473684210526 30.3 30 3 small superior vagus ganglion 0.00173755564181921 0.0124200277558198 1.03206649555945 0.789473684210526 30.3 30 3 abnormal stationary movement 0.00173755564181921 0.0124200277558198 1.03206649555945 0.789473684210526 30.3 30 3 unresponsive to tactile stimuli 0.00173755564181921 0.0124200277558198 1.03206649555945 0.789473684210526 30.3 30 3 increased left ventricle weight 0.00173755564181921 0.0124200277558198 1.03206649555945 0.789473684210526 30.3 30 3 abnormal sternebra morphology 0.00173755564181921 0.0124200277558198 1.03206649555945 0.789473684210526 30.3 30 3 increased liver cholesterol level 0.00173755564181921 0.0124200277558198 1.03206649555945 0.789473684210526 30.3 30 3 decreased embryo size 1.68832124669016e-57 1.39989970038059e-54 1.03105889925974 0.788702928870293 30.3 30 3 abnormal QRS complex 3.55877157965358e-05 0.000469625692540493 1.02998151274013 0.787878787878788 30.3 30 3 anophthalmia 1.05037621342802e-11 5.55917198064298e-10 1.02820107797308 0.786516853932584 30.3 30 3 abnormal optic nerve morphology 3.43169711145856e-06 6.0327537560093e-05 1.02715189319964 0.785714285714286 30.3 30 3 lymphoid hyperplasia 0.000157349235198258 0.0016960329570058 1.02715189319964 0.785714285714286 30.3 30 3 abnormal somite shape 0.000157349235198258 0.0016960329570058 1.02715189319964 0.785714285714286 30.3 30 3 straub tail 0.000157349235198258 0.0016960329570058 1.02715189319964 0.785714285714286 30.3 30 3 prolonged QRS complex duration 0.000157349235198258 0.0016960329570058 1.02715189319964 0.785714285714286 30.3 30 3 subcutaneous edema 0.000157349235198258 0.0016960329570058 1.02715189319964 0.785714285714286 30.3 30 3 abnormal blood flow velocity 0.00814288093943273 0.041936679786416 1.02715189319964 0.785714285714286 30.3 30 3 megacephaly 0.00814288093943273 0.041936679786416 1.02715189319964 0.785714285714286 30.3 30 3 abnormal placing response 0.00814288093943273 0.041936679786416 1.02715189319964 0.785714285714286 30.3 30 3 absent visceral yolk sac blood islands 0.00814288093943273 0.041936679786416 1.02715189319964 0.785714285714286 30.3 30 3 abnormal adrenal gland secretion 0.00814288093943273 0.041936679786416 1.02715189319964 0.785714285714286 30.3 30 3 abnormal fluid regulation 0.00814288093943273 0.041936679786416 1.02715189319964 0.785714285714286 30.3 30 3 vascular smooth muscle hypoplasia 0.00814288093943273 0.041936679786416 1.02715189319964 0.785714285714286 30.3 30 3 premature hair loss 0.00814288093943273 0.041936679786416 1.02715189319964 0.785714285714286 30.3 30 3 decreased cornea thickness 0.00814288093943273 0.041936679786416 1.02715189319964 0.785714285714286 30.3 30 3 decreased tongue size 0.00814288093943273 0.041936679786416 1.02715189319964 0.785714285714286 30.3 30 3 abnormal visceral yolk sac morphology 1.88119322200452e-10 7.86465233569116e-09 1.02596990022703 0.784810126582278 30.3 30 3 abnormal nervous system morphology 1.88119322200452e-10 7.86465233569116e-09 1.02596990022703 0.784810126582278 30.3 30 3 abnormal angiogenesis 7.97314607123955e-10 3.0795572836667e-08 1.02462817847433 0.783783783783784 30.3 30 3 malocclusion 1.49199331812939e-05 0.000215149761092572 1.02462817847433 0.783783783783784 30.3 30 3 abnormal vocalization 1.49199331812939e-05 0.000215149761092572 1.02462817847433 0.783783783783784 30.3 30 3 decreased width of hypertrophic chondrocyte zone 1.49199331812939e-05 0.000215149761092572 1.02462817847433 0.783783783783784 30.3 30 3 abnormal locomotor behavior 8.26685017674955e-12 4.51951424498121e-10 1.02309200429371 0.782608695652174 30.3 30 3 abnormal ulna morphology 0.000704376517621132 0.00605228527662371 1.02309200429371 0.782608695652174 30.3 30 3 abnormal corneal stroma morphology 0.000704376517621132 0.00605228527662371 1.02309200429371 0.782608695652174 30.3 30 3 abnormal hematopoietic stem cell physiology 0.000704376517621132 0.00605228527662371 1.02309200429371 0.782608695652174 30.3 30 3 preweaning lethality, incomplete penetrance 1.39654116498296e-47 7.7197692175447e-45 1.0228140656889 0.78239608801956 30.3 30 3 abnormal embryo turning 1.4367020374359e-07 3.52098159420867e-06 1.02205857802675 0.781818181818182 30.3 30 3 abnormal platelet physiology 1.4367020374359e-07 3.52098159420867e-06 1.02205857802675 0.781818181818182 30.3 30 3 scoliosis 6.53031508220313e-05 0.000788551396455353 1.02131580289737 0.78125 30.3 30 3 kidney cortex cysts 6.53031508220313e-05 0.000788551396455353 1.02131580289737 0.78125 30.3 30 3 abnormal developmental patterning 1.47234619611359e-10 6.36949767449138e-09 1.020319397236 0.780487804878049 30.3 30 3 thick ventricular wall 6.27155831756134e-06 0.00010032476729861 1.020319397236 0.780487804878049 30.3 30 3 palatal shelves fail to meet at midline 6.27155831756134e-06 0.00010032476729861 1.020319397236 0.780487804878049 30.3 30 3 pericardial edema 6.14759494584127e-09 1.95719718048988e-07 1.01891270689055 0.779411764705882 30.3 30 3 abnormal embryo size 6.7977881468049e-14 4.7632388775147e-12 1.01806205343681 0.778761061946903 30.3 30 3 abnormal heart development 7.93005860979158e-19 1.0115908098388e-16 1.01769594941874 0.778481012658228 30.3 30 3 abnormal neural tube morphology 3.42738545801695e-19 4.60844396044171e-17 1.01677662155116 0.777777777777778 30.3 30 3 heart right ventricle hypertrophy 2.72228130406156e-05 0.000371050670896062 1.01677662155116 0.777777777777778 30.3 30 3 reduced long term depression 2.72228130406156e-05 0.000371050670896062 1.01677662155116 0.777777777777778 30.3 30 3 lowered ear position 0.00320961557651012 0.0205242127161155 1.01677662155116 0.777777777777778 30.3 30 3 abnormal mammary gland morphology 0.00320961557651012 0.0205242127161155 1.01677662155116 0.777777777777778 30.3 30 3 blepharoptosis 0.00320961557651012 0.0205242127161155 1.01677662155116 0.777777777777778 30.3 30 3 abnormal bile duct morphology 0.00320961557651012 0.0205242127161155 1.01677662155116 0.777777777777778 30.3 30 3 abnormal metacarpal bone morphology 0.00320961557651012 0.0205242127161155 1.01677662155116 0.777777777777778 30.3 30 3 absent ureter 0.00320961557651012 0.0205242127161155 1.01677662155116 0.777777777777778 30.3 30 3 long tibia 0.00320961557651012 0.0205242127161155 1.01677662155116 0.777777777777778 30.3 30 3 abnormal glycogen homeostasis 0.00320961557651012 0.0205242127161155 1.01677662155116 0.777777777777778 30.3 30 3 decreased lactate dehydrogenase level 0.00320961557651012 0.0205242127161155 1.01677662155116 0.777777777777778 30.3 30 3 decreased pulmonary respiratory rate 0.00320961557651012 0.0205242127161155 1.01677662155116 0.777777777777778 30.3 30 3 abnormal pregnancy 0.00320961557651012 0.0205242127161155 1.01677662155116 0.777777777777778 30.3 30 3 increased effector memory CD4-positive, alpha-beta T cell number 0.00320961557651012 0.0205242127161155 1.01677662155116 0.777777777777778 30.3 30 3 increased effector memory CD8-positive, alpha-beta T cell number 0.00320961557651012 0.0205242127161155 1.01677662155116 0.777777777777778 30.3 30 3 heart hyperplasia 0.0400681532120215 0.14087566235322 1.01677662155116 0.777777777777778 30.3 30 3 distorted hair follicle pattern 0.0400681532120215 0.14087566235322 1.01677662155116 0.777777777777778 30.3 30 3 abnormal sympathetic neuron morphology 0.0400681532120215 0.14087566235322 1.01677662155116 0.777777777777778 30.3 30 3 abnormal cholinergic neuron morphology 0.0400681532120215 0.14087566235322 1.01677662155116 0.777777777777778 30.3 30 3 abnormal kindling response 0.0400681532120215 0.14087566235322 1.01677662155116 0.777777777777778 30.3 30 3 multifocal hepatic necrosis 0.0400681532120215 0.14087566235322 1.01677662155116 0.777777777777778 30.3 30 3 abnormal vomeronasal organ morphology 0.0400681532120215 0.14087566235322 1.01677662155116 0.777777777777778 30.3 30 3 abnormal NMDA-mediated synaptic currents 0.0400681532120215 0.14087566235322 1.01677662155116 0.777777777777778 30.3 30 3 abnormal abdominal wall morphology 0.0400681532120215 0.14087566235322 1.01677662155116 0.777777777777778 30.3 30 3 pancreas cysts 0.0400681532120215 0.14087566235322 1.01677662155116 0.777777777777778 30.3 30 3 abnormal artery development 0.0400681532120215 0.14087566235322 1.01677662155116 0.777777777777778 30.3 30 3 premature neuronal precursor differentiation 0.0400681532120215 0.14087566235322 1.01677662155116 0.777777777777778 30.3 30 3 decreased fear-related response 0.0400681532120215 0.14087566235322 1.01677662155116 0.777777777777778 30.3 30 3 abnormal thymus physiology 0.0400681532120215 0.14087566235322 1.01677662155116 0.777777777777778 30.3 30 3 abnormal proprioceptive neuron morphology 0.0400681532120215 0.14087566235322 1.01677662155116 0.777777777777778 30.3 30 3 decreased vestibular hair cell number 0.0400681532120215 0.14087566235322 1.01677662155116 0.777777777777778 30.3 30 3 small scapula 0.0400681532120215 0.14087566235322 1.01677662155116 0.777777777777778 30.3 30 3 increased neuronal precursor cell number 0.0400681532120215 0.14087566235322 1.01677662155116 0.777777777777778 30.3 30 3 decreased thyroid-stimulating hormone level 0.0400681532120215 0.14087566235322 1.01677662155116 0.777777777777778 30.3 30 3 liver hyperplasia 0.0400681532120215 0.14087566235322 1.01677662155116 0.777777777777778 30.3 30 3 decreased susceptibility to atherosclerosis 0.0400681532120215 0.14087566235322 1.01677662155116 0.777777777777778 30.3 30 3 positive geotaxis 0.0400681532120215 0.14087566235322 1.01677662155116 0.777777777777778 30.3 30 3 abnormal leukopoiesis 0.0400681532120215 0.14087566235322 1.01677662155116 0.777777777777778 30.3 30 3 abnormal liver vasculature morphology 0.0400681532120215 0.14087566235322 1.01677662155116 0.777777777777778 30.3 30 3 abnormal hyoid bone lesser horn morphology 0.0400681532120215 0.14087566235322 1.01677662155116 0.777777777777778 30.3 30 3 abnormal hippocampus granule cell morphology 0.0400681532120215 0.14087566235322 1.01677662155116 0.777777777777778 30.3 30 3 abnormal cerebellar layer morphology 0.0400681532120215 0.14087566235322 1.01677662155116 0.777777777777778 30.3 30 3 abnormal telomere morphology 0.0400681532120215 0.14087566235322 1.01677662155116 0.777777777777778 30.3 30 3 fusion of atlas and occipital bones 0.0400681532120215 0.14087566235322 1.01677662155116 0.777777777777778 30.3 30 3 decreased effector memory CD4-positive, alpha-beta T cell number 0.0400681532120215 0.14087566235322 1.01677662155116 0.777777777777778 30.3 30 3 abnormal pulmonary alveolar system morphology 0.0400681532120215 0.14087566235322 1.01677662155116 0.777777777777778 30.3 30 3 abnormal lung lobe morphology 0.0400681532120215 0.14087566235322 1.01677662155116 0.777777777777778 30.3 30 3 decreased pancreatic beta cell proliferation 0.0400681532120215 0.14087566235322 1.01677662155116 0.777777777777778 30.3 30 3 trigeminal neuroma 0.0400681532120215 0.14087566235322 1.01677662155116 0.777777777777778 30.3 30 3 abnormal coronary sinus connection 0.0400681532120215 0.14087566235322 1.01677662155116 0.777777777777778 30.3 30 3 symmetric azygos veins 0.0400681532120215 0.14087566235322 1.01677662155116 0.777777777777778 30.3 30 3 increased endoplasmic reticulum stress 0.0400681532120215 0.14087566235322 1.01677662155116 0.777777777777778 30.3 30 3 decreased platelet dense granule number 0.0400681532120215 0.14087566235322 1.01677662155116 0.777777777777778 30.3 30 3 embryonic lethality during organogenesis, complete penetrance 1.18301896245795e-62 1.47137983455707e-59 1.0154797125951 0.776785714285714 30.3 30 3 abnormal brain morphology 6.18717370324858e-19 8.10031294043729e-17 1.01497222648186 0.77639751552795 30.3 30 3 preweaning lethality, complete penetrance 4.41313135460314e-82 7.31844282971687e-79 1.01402857662805 0.775675675675676 30.3 30 3 embryonic lethality between implantation and somite formation, complete penetrance 6.48274136091153e-28 1.69745464581763e-25 1.01381225822302 0.775510204081633 30.3 30 3 abnormal long bone hypertrophic chondrocyte zone 1.11550406967381e-06 2.21100906240128e-05 1.01381225822302 0.775510204081633 30.3 30 3 pericardial effusion 4.71258687788663e-08 1.24048252473471e-06 1.01209101500023 0.774193548387097 30.3 30 3 abnormal postnatal growth/weight/body size 0.000118904145646913 0.00133231559593106 1.01209101500023 0.774193548387097 30.3 30 3 lethality throughout fetal growth and development, complete penetrance 9.5743219308661e-22 1.58774172020196e-19 1.01142516564826 0.773684210526316 30.3 30 3 decreased cell proliferation 3.98986530854154e-21 6.20299372187317e-19 1.01049537601262 0.772972972972973 30.3 30 3 abnormal germ layer development 0.00128821637468324 0.00992086139945684 1.01017417595667 0.772727272727273 30.3 30 3 abnormal vascular branching morphogenesis 0.00128821637468324 0.00992086139945684 1.01017417595667 0.772727272727273 30.3 30 3 abnormal channel response 0.00128821637468324 0.00992086139945684 1.01017417595667 0.772727272727273 30.3 30 3 increased circulating creatine kinase level 0.00128821637468324 0.00992086139945684 1.01017417595667 0.772727272727273 30.3 30 3 embryonic lethality before implantation, incomplete penetrance 0.00128821637468324 0.00992086139945684 1.01017417595667 0.772727272727273 30.3 30 3 impaired humoral immune response 0.00128821637468324 0.00992086139945684 1.01017417595667 0.772727272727273 30.3 30 3 abnormal blood vessel morphology 8.08436176950957e-17 8.37910412568961e-15 1.00976436898874 0.772413793103448 30.3 30 3 decreased brain weight 1.99830986940024e-07 4.77961134628183e-06 1.00913168454701 0.771929824561403 30.3 30 3 decreased circulating thyroxine level 4.93181459250594e-05 0.000619590343376693 1.00847640423237 0.771428571428571 30.3 30 3 decreased bone mineralization 4.93181459250594e-05 0.000619590343376693 1.00847640423237 0.771428571428571 30.3 30 3 overriding aortic valve 2.01166284530954e-06 3.72045451874163e-05 1.00769825885874 0.770833333333333 30.3 30 3 decreased erythrocyte cell number 6.45336154033657e-18 7.29669855981237e-16 1.00752478696016 0.770700636942675 30.3 30 3 increased embryonic tissue cell apoptosis 1.55305427092866e-09 5.59887318686237e-08 1.00560325208356 0.769230769230769 30.3 30 3 abnormal snout morphology 8.48423970868907e-07 1.75141462866092e-05 1.00560325208356 0.769230769230769 30.3 30 3 increased hepatocyte apoptosis 2.05510087439924e-05 0.000286390107846953 1.00560325208356 0.769230769230769 30.3 30 3 decreased B-1 B cell number 2.05510087439924e-05 0.000286390107846953 1.00560325208356 0.769230769230769 30.3 30 3 abnormal xiphoid process morphology 0.000523530437220285 0.00476140067891955 1.00560325208356 0.769230769230769 30.3 30 3 ventricular hypoplasia 0.000523530437220285 0.00476140067891955 1.00560325208356 0.769230769230769 30.3 30 3 absent common myeloid progenitor cells 0.0150314787110671 0.0674832981135019 1.00560325208356 0.769230769230769 30.3 30 3 absent myocardial trabeculae 0.0150314787110671 0.0674832981135019 1.00560325208356 0.769230769230769 30.3 30 3 abnormal sympathetic ganglion morphology 0.0150314787110671 0.0674832981135019 1.00560325208356 0.769230769230769 30.3 30 3 excessive scratching 0.0150314787110671 0.0674832981135019 1.00560325208356 0.769230769230769 30.3 30 3 increased pituitary adenoma incidence 0.0150314787110671 0.0674832981135019 1.00560325208356 0.769230769230769 30.3 30 3 abnormal lung interstitium morphology 0.0150314787110671 0.0674832981135019 1.00560325208356 0.769230769230769 30.3 30 3 abnormal coping response 0.0150314787110671 0.0674832981135019 1.00560325208356 0.769230769230769 30.3 30 3 abnormal soleus morphology 0.0150314787110671 0.0674832981135019 1.00560325208356 0.769230769230769 30.3 30 3 abnormal telomere length 0.0150314787110671 0.0674832981135019 1.00560325208356 0.769230769230769 30.3 30 3 abnormal retinal inner plexiform layer morphology 0.0150314787110671 0.0674832981135019 1.00560325208356 0.769230769230769 30.3 30 3 abnormal vertebral arch development 0.0150314787110671 0.0674832981135019 1.00560325208356 0.769230769230769 30.3 30 3 decreased cardiac stroke volume 0.0150314787110671 0.0674832981135019 1.00560325208356 0.769230769230769 30.3 30 3 embryonic growth arrest 3.76801899817069e-25 7.49835780635967e-23 1.00472499596821 0.768558951965066 30.3 30 3 astrocytosis 6.51279063303789e-09 2.05070464552934e-07 1.00284817468059 0.767123287671233 30.3 30 3 increased metastatic potential 0.000214713155980026 0.0022394087023074 1.00225124124328 0.766666666666667 30.3 30 3 increased cellular sensitivity to gamma-irradiation 3.60716090684104e-06 6.26512852595775e-05 1.00132408930874 0.765957446808511 30.3 30 3 increased circulating alkaline phosphatase level 6.78138184447932e-18 7.4971943725077e-16 1.00063731009796 0.765432098765432 30.3 30 3 abnormal extraembryonic tissue morphology 9.4621696118865e-12 5.11677106729732e-10 0.999687938836012 0.764705882352941 30.3 30 3 abnormal dendritic spine morphology 1.51767774358615e-06 2.92652975749656e-05 0.999687938836012 0.764705882352941 30.3 30 3 short maxilla 8.8674760015647e-05 0.00101649062460333 0.999687938836012 0.764705882352941 30.3 30 3 abnormal bone marrow cavity morphology 0.00585224207238344 0.0330851185342132 0.999687938836012 0.764705882352941 30.3 30 3 abnormal interatrial septum morphology 0.00585224207238344 0.0330851185342132 0.999687938836012 0.764705882352941 30.3 30 3 abnormal glutamate-mediated receptor currents 0.00585224207238344 0.0330851185342132 0.999687938836012 0.764705882352941 30.3 30 3 abnormal ectoplacental cone morphology 0.00585224207238344 0.0330851185342132 0.999687938836012 0.764705882352941 30.3 30 3 decreased growth hormone level 0.00585224207238344 0.0330851185342132 0.999687938836012 0.764705882352941 30.3 30 3 abnormal rostral-caudal axis patterning 6.40004682631482e-07 1.36069371627847e-05 0.998289773886591 0.763636363636364 30.3 30 3 persistence of hyaloid vascular system 3.68233054729142e-05 0.000482094591388811 0.997664279040797 0.763157894736842 30.3 30 3 incomplete somite formation 3.68233054729142e-05 0.000482094591388811 0.997664279040797 0.763157894736842 30.3 30 3 decreased total retina thickness 3.68233054729142e-05 0.000482094591388811 0.997664279040797 0.763157894736842 30.3 30 3 decreased body length 8.3897834194807e-29 2.31884291732869e-26 0.997162056901839 0.762773722627737 30.3 30 3 increased heart weight 2.59999282860196e-15 2.35181169496268e-13 0.9969217851591 0.762589928057554 30.3 30 3 decreased grip strength 2.78623503186841e-23 4.77983423570528e-21 0.996878840307495 0.762557077625571 30.3 30 3 abnormal posture 2.10169907346814e-09 7.28207420574816e-08 0.996804223627831 0.7625 30.3 30 3 abnormal scapula morphology 0.00232960350176542 0.0159858998914248 0.996026078254195 0.761904761904762 30.3 30 3 abnormal eye pigmentation 0.00232960350176542 0.0159858998914248 0.996026078254195 0.761904761904762 30.3 30 3 liver degeneration 0.00232960350176542 0.0159858998914248 0.996026078254195 0.761904761904762 30.3 30 3 complete atrioventricular septal defect 0.00232960350176542 0.0159858998914248 0.996026078254195 0.761904761904762 30.3 30 3 embryonic lethality at implantation, complete penetrance 0.00232960350176542 0.0159858998914248 0.996026078254195 0.761904761904762 30.3 30 3 internal hemorrhage 4.85147279264175e-08 1.26366896038705e-06 0.995096949449853 0.761194029850746 30.3 30 3 retinal degeneration 6.95782150277394e-11 3.20510759039818e-09 0.994080714820105 0.760416666666667 30.3 30 3 pallor 1.283072741391e-18 1.55689924107811e-16 0.993536013058559 0.76 30.3 30 3 short stride length 2.69978491978503e-06 4.79693927711804e-05 0.993536013058559 0.76 30.3 30 3 decreased circulating alkaline phosphatase level 2.69978491978503e-06 4.79693927711804e-05 0.993536013058559 0.76 30.3 30 3 mandible hypoplasia 0.000941182123245348 0.00765094944958432 0.993536013058559 0.76 30.3 30 3 neurodegeneration 1.13653981012258e-06 2.24376410926977e-05 0.992567654371368 0.759259259259259 30.3 30 3 abnormal parietal bone morphology 0.00038429530005128 0.00362096423817257 0.991732862399651 0.758620689655172 30.3 30 3 abnormal microglial cell morphology 0.00038429530005128 0.00362096423817257 0.991732862399651 0.758620689655172 30.3 30 3 lordosis 0.00038429530005128 0.00362096423817257 0.991732862399651 0.758620689655172 30.3 30 3 abnormal outer ear morphology 0.00038429530005128 0.00362096423817257 0.991732862399651 0.758620689655172 30.3 30 3 abnormal embryonic erythropoiesis 0.00038429530005128 0.00362096423817257 0.991732862399651 0.758620689655172 30.3 30 3 increased grip strength 2.87880386663282e-10 1.16439424686978e-08 0.991237491339511 0.758241758241758 30.3 30 3 abnormal aorta morphology 0.000158163885276704 0.0016960329570058 0.990366839173205 0.757575757575758 30.3 30 3 belly spot 0.000158163885276704 0.0016960329570058 0.990366839173205 0.757575757575758 30.3 30 3 double outlet right ventricle 9.57306778218173e-12 5.12107658240367e-10 0.989626377985038 0.757009345794392 30.3 30 3 abnormal hepatocyte morphology 4.09290159864412e-12 2.3138847105971e-10 0.989296172320045 0.756756756756757 30.3 30 3 pale liver 1.54474031384395e-08 4.49420062068636e-07 0.989296172320045 0.756756756756757 30.3 30 3 hydroencephaly 1.75057135451383e-12 1.08863656108829e-10 0.988988937483921 0.756521739130435 30.3 30 3 edema 7.00939218553527e-18 7.58081002674738e-16 0.988063660477454 0.755813953488372 30.3 30 3 abnormal ectoderm development 1.13894477531215e-05 0.000168638400511249 0.98772586093541 0.755555555555556 30.3 30 3 cardiomyopathy 1.13894477531215e-05 0.000168638400511249 0.98772586093541 0.755555555555556 30.3 30 3 decreased birth body size 3.07420306136269e-12 1.82073336074754e-10 0.986196873534581 0.754385964912281 30.3 30 3 absent vitelline blood vessels 8.45923416694646e-07 1.75141462866092e-05 0.986196873534581 0.754385964912281 30.3 30 3 abnormal cranium morphology 4.41468599887771e-14 3.32773679460857e-12 0.985341097004267 0.753731343283582 30.3 30 3 microcephaly 6.40199986026911e-08 1.64174996416695e-06 0.985199707838389 0.753623188405797 30.3 30 3 hemorrhage 1.61163318402719e-23 2.96958336686491e-21 0.984635354486926 0.753191489361702 30.3 30 3 embryonic lethality, complete penetrance 2.99260260530979e-31 1.35347254194693e-28 0.983536723040976 0.752351097178683 30.3 30 3 myoclonus 0.000681294461615509 0.00589467816789071 0.980463170781473 0.75 30.3 30 3 abnormal renal tubule epithelium morphology 0.000681294461615509 0.00589467816789071 0.980463170781473 0.75 30.3 30 3 abnormal embryo development 5.77308080727589e-14 4.16247492988371e-12 0.980463170781473 0.75 30.3 30 3 ventricular septal defect 5.77308080727589e-14 4.16247492988371e-12 0.980463170781473 0.75 30.3 30 3 hydrops fetalis 4.75528277762974e-08 1.24513325361621e-06 0.980463170781473 0.75 30.3 30 3 absent mesoderm 6.26409106872375e-07 1.33750442347213e-05 0.980463170781473 0.75 30.3 30 3 abnormal spongiotrophoblast layer morphology 0.000279707130121558 0.00278866327125201 0.980463170781473 0.75 30.3 30 3 abnormal auditory brainstem response waveform shape 0.000279707130121558 0.00278866327125201 0.980463170781473 0.75 30.3 30 3 disorganized retinal layers 0.0105163460485773 0.051955135642177 0.980463170781473 0.75 30.3 30 3 poor circulation 0.0105163460485773 0.051955135642177 0.980463170781473 0.75 30.3 30 3 paternal imprinting 0.0105163460485773 0.051955135642177 0.980463170781473 0.75 30.3 30 3 impaired muscle relaxation 0.0105163460485773 0.051955135642177 0.980463170781473 0.75 30.3 30 3 decreased aggression towards mice 0.0105163460485773 0.051955135642177 0.980463170781473 0.75 30.3 30 3 small pancreas 0.0105163460485773 0.051955135642177 0.980463170781473 0.75 30.3 30 3 bowed radius 0.0105163460485773 0.051955135642177 0.980463170781473 0.75 30.3 30 3 abnormal wound healing 0.0105163460485773 0.051955135642177 0.980463170781473 0.75 30.3 30 3 abnormal amnion morphology 0.0105163460485773 0.051955135642177 0.980463170781473 0.75 30.3 30 3 loose skin 0.0105163460485773 0.051955135642177 0.980463170781473 0.75 30.3 30 3 impaired somite development 0.0105163460485773 0.051955135642177 0.980463170781473 0.75 30.3 30 3 decreased skeletal muscle weight 0.0105163460485773 0.051955135642177 0.980463170781473 0.75 30.3 30 3 increased heart left ventricle size 0.0105163460485773 0.051955135642177 0.980463170781473 0.75 30.3 30 3 decreased midbrain size 0.0105163460485773 0.051955135642177 0.980463170781473 0.75 30.3 30 3 pointed snout 0.0738208299597709 0.223257525258274 0.980463170781473 0.75 30.3 30 3 abnormal esophageal epithelium morphology 0.0738208299597709 0.223257525258274 0.980463170781473 0.75 30.3 30 3 enlarged pituitary gland 0.0738208299597709 0.223257525258274 0.980463170781473 0.75 30.3 30 3 abnormal hypoglossal nerve morphology 0.0738208299597709 0.223257525258274 0.980463170781473 0.75 30.3 30 3 abnormal vagus ganglion morphology 0.0738208299597709 0.223257525258274 0.980463170781473 0.75 30.3 30 3 dermal cysts 0.0738208299597709 0.223257525258274 0.980463170781473 0.75 30.3 30 3 abnormal hepatobiliary system morphology 0.0738208299597709 0.223257525258274 0.980463170781473 0.75 30.3 30 3 abnormal secondary sex determination 0.0738208299597709 0.223257525258274 0.980463170781473 0.75 30.3 30 3 abnormal thyroid physiology 0.0738208299597709 0.223257525258274 0.980463170781473 0.75 30.3 30 3 decreased corneal stroma thickness 0.0738208299597709 0.223257525258274 0.980463170781473 0.75 30.3 30 3 abnormal soft palate morphology 0.0738208299597709 0.223257525258274 0.980463170781473 0.75 30.3 30 3 abnormal cellular cholesterol metabolism 0.0738208299597709 0.223257525258274 0.980463170781473 0.75 30.3 30 3 decreased susceptibility to age related obesity 0.0738208299597709 0.223257525258274 0.980463170781473 0.75 30.3 30 3 liver cysts 0.0738208299597709 0.223257525258274 0.980463170781473 0.75 30.3 30 3 pulmonary interstitial fibrosis 0.0738208299597709 0.223257525258274 0.980463170781473 0.75 30.3 30 3 bowed fibula 0.0738208299597709 0.223257525258274 0.980463170781473 0.75 30.3 30 3 abnormal hair follicle melanocyte morphology 0.0738208299597709 0.223257525258274 0.980463170781473 0.75 30.3 30 3 absent interparietal bone 0.0738208299597709 0.223257525258274 0.980463170781473 0.75 30.3 30 3 abnormal NK cell morphology 0.0738208299597709 0.223257525258274 0.980463170781473 0.75 30.3 30 3 abnormal optic choroid morphology 0.0738208299597709 0.223257525258274 0.980463170781473 0.75 30.3 30 3 non-pigmented tail tip 0.0738208299597709 0.223257525258274 0.980463170781473 0.75 30.3 30 3 abnormal vertebral body development 0.0738208299597709 0.223257525258274 0.980463170781473 0.75 30.3 30 3 Sertoli cell hypoplasia 0.0738208299597709 0.223257525258274 0.980463170781473 0.75 30.3 30 3 abnormal mast cell differentiation 0.0738208299597709 0.223257525258274 0.980463170781473 0.75 30.3 30 3 enlarged inguinal lymph nodes 0.0738208299597709 0.223257525258274 0.980463170781473 0.75 30.3 30 3 abnormal sphingomyelin level 0.0738208299597709 0.223257525258274 0.980463170781473 0.75 30.3 30 3 skin fibrosis 0.0738208299597709 0.223257525258274 0.980463170781473 0.75 30.3 30 3 abnormal olfactory bulb glomerular layer morphology 0.0738208299597709 0.223257525258274 0.980463170781473 0.75 30.3 30 3 abnormal olfactory bulb mitral cell layer morphology 0.0738208299597709 0.223257525258274 0.980463170781473 0.75 30.3 30 3 decreased hippocampus pyramidal cell number 0.0738208299597709 0.223257525258274 0.980463170781473 0.75 30.3 30 3 increased caudal vertebrae number 0.0738208299597709 0.223257525258274 0.980463170781473 0.75 30.3 30 3 abnormal brain ependyma morphology 0.0738208299597709 0.223257525258274 0.980463170781473 0.75 30.3 30 3 decreased quadriceps weight 0.0738208299597709 0.223257525258274 0.980463170781473 0.75 30.3 30 3 pleural effusion 0.0738208299597709 0.223257525258274 0.980463170781473 0.75 30.3 30 3 increased heart right ventricle size 0.0738208299597709 0.223257525258274 0.980463170781473 0.75 30.3 30 3 lung situs inversus 0.0738208299597709 0.223257525258274 0.980463170781473 0.75 30.3 30 3 abnormal bronchiole epithelium morphology 0.0738208299597709 0.223257525258274 0.980463170781473 0.75 30.3 30 3 increased airway resistance 0.0738208299597709 0.223257525258274 0.980463170781473 0.75 30.3 30 3 abnormal maxillary prominence morphology 0.0738208299597709 0.223257525258274 0.980463170781473 0.75 30.3 30 3 decreased cranium length 0.0738208299597709 0.223257525258274 0.980463170781473 0.75 30.3 30 3 increased circulating ferritin level 0.0738208299597709 0.223257525258274 0.980463170781473 0.75 30.3 30 3 abnormal heart echocardiography feature 0.0738208299597709 0.223257525258274 0.980463170781473 0.75 30.3 30 3 prolonged PQ interval 0.0738208299597709 0.223257525258274 0.980463170781473 0.75 30.3 30 3 increased testis apoptosis 0.0738208299597709 0.223257525258274 0.980463170781473 0.75 30.3 30 3 abnormal umbilical vein topology 0.0738208299597709 0.223257525258274 0.980463170781473 0.75 30.3 30 3 oligodactyly 8.39365509143541e-06 0.000129283077646722 0.980463170781473 0.75 30.3 30 3 vertebral transformation 8.39365509143541e-06 0.000129283077646722 0.980463170781473 0.75 30.3 30 3 abnormal body weight 0.00167390671456087 0.0122465969190299 0.980463170781473 0.75 30.3 30 3 abnormal startle reflex 0.00167390671456087 0.0122465969190299 0.980463170781473 0.75 30.3 30 3 abnormal sensory capabilities/reflexes/nociception 0.00167390671456087 0.0122465969190299 0.980463170781473 0.75 30.3 30 3 increased hemangiosarcoma incidence 0.00167390671456087 0.0122465969190299 0.980463170781473 0.75 30.3 30 3 decreased fatty acid level 0.00167390671456087 0.0122465969190299 0.980463170781473 0.75 30.3 30 3 increased body temperature 0.00167390671456087 0.0122465969190299 0.980463170781473 0.75 30.3 30 3 abnormal inner cell mass apoptosis 0.00167390671456087 0.0122465969190299 0.980463170781473 0.75 30.3 30 3 abnormal truncus arteriosus septation 0.00167390671456087 0.0122465969190299 0.980463170781473 0.75 30.3 30 3 abnormal pericardium morphology 0.00416102521405234 0.0250139592149893 0.980463170781473 0.75 30.3 30 3 abnormal vascular regression 0.00416102521405234 0.0250139592149893 0.980463170781473 0.75 30.3 30 3 abnormal trachea morphology 0.00416102521405234 0.0250139592149893 0.980463170781473 0.75 30.3 30 3 abnormal optic stalk morphology 0.00416102521405234 0.0250139592149893 0.980463170781473 0.75 30.3 30 3 abnormal induced retinal neovascularization 0.00416102521405234 0.0250139592149893 0.980463170781473 0.75 30.3 30 3 abnormal sperm mitochondrial sheath morphology 0.00416102521405234 0.0250139592149893 0.980463170781473 0.75 30.3 30 3 abnormal neuron proliferation 0.00416102521405234 0.0250139592149893 0.980463170781473 0.75 30.3 30 3 increased skin tumor incidence 0.00416102521405234 0.0250139592149893 0.980463170781473 0.75 30.3 30 3 mesocardia 0.0272603967955752 0.110260548014623 0.980463170781473 0.75 30.3 30 3 abnormal superior cervical ganglion morphology 0.0272603967955752 0.110260548014623 0.980463170781473 0.75 30.3 30 3 abnormal pilomotor reflex 0.0272603967955752 0.110260548014623 0.980463170781473 0.75 30.3 30 3 abnormal AMPA-mediated synaptic currents 0.0272603967955752 0.110260548014623 0.980463170781473 0.75 30.3 30 3 abnormal aorta elastic fiber morphology 0.0272603967955752 0.110260548014623 0.980463170781473 0.75 30.3 30 3 loss of dopaminergic neurons 0.0272603967955752 0.110260548014623 0.980463170781473 0.75 30.3 30 3 delayed somite formation 0.0272603967955752 0.110260548014623 0.980463170781473 0.75 30.3 30 3 bowed ulna 0.0272603967955752 0.110260548014623 0.980463170781473 0.75 30.3 30 3 decreased cochlear nerve compound action potential 0.0272603967955752 0.110260548014623 0.980463170781473 0.75 30.3 30 3 abnormal fatty acid level 0.0272603967955752 0.110260548014623 0.980463170781473 0.75 30.3 30 3 reduced cerebellar foliation 0.0272603967955752 0.110260548014623 0.980463170781473 0.75 30.3 30 3 impaired behavioral response to cocaine 0.0272603967955752 0.110260548014623 0.980463170781473 0.75 30.3 30 3 increased fibrosarcoma incidence 0.0272603967955752 0.110260548014623 0.980463170781473 0.75 30.3 30 3 increased type II pneumocyte number 0.0272603967955752 0.110260548014623 0.980463170781473 0.75 30.3 30 3 embryonic lethality between implantation and placentation, incomplete penetrance 0.0272603967955752 0.110260548014623 0.980463170781473 0.75 30.3 30 3 abnormal colon goblet cell morphology 0.0272603967955752 0.110260548014623 0.980463170781473 0.75 30.3 30 3 reduced fertility 4.30521981258143e-14 3.32773679460857e-12 0.978111940156098 0.748201438848921 30.3 30 3 abnormal eye morphology 4.30521981258143e-14 3.32773679460857e-12 0.978111940156098 0.748201438848921 30.3 30 3 decreased circulating serum albumin level 2.10026335949868e-10 8.63538034174044e-09 0.977161947984229 0.747474747474748 30.3 30 3 abnormal placenta morphology 1.49542007063411e-08 4.40219813692585e-07 0.976326195377332 0.746835443037975 30.3 30 3 abnormal myocardium layer morphology 1.49542007063411e-08 4.40219813692585e-07 0.976326195377332 0.746835443037975 30.3 30 3 delayed bone ossification 3.51881804557854e-08 9.46276744689364e-07 0.976105556689111 0.746666666666667 30.3 30 3 impaired balance 1.55666726483811e-10 6.67622382980137e-09 0.974054914763294 0.745098039215686 30.3 30 3 distended abdomen 6.15517512713565e-06 9.94991508283603e-05 0.974054914763294 0.745098039215686 30.3 30 3 small lung 6.15517512713565e-06 9.94991508283603e-05 0.974054914763294 0.745098039215686 30.3 30 3 abnormal trophoblast layer morphology 6.15517512713565e-06 9.94991508283603e-05 0.974054914763294 0.745098039215686 30.3 30 3 abnormal behavior 3.91130580029431e-26 8.84488470748372e-24 0.973409478905347 0.744604316546763 30.3 30 3 increased oxygen consumption 4.70124272234682e-09 1.52867206167813e-07 0.972862681085493 0.744186046511628 30.3 30 3 kidney failure 3.5032750207837e-05 0.00046476781942397 0.972862681085493 0.744186046511628 30.3 30 3 abnormal heart ventricle morphology 2.59527447635116e-08 7.1730502888039e-07 0.972083143680777 0.743589743589744 30.3 30 3 embryonic lethality during organogenesis, incomplete penetrance 1.01021927549988e-21 1.62123899858449e-19 0.971937404079026 0.743478260869565 30.3 30 3 increased bone mineral content 4.91981539037171e-11 2.3763185987475e-09 0.971468095820175 0.743119266055046 30.3 30 3 abnormal embryonic epiblast morphology 0.000202371645166235 0.00212853897400004 0.97112542629784 0.742857142857143 30.3 30 3 decreased glycogen level 0.000202371645166235 0.00212853897400004 0.97112542629784 0.742857142857143 30.3 30 3 decreased total body fat amount 1.0533350257587e-30 4.03103211780735e-28 0.970678109196828 0.74251497005988 30.3 30 3 abnormal vascular development 3.39298483608267e-07 7.74316493555564e-06 0.970559502389741 0.742424242424242 30.3 30 3 prenatal lethality 8.01465702400281e-07 1.66832295792527e-05 0.969920556041887 0.741935483870968 30.3 30 3 abnormal eyelid morphology 0.000490164060687728 0.00451023373844712 0.969920556041887 0.741935483870968 30.3 30 3 inner cell mass degeneration 0.000490164060687728 0.00451023373844712 0.969920556041887 0.741935483870968 30.3 30 3 perinatal lethality, complete penetrance 5.14160609951567e-20 7.10541398474735e-18 0.969722572666496 0.741784037558685 30.3 30 3 decreased rib number 3.46469010603842e-09 1.16465089713116e-07 0.969446730660333 0.741573033707865 30.3 30 3 increased insulin sensitivity 7.09841322980046e-14 4.90480636364684e-12 0.969035861098705 0.741258741258741 30.3 30 3 decreased platelet aggregation 4.49544821657354e-06 7.55569421535586e-05 0.968358687191579 0.740740740740741 30.3 30 3 abnormal brain commissure morphology 0.00119551585269947 0.00945578913701088 0.968358687191579 0.740740740740741 30.3 30 3 abnormal eye muscle morphology 0.00119551585269947 0.00945578913701088 0.968358687191579 0.740740740740741 30.3 30 3 decreased heart weight 1.90857492076396e-08 5.39497740386403e-07 0.968358687191578 0.740740740740741 30.3 30 3 cleft palate 9.00956946680249e-13 5.746488217608e-11 0.967989084639215 0.740458015267176 30.3 30 3 decreased cardiac muscle contractility 1.98553264682384e-10 8.23168743162385e-09 0.967893130130429 0.740384615384615 30.3 30 3 kyphosis 2.24827178529263e-14 1.83363149702145e-12 0.967390328504387 0.74 30.3 30 3 increased B cell derived lymphoma incidence 1.06806854982518e-05 0.000161019425314554 0.967390328504387 0.74 30.3 30 3 abnormal nervous system physiology 2.6754430430196e-11 1.35819685092066e-09 0.966253559610727 0.739130434782609 30.3 30 3 perimembraneous ventricular septal defect 2.48477928346948e-07 5.88656044536222e-06 0.966253559610727 0.739130434782609 30.3 30 3 atrial septal defect 2.54421584431716e-05 0.000351596495152163 0.966253559610727 0.739130434782609 30.3 30 3 abnormal pulmonary artery morphology 0.00294242930302589 0.0191604525949657 0.966253559610727 0.739130434782609 30.3 30 3 abnormal innervation pattern to muscle 0.00294242930302589 0.0191604525949657 0.966253559610727 0.739130434782609 30.3 30 3 abnormal cranial nerve morphology 0.00294242930302589 0.0191604525949657 0.966253559610727 0.739130434782609 30.3 30 3 abnormal postnatal growth 0.00294242930302589 0.0191604525949657 0.966253559610727 0.739130434782609 30.3 30 3 abnormal cardiovascular development 0.00294242930302589 0.0191604525949657 0.966253559610727 0.739130434782609 30.3 30 3 abnormal chondrocyte physiology 0.00294242930302589 0.0191604525949657 0.966253559610727 0.739130434782609 30.3 30 3 abnormal palatal shelf fusion at midline 0.00294242930302589 0.0191604525949657 0.966253559610727 0.739130434782609 30.3 30 3 perinatal lethality, incomplete penetrance 8.91005386277099e-21 1.34325812022078e-18 0.966002062067882 0.738938053097345 30.3 30 3 infertility 1.46051652947704e-10 6.36949767449138e-09 0.965191158775531 0.738317757009346 30.3 30 3 abnormal craniofacial morphology 3.41431447638792e-10 1.36985600967983e-08 0.96459807093064 0.737864077669903 30.3 30 3 decreased hemoglobin content 2.09737578236442e-13 1.41006006990041e-11 0.964238011926933 0.737588652482269 30.3 30 3 abnormal retinal pigment epithelium morphology 3.28576970934615e-08 8.88407842608538e-07 0.964122117935115 0.7375 30.3 30 3 abnormal neuron morphology 7.98518371041215e-10 3.0795572836667e-08 0.963957056795253 0.737373737373737 30.3 30 3 abnormal facial morphology 3.27235355482426e-06 5.79357969226003e-05 0.963262062522149 0.736842105263158 30.3 30 3 irregular coat pigmentation 0.00733138339364467 0.0384742957630614 0.963262062522149 0.736842105263158 30.3 30 3 short vibrissae 0.00733138339364467 0.0384742957630614 0.963262062522149 0.736842105263158 30.3 30 3 decreased tumor incidence 0.00733138339364467 0.0384742957630614 0.963262062522149 0.736842105263158 30.3 30 3 decreased germ cell number 0.00733138339364467 0.0384742957630614 0.963262062522149 0.736842105263158 30.3 30 3 abnormal nasal septum morphology 0.00733138339364467 0.0384742957630614 0.963262062522149 0.736842105263158 30.3 30 3 increased susceptibility to ischemic brain injury 0.00733138339364467 0.0384742957630614 0.963262062522149 0.736842105263158 30.3 30 3 increased liver adenoma incidence 0.00733138339364467 0.0384742957630614 0.963262062522149 0.736842105263158 30.3 30 3 abnormal cochlear inner hair cell morphology 0.00733138339364467 0.0384742957630614 0.963262062522149 0.736842105263158 30.3 30 3 abnormal blastocyst morphology 0.00733138339364467 0.0384742957630614 0.963262062522149 0.736842105263158 30.3 30 3 decreased liver regeneration 0.00733138339364467 0.0384742957630614 0.963262062522149 0.736842105263158 30.3 30 3 Leydig cell hypoplasia 0.00733138339364467 0.0384742957630614 0.963262062522149 0.736842105263158 30.3 30 3 thin interventricular septum 0.00733138339364467 0.0384742957630614 0.963262062522149 0.736842105263158 30.3 30 3 abnormal digit morphology 1.81476297328746e-07 4.38274067577918e-06 0.962306445396631 0.736111111111111 30.3 30 3 embryonic lethality before implantation, complete penetrance 6.19259985629438e-12 3.42313158722939e-10 0.962161191593552 0.736 30.3 30 3 abnormal brown adipose tissue morphology 0.000351189233224084 0.00339255618502877 0.961238402726935 0.735294117647059 30.3 30 3 abnormal nervous system development 0.000351189233224084 0.00339255618502877 0.961238402726935 0.735294117647059 30.3 30 3 decreased osteoblast cell number 0.000351189233224084 0.00339255618502877 0.961238402726935 0.735294117647059 30.3 30 3 increased circulating LDL cholesterol level 1.84150471502788e-05 0.000261010995933439 0.960453718316545 0.73469387755102 30.3 30 3 abnormal gait 4.09592507377659e-27 9.70344154382788e-25 0.960367377637085 0.73462783171521 30.3 30 3 decreased circulating LDL cholesterol level 1.00662556691197e-06 2.03361490615698e-05 0.960036854723526 0.734375 30.3 30 3 trabecula carnea hypoplasia 4.38428755287318e-05 0.000559700050674403 0.958675100319663 0.733333333333333 30.3 30 3 abnormal myocardial trabeculae morphology 4.38428755287318e-05 0.000559700050674403 0.958675100319663 0.733333333333333 30.3 30 3 abnormal cell migration 4.38428755287318e-05 0.000559700050674403 0.958675100319663 0.733333333333333 30.3 30 3 lethality at weaning, complete penetrance 4.38428755287318e-05 0.000559700050674403 0.958675100319663 0.733333333333333 30.3 30 3 muscular ventricular septal defect 2.37545300347191e-06 4.31309441323823e-05 0.958675100319663 0.733333333333333 30.3 30 3 abnormal heart tube morphology 0.000850646196247233 0.00704153881252909 0.958675100319663 0.733333333333333 30.3 30 3 abnormal fontanelle morphology 0.0185896395565127 0.0802111507317007 0.958675100319663 0.733333333333333 30.3 30 3 absent incisors 0.0185896395565127 0.0802111507317007 0.958675100319663 0.733333333333333 30.3 30 3 decreased chondrocyte number 0.0185896395565127 0.0802111507317007 0.958675100319663 0.733333333333333 30.3 30 3 abnormal enteric neuron morphology 0.0185896395565127 0.0802111507317007 0.958675100319663 0.733333333333333 30.3 30 3 placental labyrinth hypoplasia 0.0185896395565127 0.0802111507317007 0.958675100319663 0.733333333333333 30.3 30 3 abnormal trophectoderm morphology 0.0185896395565127 0.0802111507317007 0.958675100319663 0.733333333333333 30.3 30 3 abnormal olfactory nerve morphology 0.0185896395565127 0.0802111507317007 0.958675100319663 0.733333333333333 30.3 30 3 abnormal dendritic cell morphology 0.0185896395565127 0.0802111507317007 0.958675100319663 0.733333333333333 30.3 30 3 bicuspid aortic valve 0.0185896395565127 0.0802111507317007 0.958675100319663 0.733333333333333 30.3 30 3 decreased brown adipose tissue mass 0.0185896395565127 0.0802111507317007 0.958675100319663 0.733333333333333 30.3 30 3 abnormal coat/hair pigmentation 1.34064202009726e-10 5.90238411502998e-09 0.957118809572391 0.732142857142857 30.3 30 3 microphthalmia 6.08072319755162e-14 4.32165684397419e-12 0.956966232048148 0.73202614379085 30.3 30 3 rib fusion 7.306816721861e-07 1.53381490258475e-05 0.956073539667506 0.73134328358209 30.3 30 3 decreased kidney weight 1.32930301617867e-05 0.000195082079807932 0.955323089479384 0.730769230769231 30.3 30 3 thick skin 0.00207480812817053 0.0146413765073027 0.955323089479384 0.730769230769231 30.3 30 3 heart inflammation 0.00207480812817053 0.0146413765073027 0.955323089479384 0.730769230769231 30.3 30 3 abnormal Mullerian duct morphology 0.00207480812817053 0.0146413765073027 0.955323089479384 0.730769230769231 30.3 30 3 decreased susceptibility to hepatic steatosis 1.72038607692539e-06 3.26375163555442e-05 0.95452499166027 0.73015873015873 30.3 30 3 increased circulating phosphate level 0.000250889548912079 0.00254729695068897 0.953964166165758 0.72972972972973 30.3 30 3 impaired skeletal muscle contractility 0.000250889548912079 0.00254729695068897 0.953964166165758 0.72972972972973 30.3 30 3 increased erythroid progenitor cell number 0.000250889548912079 0.00254729695068897 0.953964166165758 0.72972972972973 30.3 30 3 small heart 3.15382335878481e-05 0.000422918361454297 0.95322808270421 0.729166666666667 30.3 30 3 impaired coordination 5.65341498333484e-29 1.65445526718181e-26 0.952126084920737 0.728323699421965 30.3 30 3 respiratory distress 3.21459115086227e-15 2.78623250592642e-13 0.952126084920737 0.728323699421965 30.3 30 3 seizures 1.66036257701113e-10 7.06008873558149e-09 0.951794657015933 0.728070175438597 30.3 30 3 abnormal learning/memory/conditioning 9.57483440003616e-06 0.000145672174740611 0.950752165606277 0.727272727272727 30.3 30 3 hypertension 7.5003563668866e-05 0.000884224476901916 0.950752165606277 0.727272727272727 30.3 30 3 abnormal amino acid level 7.5003563668866e-05 0.000884224476901916 0.950752165606277 0.727272727272727 30.3 30 3 decreased blood urea nitrogen level 7.5003563668866e-05 0.000884224476901916 0.950752165606277 0.727272727272727 30.3 30 3 intracerebral hemorrhage 0.00510663584065125 0.0298537171647943 0.950752165606277 0.727272727272727 30.3 30 3 abnormal chorion morphology 0.00510663584065125 0.0298537171647943 0.950752165606277 0.727272727272727 30.3 30 3 increased myocardial infarction size 0.00510663584065125 0.0298537171647943 0.950752165606277 0.727272727272727 30.3 30 3 aphakia 0.00510663584065125 0.0298537171647943 0.950752165606277 0.727272727272727 30.3 30 3 abnormal lysosome physiology 0.00510663584065125 0.0298537171647943 0.950752165606277 0.727272727272727 30.3 30 3 abnormal cochlear sensory epithelium morphology 0.00510663584065125 0.0298537171647943 0.950752165606277 0.727272727272727 30.3 30 3 failure of palatal shelf elevation 0.00510663584065125 0.0298537171647943 0.950752165606277 0.727272727272727 30.3 30 3 abnormal cerebral cortex pyramidal cell morphology 0.00510663584065125 0.0298537171647943 0.950752165606277 0.727272727272727 30.3 30 3 absent semicircular canals 0.0484261200049242 0.164900716649211 0.950752165606277 0.727272727272727 30.3 30 3 abnormal sebaceous gland morphology 0.0484261200049242 0.164900716649211 0.950752165606277 0.727272727272727 30.3 30 3 abnormal enteric ganglia morphology 0.0484261200049242 0.164900716649211 0.950752165606277 0.727272727272727 30.3 30 3 abnormal food preference 0.0484261200049242 0.164900716649211 0.950752165606277 0.727272727272727 30.3 30 3 abnormal hemoglobin 0.0484261200049242 0.164900716649211 0.950752165606277 0.727272727272727 30.3 30 3 abnormal larynx morphology 0.0484261200049242 0.164900716649211 0.950752165606277 0.727272727272727 30.3 30 3 fatigue 0.0484261200049242 0.164900716649211 0.950752165606277 0.727272727272727 30.3 30 3 decreased post-tetanic potentiation 0.0484261200049242 0.164900716649211 0.950752165606277 0.727272727272727 30.3 30 3 fused joints 0.0484261200049242 0.164900716649211 0.950752165606277 0.727272727272727 30.3 30 3 abnormal frequency of paradoxical sleep 0.0484261200049242 0.164900716649211 0.950752165606277 0.727272727272727 30.3 30 3 impaired luteinization 0.0484261200049242 0.164900716649211 0.950752165606277 0.727272727272727 30.3 30 3 abnormal nerve fiber response 0.0484261200049242 0.164900716649211 0.950752165606277 0.727272727272727 30.3 30 3 abnormal coronal suture morphology 0.0484261200049242 0.164900716649211 0.950752165606277 0.727272727272727 30.3 30 3 cyclopia 0.0484261200049242 0.164900716649211 0.950752165606277 0.727272727272727 30.3 30 3 increased glycogen level 0.0484261200049242 0.164900716649211 0.950752165606277 0.727272727272727 30.3 30 3 abnormal platelet aggregation 0.0484261200049242 0.164900716649211 0.950752165606277 0.727272727272727 30.3 30 3 abnormal palatal shelf elevation 0.0484261200049242 0.164900716649211 0.950752165606277 0.727272727272727 30.3 30 3 common atrioventricular valve 0.0484261200049242 0.164900716649211 0.950752165606277 0.727272727272727 30.3 30 3 abnormal extraembryonic ectoderm morphology 0.0484261200049242 0.164900716649211 0.950752165606277 0.727272727272727 30.3 30 3 decreased embryonic cilium length 0.0484261200049242 0.164900716649211 0.950752165606277 0.727272727272727 30.3 30 3 abnormal phrenic nerve innervation pattern to diaphragm 0.0484261200049242 0.164900716649211 0.950752165606277 0.727272727272727 30.3 30 3 hypolactation 0.0484261200049242 0.164900716649211 0.950752165606277 0.727272727272727 30.3 30 3 reduced sympathetic cervical ganglion size 0.0484261200049242 0.164900716649211 0.950752165606277 0.727272727272727 30.3 30 3 enlarged pericardium 0.000603822449707838 0.0053262707221569 0.950752165606277 0.727272727272727 30.3 30 3 dextrocardia 0.000603822449707838 0.0053262707221569 0.950752165606277 0.727272727272727 30.3 30 3 decreased brown adipose tissue amount 0.000603822449707838 0.0053262707221569 0.950752165606277 0.727272727272727 30.3 30 3 increased cardiomyocyte apoptosis 0.000603822449707838 0.0053262707221569 0.950752165606277 0.727272727272727 30.3 30 3 myeloid hyperplasia 0.000603822449707838 0.0053262707221569 0.950752165606277 0.727272727272727 30.3 30 3 prenatal lethality, incomplete penetrance 2.09662756244485e-25 4.34613421798464e-23 0.950361231327656 0.726973684210526 30.3 30 3 prenatal lethality, complete penetrance 2.65447727607432e-23 4.7164373030249e-21 0.949897172651595 0.726618705035971 30.3 30 3 cleft secondary palate 1.13585266888615e-08 3.42476789558098e-07 0.945694973236031 0.723404255319149 30.3 30 3 abnormal innervation 5.36364753896754e-05 0.00066931039151543 0.945694973236031 0.723404255319149 30.3 30 3 short tail 8.54032752754704e-08 2.1567578400785e-06 0.945024742921902 0.72289156626506 30.3 30 3 postnatal lethality, complete penetrance 5.32712474298585e-31 2.20853713302955e-28 0.944902330390435 0.72279792746114 30.3 30 3 postnatal growth retardation 3.02704529257056e-48 1.88244379131732e-45 0.944149720011789 0.722222222222222 30.3 30 3 abnormal chondrocyte morphology 1.62275001828771e-05 0.00023198796956843 0.944149720011789 0.722222222222222 30.3 30 3 abnormal apoptosis 1.62275001828771e-05 0.00023198796956843 0.944149720011789 0.722222222222222 30.3 30 3 thin ventricular wall 2.64554405718363e-08 7.23163828818054e-07 0.944149720011789 0.722222222222222 30.3 30 3 oxidative stress 2.64554405718363e-08 7.23163828818054e-07 0.944149720011789 0.722222222222222 30.3 30 3 abnormal limb bone morphology 0.00042796714669463 0.00399462768256244 0.944149720011789 0.722222222222222 30.3 30 3 cortical renal glomerulopathies 0.0127230709616541 0.0612159362033162 0.944149720011789 0.722222222222222 30.3 30 3 eye inflammation 0.0127230709616541 0.0612159362033162 0.944149720011789 0.722222222222222 30.3 30 3 abnormal thymus cortex morphology 0.0127230709616541 0.0612159362033162 0.944149720011789 0.722222222222222 30.3 30 3 abnormal body wall morphology 0.0127230709616541 0.0612159362033162 0.944149720011789 0.722222222222222 30.3 30 3 decreased activity of thyroid 0.0127230709616541 0.0612159362033162 0.944149720011789 0.722222222222222 30.3 30 3 abnormal anterior eye segment morphology 0.0127230709616541 0.0612159362033162 0.944149720011789 0.722222222222222 30.3 30 3 darkened coat color 0.0127230709616541 0.0612159362033162 0.944149720011789 0.722222222222222 30.3 30 3 decreased tumor latency 0.0127230709616541 0.0612159362033162 0.944149720011789 0.722222222222222 30.3 30 3 atrioventricular block 0.0127230709616541 0.0612159362033162 0.944149720011789 0.722222222222222 30.3 30 3 abnormal placenta labyrinth morphology 1.99327854970838e-07 4.77961134628183e-06 0.943230392144202 0.721518987341772 30.3 30 3 abnormal vasculogenesis 0.000127334490316419 0.00140463212710462 0.942460722301571 0.720930232558139 30.3 30 3 abnormal axon guidance 0.000127334490316419 0.00140463212710462 0.942460722301571 0.720930232558139 30.3 30 3 delayed endochondral bone ossification 0.000127334490316419 0.00140463212710462 0.942460722301571 0.720930232558139 30.3 30 3 abnormal thyroid gland morphology 0.00355805566365793 0.0219892259958984 0.941244643950214 0.72 30.3 30 3 abnormal nest building behavior 0.00355805566365793 0.0219892259958984 0.941244643950214 0.72 30.3 30 3 abnormal egg cylinder morphology 0.00355805566365793 0.0219892259958984 0.941244643950214 0.72 30.3 30 3 abnormal keratinocyte physiology 0.00355805566365793 0.0219892259958984 0.941244643950214 0.72 30.3 30 3 diaphragmatic hernia 0.00355805566365793 0.0219892259958984 0.941244643950214 0.72 30.3 30 3 increased cellular sensitivity to ionizing radiation 0.00355805566365793 0.0219892259958984 0.941244643950214 0.72 30.3 30 3 abnormal preimplantation embryo development 0.00355805566365793 0.0219892259958984 0.941244643950214 0.72 30.3 30 3 decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 0.00355805566365793 0.0219892259958984 0.941244643950214 0.72 30.3 30 3 increased hepatocellular carcinoma incidence 1.16157102071504e-05 0.000171478214482413 0.940327251509717 0.719298245614035 30.3 30 3 decreased hematocrit 2.36885037987433e-12 1.43719885852132e-10 0.940170163763057 0.719178082191781 30.3 30 3 hypoactivity 1.64832619626784e-29 5.85744487602321e-27 0.939718901084984 0.718832891246684 30.3 30 3 decreased caudal vertebrae number 3.54444071362631e-06 6.18722545624242e-05 0.939610538665578 0.71875 30.3 30 3 failure of primitive streak formation 0.00102799843880127 0.00827555377513967 0.939610538665578 0.71875 30.3 30 3 neonatal lethality 0.00102799843880127 0.00827555377513967 0.939610538665578 0.71875 30.3 30 3 abnormal diaphragm morphology 0.00102799843880127 0.00827555377513967 0.939610538665578 0.71875 30.3 30 3 bradykinesia 0.00102799843880127 0.00827555377513967 0.939610538665578 0.71875 30.3 30 3 increased fatty acid level 0.00102799843880127 0.00827555377513967 0.939610538665578 0.71875 30.3 30 3 abnormal skeletal muscle fiber morphology 1.08684414691874e-06 2.17150587587179e-05 0.939035149480848 0.71830985915493 30.3 30 3 decreased liver weight 1.08684414691874e-06 2.17150587587179e-05 0.939035149480848 0.71830985915493 30.3 30 3 abnormal heart looping 0.000303036426771355 0.00299722907194332 0.938563035277991 0.717948717948718 30.3 30 3 increased vascular permeability 0.000303036426771355 0.00299722907194332 0.938563035277991 0.717948717948718 30.3 30 3 increased tumor incidence 1.29548851104994e-10 5.754513698637e-09 0.93829271182313 0.717741935483871 30.3 30 3 cardiac fibrosis 1.03320787494728e-07 2.5960652413448e-06 0.938168681061488 0.717647058823529 30.3 30 3 extramedullary hematopoiesis 3.08618075359792e-09 1.05162666090066e-07 0.937298125526943 0.716981132075472 30.3 30 3 increased circulating bilirubin level 2.73243493355944e-05 0.000371417043564433 0.937298125526943 0.716981132075472 30.3 30 3 intracranial hemorrhage 8.3058641803619e-06 0.000128727957312462 0.936887029857852 0.716666666666667 30.3 30 3 abnormal skeleton development 2.40309905489518e-07 5.72029559717872e-06 0.936080064285192 0.716049382716049 30.3 30 3 reduced long term potentiation 1.6006628142737e-09 5.72899100792205e-08 0.933774448363308 0.714285714285714 30.3 30 3 enhanced long term potentiation 1.94760493886264e-05 0.000272939001995539 0.933774448363308 0.714285714285714 30.3 30 3 rib bifurcation 0.00248106933040937 0.0169086574229954 0.933774448363308 0.714285714285714 30.3 30 3 abnormal circulating cholesterol level 0.00248106933040937 0.0169086574229954 0.933774448363308 0.714285714285714 30.3 30 3 abnormal retinal inner nuclear layer morphology 0.00248106933040937 0.0169086574229954 0.933774448363308 0.714285714285714 30.3 30 3 premature aging 0.00248106933040937 0.0169086574229954 0.933774448363308 0.714285714285714 30.3 30 3 abnormal mitotic spindle morphology 0.00248106933040937 0.0169086574229954 0.933774448363308 0.714285714285714 30.3 30 3 translucent skin 0.032252973140153 0.125260375778502 0.933774448363308 0.714285714285714 30.3 30 3 increased aggression towards males 0.032252973140153 0.125260375778502 0.933774448363308 0.714285714285714 30.3 30 3 abnormal ventral body wall morphology 0.032252973140153 0.125260375778502 0.933774448363308 0.714285714285714 30.3 30 3 failure of zygotic cell division 0.032252973140153 0.125260375778502 0.933774448363308 0.714285714285714 30.3 30 3 abnormal voluntary movement 0.032252973140153 0.125260375778502 0.933774448363308 0.714285714285714 30.3 30 3 abnormal pancreas development 0.032252973140153 0.125260375778502 0.933774448363308 0.714285714285714 30.3 30 3 abnormal maternal decidual layer morphology 0.032252973140153 0.125260375778502 0.933774448363308 0.714285714285714 30.3 30 3 increased pulmonary respiratory rate 0.032252973140153 0.125260375778502 0.933774448363308 0.714285714285714 30.3 30 3 sternebra fusion 0.032252973140153 0.125260375778502 0.933774448363308 0.714285714285714 30.3 30 3 pulmonary alveolar hemorrhage 0.032252973140153 0.125260375778502 0.933774448363308 0.714285714285714 30.3 30 3 abnormal renal tubule epithelial cell primary cilium morphology 0.032252973140153 0.125260375778502 0.933774448363308 0.714285714285714 30.3 30 3 multiple persisting craniopharyngeal ducts 0.032252973140153 0.125260375778502 0.933774448363308 0.714285714285714 30.3 30 3 abnormal vitelline vein topology 0.032252973140153 0.125260375778502 0.933774448363308 0.714285714285714 30.3 30 3 decreased response to antigen 0.032252973140153 0.125260375778502 0.933774448363308 0.714285714285714 30.3 30 3 cochlear degeneration 0.132234684799375 0.326809516580671 0.933774448363308 0.714285714285714 30.3 30 3 growth retardation of molars 0.132234684799375 0.326809516580671 0.933774448363308 0.714285714285714 30.3 30 3 maxilla hypoplasia 0.132234684799375 0.326809516580671 0.933774448363308 0.714285714285714 30.3 30 3 small L4 dorsal root ganglion 0.132234684799375 0.326809516580671 0.933774448363308 0.714285714285714 30.3 30 3 prostate gland epithelial hyperplasia 0.132234684799375 0.326809516580671 0.933774448363308 0.714285714285714 30.3 30 3 retina hyperplasia 0.132234684799375 0.326809516580671 0.933774448363308 0.714285714285714 30.3 30 3 excessive tearing 0.132234684799375 0.326809516580671 0.933774448363308 0.714285714285714 30.3 30 3 abnormal circulating free fatty acids level 0.132234684799375 0.326809516580671 0.933774448363308 0.714285714285714 30.3 30 3 absent amniotic folds 0.132234684799375 0.326809516580671 0.933774448363308 0.714285714285714 30.3 30 3 abnormal tumor incidence 0.132234684799375 0.326809516580671 0.933774448363308 0.714285714285714 30.3 30 3 abnormal brain ventricular system morphology 0.132234684799375 0.326809516580671 0.933774448363308 0.714285714285714 30.3 30 3 abnormal adrenal gland physiology 0.132234684799375 0.326809516580671 0.933774448363308 0.714285714285714 30.3 30 3 abnormal inhibitory postsynaptic potential 0.132234684799375 0.326809516580671 0.933774448363308 0.714285714285714 30.3 30 3 decreased urine calcium level 0.132234684799375 0.326809516580671 0.933774448363308 0.714285714285714 30.3 30 3 decreased mortality induced by ionizing radiation 0.132234684799375 0.326809516580671 0.933774448363308 0.714285714285714 30.3 30 3 absent tunnel of Corti 0.132234684799375 0.326809516580671 0.933774448363308 0.714285714285714 30.3 30 3 decreased cholesterol efflux 0.132234684799375 0.326809516580671 0.933774448363308 0.714285714285714 30.3 30 3 abnormal sinus venosus morphology 0.132234684799375 0.326809516580671 0.933774448363308 0.714285714285714 30.3 30 3 increased muscle weight 0.132234684799375 0.326809516580671 0.933774448363308 0.714285714285714 30.3 30 3 abnormal prostate gland physiology 0.132234684799375 0.326809516580671 0.933774448363308 0.714285714285714 30.3 30 3 abnormal Purkinje cell innervation 0.132234684799375 0.326809516580671 0.933774448363308 0.714285714285714 30.3 30 3 increased ectoderm apoptosis 0.132234684799375 0.326809516580671 0.933774448363308 0.714285714285714 30.3 30 3 absent vestibular saccule 0.132234684799375 0.326809516580671 0.933774448363308 0.714285714285714 30.3 30 3 absent ulna 0.132234684799375 0.326809516580671 0.933774448363308 0.714285714285714 30.3 30 3 abnormal cochlear nerve compound action potential 0.132234684799375 0.326809516580671 0.933774448363308 0.714285714285714 30.3 30 3 abnormal ciliary body morphology 0.132234684799375 0.326809516580671 0.933774448363308 0.714285714285714 30.3 30 3 abnormal talus morphology 0.132234684799375 0.326809516580671 0.933774448363308 0.714285714285714 30.3 30 3 decreased adrenocorticotropin level 0.132234684799375 0.326809516580671 0.933774448363308 0.714285714285714 30.3 30 3 atherosclerotic lesions 0.132234684799375 0.326809516580671 0.933774448363308 0.714285714285714 30.3 30 3 abnormal thyroid hormone level 0.132234684799375 0.326809516580671 0.933774448363308 0.714285714285714 30.3 30 3 retinal pigment epithelium atrophy 0.132234684799375 0.326809516580671 0.933774448363308 0.714285714285714 30.3 30 3 abnormal renal filtration rate 0.132234684799375 0.326809516580671 0.933774448363308 0.714285714285714 30.3 30 3 abnormal spinal cord central canal morphology 0.132234684799375 0.326809516580671 0.933774448363308 0.714285714285714 30.3 30 3 focal dorsal hair loss 0.132234684799375 0.326809516580671 0.933774448363308 0.714285714285714 30.3 30 3 increased quadriceps weight 0.132234684799375 0.326809516580671 0.933774448363308 0.714285714285714 30.3 30 3 decreased skeletal muscle glycogen level 0.132234684799375 0.326809516580671 0.933774448363308 0.714285714285714 30.3 30 3 coronary fistula 0.132234684799375 0.326809516580671 0.933774448363308 0.714285714285714 30.3 30 3 abnormal conotruncal ridge morphology 0.132234684799375 0.326809516580671 0.933774448363308 0.714285714285714 30.3 30 3 abnormal aortic valve cusp morphology 0.132234684799375 0.326809516580671 0.933774448363308 0.714285714285714 30.3 30 3 thick pulmonary valve 0.132234684799375 0.326809516580671 0.933774448363308 0.714285714285714 30.3 30 3 thick mitral valve cusps 0.132234684799375 0.326809516580671 0.933774448363308 0.714285714285714 30.3 30 3 altered tumor pathology 0.132234684799375 0.326809516580671 0.933774448363308 0.714285714285714 30.3 30 3 abnormal impulsive behavior control 0.132234684799375 0.326809516580671 0.933774448363308 0.714285714285714 30.3 30 3 abnormal tricarboxylic acid cycle 0.132234684799375 0.326809516580671 0.933774448363308 0.714285714285714 30.3 30 3 increased compact bone volume 0.132234684799375 0.326809516580671 0.933774448363308 0.714285714285714 30.3 30 3 small lung lobe 0.132234684799375 0.326809516580671 0.933774448363308 0.714285714285714 30.3 30 3 abnormal brain ependyma motile cilium physiology 0.132234684799375 0.326809516580671 0.933774448363308 0.714285714285714 30.3 30 3 absent heart tube 0.132234684799375 0.326809516580671 0.933774448363308 0.714285714285714 30.3 30 3 decreased CD8-positive, naive alpha-beta T cell number 0.132234684799375 0.326809516580671 0.933774448363308 0.714285714285714 30.3 30 3 decreased areal bone mineral density 0.132234684799375 0.326809516580671 0.933774448363308 0.714285714285714 30.3 30 3 decreased femur compact bone thickness 0.132234684799375 0.326809516580671 0.933774448363308 0.714285714285714 30.3 30 3 abnormal Mullerian duct topology 0.132234684799375 0.326809516580671 0.933774448363308 0.714285714285714 30.3 30 3 abnormal tectorial membrane striated-sheet matrix morphology 0.132234684799375 0.326809516580671 0.933774448363308 0.714285714285714 30.3 30 3 abnormal heart morphology 4.29327143119996e-18 5.08548223100471e-16 0.933774448363308 0.714285714285714 30.3 30 3 abnormal cartilage morphology 0.000214448692954264 0.0022394087023074 0.933774448363308 0.714285714285714 30.3 30 3 abnormal pancreas morphology 0.000214448692954264 0.0022394087023074 0.933774448363308 0.714285714285714 30.3 30 3 abnormal spleen white pulp morphology 0.000214448692954264 0.0022394087023074 0.933774448363308 0.714285714285714 30.3 30 3 thick pulmonary interalveolar septum 0.000723233203368704 0.00611919249448861 0.933774448363308 0.714285714285714 30.3 30 3 abnormal artery morphology 0.000723233203368704 0.00611919249448861 0.933774448363308 0.714285714285714 30.3 30 3 decreased triglyceride level 0.000723233203368704 0.00611919249448861 0.933774448363308 0.714285714285714 30.3 30 3 decreased bone volume 0.000723233203368704 0.00611919249448861 0.933774448363308 0.714285714285714 30.3 30 3 abnormal salivary gland morphology 0.00873957949476967 0.044594264601517 0.933774448363308 0.714285714285714 30.3 30 3 abnormal clavicle morphology 0.00873957949476967 0.044594264601517 0.933774448363308 0.714285714285714 30.3 30 3 vascular ring 0.00873957949476967 0.044594264601517 0.933774448363308 0.714285714285714 30.3 30 3 absent segment of posterior cerebral artery 0.00873957949476967 0.044594264601517 0.933774448363308 0.714285714285714 30.3 30 3 polydactyly 1.65506382322056e-08 4.75950434712269e-07 0.933774448363308 0.714285714285714 30.3 30 3 increased T cell derived lymphoma incidence 6.43461996817711e-05 0.000780786203455638 0.933774448363308 0.714285714285714 30.3 30 3 cyanosis 3.24827106218557e-15 2.78623250592642e-13 0.932801766646263 0.713541666666667 30.3 30 3 abnormal social investigation 4.00358199448378e-07 8.89188411721285e-06 0.931440012242399 0.7125 30.3 30 3 decreased bone marrow cell number 1.29990320743169e-06 2.53608566940104e-05 0.931216162203408 0.712328767123288 30.3 30 3 abnormal thoracic vertebrae morphology 1.38729781770911e-05 0.000202399021791872 0.930609111250212 0.711864406779661 30.3 30 3 eyelids open at birth 4.56991970140449e-05 0.000578562733529381 0.930183008177295 0.711538461538462 30.3 30 3 postnatal lethality, incomplete penetrance 1.4716301087155e-41 7.32135979085963e-39 0.929828922525153 0.711267605633803 30.3 30 3 small placenta 0.000151706796013811 0.00166242579332315 0.929624339703915 0.711111111111111 30.3 30 3 abnormal metabolism 0.000151706796013811 0.00166242579332315 0.929624339703915 0.711111111111111 30.3 30 3 anemia 2.75163117720013e-16 2.79374798093279e-14 0.92934897704405 0.710900473933649 30.3 30 3 decreased hair follicle number 0.000508864080304427 0.00464513541195325 0.928859846003501 0.710526315789474 30.3 30 3 abnormal reproductive system physiology 0.000508864080304427 0.00464513541195325 0.928859846003501 0.710526315789474 30.3 30 3 osteopetrosis 0.00173182474983713 0.0124200277558198 0.927750097083545 0.709677419354839 30.3 30 3 abnormal cranial ganglia morphology 0.00173182474983713 0.0124200277558198 0.927750097083545 0.709677419354839 30.3 30 3 abnormal nose morphology 0.00173182474983713 0.0124200277558198 0.927750097083545 0.709677419354839 30.3 30 3 abnormal capillary morphology 0.00173182474983713 0.0124200277558198 0.927750097083545 0.709677419354839 30.3 30 3 pale kidney 0.00173182474983713 0.0124200277558198 0.927750097083545 0.709677419354839 30.3 30 3 decreased neuronal precursor cell number 0.00173182474983713 0.0124200277558198 0.927750097083545 0.709677419354839 30.3 30 3 preaxial polydactyly 0.00173182474983713 0.0124200277558198 0.927750097083545 0.709677419354839 30.3 30 3 abnormal mitochondrial ATP synthesis coupled electron transport 0.00173182474983713 0.0124200277558198 0.927750097083545 0.709677419354839 30.3 30 3 decreased body size 3.27168085357334e-57 2.32523032093248e-54 0.927221645216899 0.709273182957393 30.3 30 3 decreased body weight 8.06049775749629e-89 4.0100976343544e-85 0.927136956323245 0.709208400646204 30.3 30 3 abnormal neuromuscular synapse morphology 2.15597393294151e-06 3.95792262597195e-05 0.925992994626947 0.708333333333333 30.3 30 3 curly tail 0.000107303634051257 0.00121602637677678 0.925992994626947 0.708333333333333 30.3 30 3 abnormal digestive system morphology 0.0060231270178695 0.0337859545231954 0.925992994626947 0.708333333333333 30.3 30 3 decreased metastatic potential 0.0060231270178695 0.0337859545231954 0.925992994626947 0.708333333333333 30.3 30 3 curly vibrissae 0.0060231270178695 0.0337859545231954 0.925992994626947 0.708333333333333 30.3 30 3 hemolytic anemia 0.0060231270178695 0.0337859545231954 0.925992994626947 0.708333333333333 30.3 30 3 abnormal primitive streak formation 0.0060231270178695 0.0337859545231954 0.925992994626947 0.708333333333333 30.3 30 3 abnormal retinal ganglion layer morphology 0.0060231270178695 0.0337859545231954 0.925992994626947 0.708333333333333 30.3 30 3 abnormal muscle physiology 1.46639402338782e-07 3.57613248350707e-06 0.925380970175772 0.707865168539326 30.3 30 3 premature death 7.92542986336803e-61 7.88580271405119e-58 0.924664453745129 0.707317073170732 30.3 30 3 sparse hair 4.74072491030394e-07 1.04822695238943e-05 0.924664453745129 0.707317073170732 30.3 30 3 arrested B cell differentiation 0.000358123774915332 0.00344616205068429 0.924664453745129 0.707317073170732 30.3 30 3 increased tumor growth/size 0.000358123774915332 0.00344616205068429 0.924664453745129 0.707317073170732 30.3 30 3 decreased bone mineral content 1.23238659153442e-15 1.15681571563844e-13 0.923897987851773 0.706730769230769 30.3 30 3 abnormal neurocranium morphology 1.53702951217661e-06 2.94104685503024e-05 0.923814187580766 0.706666666666667 30.3 30 3 spleen hyperplasia 1.53702951217661e-06 2.94104685503024e-05 0.923814187580766 0.706666666666667 30.3 30 3 abnormal adipose tissue morphology 0.0217101955914427 0.0910693280501073 0.922788866617857 0.705882352941177 30.3 30 3 abnormal vagus nerve morphology 0.0217101955914427 0.0910693280501073 0.922788866617857 0.705882352941177 30.3 30 3 hyperlipidemia 0.0217101955914427 0.0910693280501073 0.922788866617857 0.705882352941177 30.3 30 3 abnormal duodenum morphology 0.0217101955914427 0.0910693280501073 0.922788866617857 0.705882352941177 30.3 30 3 aminoaciduria 0.0217101955914427 0.0910693280501073 0.922788866617857 0.705882352941177 30.3 30 3 abnormal testis development 0.0217101955914427 0.0910693280501073 0.922788866617857 0.705882352941177 30.3 30 3 abnormal embryonic-extraembryonic boundary morphology 0.0217101955914427 0.0910693280501073 0.922788866617857 0.705882352941177 30.3 30 3 increased regulatory T cell number 0.0217101955914427 0.0910693280501073 0.922788866617857 0.705882352941177 30.3 30 3 abnormal cell cytoskeleton morphology 0.0217101955914427 0.0910693280501073 0.922788866617857 0.705882352941177 30.3 30 3 increased lung adenocarcinoma incidence 7.58932683475012e-05 0.000892598132455836 0.922788866617857 0.705882352941177 30.3 30 3 decreased birth weight 7.4902472821323e-08 1.90122348105144e-06 0.921979402699771 0.705263157894737 30.3 30 3 increased rib number 1.09541593313098e-06 2.17987770693066e-05 0.921802981076599 0.705128205128205 30.3 30 3 abnormal long bone morphology 1.63399080328352e-05 0.000232925623104169 0.921528226089691 0.704918032786885 30.3 30 3 neonatal lethality, incomplete penetrance 8.48179751699375e-19 1.0549235661761e-16 0.920126975656459 0.703846153846154 30.3 30 3 increased cell proliferation 5.36793660732978e-05 0.00066931039151543 0.919940752832 0.703703703703704 30.3 30 3 abnormal long bone epiphyseal plate proliferative zone 5.36793660732978e-05 0.00066931039151543 0.919940752832 0.703703703703704 30.3 30 3 rectal prolapse 0.0041631272824143 0.0250139592149893 0.919940752832 0.703703703703704 30.3 30 3 abnormal trigeminal nerve morphology 0.0041631272824143 0.0250139592149893 0.919940752832 0.703703703703704 30.3 30 3 decreased susceptibility to pharmacologically induced seizures 0.0041631272824143 0.0250139592149893 0.919940752832 0.703703703703704 30.3 30 3 abnormal bone trabecula morphology 0.0041631272824143 0.0250139592149893 0.919940752832 0.703703703703704 30.3 30 3 limb grasping 1.48919559462942e-13 1.01489699770978e-11 0.919408687619257 0.703296703296703 30.3 30 3 abnormal intestine morphology 2.52942217386802e-06 4.54291527617091e-05 0.91863216001147 0.702702702702703 30.3 30 3 kidney cysts 2.52942217386802e-06 4.54291527617091e-05 0.91863216001147 0.702702702702703 30.3 30 3 abnormal breathing pattern 0.000846514195998843 0.00701901354182374 0.91863216001147 0.702702702702703 30.3 30 3 abnormal chromosome morphology 0.000846514195998843 0.00701901354182374 0.91863216001147 0.702702702702703 30.3 30 3 abnormal calcium ion homeostasis 0.000846514195998843 0.00701901354182374 0.91863216001147 0.702702702702703 30.3 30 3 increased or absent threshold for auditory brainstem response 1.58913592738553e-20 2.32527977610089e-18 0.918265391781495 0.70242214532872 30.3 30 3 neuron degeneration 0.000177568468162571 0.00187958112576339 0.917880415199677 0.702127659574468 30.3 30 3 abnormal circulating amino acid level 3.79709651097461e-05 0.000495815095593141 0.917392440497285 0.701754385964912 30.3 30 3 decreased white adipose tissue amount 8.22568239815153e-06 0.000127883656033762 0.917050129885159 0.701492537313433 30.3 30 3 short limbs 3.95946412841531e-07 8.83333364971578e-06 0.916601584945132 0.701149425287356 30.3 30 3 abnormal retinal pigmentation 3.95946412841531e-07 8.83333364971578e-06 0.916601584945132 0.701149425287356 30.3 30 3 decreased startle reflex 4.34078007450283e-09 1.4493544208491e-07 0.916216296342801 0.700854700854701 30.3 30 3 abnormal eating behavior 2.68629108361258e-05 0.000369179506656701 0.915098959396042 0.7 30.3 30 3 abnormal long bone epiphyseal plate morphology 2.68629108361258e-05 0.000369179506656701 0.915098959396042 0.7 30.3 30 3 abnormal axon extension 0.000125112719009757 0.00138936557382487 0.915098959396042 0.7 30.3 30 3 decreased respiratory quotient 0.000125112719009757 0.00138936557382487 0.915098959396042 0.7 30.3 30 3 perinatal lethality 0.000592762311102677 0.00529604327058563 0.915098959396042 0.7 30.3 30 3 abnormal hair cycle 0.00288488307782847 0.0189594363437208 0.915098959396042 0.7 30.3 30 3 delayed eyelid opening 0.00288488307782847 0.0189594363437208 0.915098959396042 0.7 30.3 30 3 abnormal response to new environment 0.00288488307782847 0.0189594363437208 0.915098959396042 0.7 30.3 30 3 emphysema 0.00288488307782847 0.0189594363437208 0.915098959396042 0.7 30.3 30 3 enhanced paired-pulse facilitation 0.00288488307782847 0.0189594363437208 0.915098959396042 0.7 30.3 30 3 abnormal microglial cell physiology 0.00288488307782847 0.0189594363437208 0.915098959396042 0.7 30.3 30 3 abnormal cellular respiration 0.00288488307782847 0.0189594363437208 0.915098959396042 0.7 30.3 30 3 abnormal basioccipital bone morphology 0.0147288858126935 0.0674832981135019 0.915098959396042 0.7 30.3 30 3 small gonad 0.0147288858126935 0.0674832981135019 0.915098959396042 0.7 30.3 30 3 abnormal circulating enzyme level 0.0147288858126935 0.0674832981135019 0.915098959396042 0.7 30.3 30 3 increased mammary adenocarcinoma incidence 0.0147288858126935 0.0674832981135019 0.915098959396042 0.7 30.3 30 3 abnormal hearing physiology 0.0147288858126935 0.0674832981135019 0.915098959396042 0.7 30.3 30 3 abnormal incus morphology 0.0147288858126935 0.0674832981135019 0.915098959396042 0.7 30.3 30 3 abnormal lateral semicircular canal morphology 0.0839481258048276 0.233319511664255 0.915098959396042 0.7 30.3 30 3 absent maxillary shelf 0.0839481258048276 0.233319511664255 0.915098959396042 0.7 30.3 30 3 increased cranium width 0.0839481258048276 0.233319511664255 0.915098959396042 0.7 30.3 30 3 jaundice 0.0839481258048276 0.233319511664255 0.915098959396042 0.7 30.3 30 3 small petrosal ganglion 0.0839481258048276 0.233319511664255 0.915098959396042 0.7 30.3 30 3 enlarged testis 0.0839481258048276 0.233319511664255 0.915098959396042 0.7 30.3 30 3 abnormal optic nerve innervation 0.0839481258048276 0.233319511664255 0.915098959396042 0.7 30.3 30 3 abnormal mammary gland physiology 0.0839481258048276 0.233319511664255 0.915098959396042 0.7 30.3 30 3 decreased circulating parathyroid hormone level 0.0839481258048276 0.233319511664255 0.915098959396042 0.7 30.3 30 3 abnormal PNS synaptic transmission 0.0839481258048276 0.233319511664255 0.915098959396042 0.7 30.3 30 3 delayed dark adaptation 0.0839481258048276 0.233319511664255 0.915098959396042 0.7 30.3 30 3 impaired basement membrane formation 0.0839481258048276 0.233319511664255 0.915098959396042 0.7 30.3 30 3 intestinal edema 0.0839481258048276 0.233319511664255 0.915098959396042 0.7 30.3 30 3 absent seminal vesicle 0.0839481258048276 0.233319511664255 0.915098959396042 0.7 30.3 30 3 abnormal hindlimb zeugopod morphology 0.0839481258048276 0.233319511664255 0.915098959396042 0.7 30.3 30 3 abnormal respiratory conducting tube morphology 0.0839481258048276 0.233319511664255 0.915098959396042 0.7 30.3 30 3 decreased cochlear inner hair cell number 0.0839481258048276 0.233319511664255 0.915098959396042 0.7 30.3 30 3 abnormal cochlear inner hair cell physiology 0.0839481258048276 0.233319511664255 0.915098959396042 0.7 30.3 30 3 abnormal gonadal fat pad morphology 0.0839481258048276 0.233319511664255 0.915098959396042 0.7 30.3 30 3 tachypnea 0.0839481258048276 0.233319511664255 0.915098959396042 0.7 30.3 30 3 decreased thyroxine level 0.0839481258048276 0.233319511664255 0.915098959396042 0.7 30.3 30 3 abnormal developmental vascular remodeling 0.0839481258048276 0.233319511664255 0.915098959396042 0.7 30.3 30 3 increased platelet aggregation 0.0839481258048276 0.233319511664255 0.915098959396042 0.7 30.3 30 3 protruding tongue 0.0839481258048276 0.233319511664255 0.915098959396042 0.7 30.3 30 3 increased serotonin level 0.0839481258048276 0.233319511664255 0.915098959396042 0.7 30.3 30 3 abnormal heart and great artery attachment 0.0839481258048276 0.233319511664255 0.915098959396042 0.7 30.3 30 3 abnormal left subclavian artery morphology 0.0839481258048276 0.233319511664255 0.915098959396042 0.7 30.3 30 3 abnormal adaptive thermogenesis 0.0839481258048276 0.233319511664255 0.915098959396042 0.7 30.3 30 3 postnatal lethality 4.00775678846778e-12 2.29179195662382e-10 0.913523918157839 0.698795180722892 30.3 30 3 decreased percent body fat/body weight 4.1405015238961e-06 7.10310175220106e-05 0.913308159084112 0.698630136986301 30.3 30 3 abnormal mesoderm development 8.81910322704612e-05 0.0010132803361329 0.912632385381497 0.69811320754717 30.3 30 3 abnormal placenta development 8.81910322704612e-05 0.0010132803361329 0.912632385381497 0.69811320754717 30.3 30 3 abnormal homeostasis 0.000415481468272366 0.0038894149489765 0.912058763517649 0.697674418604651 30.3 30 3 abnormal double-strand DNA break repair 0.000415481468272366 0.0038894149489765 0.912058763517649 0.697674418604651 30.3 30 3 abnormal motor capabilities/coordination/movement 8.05032435818986e-10 3.08079720630727e-08 0.911137492039349 0.696969696969697 30.3 30 3 abnormal ovarian folliculogenesis 0.00200360321371617 0.0141993247695697 0.911137492039349 0.696969696969697 30.3 30 3 dilated heart atrium 0.00200360321371617 0.0141993247695697 0.911137492039349 0.696969696969697 30.3 30 3 abnormal locomotor coordination 0.00200360321371617 0.0141993247695697 0.911137492039349 0.696969696969697 30.3 30 3 cardiovascular system phenotype 0.00200360321371617 0.0141993247695697 0.911137492039349 0.696969696969697 30.3 30 3 short mandible 6.21919390260303e-05 0.000756491189864305 0.910430087154225 0.696428571428571 30.3 30 3 abnormal eye development 6.21919390260303e-05 0.000756491189864305 0.910430087154225 0.696428571428571 30.3 30 3 abnormal somite development 2.08441866963652e-06 3.84073440053396e-05 0.910134588911072 0.69620253164557 30.3 30 3 abnormal skeleton morphology 1.1483585866779e-08 3.44161684862804e-07 0.909415114927743 0.695652173913043 30.3 30 3 embryonic lethality between implantation and placentation, complete penetrance 0.000291488299747007 0.00289451954339593 0.909415114927743 0.695652173913043 30.3 30 3 bidirectional circling 0.0100533936409378 0.0505208417814805 0.909415114927743 0.695652173913043 30.3 30 3 abnormal nasal cavity morphology 0.0100533936409378 0.0505208417814805 0.909415114927743 0.695652173913043 30.3 30 3 dilated heart 0.0100533936409378 0.0505208417814805 0.909415114927743 0.695652173913043 30.3 30 3 decreased effector memory CD8-positive, alpha-beta T cell number 0.0100533936409378 0.0505208417814805 0.909415114927743 0.695652173913043 30.3 30 3 abnormal vertebral artery topology 0.0100533936409378 0.0505208417814805 0.909415114927743 0.695652173913043 30.3 30 3 abnormal sternum morphology 9.52129801113548e-06 0.000145302017194476 0.909415114927743 0.695652173913043 30.3 30 3 hyperactivity 1.1487750127258e-24 2.19813680319648e-22 0.909108708217862 0.695417789757412 30.3 30 3 respiratory failure 6.56538162216891e-11 3.11074034002765e-09 0.909038701386796 0.695364238410596 30.3 30 3 decreased circulating HDL cholesterol level 1.82934032120964e-09 6.45458730355885e-08 0.908971064578657 0.6953125 30.3 30 3 increased B cell proliferation 4.38759838719632e-05 0.000559700050674403 0.90845175145854 0.694915254237288 30.3 30 3 increased hemoglobin content 4.38759838719632e-05 0.000559700050674403 0.90845175145854 0.694915254237288 30.3 30 3 abnormal pharyngeal arch morphology 0.0013942924230825 0.0106716996997468 0.907836269242105 0.694444444444444 30.3 30 3 enlarged heart 8.14994973719804e-16 8.09312968588861e-14 0.907210175263317 0.693965517241379 30.3 30 3 abnormal spatial learning 1.70218930176047e-11 8.82124143360243e-10 0.906276795896167 0.693251533742331 30.3 30 3 abnormal locomotor activation 5.2867271382e-07 1.15865495649978e-05 0.905042926875206 0.692307692307692 30.3 30 3 abnormal cornea morphology 3.38047202021997e-06 5.96377599311856e-05 0.905042926875206 0.692307692307692 30.3 30 3 no spontaneous movement 0.00689536261850455 0.0367678767706968 0.905042926875206 0.692307692307692 30.3 30 3 decreased bone resorption 0.00689536261850455 0.0367678767706968 0.905042926875206 0.692307692307692 30.3 30 3 short hair 0.0547754624857187 0.182891225413725 0.905042926875206 0.692307692307692 30.3 30 3 increased foot pad pigmentation 0.0547754624857187 0.182891225413725 0.905042926875206 0.692307692307692 30.3 30 3 uterus hypoplasia 0.0547754624857187 0.182891225413725 0.905042926875206 0.692307692307692 30.3 30 3 lymphoid hypoplasia 0.0547754624857187 0.182891225413725 0.905042926875206 0.692307692307692 30.3 30 3 abnormal pulmonary alveolus epithelial cell morphology 0.0547754624857187 0.182891225413725 0.905042926875206 0.692307692307692 30.3 30 3 abnormal tail bud morphology 0.0547754624857187 0.182891225413725 0.905042926875206 0.692307692307692 30.3 30 3 small otic vesicle 0.0547754624857187 0.182891225413725 0.905042926875206 0.692307692307692 30.3 30 3 decreased endocochlear potential 0.0547754624857187 0.182891225413725 0.905042926875206 0.692307692307692 30.3 30 3 increased circulating thyroid-stimulating hormone level 0.0547754624857187 0.182891225413725 0.905042926875206 0.692307692307692 30.3 30 3 increased circulating thyroxine level 0.0547754624857187 0.182891225413725 0.905042926875206 0.692307692307692 30.3 30 3 empty decidua capsularis 0.0547754624857187 0.182891225413725 0.905042926875206 0.692307692307692 30.3 30 3 increased prostaglandin level 0.0547754624857187 0.182891225413725 0.905042926875206 0.692307692307692 30.3 30 3 decreased anxiety-related response 6.69451683381143e-09 2.09466800303219e-07 0.903407799636046 0.691056910569106 30.3 30 3 abnormal contextual conditioning behavior 0.000101148056408612 0.00115151391449163 0.903214557325963 0.690909090909091 30.3 30 3 neonatal lethality, complete penetrance 5.45558722473375e-29 1.65445526718181e-26 0.903058183614515 0.690789473684211 30.3 30 3 disheveled coat 0.000678629726982335 0.00589211673950631 0.902648633417864 0.69047619047619 30.3 30 3 abnormal reproductive system morphology 0.000678629726982335 0.00589211673950631 0.902648633417864 0.69047619047619 30.3 30 3 abnormal retina morphology 4.14387921562574e-14 3.32512888673194e-12 0.902648633417864 0.69047619047619 30.3 30 3 atelectasis 1.09120490936554e-05 0.000163443327567659 0.902210241658069 0.690140845070423 30.3 30 3 corneal opacity 1.09120490936554e-05 0.000163443327567659 0.902210241658069 0.690140845070423 30.3 30 3 thrombocytopenia 3.85751141449113e-10 1.53528954296747e-08 0.901575329454228 0.689655172413793 30.3 30 3 abnormal spermiogenesis 7.11810263722308e-05 0.000851263476446751 0.901575329454228 0.689655172413793 30.3 30 3 thrombocytosis 7.11810263722308e-05 0.000851263476446751 0.901575329454228 0.689655172413793 30.3 30 3 increased mortality induced by gamma-irradiation 0.00474807392971553 0.0280875954819676 0.901575329454228 0.689655172413793 30.3 30 3 polychromatophilia 0.00474807392971553 0.0280875954819676 0.901575329454228 0.689655172413793 30.3 30 3 blood in lymph vessels 0.00474807392971553 0.0280875954819676 0.901575329454228 0.689655172413793 30.3 30 3 decreased insulin secretion 8.52108516680885e-07 1.7517520125981e-05 0.900573579088168 0.688888888888889 30.3 30 3 abnormal cartilage development 0.000474475168763058 0.00438757242490002 0.900573579088168 0.688888888888889 30.3 30 3 lethargy 6.04039536556391e-07 1.30090765989959e-05 0.899636457777983 0.688172043010753 30.3 30 3 abnormal vertebral body morphology 0.003280242634116 0.0205726619442709 0.898757906549684 0.6875 30.3 30 3 polydipsia 0.003280242634116 0.0205726619442709 0.898757906549684 0.6875 30.3 30 3 increased circulating follicle stimulating hormone level 0.003280242634116 0.0205726619442709 0.898757906549684 0.6875 30.3 30 3 abnormal long term potentiation 0.003280242634116 0.0205726619442709 0.898757906549684 0.6875 30.3 30 3 abnormal extraembryonic endoderm formation 0.0363508852739706 0.13268206473808 0.898757906549684 0.6875 30.3 30 3 abnormal olfaction 0.0363508852739706 0.13268206473808 0.898757906549684 0.6875 30.3 30 3 increased pancreatic beta cell number 0.0363508852739706 0.13268206473808 0.898757906549684 0.6875 30.3 30 3 bowed tibia 0.0363508852739706 0.13268206473808 0.898757906549684 0.6875 30.3 30 3 blepharitis 0.0363508852739706 0.13268206473808 0.898757906549684 0.6875 30.3 30 3 decreased circulating triiodothyronine level 0.0363508852739706 0.13268206473808 0.898757906549684 0.6875 30.3 30 3 impaired behavioral response to addictive substance 0.0363508852739706 0.13268206473808 0.898757906549684 0.6875 30.3 30 3 decreased liver cholesterol level 0.0363508852739706 0.13268206473808 0.898757906549684 0.6875 30.3 30 3 dilated respiratory conducting tubes 0.0363508852739706 0.13268206473808 0.898757906549684 0.6875 30.3 30 3 abnormal pulmonary alveolus wall morphology 0.0363508852739706 0.13268206473808 0.898757906549684 0.6875 30.3 30 3 decreased adipocyte glucose uptake 0.0363508852739706 0.13268206473808 0.898757906549684 0.6875 30.3 30 3 abnormal motor coordination/ balance 3.03680958941024e-07 6.96227083286449e-06 0.897932600850373 0.686868686868687 30.3 30 3 increased mean corpuscular hemoglobin 3.03680958941024e-07 6.96227083286449e-06 0.897932600850373 0.686868686868687 30.3 30 3 impaired hematopoiesis 0.000232780267333445 0.00238506272919048 0.897155842545139 0.686274509803922 30.3 30 3 abnormal response to novel object 0.000232780267333445 0.00238506272919048 0.897155842545139 0.686274509803922 30.3 30 3 cataract 1.72262244591175e-08 4.92531417724766e-07 0.896732156196829 0.685950413223141 30.3 30 3 ovary cysts 0.00227248900396007 0.0157999837632098 0.896423470428775 0.685714285714286 30.3 30 3 increased carcinoma incidence 0.00227248900396007 0.0157999837632098 0.896423470428775 0.685714285714286 30.3 30 3 increased circulating serum albumin level 0.00227248900396007 0.0157999837632098 0.896423470428775 0.685714285714286 30.3 30 3 abnormal seminiferous tubule morphology 7.02800842422871e-10 2.75309778823132e-08 0.895400155964816 0.684931506849315 30.3 30 3 abnormal lipid homeostasis 6.17648155451077e-09 1.95719718048988e-07 0.89498689435437 0.684615384615385 30.3 30 3 abnormal cardiovascular system physiology 4.38848934860758e-09 1.45551563395485e-07 0.894457629484853 0.684210526315789 30.3 30 3 abnormal frontal bone morphology 0.00157808944667009 0.0117004396381277 0.894457629484853 0.684210526315789 30.3 30 3 decreased threshold for auditory brainstem response 0.00157808944667009 0.0117004396381277 0.894457629484853 0.684210526315789 30.3 30 3 abnormal nail morphology 0.0244050606923411 0.101095068230139 0.894457629484853 0.684210526315789 30.3 30 3 thin dermal layer 0.0244050606923411 0.101095068230139 0.894457629484853 0.684210526315789 30.3 30 3 abnormal long term depression 0.0244050606923411 0.101095068230139 0.894457629484853 0.684210526315789 30.3 30 3 increased malignant tumor incidence 0.0244050606923411 0.101095068230139 0.894457629484853 0.684210526315789 30.3 30 3 abnormal response to novelty 0.0244050606923411 0.101095068230139 0.894457629484853 0.684210526315789 30.3 30 3 abnormal optic vesicle formation 0.0244050606923411 0.101095068230139 0.894457629484853 0.684210526315789 30.3 30 3 decreased eye pigmentation 0.0244050606923411 0.101095068230139 0.894457629484853 0.684210526315789 30.3 30 3 decreased circulating magnesium level 0.0244050606923411 0.101095068230139 0.894457629484853 0.684210526315789 30.3 30 3 shortened RR interval 0.0244050606923411 0.101095068230139 0.894457629484853 0.684210526315789 30.3 30 3 right-sided stomach 0.0244050606923411 0.101095068230139 0.894457629484853 0.684210526315789 30.3 30 3 abnormal bone structure 1.68012006993405e-12 1.0580502972053e-10 0.89410112983181 0.683937823834197 30.3 30 3 decreased B cell proliferation 6.17994725748007e-06 9.94991508283603e-05 0.893586687294507 0.683544303797468 30.3 30 3 abnormal pulmonary alveolus morphology 3.44025407196593e-07 7.81518904476279e-06 0.893095165464312 0.683168316831683 30.3 30 3 abnormal excitatory postsynaptic potential 4.36659744239078e-06 7.38905519588236e-05 0.892779472581504 0.682926829268293 30.3 30 3 hemopericardium 0.00109813761981388 0.0087833354639454 0.892779472581504 0.682926829268293 30.3 30 3 increased bone trabecula number 0.00109813761981388 0.0087833354639454 0.892779472581504 0.682926829268293 30.3 30 3 increased circulating aspartate transaminase level 5.66796840622017e-05 0.00070169355181396 0.892273361769383 0.682539682539683 30.3 30 3 lethality, incomplete penetrance 0.000765533993660247 0.0064224816500164 0.891330155255885 0.681818181818182 30.3 30 3 increased coping response 0.0165244587535948 0.0724948697523231 0.891330155255885 0.681818181818182 30.3 30 3 abnormal retinal layer morphology 0.0165244587535948 0.0724948697523231 0.891330155255885 0.681818181818182 30.3 30 3 decreased circulating estradiol level 0.0165244587535948 0.0724948697523231 0.891330155255885 0.681818181818182 30.3 30 3 abnormal sperm midpiece morphology 0.0165244587535948 0.0724948697523231 0.891330155255885 0.681818181818182 30.3 30 3 decreased spleen weight 2.80953160670322e-05 0.000380856123796962 0.890468966700082 0.681159420289855 30.3 30 3 abnormal cell nucleus morphology 0.000534517273793805 0.00484375853756681 0.890065857163323 0.680851063829787 30.3 30 3 abnormal embryonic tissue morphology 1.26189349769582e-09 4.65031122299016e-08 0.889308998441245 0.680272108843537 30.3 30 3 abnormal limb morphology 1.39599748076546e-05 0.000203072732947607 0.888953274841869 0.68 30.3 30 3 abnormal liver physiology 5.47149158961381e-07 1.18350741992733e-05 0.888953274841869 0.68 30.3 30 3 decreased double-positive T cell number 5.47149158961381e-07 1.18350741992733e-05 0.888953274841869 0.68 30.3 30 3 abnormal primitive streak morphology 0.011261403645569 0.0548194551239782 0.888953274841869 0.68 30.3 30 3 increased liver glycogen level 0.011261403645569 0.0548194551239782 0.888953274841869 0.68 30.3 30 3 abnormal lens morphology 1.56018868599365e-08 4.51275506559209e-07 0.88854474852071 0.6796875 30.3 30 3 enlarged kidney 0.000261653474540914 0.00262974956735565 0.887966645236051 0.679245283018868 30.3 30 3 decreased exploration in new environment 4.90791262236567e-06 8.16617568437098e-05 0.887085725945142 0.678571428571429 30.3 30 3 small superior cervical ganglion 0.0077141385144247 0.040144183168685 0.887085725945142 0.678571428571429 30.3 30 3 abnormal hormone level 0.0077141385144247 0.040144183168685 0.887085725945142 0.678571428571429 30.3 30 3 increased triglyceride level 0.0077141385144247 0.040144183168685 0.887085725945142 0.678571428571429 30.3 30 3 decreased circulating cholesterol level 2.09212637620226e-11 1.07302357954703e-09 0.885810077791641 0.677595628415301 30.3 30 3 hypoglycemia 1.73192046590224e-06 3.26375163555442e-05 0.885579638125202 0.67741935483871 30.3 30 3 abnormal definitive hematopoiesis 1.73192046590224e-06 3.26375163555442e-05 0.885579638125202 0.67741935483871 30.3 30 3 decreased thymus weight 0.00530630556661034 0.030839801628372 0.885579638125202 0.67741935483871 30.3 30 3 enlarged spleen 4.94046122603268e-17 5.22953076585374e-15 0.885140362511052 0.677083333333333 30.3 30 3 decreased bone mineral density 8.45915062645644e-16 8.09312968588861e-14 0.884628424765239 0.676691729323308 30.3 30 3 overexpanded pulmonary alveoli 0.00366265812483329 0.0225603051733258 0.88433933050878 0.676470588235294 30.3 30 3 abnormal bone remodeling 0.00366265812483329 0.0225603051733258 0.88433933050878 0.676470588235294 30.3 30 3 abnormal long bone metaphysis morphology 0.00253549706284012 0.0172323741634284 0.883300153857183 0.675675675675676 30.3 30 3 abnormal respiratory electron transport chain 0.00253549706284012 0.0172323741634284 0.883300153857183 0.675675675675676 30.3 30 3 abnormal skin pigmentation 0.00175957458695239 0.0125593738451767 0.882416853703326 0.675 30.3 30 3 abnormal organ of Corti morphology 0.00122372254859584 0.00964820868346168 0.881656804733728 0.674418604651163 30.3 30 3 abnormal blood circulation 0.00122372254859584 0.00964820868346168 0.881656804733728 0.674418604651163 30.3 30 3 increased startle reflex 3.86937807004943e-06 6.68408190919997e-05 0.881315209691212 0.674157303370786 30.3 30 3 abnormal forelimb morphology 0.000852648031396233 0.00704638530929611 0.880995892586251 0.673913043478261 30.3 30 3 thymus hypoplasia 9.82761478297516e-09 2.99953273284058e-07 0.880995892586251 0.673913043478261 30.3 30 3 cardiac hypertrophy 1.36558237920263e-06 2.65381731895823e-05 0.880415908456833 0.673469387755102 30.3 30 3 absent kidney 0.000595073002664797 0.00529604327058563 0.880415908456833 0.673469387755102 30.3 30 3 increased sarcoma incidence 0.000595073002664797 0.00529604327058563 0.880415908456833 0.673469387755102 30.3 30 3 decreased circulating creatinine level 0.000595073002664797 0.00529604327058563 0.880415908456833 0.673469387755102 30.3 30 3 abnormal female meiosis 0.000415913317156884 0.0038894149489765 0.879902845573117 0.673076923076923 30.3 30 3 abnormal joint morphology 0.000291071007853243 0.00289451954339593 0.879445753185806 0.672727272727273 30.3 30 3 increased sacral vertebrae number 0.000100421313760498 0.00114586246779467 0.878331590491736 0.671875 30.3 30 3 decreased leukocyte cell number 1.54053137567436e-08 4.49420062068636e-07 0.877884298899226 0.671532846715328 30.3 30 3 abnormal suckling behavior 6.08033320144337e-06 9.94991508283603e-05 0.876474652668287 0.670454545454545 30.3 30 3 hyperglycemia 6.08033320144337e-06 9.94991508283603e-05 0.876474652668287 0.670454545454545 30.3 30 3 abnormal glucose homeostasis 9.00188483918346e-11 4.10865844724199e-09 0.876311405387104 0.67032967032967 30.3 30 3 abnormal B cell differentiation 4.29288956568976e-06 7.31408410592691e-05 0.876311405387104 0.67032967032967 30.3 30 3 enlarged liver 1.51444260935575e-06 2.92652975749656e-05 0.875880432564783 0.67 30.3 30 3 reduced male fertility 5.33892881207652e-13 3.49489090001062e-11 0.875362126042784 0.669603524229075 30.3 30 3 impaired glucose tolerance 4.88812406653122e-14 3.62961451208848e-12 0.875037023385616 0.669354838709677 30.3 30 3 increased leukocyte cell number 8.58261451506416e-09 2.63571032175582e-07 0.874528069570601 0.668965517241379 30.3 30 3 weight loss 2.78220792561669e-10 1.13454790409369e-08 0.874012883668056 0.668571428571429 30.3 30 3 increased circulating HDL cholesterol level 1.1816358219198e-06 2.32357241662095e-05 0.871522818472421 0.666666666666667 30.3 30 3 abnormal heart left ventricle morphology 5.47236491867893e-05 0.000680625386760692 0.871522818472421 0.666666666666667 30.3 30 3 increased lymphocyte cell number 7.78128302234742e-05 0.000910867836145375 0.871522818472421 0.666666666666667 30.3 30 3 diluted coat color 0.000458351106223574 0.00424720432401632 0.871522818472421 0.666666666666667 30.3 30 3 abnormal maxilla morphology 0.000458351106223574 0.00424720432401632 0.871522818472421 0.666666666666667 30.3 30 3 abnormal osteoblast physiology 0.000458351106223574 0.00424720432401632 0.871522818472421 0.666666666666667 30.3 30 3 skin edema 0.00193715340547697 0.0138070747739942 0.871522818472421 0.666666666666667 30.3 30 3 impaired wound healing 0.00402888216571524 0.0246236962830876 0.871522818472421 0.666666666666667 30.3 30 3 narrow eye opening 0.00402888216571524 0.0246236962830876 0.871522818472421 0.666666666666667 30.3 30 3 increased osteoblast cell number 0.00583352147491568 0.0330851185342132 0.871522818472421 0.666666666666667 30.3 30 3 abnormal skin appearance 0.012359833290685 0.0599904103621055 0.871522818472421 0.666666666666667 30.3 30 3 small ears 0.0267074984485411 0.109447944630554 0.871522818472421 0.666666666666667 30.3 30 3 abnormal associative learning 0.0267074984485411 0.109447944630554 0.871522818472421 0.666666666666667 30.3 30 3 abnormal erythrocyte physiology 0.0267074984485411 0.109447944630554 0.871522818472421 0.666666666666667 30.3 30 3 decreased cochlear outer hair cell number 0.0267074984485411 0.109447944630554 0.871522818472421 0.666666666666667 30.3 30 3 abnormal stapes morphology 0.0267074984485411 0.109447944630554 0.871522818472421 0.666666666666667 30.3 30 3 abnormal megakaryocyte differentiation 0.0396844448510198 0.14087566235322 0.871522818472421 0.666666666666667 30.3 30 3 abnormal heart shape 0.0396844448510198 0.14087566235322 0.871522818472421 0.666666666666667 30.3 30 3 underdeveloped hair follicles 0.0396844448510198 0.14087566235322 0.871522818472421 0.666666666666667 30.3 30 3 delayed kidney development 0.0396844448510198 0.14087566235322 0.871522818472421 0.666666666666667 30.3 30 3 right pulmonary isomerism 0.0396844448510198 0.14087566235322 0.871522818472421 0.666666666666667 30.3 30 3 absent spleen 0.0396844448510198 0.14087566235322 0.871522818472421 0.666666666666667 30.3 30 3 abnormal phrenic nerve morphology 0.0396844448510198 0.14087566235322 0.871522818472421 0.666666666666667 30.3 30 3 abnormal Peyer's patch follicle morphology 0.0396844448510198 0.14087566235322 0.871522818472421 0.666666666666667 30.3 30 3 increased circulating renin level 0.0396844448510198 0.14087566235322 0.871522818472421 0.666666666666667 30.3 30 3 abnormal neutrophil morphology 0.0396844448510198 0.14087566235322 0.871522818472421 0.666666666666667 30.3 30 3 increased gastrointestinal tumor incidence 0.0396844448510198 0.14087566235322 0.871522818472421 0.666666666666667 30.3 30 3 abnormal metanephric mesenchyme morphology 0.0396844448510198 0.14087566235322 0.871522818472421 0.666666666666667 30.3 30 3 synostosis 0.141326183455269 0.342140030506066 0.871522818472421 0.666666666666667 30.3 30 3 thick tail 0.141326183455269 0.342140030506066 0.871522818472421 0.666666666666667 30.3 30 3 small geniculate ganglion 0.141326183455269 0.342140030506066 0.871522818472421 0.666666666666667 30.3 30 3 small nodose ganglion 0.141326183455269 0.342140030506066 0.871522818472421 0.666666666666667 30.3 30 3 abnormal vagina orifice morphology 0.141326183455269 0.342140030506066 0.871522818472421 0.666666666666667 30.3 30 3 psoriasis 0.141326183455269 0.342140030506066 0.871522818472421 0.666666666666667 30.3 30 3 wavy vibrissae 0.141326183455269 0.342140030506066 0.871522818472421 0.666666666666667 30.3 30 3 abnormal lung volume 0.141326183455269 0.342140030506066 0.871522818472421 0.666666666666667 30.3 30 3 increased pheochromocytoma incidence 0.141326183455269 0.342140030506066 0.871522818472421 0.666666666666667 30.3 30 3 abnormal germ cell morphology 0.141326183455269 0.342140030506066 0.871522818472421 0.666666666666667 30.3 30 3 genetic imprinting 0.141326183455269 0.342140030506066 0.871522818472421 0.666666666666667 30.3 30 3 enlarged otoliths 0.141326183455269 0.342140030506066 0.871522818472421 0.666666666666667 30.3 30 3 abnormal lens capsule morphology 0.141326183455269 0.342140030506066 0.871522818472421 0.666666666666667 30.3 30 3 priapism 0.141326183455269 0.342140030506066 0.871522818472421 0.666666666666667 30.3 30 3 impaired febrile response 0.141326183455269 0.342140030506066 0.871522818472421 0.666666666666667 30.3 30 3 decreased muscle weight 0.141326183455269 0.342140030506066 0.871522818472421 0.666666666666667 30.3 30 3 short frontal bone 0.141326183455269 0.342140030506066 0.871522818472421 0.666666666666667 30.3 30 3 decreased cochlear hair cell number 0.141326183455269 0.342140030506066 0.871522818472421 0.666666666666667 30.3 30 3 abnormal gallbladder physiology 0.141326183455269 0.342140030506066 0.871522818472421 0.666666666666667 30.3 30 3 abnormal intervertebral disk development 0.141326183455269 0.342140030506066 0.871522818472421 0.666666666666667 30.3 30 3 hemothorax 0.141326183455269 0.342140030506066 0.871522818472421 0.666666666666667 30.3 30 3 increased tidal volume 0.141326183455269 0.342140030506066 0.871522818472421 0.666666666666667 30.3 30 3 enhanced conditioned place preference behavior 0.141326183455269 0.342140030506066 0.871522818472421 0.666666666666667 30.3 30 3 abnormal optic chiasm morphology 0.141326183455269 0.342140030506066 0.871522818472421 0.666666666666667 30.3 30 3 multiflagellated sperm 0.141326183455269 0.342140030506066 0.871522818472421 0.666666666666667 30.3 30 3 abnormal incisor color 0.141326183455269 0.342140030506066 0.871522818472421 0.666666666666667 30.3 30 3 retropulsion 0.141326183455269 0.342140030506066 0.871522818472421 0.666666666666667 30.3 30 3 prolonged RR interval 0.141326183455269 0.342140030506066 0.871522818472421 0.666666666666667 30.3 30 3 abnormal heart left ventricle pressure 0.141326183455269 0.342140030506066 0.871522818472421 0.666666666666667 30.3 30 3 abnormal ureteric bud invasion 0.141326183455269 0.342140030506066 0.871522818472421 0.666666666666667 30.3 30 3 decreased bone trabecular spacing 0.141326183455269 0.342140030506066 0.871522818472421 0.666666666666667 30.3 30 3 decreased fatty acid oxidation 0.141326183455269 0.342140030506066 0.871522818472421 0.666666666666667 30.3 30 3 increased circulating alanine transaminase level 2.71220972523276e-05 0.000371050670896062 0.871522818472421 0.666666666666667 30.3 30 3 abnormal cued conditioning behavior 0.000655662931228001 0.0057126498824156 0.871522818472421 0.666666666666667 30.3 30 3 cochlear inner hair cell degeneration 0.000655662931228001 0.0057126498824156 0.871522818472421 0.666666666666667 30.3 30 3 thymus atrophy 0.000939249614966484 0.00764773622660926 0.871522818472421 0.666666666666667 30.3 30 3 small lens 0.00279031573850257 0.018810055283266 0.871522818472421 0.666666666666667 30.3 30 3 abnormal iris morphology 0.00279031573850257 0.018810055283266 0.871522818472421 0.666666666666667 30.3 30 3 abnormal response to injury 0.00279031573850257 0.018810055283266 0.871522818472421 0.666666666666667 30.3 30 3 abnormal circulating hormone level 0.00279031573850257 0.018810055283266 0.871522818472421 0.666666666666667 30.3 30 3 abnormal synaptic transmission 0.00847445563348956 0.043464347192382 0.871522818472421 0.666666666666667 30.3 30 3 liver hemorrhage 0.00847445563348956 0.043464347192382 0.871522818472421 0.666666666666667 30.3 30 3 blindness 0.0181139268870745 0.0790498125115751 0.871522818472421 0.666666666666667 30.3 30 3 abnormal impulse conducting system conduction 0.0181139268870745 0.0790498125115751 0.871522818472421 0.666666666666667 30.3 30 3 abnormal lung saccule morphology 0.0181139268870745 0.0790498125115751 0.871522818472421 0.666666666666667 30.3 30 3 macrocytosis 0.0595796403074334 0.19135488090993 0.871522818472421 0.666666666666667 30.3 30 3 no suckling reflex 0.0595796403074334 0.19135488090993 0.871522818472421 0.666666666666667 30.3 30 3 arthritis 0.0595796403074334 0.19135488090993 0.871522818472421 0.666666666666667 30.3 30 3 abnormal cerebral aqueduct morphology 0.0595796403074334 0.19135488090993 0.871522818472421 0.666666666666667 30.3 30 3 decreased thymocyte apoptosis 0.0595796403074334 0.19135488090993 0.871522818472421 0.666666666666667 30.3 30 3 abnormal aorta wall morphology 0.0595796403074334 0.19135488090993 0.871522818472421 0.666666666666667 30.3 30 3 abnormal branching involved in lung morphogenesis 0.0595796403074334 0.19135488090993 0.871522818472421 0.666666666666667 30.3 30 3 abnormal adipose tissue distribution 0.0907575664236218 0.248770739921498 0.871522818472421 0.666666666666667 30.3 30 3 abnormal mineral level 0.0907575664236218 0.248770739921498 0.871522818472421 0.666666666666667 30.3 30 3 abnormal glossopharyngeal nerve morphology 0.0907575664236218 0.248770739921498 0.871522818472421 0.666666666666667 30.3 30 3 absent optic nerve 0.0907575664236218 0.248770739921498 0.871522818472421 0.666666666666667 30.3 30 3 abnormal mating frequency 0.0907575664236218 0.248770739921498 0.871522818472421 0.666666666666667 30.3 30 3 altered tumor susceptibility 0.0907575664236218 0.248770739921498 0.871522818472421 0.666666666666667 30.3 30 3 increased circulating parathyroid hormone level 0.0907575664236218 0.248770739921498 0.871522818472421 0.666666666666667 30.3 30 3 decreased synaptic depression 0.0907575664236218 0.248770739921498 0.871522818472421 0.666666666666667 30.3 30 3 abnormal gastrocnemius morphology 0.0907575664236218 0.248770739921498 0.871522818472421 0.666666666666667 30.3 30 3 abnormal nucleotide metabolism 0.0907575664236218 0.248770739921498 0.871522818472421 0.666666666666667 30.3 30 3 decreased left ventricle systolic pressure 0.0907575664236218 0.248770739921498 0.871522818472421 0.666666666666667 30.3 30 3 abnormal defecation 0.0907575664236218 0.248770739921498 0.871522818472421 0.666666666666667 30.3 30 3 increased hepatocyte proliferation 0.0907575664236218 0.248770739921498 0.871522818472421 0.666666666666667 30.3 30 3 increased placenta weight 0.0907575664236218 0.248770739921498 0.871522818472421 0.666666666666667 30.3 30 3 hematuria 0.0907575664236218 0.248770739921498 0.871522818472421 0.666666666666667 30.3 30 3 abnormal somatic nervous system physiology 0.0907575664236218 0.248770739921498 0.871522818472421 0.666666666666667 30.3 30 3 hemoperitoneum 0.0907575664236218 0.248770739921498 0.871522818472421 0.666666666666667 30.3 30 3 abnormal thymus corticomedullary boundary morphology 0.0907575664236218 0.248770739921498 0.871522818472421 0.666666666666667 30.3 30 3 decreased mammary gland epithelial cell proliferation 0.0907575664236218 0.248770739921498 0.871522818472421 0.666666666666667 30.3 30 3 decreased T cell number 2.64083769283875e-09 9.06080518749848e-08 0.868816225868469 0.664596273291925 30.3 30 3 alopecia 5.19874952667713e-06 8.62125963173958e-05 0.866935856269934 0.663157894736842 30.3 30 3 increased circulating triglyceride level 2.27061824218507e-08 6.31079651110097e-07 0.865512316276059 0.662068965517241 30.3 30 3 increased blood urea nitrogen level 2.27061824218507e-08 6.31079651110097e-07 0.865512316276059 0.662068965517241 30.3 30 3 male infertility 2.08413676002748e-25 4.34613421798464e-23 0.865458544387622 0.662027833001988 30.3 30 3 decreased circulating alanine transaminase level 0.000121223792918493 0.00135221607571638 0.865114562454241 0.661764705882353 30.3 30 3 female infertility 4.38583666132483e-14 3.32773679460857e-12 0.864970015326011 0.661654135338346 30.3 30 3 abnormal bone mineralization 3.56445142362688e-07 8.02404788802884e-06 0.864320150551161 0.661157024793388 30.3 30 3 abnormal spleen morphology 1.13421626074387e-09 4.21098947552296e-08 0.864009690726969 0.660919540229885 30.3 30 3 increased monocyte cell number 4.01324417720597e-06 6.90861238117637e-05 0.862807590287696 0.66 30.3 30 3 decreased IgM level 5.67870818999062e-06 9.35482557788189e-05 0.862538047147963 0.65979381443299 30.3 30 3 pulmonary hypoplasia 0.00146902637425092 0.011056590335701 0.862251299126969 0.659574468085106 30.3 30 3 increased respiratory quotient 0.00146902637425092 0.011056590335701 0.862251299126969 0.659574468085106 30.3 30 3 reduced female fertility 2.88032569180054e-12 1.72646027912141e-10 0.862131408790606 0.65948275862069 30.3 30 3 small spleen 1.13830724662114e-05 0.000168638400511249 0.861945644643053 0.659340659340659 30.3 30 3 increased T cell number 1.61264986543282e-05 0.000231876678627984 0.861619150080689 0.659090909090909 30.3 30 3 osteoporosis 0.00210955375480467 0.0147817322959904 0.861619150080689 0.659090909090909 30.3 30 3 muscular atrophy 0.00210955375480467 0.0147817322959904 0.861619150080689 0.659090909090909 30.3 30 3 renal interstitial fibrosis 0.00210955375480467 0.0147817322959904 0.861619150080689 0.659090909090909 30.3 30 3 cochlear hair cell degeneration 0.00210955375480467 0.0147817322959904 0.861619150080689 0.659090909090909 30.3 30 3 embryonic lethality, incomplete penetrance 0.00210955375480467 0.0147817322959904 0.861619150080689 0.659090909090909 30.3 30 3 no abnormal phenotype detected 7.02796901003736e-84 1.74820729124679e-80 0.861225286611507 0.658789625360231 30.3 30 3 hunched posture 4.59895250229566e-05 0.000580705296926926 0.860490884061377 0.658227848101266 30.3 30 3 increased bone marrow cell number 0.00437666555547481 0.026045348251779 0.860055412966204 0.657894736842105 30.3 30 3 increased grooming behavior 0.00437666555547481 0.026045348251779 0.860055412966204 0.657894736842105 30.3 30 3 abnormal midbrain development 0.00632714893984027 0.0353680516580959 0.859072492494243 0.657142857142857 30.3 30 3 increased total body fat amount 1.50509496503132e-07 3.65260851269796e-06 0.858515015211638 0.656716417910448 30.3 30 3 deafness 6.17497212845244e-06 9.94991508283603e-05 0.858317927283444 0.656565656565657 30.3 30 3 decreased lymphocyte cell number 2.99437491126342e-07 6.92884427141188e-06 0.857905274433789 0.65625 30.3 30 3 abnormal osteoclast physiology 0.000267065392898303 0.00267334070355947 0.857905274433789 0.65625 30.3 30 3 abnormal tooth morphology 0.000267065392898303 0.00267334070355947 0.857905274433789 0.65625 30.3 30 3 abnormal lymphatic vessel morphology 0.00917424389228129 0.0466209023126654 0.857905274433789 0.65625 30.3 30 3 increased dopamine level 0.00917424389228129 0.0466209023126654 0.857905274433789 0.65625 30.3 30 3 pancreatic islet hyperplasia 0.00917424389228129 0.0466209023126654 0.857905274433789 0.65625 30.3 30 3 abnormal enzyme/coenzyme activity 1.47976855409308e-08 4.40219813692585e-07 0.857645066585917 0.656050955414013 30.3 30 3 decreased B cell number 1.03456051273456e-10 4.67903504623132e-09 0.856715391944977 0.655339805825243 30.3 30 3 abnormal enzyme/coenzyme level 0.000542907812402152 0.00488420681139368 0.856496562981517 0.655172413793103 30.3 30 3 abnormal spinal nerve morphology 0.0133496612253721 0.0638601582656022 0.856496562981517 0.655172413793103 30.3 30 3 decreased bone strength 0.0133496612253721 0.0638601582656022 0.856496562981517 0.655172413793103 30.3 30 3 abnormal nervous system electrophysiology 3.51502832652892e-05 0.000465086859693654 0.855959910999699 0.654761904761905 30.3 30 3 increased sensitivity to xenobiotic induced morbidity/mortality 2.36914184184553e-06 4.31309441323823e-05 0.855676949045649 0.654545454545455 30.3 30 3 decreased circulating calcium level 0.00077530287155685 0.00649348785521099 0.855676949045649 0.654545454545455 30.3 30 3 cachexia 4.72995710189133e-06 7.92307629020518e-05 0.854762764271028 0.653846153846154 30.3 30 3 absent gastric milk in neonates 7.07057008780921e-05 0.000849663917556783 0.854762764271028 0.653846153846154 30.3 30 3 small seminal vesicle 0.0195083700300241 0.0839568692901122 0.854762764271028 0.653846153846154 30.3 30 3 abnormal T cell differentiation 6.68618762820823e-06 0.000106274068531425 0.854264940878907 0.653465346534653 30.3 30 3 impaired righting response 1.33733587183889e-05 0.000195683704776426 0.853174969662475 0.652631578947368 30.3 30 3 abnormal spermatogenesis 1.71573483434231e-09 6.09698628632356e-08 0.852576670244759 0.652173913043478 30.3 30 3 abnormal blood vessel physiology 0.0286577058398266 0.114815021873667 0.852576670244759 0.652173913043478 30.3 30 3 failure of embryo implantation 0.0286577058398266 0.114815021873667 0.852576670244759 0.652173913043478 30.3 30 3 abnormal cochlear ganglion morphology 0.0286577058398266 0.114815021873667 0.852576670244759 0.652173913043478 30.3 30 3 abnormal basicranium morphology 0.0286577058398266 0.114815021873667 0.852576670244759 0.652173913043478 30.3 30 3 abnormal hepatocyte physiology 0.0286577058398266 0.114815021873667 0.852576670244759 0.652173913043478 30.3 30 3 abnormal testis morphology 1.81330494690607e-06 3.40422343805952e-05 0.852576670244759 0.652173913043478 30.3 30 3 abnormal neuron differentiation 2.55973312255342e-06 4.5808173685983e-05 0.852069184131518 0.651785714285714 30.3 30 3 insulin resistance 3.50479125149246e-07 7.92560748917046e-06 0.851715481688956 0.651515151515151 30.3 30 3 abnormal vertebrae morphology 3.61425504914548e-06 6.26512852595775e-05 0.85153376300287 0.651376146788991 30.3 30 3 abnormal incisor morphology 0.000584543655205601 0.00523982826062678 0.84973474801061 0.65 30.3 30 3 waved hair 0.0423750997545436 0.148566681662336 0.84973474801061 0.65 30.3 30 3 decreased myocardial infarction size 0.0423750997545436 0.148566681662336 0.84973474801061 0.65 30.3 30 3 abnormal hyoid bone morphology 0.0423750997545436 0.148566681662336 0.84973474801061 0.65 30.3 30 3 decreased circulating VLDL cholesterol level 0.0423750997545436 0.148566681662336 0.84973474801061 0.65 30.3 30 3 abnormal craniofacial bone morphology 0.000833663004458329 0.0069471917038194 0.848588007459989 0.649122807017544 30.3 30 3 increased macrophage cell number 0.000833663004458329 0.0069471917038194 0.848588007459989 0.649122807017544 30.3 30 3 abnormal branching of the mammary ductal tree 0.006785900817177 0.0367678767706968 0.847968147702896 0.648648648648649 30.3 30 3 decreased circulating chloride level 0.006785900817177 0.0367678767706968 0.847968147702896 0.648648648648649 30.3 30 3 abnormal pancreatic beta cell physiology 0.006785900817177 0.0367678767706968 0.847968147702896 0.648648648648649 30.3 30 3 abnormal hair follicle development 0.006785900817177 0.0367678767706968 0.847968147702896 0.648648648648649 30.3 30 3 increased thermal nociceptive threshold 2.88041079407669e-05 0.000389403361427488 0.847579883899003 0.648351648351648 30.3 30 3 decreased tumor growth/size 0.00119022704649068 0.00944398653315971 0.847313851292631 0.648148148148148 30.3 30 3 abnormal liver morphology 5.53394100592268e-09 1.77621654867518e-07 0.847178605665928 0.64804469273743 30.3 30 3 improved glucose tolerance 1.08468639513237e-09 4.05737956073951e-08 0.847066821015286 0.647959183673469 30.3 30 3 increased circulating free fatty acid level 0.000217646270881403 0.00226525145948741 0.846972879923902 0.647887323943662 30.3 30 3 spleen hypoplasia 7.74788024983592e-06 0.00012159528152345 0.846622166516066 0.647619047619048 30.3 30 3 abnormal inhibitory postsynaptic currents 0.000309212599240875 0.00305224738337967 0.845889794399702 0.647058823529412 30.3 30 3 abnormal endoderm development 0.00981343761673346 0.0496157033976107 0.845889794399702 0.647058823529412 30.3 30 3 abnormal vision 0.00981343761673346 0.0496157033976107 0.845889794399702 0.647058823529412 30.3 30 3 abnormal spleen red pulp morphology 0.00981343761673346 0.0496157033976107 0.845889794399702 0.647058823529412 30.3 30 3 decreased pancreatic beta cell number 0.00981343761673346 0.0496157033976107 0.845889794399702 0.647058823529412 30.3 30 3 increased incidence of corneal inflammation 0.0631921496919385 0.201526246613714 0.845889794399702 0.647058823529412 30.3 30 3 abnormal cranial suture morphology 0.0631921496919385 0.201526246613714 0.845889794399702 0.647058823529412 30.3 30 3 decreased vasoconstriction 0.0631921496919385 0.201526246613714 0.845889794399702 0.647058823529412 30.3 30 3 absence seizures 0.0631921496919385 0.201526246613714 0.845889794399702 0.647058823529412 30.3 30 3 abnormal tarsal bone morphology 0.0631921496919385 0.201526246613714 0.845889794399702 0.647058823529412 30.3 30 3 coloboma 0.0631921496919385 0.201526246613714 0.845889794399702 0.647058823529412 30.3 30 3 increased circulating magnesium level 0.0631921496919385 0.201526246613714 0.845889794399702 0.647058823529412 30.3 30 3 abnormal survival 0.0631921496919385 0.201526246613714 0.845889794399702 0.647058823529412 30.3 30 3 abnormal ductus venosus valve morphology 0.0631921496919385 0.201526246613714 0.845889794399702 0.647058823529412 30.3 30 3 decreased body fat mass 0.0631921496919385 0.201526246613714 0.845889794399702 0.647058823529412 30.3 30 3 kinked tail 1.09400257447298e-05 0.000163443327567659 0.845889794399702 0.647058823529412 30.3 30 3 abnormal gastrulation 0.00170131662748133 0.0124200277558198 0.845889794399702 0.647058823529412 30.3 30 3 increased spleen weight 4.17002984128114e-06 7.12917472865074e-05 0.844528748873717 0.646017699115044 30.3 30 3 increased susceptibility to pharmacologically induced seizures 2.18284893429792e-05 0.000303342833746709 0.844287730395157 0.645833333333333 30.3 30 3 decreased food intake 0.00011572444975709 0.00130255460982244 0.843942982444812 0.645569620253165 30.3 30 3 decreased circulating glucose level 7.24408028404692e-13 4.68042849521213e-11 0.843409179166859 0.645161290322581 30.3 30 3 increased lung adenoma incidence 0.0142347284823609 0.0657968031712751 0.843409179166859 0.645161290322581 30.3 30 3 abnormal podocyte morphology 0.0142347284823609 0.0657968031712751 0.843409179166859 0.645161290322581 30.3 30 3 abnormal axial skeleton morphology 0.000164020143937997 0.00174732380319386 0.84285430470688 0.644736842105263 30.3 30 3 abnormal rib morphology 6.10861658145515e-07 1.30992963330773e-05 0.842472057856673 0.644444444444444 30.3 30 3 irregular heartbeat 0.00349050133162664 0.0217882611353106 0.842472057856673 0.644444444444444 30.3 30 3 syndactyly 0.000890671277245896 0.00734840730397733 0.841979672083525 0.644067796610169 30.3 30 3 seminiferous tubule degeneration 0.000232589418586542 0.00238506272919048 0.841676146606927 0.643835616438356 30.3 30 3 abnormal jaw morphology 0.0207220838879538 0.0889494109944522 0.840397003526977 0.642857142857143 30.3 30 3 enhanced coordination 0.0207220838879538 0.0889494109944522 0.840397003526977 0.642857142857143 30.3 30 3 hypoxia 0.0207220838879538 0.0889494109944522 0.840397003526977 0.642857142857143 30.3 30 3 abnormal vasoconstriction 0.0953159433077371 0.259165439798308 0.840397003526977 0.642857142857143 30.3 30 3 absent atrioventricular cushions 0.0953159433077371 0.259165439798308 0.840397003526977 0.642857142857143 30.3 30 3 abnormal zigzag hair morphology 0.0953159433077371 0.259165439798308 0.840397003526977 0.642857142857143 30.3 30 3 abnormal pinna reflex 0.0953159433077371 0.259165439798308 0.840397003526977 0.642857142857143 30.3 30 3 extended life span 0.0953159433077371 0.259165439798308 0.840397003526977 0.642857142857143 30.3 30 3 abnormal endplate potential 0.0953159433077371 0.259165439798308 0.840397003526977 0.642857142857143 30.3 30 3 absent otoliths 0.0953159433077371 0.259165439798308 0.840397003526977 0.642857142857143 30.3 30 3 intestinal obstruction 0.0953159433077371 0.259165439798308 0.840397003526977 0.642857142857143 30.3 30 3 abnormal sagittal suture morphology 0.0953159433077371 0.259165439798308 0.840397003526977 0.642857142857143 30.3 30 3 decreased CNS synapse formation 0.0953159433077371 0.259165439798308 0.840397003526977 0.642857142857143 30.3 30 3 abnormal glucose tolerance 0.0953159433077371 0.259165439798308 0.840397003526977 0.642857142857143 30.3 30 3 increased stomach tumor incidence 0.0953159433077371 0.259165439798308 0.840397003526977 0.642857142857143 30.3 30 3 increased lung compliance 0.0953159433077371 0.259165439798308 0.840397003526977 0.642857142857143 30.3 30 3 hydronephrosis 8.72127787382155e-05 0.00100669042743068 0.840397003526977 0.642857142857143 30.3 30 3 increased circulating cholesterol level 1.87970362050975e-08 5.34372886402057e-07 0.839335896199291 0.642045454545455 30.3 30 3 increased B cell number 4.74994112490554e-06 7.92985137463257e-05 0.838002710069635 0.641025641025641 30.3 30 3 decreased litter size 1.84871538889876e-12 1.13547642713226e-10 0.837406266859621 0.640569395017794 30.3 30 3 spontaneous skin ulceration 0.0302961904275287 0.119149049309846 0.836661905733524 0.64 30.3 30 3 decreased placenta weight 0.0302961904275287 0.119149049309846 0.836661905733524 0.64 30.3 30 3 cochlear outer hair cell degeneration 0.000350498593785285 0.00339255618502877 0.835209367702736 0.638888888888889 30.3 30 3 abnormal lipid level 0.000131055695147713 0.00144248248530945 0.83477185624768 0.63855421686747 30.3 30 3 abnormal tibia morphology 0.00369947231338144 0.0226940502577962 0.834436741090615 0.638297872340426 30.3 30 3 hepatic necrosis 0.00369947231338144 0.0226940502577962 0.834436741090615 0.638297872340426 30.3 30 3 decreased bone trabecula number 0.00369947231338144 0.0226940502577962 0.834436741090615 0.638297872340426 30.3 30 3 dermatitis 0.00134594596189064 0.0103175364567117 0.833957179745161 0.637931034482759 30.3 30 3 glomerulosclerosis 0.00134594596189064 0.0103175364567117 0.833957179745161 0.637931034482759 30.3 30 3 small ovary 6.96148981236898e-05 0.000838581399916118 0.833214123154952 0.637362637362637 30.3 30 3 decreased macrophage cell number 0.00529773119281002 0.030839801628372 0.831908144905492 0.636363636363636 30.3 30 3 abnormal abdominal fat pad morphology 0.0445278179146972 0.155130177959117 0.831908144905492 0.636363636363636 30.3 30 3 abnormal basisphenoid bone morphology 0.0445278179146972 0.155130177959117 0.831908144905492 0.636363636363636 30.3 30 3 abnormal enterocyte morphology 0.0445278179146972 0.155130177959117 0.831908144905492 0.636363636363636 30.3 30 3 increased body size 0.0445278179146972 0.155130177959117 0.831908144905492 0.636363636363636 30.3 30 3 increased skin papilloma incidence 0.0445278179146972 0.155130177959117 0.831908144905492 0.636363636363636 30.3 30 3 decreased cardiac output 0.0445278179146972 0.155130177959117 0.831908144905492 0.636363636363636 30.3 30 3 abnormal blood-brain barrier function 0.0445278179146972 0.155130177959117 0.831908144905492 0.636363636363636 30.3 30 3 abnormal mesenteric lymph node morphology 0.0445278179146972 0.155130177959117 0.831908144905492 0.636363636363636 30.3 30 3 abnormal awl hair morphology 0.146111635954658 0.349473744651166 0.831908144905492 0.636363636363636 30.3 30 3 enlarged cranium 0.146111635954658 0.349473744651166 0.831908144905492 0.636363636363636 30.3 30 3 failure of somite differentiation 0.146111635954658 0.349473744651166 0.831908144905492 0.636363636363636 30.3 30 3 abnormal hypothalamus secretion 0.146111635954658 0.349473744651166 0.831908144905492 0.636363636363636 30.3 30 3 vasculitis 0.146111635954658 0.349473744651166 0.831908144905492 0.636363636363636 30.3 30 3 secondary sex reversal 0.146111635954658 0.349473744651166 0.831908144905492 0.636363636363636 30.3 30 3 abnormal primary sex determination 0.146111635954658 0.349473744651166 0.831908144905492 0.636363636363636 30.3 30 3 abnormal bronchiole morphology 0.146111635954658 0.349473744651166 0.831908144905492 0.636363636363636 30.3 30 3 loss of cortex neurons 0.146111635954658 0.349473744651166 0.831908144905492 0.636363636363636 30.3 30 3 pulmonary hypertension 0.146111635954658 0.349473744651166 0.831908144905492 0.636363636363636 30.3 30 3 abnormal radial glial cell morphology 0.146111635954658 0.349473744651166 0.831908144905492 0.636363636363636 30.3 30 3 abnormal superovulation 0.146111635954658 0.349473744651166 0.831908144905492 0.636363636363636 30.3 30 3 increased number of Howell-Jolly bodies 0.146111635954658 0.349473744651166 0.831908144905492 0.636363636363636 30.3 30 3 aberrant origin of the right subclavian artery 0.146111635954658 0.349473744651166 0.831908144905492 0.636363636363636 30.3 30 3 abnormal pulmonary alveolar sac morphology 0.146111635954658 0.349473744651166 0.831908144905492 0.636363636363636 30.3 30 3 decreased core body temperature 0.146111635954658 0.349473744651166 0.831908144905492 0.636363636363636 30.3 30 3 abnormal brain ependyma motile cilium morphology 0.146111635954658 0.349473744651166 0.831908144905492 0.636363636363636 30.3 30 3 chylous ascites 0.146111635954658 0.349473744651166 0.831908144905492 0.636363636363636 30.3 30 3 abnormal eye electrophysiology 5.34862969441114e-06 8.84034309956658e-05 0.831908144905492 0.636363636363636 30.3 30 3 abnormal tooth development 0.0150205081226711 0.0674832981135019 0.831908144905492 0.636363636363636 30.3 30 3 abnormal skeleton physiology 0.0150205081226711 0.0674832981135019 0.831908144905492 0.636363636363636 30.3 30 3 abnormal T cell subpopulation ratio 0.0150205081226711 0.0674832981135019 0.831908144905492 0.636363636363636 30.3 30 3 abnormal middle ear ossicle morphology 0.0150205081226711 0.0674832981135019 0.831908144905492 0.636363636363636 30.3 30 3 increased granulocyte number 0.000370621578044409 0.0035595412177045 0.830302144625752 0.635135135135135 30.3 30 3 abnormal brain wave pattern 0.00273090501516171 0.018509880722656 0.829622682968939 0.634615384615385 30.3 30 3 liver fibrosis 0.00759808286129072 0.0396647032895292 0.829009510254254 0.634146341463415 30.3 30 3 short humerus 0.00759808286129072 0.0396647032895292 0.829009510254254 0.634146341463415 30.3 30 3 lethality at weaning, incomplete penetrance 0.00759808286129072 0.0396647032895292 0.829009510254254 0.634146341463415 30.3 30 3 abnormal ovary morphology 0.000524471873778475 0.00476140067891955 0.828560426012513 0.633802816901408 30.3 30 3 abnormal lactation 0.0217704708840784 0.0911684281551262 0.8279466775488 0.633333333333333 30.3 30 3 abnormal fat pad morphology 0.0217704708840784 0.0911684281551262 0.8279466775488 0.633333333333333 30.3 30 3 increased anxiety-related response 1.62477162927082e-06 3.09702638146449e-05 0.827633180132083 0.633093525179856 30.3 30 3 organ of Corti degeneration 0.00389549712618784 0.0238671160132814 0.827057368550358 0.63265306122449 30.3 30 3 abnormal triglyceride level 0.0658776748373264 0.208619625917058 0.825653196447556 0.631578947368421 30.3 30 3 abnormal neurotransmitter level 0.0658776748373264 0.208619625917058 0.825653196447556 0.631578947368421 30.3 30 3 abnormal metatarsal bone morphology 0.0658776748373264 0.208619625917058 0.825653196447556 0.631578947368421 30.3 30 3 abnormal digestive system development 0.0658776748373264 0.208619625917058 0.825653196447556 0.631578947368421 30.3 30 3 maternal imprinting 0.0658776748373264 0.208619625917058 0.825653196447556 0.631578947368421 30.3 30 3 increased circulating VLDL cholesterol level 0.0658776748373264 0.208619625917058 0.825653196447556 0.631578947368421 30.3 30 3 eyelids fail to open 0.0658776748373264 0.208619625917058 0.825653196447556 0.631578947368421 30.3 30 3 decreased fertilization frequency 0.0658776748373264 0.208619625917058 0.825653196447556 0.631578947368421 30.3 30 3 increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 0.0658776748373264 0.208619625917058 0.825653196447556 0.631578947368421 30.3 30 3 abnormal lung morphology 1.17267505532347e-05 0.000172605278113439 0.823918630908801 0.630252100840336 30.3 30 3 abnormal fertility/fecundity 0.000551380892272039 0.00495148003439241 0.82376814348763 0.63013698630137 30.3 30 3 decreased heart rate 5.79347918151252e-05 0.000708170981032549 0.823589063456437 0.63 30.3 30 3 abnormal mandible morphology 0.00286679621676578 0.0189594363437208 0.823104884112842 0.62962962962963 30.3 30 3 thin epidermis 0.0316608824869003 0.124319566197576 0.823104884112842 0.62962962962963 30.3 30 3 cryptorchism 0.0316608824869003 0.124319566197576 0.823104884112842 0.62962962962963 30.3 30 3 azoospermia 5.18663168676462e-07 1.14174746202009e-05 0.822191338181529 0.628930817610063 30.3 30 3 impaired behavioral response to xenobiotic 0.015713310762245 0.0692415598247732 0.821721514559711 0.628571428571429 30.3 30 3 abnormal excitatory postsynaptic currents 0.000409510366675349 0.003851255338771 0.821242655868242 0.628205128205128 30.3 30 3 abnormal cervical vertebrae morphology 0.00407847206718532 0.0248656844782438 0.820256770326984 0.627450980392157 30.3 30 3 abnormal gluconeogenesis 0.00407847206718532 0.0248656844782438 0.820256770326984 0.627450980392157 30.3 30 3 decreased compact bone thickness 0.00110118406308304 0.00879356454869679 0.819491605429291 0.626865671641791 30.3 30 3 abnormal CNS synaptic transmission 8.52827451530555e-05 0.000986701528224305 0.818703253716516 0.626262626262626 30.3 30 3 short femur 0.000226007293605054 0.00234247142851072 0.817052642317894 0.625 30.3 30 3 teratozoospermia 0.000226007293605054 0.00234247142851072 0.817052642317894 0.625 30.3 30 3 abnormal inflammatory response 0.000814427340433776 0.00680970759438325 0.817052642317894 0.625 30.3 30 3 abnormal lumbar vertebrae morphology 0.022668869465827 0.0948508205151297 0.817052642317894 0.625 30.3 30 3 abnormal tympanic ring morphology 0.0982942320298716 0.265048132438272 0.817052642317894 0.625 30.3 30 3 failure of tooth eruption 0.0982942320298716 0.265048132438272 0.817052642317894 0.625 30.3 30 3 abnormal bone marrow cell number 0.0982942320298716 0.265048132438272 0.817052642317894 0.625 30.3 30 3 delayed hair appearance 0.0982942320298716 0.265048132438272 0.817052642317894 0.625 30.3 30 3 intraventricular hemorrhage 0.0982942320298716 0.265048132438272 0.817052642317894 0.625 30.3 30 3 abnormal meiosis 0.0982942320298716 0.265048132438272 0.817052642317894 0.625 30.3 30 3 white spotting 0.0982942320298716 0.265048132438272 0.817052642317894 0.625 30.3 30 3 abnormal pulmonary elastic fiber morphology 0.0982942320298716 0.265048132438272 0.817052642317894 0.625 30.3 30 3 increased thymus weight 0.0982942320298716 0.265048132438272 0.817052642317894 0.625 30.3 30 3 abnormal level of surface class II molecules 0.0982942320298716 0.265048132438272 0.817052642317894 0.625 30.3 30 3 abnormal ear pigmentation 0.229591109532048 0.428438023226534 0.817052642317894 0.625 30.3 30 3 absent pre-B cells 0.229591109532048 0.428438023226534 0.817052642317894 0.625 30.3 30 3 clubfoot 0.229591109532048 0.428438023226534 0.817052642317894 0.625 30.3 30 3 absent mammary gland 0.229591109532048 0.428438023226534 0.817052642317894 0.625 30.3 30 3 absent skin pigmentation 0.229591109532048 0.428438023226534 0.817052642317894 0.625 30.3 30 3 abnormal pupil morphology 0.229591109532048 0.428438023226534 0.817052642317894 0.625 30.3 30 3 unidirectional circling 0.229591109532048 0.428438023226534 0.817052642317894 0.625 30.3 30 3 spinning 0.229591109532048 0.428438023226534 0.817052642317894 0.625 30.3 30 3 abnormal urination 0.229591109532048 0.428438023226534 0.817052642317894 0.625 30.3 30 3 preneoplasia 0.229591109532048 0.428438023226534 0.817052642317894 0.625 30.3 30 3 coarse hair 0.229591109532048 0.428438023226534 0.817052642317894 0.625 30.3 30 3 head spot 0.229591109532048 0.428438023226534 0.817052642317894 0.625 30.3 30 3 hypospadia 0.229591109532048 0.428438023226534 0.817052642317894 0.625 30.3 30 3 absent tympanic ring 0.229591109532048 0.428438023226534 0.817052642317894 0.625 30.3 30 3 calcified muscle 0.229591109532048 0.428438023226534 0.817052642317894 0.625 30.3 30 3 binucleate 0.229591109532048 0.428438023226534 0.817052642317894 0.625 30.3 30 3 increased left ventricle systolic pressure 0.229591109532048 0.428438023226534 0.817052642317894 0.625 30.3 30 3 abnormal lateral ganglionic eminence morphology 0.229591109532048 0.428438023226534 0.817052642317894 0.625 30.3 30 3 long femur 0.229591109532048 0.428438023226534 0.817052642317894 0.625 30.3 30 3 thin stria vascularis 0.229591109532048 0.428438023226534 0.817052642317894 0.625 30.3 30 3 absent cochlear microphonics 0.229591109532048 0.428438023226534 0.817052642317894 0.625 30.3 30 3 abnormal kidney epithelium morphology 0.229591109532048 0.428438023226534 0.817052642317894 0.625 30.3 30 3 abnormal circulating corticosterone level 0.229591109532048 0.428438023226534 0.817052642317894 0.625 30.3 30 3 abnormal ilium morphology 0.229591109532048 0.428438023226534 0.817052642317894 0.625 30.3 30 3 stomach epithelial hyperplasia 0.229591109532048 0.428438023226534 0.817052642317894 0.625 30.3 30 3 choroidal neovascularization 0.229591109532048 0.428438023226534 0.817052642317894 0.625 30.3 30 3 increased pulmonary ventilation 0.229591109532048 0.428438023226534 0.817052642317894 0.625 30.3 30 3 abnormal corneocyte envelope morphology 0.229591109532048 0.428438023226534 0.817052642317894 0.625 30.3 30 3 impaired behavioral response to alcohol 0.229591109532048 0.428438023226534 0.817052642317894 0.625 30.3 30 3 abnormal meiotic spindle morphology 0.229591109532048 0.428438023226534 0.817052642317894 0.625 30.3 30 3 abnormal base-excision repair 0.229591109532048 0.428438023226534 0.817052642317894 0.625 30.3 30 3 abnormal frontonasal prominence morphology 0.229591109532048 0.428438023226534 0.817052642317894 0.625 30.3 30 3 abnormal lateral plate mesoderm morphology 0.229591109532048 0.428438023226534 0.817052642317894 0.625 30.3 30 3 ostium secundum atrial septal defect 0.229591109532048 0.428438023226534 0.817052642317894 0.625 30.3 30 3 abnormal stomach position or orientation 0.229591109532048 0.428438023226534 0.817052642317894 0.625 30.3 30 3 absent ureteric bud 0.229591109532048 0.428438023226534 0.817052642317894 0.625 30.3 30 3 abnormal macrophage activation involved in immune response 0.229591109532048 0.428438023226534 0.817052642317894 0.625 30.3 30 3 embryo cyst 0.229591109532048 0.428438023226534 0.817052642317894 0.625 30.3 30 3 increased mammary gland apoptosis 0.229591109532048 0.428438023226534 0.817052642317894 0.625 30.3 30 3 decreased white adipose tissue mass 0.229591109532048 0.428438023226534 0.817052642317894 0.625 30.3 30 3 decreased vascular endothelial cell proliferation 0.229591109532048 0.428438023226534 0.817052642317894 0.625 30.3 30 3 increased circulating insulin level 7.95168353235078e-07 1.66216914174139e-05 0.817052642317894 0.625 30.3 30 3 abnormal urine homeostasis 0.000119688637275857 0.0013380920684211 0.817052642317894 0.625 30.3 30 3 abnormal cardiovascular system morphology 0.00580677637489132 0.0330534467563894 0.817052642317894 0.625 30.3 30 3 abnormal foregut morphology 0.0462306707610804 0.160500758573883 0.817052642317894 0.625 30.3 30 3 abnormal vasodilation 0.0462306707610804 0.160500758573883 0.817052642317894 0.625 30.3 30 3 apnea 0.0462306707610804 0.160500758573883 0.817052642317894 0.625 30.3 30 3 abnormal tumor morphology 0.0462306707610804 0.160500758573883 0.817052642317894 0.625 30.3 30 3 hypopigmentation 0.0462306707610804 0.160500758573883 0.817052642317894 0.625 30.3 30 3 increased osteoclast cell number 0.00220147399021008 0.0154041253182773 0.81437378119554 0.622950819672131 30.3 30 3 abnormal coat/ hair morphology 0.00424845361496741 0.0254651285957384 0.813969424799714 0.622641509433962 30.3 30 3 abnormal pancreatic islet morphology 0.00424845361496741 0.0254651285957384 0.813969424799714 0.622641509433962 30.3 30 3 increased circulating corticosterone level 0.0082743450818179 0.0425256888244257 0.813421297240926 0.622222222222222 30.3 30 3 albuminuria 0.0082743450818179 0.0425256888244257 0.813421297240926 0.622222222222222 30.3 30 3 increased trabecular bone volume 0.0163197764863055 0.0718503433799733 0.812636141548608 0.621621621621622 30.3 30 3 absent long term depression 0.0327860482449057 0.127132182399381 0.811417796508805 0.620689655172414 30.3 30 3 increased retinal apoptosis 0.0327860482449057 0.127132182399381 0.811417796508805 0.620689655172414 30.3 30 3 increased circulating chloride level 0.00603053821439147 0.0337859545231954 0.810516221179351 0.62 30.3 30 3 decreased oocyte number 0.00603053821439147 0.0337859545231954 0.810516221179351 0.62 30.3 30 3 abnormal muscle morphology 0.0118009674646345 0.0573898466633005 0.809271188581533 0.619047619047619 30.3 30 3 trunk curl 0.0678349518767977 0.213729503221703 0.809271188581533 0.619047619047619 30.3 30 3 abnormal hematopoietic system physiology 0.0678349518767977 0.213729503221703 0.809271188581533 0.619047619047619 30.3 30 3 dry skin 0.0678349518767977 0.213729503221703 0.809271188581533 0.619047619047619 30.3 30 3 increased bone ossification 0.0678349518767977 0.213729503221703 0.809271188581533 0.619047619047619 30.3 30 3 decreased vocalization 0.0678349518767977 0.213729503221703 0.809271188581533 0.619047619047619 30.3 30 3 abnormal hair follicle morphology 0.00228602064735458 0.0157999837632098 0.809271188581533 0.619047619047619 30.3 30 3 increased circulating calcium level 0.00440562304442247 0.0261863496368002 0.808139340765336 0.618181818181818 30.3 30 3 abnormal retinal photoreceptor morphology 0.0234319297091858 0.0979612187421844 0.807440258290625 0.617647058823529 30.3 30 3 increased exploration in new environment 0.000650329188582339 0.00568609439929198 0.806965572659649 0.617283950617284 30.3 30 3 abnormal T-helper 1 physiology 0.00856448115158303 0.0438808380320552 0.806622183054262 0.617021276595745 30.3 30 3 increased T cell proliferation 0.000100092142099385 0.00114473196998722 0.806362233913735 0.616822429906542 30.3 30 3 increased urine protein level 0.000911786036897082 0.00751015816815064 0.80448260166685 0.615384615384615 30.3 30 3 abnormal skin condition 0.00623457935042308 0.0348898000768896 0.80448260166685 0.615384615384615 30.3 30 3 abnormal stomach morphology 0.0475567030635361 0.16464481401607 0.80448260166685 0.615384615384615 30.3 30 3 increased susceptibility to otitis media 0.0475567030635361 0.16464481401607 0.80448260166685 0.615384615384615 30.3 30 3 abnormal nerve conduction 0.0475567030635361 0.16464481401607 0.80448260166685 0.615384615384615 30.3 30 3 short premaxilla 0.148328932724267 0.349636139261802 0.80448260166685 0.615384615384615 30.3 30 3 absent teeth 0.148328932724267 0.349636139261802 0.80448260166685 0.615384615384615 30.3 30 3 small trigeminal ganglion 0.148328932724267 0.349636139261802 0.80448260166685 0.615384615384615 30.3 30 3 dystrophic cardiac calcinosis 0.148328932724267 0.349636139261802 0.80448260166685 0.615384615384615 30.3 30 3 increased synaptic depression 0.148328932724267 0.349636139261802 0.80448260166685 0.615384615384615 30.3 30 3 tracheoesophageal fistula 0.148328932724267 0.349636139261802 0.80448260166685 0.615384615384615 30.3 30 3 abnormal afterhyperpolarization 0.148328932724267 0.349636139261802 0.80448260166685 0.615384615384615 30.3 30 3 muscle fatigue 0.148328932724267 0.349636139261802 0.80448260166685 0.615384615384615 30.3 30 3 small interparietal bone 0.148328932724267 0.349636139261802 0.80448260166685 0.615384615384615 30.3 30 3 abnormal exocrine pancreas morphology 0.148328932724267 0.349636139261802 0.80448260166685 0.615384615384615 30.3 30 3 small pituitary gland 0.148328932724267 0.349636139261802 0.80448260166685 0.615384615384615 30.3 30 3 orthokeratosis 0.148328932724267 0.349636139261802 0.80448260166685 0.615384615384615 30.3 30 3 abnormal aorta tunica media morphology 0.148328932724267 0.349636139261802 0.80448260166685 0.615384615384615 30.3 30 3 abnormal renal glomerulus morphology 0.000103601999820164 0.00117675787466967 0.803560029875947 0.614678899082569 30.3 30 3 abnormal blood homeostasis 7.68906169204645e-05 0.000902195328253091 0.802718385435124 0.614035087719298 30.3 30 3 abnormal myelopoiesis 0.0121693364367176 0.0591234851295607 0.802197139730296 0.613636363636364 30.3 30 3 increased eosinophil cell number 0.00332835056580002 0.0208021910362501 0.801238720208516 0.612903225806452 30.3 30 3 abnormal retinal photoreceptor layer morphology 0.0337020630201311 0.130379287344597 0.801238720208516 0.612903225806452 30.3 30 3 abnormal T cell proliferation 0.0337020630201311 0.130379287344597 0.801238720208516 0.612903225806452 30.3 30 3 small testis 1.50457642333794e-09 5.463699055552e-08 0.800474762618691 0.61231884057971 30.3 30 3 circling 0.000694017498237601 0.00599433516272928 0.799750351068809 0.611764705882353 30.3 30 3 abnormal small intestine morphology 0.00641962952642712 0.035844732765404 0.798895916933052 0.611111111111111 30.3 30 3 short radius 0.0240733068803795 0.100558103887396 0.798895916933052 0.611111111111111 30.3 30 3 abnormal radius morphology 0.100132828727667 0.268478521893931 0.798895916933052 0.611111111111111 30.3 30 3 abnormal iron level 0.100132828727667 0.268478521893931 0.798895916933052 0.611111111111111 30.3 30 3 abnormal thyroid cartilage morphology 0.100132828727667 0.268478521893931 0.798895916933052 0.611111111111111 30.3 30 3 abnormal thymus medulla morphology 0.100132828727667 0.268478521893931 0.798895916933052 0.611111111111111 30.3 30 3 abnormal redox activity 0.100132828727667 0.268478521893931 0.798895916933052 0.611111111111111 30.3 30 3 decreased heart rate variability 0.100132828727667 0.268478521893931 0.798895916933052 0.611111111111111 30.3 30 3 abnormal macrophage chemotaxis 0.100132828727667 0.268478521893931 0.798895916933052 0.611111111111111 30.3 30 3 decreased fluid intake 0.100132828727667 0.268478521893931 0.798895916933052 0.611111111111111 30.3 30 3 polyuria 0.00131652118919911 0.0101231729772266 0.797952710419554 0.61038961038961 30.3 30 3 abnormal colon morphology 0.00468270601413087 0.0278000744872328 0.797664952500182 0.610169491525424 30.3 30 3 increased circulating glucose level 1.79533251771228e-05 0.000255193693589102 0.79735066370881 0.609929078014184 30.3 30 3 abnormal mammary gland development 0.0173001089557925 0.0758308740573282 0.797124529090629 0.609756097560976 30.3 30 3 fragile skeleton 0.0692146589200515 0.217166889005187 0.795738225561775 0.608695652173913 30.3 30 3 conjunctivitis 0.0692146589200515 0.217166889005187 0.795738225561775 0.608695652173913 30.3 30 3 abnormal B cell morphology 0.0692146589200515 0.217166889005187 0.795738225561775 0.608695652173913 30.3 30 3 abnormal lens development 0.0692146589200515 0.217166889005187 0.795738225561775 0.608695652173913 30.3 30 3 liver inflammation 8.42010674171829e-05 0.00097645760000113 0.795264571856084 0.608333333333333 30.3 30 3 increased kidney weight 0.0090562407425611 0.0461627025555753 0.794623746254266 0.607843137254902 30.3 30 3 failure of blastocyst to hatch from the zona pellucida 0.0485662985034542 0.165039163288719 0.793708281108812 0.607142857142857 30.3 30 3 increased bone resorption 0.0485662985034542 0.165039163288719 0.793708281108812 0.607142857142857 30.3 30 3 corneal vascularization 0.0485662985034542 0.165039163288719 0.793708281108812 0.607142857142857 30.3 30 3 decreased neutrophil cell number 0.000116706067756014 0.00131063811983334 0.793309232199255 0.606837606837607 30.3 30 3 abnormal maternal nurturing 0.00480337099547406 0.0283809628295528 0.792942892216711 0.60655737704918 30.3 30 3 head tossing 0.0344355792245283 0.130486621018159 0.792293471338564 0.606060606060606 30.3 30 3 abnormal retinal outer nuclear layer morphology 0.0246055388720186 0.101587183309786 0.791250979928908 0.605263157894737 30.3 30 3 abnormal compact bone morphology 0.0246055388720186 0.101587183309786 0.791250979928908 0.605263157894737 30.3 30 3 impaired branching involved in ureteric bud morphogenesis 0.0246055388720186 0.101587183309786 0.791250979928908 0.605263157894737 30.3 30 3 hyporesponsive to tactile stimuli 0.0246055388720186 0.101587183309786 0.791250979928908 0.605263157894737 30.3 30 3 increased circulating creatinine level 0.00102046565117219 0.00827555377513967 0.790450928381963 0.604651162790698 30.3 30 3 decreased oxygen consumption 0.0176865995196614 0.0774567188471085 0.790450928381963 0.604651162790698 30.3 30 3 abnormal kidney physiology 0.0127736094949545 0.0613404510013503 0.789817554240631 0.604166666666667 30.3 30 3 abnormal phalanx morphology 0.0127736094949545 0.0613404510013503 0.789817554240631 0.604166666666667 30.3 30 3 cochlear ganglion degeneration 0.0067359928031896 0.0367678767706968 0.78887841327245 0.603448275862069 30.3 30 3 increased sensitivity to induced morbidity/mortality 2.51810138120605e-06 4.54291527617091e-05 0.788633419976402 0.603260869565217 30.3 30 3 increased liver weight 0.00104381858871531 0.00837580238525591 0.787341637142698 0.602272727272727 30.3 30 3 small kidney 0.00104381858871531 0.00837580238525591 0.787341637142698 0.602272727272727 30.3 30 3 abnormal T-helper 2 physiology 0.00944063924943422 0.0479256941489135 0.784370536625179 0.6 30.3 30 3 abnormal action potential 0.0036640656442306 0.0225603051733258 0.784370536625179 0.6 30.3 30 3 epidermal hyperplasia 0.0068690082764136 0.0367678767706968 0.784370536625179 0.6 30.3 30 3 abnormal autopod morphology 0.0180118234690672 0.0788116286355403 0.784370536625179 0.6 30.3 30 3 abnormal intestinal goblet cell morphology 0.0350098581295972 0.130486621018159 0.784370536625179 0.6 30.3 30 3 gastrointestinal hemorrhage 0.0493094142861464 0.167221769647974 0.784370536625179 0.6 30.3 30 3 arrested T cell differentiation 0.0493094142861464 0.167221769647974 0.784370536625179 0.6 30.3 30 3 interdigital webbing 0.148920397808193 0.349636139261802 0.784370536625179 0.6 30.3 30 3 decreased salivation 0.148920397808193 0.349636139261802 0.784370536625179 0.6 30.3 30 3 vagina atresia 0.148920397808193 0.349636139261802 0.784370536625179 0.6 30.3 30 3 abnormal cricoid cartilage morphology 0.148920397808193 0.349636139261802 0.784370536625179 0.6 30.3 30 3 abnormal bronchus morphology 0.148920397808193 0.349636139261802 0.784370536625179 0.6 30.3 30 3 increased alcohol consumption 0.148920397808193 0.349636139261802 0.784370536625179 0.6 30.3 30 3 decreased aggression towards males 0.148920397808193 0.349636139261802 0.784370536625179 0.6 30.3 30 3 abnormal zygomatic bone morphology 0.148920397808193 0.349636139261802 0.784370536625179 0.6 30.3 30 3 immune system phenotype 0.148920397808193 0.349636139261802 0.784370536625179 0.6 30.3 30 3 abnormal secondary palate development 0.148920397808193 0.349636139261802 0.784370536625179 0.6 30.3 30 3 liver vascular congestion 0.148920397808193 0.349636139261802 0.784370536625179 0.6 30.3 30 3 ostium primum atrial septal defect 0.148920397808193 0.349636139261802 0.784370536625179 0.6 30.3 30 3 decreased trabecular bone mass 0.148920397808193 0.349636139261802 0.784370536625179 0.6 30.3 30 3 abnormal kidney morphology 6.53474242040745e-06 0.000104199819043356 0.784370536625178 0.6 30.3 30 3 increased body length 0.0130156569657863 0.0624425201589072 0.784370536625178 0.6 30.3 30 3 abnormal pancreatic beta cell morphology 0.0250400282342418 0.103295307185201 0.784370536625178 0.6 30.3 30 3 abnormal inner ear vestibule morphology 0.0701323912614077 0.219439400330505 0.784370536625178 0.6 30.3 30 3 ruffled hair 0.0701323912614077 0.219439400330505 0.784370536625178 0.6 30.3 30 3 abnormal cell proliferation 0.101131537461501 0.269171929595029 0.784370536625178 0.6 30.3 30 3 increased urine glucose level 0.101131537461501 0.269171929595029 0.784370536625178 0.6 30.3 30 3 abnormal dopamine level 0.101131537461501 0.269171929595029 0.784370536625178 0.6 30.3 30 3 abnormal Peyer's patch T cell area morphology 0.101131537461501 0.269171929595029 0.784370536625178 0.6 30.3 30 3 absent placental labyrinth 0.101131537461501 0.269171929595029 0.784370536625178 0.6 30.3 30 3 enhanced behavioral response to xenobiotic 0.101131537461501 0.269171929595029 0.784370536625178 0.6 30.3 30 3 abnormal heart electrocardiography waveform feature 0.101131537461501 0.269171929595029 0.784370536625178 0.6 30.3 30 3 absent palatine bone horizontal plate 0.227393269930933 0.428438023226534 0.784370536625178 0.6 30.3 30 3 abnormal prostate gland epithelium morphology 0.227393269930933 0.428438023226534 0.784370536625178 0.6 30.3 30 3 abnormal gland morphology 0.227393269930933 0.428438023226534 0.784370536625178 0.6 30.3 30 3 abnormal neuron specification 0.227393269930933 0.428438023226534 0.784370536625178 0.6 30.3 30 3 primary sex reversal 0.227393269930933 0.428438023226534 0.784370536625178 0.6 30.3 30 3 rickets 0.227393269930933 0.428438023226534 0.784370536625178 0.6 30.3 30 3 abnormal scala media morphology 0.227393269930933 0.428438023226534 0.784370536625178 0.6 30.3 30 3 aneurysm 0.227393269930933 0.428438023226534 0.784370536625178 0.6 30.3 30 3 abnormal glial cell physiology 0.227393269930933 0.428438023226534 0.784370536625178 0.6 30.3 30 3 absent CD4-positive, alpha beta T cells 0.227393269930933 0.428438023226534 0.784370536625178 0.6 30.3 30 3 abnormal submandibular gland morphology 0.227393269930933 0.428438023226534 0.784370536625178 0.6 30.3 30 3 increased atrioventricular cushion size 0.227393269930933 0.428438023226534 0.784370536625178 0.6 30.3 30 3 increased left ventricle diastolic pressure 0.227393269930933 0.428438023226534 0.784370536625178 0.6 30.3 30 3 increased defecation amount 0.227393269930933 0.428438023226534 0.784370536625178 0.6 30.3 30 3 absent pharyngeal arches 0.227393269930933 0.428438023226534 0.784370536625178 0.6 30.3 30 3 abnormal ear physiology 0.227393269930933 0.428438023226534 0.784370536625178 0.6 30.3 30 3 abnormal placental transport 0.227393269930933 0.428438023226534 0.784370536625178 0.6 30.3 30 3 absent coat pigmentation 0.227393269930933 0.428438023226534 0.784370536625178 0.6 30.3 30 3 ascites 0.227393269930933 0.428438023226534 0.784370536625178 0.6 30.3 30 3 vascular smooth muscle hyperplasia 0.227393269930933 0.428438023226534 0.784370536625178 0.6 30.3 30 3 absent inguinal lymph nodes 0.227393269930933 0.428438023226534 0.784370536625178 0.6 30.3 30 3 abnormal cerebellar granule cell migration 0.227393269930933 0.428438023226534 0.784370536625178 0.6 30.3 30 3 abnormal retinal blood vessel pattern 0.227393269930933 0.428438023226534 0.784370536625178 0.6 30.3 30 3 acanthocytosis 0.227393269930933 0.428438023226534 0.784370536625178 0.6 30.3 30 3 increased T-helper 17 cell number 0.227393269930933 0.428438023226534 0.784370536625178 0.6 30.3 30 3 increased kidney iron level 0.227393269930933 0.428438023226534 0.784370536625178 0.6 30.3 30 3 fusion of atlas and odontoid process 0.227393269930933 0.428438023226534 0.784370536625178 0.6 30.3 30 3 increased compact bone area 0.227393269930933 0.428438023226534 0.784370536625178 0.6 30.3 30 3 abnormal circadian temperature homeostasis 0.227393269930933 0.428438023226534 0.784370536625178 0.6 30.3 30 3 abnormal femur morphology 0.00509917594827766 0.0298537171647943 0.780468195646944 0.597014925373134 30.3 30 3 absent corpus luteum 0.0132215504166695 0.0633691843188159 0.779342520364761 0.596153846153846 30.3 30 3 abnormal vibrissa morphology 0.0253870817369072 0.104640208484767 0.77814537363609 0.595238095238095 30.3 30 3 increased insulin secretion 0.0354451514583549 0.131010125189685 0.777304135394321 0.594594594594595 30.3 30 3 increased body weight 9.44537633468274e-07 1.93087773390919e-05 0.776200010202 0.59375 30.3 30 3 decreased eosinophil cell number 0.00708903309605927 0.0377601066947483 0.776200010202 0.59375 30.3 30 3 abnormal heart atrium morphology 0.0498274997533445 0.168404763092995 0.776200010202 0.59375 30.3 30 3 increased bone mineral density 0.000458441954170204 0.00424720432401632 0.77511542704848 0.592920353982301 30.3 30 3 abnormal type II pneumocyte morphology 0.070677896629552 0.220659927364652 0.774686949753263 0.592592592592593 30.3 30 3 abnormal single cell response 0.070677896629552 0.220659927364652 0.774686949753263 0.592592592592593 30.3 30 3 abnormal epidermis stratum corneum morphology 0.018499693975962 0.0802111507317007 0.773698828643884 0.591836734693878 30.3 30 3 abnormal craniofacial development 0.018499693975962 0.0802111507317007 0.773698828643884 0.591836734693878 30.3 30 3 increased fluid intake 0.018499693975962 0.0802111507317007 0.773698828643884 0.591836734693878 30.3 30 3 abnormal CD4-positive, alpha-beta T cell physiology 0.00524600908354614 0.0306325060923029 0.773323064278345 0.591549295774648 30.3 30 3 abnormal tail morphology 0.00717775021058785 0.0381917725108819 0.7724861345551 0.590909090909091 30.3 30 3 abnormal long bone epiphysis morphology 0.101500812044276 0.269171929595029 0.7724861345551 0.590909090909091 30.3 30 3 abnormal facial nerve morphology 0.101500812044276 0.269171929595029 0.7724861345551 0.590909090909091 30.3 30 3 abnormal oogenesis 0.101500812044276 0.269171929595029 0.7724861345551 0.590909090909091 30.3 30 3 parakeratosis 0.101500812044276 0.269171929595029 0.7724861345551 0.590909090909091 30.3 30 3 abnormal retinal outer plexiform layer morphology 0.101500812044276 0.269171929595029 0.7724861345551 0.590909090909091 30.3 30 3 rough coat 0.101500812044276 0.269171929595029 0.7724861345551 0.590909090909091 30.3 30 3 abnormal lens fiber morphology 0.0357590782954534 0.131974343115638 0.770962493264064 0.58974358974359 30.3 30 3 decreased trabecular bone volume 0.0357590782954534 0.131974343115638 0.770962493264064 0.58974358974359 30.3 30 3 increased inflammatory response 0.00156397975986326 0.0116304922351565 0.770609650017719 0.589473684210526 30.3 30 3 abnormal seminal vesicle morphology 0.01353572698769 0.0646880324339651 0.770363919899729 0.589285714285714 30.3 30 3 lung inflammation 0.000196229270528625 0.00207269770887455 0.768990722181548 0.588235294117647 30.3 30 3 lung hemorrhage 0.0501550785321607 0.169281896674016 0.768990722181548 0.588235294117647 30.3 30 3 increased width of hypertrophic chondrocyte zone 0.0501550785321607 0.169281896674016 0.768990722181548 0.588235294117647 30.3 30 3 abnormal urinary bladder morphology 0.148440063941205 0.349636139261802 0.768990722181548 0.588235294117647 30.3 30 3 abnormal touch/ nociception 0.148440063941205 0.349636139261802 0.768990722181548 0.588235294117647 30.3 30 3 nephrocalcinosis 0.148440063941205 0.349636139261802 0.768990722181548 0.588235294117647 30.3 30 3 increased hepatoma incidence 0.148440063941205 0.349636139261802 0.768990722181548 0.588235294117647 30.3 30 3 common atrium 0.148440063941205 0.349636139261802 0.768990722181548 0.588235294117647 30.3 30 3 abnormal thrombosis 0.0186719658561081 0.0804965599082651 0.768990722181548 0.588235294117647 30.3 30 3 skin lesions 0.00993744892421936 0.0501916836527831 0.767770101987609 0.587301587301587 30.3 30 3 abnormal lymphocyte physiology 0.0258550574110672 0.106480886274884 0.767319003220283 0.58695652173913 30.3 30 3 abnormal middle ear morphology 0.0709216530363977 0.220659927364652 0.766339030036094 0.586206896551724 30.3 30 3 short sternum 0.0709216530363977 0.220659927364652 0.766339030036094 0.586206896551724 30.3 30 3 abnormal CD8-positive, alpha-beta T cell physiology 0.0709216530363977 0.220659927364652 0.766339030036094 0.586206896551724 30.3 30 3 dehydration 0.00731671284069694 0.0384742957630614 0.765695047657912 0.585714285714286 30.3 30 3 scaly skin 0.0359669730979348 0.132544956416464 0.765239547927003 0.585365853658537 30.3 30 3 short ulna 0.0359669730979348 0.132544956416464 0.765239547927003 0.585365853658537 30.3 30 3 abnormal kidney development 0.0137362749023817 0.0655834622258628 0.762582466163368 0.583333333333333 30.3 30 3 abnormal epidermis stratum granulosum morphology 0.0503210298785016 0.169382356999692 0.762582466163368 0.583333333333333 30.3 30 3 renal hypoplasia 0.0503210298785016 0.169382356999692 0.762582466163368 0.583333333333333 30.3 30 3 abnormal adrenal gland morphology 0.101392242342611 0.269171929595029 0.762582466163368 0.583333333333333 30.3 30 3 prolonged QT interval 0.101392242342611 0.269171929595029 0.762582466163368 0.583333333333333 30.3 30 3 decreased ovulation rate 0.101392242342611 0.269171929595029 0.762582466163368 0.583333333333333 30.3 30 3 ear inflammation 0.22360733329811 0.428438023226534 0.762582466163368 0.583333333333333 30.3 30 3 increased papilloma incidence 0.22360733329811 0.428438023226534 0.762582466163368 0.583333333333333 30.3 30 3 small thyroid gland 0.22360733329811 0.428438023226534 0.762582466163368 0.583333333333333 30.3 30 3 abnormal alisphenoid bone morphology 0.22360733329811 0.428438023226534 0.762582466163368 0.583333333333333 30.3 30 3 impaired sperm capacitation 0.22360733329811 0.428438023226534 0.762582466163368 0.583333333333333 30.3 30 3 vestibular saccular macula degeneration 0.22360733329811 0.428438023226534 0.762582466163368 0.583333333333333 30.3 30 3 stria vascularis degeneration 0.22360733329811 0.428438023226534 0.762582466163368 0.583333333333333 30.3 30 3 abnormal B cell proliferation 0.22360733329811 0.428438023226534 0.762582466163368 0.583333333333333 30.3 30 3 abnormal anogenital distance 0.22360733329811 0.428438023226534 0.762582466163368 0.583333333333333 30.3 30 3 abnormal amacrine cell morphology 0.22360733329811 0.428438023226534 0.762582466163368 0.583333333333333 30.3 30 3 abnormal patella morphology 0.22360733329811 0.428438023226534 0.762582466163368 0.583333333333333 30.3 30 3 decreased renal glomerular filtration rate 0.22360733329811 0.428438023226534 0.762582466163368 0.583333333333333 30.3 30 3 hydrometra 0.22360733329811 0.428438023226534 0.762582466163368 0.583333333333333 30.3 30 3 decreased oligodendrocyte number 0.22360733329811 0.428438023226534 0.762582466163368 0.583333333333333 30.3 30 3 decreased prostaglandin level 0.22360733329811 0.428438023226534 0.762582466163368 0.583333333333333 30.3 30 3 abnormal aorta elastic tissue morphology 0.22360733329811 0.428438023226534 0.762582466163368 0.583333333333333 30.3 30 3 maternal effect 0.0100729072188058 0.0505678238280107 0.76095649075577 0.582089552238806 30.3 30 3 abnormal male reproductive system morphology 0.0360821959275264 0.13268206473808 0.760048969598041 0.581395348837209 30.3 30 3 absent mature ovarian follicles 0.0709195929621678 0.220659927364652 0.759068261250173 0.580645161290323 30.3 30 3 abnormal CD8-positive, alpha beta T cell morphology 0.0709195929621678 0.220659927364652 0.759068261250173 0.580645161290323 30.3 30 3 abnormal coat appearance 0.0101169250412579 0.0507376029034861 0.757845929106453 0.579710144927536 30.3 30 3 enlarged adrenal glands 0.147233665326887 0.349636139261802 0.75684876341026 0.578947368421053 30.3 30 3 decreased chemically-elicited antinociception 0.147233665326887 0.349636139261802 0.75684876341026 0.578947368421053 30.3 30 3 abnormal neural crest cell migration 0.147233665326887 0.349636139261802 0.75684876341026 0.578947368421053 30.3 30 3 osteoarthritis 0.147233665326887 0.349636139261802 0.75684876341026 0.578947368421053 30.3 30 3 abnormal photoreceptor inner segment morphology 0.147233665326887 0.349636139261802 0.75684876341026 0.578947368421053 30.3 30 3 abnormal behavioral response to xenobiotic 0.147233665326887 0.349636139261802 0.75684876341026 0.578947368421053 30.3 30 3 decreased susceptibility to weight gain 0.147233665326887 0.349636139261802 0.75684876341026 0.578947368421053 30.3 30 3 abnormal ovarian follicle morphology 0.0361164036094921 0.13268206473808 0.755319776009431 0.577777777777778 30.3 30 3 decreased IgA level 0.0261043505462515 0.107418646788752 0.754202439062672 0.576923076923077 30.3 30 3 abnormal kidney cortex morphology 0.100917420622142 0.269171929595029 0.754202439062672 0.576923076923077 30.3 30 3 increased leukemia incidence 0.100917420622142 0.269171929595029 0.754202439062672 0.576923076923077 30.3 30 3 decreased circulating glycerol level 0.100917420622142 0.269171929595029 0.754202439062672 0.576923076923077 30.3 30 3 abnormal erythrocyte osmotic lysis 0.100917420622142 0.269171929595029 0.754202439062672 0.576923076923077 30.3 30 3 impaired swimming 0.0138619797355957 0.0657968031712751 0.752678797771636 0.575757575757576 30.3 30 3 single kidney 0.0707165347567378 0.220659927364652 0.752678797771636 0.575757575757576 30.3 30 3 decreased circulating phosphate level 0.050261322495916 0.169382356999692 0.751688430932463 0.575 30.3 30 3 abnormal female reproductive system morphology 0.050261322495916 0.169382356999692 0.751688430932463 0.575 30.3 30 3 decreased T cell proliferation 0.000381897663849791 0.00362096423817257 0.750805130778606 0.574324324324324 30.3 30 3 abnormal trabecular bone morphology 0.00166515283025746 0.0122465969190299 0.747019558690646 0.571428571428571 30.3 30 3 arrest of spermatogenesis 0.00747641915419725 0.0391528266232961 0.747019558690646 0.571428571428571 30.3 30 3 increased food intake 0.00747641915419725 0.0391528266232961 0.747019558690646 0.571428571428571 30.3 30 3 reddish skin 0.100160027464349 0.268478521893931 0.747019558690646 0.571428571428571 30.3 30 3 abnormal respiration 0.100160027464349 0.268478521893931 0.747019558690646 0.571428571428571 30.3 30 3 abnormal anxiety-related response 0.145526984907771 0.349473744651166 0.747019558690646 0.571428571428571 30.3 30 3 abnormal spleen periarteriolar lymphoid sheath morphology 0.219012918612973 0.428438023226534 0.747019558690646 0.571428571428571 30.3 30 3 abnormal vascular endothelial cell migration 0.219012918612973 0.428438023226534 0.747019558690646 0.571428571428571 30.3 30 3 enlarged stomach 0.219012918612973 0.428438023226534 0.747019558690646 0.571428571428571 30.3 30 3 abnormal positive T cell selection 0.219012918612973 0.428438023226534 0.747019558690646 0.571428571428571 30.3 30 3 increased B-1 B cell number 0.219012918612973 0.428438023226534 0.747019558690646 0.571428571428571 30.3 30 3 impaired adaptive thermogenesis 0.0703487057355785 0.219977882485546 0.747019558690646 0.571428571428571 30.3 30 3 abnormal dendritic cell physiology 0.00301867212078152 0.0196312337266511 0.745274185889967 0.570093457943925 30.3 30 3 abnormal response to infection 0.0101434237860325 0.0508192682130028 0.744655572745423 0.569620253164557 30.3 30 3 abnormal photoreceptor outer segment morphology 0.0498009017159062 0.168404763092995 0.742775129379904 0.568181818181818 30.3 30 3 decreased sensitivity to induced morbidity/mortality 0.0498009017159062 0.168404763092995 0.742775129379904 0.568181818181818 30.3 30 3 skin inflammation 0.0698456203049442 0.218817355804218 0.741972129240034 0.567567567567568 30.3 30 3 abnormal humerus morphology 0.0698456203049442 0.218817355804218 0.741972129240034 0.567567567567568 30.3 30 3 abnormal spleen marginal zone morphology 0.0991838114021117 0.267301983599949 0.740794395701557 0.566666666666667 30.3 30 3 abnormal food intake 0.0187367817470221 0.0807060512479956 0.738899780878791 0.565217391304348 30.3 30 3 abnormal inner ear morphology 0.0494561536674448 0.167491058199822 0.738899780878791 0.565217391304348 30.3 30 3 delayed wound healing 0.0494561536674448 0.167491058199822 0.738899780878791 0.565217391304348 30.3 30 3 abnormal carpal bone morphology 0.143472811105769 0.346325684255798 0.738899780878791 0.565217391304348 30.3 30 3 abnormal circulating insulin level 0.143472811105769 0.346325684255798 0.738899780878791 0.565217391304348 30.3 30 3 hypotension 0.143472811105769 0.346325684255798 0.738899780878791 0.565217391304348 30.3 30 3 abnormal sacral vertebrae morphology 0.143472811105769 0.346325684255798 0.738899780878791 0.565217391304348 30.3 30 3 increased susceptibility to age related obesity 0.143472811105769 0.346325684255798 0.738899780878791 0.565217391304348 30.3 30 3 abnormal Wolffian duct morphology 0.143472811105769 0.346325684255798 0.738899780878791 0.565217391304348 30.3 30 3 acanthosis 0.0692314946657741 0.217166889005187 0.737442384861279 0.564102564102564 30.3 30 3 increased autoantibody level 0.0692314946657741 0.217166889005187 0.737442384861279 0.564102564102564 30.3 30 3 abnormal lymph node morphology 0.0490500587462336 0.166569312124582 0.735347378086105 0.5625 30.3 30 3 abnormal depression-related behavior 0.0980379985163686 0.265048132438272 0.735347378086105 0.5625 30.3 30 3 abnormal serotonin level 0.0980379985163686 0.265048132438272 0.735347378086105 0.5625 30.3 30 3 decreased mast cell number 0.21401118238032 0.428438023226534 0.735347378086105 0.5625 30.3 30 3 mixed cellular infiltration to dermis 0.21401118238032 0.428438023226534 0.735347378086105 0.5625 30.3 30 3 decreased cochlear coiling 0.21401118238032 0.428438023226534 0.735347378086105 0.5625 30.3 30 3 sepsis 0.21401118238032 0.428438023226534 0.735347378086105 0.5625 30.3 30 3 abnormal intestinal lipid absorption 0.21401118238032 0.428438023226534 0.735347378086105 0.5625 30.3 30 3 abnormal cholesterol homeostasis 0.0685263245044476 0.215771180006093 0.733354566763378 0.560975609756098 30.3 30 3 abnormal cochlear outer hair cell morphology 0.141177507355051 0.342140030506066 0.732079167516833 0.56 30.3 30 3 abnormal vertebrae development 0.141177507355051 0.342140030506066 0.732079167516833 0.56 30.3 30 3 decreased cytotoxic T cell cytolysis 0.0967610459745361 0.262622042402246 0.73054118607247 0.558823529411765 30.3 30 3 decreased IgG level 0.00528835685766004 0.030839801628372 0.730194793855271 0.558558558558559 30.3 30 3 abnormal hair growth 0.0480897206792742 0.164900716649211 0.729062357760583 0.557692307692308 30.3 30 3 increased double-negative T cell number 0.0344684169092159 0.130486621018159 0.72865022528022 0.557377049180328 30.3 30 3 abnormal cochlea morphology 0.0475504209628555 0.16464481401607 0.726269015393684 0.555555555555556 30.3 30 3 abnormal trigeminal ganglion morphology 0.13871682561288 0.341810900160513 0.726269015393684 0.555555555555556 30.3 30 3 abnormal palate morphology 0.13871682561288 0.341810900160513 0.726269015393684 0.555555555555556 30.3 30 3 altered response to myocardial infarction 0.0669065243489238 0.211473925435766 0.726269015393684 0.555555555555556 30.3 30 3 abnormal uterus morphology 0.0953833005569251 0.259165439798308 0.726269015393684 0.555555555555556 30.3 30 3 head tilt 0.0953833005569251 0.259165439798308 0.726269015393684 0.555555555555556 30.3 30 3 abnormal white adipose tissue morphology 0.208824107958127 0.428438023226534 0.726269015393684 0.555555555555556 30.3 30 3 absent allantois 0.208824107958127 0.428438023226534 0.726269015393684 0.555555555555556 30.3 30 3 abnormal head movements 0.339922267128022 0.584974125559652 0.726269015393684 0.555555555555556 30.3 30 3 crypts of Lieberkuhn abscesses 0.339922267128022 0.584974125559652 0.726269015393684 0.555555555555556 30.3 30 3 renal tubular acidosis 0.339922267128022 0.584974125559652 0.726269015393684 0.555555555555556 30.3 30 3 abnormal urinary bladder urothelium morphology 0.339922267128022 0.584974125559652 0.726269015393684 0.555555555555556 30.3 30 3 deformed nails 0.339922267128022 0.584974125559652 0.726269015393684 0.555555555555556 30.3 30 3 absent parathyroid glands 0.339922267128022 0.584974125559652 0.726269015393684 0.555555555555556 30.3 30 3 absent enteric neurons 0.339922267128022 0.584974125559652 0.726269015393684 0.555555555555556 30.3 30 3 dilated uterus 0.339922267128022 0.584974125559652 0.726269015393684 0.555555555555556 30.3 30 3 abnormal vagina epithelium morphology 0.339922267128022 0.584974125559652 0.726269015393684 0.555555555555556 30.3 30 3 decreased level of surface class I molecules 0.339922267128022 0.584974125559652 0.726269015393684 0.555555555555556 30.3 30 3 abnormal thymus lobule morphology 0.339922267128022 0.584974125559652 0.726269015393684 0.555555555555556 30.3 30 3 abnormal postural reflex 0.339922267128022 0.584974125559652 0.726269015393684 0.555555555555556 30.3 30 3 decreased circulating bicarbonate level 0.339922267128022 0.584974125559652 0.726269015393684 0.555555555555556 30.3 30 3 absent posterior semicircular canal 0.339922267128022 0.584974125559652 0.726269015393684 0.555555555555556 30.3 30 3 biliary cyst 0.339922267128022 0.584974125559652 0.726269015393684 0.555555555555556 30.3 30 3 decreased susceptibility to induced choroidal neovascularization 0.339922267128022 0.584974125559652 0.726269015393684 0.555555555555556 30.3 30 3 abnormal bony labyrinth 0.339922267128022 0.584974125559652 0.726269015393684 0.555555555555556 30.3 30 3 abnormal stria vascularis vasculature morphology 0.339922267128022 0.584974125559652 0.726269015393684 0.555555555555556 30.3 30 3 abnormal CNS synapse formation 0.339922267128022 0.584974125559652 0.726269015393684 0.555555555555556 30.3 30 3 absent adrenal gland 0.339922267128022 0.584974125559652 0.726269015393684 0.555555555555556 30.3 30 3 abnormal pulmonary alveolar parenchyma morphology 0.339922267128022 0.584974125559652 0.726269015393684 0.555555555555556 30.3 30 3 decreased airway resistance 0.339922267128022 0.584974125559652 0.726269015393684 0.555555555555556 30.3 30 3 abnormal oxidative phosphorylation 0.339922267128022 0.584974125559652 0.726269015393684 0.555555555555556 30.3 30 3 reduced AMPA-mediated synaptic currents 0.339922267128022 0.584974125559652 0.726269015393684 0.555555555555556 30.3 30 3 increased core body temperature 0.339922267128022 0.584974125559652 0.726269015393684 0.555555555555556 30.3 30 3 decreased bone mineral density of femur 0.339922267128022 0.584974125559652 0.726269015393684 0.555555555555556 30.3 30 3 adipose tissue inflammation 0.339922267128022 0.584974125559652 0.726269015393684 0.555555555555556 30.3 30 3 decreased monocyte cell number 0.0337324192976352 0.130395327121783 0.724034341500165 0.553846153846154 30.3 30 3 increased neutrophil cell number 0.00269280182368646 0.0182765198810916 0.721260263563383 0.551724137931034 30.3 30 3 decreased granulocyte number 0.136145719067981 0.336141415564865 0.721260263563383 0.551724137931034 30.3 30 3 aphagia 0.136145719067981 0.336141415564865 0.721260263563383 0.551724137931034 30.3 30 3 abnormal respiratory system physiology 0.0650890420188116 0.207309848939557 0.720340288737409 0.551020408163265 30.3 30 3 decreased urine osmolality 0.0650890420188116 0.207309848939557 0.720340288737409 0.551020408163265 30.3 30 3 abnormal epidermal layer morphology 0.0329279613859968 0.127583027955868 0.71995363265113 0.550724637681159 30.3 30 3 head bobbing 0.0924172606511562 0.253180546112061 0.719006325239747 0.55 30.3 30 3 abnormal hair texture 0.203580710495692 0.427889326031293 0.719006325239747 0.55 30.3 30 3 abnormal fibula morphology 0.203580710495692 0.427889326031293 0.719006325239747 0.55 30.3 30 3 spleen atrophy 0.203580710495692 0.427889326031293 0.719006325239747 0.55 30.3 30 3 abnormal thymocyte activation 0.203580710495692 0.427889326031293 0.719006325239747 0.55 30.3 30 3 kidney atrophy 0.203580710495692 0.427889326031293 0.719006325239747 0.55 30.3 30 3 abnormal circadian rhythm 0.0892816902441872 0.247314258889104 0.713064124204708 0.545454545454545 30.3 30 3 abnormal epidermis stratum basale morphology 0.130823755027925 0.326809516580671 0.713064124204708 0.545454545454545 30.3 30 3 decreased systemic arterial blood pressure 0.130823755027925 0.326809516580671 0.713064124204708 0.545454545454545 30.3 30 3 diarrhea 0.130823755027925 0.326809516580671 0.713064124204708 0.545454545454545 30.3 30 3 decreased sensitivity to xenobiotic induced morbidity/mortality 0.130823755027925 0.326809516580671 0.713064124204708 0.545454545454545 30.3 30 3 abnormal tracheal cartilage morphology 0.198358392343964 0.417972470102169 0.713064124204708 0.545454545454545 30.3 30 3 abnormal circulating lipid level 0.198358392343964 0.417972470102169 0.713064124204708 0.545454545454545 30.3 30 3 abnormal basement membrane morphology 0.198358392343964 0.417972470102169 0.713064124204708 0.545454545454545 30.3 30 3 pulmonary vascular congestion 0.198358392343964 0.417972470102169 0.713064124204708 0.545454545454545 30.3 30 3 increased bone volume 0.198358392343964 0.417972470102169 0.713064124204708 0.545454545454545 30.3 30 3 abnormal ear position 0.324931230702462 0.584974125559652 0.713064124204708 0.545454545454545 30.3 30 3 increased mast cell number 0.324931230702462 0.584974125559652 0.713064124204708 0.545454545454545 30.3 30 3 social withdrawal 0.324931230702462 0.584974125559652 0.713064124204708 0.545454545454545 30.3 30 3 impaired myelopoiesis 0.324931230702462 0.584974125559652 0.713064124204708 0.545454545454545 30.3 30 3 focal hepatic necrosis 0.324931230702462 0.584974125559652 0.713064124204708 0.545454545454545 30.3 30 3 abnormal vestibular ganglion morphology 0.324931230702462 0.584974125559652 0.713064124204708 0.545454545454545 30.3 30 3 variable body spotting 0.324931230702462 0.584974125559652 0.713064124204708 0.545454545454545 30.3 30 3 allodynia 0.324931230702462 0.584974125559652 0.713064124204708 0.545454545454545 30.3 30 3 abnormal lymph circulation 0.324931230702462 0.584974125559652 0.713064124204708 0.545454545454545 30.3 30 3 pathological neovascularization 0.324931230702462 0.584974125559652 0.713064124204708 0.545454545454545 30.3 30 3 abnormal pituitary gland development 0.324931230702462 0.584974125559652 0.713064124204708 0.545454545454545 30.3 30 3 enlarged placenta 0.324931230702462 0.584974125559652 0.713064124204708 0.545454545454545 30.3 30 3 abnormal crista ampullaris neuroepithelium morphology 0.324931230702462 0.584974125559652 0.713064124204708 0.545454545454545 30.3 30 3 abnormal aorta smooth muscle morphology 0.324931230702462 0.584974125559652 0.713064124204708 0.545454545454545 30.3 30 3 decreased palatine bone horizontal plate size 0.324931230702462 0.584974125559652 0.713064124204708 0.545454545454545 30.3 30 3 decreased susceptibility to induced arthritis 0.061131430825956 0.196212173134923 0.710979141385396 0.543859649122807 30.3 30 3 abnormal immune system morphology 0.0876807751602078 0.243014961795005 0.710480558537299 0.543478260869565 30.3 30 3 abnormal sleep pattern 0.0876807751602078 0.243014961795005 0.710480558537299 0.543478260869565 30.3 30 3 abnormal humoral immune response 0.0154481688861844 0.0681335462843684 0.709668580756114 0.542857142857143 30.3 30 3 thick epidermis 0.0424801804233742 0.148830209581892 0.709668580756114 0.542857142857143 30.3 30 3 abnormal malleus morphology 0.193204392371319 0.407976168101575 0.708112290008842 0.541666666666667 30.3 30 3 abnormal osteoblast morphology 0.193204392371319 0.407976168101575 0.708112290008842 0.541666666666667 30.3 30 3 increased circulating total protein level 0.193204392371319 0.407976168101575 0.708112290008842 0.541666666666667 30.3 30 3 abnormal NK cell physiology 0.0590812174764925 0.190615471430318 0.70721933630139 0.540983606557377 30.3 30 3 increased brown adipose tissue amount 0.125427630265137 0.319019662867616 0.706640123085746 0.540540540540541 30.3 30 3 abnormal hindlimb morphology 0.0844552407066488 0.234466976850211 0.705933482962661 0.54 30.3 30 3 abnormal digestive system physiology 0.0844552407066488 0.234466976850211 0.705933482962661 0.54 30.3 30 3 abnormal cytokine secretion 0.00530043805457558 0.030839801628372 0.704575265583223 0.538961038961039 30.3 30 3 abnormal leukocyte migration 0.0828432099995447 0.233319511664255 0.703922276458493 0.538461538461538 30.3 30 3 abnormal ureter morphology 0.188147608543445 0.397804654697678 0.703922276458493 0.538461538461538 30.3 30 3 abnormal ocular fundus morphology 0.188147608543445 0.397804654697678 0.703922276458493 0.538461538461538 30.3 30 3 pulmonary edema 0.188147608543445 0.397804654697678 0.703922276458493 0.538461538461538 30.3 30 3 abnormal membranous labyrinth morphology 0.311432133967593 0.56941376938213 0.703922276458493 0.538461538461538 30.3 30 3 abnormal mast cell morphology 0.311432133967593 0.56941376938213 0.703922276458493 0.538461538461538 30.3 30 3 tight skin 0.311432133967593 0.56941376938213 0.703922276458493 0.538461538461538 30.3 30 3 abnormal digestion 0.311432133967593 0.56941376938213 0.703922276458493 0.538461538461538 30.3 30 3 abnormal otolith morphology 0.311432133967593 0.56941376938213 0.703922276458493 0.538461538461538 30.3 30 3 abnormal bile duct development 0.311432133967593 0.56941376938213 0.703922276458493 0.538461538461538 30.3 30 3 anal atresia 0.311432133967593 0.56941376938213 0.703922276458493 0.538461538461538 30.3 30 3 absent lateral semicircular canal 0.311432133967593 0.56941376938213 0.703922276458493 0.538461538461538 30.3 30 3 abnormal insulin secretion 0.311432133967593 0.56941376938213 0.703922276458493 0.538461538461538 30.3 30 3 abnormal vestibulocochlear ganglion morphology 0.311432133967593 0.56941376938213 0.703922276458493 0.538461538461538 30.3 30 3 decreased luteinizing hormone level 0.311432133967593 0.56941376938213 0.703922276458493 0.538461538461538 30.3 30 3 increased circulating ammonia level 0.311432133967593 0.56941376938213 0.703922276458493 0.538461538461538 30.3 30 3 hyperalgesia 0.311432133967593 0.56941376938213 0.703922276458493 0.538461538461538 30.3 30 3 abnormal hair follicle inner root sheath morphology 0.311432133967593 0.56941376938213 0.703922276458493 0.538461538461538 30.3 30 3 abnormal stria vascularis morphology 0.183205438861184 0.397654857194145 0.700330836272481 0.535714285714286 30.3 30 3 decreased inflammatory response 0.0377384251822106 0.137645649033356 0.700330836272481 0.535714285714286 30.3 30 3 impaired macrophage phagocytosis 0.117448792815336 0.299031598902915 0.699245052030198 0.534883720930233 30.3 30 3 decreased osteoclast cell number 0.114853308410202 0.293552390400128 0.697218254777937 0.533333333333333 30.3 30 3 abnormal eye physiology 0.0765004206133771 0.22997478717813 0.697218254777936 0.533333333333333 30.3 30 3 hyperpigmentation 0.29911865667558 0.550542107643732 0.697218254777936 0.533333333333333 30.3 30 3 abnormal seizure response to electrical stimulation 0.29911865667558 0.550542107643732 0.697218254777936 0.533333333333333 30.3 30 3 increased airway responsiveness 0.29911865667558 0.550542107643732 0.697218254777936 0.533333333333333 30.3 30 3 altered righting response 0.29911865667558 0.550542107643732 0.697218254777936 0.533333333333333 30.3 30 3 dilated ureter 0.29911865667558 0.550542107643732 0.697218254777936 0.533333333333333 30.3 30 3 abnormal rostral migratory stream morphology 0.29911865667558 0.550542107643732 0.697218254777936 0.533333333333333 30.3 30 3 abnormal Muller cell morphology 0.29911865667558 0.550542107643732 0.697218254777936 0.533333333333333 30.3 30 3 absent chorion 0.29911865667558 0.550542107643732 0.697218254777936 0.533333333333333 30.3 30 3 abnormal coronary vessel morphology 0.29911865667558 0.550542107643732 0.697218254777936 0.533333333333333 30.3 30 3 abnormal microglial cell activation 0.29911865667558 0.550542107643732 0.697218254777936 0.533333333333333 30.3 30 3 abnormal skin morphology 0.0719280441551124 0.223257525258274 0.693256787421244 0.53030303030303 30.3 30 3 abnormal oocyte morphology 0.169144302712988 0.395922514642376 0.692091649963393 0.529411764705882 30.3 30 3 distended urinary bladder 0.287778690624324 0.532032324732817 0.692091649963393 0.529411764705882 30.3 30 3 enlarged sebaceous gland 0.287778690624324 0.532032324732817 0.692091649963393 0.529411764705882 30.3 30 3 pancytopenia 0.287778690624324 0.532032324732817 0.692091649963393 0.529411764705882 30.3 30 3 abnormal tendon morphology 0.287778690624324 0.532032324732817 0.692091649963393 0.529411764705882 30.3 30 3 abnormal electroretinogram waveform feature 0.287778690624324 0.532032324732817 0.692091649963393 0.529411764705882 30.3 30 3 delayed heart development 0.287778690624324 0.532032324732817 0.692091649963393 0.529411764705882 30.3 30 3 abnormal reflex 0.164720146453949 0.385820493695101 0.689955564624 0.527777777777778 30.3 30 3 small seminiferous tubules 0.0661513859274873 0.209220054030038 0.688974120008603 0.527027027027027 30.3 30 3 abnormal T cell activation 0.0661513859274873 0.209220054030038 0.688974120008603 0.527027027027027 30.3 30 3 flaky skin 0.277257933103947 0.514302094404228 0.688044330372964 0.526315789473684 30.3 30 3 shiny skin 0.277257933103947 0.514302094404228 0.688044330372964 0.526315789473684 30.3 30 3 stereotypic behavior 0.277257933103947 0.514302094404228 0.688044330372964 0.526315789473684 30.3 30 3 decreased grooming behavior 0.277257933103947 0.514302094404228 0.688044330372964 0.526315789473684 30.3 30 3 abnormal ear morphology 0.277257933103947 0.514302094404228 0.688044330372964 0.526315789473684 30.3 30 3 oliguria 0.277257933103947 0.514302094404228 0.688044330372964 0.526315789473684 30.3 30 3 absent amnion 0.277257933103947 0.514302094404228 0.688044330372964 0.526315789473684 30.3 30 3 decreased liver glycogen level 0.277257933103947 0.514302094404228 0.688044330372964 0.526315789473684 30.3 30 3 increased susceptibility to weight loss 0.156260027550444 0.366349499087399 0.686324219547031 0.525 30.3 30 3 abnormal male meiosis 0.0957216102816638 0.259942691676462 0.68578844732256 0.524590163934426 30.3 30 3 abnormal cytotoxic T cell physiology 0.152218588375966 0.357211074136995 0.684767928799759 0.523809523809524 30.3 30 3 hypoalgesia 0.267439808642406 0.497946499998493 0.684767928799759 0.523809523809524 30.3 30 3 increased keratinocyte proliferation 0.267439808642406 0.497946499998493 0.684767928799759 0.523809523809524 30.3 30 3 abnormal gametogenesis 0.148298476583737 0.349636139261802 0.683353119029512 0.522727272727273 30.3 30 3 hyperkeratosis 0.0873238354732696 0.242295639419697 0.682061336195807 0.521739130434783 30.3 30 3 blistering 0.258233571876541 0.48116555059393 0.682061336195807 0.521739130434783 30.3 30 3 abnormal intestinal epithelium morphology 0.140807650871714 0.342140030506066 0.680877201931579 0.520833333333333 30.3 30 3 abnormal osteoclast morphology 0.140807650871714 0.342140030506066 0.680877201931579 0.520833333333333 30.3 30 3 testicular atrophy 0.137229462619775 0.338481198082985 0.679787798408488 0.52 30.3 30 3 abnormal circulating protein level 0.137229462619775 0.338481198082985 0.679787798408488 0.52 30.3 30 3 increased pre-B cell number 0.249566851138942 0.465191114430962 0.679787798408488 0.52 30.3 30 3 focal hair loss 0.233626567211044 0.435641743581313 0.676181497090671 0.517241379310345 30.3 30 3 increased double-positive T cell number 0.233626567211044 0.435641743581313 0.676181497090671 0.517241379310345 30.3 30 3 abnormal immune system physiology 0.0387408666046732 0.14087566235322 0.674727343333487 0.516129032258065 30.3 30 3 autoimmune response 0.22626336718113 0.428438023226534 0.674727343333487 0.516129032258065 30.3 30 3 decreased double-negative T cell number 0.22626336718113 0.428438023226534 0.674727343333487 0.516129032258065 30.3 30 3 abnormal intestine physiology 0.22626336718113 0.428438023226534 0.674727343333487 0.516129032258065 30.3 30 3 absent vibrissae 0.219256390299236 0.428438023226534 0.67344945063778 0.515151515151515 30.3 30 3 increased white adipose tissue amount 0.206195580208805 0.428438023226534 0.671308116931459 0.513513513513513 30.3 30 3 obese 0.119191302534634 0.303312905427009 0.6621309724758 0.506493506493506 30.3 30 3 increased susceptibility to bacterial infection induced morbidity/mortality 0.153330374987362 0.359650455239098 0.653642113854315 0.5 30.3 30 3 impaired fertilization 0.157516820292845 0.369122082410222 0.653642113854315 0.5 30.3 30 3 thin skin 0.269368477885485 0.501162370037504 0.653642113854315 0.5 30.3 30 3 abnormal skin physiology 0.269368477885485 0.501162370037504 0.653642113854315 0.5 30.3 30 3 abnormal crypts of Lieberkuhn morphology 0.278826550111881 0.517019040926801 0.653642113854315 0.5 30.3 30 3 abnormal spleen germinal center morphology 0.299556079922309 0.550939555494819 0.653642113854315 0.5 30.3 30 3 decreased circulating progesterone level 0.299556079922309 0.550939555494819 0.653642113854315 0.5 30.3 30 3 abnormal mouth morphology 0.38422613097084 0.584974125559652 0.653642113854315 0.5 30.3 30 3 abnormal stomach glandular epithelium morphology 0.366733273290522 0.584974125559652 0.653642113854315 0.5 30.3 30 3 intestinal ulcer 0.336521224940848 0.584974125559652 0.653642113854315 0.5 30.3 30 3 abnormal kidney blood vessel morphology 0.403851349322212 0.584974125559652 0.653642113854315 0.5 30.3 30 3 abnormal retinal rod cell morphology 0.366733273290522 0.584974125559652 0.653642113854315 0.5 30.3 30 3 irregularly shaped pupil 0.403851349322212 0.584974125559652 0.653642113854315 0.5 30.3 30 3 increased activated T cell number 0.336521224940848 0.584974125559652 0.653642113854315 0.5 30.3 30 3 abnormal antigen presentation 0.403851349322212 0.584974125559652 0.653642113854315 0.5 30.3 30 3 intestinal inflammation 0.336521224940848 0.584974125559652 0.653642113854315 0.5 30.3 30 3 testis hypoplasia 0.336521224940848 0.584974125559652 0.653642113854315 0.5 30.3 30 3 acidosis 0.366733273290522 0.584974125559652 0.653642113854315 0.5 30.3 30 3 increased circulating glycerol level 0.366733273290522 0.584974125559652 0.653642113854315 0.5 30.3 30 3 abnormal uterus development 0.403851349322212 0.584974125559652 0.653642113854315 0.5 30.3 30 3 abnormal female reproductive system physiology 0.336521224940848 0.584974125559652 0.653642113854315 0.5 30.3 30 3 abnormal imprinting 0.403851349322212 0.584974125559652 0.653642113854315 0.5 30.3 30 3 abnormal decidualization 0.403851349322212 0.584974125559652 0.653642113854315 0.5 30.3 30 3 small epididymis 0.38422613097084 0.584974125559652 0.653642113854315 0.5 30.3 30 3 abnormal iris pigmentation 0.403851349322212 0.584974125559652 0.653642113854315 0.5 30.3 30 3 decreased circulating growth hormone level 0.38422613097084 0.584974125559652 0.653642113854315 0.5 30.3 30 3 increased circulating growth hormone level 0.403851349322212 0.584974125559652 0.653642113854315 0.5 30.3 30 3 abnormal pancreatic alpha cell morphology 0.38422613097084 0.584974125559652 0.653642113854315 0.5 30.3 30 3 abnormal temporal bone morphology 0.336521224940848 0.584974125559652 0.653642113854315 0.5 30.3 30 3 jerky movement 0.366733273290522 0.584974125559652 0.653642113854315 0.5 30.3 30 3 decreased susceptibility to viral infection induced morbidity/mortality 0.336521224940848 0.584974125559652 0.653642113854315 0.5 30.3 30 3 abnormal urinary bladder physiology 0.38422613097084 0.584974125559652 0.653642113854315 0.5 30.3 30 3 increased percent body fat/body weight 0.202909976152203 0.427382358745643 0.653642113854315 0.5 30.3 30 3 kidney inflammation 0.209012471721079 0.428438023226534 0.653642113854315 0.5 30.3 30 3 abnormal hair shaft morphology 0.215379890325029 0.428438023226534 0.653642113854315 0.5 30.3 30 3 salivary gland inflammation 0.288865235164542 0.533644465259412 0.653642113854315 0.5 30.3 30 3 abnormal pain threshold 0.288865235164542 0.533644465259412 0.653642113854315 0.5 30.3 30 3 decreased Peyer's patch number 0.31098609373444 0.56941376938213 0.653642113854315 0.5 30.3 30 3 amyloidosis 0.426255128106812 0.584974125559652 0.653642113854315 0.5 30.3 30 3 impaired embryo implantation 0.426255128106812 0.584974125559652 0.653642113854315 0.5 30.3 30 3 brain inflammation 0.350935155712203 0.584974125559652 0.653642113854315 0.5 30.3 30 3 increased litter size 0.426255128106812 0.584974125559652 0.653642113854315 0.5 30.3 30 3 abnormal tracheal ciliated epithelium morphology 0.426255128106812 0.584974125559652 0.653642113854315 0.5 30.3 30 3 decreased skin tensile strength 0.350935155712203 0.584974125559652 0.653642113854315 0.5 30.3 30 3 decreased circulating ketone body level 0.426255128106812 0.584974125559652 0.653642113854315 0.5 30.3 30 3 abnormal male reproductive system physiology 0.350935155712203 0.584974125559652 0.653642113854315 0.5 30.3 30 3 small parietal bone 0.426255128106812 0.584974125559652 0.653642113854315 0.5 30.3 30 3 decreased keratinocyte proliferation 0.426255128106812 0.584974125559652 0.653642113854315 0.5 30.3 30 3 abnormal cellular extravasation 0.323262751381763 0.584974125559652 0.653642113854315 0.5 30.3 30 3 nuclear cataracts 0.350935155712203 0.584974125559652 0.653642113854315 0.5 30.3 30 3 increased skeletal muscle glycogen level 0.426255128106812 0.584974125559652 0.653642113854315 0.5 30.3 30 3 abnormal auchene hair morphology 0.45245126432511 0.607214739686383 0.653642113854315 0.5 30.3 30 3 abnormal epidermis suprabasal layer morphology 0.45245126432511 0.607214739686383 0.653642113854315 0.5 30.3 30 3 abnormal grooming behavior 0.45245126432511 0.607214739686383 0.653642113854315 0.5 30.3 30 3 absent trophoblast giant cells 0.45245126432511 0.607214739686383 0.653642113854315 0.5 30.3 30 3 decreased incidence of induced tumors 0.45245126432511 0.607214739686383 0.653642113854315 0.5 30.3 30 3 abnormal primordial germ cell migration 0.45245126432511 0.607214739686383 0.653642113854315 0.5 30.3 30 3 intestinal hypoperistalsis 0.45245126432511 0.607214739686383 0.653642113854315 0.5 30.3 30 3 bifid ureter 0.45245126432511 0.607214739686383 0.653642113854315 0.5 30.3 30 3 cochlear ganglion hypoplasia 0.45245126432511 0.607214739686383 0.653642113854315 0.5 30.3 30 3 abnormal gas homeostasis 0.45245126432511 0.607214739686383 0.653642113854315 0.5 30.3 30 3 abnormal deltoid tuberosity morphology 0.45245126432511 0.607214739686383 0.653642113854315 0.5 30.3 30 3 decreased prolactin level 0.45245126432511 0.607214739686383 0.653642113854315 0.5 30.3 30 3 absent axillary lymph nodes 0.45245126432511 0.607214739686383 0.653642113854315 0.5 30.3 30 3 ventricular premature beat 0.45245126432511 0.607214739686383 0.653642113854315 0.5 30.3 30 3 abnormal sperm principal piece morphology 0.45245126432511 0.607214739686383 0.653642113854315 0.5 30.3 30 3 common ventricle 0.45245126432511 0.607214739686383 0.653642113854315 0.5 30.3 30 3 sinus bradycardia 0.45245126432511 0.607214739686383 0.653642113854315 0.5 30.3 30 3 decreased trabecular bone connectivity density 0.45245126432511 0.607214739686383 0.653642113854315 0.5 30.3 30 3 decreased macrophage cytokine production 0.45245126432511 0.607214739686383 0.653642113854315 0.5 30.3 30 3 increased susceptibility to parasitic infection 0.169192214297425 0.395922514642376 0.639116733546442 0.488888888888889 30.3 30 3 abnormal intestinal mucosa morphology 0.28174786705255 0.522046792769622 0.638441134462355 0.488372093023256 30.3 30 3 abnormal leukocyte adhesion 0.301243152636473 0.553837651281024 0.636882059652923 0.487179487179487 30.3 30 3 decreased susceptibility to injury 0.228491325235542 0.428438023226534 0.634417345799777 0.485294117647059 30.3 30 3 abnormal circulating glucose level 0.361090291786155 0.584974125559652 0.63110273061796 0.482758620689655 30.3 30 3 decreased retinal photoreceptor cell number 0.361090291786155 0.584974125559652 0.63110273061796 0.482758620689655 30.3 30 3 stomach inflammation 0.361090291786155 0.584974125559652 0.63110273061796 0.482758620689655 30.3 30 3 polyphagia 0.28112449567918 0.521085829360627 0.629433146674526 0.481481481481481 30.3 30 3 decreased acute inflammation 0.39128973622129 0.584974125559652 0.627496429300143 0.48 30.3 30 3 impaired conditioned place preference behavior 0.39128973622129 0.584974125559652 0.627496429300143 0.48 30.3 30 3 pancreas inflammation 0.408284906916463 0.584974125559652 0.625222891512824 0.478260869565217 30.3 30 3 abnormal crista ampullaris morphology 0.408284906916463 0.584974125559652 0.625222891512824 0.478260869565217 30.3 30 3 abnormal bile salt homeostasis 0.426840016684744 0.584974125559652 0.622516298908872 0.476190476190476 30.3 30 3 impaired ovarian folliculogenesis 0.353101234472682 0.584974125559652 0.6209600081616 0.475 30.3 30 3 decreased regulatory T cell number 0.393136231757823 0.584974125559652 0.615192577745238 0.470588235294118 30.3 30 3 increased aggression towards mice 0.469957189056631 0.63002883739066 0.615192577745238 0.470588235294118 30.3 30 3 abnormal melanosome morphology 0.469957189056631 0.63002883739066 0.615192577745238 0.470588235294118 30.3 30 3 increased systemic arterial blood pressure 0.367651079799474 0.584974125559652 0.611920276799785 0.468085106382979 30.3 30 3 abnormal estrous cycle 0.424287216330066 0.584974125559652 0.610065972930694 0.466666666666667 30.3 30 3 abnormal pup retrieval 0.495492455388016 0.657002922589387 0.610065972930694 0.466666666666667 30.3 30 3 abnormal apical ectodermal ridge morphology 0.495492455388016 0.657002922589387 0.610065972930694 0.466666666666667 30.3 30 3 abnormal neurotransmitter secretion 0.495492455388016 0.657002922589387 0.610065972930694 0.466666666666667 30.3 30 3 abnormal energy homeostasis 0.495492455388016 0.657002922589387 0.610065972930694 0.466666666666667 30.3 30 3 increased circulating luteinizing hormone level 0.441541351898955 0.595625874646774 0.60695339143615 0.464285714285714 30.3 30 3 abnormal ovulation 0.441541351898955 0.595625874646774 0.60695339143615 0.464285714285714 30.3 30 3 increased susceptibility to injury 0.391662476057034 0.584974125559652 0.603361951250137 0.461538461538462 30.3 30 3 decreased body temperature 0.391662476057034 0.584974125559652 0.603361951250137 0.461538461538462 30.3 30 3 abnormal leukocyte cell number 0.460121429781446 0.617175549518117 0.603361951250137 0.461538461538462 30.3 30 3 abnormal tectorial membrane morphology 0.460121429781446 0.617175549518117 0.603361951250137 0.461538461538462 30.3 30 3 abnormal renal/urinary system morphology 0.524674837369002 0.686400456647679 0.603361951250137 0.461538461538462 30.3 30 3 pup cannibalization 0.524674837369002 0.686400456647679 0.603361951250137 0.461538461538462 30.3 30 3 abnormal intercostal muscle morphology 0.524674837369002 0.686400456647679 0.603361951250137 0.461538461538462 30.3 30 3 abnormal dopaminergic neuron morphology 0.524674837369002 0.686400456647679 0.603361951250137 0.461538461538462 30.3 30 3 decreased alcohol consumption 0.524674837369002 0.686400456647679 0.603361951250137 0.461538461538462 30.3 30 3 vestibular hair cell degeneration 0.524674837369002 0.686400456647679 0.603361951250137 0.461538461538462 30.3 30 3 impaired natural killer cell mediated cytotoxicity 0.413625599289739 0.584974125559652 0.596305086323235 0.456140350877193 30.3 30 3 abnormal large intestine morphology 0.558717959010651 0.727840232018327 0.594220103503923 0.454545454545455 30.3 30 3 patent ductus arteriosus 0.558717959010651 0.727840232018327 0.594220103503923 0.454545454545455 30.3 30 3 abnormal hair medulla 0.558717959010651 0.727840232018327 0.594220103503923 0.454545454545455 30.3 30 3 increased circulating triiodothyronine level 0.558717959010651 0.727840232018327 0.594220103503923 0.454545454545455 30.3 30 3 shortened PR interval 0.558717959010651 0.727840232018327 0.594220103503923 0.454545454545455 30.3 30 3 increased subcutaneous adipose tissue amount 0.558717959010651 0.727840232018327 0.594220103503923 0.454545454545455 30.3 30 3 abnormal response/metabolism to endogenous compounds 0.413405487248298 0.584974125559652 0.589872151527065 0.451219512195122 30.3 30 3 increased urine calcium level 0.526073198887176 0.688016341867429 0.588277902468884 0.45 30.3 30 3 wrinkled skin 0.527722878821623 0.689992463111058 0.581015212314947 0.444444444444444 30.3 30 3 abnormal systemic arterial blood pressure 0.510752708466316 0.67705694767384 0.581015212314947 0.444444444444444 30.3 30 3 thick dermal layer 0.552536321669519 0.72092006302278 0.581015212314947 0.444444444444444 30.3 30 3 increased susceptibility to autoimmune disorder 0.552536321669519 0.72092006302278 0.581015212314947 0.444444444444444 30.3 30 3 abnormal sperm axoneme morphology 0.552536321669519 0.72092006302278 0.581015212314947 0.444444444444444 30.3 30 3 impaired leukocyte tethering or rolling 0.552536321669519 0.72092006302278 0.581015212314947 0.444444444444444 30.3 30 3 increased susceptibility to weight gain 0.529399973164226 0.691821609270298 0.576743041636161 0.441176470588235 30.3 30 3 increased susceptibility to viral infection induced morbidity/mortality 0.529399973164226 0.691821609270298 0.576743041636161 0.441176470588235 30.3 30 3 abnormal feces composition 0.550105798023343 0.718502584711507 0.575205060191798 0.44 30.3 30 3 abnormal energy expenditure 0.550105798023343 0.718502584711507 0.575205060191798 0.44 30.3 30 3 abnormal pituitary gland morphology 0.582032929934709 0.736984939278488 0.571936849622526 0.4375 30.3 30 3 reduced male mating frequency 0.582032929934709 0.736984939278488 0.571936849622526 0.4375 30.3 30 3 abnormal intestinal absorption 0.582032929934709 0.736984939278488 0.571936849622526 0.4375 30.3 30 3 large intestinal inflammation 0.582032929934709 0.736984939278488 0.571936849622526 0.4375 30.3 30 3 abnormal molar crown morphology 0.582032929934709 0.736984939278488 0.571936849622526 0.4375 30.3 30 3 decreased circulating prolactin level 0.582032929934709 0.736984939278488 0.571936849622526 0.4375 30.3 30 3 abnormal Langerhans cell physiology 0.582032929934709 0.736984939278488 0.571936849622526 0.4375 30.3 30 3 abnormal fertilization 0.582032929934709 0.736984939278488 0.571936849622526 0.4375 30.3 30 3 decreased creatinine clearance 0.582032929934709 0.736984939278488 0.571936849622526 0.4375 30.3 30 3 abnormal retinal cone cell morphology 0.574275499205834 0.736984939278488 0.56838444682984 0.434782608695652 30.3 30 3 increased susceptibility to fungal infection 0.574275499205834 0.736984939278488 0.56838444682984 0.434782608695652 30.3 30 3 decreased coping response 0.615292453404094 0.775153192120883 0.560264669017985 0.428571428571429 30.3 30 3 abnormal prepulse inhibition 0.615292453404094 0.775153192120883 0.560264669017985 0.428571428571429 30.3 30 3 abnormal hair cuticle 0.615292453404094 0.775153192120883 0.560264669017985 0.428571428571429 30.3 30 3 abnormal squamosal bone morphology 0.615292453404094 0.775153192120883 0.560264669017985 0.428571428571429 30.3 30 3 abnormal renal reabsorbtion 0.615292453404094 0.775153192120883 0.560264669017985 0.428571428571429 30.3 30 3 decreased compact bone area 0.615292453404094 0.775153192120883 0.560264669017985 0.428571428571429 30.3 30 3 increased acute inflammation 0.600498085539 0.75766623777746 0.560264669017985 0.428571428571429 30.3 30 3 decreased susceptibility to bacterial infection induced morbidity/mortality 0.629750685380216 0.79316700247255 0.548215966458458 0.419354838709677 30.3 30 3 abnormal esophagus morphology 0.653334266799108 0.797060013973457 0.544701761545263 0.416666666666667 30.3 30 3 abnormal rectum morphology 0.653334266799108 0.797060013973457 0.544701761545263 0.416666666666667 30.3 30 3 decreased digestive secretion 0.653334266799108 0.797060013973457 0.544701761545263 0.416666666666667 30.3 30 3 small lymph nodes 0.641453190902544 0.797060013973457 0.544701761545263 0.416666666666667 30.3 30 3 increased fear-related response 0.653334266799108 0.797060013973457 0.544701761545263 0.416666666666667 30.3 30 3 absent cochlear hair cells 0.653334266799108 0.797060013973457 0.544701761545263 0.416666666666667 30.3 30 3 abnormal palatine bone morphology 0.653334266799108 0.797060013973457 0.544701761545263 0.416666666666667 30.3 30 3 abnormal behavioral response to addictive substance 0.653334266799108 0.797060013973457 0.544701761545263 0.416666666666667 30.3 30 3 decreased compensatory feeding amount 0.653334266799108 0.797060013973457 0.544701761545263 0.416666666666667 30.3 30 3 increased susceptibility to induced arthritis 0.652677508088694 0.797060013973457 0.540945197672537 0.413793103448276 30.3 30 3 enlarged epididymis 0.652677508088694 0.797060013973457 0.540945197672537 0.413793103448276 30.3 30 3 hydroureter 0.660485948549364 0.797060013973457 0.538293505527083 0.411764705882353 30.3 30 3 abnormal heart rate 0.660485948549364 0.797060013973457 0.538293505527083 0.411764705882353 30.3 30 3 abnormal circulating chemokine level 0.660485948549364 0.797060013973457 0.538293505527083 0.411764705882353 30.3 30 3 abnormal epidermis stratum spinosum morphology 0.695159118748145 0.815087583259963 0.522913691083452 0.4 30.3 30 3 abnormal respiratory system morphology 0.695159118748145 0.815087583259963 0.522913691083452 0.4 30.3 30 3 joint inflammation 0.695159118748145 0.815087583259963 0.522913691083452 0.4 30.3 30 3 greasy coat 0.695159118748145 0.815087583259963 0.522913691083452 0.4 30.3 30 3 lactation failure 0.695159118748145 0.815087583259963 0.522913691083452 0.4 30.3 30 3 decreased epididymis weight 0.729263312341139 0.84511646375429 0.511546002146856 0.391304347826087 30.3 30 3 abnormal body temperature homeostasis 0.756991467074845 0.872170576354181 0.506045507500115 0.387096774193548 30.3 30 3 abnormal GABAergic neuron morphology 0.733746410192924 0.849717968042317 0.502801626041781 0.384615384615385 30.3 30 3 increased renin activity 0.733746410192924 0.849717968042317 0.502801626041781 0.384615384615385 30.3 30 3 total cataracts 0.733746410192924 0.849717968042317 0.502801626041781 0.384615384615385 30.3 30 3 increased vasoconstriction 0.757653479061614 0.872731201280743 0.498013039127097 0.380952380952381 30.3 30 3 altered susceptibility to infection 0.787561767344416 0.905923651453981 0.481631031261074 0.368421052631579 30.3 30 3 abnormal olfactory system physiology 0.799554163964496 0.913616776080941 0.466887224181654 0.357142857142857 30.3 30 3 abnormal kidney medulla morphology 0.799554163964496 0.913616776080941 0.466887224181654 0.357142857142857 30.3 30 3 decreased vascular permeability 0.799554163964496 0.913616776080941 0.466887224181654 0.357142857142857 30.3 30 3 abnormal respiratory motile cilium physiology 0.799554163964496 0.913616776080941 0.466887224181654 0.357142857142857 30.3 30 3 decreased susceptibility to parasitic infection 0.886380831633303 0.984977582616861 0.449378953274842 0.34375 30.3 30 3 abnormal stomach mucosa morphology 0.912775054416543 1 0.418330952866762 0.32 30.3 30 3 abnormal epididymis epithelium morphology 0.892077529543791 0.985286579030114 0.408526321158947 0.3125 30.3 30 3 abnormal regulatory T cell physiology 0.930231818600129 1 0.397869112780888 0.304347826086957 30.3 30 3 abnormal circulating cytokine level 0.926159058167276 1 0.392185268312589 0.3 30.3 30 3 decreased airway responsiveness 0.961818380269747 1 0.356532062102354 0.272727272727273 30.3 30 3 delayed brain development 0.00262584782640857 0.0171889380741877 1.6919536581495 1 30.1 30 1 decreased liver function 0.00262584782640857 0.0171889380741877 1.6919536581495 1 30.1 30 1 absent parietal bone 0.00262584782640857 0.0171889380741877 1.6919536581495 1 30.1 30 1 decreased platelet ADP level 0.00262584782640857 0.0171889380741877 1.6919536581495 1 30.1 30 1 abnormal aorta tunica adventitia morphology 0.00262584782640857 0.0171889380741877 1.6919536581495 1 30.1 30 1 thymus cortex atrophy 0.00262584782640857 0.0171889380741877 1.6919536581495 1 30.1 30 1 abnormal vertebral artery origin 0.00262584782640857 0.0171889380741877 1.6919536581495 1 30.1 30 1 additional anastomosis between intracranial vertebral arteries 0.00262584782640857 0.0171889380741877 1.6919536581495 1 30.1 30 1 abnormal respiratory conducting tube morphology 4.99285731513735e-05 0.000592827330377287 1.6919536581495 1 30.1 30 1 abnormal vibrissa follicle morphology 4.99285731513735e-05 0.000592827330377287 1.6919536581495 1 30.1 30 1 liver hyperplasia 0.000134465779276489 0.00140271866203164 1.6919536581495 1 30.1 30 1 abnormal pulmonary alveolar system morphology 0.000134465779276489 0.00140271866203164 1.6919536581495 1 30.1 30 1 abnormal extraembryonic tissue physiology 0.000362120165947389 0.00327911497934395 1.6919536581495 1 30.1 30 1 long femur 0.000362120165947389 0.00327911497934395 1.6919536581495 1 30.1 30 1 decreased alveolar lamellar body number 0.000362120165947389 0.00327911497934395 1.6919536581495 1 30.1 30 1 increased mammary gland apoptosis 0.000362120165947389 0.00327911497934395 1.6919536581495 1 30.1 30 1 mammary gland hyperplasia 0.000975151224171305 0.00741800816552331 1.6919536581495 1 30.1 30 1 abnormal tumor incidence 0.000975151224171305 0.00741800816552331 1.6919536581495 1 30.1 30 1 abnormal gastrulation movements 0.000975151224171305 0.00741800816552331 1.6919536581495 1 30.1 30 1 small lung lobe 0.000975151224171305 0.00741800816552331 1.6919536581495 1 30.1 30 1 impaired branching involved in bronchus morphogenesis 0.000975151224171305 0.00741800816552331 1.6919536581495 1 30.1 30 1 absent heart tube 0.000975151224171305 0.00741800816552331 1.6919536581495 1 30.1 30 1 abnormal pineal gland morphology 0.00707042410287785 0.0371439914591524 1.6919536581495 1 30.1 30 1 absent lungs 0.00707042410287785 0.0371439914591524 1.6919536581495 1 30.1 30 1 decreased sensitivity to skin irradiation 0.00707042410287785 0.0371439914591524 1.6919536581495 1 30.1 30 1 abnormal penile erection 0.00707042410287785 0.0371439914591524 1.6919536581495 1 30.1 30 1 abnormal type I pneumocyte morphology 0.00707042410287785 0.0371439914591524 1.6919536581495 1 30.1 30 1 decreased lysosomal enzyme secretion 0.00707042410287785 0.0371439914591524 1.6919536581495 1 30.1 30 1 increased lysosomal enzyme secretion 0.00707042410287785 0.0371439914591524 1.6919536581495 1 30.1 30 1 gastric polyps 0.00707042410287785 0.0371439914591524 1.6919536581495 1 30.1 30 1 epidermal cyst 0.00707042410287785 0.0371439914591524 1.6919536581495 1 30.1 30 1 abnormal hypodermis morphology 0.00707042410287785 0.0371439914591524 1.6919536581495 1 30.1 30 1 increased heart right ventricle weight 0.00707042410287785 0.0371439914591524 1.6919536581495 1 30.1 30 1 abnormal Reichert's membrane morphology 0.00707042410287785 0.0371439914591524 1.6919536581495 1 30.1 30 1 decreased unsaturated fatty acid level 0.00707042410287785 0.0371439914591524 1.6919536581495 1 30.1 30 1 increased placenta apoptosis 0.00707042410287785 0.0371439914591524 1.6919536581495 1 30.1 30 1 palatal shelf fusion with tongue or mandible 0.00707042410287785 0.0371439914591524 1.6919536581495 1 30.1 30 1 abnormal olfactory bulb granule cell layer morphology 0.00707042410287785 0.0371439914591524 1.6919536581495 1 30.1 30 1 increased mammary gland epithelial cell proliferation 0.00707042410287785 0.0371439914591524 1.6919536581495 1 30.1 30 1 aorta hypoplasia 0.00707042410287785 0.0371439914591524 1.6919536581495 1 30.1 30 1 enlarged aortic valve 0.00707042410287785 0.0371439914591524 1.6919536581495 1 30.1 30 1 increased Schwann cell number 0.00707042410287785 0.0371439914591524 1.6919536581495 1 30.1 30 1 enlarged alveolar lamellar bodies 0.00707042410287785 0.0371439914591524 1.6919536581495 1 30.1 30 1 trachea stenosis 0.00707042410287785 0.0371439914591524 1.6919536581495 1 30.1 30 1 pale lung 0.00707042410287785 0.0371439914591524 1.6919536581495 1 30.1 30 1 pulmonary alveolar edema 0.00707042410287785 0.0371439914591524 1.6919536581495 1 30.1 30 1 abnormal pulmonary alveolus epithelium morphology 0.00707042410287785 0.0371439914591524 1.6919536581495 1 30.1 30 1 alveolitis 0.00707042410287785 0.0371439914591524 1.6919536581495 1 30.1 30 1 abnormal lung alveolus development 0.00707042410287785 0.0371439914591524 1.6919536581495 1 30.1 30 1 blind ureter 0.00707042410287785 0.0371439914591524 1.6919536581495 1 30.1 30 1 podocyte microvillus transformation 0.00707042410287785 0.0371439914591524 1.6919536581495 1 30.1 30 1 absent foregut 0.00707042410287785 0.0371439914591524 1.6919536581495 1 30.1 30 1 abnormal mitophagy 0.00707042410287785 0.0371439914591524 1.6919536581495 1 30.1 30 1 decreased small intestinal villus height 0.00707042410287785 0.0371439914591524 1.6919536581495 1 30.1 30 1 immune system phenotype 9.29904980928367e-06 0.000135677649248344 1.5791567476062 0.933333333333333 30.1 30 1 heterochrony 9.29904980928367e-06 0.000135677649248344 1.5791567476062 0.933333333333333 30.1 30 1 increased osteosarcoma incidence 0.000146747307461702 0.00150840465830985 1.55095751997038 0.916666666666667 30.1 30 1 decreased prostaglandin level 0.000146747307461702 0.00150840465830985 1.55095751997038 0.916666666666667 30.1 30 1 increased type II pneumocyte number 0.000146747307461702 0.00150840465830985 1.55095751997038 0.916666666666667 30.1 30 1 prenatal growth retardation 0.000146747307461702 0.00150840465830985 1.55095751997038 0.916666666666667 30.1 30 1 delayed hepatic development 0.000363833461024695 0.00327911497934395 1.53813968922682 0.909090909090909 30.1 30 1 abnormal dorsal-ventral polarity of the somites 0.000363833461024695 0.00327911497934395 1.53813968922682 0.909090909090909 30.1 30 1 abnormal pulmonary alveolar sac morphology 0.000363833461024695 0.00327911497934395 1.53813968922682 0.909090909090909 30.1 30 1 abnormal auchene hair morphology 0.000895300634402533 0.00699234011954882 1.52275829233455 0.9 30.1 30 1 abnormal embryonic erythrocyte morphology 0.000895300634402533 0.00699234011954882 1.52275829233455 0.9 30.1 30 1 osteosclerosis 0.000895300634402533 0.00699234011954882 1.52275829233455 0.9 30.1 30 1 vascular smooth muscle hyperplasia 0.000895300634402533 0.00699234011954882 1.52275829233455 0.9 30.1 30 1 decreased transitional stage T2 B cell number 0.000895300634402533 0.00699234011954882 1.52275829233455 0.9 30.1 30 1 abnormal heart and great artery attachment 0.000895300634402533 0.00699234011954882 1.52275829233455 0.9 30.1 30 1 thin ventricle myocardium compact layer 0.000895300634402533 0.00699234011954882 1.52275829233455 0.9 30.1 30 1 thick aortic valve 0.000895300634402533 0.00699234011954882 1.52275829233455 0.9 30.1 30 1 heart hyperplasia 0.00218335525931459 0.0147986272685151 1.503958807244 0.888888888888889 30.1 30 1 distorted hair follicle pattern 0.00218335525931459 0.0147986272685151 1.503958807244 0.888888888888889 30.1 30 1 dilated uterus 0.00218335525931459 0.0147986272685151 1.503958807244 0.888888888888889 30.1 30 1 decreased level of surface class I molecules 0.00218335525931459 0.0147986272685151 1.503958807244 0.888888888888889 30.1 30 1 abnormal artery development 0.00218335525931459 0.0147986272685151 1.503958807244 0.888888888888889 30.1 30 1 abnormal intervertebral disk development 0.00218335525931459 0.0147986272685151 1.503958807244 0.888888888888889 30.1 30 1 decreased transitional stage T1 B cell number 0.00218335525931459 0.0147986272685151 1.503958807244 0.888888888888889 30.1 30 1 abnormal lung lobe morphology 0.00218335525931459 0.0147986272685151 1.503958807244 0.888888888888889 30.1 30 1 symmetric azygos veins 0.00218335525931459 0.0147986272685151 1.503958807244 0.888888888888889 30.1 30 1 abnormal dorsal-ventral axis patterning 2.03809468063453e-05 0.000268952812630153 1.4929002866025 0.882352941176471 30.1 30 1 abnormal primitive streak morphology 2.11241413306972e-07 4.77693650546447e-06 1.48891921917156 0.88 30.1 30 1 abnormal foregut morphology 5.02684101815791e-07 9.96355938857993e-06 1.48045945088081 0.875 30.1 30 1 abnormal lung saccule morphology 5.02684101815791e-07 9.96355938857993e-06 1.48045945088081 0.875 30.1 30 1 kidney degeneration 4.86779758472884e-05 0.000580750431271606 1.48045945088081 0.875 30.1 30 1 abnormal bone marrow development 0.00526636863173872 0.0299813323747206 1.48045945088081 0.875 30.1 30 1 abnormal pulmonary circulation 0.00526636863173872 0.0299813323747206 1.48045945088081 0.875 30.1 30 1 early eyelid opening 0.00526636863173872 0.0299813323747206 1.48045945088081 0.875 30.1 30 1 abnormal eyelid aperture 0.00526636863173872 0.0299813323747206 1.48045945088081 0.875 30.1 30 1 increased left ventricle systolic pressure 0.00526636863173872 0.0299813323747206 1.48045945088081 0.875 30.1 30 1 abnormal kidney epithelium morphology 0.00526636863173872 0.0299813323747206 1.48045945088081 0.875 30.1 30 1 craniofacial phenotype 0.00526636863173872 0.0299813323747206 1.48045945088081 0.875 30.1 30 1 stomach epithelial hyperplasia 0.00526636863173872 0.0299813323747206 1.48045945088081 0.875 30.1 30 1 abnormal cerebellum deep nucleus morphology 0.00526636863173872 0.0299813323747206 1.48045945088081 0.875 30.1 30 1 abnormal lateral plate mesoderm morphology 0.00526636863173872 0.0299813323747206 1.48045945088081 0.875 30.1 30 1 abnormal kidney mesenchyme morphology 0.00526636863173872 0.0299813323747206 1.48045945088081 0.875 30.1 30 1 decreased surfactant secretion 0.00526636863173872 0.0299813323747206 1.48045945088081 0.875 30.1 30 1 increased circulating ferritin level 0.00526636863173872 0.0299813323747206 1.48045945088081 0.875 30.1 30 1 abnormal umbilical vein topology 0.00526636863173872 0.0299813323747206 1.48045945088081 0.875 30.1 30 1 embryo cyst 0.00526636863173872 0.0299813323747206 1.48045945088081 0.875 30.1 30 1 pale kidney 1.2890979560079e-08 3.86341104285501e-07 1.47363705709795 0.870967741935484 30.1 30 1 abnormal Wolffian duct morphology 1.18977031608164e-06 2.20862213526348e-05 1.47126405056478 0.869565217391304 30.1 30 1 delayed intramembranous bone ossification 0.000115367840263069 0.00121600636717959 1.4663598370629 0.866666666666667 30.1 30 1 abnormal branching involved in lung morphogenesis 0.000115367840263069 0.00121600636717959 1.4663598370629 0.866666666666667 30.1 30 1 abnormal lysosome physiology 2.79945831817047e-06 4.80251901134417e-05 1.46123270476548 0.863636363636364 30.1 30 1 abnormal occipital bone morphology 2.79945831817047e-06 4.80251901134417e-05 1.46123270476548 0.863636363636364 30.1 30 1 abnormal tumor vascularization 6.54469473053211e-06 0.000100493383593819 1.45024599269957 0.857142857142857 30.1 30 1 vascular smooth muscle hypoplasia 0.00027103649772757 0.00256839347846602 1.45024599269957 0.857142857142857 30.1 30 1 abnormal maternal decidual layer morphology 0.00027103649772757 0.00256839347846602 1.45024599269957 0.857142857142857 30.1 30 1 lysosomal protein accumulation 0.00027103649772757 0.00256839347846602 1.45024599269957 0.857142857142857 30.1 30 1 cellular necrosis 0.0125300274398321 0.0576126492727956 1.45024599269957 0.857142857142857 30.1 30 1 broad head 0.0125300274398321 0.0576126492727956 1.45024599269957 0.857142857142857 30.1 30 1 decreased Schwann cell number 0.0125300274398321 0.0576126492727956 1.45024599269957 0.857142857142857 30.1 30 1 skin photosensitivity 0.0125300274398321 0.0576126492727956 1.45024599269957 0.857142857142857 30.1 30 1 retina hyperplasia 0.0125300274398321 0.0576126492727956 1.45024599269957 0.857142857142857 30.1 30 1 decreased activated T cell number 0.0125300274398321 0.0576126492727956 1.45024599269957 0.857142857142857 30.1 30 1 abnormal brain ventricular system morphology 0.0125300274398321 0.0576126492727956 1.45024599269957 0.857142857142857 30.1 30 1 aorta coarctation 0.0125300274398321 0.0576126492727956 1.45024599269957 0.857142857142857 30.1 30 1 anuria 0.0125300274398321 0.0576126492727956 1.45024599269957 0.857142857142857 30.1 30 1 abnormal MHC II cell surface expression on macrophages 0.0125300274398321 0.0576126492727956 1.45024599269957 0.857142857142857 30.1 30 1 absent popliteal lymph nodes 0.0125300274398321 0.0576126492727956 1.45024599269957 0.857142857142857 30.1 30 1 abnormal uterus physiology 0.0125300274398321 0.0576126492727956 1.45024599269957 0.857142857142857 30.1 30 1 heart hemorrhage 0.0125300274398321 0.0576126492727956 1.45024599269957 0.857142857142857 30.1 30 1 postaxial polydactyly 0.0125300274398321 0.0576126492727956 1.45024599269957 0.857142857142857 30.1 30 1 decreased DN2 thymocyte number 0.0125300274398321 0.0576126492727956 1.45024599269957 0.857142857142857 30.1 30 1 arteritis 0.0125300274398321 0.0576126492727956 1.45024599269957 0.857142857142857 30.1 30 1 abnormal conotruncal ridge morphology 0.0125300274398321 0.0576126492727956 1.45024599269957 0.857142857142857 30.1 30 1 abnormal aortic valve cusp morphology 0.0125300274398321 0.0576126492727956 1.45024599269957 0.857142857142857 30.1 30 1 altered tumor pathology 0.0125300274398321 0.0576126492727956 1.45024599269957 0.857142857142857 30.1 30 1 increased compact bone volume 0.0125300274398321 0.0576126492727956 1.45024599269957 0.857142857142857 30.1 30 1 small tail bud 0.0125300274398321 0.0576126492727956 1.45024599269957 0.857142857142857 30.1 30 1 impaired mammary gland growth during pregnancy 0.0125300274398321 0.0576126492727956 1.45024599269957 0.857142857142857 30.1 30 1 decreased circulating fructosamine level 3.84824043335386e-07 7.84630989997354e-06 1.44129385694217 0.851851851851852 30.1 30 1 dilated vasculature 1.5192728109609e-05 0.000208795089351671 1.43816060942707 0.85 30.1 30 1 abnormal grip strength 0.000630390061471827 0.00521828711451304 1.43165309535727 0.846153846153846 30.1 30 1 abnormal pulmonary alveolus epithelial cell morphology 0.000630390061471827 0.00521828711451304 1.43165309535727 0.846153846153846 30.1 30 1 abnormal tail bud morphology 0.000630390061471827 0.00521828711451304 1.43165309535727 0.846153846153846 30.1 30 1 axonal dystrophy 0.000630390061471827 0.00521828711451304 1.43165309535727 0.846153846153846 30.1 30 1 abnormal aorta tunica media morphology 0.000630390061471827 0.00521828711451304 1.43165309535727 0.846153846153846 30.1 30 1 kidney cortex cysts 5.30741832738288e-08 1.37522948847551e-06 1.42758589906364 0.84375 30.1 30 1 abnormal digestive system development 3.49942921594732e-05 0.000434156118437354 1.42480308054695 0.842105263157895 30.1 30 1 embryonic lethality between implantation and somite formation, incomplete penetrance 3.49942921594732e-05 0.000434156118437354 1.42480308054695 0.842105263157895 30.1 30 1 abnormal interventricular septum morphology 1.22612573857218e-11 5.98036818568295e-10 1.42124107284558 0.84 30.1 30 1 abnormal mitral valve morphology 7.99109457902883e-05 0.000893386416419515 1.40996138179125 0.833333333333333 30.1 30 1 abnormal stomach glandular epithelium morphology 7.99109457902883e-05 0.000893386416419515 1.40996138179125 0.833333333333333 30.1 30 1 long tibia 7.99109457902883e-05 0.000893386416419515 1.40996138179125 0.833333333333333 30.1 30 1 abnormal aerobic respiration 7.99109457902883e-05 0.000893386416419515 1.40996138179125 0.833333333333333 30.1 30 1 interstitial pneumonia 0.00144926422883967 0.0105565000563358 1.40996138179125 0.833333333333333 30.1 30 1 loss of dopaminergic neurons 0.00144926422883967 0.0105565000563358 1.40996138179125 0.833333333333333 30.1 30 1 small intestinal inflammation 0.00144926422883967 0.0105565000563358 1.40996138179125 0.833333333333333 30.1 30 1 absent ovary 0.00144926422883967 0.0105565000563358 1.40996138179125 0.833333333333333 30.1 30 1 abnormal rostral-caudal body axis extension 0.00144926422883967 0.0105565000563358 1.40996138179125 0.833333333333333 30.1 30 1 pale placenta 0.00144926422883967 0.0105565000563358 1.40996138179125 0.833333333333333 30.1 30 1 decreased red blood cell distribution width 0.00144926422883967 0.0105565000563358 1.40996138179125 0.833333333333333 30.1 30 1 decreased mammary gland epithelial cell proliferation 0.00144926422883967 0.0105565000563358 1.40996138179125 0.833333333333333 30.1 30 1 abnormal pulmonary valve cusp morphology 0.00144926422883967 0.0105565000563358 1.40996138179125 0.833333333333333 30.1 30 1 abnormal urethra morphology 0.0292933054852243 0.110404693021963 1.40996138179125 0.833333333333333 30.1 30 1 sparse vibrissae 0.0292933054852243 0.110404693021963 1.40996138179125 0.833333333333333 30.1 30 1 abnormal lacrimal gland physiology 0.0292933054852243 0.110404693021963 1.40996138179125 0.833333333333333 30.1 30 1 jumpy 0.0292933054852243 0.110404693021963 1.40996138179125 0.833333333333333 30.1 30 1 absent ectoplacental cone 0.0292933054852243 0.110404693021963 1.40996138179125 0.833333333333333 30.1 30 1 non-obstructive hydrocephaly 0.0292933054852243 0.110404693021963 1.40996138179125 0.833333333333333 30.1 30 1 abnormal blood gas level 0.0292933054852243 0.110404693021963 1.40996138179125 0.833333333333333 30.1 30 1 chromatolysis 0.0292933054852243 0.110404693021963 1.40996138179125 0.833333333333333 30.1 30 1 abnormal hippocampal fimbria morphology 0.0292933054852243 0.110404693021963 1.40996138179125 0.833333333333333 30.1 30 1 extremity edema 0.0292933054852243 0.110404693021963 1.40996138179125 0.833333333333333 30.1 30 1 esophageal atresia 0.0292933054852243 0.110404693021963 1.40996138179125 0.833333333333333 30.1 30 1 abnormal intestinal peristalsis 0.0292933054852243 0.110404693021963 1.40996138179125 0.833333333333333 30.1 30 1 ureter obstruction 0.0292933054852243 0.110404693021963 1.40996138179125 0.833333333333333 30.1 30 1 decreased heart right ventricle size 0.0292933054852243 0.110404693021963 1.40996138179125 0.833333333333333 30.1 30 1 abnormal milk ejection 0.0292933054852243 0.110404693021963 1.40996138179125 0.833333333333333 30.1 30 1 matted coat 0.0292933054852243 0.110404693021963 1.40996138179125 0.833333333333333 30.1 30 1 shortened QT interval 0.0292933054852243 0.110404693021963 1.40996138179125 0.833333333333333 30.1 30 1 abnormal heart left atrium morphology 0.0292933054852243 0.110404693021963 1.40996138179125 0.833333333333333 30.1 30 1 abnormal cholesterol level 0.0292933054852243 0.110404693021963 1.40996138179125 0.833333333333333 30.1 30 1 enlarged interparietal bone 0.0292933054852243 0.110404693021963 1.40996138179125 0.833333333333333 30.1 30 1 absent cochlear nerve compound action potential 0.0292933054852243 0.110404693021963 1.40996138179125 0.833333333333333 30.1 30 1 osteomyelitis 0.0292933054852243 0.110404693021963 1.40996138179125 0.833333333333333 30.1 30 1 abnormal dermis papillary layer morphology 0.0292933054852243 0.110404693021963 1.40996138179125 0.833333333333333 30.1 30 1 abnormal right lung morphology 0.0292933054852243 0.110404693021963 1.40996138179125 0.833333333333333 30.1 30 1 delayed chorioallantoic fusion 0.0292933054852243 0.110404693021963 1.40996138179125 0.833333333333333 30.1 30 1 exostosis 0.0292933054852243 0.110404693021963 1.40996138179125 0.833333333333333 30.1 30 1 enlarged lymphatic vessel 0.0292933054852243 0.110404693021963 1.40996138179125 0.833333333333333 30.1 30 1 abnormal heart right ventricle outflow tract morphology 0.0292933054852243 0.110404693021963 1.40996138179125 0.833333333333333 30.1 30 1 kidney microaneurysm 0.0292933054852243 0.110404693021963 1.40996138179125 0.833333333333333 30.1 30 1 myocardium hypoplasia 0.0292933054852243 0.110404693021963 1.40996138179125 0.833333333333333 30.1 30 1 cerebral arteriovenous malformation 0.0292933054852243 0.110404693021963 1.40996138179125 0.833333333333333 30.1 30 1 common truncal valve 0.0292933054852243 0.110404693021963 1.40996138179125 0.833333333333333 30.1 30 1 thick pulmonary valve cusps 0.0292933054852243 0.110404693021963 1.40996138179125 0.833333333333333 30.1 30 1 absent third pharyngeal arch 0.0292933054852243 0.110404693021963 1.40996138179125 0.833333333333333 30.1 30 1 abnormal intestinal enteroendocrine cell morphology 0.0292933054852243 0.110404693021963 1.40996138179125 0.833333333333333 30.1 30 1 absent alveolar lamellar bodies 0.0292933054852243 0.110404693021963 1.40996138179125 0.833333333333333 30.1 30 1 ectopic ureteric bud 0.0292933054852243 0.110404693021963 1.40996138179125 0.833333333333333 30.1 30 1 decreased macrophage nitric oxide production 0.0292933054852243 0.110404693021963 1.40996138179125 0.833333333333333 30.1 30 1 abnormal ureteric bud tip morphology 0.0292933054852243 0.110404693021963 1.40996138179125 0.833333333333333 30.1 30 1 podocyte hypertrophy 0.0292933054852243 0.110404693021963 1.40996138179125 0.833333333333333 30.1 30 1 absent midbrain 0.0292933054852243 0.110404693021963 1.40996138179125 0.833333333333333 30.1 30 1 delayed limb development 0.0292933054852243 0.110404693021963 1.40996138179125 0.833333333333333 30.1 30 1 increased bone trabecular spacing 0.0292933054852243 0.110404693021963 1.40996138179125 0.833333333333333 30.1 30 1 ectopic bone 0.0292933054852243 0.110404693021963 1.40996138179125 0.833333333333333 30.1 30 1 decreased capillary density 0.0292933054852243 0.110404693021963 1.40996138179125 0.833333333333333 30.1 30 1 decreased retinal apoptosis 0.0292933054852243 0.110404693021963 1.40996138179125 0.833333333333333 30.1 30 1 increased cardiac cell glucose uptake 0.0292933054852243 0.110404693021963 1.40996138179125 0.833333333333333 30.1 30 1 abnormal cell nucleus morphology 1.42100482706715e-10 5.89124917888256e-09 1.40396154612405 0.829787234042553 30.1 30 1 embryonic lethality between somite formation and embryo turning, complete penetrance 4.89755982762234e-15 3.99432133482314e-13 1.40190445960959 0.828571428571429 30.1 30 1 abnormal cardiovascular development 1.04454763280924e-05 0.000148900414705616 1.39770084803654 0.826086956521739 30.1 30 1 abnormal adipose tissue morphology 0.000180730778038355 0.00178399924750162 1.393373600829 0.823529411764706 30.1 30 1 abnormal interatrial septum morphology 0.000180730778038355 0.00178399924750162 1.393373600829 0.823529411764706 30.1 30 1 increased cardiomyocyte apoptosis 1.87868684012018e-07 4.30712766340916e-06 1.38432572030414 0.818181818181818 30.1 30 1 abnormal enterocyte morphology 2.33982585861595e-05 0.000305528442168356 1.38432572030414 0.818181818181818 30.1 30 1 abnormal vascular branching morphogenesis 2.33982585861595e-05 0.000305528442168356 1.38432572030414 0.818181818181818 30.1 30 1 absent semicircular canals 0.0032869029146028 0.0200396348041041 1.38432572030414 0.818181818181818 30.1 30 1 abnormal sphenoid bone morphology 0.0032869029146028 0.0200396348041041 1.38432572030414 0.818181818181818 30.1 30 1 impaired myelopoiesis 0.0032869029146028 0.0200396348041041 1.38432572030414 0.818181818181818 30.1 30 1 failure of somite differentiation 0.0032869029146028 0.0200396348041041 1.38432572030414 0.818181818181818 30.1 30 1 abnormal proximal-distal axis patterning 0.0032869029146028 0.0200396348041041 1.38432572030414 0.818181818181818 30.1 30 1 abnormal bronchiole morphology 0.0032869029146028 0.0200396348041041 1.38432572030414 0.818181818181818 30.1 30 1 fatigue 0.0032869029146028 0.0200396348041041 1.38432572030414 0.818181818181818 30.1 30 1 loss of cortex neurons 0.0032869029146028 0.0200396348041041 1.38432572030414 0.818181818181818 30.1 30 1 impaired luteinization 0.0032869029146028 0.0200396348041041 1.38432572030414 0.818181818181818 30.1 30 1 abnormal radial glial cell morphology 0.0032869029146028 0.0200396348041041 1.38432572030414 0.818181818181818 30.1 30 1 palatal shelf hypoplasia 0.0032869029146028 0.0200396348041041 1.38432572030414 0.818181818181818 30.1 30 1 common atrioventricular valve 0.0032869029146028 0.0200396348041041 1.38432572030414 0.818181818181818 30.1 30 1 decreased embryonic cilium length 0.0032869029146028 0.0200396348041041 1.38432572030414 0.818181818181818 30.1 30 1 hypolactation 0.0032869029146028 0.0200396348041041 1.38432572030414 0.818181818181818 30.1 30 1 reduced sympathetic cervical ganglion size 0.0032869029146028 0.0200396348041041 1.38432572030414 0.818181818181818 30.1 30 1 abnormal type II pneumocyte morphology 3.09800191753727e-06 5.17199984555299e-05 1.37862890664033 0.814814814814815 30.1 30 1 abnormal fetal cardiomyocyte proliferation 3.09800191753727e-06 5.17199984555299e-05 1.37862890664033 0.814814814814815 30.1 30 1 small heart 4.84700828292296e-10 1.84075314561387e-08 1.37471234724647 0.8125 30.1 30 1 abnormal spongiotrophoblast layer morphology 4.16341932877731e-07 8.38583447800289e-06 1.37471234724647 0.8125 30.1 30 1 abnormal hair follicle orientation 0.00040435725273145 0.00361812469845137 1.37471234724647 0.8125 30.1 30 1 decreased fibroblast apoptosis 0.00040435725273145 0.00361812469845137 1.37471234724647 0.8125 30.1 30 1 abnormal lung development 1.04372197853661e-16 1.05969731494278e-14 1.3734682636743 0.811764705882353 30.1 30 1 abnormal eye pigmentation 5.19468699706858e-05 0.000606656521371272 1.36967677088293 0.80952380952381 30.1 30 1 vascular ring 5.19468699706858e-05 0.000606656521371272 1.36967677088293 0.80952380952381 30.1 30 1 pericardial edema 1.82031669702192e-13 1.19158889048474e-11 1.36849192938563 0.808823529411765 30.1 30 1 thick skin 6.84383228601167e-06 0.000104122524840697 1.36657795465921 0.807692307692308 30.1 30 1 heart inflammation 6.84383228601167e-06 0.000104122524840697 1.36657795465921 0.807692307692308 30.1 30 1 abnormal Mullerian duct morphology 6.84383228601167e-06 0.000104122524840697 1.36657795465921 0.807692307692308 30.1 30 1 abnormal cell differentiation 1.69651436679414e-08 4.87870460971148e-07 1.36181635899838 0.804878048780488 30.1 30 1 small lung 3.22366275933872e-10 1.29336469578308e-08 1.3601980389045 0.803921568627451 30.1 30 1 absent mesoderm 1.35332404576969e-11 6.53668653175166e-10 1.3535629265196 0.8 30.1 30 1 abnormal liver development 2.70998821442355e-07 5.76162024220392e-06 1.3535629265196 0.8 30.1 30 1 thick pulmonary interalveolar septum 2.70998821442355e-07 5.76162024220392e-06 1.3535629265196 0.8 30.1 30 1 holoprosencephaly 2.70998821442355e-07 5.76162024220392e-06 1.3535629265196 0.8 30.1 30 1 decreased hepatocyte number 0.000893711127585575 0.00699234011954882 1.3535629265196 0.8 30.1 30 1 abnormal pericyte morphology 0.000893711127585575 0.00699234011954882 1.3535629265196 0.8 30.1 30 1 abnormal placenta size 0.000893711127585575 0.00699234011954882 1.3535629265196 0.8 30.1 30 1 liver vascular congestion 0.000893711127585575 0.00699234011954882 1.3535629265196 0.8 30.1 30 1 abnormal myocardial trabeculae morphology 5.07998831802077e-09 1.64169667058174e-07 1.3535629265196 0.8 30.1 30 1 abnormal pericardium morphology 0.00011420054835893 0.00120882495337378 1.3535629265196 0.8 30.1 30 1 abnormal response to tactile stimuli 0.00011420054835893 0.00120882495337378 1.3535629265196 0.8 30.1 30 1 increased skin tumor incidence 0.00011420054835893 0.00120882495337378 1.3535629265196 0.8 30.1 30 1 absent ductus venosus valve 0.00011420054835893 0.00120882495337378 1.3535629265196 0.8 30.1 30 1 retarded hair growth 0.00733557375896279 0.0377398960194828 1.3535629265196 0.8 30.1 30 1 abnormal respiratory mechanics 0.00733557375896279 0.0377398960194828 1.3535629265196 0.8 30.1 30 1 ketoaciduria 0.00733557375896279 0.0377398960194828 1.3535629265196 0.8 30.1 30 1 primary sex reversal 0.00733557375896279 0.0377398960194828 1.3535629265196 0.8 30.1 30 1 aneurysm 0.00733557375896279 0.0377398960194828 1.3535629265196 0.8 30.1 30 1 peritoneal inflammation 0.00733557375896279 0.0377398960194828 1.3535629265196 0.8 30.1 30 1 lymphedema 0.00733557375896279 0.0377398960194828 1.3535629265196 0.8 30.1 30 1 increased heart rate variability 0.00733557375896279 0.0377398960194828 1.3535629265196 0.8 30.1 30 1 abnormal reproductive system development 0.00733557375896279 0.0377398960194828 1.3535629265196 0.8 30.1 30 1 abnormal gas homeostasis 0.00733557375896279 0.0377398960194828 1.3535629265196 0.8 30.1 30 1 increased susceptibility to atherosclerosis 0.00733557375896279 0.0377398960194828 1.3535629265196 0.8 30.1 30 1 abnormal left subclavian artery morphology 0.00733557375896279 0.0377398960194828 1.3535629265196 0.8 30.1 30 1 thick aortic valve cusps 0.00733557375896279 0.0377398960194828 1.3535629265196 0.8 30.1 30 1 fusion of atlas and odontoid process 0.00733557375896279 0.0377398960194828 1.3535629265196 0.8 30.1 30 1 abnormal pulmonary interalveolar septum morphology 0.00733557375896279 0.0377398960194828 1.3535629265196 0.8 30.1 30 1 decreased trabecular bone connectivity density 0.00733557375896279 0.0377398960194828 1.3535629265196 0.8 30.1 30 1 decreased macrophage cytokine production 0.00733557375896279 0.0377398960194828 1.3535629265196 0.8 30.1 30 1 decreased circulating lactate level 0.00733557375896279 0.0377398960194828 1.3535629265196 0.8 30.1 30 1 increased fatty acid oxidation 0.00733557375896279 0.0377398960194828 1.3535629265196 0.8 30.1 30 1 increased mortality induced by gamma-irradiation 4.34691746363842e-06 6.95367021916436e-05 1.34189428060133 0.793103448275862 30.1 30 1 abnormal mesoderm development 4.54073438130082e-10 1.73770411899781e-08 1.34079346494866 0.792452830188679 30.1 30 1 abnormal primitive streak formation 3.25625211026823e-05 0.000412210031770597 1.33946331270169 0.791666666666667 30.1 30 1 abnormal osteoblast morphology 3.25625211026823e-05 0.000412210031770597 1.33946331270169 0.791666666666667 30.1 30 1 delayed endochondral bone ossification 2.37100796562642e-08 6.66427380169008e-07 1.33782382272286 0.790697674418605 30.1 30 1 increased hepatocellular carcinoma incidence 1.35651007670308e-10 5.71918443355748e-09 1.33575288801276 0.789473684210526 30.1 30 1 small superior vagus ganglion 0.000248348396905844 0.00238060361195871 1.33575288801276 0.789473684210526 30.1 30 1 increased liver adenoma incidence 0.000248348396905844 0.00238060361195871 1.33575288801276 0.789473684210526 30.1 30 1 decreased liver regeneration 0.000248348396905844 0.00238060361195871 1.33575288801276 0.789473684210526 30.1 30 1 small superior cervical ganglion 9.35425802857932e-06 0.000135677649248344 1.32939215997461 0.785714285714286 30.1 30 1 abnormal somite shape 9.35425802857932e-06 0.000135677649248344 1.32939215997461 0.785714285714286 30.1 30 1 increased bone resorption 9.35425802857932e-06 0.000135677649248344 1.32939215997461 0.785714285714286 30.1 30 1 hypoxia 9.35425802857932e-06 0.000135677649248344 1.32939215997461 0.785714285714286 30.1 30 1 abnormal renal tubule epithelium morphology 9.35425802857932e-06 0.000135677649248344 1.32939215997461 0.785714285714286 30.1 30 1 prolonged QRS complex duration 9.35425802857932e-06 0.000135677649248344 1.32939215997461 0.785714285714286 30.1 30 1 irregularly shaped pupil 0.00194801979520076 0.0134416067699359 1.32939215997461 0.785714285714286 30.1 30 1 increased lactate dehydrogenase level 0.00194801979520076 0.0134416067699359 1.32939215997461 0.785714285714286 30.1 30 1 increased hemangioma incidence 0.00194801979520076 0.0134416067699359 1.32939215997461 0.785714285714286 30.1 30 1 absent olfactory bulb 0.00194801979520076 0.0134416067699359 1.32939215997461 0.785714285714286 30.1 30 1 pale liver 5.08678676425773e-13 3.24445694258746e-11 1.32612584017123 0.783783783783784 30.1 30 1 malocclusion 3.69327867313745e-07 7.56134213944806e-06 1.32612584017123 0.783783783783784 30.1 30 1 abnormal branching of the mammary ductal tree 3.69327867313745e-07 7.56134213944806e-06 1.32612584017123 0.783783783783784 30.1 30 1 abnormal hematopoietic stem cell physiology 7.00282747152009e-05 0.000795412481068777 1.3241376455083 0.782608695652174 30.1 30 1 small liver 1.5226666022393e-13 1.01003551281874e-11 1.32319452752717 0.782051282051282 30.1 30 1 abnormal embryo turning 6.16866405649787e-10 2.29023161799082e-08 1.32280013273506 0.781818181818182 30.1 30 1 decreased circulating total protein level 6.16866405649787e-10 2.29023161799082e-08 1.32280013273506 0.781818181818182 30.1 30 1 increased grip strength 1.93231914692683e-15 1.6022146259935e-13 1.32009571130346 0.78021978021978 30.1 30 1 heart right ventricle hypertrophy 7.8488344240352e-07 1.48471297564925e-05 1.3159639563385 0.777777777777778 30.1 30 1 abnormal trophoblast giant cell morphology 7.8488344240352e-07 1.48471297564925e-05 1.3159639563385 0.777777777777778 30.1 30 1 cortical renal glomerulopathies 0.000533600190906594 0.00458490664898153 1.3159639563385 0.777777777777778 30.1 30 1 absent allantois 0.000533600190906594 0.00458490664898153 1.3159639563385 0.777777777777778 30.1 30 1 abnormal glycogen homeostasis 0.000533600190906594 0.00458490664898153 1.3159639563385 0.777777777777778 30.1 30 1 abnormal pregnancy 0.000533600190906594 0.00458490664898153 1.3159639563385 0.777777777777778 30.1 30 1 primary atelectasis 0.000533600190906594 0.00458490664898153 1.3159639563385 0.777777777777778 30.1 30 1 abnormal geniculate ganglion morphology 0.0160569154352232 0.0711246813615698 1.3159639563385 0.777777777777778 30.1 30 1 abnormal germ cell morphology 0.0160569154352232 0.0711246813615698 1.3159639563385 0.777777777777778 30.1 30 1 abnormal posterior semicircular canal morphology 0.0160569154352232 0.0711246813615698 1.3159639563385 0.777777777777778 30.1 30 1 abnormal lens capsule morphology 0.0160569154352232 0.0711246813615698 1.3159639563385 0.777777777777778 30.1 30 1 premature bone ossification 0.0160569154352232 0.0711246813615698 1.3159639563385 0.777777777777778 30.1 30 1 decreased fear-related response 0.0160569154352232 0.0711246813615698 1.3159639563385 0.777777777777778 30.1 30 1 decreased vestibular hair cell number 0.0160569154352232 0.0711246813615698 1.3159639563385 0.777777777777778 30.1 30 1 abnormal stria vascularis vasculature morphology 0.0160569154352232 0.0711246813615698 1.3159639563385 0.777777777777778 30.1 30 1 decreased cochlear hair cell number 0.0160569154352232 0.0711246813615698 1.3159639563385 0.777777777777778 30.1 30 1 abnormal posterior eye segment morphology 0.0160569154352232 0.0711246813615698 1.3159639563385 0.777777777777778 30.1 30 1 abnormal liver vasculature morphology 0.0160569154352232 0.0711246813615698 1.3159639563385 0.777777777777778 30.1 30 1 axonal spheroids 0.0160569154352232 0.0711246813615698 1.3159639563385 0.777777777777778 30.1 30 1 fusion of atlas and occipital bones 0.0160569154352232 0.0711246813615698 1.3159639563385 0.777777777777778 30.1 30 1 abnormal pulmonary alveolar parenchyma morphology 0.0160569154352232 0.0711246813615698 1.3159639563385 0.777777777777778 30.1 30 1 decreased bone trabecular spacing 0.0160569154352232 0.0711246813615698 1.3159639563385 0.777777777777778 30.1 30 1 abnormal infrahyoid muscle connection 0.0160569154352232 0.0711246813615698 1.3159639563385 0.777777777777778 30.1 30 1 decreased fatty acid oxidation 0.0160569154352232 0.0711246813615698 1.3159639563385 0.777777777777778 30.1 30 1 cerebellum atrophy 0.0160569154352232 0.0711246813615698 1.3159639563385 0.777777777777778 30.1 30 1 adipose tissue inflammation 0.0160569154352232 0.0711246813615698 1.3159639563385 0.777777777777778 30.1 30 1 decreased platelet dense granule number 0.0160569154352232 0.0711246813615698 1.3159639563385 0.777777777777778 30.1 30 1 abnormal extraembryonic tissue morphology 1.09330042781302e-16 1.06805066219049e-14 1.31043469601775 0.774509803921569 30.1 30 1 increased skin papilloma incidence 0.000149012148678076 0.00151602339401519 1.3074187358428 0.772727272727273 30.1 30 1 abnormal chorion morphology 0.000149012148678076 0.00151602339401519 1.3074187358428 0.772727272727273 30.1 30 1 increased adenoma incidence 0.000149012148678076 0.00151602339401519 1.3074187358428 0.772727272727273 30.1 30 1 abnormal cell morphology 2.92760107143509e-18 4.04578203621932e-16 1.30606949050137 0.771929824561403 30.1 30 1 abnormal neural tube closure 1.26667284049786e-13 8.51580727226601e-12 1.3046389653201 0.771084337349398 30.1 30 1 abnormal placenta vasculature 5.76656659891667e-09 1.85088185997487e-07 1.30150281396115 0.769230769230769 30.1 30 1 decreased circulating glycerol level 4.21654466880865e-05 0.000509583172946358 1.30150281396115 0.769230769230769 30.1 30 1 increased thymocyte apoptosis 4.21654466880865e-05 0.000509583172946358 1.30150281396115 0.769230769230769 30.1 30 1 absent common myeloid progenitor cells 0.00417884478673247 0.0250478949566193 1.30150281396115 0.769230769230769 30.1 30 1 short hair 0.00417884478673247 0.0250478949566193 1.30150281396115 0.769230769230769 30.1 30 1 abnormal coping response 0.00417884478673247 0.0250478949566193 1.30150281396115 0.769230769230769 30.1 30 1 tracheoesophageal fistula 0.00417884478673247 0.0250478949566193 1.30150281396115 0.769230769230769 30.1 30 1 increased cochlear inner hair cell number 0.00417884478673247 0.0250478949566193 1.30150281396115 0.769230769230769 30.1 30 1 kidney failure 1.40153031853401e-07 3.33617862904627e-06 1.29847606323101 0.767441860465116 30.1 30 1 pulmonary hypoplasia 4.09879127771073e-08 1.07323613719005e-06 1.29596450411451 0.765957446808511 30.1 30 1 abnormal cell cycle 7.9162910238253e-18 9.15896461477462e-16 1.29471236449701 0.765217391304348 30.1 30 1 abnormal trophoblast layer morphology 1.20196072803528e-08 3.66856111777638e-07 1.2938469150555 0.764705882352941 30.1 30 1 enlarged liver sinusoidal spaces 3.46654243570477e-06 5.65444216971515e-05 1.2938469150555 0.764705882352941 30.1 30 1 overexpanded pulmonary alveoli 3.46654243570477e-06 5.65444216971515e-05 1.2938469150555 0.764705882352941 30.1 30 1 hyperlipidemia 0.00113114329548401 0.00844960644899841 1.2938469150555 0.764705882352941 30.1 30 1 abnormal embryonic-extraembryonic boundary morphology 0.00113114329548401 0.00844960644899841 1.2938469150555 0.764705882352941 30.1 30 1 abnormal head morphology 3.53283427495393e-09 1.18755746742539e-07 1.29203733895053 0.763636363636364 30.1 30 1 decreased neuron apoptosis 1.00323941203464e-06 1.87635942664374e-05 1.29122779174567 0.763157894736842 30.1 30 1 increased incidence of induced tumors 0.000313412319201311 0.002887456088938 1.28910754906629 0.761904761904762 30.1 30 1 increased muscle cell glucose uptake 0.000313412319201311 0.002887456088938 1.28910754906629 0.761904761904762 30.1 30 1 spontaneous skin ulceration 8.81930867026746e-05 0.000977195114355915 1.28588478019362 0.76 30.1 30 1 diaphragmatic hernia 8.81930867026746e-05 0.000977195114355915 1.28588478019362 0.76 30.1 30 1 abnormal placenta morphology 2.3542559721883e-12 1.28707950127877e-10 1.28502809479709 0.759493670886076 30.1 30 1 abnormal cell adhesion 7.31036659611262e-09 2.31650151692104e-07 1.28463148118758 0.759259259259259 30.1 30 1 decreased trophoblast giant cell number 2.50916140898224e-05 0.000326782146850436 1.28355105100997 0.758620689655172 30.1 30 1 double outlet right ventricle 4.82347376183094e-16 4.36305126638344e-14 1.28082473187018 0.757009345794392 30.1 30 1 increased circulating phosphate level 2.07772300934948e-06 3.69166856125488e-05 1.28039736292395 0.756756756756757 30.1 30 1 increased bone trabecula number 6.02799273043102e-07 1.1714556185115e-05 1.2792820342106 0.75609756097561 30.1 30 1 trabecula carnea hypoplasia 1.75599723151363e-07 4.10144893276071e-06 1.2783649861574 0.755555555555556 30.1 30 1 abnormal embryonic tissue morphology 2.66864766398045e-21 6.32215339442988e-19 1.27759766023534 0.755102040816326 30.1 30 1 enlarged kidney 1.50434855976036e-08 4.41837883156535e-07 1.27694615709396 0.754716981132076 30.1 30 1 incomplete embryo turning 4.41969539208948e-09 1.47570366279498e-07 1.27638609298997 0.754385964912281 30.1 30 1 perimembraneous ventricular septal defect 1.13315239432521e-10 4.818318941682e-09 1.27509551048948 0.753623188405797 30.1 30 1 liver hypoplasia 3.07787293246613e-08 8.23248270914999e-07 1.26896524361213 0.75 30.1 30 1 abnormal kidney development 2.65876839832878e-09 8.99821277665692e-08 1.26896524361213 0.75 30.1 30 1 abnormal lysosome morphology 4.26891900857967e-06 6.85092647344641e-05 1.26896524361213 0.75 30.1 30 1 abnormal brainstem morphology 5.175418021695e-05 0.000606656521371272 1.26896524361213 0.75 30.1 30 1 abnormal nursing 0.000182425535552756 0.0017900730559664 1.26896524361213 0.75 30.1 30 1 increased mammary adenocarcinoma incidence 0.000650791942546589 0.00535155357713931 1.26896524361213 0.75 30.1 30 1 absent placental labyrinth 0.000650791942546589 0.00535155357713931 1.26896524361213 0.75 30.1 30 1 spleen atrophy 0.000650791942546589 0.00535155357713931 1.26896524361213 0.75 30.1 30 1 abnormal optic stalk morphology 0.000650791942546589 0.00535155357713931 1.26896524361213 0.75 30.1 30 1 failure of tooth eruption 0.00236177275214795 0.0157504282063486 1.26896524361213 0.75 30.1 30 1 vasculature congestion 0.00236177275214795 0.0157504282063486 1.26896524361213 0.75 30.1 30 1 disorganized yolk sac vascular plexus 0.00236177275214795 0.0157504282063486 1.26896524361213 0.75 30.1 30 1 abnormal epicardium morphology 0.00236177275214795 0.0157504282063486 1.26896524361213 0.75 30.1 30 1 increased cochlear outer hair cell number 0.00236177275214795 0.0157504282063486 1.26896524361213 0.75 30.1 30 1 decreased creatinine clearance 0.00236177275214795 0.0157504282063486 1.26896524361213 0.75 30.1 30 1 impaired somite development 0.00236177275214795 0.0157504282063486 1.26896524361213 0.75 30.1 30 1 decreased liver cholesterol level 0.00236177275214795 0.0157504282063486 1.26896524361213 0.75 30.1 30 1 increased heart left ventricle size 0.00236177275214795 0.0157504282063486 1.26896524361213 0.75 30.1 30 1 abnormal pulmonary alveolus wall morphology 0.00236177275214795 0.0157504282063486 1.26896524361213 0.75 30.1 30 1 abnormal adipose tissue distribution 0.00879981897189219 0.0440877133788154 1.26896524361213 0.75 30.1 30 1 amyloidosis 0.00879981897189219 0.0440877133788154 1.26896524361213 0.75 30.1 30 1 abnormal superior cervical ganglion morphology 0.00879981897189219 0.0440877133788154 1.26896524361213 0.75 30.1 30 1 impaired embryo implantation 0.00879981897189219 0.0440877133788154 1.26896524361213 0.75 30.1 30 1 abnormal thymus involution 0.00879981897189219 0.0440877133788154 1.26896524361213 0.75 30.1 30 1 increased papilloma incidence 0.00879981897189219 0.0440877133788154 1.26896524361213 0.75 30.1 30 1 abnormal embryonic growth/weight/body size 0.00879981897189219 0.0440877133788154 1.26896524361213 0.75 30.1 30 1 abnormal gastrocnemius morphology 0.00879981897189219 0.0440877133788154 1.26896524361213 0.75 30.1 30 1 abnormal vascular endothelial cell development 0.00879981897189219 0.0440877133788154 1.26896524361213 0.75 30.1 30 1 decreased cochlear nerve compound action potential 0.00879981897189219 0.0440877133788154 1.26896524361213 0.75 30.1 30 1 abnormal fatty acid level 0.00879981897189219 0.0440877133788154 1.26896524361213 0.75 30.1 30 1 abnormal thymus corticomedullary boundary morphology 0.00879981897189219 0.0440877133788154 1.26896524361213 0.75 30.1 30 1 increased fibrosarcoma incidence 0.00879981897189219 0.0440877133788154 1.26896524361213 0.75 30.1 30 1 persistent right dorsal aorta 0.00879981897189219 0.0440877133788154 1.26896524361213 0.75 30.1 30 1 abnormal exoccipital bone morphology 0.0343210038641124 0.12101133538197 1.26896524361213 0.75 30.1 30 1 failure of vascular branching 0.0343210038641124 0.12101133538197 1.26896524361213 0.75 30.1 30 1 schistocytosis 0.0343210038641124 0.12101133538197 1.26896524361213 0.75 30.1 30 1 absent eyelids 0.0343210038641124 0.12101133538197 1.26896524361213 0.75 30.1 30 1 abnormal urination 0.0343210038641124 0.12101133538197 1.26896524361213 0.75 30.1 30 1 abnormal hepatobiliary system morphology 0.0343210038641124 0.12101133538197 1.26896524361213 0.75 30.1 30 1 abnormal secondary sex determination 0.0343210038641124 0.12101133538197 1.26896524361213 0.75 30.1 30 1 abnormal thyroid physiology 0.0343210038641124 0.12101133538197 1.26896524361213 0.75 30.1 30 1 short ureter 0.0343210038641124 0.12101133538197 1.26896524361213 0.75 30.1 30 1 decreased aerobic running capacity 0.0343210038641124 0.12101133538197 1.26896524361213 0.75 30.1 30 1 hypospadia 0.0343210038641124 0.12101133538197 1.26896524361213 0.75 30.1 30 1 abnormal neuron apoptosis 0.0343210038641124 0.12101133538197 1.26896524361213 0.75 30.1 30 1 colon polyps 0.0343210038641124 0.12101133538197 1.26896524361213 0.75 30.1 30 1 liver failure 0.0343210038641124 0.12101133538197 1.26896524361213 0.75 30.1 30 1 liver cysts 0.0343210038641124 0.12101133538197 1.26896524361213 0.75 30.1 30 1 binucleate 0.0343210038641124 0.12101133538197 1.26896524361213 0.75 30.1 30 1 tau protein deposits 0.0343210038641124 0.12101133538197 1.26896524361213 0.75 30.1 30 1 thin stria vascularis 0.0343210038641124 0.12101133538197 1.26896524361213 0.75 30.1 30 1 bowed fibula 0.0343210038641124 0.12101133538197 1.26896524361213 0.75 30.1 30 1 absent interparietal bone 0.0343210038641124 0.12101133538197 1.26896524361213 0.75 30.1 30 1 accumulation of giant lysosomes in kidney/renal tubule cells 0.0343210038641124 0.12101133538197 1.26896524361213 0.75 30.1 30 1 abnormal choroid pigmentation 0.0343210038641124 0.12101133538197 1.26896524361213 0.75 30.1 30 1 non-pigmented tail tip 0.0343210038641124 0.12101133538197 1.26896524361213 0.75 30.1 30 1 Sertoli cell hypoplasia 0.0343210038641124 0.12101133538197 1.26896524361213 0.75 30.1 30 1 abnormal mitotic spindle assembly checkpoint 0.0343210038641124 0.12101133538197 1.26896524361213 0.75 30.1 30 1 abnormal sphingomyelin level 0.0343210038641124 0.12101133538197 1.26896524361213 0.75 30.1 30 1 skin fibrosis 0.0343210038641124 0.12101133538197 1.26896524361213 0.75 30.1 30 1 decreased hippocampus pyramidal cell number 0.0343210038641124 0.12101133538197 1.26896524361213 0.75 30.1 30 1 increased caudal vertebrae number 0.0343210038641124 0.12101133538197 1.26896524361213 0.75 30.1 30 1 pleural effusion 0.0343210038641124 0.12101133538197 1.26896524361213 0.75 30.1 30 1 pulmonary artery hypoplasia 0.0343210038641124 0.12101133538197 1.26896524361213 0.75 30.1 30 1 increased heart right ventricle size 0.0343210038641124 0.12101133538197 1.26896524361213 0.75 30.1 30 1 impaired mucociliary clearance 0.0343210038641124 0.12101133538197 1.26896524361213 0.75 30.1 30 1 abnormal stomach position or orientation 0.0343210038641124 0.12101133538197 1.26896524361213 0.75 30.1 30 1 decreased lung compliance 0.0343210038641124 0.12101133538197 1.26896524361213 0.75 30.1 30 1 abnormal pulmonary acinus morphology 0.0343210038641124 0.12101133538197 1.26896524361213 0.75 30.1 30 1 abnormal maxillary prominence morphology 0.0343210038641124 0.12101133538197 1.26896524361213 0.75 30.1 30 1 abnormal foramen magnum morphology 0.0343210038641124 0.12101133538197 1.26896524361213 0.75 30.1 30 1 abnormal bronchus epithelium morphology 0.0343210038641124 0.12101133538197 1.26896524361213 0.75 30.1 30 1 abnormal branching involved in ureteric bud morphogenesis 0.0343210038641124 0.12101133538197 1.26896524361213 0.75 30.1 30 1 increased aorta wall thickness 0.0343210038641124 0.12101133538197 1.26896524361213 0.75 30.1 30 1 abnormal macrophage activation involved in immune response 0.0343210038641124 0.12101133538197 1.26896524361213 0.75 30.1 30 1 lethality during fetal growth through weaning, incomplete penetrance 0.0343210038641124 0.12101133538197 1.26896524361213 0.75 30.1 30 1 abnormal heart echocardiography feature 0.0343210038641124 0.12101133538197 1.26896524361213 0.75 30.1 30 1 absent hypoglossal canal 0.0343210038641124 0.12101133538197 1.26896524361213 0.75 30.1 30 1 retropleural edema 0.0343210038641124 0.12101133538197 1.26896524361213 0.75 30.1 30 1 lethality throughout fetal growth and development, incomplete penetrance 8.61702397044032e-25 3.06212101806718e-22 1.26660217984376 0.748603351955307 30.1 30 1 abnormal hepatocyte morphology 7.41180441380225e-16 6.58459409976182e-14 1.26515453717485 0.747747747747748 30.1 30 1 pale yolk sac 3.61223402481516e-12 1.93235099714574e-10 1.26386899765384 0.746987951807229 30.1 30 1 abnormal gluconeogenesis 6.25948811586435e-08 1.5969719680218e-06 1.260671353131 0.745098039215686 30.1 30 1 increased cellular sensitivity to gamma-irradiation 2.13794447528308e-07 4.81279355861236e-06 1.25996549011133 0.74468085106383 30.1 30 1 abnormal heart looping 2.5183227992748e-06 4.38064892531194e-05 1.25811938682912 0.743589743589744 30.1 30 1 abnormal embryo size 9.02974256213094e-16 7.88122267484236e-14 1.2577354626952 0.743362831858407 30.1 30 1 kidney cysts 8.31861065087396e-11 3.59870330331286e-09 1.2575331243003 0.743243243243243 30.1 30 1 abnormal postnatal growth/weight/body size 3.02033068005597e-05 0.000388045394019798 1.2553204560464 0.741935483870968 30.1 30 1 preaxial polydactyly 3.02033068005597e-05 0.000388045394019798 1.2553204560464 0.741935483870968 30.1 30 1 abnormal embryonic neuroepithelium morphology 1.09262797705969e-08 3.35544702831601e-07 1.25437943621428 0.741379310344828 30.1 30 1 abnormal apoptosis 3.71381113161495e-08 9.84555163261839e-07 1.25329900603667 0.740740740740741 30.1 30 1 abnormal atrioventricular cushion morphology 0.000105626041294985 0.00113008506546785 1.25329900603667 0.740740740740741 30.1 30 1 abnormal bone trabecula morphology 0.000105626041294985 0.00113008506546785 1.25329900603667 0.740740740740741 30.1 30 1 increased B cell derived lymphoma incidence 1.26502441719422e-07 3.08504729193197e-06 1.25204570703063 0.74 30.1 30 1 abnormal cell death 4.31990869959113e-07 8.66594587922012e-06 1.25057444298007 0.739130434782609 30.1 30 1 fragile skeleton 0.000372799791572887 0.00334779596222945 1.25057444298007 0.739130434782609 30.1 30 1 delayed sexual maturation 0.00133230521410869 0.00987811988105918 1.24670269547858 0.736842105263158 30.1 30 1 increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 0.00133230521410869 0.00987811988105918 1.24670269547858 0.736842105263158 30.1 30 1 embryonic lethality, complete penetrance 1.96672243751148e-40 1.08716045851329e-37 1.24642354127001 0.736677115987461 30.1 30 1 decreased embryo size 6.53078699347583e-60 6.49813305850845e-57 1.2459575055829 0.736401673640167 30.1 30 1 hydrops fetalis 3.35812064736892e-10 1.32592462068733e-08 1.24546588724894 0.736111111111111 30.1 30 1 abnormal forebrain development 3.35812064736892e-10 1.32592462068733e-08 1.24546588724894 0.736111111111111 30.1 30 1 extramedullary hematopoiesis 2.44847604042916e-14 1.79810089680751e-12 1.24502250316661 0.735849056603774 30.1 30 1 lung hemorrhage 1.75613736590346e-05 0.000237412592265481 1.24408357216875 0.735294117647059 30.1 30 1 abnormal direction of heart looping 1.75613736590346e-05 0.000237412592265481 1.24408357216875 0.735294117647059 30.1 30 1 abnormal placenta labyrinth morphology 5.90725409651245e-11 2.60076010001323e-09 1.24219382497052 0.734177215189873 30.1 30 1 abnormal erythropoiesis 4.88086216218654e-14 3.3725401745664e-12 1.2407660159763 0.733333333333333 30.1 30 1 placental labyrinth hypoplasia 0.00484736863114252 0.028438277051809 1.2407660159763 0.733333333333333 30.1 30 1 abnormal cricoid cartilage morphology 0.00484736863114252 0.028438277051809 1.2407660159763 0.733333333333333 30.1 30 1 abnormal bronchus morphology 0.00484736863114252 0.028438277051809 1.2407660159763 0.733333333333333 30.1 30 1 abnormal glial cell morphology 0.00484736863114252 0.028438277051809 1.2407660159763 0.733333333333333 30.1 30 1 decreased thymocyte apoptosis 0.00484736863114252 0.028438277051809 1.2407660159763 0.733333333333333 30.1 30 1 lactation failure 0.00484736863114252 0.028438277051809 1.2407660159763 0.733333333333333 30.1 30 1 abnormal ectoderm development 8.66686974539675e-07 1.63324534027836e-05 1.2407660159763 0.733333333333333 30.1 30 1 decreased susceptibility to hepatic steatosis 7.62500639558544e-09 2.40091182392643e-07 1.23539473452186 0.73015873015873 30.1 30 1 abnormal angiogenesis 3.95235012210737e-10 1.53616733261595e-08 1.23466888567666 0.72972972972973 30.1 30 1 decreased circulating calcium level 8.71780352995795e-08 2.15776480405676e-06 1.23051175138145 0.727272727272727 30.1 30 1 abnormal rostral-caudal axis patterning 8.71780352995795e-08 2.15776480405676e-06 1.23051175138145 0.727272727272727 30.1 30 1 abnormal astrocyte morphology 1.72586365233301e-06 3.110931764622e-05 1.23051175138145 0.727272727272727 30.1 30 1 enlarged pericardium 3.51225646427566e-05 0.00043466357984506 1.23051175138145 0.727272727272727 30.1 30 1 abnormal germ layer development 0.000751812773929934 0.00612155245548514 1.23051175138145 0.727272727272727 30.1 30 1 increased myocardial infarction size 0.000751812773929934 0.00612155245548514 1.23051175138145 0.727272727272727 30.1 30 1 pulmonary vascular congestion 0.000751812773929934 0.00612155245548514 1.23051175138145 0.727272727272727 30.1 30 1 embryonic lethality before implantation, incomplete penetrance 0.000751812773929934 0.00612155245548514 1.23051175138145 0.727272727272727 30.1 30 1 premature suture closure 0.0181320293439227 0.0783045538073052 1.23051175138145 0.727272727272727 30.1 30 1 decreased atrioventricular cushion size 0.0181320293439227 0.0783045538073052 1.23051175138145 0.727272727272727 30.1 30 1 abnormal large intestine morphology 0.0181320293439227 0.0783045538073052 1.23051175138145 0.727272727272727 30.1 30 1 abnormal eye distance/ position 0.0181320293439227 0.0783045538073052 1.23051175138145 0.727272727272727 30.1 30 1 abnormal food preference 0.0181320293439227 0.0783045538073052 1.23051175138145 0.727272727272727 30.1 30 1 abnormal hemoglobin 0.0181320293439227 0.0783045538073052 1.23051175138145 0.727272727272727 30.1 30 1 secondary sex reversal 0.0181320293439227 0.0783045538073052 1.23051175138145 0.727272727272727 30.1 30 1 abnormal larynx morphology 0.0181320293439227 0.0783045538073052 1.23051175138145 0.727272727272727 30.1 30 1 retinal detachment 0.0181320293439227 0.0783045538073052 1.23051175138145 0.727272727272727 30.1 30 1 dilated renal glomerular capsule 0.0181320293439227 0.0783045538073052 1.23051175138145 0.727272727272727 30.1 30 1 abnormal hair medulla 0.0181320293439227 0.0783045538073052 1.23051175138145 0.727272727272727 30.1 30 1 pharyngeal arch hypoplasia 0.0181320293439227 0.0783045538073052 1.23051175138145 0.727272727272727 30.1 30 1 abnormal spinal cord ventral horn morphology 0.0181320293439227 0.0783045538073052 1.23051175138145 0.727272727272727 30.1 30 1 abnormal superovulation 0.0181320293439227 0.0783045538073052 1.23051175138145 0.727272727272727 30.1 30 1 abnormal palatal shelf elevation 0.0181320293439227 0.0783045538073052 1.23051175138145 0.727272727272727 30.1 30 1 aorta dilation 0.0181320293439227 0.0783045538073052 1.23051175138145 0.727272727272727 30.1 30 1 abnormal eye morphology 1.69700676679456e-17 1.8761352588451e-15 1.22940517606546 0.726618705035971 30.1 30 1 embryonic lethality between implantation and somite formation, complete penetrance 1.03661474221111e-29 4.29763195208355e-27 1.22925612714535 0.726530612244898 30.1 30 1 prenatal lethality 1.50979779169067e-08 4.41837883156535e-07 1.22803088091496 0.725806451612903 30.1 30 1 abnormal gastrulation 2.95400994630052e-07 6.20092805183337e-06 1.2274957912065 0.725490196078431 30.1 30 1 failure of chorioallantoic fusion 2.95400994630052e-07 6.20092805183337e-06 1.2274957912065 0.725490196078431 30.1 30 1 embryonic lethality during organogenesis, complete penetrance 9.39393211834475e-66 1.16837030721913e-62 1.22666640215839 0.725 30.1 30 1 perinatal lethality 5.8968325416001e-06 9.1677318420189e-05 1.22666640215839 0.725 30.1 30 1 abnormal embryonic erythropoiesis 0.00012174341630066 0.00128049364925113 1.2252078214186 0.724137931034483 30.1 30 1 abnormal blood vessel morphology 5.92473354800205e-18 7.18915839056346e-16 1.2252078214186 0.724137931034483 30.1 30 1 abnormal lung morphology 6.968337697981e-15 5.50277461070722e-13 1.22275642521729 0.722689075630252 30.1 30 1 abnormal pharyngeal arch morphology 2.02111244045054e-05 0.000268134250433105 1.22196653088575 0.722222222222222 30.1 30 1 narrow eye opening 2.02111244045054e-05 0.000268134250433105 1.22196653088575 0.722222222222222 30.1 30 1 abnormal bile duct morphology 0.00268475536738529 0.0174141563921015 1.22196653088575 0.722222222222222 30.1 30 1 abnormal redox activity 0.00268475536738529 0.0174141563921015 1.22196653088575 0.722222222222222 30.1 30 1 decreased cellular sensitivity to gamma-irradiation 0.00268475536738529 0.0174141563921015 1.22196653088575 0.722222222222222 30.1 30 1 increased circulating renin level 0.00268475536738529 0.0174141563921015 1.22196653088575 0.722222222222222 30.1 30 1 jerky movement 0.00268475536738529 0.0174141563921015 1.22196653088575 0.722222222222222 30.1 30 1 increased gastrointestinal tumor incidence 0.00268475536738529 0.0174141563921015 1.22196653088575 0.722222222222222 30.1 30 1 abnormal vitelline vasculature morphology 2.32028806027785e-14 1.74900501513369e-12 1.22114916196877 0.721739130434783 30.1 30 1 increased circulating creatinine level 4.71501217826379e-11 2.1520353749415e-09 1.21978054424731 0.720930232558139 30.1 30 1 delayed bone ossification 9.00197173876696e-10 3.26896418980771e-08 1.21820663386764 0.72 30.1 30 1 ruffled hair 0.000424737546881539 0.00378686253716067 1.21820663386764 0.72 30.1 30 1 abnormal thyroid gland morphology 0.000424737546881539 0.00378686253716067 1.21820663386764 0.72 30.1 30 1 anophthalmia 2.76284487396343e-11 1.29671257056302e-09 1.21668577664683 0.719101123595506 30.1 30 1 scoliosis 6.9532949837667e-05 0.000791593650897926 1.21609169179495 0.71875 30.1 30 1 failure of primitive streak formation 6.9532949837667e-05 0.000791593650897926 1.21609169179495 0.71875 30.1 30 1 increased fibroblast apoptosis 6.9532949837667e-05 0.000791593650897926 1.21609169179495 0.71875 30.1 30 1 abnormal craniofacial morphology 8.5535433495733e-13 5.2535652054478e-11 1.21557835634042 0.718446601941748 30.1 30 1 failure of heart looping 1.16228879828832e-05 0.000162884134408011 1.21473595969708 0.717948717948718 30.1 30 1 embryonic lethality between implantation and placentation, complete penetrance 1.9701463169365e-06 3.53843968475057e-05 1.21379284171595 0.717391304347826 30.1 30 1 decreased circulating serum albumin level 2.84518127619476e-12 1.53856270098575e-10 1.21342131039005 0.717171717171717 30.1 30 1 abnormal placenta development 3.37281982900655e-07 7.02642864579513e-06 1.21309884923926 0.716981132075472 30.1 30 1 increased circulating alkaline phosphatase level 4.80698432213214e-19 7.47335843831481e-17 1.21152237250211 0.716049382716049 30.1 30 1 edema 4.9980436285058e-20 8.88045251850584e-18 1.20994360437435 0.715116279069767 30.1 30 1 lymphoid hyperplasia 0.000240305693990073 0.00231690082868336 1.20853832724964 0.714285714285714 30.1 30 1 abnormal mitotic spindle morphology 0.000240305693990073 0.00231690082868336 1.20853832724964 0.714285714285714 30.1 30 1 abnormal erythrocyte physiology 0.00149424100090978 0.0108050130516369 1.20853832724964 0.714285714285714 30.1 30 1 complete atrioventricular septal defect 0.00149424100090978 0.0108050130516369 1.20853832724964 0.714285714285714 30.1 30 1 absent segment of posterior cerebral artery 0.00149424100090978 0.0108050130516369 1.20853832724964 0.714285714285714 30.1 30 1 abnormal blood flow velocity 0.00975590726556172 0.0479127726023391 1.20853832724964 0.714285714285714 30.1 30 1 megacephaly 0.00975590726556172 0.0479127726023391 1.20853832724964 0.714285714285714 30.1 30 1 abnormal kidney blood vessel morphology 0.00975590726556172 0.0479127726023391 1.20853832724964 0.714285714285714 30.1 30 1 absent visceral yolk sac blood islands 0.00975590726556172 0.0479127726023391 1.20853832724964 0.714285714285714 30.1 30 1 abnormal fluid regulation 0.00975590726556172 0.0479127726023391 1.20853832724964 0.714285714285714 30.1 30 1 abnormal spleen periarteriolar lymphoid sheath morphology 0.00975590726556172 0.0479127726023391 1.20853832724964 0.714285714285714 30.1 30 1 failure of zygotic cell division 0.00975590726556172 0.0479127726023391 1.20853832724964 0.714285714285714 30.1 30 1 abnormal vascular endothelial cell migration 0.00975590726556172 0.0479127726023391 1.20853832724964 0.714285714285714 30.1 30 1 increased circulating growth hormone level 0.00975590726556172 0.0479127726023391 1.20853832724964 0.714285714285714 30.1 30 1 abnormal viscerocranium morphology 0.00975590726556172 0.0479127726023391 1.20853832724964 0.714285714285714 30.1 30 1 abnormal renal tubule epithelial cell primary cilium morphology 0.00975590726556172 0.0479127726023391 1.20853832724964 0.714285714285714 30.1 30 1 multiple persisting craniopharyngeal ducts 0.00975590726556172 0.0479127726023391 1.20853832724964 0.714285714285714 30.1 30 1 abnormal vitelline vein topology 0.00975590726556172 0.0479127726023391 1.20853832724964 0.714285714285714 30.1 30 1 growth retardation of molars 0.0712015005987045 0.197671576717944 1.20853832724964 0.714285714285714 30.1 30 1 failure of atrioventricular cushion closure 0.0712015005987045 0.197671576717944 1.20853832724964 0.714285714285714 30.1 30 1 absent hair follicles 0.0712015005987045 0.197671576717944 1.20853832724964 0.714285714285714 30.1 30 1 maxilla hypoplasia 0.0712015005987045 0.197671576717944 1.20853832724964 0.714285714285714 30.1 30 1 small L4 dorsal root ganglion 0.0712015005987045 0.197671576717944 1.20853832724964 0.714285714285714 30.1 30 1 abnormal oculomotor nerve morphology 0.0712015005987045 0.197671576717944 1.20853832724964 0.714285714285714 30.1 30 1 absent epidermis stratum corneum 0.0712015005987045 0.197671576717944 1.20853832724964 0.714285714285714 30.1 30 1 limp posture 0.0712015005987045 0.197671576717944 1.20853832724964 0.714285714285714 30.1 30 1 abnormal circulating free fatty acids level 0.0712015005987045 0.197671576717944 1.20853832724964 0.714285714285714 30.1 30 1 abnormal circulating alanine transaminase level 0.0712015005987045 0.197671576717944 1.20853832724964 0.714285714285714 30.1 30 1 decreased mortality induced by ionizing radiation 0.0712015005987045 0.197671576717944 1.20853832724964 0.714285714285714 30.1 30 1 detached tectorial membrane 0.0712015005987045 0.197671576717944 1.20853832724964 0.714285714285714 30.1 30 1 absent tunnel of Corti 0.0712015005987045 0.197671576717944 1.20853832724964 0.714285714285714 30.1 30 1 decreased cardiomyocyte apoptosis 0.0712015005987045 0.197671576717944 1.20853832724964 0.714285714285714 30.1 30 1 increased cell nucleus count 0.0712015005987045 0.197671576717944 1.20853832724964 0.714285714285714 30.1 30 1 renal necrosis 0.0712015005987045 0.197671576717944 1.20853832724964 0.714285714285714 30.1 30 1 absent vestibular hair cells 0.0712015005987045 0.197671576717944 1.20853832724964 0.714285714285714 30.1 30 1 absent ulna 0.0712015005987045 0.197671576717944 1.20853832724964 0.714285714285714 30.1 30 1 abnormal strial marginal cell morphology 0.0712015005987045 0.197671576717944 1.20853832724964 0.714285714285714 30.1 30 1 absent endocochlear potential 0.0712015005987045 0.197671576717944 1.20853832724964 0.714285714285714 30.1 30 1 abnormal talus morphology 0.0712015005987045 0.197671576717944 1.20853832724964 0.714285714285714 30.1 30 1 absent thyroid gland 0.0712015005987045 0.197671576717944 1.20853832724964 0.714285714285714 30.1 30 1 absent fibula 0.0712015005987045 0.197671576717944 1.20853832724964 0.714285714285714 30.1 30 1 increased chronic myelocytic leukemia incidence 0.0712015005987045 0.197671576717944 1.20853832724964 0.714285714285714 30.1 30 1 decreased tidal volume 0.0712015005987045 0.197671576717944 1.20853832724964 0.714285714285714 30.1 30 1 increased keratinocyte apoptosis 0.0712015005987045 0.197671576717944 1.20853832724964 0.714285714285714 30.1 30 1 uremia 0.0712015005987045 0.197671576717944 1.20853832724964 0.714285714285714 30.1 30 1 abnormal spinal cord central canal morphology 0.0712015005987045 0.197671576717944 1.20853832724964 0.714285714285714 30.1 30 1 enhanced behavioral response to alcohol 0.0712015005987045 0.197671576717944 1.20853832724964 0.714285714285714 30.1 30 1 abnormal sperm annulus morphology 0.0712015005987045 0.197671576717944 1.20853832724964 0.714285714285714 30.1 30 1 decreased DN4 thymocyte number 0.0712015005987045 0.197671576717944 1.20853832724964 0.714285714285714 30.1 30 1 focal dorsal hair loss 0.0712015005987045 0.197671576717944 1.20853832724964 0.714285714285714 30.1 30 1 decreased skeletal muscle glycogen level 0.0712015005987045 0.197671576717944 1.20853832724964 0.714285714285714 30.1 30 1 heart right ventricle outflow tract stenosis 0.0712015005987045 0.197671576717944 1.20853832724964 0.714285714285714 30.1 30 1 coronary fistula 0.0712015005987045 0.197671576717944 1.20853832724964 0.714285714285714 30.1 30 1 abnormal T wave 0.0712015005987045 0.197671576717944 1.20853832724964 0.714285714285714 30.1 30 1 thick pulmonary valve 0.0712015005987045 0.197671576717944 1.20853832724964 0.714285714285714 30.1 30 1 thick mitral valve cusps 0.0712015005987045 0.197671576717944 1.20853832724964 0.714285714285714 30.1 30 1 small lung saccule 0.0712015005987045 0.197671576717944 1.20853832724964 0.714285714285714 30.1 30 1 increased circulating lactate dehydrogenase level 0.0712015005987045 0.197671576717944 1.20853832724964 0.714285714285714 30.1 30 1 parturition failure 0.0712015005987045 0.197671576717944 1.20853832724964 0.714285714285714 30.1 30 1 decreased areal bone mineral density 0.0712015005987045 0.197671576717944 1.20853832724964 0.714285714285714 30.1 30 1 ductus venosus stenosis 0.0712015005987045 0.197671576717944 1.20853832724964 0.714285714285714 30.1 30 1 abnormal Mullerian duct topology 0.0712015005987045 0.197671576717944 1.20853832724964 0.714285714285714 30.1 30 1 absent connection between subcutaneous lymph vessels and lymph sac 0.0712015005987045 0.197671576717944 1.20853832724964 0.714285714285714 30.1 30 1 abnormal craniofacial development 1.13762612382649e-06 2.11973406967669e-05 1.20853832724964 0.714285714285714 30.1 30 1 increased carcinoma incidence 3.9721534315779e-05 0.000485539639363638 1.20853832724964 0.714285714285714 30.1 30 1 abnormal artery morphology 3.9721534315779e-05 0.000485539639363638 1.20853832724964 0.714285714285714 30.1 30 1 abnormal midbrain development 3.9721534315779e-05 0.000485539639363638 1.20853832724964 0.714285714285714 30.1 30 1 abnormal embryonic epiblast morphology 3.9721534315779e-05 0.000485539639363638 1.20853832724964 0.714285714285714 30.1 30 1 abnormal vascular development 1.96053718744091e-08 5.60555891236698e-07 1.20487608989434 0.712121212121212 30.1 30 1 small placenta 3.84076008997814e-06 6.18374804130784e-05 1.2031670457952 0.711111111111111 30.1 30 1 persistence of hyaloid vascular system 2.27005591488731e-05 0.000297982273787978 1.20217759921149 0.710526315789474 30.1 30 1 abnormal compact bone morphology 2.27005591488731e-05 0.000297982273787978 1.20217759921149 0.710526315789474 30.1 30 1 abnormal liver physiology 6.24086210156515e-12 3.20085453147285e-10 1.20128709728614 0.71 30.1 30 1 abnormal neural tube morphology 2.03986953359597e-18 2.89952883703998e-16 1.20107821411847 0.709876543209877 30.1 30 1 inner cell mass degeneration 0.000136165118522077 0.00141719971683542 1.20074130578352 0.709677419354839 30.1 30 1 increased oxygen consumption 2.01889646530494e-10 8.30083464040666e-09 1.20010666450139 0.709302325581395 30.1 30 1 abnormal somite development 1.1521336032653e-09 4.03652441989074e-08 1.19935955514395 0.708860759493671 30.1 30 1 abnormal myocardium layer morphology 1.1521336032653e-09 4.03652441989074e-08 1.19935955514395 0.708860759493671 30.1 30 1 overriding aortic valve 2.20772528120723e-06 3.89483449432835e-05 1.19846717452256 0.708333333333333 30.1 30 1 decreased body height 0.000835137270478918 0.00667975549940935 1.19846717452256 0.708333333333333 30.1 30 1 ocular hypertelorism 0.000835137270478918 0.00667975549940935 1.19846717452256 0.708333333333333 30.1 30 1 hemolytic anemia 0.000835137270478918 0.00667975549940935 1.19846717452256 0.708333333333333 30.1 30 1 decreased fatty acid level 0.000835137270478918 0.00667975549940935 1.19846717452256 0.708333333333333 30.1 30 1 increased body temperature 0.000835137270478918 0.00667975549940935 1.19846717452256 0.708333333333333 30.1 30 1 abnormal truncus arteriosus septation 0.000835137270478918 0.00667975549940935 1.19846717452256 0.708333333333333 30.1 30 1 abnormal developmental patterning 6.68947987830167e-10 2.46519721441117e-08 1.19674770942282 0.707317073170732 30.1 30 1 thick ventricular wall 1.29797646156068e-05 0.000179872782625749 1.19674770942282 0.707317073170732 30.1 30 1 increased mean corpuscular hemoglobin 1.20104305515028e-11 5.91602891026996e-10 1.19633086939864 0.707070707070707 30.1 30 1 glomerulosclerosis 2.18614953795891e-07 4.87717217549129e-06 1.19603620662292 0.706896551724138 30.1 30 1 decreased mean corpuscular hemoglobin 2.19110083615922e-08 6.19359469312052e-07 1.194320229282 0.705882352941177 30.1 30 1 abnormal brown adipose tissue morphology 7.72694230036895e-05 0.0008716902028194 1.194320229282 0.705882352941177 30.1 30 1 abnormal bone marrow cavity morphology 0.00531528344814142 0.0299813323747206 1.194320229282 0.705882352941177 30.1 30 1 hydroureter 0.00531528344814142 0.0299813323747206 1.194320229282 0.705882352941177 30.1 30 1 abnormal vagus nerve morphology 0.00531528344814142 0.0299813323747206 1.194320229282 0.705882352941177 30.1 30 1 abnormal cranial suture morphology 0.00531528344814142 0.0299813323747206 1.194320229282 0.705882352941177 30.1 30 1 decreased vasoconstriction 0.00531528344814142 0.0299813323747206 1.194320229282 0.705882352941177 30.1 30 1 enhanced behavioral response to cocaine 0.00531528344814142 0.0299813323747206 1.194320229282 0.705882352941177 30.1 30 1 increased hepatoma incidence 0.00531528344814142 0.0299813323747206 1.194320229282 0.705882352941177 30.1 30 1 common atrium 0.00531528344814142 0.0299813323747206 1.194320229282 0.705882352941177 30.1 30 1 increased trabecular bone mass 0.00531528344814142 0.0299813323747206 1.194320229282 0.705882352941177 30.1 30 1 delayed heart development 0.00531528344814142 0.0299813323747206 1.194320229282 0.705882352941177 30.1 30 1 embryonic lethality during organogenesis, incomplete penetrance 9.57519175665785e-25 3.17577193262485e-22 1.19172388095747 0.704347826086957 30.1 30 1 abnormal skeletal muscle fiber morphology 1.26713066193344e-08 3.82059093522354e-07 1.19151666066866 0.704225352112676 30.1 30 1 polydactyly 2.30204716771445e-11 1.09073187232184e-09 1.19127349400322 0.704081632653061 30.1 30 1 abnormal small intestine morphology 7.29716606741987e-07 1.39093491131854e-05 1.19063405573483 0.703703703703704 30.1 30 1 abnormal skin appearance 0.000468435878965287 0.00414674109938132 1.19063405573483 0.703703703703704 30.1 30 1 decreased erythrocyte cell number 5.24649755045231e-17 5.5534734709575e-15 1.18544523819392 0.700636942675159 30.1 30 1 preweaning lethality, complete penetrance 5.53246650314983e-75 1.37620104265852e-71 1.18436756070465 0.7 30.1 30 1 lethality throughout fetal growth and development, complete penetrance 3.3780678139106e-20 6.24042190585263e-18 1.18436756070465 0.7 30.1 30 1 abnormal incisor morphology 2.41375746704444e-07 5.19846034569095e-06 1.18436756070465 0.7 30.1 30 1 short stride length 2.43455365994081e-06 4.24979103796686e-05 1.18436756070465 0.7 30.1 30 1 decreased circulating alkaline phosphatase level 2.43455365994081e-06 4.24979103796686e-05 1.18436756070465 0.7 30.1 30 1 abnormal optic cup morphology 0.000263556423000298 0.00251668561310266 1.18436756070465 0.7 30.1 30 1 abnormal cellular respiration 0.000263556423000298 0.00251668561310266 1.18436756070465 0.7 30.1 30 1 small gonad 0.00292250284775358 0.0187364067881109 1.18436756070465 0.7 30.1 30 1 abnormal trachea morphology 0.00292250284775358 0.0187364067881109 1.18436756070465 0.7 30.1 30 1 decreased myocardial infarction size 0.00292250284775358 0.0187364067881109 1.18436756070465 0.7 30.1 30 1 abnormal heart electrocardiography waveform feature 0.00292250284775358 0.0187364067881109 1.18436756070465 0.7 30.1 30 1 decreased muscle cell glucose uptake 0.00292250284775358 0.0187364067881109 1.18436756070465 0.7 30.1 30 1 kidney hemorrhage 0.0364067126798308 0.124397936526207 1.18436756070465 0.7 30.1 30 1 fused cornea and lens 0.0364067126798308 0.124397936526207 1.18436756070465 0.7 30.1 30 1 absent trophoblast giant cells 0.0364067126798308 0.124397936526207 1.18436756070465 0.7 30.1 30 1 decreased incidence of induced tumors 0.0364067126798308 0.124397936526207 1.18436756070465 0.7 30.1 30 1 abnormal neuron specification 0.0364067126798308 0.124397936526207 1.18436756070465 0.7 30.1 30 1 abnormal primordial germ cell migration 0.0364067126798308 0.124397936526207 1.18436756070465 0.7 30.1 30 1 impaired basement membrane formation 0.0364067126798308 0.124397936526207 1.18436756070465 0.7 30.1 30 1 abnormal tibialis anterior morphology 0.0364067126798308 0.124397936526207 1.18436756070465 0.7 30.1 30 1 acrania 0.0364067126798308 0.124397936526207 1.18436756070465 0.7 30.1 30 1 bifid ureter 0.0364067126798308 0.124397936526207 1.18436756070465 0.7 30.1 30 1 abnormal submandibular gland morphology 0.0364067126798308 0.124397936526207 1.18436756070465 0.7 30.1 30 1 increased left ventricle diastolic pressure 0.0364067126798308 0.124397936526207 1.18436756070465 0.7 30.1 30 1 absent pharyngeal arches 0.0364067126798308 0.124397936526207 1.18436756070465 0.7 30.1 30 1 abnormal plasma membrane morphology 0.0364067126798308 0.124397936526207 1.18436756070465 0.7 30.1 30 1 abnormal gonadal fat pad morphology 0.0364067126798308 0.124397936526207 1.18436756070465 0.7 30.1 30 1 increased platelet aggregation 0.0364067126798308 0.124397936526207 1.18436756070465 0.7 30.1 30 1 protruding tongue 0.0364067126798308 0.124397936526207 1.18436756070465 0.7 30.1 30 1 abnormal hippocampus neuron morphology 0.0364067126798308 0.124397936526207 1.18436756070465 0.7 30.1 30 1 increased circulating fructosamine level 0.0364067126798308 0.124397936526207 1.18436756070465 0.7 30.1 30 1 acanthocytosis 0.0364067126798308 0.124397936526207 1.18436756070465 0.7 30.1 30 1 aorta stenosis 0.0364067126798308 0.124397936526207 1.18436756070465 0.7 30.1 30 1 abnormal inferior vena cava valve morphology 0.0364067126798308 0.124397936526207 1.18436756070465 0.7 30.1 30 1 increased compact bone area 0.0364067126798308 0.124397936526207 1.18436756070465 0.7 30.1 30 1 abnormal adaptive thermogenesis 0.0364067126798308 0.124397936526207 1.18436756070465 0.7 30.1 30 1 abnormal circadian temperature homeostasis 0.0364067126798308 0.124397936526207 1.18436756070465 0.7 30.1 30 1 lethality during fetal growth through weaning, complete penetrance 0.0364067126798308 0.124397936526207 1.18436756070465 0.7 30.1 30 1 abnormal fertility/fecundity 1.39687298082043e-08 4.16134316142613e-07 1.18204981596746 0.698630136986301 30.1 30 1 abnormal embryo development 9.33617850674128e-15 7.25742001109967e-13 1.18187939356031 0.698529411764706 30.1 30 1 atrioventricular septal defect 1.3951533035636e-06 2.56121316798115e-05 1.18117519531192 0.69811320754717 30.1 30 1 abnormal blood circulation 1.42323064654075e-05 0.000196682568515006 1.18043278475547 0.697674418604651 30.1 30 1 abnormal skeleton physiology 0.000148676835785962 0.00151602339401519 1.17924042840723 0.696969696969697 30.1 30 1 abnormal QRS complex 0.000148676835785962 0.00151602339401519 1.17924042840723 0.696969696969697 30.1 30 1 increased blood urea nitrogen level 1.82590967170334e-15 1.53964417232612e-13 1.17853323774551 0.696551724137931 30.1 30 1 abnormal nervous system morphology 4.65025467044188e-09 1.52204059114792e-07 1.17794242023066 0.69620253164557 30.1 30 1 abnormal forelimb morphology 8.11644871407341e-06 0.00012236161318944 1.17701124045183 0.695652173913043 30.1 30 1 abnormal allantois morphology 8.11644871407341e-06 0.00012236161318944 1.17701124045183 0.695652173913043 30.1 30 1 abnormal pulmonary artery morphology 0.00161812816217462 0.0116500544237608 1.17701124045183 0.695652173913043 30.1 30 1 perinatal lethality, complete penetrance 8.28806062207294e-22 2.07766859753696e-19 1.17562977185975 0.694835680751174 30.1 30 1 abnormal digit morphology 2.64827436600954e-08 7.16041574505297e-07 1.17496781815938 0.694444444444444 30.1 30 1 increased sarcoma incidence 4.63328337127025e-06 7.38800793976586e-05 1.1740086607568 0.693877551020408 30.1 30 1 abnormal limb morphology 1.52503034180498e-08 4.42416470413269e-07 1.17308786965032 0.693333333333333 30.1 30 1 small kidney 8.93757509731994e-10 3.26896418980771e-08 1.17283151303545 0.693181818181818 30.1 30 1 abnormal pulmonary alveolus morphology 5.28096978118313e-11 2.36692114066541e-09 1.17264114921252 0.693069306930693 30.1 30 1 kinked neural tube 2.64732408372757e-06 4.57306851268913e-05 1.17135253256504 0.692307692307692 30.1 30 1 decreased kidney weight 2.64732408372757e-06 4.57306851268913e-05 1.17135253256504 0.692307692307692 30.1 30 1 abnormal ureter morphology 0.000900865209337751 0.00701377842950753 1.17135253256504 0.692307692307692 30.1 30 1 abnormal Schwann cell morphology 0.000900865209337751 0.00701377842950753 1.17135253256504 0.692307692307692 30.1 30 1 abnormal membranous labyrinth morphology 0.0191970108885016 0.0783471117065591 1.17135253256504 0.692307692307692 30.1 30 1 absent myocardial trabeculae 0.0191970108885016 0.0783471117065591 1.17135253256504 0.692307692307692 30.1 30 1 abnormal digestion 0.0191970108885016 0.0783471117065591 1.17135253256504 0.692307692307692 30.1 30 1 abnormal lung interstitium morphology 0.0191970108885016 0.0783471117065591 1.17135253256504 0.692307692307692 30.1 30 1 anal atresia 0.0191970108885016 0.0783471117065591 1.17135253256504 0.692307692307692 30.1 30 1 absent lateral semicircular canal 0.0191970108885016 0.0783471117065591 1.17135253256504 0.692307692307692 30.1 30 1 abnormal vestibulocochlear ganglion morphology 0.0191970108885016 0.0783471117065591 1.17135253256504 0.692307692307692 30.1 30 1 small otic vesicle 0.0191970108885016 0.0783471117065591 1.17135253256504 0.692307692307692 30.1 30 1 increased circulating ammonia level 0.0191970108885016 0.0783471117065591 1.17135253256504 0.692307692307692 30.1 30 1 absent hypoglossal nerve 0.0191970108885016 0.0783471117065591 1.17135253256504 0.692307692307692 30.1 30 1 increased embryonic tissue cell apoptosis 8.78391461814653e-09 2.73124845157994e-07 1.17135253256504 0.692307692307692 30.1 30 1 increased hepatocyte apoptosis 4.76253192723505e-05 0.000569557604278711 1.17135253256504 0.692307692307692 30.1 30 1 pallor 7.85062593383441e-18 9.15896461477462e-16 1.16986510077765 0.691428571428571 30.1 30 1 ventricular septal defect 3.63483660107926e-14 2.54694536484075e-12 1.16943855783863 0.691176470588235 30.1 30 1 spina bifida 2.70290804340238e-05 0.000350181445727262 1.16825371634132 0.69047619047619 30.1 30 1 abnormal cytotoxic T cell physiology 2.70290804340238e-05 0.000350181445727262 1.16825371634132 0.69047619047619 30.1 30 1 abnormal outer ear morphology 0.000503777422188771 0.00442807893178293 1.16686459182724 0.689655172413793 30.1 30 1 blood in lymph vessels 0.000503777422188771 0.00442807893178293 1.16686459182724 0.689655172413793 30.1 30 1 oxidative stress 9.68704309973226e-10 3.44235995865486e-08 1.1655680756141 0.688888888888889 30.1 30 1 increased osteoclast cell number 4.96154168886215e-07 9.9131204426061e-06 1.16495169905375 0.688524590163934 30.1 30 1 abnormal heart morphology 1.20552952721959e-22 3.74844337369842e-20 1.16459147898602 0.688311688311688 30.1 30 1 embryonic lethality before implantation, complete penetrance 6.58429472366503e-13 4.14643876585234e-11 1.16406411680686 0.688 30.1 30 1 oligodactyly 8.74509546650237e-06 0.000130651201038586 1.16321813997778 0.6875 30.1 30 1 abnormal hair shaft morphology 8.74509546650237e-06 0.000130651201038586 1.16321813997778 0.6875 30.1 30 1 abnormal osteoclast physiology 2.84323953180476e-07 6.0191985832888e-06 1.16321813997778 0.6875 30.1 30 1 abnormal vertebral body morphology 0.000282755889627777 0.0026541708507513 1.16321813997778 0.6875 30.1 30 1 abnormal heart atrium morphology 0.000282755889627777 0.0026541708507513 1.16321813997778 0.6875 30.1 30 1 increased fatty acid level 0.000282755889627777 0.0026541708507513 1.16321813997778 0.6875 30.1 30 1 pancreatic islet hyperplasia 0.000282755889627777 0.0026541708507513 1.16321813997778 0.6875 30.1 30 1 abnormal bone marrow cell number 0.0103156795649306 0.0498741553309325 1.16321813997778 0.6875 30.1 30 1 intraventricular hemorrhage 0.0103156795649306 0.0498741553309325 1.16321813997778 0.6875 30.1 30 1 increased intestinal adenocarcinoma incidence 0.0103156795649306 0.0498741553309325 1.16321813997778 0.6875 30.1 30 1 impaired muscle relaxation 0.0103156795649306 0.0498741553309325 1.16321813997778 0.6875 30.1 30 1 abnormal pulmonary elastic fiber morphology 0.0103156795649306 0.0498741553309325 1.16321813997778 0.6875 30.1 30 1 increased pancreatic beta cell number 0.0103156795649306 0.0498741553309325 1.16321813997778 0.6875 30.1 30 1 dystonia 0.0103156795649306 0.0498741553309325 1.16321813997778 0.6875 30.1 30 1 dilated respiratory conducting tubes 0.0103156795649306 0.0498741553309325 1.16321813997778 0.6875 30.1 30 1 decreased midbrain size 0.0103156795649306 0.0498741553309325 1.16321813997778 0.6875 30.1 30 1 decreased cell proliferation 3.08897945214208e-18 4.15342507416401e-16 1.16150332208101 0.686486486486486 30.1 30 1 impaired hematopoiesis 4.98385723827417e-06 7.87133008267111e-05 1.1611446673575 0.686274509803922 30.1 30 1 abnormal dermal layer morphology 0.000159192089231858 0.00159996089682524 1.16019679415966 0.685714285714286 30.1 30 1 decreased triglyceride level 0.000159192089231858 0.00159996089682524 1.16019679415966 0.685714285714286 30.1 30 1 decreased glycogen level 0.000159192089231858 0.00159996089682524 1.16019679415966 0.685714285714286 30.1 30 1 abnormal hippocampus pyramidal cell morphology 0.000159192089231858 0.00159996089682524 1.16019679415966 0.685714285714286 30.1 30 1 decreased bone volume 0.000159192089231858 0.00159996089682524 1.16019679415966 0.685714285714286 30.1 30 1 embryonic growth arrest 4.19768461902799e-22 1.16019338775913e-19 1.15998569576188 0.685589519650655 30.1 30 1 abnormal muscle physiology 1.81030808570195e-09 6.16868679888165e-08 1.15965363086651 0.685393258426966 30.1 30 1 increased insulin sensitivity 2.45770574840022e-14 1.79810089680751e-12 1.15952068880176 0.685314685314685 30.1 30 1 abnormal chondrocyte morphology 2.84345670252827e-06 4.81163166499256e-05 1.15930158058392 0.685185185185185 30.1 30 1 increased cell proliferation 2.84345670252827e-06 4.81163166499256e-05 1.15930158058392 0.685185185185185 30.1 30 1 abnormal maxilla morphology 2.84345670252827e-06 4.81163166499256e-05 1.15930158058392 0.685185185185185 30.1 30 1 impaired limb coordination 2.84345670252827e-06 4.81163166499256e-05 1.15930158058392 0.685185185185185 30.1 30 1 hemorrhage 1.40461314510377e-22 4.11055905699485e-20 1.15916825090242 0.685106382978723 30.1 30 1 astrocytosis 5.36871215989889e-08 1.3839037821501e-06 1.15887236859555 0.684931506849315 30.1 30 1 decreased brain weight 1.62390296379099e-06 2.94850994337963e-05 1.15765250294439 0.684210526315789 30.1 30 1 abnormal facial morphology 1.62390296379099e-06 2.94850994337963e-05 1.15765250294439 0.684210526315789 30.1 30 1 abnormal frontal bone morphology 8.9860261879801e-05 0.000991252334483393 1.15765250294439 0.684210526315789 30.1 30 1 decreased total retina thickness 8.9860261879801e-05 0.000991252334483393 1.15765250294439 0.684210526315789 30.1 30 1 abnormal triglyceride level 0.00561506403281791 0.0311426349646256 1.15765250294439 0.684210526315789 30.1 30 1 enlarged adrenal glands 0.00561506403281791 0.0311426349646256 1.15765250294439 0.684210526315789 30.1 30 1 shiny skin 0.00561506403281791 0.0311426349646256 1.15765250294439 0.684210526315789 30.1 30 1 decreased tumor incidence 0.00561506403281791 0.0311426349646256 1.15765250294439 0.684210526315789 30.1 30 1 abnormal photoreceptor inner segment morphology 0.00561506403281791 0.0311426349646256 1.15765250294439 0.684210526315789 30.1 30 1 increased left ventricle weight 0.00561506403281791 0.0311426349646256 1.15765250294439 0.684210526315789 30.1 30 1 abnormal blastocyst morphology 0.00561506403281791 0.0311426349646256 1.15765250294439 0.684210526315789 30.1 30 1 absent amnion 0.00561506403281791 0.0311426349646256 1.15765250294439 0.684210526315789 30.1 30 1 decreased eye pigmentation 0.00561506403281791 0.0311426349646256 1.15765250294439 0.684210526315789 30.1 30 1 eyelids fail to open 0.00561506403281791 0.0311426349646256 1.15765250294439 0.684210526315789 30.1 30 1 Leydig cell hypoplasia 0.00561506403281791 0.0311426349646256 1.15765250294439 0.684210526315789 30.1 30 1 increased liver cholesterol level 0.00561506403281791 0.0311426349646256 1.15765250294439 0.684210526315789 30.1 30 1 liver fibrosis 5.08382796367159e-05 0.000599337538371236 1.15548054702893 0.682926829268293 30.1 30 1 hemopericardium 5.08382796367159e-05 0.000599337538371236 1.15548054702893 0.682926829268293 30.1 30 1 lethality at weaning, incomplete penetrance 5.08382796367159e-05 0.000599337538371236 1.15548054702893 0.682926829268293 30.1 30 1 abnormal hair follicle morphology 5.31035767685574e-07 1.0442304127414e-05 1.15482551270521 0.682539682539683 30.1 30 1 gliosis 5.31035767685574e-07 1.0442304127414e-05 1.15482551270521 0.682539682539683 30.1 30 1 omphalocele 2.88178834673065e-05 0.000372386935713896 1.15360476692011 0.681818181818182 30.1 30 1 prolonged PR interval 0.00308515863015232 0.0195773777869997 1.15360476692011 0.681818181818182 30.1 30 1 abnormal basement membrane morphology 0.00308515863015232 0.0195773777869997 1.15360476692011 0.681818181818182 30.1 30 1 abnormal sperm midpiece morphology 0.00308515863015232 0.0195773777869997 1.15360476692011 0.681818181818182 30.1 30 1 failure of palatal shelf elevation 0.00308515863015232 0.0195773777869997 1.15360476692011 0.681818181818182 30.1 30 1 increased circulating creatine kinase level 0.00308515863015232 0.0195773777869997 1.15360476692011 0.681818181818182 30.1 30 1 microcephaly 1.74173638888536e-07 4.08732949750219e-06 1.15249017294241 0.681159420289855 30.1 30 1 decreased spleen weight 1.74173638888536e-07 4.08732949750219e-06 1.15249017294241 0.681159420289855 30.1 30 1 increased respiratory quotient 1.63634785806578e-05 0.000223036454626774 1.15196844810179 0.680851063829787 30.1 30 1 decreased bone trabecula number 1.63634785806578e-05 0.000223036454626774 1.15196844810179 0.680851063829787 30.1 30 1 abnormal kidney morphology 1.09488610596413e-16 1.06805066219049e-14 1.15052848754166 0.68 30.1 30 1 spleen hyperplasia 5.72692527743326e-08 1.46863161109435e-06 1.15052848754166 0.68 30.1 30 1 increased body length 9.30558400784519e-06 0.000135677649248344 1.15052848754166 0.68 30.1 30 1 abnormal egg cylinder morphology 0.00170723668312334 0.0122033081875555 1.15052848754166 0.68 30.1 30 1 abnormal preimplantation embryo development 0.00170723668312334 0.0122033081875555 1.15052848754166 0.68 30.1 30 1 prenatal lethality, complete penetrance 1.29361880665853e-25 4.95057966394322e-23 1.15028504097214 0.679856115107914 30.1 30 1 increased circulating bilirubin level 5.29897985348661e-06 8.34253948452402e-05 1.14925154138457 0.679245283018868 30.1 30 1 abnormal bone structure 4.07488962300204e-18 5.19809637806029e-16 1.14842450371805 0.678756476683938 30.1 30 1 rib bifurcation 0.000950044047246293 0.00730520731847034 1.14811141088716 0.678571428571429 30.1 30 1 abnormal ovulation 0.000950044047246293 0.00730520731847034 1.14811141088716 0.678571428571429 30.1 30 1 premature aging 0.000950044047246293 0.00730520731847034 1.14811141088716 0.678571428571429 30.1 30 1 subcutaneous edema 0.000950044047246293 0.00730520731847034 1.14811141088716 0.678571428571429 30.1 30 1 decreased bone mineral content 2.62330487880412e-19 4.20998121679049e-17 1.14694935480327 0.677884615384615 30.1 30 1 abnormal eyelid morphology 0.000531078162404561 0.00458490664898153 1.14616215552063 0.67741935483871 30.1 30 1 abnormal mitochondrial ATP synthesis coupled electron transport 0.000531078162404561 0.00458490664898153 1.14616215552063 0.67741935483871 30.1 30 1 abnormal heart development 5.7826008132762e-15 4.64007081387889e-13 1.14581671786074 0.677215189873418 30.1 30 1 abnormal lipid homeostasis 1.49616306463381e-12 8.45842187108321e-11 1.14532247628582 0.676923076923077 30.1 30 1 short maxilla 0.000297983244330713 0.00277615475757547 1.14455688639525 0.676470588235294 30.1 30 1 abnormal spleen red pulp morphology 0.000297983244330713 0.00277615475757547 1.14455688639525 0.676470588235294 30.1 30 1 abnormal nervous system development 0.000297983244330713 0.00277615475757547 1.14455688639525 0.676470588235294 30.1 30 1 atelectasis 1.84551903737708e-07 4.25067463469952e-06 1.14385599424192 0.676056338028169 30.1 30 1 corneal opacity 1.84551903737708e-07 4.25067463469952e-06 1.14385599424192 0.676056338028169 30.1 30 1 abnormal liver morphology 1.23845697001086e-16 1.1848698895777e-14 1.14372286388877 0.675977653631285 30.1 30 1 decreased circulating chloride level 0.000167718559806882 0.00167214395799446 1.14321193118209 0.675675675675676 30.1 30 1 preweaning lethality, incomplete penetrance 7.09733001568014e-36 3.53092168280087e-33 1.14175845880015 0.67481662591687 30.1 30 1 abnormal left-right axis patterning 5.35366836547296e-05 0.00062375878497021 1.14108502526362 0.674418604651163 30.1 30 1 failure to gastrulate 3.03416398540103e-05 0.000388045394019798 1.14022963918771 0.673913043478261 30.1 30 1 atrial septal defect 3.03416398540103e-05 0.000388045394019798 1.14022963918771 0.673913043478261 30.1 30 1 cardiac hypertrophy 1.25147552797715e-09 4.35390961656386e-08 1.13947899426395 0.673469387755102 30.1 30 1 abnormal respiratory system physiology 1.72257079129188e-05 0.000234147259198828 1.13947899426395 0.673469387755102 30.1 30 1 anemia 5.40207674948494e-19 8.14403994808714e-17 1.13866075572146 0.672985781990521 30.1 30 1 decreased white adipose tissue amount 5.92416226924399e-07 1.15579244272505e-05 1.13638678532429 0.671641791044776 30.1 30 1 domed cranium 3.38963391957956e-07 7.02642864579513e-06 1.13602602761466 0.671428571428571 30.1 30 1 thick epidermis 3.38963391957956e-07 7.02642864579513e-06 1.13602602761466 0.671428571428571 30.1 30 1 cardiac fibrosis 2.0988944799753e-08 5.96685716450121e-07 1.1346042178179 0.670588235294118 30.1 30 1 small spleen 6.92286922498086e-09 2.20777399963332e-07 1.13416673788043 0.67032967032967 30.1 30 1 increased bone mineral content 2.50578826633948e-10 1.02182759221631e-08 1.13314327564141 0.669724770642202 30.1 30 1 abnormal skeleton morphology 8.30751027327629e-11 3.59870330331286e-09 1.13287331893488 0.669565217391304 30.1 30 1 increased tumor incidence 1.58836789038709e-11 7.59820216795748e-10 1.13251736795491 0.669354838709677 30.1 30 1 decreased hemoglobin content 1.05817706411589e-12 6.34268782406812e-11 1.127969105433 0.666666666666667 30.1 30 1 epidermal hyperplasia 3.316129260559e-06 5.4809777645452e-05 1.127969105433 0.666666666666667 30.1 30 1 muscular ventricular septal defect 3.316129260559e-06 5.4809777645452e-05 1.127969105433 0.666666666666667 30.1 30 1 absent vitelline blood vessels 5.81536481977648e-06 9.06941692112477e-05 1.127969105433 0.666666666666667 30.1 30 1 abnormal mandible morphology 1.02100261554032e-05 0.000145962299204399 1.127969105433 0.666666666666667 30.1 30 1 neurodegeneration 1.02100261554032e-05 0.000145962299204399 1.127969105433 0.666666666666667 30.1 30 1 abnormal long bone epiphyseal plate proliferative zone 1.02100261554032e-05 0.000145962299204399 1.127969105433 0.666666666666667 30.1 30 1 thymus atrophy 3.16002448089685e-05 0.000402074726149919 1.127969105433 0.666666666666667 30.1 30 1 abnormal osteoclast morphology 3.16002448089685e-05 0.000402074726149919 1.127969105433 0.666666666666667 30.1 30 1 disheveled coat 9.84566780420996e-05 0.00107890302480054 1.127969105433 0.666666666666667 30.1 30 1 abnormal retinal blood vessel morphology 0.000309449517649135 0.00286154526078894 1.127969105433 0.666666666666667 30.1 30 1 abnormal aorta morphology 0.000550913997311412 0.00469314578189088 1.127969105433 0.666666666666667 30.1 30 1 decreased brown adipose tissue amount 0.000550913997311412 0.00469314578189088 1.127969105433 0.666666666666667 30.1 30 1 increased osteoblast cell number 0.000550913997311412 0.00469314578189088 1.127969105433 0.666666666666667 30.1 30 1 abnormal heart tube morphology 0.000984219420565715 0.00745280307049381 1.127969105433 0.666666666666667 30.1 30 1 emphysema 0.000984219420565715 0.00745280307049381 1.127969105433 0.666666666666667 30.1 30 1 abnormal spleen marginal zone morphology 0.000984219420565715 0.00745280307049381 1.127969105433 0.666666666666667 30.1 30 1 abnormal trigeminal nerve morphology 0.00176572387008268 0.0124602500051934 1.127969105433 0.666666666666667 30.1 30 1 thick interventricular septum 0.00176572387008268 0.0124602500051934 1.127969105433 0.666666666666667 30.1 30 1 abnormal digestive system morphology 0.00318410994556601 0.0200264816424664 1.127969105433 0.666666666666667 30.1 30 1 abnormal body weight 0.00318410994556601 0.0200264816424664 1.127969105433 0.666666666666667 30.1 30 1 increased hemangiosarcoma incidence 0.00318410994556601 0.0200264816424664 1.127969105433 0.666666666666667 30.1 30 1 abnormal inner cell mass apoptosis 0.00318410994556601 0.0200264816424664 1.127969105433 0.666666666666667 30.1 30 1 abnormal scapula morphology 0.00577902654144122 0.03176868181621 1.127969105433 0.666666666666667 30.1 30 1 liver degeneration 0.00577902654144122 0.03176868181621 1.127969105433 0.666666666666667 30.1 30 1 left pulmonary isomerism 0.00577902654144122 0.03176868181621 1.127969105433 0.666666666666667 30.1 30 1 abnormal embryonic/fetal subventricular zone morphology 0.00577902654144122 0.03176868181621 1.127969105433 0.666666666666667 30.1 30 1 abnormal megakaryocyte differentiation 0.0105763396096537 0.050111704340978 1.127969105433 0.666666666666667 30.1 30 1 thick dermal layer 0.0105763396096537 0.050111704340978 1.127969105433 0.666666666666667 30.1 30 1 acidosis 0.0105763396096537 0.050111704340978 1.127969105433 0.666666666666667 30.1 30 1 abnormal body wall morphology 0.0105763396096537 0.050111704340978 1.127969105433 0.666666666666667 30.1 30 1 increased circulating glycerol level 0.0105763396096537 0.050111704340978 1.127969105433 0.666666666666667 30.1 30 1 absent inner cell mass 0.0105763396096537 0.050111704340978 1.127969105433 0.666666666666667 30.1 30 1 darkened coat color 0.0105763396096537 0.050111704340978 1.127969105433 0.666666666666667 30.1 30 1 decreased tumor latency 0.0105763396096537 0.050111704340978 1.127969105433 0.666666666666667 30.1 30 1 increased effector memory CD8-positive, alpha-beta T cell number 0.0105763396096537 0.050111704340978 1.127969105433 0.666666666666667 30.1 30 1 abnormal metanephric mesenchyme morphology 0.0105763396096537 0.050111704340978 1.127969105433 0.666666666666667 30.1 30 1 abnormal hypoglossal nerve topology 0.0105763396096537 0.050111704340978 1.127969105433 0.666666666666667 30.1 30 1 absent incisors 0.0195729845344001 0.078528708111807 1.127969105433 0.666666666666667 30.1 30 1 abnormal enteric neuron morphology 0.0195729845344001 0.078528708111807 1.127969105433 0.666666666666667 30.1 30 1 abnormal apical ectodermal ridge morphology 0.0195729845344001 0.078528708111807 1.127969105433 0.666666666666667 30.1 30 1 increased airway responsiveness 0.0195729845344001 0.078528708111807 1.127969105433 0.666666666666667 30.1 30 1 abnormal respiratory system morphology 0.0195729845344001 0.078528708111807 1.127969105433 0.666666666666667 30.1 30 1 abnormal trophectoderm morphology 0.0195729845344001 0.078528708111807 1.127969105433 0.666666666666667 30.1 30 1 abnormal energy homeostasis 0.0195729845344001 0.078528708111807 1.127969105433 0.666666666666667 30.1 30 1 abnormal cerebral aqueduct morphology 0.0195729845344001 0.078528708111807 1.127969105433 0.666666666666667 30.1 30 1 absent chorion 0.0195729845344001 0.078528708111807 1.127969105433 0.666666666666667 30.1 30 1 bicuspid aortic valve 0.0195729845344001 0.078528708111807 1.127969105433 0.666666666666667 30.1 30 1 decreased trabecular bone mass 0.0195729845344001 0.078528708111807 1.127969105433 0.666666666666667 30.1 30 1 herniated liver 0.0195729845344001 0.078528708111807 1.127969105433 0.666666666666667 30.1 30 1 decreased brown adipose tissue mass 0.0195729845344001 0.078528708111807 1.127969105433 0.666666666666667 30.1 30 1 mesocardia 0.0367964500879839 0.124957228114485 1.127969105433 0.666666666666667 30.1 30 1 abnormal glossopharyngeal nerve morphology 0.0367964500879839 0.124957228114485 1.127969105433 0.666666666666667 30.1 30 1 abnormal tracheal ciliated epithelium morphology 0.0367964500879839 0.124957228114485 1.127969105433 0.666666666666667 30.1 30 1 abnormal corticospinal tract morphology 0.0367964500879839 0.124957228114485 1.127969105433 0.666666666666667 30.1 30 1 abnormal defecation 0.0367964500879839 0.124957228114485 1.127969105433 0.666666666666667 30.1 30 1 decreased renal glomerular filtration rate 0.0367964500879839 0.124957228114485 1.127969105433 0.666666666666667 30.1 30 1 increased skeletal muscle glycogen level 0.0367964500879839 0.124957228114485 1.127969105433 0.666666666666667 30.1 30 1 abnormal vitelline vein connection 0.0367964500879839 0.124957228114485 1.127969105433 0.666666666666667 30.1 30 1 crypts of Lieberkuhn abscesses 0.0708491807218909 0.197671576717944 1.127969105433 0.666666666666667 30.1 30 1 abnormal sympathetic neuron morphology 0.0708491807218909 0.197671576717944 1.127969105433 0.666666666666667 30.1 30 1 increased pheochromocytoma incidence 0.0708491807218909 0.197671576717944 1.127969105433 0.666666666666667 30.1 30 1 long gestation period 0.0708491807218909 0.197671576717944 1.127969105433 0.666666666666667 30.1 30 1 polycythemia 0.0708491807218909 0.197671576717944 1.127969105433 0.666666666666667 30.1 30 1 abnormal NMDA-mediated synaptic currents 0.0708491807218909 0.197671576717944 1.127969105433 0.666666666666667 30.1 30 1 decreased circulating bicarbonate level 0.0708491807218909 0.197671576717944 1.127969105433 0.666666666666667 30.1 30 1 genetic imprinting 0.0708491807218909 0.197671576717944 1.127969105433 0.666666666666667 30.1 30 1 premature neuronal precursor differentiation 0.0708491807218909 0.197671576717944 1.127969105433 0.666666666666667 30.1 30 1 abnormal ovary physiology 0.0708491807218909 0.197671576717944 1.127969105433 0.666666666666667 30.1 30 1 abnormal thymus physiology 0.0708491807218909 0.197671576717944 1.127969105433 0.666666666666667 30.1 30 1 decreased cellular sensitivity to ionizing radiation 0.0708491807218909 0.197671576717944 1.127969105433 0.666666666666667 30.1 30 1 abnormal gallbladder physiology 0.0708491807218909 0.197671576717944 1.127969105433 0.666666666666667 30.1 30 1 absent adrenal gland 0.0708491807218909 0.197671576717944 1.127969105433 0.666666666666667 30.1 30 1 abnormal inguinal fat pad morphology 0.0708491807218909 0.197671576717944 1.127969105433 0.666666666666667 30.1 30 1 positive geotaxis 0.0708491807218909 0.197671576717944 1.127969105433 0.666666666666667 30.1 30 1 abnormal cerebellar layer morphology 0.0708491807218909 0.197671576717944 1.127969105433 0.666666666666667 30.1 30 1 abnormal incisor color 0.0708491807218909 0.197671576717944 1.127969105433 0.666666666666667 30.1 30 1 abnormal telomere morphology 0.0708491807218909 0.197671576717944 1.127969105433 0.666666666666667 30.1 30 1 abnormal ventricle myocardium morphology 0.0708491807218909 0.197671576717944 1.127969105433 0.666666666666667 30.1 30 1 prolonged RR interval 0.0708491807218909 0.197671576717944 1.127969105433 0.666666666666667 30.1 30 1 shortened ST segment 0.0708491807218909 0.197671576717944 1.127969105433 0.666666666666667 30.1 30 1 iris coloboma 0.0708491807218909 0.197671576717944 1.127969105433 0.666666666666667 30.1 30 1 abnormal oxidative phosphorylation 0.0708491807218909 0.197671576717944 1.127969105433 0.666666666666667 30.1 30 1 abnormal ductus venosus valve topology 0.0708491807218909 0.197671576717944 1.127969105433 0.666666666666667 30.1 30 1 increased cardiac muscle glycogen level 0.0708491807218909 0.197671576717944 1.127969105433 0.666666666666667 30.1 30 1 thin ventricular wall 1.2596929399035e-08 3.82059093522354e-07 1.127969105433 0.666666666666667 30.1 30 1 abnormal dendritic spine morphology 1.79490375469875e-05 0.000241995831426187 1.127969105433 0.666666666666667 30.1 30 1 abnormal intestine morphology 3.67220751863377e-07 7.56134213944806e-06 1.12034769255845 0.662162162162162 30.1 30 1 thrombocytopenia 1.14690112100013e-12 6.71274479644195e-11 1.12019000815415 0.662068965517241 30.1 30 1 increased circulating free fatty acid level 6.41352556389283e-07 1.24152878133723e-05 1.12002566102854 0.661971830985915 30.1 30 1 enlarged liver 4.48014174256273e-09 1.4852899511157e-07 1.11668941437867 0.66 30.1 30 1 thymus hypoplasia 6.18952856567734e-12 3.20085453147285e-10 1.11570857167829 0.659420289855073 30.1 30 1 osteoporosis 0.00010132636401708 0.00110306052731941 1.11515127468944 0.659090909090909 30.1 30 1 muscular atrophy 0.00010132636401708 0.00110306052731941 1.11515127468944 0.659090909090909 30.1 30 1 hunched posture 2.17116414683629e-07 4.86555929302277e-06 1.11369101549081 0.658227848101266 30.1 30 1 decreased hair follicle number 0.000317446055820498 0.00291382680388741 1.1131274066773 0.657894736842105 30.1 30 1 incomplete somite formation 0.000317446055820498 0.00291382680388741 1.1131274066773 0.657894736842105 30.1 30 1 decreased hematocrit 2.12695980879153e-12 1.17573611652643e-10 1.11251747385173 0.657534246575342 30.1 30 1 seminiferous tubule degeneration 6.6093282630906e-07 1.27022819585125e-05 1.11251747385173 0.657534246575342 30.1 30 1 short snout 1.53040856973021e-09 5.28734905167208e-08 1.11230286785754 0.657407407407407 30.1 30 1 internal hemorrhage 2.01734055930358e-06 3.61016880666738e-05 1.11113374565042 0.656716417910448 30.1 30 1 decreased caudal vertebrae number 3.52854451840272e-06 5.73676764021357e-05 1.11034458816061 0.65625 30.1 30 1 abnormal depression-related behavior 0.00100514795588751 0.00758275508764309 1.11034458816061 0.65625 30.1 30 1 abnormal embryonic hematopoiesis 0.00100514795588751 0.00758275508764309 1.11034458816061 0.65625 30.1 30 1 short limbs 7.34796703555701e-08 1.85564142141605e-06 1.10852136223588 0.655172413793103 30.1 30 1 lordosis 0.00179795063485559 0.0125985437964723 1.10852136223588 0.655172413793103 30.1 30 1 short sternum 0.00179795063485559 0.0125985437964723 1.10852136223588 0.655172413793103 30.1 30 1 perinatal lethality, incomplete penetrance 4.54838642770281e-18 5.65705561945537e-16 1.10800505046958 0.654867256637168 30.1 30 1 increased heart weight 1.13879516628527e-11 5.66550595226923e-10 1.10768189130651 0.654676258992806 30.1 30 1 abnormal platelet physiology 1.89893313042941e-05 0.000254641302530628 1.10746057624331 0.654545454545455 30.1 30 1 abnormal skeleton development 2.22856178270717e-07 4.90579418980893e-06 1.10708078866572 0.654320987654321 30.1 30 1 decreased heart weight 2.22856178270717e-07 4.90579418980893e-06 1.10708078866572 0.654320987654321 30.1 30 1 increased neuron apoptosis 2.22856178270717e-07 4.90579418980893e-06 1.10708078866572 0.654320987654321 30.1 30 1 distended pericardium 3.33523047513207e-05 0.000420605560285173 1.10627739186698 0.653846153846154 30.1 30 1 ventricular hypoplasia 0.00323038280027392 0.0200396348041041 1.10627739186698 0.653846153846154 30.1 30 1 increased leukemia incidence 0.00323038280027392 0.0200396348041041 1.10627739186698 0.653846153846154 30.1 30 1 pulmonary edema 0.00323038280027392 0.0200396348041041 1.10627739186698 0.653846153846154 30.1 30 1 absent kidney 5.86581966132976e-05 0.00067866169337478 1.1049493277711 0.653061224489796 30.1 30 1 increased inflammatory response 2.4868405391136e-08 6.95057959667988e-07 1.10422238742388 0.652631578947368 30.1 30 1 hydroencephaly 9.28631137203568e-10 3.34778254173025e-08 1.10344803792359 0.652173913043478 30.1 30 1 abnormal sternum morphology 2.06301318672189e-06 3.67867046736251e-05 1.10344803792359 0.652173913043478 30.1 30 1 abnormal inner ear morphology 0.000103321856685947 0.00111988286930847 1.10344803792359 0.652173913043478 30.1 30 1 abnormal lymphocyte physiology 0.000103321856685947 0.00111988286930847 1.10344803792359 0.652173913043478 30.1 30 1 abnormal hepatocyte physiology 0.00583584075761052 0.0319750085562911 1.10344803792359 0.652173913043478 30.1 30 1 abnormal vasculogenesis 0.000182307334231858 0.0017900730559664 1.10173726577177 0.651162790697674 30.1 30 1 increased circulating aspartate transaminase level 6.30206551914547e-06 9.76721992453232e-05 1.10111269816079 0.650793650793651 30.1 30 1 decreased bone mineral density 2.14278110454971e-20 4.44180666463951e-18 1.10040595060099 0.650375939849624 30.1 30 1 increased erythrocyte cell number 1.10283640050391e-05 0.000155869633309857 1.09976987779717 0.65 30.1 30 1 anencephaly 0.0106155348050802 0.0501541174314094 1.09976987779717 0.65 30.1 30 1 abnormal postnatal subventricular zone morphology 0.0106155348050802 0.0501541174314094 1.09976987779717 0.65 30.1 30 1 abnormal sperm mitochondrial sheath morphology 0.0106155348050802 0.0501541174314094 1.09976987779717 0.65 30.1 30 1 decreased leukocyte cell number 3.57911815291975e-11 1.66412269259587e-09 1.09915237646208 0.64963503649635 30.1 30 1 abnormal myocardial fiber morphology 2.53778350060591e-08 7.01415161973023e-07 1.09889773673627 0.649484536082474 30.1 30 1 enlarged spleen 8.3524365730129e-22 2.07766859753696e-19 1.09859490997902 0.649305555555556 30.1 30 1 decreased birth body size 1.64384584990136e-09 5.64009179535123e-08 1.09828570792161 0.649122807017544 30.1 30 1 respiratory failure 4.06874082385187e-12 2.15340272326203e-10 1.09808912913014 0.649006622516556 30.1 30 1 cleft palate 1.07295305032716e-10 4.60167364256693e-09 1.09783252628021 0.648854961832061 30.1 30 1 abnormal chromosome morphology 0.000571106670588678 0.00478325873094053 1.09748345393481 0.648648648648649 30.1 30 1 increased trabecular bone volume 0.000571106670588678 0.00478325873094053 1.09748345393481 0.648648648648649 30.1 30 1 reduced fertility 3.64613247556771e-11 1.67958417277309e-09 1.09550956283061 0.647482014388489 30.1 30 1 microphthalmia 4.14323305151907e-12 2.1697457296113e-10 1.0947935435085 0.647058823529412 30.1 30 1 abnormal endoderm development 0.00101462037777603 0.00762497942512951 1.0947935435085 0.647058823529412 30.1 30 1 abnormal urinary bladder morphology 0.0194830724457108 0.078528708111807 1.0947935435085 0.647058823529412 30.1 30 1 abnormal testis development 0.0194830724457108 0.078528708111807 1.0947935435085 0.647058823529412 30.1 30 1 abnormal ectoplacental cone morphology 0.0194830724457108 0.078528708111807 1.0947935435085 0.647058823529412 30.1 30 1 coloboma 0.0194830724457108 0.078528708111807 1.0947935435085 0.647058823529412 30.1 30 1 decreased body fat mass 0.0194830724457108 0.078528708111807 1.0947935435085 0.647058823529412 30.1 30 1 abnormal cell cytoskeleton morphology 0.0194830724457108 0.078528708111807 1.0947935435085 0.647058823529412 30.1 30 1 increased lung adenocarcinoma incidence 5.94602850616961e-05 0.000686345517823523 1.0947935435085 0.647058823529412 30.1 30 1 kyphosis 7.16442964657447e-12 3.63704464201102e-10 1.09413003227001 0.646666666666667 30.1 30 1 abnormal neuron morphology 2.57977119248107e-08 7.09080755944382e-07 1.09378822345018 0.646464646464647 30.1 30 1 abnormal brain morphology 1.409140173662e-12 8.15171205112609e-11 1.09293900899098 0.645962732919255 30.1 30 1 abnormal cardiovascular system morphology 0.000104515301313896 0.00112790373977577 1.09272007088822 0.645833333333333 30.1 30 1 curly tail 0.000104515301313896 0.00112790373977577 1.09272007088822 0.645833333333333 30.1 30 1 hypoglycemia 7.771086933506e-08 1.9525837118279e-06 1.09158300525774 0.645161290322581 30.1 30 1 pericardial effusion 1.11674342159361e-05 0.000157388060125445 1.09158300525774 0.645161290322581 30.1 30 1 osteopetrosis 0.00180811261722236 0.0125985437964723 1.09158300525774 0.645161290322581 30.1 30 1 abnormal capillary morphology 0.00180811261722236 0.0125985437964723 1.09158300525774 0.645161290322581 30.1 30 1 decreased thymus weight 0.00180811261722236 0.0125985437964723 1.09158300525774 0.645161290322581 30.1 30 1 abnormal podocyte morphology 0.00180811261722236 0.0125985437964723 1.09158300525774 0.645161290322581 30.1 30 1 small cranium 0.00180811261722236 0.0125985437964723 1.09158300525774 0.645161290322581 30.1 30 1 irregular heartbeat 0.000183976909429467 0.00179097567634566 1.0903701352519 0.644444444444444 30.1 30 1 cardiomyopathy 0.000183976909429467 0.00179097567634566 1.0903701352519 0.644444444444444 30.1 30 1 abnormal glucose homeostasis 9.55608968473184e-14 6.51254057281382e-12 1.08768449452468 0.642857142857143 30.1 30 1 hydronephrosis 4.07061319306638e-07 8.2322360306932e-06 1.08768449452468 0.642857142857143 30.1 30 1 short mandible 3.41749059703239e-05 0.000426520081670927 1.08768449452468 0.642857142857143 30.1 30 1 abnormal seminal vesicle morphology 3.41749059703239e-05 0.000426520081670927 1.08768449452468 0.642857142857143 30.1 30 1 straub tail 0.00323394755118818 0.0200396348041041 1.08768449452468 0.642857142857143 30.1 30 1 increased triglyceride level 0.00323394755118818 0.0200396348041041 1.08768449452468 0.642857142857143 30.1 30 1 midline facial cleft 0.0361909974097934 0.124397936526207 1.08768449452468 0.642857142857143 30.1 30 1 translucent skin 0.0361909974097934 0.124397936526207 1.08768449452468 0.642857142857143 30.1 30 1 increased aggression towards males 0.0361909974097934 0.124397936526207 1.08768449452468 0.642857142857143 30.1 30 1 intestinal obstruction 0.0361909974097934 0.124397936526207 1.08768449452468 0.642857142857143 30.1 30 1 amyloid beta deposits 0.0361909974097934 0.124397936526207 1.08768449452468 0.642857142857143 30.1 30 1 abnormal ventral body wall morphology 0.0361909974097934 0.124397936526207 1.08768449452468 0.642857142857143 30.1 30 1 abnormal sagittal suture morphology 0.0361909974097934 0.124397936526207 1.08768449452468 0.642857142857143 30.1 30 1 abnormal decidualization 0.0361909974097934 0.124397936526207 1.08768449452468 0.642857142857143 30.1 30 1 split sternum 0.0361909974097934 0.124397936526207 1.08768449452468 0.642857142857143 30.1 30 1 spina bifida occulta 0.0361909974097934 0.124397936526207 1.08768449452468 0.642857142857143 30.1 30 1 testis degeneration 0.0361909974097934 0.124397936526207 1.08768449452468 0.642857142857143 30.1 30 1 decreased body length 7.18351037289205e-20 1.23234358983234e-17 1.08680234976026 0.642335766423358 30.1 30 1 enlarged heart 4.83046034626275e-17 5.22424787449069e-15 1.08664265113912 0.642241379310345 30.1 30 1 abnormal heart ventricle morphology 1.22959286523057e-06 2.27406115409744e-05 1.08458567830096 0.641025641025641 30.1 30 1 decreased trabecular bone volume 0.000573010178545136 0.00479113552649084 1.08458567830096 0.641025641025641 30.1 30 1 abnormal tooth morphology 1.12461681726435e-05 0.000158049962313281 1.08390781225202 0.640625 30.1 30 1 decreased rib number 2.36312473104501e-07 5.13715681729965e-06 1.08361076982608 0.640449438202247 30.1 30 1 increased circulating chloride level 0.000104983762002999 0.00112806526126332 1.08285034121568 0.64 30.1 30 1 abnormal keratinocyte physiology 0.00580966241213074 0.0318666708934404 1.08285034121568 0.64 30.1 30 1 increased cellular sensitivity to ionizing radiation 0.00580966241213074 0.0318666708934404 1.08285034121568 0.64 30.1 30 1 postnatal growth retardation 1.16187621962911e-41 7.22541774081853e-39 1.08097039270662 0.638888888888889 30.1 30 1 abnormal uterus morphology 0.00101435750706127 0.00762497942512951 1.08097039270662 0.638888888888889 30.1 30 1 hepatic necrosis 0.000184317496741503 0.00179097567634566 1.07997042009543 0.638297872340426 30.1 30 1 abnormal amino acid level 0.000324024032107715 0.00296327124951449 1.07669778245877 0.636363636363636 30.1 30 1 decreased blood urea nitrogen level 0.000324024032107715 0.00296327124951449 1.07669778245877 0.636363636363636 30.1 30 1 abnormal abdominal fat pad morphology 0.0104932953861968 0.050111704340978 1.07669778245877 0.636363636363636 30.1 30 1 increased body size 0.0104932953861968 0.050111704340978 1.07669778245877 0.636363636363636 30.1 30 1 abnormal tracheal cartilage morphology 0.0104932953861968 0.050111704340978 1.07669778245877 0.636363636363636 30.1 30 1 abnormal cochlear sensory epithelium morphology 0.0104932953861968 0.050111704340978 1.07669778245877 0.636363636363636 30.1 30 1 decreased cardiac output 0.0104932953861968 0.050111704340978 1.07669778245877 0.636363636363636 30.1 30 1 parakeratosis 0.0104932953861968 0.050111704340978 1.07669778245877 0.636363636363636 30.1 30 1 abnormal mesenteric lymph node morphology 0.0104932953861968 0.050111704340978 1.07669778245877 0.636363636363636 30.1 30 1 rough coat 0.0104932953861968 0.050111704340978 1.07669778245877 0.636363636363636 30.1 30 1 increased mammary gland tumor incidence 0.0104932953861968 0.050111704340978 1.07669778245877 0.636363636363636 30.1 30 1 increased bone volume 0.0104932953861968 0.050111704340978 1.07669778245877 0.636363636363636 30.1 30 1 abnormal awl hair morphology 0.0683874085176697 0.197671576717944 1.07669778245877 0.636363636363636 30.1 30 1 abnormal sebaceous gland morphology 0.0683874085176697 0.197671576717944 1.07669778245877 0.636363636363636 30.1 30 1 abnormal enteric ganglia morphology 0.0683874085176697 0.197671576717944 1.07669778245877 0.636363636363636 30.1 30 1 abnormal hypothalamus secretion 0.0683874085176697 0.197671576717944 1.07669778245877 0.636363636363636 30.1 30 1 vasculitis 0.0683874085176697 0.197671576717944 1.07669778245877 0.636363636363636 30.1 30 1 abnormal primary sex determination 0.0683874085176697 0.197671576717944 1.07669778245877 0.636363636363636 30.1 30 1 patent ductus arteriosus 0.0683874085176697 0.197671576717944 1.07669778245877 0.636363636363636 30.1 30 1 allodynia 0.0683874085176697 0.197671576717944 1.07669778245877 0.636363636363636 30.1 30 1 fused joints 0.0683874085176697 0.197671576717944 1.07669778245877 0.636363636363636 30.1 30 1 pulmonary hypertension 0.0683874085176697 0.197671576717944 1.07669778245877 0.636363636363636 30.1 30 1 abnormal ureter development 0.0683874085176697 0.197671576717944 1.07669778245877 0.636363636363636 30.1 30 1 pathological neovascularization 0.0683874085176697 0.197671576717944 1.07669778245877 0.636363636363636 30.1 30 1 increased glycogen level 0.0683874085176697 0.197671576717944 1.07669778245877 0.636363636363636 30.1 30 1 abnormal palate development 0.0683874085176697 0.197671576717944 1.07669778245877 0.636363636363636 30.1 30 1 abnormal aorta smooth muscle morphology 0.0683874085176697 0.197671576717944 1.07669778245877 0.636363636363636 30.1 30 1 abnormal extraembryonic ectoderm morphology 0.0683874085176697 0.197671576717944 1.07669778245877 0.636363636363636 30.1 30 1 decreased core body temperature 0.0683874085176697 0.197671576717944 1.07669778245877 0.636363636363636 30.1 30 1 increased granulocyte number 3.72397384867274e-06 6.0151850315412e-05 1.07461921531117 0.635135135135135 30.1 30 1 prenatal lethality, incomplete penetrance 8.6643001599303e-21 1.95443949873772e-18 1.0741679474436 0.634868421052632 30.1 30 1 increased susceptibility to injury 0.000104805724548138 0.00112806526126332 1.07373982151795 0.634615384615385 30.1 30 1 abnormal definitive hematopoiesis 2.37780965908617e-07 5.14330567563203e-06 1.07338995517011 0.634408602150538 30.1 30 1 sparse hair 1.23573746348345e-06 2.27696069660376e-05 1.07294622224115 0.634146341463415 30.1 30 1 abnormal mammary gland development 0.000570455104386724 0.00478325873094053 1.07294622224115 0.634146341463415 30.1 30 1 Leydig cell hyperplasia 0.000570455104386724 0.00478325873094053 1.07294622224115 0.634146341463415 30.1 30 1 decreased liver weight 6.46914261401605e-06 9.96408189000924e-05 1.0723649946018 0.633802816901408 30.1 30 1 ataxia 3.36615581022629e-14 2.42262291819511e-12 1.07212905070859 0.633663366336634 30.1 30 1 abnormal eating behavior 3.4207339213407e-05 0.000426520081670927 1.07157065016135 0.633333333333333 30.1 30 1 abnormal hair cycle 0.003203486368629 0.0200396348041041 1.07157065016135 0.633333333333333 30.1 30 1 enhanced paired-pulse facilitation 0.003203486368629 0.0200396348041041 1.07157065016135 0.633333333333333 30.1 30 1 abnormal brain vasculature morphology 0.003203486368629 0.0200396348041041 1.07157065016135 0.633333333333333 30.1 30 1 abnormal renal glomerulus morphology 2.66319275203415e-08 7.16182915749725e-07 1.07105323314051 0.63302752293578 30.1 30 1 abnormal visceral yolk sac morphology 2.14207003713461e-06 3.79245495898388e-05 1.07085674566424 0.632911392405063 30.1 30 1 abnormal long bone hypertrophic chondrocyte zone 0.000183491426076038 0.00179097567634566 1.07041966127826 0.63265306122449 30.1 30 1 decreased circulating creatinine level 0.000183491426076038 0.00179097567634566 1.07041966127826 0.63265306122449 30.1 30 1 postnatal lethality 7.61280465884236e-12 3.82562658361017e-10 1.07021165123914 0.632530120481928 30.1 30 1 limb grasping 8.69683467867197e-13 5.27643323492598e-11 1.06909159718238 0.631868131868132 30.1 30 1 abnormal circulating amino acid level 5.96450143546998e-05 0.000686884135219054 1.06860231041021 0.631578947368421 30.1 30 1 decreased threshold for auditory brainstem response 0.0010059534387627 0.00758275508764309 1.06860231041021 0.631578947368421 30.1 30 1 kyphoscoliosis 0.0190813834556578 0.0783471117065591 1.06860231041021 0.631578947368421 30.1 30 1 thin dermal layer 0.0190813834556578 0.0783471117065591 1.06860231041021 0.631578947368421 30.1 30 1 short vibrissae 0.0190813834556578 0.0783471117065591 1.06860231041021 0.631578947368421 30.1 30 1 abnormal stationary movement 0.0190813834556578 0.0783471117065591 1.06860231041021 0.631578947368421 30.1 30 1 increased malignant tumor incidence 0.0190813834556578 0.0783471117065591 1.06860231041021 0.631578947368421 30.1 30 1 abnormal nasal septum morphology 0.0190813834556578 0.0783471117065591 1.06860231041021 0.631578947368421 30.1 30 1 abnormal neural crest cell migration 0.0190813834556578 0.0783471117065591 1.06860231041021 0.631578947368421 30.1 30 1 decreased fertilization frequency 0.0190813834556578 0.0783471117065591 1.06860231041021 0.631578947368421 30.1 30 1 thin interventricular septum 0.0190813834556578 0.0783471117065591 1.06860231041021 0.631578947368421 30.1 30 1 decreased body weight 4.04344051415449e-79 2.01161165579186e-75 1.06737948870336 0.630856219709208 30.1 30 1 cyanosis 2.93519699381197e-13 1.89644221353435e-11 1.06628329497963 0.630208333333333 30.1 30 1 decreased bone marrow cell number 6.43935902186297e-06 9.94900966887214e-05 1.0661625791079 0.63013698630137 30.1 30 1 abnormal heart valve morphology 0.005720302981599 0.0315854687385739 1.06530415513117 0.62962962962963 30.1 30 1 abnormal eye muscle morphology 0.005720302981599 0.0315854687385739 1.06530415513117 0.62962962962963 30.1 30 1 abnormal palate morphology 0.005720302981599 0.0315854687385739 1.06530415513117 0.62962962962963 30.1 30 1 reduced female fertility 1.29950038432919e-15 1.11465765724788e-13 1.06476394004236 0.629310344827586 30.1 30 1 increased circulating HDL cholesterol level 7.89473477055101e-08 1.97368369263775e-06 1.06351372797969 0.628571428571429 30.1 30 1 ovary cysts 0.00177720934411923 0.0125058224709946 1.06351372797969 0.628571428571429 30.1 30 1 increased red blood cell distribution width 0.00177720934411923 0.0125058224709946 1.06351372797969 0.628571428571429 30.1 30 1 decreased circulating cholesterol level 1.48543948505897e-12 8.45842187108321e-11 1.06324956659668 0.628415300546448 30.1 30 1 increased spleen weight 2.64396343958698e-08 7.16041574505297e-07 1.0630859268019 0.628318584070796 30.1 30 1 increased circulating alanine transaminase level 3.68985753186518e-06 5.97949225440692e-05 1.06289396473494 0.628205128205128 30.1 30 1 cataract 8.87012894126799e-09 2.74092493682039e-07 1.06271469437489 0.628099173553719 30.1 30 1 abnormal organ of Corti morphology 0.000564136633693647 0.00475691483495914 1.06238950627992 0.627906976744186 30.1 30 1 decreased oxygen consumption 0.000564136633693647 0.00475691483495914 1.06238950627992 0.627906976744186 30.1 30 1 kinked tail 1.36057833300618e-07 3.25426788783929e-06 1.061617981584 0.627450980392157 30.1 30 1 impaired balance 1.36057833300618e-07 3.25426788783929e-06 1.061617981584 0.627450980392157 30.1 30 1 increased kidney weight 0.000181654881062034 0.00178957036293786 1.061617981584 0.627450980392157 30.1 30 1 decreased circulating glucose level 3.32157699100345e-18 4.34864356059004e-16 1.06126125511169 0.627240143369176 30.1 30 1 rib fusion 1.93692461126834e-05 0.000258343161958712 1.06062766630267 0.626865671641791 30.1 30 1 postnatal lethality, incomplete penetrance 1.77608467860895e-35 8.03274661461777e-33 1.06044982799511 0.626760563380282 30.1 30 1 abnormal startle reflex 0.010255392111018 0.0498741553309325 1.05747103634344 0.625 30.1 30 1 abnormal sensory capabilities/reflexes/nociception 0.010255392111018 0.0498741553309325 1.05747103634344 0.625 30.1 30 1 decreased lymphocyte cell number 5.08183491999172e-09 1.64169667058174e-07 1.05747103634344 0.625 30.1 30 1 increased sacral vertebrae number 3.36002396934956e-05 0.000422124223422072 1.05747103634344 0.625 30.1 30 1 increased circulating follicle stimulating hormone level 0.00314638705278044 0.0199151088900543 1.05747103634344 0.625 30.1 30 1 abnormal auditory brainstem response waveform shape 0.00314638705278044 0.0199151088900543 1.05747103634344 0.625 30.1 30 1 abnormal mouth morphology 0.0350018261501826 0.122802598799124 1.05747103634344 0.625 30.1 30 1 disorganized retinal layers 0.0350018261501826 0.122802598799124 1.05747103634344 0.625 30.1 30 1 abnormal extraembryonic endoderm formation 0.0350018261501826 0.122802598799124 1.05747103634344 0.625 30.1 30 1 small pancreas 0.0350018261501826 0.122802598799124 1.05747103634344 0.625 30.1 30 1 abnormal amnion morphology 0.0350018261501826 0.122802598799124 1.05747103634344 0.625 30.1 30 1 blepharitis 0.0350018261501826 0.122802598799124 1.05747103634344 0.625 30.1 30 1 loose skin 0.0350018261501826 0.122802598799124 1.05747103634344 0.625 30.1 30 1 abnormal ear pigmentation 0.132668995156358 0.309826184060518 1.05747103634344 0.625 30.1 30 1 pointed snout 0.132668995156358 0.309826184060518 1.05747103634344 0.625 30.1 30 1 enlarged pituitary gland 0.132668995156358 0.309826184060518 1.05747103634344 0.625 30.1 30 1 increased sensitivity to skin irradiation 0.132668995156358 0.309826184060518 1.05747103634344 0.625 30.1 30 1 dermal cysts 0.132668995156358 0.309826184060518 1.05747103634344 0.625 30.1 30 1 dry eyes 0.132668995156358 0.309826184060518 1.05747103634344 0.625 30.1 30 1 poor grooming 0.132668995156358 0.309826184060518 1.05747103634344 0.625 30.1 30 1 abnormal atrial thrombosis 0.132668995156358 0.309826184060518 1.05747103634344 0.625 30.1 30 1 preneoplasia 0.132668995156358 0.309826184060518 1.05747103634344 0.625 30.1 30 1 vascular smooth muscle hypertrophy 0.132668995156358 0.309826184060518 1.05747103634344 0.625 30.1 30 1 abnormal soft palate morphology 0.132668995156358 0.309826184060518 1.05747103634344 0.625 30.1 30 1 abnormal cellular cholesterol metabolism 0.132668995156358 0.309826184060518 1.05747103634344 0.625 30.1 30 1 calcified muscle 0.132668995156358 0.309826184060518 1.05747103634344 0.625 30.1 30 1 decreased susceptibility to age related obesity 0.132668995156358 0.309826184060518 1.05747103634344 0.625 30.1 30 1 abnormal umbilical artery morphology 0.132668995156358 0.309826184060518 1.05747103634344 0.625 30.1 30 1 increased cardiac output 0.132668995156358 0.309826184060518 1.05747103634344 0.625 30.1 30 1 hair follicle degeneration 0.132668995156358 0.309826184060518 1.05747103634344 0.625 30.1 30 1 abnormal ovary development 0.132668995156358 0.309826184060518 1.05747103634344 0.625 30.1 30 1 elevated level of mitotic sister chromatid exchange 0.132668995156358 0.309826184060518 1.05747103634344 0.625 30.1 30 1 abnormal miscarriage rate 0.132668995156358 0.309826184060518 1.05747103634344 0.625 30.1 30 1 small frontal bone 0.132668995156358 0.309826184060518 1.05747103634344 0.625 30.1 30 1 abnormal canal of Schlemm morphology 0.132668995156358 0.309826184060518 1.05747103634344 0.625 30.1 30 1 abnormal somite size 0.132668995156358 0.309826184060518 1.05747103634344 0.625 30.1 30 1 abnormal vertebral body development 0.132668995156358 0.309826184060518 1.05747103634344 0.625 30.1 30 1 ocular hypertension 0.132668995156358 0.309826184060518 1.05747103634344 0.625 30.1 30 1 hypergranulosis 0.132668995156358 0.309826184060518 1.05747103634344 0.625 30.1 30 1 abnormal epidermal lamellar body morphology 0.132668995156358 0.309826184060518 1.05747103634344 0.625 30.1 30 1 enlarged inguinal lymph nodes 0.132668995156358 0.309826184060518 1.05747103634344 0.625 30.1 30 1 abnormal olfactory bulb mitral cell layer morphology 0.132668995156358 0.309826184060518 1.05747103634344 0.625 30.1 30 1 decreased quadriceps weight 0.132668995156358 0.309826184060518 1.05747103634344 0.625 30.1 30 1 abnormal hepatic vein morphology 0.132668995156358 0.309826184060518 1.05747103634344 0.625 30.1 30 1 anomalous pulmonary venous connection 0.132668995156358 0.309826184060518 1.05747103634344 0.625 30.1 30 1 myocardial trabeculae hypoplasia 0.132668995156358 0.309826184060518 1.05747103634344 0.625 30.1 30 1 delayed suture closure 0.132668995156358 0.309826184060518 1.05747103634344 0.625 30.1 30 1 abnormal visual evoked potential 0.132668995156358 0.309826184060518 1.05747103634344 0.625 30.1 30 1 abnormal heart right ventricle pressure 0.132668995156358 0.309826184060518 1.05747103634344 0.625 30.1 30 1 lung situs inversus 0.132668995156358 0.309826184060518 1.05747103634344 0.625 30.1 30 1 abnormal anterior commissure pars posterior morphology 0.132668995156358 0.309826184060518 1.05747103634344 0.625 30.1 30 1 abnormal bronchiole epithelium morphology 0.132668995156358 0.309826184060518 1.05747103634344 0.625 30.1 30 1 increased airway resistance 0.132668995156358 0.309826184060518 1.05747103634344 0.625 30.1 30 1 absent ureteric bud 0.132668995156358 0.309826184060518 1.05747103634344 0.625 30.1 30 1 absent Reichert's membrane 0.132668995156358 0.309826184060518 1.05747103634344 0.625 30.1 30 1 increased cardiac stroke volume 0.132668995156358 0.309826184060518 1.05747103634344 0.625 30.1 30 1 decreased white adipose tissue mass 0.132668995156358 0.309826184060518 1.05747103634344 0.625 30.1 30 1 increased brain apoptosis 0.132668995156358 0.309826184060518 1.05747103634344 0.625 30.1 30 1 decreased vascular endothelial cell proliferation 0.132668995156358 0.309826184060518 1.05747103634344 0.625 30.1 30 1 decreased body size 1.88896617759607e-48 1.34251524764863e-45 1.0558808543339 0.62406015037594 30.1 30 1 lethargy 6.95704528079751e-07 1.33120385661414e-05 1.05519690508248 0.623655913978495 30.1 30 1 abnormal epidermal layer morphology 1.91275446569451e-05 0.000255805200721242 1.05440590290476 0.623188405797101 30.1 30 1 abnormal long bone morphology 5.82948176869601e-05 0.000676029645670458 1.05400391819149 0.622950819672131 30.1 30 1 abnormal behavior 1.61352937891397e-17 1.82438833184023e-15 1.05290641316498 0.622302158273381 30.1 30 1 abnormal cell migration 0.000554689881224833 0.00469316693723392 1.0527711650708 0.622222222222222 30.1 30 1 abnormal metabolism 0.000554689881224833 0.00469316693723392 1.0527711650708 0.622222222222222 30.1 30 1 lethality at weaning, complete penetrance 0.000554689881224833 0.00469316693723392 1.0527711650708 0.622222222222222 30.1 30 1 decreased width of hypertrophic chondrocyte zone 0.00174255530983767 0.0123317392125781 1.05175497668753 0.621621621621622 30.1 30 1 abnormal humerus morphology 0.00174255530983767 0.0123317392125781 1.05175497668753 0.621621621621622 30.1 30 1 abnormal respiratory electron transport chain 0.00174255530983767 0.0123317392125781 1.05175497668753 0.621621621621622 30.1 30 1 premature death 3.64277002188769e-51 3.02046347648188e-48 1.05133008955863 0.62137049941928 30.1 30 1 increased circulating triglyceride level 9.63987227113563e-10 3.44235995865486e-08 1.05017813264452 0.620689655172414 30.1 30 1 abnormal parietal bone morphology 0.00558376068700514 0.0311426349646256 1.05017813264452 0.620689655172414 30.1 30 1 abnormal axon morphology 1.31575953140134e-07 3.17762314015615e-06 1.04963791755571 0.62037037037037 30.1 30 1 increased monocyte cell number 3.93595834709484e-07 7.99240521501912e-06 1.04901126805269 0.62 30.1 30 1 decreased total body fat amount 2.29100474886178e-20 4.55909945023495e-18 1.04860600969146 0.619760479041916 30.1 30 1 neonatal lethality, incomplete penetrance 4.01534682449091e-16 3.69932415774857e-14 1.04770976523873 0.619230769230769 30.1 30 1 abnormal reproductive system morphology 0.000970321700981259 0.00741800816552331 1.04739988361636 0.619047619047619 30.1 30 1 increased keratinocyte proliferation 0.0184748607334937 0.0783471117065591 1.04739988361636 0.619047619047619 30.1 30 1 embryonic lethality at implantation, complete penetrance 0.0184748607334937 0.0783471117065591 1.04739988361636 0.619047619047619 30.1 30 1 abnormal axial skeleton morphology 1.0716753768008e-05 0.000151897008535156 1.04633976227666 0.618421052631579 30.1 30 1 increased width of hypertrophic chondrocyte zone 0.00306884023862743 0.0195773777869997 1.04503020062175 0.617647058823529 30.1 30 1 neuron degeneration 0.000542685822320262 0.00465493442421259 1.04397140609224 0.617021276595745 30.1 30 1 intracranial hemorrhage 9.91256337640153e-05 0.00108384621533182 1.04337142252553 0.616666666666667 30.1 30 1 abnormal cardiovascular system physiology 8.24569681698981e-09 2.58002148833486e-07 1.04315939825759 0.616541353383459 30.1 30 1 decreased B cell number 7.77073419022393e-13 4.83242532454551e-11 1.04309764361644 0.616504854368932 30.1 30 1 abnormal cornea morphology 1.05055719437019e-05 0.000149329201199763 1.04120225116892 0.615384615384615 30.1 30 1 abnormal snout morphology 0.000304613531484269 0.00282733641629522 1.04120225116892 0.615384615384615 30.1 30 1 abnormal skin condition 0.000304613531484269 0.00282733641629522 1.04120225116892 0.615384615384615 30.1 30 1 abnormal iris morphology 0.00169866265511081 0.0121770125492454 1.04120225116892 0.615384615384615 30.1 30 1 decreased B-1 B cell number 0.00169866265511081 0.0121770125492454 1.04120225116892 0.615384615384615 30.1 30 1 abnormal xiphoid process morphology 0.00993650979110169 0.048560055216828 1.04120225116892 0.615384615384615 30.1 30 1 abnormal kidney cortex morphology 0.00993650979110169 0.048560055216828 1.04120225116892 0.615384615384615 30.1 30 1 abnormal erythrocyte osmotic lysis 0.00993650979110169 0.048560055216828 1.04120225116892 0.615384615384615 30.1 30 1 decreased bone resorption 0.00993650979110169 0.048560055216828 1.04120225116892 0.615384615384615 30.1 30 1 decreased Peyer's patch number 0.00993650979110169 0.048560055216828 1.04120225116892 0.615384615384615 30.1 30 1 short premaxilla 0.0649555528071555 0.195690254680212 1.04120225116892 0.615384615384615 30.1 30 1 absent teeth 0.0649555528071555 0.195690254680212 1.04120225116892 0.615384615384615 30.1 30 1 absent trabeculae carneae 0.0649555528071555 0.195690254680212 1.04120225116892 0.615384615384615 30.1 30 1 abnormal renal/urinary system morphology 0.0649555528071555 0.195690254680212 1.04120225116892 0.615384615384615 30.1 30 1 increased foot pad pigmentation 0.0649555528071555 0.195690254680212 1.04120225116892 0.615384615384615 30.1 30 1 pup cannibalization 0.0649555528071555 0.195690254680212 1.04120225116892 0.615384615384615 30.1 30 1 lymphoid hypoplasia 0.0649555528071555 0.195690254680212 1.04120225116892 0.615384615384615 30.1 30 1 dystrophic cardiac calcinosis 0.0649555528071555 0.195690254680212 1.04120225116892 0.615384615384615 30.1 30 1 abnormal soleus morphology 0.0649555528071555 0.195690254680212 1.04120225116892 0.615384615384615 30.1 30 1 muscle fatigue 0.0649555528071555 0.195690254680212 1.04120225116892 0.615384615384615 30.1 30 1 decreased endocochlear potential 0.0649555528071555 0.195690254680212 1.04120225116892 0.615384615384615 30.1 30 1 increased circulating thyroid-stimulating hormone level 0.0649555528071555 0.195690254680212 1.04120225116892 0.615384615384615 30.1 30 1 orthokeratosis 0.0649555528071555 0.195690254680212 1.04120225116892 0.615384615384615 30.1 30 1 empty decidua capsularis 0.0649555528071555 0.195690254680212 1.04120225116892 0.615384615384615 30.1 30 1 increased prostaglandin level 0.0649555528071555 0.195690254680212 1.04120225116892 0.615384615384615 30.1 30 1 abnormal craniofacial bone morphology 0.000171498969466748 0.00170300872873667 1.03891891289882 0.614035087719298 30.1 30 1 increased circulating cholesterol level 5.81948071396747e-11 2.58499254928466e-09 1.0382442902281 0.613636363636364 30.1 30 1 abnormal myelopoiesis 0.000945491942094828 0.00730520731847034 1.0382442902281 0.613636363636364 30.1 30 1 cochlear hair cell degeneration 0.000945491942094828 0.00730520731847034 1.0382442902281 0.613636363636364 30.1 30 1 abnormal neurocranium morphology 1.8061181877495e-05 0.000242849675244696 1.03773157699836 0.613333333333333 30.1 30 1 increased lung adenoma incidence 0.00541282814168951 0.0304969648979675 1.03700385499486 0.612903225806452 30.1 30 1 increased or absent threshold for auditory brainstem response 6.82131956233424e-17 7.070013504711e-15 1.03624843422997 0.612456747404844 30.1 30 1 organ of Corti degeneration 0.000528631255331957 0.00458490664898153 1.03588999478541 0.612244897959184 30.1 30 1 abnormal epidermis stratum corneum morphology 0.000528631255331957 0.00458490664898153 1.03588999478541 0.612244897959184 30.1 30 1 abnormal bone mineralization 6.9992474097385e-08 1.77659468691067e-06 1.03474851820713 0.611570247933884 30.1 30 1 decreased platelet aggregation 0.000296649403688331 0.00277615475757547 1.03397167998025 0.611111111111111 30.1 30 1 impaired wound healing 0.00297597651663891 0.0190301840234943 1.03397167998025 0.611111111111111 30.1 30 1 lowered ear position 0.0334793669023719 0.12101133538197 1.03397167998025 0.611111111111111 30.1 30 1 right pulmonary isomerism 0.0334793669023719 0.12101133538197 1.03397167998025 0.611111111111111 30.1 30 1 abnormal mammary gland morphology 0.0334793669023719 0.12101133538197 1.03397167998025 0.611111111111111 30.1 30 1 abnormal retinal rod cell morphology 0.0334793669023719 0.12101133538197 1.03397167998025 0.611111111111111 30.1 30 1 abnormal thyroid cartilage morphology 0.0334793669023719 0.12101133538197 1.03397167998025 0.611111111111111 30.1 30 1 abnormal thymus medulla morphology 0.0334793669023719 0.12101133538197 1.03397167998025 0.611111111111111 30.1 30 1 decreased lactate dehydrogenase level 0.0334793669023719 0.12101133538197 1.03397167998025 0.611111111111111 30.1 30 1 decreased pulmonary respiratory rate 0.0334793669023719 0.12101133538197 1.03397167998025 0.611111111111111 30.1 30 1 small thoracic cage 0.0334793669023719 0.12101133538197 1.03397167998025 0.611111111111111 30.1 30 1 increased effector memory CD4-positive, alpha-beta T cell number 0.0334793669023719 0.12101133538197 1.03397167998025 0.611111111111111 30.1 30 1 increased adipocyte glucose uptake 0.0334793669023719 0.12101133538197 1.03397167998025 0.611111111111111 30.1 30 1 syndactyly 0.000166980302391577 0.00166812651485561 1.03237850327766 0.610169491525424 30.1 30 1 abnormal thoracic vertebrae morphology 0.000166980302391577 0.00166812651485561 1.03237850327766 0.610169491525424 30.1 30 1 increased hemoglobin content 0.000166980302391577 0.00166812651485561 1.03237850327766 0.610169491525424 30.1 30 1 increased tumor growth/size 0.00164771358354809 0.0118459177429939 1.03167905984726 0.609756097560976 30.1 30 1 decreased circulating LDL cholesterol level 9.42350581605644e-05 0.0010349214444786 1.03103426043485 0.609375 30.1 30 1 abnormal nervous system physiology 2.03196091139504e-07 4.61598426218736e-06 1.02988483539535 0.608695652173913 30.1 30 1 abnormal locomotor behavior 3.24937938757286e-06 5.40657607129597e-05 1.02988483539535 0.608695652173913 30.1 30 1 delayed wound healing 0.00091732867778319 0.00712770323779856 1.02988483539535 0.608695652173913 30.1 30 1 abnormal blood vessel physiology 0.0177382248084421 0.0778198134232799 1.02988483539535 0.608695652173913 30.1 30 1 abnormal cranial nerve morphology 0.0177382248084421 0.0778198134232799 1.02988483539535 0.608695652173913 30.1 30 1 abnormal cochlear ganglion morphology 0.0177382248084421 0.0778198134232799 1.02988483539535 0.608695652173913 30.1 30 1 dilated heart 0.0177382248084421 0.0778198134232799 1.02988483539535 0.608695652173913 30.1 30 1 abnormal palatal shelf fusion at midline 0.0177382248084421 0.0778198134232799 1.02988483539535 0.608695652173913 30.1 30 1 abnormal vertebral artery topology 0.0177382248084421 0.0778198134232799 1.02988483539535 0.608695652173913 30.1 30 1 liver inflammation 1.16358036605402e-07 2.85163168528018e-06 1.02927180870761 0.608333333333333 30.1 30 1 abnormal cervical vertebrae morphology 0.000512971273214792 0.00449301423282322 1.0284424196595 0.607843137254902 30.1 30 1 cochlear inner hair cell degeneration 0.000512971273214792 0.00449301423282322 1.0284424196595 0.607843137254902 30.1 30 1 hypoactivity 9.03559969265679e-21 1.95443949873772e-18 1.02773842895553 0.607427055702918 30.1 30 1 increased B cell number 1.9790599599822e-07 4.51643270684011e-06 1.02674110879158 0.606837606837607 30.1 30 1 insulin resistance 3.72053006418544e-08 9.84555163261839e-07 1.02542645948455 0.606060606060606 30.1 30 1 abnormal tail morphology 9.14737725547841e-05 0.00100681862491162 1.02542645948455 0.606060606060606 30.1 30 1 dextrocardia 0.00521766346721855 0.0299813323747206 1.02542645948455 0.606060606060606 30.1 30 1 abnormal locomotor coordination 0.00521766346721855 0.0299813323747206 1.02542645948455 0.606060606060606 30.1 30 1 retinal degeneration 3.06921545649446e-06 5.1585631405608e-05 1.02222200179866 0.604166666666667 30.1 30 1 abnormal coat/ hair morphology 0.000496093204127651 0.00437951003795831 1.02155692567517 0.60377358490566 30.1 30 1 abnormal enzyme/coenzyme level 0.000278550881660397 0.00263458295867011 1.02100651784884 0.603448275862069 30.1 30 1 increased sensitivity to induced morbidity/mortality 1.40900410125736e-10 5.89058437290366e-09 1.02068943507932 0.603260869565217 30.1 30 1 increased liver weight 9.16882151872129e-06 0.000135677649248344 1.01901754411277 0.602272727272727 30.1 30 1 decreased circulating HDL cholesterol level 1.03746436968405e-07 2.55514120751394e-06 1.01781587248056 0.6015625 30.1 30 1 female infertility 1.96897733309086e-14 1.50702495878877e-12 1.01771648610496 0.601503759398496 30.1 30 1 postnatal lethality, complete penetrance 3.38676163734716e-20 6.24042190585263e-18 1.0169255147427 0.601036269430052 30.1 30 1 abnormal testis morphology 5.36070610556399e-07 1.04998082185751e-05 1.0151721948897 0.6 30.1 30 1 spleen hypoplasia 1.64241448201699e-06 2.97127710837619e-05 1.0151721948897 0.6 30.1 30 1 abnormal lactation 0.00915417216456937 0.0456790436496816 1.0151721948897 0.6 30.1 30 1 liver hemorrhage 0.00915417216456937 0.0456790436496816 1.0151721948897 0.6 30.1 30 1 interdigital webbing 0.0611180167228834 0.187576886610947 1.0151721948897 0.6 30.1 30 1 vagina atresia 0.0611180167228834 0.187576886610947 1.0151721948897 0.6 30.1 30 1 absent egg cylinders 0.0611180167228834 0.187576886610947 1.0151721948897 0.6 30.1 30 1 abnormal lymph node B cell domain morphology 0.0611180167228834 0.187576886610947 1.0151721948897 0.6 30.1 30 1 abnormal ear development 0.0611180167228834 0.187576886610947 1.0151721948897 0.6 30.1 30 1 abnormal neurotransmitter secretion 0.0611180167228834 0.187576886610947 1.0151721948897 0.6 30.1 30 1 abnormal secondary palate development 0.0611180167228834 0.187576886610947 1.0151721948897 0.6 30.1 30 1 abnormal aorta wall morphology 0.0611180167228834 0.187576886610947 1.0151721948897 0.6 30.1 30 1 abnormal coronary vessel morphology 0.0611180167228834 0.187576886610947 1.0151721948897 0.6 30.1 30 1 decreased oocyte number 0.000854203821352856 0.00680250438622837 1.0151721948897 0.6 30.1 30 1 decreased respiratory quotient 0.000854203821352856 0.00680250438622837 1.0151721948897 0.6 30.1 30 1 albuminuria 0.00153169503339982 0.0110437431756001 1.0151721948897 0.6 30.1 30 1 decreased osteoclast cell number 0.00153169503339982 0.0110437431756001 1.0151721948897 0.6 30.1 30 1 decreased circulating phosphate level 0.00276038365193173 0.0178349463225459 1.0151721948897 0.6 30.1 30 1 abnormal intestinal goblet cell morphology 0.00500628658038971 0.0292670690216672 1.0151721948897 0.6 30.1 30 1 decreased circulating thyroxine level 0.00500628658038971 0.0292670690216672 1.0151721948897 0.6 30.1 30 1 impaired adaptive thermogenesis 0.00500628658038971 0.0292670690216672 1.0151721948897 0.6 30.1 30 1 abnormal cochlear outer hair cell morphology 0.0169239866593489 0.074708814223834 1.0151721948897 0.6 30.1 30 1 increased liver glycogen level 0.0169239866593489 0.074708814223834 1.0151721948897 0.6 30.1 30 1 abnormal basioccipital bone morphology 0.031780156431524 0.117551136242998 1.0151721948897 0.6 30.1 30 1 abnormal cell proliferation 0.031780156431524 0.117551136242998 1.0151721948897 0.6 30.1 30 1 abnormal vascular regression 0.031780156431524 0.117551136242998 1.0151721948897 0.6 30.1 30 1 brain inflammation 0.031780156431524 0.117551136242998 1.0151721948897 0.6 30.1 30 1 abnormal dopamine level 0.031780156431524 0.117551136242998 1.0151721948897 0.6 30.1 30 1 abnormal hair texture 0.031780156431524 0.117551136242998 1.0151721948897 0.6 30.1 30 1 abnormal Peyer's patch T cell area morphology 0.031780156431524 0.117551136242998 1.0151721948897 0.6 30.1 30 1 abnormal lens epithelium morphology 0.031780156431524 0.117551136242998 1.0151721948897 0.6 30.1 30 1 abnormal physiological neovascularization 0.031780156431524 0.117551136242998 1.0151721948897 0.6 30.1 30 1 kidney atrophy 0.031780156431524 0.117551136242998 1.0151721948897 0.6 30.1 30 1 abnormal induced retinal neovascularization 0.031780156431524 0.117551136242998 1.0151721948897 0.6 30.1 30 1 abnormal neuron proliferation 0.031780156431524 0.117551136242998 1.0151721948897 0.6 30.1 30 1 abnormal lateral semicircular canal morphology 0.122512882784981 0.309826184060518 1.0151721948897 0.6 30.1 30 1 abnormal otic capsule morphology 0.122512882784981 0.309826184060518 1.0151721948897 0.6 30.1 30 1 increased cranium width 0.122512882784981 0.309826184060518 1.0151721948897 0.6 30.1 30 1 abnormal prostate gland epithelium morphology 0.122512882784981 0.309826184060518 1.0151721948897 0.6 30.1 30 1 abnormal epidermis suprabasal layer morphology 0.122512882784981 0.309826184060518 1.0151721948897 0.6 30.1 30 1 abnormal immune cell physiology 0.122512882784981 0.309826184060518 1.0151721948897 0.6 30.1 30 1 abnormal mammary gland physiology 0.122512882784981 0.309826184060518 1.0151721948897 0.6 30.1 30 1 abnormal gland morphology 0.122512882784981 0.309826184060518 1.0151721948897 0.6 30.1 30 1 decreased circulating parathyroid hormone level 0.122512882784981 0.309826184060518 1.0151721948897 0.6 30.1 30 1 intestinal edema 0.122512882784981 0.309826184060518 1.0151721948897 0.6 30.1 30 1 intestinal hypoperistalsis 0.122512882784981 0.309826184060518 1.0151721948897 0.6 30.1 30 1 absent seminal vesicle 0.122512882784981 0.309826184060518 1.0151721948897 0.6 30.1 30 1 absent CD4-positive, alpha beta T cells 0.122512882784981 0.309826184060518 1.0151721948897 0.6 30.1 30 1 increased atrioventricular cushion size 0.122512882784981 0.309826184060518 1.0151721948897 0.6 30.1 30 1 abnormal pillar cell morphology 0.122512882784981 0.309826184060518 1.0151721948897 0.6 30.1 30 1 abnormal hindlimb zeugopod morphology 0.122512882784981 0.309826184060518 1.0151721948897 0.6 30.1 30 1 absent inguinal lymph nodes 0.122512882784981 0.309826184060518 1.0151721948897 0.6 30.1 30 1 absent axillary lymph nodes 0.122512882784981 0.309826184060518 1.0151721948897 0.6 30.1 30 1 abnormal spinal cord dorsal column morphology 0.122512882784981 0.309826184060518 1.0151721948897 0.6 30.1 30 1 increased serotonin level 0.122512882784981 0.309826184060518 1.0151721948897 0.6 30.1 30 1 increased kidney iron level 0.122512882784981 0.309826184060518 1.0151721948897 0.6 30.1 30 1 sinus bradycardia 0.122512882784981 0.309826184060518 1.0151721948897 0.6 30.1 30 1 decreased macrophage apoptosis 0.122512882784981 0.309826184060518 1.0151721948897 0.6 30.1 30 1 abnormal spermatogenesis 3.64502942526061e-10 1.42787570005288e-08 1.01149403476329 0.597826086956522 30.1 30 1 polyuria 4.66898422739013e-05 0.000561067549064394 1.01077751006334 0.597402597402597 30.1 30 1 abnormal heart left ventricle morphology 8.24430579422554e-05 0.000917570946896467 1.01047232361706 0.597222222222222 30.1 30 1 decreased compact bone thickness 0.000145865106338275 0.00150840465830985 1.01012158695493 0.597014925373134 30.1 30 1 maternal effect 0.000145865106338275 0.00150840465830985 1.01012158695493 0.597014925373134 30.1 30 1 abnormal vertebrae morphology 1.53155296068867e-06 2.80127793361255e-05 1.00896319063961 0.596330275229358 30.1 30 1 abnormal motor coordination/ balance 4.70304422211719e-06 7.4752859441e-05 1.00833601849314 0.595959595959596 30.1 30 1 cleft secondary palate 8.2534687467554e-06 0.000124051380710296 1.00797239208906 0.595744680851064 30.1 30 1 abnormal tibia morphology 0.00146943393846539 0.0106877687775808 1.00797239208906 0.595744680851064 30.1 30 1 abnormal pancreas morphology 0.00264387811673463 0.0172842229050654 1.00711527270804 0.595238095238095 30.1 30 1 increased erythroid progenitor cell number 0.00478499428661404 0.0283060006847858 1.00602649944024 0.594594594594595 30.1 30 1 abnormal hair follicle development 0.00478499428661404 0.0283060006847858 1.00602649944024 0.594594594594595 30.1 30 1 skin inflammation 0.00478499428661404 0.0283060006847858 1.00602649944024 0.594594594594595 30.1 30 1 polydipsia 0.00872531896394124 0.0440877133788154 1.00459748452627 0.59375 30.1 30 1 abnormal diaphragm morphology 0.00872531896394124 0.0440877133788154 1.00459748452627 0.59375 30.1 30 1 abnormal lumbar vertebrae morphology 0.00872531896394124 0.0440877133788154 1.00459748452627 0.59375 30.1 30 1 bradykinesia 0.00872531896394124 0.0440877133788154 1.00459748452627 0.59375 30.1 30 1 abnormal colon morphology 0.000441257976427426 0.0039271170531779 1.00370132263106 0.593220338983051 30.1 30 1 increased leukocyte cell number 4.82414425179018e-08 1.25655066244273e-06 1.00350354897143 0.593103448275862 30.1 30 1 impaired glucose tolerance 1.12760428775544e-12 6.67837063283727e-11 1.00289188608055 0.592741935483871 30.1 30 1 abnormal rib morphology 1.46729441703684e-07 3.47609034512299e-06 1.00263920482933 0.592592592592593 30.1 30 1 diluted coat color 0.00078619327749393 0.0063598561878574 1.00263920482933 0.592592592592593 30.1 30 1 decreased tumor growth/size 0.00078619327749393 0.0063598561878574 1.00263920482933 0.592592592592593 30.1 30 1 axon degeneration 0.00078619327749393 0.0063598561878574 1.00263920482933 0.592592592592593 30.1 30 1 rectal prolapse 0.0160691742412873 0.0711246813615698 1.00263920482933 0.592592592592593 30.1 30 1 abnormal trigeminal ganglion morphology 0.0160691742412873 0.0711246813615698 1.00263920482933 0.592592592592593 30.1 30 1 wrinkled skin 0.0160691742412873 0.0711246813615698 1.00263920482933 0.592592592592593 30.1 30 1 increased brain weight 0.0160691742412873 0.0711246813615698 1.00263920482933 0.592592592592593 30.1 30 1 decreased bone ossification 0.0160691742412873 0.0711246813615698 1.00263920482933 0.592592592592593 30.1 30 1 abnormal enzyme/coenzyme activity 1.52956046052427e-08 4.42416470413269e-07 1.00224006501849 0.592356687898089 30.1 30 1 increased circulating LDL cholesterol level 0.00140581018430341 0.0103767146393316 1.00136032829256 0.591836734693878 30.1 30 1 abnormal ovary morphology 0.000134491819455094 0.00140271866203164 1.00087399496168 0.591549295774648 30.1 30 1 hypertension 0.00252473500295783 0.0167028678719617 0.999790797997432 0.590909090909091 30.1 30 1 renal interstitial fibrosis 0.00252473500295783 0.0167028678719617 0.999790797997432 0.590909090909091 30.1 30 1 decreased sensitivity to induced morbidity/mortality 0.00252473500295783 0.0167028678719617 0.999790797997432 0.590909090909091 30.1 30 1 embryonic lethality, incomplete penetrance 0.00252473500295783 0.0167028678719617 0.999790797997432 0.590909090909091 30.1 30 1 abnormal facial nerve morphology 0.0300037884573669 0.112485943915147 0.999790797997432 0.590909090909091 30.1 30 1 abnormal tail movements 0.0300037884573669 0.112485943915147 0.999790797997432 0.590909090909091 30.1 30 1 intestinal inflammation 0.0300037884573669 0.112485943915147 0.999790797997432 0.590909090909091 30.1 30 1 aphakia 0.0300037884573669 0.112485943915147 0.999790797997432 0.590909090909091 30.1 30 1 abnormal retinal layer morphology 0.0300037884573669 0.112485943915147 0.999790797997432 0.590909090909091 30.1 30 1 decreased circulating estradiol level 0.0300037884573669 0.112485943915147 0.999790797997432 0.590909090909091 30.1 30 1 short tail 4.14203763326408e-05 0.000503829761014396 0.998864207823199 0.590361445783133 30.1 30 1 abnormal lipid level 4.14203763326408e-05 0.000503829761014396 0.998864207823199 0.590361445783133 30.1 30 1 acanthosis 0.00455870049415025 0.0270962185882885 0.997818824036885 0.58974358974359 30.1 30 1 increased autoantibody level 0.00455870049415025 0.0270962185882885 0.997818824036885 0.58974358974359 30.1 30 1 impaired macrophage chemotaxis 0.00455870049415025 0.0270962185882885 0.997818824036885 0.58974358974359 30.1 30 1 abnormal response to injury 0.00455870049415025 0.0270962185882885 0.997818824036885 0.58974358974359 30.1 30 1 abnormal cranium morphology 2.36464102746054e-07 5.13715681729965e-06 0.997495067117989 0.58955223880597 30.1 30 1 decreased birth weight 1.28539358843513e-05 0.000178626622973876 0.997362156382863 0.589473684210526 30.1 30 1 abnormal coat/hair pigmentation 2.29282136248293e-06 4.0306665294532e-05 0.997044119980955 0.589285714285714 30.1 30 1 abnormal eye development 0.000751558426849091 0.00612155245548514 0.997044119980955 0.589285714285714 30.1 30 1 decreased percent body fat/body weight 0.000128790625797715 0.00135175815051399 0.996630236992171 0.589041095890411 30.1 30 1 decreased grip strength 4.78496600771615e-11 2.16410962621708e-09 0.996630236992171 0.589041095890411 30.1 30 1 abnormal oocyte morphology 0.00828741093663443 0.0423304614063206 0.995266857735 0.588235294117647 30.1 30 1 abnormal skin physiology 0.00828741093663443 0.0423304614063206 0.995266857735 0.588235294117647 30.1 30 1 enlarged sebaceous gland 0.0571714742994282 0.176444221240481 0.995266857735 0.588235294117647 30.1 30 1 abnormal duodenum morphology 0.0571714742994282 0.176444221240481 0.995266857735 0.588235294117647 30.1 30 1 increased brain size 0.0571714742994282 0.176444221240481 0.995266857735 0.588235294117647 30.1 30 1 increased circulating magnesium level 0.0571714742994282 0.176444221240481 0.995266857735 0.588235294117647 30.1 30 1 abnormal circulating chemokine level 0.0571714742994282 0.176444221240481 0.995266857735 0.588235294117647 30.1 30 1 abnormal electroretinogram waveform feature 0.0571714742994282 0.176444221240481 0.995266857735 0.588235294117647 30.1 30 1 abnormal ductus venosus valve morphology 0.0571714742994282 0.176444221240481 0.995266857735 0.588235294117647 30.1 30 1 distended abdomen 0.00134167889012151 0.00993281618802758 0.995266857735 0.588235294117647 30.1 30 1 decreased IgM level 1.23143413604214e-05 0.000171607418117917 0.994240809428057 0.587628865979381 30.1 30 1 abnormal myelin sheath morphology 0.00240474195980241 0.0159941059492206 0.993103234131228 0.58695652173913 30.1 30 1 impaired coordination 2.86072296965039e-16 2.68530127811522e-14 0.992678013307366 0.586705202312139 30.1 30 1 abnormal microglial cell morphology 0.015199898711005 0.0688075487600091 0.991834903053155 0.586206896551724 30.1 30 1 abnormal circulating glucose level 0.015199898711005 0.0688075487600091 0.991834903053155 0.586206896551724 30.1 30 1 abnormal spinal nerve morphology 0.015199898711005 0.0688075487600091 0.991834903053155 0.586206896551724 30.1 30 1 enlarged epididymis 0.015199898711005 0.0688075487600091 0.991834903053155 0.586206896551724 30.1 30 1 decreased bone strength 0.015199898711005 0.0688075487600091 0.991834903053155 0.586206896551724 30.1 30 1 abnormal lens morphology 6.61284628593916e-07 1.27022819585125e-05 0.991379096571973 0.5859375 30.1 30 1 deafness 1.17830999191561e-05 0.000164665511510679 0.991245577501727 0.585858585858586 30.1 30 1 abnormal cholesterol homeostasis 0.00433121198376745 0.025898773580821 0.990411897453366 0.585365853658537 30.1 30 1 palatal shelves fail to meet at midline 0.00433121198376745 0.025898773580821 0.990411897453366 0.585365853658537 30.1 30 1 abnormal long bone epiphyseal plate morphology 0.000682751915959742 0.00560510030016455 0.986972967253875 0.583333333333333 30.1 30 1 abnormal intestinal epithelium morphology 0.00228531259258279 0.0154475953099177 0.986972967253875 0.583333333333333 30.1 30 1 vertebral transformation 0.00228531259258279 0.0154475953099177 0.986972967253875 0.583333333333333 30.1 30 1 blindness 0.0282141905848358 0.110404693021963 0.986972967253875 0.583333333333333 30.1 30 1 abnormal cardiac muscle contractility 0.0282141905848358 0.110404693021963 0.986972967253875 0.583333333333333 30.1 30 1 prolonged QT interval 0.0282141905848358 0.110404693021963 0.986972967253875 0.583333333333333 30.1 30 1 decreased ovulation rate 0.0282141905848358 0.110404693021963 0.986972967253875 0.583333333333333 30.1 30 1 abnormal retinal ganglion layer morphology 0.0282141905848358 0.110404693021963 0.986972967253875 0.583333333333333 30.1 30 1 abnormal esophagus morphology 0.11261475031923 0.295806960315824 0.986972967253875 0.583333333333333 30.1 30 1 absent optic nerve 0.11261475031923 0.295806960315824 0.986972967253875 0.583333333333333 30.1 30 1 abnormal pilomotor reflex 0.11261475031923 0.295806960315824 0.986972967253875 0.583333333333333 30.1 30 1 myocarditis 0.11261475031923 0.295806960315824 0.986972967253875 0.583333333333333 30.1 30 1 altered tumor susceptibility 0.11261475031923 0.295806960315824 0.986972967253875 0.583333333333333 30.1 30 1 increased growth rate 0.11261475031923 0.295806960315824 0.986972967253875 0.583333333333333 30.1 30 1 decreased synaptic depression 0.11261475031923 0.295806960315824 0.986972967253875 0.583333333333333 30.1 30 1 decreased circulating ketone body level 0.11261475031923 0.295806960315824 0.986972967253875 0.583333333333333 30.1 30 1 delayed somite formation 0.11261475031923 0.295806960315824 0.986972967253875 0.583333333333333 30.1 30 1 abnormal nucleotide metabolism 0.11261475031923 0.295806960315824 0.986972967253875 0.583333333333333 30.1 30 1 decreased left ventricle systolic pressure 0.11261475031923 0.295806960315824 0.986972967253875 0.583333333333333 30.1 30 1 absent cochlear hair cells 0.11261475031923 0.295806960315824 0.986972967253875 0.583333333333333 30.1 30 1 small parietal bone 0.11261475031923 0.295806960315824 0.986972967253875 0.583333333333333 30.1 30 1 abnormal B cell proliferation 0.11261475031923 0.295806960315824 0.986972967253875 0.583333333333333 30.1 30 1 hematuria 0.11261475031923 0.295806960315824 0.986972967253875 0.583333333333333 30.1 30 1 decreased keratinocyte proliferation 0.11261475031923 0.295806960315824 0.986972967253875 0.583333333333333 30.1 30 1 hydrometra 0.11261475031923 0.295806960315824 0.986972967253875 0.583333333333333 30.1 30 1 reduced cerebellar foliation 0.11261475031923 0.295806960315824 0.986972967253875 0.583333333333333 30.1 30 1 abnormal gait 3.40871566379212e-14 2.42262291819511e-12 0.985604072708447 0.58252427184466 30.1 30 1 abnormal femur morphology 0.000366477935808043 0.00329697600478303 0.984868547281052 0.582089552238806 30.1 30 1 increased circulating calcium level 0.00121452295796773 0.00903176639146407 0.984409401105164 0.581818181818182 30.1 30 1 abnormal contextual conditioning behavior 0.00121452295796773 0.00903176639146407 0.984409401105164 0.581818181818182 30.1 30 1 abnormal homeostasis 0.00410545061006218 0.0247571112546174 0.983693987296221 0.581395348837209 30.1 30 1 abnormal double-strand DNA break repair 0.00410545061006218 0.0247571112546174 0.983693987296221 0.581395348837209 30.1 30 1 absent mature ovarian follicles 0.0143344946577876 0.0653059623832354 0.982424704731968 0.580645161290323 30.1 30 1 abnormal object recognition memory 0.0143344946577876 0.0653059623832354 0.982424704731968 0.580645161290323 30.1 30 1 abnormal neuron differentiation 5.59633186213283e-06 8.75526761450025e-05 0.981937390890335 0.580357142857143 30.1 30 1 abnormal hindlimb morphology 0.00216755230456845 0.0147986272685151 0.98133312172671 0.58 30.1 30 1 kidney inflammation 0.00216755230456845 0.0147986272685151 0.98133312172671 0.58 30.1 30 1 abnormal circulating protein level 0.00216755230456845 0.0147986272685151 0.98133312172671 0.58 30.1 30 1 abnormal trabecular bone morphology 3.0576237353905e-06 5.1565010452772e-05 0.981048759767357 0.579831932773109 30.1 30 1 hyperkeratosis 0.000348453888872488 0.00318084054521216 0.980842700376522 0.579710144927536 30.1 30 1 teratozoospermia 5.78067092939152e-05 0.000671935464339318 0.980564051882097 0.579545454545455 30.1 30 1 infertility 9.77217091870399e-06 0.000141327181164396 0.980384362666066 0.579439252336449 30.1 30 1 neonatal lethality, complete penetrance 1.25775956141437e-19 2.08578460601216e-17 0.979552117876026 0.578947368421053 30.1 30 1 abnormal blood homeostasis 5.3321744586959e-06 8.36831795962527e-05 0.979552117876026 0.578947368421053 30.1 30 1 increased bone marrow cell number 0.00741534560149853 0.0380323137808816 0.979552117876026 0.578947368421053 30.1 30 1 abnormal retinal outer nuclear layer morphology 0.00741534560149853 0.0380323137808816 0.979552117876026 0.578947368421053 30.1 30 1 impaired branching involved in ureteric bud morphogenesis 0.00741534560149853 0.0380323137808816 0.979552117876026 0.578947368421053 30.1 30 1 abnormal nail morphology 0.053276594141604 0.165968100096731 0.979552117876026 0.578947368421053 30.1 30 1 decreased germ cell number 0.053276594141604 0.165968100096731 0.979552117876026 0.578947368421053 30.1 30 1 increased susceptibility to ischemic brain injury 0.053276594141604 0.165968100096731 0.979552117876026 0.578947368421053 30.1 30 1 abnormal sternebra morphology 0.053276594141604 0.165968100096731 0.979552117876026 0.578947368421053 30.1 30 1 abnormal cochlear inner hair cell morphology 0.053276594141604 0.165968100096731 0.979552117876026 0.578947368421053 30.1 30 1 decreased susceptibility to weight gain 0.053276594141604 0.165968100096731 0.979552117876026 0.578947368421053 30.1 30 1 decreased liver glycogen level 0.053276594141604 0.165968100096731 0.979552117876026 0.578947368421053 30.1 30 1 respiratory distress 2.62529089119588e-08 7.16041574505297e-07 0.978007894884104 0.578034682080925 30.1 30 1 weight loss 2.50127782768752e-08 6.95187552667341e-07 0.976498968417711 0.577142857142857 30.1 30 1 cachexia 1.62409554401746e-05 0.00022258609728614 0.976127110470866 0.576923076923077 30.1 30 1 eyelids open at birth 0.00205231330319912 0.0141416325255064 0.976127110470866 0.576923076923077 30.1 30 1 abnormal nasal bone morphology 0.0264523642069588 0.10436202373483 0.976127110470866 0.576923076923077 30.1 30 1 absent gastric milk in neonates 0.000178322911095151 0.001767243989439 0.976127110470865 0.576923076923077 30.1 30 1 impaired swimming 0.000584123535458349 0.0048758634042035 0.974155136510318 0.575757575757576 30.1 30 1 abnormal tooth development 0.0134857085666363 0.0616082645720986 0.974155136510318 0.575757575757576 30.1 30 1 no abnormal phenotype detected 6.20706052249143e-70 1.0293375366465e-66 0.973239049471585 0.57521613832853 30.1 30 1 increased circulating insulin level 1.30161418391048e-07 3.15879539753886e-06 0.972873353435962 0.575 30.1 30 1 abnormal retinal pigment epithelium morphology 0.000169182994251267 0.00168337079280011 0.972873353435962 0.575 30.1 30 1 abnormal spleen morphology 3.92450396248082e-08 1.03303741869535e-06 0.972387159856035 0.574712643678161 30.1 30 1 increased systemic arterial blood pressure 0.00366740778860737 0.0222504314003923 0.971973378085883 0.574468085106383 30.1 30 1 abnormal osteoblast physiology 0.00194024039209482 0.0134416067699359 0.971306729678417 0.574074074074074 30.1 30 1 abnormal maternal nurturing 0.00103323278265409 0.00775314192112231 0.970793082544795 0.573770491803279 30.1 30 1 decreased circulating alanine transaminase level 0.000553075577245647 0.00469316693723392 0.970385186291625 0.573529411764706 30.1 30 1 abnormal urine homeostasis 4.70283399114265e-05 0.000563773472432161 0.969348449981485 0.572916666666667 30.1 30 1 reduced male fertility 5.40295745136837e-10 2.03634191822406e-08 0.96896024475522 0.572687224669604 30.1 30 1 decreased neutrophil cell number 7.58141602543734e-06 0.000114992514410216 0.968896539282192 0.572649572649573 30.1 30 1 decreased exploration in new environment 0.000151832086527643 0.00154156047035719 0.966830661799714 0.571428571428571 30.1 30 1 decreased urine osmolality 0.00345798247028867 0.0210054490716558 0.966830661799714 0.571428571428571 30.1 30 1 abnormal cartilage morphology 0.00658099047314456 0.0358602711981316 0.966830661799714 0.571428571428571 30.1 30 1 skin edema 0.00658099047314456 0.0358602711981316 0.966830661799714 0.571428571428571 30.1 30 1 abnormal vibrissa morphology 0.00658099047314456 0.0358602711981316 0.966830661799714 0.571428571428571 30.1 30 1 abnormal muscle morphology 0.00658099047314456 0.0358602711981316 0.966830661799714 0.571428571428571 30.1 30 1 increased circulating serum albumin level 0.0126622434116274 0.0580949405038292 0.966830661799714 0.571428571428571 30.1 30 1 decreased bone mineralization 0.0126622434116274 0.0580949405038292 0.966830661799714 0.571428571428571 30.1 30 1 shortened head 0.0247442701854797 0.0977005906133028 0.966830661799714 0.571428571428571 30.1 30 1 reddish skin 0.0247442701854797 0.0977005906133028 0.966830661799714 0.571428571428571 30.1 30 1 abnormal retinal inner nuclear layer morphology 0.0247442701854797 0.0977005906133028 0.966830661799714 0.571428571428571 30.1 30 1 small ears 0.0495205506955646 0.160675046241915 0.966830661799714 0.571428571428571 30.1 30 1 abnormal salivary gland morphology 0.0495205506955646 0.160675046241915 0.966830661799714 0.571428571428571 30.1 30 1 abnormal hematopoietic system physiology 0.0495205506955646 0.160675046241915 0.966830661799714 0.571428571428571 30.1 30 1 decreased cochlear outer hair cell number 0.0495205506955646 0.160675046241915 0.966830661799714 0.571428571428571 30.1 30 1 abnormal clavicle morphology 0.0495205506955646 0.160675046241915 0.966830661799714 0.571428571428571 30.1 30 1 abnormal placing response 0.103308293336972 0.274991310514411 0.966830661799714 0.571428571428571 30.1 30 1 abnormal adrenal gland secretion 0.103308293336972 0.274991310514411 0.966830661799714 0.571428571428571 30.1 30 1 abnormal antigen presentation 0.103308293336972 0.274991310514411 0.966830661799714 0.571428571428571 30.1 30 1 abnormal kidney medulla morphology 0.103308293336972 0.274991310514411 0.966830661799714 0.571428571428571 30.1 30 1 decreased coping response 0.103308293336972 0.274991310514411 0.966830661799714 0.571428571428571 30.1 30 1 decreased vascular permeability 0.103308293336972 0.274991310514411 0.966830661799714 0.571428571428571 30.1 30 1 abnormal voluntary movement 0.103308293336972 0.274991310514411 0.966830661799714 0.571428571428571 30.1 30 1 abnormal pancreas development 0.103308293336972 0.274991310514411 0.966830661799714 0.571428571428571 30.1 30 1 abnormal glucose tolerance 0.103308293336972 0.274991310514411 0.966830661799714 0.571428571428571 30.1 30 1 decreased cornea thickness 0.103308293336972 0.274991310514411 0.966830661799714 0.571428571428571 30.1 30 1 increased pulmonary respiratory rate 0.103308293336972 0.274991310514411 0.966830661799714 0.571428571428571 30.1 30 1 decreased tongue size 0.103308293336972 0.274991310514411 0.966830661799714 0.571428571428571 30.1 30 1 increased stomach tumor incidence 0.103308293336972 0.274991310514411 0.966830661799714 0.571428571428571 30.1 30 1 abnormal spatial learning 1.83329908723747e-07 4.25067463469952e-06 0.965347792686525 0.570552147239264 30.1 30 1 decreased double-positive T cell number 4.22006567344521e-05 0.000509583172946358 0.964413585145215 0.57 30.1 30 1 decreased B cell proliferation 0.000266022683982922 0.00253536944983724 0.963771071097816 0.569620253164557 30.1 30 1 dermatitis 0.00172735670418258 0.012276570861869 0.962663288257474 0.568965517241379 30.1 30 1 cochlear ganglion degeneration 0.00172735670418258 0.012276570861869 0.962663288257474 0.568965517241379 30.1 30 1 abnormal response to novel object 0.00325620362361213 0.0200396348041041 0.9620912958105 0.568627450980392 30.1 30 1 abnormal thrombosis 0.00325620362361213 0.0200396348041041 0.9620912958105 0.568627450980392 30.1 30 1 alopecia 7.35547284799703e-05 0.000831669941336028 0.96174207936919 0.568421052631579 30.1 30 1 abnormal motor capabilities/coordination/movement 3.33891568974712e-06 5.50036607830858e-05 0.961337305766761 0.568181818181818 30.1 30 1 small seminiferous tubules 0.000466544113129614 0.00413735643996405 0.960298022192959 0.567567567567568 30.1 30 1 abnormal long bone metaphysis morphology 0.0118698615473636 0.0557625695921942 0.960298022192959 0.567567567567568 30.1 30 1 impaired skeletal muscle contractility 0.0118698615473636 0.0557625695921942 0.960298022192959 0.567567567567568 30.1 30 1 abnormal calcium ion homeostasis 0.0118698615473636 0.0557625695921942 0.960298022192959 0.567567567567568 30.1 30 1 delayed eyelid opening 0.0231058488101901 0.0915948986698772 0.95877373961805 0.566666666666667 30.1 30 1 abnormal response to new environment 0.0231058488101901 0.0915948986698772 0.95877373961805 0.566666666666667 30.1 30 1 disorganized myocardium 0.0231058488101901 0.0915948986698772 0.95877373961805 0.566666666666667 30.1 30 1 abnormal microglial cell physiology 0.0231058488101901 0.0915948986698772 0.95877373961805 0.566666666666667 30.1 30 1 abnormal fat pad morphology 0.0231058488101901 0.0915948986698772 0.95877373961805 0.566666666666667 30.1 30 1 blistering 0.0459490212009691 0.153641808776131 0.956321632867109 0.565217391304348 30.1 30 1 abnormal circulating insulin level 0.0459490212009691 0.153641808776131 0.956321632867109 0.565217391304348 30.1 30 1 abnormal nasal cavity morphology 0.0459490212009691 0.153641808776131 0.956321632867109 0.565217391304348 30.1 30 1 abnormal lens development 0.0459490212009691 0.153641808776131 0.956321632867109 0.565217391304348 30.1 30 1 abnormal chondrocyte physiology 0.0459490212009691 0.153641808776131 0.956321632867109 0.565217391304348 30.1 30 1 small lens 0.0111121804463022 0.0524010404932258 0.954435396904846 0.564102564102564 30.1 30 1 abnormal circulating hormone level 0.0111121804463022 0.0524010404932258 0.954435396904846 0.564102564102564 30.1 30 1 abnormal joint morphology 0.00287762541117563 0.0185683351758739 0.953646607320627 0.563636363636364 30.1 30 1 male infertility 1.51860329193521e-18 2.22207393452285e-16 0.9519341655195 0.562624254473161 30.1 30 1 increased body weight 4.50811623353709e-09 1.4852899511157e-07 0.951723932709094 0.5625 30.1 30 1 abnormal lymphatic vessel morphology 0.0215462919784471 0.08589166874421 0.951723932709094 0.5625 30.1 30 1 neonatal lethality 0.0215462919784471 0.08589166874421 0.951723932709094 0.5625 30.1 30 1 abnormal tympanic ring morphology 0.0946959760306414 0.254930996078161 0.951723932709094 0.5625 30.1 30 1 absent mandible 0.0946959760306414 0.254930996078161 0.951723932709094 0.5625 30.1 30 1 decreased mast cell number 0.0946959760306414 0.254930996078161 0.951723932709094 0.5625 30.1 30 1 delayed hair appearance 0.0946959760306414 0.254930996078161 0.951723932709094 0.5625 30.1 30 1 poor circulation 0.0946959760306414 0.254930996078161 0.951723932709094 0.5625 30.1 30 1 abnormal intestinal absorption 0.0946959760306414 0.254930996078161 0.951723932709094 0.5625 30.1 30 1 abnormal olfaction 0.0946959760306414 0.254930996078161 0.951723932709094 0.5625 30.1 30 1 white spotting 0.0946959760306414 0.254930996078161 0.951723932709094 0.5625 30.1 30 1 large intestinal inflammation 0.0946959760306414 0.254930996078161 0.951723932709094 0.5625 30.1 30 1 increased thymus weight 0.0946959760306414 0.254930996078161 0.951723932709094 0.5625 30.1 30 1 abnormal intestinal lipid absorption 0.0946959760306414 0.254930996078161 0.951723932709094 0.5625 30.1 30 1 abnormal Langerhans cell physiology 0.0946959760306414 0.254930996078161 0.951723932709094 0.5625 30.1 30 1 decreased circulating triiodothyronine level 0.0946959760306414 0.254930996078161 0.951723932709094 0.5625 30.1 30 1 embryonic lethality between somite formation and embryo turning, incomplete penetrance 0.0946959760306414 0.254930996078161 0.951723932709094 0.5625 30.1 30 1 decreased adipocyte glucose uptake 0.0946959760306414 0.254930996078161 0.951723932709094 0.5625 30.1 30 1 abnormal retina morphology 1.48620265255972e-08 4.40110606933607e-07 0.950716817436386 0.561904761904762 30.1 30 1 increased macrophage cell number 0.00270133734982473 0.0174988975460651 0.949868720364632 0.56140350877193 30.1 30 1 increased T cell proliferation 5.19447215834711e-05 0.000606656521371272 0.948759060644579 0.560747663551402 30.1 30 1 abnormal B cell differentiation 0.000187032947751521 0.00181381854788268 0.948237764457412 0.56043956043956 30.1 30 1 testicular atrophy 0.00510034813575069 0.029747048036764 0.94749404856372 0.56 30.1 30 1 abnormal inner ear vestibule morphology 0.0425835410354552 0.14333769732841 0.94749404856372 0.56 30.1 30 1 mandible hypoplasia 0.0425835410354552 0.14333769732841 0.94749404856372 0.56 30.1 30 1 increased pre-B cell number 0.0425835410354552 0.14333769732841 0.94749404856372 0.56 30.1 30 1 decreased placenta weight 0.0425835410354552 0.14333769732841 0.94749404856372 0.56 30.1 30 1 abnormal vertebrae development 0.0425835410354552 0.14333769732841 0.94749404856372 0.56 30.1 30 1 abnormal energy expenditure 0.0425835410354552 0.14333769732841 0.94749404856372 0.56 30.1 30 1 decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 0.0425835410354552 0.14333769732841 0.94749404856372 0.56 30.1 30 1 decreased T cell number 9.76067165674817e-07 1.83242798084235e-05 0.945812603934503 0.559006211180124 30.1 30 1 abnormal retinal photoreceptor morphology 0.020070218897972 0.0803293153800568 0.94550351484825 0.558823529411765 30.1 30 1 abnormal bone remodeling 0.020070218897972 0.0803293153800568 0.94550351484825 0.558823529411765 30.1 30 1 increased susceptibility to weight gain 0.020070218897972 0.0803293153800568 0.94550351484825 0.558823529411765 30.1 30 1 increased neutrophil cell number 3.43938594633463e-06 5.64717659505438e-05 0.945160319380066 0.558620689655172 30.1 30 1 impaired macrophage phagocytosis 0.00970798819493281 0.0479127726023391 0.944346227804372 0.558139534883721 30.1 30 1 abnormal hair growth 0.00477415228848072 0.0283060006847858 0.943589540121837 0.557692307692308 30.1 30 1 increased bone mineral density 4.33432839595646e-05 0.000522113408471752 0.943301597021403 0.557522123893805 30.1 30 1 hyperglycemia 0.000305289719828252 0.00282833585874405 0.942110559651426 0.556818181818182 30.1 30 1 cochlear outer hair cell degeneration 0.0011172187678272 0.00837072796677756 0.9399742545275 0.555555555555556 30.1 30 1 reduced long term depression 0.0186791468391105 0.0783471117065591 0.9399742545275 0.555555555555556 30.1 30 1 renal hypoplasia 0.0186791468391105 0.0783471117065591 0.9399742545275 0.555555555555556 30.1 30 1 abnormal brain commissure morphology 0.0394313516640482 0.133631454038583 0.9399742545275 0.555555555555556 30.1 30 1 abnormal heart shape 0.0867866085457485 0.236065269281082 0.9399742545275 0.555555555555556 30.1 30 1 underdeveloped hair follicles 0.0867866085457485 0.236065269281082 0.9399742545275 0.555555555555556 30.1 30 1 delayed kidney development 0.0867866085457485 0.236065269281082 0.9399742545275 0.555555555555556 30.1 30 1 absent spleen 0.0867866085457485 0.236065269281082 0.9399742545275 0.555555555555556 30.1 30 1 abnormal iron level 0.0867866085457485 0.236065269281082 0.9399742545275 0.555555555555556 30.1 30 1 eye inflammation 0.0867866085457485 0.236065269281082 0.9399742545275 0.555555555555556 30.1 30 1 abnormal thymus cortex morphology 0.0867866085457485 0.236065269281082 0.9399742545275 0.555555555555556 30.1 30 1 abnormal white adipose tissue morphology 0.0867866085457485 0.236065269281082 0.9399742545275 0.555555555555556 30.1 30 1 abnormal metacarpal bone morphology 0.0867866085457485 0.236065269281082 0.9399742545275 0.555555555555556 30.1 30 1 decreased activity of thyroid 0.0867866085457485 0.236065269281082 0.9399742545275 0.555555555555556 30.1 30 1 absent ureter 0.0867866085457485 0.236065269281082 0.9399742545275 0.555555555555556 30.1 30 1 atrioventricular block 0.0867866085457485 0.236065269281082 0.9399742545275 0.555555555555556 30.1 30 1 impaired leukocyte tethering or rolling 0.0867866085457485 0.236065269281082 0.9399742545275 0.555555555555556 30.1 30 1 renal tubular acidosis 0.209943763199441 0.419634480481005 0.9399742545275 0.555555555555556 30.1 30 1 abnormal urinary bladder urothelium morphology 0.209943763199441 0.419634480481005 0.9399742545275 0.555555555555556 30.1 30 1 absent parathyroid glands 0.209943763199441 0.419634480481005 0.9399742545275 0.555555555555556 30.1 30 1 absent enteric neurons 0.209943763199441 0.419634480481005 0.9399742545275 0.555555555555556 30.1 30 1 wavy vibrissae 0.209943763199441 0.419634480481005 0.9399742545275 0.555555555555556 30.1 30 1 abnormal kindling response 0.209943763199441 0.419634480481005 0.9399742545275 0.555555555555556 30.1 30 1 abnormal ion homeostasis 0.209943763199441 0.419634480481005 0.9399742545275 0.555555555555556 30.1 30 1 abnormal vomeronasal organ morphology 0.209943763199441 0.419634480481005 0.9399742545275 0.555555555555556 30.1 30 1 abnormal thymus lobule morphology 0.209943763199441 0.419634480481005 0.9399742545275 0.555555555555556 30.1 30 1 abnormal postural reflex 0.209943763199441 0.419634480481005 0.9399742545275 0.555555555555556 30.1 30 1 absent posterior semicircular canal 0.209943763199441 0.419634480481005 0.9399742545275 0.555555555555556 30.1 30 1 priapism 0.209943763199441 0.419634480481005 0.9399742545275 0.555555555555556 30.1 30 1 decreased muscle weight 0.209943763199441 0.419634480481005 0.9399742545275 0.555555555555556 30.1 30 1 small scapula 0.209943763199441 0.419634480481005 0.9399742545275 0.555555555555556 30.1 30 1 short frontal bone 0.209943763199441 0.419634480481005 0.9399742545275 0.555555555555556 30.1 30 1 increased neuronal precursor cell number 0.209943763199441 0.419634480481005 0.9399742545275 0.555555555555556 30.1 30 1 decreased susceptibility to atherosclerosis 0.209943763199441 0.419634480481005 0.9399742545275 0.555555555555556 30.1 30 1 abnormal leukopoiesis 0.209943763199441 0.419634480481005 0.9399742545275 0.555555555555556 30.1 30 1 absent cervical lymph nodes 0.209943763199441 0.419634480481005 0.9399742545275 0.555555555555556 30.1 30 1 eye opacity 0.209943763199441 0.419634480481005 0.9399742545275 0.555555555555556 30.1 30 1 abnormal hyoid bone lesser horn morphology 0.209943763199441 0.419634480481005 0.9399742545275 0.555555555555556 30.1 30 1 abnormal hippocampus granule cell morphology 0.209943763199441 0.419634480481005 0.9399742545275 0.555555555555556 30.1 30 1 retropulsion 0.209943763199441 0.419634480481005 0.9399742545275 0.555555555555556 30.1 30 1 abnormal heart left ventricle pressure 0.209943763199441 0.419634480481005 0.9399742545275 0.555555555555556 30.1 30 1 decreased effector memory CD4-positive, alpha-beta T cell number 0.209943763199441 0.419634480481005 0.9399742545275 0.555555555555556 30.1 30 1 abnormal ureteric bud invasion 0.209943763199441 0.419634480481005 0.9399742545275 0.555555555555556 30.1 30 1 increased core body temperature 0.209943763199441 0.419634480481005 0.9399742545275 0.555555555555556 30.1 30 1 increased myeloid cell number 0.209943763199441 0.419634480481005 0.9399742545275 0.555555555555556 30.1 30 1 abnormal coronary sinus connection 0.209943763199441 0.419634480481005 0.9399742545275 0.555555555555556 30.1 30 1 decreased bone mineral density of femur 0.209943763199441 0.419634480481005 0.9399742545275 0.555555555555556 30.1 30 1 increased bone mineralization 0.209943763199441 0.419634480481005 0.9399742545275 0.555555555555556 30.1 30 1 enhanced leukocyte tethering or rolling 0.209943763199441 0.419634480481005 0.9399742545275 0.555555555555556 30.1 30 1 increased endoplasmic reticulum stress 0.209943763199441 0.419634480481005 0.9399742545275 0.555555555555556 30.1 30 1 abnormal autopod morphology 0.0090624742709944 0.045312371354972 0.9399742545275 0.555555555555556 30.1 30 1 abnormal ovarian follicle morphology 0.0090624742709944 0.045312371354972 0.9399742545275 0.555555555555556 30.1 30 1 decreased litter size 2.64423968011478e-10 1.0695197080139e-08 0.939305233705772 0.555160142348754 30.1 30 1 abnormal seminiferous tubule morphology 4.92329469703536e-06 7.80044303113086e-05 0.938686618562394 0.554794520547945 30.1 30 1 increased sensitivity to xenobiotic induced morbidity/mortality 7.02329999853911e-05 0.00079592067181622 0.938265210428359 0.554545454545455 30.1 30 1 small testis 4.50308864932268e-10 1.73665628142483e-08 0.937930832235049 0.554347826086957 30.1 30 1 reduced long term potentiation 6.596358983434e-05 0.000757895749251366 0.936617203618473 0.553571428571429 30.1 30 1 circling 0.000496491188222811 0.00437951003795831 0.9355508462709 0.552941176470588 30.1 30 1 abnormal spermiogenesis 0.00390008275984583 0.0235758344231264 0.933491673461793 0.551724137931034 30.1 30 1 focal hair loss 0.0364911889232949 0.124601005417565 0.933491673461793 0.551724137931034 30.1 30 1 abnormal retinal pigmentation 0.000465299629568227 0.00413368867339631 0.933491673461793 0.551724137931034 30.1 30 1 lung inflammation 1.44305110212757e-05 0.00019886923083337 0.933062679126563 0.551470588235294 30.1 30 1 abnormal dendritic cell physiology 0.000113431905604919 0.00120882495337378 0.932946409633837 0.551401869158878 30.1 30 1 increased urine protein level 0.000918363371945502 0.00712770323779856 0.932743683338827 0.551282051282051 30.1 30 1 improved glucose tolerance 2.29575507044077e-07 5.03144558389551e-06 0.932300995306867 0.551020408163265 30.1 30 1 increased T cell derived lymphoma incidence 0.00788224783152349 0.0403853583540982 0.932300995306867 0.551020408163265 30.1 30 1 abnormal coat appearance 0.00182247648530785 0.0126808678523169 0.931800565357696 0.550724637681159 30.1 30 1 decreased heart rate 0.000208040001740209 0.00201361674836097 0.930574511982225 0.55 30.1 30 1 abnormal pancreatic beta cell morphology 0.0161483019493814 0.0714113797317088 0.930574511982225 0.55 30.1 30 1 abnormal fibula morphology 0.0795500180094791 0.218290865745813 0.930574511982225 0.55 30.1 30 1 decreased skin tensile strength 0.0795500180094791 0.218290865745813 0.930574511982225 0.55 30.1 30 1 abnormal heart right ventricle morphology 0.0795500180094791 0.218290865745813 0.930574511982225 0.55 30.1 30 1 abnormal incus morphology 0.0795500180094791 0.218290865745813 0.930574511982225 0.55 30.1 30 1 increased urine calcium level 0.0795500180094791 0.218290865745813 0.930574511982225 0.55 30.1 30 1 hyperactivity 1.75332835723675e-12 9.80090851376722e-11 0.930346485882744 0.549865229110512 30.1 30 1 abnormal nose morphology 0.0337567788523933 0.12101133538197 0.927845554469081 0.548387096774194 30.1 30 1 decreased neuronal precursor cell number 0.0337567788523933 0.12101133538197 0.927845554469081 0.548387096774194 30.1 30 1 abnormal CD8-positive, alpha beta T cell morphology 0.0337567788523933 0.12101133538197 0.927845554469081 0.548387096774194 30.1 30 1 decreased double-negative T cell number 0.0337567788523933 0.12101133538197 0.927845554469081 0.548387096774194 30.1 30 1 abnormal T cell proliferation 0.0337567788523933 0.12101133538197 0.927845554469081 0.548387096774194 30.1 30 1 abnormal intestine physiology 0.0337567788523933 0.12101133538197 0.927845554469081 0.548387096774194 30.1 30 1 abnormal spleen white pulp morphology 0.0150036740576609 0.0682296877850666 0.926546050891393 0.547619047619048 30.1 30 1 decreased startle reflex 8.20277638830656e-05 0.000914995796677694 0.925513112150154 0.547008547008547 30.1 30 1 decreased eosinophil cell number 0.00317196198912722 0.0200264816424664 0.925287156800508 0.546875 30.1 30 1 abnormal skin morphology 0.00295863996633724 0.0189436728861361 0.922883813536091 0.545454545454545 30.1 30 1 absent vibrissae 0.0312189920726199 0.116602466637601 0.922883813536091 0.545454545454545 30.1 30 1 abnormal T cell subpopulation ratio 0.0312189920726199 0.116602466637601 0.922883813536091 0.545454545454545 30.1 30 1 head tossing 0.0312189920726199 0.116602466637601 0.922883813536091 0.545454545454545 30.1 30 1 cardiovascular system phenotype 0.0312189920726199 0.116602466637601 0.922883813536091 0.545454545454545 30.1 30 1 myeloid hyperplasia 0.0312189920726199 0.116602466637601 0.922883813536091 0.545454545454545 30.1 30 1 abnormal long bone epiphysis morphology 0.0729406653814019 0.201487956842018 0.922883813536091 0.545454545454545 30.1 30 1 intestinal ulcer 0.0729406653814019 0.201487956842018 0.922883813536091 0.545454545454545 30.1 30 1 intracerebral hemorrhage 0.0729406653814019 0.201487956842018 0.922883813536091 0.545454545454545 30.1 30 1 abnormal oogenesis 0.0729406653814019 0.201487956842018 0.922883813536091 0.545454545454545 30.1 30 1 abnormal female reproductive system physiology 0.0729406653814019 0.201487956842018 0.922883813536091 0.545454545454545 30.1 30 1 abnormal retinal outer plexiform layer morphology 0.0729406653814019 0.201487956842018 0.922883813536091 0.545454545454545 30.1 30 1 abnormal limb posture 0.0729406653814019 0.201487956842018 0.922883813536091 0.545454545454545 30.1 30 1 abnormal temporal bone morphology 0.0729406653814019 0.201487956842018 0.922883813536091 0.545454545454545 30.1 30 1 abnormal thrombopoiesis 0.187463451905755 0.383167901902682 0.922883813536091 0.545454545454545 30.1 30 1 increased mast cell number 0.187463451905755 0.383167901902682 0.922883813536091 0.545454545454545 30.1 30 1 abnormal glossopharyngeal ganglion morphology 0.187463451905755 0.383167901902682 0.922883813536091 0.545454545454545 30.1 30 1 abnormal vestibular ganglion morphology 0.187463451905755 0.383167901902682 0.922883813536091 0.545454545454545 30.1 30 1 decreased post-tetanic potentiation 0.187463451905755 0.383167901902682 0.922883813536091 0.545454545454545 30.1 30 1 abnormal frequency of paradoxical sleep 0.187463451905755 0.383167901902682 0.922883813536091 0.545454545454545 30.1 30 1 abnormal lymph circulation 0.187463451905755 0.383167901902682 0.922883813536091 0.545454545454545 30.1 30 1 abnormal coronal suture morphology 0.187463451905755 0.383167901902682 0.922883813536091 0.545454545454545 30.1 30 1 increased motor neuron number 0.187463451905755 0.383167901902682 0.922883813536091 0.545454545454545 30.1 30 1 abnormal Bruch membrane morphology 0.187463451905755 0.383167901902682 0.922883813536091 0.545454545454545 30.1 30 1 increased circulating triiodothyronine level 0.187463451905755 0.383167901902682 0.922883813536091 0.545454545454545 30.1 30 1 abnormal platelet aggregation 0.187463451905755 0.383167901902682 0.922883813536091 0.545454545454545 30.1 30 1 aberrant origin of the right subclavian artery 0.187463451905755 0.383167901902682 0.922883813536091 0.545454545454545 30.1 30 1 chylous ascites 0.187463451905755 0.383167901902682 0.922883813536091 0.545454545454545 30.1 30 1 decreased colon length 0.187463451905755 0.383167901902682 0.922883813536091 0.545454545454545 30.1 30 1 decreased susceptibility to injury 0.00275882821196704 0.0178349463225459 0.920621843404875 0.544117647058823 30.1 30 1 abnormal sleep pattern 0.0129390048315951 0.0592739862220861 0.919540031602989 0.543478260869565 30.1 30 1 increased B cell proliferation 0.00551937532094715 0.03106209527343 0.917669780691254 0.542372881355932 30.1 30 1 abnormal neuromuscular synapse morphology 0.002396897589638 0.0159632737730242 0.916474898164313 0.541666666666667 30.1 30 1 abnormal lymph node morphology 0.0120112577520168 0.0563735918078149 0.916474898164313 0.541666666666667 30.1 30 1 decreased metastatic potential 0.0669083664745811 0.195690254680212 0.916474898164313 0.541666666666667 30.1 30 1 abnormal tumor morphology 0.0669083664745811 0.195690254680212 0.916474898164313 0.541666666666667 30.1 30 1 increased circulating total protein level 0.0669083664745811 0.195690254680212 0.916474898164313 0.541666666666667 30.1 30 1 abnormal NK cell physiology 0.0051352778458819 0.0299156993949209 0.915319192113664 0.540983606557377 30.1 30 1 azoospermia 9.86978497953871e-06 0.000142325160212189 0.91514474591734 0.540880503144654 30.1 30 1 decreased T cell proliferation 2.03785743577109e-05 0.000268952812630153 0.914569544945676 0.540540540540541 30.1 30 1 increased brown adipose tissue amount 0.0266900707117539 0.104966878886147 0.914569544945676 0.540540540540541 30.1 30 1 increased white adipose tissue amount 0.0266900707117539 0.104966878886147 0.914569544945676 0.540540540540541 30.1 30 1 abnormal vocalization 0.0266900707117539 0.104966878886147 0.914569544945676 0.540540540540541 30.1 30 1 abnormal axon extension 0.0111479561700393 0.0525199639639635 0.91365497540073 0.54 30.1 30 1 increased circulating glucose level 3.68337056653692e-05 0.000454708897481914 0.911975021413915 0.539007092198582 30.1 30 1 increased vascular permeability 0.0246762037458682 0.0976643704341242 0.911051969772808 0.538461538461538 30.1 30 1 increased susceptibility to otitis media 0.061403247335368 0.188336100797445 0.911051969772808 0.538461538461538 30.1 30 1 uterus hypoplasia 0.16821714741665 0.348119928618068 0.911051969772808 0.538461538461538 30.1 30 1 tight skin 0.16821714741665 0.348119928618068 0.911051969772808 0.538461538461538 30.1 30 1 increased pituitary adenoma incidence 0.16821714741665 0.348119928618068 0.911051969772808 0.538461538461538 30.1 30 1 abnormal bile duct development 0.16821714741665 0.348119928618068 0.911051969772808 0.538461538461538 30.1 30 1 abnormal telomere length 0.16821714741665 0.348119928618068 0.911051969772808 0.538461538461538 30.1 30 1 small interparietal bone 0.16821714741665 0.348119928618068 0.911051969772808 0.538461538461538 30.1 30 1 abnormal exocrine pancreas morphology 0.16821714741665 0.348119928618068 0.911051969772808 0.538461538461538 30.1 30 1 abnormal vertebral arch development 0.16821714741665 0.348119928618068 0.911051969772808 0.538461538461538 30.1 30 1 abnormal hair follicle inner root sheath morphology 0.16821714741665 0.348119928618068 0.911051969772808 0.538461538461538 30.1 30 1 small ovary 0.000854585978169393 0.00680250438622837 0.911051969772808 0.538461538461538 30.1 30 1 decreased monocyte cell number 0.00444285891966317 0.0265344815430063 0.911051969772808 0.538461538461538 30.1 30 1 increased total body fat amount 6.65708661654754e-05 0.000763110735422212 0.909109428259433 0.537313432835821 30.1 30 1 polyphagia 0.00959909026008443 0.0478032773212413 0.908641779376583 0.537037037037037 30.1 30 1 scaly skin 0.0228143596758414 0.0908011515098486 0.907877572665585 0.536585365853659 30.1 30 1 short ulna 0.0228143596758414 0.0908011515098486 0.907877572665585 0.536585365853659 30.1 30 1 increased lymphocyte cell number 0.00384148489591677 0.0232781819210547 0.907279497848283 0.536231884057971 30.1 30 1 abnormal circulating cholesterol level 0.0563779841393194 0.174754187596956 0.906403745437232 0.535714285714286 30.1 30 1 myoclonus 0.0563779841393194 0.174754187596956 0.906403745437232 0.535714285714286 30.1 30 1 abnormal jaw morphology 0.0563779841393194 0.174754187596956 0.906403745437232 0.535714285714286 30.1 30 1 failure of blastocyst to hatch from the zona pellucida 0.0563779841393194 0.174754187596956 0.906403745437232 0.535714285714286 30.1 30 1 abnormal hormone level 0.0563779841393194 0.174754187596956 0.906403745437232 0.535714285714286 30.1 30 1 corneal vascularization 0.0563779841393194 0.174754187596956 0.906403745437232 0.535714285714286 30.1 30 1 abnormal male reproductive system morphology 0.0210937127997981 0.084222488907701 0.904998468312523 0.534883720930233 30.1 30 1 thrombocytosis 0.00826242162503212 0.0422896580087806 0.904320058666112 0.53448275862069 30.1 30 1 increased T cell number 0.00135590200205485 0.0100231983064233 0.903657067420756 0.534090909090909 30.1 30 1 abnormal humoral immune response 0.000521694970056278 0.00456139275224953 0.9023752843464 0.533333333333333 30.1 30 1 increased metastatic potential 0.0517887204811288 0.162043323517997 0.9023752843464 0.533333333333333 30.1 30 1 abnormal pain threshold 0.0517887204811288 0.162043323517997 0.9023752843464 0.533333333333333 30.1 30 1 abnormal synaptic transmission 0.0517887204811288 0.162043323517997 0.9023752843464 0.533333333333333 30.1 30 1 macrocytosis 0.151525752324501 0.316208312841607 0.9023752843464 0.533333333333333 30.1 30 1 abnormal prostate gland morphology 0.151525752324501 0.316208312841607 0.9023752843464 0.533333333333333 30.1 30 1 hyperpigmentation 0.151525752324501 0.316208312841607 0.9023752843464 0.533333333333333 30.1 30 1 abnormal epidermis stratum spinosum morphology 0.151525752324501 0.316208312841607 0.9023752843464 0.533333333333333 30.1 30 1 abnormal pup retrieval 0.151525752324501 0.316208312841607 0.9023752843464 0.533333333333333 30.1 30 1 altered righting response 0.151525752324501 0.316208312841607 0.9023752843464 0.533333333333333 30.1 30 1 dilated ureter 0.151525752324501 0.316208312841607 0.9023752843464 0.533333333333333 30.1 30 1 abnormal rostral migratory stream morphology 0.151525752324501 0.316208312841607 0.9023752843464 0.533333333333333 30.1 30 1 ostium primum atrial septal defect 0.151525752324501 0.316208312841607 0.9023752843464 0.533333333333333 30.1 30 1 abnormal cytokine secretion 3.33948133291745e-05 0.000420605560285173 0.900910389404279 0.532467532467532 30.1 30 1 abnormal innervation 0.0180353706196398 0.0783045538073052 0.899975350079521 0.531914893617021 30.1 30 1 abnormal T-helper 1 physiology 0.0180353706196398 0.0783045538073052 0.899975350079521 0.531914893617021 30.1 30 1 impaired synaptic plasticity 0.0437613618940989 0.147003899678016 0.8957401719615 0.529411764705882 30.1 30 1 distended urinary bladder 0.136911040478256 0.309826184060518 0.8957401719615 0.529411764705882 30.1 30 1 increased incidence of corneal inflammation 0.136911040478256 0.309826184060518 0.8957401719615 0.529411764705882 30.1 30 1 abnormal glutamate-mediated receptor currents 0.136911040478256 0.309826184060518 0.8957401719615 0.529411764705882 30.1 30 1 nephrocalcinosis 0.136911040478256 0.309826184060518 0.8957401719615 0.529411764705882 30.1 30 1 aminoaciduria 0.136911040478256 0.309826184060518 0.8957401719615 0.529411764705882 30.1 30 1 abnormal involuntary movement 0.136911040478256 0.309826184060518 0.8957401719615 0.529411764705882 30.1 30 1 abnormal melanosome morphology 0.136911040478256 0.309826184060518 0.8957401719615 0.529411764705882 30.1 30 1 pancytopenia 0.136911040478256 0.309826184060518 0.8957401719615 0.529411764705882 30.1 30 1 decreased cardiac muscle contractility 0.000762179505495045 0.00619582196051936 0.894783184598293 0.528846153846154 30.1 30 1 abnormal limb bone morphology 0.0402538260250074 0.136233186717287 0.892975541801125 0.527777777777778 30.1 30 1 short radius 0.0402538260250074 0.136233186717287 0.892975541801125 0.527777777777778 30.1 30 1 increased thermal nociceptive threshold 0.00171680861147895 0.0122365656763722 0.892459072430505 0.527472527472527 30.1 30 1 abnormal locomotor activation 0.00171680861147895 0.0122365656763722 0.892459072430505 0.527472527472527 30.1 30 1 abnormal learning/memory/conditioning 0.0131993834599692 0.0603556366850613 0.892121019751555 0.527272727272727 30.1 30 1 abnormal T-helper 2 physiology 0.0131993834599692 0.0603556366850613 0.892121019751555 0.527272727272727 30.1 30 1 impaired righting response 0.00148231229161574 0.0107656987602749 0.890501925341842 0.526315789473684 30.1 30 1 abnormal reproductive system physiology 0.0370429282889742 0.125708436724179 0.890501925341842 0.526315789473684 30.1 30 1 flaky skin 0.124019957883687 0.309826184060518 0.890501925341842 0.526315789473684 30.1 30 1 abnormal ear morphology 0.124019957883687 0.309826184060518 0.890501925341842 0.526315789473684 30.1 30 1 abnormal optic vesicle formation 0.124019957883687 0.309826184060518 0.890501925341842 0.526315789473684 30.1 30 1 oliguria 0.124019957883687 0.309826184060518 0.890501925341842 0.526315789473684 30.1 30 1 increased circulating VLDL cholesterol level 0.124019957883687 0.309826184060518 0.890501925341842 0.526315789473684 30.1 30 1 decreased circulating magnesium level 0.124019957883687 0.309826184060518 0.890501925341842 0.526315789473684 30.1 30 1 shortened RR interval 0.124019957883687 0.309826184060518 0.890501925341842 0.526315789473684 30.1 30 1 increased rib number 0.00389935145031462 0.0235758344231264 0.889360256206788 0.525641025641026 30.1 30 1 increased susceptibility to weight loss 0.0341017794156695 0.12101133538197 0.888275670528487 0.525 30.1 30 1 abnormal T cell differentiation 0.00118917360894918 0.00886977317019813 0.887856870118054 0.524752475247525 30.1 30 1 abnormal excitatory postsynaptic potential 0.00335629605972948 0.0204126808033669 0.88724399146864 0.524390243902439 30.1 30 1 abnormal response/metabolism to endogenous compounds 0.00335629605972948 0.0204126808033669 0.88724399146864 0.524390243902439 30.1 30 1 abnormal optic nerve morphology 0.0314061138558399 0.117213365666019 0.886261439983071 0.523809523809524 30.1 30 1 trunk curl 0.112582432054785 0.295806960315824 0.886261439983071 0.523809523809524 30.1 30 1 abnormal associative learning 0.112582432054785 0.295806960315824 0.886261439983071 0.523809523809524 30.1 30 1 dry skin 0.112582432054785 0.295806960315824 0.886261439983071 0.523809523809524 30.1 30 1 increased acute inflammation 0.112582432054785 0.295806960315824 0.886261439983071 0.523809523809524 30.1 30 1 increased bone ossification 0.112582432054785 0.295806960315824 0.886261439983071 0.523809523809524 30.1 30 1 decreased vocalization 0.112582432054785 0.295806960315824 0.886261439983071 0.523809523809524 30.1 30 1 abnormal circadian rhythm 0.0289340253605046 0.110404693021963 0.884430321305421 0.522727272727273 30.1 30 1 lethality, incomplete penetrance 0.0289340253605046 0.110404693021963 0.884430321305421 0.522727272727273 30.1 30 1 decreased IgG level 0.000823705367748828 0.00665249059180263 0.884083893447487 0.522522522522523 30.1 30 1 abnormal immune system morphology 0.0266657245141661 0.104966878886147 0.88275843033887 0.521739130434783 30.1 30 1 bidirectional circling 0.10238609539642 0.274445487390726 0.88275843033887 0.521739130434783 30.1 30 1 failure of embryo implantation 0.10238609539642 0.274445487390726 0.88275843033887 0.521739130434783 30.1 30 1 pancreas inflammation 0.10238609539642 0.274445487390726 0.88275843033887 0.521739130434783 30.1 30 1 abnormal crista ampullaris morphology 0.10238609539642 0.274445487390726 0.88275843033887 0.521739130434783 30.1 30 1 abnormal ulna morphology 0.10238609539642 0.274445487390726 0.88275843033887 0.521739130434783 30.1 30 1 abnormal corneal stroma morphology 0.10238609539642 0.274445487390726 0.88275843033887 0.521739130434783 30.1 30 1 decreased effector memory CD8-positive, alpha-beta T cell number 0.10238609539642 0.274445487390726 0.88275843033887 0.521739130434783 30.1 30 1 abnormal CD4-positive, alpha-beta T cell physiology 0.00710813026547519 0.0373026878383323 0.88172232889481 0.52112676056338 30.1 30 1 abnormal kidney physiology 0.0245833193887952 0.0973742149357135 0.881225863619531 0.520833333333333 30.1 30 1 decreased anxiety-related response 0.000530322330160253 0.00458490664898153 0.880366131069659 0.520325203252033 30.1 30 1 obese 0.00564622744517397 0.031280603050936 0.878936965272468 0.519480519480519 30.1 30 1 absent corpus luteum 0.0209129559723268 0.083567836114318 0.878514399423779 0.519230769230769 30.1 30 1 decreased IgA level 0.0209129559723268 0.083567836114318 0.878514399423779 0.519230769230769 30.1 30 1 decreased food intake 0.00523018739399996 0.0299813323747206 0.878102531444677 0.518987341772152 30.1 30 1 increased exploration in new environment 0.00484529406890664 0.028438277051809 0.877309304225667 0.518518518518518 30.1 30 1 abnormal cochlea morphology 0.0192970328940989 0.078528708111807 0.877309304225667 0.518518518518518 30.1 30 1 abnormal neuronal precursor proliferation 0.0192970328940989 0.078528708111807 0.877309304225667 0.518518518518518 30.1 30 1 thin epidermis 0.0850652888275588 0.233296478454854 0.877309304225667 0.518518518518518 30.1 30 1 decreased granulocyte number 0.0776852647279173 0.214118665939828 0.875148443870431 0.517241379310345 30.1 30 1 increased susceptibility to induced arthritis 0.0776852647279173 0.214118665939828 0.875148443870431 0.517241379310345 30.1 30 1 polychromatophilia 0.0776852647279173 0.214118665939828 0.875148443870431 0.517241379310345 30.1 30 1 increased eosinophil cell number 0.0140252662620066 0.0640144033518193 0.873266404206194 0.516129032258065 30.1 30 1 abnormal cranial ganglia morphology 0.0710227915517802 0.197671576717944 0.873266404206194 0.516129032258065 30.1 30 1 abnormal ovarian folliculogenesis 0.0649951903737517 0.195690254680212 0.871612490561864 0.515151515151515 30.1 30 1 abnormal epidermis stratum basale morphology 0.0649951903737517 0.195690254680212 0.871612490561864 0.515151515151515 30.1 30 1 dilated heart atrium 0.0649951903737517 0.195690254680212 0.871612490561864 0.515151515151515 30.1 30 1 single kidney 0.0649951903737517 0.195690254680212 0.871612490561864 0.515151515151515 30.1 30 1 increased susceptibility to bacterial infection induced morbidity/mortality 0.00945923055704988 0.0471539799812857 0.869476185437938 0.513888888888889 30.1 30 1 increased insulin secretion 0.0545711233001087 0.1698944545795 0.868841067698392 0.513513513513513 30.1 30 1 arrested B cell differentiation 0.0459535701424889 0.153641808776131 0.866610410271695 0.51219512195122 30.1 30 1 short humerus 0.0459535701424889 0.153641808776131 0.866610410271695 0.51219512195122 30.1 30 1 arrest of spermatogenesis 0.00593143508679666 0.0324630248149762 0.866119134528911 0.511904761904762 30.1 30 1 abnormal intestinal mucosa morphology 0.0422095816288363 0.142755043238246 0.865650708820675 0.511627906976744 30.1 30 1 abnormal suckling behavior 0.00508296778898015 0.0296804750588923 0.865203575190085 0.511363636363636 30.1 30 1 altered response to myocardial infarction 0.0387927324358064 0.131556812452718 0.8647763141653 0.511111111111111 30.1 30 1 increased anxiety-related response 0.000546595420138174 0.00468039968190605 0.864235321788594 0.510791366906475 30.1 30 1 increased fluid intake 0.0328171581439164 0.12101133538197 0.863241662321173 0.510204081632653 30.1 30 1 abnormal pancreatic islet morphology 0.0278129990488022 0.109296737968239 0.861938656038425 0.509433962264151 30.1 30 1 seizures 0.00188498168011733 0.0130974634896421 0.860818527830447 0.508771929824561 30.1 30 1 skin lesions 0.0185134638070126 0.0783471117065591 0.859405032710857 0.507936507936508 30.1 30 1 abnormal food intake 0.014556249423536 0.0662555726277141 0.858237362829457 0.507246376811594 30.1 30 1 increased startle reflex 0.00662793439523945 0.0360765575670856 0.855482186704803 0.50561797752809 30.1 30 1 abnormal phalanx morphology 0.0467593029846356 0.156230713464448 0.84597682907475 0.5 30.1 30 1 abnormal vision 0.0862290188534044 0.236065269281082 0.84597682907475 0.5 30.1 30 1 decreased osteoblast cell number 0.0862290188534044 0.236065269281082 0.84597682907475 0.5 30.1 30 1 abnormal malleus morphology 0.137863824318258 0.309826184060518 0.84597682907475 0.5 30.1 30 1 abnormal leukocyte cell number 0.125117274065234 0.309826184060518 0.84597682907475 0.5 30.1 30 1 abnormal stomach morphology 0.125117274065234 0.309826184060518 0.84597682907475 0.5 30.1 30 1 abnormal adrenal gland morphology 0.137863824318258 0.309826184060518 0.84597682907475 0.5 30.1 30 1 no spontaneous movement 0.125117274065234 0.309826184060518 0.84597682907475 0.5 30.1 30 1 apnea 0.137863824318258 0.309826184060518 0.84597682907475 0.5 30.1 30 1 small lymph nodes 0.137863824318258 0.309826184060518 0.84597682907475 0.5 30.1 30 1 abnormal impulse conducting system conduction 0.137863824318258 0.309826184060518 0.84597682907475 0.5 30.1 30 1 abnormal cellular extravasation 0.137863824318258 0.309826184060518 0.84597682907475 0.5 30.1 30 1 abnormal supraoccipital bone morphology 0.262312153492279 0.503667681830987 0.84597682907475 0.5 30.1 30 1 abnormal mineral level 0.262312153492279 0.503667681830987 0.84597682907475 0.5 30.1 30 1 decreased digestive secretion 0.262312153492279 0.503667681830987 0.84597682907475 0.5 30.1 30 1 abnormal enteric nervous system morphology 0.262312153492279 0.503667681830987 0.84597682907475 0.5 30.1 30 1 abnormal mating frequency 0.262312153492279 0.503667681830987 0.84597682907475 0.5 30.1 30 1 increased litter size 0.262312153492279 0.503667681830987 0.84597682907475 0.5 30.1 30 1 abnormal respiratory function 0.262312153492279 0.503667681830987 0.84597682907475 0.5 30.1 30 1 abnormal AMPA-mediated synaptic currents 0.262312153492279 0.503667681830987 0.84597682907475 0.5 30.1 30 1 increased circulating parathyroid hormone level 0.262312153492279 0.503667681830987 0.84597682907475 0.5 30.1 30 1 small thyroid gland 0.262312153492279 0.503667681830987 0.84597682907475 0.5 30.1 30 1 abnormal aorta elastic fiber morphology 0.262312153492279 0.503667681830987 0.84597682907475 0.5 30.1 30 1 dilated bile duct 0.262312153492279 0.503667681830987 0.84597682907475 0.5 30.1 30 1 increased fear-related response 0.262312153492279 0.503667681830987 0.84597682907475 0.5 30.1 30 1 increased hepatocyte proliferation 0.262312153492279 0.503667681830987 0.84597682907475 0.5 30.1 30 1 vestibular saccular macula degeneration 0.262312153492279 0.503667681830987 0.84597682907475 0.5 30.1 30 1 stria vascularis degeneration 0.262312153492279 0.503667681830987 0.84597682907475 0.5 30.1 30 1 abnormal cochlear outer hair cell physiology 0.262312153492279 0.503667681830987 0.84597682907475 0.5 30.1 30 1 abnormal palatine bone morphology 0.262312153492279 0.503667681830987 0.84597682907475 0.5 30.1 30 1 impaired behavioral response to cocaine 0.262312153492279 0.503667681830987 0.84597682907475 0.5 30.1 30 1 abnormal aorta elastic tissue morphology 0.262312153492279 0.503667681830987 0.84597682907475 0.5 30.1 30 1 abnormal respiratory motile cilium morphology 0.262312153492279 0.503667681830987 0.84597682907475 0.5 30.1 30 1 embryonic lethality between implantation and placentation, incomplete penetrance 0.262312153492279 0.503667681830987 0.84597682907475 0.5 30.1 30 1 abnormal posture 0.0126699518485738 0.0580949405038292 0.84597682907475 0.5 30.1 30 1 abnormal inflammatory response 0.0174248316881577 0.0768515404686035 0.84597682907475 0.5 30.1 30 1 abnormal female reproductive system morphology 0.0660192867267128 0.195690254680212 0.84597682907475 0.5 30.1 30 1 head bobbing 0.0660192867267128 0.195690254680212 0.84597682907475 0.5 30.1 30 1 abnormal skin pigmentation 0.0660192867267128 0.195690254680212 0.84597682907475 0.5 30.1 30 1 abnormal epidermis stratum granulosum morphology 0.0788094975172691 0.216856886144034 0.84597682907475 0.5 30.1 30 1 decreased susceptibility to parasitic infection 0.0944502524606941 0.254930996078161 0.84597682907475 0.5 30.1 30 1 abnormal serotonin level 0.0944502524606941 0.254930996078161 0.84597682907475 0.5 30.1 30 1 gastrointestinal hemorrhage 0.103581808974706 0.275571924946076 0.84597682907475 0.5 30.1 30 1 abnormal spleen germinal center morphology 0.113752593515798 0.298480565791716 0.84597682907475 0.5 30.1 30 1 decreased circulating progesterone level 0.113752593515798 0.298480565791716 0.84597682907475 0.5 30.1 30 1 testis hypoplasia 0.152224198728168 0.31700099986297 0.84597682907475 0.5 30.1 30 1 abnormal circulating lipid level 0.152224198728168 0.31700099986297 0.84597682907475 0.5 30.1 30 1 abnormal blood-brain barrier function 0.152224198728168 0.31700099986297 0.84597682907475 0.5 30.1 30 1 abnormal cerebral cortex pyramidal cell morphology 0.152224198728168 0.31700099986297 0.84597682907475 0.5 30.1 30 1 impaired humoral immune response 0.152224198728168 0.31700099986297 0.84597682907475 0.5 30.1 30 1 waved hair 0.168489897757895 0.348249788676995 0.84597682907475 0.5 30.1 30 1 abnormal hyoid bone morphology 0.168489897757895 0.348249788676995 0.84597682907475 0.5 30.1 30 1 decreased circulating VLDL cholesterol level 0.168489897757895 0.348249788676995 0.84597682907475 0.5 30.1 30 1 abnormal radius morphology 0.187035472410765 0.383167901902682 0.84597682907475 0.5 30.1 30 1 abnormal phrenic nerve morphology 0.187035472410765 0.383167901902682 0.84597682907475 0.5 30.1 30 1 abnormal Peyer's patch follicle morphology 0.187035472410765 0.383167901902682 0.84597682907475 0.5 30.1 30 1 abnormal neutrophil morphology 0.187035472410765 0.383167901902682 0.84597682907475 0.5 30.1 30 1 abnormal anterior eye segment morphology 0.187035472410765 0.383167901902682 0.84597682907475 0.5 30.1 30 1 abnormal eye anterior chamber morphology 0.187035472410765 0.383167901902682 0.84597682907475 0.5 30.1 30 1 increased susceptibility to autoimmune disorder 0.187035472410765 0.383167901902682 0.84597682907475 0.5 30.1 30 1 abnormal sperm axoneme morphology 0.187035472410765 0.383167901902682 0.84597682907475 0.5 30.1 30 1 decreased fluid intake 0.187035472410765 0.383167901902682 0.84597682907475 0.5 30.1 30 1 mixed cellular infiltration to dermis 0.20835552861836 0.419634480481005 0.84597682907475 0.5 30.1 30 1 abnormal meiosis 0.20835552861836 0.419634480481005 0.84597682907475 0.5 30.1 30 1 paternal imprinting 0.20835552861836 0.419634480481005 0.84597682907475 0.5 30.1 30 1 abnormal wound healing 0.20835552861836 0.419634480481005 0.84597682907475 0.5 30.1 30 1 abnormal level of surface class II molecules 0.20835552861836 0.419634480481005 0.84597682907475 0.5 30.1 30 1 sepsis 0.20835552861836 0.419634480481005 0.84597682907475 0.5 30.1 30 1 abnormal thoracic cage shape 0.20835552861836 0.419634480481005 0.84597682907475 0.5 30.1 30 1 decreased skeletal muscle weight 0.20835552861836 0.419634480481005 0.84597682907475 0.5 30.1 30 1 abnormal urinary bladder physiology 0.20835552861836 0.419634480481005 0.84597682907475 0.5 30.1 30 1 abnormal interparietal bone morphology 0.23312600149633 0.460688758795695 0.84597682907475 0.5 30.1 30 1 abnormal pinna reflex 0.23312600149633 0.460688758795695 0.84597682907475 0.5 30.1 30 1 extended life span 0.23312600149633 0.460688758795695 0.84597682907475 0.5 30.1 30 1 absent otoliths 0.23312600149633 0.460688758795695 0.84597682907475 0.5 30.1 30 1 abnormal imprinting 0.23312600149633 0.460688758795695 0.84597682907475 0.5 30.1 30 1 abnormal hair cuticle 0.23312600149633 0.460688758795695 0.84597682907475 0.5 30.1 30 1 enlarged stomach 0.23312600149633 0.460688758795695 0.84597682907475 0.5 30.1 30 1 abnormal positive T cell selection 0.23312600149633 0.460688758795695 0.84597682907475 0.5 30.1 30 1 increased B-1 B cell number 0.23312600149633 0.460688758795695 0.84597682907475 0.5 30.1 30 1 abnormal iris pigmentation 0.23312600149633 0.460688758795695 0.84597682907475 0.5 30.1 30 1 premature hair loss 0.23312600149633 0.460688758795695 0.84597682907475 0.5 30.1 30 1 sternebra fusion 0.23312600149633 0.460688758795695 0.84597682907475 0.5 30.1 30 1 abnormal renal reabsorbtion 0.23312600149633 0.460688758795695 0.84597682907475 0.5 30.1 30 1 increased lung compliance 0.23312600149633 0.460688758795695 0.84597682907475 0.5 30.1 30 1 pulmonary alveolar hemorrhage 0.23312600149633 0.460688758795695 0.84597682907475 0.5 30.1 30 1 decreased compact bone area 0.23312600149633 0.460688758795695 0.84597682907475 0.5 30.1 30 1 abnormal respiratory motile cilium physiology 0.23312600149633 0.460688758795695 0.84597682907475 0.5 30.1 30 1 decreased response to antigen 0.23312600149633 0.460688758795695 0.84597682907475 0.5 30.1 30 1 absent maxillary shelf 0.297374643613902 0.531063265826113 0.84597682907475 0.5 30.1 30 1 jaundice 0.297374643613902 0.531063265826113 0.84597682907475 0.5 30.1 30 1 small petrosal ganglion 0.297374643613902 0.531063265826113 0.84597682907475 0.5 30.1 30 1 enlarged testis 0.297374643613902 0.531063265826113 0.84597682907475 0.5 30.1 30 1 abnormal pituitary secretion 0.297374643613902 0.531063265826113 0.84597682907475 0.5 30.1 30 1 abnormal PNS synaptic transmission 0.297374643613902 0.531063265826113 0.84597682907475 0.5 30.1 30 1 abnormal bone healing 0.297374643613902 0.531063265826113 0.84597682907475 0.5 30.1 30 1 delayed dark adaptation 0.297374643613902 0.531063265826113 0.84597682907475 0.5 30.1 30 1 rickets 0.297374643613902 0.531063265826113 0.84597682907475 0.5 30.1 30 1 abnormal hypaxial muscle morphology 0.297374643613902 0.531063265826113 0.84597682907475 0.5 30.1 30 1 abnormal ear physiology 0.297374643613902 0.531063265826113 0.84597682907475 0.5 30.1 30 1 abnormal placental transport 0.297374643613902 0.531063265826113 0.84597682907475 0.5 30.1 30 1 abnormal utricular macula morphology 0.297374643613902 0.531063265826113 0.84597682907475 0.5 30.1 30 1 abnormal deltoid tuberosity morphology 0.297374643613902 0.531063265826113 0.84597682907475 0.5 30.1 30 1 decreased cochlear inner hair cell number 0.297374643613902 0.531063265826113 0.84597682907475 0.5 30.1 30 1 ascites 0.297374643613902 0.531063265826113 0.84597682907475 0.5 30.1 30 1 tachypnea 0.297374643613902 0.531063265826113 0.84597682907475 0.5 30.1 30 1 abnormal developmental vascular remodeling 0.297374643613902 0.531063265826113 0.84597682907475 0.5 30.1 30 1 crystalluria 0.297374643613902 0.531063265826113 0.84597682907475 0.5 30.1 30 1 abnormal sperm principal piece morphology 0.297374643613902 0.531063265826113 0.84597682907475 0.5 30.1 30 1 abnormal cerebellar granule cell migration 0.297374643613902 0.531063265826113 0.84597682907475 0.5 30.1 30 1 umbilical hernia 0.297374643613902 0.531063265826113 0.84597682907475 0.5 30.1 30 1 common ventricle 0.297374643613902 0.531063265826113 0.84597682907475 0.5 30.1 30 1 decreased insulin secretion 0.00854952653412962 0.0436245071869691 0.84597682907475 0.5 30.1 30 1 increased double-negative T cell number 0.0363520324684708 0.124397936526207 0.832108356466967 0.491803278688525 30.1 30 1 impaired natural killer cell mediated cytotoxicity 0.0429121407717784 0.144346112467612 0.831135130319053 0.491228070175439 30.1 30 1 abnormal cartilage development 0.0714517865993392 0.198255793826945 0.8271773439842 0.488888888888889 30.1 30 1 abnormal nervous system electrophysiology 0.0189061706589965 0.0783471117065591 0.825834523620589 0.488095238095238 30.1 30 1 abnormal breathing pattern 0.101772167828263 0.273832631122558 0.823112590451108 0.486486486486487 30.1 30 1 dehydration 0.0331285046304896 0.12101133538197 0.821806062529757 0.485714285714286 30.1 30 1 abnormal immune system physiology 0.00675209438290371 0.0367122071638754 0.818687253943307 0.483870967741935 30.1 30 1 abnormal retinal photoreceptor layer morphology 0.134105887808699 0.309826184060518 0.818687253943307 0.483870967741935 30.1 30 1 abnormal middle ear morphology 0.14741543371782 0.309826184060518 0.816805214279069 0.482758620689655 30.1 30 1 decreased retinal photoreceptor cell number 0.14741543371782 0.309826184060518 0.816805214279069 0.482758620689655 30.1 30 1 abnormal CD8-positive, alpha-beta T cell physiology 0.14741543371782 0.309826184060518 0.816805214279069 0.482758620689655 30.1 30 1 increased retinal apoptosis 0.14741543371782 0.309826184060518 0.816805214279069 0.482758620689655 30.1 30 1 abnormal response to infection 0.0300032758041335 0.112485943915147 0.813851126704823 0.481012658227848 30.1 30 1 abnormal female meiosis 0.0698000776971339 0.197671576717944 0.813439258725721 0.480769230769231 30.1 30 1 decreased body temperature 0.0698000776971339 0.197671576717944 0.813439258725721 0.480769230769231 30.1 30 1 abnormal nest building behavior 0.179036344580989 0.369894441150506 0.81213775591176 0.48 30.1 30 1 abnormal innervation pattern to muscle 0.197909126782271 0.403523731861393 0.80919522781063 0.478260869565217 30.1 30 1 hypotension 0.197909126782271 0.403523731861393 0.80919522781063 0.478260869565217 30.1 30 1 abnormal postnatal growth 0.197909126782271 0.403523731861393 0.80919522781063 0.478260869565217 30.1 30 1 conjunctivitis 0.197909126782271 0.403523731861393 0.80919522781063 0.478260869565217 30.1 30 1 abnormal sacral vertebrae morphology 0.197909126782271 0.403523731861393 0.80919522781063 0.478260869565217 30.1 30 1 increased susceptibility to fungal infection 0.197909126782271 0.403523731861393 0.80919522781063 0.478260869565217 30.1 30 1 impaired ovarian folliculogenesis 0.117480005893529 0.307774107067039 0.803677987621013 0.475 30.1 30 1 stereotypic behavior 0.243749435485134 0.473138291665447 0.801451732807658 0.473684210526316 30.1 30 1 unresponsive to tactile stimuli 0.243749435485134 0.473138291665447 0.801451732807658 0.473684210526316 30.1 30 1 abnormal long term depression 0.243749435485134 0.473138291665447 0.801451732807658 0.473684210526316 30.1 30 1 abnormal neurotransmitter level 0.243749435485134 0.473138291665447 0.801451732807658 0.473684210526316 30.1 30 1 abnormal metatarsal bone morphology 0.243749435485134 0.473138291665447 0.801451732807658 0.473684210526316 30.1 30 1 maternal imprinting 0.243749435485134 0.473138291665447 0.801451732807658 0.473684210526316 30.1 30 1 right-sided stomach 0.243749435485134 0.473138291665447 0.801451732807658 0.473684210526316 30.1 30 1 head tilt 0.140641755880318 0.309826184060518 0.798978116348375 0.472222222222222 30.1 30 1 decreased regulatory T cell number 0.154122570488405 0.320819995054316 0.796213486188 0.470588235294118 30.1 30 1 abnormal tarsal bone morphology 0.271861740298452 0.508272137536565 0.796213486188 0.470588235294118 30.1 30 1 abnormal survival 0.271861740298452 0.508272137536565 0.796213486188 0.470588235294118 30.1 30 1 abnormal cued conditioning behavior 0.0944652068610881 0.254930996078161 0.796213486188 0.470588235294118 30.1 30 1 abnormal fontanelle morphology 0.30452621952168 0.531063265826113 0.7895783738031 0.466666666666667 30.1 30 1 no suckling reflex 0.30452621952168 0.531063265826113 0.7895783738031 0.466666666666667 30.1 30 1 joint inflammation 0.30452621952168 0.531063265826113 0.7895783738031 0.466666666666667 30.1 30 1 arthritis 0.30452621952168 0.531063265826113 0.7895783738031 0.466666666666667 30.1 30 1 greasy coat 0.30452621952168 0.531063265826113 0.7895783738031 0.466666666666667 30.1 30 1 abnormal dendritic cell morphology 0.30452621952168 0.531063265826113 0.7895783738031 0.466666666666667 30.1 30 1 abnormal Muller cell morphology 0.30452621952168 0.531063265826113 0.7895783738031 0.466666666666667 30.1 30 1 short femur 0.04359052055495 0.146528945784376 0.788296590728744 0.465909090909091 30.1 30 1 abnormal stria vascularis morphology 0.204390104953381 0.4163967125893 0.785549912712268 0.464285714285714 30.1 30 1 absent corpus callosum 0.204390104953381 0.4163967125893 0.785549912712268 0.464285714285714 30.1 30 1 abnormal excitatory postsynaptic currents 0.0642614307491362 0.195690254680212 0.780901688376692 0.461538461538462 30.1 30 1 increased percent body fat/body weight 0.115606746144477 0.303185852434778 0.780901688376692 0.461538461538462 30.1 30 1 abnormal leukocyte adhesion 0.158856219340117 0.330397028100787 0.780901688376692 0.461538461538462 30.1 30 1 abnormal ocular fundus morphology 0.225252690737349 0.44951148673017 0.780901688376692 0.461538461538462 30.1 30 1 abnormal tectorial membrane morphology 0.225252690737349 0.44951148673017 0.780901688376692 0.461538461538462 30.1 30 1 abnormal sympathetic ganglion morphology 0.342965015842817 0.531063265826113 0.780901688376692 0.461538461538462 30.1 30 1 small trigeminal ganglion 0.342965015842817 0.531063265826113 0.780901688376692 0.461538461538462 30.1 30 1 excessive scratching 0.342965015842817 0.531063265826113 0.780901688376692 0.461538461538462 30.1 30 1 increased synaptic depression 0.342965015842817 0.531063265826113 0.780901688376692 0.461538461538462 30.1 30 1 abnormal GABAergic neuron morphology 0.342965015842817 0.531063265826113 0.780901688376692 0.461538461538462 30.1 30 1 vestibular hair cell degeneration 0.342965015842817 0.531063265826113 0.780901688376692 0.461538461538462 30.1 30 1 small pituitary gland 0.342965015842817 0.531063265826113 0.780901688376692 0.461538461538462 30.1 30 1 hyperalgesia 0.342965015842817 0.531063265826113 0.780901688376692 0.461538461538462 30.1 30 1 increased circulating thyroxine level 0.342965015842817 0.531063265826113 0.780901688376692 0.461538461538462 30.1 30 1 increased renin activity 0.342965015842817 0.531063265826113 0.780901688376692 0.461538461538462 30.1 30 1 decreased cardiac stroke volume 0.342965015842817 0.531063265826113 0.780901688376692 0.461538461538462 30.1 30 1 curly vibrissae 0.248716690405666 0.482027867069805 0.775478759985188 0.458333333333333 30.1 30 1 increased stereotypic behavior 0.248716690405666 0.482027867069805 0.775478759985188 0.458333333333333 30.1 30 1 abnormal vasodilation 0.248716690405666 0.482027867069805 0.775478759985188 0.458333333333333 30.1 30 1 abnormal gametogenesis 0.162170810481019 0.337009098639545 0.769069844613409 0.454545454545455 30.1 30 1 decreased macrophage cell number 0.162170810481019 0.337009098639545 0.769069844613409 0.454545454545455 30.1 30 1 belly spot 0.208199063005224 0.419634480481005 0.769069844613409 0.454545454545455 30.1 30 1 decreased systemic arterial blood pressure 0.208199063005224 0.419634480481005 0.769069844613409 0.454545454545455 30.1 30 1 diarrhea 0.208199063005224 0.419634480481005 0.769069844613409 0.454545454545455 30.1 30 1 abnormal middle ear ossicle morphology 0.208199063005224 0.419634480481005 0.769069844613409 0.454545454545455 30.1 30 1 increased activated T cell number 0.275223756454517 0.513400145617256 0.769069844613409 0.454545454545455 30.1 30 1 abnormal channel response 0.275223756454517 0.513400145617256 0.769069844613409 0.454545454545455 30.1 30 1 cleft upper lip 0.275223756454517 0.513400145617256 0.769069844613409 0.454545454545455 30.1 30 1 decreased susceptibility to viral infection induced morbidity/mortality 0.275223756454517 0.513400145617256 0.769069844613409 0.454545454545455 30.1 30 1 abnormal ear position 0.388967303370691 0.552258086264038 0.769069844613409 0.454545454545455 30.1 30 1 enlarged cranium 0.388967303370691 0.552258086264038 0.769069844613409 0.454545454545455 30.1 30 1 abnormal stomach epithelium morphology 0.388967303370691 0.552258086264038 0.769069844613409 0.454545454545455 30.1 30 1 rectal hemorrhage 0.388967303370691 0.552258086264038 0.769069844613409 0.454545454545455 30.1 30 1 abnormal nerve fiber response 0.388967303370691 0.552258086264038 0.769069844613409 0.454545454545455 30.1 30 1 abnormal pituitary gland development 0.388967303370691 0.552258086264038 0.769069844613409 0.454545454545455 30.1 30 1 enlarged placenta 0.388967303370691 0.552258086264038 0.769069844613409 0.454545454545455 30.1 30 1 abnormal crista ampullaris neuroepithelium morphology 0.388967303370691 0.552258086264038 0.769069844613409 0.454545454545455 30.1 30 1 decreased palatine bone horizontal plate size 0.388967303370691 0.552258086264038 0.769069844613409 0.454545454545455 30.1 30 1 increased number of Howell-Jolly bodies 0.388967303370691 0.552258086264038 0.769069844613409 0.454545454545455 30.1 30 1 increased subcutaneous adipose tissue amount 0.388967303370691 0.552258086264038 0.769069844613409 0.454545454545455 30.1 30 1 abnormal brain ependyma motile cilium morphology 0.388967303370691 0.552258086264038 0.769069844613409 0.454545454545455 30.1 30 1 abnormal phrenic nerve innervation pattern to diaphragm 0.388967303370691 0.552258086264038 0.769069844613409 0.454545454545455 30.1 30 1 thin hypoglossal nerve 0.388967303370691 0.552258086264038 0.769069844613409 0.454545454545455 30.1 30 1 decreased inflammatory response 0.0784829782123486 0.216077928393157 0.765407607258107 0.452380952380952 30.1 30 1 increased food intake 0.0784829782123486 0.216077928393157 0.765407607258107 0.452380952380952 30.1 30 1 autoimmune response 0.228316652181624 0.455260659159751 0.764108103680419 0.451612903225806 30.1 30 1 abnormal social investigation 0.0912683874937978 0.248120343050079 0.761379146167275 0.45 30.1 30 1 abnormal eye physiology 0.130549396593656 0.309826184060518 0.761379146167275 0.45 30.1 30 1 abnormal hearing physiology 0.305325420898329 0.531063265826113 0.761379146167275 0.45 30.1 30 1 abnormal thymocyte activation 0.305325420898329 0.531063265826113 0.761379146167275 0.45 30.1 30 1 abnormal circulating cytokine level 0.305325420898329 0.531063265826113 0.761379146167275 0.45 30.1 30 1 stomach inflammation 0.250682025332275 0.485458573775036 0.758461984687707 0.448275862068966 30.1 30 1 increased susceptibility to pharmacologically induced seizures 0.0751742387622829 0.207542640312074 0.757854242712797 0.447916666666667 30.1 30 1 hyporesponsive to tactile stimuli 0.210273950802027 0.420125664755055 0.756926636540566 0.447368421052632 30.1 30 1 abnormal eye electrophysiology 0.0546814805626174 0.17013156084992 0.755086756529529 0.446280991735537 30.1 30 1 cryptorchism 0.275608120755627 0.513924438065683 0.751979403622 0.444444444444444 30.1 30 1 blepharoptosis 0.339722754608603 0.531063265826113 0.751979403622 0.444444444444444 30.1 30 1 abnormal macrophage chemotaxis 0.339722754608603 0.531063265826113 0.751979403622 0.444444444444444 30.1 30 1 abnormal male meiosis 0.154283935626849 0.321021572456535 0.748897520820271 0.442622950819672 30.1 30 1 abnormal leukocyte migration 0.179779855541434 0.371276372485943 0.748364118027664 0.442307692307692 30.1 30 1 abnormal axon guidance 0.211170298288196 0.421747183453944 0.747607430345128 0.441860465116279 30.1 30 1 decreased susceptibility to induced arthritis 0.180273156152259 0.37214064392427 0.742084937784869 0.43859649122807 30.1 30 1 abnormal crypts of Lieberkuhn morphology 0.274377039428929 0.512589474712325 0.740229725440406 0.4375 30.1 30 1 decreased cochlear coiling 0.379325645779818 0.541039302681937 0.740229725440406 0.4375 30.1 30 1 abnormal molar crown morphology 0.379325645779818 0.541039302681937 0.740229725440406 0.4375 30.1 30 1 bowed tibia 0.379325645779818 0.541039302681937 0.740229725440406 0.4375 30.1 30 1 abnormal epididymis epithelium morphology 0.379325645779818 0.541039302681937 0.740229725440406 0.4375 30.1 30 1 decreased circulating growth hormone level 0.379325645779818 0.541039302681937 0.740229725440406 0.4375 30.1 30 1 abnormal fertilization 0.379325645779818 0.541039302681937 0.740229725440406 0.4375 30.1 30 1 impaired behavioral response to addictive substance 0.379325645779818 0.541039302681937 0.740229725440406 0.4375 30.1 30 1 abnormal lens fiber morphology 0.250005834204413 0.484337626622646 0.737518261244654 0.435897435897436 30.1 30 1 abnormal B cell morphology 0.334696548510091 0.531063265826113 0.735632025282391 0.434782608695652 30.1 30 1 abnormal basicranium morphology 0.334696548510091 0.531063265826113 0.735632025282391 0.434782608695652 30.1 30 1 abnormal CNS synaptic transmission 0.117191625909467 0.307180368229504 0.734888962630591 0.434343434343434 30.1 30 1 abnormal estrous cycle 0.300320743540215 0.531063265826113 0.73317991853145 0.433333333333333 30.1 30 1 abnormal T cell activation 0.166847056990693 0.346582091243714 0.73165563595654 0.432432432432432 30.1 30 1 abnormal pancreatic beta cell physiology 0.272205339106097 0.508723351635174 0.73165563595654 0.432432432432432 30.1 30 1 abnormal photoreceptor outer segment morphology 0.248409909021651 0.481996605843491 0.730616352382739 0.431818181818182 30.1 30 1 enhanced long term potentiation 0.226206115717534 0.451233129789386 0.725122996349786 0.428571428571429 30.1 30 1 abnormal anxiety-related response 0.369833336637898 0.531063265826113 0.725122996349786 0.428571428571429 30.1 30 1 abnormal respiration 0.329021632607311 0.531063265826113 0.725122996349786 0.428571428571429 30.1 30 1 abnormal stapes morphology 0.369833336637898 0.531063265826113 0.725122996349786 0.428571428571429 30.1 30 1 absent atrioventricular cushions 0.425344276602684 0.593906195929933 0.725122996349786 0.428571428571429 30.1 30 1 abnormal endplate potential 0.425344276602684 0.593906195929933 0.725122996349786 0.428571428571429 30.1 30 1 skeletal muscle necrosis 0.425344276602684 0.593906195929933 0.725122996349786 0.428571428571429 30.1 30 1 decreased CNS synapse formation 0.425344276602684 0.593906195929933 0.725122996349786 0.428571428571429 30.1 30 1 abnormal inhibitory postsynaptic currents 0.206900490488761 0.419634480481005 0.721568471857875 0.426470588235294 30.1 30 1 abnormal brain wave pattern 0.263055092486205 0.5040711212224 0.715826547678635 0.423076923076923 30.1 30 1 increased grooming behavior 0.317246348781785 0.531063265826113 0.712401540273474 0.421052631578947 30.1 30 1 altered susceptibility to infection 0.409521532152944 0.572455639915958 0.712401540273474 0.421052631578947 30.1 30 1 osteoarthritis 0.409521532152944 0.572455639915958 0.712401540273474 0.421052631578947 30.1 30 1 decreased susceptibility to bacterial infection induced morbidity/mortality 0.352323698410309 0.531063265826113 0.709528953417532 0.419354838709677 30.1 30 1 abnormal reflex 0.344306119377807 0.531063265826113 0.704980690895625 0.416666666666667 30.1 30 1 hypopigmentation 0.396110732870395 0.55484478470081 0.704980690895625 0.416666666666667 30.1 30 1 increased urine phosphate level 0.479435267569557 0.639975974284557 0.704980690895625 0.416666666666667 30.1 30 1 abnormal alisphenoid bone morphology 0.479435267569557 0.639975974284557 0.704980690895625 0.416666666666667 30.1 30 1 impaired sperm capacitation 0.479435267569557 0.639975974284557 0.704980690895625 0.416666666666667 30.1 30 1 abnormal patella morphology 0.479435267569557 0.639975974284557 0.704980690895625 0.416666666666667 30.1 30 1 abnormal somatic nervous system physiology 0.479435267569557 0.639975974284557 0.704980690895625 0.416666666666667 30.1 30 1 hemoperitoneum 0.479435267569557 0.639975974284557 0.704980690895625 0.416666666666667 30.1 30 1 abnormal behavioral response to addictive substance 0.479435267569557 0.639975974284557 0.704980690895625 0.416666666666667 30.1 30 1 decreased compensatory feeding amount 0.479435267569557 0.639975974284557 0.704980690895625 0.416666666666667 30.1 30 1 abnormal colon goblet cell morphology 0.479435267569557 0.639975974284557 0.704980690895625 0.416666666666667 30.1 30 1 aphagia 0.384320178919101 0.547848965651154 0.700118755096345 0.413793103448276 30.1 30 1 increased double-positive T cell number 0.384320178919101 0.547848965651154 0.700118755096345 0.413793103448276 30.1 30 1 increased susceptibility to viral infection induced morbidity/mortality 0.373713868581184 0.534107008385921 0.6966868004145 0.411764705882353 30.1 30 1 abnormal touch/ nociception 0.454550379616774 0.628512545467885 0.6966868004145 0.411764705882353 30.1 30 1 absence seizures 0.454550379616774 0.628512545467885 0.6966868004145 0.411764705882353 30.1 30 1 increased regulatory T cell number 0.454550379616774 0.628512545467885 0.6966868004145 0.411764705882353 30.1 30 1 decreased growth hormone level 0.454550379616774 0.628512545467885 0.6966868004145 0.411764705882353 30.1 30 1 abnormal basisphenoid bone morphology 0.435332276764855 0.60751138202108 0.692162860152068 0.409090909090909 30.1 30 1 increased coping response 0.435332276764855 0.60751138202108 0.692162860152068 0.409090909090909 30.1 30 1 impaired fertilization 0.35221603086031 0.531063265826113 0.6767814632598 0.4 30.1 30 1 abnormal action potential 0.35221603086031 0.531063265826113 0.6767814632598 0.4 30.1 30 1 arrested T cell differentiation 0.440319802505025 0.614127002372442 0.6767814632598 0.4 30.1 30 1 salivary gland inflammation 0.440319802505025 0.614127002372442 0.6767814632598 0.4 30.1 30 1 decreased chondrocyte number 0.505889647990019 0.674022763457511 0.6767814632598 0.4 30.1 30 1 decreased salivation 0.505889647990019 0.674022763457511 0.6767814632598 0.4 30.1 30 1 audiogenic seizures 0.505889647990019 0.674022763457511 0.6767814632598 0.4 30.1 30 1 increased alcohol consumption 0.505889647990019 0.674022763457511 0.6767814632598 0.4 30.1 30 1 abnormal olfactory nerve morphology 0.505889647990019 0.674022763457511 0.6767814632598 0.4 30.1 30 1 abnormal microglial cell activation 0.505889647990019 0.674022763457511 0.6767814632598 0.4 30.1 30 1 increased susceptibility to parasitic infection 0.323252050759553 0.531063265826113 0.6767814632598 0.4 30.1 30 1 abnormal feces composition 0.457874199081575 0.632932520264194 0.6767814632598 0.4 30.1 30 1 abnormal circulating enzyme level 0.478985606322686 0.639975974284557 0.6767814632598 0.4 30.1 30 1 increased urine glucose level 0.478985606322686 0.639975974284557 0.6767814632598 0.4 30.1 30 1 decreased paired-pulse facilitation 0.478985606322686 0.639975974284557 0.6767814632598 0.4 30.1 30 1 abnormal male reproductive system physiology 0.478985606322686 0.639975974284557 0.6767814632598 0.4 30.1 30 1 decreased sensitivity to xenobiotic induced morbidity/mortality 0.459290934626884 0.634714555491318 0.666527198664955 0.393939393939394 30.1 30 1 small seminal vesicle 0.518532062079082 0.684451315692075 0.650751406980577 0.384615384615385 30.1 30 1 abnormal nerve conduction 0.518532062079082 0.684451315692075 0.650751406980577 0.384615384615385 30.1 30 1 abnormal mast cell morphology 0.564729174898769 0.741300170216721 0.650751406980577 0.384615384615385 30.1 30 1 abnormal insulin secretion 0.564729174898769 0.741300170216721 0.650751406980577 0.384615384615385 30.1 30 1 abnormal retinal inner plexiform layer morphology 0.564729174898769 0.741300170216721 0.650751406980577 0.384615384615385 30.1 30 1 decreased luteinizing hormone level 0.564729174898769 0.741300170216721 0.650751406980577 0.384615384615385 30.1 30 1 decreased cytotoxic T cell cytolysis 0.512267213607555 0.682337185461201 0.64692345752775 0.382352941176471 30.1 30 1 increased vasoconstriction 0.546156233821017 0.717867176554705 0.644553774533143 0.380952380952381 30.1 30 1 hypoalgesia 0.546156233821017 0.717867176554705 0.644553774533143 0.380952380952381 30.1 30 1 abnormal bile salt homeostasis 0.546156233821017 0.717867176554705 0.644553774533143 0.380952380952381 30.1 30 1 abnormal digestive system physiology 0.50357895654717 0.672023956229123 0.64294239009681 0.38 30.1 30 1 absent long term depression 0.535071290144969 0.705908159233948 0.641775525504983 0.379310344827586 30.1 30 1 increased circulating corticosterone level 0.521301489927863 0.687924379944594 0.6391824930787 0.377777777777778 30.1 30 1 increased dopamine level 0.550040689096791 0.722781940902413 0.634482621806063 0.375 30.1 30 1 bowed radius 0.58182804931614 0.742512807732936 0.634482621806063 0.375 30.1 30 1 small epididymis 0.58182804931614 0.742512807732936 0.634482621806063 0.375 30.1 30 1 decreased susceptibility to pharmacologically induced seizures 0.576841570456544 0.742512807732936 0.626649503018333 0.37037037037037 30.1 30 1 decreased chemically-elicited antinociception 0.596514738562243 0.742512807732936 0.623351347739289 0.368421052631579 30.1 30 1 abnormal systemic arterial blood pressure 0.612945141912306 0.743393973918509 0.610983265442875 0.361111111111111 30.1 30 1 abnormal vasoconstriction 0.642165229507704 0.771311447803194 0.604269163624822 0.357142857142857 30.1 30 1 abnormal zigzag hair morphology 0.642165229507704 0.771311447803194 0.604269163624822 0.357142857142857 30.1 30 1 abnormal prepulse inhibition 0.642165229507704 0.771311447803194 0.604269163624822 0.357142857142857 30.1 30 1 abnormal uterus development 0.642165229507704 0.771311447803194 0.604269163624822 0.357142857142857 30.1 30 1 thin skin 0.650787043311098 0.781289947025268 0.597160114641 0.352941176470588 30.1 30 1 decreased pancreatic beta cell number 0.650787043311098 0.781289947025268 0.597160114641 0.352941176470588 30.1 30 1 increased aggression towards mice 0.651252232788521 0.78165979689334 0.597160114641 0.352941176470588 30.1 30 1 enhanced behavioral response to xenobiotic 0.659799655922004 0.791727758854792 0.592183780352325 0.35 30.1 30 1 decreased epididymis weight 0.667861561698546 0.801208408355502 0.588505620225913 0.347826086956522 30.1 30 1 decreased aggression towards males 0.710303020266547 0.84802795984404 0.5639845527165 0.333333333333333 30.1 30 1 abnormal zygomatic bone morphology 0.710303020266547 0.84802795984404 0.5639845527165 0.333333333333333 30.1 30 1 abnormal single cell response 0.724814739198923 0.857539435794207 0.5639845527165 0.333333333333333 30.1 30 1 decreased acute inflammation 0.767402147800948 0.882122385700027 0.54142517060784 0.32 30.1 30 1 irregular coat pigmentation 0.766860493014664 0.88170347879546 0.534301155205105 0.315789473684211 30.1 30 1 decreased grooming behavior 0.766860493014664 0.88170347879546 0.534301155205105 0.315789473684211 30.1 30 1 abnormal response to novelty 0.766860493014664 0.88170347879546 0.534301155205105 0.315789473684211 30.1 30 1 decreased aggression towards mice 0.768700734334914 0.883410984827027 0.528735518171719 0.3125 30.1 30 1 abnormal long term potentiation 0.807692090164036 0.923527499095858 0.528735518171719 0.3125 30.1 30 1 abnormal carpal bone morphology 0.80982495839744 0.925328242541862 0.514942417697674 0.304347826086957 30.1 30 1 abnormal retinal cone cell morphology 0.80982495839744 0.925328242541862 0.514942417697674 0.304347826086957 30.1 30 1 increased susceptibility to age related obesity 0.80982495839744 0.925328242541862 0.514942417697674 0.304347826086957 30.1 30 1 abnormal body temperature homeostasis 0.870097190711521 0.979794822043869 0.491212352365984 0.290322580645161 30.1 30 1 increased circulating luteinizing hormone level 0.873189598132762 0.983054593960283 0.483415330899857 0.285714285714286 30.1 30 1 decreased heart rate variability 0.857857038097495 0.967763892184816 0.46998712726375 0.277777777777778 30.1 30 1 abnormal behavioral response to xenobiotic 0.890355804198506 1 0.445250962670921 0.263157894736842 30.1 30 1 abnormal regulatory T cell physiology 0.908701842331026 1 0.441379215169435 0.260869565217391 30.1 30 1 enhanced coordination 0.940405152895598 1 0.422988414537375 0.25 30.1 30 1 nuclear cataracts 0.916226502627502 1 0.422988414537375 0.25 30.1 30 1 impaired conditioned place preference behavior 0.945857085384148 1 0.40606887795588 0.24 30.1 30 1 abnormal stomach mucosa morphology 0.945857085384148 1 0.40606887795588 0.24 30.1 30 1 impaired behavioral response to xenobiotic 0.976473521239959 1 0.386732264719886 0.228571428571429 30.1 30 1 decreased airway responsiveness 0.952326556542588 1 0.384534922306705 0.227272727272727 30.1 30 1 abnormal artery development 0.00114311083921762 0.00692356112990404 1.12237237237237 1 30.2 30 2 increased neuronal precursor cell number 0.00114311083921762 0.00692356112990404 1.12237237237237 1 30.2 30 2 liver hyperplasia 0.00114311083921762 0.00692356112990404 1.12237237237237 1 30.2 30 2 abnormal inguinal fat pad morphology 0.00114311083921762 0.00692356112990404 1.12237237237237 1 30.2 30 2 abnormal optic chiasm morphology 0.00114311083921762 0.00692356112990404 1.12237237237237 1 30.2 30 2 abnormal lung lobe morphology 0.00114311083921762 0.00692356112990404 1.12237237237237 1 30.2 30 2 abnormal ductus venosus valve topology 0.00114311083921762 0.00692356112990404 1.12237237237237 1 30.2 30 2 increased cardiac muscle glycogen level 0.00114311083921762 0.00692356112990404 1.12237237237237 1 30.2 30 2 abnormal adipose tissue morphology 2.76743837913866e-06 3.63271924438386e-05 1.12237237237237 1 30.2 30 2 delayed intramembranous bone ossification 1.24786289565299e-05 0.000137044545383524 1.12237237237237 1 30.2 30 2 axonal dystrophy 5.62598062609999e-05 0.000513564286510963 1.12237237237237 1 30.2 30 2 tracheoesophageal fistula 5.62598062609999e-05 0.000513564286510963 1.12237237237237 1 30.2 30 2 abnormal thymus involution 0.000119451699844918 0.000988805668433391 1.12237237237237 1 30.2 30 2 loss of dopaminergic neurons 0.000119451699844918 0.000988805668433391 1.12237237237237 1 30.2 30 2 abnormal rostral-caudal body axis extension 0.000119451699844918 0.000988805668433391 1.12237237237237 1 30.2 30 2 pale placenta 0.000119451699844918 0.000988805668433391 1.12237237237237 1 30.2 30 2 prenatal growth retardation 0.000119451699844918 0.000988805668433391 1.12237237237237 1 30.2 30 2 abnormal sphenoid bone morphology 0.000253613316023333 0.00192629961407036 1.12237237237237 1 30.2 30 2 abnormal radial glial cell morphology 0.000253613316023333 0.00192629961407036 1.12237237237237 1 30.2 30 2 pathological neovascularization 0.000253613316023333 0.00192629961407036 1.12237237237237 1 30.2 30 2 increased glycogen level 0.000253613316023333 0.00192629961407036 1.12237237237237 1 30.2 30 2 abnormal palate development 0.000253613316023333 0.00192629961407036 1.12237237237237 1 30.2 30 2 aorta dilation 0.000253613316023333 0.00192629961407036 1.12237237237237 1 30.2 30 2 reduced sympathetic cervical ganglion size 0.000253613316023333 0.00192629961407036 1.12237237237237 1 30.2 30 2 abnormal respiratory mechanics 0.000538440090122407 0.00363465325421842 1.12237237237237 1 30.2 30 2 impaired basement membrane formation 0.000538440090122407 0.00363465325421842 1.12237237237237 1 30.2 30 2 peritoneal inflammation 0.000538440090122407 0.00363465325421842 1.12237237237237 1 30.2 30 2 bifid ureter 0.000538440090122407 0.00363465325421842 1.12237237237237 1 30.2 30 2 abnormal ear physiology 0.000538440090122407 0.00363465325421842 1.12237237237237 1 30.2 30 2 increased heart rate variability 0.000538440090122407 0.00363465325421842 1.12237237237237 1 30.2 30 2 abnormal respiratory conducting tube morphology 0.000538440090122407 0.00363465325421842 1.12237237237237 1 30.2 30 2 abnormal hippocampus neuron morphology 0.000538440090122407 0.00363465325421842 1.12237237237237 1 30.2 30 2 aorta stenosis 0.000538440090122407 0.00363465325421842 1.12237237237237 1 30.2 30 2 decreased trabecular bone connectivity density 0.000538440090122407 0.00363465325421842 1.12237237237237 1 30.2 30 2 dry eyes 0.00242674932541968 0.0128991131500901 1.12237237237237 1 30.2 30 2 abnormal pulmonary circulation 0.00242674932541968 0.0128991131500901 1.12237237237237 1 30.2 30 2 short ureter 0.00242674932541968 0.0128991131500901 1.12237237237237 1 30.2 30 2 decreased aerobic running capacity 0.00242674932541968 0.0128991131500901 1.12237237237237 1 30.2 30 2 abnormal neuron apoptosis 0.00242674932541968 0.0128991131500901 1.12237237237237 1 30.2 30 2 abnormal eyelid aperture 0.00242674932541968 0.0128991131500901 1.12237237237237 1 30.2 30 2 tau protein deposits 0.00242674932541968 0.0128991131500901 1.12237237237237 1 30.2 30 2 abnormal extraembryonic tissue physiology 0.00242674932541968 0.0128991131500901 1.12237237237237 1 30.2 30 2 long femur 0.00242674932541968 0.0128991131500901 1.12237237237237 1 30.2 30 2 accumulation of giant lysosomes in kidney/renal tubule cells 0.00242674932541968 0.0128991131500901 1.12237237237237 1 30.2 30 2 abnormal somite size 0.00242674932541968 0.0128991131500901 1.12237237237237 1 30.2 30 2 craniofacial phenotype 0.00242674932541968 0.0128991131500901 1.12237237237237 1 30.2 30 2 abnormal olfactory bulb mitral cell layer morphology 0.00242674932541968 0.0128991131500901 1.12237237237237 1 30.2 30 2 abnormal cerebellum deep nucleus morphology 0.00242674932541968 0.0128991131500901 1.12237237237237 1 30.2 30 2 delayed suture closure 0.00242674932541968 0.0128991131500901 1.12237237237237 1 30.2 30 2 increased susceptibility to parasitic infection induced morbidity/mortality 0.00242674932541968 0.0128991131500901 1.12237237237237 1 30.2 30 2 absent ureteric bud 0.00242674932541968 0.0128991131500901 1.12237237237237 1 30.2 30 2 increased aorta wall thickness 0.00242674932541968 0.0128991131500901 1.12237237237237 1 30.2 30 2 increased circulating ferritin level 0.00242674932541968 0.0128991131500901 1.12237237237237 1 30.2 30 2 embryo cyst 0.00242674932541968 0.0128991131500901 1.12237237237237 1 30.2 30 2 absent superior cervical ganglion 0.0109359101353609 0.043420712628428 1.12237237237237 1 30.2 30 2 non-obstructive hydrocephaly 0.0109359101353609 0.043420712628428 1.12237237237237 1 30.2 30 2 abnormal pulmonary alveolar duct morphology 0.0109359101353609 0.043420712628428 1.12237237237237 1 30.2 30 2 abnormal hippocampal fimbria morphology 0.0109359101353609 0.043420712628428 1.12237237237237 1 30.2 30 2 bile duct inflammation 0.0109359101353609 0.043420712628428 1.12237237237237 1 30.2 30 2 esophageal atresia 0.0109359101353609 0.043420712628428 1.12237237237237 1 30.2 30 2 increased glycerol level 0.0109359101353609 0.043420712628428 1.12237237237237 1 30.2 30 2 enlarged pancreas 0.0109359101353609 0.043420712628428 1.12237237237237 1 30.2 30 2 ureter obstruction 0.0109359101353609 0.043420712628428 1.12237237237237 1 30.2 30 2 shortened QT interval 0.0109359101353609 0.043420712628428 1.12237237237237 1 30.2 30 2 abnormal heart left atrium morphology 0.0109359101353609 0.043420712628428 1.12237237237237 1 30.2 30 2 absent parietal bone 0.0109359101353609 0.043420712628428 1.12237237237237 1 30.2 30 2 abnormal immature B cell morphology 0.0109359101353609 0.043420712628428 1.12237237237237 1 30.2 30 2 impaired granulocyte bactericidal activity 0.0109359101353609 0.043420712628428 1.12237237237237 1 30.2 30 2 abnormal right lung morphology 0.0109359101353609 0.043420712628428 1.12237237237237 1 30.2 30 2 abnormal eyelid development 0.0109359101353609 0.043420712628428 1.12237237237237 1 30.2 30 2 abnormal aorta tunica adventitia morphology 0.0109359101353609 0.043420712628428 1.12237237237237 1 30.2 30 2 increased transitional stage T1 B cell number 0.0109359101353609 0.043420712628428 1.12237237237237 1 30.2 30 2 abnormal olfactory bulb layer morphology 0.0109359101353609 0.043420712628428 1.12237237237237 1 30.2 30 2 abnormal orbit morphology 0.0109359101353609 0.043420712628428 1.12237237237237 1 30.2 30 2 myocardium hypoplasia 0.0109359101353609 0.043420712628428 1.12237237237237 1 30.2 30 2 abnormal intestinal enteroendocrine cell morphology 0.0109359101353609 0.043420712628428 1.12237237237237 1 30.2 30 2 increased total lung capacity 0.0109359101353609 0.043420712628428 1.12237237237237 1 30.2 30 2 ectopic ureteric bud 0.0109359101353609 0.043420712628428 1.12237237237237 1 30.2 30 2 delayed limb development 0.0109359101353609 0.043420712628428 1.12237237237237 1 30.2 30 2 abnormal Rathke's pouch development 0.0109359101353609 0.043420712628428 1.12237237237237 1 30.2 30 2 thymus cortex atrophy 0.0109359101353609 0.043420712628428 1.12237237237237 1 30.2 30 2 increased bone trabecular spacing 0.0109359101353609 0.043420712628428 1.12237237237237 1 30.2 30 2 abnormal vertebral artery origin 0.0109359101353609 0.043420712628428 1.12237237237237 1 30.2 30 2 abnormal Wolffian duct connection 0.0109359101353609 0.043420712628428 1.12237237237237 1 30.2 30 2 decreased retinal apoptosis 0.0109359101353609 0.043420712628428 1.12237237237237 1 30.2 30 2 increased cardiac cell glucose uptake 0.0109359101353609 0.043420712628428 1.12237237237237 1 30.2 30 2 absent organ of Corti 0.0232139142550413 0.0783508978418117 1.12237237237237 1 30.2 30 2 absent neurocranium 0.0232139142550413 0.0783508978418117 1.12237237237237 1 30.2 30 2 abnormal tooth eruption 0.0232139142550413 0.0783508978418117 1.12237237237237 1 30.2 30 2 abnormal pineal gland morphology 0.0232139142550413 0.0783508978418117 1.12237237237237 1 30.2 30 2 absent lungs 0.0232139142550413 0.0783508978418117 1.12237237237237 1 30.2 30 2 decreased sensitivity to skin irradiation 0.0232139142550413 0.0783508978418117 1.12237237237237 1 30.2 30 2 skin hyperplasia 0.0232139142550413 0.0783508978418117 1.12237237237237 1 30.2 30 2 kinked vibrissae 0.0232139142550413 0.0783508978418117 1.12237237237237 1 30.2 30 2 vascular inflammation 0.0232139142550413 0.0783508978418117 1.12237237237237 1 30.2 30 2 abnormal respiratory sounds 0.0232139142550413 0.0783508978418117 1.12237237237237 1 30.2 30 2 increased hepatic hemangioma incidence 0.0232139142550413 0.0783508978418117 1.12237237237237 1 30.2 30 2 abnormal type I pneumocyte morphology 0.0232139142550413 0.0783508978418117 1.12237237237237 1 30.2 30 2 improved righting response 0.0232139142550413 0.0783508978418117 1.12237237237237 1 30.2 30 2 increased urine microalbumin level 0.0232139142550413 0.0783508978418117 1.12237237237237 1 30.2 30 2 decreased lysosomal enzyme secretion 0.0232139142550413 0.0783508978418117 1.12237237237237 1 30.2 30 2 enhanced NMDA-mediated synaptic currents 0.0232139142550413 0.0783508978418117 1.12237237237237 1 30.2 30 2 gastric polyps 0.0232139142550413 0.0783508978418117 1.12237237237237 1 30.2 30 2 abnormal response to vitamins 0.0232139142550413 0.0783508978418117 1.12237237237237 1 30.2 30 2 ectopic cartilage 0.0232139142550413 0.0783508978418117 1.12237237237237 1 30.2 30 2 increased heart right ventricle weight 0.0232139142550413 0.0783508978418117 1.12237237237237 1 30.2 30 2 abnormal Reichert's membrane morphology 0.0232139142550413 0.0783508978418117 1.12237237237237 1 30.2 30 2 absent frontal bone 0.0232139142550413 0.0783508978418117 1.12237237237237 1 30.2 30 2 abnormal inner cell mass proliferation 0.0232139142550413 0.0783508978418117 1.12237237237237 1 30.2 30 2 erythroblastosis 0.0232139142550413 0.0783508978418117 1.12237237237237 1 30.2 30 2 abnormal mesangial cell morphology 0.0232139142550413 0.0783508978418117 1.12237237237237 1 30.2 30 2 intrahepatic cholestasis 0.0232139142550413 0.0783508978418117 1.12237237237237 1 30.2 30 2 corneal deposits 0.0232139142550413 0.0783508978418117 1.12237237237237 1 30.2 30 2 abnormal hemoglobin content 0.0232139142550413 0.0783508978418117 1.12237237237237 1 30.2 30 2 increased placenta apoptosis 0.0232139142550413 0.0783508978418117 1.12237237237237 1 30.2 30 2 enlarged eye anterior chamber 0.0232139142550413 0.0783508978418117 1.12237237237237 1 30.2 30 2 abnormal arcus anterior morphology 0.0232139142550413 0.0783508978418117 1.12237237237237 1 30.2 30 2 palatal shelf fusion with tongue or mandible 0.0232139142550413 0.0783508978418117 1.12237237237237 1 30.2 30 2 abnormal hyoid bone greater horn morphology 0.0232139142550413 0.0783508978418117 1.12237237237237 1 30.2 30 2 abnormal cerebellum lobule morphology 0.0232139142550413 0.0783508978418117 1.12237237237237 1 30.2 30 2 abnormal cranium size 0.0232139142550413 0.0783508978418117 1.12237237237237 1 30.2 30 2 increased response to stress-induced hyperthermia 0.0232139142550413 0.0783508978418117 1.12237237237237 1 30.2 30 2 leptocytosis 0.0232139142550413 0.0783508978418117 1.12237237237237 1 30.2 30 2 increased T follicular helper cell number 0.0232139142550413 0.0783508978418117 1.12237237237237 1 30.2 30 2 increased thyroid carcinoma incidence 0.0232139142550413 0.0783508978418117 1.12237237237237 1 30.2 30 2 decreased QRS amplitude 0.0232139142550413 0.0783508978418117 1.12237237237237 1 30.2 30 2 calcified aorta 0.0232139142550413 0.0783508978418117 1.12237237237237 1 30.2 30 2 aorta hypoplasia 0.0232139142550413 0.0783508978418117 1.12237237237237 1 30.2 30 2 abnormal blood pressure regulation 0.0232139142550413 0.0783508978418117 1.12237237237237 1 30.2 30 2 abnormal paranode morphology 0.0232139142550413 0.0783508978418117 1.12237237237237 1 30.2 30 2 increased Schwann cell number 0.0232139142550413 0.0783508978418117 1.12237237237237 1 30.2 30 2 preweaning lethality 0.0232139142550413 0.0783508978418117 1.12237237237237 1 30.2 30 2 trachea stenosis 0.0232139142550413 0.0783508978418117 1.12237237237237 1 30.2 30 2 pale lung 0.0232139142550413 0.0783508978418117 1.12237237237237 1 30.2 30 2 abnormal nephrogenic mesenchyme morphogenesis 0.0232139142550413 0.0783508978418117 1.12237237237237 1 30.2 30 2 abnormal lung alveolus development 0.0232139142550413 0.0783508978418117 1.12237237237237 1 30.2 30 2 abnormal circadian regulation of systemic arterial blood pressure 0.0232139142550413 0.0783508978418117 1.12237237237237 1 30.2 30 2 blind ureter 0.0232139142550413 0.0783508978418117 1.12237237237237 1 30.2 30 2 cerebral edema 0.0232139142550413 0.0783508978418117 1.12237237237237 1 30.2 30 2 dilated gastric glands 0.0232139142550413 0.0783508978418117 1.12237237237237 1 30.2 30 2 abnormal eyelid margin morphology 0.0232139142550413 0.0783508978418117 1.12237237237237 1 30.2 30 2 abnormal mammary gland bud morphology 0.0232139142550413 0.0783508978418117 1.12237237237237 1 30.2 30 2 abnormal mitophagy 0.0232139142550413 0.0783508978418117 1.12237237237237 1 30.2 30 2 decreased small intestinal villus height 0.0232139142550413 0.0783508978418117 1.12237237237237 1 30.2 30 2 decreased neuronal precursor proliferation 0.0232139142550413 0.0783508978418117 1.12237237237237 1 30.2 30 2 decreased fibroblast chemotaxis 0.0232139142550413 0.0783508978418117 1.12237237237237 1 30.2 30 2 increased left ventricle weight 6.13665185789895e-07 9.72554680990726e-06 1.12237237237237 1 30.2 30 2 increased hemangioma incidence 2.64965753234771e-05 0.000259489098886414 1.12237237237237 1 30.2 30 2 failure of zygotic cell division 2.64965753234771e-05 0.000259489098886414 1.12237237237237 1 30.2 30 2 abnormal vitelline vein topology 2.64965753234771e-05 0.000259489098886414 1.12237237237237 1 30.2 30 2 broad head 0.00515165906429612 0.023578200409267 1.12237237237237 1 30.2 30 2 polyphalangy 0.00515165906429612 0.023578200409267 1.12237237237237 1 30.2 30 2 mammary gland hyperplasia 0.00515165906429612 0.023578200409267 1.12237237237237 1 30.2 30 2 skin photosensitivity 0.00515165906429612 0.023578200409267 1.12237237237237 1 30.2 30 2 excessive tearing 0.00515165906429612 0.023578200409267 1.12237237237237 1 30.2 30 2 abnormal circulating alanine transaminase level 0.00515165906429612 0.023578200409267 1.12237237237237 1 30.2 30 2 abnormal tumor incidence 0.00515165906429612 0.023578200409267 1.12237237237237 1 30.2 30 2 decreased lateral semicircular canal size 0.00515165906429612 0.023578200409267 1.12237237237237 1 30.2 30 2 decreased cardiomyocyte apoptosis 0.00515165906429612 0.023578200409267 1.12237237237237 1 30.2 30 2 aorta coarctation 0.00515165906429612 0.023578200409267 1.12237237237237 1 30.2 30 2 abnormal nephron morphology 0.00515165906429612 0.023578200409267 1.12237237237237 1 30.2 30 2 abnormal strial marginal cell morphology 0.00515165906429612 0.023578200409267 1.12237237237237 1 30.2 30 2 absent popliteal lymph nodes 0.00515165906429612 0.023578200409267 1.12237237237237 1 30.2 30 2 abnormal retina inner limiting membrane morphology 0.00515165906429612 0.023578200409267 1.12237237237237 1 30.2 30 2 abnormal T wave 0.00515165906429612 0.023578200409267 1.12237237237237 1 30.2 30 2 altered tumor pathology 0.00515165906429612 0.023578200409267 1.12237237237237 1 30.2 30 2 dilated pulmonary alveolar ducts 0.00515165906429612 0.023578200409267 1.12237237237237 1 30.2 30 2 decreased areal bone mineral density 0.00515165906429612 0.023578200409267 1.12237237237237 1 30.2 30 2 decreased femur compact bone thickness 0.00515165906429612 0.023578200409267 1.12237237237237 1 30.2 30 2 ductus venosus stenosis 0.00515165906429612 0.023578200409267 1.12237237237237 1 30.2 30 2 pale kidney 2.60880163259721e-09 7.05368919683213e-08 1.08616681197326 0.967741935483871 30.2 30 2 prolonged QRS complex duration 2.26553321605003e-08 5.02876004897737e-07 1.08228764478764 0.964285714285714 30.2 30 2 abnormal xiphoid process morphology 9.51406468549699e-08 1.87084868815603e-06 1.0792042042042 0.961538461538462 30.2 30 2 increased thymocyte apoptosis 9.51406468549699e-08 1.87084868815603e-06 1.0792042042042 0.961538461538462 30.2 30 2 blindness 3.9727861688595e-07 6.67723351016082e-06 1.07560685685686 0.958333333333333 30.2 30 2 vascular ring 3.34696403372905e-06 4.32497300462391e-05 1.06892606892607 0.952380952380952 30.2 30 2 embryonic lethality at implantation, complete penetrance 3.34696403372905e-06 4.32497300462391e-05 1.06892606892607 0.952380952380952 30.2 30 2 spleen atrophy 6.78307722614809e-06 8.01563163897547e-05 1.06625375375375 0.95 30.2 30 2 kyphoscoliosis 1.3714874958328e-05 0.000148977080606293 1.06330014224751 0.947368421052632 30.2 30 2 abnormal bile duct morphology 2.76594476064283e-05 0.000269815199690158 1.06001835168502 0.944444444444444 30.2 30 2 long tibia 2.76594476064283e-05 0.000269815199690158 1.06001835168502 0.944444444444444 30.2 30 2 abnormal direction of heart looping 5.6800805120904e-09 1.4200201280226e-07 1.05635046811517 0.941176470588235 30.2 30 2 pancreatic islet hyperplasia 2.27431358998976e-08 5.02876004897737e-07 1.0522240990991 0.9375 30.2 30 2 vasculature congestion 0.00011150835711726 0.000937084588949945 1.0522240990991 0.9375 30.2 30 2 abnormal pulmonary elastic fiber morphology 0.00011150835711726 0.000937084588949945 1.0522240990991 0.9375 30.2 30 2 kidney degeneration 0.00011150835711726 0.000937084588949945 1.0522240990991 0.9375 30.2 30 2 impaired somite development 0.00011150835711726 0.000937084588949945 1.0522240990991 0.9375 30.2 30 2 abnormal olfactory nerve morphology 0.000222747824460738 0.00173694424246422 1.04754754754755 0.933333333333333 30.2 30 2 abnormal aorta wall morphology 0.000222747824460738 0.00173694424246422 1.04754754754755 0.933333333333333 30.2 30 2 heterochrony 0.000222747824460738 0.00173694424246422 1.04754754754755 0.933333333333333 30.2 30 2 decreased trophoblast giant cell number 1.79537114654634e-07 3.29593042585536e-06 1.04496738117428 0.931034482758621 30.2 30 2 abnormal outer ear morphology 1.79537114654634e-07 3.29593042585536e-06 1.04496738117428 0.931034482758621 30.2 30 2 abnormal blood flow velocity 0.000443181808448798 0.00314078275930594 1.04220291720292 0.928571428571429 30.2 30 2 translucent skin 0.000443181808448798 0.00314078275930594 1.04220291720292 0.928571428571429 30.2 30 2 irregularly shaped pupil 0.000443181808448798 0.00314078275930594 1.04220291720292 0.928571428571429 30.2 30 2 abnormal sagittal suture morphology 0.000443181808448798 0.00314078275930594 1.04220291720292 0.928571428571429 30.2 30 2 split sternum 0.000443181808448798 0.00314078275930594 1.04220291720292 0.928571428571429 30.2 30 2 abnormal renal tubule epithelial cell primary cilium morphology 0.000443181808448798 0.00314078275930594 1.04220291720292 0.928571428571429 30.2 30 2 decreased response to antigen 0.000443181808448798 0.00314078275930594 1.04220291720292 0.928571428571429 30.2 30 2 pup cannibalization 0.000877754422851938 0.00562735599702112 1.03603603603604 0.923076923076923 30.2 30 2 abnormal grip strength 0.000877754422851938 0.00562735599702112 1.03603603603604 0.923076923076923 30.2 30 2 dystrophic cardiac calcinosis 0.000877754422851938 0.00562735599702112 1.03603603603604 0.923076923076923 30.2 30 2 anal atresia 0.000877754422851938 0.00562735599702112 1.03603603603604 0.923076923076923 30.2 30 2 increased cochlear inner hair cell number 0.000877754422851938 0.00562735599702112 1.03603603603604 0.923076923076923 30.2 30 2 abnormal exocrine pancreas morphology 0.000877754422851938 0.00562735599702112 1.03603603603604 0.923076923076923 30.2 30 2 absent hypoglossal nerve 0.000877754422851938 0.00562735599702112 1.03603603603604 0.923076923076923 30.2 30 2 abnormal nest building behavior 2.72849911952295e-06 3.61018168075178e-05 1.03258258258258 0.92 30.2 30 2 diaphragmatic hernia 2.72849911952295e-06 3.61018168075178e-05 1.03258258258258 0.92 30.2 30 2 altered tumor susceptibility 0.0017293910939859 0.00983282364866271 1.02884134134134 0.916666666666667 30.2 30 2 abnormal respiratory function 0.0017293910939859 0.00983282364866271 1.02884134134134 0.916666666666667 30.2 30 2 abnormal corticospinal tract morphology 0.0017293910939859 0.00983282364866271 1.02884134134134 0.916666666666667 30.2 30 2 increased osteosarcoma incidence 0.0017293910939859 0.00983282364866271 1.02884134134134 0.916666666666667 30.2 30 2 abnormal defecation 0.0017293910939859 0.00983282364866271 1.02884134134134 0.916666666666667 30.2 30 2 increased hepatocyte proliferation 0.0017293910939859 0.00983282364866271 1.02884134134134 0.916666666666667 30.2 30 2 hematuria 0.0017293910939859 0.00983282364866271 1.02884134134134 0.916666666666667 30.2 30 2 decreased renal glomerular filtration rate 0.0017293910939859 0.00983282364866271 1.02884134134134 0.916666666666667 30.2 30 2 decreased prostaglandin level 0.0017293910939859 0.00983282364866271 1.02884134134134 0.916666666666667 30.2 30 2 decreased red blood cell distribution width 0.0017293910939859 0.00983282364866271 1.02884134134134 0.916666666666667 30.2 30 2 increased skeletal muscle glycogen level 0.0017293910939859 0.00983282364866271 1.02884134134134 0.916666666666667 30.2 30 2 persistent right dorsal aorta 0.0017293910939859 0.00983282364866271 1.02884134134134 0.916666666666667 30.2 30 2 increased type II pneumocyte number 0.0017293910939859 0.00983282364866271 1.02884134134134 0.916666666666667 30.2 30 2 embryonic lethality between implantation and placentation, incomplete penetrance 0.0017293910939859 0.00983282364866271 1.02884134134134 0.916666666666667 30.2 30 2 abnormal artery morphology 3.6068543107932e-08 7.75661312186568e-07 1.02616902616903 0.914285714285714 30.2 30 2 abnormal Wolffian duct morphology 1.04482698304997e-05 0.000116547404499408 1.02477477477477 0.91304347826087 30.2 30 2 prolonged PR interval 2.03367361697694e-05 0.000209907183495027 1.02033852033852 0.909090909090909 30.2 30 2 abnormal occipital bone morphology 2.03367361697694e-05 0.000209907183495027 1.02033852033852 0.909090909090909 30.2 30 2 premature suture closure 0.00338670783111314 0.0168556843461976 1.02033852033852 0.909090909090909 30.2 30 2 decreased atrioventricular cushion size 0.00338670783111314 0.0168556843461976 1.02033852033852 0.909090909090909 30.2 30 2 delayed hepatic development 0.00338670783111314 0.0168556843461976 1.02033852033852 0.909090909090909 30.2 30 2 abnormal eye distance/ position 0.00338670783111314 0.0168556843461976 1.02033852033852 0.909090909090909 30.2 30 2 failure of somite differentiation 0.00338670783111314 0.0168556843461976 1.02033852033852 0.909090909090909 30.2 30 2 abnormal proximal-distal axis patterning 0.00338670783111314 0.0168556843461976 1.02033852033852 0.909090909090909 30.2 30 2 abnormal larynx morphology 0.00338670783111314 0.0168556843461976 1.02033852033852 0.909090909090909 30.2 30 2 fatigue 0.00338670783111314 0.0168556843461976 1.02033852033852 0.909090909090909 30.2 30 2 retinal detachment 0.00338670783111314 0.0168556843461976 1.02033852033852 0.909090909090909 30.2 30 2 patent ductus arteriosus 0.00338670783111314 0.0168556843461976 1.02033852033852 0.909090909090909 30.2 30 2 fused joints 0.00338670783111314 0.0168556843461976 1.02033852033852 0.909090909090909 30.2 30 2 abnormal coronal suture morphology 0.00338670783111314 0.0168556843461976 1.02033852033852 0.909090909090909 30.2 30 2 hypolactation 0.00338670783111314 0.0168556843461976 1.02033852033852 0.909090909090909 30.2 30 2 kidney cortex cysts 2.64202031100539e-07 4.67759823745617e-06 1.01714996246246 0.90625 30.2 30 2 preaxial polydactyly 5.10191780045304e-07 8.29478465923329e-06 1.01375569117505 0.903225806451613 30.2 30 2 liver fibrosis 6.91977680929791e-09 1.70688055674852e-07 1.01287262872629 0.902439024390244 30.2 30 2 abnormal pericardium morphology 7.61010545479477e-05 0.00067009335641777 1.01013513513514 0.9 30.2 30 2 anencephaly 7.61010545479477e-05 0.00067009335641777 1.01013513513514 0.9 30.2 30 2 decreased myocardial infarction size 7.61010545479477e-05 0.00067009335641777 1.01013513513514 0.9 30.2 30 2 abnormal hyoid bone morphology 7.61010545479477e-05 0.00067009335641777 1.01013513513514 0.9 30.2 30 2 kidney atrophy 7.61010545479477e-05 0.00067009335641777 1.01013513513514 0.9 30.2 30 2 abnormal incus morphology 7.61010545479477e-05 0.00067009335641777 1.01013513513514 0.9 30.2 30 2 absent ductus venosus valve 7.61010545479477e-05 0.00067009335641777 1.01013513513514 0.9 30.2 30 2 retarded hair growth 0.00658514758107452 0.0283469885476634 1.01013513513514 0.9 30.2 30 2 jaundice 0.00658514758107452 0.0283469885476634 1.01013513513514 0.9 30.2 30 2 enlarged testis 0.00658514758107452 0.0283469885476634 1.01013513513514 0.9 30.2 30 2 fused cornea and lens 0.00658514758107452 0.0283469885476634 1.01013513513514 0.9 30.2 30 2 abnormal gland morphology 0.00658514758107452 0.0283469885476634 1.01013513513514 0.9 30.2 30 2 ketoaciduria 0.00658514758107452 0.0283469885476634 1.01013513513514 0.9 30.2 30 2 abnormal PNS synaptic transmission 0.00658514758107452 0.0283469885476634 1.01013513513514 0.9 30.2 30 2 abnormal neuron specification 0.00658514758107452 0.0283469885476634 1.01013513513514 0.9 30.2 30 2 aneurysm 0.00658514758107452 0.0283469885476634 1.01013513513514 0.9 30.2 30 2 absent seminal vesicle 0.00658514758107452 0.0283469885476634 1.01013513513514 0.9 30.2 30 2 abnormal submandibular gland morphology 0.00658514758107452 0.0283469885476634 1.01013513513514 0.9 30.2 30 2 abnormal gas homeostasis 0.00658514758107452 0.0283469885476634 1.01013513513514 0.9 30.2 30 2 abnormal plasma membrane morphology 0.00658514758107452 0.0283469885476634 1.01013513513514 0.9 30.2 30 2 abnormal gonadal fat pad morphology 0.00658514758107452 0.0283469885476634 1.01013513513514 0.9 30.2 30 2 osteosclerosis 0.00658514758107452 0.0283469885476634 1.01013513513514 0.9 30.2 30 2 decreased transitional stage T2 B cell number 0.00658514758107452 0.0283469885476634 1.01013513513514 0.9 30.2 30 2 abnormal retinal blood vessel pattern 0.00658514758107452 0.0283469885476634 1.01013513513514 0.9 30.2 30 2 abnormal vibrissa follicle morphology 0.00658514758107452 0.0283469885476634 1.01013513513514 0.9 30.2 30 2 abnormal heart and great artery attachment 0.00658514758107452 0.0283469885476634 1.01013513513514 0.9 30.2 30 2 abnormal left subclavian artery morphology 0.00658514758107452 0.0283469885476634 1.01013513513514 0.9 30.2 30 2 thin ventricle myocardium compact layer 0.00658514758107452 0.0283469885476634 1.01013513513514 0.9 30.2 30 2 fusion of atlas and odontoid process 0.00658514758107452 0.0283469885476634 1.01013513513514 0.9 30.2 30 2 abnormal pulmonary interalveolar septum morphology 0.00658514758107452 0.0283469885476634 1.01013513513514 0.9 30.2 30 2 abnormal adaptive thermogenesis 0.00658514758107452 0.0283469885476634 1.01013513513514 0.9 30.2 30 2 lethality during fetal growth through weaning, complete penetrance 0.00658514758107452 0.0283469885476634 1.01013513513514 0.9 30.2 30 2 decreased circulating lactate level 0.00658514758107452 0.0283469885476634 1.01013513513514 0.9 30.2 30 2 increased fatty acid oxidation 0.00658514758107452 0.0283469885476634 1.01013513513514 0.9 30.2 30 2 increased mortality induced by gamma-irradiation 1.88422477428228e-06 2.56120717269245e-05 1.00626488557523 0.896551724137931 30.2 30 2 vertebral transformation 6.78559285444109e-10 2.05843441773441e-08 1.00545858358358 0.895833333333333 30.2 30 2 abnormal cell morphology 1.18481449864126e-21 1.43767125140007e-19 1.00422791212265 0.894736842105263 30.2 30 2 abnormal blastocyst morphology 0.00014618831511528 0.0011883772348015 1.00422791212265 0.894736842105263 30.2 30 2 increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 0.00014618831511528 0.0011883772348015 1.00422791212265 0.894736842105263 30.2 30 2 embryonic lethality between implantation and somite formation, incomplete penetrance 0.00014618831511528 0.0011883772348015 1.00422791212265 0.894736842105263 30.2 30 2 myoclonus 3.60199195423102e-06 4.54820050058358e-05 1.00211818961819 0.892857142857143 30.2 30 2 abnormal somite shape 3.60199195423102e-06 4.54820050058358e-05 1.00211818961819 0.892857142857143 30.2 30 2 hypoxia 3.60199195423102e-06 4.54820050058358e-05 1.00211818961819 0.892857142857143 30.2 30 2 abnormal brainstem morphology 3.60199195423102e-06 4.54820050058358e-05 1.00211818961819 0.892857142857143 30.2 30 2 abnormal renal tubule epithelium morphology 3.60199195423102e-06 4.54820050058358e-05 1.00211818961819 0.892857142857143 30.2 30 2 subcutaneous edema 3.60199195423102e-06 4.54820050058358e-05 1.00211818961819 0.892857142857143 30.2 30 2 abnormal lysosome morphology 1.76805396329895e-07 3.26991392840605e-06 0.997664330997664 0.888888888888889 30.2 30 2 abnormal body wall morphology 0.000279340295662236 0.00207420592674571 0.997664330997664 0.888888888888889 30.2 30 2 absent ureter 0.000279340295662236 0.00207420592674571 0.997664330997664 0.888888888888889 30.2 30 2 abnormal eye anterior chamber morphology 0.000279340295662236 0.00207420592674571 0.997664330997664 0.888888888888889 30.2 30 2 atrioventricular block 0.000279340295662236 0.00207420592674571 0.997664330997664 0.888888888888889 30.2 30 2 increased effector memory CD8-positive, alpha-beta T cell number 0.000279340295662236 0.00207420592674571 0.997664330997664 0.888888888888889 30.2 30 2 abnormal aerobic respiration 0.000279340295662236 0.00207420592674571 0.997664330997664 0.888888888888889 30.2 30 2 abnormal metanephric mesenchyme morphology 0.000279340295662236 0.00207420592674571 0.997664330997664 0.888888888888889 30.2 30 2 abnormal hypoglossal nerve topology 0.000279340295662236 0.00207420592674571 0.997664330997664 0.888888888888889 30.2 30 2 heart hyperplasia 0.0126958572150361 0.0483628557770328 0.997664330997664 0.888888888888889 30.2 30 2 distorted hair follicle pattern 0.0126958572150361 0.0483628557770328 0.997664330997664 0.888888888888889 30.2 30 2 abnormal head movements 0.0126958572150361 0.0483628557770328 0.997664330997664 0.888888888888889 30.2 30 2 synostosis 0.0126958572150361 0.0483628557770328 0.997664330997664 0.888888888888889 30.2 30 2 absent enteric neurons 0.0126958572150361 0.0483628557770328 0.997664330997664 0.888888888888889 30.2 30 2 abnormal geniculate ganglion morphology 0.0126958572150361 0.0483628557770328 0.997664330997664 0.888888888888889 30.2 30 2 dilated uterus 0.0126958572150361 0.0483628557770328 0.997664330997664 0.888888888888889 30.2 30 2 abnormal ion homeostasis 0.0126958572150361 0.0483628557770328 0.997664330997664 0.888888888888889 30.2 30 2 decreased level of surface class I molecules 0.0126958572150361 0.0483628557770328 0.997664330997664 0.888888888888889 30.2 30 2 abnormal lung volume 0.0126958572150361 0.0483628557770328 0.997664330997664 0.888888888888889 30.2 30 2 increased pheochromocytoma incidence 0.0126958572150361 0.0483628557770328 0.997664330997664 0.888888888888889 30.2 30 2 abnormal germ cell morphology 0.0126958572150361 0.0483628557770328 0.997664330997664 0.888888888888889 30.2 30 2 abnormal posterior semicircular canal morphology 0.0126958572150361 0.0483628557770328 0.997664330997664 0.888888888888889 30.2 30 2 polycythemia 0.0126958572150361 0.0483628557770328 0.997664330997664 0.888888888888889 30.2 30 2 pancreas cysts 0.0126958572150361 0.0483628557770328 0.997664330997664 0.888888888888889 30.2 30 2 abnormal thymus physiology 0.0126958572150361 0.0483628557770328 0.997664330997664 0.888888888888889 30.2 30 2 decreased cellular sensitivity to ionizing radiation 0.0126958572150361 0.0483628557770328 0.997664330997664 0.888888888888889 30.2 30 2 abnormal stria vascularis vasculature morphology 0.0126958572150361 0.0483628557770328 0.997664330997664 0.888888888888889 30.2 30 2 decreased cochlear hair cell number 0.0126958572150361 0.0483628557770328 0.997664330997664 0.888888888888889 30.2 30 2 hemothorax 0.0126958572150361 0.0483628557770328 0.997664330997664 0.888888888888889 30.2 30 2 decreased susceptibility to atherosclerosis 0.0126958572150361 0.0483628557770328 0.997664330997664 0.888888888888889 30.2 30 2 positive geotaxis 0.0126958572150361 0.0483628557770328 0.997664330997664 0.888888888888889 30.2 30 2 eye opacity 0.0126958572150361 0.0483628557770328 0.997664330997664 0.888888888888889 30.2 30 2 abnormal telomere morphology 0.0126958572150361 0.0483628557770328 0.997664330997664 0.888888888888889 30.2 30 2 iris coloboma 0.0126958572150361 0.0483628557770328 0.997664330997664 0.888888888888889 30.2 30 2 fusion of atlas and occipital bones 0.0126958572150361 0.0483628557770328 0.997664330997664 0.888888888888889 30.2 30 2 decreased susceptibility to parasitic infection induced morbidity/mortality 0.0126958572150361 0.0483628557770328 0.997664330997664 0.888888888888889 30.2 30 2 abnormal pulmonary alveolar system morphology 0.0126958572150361 0.0483628557770328 0.997664330997664 0.888888888888889 30.2 30 2 abnormal oxidative phosphorylation 0.0126958572150361 0.0483628557770328 0.997664330997664 0.888888888888889 30.2 30 2 trigeminal neuroma 0.0126958572150361 0.0483628557770328 0.997664330997664 0.888888888888889 30.2 30 2 symmetric azygos veins 0.0126958572150361 0.0483628557770328 0.997664330997664 0.888888888888889 30.2 30 2 cerebellum atrophy 0.0126958572150361 0.0483628557770328 0.997664330997664 0.888888888888889 30.2 30 2 adipose tissue inflammation 0.0126958572150361 0.0483628557770328 0.997664330997664 0.888888888888889 30.2 30 2 thin epidermis 6.85932257607266e-06 8.03456307037647e-05 0.997664330997664 0.888888888888889 30.2 30 2 decreased triglyceride level 3.35036211812195e-07 5.8484391360199e-06 0.994101244101244 0.885714285714286 30.2 30 2 eyelids open at birth 4.51204905020561e-10 1.4297735047626e-08 0.992867867867868 0.884615384615385 30.2 30 2 delayed endochondral bone ossification 1.67526776343619e-08 3.94997967919197e-07 0.991863956980236 0.883720930232558 30.2 30 2 enlarged liver sinusoidal spaces 6.32732816841423e-07 9.93011281951445e-06 0.990328563857976 0.882352941176471 30.2 30 2 hyperlipidemia 0.000530641138401993 0.00363127876691873 0.990328563857976 0.882352941176471 30.2 30 2 abnormal ectoplacental cone morphology 0.000530641138401993 0.00363127876691873 0.990328563857976 0.882352941176471 30.2 30 2 abnormal melanosome morphology 0.000530641138401993 0.00363127876691873 0.990328563857976 0.882352941176471 30.2 30 2 abnormal tarsal bone morphology 0.000530641138401993 0.00363127876691873 0.990328563857976 0.882352941176471 30.2 30 2 coloboma 0.000530641138401993 0.00363127876691873 0.990328563857976 0.882352941176471 30.2 30 2 common atrium 0.000530641138401993 0.00363127876691873 0.990328563857976 0.882352941176471 30.2 30 2 small lung 8.50495280621481e-10 2.54892410909149e-08 0.990328563857976 0.882352941176471 30.2 30 2 abnormal thyroid gland morphology 2.45602627750289e-05 0.000245849712888871 0.987687687687688 0.88 30.2 30 2 abnormal egg cylinder morphology 2.45602627750289e-05 0.000245849712888871 0.987687687687688 0.88 30.2 30 2 increased cellular sensitivity to ionizing radiation 2.45602627750289e-05 0.000245849712888871 0.987687687687688 0.88 30.2 30 2 increased liver glycogen level 2.45602627750289e-05 0.000245849712888871 0.987687687687688 0.88 30.2 30 2 abnormal aorta morphology 1.19067728996107e-06 1.68284645385123e-05 0.986327236327236 0.878787878787879 30.2 30 2 increased cardiomyocyte apoptosis 1.19067728996107e-06 1.68284645385123e-05 0.986327236327236 0.878787878787879 30.2 30 2 abnormal locomotor coordination 1.19067728996107e-06 1.68284645385123e-05 0.986327236327236 0.878787878787879 30.2 30 2 increased neuron apoptosis 2.14590692653205e-14 1.25598670111729e-12 0.98380788195603 0.876543209876543 30.2 30 2 abnormal foregut morphology 4.61479833367125e-05 0.000434000410397249 0.982075825825826 0.875 30.2 30 2 abnormal impulse conducting system conduction 4.61479833367125e-05 0.000434000410397249 0.982075825825826 0.875 30.2 30 2 increased hemangiosarcoma incidence 4.61479833367125e-05 0.000434000410397249 0.982075825825826 0.875 30.2 30 2 abnormal lung saccule morphology 4.61479833367125e-05 0.000434000410397249 0.982075825825826 0.875 30.2 30 2 failure of tooth eruption 0.00100142409586508 0.00618104391533197 0.982075825825826 0.875 30.2 30 2 abnormal hair follicle orientation 0.00100142409586508 0.00618104391533197 0.982075825825826 0.875 30.2 30 2 disorganized yolk sac vascular plexus 0.00100142409586508 0.00618104391533197 0.982075825825826 0.875 30.2 30 2 impaired muscle relaxation 0.00100142409586508 0.00618104391533197 0.982075825825826 0.875 30.2 30 2 increased pancreatic beta cell number 0.00100142409586508 0.00618104391533197 0.982075825825826 0.875 30.2 30 2 increased cochlear outer hair cell number 0.00100142409586508 0.00618104391533197 0.982075825825826 0.875 30.2 30 2 loose skin 0.00100142409586508 0.00618104391533197 0.982075825825826 0.875 30.2 30 2 impaired behavioral response to addictive substance 0.00100142409586508 0.00618104391533197 0.982075825825826 0.875 30.2 30 2 increased heart left ventricle size 0.00100142409586508 0.00618104391533197 0.982075825825826 0.875 30.2 30 2 abnormal ear pigmentation 0.0242260272364313 0.0787741735302259 0.982075825825826 0.875 30.2 30 2 abnormal exoccipital bone morphology 0.0242260272364313 0.0787741735302259 0.982075825825826 0.875 30.2 30 2 schistocytosis 0.0242260272364313 0.0787741735302259 0.982075825825826 0.875 30.2 30 2 increased sensitivity to skin irradiation 0.0242260272364313 0.0787741735302259 0.982075825825826 0.875 30.2 30 2 abnormal pupil morphology 0.0242260272364313 0.0787741735302259 0.982075825825826 0.875 30.2 30 2 absent eyelids 0.0242260272364313 0.0787741735302259 0.982075825825826 0.875 30.2 30 2 abnormal urination 0.0242260272364313 0.0787741735302259 0.982075825825826 0.875 30.2 30 2 abnormal hepatobiliary system morphology 0.0242260272364313 0.0787741735302259 0.982075825825826 0.875 30.2 30 2 coarse hair 0.0242260272364313 0.0787741735302259 0.982075825825826 0.875 30.2 30 2 altered response to CNS ischemic injury 0.0242260272364313 0.0787741735302259 0.982075825825826 0.875 30.2 30 2 hypospadia 0.0242260272364313 0.0787741735302259 0.982075825825826 0.875 30.2 30 2 early eyelid opening 0.0242260272364313 0.0787741735302259 0.982075825825826 0.875 30.2 30 2 abnormal soft palate morphology 0.0242260272364313 0.0787741735302259 0.982075825825826 0.875 30.2 30 2 calcified muscle 0.0242260272364313 0.0787741735302259 0.982075825825826 0.875 30.2 30 2 loss of GABAergic neurons 0.0242260272364313 0.0787741735302259 0.982075825825826 0.875 30.2 30 2 colon polyps 0.0242260272364313 0.0787741735302259 0.982075825825826 0.875 30.2 30 2 abnormal perineum morphology 0.0242260272364313 0.0787741735302259 0.982075825825826 0.875 30.2 30 2 liver cysts 0.0242260272364313 0.0787741735302259 0.982075825825826 0.875 30.2 30 2 elevated level of mitotic sister chromatid exchange 0.0242260272364313 0.0787741735302259 0.982075825825826 0.875 30.2 30 2 binucleate 0.0242260272364313 0.0787741735302259 0.982075825825826 0.875 30.2 30 2 increased left ventricle systolic pressure 0.0242260272364313 0.0787741735302259 0.982075825825826 0.875 30.2 30 2 thin stria vascularis 0.0242260272364313 0.0787741735302259 0.982075825825826 0.875 30.2 30 2 bowed fibula 0.0242260272364313 0.0787741735302259 0.982075825825826 0.875 30.2 30 2 absent interparietal bone 0.0242260272364313 0.0787741735302259 0.982075825825826 0.875 30.2 30 2 abnormal kidney epithelium morphology 0.0242260272364313 0.0787741735302259 0.982075825825826 0.875 30.2 30 2 non-pigmented tail tip 0.0242260272364313 0.0787741735302259 0.982075825825826 0.875 30.2 30 2 abnormal canal of Schlemm morphology 0.0242260272364313 0.0787741735302259 0.982075825825826 0.875 30.2 30 2 ocular hypertension 0.0242260272364313 0.0787741735302259 0.982075825825826 0.875 30.2 30 2 decreased susceptibility to autoimmune disorder 0.0242260272364313 0.0787741735302259 0.982075825825826 0.875 30.2 30 2 abnormal ilium morphology 0.0242260272364313 0.0787741735302259 0.982075825825826 0.875 30.2 30 2 stomach epithelial hyperplasia 0.0242260272364313 0.0787741735302259 0.982075825825826 0.875 30.2 30 2 abnormal epidermal lamellar body morphology 0.0242260272364313 0.0787741735302259 0.982075825825826 0.875 30.2 30 2 abnormal mitotic spindle assembly checkpoint 0.0242260272364313 0.0787741735302259 0.982075825825826 0.875 30.2 30 2 decreased hippocampus pyramidal cell number 0.0242260272364313 0.0787741735302259 0.982075825825826 0.875 30.2 30 2 pleural effusion 0.0242260272364313 0.0787741735302259 0.982075825825826 0.875 30.2 30 2 pulmonary artery hypoplasia 0.0242260272364313 0.0787741735302259 0.982075825825826 0.875 30.2 30 2 lung situs inversus 0.0242260272364313 0.0787741735302259 0.982075825825826 0.875 30.2 30 2 abnormal anterior commissure pars posterior morphology 0.0242260272364313 0.0787741735302259 0.982075825825826 0.875 30.2 30 2 decreased alveolar lamellar body number 0.0242260272364313 0.0787741735302259 0.982075825825826 0.875 30.2 30 2 decreased lung compliance 0.0242260272364313 0.0787741735302259 0.982075825825826 0.875 30.2 30 2 abnormal bronchiole epithelium morphology 0.0242260272364313 0.0787741735302259 0.982075825825826 0.875 30.2 30 2 abnormal foramen magnum morphology 0.0242260272364313 0.0787741735302259 0.982075825825826 0.875 30.2 30 2 abnormal bronchus epithelium morphology 0.0242260272364313 0.0787741735302259 0.982075825825826 0.875 30.2 30 2 decreased surfactant secretion 0.0242260272364313 0.0787741735302259 0.982075825825826 0.875 30.2 30 2 lethality during fetal growth through weaning, incomplete penetrance 0.0242260272364313 0.0787741735302259 0.982075825825826 0.875 30.2 30 2 impaired neuron differentiation 0.0242260272364313 0.0787741735302259 0.982075825825826 0.875 30.2 30 2 increased cardiac stroke volume 0.0242260272364313 0.0787741735302259 0.982075825825826 0.875 30.2 30 2 prolonged PQ interval 0.0242260272364313 0.0787741735302259 0.982075825825826 0.875 30.2 30 2 increased cornea thickness 0.0242260272364313 0.0787741735302259 0.982075825825826 0.875 30.2 30 2 absent hypoglossal canal 0.0242260272364313 0.0787741735302259 0.982075825825826 0.875 30.2 30 2 retropleural edema 0.0242260272364313 0.0787741735302259 0.982075825825826 0.875 30.2 30 2 abnormal umbilical vein topology 0.0242260272364313 0.0787741735302259 0.982075825825826 0.875 30.2 30 2 increased mammary gland apoptosis 0.0242260272364313 0.0787741735302259 0.982075825825826 0.875 30.2 30 2 increased brain apoptosis 0.0242260272364313 0.0787741735302259 0.982075825825826 0.875 30.2 30 2 decreased basal metabolism 0.0242260272364313 0.0787741735302259 0.982075825825826 0.875 30.2 30 2 decreased vascular endothelial cell proliferation 0.0242260272364313 0.0787741735302259 0.982075825825826 0.875 30.2 30 2 abnormal head morphology 5.35197358310559e-10 1.66412928599689e-08 0.97952497952498 0.872727272727273 30.2 30 2 abnormal cell nucleus morphology 1.04634319121554e-08 2.55174381191044e-07 0.97909079292058 0.872340425531915 30.2 30 2 increased circulating creatinine level 7.27994131312913e-15 4.5845200041541e-13 0.978813115441022 0.872093023255814 30.2 30 2 increased embryonic tissue cell apoptosis 1.39076901359567e-13 7.06028147208005e-12 0.978478478478478 0.871794871794872 30.2 30 2 decreased thymus weight 4.16760319365022e-06 5.18345647210246e-05 0.977550130775937 0.870967741935484 30.2 30 2 inner cell mass degeneration 4.16760319365022e-06 5.18345647210246e-05 0.977550130775937 0.870967741935484 30.2 30 2 abnormal myelin sheath morphology 1.94597081322519e-08 4.4613846985232e-07 0.975975975975976 0.869565217391304 30.2 30 2 abnormal blood vessel physiology 8.62598450982341e-05 0.000743748231132955 0.975975975975976 0.869565217391304 30.2 30 2 persistence of hyaloid vascular system 3.84919382077675e-07 6.53574718715507e-06 0.974691797060218 0.868421052631579 30.2 30 2 enlarged kidney 1.84697656399113e-09 5.1913606812745e-08 0.974134511870361 0.867924528301887 30.2 30 2 atrioventricular septal defect 1.84697656399113e-09 5.1913606812745e-08 0.974134511870361 0.867924528301887 30.2 30 2 delayed bone ossification 8.86625866581162e-13 4.0842256354086e-11 0.972722722722723 0.866666666666667 30.2 30 2 abnormal myocardial trabeculae morphology 3.60807476176807e-08 7.75661312186568e-07 0.972722722722723 0.866666666666667 30.2 30 2 abnormal optic cup morphology 7.7479328899281e-06 8.94414679847216e-05 0.972722722722723 0.866666666666667 30.2 30 2 abnormal brain vasculature morphology 7.7479328899281e-06 8.94414679847216e-05 0.972722722722723 0.866666666666667 30.2 30 2 absent incisors 0.00187600270437119 0.0104280597254153 0.972722722722723 0.866666666666667 30.2 30 2 absent egg cylinders 0.00187600270437119 0.0104280597254153 0.972722722722723 0.866666666666667 30.2 30 2 abnormal pericyte morphology 0.00187600270437119 0.0104280597254153 0.972722722722723 0.866666666666667 30.2 30 2 abnormal placenta size 0.00187600270437119 0.0104280597254153 0.972722722722723 0.866666666666667 30.2 30 2 immune system phenotype 0.00187600270437119 0.0104280597254153 0.972722722722723 0.866666666666667 30.2 30 2 herniated liver 0.00187600270437119 0.0104280597254153 0.972722722722723 0.866666666666667 30.2 30 2 decreased brown adipose tissue mass 0.00187600270437119 0.0104280597254153 0.972722722722723 0.866666666666667 30.2 30 2 decreased kidney weight 3.41736198091306e-09 9.14052465324864e-08 0.971283783783784 0.865384615384615 30.2 30 2 kidney cysts 1.63760811262994e-12 7.20982332772914e-11 0.970700430159889 0.864864864864865 30.2 30 2 malocclusion 7.13120452857335e-07 1.09838212166107e-05 0.970700430159889 0.864864864864865 30.2 30 2 impaired skeletal muscle contractility 7.13120452857335e-07 1.09838212166107e-05 0.970700430159889 0.864864864864865 30.2 30 2 abnormal calcium ion homeostasis 7.13120452857335e-07 1.09838212166107e-05 0.970700430159889 0.864864864864865 30.2 30 2 abnormal facial nerve morphology 0.00016032578965507 0.00128029021434025 0.969321594321594 0.863636363636364 30.2 30 2 intracerebral hemorrhage 0.00016032578965507 0.00128029021434025 0.969321594321594 0.863636363636364 30.2 30 2 increased circulating creatine kinase level 0.00016032578965507 0.00128029021434025 0.969321594321594 0.863636363636364 30.2 30 2 abnormal parietal bone morphology 1.43380368289108e-05 0.000154732610030003 0.967562389976183 0.862068965517241 30.2 30 2 heart right ventricle hypertrophy 1.31606726780246e-06 1.8340153101729e-05 0.966487320653988 0.861111111111111 30.2 30 2 abnormal pharyngeal arch morphology 1.31606726780246e-06 1.8340153101729e-05 0.966487320653988 0.861111111111111 30.2 30 2 abnormal lung development 9.54861475882612e-14 5.10799552958709e-12 0.963919802155096 0.858823529411765 30.2 30 2 spina bifida 2.25492062153439e-07 4.02087100076472e-06 0.962033462033462 0.857142857142857 30.2 30 2 small ears 0.000296150466510862 0.00216350744624308 0.962033462033462 0.857142857142857 30.2 30 2 abnormal eye pigmentation 0.000296150466510862 0.00216350744624308 0.962033462033462 0.857142857142857 30.2 30 2 liver degeneration 0.000296150466510862 0.00216350744624308 0.962033462033462 0.857142857142857 30.2 30 2 abnormal stapes morphology 0.000296150466510862 0.00216350744624308 0.962033462033462 0.857142857142857 30.2 30 2 abnormal tumor vascularization 0.000296150466510862 0.00216350744624308 0.962033462033462 0.857142857142857 30.2 30 2 increased muscle cell glucose uptake 0.000296150466510862 0.00216350744624308 0.962033462033462 0.857142857142857 30.2 30 2 rib bifurcation 2.64033063071223e-05 0.000259489098886414 0.962033462033462 0.857142857142857 30.2 30 2 small superior cervical ganglion 2.64033063071223e-05 0.000259489098886414 0.962033462033462 0.857142857142857 30.2 30 2 premature aging 2.64033063071223e-05 0.000259489098886414 0.962033462033462 0.857142857142857 30.2 30 2 abnormal mitotic spindle morphology 2.64033063071223e-05 0.000259489098886414 0.962033462033462 0.857142857142857 30.2 30 2 abnormal interparietal bone morphology 0.00348519010927076 0.0170825820626818 0.962033462033462 0.857142857142857 30.2 30 2 amyloid beta deposits 0.00348519010927076 0.0170825820626818 0.962033462033462 0.857142857142857 30.2 30 2 absent olfactory bulb 0.00348519010927076 0.0170825820626818 0.962033462033462 0.857142857142857 30.2 30 2 abnormal vascular endothelial cell migration 0.00348519010927076 0.0170825820626818 0.962033462033462 0.857142857142857 30.2 30 2 vascular smooth muscle hypoplasia 0.00348519010927076 0.0170825820626818 0.962033462033462 0.857142857142857 30.2 30 2 abnormal maternal decidual layer morphology 0.00348519010927076 0.0170825820626818 0.962033462033462 0.857142857142857 30.2 30 2 lysosomal protein accumulation 0.00348519010927076 0.0170825820626818 0.962033462033462 0.857142857142857 30.2 30 2 abnormal iris pigmentation 0.00348519010927076 0.0170825820626818 0.962033462033462 0.857142857142857 30.2 30 2 abnormal viscerocranium morphology 0.00348519010927076 0.0170825820626818 0.962033462033462 0.857142857142857 30.2 30 2 decreased cornea thickness 0.00348519010927076 0.0170825820626818 0.962033462033462 0.857142857142857 30.2 30 2 decreased tongue size 0.00348519010927076 0.0170825820626818 0.962033462033462 0.857142857142857 30.2 30 2 increased lung compliance 0.00348519010927076 0.0170825820626818 0.962033462033462 0.857142857142857 30.2 30 2 pulmonary alveolar hemorrhage 0.00348519010927076 0.0170825820626818 0.962033462033462 0.857142857142857 30.2 30 2 testis degeneration 0.00348519010927076 0.0170825820626818 0.962033462033462 0.857142857142857 30.2 30 2 multiple persisting craniopharyngeal ducts 0.00348519010927076 0.0170825820626818 0.962033462033462 0.857142857142857 30.2 30 2 asymmetric rib joints 0.0456414165617493 0.132400027635395 0.962033462033462 0.857142857142857 30.2 30 2 cellular necrosis 0.0456414165617493 0.132400027635395 0.962033462033462 0.857142857142857 30.2 30 2 maxilla hypoplasia 0.0456414165617493 0.132400027635395 0.962033462033462 0.857142857142857 30.2 30 2 abnormal oculomotor nerve morphology 0.0456414165617493 0.132400027635395 0.962033462033462 0.857142857142857 30.2 30 2 decreased Schwann cell number 0.0456414165617493 0.132400027635395 0.962033462033462 0.857142857142857 30.2 30 2 prostate gland epithelial hyperplasia 0.0456414165617493 0.132400027635395 0.962033462033462 0.857142857142857 30.2 30 2 absent epidermis stratum corneum 0.0456414165617493 0.132400027635395 0.962033462033462 0.857142857142857 30.2 30 2 abnormal lacrimal gland morphology 0.0456414165617493 0.132400027635395 0.962033462033462 0.857142857142857 30.2 30 2 abnormal circulating free fatty acids level 0.0456414165617493 0.132400027635395 0.962033462033462 0.857142857142857 30.2 30 2 abnormal axial mesoderm 0.0456414165617493 0.132400027635395 0.962033462033462 0.857142857142857 30.2 30 2 decreased activated T cell number 0.0456414165617493 0.132400027635395 0.962033462033462 0.857142857142857 30.2 30 2 abnormal gastrulation movements 0.0456414165617493 0.132400027635395 0.962033462033462 0.857142857142857 30.2 30 2 abnormal lymph node primary follicle morphology 0.0456414165617493 0.132400027635395 0.962033462033462 0.857142857142857 30.2 30 2 abnormal melanocyte morphology 0.0456414165617493 0.132400027635395 0.962033462033462 0.857142857142857 30.2 30 2 decreased urine calcium level 0.0456414165617493 0.132400027635395 0.962033462033462 0.857142857142857 30.2 30 2 decreased mortality induced by ionizing radiation 0.0456414165617493 0.132400027635395 0.962033462033462 0.857142857142857 30.2 30 2 abnormal superior semicircular canal morphology 0.0456414165617493 0.132400027635395 0.962033462033462 0.857142857142857 30.2 30 2 calcinosis 0.0456414165617493 0.132400027635395 0.962033462033462 0.857142857142857 30.2 30 2 increased muscle weight 0.0456414165617493 0.132400027635395 0.962033462033462 0.857142857142857 30.2 30 2 increased ectoderm apoptosis 0.0456414165617493 0.132400027635395 0.962033462033462 0.857142857142857 30.2 30 2 renal necrosis 0.0456414165617493 0.132400027635395 0.962033462033462 0.857142857142857 30.2 30 2 abnormal optic tract morphology 0.0456414165617493 0.132400027635395 0.962033462033462 0.857142857142857 30.2 30 2 abnormal vestibular saccular macula morphology 0.0456414165617493 0.132400027635395 0.962033462033462 0.857142857142857 30.2 30 2 absent deltoid tuberosity 0.0456414165617493 0.132400027635395 0.962033462033462 0.857142857142857 30.2 30 2 abnormal talus morphology 0.0456414165617493 0.132400027635395 0.962033462033462 0.857142857142857 30.2 30 2 absent fibula 0.0456414165617493 0.132400027635395 0.962033462033462 0.857142857142857 30.2 30 2 abnormal body temperature 0.0456414165617493 0.132400027635395 0.962033462033462 0.857142857142857 30.2 30 2 retinal pigment epithelium atrophy 0.0456414165617493 0.132400027635395 0.962033462033462 0.857142857142857 30.2 30 2 decreased tidal volume 0.0456414165617493 0.132400027635395 0.962033462033462 0.857142857142857 30.2 30 2 uremia 0.0456414165617493 0.132400027635395 0.962033462033462 0.857142857142857 30.2 30 2 abnormal uterus physiology 0.0456414165617493 0.132400027635395 0.962033462033462 0.857142857142857 30.2 30 2 abnormal spinal cord central canal morphology 0.0456414165617493 0.132400027635395 0.962033462033462 0.857142857142857 30.2 30 2 heart hemorrhage 0.0456414165617493 0.132400027635395 0.962033462033462 0.857142857142857 30.2 30 2 abnormal prostaglandin level 0.0456414165617493 0.132400027635395 0.962033462033462 0.857142857142857 30.2 30 2 decreased DN2 thymocyte number 0.0456414165617493 0.132400027635395 0.962033462033462 0.857142857142857 30.2 30 2 arteritis 0.0456414165617493 0.132400027635395 0.962033462033462 0.857142857142857 30.2 30 2 increased oligodendrocyte number 0.0456414165617493 0.132400027635395 0.962033462033462 0.857142857142857 30.2 30 2 decreased brain cholesterol level 0.0456414165617493 0.132400027635395 0.962033462033462 0.857142857142857 30.2 30 2 decreased skeletal muscle glycogen level 0.0456414165617493 0.132400027635395 0.962033462033462 0.857142857142857 30.2 30 2 coronary fistula 0.0456414165617493 0.132400027635395 0.962033462033462 0.857142857142857 30.2 30 2 heart block 0.0456414165617493 0.132400027635395 0.962033462033462 0.857142857142857 30.2 30 2 abnormal aortic valve cusp morphology 0.0456414165617493 0.132400027635395 0.962033462033462 0.857142857142857 30.2 30 2 abnormal impulsive behavior control 0.0456414165617493 0.132400027635395 0.962033462033462 0.857142857142857 30.2 30 2 increased right ventricle systolic pressure 0.0456414165617493 0.132400027635395 0.962033462033462 0.857142857142857 30.2 30 2 increased compact bone volume 0.0456414165617493 0.132400027635395 0.962033462033462 0.857142857142857 30.2 30 2 small lung lobe 0.0456414165617493 0.132400027635395 0.962033462033462 0.857142857142857 30.2 30 2 abnormal outer hair cell kinocilium morphology 0.0456414165617493 0.132400027635395 0.962033462033462 0.857142857142857 30.2 30 2 embryonic lethality at implantation, incomplete penetrance 0.0456414165617493 0.132400027635395 0.962033462033462 0.857142857142857 30.2 30 2 small tail bud 0.0456414165617493 0.132400027635395 0.962033462033462 0.857142857142857 30.2 30 2 absent heart tube 0.0456414165617493 0.132400027635395 0.962033462033462 0.857142857142857 30.2 30 2 decreased CD8-positive, naive alpha-beta T cell number 0.0456414165617493 0.132400027635395 0.962033462033462 0.857142857142857 30.2 30 2 abnormal Mullerian duct topology 0.0456414165617493 0.132400027635395 0.962033462033462 0.857142857142857 30.2 30 2 abnormal eye morphology 2.63566701754453e-21 2.9138763138409e-19 0.960879944692894 0.856115107913669 30.2 30 2 embryonic lethality before implantation, complete penetrance 2.74976097065347e-19 2.53334459796315e-17 0.960750750750751 0.856 30.2 30 2 decreased spleen weight 3.41003510678037e-11 1.28522156486609e-09 0.95970970970971 0.855072463768116 30.2 30 2 lethality throughout fetal growth and development, incomplete penetrance 7.7846906762178e-27 1.8442302911516e-24 0.959346217726106 0.854748603351955 30.2 30 2 thymus atrophy 3.88919970933419e-08 8.30419251241957e-07 0.958693068068068 0.854166666666667 30.2 30 2 decreased rib number 5.65859764711773e-14 3.1279470327123e-12 0.958430340452812 0.853932584269663 30.2 30 2 thick ventricular wall 4.12412365501106e-07 6.83917172789334e-06 0.958122756903245 0.853658536585366 30.2 30 2 palatal shelves fail to meet at midline 4.12412365501106e-07 6.83917172789334e-06 0.958122756903245 0.853658536585366 30.2 30 2 overexpanded pulmonary alveoli 4.42675523405502e-06 5.4033529607359e-05 0.957317611729376 0.852941176470588 30.2 30 2 abnormal endoderm development 4.42675523405502e-06 5.4033529607359e-05 0.957317611729376 0.852941176470588 30.2 30 2 abnormal nervous system development 4.42675523405502e-06 5.4033529607359e-05 0.957317611729376 0.852941176470588 30.2 30 2 increased osteoclast cell number 6.45781968282648e-10 1.98318845197912e-08 0.956776448579727 0.852459016393443 30.2 30 2 abnormal eye muscle morphology 4.8365645270853e-05 0.0004490861246969 0.956094983872762 0.851851851851852 30.2 30 2 neuron degeneration 7.08670008185185e-08 1.42738189907745e-06 0.955210529678615 0.851063829787234 30.2 30 2 increased respiratory quotient 7.08670008185185e-08 1.42738189907745e-06 0.955210529678615 0.851063829787234 30.2 30 2 intracranial hemorrhage 1.17385358746394e-09 3.37567722406538e-08 0.954016516516517 0.85 30.2 30 2 abnormal vascular regression 0.000543349458330162 0.00365292372323319 0.954016516516517 0.85 30.2 30 2 abnormal optic stalk morphology 0.000543349458330162 0.00365292372323319 0.954016516516517 0.85 30.2 30 2 increased skin tumor incidence 0.000543349458330162 0.00365292372323319 0.954016516516517 0.85 30.2 30 2 astrocytosis 1.98331775165896e-11 7.76929591693176e-10 0.953247768316261 0.849315068493151 30.2 30 2 abnormal mesoderm development 1.22507799510991e-08 2.93017453157299e-07 0.952957674655788 0.849056603773585 30.2 30 2 single kidney 8.06419932576505e-06 9.20169533157824e-05 0.952315952315952 0.848484848484849 30.2 30 2 abnormal QRS complex 8.06419932576505e-06 9.20169533157824e-05 0.952315952315952 0.848484848484849 30.2 30 2 abnormal erythropoiesis 1.03633474618561e-15 7.06269227708686e-14 0.951344201344202 0.847619047619048 30.2 30 2 distended pericardium 2.2188098084184e-08 4.95003533492447e-07 0.9496996996997 0.846153846153846 30.2 30 2 kinked neural tube 2.2188098084184e-08 4.95003533492447e-07 0.9496996996997 0.846153846153846 30.2 30 2 abnormal iris morphology 1.36343367648111e-06 1.89471579343394e-05 0.9496996996997 0.846153846153846 30.2 30 2 abnormal nasal bone morphology 8.80954672290973e-05 0.000755646464594412 0.9496996996997 0.846153846153846 30.2 30 2 abnormal ureter morphology 8.80954672290973e-05 0.000755646464594412 0.9496996996997 0.846153846153846 30.2 30 2 abnormal Mullerian duct morphology 8.80954672290973e-05 0.000755646464594412 0.9496996996997 0.846153846153846 30.2 30 2 absent teeth 0.00641339278522274 0.0283469885476634 0.9496996996997 0.846153846153846 30.2 30 2 excessive scratching 0.00641339278522274 0.0283469885476634 0.9496996996997 0.846153846153846 30.2 30 2 abnormal pulmonary alveolus epithelial cell morphology 0.00641339278522274 0.0283469885476634 0.9496996996997 0.846153846153846 30.2 30 2 abnormal tail bud morphology 0.00641339278522274 0.0283469885476634 0.9496996996997 0.846153846153846 30.2 30 2 increased synaptic depression 0.00641339278522274 0.0283469885476634 0.9496996996997 0.846153846153846 30.2 30 2 absent lateral semicircular canal 0.00641339278522274 0.0283469885476634 0.9496996996997 0.846153846153846 30.2 30 2 abnormal insulin secretion 0.00641339278522274 0.0283469885476634 0.9496996996997 0.846153846153846 30.2 30 2 empty decidua capsularis 0.00641339278522274 0.0283469885476634 0.9496996996997 0.846153846153846 30.2 30 2 increased prostaglandin level 0.00641339278522274 0.0283469885476634 0.9496996996997 0.846153846153846 30.2 30 2 abnormal aorta tunica media morphology 0.00641339278522274 0.0283469885476634 0.9496996996997 0.846153846153846 30.2 30 2 decreased cardiac stroke volume 0.00641339278522274 0.0283469885476634 0.9496996996997 0.846153846153846 30.2 30 2 decreased liver weight 6.4874513620183e-11 2.32194751985907e-09 0.948483694962568 0.845070422535211 30.2 30 2 scoliosis 1.46192123170048e-05 0.000157085488719436 0.947001689189189 0.84375 30.2 30 2 increased fatty acid level 1.46192123170048e-05 0.000157085488719436 0.947001689189189 0.84375 30.2 30 2 abnormal embryonic tissue morphology 5.72094803325856e-21 6.18732966640464e-19 0.946763089620232 0.843537414965986 30.2 30 2 abnormal gastrulation 4.00547758712277e-08 8.37279453610748e-07 0.946313961019843 0.843137254901961 30.2 30 2 embryonic lethality between somite formation and embryo turning, complete penetrance 1.16901434973432e-10 3.92962593914069e-09 0.945999570999571 0.842857142857143 30.2 30 2 abnormal craniofacial bone morphology 6.9304496977528e-09 1.70688055674852e-07 0.945155681997787 0.842105263157895 30.2 30 2 abnormal frontal bone morphology 2.46352616368215e-06 3.27701675516542e-05 0.945155681997787 0.842105263157895 30.2 30 2 decreased total retina thickness 2.46352616368215e-06 3.27701675516542e-05 0.945155681997787 0.842105263157895 30.2 30 2 altered susceptibility to infection 0.000989484191912664 0.00617651675629298 0.945155681997787 0.842105263157895 30.2 30 2 abnormal nasal septum morphology 0.000989484191912664 0.00617651675629298 0.945155681997787 0.842105263157895 30.2 30 2 abnormal metatarsal bone morphology 0.000989484191912664 0.00617651675629298 0.945155681997787 0.842105263157895 30.2 30 2 increased liver adenoma incidence 0.000989484191912664 0.00617651675629298 0.945155681997787 0.842105263157895 30.2 30 2 decreased fertilization frequency 0.000989484191912664 0.00617651675629298 0.945155681997787 0.842105263157895 30.2 30 2 increased liver cholesterol level 0.000989484191912664 0.00617651675629298 0.945155681997787 0.842105263157895 30.2 30 2 double outlet right ventricle 1.9318059410414e-15 1.26457033640539e-13 0.944051528163678 0.841121495327103 30.2 30 2 muscular atrophy 4.19656545512099e-07 6.92098234290379e-06 0.943813131313131 0.840909090909091 30.2 30 2 abnormal embryo size 3.41524175215392e-16 2.46243879956025e-14 0.943587392702437 0.84070796460177 30.2 30 2 abnormal sternum morphology 2.1011634350941e-10 6.87716321683761e-09 0.943443443443443 0.840579710144927 30.2 30 2 abnormal interventricular septum morphology 7.20623634217639e-08 1.44560587912611e-06 0.942792792792793 0.84 30.2 30 2 abnormal cochlear outer hair cell morphology 0.000159483516285551 0.00128029021434025 0.942792792792793 0.84 30.2 30 2 osteopetrosis 2.63656473105731e-05 0.000259489098886414 0.941344570376829 0.838709677419355 30.2 30 2 abnormal podocyte morphology 2.63656473105731e-05 0.000259489098886414 0.941344570376829 0.838709677419355 30.2 30 2 decreased circulating chloride level 4.43129247835226e-06 5.4033529607359e-05 0.940366041717393 0.837837837837838 30.2 30 2 increased erythroid progenitor cell number 4.43129247835226e-06 5.4033529607359e-05 0.940366041717393 0.837837837837838 30.2 30 2 abnormal vasculogenesis 7.53416963533279e-07 1.13583314956911e-05 0.939660590823381 0.837209302325581 30.2 30 2 decreased oxygen consumption 7.53416963533279e-07 1.13583314956911e-05 0.939660590823381 0.837209302325581 30.2 30 2 polydactyly 6.28284179957499e-14 3.43485032449292e-12 0.939127903413618 0.836734693877551 30.2 30 2 rib fusion 6.73421463665095e-10 2.05538146118641e-08 0.938102281385863 0.835820895522388 30.2 30 2 abnormal visceral yolk sac morphology 2.06098972461578e-11 7.94839060462287e-10 0.937678184513627 0.835443037974684 30.2 30 2 abnormal nervous system morphology 2.06098972461578e-11 7.94839060462287e-10 0.937678184513627 0.835443037974684 30.2 30 2 abnormal cell cycle 6.16877392244847e-16 4.38423575202588e-14 0.936936936936937 0.834782608695652 30.2 30 2 narrow eye opening 7.9331383430884e-06 9.09386250158175e-05 0.935310310310311 0.833333333333333 30.2 30 2 lowered ear position 0.00178714535210078 0.0100237295678708 0.935310310310311 0.833333333333333 30.2 30 2 abnormal mitral valve morphology 0.00178714535210078 0.0100237295678708 0.935310310310311 0.833333333333333 30.2 30 2 abnormal stomach glandular epithelium morphology 0.00178714535210078 0.0100237295678708 0.935310310310311 0.833333333333333 30.2 30 2 cortical renal glomerulopathies 0.00178714535210078 0.0100237295678708 0.935310310310311 0.833333333333333 30.2 30 2 abnormal radius morphology 0.00178714535210078 0.0100237295678708 0.935310310310311 0.833333333333333 30.2 30 2 eye inflammation 0.00178714535210078 0.0100237295678708 0.935310310310311 0.833333333333333 30.2 30 2 abnormal thyroid cartilage morphology 0.00178714535210078 0.0100237295678708 0.935310310310311 0.833333333333333 30.2 30 2 absent inner cell mass 0.00178714535210078 0.0100237295678708 0.935310310310311 0.833333333333333 30.2 30 2 abnormal glycogen homeostasis 0.00178714535210078 0.0100237295678708 0.935310310310311 0.833333333333333 30.2 30 2 decreased pulmonary respiratory rate 0.00178714535210078 0.0100237295678708 0.935310310310311 0.833333333333333 30.2 30 2 increased effector memory CD4-positive, alpha-beta T cell number 0.00178714535210078 0.0100237295678708 0.935310310310311 0.833333333333333 30.2 30 2 increased adipocyte glucose uptake 0.00178714535210078 0.0100237295678708 0.935310310310311 0.833333333333333 30.2 30 2 abnormal heart tube morphology 4.72885565238239e-05 0.000440562862745363 0.93531031031031 0.833333333333333 30.2 30 2 abnormal lactation 4.72885565238239e-05 0.000440562862745363 0.93531031031031 0.833333333333333 30.2 30 2 enhanced paired-pulse facilitation 4.72885565238239e-05 0.000440562862745363 0.93531031031031 0.833333333333333 30.2 30 2 abnormal microglial cell physiology 4.72885565238239e-05 0.000440562862745363 0.93531031031031 0.833333333333333 30.2 30 2 abnormal fat pad morphology 4.72885565238239e-05 0.000440562862745363 0.93531031031031 0.833333333333333 30.2 30 2 abnormal chondrocyte morphology 3.97907112105275e-08 8.35269148828583e-07 0.93531031031031 0.833333333333333 30.2 30 2 abnormal maxilla morphology 3.97907112105275e-08 8.35269148828583e-07 0.93531031031031 0.833333333333333 30.2 30 2 abnormal apoptosis 3.97907112105275e-08 8.35269148828583e-07 0.93531031031031 0.833333333333333 30.2 30 2 neurodegeneration 3.97907112105275e-08 8.35269148828583e-07 0.93531031031031 0.833333333333333 30.2 30 2 abnormal osteoblast morphology 0.000286819153905844 0.00211709983780649 0.93531031031031 0.833333333333333 30.2 30 2 abnormal mineral level 0.0116732915167494 0.0457640861275241 0.93531031031031 0.833333333333333 30.2 30 2 amyloidosis 0.0116732915167494 0.0457640861275241 0.93531031031031 0.833333333333333 30.2 30 2 absent optic nerve 0.0116732915167494 0.0457640861275241 0.93531031031031 0.833333333333333 30.2 30 2 interstitial pneumonia 0.0116732915167494 0.0457640861275241 0.93531031031031 0.833333333333333 30.2 30 2 abnormal embryonic growth/weight/body size 0.0116732915167494 0.0457640861275241 0.93531031031031 0.833333333333333 30.2 30 2 abnormal tracheal ciliated epithelium morphology 0.0116732915167494 0.0457640861275241 0.93531031031031 0.833333333333333 30.2 30 2 decreased synaptic depression 0.0116732915167494 0.0457640861275241 0.93531031031031 0.833333333333333 30.2 30 2 abnormal aorta elastic fiber morphology 0.0116732915167494 0.0457640861275241 0.93531031031031 0.833333333333333 30.2 30 2 abnormal alisphenoid bone morphology 0.0116732915167494 0.0457640861275241 0.93531031031031 0.833333333333333 30.2 30 2 dilated bile duct 0.0116732915167494 0.0457640861275241 0.93531031031031 0.833333333333333 30.2 30 2 abnormal fatty acid level 0.0116732915167494 0.0457640861275241 0.93531031031031 0.833333333333333 30.2 30 2 reduced cerebellar foliation 0.0116732915167494 0.0457640861275241 0.93531031031031 0.833333333333333 30.2 30 2 abnormal vitelline vein connection 0.0116732915167494 0.0457640861275241 0.93531031031031 0.833333333333333 30.2 30 2 abnormal ear shape 0.0846039348534437 0.203729223570127 0.93531031031031 0.833333333333333 30.2 30 2 large anterior fontanelle 0.0846039348534437 0.203729223570127 0.93531031031031 0.833333333333333 30.2 30 2 arrest of tooth development 0.0846039348534437 0.203729223570127 0.93531031031031 0.833333333333333 30.2 30 2 echinocytosis 0.0846039348534437 0.203729223570127 0.93531031031031 0.833333333333333 30.2 30 2 abnormal urethra morphology 0.0846039348534437 0.203729223570127 0.93531031031031 0.833333333333333 30.2 30 2 constricted vagina orifice 0.0846039348534437 0.203729223570127 0.93531031031031 0.833333333333333 30.2 30 2 epidermal necrosis 0.0846039348534437 0.203729223570127 0.93531031031031 0.833333333333333 30.2 30 2 abnormal lens induction 0.0846039348534437 0.203729223570127 0.93531031031031 0.833333333333333 30.2 30 2 jumpy 0.0846039348534437 0.203729223570127 0.93531031031031 0.833333333333333 30.2 30 2 increased embryo size 0.0846039348534437 0.203729223570127 0.93531031031031 0.833333333333333 30.2 30 2 absent ectoplacental cone 0.0846039348534437 0.203729223570127 0.93531031031031 0.833333333333333 30.2 30 2 delayed brain development 0.0846039348534437 0.203729223570127 0.93531031031031 0.833333333333333 30.2 30 2 abnormal gustatory system physiology 0.0846039348534437 0.203729223570127 0.93531031031031 0.833333333333333 30.2 30 2 abnormal parental behavior 0.0846039348534437 0.203729223570127 0.93531031031031 0.833333333333333 30.2 30 2 abnormal gland physiology 0.0846039348534437 0.203729223570127 0.93531031031031 0.833333333333333 30.2 30 2 abnormal pulmonary ventilation 0.0846039348534437 0.203729223570127 0.93531031031031 0.833333333333333 30.2 30 2 chromatolysis 0.0846039348534437 0.203729223570127 0.93531031031031 0.833333333333333 30.2 30 2 abnormal otolithic membrane morphology 0.0846039348534437 0.203729223570127 0.93531031031031 0.833333333333333 30.2 30 2 increased post-tetanic potentiation 0.0846039348534437 0.203729223570127 0.93531031031031 0.833333333333333 30.2 30 2 abnormal sebaceous lipid secretion 0.0846039348534437 0.203729223570127 0.93531031031031 0.833333333333333 30.2 30 2 ectopic thymus 0.0846039348534437 0.203729223570127 0.93531031031031 0.833333333333333 30.2 30 2 liver cirrhosis 0.0846039348534437 0.203729223570127 0.93531031031031 0.833333333333333 30.2 30 2 absent cochlea 0.0846039348534437 0.203729223570127 0.93531031031031 0.833333333333333 30.2 30 2 decreased posterior semicircular canal size 0.0846039348534437 0.203729223570127 0.93531031031031 0.833333333333333 30.2 30 2 extremity edema 0.0846039348534437 0.203729223570127 0.93531031031031 0.833333333333333 30.2 30 2 abnormal intestinal peristalsis 0.0846039348534437 0.203729223570127 0.93531031031031 0.833333333333333 30.2 30 2 decreased liver function 0.0846039348534437 0.203729223570127 0.93531031031031 0.833333333333333 30.2 30 2 pancreas fibrosis 0.0846039348534437 0.203729223570127 0.93531031031031 0.833333333333333 30.2 30 2 abnormal zona pellucida morphology 0.0846039348534437 0.203729223570127 0.93531031031031 0.833333333333333 30.2 30 2 abnormal lambdoidal suture morphology 0.0846039348534437 0.203729223570127 0.93531031031031 0.833333333333333 30.2 30 2 matted coat 0.0846039348534437 0.203729223570127 0.93531031031031 0.833333333333333 30.2 30 2 abnormal cholesterol level 0.0846039348534437 0.203729223570127 0.93531031031031 0.833333333333333 30.2 30 2 abnormal extensor digitorum longus morphology 0.0846039348534437 0.203729223570127 0.93531031031031 0.833333333333333 30.2 30 2 abnormal physical strength 0.0846039348534437 0.203729223570127 0.93531031031031 0.833333333333333 30.2 30 2 absent incus 0.0846039348534437 0.203729223570127 0.93531031031031 0.833333333333333 30.2 30 2 short scapula 0.0846039348534437 0.203729223570127 0.93531031031031 0.833333333333333 30.2 30 2 abnormal strial intermediate cell morphology 0.0846039348534437 0.203729223570127 0.93531031031031 0.833333333333333 30.2 30 2 enlarged interparietal bone 0.0846039348534437 0.203729223570127 0.93531031031031 0.833333333333333 30.2 30 2 absent cochlear nerve compound action potential 0.0846039348534437 0.203729223570127 0.93531031031031 0.833333333333333 30.2 30 2 abnormal common crus morphology 0.0846039348534437 0.203729223570127 0.93531031031031 0.833333333333333 30.2 30 2 decreased prostate gland weight 0.0846039348534437 0.203729223570127 0.93531031031031 0.833333333333333 30.2 30 2 abnormal blastocoele morphology 0.0846039348534437 0.203729223570127 0.93531031031031 0.833333333333333 30.2 30 2 osteomyelitis 0.0846039348534437 0.203729223570127 0.93531031031031 0.833333333333333 30.2 30 2 variegated coat color 0.0846039348534437 0.203729223570127 0.93531031031031 0.833333333333333 30.2 30 2 abnormal ligament morphology 0.0846039348534437 0.203729223570127 0.93531031031031 0.833333333333333 30.2 30 2 abnormal dermis papillary layer morphology 0.0846039348534437 0.203729223570127 0.93531031031031 0.833333333333333 30.2 30 2 decreased platelet ADP level 0.0846039348534437 0.203729223570127 0.93531031031031 0.833333333333333 30.2 30 2 delayed chorioallantoic fusion 0.0846039348534437 0.203729223570127 0.93531031031031 0.833333333333333 30.2 30 2 increased urine uric acid level 0.0846039348534437 0.203729223570127 0.93531031031031 0.833333333333333 30.2 30 2 abnormal thromboxane level 0.0846039348534437 0.203729223570127 0.93531031031031 0.833333333333333 30.2 30 2 abnormal neural crest cell morphology 0.0846039348534437 0.203729223570127 0.93531031031031 0.833333333333333 30.2 30 2 exostosis 0.0846039348534437 0.203729223570127 0.93531031031031 0.833333333333333 30.2 30 2 ectopic hippocampus pyramidal cells 0.0846039348534437 0.203729223570127 0.93531031031031 0.833333333333333 30.2 30 2 abnormal oval cell physiology 0.0846039348534437 0.203729223570127 0.93531031031031 0.833333333333333 30.2 30 2 abnormal synaptic dopamine release 0.0846039348534437 0.203729223570127 0.93531031031031 0.833333333333333 30.2 30 2 enlarged lymphatic vessel 0.0846039348534437 0.203729223570127 0.93531031031031 0.833333333333333 30.2 30 2 abnormal acute phase protein level 0.0846039348534437 0.203729223570127 0.93531031031031 0.833333333333333 30.2 30 2 abnormal epiglottis morphology 0.0846039348534437 0.203729223570127 0.93531031031031 0.833333333333333 30.2 30 2 abnormal pharyngeal arch development 0.0846039348534437 0.203729223570127 0.93531031031031 0.833333333333333 30.2 30 2 abnormal heart right ventricle outflow tract morphology 0.0846039348534437 0.203729223570127 0.93531031031031 0.833333333333333 30.2 30 2 kidney microaneurysm 0.0846039348534437 0.203729223570127 0.93531031031031 0.833333333333333 30.2 30 2 cerebral arteriovenous malformation 0.0846039348534437 0.203729223570127 0.93531031031031 0.833333333333333 30.2 30 2 common truncal valve 0.0846039348534437 0.203729223570127 0.93531031031031 0.833333333333333 30.2 30 2 persistent hyperplastic primary vitreous 0.0846039348534437 0.203729223570127 0.93531031031031 0.833333333333333 30.2 30 2 abnormal mandibular prominence morphology 0.0846039348534437 0.203729223570127 0.93531031031031 0.833333333333333 30.2 30 2 abnormal ureteric bud elongation 0.0846039348534437 0.203729223570127 0.93531031031031 0.833333333333333 30.2 30 2 decreased macrophage nitric oxide production 0.0846039348534437 0.203729223570127 0.93531031031031 0.833333333333333 30.2 30 2 abnormal ureteric bud tip morphology 0.0846039348534437 0.203729223570127 0.93531031031031 0.833333333333333 30.2 30 2 podocyte hypertrophy 0.0846039348534437 0.203729223570127 0.93531031031031 0.833333333333333 30.2 30 2 abnormal endocrine pancreas development 0.0846039348534437 0.203729223570127 0.93531031031031 0.833333333333333 30.2 30 2 absent midbrain 0.0846039348534437 0.203729223570127 0.93531031031031 0.833333333333333 30.2 30 2 absent thymus corticomedullary boundary 0.0846039348534437 0.203729223570127 0.93531031031031 0.833333333333333 30.2 30 2 ciliary body hypoplasia 0.0846039348534437 0.203729223570127 0.93531031031031 0.833333333333333 30.2 30 2 additional anastomosis between intracranial vertebral arteries 0.0846039348534437 0.203729223570127 0.93531031031031 0.833333333333333 30.2 30 2 increased male germ cell apoptosis 0.0846039348534437 0.203729223570127 0.93531031031031 0.833333333333333 30.2 30 2 increased body fat mass 0.0846039348534437 0.203729223570127 0.93531031031031 0.833333333333333 30.2 30 2 ectopic bone 0.0846039348534437 0.203729223570127 0.93531031031031 0.833333333333333 30.2 30 2 decreased hippocampus volume 0.0846039348534437 0.203729223570127 0.93531031031031 0.833333333333333 30.2 30 2 decreased tear production 0.0846039348534437 0.203729223570127 0.93531031031031 0.833333333333333 30.2 30 2 abnormal excitatory synapse morphology 0.0846039348534437 0.203729223570127 0.93531031031031 0.833333333333333 30.2 30 2 embryonic lethality between implantation and somite formation, complete penetrance 5.71580198098671e-32 2.18739345041607e-29 0.934546791689649 0.83265306122449 30.2 30 2 abnormal brain morphology 1.89145085790558e-21 2.24046857573339e-19 0.934148434148434 0.832298136645963 30.2 30 2 anophthalmia 2.01395936031109e-12 8.56363061328862e-11 0.933208489388265 0.831460674157303 30.2 30 2 perinatal lethality, complete penetrance 1.03493600637323e-27 2.70989822721411e-25 0.932675633379859 0.830985915492958 30.2 30 2 abnormal coat/hair pigmentation 3.46168176501546e-15 2.20793163858358e-13 0.931969916344916 0.830357142857143 30.2 30 2 abnormal tibia morphology 4.1054000213486e-07 6.83917172789334e-06 0.931330266436649 0.829787234042553 30.2 30 2 hemopericardium 2.3978106847265e-06 3.20674950443934e-05 0.930747820991724 0.829268292682927 30.2 30 2 abnormal axial skeleton morphology 1.15693945255894e-10 3.91549236495288e-09 0.930387624466572 0.828947368421053 30.2 30 2 abnormal embryonic epiblast morphology 1.41313287047397e-05 0.00015283339196974 0.92996567996568 0.828571428571429 30.2 30 2 decreased bone volume 1.41313287047397e-05 0.00015283339196974 0.92996567996568 0.828571428571429 30.2 30 2 lethargy 1.11304581733103e-12 5.08018618460721e-11 0.929276050243792 0.827956989247312 30.2 30 2 short sternum 8.43165998025376e-05 0.000732068209454842 0.928859894377136 0.827586206896552 30.2 30 2 abnormal placenta vasculature 1.25417791964881e-07 2.41842447684217e-06 0.928115615615616 0.826923076923077 30.2 30 2 ataxia 1.01519891496718e-25 2.19591939215728e-23 0.927901911812803 0.826732673267327 30.2 30 2 abnormal vitelline vasculature morphology 3.38399059330917e-15 2.18640950671599e-13 0.927177177177177 0.826086956521739 30.2 30 2 bidirectional circling 0.000512139026300035 0.00353873841089261 0.927177177177177 0.826086956521739 30.2 30 2 abnormal nasal cavity morphology 0.000512139026300035 0.00353873841089261 0.927177177177177 0.826086956521739 30.2 30 2 abnormal cardiovascular development 0.000512139026300035 0.00353873841089261 0.927177177177177 0.826086956521739 30.2 30 2 abnormal corneal stroma morphology 0.000512139026300035 0.00353873841089261 0.927177177177177 0.826086956521739 30.2 30 2 abnormal hematopoietic stem cell physiology 0.000512139026300035 0.00353873841089261 0.927177177177177 0.826086956521739 30.2 30 2 microcephaly 1.16779754656167e-09 3.37567722406538e-08 0.927177177177177 0.826086956521739 30.2 30 2 perimembraneous ventricular septal defect 1.16779754656167e-09 3.37567722406538e-08 0.927177177177177 0.826086956521739 30.2 30 2 abnormal craniofacial morphology 1.08058575814061e-13 5.71905760292504e-12 0.926229627685938 0.825242718446602 30.2 30 2 embryonic lethality during organogenesis, complete penetrance 2.43557611301543e-68 2.42339823245035e-65 0.925957207207207 0.825 30.2 30 2 abnormal myocardial fiber morphology 6.11380400046097e-13 2.92463220214359e-11 0.925667935977214 0.824742268041237 30.2 30 2 decreased embryo size 3.32889041989278e-58 2.36588997699522e-55 0.925135386432458 0.824267782426778 30.2 30 2 abnormal bone marrow cavity morphology 0.00319841123069283 0.0161872796263447 0.924306659600777 0.823529411764706 30.2 30 2 abnormal interatrial septum morphology 0.00319841123069283 0.0161872796263447 0.924306659600777 0.823529411764706 30.2 30 2 abnormal dorsal-ventral axis patterning 0.00319841123069283 0.0161872796263447 0.924306659600777 0.823529411764706 30.2 30 2 abnormal duodenum morphology 0.00319841123069283 0.0161872796263447 0.924306659600777 0.823529411764706 30.2 30 2 aminoaciduria 0.00319841123069283 0.0161872796263447 0.924306659600777 0.823529411764706 30.2 30 2 abnormal embryonic-extraembryonic boundary morphology 0.00319841123069283 0.0161872796263447 0.924306659600777 0.823529411764706 30.2 30 2 increased brain size 0.00319841123069283 0.0161872796263447 0.924306659600777 0.823529411764706 30.2 30 2 enhanced behavioral response to cocaine 0.00319841123069283 0.0161872796263447 0.924306659600777 0.823529411764706 30.2 30 2 increased hepatoma incidence 0.00319841123069283 0.0161872796263447 0.924306659600777 0.823529411764706 30.2 30 2 abnormal ductus venosus valve morphology 0.00319841123069283 0.0161872796263447 0.924306659600777 0.823529411764706 30.2 30 2 abnormal cell cytoskeleton morphology 0.00319841123069283 0.0161872796263447 0.924306659600777 0.823529411764706 30.2 30 2 abnormal response to novel object 2.21431105324265e-07 3.96266096758353e-06 0.924306659600777 0.823529411764706 30.2 30 2 abnormal placenta morphology 1.11515463188409e-10 3.82613399560231e-09 0.923470939293724 0.822784810126582 30.2 30 2 prenatal lethality 1.17748067431566e-08 2.82993543706299e-07 0.923241790177274 0.82258064516129 30.2 30 2 trabecula carnea hypoplasia 1.28374926411628e-06 1.79905706731789e-05 0.922839506172839 0.822222222222222 30.2 30 2 abnormal ectoderm development 1.28374926411628e-06 1.79905706731789e-05 0.922839506172839 0.822222222222222 30.2 30 2 decreased cell proliferation 5.43255033562841e-23 7.94909938816216e-21 0.922165408651895 0.821621621621622 30.2 30 2 failure of blastocyst to hatch from the zona pellucida 0.000149392404504015 0.00120849953236988 0.921948734448734 0.821428571428571 30.2 30 2 abnormal hormone level 0.000149392404504015 0.00120849953236988 0.921948734448734 0.821428571428571 30.2 30 2 increased bone resorption 0.000149392404504015 0.00120849953236988 0.921948734448734 0.821428571428571 30.2 30 2 abnormal response to injury 7.49252039088691e-06 8.72957586526051e-05 0.920920920920921 0.82051282051282 30.2 30 2 short stride length 3.89425266464185e-07 6.56742610392989e-06 0.920345345345345 0.82 30.2 30 2 increased B cell derived lymphoma incidence 3.89425266464185e-07 6.56742610392989e-06 0.920345345345345 0.82 30.2 30 2 abnormal long bone morphology 2.0672681050981e-08 4.71773340498304e-07 0.919977354403584 0.819672131147541 30.2 30 2 abnormal digit morphology 1.1125588019826e-09 3.25587061168438e-08 0.919721805138472 0.819444444444444 30.2 30 2 pale yolk sac 6.04411790047915e-11 2.1948530332032e-09 0.919533991823148 0.819277108433735 30.2 30 2 abnormal neural tube closure 6.04411790047915e-11 2.1948530332032e-09 0.919533991823148 0.819277108433735 30.2 30 2 cleft secondary palate 3.30555340299467e-12 1.37042734832487e-10 0.919390134815667 0.819148936170213 30.2 30 2 small kidney 1.86777796852247e-11 7.3747582487296e-10 0.918304668304668 0.818181818181818 30.2 30 2 omphalocele 2.25533884462859e-06 3.03251641946682e-05 0.918304668304668 0.818181818181818 30.2 30 2 enlarged pericardium 4.41167707775838e-05 0.000418058923082818 0.918304668304668 0.818181818181818 30.2 30 2 dextrocardia 4.41167707775838e-05 0.000418058923082818 0.918304668304668 0.818181818181818 30.2 30 2 testis hypoplasia 0.000907361512361928 0.0057578106173477 0.918304668304668 0.818181818181818 30.2 30 2 abnormal chorion morphology 0.000907361512361928 0.0057578106173477 0.918304668304668 0.818181818181818 30.2 30 2 abnormal basement membrane morphology 0.000907361512361928 0.0057578106173477 0.918304668304668 0.818181818181818 30.2 30 2 failure of palatal shelf elevation 0.000907361512361928 0.0057578106173477 0.918304668304668 0.818181818181818 30.2 30 2 abnormal cerebral cortex pyramidal cell morphology 0.000907361512361928 0.0057578106173477 0.918304668304668 0.818181818181818 30.2 30 2 increased mammary gland tumor incidence 0.000907361512361928 0.0057578106173477 0.918304668304668 0.818181818181818 30.2 30 2 embryonic lethality before implantation, incomplete penetrance 0.000907361512361928 0.0057578106173477 0.918304668304668 0.818181818181818 30.2 30 2 abnormal awl hair morphology 0.0209781264559007 0.0748144653176386 0.918304668304668 0.818181818181818 30.2 30 2 abnormal enteric ganglia morphology 0.0209781264559007 0.0748144653176386 0.918304668304668 0.818181818181818 30.2 30 2 focal hepatic necrosis 0.0209781264559007 0.0748144653176386 0.918304668304668 0.818181818181818 30.2 30 2 abnormal fear/anxiety-related behavior 0.0209781264559007 0.0748144653176386 0.918304668304668 0.818181818181818 30.2 30 2 allodynia 0.0209781264559007 0.0748144653176386 0.918304668304668 0.818181818181818 30.2 30 2 loss of cortex neurons 0.0209781264559007 0.0748144653176386 0.918304668304668 0.818181818181818 30.2 30 2 impaired luteinization 0.0209781264559007 0.0748144653176386 0.918304668304668 0.818181818181818 30.2 30 2 dilated renal glomerular capsule 0.0209781264559007 0.0748144653176386 0.918304668304668 0.818181818181818 30.2 30 2 abnormal pituitary gland development 0.0209781264559007 0.0748144653176386 0.918304668304668 0.818181818181818 30.2 30 2 abnormal spinal cord ventral horn morphology 0.0209781264559007 0.0748144653176386 0.918304668304668 0.818181818181818 30.2 30 2 increased motor neuron number 0.0209781264559007 0.0748144653176386 0.918304668304668 0.818181818181818 30.2 30 2 abnormal dorsal-ventral polarity of the somites 0.0209781264559007 0.0748144653176386 0.918304668304668 0.818181818181818 30.2 30 2 abnormal platelet aggregation 0.0209781264559007 0.0748144653176386 0.918304668304668 0.818181818181818 30.2 30 2 abnormal superovulation 0.0209781264559007 0.0748144653176386 0.918304668304668 0.818181818181818 30.2 30 2 abnormal palatal shelf elevation 0.0209781264559007 0.0748144653176386 0.918304668304668 0.818181818181818 30.2 30 2 common atrioventricular valve 0.0209781264559007 0.0748144653176386 0.918304668304668 0.818181818181818 30.2 30 2 abnormal pulmonary alveolar sac morphology 0.0209781264559007 0.0748144653176386 0.918304668304668 0.818181818181818 30.2 30 2 increased pancreatic beta cell proliferation 0.0209781264559007 0.0748144653176386 0.918304668304668 0.818181818181818 30.2 30 2 decreased embryonic cilium length 0.0209781264559007 0.0748144653176386 0.918304668304668 0.818181818181818 30.2 30 2 thin hypoglossal nerve 0.0209781264559007 0.0748144653176386 0.918304668304668 0.818181818181818 30.2 30 2 cleft palate 3.0077875832635e-16 2.20055047451999e-14 0.916746899571327 0.816793893129771 30.2 30 2 increased erythrocyte cell number 3.6171542598449e-08 7.75661312186568e-07 0.916604104104104 0.816666666666667 30.2 30 2 absent kidney 6.8209461266664e-07 1.06044396813017e-05 0.916222344793773 0.816326530612245 30.2 30 2 abnormal craniofacial development 6.8209461266664e-07 1.06044396813017e-05 0.916222344793773 0.816326530612245 30.2 30 2 abnormal embryo development 9.34930886210304e-17 7.04739569529737e-15 0.916053921568628 0.816176470588235 30.2 30 2 ventricular septal defect 9.34930886210304e-17 7.04739569529737e-15 0.916053921568628 0.816176470588235 30.2 30 2 lethality throughout fetal growth and development, complete penetrance 8.62461945693943e-23 1.22592805137925e-20 0.915619566935356 0.815789473684211 30.2 30 2 decreased hair follicle number 1.31456861576056e-05 0.000143420589109842 0.915619566935356 0.815789473684211 30.2 30 2 abnormal compact bone morphology 1.31456861576056e-05 0.000143420589109842 0.915619566935356 0.815789473684211 30.2 30 2 embryonic lethality, complete penetrance 3.82750713995487e-37 1.73107709284323e-34 0.914786259613846 0.815047021943574 30.2 30 2 abnormal axon morphology 1.71358764168577e-13 8.52509851738669e-12 0.914525636747859 0.814814814814815 30.2 30 2 abnormal atrioventricular cushion morphology 0.000262906683845372 0.00197577152889838 0.914525636747859 0.814814814814815 30.2 30 2 abnormal type II pneumocyte morphology 0.000262906683845372 0.00197577152889838 0.914525636747859 0.814814814814815 30.2 30 2 abnormal fetal cardiomyocyte proliferation 0.000262906683845372 0.00197577152889838 0.914525636747859 0.814814814814815 30.2 30 2 decreased circulating fructosamine level 0.000262906683845372 0.00197577152889838 0.914525636747859 0.814814814814815 30.2 30 2 thick interventricular septum 0.000262906683845372 0.00197577152889838 0.914525636747859 0.814814814814815 30.2 30 2 abnormal bone trabecula morphology 0.000262906683845372 0.00197577152889838 0.914525636747859 0.814814814814815 30.2 30 2 domed cranium 3.39142225981687e-09 9.12017607707509e-08 0.913931788931789 0.814285714285714 30.2 30 2 increased oxygen consumption 5.67574867199967e-11 2.09161849208877e-09 0.913558907744954 0.813953488372093 30.2 30 2 abnormal blood circulation 3.94400040157894e-06 4.94241863925824e-05 0.913558907744954 0.813953488372093 30.2 30 2 kidney failure 3.94400040157894e-06 4.94241863925824e-05 0.913558907744954 0.813953488372093 30.2 30 2 abnormal blood vessel morphology 1.57091168350729e-17 1.32462468227945e-15 0.913378896137517 0.813793103448276 30.2 30 2 overriding aortic valve 1.18966459379351e-06 1.68284645385123e-05 0.911927552552553 0.8125 30.2 30 2 small heart 1.18966459379351e-06 1.68284645385123e-05 0.911927552552553 0.8125 30.2 30 2 abnormal depression-related behavior 7.7266865616036e-05 0.000679156636819397 0.911927552552553 0.8125 30.2 30 2 abnormal mouth morphology 0.00566584334123101 0.0254860493875445 0.911927552552553 0.8125 30.2 30 2 reduced male mating frequency 0.00566584334123101 0.0254860493875445 0.911927552552553 0.8125 30.2 30 2 small pancreas 0.00566584334123101 0.0254860493875445 0.911927552552553 0.8125 30.2 30 2 blepharitis 0.00566584334123101 0.0254860493875445 0.911927552552553 0.8125 30.2 30 2 dystonia 0.00566584334123101 0.0254860493875445 0.911927552552553 0.8125 30.2 30 2 dilated respiratory conducting tubes 0.00566584334123101 0.0254860493875445 0.911927552552553 0.8125 30.2 30 2 abnormal pulmonary alveolus wall morphology 0.00566584334123101 0.0254860493875445 0.911927552552553 0.8125 30.2 30 2 cardiac fibrosis 9.85648167538117e-11 3.45323917852263e-09 0.911102278749338 0.811764705882353 30.2 30 2 increased circulating bilirubin level 3.60400965565246e-07 6.24736865396201e-06 0.910604000226642 0.811320754716981 30.2 30 2 oxidative stress 3.03779822278607e-11 1.15366764567639e-09 0.910368702035369 0.811111111111111 30.2 30 2 preweaning lethality, complete penetrance 1.17418455097371e-82 1.94718938036473e-79 0.910031653274897 0.810810810810811 30.2 30 2 increased circulating phosphate level 2.29410491919577e-05 0.000232447494358431 0.910031653274896 0.810810810810811 30.2 30 2 abnormal chromosome morphology 2.29410491919577e-05 0.000232447494358431 0.910031653274896 0.810810810810811 30.2 30 2 abnormal hair follicle development 2.29410491919577e-05 0.000232447494358431 0.910031653274896 0.810810810810811 30.2 30 2 abnormal humerus morphology 2.29410491919577e-05 0.000232447494358431 0.910031653274896 0.810810810810811 30.2 30 2 abnormal embryonic neuroepithelium morphology 1.09566848861031e-07 2.13762773758286e-06 0.909508646577612 0.810344827586207 30.2 30 2 abnormal muscle morphology 6.86369709529649e-06 8.03456307037647e-05 0.908587158587159 0.80952380952381 30.2 30 2 abnormal reproductive system morphology 6.86369709529649e-06 8.03456307037647e-05 0.908587158587159 0.80952380952381 30.2 30 2 abnormal spleen white pulp morphology 6.86369709529649e-06 8.03456307037647e-05 0.908587158587159 0.80952380952381 30.2 30 2 left pulmonary isomerism 0.00159394517356219 0.00923152181428628 0.908587158587159 0.80952380952381 30.2 30 2 abnormal embryonic/fetal subventricular zone morphology 0.00159394517356219 0.00923152181428628 0.908587158587159 0.80952380952381 30.2 30 2 complete atrioventricular septal defect 0.00159394517356219 0.00923152181428628 0.908587158587159 0.80952380952381 30.2 30 2 absent segment of posterior cerebral artery 0.00159394517356219 0.00923152181428628 0.908587158587159 0.80952380952381 30.2 30 2 prenatal lethality, incomplete penetrance 3.10191245853639e-34 1.28600120676821e-31 0.908235538169749 0.809210526315789 30.2 30 2 abnormal neural tube morphology 7.58542499373495e-19 6.86136169887843e-17 0.907597412227042 0.808641975308642 30.2 30 2 increased cellular sensitivity to gamma-irradiation 2.06577666284099e-06 2.79272796131357e-05 0.907450003194684 0.808510638297872 30.2 30 2 decreased grip strength 6.56456374141756e-25 1.25610402359817e-22 0.907122876300958 0.808219178082192 30.2 30 2 decreased circulating serum albumin level 5.00020611392895e-12 2.00613108199972e-10 0.90696757363424 0.808080808080808 30.2 30 2 liver hypoplasia 6.24687021433672e-07 9.84432354037681e-06 0.906531531531531 0.807692307692308 30.2 30 2 ventricular hypoplasia 0.000459313322322656 0.00324125358660314 0.906531531531531 0.807692307692308 30.2 30 2 increased leukemia incidence 0.000459313322322656 0.00324125358660314 0.906531531531531 0.807692307692308 30.2 30 2 decreased circulating glycerol level 0.000459313322322656 0.00324125358660314 0.906531531531531 0.807692307692308 30.2 30 2 increased bone mineral content 4.77136361731432e-13 2.30461495108143e-11 0.906135493291456 0.807339449541284 30.2 30 2 decreased birth body size 1.47534164710851e-13 7.41396433774225e-12 0.905774195247879 0.807017543859649 30.2 30 2 incomplete embryo turning 1.89630841120486e-07 3.41816461802324e-06 0.905774195247879 0.807017543859649 30.2 30 2 increased hepatocellular carcinoma incidence 1.89630841120486e-07 3.41816461802324e-06 0.905774195247879 0.807017543859649 30.2 30 2 abnormal facial morphology 1.89630841120486e-07 3.41816461802324e-06 0.905774195247879 0.807017543859649 30.2 30 2 kyphosis 2.34412090324427e-17 1.94366691560671e-15 0.90538038038038 0.806666666666667 30.2 30 2 pericardial effusion 5.77471573335831e-08 1.1920834345833e-06 0.90513900997772 0.806451612903226 30.2 30 2 abnormal eyelid morphology 0.000134467344912369 0.00109848118380794 0.90513900997772 0.806451612903226 30.2 30 2 abnormal object recognition memory 0.000134467344912369 0.00109848118380794 0.90513900997772 0.806451612903226 30.2 30 2 abnormal mitochondrial ATP synthesis coupled electron transport 0.000134467344912369 0.00109848118380794 0.90513900997772 0.806451612903226 30.2 30 2 abnormal kidney morphology 6.73437059985783e-20 6.70069874685855e-18 0.904311454311454 0.805714285714286 30.2 30 2 hydrops fetalis 5.39561664702321e-09 1.3765739907149e-07 0.904133299966633 0.805555555555556 30.2 30 2 abnormal trophoblast giant cell morphology 3.98095459172958e-05 0.000380870174881821 0.904133299966633 0.805555555555556 30.2 30 2 abnormal retinal blood vessel morphology 3.98095459172958e-05 0.000380870174881821 0.904133299966633 0.805555555555556 30.2 30 2 short snout 8.21806976987731e-13 3.85706576463581e-11 0.904133299966633 0.805555555555556 30.2 30 2 short limbs 1.56230189779181e-10 5.14731916656574e-09 0.903058230644438 0.804597701149425 30.2 30 2 preweaning lethality, incomplete penetrance 2.81972304705002e-44 1.40281221590739e-41 0.902837434011028 0.80440097799511 30.2 30 2 embryonic lethality during organogenesis, incomplete penetrance 1.72654391218265e-25 3.57898165129529e-23 0.902777777777778 0.804347826086957 30.2 30 2 failure to gastrulate 3.57055091558329e-06 4.54820050058358e-05 0.902777777777778 0.804347826086957 30.2 30 2 embryonic lethality between implantation and placentation, complete penetrance 3.57055091558329e-06 4.54820050058358e-05 0.902777777777778 0.804347826086957 30.2 30 2 abnormal extraembryonic tissue morphology 4.57433220065752e-12 1.85018721124156e-10 0.902299358181711 0.803921568627451 30.2 30 2 abnormal cervical vertebrae morphology 1.07820132713785e-06 1.55479756594516e-05 0.902299358181711 0.803921568627451 30.2 30 2 failure of chorioallantoic fusion 1.07820132713785e-06 1.55479756594516e-05 0.902299358181711 0.803921568627451 30.2 30 2 increased circulating alkaline phosphatase level 3.54451958142816e-18 3.04034222717329e-16 0.900669187706225 0.802469135802469 30.2 30 2 abnormal glucose homeostasis 3.28073073254044e-20 3.33094599885484e-18 0.90036465036465 0.802197802197802 30.2 30 2 abnormal kidney development 1.70656455817624e-07 3.16796965556971e-06 0.897897897897898 0.8 30.2 30 2 abnormal incisor morphology 1.70656455817624e-07 3.16796965556971e-06 0.897897897897898 0.8 30.2 30 2 muscular ventricular septal defect 1.70656455817624e-07 3.16796965556971e-06 0.897897897897898 0.8 30.2 30 2 abnormal embryo turning 5.61322035807382e-07 8.95056771840296e-06 0.897897897897898 0.8 30.2 30 2 abnormal joint morphology 5.61322035807382e-07 8.95056771840296e-06 0.897897897897898 0.8 30.2 30 2 abnormal rostral-caudal axis patterning 5.61322035807382e-07 8.95056771840296e-06 0.897897897897898 0.8 30.2 30 2 decreased circulating total protein level 5.61322035807382e-07 8.95056771840296e-06 0.897897897897898 0.8 30.2 30 2 emphysema 0.000232428772917391 0.00179554836221121 0.897897897897898 0.8 30.2 30 2 disorganized myocardium 0.000232428772917391 0.00179554836221121 0.897897897897898 0.8 30.2 30 2 abnormal synaptic transmission 0.000232428772917391 0.00179554836221121 0.897897897897898 0.8 30.2 30 2 abnormal cellular respiration 0.000232428772917391 0.00179554836221121 0.897897897897898 0.8 30.2 30 2 abnormal basioccipital bone morphology 0.00277402312624266 0.014331012516155 0.897897897897898 0.8 30.2 30 2 abnormal cell proliferation 0.00277402312624266 0.014331012516155 0.897897897897898 0.8 30.2 30 2 abnormal circulating enzyme level 0.00277402312624266 0.014331012516155 0.897897897897898 0.8 30.2 30 2 abnormal hearing physiology 0.00277402312624266 0.014331012516155 0.897897897897898 0.8 30.2 30 2 abnormal fibula morphology 0.00277402312624266 0.014331012516155 0.897897897897898 0.8 30.2 30 2 abnormal trachea morphology 0.00277402312624266 0.014331012516155 0.897897897897898 0.8 30.2 30 2 absent placental labyrinth 0.00277402312624266 0.014331012516155 0.897897897897898 0.8 30.2 30 2 abnormal physiological neovascularization 0.00277402312624266 0.014331012516155 0.897897897897898 0.8 30.2 30 2 abnormal heart right ventricle morphology 0.00277402312624266 0.014331012516155 0.897897897897898 0.8 30.2 30 2 decreased muscle cell glucose uptake 0.00277402312624266 0.014331012516155 0.897897897897898 0.8 30.2 30 2 abnormal fontanelle morphology 0.00992193972886903 0.0409640250216792 0.897897897897898 0.8 30.2 30 2 interdigital webbing 0.00992193972886903 0.0409640250216792 0.897897897897898 0.8 30.2 30 2 placental labyrinth hypoplasia 0.00992193972886903 0.0409640250216792 0.897897897897898 0.8 30.2 30 2 abnormal respiratory system morphology 0.00992193972886903 0.0409640250216792 0.897897897897898 0.8 30.2 30 2 abnormal cricoid cartilage morphology 0.00992193972886903 0.0409640250216792 0.897897897897898 0.8 30.2 30 2 abnormal lymph node B cell domain morphology 0.00992193972886903 0.0409640250216792 0.897897897897898 0.8 30.2 30 2 dilated ureter 0.00992193972886903 0.0409640250216792 0.897897897897898 0.8 30.2 30 2 abnormal glial cell morphology 0.00992193972886903 0.0409640250216792 0.897897897897898 0.8 30.2 30 2 abnormal ear development 0.00992193972886903 0.0409640250216792 0.897897897897898 0.8 30.2 30 2 abnormal zygomatic bone morphology 0.00992193972886903 0.0409640250216792 0.897897897897898 0.8 30.2 30 2 abnormal neurotransmitter secretion 0.00992193972886903 0.0409640250216792 0.897897897897898 0.8 30.2 30 2 decreased thymocyte apoptosis 0.00992193972886903 0.0409640250216792 0.897897897897898 0.8 30.2 30 2 absent chorion 0.00992193972886903 0.0409640250216792 0.897897897897898 0.8 30.2 30 2 abnormal branching involved in lung morphogenesis 0.00992193972886903 0.0409640250216792 0.897897897897898 0.8 30.2 30 2 abnormal lateral semicircular canal morphology 0.0371386957508826 0.112799152234824 0.897897897897898 0.8 30.2 30 2 abnormal otic capsule morphology 0.0371386957508826 0.112799152234824 0.897897897897898 0.8 30.2 30 2 abnormal prostate gland epithelium morphology 0.0371386957508826 0.112799152234824 0.897897897897898 0.8 30.2 30 2 abnormal epidermis suprabasal layer morphology 0.0371386957508826 0.112799152234824 0.897897897897898 0.8 30.2 30 2 abnormal immune cell physiology 0.0371386957508826 0.112799152234824 0.897897897897898 0.8 30.2 30 2 abnormal primordial germ cell migration 0.0371386957508826 0.112799152234824 0.897897897897898 0.8 30.2 30 2 acrania 0.0371386957508826 0.112799152234824 0.897897897897898 0.8 30.2 30 2 abnormal scala media morphology 0.0371386957508826 0.112799152234824 0.897897897897898 0.8 30.2 30 2 intestinal hypoperistalsis 0.0371386957508826 0.112799152234824 0.897897897897898 0.8 30.2 30 2 abnormal glial cell physiology 0.0371386957508826 0.112799152234824 0.897897897897898 0.8 30.2 30 2 absent CD4-positive, alpha beta T cells 0.0371386957508826 0.112799152234824 0.897897897897898 0.8 30.2 30 2 increased left ventricle diastolic pressure 0.0371386957508826 0.112799152234824 0.897897897897898 0.8 30.2 30 2 abnormal hindlimb zeugopod morphology 0.0371386957508826 0.112799152234824 0.897897897897898 0.8 30.2 30 2 abnormal reproductive system development 0.0371386957508826 0.112799152234824 0.897897897897898 0.8 30.2 30 2 abnormal embryonic erythrocyte morphology 0.0371386957508826 0.112799152234824 0.897897897897898 0.8 30.2 30 2 abnormal placental transport 0.0371386957508826 0.112799152234824 0.897897897897898 0.8 30.2 30 2 abnormal utricular macula morphology 0.0371386957508826 0.112799152234824 0.897897897897898 0.8 30.2 30 2 abnormal deltoid tuberosity morphology 0.0371386957508826 0.112799152234824 0.897897897897898 0.8 30.2 30 2 abnormal corneal endothelium morphology 0.0371386957508826 0.112799152234824 0.897897897897898 0.8 30.2 30 2 increased susceptibility to atherosclerosis 0.0371386957508826 0.112799152234824 0.897897897897898 0.8 30.2 30 2 decreased thyroxine level 0.0371386957508826 0.112799152234824 0.897897897897898 0.8 30.2 30 2 vascular smooth muscle hyperplasia 0.0371386957508826 0.112799152234824 0.897897897897898 0.8 30.2 30 2 increased platelet aggregation 0.0371386957508826 0.112799152234824 0.897897897897898 0.8 30.2 30 2 abnormal spinal cord dorsal column morphology 0.0371386957508826 0.112799152234824 0.897897897897898 0.8 30.2 30 2 ventricular premature beat 0.0371386957508826 0.112799152234824 0.897897897897898 0.8 30.2 30 2 increased circulating fructosamine level 0.0371386957508826 0.112799152234824 0.897897897897898 0.8 30.2 30 2 acanthocytosis 0.0371386957508826 0.112799152234824 0.897897897897898 0.8 30.2 30 2 increased kidney iron level 0.0371386957508826 0.112799152234824 0.897897897897898 0.8 30.2 30 2 common ventricle 0.0371386957508826 0.112799152234824 0.897897897897898 0.8 30.2 30 2 abnormal inferior vena cava valve morphology 0.0371386957508826 0.112799152234824 0.897897897897898 0.8 30.2 30 2 increased compact bone area 0.0371386957508826 0.112799152234824 0.897897897897898 0.8 30.2 30 2 abnormal circadian temperature homeostasis 0.0371386957508826 0.112799152234824 0.897897897897898 0.8 30.2 30 2 decreased macrophage cytokine production 0.0371386957508826 0.112799152234824 0.897897897897898 0.8 30.2 30 2 decreased macrophage apoptosis 0.0371386957508826 0.112799152234824 0.897897897897898 0.8 30.2 30 2 hemorrhage 2.4570975465752e-25 4.88962411768466e-23 0.897897897897898 0.8 30.2 30 2 abnormal hindlimb morphology 1.85277199747647e-06 2.52535361299875e-05 0.897897897897898 0.8 30.2 30 2 abnormal autopod morphology 6.14169716667779e-06 7.30979507278039e-05 0.897897897897898 0.8 30.2 30 2 irregular heartbeat 6.14169716667779e-06 7.30979507278039e-05 0.897897897897898 0.8 30.2 30 2 albuminuria 6.14169716667779e-06 7.30979507278039e-05 0.897897897897898 0.8 30.2 30 2 abnormal dermal layer morphology 6.86693772830994e-05 0.000612240415740895 0.897897897897898 0.8 30.2 30 2 increased circulating serum albumin level 6.86693772830994e-05 0.000612240415740895 0.897897897897898 0.8 30.2 30 2 increased red blood cell distribution width 6.86693772830994e-05 0.000612240415740895 0.897897897897898 0.8 30.2 30 2 impaired adaptive thermogenesis 6.86693772830994e-05 0.000612240415740895 0.897897897897898 0.8 30.2 30 2 decreased bone mineralization 6.86693772830994e-05 0.000612240415740895 0.897897897897898 0.8 30.2 30 2 ruffled hair 0.000796161704387019 0.00518442994676102 0.897897897897898 0.8 30.2 30 2 abnormal primitive streak morphology 0.000796161704387019 0.00518442994676102 0.897897897897898 0.8 30.2 30 2 abnormal behavior 1.89237441629695e-29 5.88410170067333e-27 0.896282973621103 0.798561151079137 30.2 30 2 abnormal renal glomerulus morphology 2.18482259186478e-12 9.21143423265025e-11 0.895838499049508 0.798165137614679 30.2 30 2 decreased B cell proliferation 2.55264465517085e-09 6.93956675381147e-08 0.895056448853917 0.79746835443038 30.2 30 2 reduced female fertility 1.22176802186755e-24 2.17081996742538e-22 0.894995210727969 0.797413793103448 30.2 30 2 abnormal intestine morphology 8.32058246534686e-09 2.03915752537442e-07 0.894864459053648 0.797297297297297 30.2 30 2 increased insulin sensitivity 1.01319651959898e-15 7.00090650695125e-14 0.894758394758395 0.797202797202797 30.2 30 2 limb grasping 1.47735235377367e-19 1.41342845385077e-17 0.894197769197769 0.796703296703297 30.2 30 2 increased cell proliferation 9.59739525611758e-07 1.39204202329985e-05 0.893740963185408 0.796296296296296 30.2 30 2 impaired limb coordination 9.59739525611758e-07 1.39204202329985e-05 0.893740963185408 0.796296296296296 30.2 30 2 abnormal cell adhesion 9.59739525611758e-07 1.39204202329985e-05 0.893740963185408 0.796296296296296 30.2 30 2 decreased platelet aggregation 9.59739525611758e-07 1.39204202329985e-05 0.893740963185408 0.796296296296296 30.2 30 2 cardiac hypertrophy 3.90319876510543e-11 1.46003111702252e-09 0.893316786173929 0.795918367346939 30.2 30 2 abnormal long bone hypertrophic chondrocyte zone 3.1691875201883e-06 4.13824354670257e-05 0.893316786173929 0.795918367346939 30.2 30 2 hypoglycemia 1.26577017723622e-10 4.22631317567129e-09 0.893070489844683 0.795698924731183 30.2 30 2 osteoporosis 1.05110175674969e-05 0.000116723911603341 0.892796205296205 0.795454545454545 30.2 30 2 abnormal astrocyte morphology 1.05110175674969e-05 0.000116723911603341 0.892796205296205 0.795454545454545 30.2 30 2 prenatal lethality, complete penetrance 8.41531858807745e-29 2.46271823386384e-26 0.892245662929116 0.794964028776978 30.2 30 2 decreased B-1 B cell number 3.50517035036407e-05 0.00033795004831514 0.892142142142142 0.794871794871795 30.2 30 2 pericardial edema 4.62553273582622e-08 9.62846249403157e-07 0.891295707472178 0.794117647058823 30.2 30 2 short maxilla 0.000117702695583819 0.000982501527734057 0.891295707472178 0.794117647058823 30.2 30 2 increased width of hypertrophic chondrocyte zone 0.000117702695583819 0.000982501527734057 0.891295707472178 0.794117647058823 30.2 30 2 decreased susceptibility to hepatic steatosis 1.51361544845925e-07 2.86320793007025e-06 0.890771724105057 0.793650793650794 30.2 30 2 increased circulating aspartate transaminase level 1.51361544845925e-07 2.86320793007025e-06 0.890771724105057 0.793650793650794 30.2 30 2 increased blood urea nitrogen level 1.5385803498357e-15 1.03438341086927e-13 0.890157398778088 0.793103448275862 30.2 30 2 glomerulosclerosis 4.9654281144839e-07 8.12598844393336e-06 0.890157398778088 0.793103448275862 30.2 30 2 abnormal middle ear morphology 0.000398849655859676 0.00286053374654448 0.890157398778088 0.793103448275862 30.2 30 2 blood in lymph vessels 0.000398849655859676 0.00286053374654448 0.890157398778088 0.793103448275862 30.2 30 2 abnormal heart left ventricle morphology 2.40353667818106e-08 5.29097122741184e-07 0.888544794794795 0.791666666666667 30.2 30 2 retinal degeneration 1.12328100424125e-10 3.82761849047962e-09 0.888544794794795 0.791666666666667 30.2 30 2 abnormal malleus morphology 0.00136835454139797 0.00805628857213599 0.888544794794795 0.791666666666667 30.2 30 2 abnormal digestive system morphology 0.00136835454139797 0.00805628857213599 0.888544794794795 0.791666666666667 30.2 30 2 ocular hypertelorism 0.00136835454139797 0.00805628857213599 0.888544794794795 0.791666666666667 30.2 30 2 abnormal nursing 0.00136835454139797 0.00805628857213599 0.888544794794795 0.791666666666667 30.2 30 2 increased stereotypic behavior 0.00136835454139797 0.00805628857213599 0.888544794794795 0.791666666666667 30.2 30 2 abnormal primitive streak formation 0.00136835454139797 0.00805628857213599 0.888544794794795 0.791666666666667 30.2 30 2 abnormal cardiac muscle contractility 0.00136835454139797 0.00805628857213599 0.888544794794795 0.791666666666667 30.2 30 2 decreased fatty acid level 0.00136835454139797 0.00805628857213599 0.888544794794795 0.791666666666667 30.2 30 2 hypopigmentation 0.00136835454139797 0.00805628857213599 0.888544794794795 0.791666666666667 30.2 30 2 abnormal inner cell mass apoptosis 0.00136835454139797 0.00805628857213599 0.888544794794795 0.791666666666667 30.2 30 2 abnormal truncus arteriosus septation 0.00136835454139797 0.00805628857213599 0.888544794794795 0.791666666666667 30.2 30 2 reduced fertility 8.3925067969741e-15 5.13520715611654e-13 0.888208352237129 0.79136690647482 30.2 30 2 increased heart weight 8.3925067969741e-15 5.13520715611654e-13 0.888208352237129 0.79136690647482 30.2 30 2 increased grip strength 3.64079838863401e-10 1.16857883764221e-08 0.888030888030888 0.791208791208791 30.2 30 2 abnormal organ of Corti morphology 1.78936623826741e-05 0.0001870188452811 0.887457224666527 0.790697674418605 30.2 30 2 abnormal left-right axis patterning 1.78936623826741e-05 0.0001870188452811 0.887457224666527 0.790697674418605 30.2 30 2 decreased heart weight 3.83666961788123e-09 9.94137049424954e-08 0.88681273866459 0.790123456790123 30.2 30 2 absent vitelline blood vessels 8.41753791060579e-07 1.24634675908523e-05 0.886083451872925 0.789473684210526 30.2 30 2 decreased brain weight 8.41753791060579e-07 1.24634675908523e-05 0.886083451872925 0.789473684210526 30.2 30 2 increased grooming behavior 5.9673660570777e-05 0.000538795755607288 0.886083451872925 0.789473684210526 30.2 30 2 impaired branching involved in ureteric bud morphogenesis 5.9673660570777e-05 0.000538795755607288 0.886083451872925 0.789473684210526 30.2 30 2 abnormal triglyceride level 0.00477837470280618 0.0224056683755521 0.886083451872925 0.789473684210526 30.2 30 2 short vibrissae 0.00477837470280618 0.0224056683755521 0.886083451872925 0.789473684210526 30.2 30 2 abnormal stationary movement 0.00477837470280618 0.0224056683755521 0.886083451872925 0.789473684210526 30.2 30 2 stereotypic behavior 0.00477837470280618 0.0224056683755521 0.886083451872925 0.789473684210526 30.2 30 2 abnormal long term depression 0.00477837470280618 0.0224056683755521 0.886083451872925 0.789473684210526 30.2 30 2 increased malignant tumor incidence 0.00477837470280618 0.0224056683755521 0.886083451872925 0.789473684210526 30.2 30 2 decreased tumor incidence 0.00477837470280618 0.0224056683755521 0.886083451872925 0.789473684210526 30.2 30 2 abnormal ear morphology 0.00477837470280618 0.0224056683755521 0.886083451872925 0.789473684210526 30.2 30 2 abnormal neurotransmitter level 0.00477837470280618 0.0224056683755521 0.886083451872925 0.789473684210526 30.2 30 2 abnormal sternebra morphology 0.00477837470280618 0.0224056683755521 0.886083451872925 0.789473684210526 30.2 30 2 increased circulating VLDL cholesterol level 0.00477837470280618 0.0224056683755521 0.886083451872925 0.789473684210526 30.2 30 2 decreased eye pigmentation 0.00477837470280618 0.0224056683755521 0.886083451872925 0.789473684210526 30.2 30 2 abnormal epidermis stratum basale morphology 0.000200395789301717 0.00157998264940735 0.884293384293384 0.787878787878788 30.2 30 2 decreased brown adipose tissue amount 0.000200395789301717 0.00157998264940735 0.884293384293384 0.787878787878788 30.2 30 2 abnormal middle ear ossicle morphology 0.000200395789301717 0.00157998264940735 0.884293384293384 0.787878787878788 30.2 30 2 abnormal posture 6.4730751564111e-09 1.61017744515726e-07 0.883868243243243 0.7875 30.2 30 2 pulmonary hypoplasia 9.13821565072982e-06 0.000103324142869047 0.883569739952719 0.787234042553192 30.2 30 2 embryonic growth arrest 1.09711430722756e-22 1.51615102179364e-20 0.882214091821079 0.786026200873362 30.2 30 2 abnormal eye development 1.4207965953196e-06 1.9689312149624e-05 0.881864006864007 0.785714285714286 30.2 30 2 abnormal jaw morphology 0.000679125708097014 0.00447503363944721 0.881864006864007 0.785714285714286 30.2 30 2 absent corpus callosum 0.000679125708097014 0.00447503363944721 0.881864006864007 0.785714285714286 30.2 30 2 increased triglyceride level 0.000679125708097014 0.00447503363944721 0.881864006864007 0.785714285714286 30.2 30 2 midline facial cleft 0.01715013593038 0.0632014268545484 0.881864006864007 0.785714285714286 30.2 30 2 abnormal kidney blood vessel morphology 0.01715013593038 0.0632014268545484 0.881864006864007 0.785714285714286 30.2 30 2 absent visceral yolk sac blood islands 0.01715013593038 0.0632014268545484 0.881864006864007 0.785714285714286 30.2 30 2 abnormal adrenal gland secretion 0.01715013593038 0.0632014268545484 0.881864006864007 0.785714285714286 30.2 30 2 abnormal spleen periarteriolar lymphoid sheath morphology 0.01715013593038 0.0632014268545484 0.881864006864007 0.785714285714286 30.2 30 2 intestinal obstruction 0.01715013593038 0.0632014268545484 0.881864006864007 0.785714285714286 30.2 30 2 abnormal voluntary movement 0.01715013593038 0.0632014268545484 0.881864006864007 0.785714285714286 30.2 30 2 abnormal decidualization 0.01715013593038 0.0632014268545484 0.881864006864007 0.785714285714286 30.2 30 2 skeletal muscle necrosis 0.01715013593038 0.0632014268545484 0.881864006864007 0.785714285714286 30.2 30 2 increased circulating growth hormone level 0.01715013593038 0.0632014268545484 0.881864006864007 0.785714285714286 30.2 30 2 spina bifida occulta 0.01715013593038 0.0632014268545484 0.881864006864007 0.785714285714286 30.2 30 2 sternebra fusion 0.01715013593038 0.0632014268545484 0.881864006864007 0.785714285714286 30.2 30 2 increased stomach tumor incidence 0.01715013593038 0.0632014268545484 0.881864006864007 0.785714285714286 30.2 30 2 abnormal rib morphology 6.74760172266656e-14 3.64883897502893e-12 0.881270159047937 0.785185185185185 30.2 30 2 abnormal somite development 1.08862064133968e-08 2.62907169449752e-07 0.880849203634014 0.784810126582278 30.2 30 2 abnormal myocardium layer morphology 1.08862064133968e-08 2.62907169449752e-07 0.880849203634014 0.784810126582278 30.2 30 2 impaired balance 8.63924066575159e-11 3.04824271717122e-09 0.880292056762645 0.784313725490196 30.2 30 2 abnormal trophoblast layer morphology 4.66939261688963e-06 5.65212366642966e-05 0.880292056762645 0.784313725490196 30.2 30 2 abnormal thrombosis 4.66939261688963e-06 5.65212366642966e-05 0.880292056762645 0.784313725490196 30.2 30 2 abnormal angiogenesis 3.53529447631802e-08 7.68038865488304e-07 0.8796972648324 0.783783783783784 30.2 30 2 pale liver 3.53529447631802e-08 7.68038865488304e-07 0.8796972648324 0.783783783783784 30.2 30 2 increased brown adipose tissue amount 0.000100957846546647 0.000855647847648325 0.8796972648324 0.783783783783784 30.2 30 2 abnormal branching of the mammary ductal tree 0.000100957846546647 0.000855647847648325 0.8796972648324 0.783783783783784 30.2 30 2 decreased bone mineral content 1.95593712172016e-20 2.07038025118251e-18 0.879551426426426 0.783653846153846 30.2 30 2 decreased erythrocyte cell number 9.25984851859981e-16 6.48841498310339e-14 0.879310839501922 0.78343949044586 30.2 30 2 abnormal eating behavior 7.29251042972249e-07 1.11631505808829e-05 0.879191691691692 0.783333333333333 30.2 30 2 absent mesoderm 7.29251042972249e-07 1.11631505808829e-05 0.879191691691692 0.783333333333333 30.2 30 2 pallor 2.44342503970858e-17 1.99279337254921e-15 0.878657228657229 0.782857142857143 30.2 30 2 abnormal cell death 1.5397823670618e-05 0.00016298760161984 0.878378378378378 0.782608695652174 30.2 30 2 abnormal carpal bone morphology 0.00233016246218474 0.0126694625676165 0.878378378378378 0.782608695652174 30.2 30 2 abnormal postnatal growth 0.00233016246218474 0.0126694625676165 0.878378378378378 0.782608695652174 30.2 30 2 conjunctivitis 0.00233016246218474 0.0126694625676165 0.878378378378378 0.782608695652174 30.2 30 2 dilated heart 0.00233016246218474 0.0126694625676165 0.878378378378378 0.782608695652174 30.2 30 2 abnormal vertebral artery topology 0.00233016246218474 0.0126694625676165 0.878378378378378 0.782608695652174 30.2 30 2 small liver 1.82479564321552e-08 4.2029436689802e-07 0.877752752752753 0.782051282051282 30.2 30 2 abnormal cornea morphology 1.82479564321552e-08 4.2029436689802e-07 0.877752752752753 0.782051282051282 30.2 30 2 increased circulating alanine transaminase level 1.82479564321552e-08 4.2029436689802e-07 0.877752752752753 0.782051282051282 30.2 30 2 absent gastric milk in neonates 1.82479564321552e-08 4.2029436689802e-07 0.877752752752753 0.782051282051282 30.2 30 2 abnormal platelet physiology 2.38740219741078e-06 3.20143556121795e-05 0.877491127491128 0.781818181818182 30.2 30 2 abnormal heart atrium morphology 0.000338754770970698 0.00245313680579218 0.876853415915916 0.78125 30.2 30 2 increased fibroblast apoptosis 0.000338754770970698 0.00245313680579218 0.876853415915916 0.78125 30.2 30 2 abnormal mammary gland development 5.09851037506421e-05 0.000470595345379303 0.875997949168681 0.780487804878049 30.2 30 2 abnormal cell differentiation 5.09851037506421e-05 0.000470595345379303 0.875997949168681 0.780487804878049 30.2 30 2 increased bone trabecula number 5.09851037506421e-05 0.000470595345379303 0.875997949168681 0.780487804878049 30.2 30 2 enlarged heart 3.91718594246458e-22 4.99692309327212e-20 0.875643962928446 0.780172413793103 30.2 30 2 abnormal axon extension 7.8364789188939e-06 9.00380661004553e-05 0.87545045045045 0.78 30.2 30 2 decreased respiratory quotient 7.8364789188939e-06 9.00380661004553e-05 0.87545045045045 0.78 30.2 30 2 abnormal colon morphology 1.22142329660537e-06 1.72141102000333e-05 0.875069985239477 0.779661016949153 30.2 30 2 edema 1.13466797272399e-16 8.42533308104752e-15 0.874406383127313 0.779069767441861 30.2 30 2 decreased body weight 4.3590223401379e-112 2.16861361421861e-108 0.873057023097411 0.777867528271405 30.2 30 2 reduced long term depression 0.000169678787063412 0.00134633487342978 0.872956289622956 0.777777777777778 30.2 30 2 right pulmonary isomerism 0.00813784180576502 0.0344559684967498 0.872956289622956 0.777777777777778 30.2 30 2 abnormal thymus cortex morphology 0.00813784180576502 0.0344559684967498 0.872956289622956 0.777777777777778 30.2 30 2 abnormal Peyer's patch follicle morphology 0.00813784180576502 0.0344559684967498 0.872956289622956 0.777777777777778 30.2 30 2 abnormal metacarpal bone morphology 0.00813784180576502 0.0344559684967498 0.872956289622956 0.777777777777778 30.2 30 2 decreased cellular sensitivity to gamma-irradiation 0.00813784180576502 0.0344559684967498 0.872956289622956 0.777777777777778 30.2 30 2 darkened coat color 0.00813784180576502 0.0344559684967498 0.872956289622956 0.777777777777778 30.2 30 2 small thoracic cage 0.00813784180576502 0.0344559684967498 0.872956289622956 0.777777777777778 30.2 30 2 increased gastrointestinal tumor incidence 0.00813784180576502 0.0344559684967498 0.872956289622956 0.777777777777778 30.2 30 2 decreased tumor latency 0.00813784180576502 0.0344559684967498 0.872956289622956 0.777777777777778 30.2 30 2 crypts of Lieberkuhn abscesses 0.0645816223113142 0.166473352849113 0.872956289622956 0.777777777777778 30.2 30 2 abnormal urinary bladder urothelium morphology 0.0645816223113142 0.166473352849113 0.872956289622956 0.777777777777778 30.2 30 2 absent parathyroid glands 0.0645816223113142 0.166473352849113 0.872956289622956 0.777777777777778 30.2 30 2 abnormal sympathetic neuron morphology 0.0645816223113142 0.166473352849113 0.872956289622956 0.777777777777778 30.2 30 2 abnormal cholinergic neuron morphology 0.0645816223113142 0.166473352849113 0.872956289622956 0.777777777777778 30.2 30 2 wavy vibrissae 0.0645816223113142 0.166473352849113 0.872956289622956 0.777777777777778 30.2 30 2 abnormal NMDA-mediated synaptic currents 0.0645816223113142 0.166473352849113 0.872956289622956 0.777777777777778 30.2 30 2 abnormal postural reflex 0.0645816223113142 0.166473352849113 0.872956289622956 0.777777777777778 30.2 30 2 abnormal abdominal wall morphology 0.0645816223113142 0.166473352849113 0.872956289622956 0.777777777777778 30.2 30 2 biliary cyst 0.0645816223113142 0.166473352849113 0.872956289622956 0.777777777777778 30.2 30 2 priapism 0.0645816223113142 0.166473352849113 0.872956289622956 0.777777777777778 30.2 30 2 premature bone ossification 0.0645816223113142 0.166473352849113 0.872956289622956 0.777777777777778 30.2 30 2 premature neuronal precursor differentiation 0.0645816223113142 0.166473352849113 0.872956289622956 0.777777777777778 30.2 30 2 short frontal bone 0.0645816223113142 0.166473352849113 0.872956289622956 0.777777777777778 30.2 30 2 abnormal CNS synapse formation 0.0645816223113142 0.166473352849113 0.872956289622956 0.777777777777778 30.2 30 2 abnormal gallbladder physiology 0.0645816223113142 0.166473352849113 0.872956289622956 0.777777777777778 30.2 30 2 abnormal posterior eye segment morphology 0.0645816223113142 0.166473352849113 0.872956289622956 0.777777777777778 30.2 30 2 abnormal oxygen consumption 0.0645816223113142 0.166473352849113 0.872956289622956 0.777777777777778 30.2 30 2 absent adrenal gland 0.0645816223113142 0.166473352849113 0.872956289622956 0.777777777777778 30.2 30 2 abnormal leukopoiesis 0.0645816223113142 0.166473352849113 0.872956289622956 0.777777777777778 30.2 30 2 enhanced conditioned place preference behavior 0.0645816223113142 0.166473352849113 0.872956289622956 0.777777777777778 30.2 30 2 abnormal liver vasculature morphology 0.0645816223113142 0.166473352849113 0.872956289622956 0.777777777777778 30.2 30 2 multiflagellated sperm 0.0645816223113142 0.166473352849113 0.872956289622956 0.777777777777778 30.2 30 2 abnormal hyoid bone lesser horn morphology 0.0645816223113142 0.166473352849113 0.872956289622956 0.777777777777778 30.2 30 2 decreased transitional stage T1 B cell number 0.0645816223113142 0.166473352849113 0.872956289622956 0.777777777777778 30.2 30 2 abnormal cerebellar layer morphology 0.0645816223113142 0.166473352849113 0.872956289622956 0.777777777777778 30.2 30 2 axonal spheroids 0.0645816223113142 0.166473352849113 0.872956289622956 0.777777777777778 30.2 30 2 retropulsion 0.0645816223113142 0.166473352849113 0.872956289622956 0.777777777777778 30.2 30 2 prolonged RR interval 0.0645816223113142 0.166473352849113 0.872956289622956 0.777777777777778 30.2 30 2 decreased effector memory CD4-positive, alpha-beta T cell number 0.0645816223113142 0.166473352849113 0.872956289622956 0.777777777777778 30.2 30 2 abnormal pulmonary alveolar parenchyma morphology 0.0645816223113142 0.166473352849113 0.872956289622956 0.777777777777778 30.2 30 2 decreased airway resistance 0.0645816223113142 0.166473352849113 0.872956289622956 0.777777777777778 30.2 30 2 abnormal ureteric bud invasion 0.0645816223113142 0.166473352849113 0.872956289622956 0.777777777777778 30.2 30 2 increased core body temperature 0.0645816223113142 0.166473352849113 0.872956289622956 0.777777777777778 30.2 30 2 abnormal infrahyoid muscle connection 0.0645816223113142 0.166473352849113 0.872956289622956 0.777777777777778 30.2 30 2 abnormal coronary sinus connection 0.0645816223113142 0.166473352849113 0.872956289622956 0.777777777777778 30.2 30 2 decreased fatty acid oxidation 0.0645816223113142 0.166473352849113 0.872956289622956 0.777777777777778 30.2 30 2 decreased bone mineral density of femur 0.0645816223113142 0.166473352849113 0.872956289622956 0.777777777777778 30.2 30 2 decreased platelet dense granule number 0.0645816223113142 0.166473352849113 0.872956289622956 0.777777777777778 30.2 30 2 abnormal neuronal precursor proliferation 3.99291821673161e-06 4.99114777091451e-05 0.872956289622956 0.777777777777778 30.2 30 2 small placenta 2.58036389703639e-05 0.000257260729213548 0.872956289622956 0.777777777777778 30.2 30 2 abnormal trigeminal nerve morphology 0.00114673655699315 0.00692356112990404 0.872956289622956 0.777777777777778 30.2 30 2 abnormal trigeminal ganglion morphology 0.00114673655699315 0.00692356112990404 0.872956289622956 0.777777777777778 30.2 30 2 increased brain weight 0.00114673655699315 0.00692356112990404 0.872956289622956 0.777777777777778 30.2 30 2 increased mean corpuscular hemoglobin 4.0221860803125e-10 1.28271639420222e-08 0.872956289622956 0.777777777777778 30.2 30 2 gliosis 6.25287686182728e-07 9.84432354037681e-06 0.872956289622956 0.777777777777778 30.2 30 2 abnormal lipid homeostasis 8.73436781915116e-13 4.06107288787636e-11 0.871996996996997 0.776923076923077 30.2 30 2 decreased compact bone thickness 3.20300595312367e-07 5.61089951295431e-06 0.871094975572588 0.776119402985075 30.2 30 2 decreased white adipose tissue amount 3.20300595312367e-07 5.61089951295431e-06 0.871094975572588 0.776119402985075 30.2 30 2 liver inflammation 8.95910054067481e-12 3.56572201518858e-10 0.869838588588589 0.775 30.2 30 2 perinatal lethality 8.52867449638565e-05 0.000736634646172198 0.869838588588589 0.775 30.2 30 2 abnormal skin pigmentation 8.52867449638565e-05 0.000736634646172198 0.869838588588589 0.775 30.2 30 2 abnormal pancreatic beta cell morphology 8.52867449638565e-05 0.000736634646172198 0.869838588588589 0.775 30.2 30 2 abnormal heart morphology 2.57861634888821e-21 2.9138763138409e-19 0.86971711971712 0.774891774891775 30.2 30 2 abnormal hepatocyte morphology 5.55122209290264e-11 2.06099476956647e-09 0.869585802018234 0.774774774774775 30.2 30 2 corneal opacity 1.64167576874052e-07 3.08201394320155e-06 0.869443387049021 0.774647887323944 30.2 30 2 increased circulating free fatty acid level 1.64167576874052e-07 3.08201394320155e-06 0.869443387049021 0.774647887323944 30.2 30 2 postnatal growth retardation 3.87624094507982e-54 2.41053733772151e-51 0.869288406053112 0.774509803921569 30.2 30 2 abnormal cardiovascular system physiology 7.49825213969311e-13 3.55274327571174e-11 0.869205671837251 0.774436090225564 30.2 30 2 impaired glucose tolerance 1.12770029771363e-22 1.51629972462846e-20 0.868933449578611 0.774193548387097 30.2 30 2 abnormal nose morphology 0.000568296526077469 0.00380521563557928 0.868933449578611 0.774193548387097 30.2 30 2 abnormal CD8-positive, alpha beta T cell morphology 0.000568296526077469 0.00380521563557928 0.868933449578611 0.774193548387097 30.2 30 2 small cranium 0.000568296526077469 0.00380521563557928 0.868933449578611 0.774193548387097 30.2 30 2 abnormal skeleton morphology 2.86849939622123e-11 1.09775265355389e-09 0.868618618618619 0.773913043478261 30.2 30 2 decreased hemoglobin content 2.00865839609815e-13 9.89413417880029e-12 0.867649564458075 0.773049645390071 30.2 30 2 abnormal vascular development 5.31461622914761e-07 8.61244812378155e-06 0.867287742287742 0.772727272727273 30.2 30 2 renal interstitial fibrosis 4.29946547542765e-05 0.000408983570559323 0.867287742287742 0.772727272727273 30.2 30 2 abnormal basisphenoid bone morphology 0.00392832962164311 0.0189374417322427 0.867287742287742 0.772727272727273 30.2 30 2 abnormal enterocyte morphology 0.00392832962164311 0.0189374417322427 0.867287742287742 0.772727272727273 30.2 30 2 increased body size 0.00392832962164311 0.0189374417322427 0.867287742287742 0.772727272727273 30.2 30 2 abnormal germ layer development 0.00392832962164311 0.0189374417322427 0.867287742287742 0.772727272727273 30.2 30 2 intestinal inflammation 0.00392832962164311 0.0189374417322427 0.867287742287742 0.772727272727273 30.2 30 2 abnormal oogenesis 0.00392832962164311 0.0189374417322427 0.867287742287742 0.772727272727273 30.2 30 2 increased skin papilloma incidence 0.00392832962164311 0.0189374417322427 0.867287742287742 0.772727272727273 30.2 30 2 abnormal lysosome physiology 0.00392832962164311 0.0189374417322427 0.867287742287742 0.772727272727273 30.2 30 2 abnormal vascular branching morphogenesis 0.00392832962164311 0.0189374417322427 0.867287742287742 0.772727272727273 30.2 30 2 abnormal cochlear sensory epithelium morphology 0.00392832962164311 0.0189374417322427 0.867287742287742 0.772727272727273 30.2 30 2 decreased cardiac output 0.00392832962164311 0.0189374417322427 0.867287742287742 0.772727272727273 30.2 30 2 cleft upper lip 0.00392832962164311 0.0189374417322427 0.867287742287742 0.772727272727273 30.2 30 2 increased adenoma incidence 0.00392832962164311 0.0189374417322427 0.867287742287742 0.772727272727273 30.2 30 2 impaired humoral immune response 0.00392832962164311 0.0189374417322427 0.867287742287742 0.772727272727273 30.2 30 2 abnormal heart development 8.73412971532655e-15 5.23521630527104e-13 0.86664195841411 0.772151898734177 30.2 30 2 abnormal locomotor behavior 3.54928634621771e-09 9.34269818647254e-08 0.866178678678679 0.771739130434783 30.2 30 2 ovary cysts 0.000283190144848747 0.00209341897566496 0.865830115830116 0.771428571428571 30.2 30 2 decreased glycogen level 0.000283190144848747 0.00209341897566496 0.865830115830116 0.771428571428571 30.2 30 2 abnormal hippocampus pyramidal cell morphology 0.000283190144848747 0.00209341897566496 0.865830115830116 0.771428571428571 30.2 30 2 microphthalmia 2.78273538891334e-14 1.60978006509813e-12 0.865620522483267 0.77124183006536 30.2 30 2 short tail 2.21739228296807e-08 4.95003533492447e-07 0.865443757010022 0.771084337349398 30.2 30 2 oligodactyly 2.17290234365306e-05 0.000221975136748952 0.865162037037037 0.770833333333333 30.2 30 2 abnormal osteoclast morphology 2.17290234365306e-05 0.000221975136748952 0.865162037037037 0.770833333333333 30.2 30 2 increased granulocyte number 1.39144979694352e-07 2.65228457463371e-06 0.864530070611152 0.77027027027027 30.2 30 2 decreased body length 3.07300886889372e-24 4.93168358798266e-22 0.864308651717411 0.77007299270073 30.2 30 2 premature death 1.16399436478933e-73 1.44771799120673e-70 0.864265833778029 0.770034843205575 30.2 30 2 enlarged liver 9.40181351242556e-10 2.78416798954269e-08 0.864226726726727 0.77 30.2 30 2 abnormal liver physiology 9.40181351242556e-10 2.78416798954269e-08 0.864226726726727 0.77 30.2 30 2 decreased body size 5.33880360984688e-68 4.42675799316471e-65 0.863579745158693 0.769423558897243 30.2 30 2 cachexia 4.84066303342515e-10 1.52419611337279e-08 0.863363363363363 0.769230769230769 30.2 30 2 abnormal snout morphology 1.10054585724648e-05 0.000121401677157455 0.863363363363363 0.769230769230769 30.2 30 2 short premaxilla 0.0292062872885048 0.0921377801270205 0.863363363363363 0.769230769230769 30.2 30 2 absent common myeloid progenitor cells 0.0292062872885048 0.0921377801270205 0.863363363363363 0.769230769230769 30.2 30 2 short hair 0.0292062872885048 0.0921377801270205 0.863363363363363 0.769230769230769 30.2 30 2 abnormal renal/urinary system morphology 0.0292062872885048 0.0921377801270205 0.863363363363363 0.769230769230769 30.2 30 2 tight skin 0.0292062872885048 0.0921377801270205 0.863363363363363 0.769230769230769 30.2 30 2 increased pituitary adenoma incidence 0.0292062872885048 0.0921377801270205 0.863363363363363 0.769230769230769 30.2 30 2 abnormal lung interstitium morphology 0.0292062872885048 0.0921377801270205 0.863363363363363 0.769230769230769 30.2 30 2 abnormal otolith morphology 0.0292062872885048 0.0921377801270205 0.863363363363363 0.769230769230769 30.2 30 2 abnormal telomere length 0.0292062872885048 0.0921377801270205 0.863363363363363 0.769230769230769 30.2 30 2 muscle fatigue 0.0292062872885048 0.0921377801270205 0.863363363363363 0.769230769230769 30.2 30 2 small otic vesicle 0.0292062872885048 0.0921377801270205 0.863363363363363 0.769230769230769 30.2 30 2 vestibular hair cell degeneration 0.0292062872885048 0.0921377801270205 0.863363363363363 0.769230769230769 30.2 30 2 small interparietal bone 0.0292062872885048 0.0921377801270205 0.863363363363363 0.769230769230769 30.2 30 2 increased circulating thyroid-stimulating hormone level 0.0292062872885048 0.0921377801270205 0.863363363363363 0.769230769230769 30.2 30 2 abnormal cranium morphology 1.73730672962038e-12 7.51573998248814e-11 0.862719062345928 0.76865671641791 30.2 30 2 abnormal neuron differentiation 1.28402491934976e-10 4.2586826491767e-09 0.861821643071643 0.767857142857143 30.2 30 2 short mandible 5.58463611201997e-06 6.7110059558694e-05 0.861821643071643 0.767857142857143 30.2 30 2 abnormal spatial learning 1.03804374456609e-14 6.14793765382894e-13 0.860715009488016 0.766871165644172 30.2 30 2 abnormal bone structure 3.8068714522549e-17 3.03263809669422e-15 0.860679332181923 0.766839378238342 30.2 30 2 abnormal retina morphology 1.6594487392558e-18 1.44837850487677e-16 0.860485485485486 0.766666666666667 30.2 30 2 gastrointestinal hemorrhage 0.000945661128384322 0.00595527103001519 0.860485485485486 0.766666666666667 30.2 30 2 increased metastatic potential 0.000945661128384322 0.00595527103001519 0.860485485485486 0.766666666666667 30.2 30 2 abnormal response to new environment 0.000945661128384322 0.00595527103001519 0.860485485485486 0.766666666666667 30.2 30 2 liver hemorrhage 0.000945661128384322 0.00595527103001519 0.860485485485486 0.766666666666667 30.2 30 2 decreased leukocyte cell number 1.47077052373347e-12 6.53311013890536e-11 0.860212402183205 0.766423357664234 30.2 30 2 cyanosis 6.23291928082081e-17 4.84512084720055e-15 0.859316347597598 0.765625 30.2 30 2 decreased circulating LDL cholesterol level 1.44488230431878e-06 1.98024503140109e-05 0.859316347597598 0.765625 30.2 30 2 decreased caudal vertebrae number 1.44488230431878e-06 1.98024503140109e-05 0.859316347597598 0.765625 30.2 30 2 abnormal osteoclast physiology 1.44488230431878e-06 1.98024503140109e-05 0.859316347597598 0.765625 30.2 30 2 abnormal tooth morphology 1.44488230431878e-06 1.98024503140109e-05 0.859316347597598 0.765625 30.2 30 2 perinatal lethality, incomplete penetrance 1.18438223348693e-19 1.15535325717598e-17 0.859161152302745 0.765486725663717 30.2 30 2 neonatal lethality, incomplete penetrance 2.24847465921366e-22 2.94372669199683e-20 0.859046546546547 0.765384615384615 30.2 30 2 hydroencephaly 1.0837076378108e-10 3.74405937368661e-09 0.858858858858859 0.765217391304348 30.2 30 2 abnormal nervous system physiology 1.0837076378108e-10 3.74405937368661e-09 0.858858858858859 0.765217391304348 30.2 30 2 decreased circulating alanine transaminase level 7.36419713472689e-07 1.11859758042491e-05 0.858284755343579 0.764705882352941 30.2 30 2 decreased mean corpuscular hemoglobin 7.36419713472689e-07 1.11859758042491e-05 0.858284755343579 0.764705882352941 30.2 30 2 lung hemorrhage 0.000469148343884884 0.00329662854636624 0.858284755343579 0.764705882352941 30.2 30 2 abnormal spleen red pulp morphology 0.000469148343884884 0.00329662854636624 0.858284755343579 0.764705882352941 30.2 30 2 abnormal brown adipose tissue morphology 0.000469148343884884 0.00329662854636624 0.858284755343579 0.764705882352941 30.2 30 2 abnormal cranial suture morphology 0.0136849977004801 0.0514221023866228 0.858284755343579 0.764705882352941 30.2 30 2 absence seizures 0.0136849977004801 0.0514221023866228 0.858284755343579 0.764705882352941 30.2 30 2 abnormal survival 0.0136849977004801 0.0514221023866228 0.858284755343579 0.764705882352941 30.2 30 2 decreased body fat mass 0.0136849977004801 0.0514221023866228 0.858284755343579 0.764705882352941 30.2 30 2 increased or absent threshold for auditory brainstem response 1.34750539046672e-24 2.31166873019722e-22 0.858284755343579 0.764705882352941 30.2 30 2 abnormal gluconeogenesis 1.81295094004079e-05 0.000188691023571191 0.858284755343579 0.764705882352941 30.2 30 2 increased kidney weight 1.81295094004079e-05 0.000188691023571191 0.858284755343579 0.764705882352941 30.2 30 2 abnormal enzyme/coenzyme activity 5.38080653698371e-14 3.04199005926067e-12 0.857864233660412 0.764331210191083 30.2 30 2 abnormal forebrain development 3.75764134640374e-07 6.46860404787495e-06 0.857367784451118 0.763888888888889 30.2 30 2 abnormal contextual conditioning behavior 9.17996997146044e-06 0.000103560885732462 0.857084357084357 0.763636363636364 30.2 30 2 decreased circulating glucose level 1.34961418654602e-23 2.09822830564577e-21 0.856864929445575 0.763440860215054 30.2 30 2 decreased neuron apoptosis 0.000233984668024447 0.00180197170808301 0.856547336810495 0.763157894736842 30.2 30 2 hyporesponsive to tactile stimuli 0.000233984668024447 0.00180197170808301 0.856547336810495 0.763157894736842 30.2 30 2 increased hemoglobin content 4.65729494560262e-06 5.65212366642966e-05 0.856046724690792 0.76271186440678 30.2 30 2 abnormal retinal pigment epithelium morphology 9.81253809883444e-08 1.92194397801974e-06 0.855808933933934 0.7625 30.2 30 2 decreased exploration in new environment 5.02078583048428e-08 1.04076706277747e-06 0.855140855140855 0.761904761904762 30.2 30 2 disheveled coat 0.000117200543272676 0.000981603876736642 0.855140855140855 0.761904761904762 30.2 30 2 trunk curl 0.00655027257482017 0.0283469885476634 0.855140855140855 0.761904761904762 30.2 30 2 abnormal clavicle morphology 0.00655027257482017 0.0283469885476634 0.855140855140855 0.761904761904762 30.2 30 2 decreased vocalization 0.00655027257482017 0.0283469885476634 0.855140855140855 0.761904761904762 30.2 30 2 postnatal lethality, complete penetrance 1.02668619345035e-31 3.51209406257674e-29 0.854863931288802 0.761658031088083 30.2 30 2 thymus hypoplasia 3.29661445871057e-12 1.37042734832487e-10 0.853978978978979 0.760869565217391 30.2 30 2 abnormal inner ear morphology 5.89130512877373e-05 0.000533865992999077 0.853978978978979 0.760869565217391 30.2 30 2 abnormal forelimb morphology 5.89130512877373e-05 0.000533865992999077 0.853978978978979 0.760869565217391 30.2 30 2 abnormal allantois morphology 5.89130512877373e-05 0.000533865992999077 0.853978978978979 0.760869565217391 30.2 30 2 atrial septal defect 5.89130512877373e-05 0.000533865992999077 0.853978978978979 0.760869565217391 30.2 30 2 abnormal skeletal muscle fiber morphology 6.13833507198166e-07 9.72554680990726e-06 0.853635325466311 0.76056338028169 30.2 30 2 cataract 7.63239485543624e-11 2.71222602898538e-09 0.853374035192217 0.760330578512397 30.2 30 2 abnormal neurocranium morphology 3.1317269116336e-07 5.52494375367985e-06 0.853003003003003 0.76 30.2 30 2 decreased heart rate 3.46477025570283e-09 9.16874043729872e-08 0.853003003003003 0.76 30.2 30 2 kidney inflammation 2.97019068964935e-05 0.000289172185538269 0.853003003003003 0.76 30.2 30 2 spontaneous skin ulceration 0.00318029852526599 0.0161872796263447 0.853003003003003 0.76 30.2 30 2 increased pre-B cell number 0.00318029852526599 0.0161872796263447 0.853003003003003 0.76 30.2 30 2 abnormal keratinocyte physiology 0.00318029852526599 0.0161872796263447 0.853003003003003 0.76 30.2 30 2 abnormal preimplantation embryo development 0.00318029852526599 0.0161872796263447 0.853003003003003 0.76 30.2 30 2 diluted coat color 1.50125157161148e-05 0.000159247901253031 0.852171616060505 0.759259259259259 30.2 30 2 abnormal mandible morphology 1.50125157161148e-05 0.000159247901253031 0.852171616060505 0.759259259259259 30.2 30 2 abnormal long bone epiphyseal plate proliferative zone 1.50125157161148e-05 0.000159247901253031 0.852171616060505 0.759259259259259 30.2 30 2 axon degeneration 1.50125157161148e-05 0.000159247901253031 0.852171616060505 0.759259259259259 30.2 30 2 abnormal lipid level 8.17616629474468e-08 1.62057479348027e-06 0.85192119830674 0.759036144578313 30.2 30 2 postnatal lethality, incomplete penetrance 3.56704287644961e-45 1.97178203448187e-42 0.851659317768473 0.758802816901408 30.2 30 2 abnormal spleen morphology 8.46406003621219e-15 5.13520715611654e-13 0.851454903179041 0.758620689655172 30.2 30 2 cochlear ganglion degeneration 7.6043789078091e-06 8.83920211830614e-05 0.851454903179041 0.758620689655172 30.2 30 2 lordosis 0.00155999330084295 0.00909843689530327 0.851454903179041 0.758620689655172 30.2 30 2 abnormal spinal nerve morphology 0.00155999330084295 0.00909843689530327 0.851454903179041 0.758620689655172 30.2 30 2 abnormal embryonic erythropoiesis 0.00155999330084295 0.00909843689530327 0.851454903179041 0.758620689655172 30.2 30 2 decreased bone strength 0.00155999330084295 0.00909843689530327 0.851454903179041 0.758620689655172 30.2 30 2 increased double-positive T cell number 0.00155999330084295 0.00909843689530327 0.851454903179041 0.758620689655172 30.2 30 2 increased retinal apoptosis 0.00155999330084295 0.00909843689530327 0.851454903179041 0.758620689655172 30.2 30 2 abnormal B cell differentiation 2.14173312253736e-08 4.86535264138054e-07 0.851029601029601 0.758241758241758 30.2 30 2 increased tumor incidence 6.3727819086396e-11 2.29743405764362e-09 0.850830669379056 0.758064516129032 30.2 30 2 abnormal neuron morphology 5.62550986582012e-09 1.4200201280226e-07 0.8502821002821 0.757575757575758 30.2 30 2 abnormal skin morphology 1.96167372322174e-06 2.65921710436734e-05 0.8502821002821 0.757575757575758 30.2 30 2 decreased systemic arterial blood pressure 0.000771126588686272 0.00504120207452589 0.8502821002821 0.757575757575758 30.2 30 2 dilated heart atrium 0.000771126588686272 0.00504120207452589 0.8502821002821 0.757575757575758 30.2 30 2 increased osteoblast cell number 0.000771126588686272 0.00504120207452589 0.8502821002821 0.757575757575758 30.2 30 2 decreased total body fat amount 7.42762629535712e-27 1.8442302911516e-24 0.85018027009045 0.75748502994012 30.2 30 2 enlarged spleen 2.86402420804057e-23 4.31773346515207e-21 0.849573531865199 0.756944444444444 30.2 30 2 abnormal vocalization 0.00038347726867113 0.0027649266835346 0.849362876389903 0.756756756756757 30.2 30 2 skin inflammation 0.00038347726867113 0.0027649266835346 0.849362876389903 0.756756756756757 30.2 30 2 abnormal developmental patterning 1.32666582777516e-07 2.53852403583901e-06 0.84862301325716 0.75609756097561 30.2 30 2 lethality at weaning, incomplete penetrance 0.000191621832724822 0.00151802327676113 0.84862301325716 0.75609756097561 30.2 30 2 decreased bone mineral density 2.05655875012801e-21 2.37939064695043e-19 0.848108446792657 0.755639097744361 30.2 30 2 abnormal ovarian follicle morphology 9.61305217227333e-05 0.000817520248838629 0.848014681348015 0.755555555555556 30.2 30 2 abnormal cell migration 9.61305217227333e-05 0.000817520248838629 0.848014681348015 0.755555555555556 30.2 30 2 cardiomyopathy 9.61305217227333e-05 0.000817520248838629 0.848014681348015 0.755555555555556 30.2 30 2 increased T cell derived lymphoma incidence 4.83839523291534e-05 0.0004490861246969 0.84750566893424 0.755102040816326 30.2 30 2 azoospermia 2.6152916564709e-13 1.27559568538654e-11 0.847073488582923 0.754716981132076 30.2 30 2 extramedullary hematopoiesis 2.39482800210932e-09 6.61903850582992e-08 0.847073488582923 0.754716981132076 30.2 30 2 abnormal coat/ hair morphology 2.44198410065167e-05 0.000245849712888871 0.847073488582923 0.754716981132076 30.2 30 2 decreased bone marrow cell number 8.23884789827152e-07 1.22719366149404e-05 0.845623020280555 0.753424657534247 30.2 30 2 seminiferous tubule degeneration 8.23884789827152e-07 1.22719366149404e-05 0.845623020280555 0.753424657534247 30.2 30 2 polyuria 4.2012797337828e-07 6.92098234290379e-06 0.845423345423346 0.753246753246753 30.2 30 2 postnatal lethality 1.11833960164664e-13 5.85656791388633e-12 0.8451599189551 0.753012048192771 30.2 30 2 abnormal vertebrae morphology 1.9811909991715e-09 5.50638280495989e-08 0.844353527839766 0.752293577981651 30.2 30 2 abnormal bone mineralization 2.68315267638244e-10 8.72463043464225e-09 0.844098230461867 0.752066115702479 30.2 30 2 abnormal limb bone morphology 0.00062372421820475 0.0041428945067672 0.841779279279279 0.75 30.2 30 2 renal hypoplasia 0.00062372421820475 0.0041428945067672 0.841779279279279 0.75 30.2 30 2 short radius 0.00062372421820475 0.0041428945067672 0.841779279279279 0.75 30.2 30 2 epidermal hyperplasia 1.01134976782108e-05 0.000113321285921393 0.841779279279279 0.75 30.2 30 2 abnormal long bone epiphyseal plate morphology 1.01134976782108e-05 0.000113321285921393 0.841779279279279 0.75 30.2 30 2 abnormal intestinal epithelium morphology 7.83481839059617e-05 0.000686236293894647 0.841779279279279 0.75 30.2 30 2 abnormal phalanx morphology 7.83481839059617e-05 0.000686236293894647 0.841779279279279 0.75 30.2 30 2 abnormal vertebral body morphology 0.00125692179139778 0.00754304693872613 0.841779279279279 0.75 30.2 30 2 neonatal lethality 0.00125692179139778 0.00754304693872613 0.841779279279279 0.75 30.2 30 2 decreased susceptibility to parasitic infection 0.00125692179139778 0.00754304693872613 0.841779279279279 0.75 30.2 30 2 abnormal adrenal gland morphology 0.00521558622454501 0.0236747641123279 0.841779279279279 0.75 30.2 30 2 decreased body height 0.00521558622454501 0.0236747641123279 0.841779279279279 0.75 30.2 30 2 abnormal body weight 0.00521558622454501 0.0236747641123279 0.841779279279279 0.75 30.2 30 2 hemolytic anemia 0.00521558622454501 0.0236747641123279 0.841779279279279 0.75 30.2 30 2 abnormal vasodilation 0.00521558622454501 0.0236747641123279 0.841779279279279 0.75 30.2 30 2 abnormal sensory capabilities/reflexes/nociception 0.00521558622454501 0.0236747641123279 0.841779279279279 0.75 30.2 30 2 prolonged QT interval 0.00521558622454501 0.0236747641123279 0.841779279279279 0.75 30.2 30 2 abnormal tumor morphology 0.00521558622454501 0.0236747641123279 0.841779279279279 0.75 30.2 30 2 increased body temperature 0.00521558622454501 0.0236747641123279 0.841779279279279 0.75 30.2 30 2 waved hair 0.0107914294324968 0.043420712628428 0.841779279279279 0.75 30.2 30 2 increased urine glucose level 0.0107914294324968 0.043420712628428 0.841779279279279 0.75 30.2 30 2 increased mammary adenocarcinoma incidence 0.0107914294324968 0.043420712628428 0.841779279279279 0.75 30.2 30 2 abnormal lens epithelium morphology 0.0107914294324968 0.043420712628428 0.841779279279279 0.75 30.2 30 2 abnormal postnatal subventricular zone morphology 0.0107914294324968 0.043420712628428 0.841779279279279 0.75 30.2 30 2 dilated vasculature 0.0107914294324968 0.043420712628428 0.841779279279279 0.75 30.2 30 2 abnormal response to tactile stimuli 0.0107914294324968 0.043420712628428 0.841779279279279 0.75 30.2 30 2 abnormal induced retinal neovascularization 0.0107914294324968 0.043420712628428 0.841779279279279 0.75 30.2 30 2 abnormal sperm mitochondrial sheath morphology 0.0107914294324968 0.043420712628428 0.841779279279279 0.75 30.2 30 2 abnormal neuron proliferation 0.0107914294324968 0.043420712628428 0.841779279279279 0.75 30.2 30 2 abnormal heart electrocardiography waveform feature 0.0107914294324968 0.043420712628428 0.841779279279279 0.75 30.2 30 2 poor circulation 0.0226902288917831 0.0783508978418117 0.841779279279279 0.75 30.2 30 2 intraventricular hemorrhage 0.0226902288917831 0.0783508978418117 0.841779279279279 0.75 30.2 30 2 white spotting 0.0226902288917831 0.0783508978418117 0.841779279279279 0.75 30.2 30 2 increased intestinal adenocarcinoma incidence 0.0226902288917831 0.0783508978418117 0.841779279279279 0.75 30.2 30 2 decreased aggression towards mice 0.0226902288917831 0.0783508978418117 0.841779279279279 0.75 30.2 30 2 bowed tibia 0.0226902288917831 0.0783508978418117 0.841779279279279 0.75 30.2 30 2 increased thymus weight 0.0226902288917831 0.0783508978418117 0.841779279279279 0.75 30.2 30 2 abnormal wound healing 0.0226902288917831 0.0783508978418117 0.841779279279279 0.75 30.2 30 2 sepsis 0.0226902288917831 0.0783508978418117 0.841779279279279 0.75 30.2 30 2 decreased creatinine clearance 0.0226902288917831 0.0783508978418117 0.841779279279279 0.75 30.2 30 2 decreased liver cholesterol level 0.0226902288917831 0.0783508978418117 0.841779279279279 0.75 30.2 30 2 abnormal thoracic cage shape 0.0226902288917831 0.0783508978418117 0.841779279279279 0.75 30.2 30 2 decreased midbrain size 0.0226902288917831 0.0783508978418117 0.841779279279279 0.75 30.2 30 2 abnormal supraoccipital bone morphology 0.0488926312733546 0.132438456578514 0.841779279279279 0.75 30.2 30 2 abnormal esophagus morphology 0.0488926312733546 0.132438456578514 0.841779279279279 0.75 30.2 30 2 mesocardia 0.0488926312733546 0.132438456578514 0.841779279279279 0.75 30.2 30 2 abnormal enteric nervous system morphology 0.0488926312733546 0.132438456578514 0.841779279279279 0.75 30.2 30 2 increased growth rate 0.0488926312733546 0.132438456578514 0.841779279279279 0.75 30.2 30 2 abnormal AMPA-mediated synaptic currents 0.0488926312733546 0.132438456578514 0.841779279279279 0.75 30.2 30 2 small thyroid gland 0.0488926312733546 0.132438456578514 0.841779279279279 0.75 30.2 30 2 small intestinal inflammation 0.0488926312733546 0.132438456578514 0.841779279279279 0.75 30.2 30 2 abnormal vascular endothelial cell development 0.0488926312733546 0.132438456578514 0.841779279279279 0.75 30.2 30 2 absent ovary 0.0488926312733546 0.132438456578514 0.841779279279279 0.75 30.2 30 2 delayed somite formation 0.0488926312733546 0.132438456578514 0.841779279279279 0.75 30.2 30 2 vestibular saccular macula degeneration 0.0488926312733546 0.132438456578514 0.841779279279279 0.75 30.2 30 2 stria vascularis degeneration 0.0488926312733546 0.132438456578514 0.841779279279279 0.75 30.2 30 2 absent cochlear hair cells 0.0488926312733546 0.132438456578514 0.841779279279279 0.75 30.2 30 2 decreased cochlear nerve compound action potential 0.0488926312733546 0.132438456578514 0.841779279279279 0.75 30.2 30 2 small parietal bone 0.0488926312733546 0.132438456578514 0.841779279279279 0.75 30.2 30 2 abnormal palatine bone morphology 0.0488926312733546 0.132438456578514 0.841779279279279 0.75 30.2 30 2 abnormal somatic nervous system physiology 0.0488926312733546 0.132438456578514 0.841779279279279 0.75 30.2 30 2 abnormal aorta elastic tissue morphology 0.0488926312733546 0.132438456578514 0.841779279279279 0.75 30.2 30 2 decreased mammary gland epithelial cell proliferation 0.0488926312733546 0.132438456578514 0.841779279279279 0.75 30.2 30 2 increased fibrosarcoma incidence 0.0488926312733546 0.132438456578514 0.841779279279279 0.75 30.2 30 2 abnormal pulmonary valve cusp morphology 0.0488926312733546 0.132438456578514 0.841779279279279 0.75 30.2 30 2 abnormal colon goblet cell morphology 0.0488926312733546 0.132438456578514 0.841779279279279 0.75 30.2 30 2 abnormal bone marrow development 0.109887584537704 0.235947662095414 0.841779279279279 0.75 30.2 30 2 clubfoot 0.109887584537704 0.235947662095414 0.841779279279279 0.75 30.2 30 2 absent mammary gland 0.109887584537704 0.235947662095414 0.841779279279279 0.75 30.2 30 2 enlarged pituitary gland 0.109887584537704 0.235947662095414 0.841779279279279 0.75 30.2 30 2 abnormal vagus ganglion morphology 0.109887584537704 0.235947662095414 0.841779279279279 0.75 30.2 30 2 absent skin pigmentation 0.109887584537704 0.235947662095414 0.841779279279279 0.75 30.2 30 2 dermal cysts 0.109887584537704 0.235947662095414 0.841779279279279 0.75 30.2 30 2 unidirectional circling 0.109887584537704 0.235947662095414 0.841779279279279 0.75 30.2 30 2 poor grooming 0.109887584537704 0.235947662095414 0.841779279279279 0.75 30.2 30 2 abnormal erythrocyte cell number 0.109887584537704 0.235947662095414 0.841779279279279 0.75 30.2 30 2 abnormal atrial thrombosis 0.109887584537704 0.235947662095414 0.841779279279279 0.75 30.2 30 2 preneoplasia 0.109887584537704 0.235947662095414 0.841779279279279 0.75 30.2 30 2 abnormal thyroid physiology 0.109887584537704 0.235947662095414 0.841779279279279 0.75 30.2 30 2 head spot 0.109887584537704 0.235947662095414 0.841779279279279 0.75 30.2 30 2 decreased corneal stroma thickness 0.109887584537704 0.235947662095414 0.841779279279279 0.75 30.2 30 2 decreased susceptibility to age related obesity 0.109887584537704 0.235947662095414 0.841779279279279 0.75 30.2 30 2 liver failure 0.109887584537704 0.235947662095414 0.841779279279279 0.75 30.2 30 2 pulmonary interstitial fibrosis 0.109887584537704 0.235947662095414 0.841779279279279 0.75 30.2 30 2 abnormal ovary development 0.109887584537704 0.235947662095414 0.841779279279279 0.75 30.2 30 2 lymph node inflammation 0.109887584537704 0.235947662095414 0.841779279279279 0.75 30.2 30 2 abnormal skin development 0.109887584537704 0.235947662095414 0.841779279279279 0.75 30.2 30 2 abnormal miscarriage rate 0.109887584537704 0.235947662095414 0.841779279279279 0.75 30.2 30 2 abnormal lateral ganglionic eminence morphology 0.109887584537704 0.235947662095414 0.841779279279279 0.75 30.2 30 2 small frontal bone 0.109887584537704 0.235947662095414 0.841779279279279 0.75 30.2 30 2 abnormal hair follicle melanocyte morphology 0.109887584537704 0.235947662095414 0.841779279279279 0.75 30.2 30 2 absent cochlear microphonics 0.109887584537704 0.235947662095414 0.841779279279279 0.75 30.2 30 2 abnormal optic choroid morphology 0.109887584537704 0.235947662095414 0.841779279279279 0.75 30.2 30 2 abnormal choroid pigmentation 0.109887584537704 0.235947662095414 0.841779279279279 0.75 30.2 30 2 abnormal olfactory tract morphology 0.109887584537704 0.235947662095414 0.841779279279279 0.75 30.2 30 2 choroidal neovascularization 0.109887584537704 0.235947662095414 0.841779279279279 0.75 30.2 30 2 hypergranulosis 0.109887584537704 0.235947662095414 0.841779279279279 0.75 30.2 30 2 enlarged inguinal lymph nodes 0.109887584537704 0.235947662095414 0.841779279279279 0.75 30.2 30 2 impaired behavioral response to alcohol 0.109887584537704 0.235947662095414 0.841779279279279 0.75 30.2 30 2 abnormal meiotic spindle morphology 0.109887584537704 0.235947662095414 0.841779279279279 0.75 30.2 30 2 abnormal base-excision repair 0.109887584537704 0.235947662095414 0.841779279279279 0.75 30.2 30 2 abnormal sphingomyelin level 0.109887584537704 0.235947662095414 0.841779279279279 0.75 30.2 30 2 abnormal frontonasal prominence morphology 0.109887584537704 0.235947662095414 0.841779279279279 0.75 30.2 30 2 abnormal olfactory bulb glomerular layer morphology 0.109887584537704 0.235947662095414 0.841779279279279 0.75 30.2 30 2 increased caudal vertebrae number 0.109887584537704 0.235947662095414 0.841779279279279 0.75 30.2 30 2 abnormal circulating serum amyloid protein level 0.109887584537704 0.235947662095414 0.841779279279279 0.75 30.2 30 2 decreased quadriceps weight 0.109887584537704 0.235947662095414 0.841779279279279 0.75 30.2 30 2 anomalous pulmonary venous connection 0.109887584537704 0.235947662095414 0.841779279279279 0.75 30.2 30 2 myocardial trabeculae hypoplasia 0.109887584537704 0.235947662095414 0.841779279279279 0.75 30.2 30 2 sinoatrial block 0.109887584537704 0.235947662095414 0.841779279279279 0.75 30.2 30 2 abnormal visual evoked potential 0.109887584537704 0.235947662095414 0.841779279279279 0.75 30.2 30 2 abnormal stomach position or orientation 0.109887584537704 0.235947662095414 0.841779279279279 0.75 30.2 30 2 abnormal pulmonary acinus morphology 0.109887584537704 0.235947662095414 0.841779279279279 0.75 30.2 30 2 abnormal maxillary prominence morphology 0.109887584537704 0.235947662095414 0.841779279279279 0.75 30.2 30 2 abnormal branching involved in ureteric bud morphogenesis 0.109887584537704 0.235947662095414 0.841779279279279 0.75 30.2 30 2 abnormal kidney mesenchyme morphology 0.109887584537704 0.235947662095414 0.841779279279279 0.75 30.2 30 2 abnormal macrophage activation involved in immune response 0.109887584537704 0.235947662095414 0.841779279279279 0.75 30.2 30 2 absent Reichert's membrane 0.109887584537704 0.235947662095414 0.841779279279279 0.75 30.2 30 2 decreased cranium length 0.109887584537704 0.235947662095414 0.841779279279279 0.75 30.2 30 2 abnormal heart echocardiography feature 0.109887584537704 0.235947662095414 0.841779279279279 0.75 30.2 30 2 increased testis apoptosis 0.109887584537704 0.235947662095414 0.841779279279279 0.75 30.2 30 2 decreased white adipose tissue mass 0.109887584537704 0.235947662095414 0.841779279279279 0.75 30.2 30 2 abnormal seminal vesicle morphology 1.99659715497818e-05 0.000206938975958676 0.841779279279279 0.75 30.2 30 2 abnormal skin condition 3.9501661884237e-05 0.000379383721764631 0.841779279279279 0.75 30.2 30 2 abnormal brain wave pattern 3.9501661884237e-05 0.000379383721764631 0.841779279279279 0.75 30.2 30 2 decreased blood urea nitrogen level 0.000155855489365982 0.00125641150887123 0.841779279279279 0.75 30.2 30 2 lethality, incomplete penetrance 0.000155855489365982 0.00125641150887123 0.841779279279279 0.75 30.2 30 2 abnormal stria vascularis morphology 0.00254956910368155 0.0134087317157796 0.841779279279279 0.75 30.2 30 2 shortened head 0.00254956910368155 0.0134087317157796 0.841779279279279 0.75 30.2 30 2 lymphoid hyperplasia 0.00254956910368155 0.0134087317157796 0.841779279279279 0.75 30.2 30 2 abnormal respiration 0.00254956910368155 0.0134087317157796 0.841779279279279 0.75 30.2 30 2 corneal vascularization 0.00254956910368155 0.0134087317157796 0.841779279279279 0.75 30.2 30 2 abnormal liver morphology 3.25694098028774e-14 1.86244613527948e-12 0.840211720099988 0.748603351955307 30.2 30 2 impaired coordination 4.23155385134412e-26 9.56908200474409e-24 0.840157353885677 0.748554913294798 30.2 30 2 respiratory failure 3.38348607240539e-12 1.39114406696007e-10 0.839921046874689 0.748344370860927 30.2 30 2 abnormal lung morphology 6.90538722494169e-10 2.08207887539908e-08 0.839421354127236 0.747899159663866 30.2 30 2 infertility 5.10272567199609e-09 1.30855980506085e-07 0.839156913923269 0.747663551401869 30.2 30 2 small spleen 7.39915330447662e-08 1.47243150759085e-06 0.838695838695839 0.747252747252747 30.2 30 2 abnormal locomotor activation 7.39915330447662e-08 1.47243150759085e-06 0.838695838695839 0.747252747252747 30.2 30 2 abnormal placenta labyrinth morphology 5.54082989728218e-07 8.94987946070742e-06 0.838227467974303 0.746835443037975 30.2 30 2 abnormal limb morphology 1.08612250602455e-06 1.56169348770871e-05 0.838038038038038 0.746666666666667 30.2 30 2 atelectasis 2.13150894550069e-06 2.87378238587152e-05 0.837827263883602 0.746478873239437 30.2 30 2 internal hemorrhage 4.18854526682271e-06 5.19651189587107e-05 0.837591322665949 0.746268656716418 30.2 30 2 syndactyly 1.62491585302811e-05 0.000170547602717613 0.837023464142108 0.745762711864407 30.2 30 2 abnormal thoracic vertebrae morphology 1.62491585302811e-05 0.000170547602717613 0.837023464142108 0.745762711864407 30.2 30 2 decreased circulating calcium level 3.20935425397451e-05 0.000311238546072576 0.836677586677587 0.745454545454545 30.2 30 2 kinked tail 1.58943219971392e-08 3.76544056836988e-07 0.836277453924513 0.745098039215686 30.2 30 2 hepatic necrosis 0.000126081661344796 0.00103850375031517 0.835809213468788 0.74468085106383 30.2 30 2 reduced male fertility 3.84032562998464e-17 3.03263809669422e-15 0.835598814673705 0.744493392070485 30.2 30 2 abnormal double-strand DNA break repair 0.000250991611972236 0.00192629961407036 0.835253858509672 0.744186046511628 30.2 30 2 increased circulating insulin level 1.87535558040128e-12 8.04301207973825e-11 0.834764451951952 0.74375 30.2 30 2 increased urine protein level 8.85295291081271e-07 1.30306037666548e-05 0.834584584584585 0.743589743589744 30.2 30 2 abnormal heart ventricle morphology 8.85295291081271e-07 1.30306037666548e-05 0.834584584584585 0.743589743589744 30.2 30 2 abnormal heart looping 0.000501474337991104 0.00350890974895322 0.834584584584585 0.743589743589744 30.2 30 2 increased hepatocyte apoptosis 0.000501474337991104 0.00350890974895322 0.834584584584585 0.743589743589744 30.2 30 2 failure of heart looping 0.000501474337991104 0.00350890974895322 0.834584584584585 0.743589743589744 30.2 30 2 decreased circulating cholesterol level 5.59121609572978e-14 3.12542697486019e-12 0.834112801325916 0.743169398907104 30.2 30 2 spleen hypoplasia 1.29850300328737e-08 3.09093418246634e-07 0.833762333762334 0.742857142857143 30.2 30 2 abnormal liver development 0.00100636091887817 0.00618104391533197 0.833762333762334 0.742857142857143 30.2 30 2 holoprosencephaly 0.00100636091887817 0.00618104391533197 0.833762333762334 0.742857142857143 30.2 30 2 decreased circulating thyroxine level 0.00100636091887817 0.00618104391533197 0.833762333762334 0.742857142857143 30.2 30 2 abnormal pulmonary alveolus morphology 2.53128436743568e-08 5.54763864669273e-07 0.833444830969583 0.742574257425743 30.2 30 2 abnormal postnatal growth/weight/body size 0.00203058436001653 0.0111626046310301 0.832727889179502 0.741935483870968 30.2 30 2 decreased neuronal precursor cell number 0.00203058436001653 0.0111626046310301 0.832727889179502 0.741935483870968 30.2 30 2 abnormal T cell proliferation 0.00203058436001653 0.0111626046310301 0.832727889179502 0.741935483870968 30.2 30 2 abnormal intestine physiology 0.00203058436001653 0.0111626046310301 0.832727889179502 0.741935483870968 30.2 30 2 increased startle reflex 1.88188895348372e-07 3.41816461802324e-06 0.832321085130074 0.741573033707865 30.2 30 2 abnormal muscle physiology 1.88188895348372e-07 3.41816461802324e-06 0.832321085130074 0.741573033707865 30.2 30 2 reduced long term potentiation 5.43593945160298e-09 1.37978565161861e-07 0.831758097383097 0.741071428571429 30.2 30 2 abnormal cochlea morphology 5.12979132648081e-05 0.000470861842236937 0.831386942498054 0.740740740740741 30.2 30 2 abnormal small intestine morphology 5.12979132648081e-05 0.000470861842236937 0.831386942498054 0.740740740740741 30.2 30 2 decreased tumor growth/size 5.12979132648081e-05 0.000470861842236937 0.831386942498054 0.740740740740741 30.2 30 2 rectal prolapse 0.00412542703776844 0.0196778518819731 0.831386942498054 0.740740740740741 30.2 30 2 abnormal brain commissure morphology 0.00412542703776844 0.0196778518819731 0.831386942498054 0.740740740740741 30.2 30 2 cryptorchism 0.00412542703776844 0.0196778518819731 0.831386942498054 0.740740740740741 30.2 30 2 abnormal palate morphology 0.00412542703776844 0.0196778518819731 0.831386942498054 0.740740740740741 30.2 30 2 female infertility 2.66731190648915e-19 2.50375032731764e-17 0.831230666756983 0.740601503759398 30.2 30 2 decreased litter size 2.99449643380223e-20 3.10367078295127e-18 0.830795208019407 0.740213523131673 30.2 30 2 increased circulating chloride level 0.000101555927791339 0.000859252960479444 0.830555555555555 0.74 30.2 30 2 abnormal fertility/fecundity 2.7609084192083e-06 3.63271924438386e-05 0.830248056275454 0.73972602739726 30.2 30 2 anemia 1.76904062703104e-15 1.17346361593059e-13 0.829810853507536 0.739336492890995 30.2 30 2 abnormal spermatogenesis 1.14701338260982e-13 5.944157894254e-12 0.82957957957958 0.739130434782609 30.2 30 2 abnormal testis morphology 4.42483542074546e-09 1.14059876778283e-07 0.82957957957958 0.739130434782609 30.2 30 2 abnormal lymphocyte physiology 0.000201580021288556 0.00158303630565041 0.82957957957958 0.739130434782609 30.2 30 2 fragile skeleton 0.00845646990677519 0.0354729660929229 0.82957957957958 0.739130434782609 30.2 30 2 abnormal pulmonary artery morphology 0.00845646990677519 0.0354729660929229 0.82957957957958 0.739130434782609 30.2 30 2 abnormal cranial nerve morphology 0.00845646990677519 0.0354729660929229 0.82957957957958 0.739130434782609 30.2 30 2 hypotension 0.00845646990677519 0.0354729660929229 0.82957957957958 0.739130434782609 30.2 30 2 abnormal cochlear ganglion morphology 0.00845646990677519 0.0354729660929229 0.82957957957958 0.739130434782609 30.2 30 2 abnormal sacral vertebrae morphology 0.00845646990677519 0.0354729660929229 0.82957957957958 0.739130434782609 30.2 30 2 abnormal B cell morphology 0.00845646990677519 0.0354729660929229 0.82957957957958 0.739130434782609 30.2 30 2 abnormal ulna morphology 0.00845646990677519 0.0354729660929229 0.82957957957958 0.739130434782609 30.2 30 2 increased lymphocyte cell number 5.41747673108186e-06 6.52589509373663e-05 0.82957957957958 0.739130434782609 30.2 30 2 neonatal lethality, complete penetrance 1.05892283293771e-31 3.51209406257674e-29 0.829472564669933 0.739035087719298 30.2 30 2 abnormal cartilage morphology 0.000401354557544502 0.00287300564573223 0.828417703417703 0.738095238095238 30.2 30 2 abnormal gait 9.40055976152141e-22 1.16919462033923e-19 0.828158255342721 0.737864077669903 30.2 30 2 abnormal maternal nurturing 2.09438522563026e-05 0.000215280299535342 0.827979618963225 0.737704918032787 30.2 30 2 abnormal motor coordination/ balance 6.35709087796343e-08 1.30150317357482e-06 0.827607910941244 0.737373737373737 30.2 30 2 alopecia 1.23912626499994e-07 2.3986977308851e-06 0.827011221748064 0.736842105263158 30.2 30 2 decreased birth weight 1.23912626499994e-07 2.3986977308851e-06 0.827011221748064 0.736842105263158 30.2 30 2 incomplete somite formation 0.000802056550481835 0.00520917929327301 0.827011221748064 0.736842105263158 30.2 30 2 abnormal reproductive system physiology 0.000802056550481835 0.00520917929327301 0.827011221748064 0.736842105263158 30.2 30 2 abnormal nail morphology 0.0175443496940497 0.063850138791439 0.827011221748064 0.736842105263158 30.2 30 2 small superior vagus ganglion 0.0175443496940497 0.063850138791439 0.827011221748064 0.736842105263158 30.2 30 2 thin dermal layer 0.0175443496940497 0.063850138791439 0.827011221748064 0.736842105263158 30.2 30 2 unresponsive to tactile stimuli 0.0175443496940497 0.063850138791439 0.827011221748064 0.736842105263158 30.2 30 2 delayed sexual maturation 0.0175443496940497 0.063850138791439 0.827011221748064 0.736842105263158 30.2 30 2 increased susceptibility to ischemic brain injury 0.0175443496940497 0.063850138791439 0.827011221748064 0.736842105263158 30.2 30 2 abnormal digestive system development 0.0175443496940497 0.063850138791439 0.827011221748064 0.736842105263158 30.2 30 2 oliguria 0.0175443496940497 0.063850138791439 0.827011221748064 0.736842105263158 30.2 30 2 abnormal cochlear inner hair cell morphology 0.0175443496940497 0.063850138791439 0.827011221748064 0.736842105263158 30.2 30 2 absent amnion 0.0175443496940497 0.063850138791439 0.827011221748064 0.736842105263158 30.2 30 2 eyelids fail to open 0.0175443496940497 0.063850138791439 0.827011221748064 0.736842105263158 30.2 30 2 decreased liver regeneration 0.0175443496940497 0.063850138791439 0.827011221748064 0.736842105263158 30.2 30 2 decreased circulating magnesium level 0.0175443496940497 0.063850138791439 0.827011221748064 0.736842105263158 30.2 30 2 decreased susceptibility to weight gain 0.0175443496940497 0.063850138791439 0.827011221748064 0.736842105263158 30.2 30 2 shortened RR interval 0.0175443496940497 0.063850138791439 0.827011221748064 0.736842105263158 30.2 30 2 thin interventricular septum 0.0175443496940497 0.063850138791439 0.827011221748064 0.736842105263158 30.2 30 2 right-sided stomach 0.0175443496940497 0.063850138791439 0.827011221748064 0.736842105263158 30.2 30 2 abnormal neuromuscular synapse morphology 4.37275989251875e-06 5.39813411049151e-05 0.826190774107441 0.736111111111111 30.2 30 2 cochlear outer hair cell degeneration 4.37275989251875e-06 5.39813411049151e-05 0.826190774107441 0.736111111111111 30.2 30 2 abnormal pancreatic islet morphology 8.15153057578858e-05 0.000708983647107486 0.825896651368349 0.735849056603774 30.2 30 2 impaired synaptic plasticity 0.00160995504646791 0.00930258577953291 0.82527380321498 0.735294117647059 30.2 30 2 abnormal vision 0.00160995504646791 0.00930258577953291 0.82527380321498 0.735294117647059 30.2 30 2 decreased startle reflex 5.66458087620643e-09 1.4200201280226e-07 0.824991658324992 0.735042735042735 30.2 30 2 insulin resistance 6.2701162392193e-10 1.93750486274012e-08 0.824773637273637 0.734848484848485 30.2 30 2 organ of Corti degeneration 0.000161326055964817 0.00128210403901751 0.824600110314396 0.73469387755102 30.2 30 2 increased circulating LDL cholesterol level 0.000161326055964817 0.00128210403901751 0.824600110314396 0.73469387755102 30.2 30 2 decreased urine osmolality 0.000161326055964817 0.00128210403901751 0.824600110314396 0.73469387755102 30.2 30 2 abnormal lens morphology 1.21664156513894e-09 3.47861596929094e-08 0.824242210960961 0.734375 30.2 30 2 respiratory distress 1.68107088331728e-12 7.33625231973988e-11 0.823938099949661 0.734104046242775 30.2 30 2 decreased insulin secretion 3.80619488019645e-07 6.49244247533236e-06 0.823073073073073 0.733333333333333 30.2 30 2 macrocytosis 0.037027675484535 0.112799152234824 0.823073073073073 0.733333333333333 30.2 30 2 abnormal enteric neuron morphology 0.037027675484535 0.112799152234824 0.823073073073073 0.733333333333333 30.2 30 2 vagina atresia 0.037027675484535 0.112799152234824 0.823073073073073 0.733333333333333 30.2 30 2 abnormal prostate gland morphology 0.037027675484535 0.112799152234824 0.823073073073073 0.733333333333333 30.2 30 2 hyperpigmentation 0.037027675484535 0.112799152234824 0.823073073073073 0.733333333333333 30.2 30 2 abnormal pup retrieval 0.037027675484535 0.112799152234824 0.823073073073073 0.733333333333333 30.2 30 2 abnormal trophectoderm morphology 0.037027675484535 0.112799152234824 0.823073073073073 0.733333333333333 30.2 30 2 abnormal energy homeostasis 0.037027675484535 0.112799152234824 0.823073073073073 0.733333333333333 30.2 30 2 abnormal cerebral aqueduct morphology 0.037027675484535 0.112799152234824 0.823073073073073 0.733333333333333 30.2 30 2 abnormal Muller cell morphology 0.037027675484535 0.112799152234824 0.823073073073073 0.733333333333333 30.2 30 2 ostium primum atrial septal defect 0.037027675484535 0.112799152234824 0.823073073073073 0.733333333333333 30.2 30 2 bicuspid aortic valve 0.037027675484535 0.112799152234824 0.823073073073073 0.733333333333333 30.2 30 2 small testis 9.17207324198951e-19 8.14840435337461e-17 0.821446446446446 0.731884057971015 30.2 30 2 increased tumor growth/size 0.000637050810728163 0.00421453162682528 0.821248077345638 0.731707317073171 30.2 30 2 short ulna 0.000637050810728163 0.00421453162682528 0.821248077345638 0.731707317073171 30.2 30 2 decreased cardiac muscle contractility 6.52387232859312e-08 1.32474550345922e-06 0.820195195195195 0.730769230769231 30.2 30 2 decreased IgA level 0.000128745744744406 0.00105869434727838 0.820195195195195 0.730769230769231 30.2 30 2 abnormal kidney cortex morphology 0.00660385120135516 0.0283469885476634 0.820195195195195 0.730769230769231 30.2 30 2 abnormal Schwann cell morphology 0.00660385120135516 0.0283469885476634 0.820195195195195 0.730769230769231 30.2 30 2 increased susceptibility to otitis media 0.00660385120135516 0.0283469885476634 0.820195195195195 0.730769230769231 30.2 30 2 abnormal erythrocyte osmotic lysis 0.00660385120135516 0.0283469885476634 0.820195195195195 0.730769230769231 30.2 30 2 hyperactivity 1.84233674072954e-24 3.05520842837649e-22 0.8198461264499 0.730458221024259 30.2 30 2 abnormal respiratory electron transport chain 0.00127239098194552 0.0076266808857578 0.819028487947407 0.72972972972973 30.2 30 2 hypoactivity 1.20176347646113e-24 2.17081996742538e-22 0.818706637672155 0.729442970822281 30.2 30 2 circling 1.1637790650402e-06 1.66853050391211e-05 0.81867161278926 0.729411764705882 30.2 30 2 abnormal lymph node morphology 0.000254594869833967 0.00193080713021949 0.818396521521522 0.729166666666667 30.2 30 2 abnormal action potential 1.08168942870939e-05 0.000119586775729538 0.817728442728443 0.728571428571429 30.2 30 2 increased sensitivity to induced morbidity/mortality 1.12344804790121e-12 5.081049125735e-11 0.81737987987988 0.728260869565217 30.2 30 2 seizures 2.17658130966193e-08 4.92204182525823e-07 0.817165850060587 0.728070175438597 30.2 30 2 abnormal motor capabilities/coordination/movement 1.9378136253533e-09 5.41608021692845e-08 0.816270816270816 0.727272727272727 30.2 30 2 deafness 1.98000821903757e-07 3.55615194574438e-06 0.816270816270816 0.727272727272727 30.2 30 2 abnormal tail morphology 2.11795970168282e-05 0.000217254629193238 0.816270816270816 0.727272727272727 30.2 30 2 hypertension 0.000504687938922245 0.0035116398547387 0.816270816270816 0.727272727272727 30.2 30 2 abnormal myelopoiesis 0.000504687938922245 0.0035116398547387 0.816270816270816 0.727272727272727 30.2 30 2 cochlear hair cell degeneration 0.000504687938922245 0.0035116398547387 0.816270816270816 0.727272727272727 30.2 30 2 embryonic lethality, incomplete penetrance 0.000504687938922245 0.0035116398547387 0.816270816270816 0.727272727272727 30.2 30 2 abnormal tooth development 0.00255237566529513 0.0134087317157796 0.816270816270816 0.727272727272727 30.2 30 2 belly spot 0.00255237566529513 0.0134087317157796 0.816270816270816 0.727272727272727 30.2 30 2 abnormal ovarian folliculogenesis 0.00255237566529513 0.0134087317157796 0.816270816270816 0.727272727272727 30.2 30 2 abnormal skeleton physiology 0.00255237566529513 0.0134087317157796 0.816270816270816 0.727272727272727 30.2 30 2 head tossing 0.00255237566529513 0.0134087317157796 0.816270816270816 0.727272727272727 30.2 30 2 decreased sensitivity to xenobiotic induced morbidity/mortality 0.00255237566529513 0.0134087317157796 0.816270816270816 0.727272727272727 30.2 30 2 abnormal abdominal fat pad morphology 0.013542120449959 0.0510781267919226 0.816270816270816 0.727272727272727 30.2 30 2 abnormal long bone epiphysis morphology 0.013542120449959 0.0510781267919226 0.816270816270816 0.727272727272727 30.2 30 2 abnormal tail movements 0.013542120449959 0.0510781267919226 0.816270816270816 0.727272727272727 30.2 30 2 increased myocardial infarction size 0.013542120449959 0.0510781267919226 0.816270816270816 0.727272727272727 30.2 30 2 abnormal tracheal cartilage morphology 0.013542120449959 0.0510781267919226 0.816270816270816 0.727272727272727 30.2 30 2 abnormal female reproductive system physiology 0.013542120449959 0.0510781267919226 0.816270816270816 0.727272727272727 30.2 30 2 abnormal blood-brain barrier function 0.013542120449959 0.0510781267919226 0.816270816270816 0.727272727272727 30.2 30 2 abnormal temporal bone morphology 0.013542120449959 0.0510781267919226 0.816270816270816 0.727272727272727 30.2 30 2 abnormal sperm midpiece morphology 0.013542120449959 0.0510781267919226 0.816270816270816 0.727272727272727 30.2 30 2 rough coat 0.013542120449959 0.0510781267919226 0.816270816270816 0.727272727272727 30.2 30 2 increased bone volume 0.013542120449959 0.0510781267919226 0.816270816270816 0.727272727272727 30.2 30 2 abnormal ear position 0.0802335472041678 0.201698785922554 0.816270816270816 0.727272727272727 30.2 30 2 absent semicircular canals 0.0802335472041678 0.201698785922554 0.816270816270816 0.727272727272727 30.2 30 2 abnormal thrombopoiesis 0.0802335472041678 0.201698785922554 0.816270816270816 0.727272727272727 30.2 30 2 increased mast cell number 0.0802335472041678 0.201698785922554 0.816270816270816 0.727272727272727 30.2 30 2 enlarged cranium 0.0802335472041678 0.201698785922554 0.816270816270816 0.727272727272727 30.2 30 2 abnormal stomach epithelium morphology 0.0802335472041678 0.201698785922554 0.816270816270816 0.727272727272727 30.2 30 2 abnormal food preference 0.0802335472041678 0.201698785922554 0.816270816270816 0.727272727272727 30.2 30 2 impaired myelopoiesis 0.0802335472041678 0.201698785922554 0.816270816270816 0.727272727272727 30.2 30 2 abnormal vestibular ganglion morphology 0.0802335472041678 0.201698785922554 0.816270816270816 0.727272727272727 30.2 30 2 decreased post-tetanic potentiation 0.0802335472041678 0.201698785922554 0.816270816270816 0.727272727272727 30.2 30 2 pulmonary hypertension 0.0802335472041678 0.201698785922554 0.816270816270816 0.727272727272727 30.2 30 2 abnormal lymph circulation 0.0802335472041678 0.201698785922554 0.816270816270816 0.727272727272727 30.2 30 2 abnormal ureter development 0.0802335472041678 0.201698785922554 0.816270816270816 0.727272727272727 30.2 30 2 abnormal hair medulla 0.0802335472041678 0.201698785922554 0.816270816270816 0.727272727272727 30.2 30 2 pharyngeal arch hypoplasia 0.0802335472041678 0.201698785922554 0.816270816270816 0.727272727272727 30.2 30 2 abnormal crista ampullaris neuroepithelium morphology 0.0802335472041678 0.201698785922554 0.816270816270816 0.727272727272727 30.2 30 2 cyclopia 0.0802335472041678 0.201698785922554 0.816270816270816 0.727272727272727 30.2 30 2 abnormal Bruch membrane morphology 0.0802335472041678 0.201698785922554 0.816270816270816 0.727272727272727 30.2 30 2 abnormal aorta smooth muscle morphology 0.0802335472041678 0.201698785922554 0.816270816270816 0.727272727272727 30.2 30 2 aberrant origin of the right subclavian artery 0.0802335472041678 0.201698785922554 0.816270816270816 0.727272727272727 30.2 30 2 abnormal extraembryonic ectoderm morphology 0.0802335472041678 0.201698785922554 0.816270816270816 0.727272727272727 30.2 30 2 increased subcutaneous adipose tissue amount 0.0802335472041678 0.201698785922554 0.816270816270816 0.727272727272727 30.2 30 2 decreased core body temperature 0.0802335472041678 0.201698785922554 0.816270816270816 0.727272727272727 30.2 30 2 decreased circulating HDL cholesterol level 3.74956512791042e-09 9.76653744049966e-08 0.815473676801802 0.7265625 30.2 30 2 decreased lymphocyte cell number 3.74956512791042e-09 9.76653744049966e-08 0.815473676801802 0.7265625 30.2 30 2 decreased hematocrit 3.35283061585254e-10 1.08313846193938e-08 0.814873092270353 0.726027397260274 30.2 30 2 distended abdomen 0.000202055890268947 0.00158303630565041 0.814270152505447 0.725490196078431 30.2 30 2 abnormal cued conditioning behavior 0.000202055890268947 0.00158303630565041 0.814270152505447 0.725490196078431 30.2 30 2 abnormal dendritic spine morphology 0.000202055890268947 0.00158303630565041 0.814270152505447 0.725490196078431 30.2 30 2 abnormal female reproductive system morphology 0.00100329869448455 0.00618104391533197 0.81371996996997 0.725 30.2 30 2 abnormal retinal pigmentation 1.45292918332371e-06 1.98580293599875e-05 0.812752407579994 0.724137931034483 30.2 30 2 increased circulating triglyceride level 5.20158878024443e-10 1.62754114350415e-08 0.812752407579994 0.724137931034483 30.2 30 2 abnormal spermiogenesis 8.14665508395569e-05 0.000708983647107486 0.812752407579994 0.724137931034483 30.2 30 2 abnormal enzyme/coenzyme level 8.14665508395569e-05 0.000708983647107486 0.812752407579994 0.724137931034483 30.2 30 2 decreased retinal photoreceptor cell number 0.00514720558613292 0.023578200409267 0.812752407579994 0.724137931034483 30.2 30 2 aphagia 0.00514720558613292 0.023578200409267 0.812752407579994 0.724137931034483 30.2 30 2 increased total body fat amount 2.41710461017155e-09 6.64369913569251e-08 0.812463582985971 0.723880597014925 30.2 30 2 abnormal T-helper 1 physiology 0.000399037270372235 0.00286053374654448 0.811928950226823 0.723404255319149 30.2 30 2 decreased bone trabecula number 0.000399037270372235 0.00286053374654448 0.811928950226823 0.723404255319149 30.2 30 2 abnormal inflammatory response 1.3448560143425e-05 0.000146403909657635 0.810602268935602 0.722222222222222 30.2 30 2 abnormal uterus morphology 0.00200121634062906 0.0110869168091643 0.810602268935602 0.722222222222222 30.2 30 2 underdeveloped hair follicles 0.0281076030267393 0.0896380288833512 0.810602268935602 0.722222222222222 30.2 30 2 delayed kidney development 0.0281076030267393 0.0896380288833512 0.810602268935602 0.722222222222222 30.2 30 2 abnormal mammary gland morphology 0.0281076030267393 0.0896380288833512 0.810602268935602 0.722222222222222 30.2 30 2 abnormal retinal rod cell morphology 0.0281076030267393 0.0896380288833512 0.810602268935602 0.722222222222222 30.2 30 2 abnormal phrenic nerve morphology 0.0281076030267393 0.0896380288833512 0.810602268935602 0.722222222222222 30.2 30 2 thick dermal layer 0.0281076030267393 0.0896380288833512 0.810602268935602 0.722222222222222 30.2 30 2 abnormal thymus medulla morphology 0.0281076030267393 0.0896380288833512 0.810602268935602 0.722222222222222 30.2 30 2 acidosis 0.0281076030267393 0.0896380288833512 0.810602268935602 0.722222222222222 30.2 30 2 absent allantois 0.0281076030267393 0.0896380288833512 0.810602268935602 0.722222222222222 30.2 30 2 abnormal redox activity 0.0281076030267393 0.0896380288833512 0.810602268935602 0.722222222222222 30.2 30 2 increased circulating renin level 0.0281076030267393 0.0896380288833512 0.810602268935602 0.722222222222222 30.2 30 2 increased circulating glycerol level 0.0281076030267393 0.0896380288833512 0.810602268935602 0.722222222222222 30.2 30 2 decreased activity of thyroid 0.0281076030267393 0.0896380288833512 0.810602268935602 0.722222222222222 30.2 30 2 abnormal neutrophil morphology 0.0281076030267393 0.0896380288833512 0.810602268935602 0.722222222222222 30.2 30 2 abnormal anterior eye segment morphology 0.0281076030267393 0.0896380288833512 0.810602268935602 0.722222222222222 30.2 30 2 abnormal pregnancy 0.0281076030267393 0.0896380288833512 0.810602268935602 0.722222222222222 30.2 30 2 abnormal macrophage chemotaxis 0.0281076030267393 0.0896380288833512 0.810602268935602 0.722222222222222 30.2 30 2 primary atelectasis 0.0281076030267393 0.0896380288833512 0.810602268935602 0.722222222222222 30.2 30 2 impaired leukocyte tethering or rolling 0.0281076030267393 0.0896380288833512 0.810602268935602 0.722222222222222 30.2 30 2 abnormal osteoblast physiology 0.00016008052623989 0.00128029021434025 0.810602268935602 0.722222222222222 30.2 30 2 increased double-negative T cell number 6.46427222943897e-05 0.000581550711418786 0.809580071875154 0.721311475409836 30.2 30 2 abnormal homeostasis 0.000789792166939535 0.00515645148362754 0.809152175431245 0.720930232558139 30.2 30 2 abnormal definitive hematopoiesis 9.25507362803394e-07 1.35822983184274e-05 0.808590848913429 0.720430107526882 30.2 30 2 spleen hyperplasia 1.06948236612282e-05 0.000118500551702918 0.808108108108108 0.72 30.2 30 2 increased monocyte cell number 3.81063960361216e-07 6.49244247533236e-06 0.808108108108108 0.72 30.2 30 2 decreased double-positive T cell number 3.81063960361216e-07 6.49244247533236e-06 0.808108108108108 0.72 30.2 30 2 decreased circulating alkaline phosphatase level 0.000315020671268044 0.0022879238533701 0.808108108108108 0.72 30.2 30 2 abnormal circulating protein level 0.000315020671268044 0.0022879238533701 0.808108108108108 0.72 30.2 30 2 mandible hypoplasia 0.0104491831655483 0.0430693340916343 0.808108108108108 0.72 30.2 30 2 abnormal energy expenditure 0.0104491831655483 0.0430693340916343 0.808108108108108 0.72 30.2 30 2 improved glucose tolerance 1.3937439823145e-12 6.24673541622941e-11 0.807420941349513 0.719387755102041 30.2 30 2 no abnormal phenotype detected 1.42401418617665e-102 3.54223528811441e-99 0.807331827504738 0.719308357348703 30.2 30 2 abnormal seminiferous tubule morphology 9.93621334758916e-10 2.9250095505477e-08 0.807185610267802 0.719178082191781 30.2 30 2 abnormal urine homeostasis 7.37487450008782e-07 1.11859758042491e-05 0.806705142642643 0.71875 30.2 30 2 increased circulating follicle stimulating hormone level 0.00400772203537554 0.0191900068585114 0.806705142642643 0.71875 30.2 30 2 abnormal lymphatic vessel morphology 0.00400772203537554 0.0191900068585114 0.806705142642643 0.71875 30.2 30 2 abnormal diaphragm morphology 0.00400772203537554 0.0191900068585114 0.806705142642643 0.71875 30.2 30 2 abnormal embryonic hematopoiesis 0.00400772203537554 0.0191900068585114 0.806705142642643 0.71875 30.2 30 2 abnormal spongiotrophoblast layer morphology 0.00400772203537554 0.0191900068585114 0.806705142642643 0.71875 30.2 30 2 bradykinesia 0.00400772203537554 0.0191900068585114 0.806705142642643 0.71875 30.2 30 2 abnormal auditory brainstem response waveform shape 0.00400772203537554 0.0191900068585114 0.806705142642643 0.71875 30.2 30 2 abnormal CD4-positive, alpha-beta T cell physiology 2.08207451488683e-05 0.000214457985746625 0.806211140718183 0.71830985915493 30.2 30 2 increased rib number 8.49547795798208e-06 9.64753850326911e-05 0.805805805805806 0.717948717948718 30.2 30 2 increased vascular permeability 0.00156717490954916 0.0091189417251545 0.805805805805806 0.717948717948718 30.2 30 2 decreased trabecular bone volume 0.00156717490954916 0.0091189417251545 0.805805805805806 0.717948717948718 30.2 30 2 thrombocytopenia 1.52728030913491e-09 4.34183973596924e-08 0.805011908460184 0.717241379310345 30.2 30 2 abnormal placenta development 0.00024839619017692 0.00191000161689363 0.804719814153776 0.716981132075472 30.2 30 2 abnormal femur morphology 4.05514946682717e-05 0.000387223965402403 0.804087669759312 0.716417910447761 30.2 30 2 abnormal skeleton development 6.74187434388811e-06 7.98591068115317e-05 0.803674044414785 0.716049382716049 30.2 30 2 hyperglycemia 2.76226899275285e-06 3.63271924438386e-05 0.803516584766585 0.715909090909091 30.2 30 2 hydronephrosis 5.34570243021795e-06 6.45506543454715e-05 0.801694551694552 0.714285714285714 30.2 30 2 dehydration 3.20714673431073e-05 0.000311238546072576 0.801694551694552 0.714285714285714 30.2 30 2 abnormal pancreas morphology 0.00122629144368731 0.00738595633455734 0.801694551694552 0.714285714285714 30.2 30 2 thick pulmonary interalveolar septum 0.00311894036544225 0.0160296780145405 0.801694551694552 0.714285714285714 30.2 30 2 abnormal midbrain development 0.00311894036544225 0.0160296780145405 0.801694551694552 0.714285714285714 30.2 30 2 abnormal scapula morphology 0.0213943215766882 0.0760805931694239 0.801694551694552 0.714285714285714 30.2 30 2 abnormal salivary gland morphology 0.0213943215766882 0.0760805931694239 0.801694551694552 0.714285714285714 30.2 30 2 decreased cochlear outer hair cell number 0.0213943215766882 0.0760805931694239 0.801694551694552 0.714285714285714 30.2 30 2 increased body weight 1.2086697679805e-13 6.19910525330206e-12 0.801694551694552 0.714285714285714 30.2 30 2 abnormal hair follicle morphology 7.90154456100743e-05 0.000690864397030087 0.801694551694552 0.714285714285714 30.2 30 2 abnormal circulating cholesterol level 0.00806507187298565 0.0344114344494885 0.801694551694552 0.714285714285714 30.2 30 2 straub tail 0.00806507187298565 0.0344114344494885 0.801694551694552 0.714285714285714 30.2 30 2 megacephaly 0.0593466656838167 0.156714257843412 0.801694551694552 0.714285714285714 30.2 30 2 increased aggression towards males 0.0593466656838167 0.156714257843412 0.801694551694552 0.714285714285714 30.2 30 2 abnormal pinna reflex 0.0593466656838167 0.156714257843412 0.801694551694552 0.714285714285714 30.2 30 2 abnormal placing response 0.0593466656838167 0.156714257843412 0.801694551694552 0.714285714285714 30.2 30 2 extended life span 0.0593466656838167 0.156714257843412 0.801694551694552 0.714285714285714 30.2 30 2 abnormal antigen presentation 0.0593466656838167 0.156714257843412 0.801694551694552 0.714285714285714 30.2 30 2 abnormal endplate potential 0.0593466656838167 0.156714257843412 0.801694551694552 0.714285714285714 30.2 30 2 absent otoliths 0.0593466656838167 0.156714257843412 0.801694551694552 0.714285714285714 30.2 30 2 abnormal kidney medulla morphology 0.0593466656838167 0.156714257843412 0.801694551694552 0.714285714285714 30.2 30 2 abnormal ventral body wall morphology 0.0593466656838167 0.156714257843412 0.801694551694552 0.714285714285714 30.2 30 2 premature hair loss 0.0593466656838167 0.156714257843412 0.801694551694552 0.714285714285714 30.2 30 2 abnormal glucose tolerance 0.0593466656838167 0.156714257843412 0.801694551694552 0.714285714285714 30.2 30 2 increased pulmonary respiratory rate 0.0593466656838167 0.156714257843412 0.801694551694552 0.714285714285714 30.2 30 2 decreased compact bone area 0.0593466656838167 0.156714257843412 0.801694551694552 0.714285714285714 30.2 30 2 cochlear degeneration 0.182010230582679 0.353849510413767 0.801694551694552 0.714285714285714 30.2 30 2 absent endolymphatic duct 0.182010230582679 0.353849510413767 0.801694551694552 0.714285714285714 30.2 30 2 growth retardation of molars 0.182010230582679 0.353849510413767 0.801694551694552 0.714285714285714 30.2 30 2 failure of atrioventricular cushion closure 0.182010230582679 0.353849510413767 0.801694551694552 0.714285714285714 30.2 30 2 retina hyperplasia 0.182010230582679 0.353849510413767 0.801694551694552 0.714285714285714 30.2 30 2 limp posture 0.182010230582679 0.353849510413767 0.801694551694552 0.714285714285714 30.2 30 2 abnormal vascular permeability 0.182010230582679 0.353849510413767 0.801694551694552 0.714285714285714 30.2 30 2 absent amniotic folds 0.182010230582679 0.353849510413767 0.801694551694552 0.714285714285714 30.2 30 2 abnormal brain ventricular system morphology 0.182010230582679 0.353849510413767 0.801694551694552 0.714285714285714 30.2 30 2 abnormal adrenal gland physiology 0.182010230582679 0.353849510413767 0.801694551694552 0.714285714285714 30.2 30 2 detached tectorial membrane 0.182010230582679 0.353849510413767 0.801694551694552 0.714285714285714 30.2 30 2 absent tunnel of Corti 0.182010230582679 0.353849510413767 0.801694551694552 0.714285714285714 30.2 30 2 abnormal thyroid gland development 0.182010230582679 0.353849510413767 0.801694551694552 0.714285714285714 30.2 30 2 abnormal prostate gland physiology 0.182010230582679 0.353849510413767 0.801694551694552 0.714285714285714 30.2 30 2 anuria 0.182010230582679 0.353849510413767 0.801694551694552 0.714285714285714 30.2 30 2 increased cell nucleus count 0.182010230582679 0.353849510413767 0.801694551694552 0.714285714285714 30.2 30 2 abnormal hard palate morphology 0.182010230582679 0.353849510413767 0.801694551694552 0.714285714285714 30.2 30 2 skeletal muscle interstitial fibrosis 0.182010230582679 0.353849510413767 0.801694551694552 0.714285714285714 30.2 30 2 abnormal central pattern generator function 0.182010230582679 0.353849510413767 0.801694551694552 0.714285714285714 30.2 30 2 abnormal Purkinje cell innervation 0.182010230582679 0.353849510413767 0.801694551694552 0.714285714285714 30.2 30 2 absent vestibular saccule 0.182010230582679 0.353849510413767 0.801694551694552 0.714285714285714 30.2 30 2 utricular macular degeneration 0.182010230582679 0.353849510413767 0.801694551694552 0.714285714285714 30.2 30 2 absent endocochlear potential 0.182010230582679 0.353849510413767 0.801694551694552 0.714285714285714 30.2 30 2 abnormal cochlear nerve compound action potential 0.182010230582679 0.353849510413767 0.801694551694552 0.714285714285714 30.2 30 2 abnormal MHC II cell surface expression on macrophages 0.182010230582679 0.353849510413767 0.801694551694552 0.714285714285714 30.2 30 2 decreased adrenocorticotropin level 0.182010230582679 0.353849510413767 0.801694551694552 0.714285714285714 30.2 30 2 increased thyroid-stimulating hormone level 0.182010230582679 0.353849510413767 0.801694551694552 0.714285714285714 30.2 30 2 absent thyroid gland 0.182010230582679 0.353849510413767 0.801694551694552 0.714285714285714 30.2 30 2 atherosclerotic lesions 0.182010230582679 0.353849510413767 0.801694551694552 0.714285714285714 30.2 30 2 abnormal thyroid hormone level 0.182010230582679 0.353849510413767 0.801694551694552 0.714285714285714 30.2 30 2 increased chronic myelocytic leukemia incidence 0.182010230582679 0.353849510413767 0.801694551694552 0.714285714285714 30.2 30 2 abnormal renal filtration rate 0.182010230582679 0.353849510413767 0.801694551694552 0.714285714285714 30.2 30 2 increased keratinocyte apoptosis 0.182010230582679 0.353849510413767 0.801694551694552 0.714285714285714 30.2 30 2 postaxial polydactyly 0.182010230582679 0.353849510413767 0.801694551694552 0.714285714285714 30.2 30 2 increased tumor latency 0.182010230582679 0.353849510413767 0.801694551694552 0.714285714285714 30.2 30 2 abnormal sperm annulus morphology 0.182010230582679 0.353849510413767 0.801694551694552 0.714285714285714 30.2 30 2 abnormal cerebellum white matter morphology 0.182010230582679 0.353849510413767 0.801694551694552 0.714285714285714 30.2 30 2 decreased DN4 thymocyte number 0.182010230582679 0.353849510413767 0.801694551694552 0.714285714285714 30.2 30 2 focal dorsal hair loss 0.182010230582679 0.353849510413767 0.801694551694552 0.714285714285714 30.2 30 2 decreased T-helper 17 cell number 0.182010230582679 0.353849510413767 0.801694551694552 0.714285714285714 30.2 30 2 abnormal conotruncal ridge morphology 0.182010230582679 0.353849510413767 0.801694551694552 0.714285714285714 30.2 30 2 small lung saccule 0.182010230582679 0.353849510413767 0.801694551694552 0.714285714285714 30.2 30 2 impaired branching involved in bronchus morphogenesis 0.182010230582679 0.353849510413767 0.801694551694552 0.714285714285714 30.2 30 2 parturition failure 0.182010230582679 0.353849510413767 0.801694551694552 0.714285714285714 30.2 30 2 impaired mammary gland growth during pregnancy 0.182010230582679 0.353849510413767 0.801694551694552 0.714285714285714 30.2 30 2 decreased volumetric bone mineral density 0.182010230582679 0.353849510413767 0.801694551694552 0.714285714285714 30.2 30 2 fragmented Meckel's cartilage 0.182010230582679 0.353849510413767 0.801694551694552 0.714285714285714 30.2 30 2 absent connection between subcutaneous lymph vessels and lymph sac 0.182010230582679 0.353849510413767 0.801694551694552 0.714285714285714 30.2 30 2 decreased collagen level 0.182010230582679 0.353849510413767 0.801694551694552 0.714285714285714 30.2 30 2 abnormal social investigation 1.03446741366321e-05 0.000115651132201674 0.799690315315315 0.7125 30.2 30 2 decreased percent body fat/body weight 2.53451544303273e-05 0.000253197074881282 0.799498128265252 0.712328767123288 30.2 30 2 impaired swimming 6.23350033469138e-05 0.000561805510237131 0.799265174265174 0.712121212121212 30.2 30 2 decreased IgG level 2.34070731414162e-07 4.15893531709092e-06 0.798805562319076 0.711711711711712 30.2 30 2 increased susceptibility to injury 0.000382887582562813 0.0027649266835346 0.798611111111111 0.711538461538462 30.2 30 2 altered response to myocardial infarction 0.000959060341475674 0.00603201668627242 0.798131464798131 0.711111111111111 30.2 30 2 increased bone marrow cell number 0.00242684822281093 0.0128991131500901 0.797475106685633 0.710526315789474 30.2 30 2 male infertility 8.53823861773281e-28 2.35987428462337e-25 0.79659430802572 0.709741550695825 30.2 30 2 absent mature ovarian follicles 0.00622875045642946 0.0279171473159789 0.796522328780393 0.709677419354839 30.2 30 2 increased lung adenoma incidence 0.00622875045642946 0.0279171473159789 0.796522328780393 0.709677419354839 30.2 30 2 abnormal capillary morphology 0.00622875045642946 0.0279171473159789 0.796522328780393 0.709677419354839 30.2 30 2 decreased T cell proliferation 3.44560827320719e-09 9.1667920637464e-08 0.796277696615534 0.709459459459459 30.2 30 2 increased sensitivity to xenobiotic induced morbidity/mortality 3.56471866261455e-07 6.20086550577181e-06 0.795864045864046 0.709090909090909 30.2 30 2 abnormal learning/memory/conditioning 0.00030040973565374 0.00219140532973219 0.795864045864046 0.709090909090909 30.2 30 2 hunched posture 1.57990547106063e-05 0.000166526053358615 0.795605732314593 0.708860759493671 30.2 30 2 abnormal response to infection 1.57990547106063e-05 0.000166526053358615 0.795605732314593 0.708860759493671 30.2 30 2 decreased B cell number 3.73409949903148e-12 1.52271680390833e-10 0.795467797894982 0.70873786407767 30.2 30 2 curly tail 0.000749825957393738 0.00492135110558555 0.795013763763764 0.708333333333333 30.2 30 2 decreased metastatic potential 0.0163271874207628 0.0608903728772824 0.795013763763764 0.708333333333333 30.2 30 2 curly vibrissae 0.0163271874207628 0.0608903728772824 0.795013763763764 0.708333333333333 30.2 30 2 apnea 0.0163271874207628 0.0608903728772824 0.795013763763764 0.708333333333333 30.2 30 2 small lymph nodes 0.0163271874207628 0.0608903728772824 0.795013763763764 0.708333333333333 30.2 30 2 decreased ovulation rate 0.0163271874207628 0.0608903728772824 0.795013763763764 0.708333333333333 30.2 30 2 abnormal cholesterol homeostasis 0.00188839774689582 0.0104852441861682 0.793873141434117 0.707317073170732 30.2 30 2 abnormal oocyte morphology 0.00481418515048045 0.0225523268584183 0.792262851086381 0.705882352941177 30.2 30 2 hydroureter 0.0443027837509103 0.132400027635395 0.792262851086381 0.705882352941177 30.2 30 2 abnormal vagus nerve morphology 0.0443027837509103 0.132400027635395 0.792262851086381 0.705882352941177 30.2 30 2 increased incidence of corneal inflammation 0.0443027837509103 0.132400027635395 0.792262851086381 0.705882352941177 30.2 30 2 abnormal heart rate 0.0443027837509103 0.132400027635395 0.792262851086381 0.705882352941177 30.2 30 2 abnormal touch/ nociception 0.0443027837509103 0.132400027635395 0.792262851086381 0.705882352941177 30.2 30 2 decreased vasoconstriction 0.0443027837509103 0.132400027635395 0.792262851086381 0.705882352941177 30.2 30 2 abnormal involuntary movement 0.0443027837509103 0.132400027635395 0.792262851086381 0.705882352941177 30.2 30 2 abnormal testis development 0.0443027837509103 0.132400027635395 0.792262851086381 0.705882352941177 30.2 30 2 increased trabecular bone mass 0.0443027837509103 0.132400027635395 0.792262851086381 0.705882352941177 30.2 30 2 abnormal electroretinogram waveform feature 0.0443027837509103 0.132400027635395 0.792262851086381 0.705882352941177 30.2 30 2 delayed heart development 0.0443027837509103 0.132400027635395 0.792262851086381 0.705882352941177 30.2 30 2 impaired hematopoiesis 0.000586136145665875 0.00390888381325433 0.79226285108638 0.705882352941177 30.2 30 2 increased lung adenocarcinoma incidence 0.000586136145665875 0.00390888381325433 0.79226285108638 0.705882352941177 30.2 30 2 cochlear inner hair cell degeneration 0.000586136145665875 0.00390888381325433 0.79226285108638 0.705882352941177 30.2 30 2 impaired righting response 3.18432602580349e-06 4.14712617234878e-05 0.791567883673147 0.705263157894737 30.2 30 2 abnormal excitatory postsynaptic currents 2.40141457192552e-05 0.000242825965352225 0.791416416416416 0.705128205128205 30.2 30 2 abnormal suckling behavior 7.74859752792262e-06 8.94414679847216e-05 0.790762353262353 0.704545454545455 30.2 30 2 decreased macrophage cell number 0.00146965609528845 0.00863227753726097 0.790762353262353 0.704545454545455 30.2 30 2 abnormal amino acid level 0.00146965609528845 0.00863227753726097 0.790762353262353 0.704545454545455 30.2 30 2 abnormal heart valve morphology 0.0124901085898736 0.0483628557770328 0.789817595373151 0.703703703703704 30.2 30 2 increased exploration in new environment 1.89013236443991e-05 0.000196313330127109 0.789817595373151 0.703703703703704 30.2 30 2 increased white adipose tissue amount 0.00372389446115382 0.0182166911939432 0.78869409950491 0.702702702702703 30.2 30 2 increased insulin secretion 0.00372389446115382 0.0182166911939432 0.78869409950491 0.702702702702703 30.2 30 2 abnormal nervous system electrophysiology 1.48731990949009e-05 0.000159127237628241 0.788332975832976 0.702380952380952 30.2 30 2 increased food intake 1.48731990949009e-05 0.000159127237628241 0.788332975832976 0.702380952380952 30.2 30 2 decreased T cell number 2.45706289887181e-09 6.71642193510288e-08 0.787752037752038 0.701863354037267 30.2 30 2 abnormal blood homeostasis 5.09675422612245e-07 8.29478465923329e-06 0.787629734998156 0.701754385964912 30.2 30 2 maternal effect 0.000113526248741724 0.000952433537082763 0.787335843305993 0.701492537313433 30.2 30 2 decreased IgM level 3.78949837024141e-06 4.77284921315216e-05 0.786817745580632 0.701030927835051 30.2 30 2 increased B cell number 4.02155754195569e-07 6.7364473977204e-06 0.78661995328662 0.700854700854701 30.2 30 2 delayed eyelid opening 0.00957540281186666 0.0400316209991905 0.785660660660661 0.7 30.2 30 2 abnormal spleen marginal zone morphology 0.00957540281186666 0.0400316209991905 0.785660660660661 0.7 30.2 30 2 small gonad 0.0333011636376732 0.10426261113746 0.785660660660661 0.7 30.2 30 2 decreased paired-pulse facilitation 0.0333011636376732 0.10426261113746 0.785660660660661 0.7 30.2 30 2 abnormal male reproductive system physiology 0.0333011636376732 0.10426261113746 0.785660660660661 0.7 30.2 30 2 decreased circulating VLDL cholesterol level 0.0333011636376732 0.10426261113746 0.785660660660661 0.7 30.2 30 2 increased cranium width 0.128615117618988 0.270668447611871 0.785660660660661 0.7 30.2 30 2 kidney hemorrhage 0.128615117618988 0.270668447611871 0.785660660660661 0.7 30.2 30 2 abnormal grooming behavior 0.128615117618988 0.270668447611871 0.785660660660661 0.7 30.2 30 2 rhinitis 0.128615117618988 0.270668447611871 0.785660660660661 0.7 30.2 30 2 abnormal mammary gland physiology 0.128615117618988 0.270668447611871 0.785660660660661 0.7 30.2 30 2 alcohol preference 0.128615117618988 0.270668447611871 0.785660660660661 0.7 30.2 30 2 decreased incidence of induced tumors 0.128615117618988 0.270668447611871 0.785660660660661 0.7 30.2 30 2 abnormal airway responsiveness 0.128615117618988 0.270668447611871 0.785660660660661 0.7 30.2 30 2 decreased circulating parathyroid hormone level 0.128615117618988 0.270668447611871 0.785660660660661 0.7 30.2 30 2 impaired social transmission of food preference 0.128615117618988 0.270668447611871 0.785660660660661 0.7 30.2 30 2 primary sex reversal 0.128615117618988 0.270668447611871 0.785660660660661 0.7 30.2 30 2 delayed dark adaptation 0.128615117618988 0.270668447611871 0.785660660660661 0.7 30.2 30 2 abnormal tibialis anterior morphology 0.128615117618988 0.270668447611871 0.785660660660661 0.7 30.2 30 2 abnormal hypaxial muscle morphology 0.128615117618988 0.270668447611871 0.785660660660661 0.7 30.2 30 2 lymphedema 0.128615117618988 0.270668447611871 0.785660660660661 0.7 30.2 30 2 cochlear ganglion hypoplasia 0.128615117618988 0.270668447611871 0.785660660660661 0.7 30.2 30 2 increased atrioventricular cushion size 0.128615117618988 0.270668447611871 0.785660660660661 0.7 30.2 30 2 abnormal pillar cell morphology 0.128615117618988 0.270668447611871 0.785660660660661 0.7 30.2 30 2 absent pharyngeal arches 0.128615117618988 0.270668447611871 0.785660660660661 0.7 30.2 30 2 decreased cochlear inner hair cell number 0.128615117618988 0.270668447611871 0.785660660660661 0.7 30.2 30 2 absent coat pigmentation 0.128615117618988 0.270668447611871 0.785660660660661 0.7 30.2 30 2 ascites 0.128615117618988 0.270668447611871 0.785660660660661 0.7 30.2 30 2 tachypnea 0.128615117618988 0.270668447611871 0.785660660660661 0.7 30.2 30 2 abnormal developmental vascular remodeling 0.128615117618988 0.270668447611871 0.785660660660661 0.7 30.2 30 2 absent inguinal lymph nodes 0.128615117618988 0.270668447611871 0.785660660660661 0.7 30.2 30 2 absent axillary lymph nodes 0.128615117618988 0.270668447611871 0.785660660660661 0.7 30.2 30 2 abnormal cerebellar granule cell migration 0.128615117618988 0.270668447611871 0.785660660660661 0.7 30.2 30 2 increased T-helper 17 cell number 0.128615117618988 0.270668447611871 0.785660660660661 0.7 30.2 30 2 thick aortic valve cusps 0.128615117618988 0.270668447611871 0.785660660660661 0.7 30.2 30 2 thick aortic valve 0.128615117618988 0.270668447611871 0.785660660660661 0.7 30.2 30 2 sinus bradycardia 0.128615117618988 0.270668447611871 0.785660660660661 0.7 30.2 30 2 thin ventricular wall 9.20363837740339e-06 0.000103592988523941 0.785660660660661 0.7 30.2 30 2 thick epidermis 8.89815259388544e-05 0.000761933031920483 0.785660660660661 0.7 30.2 30 2 increased body length 0.000890841448730711 0.00570390760287682 0.785660660660661 0.7 30.2 30 2 increased bone mineral density 7.65625197838627e-07 1.14728474676119e-05 0.784667410773605 0.699115044247788 30.2 30 2 increased spleen weight 7.65625197838627e-07 1.14728474676119e-05 0.784667410773605 0.699115044247788 30.2 30 2 lung inflammation 6.46818319954805e-08 1.31882014007178e-06 0.784010113054231 0.698529411764706 30.2 30 2 abnormal male reproductive system morphology 0.00223359746695142 0.012251540681459 0.783050492352818 0.697674418604651 30.2 30 2 abnormal axon guidance 0.00223359746695142 0.012251540681459 0.783050492352818 0.697674418604651 30.2 30 2 absent vibrissae 0.00735501868656048 0.0314898605556269 0.782259532259532 0.696969696969697 30.2 30 2 abnormal T cell subpopulation ratio 0.00735501868656048 0.0314898605556269 0.782259532259532 0.696969696969697 30.2 30 2 cardiovascular system phenotype 0.00735501868656048 0.0314898605556269 0.782259532259532 0.696969696969697 30.2 30 2 abnormal innervation pattern to muscle 0.0251664645486648 0.081406476677248 0.780780780780781 0.695652173913043 30.2 30 2 blistering 0.0251664645486648 0.081406476677248 0.780780780780781 0.695652173913043 30.2 30 2 failure of embryo implantation 0.0251664645486648 0.081406476677248 0.780780780780781 0.695652173913043 30.2 30 2 abnormal crista ampullaris morphology 0.0251664645486648 0.081406476677248 0.780780780780781 0.695652173913043 30.2 30 2 abnormal chondrocyte physiology 0.0251664645486648 0.081406476677248 0.780780780780781 0.695652173913043 30.2 30 2 abnormal basicranium morphology 0.0251664645486648 0.081406476677248 0.780780780780781 0.695652173913043 30.2 30 2 decreased effector memory CD8-positive, alpha-beta T cell number 0.0251664645486648 0.081406476677248 0.780780780780781 0.695652173913043 30.2 30 2 abnormal coat appearance 0.000133775698754119 0.001098241091257 0.780780780780781 0.695652173913043 30.2 30 2 sparse hair 3.35777714050269e-05 0.000324367791728173 0.780185673478357 0.695121951219512 30.2 30 2 abnormal excitatory postsynaptic potential 3.35777714050269e-05 0.000324367791728173 0.780185673478357 0.695121951219512 30.2 30 2 increased circulating glucose level 6.00287901887305e-08 1.23406293879725e-06 0.780088599237535 0.695035460992908 30.2 30 2 increased inflammatory response 8.51310432750782e-06 9.64753850326911e-05 0.779753437648175 0.694736842105263 30.2 30 2 abnormal epidermis stratum granulosum morphology 0.00565922224001765 0.0254860493875445 0.779425258591925 0.694444444444444 30.2 30 2 head tilt 0.00565922224001765 0.0254860493875445 0.779425258591925 0.694444444444444 30.2 30 2 abnormal respiratory system physiology 0.00134382647727071 0.00801623108443857 0.778788993074707 0.693877551020408 30.2 30 2 decreased circulating creatinine level 0.00134382647727071 0.00801623108443857 0.778788993074707 0.693877551020408 30.2 30 2 increased fluid intake 0.00134382647727071 0.00801623108443857 0.778788993074707 0.693877551020408 30.2 30 2 absent corpus luteum 0.00104344541264776 0.00639303069941206 0.777027027027027 0.692307692307692 30.2 30 2 increased autoantibody level 0.00436111317764991 0.02076223737685 0.777027027027027 0.692307692307692 30.2 30 2 impaired macrophage chemotaxis 0.00436111317764991 0.02076223737685 0.777027027027027 0.692307692307692 30.2 30 2 thick skin 0.0191011800849827 0.06921221480174 0.777027027027027 0.692307692307692 30.2 30 2 heart inflammation 0.0191011800849827 0.06921221480174 0.777027027027027 0.692307692307692 30.2 30 2 abnormal tectorial membrane morphology 0.0191011800849827 0.06921221480174 0.777027027027027 0.692307692307692 30.2 30 2 pulmonary edema 0.0191011800849827 0.06921221480174 0.777027027027027 0.692307692307692 30.2 30 2 decreased bone resorption 0.0191011800849827 0.06921221480174 0.777027027027027 0.692307692307692 30.2 30 2 decreased Peyer's patch number 0.0191011800849827 0.06921221480174 0.777027027027027 0.692307692307692 30.2 30 2 increased foot pad pigmentation 0.0931869052392669 0.222886948829497 0.777027027027027 0.692307692307692 30.2 30 2 uterus hypoplasia 0.0931869052392669 0.222886948829497 0.777027027027027 0.692307692307692 30.2 30 2 lymphoid hypoplasia 0.0931869052392669 0.222886948829497 0.777027027027027 0.692307692307692 30.2 30 2 abnormal bile duct development 0.0931869052392669 0.222886948829497 0.777027027027027 0.692307692307692 30.2 30 2 abnormal soleus morphology 0.0931869052392669 0.222886948829497 0.777027027027027 0.692307692307692 30.2 30 2 abnormal vestibulocochlear ganglion morphology 0.0931869052392669 0.222886948829497 0.777027027027027 0.692307692307692 30.2 30 2 decreased endocochlear potential 0.0931869052392669 0.222886948829497 0.777027027027027 0.692307692307692 30.2 30 2 hyperalgesia 0.0931869052392669 0.222886948829497 0.777027027027027 0.692307692307692 30.2 30 2 increased circulating thyroxine level 0.0931869052392669 0.222886948829497 0.777027027027027 0.692307692307692 30.2 30 2 orthokeratosis 0.0931869052392669 0.222886948829497 0.777027027027027 0.692307692307692 30.2 30 2 increased T cell proliferation 3.23428799322879e-06 4.2011965447293e-05 0.776220145379024 0.691588785046729 30.2 30 2 decreased anxiety-related response 6.52228544859812e-07 1.02038899706842e-05 0.775623184159769 0.691056910569106 30.2 30 2 increased circulating calcium level 0.000810732594509601 0.00525866317820764 0.775457275457275 0.690909090909091 30.2 30 2 increased anxiety-related response 1.32326912081667e-07 2.53852403583901e-06 0.775163652861495 0.690647482014389 30.2 30 2 skin edema 0.00336540411559168 0.0168556843461976 0.7749713999714 0.69047619047619 30.2 30 2 abnormal vibrissa morphology 0.00336540411559168 0.0168556843461976 0.7749713999714 0.69047619047619 30.2 30 2 abnormal ovary morphology 0.000156072826629632 0.00125641150887123 0.774595017552764 0.690140845070423 30.2 30 2 thrombocytosis 0.000630303501429557 0.0041810132261494 0.774049911980946 0.689655172413793 30.2 30 2 abnormal microglial cell morphology 0.0145492191771029 0.054545866922447 0.774049911980946 0.689655172413793 30.2 30 2 polychromatophilia 0.0145492191771029 0.054545866922447 0.774049911980946 0.689655172413793 30.2 30 2 decreased osteoclast cell number 0.00260026097873102 0.0136028374018789 0.77318985652319 0.688888888888889 30.2 30 2 lethality at weaning, complete penetrance 0.00260026097873102 0.0136028374018789 0.77318985652319 0.688888888888889 30.2 30 2 abnormal kidney physiology 0.00201133693547361 0.0111182236155347 0.771631006006006 0.6875 30.2 30 2 abnormal hair shaft morphology 0.00201133693547361 0.0111182236155347 0.771631006006006 0.6875 30.2 30 2 polydipsia 0.0111150129827481 0.044026424832143 0.771631006006006 0.6875 30.2 30 2 failure of primitive streak formation 0.0111150129827481 0.044026424832143 0.771631006006006 0.6875 30.2 30 2 abnormal lumbar vertebrae morphology 0.0111150129827481 0.044026424832143 0.771631006006006 0.6875 30.2 30 2 abnormal tympanic ring morphology 0.0685700579885895 0.175391279430968 0.771631006006006 0.6875 30.2 30 2 absent mandible 0.0685700579885895 0.175391279430968 0.771631006006006 0.6875 30.2 30 2 decreased mast cell number 0.0685700579885895 0.175391279430968 0.771631006006006 0.6875 30.2 30 2 disorganized retinal layers 0.0685700579885895 0.175391279430968 0.771631006006006 0.6875 30.2 30 2 abnormal olfaction 0.0685700579885895 0.175391279430968 0.771631006006006 0.6875 30.2 30 2 abnormal epicardium morphology 0.0685700579885895 0.175391279430968 0.771631006006006 0.6875 30.2 30 2 decreased cochlear coiling 0.0685700579885895 0.175391279430968 0.771631006006006 0.6875 30.2 30 2 abnormal molar crown morphology 0.0685700579885895 0.175391279430968 0.771631006006006 0.6875 30.2 30 2 bowed radius 0.0685700579885895 0.175391279430968 0.771631006006006 0.6875 30.2 30 2 abnormal amnion morphology 0.0685700579885895 0.175391279430968 0.771631006006006 0.6875 30.2 30 2 abnormal level of surface class II molecules 0.0685700579885895 0.175391279430968 0.771631006006006 0.6875 30.2 30 2 decreased circulating triiodothyronine level 0.0685700579885895 0.175391279430968 0.771631006006006 0.6875 30.2 30 2 decreased skeletal muscle weight 0.0685700579885895 0.175391279430968 0.771631006006006 0.6875 30.2 30 2 embryonic lethality between somite formation and embryo turning, incomplete penetrance 0.0685700579885895 0.175391279430968 0.771631006006006 0.6875 30.2 30 2 abnormal CNS synaptic transmission 1.15278359533235e-05 0.000126882707672089 0.770922437589104 0.686868686868687 30.2 30 2 increased circulating HDL cholesterol level 7.07303166760253e-06 8.26017195923065e-05 0.76962676962677 0.685714285714286 30.2 30 2 impaired fertilization 0.000231508439441966 0.00179554836221121 0.76962676962677 0.685714285714286 30.2 30 2 increased carcinoma incidence 0.00851290104510931 0.0356495645618004 0.76962676962677 0.685714285714286 30.2 30 2 abnormal intestinal goblet cell morphology 0.00851290104510931 0.0356495645618004 0.76962676962677 0.685714285714286 30.2 30 2 polyphagia 0.00120700847515103 0.00727862686530472 0.7690329218107 0.685185185185185 30.2 30 2 abnormal circulating amino acid level 0.000936253938008754 0.00593358387464147 0.767938991623202 0.684210526315789 30.2 30 2 abnormal retinal outer nuclear layer morphology 0.00653416131089673 0.0283469885476634 0.767938991623202 0.684210526315789 30.2 30 2 decreased threshold for auditory brainstem response 0.00653416131089673 0.0283469885476634 0.767938991623202 0.684210526315789 30.2 30 2 irregular coat pigmentation 0.0509946519142335 0.136690944651569 0.767938991623202 0.684210526315789 30.2 30 2 enlarged adrenal glands 0.0509946519142335 0.136690944651569 0.767938991623202 0.684210526315789 30.2 30 2 decreased grooming behavior 0.0509946519142335 0.136690944651569 0.767938991623202 0.684210526315789 30.2 30 2 decreased germ cell number 0.0509946519142335 0.136690944651569 0.767938991623202 0.684210526315789 30.2 30 2 abnormal neural crest cell migration 0.0509946519142335 0.136690944651569 0.767938991623202 0.684210526315789 30.2 30 2 Leydig cell hyperplasia 0.00502486094509853 0.0234729419735823 0.766498205522596 0.682926829268293 30.2 30 2 short humerus 0.00502486094509853 0.0234729419735823 0.766498205522596 0.682926829268293 30.2 30 2 abnormal dendritic cell physiology 8.13786768311119e-06 9.2645061152124e-05 0.765730683954983 0.682242990654206 30.2 30 2 increased T cell number 5.21996591942041e-05 0.000478256546024246 0.76525389025389 0.681818181818182 30.2 30 2 decreased sensitivity to induced morbidity/mortality 0.00387061469194348 0.0189158232734959 0.76525389025389 0.681818181818182 30.2 30 2 aphakia 0.038220466848251 0.115450408360685 0.76525389025389 0.681818181818182 30.2 30 2 parakeratosis 0.038220466848251 0.115450408360685 0.76525389025389 0.681818181818182 30.2 30 2 abnormal channel response 0.038220466848251 0.115450408360685 0.76525389025389 0.681818181818182 30.2 30 2 abnormal retinal layer morphology 0.038220466848251 0.115450408360685 0.76525389025389 0.681818181818182 30.2 30 2 abnormal retinal outer plexiform layer morphology 0.038220466848251 0.115450408360685 0.76525389025389 0.681818181818182 30.2 30 2 abnormal limb posture 0.038220466848251 0.115450408360685 0.76525389025389 0.681818181818182 30.2 30 2 decreased circulating estradiol level 0.038220466848251 0.115450408360685 0.76525389025389 0.681818181818182 30.2 30 2 abnormal mesenteric lymph node morphology 0.038220466848251 0.115450408360685 0.76525389025389 0.681818181818182 30.2 30 2 pulmonary vascular congestion 0.038220466848251 0.115450408360685 0.76525389025389 0.681818181818182 30.2 30 2 increased thermal nociceptive threshold 4.07726940587063e-05 0.000388590331306636 0.764693264693265 0.681318681318681 30.2 30 2 abnormal trabecular bone morphology 3.0600487950513e-06 4.00624809352111e-05 0.763967749261867 0.680672268907563 30.2 30 2 weight loss 1.82079047159716e-08 4.2029436689802e-07 0.763213213213213 0.68 30.2 30 2 testicular atrophy 0.00230641966291817 0.0126092723329867 0.763213213213213 0.68 30.2 30 2 decreased oocyte number 0.00230641966291817 0.0126092723329867 0.763213213213213 0.68 30.2 30 2 abnormal inner ear vestibule morphology 0.0288179464630937 0.0917269889020416 0.763213213213213 0.68 30.2 30 2 decreased placenta weight 0.0288179464630937 0.0917269889020416 0.763213213213213 0.68 30.2 30 2 decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 0.0288179464630937 0.0917269889020416 0.763213213213213 0.68 30.2 30 2 increased B cell proliferation 0.00107003349495327 0.0065478679426722 0.760930421947371 0.677966101694915 30.2 30 2 abnormal eye electrophysiology 3.49399421670267e-06 4.50326974821134e-05 0.760615987888715 0.677685950413223 30.2 30 2 abnormal cranial ganglia morphology 0.0166033727582848 0.0618276792458585 0.760316768381284 0.67741935483871 30.2 30 2 abnormal retinal photoreceptor layer morphology 0.0166033727582848 0.0618276792458585 0.760316768381284 0.67741935483871 30.2 30 2 thin skin 0.0126676706256369 0.0483628557770328 0.759251898957781 0.676470588235294 30.2 30 2 abnormal skin physiology 0.0126676706256369 0.0483628557770328 0.759251898957781 0.676470588235294 30.2 30 2 increased susceptibility to viral infection induced morbidity/mortality 0.0126676706256369 0.0483628557770328 0.759251898957781 0.676470588235294 30.2 30 2 increased leukocyte cell number 4.95804160946646e-07 8.12598844393336e-06 0.758568913741328 0.675862068965517 30.2 30 2 small seminiferous tubules 0.000302507385291284 0.00220347619593578 0.758359711062414 0.675675675675676 30.2 30 2 increased trabecular bone volume 0.00969115511265066 0.0404815253446155 0.758359711062414 0.675675675675676 30.2 30 2 decreased neutrophil cell number 6.48453714161295e-06 7.69942059177194e-05 0.757841174507841 0.675213675213675 30.2 30 2 decreased circulating phosphate level 0.00743127715377678 0.031788997282923 0.757601351351351 0.675 30.2 30 2 abnormal immune system morphology 0.00439493229198628 0.0208832742623035 0.756381381381381 0.673913043478261 30.2 30 2 abnormal sleep pattern 0.00439493229198628 0.0208832742623035 0.756381381381381 0.673913043478261 30.2 30 2 increased sarcoma incidence 0.0033880772555171 0.0168556843461976 0.755883434454863 0.673469387755102 30.2 30 2 abnormal female meiosis 0.00261549377146771 0.0136538106118068 0.755442942942943 0.673076923076923 30.2 30 2 increased percent body fat/body weight 0.00261549377146771 0.0136538106118068 0.755442942942943 0.673076923076923 30.2 30 2 abnormal T-helper 2 physiology 0.00202157556313621 0.0111624177875723 0.755050505050505 0.672727272727273 30.2 30 2 increased sacral vertebrae number 0.000939315879814243 0.00594541539704308 0.754093937687688 0.671875 30.2 30 2 increased liver weight 0.00012566497373669 0.00103678813323388 0.752499658749659 0.670454545454545 30.2 30 2 short femur 0.00012566497373669 0.00103678813323388 0.752499658749659 0.670454545454545 30.2 30 2 blepharoptosis 0.0766931451992525 0.195065642825297 0.748248248248248 0.666666666666667 30.2 30 2 decreased heart rate variability 0.0766931451992525 0.195065642825297 0.748248248248248 0.666666666666667 30.2 30 2 decreased lactate dehydrogenase level 0.0766931451992525 0.195065642825297 0.748248248248248 0.666666666666667 30.2 30 2 decreased fluid intake 0.0766931451992525 0.195065642825297 0.748248248248248 0.666666666666667 30.2 30 2 abnormal vagina epithelium morphology 0.200499508990482 0.378796256848557 0.748248248248248 0.666666666666667 30.2 30 2 psoriasis 0.200499508990482 0.378796256848557 0.748248248248248 0.666666666666667 30.2 30 2 abnormal lens vesicle development 0.200499508990482 0.378796256848557 0.748248248248248 0.666666666666667 30.2 30 2 abnormal kindling response 0.200499508990482 0.378796256848557 0.748248248248248 0.666666666666667 30.2 30 2 abnormal laryngeal cartilage morphology 0.200499508990482 0.378796256848557 0.748248248248248 0.666666666666667 30.2 30 2 long gestation period 0.200499508990482 0.378796256848557 0.748248248248248 0.666666666666667 30.2 30 2 abnormal gut-associated lymphoid tissue morphology 0.200499508990482 0.378796256848557 0.748248248248248 0.666666666666667 30.2 30 2 enlarged otoliths 0.200499508990482 0.378796256848557 0.748248248248248 0.666666666666667 30.2 30 2 absent posterior semicircular canal 0.200499508990482 0.378796256848557 0.748248248248248 0.666666666666667 30.2 30 2 abnormal lens capsule morphology 0.200499508990482 0.378796256848557 0.748248248248248 0.666666666666667 30.2 30 2 decreased fear-related response 0.200499508990482 0.378796256848557 0.748248248248248 0.666666666666667 30.2 30 2 decreased muscle weight 0.200499508990482 0.378796256848557 0.748248248248248 0.666666666666667 30.2 30 2 abnormal proprioceptive neuron morphology 0.200499508990482 0.378796256848557 0.748248248248248 0.666666666666667 30.2 30 2 small scapula 0.200499508990482 0.378796256848557 0.748248248248248 0.666666666666667 30.2 30 2 abnormal hair cell mechanoelectric transduction 0.200499508990482 0.378796256848557 0.748248248248248 0.666666666666667 30.2 30 2 decreased thyroid-stimulating hormone level 0.200499508990482 0.378796256848557 0.748248248248248 0.666666666666667 30.2 30 2 abnormal intervertebral disk development 0.200499508990482 0.378796256848557 0.748248248248248 0.666666666666667 30.2 30 2 decreased pulmonary ventilation 0.200499508990482 0.378796256848557 0.748248248248248 0.666666666666667 30.2 30 2 absent cervical lymph nodes 0.200499508990482 0.378796256848557 0.748248248248248 0.666666666666667 30.2 30 2 abnormal hippocampus granule cell morphology 0.200499508990482 0.378796256848557 0.748248248248248 0.666666666666667 30.2 30 2 abnormal incisor color 0.200499508990482 0.378796256848557 0.748248248248248 0.666666666666667 30.2 30 2 abnormal ventricle myocardium morphology 0.200499508990482 0.378796256848557 0.748248248248248 0.666666666666667 30.2 30 2 shortened ST segment 0.200499508990482 0.378796256848557 0.748248248248248 0.666666666666667 30.2 30 2 abnormal heart left ventricle pressure 0.200499508990482 0.378796256848557 0.748248248248248 0.666666666666667 30.2 30 2 decreased pancreatic beta cell proliferation 0.200499508990482 0.378796256848557 0.748248248248248 0.666666666666667 30.2 30 2 decreased bone trabecular spacing 0.200499508990482 0.378796256848557 0.748248248248248 0.666666666666667 30.2 30 2 abnormal cardiovascular system morphology 0.00493501140148371 0.0230965961640465 0.748248248248248 0.666666666666667 30.2 30 2 abnormal cartilage development 0.00641132211836841 0.0283469885476634 0.748248248248248 0.666666666666667 30.2 30 2 abnormal metabolism 0.00641132211836841 0.0283469885476634 0.748248248248248 0.666666666666667 30.2 30 2 abnormal pain threshold 0.0244968519075755 0.0796027682822913 0.748248248248248 0.666666666666667 30.2 30 2 abnormal skin appearance 0.0323233230752009 0.101456487254968 0.748248248248248 0.666666666666667 30.2 30 2 decreased bone ossification 0.0323233230752009 0.101456487254968 0.748248248248248 0.666666666666667 30.2 30 2 abnormal retinal ganglion layer morphology 0.0428450188044688 0.129027826000141 0.748248248248248 0.666666666666667 30.2 30 2 increased circulating total protein level 0.0428450188044688 0.129027826000141 0.748248248248248 0.666666666666667 30.2 30 2 decreased hepatocyte number 0.10398464608238 0.230543916094347 0.748248248248248 0.666666666666667 30.2 30 2 abnormal apical ectodermal ridge morphology 0.10398464608238 0.230543916094347 0.748248248248248 0.666666666666667 30.2 30 2 abnormal bronchus morphology 0.10398464608238 0.230543916094347 0.748248248248248 0.666666666666667 30.2 30 2 abnormal secondary palate development 0.10398464608238 0.230543916094347 0.748248248248248 0.666666666666667 30.2 30 2 liver vascular congestion 0.10398464608238 0.230543916094347 0.748248248248248 0.666666666666667 30.2 30 2 abnormal coronary vessel morphology 0.10398464608238 0.230543916094347 0.748248248248248 0.666666666666667 30.2 30 2 abnormal microglial cell activation 0.10398464608238 0.230543916094347 0.748248248248248 0.666666666666667 30.2 30 2 decreased trabecular bone mass 0.10398464608238 0.230543916094347 0.748248248248248 0.666666666666667 30.2 30 2 abnormal adipose tissue distribution 0.142915379065794 0.297989945872727 0.748248248248248 0.666666666666667 30.2 30 2 abnormal rectum morphology 0.142915379065794 0.297989945872727 0.748248248248248 0.666666666666667 30.2 30 2 abnormal superior cervical ganglion morphology 0.142915379065794 0.297989945872727 0.748248248248248 0.666666666666667 30.2 30 2 abnormal mating frequency 0.142915379065794 0.297989945872727 0.748248248248248 0.666666666666667 30.2 30 2 impaired embryo implantation 0.142915379065794 0.297989945872727 0.748248248248248 0.666666666666667 30.2 30 2 ear inflammation 0.142915379065794 0.297989945872727 0.748248248248248 0.666666666666667 30.2 30 2 myocarditis 0.142915379065794 0.297989945872727 0.748248248248248 0.666666666666667 30.2 30 2 increased papilloma incidence 0.142915379065794 0.297989945872727 0.748248248248248 0.666666666666667 30.2 30 2 increased urine phosphate level 0.142915379065794 0.297989945872727 0.748248248248248 0.666666666666667 30.2 30 2 increased circulating parathyroid hormone level 0.142915379065794 0.297989945872727 0.748248248248248 0.666666666666667 30.2 30 2 abnormal gastrocnemius morphology 0.142915379065794 0.297989945872727 0.748248248248248 0.666666666666667 30.2 30 2 absent tail 0.142915379065794 0.297989945872727 0.748248248248248 0.666666666666667 30.2 30 2 abnormal nucleotide metabolism 0.142915379065794 0.297989945872727 0.748248248248248 0.666666666666667 30.2 30 2 decreased left ventricle systolic pressure 0.142915379065794 0.297989945872727 0.748248248248248 0.666666666666667 30.2 30 2 bowed ulna 0.142915379065794 0.297989945872727 0.748248248248248 0.666666666666667 30.2 30 2 abnormal cochlear outer hair cell physiology 0.142915379065794 0.297989945872727 0.748248248248248 0.666666666666667 30.2 30 2 abnormal patella morphology 0.142915379065794 0.297989945872727 0.748248248248248 0.666666666666667 30.2 30 2 hemoperitoneum 0.142915379065794 0.297989945872727 0.748248248248248 0.666666666666667 30.2 30 2 abnormal thymus corticomedullary boundary morphology 0.142915379065794 0.297989945872727 0.748248248248248 0.666666666666667 30.2 30 2 abnormal epidermal layer morphology 0.000818349654952548 0.00529426467280745 0.748248248248248 0.666666666666667 30.2 30 2 abnormal food intake 0.000818349654952548 0.00529426467280745 0.748248248248248 0.666666666666667 30.2 30 2 increased macrophage cell number 0.00227004269212455 0.0124377339133476 0.748248248248248 0.666666666666667 30.2 30 2 abnormal optic nerve morphology 0.00834377460411216 0.0352678663172965 0.748248248248248 0.666666666666667 30.2 30 2 abnormal cytotoxic T cell physiology 0.00834377460411216 0.0352678663172965 0.748248248248248 0.666666666666667 30.2 30 2 small lens 0.0108802575773905 0.043420712628428 0.748248248248248 0.666666666666667 30.2 30 2 acanthosis 0.0108802575773905 0.043420712628428 0.748248248248248 0.666666666666667 30.2 30 2 abnormal circulating hormone level 0.0108802575773905 0.043420712628428 0.748248248248248 0.666666666666667 30.2 30 2 abnormal hematopoietic system physiology 0.0571148477596431 0.152194090843184 0.748248248248248 0.666666666666667 30.2 30 2 increased incidence of induced tumors 0.0571148477596431 0.152194090843184 0.748248248248248 0.666666666666667 30.2 30 2 abnormal erythrocyte physiology 0.0571148477596431 0.152194090843184 0.748248248248248 0.666666666666667 30.2 30 2 dry skin 0.0571148477596431 0.152194090843184 0.748248248248248 0.666666666666667 30.2 30 2 increased keratinocyte proliferation 0.0571148477596431 0.152194090843184 0.748248248248248 0.666666666666667 30.2 30 2 increased eosinophil cell number 0.00195684207680141 0.0108531653646455 0.74221398818173 0.661290322580645 30.2 30 2 small ovary 0.000224527328184771 0.00174808052851211 0.74002574002574 0.659340659340659 30.2 30 2 increased circulating cholesterol level 3.65545984082612e-07 6.31455302364929e-06 0.739745427245427 0.659090909090909 30.2 30 2 teratozoospermia 0.000288154817759998 0.00212380773089777 0.739745427245427 0.659090909090909 30.2 30 2 abnormal humoral immune response 9.20128730933484e-05 0.000786536157456028 0.737558987558988 0.657142857142857 30.2 30 2 impaired behavioral response to xenobiotic 0.0206309789883147 0.0746466330668114 0.737558987558988 0.657142857142857 30.2 30 2 abnormal serotonin level 0.0270811505115822 0.0874861842825464 0.736556869369369 0.65625 30.2 30 2 abnormal male meiosis 0.00279438901113238 0.0144212503427216 0.735981883522867 0.655737704918033 30.2 30 2 abnormal CD8-positive, alpha-beta T cell physiology 0.0356688565964182 0.111605384633447 0.735347416381899 0.655172413793103 30.2 30 2 decreased inflammatory response 0.000524602141762699 0.00361982753851516 0.734886672386672 0.654761904761905 30.2 30 2 decreased body temperature 0.00605037289278274 0.0271911518894256 0.733858858858859 0.653846153846154 30.2 30 2 abnormal leukocyte cell number 0.0471718385106368 0.132438456578514 0.733858858858859 0.653846153846154 30.2 30 2 abnormal stomach morphology 0.0471718385106368 0.132438456578514 0.733858858858859 0.653846153846154 30.2 30 2 small seminal vesicle 0.0471718385106368 0.132438456578514 0.733858858858859 0.653846153846154 30.2 30 2 abnormal nerve conduction 0.0471718385106368 0.132438456578514 0.733858858858859 0.653846153846154 30.2 30 2 abnormal circulating insulin level 0.062696721159975 0.164947746044884 0.731981981981982 0.652173913043478 30.2 30 2 pancreas inflammation 0.062696721159975 0.164947746044884 0.731981981981982 0.652173913043478 30.2 30 2 abnormal lens development 0.062696721159975 0.164947746044884 0.731981981981982 0.652173913043478 30.2 30 2 abnormal hepatocyte physiology 0.062696721159975 0.164947746044884 0.731981981981982 0.652173913043478 30.2 30 2 impaired macrophage phagocytosis 0.0132604138079414 0.0504362069529882 0.730847126195963 0.651162790697674 30.2 30 2 skin lesions 0.0030682227554655 0.0158016648120506 0.730432813766147 0.650793650793651 30.2 30 2 brain inflammation 0.0838539872849883 0.203729223570127 0.729542042042042 0.65 30.2 30 2 abnormal dopamine level 0.0838539872849883 0.203729223570127 0.729542042042042 0.65 30.2 30 2 abnormal Peyer's patch T cell area morphology 0.0838539872849883 0.203729223570127 0.729542042042042 0.65 30.2 30 2 decreased skin tensile strength 0.0838539872849883 0.203729223570127 0.729542042042042 0.65 30.2 30 2 enhanced behavioral response to xenobiotic 0.0838539872849883 0.203729223570127 0.729542042042042 0.65 30.2 30 2 abnormal cytokine secretion 6.10588318256969e-06 7.30979507278039e-05 0.728813228813229 0.649350649350649 30.2 30 2 decreased width of hypertrophic chondrocyte zone 0.0225816805801699 0.0783508978418117 0.728025322619917 0.648648648648649 30.2 30 2 increased neutrophil cell number 1.26536338365805e-05 0.000138660414839181 0.72760691726209 0.648275862068965 30.2 30 2 decreased susceptibility to injury 0.00259923756071521 0.0136028374018789 0.726240946829182 0.647058823529412 30.2 30 2 abnormal retinal photoreceptor morphology 0.0295751083158481 0.093124154348952 0.726240946829182 0.647058823529412 30.2 30 2 decreased osteoblast cell number 0.0295751083158481 0.093124154348952 0.726240946829182 0.647058823529412 30.2 30 2 increased susceptibility to weight gain 0.0295751083158481 0.093124154348952 0.726240946829182 0.647058823529412 30.2 30 2 abnormal urinary bladder morphology 0.113060060757667 0.242132502053119 0.726240946829182 0.647058823529412 30.2 30 2 nephrocalcinosis 0.113060060757667 0.242132502053119 0.726240946829182 0.647058823529412 30.2 30 2 increased regulatory T cell number 0.113060060757667 0.242132502053119 0.726240946829182 0.647058823529412 30.2 30 2 pancytopenia 0.113060060757667 0.242132502053119 0.726240946829182 0.647058823529412 30.2 30 2 increased circulating magnesium level 0.113060060757667 0.242132502053119 0.726240946829182 0.647058823529412 30.2 30 2 abnormal response/metabolism to endogenous compounds 0.00103686588597049 0.0063605521365021 0.725435801655314 0.646341463414634 30.2 30 2 decreased food intake 0.00133107186892189 0.00796881173030853 0.724569506215076 0.645569620253165 30.2 30 2 decreased double-negative T cell number 0.0388486321790132 0.117205545840261 0.724111207982176 0.645161290322581 30.2 30 2 decreased susceptibility to bacterial infection induced morbidity/mortality 0.0388486321790132 0.117205545840261 0.724111207982176 0.645161290322581 30.2 30 2 increased susceptibility to parasitic infection 0.000685968588797267 0.00451414514453228 0.723306639973307 0.644444444444444 30.2 30 2 increased circulating corticosterone level 0.0144393624185878 0.0542157192697921 0.723306639973307 0.644444444444444 30.2 30 2 reddish skin 0.0512079696246162 0.136967553162616 0.721525096525096 0.642857142857143 30.2 30 2 abnormal ovulation 0.0512079696246162 0.136967553162616 0.721525096525096 0.642857142857143 30.2 30 2 abnormal retinal inner nuclear layer morphology 0.0512079696246162 0.136967553162616 0.721525096525096 0.642857142857143 30.2 30 2 enhanced coordination 0.0512079696246162 0.136967553162616 0.721525096525096 0.642857142857143 30.2 30 2 absent atrioventricular cushions 0.154099336439077 0.307149118102728 0.721525096525096 0.642857142857143 30.2 30 2 abnormal zigzag hair morphology 0.154099336439077 0.307149118102728 0.721525096525096 0.642857142857143 30.2 30 2 abnormal fluid regulation 0.154099336439077 0.307149118102728 0.721525096525096 0.642857142857143 30.2 30 2 abnormal olfactory system physiology 0.154099336439077 0.307149118102728 0.721525096525096 0.642857142857143 30.2 30 2 increased lactate dehydrogenase level 0.154099336439077 0.307149118102728 0.721525096525096 0.642857142857143 30.2 30 2 decreased coping response 0.154099336439077 0.307149118102728 0.721525096525096 0.642857142857143 30.2 30 2 decreased vascular permeability 0.154099336439077 0.307149118102728 0.721525096525096 0.642857142857143 30.2 30 2 abnormal uterus development 0.154099336439077 0.307149118102728 0.721525096525096 0.642857142857143 30.2 30 2 enlarged stomach 0.154099336439077 0.307149118102728 0.721525096525096 0.642857142857143 30.2 30 2 increased B-1 B cell number 0.154099336439077 0.307149118102728 0.721525096525096 0.642857142857143 30.2 30 2 decreased CNS synapse formation 0.154099336439077 0.307149118102728 0.721525096525096 0.642857142857143 30.2 30 2 abnormal renal reabsorbtion 0.154099336439077 0.307149118102728 0.721525096525096 0.642857142857143 30.2 30 2 decreased eosinophil cell number 0.00467911061416549 0.0221912062015951 0.719019801051051 0.640625 30.2 30 2 increased susceptibility to bacterial infection induced morbidity/mortality 0.0030550704053014 0.0157502334366575 0.717071237904571 0.638888888888889 30.2 30 2 impaired wound healing 0.0319730226544309 0.100483757236762 0.717071237904571 0.638888888888889 30.2 30 2 obese 0.00256525229233633 0.0134621626100983 0.714236964236964 0.636363636363636 30.2 30 2 abnormal circadian rhythm 0.020251099189002 0.0733254865103967 0.714236964236964 0.636363636363636 30.2 30 2 diarrhea 0.0418619111503853 0.126220004832222 0.714236964236964 0.636363636363636 30.2 30 2 increased coping response 0.0901800143545796 0.216946601264039 0.714236964236964 0.636363636363636 30.2 30 2 abnormal circulating lipid level 0.0901800143545796 0.216946601264039 0.714236964236964 0.636363636363636 30.2 30 2 abnormal large intestine morphology 0.213282865844923 0.378796256848557 0.714236964236964 0.636363636363636 30.2 30 2 abnormal glossopharyngeal ganglion morphology 0.213282865844923 0.378796256848557 0.714236964236964 0.636363636363636 30.2 30 2 abnormal hemoglobin 0.213282865844923 0.378796256848557 0.714236964236964 0.636363636363636 30.2 30 2 abnormal hypothalamus secretion 0.213282865844923 0.378796256848557 0.714236964236964 0.636363636363636 30.2 30 2 vasculitis 0.213282865844923 0.378796256848557 0.714236964236964 0.636363636363636 30.2 30 2 abnormal primary sex determination 0.213282865844923 0.378796256848557 0.714236964236964 0.636363636363636 30.2 30 2 abnormal bronchiole morphology 0.213282865844923 0.378796256848557 0.714236964236964 0.636363636363636 30.2 30 2 increased circulating triiodothyronine level 0.213282865844923 0.378796256848557 0.714236964236964 0.636363636363636 30.2 30 2 enhanced behavioral response to addictive substance 0.213282865844923 0.378796256848557 0.714236964236964 0.636363636363636 30.2 30 2 palatal shelf hypoplasia 0.213282865844923 0.378796256848557 0.714236964236964 0.636363636363636 30.2 30 2 decreased palatine bone horizontal plate size 0.213282865844923 0.378796256848557 0.714236964236964 0.636363636363636 30.2 30 2 increased number of Howell-Jolly bodies 0.213282865844923 0.378796256848557 0.714236964236964 0.636363636363636 30.2 30 2 chylous ascites 0.213282865844923 0.378796256848557 0.714236964236964 0.636363636363636 30.2 30 2 abnormal hair growth 0.0129565121640875 0.0493180168449391 0.712274774774775 0.634615384615385 30.2 30 2 arrested B cell differentiation 0.0263218662787019 0.0850885540848225 0.711748333699553 0.634146341463415 30.2 30 2 abnormal T cell differentiation 0.000728515231991943 0.00478779825516501 0.711206255760711 0.633663366336634 30.2 30 2 abnormal eye physiology 0.00835182201137296 0.035271913842598 0.710835835835836 0.633333333333333 30.2 30 2 abnormal hair cycle 0.0549659556044191 0.14686124013533 0.710835835835836 0.633333333333333 30.2 30 2 abnormal epidermis stratum corneum morphology 0.0167525205107059 0.0623364170087972 0.710072317215174 0.63265306122449 30.2 30 2 abnormal inhibitory postsynaptic currents 0.00541490773012003 0.0245571248471715 0.709735470764883 0.632352941176471 30.2 30 2 flaky skin 0.120747705116427 0.257819670795805 0.70886676149834 0.631578947368421 30.2 30 2 shiny skin 0.120747705116427 0.257819670795805 0.70886676149834 0.631578947368421 30.2 30 2 maternal imprinting 0.120747705116427 0.257819670795805 0.70886676149834 0.631578947368421 30.2 30 2 abnormal optic vesicle formation 0.120747705116427 0.257819670795805 0.70886676149834 0.631578947368421 30.2 30 2 Leydig cell hypoplasia 0.120747705116427 0.257819670795805 0.70886676149834 0.631578947368421 30.2 30 2 decreased liver glycogen level 0.120747705116427 0.257819670795805 0.70886676149834 0.631578947368421 30.2 30 2 delayed wound healing 0.0216847725301663 0.0770583880982695 0.707582582582583 0.630434782608696 30.2 30 2 wrinkled skin 0.0724143147508775 0.1851290934664 0.706678901123346 0.62962962962963 30.2 30 2 abnormal intestinal mucosa morphology 0.0281035178623198 0.0896380288833512 0.704745443117536 0.627906976744186 30.2 30 2 head bobbing 0.0364714208389094 0.112799152234824 0.701482732732733 0.625 30.2 30 2 increased susceptibility to weight loss 0.0364714208389094 0.112799152234824 0.701482732732733 0.625 30.2 30 2 abnormal crypts of Lieberkuhn morphology 0.0584611016247316 0.155531540418738 0.701482732732733 0.625 30.2 30 2 increased dopamine level 0.0584611016247316 0.155531540418738 0.701482732732733 0.625 30.2 30 2 abnormal long term potentiation 0.0584611016247316 0.155531540418738 0.701482732732733 0.625 30.2 30 2 abnormal startle reflex 0.0957828917524851 0.228986009835951 0.701482732732733 0.625 30.2 30 2 abnormal meiosis 0.163008959572032 0.324128526726962 0.701482732732733 0.625 30.2 30 2 large intestinal inflammation 0.163008959572032 0.324128526726962 0.701482732732733 0.625 30.2 30 2 small epididymis 0.163008959572032 0.324128526726962 0.701482732732733 0.625 30.2 30 2 abnormal epididymis epithelium morphology 0.163008959572032 0.324128526726962 0.701482732732733 0.625 30.2 30 2 abnormal Langerhans cell physiology 0.163008959572032 0.324128526726962 0.701482732732733 0.625 30.2 30 2 decreased adipocyte glucose uptake 0.163008959572032 0.324128526726962 0.701482732732733 0.625 30.2 30 2 absent pre-B cells 0.302214640657639 0.473548925124962 0.701482732732733 0.625 30.2 30 2 failure of vascular branching 0.302214640657639 0.473548925124962 0.701482732732733 0.625 30.2 30 2 pointed snout 0.302214640657639 0.473548925124962 0.701482732732733 0.625 30.2 30 2 abnormal esophageal epithelium morphology 0.302214640657639 0.473548925124962 0.701482732732733 0.625 30.2 30 2 abnormal cecum morphology 0.302214640657639 0.473548925124962 0.701482732732733 0.625 30.2 30 2 abnormal hypoglossal nerve morphology 0.302214640657639 0.473548925124962 0.701482732732733 0.625 30.2 30 2 spinning 0.302214640657639 0.473548925124962 0.701482732732733 0.625 30.2 30 2 abnormal drinking behavior 0.302214640657639 0.473548925124962 0.701482732732733 0.625 30.2 30 2 abnormal circulating calcium level 0.302214640657639 0.473548925124962 0.701482732732733 0.625 30.2 30 2 abnormal secondary sex determination 0.302214640657639 0.473548925124962 0.701482732732733 0.625 30.2 30 2 abnormal respiratory mucosa goblet cell morphology 0.302214640657639 0.473548925124962 0.701482732732733 0.625 30.2 30 2 vascular smooth muscle hypertrophy 0.302214640657639 0.473548925124962 0.701482732732733 0.625 30.2 30 2 absent tympanic ring 0.302214640657639 0.473548925124962 0.701482732732733 0.625 30.2 30 2 abnormal cellular cholesterol metabolism 0.302214640657639 0.473548925124962 0.701482732732733 0.625 30.2 30 2 abnormal umbilical artery morphology 0.302214640657639 0.473548925124962 0.701482732732733 0.625 30.2 30 2 increased cardiac output 0.302214640657639 0.473548925124962 0.701482732732733 0.625 30.2 30 2 hair follicle degeneration 0.302214640657639 0.473548925124962 0.701482732732733 0.625 30.2 30 2 abnormal forelimb zeugopod morphology 0.302214640657639 0.473548925124962 0.701482732732733 0.625 30.2 30 2 abnormal vestibular labyrinth morphology 0.302214640657639 0.473548925124962 0.701482732732733 0.625 30.2 30 2 ectrodactyly 0.302214640657639 0.473548925124962 0.701482732732733 0.625 30.2 30 2 Sertoli cell hypoplasia 0.302214640657639 0.473548925124962 0.701482732732733 0.625 30.2 30 2 absent outer ear 0.302214640657639 0.473548925124962 0.701482732732733 0.625 30.2 30 2 abnormal thymus epithelium morphology 0.302214640657639 0.473548925124962 0.701482732732733 0.625 30.2 30 2 abnormal corneocyte envelope morphology 0.302214640657639 0.473548925124962 0.701482732732733 0.625 30.2 30 2 skin fibrosis 0.302214640657639 0.473548925124962 0.701482732732733 0.625 30.2 30 2 abnormal lateral plate mesoderm morphology 0.302214640657639 0.473548925124962 0.701482732732733 0.625 30.2 30 2 abnormal brain ependyma morphology 0.302214640657639 0.473548925124962 0.701482732732733 0.625 30.2 30 2 heart right ventricle hypoplasia 0.302214640657639 0.473548925124962 0.701482732732733 0.625 30.2 30 2 abnormal hepatic vein morphology 0.302214640657639 0.473548925124962 0.701482732732733 0.625 30.2 30 2 increased heart right ventricle size 0.302214640657639 0.473548925124962 0.701482732732733 0.625 30.2 30 2 abnormal heart right ventricle pressure 0.302214640657639 0.473548925124962 0.701482732732733 0.625 30.2 30 2 increased airway resistance 0.302214640657639 0.473548925124962 0.701482732732733 0.625 30.2 30 2 increased circulating lactate level 0.302214640657639 0.473548925124962 0.701482732732733 0.625 30.2 30 2 enhanced long term potentiation 0.0147568992281393 0.0552828114909587 0.701482732732733 0.625 30.2 30 2 hyperkeratosis 0.00787900617040345 0.0336753055822656 0.699449449449449 0.623188405797101 30.2 30 2 abnormal long bone metaphysis morphology 0.047401656062145 0.132438456578514 0.697690934177421 0.621621621621622 30.2 30 2 abnormal breathing pattern 0.047401656062145 0.132438456578514 0.697690934177421 0.621621621621622 30.2 30 2 abnormal pancreatic beta cell physiology 0.047401656062145 0.132438456578514 0.697690934177421 0.621621621621622 30.2 30 2 dermatitis 0.0156376252197156 0.0585381380497256 0.696644920782852 0.620689655172414 30.2 30 2 abnormal circulating glucose level 0.0766356091253038 0.195065642825297 0.696644920782852 0.620689655172414 30.2 30 2 decreased granulocyte number 0.0766356091253038 0.195065642825297 0.696644920782852 0.620689655172414 30.2 30 2 focal hair loss 0.0766356091253038 0.195065642825297 0.696644920782852 0.620689655172414 30.2 30 2 stomach inflammation 0.0766356091253038 0.195065642825297 0.696644920782852 0.620689655172414 30.2 30 2 arrest of spermatogenesis 0.00450137647805711 0.0213686526510822 0.694801944801945 0.619047619047619 30.2 30 2 abnormal anxiety-related response 0.127305089013674 0.270668447611871 0.694801944801945 0.619047619047619 30.2 30 2 increased acute inflammation 0.127305089013674 0.270668447611871 0.694801944801945 0.619047619047619 30.2 30 2 abnormal bone remodeling 0.0617098234215608 0.162695480403956 0.693229994700583 0.617647058823529 30.2 30 2 decreased pancreatic beta cell number 0.0617098234215608 0.162695480403956 0.693229994700583 0.617647058823529 30.2 30 2 abnormal innervation 0.0314806025505856 0.0989987343167909 0.692527634016996 0.617021276595745 30.2 30 2 increased systemic arterial blood pressure 0.0314806025505856 0.0989987343167909 0.692527634016996 0.617021276595745 30.2 30 2 decreased monocyte cell number 0.0135931174475983 0.0512316358346981 0.690690690690691 0.615384615384615 30.2 30 2 no spontaneous movement 0.100758352763623 0.230543916094347 0.690690690690691 0.615384615384615 30.2 30 2 absent myocardial trabeculae 0.222480937188238 0.378796256848557 0.690690690690691 0.615384615384615 30.2 30 2 small trigeminal ganglion 0.222480937188238 0.378796256848557 0.690690690690691 0.615384615384615 30.2 30 2 abnormal digestion 0.222480937188238 0.378796256848557 0.690690690690691 0.615384615384615 30.2 30 2 abnormal coping response 0.222480937188238 0.378796256848557 0.690690690690691 0.615384615384615 30.2 30 2 abnormal GABAergic neuron morphology 0.222480937188238 0.378796256848557 0.690690690690691 0.615384615384615 30.2 30 2 abnormal afterhyperpolarization 0.222480937188238 0.378796256848557 0.690690690690691 0.615384615384615 30.2 30 2 abnormal retinal inner plexiform layer morphology 0.222480937188238 0.378796256848557 0.690690690690691 0.615384615384615 30.2 30 2 decreased luteinizing hormone level 0.222480937188238 0.378796256848557 0.690690690690691 0.615384615384615 30.2 30 2 abnormal vertebral arch development 0.222480937188238 0.378796256848557 0.690690690690691 0.615384615384615 30.2 30 2 increased circulating ammonia level 0.222480937188238 0.378796256848557 0.690690690690691 0.615384615384615 30.2 30 2 small pituitary gland 0.222480937188238 0.378796256848557 0.690690690690691 0.615384615384615 30.2 30 2 increased renin activity 0.222480937188238 0.378796256848557 0.690690690690691 0.615384615384615 30.2 30 2 abnormal hair follicle inner root sheath morphology 0.222480937188238 0.378796256848557 0.690690690690691 0.615384615384615 30.2 30 2 increased susceptibility to pharmacologically induced seizures 0.00327266733147052 0.0165462601362458 0.689791353853854 0.614583333333333 30.2 30 2 decreased susceptibility to induced arthritis 0.0211217968953919 0.0752728793370879 0.689176018123386 0.614035087719298 30.2 30 2 abnormal systemic arterial blood pressure 0.0647286628574517 0.166765974995247 0.685894227560894 0.611111111111111 30.2 30 2 abnormal heart shape 0.170208070920891 0.337903093707676 0.685894227560894 0.611111111111111 30.2 30 2 increased susceptibility to autoimmune disorder 0.170208070920891 0.337903093707676 0.685894227560894 0.611111111111111 30.2 30 2 jerky movement 0.170208070920891 0.337903093707676 0.685894227560894 0.611111111111111 30.2 30 2 abnormal sperm axoneme morphology 0.170208070920891 0.337903093707676 0.685894227560894 0.611111111111111 30.2 30 2 scaly skin 0.0523300998392337 0.139893738151632 0.684373397788032 0.609756097560976 30.2 30 2 increased susceptibility to age related obesity 0.132931803768409 0.279516366757326 0.683183183183183 0.608695652173913 30.2 30 2 abnormal palatal shelf fusion at midline 0.132931803768409 0.279516366757326 0.683183183183183 0.608695652173913 30.2 30 2 abnormal spleen germinal center morphology 0.105187757218736 0.231757791037737 0.681440368940369 0.607142857142857 30.2 30 2 myeloid hyperplasia 0.0839983177391103 0.203729223570127 0.68022568022568 0.606060606060606 30.2 30 2 abnormal immune system physiology 0.00187262511943045 0.0104280597254153 0.67885425748329 0.604838709677419 30.2 30 2 abnormal digestive system physiology 0.0460279462220351 0.132438456578514 0.673423423423423 0.6 30.2 30 2 salivary gland inflammation 0.109140089406631 0.235947662095414 0.673423423423423 0.6 30.2 30 2 abnormal estrous cycle 0.109140089406631 0.235947662095414 0.673423423423423 0.6 30.2 30 2 abnormal vertebrae development 0.137784174930843 0.289597072362037 0.673423423423423 0.6 30.2 30 2 abnormal hair texture 0.176088281863586 0.349297927540408 0.673423423423423 0.6 30.2 30 2 increased urine calcium level 0.176088281863586 0.349297927540408 0.673423423423423 0.6 30.2 30 2 decreased salivation 0.229271371974123 0.389291834665959 0.673423423423423 0.6 30.2 30 2 abnormal epidermis stratum spinosum morphology 0.229271371974123 0.389291834665959 0.673423423423423 0.6 30.2 30 2 no suckling reflex 0.229271371974123 0.389291834665959 0.673423423423423 0.6 30.2 30 2 audiogenic seizures 0.229271371974123 0.389291834665959 0.673423423423423 0.6 30.2 30 2 abnormal seizure response to electrical stimulation 0.229271371974123 0.389291834665959 0.673423423423423 0.6 30.2 30 2 increased airway responsiveness 0.229271371974123 0.389291834665959 0.673423423423423 0.6 30.2 30 2 arthritis 0.229271371974123 0.389291834665959 0.673423423423423 0.6 30.2 30 2 lactation failure 0.229271371974123 0.389291834665959 0.673423423423423 0.6 30.2 30 2 abnormal auchene hair morphology 0.308326096047724 0.481306033209108 0.673423423423423 0.6 30.2 30 2 absent maxillary shelf 0.308326096047724 0.481306033209108 0.673423423423423 0.6 30.2 30 2 absent palatine bone horizontal plate 0.308326096047724 0.481306033209108 0.673423423423423 0.6 30.2 30 2 absent trophoblast giant cells 0.308326096047724 0.481306033209108 0.673423423423423 0.6 30.2 30 2 abnormal pituitary secretion 0.308326096047724 0.481306033209108 0.673423423423423 0.6 30.2 30 2 rickets 0.308326096047724 0.481306033209108 0.673423423423423 0.6 30.2 30 2 abnormal cochlear inner hair cell physiology 0.308326096047724 0.481306033209108 0.673423423423423 0.6 30.2 30 2 crystalluria 0.308326096047724 0.481306033209108 0.673423423423423 0.6 30.2 30 2 impaired behavioral response to morphine 0.308326096047724 0.481306033209108 0.673423423423423 0.6 30.2 30 2 increased serotonin level 0.308326096047724 0.481306033209108 0.673423423423423 0.6 30.2 30 2 umbilical hernia 0.308326096047724 0.481306033209108 0.673423423423423 0.6 30.2 30 2 abnormal gametogenesis 0.0748147658305208 0.191069537991191 0.663220038220038 0.590909090909091 30.2 30 2 abnormal photoreceptor outer segment morphology 0.0748147658305208 0.191069537991191 0.663220038220038 0.590909090909091 30.2 30 2 intestinal ulcer 0.180930196854589 0.353849510413767 0.663220038220038 0.590909090909091 30.2 30 2 increased activated T cell number 0.180930196854589 0.353849510413767 0.663220038220038 0.590909090909091 30.2 30 2 abnormal lens fiber morphology 0.0928261514497977 0.222886948829497 0.661911911911912 0.58974358974359 30.2 30 2 abnormal leukocyte adhesion 0.0928261514497977 0.222886948829497 0.661911911911912 0.58974358974359 30.2 30 2 enlarged sebaceous gland 0.234364529306837 0.397261851210056 0.660219042571984 0.588235294117647 30.2 30 2 increased aggression towards mice 0.234364529306837 0.397261851210056 0.660219042571984 0.588235294117647 30.2 30 2 decreased growth hormone level 0.234364529306837 0.397261851210056 0.660219042571984 0.588235294117647 30.2 30 2 abnormal tendon morphology 0.234364529306837 0.397261851210056 0.660219042571984 0.588235294117647 30.2 30 2 abnormal circulating chemokine level 0.234364529306837 0.397261851210056 0.660219042571984 0.588235294117647 30.2 30 2 abnormal reflex 0.118678034688752 0.254054742933107 0.654717217217217 0.583333333333333 30.2 30 2 decreased digestive secretion 0.311797347335702 0.484898969363901 0.654717217217217 0.583333333333333 30.2 30 2 abnormal glossopharyngeal nerve morphology 0.311797347335702 0.484898969363901 0.654717217217217 0.583333333333333 30.2 30 2 increased litter size 0.311797347335702 0.484898969363901 0.654717217217217 0.583333333333333 30.2 30 2 decreased circulating ketone body level 0.311797347335702 0.484898969363901 0.654717217217217 0.583333333333333 30.2 30 2 abnormal B cell proliferation 0.311797347335702 0.484898969363901 0.654717217217217 0.583333333333333 30.2 30 2 abnormal amacrine cell morphology 0.311797347335702 0.484898969363901 0.654717217217217 0.583333333333333 30.2 30 2 decreased keratinocyte proliferation 0.311797347335702 0.484898969363901 0.654717217217217 0.583333333333333 30.2 30 2 hydrometra 0.311797347335702 0.484898969363901 0.654717217217217 0.583333333333333 30.2 30 2 abnormal behavioral response to addictive substance 0.311797347335702 0.484898969363901 0.654717217217217 0.583333333333333 30.2 30 2 impaired behavioral response to cocaine 0.311797347335702 0.484898969363901 0.654717217217217 0.583333333333333 30.2 30 2 decreased compensatory feeding amount 0.311797347335702 0.484898969363901 0.654717217217217 0.583333333333333 30.2 30 2 decreased chemically-elicited antinociception 0.238216073902029 0.403378137393667 0.649794531373479 0.578947368421053 30.2 30 2 abnormal response to novelty 0.238216073902029 0.403378137393667 0.649794531373479 0.578947368421053 30.2 30 2 abnormal photoreceptor inner segment morphology 0.238216073902029 0.403378137393667 0.649794531373479 0.578947368421053 30.2 30 2 abnormal leukocyte migration 0.082350458433294 0.203729223570127 0.647522522522523 0.576923076923077 30.2 30 2 abnormal ocular fundus morphology 0.188273932431597 0.365883911659061 0.647522522522523 0.576923076923077 30.2 30 2 impaired ovarian folliculogenesis 0.123518759771942 0.263623264635526 0.645364114114114 0.575 30.2 30 2 abnormal hair cuticle 0.313656404853786 0.486307181133969 0.641355641355641 0.571428571428571 30.2 30 2 abnormal pancreas development 0.313656404853786 0.486307181133969 0.641355641355641 0.571428571428571 30.2 30 2 abnormal squamosal bone morphology 0.313656404853786 0.486307181133969 0.641355641355641 0.571428571428571 30.2 30 2 abnormal positive T cell selection 0.313656404853786 0.486307181133969 0.641355641355641 0.571428571428571 30.2 30 2 abnormal T cell activation 0.0610795690156636 0.161204698065213 0.637022157292428 0.567567567567568 30.2 30 2 arrested T cell differentiation 0.193362883893863 0.375626843956254 0.636011011011011 0.566666666666667 30.2 30 2 abnormal retinal cone cell morphology 0.243328107866622 0.411894296235605 0.634384384384384 0.565217391304348 30.2 30 2 abnormal bone marrow cell number 0.314465902205382 0.486307181133969 0.631334459459459 0.5625 30.2 30 2 delayed hair appearance 0.314465902205382 0.486307181133969 0.631334459459459 0.5625 30.2 30 2 mixed cellular infiltration to dermis 0.314465902205382 0.486307181133969 0.631334459459459 0.5625 30.2 30 2 abnormal intestinal absorption 0.314465902205382 0.486307181133969 0.631334459459459 0.5625 30.2 30 2 paternal imprinting 0.314465902205382 0.486307181133969 0.631334459459459 0.5625 30.2 30 2 decreased circulating prolactin level 0.314465902205382 0.486307181133969 0.631334459459459 0.5625 30.2 30 2 abnormal intestinal lipid absorption 0.314465902205382 0.486307181133969 0.631334459459459 0.5625 30.2 30 2 decreased fibroblast apoptosis 0.314465902205382 0.486307181133969 0.631334459459459 0.5625 30.2 30 2 impaired natural killer cell mediated cytotoxicity 0.108843011615454 0.235947662095414 0.630103787998525 0.56140350877193 30.2 30 2 abnormal NK cell physiology 0.110992648855436 0.238217613483949 0.625584600994437 0.557377049180328 30.2 30 2 decreased susceptibility to pharmacologically induced seizures 0.246133792447937 0.416360291543179 0.62354020687354 0.555555555555556 30.2 30 2 abnormal single cell response 0.246133792447937 0.416360291543179 0.62354020687354 0.555555555555556 30.2 30 2 abnormal megakaryocyte differentiation 0.314560102289269 0.486307181133969 0.62354020687354 0.555555555555556 30.2 30 2 absent spleen 0.314560102289269 0.486307181133969 0.62354020687354 0.555555555555556 30.2 30 2 abnormal iron level 0.314560102289269 0.486307181133969 0.62354020687354 0.555555555555556 30.2 30 2 abnormal white adipose tissue morphology 0.314560102289269 0.486307181133969 0.62354020687354 0.555555555555556 30.2 30 2 renal tubular acidosis 0.429358555241584 0.557980240694288 0.62354020687354 0.555555555555556 30.2 30 2 deformed nails 0.429358555241584 0.557980240694288 0.62354020687354 0.555555555555556 30.2 30 2 thick tail 0.429358555241584 0.557980240694288 0.62354020687354 0.555555555555556 30.2 30 2 small geniculate ganglion 0.429358555241584 0.557980240694288 0.62354020687354 0.555555555555556 30.2 30 2 abnormal vagina orifice morphology 0.429358555241584 0.557980240694288 0.62354020687354 0.555555555555556 30.2 30 2 multifocal hepatic necrosis 0.429358555241584 0.557980240694288 0.62354020687354 0.555555555555556 30.2 30 2 abnormal taste sensitivity 0.429358555241584 0.557980240694288 0.62354020687354 0.555555555555556 30.2 30 2 abnormal vomeronasal organ morphology 0.429358555241584 0.557980240694288 0.62354020687354 0.555555555555556 30.2 30 2 abnormal thymus lobule morphology 0.429358555241584 0.557980240694288 0.62354020687354 0.555555555555556 30.2 30 2 decreased circulating bicarbonate level 0.429358555241584 0.557980240694288 0.62354020687354 0.555555555555556 30.2 30 2 genetic imprinting 0.429358555241584 0.557980240694288 0.62354020687354 0.555555555555556 30.2 30 2 yellow coat color 0.429358555241584 0.557980240694288 0.62354020687354 0.555555555555556 30.2 30 2 decreased susceptibility to induced choroidal neovascularization 0.429358555241584 0.557980240694288 0.62354020687354 0.555555555555556 30.2 30 2 abnormal bony labyrinth 0.429358555241584 0.557980240694288 0.62354020687354 0.555555555555556 30.2 30 2 decreased vestibular hair cell number 0.429358555241584 0.557980240694288 0.62354020687354 0.555555555555556 30.2 30 2 abnormal retinal development 0.429358555241584 0.557980240694288 0.62354020687354 0.555555555555556 30.2 30 2 reduced AMPA-mediated synaptic currents 0.429358555241584 0.557980240694288 0.62354020687354 0.555555555555556 30.2 30 2 increased myeloid cell number 0.429358555241584 0.557980240694288 0.62354020687354 0.555555555555556 30.2 30 2 increased bone mineralization 0.429358555241584 0.557980240694288 0.62354020687354 0.555555555555556 30.2 30 2 increased endoplasmic reticulum stress 0.429358555241584 0.557980240694288 0.62354020687354 0.555555555555556 30.2 30 2 abnormal circulating cytokine level 0.314150041949015 0.486307181133969 0.617304804804805 0.55 30.2 30 2 nuclear cataracts 0.314150041949015 0.486307181133969 0.617304804804805 0.55 30.2 30 2 autoimmune response 0.247455168716997 0.418453250974527 0.615494526784849 0.548387096774194 30.2 30 2 decreased susceptibility to viral infection induced morbidity/mortality 0.313375349567458 0.486307181133969 0.612203112203112 0.545454545454545 30.2 30 2 abnormal sebaceous gland morphology 0.422377972291086 0.557980240694288 0.612203112203112 0.545454545454545 30.2 30 2 social withdrawal 0.422377972291086 0.557980240694288 0.612203112203112 0.545454545454545 30.2 30 2 secondary sex reversal 0.422377972291086 0.557980240694288 0.612203112203112 0.545454545454545 30.2 30 2 abnormal frequency of paradoxical sleep 0.422377972291086 0.557980240694288 0.612203112203112 0.545454545454545 30.2 30 2 rectal hemorrhage 0.422377972291086 0.557980240694288 0.612203112203112 0.545454545454545 30.2 30 2 abnormal nerve fiber response 0.422377972291086 0.557980240694288 0.612203112203112 0.545454545454545 30.2 30 2 enlarged placenta 0.422377972291086 0.557980240694288 0.612203112203112 0.545454545454545 30.2 30 2 shortened PR interval 0.422377972291086 0.557980240694288 0.612203112203112 0.545454545454545 30.2 30 2 abnormal dendritic cell chemotaxis 0.422377972291086 0.557980240694288 0.612203112203112 0.545454545454545 30.2 30 2 abnormal phrenic nerve innervation pattern to diaphragm 0.422377972291086 0.557980240694288 0.612203112203112 0.545454545454545 30.2 30 2 decreased colon length 0.422377972291086 0.557980240694288 0.612203112203112 0.545454545454545 30.2 30 2 abnormal membranous labyrinth morphology 0.415999825841077 0.557980240694288 0.604354354354354 0.538461538461538 30.2 30 2 absent trabeculae carneae 0.415999825841077 0.557980240694288 0.604354354354354 0.538461538461538 30.2 30 2 abnormal mast cell morphology 0.415999825841077 0.557980240694288 0.604354354354354 0.538461538461538 30.2 30 2 abnormal sympathetic ganglion morphology 0.415999825841077 0.557980240694288 0.604354354354354 0.538461538461538 30.2 30 2 decreased circulating progesterone level 0.309691521405275 0.4832858591566 0.601270913770914 0.535714285714286 30.2 30 2 decreased chondrocyte number 0.410096442430544 0.557980240694288 0.598598598598599 0.533333333333333 30.2 30 2 altered righting response 0.410096442430544 0.557980240694288 0.598598598598599 0.533333333333333 30.2 30 2 decreased aggression towards males 0.410096442430544 0.557980240694288 0.598598598598599 0.533333333333333 30.2 30 2 abnormal rostral migratory stream morphology 0.410096442430544 0.557980240694288 0.598598598598599 0.533333333333333 30.2 30 2 abnormal dendritic cell morphology 0.410096442430544 0.557980240694288 0.598598598598599 0.533333333333333 30.2 30 2 decreased regulatory T cell number 0.304915525846073 0.477630585983695 0.594197138314785 0.529411764705882 30.2 30 2 abnormal glutamate-mediated receptor currents 0.404579946716247 0.557980240694288 0.594197138314785 0.529411764705882 30.2 30 2 osteoarthritis 0.399386800497313 0.557980240694288 0.590722301248617 0.526315789473684 30.2 30 2 abnormal behavioral response to xenobiotic 0.399386800497313 0.557980240694288 0.590722301248617 0.526315789473684 30.2 30 2 increased vasoconstriction 0.394469295196449 0.557980240694288 0.587909337909338 0.523809523809524 30.2 30 2 hypoalgesia 0.394469295196449 0.557980240694288 0.587909337909338 0.523809523809524 30.2 30 2 abnormal bile salt homeostasis 0.394469295196449 0.557980240694288 0.587909337909338 0.523809523809524 30.2 30 2 increased bone ossification 0.394469295196449 0.557980240694288 0.587909337909338 0.523809523809524 30.2 30 2 decreased epididymis weight 0.389790522332007 0.557980240694288 0.585585585585586 0.521739130434783 30.2 30 2 impaired conditioned place preference behavior 0.385321228586592 0.557980240694288 0.583633633633634 0.52 30.2 30 2 absent long term depression 0.376920658000637 0.557980240694288 0.58053743398571 0.517241379310345 30.2 30 2 increased susceptibility to induced arthritis 0.376920658000637 0.557980240694288 0.58053743398571 0.517241379310345 30.2 30 2 enlarged epididymis 0.376920658000637 0.557980240694288 0.58053743398571 0.517241379310345 30.2 30 2 abnormal body temperature homeostasis 0.37295369589604 0.557980240694288 0.579288966385741 0.516129032258065 30.2 30 2 abnormal cellular extravasation 0.467249140925851 0.557980240694288 0.561186186186186 0.5 30.2 30 2 abnormal thymocyte activation 0.48462355904561 0.573774918194172 0.561186186186186 0.5 30.2 30 2 decreased circulating growth hormone level 0.505726982655707 0.598333350466621 0.561186186186186 0.5 30.2 30 2 abnormal pancreatic alpha cell morphology 0.505726982655707 0.598333350466621 0.561186186186186 0.5 30.2 30 2 abnormal urinary bladder physiology 0.505726982655707 0.598333350466621 0.561186186186186 0.5 30.2 30 2 abnormal pilomotor reflex 0.532958597246471 0.629503566310824 0.561186186186186 0.5 30.2 30 2 impaired sperm capacitation 0.532958597246471 0.629503566310824 0.561186186186186 0.5 30.2 30 2 abnormal anogenital distance 0.532958597246471 0.629503566310824 0.561186186186186 0.5 30.2 30 2 abnormal respiratory motile cilium morphology 0.532958597246471 0.629503566310824 0.561186186186186 0.5 30.2 30 2 small petrosal ganglion 0.550391014435444 0.648400496522931 0.561186186186186 0.5 30.2 30 2 abnormal optic nerve innervation 0.550391014435444 0.648400496522931 0.561186186186186 0.5 30.2 30 2 abnormal bone healing 0.550391014435444 0.648400496522931 0.561186186186186 0.5 30.2 30 2 intestinal edema 0.550391014435444 0.648400496522931 0.561186186186186 0.5 30.2 30 2 increased defecation amount 0.550391014435444 0.648400496522931 0.561186186186186 0.5 30.2 30 2 decreased prolactin level 0.550391014435444 0.648400496522931 0.561186186186186 0.5 30.2 30 2 abnormal sperm principal piece morphology 0.550391014435444 0.648400496522931 0.561186186186186 0.5 30.2 30 2 protruding tongue 0.550391014435444 0.648400496522931 0.561186186186186 0.5 30.2 30 2 abnormal vasoconstriction 0.518343246828367 0.61282263616234 0.561186186186186 0.5 30.2 30 2 abnormal imprinting 0.518343246828367 0.61282263616234 0.561186186186186 0.5 30.2 30 2 abnormal respiratory motile cilium physiology 0.518343246828367 0.61282263616234 0.561186186186186 0.5 30.2 30 2 abnormal feces composition 0.54287490616209 0.640759823999146 0.538738738738739 0.48 30.2 30 2 decreased acute inflammation 0.54287490616209 0.640759823999146 0.538738738738739 0.48 30.2 30 2 abnormal stomach mucosa morphology 0.54287490616209 0.640759823999146 0.538738738738739 0.48 30.2 30 2 increased susceptibility to fungal infection 0.554188232777753 0.652719331929291 0.536786786786787 0.478260869565217 30.2 30 2 abnormal associative learning 0.566581980726666 0.667158663695896 0.534463034463034 0.476190476190476 30.2 30 2 decreased cytotoxic T cell cytolysis 0.569460614840625 0.670389625847636 0.528175234057587 0.470588235294118 30.2 30 2 distended urinary bladder 0.595635459046337 0.698558795086169 0.528175234057587 0.470588235294118 30.2 30 2 increased alcohol consumption 0.613059200676462 0.713777094164614 0.523773773773774 0.466666666666667 30.2 30 2 increased circulating luteinizing hormone level 0.601866074071498 0.700909110137103 0.521101458601459 0.464285714285714 30.2 30 2 abnormal intercostal muscle morphology 0.633208972736808 0.735971801144645 0.518018018018018 0.461538461538462 30.2 30 2 decreased follicle stimulating hormone level 0.633208972736808 0.735971801144645 0.518018018018018 0.461538461538462 30.2 30 2 abnormal gut flora balance 0.633208972736808 0.735971801144645 0.518018018018018 0.461538461538462 30.2 30 2 variable body spotting 0.657068549555743 0.751647742938565 0.51016926016926 0.454545454545455 30.2 30 2 abnormal brain ependyma motile cilium morphology 0.657068549555743 0.751647742938565 0.51016926016926 0.454545454545455 30.2 30 2 abnormal fertilization 0.696539814692605 0.786767664642723 0.491037912912913 0.4375 30.2 30 2 abnormal prepulse inhibition 0.719358267168139 0.786767664642723 0.481016731016731 0.428571428571429 30.2 30 2 increased fear-related response 0.745718515490938 0.811272603229262 0.467655155155155 0.416666666666667 30.2 30 2 increased placenta weight 0.745718515490938 0.811272603229262 0.467655155155155 0.416666666666667 30.2 30 2 decreased oligodendrocyte number 0.745718515490938 0.811272603229262 0.467655155155155 0.416666666666667 30.2 30 2 joint inflammation 0.790224311495925 0.85501651798439 0.448948948948949 0.4 30.2 30 2 greasy coat 0.790224311495925 0.85501651798439 0.448948948948949 0.4 30.2 30 2 abnormal dopaminergic neuron morphology 0.816036979712268 0.88122074540233 0.431681681681682 0.384615384615385 30.2 30 2 decreased alcohol consumption 0.816036979712268 0.88122074540233 0.431681681681682 0.384615384615385 30.2 30 2 abnormal pituitary gland morphology 0.846435009577917 0.907965899014274 0.42088963963964 0.375 30.2 30 2 abnormal extraembryonic endoderm formation 0.846435009577917 0.907965899014274 0.42088963963964 0.375 30.2 30 2 increased circulating estradiol level 0.846435009577917 0.907965899014274 0.42088963963964 0.375 30.2 30 2 decreased airway responsiveness 0.89039709029822 0.946522547913172 0.408135408135408 0.363636363636364 30.2 30 2 abnormal regulatory T cell physiology 0.988792826355554 1 0.292792792792793 0.260869565217391 30.2 30 2 abnormal lung interstitium morphology 7.27710080930655e-06 0.00013359253330738 1.48381900717528 1 30.4 30 4 osteosclerosis 0.000111672296717208 0.00139941983921438 1.48381900717528 1 30.4 30 4 abnormal posterior semicircular canal morphology 0.000277483034886373 0.00300746004067706 1.48381900717528 1 30.4 30 4 broad head 0.00171301582794472 0.0131923432570046 1.48381900717528 1 30.4 30 4 absent amniotic folds 0.00171301582794472 0.0131923432570046 1.48381900717528 1 30.4 30 4 aorta coarctation 0.00171301582794472 0.0131923432570046 1.48381900717528 1 30.4 30 4 increased cell nucleus count 0.00171301582794472 0.0131923432570046 1.48381900717528 1 30.4 30 4 urolithiasis 0.00171301582794472 0.0131923432570046 1.48381900717528 1 30.4 30 4 abnormal outer hair cell kinocilium morphology 0.00171301582794472 0.0131923432570046 1.48381900717528 1 30.4 30 4 ductus venosus stenosis 0.00171301582794472 0.0131923432570046 1.48381900717528 1 30.4 30 4 absent organ of Corti 0.0105732933517194 0.052497140144515 1.48381900717528 1 30.4 30 4 absent neurocranium 0.0105732933517194 0.052497140144515 1.48381900717528 1 30.4 30 4 abnormal pulmonary trunk morphology 0.0105732933517194 0.052497140144515 1.48381900717528 1 30.4 30 4 kidney vascular congestion 0.0105732933517194 0.052497140144515 1.48381900717528 1 30.4 30 4 dissociated hepatocytes 0.0105732933517194 0.052497140144515 1.48381900717528 1 30.4 30 4 abnormal pineal gland morphology 0.0105732933517194 0.052497140144515 1.48381900717528 1 30.4 30 4 absent lungs 0.0105732933517194 0.052497140144515 1.48381900717528 1 30.4 30 4 decreased sensitivity to skin irradiation 0.0105732933517194 0.052497140144515 1.48381900717528 1 30.4 30 4 skin hyperplasia 0.0105732933517194 0.052497140144515 1.48381900717528 1 30.4 30 4 abnormal respiratory sounds 0.0105732933517194 0.052497140144515 1.48381900717528 1 30.4 30 4 increased hepatic hemangioma incidence 0.0105732933517194 0.052497140144515 1.48381900717528 1 30.4 30 4 improved righting response 0.0105732933517194 0.052497140144515 1.48381900717528 1 30.4 30 4 gastric polyps 0.0105732933517194 0.052497140144515 1.48381900717528 1 30.4 30 4 thyroid hypoplasia 0.0105732933517194 0.052497140144515 1.48381900717528 1 30.4 30 4 absent vas deferens 0.0105732933517194 0.052497140144515 1.48381900717528 1 30.4 30 4 absent uterus 0.0105732933517194 0.052497140144515 1.48381900717528 1 30.4 30 4 abnormal optokinetic reflex 0.0105732933517194 0.052497140144515 1.48381900717528 1 30.4 30 4 abnormal mismatch repair 0.0105732933517194 0.052497140144515 1.48381900717528 1 30.4 30 4 palatal shelf fusion with tongue or mandible 0.0105732933517194 0.052497140144515 1.48381900717528 1 30.4 30 4 increased T follicular helper cell number 0.0105732933517194 0.052497140144515 1.48381900717528 1 30.4 30 4 enlarged aortic valve 0.0105732933517194 0.052497140144515 1.48381900717528 1 30.4 30 4 abnormal blood pressure regulation 0.0105732933517194 0.052497140144515 1.48381900717528 1 30.4 30 4 pale lung 0.0105732933517194 0.052497140144515 1.48381900717528 1 30.4 30 4 pulmonary alveolar edema 0.0105732933517194 0.052497140144515 1.48381900717528 1 30.4 30 4 abnormal nephrogenic mesenchyme morphogenesis 0.0105732933517194 0.052497140144515 1.48381900717528 1 30.4 30 4 abnormal lung alveolus development 0.0105732933517194 0.052497140144515 1.48381900717528 1 30.4 30 4 abnormal circadian regulation of heart rate 0.0105732933517194 0.052497140144515 1.48381900717528 1 30.4 30 4 delayed optic fissure closure 0.0105732933517194 0.052497140144515 1.48381900717528 1 30.4 30 4 abnormal ciliary process morphology 0.0105732933517194 0.052497140144515 1.48381900717528 1 30.4 30 4 abnormal rostral-caudal body axis extension 1.80844967496119e-05 0.000288366574773459 1.48381900717528 1 30.4 30 4 early eyelid opening 0.000689458945875915 0.00621368329888555 1.48381900717528 1 30.4 30 4 abnormal eyelid aperture 0.000689458945875915 0.00621368329888555 1.48381900717528 1 30.4 30 4 elevated level of mitotic sister chromatid exchange 0.000689458945875915 0.00621368329888555 1.48381900717528 1 30.4 30 4 increased left ventricle systolic pressure 0.000689458945875915 0.00621368329888555 1.48381900717528 1 30.4 30 4 stomach epithelial hyperplasia 0.000689458945875915 0.00621368329888555 1.48381900717528 1 30.4 30 4 decreased alveolar lamellar body number 0.000689458945875915 0.00621368329888555 1.48381900717528 1 30.4 30 4 embryo cyst 0.000689458945875915 0.00621368329888555 1.48381900717528 1 30.4 30 4 epidermal necrosis 0.0042559383864803 0.0262695948793294 1.48381900717528 1 30.4 30 4 abnormal lacrimal gland physiology 0.0042559383864803 0.0262695948793294 1.48381900717528 1 30.4 30 4 absent ectoplacental cone 0.0042559383864803 0.0262695948793294 1.48381900717528 1 30.4 30 4 non-obstructive hydrocephaly 0.0042559383864803 0.0262695948793294 1.48381900717528 1 30.4 30 4 decreased posterior semicircular canal size 0.0042559383864803 0.0262695948793294 1.48381900717528 1 30.4 30 4 bile duct inflammation 0.0042559383864803 0.0262695948793294 1.48381900717528 1 30.4 30 4 ureter obstruction 0.0042559383864803 0.0262695948793294 1.48381900717528 1 30.4 30 4 absent cochlear nerve compound action potential 0.0042559383864803 0.0262695948793294 1.48381900717528 1 30.4 30 4 abnormal eyelid development 0.0042559383864803 0.0262695948793294 1.48381900717528 1 30.4 30 4 abnormal intestinal enteroendocrine cell morphology 0.0042559383864803 0.0262695948793294 1.48381900717528 1 30.4 30 4 thymus cortex atrophy 0.0042559383864803 0.0262695948793294 1.48381900717528 1 30.4 30 4 abnormal vertebral artery origin 0.0042559383864803 0.0262695948793294 1.48381900717528 1 30.4 30 4 additional anastomosis between intracranial vertebral arteries 0.0042559383864803 0.0262695948793294 1.48381900717528 1 30.4 30 4 decreased tear production 0.0042559383864803 0.0262695948793294 1.48381900717528 1 30.4 30 4 increased cardiac cell glucose uptake 0.0042559383864803 0.0262695948793294 1.48381900717528 1 30.4 30 4 absent ductus venosus valve 3.8139803722191e-07 9.68668506410098e-06 1.40962805681652 0.95 30.4 30 4 increased cochlear outer hair cell number 1.1740245526401e-05 0.000201405936185672 1.39108031922683 0.9375 30.4 30 4 heterochrony 2.74277718554421e-05 0.000414751261339892 1.38489774003026 0.933333333333333 30.4 30 4 lysosomal protein accumulation 6.38136354151361e-05 0.000869788592302197 1.37783193523419 0.928571428571429 30.4 30 4 multiple persisting craniopharyngeal ducts 6.38136354151361e-05 0.000869788592302197 1.37783193523419 0.928571428571429 30.4 30 4 abnormal vitelline vein topology 6.38136354151361e-05 0.000869788592302197 1.37783193523419 0.928571428571429 30.4 30 4 impaired embryo implantation 0.000340353488728186 0.00354238202180486 1.36016742324401 0.916666666666667 30.4 30 4 abnormal fatty acid level 0.000340353488728186 0.00354238202180486 1.36016742324401 0.916666666666667 30.4 30 4 intestinal inflammation 1.09246170859511e-06 2.45927466075143e-05 1.34892637015935 0.909090909090909 30.4 30 4 abnormal proximal-distal axis patterning 0.00077899280307769 0.00685927291205577 1.34892637015935 0.909090909090909 30.4 30 4 loss of cortex neurons 0.00077899280307769 0.00685927291205577 1.34892637015935 0.909090909090909 30.4 30 4 abnormal radial glial cell morphology 0.00077899280307769 0.00685927291205577 1.34892637015935 0.909090909090909 30.4 30 4 abnormal palate development 0.00077899280307769 0.00685927291205577 1.34892637015935 0.909090909090909 30.4 30 4 reduced sympathetic cervical ganglion size 0.00077899280307769 0.00685927291205577 1.34892637015935 0.909090909090909 30.4 30 4 increased skin tumor incidence 5.58927609210528e-06 0.000106538883364842 1.33543710645775 0.9 30.4 30 4 fused cornea and lens 0.00176977967840886 0.0132202010511773 1.33543710645775 0.9 30.4 30 4 acrania 0.00176977967840886 0.0132202010511773 1.33543710645775 0.9 30.4 30 4 bifid ureter 0.00176977967840886 0.0132202010511773 1.33543710645775 0.9 30.4 30 4 absent seminal vesicle 0.00176977967840886 0.0132202010511773 1.33543710645775 0.9 30.4 30 4 abnormal embryonic erythrocyte morphology 0.00176977967840886 0.0132202010511773 1.33543710645775 0.9 30.4 30 4 abnormal respiratory conducting tube morphology 0.00176977967840886 0.0132202010511773 1.33543710645775 0.9 30.4 30 4 decreased transitional stage T2 B cell number 0.00176977967840886 0.0132202010511773 1.33543710645775 0.9 30.4 30 4 abnormal vibrissa follicle morphology 0.00176977967840886 0.0132202010511773 1.33543710645775 0.9 30.4 30 4 thin ventricle myocardium compact layer 0.00176977967840886 0.0132202010511773 1.33543710645775 0.9 30.4 30 4 thick aortic valve cusps 0.00176977967840886 0.0132202010511773 1.33543710645775 0.9 30.4 30 4 fusion of atlas and odontoid process 0.00176977967840886 0.0132202010511773 1.33543710645775 0.9 30.4 30 4 lethality during fetal growth through weaning, complete penetrance 0.00176977967840886 0.0132202010511773 1.33543710645775 0.9 30.4 30 4 heart hyperplasia 0.00398526623379224 0.0252891575422403 1.31895022860025 0.888888888888889 30.4 30 4 distorted hair follicle pattern 0.00398526623379224 0.0252891575422403 1.31895022860025 0.888888888888889 30.4 30 4 decreased level of surface class I molecules 0.00398526623379224 0.0252891575422403 1.31895022860025 0.888888888888889 30.4 30 4 premature bone ossification 0.00398526623379224 0.0252891575422403 1.31895022860025 0.888888888888889 30.4 30 4 increased neuronal precursor cell number 0.00398526623379224 0.0252891575422403 1.31895022860025 0.888888888888889 30.4 30 4 liver hyperplasia 0.00398526623379224 0.0252891575422403 1.31895022860025 0.888888888888889 30.4 30 4 positive geotaxis 0.00398526623379224 0.0252891575422403 1.31895022860025 0.888888888888889 30.4 30 4 decreased transitional stage T1 B cell number 0.00398526623379224 0.0252891575422403 1.31895022860025 0.888888888888889 30.4 30 4 decreased effector memory CD4-positive, alpha-beta T cell number 0.00398526623379224 0.0252891575422403 1.31895022860025 0.888888888888889 30.4 30 4 abnormal lung lobe morphology 0.00398526623379224 0.0252891575422403 1.31895022860025 0.888888888888889 30.4 30 4 abnormal ductus venosus valve topology 0.00398526623379224 0.0252891575422403 1.31895022860025 0.888888888888889 30.4 30 4 symmetric azygos veins 0.00398526623379224 0.0252891575422403 1.31895022860025 0.888888888888889 30.4 30 4 increased cardiac muscle glycogen level 0.00398526623379224 0.0252891575422403 1.31895022860025 0.888888888888889 30.4 30 4 decreased fatty acid oxidation 0.00398526623379224 0.0252891575422403 1.31895022860025 0.888888888888889 30.4 30 4 cerebellum atrophy 0.00398526623379224 0.0252891575422403 1.31895022860025 0.888888888888889 30.4 30 4 abnormal embryonic epiblast morphology 4.02912238039448e-09 1.57833731043012e-07 1.31423969206954 0.885714285714286 30.4 30 4 abnormal adipose tissue morphology 6.22393865511591e-05 0.000855361735060819 1.30925206515466 0.882352941176471 30.4 30 4 abnormal interatrial septum morphology 6.22393865511591e-05 0.000855361735060819 1.30925206515466 0.882352941176471 30.4 30 4 coloboma 6.22393865511591e-05 0.000855361735060819 1.30925206515466 0.882352941176471 30.4 30 4 abnormal cell differentiation 3.65081580832683e-10 1.78066751435549e-08 1.30286546971488 0.878048780487805 30.4 30 4 disorganized yolk sac vascular plexus 0.00013724045615873 0.00168170263396473 1.29834163127837 0.875 30.4 30 4 sepsis 0.00013724045615873 0.00168170263396473 1.29834163127837 0.875 30.4 30 4 abnormal bone marrow development 0.00887791400242637 0.046590318736362 1.29834163127837 0.875 30.4 30 4 dermal cysts 0.00887791400242637 0.046590318736362 1.29834163127837 0.875 30.4 30 4 absent eyelids 0.00887791400242637 0.046590318736362 1.29834163127837 0.875 30.4 30 4 abnormal hepatobiliary system morphology 0.00887791400242637 0.046590318736362 1.29834163127837 0.875 30.4 30 4 abnormal thyroid physiology 0.00887791400242637 0.046590318736362 1.29834163127837 0.875 30.4 30 4 hypospadia 0.00887791400242637 0.046590318736362 1.29834163127837 0.875 30.4 30 4 lymph node inflammation 0.00887791400242637 0.046590318736362 1.29834163127837 0.875 30.4 30 4 absent interparietal bone 0.00887791400242637 0.046590318736362 1.29834163127837 0.875 30.4 30 4 absent cochlear microphonics 0.00887791400242637 0.046590318736362 1.29834163127837 0.875 30.4 30 4 abnormal kidney epithelium morphology 0.00887791400242637 0.046590318736362 1.29834163127837 0.875 30.4 30 4 abnormal NK cell morphology 0.00887791400242637 0.046590318736362 1.29834163127837 0.875 30.4 30 4 abnormal somite size 0.00887791400242637 0.046590318736362 1.29834163127837 0.875 30.4 30 4 craniofacial phenotype 0.00887791400242637 0.046590318736362 1.29834163127837 0.875 30.4 30 4 abnormal olfactory bulb mitral cell layer morphology 0.00887791400242637 0.046590318736362 1.29834163127837 0.875 30.4 30 4 abnormal cerebellum deep nucleus morphology 0.00887791400242637 0.046590318736362 1.29834163127837 0.875 30.4 30 4 abnormal circulating serum amyloid protein level 0.00887791400242637 0.046590318736362 1.29834163127837 0.875 30.4 30 4 pleural effusion 0.00887791400242637 0.046590318736362 1.29834163127837 0.875 30.4 30 4 pulmonary artery hypoplasia 0.00887791400242637 0.046590318736362 1.29834163127837 0.875 30.4 30 4 absent ureteric bud 0.00887791400242637 0.046590318736362 1.29834163127837 0.875 30.4 30 4 decreased cranium length 0.00887791400242637 0.046590318736362 1.29834163127837 0.875 30.4 30 4 prolonged PQ interval 0.00887791400242637 0.046590318736362 1.29834163127837 0.875 30.4 30 4 retropleural edema 0.00887791400242637 0.046590318736362 1.29834163127837 0.875 30.4 30 4 abnormal umbilical vein topology 0.00887791400242637 0.046590318736362 1.29834163127837 0.875 30.4 30 4 decreased white adipose tissue mass 0.00887791400242637 0.046590318736362 1.29834163127837 0.875 30.4 30 4 decreased thymocyte apoptosis 0.000300321748553147 0.00319935909861222 1.28597647288524 0.866666666666667 30.4 30 4 increased skin papilloma incidence 1.12427506321852e-05 0.000193538700329139 1.28148005165138 0.863636363636364 30.4 30 4 subcutaneous edema 9.48757211126356e-07 2.18521626173779e-05 1.2718448632931 0.857142857142857 30.4 30 4 abnormal embryonic/fetal subventricular zone morphology 2.42653805465925e-05 0.000374545812957682 1.2718448632931 0.857142857142857 30.4 30 4 absent segment of posterior cerebral artery 2.42653805465925e-05 0.000374545812957682 1.2718448632931 0.857142857142857 30.4 30 4 abnormal blood flow velocity 0.000651530923742113 0.00604068796431583 1.2718448632931 0.857142857142857 30.4 30 4 increased hemangioma incidence 0.000651530923742113 0.00604068796431583 1.2718448632931 0.857142857142857 30.4 30 4 abnormal vascular endothelial cell migration 0.000651530923742113 0.00604068796431583 1.2718448632931 0.857142857142857 30.4 30 4 testis degeneration 0.000651530923742113 0.00604068796431583 1.2718448632931 0.857142857142857 30.4 30 4 mammary gland hyperplasia 0.0195134737376937 0.0850083466243664 1.2718448632931 0.857142857142857 30.4 30 4 skin photosensitivity 0.0195134737376937 0.0850083466243664 1.2718448632931 0.857142857142857 30.4 30 4 absent epidermis stratum corneum 0.0195134737376937 0.0850083466243664 1.2718448632931 0.857142857142857 30.4 30 4 retina hyperplasia 0.0195134737376937 0.0850083466243664 1.2718448632931 0.857142857142857 30.4 30 4 abnormal circulating alanine transaminase level 0.0195134737376937 0.0850083466243664 1.2718448632931 0.857142857142857 30.4 30 4 decreased activated T cell number 0.0195134737376937 0.0850083466243664 1.2718448632931 0.857142857142857 30.4 30 4 abnormal hypersensitivity reaction 0.0195134737376937 0.0850083466243664 1.2718448632931 0.857142857142857 30.4 30 4 abnormal gastrulation movements 0.0195134737376937 0.0850083466243664 1.2718448632931 0.857142857142857 30.4 30 4 abnormal brain ventricular system morphology 0.0195134737376937 0.0850083466243664 1.2718448632931 0.857142857142857 30.4 30 4 decreased mortality induced by ionizing radiation 0.0195134737376937 0.0850083466243664 1.2718448632931 0.857142857142857 30.4 30 4 decreased cardiomyocyte apoptosis 0.0195134737376937 0.0850083466243664 1.2718448632931 0.857142857142857 30.4 30 4 abnormal Purkinje cell innervation 0.0195134737376937 0.0850083466243664 1.2718448632931 0.857142857142857 30.4 30 4 increased ectoderm apoptosis 0.0195134737376937 0.0850083466243664 1.2718448632931 0.857142857142857 30.4 30 4 abnormal cochlear nerve compound action potential 0.0195134737376937 0.0850083466243664 1.2718448632931 0.857142857142857 30.4 30 4 abnormal negative T cell selection 0.0195134737376937 0.0850083466243664 1.2718448632931 0.857142857142857 30.4 30 4 abnormal thyroid hormone level 0.0195134737376937 0.0850083466243664 1.2718448632931 0.857142857142857 30.4 30 4 increased keratinocyte apoptosis 0.0195134737376937 0.0850083466243664 1.2718448632931 0.857142857142857 30.4 30 4 abnormal spinal cord central canal morphology 0.0195134737376937 0.0850083466243664 1.2718448632931 0.857142857142857 30.4 30 4 abnormal retina inner limiting membrane morphology 0.0195134737376937 0.0850083466243664 1.2718448632931 0.857142857142857 30.4 30 4 abnormal T wave 0.0195134737376937 0.0850083466243664 1.2718448632931 0.857142857142857 30.4 30 4 heart block 0.0195134737376937 0.0850083466243664 1.2718448632931 0.857142857142857 30.4 30 4 small lung lobe 0.0195134737376937 0.0850083466243664 1.2718448632931 0.857142857142857 30.4 30 4 absent heart tube 0.0195134737376937 0.0850083466243664 1.2718448632931 0.857142857142857 30.4 30 4 absent connection between subcutaneous lymph vessels and lymph sac 0.0195134737376937 0.0850083466243664 1.2718448632931 0.857142857142857 30.4 30 4 decreased collagen level 0.0195134737376937 0.0850083466243664 1.2718448632931 0.857142857142857 30.4 30 4 abnormal brown adipose tissue morphology 8.15639724631353e-08 2.35919048258197e-06 1.26561032964951 0.852941176470588 30.4 30 4 failure to gastrulate 6.23846385919631e-10 2.87373682402793e-08 1.25802046260513 0.847826086956522 30.4 30 4 ventricular hypoplasia 4.32331410589675e-06 8.50137852839381e-05 1.25553915991755 0.846153846153846 30.4 30 4 increased foot pad pigmentation 0.00139954481255019 0.0111582298757007 1.25553915991755 0.846153846153846 30.4 30 4 abnormal grip strength 0.00139954481255019 0.0111582298757007 1.25553915991755 0.846153846153846 30.4 30 4 abnormal bile duct development 0.00139954481255019 0.0111582298757007 1.25553915991755 0.846153846153846 30.4 30 4 abnormal telomere length 0.00139954481255019 0.0111582298757007 1.25553915991755 0.846153846153846 30.4 30 4 tracheoesophageal fistula 0.00139954481255019 0.0111582298757007 1.25553915991755 0.846153846153846 30.4 30 4 increased cochlear inner hair cell number 0.00139954481255019 0.0111582298757007 1.25553915991755 0.846153846153846 30.4 30 4 increased circulating thyroxine level 0.00139954481255019 0.0111582298757007 1.25553915991755 0.846153846153846 30.4 30 4 absent hypoglossal nerve 0.00139954481255019 0.0111582298757007 1.25553915991755 0.846153846153846 30.4 30 4 increased liver adenoma incidence 0.000110612899961007 0.00138964438713639 1.24953179551603 0.842105263157895 30.4 30 4 abnormal interventricular septum morphology 2.45132576087242e-10 1.25725212993199e-08 1.24640796602724 0.84 30.4 30 4 abnormal erythropoiesis 4.40980067114223e-20 1.09693791694663e-17 1.24358164410881 0.838095238095238 30.4 30 4 abnormal optic cup morphology 1.6259079742378e-06 3.47162754155924e-05 1.23651583931273 0.833333333333333 30.4 30 4 abnormal thymus cortex morphology 0.000233259609448465 0.00261366341668044 1.23651583931273 0.833333333333333 30.4 30 4 abnormal bile duct morphology 0.000233259609448465 0.00261366341668044 1.23651583931273 0.833333333333333 30.4 30 4 absent inner cell mass 0.000233259609448465 0.00261366341668044 1.23651583931273 0.833333333333333 30.4 30 4 small thoracic cage 0.000233259609448465 0.00261366341668044 1.23651583931273 0.833333333333333 30.4 30 4 abnormal hypoglossal nerve topology 0.000233259609448465 0.00261366341668044 1.23651583931273 0.833333333333333 30.4 30 4 abnormal truncus arteriosus septation 1.92104177004884e-05 0.000304368879171751 1.23651583931273 0.833333333333333 30.4 30 4 abnormal embryonic growth/weight/body size 0.00297218937482519 0.0201178804622522 1.23651583931273 0.833333333333333 30.4 30 4 decreased synaptic depression 0.00297218937482519 0.0201178804622522 1.23651583931273 0.833333333333333 30.4 30 4 loss of dopaminergic neurons 0.00297218937482519 0.0201178804622522 1.23651583931273 0.833333333333333 30.4 30 4 dilated bile duct 0.00297218937482519 0.0201178804622522 1.23651583931273 0.833333333333333 30.4 30 4 small intestinal inflammation 0.00297218937482519 0.0201178804622522 1.23651583931273 0.833333333333333 30.4 30 4 absent ovary 0.00297218937482519 0.0201178804622522 1.23651583931273 0.833333333333333 30.4 30 4 increased osteosarcoma incidence 0.00297218937482519 0.0201178804622522 1.23651583931273 0.833333333333333 30.4 30 4 abnormal defecation 0.00297218937482519 0.0201178804622522 1.23651583931273 0.833333333333333 30.4 30 4 pale placenta 0.00297218937482519 0.0201178804622522 1.23651583931273 0.833333333333333 30.4 30 4 persistent right dorsal aorta 0.00297218937482519 0.0201178804622522 1.23651583931273 0.833333333333333 30.4 30 4 prenatal growth retardation 0.00297218937482519 0.0201178804622522 1.23651583931273 0.833333333333333 30.4 30 4 abnormal vitelline vein connection 0.00297218937482519 0.0201178804622522 1.23651583931273 0.833333333333333 30.4 30 4 absent limbs 0.042160068177915 0.147293777517645 1.23651583931273 0.833333333333333 30.4 30 4 thin tail 0.042160068177915 0.147293777517645 1.23651583931273 0.833333333333333 30.4 30 4 absent superior cervical ganglion 0.042160068177915 0.147293777517645 1.23651583931273 0.833333333333333 30.4 30 4 delayed brain development 0.042160068177915 0.147293777517645 1.23651583931273 0.833333333333333 30.4 30 4 abnormal blood gas level 0.042160068177915 0.147293777517645 1.23651583931273 0.833333333333333 30.4 30 4 abnormal lymph node cortex morphology 0.042160068177915 0.147293777517645 1.23651583931273 0.833333333333333 30.4 30 4 chromatolysis 0.042160068177915 0.147293777517645 1.23651583931273 0.833333333333333 30.4 30 4 abnormal sebaceous lipid secretion 0.042160068177915 0.147293777517645 1.23651583931273 0.833333333333333 30.4 30 4 abnormal hippocampal fimbria morphology 0.042160068177915 0.147293777517645 1.23651583931273 0.833333333333333 30.4 30 4 phenotypic reversion 0.042160068177915 0.147293777517645 1.23651583931273 0.833333333333333 30.4 30 4 esophageal atresia 0.042160068177915 0.147293777517645 1.23651583931273 0.833333333333333 30.4 30 4 pancreas fibrosis 0.042160068177915 0.147293777517645 1.23651583931273 0.833333333333333 30.4 30 4 abnormal cholesterol level 0.042160068177915 0.147293777517645 1.23651583931273 0.833333333333333 30.4 30 4 abnormal physical strength 0.042160068177915 0.147293777517645 1.23651583931273 0.833333333333333 30.4 30 4 vestibular saccular degeneration 0.042160068177915 0.147293777517645 1.23651583931273 0.833333333333333 30.4 30 4 abnormal common crus morphology 0.042160068177915 0.147293777517645 1.23651583931273 0.833333333333333 30.4 30 4 decreased prostate gland weight 0.042160068177915 0.147293777517645 1.23651583931273 0.833333333333333 30.4 30 4 impaired granulocyte bactericidal activity 0.042160068177915 0.147293777517645 1.23651583931273 0.833333333333333 30.4 30 4 osteomyelitis 0.042160068177915 0.147293777517645 1.23651583931273 0.833333333333333 30.4 30 4 abnormal adipose tissue amount 0.042160068177915 0.147293777517645 1.23651583931273 0.833333333333333 30.4 30 4 abnormal dermis papillary layer morphology 0.042160068177915 0.147293777517645 1.23651583931273 0.833333333333333 30.4 30 4 delayed chorioallantoic fusion 0.042160068177915 0.147293777517645 1.23651583931273 0.833333333333333 30.4 30 4 absent sperm mitochondrial sheath 0.042160068177915 0.147293777517645 1.23651583931273 0.833333333333333 30.4 30 4 abnormal neural crest cell morphology 0.042160068177915 0.147293777517645 1.23651583931273 0.833333333333333 30.4 30 4 exostosis 0.042160068177915 0.147293777517645 1.23651583931273 0.833333333333333 30.4 30 4 abnormal olfactory bulb layer morphology 0.042160068177915 0.147293777517645 1.23651583931273 0.833333333333333 30.4 30 4 abnormal orbit morphology 0.042160068177915 0.147293777517645 1.23651583931273 0.833333333333333 30.4 30 4 enlarged lymphatic vessel 0.042160068177915 0.147293777517645 1.23651583931273 0.833333333333333 30.4 30 4 myocardium hypoplasia 0.042160068177915 0.147293777517645 1.23651583931273 0.833333333333333 30.4 30 4 cerebral arteriovenous malformation 0.042160068177915 0.147293777517645 1.23651583931273 0.833333333333333 30.4 30 4 thick pulmonary valve cusps 0.042160068177915 0.147293777517645 1.23651583931273 0.833333333333333 30.4 30 4 persistent hyperplastic primary vitreous 0.042160068177915 0.147293777517645 1.23651583931273 0.833333333333333 30.4 30 4 absent alveolar lamellar bodies 0.042160068177915 0.147293777517645 1.23651583931273 0.833333333333333 30.4 30 4 ectopic ureteric bud 0.042160068177915 0.147293777517645 1.23651583931273 0.833333333333333 30.4 30 4 abnormal ureteric bud tip morphology 0.042160068177915 0.147293777517645 1.23651583931273 0.833333333333333 30.4 30 4 abnormal kidney collecting duct epithelium morphology 0.042160068177915 0.147293777517645 1.23651583931273 0.833333333333333 30.4 30 4 increased total retina thickness 0.042160068177915 0.147293777517645 1.23651583931273 0.833333333333333 30.4 30 4 abnormal Rathke's pouch development 0.042160068177915 0.147293777517645 1.23651583931273 0.833333333333333 30.4 30 4 increased CD11b-high dendritic cell number 0.042160068177915 0.147293777517645 1.23651583931273 0.833333333333333 30.4 30 4 ciliary body hypoplasia 0.042160068177915 0.147293777517645 1.23651583931273 0.833333333333333 30.4 30 4 abnormal Wolffian duct connection 0.042160068177915 0.147293777517645 1.23651583931273 0.833333333333333 30.4 30 4 decreased hippocampus volume 0.042160068177915 0.147293777517645 1.23651583931273 0.833333333333333 30.4 30 4 blood in lymph vessels 3.38710064183971e-06 6.79468777949699e-05 1.2279881438692 0.827586206896552 30.4 30 4 abnormal vertebral artery topology 4.00598616043649e-05 0.000587899148913614 1.22576352766654 0.826086956521739 30.4 30 4 abnormal direction of heart looping 6.03640119826969e-07 1.45077758267593e-05 1.22196859414435 0.823529411764706 30.4 30 4 small superior cervical ganglion 7.0103698937417e-06 0.000130136530676735 1.21885132732255 0.821428571428571 30.4 30 4 abnormal neural tube closure 7.892274766257e-15 8.72534821380635e-13 1.21565894563758 0.819277108433735 30.4 30 4 abnormal enterocyte morphology 8.28672151614259e-05 0.00107081661150154 1.21403373314341 0.818181818181818 30.4 30 4 abnormal germ layer development 8.28672151614259e-05 0.00107081661150154 1.21403373314341 0.818181818181818 30.4 30 4 aphakia 8.28672151614259e-05 0.00107081661150154 1.21403373314341 0.818181818181818 30.4 30 4 embryonic lethality before implantation, incomplete penetrance 8.28672151614259e-05 0.00107081661150154 1.21403373314341 0.818181818181818 30.4 30 4 abnormal sphenoid bone morphology 0.00622832061739912 0.0350123108153227 1.21403373314341 0.818181818181818 30.4 30 4 decreased atrioventricular cushion size 0.00622832061739912 0.0350123108153227 1.21403373314341 0.818181818181818 30.4 30 4 delayed hepatic development 0.00622832061739912 0.0350123108153227 1.21403373314341 0.818181818181818 30.4 30 4 abnormal eye distance/ position 0.00622832061739912 0.0350123108153227 1.21403373314341 0.818181818181818 30.4 30 4 secondary sex reversal 0.00622832061739912 0.0350123108153227 1.21403373314341 0.818181818181818 30.4 30 4 fatigue 0.00622832061739912 0.0350123108153227 1.21403373314341 0.818181818181818 30.4 30 4 fused joints 0.00622832061739912 0.0350123108153227 1.21403373314341 0.818181818181818 30.4 30 4 dilated renal glomerular capsule 0.00622832061739912 0.0350123108153227 1.21403373314341 0.818181818181818 30.4 30 4 abnormal pituitary gland development 0.00622832061739912 0.0350123108153227 1.21403373314341 0.818181818181818 30.4 30 4 abnormal palatal shelf elevation 0.00622832061739912 0.0350123108153227 1.21403373314341 0.818181818181818 30.4 30 4 aorta dilation 0.00622832061739912 0.0350123108153227 1.21403373314341 0.818181818181818 30.4 30 4 common atrioventricular valve 0.00622832061739912 0.0350123108153227 1.21403373314341 0.818181818181818 30.4 30 4 abnormal pulmonary alveolar sac morphology 0.00622832061739912 0.0350123108153227 1.21403373314341 0.818181818181818 30.4 30 4 decreased neuron apoptosis 2.22341845434067e-07 5.91524428360687e-06 1.21048392690615 0.815789473684211 30.4 30 4 abnormal eye muscle morphology 1.44086687636889e-05 0.000238149923918113 1.20903770955023 0.814814814814815 30.4 30 4 increased fibroblast apoptosis 2.54254338502306e-06 5.22692286797096e-05 1.20560294332992 0.8125 30.4 30 4 abnormal epicardium morphology 0.00100700734892895 0.00847692311492647 1.20560294332992 0.8125 30.4 30 4 increased thymus weight 0.00100700734892895 0.00847692311492647 1.20560294332992 0.8125 30.4 30 4 dystonia 0.00100700734892895 0.00847692311492647 1.20560294332992 0.8125 30.4 30 4 abnormal hematopoietic system physiology 0.000169912913641432 0.00202713847809622 1.20118681533237 0.80952380952381 30.4 30 4 left pulmonary isomerism 0.000169912913641432 0.00202713847809622 1.20118681533237 0.80952380952381 30.4 30 4 liver hypoplasia 2.67619578777669e-09 1.08244504424301e-07 1.19846919810311 0.807692307692308 30.4 30 4 abnormal Mullerian duct morphology 2.9392856687831e-05 0.00044045018681313 1.19846919810311 0.807692307692308 30.4 30 4 inner cell mass degeneration 5.16814271048682e-06 9.96570154444649e-05 1.19662823159297 0.806451612903226 30.4 30 4 abnormal lysosome morphology 9.19171825293627e-07 2.12692085155153e-05 1.19529864466898 0.805555555555556 30.4 30 4 embryonic lethality between implantation and placentation, complete penetrance 2.97608438637426e-08 9.67713713870061e-07 1.19350659272794 0.804347826086957 30.4 30 4 small lung 5.3995949174872e-09 2.06638343957683e-07 1.19287410380758 0.803921568627451 30.4 30 4 abnormal cochlear outer hair cell morphology 5.947456855429e-05 0.000827372793201436 1.18705520574023 0.8 30.4 30 4 abnormal lens epithelium morphology 0.000345033428594027 0.00355391575001094 1.18705520574023 0.8 30.4 30 4 absent placental labyrinth 0.000345033428594027 0.00355391575001094 1.18705520574023 0.8 30.4 30 4 abnormal epidermis stratum spinosum morphology 0.00205636762449799 0.0149794691193543 1.18705520574023 0.8 30.4 30 4 abnormal bronchus morphology 0.00205636762449799 0.0149794691193543 1.18705520574023 0.8 30.4 30 4 delayed intramembranous bone ossification 0.00205636762449799 0.0149794691193543 1.18705520574023 0.8 30.4 30 4 abnormal trophectoderm morphology 0.00205636762449799 0.0149794691193543 1.18705520574023 0.8 30.4 30 4 immune system phenotype 0.00205636762449799 0.0149794691193543 1.18705520574023 0.8 30.4 30 4 abnormal branching involved in lung morphogenesis 0.00205636762449799 0.0149794691193543 1.18705520574023 0.8 30.4 30 4 abnormal auchene hair morphology 0.0128472124553258 0.0611625664739193 1.18705520574023 0.8 30.4 30 4 retarded hair growth 0.0128472124553258 0.0611625664739193 1.18705520574023 0.8 30.4 30 4 jaundice 0.0128472124553258 0.0611625664739193 1.18705520574023 0.8 30.4 30 4 increased atrioventricular cushion size 0.0128472124553258 0.0611625664739193 1.18705520574023 0.8 30.4 30 4 abnormal hindlimb zeugopod morphology 0.0128472124553258 0.0611625664739193 1.18705520574023 0.8 30.4 30 4 increased heart rate variability 0.0128472124553258 0.0611625664739193 1.18705520574023 0.8 30.4 30 4 abnormal reproductive system development 0.0128472124553258 0.0611625664739193 1.18705520574023 0.8 30.4 30 4 abnormal gonadal fat pad morphology 0.0128472124553258 0.0611625664739193 1.18705520574023 0.8 30.4 30 4 tachypnea 0.0128472124553258 0.0611625664739193 1.18705520574023 0.8 30.4 30 4 increased platelet aggregation 0.0128472124553258 0.0611625664739193 1.18705520574023 0.8 30.4 30 4 crystalluria 0.0128472124553258 0.0611625664739193 1.18705520574023 0.8 30.4 30 4 acanthocytosis 0.0128472124553258 0.0611625664739193 1.18705520574023 0.8 30.4 30 4 abnormal adaptive thermogenesis 0.0128472124553258 0.0611625664739193 1.18705520574023 0.8 30.4 30 4 decreased macrophage cytokine production 0.0128472124553258 0.0611625664739193 1.18705520574023 0.8 30.4 30 4 decreased macrophage apoptosis 0.0128472124553258 0.0611625664739193 1.18705520574023 0.8 30.4 30 4 increased hepatocyte apoptosis 6.63711189424587e-07 1.57988668296044e-05 1.1794458774983 0.794871794871795 30.4 30 4 decreased trophoblast giant cell number 2.08995686926993e-05 0.0003279979629217 1.17682197120798 0.793103448275862 30.4 30 4 ocular hypertelorism 0.000119287748439096 0.00147994151741772 1.1746900473471 0.791666666666667 30.4 30 4 increased susceptibility to ischemic brain injury 0.000693184770026428 0.00621368329888555 1.17143605829628 0.789473684210526 30.4 30 4 absent amnion 0.000693184770026428 0.00621368329888555 1.17143605829628 0.789473684210526 30.4 30 4 decreased liver regeneration 0.000693184770026428 0.00621368329888555 1.17143605829628 0.789473684210526 30.4 30 4 increased liver cholesterol level 0.000693184770026428 0.00621368329888555 1.17143605829628 0.789473684210526 30.4 30 4 embryonic lethality between implantation and somite formation, incomplete penetrance 0.000693184770026428 0.00621368329888555 1.17143605829628 0.789473684210526 30.4 30 4 straub tail 4.15357646201619e-05 0.000604211780658788 1.16585779135201 0.785714285714286 30.4 30 4 premature aging 4.15357646201619e-05 0.000604211780658788 1.16585779135201 0.785714285714286 30.4 30 4 abnormal brainstem morphology 4.15357646201619e-05 0.000604211780658788 1.16585779135201 0.785714285714286 30.4 30 4 midline facial cleft 0.0041422624048465 0.0260527881973594 1.16585779135201 0.785714285714286 30.4 30 4 increased aggression towards males 0.0041422624048465 0.0260527881973594 1.16585779135201 0.785714285714286 30.4 30 4 premature hair loss 0.0041422624048465 0.0260527881973594 1.16585779135201 0.785714285714286 30.4 30 4 abnormal viscerocranium morphology 0.0041422624048465 0.0260527881973594 1.16585779135201 0.785714285714286 30.4 30 4 spina bifida occulta 0.0041422624048465 0.0260527881973594 1.16585779135201 0.785714285714286 30.4 30 4 abnormal chromosome morphology 2.60764206338277e-06 5.33869105569106e-05 1.16299327589414 0.783783783783784 30.4 30 4 increased erythrocyte cell number 2.02243797511666e-09 8.38469077183783e-08 1.16232488895397 0.783333333333333 30.4 30 4 abnormal cardiovascular development 0.000236973687966845 0.0026433724162221 1.16124965778935 0.782608695652174 30.4 30 4 abnormal Wolffian duct morphology 0.000236973687966845 0.0026433724162221 1.16124965778935 0.782608695652174 30.4 30 4 decreased circulating total protein level 1.10116238048993e-08 4.05798729106475e-07 1.16007667833704 0.781818181818182 30.4 30 4 increased fatty acid level 1.45452831585715e-05 0.000239611866602295 1.15923359935569 0.78125 30.4 30 4 abnormal apoptosis 2.15215938990065e-08 7.29689005960583e-07 1.15408145002522 0.777777777777778 30.4 30 4 abnormal trophoblast giant cell morphology 5.11718205481418e-06 9.90582907498076e-05 1.15408145002522 0.777777777777778 30.4 30 4 abnormal atrioventricular cushion morphology 8.18375144223283e-05 0.00106861321325744 1.15408145002522 0.777777777777778 30.4 30 4 abnormal type II pneumocyte morphology 8.18375144223283e-05 0.00106861321325744 1.15408145002522 0.777777777777778 30.4 30 4 abnormal mitral valve morphology 0.00137619588140365 0.0111326414796474 1.15408145002522 0.777777777777778 30.4 30 4 absent allantois 0.00137619588140365 0.0111326414796474 1.15408145002522 0.777777777777778 30.4 30 4 abnormal eye anterior chamber morphology 0.00137619588140365 0.0111326414796474 1.15408145002522 0.777777777777778 30.4 30 4 decreased tumor latency 0.00137619588140365 0.0111326414796474 1.15408145002522 0.777777777777778 30.4 30 4 atrioventricular block 0.00137619588140365 0.0111326414796474 1.15408145002522 0.777777777777778 30.4 30 4 increased effector memory CD8-positive, alpha-beta T cell number 0.00137619588140365 0.0111326414796474 1.15408145002522 0.777777777777778 30.4 30 4 increased adipocyte glucose uptake 0.00137619588140365 0.0111326414796474 1.15408145002522 0.777777777777778 30.4 30 4 renal tubular acidosis 0.0260021811926458 0.101615122081211 1.15408145002522 0.777777777777778 30.4 30 4 abnormal sympathetic neuron morphology 0.0260021811926458 0.101615122081211 1.15408145002522 0.777777777777778 30.4 30 4 abnormal geniculate ganglion morphology 0.0260021811926458 0.101615122081211 1.15408145002522 0.777777777777778 30.4 30 4 abnormal germ cell morphology 0.0260021811926458 0.101615122081211 1.15408145002522 0.777777777777778 30.4 30 4 abnormal lens capsule morphology 0.0260021811926458 0.101615122081211 1.15408145002522 0.777777777777778 30.4 30 4 biliary cyst 0.0260021811926458 0.101615122081211 1.15408145002522 0.777777777777778 30.4 30 4 abnormal thymus physiology 0.0260021811926458 0.101615122081211 1.15408145002522 0.777777777777778 30.4 30 4 decreased cellular sensitivity to ionizing radiation 0.0260021811926458 0.101615122081211 1.15408145002522 0.777777777777778 30.4 30 4 decreased cochlear hair cell number 0.0260021811926458 0.101615122081211 1.15408145002522 0.777777777777778 30.4 30 4 abnormal posterior eye segment morphology 0.0260021811926458 0.101615122081211 1.15408145002522 0.777777777777778 30.4 30 4 abnormal inguinal fat pad morphology 0.0260021811926458 0.101615122081211 1.15408145002522 0.777777777777778 30.4 30 4 abnormal cerebellar layer morphology 0.0260021811926458 0.101615122081211 1.15408145002522 0.777777777777778 30.4 30 4 prolonged RR interval 0.0260021811926458 0.101615122081211 1.15408145002522 0.777777777777778 30.4 30 4 iris coloboma 0.0260021811926458 0.101615122081211 1.15408145002522 0.777777777777778 30.4 30 4 fusion of atlas and occipital bones 0.0260021811926458 0.101615122081211 1.15408145002522 0.777777777777778 30.4 30 4 abnormal pulmonary alveolar system morphology 0.0260021811926458 0.101615122081211 1.15408145002522 0.777777777777778 30.4 30 4 increased core body temperature 0.0260021811926458 0.101615122081211 1.15408145002522 0.777777777777778 30.4 30 4 decreased bone trabecular spacing 0.0260021811926458 0.101615122081211 1.15408145002522 0.777777777777778 30.4 30 4 trigeminal neuroma 0.0260021811926458 0.101615122081211 1.15408145002522 0.777777777777778 30.4 30 4 abnormal infrahyoid muscle connection 0.0260021811926458 0.101615122081211 1.15408145002522 0.777777777777778 30.4 30 4 enhanced leukocyte tethering or rolling 0.0260021811926458 0.101615122081211 1.15408145002522 0.777777777777778 30.4 30 4 increased endoplasmic reticulum stress 0.0260021811926458 0.101615122081211 1.15408145002522 0.777777777777778 30.4 30 4 abnormal lung development 2.31107538548042e-12 1.66631884677755e-10 1.1521418173361 0.776470588235294 30.4 30 4 abnormal hepatocyte morphology 1.39501190867292e-15 1.82636427517047e-13 1.14962553709076 0.774774774774775 30.4 30 4 preaxial polydactyly 2.84789408039983e-05 0.000429341607575428 1.14876310232925 0.774193548387097 30.4 30 4 delayed bone ossification 6.66010596423721e-11 3.64110188704177e-09 1.14748669888222 0.773333333333333 30.4 30 4 increased myocardial infarction size 0.000465868288473452 0.00458042437777751 1.14658741463544 0.772727272727273 30.4 30 4 abnormal lysosome physiology 0.000465868288473452 0.00458042437777751 1.14658741463544 0.772727272727273 30.4 30 4 parakeratosis 0.000465868288473452 0.00458042437777751 1.14658741463544 0.772727272727273 30.4 30 4 failure of palatal shelf elevation 0.000465868288473452 0.00458042437777751 1.14658741463544 0.772727272727273 30.4 30 4 increased hepatocellular carcinoma incidence 1.49659837987016e-08 5.39534560858989e-07 1.14540414588969 0.771929824561403 30.4 30 4 embryonic lethality between somite formation and embryo turning, complete penetrance 3.57665393946689e-10 1.76176765830176e-08 1.14466037696379 0.771428571428571 30.4 30 4 increased carcinoma incidence 9.96970806666121e-06 0.000173424117593145 1.14466037696379 0.771428571428571 30.4 30 4 holoprosencephaly 9.96970806666121e-06 0.000173424117593145 1.14466037696379 0.771428571428571 30.4 30 4 decreased glycogen level 9.96970806666121e-06 0.000173424117593145 1.14466037696379 0.771428571428571 30.4 30 4 small liver 4.6339216594855e-11 2.65919600115126e-09 1.14139923628868 0.769230769230769 30.4 30 4 abnormal cornea morphology 4.6339216594855e-11 2.65919600115126e-09 1.14139923628868 0.769230769230769 30.4 30 4 eyelids open at birth 8.0975408536007e-08 2.35586349395693e-06 1.14139923628868 0.769230769230769 30.4 30 4 thick skin 0.000159746941442486 0.00192431243020913 1.14139923628868 0.769230769230769 30.4 30 4 heart inflammation 0.000159746941442486 0.00192431243020913 1.14139923628868 0.769230769230769 30.4 30 4 increased thymocyte apoptosis 0.000159746941442486 0.00192431243020913 1.14139923628868 0.769230769230769 30.4 30 4 absent teeth 0.00821433791574186 0.0448966965453051 1.14139923628868 0.769230769230769 30.4 30 4 pup cannibalization 0.00821433791574186 0.0448966965453051 1.14139923628868 0.769230769230769 30.4 30 4 abnormal pulmonary alveolus epithelial cell morphology 0.00821433791574186 0.0448966965453051 1.14139923628868 0.769230769230769 30.4 30 4 abnormal coping response 0.00821433791574186 0.0448966965453051 1.14139923628868 0.769230769230769 30.4 30 4 axonal dystrophy 0.00821433791574186 0.0448966965453051 1.14139923628868 0.769230769230769 30.4 30 4 abnormal double-strand DNA break repair 1.23829496226164e-06 2.75023099877305e-05 1.1387448194601 0.767441860465116 30.4 30 4 enlarged liver sinusoidal spaces 1.92757020690465e-05 0.000304433707280972 1.13468512313404 0.764705882352941 30.4 30 4 increased incidence of corneal inflammation 0.00269623352805069 0.0187081754561397 1.13468512313404 0.764705882352941 30.4 30 4 hyperlipidemia 0.00269623352805069 0.0187081754561397 1.13468512313404 0.764705882352941 30.4 30 4 abnormal dorsal-ventral axis patterning 0.00269623352805069 0.0187081754561397 1.13468512313404 0.764705882352941 30.4 30 4 abnormal embryonic-extraembryonic boundary morphology 0.00269623352805069 0.0187081754561397 1.13468512313404 0.764705882352941 30.4 30 4 abnormal ectoplacental cone morphology 0.00269623352805069 0.0187081754561397 1.13468512313404 0.764705882352941 30.4 30 4 abnormal tarsal bone morphology 0.00269623352805069 0.0187081754561397 1.13468512313404 0.764705882352941 30.4 30 4 increased brain size 0.00269623352805069 0.0187081754561397 1.13468512313404 0.764705882352941 30.4 30 4 abnormal ductus venosus valve morphology 0.00269623352805069 0.0187081754561397 1.13468512313404 0.764705882352941 30.4 30 4 decreased total retina thickness 6.75733602363223e-06 0.000126382506457031 1.1323881896864 0.763157894736842 30.4 30 4 abnormal eye morphology 5.65567245603167e-18 1.08219117187529e-15 1.13154542993223 0.762589928057554 30.4 30 4 spina bifida 2.37953844736537e-06 4.93258490651779e-05 1.13052876737164 0.761904761904762 30.4 30 4 liver degeneration 0.000905419076442332 0.00783384331356626 1.13052876737164 0.761904761904762 30.4 30 4 abnormal erythrocyte physiology 0.000905419076442332 0.00783384331356626 1.13052876737164 0.761904761904762 30.4 30 4 abnormal tumor vascularization 0.000905419076442332 0.00783384331356626 1.13052876737164 0.761904761904762 30.4 30 4 embryonic lethality at implantation, complete penetrance 0.000905419076442332 0.00783384331356626 1.13052876737164 0.761904761904762 30.4 30 4 corneal opacity 9.06864033636738e-10 3.88935221322653e-08 1.12853839982345 0.76056338028169 30.4 30 4 ruffled hair 0.000308696151407651 0.0032468569836217 1.12770244545321 0.76 30.4 30 4 mandible hypoplasia 0.000308696151407651 0.0032468569836217 1.12770244545321 0.76 30.4 30 4 abnormal egg cylinder morphology 0.000308696151407651 0.0032468569836217 1.12770244545321 0.76 30.4 30 4 abnormal keratinocyte physiology 0.000308696151407651 0.0032468569836217 1.12770244545321 0.76 30.4 30 4 abnormal outer ear morphology 0.000106392380392188 0.00134000529734464 1.12565579854677 0.758620689655172 30.4 30 4 decreased brown adipose tissue amount 3.69660890523222e-05 0.000545716003072115 1.12410530846612 0.757575757575758 30.4 30 4 increased erythroid progenitor cell number 1.2924639805934e-05 0.00021694317826301 1.122890059484 0.756756756756757 30.4 30 4 abnormal respiratory electron transport chain 1.2924639805934e-05 0.00021694317826301 1.122890059484 0.756756756756757 30.4 30 4 trabecula carnea hypoplasia 1.60228563152912e-06 3.46581348559016e-05 1.12110769431021 0.755555555555556 30.4 30 4 increased circulating bilirubin level 2.01348685921089e-07 5.48883786839079e-06 1.11986340164172 0.754716981132076 30.4 30 4 atrioventricular septal defect 2.01348685921089e-07 5.48883786839079e-06 1.11986340164172 0.754716981132076 30.4 30 4 increased double-negative T cell number 2.55461465366879e-08 8.4166939748359e-07 1.1189454808207 0.754098360655738 30.4 30 4 seminiferous tubule degeneration 1.16923980229489e-09 4.97176753539919e-08 1.11794582732384 0.753424657534247 30.4 30 4 anophthalmia 1.94510138759939e-11 1.20960992541337e-09 1.11703228630049 0.752808988764045 30.4 30 4 failure of blastocyst to hatch from the zona pellucida 0.000202742763828828 0.0023402441996483 1.11286425538146 0.75 30.4 30 4 hypoxia 0.000202742763828828 0.0023402441996483 1.11286425538146 0.75 30.4 30 4 abnormal mitotic spindle morphology 0.000202742763828828 0.0023402441996483 1.11286425538146 0.75 30.4 30 4 decreased mean corpuscular hemoglobin 6.15155851889601e-09 2.31848512359906e-07 1.11286425538146 0.75 30.4 30 4 epidermal hyperplasia 4.81924234017711e-08 1.47090372039148e-06 1.11286425538146 0.75 30.4 30 4 muscular ventricular septal defect 4.81924234017711e-08 1.47090372039148e-06 1.11286425538146 0.75 30.4 30 4 vertebral transformation 1.07238512165798e-06 2.4361260183783e-05 1.11286425538146 0.75 30.4 30 4 decreased circulating phosphate level 8.60570168057853e-06 0.000154560887584398 1.11286425538146 0.75 30.4 30 4 failure of primitive streak formation 7.02799137402784e-05 0.000947540842433293 1.11286425538146 0.75 30.4 30 4 abnormal embryonic hematopoiesis 7.02799137402784e-05 0.000947540842433293 1.11286425538146 0.75 30.4 30 4 increased hemangiosarcoma incidence 0.000590031506550089 0.00558998442342585 1.11286425538146 0.75 30.4 30 4 abnormal lung saccule morphology 0.000590031506550089 0.00558998442342585 1.11286425538146 0.75 30.4 30 4 small gonad 0.00173763879432363 0.0132202010511773 1.11286425538146 0.75 30.4 30 4 abnormal circulating enzyme level 0.00173763879432363 0.0132202010511773 1.11286425538146 0.75 30.4 30 4 abnormal physiological neovascularization 0.00173763879432363 0.0132202010511773 1.11286425538146 0.75 30.4 30 4 abnormal optic stalk morphology 0.00173763879432363 0.0132202010511773 1.11286425538146 0.75 30.4 30 4 abnormal neuron proliferation 0.00173763879432363 0.0132202010511773 1.11286425538146 0.75 30.4 30 4 decreased muscle cell glucose uptake 0.00173763879432363 0.0132202010511773 1.11286425538146 0.75 30.4 30 4 decreased mast cell number 0.00520444845120507 0.0312706896675667 1.11286425538146 0.75 30.4 30 4 abnormal hair follicle orientation 0.00520444845120507 0.0312706896675667 1.11286425538146 0.75 30.4 30 4 disorganized retinal layers 0.00520444845120507 0.0312706896675667 1.11286425538146 0.75 30.4 30 4 abnormal pulmonary elastic fiber morphology 0.00520444845120507 0.0312706896675667 1.11286425538146 0.75 30.4 30 4 abnormal level of surface class II molecules 0.00520444845120507 0.0312706896675667 1.11286425538146 0.75 30.4 30 4 decreased circulating triiodothyronine level 0.00520444845120507 0.0312706896675667 1.11286425538146 0.75 30.4 30 4 abnormal pulmonary alveolus wall morphology 0.00520444845120507 0.0312706896675667 1.11286425538146 0.75 30.4 30 4 embryonic lethality between somite formation and embryo turning, incomplete penetrance 0.00520444845120507 0.0312706896675667 1.11286425538146 0.75 30.4 30 4 decreased adipocyte glucose uptake 0.00520444845120507 0.0312706896675667 1.11286425538146 0.75 30.4 30 4 ear inflammation 0.0159967143451209 0.0723487762427058 1.11286425538146 0.75 30.4 30 4 myocarditis 0.0159967143451209 0.0723487762427058 1.11286425538146 0.75 30.4 30 4 altered tumor susceptibility 0.0159967143451209 0.0723487762427058 1.11286425538146 0.75 30.4 30 4 abnormal respiratory function 0.0159967143451209 0.0723487762427058 1.11286425538146 0.75 30.4 30 4 decreased circulating ketone body level 0.0159967143451209 0.0723487762427058 1.11286425538146 0.75 30.4 30 4 abnormal vascular endothelial cell development 0.0159967143451209 0.0723487762427058 1.11286425538146 0.75 30.4 30 4 delayed somite formation 0.0159967143451209 0.0723487762427058 1.11286425538146 0.75 30.4 30 4 vestibular saccular macula degeneration 0.0159967143451209 0.0723487762427058 1.11286425538146 0.75 30.4 30 4 decreased cochlear nerve compound action potential 0.0159967143451209 0.0723487762427058 1.11286425538146 0.75 30.4 30 4 abnormal cochlear outer hair cell physiology 0.0159967143451209 0.0723487762427058 1.11286425538146 0.75 30.4 30 4 abnormal palatine bone morphology 0.0159967143451209 0.0723487762427058 1.11286425538146 0.75 30.4 30 4 decreased keratinocyte proliferation 0.0159967143451209 0.0723487762427058 1.11286425538146 0.75 30.4 30 4 decreased prostaglandin level 0.0159967143451209 0.0723487762427058 1.11286425538146 0.75 30.4 30 4 decreased red blood cell distribution width 0.0159967143451209 0.0723487762427058 1.11286425538146 0.75 30.4 30 4 increased fibrosarcoma incidence 0.0159967143451209 0.0723487762427058 1.11286425538146 0.75 30.4 30 4 abnormal pulmonary valve cusp morphology 0.0159967143451209 0.0723487762427058 1.11286425538146 0.75 30.4 30 4 embryonic lethality between implantation and placentation, incomplete penetrance 0.0159967143451209 0.0723487762427058 1.11286425538146 0.75 30.4 30 4 failure of vascular branching 0.051420152943496 0.174379864276682 1.11286425538146 0.75 30.4 30 4 schistocytosis 0.051420152943496 0.174379864276682 1.11286425538146 0.75 30.4 30 4 abnormal esophageal epithelium morphology 0.051420152943496 0.174379864276682 1.11286425538146 0.75 30.4 30 4 increased sensitivity to skin irradiation 0.051420152943496 0.174379864276682 1.11286425538146 0.75 30.4 30 4 abnormal pupil morphology 0.051420152943496 0.174379864276682 1.11286425538146 0.75 30.4 30 4 spinning 0.051420152943496 0.174379864276682 1.11286425538146 0.75 30.4 30 4 preneoplasia 0.051420152943496 0.174379864276682 1.11286425538146 0.75 30.4 30 4 abnormal secondary sex determination 0.051420152943496 0.174379864276682 1.11286425538146 0.75 30.4 30 4 abnormal pulmonary circulation 0.051420152943496 0.174379864276682 1.11286425538146 0.75 30.4 30 4 abnormal soft palate morphology 0.051420152943496 0.174379864276682 1.11286425538146 0.75 30.4 30 4 abnormal perineum morphology 0.051420152943496 0.174379864276682 1.11286425538146 0.75 30.4 30 4 liver failure 0.051420152943496 0.174379864276682 1.11286425538146 0.75 30.4 30 4 liver cysts 0.051420152943496 0.174379864276682 1.11286425538146 0.75 30.4 30 4 abnormal ovary development 0.051420152943496 0.174379864276682 1.11286425538146 0.75 30.4 30 4 abnormal forelimb zeugopod morphology 0.051420152943496 0.174379864276682 1.11286425538146 0.75 30.4 30 4 long femur 0.051420152943496 0.174379864276682 1.11286425538146 0.75 30.4 30 4 abnormal canal of Schlemm morphology 0.051420152943496 0.174379864276682 1.11286425538146 0.75 30.4 30 4 Sertoli cell hypoplasia 0.051420152943496 0.174379864276682 1.11286425538146 0.75 30.4 30 4 hypergranulosis 0.051420152943496 0.174379864276682 1.11286425538146 0.75 30.4 30 4 abnormal mitotic spindle assembly checkpoint 0.051420152943496 0.174379864276682 1.11286425538146 0.75 30.4 30 4 abnormal olfactory bulb glomerular layer morphology 0.051420152943496 0.174379864276682 1.11286425538146 0.75 30.4 30 4 decreased serotonin level 0.051420152943496 0.174379864276682 1.11286425538146 0.75 30.4 30 4 decreased quadriceps weight 0.051420152943496 0.174379864276682 1.11286425538146 0.75 30.4 30 4 increased heart right ventricle size 0.051420152943496 0.174379864276682 1.11286425538146 0.75 30.4 30 4 delayed suture closure 0.051420152943496 0.174379864276682 1.11286425538146 0.75 30.4 30 4 abnormal visual evoked potential 0.051420152943496 0.174379864276682 1.11286425538146 0.75 30.4 30 4 abnormal anterior commissure pars posterior morphology 0.051420152943496 0.174379864276682 1.11286425538146 0.75 30.4 30 4 abnormal foramen magnum morphology 0.051420152943496 0.174379864276682 1.11286425538146 0.75 30.4 30 4 abnormal macrophage activation involved in immune response 0.051420152943496 0.174379864276682 1.11286425538146 0.75 30.4 30 4 lethality during fetal growth through weaning, incomplete penetrance 0.051420152943496 0.174379864276682 1.11286425538146 0.75 30.4 30 4 abnormal heart echocardiography feature 0.051420152943496 0.174379864276682 1.11286425538146 0.75 30.4 30 4 increased cornea thickness 0.051420152943496 0.174379864276682 1.11286425538146 0.75 30.4 30 4 absent hypoglossal canal 0.051420152943496 0.174379864276682 1.11286425538146 0.75 30.4 30 4 decreased basal metabolism 0.051420152943496 0.174379864276682 1.11286425538146 0.75 30.4 30 4 decreased birth body size 1.01224245211087e-13 9.08425790583918e-12 1.10635627727982 0.745614035087719 30.4 30 4 abnormal trophoblast layer morphology 7.14244203250888e-07 1.69207852913008e-05 1.10559063279727 0.745098039215686 30.4 30 4 abnormal cell nucleus morphology 2.0145620942151e-06 4.2111119406387e-05 1.10497160108798 0.74468085106383 30.4 30 4 increased respiratory quotient 2.0145620942151e-06 4.2111119406387e-05 1.10497160108798 0.74468085106383 30.4 30 4 abnormal homeostasis 5.69951949493992e-06 0.000108225608730252 1.10423740068858 0.744186046511628 30.4 30 4 pale liver 2.76483467404277e-09 1.10927842769055e-07 1.10283845127893 0.743243243243243 30.4 30 4 lethality throughout fetal growth and development, incomplete penetrance 2.02334452596802e-20 5.29796790352153e-18 1.10250239080622 0.743016759776536 30.4 30 4 abnormal liver development 4.61596847426043e-05 0.000659217853111568 1.10226554818735 0.742857142857143 30.4 30 4 abnormal eyelid morphology 0.000132385092305967 0.00163023721342126 1.10089797306553 0.741935483870968 30.4 30 4 increased cell proliferation 4.73831592294095e-07 1.18457898073524e-05 1.09912519050021 0.740740740740741 30.4 30 4 abnormal mandible morphology 4.73831592294095e-07 1.18457898073524e-05 1.09912519050021 0.740740740740741 30.4 30 4 abnormal heart valve morphology 0.000382345304357223 0.00388991388379793 1.09912519050021 0.740740740740741 30.4 30 4 increased brain weight 0.000382345304357223 0.00388991388379793 1.09912519050021 0.740740740740741 30.4 30 4 decreased bone ossification 0.000382345304357223 0.00388991388379793 1.09912519050021 0.740740740740741 30.4 30 4 short stride length 1.33291172039752e-06 2.93417513671578e-05 1.09802606530971 0.74 30.4 30 4 increased B cell derived lymphoma incidence 1.33291172039752e-06 2.93417513671578e-05 1.09802606530971 0.74 30.4 30 4 abnormal cell cycle 2.3456536355633e-13 1.94493780615457e-11 1.09673578791216 0.739130434782609 30.4 30 4 microcephaly 1.43325171620284e-08 5.20469145117453e-07 1.09673578791216 0.739130434782609 30.4 30 4 abnormal cell death 3.75919066812734e-06 7.48078942957341e-05 1.09673578791216 0.739130434782609 30.4 30 4 abnormal myelin sheath morphology 3.75919066812734e-06 7.48078942957341e-05 1.09673578791216 0.739130434782609 30.4 30 4 embryonic lethality between implantation and somite formation, complete penetrance 9.38829547895824e-27 3.89223083398477e-24 1.09620914407643 0.738775510204082 30.4 30 4 abnormal stationary movement 0.00328862699325984 0.0219021677261951 1.09334032107652 0.736842105263158 30.4 30 4 decreased tumor incidence 0.00328862699325984 0.0219021677261951 1.09334032107652 0.736842105263158 30.4 30 4 abnormal neurotransmitter level 0.00328862699325984 0.0219021677261951 1.09334032107652 0.736842105263158 30.4 30 4 decreased susceptibility to weight gain 0.00328862699325984 0.0219021677261951 1.09334032107652 0.736842105263158 30.4 30 4 pale yolk sac 8.15493103613706e-10 3.53523867149865e-08 1.09051758358665 0.734939759036145 30.4 30 4 abnormal response to infection 2.26507957084338e-09 9.3130337726825e-08 1.08938610653375 0.734177215189873 30.4 30 4 abnormal incisor morphology 2.06624039702836e-07 5.58670976913918e-06 1.08813393859521 0.733333333333333 30.4 30 4 abnormal myocardial trabeculae morphology 6.96549926344917e-06 0.000129787860807714 1.08813393859521 0.733333333333333 30.4 30 4 abnormal heart tube morphology 0.000246914489806698 0.00272701717394752 1.08813393859521 0.733333333333333 30.4 30 4 liver hemorrhage 0.000246914489806698 0.00272701717394752 1.08813393859521 0.733333333333333 30.4 30 4 macrocytosis 0.00987847305080494 0.0505611146376076 1.08813393859521 0.733333333333333 30.4 30 4 abnormal pup retrieval 0.00987847305080494 0.0505611146376076 1.08813393859521 0.733333333333333 30.4 30 4 absent egg cylinders 0.00987847305080494 0.0505611146376076 1.08813393859521 0.733333333333333 30.4 30 4 abnormal placenta size 0.00987847305080494 0.0505611146376076 1.08813393859521 0.733333333333333 30.4 30 4 abnormal secondary palate development 0.00987847305080494 0.0505611146376076 1.08813393859521 0.733333333333333 30.4 30 4 liver vascular congestion 0.00987847305080494 0.0505611146376076 1.08813393859521 0.733333333333333 30.4 30 4 bicuspid aortic valve 0.00987847305080494 0.0505611146376076 1.08813393859521 0.733333333333333 30.4 30 4 increased embryonic tissue cell apoptosis 4.15973298955778e-09 1.61677122055078e-07 1.08432927447424 0.730769230769231 30.4 30 4 distended pericardium 1.62050832175187e-06 3.47162754155924e-05 1.08432927447424 0.730769230769231 30.4 30 4 kinked neural tube 1.62050832175187e-06 3.47162754155924e-05 1.08432927447424 0.730769230769231 30.4 30 4 abnormal ureter morphology 0.000712986864170237 0.00636498447056142 1.08432927447424 0.730769230769231 30.4 30 4 decreased bone resorption 0.000712986864170237 0.00636498447056142 1.08432927447424 0.730769230769231 30.4 30 4 decreased hemoglobin content 2.6853400658844e-15 3.33989170694372e-13 1.08392452297201 0.730496453900709 30.4 30 4 gliosis 1.35953607371656e-07 3.7785988641005e-06 1.08342340206449 0.73015873015873 30.4 30 4 increased monocyte cell number 3.09035385378735e-11 1.85235065332434e-09 1.08318787523796 0.73 30.4 30 4 malocclusion 5.58544311021273e-05 0.000782748717557981 1.08278684307385 0.72972972972973 30.4 30 4 abnormal long bone metaphysis morphology 5.58544311021273e-05 0.000782748717557981 1.08278684307385 0.72972972972973 30.4 30 4 overriding aortic valve 4.55119240494572e-06 8.87928714298234e-05 1.08195135939864 0.729166666666667 30.4 30 4 domed cranium 3.21013540621581e-08 1.0285766611822e-06 1.08106813379913 0.728571428571429 30.4 30 4 abnormal embryo development 1.34985948548516e-14 1.45990237832362e-12 1.08013295375259 0.727941176470588 30.4 30 4 osteoporosis 1.28116356591144e-05 0.000216795535388075 1.07914109612748 0.727272727272727 30.4 30 4 muscular atrophy 1.28116356591144e-05 0.000216795535388075 1.07914109612748 0.727272727272727 30.4 30 4 increased cardiomyocyte apoptosis 0.000159116779574829 0.00192431243020913 1.07914109612748 0.727272727272727 30.4 30 4 abnormal facial nerve morphology 0.00207755451102602 0.0149794691193543 1.07914109612748 0.727272727272727 30.4 30 4 testis hypoplasia 0.00207755451102602 0.0149794691193543 1.07914109612748 0.727272727272727 30.4 30 4 abnormal mesenteric lymph node morphology 0.00207755451102602 0.0149794691193543 1.07914109612748 0.727272727272727 30.4 30 4 abnormal occipital bone morphology 0.00207755451102602 0.0149794691193543 1.07914109612748 0.727272727272727 30.4 30 4 rough coat 0.00207755451102602 0.0149794691193543 1.07914109612748 0.727272727272727 30.4 30 4 increased mammary gland tumor incidence 0.00207755451102602 0.0149794691193543 1.07914109612748 0.727272727272727 30.4 30 4 premature suture closure 0.0304975906897968 0.115821002810488 1.07914109612748 0.727272727272727 30.4 30 4 abnormal thrombopoiesis 0.0304975906897968 0.115821002810488 1.07914109612748 0.727272727272727 30.4 30 4 abnormal stomach epithelium morphology 0.0304975906897968 0.115821002810488 1.07914109612748 0.727272727272727 30.4 30 4 abnormal large intestine morphology 0.0304975906897968 0.115821002810488 1.07914109612748 0.727272727272727 30.4 30 4 impaired myelopoiesis 0.0304975906897968 0.115821002810488 1.07914109612748 0.727272727272727 30.4 30 4 focal hepatic necrosis 0.0304975906897968 0.115821002810488 1.07914109612748 0.727272727272727 30.4 30 4 abnormal primary sex determination 0.0304975906897968 0.115821002810488 1.07914109612748 0.727272727272727 30.4 30 4 pulmonary hypertension 0.0304975906897968 0.115821002810488 1.07914109612748 0.727272727272727 30.4 30 4 pathological neovascularization 0.0304975906897968 0.115821002810488 1.07914109612748 0.727272727272727 30.4 30 4 abnormal hair medulla 0.0304975906897968 0.115821002810488 1.07914109612748 0.727272727272727 30.4 30 4 abnormal coronal suture morphology 0.0304975906897968 0.115821002810488 1.07914109612748 0.727272727272727 30.4 30 4 pharyngeal arch hypoplasia 0.0304975906897968 0.115821002810488 1.07914109612748 0.727272727272727 30.4 30 4 cyclopia 0.0304975906897968 0.115821002810488 1.07914109612748 0.727272727272727 30.4 30 4 abnormal dorsal-ventral polarity of the somites 0.0304975906897968 0.115821002810488 1.07914109612748 0.727272727272727 30.4 30 4 increased glycogen level 0.0304975906897968 0.115821002810488 1.07914109612748 0.727272727272727 30.4 30 4 increased circulating triiodothyronine level 0.0304975906897968 0.115821002810488 1.07914109612748 0.727272727272727 30.4 30 4 palatal shelf hypoplasia 0.0304975906897968 0.115821002810488 1.07914109612748 0.727272727272727 30.4 30 4 thin hypoglossal nerve 0.0304975906897968 0.115821002810488 1.07914109612748 0.727272727272727 30.4 30 4 abnormal lens morphology 1.0225496336221e-13 9.08425790583918e-12 1.07808724740079 0.7265625 30.4 30 4 decreased embryo size 3.86201424504393e-47 3.84270417381871e-44 1.07716568094105 0.725941422594142 30.4 30 4 abnormal extraembryonic tissue morphology 3.72016628071712e-11 2.20331276744853e-09 1.0764961424605 0.725490196078431 30.4 30 4 abnormal B cell differentiation 4.30089644953731e-10 2.03780569870935e-08 1.07617642278647 0.725274725274725 30.4 30 4 increased grip strength 4.30089644953731e-10 2.03780569870935e-08 1.07617642278647 0.725274725274725 30.4 30 4 cleft palate 6.75512413967404e-14 6.34089482922233e-12 1.07605195176833 0.725190839694656 30.4 30 4 decreased cell proliferation 6.31163341848679e-19 1.30834901070716e-16 1.07476619979183 0.724324324324324 30.4 30 4 abnormal neural tube morphology 1.48609980996196e-16 2.38495050147121e-14 1.0716470607377 0.722222222222222 30.4 30 4 hydrops fetalis 3.83281386517842e-08 1.19926094209199e-06 1.0716470607377 0.722222222222222 30.4 30 4 narrow eye opening 0.000102403921207649 0.00129964160206136 1.0716470607377 0.722222222222222 30.4 30 4 delayed kidney development 0.00612833140933302 0.0350039595424016 1.0716470607377 0.722222222222222 30.4 30 4 abnormal thymus medulla morphology 0.00612833140933302 0.0350039595424016 1.0716470607377 0.722222222222222 30.4 30 4 decreased cellular sensitivity to gamma-irradiation 0.00612833140933302 0.0350039595424016 1.0716470607377 0.722222222222222 30.4 30 4 long tibia 0.00612833140933302 0.0350039595424016 1.0716470607377 0.722222222222222 30.4 30 4 abnormal anterior eye segment morphology 0.00612833140933302 0.0350039595424016 1.0716470607377 0.722222222222222 30.4 30 4 jerky movement 0.00612833140933302 0.0350039595424016 1.0716470607377 0.722222222222222 30.4 30 4 abnormal nervous system morphology 9.0686077562271e-09 3.36688981994253e-07 1.07060358745558 0.721518987341772 30.4 30 4 abnormal embryonic tissue morphology 4.64927741041927e-15 5.37910584112463e-13 1.06996472626245 0.72108843537415 30.4 30 4 embryonic lethality, complete penetrance 5.96515203387845e-31 3.29740348539392e-28 1.06983815564362 0.721003134796238 30.4 30 4 abnormal liver physiology 1.21988932681992e-10 6.38836779045171e-09 1.0683496851662 0.72 30.4 30 4 spontaneous skin ulceration 0.00131346527691636 0.0107652219977906 1.0683496851662 0.72 30.4 30 4 spleen hyperplasia 2.50650593627909e-08 8.31324468865897e-07 1.0683496851662 0.72 30.4 30 4 double outlet right ventricle 2.91210706057674e-11 1.76679666175235e-09 1.06779498647193 0.719626168224299 30.4 30 4 abnormal developmental patterning 5.93580350275698e-09 2.25424598673404e-07 1.06762587101636 0.719512195121951 30.4 30 4 abnormal cell morphology 6.96125790379833e-12 4.74414494128722e-10 1.06730840866994 0.719298245614035 30.4 30 4 abnormal osteoclast physiology 2.9439261517884e-07 7.58861793012812e-06 1.06649491140723 0.71875 30.4 30 4 abnormal tooth morphology 2.9439261517884e-07 7.58861793012812e-06 1.06649491140723 0.71875 30.4 30 4 abnormal spongiotrophoblast layer morphology 0.000291098326418282 0.00310775573804926 1.06649491140723 0.71875 30.4 30 4 pancreatic islet hyperplasia 0.000291098326418282 0.00310775573804926 1.06649491140723 0.71875 30.4 30 4 abnormal craniofacial morphology 7.99906392288045e-11 4.27906914154089e-09 1.06604472360166 0.718446601941748 30.4 30 4 increased circulating free fatty acid level 6.92957695672447e-08 2.03991984376948e-06 1.06584182205548 0.71830985915493 30.4 30 4 failure of heart looping 6.58527887863872e-05 0.00089513012079857 1.06530595386943 0.717948717948718 30.4 30 4 atrial septal defect 1.51045903131124e-05 0.000246378153467981 1.06447885297357 0.717391304347826 30.4 30 4 abnormal eating behavior 8.16516114292922e-07 1.90712097117713e-05 1.06340362180895 0.716666666666667 30.4 30 4 embryonic growth arrest 5.58813905688287e-22 1.85339945386615e-19 1.0626476732609 0.716157205240175 30.4 30 4 abnormal long bone hypertrophic chondrocyte zone 9.75076466173719e-06 0.000171413619053507 1.05987071941092 0.714285714285714 30.4 30 4 absent kidney 9.75076466173719e-06 0.000171413619053507 1.05987071941092 0.714285714285714 30.4 30 4 increased T cell derived lymphoma incidence 9.75076466173719e-06 0.000171413619053507 1.05987071941092 0.714285714285714 30.4 30 4 increased triglyceride level 0.000831351655678218 0.00725609559122655 1.05987071941092 0.714285714285714 30.4 30 4 translucent skin 0.0183945266929803 0.0819272786907582 1.05987071941092 0.714285714285714 30.4 30 4 abnormal pinna reflex 0.0183945266929803 0.0819272786907582 1.05987071941092 0.714285714285714 30.4 30 4 extended life span 0.0183945266929803 0.0819272786907582 1.05987071941092 0.714285714285714 30.4 30 4 abnormal antigen presentation 0.0183945266929803 0.0819272786907582 1.05987071941092 0.714285714285714 30.4 30 4 abnormal sagittal suture morphology 0.0183945266929803 0.0819272786907582 1.05987071941092 0.714285714285714 30.4 30 4 abnormal pancreas development 0.0183945266929803 0.0819272786907582 1.05987071941092 0.714285714285714 30.4 30 4 split sternum 0.0183945266929803 0.0819272786907582 1.05987071941092 0.714285714285714 30.4 30 4 decreased CNS synapse formation 0.0183945266929803 0.0819272786907582 1.05987071941092 0.714285714285714 30.4 30 4 decreased tongue size 0.0183945266929803 0.0819272786907582 1.05987071941092 0.714285714285714 30.4 30 4 pulmonary alveolar hemorrhage 0.0183945266929803 0.0819272786907582 1.05987071941092 0.714285714285714 30.4 30 4 growth retardation of molars 0.0987765542784683 0.267508632300152 1.05987071941092 0.714285714285714 30.4 30 4 failure of atrioventricular cushion closure 0.0987765542784683 0.267508632300152 1.05987071941092 0.714285714285714 30.4 30 4 abnormal foot pad morphology 0.0987765542784683 0.267508632300152 1.05987071941092 0.714285714285714 30.4 30 4 excessive tearing 0.0987765542784683 0.267508632300152 1.05987071941092 0.714285714285714 30.4 30 4 abnormal circulating free fatty acids level 0.0987765542784683 0.267508632300152 1.05987071941092 0.714285714285714 30.4 30 4 increased chemically-elicited antinociception 0.0987765542784683 0.267508632300152 1.05987071941092 0.714285714285714 30.4 30 4 abnormal tumor incidence 0.0987765542784683 0.267508632300152 1.05987071941092 0.714285714285714 30.4 30 4 abnormal lymph node primary follicle morphology 0.0987765542784683 0.267508632300152 1.05987071941092 0.714285714285714 30.4 30 4 detached tectorial membrane 0.0987765542784683 0.267508632300152 1.05987071941092 0.714285714285714 30.4 30 4 absent tunnel of Corti 0.0987765542784683 0.267508632300152 1.05987071941092 0.714285714285714 30.4 30 4 decreased lateral semicircular canal size 0.0987765542784683 0.267508632300152 1.05987071941092 0.714285714285714 30.4 30 4 abnormal sinus venosus morphology 0.0987765542784683 0.267508632300152 1.05987071941092 0.714285714285714 30.4 30 4 abnormal neurotransmitter uptake 0.0987765542784683 0.267508632300152 1.05987071941092 0.714285714285714 30.4 30 4 abnormal response to novel odor 0.0987765542784683 0.267508632300152 1.05987071941092 0.714285714285714 30.4 30 4 abnormal hard palate morphology 0.0987765542784683 0.267508632300152 1.05987071941092 0.714285714285714 30.4 30 4 absent thyroid gland 0.0987765542784683 0.267508632300152 1.05987071941092 0.714285714285714 30.4 30 4 atherosclerotic lesions 0.0987765542784683 0.267508632300152 1.05987071941092 0.714285714285714 30.4 30 4 increased chronic myelocytic leukemia incidence 0.0987765542784683 0.267508632300152 1.05987071941092 0.714285714285714 30.4 30 4 abnormal renal filtration rate 0.0987765542784683 0.267508632300152 1.05987071941092 0.714285714285714 30.4 30 4 decreased tidal volume 0.0987765542784683 0.267508632300152 1.05987071941092 0.714285714285714 30.4 30 4 absent popliteal lymph nodes 0.0987765542784683 0.267508632300152 1.05987071941092 0.714285714285714 30.4 30 4 heart hemorrhage 0.0987765542784683 0.267508632300152 1.05987071941092 0.714285714285714 30.4 30 4 postaxial polydactyly 0.0987765542784683 0.267508632300152 1.05987071941092 0.714285714285714 30.4 30 4 enhanced behavioral response to alcohol 0.0987765542784683 0.267508632300152 1.05987071941092 0.714285714285714 30.4 30 4 decreased DN2 thymocyte number 0.0987765542784683 0.267508632300152 1.05987071941092 0.714285714285714 30.4 30 4 increased DN3 thymocyte number 0.0987765542784683 0.267508632300152 1.05987071941092 0.714285714285714 30.4 30 4 arteritis 0.0987765542784683 0.267508632300152 1.05987071941092 0.714285714285714 30.4 30 4 decreased brain cholesterol level 0.0987765542784683 0.267508632300152 1.05987071941092 0.714285714285714 30.4 30 4 focal dorsal hair loss 0.0987765542784683 0.267508632300152 1.05987071941092 0.714285714285714 30.4 30 4 decreased skeletal muscle glycogen level 0.0987765542784683 0.267508632300152 1.05987071941092 0.714285714285714 30.4 30 4 abnormal conotruncal ridge morphology 0.0987765542784683 0.267508632300152 1.05987071941092 0.714285714285714 30.4 30 4 abnormal aortic valve cusp morphology 0.0987765542784683 0.267508632300152 1.05987071941092 0.714285714285714 30.4 30 4 thick mitral valve cusps 0.0987765542784683 0.267508632300152 1.05987071941092 0.714285714285714 30.4 30 4 impaired branching involved in bronchus morphogenesis 0.0987765542784683 0.267508632300152 1.05987071941092 0.714285714285714 30.4 30 4 embryonic lethality at implantation, incomplete penetrance 0.0987765542784683 0.267508632300152 1.05987071941092 0.714285714285714 30.4 30 4 decreased CD8-positive, naive alpha-beta T cell number 0.0987765542784683 0.267508632300152 1.05987071941092 0.714285714285714 30.4 30 4 decreased areal bone mineral density 0.0987765542784683 0.267508632300152 1.05987071941092 0.714285714285714 30.4 30 4 abnormal Mullerian duct topology 0.0987765542784683 0.267508632300152 1.05987071941092 0.714285714285714 30.4 30 4 abnormal reproductive system morphology 4.23288740139231e-05 0.000613953784895824 1.05987071941092 0.714285714285714 30.4 30 4 thick pulmonary interalveolar septum 0.000185971973275129 0.00216170693234525 1.05987071941092 0.714285714285714 30.4 30 4 abnormal artery morphology 0.000185971973275129 0.00216170693234525 1.05987071941092 0.714285714285714 30.4 30 4 increased circulating serum albumin level 0.000185971973275129 0.00216170693234525 1.05987071941092 0.714285714285714 30.4 30 4 decreased bone volume 0.000185971973275129 0.00216170693234525 1.05987071941092 0.714285714285714 30.4 30 4 decreased cochlear outer hair cell number 0.00381818808902688 0.0247015419283598 1.05987071941092 0.714285714285714 30.4 30 4 increased keratinocyte proliferation 0.00381818808902688 0.0247015419283598 1.05987071941092 0.714285714285714 30.4 30 4 abnormal axon morphology 6.140199592643e-11 3.43230258128078e-09 1.05790799585645 0.712962962962963 30.4 30 4 abnormal pulmonary alveolus morphology 2.57297677830908e-10 1.30617953796813e-08 1.05777196551109 0.712871287128713 30.4 30 4 microphthalmia 7.59520757203348e-15 8.58776310701513e-13 1.05709981556932 0.712418300653595 30.4 30 4 reduced fertility 1.31863882070299e-13 1.15091721631533e-11 1.05682073172916 0.712230215827338 30.4 30 4 irregular heartbeat 2.72021252484439e-05 0.000412593210704294 1.0551601828802 0.711111111111111 30.4 30 4 abnormal ectoderm development 2.72021252484439e-05 0.000412593210704294 1.0551601828802 0.711111111111111 30.4 30 4 albuminuria 2.72021252484439e-05 0.000412593210704294 1.0551601828802 0.711111111111111 30.4 30 4 cataract 6.26105519824036e-12 4.32621522378414e-10 1.05461516212458 0.710743801652893 30.4 30 4 impaired branching involved in ureteric bud morphogenesis 0.000118841358288964 0.00147994151741772 1.05429245246665 0.710526315789474 30.4 30 4 lethality throughout fetal growth and development, complete penetrance 7.09518706590068e-18 1.26066270188771e-15 1.05429245246665 0.710526315789474 30.4 30 4 autoimmune response 0.000526875239252926 0.00506023999089441 1.05303284380181 0.709677419354839 30.4 30 4 abnormal postnatal growth/weight/body size 0.000526875239252926 0.00506023999089441 1.05303284380181 0.709677419354839 30.4 30 4 embryonic lethality during organogenesis, incomplete penetrance 4.33435260869657e-21 1.1979669015703e-18 1.05157607899813 0.708695652173913 30.4 30 4 decreased body height 0.00238787659235148 0.016922629696508 1.05103846341582 0.708333333333333 30.4 30 4 blindness 0.00238787659235148 0.016922629696508 1.05103846341582 0.708333333333333 30.4 30 4 abnormal tumor morphology 0.00238787659235148 0.016922629696508 1.05103846341582 0.708333333333333 30.4 30 4 abnormal embryo size 4.65025230352079e-11 2.65919600115126e-09 1.05049133251347 0.707964601769911 30.4 30 4 palatal shelves fail to meet at midline 7.5972572760089e-05 0.00100522220606767 1.04953051727032 0.707317073170732 30.4 30 4 decreased osteoblast cell number 0.000334342523607011 0.003494441291901 1.04740165212373 0.705882352941177 30.4 30 4 abnormal bone marrow cavity morphology 0.0112241642667756 0.0551236102933943 1.04740165212373 0.705882352941177 30.4 30 4 abnormal involuntary movement 0.0112241642667756 0.0551236102933943 1.04740165212373 0.705882352941177 30.4 30 4 abnormal testis development 0.0112241642667756 0.0551236102933943 1.04740165212373 0.705882352941177 30.4 30 4 enhanced behavioral response to cocaine 0.0112241642667756 0.0551236102933943 1.04740165212373 0.705882352941177 30.4 30 4 increased circulating magnesium level 0.0112241642667756 0.0551236102933943 1.04740165212373 0.705882352941177 30.4 30 4 increased hepatoma incidence 0.0112241642667756 0.0551236102933943 1.04740165212373 0.705882352941177 30.4 30 4 common atrium 0.0112241642667756 0.0551236102933943 1.04740165212373 0.705882352941177 30.4 30 4 increased trabecular bone mass 0.0112241642667756 0.0551236102933943 1.04740165212373 0.705882352941177 30.4 30 4 delayed heart development 0.0112241642667756 0.0551236102933943 1.04740165212373 0.705882352941177 30.4 30 4 abnormal cell cytoskeleton morphology 0.0112241642667756 0.0551236102933943 1.04740165212373 0.705882352941177 30.4 30 4 embryonic lethality during organogenesis, complete penetrance 2.44167070325586e-48 3.03682793717448e-45 1.04662233541828 0.705357142857143 30.4 30 4 insulin resistance 2.00313851741497e-12 1.46553148884404e-10 1.04541793687349 0.704545454545455 30.4 30 4 abnormal myelopoiesis 4.85898544370177e-05 0.000688702352775393 1.04541793687349 0.704545454545455 30.4 30 4 short snout 2.23717212245062e-10 1.15936784470748e-08 1.0441689309752 0.703703703703704 30.4 30 4 abnormal maxilla morphology 7.21915084801962e-06 0.000133019538773695 1.0441689309752 0.703703703703704 30.4 30 4 impaired limb coordination 7.21915084801962e-06 0.000133019538773695 1.0441689309752 0.703703703703704 30.4 30 4 abnormal bone trabecula morphology 0.00149826056872614 0.0118691820532047 1.0441689309752 0.703703703703704 30.4 30 4 abnormal vocalization 0.000212429988729792 0.00243511335007077 1.04268362666371 0.702702702702703 30.4 30 4 decreased width of hypertrophic chondrocyte zone 0.000212429988729792 0.00243511335007077 1.04268362666371 0.702702702702703 30.4 30 4 increased tumor incidence 1.46983581345334e-11 9.37491432298767e-10 1.04106656148588 0.701612903225806 30.4 30 4 preweaning lethality, complete penetrance 5.70377934649957e-62 9.45876741627845e-59 1.0406784658432 0.701351351351351 30.4 30 4 decreased double-positive T cell number 1.64611662244331e-09 6.88187411483654e-08 1.0386733050227 0.7 30.4 30 4 thick epidermis 4.52394578241562e-07 1.14246854149836e-05 1.0386733050227 0.7 30.4 30 4 increased mammary adenocarcinoma incidence 0.00690759945744435 0.0386127048323434 1.0386733050227 0.7 30.4 30 4 spleen atrophy 0.00690759945744435 0.0386127048323434 1.0386733050227 0.7 30.4 30 4 abnormal heart electrocardiography waveform feature 0.00690759945744435 0.0386127048323434 1.0386733050227 0.7 30.4 30 4 absent maxillary shelf 0.0566971082463925 0.187670068879443 1.0386733050227 0.7 30.4 30 4 abnormal epidermis suprabasal layer morphology 0.0566971082463925 0.187670068879443 1.0386733050227 0.7 30.4 30 4 abnormal grooming behavior 0.0566971082463925 0.187670068879443 1.0386733050227 0.7 30.4 30 4 absent trophoblast giant cells 0.0566971082463925 0.187670068879443 1.0386733050227 0.7 30.4 30 4 abnormal immune cell physiology 0.0566971082463925 0.187670068879443 1.0386733050227 0.7 30.4 30 4 rhinitis 0.0566971082463925 0.187670068879443 1.0386733050227 0.7 30.4 30 4 decreased incidence of induced tumors 0.0566971082463925 0.187670068879443 1.0386733050227 0.7 30.4 30 4 abnormal neuron specification 0.0566971082463925 0.187670068879443 1.0386733050227 0.7 30.4 30 4 impaired social transmission of food preference 0.0566971082463925 0.187670068879443 1.0386733050227 0.7 30.4 30 4 primary sex reversal 0.0566971082463925 0.187670068879443 1.0386733050227 0.7 30.4 30 4 abnormal hypaxial muscle morphology 0.0566971082463925 0.187670068879443 1.0386733050227 0.7 30.4 30 4 abnormal glial cell physiology 0.0566971082463925 0.187670068879443 1.0386733050227 0.7 30.4 30 4 increased left ventricle diastolic pressure 0.0566971082463925 0.187670068879443 1.0386733050227 0.7 30.4 30 4 abnormal pillar cell morphology 0.0566971082463925 0.187670068879443 1.0386733050227 0.7 30.4 30 4 abnormal gas homeostasis 0.0566971082463925 0.187670068879443 1.0386733050227 0.7 30.4 30 4 abnormal plasma membrane morphology 0.0566971082463925 0.187670068879443 1.0386733050227 0.7 30.4 30 4 abnormal placental transport 0.0566971082463925 0.187670068879443 1.0386733050227 0.7 30.4 30 4 increased susceptibility to atherosclerosis 0.0566971082463925 0.187670068879443 1.0386733050227 0.7 30.4 30 4 absent inguinal lymph nodes 0.0566971082463925 0.187670068879443 1.0386733050227 0.7 30.4 30 4 increased serotonin level 0.0566971082463925 0.187670068879443 1.0386733050227 0.7 30.4 30 4 abnormal inferior vena cava valve morphology 0.0566971082463925 0.187670068879443 1.0386733050227 0.7 30.4 30 4 thick aortic valve 0.0566971082463925 0.187670068879443 1.0386733050227 0.7 30.4 30 4 sinus bradycardia 0.0566971082463925 0.187670068879443 1.0386733050227 0.7 30.4 30 4 increased compact bone area 0.0566971082463925 0.187670068879443 1.0386733050227 0.7 30.4 30 4 increased fatty acid oxidation 0.0566971082463925 0.187670068879443 1.0386733050227 0.7 30.4 30 4 abnormal fertility/fecundity 2.9170094741244e-07 7.58861793012812e-06 1.03664067624574 0.698630136986301 30.4 30 4 extramedullary hematopoiesis 6.90775157663958e-10 3.06839857980195e-08 1.03587364651859 0.69811320754717 30.4 30 4 prenatal lethality, complete penetrance 1.61365516937346e-23 5.73423890545211e-21 1.03547081795685 0.697841726618705 30.4 30 4 limb grasping 6.63643387465153e-16 9.4332167218261e-14 1.03541216434759 0.697802197802198 30.4 30 4 edema 4.23073278345046e-15 5.01140371373e-13 1.03522256314555 0.697674418604651 30.4 30 4 abnormal organ of Corti morphology 8.60513378337924e-05 0.00110336444773999 1.03522256314555 0.697674418604651 30.4 30 4 delayed endochondral bone ossification 8.60513378337924e-05 0.00110336444773999 1.03522256314555 0.697674418604651 30.4 30 4 abnormal neuron morphology 2.8837447079216e-09 1.1477303937528e-07 1.03417688378883 0.696969696969697 30.4 30 4 short mandible 8.17063861409001e-06 0.000147814280382174 1.03337395142564 0.696428571428571 30.4 30 4 abnormal heart development 7.2556740187779e-14 6.68462560063334e-12 1.03303854929925 0.69620253164557 30.4 30 4 decreased B cell proliferation 1.21297707295387e-07 3.40935646211611e-06 1.03303854929925 0.69620253164557 30.4 30 4 perimembraneous ventricular septal defect 7.93677732131875e-07 1.86252203648872e-05 1.03222191803498 0.695652173913043 30.4 30 4 abnormal lens development 0.00427904370215106 0.0263142675132281 1.03222191803498 0.695652173913043 30.4 30 4 abnormal chondrocyte physiology 0.00427904370215106 0.0263142675132281 1.03222191803498 0.695652173913043 30.4 30 4 abnormal basicranium morphology 0.00427904370215106 0.0263142675132281 1.03222191803498 0.695652173913043 30.4 30 4 abnormal forebrain development 5.10680798527252e-07 1.2639984938672e-05 1.03042986609395 0.694444444444444 30.4 30 4 renal hypoplasia 0.000375899364337582 0.00384794102382607 1.03042986609395 0.694444444444444 30.4 30 4 decreased kidney weight 2.23504813268386e-05 0.000349665549059817 1.02725931265981 0.692307692307692 30.4 30 4 abnormal iris morphology 0.000238065639669761 0.00264961198513884 1.02725931265981 0.692307692307692 30.4 30 4 abnormal erythrocyte osmotic lysis 0.00266454170559516 0.0186968899652129 1.02725931265981 0.692307692307692 30.4 30 4 short premaxilla 0.0335070613112237 0.125242396711749 1.02725931265981 0.692307692307692 30.4 30 4 absent myocardial trabeculae 0.0335070613112237 0.125242396711749 1.02725931265981 0.692307692307692 30.4 30 4 short hair 0.0335070613112237 0.125242396711749 1.02725931265981 0.692307692307692 30.4 30 4 anal atresia 0.0335070613112237 0.125242396711749 1.02725931265981 0.692307692307692 30.4 30 4 muscle fatigue 0.0335070613112237 0.125242396711749 1.02725931265981 0.692307692307692 30.4 30 4 abnormal retinal inner plexiform layer morphology 0.0335070613112237 0.125242396711749 1.02725931265981 0.692307692307692 30.4 30 4 small interparietal bone 0.0335070613112237 0.125242396711749 1.02725931265981 0.692307692307692 30.4 30 4 abnormal vertebral arch development 0.0335070613112237 0.125242396711749 1.02725931265981 0.692307692307692 30.4 30 4 abnormal aorta tunica media morphology 0.0335070613112237 0.125242396711749 1.02725931265981 0.692307692307692 30.4 30 4 decreased cardiac stroke volume 0.0335070613112237 0.125242396711749 1.02725931265981 0.692307692307692 30.4 30 4 preweaning lethality, incomplete penetrance 1.22826203555552e-32 7.63825453361091e-30 1.02670117122397 0.691931540342298 30.4 30 4 ventricular septal defect 8.93594802523866e-12 5.84951860862662e-10 1.02558078437115 0.691176470588235 30.4 30 4 abnormal head morphology 1.42843264274935e-05 0.000236881746589266 1.0251840413211 0.690909090909091 30.4 30 4 abnormal embryo turning 1.42843264274935e-05 0.000236881746589266 1.0251840413211 0.690909090909091 30.4 30 4 decreased exploration in new environment 8.771582583335e-08 2.52246377757755e-06 1.02454169543055 0.69047619047619 30.4 30 4 focal hair loss 0.00166621640085201 0.0129724985825333 1.02332345322433 0.689655172413793 30.4 30 4 increased mortality induced by gamma-irradiation 0.00166621640085201 0.0129724985825333 1.02332345322433 0.689655172413793 30.4 30 4 abnormal embryonic erythropoiesis 0.00166621640085201 0.0129724985825333 1.02332345322433 0.689655172413793 30.4 30 4 kidney cysts 5.71098101462008e-07 1.37922963823956e-05 1.02263201845864 0.689189189189189 30.4 30 4 oxidative stress 3.63956029801477e-08 1.14600079003946e-06 1.02218642716519 0.688888888888889 30.4 30 4 abnormal cell migration 9.59483976402877e-05 0.0012239571237447 1.02218642716519 0.688888888888889 30.4 30 4 lethargy 2.34503749847564e-08 7.82990708383645e-07 1.021122757626 0.688172043010753 30.4 30 4 decreased erythrocyte cell number 4.24538727350234e-13 3.40658091704422e-11 1.02071625971293 0.687898089171974 30.4 30 4 curly tail 6.10385258945438e-05 0.00084586815132411 1.02012556743301 0.6875 30.4 30 4 abnormal depression-related behavior 0.00104558444748914 0.00866963771043077 1.02012556743301 0.6875 30.4 30 4 abnormal auditory brainstem response waveform shape 0.00104558444748914 0.00866963771043077 1.02012556743301 0.6875 30.4 30 4 abnormal tympanic ring morphology 0.0201613271699246 0.0868420802340907 1.02012556743301 0.6875 30.4 30 4 failure of tooth eruption 0.0201613271699246 0.0868420802340907 1.02012556743301 0.6875 30.4 30 4 abnormal mouth morphology 0.0201613271699246 0.0868420802340907 1.02012556743301 0.6875 30.4 30 4 abnormal meiosis 0.0201613271699246 0.0868420802340907 1.02012556743301 0.6875 30.4 30 4 increased intestinal adenocarcinoma incidence 0.0201613271699246 0.0868420802340907 1.02012556743301 0.6875 30.4 30 4 large intestinal inflammation 0.0201613271699246 0.0868420802340907 1.02012556743301 0.6875 30.4 30 4 blepharitis 0.0201613271699246 0.0868420802340907 1.02012556743301 0.6875 30.4 30 4 decreased creatinine clearance 0.0201613271699246 0.0868420802340907 1.02012556743301 0.6875 30.4 30 4 kidney degeneration 0.0201613271699246 0.0868420802340907 1.02012556743301 0.6875 30.4 30 4 impaired somite development 0.0201613271699246 0.0868420802340907 1.02012556743301 0.6875 30.4 30 4 decreased liver cholesterol level 0.0201613271699246 0.0868420802340907 1.02012556743301 0.6875 30.4 30 4 increased heart left ventricle size 0.0201613271699246 0.0868420802340907 1.02012556743301 0.6875 30.4 30 4 hydroencephaly 6.3145396539231e-10 2.882094933786e-08 1.01931914405954 0.68695652173913 30.4 30 4 decreased white adipose tissue amount 2.39938331439715e-06 4.95308381291528e-05 1.01874140791139 0.686567164179104 30.4 30 4 impaired balance 6.27874783666048e-09 2.34862935995382e-07 1.01830716178696 0.686274509803922 30.4 30 4 failure of chorioallantoic fusion 3.88763601127352e-05 0.000572218614085377 1.01830716178696 0.686274509803922 30.4 30 4 abnormal midbrain development 0.000658060087967478 0.00604216366681419 1.01747589063448 0.685714285714286 30.4 30 4 decreased triglyceride level 0.000658060087967478 0.00604216366681419 1.01747589063448 0.685714285714286 30.4 30 4 impaired adaptive thermogenesis 0.000658060087967478 0.00604216366681419 1.01747589063448 0.685714285714286 30.4 30 4 decreased bone mineralization 0.000658060087967478 0.00604216366681419 1.01747589063448 0.685714285714286 30.4 30 4 perinatal lethality, complete penetrance 5.67791231817411e-17 9.74055647686766e-15 1.01707781712484 0.685446009389671 30.4 30 4 abnormal chondrocyte morphology 2.47874275440614e-05 0.000380609419850942 1.01669080121269 0.685185185185185 30.4 30 4 astrocytosis 9.86723953124667e-07 2.26218970820056e-05 1.01631438847622 0.684931506849315 30.4 30 4 decreased hair follicle number 0.000415205354684919 0.00417302351425752 1.01524458385677 0.684210526315789 30.4 30 4 persistence of hyaloid vascular system 0.000415205354684919 0.00417302351425752 1.01524458385677 0.684210526315789 30.4 30 4 abnormal triglyceride level 0.0122810243108249 0.059376186536787 1.01524458385677 0.684210526315789 30.4 30 4 small superior vagus ganglion 0.0122810243108249 0.059376186536787 1.01524458385677 0.684210526315789 30.4 30 4 flaky skin 0.0122810243108249 0.059376186536787 1.01524458385677 0.684210526315789 30.4 30 4 shiny skin 0.0122810243108249 0.059376186536787 1.01524458385677 0.684210526315789 30.4 30 4 delayed sexual maturation 0.0122810243108249 0.059376186536787 1.01524458385677 0.684210526315789 30.4 30 4 abnormal nasal septum morphology 0.0122810243108249 0.059376186536787 1.01524458385677 0.684210526315789 30.4 30 4 abnormal digestive system development 0.0122810243108249 0.059376186536787 1.01524458385677 0.684210526315789 30.4 30 4 abnormal optic vesicle formation 0.0122810243108249 0.059376186536787 1.01524458385677 0.684210526315789 30.4 30 4 abnormal sternebra morphology 0.0122810243108249 0.059376186536787 1.01524458385677 0.684210526315789 30.4 30 4 decreased fertilization frequency 0.0122810243108249 0.059376186536787 1.01524458385677 0.684210526315789 30.4 30 4 thin interventricular septum 0.0122810243108249 0.059376186536787 1.01524458385677 0.684210526315789 30.4 30 4 decreased brain weight 1.58196681290684e-05 0.000255528730331543 1.01524458385677 0.684210526315789 30.4 30 4 abnormal facial morphology 1.58196681290684e-05 0.000255528730331543 1.01524458385677 0.684210526315789 30.4 30 4 abnormal spleen morphology 5.33904530886862e-14 5.10802892531181e-12 1.0147957577808 0.683908045977011 30.4 30 4 polydactyly 1.67518100065813e-08 5.88546756203284e-07 1.01444768857902 0.683673469387755 30.4 30 4 abnormal long bone epiphyseal plate morphology 1.01051942851692e-05 0.000175168437521661 1.01394298823644 0.683333333333333 30.4 30 4 thick ventricular wall 0.000262543676625283 0.00287066987079293 1.01333980977824 0.682926829268293 30.4 30 4 decreased sensitivity to induced morbidity/mortality 0.000166325945112598 0.00199390741430162 1.01169477761951 0.681818181818182 30.4 30 4 abnormal abdominal fat pad morphology 0.00754811718474301 0.0418638606400184 1.01169477761951 0.681818181818182 30.4 30 4 abnormal long bone epiphysis morphology 0.00754811718474301 0.0418638606400184 1.01169477761951 0.681818181818182 30.4 30 4 abnormal tail movements 0.00754811718474301 0.0418638606400184 1.01169477761951 0.681818181818182 30.4 30 4 intracerebral hemorrhage 0.00754811718474301 0.0418638606400184 1.01169477761951 0.681818181818182 30.4 30 4 abnormal oogenesis 0.00754811718474301 0.0418638606400184 1.01169477761951 0.681818181818182 30.4 30 4 pulmonary vascular congestion 0.00754811718474301 0.0418638606400184 1.01169477761951 0.681818181818182 30.4 30 4 increased adenoma incidence 0.00754811718474301 0.0418638606400184 1.01169477761951 0.681818181818182 30.4 30 4 abnormal liver morphology 3.81560153528555e-14 3.72208188981287e-12 1.01131798254405 0.681564245810056 30.4 30 4 abnormal inflammatory response 1.69482459082882e-06 3.58797971888228e-05 1.00982126877207 0.680555555555556 30.4 30 4 decreased circulating alkaline phosphatase level 6.70739154994423e-05 0.000909244494849388 1.00899692487919 0.68 30.4 30 4 abnormal primitive streak morphology 0.00467100063765111 0.0285131634016126 1.00899692487919 0.68 30.4 30 4 increased pre-B cell number 0.00467100063765111 0.0285131634016126 1.00899692487919 0.68 30.4 30 4 diaphragmatic hernia 0.00467100063765111 0.0285131634016126 1.00899692487919 0.68 30.4 30 4 increased cellular sensitivity to ionizing radiation 0.00467100063765111 0.0285131634016126 1.00899692487919 0.68 30.4 30 4 decreased placenta weight 0.00467100063765111 0.0285131634016126 1.00899692487919 0.68 30.4 30 4 decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 0.00467100063765111 0.0285131634016126 1.00899692487919 0.68 30.4 30 4 abnormal placenta development 4.26811143473691e-05 0.000617263208948143 1.00787706147755 0.679245283018868 30.4 30 4 increased circulating alkaline phosphatase level 9.85046139220431e-13 7.5393916040333e-11 1.00753142462519 0.679012345679012 30.4 30 4 rib bifurcation 0.00290617938516064 0.0199975690749297 1.00687718344037 0.678571428571429 30.4 30 4 myoclonus 0.00290617938516064 0.0199975690749297 1.00687718344037 0.678571428571429 30.4 30 4 shortened head 0.00290617938516064 0.0199975690749297 1.00687718344037 0.678571428571429 30.4 30 4 increased bone resorption 0.00290617938516064 0.0199975690749297 1.00687718344037 0.678571428571429 30.4 30 4 short limbs 1.84208852127091e-07 5.09132799629043e-06 1.00626806233726 0.67816091954023 30.4 30 4 increased hemoglobin content 1.73408737790665e-05 0.000278293055002761 1.00597898791545 0.677966101694915 30.4 30 4 decreased bone mineral content 8.2439426845623e-16 1.13926707932493e-13 1.0058580769794 0.677884615384615 30.4 30 4 abnormal definitive hematopoiesis 7.60421804108471e-08 2.22535204437626e-06 1.00516771453809 0.67741935483871 30.4 30 4 osteopetrosis 0.00181605989825051 0.0135050792134474 1.00516771453809 0.67741935483871 30.4 30 4 decreased double-negative T cell number 0.00181605989825051 0.0135050792134474 1.00516771453809 0.67741935483871 30.4 30 4 abnormal mitochondrial ATP synthesis coupled electron transport 0.00181605989825051 0.0135050792134474 1.00516771453809 0.67741935483871 30.4 30 4 abnormal brain morphology 1.67348889883358e-12 1.26145564722683e-10 1.00457311665904 0.677018633540373 30.4 30 4 increased mean corpuscular hemoglobin 3.14324923096161e-08 1.01543278727494e-06 1.00420074222974 0.676767676767677 30.4 30 4 pericardial edema 4.52202937504057e-06 8.85712446489245e-05 1.00375991661857 0.676470588235294 30.4 30 4 abnormal ovary morphology 2.89345357747102e-06 5.8515981902107e-05 1.00314524428751 0.676056338028169 30.4 30 4 thrombocytopenia 2.53497066342023e-11 1.55697272228588e-09 1.00285698415985 0.675862068965517 30.4 30 4 abnormal branching of the mammary ductal tree 0.000716460563520482 0.00636498447056142 1.00258041025357 0.675675675675676 30.4 30 4 abnormal calcium ion homeostasis 0.000716460563520482 0.00636498447056142 1.00258041025357 0.675675675675676 30.4 30 4 skin inflammation 0.000716460563520482 0.00636498447056142 1.00258041025357 0.675675675675676 30.4 30 4 liver inflammation 1.43908582933817e-09 6.06733220420118e-08 1.00157782984332 0.675 30.4 30 4 abnormal vasculogenesis 0.000285609923879224 0.00306230467952401 1.00071514437403 0.674418604651163 30.4 30 4 kidney failure 0.000285609923879224 0.00306230467952401 1.00071514437403 0.674418604651163 30.4 30 4 thymus hypoplasia 1.03114183722349e-10 5.4573730214754e-09 0.999964983096386 0.673913043478261 30.4 30 4 abnormal snout morphology 7.29002282013451e-05 0.000975561865435972 0.998724331752594 0.673076923076923 30.4 30 4 abnormal placenta vasculature 7.29002282013451e-05 0.000975561865435972 0.998724331752594 0.673076923076923 30.4 30 4 increased circulating calcium level 4.63771353947836e-05 0.000659217853111568 0.998205513917917 0.672727272727273 30.4 30 4 decreased circulating calcium level 4.63771353947836e-05 0.000659217853111568 0.998205513917917 0.672727272727273 30.4 30 4 abnormal rostral-caudal axis patterning 4.63771353947836e-05 0.000659217853111568 0.998205513917917 0.672727272727273 30.4 30 4 decreased circulating HDL cholesterol level 6.49856787655021e-10 2.91264641313849e-08 0.996940895445892 0.671875 30.4 30 4 decreased circulating LDL cholesterol level 1.20206513995896e-05 0.000204803906551228 0.996940895445892 0.671875 30.4 30 4 decreased caudal vertebrae number 1.20206513995896e-05 0.000204803906551228 0.996940895445892 0.671875 30.4 30 4 decreased body length 1.70583784237171e-19 3.85751966627239e-17 0.996433201898729 0.671532846715328 30.4 30 4 increased T cell number 3.3961265473467e-07 8.70913895518032e-06 0.994833197992518 0.670454545454545 30.4 30 4 abnormal lipid homeostasis 7.04107056924135e-10 3.09994036123679e-08 0.99301733557115 0.669230769230769 30.4 30 4 decreased grip strength 2.29510754899459e-15 2.92773334775591e-13 0.989212671450188 0.666666666666667 30.4 30 4 decreased circulating cholesterol level 4.38726552097087e-13 3.46454697886192e-11 0.989212671450188 0.666666666666667 30.4 30 4 increased neuron apoptosis 1.38861137923639e-06 3.04332229590355e-05 0.989212671450188 0.666666666666667 30.4 30 4 abnormal vascular development 1.29511806922842e-05 0.00021694317826301 0.989212671450188 0.666666666666667 30.4 30 4 abnormal epidermis stratum granulosum morphology 0.00122238153522727 0.0100851544573062 0.989212671450188 0.666666666666667 30.4 30 4 abnormal epidermis stratum basale morphology 0.00194744157415097 0.0143746614709215 0.989212671450188 0.666666666666667 30.4 30 4 abnormal skeleton physiology 0.00194744157415097 0.0143746614709215 0.989212671450188 0.666666666666667 30.4 30 4 single kidney 0.00194744157415097 0.0143746614709215 0.989212671450188 0.666666666666667 30.4 30 4 increased osteoblast cell number 0.00194744157415097 0.0143746614709215 0.989212671450188 0.666666666666667 30.4 30 4 decreased sensitivity to xenobiotic induced morbidity/mortality 0.00194744157415097 0.0143746614709215 0.989212671450188 0.666666666666667 30.4 30 4 blepharoptosis 0.0214158299816607 0.0908301399477937 0.989212671450188 0.666666666666667 30.4 30 4 eye inflammation 0.0214158299816607 0.0908301399477937 0.989212671450188 0.666666666666667 30.4 30 4 abnormal thyroid cartilage morphology 0.0214158299816607 0.0908301399477937 0.989212671450188 0.666666666666667 30.4 30 4 abnormal Peyer's patch follicle morphology 0.0214158299816607 0.0908301399477937 0.989212671450188 0.666666666666667 30.4 30 4 acidosis 0.0214158299816607 0.0908301399477937 0.989212671450188 0.666666666666667 30.4 30 4 increased circulating renin level 0.0214158299816607 0.0908301399477937 0.989212671450188 0.666666666666667 30.4 30 4 abnormal body wall morphology 0.0214158299816607 0.0908301399477937 0.989212671450188 0.666666666666667 30.4 30 4 increased circulating glycerol level 0.0214158299816607 0.0908301399477937 0.989212671450188 0.666666666666667 30.4 30 4 absent ureter 0.0214158299816607 0.0908301399477937 0.989212671450188 0.666666666666667 30.4 30 4 abnormal neutrophil morphology 0.0214158299816607 0.0908301399477937 0.989212671450188 0.666666666666667 30.4 30 4 abnormal glycogen homeostasis 0.0214158299816607 0.0908301399477937 0.989212671450188 0.666666666666667 30.4 30 4 abnormal pregnancy 0.0214158299816607 0.0908301399477937 0.989212671450188 0.666666666666667 30.4 30 4 increased gastrointestinal tumor incidence 0.0214158299816607 0.0908301399477937 0.989212671450188 0.666666666666667 30.4 30 4 increased effector memory CD4-positive, alpha-beta T cell number 0.0214158299816607 0.0908301399477937 0.989212671450188 0.666666666666667 30.4 30 4 abnormal aerobic respiration 0.0214158299816607 0.0908301399477937 0.989212671450188 0.666666666666667 30.4 30 4 abnormal metanephric mesenchyme morphology 0.0214158299816607 0.0908301399477937 0.989212671450188 0.666666666666667 30.4 30 4 abnormal head movements 0.102256096445196 0.268792235644317 0.989212671450188 0.666666666666667 30.4 30 4 deformed nails 0.102256096445196 0.268792235644317 0.989212671450188 0.666666666666667 30.4 30 4 thick tail 0.102256096445196 0.268792235644317 0.989212671450188 0.666666666666667 30.4 30 4 wavy vibrissae 0.102256096445196 0.268792235644317 0.989212671450188 0.666666666666667 30.4 30 4 long gestation period 0.102256096445196 0.268792235644317 0.989212671450188 0.666666666666667 30.4 30 4 pancreas cysts 0.102256096445196 0.268792235644317 0.989212671450188 0.666666666666667 30.4 30 4 abnormal ovary physiology 0.102256096445196 0.268792235644317 0.989212671450188 0.666666666666667 30.4 30 4 abnormal proprioceptive neuron morphology 0.102256096445196 0.268792235644317 0.989212671450188 0.666666666666667 30.4 30 4 decreased vestibular hair cell number 0.102256096445196 0.268792235644317 0.989212671450188 0.666666666666667 30.4 30 4 small scapula 0.102256096445196 0.268792235644317 0.989212671450188 0.666666666666667 30.4 30 4 decreased thyroid-stimulating hormone level 0.102256096445196 0.268792235644317 0.989212671450188 0.666666666666667 30.4 30 4 increased circulating progesterone level 0.102256096445196 0.268792235644317 0.989212671450188 0.666666666666667 30.4 30 4 absent adrenal gland 0.102256096445196 0.268792235644317 0.989212671450188 0.666666666666667 30.4 30 4 abnormal retinal development 0.102256096445196 0.268792235644317 0.989212671450188 0.666666666666667 30.4 30 4 abnormal liver vasculature morphology 0.102256096445196 0.268792235644317 0.989212671450188 0.666666666666667 30.4 30 4 multiflagellated sperm 0.102256096445196 0.268792235644317 0.989212671450188 0.666666666666667 30.4 30 4 eye opacity 0.102256096445196 0.268792235644317 0.989212671450188 0.666666666666667 30.4 30 4 axonal spheroids 0.102256096445196 0.268792235644317 0.989212671450188 0.666666666666667 30.4 30 4 abnormal incisor color 0.102256096445196 0.268792235644317 0.989212671450188 0.666666666666667 30.4 30 4 abnormal telomere morphology 0.102256096445196 0.268792235644317 0.989212671450188 0.666666666666667 30.4 30 4 retropulsion 0.102256096445196 0.268792235644317 0.989212671450188 0.666666666666667 30.4 30 4 shortened ST segment 0.102256096445196 0.268792235644317 0.989212671450188 0.666666666666667 30.4 30 4 abnormal oxidative phosphorylation 0.102256096445196 0.268792235644317 0.989212671450188 0.666666666666667 30.4 30 4 decreased pancreatic beta cell proliferation 0.102256096445196 0.268792235644317 0.989212671450188 0.666666666666667 30.4 30 4 increased myeloid cell number 0.102256096445196 0.268792235644317 0.989212671450188 0.666666666666667 30.4 30 4 abnormal coronary sinus connection 0.102256096445196 0.268792235644317 0.989212671450188 0.666666666666667 30.4 30 4 abnormal heart morphology 3.98667115007434e-16 6.01020877927874e-14 0.989212671450188 0.666666666666667 30.4 30 4 decreased spleen weight 8.27451764494238e-06 0.000149151178563726 0.989212671450188 0.666666666666667 30.4 30 4 absent mesoderm 3.18122327668611e-05 0.000475272846892294 0.989212671450188 0.666666666666667 30.4 30 4 abnormal cell adhesion 7.84684879539844e-05 0.00103002830493687 0.989212671450188 0.666666666666667 30.4 30 4 abnormal neuronal precursor proliferation 7.84684879539844e-05 0.00103002830493687 0.989212671450188 0.666666666666667 30.4 30 4 abnormal metabolism 0.000307081040057214 0.0032468569836217 0.989212671450188 0.666666666666667 30.4 30 4 lethality at weaning, complete penetrance 0.000307081040057214 0.0032468569836217 0.989212671450188 0.666666666666667 30.4 30 4 abnormal cartilage morphology 0.000485583228411241 0.00474612291030633 0.989212671450188 0.666666666666667 30.4 30 4 disheveled coat 0.000485583228411241 0.00474612291030633 0.989212671450188 0.666666666666667 30.4 30 4 abnormal cytotoxic T cell physiology 0.000485583228411241 0.00474612291030633 0.989212671450188 0.666666666666667 30.4 30 4 gastrointestinal hemorrhage 0.00311316668598722 0.020986455640632 0.989212671450188 0.666666666666667 30.4 30 4 enhanced paired-pulse facilitation 0.00311316668598722 0.020986455640632 0.989212671450188 0.666666666666667 30.4 30 4 rectal prolapse 0.00499710397933322 0.0303919221236953 0.989212671450188 0.666666666666667 30.4 30 4 thin epidermis 0.00499710397933322 0.0303919221236953 0.989212671450188 0.666666666666667 30.4 30 4 abnormal fetal cardiomyocyte proliferation 0.00499710397933322 0.0303919221236953 0.989212671450188 0.666666666666667 30.4 30 4 abnormal digestive system morphology 0.00806137792175019 0.0443153095698422 0.989212671450188 0.666666666666667 30.4 30 4 abnormal foregut morphology 0.00806137792175019 0.0443153095698422 0.989212671450188 0.666666666666667 30.4 30 4 decreased metastatic potential 0.00806137792175019 0.0443153095698422 0.989212671450188 0.666666666666667 30.4 30 4 increased stereotypic behavior 0.00806137792175019 0.0443153095698422 0.989212671450188 0.666666666666667 30.4 30 4 abnormal impulse conducting system conduction 0.00806137792175019 0.0443153095698422 0.989212671450188 0.666666666666667 30.4 30 4 prolonged QT interval 0.00806137792175019 0.0443153095698422 0.989212671450188 0.666666666666667 30.4 30 4 decreased fatty acid level 0.00806137792175019 0.0443153095698422 0.989212671450188 0.666666666666667 30.4 30 4 abnormal inner cell mass apoptosis 0.00806137792175019 0.0443153095698422 0.989212671450188 0.666666666666667 30.4 30 4 abnormal scapula morphology 0.0130864221942793 0.0620799491921768 0.989212671450188 0.666666666666667 30.4 30 4 complete atrioventricular septal defect 0.0130864221942793 0.0620799491921768 0.989212671450188 0.666666666666667 30.4 30 4 increased muscle cell glucose uptake 0.0130864221942793 0.0620799491921768 0.989212671450188 0.666666666666667 30.4 30 4 absent incisors 0.035426633977331 0.130941682048456 0.989212671450188 0.666666666666667 30.4 30 4 abnormal apical ectodermal ridge morphology 0.035426633977331 0.130941682048456 0.989212671450188 0.666666666666667 30.4 30 4 increased airway responsiveness 0.035426633977331 0.130941682048456 0.989212671450188 0.666666666666667 30.4 30 4 dilated ureter 0.035426633977331 0.130941682048456 0.989212671450188 0.666666666666667 30.4 30 4 abnormal glial cell morphology 0.035426633977331 0.130941682048456 0.989212671450188 0.666666666666667 30.4 30 4 abnormal ear development 0.035426633977331 0.130941682048456 0.989212671450188 0.666666666666667 30.4 30 4 absent chorion 0.035426633977331 0.130941682048456 0.989212671450188 0.666666666666667 30.4 30 4 decreased brown adipose tissue mass 0.035426633977331 0.130941682048456 0.989212671450188 0.666666666666667 30.4 30 4 abnormal adipose tissue distribution 0.0594993433791487 0.192390304732296 0.989212671450188 0.666666666666667 30.4 30 4 abnormal esophagus morphology 0.0594993433791487 0.192390304732296 0.989212671450188 0.666666666666667 30.4 30 4 amyloidosis 0.0594993433791487 0.192390304732296 0.989212671450188 0.666666666666667 30.4 30 4 abnormal mating frequency 0.0594993433791487 0.192390304732296 0.989212671450188 0.666666666666667 30.4 30 4 interstitial pneumonia 0.0594993433791487 0.192390304732296 0.989212671450188 0.666666666666667 30.4 30 4 increased papilloma incidence 0.0594993433791487 0.192390304732296 0.989212671450188 0.666666666666667 30.4 30 4 increased growth rate 0.0594993433791487 0.192390304732296 0.989212671450188 0.666666666666667 30.4 30 4 small thyroid gland 0.0594993433791487 0.192390304732296 0.989212671450188 0.666666666666667 30.4 30 4 decreased left ventricle systolic pressure 0.0594993433791487 0.192390304732296 0.989212671450188 0.666666666666667 30.4 30 4 increased hepatocyte proliferation 0.0594993433791487 0.192390304732296 0.989212671450188 0.666666666666667 30.4 30 4 abnormal B cell proliferation 0.0594993433791487 0.192390304732296 0.989212671450188 0.666666666666667 30.4 30 4 hematuria 0.0594993433791487 0.192390304732296 0.989212671450188 0.666666666666667 30.4 30 4 abnormal patella morphology 0.0594993433791487 0.192390304732296 0.989212671450188 0.666666666666667 30.4 30 4 abnormal thymus corticomedullary boundary morphology 0.0594993433791487 0.192390304732296 0.989212671450188 0.666666666666667 30.4 30 4 increased macrophage cell number 4.99336658425664e-05 0.000705738601041954 0.989212671450188 0.666666666666667 30.4 30 4 abnormal cranium morphology 8.1719084868813e-10 3.53523867149865e-08 0.985521579392538 0.664179104477612 30.4 30 4 embryonic lethality before implantation, complete penetrance 3.05728669222041e-09 1.20714295982512e-07 0.985255820764387 0.664 30.4 30 4 anemia 1.52937464849112e-14 1.61885933537092e-12 0.984524459737154 0.663507109004739 30.4 30 4 increased inflammatory response 2.52299923663333e-07 6.64122814933905e-06 0.984006288968871 0.663157894736842 30.4 30 4 pallor 2.92422536532873e-12 2.04901706936766e-10 0.98356002761333 0.662857142857143 30.4 30 4 abnormal lipid level 1.48842658177051e-06 3.23359049969793e-05 0.983253558971572 0.662650602409639 30.4 30 4 abnormal cytokine secretion 6.28783156491902e-11 3.4757735594969e-09 0.982789212544667 0.662337662337662 30.4 30 4 abnormal vitelline vasculature morphology 1.90512345606331e-08 6.53654427166549e-07 0.98061082213323 0.660869565217391 30.4 30 4 increased bone mineral content 4.60185497028211e-08 1.4220017687673e-06 0.980137325840553 0.660550458715596 30.4 30 4 abnormal circulating protein level 0.000207281473836223 0.00238709567670187 0.979320544735686 0.66 30.4 30 4 pulmonary hypoplasia 0.000326834091166192 0.00343037891044685 0.978689132392207 0.659574468085106 30.4 30 4 abnormal locomotor activation 6.53306383958829e-07 1.56259579817076e-05 0.978342202533153 0.659340659340659 30.4 30 4 abnormal astrocyte morphology 0.000516225616161368 0.00497717527209846 0.977971618365527 0.659090909090909 30.4 30 4 omphalocele 0.000516225616161368 0.00497717527209846 0.977971618365527 0.659090909090909 30.4 30 4 abnormal amino acid level 0.000516225616161368 0.00497717527209846 0.977971618365527 0.659090909090909 30.4 30 4 decreased blood urea nitrogen level 0.000516225616161368 0.00497717527209846 0.977971618365527 0.659090909090909 30.4 30 4 lethality, incomplete penetrance 0.000516225616161368 0.00497717527209846 0.977971618365527 0.659090909090909 30.4 30 4 embryonic lethality, incomplete penetrance 0.000516225616161368 0.00497717527209846 0.977971618365527 0.659090909090909 30.4 30 4 respiratory distress 8.02462625225423e-12 5.39493454121146e-10 0.977776686809145 0.658959537572254 30.4 30 4 abnormal mammary gland development 0.000816960016817748 0.00715559169659912 0.977149102286161 0.658536585365854 30.4 30 4 liver fibrosis 0.000816960016817748 0.00715559169659912 0.977149102286161 0.658536585365854 30.4 30 4 increased tumor growth/size 0.000816960016817748 0.00715559169659912 0.977149102286161 0.658536585365854 30.4 30 4 abnormal frontal bone morphology 0.00129579750358886 0.0106379415517403 0.976196715246896 0.657894736842105 30.4 30 4 increased bone marrow cell number 0.00129579750358886 0.0106379415517403 0.976196715246896 0.657894736842105 30.4 30 4 incomplete somite formation 0.00129579750358886 0.0106379415517403 0.976196715246896 0.657894736842105 30.4 30 4 hypoactivity 8.14135592200504e-24 3.11563428553654e-21 0.976093139998594 0.657824933687003 30.4 30 4 decreased hematocrit 4.1404942312402e-10 1.99989891266214e-08 0.975661812937172 0.657534246575342 30.4 30 4 decreased bone marrow cell number 9.41906001401444e-06 0.000167956356880724 0.975661812937172 0.657534246575342 30.4 30 4 increased insulin sensitivity 6.42016494082568e-10 2.90366550732798e-08 0.975377529192143 0.657342657342657 30.4 30 4 weight loss 8.54438275922894e-12 5.66777389695519e-10 0.975081061858042 0.657142857142857 30.4 30 4 spleen hypoplasia 1.1841414898909e-07 3.3473791199737e-06 0.975081061858042 0.657142857142857 30.4 30 4 abnormal intestinal goblet cell morphology 0.00206064824537027 0.0149794691193543 0.975081061858042 0.657142857142857 30.4 30 4 increased red blood cell distribution width 0.00206064824537027 0.0149794691193543 0.975081061858042 0.657142857142857 30.4 30 4 internal hemorrhage 2.303779342921e-05 0.000359288471192225 0.974448303219588 0.656716417910448 30.4 30 4 decreased circulating serum albumin level 2.86438378018788e-07 7.50016279286037e-06 0.974224600670639 0.656565656565657 30.4 30 4 abnormal vertebral body morphology 0.00328696757697674 0.0219021677261951 0.973756223458779 0.65625 30.4 30 4 scoliosis 0.00328696757697674 0.0219021677261951 0.973756223458779 0.65625 30.4 30 4 increased circulating follicle stimulating hormone level 0.00328696757697674 0.0219021677261951 0.973756223458779 0.65625 30.4 30 4 abnormal lumbar vertebrae morphology 0.00328696757697674 0.0219021677261951 0.973756223458779 0.65625 30.4 30 4 bradykinesia 0.00328696757697674 0.0219021677261951 0.973756223458779 0.65625 30.4 30 4 decreased body weight 6.2199894834759e-75 3.09444476802926e-71 0.973231852848408 0.655896607431341 30.4 30 4 abnormal NK cell physiology 5.65318789201201e-05 0.000790017128167408 0.972996070278873 0.655737704918033 30.4 30 4 thin ventricular wall 1.08039435389432e-06 2.4431645048292e-05 0.972725793592685 0.655555555555556 30.4 30 4 abnormal lung morphology 2.15606600756192e-08 7.29689005960583e-07 0.972587248400605 0.65546218487395 30.4 30 4 abnormal spermiogenesis 8.86835289021782e-05 0.00113419166140961 0.972157280563116 0.655172413793103 30.4 30 4 lordosis 0.00526210905534706 0.0314651352768649 0.972157280563116 0.655172413793103 30.4 30 4 decreased granulocyte number 0.00526210905534706 0.0314651352768649 0.972157280563116 0.655172413793103 30.4 30 4 abnormal spinal nerve morphology 0.00526210905534706 0.0314651352768649 0.972157280563116 0.655172413793103 30.4 30 4 abnormal CD8-positive, alpha-beta T cell physiology 0.00526210905534706 0.0314651352768649 0.972157280563116 0.655172413793103 30.4 30 4 increased spleen weight 5.19941578432636e-08 1.57726180042827e-06 0.971704482574963 0.654867256637168 30.4 30 4 prenatal lethality, incomplete penetrance 4.87136439760791e-19 1.0536972990478e-16 0.971315731670662 0.654605263157895 30.4 30 4 abnormal skeleton development 4.09027703058727e-06 8.07505088379828e-05 0.970893918275184 0.654320987654321 30.4 30 4 decreased bone mineral density 8.6735161987226e-17 1.43835810295483e-14 0.970618448302628 0.654135338345865 30.4 30 4 absent gastric milk in neonates 6.38123881106236e-06 0.000119798728622775 0.970189350845377 0.653846153846154 30.4 30 4 abnormal nasal bone morphology 0.00846097862042342 0.0459534592102691 0.970189350845377 0.653846153846154 30.4 30 4 abnormal xiphoid process morphology 0.00846097862042342 0.0459534592102691 0.970189350845377 0.653846153846154 30.4 30 4 abnormal leukocyte cell number 0.00846097862042342 0.0459534592102691 0.970189350845377 0.653846153846154 30.4 30 4 increased leukemia incidence 0.00846097862042342 0.0459534592102691 0.970189350845377 0.653846153846154 30.4 30 4 abnormal epidermis stratum corneum morphology 0.000344796627232857 0.00355391575001094 0.969024657747123 0.653061224489796 30.4 30 4 abnormal respiratory system physiology 0.000344796627232857 0.00355391575001094 0.969024657747123 0.653061224489796 30.4 30 4 abnormal craniofacial development 0.000344796627232857 0.00355391575001094 0.969024657747123 0.653061224489796 30.4 30 4 abnormal bone structure 1.77276427536863e-12 1.31634362238193e-10 0.968710854425314 0.652849740932642 30.4 30 4 enlarged spleen 7.0836750839837e-18 1.26066270188771e-15 0.968604074128309 0.652777777777778 30.4 30 4 abnormal digit morphology 1.55583518547922e-05 0.000252950328358142 0.968604074128309 0.652777777777778 30.4 30 4 decreased birth weight 7.33544793148804e-07 1.7295665146518e-05 0.968387141524921 0.652631578947368 30.4 30 4 abnormal allantois morphology 0.000543712534212068 0.00520186511097123 0.967708048157793 0.652173913043478 30.4 30 4 delayed wound healing 0.000543712534212068 0.00520186511097123 0.967708048157793 0.652173913043478 30.4 30 4 abnormal circulating insulin level 0.0136776299646029 0.0642147270504766 0.967708048157793 0.652173913043478 30.4 30 4 abnormal postnatal growth 0.0136776299646029 0.0642147270504766 0.967708048157793 0.652173913043478 30.4 30 4 conjunctivitis 0.0136776299646029 0.0642147270504766 0.967708048157793 0.652173913043478 30.4 30 4 abnormal nasal cavity morphology 0.0136776299646029 0.0642147270504766 0.967708048157793 0.652173913043478 30.4 30 4 abnormal cochlear ganglion morphology 0.0136776299646029 0.0642147270504766 0.967708048157793 0.652173913043478 30.4 30 4 abnormal corneal stroma morphology 0.0136776299646029 0.0642147270504766 0.967708048157793 0.652173913043478 30.4 30 4 abnormal hepatocyte physiology 0.0136776299646029 0.0642147270504766 0.967708048157793 0.652173913043478 30.4 30 4 decreased effector memory CD8-positive, alpha-beta T cell number 0.0136776299646029 0.0642147270504766 0.967708048157793 0.652173913043478 30.4 30 4 abnormal skeleton morphology 5.49609620285935e-08 1.65338809673673e-06 0.967708048157793 0.652173913043478 30.4 30 4 abnormal sternum morphology 2.43172457457952e-05 0.000374545812957682 0.967708048157793 0.652173913043478 30.4 30 4 increased lymphocyte cell number 2.43172457457952e-05 0.000374545812957682 0.967708048157793 0.652173913043478 30.4 30 4 increased oxygen consumption 2.76720285932936e-06 5.62406391067607e-05 0.966207725602509 0.651162790697674 30.4 30 4 abnormal left-right axis patterning 0.000858866730204335 0.00748312081044932 0.966207725602509 0.651162790697674 30.4 30 4 increased circulating aspartate transaminase level 5.95375798926862e-05 0.000827372793201436 0.965659988796612 0.650793650793651 30.4 30 4 neonatal lethality, incomplete penetrance 5.85553817643102e-16 8.56803012580715e-14 0.964482354663933 0.65 30.4 30 4 enlarged liver 4.96875416581794e-07 1.23597759874721e-05 0.964482354663933 0.65 30.4 30 4 abnormal dopamine level 0.0222602418956745 0.0935343778977879 0.964482354663933 0.65 30.4 30 4 abnormal hair texture 0.0222602418956745 0.0935343778977879 0.964482354663933 0.65 30.4 30 4 abnormal Peyer's patch T cell area morphology 0.0222602418956745 0.0935343778977879 0.964482354663933 0.65 30.4 30 4 decreased myocardial infarction size 0.0222602418956745 0.0935343778977879 0.964482354663933 0.65 30.4 30 4 decreased total body fat amount 4.93785364498051e-20 1.16980104208467e-17 0.964038097476156 0.649700598802395 30.4 30 4 impaired glucose tolerance 3.34418057273472e-15 4.0578776461842e-13 0.96328572643234 0.649193548387097 30.4 30 4 cleft secondary palate 1.20090462217192e-06 2.67914820417279e-05 0.962903823805236 0.648936170212766 30.4 30 4 abnormal small intestine morphology 0.000229643273639508 0.00260244939944545 0.961734541687683 0.648148148148148 30.4 30 4 neurodegeneration 0.000229643273639508 0.00260244939944545 0.961734541687683 0.648148148148148 30.4 30 4 decreased tumor growth/size 0.000229643273639508 0.00260244939944545 0.961734541687683 0.648148148148148 30.4 30 4 axon degeneration 0.000229643273639508 0.00260244939944545 0.961734541687683 0.648148148148148 30.4 30 4 decreased platelet aggregation 0.000229643273639508 0.00260244939944545 0.961734541687683 0.648148148148148 30.4 30 4 increased heart weight 4.61017943006854e-09 1.77795679570473e-07 0.96074611975378 0.647482014388489 30.4 30 4 increased lung adenocarcinoma incidence 0.000360937627702393 0.00371005102855249 0.960118181113418 0.647058823529412 30.4 30 4 lung hemorrhage 0.00342968079035797 0.0227502159093745 0.960118181113418 0.647058823529412 30.4 30 4 abnormal endoderm development 0.00342968079035797 0.0227502159093745 0.960118181113418 0.647058823529412 30.4 30 4 decreased vasoconstriction 0.0365461258256977 0.134281370740654 0.960118181113418 0.647058823529412 30.4 30 4 abnormal duodenum morphology 0.0365461258256977 0.134281370740654 0.960118181113418 0.647058823529412 30.4 30 4 abnormal electroretinogram waveform feature 0.0365461258256977 0.134281370740654 0.960118181113418 0.647058823529412 30.4 30 4 decreased body fat mass 0.0365461258256977 0.134281370740654 0.960118181113418 0.647058823529412 30.4 30 4 abnormal spermatogenesis 1.83334353609002e-11 1.15454229013264e-09 0.959643814423144 0.646739130434783 30.4 30 4 abnormal lymph node morphology 0.000568042533517278 0.00541381533380931 0.958299775467369 0.645833333333333 30.4 30 4 abnormal placenta morphology 1.09707057620419e-05 0.000189511323493606 0.957908472986574 0.645569620253165 30.4 30 4 hypoglycemia 1.95544124361417e-06 4.12216957075444e-05 0.957302585274375 0.645161290322581 30.4 30 4 increased eosinophil cell number 9.75090293883658e-05 0.00124068394170619 0.957302585274375 0.645161290322581 30.4 30 4 decreased thymus weight 0.00547154266369032 0.0323673302638042 0.957302585274375 0.645161290322581 30.4 30 4 pale kidney 0.00547154266369032 0.0323673302638042 0.957302585274375 0.645161290322581 30.4 30 4 abnormal T cell proliferation 0.00547154266369032 0.0323673302638042 0.957302585274375 0.645161290322581 30.4 30 4 abnormal podocyte morphology 0.00547154266369032 0.0323673302638042 0.957302585274375 0.645161290322581 30.4 30 4 small cranium 0.00547154266369032 0.0323673302638042 0.957302585274375 0.645161290322581 30.4 30 4 abnormal intestine physiology 0.00547154266369032 0.0323673302638042 0.957302585274375 0.645161290322581 30.4 30 4 small testis 3.13330390351572e-16 4.87130841249709e-14 0.956955736511595 0.644927536231884 30.4 30 4 abnormal axial skeleton morphology 1.70966998793529e-05 0.000275262400970164 0.956672780941958 0.644736842105263 30.4 30 4 cachexia 5.45534093721265e-07 1.32391810549429e-05 0.955921860391768 0.644230769230769 30.4 30 4 abnormal motor capabilities/coordination/movement 1.79100229219588e-08 6.23093454802414e-07 0.955489512196204 0.643939393939394 30.4 30 4 decreased percent body fat/body weight 2.66563024900443e-05 0.00040804647657837 0.955335525167647 0.643835616438356 30.4 30 4 abnormal T cell differentiation 8.46508133584846e-07 1.96793362831056e-05 0.954933024419736 0.643564356435644 30.4 30 4 abnormal seminal vesicle morphology 0.000239233541892673 0.00265666712258047 0.953883647469824 0.642857142857143 30.4 30 4 abnormal circulating cholesterol level 0.00876076824884386 0.046590318736362 0.953883647469824 0.642857142857143 30.4 30 4 abnormal jaw morphology 0.00876076824884386 0.046590318736362 0.953883647469824 0.642857142857143 30.4 30 4 lymphoid hyperplasia 0.00876076824884386 0.046590318736362 0.953883647469824 0.642857142857143 30.4 30 4 abnormal ovulation 0.00876076824884386 0.046590318736362 0.953883647469824 0.642857142857143 30.4 30 4 corneal vascularization 0.00876076824884386 0.046590318736362 0.953883647469824 0.642857142857143 30.4 30 4 prolonged QRS complex duration 0.00876076824884386 0.046590318736362 0.953883647469824 0.642857142857143 30.4 30 4 abnormal adrenal gland secretion 0.060709623624062 0.192390304732296 0.953883647469824 0.642857142857143 30.4 30 4 abnormal spleen periarteriolar lymphoid sheath morphology 0.060709623624062 0.192390304732296 0.953883647469824 0.642857142857143 30.4 30 4 increased lactate dehydrogenase level 0.060709623624062 0.192390304732296 0.953883647469824 0.642857142857143 30.4 30 4 absent otoliths 0.060709623624062 0.192390304732296 0.953883647469824 0.642857142857143 30.4 30 4 amyloid beta deposits 0.060709623624062 0.192390304732296 0.953883647469824 0.642857142857143 30.4 30 4 abnormal ventral body wall morphology 0.060709623624062 0.192390304732296 0.953883647469824 0.642857142857143 30.4 30 4 failure of zygotic cell division 0.060709623624062 0.192390304732296 0.953883647469824 0.642857142857143 30.4 30 4 abnormal positive T cell selection 0.060709623624062 0.192390304732296 0.953883647469824 0.642857142857143 30.4 30 4 decreased cornea thickness 0.060709623624062 0.192390304732296 0.953883647469824 0.642857142857143 30.4 30 4 increased stomach tumor incidence 0.060709623624062 0.192390304732296 0.953883647469824 0.642857142857143 30.4 30 4 abnormal renal tubule epithelial cell primary cilium morphology 0.060709623624062 0.192390304732296 0.953883647469824 0.642857142857143 30.4 30 4 arrest of spermatogenesis 7.34960556094781e-06 0.000134427528182777 0.953883647469824 0.642857142857143 30.4 30 4 abnormal spleen white pulp morphology 0.00141343823594947 0.0112509683581578 0.953883647469824 0.642857142857143 30.4 30 4 premature death 8.22655677126948e-47 6.82118665617761e-44 0.953021963958108 0.642276422764228 30.4 30 4 abnormal coat/ hair morphology 0.000375259473812024 0.00384794102382607 0.951883891395464 0.641509433962264 30.4 30 4 increased circulating alanine transaminase level 1.77962225282034e-05 0.000284682337870777 0.951166030240565 0.641025641025641 30.4 30 4 abnormal heart looping 0.00223564164443462 0.0160727126893963 0.951166030240565 0.641025641025641 30.4 30 4 small lens 0.00223564164443462 0.0160727126893963 0.951166030240565 0.641025641025641 30.4 30 4 postnatal lethality, incomplete penetrance 7.05412548128532e-31 3.50942742693945e-28 0.95089809614754 0.640845070422535 30.4 30 4 abnormal muscle physiology 4.91754119042069e-06 9.55654977435271e-05 0.950311049539226 0.640449438202247 30.4 30 4 abnormal behavior 8.85823285786012e-16 1.19107320183389e-13 0.950071162867626 0.640287769784173 30.4 30 4 abnormal thyroid gland morphology 0.0140887153157041 0.0657517436169118 0.94964416459218 0.64 30.4 30 4 increased liver glycogen level 0.0140887153157041 0.0657517436169118 0.94964416459218 0.64 30.4 30 4 decreased IgG level 3.81626185439958e-07 9.68668506410098e-06 0.949109455040045 0.63963963963964 30.4 30 4 increased circulating creatinine level 7.63878958971319e-06 0.000139205048383967 0.94895401621675 0.63953488372093 30.4 30 4 abnormal maternal nurturing 0.000158419627382285 0.00192431243020913 0.948671168521901 0.639344262295082 30.4 30 4 abnormal long bone morphology 0.000158419627382285 0.00192431243020913 0.948671168521901 0.639344262295082 30.4 30 4 reduced long term depression 0.00354373550177712 0.0233511047964784 0.94799547680643 0.638888888888889 30.4 30 4 abnormal limb bone morphology 0.00354373550177712 0.0233511047964784 0.94799547680643 0.638888888888889 30.4 30 4 short radius 0.00354373550177712 0.0233511047964784 0.94799547680643 0.638888888888889 30.4 30 4 abnormal retinal blood vessel morphology 0.00354373550177712 0.0233511047964784 0.94799547680643 0.638888888888889 30.4 30 4 ataxia 9.93968988178725e-12 6.42207235868721e-10 0.947587385770353 0.638613861386139 30.4 30 4 hemorrhage 2.27050474368353e-13 1.91453577963145e-11 0.947118515218265 0.638297872340426 30.4 30 4 abnormal tibia morphology 0.000926439198410671 0.00797410901746209 0.947118515218265 0.638297872340426 30.4 30 4 increased cellular sensitivity to gamma-irradiation 0.000926439198410671 0.00797410901746209 0.947118515218265 0.638297872340426 30.4 30 4 abnormal T-helper 1 physiology 0.000926439198410671 0.00797410901746209 0.947118515218265 0.638297872340426 30.4 30 4 abnormal embryonic neuroepithelium morphology 0.000247761158316438 0.00272701717394752 0.946574194232507 0.637931034482759 30.4 30 4 abnormal enzyme/coenzyme level 0.000247761158316438 0.00272701717394752 0.946574194232507 0.637931034482759 30.4 30 4 kinked tail 1.41734954596308e-06 3.09268157507296e-05 0.945570935945033 0.637254901960784 30.4 30 4 perinatal lethality, incomplete penetrance 8.30148343245623e-13 6.4531062619484e-11 0.945442199262127 0.63716814159292 30.4 30 4 decreased body size 1.75505254194255e-41 1.24734091373774e-38 0.944586535896044 0.636591478696742 30.4 30 4 abnormal joint morphology 0.000387790979577092 0.00393726555795109 0.944248459111543 0.636363636363636 30.4 30 4 enlarged pericardium 0.00563113808192186 0.0331145531413254 0.944248459111543 0.636363636363636 30.4 30 4 abnormal middle ear ossicle morphology 0.00563113808192186 0.0331145531413254 0.944248459111543 0.636363636363636 30.4 30 4 myeloid hyperplasia 0.00563113808192186 0.0331145531413254 0.944248459111543 0.636363636363636 30.4 30 4 abnormal motor coordination/ balance 2.19530470576148e-06 4.56972423061228e-05 0.944248459111543 0.636363636363636 30.4 30 4 abnormal chorion morphology 0.0227784559609677 0.0949897891079752 0.944248459111543 0.636363636363636 30.4 30 4 abnormal cochlear sensory epithelium morphology 0.0227784559609677 0.0949897891079752 0.944248459111543 0.636363636363636 30.4 30 4 abnormal limb posture 0.0227784559609677 0.0949897891079752 0.944248459111543 0.636363636363636 30.4 30 4 increased circulating creatine kinase level 0.0227784559609677 0.0949897891079752 0.944248459111543 0.636363636363636 30.4 30 4 abnormal awl hair morphology 0.102546263970435 0.268792235644317 0.944248459111543 0.636363636363636 30.4 30 4 abnormal hemoglobin 0.102546263970435 0.268792235644317 0.944248459111543 0.636363636363636 30.4 30 4 abnormal bronchiole morphology 0.102546263970435 0.268792235644317 0.944248459111543 0.636363636363636 30.4 30 4 retinal detachment 0.102546263970435 0.268792235644317 0.944248459111543 0.636363636363636 30.4 30 4 allodynia 0.102546263970435 0.268792235644317 0.944248459111543 0.636363636363636 30.4 30 4 abnormal ureter development 0.102546263970435 0.268792235644317 0.944248459111543 0.636363636363636 30.4 30 4 abnormal crista ampullaris neuroepithelium morphology 0.102546263970435 0.268792235644317 0.944248459111543 0.636363636363636 30.4 30 4 abnormal spinal cord ventral horn morphology 0.102546263970435 0.268792235644317 0.944248459111543 0.636363636363636 30.4 30 4 abnormal superovulation 0.102546263970435 0.268792235644317 0.944248459111543 0.636363636363636 30.4 30 4 enhanced behavioral response to addictive substance 0.102546263970435 0.268792235644317 0.944248459111543 0.636363636363636 30.4 30 4 increased number of Howell-Jolly bodies 0.102546263970435 0.268792235644317 0.944248459111543 0.636363636363636 30.4 30 4 increased subcutaneous adipose tissue amount 0.102546263970435 0.268792235644317 0.944248459111543 0.636363636363636 30.4 30 4 decreased core body temperature 0.102546263970435 0.268792235644317 0.944248459111543 0.636363636363636 30.4 30 4 decreased embryonic cilium length 0.102546263970435 0.268792235644317 0.944248459111543 0.636363636363636 30.4 30 4 cyanosis 5.80750928184253e-11 3.28322257695075e-09 0.94284332747596 0.635416666666667 30.4 30 4 increased granulocyte number 4.45970647002506e-05 0.000641243921629325 0.942425585638355 0.635135135135135 30.4 30 4 abnormal intestine morphology 4.45970647002506e-05 0.000641243921629325 0.942425585638355 0.635135135135135 30.4 30 4 decreased leukocyte cell number 3.22528561094317e-08 1.0285766611822e-06 0.942279223534668 0.635036496350365 30.4 30 4 short ulna 0.00229953568427963 0.0164607050781167 0.940958394794081 0.634146341463415 30.4 30 4 increased bone trabecula number 0.00229953568427963 0.0164607050781167 0.940958394794081 0.634146341463415 30.4 30 4 decreased insulin secretion 8.16161788822365e-06 0.000147814280382174 0.939752037877678 0.633333333333333 30.4 30 4 abnormal kidney development 0.00025524205295564 0.00280315499658787 0.939752037877678 0.633333333333333 30.4 30 4 arrested T cell differentiation 0.00897391860242314 0.0467489476932515 0.939752037877678 0.633333333333333 30.4 30 4 abnormal microglial cell physiology 0.00897391860242314 0.0467489476932515 0.939752037877678 0.633333333333333 30.4 30 4 abnormal brain vasculature morphology 0.00897391860242314 0.0467489476932515 0.939752037877678 0.633333333333333 30.4 30 4 abnormal fat pad morphology 0.00897391860242314 0.0467489476932515 0.939752037877678 0.633333333333333 30.4 30 4 abnormal cellular respiration 0.00897391860242314 0.0467489476932515 0.939752037877678 0.633333333333333 30.4 30 4 decreased lymphocyte cell number 1.18419844244296e-07 3.3473791199737e-06 0.938979215478108 0.6328125 30.4 30 4 abnormal glucose homeostasis 3.36498872766754e-10 1.6740818920146e-08 0.937577944094272 0.631868131868132 30.4 30 4 kyphoscoliosis 0.0370754968459506 0.134635472123069 0.93714884663702 0.631578947368421 30.4 30 4 enlarged adrenal glands 0.0370754968459506 0.134635472123069 0.93714884663702 0.631578947368421 30.4 30 4 short vibrissae 0.0370754968459506 0.134635472123069 0.93714884663702 0.631578947368421 30.4 30 4 stereotypic behavior 0.0370754968459506 0.134635472123069 0.93714884663702 0.631578947368421 30.4 30 4 abnormal long term depression 0.0370754968459506 0.134635472123069 0.93714884663702 0.631578947368421 30.4 30 4 increased malignant tumor incidence 0.0370754968459506 0.134635472123069 0.93714884663702 0.631578947368421 30.4 30 4 decreased germ cell number 0.0370754968459506 0.134635472123069 0.93714884663702 0.631578947368421 30.4 30 4 maternal imprinting 0.0370754968459506 0.134635472123069 0.93714884663702 0.631578947368421 30.4 30 4 oliguria 0.0370754968459506 0.134635472123069 0.93714884663702 0.631578947368421 30.4 30 4 abnormal blastocyst morphology 0.0370754968459506 0.134635472123069 0.93714884663702 0.631578947368421 30.4 30 4 eyelids fail to open 0.0370754968459506 0.134635472123069 0.93714884663702 0.631578947368421 30.4 30 4 decreased circulating magnesium level 0.0370754968459506 0.134635472123069 0.93714884663702 0.631578947368421 30.4 30 4 increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 0.0370754968459506 0.134635472123069 0.93714884663702 0.631578947368421 30.4 30 4 alopecia 5.42567357616746e-06 0.000104219019464993 0.93714884663702 0.631578947368421 30.4 30 4 abnormal craniofacial bone morphology 0.000398581439501024 0.00403857975869163 0.93714884663702 0.631578947368421 30.4 30 4 abnormal forelimb morphology 0.00149506728729155 0.0118627747277121 0.935451113219199 0.630434782608696 30.4 30 4 abnormal sleep pattern 0.00149506728729155 0.0118627747277121 0.935451113219199 0.630434782608696 30.4 30 4 abnormal seminiferous tubule morphology 2.29238853498599e-08 7.70583308213197e-07 0.935009237398123 0.63013698630137 30.4 30 4 abnormal long bone epiphyseal plate proliferative zone 0.000622807014105301 0.00583515046172104 0.934256411925177 0.62962962962963 30.4 30 4 abnormal osteoblast physiology 0.000622807014105301 0.00583515046172104 0.934256411925177 0.62962962962963 30.4 30 4 abnormal skin appearance 0.0143495655102768 0.0665942988933088 0.934256411925177 0.62962962962963 30.4 30 4 decreased circulating fructosamine level 0.0143495655102768 0.0665942988933088 0.934256411925177 0.62962962962963 30.4 30 4 thick interventricular septum 0.0143495655102768 0.0665942988933088 0.934256411925177 0.62962962962963 30.4 30 4 enlarged heart 2.37578748174408e-12 1.68850610309668e-10 0.933782651067203 0.629310344827586 30.4 30 4 respiratory failure 1.53104693972e-08 5.47982627705541e-07 0.933528514448025 0.629139072847682 30.4 30 4 pericardial effusion 0.000261702815285016 0.00286777864767171 0.933370020642516 0.629032258064516 30.4 30 4 decreased IgM level 5.57134525073289e-06 0.000106538883364842 0.933123293172085 0.628865979381443 30.4 30 4 abnormal dermal layer morphology 0.00574650509726024 0.03359443344168 0.932686233081606 0.628571428571429 30.4 30 4 ovary cysts 0.00574650509726024 0.03359443344168 0.932686233081606 0.628571428571429 30.4 30 4 increased leukocyte cell number 3.62032914678032e-08 1.14600079003946e-06 0.931224342434142 0.627586206896552 30.4 30 4 impaired hematopoiesis 0.000973824446159341 0.00831007996508186 0.931023690776647 0.627450980392157 30.4 30 4 abnormal gastrulation 0.000973824446159341 0.00831007996508186 0.931023690776647 0.627450980392157 30.4 30 4 abnormal dendritic spine morphology 0.000973824446159341 0.00831007996508186 0.931023690776647 0.627450980392157 30.4 30 4 abnormal colon morphology 0.000407695611854169 0.00412253184750913 0.930530563821787 0.627118644067797 30.4 30 4 rib fusion 0.00017195714973446 0.00204661918643287 0.930155198527789 0.626865671641791 30.4 30 4 abnormal neurocranium morphology 7.29465354657652e-05 0.000975561865435972 0.929859911163177 0.626666666666667 30.4 30 4 small spleen 1.32968684927306e-05 0.000221986311246089 0.929425092406495 0.626373626373626 30.4 30 4 abnormal testis morphology 1.05768019727867e-06 2.4137426520465e-05 0.928999726231481 0.626086956521739 30.4 30 4 cochlear outer hair cell degeneration 0.000113070777652456 0.0014133847206557 0.927386879484551 0.625 30.4 30 4 lung inflammation 1.31430505902865e-07 3.67340880262221e-06 0.927386879484551 0.625 30.4 30 4 retinal degeneration 8.8008663208232e-06 0.00015749751779171 0.927386879484551 0.625 30.4 30 4 small kidney 2.05394687135589e-05 0.000323366635601125 0.927386879484551 0.625 30.4 30 4 increased sacral vertebrae number 0.00026717829816332 0.00291493866965464 0.927386879484551 0.625 30.4 30 4 abnormal intestinal epithelium morphology 0.00152376697323299 0.01201385212652 0.927386879484551 0.625 30.4 30 4 thymus atrophy 0.00152376697323299 0.01201385212652 0.927386879484551 0.625 30.4 30 4 polydipsia 0.00911250114154634 0.0473716752133679 0.927386879484551 0.625 30.4 30 4 abnormal nursing 0.023038050036024 0.0952637999917598 0.927386879484551 0.625 30.4 30 4 abnormal startle reflex 0.023038050036024 0.0952637999917598 0.927386879484551 0.625 30.4 30 4 hemolytic anemia 0.023038050036024 0.0952637999917598 0.927386879484551 0.625 30.4 30 4 abnormal primitive streak formation 0.023038050036024 0.0952637999917598 0.927386879484551 0.625 30.4 30 4 abnormal osteoblast morphology 0.023038050036024 0.0952637999917598 0.927386879484551 0.625 30.4 30 4 abnormal retinal ganglion layer morphology 0.023038050036024 0.0952637999917598 0.927386879484551 0.625 30.4 30 4 absent mandible 0.0608688119896751 0.192390304732296 0.927386879484551 0.625 30.4 30 4 abnormal pituitary gland morphology 0.0608688119896751 0.192390304732296 0.927386879484551 0.625 30.4 30 4 abnormal intestinal absorption 0.0608688119896751 0.192390304732296 0.927386879484551 0.625 30.4 30 4 abnormal olfaction 0.0608688119896751 0.192390304732296 0.927386879484551 0.625 30.4 30 4 impaired muscle relaxation 0.0608688119896751 0.192390304732296 0.927386879484551 0.625 30.4 30 4 decreased aggression towards mice 0.0608688119896751 0.192390304732296 0.927386879484551 0.625 30.4 30 4 bowed tibia 0.0608688119896751 0.192390304732296 0.927386879484551 0.625 30.4 30 4 decreased circulating prolactin level 0.0608688119896751 0.192390304732296 0.927386879484551 0.625 30.4 30 4 loose skin 0.0608688119896751 0.192390304732296 0.927386879484551 0.625 30.4 30 4 abnormal thoracic cage shape 0.0608688119896751 0.192390304732296 0.927386879484551 0.625 30.4 30 4 decreased skeletal muscle weight 0.0608688119896751 0.192390304732296 0.927386879484551 0.625 30.4 30 4 decreased fibroblast apoptosis 0.0608688119896751 0.192390304732296 0.927386879484551 0.625 30.4 30 4 abnormal exoccipital bone morphology 0.177703889836755 0.369226837775464 0.927386879484551 0.625 30.4 30 4 clubfoot 0.177703889836755 0.369226837775464 0.927386879484551 0.625 30.4 30 4 enlarged pituitary gland 0.177703889836755 0.369226837775464 0.927386879484551 0.625 30.4 30 4 dry eyes 0.177703889836755 0.369226837775464 0.927386879484551 0.625 30.4 30 4 poor grooming 0.177703889836755 0.369226837775464 0.927386879484551 0.625 30.4 30 4 abnormal urination 0.177703889836755 0.369226837775464 0.927386879484551 0.625 30.4 30 4 abnormal atrial thrombosis 0.177703889836755 0.369226837775464 0.927386879484551 0.625 30.4 30 4 short ureter 0.177703889836755 0.369226837775464 0.927386879484551 0.625 30.4 30 4 decreased aerobic running capacity 0.177703889836755 0.369226837775464 0.927386879484551 0.625 30.4 30 4 altered response to CNS ischemic injury 0.177703889836755 0.369226837775464 0.927386879484551 0.625 30.4 30 4 absent tympanic ring 0.177703889836755 0.369226837775464 0.927386879484551 0.625 30.4 30 4 abnormal neuron apoptosis 0.177703889836755 0.369226837775464 0.927386879484551 0.625 30.4 30 4 decreased susceptibility to age related obesity 0.177703889836755 0.369226837775464 0.927386879484551 0.625 30.4 30 4 loss of GABAergic neurons 0.177703889836755 0.369226837775464 0.927386879484551 0.625 30.4 30 4 colon polyps 0.177703889836755 0.369226837775464 0.927386879484551 0.625 30.4 30 4 increased cardiac output 0.177703889836755 0.369226837775464 0.927386879484551 0.625 30.4 30 4 hair follicle degeneration 0.177703889836755 0.369226837775464 0.927386879484551 0.625 30.4 30 4 pulmonary interstitial fibrosis 0.177703889836755 0.369226837775464 0.927386879484551 0.625 30.4 30 4 binucleate 0.177703889836755 0.369226837775464 0.927386879484551 0.625 30.4 30 4 abnormal skin development 0.177703889836755 0.369226837775464 0.927386879484551 0.625 30.4 30 4 tau protein deposits 0.177703889836755 0.369226837775464 0.927386879484551 0.625 30.4 30 4 small frontal bone 0.177703889836755 0.369226837775464 0.927386879484551 0.625 30.4 30 4 accumulation of giant lysosomes in kidney/renal tubule cells 0.177703889836755 0.369226837775464 0.927386879484551 0.625 30.4 30 4 abnormal choroid pigmentation 0.177703889836755 0.369226837775464 0.927386879484551 0.625 30.4 30 4 abnormal vertebral body development 0.177703889836755 0.369226837775464 0.927386879484551 0.625 30.4 30 4 ocular hypertension 0.177703889836755 0.369226837775464 0.927386879484551 0.625 30.4 30 4 abnormal ilium morphology 0.177703889836755 0.369226837775464 0.927386879484551 0.625 30.4 30 4 absent outer ear 0.177703889836755 0.369226837775464 0.927386879484551 0.625 30.4 30 4 abnormal epidermal lamellar body morphology 0.177703889836755 0.369226837775464 0.927386879484551 0.625 30.4 30 4 enlarged inguinal lymph nodes 0.177703889836755 0.369226837775464 0.927386879484551 0.625 30.4 30 4 urinary bladder inflammation 0.177703889836755 0.369226837775464 0.927386879484551 0.625 30.4 30 4 abnormal meiotic spindle morphology 0.177703889836755 0.369226837775464 0.927386879484551 0.625 30.4 30 4 abnormal base-excision repair 0.177703889836755 0.369226837775464 0.927386879484551 0.625 30.4 30 4 abnormal sphingomyelin level 0.177703889836755 0.369226837775464 0.927386879484551 0.625 30.4 30 4 decreased hippocampus pyramidal cell number 0.177703889836755 0.369226837775464 0.927386879484551 0.625 30.4 30 4 decreased susceptibility to weight loss 0.177703889836755 0.369226837775464 0.927386879484551 0.625 30.4 30 4 abnormal hepatic vein morphology 0.177703889836755 0.369226837775464 0.927386879484551 0.625 30.4 30 4 anomalous pulmonary venous connection 0.177703889836755 0.369226837775464 0.927386879484551 0.625 30.4 30 4 myocardial trabeculae hypoplasia 0.177703889836755 0.369226837775464 0.927386879484551 0.625 30.4 30 4 sinoatrial block 0.177703889836755 0.369226837775464 0.927386879484551 0.625 30.4 30 4 abnormal stomach position or orientation 0.177703889836755 0.369226837775464 0.927386879484551 0.625 30.4 30 4 abnormal bronchiole epithelium morphology 0.177703889836755 0.369226837775464 0.927386879484551 0.625 30.4 30 4 abnormal maxillary prominence morphology 0.177703889836755 0.369226837775464 0.927386879484551 0.625 30.4 30 4 abnormal bronchus epithelium morphology 0.177703889836755 0.369226837775464 0.927386879484551 0.625 30.4 30 4 abnormal branching involved in ureteric bud morphogenesis 0.177703889836755 0.369226837775464 0.927386879484551 0.625 30.4 30 4 decreased surfactant secretion 0.177703889836755 0.369226837775464 0.927386879484551 0.625 30.4 30 4 increased aorta wall thickness 0.177703889836755 0.369226837775464 0.927386879484551 0.625 30.4 30 4 increased circulating ferritin level 0.177703889836755 0.369226837775464 0.927386879484551 0.625 30.4 30 4 increased cardiac stroke volume 0.177703889836755 0.369226837775464 0.927386879484551 0.625 30.4 30 4 small thymus medulla 0.177703889836755 0.369226837775464 0.927386879484551 0.625 30.4 30 4 increased testis apoptosis 0.177703889836755 0.369226837775464 0.927386879484551 0.625 30.4 30 4 increased brain apoptosis 0.177703889836755 0.369226837775464 0.927386879484551 0.625 30.4 30 4 decreased vascular endothelial cell proliferation 0.177703889836755 0.369226837775464 0.927386879484551 0.625 30.4 30 4 postnatal lethality, complete penetrance 8.69722898056431e-19 1.7307485671323e-16 0.92642585681151 0.624352331606218 30.4 30 4 abnormal enzyme/coenzyme activity 1.64550610543131e-08 5.84742348180056e-07 0.926205494924698 0.624203821656051 30.4 30 4 postnatal growth retardation 6.27225846235588e-29 2.83677144092914e-26 0.926174609053852 0.624183006535948 30.4 30 4 abnormal cardiovascular system physiology 2.01900970837289e-07 5.48883786839079e-06 0.925992312748484 0.62406015037594 30.4 30 4 abnormal retina morphology 7.43932871429439e-11 4.02289786452333e-09 0.925620428285533 0.623809523809524 30.4 30 4 abnormal epidermal layer morphology 0.000175274890608505 0.00208112787775015 0.924698801573002 0.623188405797101 30.4 30 4 azoospermia 1.67987214835912e-08 5.88546756203284e-07 0.923887306354421 0.622641509433962 30.4 30 4 abnormal mesoderm development 0.000990649032510999 0.0084151870734199 0.923887306354421 0.622641509433962 30.4 30 4 abnormal ovarian follicle morphology 0.00238609330001618 0.016922629696508 0.923265160020175 0.622222222222222 30.4 30 4 small placenta 0.00238609330001618 0.016922629696508 0.923265160020175 0.622222222222222 30.4 30 4 decreased osteoclast cell number 0.00238609330001618 0.016922629696508 0.923265160020175 0.622222222222222 30.4 30 4 decreased T cell proliferation 5.93214072876168e-08 1.76720958835864e-06 0.922373977433283 0.621621621621622 30.4 30 4 impaired skeletal muscle contractility 0.00582294681834997 0.0338103458074484 0.922373977433283 0.621621621621622 30.4 30 4 decreased circulating chloride level 0.00582294681834997 0.0338103458074484 0.922373977433283 0.621621621621622 30.4 30 4 increased trabecular bone volume 0.00582294681834997 0.0338103458074484 0.922373977433283 0.621621621621622 30.4 30 4 abnormal skin morphology 0.000271709578157061 0.00295788873376669 0.921766352942221 0.621212121212121 30.4 30 4 increased blood urea nitrogen level 9.09034152784779e-08 2.59910627017487e-06 0.920991107901899 0.620689655172414 30.4 30 4 absent long term depression 0.0144858469291113 0.0668212323599583 0.920991107901899 0.620689655172414 30.4 30 4 short sternum 0.0144858469291113 0.0668212323599583 0.920991107901899 0.620689655172414 30.4 30 4 neonatal lethality, complete penetrance 2.95452676445826e-21 8.64633567834108e-19 0.920878901382905 0.620614035087719 30.4 30 4 hunched posture 7.56465648518195e-05 0.00100357776036747 0.920343434830238 0.620253164556962 30.4 30 4 abnormal somite development 7.56465648518195e-05 0.00100357776036747 0.920343434830238 0.620253164556962 30.4 30 4 kyphosis 6.03906257749468e-08 1.78835335256167e-06 0.919967784448675 0.62 30.4 30 4 increased circulating chloride level 0.00154519849339476 0.0121443325507724 0.919967784448675 0.62 30.4 30 4 testicular atrophy 0.00154519849339476 0.0121443325507724 0.919967784448675 0.62 30.4 30 4 abnormal bone mineralization 1.12118471662606e-06 2.51256484919578e-05 0.919722525108646 0.619834710743802 30.4 30 4 atelectasis 0.000178029763070915 0.00210379589377151 0.919549807263555 0.619718309859155 30.4 30 4 abnormal skeletal muscle fiber morphology 0.000178029763070915 0.00210379589377151 0.919549807263555 0.619718309859155 30.4 30 4 small ears 0.0371676989104418 0.134773543789685 0.91855462348946 0.619047619047619 30.4 30 4 vascular ring 0.0371676989104418 0.134773543789685 0.91855462348946 0.619047619047619 30.4 30 4 increased circulating insulin level 2.66553119580046e-08 8.72435374941268e-07 0.918113010689706 0.61875 30.4 30 4 increased sensitivity to xenobiotic induced morbidity/mortality 3.98754625051924e-06 7.9036026280212e-05 0.917269931708356 0.618181818181818 30.4 30 4 abnormal platelet physiology 0.00100330916524621 0.00847692311492647 0.917269931708356 0.618181818181818 30.4 30 4 decreased pancreatic beta cell number 0.00918733832214044 0.047463144499116 0.916476445608262 0.617647058823529 30.4 30 4 abnormal nervous system development 0.00918733832214044 0.047463144499116 0.916476445608262 0.617647058823529 30.4 30 4 decreased regulatory T cell number 0.00918733832214044 0.047463144499116 0.916476445608262 0.617647058823529 30.4 30 4 increased susceptibility to viral infection induced morbidity/mortality 0.00918733832214044 0.047463144499116 0.916476445608262 0.617647058823529 30.4 30 4 hepatic necrosis 0.00241119031937742 0.0170635445788089 0.915547898044323 0.617021276595745 30.4 30 4 decreased B cell number 4.35738676759262e-10 2.04509426120503e-08 0.914781620928451 0.616504854368932 30.4 30 4 decreased circulating glucose level 3.92675662268498e-13 3.20255970456685e-11 0.914755803706625 0.616487455197133 30.4 30 4 increased or absent threshold for auditory brainstem response 1.73889472499064e-13 1.49155194083249e-11 0.913909284696194 0.615916955017301 30.4 30 4 acanthosis 0.0058653674186066 0.0338474787837058 0.913119389030943 0.615384615384615 30.4 30 4 abnormal lens fiber morphology 0.0058653674186066 0.0338474787837058 0.913119389030943 0.615384615384615 30.4 30 4 increased susceptibility to otitis media 0.0230930940281532 0.0952637999917598 0.913119389030943 0.615384615384615 30.4 30 4 decreased circulating glycerol level 0.0230930940281532 0.0952637999917598 0.913119389030943 0.615384615384615 30.4 30 4 abnormal nerve conduction 0.0230930940281532 0.0952637999917598 0.913119389030943 0.615384615384615 30.4 30 4 absent common myeloid progenitor cells 0.101086994687829 0.268792235644317 0.913119389030943 0.615384615384615 30.4 30 4 absent trabeculae carneae 0.101086994687829 0.268792235644317 0.913119389030943 0.615384615384615 30.4 30 4 tight skin 0.101086994687829 0.268792235644317 0.913119389030943 0.615384615384615 30.4 30 4 excessive scratching 0.101086994687829 0.268792235644317 0.913119389030943 0.615384615384615 30.4 30 4 abnormal digestion 0.101086994687829 0.268792235644317 0.913119389030943 0.615384615384615 30.4 30 4 increased pituitary adenoma incidence 0.101086994687829 0.268792235644317 0.913119389030943 0.615384615384615 30.4 30 4 abnormal soleus morphology 0.101086994687829 0.268792235644317 0.913119389030943 0.615384615384615 30.4 30 4 abnormal dopaminergic neuron morphology 0.101086994687829 0.268792235644317 0.913119389030943 0.615384615384615 30.4 30 4 small otic vesicle 0.101086994687829 0.268792235644317 0.913119389030943 0.615384615384615 30.4 30 4 increased circulating thyroid-stimulating hormone level 0.101086994687829 0.268792235644317 0.913119389030943 0.615384615384615 30.4 30 4 decreased luteinizing hormone level 0.101086994687829 0.268792235644317 0.913119389030943 0.615384615384615 30.4 30 4 abnormal exocrine pancreas morphology 0.101086994687829 0.268792235644317 0.913119389030943 0.615384615384615 30.4 30 4 increased circulating ammonia level 0.101086994687829 0.268792235644317 0.913119389030943 0.615384615384615 30.4 30 4 small pituitary gland 0.101086994687829 0.268792235644317 0.913119389030943 0.615384615384615 30.4 30 4 orthokeratosis 0.101086994687829 0.268792235644317 0.913119389030943 0.615384615384615 30.4 30 4 empty decidua capsularis 0.101086994687829 0.268792235644317 0.913119389030943 0.615384615384615 30.4 30 4 increased prostaglandin level 0.101086994687829 0.268792235644317 0.913119389030943 0.615384615384615 30.4 30 4 decreased T cell number 4.18769001764552e-08 1.30210986486165e-06 0.912410445405919 0.614906832298137 30.4 30 4 abnormal gait 3.40619536967544e-14 3.38916439282706e-12 0.912380619298717 0.614886731391586 30.4 30 4 incomplete embryo turning 0.00101212236515356 0.00848128426127199 0.911116934230436 0.614035087719298 30.4 30 4 absent vitelline blood vessels 0.00101212236515356 0.00848128426127199 0.911116934230436 0.614035087719298 30.4 30 4 increased circulating triglyceride level 2.21846555380367e-07 5.91524428360687e-06 0.910757873369656 0.613793103448276 30.4 30 4 abnormal blood vessel morphology 2.21846555380367e-07 5.91524428360687e-06 0.910757873369656 0.613793103448276 30.4 30 4 increased circulating cholesterol level 1.2233822656937e-08 4.47524027340157e-07 0.910525299857559 0.613636363636364 30.4 30 4 abnormal gametogenesis 0.00376406013701803 0.024457246681609 0.910525299857559 0.613636363636364 30.4 30 4 renal interstitial fibrosis 0.00376406013701803 0.024457246681609 0.910525299857559 0.613636363636364 30.4 30 4 cochlear hair cell degeneration 0.00376406013701803 0.024457246681609 0.910525299857559 0.613636363636364 30.4 30 4 prenatal lethality 0.00065826185073634 0.00604216366681419 0.909437456010657 0.612903225806452 30.4 30 4 increased lung adenoma incidence 0.0145193471720834 0.0668212323599583 0.909437456010657 0.612903225806452 30.4 30 4 abnormal nose morphology 0.0145193471720834 0.0668212323599583 0.909437456010657 0.612903225806452 30.4 30 4 abnormal CD8-positive, alpha beta T cell morphology 0.0145193471720834 0.0668212323599583 0.909437456010657 0.612903225806452 30.4 30 4 decreased susceptibility to bacterial infection induced morbidity/mortality 0.0145193471720834 0.0668212323599583 0.909437456010657 0.612903225806452 30.4 30 4 abnormal retinal pigment epithelium morphology 0.000119197535305239 0.00147994151741772 0.90883914189486 0.6125 30.4 30 4 male infertility 1.07615960163016e-21 3.34618376131877e-19 0.908581022286256 0.612326043737575 30.4 30 4 abnormal reflex 0.00920800017587661 0.0474712962435089 0.906778282162672 0.611111111111111 30.4 30 4 head tilt 0.00920800017587661 0.0474712962435089 0.906778282162672 0.611111111111111 30.4 30 4 abnormal megakaryocyte differentiation 0.0603223050091845 0.192390304732296 0.906778282162672 0.611111111111111 30.4 30 4 underdeveloped hair follicles 0.0603223050091845 0.192390304732296 0.906778282162672 0.611111111111111 30.4 30 4 abnormal radius morphology 0.0603223050091845 0.192390304732296 0.906778282162672 0.611111111111111 30.4 30 4 abnormal mammary gland morphology 0.0603223050091845 0.192390304732296 0.906778282162672 0.611111111111111 30.4 30 4 absent spleen 0.0603223050091845 0.192390304732296 0.906778282162672 0.611111111111111 30.4 30 4 abnormal phrenic nerve morphology 0.0603223050091845 0.192390304732296 0.906778282162672 0.611111111111111 30.4 30 4 abnormal white adipose tissue morphology 0.0603223050091845 0.192390304732296 0.906778282162672 0.611111111111111 30.4 30 4 abnormal metacarpal bone morphology 0.0603223050091845 0.192390304732296 0.906778282162672 0.611111111111111 30.4 30 4 darkened coat color 0.0603223050091845 0.192390304732296 0.906778282162672 0.611111111111111 30.4 30 4 decreased pulmonary respiratory rate 0.0603223050091845 0.192390304732296 0.906778282162672 0.611111111111111 30.4 30 4 primary atelectasis 0.0603223050091845 0.192390304732296 0.906778282162672 0.611111111111111 30.4 30 4 impaired leukocyte tethering or rolling 0.0603223050091845 0.192390304732296 0.906778282162672 0.611111111111111 30.4 30 4 impaired righting response 3.37371885593281e-05 0.000501022427112409 0.905910551749119 0.610526315789474 30.4 30 4 syndactyly 0.00101740328284563 0.00848128426127199 0.905381089123901 0.610169491525424 30.4 30 4 increased B cell proliferation 0.00101740328284563 0.00848128426127199 0.905381089123901 0.610169491525424 30.4 30 4 increased circulating glucose level 5.20220293639796e-07 1.28123562418712e-05 0.905024358986342 0.609929078014184 30.4 30 4 abnormal excitatory postsynaptic potential 0.000119957236362088 0.00148454540025221 0.904767687302001 0.609756097560976 30.4 30 4 short humerus 0.00587823551138126 0.0338474787837058 0.904767687302001 0.609756097560976 30.4 30 4 hemopericardium 0.00587823551138126 0.0338474787837058 0.904767687302001 0.609756097560976 30.4 30 4 abnormal cholesterol homeostasis 0.00587823551138126 0.0338474787837058 0.904767687302001 0.609756097560976 30.4 30 4 abnormal humoral immune response 1.46096021257898e-05 0.000239877130613215 0.904423013897315 0.60952380952381 30.4 30 4 abnormal lymphocyte physiology 0.00377213376425449 0.0244672300875699 0.903194178280606 0.608695652173913 30.4 30 4 abnormal B cell morphology 0.0369352963997574 0.134635472123069 0.903194178280606 0.608695652173913 30.4 30 4 abnormal ulna morphology 0.0369352963997574 0.134635472123069 0.903194178280606 0.608695652173913 30.4 30 4 abnormal hematopoietic stem cell physiology 0.0369352963997574 0.134635472123069 0.903194178280606 0.608695652173913 30.4 30 4 abnormal coat appearance 0.000431002551885606 0.00429683276788968 0.903194178280606 0.608695652173913 30.4 30 4 abnormal angiogenesis 0.000281343414716205 0.00303427230096581 0.902322369228212 0.608108108108108 30.4 30 4 reduced male fertility 3.13254512909949e-10 1.57418303204747e-08 0.902057370000832 0.607929515418502 30.4 30 4 distended abdomen 0.00243082826660966 0.0171051918336394 0.901929200439877 0.607843137254902 30.4 30 4 abnormal thrombosis 0.00243082826660966 0.0171051918336394 0.901929200439877 0.607843137254902 30.4 30 4 abnormal placenta labyrinth morphology 0.000183948004601706 0.00215835217663558 0.90156091575207 0.607594936708861 30.4 30 4 increased T cell proliferation 1.46840259697586e-05 0.00024030601710378 0.901385378190592 0.607476635514019 30.4 30 4 abnormal coat/hair pigmentation 9.67183056414061e-06 0.000171413619053507 0.900890111499278 0.607142857142857 30.4 30 4 abnormal eye development 0.0015719165975477 0.0122960457119494 0.900890111499278 0.607142857142857 30.4 30 4 abnormal somite shape 0.0229867976415823 0.0952637999917598 0.900890111499278 0.607142857142857 30.4 30 4 absent corpus callosum 0.0229867976415823 0.0952637999917598 0.900890111499278 0.607142857142857 30.4 30 4 enhanced coordination 0.0229867976415823 0.0952637999917598 0.900890111499278 0.607142857142857 30.4 30 4 abnormal renal tubule epithelium morphology 0.0229867976415823 0.0952637999917598 0.900890111499278 0.607142857142857 30.4 30 4 increased neutrophil cell number 5.26344501921183e-07 1.28360975345975e-05 0.900524638837413 0.606896551724138 30.4 30 4 decreased startle reflex 6.37471285488003e-06 0.000119798728622775 0.900437175294402 0.606837606837607 30.4 30 4 increased B cell number 6.37471285488003e-06 0.000119798728622775 0.900437175294402 0.606837606837607 30.4 30 4 increased osteoclast cell number 0.00101945889210867 0.00848128426127199 0.900021365007958 0.60655737704918 30.4 30 4 abnormal locomotor coordination 0.0144684443101993 0.0668212323599583 0.899284246772898 0.606060606060606 30.4 30 4 abnormal QRS complex 0.0144684443101993 0.0668212323599583 0.899284246772898 0.606060606060606 30.4 30 4 cardiovascular system phenotype 0.0144684443101993 0.0668212323599583 0.899284246772898 0.606060606060606 30.4 30 4 decreased liver weight 0.000431842489235143 0.00429683276788968 0.898650948007565 0.605633802816901 30.4 30 4 increased grooming behavior 0.00918287391050843 0.047463144499116 0.898100978027144 0.605263157894737 30.4 30 4 abnormal retinal outer nuclear layer morphology 0.00918287391050843 0.047463144499116 0.898100978027144 0.605263157894737 30.4 30 4 impaired macrophage phagocytosis 0.0058655808633434 0.0338474787837058 0.897192888059473 0.604651162790698 30.4 30 4 oligodactyly 0.00376567858454522 0.024457246681609 0.896473983501733 0.604166666666667 30.4 30 4 small heart 0.00376567858454522 0.024457246681609 0.896473983501733 0.604166666666667 30.4 30 4 abnormal phalanx morphology 0.00376567858454522 0.024457246681609 0.896473983501733 0.604166666666667 30.4 30 4 impaired coordination 2.54629416493909e-14 2.58526805521877e-12 0.896295296241717 0.604046242774566 30.4 30 4 enlarged kidney 0.00242751287537039 0.0171051918336394 0.895890721313378 0.60377358490566 30.4 30 4 abnormal pancreatic islet morphology 0.00242751287537039 0.0171051918336394 0.895890721313378 0.60377358490566 30.4 30 4 reduced female fertility 4.8191141563348e-10 2.24066289044539e-08 0.895408021571291 0.603448275862069 30.4 30 4 thrombocytosis 0.00157021121586479 0.0122960457119494 0.895408021571291 0.603448275862069 30.4 30 4 skin lesions 0.00101858507303038 0.00848128426127199 0.895001940835884 0.603174603174603 30.4 30 4 decreased susceptibility to hepatic steatosis 0.00101858507303038 0.00848128426127199 0.895001940835884 0.603174603174603 30.4 30 4 abnormal heart ventricle morphology 0.000281775638803257 0.00303427230096581 0.894096068426131 0.602564102564103 30.4 30 4 short femur 0.000120642776789435 0.00148932460180506 0.893663720230567 0.602272727272727 30.4 30 4 no abnormal phenotype detected 1.07375614544464e-65 2.67096841179355e-62 0.892001858492115 0.601152737752161 30.4 30 4 decreased heart rate 5.18248080680832e-05 0.00073039212503885 0.890291404305169 0.6 30.4 30 4 abnormal hindlimb morphology 0.00374653566230301 0.024457246681609 0.890291404305169 0.6 30.4 30 4 increased body length 0.00374653566230301 0.024457246681609 0.890291404305169 0.6 30.4 30 4 kidney inflammation 0.00374653566230301 0.024457246681609 0.890291404305169 0.6 30.4 30 4 abnormal pericardium morphology 0.0592983792713649 0.192390304732296 0.890291404305169 0.6 30.4 30 4 waved hair 0.0592983792713649 0.192390304732296 0.890291404305169 0.6 30.4 30 4 brain inflammation 0.0592983792713649 0.192390304732296 0.890291404305169 0.6 30.4 30 4 anencephaly 0.0592983792713649 0.192390304732296 0.890291404305169 0.6 30.4 30 4 abnormal hyoid bone morphology 0.0592983792713649 0.192390304732296 0.890291404305169 0.6 30.4 30 4 kidney atrophy 0.0592983792713649 0.192390304732296 0.890291404305169 0.6 30.4 30 4 abnormal response to tactile stimuli 0.0592983792713649 0.192390304732296 0.890291404305169 0.6 30.4 30 4 increased urine calcium level 0.0592983792713649 0.192390304732296 0.890291404305169 0.6 30.4 30 4 abnormal lateral semicircular canal morphology 0.170594578743402 0.369226837775464 0.890291404305169 0.6 30.4 30 4 kidney hemorrhage 0.170594578743402 0.369226837775464 0.890291404305169 0.6 30.4 30 4 abnormal mammary gland physiology 0.170594578743402 0.369226837775464 0.890291404305169 0.6 30.4 30 4 abnormal airway responsiveness 0.170594578743402 0.369226837775464 0.890291404305169 0.6 30.4 30 4 ketoaciduria 0.170594578743402 0.369226837775464 0.890291404305169 0.6 30.4 30 4 decreased circulating parathyroid hormone level 0.170594578743402 0.369226837775464 0.890291404305169 0.6 30.4 30 4 delayed dark adaptation 0.170594578743402 0.369226837775464 0.890291404305169 0.6 30.4 30 4 impaired basement membrane formation 0.170594578743402 0.369226837775464 0.890291404305169 0.6 30.4 30 4 abnormal tibialis anterior morphology 0.170594578743402 0.369226837775464 0.890291404305169 0.6 30.4 30 4 aneurysm 0.170594578743402 0.369226837775464 0.890291404305169 0.6 30.4 30 4 intestinal hypoperistalsis 0.170594578743402 0.369226837775464 0.890291404305169 0.6 30.4 30 4 peritoneal inflammation 0.170594578743402 0.369226837775464 0.890291404305169 0.6 30.4 30 4 abnormal submandibular gland morphology 0.170594578743402 0.369226837775464 0.890291404305169 0.6 30.4 30 4 increased defecation amount 0.170594578743402 0.369226837775464 0.890291404305169 0.6 30.4 30 4 absent pharyngeal arches 0.170594578743402 0.369226837775464 0.890291404305169 0.6 30.4 30 4 decreased cochlear inner hair cell number 0.170594578743402 0.369226837775464 0.890291404305169 0.6 30.4 30 4 ascites 0.170594578743402 0.369226837775464 0.890291404305169 0.6 30.4 30 4 vascular smooth muscle hyperplasia 0.170594578743402 0.369226837775464 0.890291404305169 0.6 30.4 30 4 absent axillary lymph nodes 0.170594578743402 0.369226837775464 0.890291404305169 0.6 30.4 30 4 impaired behavioral response to morphine 0.170594578743402 0.369226837775464 0.890291404305169 0.6 30.4 30 4 protruding tongue 0.170594578743402 0.369226837775464 0.890291404305169 0.6 30.4 30 4 abnormal hippocampus neuron morphology 0.170594578743402 0.369226837775464 0.890291404305169 0.6 30.4 30 4 abnormal cerebellar granule cell migration 0.170594578743402 0.369226837775464 0.890291404305169 0.6 30.4 30 4 increased T-helper 17 cell number 0.170594578743402 0.369226837775464 0.890291404305169 0.6 30.4 30 4 increased kidney iron level 0.170594578743402 0.369226837775464 0.890291404305169 0.6 30.4 30 4 abnormal heart and great artery attachment 0.170594578743402 0.369226837775464 0.890291404305169 0.6 30.4 30 4 common ventricle 0.170594578743402 0.369226837775464 0.890291404305169 0.6 30.4 30 4 aorta stenosis 0.170594578743402 0.369226837775464 0.890291404305169 0.6 30.4 30 4 abnormal left subclavian artery morphology 0.170594578743402 0.369226837775464 0.890291404305169 0.6 30.4 30 4 abnormal pulmonary interalveolar septum morphology 0.170594578743402 0.369226837775464 0.890291404305169 0.6 30.4 30 4 decreased circulating lactate level 0.170594578743402 0.369226837775464 0.890291404305169 0.6 30.4 30 4 increased circulating HDL cholesterol level 3.40536058392027e-05 0.000504216336458434 0.890291404305169 0.6 30.4 30 4 cardiac fibrosis 0.000183830188696276 0.00215835217663558 0.890291404305169 0.6 30.4 30 4 dehydration 0.000660318995686545 0.00604988398442093 0.890291404305169 0.6 30.4 30 4 intracranial hemorrhage 0.00156408772329507 0.0122734012987271 0.890291404305169 0.6 30.4 30 4 abnormal autopod morphology 0.00583101039252075 0.0338103458074484 0.890291404305169 0.6 30.4 30 4 increased circulating corticosterone level 0.00583101039252075 0.0338103458074484 0.890291404305169 0.6 30.4 30 4 decreased circulating thyroxine level 0.0143485881594608 0.0665942988933088 0.890291404305169 0.6 30.4 30 4 abnormal hippocampus pyramidal cell morphology 0.0143485881594608 0.0665942988933088 0.890291404305169 0.6 30.4 30 4 disorganized myocardium 0.0227537394191435 0.0949897891079752 0.890291404305169 0.6 30.4 30 4 decreased chondrocyte number 0.0986341080941584 0.267508632300152 0.890291404305169 0.6 30.4 30 4 decreased hepatocyte number 0.0986341080941584 0.267508632300152 0.890291404305169 0.6 30.4 30 4 abnormal enteric neuron morphology 0.0986341080941584 0.267508632300152 0.890291404305169 0.6 30.4 30 4 vagina atresia 0.0986341080941584 0.267508632300152 0.890291404305169 0.6 30.4 30 4 abnormal seizure response to electrical stimulation 0.0986341080941584 0.267508632300152 0.890291404305169 0.6 30.4 30 4 abnormal respiratory system morphology 0.0986341080941584 0.267508632300152 0.890291404305169 0.6 30.4 30 4 abnormal lymph node B cell domain morphology 0.0986341080941584 0.267508632300152 0.890291404305169 0.6 30.4 30 4 altered righting response 0.0986341080941584 0.267508632300152 0.890291404305169 0.6 30.4 30 4 abnormal olfactory nerve morphology 0.0986341080941584 0.267508632300152 0.890291404305169 0.6 30.4 30 4 abnormal zygomatic bone morphology 0.0986341080941584 0.267508632300152 0.890291404305169 0.6 30.4 30 4 abnormal neurotransmitter secretion 0.0986341080941584 0.267508632300152 0.890291404305169 0.6 30.4 30 4 abnormal energy homeostasis 0.0986341080941584 0.267508632300152 0.890291404305169 0.6 30.4 30 4 abnormal dendritic cell morphology 0.0986341080941584 0.267508632300152 0.890291404305169 0.6 30.4 30 4 abnormal cerebral aqueduct morphology 0.0986341080941584 0.267508632300152 0.890291404305169 0.6 30.4 30 4 abnormal aorta wall morphology 0.0986341080941584 0.267508632300152 0.890291404305169 0.6 30.4 30 4 abnormal coronary vessel morphology 0.0986341080941584 0.267508632300152 0.890291404305169 0.6 30.4 30 4 abnormal microglial cell activation 0.0986341080941584 0.267508632300152 0.890291404305169 0.6 30.4 30 4 herniated liver 0.0986341080941584 0.267508632300152 0.890291404305169 0.6 30.4 30 4 hyperactivity 1.69334480806497e-14 1.75508133752567e-12 0.887891697015937 0.598382749326146 30.4 30 4 increased anxiety-related response 2.76963951380028e-06 5.62406391067607e-05 0.886021421550708 0.597122302158273 30.4 30 4 increased susceptibility to injury 0.0037163773411134 0.0244240122484005 0.884584408123726 0.596153846153846 30.4 30 4 deafness 7.82685182025178e-05 0.00103002830493687 0.88429617599335 0.595959595959596 30.4 30 4 neuron degeneration 0.00577773463038915 0.0336978074867362 0.883977280870381 0.595744680851064 30.4 30 4 decreased bone trabecula number 0.00577773463038915 0.0336978074867362 0.883977280870381 0.595744680851064 30.4 30 4 decreased rib number 0.000182012191500072 0.0021457598405518 0.883622554834718 0.595505617977528 30.4 30 4 hydronephrosis 0.000278076707278683 0.00300746004067706 0.883225599509096 0.595238095238095 30.4 30 4 abnormal nervous system electrophysiology 0.000278076707278683 0.00300746004067706 0.883225599509096 0.595238095238095 30.4 30 4 abnormal spatial learning 5.23504233599114e-07 1.2829721981062e-05 0.883008857030689 0.595092024539877 30.4 30 4 abnormal myocardium layer morphology 0.000425459976536788 0.00425032807885647 0.882778396673902 0.594936708860759 30.4 30 4 small seminiferous tubules 0.000652030037555296 0.00604068796431583 0.882270761023141 0.594594594594595 30.4 30 4 abnormal hair follicle development 0.014172745100249 0.0660819183446472 0.882270761023141 0.594594594594595 30.4 30 4 abnormal kidney morphology 2.27985679660592e-07 6.03313168250768e-06 0.881812438549882 0.594285714285714 30.4 30 4 hyperkeratosis 0.00100113607651519 0.00847692311492647 0.881689554988211 0.594202898550725 30.4 30 4 neonatal lethality 0.0224216606013301 0.0938954221309907 0.881017535510324 0.59375 30.4 30 4 abnormal heart atrium morphology 0.0224216606013301 0.0938954221309907 0.881017535510324 0.59375 30.4 30 4 abnormal serotonin level 0.0224216606013301 0.0938954221309907 0.881017535510324 0.59375 30.4 30 4 decreased heart weight 0.00042184376535731 0.00422268155463303 0.879300152400167 0.592592592592593 30.4 30 4 abnormal trigeminal ganglion morphology 0.0358109536905188 0.132067824025449 0.879300152400167 0.592592592592593 30.4 30 4 abnormal brain commissure morphology 0.0358109536905188 0.132067824025449 0.879300152400167 0.592592592592593 30.4 30 4 organ of Corti degeneration 0.00570859915874664 0.0334514497229264 0.87817859608333 0.591836734693878 30.4 30 4 decreased circulating creatinine level 0.00570859915874664 0.0334514497229264 0.87817859608333 0.591836734693878 30.4 30 4 increased fluid intake 0.00570859915874664 0.0334514497229264 0.87817859608333 0.591836734693878 30.4 30 4 abnormal CD4-positive, alpha-beta T cell physiology 0.000991216005029962 0.0084151870734199 0.877752088751575 0.591549295774648 30.4 30 4 abnormal nervous system physiology 3.30808675958782e-05 0.000492746455956569 0.877388630329732 0.591304347826087 30.4 30 4 abnormal circadian rhythm 0.00890111080136904 0.0466628305972718 0.876802140603576 0.590909090909091 30.4 30 4 abnormal basisphenoid bone morphology 0.0579521609485712 0.190430647766936 0.876802140603576 0.590909090909091 30.4 30 4 abnormal vascular branching morphogenesis 0.0579521609485712 0.190430647766936 0.876802140603576 0.590909090909091 30.4 30 4 decreased cardiac output 0.0579521609485712 0.190430647766936 0.876802140603576 0.590909090909091 30.4 30 4 abnormal female reproductive system physiology 0.0579521609485712 0.190430647766936 0.876802140603576 0.590909090909091 30.4 30 4 abnormal retinal outer plexiform layer morphology 0.0579521609485712 0.190430647766936 0.876802140603576 0.590909090909091 30.4 30 4 prolonged PR interval 0.0579521609485712 0.190430647766936 0.876802140603576 0.590909090909091 30.4 30 4 abnormal circulating lipid level 0.0579521609485712 0.190430647766936 0.876802140603576 0.590909090909091 30.4 30 4 abnormal basement membrane morphology 0.0579521609485712 0.190430647766936 0.876802140603576 0.590909090909091 30.4 30 4 cleft upper lip 0.0579521609485712 0.190430647766936 0.876802140603576 0.590909090909091 30.4 30 4 abnormal cerebral cortex pyramidal cell morphology 0.0579521609485712 0.190430647766936 0.876802140603576 0.590909090909091 30.4 30 4 short tail 0.00041757219996859 0.0041883501912172 0.875989534356492 0.590361445783133 30.4 30 4 impaired macrophage chemotaxis 0.0139517894926173 0.0652351059452735 0.87507274782132 0.58974358974359 30.4 30 4 decreased B-1 B cell number 0.0139517894926173 0.0652351059452735 0.87507274782132 0.58974358974359 30.4 30 4 abnormal circulating hormone level 0.0139517894926173 0.0652351059452735 0.87507274782132 0.58974358974359 30.4 30 4 abnormal dendritic cell physiology 7.5631748290694e-05 0.00100357776036747 0.873650443477035 0.588785046728972 30.4 30 4 circling 0.00041271459096783 0.0041648176269066 0.872834710103107 0.588235294117647 30.4 30 4 decreased circulating alanine transaminase level 0.00150459681276322 0.0119004278910923 0.872834710103107 0.588235294117647 30.4 30 4 abnormal response to novel object 0.00562611765615065 0.0331145531413254 0.872834710103107 0.588235294117647 30.4 30 4 cochlear inner hair cell degeneration 0.00562611765615065 0.0331145531413254 0.872834710103107 0.588235294117647 30.4 30 4 short maxilla 0.0220128814359978 0.0928872647532561 0.872834710103107 0.588235294117647 30.4 30 4 abnormal oocyte morphology 0.0220128814359978 0.0928872647532561 0.872834710103107 0.588235294117647 30.4 30 4 overexpanded pulmonary alveoli 0.0220128814359978 0.0928872647532561 0.872834710103107 0.588235294117647 30.4 30 4 abnormal spleen red pulp morphology 0.0220128814359978 0.0928872647532561 0.872834710103107 0.588235294117647 30.4 30 4 increased susceptibility to weight gain 0.0220128814359978 0.0928872647532561 0.872834710103107 0.588235294117647 30.4 30 4 hydroureter 0.0956155065096428 0.267508632300152 0.872834710103107 0.588235294117647 30.4 30 4 abnormal vagus nerve morphology 0.0956155065096428 0.267508632300152 0.872834710103107 0.588235294117647 30.4 30 4 abnormal touch/ nociception 0.0956155065096428 0.267508632300152 0.872834710103107 0.588235294117647 30.4 30 4 abnormal cranial suture morphology 0.0956155065096428 0.267508632300152 0.872834710103107 0.588235294117647 30.4 30 4 absence seizures 0.0956155065096428 0.267508632300152 0.872834710103107 0.588235294117647 30.4 30 4 increased regulatory T cell number 0.0956155065096428 0.267508632300152 0.872834710103107 0.588235294117647 30.4 30 4 decreased growth hormone level 0.0956155065096428 0.267508632300152 0.872834710103107 0.588235294117647 30.4 30 4 abnormal circulating chemokine level 0.0956155065096428 0.267508632300152 0.872834710103107 0.588235294117647 30.4 30 4 abnormal survival 0.0956155065096428 0.267508632300152 0.872834710103107 0.588235294117647 30.4 30 4 abnormal posture 0.000631101024886731 0.00590174360678851 0.871743666715478 0.5875 30.4 30 4 abnormal hair follicle morphology 0.00231601056301072 0.0165548168835895 0.871449258182308 0.587301587301587 30.4 30 4 abnormal inner ear morphology 0.00875678244321494 0.046590318736362 0.870937243342013 0.58695652173913 30.4 30 4 abnormal limb morphology 0.000966561355027976 0.00829076334700721 0.870507150876165 0.586666666666667 30.4 30 4 glomerulosclerosis 0.00357417716776018 0.0235205441926017 0.869824935240682 0.586206896551724 30.4 30 4 abnormal parietal bone morphology 0.0350298111509163 0.130249110968467 0.869824935240682 0.586206896551724 30.4 30 4 abnormal microglial cell morphology 0.0350298111509163 0.130249110968467 0.869824935240682 0.586206896551724 30.4 30 4 increased susceptibility to induced arthritis 0.0350298111509163 0.130249110968467 0.869824935240682 0.586206896551724 30.4 30 4 decreased bone strength 0.0350298111509163 0.130249110968467 0.869824935240682 0.586206896551724 30.4 30 4 sparse hair 0.000622340736071425 0.00583515046172104 0.868576979809921 0.585365853658537 30.4 30 4 Leydig cell hyperplasia 0.0136948392764936 0.0642147270504766 0.868576979809921 0.585365853658537 30.4 30 4 scaly skin 0.0136948392764936 0.0642147270504766 0.868576979809921 0.585365853658537 30.4 30 4 arrested B cell differentiation 0.0136948392764936 0.0642147270504766 0.868576979809921 0.585365853658537 30.4 30 4 postnatal lethality 1.66114347719352e-06 3.5317046149734e-05 0.867050865638568 0.58433734939759 30.4 30 4 abnormal eye physiology 0.0035136118710295 0.0232759241789238 0.865561087518914 0.583333333333333 30.4 30 4 abnormal uterus morphology 0.0215454113364787 0.091301892162676 0.865561087518914 0.583333333333333 30.4 30 4 increased food intake 0.000612865889734472 0.00577463598755492 0.865561087518914 0.583333333333333 30.4 30 4 abnormal cardiovascular system morphology 0.00859461309457061 0.046590318736362 0.865561087518914 0.583333333333333 30.4 30 4 abnormal body weight 0.0563914413089842 0.187670068879443 0.865561087518914 0.583333333333333 30.4 30 4 small lymph nodes 0.0563914413089842 0.187670068879443 0.865561087518914 0.583333333333333 30.4 30 4 increased body temperature 0.0563914413089842 0.187670068879443 0.865561087518914 0.583333333333333 30.4 30 4 abnormal supraoccipital bone morphology 0.162811952798236 0.366014218333132 0.865561087518914 0.583333333333333 30.4 30 4 abnormal rectum morphology 0.162811952798236 0.366014218333132 0.865561087518914 0.583333333333333 30.4 30 4 abnormal superior cervical ganglion morphology 0.162811952798236 0.366014218333132 0.865561087518914 0.583333333333333 30.4 30 4 abnormal pilomotor reflex 0.162811952798236 0.366014218333132 0.865561087518914 0.583333333333333 30.4 30 4 abnormal tracheal ciliated epithelium morphology 0.162811952798236 0.366014218333132 0.865561087518914 0.583333333333333 30.4 30 4 abnormal corticospinal tract morphology 0.162811952798236 0.366014218333132 0.865561087518914 0.583333333333333 30.4 30 4 abnormal gastrocnemius morphology 0.162811952798236 0.366014218333132 0.865561087518914 0.583333333333333 30.4 30 4 abnormal aorta elastic fiber morphology 0.162811952798236 0.366014218333132 0.865561087518914 0.583333333333333 30.4 30 4 abnormal alisphenoid bone morphology 0.162811952798236 0.366014218333132 0.865561087518914 0.583333333333333 30.4 30 4 abnormal nucleotide metabolism 0.162811952798236 0.366014218333132 0.865561087518914 0.583333333333333 30.4 30 4 bowed ulna 0.162811952798236 0.366014218333132 0.865561087518914 0.583333333333333 30.4 30 4 small parietal bone 0.162811952798236 0.366014218333132 0.865561087518914 0.583333333333333 30.4 30 4 abnormal amacrine cell morphology 0.162811952798236 0.366014218333132 0.865561087518914 0.583333333333333 30.4 30 4 abnormal somatic nervous system physiology 0.162811952798236 0.366014218333132 0.865561087518914 0.583333333333333 30.4 30 4 decreased oligodendrocyte number 0.162811952798236 0.366014218333132 0.865561087518914 0.583333333333333 30.4 30 4 decreased mammary gland epithelial cell proliferation 0.162811952798236 0.366014218333132 0.865561087518914 0.583333333333333 30.4 30 4 increased skeletal muscle glycogen level 0.162811952798236 0.366014218333132 0.865561087518914 0.583333333333333 30.4 30 4 increased type II pneumocyte number 0.162811952798236 0.366014218333132 0.865561087518914 0.583333333333333 30.4 30 4 abnormal colon goblet cell morphology 0.162811952798236 0.366014218333132 0.865561087518914 0.583333333333333 30.4 30 4 abnormal visceral yolk sac morphology 0.000936767740377785 0.00804908377958459 0.863995877595734 0.582278481012658 30.4 30 4 decreased compact bone thickness 0.0022408159653491 0.0160866658407096 0.863715541490089 0.582089552238806 30.4 30 4 absent mature ovarian follicles 0.0341552056073805 0.127377921961558 0.861572326746938 0.580645161290323 30.4 30 4 abnormal capillary morphology 0.0341552056073805 0.127377921961558 0.861572326746938 0.580645161290323 30.4 30 4 increased body weight 5.5168326443879e-08 1.65338809673673e-06 0.861144959521369 0.580357142857143 30.4 30 4 abnormal suckling behavior 0.000592145083647321 0.00558998442342585 0.859940560976584 0.579545454545455 30.4 30 4 teratozoospermia 0.000592145083647321 0.00558998442342585 0.859940560976584 0.579545454545455 30.4 30 4 infertility 0.000162427635940612 0.00195187799228151 0.859782976120257 0.579439252336449 30.4 30 4 decreased grooming behavior 0.0922866662336307 0.259686744633661 0.859053109417269 0.578947368421053 30.4 30 4 abnormal metatarsal bone morphology 0.0922866662336307 0.259686744633661 0.859053109417269 0.578947368421053 30.4 30 4 osteoarthritis 0.0922866662336307 0.259686744633661 0.859053109417269 0.578947368421053 30.4 30 4 increased left ventricle weight 0.0922866662336307 0.259686744633661 0.859053109417269 0.578947368421053 30.4 30 4 abnormal cochlear inner hair cell morphology 0.0922866662336307 0.259686744633661 0.859053109417269 0.578947368421053 30.4 30 4 decreased liver glycogen level 0.0922866662336307 0.259686744633661 0.859053109417269 0.578947368421053 30.4 30 4 seizures 0.000105229946224454 0.00132872838189507 0.859053109417268 0.578947368421053 30.4 30 4 abnormal blood homeostasis 0.000105229946224454 0.00132872838189507 0.859053109417268 0.578947368421053 30.4 30 4 impaired natural killer cell mediated cytotoxicity 0.00531942927676499 0.0317316074962899 0.859053109417268 0.578947368421053 30.4 30 4 abnormal circulating amino acid level 0.00531942927676499 0.0317316074962899 0.859053109417268 0.578947368421053 30.4 30 4 decreased eosinophil cell number 0.00337876056485538 0.0224723714039512 0.85783286352321 0.578125 30.4 30 4 abnormal renal glomerulus morphology 0.00015951930572246 0.00192431243020913 0.857620160110484 0.577981651376147 30.4 30 4 abnormal rib morphology 2.88076353246366e-05 0.000432984851178451 0.857317648590163 0.577777777777778 30.4 30 4 abnormal cartilage development 0.0131023008345298 0.0620799491921768 0.857317648590163 0.577777777777778 30.4 30 4 increased urine protein level 0.00137927414885233 0.011139430017111 0.856049427216509 0.576923076923077 30.4 30 4 abnormal brain wave pattern 0.00823030899483784 0.0448966965453051 0.856049427216509 0.576923076923077 30.4 30 4 increased percent body fat/body weight 0.00823030899483784 0.0448966965453051 0.856049427216509 0.576923076923077 30.4 30 4 abnormal Schwann cell morphology 0.0546924495097095 0.184596293290912 0.856049427216509 0.576923076923077 30.4 30 4 pulmonary edema 0.0546924495097095 0.184596293290912 0.856049427216509 0.576923076923077 30.4 30 4 decreased Peyer's patch number 0.0546924495097095 0.184596293290912 0.856049427216509 0.576923076923077 30.4 30 4 decreased litter size 2.67329260276513e-09 1.08244504424301e-07 0.855440139367956 0.576512455516014 30.4 30 4 abnormal thoracic vertebrae morphology 0.00520316846184985 0.0312706896675667 0.855082139728129 0.576271186440678 30.4 30 4 abnormal aorta morphology 0.0332153112821501 0.125091728712109 0.854320034434253 0.575757575757576 30.4 30 4 belly spot 0.0332153112821501 0.125091728712109 0.854320034434253 0.575757575757576 30.4 30 4 dextrocardia 0.0332153112821501 0.125091728712109 0.854320034434253 0.575757575757576 30.4 30 4 abnormal T cell subpopulation ratio 0.0332153112821501 0.125091728712109 0.854320034434253 0.575757575757576 30.4 30 4 head bobbing 0.020489909050934 0.0881048379674992 0.853195929125787 0.575 30.4 30 4 increased susceptibility to weight loss 0.020489909050934 0.0881048379674992 0.853195929125787 0.575 30.4 30 4 abnormal response/metabolism to endogenous compounds 0.00132057700787264 0.0108057082469842 0.850481626063881 0.573170731707317 30.4 30 4 female infertility 1.8296050786148e-08 6.32103143479765e-07 0.847896575528733 0.571428571428571 30.4 30 4 increased thermal nociceptive threshold 0.000828816136856189 0.0072466788767303 0.847896575528733 0.571428571428571 30.4 30 4 increased sarcoma incidence 0.0124426316756693 0.0600991190159756 0.847896575528733 0.571428571428571 30.4 30 4 reddish skin 0.0529098284224343 0.179309534333522 0.847896575528733 0.571428571428571 30.4 30 4 irregularly shaped pupil 0.154923489439517 0.366014218333132 0.847896575528733 0.571428571428571 30.4 30 4 absent visceral yolk sac blood islands 0.154923489439517 0.366014218333132 0.847896575528733 0.571428571428571 30.4 30 4 decreased coping response 0.154923489439517 0.366014218333132 0.847896575528733 0.571428571428571 30.4 30 4 decreased vascular permeability 0.154923489439517 0.366014218333132 0.847896575528733 0.571428571428571 30.4 30 4 absent olfactory bulb 0.154923489439517 0.366014218333132 0.847896575528733 0.571428571428571 30.4 30 4 abnormal voluntary movement 0.154923489439517 0.366014218333132 0.847896575528733 0.571428571428571 30.4 30 4 vascular smooth muscle hypoplasia 0.154923489439517 0.366014218333132 0.847896575528733 0.571428571428571 30.4 30 4 abnormal decidualization 0.154923489439517 0.366014218333132 0.847896575528733 0.571428571428571 30.4 30 4 abnormal squamosal bone morphology 0.154923489439517 0.366014218333132 0.847896575528733 0.571428571428571 30.4 30 4 increased B-1 B cell number 0.154923489439517 0.366014218333132 0.847896575528733 0.571428571428571 30.4 30 4 increased pulmonary respiratory rate 0.154923489439517 0.366014218333132 0.847896575528733 0.571428571428571 30.4 30 4 decreased response to antigen 0.154923489439517 0.366014218333132 0.847896575528733 0.571428571428571 30.4 30 4 polyuria 0.00201396038394531 0.0148436339409303 0.847896575528732 0.571428571428571 30.4 30 4 abnormal pancreas morphology 0.0199232688582804 0.0867176400436963 0.847896575528732 0.571428571428571 30.4 30 4 abnormal salivary gland morphology 0.0888059530859291 0.251548380058473 0.847896575528732 0.571428571428571 30.4 30 4 abnormal anxiety-related response 0.0888059530859291 0.251548380058473 0.847896575528732 0.571428571428571 30.4 30 4 increased vasoconstriction 0.0888059530859291 0.251548380058473 0.847896575528732 0.571428571428571 30.4 30 4 abnormal stapes morphology 0.0888059530859291 0.251548380058473 0.847896575528732 0.571428571428571 30.4 30 4 increased sensitivity to induced morbidity/mortality 2.93644641725628e-06 5.91450239912955e-05 0.846744542138068 0.570652173913043 30.4 30 4 abnormal heart left ventricle morphology 0.0030751792689176 0.0207867076941101 0.844952490197036 0.569444444444444 30.4 30 4 abnormal vertebrae morphology 0.000328493420880517 0.00344053635553805 0.844007141696032 0.568807339449541 30.4 30 4 abnormal cervical vertebrae morphology 0.0120984760988354 0.0591256567698489 0.843740219766337 0.568627450980392 30.4 30 4 abnormal gluconeogenesis 0.0120984760988354 0.0591256567698489 0.843740219766337 0.568627450980392 30.4 30 4 increased kidney weight 0.0120984760988354 0.0591256567698489 0.843740219766337 0.568627450980392 30.4 30 4 increased brown adipose tissue amount 0.0312220357715303 0.118391484728173 0.842167544612998 0.567567567567568 30.4 30 4 increased circulating phosphate level 0.0312220357715303 0.118391484728173 0.842167544612998 0.567567567567568 30.4 30 4 decreased cardiac muscle contractility 0.00049638338387876 0.00484217124469967 0.8417819367629 0.567307692307692 30.4 30 4 increased total body fat amount 8.50116265376166e-05 0.00109568093788767 0.84156898914419 0.567164179104478 30.4 30 4 salivary gland inflammation 0.0510831357232343 0.174379864276682 0.84083077073266 0.566666666666667 30.4 30 4 abnormal synaptic transmission 0.0510831357232343 0.174379864276682 0.84083077073266 0.566666666666667 30.4 30 4 abnormal locomotor behavior 0.00116578015616495 0.00965017683347859 0.83868030840342 0.565217391304348 30.4 30 4 abnormal blood vessel physiology 0.0852740848620289 0.249698983042139 0.83868030840342 0.565217391304348 30.4 30 4 abnormal pulmonary artery morphology 0.0852740848620289 0.249698983042139 0.83868030840342 0.565217391304348 30.4 30 4 abnormal carpal bone morphology 0.0852740848620289 0.249698983042139 0.83868030840342 0.565217391304348 30.4 30 4 abnormal cranial nerve morphology 0.0852740848620289 0.249698983042139 0.83868030840342 0.565217391304348 30.4 30 4 blistering 0.0852740848620289 0.249698983042139 0.83868030840342 0.565217391304348 30.4 30 4 bidirectional circling 0.0852740848620289 0.249698983042139 0.83868030840342 0.565217391304348 30.4 30 4 abnormal sacral vertebrae morphology 0.0852740848620289 0.249698983042139 0.83868030840342 0.565217391304348 30.4 30 4 abnormal excitatory postsynaptic currents 0.00283531904112446 0.0196458387598805 0.837026106611698 0.564102564102564 30.4 30 4 abnormal leukocyte adhesion 0.0301987960365862 0.115821002810488 0.837026106611698 0.564102564102564 30.4 30 4 increased autoantibody level 0.0301987960365862 0.115821002810488 0.837026106611698 0.564102564102564 30.4 30 4 abnormal learning/memory/conditioning 0.0113973898064255 0.0558640534846962 0.836334349498795 0.563636363636364 30.4 30 4 abnormal retinal pigmentation 0.00176565725591612 0.0132202010511773 0.835714153466538 0.563218390804598 30.4 30 4 reduced long term potentiation 0.000446656738813453 0.00442652843744409 0.834648191536096 0.5625 30.4 30 4 abnormal neuron differentiation 0.000446656738813453 0.00442652843744409 0.834648191536096 0.5625 30.4 30 4 abnormal kidney physiology 0.0181577762853342 0.0816033758080738 0.834648191536096 0.5625 30.4 30 4 abnormal osteoclast morphology 0.0181577762853342 0.0816033758080738 0.834648191536096 0.5625 30.4 30 4 abnormal crypts of Lieberkuhn morphology 0.0492411920437312 0.171191425868318 0.834648191536096 0.5625 30.4 30 4 kidney cortex cysts 0.0492411920437312 0.171191425868318 0.834648191536096 0.5625 30.4 30 4 abnormal bone marrow cell number 0.147189488799922 0.366014218333132 0.834648191536096 0.5625 30.4 30 4 vasculature congestion 0.147189488799922 0.366014218333132 0.834648191536096 0.5625 30.4 30 4 mixed cellular infiltration to dermis 0.147189488799922 0.366014218333132 0.834648191536096 0.5625 30.4 30 4 reduced male mating frequency 0.147189488799922 0.366014218333132 0.834648191536096 0.5625 30.4 30 4 intraventricular hemorrhage 0.147189488799922 0.366014218333132 0.834648191536096 0.5625 30.4 30 4 small pancreas 0.147189488799922 0.366014218333132 0.834648191536096 0.5625 30.4 30 4 bowed radius 0.147189488799922 0.366014218333132 0.834648191536096 0.5625 30.4 30 4 abnormal amnion morphology 0.147189488799922 0.366014218333132 0.834648191536096 0.5625 30.4 30 4 decreased circulating growth hormone level 0.147189488799922 0.366014218333132 0.834648191536096 0.5625 30.4 30 4 impaired behavioral response to addictive substance 0.147189488799922 0.366014218333132 0.834648191536096 0.5625 30.4 30 4 dilated respiratory conducting tubes 0.147189488799922 0.366014218333132 0.834648191536096 0.5625 30.4 30 4 decreased midbrain size 0.147189488799922 0.366014218333132 0.834648191536096 0.5625 30.4 30 4 increased startle reflex 0.00171597797194919 0.0131947301552507 0.833606183806338 0.561797752808989 30.4 30 4 impaired swimming 0.00677592096803064 0.0380047427462824 0.831837928264931 0.560606060606061 30.4 30 4 abnormal tail morphology 0.00677592096803064 0.0380047427462824 0.831837928264931 0.560606060606061 30.4 30 4 abnormal axon extension 0.0175647432792155 0.0790810839946582 0.830938644018158 0.56 30.4 30 4 decreased oocyte number 0.0175647432792155 0.0790810839946582 0.830938644018158 0.56 30.4 30 4 abnormal nest building behavior 0.0817561184630501 0.24053027164617 0.830938644018158 0.56 30.4 30 4 abnormal feces composition 0.0817561184630501 0.24053027164617 0.830938644018158 0.56 30.4 30 4 abnormal retinal photoreceptor morphology 0.0474050557539427 0.16503859508458 0.829192974597952 0.558823529411765 30.4 30 4 abnormal vision 0.0474050557539427 0.16503859508458 0.829192974597952 0.558823529411765 30.4 30 4 decreased cytotoxic T cell cytolysis 0.0474050557539427 0.16503859508458 0.829192974597952 0.558823529411765 30.4 30 4 abnormal blood circulation 0.0281511373604579 0.10865159687221 0.828178050516436 0.558139534883721 30.4 30 4 decreased oxygen consumption 0.0281511373604579 0.10865159687221 0.828178050516436 0.558139534883721 30.4 30 4 decreased IgA level 0.0169757302734411 0.076567777071958 0.827514446309292 0.557692307692308 30.4 30 4 abnormal leukocyte migration 0.0169757302734411 0.076567777071958 0.827514446309292 0.557692307692308 30.4 30 4 hyperglycemia 0.00244072580952536 0.0171505803706055 0.8262174017226 0.556818181818182 30.4 30 4 decreased neutrophil cell number 0.000579202340549354 0.0055096207346712 0.824343892875157 0.555555555555556 30.4 30 4 increased susceptibility to bacterial infection induced morbidity/mortality 0.00615139436896545 0.0350123108153227 0.824343892875157 0.555555555555556 30.4 30 4 altered response to myocardial infarction 0.0271409103007635 0.104915329251203 0.824343892875157 0.555555555555556 30.4 30 4 impaired wound healing 0.0455900988900076 0.159053816253708 0.824343892875157 0.555555555555556 30.4 30 4 abnormal pharyngeal arch morphology 0.0455900988900076 0.159053816253708 0.824343892875157 0.555555555555556 30.4 30 4 lowered ear position 0.139732008385216 0.356861777061832 0.824343892875157 0.555555555555556 30.4 30 4 abnormal heart shape 0.139732008385216 0.356861777061832 0.824343892875157 0.555555555555556 30.4 30 4 cortical renal glomerulopathies 0.139732008385216 0.356861777061832 0.824343892875157 0.555555555555556 30.4 30 4 right pulmonary isomerism 0.139732008385216 0.356861777061832 0.824343892875157 0.555555555555556 30.4 30 4 abnormal retinal rod cell morphology 0.139732008385216 0.356861777061832 0.824343892875157 0.555555555555556 30.4 30 4 thick dermal layer 0.139732008385216 0.356861777061832 0.824343892875157 0.555555555555556 30.4 30 4 abnormal iron level 0.139732008385216 0.356861777061832 0.824343892875157 0.555555555555556 30.4 30 4 abnormal redox activity 0.139732008385216 0.356861777061832 0.824343892875157 0.555555555555556 30.4 30 4 decreased activity of thyroid 0.139732008385216 0.356861777061832 0.824343892875157 0.555555555555556 30.4 30 4 decreased lactate dehydrogenase level 0.139732008385216 0.356861777061832 0.824343892875157 0.555555555555556 30.4 30 4 abnormal macrophage chemotaxis 0.139732008385216 0.356861777061832 0.824343892875157 0.555555555555556 30.4 30 4 crypts of Lieberkuhn abscesses 0.272013631576204 0.529033548511186 0.824343892875157 0.555555555555556 30.4 30 4 synostosis 0.272013631576204 0.529033548511186 0.824343892875157 0.555555555555556 30.4 30 4 absent enteric neurons 0.272013631576204 0.529033548511186 0.824343892875157 0.555555555555556 30.4 30 4 dilated uterus 0.272013631576204 0.529033548511186 0.824343892875157 0.555555555555556 30.4 30 4 psoriasis 0.272013631576204 0.529033548511186 0.824343892875157 0.555555555555556 30.4 30 4 abnormal lens vesicle development 0.272013631576204 0.529033548511186 0.824343892875157 0.555555555555556 30.4 30 4 abnormal kindling response 0.272013631576204 0.529033548511186 0.824343892875157 0.555555555555556 30.4 30 4 multifocal hepatic necrosis 0.272013631576204 0.529033548511186 0.824343892875157 0.555555555555556 30.4 30 4 abnormal ion homeostasis 0.272013631576204 0.529033548511186 0.824343892875157 0.555555555555556 30.4 30 4 increased pheochromocytoma incidence 0.272013631576204 0.529033548511186 0.824343892875157 0.555555555555556 30.4 30 4 abnormal gut-associated lymphoid tissue morphology 0.272013631576204 0.529033548511186 0.824343892875157 0.555555555555556 30.4 30 4 polycythemia 0.272013631576204 0.529033548511186 0.824343892875157 0.555555555555556 30.4 30 4 abnormal postural reflex 0.272013631576204 0.529033548511186 0.824343892875157 0.555555555555556 30.4 30 4 decreased circulating bicarbonate level 0.272013631576204 0.529033548511186 0.824343892875157 0.555555555555556 30.4 30 4 genetic imprinting 0.272013631576204 0.529033548511186 0.824343892875157 0.555555555555556 30.4 30 4 enlarged otoliths 0.272013631576204 0.529033548511186 0.824343892875157 0.555555555555556 30.4 30 4 absent posterior semicircular canal 0.272013631576204 0.529033548511186 0.824343892875157 0.555555555555556 30.4 30 4 abnormal artery development 0.272013631576204 0.529033548511186 0.824343892875157 0.555555555555556 30.4 30 4 premature neuronal precursor differentiation 0.272013631576204 0.529033548511186 0.824343892875157 0.555555555555556 30.4 30 4 decreased susceptibility to induced choroidal neovascularization 0.272013631576204 0.529033548511186 0.824343892875157 0.555555555555556 30.4 30 4 decreased fear-related response 0.272013631576204 0.529033548511186 0.824343892875157 0.555555555555556 30.4 30 4 abnormal stria vascularis vasculature morphology 0.272013631576204 0.529033548511186 0.824343892875157 0.555555555555556 30.4 30 4 short frontal bone 0.272013631576204 0.529033548511186 0.824343892875157 0.555555555555556 30.4 30 4 absent cochlear outer hair cells 0.272013631576204 0.529033548511186 0.824343892875157 0.555555555555556 30.4 30 4 abnormal hair cell mechanoelectric transduction 0.272013631576204 0.529033548511186 0.824343892875157 0.555555555555556 30.4 30 4 abnormal CNS synapse formation 0.272013631576204 0.529033548511186 0.824343892875157 0.555555555555556 30.4 30 4 abnormal intervertebral disk development 0.272013631576204 0.529033548511186 0.824343892875157 0.555555555555556 30.4 30 4 decreased susceptibility to atherosclerosis 0.272013631576204 0.529033548511186 0.824343892875157 0.555555555555556 30.4 30 4 abnormal leukopoiesis 0.272013631576204 0.529033548511186 0.824343892875157 0.555555555555556 30.4 30 4 absent cervical lymph nodes 0.272013631576204 0.529033548511186 0.824343892875157 0.555555555555556 30.4 30 4 abnormal optic chiasm morphology 0.272013631576204 0.529033548511186 0.824343892875157 0.555555555555556 30.4 30 4 abnormal hyoid bone lesser horn morphology 0.272013631576204 0.529033548511186 0.824343892875157 0.555555555555556 30.4 30 4 abnormal hippocampus granule cell morphology 0.272013631576204 0.529033548511186 0.824343892875157 0.555555555555556 30.4 30 4 abnormal ventricle myocardium morphology 0.272013631576204 0.529033548511186 0.824343892875157 0.555555555555556 30.4 30 4 decreased susceptibility to parasitic infection induced morbidity/mortality 0.272013631576204 0.529033548511186 0.824343892875157 0.555555555555556 30.4 30 4 abnormal heart left ventricle pressure 0.272013631576204 0.529033548511186 0.824343892875157 0.555555555555556 30.4 30 4 abnormal pulmonary alveolar parenchyma morphology 0.272013631576204 0.529033548511186 0.824343892875157 0.555555555555556 30.4 30 4 reduced AMPA-mediated synaptic currents 0.272013631576204 0.529033548511186 0.824343892875157 0.555555555555556 30.4 30 4 decreased bone mineral density of femur 0.272013631576204 0.529033548511186 0.824343892875157 0.555555555555556 30.4 30 4 adipose tissue inflammation 0.272013631576204 0.529033548511186 0.824343892875157 0.555555555555556 30.4 30 4 cryptorchism 0.0782943192836976 0.230891664751864 0.824343892875157 0.555555555555556 30.4 30 4 abnormal trabecular bone morphology 0.000561508917698504 0.00536181740028801 0.822958440954358 0.554621848739496 30.4 30 4 abnormal innervation 0.0261465900561175 0.101615122081211 0.820836046522496 0.553191489361702 30.4 30 4 cochlear ganglion degeneration 0.0152571299449035 0.0700870004394226 0.818658762579466 0.551724137931034 30.4 30 4 abnormal middle ear morphology 0.074916003525841 0.221191167680154 0.818658762579466 0.551724137931034 30.4 30 4 aphagia 0.074916003525841 0.221191167680154 0.818658762579466 0.551724137931034 30.4 30 4 polychromatophilia 0.074916003525841 0.221191167680154 0.818658762579466 0.551724137931034 30.4 30 4 improved glucose tolerance 1.82156541239611e-05 0.000289529965708328 0.817614554974135 0.551020408163265 30.4 30 4 cardiac hypertrophy 0.00207361996511009 0.0149794691193543 0.817614554974135 0.551020408163265 30.4 30 4 increased circulating LDL cholesterol level 0.0251718173971959 0.101615122081211 0.817614554974135 0.551020408163265 30.4 30 4 abnormal food intake 0.00900850182623884 0.0468800173488894 0.817175685111025 0.550724637681159 30.4 30 4 abnormal social investigation 0.0053647897715206 0.0319638672015748 0.816100453946405 0.55 30.4 30 4 abnormal female reproductive system morphology 0.0420652134634943 0.147293777517645 0.816100453946405 0.55 30.4 30 4 impaired ovarian folliculogenesis 0.0420652134634943 0.147293777517645 0.816100453946405 0.55 30.4 30 4 abnormal skin pigmentation 0.0420652134634943 0.147293777517645 0.816100453946405 0.55 30.4 30 4 abnormal basioccipital bone morphology 0.132605683631956 0.340760989705051 0.816100453946405 0.55 30.4 30 4 abnormal vascular regression 0.132605683631956 0.340760989705051 0.816100453946405 0.55 30.4 30 4 abnormal fibula morphology 0.132605683631956 0.340760989705051 0.816100453946405 0.55 30.4 30 4 abnormal thymocyte activation 0.132605683631956 0.340760989705051 0.816100453946405 0.55 30.4 30 4 abnormal heart right ventricle morphology 0.132605683631956 0.340760989705051 0.816100453946405 0.55 30.4 30 4 abnormal incus morphology 0.132605683631956 0.340760989705051 0.816100453946405 0.55 30.4 30 4 decreased circulating VLDL cholesterol level 0.132605683631956 0.340760989705051 0.816100453946405 0.55 30.4 30 4 abnormal induced retinal neovascularization 0.132605683631956 0.340760989705051 0.816100453946405 0.55 30.4 30 4 abnormal sperm mitochondrial sheath morphology 0.132605683631956 0.340760989705051 0.816100453946405 0.55 30.4 30 4 increased bone mineral density 0.00117197155554794 0.00968531310440369 0.814130782697942 0.548672566371681 30.4 30 4 abnormal object recognition memory 0.0716384794353428 0.211891459685393 0.813707197483219 0.548387096774194 30.4 30 4 abnormal muscle morphology 0.0403689337347583 0.145638466519523 0.812567551548369 0.547619047619048 30.4 30 4 abnormal myocardial fiber morphology 0.00289360799633682 0.0199975690749297 0.810746467838041 0.54639175257732 30.4 30 4 abnormal tooth development 0.0684722489576288 0.202767522954883 0.809355822095608 0.545454545454545 30.4 30 4 abnormal ovarian folliculogenesis 0.0684722489576288 0.202767522954883 0.809355822095608 0.545454545454545 30.4 30 4 dilated heart atrium 0.0684722489576288 0.202767522954883 0.809355822095608 0.545454545454545 30.4 30 4 abnormal T-helper 2 physiology 0.0223886826662952 0.0938954221309907 0.809355822095608 0.545454545454545 30.4 30 4 hypertension 0.0387224828095801 0.140003162774463 0.809355822095608 0.545454545454545 30.4 30 4 abnormal photoreceptor outer segment morphology 0.0387224828095801 0.140003162774463 0.809355822095608 0.545454545454545 30.4 30 4 increased body size 0.125830503650758 0.325705908253134 0.809355822095608 0.545454545454545 30.4 30 4 increased activated T cell number 0.125830503650758 0.325705908253134 0.809355822095608 0.545454545454545 30.4 30 4 increased coping response 0.125830503650758 0.325705908253134 0.809355822095608 0.545454545454545 30.4 30 4 abnormal tracheal cartilage morphology 0.125830503650758 0.325705908253134 0.809355822095608 0.545454545454545 30.4 30 4 abnormal blood-brain barrier function 0.125830503650758 0.325705908253134 0.809355822095608 0.545454545454545 30.4 30 4 abnormal temporal bone morphology 0.125830503650758 0.325705908253134 0.809355822095608 0.545454545454545 30.4 30 4 decreased susceptibility to viral infection induced morbidity/mortality 0.125830503650758 0.325705908253134 0.809355822095608 0.545454545454545 30.4 30 4 increased bone volume 0.125830503650758 0.325705908253134 0.809355822095608 0.545454545454545 30.4 30 4 impaired humoral immune response 0.125830503650758 0.325705908253134 0.809355822095608 0.545454545454545 30.4 30 4 abnormal ear position 0.252252556470963 0.49906752420402 0.809355822095608 0.545454545454545 30.4 30 4 increased mast cell number 0.252252556470963 0.49906752420402 0.809355822095608 0.545454545454545 30.4 30 4 enlarged cranium 0.252252556470963 0.49906752420402 0.809355822095608 0.545454545454545 30.4 30 4 abnormal glossopharyngeal ganglion morphology 0.252252556470963 0.49906752420402 0.809355822095608 0.545454545454545 30.4 30 4 abnormal food preference 0.252252556470963 0.49906752420402 0.809355822095608 0.545454545454545 30.4 30 4 failure of somite differentiation 0.252252556470963 0.49906752420402 0.809355822095608 0.545454545454545 30.4 30 4 abnormal hypothalamus secretion 0.252252556470963 0.49906752420402 0.809355822095608 0.545454545454545 30.4 30 4 vasculitis 0.252252556470963 0.49906752420402 0.809355822095608 0.545454545454545 30.4 30 4 increased motor neuron number 0.252252556470963 0.49906752420402 0.809355822095608 0.545454545454545 30.4 30 4 aberrant origin of the right subclavian artery 0.252252556470963 0.49906752420402 0.809355822095608 0.545454545454545 30.4 30 4 abnormal extraembryonic ectoderm morphology 0.252252556470963 0.49906752420402 0.809355822095608 0.545454545454545 30.4 30 4 decreased anxiety-related response 0.000985215583672943 0.00839288960406317 0.808259133989788 0.544715447154472 30.4 30 4 increased susceptibility to pharmacologically induced seizures 0.00400750405039145 0.0253655631688263 0.803735295553278 0.541666666666667 30.4 30 4 abnormal urine homeostasis 0.00400750405039145 0.0253655631688263 0.803735295553278 0.541666666666667 30.4 30 4 abnormal hair shaft morphology 0.0355879154215888 0.13144014790082 0.803735295553278 0.541666666666667 30.4 30 4 abnormal adrenal gland morphology 0.119408118151991 0.310536010353454 0.803735295553278 0.541666666666667 30.4 30 4 curly vibrissae 0.119408118151991 0.310536010353454 0.803735295553278 0.541666666666667 30.4 30 4 abnormal vasodilation 0.119408118151991 0.310536010353454 0.803735295553278 0.541666666666667 30.4 30 4 abnormal sensory capabilities/reflexes/nociception 0.119408118151991 0.310536010353454 0.803735295553278 0.541666666666667 30.4 30 4 increased circulating total protein level 0.119408118151991 0.310536010353454 0.803735295553278 0.541666666666667 30.4 30 4 abnormal T cell activation 0.011240315097951 0.0551484887695329 0.802064328202855 0.540540540540541 30.4 30 4 abnormal humerus morphology 0.0624937025588046 0.193572291681701 0.802064328202855 0.540540540540541 30.4 30 4 decreased respiratory quotient 0.0341018609269987 0.127369938522386 0.801262263874652 0.54 30.4 30 4 small ovary 0.00595630758343248 0.0342573759856377 0.798979465402075 0.538461538461538 30.4 30 4 increased rib number 0.0103828036990784 0.052497140144515 0.798979465402075 0.538461538461538 30.4 30 4 abnormal skin condition 0.0326701950733316 0.123506246572815 0.798979465402075 0.538461538461538 30.4 30 4 abnormal female meiosis 0.0326701950733316 0.123506246572815 0.798979465402075 0.538461538461538 30.4 30 4 increased vascular permeability 0.0596842807114255 0.192390304732296 0.798979465402075 0.538461538461538 30.4 30 4 abnormal response to injury 0.0596842807114255 0.192390304732296 0.798979465402075 0.538461538461538 30.4 30 4 abnormal mast cell morphology 0.234824403927044 0.468612679316904 0.798979465402075 0.538461538461538 30.4 30 4 abnormal tail bud morphology 0.234824403927044 0.468612679316904 0.798979465402075 0.538461538461538 30.4 30 4 absent lateral semicircular canal 0.234824403927044 0.468612679316904 0.798979465402075 0.538461538461538 30.4 30 4 abnormal GABAergic neuron morphology 0.234824403927044 0.468612679316904 0.798979465402075 0.538461538461538 30.4 30 4 vestibular hair cell degeneration 0.234824403927044 0.468612679316904 0.798979465402075 0.538461538461538 30.4 30 4 hyperalgesia 0.234824403927044 0.468612679316904 0.798979465402075 0.538461538461538 30.4 30 4 abnormal cochlea morphology 0.0312924810684975 0.118478001001351 0.796865763112651 0.537037037037037 30.4 30 4 lethality at weaning, incomplete penetrance 0.056993620602404 0.188526105383617 0.796195564825761 0.536585365853659 30.4 30 4 abnormal spleen germinal center morphology 0.107584116431309 0.281108707587061 0.794903039558187 0.535714285714286 30.4 30 4 abnormal retinal inner nuclear layer morphology 0.107584116431309 0.281108707587061 0.794903039558187 0.535714285714286 30.4 30 4 abnormal hormone level 0.107584116431309 0.281108707587061 0.794903039558187 0.535714285714286 30.4 30 4 decreased circulating progesterone level 0.107584116431309 0.281108707587061 0.794903039558187 0.535714285714286 30.4 30 4 abnormal intestinal mucosa morphology 0.0544193995652036 0.184049294926504 0.793670631744918 0.534883720930233 30.4 30 4 abnormal axon guidance 0.0544193995652036 0.184049294926504 0.793670631744918 0.534883720930233 30.4 30 4 dermatitis 0.0286955061513793 0.110666777599312 0.793075676248858 0.53448275862069 30.4 30 4 abnormal hair cycle 0.10215356672882 0.268792235644317 0.79137013716015 0.533333333333333 30.4 30 4 increased metastatic potential 0.10215356672882 0.268792235644317 0.79137013716015 0.533333333333333 30.4 30 4 abnormal lactation 0.10215356672882 0.268792235644317 0.79137013716015 0.533333333333333 30.4 30 4 abnormal fontanelle morphology 0.219254210977071 0.439303141204561 0.79137013716015 0.533333333333333 30.4 30 4 interdigital webbing 0.219254210977071 0.439303141204561 0.79137013716015 0.533333333333333 30.4 30 4 hyperpigmentation 0.219254210977071 0.439303141204561 0.79137013716015 0.533333333333333 30.4 30 4 no suckling reflex 0.219254210977071 0.439303141204561 0.79137013716015 0.533333333333333 30.4 30 4 joint inflammation 0.219254210977071 0.439303141204561 0.79137013716015 0.533333333333333 30.4 30 4 abnormal Muller cell morphology 0.219254210977071 0.439303141204561 0.79137013716015 0.533333333333333 30.4 30 4 ostium primum atrial septal defect 0.219254210977071 0.439303141204561 0.79137013716015 0.533333333333333 30.4 30 4 abnormal lymphatic vessel morphology 0.0970220718125028 0.267508632300152 0.788278847561868 0.53125 30.4 30 4 abnormal diaphragm morphology 0.0970220718125028 0.267508632300152 0.788278847561868 0.53125 30.4 30 4 decreased susceptibility to parasitic infection 0.0970220718125028 0.267508632300152 0.788278847561868 0.53125 30.4 30 4 increased exploration in new environment 0.0130946553689013 0.0620799491921768 0.78770638652515 0.530864197530864 30.4 30 4 abnormal glutamate-mediated receptor currents 0.205210218876487 0.412493268246676 0.785551239092796 0.529411764705882 30.4 30 4 nephrocalcinosis 0.205210218876487 0.412493268246676 0.785551239092796 0.529411764705882 30.4 30 4 aminoaciduria 0.205210218876487 0.412493268246676 0.785551239092796 0.529411764705882 30.4 30 4 impaired fertilization 0.0220786340330955 0.0930857663683476 0.784304332364077 0.528571428571429 30.4 30 4 abnormal nail morphology 0.19244905522031 0.38731150878683 0.780957372197517 0.526315789473684 30.4 30 4 altered susceptibility to infection 0.19244905522031 0.38731150878683 0.780957372197517 0.526315789473684 30.4 30 4 abnormal ear morphology 0.19244905522031 0.38731150878683 0.780957372197517 0.526315789473684 30.4 30 4 abnormal response to novelty 0.19244905522031 0.38731150878683 0.780957372197517 0.526315789473684 30.4 30 4 shortened RR interval 0.19244905522031 0.38731150878683 0.780957372197517 0.526315789473684 30.4 30 4 abnormal CNS synaptic transmission 0.00893949501571495 0.0467489476932515 0.779379680536512 0.525252525252525 30.4 30 4 abnormal pancreatic beta cell morphology 0.0791579866170333 0.233162216352718 0.779004978767023 0.525 30.4 30 4 decreased inflammatory response 0.0162373254352286 0.0733702943144978 0.777238527568005 0.523809523809524 30.4 30 4 abnormal optic nerve morphology 0.075280776156814 0.222136335338167 0.777238527568005 0.523809523809524 30.4 30 4 abnormal eye pigmentation 0.180785387232585 0.369226837775464 0.777238527568005 0.523809523809524 30.4 30 4 increased incidence of induced tumors 0.180785387232585 0.369226837775464 0.777238527568005 0.523809523809524 30.4 30 4 abnormal associative learning 0.180785387232585 0.369226837775464 0.777238527568005 0.523809523809524 30.4 30 4 abnormal clavicle morphology 0.180785387232585 0.369226837775464 0.777238527568005 0.523809523809524 30.4 30 4 abnormal bile salt homeostasis 0.180785387232585 0.369226837775464 0.777238527568005 0.523809523809524 30.4 30 4 increased bone ossification 0.180785387232585 0.369226837775464 0.777238527568005 0.523809523809524 30.4 30 4 decreased vocalization 0.180785387232585 0.369226837775464 0.777238527568005 0.523809523809524 30.4 30 4 decreased monocyte cell number 0.0327383040782715 0.12366975154852 0.776151480676301 0.523076923076923 30.4 30 4 increased liver weight 0.0148724889782344 0.0683832094886472 0.775632662841625 0.522727272727273 30.4 30 4 abnormal femur morphology 0.0312691904507247 0.118478001001351 0.77512933210649 0.522388059701492 30.4 30 4 fragile skeleton 0.1700738696021 0.369226837775464 0.774166438526234 0.521739130434783 30.4 30 4 dilated heart 0.1700738696021 0.369226837775464 0.774166438526234 0.521739130434783 30.4 30 4 abnormal palatal shelf fusion at midline 0.1700738696021 0.369226837775464 0.774166438526234 0.521739130434783 30.4 30 4 abnormal vertebrae development 0.160197784481677 0.366014218333132 0.771585883731147 0.52 30.4 30 4 abnormal preimplantation embryo development 0.160197784481677 0.366014218333132 0.771585883731147 0.52 30.4 30 4 obese 0.0248804035121813 0.101615122081211 0.770815068662484 0.519480519480519 30.4 30 4 abnormal hair growth 0.0587731837944021 0.192390304732296 0.770444484494858 0.519230769230769 30.4 30 4 diluted coat color 0.0559710123191187 0.187670068879443 0.769387633350146 0.518518518518518 30.4 30 4 wrinkled skin 0.1510615615816 0.366014218333132 0.769387633350146 0.518518518518518 30.4 30 4 abnormal palate morphology 0.1510615615816 0.366014218333132 0.769387633350146 0.518518518518518 30.4 30 4 enhanced long term potentiation 0.0533131043030556 0.18055322934493 0.768406271572914 0.517857142857143 30.4 30 4 abnormal circulating glucose level 0.142585665972882 0.363776250366713 0.767492589918249 0.517241379310345 30.4 30 4 abnormal cranial ganglia morphology 0.134702993175197 0.345971807458236 0.7658420682195 0.516129032258065 30.4 30 4 absent vibrissae 0.127356258595807 0.329141499487864 0.764391609756963 0.515151515151515 30.4 30 4 diarrhea 0.127356258595807 0.329141499487864 0.764391609756963 0.515151515151515 30.4 30 4 head tossing 0.127356258595807 0.329141499487864 0.764391609756963 0.515151515151515 30.4 30 4 abnormal inhibitory postsynaptic currents 0.0399675777969598 0.144295137547079 0.763730371340219 0.514705882352941 30.4 30 4 decreased susceptibility to injury 0.0399675777969598 0.144295137547079 0.763730371340219 0.514705882352941 30.4 30 4 abnormal action potential 0.0381155147362036 0.138109749317271 0.763106917975859 0.514285714285714 30.4 30 4 abnormal neuromuscular synapse morphology 0.0363546419411389 0.133973587894197 0.76251810090952 0.513888888888889 30.4 30 4 increased white adipose tissue amount 0.114079431455149 0.297611521494161 0.761961111792712 0.513513513513513 30.4 30 4 increased insulin secretion 0.114079431455149 0.297611521494161 0.761961111792712 0.513513513513513 30.4 30 4 abnormal male reproductive system morphology 0.0971355516337395 0.267508632300152 0.7591632129734 0.511627906976744 30.4 30 4 cardiomyopathy 0.0921572601932777 0.259686744633661 0.758396381445144 0.511111111111111 30.4 30 4 increased systemic arterial blood pressure 0.0874720404396538 0.251548380058473 0.757694812174612 0.51063829787234 30.4 30 4 abnormal cued conditioning behavior 0.0788975885560855 0.232532880963581 0.756456748756026 0.509803921568627 30.4 30 4 abnormal contextual conditioning behavior 0.0712645827576714 0.210910945401199 0.755398767289234 0.509090909090909 30.4 30 4 abnormal male meiosis 0.0613181657598192 0.193572291681701 0.754071954466127 0.508196721311475 30.4 30 4 abnormal immune system physiology 0.0110462976331017 0.0547909578511275 0.753875785903571 0.508064516129032 30.4 30 4 abnormal reproductive system physiology 0.144902692254074 0.366014218333132 0.741909503587641 0.5 30.4 30 4 hyporesponsive to tactile stimuli 0.144902692254074 0.366014218333132 0.741909503587641 0.5 30.4 30 4 increased susceptibility to parasitic infection 0.0385536356330303 0.139595587535899 0.741909503587641 0.5 30.4 30 4 decreased body temperature 0.0990219933177689 0.268027430226279 0.741909503587641 0.5 30.4 30 4 abnormal digestive system physiology 0.10438868070821 0.273333519222812 0.741909503587641 0.5 30.4 30 4 abnormal immune system morphology 0.116177519698918 0.302926184749537 0.741909503587641 0.5 30.4 30 4 skin edema 0.129580365707975 0.334541940527855 0.741909503587641 0.5 30.4 30 4 abnormal vibrissa morphology 0.129580365707975 0.334541940527855 0.741909503587641 0.5 30.4 30 4 impaired synaptic plasticity 0.162539675879838 0.366014218333132 0.741909503587641 0.5 30.4 30 4 abnormal bone remodeling 0.162539675879838 0.366014218333132 0.741909503587641 0.5 30.4 30 4 increased width of hypertrophic chondrocyte zone 0.162539675879838 0.366014218333132 0.741909503587641 0.5 30.4 30 4 abnormal skin physiology 0.162539675879838 0.366014218333132 0.741909503587641 0.5 30.4 30 4 delayed eyelid opening 0.183017765216943 0.369226837775464 0.741909503587641 0.5 30.4 30 4 abnormal response to new environment 0.183017765216943 0.369226837775464 0.741909503587641 0.5 30.4 30 4 emphysema 0.183017765216943 0.369226837775464 0.741909503587641 0.5 30.4 30 4 abnormal pain threshold 0.183017765216943 0.369226837775464 0.741909503587641 0.5 30.4 30 4 abnormal spleen marginal zone morphology 0.183017765216943 0.369226837775464 0.741909503587641 0.5 30.4 30 4 abnormal stomach morphology 0.207065170054741 0.416053804936323 0.741909503587641 0.5 30.4 30 4 abnormal cell proliferation 0.252292426808665 0.49906752420402 0.741909503587641 0.5 30.4 30 4 abnormal hearing physiology 0.252292426808665 0.49906752420402 0.741909503587641 0.5 30.4 30 4 abnormal trachea morphology 0.252292426808665 0.49906752420402 0.741909503587641 0.5 30.4 30 4 abnormal postnatal subventricular zone morphology 0.252292426808665 0.49906752420402 0.741909503587641 0.5 30.4 30 4 dilated vasculature 0.252292426808665 0.49906752420402 0.741909503587641 0.5 30.4 30 4 increased susceptibility to autoimmune disorder 0.270688429367758 0.529033548511186 0.741909503587641 0.5 30.4 30 4 decreased fluid intake 0.270688429367758 0.529033548511186 0.741909503587641 0.5 30.4 30 4 abnormal interparietal bone morphology 0.314725318414569 0.574079672772842 0.741909503587641 0.5 30.4 30 4 absent atrioventricular cushions 0.314725318414569 0.574079672772842 0.741909503587641 0.5 30.4 30 4 absent palatine bone horizontal plate 0.373432684409006 0.574079672772842 0.741909503587641 0.5 30.4 30 4 megacephaly 0.314725318414569 0.574079672772842 0.741909503587641 0.5 30.4 30 4 increased cranium width 0.373432684409006 0.574079672772842 0.741909503587641 0.5 30.4 30 4 abnormal kidney blood vessel morphology 0.314725318414569 0.574079672772842 0.741909503587641 0.5 30.4 30 4 enlarged testis 0.373432684409006 0.574079672772842 0.741909503587641 0.5 30.4 30 4 abnormal prostate gland epithelium morphology 0.373432684409006 0.574079672772842 0.741909503587641 0.5 30.4 30 4 abnormal placing response 0.314725318414569 0.574079672772842 0.741909503587641 0.5 30.4 30 4 abnormal pituitary secretion 0.373432684409006 0.574079672772842 0.741909503587641 0.5 30.4 30 4 abnormal respiratory mechanics 0.373432684409006 0.574079672772842 0.741909503587641 0.5 30.4 30 4 abnormal PNS synaptic transmission 0.373432684409006 0.574079672772842 0.741909503587641 0.5 30.4 30 4 abnormal kidney medulla morphology 0.314725318414569 0.574079672772842 0.741909503587641 0.5 30.4 30 4 rickets 0.373432684409006 0.574079672772842 0.741909503587641 0.5 30.4 30 4 abnormal scala media morphology 0.373432684409006 0.574079672772842 0.741909503587641 0.5 30.4 30 4 abnormal uterus development 0.314725318414569 0.574079672772842 0.741909503587641 0.5 30.4 30 4 cochlear ganglion hypoplasia 0.373432684409006 0.574079672772842 0.741909503587641 0.5 30.4 30 4 abnormal imprinting 0.314725318414569 0.574079672772842 0.741909503587641 0.5 30.4 30 4 absent CD4-positive, alpha beta T cells 0.373432684409006 0.574079672772842 0.741909503587641 0.5 30.4 30 4 skeletal muscle necrosis 0.314725318414569 0.574079672772842 0.741909503587641 0.5 30.4 30 4 abnormal ear physiology 0.373432684409006 0.574079672772842 0.741909503587641 0.5 30.4 30 4 enlarged stomach 0.314725318414569 0.574079672772842 0.741909503587641 0.5 30.4 30 4 abnormal maternal decidual layer morphology 0.314725318414569 0.574079672772842 0.741909503587641 0.5 30.4 30 4 abnormal deltoid tuberosity morphology 0.373432684409006 0.574079672772842 0.741909503587641 0.5 30.4 30 4 abnormal cochlear inner hair cell physiology 0.373432684409006 0.574079672772842 0.741909503587641 0.5 30.4 30 4 abnormal iris pigmentation 0.314725318414569 0.574079672772842 0.741909503587641 0.5 30.4 30 4 abnormal corneal endothelium morphology 0.373432684409006 0.574079672772842 0.741909503587641 0.5 30.4 30 4 decreased thyroxine level 0.373432684409006 0.574079672772842 0.741909503587641 0.5 30.4 30 4 ventricular premature beat 0.373432684409006 0.574079672772842 0.741909503587641 0.5 30.4 30 4 abnormal renal reabsorbtion 0.314725318414569 0.574079672772842 0.741909503587641 0.5 30.4 30 4 decreased compact bone area 0.314725318414569 0.574079672772842 0.741909503587641 0.5 30.4 30 4 decreased ovulation rate 0.220739621052208 0.442101294176625 0.741909503587641 0.5 30.4 30 4 abnormal retinal layer morphology 0.235740270814412 0.469874938822796 0.741909503587641 0.5 30.4 30 4 decreased circulating estradiol level 0.235740270814412 0.469874938822796 0.741909503587641 0.5 30.4 30 4 abnormal sperm midpiece morphology 0.235740270814412 0.469874938822796 0.741909503587641 0.5 30.4 30 4 delayed hair appearance 0.291318933154219 0.56091886095718 0.741909503587641 0.5 30.4 30 4 poor circulation 0.291318933154219 0.56091886095718 0.741909503587641 0.5 30.4 30 4 abnormal extraembryonic endoderm formation 0.291318933154219 0.56091886095718 0.741909503587641 0.5 30.4 30 4 paternal imprinting 0.291318933154219 0.56091886095718 0.741909503587641 0.5 30.4 30 4 decreased cochlear coiling 0.291318933154219 0.56091886095718 0.741909503587641 0.5 30.4 30 4 increased pancreatic beta cell number 0.291318933154219 0.56091886095718 0.741909503587641 0.5 30.4 30 4 small epididymis 0.291318933154219 0.56091886095718 0.741909503587641 0.5 30.4 30 4 abnormal epididymis epithelium morphology 0.291318933154219 0.56091886095718 0.741909503587641 0.5 30.4 30 4 abnormal wound healing 0.291318933154219 0.56091886095718 0.741909503587641 0.5 30.4 30 4 abnormal intestinal lipid absorption 0.291318933154219 0.56091886095718 0.741909503587641 0.5 30.4 30 4 abnormal Langerhans cell physiology 0.291318933154219 0.56091886095718 0.741909503587641 0.5 30.4 30 4 abnormal urinary bladder physiology 0.291318933154219 0.56091886095718 0.741909503587641 0.5 30.4 30 4 abnormal mineral level 0.34169316014369 0.574079672772842 0.741909503587641 0.5 30.4 30 4 mesocardia 0.34169316014369 0.574079672772842 0.741909503587641 0.5 30.4 30 4 abnormal glossopharyngeal nerve morphology 0.34169316014369 0.574079672772842 0.741909503587641 0.5 30.4 30 4 absent optic nerve 0.34169316014369 0.574079672772842 0.741909503587641 0.5 30.4 30 4 abnormal thymus involution 0.34169316014369 0.574079672772842 0.741909503587641 0.5 30.4 30 4 increased urine phosphate level 0.34169316014369 0.574079672772842 0.741909503587641 0.5 30.4 30 4 stria vascularis degeneration 0.34169316014369 0.574079672772842 0.741909503587641 0.5 30.4 30 4 absent cochlear hair cells 0.34169316014369 0.574079672772842 0.741909503587641 0.5 30.4 30 4 increased placenta weight 0.34169316014369 0.574079672772842 0.741909503587641 0.5 30.4 30 4 abnormal anogenital distance 0.34169316014369 0.574079672772842 0.741909503587641 0.5 30.4 30 4 hemoperitoneum 0.34169316014369 0.574079672772842 0.741909503587641 0.5 30.4 30 4 hydrometra 0.34169316014369 0.574079672772842 0.741909503587641 0.5 30.4 30 4 reduced cerebellar foliation 0.34169316014369 0.574079672772842 0.741909503587641 0.5 30.4 30 4 abnormal behavioral response to addictive substance 0.34169316014369 0.574079672772842 0.741909503587641 0.5 30.4 30 4 abnormal aorta elastic tissue morphology 0.34169316014369 0.574079672772842 0.741909503587641 0.5 30.4 30 4 decreased compensatory feeding amount 0.34169316014369 0.574079672772842 0.741909503587641 0.5 30.4 30 4 maternal effect 0.0849856488771163 0.249698983042139 0.730836227414691 0.492537313432836 30.4 30 4 decreased susceptibility to induced arthritis 0.109930267251568 0.287088230748847 0.728893547384349 0.491228070175439 30.4 30 4 decreased trabecular bone volume 0.179894997827234 0.369226837775464 0.72288618298283 0.487179487179487 30.4 30 4 abnormal pancreatic beta cell physiology 0.19065625247371 0.384481092848281 0.72185789538257 0.486486486486487 30.4 30 4 abnormal retinal photoreceptor layer morphology 0.228312864006082 0.457085110032297 0.717976938955782 0.483870967741935 30.4 30 4 increased retinal apoptosis 0.243028791440301 0.484208344980176 0.716326417257033 0.482758620689655 30.4 30 4 abnormal trigeminal nerve morphology 0.2590685207798 0.512267842161965 0.714431373825136 0.481481481481481 30.4 30 4 decreased acute inflammation 0.27662439327116 0.53737069758845 0.712233123444135 0.48 30.4 30 4 abnormal energy expenditure 0.27662439327116 0.53737069758845 0.712233123444135 0.48 30.4 30 4 impaired conditioned place preference behavior 0.27662439327116 0.53737069758845 0.712233123444135 0.48 30.4 30 4 abnormal innervation pattern to muscle 0.295934471925697 0.561722242590745 0.709652568649048 0.478260869565217 30.4 30 4 hypotension 0.295934471925697 0.561722242590745 0.709652568649048 0.478260869565217 30.4 30 4 failure of embryo implantation 0.295934471925697 0.561722242590745 0.709652568649048 0.478260869565217 30.4 30 4 increased susceptibility to age related obesity 0.295934471925697 0.561722242590745 0.709652568649048 0.478260869565217 30.4 30 4 increased susceptibility to fungal infection 0.295934471925697 0.561722242590745 0.709652568649048 0.478260869565217 30.4 30 4 dry skin 0.317298826423284 0.574079672772842 0.706580479607277 0.476190476190476 30.4 30 4 increased acute inflammation 0.317298826423284 0.574079672772842 0.706580479607277 0.476190476190476 30.4 30 4 abnormal compact bone morphology 0.231834456671383 0.463948681391846 0.702861634977765 0.473684210526316 30.4 30 4 thin dermal layer 0.341103866100461 0.574079672772842 0.702861634977765 0.473684210526316 30.4 30 4 unresponsive to tactile stimuli 0.341103866100461 0.574079672772842 0.702861634977765 0.473684210526316 30.4 30 4 abnormal neural crest cell migration 0.341103866100461 0.574079672772842 0.702861634977765 0.473684210526316 30.4 30 4 increased circulating VLDL cholesterol level 0.341103866100461 0.574079672772842 0.702861634977765 0.473684210526316 30.4 30 4 decreased eye pigmentation 0.341103866100461 0.574079672772842 0.702861634977765 0.473684210526316 30.4 30 4 Leydig cell hypoplasia 0.341103866100461 0.574079672772842 0.702861634977765 0.473684210526316 30.4 30 4 abnormal systemic arterial blood pressure 0.245950835602336 0.489638018055872 0.700692308943883 0.472222222222222 30.4 30 4 heart right ventricle hypertrophy 0.245950835602336 0.489638018055872 0.700692308943883 0.472222222222222 30.4 30 4 abnormal urinary bladder morphology 0.367860012512203 0.574079672772842 0.698267768082486 0.470588235294118 30.4 30 4 increased aggression towards mice 0.367860012512203 0.574079672772842 0.698267768082486 0.470588235294118 30.4 30 4 abnormal melanosome morphology 0.367860012512203 0.574079672772842 0.698267768082486 0.470588235294118 30.4 30 4 pancytopenia 0.367860012512203 0.574079672772842 0.698267768082486 0.470588235294118 30.4 30 4 decreased food intake 0.140689679974117 0.359123221072977 0.694953205892221 0.468354430379747 30.4 30 4 abnormal estrous cycle 0.295538439385739 0.561722242590745 0.692448870015132 0.466666666666667 30.4 30 4 abnormal prostate gland morphology 0.398262537422381 0.574079672772842 0.692448870015132 0.466666666666667 30.4 30 4 audiogenic seizures 0.398262537422381 0.574079672772842 0.692448870015132 0.466666666666667 30.4 30 4 placental labyrinth hypoplasia 0.398262537422381 0.574079672772842 0.692448870015132 0.466666666666667 30.4 30 4 abnormal cricoid cartilage morphology 0.398262537422381 0.574079672772842 0.692448870015132 0.466666666666667 30.4 30 4 increased alcohol consumption 0.398262537422381 0.574079672772842 0.692448870015132 0.466666666666667 30.4 30 4 abnormal pericyte morphology 0.398262537422381 0.574079672772842 0.692448870015132 0.466666666666667 30.4 30 4 lactation failure 0.398262537422381 0.574079672772842 0.692448870015132 0.466666666666667 30.4 30 4 decreased trabecular bone mass 0.398262537422381 0.574079672772842 0.692448870015132 0.466666666666667 30.4 30 4 abnormal eye electrophysiology 0.104374073020204 0.273333519222812 0.686726152081122 0.462809917355372 30.4 30 4 absent corpus luteum 0.232829292451782 0.465752203436918 0.684839541773207 0.461538461538462 30.4 30 4 small seminal vesicle 0.336246584599519 0.574079672772842 0.684839541773207 0.461538461538462 30.4 30 4 abnormal sympathetic ganglion morphology 0.433294951186529 0.608251236499148 0.684839541773207 0.461538461538462 30.4 30 4 small trigeminal ganglion 0.433294951186529 0.608251236499148 0.684839541773207 0.461538461538462 30.4 30 4 dystrophic cardiac calcinosis 0.433294951186529 0.608251236499148 0.684839541773207 0.461538461538462 30.4 30 4 abnormal vestibulocochlear ganglion morphology 0.433294951186529 0.608251236499148 0.684839541773207 0.461538461538462 30.4 30 4 decreased endocochlear potential 0.433294951186529 0.608251236499148 0.684839541773207 0.461538461538462 30.4 30 4 increased renin activity 0.433294951186529 0.608251236499148 0.684839541773207 0.461538461538462 30.4 30 4 abnormal gut flora balance 0.433294951186529 0.608251236499148 0.684839541773207 0.461538461538462 30.4 30 4 abnormal hair follicle inner root sheath morphology 0.433294951186529 0.608251236499148 0.684839541773207 0.461538461538462 30.4 30 4 abnormal breathing pattern 0.292951231261668 0.56091886095718 0.681754678972427 0.459459459459459 30.4 30 4 abnormal malleus morphology 0.359560884203264 0.574079672772842 0.680083711622004 0.458333333333333 30.4 30 4 abnormal cardiac muscle contractility 0.359560884203264 0.574079672772842 0.680083711622004 0.458333333333333 30.4 30 4 absent semicircular canals 0.474416124357375 0.648946994412411 0.674463185079674 0.454545454545455 30.4 30 4 abnormal sebaceous gland morphology 0.474416124357375 0.648946994412411 0.674463185079674 0.454545454545455 30.4 30 4 social withdrawal 0.474416124357375 0.648946994412411 0.674463185079674 0.454545454545455 30.4 30 4 abnormal larynx morphology 0.474416124357375 0.648946994412411 0.674463185079674 0.454545454545455 30.4 30 4 abnormal vestibular ganglion morphology 0.474416124357375 0.648946994412411 0.674463185079674 0.454545454545455 30.4 30 4 decreased post-tetanic potentiation 0.474416124357375 0.648946994412411 0.674463185079674 0.454545454545455 30.4 30 4 patent ductus arteriosus 0.474416124357375 0.648946994412411 0.674463185079674 0.454545454545455 30.4 30 4 abnormal frequency of paradoxical sleep 0.474416124357375 0.648946994412411 0.674463185079674 0.454545454545455 30.4 30 4 rectal hemorrhage 0.474416124357375 0.648946994412411 0.674463185079674 0.454545454545455 30.4 30 4 impaired luteinization 0.474416124357375 0.648946994412411 0.674463185079674 0.454545454545455 30.4 30 4 abnormal nerve fiber response 0.474416124357375 0.648946994412411 0.674463185079674 0.454545454545455 30.4 30 4 abnormal lymph circulation 0.474416124357375 0.648946994412411 0.674463185079674 0.454545454545455 30.4 30 4 enlarged placenta 0.474416124357375 0.648946994412411 0.674463185079674 0.454545454545455 30.4 30 4 abnormal Bruch membrane morphology 0.474416124357375 0.648946994412411 0.674463185079674 0.454545454545455 30.4 30 4 abnormal aorta smooth muscle morphology 0.474416124357375 0.648946994412411 0.674463185079674 0.454545454545455 30.4 30 4 abnormal brain ependyma motile cilium morphology 0.474416124357375 0.648946994412411 0.674463185079674 0.454545454545455 30.4 30 4 increased pancreatic beta cell proliferation 0.474416124357375 0.648946994412411 0.674463185079674 0.454545454545455 30.4 30 4 chylous ascites 0.474416124357375 0.648946994412411 0.674463185079674 0.454545454545455 30.4 30 4 hypolactation 0.474416124357375 0.648946994412411 0.674463185079674 0.454545454545455 30.4 30 4 decreased colon length 0.474416124357375 0.648946994412411 0.674463185079674 0.454545454545455 30.4 30 4 abnormal body temperature homeostasis 0.350900677933692 0.574079672772842 0.670111809692063 0.451612903225806 30.4 30 4 perinatal lethality 0.323506289182309 0.574079672772842 0.667718553228877 0.45 30.4 30 4 increased urine glucose level 0.413767770975567 0.582318150099984 0.667718553228877 0.45 30.4 30 4 abnormal male reproductive system physiology 0.413767770975567 0.582318150099984 0.667718553228877 0.45 30.4 30 4 nuclear cataracts 0.413767770975567 0.582318150099984 0.667718553228877 0.45 30.4 30 4 decreased urine osmolality 0.300499500615126 0.57016972370719 0.666204452201147 0.448979591836735 30.4 30 4 decreased retinal photoreceptor cell number 0.373465912518397 0.574079672772842 0.665160244595816 0.448275862068966 30.4 30 4 stomach inflammation 0.373465912518397 0.574079672772842 0.665160244595816 0.448275862068966 30.4 30 4 enlarged epididymis 0.373465912518397 0.574079672772842 0.665160244595816 0.448275862068966 30.4 30 4 increased double-positive T cell number 0.373465912518397 0.574079672772842 0.665160244595816 0.448275862068966 30.4 30 4 decreased threshold for auditory brainstem response 0.342426715453804 0.574079672772842 0.663813766367889 0.447368421052632 30.4 30 4 abnormal stomach glandular epithelium morphology 0.44559727902776 0.624815801342476 0.659475114300125 0.444444444444444 30.4 30 4 decreased heart rate variability 0.44559727902776 0.624815801342476 0.659475114300125 0.444444444444444 30.4 30 4 abnormal sperm axoneme morphology 0.44559727902776 0.624815801342476 0.659475114300125 0.444444444444444 30.4 30 4 abnormal inner ear vestibule morphology 0.424725269935632 0.597570197378329 0.652880363157124 0.44 30.4 30 4 increased dopamine level 0.407864143052814 0.580438626697309 0.649170815639186 0.4375 30.4 30 4 white spotting 0.481440896297617 0.658013312934243 0.649170815639186 0.4375 30.4 30 4 abnormal molar crown morphology 0.481440896297617 0.658013312934243 0.649170815639186 0.4375 30.4 30 4 abnormal fertilization 0.481440896297617 0.658013312934243 0.649170815639186 0.4375 30.4 30 4 abnormal crista ampullaris morphology 0.453979533665279 0.634197249856268 0.645138698771862 0.434782608695652 30.4 30 4 decreased epididymis weight 0.453979533665279 0.634197249856268 0.645138698771862 0.434782608695652 30.4 30 4 abnormal regulatory T cell physiology 0.453979533665279 0.634197249856268 0.645138698771862 0.434782608695652 30.4 30 4 impaired behavioral response to xenobiotic 0.439708725125185 0.617080650916162 0.635922431646549 0.428571428571429 30.4 30 4 abnormal stria vascularis morphology 0.460235237680776 0.634197249856268 0.635922431646549 0.428571428571429 30.4 30 4 increased circulating luteinizing hormone level 0.460235237680776 0.634197249856268 0.635922431646549 0.428571428571429 30.4 30 4 trunk curl 0.486119479389778 0.664225325450191 0.635922431646549 0.428571428571429 30.4 30 4 abnormal zigzag hair morphology 0.522222175765498 0.695715568300329 0.635922431646549 0.428571428571429 30.4 30 4 abnormal fluid regulation 0.522222175765498 0.695715568300329 0.635922431646549 0.428571428571429 30.4 30 4 abnormal olfactory system physiology 0.522222175765498 0.695715568300329 0.635922431646549 0.428571428571429 30.4 30 4 intestinal obstruction 0.522222175765498 0.695715568300329 0.635922431646549 0.428571428571429 30.4 30 4 abnormal hair cuticle 0.522222175765498 0.695715568300329 0.635922431646549 0.428571428571429 30.4 30 4 increased circulating growth hormone level 0.522222175765498 0.695715568300329 0.635922431646549 0.428571428571429 30.4 30 4 sternebra fusion 0.522222175765498 0.695715568300329 0.635922431646549 0.428571428571429 30.4 30 4 polyphagia 0.413252551121613 0.582087044685737 0.63199698453762 0.425925925925926 30.4 30 4 irregular coat pigmentation 0.521592488429431 0.695715568300329 0.624765897758013 0.421052631578947 30.4 30 4 decreased chemically-elicited antinociception 0.521592488429431 0.695715568300329 0.624765897758013 0.421052631578947 30.4 30 4 abnormal photoreceptor inner segment morphology 0.521592488429431 0.695715568300329 0.624765897758013 0.421052631578947 30.4 30 4 abnormal behavioral response to xenobiotic 0.521592488429431 0.695715568300329 0.624765897758013 0.421052631578947 30.4 30 4 decreased neuronal precursor cell number 0.49239299917095 0.672612622425995 0.622246680428344 0.419354838709677 30.4 30 4 hypopigmentation 0.521421426138146 0.695715568300329 0.618257919656367 0.416666666666667 30.4 30 4 abnormal cellular extravasation 0.521421426138146 0.695715568300329 0.618257919656367 0.416666666666667 30.4 30 4 decreased digestive secretion 0.569218241652864 0.746208366857181 0.618257919656367 0.416666666666667 30.4 30 4 abnormal enteric nervous system morphology 0.569218241652864 0.746208366857181 0.618257919656367 0.416666666666667 30.4 30 4 increased litter size 0.569218241652864 0.746208366857181 0.618257919656367 0.416666666666667 30.4 30 4 increased circulating parathyroid hormone level 0.569218241652864 0.746208366857181 0.618257919656367 0.416666666666667 30.4 30 4 increased fear-related response 0.569218241652864 0.746208366857181 0.618257919656367 0.416666666666667 30.4 30 4 decreased renal glomerular filtration rate 0.569218241652864 0.746208366857181 0.618257919656367 0.416666666666667 30.4 30 4 impaired behavioral response to cocaine 0.569218241652864 0.746208366857181 0.618257919656367 0.416666666666667 30.4 30 4 thin skin 0.521679020534945 0.695715568300329 0.610984297072175 0.411764705882353 30.4 30 4 enlarged sebaceous gland 0.560947514947407 0.736724890935415 0.610984297072175 0.411764705882353 30.4 30 4 decreased macrophage cell number 0.522277731557799 0.695715568300329 0.607016866571706 0.409090909090909 30.4 30 4 abnormal channel response 0.555942303207617 0.730344060855002 0.607016866571706 0.409090909090909 30.4 30 4 decreased susceptibility to pharmacologically induced seizures 0.552598804106803 0.726143436458359 0.604518854775115 0.407407407407407 30.4 30 4 decreased skin tensile strength 0.593475633398675 0.77049615766138 0.593527602870113 0.4 30.4 30 4 abnormal circulating cytokine level 0.593475633398675 0.77049615766138 0.593527602870113 0.4 30.4 30 4 arthritis 0.60486193466091 0.780570447646752 0.593527602870113 0.4 30.4 30 4 greasy coat 0.60486193466091 0.780570447646752 0.593527602870113 0.4 30.4 30 4 decreased aggression towards males 0.60486193466091 0.780570447646752 0.593527602870113 0.4 30.4 30 4 abnormal rostral migratory stream morphology 0.60486193466091 0.780570447646752 0.593527602870113 0.4 30.4 30 4 decreased systemic arterial blood pressure 0.605509827682822 0.780570447646752 0.584534760402384 0.393939393939394 30.4 30 4 abnormal respiration 0.612363464735409 0.780570447646752 0.582928895676004 0.392857142857143 30.4 30 4 abnormal retinal cone cell morphology 0.621489797913405 0.780570447646752 0.580624828894676 0.391304347826087 30.4 30 4 pancreas inflammation 0.621489797913405 0.780570447646752 0.580624828894676 0.391304347826087 30.4 30 4 no spontaneous movement 0.646057962205056 0.78355396440033 0.570699618144339 0.384615384615385 30.4 30 4 abnormal ocular fundus morphology 0.646057962205056 0.78355396440033 0.570699618144339 0.384615384615385 30.4 30 4 abnormal tectorial membrane morphology 0.646057962205056 0.78355396440033 0.570699618144339 0.384615384615385 30.4 30 4 abnormal renal/urinary system morphology 0.654170298194325 0.792041186059081 0.570699618144339 0.384615384615385 30.4 30 4 uterus hypoplasia 0.654170298194325 0.792041186059081 0.570699618144339 0.384615384615385 30.4 30 4 lymphoid hypoplasia 0.654170298194325 0.792041186059081 0.570699618144339 0.384615384615385 30.4 30 4 abnormal otolith morphology 0.654170298194325 0.792041186059081 0.570699618144339 0.384615384615385 30.4 30 4 increased synaptic depression 0.654170298194325 0.792041186059081 0.570699618144339 0.384615384615385 30.4 30 4 decreased alcohol consumption 0.654170298194325 0.792041186059081 0.570699618144339 0.384615384615385 30.4 30 4 abnormal insulin secretion 0.654170298194325 0.792041186059081 0.570699618144339 0.384615384615385 30.4 30 4 hypoalgesia 0.659540958942611 0.796600964569837 0.565264383685822 0.380952380952381 30.4 30 4 apnea 0.681530820978561 0.813097322390489 0.556432127690731 0.375 30.4 30 4 abnormal long term potentiation 0.687528375699187 0.819726697096417 0.556432127690731 0.375 30.4 30 4 abnormal single cell response 0.701033937556969 0.832373231347475 0.549562595250104 0.37037037037037 30.4 30 4 right-sided stomach 0.700128715092841 0.831496862637117 0.546670160538262 0.368421052631579 30.4 30 4 intestinal ulcer 0.718740190791181 0.851770473841382 0.539570548063739 0.363636363636364 30.4 30 4 abnormal stomach mucosa morphology 0.735331297000351 0.870602856396179 0.534174842583102 0.36 30.4 30 4 abnormal prepulse inhibition 0.727474810654783 0.861506113546191 0.529935359705458 0.357142857142857 30.4 30 4 abnormal glucose tolerance 0.727474810654783 0.861506113546191 0.529935359705458 0.357142857142857 30.4 30 4 increased lung compliance 0.727474810654783 0.861506113546191 0.529935359705458 0.357142857142857 30.4 30 4 distended urinary bladder 0.743260217350601 0.87957173675529 0.523700826061864 0.352941176470588 30.4 30 4 abnormal heart rate 0.743260217350601 0.87957173675529 0.523700826061864 0.352941176470588 30.4 30 4 enhanced behavioral response to xenobiotic 0.757557297543546 0.896277658805979 0.519336652511349 0.35 30.4 30 4 abnormal kidney cortex morphology 0.782593650715507 0.898829757278756 0.513629656329905 0.346153846153846 30.4 30 4 increased circulating estradiol level 0.838720653639373 0.955492386502377 0.463693439742276 0.3125 30.4 30 4 decreased airway responsiveness 0.931145382898643 1 0.404677911047804 0.272727272727273 30.4 30 4 decreased transitional stage T2 B cell number 4.54294436832895e-06 0.000124868222278655 2.42079257840073 1 4.1 4 1 increased neuronal precursor cell number 1.55504600577186e-05 0.000375551159160923 2.42079257840073 1 4.1 4 1 decreased transitional stage T1 B cell number 1.55504600577186e-05 0.000375551159160923 2.42079257840073 1 4.1 4 1 elevated level of mitotic sister chromatid exchange 5.32252904750817e-05 0.00108079926576952 2.42079257840073 1 4.1 4 1 liver cirrhosis 0.00062341116625104 0.00835975890053618 2.42079257840073 1 4.1 4 1 decreased macrophage nitric oxide production 0.00062341116625104 0.00835975890053618 2.42079257840073 1 4.1 4 1 abnormal pineal gland morphology 0.00213332156457516 0.0230222880341897 2.42079257840073 1 4.1 4 1 decreased DN3 thymocyte number 0.00213332156457516 0.0230222880341897 2.42079257840073 1 4.1 4 1 decreased DN2 thymocyte number 0.000182163690922639 0.00315771554822344 2.42079257840073 1 4.1 4 1 decreased brain cholesterol level 0.000182163690922639 0.00315771554822344 2.42079257840073 1 4.1 4 1 ductus venosus stenosis 0.000182163690922639 0.00315771554822344 2.42079257840073 1 4.1 4 1 abnormal B cell proliferation 1.16610067316966e-05 0.000287195586585102 2.219059863534 0.916666666666667 4.1 4 1 decreased B cell proliferation 7.90873247505134e-31 3.93459440633804e-28 2.206291970188 0.911392405063291 4.1 4 1 abnormal thymus physiology 0.000354623933813986 0.00546208690626805 2.15181562524509 0.888888888888889 4.1 4 1 increased fibroblast apoptosis 1.03337436551135e-11 7.5603492182632e-10 2.11819350610064 0.875 4.1 4 1 increased sensitivity to skin irradiation 0.00108473249405553 0.0130984081503065 2.11819350610064 0.875 4.1 4 1 colon polyps 0.00108473249405553 0.0130984081503065 2.11819350610064 0.875 4.1 4 1 pleural effusion 0.00108473249405553 0.0130984081503065 2.11819350610064 0.875 4.1 4 1 embryo cyst 0.00108473249405553 0.0130984081503065 2.11819350610064 0.875 4.1 4 1 increased brain apoptosis 0.00108473249405553 0.0130984081503065 2.11819350610064 0.875 4.1 4 1 abnormal spleen periarteriolar lymphoid sheath morphology 1.88334275170367e-05 0.000436872460157153 2.07496506720062 0.857142857142857 4.1 4 1 increased B-1 B cell number 1.88334275170367e-05 0.000436872460157153 2.07496506720062 0.857142857142857 4.1 4 1 decreased response to antigen 1.88334275170367e-05 0.000436872460157153 2.07496506720062 0.857142857142857 4.1 4 1 cellular necrosis 0.00327089601822145 0.0325454153813034 2.07496506720062 0.857142857142857 4.1 4 1 abnormal circulating alanine transaminase level 0.00327089601822145 0.0325454153813034 2.07496506720062 0.857142857142857 4.1 4 1 decreased activated T cell number 0.00327089601822145 0.0325454153813034 2.07496506720062 0.857142857142857 4.1 4 1 decreased mortality induced by ionizing radiation 0.00327089601822145 0.0325454153813034 2.07496506720062 0.857142857142857 4.1 4 1 heart hemorrhage 0.00327089601822145 0.0325454153813034 2.07496506720062 0.857142857142857 4.1 4 1 abnormal sperm annulus morphology 0.00327089601822145 0.0325454153813034 2.07496506720062 0.857142857142857 4.1 4 1 decreased T-helper 17 cell number 0.00327089601822145 0.0325454153813034 2.07496506720062 0.857142857142857 4.1 4 1 abnormal B cell differentiation 7.14887461747685e-27 2.73581932476518e-24 2.0217608347083 0.835164835164835 4.1 4 1 abnormal Peyer's patch follicle morphology 3.02332383956703e-06 8.49776050951749e-05 2.01732714866727 0.833333333333333 4.1 4 1 increased effector memory CD8-positive, alpha-beta T cell number 3.02332383956703e-06 8.49776050951749e-05 2.01732714866727 0.833333333333333 4.1 4 1 altered tumor susceptibility 0.000161903859980528 0.00290784008448783 2.01732714866727 0.833333333333333 4.1 4 1 abnormal vascular endothelial cell development 0.000161903859980528 0.00290784008448783 2.01732714866727 0.833333333333333 4.1 4 1 increased osteosarcoma incidence 0.000161903859980528 0.00290784008448783 2.01732714866727 0.833333333333333 4.1 4 1 abnormal lymph node cortex morphology 0.00968287355619577 0.0728779061150892 2.01732714866727 0.833333333333333 4.1 4 1 decreased posterior semicircular canal size 0.00968287355619577 0.0728779061150892 2.01732714866727 0.833333333333333 4.1 4 1 decreased liver function 0.00968287355619577 0.0728779061150892 2.01732714866727 0.833333333333333 4.1 4 1 abnormal immature B cell morphology 0.00968287355619577 0.0728779061150892 2.01732714866727 0.833333333333333 4.1 4 1 impaired granulocyte bactericidal activity 0.00968287355619577 0.0728779061150892 2.01732714866727 0.833333333333333 4.1 4 1 absent brachial lymph nodes 0.00968287355619577 0.0728779061150892 2.01732714866727 0.833333333333333 4.1 4 1 delayed chorioallantoic fusion 0.00968287355619577 0.0728779061150892 2.01732714866727 0.833333333333333 4.1 4 1 increased transitional stage T1 B cell number 0.00968287355619577 0.0728779061150892 2.01732714866727 0.833333333333333 4.1 4 1 absent third pharyngeal arch 0.00968287355619577 0.0728779061150892 2.01732714866727 0.833333333333333 4.1 4 1 abnormal vertebral artery origin 0.00968287355619577 0.0728779061150892 2.01732714866727 0.833333333333333 4.1 4 1 increased cellular sensitivity to gamma-irradiation 3.04034675270955e-14 3.60136311779286e-12 2.00874277782188 0.829787234042553 4.1 4 1 increased mortality induced by gamma-irradiation 3.42197294390505e-09 1.81109738254549e-07 2.00341454764198 0.827586206896552 4.1 4 1 abnormal lymphocyte physiology 8.67099900189227e-14 9.61788450225508e-12 1.99978517346147 0.826086956521739 4.1 4 1 decreased B-1 B cell number 1.17534943623322e-11 8.35337635037179e-10 1.98629134638008 0.82051282051282 4.1 4 1 abnormal thrombopoiesis 0.000465242886712984 0.00671347963475868 1.98064847323696 0.818181818181818 4.1 4 1 increased thymocyte apoptosis 7.71015632560442e-08 3.02031714329779e-06 1.95525554409289 0.807692307692308 4.1 4 1 abnormal gas homeostasis 0.00131464726402103 0.0151748727111476 1.93663406272058 0.8 4.1 4 1 absent inguinal lymph nodes 0.00131464726402103 0.0151748727111476 1.93663406272058 0.8 4.1 4 1 acanthocytosis 0.00131464726402103 0.0151748727111476 1.93663406272058 0.8 4.1 4 1 decreased macrophage cytokine production 0.00131464726402103 0.0151748727111476 1.93663406272058 0.8 4.1 4 1 lethality during fetal growth through weaning, complete penetrance 0.00131464726402103 0.0151748727111476 1.93663406272058 0.8 4.1 4 1 increased B cell derived lymphoma incidence 1.48212623129902e-13 1.56884638313034e-11 1.93663406272058 0.8 4.1 4 1 increased pre-B cell number 2.14301595544552e-07 7.72572781039235e-06 1.93663406272058 0.8 4.1 4 1 increased hemangiosarcoma incidence 5.9021138698105e-07 1.97067224847699e-05 1.91646079123391 0.791666666666667 4.1 4 1 abnormal cell cycle 1.90884123302059e-28 7.91373761189787e-26 1.91558369247362 0.791304347826087 4.1 4 1 spleen hyperplasia 1.05678554310069e-18 1.81293381962963e-16 1.9043568283419 0.786666666666667 4.1 4 1 lysosomal protein accumulation 0.000190190148721842 0.00328540274267765 1.90205131160057 0.785714285714286 4.1 4 1 abnormal hematopoietic stem cell physiology 1.6093526161635e-06 4.94230201568729e-05 1.89453332222666 0.782608695652174 4.1 4 1 abnormal thymus cortex morphology 2.84408879064848e-05 0.000619341450938007 1.88283867208945 0.777777777777778 4.1 4 1 increased effector memory CD4-positive, alpha-beta T cell number 2.84408879064848e-05 0.000619341450938007 1.88283867208945 0.777777777777778 4.1 4 1 abnormal hypoglossal nerve topology 2.84408879064848e-05 0.000619341450938007 1.88283867208945 0.777777777777778 4.1 4 1 heart hyperplasia 0.00364011245490096 0.0341046317573112 1.88283867208945 0.777777777777778 4.1 4 1 increased pheochromocytoma incidence 0.00364011245490096 0.0341046317573112 1.88283867208945 0.777777777777778 4.1 4 1 abnormal gut-associated lymphoid tissue morphology 0.00364011245490096 0.0341046317573112 1.88283867208945 0.777777777777778 4.1 4 1 decreased cellular sensitivity to ionizing radiation 0.00364011245490096 0.0341046317573112 1.88283867208945 0.777777777777778 4.1 4 1 absent cervical lymph nodes 0.00364011245490096 0.0341046317573112 1.88283867208945 0.777777777777778 4.1 4 1 abnormal telomere morphology 0.00364011245490096 0.0341046317573112 1.88283867208945 0.777777777777778 4.1 4 1 abnormal ventricle myocardium morphology 0.00364011245490096 0.0341046317573112 1.88283867208945 0.777777777777778 4.1 4 1 abnormal ductus venosus valve topology 0.00364011245490096 0.0341046317573112 1.88283867208945 0.777777777777778 4.1 4 1 decreased platelet dense granule number 0.00364011245490096 0.0341046317573112 1.88283867208945 0.777777777777778 4.1 4 1 inner cell mass degeneration 3.93703738361336e-08 1.6598949985997e-06 1.87416199618121 0.774193548387097 4.1 4 1 decreased IgM level 1.45430352665343e-22 4.25597649711813e-20 1.87174683896963 0.77319587628866 4.1 4 1 abnormal tail bud morphology 0.000516407643522067 0.00717828370198663 1.86214813723133 0.769230769230769 4.1 4 1 absent hypoglossal nerve 0.000516407643522067 0.00717828370198663 1.86214813723133 0.769230769230769 4.1 4 1 increased mammary adenocarcinoma incidence 3.04185341870949e-05 0.000652293998193092 1.81559443380054 0.75 4.1 4 1 abnormal thymocyte activation 3.04185341870949e-05 0.000652293998193092 1.81559443380054 0.75 4.1 4 1 increased intestinal adenocarcinoma incidence 0.000201774878046426 0.00340281362129143 1.81559443380054 0.75 4.1 4 1 abnormal level of surface class II molecules 0.000201774878046426 0.00340281362129143 1.81559443380054 0.75 4.1 4 1 decreased liver cholesterol level 0.000201774878046426 0.00340281362129143 1.81559443380054 0.75 4.1 4 1 interstitial pneumonia 0.00137525996691035 0.0156208181173036 1.81559443380054 0.75 4.1 4 1 increased cardiac output 0.00982938659071917 0.0730315209839536 1.81559443380054 0.75 4.1 4 1 abnormal extraembryonic tissue physiology 0.00982938659071917 0.0730315209839536 1.81559443380054 0.75 4.1 4 1 abnormal NK cell morphology 0.00982938659071917 0.0730315209839536 1.81559443380054 0.75 4.1 4 1 craniofacial phenotype 0.00982938659071917 0.0730315209839536 1.81559443380054 0.75 4.1 4 1 abnormal mitotic spindle assembly checkpoint 0.00982938659071917 0.0730315209839536 1.81559443380054 0.75 4.1 4 1 myocardial trabeculae hypoplasia 0.00982938659071917 0.0730315209839536 1.81559443380054 0.75 4.1 4 1 abnormal macrophage activation involved in immune response 0.00982938659071917 0.0730315209839536 1.81559443380054 0.75 4.1 4 1 decreased vascular endothelial cell proliferation 0.00982938659071917 0.0730315209839536 1.81559443380054 0.75 4.1 4 1 subcutaneous edema 7.24750877896142e-07 2.3721286957456e-05 1.81559443380054 0.75 4.1 4 1 increased B cell proliferation 7.73553673479999e-13 6.87219558136249e-11 1.80533683812936 0.745762711864407 4.1 4 1 abnormal erythropoiesis 1.67248243906623e-21 4.37926322860762e-19 1.79830305824054 0.742857142857143 4.1 4 1 abnormal humoral immune response 1.67248243906623e-21 4.37926322860762e-19 1.79830305824054 0.742857142857143 4.1 4 1 abnormal lymph node B cell domain morphology 0.000523762207803246 0.00717828370198663 1.7752478908272 0.733333333333333 4.1 4 1 abnormal placenta size 0.000523762207803246 0.00717828370198663 1.7752478908272 0.733333333333333 4.1 4 1 abnormal trophectoderm morphology 0.000523762207803246 0.00717828370198663 1.7752478908272 0.733333333333333 4.1 4 1 abnormal dendritic cell morphology 0.000523762207803246 0.00717828370198663 1.7752478908272 0.733333333333333 4.1 4 1 intestinal inflammation 3.08377889124617e-05 0.000658446351242475 1.76057642065507 0.727272727272727 4.1 4 1 abnormal sphenoid bone morphology 0.00357972560350916 0.0341046317573112 1.76057642065507 0.727272727272727 4.1 4 1 abnormal proximal-distal axis patterning 0.00357972560350916 0.0341046317573112 1.76057642065507 0.727272727272727 4.1 4 1 abnormal dorsal-ventral polarity of the somites 0.00357972560350916 0.0341046317573112 1.76057642065507 0.727272727272727 4.1 4 1 thin hypoglossal nerve 0.00357972560350916 0.0341046317573112 1.76057642065507 0.727272727272727 4.1 4 1 reduced sympathetic cervical ganglion size 0.00357972560350916 0.0341046317573112 1.76057642065507 0.727272727272727 4.1 4 1 abnormal CD8-positive, alpha-beta T cell physiology 1.89956846377086e-06 5.76241043125612e-05 1.75298772918673 0.724137931034483 4.1 4 1 abnormal megakaryocyte differentiation 0.000200924108103883 0.00340281362129143 1.74835019551164 0.722222222222222 4.1 4 1 increased autoantibody level 4.79646203808781e-08 1.95593431471204e-06 1.73800492808257 0.717948717948718 4.1 4 1 increased T cell derived lymphoma incidence 1.24263696373829e-09 7.18851034255578e-08 1.72913755600052 0.714285714285714 4.1 4 1 premature aging 4.74835569660988e-06 0.000129797085662825 1.72913755600052 0.714285714285714 4.1 4 1 increased hemangioma incidence 0.00133195138052263 0.0152332370531037 1.72913755600052 0.714285714285714 4.1 4 1 vascular smooth muscle hypoplasia 0.00133195138052263 0.0152332370531037 1.72913755600052 0.714285714285714 4.1 4 1 testis degeneration 0.00133195138052263 0.0152332370531037 1.72913755600052 0.714285714285714 4.1 4 1 mammary gland hyperplasia 0.0257128174011316 0.158318399221077 1.72913755600052 0.714285714285714 4.1 4 1 skin photosensitivity 0.0257128174011316 0.158318399221077 1.72913755600052 0.714285714285714 4.1 4 1 abnormal hypersensitivity reaction 0.0257128174011316 0.158318399221077 1.72913755600052 0.714285714285714 4.1 4 1 abnormal gastrulation movements 0.0257128174011316 0.158318399221077 1.72913755600052 0.714285714285714 4.1 4 1 aorta coarctation 0.0257128174011316 0.158318399221077 1.72913755600052 0.714285714285714 4.1 4 1 increased cell nucleus count 0.0257128174011316 0.158318399221077 1.72913755600052 0.714285714285714 4.1 4 1 abnormal MHC II cell surface expression on macrophages 0.0257128174011316 0.158318399221077 1.72913755600052 0.714285714285714 4.1 4 1 absent popliteal lymph nodes 0.0257128174011316 0.158318399221077 1.72913755600052 0.714285714285714 4.1 4 1 abnormal uterus physiology 0.0257128174011316 0.158318399221077 1.72913755600052 0.714285714285714 4.1 4 1 increased tumor latency 0.0257128174011316 0.158318399221077 1.72913755600052 0.714285714285714 4.1 4 1 decreased DN4 thymocyte number 0.0257128174011316 0.158318399221077 1.72913755600052 0.714285714285714 4.1 4 1 arteritis 0.0257128174011316 0.158318399221077 1.72913755600052 0.714285714285714 4.1 4 1 abnormal aortic valve cusp morphology 0.0257128174011316 0.158318399221077 1.72913755600052 0.714285714285714 4.1 4 1 embryonic lethality at implantation, incomplete penetrance 0.0257128174011316 0.158318399221077 1.72913755600052 0.714285714285714 4.1 4 1 small tail bud 0.0257128174011316 0.158318399221077 1.72913755600052 0.714285714285714 4.1 4 1 absent connection between subcutaneous lymph vessels and lymph sac 0.0257128174011316 0.158318399221077 1.72913755600052 0.714285714285714 4.1 4 1 decreased B cell number 6.86283705839886e-36 5.69043572758905e-33 1.7274587816743 0.713592233009709 4.1 4 1 arrested B cell differentiation 4.71829137348562e-08 1.94139337731123e-06 1.71226792130783 0.707317073170732 4.1 4 1 abnormal ectoplacental cone morphology 0.000502787640917353 0.00716724502453819 1.70879476122404 0.705882352941177 4.1 4 1 abnormal myelopoiesis 1.87630212093237e-08 8.48600277421684e-07 1.7055584075096 0.704545454545455 4.1 4 1 increased T cell proliferation 2.70669935053791e-18 4.34381589320196e-16 1.69681722785098 0.700934579439252 4.1 4 1 spleen atrophy 0.000191768515315771 0.00328982194377917 1.69455480488051 0.7 4.1 4 1 increased skin tumor incidence 0.000191768515315771 0.00328982194377917 1.69455480488051 0.7 4.1 4 1 abnormal immune cell physiology 0.00906619790028745 0.0698209513218732 1.69455480488051 0.7 4.1 4 1 bifid ureter 0.00906619790028745 0.0698209513218732 1.69455480488051 0.7 4.1 4 1 absent CD4-positive, alpha beta T cells 0.00906619790028745 0.0698209513218732 1.69455480488051 0.7 4.1 4 1 absent axillary lymph nodes 0.00906619790028745 0.0698209513218732 1.69455480488051 0.7 4.1 4 1 increased circulating fructosamine level 0.00906619790028745 0.0698209513218732 1.69455480488051 0.7 4.1 4 1 abnormal left subclavian artery morphology 0.00906619790028745 0.0698209513218732 1.69455480488051 0.7 4.1 4 1 decreased trabecular bone connectivity density 0.00906619790028745 0.0698209513218732 1.69455480488051 0.7 4.1 4 1 decreased double-positive T cell number 4.03125243958985e-17 5.57096691304431e-15 1.69455480488051 0.7 4.1 4 1 myeloid hyperplasia 1.79549438225507e-06 5.4801132219135e-05 1.68721906979445 0.696969696969697 4.1 4 1 abnormal cell death 1.80736255443799e-08 8.32558213734166e-07 1.68402961975703 0.695652173913043 4.1 4 1 failure to gastrulate 1.80736255443799e-08 8.32558213734166e-07 1.68402961975703 0.695652173913043 4.1 4 1 abnormal leukocyte migration 2.85041025584177e-09 1.55832868382558e-07 1.6759333235082 0.692307692307692 4.1 4 1 increased leukemia incidence 2.85083803547344e-05 0.000619341450938007 1.6759333235082 0.692307692307692 4.1 4 1 increased foot pad pigmentation 0.00330767769453398 0.0325855376837753 1.6759333235082 0.692307692307692 4.1 4 1 increased pituitary adenoma incidence 0.00330767769453398 0.0325855376837753 1.6759333235082 0.692307692307692 4.1 4 1 lymphoid hypoplasia 0.00330767769453398 0.0325855376837753 1.6759333235082 0.692307692307692 4.1 4 1 abnormal coping response 0.00330767769453398 0.0325855376837753 1.6759333235082 0.692307692307692 4.1 4 1 small pituitary gland 0.00330767769453398 0.0325855376837753 1.6759333235082 0.692307692307692 4.1 4 1 increased embryonic tissue cell apoptosis 3.20994046997989e-13 3.13126545846077e-11 1.67593332350819 0.692307692307692 4.1 4 1 decreased T cell proliferation 1.89174565484838e-23 6.27428975524714e-21 1.6683840743032 0.689189189189189 4.1 4 1 extramedullary hematopoiesis 3.60377411051821e-17 5.12250748566517e-15 1.66714960587975 0.688679245283019 4.1 4 1 intraventricular hemorrhage 0.00123213433326825 0.0144572365754942 1.6642948976505 0.6875 4.1 4 1 blepharitis 0.00123213433326825 0.0144572365754942 1.6642948976505 0.6875 4.1 4 1 increased lung adenocarcinoma incidence 6.80332294608269e-09 3.38465316567614e-07 1.66132824007893 0.686274509803922 4.1 4 1 increased malignant tumor incidence 0.000465475363856619 0.00671347963475868 1.65633176416892 0.684210526315789 4.1 4 1 increased liver adenoma incidence 0.000465475363856619 0.00671347963475868 1.65633176416892 0.684210526315789 4.1 4 1 abnormal cell differentiation 2.61364134094617e-07 9.28776119371942e-06 1.65322419988342 0.682926829268293 4.1 4 1 abnormal lysosome physiology 0.000177638663314073 0.00311180404925181 1.65054039436413 0.681818181818182 4.1 4 1 abnormal mesenteric lymph node morphology 0.000177638663314073 0.00311180404925181 1.65054039436413 0.681818181818182 4.1 4 1 increased mammary gland tumor incidence 0.000177638663314073 0.00311180404925181 1.65054039436413 0.681818181818182 4.1 4 1 embryonic lethality before implantation, incomplete penetrance 0.000177638663314073 0.00311180404925181 1.65054039436413 0.681818181818182 4.1 4 1 abnormal cell nucleus morphology 4.07021500537679e-08 1.70162350014702e-06 1.64819920231539 0.680851063829787 4.1 4 1 embryonic lethality before implantation, complete penetrance 3.35203400433043e-19 6.41398814290149e-17 1.64613895331249 0.68 4.1 4 1 abnormal preimplantation embryo development 6.83127539667386e-05 0.00134863472612907 1.64613895331249 0.68 4.1 4 1 lymphoid hyperplasia 2.64278177752141e-05 0.000585820859635213 1.64268067820049 0.678571428571429 4.1 4 1 abnormal CD8-positive, alpha beta T cell morphology 1.02730748363106e-05 0.000255934563016881 1.63989174665856 0.67741935483871 4.1 4 1 abnormal T cell proliferation 1.02730748363106e-05 0.000255934563016881 1.63989174665856 0.67741935483871 4.1 4 1 pale yolk sac 6.36855761845137e-13 5.8575828117621e-11 1.63330583602941 0.674698795180723 4.1 4 1 embryonic lethality between implantation and somite formation, complete penetrance 2.13610014503579e-34 1.51815688879329e-31 1.62044890962334 0.669387755102041 4.1 4 1 embryonic lethality at implantation, complete penetrance 0.000420211229866818 0.00627793053629856 1.61386171893382 0.666666666666667 4.1 4 1 abnormal definitive hematopoiesis 8.69959402214027e-14 9.61788450225508e-12 1.61386171893382 0.666666666666667 4.1 4 1 abnormal apoptosis 1.37346498758281e-08 6.50760791735663e-07 1.61386171893382 0.666666666666667 4.1 4 1 abnormal lysosome morphology 3.66505119870491e-06 0.000101297942853094 1.61386171893382 0.666666666666667 4.1 4 1 abnormal spleen marginal zone morphology 2.40772446967392e-05 0.000543361827479524 1.61386171893382 0.666666666666667 4.1 4 1 decreased circulating fructosamine level 6.20916326204529e-05 0.00124058583247692 1.61386171893382 0.666666666666667 4.1 4 1 abnormal thymus medulla morphology 0.00110651470654429 0.0131382116111166 1.61386171893382 0.666666666666667 4.1 4 1 decreased cellular sensitivity to gamma-irradiation 0.00110651470654429 0.0131382116111166 1.61386171893382 0.666666666666667 4.1 4 1 absent inner cell mass 0.00110651470654429 0.0131382116111166 1.61386171893382 0.666666666666667 4.1 4 1 increased gastrointestinal tumor incidence 0.00110651470654429 0.0131382116111166 1.61386171893382 0.666666666666667 4.1 4 1 absent egg cylinders 0.0029483297259614 0.0304314115905767 1.61386171893382 0.666666666666667 4.1 4 1 decreased thymocyte apoptosis 0.0029483297259614 0.0304314115905767 1.61386171893382 0.666666666666667 4.1 4 1 myocarditis 0.00798865687670679 0.063589708738586 1.61386171893382 0.666666666666667 4.1 4 1 loss of dopaminergic neurons 0.00798865687670679 0.063589708738586 1.61386171893382 0.666666666666667 4.1 4 1 small intestinal inflammation 0.00798865687670679 0.063589708738586 1.61386171893382 0.666666666666667 4.1 4 1 pale placenta 0.00798865687670679 0.063589708738586 1.61386171893382 0.666666666666667 4.1 4 1 abnormal fatty acid level 0.00798865687670679 0.063589708738586 1.61386171893382 0.666666666666667 4.1 4 1 increased fibrosarcoma incidence 0.00798865687670679 0.063589708738586 1.61386171893382 0.666666666666667 4.1 4 1 embryonic lethality between implantation and placentation, incomplete penetrance 0.00798865687670679 0.063589708738586 1.61386171893382 0.666666666666667 4.1 4 1 abnormal vitelline vein connection 0.00798865687670679 0.063589708738586 1.61386171893382 0.666666666666667 4.1 4 1 distorted hair follicle pattern 0.0222079348623556 0.146725731660318 1.61386171893382 0.666666666666667 4.1 4 1 crypts of Lieberkuhn abscesses 0.0222079348623556 0.146725731660318 1.61386171893382 0.666666666666667 4.1 4 1 decreased level of surface class I molecules 0.0222079348623556 0.146725731660318 1.61386171893382 0.666666666666667 4.1 4 1 abnormal germ cell morphology 0.0222079348623556 0.146725731660318 1.61386171893382 0.666666666666667 4.1 4 1 decreased fear-related response 0.0222079348623556 0.146725731660318 1.61386171893382 0.666666666666667 4.1 4 1 decreased vestibular hair cell number 0.0222079348623556 0.146725731660318 1.61386171893382 0.666666666666667 4.1 4 1 abnormal leukopoiesis 0.0222079348623556 0.146725731660318 1.61386171893382 0.666666666666667 4.1 4 1 shortened ST segment 0.0222079348623556 0.146725731660318 1.61386171893382 0.666666666666667 4.1 4 1 decreased effector memory CD4-positive, alpha-beta T cell number 0.0222079348623556 0.146725731660318 1.61386171893382 0.666666666666667 4.1 4 1 increased myeloid cell number 0.0222079348623556 0.146725731660318 1.61386171893382 0.666666666666667 4.1 4 1 increased endoplasmic reticulum stress 0.0222079348623556 0.146725731660318 1.61386171893382 0.666666666666667 4.1 4 1 increased hepatocyte apoptosis 1.43680668898016e-06 4.46757079854769e-05 1.61386171893382 0.666666666666667 4.1 4 1 pale liver 4.94700646064814e-11 3.28151428556327e-09 1.60295724785994 0.662162162162162 4.1 4 1 increased tumor incidence 1.92329773396608e-17 2.99012694577539e-15 1.60084670507145 0.661290322580645 4.1 4 1 increased bone marrow cell number 3.31073207047125e-06 9.2533101407834e-05 1.59262669631627 0.657894736842105 4.1 4 1 decreased IgG level 1.70430828243322e-15 2.11973342627632e-13 1.59205277678606 0.657657657657658 4.1 4 1 increased carcinoma incidence 8.44976397872249e-06 0.00021781127354479 1.59080655152048 0.657142857142857 4.1 4 1 enlarged spleen 1.33658587464934e-37 1.32990294527609e-34 1.58864512957548 0.65625 4.1 4 1 abnormal embryo turning 2.85433982373148e-08 1.22416729509173e-06 1.58451877858957 0.654545454545455 4.1 4 1 liver hypoplasia 7.20117729393971e-08 2.88918201914113e-06 1.58282591664663 0.653846153846154 4.1 4 1 embryonic lethality between implantation and placentation, complete penetrance 4.60202065003414e-07 1.54696302256215e-05 1.57877776852221 0.652173913043478 4.1 4 1 abnormal B cell morphology 0.000372495584677785 0.00566717288615285 1.57877776852221 0.652173913043478 4.1 4 1 abnormal Peyer's patch T cell area morphology 0.000973788082575337 0.0121497045709388 1.57351517596047 0.65 4.1 4 1 abnormal chromosome morphology 7.53353683654764e-06 0.000196226941161385 1.57024383463831 0.648648648648649 4.1 4 1 decreased embryo size 3.6766362878558e-59 9.14563276604131e-56 1.56997008222641 0.648535564853556 4.1 4 1 increased T cell number 5.27055513029457e-12 4.09703308956492e-10 1.56801337464593 0.647727272727273 4.1 4 1 impaired hematopoiesis 1.6257744562216e-07 5.99127994052033e-06 1.56639519778871 0.647058823529412 4.1 4 1 abnormal spleen red pulp morphology 1.92183484651049e-05 0.000442644831545819 1.5663951977887 0.647058823529412 4.1 4 1 hyperlipidemia 0.00256926993591156 0.0269097219603369 1.5663951977887 0.647058823529412 4.1 4 1 abnormal embryonic-extraembryonic boundary morphology 0.00256926993591156 0.0269097219603369 1.5663951977887 0.647058823529412 4.1 4 1 increased brain size 0.00256926993591156 0.0269097219603369 1.5663951977887 0.647058823529412 4.1 4 1 decreased bone marrow cell number 5.14770059645432e-10 3.04878696040003e-08 1.55859248198403 0.643835616438356 4.1 4 1 abnormal spleen white pulp morphology 2.62523367433939e-06 7.54944365886617e-05 1.55622380040047 0.642857142857143 4.1 4 1 failure of zygotic cell division 0.00686398505975445 0.0586740990932618 1.55622380040047 0.642857142857143 4.1 4 1 absent olfactory bulb 0.00686398505975445 0.0586740990932618 1.55622380040047 0.642857142857143 4.1 4 1 abnormal maternal decidual layer morphology 0.00686398505975445 0.0586740990932618 1.55622380040047 0.642857142857143 4.1 4 1 increased stomach tumor incidence 0.00686398505975445 0.0586740990932618 1.55622380040047 0.642857142857143 4.1 4 1 multiple persisting craniopharyngeal ducts 0.00686398505975445 0.0586740990932618 1.55622380040047 0.642857142857143 4.1 4 1 abnormal vitelline vein topology 0.00686398505975445 0.0586740990932618 1.55622380040047 0.642857142857143 4.1 4 1 embryonic lethality, complete penetrance 1.22497390658257e-38 1.52356129631208e-35 1.55568175100987 0.642633228840125 4.1 4 1 preweaning lethality, complete penetrance 4.0846782893821e-88 2.03212744896759e-84 1.55388712802749 0.641891891891892 4.1 4 1 increased monocyte cell number 6.02616503739081e-13 5.65663604924892e-11 1.54930725017646 0.64 4.1 4 1 increased cellular sensitivity to ionizing radiation 0.000325734381840988 0.00506415171768412 1.54930725017646 0.64 4.1 4 1 decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 0.000325734381840988 0.00506415171768412 1.54930725017646 0.64 4.1 4 1 decreased T cell number 6.37603069655646e-20 1.37916316153776e-17 1.54870581102655 0.639751552795031 4.1 4 1 increased double-negative T cell number 2.02483930510457e-08 9.07529328188759e-07 1.54771984520702 0.639344262295082 4.1 4 1 increased activated T cell number 0.000844713221334125 0.0108310522580857 1.54050436807319 0.636363636363636 4.1 4 1 impaired humoral immune response 0.000844713221334125 0.0108310522580857 1.54050436807319 0.636363636363636 4.1 4 1 delayed hepatic development 0.0186675244196495 0.12704642132388 1.54050436807319 0.636363636363636 4.1 4 1 loss of cortex neurons 0.0186675244196495 0.12704642132388 1.54050436807319 0.636363636363636 4.1 4 1 decreased circulating total protein level 1.27398761844096e-07 4.76548000131111e-06 1.54050436807319 0.636363636363636 4.1 4 1 abnormal T cell subpopulation ratio 4.30807563939086e-05 0.000889322668297491 1.54050436807319 0.636363636363636 4.1 4 1 abnormal cytokine secretion 8.66231931165937e-19 1.53910852055376e-16 1.54050436807319 0.636363636363636 4.1 4 1 increased granulocyte number 1.01031019131884e-09 5.91328611977792e-08 1.53753042141668 0.635135135135135 4.1 4 1 decreased IgA level 3.19875719229062e-07 1.12069134025675e-05 1.53627221321585 0.634615384615385 4.1 4 1 abnormal CD4-positive, alpha-beta T cell physiology 2.52030807345428e-09 1.4088238949927e-07 1.5343051553244 0.633802816901408 4.1 4 1 abnormal T cell differentiation 1.17520617997723e-12 9.58467335309296e-11 1.53396757443214 0.633663366336634 4.1 4 1 abnormal microglial cell physiology 0.000110022712697504 0.00207334468056849 1.53316863298713 0.633333333333333 4.1 4 1 small superior vagus ganglion 0.00220543929400887 0.0236977548330327 1.52892162846362 0.631578947368421 4.1 4 1 embryonic lethality between implantation and somite formation, incomplete penetrance 0.00220543929400887 0.0236977548330327 1.52892162846362 0.631578947368421 4.1 4 1 abnormal immune system morphology 2.02122487969033e-06 6.04212248645592e-05 1.52615184290481 0.630434782608696 4.1 4 1 increased brain weight 0.000281890965676643 0.00448053531706486 1.52420273454861 0.62962962962963 4.1 4 1 embryonic growth arrest 3.89606454746771e-26 1.38449436597513e-23 1.5222451148022 0.62882096069869 4.1 4 1 embryonic lethality between somite formation and embryo turning, complete penetrance 5.51282624910566e-09 2.79860312135721e-07 1.52164104928046 0.628571428571429 4.1 4 1 abnormal embryo size 1.30305533681551e-13 1.40928267405591e-11 1.52102896518984 0.628318584070796 4.1 4 1 abnormal vasculogenesis 5.08741295874762e-06 0.000137553692770486 1.52003254922836 0.627906976744186 4.1 4 1 abnormal double-strand DNA break repair 5.08741295874762e-06 0.000137553692770486 1.52003254922836 0.627906976744186 4.1 4 1 abnormal neural tube closure 2.74846304219855e-10 1.66751263840704e-08 1.51664113345588 0.626506024096386 4.1 4 1 decreased lymphocyte cell number 5.80657954546402e-15 7.04578859480085e-13 1.51299536150045 0.625 4.1 4 1 small lymph nodes 0.000725013992471647 0.00949195950670116 1.51299536150045 0.625 4.1 4 1 abnormal inner cell mass apoptosis 0.000725013992471647 0.00949195950670116 1.51299536150045 0.625 4.1 4 1 decreased mast cell number 0.00580865538044999 0.0510566440242733 1.51299536150045 0.625 4.1 4 1 abnormal meiosis 0.00580865538044999 0.0510566440242733 1.51299536150045 0.625 4.1 4 1 decreased fibroblast apoptosis 0.00580865538044999 0.0510566440242733 1.51299536150045 0.625 4.1 4 1 absent pre-B cells 0.0521852020851524 0.275314295200035 1.51299536150045 0.625 4.1 4 1 abnormal vagus ganglion morphology 0.0521852020851524 0.275314295200035 1.51299536150045 0.625 4.1 4 1 abnormal hepatobiliary system morphology 0.0521852020851524 0.275314295200035 1.51299536150045 0.625 4.1 4 1 abnormal neuron apoptosis 0.0521852020851524 0.275314295200035 1.51299536150045 0.625 4.1 4 1 abnormal eyelid aperture 0.0521852020851524 0.275314295200035 1.51299536150045 0.625 4.1 4 1 binucleate 0.0521852020851524 0.275314295200035 1.51299536150045 0.625 4.1 4 1 accumulation of giant lysosomes in kidney/renal tubule cells 0.0521852020851524 0.275314295200035 1.51299536150045 0.625 4.1 4 1 abnormal choroid pigmentation 0.0521852020851524 0.275314295200035 1.51299536150045 0.625 4.1 4 1 abnormal meiotic spindle morphology 0.0521852020851524 0.275314295200035 1.51299536150045 0.625 4.1 4 1 abnormal cerebellum deep nucleus morphology 0.0521852020851524 0.275314295200035 1.51299536150045 0.625 4.1 4 1 increased caudal vertebrae number 0.0521852020851524 0.275314295200035 1.51299536150045 0.625 4.1 4 1 abnormal maxillary prominence morphology 0.0521852020851524 0.275314295200035 1.51299536150045 0.625 4.1 4 1 absent ureteric bud 0.0521852020851524 0.275314295200035 1.51299536150045 0.625 4.1 4 1 increased aorta wall thickness 0.0521852020851524 0.275314295200035 1.51299536150045 0.625 4.1 4 1 lethality during fetal growth through weaning, incomplete penetrance 0.0521852020851524 0.275314295200035 1.51299536150045 0.625 4.1 4 1 decreased cranium length 0.0521852020851524 0.275314295200035 1.51299536150045 0.625 4.1 4 1 increased cardiac stroke volume 0.0521852020851524 0.275314295200035 1.51299536150045 0.625 4.1 4 1 absent hypoglossal canal 0.0521852020851524 0.275314295200035 1.51299536150045 0.625 4.1 4 1 increased mammary gland apoptosis 0.0521852020851524 0.275314295200035 1.51299536150045 0.625 4.1 4 1 thymus hypoplasia 7.29179419658748e-16 9.30171182769813e-14 1.508609867699 0.623188405797101 4.1 4 1 pallor 1.10581406908198e-19 2.29226041403451e-17 1.50780794883245 0.622857142857143 4.1 4 1 decreased cell proliferation 1.38931679669003e-20 3.14175048342404e-18 1.50481700819505 0.621621621621622 4.1 4 1 abnormal T cell activation 4.19187333609034e-09 2.19521787863678e-07 1.50481700819505 0.621621621621622 4.1 4 1 abnormal spleen morphology 2.37686530511339e-19 4.72996195717565e-17 1.50256091073149 0.620689655172414 4.1 4 1 increased spleen weight 5.29870225269022e-13 5.06943148214112e-11 1.49960602201815 0.619469026548673 4.1 4 1 abnormal hematopoietic system physiology 0.00187335046822668 0.020536007158511 1.49858588186712 0.619047619047619 4.1 4 1 liver degeneration 0.00187335046822668 0.020536007158511 1.49858588186712 0.619047619047619 4.1 4 1 abnormal erythrocyte physiology 0.00187335046822668 0.020536007158511 1.49858588186712 0.619047619047619 4.1 4 1 increased muscle cell glucose uptake 0.00187335046822668 0.020536007158511 1.49858588186712 0.619047619047619 4.1 4 1 pericardial edema 2.5740925608015e-08 1.1233430254375e-06 1.49519541607104 0.617647058823529 4.1 4 1 decreased mean corpuscular hemoglobin 2.5740925608015e-08 1.1233430254375e-06 1.49519541607104 0.617647058823529 4.1 4 1 abnormal oocyte morphology 8.16277230481296e-05 0.00158632000845486 1.49519541607104 0.617647058823529 4.1 4 1 decreased Peyer's patch number 0.00061731132396795 0.00832282882585516 1.48971850978506 0.615384615384615 4.1 4 1 abnormal mast cell morphology 0.0154782235681832 0.108151913274876 1.48971850978506 0.615384615384615 4.1 4 1 abnormal telomere length 0.0154782235681832 0.108151913274876 1.48971850978506 0.615384615384615 4.1 4 1 abnormal exocrine pancreas morphology 0.0154782235681832 0.108151913274876 1.48971850978506 0.615384615384615 4.1 4 1 orthokeratosis 0.0154782235681832 0.108151913274876 1.48971850978506 0.615384615384615 4.1 4 1 empty decidua capsularis 0.0154782235681832 0.108151913274876 1.48971850978506 0.615384615384615 4.1 4 1 small liver 3.14808170766966e-09 1.7023594017018e-07 1.48971850978506 0.615384615384615 4.1 4 1 abnormal cell morphology 9.804106483993e-13 8.2670219928585e-11 1.48645158322852 0.614035087719298 4.1 4 1 increased hepatocellular carcinoma incidence 4.54442396445782e-07 1.53799382470596e-05 1.48645158322852 0.614035087719298 4.1 4 1 autoimmune response 0.000206363760161117 0.00342219902267186 1.48371158031012 0.612903225806452 4.1 4 1 decreased thymus weight 0.000206363760161117 0.00342219902267186 1.48371158031012 0.612903225806452 4.1 4 1 decreased double-negative T cell number 0.000206363760161117 0.00342219902267186 1.48371158031012 0.612903225806452 4.1 4 1 abnormal trophoblast giant cell morphology 6.96989496169249e-05 0.00136516643442599 1.479373242356 0.611111111111111 4.1 4 1 small thoracic cage 0.00486788529634583 0.0436355483771541 1.479373242356 0.611111111111111 4.1 4 1 embryonic lethality during organogenesis, complete penetrance 6.68894253159679e-56 1.1092496364898e-52 1.47841261038044 0.610714285714286 4.1 4 1 failure of blastocyst to hatch from the zona pellucida 0.000522370595466733 0.00717828370198663 1.46976692260044 0.607142857142857 4.1 4 1 increased bone resorption 0.000522370595466733 0.00717828370198663 1.46976692260044 0.607142857142857 4.1 4 1 anemia 2.14313272970808e-21 5.33104266514885e-19 1.46853767789238 0.606635071090047 4.1 4 1 increased cardiomyocyte apoptosis 0.000175079871972186 0.00311180404925181 1.46714701721256 0.606060606060606 4.1 4 1 decreased erythrocyte cell number 3.66091618885083e-16 4.92244811879267e-14 1.46481079584757 0.605095541401274 4.1 4 1 abnormal embryonic neuroepithelium morphology 8.23646217997455e-07 2.64363866744344e-05 1.46082310765561 0.603448275862069 4.1 4 1 thrombocytosis 8.23646217997455e-07 2.64363866744344e-05 1.46082310765561 0.603448275862069 4.1 4 1 abnormal cell migration 1.71303936894769e-05 0.000407768940694487 1.45247554704044 0.6 4.1 4 1 liver inflammation 2.36030305885293e-12 1.86389011393545e-10 1.45247554704044 0.6 4.1 4 1 spleen hypoplasia 5.43293108082827e-11 3.55642527988429e-09 1.45247554704044 0.6 4.1 4 1 testicular atrophy 5.88024143709499e-06 0.000156439578339827 1.45247554704044 0.6 4.1 4 1 decreased oocyte number 5.88024143709499e-06 0.000156439578339827 1.45247554704044 0.6 4.1 4 1 abnormal liver development 0.000147906147380311 0.00268552220152208 1.45247554704044 0.6 4.1 4 1 increased metastatic potential 0.000439892746310165 0.00649396561689339 1.45247554704044 0.6 4.1 4 1 spontaneous skin ulceration 0.00132393340841764 0.0152332370531037 1.45247554704044 0.6 4.1 4 1 abnormal vascular regression 0.00405291611115919 0.0372015823856401 1.45247554704044 0.6 4.1 4 1 small gonad 0.00405291611115919 0.0372015823856401 1.45247554704044 0.6 4.1 4 1 abnormal circulating enzyme level 0.00405291611115919 0.0372015823856401 1.45247554704044 0.6 4.1 4 1 abnormal sperm mitochondrial sheath morphology 0.00405291611115919 0.0372015823856401 1.45247554704044 0.6 4.1 4 1 macrocytosis 0.012737468060444 0.0913096593670156 1.45247554704044 0.6 4.1 4 1 delayed intramembranous bone ossification 0.012737468060444 0.0913096593670156 1.45247554704044 0.6 4.1 4 1 immune system phenotype 0.012737468060444 0.0913096593670156 1.45247554704044 0.6 4.1 4 1 liver vascular congestion 0.012737468060444 0.0913096593670156 1.45247554704044 0.6 4.1 4 1 decreased brown adipose tissue mass 0.012737468060444 0.0913096593670156 1.45247554704044 0.6 4.1 4 1 enlarged testis 0.0419205403054578 0.232761928593362 1.45247554704044 0.6 4.1 4 1 absent trophoblast giant cells 0.0419205403054578 0.232761928593362 1.45247554704044 0.6 4.1 4 1 acrania 0.0419205403054578 0.232761928593362 1.45247554704044 0.6 4.1 4 1 abnormal plasma membrane morphology 0.0419205403054578 0.232761928593362 1.45247554704044 0.6 4.1 4 1 abnormal corneal endothelium morphology 0.0419205403054578 0.232761928593362 1.45247554704044 0.6 4.1 4 1 ascites 0.0419205403054578 0.232761928593362 1.45247554704044 0.6 4.1 4 1 tachypnea 0.0419205403054578 0.232761928593362 1.45247554704044 0.6 4.1 4 1 abnormal cerebellar granule cell migration 0.0419205403054578 0.232761928593362 1.45247554704044 0.6 4.1 4 1 aorta stenosis 0.0419205403054578 0.232761928593362 1.45247554704044 0.6 4.1 4 1 thin ventricle myocardium compact layer 0.0419205403054578 0.232761928593362 1.45247554704044 0.6 4.1 4 1 thick aortic valve cusps 0.0419205403054578 0.232761928593362 1.45247554704044 0.6 4.1 4 1 decreased macrophage apoptosis 0.0419205403054578 0.232761928593362 1.45247554704044 0.6 4.1 4 1 increased B cell number 5.72996819335773e-12 4.38562950183918e-10 1.44833744006881 0.598290598290598 4.1 4 1 abnormal dendritic cell physiology 4.63700672376778e-11 3.11744708793847e-09 1.4479507010995 0.598130841121495 4.1 4 1 abnormal inflammatory response 7.19631703168768e-08 2.88918201914113e-06 1.44575112321154 0.597222222222222 4.1 4 1 decreased circulating serum albumin level 3.20497413446059e-10 1.92105377336644e-08 1.44269456692569 0.595959595959596 4.1 4 1 abnormal somite development 2.13236574087005e-08 9.47189246502542e-07 1.44021836942828 0.594936708860759 4.1 4 1 skin inflammation 0.000124510453091888 0.00231134143332889 1.43939018175178 0.594594594594595 4.1 4 1 abnormal embryonic hematopoiesis 0.000369008659494929 0.00563134380670942 1.43734559342543 0.59375 4.1 4 1 small spleen 2.21576300986058e-09 1.25266147432459e-07 1.43651427729274 0.593406593406593 4.1 4 1 abnormal fetal cardiomyocyte proliferation 0.00110519548148258 0.0131382116111166 1.43454375016339 0.592592592592593 4.1 4 1 abnormal eye muscle morphology 0.00110519548148258 0.0131382116111166 1.43454375016339 0.592592592592593 4.1 4 1 abnormal vitelline vasculature morphology 2.42854144913557e-11 1.67805468186798e-09 1.43142517679347 0.591304347826087 4.1 4 1 decreased blood urea nitrogen level 3.56431164850953e-05 0.000741943533528656 1.43046834178225 0.590909090909091 4.1 4 1 increased skin papilloma incidence 0.00335915982484925 0.0327041489796967 1.43046834178225 0.590909090909091 4.1 4 1 abnormal sperm midpiece morphology 0.00335915982484925 0.0327041489796967 1.43046834178225 0.590909090909091 4.1 4 1 pulmonary vascular congestion 0.00335915982484925 0.0327041489796967 1.43046834178225 0.590909090909091 4.1 4 1 increased adenoma incidence 0.00335915982484925 0.0327041489796967 1.43046834178225 0.590909090909091 4.1 4 1 abnormal NK cell physiology 1.22949515807316e-06 3.84700529019747e-05 1.42866447249879 0.590163934426229 4.1 4 1 failure of heart looping 0.000104507875461189 0.00198445297870006 1.42764690521068 0.58974358974359 4.1 4 1 seminiferous tubule degeneration 1.25583108869904e-07 4.73315126233161e-06 1.42594631330454 0.589041095890411 4.1 4 1 oxidative stress 4.54076030484711e-09 2.353154428814e-07 1.42557785172487 0.588888888888889 4.1 4 1 abnormal embryo development 6.47571969139528e-13 5.8575828117621e-11 1.42399563435337 0.588235294117647 4.1 4 1 abnormal trophoblast layer morphology 1.0288826653945e-05 0.000255934563016881 1.42399563435337 0.588235294117647 4.1 4 1 enlarged liver sinusoidal spaces 0.000308582941863694 0.00484290263650435 1.42399563435337 0.588235294117647 4.1 4 1 increased regulatory T cell number 0.0104363488726477 0.0770338807736238 1.42399563435337 0.588235294117647 4.1 4 1 pancytopenia 0.0104363488726477 0.0770338807736238 1.42399563435337 0.588235294117647 4.1 4 1 abnormal circulating chemokine level 0.0104363488726477 0.0770338807736238 1.42399563435337 0.588235294117647 4.1 4 1 abnormal allantois morphology 2.99312443215494e-05 0.000647425828259601 1.42089999166999 0.58695652173913 4.1 4 1 abnormal embryonic erythropoiesis 0.000919603743675969 0.0115531025878483 1.41908530457974 0.586206896551724 4.1 4 1 polychromatophilia 0.000919603743675969 0.0115531025878483 1.41908530457974 0.586206896551724 4.1 4 1 blood in lymph vessels 0.000919603743675969 0.0115531025878483 1.41908530457974 0.586206896551724 4.1 4 1 increased leukocyte cell number 1.6385919600584e-13 1.66367244924297e-11 1.41908530457974 0.586206896551724 4.1 4 1 thrombocytopenia 1.6385919600584e-13 1.66367244924297e-11 1.41908530457974 0.586206896551724 4.1 4 1 decreased leukocyte cell number 1.11099371611262e-12 9.21198956276712e-11 1.41360150563546 0.583941605839416 4.1 4 1 small heart 2.5083249560867e-05 0.000559592675180778 1.41212900406709 0.583333333333333 4.1 4 1 thymus atrophy 2.5083249560867e-05 0.000559592675180778 1.41212900406709 0.583333333333333 4.1 4 1 hemolytic anemia 0.00277523798525858 0.0287641853680446 1.41212900406709 0.583333333333333 4.1 4 1 abnormal cellular extravasation 0.00277523798525858 0.0287641853680446 1.41212900406709 0.583333333333333 4.1 4 1 abnormal thymus involution 0.0336179389797693 0.19379982204444 1.41212900406709 0.583333333333333 4.1 4 1 abnormal embryonic growth/weight/body size 0.0336179389797693 0.19379982204444 1.41212900406709 0.583333333333333 4.1 4 1 increased growth rate 0.0336179389797693 0.19379982204444 1.41212900406709 0.583333333333333 4.1 4 1 abnormal defecation 0.0336179389797693 0.19379982204444 1.41212900406709 0.583333333333333 4.1 4 1 abnormal thymus corticomedullary boundary morphology 0.0336179389797693 0.19379982204444 1.41212900406709 0.583333333333333 4.1 4 1 decreased mammary gland epithelial cell proliferation 0.0336179389797693 0.19379982204444 1.41212900406709 0.583333333333333 4.1 4 1 persistent right dorsal aorta 0.0336179389797693 0.19379982204444 1.41212900406709 0.583333333333333 4.1 4 1 prenatal growth retardation 0.0336179389797693 0.19379982204444 1.41212900406709 0.583333333333333 4.1 4 1 abnormal placenta morphology 7.52116629574136e-08 2.99342418570506e-06 1.40957542539789 0.582278481012658 4.1 4 1 pale kidney 0.000763240573285761 0.00986778980585298 1.40562149713591 0.580645161290323 4.1 4 1 abnormal mitochondrial ATP synthesis coupled electron transport 0.000763240573285761 0.00986778980585298 1.40562149713591 0.580645161290323 4.1 4 1 microcephaly 6.15624810869332e-07 2.02830028746684e-05 1.40335801646419 0.579710144927536 4.1 4 1 decreased hair follicle number 0.000214250602117949 0.00351781104137556 1.40151149275832 0.578947368421053 4.1 4 1 incomplete somite formation 0.000214250602117949 0.00351781104137556 1.40151149275832 0.578947368421053 4.1 4 1 decreased neuron apoptosis 0.000214250602117949 0.00351781104137556 1.40151149275832 0.578947368421053 4.1 4 1 enlarged adrenal glands 0.00852874854955916 0.0669251167729603 1.40151149275832 0.578947368421053 4.1 4 1 decreased tumor incidence 0.00852874854955916 0.0669251167729603 1.40151149275832 0.578947368421053 4.1 4 1 oliguria 0.00852874854955916 0.0669251167729603 1.40151149275832 0.578947368421053 4.1 4 1 abnormal blastocyst morphology 0.00852874854955916 0.0669251167729603 1.40151149275832 0.578947368421053 4.1 4 1 shortened RR interval 0.00852874854955916 0.0669251167729603 1.40151149275832 0.578947368421053 4.1 4 1 impaired natural killer cell mediated cytotoxicity 6.06884061306622e-06 0.000160598308776619 1.40151149275831 0.578947368421053 4.1 4 1 abnormal placenta vasculature 1.7525698841742e-05 0.000413224415818325 1.3966111029235 0.576923076923077 4.1 4 1 kinked neural tube 1.7525698841742e-05 0.000413224415818325 1.3966111029235 0.576923076923077 4.1 4 1 heart inflammation 0.00228750897812175 0.0245266318236114 1.3966111029235 0.576923076923077 4.1 4 1 abnormal vascular development 1.47756113682445e-06 4.56575568677122e-05 1.39378966635193 0.575757575757576 4.1 4 1 abnormal T-helper 1 physiology 5.07782143732927e-05 0.00104389097730219 1.39066807695361 0.574468085106383 4.1 4 1 lethality throughout fetal growth and development, complete penetrance 5.58350180332269e-16 7.30997933461326e-14 1.38877047918779 0.573684210526316 4.1 4 1 abnormal immune system physiology 7.12855910748419e-11 4.5467412256069e-09 1.38609897634235 0.57258064516129 4.1 4 1 increased neutrophil cell number 1.87711059038831e-12 1.50622986890029e-10 1.38569506211904 0.572413793103448 4.1 4 1 abnormal cytotoxic T cell physiology 0.000147712156297625 0.00268552220152208 1.38331004480041 0.571428571428571 4.1 4 1 ovary cysts 0.000522818667841539 0.00717828370198663 1.38331004480041 0.571428571428571 4.1 4 1 abnormal midbrain development 0.000522818667841539 0.00717828370198663 1.38331004480041 0.571428571428571 4.1 4 1 abnormal embryonic epiblast morphology 0.000522818667841539 0.00717828370198663 1.38331004480041 0.571428571428571 4.1 4 1 increased red blood cell distribution width 0.000522818667841539 0.00717828370198663 1.38331004480041 0.571428571428571 4.1 4 1 abnormal eye pigmentation 0.00695900363506919 0.0588793249735871 1.38331004480041 0.571428571428571 4.1 4 1 trunk curl 0.00695900363506919 0.0588793249735871 1.38331004480041 0.571428571428571 4.1 4 1 increased acute inflammation 0.00695900363506919 0.0588793249735871 1.38331004480041 0.571428571428571 4.1 4 1 absent segment of posterior cerebral artery 0.00695900363506919 0.0588793249735871 1.38331004480041 0.571428571428571 4.1 4 1 small superior cervical ganglion 0.00188229532950372 0.020536007158511 1.38331004480041 0.571428571428571 4.1 4 1 abnormal spleen germinal center morphology 0.00188229532950372 0.020536007158511 1.38331004480041 0.571428571428571 4.1 4 1 abnormal mitotic spindle morphology 0.00188229532950372 0.020536007158511 1.38331004480041 0.571428571428571 4.1 4 1 increased lactate dehydrogenase level 0.026963874912755 0.163791547852205 1.38331004480041 0.571428571428571 4.1 4 1 abnormal viscerocranium morphology 0.026963874912755 0.163791547852205 1.38331004480041 0.571428571428571 4.1 4 1 abnormal glucose tolerance 0.026963874912755 0.163791547852205 1.38331004480041 0.571428571428571 4.1 4 1 decreased compact bone area 0.026963874912755 0.163791547852205 1.38331004480041 0.571428571428571 4.1 4 1 abnormal response to infection 2.52265922393322e-07 9.0289421863797e-06 1.3789324813675 0.569620253164557 4.1 4 1 abnormal spermiogenesis 1.01343164582134e-05 0.000255930072992953 1.37734750150386 0.568965517241379 4.1 4 1 abnormal extraembryonic tissue morphology 5.40425884145795e-09 2.77177193157251e-07 1.37652911320826 0.568627450980392 4.1 4 1 failure of chorioallantoic fusion 3.50799443336831e-05 0.00073950306381387 1.37652911320826 0.568627450980392 4.1 4 1 increased inflammatory response 1.82789199554496e-08 8.34290153929926e-07 1.37602946561725 0.568421052631579 4.1 4 1 muscular atrophy 0.00012240906906881 0.00228084314088888 1.37545032863678 0.568181818181818 4.1 4 1 increased circulating phosphate level 0.00043180879889283 0.00639359754313045 1.37396335530852 0.567567567567568 4.1 4 1 increased erythroid progenitor cell number 0.00043180879889283 0.00639359754313045 1.37396335530852 0.567567567567568 4.1 4 1 abnormal respiratory electron transport chain 0.00043180879889283 0.00639359754313045 1.37396335530852 0.567567567567568 4.1 4 1 gastrointestinal hemorrhage 0.00154691812484663 0.0174115784414298 1.37178246109374 0.566666666666667 4.1 4 1 increased mean corpuscular hemoglobin 1.27338843678386e-08 6.09144949326896e-07 1.36933721606506 0.565656565656566 4.1 4 1 decreased spleen weight 2.04035493009969e-06 6.04212248645592e-05 1.36827406605258 0.565217391304348 4.1 4 1 increased lymphocyte cell number 2.04035493009969e-06 6.04212248645592e-05 1.36827406605258 0.565217391304348 4.1 4 1 dilated heart 0.00567301141084719 0.0502192736102576 1.36827406605258 0.565217391304348 4.1 4 1 decreased effector memory CD8-positive, alpha-beta T cell number 0.00567301141084719 0.0502192736102576 1.36827406605258 0.565217391304348 4.1 4 1 abnormal vertebral artery topology 0.00567301141084719 0.0502192736102576 1.36827406605258 0.565217391304348 4.1 4 1 abnormal T-helper 2 physiology 2.41372791704472e-05 0.000543361827479524 1.36444672600768 0.563636363636364 4.1 4 1 vertebral transformation 8.38145977035547e-05 0.0016127575152514 1.36169582535041 0.5625 4.1 4 1 abnormal spongiotrophoblast layer morphology 0.00127011017673112 0.0148328594583036 1.36169582535041 0.5625 4.1 4 1 abnormal bone marrow cell number 0.0216459415061505 0.145328689599324 1.36169582535041 0.5625 4.1 4 1 disorganized yolk sac vascular plexus 0.0216459415061505 0.145328689599324 1.36169582535041 0.5625 4.1 4 1 large intestinal inflammation 0.0216459415061505 0.145328689599324 1.36169582535041 0.5625 4.1 4 1 impaired somite development 0.0216459415061505 0.145328689599324 1.36169582535041 0.5625 4.1 4 1 abnormal pulmonary alveolus wall morphology 0.0216459415061505 0.145328689599324 1.36169582535041 0.5625 4.1 4 1 incomplete embryo turning 1.99975680230409e-05 0.000458469589468334 1.35904144752321 0.56140350877193 4.1 4 1 abnormal developmental patterning 3.43728763962965e-07 1.19583958092011e-05 1.35800559276138 0.560975609756098 4.1 4 1 decreased circulating alkaline phosphatase level 6.92709027344947e-05 0.00136214522175538 1.35564384390441 0.56 4.1 4 1 abnormal egg cylinder morphology 0.00462235290123796 0.042040595399742 1.35564384390441 0.56 4.1 4 1 lung inflammation 7.75216316121328e-11 4.88190021861216e-09 1.3527958526357 0.558823529411765 4.1 4 1 abnormal direction of heart looping 0.00104210979106446 0.0127671508644841 1.3527958526357 0.558823529411765 4.1 4 1 impaired macrophage phagocytosis 0.000241946165464917 0.00390805900385703 1.35114004375854 0.558139534883721 4.1 4 1 abnormal placenta labyrinth morphology 8.05009998634633e-07 2.61759787137732e-05 1.34828953733711 0.556962025316456 4.1 4 1 hydrops fetalis 2.74082864917466e-06 7.83656467220916e-05 1.34488476577818 0.555555555555556 4.1 4 1 trabecula carnea hypoplasia 0.000199200010279634 0.00340281362129143 1.34488476577818 0.555555555555556 4.1 4 1 abnormal bile duct morphology 0.017396928343025 0.119378922077999 1.34488476577818 0.555555555555556 4.1 4 1 abnormal redox activity 0.017396928343025 0.119378922077999 1.34488476577818 0.555555555555556 4.1 4 1 abnormal neutrophil morphology 0.017396928343025 0.119378922077999 1.34488476577818 0.555555555555556 4.1 4 1 decreased lactate dehydrogenase level 0.017396928343025 0.119378922077999 1.34488476577818 0.555555555555556 4.1 4 1 abnormal macrophage chemotaxis 0.017396928343025 0.119378922077999 1.34488476577818 0.555555555555556 4.1 4 1 abnormal aerobic respiration 0.017396928343025 0.119378922077999 1.34488476577818 0.555555555555556 4.1 4 1 impaired leukocyte tethering or rolling 0.017396928343025 0.119378922077999 1.34488476577818 0.555555555555556 4.1 4 1 abnormal kindling response 0.0896567861136482 0.369546405066611 1.34488476577818 0.555555555555556 4.1 4 1 multifocal hepatic necrosis 0.0896567861136482 0.369546405066611 1.34488476577818 0.555555555555556 4.1 4 1 abnormal vomeronasal organ morphology 0.0896567861136482 0.369546405066611 1.34488476577818 0.555555555555556 4.1 4 1 abnormal thymus lobule morphology 0.0896567861136482 0.369546405066611 1.34488476577818 0.555555555555556 4.1 4 1 abnormal posterior semicircular canal morphology 0.0896567861136482 0.369546405066611 1.34488476577818 0.555555555555556 4.1 4 1 genetic imprinting 0.0896567861136482 0.369546405066611 1.34488476577818 0.555555555555556 4.1 4 1 abnormal artery development 0.0896567861136482 0.369546405066611 1.34488476577818 0.555555555555556 4.1 4 1 premature neuronal precursor differentiation 0.0896567861136482 0.369546405066611 1.34488476577818 0.555555555555556 4.1 4 1 short frontal bone 0.0896567861136482 0.369546405066611 1.34488476577818 0.555555555555556 4.1 4 1 liver hyperplasia 0.0896567861136482 0.369546405066611 1.34488476577818 0.555555555555556 4.1 4 1 abnormal liver vasculature morphology 0.0896567861136482 0.369546405066611 1.34488476577818 0.555555555555556 4.1 4 1 eye opacity 0.0896567861136482 0.369546405066611 1.34488476577818 0.555555555555556 4.1 4 1 abnormal pulmonary alveolar system morphology 0.0896567861136482 0.369546405066611 1.34488476577818 0.555555555555556 4.1 4 1 trigeminal neuroma 0.0896567861136482 0.369546405066611 1.34488476577818 0.555555555555556 4.1 4 1 abnormal infrahyoid muscle connection 0.0896567861136482 0.369546405066611 1.34488476577818 0.555555555555556 4.1 4 1 symmetric azygos veins 0.0896567861136482 0.369546405066611 1.34488476577818 0.555555555555556 4.1 4 1 abnormal atrioventricular cushion morphology 0.0037654008489207 0.0350147088287486 1.34488476577818 0.555555555555556 4.1 4 1 abnormal trigeminal ganglion morphology 0.0037654008489207 0.0350147088287486 1.34488476577818 0.555555555555556 4.1 4 1 decreased birth body size 5.64698605313117e-09 2.83775309235632e-07 1.33780642490566 0.552631578947368 4.1 4 1 decreased granulocyte number 0.00306714651206094 0.0314619667989757 1.33560969842799 0.551724137931034 4.1 4 1 increased susceptibility to induced arthritis 0.00306714651206094 0.0314619667989757 1.33560969842799 0.551724137931034 4.1 4 1 increased double-positive T cell number 0.00306714651206094 0.0314619667989757 1.33560969842799 0.551724137931034 4.1 4 1 increased sarcoma incidence 0.000134850612939419 0.00248474740508744 1.33390611462897 0.551020408163265 4.1 4 1 abnormal pericardium morphology 0.0139992104187147 0.0992109285371874 1.3314359181204 0.55 4.1 4 1 abnormal cell proliferation 0.0139992104187147 0.0992109285371874 1.3314359181204 0.55 4.1 4 1 abnormal physiological neovascularization 0.0139992104187147 0.0992109285371874 1.3314359181204 0.55 4.1 4 1 increased erythrocyte cell number 2.64944107372709e-05 0.000585820859635213 1.3314359181204 0.55 4.1 4 1 abnormal gastrulation 0.000110894678178962 0.00208189065637862 1.32906259206314 0.549019607843137 4.1 4 1 abnormal spermatogenesis 2.9734567372545e-13 2.95858945356823e-11 1.32880462183953 0.548913043478261 4.1 4 1 increased eosinophil cell number 2.18355700284293e-05 0.000498311747208421 1.32753141396169 0.548387096774194 4.1 4 1 lethality throughout fetal growth and development, incomplete penetrance 8.205234840515e-13 7.16158654939686e-11 1.32535012672219 0.547486033519553 4.1 4 1 osteoporosis 0.000385390681140245 0.00581005648082643 1.32043231549131 0.545454545454545 4.1 4 1 lethality, incomplete penetrance 0.000385390681140245 0.00581005648082643 1.32043231549131 0.545454545454545 4.1 4 1 abnormal abdominal fat pad morphology 0.0112788162073331 0.0820352494612315 1.32043231549131 0.545454545454545 4.1 4 1 abnormal oogenesis 0.0112788162073331 0.0820352494612315 1.32043231549131 0.545454545454545 4.1 4 1 testis hypoplasia 0.0112788162073331 0.0820352494612315 1.32043231549131 0.545454545454545 4.1 4 1 abnormal vascular branching morphogenesis 0.0112788162073331 0.0820352494612315 1.32043231549131 0.545454545454545 4.1 4 1 abnormal occipital bone morphology 0.0112788162073331 0.0820352494612315 1.32043231549131 0.545454545454545 4.1 4 1 decreased susceptibility to viral infection induced morbidity/mortality 0.0112788162073331 0.0820352494612315 1.32043231549131 0.545454545454545 4.1 4 1 abnormal large intestine morphology 0.0698241593684279 0.341904717379851 1.32043231549131 0.545454545454545 4.1 4 1 impaired myelopoiesis 0.0698241593684279 0.341904717379851 1.32043231549131 0.545454545454545 4.1 4 1 vasculitis 0.0698241593684279 0.341904717379851 1.32043231549131 0.545454545454545 4.1 4 1 abnormal palate development 0.0698241593684279 0.341904717379851 1.32043231549131 0.545454545454545 4.1 4 1 decreased palatine bone horizontal plate size 0.0698241593684279 0.341904717379851 1.32043231549131 0.545454545454545 4.1 4 1 increased number of Howell-Jolly bodies 0.0698241593684279 0.341904717379851 1.32043231549131 0.545454545454545 4.1 4 1 aorta dilation 0.0698241593684279 0.341904717379851 1.32043231549131 0.545454545454545 4.1 4 1 abnormal pulmonary alveolar sac morphology 0.0698241593684279 0.341904717379851 1.32043231549131 0.545454545454545 4.1 4 1 abnormal skeleton physiology 0.00203560511487751 0.0220634759183347 1.32043231549131 0.545454545454545 4.1 4 1 abnormal visceral yolk sac morphology 2.44516698727175e-06 7.11386301852454e-05 1.31764659330672 0.544303797468354 4.1 4 1 abnormal embryonic tissue morphology 1.46354141391299e-10 8.98903522742858e-09 1.31743813790516 0.54421768707483 4.1 4 1 increased macrophage cell number 6.15841150587576e-05 0.00123540714684403 1.31657140228811 0.543859649122807 4.1 4 1 increased neuron apoptosis 2.01629759684023e-06 6.04212248645592e-05 1.31499843764978 0.54320987654321 4.1 4 1 prenatal lethality, complete penetrance 1.67144894780636e-18 2.77181950511222e-16 1.31489093287234 0.543165467625899 4.1 4 1 holoprosencephaly 0.00165876799989166 0.0185030735413924 1.31414454256039 0.542857142857143 4.1 4 1 abnormal forebrain development 8.27300605329292e-06 0.000214365651641314 1.31126264663373 0.541666666666667 4.1 4 1 decreased body height 0.00909765273199743 0.0698469480581592 1.31126264663373 0.541666666666667 4.1 4 1 decreased metastatic potential 0.00909765273199743 0.0698469480581592 1.31126264663373 0.541666666666667 4.1 4 1 abnormal angiogenesis 6.80978926638817e-06 0.000178308955790953 1.30853652886526 0.540540540540541 4.1 4 1 small seminiferous tubules 6.80978926638817e-06 0.000178308955790953 1.30853652886526 0.540540540540541 4.1 4 1 anophthalmia 9.30686734477728e-07 2.93048512913082e-05 1.30559599733972 0.539325842696629 4.1 4 1 abnormal leukocyte cell number 0.00734633747820687 0.0595244771239074 1.30350369606193 0.538461538461538 4.1 4 1 abnormal erythrocyte osmotic lysis 0.00734633747820687 0.0595244771239074 1.30350369606193 0.538461538461538 4.1 4 1 abnormal Mullerian duct morphology 0.00734633747820687 0.0595244771239074 1.30350369606193 0.538461538461538 4.1 4 1 pulmonary edema 0.00734633747820687 0.0595244771239074 1.30350369606193 0.538461538461538 4.1 4 1 abnormal nerve conduction 0.00734633747820687 0.0595244771239074 1.30350369606193 0.538461538461538 4.1 4 1 tracheoesophageal fistula 0.0547809402932863 0.288092154290803 1.30350369606193 0.538461538461538 4.1 4 1 small otic vesicle 0.0547809402932863 0.288092154290803 1.30350369606193 0.538461538461538 4.1 4 1 increased circulating ammonia level 0.0547809402932863 0.288092154290803 1.30350369606193 0.538461538461538 4.1 4 1 decreased trabecular bone volume 0.00110222481095766 0.0131382116111166 1.30350369606193 0.538461538461538 4.1 4 1 internal hemorrhage 2.30438414349974e-05 0.00052348452574937 1.30072437048397 0.537313432835821 4.1 4 1 increased cell proliferation 0.000142142809890357 0.00259985470295781 1.30005527358558 0.537037037037037 4.1 4 1 abnormal ovary morphology 1.55450371045224e-05 0.000375551159160923 1.29563546449616 0.535211267605634 4.1 4 1 dermatitis 9.5393817848613e-05 0.00181833043600326 1.29387189535211 0.53448275862069 4.1 4 1 abnormal myocardial trabeculae morphology 0.000598180019266657 0.0080868086843794 1.29108937514705 0.533333333333333 4.1 4 1 small placenta 0.000598180019266657 0.0080868086843794 1.29108937514705 0.533333333333333 4.1 4 1 arrested T cell differentiation 0.00480455038316303 0.0433018807178189 1.29108937514705 0.533333333333333 4.1 4 1 salivary gland inflammation 0.00480455038316303 0.0433018807178189 1.29108937514705 0.533333333333333 4.1 4 1 disorganized myocardium 0.00480455038316303 0.0433018807178189 1.29108937514705 0.533333333333333 4.1 4 1 liver hemorrhage 0.00480455038316303 0.0433018807178189 1.29108937514705 0.533333333333333 4.1 4 1 abnormal optic cup morphology 0.00480455038316303 0.0433018807178189 1.29108937514705 0.533333333333333 4.1 4 1 decreased hepatocyte number 0.0432226256011103 0.237867878722925 1.29108937514705 0.533333333333333 4.1 4 1 abnormal prostate gland morphology 0.0432226256011103 0.237867878722925 1.29108937514705 0.533333333333333 4.1 4 1 abnormal energy homeostasis 0.0432226256011103 0.237867878722925 1.29108937514705 0.533333333333333 4.1 4 1 bicuspid aortic valve 0.0432226256011103 0.237867878722925 1.29108937514705 0.533333333333333 4.1 4 1 abnormal microglial cell activation 0.0432226256011103 0.237867878722925 1.29108937514705 0.533333333333333 4.1 4 1 decreased trabecular bone mass 0.0432226256011103 0.237867878722925 1.29108937514705 0.533333333333333 4.1 4 1 heterochrony 0.0432226256011103 0.237867878722925 1.29108937514705 0.533333333333333 4.1 4 1 pericardial effusion 6.40354628579408e-05 0.00127330718931554 1.28848637237458 0.532258064516129 4.1 4 1 decreased hemoglobin content 2.14427205554801e-09 1.22617856050016e-07 1.2876556268089 0.531914893617021 4.1 4 1 neuron degeneration 0.000488180139498317 0.006979012051736 1.2876556268089 0.531914893617021 4.1 4 1 decreased bone trabecula number 0.000488180139498317 0.006979012051736 1.2876556268089 0.531914893617021 4.1 4 1 increased sacral vertebrae number 5.24707277938319e-05 0.00106984373268161 1.28604605727539 0.53125 4.1 4 1 increased fatty acid level 0.00389073183770664 0.0360454206565932 1.28604605727539 0.53125 4.1 4 1 decreased circulating creatinine level 0.000398510780268427 0.00597720345115658 1.28450218445753 0.530612244897959 4.1 4 1 decreased circulating alanine transaminase level 3.52379974816096e-05 0.000739700580046447 1.28159607091803 0.529411764705882 4.1 4 1 abnormal brown adipose tissue morphology 0.00315328735416722 0.0319503148411037 1.28159607091803 0.529411764705882 4.1 4 1 decreased cytotoxic T cell cytolysis 0.00315328735416722 0.0319503148411037 1.28159607091803 0.529411764705882 4.1 4 1 increased susceptibility to viral infection induced morbidity/mortality 0.00315328735416722 0.0319503148411037 1.28159607091803 0.529411764705882 4.1 4 1 abnormal adipose tissue morphology 0.0342567332188411 0.195893388234178 1.28159607091803 0.529411764705882 4.1 4 1 abnormal dorsal-ventral axis patterning 0.0342567332188411 0.195893388234178 1.28159607091803 0.529411764705882 4.1 4 1 abnormal melanosome morphology 0.0342567332188411 0.195893388234178 1.28159607091803 0.529411764705882 4.1 4 1 enhanced behavioral response to cocaine 0.0342567332188411 0.195893388234178 1.28159607091803 0.529411764705882 4.1 4 1 abnormal cell cytoskeleton morphology 0.0342567332188411 0.195893388234178 1.28159607091803 0.529411764705882 4.1 4 1 abnormal placenta development 0.000265757355697415 0.00425126316589916 1.27890928670227 0.528301886792453 4.1 4 1 abnormal pharyngeal arch morphology 0.00255754766304642 0.0269097219603369 1.27764052748927 0.527777777777778 4.1 4 1 increased grip strength 2.17035445151764e-06 6.38906118124276e-05 1.27690157981577 0.527472527472527 4.1 4 1 abnormal coat/hair pigmentation 1.66464046313163e-07 6.08940169417637e-06 1.27523894755038 0.526785714285714 4.1 4 1 decreased brain weight 0.000177396111051884 0.00311180404925181 1.27410135705301 0.526315789473684 4.1 4 1 altered susceptibility to infection 0.027250461446876 0.164648278078482 1.27410135705301 0.526315789473684 4.1 4 1 increased susceptibility to ischemic brain injury 0.027250461446876 0.164648278078482 1.27410135705301 0.526315789473684 4.1 4 1 preweaning lethality, incomplete penetrance 2.6784275901973e-23 8.32823578826973e-21 1.27254377593192 0.525672371638142 4.1 4 1 abnormal pancreatic beta cell morphology 0.00168591516647057 0.0187638209243649 1.27091610366038 0.525 4.1 4 1 disheveled coat 0.00137008161074416 0.0155976110147647 1.26803420773371 0.523809523809524 4.1 4 1 increased incidence of induced tumors 0.0217434378807247 0.145786527569549 1.26803420773371 0.523809523809524 4.1 4 1 prenatal lethality, incomplete penetrance 2.40559506007081e-17 3.62661679510675e-15 1.26613822357143 0.523026315789474 4.1 4 1 increased bone mineral content 3.69461293769141e-07 1.26763443896653e-05 1.26591905476001 0.522935779816514 4.1 4 1 abnormal hepatocyte morphology 3.03516541042245e-07 1.0709182919753e-05 1.26491864456975 0.522522522522523 4.1 4 1 pancreas inflammation 0.0173942396216814 0.119378922077999 1.26302221481777 0.521739130434783 4.1 4 1 decreased neutrophil cell number 1.68301700485594e-07 6.11168583880169e-06 1.26212262634568 0.521367521367521 4.1 4 1 overriding aortic valve 0.000737713479179306 0.00960765591339541 1.26082946791704 0.520833333333333 4.1 4 1 abnormal lymph node morphology 0.000737713479179306 0.00960765591339541 1.26082946791704 0.520833333333333 4.1 4 1 mandible hypoplasia 0.0139458942153201 0.0992109285371874 1.25881214076838 0.52 4.1 4 1 neurodegeneration 0.000398880712720399 0.00597720345115658 1.25522578139297 0.518518518518518 4.1 4 1 decreased bone ossification 0.0112027307712843 0.0820352494612315 1.25522578139297 0.518518518518518 4.1 4 1 lordosis 0.00901435962163526 0.0698209513218732 1.25213409227624 0.517241379310345 4.1 4 1 decreased trophoblast giant cell number 0.00901435962163526 0.0698209513218732 1.25213409227624 0.517241379310345 4.1 4 1 intracranial hemorrhage 0.000216422315730525 0.00354177967355053 1.25074283217371 0.516666666666667 4.1 4 1 increased lung adenoma incidence 0.00726430910620263 0.0595244771239074 1.24944133078747 0.516129032258065 4.1 4 1 azoospermia 2.72803984571323e-09 1.50799980360259e-07 1.24845906559031 0.515723270440252 4.1 4 1 decreased brown adipose tissue amount 0.00586180398071262 0.0513423852183896 1.24707496463068 0.515151515151515 4.1 4 1 increased osteoblast cell number 0.00586180398071262 0.0513423852183896 1.24707496463068 0.515151515151515 4.1 4 1 increased susceptibility to bacterial infection induced morbidity/mortality 6.42412270388342e-05 0.00127330718931554 1.24401840834482 0.513888888888889 4.1 4 1 decreased hematocrit 1.58255026782444e-08 7.42753545511944e-07 1.24355783137024 0.513698630136986 4.1 4 1 abnormal leukocyte adhesion 0.00310064329095716 0.0317401242232754 1.24143209148755 0.512820512820513 4.1 4 1 increased circulating alkaline phosphatase level 3.28388718756862e-09 1.75670309227461e-07 1.24028261732877 0.512345679012346 4.1 4 1 Leydig cell hyperplasia 0.00251235621522773 0.0267072054930726 1.23991814991257 0.51219512195122 4.1 4 1 thick ventricular wall 0.00251235621522773 0.0267072054930726 1.23991814991257 0.51219512195122 4.1 4 1 abnormal blood vessel morphology 2.81211638611798e-08 1.2165460018206e-06 1.23543897104589 0.510344827586207 4.1 4 1 abnormal mesoderm development 0.000721674567600903 0.00949195950670116 1.23323395503433 0.509433962264151 4.1 4 1 decreased circulating calcium level 0.000587391561540489 0.00798435251001074 1.23240349445855 0.509090909090909 4.1 4 1 decreased susceptibility to induced arthritis 0.000478320571860998 0.0068775862572499 1.23163131181791 0.508771929824561 4.1 4 1 decreased susceptibility to hepatic steatosis 0.000258938046971231 0.00415553801187701 1.22960892871148 0.507936507936508 4.1 4 1 ventricular septal defect 1.09425975358195e-07 4.15568112524443e-06 1.22819623462978 0.507352941176471 4.1 4 1 small testis 4.57541039718082e-14 5.29364342464525e-12 1.22793826440617 0.507246376811594 4.1 4 1 perimembraneous ventricular septal defect 0.00014063817370041 0.00258182625151121 1.22793826440617 0.507246376811594 4.1 4 1 decreased percent body fat/body weight 9.3767556215382e-05 0.00179420612373664 1.2269770602853 0.506849315068493 4.1 4 1 abnormal heart morphology 6.01070278636181e-12 4.53079490335606e-10 1.22611572152764 0.506493506493506 4.1 4 1 abnormal nervous system morphology 5.11508764835131e-05 0.00104722473459044 1.22571776121556 0.506329113924051 4.1 4 1 abnormal neural tube morphology 8.41567011005713e-09 4.10470184289551e-07 1.22533945326457 0.506172839506173 4.1 4 1 embryonic lethality during organogenesis, incomplete penetrance 1.05233805197709e-11 7.58750986751595e-10 1.22092147432384 0.504347826086956 4.1 4 1 hemorrhage 1.01785055850063e-11 7.55792019185166e-10 1.2155469117076 0.502127659574468 4.1 4 1 abnormal seminiferous tubule morphology 1.02211349117683e-07 3.97266767078496e-06 1.21039628920036 0.5 4.1 4 1 decreased circulating glycerol level 0.0205454509524333 0.139445591389298 1.21039628920036 0.5 4.1 4 1 abnormal chorion morphology 0.0322080595541164 0.18762891836268 1.21039628920036 0.5 4.1 4 1 abnormal cerebral cortex pyramidal cell morphology 0.0322080595541164 0.18762891836268 1.21039628920036 0.5 4.1 4 1 rough coat 0.0322080595541164 0.18762891836268 1.21039628920036 0.5 4.1 4 1 perinatal lethality, incomplete penetrance 3.87654648035328e-11 2.64189297804898e-09 1.21039628920036 0.5 4.1 4 1 abnormal osteoclast physiology 0.000373668407706163 0.00566768392786024 1.21039628920036 0.5 4.1 4 1 prenatal lethality 0.000458540999736014 0.00668985769409581 1.21039628920036 0.5 4.1 4 1 absent mesoderm 0.000562926919247367 0.00767277102261822 1.21039628920036 0.5 4.1 4 1 diluted coat color 0.00104446842248141 0.0127671508644841 1.21039628920036 0.5 4.1 4 1 decreased tumor growth/size 0.00104446842248141 0.0127671508644841 1.21039628920036 0.5 4.1 4 1 abnormal neuronal precursor proliferation 0.00104446842248141 0.0127671508644841 1.21039628920036 0.5 4.1 4 1 axon degeneration 0.00104446842248141 0.0127671508644841 1.21039628920036 0.5 4.1 4 1 decreased platelet aggregation 0.00104446842248141 0.0127671508644841 1.21039628920036 0.5 4.1 4 1 abnormal myelin sheath morphology 0.0024003821101358 0.0256263969912566 1.21039628920036 0.5 4.1 4 1 abnormal pancreas morphology 0.0036546308197113 0.0341121732233841 1.21039628920036 0.5 4.1 4 1 abnormal reproductive system morphology 0.0036546308197113 0.0341121732233841 1.21039628920036 0.5 4.1 4 1 decreased total retina thickness 0.00558433916830238 0.0496996196105623 1.21039628920036 0.5 4.1 4 1 failure of primitive streak formation 0.0106378863746986 0.0784051625394454 1.21039628920036 0.5 4.1 4 1 abnormal brain vasculature morphology 0.0132241688601075 0.0943905883486869 1.21039628920036 0.5 4.1 4 1 abnormal fat pad morphology 0.0132241688601075 0.0943905883486869 1.21039628920036 0.5 4.1 4 1 abnormal cellular respiration 0.0132241688601075 0.0943905883486869 1.21039628920036 0.5 4.1 4 1 abnormal tumor morphology 0.0256908265113654 0.158318399221077 1.21039628920036 0.5 4.1 4 1 increased urine glucose level 0.0405017124750374 0.228674955003138 1.21039628920036 0.5 4.1 4 1 decreased myocardial infarction size 0.0405017124750374 0.228674955003138 1.21039628920036 0.5 4.1 4 1 abnormal optic stalk morphology 0.0405017124750374 0.228674955003138 1.21039628920036 0.5 4.1 4 1 dilated vasculature 0.0405017124750374 0.228674955003138 1.21039628920036 0.5 4.1 4 1 absent ductus venosus valve 0.0405017124750374 0.228674955003138 1.21039628920036 0.5 4.1 4 1 underdeveloped hair follicles 0.0511165380946572 0.275221620152511 1.21039628920036 0.5 4.1 4 1 abnormal iron level 0.0511165380946572 0.275221620152511 1.21039628920036 0.5 4.1 4 1 darkened coat color 0.0511165380946572 0.275221620152511 1.21039628920036 0.5 4.1 4 1 decreased fluid intake 0.0511165380946572 0.275221620152511 1.21039628920036 0.5 4.1 4 1 increased adipocyte glucose uptake 0.0511165380946572 0.275221620152511 1.21039628920036 0.5 4.1 4 1 abnormal olfaction 0.0647993096960703 0.321412328751695 1.21039628920036 0.5 4.1 4 1 increased pancreatic beta cell number 0.0647993096960703 0.321412328751695 1.21039628920036 0.5 4.1 4 1 abnormal molar crown morphology 0.0647993096960703 0.321412328751695 1.21039628920036 0.5 4.1 4 1 increased cochlear outer hair cell number 0.0647993096960703 0.321412328751695 1.21039628920036 0.5 4.1 4 1 sepsis 0.0647993096960703 0.321412328751695 1.21039628920036 0.5 4.1 4 1 dystonia 0.0647993096960703 0.321412328751695 1.21039628920036 0.5 4.1 4 1 decreased creatinine clearance 0.0647993096960703 0.321412328751695 1.21039628920036 0.5 4.1 4 1 embryonic lethality between somite formation and embryo turning, incomplete penetrance 0.0647993096960703 0.321412328751695 1.21039628920036 0.5 4.1 4 1 decreased midbrain size 0.0647993096960703 0.321412328751695 1.21039628920036 0.5 4.1 4 1 abnormal pilomotor reflex 0.106030379757087 0.425061353176072 1.21039628920036 0.5 4.1 4 1 increased papilloma incidence 0.106030379757087 0.425061353176072 1.21039628920036 0.5 4.1 4 1 dilated bile duct 0.106030379757087 0.425061353176072 1.21039628920036 0.5 4.1 4 1 increased hepatocyte proliferation 0.106030379757087 0.425061353176072 1.21039628920036 0.5 4.1 4 1 decreased red blood cell distribution width 0.106030379757087 0.425061353176072 1.21039628920036 0.5 4.1 4 1 abnormal pulmonary valve cusp morphology 0.106030379757087 0.425061353176072 1.21039628920036 0.5 4.1 4 1 abnormal respiratory motile cilium morphology 0.106030379757087 0.425061353176072 1.21039628920036 0.5 4.1 4 1 increased cranium width 0.137393031921839 0.515871950046149 1.21039628920036 0.5 4.1 4 1 abnormal mammary gland physiology 0.137393031921839 0.515871950046149 1.21039628920036 0.5 4.1 4 1 abnormal airway responsiveness 0.137393031921839 0.515871950046149 1.21039628920036 0.5 4.1 4 1 peritoneal inflammation 0.137393031921839 0.515871950046149 1.21039628920036 0.5 4.1 4 1 abnormal submandibular gland morphology 0.137393031921839 0.515871950046149 1.21039628920036 0.5 4.1 4 1 abnormal reproductive system development 0.137393031921839 0.515871950046149 1.21039628920036 0.5 4.1 4 1 abnormal embryonic erythrocyte morphology 0.137393031921839 0.515871950046149 1.21039628920036 0.5 4.1 4 1 abnormal deltoid tuberosity morphology 0.137393031921839 0.515871950046149 1.21039628920036 0.5 4.1 4 1 osteosclerosis 0.137393031921839 0.515871950046149 1.21039628920036 0.5 4.1 4 1 increased platelet aggregation 0.137393031921839 0.515871950046149 1.21039628920036 0.5 4.1 4 1 abnormal hippocampus neuron morphology 0.137393031921839 0.515871950046149 1.21039628920036 0.5 4.1 4 1 abnormal inferior vena cava valve morphology 0.137393031921839 0.515871950046149 1.21039628920036 0.5 4.1 4 1 thick aortic valve 0.137393031921839 0.515871950046149 1.21039628920036 0.5 4.1 4 1 abnormal adaptive thermogenesis 0.137393031921839 0.515871950046149 1.21039628920036 0.5 4.1 4 1 decreased circulating lactate level 0.137393031921839 0.515871950046149 1.21039628920036 0.5 4.1 4 1 abnormal circulating protein level 0.00158135690317826 0.0177590306846768 1.21039628920036 0.5 4.1 4 1 abnormal somite shape 0.0164672466327822 0.114260184097756 1.21039628920036 0.5 4.1 4 1 abnormal brainstem morphology 0.0164672466327822 0.114260184097756 1.21039628920036 0.5 4.1 4 1 midline facial cleft 0.0825980056738178 0.357842705637067 1.21039628920036 0.5 4.1 4 1 absent visceral yolk sac blood islands 0.0825980056738178 0.357842705637067 1.21039628920036 0.5 4.1 4 1 abnormal adrenal gland secretion 0.0825980056738178 0.357842705637067 1.21039628920036 0.5 4.1 4 1 absent otoliths 0.0825980056738178 0.357842705637067 1.21039628920036 0.5 4.1 4 1 amyloid beta deposits 0.0825980056738178 0.357842705637067 1.21039628920036 0.5 4.1 4 1 abnormal vascular endothelial cell migration 0.0825980056738178 0.357842705637067 1.21039628920036 0.5 4.1 4 1 abnormal sagittal suture morphology 0.0825980056738178 0.357842705637067 1.21039628920036 0.5 4.1 4 1 abnormal positive T cell selection 0.0825980056738178 0.357842705637067 1.21039628920036 0.5 4.1 4 1 spina bifida occulta 0.0825980056738178 0.357842705637067 1.21039628920036 0.5 4.1 4 1 increased lung compliance 0.0825980056738178 0.357842705637067 1.21039628920036 0.5 4.1 4 1 abnormal testis morphology 3.46803071854272e-06 9.63880046075421e-05 1.19987110407688 0.495652173913044 4.1 4 1 abnormal heart development 7.62948991441178e-08 3.01243748604751e-06 1.19507481718517 0.493670886075949 4.1 4 1 gliosis 0.000651906360226898 0.00864862437901018 1.19118364968925 0.492063492063492 4.1 4 1 abnormal male meiosis 0.00080035121448877 0.0103154074924395 1.19055372708232 0.491803278688525 4.1 4 1 cachexia 1.61561280114055e-05 0.000388293414766872 1.18711943748497 0.490384615384615 4.1 4 1 abnormal respiratory system physiology 0.00276992954769211 0.0287641853680446 1.18569432411464 0.489795918367347 4.1 4 1 abnormal craniofacial development 0.00276992954769211 0.0287641853680446 1.18569432411464 0.489795918367347 4.1 4 1 increased respiratory quotient 0.00341402552123585 0.0331733925159148 1.18464317666418 0.48936170212766 4.1 4 1 hemopericardium 0.00642300493945899 0.0557669277029817 1.18087442848816 0.48780487804878 4.1 4 1 impaired macrophage chemotaxis 0.00794385025178036 0.063589708738586 1.17936048691317 0.487179487179487 4.1 4 1 abnormal branching of the mammary ductal tree 0.00983540081592943 0.0730315209839536 1.17768287597873 0.486486486486487 4.1 4 1 increased circulating serum albumin level 0.0121918882142348 0.0880409618670333 1.17581353808035 0.485714285714286 4.1 4 1 decreased glycogen level 0.0121918882142348 0.0880409618670333 1.17581353808035 0.485714285714286 4.1 4 1 abnormal hippocampus pyramidal cell morphology 0.0121918882142348 0.0880409618670333 1.17581353808035 0.485714285714286 4.1 4 1 enlarged pericardium 0.015133022745509 0.106638510140095 1.17371761377005 0.484848484848485 4.1 4 1 abnormal QRS complex 0.015133022745509 0.106638510140095 1.17371761377005 0.484848484848485 4.1 4 1 decreased circulating LDL cholesterol level 0.00091328140653425 0.0115531025878483 1.17257140516285 0.484375 4.1 4 1 decreased caudal vertebrae number 0.00091328140653425 0.0115531025878483 1.17257140516285 0.484375 4.1 4 1 abnormal tooth morphology 0.00091328140653425 0.0115531025878483 1.17257140516285 0.484375 4.1 4 1 abnormal behavior 1.78826420219138e-11 1.25304428252142e-09 1.16685685433704 0.482014388489209 4.1 4 1 abnormal small intestine morphology 0.00255374893204227 0.0269097219603369 1.16556679700776 0.481481481481481 4.1 4 1 abnormal cell adhesion 0.00255374893204227 0.0269097219603369 1.16556679700776 0.481481481481481 4.1 4 1 thick interventricular septum 0.0292208339777859 0.171027822399394 1.16556679700776 0.481481481481481 4.1 4 1 distended pericardium 0.00314160382223734 0.0319503148411037 1.16384258576958 0.480769230769231 4.1 4 1 abnormal female meiosis 0.00314160382223734 0.0319503148411037 1.16384258576958 0.480769230769231 4.1 4 1 kyphosis 9.27525810039929e-07 2.93048512913082e-05 1.16198043763235 0.48 4.1 4 1 abnormal liver physiology 5.66436559754999e-05 0.00114553735153704 1.16198043763235 0.48 4.1 4 1 kidney inflammation 0.00386707352724335 0.0358930798470815 1.16198043763235 0.48 4.1 4 1 abnormal feces composition 0.0365323024769456 0.207949891101607 1.16198043763235 0.48 4.1 4 1 decreased acute inflammation 0.0365323024769456 0.207949891101607 1.16198043763235 0.48 4.1 4 1 premature death 7.39978975054254e-32 4.09043933432768e-29 1.16119318801336 0.479674796747967 4.1 4 1 astrocytosis 0.000559848093257654 0.00765176995592535 1.16065397594555 0.479452054794521 4.1 4 1 abnormal cardiovascular development 0.0457873944921818 0.25004641887882 1.15777036358296 0.478260869565217 4.1 4 1 abnormal Wolffian duct morphology 0.0457873944921818 0.25004641887882 1.15777036358296 0.478260869565217 4.1 4 1 decreased body length 6.01366492133095e-11 3.88545233553526e-09 1.15738623273903 0.478102189781022 4.1 4 1 decreased white adipose tissue amount 0.00102922473605942 0.0127671508644841 1.1561994404302 0.477611940298507 4.1 4 1 cochlear hair cell degeneration 0.00724160870984557 0.0595244771239074 1.15537827605489 0.477272727272727 4.1 4 1 abnormal salivary gland morphology 0.0575546893789579 0.299513158640498 1.15275837066701 0.476190476190476 4.1 4 1 left pulmonary isomerism 0.0575546893789579 0.299513158640498 1.15275837066701 0.476190476190476 4.1 4 1 vascular ring 0.0575546893789579 0.299513158640498 1.15275837066701 0.476190476190476 4.1 4 1 decreased total body fat amount 8.94915140048395e-13 7.67621176162201e-11 1.15241323343029 0.476047904191617 4.1 4 1 kyphoscoliosis 0.0725960070776603 0.353045097958319 1.14669122134771 0.473684210526316 4.1 4 1 abnormal triglyceride level 0.0725960070776603 0.353045097958319 1.14669122134771 0.473684210526316 4.1 4 1 abnormal stationary movement 0.0725960070776603 0.353045097958319 1.14669122134771 0.473684210526316 4.1 4 1 abnormal nasal septum morphology 0.0725960070776603 0.353045097958319 1.14669122134771 0.473684210526316 4.1 4 1 absent amnion 0.0725960070776603 0.353045097958319 1.14669122134771 0.473684210526316 4.1 4 1 Leydig cell hypoplasia 0.0725960070776603 0.353045097958319 1.14669122134771 0.473684210526316 4.1 4 1 increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 0.0725960070776603 0.353045097958319 1.14669122134771 0.473684210526316 4.1 4 1 abnormal head morphology 0.00351173939334741 0.0338563799270049 1.1443746734258 0.472727272727273 4.1 4 1 abnormal rostral-caudal axis patterning 0.00351173939334741 0.0338563799270049 1.1443746734258 0.472727272727273 4.1 4 1 abnormal platelet physiology 0.00351173939334741 0.0338563799270049 1.1443746734258 0.472727272727273 4.1 4 1 decreased rib number 0.000255831251831852 0.00411896594777821 1.14239649767225 0.471910112359551 4.1 4 1 abnormal coat/ hair morphology 0.00431530516679943 0.0393920058804168 1.14188329169846 0.471698113207547 4.1 4 1 increased circulating bilirubin level 0.00431530516679943 0.0393920058804168 1.14188329169846 0.471698113207547 4.1 4 1 abnormal bone structure 1.05175938087294e-07 4.05620381383169e-06 1.14140997219931 0.471502590673575 4.1 4 1 lung hemorrhage 0.0209665357572877 0.141916347472797 1.13919650748269 0.470588235294118 4.1 4 1 decreased regulatory T cell number 0.0209665357572877 0.141916347472797 1.13919650748269 0.470588235294118 4.1 4 1 abnormal interatrial septum morphology 0.0919482665647184 0.376806117100061 1.13919650748269 0.470588235294118 4.1 4 1 increased incidence of corneal inflammation 0.0919482665647184 0.376806117100061 1.13919650748269 0.470588235294118 4.1 4 1 increased hepatoma incidence 0.0919482665647184 0.376806117100061 1.13919650748269 0.470588235294118 4.1 4 1 enlarged liver 0.00012818552638785 0.00237071744899462 1.13777251184834 0.47 4.1 4 1 abnormal lipid level 0.000465557884219446 0.00671347963475868 1.13748085009191 0.469879518072289 4.1 4 1 reduced female fertility 7.85867128976129e-09 3.87097917490717e-07 1.13735513381758 0.469827586206897 4.1 4 1 male infertility 2.66527359989357e-17 3.89992239984427e-15 1.13579930119795 0.469184890656064 4.1 4 1 scoliosis 0.0260235823835356 0.159836200442086 1.13474652112534 0.46875 4.1 4 1 decreased susceptibility to parasitic infection 0.0260235823835356 0.159836200442086 1.13474652112534 0.46875 4.1 4 1 weight loss 6.02738652138249e-07 1.99908319625852e-05 1.13431423673634 0.468571428571429 4.1 4 1 increased heart weight 9.11622594846371e-06 0.000233779505637149 1.13202530644638 0.467625899280576 4.1 4 1 abnormal locomotor behavior 0.000283089079973526 0.00448524895817927 1.13145740077425 0.467391304347826 4.1 4 1 thin ventricular wall 0.000345172489854438 0.00533302216467649 1.12970320325367 0.466666666666667 4.1 4 1 increased susceptibility to parasitic infection 0.000345172489854438 0.00533302216467649 1.12970320325367 0.466666666666667 4.1 4 1 abnormal neurocranium morphology 0.001036538890791 0.0127671508644841 1.12970320325367 0.466666666666667 4.1 4 1 abnormal ectoderm development 0.00989334109853541 0.0733522682044913 1.12970320325367 0.466666666666667 4.1 4 1 muscular ventricular septal defect 0.00316264749592414 0.031980022951672 1.12970320325367 0.466666666666667 4.1 4 1 placental labyrinth hypoplasia 0.117051463237437 0.454946116879881 1.12970320325367 0.466666666666667 4.1 4 1 joint inflammation 0.117051463237437 0.454946116879881 1.12970320325367 0.466666666666667 4.1 4 1 herniated liver 0.117051463237437 0.454946116879881 1.12970320325367 0.466666666666667 4.1 4 1 abnormal brain morphology 2.33982519798686e-06 6.84742962352036e-05 1.12769840608729 0.46583850931677 4.1 4 1 increased oxygen consumption 0.000513310301898787 0.00717828370198663 1.12595003646545 0.465116279069767 4.1 4 1 abnormal homeostasis 0.0121930095932434 0.0880409618670333 1.12595003646545 0.465116279069767 4.1 4 1 arrest of spermatogenesis 0.0006260554277365 0.00837264987362658 1.12393941140034 0.464285714285714 4.1 4 1 abnormal liver morphology 8.86221127201807e-07 2.82625006912115e-05 1.12249041344838 0.463687150837989 4.1 4 1 sparse hair 0.00076363800507606 0.00986778980585298 1.12183070706375 0.463414634146341 4.1 4 1 increased bone trabecula number 0.0150382275096212 0.106271565142564 1.12183070706375 0.463414634146341 4.1 4 1 decreased bone resorption 0.0502353180693849 0.272244779297592 1.1172888823388 0.461538461538462 4.1 4 1 short premaxilla 0.149958470726058 0.54705757610857 1.1172888823388 0.461538461538462 4.1 4 1 absent common myeloid progenitor cells 0.149958470726058 0.54705757610857 1.1172888823388 0.461538461538462 4.1 4 1 abnormal grip strength 0.149958470726058 0.54705757610857 1.1172888823388 0.461538461538462 4.1 4 1 abnormal digestion 0.149958470726058 0.54705757610857 1.1172888823388 0.461538461538462 4.1 4 1 abnormal pulmonary alveolus epithelial cell morphology 0.149958470726058 0.54705757610857 1.1172888823388 0.461538461538462 4.1 4 1 abnormal bile duct development 0.149958470726058 0.54705757610857 1.1172888823388 0.461538461538462 4.1 4 1 increased cochlear inner hair cell number 0.149958470726058 0.54705757610857 1.1172888823388 0.461538461538462 4.1 4 1 increased circulating thyroxine level 0.149958470726058 0.54705757610857 1.1172888823388 0.461538461538462 4.1 4 1 increased prostaglandin level 0.149958470726058 0.54705757610857 1.1172888823388 0.461538461538462 4.1 4 1 abnormal aorta tunica media morphology 0.149958470726058 0.54705757610857 1.1172888823388 0.461538461538462 4.1 4 1 abnormal lipid homeostasis 3.2151118955391e-05 0.000680646028949236 1.1172888823388 0.461538461538462 4.1 4 1 increased rib number 0.00113649283852664 0.0134300519517103 1.1172888823388 0.461538461538462 4.1 4 1 enlarged heart 3.64198388540952e-08 1.54862135298396e-06 1.11648623227965 0.461206896551724 4.1 4 1 postnatal growth retardation 4.88685274550521e-19 9.00447866995868e-17 1.11546324691014 0.46078431372549 4.1 4 1 increased circulating aspartate transaminase level 0.00346208560175941 0.0335748067617019 1.11433309164478 0.46031746031746 4.1 4 1 short stride length 0.00879160874380156 0.0686628783365978 1.11356458606433 0.46 4.1 4 1 abnormal retinal pigmentation 0.000684386354196988 0.00903135838761277 1.11300808202332 0.459770114942529 4.1 4 1 decreased circulating chloride level 0.0229313759116693 0.15090422640285 1.11225604953547 0.459459459459459 4.1 4 1 increased trabecular bone volume 0.0229313759116693 0.15090422640285 1.11225604953547 0.459459459459459 4.1 4 1 edema 2.53144543977991e-06 7.32205875750293e-05 1.11187566100964 0.459302325581395 4.1 4 1 increased osteoclast cell number 0.00423587496473018 0.0388093516565979 1.11118347861017 0.459016393442623 4.1 4 1 abnormal intestinal epithelium morphology 0.0107995328654653 0.0793614121206648 1.109529931767 0.458333333333333 4.1 4 1 abnormal adrenal gland morphology 0.0627921827836419 0.321412328751695 1.109529931767 0.458333333333333 4.1 4 1 cleft palate 4.2523360415219e-05 0.00088147382527381 1.10875995957285 0.458015267175573 4.1 4 1 double outlet right ventricle 0.000205740099371949 0.00342219902267186 1.1085872555293 0.457943925233645 4.1 4 1 infertility 0.000205740099371949 0.00342219902267186 1.1085872555293 0.457943925233645 4.1 4 1 abnormal dermal layer morphology 0.0283557126356481 0.166552149188134 1.10664803584033 0.457142857142857 4.1 4 1 abnormal intestinal goblet cell morphology 0.0283557126356481 0.166552149188134 1.10664803584033 0.457142857142857 4.1 4 1 increased exploration in new environment 0.00123679126258213 0.014477733014932 1.10579414075095 0.45679012345679 4.1 4 1 decreased bone mineral content 3.58318006944802e-07 1.23793894760444e-05 1.1056504564811 0.456730769230769 4.1 4 1 atrial septal defect 0.0132722394184477 0.0945979815283341 1.10514443796555 0.456521739130435 4.1 4 1 abnormal craniofacial morphology 0.000303606041243155 0.00479504779423714 1.10463350664887 0.456310679611651 4.1 4 1 absent vitelline blood vessels 0.0063453207417121 0.0551887599475834 1.10422117611261 0.456140350877193 4.1 4 1 abnormal myocardium layer morphology 0.00150657682992135 0.0170345902928607 1.103145985094 0.455696202531646 4.1 4 1 abnormal pulmonary alveolus morphology 0.000368788974208539 0.00563134380670942 1.1025391941231 0.455445544554455 4.1 4 1 teratozoospermia 0.000903950891868192 0.0115311684283186 1.10036026290942 0.454545454545455 4.1 4 1 increased circulating calcium level 0.00776901207317162 0.0627448621169299 1.10036026290942 0.454545454545455 4.1 4 1 abnormal learning/memory/conditioning 0.00776901207317162 0.0627448621169299 1.10036026290942 0.454545454545455 4.1 4 1 decreased macrophage cell number 0.0163191769960749 0.113549518259402 1.10036026290942 0.454545454545455 4.1 4 1 abnormal tail movements 0.0786768808996593 0.357842705637067 1.10036026290942 0.454545454545455 4.1 4 1 abnormal germ layer development 0.0786768808996593 0.357842705637067 1.10036026290942 0.454545454545455 4.1 4 1 increased myocardial infarction size 0.0786768808996593 0.357842705637067 1.10036026290942 0.454545454545455 4.1 4 1 parakeratosis 0.0786768808996593 0.357842705637067 1.10036026290942 0.454545454545455 4.1 4 1 abnormal retinal layer morphology 0.0786768808996593 0.357842705637067 1.10036026290942 0.454545454545455 4.1 4 1 prolonged PR interval 0.0786768808996593 0.357842705637067 1.10036026290942 0.454545454545455 4.1 4 1 abnormal circulating lipid level 0.0786768808996593 0.357842705637067 1.10036026290942 0.454545454545455 4.1 4 1 increased bone volume 0.0786768808996593 0.357842705637067 1.10036026290942 0.454545454545455 4.1 4 1 abnormal stomach epithelium morphology 0.193700425716348 0.633069030194561 1.10036026290942 0.454545454545455 4.1 4 1 abnormal sebaceous gland morphology 0.193700425716348 0.633069030194561 1.10036026290942 0.454545454545455 4.1 4 1 abnormal food preference 0.193700425716348 0.633069030194561 1.10036026290942 0.454545454545455 4.1 4 1 fatigue 0.193700425716348 0.633069030194561 1.10036026290942 0.454545454545455 4.1 4 1 rectal hemorrhage 0.193700425716348 0.633069030194561 1.10036026290942 0.454545454545455 4.1 4 1 abnormal nerve fiber response 0.193700425716348 0.633069030194561 1.10036026290942 0.454545454545455 4.1 4 1 abnormal radial glial cell morphology 0.193700425716348 0.633069030194561 1.10036026290942 0.454545454545455 4.1 4 1 pathological neovascularization 0.193700425716348 0.633069030194561 1.10036026290942 0.454545454545455 4.1 4 1 pharyngeal arch hypoplasia 0.193700425716348 0.633069030194561 1.10036026290942 0.454545454545455 4.1 4 1 increased glycogen level 0.193700425716348 0.633069030194561 1.10036026290942 0.454545454545455 4.1 4 1 aberrant origin of the right subclavian artery 0.193700425716348 0.633069030194561 1.10036026290942 0.454545454545455 4.1 4 1 abnormal extraembryonic ectoderm morphology 0.193700425716348 0.633069030194561 1.10036026290942 0.454545454545455 4.1 4 1 chylous ascites 0.193700425716348 0.633069030194561 1.10036026290942 0.454545454545455 4.1 4 1 cataract 0.000111475361102841 0.00208492451686704 1.10036026290942 0.454545454545455 4.1 4 1 abnormal motor coordination/ balance 0.000447944303970046 0.00657381390044537 1.10036026290942 0.454545454545455 4.1 4 1 abnormal neuron morphology 0.000447944303970046 0.00657381390044537 1.10036026290942 0.454545454545455 4.1 4 1 abnormal ovarian folliculogenesis 0.035099048748558 0.20024973339917 1.10036026290942 0.454545454545455 4.1 4 1 atrioventricular septal defect 0.00951452921127003 0.0727108799171558 1.09620796003052 0.452830188679245 4.1 4 1 decreased body weight 4.93173576014328e-34 3.0669231758391e-31 1.09502733756414 0.452342487883683 4.1 4 1 decreased circulating glucose level 1.13604299281082e-08 5.48719795071244e-07 1.09326116443904 0.451612903225806 4.1 4 1 osteopetrosis 0.0434947486613683 0.238573731632092 1.09326116443904 0.451612903225806 4.1 4 1 abnormal capillary morphology 0.0434947486613683 0.238573731632092 1.09326116443904 0.451612903225806 4.1 4 1 preaxial polydactyly 0.0434947486613683 0.238573731632092 1.09326116443904 0.451612903225806 4.1 4 1 increased bone mineral density 0.00024062555856655 0.00389938812335045 1.09257010175608 0.451327433628319 4.1 4 1 increased circulating free fatty acid level 0.00331805655082641 0.0326231844671174 1.09106144378624 0.450704225352113 4.1 4 1 small ovary 0.000974418517347654 0.0121497045709388 1.09068676609263 0.450549450549451 4.1 4 1 increased thermal nociceptive threshold 0.000974418517347654 0.0121497045709388 1.09068676609263 0.450549450549451 4.1 4 1 perinatal lethality 0.0247117499732389 0.157088139010702 1.08935666028033 0.45 4.1 4 1 anencephaly 0.0988549753888973 0.400817850496955 1.08935666028033 0.45 4.1 4 1 abnormal hair texture 0.0988549753888973 0.400817850496955 1.08935666028033 0.45 4.1 4 1 absent placental labyrinth 0.0988549753888973 0.400817850496955 1.08935666028033 0.45 4.1 4 1 abnormal neuron proliferation 0.0988549753888973 0.400817850496955 1.08935666028033 0.45 4.1 4 1 neonatal lethality, incomplete penetrance 4.72178087748058e-08 1.94139337731123e-06 1.08935666028033 0.45 4.1 4 1 epidermal hyperplasia 0.00683744779962974 0.0586740990932618 1.08935666028033 0.45 4.1 4 1 cochlear ganglion degeneration 0.0083505761959927 0.0661530518711205 1.08518287997274 0.448275862068966 4.1 4 1 glomerulosclerosis 0.0083505761959927 0.0661530518711205 1.08518287997274 0.448275862068966 4.1 4 1 decreased circulating cholesterol level 5.43982544519803e-06 0.000146287197783028 1.08472672911945 0.448087431693989 4.1 4 1 increased circulating HDL cholesterol level 0.000518471613622972 0.00717828370198663 1.08359286842699 0.447619047619048 4.1 4 1 impaired glucose tolerance 1.44644446992346e-07 5.37019495363375e-06 1.08349990404226 0.44758064516129 4.1 4 1 abnormal lung development 0.00174390934912277 0.0193659576158165 1.08223668210856 0.447058823529412 4.1 4 1 decreased body size 9.20687946799169e-21 2.18115358825041e-18 1.07995257883541 0.446115288220551 4.1 4 1 abnormal eye morphology 8.3960642502535e-05 0.0016127575152514 1.0797779846104 0.446043165467626 4.1 4 1 abnormal enzyme/coenzyme activity 3.10106825974572e-05 0.000659308315907477 1.07933427062453 0.445859872611465 4.1 4 1 postnatal lethality 1.88799153635754e-05 0.000436872460157153 1.07914849880514 0.44578313253012 4.1 4 1 increased sensitivity to xenobiotic induced morbidity/mortality 0.000457939164978727 0.00668985769409581 1.07835305765123 0.445454545454545 4.1 4 1 decreased circulating HDL cholesterol level 0.000167262782464451 0.00299328180849152 1.07800919506907 0.4453125 4.1 4 1 decreased heart weight 0.00256926604734252 0.0269097219603369 1.07590781262254 0.444444444444444 4.1 4 1 abnormal metabolism 0.0214598457141064 0.145058060363695 1.07590781262254 0.444444444444444 4.1 4 1 eye inflammation 0.124613649340767 0.479839710116343 1.07590781262254 0.444444444444444 4.1 4 1 abnormal thyroid cartilage morphology 0.124613649340767 0.479839710116343 1.07590781262254 0.444444444444444 4.1 4 1 absent ureter 0.124613649340767 0.479839710116343 1.07590781262254 0.444444444444444 4.1 4 1 long tibia 0.124613649340767 0.479839710116343 1.07590781262254 0.444444444444444 4.1 4 1 increased susceptibility to autoimmune disorder 0.124613649340767 0.479839710116343 1.07590781262254 0.444444444444444 4.1 4 1 jerky movement 0.124613649340767 0.479839710116343 1.07590781262254 0.444444444444444 4.1 4 1 abnormal pregnancy 0.124613649340767 0.479839710116343 1.07590781262254 0.444444444444444 4.1 4 1 abnormal sperm axoneme morphology 0.124613649340767 0.479839710116343 1.07590781262254 0.444444444444444 4.1 4 1 decreased tumor latency 0.124613649340767 0.479839710116343 1.07590781262254 0.444444444444444 4.1 4 1 primary atelectasis 0.124613649340767 0.479839710116343 1.07590781262254 0.444444444444444 4.1 4 1 female infertility 1.07927931020793e-07 4.13031889868036e-06 1.07388542951611 0.443609022556391 4.1 4 1 abnormal myocardial fiber morphology 0.00111454893306015 0.013202097480891 1.07313485434259 0.443298969072165 4.1 4 1 increased circulating cholesterol level 1.47847484632318e-05 0.000362335584259005 1.07285125633669 0.443181818181818 4.1 4 1 abnormal snout morphology 0.0152203083175697 0.107101886675968 1.07073517890801 0.442307692307692 4.1 4 1 decreased birth weight 0.00134896236935333 0.0153924031824148 1.07024513992453 0.442105263157895 4.1 4 1 abnormal left-right axis patterning 0.0263169414759808 0.160843714794846 1.06965253464218 0.441860465116279 4.1 4 1 decreased oxygen consumption 0.0263169414759808 0.160843714794846 1.06965253464218 0.441860465116279 4.1 4 1 abnormal nervous system development 0.0462562958469294 0.252330122629906 1.06799672576503 0.441176470588235 4.1 4 1 delayed bone ossification 0.00458957908755982 0.0418189669608243 1.06514873449632 0.44 4.1 4 1 abnormal interventricular septum morphology 0.0185948215978423 0.126898816802833 1.06514873449632 0.44 4.1 4 1 increased circulating chloride level 0.0185948215978423 0.126898816802833 1.06514873449632 0.44 4.1 4 1 decreased respiratory quotient 0.0185948215978423 0.126898816802833 1.06514873449632 0.44 4.1 4 1 ruffled hair 0.0834249458817606 0.357842705637067 1.06514873449632 0.44 4.1 4 1 abnormal primitive streak morphology 0.0834249458817606 0.357842705637067 1.06514873449632 0.44 4.1 4 1 limb grasping 1.66767560204239e-05 0.00039887914039235 1.06408464984647 0.43956043956044 4.1 4 1 insulin resistance 0.000228164656962341 0.00370953976597271 1.06368158747911 0.439393939393939 4.1 4 1 abnormal mammary gland development 0.0322823327708527 0.187841643900576 1.06278698563934 0.439024390243902 4.1 4 1 abnormal fertility/fecundity 0.00556682733043651 0.0496325554998596 1.06116934943593 0.438356164383562 4.1 4 1 abnormal vertebral body morphology 0.0570834335441269 0.297995888648511 1.05909675305032 0.4375 4.1 4 1 polydipsia 0.0570834335441269 0.297995888648511 1.05909675305032 0.4375 4.1 4 1 increased circulating follicle stimulating hormone level 0.0570834335441269 0.297995888648511 1.05909675305032 0.4375 4.1 4 1 bradykinesia 0.0570834335441269 0.297995888648511 1.05909675305032 0.4375 4.1 4 1 absent mandible 0.157692027102944 0.561573253283569 1.05909675305032 0.4375 4.1 4 1 abnormal mouth morphology 0.157692027102944 0.561573253283569 1.05909675305032 0.4375 4.1 4 1 mixed cellular infiltration to dermis 0.157692027102944 0.561573253283569 1.05909675305032 0.4375 4.1 4 1 poor circulation 0.157692027102944 0.561573253283569 1.05909675305032 0.4375 4.1 4 1 small pancreas 0.157692027102944 0.561573253283569 1.05909675305032 0.4375 4.1 4 1 decreased bone mineral density 4.07565686008026e-07 1.38879403280132e-05 1.05568398155821 0.43609022556391 4.1 4 1 decreased startle reflex 0.000659885988796582 0.00873120424006116 1.05521727776442 0.435897435897436 4.1 4 1 abnormal cornea morphology 0.00484886622382655 0.043543518887251 1.05521727776442 0.435897435897436 4.1 4 1 abnormal heart ventricle morphology 0.00484886622382655 0.043543518887251 1.05521727776442 0.435897435897436 4.1 4 1 acanthosis 0.0396107333894762 0.224958217594342 1.05521727776442 0.435897435897436 4.1 4 1 abnormal circulating hormone level 0.0396107333894762 0.224958217594342 1.05521727776442 0.435897435897436 4.1 4 1 abnormal circulating insulin level 0.103976485828488 0.419532049470177 1.05251851234814 0.434782608695652 4.1 4 1 failure of embryo implantation 0.103976485828488 0.419532049470177 1.05251851234814 0.434782608695652 4.1 4 1 conjunctivitis 0.103976485828488 0.419532049470177 1.05251851234814 0.434782608695652 4.1 4 1 abnormal nasal cavity morphology 0.103976485828488 0.419532049470177 1.05251851234814 0.434782608695652 4.1 4 1 abnormal sacral vertebrae morphology 0.103976485828488 0.419532049470177 1.05251851234814 0.434782608695652 4.1 4 1 abnormal palatal shelf fusion at midline 0.103976485828488 0.419532049470177 1.05251851234814 0.434782608695652 4.1 4 1 increased insulin sensitivity 0.000222887998762676 0.00363563211096496 1.04957440462129 0.433566433566434 4.1 4 1 malocclusion 0.0486154752982903 0.26461924464879 1.04682922309221 0.432432432432432 4.1 4 1 perinatal lethality, complete penetrance 9.71972754471779e-06 0.000247640814182536 1.04560055029515 0.431924882629108 4.1 4 1 decreased sensitivity to induced morbidity/mortality 0.0339152424807094 0.195287420534177 1.04534224976395 0.431818181818182 4.1 4 1 reduced fertility 0.00032129690749134 0.00502657897726232 1.04494643671974 0.431654676258993 4.1 4 1 kinked tail 0.00191339286649272 0.0207841255694351 1.04426346519247 0.431372549019608 4.1 4 1 impaired balance 0.00191339286649272 0.0207841255694351 1.04426346519247 0.431372549019608 4.1 4 1 small lung 0.0238593285053827 0.15659651624575 1.04426346519247 0.431372549019608 4.1 4 1 cochlear inner hair cell degeneration 0.0238593285053827 0.15659651624575 1.04426346519247 0.431372549019608 4.1 4 1 abnormal renal glomerulus morphology 0.0013852711924226 0.0156986883423746 1.04382799252141 0.431192660550459 4.1 4 1 hunched posture 0.00615668908362571 0.0537360143702419 1.04186009703322 0.430379746835443 4.1 4 1 hypoglycemia 0.00318941932895719 0.0321853167577323 1.04120110898956 0.43010752688172 4.1 4 1 decreased grip strength 1.0671389246745e-05 0.000264130156729137 1.03906165465602 0.429223744292237 4.1 4 1 abnormal glucose homeostasis 6.08169444638232e-05 0.00122495667492923 1.03748253360031 0.428571428571429 4.1 4 1 organ of Corti degeneration 0.0290466552732563 0.170208610111248 1.03748253360031 0.428571428571429 4.1 4 1 skin edema 0.0414369815752393 0.232761928593362 1.03748253360031 0.428571428571429 4.1 4 1 abnormal embryonic/fetal subventricular zone morphology 0.129830189896352 0.498383637912307 1.03748253360031 0.428571428571429 4.1 4 1 abnormal tumor vascularization 0.129830189896352 0.498383637912307 1.03748253360031 0.428571428571429 4.1 4 1 decreased circulating thyroxine level 0.0596817332553905 0.309288148901633 1.03748253360031 0.428571428571429 4.1 4 1 decreased bone volume 0.0596817332553905 0.309288148901633 1.03748253360031 0.428571428571429 4.1 4 1 decreased bone mineralization 0.0596817332553905 0.309288148901633 1.03748253360031 0.428571428571429 4.1 4 1 abnormal ovulation 0.0871266270920698 0.363942040120107 1.03748253360031 0.428571428571429 4.1 4 1 straub tail 0.0871266270920698 0.363942040120107 1.03748253360031 0.428571428571429 4.1 4 1 abnormal renal tubule epithelium morphology 0.0871266270920698 0.363942040120107 1.03748253360031 0.428571428571429 4.1 4 1 abnormal blood flow velocity 0.200478819515238 0.633069030194561 1.03748253360031 0.428571428571429 4.1 4 1 abnormal antigen presentation 0.200478819515238 0.633069030194561 1.03748253360031 0.428571428571429 4.1 4 1 decreased CNS synapse formation 0.200478819515238 0.633069030194561 1.03748253360031 0.428571428571429 4.1 4 1 abnormal iris pigmentation 0.200478819515238 0.633069030194561 1.03748253360031 0.428571428571429 4.1 4 1 reduced male fertility 9.75630142307077e-06 0.000247640814182536 1.03443559517564 0.427312775330396 4.1 4 1 retinal degeneration 0.00333251590374389 0.0327007231185915 1.03388016369198 0.427083333333333 4.1 4 1 hydroencephaly 0.00151310507017087 0.0170696093517009 1.03146814210118 0.426086956521739 4.1 4 1 abnormal maxilla morphology 0.0248889656888531 0.157088139010702 1.03107832042994 0.425925925925926 4.1 4 1 ataxia 3.54158563537145e-05 0.000740310442687941 1.0306344640716 0.425742574257426 4.1 4 1 impaired ovarian folliculogenesis 0.0506230254797387 0.274047390382699 1.02883684582031 0.425 4.1 4 1 abnormal locomotor coordination 0.0732824539198095 0.356035359620168 1.02700291204879 0.424242424242424 4.1 4 1 cardiac fibrosis 0.00669154862293466 0.0579973073155051 1.02527685673443 0.423529411764706 4.1 4 1 ventricular hypoplasia 0.107764006277502 0.431316115229745 1.02418147547723 0.423076923076923 4.1 4 1 increased susceptibility to otitis media 0.107764006277502 0.431316115229745 1.02418147547723 0.423076923076923 4.1 4 1 increased urine protein level 0.00932727299363242 0.0714995117770744 1.02418147547723 0.423076923076923 4.1 4 1 decreased insulin secretion 0.00578058066386667 0.0510566440242733 1.02211242199142 0.422222222222222 4.1 4 1 abnormal lens morphology 0.00118614165913991 0.0139835420716139 1.02127186901281 0.421875 4.1 4 1 decreased eosinophil cell number 0.0183064666957638 0.125447206351825 1.02127186901281 0.421875 4.1 4 1 abnormal bone mineralization 0.00163462538146627 0.0182747444332465 1.02033406197055 0.421487603305785 4.1 4 1 alopecia 0.00499431411044441 0.0446883321932751 1.01928108564241 0.421052631578947 4.1 4 1 thin dermal layer 0.162444661895754 0.574407517762567 1.01928108564241 0.421052631578947 4.1 4 1 abnormal neural crest cell migration 0.162444661895754 0.574407517762567 1.01928108564241 0.421052631578947 4.1 4 1 abnormal digestive system development 0.162444661895754 0.574407517762567 1.01928108564241 0.421052631578947 4.1 4 1 decreased liver regeneration 0.162444661895754 0.574407517762567 1.01928108564241 0.421052631578947 4.1 4 1 increased liver cholesterol level 0.162444661895754 0.574407517762567 1.01928108564241 0.421052631578947 4.1 4 1 increased circulating triglyceride level 0.000649926775398214 0.00864541633049763 1.01840239505134 0.420689655172414 4.1 4 1 increased blood urea nitrogen level 0.000649926775398214 0.00864541633049763 1.01840239505134 0.420689655172414 4.1 4 1 hyperglycemia 0.00693820414330474 0.0588793249735871 1.01783324319121 0.420454545454545 4.1 4 1 abnormal object recognition memory 0.0899973028547588 0.369724675229088 1.01517108126482 0.419354838709677 4.1 4 1 decreased neuronal precursor cell number 0.0899973028547588 0.369724675229088 1.01517108126482 0.419354838709677 4.1 4 1 abnormal podocyte morphology 0.0899973028547588 0.369724675229088 1.01517108126482 0.419354838709677 4.1 4 1 small cranium 0.0899973028547588 0.369724675229088 1.01517108126482 0.419354838709677 4.1 4 1 polydactyly 0.00516652895896379 0.0461462864826658 1.01278056851459 0.418367346938776 4.1 4 1 postnatal lethality, incomplete penetrance 1.08098291689622e-10 6.72236251444838e-09 1.01008422725523 0.417253521126761 4.1 4 1 cochlear outer hair cell degeneration 0.0162238135685128 0.113044079136346 1.00866357433364 0.416666666666667 4.1 4 1 abnormal eating behavior 0.026644626252272 0.162646644914176 1.00866357433364 0.416666666666667 4.1 4 1 abnormal osteoclast morphology 0.0443783950106076 0.243152549755256 1.00866357433364 0.416666666666667 4.1 4 1 abnormal uterus morphology 0.0755195157765995 0.357842705637067 1.00866357433364 0.416666666666667 4.1 4 1 impaired wound healing 0.0755195157765995 0.357842705637067 1.00866357433364 0.416666666666667 4.1 4 1 curly vibrissae 0.133393845146236 0.50970382457951 1.00866357433364 0.416666666666667 4.1 4 1 hypopigmentation 0.133393845146236 0.50970382457951 1.00866357433364 0.416666666666667 4.1 4 1 increased body temperature 0.133393845146236 0.50970382457951 1.00866357433364 0.416666666666667 4.1 4 1 abnormal lung saccule morphology 0.133393845146236 0.50970382457951 1.00866357433364 0.416666666666667 4.1 4 1 abnormal mineral level 0.25632188711582 0.67455534405292 1.00866357433364 0.416666666666667 4.1 4 1 amyloidosis 0.25632188711582 0.67455534405292 1.00866357433364 0.416666666666667 4.1 4 1 mesocardia 0.25632188711582 0.67455534405292 1.00866357433364 0.416666666666667 4.1 4 1 abnormal mating frequency 0.25632188711582 0.67455534405292 1.00866357433364 0.416666666666667 4.1 4 1 abnormal respiratory function 0.25632188711582 0.67455534405292 1.00866357433364 0.416666666666667 4.1 4 1 small thyroid gland 0.25632188711582 0.67455534405292 1.00866357433364 0.416666666666667 4.1 4 1 abnormal gastrocnemius morphology 0.25632188711582 0.67455534405292 1.00866357433364 0.416666666666667 4.1 4 1 abnormal aorta elastic fiber morphology 0.25632188711582 0.67455534405292 1.00866357433364 0.416666666666667 4.1 4 1 delayed somite formation 0.25632188711582 0.67455534405292 1.00866357433364 0.416666666666667 4.1 4 1 abnormal rostral-caudal body axis extension 0.25632188711582 0.67455534405292 1.00866357433364 0.416666666666667 4.1 4 1 vestibular saccular macula degeneration 0.25632188711582 0.67455534405292 1.00866357433364 0.416666666666667 4.1 4 1 stria vascularis degeneration 0.25632188711582 0.67455534405292 1.00866357433364 0.416666666666667 4.1 4 1 abnormal cochlear outer hair cell physiology 0.25632188711582 0.67455534405292 1.00866357433364 0.416666666666667 4.1 4 1 hematuria 0.25632188711582 0.67455534405292 1.00866357433364 0.416666666666667 4.1 4 1 increased skeletal muscle glycogen level 0.25632188711582 0.67455534405292 1.00866357433364 0.416666666666667 4.1 4 1 decreased monocyte cell number 0.0227729229959728 0.150259007831518 1.00555999410492 0.415384615384615 4.1 4 1 scaly skin 0.0636143494818662 0.321412328751695 1.00374326421494 0.414634146341463 4.1 4 1 liver fibrosis 0.0636143494818662 0.321412328751695 1.00374326421494 0.414634146341463 4.1 4 1 no abnormal phenotype detected 5.97433947682431e-29 2.70203080883645e-26 1.00319876880122 0.414409221902017 4.1 4 1 domed cranium 0.0194856512909625 0.132433217448823 1.0028997824803 0.414285714285714 4.1 4 1 enlarged epididymis 0.110534755980642 0.441340618783062 1.00170727382099 0.413793103448276 4.1 4 1 abnormal cardiovascular system physiology 0.0018563937621962 0.020536007158511 1.00107963768451 0.413533834586466 4.1 4 1 skin lesions 0.0273849534393198 0.164648278078482 0.999057254578077 0.412698412698413 4.1 4 1 abnormal posture 0.0143084904771681 0.101258520802149 0.9985769385903 0.4125 4.1 4 1 abnormal lung morphology 0.00351834139140935 0.0338563799270049 0.996796944047358 0.411764705882353 4.1 4 1 distended abdomen 0.0455443516732603 0.249266391171034 0.996796944047358 0.411764705882353 4.1 4 1 abnormal bone marrow cavity morphology 0.203712659479702 0.633069030194561 0.996796944047358 0.411764705882353 4.1 4 1 abnormal involuntary movement 0.203712659479702 0.633069030194561 0.996796944047358 0.411764705882353 4.1 4 1 abnormal testis development 0.203712659479702 0.633069030194561 0.996796944047358 0.411764705882353 4.1 4 1 increased circulating magnesium level 0.203712659479702 0.633069030194561 0.996796944047358 0.411764705882353 4.1 4 1 abnormal survival 0.203712659479702 0.633069030194561 0.996796944047358 0.411764705882353 4.1 4 1 delayed heart development 0.203712659479702 0.633069030194561 0.996796944047358 0.411764705882353 4.1 4 1 abnormal ductus venosus valve morphology 0.203712659479702 0.633069030194561 0.996796944047358 0.411764705882353 4.1 4 1 abnormal gametogenesis 0.065067526730857 0.322421260444237 0.990324236618479 0.409090909090909 4.1 4 1 intracerebral hemorrhage 0.165244019201754 0.581300387827394 0.990324236618479 0.409090909090909 4.1 4 1 aphakia 0.165244019201754 0.581300387827394 0.990324236618479 0.409090909090909 4.1 4 1 abnormal female reproductive system physiology 0.165244019201754 0.581300387827394 0.990324236618479 0.409090909090909 4.1 4 1 abnormal limb posture 0.165244019201754 0.581300387827394 0.990324236618479 0.409090909090909 4.1 4 1 decreased circulating estradiol level 0.165244019201754 0.581300387827394 0.990324236618479 0.409090909090909 4.1 4 1 lethargy 0.0107951356578496 0.0793614121206648 0.989141053540082 0.408602150537634 4.1 4 1 impaired coordination 2.80156295936533e-06 7.96444327019573e-05 0.986507958250007 0.407514450867052 4.1 4 1 abnormal rib morphology 0.00274775834789113 0.0287186928167192 0.986248828237333 0.407407407407407 4.1 4 1 abnormal axon morphology 0.00685572422954798 0.0586740990932618 0.986248828237333 0.407407407407407 4.1 4 1 impaired limb coordination 0.0465364407878016 0.253580277020058 0.986248828237333 0.407407407407407 4.1 4 1 abnormal heart valve morphology 0.135757013170204 0.515871950046149 0.986248828237333 0.407407407407407 4.1 4 1 rectal prolapse 0.135757013170204 0.515871950046149 0.986248828237333 0.407407407407407 4.1 4 1 abnormal type II pneumocyte morphology 0.135757013170204 0.515871950046149 0.986248828237333 0.407407407407407 4.1 4 1 abnormal skin appearance 0.135757013170204 0.515871950046149 0.986248828237333 0.407407407407407 4.1 4 1 neonatal lethality 0.112517318698876 0.448177470397843 0.983446984975295 0.40625 4.1 4 1 abnormal heart atrium morphology 0.112517318698876 0.448177470397843 0.983446984975295 0.40625 4.1 4 1 abnormal depression-related behavior 0.112517318698876 0.448177470397843 0.983446984975295 0.40625 4.1 4 1 hyperkeratosis 0.0286240016599462 0.167929726719614 0.982350611524932 0.405797101449275 4.1 4 1 increased white adipose tissue amount 0.093863179739083 0.383390245650195 0.981402396648943 0.405405405405405 4.1 4 1 abnormal pancreatic beta cell physiology 0.093863179739083 0.383390245650195 0.981402396648943 0.405405405405405 4.1 4 1 abnormal calcium ion homeostasis 0.093863179739083 0.383390245650195 0.981402396648943 0.405405405405405 4.1 4 1 hepatic necrosis 0.0662421560120939 0.327915150408126 0.978618276374762 0.404255319148936 4.1 4 1 absent corpus luteum 0.0559425637904571 0.293271079934167 0.977627772046447 0.403846153846154 4.1 4 1 eyelids open at birth 0.0559425637904571 0.293271079934167 0.977627772046447 0.403846153846154 4.1 4 1 increased total body fat amount 0.00392101015481879 0.0362584117476272 0.975543277862979 0.402985074626866 4.1 4 1 rib fusion 0.0341978425944704 0.195893388234178 0.975543277862979 0.402985074626866 4.1 4 1 abnormal neuron differentiation 0.00844075238653504 0.0667611178426261 0.972639875250292 0.401785714285714 4.1 4 1 thick epidermis 0.0347162352392687 0.198293077285145 0.96831703136029 0.4 4.1 4 1 decreased circulating phosphate level 0.0950829812910803 0.387590794102759 0.96831703136029 0.4 4.1 4 1 abnormal female reproductive system morphology 0.0950829812910803 0.387590794102759 0.96831703136029 0.4 4.1 4 1 thick pulmonary interalveolar septum 0.113880118781116 0.452157694282562 0.96831703136029 0.4 4.1 4 1 abnormal artery morphology 0.113880118781116 0.452157694282562 0.96831703136029 0.4 4.1 4 1 decreased triglyceride level 0.113880118781116 0.452157694282562 0.96831703136029 0.4 4.1 4 1 waved hair 0.204837786233658 0.633069030194561 0.96831703136029 0.4 4.1 4 1 abnormal hyoid bone morphology 0.204837786233658 0.633069030194561 0.96831703136029 0.4 4.1 4 1 abnormal response to tactile stimuli 0.204837786233658 0.633069030194561 0.96831703136029 0.4 4.1 4 1 abnormal induced retinal neovascularization 0.204837786233658 0.633069030194561 0.96831703136029 0.4 4.1 4 1 abnormal nervous system physiology 0.00857485011464186 0.0670752819502252 0.96831703136029 0.4 4.1 4 1 abnormal skeleton morphology 0.00857485011464186 0.0670752819502252 0.96831703136029 0.4 4.1 4 1 abnormal heart tube morphology 0.13722710547347 0.515871950046149 0.96831703136029 0.4 4.1 4 1 abnormal nest building behavior 0.166706444655886 0.583406784382307 0.96831703136029 0.4 4.1 4 1 abnormal keratinocyte physiology 0.166706444655886 0.583406784382307 0.96831703136029 0.4 4.1 4 1 abnormal cochlear outer hair cell morphology 0.166706444655886 0.583406784382307 0.96831703136029 0.4 4.1 4 1 hyperpigmentation 0.256097057033773 0.67455534405292 0.96831703136029 0.4 4.1 4 1 audiogenic seizures 0.256097057033773 0.67455534405292 0.96831703136029 0.4 4.1 4 1 increased airway responsiveness 0.256097057033773 0.67455534405292 0.96831703136029 0.4 4.1 4 1 abnormal bronchus morphology 0.256097057033773 0.67455534405292 0.96831703136029 0.4 4.1 4 1 abnormal olfactory nerve morphology 0.256097057033773 0.67455534405292 0.96831703136029 0.4 4.1 4 1 absent chorion 0.256097057033773 0.67455534405292 0.96831703136029 0.4 4.1 4 1 decreased litter size 8.34718160170771e-05 0.0016127575152514 0.964871063277158 0.398576512455516 4.1 4 1 short snout 0.0117870193148328 0.0856064541478735 0.96383408214103 0.398148148148148 4.1 4 1 cardiac hypertrophy 0.0160222916571697 0.111796495083337 0.963376638343146 0.397959183673469 4.1 4 1 abnormal pancreatic islet morphology 0.0679030250061549 0.335802733007575 0.959181965026703 0.39622641509434 4.1 4 1 abnormal kidney physiology 0.0805666890820332 0.357842705637067 0.958230395616954 0.395833333333333 4.1 4 1 curly tail 0.0805666890820332 0.357842705637067 0.958230395616954 0.395833333333333 4.1 4 1 abnormal retina morphology 0.000863949665065195 0.0110492277215921 0.95678944765362 0.395238095238095 4.1 4 1 abnormal frontal bone morphology 0.114749723206677 0.453037453675569 0.95557601778976 0.394736842105263 4.1 4 1 increased grooming behavior 0.114749723206677 0.453037453675569 0.95557601778976 0.394736842105263 4.1 4 1 abnormal reproductive system physiology 0.114749723206677 0.453037453675569 0.95557601778976 0.394736842105263 4.1 4 1 atelectasis 0.0417368246382008 0.232761928593362 0.954678763312962 0.394366197183099 4.1 4 1 abnormal kidney morphology 0.00239434910065532 0.0256169608080865 0.954483930912286 0.394285714285714 4.1 4 1 belly spot 0.138019980805268 0.516516345886487 0.953645561188165 0.393939393939394 4.1 4 1 increased startle reflex 0.026121676438268 0.160043522512788 0.951997081393544 0.393258426966292 4.1 4 1 abnormal circulating cholesterol level 0.167223733573703 0.583406784382307 0.951025655800285 0.392857142857143 4.1 4 1 shortened head 0.167223733573703 0.583406784382307 0.951025655800285 0.392857142857143 4.1 4 1 reddish skin 0.167223733573703 0.583406784382307 0.951025655800285 0.392857142857143 4.1 4 1 hypoxia 0.167223733573703 0.583406784382307 0.951025655800285 0.392857142857143 4.1 4 1 increased triglyceride level 0.167223733573703 0.583406784382307 0.951025655800285 0.392857142857143 4.1 4 1 abnormal gluconeogenesis 0.0811327763520326 0.357842705637067 0.949330422902246 0.392156862745098 4.1 4 1 abnormal sternum morphology 0.0494786596809736 0.269023313565949 0.947266661113328 0.391304347826087 4.1 4 1 delayed wound healing 0.0964899867568709 0.392829528736033 0.947266661113328 0.391304347826087 4.1 4 1 abnormal pulmonary artery morphology 0.204630290655997 0.633069030194561 0.947266661113328 0.391304347826087 4.1 4 1 abnormal postnatal growth 0.204630290655997 0.633069030194561 0.947266661113328 0.391304347826087 4.1 4 1 abnormal osteoblast physiology 0.0814999422360155 0.357842705637067 0.941419336044727 0.388888888888889 4.1 4 1 abnormal epidermis stratum granulosum morphology 0.138291411602171 0.516516345886487 0.941419336044727 0.388888888888889 4.1 4 1 narrow eye opening 0.138291411602171 0.516516345886487 0.941419336044727 0.388888888888889 4.1 4 1 lowered ear position 0.254048393204479 0.67455534405292 0.941419336044727 0.388888888888889 4.1 4 1 abnormal mitral valve morphology 0.254048393204479 0.67455534405292 0.941419336044727 0.388888888888889 4.1 4 1 abnormal retinal rod cell morphology 0.254048393204479 0.67455534405292 0.941419336044727 0.388888888888889 4.1 4 1 thick dermal layer 0.254048393204479 0.67455534405292 0.941419336044727 0.388888888888889 4.1 4 1 abnormal white adipose tissue morphology 0.254048393204479 0.67455534405292 0.941419336044727 0.388888888888889 4.1 4 1 absent allantois 0.254048393204479 0.67455534405292 0.941419336044727 0.388888888888889 4.1 4 1 increased circulating glycerol level 0.254048393204479 0.67455534405292 0.941419336044727 0.388888888888889 4.1 4 1 abnormal glycogen homeostasis 0.254048393204479 0.67455534405292 0.941419336044727 0.388888888888889 4.1 4 1 increased circulating LDL cholesterol level 0.0967893200396914 0.393725974813953 0.938674673257424 0.387755102040816 4.1 4 1 increased or absent threshold for auditory brainstem response 0.000306292220656973 0.00482216391698874 0.938161829691631 0.387543252595156 4.1 4 1 increased circulating insulin level 0.0060276807090447 0.0527024807161641 0.938057124130281 0.3875 4.1 4 1 embryonic lethality, incomplete penetrance 0.115374794650237 0.453037453675569 0.935306223473008 0.386363636363636 4.1 4 1 abnormal facial morphology 0.0816966252836195 0.357842705637067 0.93434099517221 0.385964912280702 4.1 4 1 microphthalmia 0.00813793537080788 0.0646744863734332 0.933508249187208 0.38562091503268 4.1 4 1 abnormal gait 0.000272741623437886 0.00434900505321629 0.932279342490895 0.385113268608414 4.1 4 1 abnormal nasal bone morphology 0.203545468642375 0.633069030194561 0.931074068615664 0.384615384615385 4.1 4 1 absent teeth 0.322799022359421 0.708938429602875 0.931074068615664 0.384615384615385 4.1 4 1 absent myocardial trabeculae 0.322799022359421 0.708938429602875 0.931074068615664 0.384615384615385 4.1 4 1 uterus hypoplasia 0.322799022359421 0.708938429602875 0.931074068615664 0.384615384615385 4.1 4 1 pup cannibalization 0.322799022359421 0.708938429602875 0.931074068615664 0.384615384615385 4.1 4 1 anal atresia 0.322799022359421 0.708938429602875 0.931074068615664 0.384615384615385 4.1 4 1 decreased endocochlear potential 0.322799022359421 0.708938429602875 0.931074068615664 0.384615384615385 4.1 4 1 abnormal vertebral arch development 0.322799022359421 0.708938429602875 0.931074068615664 0.384615384615385 4.1 4 1 abnormal heart looping 0.13815642585676 0.516516345886487 0.931074068615664 0.384615384615385 4.1 4 1 abnormal response to injury 0.13815642585676 0.516516345886487 0.931074068615664 0.384615384615385 4.1 4 1 respiratory failure 0.00946905476708826 0.0724746884096371 0.929840857928756 0.384105960264901 4.1 4 1 hyperactivity 0.000105432432391963 0.00199439677243353 0.926556728121033 0.382749326145553 4.1 4 1 thin skin 0.166384257521828 0.583406784382307 0.925597162329689 0.382352941176471 4.1 4 1 abnormal endoderm development 0.166384257521828 0.583406784382307 0.925597162329689 0.382352941176471 4.1 4 1 abnormal muscle physiology 0.0428299291058062 0.237546150837666 0.9247971647823 0.382022471910112 4.1 4 1 decreased inflammatory response 0.0501498519967319 0.272077986568965 0.92220669653361 0.380952380952381 4.1 4 1 abnormal muscle morphology 0.137701641643195 0.516251444743704 0.92220669653361 0.380952380952381 4.1 4 1 spina bifida 0.137701641643195 0.516251444743704 0.92220669653361 0.380952380952381 4.1 4 1 abnormal associative learning 0.250996307056616 0.67455534405292 0.92220669653361 0.380952380952381 4.1 4 1 increased vasoconstriction 0.250996307056616 0.67455534405292 0.92220669653361 0.380952380952381 4.1 4 1 increased bone ossification 0.250996307056616 0.67455534405292 0.92220669653361 0.380952380952381 4.1 4 1 increased sensitivity to induced morbidity/mortality 0.00617749029465755 0.0538231422345382 0.920953698304624 0.380434782608696 4.1 4 1 increased body length 0.114939093734362 0.453037453675569 0.919901179792276 0.38 4.1 4 1 abnormal outer ear morphology 0.20186699765835 0.633069030194561 0.918231667669241 0.379310344827586 4.1 4 1 decreased bone strength 0.20186699765835 0.633069030194561 0.918231667669241 0.379310344827586 4.1 4 1 abnormal skin morphology 0.0814855236968911 0.357842705637067 0.916966885757851 0.378787878787879 4.1 4 1 abnormal intestine morphology 0.0690421470096134 0.340758612473042 0.91597557020568 0.378378378378378 4.1 4 1 abnormal vocalization 0.165334683171008 0.581300387827394 0.91597557020568 0.378378378378378 4.1 4 1 abnormal hair follicle development 0.165334683171008 0.581300387827394 0.91597557020568 0.378378378378378 4.1 4 1 increased circulating corticosterone level 0.13699338636049 0.515871950046149 0.914521640729163 0.377777777777778 4.1 4 1 cardiomyopathy 0.13699338636049 0.515871950046149 0.914521640729163 0.377777777777778 4.1 4 1 neonatal lethality, complete penetrance 8.04877754986811e-05 0.0015703007180625 0.907797216900272 0.375 4.1 4 1 pancreatic islet hyperplasia 0.199779935973976 0.633069030194561 0.907797216900272 0.375 4.1 4 1 ocular hypertelorism 0.247372157961853 0.67455534405292 0.907797216900272 0.375 4.1 4 1 abnormal nursing 0.247372157961853 0.67455534405292 0.907797216900272 0.375 4.1 4 1 abnormal startle reflex 0.247372157961853 0.67455534405292 0.907797216900272 0.375 4.1 4 1 abnormal vasodilation 0.247372157961853 0.67455534405292 0.907797216900272 0.375 4.1 4 1 blindness 0.247372157961853 0.67455534405292 0.907797216900272 0.375 4.1 4 1 failure of tooth eruption 0.31514007499227 0.708938429602875 0.907797216900272 0.375 4.1 4 1 vasculature congestion 0.31514007499227 0.708938429602875 0.907797216900272 0.375 4.1 4 1 disorganized retinal layers 0.31514007499227 0.708938429602875 0.907797216900272 0.375 4.1 4 1 abnormal extraembryonic endoderm formation 0.31514007499227 0.708938429602875 0.907797216900272 0.375 4.1 4 1 abnormal epicardium morphology 0.31514007499227 0.708938429602875 0.907797216900272 0.375 4.1 4 1 small epididymis 0.31514007499227 0.708938429602875 0.907797216900272 0.375 4.1 4 1 abnormal wound healing 0.31514007499227 0.708938429602875 0.907797216900272 0.375 4.1 4 1 abnormal Langerhans cell physiology 0.31514007499227 0.708938429602875 0.907797216900272 0.375 4.1 4 1 kidney degeneration 0.31514007499227 0.708938429602875 0.907797216900272 0.375 4.1 4 1 increased heart left ventricle size 0.31514007499227 0.708938429602875 0.907797216900272 0.375 4.1 4 1 hypoactivity 0.00036543737458862 0.00561126832894563 0.905389266722818 0.374005305039788 4.1 4 1 short tail 0.0682163112638647 0.3370170293324 0.904151444944849 0.373493975903614 4.1 4 1 maternal effect 0.0951252984119535 0.387590794102759 0.903280812836092 0.373134328358209 4.1 4 1 increased hemoglobin content 0.113016838299799 0.449807016433199 0.902668419064678 0.372881355932203 4.1 4 1 abnormal dendritic spine morphology 0.13501159468012 0.515489396418722 0.901863901757133 0.372549019607843 4.1 4 1 kidney failure 0.162450528139082 0.574407517762567 0.900760029172363 0.372093023255814 4.1 4 1 abnormal motor capabilities/coordination/movement 0.0306512856052586 0.179189360618286 0.898627548042694 0.371212121212121 4.1 4 1 increased body weight 0.00689545359576411 0.0588419925195994 0.896990107175269 0.370535714285714 4.1 4 1 abnormal palate morphology 0.243421030684829 0.67455534405292 0.896589843852121 0.37037037037037 4.1 4 1 abnormal inner ear morphology 0.160736758541921 0.570781851353361 0.89464073549592 0.369565217391304 4.1 4 1 decreased exploration in new environment 0.0787834855521874 0.357842705637067 0.893387737266935 0.369047619047619 4.1 4 1 increased food intake 0.0787834855521874 0.357842705637067 0.893387737266935 0.369047619047619 4.1 4 1 abnormal axial skeleton morphology 0.0929905413648949 0.380763739333623 0.89187094993711 0.368421052631579 4.1 4 1 persistence of hyaloid vascular system 0.194842576483534 0.633069030194561 0.89187094993711 0.368421052631579 4.1 4 1 abnormal compact bone morphology 0.194842576483534 0.633069030194561 0.89187094993711 0.368421052631579 4.1 4 1 irregular coat pigmentation 0.307483903134568 0.7030020303743 0.89187094993711 0.368421052631579 4.1 4 1 short vibrissae 0.307483903134568 0.7030020303743 0.89187094993711 0.368421052631579 4.1 4 1 stereotypic behavior 0.307483903134568 0.7030020303743 0.89187094993711 0.368421052631579 4.1 4 1 abnormal metatarsal bone morphology 0.307483903134568 0.7030020303743 0.89187094993711 0.368421052631579 4.1 4 1 abnormal response to novelty 0.307483903134568 0.7030020303743 0.89187094993711 0.368421052631579 4.1 4 1 abnormal optic vesicle formation 0.307483903134568 0.7030020303743 0.89187094993711 0.368421052631579 4.1 4 1 increased circulating VLDL cholesterol level 0.307483903134568 0.7030020303743 0.89187094993711 0.368421052631579 4.1 4 1 decreased eye pigmentation 0.307483903134568 0.7030020303743 0.89187094993711 0.368421052631579 4.1 4 1 decreased fertilization frequency 0.307483903134568 0.7030020303743 0.89187094993711 0.368421052631579 4.1 4 1 decreased susceptibility to weight gain 0.307483903134568 0.7030020303743 0.89187094993711 0.368421052631579 4.1 4 1 abnormal craniofacial bone morphology 0.13250684378432 0.507874844242674 0.89187094993711 0.368421052631579 4.1 4 1 absent kidney 0.158898986057165 0.564658896881712 0.889270743085981 0.36734693877551 4.1 4 1 increased fluid intake 0.158898986057165 0.564658896881712 0.889270743085981 0.36734693877551 4.1 4 1 abnormal vertebrae morphology 0.0558117498087139 0.293203226291818 0.888364248954395 0.36697247706422 4.1 4 1 abnormal hair cycle 0.239290093133808 0.67455534405292 0.8876239454136 0.366666666666667 4.1 4 1 abnormal skeletal muscle fiber morphology 0.109088804442745 0.435917110122618 0.886487423076322 0.366197183098592 4.1 4 1 increased tumor growth/size 0.192141408142624 0.633069030194561 0.885655821366119 0.365853658536585 4.1 4 1 abnormal cholesterol homeostasis 0.192141408142624 0.633069030194561 0.885655821366119 0.365853658536585 4.1 4 1 lethality at weaning, incomplete penetrance 0.192141408142624 0.633069030194561 0.885655821366119 0.365853658536585 4.1 4 1 kidney cysts 0.107962550402992 0.431763414995889 0.883262156984049 0.364864864864865 4.1 4 1 abnormal circadian rhythm 0.189350947275565 0.633069030194561 0.880288210327537 0.363636363636364 4.1 4 1 omphalocele 0.189350947275565 0.633069030194561 0.880288210327537 0.363636363636364 4.1 4 1 renal interstitial fibrosis 0.189350947275565 0.633069030194561 0.880288210327537 0.363636363636364 4.1 4 1 abnormal long bone epiphysis morphology 0.299997614402252 0.690008382640409 0.880288210327537 0.363636363636364 4.1 4 1 abnormal enterocyte morphology 0.299997614402252 0.690008382640409 0.880288210327537 0.363636363636364 4.1 4 1 abnormal facial nerve morphology 0.299997614402252 0.690008382640409 0.880288210327537 0.363636363636364 4.1 4 1 increased body size 0.299997614402252 0.690008382640409 0.880288210327537 0.363636363636364 4.1 4 1 cleft upper lip 0.299997614402252 0.690008382640409 0.880288210327537 0.363636363636364 4.1 4 1 abnormal aorta morphology 0.235071338927523 0.67455534405292 0.880288210327537 0.363636363636364 4.1 4 1 abnormal epidermis stratum basale morphology 0.235071338927523 0.67455534405292 0.880288210327537 0.363636363636364 4.1 4 1 decreased systemic arterial blood pressure 0.235071338927523 0.67455534405292 0.880288210327537 0.363636363636364 4.1 4 1 diarrhea 0.235071338927523 0.67455534405292 0.880288210327537 0.363636363636364 4.1 4 1 postnatal lethality, complete penetrance 0.0016011372558704 0.017940670828728 0.878007670922543 0.362694300518135 4.1 4 1 abnormal retinal pigment epithelium morphology 0.105604003008374 0.425061353176072 0.877537309670263 0.3625 4.1 4 1 abnormal neuromuscular synapse morphology 0.12505259130229 0.481157495536652 0.874175097755818 0.361111111111111 4.1 4 1 heart right ventricle hypertrophy 0.230823962786009 0.67455534405292 0.874175097755818 0.361111111111111 4.1 4 1 abnormal limb bone morphology 0.230823962786009 0.67455534405292 0.874175097755818 0.361111111111111 4.1 4 1 renal hypoplasia 0.230823962786009 0.67455534405292 0.874175097755818 0.361111111111111 4.1 4 1 abnormal thyroid gland morphology 0.292746621696459 0.675203728762117 0.871485328224261 0.36 4.1 4 1 cyanosis 0.0261006532969412 0.160043522512788 0.869972332862761 0.359375 4.1 4 1 absent gastric milk in neonates 0.121850004836224 0.472857858081291 0.869002464041286 0.358974358974359 4.1 4 1 small lens 0.226586820834527 0.67455534405292 0.869002464041286 0.358974358974359 4.1 4 1 abnormal lens fiber morphology 0.226586820834527 0.67455534405292 0.869002464041286 0.358974358974359 4.1 4 1 enlarged kidney 0.180735751163879 0.611673715673671 0.867831301690826 0.358490566037736 4.1 4 1 abnormal cranium morphology 0.0584734335450267 0.303976313361032 0.867149580322648 0.358208955223881 4.1 4 1 abnormal skeleton development 0.120231698972162 0.466942000301722 0.866703515723717 0.358024691358025 4.1 4 1 impaired fertilization 0.144484337497743 0.539241994787152 0.864568778000259 0.357142857142857 4.1 4 1 abnormal eye development 0.177846485428848 0.610916457667644 0.864568778000259 0.357142857142857 4.1 4 1 rib bifurcation 0.285752862413233 0.67455534405292 0.864568778000259 0.357142857142857 4.1 4 1 abnormal jaw morphology 0.285752862413233 0.67455534405292 0.864568778000259 0.357142857142857 4.1 4 1 absent corpus callosum 0.285752862413233 0.67455534405292 0.864568778000259 0.357142857142857 4.1 4 1 corneal vascularization 0.285752862413233 0.67455534405292 0.864568778000259 0.357142857142857 4.1 4 1 extended life span 0.390754690606189 0.812371327106473 0.864568778000259 0.357142857142857 4.1 4 1 abnormal fluid regulation 0.390754690606189 0.812371327106473 0.864568778000259 0.357142857142857 4.1 4 1 abnormal ventral body wall morphology 0.390754690606189 0.812371327106473 0.864568778000259 0.357142857142857 4.1 4 1 abnormal decidualization 0.390754690606189 0.812371327106473 0.864568778000259 0.357142857142857 4.1 4 1 abnormal pancreas development 0.390754690606189 0.812371327106473 0.864568778000259 0.357142857142857 4.1 4 1 split sternum 0.390754690606189 0.812371327106473 0.864568778000259 0.357142857142857 4.1 4 1 increased pulmonary respiratory rate 0.390754690606189 0.812371327106473 0.864568778000259 0.357142857142857 4.1 4 1 pulmonary alveolar hemorrhage 0.390754690606189 0.812371327106473 0.864568778000259 0.357142857142857 4.1 4 1 abnormal respiratory motile cilium physiology 0.390754690606189 0.812371327106473 0.864568778000259 0.357142857142857 4.1 4 1 abnormal ovarian follicle morphology 0.218237877435606 0.665277843285625 0.860726250098036 0.355555555555556 4.1 4 1 albuminuria 0.218237877435606 0.665277843285625 0.860726250098036 0.355555555555556 4.1 4 1 lethality at weaning, complete penetrance 0.218237877435606 0.665277843285625 0.860726250098036 0.355555555555556 4.1 4 1 absent mature ovarian follicles 0.279018594384705 0.67455534405292 0.858990914916387 0.354838709677419 4.1 4 1 abnormal postnatal growth/weight/body size 0.279018594384705 0.67455534405292 0.858990914916387 0.354838709677419 4.1 4 1 abnormal retinal photoreceptor layer morphology 0.279018594384705 0.67455534405292 0.858990914916387 0.354838709677419 4.1 4 1 decreased susceptibility to bacterial infection induced morbidity/mortality 0.279018594384705 0.67455534405292 0.858990914916387 0.354838709677419 4.1 4 1 increased circulating glucose level 0.0640717711233003 0.321412328751695 0.858437084539265 0.354609929078014 4.1 4 1 abnormal cardiovascular system morphology 0.214154694867367 0.654836881969976 0.857364038183591 0.354166666666667 4.1 4 1 decreased susceptibility to injury 0.166484349234035 0.583406784382307 0.854397380612021 0.352941176470588 4.1 4 1 abnormal cervical vertebrae morphology 0.210143605929808 0.643758891318223 0.854397380612021 0.352941176470588 4.1 4 1 increased kidney weight 0.210143605929808 0.643758891318223 0.854397380612021 0.352941176470588 4.1 4 1 overexpanded pulmonary alveoli 0.272537019694265 0.67455534405292 0.854397380612021 0.352941176470588 4.1 4 1 abnormal vision 0.272537019694265 0.67455534405292 0.854397380612021 0.352941176470588 4.1 4 1 decreased osteoblast cell number 0.272537019694265 0.67455534405292 0.854397380612021 0.352941176470588 4.1 4 1 distended urinary bladder 0.375918665271852 0.7854663417587 0.854397380612021 0.352941176470588 4.1 4 1 absence seizures 0.375918665271852 0.7854663417587 0.854397380612021 0.352941176470588 4.1 4 1 abnormal duodenum morphology 0.375918665271852 0.7854663417587 0.854397380612021 0.352941176470588 4.1 4 1 aminoaciduria 0.375918665271852 0.7854663417587 0.854397380612021 0.352941176470588 4.1 4 1 increased trabecular bone mass 0.375918665271852 0.7854663417587 0.854397380612021 0.352941176470588 4.1 4 1 abnormal electroretinogram waveform feature 0.375918665271852 0.7854663417587 0.854397380612021 0.352941176470588 4.1 4 1 respiratory distress 0.0499050221517568 0.271045289525098 0.853574261748233 0.352601156069364 4.1 4 1 abnormal suckling behavior 0.131934030489969 0.506069238001229 0.852779203754801 0.352272727272727 4.1 4 1 decreased liver weight 0.163721040245025 0.578488760808948 0.852391752958002 0.352112676056338 4.1 4 1 improved glucose tolerance 0.0405409668970387 0.228674955003138 0.852217795457399 0.352040816326531 4.1 4 1 increased brown adipose tissue amount 0.266297322577468 0.67455534405292 0.850548743762417 0.351351351351351 4.1 4 1 cleft secondary palate 0.127899711662679 0.49173188989322 0.849852713693872 0.351063829787234 4.1 4 1 obese 0.158309980722237 0.563370639551596 0.848849345672982 0.350649350649351 4.1 4 1 increased susceptibility to weight loss 0.260287151424413 0.67455534405292 0.847277402440254 0.35 4.1 4 1 abnormal lens epithelium morphology 0.362754889158135 0.761236125036654 0.847277402440254 0.35 4.1 4 1 kidney atrophy 0.362754889158135 0.761236125036654 0.847277402440254 0.35 4.1 4 1 decreased circulating VLDL cholesterol level 0.362754889158135 0.761236125036654 0.847277402440254 0.35 4.1 4 1 abnormal circulating cytokine level 0.362754889158135 0.761236125036654 0.847277402440254 0.35 4.1 4 1 nuclear cataracts 0.362754889158135 0.761236125036654 0.847277402440254 0.35 4.1 4 1 decreased muscle cell glucose uptake 0.362754889158135 0.761236125036654 0.847277402440254 0.35 4.1 4 1 abnormal eye physiology 0.198580319966856 0.633069030194561 0.847277402440254 0.35 4.1 4 1 abnormal hair follicle morphology 0.194887372861376 0.633069030194561 0.845356138489142 0.349206349206349 4.1 4 1 abnormal male reproductive system morphology 0.254493862896018 0.67455534405292 0.84446252734909 0.348837209302326 4.1 4 1 delayed endochondral bone ossification 0.254493862896018 0.67455534405292 0.84446252734909 0.348837209302326 4.1 4 1 abnormal regulatory T cell physiology 0.350860187066921 0.739004839397939 0.842014809878513 0.347826086956522 4.1 4 1 abnormal corneal stroma morphology 0.350860187066921 0.739004839397939 0.842014809878513 0.347826086956522 4.1 4 1 increased susceptibility to fungal infection 0.350860187066921 0.739004839397939 0.842014809878513 0.347826086956522 4.1 4 1 abnormal heart left ventricle morphology 0.184289364150735 0.623276401529508 0.840552978611363 0.347222222222222 4.1 4 1 abnormal long bone hypertrophic chondrocyte zone 0.243509290172787 0.67455534405292 0.839866812914538 0.346938775510204 4.1 4 1 abnormal skin condition 0.238295358825659 0.67455534405292 0.837966661754098 0.346153846153846 4.1 4 1 abnormal hair growth 0.238295358825659 0.67455534405292 0.837966661754098 0.346153846153846 4.1 4 1 increased susceptibility to injury 0.238295358825659 0.67455534405292 0.837966661754098 0.346153846153846 4.1 4 1 abnormal stomach morphology 0.339970761548622 0.717587839925497 0.837966661754098 0.346153846153846 4.1 4 1 abnormal contextual conditioning behavior 0.233253168713238 0.67455534405292 0.83627379981116 0.345454545454545 4.1 4 1 abnormal microglial cell morphology 0.329903317547381 0.708938429602875 0.834756061517492 0.344827586206897 4.1 4 1 short sternum 0.329903317547381 0.708938429602875 0.834756061517492 0.344827586206897 4.1 4 1 abnormal maternal nurturing 0.223647046550388 0.67455534405292 0.833387608957627 0.344262295081967 4.1 4 1 abnormal crypts of Lieberkuhn morphology 0.320524558314135 0.708938429602875 0.83214744882525 0.34375 4.1 4 1 abnormal lumbar vertebrae morphology 0.320524558314135 0.708938429602875 0.83214744882525 0.34375 4.1 4 1 hyporesponsive to tactile stimuli 0.303453790546313 0.697635216251344 0.828165882084459 0.342105263157895 4.1 4 1 palatal shelves fail to meet at midline 0.29562198127423 0.681519627821731 0.826612099941711 0.341463414634146 4.1 4 1 circling 0.190518845154714 0.633069030194561 0.825917467924954 0.341176470588235 4.1 4 1 increased liver weight 0.186876743108842 0.631597688156584 0.825270197182066 0.340909090909091 4.1 4 1 abnormal astrocyte morphology 0.288188474423838 0.67455534405292 0.825270197182066 0.340909090909091 4.1 4 1 decreased heart rate 0.173222676349302 0.603489366132897 0.823069476656247 0.34 4.1 4 1 abnormal seminal vesicle morphology 0.261705249318735 0.67455534405292 0.821340339100246 0.339285714285714 4.1 4 1 abnormal thoracic vertebrae morphology 0.255759911696655 0.67455534405292 0.820607653695161 0.338983050847458 4.1 4 1 increased circulating creatinine level 0.210877052329424 0.645608206362391 0.816313776437454 0.337209302325581 4.1 4 1 decreased cardiac muscle contractility 0.187248801445853 0.632425517442715 0.814689810038706 0.336538461538462 4.1 4 1 abnormal trabecular bone morphology 0.170293453581756 0.593700022122801 0.813711791059068 0.336134453781513 4.1 4 1 abnormal optic nerve morphology 0.332240110479081 0.708938429602875 0.806930859466909 0.333333333333333 4.1 4 1 abnormal scapula morphology 0.418634180208895 0.85567175289205 0.806930859466909 0.333333333333333 4.1 4 1 dry skin 0.418634180208895 0.85567175289205 0.806930859466909 0.333333333333333 4.1 4 1 abnormal clavicle morphology 0.418634180208895 0.85567175289205 0.806930859466909 0.333333333333333 4.1 4 1 abnormal bile salt homeostasis 0.418634180208895 0.85567175289205 0.806930859466909 0.333333333333333 4.1 4 1 increased keratinocyte proliferation 0.418634180208895 0.85567175289205 0.806930859466909 0.333333333333333 4.1 4 1 abnormal blood homeostasis 0.193595443504535 0.633069030194561 0.806930859466909 0.333333333333333 4.1 4 1 deafness 0.213790027995344 0.654123855643811 0.806930859466909 0.333333333333333 4.1 4 1 abnormal urine homeostasis 0.218192049302335 0.665277843285625 0.806930859466909 0.333333333333333 4.1 4 1 abnormal long bone epiphyseal plate morphology 0.284349707561554 0.67455534405292 0.806930859466909 0.333333333333333 4.1 4 1 abnormal incisor morphology 0.284349707561554 0.67455534405292 0.806930859466909 0.333333333333333 4.1 4 1 abnormal thrombosis 0.306465255004675 0.7030020303743 0.806930859466909 0.333333333333333 4.1 4 1 altered response to myocardial infarction 0.323163772917954 0.708938429602875 0.806930859466909 0.333333333333333 4.1 4 1 oligodactyly 0.314590637758631 0.708938429602875 0.806930859466909 0.333333333333333 4.1 4 1 decreased osteoclast cell number 0.323163772917954 0.708938429602875 0.806930859466909 0.333333333333333 4.1 4 1 reduced long term depression 0.352189052802461 0.741489859370395 0.806930859466909 0.333333333333333 4.1 4 1 abnormal tooth development 0.363251168007441 0.761236125036654 0.806930859466909 0.333333333333333 4.1 4 1 dextrocardia 0.363251168007441 0.761236125036654 0.806930859466909 0.333333333333333 4.1 4 1 absent vibrissae 0.363251168007441 0.761236125036654 0.806930859466909 0.333333333333333 4.1 4 1 cardiovascular system phenotype 0.363251168007441 0.761236125036654 0.806930859466909 0.333333333333333 4.1 4 1 emphysema 0.375209929754168 0.7854663417587 0.806930859466909 0.333333333333333 4.1 4 1 thin epidermis 0.388245626980519 0.810202178786948 0.806930859466909 0.333333333333333 4.1 4 1 cryptorchism 0.388245626980519 0.810202178786948 0.806930859466909 0.333333333333333 4.1 4 1 abnormal bone trabecula morphology 0.388245626980519 0.810202178786948 0.806930859466909 0.333333333333333 4.1 4 1 abnormal foregut morphology 0.402604201619455 0.832829897320909 0.806930859466909 0.333333333333333 4.1 4 1 abnormal body weight 0.402604201619455 0.832829897320909 0.806930859466909 0.333333333333333 4.1 4 1 increased stereotypic behavior 0.402604201619455 0.832829897320909 0.806930859466909 0.333333333333333 4.1 4 1 apnea 0.402604201619455 0.832829897320909 0.806930859466909 0.333333333333333 4.1 4 1 abnormal sensory capabilities/reflexes/nociception 0.402604201619455 0.832829897320909 0.806930859466909 0.333333333333333 4.1 4 1 increased circulating total protein level 0.402604201619455 0.832829897320909 0.806930859466909 0.333333333333333 4.1 4 1 abnormal truncus arteriosus septation 0.402604201619455 0.832829897320909 0.806930859466909 0.333333333333333 4.1 4 1 abnormal fontanelle morphology 0.458083507392398 0.86837954869208 0.806930859466909 0.333333333333333 4.1 4 1 abnormal stomach glandular epithelium morphology 0.436853801305539 0.86837954869208 0.806930859466909 0.333333333333333 4.1 4 1 cortical renal glomerulopathies 0.436853801305539 0.86837954869208 0.806930859466909 0.333333333333333 4.1 4 1 abnormal radius morphology 0.436853801305539 0.86837954869208 0.806930859466909 0.333333333333333 4.1 4 1 decreased salivation 0.458083507392398 0.86837954869208 0.806930859466909 0.333333333333333 4.1 4 1 abnormal mammary gland morphology 0.436853801305539 0.86837954869208 0.806930859466909 0.333333333333333 4.1 4 1 absent spleen 0.436853801305539 0.86837954869208 0.806930859466909 0.333333333333333 4.1 4 1 no suckling reflex 0.458083507392398 0.86837954869208 0.806930859466909 0.333333333333333 4.1 4 1 abnormal respiratory system morphology 0.458083507392398 0.86837954869208 0.806930859466909 0.333333333333333 4.1 4 1 abnormal cricoid cartilage morphology 0.458083507392398 0.86837954869208 0.806930859466909 0.333333333333333 4.1 4 1 acidosis 0.436853801305539 0.86837954869208 0.806930859466909 0.333333333333333 4.1 4 1 increased circulating renin level 0.436853801305539 0.86837954869208 0.806930859466909 0.333333333333333 4.1 4 1 decreased aggression towards males 0.458083507392398 0.86837954869208 0.806930859466909 0.333333333333333 4.1 4 1 decreased heart rate variability 0.436853801305539 0.86837954869208 0.806930859466909 0.333333333333333 4.1 4 1 abnormal eye anterior chamber morphology 0.436853801305539 0.86837954869208 0.806930859466909 0.333333333333333 4.1 4 1 abnormal cerebral aqueduct morphology 0.458083507392398 0.86837954869208 0.806930859466909 0.333333333333333 4.1 4 1 abnormal Muller cell morphology 0.458083507392398 0.86837954869208 0.806930859466909 0.333333333333333 4.1 4 1 abnormal secondary palate development 0.458083507392398 0.86837954869208 0.806930859466909 0.333333333333333 4.1 4 1 increased circulating alanine transaminase level 0.247737716898255 0.67455534405292 0.806930859466909 0.333333333333333 4.1 4 1 reduced long term potentiation 0.215438028494613 0.658356383145393 0.79972611965024 0.330357142857143 4.1 4 1 small kidney 0.254540836437654 0.67455534405292 0.79776119060933 0.329545454545455 4.1 4 1 decreased kidney weight 0.339576347434483 0.717059562175956 0.791412958323314 0.326923076923077 4.1 4 1 abnormal epidermis stratum corneum morphology 0.349054321436616 0.736448366898712 0.790462882743094 0.326530612244898 4.1 4 1 abnormal sleep pattern 0.35909536908201 0.755710431972505 0.789388884261106 0.326086956521739 4.1 4 1 polyuria 0.304344195574817 0.699359063734278 0.785971616363872 0.324675324675325 4.1 4 1 abnormal long bone metaphysis morphology 0.393417083310458 0.816882299444711 0.785121917319154 0.324324324324324 4.1 4 1 abnormal breathing pattern 0.393417083310458 0.816882299444711 0.785121917319154 0.324324324324324 4.1 4 1 decreased width of hypertrophic chondrocyte zone 0.393417083310458 0.816882299444711 0.785121917319154 0.324324324324324 4.1 4 1 short maxilla 0.406636195461568 0.835858204198527 0.783197598894352 0.323529411764706 4.1 4 1 increased susceptibility to weight gain 0.406636195461568 0.835858204198527 0.783197598894352 0.323529411764706 4.1 4 1 abnormal nose morphology 0.421015327549151 0.860185320146623 0.78090083174217 0.32258064516129 4.1 4 1 hydronephrosis 0.315753859460219 0.708938429602875 0.778111900200233 0.321428571428571 4.1 4 1 abnormal nervous system electrophysiology 0.315753859460219 0.708938429602875 0.778111900200233 0.321428571428571 4.1 4 1 enhanced coordination 0.436794831249234 0.86837954869208 0.778111900200233 0.321428571428571 4.1 4 1 decreased circulating progesterone level 0.436794831249234 0.86837954869208 0.778111900200233 0.321428571428571 4.1 4 1 abnormal inner ear vestibule morphology 0.454301886289099 0.86837954869208 0.774653625088232 0.32 4.1 4 1 decreased placenta weight 0.454301886289099 0.86837954869208 0.774653625088232 0.32 4.1 4 1 short femur 0.333740235608641 0.708938429602875 0.770252184036595 0.318181818181818 4.1 4 1 abnormal amino acid level 0.407845458467123 0.835858204198527 0.770252184036595 0.318181818181818 4.1 4 1 abnormal basisphenoid bone morphology 0.473997910918662 0.86837954869208 0.770252184036595 0.318181818181818 4.1 4 1 increased coping response 0.473997910918662 0.86837954869208 0.770252184036595 0.318181818181818 4.1 4 1 abnormal retinal outer plexiform layer morphology 0.473997910918662 0.86837954869208 0.770252184036595 0.318181818181818 4.1 4 1 abnormal basement membrane morphology 0.473997910918662 0.86837954869208 0.770252184036595 0.318181818181818 4.1 4 1 abnormal blood-brain barrier function 0.473997910918662 0.86837954869208 0.770252184036595 0.318181818181818 4.1 4 1 failure of palatal shelf elevation 0.473997910918662 0.86837954869208 0.770252184036595 0.318181818181818 4.1 4 1 abnormal response/metabolism to endogenous compounds 0.349816437479803 0.737743440636719 0.767568378517303 0.317073170731707 4.1 4 1 decreased grooming behavior 0.496562985076757 0.86837954869208 0.764460814231808 0.315789473684211 4.1 4 1 decreased germ cell number 0.496562985076757 0.86837954869208 0.764460814231808 0.315789473684211 4.1 4 1 increased left ventricle weight 0.496562985076757 0.86837954869208 0.764460814231808 0.315789473684211 4.1 4 1 abnormal sternebra morphology 0.496562985076757 0.86837954869208 0.764460814231808 0.315789473684211 4.1 4 1 abnormal cochlear inner hair cell morphology 0.496562985076757 0.86837954869208 0.764460814231808 0.315789473684211 4.1 4 1 eyelids fail to open 0.496562985076757 0.86837954869208 0.764460814231808 0.315789473684211 4.1 4 1 decreased circulating magnesium level 0.496562985076757 0.86837954869208 0.764460814231808 0.315789473684211 4.1 4 1 decreased liver glycogen level 0.496562985076757 0.86837954869208 0.764460814231808 0.315789473684211 4.1 4 1 thin interventricular septum 0.496562985076757 0.86837954869208 0.764460814231808 0.315789473684211 4.1 4 1 abnormal circulating amino acid level 0.396399167445329 0.822730854418237 0.764460814231808 0.315789473684211 4.1 4 1 impaired adaptive thermogenesis 0.450133024599506 0.86837954869208 0.760820524640228 0.314285714285714 4.1 4 1 abnormal hair shaft morphology 0.432495278061138 0.86837954869208 0.756497680750227 0.3125 4.1 4 1 abnormal hair follicle orientation 0.523057794847 0.893310171425961 0.756497680750227 0.3125 4.1 4 1 reduced male mating frequency 0.523057794847 0.893310171425961 0.756497680750227 0.3125 4.1 4 1 abnormal intestinal absorption 0.523057794847 0.893310171425961 0.756497680750227 0.3125 4.1 4 1 white spotting 0.523057794847 0.893310171425961 0.756497680750227 0.3125 4.1 4 1 paternal imprinting 0.523057794847 0.893310171425961 0.756497680750227 0.3125 4.1 4 1 abnormal pulmonary elastic fiber morphology 0.523057794847 0.893310171425961 0.756497680750227 0.3125 4.1 4 1 increased thymus weight 0.523057794847 0.893310171425961 0.756497680750227 0.3125 4.1 4 1 abnormal amnion morphology 0.523057794847 0.893310171425961 0.756497680750227 0.3125 4.1 4 1 decreased circulating growth hormone level 0.523057794847 0.893310171425961 0.756497680750227 0.3125 4.1 4 1 decreased circulating prolactin level 0.523057794847 0.893310171425961 0.756497680750227 0.3125 4.1 4 1 abnormal intestinal lipid absorption 0.523057794847 0.893310171425961 0.756497680750227 0.3125 4.1 4 1 decreased circulating triiodothyronine level 0.523057794847 0.893310171425961 0.756497680750227 0.3125 4.1 4 1 impaired behavioral response to addictive substance 0.523057794847 0.893310171425961 0.756497680750227 0.3125 4.1 4 1 abnormal thoracic cage shape 0.523057794847 0.893310171425961 0.756497680750227 0.3125 4.1 4 1 dilated respiratory conducting tubes 0.523057794847 0.893310171425961 0.756497680750227 0.3125 4.1 4 1 decreased adipocyte glucose uptake 0.523057794847 0.893310171425961 0.756497680750227 0.3125 4.1 4 1 irregular heartbeat 0.446088800328038 0.86837954869208 0.753135468835782 0.311111111111111 4.1 4 1 abnormal enzyme/coenzyme level 0.429844334192616 0.864379774700187 0.751280455365743 0.310344827586207 4.1 4 1 abnormal circulating glucose level 0.484896012415068 0.86837954869208 0.751280455365743 0.310344827586207 4.1 4 1 focal hair loss 0.484896012415068 0.86837954869208 0.751280455365743 0.310344827586207 4.1 4 1 decreased retinal photoreceptor cell number 0.484896012415068 0.86837954869208 0.751280455365743 0.310344827586207 4.1 4 1 stomach inflammation 0.484896012415068 0.86837954869208 0.751280455365743 0.310344827586207 4.1 4 1 corneal opacity 0.416184801720611 0.852416380634022 0.750104742603042 0.309859154929577 4.1 4 1 decreased body temperature 0.455373948130883 0.86837954869208 0.744859254892531 0.307692307692308 4.1 4 1 small seminal vesicle 0.505115719507088 0.876814621265794 0.744859254892531 0.307692307692308 4.1 4 1 abnormal iris morphology 0.476294748668001 0.86837954869208 0.744859254892531 0.307692307692308 4.1 4 1 seizures 0.399189980128248 0.828177711066736 0.743225791614258 0.307017543859649 4.1 4 1 head tilt 0.493228372190206 0.86837954869208 0.739686621178 0.305555555555556 4.1 4 1 abnormal retinal blood vessel morphology 0.493228372190206 0.86837954869208 0.739686621178 0.305555555555556 4.1 4 1 abnormal coat appearance 0.458042754846259 0.86837954869208 0.736762958643699 0.304347826086957 4.1 4 1 fragile skeleton 0.527870665103798 0.897217819915064 0.736762958643699 0.304347826086957 4.1 4 1 abnormal blood vessel physiology 0.527870665103798 0.897217819915064 0.736762958643699 0.304347826086957 4.1 4 1 abnormal innervation pattern to muscle 0.527870665103798 0.897217819915064 0.736762958643699 0.304347826086957 4.1 4 1 abnormal cranial nerve morphology 0.527870665103798 0.897217819915064 0.736762958643699 0.304347826086957 4.1 4 1 bidirectional circling 0.527870665103798 0.897217819915064 0.736762958643699 0.304347826086957 4.1 4 1 hypotension 0.527870665103798 0.897217819915064 0.736762958643699 0.304347826086957 4.1 4 1 decreased epididymis weight 0.527870665103798 0.897217819915064 0.736762958643699 0.304347826086957 4.1 4 1 abnormal ulna morphology 0.527870665103798 0.897217819915064 0.736762958643699 0.304347826086957 4.1 4 1 abnormal lens development 0.527870665103798 0.897217819915064 0.736762958643699 0.304347826086957 4.1 4 1 abnormal chondrocyte physiology 0.527870665103798 0.897217819915064 0.736762958643699 0.304347826086957 4.1 4 1 abnormal basicranium morphology 0.527870665103798 0.897217819915064 0.736762958643699 0.304347826086957 4.1 4 1 abnormal hepatocyte physiology 0.527870665103798 0.897217819915064 0.736762958643699 0.304347826086957 4.1 4 1 enhanced long term potentiation 0.47668890426832 0.86837954869208 0.73488346130022 0.303571428571429 4.1 4 1 impaired swimming 0.470287352982033 0.86837954869208 0.733573508606281 0.303030303030303 4.1 4 1 abnormal tail morphology 0.470287352982033 0.86837954869208 0.733573508606281 0.303030303030303 4.1 4 1 dilated heart atrium 0.511667637720557 0.887259148713758 0.733573508606281 0.303030303030303 4.1 4 1 single kidney 0.511667637720557 0.887259148713758 0.733573508606281 0.303030303030303 4.1 4 1 abnormal organ of Corti morphology 0.500017163860907 0.868873695497036 0.731867523702545 0.302325581395349 4.1 4 1 abnormal intestinal mucosa morphology 0.500017163860907 0.868873695497036 0.731867523702545 0.302325581395349 4.1 4 1 abnormal blood circulation 0.500017163860907 0.868873695497036 0.731867523702545 0.302325581395349 4.1 4 1 decreased anxiety-related response 0.451694359486008 0.86837954869208 0.728205897567698 0.300813008130081 4.1 4 1 abnormal kidney development 0.496614544435914 0.86837954869208 0.726237773520218 0.3 4.1 4 1 abnormal social investigation 0.482062156050913 0.86837954869208 0.726237773520218 0.3 4.1 4 1 abnormal axon extension 0.505779729722686 0.877661023847353 0.726237773520218 0.3 4.1 4 1 abnormal skin pigmentation 0.517059830675383 0.888250227075287 0.726237773520218 0.3 4.1 4 1 abnormal response to new environment 0.531904333555454 0.903456490077973 0.726237773520218 0.3 4.1 4 1 abnormal hearing physiology 0.553909311899024 0.930903091731343 0.726237773520218 0.3 4.1 4 1 abnormal heart right ventricle morphology 0.553909311899024 0.930903091731343 0.726237773520218 0.3 4.1 4 1 abnormal postnatal subventricular zone morphology 0.553909311899024 0.930903091731343 0.726237773520218 0.3 4.1 4 1 decreased compact bone thickness 0.501768886193244 0.871613201400625 0.722624650268873 0.298507462686567 4.1 4 1 abnormal innervation 0.521693180420659 0.893310171425961 0.721087151012982 0.297872340425532 4.1 4 1 abnormal locomotor activation 0.503008281438698 0.873461151887443 0.718257138646369 0.296703296703297 4.1 4 1 abnormal mandible morphology 0.525789488469225 0.897217819915064 0.717271875081697 0.296296296296296 4.1 4 1 polyphagia 0.525789488469225 0.897217819915064 0.717271875081697 0.296296296296296 4.1 4 1 abnormal long bone morphology 0.529484297632529 0.899653135492429 0.714332236249395 0.295081967213115 4.1 4 1 abnormal cued conditioning behavior 0.541627984962399 0.919658438630694 0.711997817176684 0.294117647058824 4.1 4 1 impaired synaptic plasticity 0.555430738661802 0.930903091731343 0.711997817176684 0.294117647058824 4.1 4 1 decreased pancreatic beta cell number 0.555430738661802 0.930903091731343 0.711997817176684 0.294117647058824 4.1 4 1 increased width of hypertrophic chondrocyte zone 0.555430738661802 0.930903091731343 0.711997817176684 0.294117647058824 4.1 4 1 abnormal vagus nerve morphology 0.584365765503312 0.959795207454267 0.711997817176684 0.294117647058824 4.1 4 1 abnormal touch/ nociception 0.584365765503312 0.959795207454267 0.711997817176684 0.294117647058824 4.1 4 1 abnormal glutamate-mediated receptor currents 0.584365765503312 0.959795207454267 0.711997817176684 0.294117647058824 4.1 4 1 decreased vasoconstriction 0.584365765503312 0.959795207454267 0.711997817176684 0.294117647058824 4.1 4 1 nephrocalcinosis 0.584365765503312 0.959795207454267 0.711997817176684 0.294117647058824 4.1 4 1 abnormal tarsal bone morphology 0.584365765503312 0.959795207454267 0.711997817176684 0.294117647058824 4.1 4 1 decreased growth hormone level 0.584365765503312 0.959795207454267 0.711997817176684 0.294117647058824 4.1 4 1 coloboma 0.584365765503312 0.959795207454267 0.711997817176684 0.294117647058824 4.1 4 1 abnormal digestive system morphology 0.57945097359735 0.954243162412055 0.706064502033545 0.291666666666667 4.1 4 1 abnormal primitive streak formation 0.57945097359735 0.954243162412055 0.706064502033545 0.291666666666667 4.1 4 1 abnormal cardiac muscle contractility 0.57945097359735 0.954243162412055 0.706064502033545 0.291666666666667 4.1 4 1 abnormal impulse conducting system conduction 0.57945097359735 0.954243162412055 0.706064502033545 0.291666666666667 4.1 4 1 abnormal osteoblast morphology 0.57945097359735 0.954243162412055 0.706064502033545 0.291666666666667 4.1 4 1 abnormal joint morphology 0.560063054271671 0.930903091731343 0.704230568262029 0.290909090909091 4.1 4 1 abnormal eyelid morphology 0.577268017830759 0.952540095757223 0.702810748567953 0.290322580645161 4.1 4 1 abnormal epidermal layer morphology 0.563406876221723 0.930903091731343 0.701679008232095 0.289855072463768 4.1 4 1 abnormal food intake 0.563406876221723 0.930903091731343 0.701679008232095 0.289855072463768 4.1 4 1 impaired branching involved in ureteric bud morphogenesis 0.576407849008547 0.951436313476285 0.700755746379158 0.289473684210526 4.1 4 1 decreased threshold for auditory brainstem response 0.576407849008547 0.951436313476285 0.700755746379158 0.289473684210526 4.1 4 1 abnormal spatial learning 0.5741482624798 0.948335858511622 0.698019945919228 0.288343558282209 4.1 4 1 increased anxiety-related response 0.579033135113449 0.954243162412055 0.696630957813159 0.287769784172662 4.1 4 1 decreased urine osmolality 0.594067433908571 0.97333183412024 0.691655022400207 0.285714285714286 4.1 4 1 small ears 0.608019364575075 0.989498311665358 0.691655022400207 0.285714285714286 4.1 4 1 abnormal anxiety-related response 0.608019364575075 0.989498311665358 0.691655022400207 0.285714285714286 4.1 4 1 hypoalgesia 0.608019364575075 0.989498311665358 0.691655022400207 0.285714285714286 4.1 4 1 short mandible 0.593412714273011 0.97333183412024 0.691655022400207 0.285714285714286 4.1 4 1 abnormal stria vascularis morphology 0.601335918825892 0.979582906404326 0.691655022400207 0.285714285714286 4.1 4 1 abnormal respiration 0.601335918825892 0.979582906404326 0.691655022400207 0.285714285714286 4.1 4 1 abnormal retinal inner nuclear layer morphology 0.601335918825892 0.979582906404326 0.691655022400207 0.285714285714286 4.1 4 1 abnormal hormone level 0.601335918825892 0.979582906404326 0.691655022400207 0.285714285714286 4.1 4 1 prolonged QRS complex duration 0.601335918825892 0.979582906404326 0.691655022400207 0.285714285714286 4.1 4 1 abnormal lymphatic vessel morphology 0.620536522661999 0.992071507904436 0.680847912675204 0.28125 4.1 4 1 abnormal auditory brainstem response waveform shape 0.620536522661999 0.992071507904436 0.680847912675204 0.28125 4.1 4 1 abnormal hindlimb morphology 0.62840154109197 0.992071507904436 0.677821921952203 0.28 4.1 4 1 diaphragmatic hernia 0.628120063106115 0.992071507904436 0.677821921952203 0.28 4.1 4 1 abnormal vertebrae development 0.628120063106115 0.992071507904436 0.677821921952203 0.28 4.1 4 1 increased liver glycogen level 0.628120063106115 0.992071507904436 0.677821921952203 0.28 4.1 4 1 right pulmonary isomerism 0.641101136348609 0.992071507904436 0.672442382889091 0.277777777777778 4.1 4 1 abnormal phrenic nerve morphology 0.641101136348609 0.992071507904436 0.672442382889091 0.277777777777778 4.1 4 1 abnormal metacarpal bone morphology 0.641101136348609 0.992071507904436 0.672442382889091 0.277777777777778 4.1 4 1 abnormal body wall morphology 0.641101136348609 0.992071507904436 0.672442382889091 0.277777777777778 4.1 4 1 decreased activity of thyroid 0.641101136348609 0.992071507904436 0.672442382889091 0.277777777777778 4.1 4 1 decreased pulmonary respiratory rate 0.641101136348609 0.992071507904436 0.672442382889091 0.277777777777778 4.1 4 1 atrioventricular block 0.641101136348609 0.992071507904436 0.672442382889091 0.277777777777778 4.1 4 1 abnormal digit morphology 0.650190700009831 0.992463293950316 0.672442382889091 0.277777777777778 4.1 4 1 abnormal tibia morphology 0.647324543670413 0.992463293950316 0.669580925940626 0.276595744680851 4.1 4 1 pulmonary hypoplasia 0.647324543670413 0.992463293950316 0.669580925940626 0.276595744680851 4.1 4 1 abnormal parietal bone morphology 0.645693978410967 0.992071507904436 0.667804849213993 0.275862068965517 4.1 4 1 absent long term depression 0.645693978410967 0.992071507904436 0.667804849213993 0.275862068965517 4.1 4 1 abnormal response to novel object 0.661234778546403 1 0.664531296031572 0.274509803921569 4.1 4 1 impaired righting response 0.691860742819219 1 0.662532705667567 0.273684210526316 4.1 4 1 intestinal ulcer 0.658277409696231 0.997541916917072 0.660216157745653 0.272727272727273 4.1 4 1 decreased airway responsiveness 0.658277409696231 0.997541916917072 0.660216157745653 0.272727272727273 4.1 4 1 decreased cardiac output 0.658277409696231 0.997541916917072 0.660216157745653 0.272727272727273 4.1 4 1 increased circulating creatine kinase level 0.658277409696231 0.997541916917072 0.660216157745653 0.272727272727273 4.1 4 1 abnormal photoreceptor outer segment morphology 0.667318167255577 1 0.660216157745653 0.272727272727273 4.1 4 1 head tossing 0.661362354515039 1 0.660216157745653 0.272727272727273 4.1 4 1 abnormal eye electrophysiology 0.714125325220604 1 0.660216157745653 0.272727272727273 4.1 4 1 decreased sensitivity to xenobiotic induced morbidity/mortality 0.661362354515039 1 0.660216157745653 0.272727272727273 4.1 4 1 dehydration 0.6923135513715 1 0.657072271280197 0.271428571428571 4.1 4 1 abnormal action potential 0.6923135513715 1 0.657072271280197 0.271428571428571 4.1 4 1 abnormal colon morphology 0.686153113128733 1 0.656486122956129 0.271186440677966 4.1 4 1 increased insulin secretion 0.675531694719813 1 0.654268264432629 0.27027027027027 4.1 4 1 abnormal humerus morphology 0.675531694719813 1 0.654268264432629 0.27027027027027 4.1 4 1 abnormal Schwann cell morphology 0.673437452853124 1 0.651751848030965 0.269230769230769 4.1 4 1 abnormal ocular fundus morphology 0.673437452853124 1 0.651751848030965 0.269230769230769 4.1 4 1 abnormal brain wave pattern 0.692417546214893 1 0.651751848030965 0.269230769230769 4.1 4 1 increased percent body fat/body weight 0.692417546214893 1 0.651751848030965 0.269230769230769 4.1 4 1 short humerus 0.688483747020274 1 0.649480935668487 0.268292682926829 4.1 4 1 abnormal skin physiology 0.699497736222205 1 0.640798035459016 0.264705882352941 4.1 4 1 short limbs 0.752782316556991 1 0.63997964716341 0.264367816091954 4.1 4 1 flaky skin 0.692721904659984 1 0.637050678526507 0.263157894736842 4.1 4 1 delayed sexual maturation 0.692721904659984 1 0.637050678526507 0.263157894736842 4.1 4 1 osteoarthritis 0.692721904659984 1 0.637050678526507 0.263157894736842 4.1 4 1 right-sided stomach 0.692721904659984 1 0.637050678526507 0.263157894736842 4.1 4 1 abnormal vibrissa morphology 0.721536521575521 1 0.634017103866857 0.261904761904762 4.1 4 1 increased susceptibility to age related obesity 0.704303319552384 1 0.631511107408885 0.260869565217391 4.1 4 1 abnormal crista ampullaris morphology 0.704303319552384 1 0.631511107408885 0.260869565217391 4.1 4 1 abnormal chondrocyte morphology 0.749424468054083 1 0.627612890696485 0.259259259259259 4.1 4 1 wrinkled skin 0.715127098520321 1 0.627612890696485 0.259259259259259 4.1 4 1 abnormal brain commissure morphology 0.715127098520321 1 0.627612890696485 0.259259259259259 4.1 4 1 abnormal intestine physiology 0.725264731348288 1 0.624720665393736 0.258064516129032 4.1 4 1 increased vascular permeability 0.743758955297507 1 0.620716045743776 0.256410256410256 4.1 4 1 abnormal excitatory postsynaptic potential 0.799201903839464 1 0.619959074956283 0.25609756097561 4.1 4 1 increased systemic arterial blood pressure 0.760262853976673 1 0.61807470086827 0.25531914893617 4.1 4 1 abnormal limb morphology 0.806767012587764 1 0.613267453194851 0.253333333333333 4.1 4 1 abnormal CNS synaptic transmission 0.837048305631733 1 0.6113112571719 0.252525252525253 4.1 4 1 kidney cortex cysts 0.760174134243718 1 0.605198144600182 0.25 4.1 4 1 head bobbing 0.773956058955217 1 0.605198144600182 0.25 4.1 4 1 brain inflammation 0.738992768913638 1 0.605198144600182 0.25 4.1 4 1 abnormal dopamine level 0.738992768913638 1 0.605198144600182 0.25 4.1 4 1 abnormal long term potentiation 0.760174134243718 1 0.605198144600182 0.25 4.1 4 1 abnormal trachea morphology 0.738992768913638 1 0.605198144600182 0.25 4.1 4 1 decreased paired-pulse facilitation 0.738992768913638 1 0.605198144600182 0.25 4.1 4 1 prolonged QT interval 0.745920768204061 1 0.605198144600182 0.25 4.1 4 1 decreased ovulation rate 0.745920768204061 1 0.605198144600182 0.25 4.1 4 1 abnormal male reproductive system physiology 0.738992768913638 1 0.605198144600182 0.25 4.1 4 1 short radius 0.767158710825217 1 0.605198144600182 0.25 4.1 4 1 abnormal retinal ganglion layer morphology 0.745920768204061 1 0.605198144600182 0.25 4.1 4 1 decreased fatty acid level 0.745920768204061 1 0.605198144600182 0.25 4.1 4 1 abnormal phalanx morphology 0.786901942194458 1 0.605198144600182 0.25 4.1 4 1 abnormal cartilage development 0.806460888970365 1 0.5917492969424 0.244444444444444 4.1 4 1 abnormal autopod morphology 0.806460888970365 1 0.5917492969424 0.244444444444444 4.1 4 1 abnormal excitatory postsynaptic currents 0.858906711626688 1 0.589680243456587 0.243589743589744 4.1 4 1 abnormal middle ear morphology 0.787218609632971 1 0.584329243062244 0.241379310344828 4.1 4 1 abnormal spinal nerve morphology 0.787218609632971 1 0.584329243062244 0.241379310344828 4.1 4 1 aphagia 0.787218609632971 1 0.584329243062244 0.241379310344828 4.1 4 1 increased retinal apoptosis 0.787218609632971 1 0.584329243062244 0.241379310344828 4.1 4 1 abnormal energy expenditure 0.783120990866571 1 0.580990218816174 0.24 4.1 4 1 abnormal stomach mucosa morphology 0.783120990866571 1 0.580990218816174 0.24 4.1 4 1 decreased cochlear outer hair cell number 0.779921957769439 1 0.576379185333506 0.238095238095238 4.1 4 1 complete atrioventricular septal defect 0.779921957769439 1 0.576379185333506 0.238095238095238 4.1 4 1 syndactyly 0.859386914180285 1 0.574425357586613 0.23728813559322 4.1 4 1 abnormal retinal outer nuclear layer morphology 0.823199722466345 1 0.573345610673856 0.236842105263158 4.1 4 1 delayed eyelid opening 0.81769800310388 1 0.564851601626836 0.233333333333333 4.1 4 1 abnormal estrous cycle 0.81769800310388 1 0.564851601626836 0.233333333333333 4.1 4 1 abnormal pain threshold 0.81769800310388 1 0.564851601626836 0.233333333333333 4.1 4 1 abnormal xiphoid process morphology 0.816026052270604 1 0.558644441169398 0.230769230769231 4.1 4 1 abnormal kidney cortex morphology 0.816026052270604 1 0.558644441169398 0.230769230769231 4.1 4 1 abnormal ureter morphology 0.816026052270604 1 0.558644441169398 0.230769230769231 4.1 4 1 thick skin 0.816026052270604 1 0.558644441169398 0.230769230769231 4.1 4 1 no spontaneous movement 0.816026052270604 1 0.558644441169398 0.230769230769231 4.1 4 1 increased susceptibility to pharmacologically induced seizures 0.932745476774648 1 0.5547649658835 0.229166666666667 4.1 4 1 abnormal cranial ganglia morphology 0.844657707365927 1 0.546630582219519 0.225806451612903 4.1 4 1 abnormal trigeminal nerve morphology 0.844854324770685 1 0.537953906311272 0.222222222222222 4.1 4 1 abnormal long bone epiphyseal plate proliferative zone 0.903192088028469 1 0.537953906311272 0.222222222222222 4.1 4 1 abnormal digestive system physiology 0.902885645902877 1 0.53257436724816 0.22 4.1 4 1 increased dopamine level 0.868313107840146 1 0.529548376525159 0.21875 4.1 4 1 abnormal forelimb morphology 0.902954360782451 1 0.526259256174071 0.217391304347826 4.1 4 1 abnormal cochlear ganglion morphology 0.84664322338012 1 0.526259256174071 0.217391304347826 4.1 4 1 decreased food intake 0.952336002671767 1 0.520930048516612 0.215189873417722 4.1 4 1 abnormal cartilage morphology 0.903509039401998 1 0.518741266800156 0.214285714285714 4.1 4 1 increased circulating luteinizing hormone level 0.869889824684927 1 0.518741266800156 0.214285714285714 4.1 4 1 abnormal middle ear ossicle morphology 0.888914432016405 1 0.513501456024396 0.212121212121212 4.1 4 1 abnormal retinal photoreceptor morphology 0.9067311709926 1 0.498398472023679 0.205882352941176 4.1 4 1 hypertension 0.930462410866184 1 0.49516211830924 0.204545454545455 4.1 4 1 abnormal lactation 0.909895784988436 1 0.484158515680145 0.2 4.1 4 1 enhanced paired-pulse facilitation 0.909895784988436 1 0.484158515680145 0.2 4.1 4 1 abnormal diaphragm morphology 0.938762111874229 1 0.453898608450136 0.1875 4.1 4 1 abnormal cochlea morphology 0.974530336125281 1 0.44829492192606 0.185185185185185 4.1 4 1 decreased susceptibility to pharmacologically induced seizures 0.930470581892665 1 0.44829492192606 0.185185185185185 4.1 4 1 myoclonus 0.943640311720434 1 0.43228438900013 0.178571428571429 4.1 4 1 abnormal bone remodeling 0.959076846151768 1 0.42719869030601 0.176470588235294 4.1 4 1 impaired behavioral response to xenobiotic 0.966739753191634 1 0.414993013440124 0.171428571428571 4.1 4 1 short ulna 0.975529888138188 1 0.413306049970856 0.170731707317073 4.1 4 1 abnormal systemic arterial blood pressure 0.973065248657287 1 0.403465429733454 0.166666666666667 4.1 4 1 abnormal reflex 0.973065248657287 1 0.403465429733454 0.166666666666667 4.1 4 1 abnormal synaptic transmission 0.963435237844061 1 0.403465429733454 0.166666666666667 4.1 4 1 abnormal femur morphology 0.994927838370404 1 0.39744355764788 0.164179104477612 4.1 4 1 abnormal axon guidance 0.983823814044619 1 0.394082512762909 0.162790697674419 4.1 4 1 impaired skeletal muscle contractility 0.978262626139924 1 0.392560958659577 0.162162162162162 4.1 4 1 abnormal serotonin level 0.976638480938469 1 0.378248840375113 0.15625 4.1 4 1 abnormal inhibitory postsynaptic currents 0.998402951132742 1 0.355998908588342 0.147058823529412 4.1 4 1 increased osteosarcoma incidence 9.40454661373259e-06 0.000202543806940778 1.62285449203649 1 4.3 4 3 increased fibrosarcoma incidence 9.40454661373259e-06 0.000202543806940778 1.62285449203649 1 4.3 4 3 decreased transitional stage T2 B cell number 6.47623792305142e-05 0.00108848931308043 1.62285449203649 1 4.3 4 3 decreased macrophage cytokine production 6.47623792305142e-05 0.00108848931308043 1.62285449203649 1 4.3 4 3 increased neuronal precursor cell number 0.000169935480975078 0.00251615779122326 1.62285449203649 1 4.3 4 3 decreased transitional stage T1 B cell number 0.000169935480975078 0.00251615779122326 1.62285449203649 1 4.3 4 3 decreased activated T cell number 0.00116988782865621 0.0121217749219176 1.62285449203649 1 4.3 4 3 abnormal hypersensitivity reaction 0.00116988782865621 0.0121217749219176 1.62285449203649 1 4.3 4 3 decreased mortality induced by ionizing radiation 0.00116988782865621 0.0121217749219176 1.62285449203649 1 4.3 4 3 decreased DN2 thymocyte number 0.00116988782865621 0.0121217749219176 1.62285449203649 1 4.3 4 3 decreased brain cholesterol level 0.00116988782865621 0.0121217749219176 1.62285449203649 1 4.3 4 3 ductus venosus stenosis 0.00116988782865621 0.0121217749219176 1.62285449203649 1 4.3 4 3 liver cirrhosis 0.00306932668412448 0.0259692181182301 1.62285449203649 1 4.3 4 3 enlarged pancreas 0.00306932668412448 0.0259692181182301 1.62285449203649 1 4.3 4 3 abnormal immature B cell morphology 0.00306932668412448 0.0259692181182301 1.62285449203649 1 4.3 4 3 impaired granulocyte bactericidal activity 0.00306932668412448 0.0259692181182301 1.62285449203649 1 4.3 4 3 delayed chorioallantoic fusion 0.00306932668412448 0.0259692181182301 1.62285449203649 1 4.3 4 3 decreased macrophage nitric oxide production 0.00306932668412448 0.0259692181182301 1.62285449203649 1 4.3 4 3 thymus cortex atrophy 0.00306932668412448 0.0259692181182301 1.62285449203649 1 4.3 4 3 abnormal vertebral artery origin 0.00306932668412448 0.0259692181182301 1.62285449203649 1 4.3 4 3 absent ribs 0.00805232359802135 0.0557943034821117 1.62285449203649 1 4.3 4 3 abnormal pineal gland morphology 0.00805232359802135 0.0557943034821117 1.62285449203649 1 4.3 4 3 sinus inflammation 0.00805232359802135 0.0557943034821117 1.62285449203649 1 4.3 4 3 abnormal respiratory sounds 0.00805232359802135 0.0557943034821117 1.62285449203649 1 4.3 4 3 decreased lysosomal enzyme secretion 0.00805232359802135 0.0557943034821117 1.62285449203649 1 4.3 4 3 increased lysosomal enzyme secretion 0.00805232359802135 0.0557943034821117 1.62285449203649 1 4.3 4 3 abnormal inner cell mass proliferation 0.00805232359802135 0.0557943034821117 1.62285449203649 1 4.3 4 3 increased placenta apoptosis 0.00805232359802135 0.0557943034821117 1.62285449203649 1 4.3 4 3 abnormal mismatch repair 0.00805232359802135 0.0557943034821117 1.62285449203649 1 4.3 4 3 decreased DN3 thymocyte number 0.00805232359802135 0.0557943034821117 1.62285449203649 1 4.3 4 3 increased T follicular helper cell number 0.00805232359802135 0.0557943034821117 1.62285449203649 1 4.3 4 3 aorta hypoplasia 0.00805232359802135 0.0557943034821117 1.62285449203649 1 4.3 4 3 decreased heart left ventricle size 0.00805232359802135 0.0557943034821117 1.62285449203649 1 4.3 4 3 increased CD4-positive, alpha-beta memory T cell number 0.00805232359802135 0.0557943034821117 1.62285449203649 1 4.3 4 3 decreased pre-pro B cell number 0.00805232359802135 0.0557943034821117 1.62285449203649 1 4.3 4 3 decreased small intestinal villus height 0.00805232359802135 0.0557943034821117 1.62285449203649 1 4.3 4 3 decreased tumor incidence 1.0958099603424e-08 4.47593482234048e-07 1.62285449203649 1 4.3 4 3 elevated level of mitotic sister chromatid exchange 0.000445886722323283 0.00550443286242763 1.62285449203649 1 4.3 4 3 accumulation of giant lysosomes in kidney/renal tubule cells 0.000445886722323283 0.00550443286242763 1.62285449203649 1 4.3 4 3 abnormal mitotic spindle assembly checkpoint 0.000445886722323283 0.00550443286242763 1.62285449203649 1 4.3 4 3 pleural effusion 0.000445886722323283 0.00550443286242763 1.62285449203649 1 4.3 4 3 increased brain apoptosis 0.000445886722323283 0.00550443286242763 1.62285449203649 1 4.3 4 3 decreased B-1 B cell number 9.10554863932135e-14 8.23638263284068e-12 1.53963118475257 0.948717948717949 4.3 4 3 abnormal hypoglossal nerve topology 8.70175082592972e-07 2.3527831716848e-05 1.53269590914558 0.944444444444444 4.3 4 3 decreased B cell proliferation 1.93862983483517e-25 5.67334319312057e-23 1.52014218241393 0.936708860759494 4.3 4 3 increased B cell derived lymphoma incidence 1.85543993783032e-15 2.36687530530919e-13 1.49302613267357 0.92 4.3 4 3 increased hemangiosarcoma incidence 6.75829332851997e-08 2.30291159653335e-06 1.48761661770012 0.916666666666667 4.3 4 3 abnormal vascular endothelial cell development 0.000192706968734522 0.00277889034624419 1.48761661770012 0.916666666666667 4.3 4 3 abnormal B cell proliferation 0.000192706968734522 0.00277889034624419 1.48761661770012 0.916666666666667 4.3 4 3 persistent right dorsal aorta 0.000192706968734522 0.00277889034624419 1.48761661770012 0.916666666666667 4.3 4 3 abnormal B cell differentiation 2.92683594992801e-26 9.10063053180741e-24 1.48018596526405 0.912087912087912 4.3 4 3 abnormal dorsal-ventral polarity of the somites 0.000465588686964339 0.00566333427297698 1.47532226548772 0.909090909090909 4.3 4 3 reduced sympathetic cervical ganglion size 0.000465588686964339 0.00566333427297698 1.47532226548772 0.909090909090909 4.3 4 3 increased fibroblast apoptosis 8.8130022418311e-10 4.52007073743399e-08 1.47071188340807 0.90625 4.3 4 3 abnormal left subclavian artery morphology 0.00111649339667616 0.0118434001033345 1.46056904283284 0.9 4.3 4 3 abnormal inferior vena cava valve morphology 0.00111649339667616 0.0118434001033345 1.46056904283284 0.9 4.3 4 3 lethality during fetal growth through weaning, complete penetrance 0.00111649339667616 0.0118434001033345 1.46056904283284 0.9 4.3 4 3 increased cellular sensitivity to gamma-irradiation 3.72530419064078e-13 3.19541178421342e-11 1.45021039713899 0.893617021276596 4.3 4 3 abnormal Peyer's patch follicle morphology 1.2490611590739e-05 0.000254675379770191 1.44253732625466 0.888888888888889 4.3 4 3 decreased level of surface class I molecules 0.00265349665310892 0.0229985119324336 1.44253732625466 0.888888888888889 4.3 4 3 increased pheochromocytoma incidence 0.00265349665310892 0.0229985119324336 1.44253732625466 0.888888888888889 4.3 4 3 abnormal gut-associated lymphoid tissue morphology 0.00265349665310892 0.0229985119324336 1.44253732625466 0.888888888888889 4.3 4 3 abnormal thymus physiology 0.00265349665310892 0.0229985119324336 1.44253732625466 0.888888888888889 4.3 4 3 decreased cellular sensitivity to ionizing radiation 0.00265349665310892 0.0229985119324336 1.44253732625466 0.888888888888889 4.3 4 3 absent cervical lymph nodes 0.00265349665310892 0.0229985119324336 1.44253732625466 0.888888888888889 4.3 4 3 abnormal telomere morphology 0.00265349665310892 0.0229985119324336 1.44253732625466 0.888888888888889 4.3 4 3 abnormal infrahyoid muscle connection 0.00265349665310892 0.0229985119324336 1.44253732625466 0.888888888888889 4.3 4 3 decreased platelet dense granule number 0.00265349665310892 0.0229985119324336 1.44253732625466 0.888888888888889 4.3 4 3 increased thymocyte apoptosis 1.53820810976119e-07 4.78286584128871e-06 1.43560205064767 0.884615384615385 4.3 4 3 abnormal cell cycle 1.93289415740927e-28 7.39703725623932e-26 1.42528959735379 0.878260869565217 4.3 4 3 decreased liver cholesterol level 6.81294626771625e-05 0.00112981358939628 1.41999768053193 0.875 4.3 4 3 increased sensitivity to skin irradiation 0.00623789557298668 0.0461808489220368 1.41999768053193 0.875 4.3 4 3 colon polyps 0.00623789557298668 0.0461808489220368 1.41999768053193 0.875 4.3 4 3 abnormal NK cell morphology 0.00623789557298668 0.0461808489220368 1.41999768053193 0.875 4.3 4 3 craniofacial phenotype 0.00623789557298668 0.0461808489220368 1.41999768053193 0.875 4.3 4 3 abnormal epidermal lamellar body morphology 0.00623789557298668 0.0461808489220368 1.41999768053193 0.875 4.3 4 3 abnormal meiotic spindle morphology 0.00623789557298668 0.0461808489220368 1.41999768053193 0.875 4.3 4 3 abnormal base-excision repair 0.00623789557298668 0.0461808489220368 1.41999768053193 0.875 4.3 4 3 myocardial trabeculae hypoplasia 0.00623789557298668 0.0461808489220368 1.41999768053193 0.875 4.3 4 3 lung situs inversus 0.00623789557298668 0.0461808489220368 1.41999768053193 0.875 4.3 4 3 abnormal macrophage activation involved in immune response 0.00623789557298668 0.0461808489220368 1.41999768053193 0.875 4.3 4 3 embryo cyst 0.00623789557298668 0.0461808489220368 1.41999768053193 0.875 4.3 4 3 decreased vascular endothelial cell proliferation 0.00623789557298668 0.0461808489220368 1.41999768053193 0.875 4.3 4 3 abnormal T cell proliferation 2.4539897176226e-08 9.1793976279492e-07 1.41345391241888 0.870967741935484 4.3 4 3 abnormal lymphocyte physiology 9.92079288574044e-12 6.58079261420782e-10 1.41117781916217 0.869565217391304 4.3 4 3 increased mortality induced by gamma-irradiation 1.28612599747448e-07 4.10158771630484e-06 1.39901249313491 0.862068965517241 4.3 4 3 subcutaneous edema 2.92252477982481e-07 8.40437039284879e-06 1.39101813603128 0.857142857142857 4.3 4 3 abnormal spleen periarteriolar lymphoid sheath morphology 0.000360279942546055 0.0045958787542734 1.39101813603128 0.857142857142857 4.3 4 3 increased hemangioma incidence 0.000360279942546055 0.0045958787542734 1.39101813603128 0.857142857142857 4.3 4 3 vascular smooth muscle hypoplasia 0.000360279942546055 0.0045958787542734 1.39101813603128 0.857142857142857 4.3 4 3 increased B-1 B cell number 0.000360279942546055 0.0045958787542734 1.39101813603128 0.857142857142857 4.3 4 3 lysosomal protein accumulation 0.000360279942546055 0.0045958787542734 1.39101813603128 0.857142857142857 4.3 4 3 testis degeneration 0.000360279942546055 0.0045958787542734 1.39101813603128 0.857142857142857 4.3 4 3 abnormal vitelline vein topology 0.000360279942546055 0.0045958787542734 1.39101813603128 0.857142857142857 4.3 4 3 decreased response to antigen 0.000360279942546055 0.0045958787542734 1.39101813603128 0.857142857142857 4.3 4 3 cellular necrosis 0.0144659598169341 0.089624097246883 1.39101813603128 0.857142857142857 4.3 4 3 broad head 0.0144659598169341 0.089624097246883 1.39101813603128 0.857142857142857 4.3 4 3 skin photosensitivity 0.0144659598169341 0.089624097246883 1.39101813603128 0.857142857142857 4.3 4 3 abnormal circulating alanine transaminase level 0.0144659598169341 0.089624097246883 1.39101813603128 0.857142857142857 4.3 4 3 abnormal tumor incidence 0.0144659598169341 0.089624097246883 1.39101813603128 0.857142857142857 4.3 4 3 decreased cardiomyocyte apoptosis 0.0144659598169341 0.089624097246883 1.39101813603128 0.857142857142857 4.3 4 3 increased cell nucleus count 0.0144659598169341 0.089624097246883 1.39101813603128 0.857142857142857 4.3 4 3 abnormal MHC II cell surface expression on macrophages 0.0144659598169341 0.089624097246883 1.39101813603128 0.857142857142857 4.3 4 3 heart hemorrhage 0.0144659598169341 0.089624097246883 1.39101813603128 0.857142857142857 4.3 4 3 increased tumor latency 0.0144659598169341 0.089624097246883 1.39101813603128 0.857142857142857 4.3 4 3 abnormal sperm annulus morphology 0.0144659598169341 0.089624097246883 1.39101813603128 0.857142857142857 4.3 4 3 arteritis 0.0144659598169341 0.089624097246883 1.39101813603128 0.857142857142857 4.3 4 3 decreased T-helper 17 cell number 0.0144659598169341 0.089624097246883 1.39101813603128 0.857142857142857 4.3 4 3 abnormal aortic valve cusp morphology 0.0144659598169341 0.089624097246883 1.39101813603128 0.857142857142857 4.3 4 3 increased right ventricle systolic pressure 0.0144659598169341 0.089624097246883 1.39101813603128 0.857142857142857 4.3 4 3 embryonic lethality at implantation, incomplete penetrance 0.0144659598169341 0.089624097246883 1.39101813603128 0.857142857142857 4.3 4 3 absent connection between subcutaneous lymph vessels and lymph sac 0.0144659598169341 0.089624097246883 1.39101813603128 0.857142857142857 4.3 4 3 increased mammary adenocarcinoma incidence 2.26547436069756e-05 0.000431828925075493 1.37942631823102 0.85 4.3 4 3 spleen atrophy 2.26547436069756e-05 0.000431828925075493 1.37942631823102 0.85 4.3 4 3 abnormal telomere length 0.00081668491041926 0.00913035377378835 1.37318457018472 0.846153846153846 4.3 4 3 absent hypoglossal nerve 0.00081668491041926 0.00913035377378835 1.37318457018472 0.846153846153846 4.3 4 3 abnormal chromosome morphology 1.50616345298326e-08 5.94695490364421e-07 1.35968889873328 0.837837837837838 4.3 4 3 abnormal lysosome morphology 3.32725395105815e-08 1.20825462821272e-06 1.35237874336374 0.833333333333333 4.3 4 3 absent inner cell mass 0.000113175276113987 0.00173245230359102 1.35237874336374 0.833333333333333 4.3 4 3 increased effector memory CD4-positive, alpha-beta T cell number 0.000113175276113987 0.00173245230359102 1.35237874336374 0.833333333333333 4.3 4 3 increased effector memory CD8-positive, alpha-beta T cell number 0.000113175276113987 0.00173245230359102 1.35237874336374 0.833333333333333 4.3 4 3 abnormal thymus involution 0.00182999727811342 0.0173414027783129 1.35237874336374 0.833333333333333 4.3 4 3 altered tumor susceptibility 0.00182999727811342 0.0173414027783129 1.35237874336374 0.833333333333333 4.3 4 3 abnormal defecation 0.00182999727811342 0.0173414027783129 1.35237874336374 0.833333333333333 4.3 4 3 pale placenta 0.00182999727811342 0.0173414027783129 1.35237874336374 0.833333333333333 4.3 4 3 abnormal fatty acid level 0.00182999727811342 0.0173414027783129 1.35237874336374 0.833333333333333 4.3 4 3 decreased red blood cell distribution width 0.00182999727811342 0.0173414027783129 1.35237874336374 0.833333333333333 4.3 4 3 abnormal pulmonary valve cusp morphology 0.00182999727811342 0.0173414027783129 1.35237874336374 0.833333333333333 4.3 4 3 abnormal vitelline vein connection 0.00182999727811342 0.0173414027783129 1.35237874336374 0.833333333333333 4.3 4 3 epidermal necrosis 0.0329673081675058 0.168217803213683 1.35237874336374 0.833333333333333 4.3 4 3 absent ectoplacental cone 0.0329673081675058 0.168217803213683 1.35237874336374 0.833333333333333 4.3 4 3 non-obstructive hydrocephaly 0.0329673081675058 0.168217803213683 1.35237874336374 0.833333333333333 4.3 4 3 abnormal lymph organ size 0.0329673081675058 0.168217803213683 1.35237874336374 0.833333333333333 4.3 4 3 abnormal lymph node cortex morphology 0.0329673081675058 0.168217803213683 1.35237874336374 0.833333333333333 4.3 4 3 abnormal cervical lymph node morphology 0.0329673081675058 0.168217803213683 1.35237874336374 0.833333333333333 4.3 4 3 abnormal hippocampal fimbria morphology 0.0329673081675058 0.168217803213683 1.35237874336374 0.833333333333333 4.3 4 3 ectopic thymus 0.0329673081675058 0.168217803213683 1.35237874336374 0.833333333333333 4.3 4 3 decreased posterior semicircular canal size 0.0329673081675058 0.168217803213683 1.35237874336374 0.833333333333333 4.3 4 3 calcified joint 0.0329673081675058 0.168217803213683 1.35237874336374 0.833333333333333 4.3 4 3 extremity edema 0.0329673081675058 0.168217803213683 1.35237874336374 0.833333333333333 4.3 4 3 decreased liver function 0.0329673081675058 0.168217803213683 1.35237874336374 0.833333333333333 4.3 4 3 abnormal cholesterol level 0.0329673081675058 0.168217803213683 1.35237874336374 0.833333333333333 4.3 4 3 osteomyelitis 0.0329673081675058 0.168217803213683 1.35237874336374 0.833333333333333 4.3 4 3 decreased platelet ADP level 0.0329673081675058 0.168217803213683 1.35237874336374 0.833333333333333 4.3 4 3 absent brachial lymph nodes 0.0329673081675058 0.168217803213683 1.35237874336374 0.833333333333333 4.3 4 3 increased transitional stage T1 B cell number 0.0329673081675058 0.168217803213683 1.35237874336374 0.833333333333333 4.3 4 3 visceral vascular congestion 0.0329673081675058 0.168217803213683 1.35237874336374 0.833333333333333 4.3 4 3 abnormal oval cell physiology 0.0329673081675058 0.168217803213683 1.35237874336374 0.833333333333333 4.3 4 3 kidney microaneurysm 0.0329673081675058 0.168217803213683 1.35237874336374 0.833333333333333 4.3 4 3 myocardium hypoplasia 0.0329673081675058 0.168217803213683 1.35237874336374 0.833333333333333 4.3 4 3 cerebral arteriovenous malformation 0.0329673081675058 0.168217803213683 1.35237874336374 0.833333333333333 4.3 4 3 thick pulmonary valve cusps 0.0329673081675058 0.168217803213683 1.35237874336374 0.833333333333333 4.3 4 3 absent third pharyngeal arch 0.0329673081675058 0.168217803213683 1.35237874336374 0.833333333333333 4.3 4 3 abnormal ureteric bud tip morphology 0.0329673081675058 0.168217803213683 1.35237874336374 0.833333333333333 4.3 4 3 abnormal endocrine pancreas development 0.0329673081675058 0.168217803213683 1.35237874336374 0.833333333333333 4.3 4 3 delayed limb development 0.0329673081675058 0.168217803213683 1.35237874336374 0.833333333333333 4.3 4 3 decreased tear production 0.0329673081675058 0.168217803213683 1.35237874336374 0.833333333333333 4.3 4 3 decreased capillary density 0.0329673081675058 0.168217803213683 1.35237874336374 0.833333333333333 4.3 4 3 increased B cell proliferation 1.70088330257624e-12 1.322171004737e-10 1.34779440864048 0.830508474576271 4.3 4 3 abnormal cell nucleus morphology 3.47968291140357e-10 1.90235411914646e-08 1.34662394020049 0.829787234042553 4.3 4 3 abnormal erythropoiesis 5.20038802252441e-21 1.12486653965474e-18 1.34465086483024 0.828571428571429 4.3 4 3 abnormal B cell morphology 1.61689518711862e-05 0.0003204802213512 1.34061892820406 0.826086956521739 4.3 4 3 abnormal hematopoietic stem cell physiology 1.61689518711862e-05 0.0003204802213512 1.34061892820406 0.826086956521739 4.3 4 3 increased lung adenocarcinoma incidence 1.15738994300309e-10 6.67405825201177e-09 1.33646840520652 0.823529411764706 4.3 4 3 abnormal dorsal-ventral axis patterning 0.000249467139784614 0.00348623320345071 1.33646840520652 0.823529411764706 4.3 4 3 abnormal ectoplacental cone morphology 0.000249467139784614 0.00348623320345071 1.33646840520652 0.823529411764706 4.3 4 3 embryonic lethality before implantation, incomplete penetrance 3.52982340338622e-05 0.000640907716490745 1.32779003893895 0.818181818181818 4.3 4 3 abnormal thrombopoiesis 0.00404556459037934 0.0328867382959759 1.32779003893895 0.818181818181818 4.3 4 3 delayed hepatic development 0.00404556459037934 0.0328867382959759 1.32779003893895 0.818181818181818 4.3 4 3 abnormal food preference 0.00404556459037934 0.0328867382959759 1.32779003893895 0.818181818181818 4.3 4 3 abnormal proximal-distal axis patterning 0.00404556459037934 0.0328867382959759 1.32779003893895 0.818181818181818 4.3 4 3 vasculitis 0.00404556459037934 0.0328867382959759 1.32779003893895 0.818181818181818 4.3 4 3 increased number of Howell-Jolly bodies 0.00404556459037934 0.0328867382959759 1.32779003893895 0.818181818181818 4.3 4 3 thin hypoglossal nerve 0.00404556459037934 0.0328867382959759 1.32779003893895 0.818181818181818 4.3 4 3 increased tumor incidence 4.85174701748375e-23 1.34096896733232e-20 1.32184115883618 0.814516129032258 4.3 4 3 disorganized yolk sac vascular plexus 0.000544005784584093 0.00642857191996641 1.31856927477965 0.8125 4.3 4 3 intraventricular hemorrhage 0.000544005784584093 0.00642857191996641 1.31856927477965 0.8125 4.3 4 3 increased intestinal adenocarcinoma incidence 0.000544005784584093 0.00642857191996641 1.31856927477965 0.8125 4.3 4 3 abnormal level of surface class II molecules 0.000544005784584093 0.00642857191996641 1.31856927477965 0.8125 4.3 4 3 decreased fibroblast apoptosis 0.000544005784584093 0.00642857191996641 1.31856927477965 0.8125 4.3 4 3 increased incidence of induced tumors 7.6376505198088e-05 0.00125403667775739 1.31373935069621 0.80952380952381 4.3 4 3 increased leukemia incidence 1.09957828626022e-05 0.000231796693819686 1.31076708972178 0.807692307692308 4.3 4 3 increased embryonic tissue cell apoptosis 1.4695037402746e-14 1.55548534209918e-12 1.31076708972178 0.807692307692308 4.3 4 3 abnormal cell morphology 1.41245778418615e-20 2.92790728180253e-18 1.30967204620489 0.807017543859649 4.3 4 3 inner cell mass degeneration 1.60919925844454e-06 4.05442032015154e-05 1.30875362261007 0.806451612903226 4.3 4 3 impaired hematopoiesis 8.06935773004542e-10 4.22579523231326e-08 1.30464772889208 0.803921568627451 4.3 4 3 abnormal embryo turning 2.59269348377887e-10 1.44928652604493e-08 1.29828359362919 0.8 4.3 4 3 abnormal thymocyte activation 0.000163650455403312 0.00243760783123197 1.29828359362919 0.8 4.3 4 3 abnormal immune cell physiology 0.00880150967883999 0.0599828913044232 1.29828359362919 0.8 4.3 4 3 abnormal gas homeostasis 0.00880150967883999 0.0599828913044232 1.29828359362919 0.8 4.3 4 3 absent inguinal lymph nodes 0.00880150967883999 0.0599828913044232 1.29828359362919 0.8 4.3 4 3 increased circulating fructosamine level 0.00880150967883999 0.0599828913044232 1.29828359362919 0.8 4.3 4 3 acanthocytosis 0.00880150967883999 0.0599828913044232 1.29828359362919 0.8 4.3 4 3 thick aortic valve cusps 0.00880150967883999 0.0599828913044232 1.29828359362919 0.8 4.3 4 3 decreased trabecular bone connectivity density 0.00880150967883999 0.0599828913044232 1.29828359362919 0.8 4.3 4 3 decreased macrophage apoptosis 0.00880150967883999 0.0599828913044232 1.29828359362919 0.8 4.3 4 3 increased pre-B cell number 2.34798611887522e-05 0.000442470868992584 1.29828359362919 0.8 4.3 4 3 abnormal lymph node B cell domain morphology 0.00117197462059143 0.0121217749219176 1.29828359362919 0.8 4.3 4 3 delayed intramembranous bone ossification 0.00117197462059143 0.0121217749219176 1.29828359362919 0.8 4.3 4 3 abnormal trophectoderm morphology 0.00117197462059143 0.0121217749219176 1.29828359362919 0.8 4.3 4 3 immune system phenotype 0.00117197462059143 0.0121217749219176 1.29828359362919 0.8 4.3 4 3 abnormal dendritic cell morphology 0.00117197462059143 0.0121217749219176 1.29828359362919 0.8 4.3 4 3 heterochrony 0.00117197462059143 0.0121217749219176 1.29828359362919 0.8 4.3 4 3 abnormal apoptosis 5.47069537782883e-10 2.92652790373102e-08 1.29227302143647 0.796296296296296 4.3 4 3 increased T cell derived lymphoma incidence 3.6111350413308e-09 1.60405328844828e-07 1.29165969774333 0.795918367346939 4.3 4 3 abnormal spleen red pulp morphology 1.07045573962138e-06 2.84787021637239e-05 1.28873739073486 0.794117647058823 4.3 4 3 abnormal direction of heart looping 1.07045573962138e-06 2.84787021637239e-05 1.28873739073486 0.794117647058823 4.3 4 3 abnormal embryonic erythropoiesis 7.24830727190753e-06 0.000160983610168482 1.28709149368412 0.793103448275862 4.3 4 3 embryonic lethality between implantation and somite formation, complete penetrance 1.40607026519763e-39 8.74399946169773e-37 1.28503580185747 0.791836734693877 4.3 4 3 increased malignant tumor incidence 0.000346880489168026 0.00451761893615426 1.28120091476565 0.789473684210526 4.3 4 3 abnormal placenta vasculature 2.40261172061046e-09 1.12764087830538e-07 1.27955834949031 0.788461538461538 4.3 4 3 increased double-negative T cell number 1.16249659696754e-10 6.67405825201177e-09 1.27700025602872 0.786885245901639 4.3 4 3 spleen hyperplasia 8.7155222122822e-13 6.99350371066192e-11 1.27664553373537 0.786666666666667 4.3 4 3 premature aging 1.52016706149684e-05 0.000303728157869348 1.27509995802867 0.785714285714286 4.3 4 3 abnormal vascular endothelial cell migration 0.00249016979262102 0.0226897339162812 1.27509995802867 0.785714285714286 4.3 4 3 abnormal maternal decidual layer morphology 0.00249016979262102 0.0226897339162812 1.27509995802867 0.785714285714286 4.3 4 3 increased stomach tumor incidence 0.00249016979262102 0.0226897339162812 1.27509995802867 0.785714285714286 4.3 4 3 multiple persisting craniopharyngeal ducts 0.00249016979262102 0.0226897339162812 1.27509995802867 0.785714285714286 4.3 4 3 increased T cell proliferation 1.62687868436748e-17 2.52928795460257e-15 1.2740166105707 0.785046728971963 4.3 4 3 embryonic lethality before implantation, complete penetrance 4.02555572851858e-20 7.41745916643701e-18 1.27231792175661 0.784 4.3 4 3 decreased cell proliferation 4.62376832840945e-29 1.91693728615308e-26 1.27196703429887 0.783783783783784 4.3 4 3 pale liver 1.80824630714178e-12 1.38400390431236e-10 1.27196703429887 0.783783783783784 4.3 4 3 decreased IgM level 6.79262593074779e-16 9.38703166818618e-14 1.27151485973993 0.783505154639175 4.3 4 3 abnormal neural tube closure 8.89284903661989e-14 8.19294888095999e-12 1.27091014436593 0.783132530120482 4.3 4 3 abnormal cell death 3.29243366411995e-08 1.20440128522035e-06 1.27006003724595 0.782608695652174 4.3 4 3 failure to gastrulate 3.29243366411995e-08 1.20440128522035e-06 1.27006003724595 0.782608695652174 4.3 4 3 embryonic lethality between implantation and placentation, complete penetrance 3.29243366411995e-08 1.20440128522035e-06 1.27006003724595 0.782608695652174 4.3 4 3 abnormal embryonic hematopoiesis 4.67755576312417e-06 0.000105297918197026 1.26785507190351 0.78125 4.3 4 3 abnormal humoral immune response 6.95769870119763e-17 1.01807503054289e-14 1.26737207949517 0.780952380952381 4.3 4 3 arrested B cell differentiation 2.17683824104251e-07 6.64403082772176e-06 1.26661814012604 0.780487804878049 4.3 4 3 abnormal megakaryocyte differentiation 0.000726488662631804 0.00823298655260416 1.26222016047283 0.777777777777778 4.3 4 3 abnormal thymus cortex morphology 0.000726488662631804 0.00823298655260416 1.26222016047283 0.777777777777778 4.3 4 3 abnormal bile duct morphology 0.000726488662631804 0.00823298655260416 1.26222016047283 0.777777777777778 4.3 4 3 abnormal redox activity 0.000726488662631804 0.00823298655260416 1.26222016047283 0.777777777777778 4.3 4 3 abnormal neutrophil morphology 0.000726488662631804 0.00823298655260416 1.26222016047283 0.777777777777778 4.3 4 3 primary atelectasis 0.000726488662631804 0.00823298655260416 1.26222016047283 0.777777777777778 4.3 4 3 abnormal aerobic respiration 0.000726488662631804 0.00823298655260416 1.26222016047283 0.777777777777778 4.3 4 3 crypts of Lieberkuhn abscesses 0.0187832917925588 0.111378875647175 1.26222016047283 0.777777777777778 4.3 4 3 abnormal posterior semicircular canal morphology 0.0187832917925588 0.111378875647175 1.26222016047283 0.777777777777778 4.3 4 3 premature neuronal precursor differentiation 0.0187832917925588 0.111378875647175 1.26222016047283 0.777777777777778 4.3 4 3 decreased susceptibility to atherosclerosis 0.0187832917925588 0.111378875647175 1.26222016047283 0.777777777777778 4.3 4 3 abnormal leukopoiesis 0.0187832917925588 0.111378875647175 1.26222016047283 0.777777777777778 4.3 4 3 abnormal liver vasculature morphology 0.0187832917925588 0.111378875647175 1.26222016047283 0.777777777777778 4.3 4 3 eye opacity 0.0187832917925588 0.111378875647175 1.26222016047283 0.777777777777778 4.3 4 3 abnormal ventricle myocardium morphology 0.0187832917925588 0.111378875647175 1.26222016047283 0.777777777777778 4.3 4 3 shortened ST segment 0.0187832917925588 0.111378875647175 1.26222016047283 0.777777777777778 4.3 4 3 decreased effector memory CD4-positive, alpha-beta T cell number 0.0187832917925588 0.111378875647175 1.26222016047283 0.777777777777778 4.3 4 3 increased myeloid cell number 0.0187832917925588 0.111378875647175 1.26222016047283 0.777777777777778 4.3 4 3 abnormal ductus venosus valve topology 0.0187832917925588 0.111378875647175 1.26222016047283 0.777777777777778 4.3 4 3 symmetric azygos veins 0.0187832917925588 0.111378875647175 1.26222016047283 0.777777777777778 4.3 4 3 increased cardiac muscle glycogen level 0.0187832917925588 0.111378875647175 1.26222016047283 0.777777777777778 4.3 4 3 increased sarcoma incidence 2.13067039254012e-08 8.03036757794476e-07 1.25854021831402 0.775510204081633 4.3 4 3 autoimmune response 9.66464519284479e-06 0.000206358840490999 1.25640347770567 0.774193548387097 4.3 4 3 decreased thymus weight 9.66464519284479e-06 0.000206358840490999 1.25640347770567 0.774193548387097 4.3 4 3 abnormal myelopoiesis 1.39744536086336e-07 4.40018396854126e-06 1.25402392566456 0.772727272727273 4.3 4 3 intestinal inflammation 0.000216042627156456 0.00306214264986714 1.25402392566456 0.772727272727273 4.3 4 3 abnormal lysosome physiology 0.000216042627156456 0.00306214264986714 1.25402392566456 0.772727272727273 4.3 4 3 decreased B cell number 2.46604532631922e-30 1.22685754984381e-27 1.2525915739505 0.771844660194175 4.3 4 3 embryonic lethality between somite formation and embryo turning, complete penetrance 3.22846693982596e-11 1.9829164229178e-09 1.25191632242815 0.771428571428571 4.3 4 3 increased carcinoma incidence 2.97333528386799e-06 7.0105891171769e-05 1.25191632242815 0.771428571428571 4.3 4 3 abnormal midbrain development 2.97333528386799e-06 7.0105891171769e-05 1.25191632242815 0.771428571428571 4.3 4 3 vertebral transformation 4.36294761972608e-08 1.55040460058123e-06 1.25095033761146 0.770833333333333 4.3 4 3 decreased T cell proliferation 5.00876942808568e-22 1.18660132879649e-19 1.25003656819027 0.77027027027027 4.3 4 3 decreased double-positive T cell number 2.51091691305023e-15 2.97424086724402e-13 1.2495979588681 0.77 4.3 4 3 abnormal leukocyte migration 1.36529067974606e-08 5.47767833204567e-07 1.24834960925884 0.769230769230769 4.3 4 3 increased foot pad pigmentation 0.00520770517042728 0.0401057789827797 1.24834960925884 0.769230769230769 4.3 4 3 abnormal grip strength 0.00520770517042728 0.0401057789827797 1.24834960925884 0.769230769230769 4.3 4 3 abnormal tail bud morphology 0.00520770517042728 0.0401057789827797 1.24834960925884 0.769230769230769 4.3 4 3 abnormal exocrine pancreas morphology 0.00520770517042728 0.0401057789827797 1.24834960925884 0.769230769230769 4.3 4 3 abnormal double-strand DNA break repair 2.85271147052984e-07 8.29955530168768e-06 1.24544647063266 0.767441860465116 4.3 4 3 decreased bone marrow cell number 2.07474843118485e-11 1.32331710835188e-09 1.24492947334306 0.767123287671233 4.3 4 3 abnormal spleen marginal zone morphology 1.98001838532932e-05 0.000387818561693439 1.24418844389464 0.766666666666667 4.3 4 3 abnormal interatrial septum morphology 0.0015012563801824 0.0147834596920358 1.2410063762632 0.764705882352941 4.3 4 3 abnormal embryonic-extraembryonic boundary morphology 0.0015012563801824 0.0147834596920358 1.2410063762632 0.764705882352941 4.3 4 3 pancytopenia 0.0015012563801824 0.0147834596920358 1.2410063762632 0.764705882352941 4.3 4 3 extramedullary hematopoiesis 1.04029759073595e-15 1.36196855629246e-13 1.24010579108449 0.764150943396226 4.3 4 3 abnormal definitive hematopoiesis 6.58037203059603e-14 6.17685865136136e-12 1.2389534294042 0.763440860215054 4.3 4 3 increased bone marrow cell number 1.86920415146874e-06 4.58093135643201e-05 1.2384942176068 0.763157894736842 4.3 4 3 preweaning lethality, complete penetrance 6.89061194323547e-101 3.42807944175964e-97 1.23687828852511 0.762162162162162 4.3 4 3 abnormal erythrocyte physiology 0.000442927096060026 0.00550443286242763 1.23646056536114 0.761904761904762 4.3 4 3 absent segment of posterior cerebral artery 0.000442927096060026 0.00550443286242763 1.23646056536114 0.761904761904762 4.3 4 3 abnormal preimplantation embryo development 0.000132706282966571 0.00201900231730486 1.23336941394773 0.76 4.3 4 3 embryonic lethality, complete penetrance 3.83358775943939e-43 2.724585586173e-40 1.23113099395872 0.758620689655172 4.3 4 3 abnormal embryonic neuroepithelium morphology 5.47916484737348e-09 2.32981582185325e-07 1.23113099395872 0.758620689655172 4.3 4 3 decreased trophoblast giant cell number 4.01979554074453e-05 0.000706660170148553 1.23113099395872 0.758620689655172 4.3 4 3 abnormal CD8-positive, alpha-beta T cell physiology 4.01979554074453e-05 0.000706660170148553 1.23113099395872 0.758620689655172 4.3 4 3 blood in lymph vessels 4.01979554074453e-05 0.000706660170148553 1.23113099395872 0.758620689655172 4.3 4 3 increased cardiomyocyte apoptosis 1.22762014066617e-05 0.000251333753078773 1.22943522123977 0.757575757575758 4.3 4 3 increased hepatocellular carcinoma incidence 1.09761617753877e-08 4.47593482234048e-07 1.22425865188718 0.754385964912281 4.3 4 3 lymphoid hyperplasia 8.08157083541304e-05 0.00130963566469641 1.21714086902737 0.75 4.3 4 3 abnormal mitotic spindle morphology 8.08157083541304e-05 0.00130963566469641 1.21714086902737 0.75 4.3 4 3 increased T cell number 2.10840400973953e-12 1.56556864902301e-10 1.21714086902737 0.75 4.3 4 3 pericardial edema 6.75633746797975e-10 3.57582754289354e-08 1.21714086902737 0.75 4.3 4 3 liver hypoplasia 6.99678028805377e-08 2.35195823872078e-06 1.21714086902737 0.75 4.3 4 3 thymus atrophy 2.24404471279291e-07 6.8073917354541e-06 1.21714086902737 0.75 4.3 4 3 abnormal cellular extravasation 0.000267571992031696 0.00367726701756267 1.21714086902737 0.75 4.3 4 3 abnormal vascular regression 0.000896570590462166 0.00976981741576608 1.21714086902737 0.75 4.3 4 3 decreased myocardial infarction size 0.000896570590462166 0.00976981741576608 1.21714086902737 0.75 4.3 4 3 increased skin tumor incidence 0.000896570590462166 0.00976981741576608 1.21714086902737 0.75 4.3 4 3 absent ductus venosus valve 0.000896570590462166 0.00976981741576608 1.21714086902737 0.75 4.3 4 3 failure of tooth eruption 0.00305588112861346 0.0259692181182301 1.21714086902737 0.75 4.3 4 3 large intestinal inflammation 0.00305588112861346 0.0259692181182301 1.21714086902737 0.75 4.3 4 3 blepharitis 0.00305588112861346 0.0259692181182301 1.21714086902737 0.75 4.3 4 3 myocarditis 0.0106922665271771 0.0714013771445717 1.21714086902737 0.75 4.3 4 3 interstitial pneumonia 0.0106922665271771 0.0714013771445717 1.21714086902737 0.75 4.3 4 3 increased papilloma incidence 0.0106922665271771 0.0714013771445717 1.21714086902737 0.75 4.3 4 3 small intestinal inflammation 0.0106922665271771 0.0714013771445717 1.21714086902737 0.75 4.3 4 3 abnormal rostral-caudal body axis extension 0.0106922665271771 0.0714013771445717 1.21714086902737 0.75 4.3 4 3 embryonic lethality between implantation and placentation, incomplete penetrance 0.0106922665271771 0.0714013771445717 1.21714086902737 0.75 4.3 4 3 abnormal exoccipital bone morphology 0.0391501525487764 0.191401578263823 1.21714086902737 0.75 4.3 4 3 dry eyes 0.0391501525487764 0.191401578263823 1.21714086902737 0.75 4.3 4 3 abnormal cellular cholesterol metabolism 0.0391501525487764 0.191401578263823 1.21714086902737 0.75 4.3 4 3 abnormal umbilical artery morphology 0.0391501525487764 0.191401578263823 1.21714086902737 0.75 4.3 4 3 increased cardiac output 0.0391501525487764 0.191401578263823 1.21714086902737 0.75 4.3 4 3 binucleate 0.0391501525487764 0.191401578263823 1.21714086902737 0.75 4.3 4 3 tau protein deposits 0.0391501525487764 0.191401578263823 1.21714086902737 0.75 4.3 4 3 abnormal extraembryonic tissue physiology 0.0391501525487764 0.191401578263823 1.21714086902737 0.75 4.3 4 3 abnormal lateral ganglionic eminence morphology 0.0391501525487764 0.191401578263823 1.21714086902737 0.75 4.3 4 3 abnormal kidney epithelium morphology 0.0391501525487764 0.191401578263823 1.21714086902737 0.75 4.3 4 3 abnormal choroid pigmentation 0.0391501525487764 0.191401578263823 1.21714086902737 0.75 4.3 4 3 abnormal somite size 0.0391501525487764 0.191401578263823 1.21714086902737 0.75 4.3 4 3 abnormal olfactory bulb mitral cell layer morphology 0.0391501525487764 0.191401578263823 1.21714086902737 0.75 4.3 4 3 decreased hippocampus pyramidal cell number 0.0391501525487764 0.191401578263823 1.21714086902737 0.75 4.3 4 3 abnormal cerebellum deep nucleus morphology 0.0391501525487764 0.191401578263823 1.21714086902737 0.75 4.3 4 3 abnormal hepatic vein morphology 0.0391501525487764 0.191401578263823 1.21714086902737 0.75 4.3 4 3 abnormal visual evoked potential 0.0391501525487764 0.191401578263823 1.21714086902737 0.75 4.3 4 3 decreased alveolar lamellar body number 0.0391501525487764 0.191401578263823 1.21714086902737 0.75 4.3 4 3 lethality during fetal growth through weaning, incomplete penetrance 0.0391501525487764 0.191401578263823 1.21714086902737 0.75 4.3 4 3 decreased cranium length 0.0391501525487764 0.191401578263823 1.21714086902737 0.75 4.3 4 3 small thymus medulla 0.0391501525487764 0.191401578263823 1.21714086902737 0.75 4.3 4 3 absent hypoglossal canal 0.0391501525487764 0.191401578263823 1.21714086902737 0.75 4.3 4 3 increased mammary gland apoptosis 0.0391501525487764 0.191401578263823 1.21714086902737 0.75 4.3 4 3 abnormal dendritic cell physiology 1.32649658418317e-14 1.43463489267637e-12 1.21334915292448 0.747663551401869 4.3 4 3 decreased embryo size 1.93899124661822e-59 3.21549381730855e-56 1.20865313632843 0.744769874476987 4.3 4 3 abnormal vasculogenesis 1.43174156392502e-06 3.67160529924072e-05 1.20770566849227 0.744186046511628 4.3 4 3 small liver 8.24784274110867e-11 4.94373706470068e-09 1.20673795561688 0.743589743589744 4.3 4 3 increased autoantibody level 4.62428770505193e-06 0.000104571960602879 1.20673795561688 0.743589743589744 4.3 4 3 failure of heart looping 4.62428770505193e-06 0.000104571960602879 1.20673795561688 0.743589743589744 4.3 4 3 abnormal embryo size 5.17834576316194e-15 5.99122562133271e-13 1.20636971089438 0.743362831858407 4.3 4 3 increased lung adenoma incidence 4.89398575020818e-05 0.000857309123495975 1.20405333280127 0.741935483870968 4.3 4 3 increased brain weight 0.00016077424292209 0.00240195753314533 1.20211443854555 0.740740740740741 4.3 4 3 abnormal eye muscle morphology 0.00016077424292209 0.00240195753314533 1.20211443854555 0.740740740740741 4.3 4 3 decreased IgG level 1.98702586193856e-14 2.05946951315507e-12 1.19886548060354 0.738738738738739 4.3 4 3 small superior vagus ganglion 0.0017893915483304 0.0172523700638444 1.19578752044794 0.736842105263158 4.3 4 3 increased liver adenoma incidence 0.0017893915483304 0.0172523700638444 1.19578752044794 0.736842105263158 4.3 4 3 abnormal blastocyst morphology 0.0017893915483304 0.0172523700638444 1.19578752044794 0.736842105263158 4.3 4 3 increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 0.0017893915483304 0.0172523700638444 1.19578752044794 0.736842105263158 4.3 4 3 enlarged spleen 1.26729065032794e-34 7.00530109486832e-32 1.19460122330464 0.736111111111111 4.3 4 3 arrested T cell differentiation 9.62918271813641e-05 0.00152564280327161 1.19009329416009 0.733333333333333 4.3 4 3 liver hemorrhage 9.62918271813641e-05 0.00152564280327161 1.19009329416009 0.733333333333333 4.3 4 3 abnormal optic cup morphology 9.62918271813641e-05 0.00152564280327161 1.19009329416009 0.733333333333333 4.3 4 3 abnormal brain vasculature morphology 9.62918271813641e-05 0.00152564280327161 1.19009329416009 0.733333333333333 4.3 4 3 macrocytosis 0.00611520651570237 0.0460956854782111 1.19009329416009 0.733333333333333 4.3 4 3 abnormal placenta size 0.00611520651570237 0.0460956854782111 1.19009329416009 0.733333333333333 4.3 4 3 decreased thymocyte apoptosis 0.00611520651570237 0.0460956854782111 1.19009329416009 0.733333333333333 4.3 4 3 liver vascular congestion 0.00611520651570237 0.0460956854782111 1.19009329416009 0.733333333333333 4.3 4 3 abnormal microglial cell activation 0.00611520651570237 0.0460956854782111 1.19009329416009 0.733333333333333 4.3 4 3 abnormal CD4-positive, alpha-beta T cell physiology 1.94849708608833e-09 9.41143010028103e-08 1.18856948712532 0.732394366197183 4.3 4 3 decreased IgA level 3.25148730689013e-07 9.29663755849333e-06 1.1859321287959 0.730769230769231 4.3 4 3 decreased bone resorption 0.000316226814365007 0.00414158283875567 1.1859321287959 0.730769230769231 4.3 4 3 decreased Peyer's patch number 0.000316226814365007 0.00414158283875567 1.1859321287959 0.730769230769231 4.3 4 3 abnormal T cell activation 1.19249810002083e-09 5.93267804760362e-08 1.18424516986447 0.72972972972973 4.3 4 3 embryonic growth arrest 8.49973866977179e-27 2.81907999214098e-24 1.18347904004408 0.729257641921397 4.3 4 3 embryonic lethality during organogenesis, complete penetrance 1.95813750330995e-63 4.87086703948349e-60 1.18236541562659 0.728571428571429 4.3 4 3 abnormal abdominal fat pad morphology 0.00104795234646955 0.0112119632767441 1.18025781239018 0.727272727272727 4.3 4 3 increased activated T cell number 0.00104795234646955 0.0112119632767441 1.18025781239018 0.727272727272727 4.3 4 3 abnormal occipital bone morphology 0.00104795234646955 0.0112119632767441 1.18025781239018 0.727272727272727 4.3 4 3 increased mammary gland tumor incidence 0.00104795234646955 0.0112119632767441 1.18025781239018 0.727272727272727 4.3 4 3 increased adenoma incidence 0.00104795234646955 0.0112119632767441 1.18025781239018 0.727272727272727 4.3 4 3 abnormal sphenoid bone morphology 0.021484029914735 0.120363793722755 1.18025781239018 0.727272727272727 4.3 4 3 impaired myelopoiesis 0.021484029914735 0.120363793722755 1.18025781239018 0.727272727272727 4.3 4 3 loss of cortex neurons 0.021484029914735 0.120363793722755 1.18025781239018 0.727272727272727 4.3 4 3 increased glycogen level 0.021484029914735 0.120363793722755 1.18025781239018 0.727272727272727 4.3 4 3 decreased embryonic cilium length 0.021484029914735 0.120363793722755 1.18025781239018 0.727272727272727 4.3 4 3 abnormal skeleton physiology 5.755847901626e-05 0.000990842329086137 1.18025781239018 0.727272727272727 4.3 4 3 myeloid hyperplasia 5.755847901626e-05 0.000990842329086137 1.18025781239018 0.727272727272727 4.3 4 3 pallor 1.99722100285709e-20 3.97446979568562e-18 1.17772868850648 0.725714285714286 4.3 4 3 thymus hypoplasia 2.53294505462327e-16 3.60040047050022e-14 1.17598151596847 0.72463768115942 4.3 4 3 decreased granulocyte number 0.000187437309839179 0.00273357864635292 1.17517049423332 0.724137931034483 4.3 4 3 pale yolk sac 2.70770407315276e-10 1.49675864043722e-08 1.17314782556855 0.72289156626506 4.3 4 3 abnormal forebrain development 4.40870762203175e-09 1.89080348444896e-07 1.17206157758191 0.722222222222222 4.3 4 3 abnormal pharyngeal arch morphology 3.43648863050003e-05 0.000626246554459255 1.17206157758191 0.722222222222222 4.3 4 3 abnormal trophoblast giant cell morphology 3.43648863050003e-05 0.000626246554459255 1.17206157758191 0.722222222222222 4.3 4 3 underdeveloped hair follicles 0.00351565244581393 0.0292481119028835 1.17206157758191 0.722222222222222 4.3 4 3 decreased cellular sensitivity to gamma-irradiation 0.00351565244581393 0.0292481119028835 1.17206157758191 0.722222222222222 4.3 4 3 increased gastrointestinal tumor incidence 0.00351565244581393 0.0292481119028835 1.17206157758191 0.722222222222222 4.3 4 3 abnormal macrophage chemotaxis 0.00351565244581393 0.0292481119028835 1.17206157758191 0.722222222222222 4.3 4 3 impaired leukocyte tethering or rolling 0.00351565244581393 0.0292481119028835 1.17206157758191 0.722222222222222 4.3 4 3 abnormal NK cell physiology 7.24420499835414e-08 2.40266132445412e-06 1.17058356802632 0.721311475409836 4.3 4 3 abnormal cytokine secretion 1.13549037602304e-17 1.88302154023821e-15 1.16971979620812 0.720779220779221 4.3 4 3 increased monocyte cell number 6.21600213279967e-12 4.35557895925047e-10 1.16845523426627 0.72 4.3 4 3 mandible hypoplasia 0.000614369529627733 0.00717485542229571 1.16845523426627 0.72 4.3 4 3 increased cellular sensitivity to ionizing radiation 0.000614369529627733 0.00717485542229571 1.16845523426627 0.72 4.3 4 3 increased fatty acid level 0.000111075492220052 0.00171615085029429 1.16642666615123 0.71875 4.3 4 3 abnormal spleen morphology 1.62333840060944e-19 2.88432447965427e-17 1.16584374427909 0.718390804597701 4.3 4 3 increased hepatocyte apoptosis 2.05031915638128e-05 0.000400013247176347 1.16512630197492 0.717948717948718 4.3 4 3 abnormal immune system morphology 3.83769525693446e-06 8.92174481460232e-05 1.16422170080879 0.717391304347826 4.3 4 3 abnormal allantois morphology 3.83769525693446e-06 8.92174481460232e-05 1.16422170080879 0.717391304347826 4.3 4 3 increased spleen weight 4.4817934235684e-13 3.77913936987336e-11 1.16328507836244 0.716814159292035 4.3 4 3 intracranial hemorrhage 1.38160473574997e-07 4.37801500659623e-06 1.16304571929282 0.716666666666667 4.3 4 3 abnormal extraembryonic tissue morphology 7.17582383348862e-12 4.95829494050082e-10 1.1614546854771 0.715686274509804 4.3 4 3 anemia 5.40572976464178e-23 1.34797458179213e-20 1.16137928103086 0.71563981042654 4.3 4 3 decreased leukocyte cell number 2.03005122687102e-15 2.49742750094594e-13 1.16087401620129 0.715328467153285 4.3 4 3 abnormal ventral body wall morphology 0.012001543614943 0.0790830191845579 1.15918178002607 0.714285714285714 4.3 4 3 failure of zygotic cell division 0.012001543614943 0.0790830191845579 1.15918178002607 0.714285714285714 4.3 4 3 absent olfactory bulb 0.012001543614943 0.0790830191845579 1.15918178002607 0.714285714285714 4.3 4 3 split sternum 0.012001543614943 0.0790830191845579 1.15918178002607 0.714285714285714 4.3 4 3 spina bifida occulta 0.012001543614943 0.0790830191845579 1.15918178002607 0.714285714285714 4.3 4 3 asymmetric rib joints 0.0792206790439349 0.303144373344414 1.15918178002607 0.714285714285714 4.3 4 3 polyphalangy 0.0792206790439349 0.303144373344414 1.15918178002607 0.714285714285714 4.3 4 3 maxilla hypoplasia 0.0792206790439349 0.303144373344414 1.15918178002607 0.714285714285714 4.3 4 3 mammary gland hyperplasia 0.0792206790439349 0.303144373344414 1.15918178002607 0.714285714285714 4.3 4 3 retina hyperplasia 0.0792206790439349 0.303144373344414 1.15918178002607 0.714285714285714 4.3 4 3 abnormal lacrimal gland morphology 0.0792206790439349 0.303144373344414 1.15918178002607 0.714285714285714 4.3 4 3 abnormal axial mesoderm 0.0792206790439349 0.303144373344414 1.15918178002607 0.714285714285714 4.3 4 3 abnormal gastrulation movements 0.0792206790439349 0.303144373344414 1.15918178002607 0.714285714285714 4.3 4 3 abnormal brain ventricular system morphology 0.0792206790439349 0.303144373344414 1.15918178002607 0.714285714285714 4.3 4 3 abnormal lymph node primary follicle morphology 0.0792206790439349 0.303144373344414 1.15918178002607 0.714285714285714 4.3 4 3 abnormal sinus venosus morphology 0.0792206790439349 0.303144373344414 1.15918178002607 0.714285714285714 4.3 4 3 aorta coarctation 0.0792206790439349 0.303144373344414 1.15918178002607 0.714285714285714 4.3 4 3 increased chronic myelocytic leukemia incidence 0.0792206790439349 0.303144373344414 1.15918178002607 0.714285714285714 4.3 4 3 decreased tidal volume 0.0792206790439349 0.303144373344414 1.15918178002607 0.714285714285714 4.3 4 3 absent popliteal lymph nodes 0.0792206790439349 0.303144373344414 1.15918178002607 0.714285714285714 4.3 4 3 abnormal uterus physiology 0.0792206790439349 0.303144373344414 1.15918178002607 0.714285714285714 4.3 4 3 abnormal spinal cord central canal morphology 0.0792206790439349 0.303144373344414 1.15918178002607 0.714285714285714 4.3 4 3 decreased DN4 thymocyte number 0.0792206790439349 0.303144373344414 1.15918178002607 0.714285714285714 4.3 4 3 coronary fistula 0.0792206790439349 0.303144373344414 1.15918178002607 0.714285714285714 4.3 4 3 long stride length 0.0792206790439349 0.303144373344414 1.15918178002607 0.714285714285714 4.3 4 3 altered tumor pathology 0.0792206790439349 0.303144373344414 1.15918178002607 0.714285714285714 4.3 4 3 small tail bud 0.0792206790439349 0.303144373344414 1.15918178002607 0.714285714285714 4.3 4 3 embryo tumor 0.0792206790439349 0.303144373344414 1.15918178002607 0.714285714285714 4.3 4 3 increased grip strength 1.15248602310726e-10 6.67405825201177e-09 1.15918178002607 0.714285714285714 4.3 4 3 abnormal liver development 6.58335585657908e-05 0.00110076504074761 1.15918178002607 0.714285714285714 4.3 4 3 spleen hypoplasia 4.35404709990779e-12 3.18549769441783e-10 1.15918178002607 0.714285714285714 4.3 4 3 abnormal spleen white pulp morphology 1.22283755894775e-05 0.000251333753078773 1.15918178002607 0.714285714285714 4.3 4 3 abnormal cytotoxic T cell physiology 1.22283755894775e-05 0.000251333753078773 1.15918178002607 0.714285714285714 4.3 4 3 abnormal hematopoietic system physiology 0.0020306793264675 0.0190975985806726 1.15918178002607 0.714285714285714 4.3 4 3 abnormal T cell differentiation 1.35618484079857e-11 8.87765734601696e-10 1.15688637056067 0.712871287128713 4.3 4 3 distended pericardium 1.37656459166443e-06 3.56687960600549e-05 1.15472338856443 0.711538461538462 4.3 4 3 kinked neural tube 1.37656459166443e-06 3.56687960600549e-05 1.15472338856443 0.711538461538462 4.3 4 3 oxidative stress 2.17436191998092e-10 1.22925574453467e-08 1.15402986100373 0.711111111111111 4.3 4 3 lethality throughout fetal growth and development, complete penetrance 2.93498585302564e-20 5.61598254569328e-18 1.15308082328909 0.710526315789474 4.3 4 3 incomplete somite formation 3.90331061072674e-05 0.00069602044044321 1.15308082328909 0.710526315789474 4.3 4 3 abnormal CD8-positive, alpha beta T cell morphology 0.000212041086397386 0.00303276622689311 1.15170318789687 0.709677419354839 4.3 4 3 abnormal mitochondrial ATP synthesis coupled electron transport 0.000212041086397386 0.00303276622689311 1.15170318789687 0.709677419354839 4.3 4 3 abnormal somite development 3.49956023627595e-09 1.56849659238494e-07 1.1503778677727 0.708860759493671 4.3 4 3 small heart 4.34833728669292e-06 0.000100152675931932 1.14952193185918 0.708333333333333 4.3 4 3 abnormal nursing 0.00117772423516134 0.0121308034574072 1.14952193185918 0.708333333333333 4.3 4 3 abnormal inner cell mass apoptosis 0.00117772423516134 0.0121308034574072 1.14952193185918 0.708333333333333 4.3 4 3 abnormal cell differentiation 2.31538833360435e-05 0.000437986956641887 1.14787268948923 0.707317073170732 4.3 4 3 increased brain size 0.00678698052484798 0.0498012214028299 1.14554434731988 0.705882352941177 4.3 4 3 increased hepatoma incidence 0.00678698052484798 0.0498012214028299 1.14554434731988 0.705882352941177 4.3 4 3 neurodegeneration 1.54668884803633e-06 3.94603949691321e-05 1.14200871661827 0.703703703703704 4.3 4 3 abnormal atrioventricular cushion morphology 0.000685426671541936 0.00791182758914416 1.14200871661827 0.703703703703704 4.3 4 3 abnormal trigeminal ganglion morphology 0.000685426671541936 0.00791182758914416 1.14200871661827 0.703703703703704 4.3 4 3 decreased circulating fructosamine level 0.000685426671541936 0.00791182758914416 1.14200871661827 0.703703703703704 4.3 4 3 decreased bone ossification 0.000685426671541936 0.00791182758914416 1.14200871661827 0.703703703703704 4.3 4 3 incomplete embryo turning 9.22683087187789e-07 2.48126938311311e-05 1.13884525756947 0.701754385964912 4.3 4 3 increased metastatic potential 0.000400110102707413 0.00503936142017565 1.13599814442555 0.7 4.3 4 3 abnormal Peyer's patch T cell area morphology 0.00387264045002293 0.0318452665105192 1.13599814442555 0.7 4.3 4 3 abnormal sperm mitochondrial sheath morphology 0.00387264045002293 0.0318452665105192 1.13599814442555 0.7 4.3 4 3 retarded hair growth 0.0420741167245695 0.197284383322086 1.13599814442555 0.7 4.3 4 3 enlarged testis 0.0420741167245695 0.197284383322086 1.13599814442555 0.7 4.3 4 3 abnormal mammary gland physiology 0.0420741167245695 0.197284383322086 1.13599814442555 0.7 4.3 4 3 abnormal airway responsiveness 0.0420741167245695 0.197284383322086 1.13599814442555 0.7 4.3 4 3 bifid ureter 0.0420741167245695 0.197284383322086 1.13599814442555 0.7 4.3 4 3 absent CD4-positive, alpha beta T cells 0.0420741167245695 0.197284383322086 1.13599814442555 0.7 4.3 4 3 abnormal submandibular gland morphology 0.0420741167245695 0.197284383322086 1.13599814442555 0.7 4.3 4 3 abnormal plasma membrane morphology 0.0420741167245695 0.197284383322086 1.13599814442555 0.7 4.3 4 3 abnormal embryonic erythrocyte morphology 0.0420741167245695 0.197284383322086 1.13599814442555 0.7 4.3 4 3 abnormal deltoid tuberosity morphology 0.0420741167245695 0.197284383322086 1.13599814442555 0.7 4.3 4 3 abnormal corneal endothelium morphology 0.0420741167245695 0.197284383322086 1.13599814442555 0.7 4.3 4 3 osteosclerosis 0.0420741167245695 0.197284383322086 1.13599814442555 0.7 4.3 4 3 tachypnea 0.0420741167245695 0.197284383322086 1.13599814442555 0.7 4.3 4 3 increased platelet aggregation 0.0420741167245695 0.197284383322086 1.13599814442555 0.7 4.3 4 3 absent axillary lymph nodes 0.0420741167245695 0.197284383322086 1.13599814442555 0.7 4.3 4 3 abnormal cerebellar granule cell migration 0.0420741167245695 0.197284383322086 1.13599814442555 0.7 4.3 4 3 abnormal vibrissa follicle morphology 0.0420741167245695 0.197284383322086 1.13599814442555 0.7 4.3 4 3 thin ventricle myocardium compact layer 0.0420741167245695 0.197284383322086 1.13599814442555 0.7 4.3 4 3 seminiferous tubule degeneration 3.78540920065588e-08 1.3548496959182e-06 1.13377505608029 0.698630136986301 4.3 4 3 abnormal vascular development 1.96137544894238e-07 6.060771961794e-06 1.13108040354059 0.696969696969697 4.3 4 3 decreased brown adipose tissue amount 0.000234164622588776 0.00330019545999763 1.13108040354059 0.696969696969697 4.3 4 3 abnormal T cell subpopulation ratio 0.000234164622588776 0.00330019545999763 1.13108040354059 0.696969696969697 4.3 4 3 abnormal placenta morphology 1.35602372327254e-08 5.47767833204567e-07 1.12983540584819 0.69620253164557 4.3 4 3 abnormal vitelline vasculature morphology 7.84976230204819e-12 5.27737398009321e-10 1.12894225532973 0.695652173913043 4.3 4 3 abnormal cardiovascular development 0.00222491070881252 0.0206895902361538 1.12894225532973 0.695652173913043 4.3 4 3 abnormal Wolffian duct morphology 0.00222491070881252 0.0206895902361538 1.12894225532973 0.695652173913043 4.3 4 3 decreased effector memory CD8-positive, alpha-beta T cell number 0.00222491070881252 0.0206895902361538 1.12894225532973 0.695652173913043 4.3 4 3 abnormal vertebral artery topology 0.00222491070881252 0.0206895902361538 1.12894225532973 0.695652173913043 4.3 4 3 decreased lymphocyte cell number 5.5700691770866e-13 4.61851569266764e-11 1.12839101399412 0.6953125 4.3 4 3 hydrops fetalis 6.99399808025188e-08 2.35195823872078e-06 1.12698228613645 0.694444444444444 4.3 4 3 absent common myeloid progenitor cells 0.0230325295798641 0.126895719446095 1.12351464833296 0.692307692307692 4.3 4 3 lymphoid hypoplasia 0.0230325295798641 0.126895719446095 1.12351464833296 0.692307692307692 4.3 4 3 abnormal pulmonary alveolus epithelial cell morphology 0.0230325295798641 0.126895719446095 1.12351464833296 0.692307692307692 4.3 4 3 abnormal coping response 0.0230325295798641 0.126895719446095 1.12351464833296 0.692307692307692 4.3 4 3 small pituitary gland 0.0230325295798641 0.126895719446095 1.12351464833296 0.692307692307692 4.3 4 3 orthokeratosis 0.0230325295798641 0.126895719446095 1.12351464833296 0.692307692307692 4.3 4 3 empty decidua capsularis 0.0230325295798641 0.126895719446095 1.12351464833296 0.692307692307692 4.3 4 3 increased neuron apoptosis 1.4917185690941e-08 5.93703990499451e-07 1.12197347597585 0.691358024691358 4.3 4 3 increased leukocyte cell number 4.80265637238907e-14 4.59484912550685e-12 1.11920999450793 0.689655172413793 4.3 4 3 decreased T cell number 2.058181458066e-15 2.49742750094594e-13 1.11886241376429 0.68944099378882 4.3 4 3 trabecula carnea hypoplasia 2.80233754064163e-05 0.000518276180843573 1.11796642784736 0.688888888888889 4.3 4 3 abnormal cell migration 2.80233754064163e-05 0.000518276180843573 1.11796642784736 0.688888888888889 4.3 4 3 small placenta 2.80233754064163e-05 0.000518276180843573 1.11796642784736 0.688888888888889 4.3 4 3 abnormal osteoclast physiology 6.62841943408139e-07 1.83202148247527e-05 1.11571246327509 0.6875 4.3 4 3 abnormal molar crown morphology 0.012845722367298 0.0840887747069835 1.11571246327509 0.6875 4.3 4 3 impaired somite development 0.012845722367298 0.0840887747069835 1.11571246327509 0.6875 4.3 4 3 embryonic lethality between somite formation and embryo turning, incomplete penetrance 0.012845722367298 0.0840887747069835 1.11571246327509 0.6875 4.3 4 3 failure of chorioallantoic fusion 9.78158440720247e-06 0.000207963172759967 1.11372367100544 0.686274509803922 4.3 4 3 abnormal embryonic epiblast morphology 0.000253574181452548 0.00351401546720453 1.11281450882502 0.685714285714286 4.3 4 3 decreased bone mineralization 0.000253574181452548 0.00351401546720453 1.11281450882502 0.685714285714286 4.3 4 3 decreased hair follicle number 0.000148483488776457 0.00225215047763071 1.11037412613023 0.684210526315789 4.3 4 3 enlarged adrenal glands 0.00725588439036162 0.0523159780319551 1.11037412613023 0.684210526315789 4.3 4 3 altered susceptibility to infection 0.00725588439036162 0.0523159780319551 1.11037412613023 0.684210526315789 4.3 4 3 oliguria 0.00725588439036162 0.0523159780319551 1.11037412613023 0.684210526315789 4.3 4 3 abnormal embryo development 8.00737745414523e-13 6.53060702202828e-11 1.10974608646613 0.683823529411765 4.3 4 3 increased B cell number 3.13545184045508e-11 1.949859113283e-09 1.10964409711897 0.683760683760684 4.3 4 3 increased erythrocyte cell number 2.0333438365352e-06 4.95876744449147e-05 1.10895056955827 0.683333333333333 4.3 4 3 muscular atrophy 5.12387026906209e-05 0.000894429985564347 1.10649169911579 0.681818181818182 4.3 4 3 increased skin papilloma incidence 0.00413652285503454 0.0331922600061239 1.10649169911579 0.681818181818182 4.3 4 3 abnormal vascular branching morphogenesis 0.00413652285503454 0.0331922600061239 1.10649169911579 0.681818181818182 4.3 4 3 abnormal mesenteric lymph node morphology 0.00413652285503454 0.0331922600061239 1.10649169911579 0.681818181818182 4.3 4 3 decreased susceptibility to viral infection induced morbidity/mortality 0.00413652285503454 0.0331922600061239 1.10649169911579 0.681818181818182 4.3 4 3 abnormal sperm midpiece morphology 0.00413652285503454 0.0331922600061239 1.10649169911579 0.681818181818182 4.3 4 3 impaired humoral immune response 0.00413652285503454 0.0331922600061239 1.10649169911579 0.681818181818182 4.3 4 3 decreased erythrocyte cell number 2.22635553832337e-14 2.26043240880791e-12 1.10602185126054 0.681528662420382 4.3 4 3 microcephaly 4.25809125105145e-07 1.19683638271079e-05 1.10542262501036 0.681159420289855 4.3 4 3 increased lymphocyte cell number 4.25809125105145e-07 1.19683638271079e-05 1.10542262501036 0.681159420289855 4.3 4 3 abnormal T-helper 1 physiology 3.01796570523857e-05 0.000554036139614829 1.104922207344 0.680851063829787 4.3 4 3 abnormal inflammatory response 2.53195115273144e-07 7.49789106240412e-06 1.10444264041372 0.680555555555556 4.3 4 3 ruffled hair 0.00237485298442027 0.021879432587946 1.10354105458482 0.68 4.3 4 3 spontaneous skin ulceration 0.00237485298442027 0.021879432587946 1.10354105458482 0.68 4.3 4 3 decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 0.00237485298442027 0.021879432587946 1.10354105458482 0.68 4.3 4 3 abnormal somite shape 0.00137102286618627 0.013863493413164 1.10122269102476 0.678571428571429 4.3 4 3 abnormal spleen germinal center morphology 0.00137102286618627 0.013863493413164 1.10122269102476 0.678571428571429 4.3 4 3 increased bone resorption 0.00137102286618627 0.013863493413164 1.10122269102476 0.678571428571429 4.3 4 3 hypoxia 0.00137102286618627 0.013863493413164 1.10122269102476 0.678571428571429 4.3 4 3 osteopetrosis 0.000795055036958466 0.00892866548277284 1.09935304299246 0.67741935483871 4.3 4 3 pale kidney 0.000795055036958466 0.00892866548277284 1.09935304299246 0.67741935483871 4.3 4 3 decreased mean corpuscular hemoglobin 7.67911172516321e-07 2.09909784794983e-05 1.09781333284822 0.676470588235294 4.3 4 3 enlarged liver sinusoidal spaces 0.000462757165311252 0.00565655257352205 1.09781333284822 0.676470588235294 4.3 4 3 increased granulocyte number 2.71103195259358e-07 7.93375527303121e-06 1.09652330543006 0.675675675675676 4.3 4 3 abnormal respiratory electron transport chain 0.000270180108675446 0.00369014799946477 1.09652330543006 0.675675675675676 4.3 4 3 anophthalmia 2.02733766630678e-08 7.69924037395132e-07 1.09405920811449 0.674157303370786 4.3 4 3 abnormal T-helper 2 physiology 1.11885065329611e-05 0.000233877394964207 1.09173847646091 0.672727272727273 4.3 4 3 decreased circulating total protein level 1.11885065329611e-05 0.000233877394964207 1.09173847646091 0.672727272727273 4.3 4 3 prenatal lethality, complete penetrance 5.41899329363671e-23 1.34797458179213e-20 1.09163233816843 0.672661870503597 4.3 4 3 abnormal spermiogenesis 6.61546798019164e-06 0.000147587234087235 1.09122974464523 0.672413793103448 4.3 4 3 thrombocytosis 6.61546798019164e-06 0.000147587234087235 1.09122974464523 0.672413793103448 4.3 4 3 internal hemorrhage 1.37579559538148e-06 3.56687960600549e-05 1.08997689763645 0.671641791044776 4.3 4 3 thrombocytopenia 2.02412096524694e-12 1.52575784880357e-10 1.08563369467269 0.668965517241379 4.3 4 3 impaired natural killer cell mediated cytotoxicity 1.1796662400526e-05 0.000244534981010903 1.081902994691 0.666666666666667 4.3 4 3 abnormal thymus medulla morphology 0.013329636682916 0.0859306394049962 1.081902994691 0.666666666666667 4.3 4 3 long tibia 0.013329636682916 0.0859306394049962 1.081902994691 0.666666666666667 4.3 4 3 decreased lactate dehydrogenase level 0.013329636682916 0.0859306394049962 1.081902994691 0.666666666666667 4.3 4 3 decreased tumor latency 0.013329636682916 0.0859306394049962 1.081902994691 0.666666666666667 4.3 4 3 heart hyperplasia 0.0798838740612113 0.303144373344414 1.081902994691 0.666666666666667 4.3 4 3 distorted hair follicle pattern 0.0798838740612113 0.303144373344414 1.081902994691 0.666666666666667 4.3 4 3 dilated uterus 0.0798838740612113 0.303144373344414 1.081902994691 0.666666666666667 4.3 4 3 abnormal kindling response 0.0798838740612113 0.303144373344414 1.081902994691 0.666666666666667 4.3 4 3 multifocal hepatic necrosis 0.0798838740612113 0.303144373344414 1.081902994691 0.666666666666667 4.3 4 3 abnormal germ cell morphology 0.0798838740612113 0.303144373344414 1.081902994691 0.666666666666667 4.3 4 3 abnormal thymus lobule morphology 0.0798838740612113 0.303144373344414 1.081902994691 0.666666666666667 4.3 4 3 abnormal artery development 0.0798838740612113 0.303144373344414 1.081902994691 0.666666666666667 4.3 4 3 decreased susceptibility to induced choroidal neovascularization 0.0798838740612113 0.303144373344414 1.081902994691 0.666666666666667 4.3 4 3 decreased fear-related response 0.0798838740612113 0.303144373344414 1.081902994691 0.666666666666667 4.3 4 3 decreased vestibular hair cell number 0.0798838740612113 0.303144373344414 1.081902994691 0.666666666666667 4.3 4 3 short frontal bone 0.0798838740612113 0.303144373344414 1.081902994691 0.666666666666667 4.3 4 3 liver hyperplasia 0.0798838740612113 0.303144373344414 1.081902994691 0.666666666666667 4.3 4 3 abnormal pulmonary alveolar system morphology 0.0798838740612113 0.303144373344414 1.081902994691 0.666666666666667 4.3 4 3 abnormal oxidative phosphorylation 0.0798838740612113 0.303144373344414 1.081902994691 0.666666666666667 4.3 4 3 abnormal lung lobe morphology 0.0798838740612113 0.303144373344414 1.081902994691 0.666666666666667 4.3 4 3 increased core body temperature 0.0798838740612113 0.303144373344414 1.081902994691 0.666666666666667 4.3 4 3 trigeminal neuroma 0.0798838740612113 0.303144373344414 1.081902994691 0.666666666666667 4.3 4 3 abnormal coronary sinus connection 0.0798838740612113 0.303144373344414 1.081902994691 0.666666666666667 4.3 4 3 increased endoplasmic reticulum stress 0.0798838740612113 0.303144373344414 1.081902994691 0.666666666666667 4.3 4 3 abnormal myocardial trabeculae morphology 9.7669357259029e-05 0.00154255572178943 1.081902994691 0.666666666666667 4.3 4 3 abnormal leukocyte adhesion 0.000283999638669287 0.00384985886207003 1.081902994691 0.666666666666667 4.3 4 3 gastrointestinal hemorrhage 0.0014366799959632 0.0143523754616806 1.081902994691 0.666666666666667 4.3 4 3 salivary gland inflammation 0.0014366799959632 0.0143523754616806 1.081902994691 0.666666666666667 4.3 4 3 abnormal microglial cell physiology 0.0014366799959632 0.0143523754616806 1.081902994691 0.666666666666667 4.3 4 3 abnormal fetal cardiomyocyte proliferation 0.00248471857382273 0.0226897339162812 1.081902994691 0.666666666666667 4.3 4 3 hemolytic anemia 0.00431928365611484 0.0344745300077606 1.081902994691 0.666666666666667 4.3 4 3 abnormal tumor morphology 0.00431928365611484 0.0344745300077606 1.081902994691 0.666666666666667 4.3 4 3 decreased hepatocyte number 0.0237742178134241 0.129109689417104 1.081902994691 0.666666666666667 4.3 4 3 absent egg cylinders 0.0237742178134241 0.129109689417104 1.081902994691 0.666666666666667 4.3 4 3 increased airway responsiveness 0.0237742178134241 0.129109689417104 1.081902994691 0.666666666666667 4.3 4 3 decreased brown adipose tissue mass 0.0237742178134241 0.129109689417104 1.081902994691 0.666666666666667 4.3 4 3 abnormal supraoccipital bone morphology 0.0430675566898509 0.199312646076287 1.081902994691 0.666666666666667 4.3 4 3 abnormal embryonic growth/weight/body size 0.0430675566898509 0.199312646076287 1.081902994691 0.666666666666667 4.3 4 3 increased growth rate 0.0430675566898509 0.199312646076287 1.081902994691 0.666666666666667 4.3 4 3 abnormal thymus corticomedullary boundary morphology 0.0430675566898509 0.199312646076287 1.081902994691 0.666666666666667 4.3 4 3 decreased mammary gland epithelial cell proliferation 0.0430675566898509 0.199312646076287 1.081902994691 0.666666666666667 4.3 4 3 prenatal growth retardation 0.0430675566898509 0.199312646076287 1.081902994691 0.666666666666667 4.3 4 3 abnormal eye pigmentation 0.00755656269713376 0.0539367280032144 1.081902994691 0.666666666666667 4.3 4 3 liver degeneration 0.00755656269713376 0.0539367280032144 1.081902994691 0.666666666666667 4.3 4 3 left pulmonary isomerism 0.00755656269713376 0.0539367280032144 1.081902994691 0.666666666666667 4.3 4 3 increased acute inflammation 0.00755656269713376 0.0539367280032144 1.081902994691 0.666666666666667 4.3 4 3 embryonic lethality at implantation, complete penetrance 0.00755656269713376 0.0539367280032144 1.081902994691 0.666666666666667 4.3 4 3 hemorrhage 1.3836175474853e-18 2.37361975818599e-16 1.0772991521604 0.663829787234043 4.3 4 3 pericardial effusion 7.30187603182281e-06 0.000161452592259193 1.07317797054026 0.661290322580645 4.3 4 3 increased bone mineral content 3.17624195085541e-09 1.43652760959142e-07 1.07197727914337 0.660550458715596 4.3 4 3 decreased oocyte number 5.99231248504339e-05 0.00102445892141206 1.07108396474409 0.66 4.3 4 3 increased respiratory quotient 0.000101768947145971 0.00160221681028862 1.0703933883645 0.659574468085106 4.3 4 3 small spleen 7.04427232228307e-08 2.35203052371532e-06 1.07001395079329 0.659340659340659 4.3 4 3 lethality throughout fetal growth and development, incomplete penetrance 4.29893688842299e-14 4.19357078821654e-12 1.06981469307434 0.659217877094972 4.3 4 3 osteoporosis 0.000173134911662158 0.00255592339916688 1.0696086424786 0.659090909090909 4.3 4 3 abnormal developmental patterning 3.33454284737425e-07 9.47962895182109e-06 1.06870905573135 0.658536585365854 4.3 4 3 Leydig cell hyperplasia 0.000295126312001667 0.0039682524384008 1.06870905573135 0.658536585365854 4.3 4 3 increased bone trabecula number 0.000295126312001667 0.0039682524384008 1.06870905573135 0.658536585365854 4.3 4 3 abnormal response to infection 5.60441558855985e-07 1.55765181860811e-05 1.06820802007465 0.658227848101266 4.3 4 3 decreased birth body size 1.98016154310917e-09 9.47240738170011e-08 1.06766742897138 0.657894736842105 4.3 4 3 decreased neuron apoptosis 0.00050421207001966 0.00610329695461754 1.06766742897138 0.657894736842105 4.3 4 3 abnormal spermatogenesis 2.68893208944964e-14 2.6754874290024e-12 1.06720322574139 0.657608695652174 4.3 4 3 increased circulating serum albumin level 0.000863691217707101 0.00954858624020628 1.06644723762398 0.657142857142857 4.3 4 3 increased sacral vertebrae number 7.58841000903681e-06 0.000167045751305125 1.06499826039895 0.65625 4.3 4 3 scoliosis 0.001484026174303 0.0147660604343149 1.06499826039895 0.65625 4.3 4 3 abnormal spongiotrophoblast layer morphology 0.001484026174303 0.0147660604343149 1.06499826039895 0.65625 4.3 4 3 lordosis 0.00255926285106741 0.0229985119324336 1.06324949478253 0.655172413793103 4.3 4 3 increased double-positive T cell number 0.00255926285106741 0.0229985119324336 1.06324949478253 0.655172413793103 4.3 4 3 polychromatophilia 0.00255926285106741 0.0229985119324336 1.06324949478253 0.655172413793103 4.3 4 3 abnormal platelet physiology 3.66035447677799e-05 0.000662191400798927 1.06223203115116 0.654545454545455 4.3 4 3 heart inflammation 0.00443310408138402 0.0350631046182599 1.06109716787001 0.653846153846154 4.3 4 3 decreased circulating glycerol level 0.00443310408138402 0.0350631046182599 1.06109716787001 0.653846153846154 4.3 4 3 abnormal Mullerian duct morphology 0.00443310408138402 0.0350631046182599 1.06109716787001 0.653846153846154 4.3 4 3 pulmonary edema 0.00443310408138402 0.0350631046182599 1.06109716787001 0.653846153846154 4.3 4 3 abnormal nerve conduction 0.00443310408138402 0.0350631046182599 1.06109716787001 0.653846153846154 4.3 4 3 abnormal embryonic tissue morphology 2.18115298675093e-11 1.37357419102353e-09 1.05982334173812 0.653061224489796 4.3 4 3 increased inflammatory response 7.59171284024089e-08 2.50124313776149e-06 1.05912608953961 0.652631578947368 4.3 4 3 decreased rib number 2.13342674845049e-07 6.55172720588963e-06 1.05759056784401 0.651685393258427 4.3 4 3 impaired macrophage phagocytosis 0.000303705640766597 0.00406165473874683 1.05674245993074 0.651162790697674 4.3 4 3 muscular ventricular septal defect 2.22911209060155e-05 0.000428178866824043 1.05485541982372 0.65 4.3 4 3 abnormal pericardium morphology 0.0135390517081335 0.0859306394049962 1.05485541982372 0.65 4.3 4 3 small gonad 0.0135390517081335 0.0859306394049962 1.05485541982372 0.65 4.3 4 3 abnormal circulating enzyme level 0.0135390517081335 0.0859306394049962 1.05485541982372 0.65 4.3 4 3 abnormal physiological neovascularization 0.0135390517081335 0.0859306394049962 1.05485541982372 0.65 4.3 4 3 abnormal optic stalk morphology 0.0135390517081335 0.0859306394049962 1.05485541982372 0.65 4.3 4 3 decreased neutrophil cell number 3.68321990154699e-09 1.62159460267224e-07 1.05416189226302 0.64957264957265 4.3 4 3 decreased brain weight 3.7647315399176e-05 0.000674141614169874 1.05343186325176 0.649122807017544 4.3 4 3 increased macrophage cell number 3.7647315399176e-05 0.000674141614169874 1.05343186325176 0.649122807017544 4.3 4 3 abnormal hepatocyte morphology 1.02893543791704e-08 4.30164185179603e-07 1.05266237321286 0.648648648648649 4.3 4 3 abnormal angiogenesis 2.8447177204759e-06 6.80407243238827e-05 1.05266237321286 0.648648648648649 4.3 4 3 skin inflammation 0.000884482283274305 0.00975676132880193 1.05266237321286 0.648648648648649 4.3 4 3 abnormal blood vessel morphology 6.4775046012225e-11 3.92994943793682e-09 1.05205739483745 0.648275862068965 4.3 4 3 abnormal neural tube morphology 5.17443567986629e-12 3.67754535819069e-10 1.05185013372736 0.648148148148148 4.3 4 3 increased circulating alkaline phosphatase level 5.17443567986629e-12 3.67754535819069e-10 1.05185013372736 0.648148148148148 4.3 4 3 axon degeneration 6.36489614041729e-05 0.00108072895216983 1.05185013372736 0.648148148148148 4.3 4 3 abnormal trophoblast layer morphology 0.000107734438092073 0.00168018441852058 1.05008231837655 0.647058823529412 4.3 4 3 abnormal oocyte morphology 0.00151508484775358 0.0147834596920358 1.05008231837655 0.647058823529412 4.3 4 3 abnormal brown adipose tissue morphology 0.00151508484775358 0.0147834596920358 1.05008231837655 0.647058823529412 4.3 4 3 increased susceptibility to viral infection induced morbidity/mortality 0.00151508484775358 0.0147834596920358 1.05008231837655 0.647058823529412 4.3 4 3 abnormal adipose tissue morphology 0.023953415745123 0.129109689417104 1.05008231837655 0.647058823529412 4.3 4 3 abnormal bone marrow cavity morphology 0.023953415745123 0.129109689417104 1.05008231837655 0.647058823529412 4.3 4 3 hyperlipidemia 0.023953415745123 0.129109689417104 1.05008231837655 0.647058823529412 4.3 4 3 increased regulatory T cell number 0.023953415745123 0.129109689417104 1.05008231837655 0.647058823529412 4.3 4 3 abnormal melanosome morphology 0.023953415745123 0.129109689417104 1.05008231837655 0.647058823529412 4.3 4 3 abnormal circulating chemokine level 0.023953415745123 0.129109689417104 1.05008231837655 0.647058823529412 4.3 4 3 abnormal ductus venosus valve morphology 0.023953415745123 0.129109689417104 1.05008231837655 0.647058823529412 4.3 4 3 overriding aortic valve 0.000182592353071402 0.00267963703991218 1.0480935261069 0.645833333333333 4.3 4 3 abnormal lymph node morphology 0.000182592353071402 0.00267963703991218 1.0480935261069 0.645833333333333 4.3 4 3 abnormal placenta labyrinth morphology 1.73615099837161e-06 4.29718966014865e-05 1.04766555815014 0.645569620253165 4.3 4 3 abnormal visceral yolk sac morphology 1.73615099837161e-06 4.29718966014865e-05 1.04766555815014 0.645569620253165 4.3 4 3 abnormal nervous system morphology 1.73615099837161e-06 4.29718966014865e-05 1.04766555815014 0.645569620253165 4.3 4 3 increased eosinophil cell number 2.28207408724775e-05 0.000433332770383876 1.04700289808806 0.645161290322581 4.3 4 3 abnormal capillary morphology 0.00260327083051725 0.0229985119324336 1.04700289808806 0.645161290322581 4.3 4 3 decreased double-negative T cell number 0.00260327083051725 0.0229985119324336 1.04700289808806 0.645161290322581 4.3 4 3 small superior cervical ganglion 0.0044893708475684 0.0352423484471569 1.04326360202346 0.642857142857143 4.3 4 3 failure of blastocyst to hatch from the zona pellucida 0.0044893708475684 0.0352423484471569 1.04326360202346 0.642857142857143 4.3 4 3 abnormal brainstem morphology 0.0044893708475684 0.0352423484471569 1.04326360202346 0.642857142857143 4.3 4 3 abnormal blood flow velocity 0.0428883043167222 0.199312646076287 1.04326360202346 0.642857142857143 4.3 4 3 abnormal adrenal gland secretion 0.0428883043167222 0.199312646076287 1.04326360202346 0.642857142857143 4.3 4 3 abnormal antigen presentation 0.0428883043167222 0.199312646076287 1.04326360202346 0.642857142857143 4.3 4 3 abnormal sagittal suture morphology 0.0428883043167222 0.199312646076287 1.04326360202346 0.642857142857143 4.3 4 3 abnormal glucose tolerance 0.0428883043167222 0.199312646076287 1.04326360202346 0.642857142857143 4.3 4 3 increased pulmonary respiratory rate 0.0428883043167222 0.199312646076287 1.04326360202346 0.642857142857143 4.3 4 3 decreased compact bone area 0.0428883043167222 0.199312646076287 1.04326360202346 0.642857142857143 4.3 4 3 rib fusion 1.3814929268356e-05 0.00027938728906533 1.04153347996372 0.641791044776119 4.3 4 3 abnormal mesoderm development 0.000109673924297673 0.00170508679181538 1.04107646658945 0.641509433962264 4.3 4 3 abnormal heart looping 0.000897448554573889 0.00976981741576608 1.04029134104903 0.641025641025641 4.3 4 3 decreased placenta weight 0.00777604929468303 0.0551866551227505 1.03862687490336 0.64 4.3 4 3 ventricular septal defect 8.93948504138247e-10 4.53815694702835e-08 1.03814956475864 0.639705882352941 4.3 4 3 decreased spleen weight 1.40206689979589e-05 0.000282400114432573 1.03486373405226 0.63768115942029 4.3 4 3 decreased circulating calcium level 0.000110978440517861 0.00171615085029429 1.0327255858414 0.636363636363636 4.3 4 3 decreased circulating serum albumin level 2.37902016171916e-07 7.12989476177882e-06 1.0327255858414 0.636363636363636 4.3 4 3 increased mean corpuscular hemoglobin 2.37902016171916e-07 7.12989476177882e-06 1.0327255858414 0.636363636363636 4.3 4 3 lethality, incomplete penetrance 0.000532204416699364 0.00636470426220994 1.0327255858414 0.636363636363636 4.3 4 3 abnormal tail movements 0.0135416324208074 0.0859306394049962 1.0327255858414 0.636363636363636 4.3 4 3 intracerebral hemorrhage 0.0135416324208074 0.0859306394049962 1.0327255858414 0.636363636363636 4.3 4 3 increased myocardial infarction size 0.0135416324208074 0.0859306394049962 1.0327255858414 0.636363636363636 4.3 4 3 aphakia 0.0135416324208074 0.0859306394049962 1.0327255858414 0.636363636363636 4.3 4 3 prolonged PR interval 0.0135416324208074 0.0859306394049962 1.0327255858414 0.636363636363636 4.3 4 3 pulmonary vascular congestion 0.0135416324208074 0.0859306394049962 1.0327255858414 0.636363636363636 4.3 4 3 increased bone volume 0.0135416324208074 0.0859306394049962 1.0327255858414 0.636363636363636 4.3 4 3 abnormal large intestine morphology 0.0781067686417797 0.303144373344414 1.0327255858414 0.636363636363636 4.3 4 3 abnormal sebaceous gland morphology 0.0781067686417797 0.303144373344414 1.0327255858414 0.636363636363636 4.3 4 3 abnormal hemoglobin 0.0781067686417797 0.303144373344414 1.0327255858414 0.636363636363636 4.3 4 3 abnormal nerve fiber response 0.0781067686417797 0.303144373344414 1.0327255858414 0.636363636363636 4.3 4 3 pulmonary hypertension 0.0781067686417797 0.303144373344414 1.0327255858414 0.636363636363636 4.3 4 3 pharyngeal arch hypoplasia 0.0781067686417797 0.303144373344414 1.0327255858414 0.636363636363636 4.3 4 3 abnormal spinal cord ventral horn morphology 0.0781067686417797 0.303144373344414 1.0327255858414 0.636363636363636 4.3 4 3 palatal shelf hypoplasia 0.0781067686417797 0.303144373344414 1.0327255858414 0.636363636363636 4.3 4 3 aberrant origin of the right subclavian artery 0.0781067686417797 0.303144373344414 1.0327255858414 0.636363636363636 4.3 4 3 aorta dilation 0.0781067686417797 0.303144373344414 1.0327255858414 0.636363636363636 4.3 4 3 common atrioventricular valve 0.0781067686417797 0.303144373344414 1.0327255858414 0.636363636363636 4.3 4 3 abnormal extraembryonic ectoderm morphology 0.0781067686417797 0.303144373344414 1.0327255858414 0.636363636363636 4.3 4 3 abnormal dendritic cell chemotaxis 0.0781067686417797 0.303144373344414 1.0327255858414 0.636363636363636 4.3 4 3 abnormal pulmonary alveolar sac morphology 0.0781067686417797 0.303144373344414 1.0327255858414 0.636363636363636 4.3 4 3 abnormal ovarian folliculogenesis 0.00262127984205948 0.0229985119324336 1.0327255858414 0.636363636363636 4.3 4 3 abnormal locomotor coordination 0.00262127984205948 0.0229985119324336 1.0327255858414 0.636363636363636 4.3 4 3 abnormal QRS complex 0.00262127984205948 0.0229985119324336 1.0327255858414 0.636363636363636 4.3 4 3 embryonic lethality during organogenesis, incomplete penetrance 5.47281619129443e-15 6.06590375917541e-13 1.03015980798838 0.634782608695652 4.3 4 3 abnormal coat/hair pigmentation 5.26795614396176e-08 1.82000568168123e-06 1.02877382977313 0.633928571428571 4.3 4 3 abnormal pulmonary alveolus morphology 2.40677168052141e-07 7.16987371891856e-06 1.02834344049837 0.633663366336634 4.3 4 3 liver inflammation 1.92410445450439e-08 7.47845286028072e-07 1.02780784495645 0.633333333333333 4.3 4 3 disorganized myocardium 0.00449826960079289 0.0352423484471569 1.02780784495645 0.633333333333333 4.3 4 3 abnormal cellular respiration 0.00449826960079289 0.0352423484471569 1.02780784495645 0.633333333333333 4.3 4 3 decreased circulating creatinine level 0.000316028751896452 0.00414158283875567 1.0267038623088 0.63265306122449 4.3 4 3 lung inflammation 2.57660173513428e-09 1.18643348759769e-07 1.02621681114072 0.632352941176471 4.3 4 3 abnormal compact bone morphology 0.00153637407742514 0.0149578493839336 1.02496073181252 0.631578947368421 4.3 4 3 kyphoscoliosis 0.0237417834701522 0.129109689417104 1.02496073181252 0.631578947368421 4.3 4 3 abnormal stationary movement 0.0237417834701522 0.129109689417104 1.02496073181252 0.631578947368421 4.3 4 3 abnormal digestive system development 0.0237417834701522 0.129109689417104 1.02496073181252 0.631578947368421 4.3 4 3 embryonic lethality between implantation and somite formation, incomplete penetrance 0.0237417834701522 0.129109689417104 1.02496073181252 0.631578947368421 4.3 4 3 decreased hemoglobin content 1.56675041220276e-09 7.71667638075849e-08 1.0243549630585 0.631205673758865 4.3 4 3 astrocytosis 1.42553393525668e-05 0.000285969005157338 1.02262063881752 0.63013698630137 4.3 4 3 decreased tumor growth/size 0.000187916361216623 0.00273357864635292 1.02179727276372 0.62962962962963 4.3 4 3 decreased platelet aggregation 0.000187916361216623 0.00273357864635292 1.02179727276372 0.62962962962963 4.3 4 3 abnormal immune system physiology 1.95533183722112e-08 7.54091154277136e-07 1.02082782563586 0.629032258064516 4.3 4 3 thick pulmonary interalveolar septum 0.00261744329860146 0.0229985119324336 1.02007996642294 0.628571428571429 4.3 4 3 ovary cysts 0.00261744329860146 0.0229985119324336 1.02007996642294 0.628571428571429 4.3 4 3 abnormal left-right axis patterning 0.000903517140524715 0.00979302347300753 1.01900165779036 0.627906976744186 4.3 4 3 abnormal homeostasis 0.000903517140524715 0.00979302347300753 1.01900165779036 0.627906976744186 4.3 4 3 abnormal gastrulation 0.000316342005774302 0.00414158283875567 1.01826164206211 0.627450980392157 4.3 4 3 small lung 0.000316342005774302 0.00414158283875567 1.01826164206211 0.627450980392157 4.3 4 3 decreased body height 0.0133899822510108 0.0859306394049962 1.01428405752281 0.625 4.3 4 3 decreased metastatic potential 0.0133899822510108 0.0859306394049962 1.01428405752281 0.625 4.3 4 3 blindness 0.0133899822510108 0.0859306394049962 1.01428405752281 0.625 4.3 4 3 small lymph nodes 0.0133899822510108 0.0859306394049962 1.01428405752281 0.625 4.3 4 3 abnormal vertebral body morphology 0.00446867859087436 0.0352423484471569 1.01428405752281 0.625 4.3 4 3 abnormal bone marrow cell number 0.041988376890301 0.197284383322086 1.01428405752281 0.625 4.3 4 3 decreased mast cell number 0.041988376890301 0.197284383322086 1.01428405752281 0.625 4.3 4 3 mixed cellular infiltration to dermis 0.041988376890301 0.197284383322086 1.01428405752281 0.625 4.3 4 3 abnormal meiosis 0.041988376890301 0.197284383322086 1.01428405752281 0.625 4.3 4 3 increased cochlear outer hair cell number 0.041988376890301 0.197284383322086 1.01428405752281 0.625 4.3 4 3 sepsis 0.041988376890301 0.197284383322086 1.01428405752281 0.625 4.3 4 3 abnormal Langerhans cell physiology 0.041988376890301 0.197284383322086 1.01428405752281 0.625 4.3 4 3 decreased midbrain size 0.041988376890301 0.197284383322086 1.01428405752281 0.625 4.3 4 3 abnormal ear pigmentation 0.146004889869199 0.445628421533292 1.01428405752281 0.625 4.3 4 3 abnormal bone marrow development 0.146004889869199 0.445628421533292 1.01428405752281 0.625 4.3 4 3 absent pre-B cells 0.146004889869199 0.445628421533292 1.01428405752281 0.625 4.3 4 3 schistocytosis 0.146004889869199 0.445628421533292 1.01428405752281 0.625 4.3 4 3 abnormal cecum morphology 0.146004889869199 0.445628421533292 1.01428405752281 0.625 4.3 4 3 abnormal vagus ganglion morphology 0.146004889869199 0.445628421533292 1.01428405752281 0.625 4.3 4 3 dermal cysts 0.146004889869199 0.445628421533292 1.01428405752281 0.625 4.3 4 3 abnormal erythrocyte cell number 0.146004889869199 0.445628421533292 1.01428405752281 0.625 4.3 4 3 abnormal urination 0.146004889869199 0.445628421533292 1.01428405752281 0.625 4.3 4 3 preneoplasia 0.146004889869199 0.445628421533292 1.01428405752281 0.625 4.3 4 3 abnormal hepatobiliary system morphology 0.146004889869199 0.445628421533292 1.01428405752281 0.625 4.3 4 3 decreased aerobic running capacity 0.146004889869199 0.445628421533292 1.01428405752281 0.625 4.3 4 3 altered response to CNS ischemic injury 0.146004889869199 0.445628421533292 1.01428405752281 0.625 4.3 4 3 abnormal muscle precursor cell migration 0.146004889869199 0.445628421533292 1.01428405752281 0.625 4.3 4 3 abnormal soft palate morphology 0.146004889869199 0.445628421533292 1.01428405752281 0.625 4.3 4 3 abnormal neuron apoptosis 0.146004889869199 0.445628421533292 1.01428405752281 0.625 4.3 4 3 liver cysts 0.146004889869199 0.445628421533292 1.01428405752281 0.625 4.3 4 3 abnormal platelet shape 0.146004889869199 0.445628421533292 1.01428405752281 0.625 4.3 4 3 abnormal eyelid aperture 0.146004889869199 0.445628421533292 1.01428405752281 0.625 4.3 4 3 lymph node inflammation 0.146004889869199 0.445628421533292 1.01428405752281 0.625 4.3 4 3 abnormal vertebral body development 0.146004889869199 0.445628421533292 1.01428405752281 0.625 4.3 4 3 decreased susceptibility to autoimmune disorder 0.146004889869199 0.445628421533292 1.01428405752281 0.625 4.3 4 3 abnormal frontonasal prominence morphology 0.146004889869199 0.445628421533292 1.01428405752281 0.625 4.3 4 3 abnormal olfactory bulb glomerular layer morphology 0.146004889869199 0.445628421533292 1.01428405752281 0.625 4.3 4 3 increased caudal vertebrae number 0.146004889869199 0.445628421533292 1.01428405752281 0.625 4.3 4 3 abnormal circulating serum amyloid protein level 0.146004889869199 0.445628421533292 1.01428405752281 0.625 4.3 4 3 anomalous pulmonary venous connection 0.146004889869199 0.445628421533292 1.01428405752281 0.625 4.3 4 3 delayed suture closure 0.146004889869199 0.445628421533292 1.01428405752281 0.625 4.3 4 3 abnormal bronchiole epithelium morphology 0.146004889869199 0.445628421533292 1.01428405752281 0.625 4.3 4 3 abnormal maxillary prominence morphology 0.146004889869199 0.445628421533292 1.01428405752281 0.625 4.3 4 3 abnormal foramen magnum morphology 0.146004889869199 0.445628421533292 1.01428405752281 0.625 4.3 4 3 absent ureteric bud 0.146004889869199 0.445628421533292 1.01428405752281 0.625 4.3 4 3 abnormal branching involved in ureteric bud morphogenesis 0.146004889869199 0.445628421533292 1.01428405752281 0.625 4.3 4 3 increased aorta wall thickness 0.146004889869199 0.445628421533292 1.01428405752281 0.625 4.3 4 3 impaired neuron differentiation 0.146004889869199 0.445628421533292 1.01428405752281 0.625 4.3 4 3 increased cardiac stroke volume 0.146004889869199 0.445628421533292 1.01428405752281 0.625 4.3 4 3 prolonged PQ interval 0.146004889869199 0.445628421533292 1.01428405752281 0.625 4.3 4 3 increased cornea thickness 0.146004889869199 0.445628421533292 1.01428405752281 0.625 4.3 4 3 increased testis apoptosis 0.146004889869199 0.445628421533292 1.01428405752281 0.625 4.3 4 3 retropleural edema 0.146004889869199 0.445628421533292 1.01428405752281 0.625 4.3 4 3 abnormal umbilical vein topology 0.146004889869199 0.445628421533292 1.01428405752281 0.625 4.3 4 3 premature death 1.16294825379052e-47 1.44641689065196e-44 1.01027875462434 0.62253193960511 4.3 4 3 prenatal lethality, incomplete penetrance 1.46068840027569e-17 2.34416928753921e-15 1.00894572037795 0.621710526315789 4.3 4 3 abnormal branching of the mammary ductal tree 0.0025954773439504 0.0229985119324336 1.00880144099566 0.621621621621622 4.3 4 3 increased circulating phosphate level 0.0025954773439504 0.0229985119324336 1.00880144099566 0.621621621621622 4.3 4 3 increased erythroid progenitor cell number 0.0025954773439504 0.0229985119324336 1.00880144099566 0.621621621621622 4.3 4 3 abnormal calcium ion homeostasis 0.0025954773439504 0.0229985119324336 1.00880144099566 0.621621621621622 4.3 4 3 increased neutrophil cell number 4.35110478548915e-09 1.88232576589639e-07 1.00728899505713 0.620689655172414 4.3 4 3 increased susceptibility to induced arthritis 0.00764772938729728 0.0545092459911232 1.00728899505713 0.620689655172414 4.3 4 3 decreased circulating alkaline phosphatase level 0.000529076690761151 0.00634254587117283 1.00616978506263 0.62 4.3 4 3 small testis 7.93395430831604e-16 1.06679520767222e-13 1.00546419615304 0.619565217391304 4.3 4 3 abnormal heart morphology 1.9361945003553e-13 1.72010136415493e-11 1.00462420935592 0.619047619047619 4.3 4 3 disheveled coat 0.0015154903402891 0.0147834596920358 1.00462420935592 0.619047619047619 4.3 4 3 abnormal pancreas morphology 0.0015154903402891 0.0147834596920358 1.00462420935592 0.619047619047619 4.3 4 3 trunk curl 0.0232605963510079 0.127587063777579 1.00462420935592 0.619047619047619 4.3 4 3 abnormal clavicle morphology 0.0232605963510079 0.127587063777579 1.00462420935592 0.619047619047619 4.3 4 3 abnormal tumor vascularization 0.0232605963510079 0.127587063777579 1.00462420935592 0.619047619047619 4.3 4 3 increased muscle cell glucose uptake 0.0232605963510079 0.127587063777579 1.00462420935592 0.619047619047619 4.3 4 3 abnormal rostral-caudal axis patterning 0.000312482518538429 0.00414158283875567 1.00321914053165 0.618181818181818 4.3 4 3 decreased circulating alanine transaminase level 6.59352727925202e-05 0.00110076504074761 1.00235130390489 0.617647058823529 4.3 4 3 decreased bone trabecula number 0.000888692280545938 0.00976981741576608 1.0013357504055 0.617021276595745 4.3 4 3 increased oxygen consumption 8.44598010447716e-06 0.000184292767630587 1.00013125672016 0.616279069767442 4.3 4 3 impaired macrophage chemotaxis 0.00255865491398713 0.0229985119324336 0.998679687407073 0.615384615384615 4.3 4 3 decreased trabecular bone volume 0.00255865491398713 0.0229985119324336 0.998679687407073 0.615384615384615 4.3 4 3 abnormal leukocyte cell number 0.0131247616359614 0.0854655617001413 0.998679687407073 0.615384615384615 4.3 4 3 short premaxilla 0.0751236000658298 0.299471081993192 0.998679687407073 0.615384615384615 4.3 4 3 absent teeth 0.0751236000658298 0.299471081993192 0.998679687407073 0.615384615384615 4.3 4 3 abnormal mast cell morphology 0.0751236000658298 0.299471081993192 0.998679687407073 0.615384615384615 4.3 4 3 increased pituitary adenoma incidence 0.0751236000658298 0.299471081993192 0.998679687407073 0.615384615384615 4.3 4 3 abnormal bile duct development 0.0751236000658298 0.299471081993192 0.998679687407073 0.615384615384615 4.3 4 3 tracheoesophageal fistula 0.0751236000658298 0.299471081993192 0.998679687407073 0.615384615384615 4.3 4 3 abnormal vertebral arch development 0.0751236000658298 0.299471081993192 0.998679687407073 0.615384615384615 4.3 4 3 absent vitelline blood vessels 0.000308682407592019 0.00410613630419865 0.996489600373285 0.614035087719298 4.3 4 3 decreased susceptibility to induced arthritis 0.000308682407592019 0.00410613630419865 0.996489600373285 0.614035087719298 4.3 4 3 abnormal heart development 2.56545770102759e-09 1.18643348759769e-07 0.99630940333886 0.613924050632911 4.3 4 3 preweaning lethality, incomplete penetrance 1.00857733097805e-21 2.28076010073445e-19 0.995932707826796 0.613691931540342 4.3 4 3 decreased macrophage cell number 0.00149324911365909 0.0147834596920358 0.995842529204212 0.613636363636364 4.3 4 3 decreased blood urea nitrogen level 0.00149324911365909 0.0147834596920358 0.995842529204212 0.613636363636364 4.3 4 3 kyphosis 6.98703182159128e-09 2.94580367054378e-07 0.995350755115716 0.613333333333333 4.3 4 3 preaxial polydactyly 0.00749868432039596 0.0539103388641183 0.994652753183657 0.612903225806452 4.3 4 3 abnormal behavior 5.48674711885213e-15 6.06590375917541e-13 0.992393034698575 0.611510791366906 4.3 4 3 thin ventricular wall 8.2556110094721e-06 0.00018093244393006 0.991744411800079 0.611111111111111 4.3 4 3 increased susceptibility to bacterial infection induced morbidity/mortality 6.43516757016285e-05 0.00108848931308043 0.991744411800079 0.611111111111111 4.3 4 3 abnormal radius morphology 0.0406479257000197 0.196524227752768 0.991744411800079 0.611111111111111 4.3 4 3 increased susceptibility to autoimmune disorder 0.0406479257000197 0.196524227752768 0.991744411800079 0.611111111111111 4.3 4 3 abnormal pregnancy 0.0406479257000197 0.196524227752768 0.991744411800079 0.611111111111111 4.3 4 3 small thoracic cage 0.0406479257000197 0.196524227752768 0.991744411800079 0.611111111111111 4.3 4 3 decreased fluid intake 0.0406479257000197 0.196524227752768 0.991744411800079 0.611111111111111 4.3 4 3 increased adipocyte glucose uptake 0.0406479257000197 0.196524227752768 0.991744411800079 0.611111111111111 4.3 4 3 abnormal small intestine morphology 0.000514949594957382 0.006188102016698 0.991744411800079 0.611111111111111 4.3 4 3 abnormal neuronal precursor proliferation 0.000514949594957382 0.006188102016698 0.991744411800079 0.611111111111111 4.3 4 3 thick ventricular wall 0.00250982573348993 0.022827025638231 0.989545421973471 0.609756097560976 4.3 4 3 abnormal sternum morphology 0.000106581673181962 0.00166897613003181 0.987824473413517 0.608695652173913 4.3 4 3 abnormal postnatal growth 0.0225962674299733 0.125464766142988 0.987824473413517 0.608695652173913 4.3 4 3 pancreas inflammation 0.0225962674299733 0.125464766142988 0.987824473413517 0.608695652173913 4.3 4 3 dilated heart 0.0225962674299733 0.125464766142988 0.987824473413517 0.608695652173913 4.3 4 3 small seminiferous tubules 6.33116805819478e-05 0.00107868359895613 0.986870974887057 0.608108108108108 4.3 4 3 hunched posture 3.76706268822563e-05 0.000674141614169874 0.986038172376603 0.607594936708861 4.3 4 3 abnormal rib morphology 8.29444728201623e-08 2.69705066849874e-06 0.985733839607351 0.607407407407407 4.3 4 3 reddish skin 0.0127773418209097 0.0839726229313417 0.985304513022157 0.607142857142857 4.3 4 3 increased osteoclast cell number 0.000298181077709742 0.00399851984260368 0.984354364022135 0.60655737704918 4.3 4 3 decreased total retina thickness 0.00421943568595582 0.0338030475646219 0.982254034653667 0.605263157894737 4.3 4 3 increased heart weight 8.02017519537436e-08 2.62502444717023e-06 0.98071782252565 0.60431654676259 4.3 4 3 atrioventricular septal defect 0.000839762107493814 0.00934634560353853 0.979836674437128 0.60377358490566 4.3 4 3 gliosis 0.0002917758488252 0.00394452404322111 0.978864614244234 0.603174603174603 4.3 4 3 abnormal seminiferous tubule morphology 4.73285187214997e-08 1.65816465239057e-06 0.978158871912407 0.602739726027397 4.3 4 3 abnormal craniofacial morphology 4.59970460229298e-06 0.000104571960602879 0.97686386899284 0.601941747572815 4.3 4 3 increased sensitivity to xenobiotic induced morbidity/mortality 2.693533266073e-06 6.4859196434859e-05 0.973712695221896 0.6 4.3 4 3 abnormal head morphology 0.000818650209585818 0.00913180446791355 0.973712695221896 0.6 4.3 4 3 decreased birth weight 1.25919237588531e-05 0.000255693145715487 0.973712695221896 0.6 4.3 4 3 absent mesoderm 0.000482154945700451 0.00585053867038961 0.973712695221896 0.6 4.3 4 3 perinatal lethality 0.0041010986230926 0.0331922600061239 0.973712695221896 0.6 4.3 4 3 anencephaly 0.0390458811131804 0.191401578263823 0.973712695221896 0.6 4.3 4 3 abnormal postnatal subventricular zone morphology 0.0390458811131804 0.191401578263823 0.973712695221896 0.6 4.3 4 3 kidney atrophy 0.0390458811131804 0.191401578263823 0.973712695221896 0.6 4.3 4 3 absent incisors 0.0715594340716692 0.294533176847443 0.973712695221896 0.6 4.3 4 3 abnormal prostate gland morphology 0.0715594340716692 0.294533176847443 0.973712695221896 0.6 4.3 4 3 audiogenic seizures 0.0715594340716692 0.294533176847443 0.973712695221896 0.6 4.3 4 3 placental labyrinth hypoplasia 0.0715594340716692 0.294533176847443 0.973712695221896 0.6 4.3 4 3 bicuspid aortic valve 0.0715594340716692 0.294533176847443 0.973712695221896 0.6 4.3 4 3 abnormal coronary vessel morphology 0.0715594340716692 0.294533176847443 0.973712695221896 0.6 4.3 4 3 kidney hemorrhage 0.136598510066174 0.445628421533292 0.973712695221896 0.6 4.3 4 3 abnormal prostate gland epithelium morphology 0.136598510066174 0.445628421533292 0.973712695221896 0.6 4.3 4 3 fused cornea and lens 0.136598510066174 0.445628421533292 0.973712695221896 0.6 4.3 4 3 absent trophoblast giant cells 0.136598510066174 0.445628421533292 0.973712695221896 0.6 4.3 4 3 rhinitis 0.136598510066174 0.445628421533292 0.973712695221896 0.6 4.3 4 3 decreased incidence of induced tumors 0.136598510066174 0.445628421533292 0.973712695221896 0.6 4.3 4 3 abnormal PNS synaptic transmission 0.136598510066174 0.445628421533292 0.973712695221896 0.6 4.3 4 3 acrania 0.136598510066174 0.445628421533292 0.973712695221896 0.6 4.3 4 3 aneurysm 0.136598510066174 0.445628421533292 0.973712695221896 0.6 4.3 4 3 peritoneal inflammation 0.136598510066174 0.445628421533292 0.973712695221896 0.6 4.3 4 3 increased heart rate variability 0.136598510066174 0.445628421533292 0.973712695221896 0.6 4.3 4 3 abnormal reproductive system development 0.136598510066174 0.445628421533292 0.973712695221896 0.6 4.3 4 3 ascites 0.136598510066174 0.445628421533292 0.973712695221896 0.6 4.3 4 3 abnormal hippocampus neuron morphology 0.136598510066174 0.445628421533292 0.973712695221896 0.6 4.3 4 3 abnormal heart and great artery attachment 0.136598510066174 0.445628421533292 0.973712695221896 0.6 4.3 4 3 aorta stenosis 0.136598510066174 0.445628421533292 0.973712695221896 0.6 4.3 4 3 fusion of atlas and odontoid process 0.136598510066174 0.445628421533292 0.973712695221896 0.6 4.3 4 3 abnormal adaptive thermogenesis 0.136598510066174 0.445628421533292 0.973712695221896 0.6 4.3 4 3 increased fatty acid oxidation 0.136598510066174 0.445628421533292 0.973712695221896 0.6 4.3 4 3 abnormal testis morphology 1.61361853947739e-06 4.05442032015154e-05 0.973712695221896 0.6 4.3 4 3 hydroencephaly 1.61361853947739e-06 4.05442032015154e-05 0.973712695221896 0.6 4.3 4 3 short stride length 0.00139466649352223 0.0140454773386095 0.973712695221896 0.6 4.3 4 3 testicular atrophy 0.00139466649352223 0.0140454773386095 0.973712695221896 0.6 4.3 4 3 abnormal dermal layer morphology 0.0070943605957896 0.0514496267697569 0.973712695221896 0.6 4.3 4 3 holoprosencephaly 0.0070943605957896 0.0514496267697569 0.973712695221896 0.6 4.3 4 3 abnormal hippocampus pyramidal cell morphology 0.0070943605957896 0.0514496267697569 0.973712695221896 0.6 4.3 4 3 increased red blood cell distribution width 0.0070943605957896 0.0514496267697569 0.973712695221896 0.6 4.3 4 3 abnormal egg cylinder morphology 0.0218108816855025 0.121920377961096 0.973712695221896 0.6 4.3 4 3 decreased acute inflammation 0.0218108816855025 0.121920377961096 0.973712695221896 0.6 4.3 4 3 double outlet right ventricle 4.395277876353e-06 0.000100767315368001 0.970679322339584 0.598130841121495 4.3 4 3 abnormal locomotor behavior 2.05908636257199e-05 0.000400154478663893 0.97018475067399 0.597826086956522 4.3 4 3 sparse hair 5.79824653439765e-05 0.000994699189952701 0.969754513534002 0.597560975609756 4.3 4 3 decreased white adipose tissue amount 0.000277296678034558 0.00376926495415826 0.968868353454623 0.597014925373134 4.3 4 3 postnatal growth retardation 1.50235171303332e-27 5.33871412310054e-25 0.967878904564248 0.59640522875817 4.3 4 3 abnormal skin condition 0.00135456879657427 0.0138093847601578 0.967470947175602 0.596153846153846 4.3 4 3 decreased hematocrit 1.17156336641816e-07 3.76034048253571e-06 0.967043430186129 0.595890410958904 4.3 4 3 abnormal bone structure 1.18893488863353e-09 5.93267804760362e-08 0.966985837223817 0.595854922279793 4.3 4 3 hepatic necrosis 0.00231417389535731 0.0214395067586641 0.966806931425996 0.595744680851064 4.3 4 3 neuron degeneration 0.00231417389535731 0.0214395067586641 0.966806931425996 0.595744680851064 4.3 4 3 abnormal myocardium layer morphology 9.48774768089096e-05 0.0015226304745946 0.965495710452091 0.594936708860759 4.3 4 3 decreased circulating chloride level 0.00685748759298524 0.0500969174377409 0.964940508778455 0.594594594594595 4.3 4 3 abnormal pancreatic beta cell physiology 0.00685748759298524 0.0500969174377409 0.964940508778455 0.594594594594595 4.3 4 3 increased trabecular bone volume 0.00685748759298524 0.0500969174377409 0.964940508778455 0.594594594594595 4.3 4 3 perimembraneous ventricular septal defect 0.000269440987494565 0.00369014799946477 0.964304843094148 0.594202898550725 4.3 4 3 decreased caudal vertebrae number 0.000455484358922048 0.00559514737194367 0.963569854646668 0.59375 4.3 4 3 increased circulating follicle stimulating hormone level 0.0119271542327737 0.0790830191845579 0.963569854646668 0.59375 4.3 4 3 bradykinesia 0.0119271542327737 0.0790830191845579 0.963569854646668 0.59375 4.3 4 3 pancreatic islet hyperplasia 0.0119271542327737 0.0790830191845579 0.963569854646668 0.59375 4.3 4 3 increased cell proliferation 0.00131221667118317 0.013432670656659 0.96169155083644 0.592592592592593 4.3 4 3 abnormal skin appearance 0.0209493466421043 0.11901752636273 0.96169155083644 0.592592592592593 4.3 4 3 thick interventricular septum 0.0209493466421043 0.11901752636273 0.96169155083644 0.592592592592593 4.3 4 3 polydactyly 1.89650192786434e-05 0.000372928738779647 0.960464903450169 0.591836734693878 4.3 4 3 abnormal ovary morphology 0.000261300570305162 0.00360102586500881 0.959998431908911 0.591549295774648 4.3 4 3 teratozoospermia 5.32366386520939e-05 0.00092605691361597 0.958959472567019 0.590909090909091 4.3 4 3 abnormal germ layer development 0.037299099805742 0.187437395488451 0.958959472567019 0.590909090909091 4.3 4 3 abnormal oogenesis 0.037299099805742 0.187437395488451 0.958959472567019 0.590909090909091 4.3 4 3 testis hypoplasia 0.037299099805742 0.187437395488451 0.958959472567019 0.590909090909091 4.3 4 3 abnormal blood-brain barrier function 0.037299099805742 0.187437395488451 0.958959472567019 0.590909090909091 4.3 4 3 increased rib number 0.000150223078011727 0.00226472670638891 0.957068033765111 0.58974358974359 4.3 4 3 increased urine protein level 0.000150223078011727 0.00226472670638891 0.957068033765111 0.58974358974359 4.3 4 3 decreased regulatory T cell number 0.0114574309330585 0.0763061832556438 0.954620289433231 0.588235294117647 4.3 4 3 increased incidence of corneal inflammation 0.0677526070976981 0.283728299925125 0.954620289433231 0.588235294117647 4.3 4 3 abnormal glutamate-mediated receptor currents 0.0677526070976981 0.283728299925125 0.954620289433231 0.588235294117647 4.3 4 3 coloboma 0.0677526070976981 0.283728299925125 0.954620289433231 0.588235294117647 4.3 4 3 increased circulating magnesium level 0.0677526070976981 0.283728299925125 0.954620289433231 0.588235294117647 4.3 4 3 abnormal survival 0.0677526070976981 0.283728299925125 0.954620289433231 0.588235294117647 4.3 4 3 delayed heart development 0.0677526070976981 0.283728299925125 0.954620289433231 0.588235294117647 4.3 4 3 abnormal cell cytoskeleton morphology 0.0677526070976981 0.283728299925125 0.954620289433231 0.588235294117647 4.3 4 3 cleft palate 1.29777488106194e-06 3.41610054671067e-05 0.953891571655038 0.587786259541985 4.3 4 3 edema 3.38556204983943e-08 1.22051965202545e-06 0.952955254044685 0.587209302325581 4.3 4 3 abnormal myelin sheath morphology 0.00369397225388923 0.0305274285101311 0.952545027934463 0.58695652173913 4.3 4 3 abnormal neurocranium morphology 0.000244480072740903 0.00343584283018642 0.952074635328076 0.586666666666667 4.3 4 3 abnormal retinal pigmentation 8.36628837212429e-05 0.00135137287828956 0.951328495331737 0.586206896551724 4.3 4 3 dermatitis 0.00122325082455403 0.012547779076611 0.951328495331737 0.586206896551724 4.3 4 3 glomerulosclerosis 0.00122325082455403 0.012547779076611 0.951328495331737 0.586206896551724 4.3 4 3 decreased bone strength 0.0200442927685274 0.118432727462498 0.951328495331737 0.586206896551724 4.3 4 3 abnormal neuron morphology 2.88417273547386e-05 0.000531435531814165 0.950763237758753 0.585858585858586 4.3 4 3 liver fibrosis 0.00634760152606107 0.046853586931979 0.949963605094532 0.585365853658537 4.3 4 3 enlarged kidney 0.00207997822209678 0.0194971129404908 0.949216778360968 0.584905660377358 4.3 4 3 decreased grip strength 8.16558881565933e-10 4.23164628728179e-08 0.948517693975667 0.584474885844749 4.3 4 3 increased startle reflex 8.07895374835595e-05 0.00130963566469641 0.948184647032558 0.584269662921348 4.3 4 3 abnormal muscle physiology 8.07895374835595e-05 0.00130963566469641 0.948184647032558 0.584269662921348 4.3 4 3 ataxia 3.82455134394666e-09 1.66904762597672e-07 0.948004109209436 0.584158415841584 4.3 4 3 perinatal lethality, incomplete penetrance 4.77609903558915e-10 2.58272746761478e-08 0.94786191570273 0.584070796460177 4.3 4 3 decreased body length 7.4921794085467e-12 5.1059715832219e-10 0.9476522581235 0.583941605839416 4.3 4 3 abnormal brain morphology 1.44754140156634e-07 4.52925690112738e-06 0.947505107151741 0.583850931677019 4.3 4 3 ocular hypertelorism 0.0354850666805206 0.179774141278605 0.946665120354621 0.583333333333333 4.3 4 3 increased body temperature 0.0354850666805206 0.179774141278605 0.946665120354621 0.583333333333333 4.3 4 3 abnormal lung saccule morphology 0.0354850666805206 0.179774141278605 0.946665120354621 0.583333333333333 4.3 4 3 mesocardia 0.12716166537448 0.445628421533292 0.946665120354621 0.583333333333333 4.3 4 3 abnormal mating frequency 0.12716166537448 0.445628421533292 0.946665120354621 0.583333333333333 4.3 4 3 abnormal pilomotor reflex 0.12716166537448 0.445628421533292 0.946665120354621 0.583333333333333 4.3 4 3 impaired embryo implantation 0.12716166537448 0.445628421533292 0.946665120354621 0.583333333333333 4.3 4 3 small thyroid gland 0.12716166537448 0.445628421533292 0.946665120354621 0.583333333333333 4.3 4 3 loss of dopaminergic neurons 0.12716166537448 0.445628421533292 0.946665120354621 0.583333333333333 4.3 4 3 decreased left ventricle systolic pressure 0.12716166537448 0.445628421533292 0.946665120354621 0.583333333333333 4.3 4 3 increased hepatocyte proliferation 0.12716166537448 0.445628421533292 0.946665120354621 0.583333333333333 4.3 4 3 abnormal cochlear outer hair cell physiology 0.12716166537448 0.445628421533292 0.946665120354621 0.583333333333333 4.3 4 3 increased skeletal muscle glycogen level 0.12716166537448 0.445628421533292 0.946665120354621 0.583333333333333 4.3 4 3 abnormal eye morphology 1.13633429005163e-06 3.00705483670578e-05 0.945692186006877 0.58273381294964 4.3 4 3 perinatal lethality, complete penetrance 2.0889972082696e-09 9.89786772489642e-08 0.944760361561151 0.582159624413146 4.3 4 3 abnormal liver morphology 4.59182880580799e-08 1.62016654673012e-06 0.942887526099415 0.581005586592179 4.3 4 3 hypoglycemia 7.50683465227226e-05 0.00123663915215412 0.942302608279254 0.580645161290323 4.3 4 3 abnormal retinal photoreceptor layer morphology 0.0191194748701186 0.113237366046238 0.942302608279254 0.580645161290323 4.3 4 3 persistence of hyaloid vascular system 0.0104848089651507 0.0705844717207368 0.939547337494812 0.578947368421053 4.3 4 3 abnormal triglyceride level 0.0638938712660874 0.270069676761924 0.939547337494812 0.578947368421053 4.3 4 3 abnormal long term depression 0.0638938712660874 0.270069676761924 0.939547337494812 0.578947368421053 4.3 4 3 increased susceptibility to ischemic brain injury 0.0638938712660874 0.270069676761924 0.939547337494812 0.578947368421053 4.3 4 3 Leydig cell hypoplasia 0.0638938712660874 0.270069676761924 0.939547337494812 0.578947368421053 4.3 4 3 decreased susceptibility to weight gain 0.0638938712660874 0.270069676761924 0.939547337494812 0.578947368421053 4.3 4 3 shortened RR interval 0.0638938712660874 0.270069676761924 0.939547337494812 0.578947368421053 4.3 4 3 decreased total body fat amount 2.18220084710237e-13 1.9046402130411e-11 0.937757236416297 0.577844311377245 4.3 4 3 albuminuria 0.00581956648823547 0.0443374322802013 0.937649262065529 0.577777777777778 4.3 4 3 abnormal skeletal muscle fiber morphology 0.000617966515678022 0.00719996116041724 0.937141326387271 0.577464788732394 4.3 4 3 cachexia 4.00263740220665e-05 0.000706660170148553 0.936262206944131 0.576923076923077 4.3 4 3 abnormal snout morphology 0.00325871232271328 0.0273852935903692 0.936262206944131 0.576923076923077 4.3 4 3 increased susceptibility to otitis media 0.0336555908439675 0.171203031133679 0.936262206944131 0.576923076923077 4.3 4 3 abnormal erythrocyte osmotic lysis 0.0336555908439675 0.171203031133679 0.936262206944131 0.576923076923077 4.3 4 3 abnormal aorta morphology 0.0181921649965071 0.109837403953426 0.934370768142223 0.575757575757576 4.3 4 3 increased osteoblast cell number 0.0181921649965071 0.109837403953426 0.934370768142223 0.575757575757576 4.3 4 3 decreased percent body fat/body weight 0.000592479953701509 0.00695185794732313 0.933697105007297 0.575342465753425 4.3 4 3 increased bone mineral density 2.21951971857147e-05 0.000427988782941592 0.933500371525416 0.575221238938053 4.3 4 3 decreased body size 2.76321696269444e-29 1.24972767176408e-26 0.933446380757832 0.575187969924812 4.3 4 3 decreased circulating phosphate level 0.0099968854997237 0.067665993688606 0.933141332920984 0.575 4.3 4 3 abnormal pancreatic beta cell morphology 0.0099968854997237 0.067665993688606 0.933141332920984 0.575 4.3 4 3 diluted coat color 0.00311478726898034 0.0262645197680969 0.931638689872802 0.574074074074074 4.3 4 3 abnormal cell adhesion 0.00311478726898034 0.0262645197680969 0.931638689872802 0.574074074074074 4.3 4 3 delayed bone ossification 0.000567407559372534 0.00668922418928521 0.930436575434256 0.573333333333333 4.3 4 3 retinal degeneration 0.000106680283286455 0.00166897613003181 0.929760386062574 0.572916666666667 4.3 4 3 azoospermia 7.75325527059684e-07 2.1077838782087e-05 0.928803514310194 0.572327044025157 4.3 4 3 rib bifurcation 0.0318453530703637 0.167829058818919 0.927345424020853 0.571428571428571 4.3 4 3 abnormal circulating cholesterol level 0.0318453530703637 0.167829058818919 0.927345424020853 0.571428571428571 4.3 4 3 straub tail 0.0318453530703637 0.167829058818919 0.927345424020853 0.571428571428571 4.3 4 3 abnormal retinal inner nuclear layer morphology 0.0318453530703637 0.167829058818919 0.927345424020853 0.571428571428571 4.3 4 3 corneal vascularization 0.0318453530703637 0.167829058818919 0.927345424020853 0.571428571428571 4.3 4 3 midline facial cleft 0.118103994397974 0.422102997219769 0.927345424020853 0.571428571428571 4.3 4 3 absent visceral yolk sac blood islands 0.118103994397974 0.422102997219769 0.927345424020853 0.571428571428571 4.3 4 3 increased lactate dehydrogenase level 0.118103994397974 0.422102997219769 0.927345424020853 0.571428571428571 4.3 4 3 amyloid beta deposits 0.118103994397974 0.422102997219769 0.927345424020853 0.571428571428571 4.3 4 3 abnormal pancreas development 0.118103994397974 0.422102997219769 0.927345424020853 0.571428571428571 4.3 4 3 decreased CNS synapse formation 0.118103994397974 0.422102997219769 0.927345424020853 0.571428571428571 4.3 4 3 abnormal viscerocranium morphology 0.118103994397974 0.422102997219769 0.927345424020853 0.571428571428571 4.3 4 3 abnormal renal tubule epithelial cell primary cilium morphology 0.118103994397974 0.422102997219769 0.927345424020853 0.571428571428571 4.3 4 3 abnormal respiratory system physiology 0.00529752570180982 0.0406715900717652 0.927345424020853 0.571428571428571 4.3 4 3 abnormal craniofacial development 0.00529752570180982 0.0406715900717652 0.927345424020853 0.571428571428571 4.3 4 3 domed cranium 0.000952770613681484 0.0103044213110117 0.927345424020853 0.571428571428571 4.3 4 3 decreased triglyceride level 0.0172748580494171 0.104862594966221 0.927345424020853 0.571428571428571 4.3 4 3 decreased glycogen level 0.0172748580494171 0.104862594966221 0.927345424020853 0.571428571428571 4.3 4 3 skin edema 0.00951495867458572 0.0646679226858797 0.927345424020853 0.571428571428571 4.3 4 3 abnormal reproductive system morphology 0.00951495867458572 0.0646679226858797 0.927345424020853 0.571428571428571 4.3 4 3 abnormal scapula morphology 0.0600929274627436 0.255960885382833 0.927345424020853 0.571428571428571 4.3 4 3 abnormal embryonic/fetal subventricular zone morphology 0.0600929274627436 0.255960885382833 0.927345424020853 0.571428571428571 4.3 4 3 vascular ring 0.0600929274627436 0.255960885382833 0.927345424020853 0.571428571428571 4.3 4 3 decreased body weight 3.21603205703563e-43 2.66662658062538e-40 0.926783623481261 0.57108239095315 4.3 4 3 abnormal bone mineralization 1.87703396397899e-05 0.000370565236936328 0.925429421078661 0.570247933884298 4.3 4 3 decreased circulating glucose level 1.16712174457291e-10 6.67405825201177e-09 0.924852559977786 0.56989247311828 4.3 4 3 abnormal lipid homeostasis 1.03975166170417e-05 0.00022011763902035 0.923778710851542 0.569230769230769 4.3 4 3 abnormal renal glomerulus morphology 5.38940210231923e-05 0.000934225625750458 0.923091545929014 0.568807339449541 4.3 4 3 abnormal cervical vertebrae morphology 0.00504362342407903 0.0392062914606143 0.92279961311879 0.568627450980392 4.3 4 3 impaired glucose tolerance 1.58211254439671e-09 7.71667638075849e-08 0.922671303940103 0.568548387096774 4.3 4 3 abnormal long bone metaphysis morphology 0.0163765024879414 0.0999669937147343 0.921079576561253 0.567567567567568 4.3 4 3 abnormal vocalization 0.0163765024879414 0.0999669937147343 0.921079576561253 0.567567567567568 4.3 4 3 abnormal myocardial fiber morphology 0.000155424472896013 0.00233606269685095 0.920175227443372 0.56701030927835 4.3 4 3 abnormal enzyme/coenzyme activity 1.77739266978338e-06 4.37748937236254e-05 0.919962100581197 0.56687898089172 4.3 4 3 increased susceptibility to parasitic infection 0.000270734476342642 0.00369014799946477 0.919617545487346 0.566666666666667 4.3 4 3 abnormal eating behavior 0.00269926157837156 0.023354480612867 0.919617545487346 0.566666666666667 4.3 4 3 abnormal heart tube morphology 0.030077396839685 0.159695890370793 0.919617545487346 0.566666666666667 4.3 4 3 abnormal response to new environment 0.030077396839685 0.159695890370793 0.919617545487346 0.566666666666667 4.3 4 3 abnormal fat pad morphology 0.030077396839685 0.159695890370793 0.919617545487346 0.566666666666667 4.3 4 3 male infertility 1.81713352509448e-17 2.73946645071062e-15 0.919510000458053 0.566600397614314 4.3 4 3 increased circulating bilirubin level 0.00479619158438704 0.0373997697998832 0.918596882284807 0.566037735849057 4.3 4 3 weight loss 5.49502535641939e-07 1.53582871619025e-05 0.918071969780645 0.565714285714286 4.3 4 3 atrial septal defect 0.00858283899288559 0.0591407534482075 0.917265582455409 0.565217391304348 4.3 4 3 abnormal pulmonary artery morphology 0.0564127818942414 0.241318649977516 0.917265582455409 0.565217391304348 4.3 4 3 conjunctivitis 0.0564127818942414 0.241318649977516 0.917265582455409 0.565217391304348 4.3 4 3 abnormal nasal cavity morphology 0.0564127818942414 0.241318649977516 0.917265582455409 0.565217391304348 4.3 4 3 abnormal lung development 0.000450754948098838 0.0055507570960191 0.916435477855902 0.564705882352941 4.3 4 3 enlarged heart 1.04919545578221e-08 4.34978949376374e-07 0.916353183003365 0.564655172413793 4.3 4 3 prenatal lethality 0.00256800525511562 0.0229985119324336 0.916127535827052 0.564516129032258 4.3 4 3 reduced male fertility 1.71872111139932e-08 6.73278545607212e-07 0.915089757624102 0.563876651982379 4.3 4 3 increased circulating calcium level 0.00455611862101806 0.0356394499049762 0.914699804602387 0.563636363636364 4.3 4 3 abnormal posture 0.000750865196512358 0.00848989625602042 0.912855651770527 0.5625 4.3 4 3 abnormal osteoclast morphology 0.00813730448881364 0.0563047146479108 0.912855651770527 0.5625 4.3 4 3 decreased circulating LDL cholesterol level 0.00244097126403809 0.0224470093134741 0.912855651770527 0.5625 4.3 4 3 failure of primitive streak formation 0.0283667442609906 0.151583837484885 0.912855651770527 0.5625 4.3 4 3 neonatal lethality 0.0283667442609906 0.151583837484885 0.912855651770527 0.5625 4.3 4 3 decreased susceptibility to parasitic infection 0.0283667442609906 0.151583837484885 0.912855651770527 0.5625 4.3 4 3 vasculature congestion 0.109579364733428 0.396478065126404 0.912855651770527 0.5625 4.3 4 3 white spotting 0.109579364733428 0.396478065126404 0.912855651770527 0.5625 4.3 4 3 paternal imprinting 0.109579364733428 0.396478065126404 0.912855651770527 0.5625 4.3 4 3 increased pancreatic beta cell number 0.109579364733428 0.396478065126404 0.912855651770527 0.5625 4.3 4 3 increased thymus weight 0.109579364733428 0.396478065126404 0.912855651770527 0.5625 4.3 4 3 abnormal amnion morphology 0.109579364733428 0.396478065126404 0.912855651770527 0.5625 4.3 4 3 decreased creatinine clearance 0.109579364733428 0.396478065126404 0.912855651770527 0.5625 4.3 4 3 kidney degeneration 0.109579364733428 0.396478065126404 0.912855651770527 0.5625 4.3 4 3 abnormal pulmonary alveolus wall morphology 0.109579364733428 0.396478065126404 0.912855651770527 0.5625 4.3 4 3 increased circulating HDL cholesterol level 0.000128645614568821 0.00196322678674811 0.911889666953839 0.561904761904762 4.3 4 3 neonatal lethality, incomplete penetrance 2.59942211353061e-09 1.18643348759769e-07 0.911295214758954 0.561538461538462 4.3 4 3 abnormal craniofacial bone morphology 0.00432404155273219 0.0344745300077606 0.911076206055575 0.56140350877193 4.3 4 3 abnormal mammary gland development 0.0146598594660704 0.0905997526008697 0.910381788215594 0.560975609756098 4.3 4 3 hemopericardium 0.0146598594660704 0.0905997526008697 0.910381788215594 0.560975609756098 4.3 4 3 insulin resistance 2.14746247402648e-05 0.00041570528436894 0.909782063717428 0.560606060606061 4.3 4 3 small ovary 0.00038914811254127 0.00494916623845346 0.909511858174298 0.56043956043956 4.3 4 3 enlarged liver 0.000212750836821245 0.00303276622689311 0.908798515540436 0.56 4.3 4 3 abnormal liver physiology 0.000212750836821245 0.00303276622689311 0.908798515540436 0.56 4.3 4 3 abnormal interventricular septum morphology 0.00770745286100341 0.0547779685478456 0.908798515540436 0.56 4.3 4 3 abnormal circulating protein level 0.00770745286100341 0.0547779685478456 0.908798515540436 0.56 4.3 4 3 abnormal thyroid gland morphology 0.0528885748559983 0.238892408867074 0.908798515540436 0.56 4.3 4 3 increased insulin sensitivity 1.13055368786255e-05 0.000235334920381429 0.907890624915521 0.559440559440559 4.3 4 3 lung hemorrhage 0.0267228281435418 0.14341539375849 0.90688927496157 0.558823529411765 4.3 4 3 delayed endochondral bone ossification 0.0138487055064574 0.0877672737511152 0.905779251369205 0.558139534883721 4.3 4 3 impaired coordination 1.75314570941376e-11 1.13271427329006e-09 0.905233864055038 0.557803468208092 4.3 4 3 abnormal brain wave pattern 0.0072941635084097 0.0525158660699541 0.90505346671266 0.557692307692308 4.3 4 3 decreased heart weight 0.001070119581433 0.0114245599090755 0.901585828909163 0.555555555555556 4.3 4 3 renal hypoplasia 0.0251511576632237 0.135418841314435 0.901585828909163 0.555555555555556 4.3 4 3 abnormal mitral valve morphology 0.101633458844796 0.371510990266613 0.901585828909163 0.555555555555556 4.3 4 3 cortical renal glomerulopathies 0.101633458844796 0.371510990266613 0.901585828909163 0.555555555555556 4.3 4 3 right pulmonary isomerism 0.101633458844796 0.371510990266613 0.901585828909163 0.555555555555556 4.3 4 3 abnormal mammary gland morphology 0.101633458844796 0.371510990266613 0.901585828909163 0.555555555555556 4.3 4 3 absent spleen 0.101633458844796 0.371510990266613 0.901585828909163 0.555555555555556 4.3 4 3 abnormal metacarpal bone morphology 0.101633458844796 0.371510990266613 0.901585828909163 0.555555555555556 4.3 4 3 abnormal eye anterior chamber morphology 0.101633458844796 0.371510990266613 0.901585828909163 0.555555555555556 4.3 4 3 darkened coat color 0.101633458844796 0.371510990266613 0.901585828909163 0.555555555555556 4.3 4 3 abnormal glycogen homeostasis 0.101633458844796 0.371510990266613 0.901585828909163 0.555555555555556 4.3 4 3 abnormal head movements 0.228656159629184 0.602842816192469 0.901585828909163 0.555555555555556 4.3 4 3 abnormal sympathetic neuron morphology 0.228656159629184 0.602842816192469 0.901585828909163 0.555555555555556 4.3 4 3 abnormal cholinergic neuron morphology 0.228656159629184 0.602842816192469 0.901585828909163 0.555555555555556 4.3 4 3 abnormal vomeronasal organ morphology 0.228656159629184 0.602842816192469 0.901585828909163 0.555555555555556 4.3 4 3 abnormal NMDA-mediated synaptic currents 0.228656159629184 0.602842816192469 0.901585828909163 0.555555555555556 4.3 4 3 genetic imprinting 0.228656159629184 0.602842816192469 0.901585828909163 0.555555555555556 4.3 4 3 priapism 0.228656159629184 0.602842816192469 0.901585828909163 0.555555555555556 4.3 4 3 decreased muscle weight 0.228656159629184 0.602842816192469 0.901585828909163 0.555555555555556 4.3 4 3 decreased cochlear hair cell number 0.228656159629184 0.602842816192469 0.901585828909163 0.555555555555556 4.3 4 3 abnormal inguinal fat pad morphology 0.228656159629184 0.602842816192469 0.901585828909163 0.555555555555556 4.3 4 3 abnormal optic chiasm morphology 0.228656159629184 0.602842816192469 0.901585828909163 0.555555555555556 4.3 4 3 multiflagellated sperm 0.228656159629184 0.602842816192469 0.901585828909163 0.555555555555556 4.3 4 3 abnormal hippocampus granule cell morphology 0.228656159629184 0.602842816192469 0.901585828909163 0.555555555555556 4.3 4 3 axonal spheroids 0.228656159629184 0.602842816192469 0.901585828909163 0.555555555555556 4.3 4 3 prolonged RR interval 0.228656159629184 0.602842816192469 0.901585828909163 0.555555555555556 4.3 4 3 fusion of atlas and occipital bones 0.228656159629184 0.602842816192469 0.901585828909163 0.555555555555556 4.3 4 3 decreased susceptibility to parasitic infection induced morbidity/mortality 0.228656159629184 0.602842816192469 0.901585828909163 0.555555555555556 4.3 4 3 reduced AMPA-mediated synaptic currents 0.228656159629184 0.602842816192469 0.901585828909163 0.555555555555556 4.3 4 3 decreased pancreatic beta cell proliferation 0.228656159629184 0.602842816192469 0.901585828909163 0.555555555555556 4.3 4 3 increased bone mineralization 0.228656159629184 0.602842816192469 0.901585828909163 0.555555555555556 4.3 4 3 decreased insulin secretion 0.000581694346502877 0.00684144060012249 0.901585828909163 0.555555555555556 4.3 4 3 decreased susceptibility to hepatic steatosis 0.00367933114047614 0.0304570256636752 0.901585828909163 0.555555555555556 4.3 4 3 increased circulating aspartate transaminase level 0.00367933114047614 0.0304570256636752 0.901585828909163 0.555555555555556 4.3 4 3 abnormal osteoblast physiology 0.00689794697864531 0.0503186014937836 0.901585828909163 0.555555555555556 4.3 4 3 abnormal ectoderm development 0.0130716316509159 0.0852311500174399 0.901585828909163 0.555555555555556 4.3 4 3 abnormal metabolism 0.0130716316509159 0.0852311500174399 0.901585828909163 0.555555555555556 4.3 4 3 cardiomyopathy 0.0130716316509159 0.0852311500174399 0.901585828909163 0.555555555555556 4.3 4 3 abnormal brain commissure morphology 0.0495383960962964 0.227565577635341 0.901585828909163 0.555555555555556 4.3 4 3 limb grasping 1.43011223094138e-06 3.67160529924072e-05 0.900595075251021 0.554945054945055 4.3 4 3 reduced fertility 2.61323944395161e-05 0.000490598725798463 0.89899133731518 0.553956834532374 4.3 4 3 cataract 8.60672452207623e-05 0.00138571050153169 0.898605379887975 0.553719008264463 4.3 4 3 reduced female fertility 9.59068906603849e-08 3.09829078594425e-06 0.895367995606341 0.551724137931034 4.3 4 3 abnormal microglial cell morphology 0.0463697349803162 0.213601325488031 0.895367995606341 0.551724137931034 4.3 4 3 abnormal outer ear morphology 0.0463697349803162 0.213601325488031 0.895367995606341 0.551724137931034 4.3 4 3 infertility 0.000257151577634759 0.00355369194092479 0.894845000281804 0.551401869158878 4.3 4 3 abnormal cornea morphology 0.00167965480178807 0.0163208645290931 0.894650553302169 0.551282051282051 4.3 4 3 abnormal cell proliferation 0.0942636370085294 0.348929757527852 0.892569970620071 0.55 4.3 4 3 dilated vasculature 0.0942636370085294 0.348929757527852 0.892569970620071 0.55 4.3 4 3 abnormal induced retinal neovascularization 0.0942636370085294 0.348929757527852 0.892569970620071 0.55 4.3 4 3 abnormal glucose homeostasis 2.92811045404701e-06 6.97002368846119e-05 0.891678292327743 0.549450549450549 4.3 4 3 increased circulating free fatty acid level 0.00294270125194469 0.0253725107944971 0.891427115343989 0.549295774647887 4.3 4 3 decreased bone mineral density 1.97110608843813e-08 7.54327137690746e-07 0.890739683598977 0.548872180451128 4.3 4 3 lethargy 0.000772629196249125 0.00871616837038412 0.889952463374851 0.548387096774194 4.3 4 3 small cranium 0.0433834449455871 0.200494230266084 0.889952463374851 0.548387096774194 4.3 4 3 decreased bone mineral content 7.32659085828247e-07 2.01380052596438e-05 0.889449096596924 0.548076923076923 4.3 4 3 abnormal fertility/fecundity 0.00277980251859394 0.0240095790451473 0.889235338102188 0.547945205479452 4.3 4 3 arrest of spermatogenesis 0.00142078158038368 0.0142795724493107 0.888706031353317 0.547619047619048 4.3 4 3 spina bifida 0.0208878972662887 0.11901752636273 0.888706031353317 0.547619047619048 4.3 4 3 abnormal coat/ hair morphology 0.0103125462499371 0.0695188585276926 0.887976986208647 0.547169811320755 4.3 4 3 abnormal placenta development 0.0103125462499371 0.0695188585276926 0.887976986208647 0.547169811320755 4.3 4 3 abnormal pancreatic islet morphology 0.0103125462499371 0.0695188585276926 0.887976986208647 0.547169811320755 4.3 4 3 abnormal tooth morphology 0.00517390340514279 0.0400937218700707 0.887498550332457 0.546875 4.3 4 3 decreased eosinophil cell number 0.00517390340514279 0.0400937218700707 0.887498550332457 0.546875 4.3 4 3 decreased circulating cholesterol level 4.04645307408055e-06 9.36330420630267e-05 0.886805733353275 0.546448087431694 4.3 4 3 cochlear hair cell degeneration 0.0196159042415609 0.116039385971184 0.885193359292633 0.545454545454545 4.3 4 3 abnormal long bone epiphysis morphology 0.0874455206511457 0.326118039909633 0.885193359292633 0.545454545454545 4.3 4 3 abnormal enterocyte morphology 0.0874455206511457 0.326118039909633 0.885193359292633 0.545454545454545 4.3 4 3 abnormal facial nerve morphology 0.0874455206511457 0.326118039909633 0.885193359292633 0.545454545454545 4.3 4 3 abnormal chorion morphology 0.0874455206511457 0.326118039909633 0.885193359292633 0.545454545454545 4.3 4 3 abnormal female reproductive system physiology 0.0874455206511457 0.326118039909633 0.885193359292633 0.545454545454545 4.3 4 3 abnormal retinal outer plexiform layer morphology 0.0874455206511457 0.326118039909633 0.885193359292633 0.545454545454545 4.3 4 3 cleft upper lip 0.0874455206511457 0.326118039909633 0.885193359292633 0.545454545454545 4.3 4 3 abnormal cerebral cortex pyramidal cell morphology 0.0874455206511457 0.326118039909633 0.885193359292633 0.545454545454545 4.3 4 3 rough coat 0.0874455206511457 0.326118039909633 0.885193359292633 0.545454545454545 4.3 4 3 absent semicircular canals 0.206788599775448 0.559419947734015 0.885193359292633 0.545454545454545 4.3 4 3 social withdrawal 0.206788599775448 0.559419947734015 0.885193359292633 0.545454545454545 4.3 4 3 failure of somite differentiation 0.206788599775448 0.559419947734015 0.885193359292633 0.545454545454545 4.3 4 3 abnormal larynx morphology 0.206788599775448 0.559419947734015 0.885193359292633 0.545454545454545 4.3 4 3 abnormal bronchiole morphology 0.206788599775448 0.559419947734015 0.885193359292633 0.545454545454545 4.3 4 3 fatigue 0.206788599775448 0.559419947734015 0.885193359292633 0.545454545454545 4.3 4 3 decreased post-tetanic potentiation 0.206788599775448 0.559419947734015 0.885193359292633 0.545454545454545 4.3 4 3 rectal hemorrhage 0.206788599775448 0.559419947734015 0.885193359292633 0.545454545454545 4.3 4 3 pathological neovascularization 0.206788599775448 0.559419947734015 0.885193359292633 0.545454545454545 4.3 4 3 abnormal coronal suture morphology 0.206788599775448 0.559419947734015 0.885193359292633 0.545454545454545 4.3 4 3 abnormal palate development 0.206788599775448 0.559419947734015 0.885193359292633 0.545454545454545 4.3 4 3 decreased palatine bone horizontal plate size 0.206788599775448 0.559419947734015 0.885193359292633 0.545454545454545 4.3 4 3 abnormal brain ependyma motile cilium morphology 0.206788599775448 0.559419947734015 0.885193359292633 0.545454545454545 4.3 4 3 increased pancreatic beta cell proliferation 0.206788599775448 0.559419947734015 0.885193359292633 0.545454545454545 4.3 4 3 chylous ascites 0.206788599775448 0.559419947734015 0.885193359292633 0.545454545454545 4.3 4 3 abnormal tooth development 0.0405762393783711 0.196524227752768 0.885193359292632 0.545454545454545 4.3 4 3 enlarged pericardium 0.0405762393783711 0.196524227752768 0.885193359292632 0.545454545454545 4.3 4 3 decreased systemic arterial blood pressure 0.0405762393783711 0.196524227752768 0.885193359292632 0.545454545454545 4.3 4 3 no abnormal phenotype detected 1.29397175863884e-45 1.28750189984564e-42 0.883917864538608 0.544668587896254 4.3 4 3 decreased bone volume 0.0379422926303148 0.190477200641591 0.88097815281981 0.542857142857143 4.3 4 3 abnormal lipid level 0.00208099838621118 0.0194971129404908 0.879860869176412 0.542168674698795 4.3 4 3 abnormal neuromuscular synapse morphology 0.00408255724281891 0.0331333153067277 0.879046183186434 0.541666666666667 4.3 4 3 abnormal intestinal epithelium morphology 0.0172838849994575 0.104862594966221 0.879046183186434 0.541666666666667 4.3 4 3 abnormal kidney physiology 0.0172838849994575 0.104862594966221 0.879046183186434 0.541666666666667 4.3 4 3 abnormal impulse conducting system conduction 0.0811455362377295 0.306762190564365 0.879046183186434 0.541666666666667 4.3 4 3 prolonged QT interval 0.0811455362377295 0.306762190564365 0.879046183186434 0.541666666666667 4.3 4 3 hypopigmentation 0.0811455362377295 0.306762190564365 0.879046183186434 0.541666666666667 4.3 4 3 increased circulating total protein level 0.0811455362377295 0.306762190564365 0.879046183186434 0.541666666666667 4.3 4 3 abnormal truncus arteriosus septation 0.0811455362377295 0.306762190564365 0.879046183186434 0.541666666666667 4.3 4 3 malocclusion 0.0354742813988499 0.179774141278605 0.87721864434405 0.540540540540541 4.3 4 3 kidney inflammation 0.0162183978274981 0.0992454233601512 0.876341425699706 0.54 4.3 4 3 abnormal axial skeleton morphology 0.00362110107960004 0.0300750882654594 0.875487291756529 0.539473684210526 4.3 4 3 kinked tail 0.000846819107260144 0.00940385057727503 0.875068598647128 0.53921568627451 4.3 4 3 abnormal skeleton morphology 0.000413724452896344 0.00519767462919018 0.874930247880544 0.539130434782609 4.3 4 3 abnormal female meiosis 0.0152159564900474 0.0938034492416181 0.873844726481189 0.538461538461538 4.3 4 3 abnormal nasal bone morphology 0.0753270562033677 0.299801683689404 0.873844726481189 0.538461538461538 4.3 4 3 ventricular hypoplasia 0.0753270562033677 0.299801683689404 0.873844726481189 0.538461538461538 4.3 4 3 absent myocardial trabeculae 0.187872741567905 0.517534268715574 0.873844726481189 0.538461538461538 4.3 4 3 axonal dystrophy 0.187872741567905 0.517534268715574 0.873844726481189 0.538461538461538 4.3 4 3 small otic vesicle 0.187872741567905 0.517534268715574 0.873844726481189 0.538461538461538 4.3 4 3 increased cochlear inner hair cell number 0.187872741567905 0.517534268715574 0.873844726481189 0.538461538461538 4.3 4 3 increased circulating ammonia level 0.187872741567905 0.517534268715574 0.873844726481189 0.538461538461538 4.3 4 3 increased circulating thyroxine level 0.187872741567905 0.517534268715574 0.873844726481189 0.538461538461538 4.3 4 3 increased prostaglandin level 0.187872741567905 0.517534268715574 0.873844726481189 0.538461538461538 4.3 4 3 abnormal aorta tunica media morphology 0.187872741567905 0.517534268715574 0.873844726481189 0.538461538461538 4.3 4 3 abnormal hair follicle inner root sheath morphology 0.187872741567905 0.517534268715574 0.873844726481189 0.538461538461538 4.3 4 3 decreased startle reflex 0.000390431826364771 0.00494916623845346 0.873844726481188 0.538461538461538 4.3 4 3 absent gastric milk in neonates 0.0034093303940795 0.0286027296973786 0.873844726481188 0.538461538461538 4.3 4 3 acanthosis 0.0331640683637508 0.169048401751701 0.873844726481188 0.538461538461538 4.3 4 3 decreased monocyte cell number 0.00714769221331306 0.0517609443394941 0.873844726481188 0.538461538461538 4.3 4 3 abnormal retina morphology 2.6986640526665e-06 6.4859196434859e-05 0.873250274286303 0.538095238095238 4.3 4 3 abnormal axon morphology 0.000710156047772306 0.00817830170756302 0.871532967945524 0.537037037037037 4.3 4 3 impaired limb coordination 0.0142734814046356 0.089624097246883 0.871532967945524 0.537037037037037 4.3 4 3 scaly skin 0.0310031528973587 0.164435699002516 0.870799971336655 0.536585365853659 4.3 4 3 abnormal renal tubule epithelium morphology 0.0699534457416039 0.292206878727523 0.86938633501955 0.535714285714286 4.3 4 3 prolonged QRS complex duration 0.0699534457416039 0.292206878727523 0.86938633501955 0.535714285714286 4.3 4 3 atelectasis 0.00593491161632618 0.045082729787687 0.868570009822348 0.535211267605634 4.3 4 3 decreased oxygen consumption 0.0289829677900945 0.154710584501846 0.868038449228822 0.534883720930233 4.3 4 3 increased circulating cholesterol level 2.63152073384006e-05 0.000492173520708809 0.866751830974036 0.534090909090909 4.3 4 3 female infertility 2.87505072766942e-07 8.31591707567173e-06 0.86633585665106 0.533834586466165 4.3 4 3 abnormal fontanelle morphology 0.171297777628035 0.477962110880244 0.865522395752796 0.533333333333333 4.3 4 3 no suckling reflex 0.171297777628035 0.477962110880244 0.865522395752796 0.533333333333333 4.3 4 3 joint inflammation 0.171297777628035 0.477962110880244 0.865522395752796 0.533333333333333 4.3 4 3 abnormal pericyte morphology 0.171297777628035 0.477962110880244 0.865522395752796 0.533333333333333 4.3 4 3 abnormal energy homeostasis 0.171297777628035 0.477962110880244 0.865522395752796 0.533333333333333 4.3 4 3 ostium primum atrial septal defect 0.171297777628035 0.477962110880244 0.865522395752796 0.533333333333333 4.3 4 3 decreased trabecular bone mass 0.171297777628035 0.477962110880244 0.865522395752796 0.533333333333333 4.3 4 3 abnormal branching involved in lung morphogenesis 0.171297777628035 0.477962110880244 0.865522395752796 0.533333333333333 4.3 4 3 decreased circulating HDL cholesterol level 0.000391954069939832 0.00494916623845346 0.862141448894387 0.53125 4.3 4 3 abnormal lens morphology 0.000391954069939832 0.00494916623845346 0.862141448894387 0.53125 4.3 4 3 polydipsia 0.0604023723881297 0.256839147547817 0.862141448894387 0.53125 4.3 4 3 abnormal gait 6.07552494706727e-08 2.0845335594248e-06 0.86132083072487 0.530744336569579 4.3 4 3 increased circulating LDL cholesterol level 0.0236837255994803 0.129109689417104 0.861106465162221 0.530612244897959 4.3 4 3 decreased litter size 2.56024160806715e-07 7.5368059172391e-06 0.860517150581628 0.530249110320285 4.3 4 3 postnatal lethality 6.68845083050631e-05 0.00111287768835347 0.860308405416936 0.530120481927711 4.3 4 3 increased width of hypertrophic chondrocyte zone 0.0561613270175538 0.240864311993388 0.859158260489908 0.529411764705882 4.3 4 3 abnormal nervous system development 0.0561613270175538 0.240864311993388 0.859158260489908 0.529411764705882 4.3 4 3 decreased cytotoxic T cell cytolysis 0.0561613270175538 0.240864311993388 0.859158260489908 0.529411764705882 4.3 4 3 abnormal cranial suture morphology 0.156634467073625 0.447414734088377 0.859158260489908 0.529411764705882 4.3 4 3 absence seizures 0.156634467073625 0.447414734088377 0.859158260489908 0.529411764705882 4.3 4 3 abnormal involuntary movement 0.156634467073625 0.447414734088377 0.859158260489908 0.529411764705882 4.3 4 3 abnormal tarsal bone morphology 0.156634467073625 0.447414734088377 0.859158260489908 0.529411764705882 4.3 4 3 enhanced behavioral response to cocaine 0.156634467073625 0.447414734088377 0.859158260489908 0.529411764705882 4.3 4 3 increased trabecular bone mass 0.156634467073625 0.447414734088377 0.859158260489908 0.529411764705882 4.3 4 3 cardiac fibrosis 0.00383322702562996 0.0316257121932156 0.859158260489908 0.529411764705882 4.3 4 3 abnormal dendritic spine morphology 0.0221449227729298 0.123510079366957 0.859158260489908 0.529411764705882 4.3 4 3 abnormal limb bone morphology 0.052238267005299 0.238892408867074 0.856506537463705 0.527777777777778 4.3 4 3 increased thermal nociceptive threshold 0.00317597328886275 0.0267351389375502 0.856011160634634 0.527472527472527 4.3 4 3 postnatal lethality, incomplete penetrance 1.05506941354088e-12 8.33169894026332e-11 0.854284318871323 0.526408450704225 4.3 4 3 abnormal cardiovascular system physiology 0.00046234546181694 0.00565655257352205 0.854133943177102 0.526315789473684 4.3 4 3 abnormal frontal bone morphology 0.0486073975757674 0.223495196801703 0.854133943177102 0.526315789473684 4.3 4 3 shiny skin 0.14356633393225 0.445628421533292 0.854133943177102 0.526315789473684 4.3 4 3 abnormal metatarsal bone morphology 0.14356633393225 0.445628421533292 0.854133943177102 0.526315789473684 4.3 4 3 abnormal optic vesicle formation 0.14356633393225 0.445628421533292 0.854133943177102 0.526315789473684 4.3 4 3 osteoarthritis 0.14356633393225 0.445628421533292 0.854133943177102 0.526315789473684 4.3 4 3 absent amnion 0.14356633393225 0.445628421533292 0.854133943177102 0.526315789473684 4.3 4 3 decreased eye pigmentation 0.14356633393225 0.445628421533292 0.854133943177102 0.526315789473684 4.3 4 3 increased liver cholesterol level 0.14356633393225 0.445628421533292 0.854133943177102 0.526315789473684 4.3 4 3 abnormal kidney morphology 6.98282777511195e-05 0.00115413847778013 0.853157790099185 0.525714285714286 4.3 4 3 abnormal heart ventricle morphology 0.00660031846251962 0.0485748289216495 0.853038899660208 0.525641025641026 4.3 4 3 increased hemoglobin content 0.0169413217457399 0.103288082947373 0.852686258527649 0.525423728813559 4.3 4 3 abnormal male meiosis 0.0158477991123844 0.0973367908445834 0.851333504019144 0.524590163934426 4.3 4 3 increased blood urea nitrogen level 0.000320416901700247 0.00418392148545598 0.850599595826024 0.524137931034483 4.3 4 3 decreased inflammatory response 0.00544298019573455 0.041723923688412 0.850066638685782 0.523809523809524 4.3 4 3 abnormal muscle morphology 0.0421299340915358 0.197360096144436 0.850066638685782 0.523809523809524 4.3 4 3 abnormal salivary gland morphology 0.131851417508893 0.445628421533292 0.850066638685782 0.523809523809524 4.3 4 3 abnormal anxiety-related response 0.131851417508893 0.445628421533292 0.850066638685782 0.523809523809524 4.3 4 3 dry skin 0.131851417508893 0.445628421533292 0.850066638685782 0.523809523809524 4.3 4 3 complete atrioventricular septal defect 0.131851417508893 0.445628421533292 0.850066638685782 0.523809523809524 4.3 4 3 microphthalmia 0.000250811449442958 0.00349520157136895 0.848551368385094 0.522875816993464 4.3 4 3 omphalocele 0.0392421326289648 0.191401578263823 0.84831030265544 0.522727272727273 4.3 4 3 decreased sensitivity to induced morbidity/mortality 0.0392421326289648 0.191401578263823 0.84831030265544 0.522727272727273 4.3 4 3 embryonic lethality, incomplete penetrance 0.0392421326289648 0.191401578263823 0.84831030265544 0.522727272727273 4.3 4 3 hyperkeratosis 0.0121475623174449 0.0799393155149316 0.846706691497301 0.521739130434783 4.3 4 3 abnormal cranial nerve morphology 0.121299417476859 0.432281233486658 0.846706691497301 0.521739130434783 4.3 4 3 abnormal circulating insulin level 0.121299417476859 0.432281233486658 0.846706691497301 0.521739130434783 4.3 4 3 failure of embryo implantation 0.121299417476859 0.432281233486658 0.846706691497301 0.521739130434783 4.3 4 3 abnormal regulatory T cell physiology 0.121299417476859 0.432281233486658 0.846706691497301 0.521739130434783 4.3 4 3 abnormal lung morphology 0.00131860489360923 0.0134703477324556 0.845520827783719 0.521008403361345 4.3 4 3 abnormal primitive streak morphology 0.111757244401271 0.403477714728827 0.843884335858976 0.52 4.3 4 3 abnormal keratinocyte physiology 0.111757244401271 0.403477714728827 0.843884335858976 0.52 4.3 4 3 increased liver glycogen level 0.111757244401271 0.403477714728827 0.843884335858976 0.52 4.3 4 3 increased susceptibility to injury 0.0296282063584428 0.157816195538815 0.842635986249718 0.519230769230769 4.3 4 3 short snout 0.00252456908410746 0.0229192175062675 0.841480106981885 0.518518518518518 4.3 4 3 increased exploration in new environment 0.00817606449009459 0.0564159789711798 0.841480106981885 0.518518518518518 4.3 4 3 abnormal skeleton development 0.00817606449009459 0.0564159789711798 0.841480106981885 0.518518518518518 4.3 4 3 enlarged epididymis 0.0952217072715547 0.352214121692182 0.839407495880945 0.517241379310345 4.3 4 3 epidermal hyperplasia 0.0224636647008405 0.125147516110506 0.838474820885521 0.516666666666667 4.3 4 3 abnormal object recognition memory 0.0880360620542801 0.327828898742548 0.837602318470448 0.516129032258065 4.3 4 3 decreased susceptibility to bacterial infection induced morbidity/mortality 0.0880360620542801 0.327828898742548 0.837602318470448 0.516129032258065 4.3 4 3 belly spot 0.0814676387109982 0.307046592869103 0.836015950443042 0.515151515151515 4.3 4 3 dextrocardia 0.0814676387109982 0.307046592869103 0.836015950443042 0.515151515151515 4.3 4 3 dilated heart atrium 0.0814676387109982 0.307046592869103 0.836015950443042 0.515151515151515 4.3 4 3 diarrhea 0.0814676387109982 0.307046592869103 0.836015950443042 0.515151515151515 4.3 4 3 thick epidermis 0.0159702839077889 0.097968141111282 0.834610881618768 0.514285714285714 4.3 4 3 abnormal intestinal goblet cell morphology 0.0754520693099245 0.300059188502698 0.834610881618768 0.514285714285714 4.3 4 3 cochlear outer hair cell degeneration 0.0149252984203484 0.0921257563787012 0.833966891740976 0.513888888888889 4.3 4 3 abnormal retinal pigment epithelium morphology 0.0114044616404087 0.0760552234062111 0.831712927168703 0.5125 4.3 4 3 lethality at weaning, incomplete penetrance 0.0601992132398277 0.256194256516803 0.831218154457716 0.51219512195122 4.3 4 3 abnormal intestinal mucosa morphology 0.0559029464073318 0.240377837836193 0.830297647088438 0.511627906976744 4.3 4 3 abnormal male reproductive system morphology 0.0559029464073318 0.240377837836193 0.830297647088438 0.511627906976744 4.3 4 3 kidney failure 0.0559029464073318 0.240377837836193 0.830297647088438 0.511627906976744 4.3 4 3 lethality at weaning, complete penetrance 0.0519413314191813 0.2383838780539 0.82945896259643 0.511111111111111 4.3 4 3 cardiac hypertrophy 0.00627574805201035 0.046392045406763 0.827986985732905 0.510204081632653 4.3 4 3 impaired balance 0.00550261541958108 0.0421161718652552 0.827337584175467 0.509803921568627 4.3 4 3 increased kidney weight 0.0417824549151737 0.197284383322086 0.827337584175467 0.509803921568627 4.3 4 3 cochlear inner hair cell degeneration 0.0417824549151737 0.197284383322086 0.827337584175467 0.509803921568627 4.3 4 3 abnormal thrombosis 0.0417824549151737 0.197284383322086 0.827337584175467 0.509803921568627 4.3 4 3 abnormal learning/memory/conditioning 0.0362147897011374 0.182912262703714 0.826180468673124 0.509090909090909 4.3 4 3 abnormal joint morphology 0.0362147897011374 0.182912262703714 0.826180468673124 0.509090909090909 4.3 4 3 abnormal thoracic vertebrae morphology 0.0314340483556656 0.166543546932307 0.825180250188047 0.508474576271186 4.3 4 3 abnormal long bone morphology 0.029300059142245 0.156235577955701 0.824729332018546 0.508196721311475 4.3 4 3 skin lesions 0.0273191345051034 0.146457644572079 0.824307043574092 0.507936507936508 4.3 4 3 abnormal motor coordination/ balance 0.00804520139293708 0.0557943034821117 0.819623480826512 0.505050505050505 4.3 4 3 abnormal vertebrae morphology 0.00578014475653669 0.0441046321530215 0.818871532678964 0.504587155963303 4.3 4 3 neonatal lethality, complete penetrance 5.02924045100219e-08 1.74968330375775e-06 0.818545028878056 0.504385964912281 4.3 4 3 abnormal nervous system physiology 0.00474625881310205 0.0370685048589995 0.818483135114057 0.504347826086956 4.3 4 3 hyperglycemia 0.01529506329121 0.0941744305368435 0.811427246018247 0.5 4.3 4 3 cochlear ganglion degeneration 0.0434034745721755 0.200494230266084 0.811427246018247 0.5 4.3 4 3 curly tail 0.0624908194874061 0.26549259346699 0.811427246018247 0.5 4.3 4 3 abnormal astrocyte morphology 0.0725637601856982 0.294533176847443 0.811427246018247 0.5 4.3 4 3 renal interstitial fibrosis 0.0725637601856982 0.294533176847443 0.811427246018247 0.5 4.3 4 3 abnormal female reproductive system morphology 0.0844819336246118 0.317685275723691 0.811427246018247 0.5 4.3 4 3 heart right ventricle hypertrophy 0.0986658716145505 0.363602008357325 0.811427246018247 0.5 4.3 4 3 impaired wound healing 0.0986658716145505 0.363602008357325 0.811427246018247 0.5 4.3 4 3 narrow eye opening 0.0986658716145505 0.363602008357325 0.811427246018247 0.5 4.3 4 3 abnormal ovulation 0.136245473049592 0.445628421533292 0.811427246018247 0.5 4.3 4 3 increased triglyceride level 0.136245473049592 0.445628421533292 0.811427246018247 0.5 4.3 4 3 curly vibrissae 0.161453298715989 0.454315701986451 0.811427246018247 0.5 4.3 4 3 abnormal startle reflex 0.161453298715989 0.454315701986451 0.811427246018247 0.5 4.3 4 3 abnormal vasodilation 0.161453298715989 0.454315701986451 0.811427246018247 0.5 4.3 4 3 abnormal osteoblast morphology 0.161453298715989 0.454315701986451 0.811427246018247 0.5 4.3 4 3 decreased fatty acid level 0.161453298715989 0.454315701986451 0.811427246018247 0.5 4.3 4 3 increased coping response 0.176257314366641 0.489603651018447 0.811427246018247 0.5 4.3 4 3 parakeratosis 0.176257314366641 0.489603651018447 0.811427246018247 0.5 4.3 4 3 abnormal retinal layer morphology 0.176257314366641 0.489603651018447 0.811427246018247 0.5 4.3 4 3 abnormal limb posture 0.176257314366641 0.489603651018447 0.811427246018247 0.5 4.3 4 3 abnormal basement membrane morphology 0.176257314366641 0.489603651018447 0.811427246018247 0.5 4.3 4 3 decreased circulating estradiol level 0.176257314366641 0.489603651018447 0.811427246018247 0.5 4.3 4 3 abnormal basioccipital bone morphology 0.192869030855972 0.527790664746127 0.811427246018247 0.5 4.3 4 3 waved hair 0.192869030855972 0.527790664746127 0.811427246018247 0.5 4.3 4 3 abnormal hyoid bone morphology 0.192869030855972 0.527790664746127 0.811427246018247 0.5 4.3 4 3 abnormal neuron proliferation 0.192869030855972 0.527790664746127 0.811427246018247 0.5 4.3 4 3 abnormal phrenic nerve morphology 0.211635475302454 0.568206416421861 0.811427246018247 0.5 4.3 4 3 abnormal iron level 0.211635475302454 0.568206416421861 0.811427246018247 0.5 4.3 4 3 eye inflammation 0.211635475302454 0.568206416421861 0.811427246018247 0.5 4.3 4 3 abnormal thyroid cartilage morphology 0.211635475302454 0.568206416421861 0.811427246018247 0.5 4.3 4 3 increased circulating glycerol level 0.211635475302454 0.568206416421861 0.811427246018247 0.5 4.3 4 3 absent ureter 0.211635475302454 0.568206416421861 0.811427246018247 0.5 4.3 4 3 jerky movement 0.211635475302454 0.568206416421861 0.811427246018247 0.5 4.3 4 3 abnormal sperm axoneme morphology 0.211635475302454 0.568206416421861 0.811427246018247 0.5 4.3 4 3 megacephaly 0.257641488737836 0.658667218124734 0.811427246018247 0.5 4.3 4 3 abnormal kidney blood vessel morphology 0.257641488737836 0.658667218124734 0.811427246018247 0.5 4.3 4 3 abnormal fluid regulation 0.257641488737836 0.658667218124734 0.811427246018247 0.5 4.3 4 3 absent otoliths 0.257641488737836 0.658667218124734 0.811427246018247 0.5 4.3 4 3 abnormal positive T cell selection 0.257641488737836 0.658667218124734 0.811427246018247 0.5 4.3 4 3 increased circulating growth hormone level 0.257641488737836 0.658667218124734 0.811427246018247 0.5 4.3 4 3 decreased tongue size 0.257641488737836 0.658667218124734 0.811427246018247 0.5 4.3 4 3 increased lung compliance 0.257641488737836 0.658667218124734 0.811427246018247 0.5 4.3 4 3 pulmonary alveolar hemorrhage 0.257641488737836 0.658667218124734 0.811427246018247 0.5 4.3 4 3 abnormal lateral semicircular canal morphology 0.320713809192193 0.680096238575004 0.811427246018247 0.5 4.3 4 3 abnormal mineral level 0.286415534176416 0.680096238575004 0.811427246018247 0.5 4.3 4 3 increased cranium width 0.320713809192193 0.680096238575004 0.811427246018247 0.5 4.3 4 3 amyloidosis 0.286415534176416 0.680096238575004 0.811427246018247 0.5 4.3 4 3 abnormal tracheal ciliated epithelium morphology 0.286415534176416 0.680096238575004 0.811427246018247 0.5 4.3 4 3 abnormal respiratory mechanics 0.320713809192193 0.680096238575004 0.811427246018247 0.5 4.3 4 3 abnormal respiratory function 0.286415534176416 0.680096238575004 0.811427246018247 0.5 4.3 4 3 ketoaciduria 0.320713809192193 0.680096238575004 0.811427246018247 0.5 4.3 4 3 impaired basement membrane formation 0.320713809192193 0.680096238575004 0.811427246018247 0.5 4.3 4 3 increased natural killer cell mediated cytotoxicity 0.320713809192193 0.680096238575004 0.811427246018247 0.5 4.3 4 3 rickets 0.320713809192193 0.680096238575004 0.811427246018247 0.5 4.3 4 3 dilated bile duct 0.286415534176416 0.680096238575004 0.811427246018247 0.5 4.3 4 3 lymphedema 0.320713809192193 0.680096238575004 0.811427246018247 0.5 4.3 4 3 decreased circulating ketone body level 0.286415534176416 0.680096238575004 0.811427246018247 0.5 4.3 4 3 absent ovary 0.286415534176416 0.680096238575004 0.811427246018247 0.5 4.3 4 3 absent seminal vesicle 0.320713809192193 0.680096238575004 0.811427246018247 0.5 4.3 4 3 delayed somite formation 0.286415534176416 0.680096238575004 0.811427246018247 0.5 4.3 4 3 abnormal nucleotide metabolism 0.286415534176416 0.680096238575004 0.811427246018247 0.5 4.3 4 3 increased atrioventricular cushion size 0.320713809192193 0.680096238575004 0.811427246018247 0.5 4.3 4 3 increased left ventricle diastolic pressure 0.320713809192193 0.680096238575004 0.811427246018247 0.5 4.3 4 3 abnormal hindlimb zeugopod morphology 0.320713809192193 0.680096238575004 0.811427246018247 0.5 4.3 4 3 absent pharyngeal arches 0.320713809192193 0.680096238575004 0.811427246018247 0.5 4.3 4 3 abnormal respiratory conducting tube morphology 0.320713809192193 0.680096238575004 0.811427246018247 0.5 4.3 4 3 decreased cochlear inner hair cell number 0.320713809192193 0.680096238575004 0.811427246018247 0.5 4.3 4 3 hematuria 0.286415534176416 0.680096238575004 0.811427246018247 0.5 4.3 4 3 abnormal developmental vascular remodeling 0.320713809192193 0.680096238575004 0.811427246018247 0.5 4.3 4 3 decreased keratinocyte proliferation 0.286415534176416 0.680096238575004 0.811427246018247 0.5 4.3 4 3 hydrometra 0.286415534176416 0.680096238575004 0.811427246018247 0.5 4.3 4 3 abnormal sperm principal piece morphology 0.320713809192193 0.680096238575004 0.811427246018247 0.5 4.3 4 3 protruding tongue 0.320713809192193 0.680096238575004 0.811427246018247 0.5 4.3 4 3 thick aortic valve 0.320713809192193 0.680096238575004 0.811427246018247 0.5 4.3 4 3 increased compact bone area 0.320713809192193 0.680096238575004 0.811427246018247 0.5 4.3 4 3 abnormal respiratory motile cilium morphology 0.286415534176416 0.680096238575004 0.811427246018247 0.5 4.3 4 3 decreased circulating lactate level 0.320713809192193 0.680096238575004 0.811427246018247 0.5 4.3 4 3 increased body length 0.0580413993443004 0.248072132077229 0.811427246018246 0.5 4.3 4 3 abnormal endoderm development 0.106773950404443 0.38944311089597 0.811427246018246 0.5 4.3 4 3 abnormal vision 0.106773950404443 0.38944311089597 0.811427246018246 0.5 4.3 4 3 abnormal heart atrium morphology 0.115669751720431 0.416394366721522 0.811427246018246 0.5 4.3 4 3 absent mandible 0.233016190522643 0.609172647320099 0.811427246018246 0.5 4.3 4 3 abnormal hair follicle orientation 0.233016190522643 0.609172647320099 0.811427246018246 0.5 4.3 4 3 abnormal mouth morphology 0.233016190522643 0.609172647320099 0.811427246018246 0.5 4.3 4 3 disorganized retinal layers 0.233016190522643 0.609172647320099 0.811427246018246 0.5 4.3 4 3 poor circulation 0.233016190522643 0.609172647320099 0.811427246018246 0.5 4.3 4 3 abnormal olfaction 0.233016190522643 0.609172647320099 0.811427246018246 0.5 4.3 4 3 small pancreas 0.233016190522643 0.609172647320099 0.811427246018246 0.5 4.3 4 3 small epididymis 0.233016190522643 0.609172647320099 0.811427246018246 0.5 4.3 4 3 decreased circulating growth hormone level 0.233016190522643 0.609172647320099 0.811427246018246 0.5 4.3 4 3 dystonia 0.233016190522643 0.609172647320099 0.811427246018246 0.5 4.3 4 3 abnormal thoracic cage shape 0.233016190522643 0.609172647320099 0.811427246018246 0.5 4.3 4 3 increased heart left ventricle size 0.233016190522643 0.609172647320099 0.811427246018246 0.5 4.3 4 3 decreased exploration in new environment 0.0175224852171276 0.106051537658406 0.811427246018246 0.5 4.3 4 3 abnormal skin morphology 0.032664018675965 0.168217803213683 0.811427246018246 0.5 4.3 4 3 abnormal cartilage morphology 0.0782684923881197 0.303144373344414 0.811427246018246 0.5 4.3 4 3 abnormal optic nerve morphology 0.0782684923881197 0.303144373344414 0.811427246018246 0.5 4.3 4 3 hyperactivity 2.4965253532555e-06 6.05864079631518e-05 0.809240110584235 0.498652291105121 4.3 4 3 postnatal lethality, complete penetrance 3.28487317870675e-06 7.70860569059722e-05 0.803018673520648 0.494818652849741 4.3 4 3 cyanosis 0.000861340083238627 0.00954380159045027 0.802974878872223 0.494791666666667 4.3 4 3 alopecia 0.015720715115739 0.0966755966635373 0.802885906586476 0.494736842105263 4.3 4 3 decreased liver weight 0.0358660164205789 0.18151925909703 0.799998693257426 0.492957746478873 4.3 4 3 decreased compact bone thickness 0.0412965581698554 0.197284383322086 0.799316391600064 0.492537313432836 4.3 4 3 abnormal motor capabilities/coordination/movement 0.00593551517807739 0.045082729787687 0.799132893805849 0.492424242424242 4.3 4 3 respiratory distress 0.00201759273801449 0.0190104618780721 0.797356253312728 0.491329479768786 4.3 4 3 abnormal facial morphology 0.0591076659656483 0.252412564960601 0.797191680298628 0.491228070175439 4.3 4 3 hypoactivity 8.87542795959006e-06 0.000192817703488911 0.79636095763064 0.490716180371353 4.3 4 3 absent kidney 0.0793719757808709 0.303144373344414 0.794867506303588 0.489795918367347 4.3 4 3 increased circulating triglyceride level 0.00496888145662576 0.0386857359103492 0.794639096100628 0.489655172413793 4.3 4 3 increased circulating glucose level 0.00565765215432861 0.0432362818245543 0.794162836528497 0.48936170212766 4.3 4 3 cleft secondary palate 0.0209702089056305 0.11901752636273 0.794162836528497 0.48936170212766 4.3 4 3 increased sensitivity to induced morbidity/mortality 0.00180614902149811 0.0173414027783129 0.793787523278719 0.489130434782609 4.3 4 3 decreased osteoclast cell number 0.0922895616145405 0.342642215695775 0.793395529440063 0.488888888888889 4.3 4 3 small kidney 0.0257180600303057 0.13817208277621 0.79298571769965 0.488636363636364 4.3 4 3 increased tumor growth/size 0.107608333991073 0.391911758130006 0.791636337578777 0.48780487804878 4.3 4 3 abnormal response to injury 0.116336199885472 0.418188290773282 0.790621419197266 0.487179487179487 4.3 4 3 abnormal circulating hormone level 0.116336199885472 0.418188290773282 0.790621419197266 0.487179487179487 4.3 4 3 kidney cysts 0.0417148496292232 0.197284383322086 0.789496779909645 0.486486486486487 4.3 4 3 increased brown adipose tissue amount 0.125885932480023 0.445628421533292 0.789496779909645 0.486486486486487 4.3 4 3 impaired skeletal muscle contractility 0.125885932480023 0.445628421533292 0.789496779909645 0.486486486486487 4.3 4 3 abnormal artery morphology 0.13635572699371 0.445628421533292 0.788243610417725 0.485714285714286 4.3 4 3 decreased circulating thyroxine level 0.13635572699371 0.445628421533292 0.788243610417725 0.485714285714286 4.3 4 3 cardiovascular system phenotype 0.147859975729308 0.447414734088377 0.786838541593451 0.484848484848485 4.3 4 3 improved glucose tolerance 0.00196837531995518 0.0186172380547092 0.786587636446259 0.48469387755102 4.3 4 3 abnormal postnatal growth/weight/body size 0.160533054379912 0.453007342904176 0.785252173566045 0.483870967741935 4.3 4 3 decreased neuronal precursor cell number 0.160533054379912 0.453007342904176 0.785252173566045 0.483870967741935 4.3 4 3 abnormal podocyte morphology 0.160533054379912 0.453007342904176 0.785252173566045 0.483870967741935 4.3 4 3 respiratory failure 0.00656380170100832 0.0483776495740984 0.784558794163338 0.483443708609272 4.3 4 3 abnormal long bone epiphyseal plate morphology 0.0686034408575442 0.287049720997714 0.784379671150972 0.483333333333333 4.3 4 3 seizures 0.0173875516252156 0.105363056437817 0.78295611457901 0.482456140350877 4.3 4 3 circling 0.0364014901496217 0.183668776363456 0.782788637335249 0.482352941176471 4.3 4 3 abnormal chondrocyte morphology 0.0853968945019812 0.320641169922533 0.781374385054608 0.481481481481481 4.3 4 3 abnormal maxilla morphology 0.0853968945019812 0.320641169922533 0.781374385054608 0.481481481481481 4.3 4 3 abnormal heart valve morphology 0.190054836288211 0.522388293112624 0.781374385054608 0.481481481481481 4.3 4 3 rectal prolapse 0.190054836288211 0.522388293112624 0.781374385054608 0.481481481481481 4.3 4 3 abnormal type II pneumocyte morphology 0.190054836288211 0.522388293112624 0.781374385054608 0.481481481481481 4.3 4 3 cryptorchism 0.190054836288211 0.522388293112624 0.781374385054608 0.481481481481481 4.3 4 3 absent corpus luteum 0.0919512000208283 0.341640941078134 0.780218505786776 0.480769230769231 4.3 4 3 eyelids open at birth 0.0919512000208283 0.341640941078134 0.780218505786776 0.480769230769231 4.3 4 3 decreased respiratory quotient 0.0990617386453968 0.364790636388489 0.778970156177517 0.48 4.3 4 3 abnormal feces composition 0.207326579621882 0.559901010729047 0.778970156177517 0.48 4.3 4 3 abnormal cochlear outer hair cell morphology 0.207326579621882 0.559901010729047 0.778970156177517 0.48 4.3 4 3 abnormal trabecular bone morphology 0.0185574643583191 0.111378875647175 0.777333664252774 0.478991596638655 4.3 4 3 abnormal inner ear morphology 0.115179342815203 0.414929203841879 0.776147800539192 0.478260869565217 4.3 4 3 abnormal sleep pattern 0.115179342815203 0.414929203841879 0.776147800539192 0.478260869565217 4.3 4 3 delayed wound healing 0.115179342815203 0.414929203841879 0.776147800539192 0.478260869565217 4.3 4 3 fragile skeleton 0.226635386515608 0.602842816192469 0.776147800539192 0.478260869565217 4.3 4 3 abnormal blood vessel physiology 0.226635386515608 0.602842816192469 0.776147800539192 0.478260869565217 4.3 4 3 abnormal sacral vertebrae morphology 0.226635386515608 0.602842816192469 0.776147800539192 0.478260869565217 4.3 4 3 abnormal ulna morphology 0.226635386515608 0.602842816192469 0.776147800539192 0.478260869565217 4.3 4 3 abnormal corneal stroma morphology 0.226635386515608 0.602842816192469 0.776147800539192 0.478260869565217 4.3 4 3 increased susceptibility to fungal infection 0.226635386515608 0.602842816192469 0.776147800539192 0.478260869565217 4.3 4 3 abnormal lens development 0.226635386515608 0.602842816192469 0.776147800539192 0.478260869565217 4.3 4 3 abnormal chondrocyte physiology 0.226635386515608 0.602842816192469 0.776147800539192 0.478260869565217 4.3 4 3 increased body weight 0.00198532149336032 0.0187418869629366 0.775202815392432 0.477678571428571 4.3 4 3 increased or absent threshold for auditory brainstem response 0.000509224506495023 0.00614900951410859 0.774927058481093 0.477508650519031 4.3 4 3 abnormal suckling behavior 0.0415474177514999 0.197284383322086 0.774544189381054 0.477272727272727 4.3 4 3 increased vasoconstriction 0.248339588444224 0.644827480433202 0.772787853350711 0.476190476190476 4.3 4 3 increased keratinocyte proliferation 0.248339588444224 0.644827480433202 0.772787853350711 0.476190476190476 4.3 4 3 abnormal maternal nurturing 0.0844200785169471 0.317685275723691 0.771520988017349 0.475409836065574 4.3 4 3 increased circulating insulin level 0.00958173213410173 0.0650329022744285 0.770855883717334 0.475 4.3 4 3 abnormal social investigation 0.0546239880324413 0.238892408867074 0.770855883717334 0.475 4.3 4 3 abnormal circulating amino acid level 0.0975671783693489 0.360353906746482 0.768720548859391 0.473684210526316 4.3 4 3 increased grooming behavior 0.157049476268443 0.447414734088377 0.768720548859391 0.473684210526316 4.3 4 3 hyporesponsive to tactile stimuli 0.157049476268443 0.447414734088377 0.768720548859391 0.473684210526316 4.3 4 3 irregular coat pigmentation 0.272897702535637 0.680096238575004 0.768720548859391 0.473684210526316 4.3 4 3 short vibrissae 0.272897702535637 0.680096238575004 0.768720548859391 0.473684210526316 4.3 4 3 abnormal neural crest cell migration 0.272897702535637 0.680096238575004 0.768720548859391 0.473684210526316 4.3 4 3 abnormal response to novelty 0.272897702535637 0.680096238575004 0.768720548859391 0.473684210526316 4.3 4 3 increased left ventricle weight 0.272897702535637 0.680096238575004 0.768720548859391 0.473684210526316 4.3 4 3 abnormal sternebra morphology 0.272897702535637 0.680096238575004 0.768720548859391 0.473684210526316 4.3 4 3 decreased liver regeneration 0.272897702535637 0.680096238575004 0.768720548859391 0.473684210526316 4.3 4 3 decreased fertilization frequency 0.272897702535637 0.680096238575004 0.768720548859391 0.473684210526316 4.3 4 3 decreased circulating magnesium level 0.272897702535637 0.680096238575004 0.768720548859391 0.473684210526316 4.3 4 3 abnormal intestine morphology 0.0672190273293931 0.283162287014166 0.767566313801044 0.472972972972973 4.3 4 3 abnormal contextual conditioning behavior 0.104956385057484 0.383375929266506 0.767167578053615 0.472727272727273 4.3 4 3 abnormal locomotor activation 0.0470237655990522 0.216413722345314 0.766843331401859 0.472527472527473 4.3 4 3 abnormal epidermis stratum granulosum morphology 0.170078229175064 0.476966849011241 0.766347954572788 0.472222222222222 4.3 4 3 reduced long term depression 0.170078229175064 0.476966849011241 0.766347954572788 0.472222222222222 4.3 4 3 decreased anxiety-related response 0.0252604235321517 0.135860115754005 0.765248459659485 0.471544715447154 4.3 4 3 overexpanded pulmonary alveoli 0.184380887129188 0.510459050343746 0.763696231546585 0.470588235294118 4.3 4 3 thin skin 0.184380887129188 0.510459050343746 0.763696231546585 0.470588235294118 4.3 4 3 distended urinary bladder 0.300911055810659 0.680096238575004 0.763696231546585 0.470588235294118 4.3 4 3 decreased vasoconstriction 0.300911055810659 0.680096238575004 0.763696231546585 0.470588235294118 4.3 4 3 abnormal testis development 0.300911055810659 0.680096238575004 0.763696231546585 0.470588235294118 4.3 4 3 common atrium 0.300911055810659 0.680096238575004 0.763696231546585 0.470588235294118 4.3 4 3 distended abdomen 0.121627728768486 0.432831152091 0.763696231546585 0.470588235294118 4.3 4 3 abnormal response to novel object 0.121627728768486 0.432831152091 0.763696231546585 0.470588235294118 4.3 4 3 increased total body fat amount 0.0218950071491743 0.122253266629789 0.762983828345515 0.470149253731343 4.3 4 3 organ of Corti degeneration 0.131032630806495 0.445628421533292 0.761748026874272 0.469387755102041 4.3 4 3 increased fluid intake 0.131032630806495 0.445628421533292 0.761748026874272 0.469387755102041 4.3 4 3 kidney cortex cysts 0.200118321432395 0.546426261869465 0.760713043142106 0.46875 4.3 4 3 abnormal auditory brainstem response waveform shape 0.200118321432395 0.546426261869465 0.760713043142106 0.46875 4.3 4 3 altered response to myocardial infarction 0.152343994921847 0.447414734088377 0.757332096283697 0.466666666666667 4.3 4 3 abnormal ovarian follicle morphology 0.152343994921847 0.447414734088377 0.757332096283697 0.466666666666667 4.3 4 3 irregular heartbeat 0.152343994921847 0.447414734088377 0.757332096283697 0.466666666666667 4.3 4 3 decreased salivation 0.333192235958912 0.680096238575004 0.757332096283697 0.466666666666667 4.3 4 3 abnormal epidermis stratum spinosum morphology 0.333192235958912 0.680096238575004 0.757332096283697 0.466666666666667 4.3 4 3 abnormal pup retrieval 0.333192235958912 0.680096238575004 0.757332096283697 0.466666666666667 4.3 4 3 abnormal respiratory system morphology 0.333192235958912 0.680096238575004 0.757332096283697 0.466666666666667 4.3 4 3 abnormal cricoid cartilage morphology 0.333192235958912 0.680096238575004 0.757332096283697 0.466666666666667 4.3 4 3 abnormal bronchus morphology 0.333192235958912 0.680096238575004 0.757332096283697 0.466666666666667 4.3 4 3 arthritis 0.333192235958912 0.680096238575004 0.757332096283697 0.466666666666667 4.3 4 3 decreased aggression towards males 0.333192235958912 0.680096238575004 0.757332096283697 0.466666666666667 4.3 4 3 abnormal olfactory nerve morphology 0.333192235958912 0.680096238575004 0.757332096283697 0.466666666666667 4.3 4 3 abnormal neurotransmitter secretion 0.333192235958912 0.680096238575004 0.757332096283697 0.466666666666667 4.3 4 3 herniated liver 0.333192235958912 0.680096238575004 0.757332096283697 0.466666666666667 4.3 4 3 abnormal spatial learning 0.0161731060332661 0.0990901508811561 0.756668352115175 0.466257668711656 4.3 4 3 short femur 0.064525848832745 0.272509421004165 0.756102661062457 0.465909090909091 4.3 4 3 abnormal neuron differentiation 0.0443252526279458 0.204562274419323 0.753468157016943 0.464285714285714 4.3 4 3 abnormal eye development 0.127149006121351 0.445628421533292 0.753468157016943 0.464285714285714 4.3 4 3 abnormal seminal vesicle morphology 0.127149006121351 0.445628421533292 0.753468157016943 0.464285714285714 4.3 4 3 shortened head 0.23668961776168 0.617802124010681 0.753468157016943 0.464285714285714 4.3 4 3 enhanced coordination 0.23668961776168 0.617802124010681 0.753468157016943 0.464285714285714 4.3 4 3 hydronephrosis 0.0737896480378667 0.295812650272673 0.753468157016943 0.464285714285714 4.3 4 3 abnormal coat appearance 0.0997007483927481 0.366872206548759 0.752628170219823 0.463768115942029 4.3 4 3 abnormal cholesterol homeostasis 0.17758488367135 0.492741102211359 0.752054520699838 0.463414634146341 4.3 4 3 palatal shelves fail to meet at midline 0.17758488367135 0.492741102211359 0.752054520699838 0.463414634146341 4.3 4 3 abnormal mandible morphology 0.136716124892784 0.445628421533292 0.751321524090969 0.462962962962963 4.3 4 3 abnormal cranium morphology 0.0327762072763627 0.168217803213683 0.750872973927333 0.462686567164179 4.3 4 3 maternal effect 0.106884705961706 0.389561474109515 0.750872973927333 0.462686567164179 4.3 4 3 no spontaneous movement 0.258017277069917 0.659289138892059 0.749009765555305 0.461538461538462 4.3 4 3 short hair 0.370880784983711 0.680096238575004 0.749009765555305 0.461538461538462 4.3 4 3 abnormal renal/urinary system morphology 0.370880784983711 0.680096238575004 0.749009765555305 0.461538461538462 4.3 4 3 uterus hypoplasia 0.370880784983711 0.680096238575004 0.749009765555305 0.461538461538462 4.3 4 3 tight skin 0.370880784983711 0.680096238575004 0.749009765555305 0.461538461538462 4.3 4 3 excessive scratching 0.370880784983711 0.680096238575004 0.749009765555305 0.461538461538462 4.3 4 3 abnormal digestion 0.370880784983711 0.680096238575004 0.749009765555305 0.461538461538462 4.3 4 3 abnormal soleus morphology 0.370880784983711 0.680096238575004 0.749009765555305 0.461538461538462 4.3 4 3 absent lateral semicircular canal 0.370880784983711 0.680096238575004 0.749009765555305 0.461538461538462 4.3 4 3 abnormal insulin secretion 0.370880784983711 0.680096238575004 0.749009765555305 0.461538461538462 4.3 4 3 muscle fatigue 0.370880784983711 0.680096238575004 0.749009765555305 0.461538461538462 4.3 4 3 abnormal retinal inner plexiform layer morphology 0.370880784983711 0.680096238575004 0.749009765555305 0.461538461538462 4.3 4 3 increased circulating thyroid-stimulating hormone level 0.370880784983711 0.680096238575004 0.749009765555305 0.461538461538462 4.3 4 3 increased renin activity 0.370880784983711 0.680096238575004 0.749009765555305 0.461538461538462 4.3 4 3 abnormal gut flora balance 0.370880784983711 0.680096238575004 0.749009765555305 0.461538461538462 4.3 4 3 decreased cardiac stroke volume 0.370880784983711 0.680096238575004 0.749009765555305 0.461538461538462 4.3 4 3 increased circulating alanine transaminase level 0.0903366295791443 0.336144152697265 0.749009765555304 0.461538461538462 4.3 4 3 small lens 0.19194657031099 0.527005622128684 0.749009765555304 0.461538461538462 4.3 4 3 abnormal iris morphology 0.19194657031099 0.527005622128684 0.749009765555304 0.461538461538462 4.3 4 3 decreased heart rate 0.0653009143518447 0.275485380841658 0.746513066336787 0.46 4.3 4 3 increased white adipose tissue amount 0.207641681365847 0.559901010729047 0.745635847692443 0.459459459459459 4.3 4 3 abnormal breathing pattern 0.207641681365847 0.559901010729047 0.745635847692443 0.459459459459459 4.3 4 3 abnormal hair follicle development 0.207641681365847 0.559901010729047 0.745635847692443 0.459459459459459 4.3 4 3 abnormal humerus morphology 0.207641681365847 0.559901010729047 0.745635847692443 0.459459459459459 4.3 4 3 abnormal cardiovascular system morphology 0.170403254802865 0.477609122616481 0.743808308850059 0.458333333333333 4.3 4 3 abnormal digestive system morphology 0.281789460807592 0.680096238575004 0.743808308850059 0.458333333333333 4.3 4 3 abnormal adrenal gland morphology 0.281789460807592 0.680096238575004 0.743808308850059 0.458333333333333 4.3 4 3 apnea 0.281789460807592 0.680096238575004 0.743808308850059 0.458333333333333 4.3 4 3 abnormal retinal ganglion layer morphology 0.281789460807592 0.680096238575004 0.743808308850059 0.458333333333333 4.3 4 3 short tail 0.0935232641674656 0.346963638503461 0.742993622860081 0.457831325301205 4.3 4 3 impaired adaptive thermogenesis 0.224823127243275 0.601664904806506 0.741876339216683 0.457142857142857 4.3 4 3 reduced long term potentiation 0.0653412561594284 0.275485380841658 0.738978384766617 0.455357142857143 4.3 4 3 increased liver weight 0.0964055483175106 0.356328085348897 0.73766113274386 0.454545454545455 4.3 4 3 abnormal gametogenesis 0.197843497998853 0.540808462936425 0.73766113274386 0.454545454545455 4.3 4 3 abnormal amino acid level 0.197843497998853 0.540808462936425 0.73766113274386 0.454545454545455 4.3 4 3 abnormal circulating lipid level 0.308408150175544 0.680096238575004 0.73766113274386 0.454545454545455 4.3 4 3 failure of palatal shelf elevation 0.308408150175544 0.680096238575004 0.73766113274386 0.454545454545455 4.3 4 3 increased circulating creatine kinase level 0.308408150175544 0.680096238575004 0.73766113274386 0.454545454545455 4.3 4 3 abnormal ear position 0.415651483706148 0.720120673784522 0.73766113274386 0.454545454545455 4.3 4 3 decreased atrioventricular cushion size 0.415651483706148 0.720120673784522 0.73766113274386 0.454545454545455 4.3 4 3 abnormal awl hair morphology 0.415651483706148 0.720120673784522 0.73766113274386 0.454545454545455 4.3 4 3 abnormal stomach epithelium morphology 0.415651483706148 0.720120673784522 0.73766113274386 0.454545454545455 4.3 4 3 abnormal glossopharyngeal ganglion morphology 0.415651483706148 0.720120673784522 0.73766113274386 0.454545454545455 4.3 4 3 abnormal eye distance/ position 0.415651483706148 0.720120673784522 0.73766113274386 0.454545454545455 4.3 4 3 abnormal fear/anxiety-related behavior 0.415651483706148 0.720120673784522 0.73766113274386 0.454545454545455 4.3 4 3 abnormal vestibular ganglion morphology 0.415651483706148 0.720120673784522 0.73766113274386 0.454545454545455 4.3 4 3 fused joints 0.415651483706148 0.720120673784522 0.73766113274386 0.454545454545455 4.3 4 3 abnormal radial glial cell morphology 0.415651483706148 0.720120673784522 0.73766113274386 0.454545454545455 4.3 4 3 dilated renal glomerular capsule 0.415651483706148 0.720120673784522 0.73766113274386 0.454545454545455 4.3 4 3 abnormal platelet aggregation 0.415651483706148 0.720120673784522 0.73766113274386 0.454545454545455 4.3 4 3 abnormal superovulation 0.415651483706148 0.720120673784522 0.73766113274386 0.454545454545455 4.3 4 3 abnormal aorta smooth muscle morphology 0.415651483706148 0.720120673784522 0.73766113274386 0.454545454545455 4.3 4 3 increased subcutaneous adipose tissue amount 0.415651483706148 0.720120673784522 0.73766113274386 0.454545454545455 4.3 4 3 decreased core body temperature 0.415651483706148 0.720120673784522 0.73766113274386 0.454545454545455 4.3 4 3 hypolactation 0.415651483706148 0.720120673784522 0.73766113274386 0.454545454545455 4.3 4 3 abnormal epidermis stratum basale morphology 0.243666942851635 0.633355820630556 0.73766113274386 0.454545454545455 4.3 4 3 single kidney 0.243666942851635 0.633355820630556 0.73766113274386 0.454545454545455 4.3 4 3 decreased sensitivity to xenobiotic induced morbidity/mortality 0.243666942851635 0.633355820630556 0.73766113274386 0.454545454545455 4.3 4 3 decreased cardiac muscle contractility 0.0839862099414628 0.316299314503238 0.733405395439569 0.451923076923077 4.3 4 3 absent mature ovarian follicles 0.264376975139186 0.674154511182702 0.732902028661642 0.451612903225806 4.3 4 3 abnormal eyelid morphology 0.264376975139186 0.674154511182702 0.732902028661642 0.451612903225806 4.3 4 3 abnormal nose morphology 0.264376975139186 0.674154511182702 0.732902028661642 0.451612903225806 4.3 4 3 abnormal eye physiology 0.167282705917832 0.46992177410571 0.730284521416422 0.45 4.3 4 3 impaired ovarian folliculogenesis 0.230229169790712 0.605706038978737 0.730284521416422 0.45 4.3 4 3 increased susceptibility to weight loss 0.230229169790712 0.605706038978737 0.730284521416422 0.45 4.3 4 3 increased urine glucose level 0.338375706637181 0.680096238575004 0.730284521416422 0.45 4.3 4 3 abnormal hair texture 0.338375706637181 0.680096238575004 0.730284521416422 0.45 4.3 4 3 abnormal fibula morphology 0.338375706637181 0.680096238575004 0.730284521416422 0.45 4.3 4 3 abnormal trachea morphology 0.338375706637181 0.680096238575004 0.730284521416422 0.45 4.3 4 3 abnormal lens epithelium morphology 0.338375706637181 0.680096238575004 0.730284521416422 0.45 4.3 4 3 absent placental labyrinth 0.338375706637181 0.680096238575004 0.730284521416422 0.45 4.3 4 3 abnormal response to tactile stimuli 0.338375706637181 0.680096238575004 0.730284521416422 0.45 4.3 4 3 abnormal circulating cytokine level 0.338375706637181 0.680096238575004 0.730284521416422 0.45 4.3 4 3 decreased muscle cell glucose uptake 0.338375706637181 0.680096238575004 0.730284521416422 0.45 4.3 4 3 abnormal epidermis stratum corneum morphology 0.202483022503611 0.552579833766025 0.728628547444956 0.448979591836735 4.3 4 3 abnormal parietal bone morphology 0.287190796291906 0.680096238575004 0.727486496430152 0.448275862068966 4.3 4 3 aphagia 0.287190796291906 0.680096238575004 0.727486496430152 0.448275862068966 4.3 4 3 impaired branching involved in ureteric bud morphogenesis 0.248597275968508 0.64515985808207 0.726013851700536 0.447368421052632 4.3 4 3 abnormal tibia morphology 0.217742215035161 0.583657068857719 0.725105198569497 0.446808510638298 4.3 4 3 short mandible 0.19224190429923 0.527234550104007 0.724488612516292 0.446428571428571 4.3 4 3 enhanced long term potentiation 0.19224190429923 0.527234550104007 0.724488612516292 0.446428571428571 4.3 4 3 lowered ear position 0.372331520217222 0.680096238575004 0.72126866312733 0.444444444444444 4.3 4 3 delayed kidney development 0.372331520217222 0.680096238575004 0.72126866312733 0.444444444444444 4.3 4 3 abnormal uterus morphology 0.268619045697845 0.680096238575004 0.72126866312733 0.444444444444444 4.3 4 3 thick dermal layer 0.372331520217222 0.680096238575004 0.72126866312733 0.444444444444444 4.3 4 3 abnormal white adipose tissue morphology 0.372331520217222 0.680096238575004 0.72126866312733 0.444444444444444 4.3 4 3 absent allantois 0.372331520217222 0.680096238575004 0.72126866312733 0.444444444444444 4.3 4 3 increased circulating renin level 0.372331520217222 0.680096238575004 0.72126866312733 0.444444444444444 4.3 4 3 abnormal body wall morphology 0.372331520217222 0.680096238575004 0.72126866312733 0.444444444444444 4.3 4 3 short radius 0.268619045697845 0.680096238575004 0.72126866312733 0.444444444444444 4.3 4 3 abnormal retinal blood vessel morphology 0.268619045697845 0.680096238575004 0.72126866312733 0.444444444444444 4.3 4 3 atrioventricular block 0.372331520217222 0.680096238575004 0.72126866312733 0.444444444444444 4.3 4 3 abnormal hair follicle morphology 0.182622293338923 0.506153709950496 0.72126866312733 0.444444444444444 4.3 4 3 increased circulating corticosterone level 0.234243100460458 0.612058521423728 0.72126866312733 0.444444444444444 4.3 4 3 wrinkled skin 0.312387229695283 0.680096238575004 0.72126866312733 0.444444444444444 4.3 4 3 abnormal palate morphology 0.312387229695283 0.680096238575004 0.72126866312733 0.444444444444444 4.3 4 3 dehydration 0.173591506206824 0.484090663329008 0.718692703616161 0.442857142857143 4.3 4 3 decreased kidney weight 0.221118066267703 0.592068019204425 0.717801025323833 0.442307692307692 4.3 4 3 decreased body temperature 0.221118066267703 0.592068019204425 0.717801025323833 0.442307692307692 4.3 4 3 increased circulating creatinine level 0.147619430333828 0.447414734088377 0.717075240667288 0.441860465116279 4.3 4 3 obese 0.165110226378388 0.464081003521176 0.71658510037975 0.441558441558442 4.3 4 3 abnormal skin physiology 0.290471723685146 0.680096238575004 0.715965217074923 0.441176470588235 4.3 4 3 abnormal limb morphology 0.176004157540506 0.489603651018447 0.714055976496057 0.44 4.3 4 3 abnormal hindlimb morphology 0.237224108792726 0.618548187234703 0.714055976496057 0.44 4.3 4 3 increased circulating chloride level 0.237224108792726 0.618548187234703 0.714055976496057 0.44 4.3 4 3 abnormal nest building behavior 0.34029601031065 0.680096238575004 0.714055976496057 0.44 4.3 4 3 abnormal vertebrae development 0.34029601031065 0.680096238575004 0.714055976496057 0.44 4.3 4 3 oligodactyly 0.254561406326947 0.653816725078245 0.709998840265966 0.4375 4.3 4 3 abnormal crypts of Lieberkuhn morphology 0.314355928022246 0.680096238575004 0.709998840265966 0.4375 4.3 4 3 abnormal lymphatic vessel morphology 0.314355928022246 0.680096238575004 0.709998840265966 0.4375 4.3 4 3 abnormal lumbar vertebrae morphology 0.314355928022246 0.680096238575004 0.709998840265966 0.4375 4.3 4 3 abnormal intestinal absorption 0.411106937964898 0.720120673784522 0.709998840265966 0.4375 4.3 4 3 abnormal extraembryonic endoderm formation 0.411106937964898 0.720120673784522 0.709998840265966 0.4375 4.3 4 3 decreased cochlear coiling 0.411106937964898 0.720120673784522 0.709998840265966 0.4375 4.3 4 3 impaired muscle relaxation 0.411106937964898 0.720120673784522 0.709998840265966 0.4375 4.3 4 3 bowed radius 0.411106937964898 0.720120673784522 0.709998840265966 0.4375 4.3 4 3 abnormal wound healing 0.411106937964898 0.720120673784522 0.709998840265966 0.4375 4.3 4 3 decreased circulating prolactin level 0.411106937964898 0.720120673784522 0.709998840265966 0.4375 4.3 4 3 decreased adipocyte glucose uptake 0.411106937964898 0.720120673784522 0.709998840265966 0.4375 4.3 4 3 short limbs 0.169085772358369 0.474718802191243 0.708832996521687 0.436781609195402 4.3 4 3 abnormal lens fiber morphology 0.292372821249318 0.680096238575004 0.707398111913343 0.435897435897436 4.3 4 3 abnormal epidermal layer morphology 0.213148474780768 0.571959904009882 0.705588909581084 0.434782608695652 4.3 4 3 abnormal innervation pattern to muscle 0.371310276067803 0.680096238575004 0.705588909581084 0.434782608695652 4.3 4 3 abnormal CNS synaptic transmission 0.162149982634859 0.456018181802386 0.7048761935108 0.434343434343434 4.3 4 3 abnormal incisor morphology 0.241002545493405 0.628071065390095 0.703236946549147 0.433333333333333 4.3 4 3 decreased width of hypertrophic chondrocyte zone 0.315077989950796 0.680096238575004 0.70177491547524 0.432432432432432 4.3 4 3 impaired righting response 0.182258474479955 0.505426928950824 0.700389833405223 0.431578947368421 4.3 4 3 abnormal gluconeogenesis 0.274290613404769 0.680096238575004 0.700054878917703 0.431372549019608 4.3 4 3 abnormal respiration 0.369160438645485 0.680096238575004 0.69550906801564 0.428571428571429 4.3 4 3 absent corpus callosum 0.369160438645485 0.680096238575004 0.69550906801564 0.428571428571429 4.3 4 3 absent atrioventricular cushions 0.455810257168117 0.776860578763748 0.69550906801564 0.428571428571429 4.3 4 3 translucent skin 0.455810257168117 0.776860578763748 0.69550906801564 0.428571428571429 4.3 4 3 increased aggression towards males 0.455810257168117 0.776860578763748 0.69550906801564 0.428571428571429 4.3 4 3 extended life span 0.455810257168117 0.776860578763748 0.69550906801564 0.428571428571429 4.3 4 3 intestinal obstruction 0.455810257168117 0.776860578763748 0.69550906801564 0.428571428571429 4.3 4 3 abnormal voluntary movement 0.455810257168117 0.776860578763748 0.69550906801564 0.428571428571429 4.3 4 3 abnormal hair cuticle 0.455810257168117 0.776860578763748 0.69550906801564 0.428571428571429 4.3 4 3 abnormal decidualization 0.455810257168117 0.776860578763748 0.69550906801564 0.428571428571429 4.3 4 3 abnormal iris pigmentation 0.455810257168117 0.776860578763748 0.69550906801564 0.428571428571429 4.3 4 3 sternebra fusion 0.455810257168117 0.776860578763748 0.69550906801564 0.428571428571429 4.3 4 3 polyuria 0.22900648989459 0.603446656369483 0.69550906801564 0.428571428571429 4.3 4 3 impaired fertilization 0.242816201211226 0.632135322357849 0.69550906801564 0.428571428571429 4.3 4 3 abnormal action potential 0.242816201211226 0.632135322357849 0.69550906801564 0.428571428571429 4.3 4 3 increased food intake 0.216357517098937 0.580258031033536 0.69550906801564 0.428571428571429 4.3 4 3 abnormal associative learning 0.405902795281898 0.720120673784522 0.69550906801564 0.428571428571429 4.3 4 3 abnormal bile salt homeostasis 0.405902795281898 0.720120673784522 0.69550906801564 0.428571428571429 4.3 4 3 abnormal urine homeostasis 0.205269974713335 0.559419947734015 0.693094105973919 0.427083333333333 4.3 4 3 abnormal response/metabolism to endogenous compounds 0.229484514767714 0.60438616250364 0.69268179538143 0.426829268292683 4.3 4 3 decreased susceptibility to injury 0.258267527762284 0.659589810378523 0.692099709839093 0.426470588235294 4.3 4 3 pulmonary hypoplasia 0.314329155053112 0.680096238575004 0.690576379589997 0.425531914893617 4.3 4 3 abnormal innervation 0.314329155053112 0.680096238575004 0.690576379589997 0.425531914893617 4.3 4 3 absent vibrissae 0.366442548674275 0.680096238575004 0.68848372389427 0.424242424242424 4.3 4 3 impaired swimming 0.274655021098603 0.680096238575004 0.68848372389427 0.424242424242424 4.3 4 3 abnormal tail morphology 0.274655021098603 0.680096238575004 0.68848372389427 0.424242424242424 4.3 4 3 abnormal stomach morphology 0.40063374802052 0.713821989674537 0.686592285092362 0.423076923076923 4.3 4 3 abnormal ureter morphology 0.40063374802052 0.713821989674537 0.686592285092362 0.423076923076923 4.3 4 3 corneal opacity 0.274161505228524 0.680096238575004 0.685713165649222 0.422535211267606 4.3 4 3 abnormal reproductive system physiology 0.363427600119732 0.680096238575004 0.683307154541681 0.421052631578947 4.3 4 3 abnormal retinal outer nuclear layer morphology 0.363427600119732 0.680096238575004 0.683307154541681 0.421052631578947 4.3 4 3 flaky skin 0.444647023985648 0.760962829146405 0.683307154541681 0.421052631578947 4.3 4 3 thin dermal layer 0.444647023985648 0.760962829146405 0.683307154541681 0.421052631578947 4.3 4 3 stereotypic behavior 0.444647023985648 0.760962829146405 0.683307154541681 0.421052631578947 4.3 4 3 decreased grooming behavior 0.444647023985648 0.760962829146405 0.683307154541681 0.421052631578947 4.3 4 3 unresponsive to tactile stimuli 0.444647023985648 0.760962829146405 0.683307154541681 0.421052631578947 4.3 4 3 abnormal nasal septum morphology 0.444647023985648 0.760962829146405 0.683307154541681 0.421052631578947 4.3 4 3 abnormal cochlear inner hair cell morphology 0.444647023985648 0.760962829146405 0.683307154541681 0.421052631578947 4.3 4 3 increased circulating VLDL cholesterol level 0.444647023985648 0.760962829146405 0.683307154541681 0.421052631578947 4.3 4 3 thin interventricular septum 0.444647023985648 0.760962829146405 0.683307154541681 0.421052631578947 4.3 4 3 right-sided stomach 0.444647023985648 0.760962829146405 0.683307154541681 0.421052631578947 4.3 4 3 abnormal blood circulation 0.360259655670025 0.680096238575004 0.679334438526904 0.418604651162791 4.3 4 3 abnormal heart left ventricle morphology 0.3069519781443 0.680096238575004 0.676189371681872 0.416666666666667 4.3 4 3 abnormal foregut morphology 0.435253715539382 0.747458486299076 0.676189371681872 0.416666666666667 4.3 4 3 abnormal body weight 0.435253715539382 0.747458486299076 0.676189371681872 0.416666666666667 4.3 4 3 increased stereotypic behavior 0.435253715539382 0.747458486299076 0.676189371681872 0.416666666666667 4.3 4 3 abnormal sensory capabilities/reflexes/nociception 0.435253715539382 0.747458486299076 0.676189371681872 0.416666666666667 4.3 4 3 abnormal superior cervical ganglion morphology 0.507962876227385 0.816779350107059 0.676189371681872 0.416666666666667 4.3 4 3 abnormal enteric nervous system morphology 0.507962876227385 0.816779350107059 0.676189371681872 0.416666666666667 4.3 4 3 abnormal corticospinal tract morphology 0.507962876227385 0.816779350107059 0.676189371681872 0.416666666666667 4.3 4 3 abnormal AMPA-mediated synaptic currents 0.507962876227385 0.816779350107059 0.676189371681872 0.416666666666667 4.3 4 3 increased circulating parathyroid hormone level 0.507962876227385 0.816779350107059 0.676189371681872 0.416666666666667 4.3 4 3 decreased synaptic depression 0.507962876227385 0.816779350107059 0.676189371681872 0.416666666666667 4.3 4 3 abnormal gastrocnemius morphology 0.507962876227385 0.816779350107059 0.676189371681872 0.416666666666667 4.3 4 3 abnormal aorta elastic fiber morphology 0.507962876227385 0.816779350107059 0.676189371681872 0.416666666666667 4.3 4 3 absent tail 0.507962876227385 0.816779350107059 0.676189371681872 0.416666666666667 4.3 4 3 increased fear-related response 0.507962876227385 0.816779350107059 0.676189371681872 0.416666666666667 4.3 4 3 vestibular saccular macula degeneration 0.507962876227385 0.816779350107059 0.676189371681872 0.416666666666667 4.3 4 3 bowed ulna 0.507962876227385 0.816779350107059 0.676189371681872 0.416666666666667 4.3 4 3 stria vascularis degeneration 0.507962876227385 0.816779350107059 0.676189371681872 0.416666666666667 4.3 4 3 decreased cochlear nerve compound action potential 0.507962876227385 0.816779350107059 0.676189371681872 0.416666666666667 4.3 4 3 abnormal palatine bone morphology 0.507962876227385 0.816779350107059 0.676189371681872 0.416666666666667 4.3 4 3 hemoperitoneum 0.507962876227385 0.816779350107059 0.676189371681872 0.416666666666667 4.3 4 3 decreased renal glomerular filtration rate 0.507962876227385 0.816779350107059 0.676189371681872 0.416666666666667 4.3 4 3 impaired behavioral response to cocaine 0.507962876227385 0.816779350107059 0.676189371681872 0.416666666666667 4.3 4 3 increased type II pneumocyte number 0.507962876227385 0.816779350107059 0.676189371681872 0.416666666666667 4.3 4 3 abnormal colon goblet cell morphology 0.507962876227385 0.816779350107059 0.676189371681872 0.416666666666667 4.3 4 3 abnormal nervous system electrophysiology 0.286994206781488 0.680096238575004 0.676189371681872 0.416666666666667 4.3 4 3 deafness 0.282277388082109 0.680096238575004 0.67209125427774 0.414141414141414 4.3 4 3 abnormal middle ear morphology 0.427021362659776 0.734335042942408 0.671525996704756 0.413793103448276 4.3 4 3 abnormal circulating glucose level 0.427021362659776 0.734335042942408 0.671525996704756 0.413793103448276 4.3 4 3 focal hair loss 0.427021362659776 0.734335042942408 0.671525996704756 0.413793103448276 4.3 4 3 abnormal spinal nerve morphology 0.427021362659776 0.734335042942408 0.671525996704756 0.413793103448276 4.3 4 3 decreased retinal photoreceptor cell number 0.427021362659776 0.734335042942408 0.671525996704756 0.413793103448276 4.3 4 3 absent long term depression 0.427021362659776 0.734335042942408 0.671525996704756 0.413793103448276 4.3 4 3 short sternum 0.427021362659776 0.734335042942408 0.671525996704756 0.413793103448276 4.3 4 3 abnormal blood homeostasis 0.277215142739719 0.680096238575004 0.669071588822063 0.412280701754386 4.3 4 3 short maxilla 0.419622126166665 0.723611812020506 0.668234202603262 0.411764705882353 4.3 4 3 impaired synaptic plasticity 0.419622126166665 0.723611812020506 0.668234202603262 0.411764705882353 4.3 4 3 decreased osteoblast cell number 0.419622126166665 0.723611812020506 0.668234202603262 0.411764705882353 4.3 4 3 increased susceptibility to weight gain 0.419622126166665 0.723611812020506 0.668234202603262 0.411764705882353 4.3 4 3 hydroureter 0.488244055472866 0.797095692990413 0.668234202603262 0.411764705882353 4.3 4 3 increased aggression towards mice 0.488244055472866 0.797095692990413 0.668234202603262 0.411764705882353 4.3 4 3 abnormal heart rate 0.488244055472866 0.797095692990413 0.668234202603262 0.411764705882353 4.3 4 3 abnormal duodenum morphology 0.488244055472866 0.797095692990413 0.668234202603262 0.411764705882353 4.3 4 3 aminoaciduria 0.488244055472866 0.797095692990413 0.668234202603262 0.411764705882353 4.3 4 3 abnormal electroretinogram waveform feature 0.488244055472866 0.797095692990413 0.668234202603262 0.411764705882353 4.3 4 3 decreased body fat mass 0.488244055472866 0.797095692990413 0.668234202603262 0.411764705882353 4.3 4 3 abnormal circadian rhythm 0.406595015891092 0.720120673784522 0.663895019469474 0.409090909090909 4.3 4 3 abnormal photoreceptor outer segment morphology 0.406595015891092 0.720120673784522 0.663895019469474 0.409090909090909 4.3 4 3 abnormal basisphenoid bone morphology 0.473399088047835 0.796469551247202 0.663895019469474 0.409090909090909 4.3 4 3 intestinal ulcer 0.473399088047835 0.796469551247202 0.663895019469474 0.409090909090909 4.3 4 3 increased body size 0.473399088047835 0.796469551247202 0.663895019469474 0.409090909090909 4.3 4 3 abnormal long bone hypertrophic chondrocyte zone 0.400744686866529 0.713821989674537 0.662389588586324 0.408163265306122 4.3 4 3 abnormal trigeminal nerve morphology 0.46130322936912 0.785415320366658 0.661162941200053 0.407407407407407 4.3 4 3 thin epidermis 0.46130322936912 0.785415320366658 0.661162941200053 0.407407407407407 4.3 4 3 abnormal bone trabecula morphology 0.46130322936912 0.785415320366658 0.661162941200053 0.407407407407407 4.3 4 3 abnormal depression-related behavior 0.450980008754276 0.771535606448599 0.659284637389825 0.40625 4.3 4 3 abnormal hair growth 0.419452066909513 0.723611812020506 0.655383544860891 0.403846153846154 4.3 4 3 abnormal femur morphology 0.401430494225025 0.714787655250358 0.65398613858187 0.402985074626866 4.3 4 3 increased anxiety-related response 0.328671738461727 0.680096238575004 0.653811881683767 0.402877697841727 4.3 4 3 abnormal excitatory postsynaptic potential 0.386111083010349 0.688495569167199 0.653099978502491 0.402439024390244 4.3 4 3 decreased paired-pulse facilitation 0.515494568884627 0.827819716010658 0.649141796814597 0.4 4.3 4 3 abnormal heart right ventricle morphology 0.515494568884627 0.827819716010658 0.649141796814597 0.4 4.3 4 3 decreased circulating VLDL cholesterol level 0.515494568884627 0.827819716010658 0.649141796814597 0.4 4.3 4 3 nuclear cataracts 0.515494568884627 0.827819716010658 0.649141796814597 0.4 4.3 4 3 abnormal hair cycle 0.484702760475252 0.797095692990413 0.649141796814597 0.4 4.3 4 3 delayed eyelid opening 0.484702760475252 0.797095692990413 0.649141796814597 0.4 4.3 4 3 abnormal lactation 0.484702760475252 0.797095692990413 0.649141796814597 0.4 4.3 4 3 abnormal enteric neuron morphology 0.53755560464092 0.847822434373732 0.649141796814597 0.4 4.3 4 3 hyperpigmentation 0.53755560464092 0.847822434373732 0.649141796814597 0.4 4.3 4 3 abnormal seizure response to electrical stimulation 0.53755560464092 0.847822434373732 0.649141796814597 0.4 4.3 4 3 abnormal zygomatic bone morphology 0.53755560464092 0.847822434373732 0.649141796814597 0.4 4.3 4 3 abnormal cerebral aqueduct morphology 0.53755560464092 0.847822434373732 0.649141796814597 0.4 4.3 4 3 abnormal Muller cell morphology 0.53755560464092 0.847822434373732 0.649141796814597 0.4 4.3 4 3 absent chorion 0.53755560464092 0.847822434373732 0.649141796814597 0.4 4.3 4 3 lactation failure 0.53755560464092 0.847822434373732 0.649141796814597 0.4 4.3 4 3 abnormal excitatory postsynaptic currents 0.426039235096073 0.734335042942408 0.644980631450401 0.397435897435897 4.3 4 3 abnormal enzyme/coenzyme level 0.454179775862824 0.776742655523393 0.643545746842058 0.396551724137931 4.3 4 3 abnormal hair shaft morphology 0.471709045377024 0.794432126185069 0.642379903097778 0.395833333333333 4.3 4 3 abnormal organ of Corti morphology 0.481796261665997 0.797095692990413 0.641593636386521 0.395348837209302 4.3 4 3 abnormal stria vascularis morphology 0.520925035131472 0.835192410499218 0.637549979014337 0.392857142857143 4.3 4 3 myoclonus 0.520925035131472 0.835192410499218 0.637549979014337 0.392857142857143 4.3 4 3 abnormal jaw morphology 0.520925035131472 0.835192410499218 0.637549979014337 0.392857142857143 4.3 4 3 abnormal hormone level 0.520925035131472 0.835192410499218 0.637549979014337 0.392857142857143 4.3 4 3 abnormal cued conditioning behavior 0.48903783010369 0.797095692990413 0.636413526288821 0.392156862745098 4.3 4 3 abnormal food intake 0.477036017099456 0.797095692990413 0.635030018622975 0.391304347826087 4.3 4 3 hypotension 0.539027610034998 0.847822434373732 0.635030018622975 0.391304347826087 4.3 4 3 decreased epididymis weight 0.539027610034998 0.847822434373732 0.635030018622975 0.391304347826087 4.3 4 3 abnormal palatal shelf fusion at midline 0.539027610034998 0.847822434373732 0.635030018622975 0.391304347826087 4.3 4 3 abnormal basicranium morphology 0.539027610034998 0.847822434373732 0.635030018622975 0.391304347826087 4.3 4 3 abnormal hepatocyte physiology 0.539027610034998 0.847822434373732 0.635030018622975 0.391304347826087 4.3 4 3 abnormal colon morphology 0.495165387391055 0.801642630091278 0.632638191810836 0.389830508474576 4.3 4 3 abnormal heart shape 0.562006577908276 0.879576536887259 0.631110080236414 0.388888888888889 4.3 4 3 abnormal retinal rod cell morphology 0.562006577908276 0.879576536887259 0.631110080236414 0.388888888888889 4.3 4 3 blepharoptosis 0.562006577908276 0.879576536887259 0.631110080236414 0.388888888888889 4.3 4 3 acidosis 0.562006577908276 0.879576536887259 0.631110080236414 0.388888888888889 4.3 4 3 decreased activity of thyroid 0.562006577908276 0.879576536887259 0.631110080236414 0.388888888888889 4.3 4 3 decreased heart rate variability 0.562006577908276 0.879576536887259 0.631110080236414 0.388888888888889 4.3 4 3 decreased pulmonary respiratory rate 0.562006577908276 0.879576536887259 0.631110080236414 0.388888888888889 4.3 4 3 abnormal long bone epiphyseal plate proliferative zone 0.505406383999988 0.816779350107059 0.631110080236414 0.388888888888889 4.3 4 3 abnormal eye electrophysiology 0.469655122339066 0.79202505039511 0.630364967981117 0.388429752066116 4.3 4 3 decreased urine osmolality 0.516653139100338 0.829412509527003 0.629270109157008 0.387755102040816 4.3 4 3 hypertension 0.529145194190937 0.847822434373732 0.627011962832281 0.386363636363636 4.3 4 3 abnormal xiphoid process morphology 0.559762042569797 0.878768116688148 0.62417480462942 0.384615384615385 4.3 4 3 thick skin 0.559762042569797 0.878768116688148 0.62417480462942 0.384615384615385 4.3 4 3 abnormal ocular fundus morphology 0.559762042569797 0.878768116688148 0.62417480462942 0.384615384615385 4.3 4 3 pup cannibalization 0.593639183254682 0.879576536887259 0.62417480462942 0.384615384615385 4.3 4 3 abnormal lung interstitium morphology 0.593639183254682 0.879576536887259 0.62417480462942 0.384615384615385 4.3 4 3 anal atresia 0.593639183254682 0.879576536887259 0.62417480462942 0.384615384615385 4.3 4 3 vestibular hair cell degeneration 0.593639183254682 0.879576536887259 0.62417480462942 0.384615384615385 4.3 4 3 small interparietal bone 0.593639183254682 0.879576536887259 0.62417480462942 0.384615384615385 4.3 4 3 hyperalgesia 0.593639183254682 0.879576536887259 0.62417480462942 0.384615384615385 4.3 4 3 increased vascular permeability 0.54321756661534 0.854142665585119 0.62417480462942 0.384615384615385 4.3 4 3 abnormal kidney development 0.535604122858024 0.847822434373732 0.622094221947322 0.383333333333333 4.3 4 3 increased systemic arterial blood pressure 0.545383466587683 0.857277328996437 0.621518741630997 0.382978723404255 4.3 4 3 decreased pancreatic beta cell number 0.559357644059371 0.878768116688148 0.6205031881316 0.382352941176471 4.3 4 3 small ears 0.582935660332459 0.879576536887259 0.618230282680569 0.380952380952381 4.3 4 3 hypoalgesia 0.582935660332459 0.879576536887259 0.618230282680569 0.380952380952381 4.3 4 3 abnormal stapes morphology 0.582935660332459 0.879576536887259 0.618230282680569 0.380952380952381 4.3 4 3 increased bone ossification 0.582935660332459 0.879576536887259 0.618230282680569 0.380952380952381 4.3 4 3 increased retinal apoptosis 0.578310612753065 0.879576536887259 0.615565496979359 0.379310344827586 4.3 4 3 increased insulin secretion 0.576132458909061 0.879576536887259 0.614053051040835 0.378378378378378 4.3 4 3 abnormal autopod morphology 0.575183026868132 0.879576536887259 0.613078363658231 0.377777777777778 4.3 4 3 abnormal tympanic ring morphology 0.613424804646533 0.879576536887259 0.608570434513685 0.375 4.3 4 3 delayed hair appearance 0.613424804646533 0.879576536887259 0.608570434513685 0.375 4.3 4 3 reduced male mating frequency 0.613424804646533 0.879576536887259 0.608570434513685 0.375 4.3 4 3 abnormal digit morphology 0.587686033506767 0.879576536887259 0.608570434513685 0.375 4.3 4 3 abnormal long term potentiation 0.595101920073764 0.879576536887259 0.608570434513685 0.375 4.3 4 3 abnormal primitive streak formation 0.601291946732368 0.879576536887259 0.608570434513685 0.375 4.3 4 3 abnormal epicardium morphology 0.613424804646533 0.879576536887259 0.608570434513685 0.375 4.3 4 3 abnormal pulmonary elastic fiber morphology 0.613424804646533 0.879576536887259 0.608570434513685 0.375 4.3 4 3 decreased ovulation rate 0.601291946732368 0.879576536887259 0.608570434513685 0.375 4.3 4 3 decreased aggression towards mice 0.613424804646533 0.879576536887259 0.608570434513685 0.375 4.3 4 3 bowed tibia 0.613424804646533 0.879576536887259 0.608570434513685 0.375 4.3 4 3 increased circulating estradiol level 0.613424804646533 0.879576536887259 0.608570434513685 0.375 4.3 4 3 abnormal intestinal lipid absorption 0.613424804646533 0.879576536887259 0.608570434513685 0.375 4.3 4 3 loose skin 0.613424804646533 0.879576536887259 0.608570434513685 0.375 4.3 4 3 decreased circulating triiodothyronine level 0.613424804646533 0.879576536887259 0.608570434513685 0.375 4.3 4 3 impaired behavioral response to addictive substance 0.613424804646533 0.879576536887259 0.608570434513685 0.375 4.3 4 3 dilated respiratory conducting tubes 0.613424804646533 0.879576536887259 0.608570434513685 0.375 4.3 4 3 polyphagia 0.615829658732492 0.879576536887259 0.601057219272775 0.37037037037037 4.3 4 3 delayed sexual maturation 0.630466317696476 0.879576536887259 0.597893760223971 0.368421052631579 4.3 4 3 abnormal ear morphology 0.630466317696476 0.879576536887259 0.597893760223971 0.368421052631579 4.3 4 3 decreased germ cell number 0.630466317696476 0.879576536887259 0.597893760223971 0.368421052631579 4.3 4 3 abnormal photoreceptor inner segment morphology 0.630466317696476 0.879576536887259 0.597893760223971 0.368421052631579 4.3 4 3 eyelids fail to open 0.630466317696476 0.879576536887259 0.597893760223971 0.368421052631579 4.3 4 3 abnormal behavioral response to xenobiotic 0.630466317696476 0.879576536887259 0.597893760223971 0.368421052631579 4.3 4 3 decreased liver glycogen level 0.630466317696476 0.879576536887259 0.597893760223971 0.368421052631579 4.3 4 3 decreased threshold for auditory brainstem response 0.624580373187849 0.879576536887259 0.597893760223971 0.368421052631579 4.3 4 3 emphysema 0.632504632492851 0.882172847393309 0.595046647080047 0.366666666666667 4.3 4 3 short humerus 0.637680389021497 0.889124602231591 0.593727253184083 0.365853658536585 4.3 4 3 decreased airway responsiveness 0.645527987352246 0.890105802959374 0.590128906195088 0.363636363636364 4.3 4 3 abnormal tracheal cartilage morphology 0.645527987352246 0.890105802959374 0.590128906195088 0.363636363636364 4.3 4 3 abnormal temporal bone morphology 0.645527987352246 0.890105802959374 0.590128906195088 0.363636363636364 4.3 4 3 head tossing 0.646057669940899 0.890589334429474 0.590128906195088 0.363636363636364 4.3 4 3 abnormal inner ear vestibule morphology 0.659079312317648 0.904030763380286 0.584227617133137 0.36 4.3 4 3 diaphragmatic hernia 0.659079312317648 0.904030763380286 0.584227617133137 0.36 4.3 4 3 abnormal interparietal bone morphology 0.67021080885833 0.91626786866452 0.579590890013033 0.357142857142857 4.3 4 3 irregularly shaped pupil 0.67021080885833 0.91626786866452 0.579590890013033 0.357142857142857 4.3 4 3 abnormal placing response 0.67021080885833 0.91626786866452 0.579590890013033 0.357142857142857 4.3 4 3 abnormal endplate potential 0.67021080885833 0.91626786866452 0.579590890013033 0.357142857142857 4.3 4 3 abnormal kidney medulla morphology 0.67021080885833 0.91626786866452 0.579590890013033 0.357142857142857 4.3 4 3 decreased coping response 0.67021080885833 0.91626786866452 0.579590890013033 0.357142857142857 4.3 4 3 decreased vascular permeability 0.67021080885833 0.91626786866452 0.579590890013033 0.357142857142857 4.3 4 3 abnormal uterus development 0.67021080885833 0.91626786866452 0.579590890013033 0.357142857142857 4.3 4 3 abnormal imprinting 0.67021080885833 0.91626786866452 0.579590890013033 0.357142857142857 4.3 4 3 premature hair loss 0.67021080885833 0.91626786866452 0.579590890013033 0.357142857142857 4.3 4 3 decreased cornea thickness 0.67021080885833 0.91626786866452 0.579590890013033 0.357142857142857 4.3 4 3 abnormal respiratory motile cilium physiology 0.67021080885833 0.91626786866452 0.579590890013033 0.357142857142857 4.3 4 3 increased circulating luteinizing hormone level 0.671431189500204 0.917432070245404 0.579590890013033 0.357142857142857 4.3 4 3 decreased circulating progesterone level 0.671431189500204 0.917432070245404 0.579590890013033 0.357142857142857 4.3 4 3 abnormal vibrissa morphology 0.680962134602725 0.930192933653705 0.579590890013033 0.357142857142857 4.3 4 3 abnormal cartilage development 0.691105282331162 0.942502406687919 0.577014930501864 0.355555555555556 4.3 4 3 abnormal intestine physiology 0.682801268532993 0.931433043858415 0.575851593948433 0.354838709677419 4.3 4 3 abnormal phalanx morphology 0.700653099984641 0.95395434384882 0.574760965929591 0.354166666666667 4.3 4 3 abnormal vagus nerve morphology 0.681705213286715 0.930192933653705 0.572772173659939 0.352941176470588 4.3 4 3 nephrocalcinosis 0.681705213286715 0.930192933653705 0.572772173659939 0.352941176470588 4.3 4 3 decreased growth hormone level 0.681705213286715 0.930192933653705 0.572772173659939 0.352941176470588 4.3 4 3 abnormal tendon morphology 0.681705213286715 0.930192933653705 0.572772173659939 0.352941176470588 4.3 4 3 abnormal retinal photoreceptor morphology 0.693348593149005 0.944267520097537 0.572772173659939 0.352941176470588 4.3 4 3 abnormal bone remodeling 0.693348593149005 0.944267520097537 0.572772173659939 0.352941176470588 4.3 4 3 abnormal dopamine level 0.692374182441317 0.943457013871694 0.567999072212773 0.35 4.3 4 3 abnormal male reproductive system physiology 0.692374182441317 0.943457013871694 0.567999072212773 0.35 4.3 4 3 abnormal incus morphology 0.692374182441317 0.943457013871694 0.567999072212773 0.35 4.3 4 3 head bobbing 0.712429153291822 0.968133034041741 0.567999072212773 0.35 4.3 4 3 abnormal skin pigmentation 0.712429153291822 0.968133034041741 0.567999072212773 0.35 4.3 4 3 abnormal carpal bone morphology 0.702328188588111 0.955450571021563 0.564471127664867 0.347826086956522 4.3 4 3 bidirectional circling 0.702328188588111 0.955450571021563 0.564471127664867 0.347826086956522 4.3 4 3 abnormal crista ampullaris morphology 0.702328188588111 0.955450571021563 0.564471127664867 0.347826086956522 4.3 4 3 abnormal kidney cortex morphology 0.711659043360628 0.967615124547452 0.561757324166478 0.346153846153846 4.3 4 3 small seminal vesicle 0.711659043360628 0.967615124547452 0.561757324166478 0.346153846153846 4.3 4 3 increased percent body fat/body weight 0.744576542892615 0.970505991281546 0.561757324166478 0.346153846153846 4.3 4 3 stomach inflammation 0.72044201936712 0.970505991281546 0.559604997253963 0.344827586206897 4.3 4 3 increased dopamine level 0.728739022487827 0.970505991281546 0.557856231637544 0.34375 4.3 4 3 abnormal diaphragm morphology 0.728739022487827 0.970505991281546 0.557856231637544 0.34375 4.3 4 3 short ulna 0.751187771802361 0.970505991281546 0.554145436305144 0.341463414634146 4.3 4 3 abnormal axon extension 0.770693968276875 0.97936206696742 0.551770527292408 0.34 4.3 4 3 abnormal stomach glandular epithelium morphology 0.741554530975935 0.970505991281546 0.540951497345498 0.333333333333333 4.3 4 3 abnormal metanephric mesenchyme morphology 0.741554530975935 0.970505991281546 0.540951497345498 0.333333333333333 4.3 4 3 head tilt 0.775626917872187 0.985378936775825 0.540951497345498 0.333333333333333 4.3 4 3 abnormal malleus morphology 0.752846309515983 0.970505991281546 0.540951497345498 0.333333333333333 4.3 4 3 decreased chondrocyte number 0.736538410967034 0.970505991281546 0.540951497345498 0.333333333333333 4.3 4 3 vagina atresia 0.736538410967034 0.970505991281546 0.540951497345498 0.333333333333333 4.3 4 3 increased alcohol consumption 0.736538410967034 0.970505991281546 0.540951497345498 0.333333333333333 4.3 4 3 dilated ureter 0.736538410967034 0.970505991281546 0.540951497345498 0.333333333333333 4.3 4 3 abnormal ear development 0.736538410967034 0.970505991281546 0.540951497345498 0.333333333333333 4.3 4 3 abnormal rostral migratory stream morphology 0.736538410967034 0.970505991281546 0.540951497345498 0.333333333333333 4.3 4 3 abnormal secondary palate development 0.736538410967034 0.970505991281546 0.540951497345498 0.333333333333333 4.3 4 3 abnormal aorta wall morphology 0.736538410967034 0.970505991281546 0.540951497345498 0.333333333333333 4.3 4 3 enhanced paired-pulse facilitation 0.764410712804255 0.971874085407914 0.540951497345498 0.333333333333333 4.3 4 3 abnormal middle ear ossicle morphology 0.770079698761291 0.978831502641141 0.540951497345498 0.333333333333333 4.3 4 3 decreased cochlear outer hair cell number 0.747093443495746 0.970505991281546 0.540951497345498 0.333333333333333 4.3 4 3 decreased food intake 0.858379361619169 1 0.534104010037327 0.329113924050633 4.3 4 3 abnormal forelimb morphology 0.821445167713149 1 0.529191682185813 0.326086956521739 4.3 4 3 increased susceptibility to pharmacologically induced seizures 0.901532236416733 1 0.524046763053451 0.322916666666667 4.3 4 3 abnormal energy expenditure 0.796971955256375 1 0.519313437451678 0.32 4.3 4 3 decreased cardiac output 0.794490656362713 1 0.516362792920702 0.318181818181818 4.3 4 3 abnormal pancreatic alpha cell morphology 0.792499141112717 1 0.507142028761404 0.3125 4.3 4 3 abnormal fertilization 0.792499141112717 1 0.507142028761404 0.3125 4.3 4 3 decreased skeletal muscle weight 0.792499141112717 1 0.507142028761404 0.3125 4.3 4 3 abnormal Schwann cell morphology 0.834888804987818 1 0.499339843703536 0.307692307692308 4.3 4 3 abnormal systemic arterial blood pressure 0.866799317557624 1 0.49587220590004 0.305555555555556 4.3 4 3 syndactyly 0.911574404986853 1 0.495108150112828 0.305084745762712 4.3 4 3 abnormal cochlear ganglion morphology 0.834811736014101 1 0.493912236706759 0.304347826086957 4.3 4 3 increased susceptibility to age related obesity 0.834811736014101 1 0.493912236706759 0.304347826086957 4.3 4 3 brain inflammation 0.835876798993711 1 0.486856347610948 0.3 4.3 4 3 abnormal estrous cycle 0.86631991439328 1 0.486856347610948 0.3 4.3 4 3 abnormal hearing physiology 0.835876798993711 1 0.486856347610948 0.3 4.3 4 3 abnormal pain threshold 0.86631991439328 1 0.486856347610948 0.3 4.3 4 3 abnormal synaptic transmission 0.86631991439328 1 0.486856347610948 0.3 4.3 4 3 enhanced behavioral response to xenobiotic 0.835876798993711 1 0.486856347610948 0.3 4.3 4 3 abnormal digestive system physiology 0.910030252935593 1 0.486856347610948 0.3 4.3 4 3 abnormal cochlea morphology 0.925274922085972 1 0.48084577541822 0.296296296296296 4.3 4 3 decreased susceptibility to pharmacologically induced seizures 0.866989746336265 1 0.48084577541822 0.296296296296296 4.3 4 3 abnormal touch/ nociception 0.838663277706884 1 0.477310144716616 0.294117647058824 4.3 4 3 abnormal inhibitory postsynaptic currents 0.948020196318579 1 0.477310144716616 0.294117647058824 4.3 4 3 abnormal cardiac muscle contractility 0.86856220574862 1 0.47333256017731 0.291666666666667 4.3 4 3 abnormal cranial ganglia morphology 0.892112098626857 1 0.471151304139627 0.290322580645161 4.3 4 3 decreased vocalization 0.871390141192897 1 0.463672712010426 0.285714285714286 4.3 4 3 abnormal axon guidance 0.940677885423678 1 0.452889625684603 0.27906976744186 4.3 4 3 abnormal anterior eye segment morphology 0.876012795680327 1 0.450792914454581 0.277777777777778 4.3 4 3 abnormal nail morphology 0.90572236055616 1 0.427066971588551 0.263157894736842 4.3 4 3 abnormal neurotransmitter level 0.90572236055616 1 0.427066971588551 0.263157894736842 4.3 4 3 maternal imprinting 0.90572236055616 1 0.427066971588551 0.263157894736842 4.3 4 3 abnormal single cell response 0.937292595827614 1 0.420740053490943 0.259259259259259 4.3 4 3 abnormal reflex 0.966960378851863 1 0.405713623009123 0.25 4.3 4 3 abnormal heart electrocardiography waveform feature 0.92900421441031 1 0.405713623009123 0.25 4.3 4 3 impaired conditioned place preference behavior 0.955828562012816 1 0.389485078088758 0.24 4.3 4 3 abnormal stomach mucosa morphology 0.955828562012816 1 0.389485078088758 0.24 4.3 4 3 abnormal tectorial membrane morphology 0.96685735127326 1 0.374504882777652 0.230769230769231 4.3 4 3 impaired behavioral response to xenobiotic 0.982200547285031 1 0.370938169608341 0.228571428571429 4.3 4 3 abnormal cochlear sensory epithelium morphology 0.960767778257379 1 0.36883056637193 0.227272727272727 4.3 4 3 abnormal channel response 0.960767778257379 1 0.36883056637193 0.227272727272727 4.3 4 3 abnormal body temperature homeostasis 0.978991977201612 1 0.366451014330821 0.225806451612903 4.3 4 3 abnormal serotonin level 0.984272728680343 1 0.354999420132983 0.21875 4.3 4 3 blistering 0.971171231563966 1 0.352794454790542 0.217391304347826 4.3 4 3 decreased activated T cell number 6.71657520635086e-05 0.00154698896535165 2.9446511627907 1 4.2 4 2 abnormal hypersensitivity reaction 6.71657520635086e-05 0.00154698896535165 2.9446511627907 1 4.2 4 2 abnormal immature B cell morphology 0.000265083544157561 0.00489123166289244 2.9446511627907 1 4.2 4 2 decreased macrophage nitric oxide production 0.000265083544157561 0.00489123166289244 2.9446511627907 1 4.2 4 2 increased CD4-positive, alpha-beta memory T cell number 0.00104611619945088 0.0148274304623024 2.9446511627907 1 4.2 4 2 abnormal B cell proliferation 2.54848919306219e-06 9.05623838248887e-05 2.69926356589147 0.916666666666667 4.2 4 2 decreased transitional stage T2 B cell number 3.3280829875789e-05 0.00087143225595816 2.65018604651163 0.9 4.2 4 2 decreased transitional stage T1 B cell number 0.000118663313525489 0.00252286318286028 2.6174677002584 0.888888888888889 4.2 4 2 decreased B cell proliferation 2.42949572400481e-32 2.01445687115399e-29 2.60918457462467 0.886075949367089 4.2 4 2 pleural effusion 0.00041820913847133 0.0072242724440794 2.57656976744186 0.875 4.2 4 2 increased brain apoptosis 0.00041820913847133 0.0072242724440794 2.57656976744186 0.875 4.2 4 2 increased B-1 B cell number 3.74465245739682e-06 0.000125031181043954 2.52398671096346 0.857142857142857 4.2 4 2 cellular necrosis 0.00145259029672188 0.0193027305311225 2.52398671096346 0.857142857142857 4.2 4 2 abnormal circulating alanine transaminase level 0.00145259029672188 0.0193027305311225 2.52398671096346 0.857142857142857 4.2 4 2 abnormal MHC II cell surface expression on macrophages 0.00145259029672188 0.0193027305311225 2.52398671096346 0.857142857142857 4.2 4 2 abnormal sperm annulus morphology 0.00145259029672188 0.0193027305311225 2.52398671096346 0.857142857142857 4.2 4 2 decreased DN2 thymocyte number 0.00145259029672188 0.0193027305311225 2.52398671096346 0.857142857142857 4.2 4 2 decreased brain cholesterol level 0.00145259029672188 0.0193027305311225 2.52398671096346 0.857142857142857 4.2 4 2 abnormal Peyer's patch follicle morphology 4.12152554037479e-07 1.78300778811866e-05 2.45387596899225 0.833333333333333 4.2 4 2 altered tumor susceptibility 4.27333965478181e-05 0.00104215023443821 2.45387596899225 0.833333333333333 4.2 4 2 absent ectoplacental cone 0.00495127947591749 0.0493639587027846 2.45387596899225 0.833333333333333 4.2 4 2 abnormal lymph node cortex morphology 0.00495127947591749 0.0493639587027846 2.45387596899225 0.833333333333333 4.2 4 2 extremity edema 0.00495127947591749 0.0493639587027846 2.45387596899225 0.833333333333333 4.2 4 2 decreased liver function 0.00495127947591749 0.0493639587027846 2.45387596899225 0.833333333333333 4.2 4 2 impaired granulocyte bactericidal activity 0.00495127947591749 0.0493639587027846 2.45387596899225 0.833333333333333 4.2 4 2 absent brachial lymph nodes 0.00495127947591749 0.0493639587027846 2.45387596899225 0.833333333333333 4.2 4 2 increased transitional stage T1 B cell number 0.00495127947591749 0.0493639587027846 2.45387596899225 0.833333333333333 4.2 4 2 thymus cortex atrophy 0.00495127947591749 0.0493639587027846 2.45387596899225 0.833333333333333 4.2 4 2 abnormal vertebral artery origin 0.00495127947591749 0.0493639587027846 2.45387596899225 0.833333333333333 4.2 4 2 abnormal lymphocyte physiology 5.76109953347576e-16 9.24563554162642e-14 2.43253791708797 0.826086956521739 4.2 4 2 abnormal thrombopoiesis 0.000141437682431993 0.00290765483512051 2.4092600422833 0.818181818181818 4.2 4 2 abnormal B cell differentiation 5.55634357657154e-29 3.07142325482704e-26 2.39455149501661 0.813186813186813 4.2 4 2 increased fibroblast apoptosis 5.27529723329582e-11 4.1007193336948e-09 2.39252906976744 0.8125 4.2 4 2 absent inguinal lymph nodes 0.000460193248124287 0.00758099804443154 2.35572093023256 0.8 4.2 4 2 acanthocytosis 0.000460193248124287 0.00758099804443154 2.35572093023256 0.8 4.2 4 2 decreased macrophage cytokine production 0.000460193248124287 0.00758099804443154 2.35572093023256 0.8 4.2 4 2 decreased macrophage apoptosis 0.000460193248124287 0.00758099804443154 2.35572093023256 0.8 4.2 4 2 abnormal lymph node B cell domain morphology 1.43624001321644e-05 0.000419980927451928 2.35572093023256 0.8 4.2 4 2 decreased B-1 B cell number 2.09089003079676e-12 1.96267507607809e-10 2.34062015503876 0.794871794871795 4.2 4 2 abnormal spleen periarteriolar lymphoid sheath morphology 4.56642966128711e-05 0.00110281493033512 2.31365448504983 0.785714285714286 4.2 4 2 decreased response to antigen 4.56642966128711e-05 0.00110281493033512 2.31365448504983 0.785714285714286 4.2 4 2 abnormal thymus cortex morphology 4.68739031131829e-06 0.000153419518413214 2.2902842377261 0.777777777777778 4.2 4 2 decreased level of surface class I molecules 0.00146661952578177 0.0193027305311225 2.2902842377261 0.777777777777778 4.2 4 2 increased pheochromocytoma incidence 0.00146661952578177 0.0193027305311225 2.2902842377261 0.777777777777778 4.2 4 2 abnormal gut-associated lymphoid tissue morphology 0.00146661952578177 0.0193027305311225 2.2902842377261 0.777777777777778 4.2 4 2 absent cervical lymph nodes 0.00146661952578177 0.0193027305311225 2.2902842377261 0.777777777777778 4.2 4 2 decreased platelet dense granule number 0.00146661952578177 0.0193027305311225 2.2902842377261 0.777777777777778 4.2 4 2 decreased IgM level 9.80905845583325e-26 4.06667215148087e-23 2.246434907696 0.762886597938144 4.2 4 2 abnormal humoral immune response 1.21806542516629e-27 6.05987549020228e-25 2.24354374307863 0.761904761904762 4.2 4 2 arrested B cell differentiation 2.1760084661935e-11 1.77469542939552e-09 2.22644356211004 0.75609756097561 4.2 4 2 abnormal vascular endothelial cell development 0.000437550540084516 0.0074804602643315 2.20848837209302 0.75 4.2 4 2 increased sensitivity to skin irradiation 0.00455573377147354 0.0465395801089956 2.20848837209302 0.75 4.2 4 2 colon polyps 0.00455573377147354 0.0465395801089956 2.20848837209302 0.75 4.2 4 2 elevated level of mitotic sister chromatid exchange 0.00455573377147354 0.0465395801089956 2.20848837209302 0.75 4.2 4 2 abnormal NK cell morphology 0.00455573377147354 0.0465395801089956 2.20848837209302 0.75 4.2 4 2 increased B cell proliferation 3.12979745177146e-15 4.32520620071195e-13 2.19601103665747 0.745762711864407 4.2 4 2 increased B cell derived lymphoma incidence 7.59333972565869e-13 7.70956431329632e-11 2.17904186046512 0.74 4.2 4 2 abnormal dendritic cell morphology 0.000131744511934815 0.0027539031381332 2.15941085271318 0.733333333333333 4.2 4 2 abnormal sphenoid bone morphology 0.0013102080899704 0.0181063479100076 2.1415644820296 0.727272727272727 4.2 4 2 abnormal megakaryocyte differentiation 3.99846135604367e-05 0.000984769566649369 2.12669250645995 0.722222222222222 4.2 4 2 increased effector memory CD4-positive, alpha-beta T cell number 3.99846135604367e-05 0.000984769566649369 2.12669250645995 0.722222222222222 4.2 4 2 increased effector memory CD8-positive, alpha-beta T cell number 3.99846135604367e-05 0.000984769566649369 2.12669250645995 0.722222222222222 4.2 4 2 spleen hyperplasia 3.09676114618329e-17 6.16255468090474e-15 2.1201488372093 0.72 4.2 4 2 increased pre-B cell number 1.30931441753034e-06 4.89762347910786e-05 2.1201488372093 0.72 4.2 4 2 lymphoid hyperplasia 4.07231715075962e-07 1.77717349342361e-05 2.10332225913621 0.714285714285714 4.2 4 2 increased hemangioma incidence 0.000385475717051417 0.00672891821870456 2.10332225913621 0.714285714285714 4.2 4 2 mammary gland hyperplasia 0.0136980024239065 0.112640598444521 2.10332225913621 0.714285714285714 4.2 4 2 skin photosensitivity 0.0136980024239065 0.112640598444521 2.10332225913621 0.714285714285714 4.2 4 2 increased cell nucleus count 0.0136980024239065 0.112640598444521 2.10332225913621 0.714285714285714 4.2 4 2 abnormal uterus physiology 0.0136980024239065 0.112640598444521 2.10332225913621 0.714285714285714 4.2 4 2 heart hemorrhage 0.0136980024239065 0.112640598444521 2.10332225913621 0.714285714285714 4.2 4 2 increased tumor latency 0.0136980024239065 0.112640598444521 2.10332225913621 0.714285714285714 4.2 4 2 decreased DN4 thymocyte number 0.0136980024239065 0.112640598444521 2.10332225913621 0.714285714285714 4.2 4 2 arteritis 0.0136980024239065 0.112640598444521 2.10332225913621 0.714285714285714 4.2 4 2 decreased T-helper 17 cell number 0.0136980024239065 0.112640598444521 2.10332225913621 0.714285714285714 4.2 4 2 ductus venosus stenosis 0.0136980024239065 0.112640598444521 2.10332225913621 0.714285714285714 4.2 4 2 abnormal T cell proliferation 1.26925838149533e-07 5.90145836256008e-06 2.08975243810953 0.709677419354839 4.2 4 2 decreased B cell number 7.73858493965098e-43 1.92497300373818e-39 2.08698577557011 0.70873786407767 4.2 4 2 pancytopenia 0.000115141001936838 0.00246907967515418 2.07857729138167 0.705882352941177 4.2 4 2 abnormal erythropoiesis 3.53525360021557e-22 1.03458156829838e-19 2.07527796234773 0.704761904761905 4.2 4 2 spleen atrophy 3.4766029916176e-05 0.000895823374413879 2.06125581395349 0.7 4.2 4 2 abnormal thymocyte activation 3.4766029916176e-05 0.000895823374413879 2.06125581395349 0.7 4.2 4 2 enlarged testis 0.00381494750698257 0.0415303366460356 2.06125581395349 0.7 4.2 4 2 abnormal airway responsiveness 0.00381494750698257 0.0415303366460356 2.06125581395349 0.7 4.2 4 2 absent axillary lymph nodes 0.00381494750698257 0.0415303366460356 2.06125581395349 0.7 4.2 4 2 increased circulating fructosamine level 0.00381494750698257 0.0415303366460356 2.06125581395349 0.7 4.2 4 2 decreased trabecular bone connectivity density 0.00381494750698257 0.0415303366460356 2.06125581395349 0.7 4.2 4 2 abnormal B cell morphology 1.05825779853494e-05 0.000316132477379187 2.04845298281092 0.695652173913043 4.2 4 2 increased intestinal adenocarcinoma incidence 0.000324573942347236 0.00578765363146058 2.0244476744186 0.6875 4.2 4 2 abnormal level of surface class II molecules 0.000324573942347236 0.00578765363146058 2.0244476744186 0.6875 4.2 4 2 blepharitis 0.000324573942347236 0.00578765363146058 2.0244476744186 0.6875 4.2 4 2 decreased liver cholesterol level 0.000324573942347236 0.00578765363146058 2.0244476744186 0.6875 4.2 4 2 decreased tumor incidence 9.70933609835951e-05 0.00215642620934547 2.01476132190942 0.684210526315789 4.2 4 2 increased liver adenoma incidence 9.70933609835951e-05 0.00215642620934547 2.01476132190942 0.684210526315789 4.2 4 2 abnormal mesenteric lymph node morphology 2.93482173921919e-05 0.000772994827029911 2.00771670190275 0.681818181818182 4.2 4 2 impaired humoral immune response 2.93482173921919e-05 0.000772994827029911 2.00771670190275 0.681818181818182 4.2 4 2 inner cell mass degeneration 8.43987063060424e-07 3.30616979427213e-05 1.99476369092273 0.67741935483871 4.2 4 2 decreased IgG level 1.02608017858135e-20 2.68670994128538e-18 1.98962916404777 0.675675675675676 4.2 4 2 abnormal leukocyte migration 2.40656512028846e-10 1.76068551079928e-08 1.98197674418605 0.673076923076923 4.2 4 2 myeloid hyperplasia 7.02798361856099e-07 2.81969504051137e-05 1.9631007751938 0.666666666666667 4.2 4 2 embryonic lethality at implantation, complete penetrance 7.98685708616965e-05 0.00180611881834973 1.9631007751938 0.666666666666667 4.2 4 2 abnormal redox activity 0.00026545377868964 0.00489123166289244 1.9631007751938 0.666666666666667 4.2 4 2 myocarditis 0.00305552318974218 0.0349453514229135 1.9631007751938 0.666666666666667 4.2 4 2 interstitial pneumonia 0.00305552318974218 0.0349453514229135 1.9631007751938 0.666666666666667 4.2 4 2 increased osteosarcoma incidence 0.00305552318974218 0.0349453514229135 1.9631007751938 0.666666666666667 4.2 4 2 abnormal vitelline vein connection 0.00305552318974218 0.0349453514229135 1.9631007751938 0.666666666666667 4.2 4 2 heart hyperplasia 0.0107339622628571 0.0938514275179506 1.9631007751938 0.666666666666667 4.2 4 2 distorted hair follicle pattern 0.0107339622628571 0.0938514275179506 1.9631007751938 0.666666666666667 4.2 4 2 decreased cellular sensitivity to ionizing radiation 0.0107339622628571 0.0938514275179506 1.9631007751938 0.666666666666667 4.2 4 2 abnormal leukopoiesis 0.0107339622628571 0.0938514275179506 1.9631007751938 0.666666666666667 4.2 4 2 shortened ST segment 0.0107339622628571 0.0938514275179506 1.9631007751938 0.666666666666667 4.2 4 2 abnormal oxidative phosphorylation 0.0107339622628571 0.0938514275179506 1.9631007751938 0.666666666666667 4.2 4 2 increased myeloid cell number 0.0107339622628571 0.0938514275179506 1.9631007751938 0.666666666666667 4.2 4 2 increased autoantibody level 6.76283652218673e-08 3.35865892107455e-06 1.9631007751938 0.666666666666667 4.2 4 2 macrocytosis 0.000892938127284621 0.0130734647537125 1.9631007751938 0.666666666666667 4.2 4 2 abnormal placenta size 0.000892938127284621 0.0130734647537125 1.9631007751938 0.666666666666667 4.2 4 2 increased T cell proliferation 5.2034756567577e-19 1.17669506328953e-16 1.95392740708542 0.663551401869159 4.2 4 2 decreased T cell proliferation 1.41392286497266e-25 5.41097404095307e-23 1.94983658076681 0.662162162162162 4.2 4 2 increased double-negative T cell number 4.36958965626986e-11 3.45058865713374e-09 1.93091879527259 0.655737704918033 4.2 4 2 abnormal CD8-positive, alpha-beta T cell physiology 6.0509411528546e-06 0.000190528052123112 1.92925421010425 0.655172413793103 4.2 4 2 abnormal cell death 1.43012386067506e-08 8.27310024053306e-07 1.92042467138524 0.652173913043478 4.2 4 2 abnormal Peyer's patch T cell area morphology 0.00021284411868023 0.00407269034782362 1.91402325581395 0.65 4.2 4 2 abnormal ectoplacental cone morphology 0.000708534333099635 0.0107951757649508 1.90536251709986 0.647058823529412 4.2 4 2 abnormal spleen germinal center morphology 1.58161991697817e-05 0.000449631947826651 1.89299003322259 0.642857142857143 4.2 4 2 subcutaneous edema 1.58161991697817e-05 0.000449631947826651 1.89299003322259 0.642857142857143 4.2 4 2 failure of zygotic cell division 0.00238850799862608 0.0283049249248851 1.89299003322259 0.642857142857143 4.2 4 2 vascular smooth muscle hypoplasia 0.00238850799862608 0.0283049249248851 1.89299003322259 0.642857142857143 4.2 4 2 abnormal maternal decidual layer morphology 0.00238850799862608 0.0283049249248851 1.89299003322259 0.642857142857143 4.2 4 2 increased stomach tumor incidence 0.00238850799862608 0.0283049249248851 1.89299003322259 0.642857142857143 4.2 4 2 decreased double-positive T cell number 4.16777421225476e-16 7.14988851929912e-14 1.88457674418605 0.64 4.2 4 2 increased cellular sensitivity to gamma-irradiation 2.99202507321347e-08 1.63574997134473e-06 1.87956457199406 0.638297872340426 4.2 4 2 abnormal cytokine secretion 1.31515099216947e-23 4.6734829900308e-21 1.8738689217759 0.636363636363636 4.2 4 2 increased activated T cell number 0.000168279189433329 0.00332217844218577 1.8738689217759 0.636363636363636 4.2 4 2 intestinal inflammation 0.000168279189433329 0.00332217844218577 1.8738689217759 0.636363636363636 4.2 4 2 decreased susceptibility to viral infection induced morbidity/mortality 0.000168279189433329 0.00332217844218577 1.8738689217759 0.636363636363636 4.2 4 2 increased mammary gland tumor incidence 0.000168279189433329 0.00332217844218577 1.8738689217759 0.636363636363636 4.2 4 2 abnormal large intestine morphology 0.00819824148675386 0.075046080571084 1.8738689217759 0.636363636363636 4.2 4 2 impaired myelopoiesis 0.00819824148675386 0.075046080571084 1.8738689217759 0.636363636363636 4.2 4 2 abnormal dorsal-ventral polarity of the somites 0.00819824148675386 0.075046080571084 1.8738689217759 0.636363636363636 4.2 4 2 abnormal cell cycle 7.14705932038572e-18 1.48152583828829e-15 1.86921334681496 0.634782608695652 4.2 4 2 extramedullary hematopoiesis 2.19925303150433e-16 4.20818608912848e-14 1.86124177270733 0.632075471698113 4.2 4 2 altered susceptibility to infection 0.00055407163761429 0.0088649358563056 1.85977968176255 0.631578947368421 4.2 4 2 abnormal immune system morphology 7.60374295744039e-08 3.70868835424176e-06 1.8564105156724 0.630434782608696 4.2 4 2 impaired macrophage phagocytosis 2.41372575829157e-07 1.07216836138398e-05 1.84896700919416 0.627906976744186 4.2 4 2 impaired hematopoiesis 1.91045662391377e-08 1.09247375907713e-06 1.84762425900593 0.627450980392157 4.2 4 2 small lymph nodes 0.000131681708045895 0.0027539031381332 1.84040697674419 0.625 4.2 4 2 abnormal cellular extravasation 0.000131681708045895 0.0027539031381332 1.84040697674419 0.625 4.2 4 2 large intestinal inflammation 0.00184021176884693 0.0230605882871876 1.84040697674419 0.625 4.2 4 2 impaired somite development 0.00184021176884693 0.0230605882871876 1.84040697674419 0.625 4.2 4 2 abnormal cecum morphology 0.0289351168446282 0.19453000851625 1.84040697674419 0.625 4.2 4 2 abnormal atrial thrombosis 0.0289351168446282 0.19453000851625 1.84040697674419 0.625 4.2 4 2 abnormal hepatobiliary system morphology 0.0289351168446282 0.19453000851625 1.84040697674419 0.625 4.2 4 2 abnormal neuron apoptosis 0.0289351168446282 0.19453000851625 1.84040697674419 0.625 4.2 4 2 increased cardiac output 0.0289351168446282 0.19453000851625 1.84040697674419 0.625 4.2 4 2 abnormal platelet shape 0.0289351168446282 0.19453000851625 1.84040697674419 0.625 4.2 4 2 abnormal eyelid aperture 0.0289351168446282 0.19453000851625 1.84040697674419 0.625 4.2 4 2 binucleate 0.0289351168446282 0.19453000851625 1.84040697674419 0.625 4.2 4 2 abnormal kidney epithelium morphology 0.0289351168446282 0.19453000851625 1.84040697674419 0.625 4.2 4 2 accumulation of giant lysosomes in kidney/renal tubule cells 0.0289351168446282 0.19453000851625 1.84040697674419 0.625 4.2 4 2 abnormal choroid pigmentation 0.0289351168446282 0.19453000851625 1.84040697674419 0.625 4.2 4 2 decreased susceptibility to autoimmune disorder 0.0289351168446282 0.19453000851625 1.84040697674419 0.625 4.2 4 2 abnormal mitotic spindle assembly checkpoint 0.0289351168446282 0.19453000851625 1.84040697674419 0.625 4.2 4 2 abnormal base-excision repair 0.0289351168446282 0.19453000851625 1.84040697674419 0.625 4.2 4 2 decreased hippocampus pyramidal cell number 0.0289351168446282 0.19453000851625 1.84040697674419 0.625 4.2 4 2 myocardial trabeculae hypoplasia 0.0289351168446282 0.19453000851625 1.84040697674419 0.625 4.2 4 2 absent ureteric bud 0.0289351168446282 0.19453000851625 1.84040697674419 0.625 4.2 4 2 abnormal macrophage activation involved in immune response 0.0289351168446282 0.19453000851625 1.84040697674419 0.625 4.2 4 2 decreased cranium length 0.0289351168446282 0.19453000851625 1.84040697674419 0.625 4.2 4 2 decreased vascular endothelial cell proliferation 0.0289351168446282 0.19453000851625 1.84040697674419 0.625 4.2 4 2 increased granulocyte number 2.48386007101512e-11 1.99309739569359e-09 1.83045883092395 0.621621621621622 4.2 4 2 abnormal cytotoxic T cell physiology 6.03990115749217e-07 2.47956352919644e-05 1.82287929125138 0.619047619047619 4.2 4 2 abnormal erythrocyte physiology 0.000428929383885346 0.00735835753389516 1.82287929125138 0.619047619047619 4.2 4 2 enlarged spleen 3.39270283252726e-39 4.21967414795578e-36 1.81995801033592 0.618055555555556 4.2 4 2 decreased lymphocyte cell number 3.72757342862569e-18 8.0629033945273e-16 1.81740188953488 0.6171875 4.2 4 2 abnormal dendritic cell physiology 2.16380611050678e-15 3.16615747052094e-13 1.81632688545968 0.616822429906542 4.2 4 2 decreased IgA level 3.75706510233662e-08 2.03167379175268e-06 1.81209302325581 0.615384615384615 4.2 4 2 decreased Peyer's patch number 0.000102248198640289 0.00226082128104638 1.81209302325581 0.615384615384615 4.2 4 2 increased pituitary adenoma incidence 0.00618300927086187 0.0592225471673703 1.81209302325581 0.615384615384615 4.2 4 2 lymphoid hypoplasia 0.00618300927086187 0.0592225471673703 1.81209302325581 0.615384615384615 4.2 4 2 abnormal coping response 0.00618300927086187 0.0592225471673703 1.81209302325581 0.615384615384615 4.2 4 2 tracheoesophageal fistula 0.00618300927086187 0.0592225471673703 1.81209302325581 0.615384615384615 4.2 4 2 orthokeratosis 0.00618300927086187 0.0592225471673703 1.81209302325581 0.615384615384615 4.2 4 2 impaired natural killer cell mediated cytotoxicity 9.42000741009355e-09 5.57911153157326e-07 1.80811913504692 0.614035087719298 4.2 4 2 abnormal T cell differentiation 2.0854921659963e-14 2.53056671361746e-12 1.80760764448538 0.613861386138614 4.2 4 2 abnormal CD8-positive, alpha beta T cell morphology 2.47396946298851e-05 0.000672568201003707 1.80478619654914 0.612903225806452 4.2 4 2 abnormal thymus medulla morphology 0.00140480377574391 0.0190433209382179 1.79950904392765 0.611111111111111 4.2 4 2 increased gastrointestinal tumor incidence 0.00140480377574391 0.0190433209382179 1.79950904392765 0.611111111111111 4.2 4 2 abnormal aerobic respiration 0.00140480377574391 0.0190433209382179 1.79950904392765 0.611111111111111 4.2 4 2 abnormal hematopoietic stem cell physiology 0.00032966091989403 0.00585736813025999 1.79239635995956 0.608695652173913 4.2 4 2 pale liver 1.18185932420087e-10 8.90871233015047e-09 1.79066624764299 0.608108108108108 4.2 4 2 increased lung adenocarcinoma incidence 9.21004455594998e-08 4.44854093843215e-06 1.78988600091199 0.607843137254902 4.2 4 2 abnormal NK cell physiology 5.77836985279003e-09 3.50577927044273e-07 1.78609988562714 0.60655737704918 4.2 4 2 abnormal T cell subpopulation ratio 1.91523526210931e-05 0.00053230700720636 1.784637068358 0.606060606060606 4.2 4 2 abnormal vasculogenesis 1.15858164739166e-06 4.46817340757635e-05 1.78048674959438 0.604651162790698 4.2 4 2 decreased mean corpuscular hemoglobin 1.13417167123389e-09 7.72945762245012e-08 1.77545143638851 0.602941176470588 4.2 4 2 increased mammary adenocarcinoma incidence 0.00106591291601538 0.0149799908394817 1.76679069767442 0.6 4.2 4 2 abnormal immune cell physiology 0.0211124843966688 0.151542359091996 1.76679069767442 0.6 4.2 4 2 bifid ureter 0.0211124843966688 0.151542359091996 1.76679069767442 0.6 4.2 4 2 absent CD4-positive, alpha beta T cells 0.0211124843966688 0.151542359091996 1.76679069767442 0.6 4.2 4 2 abnormal corneal endothelium morphology 0.0211124843966688 0.151542359091996 1.76679069767442 0.6 4.2 4 2 increased T-helper 17 cell number 0.0211124843966688 0.151542359091996 1.76679069767442 0.6 4.2 4 2 lethality during fetal growth through weaning, complete penetrance 0.0211124843966688 0.151542359091996 1.76679069767442 0.6 4.2 4 2 increased monocyte cell number 2.32530537282588e-13 2.46136047442739e-11 1.76679069767442 0.6 4.2 4 2 abnormal T-helper 2 physiology 5.57081177136816e-08 2.91734616447964e-06 1.76679069767442 0.6 4.2 4 2 abnormal liver development 1.47658593851472e-05 0.000427093897913416 1.76679069767442 0.6 4.2 4 2 spontaneous skin ulceration 0.000252025036394787 0.00476739374929302 1.76679069767442 0.6 4.2 4 2 abnormal microglial cell activation 0.00463186280563827 0.0472203226599393 1.76679069767442 0.6 4.2 4 2 abnormal T-helper 1 physiology 6.92929874715492e-07 2.80270416805656e-05 1.75426026719446 0.595744680851064 4.2 4 2 abnormal spleen white pulp morphology 2.79532192625759e-06 9.79346942474048e-05 1.75276854928018 0.595238095238095 4.2 4 2 abnormal response to infection 1.34470782318048e-10 9.98495734376548e-09 1.75188107153371 0.594936708860759 4.2 4 2 abnormal fetal cardiomyocyte proliferation 0.000191906714174007 0.00372943712115502 1.74497846683893 0.592592592592593 4.2 4 2 abnormal CD4-positive, alpha-beta T cell physiology 1.63147068188226e-09 1.06796929504793e-07 1.74190632165084 0.591549295774648 4.2 4 2 abnormal definitive hematopoiesis 5.18382217592248e-12 4.68900278640261e-10 1.74146036509127 0.591397849462366 4.2 4 2 increased T cell number 2.04320028322924e-11 1.69415356817758e-09 1.74002114164905 0.590909090909091 4.2 4 2 abnormal myelopoiesis 2.14816784503904e-06 7.80082848837169e-05 1.74002114164905 0.590909090909091 4.2 4 2 abnormal lysosome physiology 0.000805424109204924 0.0119611490844612 1.74002114164905 0.590909090909091 4.2 4 2 abnormal vascular branching morphogenesis 0.000805424109204924 0.0119611490844612 1.74002114164905 0.590909090909091 4.2 4 2 increased embryonic tissue cell apoptosis 3.18447134098587e-10 2.29604998860938e-08 1.73658914728682 0.58974358974359 4.2 4 2 decreased bone marrow cell number 1.25971340180315e-09 8.46901915401445e-08 1.73452054794521 0.589041095890411 4.2 4 2 abnormal spleen red pulp morphology 3.54222722627924e-05 0.000899111247486695 1.73214774281806 0.588235294117647 4.2 4 2 increased susceptibility to viral infection induced morbidity/mortality 3.54222722627924e-05 0.000899111247486695 1.73214774281806 0.588235294117647 4.2 4 2 abnormal adipose tissue morphology 0.00345689381991448 0.0384209621316537 1.73214774281806 0.588235294117647 4.2 4 2 abnormal embryonic-extraembryonic boundary morphology 0.00345689381991448 0.0384209621316537 1.73214774281806 0.588235294117647 4.2 4 2 increased regulatory T cell number 0.00345689381991448 0.0384209621316537 1.73214774281806 0.588235294117647 4.2 4 2 increased hepatoma incidence 0.00345689381991448 0.0384209621316537 1.73214774281806 0.588235294117647 4.2 4 2 failure to gastrulate 1.64705979390412e-06 6.11501677214404e-05 1.72838220424671 0.58695652173913 4.2 4 2 increased mortality induced by gamma-irradiation 0.000145685504625649 0.00297043190783854 1.72617481956696 0.586206896551724 4.2 4 2 increased double-positive T cell number 0.000145685504625649 0.00297043190783854 1.72617481956696 0.586206896551724 4.2 4 2 abnormal lysosome morphology 2.69686799407983e-05 0.000725238825434981 1.71771317829457 0.583333333333333 4.2 4 2 hemolytic anemia 0.000606831816481419 0.00940494793456404 1.71771317829457 0.583333333333333 4.2 4 2 increased hemangiosarcoma incidence 0.000606831816481419 0.00940494793456404 1.71771317829457 0.583333333333333 4.2 4 2 abnormal thymus involution 0.0153980471025702 0.123400283791971 1.71771317829457 0.583333333333333 4.2 4 2 increased growth rate 0.0153980471025702 0.123400283791971 1.71771317829457 0.583333333333333 4.2 4 2 small intestinal inflammation 0.0153980471025702 0.123400283791971 1.71771317829457 0.583333333333333 4.2 4 2 pale placenta 0.0153980471025702 0.123400283791971 1.71771317829457 0.583333333333333 4.2 4 2 persistent right dorsal aorta 0.0153980471025702 0.123400283791971 1.71771317829457 0.583333333333333 4.2 4 2 abnormal double-strand DNA break repair 5.06857231357137e-06 0.000164382816307899 1.71200648999459 0.581395348837209 4.2 4 2 abnormal T cell activation 2.26892161437382e-09 1.44716474762945e-07 1.71108108108108 0.581081081081081 4.2 4 2 abnormal immune system physiology 1.07769451775739e-14 1.41092900680079e-12 1.70979744936234 0.580645161290323 4.2 4 2 increased tumor incidence 1.07769451775739e-14 1.41092900680079e-12 1.70979744936234 0.580645161290323 4.2 4 2 autoimmune response 0.000110336785172254 0.00240756800978931 1.70979744936234 0.580645161290323 4.2 4 2 pale kidney 0.000110336785172254 0.00240756800978931 1.70979744936234 0.580645161290323 4.2 4 2 increased bone marrow cell number 2.04919500337058e-05 0.000561395354537795 1.70479804161567 0.578947368421053 4.2 4 2 heart inflammation 0.000456266178787283 0.00758099804443154 1.69883720930233 0.576923076923077 4.2 4 2 increased leukemia incidence 0.000456266178787283 0.00758099804443154 1.69883720930233 0.576923076923077 4.2 4 2 pulmonary edema 0.000456266178787283 0.00758099804443154 1.69883720930233 0.576923076923077 4.2 4 2 increased thymocyte apoptosis 0.000456266178787283 0.00758099804443154 1.69883720930233 0.576923076923077 4.2 4 2 abnormal spleen morphology 2.18271222613917e-19 5.17094920240114e-17 1.69232825447741 0.574712643678161 4.2 4 2 abnormal cell nucleus morphology 2.93513518480877e-06 0.000101404844058497 1.69160811479466 0.574468085106383 4.2 4 2 abnormal apoptosis 5.59387571306806e-07 2.35843488750115e-05 1.69044788975022 0.574074074074074 4.2 4 2 anemia 4.94197059769685e-23 1.53664398272137e-20 1.68863881847239 0.57345971563981 4.2 4 2 thrombocytopenia 3.33042621104873e-16 5.91745371427408e-14 1.6855589414595 0.572413793103448 4.2 4 2 increased T cell derived lymphoma incidence 2.22912157477061e-06 8.03614480759696e-05 1.68265780730897 0.571428571428571 4.2 4 2 failure of blastocyst to hatch from the zona pellucida 0.000342552302525075 0.00604325427327038 1.68265780730897 0.571428571428571 4.2 4 2 premature aging 0.000342552302525075 0.00604325427327038 1.68265780730897 0.571428571428571 4.2 4 2 increased incidence of induced tumors 0.00191522429218875 0.023761199136257 1.68265780730897 0.571428571428571 4.2 4 2 left pulmonary isomerism 0.00191522429218875 0.023761199136257 1.68265780730897 0.571428571428571 4.2 4 2 increased muscle cell glucose uptake 0.00191522429218875 0.023761199136257 1.68265780730897 0.571428571428571 4.2 4 2 increased lactate dehydrogenase level 0.0112423443005096 0.0967658527595767 1.68265780730897 0.571428571428571 4.2 4 2 amyloid beta deposits 0.0112423443005096 0.0967658527595767 1.68265780730897 0.571428571428571 4.2 4 2 abnormal sagittal suture morphology 0.0112423443005096 0.0967658527595767 1.68265780730897 0.571428571428571 4.2 4 2 lysosomal protein accumulation 0.0112423443005096 0.0967658527595767 1.68265780730897 0.571428571428571 4.2 4 2 abnormal inflammatory response 1.20387086886362e-08 7.04618537952531e-07 1.67681524547804 0.569444444444444 4.2 4 2 embryonic lethality before implantation, complete penetrance 7.63310162189082e-14 8.2553653410667e-12 1.67256186046512 0.568 4.2 4 2 abnormal chromosome morphology 4.74742473170581e-05 0.00113006880575294 1.67128849780013 0.567567567567568 4.2 4 2 skin inflammation 4.74742473170581e-05 0.00113006880575294 1.67128849780013 0.567567567567568 4.2 4 2 increased metastatic potential 0.000256905070029876 0.00480489745638585 1.66863565891473 0.566666666666667 4.2 4 2 arrested T cell differentiation 0.000256905070029876 0.00480489745638585 1.66863565891473 0.566666666666667 4.2 4 2 abnormal spleen marginal zone morphology 0.000256905070029876 0.00480489745638585 1.66863565891473 0.566666666666667 4.2 4 2 increased spleen weight 1.5116272851275e-12 1.47457759676653e-10 1.66776703025314 0.566371681415929 4.2 4 2 thymus atrophy 5.08843290681736e-06 0.000164382816307899 1.65636627906977 0.5625 4.2 4 2 decreased mast cell number 0.00822112842437001 0.075046080571084 1.65636627906977 0.5625 4.2 4 2 abnormal meiosis 0.00822112842437001 0.075046080571084 1.65636627906977 0.5625 4.2 4 2 sepsis 0.00822112842437001 0.075046080571084 1.65636627906977 0.5625 4.2 4 2 spleen hypoplasia 1.73753737824462e-11 1.46512685707915e-09 1.65461351052049 0.561904761904762 4.2 4 2 abnormal cell differentiation 2.69184056543597e-05 0.000725238825434981 1.65187748156551 0.560975609756098 4.2 4 2 abnormal preimplantation embryo development 0.00105840408204623 0.0149166014396033 1.64900465116279 0.56 4.2 4 2 decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 0.00105840408204623 0.0149166014396033 1.64900465116279 0.56 4.2 4 2 lung inflammation 3.36115274353285e-14 3.98136545216093e-12 1.64554035567715 0.558823529411765 4.2 4 2 liver hypoplasia 2.89739502130815e-06 0.00010080098063642 1.64220930232558 0.557692307692308 4.2 4 2 abnormal trophoblast giant cell morphology 0.000107958501298221 0.00237652010601172 1.6359173126615 0.555555555555556 4.2 4 2 decreased cellular sensitivity to gamma-irradiation 0.00602200637512769 0.0584005491545034 1.6359173126615 0.555555555555556 4.2 4 2 absent inner cell mass 0.00602200637512769 0.0584005491545034 1.6359173126615 0.555555555555556 4.2 4 2 abnormal neutrophil morphology 0.00602200637512769 0.0584005491545034 1.6359173126615 0.555555555555556 4.2 4 2 abnormal macrophage chemotaxis 0.00602200637512769 0.0584005491545034 1.6359173126615 0.555555555555556 4.2 4 2 abnormal hypoglossal nerve topology 0.00602200637512769 0.0584005491545034 1.6359173126615 0.555555555555556 4.2 4 2 crypts of Lieberkuhn abscesses 0.051686560071842 0.290072777029703 1.6359173126615 0.555555555555556 4.2 4 2 abnormal geniculate ganglion morphology 0.051686560071842 0.290072777029703 1.6359173126615 0.555555555555556 4.2 4 2 abnormal kindling response 0.051686560071842 0.290072777029703 1.6359173126615 0.555555555555556 4.2 4 2 multifocal hepatic necrosis 0.051686560071842 0.290072777029703 1.6359173126615 0.555555555555556 4.2 4 2 abnormal germ cell morphology 0.051686560071842 0.290072777029703 1.6359173126615 0.555555555555556 4.2 4 2 abnormal thymus lobule morphology 0.051686560071842 0.290072777029703 1.6359173126615 0.555555555555556 4.2 4 2 abnormal posterior semicircular canal morphology 0.051686560071842 0.290072777029703 1.6359173126615 0.555555555555556 4.2 4 2 abnormal thymus physiology 0.051686560071842 0.290072777029703 1.6359173126615 0.555555555555556 4.2 4 2 increased neuronal precursor cell number 0.051686560071842 0.290072777029703 1.6359173126615 0.555555555555556 4.2 4 2 liver hyperplasia 0.051686560071842 0.290072777029703 1.6359173126615 0.555555555555556 4.2 4 2 abnormal inguinal fat pad morphology 0.051686560071842 0.290072777029703 1.6359173126615 0.555555555555556 4.2 4 2 decreased susceptibility to atherosclerosis 0.051686560071842 0.290072777029703 1.6359173126615 0.555555555555556 4.2 4 2 abnormal liver vasculature morphology 0.051686560071842 0.290072777029703 1.6359173126615 0.555555555555556 4.2 4 2 eye opacity 0.051686560071842 0.290072777029703 1.6359173126615 0.555555555555556 4.2 4 2 abnormal telomere morphology 0.051686560071842 0.290072777029703 1.6359173126615 0.555555555555556 4.2 4 2 decreased susceptibility to parasitic infection induced morbidity/mortality 0.051686560071842 0.290072777029703 1.6359173126615 0.555555555555556 4.2 4 2 abnormal ductus venosus valve topology 0.051686560071842 0.290072777029703 1.6359173126615 0.555555555555556 4.2 4 2 symmetric azygos veins 0.051686560071842 0.290072777029703 1.6359173126615 0.555555555555556 4.2 4 2 increased endoplasmic reticulum stress 0.051686560071842 0.290072777029703 1.6359173126615 0.555555555555556 4.2 4 2 decreased leukocyte cell number 5.67751362375821e-14 6.41946142686298e-12 1.63352911220506 0.554744525547445 4.2 4 2 decreased T cell number 5.57842473178265e-16 9.24563554162642e-14 1.62778853098368 0.552795031055901 4.2 4 2 abnormal cell morphology 9.75732607700097e-12 8.6683387916214e-10 1.62730722154223 0.552631578947368 4.2 4 2 abnormal spermiogenesis 1.2403125830393e-06 4.67466295501553e-05 1.62463512429832 0.551724137931034 4.2 4 2 abnormal embryonic neuroepithelium morphology 1.2403125830393e-06 4.67466295501553e-05 1.62463512429832 0.551724137931034 4.2 4 2 increased susceptibility to induced arthritis 0.000584849899939756 0.00912109169968742 1.62463512429832 0.551724137931034 4.2 4 2 abnormal embryonic erythropoiesis 0.000584849899939756 0.00912109169968742 1.62463512429832 0.551724137931034 4.2 4 2 polychromatophilia 0.000584849899939756 0.00912109169968742 1.62463512429832 0.551724137931034 4.2 4 2 increased leukocyte cell number 1.87989918932117e-14 2.33812461671821e-12 1.62463512429832 0.551724137931034 4.2 4 2 increased skin tumor incidence 0.00441846302636375 0.0455110839672043 1.61955813953488 0.55 4.2 4 2 abnormal trophoblast layer morphology 6.45792847237732e-06 0.000200801213437982 1.61667122663019 0.549019607843137 4.2 4 2 increased B cell number 1.22849720418324e-11 1.07224098084414e-09 1.61074935400517 0.547008547008547 4.2 4 2 vasculitis 0.0366095758885668 0.232608735690447 1.6061733615222 0.545454545454545 4.2 4 2 loss of cortex neurons 0.0366095758885668 0.232608735690447 1.6061733615222 0.545454545454545 4.2 4 2 rectal hemorrhage 0.0366095758885668 0.232608735690447 1.6061733615222 0.545454545454545 4.2 4 2 abnormal spinal cord ventral horn morphology 0.0366095758885668 0.232608735690447 1.6061733615222 0.545454545454545 4.2 4 2 decreased palatine bone horizontal plate size 0.0366095758885668 0.232608735690447 1.6061733615222 0.545454545454545 4.2 4 2 increased number of Howell-Jolly bodies 0.0366095758885668 0.232608735690447 1.6061733615222 0.545454545454545 4.2 4 2 abnormal dendritic cell chemotaxis 0.0366095758885668 0.232608735690447 1.6061733615222 0.545454545454545 4.2 4 2 reduced sympathetic cervical ganglion size 0.0366095758885668 0.232608735690447 1.6061733615222 0.545454545454545 4.2 4 2 increased neutrophil cell number 6.82437452549644e-14 7.5447251698544e-12 1.60432718524459 0.544827586206897 4.2 4 2 pallor 2.88176635461565e-16 5.30992133859736e-14 1.59852491694352 0.542857142857143 4.2 4 2 abnormal lymph node morphology 1.89531551563202e-05 0.000529730038779175 1.59501937984496 0.541666666666667 4.2 4 2 decreased metastatic potential 0.00238956150119633 0.0283049249248851 1.59501937984496 0.541666666666667 4.2 4 2 abnormal inner cell mass apoptosis 0.00238956150119633 0.0283049249248851 1.59501937984496 0.541666666666667 4.2 4 2 decreased erythrocyte cell number 1.27129013940221e-14 1.62170985731436e-12 1.59423789068286 0.54140127388535 4.2 4 2 abnormal branching of the mammary ductal tree 0.000179116447158413 0.00352215148068422 1.59170333123822 0.540540540540541 4.2 4 2 abnormal placenta vasculature 1.06118841652913e-05 0.000316132477379187 1.58558139534884 0.538461538461538 4.2 4 2 abnormal leukocyte cell number 0.00176089830251499 0.0223481353444186 1.58558139534884 0.538461538461538 4.2 4 2 abnormal mast cell morphology 0.0261489245728966 0.181691200768381 1.58558139534884 0.538461538461538 4.2 4 2 increased foot pad pigmentation 0.0261489245728966 0.181691200768381 1.58558139534884 0.538461538461538 4.2 4 2 abnormal tail bud morphology 0.0261489245728966 0.181691200768381 1.58558139534884 0.538461538461538 4.2 4 2 increased circulating ammonia level 0.0261489245728966 0.181691200768381 1.58558139534884 0.538461538461538 4.2 4 2 small pituitary gland 0.0261489245728966 0.181691200768381 1.58558139534884 0.538461538461538 4.2 4 2 absent hypoglossal nerve 0.0261489245728966 0.181691200768381 1.58558139534884 0.538461538461538 4.2 4 2 abnormal leukocyte adhesion 0.00013335629159318 0.00276436479448363 1.58558139534884 0.538461538461538 4.2 4 2 increased hepatocyte apoptosis 0.00013335629159318 0.00276436479448363 1.58558139534884 0.538461538461538 4.2 4 2 embryonic growth arrest 4.17383849963157e-20 1.03824232678335e-17 1.58162486036356 0.537117903930131 4.2 4 2 thymus hypoplasia 1.20598293135598e-12 1.1999530166992e-10 1.57901584091675 0.536231884057971 4.2 4 2 increased bone resorption 0.00129921151766404 0.0180043935943694 1.57749169435216 0.535714285714286 4.2 4 2 embryonic lethality between implantation and somite formation, complete penetrance 4.36634441890504e-21 1.20680908244737e-18 1.57448694826768 0.53469387755102 4.2 4 2 dermatitis 4.4482370571193e-06 0.00014655615469648 1.57386527666399 0.53448275862069 4.2 4 2 salivary gland inflammation 0.000959643991265335 0.0137983492963729 1.57048062015504 0.533333333333333 4.2 4 2 abnormal microglial cell physiology 0.000959643991265335 0.0137983492963729 1.57048062015504 0.533333333333333 4.2 4 2 abnormal trophectoderm morphology 0.0187971802946483 0.136719257260052 1.57048062015504 0.533333333333333 4.2 4 2 decreased thymocyte apoptosis 0.0187971802946483 0.136719257260052 1.57048062015504 0.533333333333333 4.2 4 2 liver vascular congestion 0.0187971802946483 0.136719257260052 1.57048062015504 0.533333333333333 4.2 4 2 abnormal embryonic hematopoiesis 0.00070955225630933 0.0107951757649508 1.56434593023256 0.53125 4.2 4 2 abnormal spongiotrophoblast layer morphology 0.00070955225630933 0.0107951757649508 1.56434593023256 0.53125 4.2 4 2 pale yolk sac 6.54666123484793e-08 3.28986259023924e-06 1.5610198935276 0.530120481927711 4.2 4 2 embryonic lethality, complete penetrance 3.55136032327019e-26 1.60618341893356e-23 1.56001895458191 0.529780564263323 4.2 4 2 decreased cytotoxic T cell cytolysis 0.00052512877847427 0.00850982303879314 1.55893296853625 0.529411764705882 4.2 4 2 abnormal circulating chemokine level 0.0135808923543825 0.112640598444521 1.55893296853625 0.529411764705882 4.2 4 2 decreased embryo size 1.98264023208462e-38 1.9727270309242e-35 1.55857059453148 0.52928870292887 4.2 4 2 increased susceptibility to bacterial infection induced morbidity/mortality 5.86840497426558e-07 2.43378302259229e-05 1.55412144702842 0.527777777777778 4.2 4 2 decreased susceptibility to induced arthritis 9.50935005765215e-06 0.000288469613029387 1.54981640146879 0.526315789473684 4.2 4 2 increased macrophage cell number 9.50935005765215e-06 0.000288469613029387 1.54981640146879 0.526315789473684 4.2 4 2 small superior vagus ganglion 0.0098525018300783 0.0875289225082849 1.54981640146879 0.526315789473684 4.2 4 2 abnormal stationary movement 0.0098525018300783 0.0875289225082849 1.54981640146879 0.526315789473684 4.2 4 2 increased malignant tumor incidence 0.0098525018300783 0.0875289225082849 1.54981640146879 0.526315789473684 4.2 4 2 shortened RR interval 0.0098525018300783 0.0875289225082849 1.54981640146879 0.526315789473684 4.2 4 2 decreased circulating serum albumin level 6.58881748085145e-09 3.94932132135373e-07 1.5466854592436 0.525252525252525 4.2 4 2 abnormal eye pigmentation 0.00717202563395626 0.0678342728686927 1.54243632336656 0.523809523809524 4.2 4 2 liver degeneration 0.00717202563395626 0.0678342728686927 1.54243632336656 0.523809523809524 4.2 4 2 increased acute inflammation 0.00717202563395626 0.0678342728686927 1.54243632336656 0.523809523809524 4.2 4 2 increased bone mineral content 1.56990432291134e-09 1.04136986753119e-07 1.53986345210156 0.522935779816514 4.2 4 2 muscular atrophy 0.000117960172246935 0.00251867749754722 1.53924947145877 0.522727272727273 4.2 4 2 abnormal Wolffian duct morphology 0.00523578624608963 0.0517853609826957 1.53633973710819 0.521739130434783 4.2 4 2 lethality throughout fetal growth and development, complete penetrance 2.49287375331661e-15 3.54344197792861e-13 1.5343182374541 0.521052631578947 4.2 4 2 seminiferous tubule degeneration 9.25286536276495e-07 3.59632852966841e-05 1.53283211213762 0.520547945205479 4.2 4 2 mandible hypoplasia 0.00383164870527561 0.0415584704666218 1.53121860465116 0.52 4.2 4 2 embryonic lethality during organogenesis, complete penetrance 5.24021890048793e-42 8.69002967664249e-39 1.53016694352159 0.519642857142857 4.2 4 2 preweaning lethality, complete penetrance 5.67214659130175e-55 2.82189292917262e-51 1.52803519798869 0.518918918918919 4.2 4 2 decreased circulating fructosamine level 0.00281001823339619 0.0329713224319482 1.52685615848407 0.518518518518518 4.2 4 2 thrombocytosis 1.49319711296517e-05 0.000429402059942295 1.52309542902967 0.517241379310345 4.2 4 2 blood in lymph vessels 0.00206459896522578 0.0254872949181098 1.52309542902967 0.517241379310345 4.2 4 2 small spleen 6.81858394027196e-08 3.35865892107455e-06 1.52086378737542 0.516483516483517 4.2 4 2 decreased thymus weight 0.00151939134781519 0.0197362192046489 1.51981995498875 0.516129032258065 4.2 4 2 decreased double-negative T cell number 0.00151939134781519 0.0197362192046489 1.51981995498875 0.516129032258065 4.2 4 2 increased inflammatory response 3.82497547018247e-08 2.04615623270514e-06 1.51882007343941 0.515789473684211 4.2 4 2 abnormal skeleton physiology 0.00111977642493239 0.0156926414479961 1.5169415081043 0.515151515151515 4.2 4 2 pericardial edema 3.45122603764602e-06 0.000117601709159513 1.5156292749658 0.514705882352941 4.2 4 2 abnormal vitelline vasculature morphology 2.13686486746511e-09 1.38063671631674e-07 1.51073407482305 0.51304347826087 4.2 4 2 small liver 8.03131480374753e-07 3.17109453560666e-05 1.51007751937985 0.512820512820513 4.2 4 2 impaired macrophage chemotaxis 0.000451503391165 0.00758099804443154 1.51007751937985 0.512820512820513 4.2 4 2 small placenta 0.000183628075088909 0.00359665225813906 1.50504392764858 0.511111111111111 4.2 4 2 decreased bone trabecula number 0.000136260136126231 0.00281283890965975 1.50365165759525 0.51063829787234 4.2 4 2 decreased circulating total protein level 4.15702304527628e-05 0.00101877781528323 1.49909513742072 0.509090909090909 4.2 4 2 abnormal placenta morphology 1.22950508018774e-06 4.67466295501553e-05 1.49096261407124 0.506329113924051 4.2 4 2 oxidative stress 4.33191567106285e-07 1.84198978320835e-05 1.47232558139535 0.5 4.2 4 2 increased susceptibility to parasitic infection 4.33191567106285e-07 1.84198978320835e-05 1.47232558139535 0.5 4.2 4 2 hydrops fetalis 5.98552561086226e-06 0.000189668725567132 1.47232558139535 0.5 4.2 4 2 abnormal vascular development 1.44355253455839e-05 0.000419980927451928 1.47232558139535 0.5 4.2 4 2 decreased caudal vertebrae number 1.93726059287786e-05 0.000535437302753741 1.47232558139535 0.5 4.2 4 2 failure of primitive streak formation 0.00232923043932104 0.0281260229019956 1.47232558139535 0.5 4.2 4 2 decreased susceptibility to parasitic infection 0.00232923043932104 0.0281260229019956 1.47232558139535 0.5 4.2 4 2 abnormal mitotic spindle morphology 0.00432082494912833 0.0447835502539864 1.47232558139535 0.5 4.2 4 2 abnormal erythrocyte osmotic lysis 0.00590239910803623 0.0578040070127564 1.47232558139535 0.5 4.2 4 2 abnormal limb posture 0.0110970667561431 0.0961810228428782 1.47232558139535 0.5 4.2 4 2 increased adenoma incidence 0.0110970667561431 0.0961810228428782 1.47232558139535 0.5 4.2 4 2 embryonic lethality before implantation, incomplete penetrance 0.0110970667561431 0.0961810228428782 1.47232558139535 0.5 4.2 4 2 abnormal vascular regression 0.0152865406337929 0.123400283791971 1.47232558139535 0.5 4.2 4 2 decreased myocardial infarction size 0.0152865406337929 0.123400283791971 1.47232558139535 0.5 4.2 4 2 abnormal physiological neovascularization 0.0152865406337929 0.123400283791971 1.47232558139535 0.5 4.2 4 2 abnormal bile duct morphology 0.0211397783336372 0.151542359091996 1.47232558139535 0.5 4.2 4 2 primary atelectasis 0.0211397783336372 0.151542359091996 1.47232558139535 0.5 4.2 4 2 impaired leukocyte tethering or rolling 0.0211397783336372 0.151542359091996 1.47232558139535 0.5 4.2 4 2 abnormal mouth morphology 0.0293732321649266 0.195624939786493 1.47232558139535 0.5 4.2 4 2 poor circulation 0.0293732321649266 0.195624939786493 1.47232558139535 0.5 4.2 4 2 disorganized yolk sac vascular plexus 0.0293732321649266 0.195624939786493 1.47232558139535 0.5 4.2 4 2 increased cochlear outer hair cell number 0.0293732321649266 0.195624939786493 1.47232558139535 0.5 4.2 4 2 abnormal Langerhans cell physiology 0.0293732321649266 0.195624939786493 1.47232558139535 0.5 4.2 4 2 decreased creatinine clearance 0.0293732321649266 0.195624939786493 1.47232558139535 0.5 4.2 4 2 decreased fibroblast apoptosis 0.0293732321649266 0.195624939786493 1.47232558139535 0.5 4.2 4 2 absent visceral yolk sac blood islands 0.0410555048452835 0.248783357619105 1.47232558139535 0.5 4.2 4 2 abnormal adrenal gland secretion 0.0410555048452835 0.248783357619105 1.47232558139535 0.5 4.2 4 2 abnormal antigen presentation 0.0410555048452835 0.248783357619105 1.47232558139535 0.5 4.2 4 2 absent olfactory bulb 0.0410555048452835 0.248783357619105 1.47232558139535 0.5 4.2 4 2 abnormal viscerocranium morphology 0.0410555048452835 0.248783357619105 1.47232558139535 0.5 4.2 4 2 decreased compact bone area 0.0410555048452835 0.248783357619105 1.47232558139535 0.5 4.2 4 2 testis degeneration 0.0410555048452835 0.248783357619105 1.47232558139535 0.5 4.2 4 2 multiple persisting craniopharyngeal ducts 0.0410555048452835 0.248783357619105 1.47232558139535 0.5 4.2 4 2 abnormal vitelline vein topology 0.0410555048452835 0.248783357619105 1.47232558139535 0.5 4.2 4 2 abnormal mating frequency 0.0578211046745632 0.310647943580942 1.47232558139535 0.5 4.2 4 2 small thyroid gland 0.0578211046745632 0.310647943580942 1.47232558139535 0.5 4.2 4 2 abnormal gastrocnemius morphology 0.0578211046745632 0.310647943580942 1.47232558139535 0.5 4.2 4 2 loss of dopaminergic neurons 0.0578211046745632 0.310647943580942 1.47232558139535 0.5 4.2 4 2 dilated bile duct 0.0578211046745632 0.310647943580942 1.47232558139535 0.5 4.2 4 2 abnormal thymus corticomedullary boundary morphology 0.0578211046745632 0.310647943580942 1.47232558139535 0.5 4.2 4 2 decreased red blood cell distribution width 0.0578211046745632 0.310647943580942 1.47232558139535 0.5 4.2 4 2 decreased mammary gland epithelial cell proliferation 0.0578211046745632 0.310647943580942 1.47232558139535 0.5 4.2 4 2 increased fibrosarcoma incidence 0.0578211046745632 0.310647943580942 1.47232558139535 0.5 4.2 4 2 prenatal growth retardation 0.0578211046745632 0.310647943580942 1.47232558139535 0.5 4.2 4 2 embryonic lethality between implantation and placentation, incomplete penetrance 0.0578211046745632 0.310647943580942 1.47232558139535 0.5 4.2 4 2 absent trophoblast giant cells 0.0822606357470153 0.380340764722492 1.47232558139535 0.5 4.2 4 2 acrania 0.0822606357470153 0.380340764722492 1.47232558139535 0.5 4.2 4 2 peritoneal inflammation 0.0822606357470153 0.380340764722492 1.47232558139535 0.5 4.2 4 2 lymphedema 0.0822606357470153 0.380340764722492 1.47232558139535 0.5 4.2 4 2 abnormal submandibular gland morphology 0.0822606357470153 0.380340764722492 1.47232558139535 0.5 4.2 4 2 abnormal plasma membrane morphology 0.0822606357470153 0.380340764722492 1.47232558139535 0.5 4.2 4 2 ascites 0.0822606357470153 0.380340764722492 1.47232558139535 0.5 4.2 4 2 abnormal developmental vascular remodeling 0.0822606357470153 0.380340764722492 1.47232558139535 0.5 4.2 4 2 increased platelet aggregation 0.0822606357470153 0.380340764722492 1.47232558139535 0.5 4.2 4 2 aorta stenosis 0.0822606357470153 0.380340764722492 1.47232558139535 0.5 4.2 4 2 abnormal left subclavian artery morphology 0.0822606357470153 0.380340764722492 1.47232558139535 0.5 4.2 4 2 abnormal inferior vena cava valve morphology 0.0822606357470153 0.380340764722492 1.47232558139535 0.5 4.2 4 2 thin ventricle myocardium compact layer 0.0822606357470153 0.380340764722492 1.47232558139535 0.5 4.2 4 2 thick aortic valve cusps 0.0822606357470153 0.380340764722492 1.47232558139535 0.5 4.2 4 2 decreased circulating lactate level 0.0822606357470153 0.380340764722492 1.47232558139535 0.5 4.2 4 2 liver inflammation 5.6210101238115e-09 3.45241053900768e-07 1.47232558139535 0.5 4.2 4 2 embryonic lethality between somite formation and embryo turning, complete penetrance 8.02415440605182e-06 0.000247951355093837 1.47232558139535 0.5 4.2 4 2 intracranial hemorrhage 3.49326099771442e-05 0.000895823374413879 1.47232558139535 0.5 4.2 4 2 decreased hair follicle number 0.00093263268125819 0.0135272524468207 1.47232558139535 0.5 4.2 4 2 decreased neuron apoptosis 0.00093263268125819 0.0135272524468207 1.47232558139535 0.5 4.2 4 2 abnormal fat pad morphology 0.00316955393918622 0.0356593368330153 1.47232558139535 0.5 4.2 4 2 abnormal cellular respiration 0.00316955393918622 0.0356593368330153 1.47232558139535 0.5 4.2 4 2 abnormal placenta labyrinth morphology 3.71662008202876e-06 0.00012493368181144 1.45368854871946 0.493670886075949 4.2 4 2 microcephaly 1.60647444393731e-05 0.000451537308394809 1.45098752949107 0.492753623188406 4.2 4 2 increased lymphocyte cell number 1.60647444393731e-05 0.000451537308394809 1.45098752949107 0.492753623188406 4.2 4 2 decreased cell proliferation 2.46676535521778e-12 2.27262178559416e-10 1.44845003142678 0.491891891891892 4.2 4 2 increased sarcoma incidence 0.000309217144388756 0.00559401924848749 1.44227812055055 0.489795918367347 4.2 4 2 trabecula carnea hypoplasia 0.000562599647953989 0.00888550237641618 1.43960723514212 0.488888888888889 4.2 4 2 abnormal myocardial trabeculae morphology 0.000562599647953989 0.00888550237641618 1.43960723514212 0.488888888888889 4.2 4 2 abnormal cell migration 0.000562599647953989 0.00888550237641618 1.43960723514212 0.488888888888889 4.2 4 2 decreased trabecular bone volume 0.00138970550684672 0.0189939145509958 1.43457364341085 0.487179487179487 4.2 4 2 abnormal hepatocyte morphology 1.03485974576055e-07 4.85700682562145e-06 1.43253299811439 0.486486486486487 4.2 4 2 abnormal angiogenesis 1.31723941025986e-05 0.000387767222842769 1.43253299811439 0.486486486486487 4.2 4 2 abnormal respiratory electron transport chain 0.00188250142537949 0.0235312678172436 1.43253299811439 0.486486486486487 4.2 4 2 decreased hematocrit 1.13069766583424e-09 7.72945762245012e-08 1.43198789423383 0.486301369863014 4.2 4 2 ovary cysts 0.00255317924601284 0.030028526593177 1.43025913621262 0.485714285714286 4.2 4 2 increased carcinoma incidence 0.00255317924601284 0.030028526593177 1.43025913621262 0.485714285714286 4.2 4 2 decreased glycogen level 0.00255317924601284 0.030028526593177 1.43025913621262 0.485714285714286 4.2 4 2 abnormal ovarian folliculogenesis 0.00346754009992212 0.0384209621316537 1.4277096546864 0.484848484848485 4.2 4 2 increased cardiomyocyte apoptosis 0.00346754009992212 0.0384209621316537 1.4277096546864 0.484848484848485 4.2 4 2 increased sacral vertebrae number 5.70891665201907e-05 0.00134605973193341 1.42631540697674 0.484375 4.2 4 2 pericardial effusion 7.66301615942506e-05 0.00174878465106145 1.42483120780195 0.483870967741935 4.2 4 2 anophthalmia 2.5004386060225e-06 8.94941155752656e-05 1.42269662921348 0.48314606741573 4.2 4 2 decreased hemoglobin content 3.89459878286465e-09 2.45261125882932e-07 1.42011545439551 0.482269503546099 4.2 4 2 abnormal coat/hair pigmentation 1.50694956045824e-07 6.8780495993392e-06 1.41974252491694 0.482142857142857 4.2 4 2 abnormal neural tube closure 5.97925560172434e-06 0.000189668725567132 1.419108994116 0.481927710843373 4.2 4 2 rectal prolapse 0.00877389563448767 0.0796535233240441 1.41779500430663 0.481481481481481 4.2 4 2 abnormal trigeminal ganglion morphology 0.00877389563448767 0.0796535233240441 1.41779500430663 0.481481481481481 4.2 4 2 abnormal feces composition 0.0120054223316359 0.102977544999808 1.41343255813953 0.48 4.2 4 2 increased cellular sensitivity to ionizing radiation 0.0120054223316359 0.102977544999808 1.41343255813953 0.48 4.2 4 2 abnormal ovary morphology 3.43902515238943e-05 0.00089576702267735 1.41011464133639 0.47887323943662 4.2 4 2 decreased spleen weight 4.60742186805032e-05 0.00110733931369808 1.40831142568251 0.478260869565217 4.2 4 2 pancreas inflammation 0.0164699072236922 0.123400283791971 1.40831142568251 0.478260869565217 4.2 4 2 dilated heart 0.0164699072236922 0.123400283791971 1.40831142568251 0.478260869565217 4.2 4 2 internal hemorrhage 6.17461698203338e-05 0.00144219340308057 1.40640055536272 0.477611940298507 4.2 4 2 abnormal embryonic tissue morphology 4.55995634516295e-09 2.83572285214821e-07 1.40221483942414 0.476190476190476 4.2 4 2 abnormal hematopoietic system physiology 0.0226633724518261 0.161302257436102 1.40221483942414 0.476190476190476 4.2 4 2 abnormal tumor vascularization 0.0226633724518261 0.161302257436102 1.40221483942414 0.476190476190476 4.2 4 2 absent segment of posterior cerebral artery 0.0226633724518261 0.161302257436102 1.40221483942414 0.476190476190476 4.2 4 2 prenatal lethality, complete penetrance 1.18403004988412e-15 1.78501499944651e-13 1.39817968880709 0.474820143884892 4.2 4 2 increased hepatocellular carcinoma incidence 0.000268291832573251 0.00492528364225802 1.39483476132191 0.473684210526316 4.2 4 2 enlarged adrenal glands 0.0312983271868403 0.205964520839326 1.39483476132191 0.473684210526316 4.2 4 2 increased susceptibility to ischemic brain injury 0.0312983271868403 0.205964520839326 1.39483476132191 0.473684210526316 4.2 4 2 oliguria 0.0312983271868403 0.205964520839326 1.39483476132191 0.473684210526316 4.2 4 2 abnormal blastocyst morphology 0.0312983271868403 0.205964520839326 1.39483476132191 0.473684210526316 4.2 4 2 Leydig cell hypoplasia 0.0312983271868403 0.205964520839326 1.39483476132191 0.473684210526316 4.2 4 2 increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 0.0312983271868403 0.205964520839326 1.39483476132191 0.473684210526316 4.2 4 2 decreased circulating calcium level 0.000360349662826427 0.00631246328366716 1.39201691331924 0.472727272727273 4.2 4 2 abnormal placenta development 0.000484217752366433 0.00789830596073117 1.38898639754278 0.471698113207547 4.2 4 2 failure of chorioallantoic fusion 0.00065098540680292 0.0100579267044861 1.38571819425445 0.470588235294118 4.2 4 2 abnormal oocyte morphology 0.00502586545861692 0.0499075462207968 1.38571819425445 0.470588235294118 4.2 4 2 abnormal direction of heart looping 0.00502586545861692 0.0499075462207968 1.38571819425445 0.470588235294118 4.2 4 2 abnormal interatrial septum morphology 0.0434108675520771 0.259266585920268 1.38571819425445 0.470588235294118 4.2 4 2 abnormal dorsal-ventral axis patterning 0.0434108675520771 0.259266585920268 1.38571819425445 0.470588235294118 4.2 4 2 abnormal involuntary movement 0.0434108675520771 0.259266585920268 1.38571819425445 0.470588235294118 4.2 4 2 abnormal melanosome morphology 0.0434108675520771 0.259266585920268 1.38571819425445 0.470588235294118 4.2 4 2 enhanced behavioral response to cocaine 0.0434108675520771 0.259266585920268 1.38571819425445 0.470588235294118 4.2 4 2 delayed heart development 0.0434108675520771 0.259266585920268 1.38571819425445 0.470588235294118 4.2 4 2 abnormal cell cytoskeleton morphology 0.0434108675520771 0.259266585920268 1.38571819425445 0.470588235294118 4.2 4 2 decreased neutrophil cell number 3.33129675357951e-07 1.4666549866423e-05 1.38423772609819 0.47008547008547 4.2 4 2 abnormal respiratory system physiology 0.000875651252528353 0.0129268990543874 1.38218319886094 0.469387755102041 4.2 4 2 decreased circulating creatinine level 0.000875651252528353 0.0129268990543874 1.38218319886094 0.469387755102041 4.2 4 2 abnormal somite development 2.93660346349052e-05 0.000772994827029911 1.3791404180159 0.468354430379747 4.2 4 2 neuron degeneration 0.00117852131504418 0.0164695043324292 1.37834735279565 0.468085106382979 4.2 4 2 increased erythrocyte cell number 0.000284656322208015 0.00518741832595192 1.37417054263566 0.466666666666667 4.2 4 2 abnormal brain vasculature morphology 0.00927658255465719 0.0839109058353082 1.37417054263566 0.466666666666667 4.2 4 2 decreased hepatocyte number 0.0605315388270895 0.315593996440641 1.37417054263566 0.466666666666667 4.2 4 2 abnormal prostate gland morphology 0.0605315388270895 0.315593996440641 1.37417054263566 0.466666666666667 4.2 4 2 absent egg cylinders 0.0605315388270895 0.315593996440641 1.37417054263566 0.466666666666667 4.2 4 2 increased airway responsiveness 0.0605315388270895 0.315593996440641 1.37417054263566 0.466666666666667 4.2 4 2 joint inflammation 0.0605315388270895 0.315593996440641 1.37417054263566 0.466666666666667 4.2 4 2 delayed intramembranous bone ossification 0.0605315388270895 0.315593996440641 1.37417054263566 0.466666666666667 4.2 4 2 abnormal energy homeostasis 0.0605315388270895 0.315593996440641 1.37417054263566 0.466666666666667 4.2 4 2 bicuspid aortic valve 0.0605315388270895 0.315593996440641 1.37417054263566 0.466666666666667 4.2 4 2 astrocytosis 7.00217553719622e-05 0.00160533747914982 1.37148136349156 0.465753424657534 4.2 4 2 abnormal homeostasis 0.0021387793684948 0.0263376914808456 1.36960519199567 0.465116279069767 4.2 4 2 small superior cervical ganglion 0.0126332235617991 0.107436388410172 1.36715946843854 0.464285714285714 4.2 4 2 Leydig cell hyperplasia 0.00288424427826812 0.0336833692121687 1.36459444129325 0.463414634146341 4.2 4 2 axon degeneration 0.000686238833336422 0.0105371549254589 1.36326442721792 0.462962962962963 4.2 4 2 decreased platelet aggregation 0.000686238833336422 0.0105371549254589 1.36326442721792 0.462962962962963 4.2 4 2 decreased bone resorption 0.0172365850947213 0.128563734402157 1.35906976744186 0.461538461538462 4.2 4 2 absent teeth 0.0849686876188489 0.383941163400339 1.35906976744186 0.461538461538462 4.2 4 2 absent common myeloid progenitor cells 0.0849686876188489 0.383941163400339 1.35906976744186 0.461538461538462 4.2 4 2 abnormal grip strength 0.0849686876188489 0.383941163400339 1.35906976744186 0.461538461538462 4.2 4 2 abnormal digestion 0.0849686876188489 0.383941163400339 1.35906976744186 0.461538461538462 4.2 4 2 abnormal telomere length 0.0849686876188489 0.383941163400339 1.35906976744186 0.461538461538462 4.2 4 2 small otic vesicle 0.0849686876188489 0.383941163400339 1.35906976744186 0.461538461538462 4.2 4 2 abnormal exocrine pancreas morphology 0.0849686876188489 0.383941163400339 1.35906976744186 0.461538461538462 4.2 4 2 abnormal liver physiology 6.12727841238326e-06 0.000191718302525828 1.35453953488372 0.46 4.2 4 2 kidney inflammation 0.00123599778969654 0.017176226267431 1.35453953488372 0.46 4.2 4 2 increased circulating phosphate level 0.00525770612290187 0.0518989840504698 1.35294783155248 0.459459459459459 4.2 4 2 vertebral transformation 0.00165976902784693 0.0213921008122759 1.34963178294574 0.458333333333333 4.2 4 2 decreased body height 0.0235673578821385 0.167019381002335 1.34963178294574 0.458333333333333 4.2 4 2 increased neuron apoptosis 5.76543428845629e-05 0.00135297337665425 1.34508756818834 0.45679012345679 4.2 4 2 abnormal allantois morphology 0.00222978689411055 0.0271227134430318 1.34429726996967 0.456521739130435 4.2 4 2 abnormal myelin sheath morphology 0.00222978689411055 0.0271227134430318 1.34429726996967 0.456521739130435 4.2 4 2 embryonic lethality between implantation and placentation, complete penetrance 0.00222978689411055 0.0271227134430318 1.34429726996967 0.456521739130435 4.2 4 2 decreased brain weight 0.000715694863884145 0.0108554327677549 1.34317421460628 0.456140350877193 4.2 4 2 hemorrhage 1.47897509024222e-11 1.26860363344053e-09 1.34075606135576 0.45531914893617 4.2 4 2 increased sensitivity to xenobiotic induced morbidity/mortality 3.78063883929116e-06 0.000125391188169823 1.3384778012685 0.454545454545455 4.2 4 2 abnormal platelet physiology 0.000957813142094754 0.0137983492963729 1.3384778012685 0.454545454545455 4.2 4 2 osteoporosis 0.00299692166078922 0.0345932372678107 1.3384778012685 0.454545454545455 4.2 4 2 decreased macrophage cell number 0.00299692166078922 0.0345932372678107 1.3384778012685 0.454545454545455 4.2 4 2 decreased blood urea nitrogen level 0.00299692166078922 0.0345932372678107 1.3384778012685 0.454545454545455 4.2 4 2 lethality, incomplete penetrance 0.00299692166078922 0.0345932372678107 1.3384778012685 0.454545454545455 4.2 4 2 increased myocardial infarction size 0.0323019605315619 0.210343263932618 1.3384778012685 0.454545454545455 4.2 4 2 abnormal retinal layer morphology 0.0323019605315619 0.210343263932618 1.3384778012685 0.454545454545455 4.2 4 2 abnormal occipital bone morphology 0.0323019605315619 0.210343263932618 1.3384778012685 0.454545454545455 4.2 4 2 abnormal sperm midpiece morphology 0.0323019605315619 0.210343263932618 1.3384778012685 0.454545454545455 4.2 4 2 decreased atrioventricular cushion size 0.120303185629055 0.479573997199159 1.3384778012685 0.454545454545455 4.2 4 2 abnormal sebaceous gland morphology 0.120303185629055 0.479573997199159 1.3384778012685 0.454545454545455 4.2 4 2 abnormal food preference 0.120303185629055 0.479573997199159 1.3384778012685 0.454545454545455 4.2 4 2 abnormal proximal-distal axis patterning 0.120303185629055 0.479573997199159 1.3384778012685 0.454545454545455 4.2 4 2 fatigue 0.120303185629055 0.479573997199159 1.3384778012685 0.454545454545455 4.2 4 2 abnormal radial glial cell morphology 0.120303185629055 0.479573997199159 1.3384778012685 0.454545454545455 4.2 4 2 abnormal coronal suture morphology 0.120303185629055 0.479573997199159 1.3384778012685 0.454545454545455 4.2 4 2 abnormal extraembryonic ectoderm morphology 0.120303185629055 0.479573997199159 1.3384778012685 0.454545454545455 4.2 4 2 abnormal phrenic nerve innervation pattern to diaphragm 0.120303185629055 0.479573997199159 1.3384778012685 0.454545454545455 4.2 4 2 chylous ascites 0.120303185629055 0.479573997199159 1.3384778012685 0.454545454545455 4.2 4 2 thin hypoglossal nerve 0.120303185629055 0.479573997199159 1.3384778012685 0.454545454545455 4.2 4 2 abnormal osteoclast physiology 0.00041524106612647 0.00722316190202514 1.33429505813953 0.453125 4.2 4 2 increased eosinophil cell number 0.000554169859560008 0.0088649358563056 1.32984246061515 0.451612903225806 4.2 4 2 increased lung adenoma incidence 0.0130318776490601 0.110449048218184 1.32984246061515 0.451612903225806 4.2 4 2 abnormal mitochondrial ATP synthesis coupled electron transport 0.0130318776490601 0.110449048218184 1.32984246061515 0.451612903225806 4.2 4 2 abnormal optic stalk morphology 0.0443988798211517 0.263440837861291 1.32509302325581 0.45 4.2 4 2 abnormal circulating cytokine level 0.0443988798211517 0.263440837861291 1.32509302325581 0.45 4.2 4 2 abnormal embryo development 6.080537699738e-07 2.47956352919644e-05 1.32076265389877 0.448529411764706 4.2 4 2 glomerulosclerosis 0.000987179907072023 0.0140722637182903 1.32001603849238 0.448275862068966 4.2 4 2 decreased granulocyte number 0.017676076063468 0.130866328879306 1.32001603849238 0.448275862068966 4.2 4 2 edema 2.43985050247941e-08 1.37934730111762e-06 1.31824499729584 0.447674418604651 4.2 4 2 incomplete somite formation 0.00729796745970302 0.0688944745958681 1.31734394124847 0.447368421052632 4.2 4 2 azoospermia 9.48182160006767e-08 4.53577523657083e-06 1.31490712300717 0.446540880503145 4.2 4 2 increased circulating alkaline phosphatase level 9.73977575456331e-08 4.61479851228119e-06 1.3087338501292 0.444444444444444 4.2 4 2 increased cell proliferation 0.00175879268567372 0.0223481353444186 1.3087338501292 0.444444444444444 4.2 4 2 neurodegeneration 0.00175879268567372 0.0223481353444186 1.3087338501292 0.444444444444444 4.2 4 2 decreased tumor growth/size 0.00175879268567372 0.0223481353444186 1.3087338501292 0.444444444444444 4.2 4 2 abnormal cell adhesion 0.00175879268567372 0.0223481353444186 1.3087338501292 0.444444444444444 4.2 4 2 abnormal pharyngeal arch morphology 0.00982908044068923 0.0875289225082849 1.3087338501292 0.444444444444444 4.2 4 2 abnormal eye muscle morphology 0.0240067366629082 0.169409240990026 1.3087338501292 0.444444444444444 4.2 4 2 abnormal iron level 0.0612277389268289 0.315593996440641 1.3087338501292 0.444444444444444 4.2 4 2 long tibia 0.0612277389268289 0.315593996440641 1.3087338501292 0.444444444444444 4.2 4 2 increased susceptibility to autoimmune disorder 0.0612277389268289 0.315593996440641 1.3087338501292 0.444444444444444 4.2 4 2 darkened coat color 0.0612277389268289 0.315593996440641 1.3087338501292 0.444444444444444 4.2 4 2 small thoracic cage 0.0612277389268289 0.315593996440641 1.3087338501292 0.444444444444444 4.2 4 2 decreased tumor latency 0.0612277389268289 0.315593996440641 1.3087338501292 0.444444444444444 4.2 4 2 abnormal nervous system morphology 0.00019126444463909 0.00372943712115502 1.30459228731233 0.443037974683544 4.2 4 2 abnormal embryo size 9.59584031228889e-06 0.000289329124567498 1.30294299238526 0.442477876106195 4.2 4 2 kinked neural tube 0.00234765392343494 0.0282798505304814 1.30244186046512 0.442307692307692 4.2 4 2 increased oxygen consumption 0.000111196495524819 0.00241573172592129 1.30112493239589 0.441860465116279 4.2 4 2 abnormal heart morphology 3.74573876897929e-10 2.66215005366742e-08 1.30023557837511 0.441558441558442 4.2 4 2 decreased circulating alanine transaminase level 0.00058160508812231 0.00912109169968742 1.29911080711354 0.441176470588235 4.2 4 2 enlarged liver sinusoidal spaces 0.0132457678092433 0.111821686549501 1.29911080711354 0.441176470588235 4.2 4 2 decreased regulatory T cell number 0.0132457678092433 0.111821686549501 1.29911080711354 0.441176470588235 4.2 4 2 decreased circulating alkaline phosphatase level 0.00313364425048155 0.0355122554581907 1.29564651162791 0.44 4.2 4 2 testicular atrophy 0.00313364425048155 0.0355122554581907 1.29564651162791 0.44 4.2 4 2 abnormal circulating protein level 0.00313364425048155 0.0355122554581907 1.29564651162791 0.44 4.2 4 2 abnormal keratinocyte physiology 0.0326517358146762 0.210964137244174 1.29564651162791 0.44 4.2 4 2 decreased acute inflammation 0.0326517358146762 0.210964137244174 1.29564651162791 0.44 4.2 4 2 embryonic lethality during organogenesis, incomplete penetrance 6.60276022479101e-10 4.62658198849792e-08 1.29308594539939 0.439130434782609 4.2 4 2 abnormal developmental patterning 0.000194827216172244 0.00377146070216698 1.29277368122518 0.439024390243902 4.2 4 2 decreased birth body size 1.29084308272238e-05 0.000382258591460943 1.29151366789066 0.43859649122807 4.2 4 2 incomplete embryo turning 0.00178792622920706 0.022575972056612 1.29151366789066 0.43859649122807 4.2 4 2 absent vitelline blood vessels 0.00178792622920706 0.022575972056612 1.29151366789066 0.43859649122807 4.2 4 2 prenatal lethality, incomplete penetrance 1.98293011984248e-12 1.89713025888776e-10 1.28828488372093 0.4375 4.2 4 2 abnormal intestinal epithelium morphology 0.00418264367285532 0.0434418627817437 1.28828488372093 0.4375 4.2 4 2 small heart 0.00418264367285532 0.0434418627817437 1.28828488372093 0.4375 4.2 4 2 abnormal osteoclast morphology 0.00418264367285532 0.0434418627817437 1.28828488372093 0.4375 4.2 4 2 polydipsia 0.0178609522229243 0.130866328879306 1.28828488372093 0.4375 4.2 4 2 increased fatty acid level 0.0178609522229243 0.130866328879306 1.28828488372093 0.4375 4.2 4 2 abnormal bone marrow cell number 0.084765777342105 0.383941163400339 1.28828488372093 0.4375 4.2 4 2 intraventricular hemorrhage 0.084765777342105 0.383941163400339 1.28828488372093 0.4375 4.2 4 2 abnormal olfaction 0.084765777342105 0.383941163400339 1.28828488372093 0.4375 4.2 4 2 increased pancreatic beta cell number 0.084765777342105 0.383941163400339 1.28828488372093 0.4375 4.2 4 2 abnormal molar crown morphology 0.084765777342105 0.383941163400339 1.28828488372093 0.4375 4.2 4 2 abnormal pulmonary alveolus wall morphology 0.084765777342105 0.383941163400339 1.28828488372093 0.4375 4.2 4 2 embryonic lethality between somite formation and embryo turning, incomplete penetrance 0.084765777342105 0.383941163400339 1.28828488372093 0.4375 4.2 4 2 decreased midbrain size 0.084765777342105 0.383941163400339 1.28828488372093 0.4375 4.2 4 2 abnormal retinal pigmentation 0.000149529198000769 0.00303635820430134 1.28616947340283 0.436781609195402 4.2 4 2 abnormal embryo turning 0.00237890588070259 0.0283049249248851 1.28493868921776 0.436363636363636 4.2 4 2 acanthosis 0.00992943746742007 0.0880551718367466 1.28356589147287 0.435897435897436 4.2 4 2 prenatal lethality 0.00136066821856522 0.0186997911253093 1.28234808702176 0.435483870967742 4.2 4 2 abnormal spermatogenesis 6.31101911738625e-08 3.21398273347996e-06 1.28028311425682 0.434782608695652 4.2 4 2 abnormal locomotor behavior 0.000114674385736152 0.00246907967515418 1.28028311425682 0.434782608695652 4.2 4 2 abnormal cardiovascular development 0.0444804630760773 0.263440837861291 1.28028311425682 0.434782608695652 4.2 4 2 decreased effector memory CD8-positive, alpha-beta T cell number 0.0444804630760773 0.263440837861291 1.28028311425682 0.434782608695652 4.2 4 2 increased mean corpuscular hemoglobin 6.6715983714731e-05 0.00154698896535165 1.2789898989899 0.434343434343434 4.2 4 2 abnormal coat/ hair morphology 0.0031645769998483 0.0356593368330153 1.27786748573936 0.433962264150943 4.2 4 2 gastrointestinal hemorrhage 0.024099218158441 0.169580778413358 1.27601550387597 0.433333333333333 4.2 4 2 disorganized myocardium 0.024099218158441 0.169580778413358 1.27601550387597 0.433333333333333 4.2 4 2 decreased white adipose tissue amount 0.00103509495020718 0.0147131353636592 1.27455050329747 0.432835820895522 4.2 4 2 increased erythroid progenitor cell number 0.0133120323018605 0.111870541725939 1.27336266499057 0.432432432432432 4.2 4 2 increased trabecular bone volume 0.0133120323018605 0.111870541725939 1.27336266499057 0.432432432432432 4.2 4 2 decreased sensitivity to induced morbidity/mortality 0.00744994112137506 0.0696681524038364 1.27155391120507 0.431818181818182 4.2 4 2 increased heart weight 3.49606490464039e-06 0.000118319203405347 1.27107244437009 0.431654676258993 4.2 4 2 abnormal seminiferous tubule morphology 2.05020306838651e-06 7.55537797423919e-05 1.27063714558777 0.431506849315068 4.2 4 2 abnormal forebrain development 0.000787272347075818 0.0117697117073055 1.26783591731266 0.430555555555556 4.2 4 2 abnormal visceral yolk sac morphology 0.000454063267163457 0.00758099804443154 1.26731822196055 0.430379746835443 4.2 4 2 lethality throughout fetal growth and development, incomplete penetrance 1.8795186218247e-07 8.42396859781791e-06 1.26669351695466 0.430167597765363 4.2 4 2 increased grip strength 0.000200429379712872 0.00384994657942679 1.26199335548173 0.428571428571429 4.2 4 2 arrest of spermatogenesis 0.000345949784875966 0.00608162607688315 1.26199335548173 0.428571428571429 4.2 4 2 decreased susceptibility to hepatic steatosis 0.00181240328296372 0.0228271046398595 1.26199335548173 0.428571428571429 4.2 4 2 abnormal somite shape 0.03253687148874 0.210964137244174 1.26199335548173 0.428571428571429 4.2 4 2 abnormal ovulation 0.03253687148874 0.210964137244174 1.26199335548173 0.428571428571429 4.2 4 2 hypoxia 0.03253687148874 0.210964137244174 1.26199335548173 0.428571428571429 4.2 4 2 abnormal salivary gland morphology 0.0607005103481459 0.315593996440641 1.26199335548173 0.428571428571429 4.2 4 2 trunk curl 0.0607005103481459 0.315593996440641 1.26199335548173 0.428571428571429 4.2 4 2 abnormal clavicle morphology 0.0607005103481459 0.315593996440641 1.26199335548173 0.428571428571429 4.2 4 2 midline facial cleft 0.117903574699023 0.47739976059354 1.26199335548173 0.428571428571429 4.2 4 2 abnormal blood flow velocity 0.117903574699023 0.47739976059354 1.26199335548173 0.428571428571429 4.2 4 2 abnormal ventral body wall morphology 0.117903574699023 0.47739976059354 1.26199335548173 0.428571428571429 4.2 4 2 abnormal positive T cell selection 0.117903574699023 0.47739976059354 1.26199335548173 0.428571428571429 4.2 4 2 abnormal iris pigmentation 0.117903574699023 0.47739976059354 1.26199335548173 0.428571428571429 4.2 4 2 abnormal glucose tolerance 0.117903574699023 0.47739976059354 1.26199335548173 0.428571428571429 4.2 4 2 spina bifida occulta 0.117903574699023 0.47739976059354 1.26199335548173 0.428571428571429 4.2 4 2 increased lung compliance 0.117903574699023 0.47739976059354 1.26199335548173 0.428571428571429 4.2 4 2 abnormal dermal layer morphology 0.0178489980168843 0.130866328879306 1.26199335548173 0.428571428571429 4.2 4 2 abnormal intestinal goblet cell morphology 0.0178489980168843 0.130866328879306 1.26199335548173 0.428571428571429 4.2 4 2 abnormal embryonic epiblast morphology 0.0178489980168843 0.130866328879306 1.26199335548173 0.428571428571429 4.2 4 2 holoprosencephaly 0.0178489980168843 0.130866328879306 1.26199335548173 0.428571428571429 4.2 4 2 increased red blood cell distribution width 0.0178489980168843 0.130866328879306 1.26199335548173 0.428571428571429 4.2 4 2 premature death 3.75341306738613e-29 2.33415375128075e-26 1.25515328309429 0.426248548199768 4.2 4 2 hepatic necrosis 0.007436927758399 0.0696681524038364 1.25304304799604 0.425531914893617 4.2 4 2 increased respiratory quotient 0.007436927758399 0.0696681524038364 1.25304304799604 0.425531914893617 4.2 4 2 impaired ovarian folliculogenesis 0.0132612653395388 0.111821686549501 1.25147674418605 0.425 4.2 4 2 decreased brown adipose tissue amount 0.0239337189017846 0.169133880023265 1.2492459478506 0.424242424242424 4.2 4 2 increased osteoblast cell number 0.0239337189017846 0.169133880023265 1.2492459478506 0.424242424242424 4.2 4 2 increased rib number 0.000787801808750295 0.0117697117073055 1.24581395348837 0.423076923076923 4.2 4 2 increased urine protein level 0.000787801808750295 0.0117697117073055 1.24581395348837 0.423076923076923 4.2 4 2 abnormal female meiosis 0.00557344297033082 0.0546900962078814 1.24581395348837 0.423076923076923 4.2 4 2 abnormal Mullerian duct morphology 0.0439561796759763 0.261894603458661 1.24581395348837 0.423076923076923 4.2 4 2 weight loss 7.19562462516115e-07 2.86385860081414e-05 1.24516677740864 0.422857142857143 4.2 4 2 increased circulating free fatty acid level 0.00136851234056364 0.0187557820779727 1.24421880117917 0.422535211267606 4.2 4 2 abnormal renal glomerulus morphology 8.88347075539182e-05 0.0019907777931565 1.24269682099424 0.422018348623853 4.2 4 2 abnormal extraembryonic tissue morphology 0.000152608620037749 0.00308629221417805 1.24137254901961 0.42156862745098 4.2 4 2 decreased fertilization frequency 0.0829945838286386 0.381959347407472 1.23985312117503 0.421052631578947 4.2 4 2 embryonic lethality between implantation and somite formation, incomplete penetrance 0.0829945838286386 0.381959347407472 1.23985312117503 0.421052631578947 4.2 4 2 abnormal interventricular septum morphology 0.00737842411464217 0.0693906615696499 1.23675348837209 0.42 4.2 4 2 decreased oocyte number 0.00737842411464217 0.0693906615696499 1.23675348837209 0.42 4.2 4 2 abnormal neural tube morphology 2.70749382882706e-06 9.55303673646429e-05 1.23602641401091 0.419753086419753 4.2 4 2 osteopetrosis 0.0320922974152162 0.21007786794829 1.23485371342836 0.419354838709677 4.2 4 2 preaxial polydactyly 0.0320922974152162 0.21007786794829 1.23485371342836 0.419354838709677 4.2 4 2 small seminiferous tubules 0.00135936227315329 0.0186997911253093 1.23357008170962 0.418918918918919 4.2 4 2 abnormal learning/memory/conditioning 0.00552193654156371 0.0542917673799989 1.23139957716702 0.418181818181818 4.2 4 2 enlarged heart 2.95252076017467e-08 1.63208786465211e-06 1.23116880513232 0.418103448275862 4.2 4 2 abnormal testis morphology 8.7846102793707e-05 0.00197753104705291 1.22907178968655 0.417391304347826 4.2 4 2 overriding aortic valve 0.0097614163909302 0.0875289225082849 1.22693798449612 0.416666666666667 4.2 4 2 abnormal kidney physiology 0.0097614163909302 0.0875289225082849 1.22693798449612 0.416666666666667 4.2 4 2 abnormal adrenal gland morphology 0.0594183953574619 0.315593996440641 1.22693798449612 0.416666666666667 4.2 4 2 abnormal tumor morphology 0.0594183953574619 0.315593996440641 1.22693798449612 0.416666666666667 4.2 4 2 increased body temperature 0.0594183953574619 0.315593996440641 1.22693798449612 0.416666666666667 4.2 4 2 amyloidosis 0.164933243453693 0.585983342034419 1.22693798449612 0.416666666666667 4.2 4 2 increased papilloma incidence 0.164933243453693 0.585983342034419 1.22693798449612 0.416666666666667 4.2 4 2 delayed somite formation 0.164933243453693 0.585983342034419 1.22693798449612 0.416666666666667 4.2 4 2 decreased left ventricle systolic pressure 0.164933243453693 0.585983342034419 1.22693798449612 0.416666666666667 4.2 4 2 abnormal defecation 0.164933243453693 0.585983342034419 1.22693798449612 0.416666666666667 4.2 4 2 increased hepatocyte proliferation 0.164933243453693 0.585983342034419 1.22693798449612 0.416666666666667 4.2 4 2 stria vascularis degeneration 0.164933243453693 0.585983342034419 1.22693798449612 0.416666666666667 4.2 4 2 abnormal cochlear outer hair cell physiology 0.164933243453693 0.585983342034419 1.22693798449612 0.416666666666667 4.2 4 2 hematuria 0.164933243453693 0.585983342034419 1.22693798449612 0.416666666666667 4.2 4 2 abnormal fatty acid level 0.164933243453693 0.585983342034419 1.22693798449612 0.416666666666667 4.2 4 2 decreased renal glomerular filtration rate 0.164933243453693 0.585983342034419 1.22693798449612 0.416666666666667 4.2 4 2 abnormal pulmonary valve cusp morphology 0.164933243453693 0.585983342034419 1.22693798449612 0.416666666666667 4.2 4 2 absent mesoderm 0.00414022925959227 0.0432723541312428 1.22693798449612 0.416666666666667 4.2 4 2 increased bone mineral density 0.000114498707345751 0.00246907967515418 1.22476641284215 0.415929203539823 4.2 4 2 preweaning lethality, incomplete penetrance 4.36674664875418e-13 4.52595095365668e-11 1.22393813612327 0.415647921760391 4.2 4 2 hemopericardium 0.01740769516839 0.129258632033941 1.22095292115712 0.414634146341463 4.2 4 2 increased bone trabecula number 0.01740769516839 0.129258632033941 1.22095292115712 0.414634146341463 4.2 4 2 reduced female fertility 6.33106146494545e-08 3.21398273347996e-06 1.21847634322374 0.413793103448276 4.2 4 2 decreased trophoblast giant cell number 0.0430268447301086 0.259150789990666 1.21847634322374 0.413793103448276 4.2 4 2 gliosis 0.00408098084125144 0.043235336114652 1.21525286083426 0.412698412698413 4.2 4 2 cochlear inner hair cell degeneration 0.00959724074877924 0.0864968708789433 1.21250341997264 0.411764705882353 4.2 4 2 lung hemorrhage 0.0314152846665636 0.206188708728435 1.21250341997264 0.411764705882353 4.2 4 2 abnormal brown adipose tissue morphology 0.0314152846665636 0.206188708728435 1.21250341997264 0.411764705882353 4.2 4 2 increased incidence of corneal inflammation 0.113714214195125 0.47420638358822 1.21250341997264 0.411764705882353 4.2 4 2 hyperlipidemia 0.113714214195125 0.47420638358822 1.21250341997264 0.411764705882353 4.2 4 2 abnormal survival 0.113714214195125 0.47420638358822 1.21250341997264 0.411764705882353 4.2 4 2 abnormal cornea morphology 0.0017335823277494 0.0222857159704219 1.20806201550388 0.41025641025641 4.2 4 2 failure of heart looping 0.0230816960236575 0.16404491102528 1.20806201550388 0.41025641025641 4.2 4 2 increased osteoclast cell number 0.00535109519813354 0.0527162348727017 1.20682424704537 0.409836065573771 4.2 4 2 teratozoospermia 0.000985875968631434 0.0140722637182903 1.20463002114165 0.409090909090909 4.2 4 2 abnormal abdominal fat pad morphology 0.0803610448365504 0.378236705829554 1.20463002114165 0.409090909090909 4.2 4 2 abnormal tail movements 0.0803610448365504 0.378236705829554 1.20463002114165 0.409090909090909 4.2 4 2 abnormal germ layer development 0.0803610448365504 0.378236705829554 1.20463002114165 0.409090909090909 4.2 4 2 abnormal oogenesis 0.0803610448365504 0.378236705829554 1.20463002114165 0.409090909090909 4.2 4 2 increased skin papilloma incidence 0.0803610448365504 0.378236705829554 1.20463002114165 0.409090909090909 4.2 4 2 increased coping response 0.0803610448365504 0.378236705829554 1.20463002114165 0.409090909090909 4.2 4 2 parakeratosis 0.0803610448365504 0.378236705829554 1.20463002114165 0.409090909090909 4.2 4 2 abnormal circulating lipid level 0.0803610448365504 0.378236705829554 1.20463002114165 0.409090909090909 4.2 4 2 decreased circulating estradiol level 0.0803610448365504 0.378236705829554 1.20463002114165 0.409090909090909 4.2 4 2 pulmonary vascular congestion 0.0803610448365504 0.378236705829554 1.20463002114165 0.409090909090909 4.2 4 2 increased bone volume 0.0803610448365504 0.378236705829554 1.20463002114165 0.409090909090909 4.2 4 2 abnormal small intestine morphology 0.00939728621814337 0.0848484554179007 1.19967269595177 0.407407407407407 4.2 4 2 abnormal atrioventricular cushion morphology 0.0576714217474608 0.310647943580942 1.19967269595177 0.407407407407407 4.2 4 2 increased brain weight 0.0576714217474608 0.310647943580942 1.19967269595177 0.407407407407407 4.2 4 2 decreased bone ossification 0.0576714217474608 0.310647943580942 1.19967269595177 0.407407407407407 4.2 4 2 abnormal blood vessel morphology 3.61588490089468e-05 0.000913148598068581 1.19816840417001 0.406896551724138 4.2 4 2 small ovary 0.000967626689169149 0.0138730339441398 1.19727574750831 0.406593406593407 4.2 4 2 scoliosis 0.0418295335994157 0.252550885506181 1.19626453488372 0.40625 4.2 4 2 abnormal calcium ion homeostasis 0.030576700300479 0.202825445326511 1.19377749842866 0.405405405405405 4.2 4 2 decreased body length 2.47843330221661e-08 1.38541636837389e-06 1.19290612799185 0.405109489051095 4.2 4 2 abnormal heart development 2.0537478296659e-05 0.000561395354537795 1.19277009125699 0.40506329113924 4.2 4 2 abnormal bone structure 3.04926785213637e-06 0.000104621431478472 1.19006627304495 0.404145077720207 4.2 4 2 distended pericardium 0.0123230392438572 0.105338694567336 1.18918604651163 0.403846153846154 4.2 4 2 abnormal skin condition 0.0123230392438572 0.105338694567336 1.18918604651163 0.403846153846154 4.2 4 2 abnormal eye morphology 7.77331864921021e-05 0.00176585663378177 1.18633428141208 0.402877697841727 4.2 4 2 cochlear outer hair cell degeneration 0.00383423878274963 0.0415584704666218 1.18604005167959 0.402777777777778 4.2 4 2 perinatal lethality, incomplete penetrance 5.87043141127787e-07 2.43378302259229e-05 1.18567812307059 0.402654867256637 4.2 4 2 small testis 3.93131216607439e-08 2.0806678751298e-06 1.18426188068756 0.402173913043478 4.2 4 2 postnatal growth retardation 6.81485528366756e-16 1.05949703238269e-13 1.17882276941784 0.400326797385621 4.2 4 2 neonatal lethality, incomplete penetrance 1.42165969142659e-07 6.54884904152526e-06 1.17786046511628 0.4 4.2 4 2 cardiomyopathy 0.0218181422562851 0.155955830064682 1.17786046511628 0.4 4.2 4 2 abnormal pancreatic beta cell morphology 0.02962864981307 0.196799109239016 1.17786046511628 0.4 4.2 4 2 abnormal pericardium morphology 0.108725053166963 0.45602851153922 1.17786046511628 0.4 4.2 4 2 abnormal cell proliferation 0.108725053166963 0.45602851153922 1.17786046511628 0.4 4.2 4 2 small gonad 0.108725053166963 0.45602851153922 1.17786046511628 0.4 4.2 4 2 abnormal circulating enzyme level 0.108725053166963 0.45602851153922 1.17786046511628 0.4 4.2 4 2 abnormal hair texture 0.108725053166963 0.45602851153922 1.17786046511628 0.4 4.2 4 2 absent placental labyrinth 0.108725053166963 0.45602851153922 1.17786046511628 0.4 4.2 4 2 dilated vasculature 0.108725053166963 0.45602851153922 1.17786046511628 0.4 4.2 4 2 abnormal induced retinal neovascularization 0.108725053166963 0.45602851153922 1.17786046511628 0.4 4.2 4 2 abnormal sperm mitochondrial sheath morphology 0.108725053166963 0.45602851153922 1.17786046511628 0.4 4.2 4 2 absent ductus venosus valve 0.108725053166963 0.45602851153922 1.17786046511628 0.4 4.2 4 2 thick pulmonary interalveolar septum 0.0404594757663496 0.24788902947979 1.17786046511628 0.4 4.2 4 2 increased circulating serum albumin level 0.0404594757663496 0.24788902947979 1.17786046511628 0.4 4.2 4 2 abnormal hippocampus pyramidal cell morphology 0.0404594757663496 0.24788902947979 1.17786046511628 0.4 4.2 4 2 decreased bone volume 0.0404594757663496 0.24788902947979 1.17786046511628 0.4 4.2 4 2 liver hemorrhage 0.0556452624445536 0.304214484243576 1.17786046511628 0.4 4.2 4 2 abnormal optic cup morphology 0.0556452624445536 0.304214484243576 1.17786046511628 0.4 4.2 4 2 abnormal egg cylinder morphology 0.0772628350526525 0.368182571251864 1.17786046511628 0.4 4.2 4 2 decreased salivation 0.156151598613645 0.575886594360896 1.17786046511628 0.4 4.2 4 2 hyperpigmentation 0.156151598613645 0.575886594360896 1.17786046511628 0.4 4.2 4 2 audiogenic seizures 0.156151598613645 0.575886594360896 1.17786046511628 0.4 4.2 4 2 abnormal bronchus morphology 0.156151598613645 0.575886594360896 1.17786046511628 0.4 4.2 4 2 abnormal olfactory nerve morphology 0.156151598613645 0.575886594360896 1.17786046511628 0.4 4.2 4 2 immune system phenotype 0.156151598613645 0.575886594360896 1.17786046511628 0.4 4.2 4 2 abnormal Muller cell morphology 0.156151598613645 0.575886594360896 1.17786046511628 0.4 4.2 4 2 abnormal coronary vessel morphology 0.156151598613645 0.575886594360896 1.17786046511628 0.4 4.2 4 2 decreased trabecular bone mass 0.156151598613645 0.575886594360896 1.17786046511628 0.4 4.2 4 2 heterochrony 0.156151598613645 0.575886594360896 1.17786046511628 0.4 4.2 4 2 decreased brown adipose tissue mass 0.156151598613645 0.575886594360896 1.17786046511628 0.4 4.2 4 2 perinatal lethality, complete penetrance 2.08486624036307e-06 7.62662466603401e-05 1.17509553444699 0.39906103286385 4.2 4 2 abnormal cardiovascular system physiology 0.000165805356963465 0.00332217844218577 1.17343241825494 0.398496240601504 4.2 4 2 decreased circulating HDL cholesterol level 0.000218661305604139 0.00416796933096012 1.17325944767442 0.3984375 4.2 4 2 hypoglycemia 0.00154709855522711 0.0200437898756637 1.17152788197049 0.397849462365591 4.2 4 2 ventricular septal defect 0.000161564316356952 0.00325418005617748 1.16919972640219 0.397058823529412 4.2 4 2 increased circulating bilirubin level 0.0156305907516221 0.123400283791971 1.16674857393594 0.39622641509434 4.2 4 2 decreased heart weight 0.00352645463172981 0.0389869150952351 1.16331897789262 0.395061728395062 4.2 4 2 abnormal lung morphology 0.000476459342819685 0.00779731983726294 1.16301348446355 0.394957983193277 4.2 4 2 decreased total retina thickness 0.0389837455127837 0.243589828690197 1.16236230110159 0.394736842105263 4.2 4 2 decreased circulating glucose level 1.5235410741793e-07 6.89056076731093e-06 1.16097357672752 0.39426523297491 4.2 4 2 belly spot 0.0534618131528759 0.293244234217815 1.1600140944327 0.393939393939394 4.2 4 2 diarrhea 0.0534618131528759 0.293244234217815 1.1600140944327 0.393939393939394 4.2 4 2 abnormal circulating cholesterol level 0.0739349542678094 0.352661934307144 1.15682724252492 0.392857142857143 4.2 4 2 abnormal retinal inner nuclear layer morphology 0.0739349542678094 0.352661934307144 1.15682724252492 0.392857142857143 4.2 4 2 abnormal brainstem morphology 0.0739349542678094 0.352661934307144 1.15682724252492 0.392857142857143 4.2 4 2 abnormal renal tubule epithelium morphology 0.0739349542678094 0.352661934307144 1.15682724252492 0.392857142857143 4.2 4 2 perimembraneous ventricular septal defect 0.00810407296041083 0.0749756504145741 1.15225480283114 0.391304347826087 4.2 4 2 abnormal postnatal growth 0.10342713311114 0.454013620126724 1.15225480283114 0.391304347826087 4.2 4 2 conjunctivitis 0.10342713311114 0.454013620126724 1.15225480283114 0.391304347826087 4.2 4 2 increased susceptibility to fungal infection 0.10342713311114 0.454013620126724 1.15225480283114 0.391304347826087 4.2 4 2 abnormal vertebral artery topology 0.10342713311114 0.454013620126724 1.15225480283114 0.391304347826087 4.2 4 2 decreased circulating LDL cholesterol level 0.0108493517783917 0.0945280649693498 1.15025436046512 0.390625 4.2 4 2 abnormal tooth morphology 0.0108493517783917 0.0945280649693498 1.15025436046512 0.390625 4.2 4 2 sparse hair 0.00439852714874759 0.0453997356120732 1.14913216108905 0.390243902439024 4.2 4 2 abnormal mammary gland development 0.0374500607856652 0.237342741921891 1.14913216108905 0.390243902439024 4.2 4 2 scaly skin 0.0374500607856652 0.237342741921891 1.14913216108905 0.390243902439024 4.2 4 2 cleft palate 0.000421262261737853 0.00725183305240767 1.14639091070478 0.389312977099237 4.2 4 2 diluted coat color 0.0195972390911085 0.142330313106956 1.14514211886305 0.388888888888889 4.2 4 2 impaired wound healing 0.05120254452683 0.290072777029703 1.14514211886305 0.388888888888889 4.2 4 2 underdeveloped hair follicles 0.147114698456768 0.568683469170489 1.14514211886305 0.388888888888889 4.2 4 2 abnormal phrenic nerve morphology 0.147114698456768 0.568683469170489 1.14514211886305 0.388888888888889 4.2 4 2 thick dermal layer 0.147114698456768 0.568683469170489 1.14514211886305 0.388888888888889 4.2 4 2 abnormal glycogen homeostasis 0.147114698456768 0.568683469170489 1.14514211886305 0.388888888888889 4.2 4 2 decreased lactate dehydrogenase level 0.147114698456768 0.568683469170489 1.14514211886305 0.388888888888889 4.2 4 2 atrioventricular block 0.147114698456768 0.568683469170489 1.14514211886305 0.388888888888889 4.2 4 2 increased adipocyte glucose uptake 0.147114698456768 0.568683469170489 1.14514211886305 0.388888888888889 4.2 4 2 abnormal podocyte morphology 0.0705208193051878 0.344299387677438 1.13986496624156 0.387096774193548 4.2 4 2 insulin resistance 0.000519205867343752 0.00844133722233714 1.13770613107822 0.386363636363636 4.2 4 2 decreased total body fat amount 5.63286780570305e-08 2.91911638889299e-06 1.13730538922156 0.38622754491018 4.2 4 2 increased blood urea nitrogen level 0.000289009845817591 0.00524753278446174 1.13724458700882 0.386206896551724 4.2 4 2 retinal degeneration 0.00297349109151939 0.0345932372678107 1.13491763565891 0.385416666666667 4.2 4 2 cachexia 0.00216274179448424 0.0265670134013804 1.13255813953488 0.384615384615385 4.2 4 2 decreased monocyte cell number 0.0134672834371116 0.112640598444521 1.13255813953488 0.384615384615385 4.2 4 2 decreased circulating glycerol level 0.098079494663075 0.436444978487297 1.13255813953488 0.384615384615385 4.2 4 2 short premaxilla 0.21491109085047 0.641832829137905 1.13255813953488 0.384615384615385 4.2 4 2 absent myocardial trabeculae 0.21491109085047 0.641832829137905 1.13255813953488 0.384615384615385 4.2 4 2 abnormal pulmonary alveolus epithelial cell morphology 0.21491109085047 0.641832829137905 1.13255813953488 0.384615384615385 4.2 4 2 abnormal bile duct development 0.21491109085047 0.641832829137905 1.13255813953488 0.384615384615385 4.2 4 2 increased cochlear inner hair cell number 0.21491109085047 0.641832829137905 1.13255813953488 0.384615384615385 4.2 4 2 increased circulating thyroxine level 0.21491109085047 0.641832829137905 1.13255813953488 0.384615384615385 4.2 4 2 increased prostaglandin level 0.21491109085047 0.641832829137905 1.13255813953488 0.384615384615385 4.2 4 2 abnormal aorta tunica media morphology 0.21491109085047 0.641832829137905 1.13255813953488 0.384615384615385 4.2 4 2 abnormal neuron morphology 0.00286406894936941 0.0335264541720301 1.1302701432934 0.383838383838384 4.2 4 2 male infertility 6.4834853565697e-11 4.96235994598989e-09 1.1298562115678 0.383697813121272 4.2 4 2 epidermal hyperplasia 0.0180656087635003 0.132171181762373 1.12878294573643 0.383333333333333 4.2 4 2 abnormal nervous system physiology 0.0015173441097494 0.0197362192046489 1.12664914054601 0.382608695652174 4.2 4 2 abnormal skeleton morphology 0.0015173441097494 0.0197362192046489 1.12664914054601 0.382608695652174 4.2 4 2 thin skin 0.0671096641205933 0.328936531034435 1.12589603283174 0.382352941176471 4.2 4 2 abnormal nervous system development 0.0671096641205933 0.328936531034435 1.12589603283174 0.382352941176471 4.2 4 2 decreased rib number 0.00503816141974861 0.0499299861817715 1.12492291612229 0.382022471910112 4.2 4 2 increased circulating calcium level 0.024301477763466 0.170762502645824 1.12432135306554 0.381818181818182 4.2 4 2 abnormal myocardial fiber morphology 0.00365029252922602 0.0402665306716174 1.123217453848 0.381443298969072 4.2 4 2 decreased inflammatory response 0.00669394295409371 0.0636756523835874 1.12177187153931 0.380952380952381 4.2 4 2 skin lesions 0.0173094705665983 0.128914095911417 1.12177187153931 0.380952380952381 4.2 4 2 disheveled coat 0.0466591592035503 0.275360992927239 1.12177187153931 0.380952380952381 4.2 4 2 abnormal reproductive system morphology 0.0466591592035503 0.275360992927239 1.12177187153931 0.380952380952381 4.2 4 2 increased vasoconstriction 0.138278617978543 0.541934158846874 1.12177187153931 0.380952380952381 4.2 4 2 vascular ring 0.138278617978543 0.541934158846874 1.12177187153931 0.380952380952381 4.2 4 2 abnormal skeletal muscle fiber morphology 0.0123910284501403 0.105557134485356 1.11979692106125 0.380281690140845 4.2 4 2 decreased respiratory quotient 0.0327973380002669 0.21141029455965 1.11896744186046 0.38 4.2 4 2 cochlear ganglion degeneration 0.0232385896310927 0.164924370063746 1.11693664795509 0.379310344827586 4.2 4 2 abnormal outer ear morphology 0.092823243429738 0.415885386895417 1.11693664795509 0.379310344827586 4.2 4 2 enlarged epididymis 0.092823243429738 0.415885386895417 1.11693664795509 0.379310344827586 4.2 4 2 impaired glucose tolerance 8.20865329945761e-06 0.000252086729412356 1.11611777944486 0.379032258064516 4.2 4 2 alopecia 0.00464435451943996 0.0472508460822368 1.11586780905753 0.378947368421053 4.2 4 2 decreased circulating chloride level 0.0637574062298261 0.315593996440641 1.11419233186675 0.378378378378378 4.2 4 2 decreased body weight 4.93332425558137e-23 1.53664398272137e-20 1.113163767517 0.378029079159935 4.2 4 2 thin ventricular wall 0.0061570346372232 0.0592225471673703 1.11242377260982 0.377777777777778 4.2 4 2 lethality at weaning, complete penetrance 0.0444377781115386 0.263440837861291 1.11242377260982 0.377777777777778 4.2 4 2 abnormal kidney morphology 0.000198723480471835 0.00383197409049371 1.11055415282392 0.377142857142857 4.2 4 2 decreased eosinophil cell number 0.0211855418395224 0.151651900218164 1.10424418604651 0.375 4.2 4 2 abnormal crypts of Lieberkuhn morphology 0.0877355907286512 0.395008655090534 1.10424418604651 0.375 4.2 4 2 increased circulating follicle stimulating hormone level 0.0877355907286512 0.395008655090534 1.10424418604651 0.375 4.2 4 2 abnormal startle reflex 0.129832375763347 0.512225273134537 1.10424418604651 0.375 4.2 4 2 abnormal vasodilation 0.129832375763347 0.512225273134537 1.10424418604651 0.375 4.2 4 2 increased circulating total protein level 0.129832375763347 0.512225273134537 1.10424418604651 0.375 4.2 4 2 absent mandible 0.19898309137657 0.641832829137905 1.10424418604651 0.375 4.2 4 2 failure of tooth eruption 0.19898309137657 0.641832829137905 1.10424418604651 0.375 4.2 4 2 abnormal hair follicle orientation 0.19898309137657 0.641832829137905 1.10424418604651 0.375 4.2 4 2 mixed cellular infiltration to dermis 0.19898309137657 0.641832829137905 1.10424418604651 0.375 4.2 4 2 abnormal epicardium morphology 0.19898309137657 0.641832829137905 1.10424418604651 0.375 4.2 4 2 paternal imprinting 0.19898309137657 0.641832829137905 1.10424418604651 0.375 4.2 4 2 small epididymis 0.19898309137657 0.641832829137905 1.10424418604651 0.375 4.2 4 2 increased thymus weight 0.19898309137657 0.641832829137905 1.10424418604651 0.375 4.2 4 2 decreased circulating prolactin level 0.19898309137657 0.641832829137905 1.10424418604651 0.375 4.2 4 2 kidney degeneration 0.19898309137657 0.641832829137905 1.10424418604651 0.375 4.2 4 2 increased heart left ventricle size 0.19898309137657 0.641832829137905 1.10424418604651 0.375 4.2 4 2 abnormal liver morphology 0.000230310969099486 0.00437327126438909 1.1021878654021 0.374301675977654 4.2 4 2 double outlet right ventricle 0.00391406935810996 0.0423315109926023 1.10080417300587 0.373831775700935 4.2 4 2 kyphosis 0.000768519794255975 0.0115860181103742 1.09933643410853 0.373333333333333 4.2 4 2 delayed bone ossification 0.0144479068413972 0.118415710932374 1.09933643410853 0.373333333333333 4.2 4 2 abnormal neurocranium morphology 0.0144479068413972 0.118415710932374 1.09933643410853 0.373333333333333 4.2 4 2 increased hemoglobin content 0.0283985982744939 0.19453000851625 1.09800551832873 0.372881355932203 4.2 4 2 abnormal brain morphology 0.000538600348556207 0.00867163991607485 1.09738552650585 0.372670807453416 4.2 4 2 abnormal gastrulation 0.040182941795014 0.247413533948261 1.09702690378477 0.372549019607843 4.2 4 2 small lung 0.040182941795014 0.247413533948261 1.09702690378477 0.372549019607843 4.2 4 2 decreased body size 4.54932010711656e-14 5.26345756579184e-12 1.0959415981815 0.37218045112782 4.2 4 2 abnormal left-right axis patterning 0.0573551197098144 0.310647943580942 1.09568415359654 0.372093023255814 4.2 4 2 decreased oxygen consumption 0.0573551197098144 0.310647943580942 1.09568415359654 0.372093023255814 4.2 4 2 no abnormal phenotype detected 3.52882856341607e-29 2.33415375128075e-26 1.09469740634006 0.371757925072046 4.2 4 2 decreased circulating cholesterol level 0.000265349382444092 0.00489123166289244 1.09418731732113 0.371584699453552 4.2 4 2 increased circulating HDL cholesterol level 0.00493867795666141 0.0493639587027846 1.09372757475083 0.371428571428571 4.2 4 2 abnormal midbrain development 0.0828575026935552 0.381959347407472 1.09372757475083 0.371428571428571 4.2 4 2 impaired adaptive thermogenesis 0.0828575026935552 0.381959347407472 1.09372757475083 0.371428571428571 4.2 4 2 decreased bone mineralization 0.0828575026935552 0.381959347407472 1.09372757475083 0.371428571428571 4.2 4 2 abnormal heart valve morphology 0.121848949319319 0.483797703801764 1.09061154177433 0.37037037037037 4.2 4 2 abnormal type II pneumocyte morphology 0.121848949319319 0.483797703801764 1.09061154177433 0.37037037037037 4.2 4 2 decreased bone mineral content 0.00012563384656857 0.00265969526246228 1.09008720930233 0.370192307692308 4.2 4 2 enlarged liver 0.00651657414976606 0.0621071961591688 1.08952093023256 0.37 4.2 4 2 decreased percent body fat/body weight 0.0183390806256131 0.133974928212078 1.08911755336094 0.36986301369863 4.2 4 2 atrial septal defect 0.0543382934812531 0.297723579371403 1.0882406471183 0.369565217391304 4.2 4 2 abnormal lipid homeostasis 0.00227449208834254 0.0275990198524492 1.08725581395349 0.369230769230769 4.2 4 2 abnormal craniofacial morphology 0.00621937714165868 0.0593884861415584 1.08637615714608 0.368932038834951 4.2 4 2 persistence of hyaloid vascular system 0.0782087083147675 0.372333324273654 1.08487148102815 0.368421052631579 4.2 4 2 abnormal triglyceride level 0.18451809865651 0.613211450110979 1.08487148102815 0.368421052631579 4.2 4 2 thin dermal layer 0.18451809865651 0.613211450110979 1.08487148102815 0.368421052631579 4.2 4 2 decreased germ cell number 0.18451809865651 0.613211450110979 1.08487148102815 0.368421052631579 4.2 4 2 abnormal nasal septum morphology 0.18451809865651 0.613211450110979 1.08487148102815 0.368421052631579 4.2 4 2 abnormal neural crest cell migration 0.18451809865651 0.613211450110979 1.08487148102815 0.368421052631579 4.2 4 2 abnormal metatarsal bone morphology 0.18451809865651 0.613211450110979 1.08487148102815 0.368421052631579 4.2 4 2 abnormal optic vesicle formation 0.18451809865651 0.613211450110979 1.08487148102815 0.368421052631579 4.2 4 2 abnormal sternebra morphology 0.18451809865651 0.613211450110979 1.08487148102815 0.368421052631579 4.2 4 2 absent amnion 0.18451809865651 0.613211450110979 1.08487148102815 0.368421052631579 4.2 4 2 increased circulating VLDL cholesterol level 0.18451809865651 0.613211450110979 1.08487148102815 0.368421052631579 4.2 4 2 decreased eye pigmentation 0.18451809865651 0.613211450110979 1.08487148102815 0.368421052631579 4.2 4 2 decreased liver regeneration 0.18451809865651 0.613211450110979 1.08487148102815 0.368421052631579 4.2 4 2 increased liver cholesterol level 0.18451809865651 0.613211450110979 1.08487148102815 0.368421052631579 4.2 4 2 decreased circulating magnesium level 0.18451809865651 0.613211450110979 1.08487148102815 0.368421052631579 4.2 4 2 decreased susceptibility to weight gain 0.18451809865651 0.613211450110979 1.08487148102815 0.368421052631579 4.2 4 2 polydactyly 0.00820195046910905 0.075046080571084 1.08170859041291 0.36734693877551 4.2 4 2 reduced fertility 0.00198206075519661 0.0245292344704058 1.08041157771457 0.366906474820144 4.2 4 2 abnormal pulmonary alveolus morphology 0.00781608716866213 0.0728184151012998 1.07873359428966 0.366336633663366 4.2 4 2 thick ventricular wall 0.0737962322117805 0.352661934307144 1.07731140102099 0.365853658536585 4.2 4 2 liver fibrosis 0.0737962322117805 0.352661934307144 1.07731140102099 0.365853658536585 4.2 4 2 abnormal cholesterol homeostasis 0.0737962322117805 0.352661934307144 1.07731140102099 0.365853658536585 4.2 4 2 eyelids open at birth 0.048705534876671 0.287097199065685 1.07593023255814 0.365384615384615 4.2 4 2 increased circulating aspartate transaminase level 0.0326117498451899 0.210964137244174 1.07503137689184 0.365079365079365 4.2 4 2 abnormal lung development 0.0150299578771653 0.122580394162127 1.0739316005472 0.364705882352941 4.2 4 2 cardiac fibrosis 0.0150299578771653 0.122580394162127 1.0739316005472 0.364705882352941 4.2 4 2 female infertility 3.65530890168346e-05 0.000918442514438143 1.0738013638748 0.364661654135338 4.2 4 2 increased sensitivity to induced morbidity/mortality 0.000560963001794371 0.00888550237641618 1.07223710819009 0.364130434782609 4.2 4 2 abnormal motor coordination/ balance 0.00980137402654432 0.0875289225082849 1.0707822410148 0.363636363636364 4.2 4 2 abnormal head morphology 0.0460908909546601 0.272654200356045 1.0707822410148 0.363636363636364 4.2 4 2 cochlear hair cell degeneration 0.0696194267759951 0.340232463861076 1.0707822410148 0.363636363636364 4.2 4 2 embryonic lethality, incomplete penetrance 0.0696194267759951 0.340232463861076 1.0707822410148 0.363636363636364 4.2 4 2 abnormal tooth development 0.107320606486237 0.454013620126724 1.0707822410148 0.363636363636364 4.2 4 2 enlarged pericardium 0.107320606486237 0.454013620126724 1.0707822410148 0.363636363636364 4.2 4 2 decreased systemic arterial blood pressure 0.107320606486237 0.454013620126724 1.0707822410148 0.363636363636364 4.2 4 2 abnormal QRS complex 0.107320606486237 0.454013620126724 1.0707822410148 0.363636363636364 4.2 4 2 cardiovascular system phenotype 0.107320606486237 0.454013620126724 1.0707822410148 0.363636363636364 4.2 4 2 decreased sensitivity to xenobiotic induced morbidity/mortality 0.107320606486237 0.454013620126724 1.0707822410148 0.363636363636364 4.2 4 2 abnormal enterocyte morphology 0.171374374059682 0.58947006189941 1.0707822410148 0.363636363636364 4.2 4 2 intracerebral hemorrhage 0.171374374059682 0.58947006189941 1.0707822410148 0.363636363636364 4.2 4 2 testis hypoplasia 0.171374374059682 0.58947006189941 1.0707822410148 0.363636363636364 4.2 4 2 aphakia 0.171374374059682 0.58947006189941 1.0707822410148 0.363636363636364 4.2 4 2 prolonged PR interval 0.171374374059682 0.58947006189941 1.0707822410148 0.363636363636364 4.2 4 2 cleft upper lip 0.171374374059682 0.58947006189941 1.0707822410148 0.363636363636364 4.2 4 2 abnormal cerebral cortex pyramidal cell morphology 0.171374374059682 0.58947006189941 1.0707822410148 0.363636363636364 4.2 4 2 rough coat 0.171374374059682 0.58947006189941 1.0707822410148 0.363636363636364 4.2 4 2 decreased litter size 2.90962428600185e-05 0.000772994827029911 1.06887693453613 0.362989323843416 4.2 4 2 abnormal rib morphology 0.0030852892731331 0.0352048489308192 1.06879931093885 0.362962962962963 4.2 4 2 increased thermal nociceptive threshold 0.013581665833153 0.112640598444521 1.06784053156146 0.362637362637363 4.2 4 2 abnormal neuromuscular synapse morphology 0.0277896792341409 0.19228602808046 1.06334625322997 0.361111111111111 4.2 4 2 abnormal uterus morphology 0.1007494355704 0.44752539460959 1.06334625322997 0.361111111111111 4.2 4 2 abnormal epidermis stratum granulosum morphology 0.1007494355704 0.44752539460959 1.06334625322997 0.361111111111111 4.2 4 2 decreased grip strength 0.000270111574363853 0.00494045986198592 1.06222576191993 0.360730593607306 4.2 4 2 abnormal maternal nurturing 0.0412530206117279 0.249372755216703 1.06200533739992 0.360655737704918 4.2 4 2 abnormal male meiosis 0.0412530206117279 0.249372755216703 1.06200533739992 0.360655737704918 4.2 4 2 increased body length 0.0619490442392864 0.315593996440641 1.06007441860465 0.36 4.2 4 2 ruffled hair 0.159402742413113 0.575886594360896 1.06007441860465 0.36 4.2 4 2 increased or absent threshold for auditory brainstem response 3.67811647590871e-05 0.000919529118977177 1.05966685442987 0.359861591695502 4.2 4 2 abnormal behavior 5.21964838265513e-05 0.00123655955731949 1.05922703697507 0.359712230215827 4.2 4 2 increased startle reflex 0.0170019216529573 0.127003844179373 1.0587509798798 0.359550561797753 4.2 4 2 abnormal muscle physiology 0.0170019216529573 0.127003844179373 1.0587509798798 0.359550561797753 4.2 4 2 abnormal response to injury 0.0946089701626843 0.42289274623482 1.05705426356589 0.358974358974359 4.2 4 2 abnormal circulating hormone level 0.0946089701626843 0.42289274623482 1.05705426356589 0.358974358974359 4.2 4 2 enlarged kidney 0.0584379660402438 0.312948203498614 1.05562966213251 0.358490566037736 4.2 4 2 atrioventricular septal defect 0.0584379660402438 0.312948203498614 1.05562966213251 0.358490566037736 4.2 4 2 abnormal retina morphology 0.000531760732614916 0.00858931702843899 1.05166112956811 0.357142857142857 4.2 4 2 limb grasping 0.00119561364126979 0.0166615626479473 1.05166112956811 0.357142857142857 4.2 4 2 abnormal pancreas morphology 0.0888723838830193 0.399403893241212 1.05166112956811 0.357142857142857 4.2 4 2 abnormal muscle morphology 0.0888723838830193 0.399403893241212 1.05166112956811 0.357142857142857 4.2 4 2 reddish skin 0.148467835459046 0.572361176931318 1.05166112956811 0.357142857142857 4.2 4 2 absent corpus callosum 0.148467835459046 0.572361176931318 1.05166112956811 0.357142857142857 4.2 4 2 corneal vascularization 0.148467835459046 0.572361176931318 1.05166112956811 0.357142857142857 4.2 4 2 abnormal kidney blood vessel morphology 0.268804155379052 0.647412929138196 1.05166112956811 0.357142857142857 4.2 4 2 abnormal fluid regulation 0.268804155379052 0.647412929138196 1.05166112956811 0.357142857142857 4.2 4 2 absent otoliths 0.268804155379052 0.647412929138196 1.05166112956811 0.357142857142857 4.2 4 2 abnormal vascular endothelial cell migration 0.268804155379052 0.647412929138196 1.05166112956811 0.357142857142857 4.2 4 2 split sternum 0.268804155379052 0.647412929138196 1.05166112956811 0.357142857142857 4.2 4 2 decreased CNS synapse formation 0.268804155379052 0.647412929138196 1.05166112956811 0.357142857142857 4.2 4 2 irregular heartbeat 0.0835127501770747 0.382574523140835 1.04698708010336 0.355555555555556 4.2 4 2 increased circulating corticosterone level 0.0835127501770747 0.382574523140835 1.04698708010336 0.355555555555556 4.2 4 2 albuminuria 0.0835127501770747 0.382574523140835 1.04698708010336 0.355555555555556 4.2 4 2 decreased osteoclast cell number 0.0835127501770747 0.382574523140835 1.04698708010336 0.355555555555556 4.2 4 2 abnormal metabolism 0.0835127501770747 0.382574523140835 1.04698708010336 0.355555555555556 4.2 4 2 cataract 0.00810791958252078 0.0749756504145741 1.04644628099174 0.355371900826446 4.2 4 2 abnormal bone mineralization 0.00810791958252078 0.0749756504145741 1.04644628099174 0.355371900826446 4.2 4 2 absent mature ovarian follicles 0.13845192279284 0.541934158846874 1.04487621905476 0.354838709677419 4.2 4 2 abnormal capillary morphology 0.13845192279284 0.541934158846874 1.04487621905476 0.354838709677419 4.2 4 2 decreased susceptibility to bacterial infection induced morbidity/mortality 0.13845192279284 0.541934158846874 1.04487621905476 0.354838709677419 4.2 4 2 abnormal intestine physiology 0.13845192279284 0.541934158846874 1.04487621905476 0.354838709677419 4.2 4 2 abnormal myocardium layer morphology 0.0295379627653807 0.196459043793808 1.04367382984987 0.354430379746835 4.2 4 2 curly tail 0.0785040126821211 0.373381895882937 1.04289728682171 0.354166666666667 4.2 4 2 decreased susceptibility to injury 0.0437125884515179 0.260755548616669 1.03928864569083 0.352941176470588 4.2 4 2 distended abdomen 0.0738214637543439 0.352661934307144 1.03928864569083 0.352941176470588 4.2 4 2 abnormal gluconeogenesis 0.0738214637543439 0.352661934307144 1.03928864569083 0.352941176470588 4.2 4 2 abnormal glutamate-mediated receptor currents 0.245493388020994 0.641832829137905 1.03928864569083 0.352941176470588 4.2 4 2 increased brain size 0.245493388020994 0.641832829137905 1.03928864569083 0.352941176470588 4.2 4 2 increased circulating magnesium level 0.245493388020994 0.641832829137905 1.03928864569083 0.352941176470588 4.2 4 2 increased trabecular bone mass 0.245493388020994 0.641832829137905 1.03928864569083 0.352941176470588 4.2 4 2 abnormal electroretinogram waveform feature 0.245493388020994 0.641832829137905 1.03928864569083 0.352941176470588 4.2 4 2 increased circulating cholesterol level 0.00222439552302197 0.0271227134430318 1.03732029598309 0.352272727272727 4.2 4 2 abnormal axon morphology 0.0145377259489535 0.118955899006651 1.03608096468562 0.351851851851852 4.2 4 2 abnormal osteoblast physiology 0.069441950703666 0.340033173967262 1.03608096468562 0.351851851851852 4.2 4 2 malocclusion 0.120786784796544 0.480347125789614 1.03460716530484 0.351351351351351 4.2 4 2 abnormal vocalization 0.120786784796544 0.480347125789614 1.03460716530484 0.351351351351351 4.2 4 2 abnormal pancreatic beta cell physiology 0.120786784796544 0.480347125789614 1.03460716530484 0.351351351351351 4.2 4 2 increased total body fat amount 0.00768892033212603 0.0717680650137467 1.0328254078445 0.350746268656716 4.2 4 2 decreased startle reflex 0.0123627486161495 0.10549686855119 1.03188630490956 0.35042735042735 4.2 4 2 abnormal enzyme/coenzyme activity 0.00433265406339221 0.0448127941068114 1.03156569397126 0.35031847133758 4.2 4 2 increased circulating insulin level 0.0041118306819259 0.043235336114652 1.03062790697674 0.35 4.2 4 2 abnormal retinal pigment epithelium morphology 0.0347343289617138 0.222971982689711 1.03062790697674 0.35 4.2 4 2 perinatal lethality 0.112975956638578 0.472315448972208 1.03062790697674 0.35 4.2 4 2 waved hair 0.225329738535496 0.641832829137905 1.03062790697674 0.35 4.2 4 2 abnormal hyoid bone morphology 0.225329738535496 0.641832829137905 1.03062790697674 0.35 4.2 4 2 abnormal response to tactile stimuli 0.225329738535496 0.641832829137905 1.03062790697674 0.35 4.2 4 2 abnormal neuron proliferation 0.225329738535496 0.641832829137905 1.03062790697674 0.35 4.2 4 2 decreased muscle cell glucose uptake 0.225329738535496 0.641832829137905 1.03062790697674 0.35 4.2 4 2 abnormal eating behavior 0.0615074440171181 0.315593996440641 1.03062790697674 0.35 4.2 4 2 postnatal lethality 0.00370336446394552 0.0407615889560375 1.0288540207341 0.349397590361446 4.2 4 2 abnormal lipid level 0.0328057783718693 0.21141029455965 1.0288540207341 0.349397590361446 4.2 4 2 reduced male fertility 0.000929278930763369 0.0135272524468207 1.02479049277738 0.348017621145374 4.2 4 2 abnormal sternum morphology 0.0513896774099663 0.290072777029703 1.02422649140546 0.347826086956522 4.2 4 2 abnormal blood vessel physiology 0.207612902565571 0.641832829137905 1.02422649140546 0.347826086956522 4.2 4 2 abnormal innervation pattern to muscle 0.207612902565571 0.641832829137905 1.02422649140546 0.347826086956522 4.2 4 2 abnormal cranial nerve morphology 0.207612902565571 0.641832829137905 1.02422649140546 0.347826086956522 4.2 4 2 abnormal circulating insulin level 0.207612902565571 0.641832829137905 1.02422649140546 0.347826086956522 4.2 4 2 failure of embryo implantation 0.207612902565571 0.641832829137905 1.02422649140546 0.347826086956522 4.2 4 2 abnormal nasal cavity morphology 0.207612902565571 0.641832829137905 1.02422649140546 0.347826086956522 4.2 4 2 abnormal regulatory T cell physiology 0.207612902565571 0.641832829137905 1.02422649140546 0.347826086956522 4.2 4 2 abnormal palatal shelf fusion at midline 0.207612902565571 0.641832829137905 1.02422649140546 0.347826086956522 4.2 4 2 decreased birth weight 0.0261403847155497 0.181691200768381 1.0228788249694 0.347368421052632 4.2 4 2 cardiac hypertrophy 0.0247056231915414 0.17335751111131 1.0216136687233 0.346938775510204 4.2 4 2 organ of Corti degeneration 0.0928741034855897 0.415885386895417 1.0216136687233 0.346938775510204 4.2 4 2 abnormal craniofacial development 0.0928741034855897 0.415885386895417 1.0216136687233 0.346938775510204 4.2 4 2 ventricular hypoplasia 0.191867991221956 0.635938212078103 1.0193023255814 0.346153846153846 4.2 4 2 abnormal stomach morphology 0.191867991221956 0.635938212078103 1.0193023255814 0.346153846153846 4.2 4 2 abnormal nerve conduction 0.191867991221956 0.635938212078103 1.0193023255814 0.346153846153846 4.2 4 2 decreased bone mineral density 0.000476036193373328 0.00779731983726294 1.01845077810806 0.345864661654135 4.2 4 2 abnormal rostral-caudal axis patterning 0.0817661211267526 0.380340764722492 1.01724312896406 0.345454545454545 4.2 4 2 abnormal microglial cell morphology 0.177754462842893 0.59711576815894 1.01539695268645 0.344827586206897 4.2 4 2 lordosis 0.177754462842893 0.59711576815894 1.01539695268645 0.344827586206897 4.2 4 2 decreased retinal photoreceptor cell number 0.177754462842893 0.59711576815894 1.01539695268645 0.344827586206897 4.2 4 2 increased circulating triglyceride level 0.00881352445355307 0.079867548554511 1.01539695268645 0.344827586206897 4.2 4 2 decreased insulin secretion 0.0340920181019834 0.219131511702025 1.01426873385013 0.344444444444444 4.2 4 2 respiratory failure 0.00790838570839053 0.0735405960733512 1.01405205606037 0.344370860927152 4.2 4 2 increased body weight 0.00157895228193003 0.0204033444223426 1.0122238372093 0.34375 4.2 4 2 abnormal lymphatic vessel morphology 0.165017620540748 0.585983342034419 1.0122238372093 0.34375 4.2 4 2 neonatal lethality 0.165017620540748 0.585983342034419 1.0122238372093 0.34375 4.2 4 2 bradykinesia 0.165017620540748 0.585983342034419 1.0122238372093 0.34375 4.2 4 2 kinked tail 0.0270899859517657 0.187705682604505 1.01041951664387 0.343137254901961 4.2 4 2 impaired balance 0.0270899859517657 0.187705682604505 1.01041951664387 0.343137254901961 4.2 4 2 decreased triglyceride level 0.153460636515562 0.575886594360896 1.00959468438538 0.342857142857143 4.2 4 2 decreased circulating thyroxine level 0.153460636515562 0.575886594360896 1.00959468438538 0.342857142857143 4.2 4 2 abnormal frontal bone morphology 0.142927384567068 0.557259982931948 1.00738066095471 0.342105263157895 4.2 4 2 abnormal compact bone morphology 0.142927384567068 0.557259982931948 1.00738066095471 0.342105263157895 4.2 4 2 ataxia 0.00317529371196498 0.0356593368330153 1.00584618927009 0.341584158415842 4.2 4 2 increased tumor growth/size 0.133291369304325 0.525455279151361 1.00549064095292 0.341463414634146 4.2 4 2 small kidney 0.0418805382948745 0.252552336990304 1.00385835095137 0.340909090909091 4.2 4 2 abnormal gametogenesis 0.124448290704775 0.492938094153069 1.00385835095137 0.340909090909091 4.2 4 2 renal interstitial fibrosis 0.124448290704775 0.492938094153069 1.00385835095137 0.340909090909091 4.2 4 2 increased circulating chloride level 0.108805194612473 0.45602851153922 1.00118139534884 0.34 4.2 4 2 microphthalmia 0.0104640143998212 0.0926307324539331 1.00079647362821 0.339869281045752 4.2 4 2 abnormal mesoderm development 0.101867931611764 0.452090062237756 1.0000702062308 0.339622641509434 4.2 4 2 infertility 0.0339076136023234 0.218228172925691 0.990723755705281 0.336448598130841 4.2 4 2 postnatal lethality, incomplete penetrance 5.5104981485035e-06 0.000176869214766483 0.990190795938421 0.336267605633803 4.2 4 2 abnormal glucose homeostasis 0.00831980898444584 0.0758077833289708 0.986943521594684 0.335164835164835 4.2 4 2 abnormal urine homeostasis 0.0491233820114104 0.289217544978422 0.981550387596899 0.333333333333333 4.2 4 2 increased food intake 0.0625373559115694 0.315593996440641 0.981550387596899 0.333333333333333 4.2 4 2 hyperkeratosis 0.0853297144475001 0.384873372054681 0.981550387596899 0.333333333333333 4.2 4 2 abnormal hair follicle morphology 0.0969734049069187 0.432684026378404 0.981550387596899 0.333333333333333 4.2 4 2 skin edema 0.155500862014978 0.575886594360896 0.981550387596899 0.333333333333333 4.2 4 2 dilated heart atrium 0.193866127568003 0.641705911277988 0.981550387596899 0.333333333333333 4.2 4 2 blindness 0.246503165966682 0.641832829137905 0.981550387596899 0.333333333333333 4.2 4 2 hypopigmentation 0.246503165966682 0.641832829137905 0.981550387596899 0.333333333333333 4.2 4 2 abnormal truncus arteriosus septation 0.246503165966682 0.641832829137905 0.981550387596899 0.333333333333333 4.2 4 2 abnormal lung saccule morphology 0.246503165966682 0.641832829137905 0.981550387596899 0.333333333333333 4.2 4 2 abnormal scapula morphology 0.268855298813973 0.647412929138196 0.981550387596899 0.333333333333333 4.2 4 2 dry skin 0.268855298813973 0.647412929138196 0.981550387596899 0.333333333333333 4.2 4 2 abnormal embryonic/fetal subventricular zone morphology 0.268855298813973 0.647412929138196 0.981550387596899 0.333333333333333 4.2 4 2 increased bone ossification 0.268855298813973 0.647412929138196 0.981550387596899 0.333333333333333 4.2 4 2 cortical renal glomerulopathies 0.294682732803108 0.698144212600898 0.981550387596899 0.333333333333333 4.2 4 2 abnormal radius morphology 0.294682732803108 0.698144212600898 0.981550387596899 0.333333333333333 4.2 4 2 abnormal mammary gland morphology 0.294682732803108 0.698144212600898 0.981550387596899 0.333333333333333 4.2 4 2 abnormal retinal rod cell morphology 0.294682732803108 0.698144212600898 0.981550387596899 0.333333333333333 4.2 4 2 abnormal thyroid cartilage morphology 0.294682732803108 0.698144212600898 0.981550387596899 0.333333333333333 4.2 4 2 abnormal white adipose tissue morphology 0.294682732803108 0.698144212600898 0.981550387596899 0.333333333333333 4.2 4 2 increased circulating renin level 0.294682732803108 0.698144212600898 0.981550387596899 0.333333333333333 4.2 4 2 abnormal body wall morphology 0.294682732803108 0.698144212600898 0.981550387596899 0.333333333333333 4.2 4 2 increased circulating glycerol level 0.294682732803108 0.698144212600898 0.981550387596899 0.333333333333333 4.2 4 2 jerky movement 0.294682732803108 0.698144212600898 0.981550387596899 0.333333333333333 4.2 4 2 abnormal pregnancy 0.294682732803108 0.698144212600898 0.981550387596899 0.333333333333333 4.2 4 2 abnormal sperm axoneme morphology 0.294682732803108 0.698144212600898 0.981550387596899 0.333333333333333 4.2 4 2 muscular ventricular septal defect 0.10347659226363 0.454013620126724 0.981550387596899 0.333333333333333 4.2 4 2 abnormal maxilla morphology 0.118080922065812 0.47739976059354 0.981550387596899 0.333333333333333 4.2 4 2 abnormal mandible morphology 0.118080922065812 0.47739976059354 0.981550387596899 0.333333333333333 4.2 4 2 abnormal neuronal precursor proliferation 0.118080922065812 0.47739976059354 0.981550387596899 0.333333333333333 4.2 4 2 abnormal dendritic spine morphology 0.126297060041538 0.499863065796859 0.981550387596899 0.333333333333333 4.2 4 2 small lens 0.16708659176926 0.58947006189941 0.981550387596899 0.333333333333333 4.2 4 2 abnormal trigeminal nerve morphology 0.226877512173275 0.641832829137905 0.981550387596899 0.333333333333333 4.2 4 2 emphysema 0.20945802542218 0.641832829137905 0.981550387596899 0.333333333333333 4.2 4 2 abnormal palate morphology 0.226877512173275 0.641832829137905 0.981550387596899 0.333333333333333 4.2 4 2 abnormal skin appearance 0.226877512173275 0.641832829137905 0.981550387596899 0.333333333333333 4.2 4 2 thick interventricular septum 0.226877512173275 0.641832829137905 0.981550387596899 0.333333333333333 4.2 4 2 abnormal fontanelle morphology 0.325130433761755 0.749789529705582 0.981550387596899 0.333333333333333 4.2 4 2 absent incisors 0.325130433761755 0.749789529705582 0.981550387596899 0.333333333333333 4.2 4 2 abnormal epidermis stratum spinosum morphology 0.325130433761755 0.749789529705582 0.981550387596899 0.333333333333333 4.2 4 2 placental labyrinth hypoplasia 0.325130433761755 0.749789529705582 0.981550387596899 0.333333333333333 4.2 4 2 abnormal respiratory system morphology 0.325130433761755 0.749789529705582 0.981550387596899 0.333333333333333 4.2 4 2 abnormal pericyte morphology 0.325130433761755 0.749789529705582 0.981550387596899 0.333333333333333 4.2 4 2 decreased aggression towards males 0.325130433761755 0.749789529705582 0.981550387596899 0.333333333333333 4.2 4 2 abnormal neurotransmitter secretion 0.325130433761755 0.749789529705582 0.981550387596899 0.333333333333333 4.2 4 2 herniated liver 0.325130433761755 0.749789529705582 0.981550387596899 0.333333333333333 4.2 4 2 abnormal branching involved in lung morphogenesis 0.325130433761755 0.749789529705582 0.981550387596899 0.333333333333333 4.2 4 2 hyperactivity 0.000440621977105413 0.00750717238390215 0.976259010844355 0.331536388140162 4.2 4 2 hydroencephaly 0.0392616085289878 0.243589828690197 0.973015166835187 0.330434782608696 4.2 4 2 abnormal gait 0.00149762906118424 0.0196588511329593 0.972020772183337 0.330097087378641 4.2 4 2 impaired coordination 0.000893462917841656 0.0130734647537125 0.97020298427208 0.329479768786127 4.2 4 2 hunched posture 0.0808563702031451 0.379849331218741 0.969125699146306 0.329113924050633 4.2 4 2 thick epidermis 0.0977308707513866 0.43528297402699 0.967528239202658 0.328571428571429 4.2 4 2 abnormal enzyme/coenzyme level 0.126917757977679 0.501920386278976 0.964627105052125 0.327586206896552 4.2 4 2 abnormal contextual conditioning behavior 0.135747581982112 0.533868948901982 0.963704016913319 0.327272727272727 4.2 4 2 increased susceptibility to injury 0.145326825098202 0.565286125772911 0.962674418604651 0.326923076923077 4.2 4 2 increased circulating LDL cholesterol level 0.155742895648122 0.575886594360896 0.961518747033697 0.326530612244898 4.2 4 2 increased fluid intake 0.155742895648122 0.575886594360896 0.961518747033697 0.326530612244898 4.2 4 2 delayed wound healing 0.167098448333357 0.58947006189941 0.960212335692619 0.326086956521739 4.2 4 2 kidney failure 0.179515317620095 0.602623957597822 0.958723634396971 0.325581395348837 4.2 4 2 abnormal female reproductive system morphology 0.193139860535885 0.639727567354213 0.957011627906977 0.325 4.2 4 2 abnormal intestine morphology 0.104329139727761 0.454013620126724 0.955021998742929 0.324324324324324 4.2 4 2 increased brown adipose tissue amount 0.20815037404011 0.641832829137905 0.955021998742929 0.324324324324324 4.2 4 2 decreased width of hypertrophic chondrocyte zone 0.20815037404011 0.641832829137905 0.955021998742929 0.324324324324324 4.2 4 2 abnormal hair follicle development 0.20815037404011 0.641832829137905 0.955021998742929 0.324324324324324 4.2 4 2 atelectasis 0.11123400304529 0.465424024516666 0.953901080904029 0.323943661971831 4.2 4 2 lethargy 0.0811261204998376 0.380340764722492 0.949887471867967 0.32258064516129 4.2 4 2 abnormal object recognition memory 0.243270455245675 0.641832829137905 0.949887471867967 0.32258064516129 4.2 4 2 decreased neuronal precursor cell number 0.243270455245675 0.641832829137905 0.949887471867967 0.32258064516129 4.2 4 2 small cranium 0.243270455245675 0.641832829137905 0.949887471867967 0.32258064516129 4.2 4 2 abnormal colon morphology 0.144697426830883 0.563278324322099 0.948277493102089 0.322033898305085 4.2 4 2 decreased exploration in new environment 0.0976444123215154 0.43528297402699 0.946495016611296 0.321428571428571 4.2 4 2 rib bifurcation 0.264018937985278 0.647412929138196 0.946495016611296 0.321428571428571 4.2 4 2 shortened head 0.264018937985278 0.647412929138196 0.946495016611296 0.321428571428571 4.2 4 2 increased triglyceride level 0.264018937985278 0.647412929138196 0.946495016611296 0.321428571428571 4.2 4 2 prolonged QRS complex duration 0.264018937985278 0.647412929138196 0.946495016611296 0.321428571428571 4.2 4 2 abnormal heart ventricle morphology 0.110733579374767 0.46372016615275 0.943798449612403 0.320512820512821 4.2 4 2 neonatal lethality, complete penetrance 0.000765847651763215 0.0115808269529544 0.94280497756018 0.320175438596491 4.2 4 2 decreased heart rate 0.0808145220479403 0.379849331218741 0.942288372093023 0.32 4.2 4 2 abnormal inner ear vestibule morphology 0.287491600580127 0.68829196962759 0.942288372093023 0.32 4.2 4 2 abnormal thyroid gland morphology 0.287491600580127 0.68829196962759 0.942288372093023 0.32 4.2 4 2 abnormal primitive streak morphology 0.287491600580127 0.68829196962759 0.942288372093023 0.32 4.2 4 2 decreased placenta weight 0.287491600580127 0.68829196962759 0.942288372093023 0.32 4.2 4 2 abnormal trabecular bone morphology 0.0633526146668716 0.315593996440641 0.94030877467266 0.319327731092437 4.2 4 2 abnormal skin morphology 0.14336467919319 0.558527234914738 0.936934460887949 0.318181818181818 4.2 4 2 hyperglycemia 0.103224696672699 0.454013620126724 0.936934460887949 0.318181818181818 4.2 4 2 increased liver weight 0.103224696672699 0.454013620126724 0.936934460887949 0.318181818181818 4.2 4 2 abnormal astrocyte morphology 0.205213263513911 0.641832829137905 0.936934460887949 0.318181818181818 4.2 4 2 abnormal basisphenoid bone morphology 0.314346397032642 0.733868289646829 0.936934460887949 0.318181818181818 4.2 4 2 abnormal facial nerve morphology 0.314346397032642 0.733868289646829 0.936934460887949 0.318181818181818 4.2 4 2 decreased airway responsiveness 0.314346397032642 0.733868289646829 0.936934460887949 0.318181818181818 4.2 4 2 abnormal chorion morphology 0.314346397032642 0.733868289646829 0.936934460887949 0.318181818181818 4.2 4 2 abnormal female reproductive system physiology 0.314346397032642 0.733868289646829 0.936934460887949 0.318181818181818 4.2 4 2 decreased cardiac muscle contractility 0.085241102681782 0.384822582433635 0.934360465116279 0.317307692307692 4.2 4 2 abnormal response/metabolism to endogenous compounds 0.116946894573472 0.47739976059354 0.933669880884855 0.317073170731707 4.2 4 2 short humerus 0.220926660036252 0.641832829137905 0.933669880884855 0.317073170731707 4.2 4 2 lethality at weaning, incomplete penetrance 0.220926660036252 0.641832829137905 0.933669880884855 0.317073170731707 4.2 4 2 abnormal eye physiology 0.163799764801073 0.585983342034419 0.932472868217054 0.316666666666667 4.2 4 2 abnormal facial morphology 0.175305021245835 0.590082869213823 0.929889840881273 0.315789473684211 4.2 4 2 abnormal reproductive system physiology 0.238253292258437 0.641832829137905 0.929889840881273 0.315789473684211 4.2 4 2 hyporesponsive to tactile stimuli 0.238253292258437 0.641832829137905 0.929889840881273 0.315789473684211 4.2 4 2 kyphoscoliosis 0.345527948563076 0.779239140571761 0.929889840881273 0.315789473684211 4.2 4 2 short vibrissae 0.345527948563076 0.779239140571761 0.929889840881273 0.315789473684211 4.2 4 2 stereotypic behavior 0.345527948563076 0.779239140571761 0.929889840881273 0.315789473684211 4.2 4 2 unresponsive to tactile stimuli 0.345527948563076 0.779239140571761 0.929889840881273 0.315789473684211 4.2 4 2 abnormal long term depression 0.345527948563076 0.779239140571761 0.929889840881273 0.315789473684211 4.2 4 2 eyelids fail to open 0.345527948563076 0.779239140571761 0.929889840881273 0.315789473684211 4.2 4 2 decreased liver glycogen level 0.345527948563076 0.779239140571761 0.929889840881273 0.315789473684211 4.2 4 2 thin interventricular septum 0.345527948563076 0.779239140571761 0.929889840881273 0.315789473684211 4.2 4 2 abnormal fertility/fecundity 0.141549005565874 0.553186412168282 0.927766804714877 0.315068493150685 4.2 4 2 impaired limb coordination 0.187796612542926 0.62369035207013 0.927019810508183 0.314814814814815 4.2 4 2 increased insulin sensitivity 0.0584238131827986 0.312948203498614 0.926638477801268 0.314685314685315 4.2 4 2 impaired fertilization 0.151022435297643 0.575886594360896 0.925461794019933 0.314285714285714 4.2 4 2 abnormal cervical vertebrae morphology 0.201389701207006 0.641832829137905 0.923812129502964 0.313725490196078 4.2 4 2 abnormal posture 0.139399727468281 0.545215129052435 0.920203488372093 0.3125 4.2 4 2 abnormal hair shaft morphology 0.216219127236968 0.641832829137905 0.920203488372093 0.3125 4.2 4 2 abnormal vertebral body morphology 0.278839925566096 0.669511886916665 0.920203488372093 0.3125 4.2 4 2 abnormal depression-related behavior 0.278839925566096 0.669511886916665 0.920203488372093 0.3125 4.2 4 2 pancreatic islet hyperplasia 0.278839925566096 0.669511886916665 0.920203488372093 0.3125 4.2 4 2 abnormal auditory brainstem response waveform shape 0.278839925566096 0.669511886916665 0.920203488372093 0.3125 4.2 4 2 abnormal tympanic ring morphology 0.38247013484593 0.821584162719559 0.920203488372093 0.3125 4.2 4 2 vasculature congestion 0.38247013484593 0.821584162719559 0.920203488372093 0.3125 4.2 4 2 disorganized retinal layers 0.38247013484593 0.821584162719559 0.920203488372093 0.3125 4.2 4 2 white spotting 0.38247013484593 0.821584162719559 0.920203488372093 0.3125 4.2 4 2 small pancreas 0.38247013484593 0.821584162719559 0.920203488372093 0.3125 4.2 4 2 abnormal wound healing 0.38247013484593 0.821584162719559 0.920203488372093 0.3125 4.2 4 2 dystonia 0.38247013484593 0.821584162719559 0.920203488372093 0.3125 4.2 4 2 abnormal thoracic cage shape 0.38247013484593 0.821584162719559 0.920203488372093 0.3125 4.2 4 2 decreased adipocyte glucose uptake 0.38247013484593 0.821584162719559 0.920203488372093 0.3125 4.2 4 2 polyuria 0.148526287320268 0.572361176931318 0.917813349441256 0.311688311688312 4.2 4 2 altered response to myocardial infarction 0.232444258211782 0.641832829137905 0.916113695090439 0.311111111111111 4.2 4 2 abnormal ectoderm development 0.232444258211782 0.641832829137905 0.916113695090439 0.311111111111111 4.2 4 2 postnatal lethality, complete penetrance 0.00619009538231811 0.0592225471673703 0.915435594649958 0.310880829015544 4.2 4 2 kidney cysts 0.158334435257572 0.575886594360896 0.915229415461974 0.310810810810811 4.2 4 2 abnormal circulating glucose level 0.302837951799352 0.710334186799517 0.913857257417803 0.310344827586207 4.2 4 2 stomach inflammation 0.302837951799352 0.710334186799517 0.913857257417803 0.310344827586207 4.2 4 2 decreased bone strength 0.302837951799352 0.710334186799517 0.913857257417803 0.310344827586207 4.2 4 2 increased retinal apoptosis 0.302837951799352 0.710334186799517 0.913857257417803 0.310344827586207 4.2 4 2 decreased liver weight 0.168886629370129 0.58947006189941 0.912427120864723 0.309859154929577 4.2 4 2 hydronephrosis 0.145805954929023 0.56670673888429 0.911439645625692 0.30952380952381 4.2 4 2 spina bifida 0.250255466045788 0.641832829137905 0.911439645625692 0.30952380952381 4.2 4 2 increased exploration in new environment 0.155222031695698 0.575886594360896 0.90884295147861 0.308641975308642 4.2 4 2 abnormal skeleton development 0.155222031695698 0.575886594360896 0.90884295147861 0.308641975308642 4.2 4 2 cleft secondary palate 0.134486333575661 0.529327143622558 0.90845620979713 0.308510638297872 4.2 4 2 abnormal snout morphology 0.226306535033141 0.641832829137905 0.906046511627907 0.307692307692308 4.2 4 2 absent corpus luteum 0.226306535033141 0.641832829137905 0.906046511627907 0.307692307692308 4.2 4 2 no spontaneous movement 0.329990982517091 0.749789529705582 0.906046511627907 0.307692307692308 4.2 4 2 increased susceptibility to otitis media 0.329990982517091 0.749789529705582 0.906046511627907 0.307692307692308 4.2 4 2 absent gastric milk in neonates 0.165323046407157 0.586649183934098 0.906046511627907 0.307692307692308 4.2 4 2 abnormal heart looping 0.269882936920294 0.649573106520784 0.906046511627907 0.307692307692308 4.2 4 2 abnormal long bone hypertrophic chondrocyte zone 0.242899817643812 0.641832829137905 0.901423825344091 0.306122448979592 4.2 4 2 decreased urine osmolality 0.242899817643812 0.641832829137905 0.901423825344091 0.306122448979592 4.2 4 2 circling 0.161652254526107 0.580664235572118 0.90071682626539 0.305882352941176 4.2 4 2 heart right ventricle hypertrophy 0.291608906264783 0.696139303583156 0.899754521963824 0.305555555555556 4.2 4 2 narrow eye opening 0.291608906264783 0.696139303583156 0.899754521963824 0.305555555555556 4.2 4 2 increased circulating glucose level 0.0966863412734415 0.43179043791326 0.898014184397163 0.304964539007092 4.2 4 2 abnormal inner ear morphology 0.261033050033593 0.647412929138196 0.896198179979778 0.304347826086957 4.2 4 2 abnormal sleep pattern 0.261033050033593 0.647412929138196 0.896198179979778 0.304347826086957 4.2 4 2 fragile skeleton 0.361042300861985 0.807462762182242 0.896198179979778 0.304347826086957 4.2 4 2 abnormal pulmonary artery morphology 0.361042300861985 0.807462762182242 0.896198179979778 0.304347826086957 4.2 4 2 bidirectional circling 0.361042300861985 0.807462762182242 0.896198179979778 0.304347826086957 4.2 4 2 hypotension 0.361042300861985 0.807462762182242 0.896198179979778 0.304347826086957 4.2 4 2 abnormal corneal stroma morphology 0.361042300861985 0.807462762182242 0.896198179979778 0.304347826086957 4.2 4 2 abnormal neuron differentiation 0.133957418630371 0.527662832688913 0.89391196013289 0.303571428571429 4.2 4 2 abnormal seminal vesicle morphology 0.235597942201065 0.641832829137905 0.89391196013289 0.303571428571429 4.2 4 2 abnormal aorta morphology 0.315785055130485 0.736190557298107 0.892318534178999 0.303030303030303 4.2 4 2 abnormal epidermis stratum basale morphology 0.315785055130485 0.736190557298107 0.892318534178999 0.303030303030303 4.2 4 2 abnormal locomotor coordination 0.315785055130485 0.736190557298107 0.892318534178999 0.303030303030303 4.2 4 2 abnormal vertebrae morphology 0.141972753993771 0.55440694750315 0.891499893321954 0.302752293577982 4.2 4 2 hypoactivity 0.0177014149468872 0.130866328879306 0.890425020048115 0.302387267904509 4.2 4 2 delayed endochondral bone ossification 0.280909530363589 0.67415577113307 0.890243374797188 0.302325581395349 4.2 4 2 abnormal pancreatic islet morphology 0.252450299217986 0.641832829137905 0.88895129442738 0.30188679245283 4.2 4 2 decreased circulating phosphate level 0.302772826799326 0.710334186799517 0.883395348837209 0.3 4.2 4 2 abnormal skin pigmentation 0.302772826799326 0.710334186799517 0.883395348837209 0.3 4.2 4 2 increased susceptibility to weight loss 0.302772826799326 0.710334186799517 0.883395348837209 0.3 4.2 4 2 increased urine glucose level 0.397041467146325 0.836259035731814 0.883395348837209 0.3 4.2 4 2 kidney atrophy 0.397041467146325 0.836259035731814 0.883395348837209 0.3 4.2 4 2 nuclear cataracts 0.397041467146325 0.836259035731814 0.883395348837209 0.3 4.2 4 2 abnormal long bone epiphyseal plate morphology 0.244194679556263 0.641832829137905 0.883395348837209 0.3 4.2 4 2 short stride length 0.270786357113766 0.6514323629792 0.883395348837209 0.3 4.2 4 2 abnormal heart tube morphology 0.342857920246711 0.776031916845945 0.883395348837209 0.3 4.2 4 2 abnormal hair cycle 0.342857920246711 0.776031916845945 0.883395348837209 0.3 4.2 4 2 abnormal response to new environment 0.342857920246711 0.776031916845945 0.883395348837209 0.3 4.2 4 2 rib fusion 0.236282796473242 0.641832829137905 0.879000347101701 0.298507462686567 4.2 4 2 abnormal craniofacial bone morphology 0.261222433607038 0.647412929138196 0.878229294165647 0.298245614035088 4.2 4 2 pulmonary hypoplasia 0.290784292233173 0.694837585907799 0.877130133597229 0.297872340425532 4.2 4 2 increased systemic arterial blood pressure 0.290784292233173 0.694837585907799 0.877130133597229 0.297872340425532 4.2 4 2 thin epidermis 0.373407180556593 0.808490306080356 0.872489233419466 0.296296296296296 4.2 4 2 cryptorchism 0.373407180556593 0.808490306080356 0.872489233419466 0.296296296296296 4.2 4 2 abnormal motor capabilities/coordination/movement 0.156276608426092 0.575886594360896 0.870010570824524 0.295454545454545 4.2 4 2 abnormal circadian rhythm 0.31265312613926 0.73197614237309 0.870010570824524 0.295454545454545 4.2 4 2 omphalocele 0.31265312613926 0.73197614237309 0.870010570824524 0.295454545454545 4.2 4 2 increased circulating alanine transaminase level 0.235505288483331 0.641832829137905 0.868294573643411 0.294871794871795 4.2 4 2 respiratory distress 0.123091982934951 0.488343393222793 0.868076354348703 0.294797687861272 4.2 4 2 abnormal thrombosis 0.299701630408249 0.705639191330355 0.866073871409029 0.294117647058824 4.2 4 2 short maxilla 0.353708972815838 0.794447918626994 0.866073871409029 0.294117647058824 4.2 4 2 abnormal retinal photoreceptor morphology 0.353708972815838 0.794447918626994 0.866073871409029 0.294117647058824 4.2 4 2 overexpanded pulmonary alveoli 0.353708972815838 0.794447918626994 0.866073871409029 0.294117647058824 4.2 4 2 abnormal endoderm development 0.353708972815838 0.794447918626994 0.866073871409029 0.294117647058824 4.2 4 2 abnormal vision 0.353708972815838 0.794447918626994 0.866073871409029 0.294117647058824 4.2 4 2 increased width of hypertrophic chondrocyte zone 0.353708972815838 0.794447918626994 0.866073871409029 0.294117647058824 4.2 4 2 decreased osteoblast cell number 0.353708972815838 0.794447918626994 0.866073871409029 0.294117647058824 4.2 4 2 abnormal skin physiology 0.353708972815838 0.794447918626994 0.866073871409029 0.294117647058824 4.2 4 2 abnormal bone marrow cavity morphology 0.43954377935632 0.836259035731814 0.866073871409029 0.294117647058824 4.2 4 2 distended urinary bladder 0.43954377935632 0.836259035731814 0.866073871409029 0.294117647058824 4.2 4 2 abnormal vagus nerve morphology 0.43954377935632 0.836259035731814 0.866073871409029 0.294117647058824 4.2 4 2 abnormal heart rate 0.43954377935632 0.836259035731814 0.866073871409029 0.294117647058824 4.2 4 2 decreased vasoconstriction 0.43954377935632 0.836259035731814 0.866073871409029 0.294117647058824 4.2 4 2 aminoaciduria 0.43954377935632 0.836259035731814 0.866073871409029 0.294117647058824 4.2 4 2 abnormal testis development 0.43954377935632 0.836259035731814 0.866073871409029 0.294117647058824 4.2 4 2 abnormal tarsal bone morphology 0.43954377935632 0.836259035731814 0.866073871409029 0.294117647058824 4.2 4 2 abnormal ductus venosus valve morphology 0.43954377935632 0.836259035731814 0.866073871409029 0.294117647058824 4.2 4 2 palatal shelves fail to meet at midline 0.336640206149563 0.763132950570078 0.86184912081679 0.292682926829268 4.2 4 2 abnormal heart left ventricle morphology 0.266596837902283 0.647412929138196 0.858856589147287 0.291666666666667 4.2 4 2 curly vibrissae 0.408205474054169 0.836259035731814 0.858856589147287 0.291666666666667 4.2 4 2 abnormal nursing 0.408205474054169 0.836259035731814 0.858856589147287 0.291666666666667 4.2 4 2 abnormal impulse conducting system conduction 0.408205474054169 0.836259035731814 0.858856589147287 0.291666666666667 4.2 4 2 prolonged QT interval 0.408205474054169 0.836259035731814 0.858856589147287 0.291666666666667 4.2 4 2 decreased fatty acid level 0.408205474054169 0.836259035731814 0.858856589147287 0.291666666666667 4.2 4 2 abnormal blood homeostasis 0.216710086693047 0.641832829137905 0.852399020807834 0.289473684210526 4.2 4 2 abnormal hair growth 0.329456398803564 0.749789529705582 0.849418604651163 0.288461538461538 4.2 4 2 abnormal tail morphology 0.302273979343262 0.710334186799517 0.847702607470049 0.287878787878788 4.2 4 2 improved glucose tolerance 0.168911677622535 0.58947006189941 0.841328903654485 0.285714285714286 4.2 4 2 reduced long term potentiation 0.246514643691059 0.641832829137905 0.841328903654485 0.285714285714286 4.2 4 2 short mandible 0.336698859598256 0.763132950570078 0.841328903654485 0.285714285714286 4.2 4 2 abnormal eye development 0.336698859598256 0.763132950570078 0.841328903654485 0.285714285714286 4.2 4 2 abnormal stria vascularis morphology 0.417162477585119 0.836259035731814 0.841328903654485 0.285714285714286 4.2 4 2 abnormal jaw morphology 0.417162477585119 0.836259035731814 0.841328903654485 0.285714285714286 4.2 4 2 abnormal respiration 0.417162477585119 0.836259035731814 0.841328903654485 0.285714285714286 4.2 4 2 small ears 0.448315934479266 0.845478307063817 0.841328903654485 0.285714285714286 4.2 4 2 abnormal anxiety-related response 0.448315934479266 0.845478307063817 0.841328903654485 0.285714285714286 4.2 4 2 abnormal associative learning 0.448315934479266 0.845478307063817 0.841328903654485 0.285714285714286 4.2 4 2 abnormal bile salt homeostasis 0.448315934479266 0.845478307063817 0.841328903654485 0.285714285714286 4.2 4 2 dehydration 0.308735943139295 0.723827199395848 0.841328903654485 0.285714285714286 4.2 4 2 abnormal suckling behavior 0.290599871829844 0.694837585907799 0.836548625792812 0.284090909090909 4.2 4 2 short femur 0.290599871829844 0.694837585907799 0.836548625792812 0.284090909090909 4.2 4 2 deafness 0.284774844552345 0.68310262856698 0.832830631900399 0.282828282828283 4.2 4 2 abnormal lens fiber morphology 0.399638894371803 0.836259035731814 0.830542635658915 0.282051282051282 4.2 4 2 abnormal long term potentiation 0.424590633422719 0.836259035731814 0.828183139534884 0.28125 4.2 4 2 abnormal heart atrium morphology 0.424590633422719 0.836259035731814 0.828183139534884 0.28125 4.2 4 2 abnormal nest building behavior 0.455149758182963 0.855770992804324 0.824502325581395 0.28 4.2 4 2 diaphragmatic hernia 0.455149758182963 0.855770992804324 0.824502325581395 0.28 4.2 4 2 abnormal cochlear outer hair cell morphology 0.455149758182963 0.855770992804324 0.824502325581395 0.28 4.2 4 2 increased liver glycogen level 0.455149758182963 0.855770992804324 0.824502325581395 0.28 4.2 4 2 increased circulating creatinine level 0.330728735591241 0.750627490678114 0.821763115197404 0.27906976744186 4.2 4 2 abnormal intestinal mucosa morphology 0.406142968704939 0.836259035731814 0.821763115197404 0.27906976744186 4.2 4 2 abnormal blood circulation 0.406142968704939 0.836259035731814 0.821763115197404 0.27906976744186 4.2 4 2 reduced long term depression 0.430906256225951 0.836259035731814 0.817958656330749 0.277777777777778 4.2 4 2 abnormal limb bone morphology 0.430906256225951 0.836259035731814 0.817958656330749 0.277777777777778 4.2 4 2 renal hypoplasia 0.430906256225951 0.836259035731814 0.817958656330749 0.277777777777778 4.2 4 2 abnormal retinal blood vessel morphology 0.430906256225951 0.836259035731814 0.817958656330749 0.277777777777778 4.2 4 2 lowered ear position 0.49525956649217 0.887577933464895 0.817958656330749 0.277777777777778 4.2 4 2 abnormal stomach glandular epithelium morphology 0.49525956649217 0.887577933464895 0.817958656330749 0.277777777777778 4.2 4 2 eye inflammation 0.49525956649217 0.887577933464895 0.817958656330749 0.277777777777778 4.2 4 2 acidosis 0.49525956649217 0.887577933464895 0.817958656330749 0.277777777777778 4.2 4 2 abnormal metacarpal bone morphology 0.49525956649217 0.887577933464895 0.817958656330749 0.277777777777778 4.2 4 2 absent allantois 0.49525956649217 0.887577933464895 0.817958656330749 0.277777777777778 4.2 4 2 decreased heart rate variability 0.49525956649217 0.887577933464895 0.817958656330749 0.277777777777778 4.2 4 2 decreased pulmonary respiratory rate 0.49525956649217 0.887577933464895 0.817958656330749 0.277777777777778 4.2 4 2 decreased fluid intake 0.49525956649217 0.887577933464895 0.817958656330749 0.277777777777778 4.2 4 2 short snout 0.314271397060467 0.733868289646829 0.817958656330749 0.277777777777778 4.2 4 2 short tail 0.34970529366632 0.788302598998614 0.815987671616699 0.27710843373494 4.2 4 2 decreased anxiety-related response 0.310574932955317 0.727795709586765 0.813968614104746 0.276422764227642 4.2 4 2 abnormal axial skeleton morphology 0.365186926438755 0.808490306080356 0.813653610771114 0.276315789473684 4.2 4 2 abnormal parietal bone morphology 0.46071467788446 0.86525312286719 0.812317562149158 0.275862068965517 4.2 4 2 absent long term depression 0.46071467788446 0.86525312286719 0.812317562149158 0.275862068965517 4.2 4 2 short sternum 0.46071467788446 0.86525312286719 0.812317562149158 0.275862068965517 4.2 4 2 abnormal epidermal layer morphology 0.382132882763672 0.821584162719559 0.810845972362656 0.27536231884058 4.2 4 2 head bobbing 0.436381195864811 0.836259035731814 0.809779069767442 0.275 4.2 4 2 increased kidney weight 0.417088454290672 0.836259035731814 0.808335613315094 0.274509803921569 4.2 4 2 absent vibrissae 0.465392725282307 0.865431460418084 0.803086680761099 0.272727272727273 4.2 4 2 head tossing 0.465392725282307 0.865431460418084 0.803086680761099 0.272727272727273 4.2 4 2 obese 0.390956618094198 0.836259035731814 0.803086680761099 0.272727272727273 4.2 4 2 abnormal joint morphology 0.421772013620073 0.836259035731814 0.803086680761099 0.272727272727273 4.2 4 2 abnormal photoreceptor outer segment morphology 0.441201659667069 0.836259035731814 0.803086680761099 0.272727272727273 4.2 4 2 abnormal long bone epiphysis morphology 0.498554511021751 0.891235606300112 0.803086680761099 0.272727272727273 4.2 4 2 intestinal ulcer 0.498554511021751 0.891235606300112 0.803086680761099 0.272727272727273 4.2 4 2 increased body size 0.498554511021751 0.891235606300112 0.803086680761099 0.272727272727273 4.2 4 2 abnormal retinal outer plexiform layer morphology 0.498554511021751 0.891235606300112 0.803086680761099 0.272727272727273 4.2 4 2 abnormal basement membrane morphology 0.498554511021751 0.891235606300112 0.803086680761099 0.272727272727273 4.2 4 2 failure of palatal shelf elevation 0.498554511021751 0.891235606300112 0.803086680761099 0.272727272727273 4.2 4 2 increased circulating creatine kinase level 0.498554511021751 0.891235606300112 0.803086680761099 0.272727272727273 4.2 4 2 domed cranium 0.409476840662949 0.836259035731814 0.799262458471761 0.271428571428571 4.2 4 2 increased white adipose tissue amount 0.469420319538187 0.865431460418084 0.795851665619108 0.27027027027027 4.2 4 2 abnormal long bone metaphysis morphology 0.469420319538187 0.865431460418084 0.795851665619108 0.27027027027027 4.2 4 2 increased insulin secretion 0.469420319538187 0.865431460418084 0.795851665619108 0.27027027027027 4.2 4 2 decreased kidney weight 0.449373948417502 0.847152479491122 0.792790697674419 0.269230769230769 4.2 4 2 abnormal kidney cortex morphology 0.501260886059863 0.895108725106898 0.792790697674419 0.269230769230769 4.2 4 2 abnormal Schwann cell morphology 0.501260886059863 0.895108725106898 0.792790697674419 0.269230769230769 4.2 4 2 small seminal vesicle 0.501260886059863 0.895108725106898 0.792790697674419 0.269230769230769 4.2 4 2 decreased compact bone thickness 0.433590910162414 0.836259035731814 0.791100312391531 0.26865671641791 4.2 4 2 maternal effect 0.433590910162414 0.836259035731814 0.791100312391531 0.26865671641791 4.2 4 2 enhanced long term potentiation 0.452896338262202 0.853146263860073 0.78874584717608 0.267857142857143 4.2 4 2 abnormal ovarian follicle morphology 0.47609754364244 0.868249735931503 0.785240310077519 0.266666666666667 4.2 4 2 cyanosis 0.375993862088648 0.811174962658726 0.782172965116279 0.265625 4.2 4 2 abnormal lens morphology 0.409170631205724 0.836259035731814 0.782172965116279 0.265625 4.2 4 2 absent kidney 0.478930896437429 0.872776999918025 0.781233981964879 0.26530612244898 4.2 4 2 abnormal epidermis stratum corneum morphology 0.478930896437429 0.872776999918025 0.781233981964879 0.26530612244898 4.2 4 2 impaired synaptic plasticity 0.505598876170236 0.902207463754277 0.779466484268126 0.264705882352941 4.2 4 2 increased susceptibility to weight gain 0.505598876170236 0.902207463754277 0.779466484268126 0.264705882352941 4.2 4 2 abnormal spatial learning 0.410373505506943 0.836259035731814 0.77680981595092 0.263803680981595 4.2 4 2 seizures 0.44169083136704 0.836259035731814 0.774908200734394 0.263157894736842 4.2 4 2 abnormal circulating amino acid level 0.483876075277552 0.877281467061835 0.774908200734394 0.263157894736842 4.2 4 2 impaired righting response 0.45321784728681 0.853428762396624 0.774908200734394 0.263157894736842 4.2 4 2 increased grooming behavior 0.507412912152249 0.904795425791196 0.774908200734394 0.263157894736842 4.2 4 2 impaired branching involved in ureteric bud morphogenesis 0.507412912152249 0.904795425791196 0.774908200734394 0.263157894736842 4.2 4 2 irregular coat pigmentation 0.54873514432399 0.947048867952626 0.774908200734394 0.263157894736842 4.2 4 2 decreased grooming behavior 0.54873514432399 0.947048867952626 0.774908200734394 0.263157894736842 4.2 4 2 delayed sexual maturation 0.54873514432399 0.947048867952626 0.774908200734394 0.263157894736842 4.2 4 2 abnormal digestive system development 0.54873514432399 0.947048867952626 0.774908200734394 0.263157894736842 4.2 4 2 abnormal photoreceptor inner segment morphology 0.54873514432399 0.947048867952626 0.774908200734394 0.263157894736842 4.2 4 2 increased left ventricle weight 0.54873514432399 0.947048867952626 0.774908200734394 0.263157894736842 4.2 4 2 abnormal social investigation 0.469115563199088 0.865431460418084 0.772970930232558 0.2625 4.2 4 2 abnormal optic nerve morphology 0.509060849801132 0.907408716503271 0.771218161683278 0.261904761904762 4.2 4 2 abnormal cranium morphology 0.451661205373126 0.851141854822463 0.769125303713988 0.261194029850746 4.2 4 2 abnormal coat appearance 0.490001642339533 0.882812274596125 0.768169868554095 0.260869565217391 4.2 4 2 abnormal food intake 0.490001642339533 0.882812274596125 0.768169868554095 0.260869565217391 4.2 4 2 abnormal cochlear ganglion morphology 0.547088232254609 0.947048867952626 0.768169868554095 0.260869565217391 4.2 4 2 abnormal sacral vertebrae morphology 0.547088232254609 0.947048867952626 0.768169868554095 0.260869565217391 4.2 4 2 decreased epididymis weight 0.547088232254609 0.947048867952626 0.768169868554095 0.260869565217391 4.2 4 2 abnormal ulna morphology 0.547088232254609 0.947048867952626 0.768169868554095 0.260869565217391 4.2 4 2 abnormal lens development 0.547088232254609 0.947048867952626 0.768169868554095 0.260869565217391 4.2 4 2 abnormal basicranium morphology 0.547088232254609 0.947048867952626 0.768169868554095 0.260869565217391 4.2 4 2 abnormal hepatocyte physiology 0.547088232254609 0.947048867952626 0.768169868554095 0.260869565217391 4.2 4 2 polyphagia 0.51329550811105 0.914629352740858 0.763428079242033 0.259259259259259 4.2 4 2 wrinkled skin 0.546009682986007 0.947048867952626 0.763428079242033 0.259259259259259 4.2 4 2 abnormal brain commissure morphology 0.546009682986007 0.947048867952626 0.763428079242033 0.259259259259259 4.2 4 2 abnormal bone trabecula morphology 0.546009682986007 0.947048867952626 0.763428079242033 0.259259259259259 4.2 4 2 abnormal cranial ganglia morphology 0.545301570687484 0.947048867952626 0.759909977494374 0.258064516129032 4.2 4 2 abnormal eyelid morphology 0.545301570687484 0.947048867952626 0.759909977494374 0.258064516129032 4.2 4 2 abnormal iris morphology 0.544576366559299 0.947048867952626 0.755038759689923 0.256410256410256 4.2 4 2 abnormal organ of Corti morphology 0.544438871427948 0.947048867952626 0.75328285559762 0.255813953488372 4.2 4 2 abnormal tibia morphology 0.544402681187455 0.947048867952626 0.751825828797625 0.25531914893617 4.2 4 2 abnormal response to novel object 0.544444520735075 0.947048867952626 0.750597355221158 0.254901960784314 4.2 4 2 abnormal CNS synaptic transmission 0.547510007676537 0.947048867952626 0.743598778482499 0.252525252525253 4.2 4 2 oligodactyly 0.577370190851999 0.947048867952626 0.736162790697674 0.25 4.2 4 2 abnormal amino acid level 0.57885127534824 0.947048867952626 0.736162790697674 0.25 4.2 4 2 decreased body temperature 0.576134711507599 0.947048867952626 0.736162790697674 0.25 4.2 4 2 abnormal diaphragm morphology 0.58553854977574 0.949186798675238 0.736162790697674 0.25 4.2 4 2 myoclonus 0.588958751452969 0.953488378938667 0.736162790697674 0.25 4.2 4 2 straub tail 0.588958751452969 0.953488378938667 0.736162790697674 0.25 4.2 4 2 enhanced coordination 0.588958751452969 0.953488378938667 0.736162790697674 0.25 4.2 4 2 decreased circulating progesterone level 0.588958751452969 0.953488378938667 0.736162790697674 0.25 4.2 4 2 abnormal foregut morphology 0.59338248498809 0.957844861393817 0.736162790697674 0.25 4.2 4 2 abnormal body weight 0.59338248498809 0.957844861393817 0.736162790697674 0.25 4.2 4 2 ocular hypertelorism 0.59338248498809 0.957844861393817 0.736162790697674 0.25 4.2 4 2 increased stereotypic behavior 0.59338248498809 0.957844861393817 0.736162790697674 0.25 4.2 4 2 abnormal sensory capabilities/reflexes/nociception 0.59338248498809 0.957844861393817 0.736162790697674 0.25 4.2 4 2 abnormal cardiac muscle contractility 0.59338248498809 0.957844861393817 0.736162790697674 0.25 4.2 4 2 decreased ovulation rate 0.59338248498809 0.957844861393817 0.736162790697674 0.25 4.2 4 2 abnormal osteoblast morphology 0.59338248498809 0.957844861393817 0.736162790697674 0.25 4.2 4 2 abnormal retinal ganglion layer morphology 0.59338248498809 0.957844861393817 0.736162790697674 0.25 4.2 4 2 anencephaly 0.599299703383211 0.965829615915605 0.736162790697674 0.25 4.2 4 2 abnormal dopamine level 0.599299703383211 0.965829615915605 0.736162790697674 0.25 4.2 4 2 abnormal trachea morphology 0.599299703383211 0.965829615915605 0.736162790697674 0.25 4.2 4 2 abnormal postnatal subventricular zone morphology 0.599299703383211 0.965829615915605 0.736162790697674 0.25 4.2 4 2 decreased circulating VLDL cholesterol level 0.599299703383211 0.965829615915605 0.736162790697674 0.25 4.2 4 2 abnormal kidney development 0.57422378526348 0.947048867952626 0.736162790697674 0.25 4.2 4 2 abnormal long bone morphology 0.602971612643758 0.971432568945174 0.724094548227221 0.245901639344262 4.2 4 2 abnormal humerus morphology 0.619281218841262 0.989492399119311 0.716266499057197 0.243243243243243 4.2 4 2 dextrocardia 0.623985213613638 0.995295427293315 0.713854827343199 0.242424242424242 4.2 4 2 impaired swimming 0.628422983371466 1 0.713854827343199 0.242424242424242 4.2 4 2 abnormal middle ear morphology 0.629763683952041 1 0.710777866880513 0.241379310344828 4.2 4 2 focal hair loss 0.629763683952041 1 0.710777866880513 0.241379310344828 4.2 4 2 abnormal spinal nerve morphology 0.629763683952041 1 0.710777866880513 0.241379310344828 4.2 4 2 abnormal hindlimb morphology 0.640027576548183 1 0.706716279069767 0.24 4.2 4 2 abnormal digestive system physiology 0.640027576548183 1 0.706716279069767 0.24 4.2 4 2 abnormal eye electrophysiology 0.670491355767035 1 0.705742840668845 0.239669421487603 4.2 4 2 corneal opacity 0.651747196649602 1 0.705057320668195 0.23943661971831 4.2 4 2 abnormal cartilage morphology 0.648604287375029 1 0.701107419712071 0.238095238095238 4.2 4 2 abnormal nervous system electrophysiology 0.667745097506602 1 0.701107419712071 0.238095238095238 4.2 4 2 hypoalgesia 0.646482131165694 1 0.701107419712071 0.238095238095238 4.2 4 2 abnormal thoracic vertebrae morphology 0.661151643821334 1 0.698730784391013 0.23728813559322 4.2 4 2 decreased threshold for auditory brainstem response 0.653998969193024 1 0.697417380660955 0.236842105263158 4.2 4 2 abnormal cued conditioning behavior 0.6694377475676 1 0.692859097127223 0.235294117647059 4.2 4 2 abnormal innervation 0.674434154572687 1 0.689173676397823 0.234042553191489 4.2 4 2 abnormal lactation 0.668169945822976 1 0.687085271317829 0.233333333333333 4.2 4 2 abnormal estrous cycle 0.668169945822976 1 0.687085271317829 0.233333333333333 4.2 4 2 abnormal male reproductive system morphology 0.680169564934751 1 0.684802595997837 0.232558139534884 4.2 4 2 abnormal excitatory postsynaptic potential 0.714661662451994 1 0.682297220646625 0.231707317073171 4.2 4 2 abnormal xiphoid process morphology 0.677767136723399 1 0.67953488372093 0.230769230769231 4.2 4 2 abnormal ocular fundus morphology 0.677767136723399 1 0.67953488372093 0.230769230769231 4.2 4 2 increased percent body fat/body weight 0.6974286583856 1 0.67953488372093 0.230769230769231 4.2 4 2 abnormal excitatory postsynaptic currents 0.718361679755359 1 0.67953488372093 0.230769230769231 4.2 4 2 increased vascular permeability 0.686825749983142 1 0.67953488372093 0.230769230769231 4.2 4 2 short limbs 0.731662657166857 1 0.676931301790965 0.229885057471264 4.2 4 2 abnormal cardiovascular system morphology 0.70329100865181 1 0.674815891472868 0.229166666666667 4.2 4 2 abnormal artery morphology 0.694652901700773 1 0.673063122923588 0.228571428571429 4.2 4 2 abnormal action potential 0.726737416792531 1 0.673063122923588 0.228571428571429 4.2 4 2 hypertension 0.709969061871959 1 0.669238900634249 0.227272727272727 4.2 4 2 decreased cardiac output 0.689990254737442 1 0.669238900634249 0.227272727272727 4.2 4 2 abnormal blood-brain barrier function 0.689990254737442 1 0.669238900634249 0.227272727272727 4.2 4 2 abnormal temporal bone morphology 0.689990254737442 1 0.669238900634249 0.227272727272727 4.2 4 2 abnormal postnatal growth/weight/body size 0.704006555237494 1 0.664921230307577 0.225806451612903 4.2 4 2 abnormal retinal photoreceptor layer morphology 0.704006555237494 1 0.664921230307577 0.225806451612903 4.2 4 2 increased anxiety-related response 0.822121163923167 1 0.656720762924544 0.223021582733813 4.2 4 2 short radius 0.72660271142687 1 0.654366925064599 0.222222222222222 4.2 4 2 head tilt 0.72660271142687 1 0.654366925064599 0.222222222222222 4.2 4 2 kidney cortex cysts 0.737177596766786 1 0.644142441860465 0.21875 4.2 4 2 increased dopamine level 0.737177596766786 1 0.644142441860465 0.21875 4.2 4 2 blistering 0.729685260982674 1 0.640141557128412 0.217391304347826 4.2 4 2 abnormal crista ampullaris morphology 0.729685260982674 1 0.640141557128412 0.217391304347826 4.2 4 2 abnormal chondrocyte physiology 0.729685260982674 1 0.640141557128412 0.217391304347826 4.2 4 2 abnormal incisor morphology 0.787030252803891 1 0.638007751937984 0.216666666666667 4.2 4 2 abnormal breathing pattern 0.756208640416004 1 0.636681332495286 0.216216216216216 4.2 4 2 abnormal hormone level 0.749899406792568 1 0.630996677740864 0.214285714285714 4.2 4 2 single kidney 0.767652469154172 1 0.6246229739253 0.212121212121212 4.2 4 2 abnormal middle ear ossicle morphology 0.767652469154172 1 0.6246229739253 0.212121212121212 4.2 4 2 abnormal retinal outer nuclear layer morphology 0.783464552742131 1 0.619926560587515 0.210526315789474 4.2 4 2 abnormal axon guidance 0.797692176473521 1 0.616322336398053 0.209302325581395 4.2 4 2 abnormal locomotor activation 0.866046114159054 1 0.614817275747508 0.208791208791209 4.2 4 2 abnormal digestive system morphology 0.765554412560196 1 0.613468992248062 0.208333333333333 4.2 4 2 abnormal digit morphology 0.845953971302993 1 0.613468992248062 0.208333333333333 4.2 4 2 abnormal phalanx morphology 0.810593738008904 1 0.613468992248062 0.208333333333333 4.2 4 2 aphagia 0.781239160577054 1 0.609238171611869 0.206896551724138 4.2 4 2 abnormal chondrocyte morphology 0.841160244848041 1 0.599836347975883 0.203703703703704 4.2 4 2 syndactyly 0.850433196026537 1 0.598912100906583 0.203389830508475 4.2 4 2 abnormal pain threshold 0.809506464265574 1 0.588930232558139 0.2 4.2 4 2 abnormal axon extension 0.849908802094488 1 0.588930232558139 0.2 4.2 4 2 abnormal vertebrae development 0.797684284442291 1 0.588930232558139 0.2 4.2 4 2 abnormal energy expenditure 0.797684284442291 1 0.588930232558139 0.2 4.2 4 2 abnormal stomach mucosa morphology 0.797684284442291 1 0.588930232558139 0.2 4.2 4 2 increased susceptibility to pharmacologically induced seizures 0.917961541287559 1 0.582795542635659 0.197916666666667 4.2 4 2 abnormal systemic arterial blood pressure 0.843358875930972 1 0.572571059431525 0.194444444444444 4.2 4 2 abnormal nose morphology 0.834826442432313 1 0.56993248312078 0.193548387096774 4.2 4 2 abnormal nasal bone morphology 0.826235986280123 1 0.566279069767442 0.192307692307692 4.2 4 2 abnormal ureter morphology 0.826235986280123 1 0.566279069767442 0.192307692307692 4.2 4 2 thick skin 0.826235986280123 1 0.566279069767442 0.192307692307692 4.2 4 2 abnormal brain wave pattern 0.882494118782428 1 0.566279069767442 0.192307692307692 4.2 4 2 abnormal vibrissa morphology 0.870094090672613 1 0.560885935769657 0.19047619047619 4.2 4 2 impaired skeletal muscle contractility 0.863693930884465 1 0.557096165933375 0.189189189189189 4.2 4 2 abnormal lumbar vertebrae morphology 0.857360791432049 1 0.552122093023256 0.1875 4.2 4 2 abnormal limb morphology 0.932617401719122 1 0.549668217054264 0.186666666666667 4.2 4 2 abnormal long bone epiphyseal plate proliferative zone 0.90904993794948 1 0.545305770887166 0.185185185185185 4.2 4 2 increased circulating luteinizing hormone level 0.873493623695294 1 0.525830564784053 0.178571428571429 4.2 4 2 abnormal cartilage development 0.91449312402057 1 0.52349354005168 0.177777777777778 4.2 4 2 abnormal autopod morphology 0.91449312402057 1 0.52349354005168 0.177777777777778 4.2 4 2 abnormal bone remodeling 0.894833194826789 1 0.519644322845417 0.176470588235294 4.2 4 2 decreased pancreatic beta cell number 0.894833194826789 1 0.519644322845417 0.176470588235294 4.2 4 2 short ulna 0.924471056572734 1 0.502745320476461 0.170731707317073 4.2 4 2 abnormal reflex 0.923544393997526 1 0.49077519379845 0.166666666666667 4.2 4 2 abnormal cochlea morphology 0.953443979300361 1 0.49077519379845 0.166666666666667 4.2 4 2 abnormal synaptic transmission 0.909354671360798 1 0.49077519379845 0.166666666666667 4.2 4 2 decreased food intake 0.978557367795063 1 0.484562849573153 0.164556962025316 4.2 4 2 abnormal femur morphology 0.970752943212329 1 0.483450190905935 0.164179104477612 4.2 4 2 abnormal forelimb morphology 0.966243736220686 1 0.448099089989889 0.152173913043478 4.2 4 2 impaired behavioral response to xenobiotic 0.962873703556871 1 0.420664451827242 0.142857142857143 4.2 4 2 abnormal inhibitory postsynaptic currents 0.9952953331185 1 0.389733242134063 0.132352941176471 4.2 4 2 decreased brain cholesterol level 8.08363976287179e-05 0.00283212026903431 4.70903522205207 0.857142857142857 4.4 4 4 delayed brain development 0.000452203685726243 0.0110823317068377 4.57822868810618 0.833333333333333 4.4 4 4 abnormal immature B cell morphology 0.000452203685726243 0.0110823317068377 4.57822868810618 0.833333333333333 4.4 4 4 absent brachial lymph nodes 0.000452203685726243 0.0110823317068377 4.57822868810618 0.833333333333333 4.4 4 4 absent inguinal lymph nodes 1.05600274539932e-05 0.00050515515945785 4.39509954058193 0.8 4.4 4 4 increased B-1 B cell number 2.64270549372547e-07 1.80102189469647e-05 4.3166156202144 0.785714285714286 4.4 4 4 absent cervical lymph nodes 5.51958991037364e-05 0.00203407109660066 4.27301344223243 0.777777777777778 4.4 4 4 colon polyps 0.000280841721449617 0.00751176109791314 4.12040581929556 0.75 4.4 4 4 elevated level of mitotic sister chromatid exchange 0.000280841721449617 0.00751176109791314 4.12040581929556 0.75 4.4 4 4 abnormal NK cell morphology 0.000280841721449617 0.00751176109791314 4.12040581929556 0.75 4.4 4 4 pleural effusion 0.000280841721449617 0.00751176109791314 4.12040581929556 0.75 4.4 4 4 increased brain apoptosis 0.000280841721449617 0.00751176109791314 4.12040581929556 0.75 4.4 4 4 abnormal Peyer's patch follicle morphology 1.07432241621127e-07 8.35117815726726e-06 3.96779819635869 0.722222222222222 4.4 4 4 absent popliteal lymph nodes 0.00138062190597006 0.0265196678849461 3.92419601837672 0.714285714285714 4.4 4 4 decreased DN2 thymocyte number 0.00138062190597006 0.0265196678849461 3.92419601837672 0.714285714285714 4.4 4 4 absent axillary lymph nodes 0.00015934626628647 0.00501739034667842 3.84571209800919 0.7 4.4 4 4 decreased B cell proliferation 5.2841193777853e-25 4.38141565074698e-22 3.68576385523485 0.670886075949367 4.4 4 4 decreased level of surface class I molecules 0.000732133366141378 0.0164070427772674 3.66258295048494 0.666666666666667 4.4 4 4 abnormal thymus physiology 0.000732133366141378 0.0164070427772674 3.66258295048494 0.666666666666667 4.4 4 4 increased neuronal precursor cell number 0.000732133366141378 0.0164070427772674 3.66258295048494 0.666666666666667 4.4 4 4 abnormal Peyer's patch T cell area morphology 7.15535284269891e-07 4.44973504905339e-05 3.57101837672282 0.65 4.4 4 4 vascular smooth muscle hypoplasia 4.61411829730432e-05 0.00176578757916069 3.53177641653905 0.642857142857143 4.4 4 4 increased pre-B cell number 4.93184107105495e-08 4.23032919456868e-06 3.51607963246554 0.64 4.4 4 4 abnormal B cell differentiation 1.7852628323034e-25 1.98213908067228e-22 3.50159029332077 0.637362637362637 4.4 4 4 binucleate 0.00321358888017079 0.0487567372248807 3.43367151607963 0.625 4.4 4 4 abnormal kidney epithelium morphology 0.00321358888017079 0.0487567372248807 3.43367151607963 0.625 4.4 4 4 abnormal maxillary prominence morphology 0.00321358888017079 0.0487567372248807 3.43367151607963 0.625 4.4 4 4 abnormal macrophage activation involved in immune response 0.00321358888017079 0.0487567372248807 3.43367151607963 0.625 4.4 4 4 arrested B cell differentiation 3.74098470486414e-11 5.16983302963863e-09 3.34992343032159 0.609756097560976 4.4 4 4 abnormal humoral immune response 1.9920995785651e-25 1.98213908067228e-22 3.29632465543645 0.6 4.4 4 4 abnormal trophectoderm morphology 9.95228762465388e-05 0.0033912760912776 3.29632465543645 0.6 4.4 4 4 acrania 0.00159131401592374 0.0298746687895118 3.29632465543645 0.6 4.4 4 4 abnormal gas homeostasis 0.00159131401592374 0.0298746687895118 3.29632465543645 0.6 4.4 4 4 decreased transitional stage T2 B cell number 0.00159131401592374 0.0298746687895118 3.29632465543645 0.6 4.4 4 4 increased brain size 5.07025406348211e-05 0.0019109480277139 3.23169083866318 0.588235294117647 4.4 4 4 increased osteosarcoma incidence 0.000789812265603424 0.0173863540768895 3.20476008167432 0.583333333333333 4.4 4 4 abnormal B cell proliferation 0.000789812265603424 0.0173863540768895 3.20476008167432 0.583333333333333 4.4 4 4 abnormal maternal decidual layer morphology 0.000393183594572781 0.00987923425757367 3.13935681470138 0.571428571428571 4.4 4 4 decreased B-1 B cell number 4.44390953001259e-09 4.25162498304089e-07 3.09910865041034 0.564102564102564 4.4 4 4 increased intestinal adenocarcinoma incidence 0.000196319826916378 0.00584844993358672 3.09030436447167 0.5625 4.4 4 4 increased B cell derived lymphoma incidence 4.40969887694326e-11 5.92925727372776e-09 3.07656967840735 0.56 4.4 4 4 increased B cell proliferation 8.58699110244311e-13 1.85740351020237e-10 3.07284501777974 0.559322033898305 4.4 4 4 abnormal germ cell morphology 0.00631540827270756 0.082935268424667 3.05215245873745 0.555555555555556 4.4 4 4 abnormal gut-associated lymphoid tissue morphology 0.00631540827270756 0.082935268424667 3.05215245873745 0.555555555555556 4.4 4 4 abnormal leukopoiesis 0.00631540827270756 0.082935268424667 3.05215245873745 0.555555555555556 4.4 4 4 decreased transitional stage T1 B cell number 0.00631540827270756 0.082935268424667 3.05215245873745 0.555555555555556 4.4 4 4 abnormal thymocyte activation 4.93371474176153e-05 0.00187368174353157 3.02163093415008 0.55 4.4 4 4 intestinal inflammation 2.48185049472501e-05 0.00107367010532669 2.9966587776695 0.545454545454545 4.4 4 4 vasculitis 0.00304528865330977 0.0479440223108105 2.9966587776695 0.545454545454545 4.4 4 4 abnormal T cell subpopulation ratio 1.44807132737552e-06 8.57637482582526e-05 2.83017773446564 0.515151515151515 4.4 4 4 increased autoantibody level 1.88736771014433e-07 1.40144094895046e-05 2.81737150037303 0.512820512820513 4.4 4 4 decreased IgM level 6.80602575171369e-16 2.82166484289797e-13 2.77525615320251 0.505154639175258 4.4 4 4 abnormal lymphocyte physiology 4.24033929260017e-08 3.7009978913484e-06 2.74693721286371 0.5 4.4 4 4 abnormal myelopoiesis 8.33351987005774e-08 6.90987689225621e-06 2.74693721286371 0.5 4.4 4 4 abnormal spleen marginal zone morphology 9.72638573871813e-06 0.000469793874273036 2.74693721286371 0.5 4.4 4 4 abnormal mesenteric lymph node morphology 0.000153520630362465 0.00492751700679524 2.74693721286371 0.5 4.4 4 4 increased mammary adenocarcinoma incidence 0.000308347192627333 0.00807382780695254 2.74693721286371 0.5 4.4 4 4 abnormal level of surface class II molecules 0.0012612718612606 0.0249993127879342 2.74693721286371 0.5 4.4 4 4 decreased liver cholesterol level 0.0012612718612606 0.0249993127879342 2.74693721286371 0.5 4.4 4 4 decreased fibroblast apoptosis 0.0012612718612606 0.0249993127879342 2.74693721286371 0.5 4.4 4 4 abnormal thymus involution 0.00530076504101609 0.0716611578235192 2.74693721286371 0.5 4.4 4 4 increased growth rate 0.00530076504101609 0.0716611578235192 2.74693721286371 0.5 4.4 4 4 abnormal vascular endothelial cell development 0.00530076504101609 0.0716611578235192 2.74693721286371 0.5 4.4 4 4 abnormal prostate gland epithelium morphology 0.0110395025294914 0.121507798858893 2.74693721286371 0.5 4.4 4 4 abnormal immune cell physiology 0.0110395025294914 0.121507798858893 2.74693721286371 0.5 4.4 4 4 peritoneal inflammation 0.0110395025294914 0.121507798858893 2.74693721286371 0.5 4.4 4 4 absent seminal vesicle 0.0110395025294914 0.121507798858893 2.74693721286371 0.5 4.4 4 4 absent CD4-positive, alpha beta T cells 0.0110395025294914 0.121507798858893 2.74693721286371 0.5 4.4 4 4 osteosclerosis 0.0110395025294914 0.121507798858893 2.74693721286371 0.5 4.4 4 4 abnormal left subclavian artery morphology 0.0110395025294914 0.121507798858893 2.74693721286371 0.5 4.4 4 4 thin ventricle myocardium compact layer 0.0110395025294914 0.121507798858893 2.74693721286371 0.5 4.4 4 4 lethality during fetal growth through weaning, complete penetrance 0.0110395025294914 0.121507798858893 2.74693721286371 0.5 4.4 4 4 decreased Peyer's patch number 3.84430848137118e-05 0.0015549133898229 2.74693721286371 0.5 4.4 4 4 increased effector memory CD4-positive, alpha-beta T cell number 0.000621983694109643 0.0142597644156474 2.74693721286371 0.5 4.4 4 4 abnormal spleen periarteriolar lymphoid sheath morphology 0.0025746310511719 0.0426959649319339 2.74693721286371 0.5 4.4 4 4 lysosomal protein accumulation 0.0025746310511719 0.0426959649319339 2.74693721286371 0.5 4.4 4 4 decreased B cell number 8.03601275328143e-30 3.99791634475751e-26 2.69359862620616 0.490291262135922 4.4 4 4 pale kidney 1.61602607199151e-05 0.000747359259081745 2.65832633502939 0.483870967741935 4.4 4 4 abnormal CD8-positive, alpha-beta T cell physiology 3.20495855967031e-05 0.00132499350781561 2.65221524000634 0.482758620689655 4.4 4 4 spleen hyperplasia 3.12288197830648e-11 4.43895366916422e-09 2.63705972434916 0.48 4.4 4 4 abnormal immune system morphology 2.281222625647e-07 1.62129750894198e-05 2.6275051601305 0.478260869565217 4.4 4 4 abnormal B cell morphology 0.000253356647992713 0.00700249624313194 2.6275051601305 0.478260869565217 4.4 4 4 increased T cell proliferation 3.78004740176773e-15 1.38818984102931e-12 2.61857566086073 0.476635514018692 4.4 4 4 abnormal ectoplacental cone morphology 0.00206227860550723 0.0366422716514231 2.58535267093055 0.470588235294118 4.4 4 4 abnormal lymph node B cell domain morphology 0.00418973685736988 0.05989638179717 2.56380806533946 0.466666666666667 4.4 4 4 abnormal dendritic cell morphology 0.00418973685736988 0.05989638179717 2.56380806533946 0.466666666666667 4.4 4 4 decreased thymocyte apoptosis 0.00418973685736988 0.05989638179717 2.56380806533946 0.466666666666667 4.4 4 4 abnormal T cell differentiation 1.37866203007407e-13 3.26611599981833e-11 2.55655542583355 0.465346534653465 4.4 4 4 extramedullary hematopoiesis 5.79841367652108e-14 1.44235540203462e-11 2.53962119679852 0.462264150943396 4.4 4 4 abnormal leukocyte cell number 0.000202641288086059 0.00589555794285465 2.53563435033573 0.461538461538462 4.4 4 4 increased leukemia incidence 0.000202641288086059 0.00589555794285465 2.53563435033573 0.461538461538462 4.4 4 4 increased thymocyte apoptosis 0.000202641288086059 0.00589555794285465 2.53563435033573 0.461538461538462 4.4 4 4 lymphoid hypoplasia 0.00857235737085361 0.101060374218002 2.53563435033573 0.461538461538462 4.4 4 4 abnormal telomere length 0.00857235737085361 0.101060374218002 2.53563435033573 0.461538461538462 4.4 4 4 abnormal exocrine pancreas morphology 0.00857235737085361 0.101060374218002 2.53563435033573 0.461538461538462 4.4 4 4 small pituitary gland 0.00857235737085361 0.101060374218002 2.53563435033573 0.461538461538462 4.4 4 4 abnormal cell cycle 6.48924547651051e-15 2.01774976535249e-12 2.53195951794394 0.460869565217391 4.4 4 4 abnormal liver development 2.08644075737136e-05 0.000926789532850226 2.5114854517611 0.457142857142857 4.4 4 4 abnormal sphenoid bone morphology 0.0177013474263094 0.163384421977531 2.49721564805791 0.454545454545455 4.4 4 4 abnormal stomach epithelium morphology 0.0177013474263094 0.163384421977531 2.49721564805791 0.454545454545455 4.4 4 4 abnormal large intestine morphology 0.0177013474263094 0.163384421977531 2.49721564805791 0.454545454545455 4.4 4 4 abnormal food preference 0.0177013474263094 0.163384421977531 2.49721564805791 0.454545454545455 4.4 4 4 abnormal proximal-distal axis patterning 0.0177013474263094 0.163384421977531 2.49721564805791 0.454545454545455 4.4 4 4 abnormal dorsal-ventral polarity of the somites 0.0177013474263094 0.163384421977531 2.49721564805791 0.454545454545455 4.4 4 4 decreased palatine bone horizontal plate size 0.0177013474263094 0.163384421977531 2.49721564805791 0.454545454545455 4.4 4 4 chylous ascites 0.0177013474263094 0.163384421977531 2.49721564805791 0.454545454545455 4.4 4 4 hypolactation 0.0177013474263094 0.163384421977531 2.49721564805791 0.454545454545455 4.4 4 4 abnormal mitochondrial ATP synthesis coupled electron transport 8.0753547033343e-05 0.00283212026903431 2.48110457936077 0.451612903225806 4.4 4 4 increased skin tumor incidence 0.00160373605291963 0.029959554916849 2.47224349157734 0.45 4.4 4 4 abnormal cell nucleus morphology 1.74466400128371e-06 0.000100926783795191 2.4547098497931 0.446808510638298 4.4 4 4 decreased lymphocyte cell number 4.17257979918532e-15 1.38818984102931e-12 2.44649095520674 0.4453125 4.4 4 4 abnormal bile duct morphology 0.0032145145346253 0.0487567372248807 2.44172196698996 0.444444444444444 4.4 4 4 abnormal pregnancy 0.0032145145346253 0.0487567372248807 2.44172196698996 0.444444444444444 4.4 4 4 abnormal macrophage chemotaxis 0.0032145145346253 0.0487567372248807 2.44172196698996 0.444444444444444 4.4 4 4 increased effector memory CD8-positive, alpha-beta T cell number 0.0032145145346253 0.0487567372248807 2.44172196698996 0.444444444444444 4.4 4 4 abnormal hypoglossal nerve topology 0.0032145145346253 0.0487567372248807 2.44172196698996 0.444444444444444 4.4 4 4 decreased IgA level 7.05965467693975e-07 4.44579519212345e-05 2.42998291907174 0.442307692307692 4.4 4 4 decreased IgG level 5.11982998648868e-13 1.15777973558096e-10 2.42522384559138 0.441441441441441 4.4 4 4 abnormal spleen red pulp morphology 6.29870595962773e-05 0.00228730380650715 2.42376812899739 0.441176470588235 4.4 4 4 decreased double-positive T cell number 8.84989900734143e-12 1.41909916393302e-09 2.41730474732006 0.44 4.4 4 4 increased hepatocellular carcinoma incidence 2.85566500235472e-07 1.91985586306956e-05 2.40959404637167 0.43859649122807 4.4 4 4 abnormal erythropoiesis 3.6268417783008e-12 6.93982224886403e-10 2.40684022460439 0.438095238095238 4.4 4 4 decreased mast cell number 0.00646743185434377 0.082935268424667 2.40357006125574 0.4375 4.4 4 4 abnormal hematopoietic stem cell physiology 0.0012252105398351 0.0245783162729017 2.38864105466409 0.434782608695652 4.4 4 4 increased erythrocyte cell number 2.22552879298284e-07 1.60463851378111e-05 2.38067891781521 0.433333333333333 4.4 4 4 increased incidence of induced tumors 0.0024258384083849 0.0412584131202824 2.35451761102603 0.428571428571429 4.4 4 4 abnormal blood flow velocity 0.0130706521106149 0.129139557286175 2.35451761102603 0.428571428571429 4.4 4 4 increased lactate dehydrogenase level 0.0130706521106149 0.129139557286175 2.35451761102603 0.428571428571429 4.4 4 4 increased hemangioma incidence 0.0130706521106149 0.129139557286175 2.35451761102603 0.428571428571429 4.4 4 4 failure of zygotic cell division 0.0130706521106149 0.129139557286175 2.35451761102603 0.428571428571429 4.4 4 4 absent olfactory bulb 0.0130706521106149 0.129139557286175 2.35451761102603 0.428571428571429 4.4 4 4 abnormal positive T cell selection 0.0130706521106149 0.129139557286175 2.35451761102603 0.428571428571429 4.4 4 4 increased stomach tumor incidence 0.0130706521106149 0.129139557286175 2.35451761102603 0.428571428571429 4.4 4 4 thymus hypoplasia 1.31692035021175e-14 3.8539286719432e-12 2.34883037041969 0.427536231884058 4.4 4 4 increased double-negative T cell number 3.31117039100603e-07 2.19640969270067e-05 2.34165139457234 0.426229508196721 4.4 4 4 increased spleen weight 4.9046675637328e-12 8.41404176881748e-10 2.3336811719904 0.424778761061947 4.4 4 4 myeloid hyperplasia 0.000183869131153634 0.00561195661036398 2.33073460485405 0.424242424242424 4.4 4 4 decreased bone resorption 0.000925478757346839 0.0200185079034805 2.32433148780775 0.423076923076923 4.4 4 4 trabecula carnea hypoplasia 1.47395384065044e-05 0.000691784939361883 2.31963586864046 0.422222222222222 4.4 4 4 enlarged spleen 1.45856274313713e-27 2.4187832157024e-24 2.3081902969202 0.420138888888889 4.4 4 4 autoimmune response 0.000357286194196318 0.00919270447493324 2.30388282369214 0.419354838709677 4.4 4 4 abnormal CD8-positive, alpha beta T cell morphology 0.000357286194196318 0.00919270447493324 2.30388282369214 0.419354838709677 4.4 4 4 abnormal lysosome morphology 0.000139139144072166 0.0044949171542794 2.28911434405309 0.416666666666667 4.4 4 4 increased hemangiosarcoma incidence 0.00181262626282858 0.0333993172502673 2.28911434405309 0.416666666666667 4.4 4 4 abnormal inner cell mass apoptosis 0.00181262626282858 0.0333993172502673 2.28911434405309 0.416666666666667 4.4 4 4 interstitial pneumonia 0.0265589062729474 0.208079620012462 2.28911434405309 0.416666666666667 4.4 4 4 altered tumor susceptibility 0.0265589062729474 0.208079620012462 2.28911434405309 0.416666666666667 4.4 4 4 small intestinal inflammation 0.0265589062729474 0.208079620012462 2.28911434405309 0.416666666666667 4.4 4 4 decreased left ventricle systolic pressure 0.0265589062729474 0.208079620012462 2.28911434405309 0.416666666666667 4.4 4 4 abnormal defecation 0.0265589062729474 0.208079620012462 2.28911434405309 0.416666666666667 4.4 4 4 abnormal fatty acid level 0.0265589062729474 0.208079620012462 2.28911434405309 0.416666666666667 4.4 4 4 decreased renal glomerular filtration rate 0.0265589062729474 0.208079620012462 2.28911434405309 0.416666666666667 4.4 4 4 decreased mammary gland epithelial cell proliferation 0.0265589062729474 0.208079620012462 2.28911434405309 0.416666666666667 4.4 4 4 increased fibrosarcoma incidence 0.0265589062729474 0.208079620012462 2.28911434405309 0.416666666666667 4.4 4 4 abnormal vitelline vein connection 0.0265589062729474 0.208079620012462 2.28911434405309 0.416666666666667 4.4 4 4 increased double-positive T cell number 0.000693799171653868 0.0158332609127431 2.27332734857686 0.413793103448276 4.4 4 4 abnormal cell death 2.14964009328952e-05 0.00094641234195711 2.26920900193089 0.41304347826087 4.4 4 4 decreased T cell proliferation 3.57029614577025e-14 9.34853859221421e-12 2.26436716195522 0.412162162162162 4.4 4 4 hyperlipidemia 0.00955103912852932 0.110503301545194 2.26218358706423 0.411764705882353 4.4 4 4 increased regulatory T cell number 0.00955103912852932 0.110503301545194 2.26218358706423 0.411764705882353 4.4 4 4 abnormal circulating chemokine level 0.00955103912852932 0.110503301545194 2.26218358706423 0.411764705882353 4.4 4 4 abnormal dendritic cell physiology 1.35066269134591e-10 1.63891387547461e-08 2.25916331525239 0.411214953271028 4.4 4 4 abnormal neural tube closure 1.82764572634628e-08 1.65318863428595e-06 2.250502776804 0.409638554216867 4.4 4 4 increased adenoma incidence 0.00354957358917292 0.0528716425333392 2.24749408325212 0.409090909090909 4.4 4 4 abnormal definitive hematopoiesis 2.95944491290615e-09 2.96657051553708e-07 2.24480890513593 0.408602150537634 4.4 4 4 increased T cell derived lymphoma incidence 1.62240803981565e-05 0.000747359259081745 2.2423977247867 0.408163265306122 4.4 4 4 decreased platelet aggregation 6.42646462139377e-06 0.000322946075671051 2.23824513640746 0.407407407407407 4.4 4 4 increased fibroblast apoptosis 0.000517402507636398 0.0123753724783225 2.23188648545176 0.40625 4.4 4 4 abnormal chromosome morphology 0.000200847503153468 0.00589555794285465 2.22724638880841 0.405405405405405 4.4 4 4 abnormal spleen white pulp morphology 7.85430170739125e-05 0.00279108221387653 2.22371107708014 0.404761904761905 4.4 4 4 abnormal midbrain development 0.000384424936330842 0.00975772478696907 2.19754977029096 0.4 4.4 4 4 increased metastatic potential 0.000995451359058229 0.0212548090614364 2.19754977029096 0.4 4.4 4 4 decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 0.00260793516806945 0.0431045762828755 2.19754977029096 0.4 4.4 4 4 abnormal optic stalk morphology 0.00694740136344384 0.0866248666243938 2.19754977029096 0.4 4.4 4 4 abnormal sperm mitochondrial sheath morphology 0.00694740136344384 0.0866248666243938 2.19754977029096 0.4 4.4 4 4 macrocytosis 0.0189912622794449 0.171162191739562 2.19754977029096 0.4 4.4 4 4 abnormal prostate gland morphology 0.0189912622794449 0.171162191739562 2.19754977029096 0.4 4.4 4 4 abnormal pericyte morphology 0.0189912622794449 0.171162191739562 2.19754977029096 0.4 4.4 4 4 liver vascular congestion 0.0189912622794449 0.171162191739562 2.19754977029096 0.4 4.4 4 4 decreased brown adipose tissue mass 0.0189912622794449 0.171162191739562 2.19754977029096 0.4 4.4 4 4 abnormal CD4-positive, alpha-beta T cell physiology 8.14713325026134e-07 5.00394912593212e-05 2.1665983650756 0.394366197183099 4.4 4 4 subcutaneous edema 0.00191118684343777 0.0344498353119671 2.1583078101072 0.392857142857143 4.4 4 4 liver inflammation 2.35676049663214e-10 2.79163892160593e-08 2.1517674834099 0.391666666666667 4.4 4 4 spleen hypoplasia 3.58422521563429e-09 3.49637655838835e-07 2.14522715671261 0.39047619047619 4.4 4 4 abnormal phrenic nerve morphology 0.0135833729610137 0.130710407120007 2.13650672111622 0.388888888888889 4.4 4 4 abnormal thymus cortex morphology 0.0135833729610137 0.130710407120007 2.13650672111622 0.388888888888889 4.4 4 4 abnormal thymus medulla morphology 0.0135833729610137 0.130710407120007 2.13650672111622 0.388888888888889 4.4 4 4 increased gastrointestinal tumor incidence 0.0135833729610137 0.130710407120007 2.13650672111622 0.388888888888889 4.4 4 4 decreased tumor latency 0.0135833729610137 0.130710407120007 2.13650672111622 0.388888888888889 4.4 4 4 increased tumor incidence 2.45594512798829e-10 2.84147139807948e-08 2.12666106802351 0.387096774193548 4.4 4 4 thrombocytopenia 9.12787401926766e-12 1.41909916393302e-09 2.12177219200507 0.386206896551724 4.4 4 4 increased macrophage cell number 1.79618934608016e-05 0.0008143686823276 2.12044276080707 0.385964912280702 4.4 4 4 increased B cell number 1.12287854651253e-09 1.24140461531108e-07 2.11302862527977 0.384615384615385 4.4 4 4 abnormal tail bud morphology 0.0378004993367561 0.265243278138733 2.11302862527977 0.384615384615385 4.4 4 4 small otic vesicle 0.0378004993367561 0.265243278138733 2.11302862527977 0.384615384615385 4.4 4 4 absent hypoglossal nerve 0.0378004993367561 0.265243278138733 2.11302862527977 0.384615384615385 4.4 4 4 abnormal cytokine secretion 3.81720972042495e-12 7.03356235522746e-10 2.10479604622024 0.383116883116883 4.4 4 4 decreased cytotoxic T cell cytolysis 0.00102249749160655 0.0217389958151392 2.10059904513107 0.382352941176471 4.4 4 4 abnormal embryo turning 3.35012571573962e-05 0.00136613733080366 2.09766114436865 0.381818181818182 4.4 4 4 abnormal salivary gland morphology 0.00972990164348013 0.11078896707319 2.09290454313425 0.380952380952381 4.4 4 4 liver degeneration 0.00972990164348013 0.11078896707319 2.09290454313425 0.380952380952381 4.4 4 4 abnormal erythrocyte physiology 0.00972990164348013 0.11078896707319 2.09290454313425 0.380952380952381 4.4 4 4 increased acute inflammation 0.00972990164348013 0.11078896707319 2.09290454313425 0.380952380952381 4.4 4 4 embryonic lethality at implantation, complete penetrance 0.00972990164348013 0.11078896707319 2.09290454313425 0.380952380952381 4.4 4 4 absent segment of posterior cerebral artery 0.00972990164348013 0.11078896707319 2.09290454313425 0.380952380952381 4.4 4 4 kidney inflammation 8.45753432621569e-05 0.00293319344971021 2.08767228177642 0.38 4.4 4 4 decreased granulocyte number 0.00265514597619459 0.0433093483002232 2.08388340286212 0.379310344827586 4.4 4 4 increased mortality induced by gamma-irradiation 0.00265514597619459 0.0433093483002232 2.08388340286212 0.379310344827586 4.4 4 4 decreased trophoblast giant cell number 0.00265514597619459 0.0433093483002232 2.08388340286212 0.379310344827586 4.4 4 4 increased susceptibility to induced arthritis 0.00265514597619459 0.0433093483002232 2.08388340286212 0.379310344827586 4.4 4 4 increased inflammatory response 7.77091905543545e-08 6.55259700013413e-06 2.08188925606512 0.378947368421053 4.4 4 4 decreased T cell number 2.91462280023443e-12 5.80009937246653e-10 2.08153006192157 0.37888198757764 4.4 4 4 increased granulocyte number 2.16351581553189e-06 0.000123718289451392 2.07876329622118 0.378378378378378 4.4 4 4 abnormal embryonic hematopoiesis 0.00192716336282442 0.0344879055037824 2.06020290964778 0.375 4.4 4 4 decreased susceptibility to parasitic infection 0.00192716336282442 0.0344879055037824 2.06020290964778 0.375 4.4 4 4 hemolytic anemia 0.0069825154071556 0.0868450353764978 2.06020290964778 0.375 4.4 4 4 absent mandible 0.0265055605345056 0.208079620012462 2.06020290964778 0.375 4.4 4 4 disorganized yolk sac vascular plexus 0.0265055605345056 0.208079620012462 2.06020290964778 0.375 4.4 4 4 abnormal epicardium morphology 0.0265055605345056 0.208079620012462 2.06020290964778 0.375 4.4 4 4 sepsis 0.0265055605345056 0.208079620012462 2.06020290964778 0.375 4.4 4 4 anemia 4.18549700812856e-15 1.38818984102931e-12 2.05694824470363 0.374407582938389 4.4 4 4 abnormal spleen morphology 1.21671533121299e-12 2.52214948866026e-10 2.05230941190967 0.373563218390805 4.4 4 4 impaired hematopoiesis 0.000115447908720171 0.0038807658505598 2.04673753115335 0.372549019607843 4.4 4 4 abnormal atrioventricular cushion morphology 0.00502033184967549 0.0688048235596022 2.03476830582497 0.37037037037037 4.4 4 4 increased brain weight 0.00502033184967549 0.0688048235596022 2.03476830582497 0.37037037037037 4.4 4 4 abnormal fetal cardiomyocyte proliferation 0.00502033184967549 0.0688048235596022 2.03476830582497 0.37037037037037 4.4 4 4 abnormal allantois morphology 0.000291592659501793 0.00772445553159218 2.03034489646448 0.369565217391304 4.4 4 4 abnormal stationary movement 0.0187012116320518 0.170088716397546 2.0240589989522 0.368421052631579 4.4 4 4 increased susceptibility to ischemic brain injury 0.0187012116320518 0.170088716397546 2.0240589989522 0.368421052631579 4.4 4 4 increased liver adenoma incidence 0.0187012116320518 0.170088716397546 2.0240589989522 0.368421052631579 4.4 4 4 increased sarcoma incidence 0.000213138051807651 0.0060940333778337 2.01815795230803 0.36734693877551 4.4 4 4 abnormal nervous system morphology 2.93533232166575e-06 0.000161518174133709 2.01673871324171 0.367088607594937 4.4 4 4 abnormal response to infection 2.93533232166575e-06 0.000161518174133709 2.01673871324171 0.367088607594937 4.4 4 4 gastrointestinal hemorrhage 0.00361602180716831 0.0532010600146933 2.01442062276672 0.366666666666667 4.4 4 4 salivary gland inflammation 0.00361602180716831 0.0532010600146933 2.01442062276672 0.366666666666667 4.4 4 4 absent corpus luteum 0.000155828501499498 0.00493957116234213 2.00737719401579 0.365384615384615 4.4 4 4 pale liver 7.26761964489527e-06 0.000354474585621117 2.00452174992757 0.364864864864865 4.4 4 4 abnormal T cell activation 7.26761964489527e-06 0.000354474585621117 2.00452174992757 0.364864864864865 4.4 4 4 increased activated T cell number 0.0132615176745128 0.129139557286175 1.99777251844633 0.363636363636364 4.4 4 4 abnormal lysosome physiology 0.0132615176745128 0.129139557286175 1.99777251844633 0.363636363636364 4.4 4 4 abnormal vascular branching morphogenesis 0.0132615176745128 0.129139557286175 1.99777251844633 0.363636363636364 4.4 4 4 increased mammary gland tumor incidence 0.0132615176745128 0.129139557286175 1.99777251844633 0.363636363636364 4.4 4 4 increased bone volume 0.0132615176745128 0.129139557286175 1.99777251844633 0.363636363636364 4.4 4 4 impaired humoral immune response 0.0132615176745128 0.129139557286175 1.99777251844633 0.363636363636364 4.4 4 4 increased circulating calcium level 0.000113958253489285 0.00385675041570881 1.99777251844633 0.363636363636364 4.4 4 4 decreased erythrocyte cell number 1.05914856823114e-10 1.31731603173748e-08 1.99459135201568 0.363057324840764 4.4 4 4 microcephaly 1.80061417198062e-05 0.0008143686823276 1.99053421222008 0.36231884057971 4.4 4 4 abnormal T-helper 1 physiology 0.000391802764100299 0.00987923425757367 1.98714606888013 0.361702127659574 4.4 4 4 abnormal trophoblast giant cell morphology 0.00188507593525635 0.0342327377049549 1.98389909817934 0.361111111111111 4.4 4 4 lung inflammation 2.8101474273007e-09 2.91260071892104e-07 1.9794106386812 0.360294117647059 4.4 4 4 increased monocyte cell number 3.45207929326151e-07 2.25974927420737e-05 1.97779479326187 0.36 4.4 4 4 increased cellular sensitivity to ionizing radiation 0.00944321679164154 0.110023427490437 1.97779479326187 0.36 4.4 4 4 anophthalmia 1.56290303046082e-06 9.14757950181478e-05 1.9753256362166 0.359550561797753 4.4 4 4 impaired macrophage chemotaxis 0.00136397829951188 0.0264038600780996 1.97216005026112 0.358974358974359 4.4 4 4 increased hepatocyte apoptosis 0.00136397829951188 0.0264038600780996 1.97216005026112 0.358974358974359 4.4 4 4 failure of heart looping 0.00136397829951188 0.0264038600780996 1.97216005026112 0.358974358974359 4.4 4 4 decreased trabecular bone volume 0.00136397829951188 0.0264038600780996 1.97216005026112 0.358974358974359 4.4 4 4 abnormal reproductive system morphology 0.000988169407864323 0.0211902707074354 1.96209800918836 0.357142857142857 4.4 4 4 lymphoid hyperplasia 0.00674763463091867 0.0852017316975137 1.96209800918836 0.357142857142857 4.4 4 4 small superior cervical ganglion 0.00674763463091867 0.0852017316975137 1.96209800918836 0.357142857142857 4.4 4 4 premature aging 0.00674763463091867 0.0852017316975137 1.96209800918836 0.357142857142857 4.4 4 4 abnormal renal tubule epithelium morphology 0.00674763463091867 0.0852017316975137 1.96209800918836 0.357142857142857 4.4 4 4 abnormal antigen presentation 0.0515393033512789 0.332565543673946 1.96209800918836 0.357142857142857 4.4 4 4 abnormal sagittal suture morphology 0.0515393033512789 0.332565543673946 1.96209800918836 0.357142857142857 4.4 4 4 split sternum 0.0515393033512789 0.332565543673946 1.96209800918836 0.357142857142857 4.4 4 4 abnormal viscerocranium morphology 0.0515393033512789 0.332565543673946 1.96209800918836 0.357142857142857 4.4 4 4 abnormal glucose tolerance 0.0515393033512789 0.332565543673946 1.96209800918836 0.357142857142857 4.4 4 4 spina bifida occulta 0.0515393033512789 0.332565543673946 1.96209800918836 0.357142857142857 4.4 4 4 pulmonary alveolar hemorrhage 0.0515393033512789 0.332565543673946 1.96209800918836 0.357142857142857 4.4 4 4 multiple persisting craniopharyngeal ducts 0.0515393033512789 0.332565543673946 1.96209800918836 0.357142857142857 4.4 4 4 decreased response to antigen 0.0515393033512789 0.332565543673946 1.96209800918836 0.357142857142857 4.4 4 4 abnormal myocardial trabeculae morphology 0.000716722633904242 0.0162817128021626 1.95337757359197 0.355555555555556 4.4 4 4 decreased thymus weight 0.00483565712793994 0.0673876588557457 1.94943931235489 0.354838709677419 4.4 4 4 inner cell mass degeneration 0.00483565712793994 0.0673876588557457 1.94943931235489 0.354838709677419 4.4 4 4 pericardial edema 4.31836627535591e-05 0.0017013998087411 1.93901450319791 0.352941176470588 4.4 4 4 abnormal direction of heart looping 0.00347414426546597 0.0520598425322084 1.93901450319791 0.352941176470588 4.4 4 4 decreased regulatory T cell number 0.00347414426546597 0.0520598425322084 1.93901450319791 0.352941176470588 4.4 4 4 abnormal vagus nerve morphology 0.0357534813014018 0.258913492684824 1.93901450319791 0.352941176470588 4.4 4 4 abnormal embryonic-extraembryonic boundary morphology 0.0357534813014018 0.258913492684824 1.93901450319791 0.352941176470588 4.4 4 4 pancytopenia 0.0357534813014018 0.258913492684824 1.93901450319791 0.352941176470588 4.4 4 4 enhanced behavioral response to cocaine 0.0357534813014018 0.258913492684824 1.93901450319791 0.352941176470588 4.4 4 4 lethality throughout fetal growth and development, complete penetrance 1.1755107020284e-11 1.77217143714887e-09 1.93731361328282 0.352631578947368 4.4 4 4 decreased birth body size 1.75712367264771e-07 1.32449852597308e-05 1.92767523709734 0.350877192982456 4.4 4 4 decreased myocardial infarction size 0.0250301863920714 0.202479963090334 1.92285604900459 0.35 4.4 4 4 absent placental labyrinth 0.0250301863920714 0.202479963090334 1.92285604900459 0.35 4.4 4 4 abnormal double-strand DNA break repair 0.00130379509346036 0.0256378679445268 1.91646782292817 0.348837209302326 4.4 4 4 embryonic lethality between implantation and placentation, complete penetrance 0.000943458620252209 0.0203190763452586 1.91091284373127 0.347826086956522 4.4 4 4 abnormal palatal shelf fusion at midline 0.0176442967126354 0.163384421977531 1.91091284373127 0.347826086956522 4.4 4 4 abnormal vertebral artery topology 0.0176442967126354 0.163384421977531 1.91091284373127 0.347826086956522 4.4 4 4 increased lymphocyte cell number 5.66116739715607e-05 0.00207090498535672 1.91091284373127 0.347826086956522 4.4 4 4 hydrops fetalis 4.13393050562103e-05 0.00164530434123717 1.90759528671091 0.347222222222222 4.4 4 4 abnormal immune system physiology 9.10225855577776e-08 7.42356333032694e-06 1.90513387343773 0.346774193548387 4.4 4 4 liver hypoplasia 0.000495903887178121 0.0119184629889428 1.9017257627518 0.346153846153846 4.4 4 4 abnormal leukocyte migration 0.000495903887178121 0.0119184629889428 1.9017257627518 0.346153846153846 4.4 4 4 decreased circulating glycerol level 0.0125052001623377 0.129139557286175 1.9017257627518 0.346153846153846 4.4 4 4 thrombocytosis 0.000261766836309 0.00719497243446009 1.89443945714738 0.344827586206897 4.4 4 4 lordosis 0.00890157602814187 0.10444655834907 1.89443945714738 0.344827586206897 4.4 4 4 polychromatophilia 0.00890157602814187 0.10444655834907 1.89443945714738 0.344827586206897 4.4 4 4 oxidative stress 6.3254083752073e-06 0.000321111292516901 1.89233452441722 0.344444444444444 4.4 4 4 abnormal osteoclast physiology 0.000138657571151721 0.0044949171542794 1.8885193338438 0.34375 4.4 4 4 embryonic lethality during organogenesis, complete penetrance 6.40958707189345e-29 1.5943847841335e-25 1.88361408882083 0.342857142857143 4.4 4 4 increased carcinoma incidence 0.00455654630039852 0.064400050694553 1.88361408882083 0.342857142857143 4.4 4 4 decreased bone marrow cell number 5.37382951758763e-05 0.00199513446641779 1.8814638444272 0.342465753424658 4.4 4 4 decreased hair follicle number 0.00327326266985723 0.0493469144925447 1.8794833561699 0.342105263157895 4.4 4 4 incomplete somite formation 0.00327326266985723 0.0493469144925447 1.8794833561699 0.342105263157895 4.4 4 4 abnormal cell morphology 5.26846963826162e-07 3.36033800645533e-05 1.8794833561699 0.342105263157895 4.4 4 4 abnormal somite development 2.86484999306233e-05 0.00119769989205757 1.87765328474228 0.341772151898734 4.4 4 4 hemopericardium 0.00235656729389951 0.040567205145848 1.87595712098009 0.341463414634146 4.4 4 4 increased bone trabecula number 0.00235656729389951 0.040567205145848 1.87595712098009 0.341463414634146 4.4 4 4 increased T cell number 1.1190748782707e-05 0.000530228335180641 1.87291173604344 0.340909090909091 4.4 4 4 decreased blood urea nitrogen level 0.00169984012049576 0.0315548679084568 1.87291173604344 0.340909090909091 4.4 4 4 pale yolk sac 2.69795496946707e-05 0.00114720734812809 1.85335522795624 0.337349397590361 4.4 4 4 decreased leukocyte cell number 9.98147556541897e-08 8.00932918354184e-06 1.84465856630263 0.335766423357664 4.4 4 4 abnormal nursing 0.0229751873653753 0.194004316560657 1.83129147524247 0.333333333333333 4.4 4 4 small lymph nodes 0.0229751873653753 0.194004316560657 1.83129147524247 0.333333333333333 4.4 4 4 increased susceptibility to parasitic infection 1.84525262224777e-05 0.000827038900511953 1.83129147524247 0.333333333333333 4.4 4 4 abnormal cytotoxic T cell physiology 0.00304076623691709 0.0479440223108105 1.83129147524247 0.333333333333333 4.4 4 4 abnormal skeleton physiology 0.00823430220866728 0.098712418043662 1.83129147524247 0.333333333333333 4.4 4 4 abnormal QRS complex 0.00823430220866728 0.098712418043662 1.83129147524247 0.333333333333333 4.4 4 4 increased osteoblast cell number 0.00823430220866728 0.098712418043662 1.83129147524247 0.333333333333333 4.4 4 4 disorganized myocardium 0.0115443531386287 0.126226718383907 1.83129147524247 0.333333333333333 4.4 4 4 abnormal eye pigmentation 0.0326803287663671 0.239095052371583 1.83129147524247 0.333333333333333 4.4 4 4 trunk curl 0.0326803287663671 0.239095052371583 1.83129147524247 0.333333333333333 4.4 4 4 abnormal embryonic/fetal subventricular zone morphology 0.0326803287663671 0.239095052371583 1.83129147524247 0.333333333333333 4.4 4 4 vascular ring 0.0326803287663671 0.239095052371583 1.83129147524247 0.333333333333333 4.4 4 4 decreased hepatocyte number 0.0678133238871959 0.387337871801148 1.83129147524247 0.333333333333333 4.4 4 4 abnormal seizure response to electrical stimulation 0.0678133238871959 0.387337871801148 1.83129147524247 0.333333333333333 4.4 4 4 absent egg cylinders 0.0678133238871959 0.387337871801148 1.83129147524247 0.333333333333333 4.4 4 4 placental labyrinth hypoplasia 0.0678133238871959 0.387337871801148 1.83129147524247 0.333333333333333 4.4 4 4 increased airway responsiveness 0.0678133238871959 0.387337871801148 1.83129147524247 0.333333333333333 4.4 4 4 abnormal respiratory system morphology 0.0678133238871959 0.387337871801148 1.83129147524247 0.333333333333333 4.4 4 4 delayed intramembranous bone ossification 0.0678133238871959 0.387337871801148 1.83129147524247 0.333333333333333 4.4 4 4 bicuspid aortic valve 0.0678133238871959 0.387337871801148 1.83129147524247 0.333333333333333 4.4 4 4 abnormal microglial cell activation 0.0678133238871959 0.387337871801148 1.83129147524247 0.333333333333333 4.4 4 4 heterochrony 0.0678133238871959 0.387337871801148 1.83129147524247 0.333333333333333 4.4 4 4 delayed bone ossification 8.89589583559323e-05 0.00305221253669492 1.83129147524247 0.333333333333333 4.4 4 4 abnormal inflammatory response 0.000122056730735236 0.00407538413025368 1.83129147524247 0.333333333333333 4.4 4 4 decreased spleen weight 0.000167584466161091 0.00515893999496114 1.83129147524247 0.333333333333333 4.4 4 4 distended abdomen 0.00114397681454491 0.0235177051750452 1.83129147524247 0.333333333333333 4.4 4 4 abnormal trophoblast layer morphology 0.00114397681454491 0.0235177051750452 1.83129147524247 0.333333333333333 4.4 4 4 abnormal trigeminal ganglion morphology 0.0162476343186688 0.153381367619312 1.83129147524247 0.333333333333333 4.4 4 4 abnormal eye muscle morphology 0.0162476343186688 0.153381367619312 1.83129147524247 0.333333333333333 4.4 4 4 abnormal megakaryocyte differentiation 0.0468385354715957 0.317901383316765 1.83129147524247 0.333333333333333 4.4 4 4 right pulmonary isomerism 0.0468385354715957 0.317901383316765 1.83129147524247 0.333333333333333 4.4 4 4 abnormal iron level 0.0468385354715957 0.317901383316765 1.83129147524247 0.333333333333333 4.4 4 4 acidosis 0.0468385354715957 0.317901383316765 1.83129147524247 0.333333333333333 4.4 4 4 absent inner cell mass 0.0468385354715957 0.317901383316765 1.83129147524247 0.333333333333333 4.4 4 4 abnormal neutrophil morphology 0.0468385354715957 0.317901383316765 1.83129147524247 0.333333333333333 4.4 4 4 increased susceptibility to autoimmune disorder 0.0468385354715957 0.317901383316765 1.83129147524247 0.333333333333333 4.4 4 4 abnormal glycogen homeostasis 0.0468385354715957 0.317901383316765 1.83129147524247 0.333333333333333 4.4 4 4 impaired leukocyte tethering or rolling 0.0468385354715957 0.317901383316765 1.83129147524247 0.333333333333333 4.4 4 4 incomplete embryo turning 0.000600530141864892 0.0138316548878604 1.83129147524247 0.333333333333333 4.4 4 4 decreased susceptibility to induced arthritis 0.000600530141864892 0.0138316548878604 1.83129147524247 0.333333333333333 4.4 4 4 impaired natural killer cell mediated cytotoxicity 0.000600530141864892 0.0138316548878604 1.83129147524247 0.333333333333333 4.4 4 4 embryonic lethality between implantation and somite formation, complete penetrance 4.32387382879427e-12 7.68259724937553e-10 1.81634215707723 0.330612244897959 4.4 4 4 abnormal coat/hair pigmentation 2.64332427961992e-06 0.00014943793512624 1.81494065849923 0.330357142857143 4.4 4 4 decreased cell proliferation 2.0188792091005e-09 2.13700512027127e-07 1.81149372956417 0.32972972972973 4.4 4 4 decreased hematocrit 1.10954352131152e-07 8.49227541311507e-06 1.80620529065011 0.328767123287671 4.4 4 4 internal hemorrhage 0.000293451677481592 0.00772445553159218 1.80395876665676 0.328358208955224 4.4 4 4 decreased white adipose tissue amount 0.000293451677481592 0.00772445553159218 1.80395876665676 0.328358208955224 4.4 4 4 decreased circulating total protein level 0.00105611756960213 0.022169556577091 1.7979952666017 0.327272727272727 4.4 4 4 decreased hemoglobin content 2.60203659660579e-07 1.79793500946025e-05 1.79232782683306 0.326241134751773 4.4 4 4 failure to gastrulate 0.00279524091711701 0.0448493403422615 1.79148079099807 0.326086956521739 4.4 4 4 pallor 1.10442942310484e-08 1.03670497734841e-06 1.78943338437979 0.325714285714286 4.4 4 4 increased erythroid progenitor cell number 0.00751991075047991 0.0919202849720824 1.78179711104673 0.324324324324324 4.4 4 4 increased trabecular bone volume 0.00751991075047991 0.0919202849720824 1.78179711104673 0.324324324324324 4.4 4 4 increased leukocyte cell number 2.40717432351269e-07 1.68671721964446e-05 1.78077308971854 0.324137931034483 4.4 4 4 abnormal oocyte morphology 0.0105108994858505 0.118307070004765 1.77742996126475 0.323529411764706 4.4 4 4 hemorrhage 6.4255273709405e-11 8.41236807116553e-09 1.77674236746929 0.323404255319149 4.4 4 4 abnormal T cell proliferation 0.0147389702865757 0.1412839637297 1.77221755668626 0.32258064516129 4.4 4 4 abnormal spleen germinal center morphology 0.020747634170761 0.183664555159317 1.76588820826953 0.321428571428571 4.4 4 4 failure of blastocyst to hatch from the zona pellucida 0.020747634170761 0.183664555159317 1.76588820826953 0.321428571428571 4.4 4 4 abnormal mitotic spindle morphology 0.020747634170761 0.183664555159317 1.76588820826953 0.321428571428571 4.4 4 4 decreased embryo size 5.21129044808662e-20 2.59261699792309e-17 1.75849955467844 0.320083682008368 4.4 4 4 abnormal thyroid gland morphology 0.0293431735177206 0.220517051738157 1.75803981623277 0.32 4.4 4 4 abnormal egg cylinder morphology 0.0293431735177206 0.220517051738157 1.75803981623277 0.32 4.4 4 4 abnormal keratinocyte physiology 0.0293431735177206 0.220517051738157 1.75803981623277 0.32 4.4 4 4 embryonic growth arrest 3.15535423423875e-10 3.56770166257677e-08 1.75132241518821 0.318777292576419 4.4 4 4 muscular atrophy 0.00489638718822329 0.0676653507261413 1.74805095364054 0.318181818181818 4.4 4 4 abnormal facial nerve morphology 0.0417424406092324 0.288829822017985 1.74805095364054 0.318181818181818 4.4 4 4 abnormal retinal layer morphology 0.0417424406092324 0.288829822017985 1.74805095364054 0.318181818181818 4.4 4 4 abnormal limb posture 0.0417424406092324 0.288829822017985 1.74805095364054 0.318181818181818 4.4 4 4 decreased circulating estradiol level 0.0417424406092324 0.288829822017985 1.74805095364054 0.318181818181818 4.4 4 4 pulmonary vascular congestion 0.0417424406092324 0.288829822017985 1.74805095364054 0.318181818181818 4.4 4 4 abnormal developmental patterning 0.000164922690863908 0.00512806491904964 1.74196018376723 0.317073170731707 4.4 4 4 Leydig cell hyperplasia 0.00680537036169167 0.0854967614884244 1.74196018376723 0.317073170731707 4.4 4 4 abnormal cell differentiation 0.00680537036169167 0.0854967614884244 1.74196018376723 0.317073170731707 4.4 4 4 prenatal lethality, complete penetrance 7.73741806267645e-12 1.28312182872718e-09 1.73906816353961 0.316546762589928 4.4 4 4 abnormal placenta morphology 0.000225916483902865 0.00642035563779448 1.73856785624285 0.316455696202532 4.4 4 4 altered susceptibility to infection 0.0598249926283085 0.370646747603779 1.7349077133876 0.315789473684211 4.4 4 4 abnormal optic vesicle formation 0.0598249926283085 0.370646747603779 1.7349077133876 0.315789473684211 4.4 4 4 Leydig cell hypoplasia 0.0598249926283085 0.370646747603779 1.7349077133876 0.315789473684211 4.4 4 4 decreased circulating magnesium level 0.0598249926283085 0.370646747603779 1.7349077133876 0.315789473684211 4.4 4 4 embryonic lethality between implantation and somite formation, incomplete penetrance 0.0598249926283085 0.370646747603779 1.7349077133876 0.315789473684211 4.4 4 4 seminiferous tubule degeneration 0.000424646807457309 0.0105630893355006 1.73094673687302 0.315068493150685 4.4 4 4 astrocytosis 0.000424646807457309 0.0105630893355006 1.73094673687302 0.315068493150685 4.4 4 4 abnormal apoptosis 0.00230998295201496 0.0401823957562042 1.72955305995122 0.314814814814815 4.4 4 4 abnormal neuronal precursor proliferation 0.00230998295201496 0.0401823957562042 1.72955305995122 0.314814814814815 4.4 4 4 holoprosencephaly 0.0132399780291827 0.129139557286175 1.72664624808576 0.314285714285714 4.4 4 4 abnormal hippocampus pyramidal cell morphology 0.0132399780291827 0.129139557286175 1.72664624808576 0.314285714285714 4.4 4 4 edema 1.05673569704122e-07 8.34485729012708e-06 1.72482104063535 0.313953488372093 4.4 4 4 increased mean corpuscular hemoglobin 5.34474675305186e-05 0.00199513446641779 1.72030411310656 0.313131313131313 4.4 4 4 abnormal lymph node morphology 0.00441512299052135 0.0625790224439992 1.71683575803982 0.3125 4.4 4 4 abnormal osteoclast morphology 0.00441512299052135 0.0625790224439992 1.71683575803982 0.3125 4.4 4 4 polydipsia 0.0185479777522701 0.169625348010191 1.71683575803982 0.3125 4.4 4 4 failure of primitive streak formation 0.0185479777522701 0.169625348010191 1.71683575803982 0.3125 4.4 4 4 abnormal spongiotrophoblast layer morphology 0.0185479777522701 0.169625348010191 1.71683575803982 0.3125 4.4 4 4 vasculature congestion 0.0865895799566007 0.455855196067818 1.71683575803982 0.3125 4.4 4 4 intraventricular hemorrhage 0.0865895799566007 0.455855196067818 1.71683575803982 0.3125 4.4 4 4 dystonia 0.0865895799566007 0.455855196067818 1.71683575803982 0.3125 4.4 4 4 decreased creatinine clearance 0.0865895799566007 0.455855196067818 1.71683575803982 0.3125 4.4 4 4 abnormal pulmonary alveolus wall morphology 0.0865895799566007 0.455855196067818 1.71683575803982 0.3125 4.4 4 4 embryonic lethality between somite formation and embryo turning, incomplete penetrance 0.0865895799566007 0.455855196067818 1.71683575803982 0.3125 4.4 4 4 abnormal spermiogenesis 0.00208303806480174 0.0367486325262009 1.70499551143265 0.310344827586207 4.4 4 4 abnormal outer ear morphology 0.0260783603349396 0.208079620012462 1.70499551143265 0.310344827586207 4.4 4 4 blood in lymph vessels 0.0260783603349396 0.208079620012462 1.70499551143265 0.310344827586207 4.4 4 4 abnormal embryo size 2.36662756374591e-05 0.00103280457277508 1.701642521243 0.309734513274336 4.4 4 4 abnormal head morphology 0.00287092272835752 0.0454867534190403 1.69810664067938 0.309090909090909 4.4 4 4 abnormal rostral-caudal axis patterning 0.00287092272835752 0.0454867534190403 1.69810664067938 0.309090909090909 4.4 4 4 abnormal T-helper 2 physiology 0.00287092272835752 0.0454867534190403 1.69810664067938 0.309090909090909 4.4 4 4 ventricular septal defect 4.17233144625256e-06 0.000218634909134195 1.69663769029817 0.308823529411765 4.4 4 4 double outlet right ventricle 4.38977972545951e-05 0.00170618391673133 1.6943724864393 0.308411214953271 4.4 4 4 small liver 0.000475673790429908 0.0115437907677502 1.69042290022382 0.307692307692308 4.4 4 4 small spleen 0.000167989603856021 0.00515893999496114 1.69042290022382 0.307692307692308 4.4 4 4 abnormal placenta vasculature 0.00396132702947203 0.0571234839757199 1.69042290022382 0.307692307692308 4.4 4 4 heart inflammation 0.0368267172312242 0.261158891691591 1.69042290022382 0.307692307692308 4.4 4 4 pulmonary edema 0.0368267172312242 0.261158891691591 1.69042290022382 0.307692307692308 4.4 4 4 abnormal nerve conduction 0.0368267172312242 0.261158891691591 1.69042290022382 0.307692307692308 4.4 4 4 prenatal lethality 0.00187093260593846 0.0342201827740582 1.68360667885195 0.306451612903226 4.4 4 4 decreased circulating creatinine level 0.0054728042317633 0.0735870298730335 1.68179829359002 0.306122448979592 4.4 4 4 abnormal pharyngeal arch morphology 0.0164729645095164 0.155214012187204 1.6786838523056 0.305555555555556 4.4 4 4 abnormal spermatogenesis 1.99341310184673e-07 1.45841620318934e-05 1.67204873826486 0.304347826086957 4.4 4 4 atrial septal defect 0.00757169965051581 0.0923264847091083 1.67204873826486 0.304347826086957 4.4 4 4 abnormal cranial nerve morphology 0.0522853785639936 0.33563839787854 1.67204873826486 0.304347826086957 4.4 4 4 abnormal cardiovascular development 0.0522853785639936 0.33563839787854 1.67204873826486 0.304347826086957 4.4 4 4 abnormal Wolffian duct morphology 0.0522853785639936 0.33563839787854 1.67204873826486 0.304347826086957 4.4 4 4 dilated heart 0.0522853785639936 0.33563839787854 1.67204873826486 0.304347826086957 4.4 4 4 abnormal sternum morphology 0.00122173660081612 0.0245783162729017 1.67204873826486 0.304347826086957 4.4 4 4 increased neutrophil cell number 4.17493796336654e-06 0.000218634909134195 1.6671067222897 0.303448275862069 4.4 4 4 abnormal ovarian folliculogenesis 0.0230321845103582 0.194004316560657 1.66481043203861 0.303030303030303 4.4 4 4 decreased brown adipose tissue amount 0.0230321845103582 0.194004316560657 1.66481043203861 0.303030303030303 4.4 4 4 abnormal homeostasis 0.0104921987670708 0.118307070004765 1.66093877987108 0.302325581395349 4.4 4 4 impaired macrophage phagocytosis 0.0104921987670708 0.118307070004765 1.66093877987108 0.302325581395349 4.4 4 4 abnormal coat/ hair morphology 0.00487712733295125 0.0675869317031545 1.65852812852148 0.30188679245283 4.4 4 4 increased circulating bilirubin level 0.00487712733295125 0.0675869317031545 1.65852812852148 0.30188679245283 4.4 4 4 decreased percent body fat/body weight 0.00109309968857594 0.022659045627772 1.65568818309593 0.301369863013699 4.4 4 4 preweaning lethality, complete penetrance 2.9911901728131e-24 2.12588158710645e-21 1.64816232771822 0.3 4.4 4 4 embryonic lethality during organogenesis, incomplete penetrance 1.57216800235701e-08 1.44843255772706e-06 1.64816232771822 0.3 4.4 4 4 absent mesoderm 0.00315443314999305 0.0487567372248807 1.64816232771822 0.3 4.4 4 4 arrested T cell differentiation 0.03230722056193 0.237763938307103 1.64816232771822 0.3 4.4 4 4 abnormal microglial cell physiology 0.03230722056193 0.237763938307103 1.64816232771822 0.3 4.4 4 4 abnormal optic cup morphology 0.03230722056193 0.237763938307103 1.64816232771822 0.3 4.4 4 4 abnormal brain vasculature morphology 0.03230722056193 0.237763938307103 1.64816232771822 0.3 4.4 4 4 abnormal fat pad morphology 0.03230722056193 0.237763938307103 1.64816232771822 0.3 4.4 4 4 abnormal cellular respiration 0.03230722056193 0.237763938307103 1.64816232771822 0.3 4.4 4 4 abnormal pericardium morphology 0.0747370524438385 0.415485018346702 1.64816232771822 0.3 4.4 4 4 abnormal cell proliferation 0.0747370524438385 0.415485018346702 1.64816232771822 0.3 4.4 4 4 abnormal vascular regression 0.0747370524438385 0.415485018346702 1.64816232771822 0.3 4.4 4 4 abnormal circulating enzyme level 0.0747370524438385 0.415485018346702 1.64816232771822 0.3 4.4 4 4 spleen atrophy 0.0747370524438385 0.415485018346702 1.64816232771822 0.3 4.4 4 4 abnormal interventricular septum morphology 0.00672586066411805 0.0852017316975137 1.64816232771822 0.3 4.4 4 4 hepatic necrosis 0.00928644549037174 0.108450859893426 1.6364732331954 0.297872340425532 4.4 4 4 increased cellular sensitivity to gamma-irradiation 0.00928644549037174 0.108450859893426 1.6364732331954 0.297872340425532 4.4 4 4 abnormal heart development 3.68084909936103e-06 0.000196905637304528 1.63425378486828 0.29746835443038 4.4 4 4 abnormal branching of the mammary ductal tree 0.0202607949460318 0.180317450548316 1.6333140184595 0.297297297297297 4.4 4 4 skin inflammation 0.0202607949460318 0.180317450548316 1.6333140184595 0.297297297297297 4.4 4 4 decreased caudal vertebrae number 0.00280364720531524 0.0448493403422615 1.63099397013783 0.296875 4.4 4 4 abnormal tooth morphology 0.00280364720531524 0.0448493403422615 1.63099397013783 0.296875 4.4 4 4 increased cell proliferation 0.0059580302301876 0.0792545465111853 1.62781464465997 0.296296296296296 4.4 4 4 abnormal maxilla morphology 0.0059580302301876 0.0792545465111853 1.62781464465997 0.296296296296296 4.4 4 4 abnormal small intestine morphology 0.0059580302301876 0.0792545465111853 1.62781464465997 0.296296296296296 4.4 4 4 abnormal type II pneumocyte morphology 0.045491594247037 0.313029988076085 1.62781464465997 0.296296296296296 4.4 4 4 teratozoospermia 0.000568397415909858 0.0132759490335753 1.62319017123764 0.295454545454545 4.4 4 4 osteoporosis 0.0128388294291682 0.129139557286175 1.62319017123764 0.295454545454545 4.4 4 4 renal interstitial fibrosis 0.0128388294291682 0.129139557286175 1.62319017123764 0.295454545454545 4.4 4 4 increased osteoclast cell number 0.0038415720816098 0.0555576194942115 1.62114327316547 0.295081967213115 4.4 4 4 abnormal NK cell physiology 0.0038415720816098 0.0555576194942115 1.62114327316547 0.295081967213115 4.4 4 4 increased rib number 0.00118490404028096 0.0241594163950728 1.61998861271449 0.294871794871795 4.4 4 4 small lung 0.00819859223444111 0.098712418043662 1.61584541933159 0.294117647058824 4.4 4 4 abnormal thrombosis 0.00819859223444111 0.098712418043662 1.61584541933159 0.294117647058824 4.4 4 4 enlarged liver sinusoidal spaces 0.0282493866039032 0.215840886740304 1.61584541933159 0.294117647058824 4.4 4 4 abnormal endoderm development 0.0282493866039032 0.215840886740304 1.61584541933159 0.294117647058824 4.4 4 4 abnormal adipose tissue morphology 0.1077712877296 0.512509629519955 1.61584541933159 0.294117647058824 4.4 4 4 abnormal bone marrow cavity morphology 0.1077712877296 0.512509629519955 1.61584541933159 0.294117647058824 4.4 4 4 abnormal interatrial septum morphology 0.1077712877296 0.512509629519955 1.61584541933159 0.294117647058824 4.4 4 4 distended urinary bladder 0.1077712877296 0.512509629519955 1.61584541933159 0.294117647058824 4.4 4 4 increased incidence of corneal inflammation 0.1077712877296 0.512509629519955 1.61584541933159 0.294117647058824 4.4 4 4 abnormal dorsal-ventral axis patterning 0.1077712877296 0.512509629519955 1.61584541933159 0.294117647058824 4.4 4 4 abnormal testis development 0.1077712877296 0.512509629519955 1.61584541933159 0.294117647058824 4.4 4 4 coloboma 0.1077712877296 0.512509629519955 1.61584541933159 0.294117647058824 4.4 4 4 increased circulating magnesium level 0.1077712877296 0.512509629519955 1.61584541933159 0.294117647058824 4.4 4 4 increased hepatoma incidence 0.1077712877296 0.512509629519955 1.61584541933159 0.294117647058824 4.4 4 4 abnormal survival 0.1077712877296 0.512509629519955 1.61584541933159 0.294117647058824 4.4 4 4 increased trabecular bone mass 0.1077712877296 0.512509629519955 1.61584541933159 0.294117647058824 4.4 4 4 abnormal electroretinogram waveform feature 0.1077712877296 0.512509629519955 1.61584541933159 0.294117647058824 4.4 4 4 abnormal ductus venosus valve morphology 0.1077712877296 0.512509629519955 1.61584541933159 0.294117647058824 4.4 4 4 abnormal renal glomerulus morphology 0.000160450023250814 0.00502037022435722 1.61288056535117 0.293577981651376 4.4 4 4 glomerulosclerosis 0.00526663289088054 0.0716611578235192 1.61027353857528 0.293103448275862 4.4 4 4 decreased circulating serum albumin level 0.000331278153056741 0.00862884194480253 1.60931675097066 0.292929292929293 4.4 4 4 abnormal mammary gland development 0.0177762668358533 0.163772087978463 1.60796324655436 0.292682926829268 4.4 4 4 small heart 0.0112922841667807 0.123742541254921 1.60238004083716 0.291666666666667 4.4 4 4 vertebral transformation 0.0112922841667807 0.123742541254921 1.60238004083716 0.291666666666667 4.4 4 4 abnormal adrenal gland morphology 0.0643542808222482 0.375337100926946 1.60238004083716 0.291666666666667 4.4 4 4 abnormal body weight 0.0643542808222482 0.375337100926946 1.60238004083716 0.291666666666667 4.4 4 4 abnormal tumor morphology 0.0643542808222482 0.375337100926946 1.60238004083716 0.291666666666667 4.4 4 4 abnormal cellular extravasation 0.0643542808222482 0.375337100926946 1.60238004083716 0.291666666666667 4.4 4 4 abnormal forebrain development 0.00220234157749064 0.0385797512254082 1.60238004083716 0.291666666666667 4.4 4 4 abnormal visceral yolk sac morphology 0.00143143333666363 0.0272849840992398 1.59948242774342 0.291139240506329 4.4 4 4 abnormal platelet physiology 0.007224535871964 0.089618030555165 1.59821801475707 0.290909090909091 4.4 4 4 decreased neutrophil cell number 0.000126985968062906 0.0042117012740864 1.59651051687805 0.290598290598291 4.4 4 4 increased bone marrow cell number 0.0246530105205128 0.200079489950328 1.5903320706053 0.289473684210526 4.4 4 4 persistence of hyaloid vascular system 0.0246530105205128 0.200079489950328 1.5903320706053 0.289473684210526 4.4 4 4 decreased neuron apoptosis 0.0246530105205128 0.200079489950328 1.5903320706053 0.289473684210526 4.4 4 4 abnormal cell migration 0.0155691684897067 0.147536406164363 1.58711927854347 0.288888888888889 4.4 4 4 abnormal snout morphology 0.0099164024526718 0.112634936534343 1.58477146895983 0.288461538461538 4.4 4 4 abnormal eye morphology 4.34327187357025e-05 0.0017013998087411 1.58097105776328 0.287769784172662 4.4 4 4 abnormal testis morphology 0.000205502788368338 0.00590969001232649 1.5765030960783 0.28695652173913 4.4 4 4 abnormal vitelline vasculature morphology 0.000205502788368338 0.00590969001232649 1.5765030960783 0.28695652173913 4.4 4 4 prenatal lethality, incomplete penetrance 2.98147790506239e-09 2.96657051553708e-07 1.57226011525752 0.286184210526316 4.4 4 4 embryonic lethality between somite formation and embryo turning, complete penetrance 0.00360637749075149 0.0532010600146933 1.56967840735069 0.285714285714286 4.4 4 4 abnormal pancreas morphology 0.0214895929617652 0.189558023022663 1.56967840735069 0.285714285714286 4.4 4 4 abnormal embryonic epiblast morphology 0.0342531500337913 0.249867186830076 1.56967840735069 0.285714285714286 4.4 4 4 increased red blood cell distribution width 0.0342531500337913 0.249867186830076 1.56967840735069 0.285714285714286 4.4 4 4 abnormal ovulation 0.0553891782775473 0.350141247688434 1.56967840735069 0.285714285714286 4.4 4 4 hypoxia 0.0553891782775473 0.350141247688434 1.56967840735069 0.285714285714286 4.4 4 4 abnormal hematopoietic system physiology 0.091559741914827 0.476973524634831 1.56967840735069 0.285714285714286 4.4 4 4 left pulmonary isomerism 0.091559741914827 0.476973524634831 1.56967840735069 0.285714285714286 4.4 4 4 increased muscle cell glucose uptake 0.091559741914827 0.476973524634831 1.56967840735069 0.285714285714286 4.4 4 4 lethality throughout fetal growth and development, incomplete penetrance 5.77291101788976e-06 0.000299169086604183 1.56529383079384 0.284916201117318 4.4 4 4 increased bone mineral content 0.000373915047134912 0.00953962748459583 1.56247804768394 0.284403669724771 4.4 4 4 decreased birth weight 0.00087352052544959 0.019060371114525 1.56141694204884 0.284210526315789 4.4 4 4 abnormal angiogenesis 0.00317247475822356 0.0487567372248807 1.55907247216589 0.283783783783784 4.4 4 4 abnormal eating behavior 0.00762327754797089 0.0927281315431667 1.5565977539561 0.283333333333333 4.4 4 4 perinatal lethality, incomplete penetrance 5.12996887870477e-07 3.31449287942289e-05 1.5557874479936 0.283185840707965 4.4 4 4 abnormal mesoderm development 0.0119055899999299 0.129042070260679 1.55487012048889 0.283018867924528 4.4 4 4 abnormal placenta development 0.0119055899999299 0.129042070260679 1.55487012048889 0.283018867924528 4.4 4 4 atrioventricular septal defect 0.0119055899999299 0.129042070260679 1.55487012048889 0.283018867924528 4.4 4 4 abnormal locomotor behavior 0.00118020823937976 0.0241594163950728 1.55261668553166 0.282608695652174 4.4 4 4 premature death 2.05235389746135e-22 1.27630757998378e-19 1.55053598774885 0.282229965156794 4.4 4 4 increased embryonic tissue cell apoptosis 0.00278890837810644 0.0448493403422615 1.54955432520517 0.282051282051282 4.4 4 4 small lens 0.0296968591098476 0.222838422430606 1.54955432520517 0.282051282051282 4.4 4 4 abnormal ovary morphology 0.00430689572626066 0.0613948602812229 1.54757026076829 0.28169014084507 4.4 4 4 neonatal lethality 0.0476905924109709 0.322365077777962 1.54515218223583 0.28125 4.4 4 4 increased fatty acid level 0.0476905924109709 0.322365077777962 1.54515218223583 0.28125 4.4 4 4 embryonic lethality before implantation, complete penetrance 0.000227132179347101 0.00642035563779448 1.53828483920368 0.28 4.4 4 4 abnormal liver physiology 0.000915162130415977 0.0198817973747576 1.53828483920368 0.28 4.4 4 4 abnormal primitive streak morphology 0.0779697114406757 0.42037471168297 1.53828483920368 0.28 4.4 4 4 abnormal feces composition 0.0779697114406757 0.42037471168297 1.53828483920368 0.28 4.4 4 4 decreased acute inflammation 0.0779697114406757 0.42037471168297 1.53828483920368 0.28 4.4 4 4 abnormal embryo development 0.000131791837290469 0.00434214828158995 1.53505314836501 0.279411764705882 4.4 4 4 decreased mean corpuscular hemoglobin 0.00584579121393028 0.0783903269253454 1.53505314836501 0.279411764705882 4.4 4 4 abnormal hepatocyte morphology 0.000527332867457608 0.0125525407445053 1.53432529006802 0.279279279279279 4.4 4 4 abnormal vasculogenesis 0.0257466487790662 0.207264688795881 1.53317425834253 0.27906976744186 4.4 4 4 preweaning lethality, incomplete penetrance 6.9674956866504e-11 8.88802334386814e-09 1.53129996218319 0.278728606356968 4.4 4 4 respiratory failure 6.75972347544114e-05 0.00243692929639998 1.52809752238776 0.278145695364238 4.4 4 4 thin ventricular wall 0.00188930621623449 0.0342327377049549 1.52607622936873 0.277777777777778 4.4 4 4 cochlear outer hair cell degeneration 0.00511633962963375 0.0699279935643624 1.52607622936873 0.277777777777778 4.4 4 4 abnormal cell adhesion 0.0141931129882923 0.136314164318059 1.52607622936873 0.277777777777778 4.4 4 4 impaired wound healing 0.0410916829277433 0.286719666992318 1.52607622936873 0.277777777777778 4.4 4 4 lowered ear position 0.131206961674987 0.542952934942497 1.52607622936873 0.277777777777778 4.4 4 4 abnormal mitral valve morphology 0.131206961674987 0.542952934942497 1.52607622936873 0.277777777777778 4.4 4 4 abnormal mammary gland morphology 0.131206961674987 0.542952934942497 1.52607622936873 0.277777777777778 4.4 4 4 thick dermal layer 0.131206961674987 0.542952934942497 1.52607622936873 0.277777777777778 4.4 4 4 abnormal redox activity 0.131206961674987 0.542952934942497 1.52607622936873 0.277777777777778 4.4 4 4 decreased cellular sensitivity to gamma-irradiation 0.131206961674987 0.542952934942497 1.52607622936873 0.277777777777778 4.4 4 4 long tibia 0.131206961674987 0.542952934942497 1.52607622936873 0.277777777777778 4.4 4 4 darkened coat color 0.131206961674987 0.542952934942497 1.52607622936873 0.277777777777778 4.4 4 4 primary atelectasis 0.131206961674987 0.542952934942497 1.52607622936873 0.277777777777778 4.4 4 4 abnormal aerobic respiration 0.131206961674987 0.542952934942497 1.52607622936873 0.277777777777778 4.4 4 4 increased adipocyte glucose uptake 0.131206961674987 0.542952934942497 1.52607622936873 0.277777777777778 4.4 4 4 abnormal neural tube morphology 3.93656315455401e-05 0.00157938723337953 1.52607622936873 0.277777777777778 4.4 4 4 abnormal heart morphology 1.17920887994709e-06 7.15434655821558e-05 1.52211239500673 0.277056277056277 4.4 4 4 perinatal lethality, complete penetrance 3.03559307173598e-06 0.00016415299491181 1.52177742308881 0.276995305164319 4.4 4 4 decreased monocyte cell number 0.00793248852298119 0.0962539765898327 1.52138061020144 0.276923076923077 4.4 4 4 dermatitis 0.0123576327722448 0.129139557286175 1.51555156571791 0.275862068965517 4.4 4 4 abnormal embryonic neuroepithelium morphology 0.0123576327722448 0.129139557286175 1.51555156571791 0.275862068965517 4.4 4 4 abnormal circulating glucose level 0.0665552041604456 0.385911585895358 1.51555156571791 0.275862068965517 4.4 4 4 decreased bone strength 0.0665552041604456 0.385911585895358 1.51555156571791 0.275862068965517 4.4 4 4 abnormal retinal pigmentation 0.00254508928281877 0.0424893261141724 1.51555156571791 0.275862068965517 4.4 4 4 increased lung adenocarcinoma incidence 0.0193669963653679 0.173605057509379 1.50812239137615 0.274509803921569 4.4 4 4 cochlear inner hair cell degeneration 0.0193669963653679 0.173605057509379 1.50812239137615 0.274509803921569 4.4 4 4 decreased macrophage cell number 0.0305870810352781 0.228828162632343 1.49832938883475 0.272727272727273 4.4 4 4 lethality, incomplete penetrance 0.0305870810352781 0.228828162632343 1.49832938883475 0.272727272727273 4.4 4 4 decreased systemic arterial blood pressure 0.0569374953737006 0.357656615510304 1.49832938883475 0.272727272727273 4.4 4 4 increased cardiomyocyte apoptosis 0.0569374953737006 0.357656615510304 1.49832938883475 0.272727272727273 4.4 4 4 single kidney 0.0569374953737006 0.357656615510304 1.49832938883475 0.272727272727273 4.4 4 4 abnormal tail movements 0.110241229904425 0.512509629519955 1.49832938883475 0.272727272727273 4.4 4 4 intracerebral hemorrhage 0.110241229904425 0.512509629519955 1.49832938883475 0.272727272727273 4.4 4 4 testis hypoplasia 0.110241229904425 0.512509629519955 1.49832938883475 0.272727272727273 4.4 4 4 increased skin papilloma incidence 0.110241229904425 0.512509629519955 1.49832938883475 0.272727272727273 4.4 4 4 aphakia 0.110241229904425 0.512509629519955 1.49832938883475 0.272727272727273 4.4 4 4 abnormal circulating lipid level 0.110241229904425 0.512509629519955 1.49832938883475 0.272727272727273 4.4 4 4 abnormal basement membrane morphology 0.110241229904425 0.512509629519955 1.49832938883475 0.272727272727273 4.4 4 4 failure of palatal shelf elevation 0.110241229904425 0.512509629519955 1.49832938883475 0.272727272727273 4.4 4 4 embryonic lethality before implantation, incomplete penetrance 0.110241229904425 0.512509629519955 1.49832938883475 0.272727272727273 4.4 4 4 embryonic lethality, complete penetrance 3.53240687530851e-08 3.1381650365464e-06 1.49832938883475 0.272727272727273 4.4 4 4 increased circulating alkaline phosphatase level 8.49004737202554e-05 0.00293319344971021 1.49216342427164 0.271604938271605 4.4 4 4 increased neuron apoptosis 0.00460984510700235 0.0649687801907555 1.49216342427164 0.271604938271605 4.4 4 4 reduced female fertility 2.95440278314925e-06 0.000161518174133709 1.49187107250356 0.271551724137931 4.4 4 4 increased white adipose tissue amount 0.0488068266246735 0.328126976294258 1.48483092587227 0.27027027027027 4.4 4 4 decreased circulating chloride level 0.0488068266246735 0.328126976294258 1.48483092587227 0.27027027027027 4.4 4 4 enlarged liver 0.00200625543265049 0.0357746264424235 1.4833460949464 0.27 4.4 4 4 decreased rib number 0.00351544590574143 0.0525205506938848 1.48149422716245 0.269662921348315 4.4 4 4 limb grasping 4.45693995785144e-05 0.00171885862715588 1.47912003769584 0.269230769230769 4.4 4 4 kinked neural tube 0.022848794122677 0.194004316560657 1.47912003769584 0.269230769230769 4.4 4 4 small seminal vesicle 0.0931276566757368 0.481611322205603 1.47912003769584 0.269230769230769 4.4 4 4 no spontaneous movement 0.0931276566757368 0.481611322205603 1.47912003769584 0.269230769230769 4.4 4 4 sparse hair 0.00540164507896412 0.0728270576364404 1.4739663093415 0.268292682926829 4.4 4 4 liver fibrosis 0.0419118181737154 0.289599021408659 1.4739663093415 0.268292682926829 4.4 4 4 small placenta 0.0360481401427586 0.260592751774422 1.46503318019398 0.266666666666667 4.4 4 4 abnormal hair cycle 0.0790090163780876 0.421296737921743 1.46503318019398 0.266666666666667 4.4 4 4 abnormal neurocranium morphology 0.00832370035950481 0.0995442530974433 1.46503318019398 0.266666666666667 4.4 4 4 abnormal placenta labyrinth morphology 0.007241497142347 0.089618030555165 1.460396999244 0.265822784810127 4.4 4 4 decreased circulating LDL cholesterol level 0.0148405379693587 0.14198399307223 1.45931039433384 0.265625 4.4 4 4 organ of Corti degeneration 0.0310489215842438 0.2306414653387 1.45755852111135 0.26530612244898 4.4 4 4 increased circulating LDL cholesterol level 0.0310489215842438 0.2306414653387 1.45755852111135 0.26530612244898 4.4 4 4 abnormal respiratory system physiology 0.0310489215842438 0.2306414653387 1.45755852111135 0.26530612244898 4.4 4 4 postnatal lethality 0.000155881944218636 0.00493957116234213 1.45620767910847 0.265060240963855 4.4 4 4 cataract 0.00119497389018891 0.0242652861375096 1.45292546796097 0.264462809917355 4.4 4 4 azoospermia 0.000235038322539497 0.0066063031335254 1.4512121124563 0.264150943396226 4.4 4 4 abnormal reproductive system physiology 0.0574331895190165 0.358957434493853 1.445756427823 0.263157894736842 4.4 4 4 decreased total retina thickness 0.0574331895190165 0.358957434493853 1.445756427823 0.263157894736842 4.4 4 4 kyphoscoliosis 0.1567005220488 0.545958806155995 1.445756427823 0.263157894736842 4.4 4 4 abnormal triglyceride level 0.1567005220488 0.545958806155995 1.445756427823 0.263157894736842 4.4 4 4 small superior vagus ganglion 0.1567005220488 0.545958806155995 1.445756427823 0.263157894736842 4.4 4 4 decreased tumor incidence 0.1567005220488 0.545958806155995 1.445756427823 0.263157894736842 4.4 4 4 decreased germ cell number 0.1567005220488 0.545958806155995 1.445756427823 0.263157894736842 4.4 4 4 oliguria 0.1567005220488 0.545958806155995 1.445756427823 0.263157894736842 4.4 4 4 increased left ventricle weight 0.1567005220488 0.545958806155995 1.445756427823 0.263157894736842 4.4 4 4 abnormal blastocyst morphology 0.1567005220488 0.545958806155995 1.445756427823 0.263157894736842 4.4 4 4 increased liver cholesterol level 0.1567005220488 0.545958806155995 1.445756427823 0.263157894736842 4.4 4 4 increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 0.1567005220488 0.545958806155995 1.445756427823 0.263157894736842 4.4 4 4 right-sided stomach 0.1567005220488 0.545958806155995 1.445756427823 0.263157894736842 4.4 4 4 decreased brain weight 0.0231195832214082 0.194004316560657 1.445756427823 0.263157894736842 4.4 4 4 weight loss 0.000138615475381936 0.0044949171542794 1.44410413476263 0.262857142857143 4.4 4 4 abnormal motor coordination/ balance 0.00362868262580713 0.0532010600146933 1.4428357077668 0.262626262626263 4.4 4 4 hydronephrosis 0.00732293111173189 0.09013237402894 1.4388718734048 0.261904761904762 4.4 4 4 arrest of spermatogenesis 0.00732293111173189 0.09013237402894 1.4388718734048 0.261904761904762 4.4 4 4 skin edema 0.0491584142166654 0.330044683843334 1.4388718734048 0.261904761904762 4.4 4 4 infertility 0.00275858897967665 0.0447035184817307 1.43764938243334 0.261682242990654 4.4 4 4 small kidney 0.0063681610782066 0.082935268424667 1.4358989976333 0.261363636363636 4.4 4 4 abnormal enzyme/coenzyme activity 0.000358469280027547 0.00919270447493324 1.43470606022181 0.261146496815287 4.4 4 4 abnormal blood vessel physiology 0.130696236259871 0.542952934942497 1.43318463279846 0.260869565217391 4.4 4 4 abnormal postnatal growth 0.130696236259871 0.542952934942497 1.43318463279846 0.260869565217391 4.4 4 4 abnormal nasal cavity morphology 0.130696236259871 0.542952934942497 1.43318463279846 0.260869565217391 4.4 4 4 decreased epididymis weight 0.130696236259871 0.542952934942497 1.43318463279846 0.260869565217391 4.4 4 4 abnormal corneal stroma morphology 0.130696236259871 0.542952934942497 1.43318463279846 0.260869565217391 4.4 4 4 abnormal lung morphology 0.0018321982606573 0.0336353739733213 1.43117737140798 0.260504201680672 4.4 4 4 abnormal fertility/fecundity 0.012970660822611 0.129139557286175 1.42991252176467 0.26027397260274 4.4 4 4 increased body length 0.0362305675683155 0.260849600075789 1.42840735068913 0.26 4.4 4 4 testicular atrophy 0.0362305675683155 0.260849600075789 1.42840735068913 0.26 4.4 4 4 cachexia 0.00365723869849751 0.0532010600146933 1.42629432206385 0.259615384615385 4.4 4 4 cleft palate 0.00121949785993456 0.0245783162729017 1.4258910723262 0.259541984732824 4.4 4 4 abnormal trigeminal nerve morphology 0.109800278525782 0.512509629519955 1.42433781407748 0.259259259259259 4.4 4 4 cryptorchism 0.109800278525782 0.512509629519955 1.42433781407748 0.259259259259259 4.4 4 4 abnormal palate morphology 0.109800278525782 0.512509629519955 1.42433781407748 0.259259259259259 4.4 4 4 abnormal skin appearance 0.109800278525782 0.512509629519955 1.42433781407748 0.259259259259259 4.4 4 4 decreased circulating fructosamine level 0.109800278525782 0.512509629519955 1.42433781407748 0.259259259259259 4.4 4 4 abnormal lung development 0.00847444352313503 0.100862096955973 1.4219439690118 0.258823529411765 4.4 4 4 increased insulin sensitivity 0.000813178960946188 0.0178218737035563 1.42149198427912 0.258741258741259 4.4 4 4 enlarged heart 2.52158549049629e-05 0.00108145584613957 1.42082959286054 0.258620689655172 4.4 4 4 cochlear ganglion degeneration 0.0268737519827442 0.209228350726373 1.42082959286054 0.258620689655172 4.4 4 4 postnatal growth retardation 1.34664038349471e-11 1.97045173761358e-09 1.41835320141329 0.258169934640523 4.4 4 4 osteopetrosis 0.0927532891919576 0.480674597635405 1.41777404534901 0.258064516129032 4.4 4 4 abnormal cranial ganglia morphology 0.0927532891919576 0.480674597635405 1.41777404534901 0.258064516129032 4.4 4 4 absent mature ovarian follicles 0.0927532891919576 0.480674597635405 1.41777404534901 0.258064516129032 4.4 4 4 abnormal postnatal growth/weight/body size 0.0927532891919576 0.480674597635405 1.41777404534901 0.258064516129032 4.4 4 4 decreased double-negative T cell number 0.0927532891919576 0.480674597635405 1.41777404534901 0.258064516129032 4.4 4 4 decreased circulating HDL cholesterol level 0.0016078796307133 0.029959554916849 1.41638950038285 0.2578125 4.4 4 4 thick pulmonary interalveolar septum 0.0786924676259556 0.42037471168297 1.41271056661562 0.257142857142857 4.4 4 4 increased circulating serum albumin level 0.0786924676259556 0.42037471168297 1.41271056661562 0.257142857142857 4.4 4 4 decreased glycogen level 0.0786924676259556 0.42037471168297 1.41271056661562 0.257142857142857 4.4 4 4 decreased body size 2.10930575805573e-14 5.82988674795958e-12 1.41133365573198 0.256892230576441 4.4 4 4 abnormal intestine morphology 0.0149947249585513 0.142636246020636 1.41058937957866 0.256756756756757 4.4 4 4 small seminiferous tubules 0.0149947249585513 0.142636246020636 1.41058937957866 0.256756756756757 4.4 4 4 kidney cysts 0.0149947249585513 0.142636246020636 1.41058937957866 0.256756756756757 4.4 4 4 male infertility 1.53887035873427e-09 1.66432174667457e-07 1.4089658069957 0.256461232604374 4.4 4 4 increased urine protein level 0.0129892979532933 0.129139557286175 1.40868575018652 0.256410256410256 4.4 4 4 abnormal leukocyte adhesion 0.0669974413842472 0.38712226583813 1.40868575018652 0.256410256410256 4.4 4 4 abnormal response to injury 0.0669974413842472 0.38712226583813 1.40868575018652 0.256410256410256 4.4 4 4 abnormal circulating hormone level 0.0669974413842472 0.38712226583813 1.40868575018652 0.256410256410256 4.4 4 4 decreased litter size 5.95956347268514e-06 0.000305658023470191 1.40768312687677 0.256227758007117 4.4 4 4 kidney failure 0.05720620858584 0.358439405182058 1.40540973681399 0.255813953488372 4.4 4 4 decreased oxygen consumption 0.05720620858584 0.358439405182058 1.40540973681399 0.255813953488372 4.4 4 4 increased sensitivity to induced morbidity/mortality 0.000243717710630738 0.00677371849378728 1.40332661961515 0.255434782608696 4.4 4 4 increased blood urea nitrogen level 0.00107133289267561 0.0223007579123897 1.40188519828906 0.255172413793103 4.4 4 4 decreased circulating calcium level 0.0360901318537843 0.260592751774422 1.39844076291243 0.254545454545455 4.4 4 4 increased hemoglobin content 0.0310612626687295 0.2306414653387 1.39674773535443 0.254237288135593 4.4 4 4 decreased susceptibility to hepatic steatosis 0.0267705357561883 0.208834661600212 1.39526969542283 0.253968253968254 4.4 4 4 increased circulating aspartate transaminase level 0.0267705357561883 0.208834661600212 1.39526969542283 0.253968253968254 4.4 4 4 abnormal lipid homeostasis 0.00211512863653145 0.0371829150768338 1.39459889268465 0.253846153846154 4.4 4 4 kyphosis 0.00106981552700588 0.0223007579123897 1.39178152118428 0.253333333333333 4.4 4 4 increased thermal nociceptive threshold 0.0097316137911526 0.11078896707319 1.38856166804099 0.252747252747253 4.4 4 4 alopecia 0.00844766320680546 0.100784471112367 1.38792617071008 0.252631578947368 4.4 4 4 abnormal neuron morphology 0.00733740934305944 0.09013237402894 1.38734202669884 0.252525252525253 4.4 4 4 ataxia 0.000186097676414454 0.00564534109854822 1.38706730550544 0.252475247524752 4.4 4 4 abnormal embryonic tissue morphology 0.00139860305787417 0.0267617315881693 1.38281193028513 0.251700680272109 4.4 4 4 abnormal liver morphology 0.00047371096587031 0.0115437907677502 1.38114161540633 0.251396648044693 4.4 4 4 abnormal lens morphology 0.00316121751038142 0.0487567372248807 1.37346860643185 0.25 4.4 4 4 increased sacral vertebrae number 0.0307472016851316 0.229680673248543 1.37346860643185 0.25 4.4 4 4 intracranial hemorrhage 0.0357070563047929 0.258913492684824 1.37346860643185 0.25 4.4 4 4 abnormal kidney physiology 0.0564790339438141 0.35612572100187 1.37346860643185 0.25 4.4 4 4 thymus atrophy 0.0564790339438141 0.35612572100187 1.37346860643185 0.25 4.4 4 4 cochlear hair cell degeneration 0.0660792511026942 0.384047049341009 1.37346860643185 0.25 4.4 4 4 decreased sensitivity to induced morbidity/mortality 0.0660792511026942 0.384047049341009 1.37346860643185 0.25 4.4 4 4 perinatal lethality 0.0775177797285423 0.42037471168297 1.37346860643185 0.25 4.4 4 4 abnormal pancreatic beta cell morphology 0.0775177797285423 0.42037471168297 1.37346860643185 0.25 4.4 4 4 scoliosis 0.107774188118953 0.512509629519955 1.37346860643185 0.25 4.4 4 4 increased circulating follicle stimulating hormone level 0.107774188118953 0.512509629519955 1.37346860643185 0.25 4.4 4 4 abnormal lumbar vertebrae morphology 0.107774188118953 0.512509629519955 1.37346860643185 0.25 4.4 4 4 abnormal heart atrium morphology 0.107774188118953 0.512509629519955 1.37346860643185 0.25 4.4 4 4 bradykinesia 0.107774188118953 0.512509629519955 1.37346860643185 0.25 4.4 4 4 abnormal auditory brainstem response waveform shape 0.107774188118953 0.512509629519955 1.37346860643185 0.25 4.4 4 4 decreased metastatic potential 0.152810221405746 0.542952934942497 1.37346860643185 0.25 4.4 4 4 abnormal vasodilation 0.152810221405746 0.542952934942497 1.37346860643185 0.25 4.4 4 4 blindness 0.152810221405746 0.542952934942497 1.37346860643185 0.25 4.4 4 4 abnormal retinal ganglion layer morphology 0.152810221405746 0.542952934942497 1.37346860643185 0.25 4.4 4 4 abnormal lung saccule morphology 0.152810221405746 0.542952934942497 1.37346860643185 0.25 4.4 4 4 waved hair 0.184021678583787 0.607100696919325 1.37346860643185 0.25 4.4 4 4 abnormal trachea morphology 0.184021678583787 0.607100696919325 1.37346860643185 0.25 4.4 4 4 abnormal physiological neovascularization 0.184021678583787 0.607100696919325 1.37346860643185 0.25 4.4 4 4 kidney atrophy 0.184021678583787 0.607100696919325 1.37346860643185 0.25 4.4 4 4 abnormal induced retinal neovascularization 0.184021678583787 0.607100696919325 1.37346860643185 0.25 4.4 4 4 abnormal neuron proliferation 0.184021678583787 0.607100696919325 1.37346860643185 0.25 4.4 4 4 increased susceptibility to bacterial infection induced morbidity/mortality 0.0228865448358264 0.194004316560657 1.37346860643185 0.25 4.4 4 4 abnormal seminal vesicle morphology 0.0415292698494422 0.288829822017985 1.37346860643185 0.25 4.4 4 4 distended pericardium 0.0483833140024167 0.326161229216833 1.37346860643185 0.25 4.4 4 4 increased susceptibility to injury 0.0483833140024167 0.326161229216833 1.37346860643185 0.25 4.4 4 4 renal hypoplasia 0.0912260625253597 0.476732837251748 1.37346860643185 0.25 4.4 4 4 narrow eye opening 0.0912260625253597 0.476732837251748 1.37346860643185 0.25 4.4 4 4 abnormal retinal blood vessel morphology 0.0912260625253597 0.476732837251748 1.37346860643185 0.25 4.4 4 4 rib bifurcation 0.12793731194186 0.542952934942497 1.37346860643185 0.25 4.4 4 4 shortened head 0.12793731194186 0.542952934942497 1.37346860643185 0.25 4.4 4 4 reddish skin 0.12793731194186 0.542952934942497 1.37346860643185 0.25 4.4 4 4 abnormal somite shape 0.12793731194186 0.542952934942497 1.37346860643185 0.25 4.4 4 4 increased bone resorption 0.12793731194186 0.542952934942497 1.37346860643185 0.25 4.4 4 4 abnormal brainstem morphology 0.12793731194186 0.542952934942497 1.37346860643185 0.25 4.4 4 4 microphthalmia 0.00157902790407537 0.0298746687895118 1.36449168743557 0.248366013071895 4.4 4 4 abnormal blood vessel morphology 0.00207481636978921 0.0367338485398623 1.36399640914612 0.248275862068966 4.4 4 4 abnormal behavior 2.82310029772491e-05 0.00119024779501537 1.36358753732083 0.248201438848921 4.4 4 4 decreased body length 3.22259727529024e-05 0.00132499350781561 1.36344328813673 0.248175182481752 4.4 4 4 abnormal bone mineralization 0.00474184456215433 0.0664526104132896 1.36211762621341 0.247933884297521 4.4 4 4 hypoglycemia 0.0126826005892869 0.129139557286175 1.3587001267928 0.247311827956989 4.4 4 4 abnormal seminiferous tubule morphology 0.00235278935983671 0.040567205145848 1.35465396798758 0.246575342465753 4.4 4 4 neonatal lethality, incomplete penetrance 6.99478963556692e-05 0.00250353082280183 1.35233832017906 0.246153846153846 4.4 4 4 abnormal maternal nurturing 0.040834672266391 0.285326537254628 1.35095272763789 0.245901639344262 4.4 4 4 abnormal facial morphology 0.0475231213097324 0.322108349476728 1.34937266596814 0.245614035087719 4.4 4 4 decreased body weight 9.28611371273816e-18 4.19985597462476e-15 1.34906124832079 0.245557350565428 4.4 4 4 kinked tail 0.0108419067918206 0.121507798858893 1.34653784944299 0.245098039215686 4.4 4 4 increased circulating creatinine level 0.0191932541871969 0.172669872660587 1.34152747604972 0.244186046511628 4.4 4 4 scaly skin 0.0890035737784864 0.467574212827846 1.33996937212864 0.24390243902439 4.4 4 4 palatal shelves fail to meet at midline 0.0890035737784864 0.467574212827846 1.33996937212864 0.24390243902439 4.4 4 4 abnormal cornea morphology 0.0256589973132497 0.206893860021746 1.33825146267719 0.243589743589744 4.4 4 4 abnormal heart ventricle morphology 0.0256589973132497 0.206893860021746 1.33825146267719 0.243589743589744 4.4 4 4 increased circulating phosphate level 0.104860816922009 0.512509629519955 1.33634783328505 0.243243243243243 4.4 4 4 abnormal hair follicle development 0.104860816922009 0.512509629519955 1.33634783328505 0.243243243243243 4.4 4 4 belly spot 0.124041929797434 0.542952934942497 1.33184834563089 0.242424242424242 4.4 4 4 absent vibrissae 0.124041929797434 0.542952934942497 1.33184834563089 0.242424242424242 4.4 4 4 decreased sensitivity to xenobiotic induced morbidity/mortality 0.124041929797434 0.542952934942497 1.33184834563089 0.242424242424242 4.4 4 4 impaired glucose tolerance 0.000191189761578812 0.00572993411960595 1.3291631675147 0.241935483870968 4.4 4 4 decreased retinal photoreceptor cell number 0.147467982599582 0.542952934942497 1.32610762000317 0.241379310344828 4.4 4 4 aphagia 0.147467982599582 0.542952934942497 1.32610762000317 0.241379310344828 4.4 4 4 stomach inflammation 0.147467982599582 0.542952934942497 1.32610762000317 0.241379310344828 4.4 4 4 abnormal embryonic erythropoiesis 0.147467982599582 0.542952934942497 1.32610762000317 0.241379310344828 4.4 4 4 abnormal axon morphology 0.0120287834485628 0.129139557286175 1.32259939878623 0.240740740740741 4.4 4 4 neurodegeneration 0.0630860423248067 0.374025529493561 1.32259939878623 0.240740740740741 4.4 4 4 decreased tumor growth/size 0.0630860423248067 0.374025529493561 1.32259939878623 0.240740740740741 4.4 4 4 abnormal kidney morphology 0.00189226188318846 0.0342327377049549 1.31852986217458 0.24 4.4 4 4 short stride length 0.0737253970209572 0.415485018346702 1.31852986217458 0.24 4.4 4 4 increased circulating chloride level 0.0737253970209572 0.415485018346702 1.31852986217458 0.24 4.4 4 4 abnormal circulating protein level 0.0737253970209572 0.415485018346702 1.31852986217458 0.24 4.4 4 4 decreased oocyte number 0.0737253970209572 0.415485018346702 1.31852986217458 0.24 4.4 4 4 diaphragmatic hernia 0.176444066657873 0.585987471043336 1.31852986217458 0.24 4.4 4 4 abnormal cochlear outer hair cell morphology 0.176444066657873 0.585987471043336 1.31852986217458 0.24 4.4 4 4 abnormal skeletal muscle fiber morphology 0.039002950905318 0.273295325005573 1.31543472165304 0.23943661971831 4.4 4 4 neonatal lethality, complete penetrance 1.19662291255199e-06 7.17252890354957e-05 1.31322875527256 0.239035087719298 4.4 4 4 disheveled coat 0.101455186141555 0.512509629519955 1.30806533945891 0.238095238095238 4.4 4 4 abnormal clavicle morphology 0.212916033792838 0.675116168336117 1.30806533945891 0.238095238095238 4.4 4 4 abnormal bile salt homeostasis 0.212916033792838 0.675116168336117 1.30806533945891 0.238095238095238 4.4 4 4 abnormal tumor vascularization 0.212916033792838 0.675116168336117 1.30806533945891 0.238095238095238 4.4 4 4 increased bone ossification 0.212916033792838 0.675116168336117 1.30806533945891 0.238095238095238 4.4 4 4 abnormal pulmonary alveolus morphology 0.0179604976161184 0.165163540924564 1.30547511106394 0.237623762376238 4.4 4 4 no abnormal phenotype detected 6.60382592385678e-21 3.65044821902083e-18 1.30459726997101 0.237463976945245 4.4 4 4 decreased grip strength 0.000778314996434327 0.0172862370859856 1.30448159880286 0.237442922374429 4.4 4 4 reduced fertility 0.00644577735236433 0.082935268424667 1.30430112265471 0.237410071942446 4.4 4 4 respiratory distress 0.00271792760572634 0.0441885288839495 1.30201648239783 0.236994219653179 4.4 4 4 abnormal frontal bone morphology 0.119579735771213 0.530661981254222 1.3011807850407 0.236842105263158 4.4 4 4 impaired branching involved in ureteric bud morphogenesis 0.119579735771213 0.530661981254222 1.3011807850407 0.236842105263158 4.4 4 4 abnormal blood homeostasis 0.0132099337585417 0.129139557286175 1.3011807850407 0.236842105263158 4.4 4 4 decreased circulating glucose level 0.000189936868918782 0.005726884381036 1.29962620823659 0.236559139784946 4.4 4 4 lethargy 0.0238846677368443 0.195116949081774 1.29962620823659 0.236559139784946 4.4 4 4 increased startle reflex 0.0275730361341999 0.214337273074445 1.29630744876714 0.235955056179775 4.4 4 4 small testis 0.000241310808276481 0.00674450152345781 1.29384723794305 0.235507246376812 4.4 4 4 abnormal extraembryonic tissue morphology 0.020150833254364 0.180175819735383 1.29267633546527 0.235294117647059 4.4 4 4 decreased circulating alanine transaminase level 0.0510438534701894 0.332565543673946 1.29267633546527 0.235294117647059 4.4 4 4 abnormal gastrulation 0.0834871548635651 0.443168060167978 1.29267633546527 0.235294117647059 4.4 4 4 abnormal gluconeogenesis 0.0834871548635651 0.443168060167978 1.29267633546527 0.235294117647059 4.4 4 4 abnormal vision 0.141511688341005 0.542952934942497 1.29267633546527 0.235294117647059 4.4 4 4 abnormal brown adipose tissue morphology 0.141511688341005 0.542952934942497 1.29267633546527 0.235294117647059 4.4 4 4 decreased osteoblast cell number 0.141511688341005 0.542952934942497 1.29267633546527 0.235294117647059 4.4 4 4 increased susceptibility to viral infection induced morbidity/mortality 0.141511688341005 0.542952934942497 1.29267633546527 0.235294117647059 4.4 4 4 decreased eosinophil cell number 0.0593167640224881 0.369800627834434 1.28762681852986 0.234375 4.4 4 4 cleft secondary palate 0.0267812088645096 0.208834661600212 1.28580039751067 0.234042553191489 4.4 4 4 pulmonary hypoplasia 0.0977926003303863 0.50364201515908 1.28580039751067 0.234042553191489 4.4 4 4 decreased bone trabecula number 0.0977926003303863 0.50364201515908 1.28580039751067 0.234042553191489 4.4 4 4 polyuria 0.0426378883561334 0.294207343372765 1.28428233328693 0.233766233766234 4.4 4 4 reduced male fertility 0.00105153220952757 0.022169556577091 1.28271076900244 0.233480176211454 4.4 4 4 abnormal kidney development 0.0690355758678563 0.393866960943332 1.28190403266973 0.233333333333333 4.4 4 4 abnormal heart tube morphology 0.168303320145255 0.573350941959555 1.28190403266973 0.233333333333333 4.4 4 4 liver hemorrhage 0.168303320145255 0.573350941959555 1.28190403266973 0.233333333333333 4.4 4 4 abnormal organ of Corti morphology 0.114863967219045 0.512509629519955 1.27764521528544 0.232558139534884 4.4 4 4 abnormal left-right axis patterning 0.114863967219045 0.512509629519955 1.27764521528544 0.232558139534884 4.4 4 4 abnormal blood circulation 0.114863967219045 0.512509629519955 1.27764521528544 0.232558139534884 4.4 4 4 delayed endochondral bone ossification 0.114863967219045 0.512509629519955 1.27764521528544 0.232558139534884 4.4 4 4 abnormal heart looping 0.135354424087303 0.542952934942497 1.26781717516786 0.230769230769231 4.4 4 4 abnormal lens fiber morphology 0.135354424087303 0.542952934942497 1.26781717516786 0.230769230769231 4.4 4 4 decreased kidney weight 0.0940183071219096 0.485712438142783 1.26781717516786 0.230769230769231 4.4 4 4 ventricular hypoplasia 0.201438989652514 0.641176566552307 1.26781717516786 0.230769230769231 4.4 4 4 abnormal stomach morphology 0.201438989652514 0.641176566552307 1.26781717516786 0.230769230769231 4.4 4 4 abnormal ureter morphology 0.201438989652514 0.641176566552307 1.26781717516786 0.230769230769231 4.4 4 4 increased susceptibility to otitis media 0.201438989652514 0.641176566552307 1.26781717516786 0.230769230769231 4.4 4 4 abnormal vertebrae morphology 0.0243298750352151 0.198428079180647 1.2600629416806 0.229357798165138 4.4 4 4 decreased bone mineral density 0.000757920471953026 0.0169087638922256 1.25987345853147 0.229323308270677 4.4 4 4 overriding aortic valve 0.110075011958827 0.512509629519955 1.2590128892292 0.229166666666667 4.4 4 4 oligodactyly 0.110075011958827 0.512509629519955 1.2590128892292 0.229166666666667 4.4 4 4 ovary cysts 0.160124790775094 0.554363837234581 1.25574272588055 0.228571428571429 4.4 4 4 decreased bone mineralization 0.160124790775094 0.554363837234581 1.25574272588055 0.228571428571429 4.4 4 4 absent vitelline blood vessels 0.0902240977143637 0.472987235120084 1.25298890411327 0.228070175438596 4.4 4 4 abnormal gametogenesis 0.129212413135618 0.542952934942497 1.24860782402896 0.227272727272727 4.4 4 4 abnormal germ layer development 0.243114505524724 0.721225202734348 1.24860782402896 0.227272727272727 4.4 4 4 abnormal oogenesis 0.243114505524724 0.721225202734348 1.24860782402896 0.227272727272727 4.4 4 4 abnormal chorion morphology 0.243114505524724 0.721225202734348 1.24860782402896 0.227272727272727 4.4 4 4 increased coping response 0.243114505524724 0.721225202734348 1.24860782402896 0.227272727272727 4.4 4 4 parakeratosis 0.243114505524724 0.721225202734348 1.24860782402896 0.227272727272727 4.4 4 4 abnormal female reproductive system physiology 0.243114505524724 0.721225202734348 1.24860782402896 0.227272727272727 4.4 4 4 cleft upper lip 0.243114505524724 0.721225202734348 1.24860782402896 0.227272727272727 4.4 4 4 rough coat 0.243114505524724 0.721225202734348 1.24860782402896 0.227272727272727 4.4 4 4 abnormal myocardial fiber morphology 0.037080395529821 0.261295988329829 1.24603337490725 0.22680412371134 4.4 4 4 enlarged kidney 0.105319667504221 0.512509629519955 1.24389609639111 0.226415094339623 4.4 4 4 decreased inflammatory response 0.0512273095454942 0.332565543673946 1.24266207248596 0.226190476190476 4.4 4 4 abnormal skeleton morphology 0.0260583672052641 0.208079620012462 1.24209334842533 0.226086956521739 4.4 4 4 pericardial effusion 0.0864687297641404 0.455855196067818 1.24055228968038 0.225806451612903 4.4 4 4 abnormal eyelid morphology 0.190338745839966 0.609353449519841 1.24055228968038 0.225806451612903 4.4 4 4 abnormal object recognition memory 0.190338745839966 0.609353449519841 1.24055228968038 0.225806451612903 4.4 4 4 preaxial polydactyly 0.190338745839966 0.609353449519841 1.24055228968038 0.225806451612903 4.4 4 4 decreased susceptibility to bacterial infection induced morbidity/mortality 0.190338745839966 0.609353449519841 1.24055228968038 0.225806451612903 4.4 4 4 female infertility 0.00127418444573421 0.0251550302282845 1.23921979527686 0.225563909774436 4.4 4 4 atelectasis 0.0713832323234102 0.405864663781675 1.23805620861463 0.225352112676056 4.4 4 4 abnormal glucose homeostasis 0.00694460913349564 0.0866248666243938 1.23763105194958 0.225274725274725 4.4 4 4 increased susceptibility to weight loss 0.152145707933395 0.542952934942497 1.23612174578867 0.225 4.4 4 4 cyanosis 0.0064759110065202 0.082935268424667 1.23039895992853 0.223958333333333 4.4 4 4 abnormal retina morphology 0.00465347342772493 0.0653983906862473 1.22958141909137 0.223809523809524 4.4 4 4 postnatal lethality, incomplete penetrance 6.53457603828891e-06 0.000325095157904873 1.22838389448483 0.223591549295775 4.4 4 4 abnormal craniofacial morphology 0.0395003061948079 0.276391031391236 1.2267874931236 0.223300970873786 4.4 4 4 abnormal ovarian follicle morphology 0.144474474384023 0.542952934942497 1.22086098349498 0.222222222222222 4.4 4 4 abnormal ectoderm development 0.144474474384023 0.542952934942497 1.22086098349498 0.222222222222222 4.4 4 4 abnormal skeleton development 0.0655704509820277 0.381982428144717 1.22086098349498 0.222222222222222 4.4 4 4 skin lesions 0.0961395745968464 0.496155999605094 1.22086098349498 0.222222222222222 4.4 4 4 abnormal mandible morphology 0.117386417555483 0.522359058442331 1.22086098349498 0.222222222222222 4.4 4 4 impaired limb coordination 0.117386417555483 0.522359058442331 1.22086098349498 0.222222222222222 4.4 4 4 axon degeneration 0.117386417555483 0.522359058442331 1.22086098349498 0.222222222222222 4.4 4 4 rectal prolapse 0.227621478545866 0.697732310621632 1.22086098349498 0.222222222222222 4.4 4 4 wrinkled skin 0.227621478545866 0.697732310621632 1.22086098349498 0.222222222222222 4.4 4 4 abnormal brain commissure morphology 0.227621478545866 0.697732310621632 1.22086098349498 0.222222222222222 4.4 4 4 abnormal bone trabecula morphology 0.227621478545866 0.697732310621632 1.22086098349498 0.222222222222222 4.4 4 4 decreased bone ossification 0.227621478545866 0.697732310621632 1.22086098349498 0.222222222222222 4.4 4 4 increased bone mineral density 0.0364417251329138 0.261158891691591 1.215458943745 0.221238938053097 4.4 4 4 obese 0.0757481932415846 0.417790755406744 1.21293331477099 0.220779220779221 4.4 4 4 decreased respiratory quotient 0.137157160911327 0.542952934942497 1.20865237366003 0.22 4.4 4 4 increased grip strength 0.060103517135494 0.371909201180451 1.2074449287313 0.21978021978022 4.4 4 4 insulin resistance 0.0281671805363388 0.215840886740304 1.20698756322799 0.21969696969697 4.4 4 4 thick ventricular wall 0.169904433164463 0.573350941959555 1.20597243491577 0.219512195121951 4.4 4 4 retinal degeneration 0.0575136832937601 0.359009503621652 1.20178503062787 0.21875 4.4 4 4 abnormal lymphatic vessel morphology 0.21345682200185 0.675969248541824 1.20178503062787 0.21875 4.4 4 4 pancreatic islet hyperplasia 0.21345682200185 0.675969248541824 1.20178503062787 0.21875 4.4 4 4 decreased total body fat amount 0.00105313415984526 0.022169556577091 1.20075698526378 0.218562874251497 4.4 4 4 increased sensitivity to xenobiotic induced morbidity/mortality 0.0459190419591445 0.315534853241359 1.1986635110678 0.218181818181818 4.4 4 4 absent gastric milk in neonates 0.083556108630666 0.443168060167978 1.19738288765854 0.217948717948718 4.4 4 4 abnormal bone structure 0.0116346479228497 0.126935029421441 1.1955581651842 0.217616580310881 4.4 4 4 hyperkeratosis 0.101347956327139 0.512509629519955 1.19432052733205 0.217391304347826 4.4 4 4 delayed wound healing 0.160615999579776 0.55529158993008 1.19432052733205 0.217391304347826 4.4 4 4 abnormal myelin sheath morphology 0.160615999579776 0.55529158993008 1.19432052733205 0.217391304347826 4.4 4 4 abnormal pulmonary artery morphology 0.274341802542738 0.734679770357846 1.19432052733205 0.217391304347826 4.4 4 4 pancreas inflammation 0.274341802542738 0.734679770357846 1.19432052733205 0.217391304347826 4.4 4 4 abnormal sacral vertebrae morphology 0.274341802542738 0.734679770357846 1.19432052733205 0.217391304347826 4.4 4 4 abnormal regulatory T cell physiology 0.274341802542738 0.734679770357846 1.19432052733205 0.217391304347826 4.4 4 4 increased susceptibility to fungal infection 0.274341802542738 0.734679770357846 1.19432052733205 0.217391304347826 4.4 4 4 abnormal lens development 0.274341802542738 0.734679770357846 1.19432052733205 0.217391304347826 4.4 4 4 decreased effector memory CD8-positive, alpha-beta T cell number 0.274341802542738 0.734679770357846 1.19432052733205 0.217391304347826 4.4 4 4 abnormal lipid level 0.07970798609622 0.42456876962387 1.19144264654329 0.216867469879518 4.4 4 4 muscular ventricular septal defect 0.123625235196691 0.542952934942497 1.19033945890761 0.216666666666667 4.4 4 4 decreased bone mineral content 0.0103131913482589 0.116875004459198 1.18857860171987 0.216346153846154 4.4 4 4 abnormal calcium ion homeostasis 0.200485817505405 0.640437706552028 1.18786474069782 0.216216216216216 4.4 4 4 impaired balance 0.0603317572495829 0.372857754430652 1.18495330750983 0.215686274509804 4.4 4 4 failure of chorioallantoic fusion 0.151916412574462 0.542952934942497 1.18495330750983 0.215686274509804 4.4 4 4 spina bifida 0.188572409625256 0.609353449519841 1.17725880551302 0.214285714285714 4.4 4 4 abnormal stria vascularis morphology 0.254808069437867 0.734679770357846 1.17725880551302 0.214285714285714 4.4 4 4 abnormal hormone level 0.254808069437867 0.734679770357846 1.17725880551302 0.214285714285714 4.4 4 4 decreased circulating progesterone level 0.254808069437867 0.734679770357846 1.17725880551302 0.214285714285714 4.4 4 4 improved glucose tolerance 0.0150398326542453 0.142792304303188 1.17725880551302 0.214285714285714 4.4 4 4 polydactyly 0.0691782723604818 0.394228986246732 1.17725880551302 0.214285714285714 4.4 4 4 decreased circulating cholesterol level 0.0201724485613283 0.180175819735383 1.17082569728617 0.213114754098361 4.4 4 4 increased respiratory quotient 0.177595296674205 0.589417345533136 1.16890945228243 0.212765957446809 4.4 4 4 abnormal posture 0.100686861540115 0.511139934859259 1.16744831546707 0.2125 4.4 4 4 dextrocardia 0.237530062210731 0.708460467325173 1.16536730242703 0.212121212121212 4.4 4 4 dilated heart atrium 0.237530062210731 0.708460467325173 1.16536730242703 0.212121212121212 4.4 4 4 diarrhea 0.237530062210731 0.708460467325173 1.16536730242703 0.212121212121212 4.4 4 4 decreased liver weight 0.122258539413955 0.540654429852822 1.16067769557621 0.211267605633803 4.4 4 4 abnormal retinal outer nuclear layer morphology 0.222060772634522 0.697732310621632 1.1566051422584 0.210526315789474 4.4 4 4 abnormal craniofacial bone morphology 0.158047536522518 0.547934839163433 1.1566051422584 0.210526315789474 4.4 4 4 abnormal circulating amino acid level 0.158047536522518 0.547934839163433 1.1566051422584 0.210526315789474 4.4 4 4 abnormal trabecular bone morphology 0.06232529832232 0.374025529493561 1.15417529952257 0.210084033613445 4.4 4 4 increased eosinophil cell number 0.149311590582618 0.542952934942497 1.15194141184607 0.209677419354839 4.4 4 4 increased oxygen consumption 0.104431132832848 0.512509629519955 1.1498806937569 0.209302325581395 4.4 4 4 abnormal cranium morphology 0.0540252943913487 0.344264137173851 1.14797376059976 0.208955223880597 4.4 4 4 hydroencephaly 0.0710361121766547 0.404353155696633 1.14654770623876 0.208695652173913 4.4 4 4 curly vibrissae 0.306323797578789 0.7689005514402 1.14455717202654 0.208333333333333 4.4 4 4 decreased fatty acid level 0.306323797578789 0.7689005514402 1.14455717202654 0.208333333333333 4.4 4 4 increased circulating total protein level 0.306323797578789 0.7689005514402 1.14455717202654 0.208333333333333 4.4 4 4 abnormal truncus arteriosus septation 0.306323797578789 0.7689005514402 1.14455717202654 0.208333333333333 4.4 4 4 abnormal response/metabolism to endogenous compounds 0.119850107921927 0.530947717641664 1.13897396630934 0.207317073170732 4.4 4 4 abnormal microglial cell morphology 0.282809831221768 0.734679770357846 1.13666367428843 0.206896551724138 4.4 4 4 abnormal spinal nerve morphology 0.282809831221768 0.734679770357846 1.13666367428843 0.206896551724138 4.4 4 4 enlarged epididymis 0.282809831221768 0.734679770357846 1.13666367428843 0.206896551724138 4.4 4 4 gliosis 0.163136314738918 0.56361330960147 1.13365662753105 0.206349206349206 4.4 4 4 abnormal retinal photoreceptor morphology 0.262423714695475 0.734679770357846 1.13109179353211 0.205882352941176 4.4 4 4 lung hemorrhage 0.262423714695475 0.734679770357846 1.13109179353211 0.205882352941176 4.4 4 4 thin skin 0.262423714695475 0.734679770357846 1.13109179353211 0.205882352941176 4.4 4 4 decreased startle reflex 0.0833183663972089 0.443168060167978 1.12694860014921 0.205128205128205 4.4 4 4 increased circulating alanine transaminase level 0.137572415207943 0.542952934942497 1.12694860014921 0.205128205128205 4.4 4 4 abnormal brain morphology 0.0497069331891607 0.331863775403322 1.12607364005593 0.204968944099379 4.4 4 4 abnormal astrocyte morphology 0.228364596279616 0.697732310621632 1.12374704162606 0.204545454545455 4.4 4 4 short snout 0.0997337176298116 0.506818432286325 1.11912256820373 0.203703703703704 4.4 4 4 abnormal osteoblast physiology 0.200691936585852 0.640437706552028 1.11912256820373 0.203703703703704 4.4 4 4 abnormal cardiovascular system physiology 0.0772899761969625 0.42037471168297 1.11529781574917 0.203007518796992 4.4 4 4 abnormal food intake 0.167383263011028 0.573350941959555 1.11469915884324 0.202898550724638 4.4 4 4 hunched posture 0.149179940893453 0.542952934942497 1.11268342799543 0.20253164556962 4.4 4 4 abnormal muscle physiology 0.133426265433044 0.542952934942497 1.11112067037184 0.202247191011236 4.4 4 4 deafness 0.119678943309997 0.530661981254222 1.10987362135907 0.202020202020202 4.4 4 4 abnormal nervous system physiology 0.109879210793057 0.512509629519955 1.09877488514548 0.2 4.4 4 4 increased circulating HDL cholesterol level 0.12221769142839 0.540654429852822 1.09877488514548 0.2 4.4 4 4 impaired fertilization 0.181351519989022 0.600681632453652 1.09877488514548 0.2 4.4 4 4 domed cranium 0.181351519989022 0.600681632453652 1.09877488514548 0.2 4.4 4 4 dehydration 0.181351519989022 0.600681632453652 1.09877488514548 0.2 4.4 4 4 abnormal contextual conditioning behavior 0.218312886237854 0.689591497798937 1.09877488514548 0.2 4.4 4 4 abnormal learning/memory/conditioning 0.218312886237854 0.689591497798937 1.09877488514548 0.2 4.4 4 4 abnormal joint morphology 0.218312886237854 0.689591497798937 1.09877488514548 0.2 4.4 4 4 abnormal female reproductive system morphology 0.267509328663746 0.734679770357846 1.09877488514548 0.2 4.4 4 4 impaired ovarian folliculogenesis 0.267509328663746 0.734679770357846 1.09877488514548 0.2 4.4 4 4 albuminuria 0.249337126753514 0.734679770357846 1.09877488514548 0.2 4.4 4 4 decreased osteoclast cell number 0.249337126753514 0.734679770357846 1.09877488514548 0.2 4.4 4 4 lethality at weaning, complete penetrance 0.249337126753514 0.734679770357846 1.09877488514548 0.2 4.4 4 4 abnormal artery morphology 0.28799844567557 0.742764265026419 1.09877488514548 0.2 4.4 4 4 decreased triglyceride level 0.28799844567557 0.742764265026419 1.09877488514548 0.2 4.4 4 4 impaired behavioral response to xenobiotic 0.28799844567557 0.742764265026419 1.09877488514548 0.2 4.4 4 4 decreased bone volume 0.28799844567557 0.742764265026419 1.09877488514548 0.2 4.4 4 4 abnormal response to new environment 0.311436458990896 0.780159306888071 1.09877488514548 0.2 4.4 4 4 abnormal lactation 0.311436458990896 0.780159306888071 1.09877488514548 0.2 4.4 4 4 emphysema 0.311436458990896 0.780159306888071 1.09877488514548 0.2 4.4 4 4 ruffled hair 0.338793730309018 0.831934258779549 1.09877488514548 0.2 4.4 4 4 mandible hypoplasia 0.338793730309018 0.831934258779549 1.09877488514548 0.2 4.4 4 4 spontaneous skin ulceration 0.338793730309018 0.831934258779549 1.09877488514548 0.2 4.4 4 4 decreased placenta weight 0.338793730309018 0.831934258779549 1.09877488514548 0.2 4.4 4 4 abnormal preimplantation embryo development 0.338793730309018 0.831934258779549 1.09877488514548 0.2 4.4 4 4 abnormal urine homeostasis 0.146639317761184 0.542952934942497 1.08732931342522 0.197916666666667 4.4 4 4 decreased heart weight 0.173928085227092 0.57879078528748 1.08520976310665 0.197530864197531 4.4 4 4 corneal opacity 0.195865585393425 0.626241187231548 1.0832991825378 0.197183098591549 4.4 4 4 increased circulating free fatty acid level 0.195865585393425 0.626241187231548 1.0832991825378 0.197183098591549 4.4 4 4 abnormal vascular development 0.208246605294991 0.661997994468102 1.0821267808251 0.196969696969697 4.4 4 4 abnormal skin morphology 0.208246605294991 0.661997994468102 1.0821267808251 0.196969696969697 4.4 4 4 postnatal lethality, complete penetrance 0.0132570138115013 0.129139557286175 1.08169548278571 0.196891191709845 4.4 4 4 abnormal eye development 0.236534745182959 0.70676297734848 1.0791539050536 0.196428571428571 4.4 4 4 abnormal cued conditioning behavior 0.252831433979952 0.734679770357846 1.07723027955439 0.196078431372549 4.4 4 4 increased kidney weight 0.252831433979952 0.734679770357846 1.07723027955439 0.196078431372549 4.4 4 4 abnormal inner ear morphology 0.270917941471451 0.734679770357846 1.07488847459884 0.195652173913043 4.4 4 4 abnormal sleep pattern 0.270917941471451 0.734679770357846 1.07488847459884 0.195652173913043 4.4 4 4 increased tumor growth/size 0.291171121512057 0.743941129073058 1.07197549770291 0.195121951219512 4.4 4 4 short humerus 0.291171121512057 0.743941129073058 1.07197549770291 0.195121951219512 4.4 4 4 abnormal cholesterol homeostasis 0.291171121512057 0.743941129073058 1.07197549770291 0.195121951219512 4.4 4 4 abnormal epidermis stratum granulosum morphology 0.314112863875704 0.786072181982709 1.06825336055811 0.194444444444444 4.4 4 4 hyperactivity 0.0211651112626056 0.187027404141142 1.06619665404952 0.194070080862534 4.4 4 4 increased lung adenoma incidence 0.340499910147119 0.834785005308611 1.06333053401176 0.193548387096774 4.4 4 4 abnormal suckling behavior 0.18916304356802 0.609353449519841 1.06131665042461 0.193181818181818 4.4 4 4 short femur 0.18916304356802 0.609353449519841 1.06131665042461 0.193181818181818 4.4 4 4 increased circulating triglyceride level 0.118314529657418 0.526018574660996 1.06088609600253 0.193103448275862 4.4 4 4 short tail 0.200613576126895 0.640437706552028 1.05906013026071 0.192771084337349 4.4 4 4 abnormal rib morphology 0.131313971399258 0.542952934942497 1.05807951902898 0.192592592592593 4.4 4 4 abnormal hair growth 0.273160334779296 0.734679770357846 1.05651431263989 0.192307692307692 4.4 4 4 decreased body temperature 0.273160334779296 0.734679770357846 1.05651431263989 0.192307692307692 4.4 4 4 abnormal kidney cortex morphology 0.371497239989138 0.864587665038883 1.05651431263989 0.192307692307692 4.4 4 4 abnormal Schwann cell morphology 0.371497239989138 0.864587665038883 1.05651431263989 0.192307692307692 4.4 4 4 abnormal Mullerian duct morphology 0.371497239989138 0.864587665038883 1.05651431263989 0.192307692307692 4.4 4 4 increased body weight 0.0715098618788524 0.406120505533437 1.05462767993874 0.191964285714286 4.4 4 4 neuron degeneration 0.293020673133957 0.743941129073058 1.05201850705419 0.191489361702128 4.4 4 4 abnormal gait 0.0448593303151755 0.309106881326868 1.0489922042651 0.190938511326861 4.4 4 4 decreased exploration in new environment 0.214633781664519 0.679264035484084 1.04645227156713 0.19047619047619 4.4 4 4 abnormal optic nerve morphology 0.315311994897187 0.787309658827746 1.04645227156713 0.19047619047619 4.4 4 4 abnormal vibrissa morphology 0.315311994897187 0.787309658827746 1.04645227156713 0.19047619047619 4.4 4 4 abnormal muscle morphology 0.315311994897187 0.787309658827746 1.04645227156713 0.19047619047619 4.4 4 4 abnormal motor capabilities/coordination/movement 0.15648310649515 0.545958806155995 1.04050652002413 0.189393939393939 4.4 4 4 abnormal vocalization 0.340625841362107 0.834785005308611 1.03938164811059 0.189189189189189 4.4 4 4 decreased width of hypertrophic chondrocyte zone 0.340625841362107 0.834785005308611 1.03938164811059 0.189189189189189 4.4 4 4 abnormal respiratory electron transport chain 0.340625841362107 0.834785005308611 1.03938164811059 0.189189189189189 4.4 4 4 perimembraneous ventricular septal defect 0.258132704575026 0.734679770357846 1.03507779035444 0.188405797101449 4.4 4 4 increased circulating insulin level 0.143417792053217 0.542952934942497 1.03010145482389 0.1875 4.4 4 4 increased circulating cholesterol level 0.1302963947968 0.542952934942497 1.03010145482389 0.1875 4.4 4 4 abnormal intestinal epithelium morphology 0.315556876322115 0.787309658827746 1.03010145482389 0.1875 4.4 4 4 abnormal cardiovascular system morphology 0.315556876322115 0.787309658827746 1.03010145482389 0.1875 4.4 4 4 curly tail 0.315556876322115 0.787309658827746 1.03010145482389 0.1875 4.4 4 4 kidney cortex cysts 0.369817545872951 0.864587665038883 1.03010145482389 0.1875 4.4 4 4 increased or absent threshold for auditory brainstem response 0.0730714248327893 0.414515779410635 1.02653708992831 0.186851211072664 4.4 4 4 small ovary 0.229868028167875 0.697732310621632 1.0263281894216 0.186813186813187 4.4 4 4 hyporesponsive to tactile stimuli 0.367398598816722 0.864587665038883 1.0120294994761 0.184210526315789 4.4 4 4 abnormal craniofacial development 0.338437149775031 0.831934258779549 1.00907897615401 0.183673469387755 4.4 4 4 increased liver weight 0.274663085236224 0.734679770357846 0.998886259223166 0.181818181818182 4.4 4 4 abnormal circadian rhythm 0.364589544986609 0.864587665038883 0.998886259223166 0.181818181818182 4.4 4 4 omphalocele 0.364589544986609 0.864587665038883 0.998886259223166 0.181818181818182 4.4 4 4 embryonic lethality, incomplete penetrance 0.364589544986609 0.864587665038883 0.998886259223166 0.181818181818182 4.4 4 4 abnormal tooth development 0.399214764464554 0.874160850885192 0.998886259223166 0.181818181818182 4.4 4 4 cardiovascular system phenotype 0.399214764464554 0.874160850885192 0.998886259223166 0.181818181818182 4.4 4 4 abnormal neuromuscular synapse morphology 0.311731610449614 0.780505667834338 0.991949549089672 0.180555555555556 4.4 4 4 hypoactivity 0.0896065488999507 0.470245338372632 0.99093756220017 0.180371352785146 4.4 4 4 abnormal male meiosis 0.334671154532447 0.824251977128181 0.990698666934451 0.180327868852459 4.4 4 4 abnormal digestive system physiology 0.361572193044489 0.864587665038883 0.988897396630934 0.18 4.4 4 4 decreased circulating alkaline phosphatase level 0.361572193044489 0.864587665038883 0.988897396630934 0.18 4.4 4 4 increased total body fat amount 0.241465748850263 0.719767585698059 0.983977509085507 0.17910447761194 4.4 4 4 abnormal nervous system electrophysiology 0.308450859954525 0.773849232614102 0.981049004594181 0.178571428571429 4.4 4 4 enhanced long term potentiation 0.358448374925749 0.858998393668401 0.981049004594181 0.178571428571429 4.4 4 4 abnormal circulating cholesterol level 0.436671973907514 0.931579361144889 0.981049004594181 0.178571428571429 4.4 4 4 myoclonus 0.436671973907514 0.931579361144889 0.981049004594181 0.178571428571429 4.4 4 4 increased circulating luteinizing hormone level 0.436671973907514 0.931579361144889 0.981049004594181 0.178571428571429 4.4 4 4 absent corpus callosum 0.436671973907514 0.931579361144889 0.981049004594181 0.178571428571429 4.4 4 4 straub tail 0.436671973907514 0.931579361144889 0.981049004594181 0.178571428571429 4.4 4 4 abnormal retinal inner nuclear layer morphology 0.436671973907514 0.931579361144889 0.981049004594181 0.178571428571429 4.4 4 4 increased triglyceride level 0.436671973907514 0.931579361144889 0.981049004594181 0.178571428571429 4.4 4 4 corneal vascularization 0.436671973907514 0.931579361144889 0.981049004594181 0.178571428571429 4.4 4 4 abnormal metabolism 0.389508986766738 0.864587665038883 0.976688786795984 0.177777777777778 4.4 4 4 abnormal dendritic spine morphology 0.384873784272604 0.864587665038883 0.969507251598955 0.176470588235294 4.4 4 4 short maxilla 0.428527132272214 0.918536183995806 0.969507251598955 0.176470588235294 4.4 4 4 impaired synaptic plasticity 0.428527132272214 0.918536183995806 0.969507251598955 0.176470588235294 4.4 4 4 abnormal nervous system development 0.428527132272214 0.918536183995806 0.969507251598955 0.176470588235294 4.4 4 4 seizures 0.298928565161987 0.751855213185483 0.963837618548669 0.175438596491228 4.4 4 4 abnormal retinal pigment epithelium morphology 0.345791364233994 0.84702709850523 0.961428024502297 0.175 4.4 4 4 decreased circulating phosphate level 0.421190790973918 0.904369523131308 0.961428024502297 0.175 4.4 4 4 abnormal skin pigmentation 0.421190790973918 0.904369523131308 0.961428024502297 0.175 4.4 4 4 abnormal hair follicle morphology 0.376065437431114 0.864587665038883 0.959247915603199 0.174603174603175 4.4 4 4 abnormal epidermal layer morphology 0.371880166754306 0.864587665038883 0.955456421865637 0.173913043478261 4.4 4 4 abnormal coat appearance 0.371880166754306 0.864587665038883 0.955456421865637 0.173913043478261 4.4 4 4 impaired coordination 0.175255665506068 0.582818807414898 0.95269498712036 0.173410404624277 4.4 4 4 abnormal limb morphology 0.367829695733437 0.864587665038883 0.952271567126085 0.173333333333333 4.4 4 4 abnormal skin condition 0.408255669050272 0.89035565422374 0.950862881375898 0.173076923076923 4.4 4 4 eyelids open at birth 0.408255669050272 0.89035565422374 0.950862881375898 0.173076923076923 4.4 4 4 abnormal female meiosis 0.408255669050272 0.89035565422374 0.950862881375898 0.173076923076923 4.4 4 4 abnormal middle ear morphology 0.468726586967045 0.953452332211627 0.947219728573692 0.172413793103448 4.4 4 4 short sternum 0.468726586967045 0.953452332211627 0.947219728573692 0.172413793103448 4.4 4 4 thick epidermis 0.391791055845417 0.864587665038883 0.941807044410413 0.171428571428571 4.4 4 4 abnormal dermal layer morphology 0.457602032947382 0.953452332211627 0.941807044410413 0.171428571428571 4.4 4 4 abnormal intestinal goblet cell morphology 0.457602032947382 0.953452332211627 0.941807044410413 0.171428571428571 4.4 4 4 decreased circulating thyroxine level 0.457602032947382 0.953452332211627 0.941807044410413 0.171428571428571 4.4 4 4 abnormal excitatory postsynaptic potential 0.382160675637944 0.864587665038883 0.937978560490046 0.170731707317073 4.4 4 4 lethality at weaning, incomplete penetrance 0.44795954645136 0.948743611577486 0.937978560490046 0.170731707317073 4.4 4 4 hyperglycemia 0.377654280890839 0.864587665038883 0.936455868021718 0.170454545454545 4.4 4 4 increased circulating glucose level 0.330067541818897 0.818179382435981 0.935127561825943 0.170212765957447 4.4 4 4 abnormal tibia morphology 0.439389337897231 0.93577138529055 0.935127561825943 0.170212765957447 4.4 4 4 abnormal innervation 0.439389337897231 0.93577138529055 0.935127561825943 0.170212765957447 4.4 4 4 abnormal pancreatic islet morphology 0.431634353340212 0.92472544593368 0.932922072293334 0.169811320754717 4.4 4 4 abnormal thoracic vertebrae morphology 0.424522559827815 0.911130170467376 0.931165156902951 0.169491525423729 4.4 4 4 abnormal tail morphology 0.438892308338801 0.935513810619337 0.915645737621235 0.166666666666667 4.4 4 4 epidermal hyperplasia 0.446565563022071 0.946194069861501 0.915645737621235 0.166666666666667 4.4 4 4 abnormal long bone epiphyseal plate morphology 0.446565563022071 0.946194069861501 0.915645737621235 0.166666666666667 4.4 4 4 delayed eyelid opening 0.500184612562274 0.972038456053639 0.915645737621235 0.166666666666667 4.4 4 4 abnormal estrous cycle 0.500184612562274 0.972038456053639 0.915645737621235 0.166666666666667 4.4 4 4 abnormal pain threshold 0.500184612562274 0.972038456053639 0.915645737621235 0.166666666666667 4.4 4 4 enhanced paired-pulse facilitation 0.500184612562274 0.972038456053639 0.915645737621235 0.166666666666667 4.4 4 4 abnormal digit morphology 0.431786374051043 0.92472544593368 0.915645737621235 0.166666666666667 4.4 4 4 diluted coat color 0.45492979623411 0.953452332211627 0.915645737621235 0.166666666666667 4.4 4 4 abnormal uterus morphology 0.486299866761718 0.953452332211627 0.915645737621235 0.166666666666667 4.4 4 4 increased heart weight 0.388624552768678 0.864587665038883 0.909058358213888 0.165467625899281 4.4 4 4 circling 0.437358772956393 0.932644618713269 0.904873434825691 0.164705882352941 4.4 4 4 abnormal myocardium layer morphology 0.444319481069748 0.945461684483318 0.904055285246283 0.164556962025316 4.4 4 4 cardiac hypertrophy 0.441812577017182 0.940529555267643 0.896959089914679 0.163265306122449 4.4 4 4 absent kidney 0.488686304443908 0.954165763190127 0.896959089914679 0.163265306122449 4.4 4 4 abnormal epidermis stratum corneum morphology 0.488686304443908 0.954165763190127 0.896959089914679 0.163265306122449 4.4 4 4 decreased urine osmolality 0.488686304443908 0.954165763190127 0.896959089914679 0.163265306122449 4.4 4 4 abnormal male reproductive system morphology 0.50067443981426 0.972610440482603 0.894351650699811 0.162790697674419 4.4 4 4 decreased anxiety-related response 0.433288827964849 0.927543855045234 0.893312914752425 0.16260162601626 4.4 4 4 malocclusion 0.514494839419707 0.997121864477228 0.890898555523364 0.162162162162162 4.4 4 4 abnormal breathing pattern 0.514494839419707 0.997121864477228 0.890898555523364 0.162162162162162 4.4 4 4 impaired skeletal muscle contractility 0.514494839419707 0.997121864477228 0.890898555523364 0.162162162162162 4.4 4 4 abnormal CNS synaptic transmission 0.458969766641972 0.953452332211627 0.887898897087258 0.161616161616162 4.4 4 4 abnormal nose morphology 0.530893209180573 1 0.886108778343131 0.161290322580645 4.4 4 4 decreased neuronal precursor cell number 0.530893209180573 1 0.886108778343131 0.161290322580645 4.4 4 4 abnormal podocyte morphology 0.530893209180573 1 0.886108778343131 0.161290322580645 4.4 4 4 small cranium 0.530893209180573 1 0.886108778343131 0.161290322580645 4.4 4 4 abnormal intestine physiology 0.530893209180573 1 0.886108778343131 0.161290322580645 4.4 4 4 reduced long term potentiation 0.461612665261311 0.953452332211627 0.882944104134763 0.160714285714286 4.4 4 4 short mandible 0.500971503652208 0.972807662244237 0.882944104134763 0.160714285714286 4.4 4 4 increased exploration in new environment 0.482464957063588 0.953452332211627 0.881732932524152 0.160493827160494 4.4 4 4 decreased heart rate 0.476077337913491 0.953452332211627 0.879019908116386 0.16 4.4 4 4 abnormal axon extension 0.512898516139036 0.995191153584909 0.879019908116386 0.16 4.4 4 4 abnormal amino acid level 0.5264202307276 1 0.87402547682027 0.159090909090909 4.4 4 4 abnormal axial skeleton morphology 0.51106057240904 0.992011840708144 0.867453856693802 0.157894736842105 4.4 4 4 increased grooming behavior 0.542075384532767 1 0.867453856693802 0.157894736842105 4.4 4 4 abnormal compact bone morphology 0.542075384532767 1 0.867453856693802 0.157894736842105 4.4 4 4 abnormal cervical vertebrae morphology 0.536717070904884 1 0.861784223643516 0.156862745098039 4.4 4 4 abnormal vertebral body morphology 0.560722035719022 1 0.858417879019908 0.15625 4.4 4 4 abnormal diaphragm morphology 0.560722035719022 1 0.858417879019908 0.15625 4.4 4 4 increased susceptibility to pharmacologically induced seizures 0.518926016470369 1 0.858417879019908 0.15625 4.4 4 4 abnormal depression-related behavior 0.560722035719022 1 0.858417879019908 0.15625 4.4 4 4 irregular heartbeat 0.55164072303618 1 0.854602688446486 0.155555555555556 4.4 4 4 increased circulating corticosterone level 0.55164072303618 1 0.854602688446486 0.155555555555556 4.4 4 4 decreased insulin secretion 0.528426091644258 1 0.854602688446486 0.155555555555556 4.4 4 4 abnormal enzyme/coenzyme level 0.545829465132506 1 0.852497755716323 0.155172413793103 4.4 4 4 abnormal iris morphology 0.568944266253336 1 0.84521145011191 0.153846153846154 4.4 4 4 acanthosis 0.568944266253336 1 0.84521145011191 0.153846153846154 4.4 4 4 abnormal brain wave pattern 0.560073689423905 1 0.845211450111909 0.153846153846154 4.4 4 4 abnormal heart left ventricle morphology 0.561538982298834 1 0.839341926152799 0.152777777777778 4.4 4 4 abnormal neuron differentiation 0.566094621490672 1 0.833891653905054 0.151785714285714 4.4 4 4 abnormal aorta morphology 0.589562619871606 1 0.832405216019305 0.151515151515152 4.4 4 4 enlarged pericardium 0.589562619871606 1 0.832405216019305 0.151515151515152 4.4 4 4 abnormal epidermis stratum basale morphology 0.589562619871606 1 0.832405216019305 0.151515151515152 4.4 4 4 abnormal locomotor coordination 0.589562619871606 1 0.832405216019305 0.151515151515152 4.4 4 4 abnormal middle ear ossicle morphology 0.589562619871606 1 0.832405216019305 0.151515151515152 4.4 4 4 abnormal incisor morphology 0.589035145451812 1 0.824081163859112 0.15 4.4 4 4 abnormal cochlea morphology 0.605164314900466 1 0.813907322329987 0.148148148148148 4.4 4 4 polyphagia 0.605164314900466 1 0.813907322329987 0.148148148148148 4.4 4 4 abnormal long bone morphology 0.609896020855728 1 0.810571636582733 0.147540983606557 4.4 4 4 impaired righting response 0.614583599150619 1 0.809623599580882 0.147368421052632 4.4 4 4 overexpanded pulmonary alveoli 0.61732735911288 1 0.807922709665796 0.147058823529412 4.4 4 4 abnormal bone remodeling 0.61732735911288 1 0.807922709665796 0.147058823529412 4.4 4 4 abnormal skin physiology 0.61732735911288 1 0.807922709665796 0.147058823529412 4.4 4 4 impaired adaptive thermogenesis 0.64394824680713 1 0.784839203675345 0.142857142857143 4.4 4 4 increased fluid intake 0.645900924181776 1 0.784839203675345 0.142857142857143 4.4 4 4 abnormal locomotor activation 0.659902407829462 1 0.784839203675344 0.142857142857143 4.4 4 4 cardiac fibrosis 0.673823387406283 1 0.775605801279164 0.141176470588235 4.4 4 4 abnormal intestinal mucosa morphology 0.66784445551661 1 0.766587129171267 0.13953488372093 4.4 4 4 heart right ventricle hypertrophy 0.669375404878971 1 0.763038114684363 0.138888888888889 4.4 4 4 reduced long term depression 0.669375404878971 1 0.763038114684363 0.138888888888889 4.4 4 4 abnormal limb bone morphology 0.669375404878971 1 0.763038114684363 0.138888888888889 4.4 4 4 short radius 0.669375404878971 1 0.763038114684363 0.138888888888889 4.4 4 4 head tilt 0.669375404878971 1 0.763038114684363 0.138888888888889 4.4 4 4 hypertension 0.69017459627277 1 0.749164694417374 0.136363636363636 4.4 4 4 abnormal photoreceptor outer segment morphology 0.69017459627277 1 0.749164694417374 0.136363636363636 4.4 4 4 syndactyly 0.706412764327282 1 0.744932125522361 0.135593220338983 4.4 4 4 increased brown adipose tissue amount 0.693575493231981 1 0.742415462936137 0.135135135135135 4.4 4 4 abnormal long bone metaphysis morphology 0.693575493231981 1 0.742415462936137 0.135135135135135 4.4 4 4 increased insulin secretion 0.693575493231981 1 0.742415462936137 0.135135135135135 4.4 4 4 abnormal humerus morphology 0.693575493231981 1 0.742415462936137 0.135135135135135 4.4 4 4 rib fusion 0.722540782402359 1 0.73798313181413 0.134328358208955 4.4 4 4 maternal effect 0.722540782402359 1 0.73798313181413 0.134328358208955 4.4 4 4 altered response to myocardial infarction 0.711487499847629 1 0.732516590096988 0.133333333333333 4.4 4 4 abnormal eye physiology 0.724470859538893 1 0.732516590096988 0.133333333333333 4.4 4 4 decreased threshold for auditory brainstem response 0.716530055156104 1 0.722878213911502 0.131578947368421 4.4 4 4 abnormal long bone epiphyseal plate proliferative zone 0.745615781598642 1 0.712168907038739 0.12962962962963 4.4 4 4 increased anxiety-related response 0.820133142566061 1 0.711436975993478 0.129496402877698 4.4 4 4 abnormal social investigation 0.806861108597624 1 0.686734303215927 0.125 4.4 4 4 abnormal hair shaft morphology 0.769250225294622 1 0.686734303215927 0.125 4.4 4 4 decreased cardiac muscle contractility 0.830150282183742 1 0.686734303215926 0.125 4.4 4 4 abnormal spatial learning 0.891187002661507 1 0.674095021561646 0.122699386503067 4.4 4 4 abnormal long bone hypertrophic chondrocyte zone 0.78646175568246 1 0.67271931743601 0.122448979591837 4.4 4 4 short ulna 0.777924403854542 1 0.669984686064319 0.121951219512195 4.4 4 4 abnormal hindlimb morphology 0.802676657051056 1 0.659264931087289 0.12 4.4 4 4 abnormal cartilage morphology 0.795952241292459 1 0.654032669729454 0.119047619047619 4.4 4 4 increased food intake 0.851927381854254 1 0.654032669729454 0.119047619047619 4.4 4 4 abnormal response to novel object 0.817917917592358 1 0.646338167732637 0.117647058823529 4.4 4 4 abnormal axon guidance 0.812808528894544 1 0.638822607642722 0.116279069767442 4.4 4 4 abnormal eye electrophysiology 0.906465232823557 1 0.635654892232924 0.115702479338843 4.4 4 4 abnormal action potential 0.863767284009733 1 0.627871362940276 0.114285714285714 4.4 4 4 abnormal cartilage development 0.843161243961242 1 0.61043049174749 0.111111111111111 4.4 4 4 abnormal autopod morphology 0.843161243961242 1 0.61043049174749 0.111111111111111 4.4 4 4 cardiomyopathy 0.843161243961242 1 0.61043049174749 0.111111111111111 4.4 4 4 abnormal chondrocyte morphology 0.858088995821524 1 0.61043049174749 0.111111111111111 4.4 4 4 abnormal forelimb morphology 0.856745346014158 1 0.597160263666023 0.108695652173913 4.4 4 4 increased systemic arterial blood pressure 0.869331201643031 1 0.584454726141214 0.106382978723404 4.4 4 4 impaired swimming 0.899759071899061 1 0.582683651213513 0.106060606060606 4.4 4 4 decreased compact bone thickness 0.90794569465016 1 0.573986880299879 0.104477611940299 4.4 4 4 abnormal excitatory postsynaptic currents 0.928412377471974 1 0.563474300074606 0.102564102564103 4.4 4 4 abnormal colon morphology 0.908632040269483 1 0.558699094141771 0.101694915254237 4.4 4 4 decreased food intake 0.934233537570335 1 0.556341713997713 0.10126582278481 4.4 4 4 increased percent body fat/body weight 0.919045504555627 1 0.528257156319943 0.0961538461538462 4.4 4 4 short limbs 0.967660104381155 1 0.505183855239302 0.0919540229885057 4.4 4 4 abnormal femur morphology 0.957299277345082 1 0.491988754542753 0.0895522388059701 4.4 4 4 abnormal inhibitory postsynaptic currents 0.961339335544701 1 0.484753625799478 0.0882352941176471 4.4 4 4 decreased susceptibility to injury 0.961339335544701 1 0.484753625799478 0.0882352941176471 4.4 4 4 increased sensitivity to skin irradiation 0.000965490209761557 0.00833908644715928 1.38146718146718 1 5.3 5 3 decreased aerobic running capacity 0.000965490209761557 0.00833908644715928 1.38146718146718 1 5.3 5 3 abnormal ovary development 0.000965490209761557 0.00833908644715928 1.38146718146718 1 5.3 5 3 elevated level of mitotic sister chromatid exchange 0.000965490209761557 0.00833908644715928 1.38146718146718 1 5.3 5 3 tau protein deposits 0.000965490209761557 0.00833908644715928 1.38146718146718 1 5.3 5 3 abnormal olfactory bulb glomerular layer morphology 0.000965490209761557 0.00833908644715928 1.38146718146718 1 5.3 5 3 abnormal anterior commissure pars posterior morphology 0.000965490209761557 0.00833908644715928 1.38146718146718 1 5.3 5 3 increased aorta wall thickness 0.000965490209761557 0.00833908644715928 1.38146718146718 1 5.3 5 3 abnormal heart echocardiography feature 0.000965490209761557 0.00833908644715928 1.38146718146718 1 5.3 5 3 abnormal umbilical vein topology 0.000965490209761557 0.00833908644715928 1.38146718146718 1 5.3 5 3 abnormal AMPA-mediated synaptic currents 2.99707145915372e-05 0.000433442747363074 1.38146718146718 1 5.3 5 3 pale placenta 2.99707145915372e-05 0.000433442747363074 1.38146718146718 1 5.3 5 3 thin hypoglossal nerve 7.14062697725727e-05 0.000920326922586915 1.38146718146718 1 5.3 5 3 decreased effector memory CD4-positive, alpha-beta T cell number 0.000405286122077347 0.00408191239233688 1.38146718146718 1 5.3 5 3 reduced AMPA-mediated synaptic currents 0.000405286122077347 0.00408191239233688 1.38146718146718 1 5.3 5 3 cerebellum atrophy 0.000405286122077347 0.00408191239233688 1.38146718146718 1 5.3 5 3 decreased platelet dense granule number 0.000405286122077347 0.00408191239233688 1.38146718146718 1 5.3 5 3 broad head 0.00229993899736499 0.0171804752430793 1.38146718146718 1 5.3 5 3 increased cell nucleus count 0.00229993899736499 0.0171804752430793 1.38146718146718 1 5.3 5 3 abnormal Purkinje cell innervation 0.00229993899736499 0.0171804752430793 1.38146718146718 1 5.3 5 3 decreased brain cholesterol level 0.00229993899736499 0.0171804752430793 1.38146718146718 1 5.3 5 3 heart block 0.00229993899736499 0.0171804752430793 1.38146718146718 1 5.3 5 3 abnormal outer hair cell kinocilium morphology 0.00229993899736499 0.0171804752430793 1.38146718146718 1 5.3 5 3 abnormal urethra morphology 0.00547856808151034 0.034155233340243 1.38146718146718 1 5.3 5 3 absent ectoplacental cone 0.00547856808151034 0.034155233340243 1.38146718146718 1 5.3 5 3 reduced NMDA-mediated synaptic currents 0.00547856808151034 0.034155233340243 1.38146718146718 1 5.3 5 3 chromatolysis 0.00547856808151034 0.034155233340243 1.38146718146718 1 5.3 5 3 abnormal hippocampal fimbria morphology 0.00547856808151034 0.034155233340243 1.38146718146718 1 5.3 5 3 liver cirrhosis 0.00547856808151034 0.034155233340243 1.38146718146718 1 5.3 5 3 esophageal atresia 0.00547856808151034 0.034155233340243 1.38146718146718 1 5.3 5 3 decreased liver function 0.00547856808151034 0.034155233340243 1.38146718146718 1 5.3 5 3 absent cochlear nerve compound action potential 0.00547856808151034 0.034155233340243 1.38146718146718 1 5.3 5 3 decreased prostate gland weight 0.00547856808151034 0.034155233340243 1.38146718146718 1 5.3 5 3 increased erythrocyte clearance 0.00547856808151034 0.034155233340243 1.38146718146718 1 5.3 5 3 myocardium hypoplasia 0.00547856808151034 0.034155233340243 1.38146718146718 1 5.3 5 3 delayed limb development 0.00547856808151034 0.034155233340243 1.38146718146718 1 5.3 5 3 abnormal platelet alpha-granule morphology 0.00547856808151034 0.034155233340243 1.38146718146718 1 5.3 5 3 decreased hippocampus volume 0.00547856808151034 0.034155233340243 1.38146718146718 1 5.3 5 3 abnormal excitatory synapse morphology 0.00547856808151034 0.034155233340243 1.38146718146718 1 5.3 5 3 abnormal respiratory conducting tube morphology 0.000170120985814333 0.00195914792691275 1.38146718146718 1 5.3 5 3 vascular smooth muscle hyperplasia 0.000170120985814333 0.00195914792691275 1.38146718146718 1 5.3 5 3 abnormal spinal cord dorsal column morphology 0.000170120985814333 0.00195914792691275 1.38146718146718 1 5.3 5 3 thin ventricle myocardium compact layer 0.000170120985814333 0.00195914792691275 1.38146718146718 1 5.3 5 3 abnormal pulmonary trunk morphology 0.0130496875531425 0.0653798545587955 1.38146718146718 1 5.3 5 3 absent lungs 0.0130496875531425 0.0653798545587955 1.38146718146718 1 5.3 5 3 decreased sensitivity to skin irradiation 0.0130496875531425 0.0653798545587955 1.38146718146718 1 5.3 5 3 skin hyperplasia 0.0130496875531425 0.0653798545587955 1.38146718146718 1 5.3 5 3 increased hepatic hemangioma incidence 0.0130496875531425 0.0653798545587955 1.38146718146718 1 5.3 5 3 abnormal oropharynx morphology 0.0130496875531425 0.0653798545587955 1.38146718146718 1 5.3 5 3 improved righting response 0.0130496875531425 0.0653798545587955 1.38146718146718 1 5.3 5 3 increased lysosomal enzyme secretion 0.0130496875531425 0.0653798545587955 1.38146718146718 1 5.3 5 3 enhanced NMDA-mediated synaptic currents 0.0130496875531425 0.0653798545587955 1.38146718146718 1 5.3 5 3 epidermal cyst 0.0130496875531425 0.0653798545587955 1.38146718146718 1 5.3 5 3 sirenomelia 0.0130496875531425 0.0653798545587955 1.38146718146718 1 5.3 5 3 scapular bone foramen 0.0130496875531425 0.0653798545587955 1.38146718146718 1 5.3 5 3 abnormal mesangial cell morphology 0.0130496875531425 0.0653798545587955 1.38146718146718 1 5.3 5 3 abnormal mismatch repair 0.0130496875531425 0.0653798545587955 1.38146718146718 1 5.3 5 3 increased renal carcinoma incidence 0.0130496875531425 0.0653798545587955 1.38146718146718 1 5.3 5 3 aorta hypoplasia 0.0130496875531425 0.0653798545587955 1.38146718146718 1 5.3 5 3 ventricular myocardium compact layer hypoplasia 0.0130496875531425 0.0653798545587955 1.38146718146718 1 5.3 5 3 fused right lung lobes 0.0130496875531425 0.0653798545587955 1.38146718146718 1 5.3 5 3 abnormal nephrogenic mesenchyme morphogenesis 0.0130496875531425 0.0653798545587955 1.38146718146718 1 5.3 5 3 decreased neuronal precursor proliferation 0.0130496875531425 0.0653798545587955 1.38146718146718 1 5.3 5 3 decreased platelet alpha-granule number 0.0130496875531425 0.0653798545587955 1.38146718146718 1 5.3 5 3 small thoracic cage 4.23959555427865e-06 7.72600288737593e-05 1.304719004719 0.944444444444444 5.3 5 3 impaired synaptic plasticity 1.69024707554038e-10 8.24409725569942e-09 1.30020440608676 0.941176470588235 5.3 5 3 abnormal involuntary movement 9.5631829872448e-06 0.000157569067368578 1.30020440608676 0.941176470588235 5.3 5 3 increased cochlear outer hair cell number 2.15019621424402e-05 0.000325143652457873 1.29512548262548 0.9375 5.3 5 3 abnormal voluntary movement 0.000107474393959012 0.00132347799491606 1.28279095421953 0.928571428571429 5.3 5 3 abnormal supraoccipital bone morphology 0.000527197376763964 0.00506333387915197 1.26634491634492 0.916666666666667 5.3 5 3 decreased synaptic depression 0.000527197376763964 0.00506333387915197 1.26634491634492 0.916666666666667 5.3 5 3 prenatal growth retardation 0.000527197376763964 0.00506333387915197 1.26634491634492 0.916666666666667 5.3 5 3 abnormal chondrocyte physiology 1.10069930579856e-06 2.38086045493384e-05 1.26133960047004 0.91304347826087 5.3 5 3 abnormal tail movements 2.40262444244259e-06 4.63296767486507e-05 1.25587925587926 0.909090909090909 5.3 5 3 increased mammary gland tumor incidence 2.40262444244259e-06 4.63296767486507e-05 1.25587925587926 0.909090909090909 5.3 5 3 abnormal sphenoid bone morphology 0.00115726814623193 0.00959568171250646 1.25587925587926 0.909090909090909 5.3 5 3 abnormal proximal-distal axis patterning 0.00115726814623193 0.00959568171250646 1.25587925587926 0.909090909090909 5.3 5 3 abnormal hypothalamus secretion 0.00115726814623193 0.00959568171250646 1.25587925587926 0.909090909090909 5.3 5 3 abnormal spinal cord ventral horn morphology 0.00115726814623193 0.00959568171250646 1.25587925587926 0.909090909090909 5.3 5 3 decreased embryonic cilium length 0.00115726814623193 0.00959568171250646 1.25587925587926 0.909090909090909 5.3 5 3 intestinal hypoperistalsis 0.00252177234844447 0.0184769034366881 1.24332046332046 0.9 5.3 5 3 absent seminal vesicle 0.00252177234844447 0.0184769034366881 1.24332046332046 0.9 5.3 5 3 abnormal hindlimb zeugopod morphology 0.00252177234844447 0.0184769034366881 1.24332046332046 0.9 5.3 5 3 increased heart rate variability 0.00252177234844447 0.0184769034366881 1.24332046332046 0.9 5.3 5 3 abnormal plasma membrane morphology 0.00252177234844447 0.0184769034366881 1.24332046332046 0.9 5.3 5 3 abnormal hippocampus neuron morphology 0.00252177234844447 0.0184769034366881 1.24332046332046 0.9 5.3 5 3 abnormal cerebellar granule cell migration 0.00252177234844447 0.0184769034366881 1.24332046332046 0.9 5.3 5 3 decreased trabecular bone connectivity density 0.00252177234844447 0.0184769034366881 1.24332046332046 0.9 5.3 5 3 abnormal long term depression 2.4346477234603e-05 0.000357322836840692 1.236049583418 0.894736842105263 5.3 5 3 absent corpus callosum 2.61188374114013e-07 6.49706080608607e-06 1.2334528405957 0.892857142857143 5.3 5 3 reduced long term depression 6.2615193681986e-09 2.24108337099194e-07 1.22797082797083 0.888888888888889 5.3 5 3 heart hyperplasia 0.00544712291123524 0.034155233340243 1.22797082797083 0.888888888888889 5.3 5 3 abnormal artery development 0.00544712291123524 0.034155233340243 1.22797082797083 0.888888888888889 5.3 5 3 increased neuronal precursor cell number 0.00544712291123524 0.034155233340243 1.22797082797083 0.888888888888889 5.3 5 3 abnormal ventricle myocardium morphology 0.00544712291123524 0.034155233340243 1.22797082797083 0.888888888888889 5.3 5 3 abnormal lung lobe morphology 0.00544712291123524 0.034155233340243 1.22797082797083 0.888888888888889 5.3 5 3 abnormal coronary sinus connection 0.00544712291123524 0.034155233340243 1.22797082797083 0.888888888888889 5.3 5 3 increased endoplasmic reticulum stress 0.00544712291123524 0.034155233340243 1.22797082797083 0.888888888888889 5.3 5 3 abnormal bone marrow cavity morphology 0.000111042805806406 0.00133117580454667 1.21894163070634 0.882352941176471 5.3 5 3 abnormal dorsal-ventral axis patterning 0.000111042805806406 0.00133117580454667 1.21894163070634 0.882352941176471 5.3 5 3 abnormal touch/ nociception 0.000111042805806406 0.00133117580454667 1.21894163070634 0.882352941176471 5.3 5 3 abnormal glutamate-mediated receptor currents 0.000111042805806406 0.00133117580454667 1.21894163070634 0.882352941176471 5.3 5 3 increased brain size 0.000111042805806406 0.00133117580454667 1.21894163070634 0.882352941176471 5.3 5 3 increased circulating magnesium level 0.000111042805806406 0.00133117580454667 1.21894163070634 0.882352941176471 5.3 5 3 increased trabecular bone mass 0.000111042805806406 0.00133117580454667 1.21894163070634 0.882352941176471 5.3 5 3 abnormal nest building behavior 2.51076035019936e-06 4.82279256457212e-05 1.21569111969112 0.88 5.3 5 3 dystonia 0.000234849648668879 0.00257351762583188 1.20878378378378 0.875 5.3 5 3 embryonic lethality between somite formation and embryo turning, incomplete penetrance 0.000234849648668879 0.00257351762583188 1.20878378378378 0.875 5.3 5 3 abnormal ear pigmentation 0.011641080510589 0.0607068925997698 1.20878378378378 0.875 5.3 5 3 abnormal exoccipital bone morphology 0.011641080510589 0.0607068925997698 1.20878378378378 0.875 5.3 5 3 abnormal vagus ganglion morphology 0.011641080510589 0.0607068925997698 1.20878378378378 0.875 5.3 5 3 dermal cysts 0.011641080510589 0.0607068925997698 1.20878378378378 0.875 5.3 5 3 abnormal hepatobiliary system morphology 0.011641080510589 0.0607068925997698 1.20878378378378 0.875 5.3 5 3 abnormal secondary sex determination 0.011641080510589 0.0607068925997698 1.20878378378378 0.875 5.3 5 3 altered response to CNS ischemic injury 0.011641080510589 0.0607068925997698 1.20878378378378 0.875 5.3 5 3 early eyelid opening 0.011641080510589 0.0607068925997698 1.20878378378378 0.875 5.3 5 3 colon polyps 0.011641080510589 0.0607068925997698 1.20878378378378 0.875 5.3 5 3 increased cardiac output 0.011641080510589 0.0607068925997698 1.20878378378378 0.875 5.3 5 3 abnormal eyelid aperture 0.011641080510589 0.0607068925997698 1.20878378378378 0.875 5.3 5 3 abnormal forelimb zeugopod morphology 0.011641080510589 0.0607068925997698 1.20878378378378 0.875 5.3 5 3 abnormal lateral ganglionic eminence morphology 0.011641080510589 0.0607068925997698 1.20878378378378 0.875 5.3 5 3 accumulation of giant lysosomes in kidney/renal tubule cells 0.011641080510589 0.0607068925997698 1.20878378378378 0.875 5.3 5 3 abnormal somite size 0.011641080510589 0.0607068925997698 1.20878378378378 0.875 5.3 5 3 abnormal olfactory tract morphology 0.011641080510589 0.0607068925997698 1.20878378378378 0.875 5.3 5 3 craniofacial phenotype 0.011641080510589 0.0607068925997698 1.20878378378378 0.875 5.3 5 3 abnormal meiotic spindle morphology 0.011641080510589 0.0607068925997698 1.20878378378378 0.875 5.3 5 3 abnormal base-excision repair 0.011641080510589 0.0607068925997698 1.20878378378378 0.875 5.3 5 3 abnormal olfactory bulb mitral cell layer morphology 0.011641080510589 0.0607068925997698 1.20878378378378 0.875 5.3 5 3 abnormal cerebellum deep nucleus morphology 0.011641080510589 0.0607068925997698 1.20878378378378 0.875 5.3 5 3 increased caudal vertebrae number 0.011641080510589 0.0607068925997698 1.20878378378378 0.875 5.3 5 3 abnormal brain ependyma morphology 0.011641080510589 0.0607068925997698 1.20878378378378 0.875 5.3 5 3 delayed suture closure 0.011641080510589 0.0607068925997698 1.20878378378378 0.875 5.3 5 3 abnormal visual evoked potential 0.011641080510589 0.0607068925997698 1.20878378378378 0.875 5.3 5 3 abnormal foramen magnum morphology 0.011641080510589 0.0607068925997698 1.20878378378378 0.875 5.3 5 3 impaired neuron differentiation 0.011641080510589 0.0607068925997698 1.20878378378378 0.875 5.3 5 3 decreased cranium length 0.011641080510589 0.0607068925997698 1.20878378378378 0.875 5.3 5 3 absent hypoglossal canal 0.011641080510589 0.0607068925997698 1.20878378378378 0.875 5.3 5 3 abnormal synaptic transmission 5.45698908222019e-07 1.27883386958766e-05 1.19727155727156 0.866666666666667 5.3 5 3 abnormal pup retrieval 0.000492950205464 0.0048086809258498 1.19727155727156 0.866666666666667 5.3 5 3 delayed intramembranous bone ossification 0.000492950205464 0.0048086809258498 1.19727155727156 0.866666666666667 5.3 5 3 abnormal trophectoderm morphology 0.000492950205464 0.0048086809258498 1.19727155727156 0.866666666666667 5.3 5 3 abnormal secondary palate development 0.000492950205464 0.0048086809258498 1.19727155727156 0.866666666666667 5.3 5 3 abnormal channel response 2.30867548995896e-05 0.000343882052770833 1.19308529308529 0.863636363636364 5.3 5 3 abnormal cerebral cortex pyramidal cell morphology 2.30867548995896e-05 0.000343882052770833 1.19308529308529 0.863636363636364 5.3 5 3 absent long term depression 1.13216783162764e-06 2.4278167941153e-05 1.19091998402343 0.862068965517241 5.3 5 3 abnormal axon guidance 2.91753897595121e-09 1.10799667216468e-07 1.18870431893688 0.86046511627907 5.3 5 3 myoclonus 2.33718300823832e-06 4.54198651015064e-05 1.18411472697187 0.857142857142857 5.3 5 3 abnormal scapula morphology 4.77921424361609e-05 0.000644641601512043 1.18411472697187 0.857142857142857 5.3 5 3 embryonic lethality at implantation, complete penetrance 4.77921424361609e-05 0.000644641601512043 1.18411472697187 0.857142857142857 5.3 5 3 translucent skin 0.00102586719717226 0.0086945303337853 1.18411472697187 0.857142857142857 5.3 5 3 increased hemangioma incidence 0.00102586719717226 0.0086945303337853 1.18411472697187 0.857142857142857 5.3 5 3 amyloid beta deposits 0.00102586719717226 0.0086945303337853 1.18411472697187 0.857142857142857 5.3 5 3 abnormal vascular endothelial cell migration 0.00102586719717226 0.0086945303337853 1.18411472697187 0.857142857142857 5.3 5 3 increased circulating growth hormone level 0.00102586719717226 0.0086945303337853 1.18411472697187 0.857142857142857 5.3 5 3 spina bifida occulta 0.00102586719717226 0.0086945303337853 1.18411472697187 0.857142857142857 5.3 5 3 testis degeneration 0.00102586719717226 0.0086945303337853 1.18411472697187 0.857142857142857 5.3 5 3 polyphalangy 0.0245503425863824 0.106670702504151 1.18411472697187 0.857142857142857 5.3 5 3 abnormal foot pad morphology 0.0245503425863824 0.106670702504151 1.18411472697187 0.857142857142857 5.3 5 3 skin photosensitivity 0.0245503425863824 0.106670702504151 1.18411472697187 0.857142857142857 5.3 5 3 retina hyperplasia 0.0245503425863824 0.106670702504151 1.18411472697187 0.857142857142857 5.3 5 3 excessive tearing 0.0245503425863824 0.106670702504151 1.18411472697187 0.857142857142857 5.3 5 3 limp posture 0.0245503425863824 0.106670702504151 1.18411472697187 0.857142857142857 5.3 5 3 abnormal circulating free fatty acids level 0.0245503425863824 0.106670702504151 1.18411472697187 0.857142857142857 5.3 5 3 abnormal tumor incidence 0.0245503425863824 0.106670702504151 1.18411472697187 0.857142857142857 5.3 5 3 abnormal adrenal gland physiology 0.0245503425863824 0.106670702504151 1.18411472697187 0.857142857142857 5.3 5 3 abnormal inhibitory postsynaptic potential 0.0245503425863824 0.106670702504151 1.18411472697187 0.857142857142857 5.3 5 3 decreased mortality induced by ionizing radiation 0.0245503425863824 0.106670702504151 1.18411472697187 0.857142857142857 5.3 5 3 absent tunnel of Corti 0.0245503425863824 0.106670702504151 1.18411472697187 0.857142857142857 5.3 5 3 decreased cardiomyocyte apoptosis 0.0245503425863824 0.106670702504151 1.18411472697187 0.857142857142857 5.3 5 3 aorta coarctation 0.0245503425863824 0.106670702504151 1.18411472697187 0.857142857142857 5.3 5 3 increased muscle weight 0.0245503425863824 0.106670702504151 1.18411472697187 0.857142857142857 5.3 5 3 abnormal nephron morphology 0.0245503425863824 0.106670702504151 1.18411472697187 0.857142857142857 5.3 5 3 abnormal optic tract morphology 0.0245503425863824 0.106670702504151 1.18411472697187 0.857142857142857 5.3 5 3 abnormal organ of Corti supporting cell morphology 0.0245503425863824 0.106670702504151 1.18411472697187 0.857142857142857 5.3 5 3 absent deltoid tuberosity 0.0245503425863824 0.106670702504151 1.18411472697187 0.857142857142857 5.3 5 3 abnormal cochlear nerve compound action potential 0.0245503425863824 0.106670702504151 1.18411472697187 0.857142857142857 5.3 5 3 abnormal talus morphology 0.0245503425863824 0.106670702504151 1.18411472697187 0.857142857142857 5.3 5 3 absent fibula 0.0245503425863824 0.106670702504151 1.18411472697187 0.857142857142857 5.3 5 3 enhanced behavioral response to alcohol 0.0245503425863824 0.106670702504151 1.18411472697187 0.857142857142857 5.3 5 3 decreased CD8-positive, naive alpha-beta T cell number 0.0245503425863824 0.106670702504151 1.18411472697187 0.857142857142857 5.3 5 3 decreased areal bone mineral density 0.0245503425863824 0.106670702504151 1.18411472697187 0.857142857142857 5.3 5 3 ductus venosus stenosis 0.0245503425863824 0.106670702504151 1.18411472697187 0.857142857142857 5.3 5 3 fragmented Meckel's cartilage 0.0245503425863824 0.106670702504151 1.18411472697187 0.857142857142857 5.3 5 3 embryo tumor 0.0245503425863824 0.106670702504151 1.18411472697187 0.857142857142857 5.3 5 3 decreased collagen level 0.0245503425863824 0.106670702504151 1.18411472697187 0.857142857142857 5.3 5 3 abnormal contextual conditioning behavior 3.32451171618951e-11 1.94581715153445e-09 1.1805265005265 0.854545454545454 5.3 5 3 decreased paired-pulse facilitation 9.82512022569801e-05 0.0012198913861057 1.1742471042471 0.85 5.3 5 3 decreased myocardial infarction size 9.82512022569801e-05 0.0012198913861057 1.1742471042471 0.85 5.3 5 3 abnormal induced retinal neovascularization 9.82512022569801e-05 0.0012198913861057 1.1742471042471 0.85 5.3 5 3 abnormal locomotor coordination 4.92200044904505e-07 1.16604534447615e-05 1.17215397215397 0.848484848484849 5.3 5 3 abnormal excitatory postsynaptic currents 9.09237548621396e-15 8.86952314586558e-13 1.16893376893377 0.846153846153846 5.3 5 3 abnormal brain wave pattern 2.81314738077959e-10 1.32153304908164e-08 1.16893376893377 0.846153846153846 5.3 5 3 abnormal nerve conduction 9.79654442456632e-06 0.000160321738527031 1.16893376893377 0.846153846153846 5.3 5 3 abnormal tail bud morphology 0.00211407943680936 0.0161808387663486 1.16893376893377 0.846153846153846 5.3 5 3 increased synaptic depression 0.00211407943680936 0.0161808387663486 1.16893376893377 0.846153846153846 5.3 5 3 axonal dystrophy 0.00211407943680936 0.0161808387663486 1.16893376893377 0.846153846153846 5.3 5 3 abnormal vertebral arch development 0.00211407943680936 0.0161808387663486 1.16893376893377 0.846153846153846 5.3 5 3 absent hypoglossal nerve 0.00211407943680936 0.0161808387663486 1.16893376893377 0.846153846153846 5.3 5 3 pancreatic islet hyperplasia 1.0002449468047e-06 2.21165271571261e-05 1.16561293436293 0.84375 5.3 5 3 kyphoscoliosis 0.000200447376938285 0.00226128276704755 1.16334078439342 0.842105263157895 5.3 5 3 increased malignant tumor incidence 0.000200447376938285 0.00226128276704755 1.16334078439342 0.842105263157895 5.3 5 3 abnormal postnatal growth/weight/body size 2.0219934897104e-06 3.99183238544017e-05 1.15864989413377 0.838709677419355 5.3 5 3 preaxial polydactyly 2.0219934897104e-06 3.99183238544017e-05 1.15864989413377 0.838709677419355 5.3 5 3 abnormal CNS synaptic transmission 1.02322892713185e-17 1.41404553124471e-15 1.15819975819976 0.838383838383838 5.3 5 3 abnormal vocalization 2.09170762591454e-07 5.4321813898884e-06 1.1574454763644 0.837837837837838 5.3 5 3 decreased width of hypertrophic chondrocyte zone 2.09170762591454e-07 5.4321813898884e-06 1.1574454763644 0.837837837837838 5.3 5 3 enhanced paired-pulse facilitation 4.06451244865573e-06 7.43417258531701e-05 1.15122265122265 0.833333333333333 5.3 5 3 ocular hypertelorism 4.00480170546303e-05 0.000553441346796626 1.15122265122265 0.833333333333333 5.3 5 3 increased hemangiosarcoma incidence 4.00480170546303e-05 0.000553441346796626 1.15122265122265 0.833333333333333 5.3 5 3 absent spleen 0.000405497422583566 0.00408191239233688 1.15122265122265 0.833333333333333 5.3 5 3 abnormal bile duct morphology 0.000405497422583566 0.00408191239233688 1.15122265122265 0.833333333333333 5.3 5 3 increased gastrointestinal tumor incidence 0.000405497422583566 0.00408191239233688 1.15122265122265 0.833333333333333 5.3 5 3 increased effector memory CD4-positive, alpha-beta T cell number 0.000405497422583566 0.00408191239233688 1.15122265122265 0.833333333333333 5.3 5 3 increased effector memory CD8-positive, alpha-beta T cell number 0.000405497422583566 0.00408191239233688 1.15122265122265 0.833333333333333 5.3 5 3 abnormal adipose tissue distribution 0.00430762199357181 0.0286886471459434 1.15122265122265 0.833333333333333 5.3 5 3 mesocardia 0.00430762199357181 0.0286886471459434 1.15122265122265 0.833333333333333 5.3 5 3 abnormal respiratory function 0.00430762199357181 0.0286886471459434 1.15122265122265 0.833333333333333 5.3 5 3 abnormal corticospinal tract morphology 0.00430762199357181 0.0286886471459434 1.15122265122265 0.833333333333333 5.3 5 3 abnormal aorta elastic fiber morphology 0.00430762199357181 0.0286886471459434 1.15122265122265 0.833333333333333 5.3 5 3 loss of dopaminergic neurons 0.00430762199357181 0.0286886471459434 1.15122265122265 0.833333333333333 5.3 5 3 abnormal vascular endothelial cell development 0.00430762199357181 0.0286886471459434 1.15122265122265 0.833333333333333 5.3 5 3 absent ovary 0.00430762199357181 0.0286886471459434 1.15122265122265 0.833333333333333 5.3 5 3 abnormal palatine bone morphology 0.00430762199357181 0.0286886471459434 1.15122265122265 0.833333333333333 5.3 5 3 abnormal pulmonary valve cusp morphology 0.00430762199357181 0.0286886471459434 1.15122265122265 0.833333333333333 5.3 5 3 abnormal vitelline vein connection 0.00430762199357181 0.0286886471459434 1.15122265122265 0.833333333333333 5.3 5 3 echinocytosis 0.0509052849113033 0.180766447133286 1.15122265122265 0.833333333333333 5.3 5 3 abnormal lacrimal gland physiology 0.0509052849113033 0.180766447133286 1.15122265122265 0.833333333333333 5.3 5 3 jumpy 0.0509052849113033 0.180766447133286 1.15122265122265 0.833333333333333 5.3 5 3 abnormal avoidance learning behavior 0.0509052849113033 0.180766447133286 1.15122265122265 0.833333333333333 5.3 5 3 delayed brain development 0.0509052849113033 0.180766447133286 1.15122265122265 0.833333333333333 5.3 5 3 non-obstructive hydrocephaly 0.0509052849113033 0.180766447133286 1.15122265122265 0.833333333333333 5.3 5 3 abnormal parental behavior 0.0509052849113033 0.180766447133286 1.15122265122265 0.833333333333333 5.3 5 3 increased post-tetanic potentiation 0.0509052849113033 0.180766447133286 1.15122265122265 0.833333333333333 5.3 5 3 decreased posterior semicircular canal size 0.0509052849113033 0.180766447133286 1.15122265122265 0.833333333333333 5.3 5 3 abnormal intestinal peristalsis 0.0509052849113033 0.180766447133286 1.15122265122265 0.833333333333333 5.3 5 3 impaired granulosa cell differentiation 0.0509052849113033 0.180766447133286 1.15122265122265 0.833333333333333 5.3 5 3 abnormal heart left atrium morphology 0.0509052849113033 0.180766447133286 1.15122265122265 0.833333333333333 5.3 5 3 abnormal cholesterol level 0.0509052849113033 0.180766447133286 1.15122265122265 0.833333333333333 5.3 5 3 vestibular saccular degeneration 0.0509052849113033 0.180766447133286 1.15122265122265 0.833333333333333 5.3 5 3 absent parietal bone 0.0509052849113033 0.180766447133286 1.15122265122265 0.833333333333333 5.3 5 3 abnormal immature B cell morphology 0.0509052849113033 0.180766447133286 1.15122265122265 0.833333333333333 5.3 5 3 abnormal ligament morphology 0.0509052849113033 0.180766447133286 1.15122265122265 0.833333333333333 5.3 5 3 abnormal pulmonary respiratory rate 0.0509052849113033 0.180766447133286 1.15122265122265 0.833333333333333 5.3 5 3 abnormal dermis papillary layer morphology 0.0509052849113033 0.180766447133286 1.15122265122265 0.833333333333333 5.3 5 3 decreased platelet ADP level 0.0509052849113033 0.180766447133286 1.15122265122265 0.833333333333333 5.3 5 3 abnormal eyelid development 0.0509052849113033 0.180766447133286 1.15122265122265 0.833333333333333 5.3 5 3 delayed chorioallantoic fusion 0.0509052849113033 0.180766447133286 1.15122265122265 0.833333333333333 5.3 5 3 abnormal olfactory bulb layer morphology 0.0509052849113033 0.180766447133286 1.15122265122265 0.833333333333333 5.3 5 3 ectopic hippocampus pyramidal cells 0.0509052849113033 0.180766447133286 1.15122265122265 0.833333333333333 5.3 5 3 kidney microaneurysm 0.0509052849113033 0.180766447133286 1.15122265122265 0.833333333333333 5.3 5 3 thick myocardium 0.0509052849113033 0.180766447133286 1.15122265122265 0.833333333333333 5.3 5 3 abnormal intestinal enteroendocrine cell morphology 0.0509052849113033 0.180766447133286 1.15122265122265 0.833333333333333 5.3 5 3 increased total lung capacity 0.0509052849113033 0.180766447133286 1.15122265122265 0.833333333333333 5.3 5 3 abnormal ureteric bud tip morphology 0.0509052849113033 0.180766447133286 1.15122265122265 0.833333333333333 5.3 5 3 abnormal endocrine pancreas development 0.0509052849113033 0.180766447133286 1.15122265122265 0.833333333333333 5.3 5 3 increased bone trabecular spacing 0.0509052849113033 0.180766447133286 1.15122265122265 0.833333333333333 5.3 5 3 additional anastomosis between intracranial vertebral arteries 0.0509052849113033 0.180766447133286 1.15122265122265 0.833333333333333 5.3 5 3 abnormal Wolffian duct connection 0.0509052849113033 0.180766447133286 1.15122265122265 0.833333333333333 5.3 5 3 decreased capillary density 0.0509052849113033 0.180766447133286 1.15122265122265 0.833333333333333 5.3 5 3 abnormal cell nucleus morphology 9.23095055321353e-09 3.16398641897367e-07 1.14632383143021 0.829787234042553 5.3 5 3 abnormal cell differentiation 8.75690302625736e-08 2.44750519975451e-06 1.14560693097278 0.829268292682927 5.3 5 3 abnormal liver development 8.38144425712001e-07 1.89765017136246e-05 1.14464423607281 0.828571428571429 5.3 5 3 increased carcinoma incidence 8.38144425712001e-07 1.89765017136246e-05 1.14464423607281 0.828571428571429 5.3 5 3 abnormal pulmonary artery morphology 8.01087452439767e-05 0.00101152539997153 1.14121201947289 0.826086956521739 5.3 5 3 abnormal direction of heart looping 1.6644464608761e-06 3.45737902914323e-05 1.13767885532591 0.823529411764706 5.3 5 3 abnormal adipose tissue morphology 0.00081261491536042 0.00728425081787043 1.13767885532591 0.823529411764706 5.3 5 3 hyperlipidemia 0.00081261491536042 0.00728425081787043 1.13767885532591 0.823529411764706 5.3 5 3 decreased vasoconstriction 0.00081261491536042 0.00728425081787043 1.13767885532591 0.823529411764706 5.3 5 3 absence seizures 0.00081261491536042 0.00728425081787043 1.13767885532591 0.823529411764706 5.3 5 3 enhanced behavioral response to cocaine 0.00081261491536042 0.00728425081787043 1.13767885532591 0.823529411764706 5.3 5 3 abnormal dendritic spine morphology 3.85394824215827e-09 1.40980827240716e-07 1.13767885532591 0.823529411764706 5.3 5 3 abnormal axon extension 7.59960416981433e-09 2.66253737639622e-07 1.13280308880309 0.82 5.3 5 3 abnormal limb posture 0.000158966386350733 0.00185647364341524 1.13029133029133 0.818181818181818 5.3 5 3 increased adenoma incidence 0.000158966386350733 0.00185647364341524 1.13029133029133 0.818181818181818 5.3 5 3 premature suture closure 0.00866204125840086 0.0497043313270407 1.13029133029133 0.818181818181818 5.3 5 3 social withdrawal 0.00866204125840086 0.0497043313270407 1.13029133029133 0.818181818181818 5.3 5 3 abnormal fear/anxiety-related behavior 0.00866204125840086 0.0497043313270407 1.13029133029133 0.818181818181818 5.3 5 3 fatigue 0.00866204125840086 0.0497043313270407 1.13029133029133 0.818181818181818 5.3 5 3 loss of cortex neurons 0.00866204125840086 0.0497043313270407 1.13029133029133 0.818181818181818 5.3 5 3 abnormal radial glial cell morphology 0.00866204125840086 0.0497043313270407 1.13029133029133 0.818181818181818 5.3 5 3 pharyngeal arch hypoplasia 0.00866204125840086 0.0497043313270407 1.13029133029133 0.818181818181818 5.3 5 3 abnormal palatal shelf elevation 0.00866204125840086 0.0497043313270407 1.13029133029133 0.818181818181818 5.3 5 3 common atrioventricular valve 0.00866204125840086 0.0497043313270407 1.13029133029133 0.818181818181818 5.3 5 3 abnormal brain ependyma motile cilium morphology 0.00866204125840086 0.0497043313270407 1.13029133029133 0.818181818181818 5.3 5 3 abnormal brain commissure morphology 3.17862951074527e-05 0.000454416144136716 1.12563992563993 0.814814814814815 5.3 5 3 decreased susceptibility to pharmacologically induced seizures 3.17862951074527e-05 0.000454416144136716 1.12563992563993 0.814814814814815 5.3 5 3 decreased circulating fructosamine level 3.17862951074527e-05 0.000454416144136716 1.12563992563993 0.814814814814815 5.3 5 3 reduced long term potentiation 1.67355023876857e-17 2.19102958891412e-15 1.12244208494209 0.8125 5.3 5 3 abnormal long term potentiation 6.44957050896846e-06 0.000111800046279157 1.12244208494209 0.8125 5.3 5 3 abnormal depression-related behavior 6.44957050896846e-06 0.000111800046279157 1.12244208494209 0.8125 5.3 5 3 increased intestinal adenocarcinoma incidence 0.00161138595157619 0.0126445506452548 1.12244208494209 0.8125 5.3 5 3 loose skin 0.00161138595157619 0.0126445506452548 1.12244208494209 0.8125 5.3 5 3 spina bifida 2.73249461177221e-07 6.76326402665012e-06 1.11833057547343 0.80952380952381 5.3 5 3 abnormal anxiety-related response 0.000312702206495462 0.00330295855056247 1.11833057547343 0.80952380952381 5.3 5 3 trunk curl 0.000312702206495462 0.00330295855056247 1.11833057547343 0.80952380952381 5.3 5 3 decreased vocalization 0.000312702206495462 0.00330295855056247 1.11833057547343 0.80952380952381 5.3 5 3 pulmonary hypoplasia 5.68030240255357e-08 1.66232379133553e-06 1.11693091267559 0.808510638297872 5.3 5 3 abnormal innervation 5.68030240255357e-08 1.66232379133553e-06 1.11693091267559 0.808510638297872 5.3 5 3 pericardial effusion 5.23203993852036e-10 2.32405345483382e-08 1.11408643666708 0.806451612903226 5.3 5 3 abnormal object recognition memory 1.25750081109279e-05 0.000200514953050853 1.11408643666708 0.806451612903226 5.3 5 3 inner cell mass degeneration 1.25750081109279e-05 0.000200514953050853 1.11408643666708 0.806451612903226 5.3 5 3 abnormal pharyngeal arch morphology 2.57138176436583e-06 4.9154026831755e-05 1.11284856284856 0.805555555555556 5.3 5 3 abnormal excitatory postsynaptic potential 1.04670880835461e-12 7.8899641235821e-11 1.11191260947358 0.804878048780488 5.3 5 3 palatal shelves fail to meet at midline 5.30251977116006e-07 1.25023866642281e-05 1.11191260947358 0.804878048780488 5.3 5 3 abnormal maternal nurturing 1.01043219659732e-09 4.08691071387942e-08 1.10970314576872 0.80327868852459 5.3 5 3 abnormal cochlear outer hair cell morphology 0.000120742377298404 0.00144024773526063 1.10517374517375 0.8 5.3 5 3 trabecula carnea hypoplasia 2.12170943920654e-07 5.44098168043944e-06 1.10517374517375 0.8 5.3 5 3 abnormal heart tube morphology 2.43482294852251e-05 0.000357322836840692 1.10517374517375 0.8 5.3 5 3 abnormal pericardium morphology 0.000609232075663508 0.00567589808319467 1.10517374517375 0.8 5.3 5 3 increased mammary adenocarcinoma incidence 0.000609232075663508 0.00567589808319467 1.10517374517375 0.8 5.3 5 3 abnormal dopamine level 0.000609232075663508 0.00567589808319467 1.10517374517375 0.8 5.3 5 3 spleen atrophy 0.000609232075663508 0.00567589808319467 1.10517374517375 0.8 5.3 5 3 abnormal postnatal subventricular zone morphology 0.000609232075663508 0.00567589808319467 1.10517374517375 0.8 5.3 5 3 increased skin tumor incidence 0.000609232075663508 0.00567589808319467 1.10517374517375 0.8 5.3 5 3 hyperpigmentation 0.00315753516400529 0.0226024999150019 1.10517374517375 0.8 5.3 5 3 decreased aggression towards males 0.00315753516400529 0.0226024999150019 1.10517374517375 0.8 5.3 5 3 retarded hair growth 0.0171485251623983 0.080789690040655 1.10517374517375 0.8 5.3 5 3 increased cranium width 0.0171485251623983 0.080789690040655 1.10517374517375 0.8 5.3 5 3 jaundice 0.0171485251623983 0.080789690040655 1.10517374517375 0.8 5.3 5 3 enlarged testis 0.0171485251623983 0.080789690040655 1.10517374517375 0.8 5.3 5 3 alcohol preference 0.0171485251623983 0.080789690040655 1.10517374517375 0.8 5.3 5 3 decreased incidence of induced tumors 0.0171485251623983 0.080789690040655 1.10517374517375 0.8 5.3 5 3 impaired social transmission of food preference 0.0171485251623983 0.080789690040655 1.10517374517375 0.8 5.3 5 3 acrania 0.0171485251623983 0.080789690040655 1.10517374517375 0.8 5.3 5 3 peritoneal inflammation 0.0171485251623983 0.080789690040655 1.10517374517375 0.8 5.3 5 3 increased atrioventricular cushion size 0.0171485251623983 0.080789690040655 1.10517374517375 0.8 5.3 5 3 absent pharyngeal arches 0.0171485251623983 0.080789690040655 1.10517374517375 0.8 5.3 5 3 abnormal reproductive system development 0.0171485251623983 0.080789690040655 1.10517374517375 0.8 5.3 5 3 abnormal deltoid tuberosity morphology 0.0171485251623983 0.080789690040655 1.10517374517375 0.8 5.3 5 3 osteosclerosis 0.0171485251623983 0.080789690040655 1.10517374517375 0.8 5.3 5 3 impaired behavioral response to morphine 0.0171485251623983 0.080789690040655 1.10517374517375 0.8 5.3 5 3 decreased transitional stage T2 B cell number 0.0171485251623983 0.080789690040655 1.10517374517375 0.8 5.3 5 3 thick aortic valve cusps 0.0171485251623983 0.080789690040655 1.10517374517375 0.8 5.3 5 3 increased compact bone area 0.0171485251623983 0.080789690040655 1.10517374517375 0.8 5.3 5 3 abnormal circadian temperature homeostasis 0.0171485251623983 0.080789690040655 1.10517374517375 0.8 5.3 5 3 lethality during fetal growth through weaning, complete penetrance 0.0171485251623983 0.080789690040655 1.10517374517375 0.8 5.3 5 3 abnormal cell morphology 1.467146006279e-16 1.69745380959024e-14 1.10275011853959 0.798245614035088 5.3 5 3 abnormal inhibitory postsynaptic currents 3.16127652814722e-10 1.45623617847522e-08 1.0970474676357 0.794117647058823 5.3 5 3 enlarged liver sinusoidal spaces 9.54273481977639e-06 0.000157569067368578 1.0970474676357 0.794117647058823 5.3 5 3 increased mortality induced by gamma-irradiation 4.67946682567299e-05 0.000636075067150905 1.09564638530156 0.793103448275862 5.3 5 3 embryonic lethality before implantation, complete penetrance 1.88480587375367e-17 2.34422730548113e-15 1.09412200772201 0.792 5.3 5 3 hemolytic anemia 0.000232339512363494 0.00256809438425315 1.09366151866152 0.791666666666667 5.3 5 3 limb grasping 1.19022286716782e-24 3.48315221421171e-22 1.09302897874326 0.791208791208791 5.3 5 3 increased hepatocellular carcinoma incidence 1.35108903526576e-08 4.48111196696478e-07 1.09063198536883 0.789473684210526 5.3 5 3 incomplete somite formation 3.74575197733719e-06 6.92148257192393e-05 1.09063198536883 0.789473684210526 5.3 5 3 decreased total retina thickness 3.74575197733719e-06 6.92148257192393e-05 1.09063198536883 0.789473684210526 5.3 5 3 abnormal stationary movement 0.00117443509375337 0.00972182128356573 1.09063198536883 0.789473684210526 5.3 5 3 abnormal placenta vasculature 6.43013032512445e-08 1.85987781206361e-06 1.08923373923374 0.788461538461538 5.3 5 3 abnormal posture 2.05663589590757e-11 1.24777604660246e-09 1.08790540540541 0.7875 5.3 5 3 increased startle reflex 1.76066393755198e-12 1.25132901276016e-10 1.08654722137868 0.786516853932584 5.3 5 3 abnormal nervous system electrophysiology 8.26044489926466e-12 5.40733070708443e-10 1.08543849972421 0.785714285714286 5.3 5 3 enhanced long term potentiation 2.55631535229762e-08 8.15235184466708e-07 1.08543849972421 0.785714285714286 5.3 5 3 abnormal reproductive system morphology 1.47259453555823e-06 3.09120582886168e-05 1.08543849972421 0.785714285714286 5.3 5 3 shortened head 8.92196549094409e-05 0.00112087824033957 1.08543849972421 0.785714285714286 5.3 5 3 midline facial cleft 0.00610419098214542 0.0373534442019354 1.08543849972421 0.785714285714286 5.3 5 3 abnormal kidney blood vessel morphology 0.00610419098214542 0.0373534442019354 1.08543849972421 0.785714285714286 5.3 5 3 abnormal pinna reflex 0.00610419098214542 0.0373534442019354 1.08543849972421 0.785714285714286 5.3 5 3 abnormal adrenal gland secretion 0.00610419098214542 0.0373534442019354 1.08543849972421 0.785714285714286 5.3 5 3 failure of zygotic cell division 0.00610419098214542 0.0373534442019354 1.08543849972421 0.785714285714286 5.3 5 3 skeletal muscle necrosis 0.00610419098214542 0.0373534442019354 1.08543849972421 0.785714285714286 5.3 5 3 abnormal viscerocranium morphology 0.00610419098214542 0.0373534442019354 1.08543849972421 0.785714285714286 5.3 5 3 multiple persisting craniopharyngeal ducts 0.00610419098214542 0.0373534442019354 1.08543849972421 0.785714285714286 5.3 5 3 abnormal cued conditioning behavior 1.21546204223753e-07 3.35940203340651e-06 1.08350367173897 0.784313725490196 5.3 5 3 abnormal locomotor behavior 1.3308032629803e-12 9.73639151959849e-11 1.08114822897432 0.782608695652174 5.3 5 3 abnormal basicranium morphology 0.000442853894335054 0.00440832511383793 1.08114822897432 0.782608695652174 5.3 5 3 abnormal embryo turning 4.81457200607669e-08 1.43428118145099e-06 1.08005616005616 0.781818181818182 5.3 5 3 kidney cortex cysts 3.44515709750688e-05 0.000486922061366384 1.07927123552124 0.78125 5.3 5 3 increased susceptibility to pharmacologically induced seizures 5.33876859139139e-13 4.28393124873745e-11 1.07927123552124 0.78125 5.3 5 3 short stride length 2.28601578817851e-07 5.74390330615561e-06 1.0775444015444 0.78 5.3 5 3 abnormal spatial learning 7.70770407473843e-21 1.53383311087295e-18 1.07635786531492 0.779141104294479 5.3 5 3 hyperactivity 1.34941510851986e-45 9.5904859498376e-43 1.07612942168198 0.778975741239892 5.3 5 3 abnormal axon morphology 3.44160851462762e-14 3.17074117782823e-12 1.07447447447447 0.777777777777778 5.3 5 3 abnormal motor coordination/ balance 3.99969911422591e-13 3.31641718221232e-11 1.07447447447447 0.777777777777778 5.3 5 3 heart right ventricle hypertrophy 1.33636095316156e-05 0.00021106018228504 1.07447447447447 0.777777777777778 5.3 5 3 abnormal fetal cardiomyocyte proliferation 0.000168654869151883 0.00195914792691275 1.07447447447447 0.777777777777778 5.3 5 3 abnormal mitral valve morphology 0.0022375261400794 0.0168662008286288 1.07447447447447 0.777777777777778 5.3 5 3 underdeveloped hair follicles 0.0022375261400794 0.0168662008286288 1.07447447447447 0.777777777777778 5.3 5 3 abnormal body wall morphology 0.0022375261400794 0.0168662008286288 1.07447447447447 0.777777777777778 5.3 5 3 absent ureter 0.0022375261400794 0.0168662008286288 1.07447447447447 0.777777777777778 5.3 5 3 jerky movement 0.0022375261400794 0.0168662008286288 1.07447447447447 0.777777777777778 5.3 5 3 decreased lactate dehydrogenase level 0.0022375261400794 0.0168662008286288 1.07447447447447 0.777777777777778 5.3 5 3 abnormal hypoglossal nerve topology 0.0022375261400794 0.0168662008286288 1.07447447447447 0.777777777777778 5.3 5 3 abnormal head movements 0.0333199321083272 0.131004846743247 1.07447447447447 0.777777777777778 5.3 5 3 renal tubular acidosis 0.0333199321083272 0.131004846743247 1.07447447447447 0.777777777777778 5.3 5 3 dilated uterus 0.0333199321083272 0.131004846743247 1.07447447447447 0.777777777777778 5.3 5 3 abnormal ion homeostasis 0.0333199321083272 0.131004846743247 1.07447447447447 0.777777777777778 5.3 5 3 abnormal posterior semicircular canal morphology 0.0333199321083272 0.131004846743247 1.07447447447447 0.777777777777778 5.3 5 3 polycythemia 0.0333199321083272 0.131004846743247 1.07447447447447 0.777777777777778 5.3 5 3 abnormal NMDA-mediated synaptic currents 0.0333199321083272 0.131004846743247 1.07447447447447 0.777777777777778 5.3 5 3 abnormal postural reflex 0.0333199321083272 0.131004846743247 1.07447447447447 0.777777777777778 5.3 5 3 decreased circulating bicarbonate level 0.0333199321083272 0.131004846743247 1.07447447447447 0.777777777777778 5.3 5 3 biliary cyst 0.0333199321083272 0.131004846743247 1.07447447447447 0.777777777777778 5.3 5 3 pancreas cysts 0.0333199321083272 0.131004846743247 1.07447447447447 0.777777777777778 5.3 5 3 decreased fear-related response 0.0333199321083272 0.131004846743247 1.07447447447447 0.777777777777778 5.3 5 3 abnormal thymus physiology 0.0333199321083272 0.131004846743247 1.07447447447447 0.777777777777778 5.3 5 3 decreased cellular sensitivity to ionizing radiation 0.0333199321083272 0.131004846743247 1.07447447447447 0.777777777777778 5.3 5 3 decreased vestibular hair cell number 0.0333199321083272 0.131004846743247 1.07447447447447 0.777777777777778 5.3 5 3 small scapula 0.0333199321083272 0.131004846743247 1.07447447447447 0.777777777777778 5.3 5 3 abnormal CNS synapse formation 0.0333199321083272 0.131004846743247 1.07447447447447 0.777777777777778 5.3 5 3 abnormal intervertebral disk development 0.0333199321083272 0.131004846743247 1.07447447447447 0.777777777777778 5.3 5 3 abnormal inguinal fat pad morphology 0.0333199321083272 0.131004846743247 1.07447447447447 0.777777777777778 5.3 5 3 positive geotaxis 0.0333199321083272 0.131004846743247 1.07447447447447 0.777777777777778 5.3 5 3 enhanced conditioned place preference behavior 0.0333199321083272 0.131004846743247 1.07447447447447 0.777777777777778 5.3 5 3 eye opacity 0.0333199321083272 0.131004846743247 1.07447447447447 0.777777777777778 5.3 5 3 decreased transitional stage T1 B cell number 0.0333199321083272 0.131004846743247 1.07447447447447 0.777777777777778 5.3 5 3 abnormal hippocampus granule cell morphology 0.0333199321083272 0.131004846743247 1.07447447447447 0.777777777777778 5.3 5 3 abnormal cerebellar layer morphology 0.0333199321083272 0.131004846743247 1.07447447447447 0.777777777777778 5.3 5 3 abnormal telomere morphology 0.0333199321083272 0.131004846743247 1.07447447447447 0.777777777777778 5.3 5 3 retropulsion 0.0333199321083272 0.131004846743247 1.07447447447447 0.777777777777778 5.3 5 3 abnormal heart left ventricle pressure 0.0333199321083272 0.131004846743247 1.07447447447447 0.777777777777778 5.3 5 3 abnormal ureteric bud invasion 0.0333199321083272 0.131004846743247 1.07447447447447 0.777777777777778 5.3 5 3 increased myeloid cell number 0.0333199321083272 0.131004846743247 1.07447447447447 0.777777777777778 5.3 5 3 enhanced leukocyte tethering or rolling 0.0333199321083272 0.131004846743247 1.07447447447447 0.777777777777778 5.3 5 3 abnormal capillary morphology 6.47135599113866e-05 0.000845013019840284 1.0695229792004 0.774193548387097 5.3 5 3 increased circulating bilirubin level 1.68331472103475e-07 4.5024143748107e-06 1.0686821592482 0.773584905660377 5.3 5 3 atrioventricular septal defect 1.68331472103475e-07 4.5024143748107e-06 1.0686821592482 0.773584905660377 5.3 5 3 intracerebral hemorrhage 0.00083540399498754 0.00746164250460145 1.06749736749737 0.772727272727273 5.3 5 3 abnormal occipital bone morphology 0.00083540399498754 0.00746164250460145 1.06749736749737 0.772727272727273 5.3 5 3 seizures 1.90399068793011e-14 1.8216064754716e-12 1.0663957190273 0.771929824561403 5.3 5 3 decreased brain weight 6.63554288686701e-08 1.90819802671465e-06 1.0663957190273 0.771929824561403 5.3 5 3 abnormal neural tube closure 7.50050543970787e-11 4.05597984375507e-09 1.06522770619156 0.771084337349398 5.3 5 3 kidney cysts 8.78802061633572e-10 3.64336688052252e-08 1.06410309923823 0.77027027027027 5.3 5 3 abnormal heart looping 9.68550469337922e-06 0.00015902767607116 1.06266706266706 0.769230769230769 5.3 5 3 abnormal xiphoid process morphology 0.000315878522346438 0.00332240094856983 1.06266706266706 0.769230769230769 5.3 5 3 ventricular hypoplasia 0.000315878522346438 0.00332240094856983 1.06266706266706 0.769230769230769 5.3 5 3 absent myocardial trabeculae 0.0116194305161133 0.0607068925997698 1.06266706266706 0.769230769230769 5.3 5 3 excessive scratching 0.0116194305161133 0.0607068925997698 1.06266706266706 0.769230769230769 5.3 5 3 abnormal coping response 0.0116194305161133 0.0607068925997698 1.06266706266706 0.769230769230769 5.3 5 3 anal atresia 0.0116194305161133 0.0607068925997698 1.06266706266706 0.769230769230769 5.3 5 3 increased cochlear inner hair cell number 0.0116194305161133 0.0607068925997698 1.06266706266706 0.769230769230769 5.3 5 3 small pituitary gland 0.0116194305161133 0.0607068925997698 1.06266706266706 0.769230769230769 5.3 5 3 abnormal vasculogenesis 3.77029502912841e-06 6.92148257192393e-05 1.06019574391667 0.767441860465116 5.3 5 3 delayed endochondral bone ossification 3.77029502912841e-06 6.92148257192393e-05 1.06019574391667 0.767441860465116 5.3 5 3 abnormal double-strand DNA break repair 3.77029502912841e-06 6.92148257192393e-05 1.06019574391667 0.767441860465116 5.3 5 3 ataxia 7.28056596962209e-24 2.01226753882611e-21 1.06003669865056 0.767326732673267 5.3 5 3 abnormal response to new environment 0.000120547252791675 0.00144024773526063 1.05912483912484 0.766666666666667 5.3 5 3 pallor 1.10574304146708e-20 2.11579678126875e-18 1.05780915609487 0.765714285714286 5.3 5 3 increased sacral vertebrae number 1.90914268910059e-08 6.29005621077844e-07 1.05768581081081 0.765625 5.3 5 3 abnormal trophoblast layer morphology 5.76531546248676e-07 1.33406718259868e-05 1.05641607994549 0.764705882352941 5.3 5 3 abnormal interatrial septum morphology 0.00420739181927742 0.0284399107349255 1.05641607994549 0.764705882352941 5.3 5 3 abnormal testis development 0.00420739181927742 0.0284399107349255 1.05641607994549 0.764705882352941 5.3 5 3 abnormal tarsal bone morphology 0.00420739181927742 0.0284399107349255 1.05641607994549 0.764705882352941 5.3 5 3 decreased anxiety-related response 7.57699402780281e-15 7.5391090576638e-13 1.05575540697492 0.764227642276423 5.3 5 3 decreased circulating total protein level 2.26269002146038e-07 5.74330757998234e-06 1.05493857493858 0.763636363636364 5.3 5 3 left pulmonary isomerism 0.00155812765700126 0.012283291377039 1.052546423975 0.761904761904762 5.3 5 3 abnormal embryonic/fetal subventricular zone morphology 0.00155812765700126 0.012283291377039 1.052546423975 0.761904761904762 5.3 5 3 abnormal erythropoiesis 1.00639869238826e-12 7.70282076097165e-11 1.052546423975 0.761904761904762 5.3 5 3 embryonic lethality, complete penetrance 1.07677705824388e-35 4.86996896796666e-33 1.05234020406434 0.761755485893417 5.3 5 3 failure to gastrulate 2.70775887405863e-06 5.12209140625159e-05 1.05111633372503 0.760869565217391 5.3 5 3 mandible hypoplasia 0.000585730440069617 0.00559310736918684 1.04991505791506 0.76 5.3 5 3 diaphragmatic hernia 0.000585730440069617 0.00559310736918684 1.04991505791506 0.76 5.3 5 3 abnormal vertebrae development 0.000585730440069617 0.00559310736918684 1.04991505791506 0.76 5.3 5 3 pale yolk sac 3.38777465272656e-10 1.54625494470777e-08 1.04858352328232 0.759036144578313 5.3 5 3 abnormal embryonic neuroepithelium morphology 1.62796951286318e-07 4.40171104700779e-06 1.04800958594062 0.758620689655172 5.3 5 3 abnormal calcium ion homeostasis 3.28533979439937e-05 0.000466987585061054 1.045434623813 0.756756756756757 5.3 5 3 abnormal cell cycle 2.1053388252523e-13 1.83755450098775e-11 1.04510995467517 0.756521739130435 5.3 5 3 small liver 1.55651457020549e-09 6.14576189426375e-08 1.04495594495594 0.756410256410256 5.3 5 3 lethality at weaning, incomplete penetrance 1.2724908034507e-05 0.000201612794495772 1.04452396647519 0.75609756097561 5.3 5 3 absent kidney 1.93089666212595e-06 3.8734721347083e-05 1.04314868804665 0.755102040816326 5.3 5 3 anophthalmia 1.75387314099614e-10 8.47137754995708e-09 1.03998091189102 0.752808988764045 5.3 5 3 abnormal embryo size 6.89706421884985e-13 5.44649118869492e-11 1.03915672942222 0.752212389380531 5.3 5 3 abnormal behavior 1.61812657547051e-29 5.75012836640415e-27 1.03858503930446 0.751798561151079 5.3 5 3 decreased exploration in new environment 7.98471489568895e-10 3.33814761395399e-08 1.03610038610039 0.75 5.3 5 3 abnormal forebrain development 1.28987455075231e-08 4.30679589932399e-07 1.03610038610039 0.75 5.3 5 3 pericardial edema 3.26816369129275e-08 1.02258580906802e-06 1.03610038610039 0.75 5.3 5 3 decreased circulating LDL cholesterol level 8.29223266069117e-08 2.33072641169144e-06 1.03610038610039 0.75 5.3 5 3 absent mesoderm 2.10735881054967e-07 5.4321813898884e-06 1.03610038610039 0.75 5.3 5 3 liver hypoplasia 1.36903856259833e-06 2.88600290208758e-05 1.03610038610039 0.75 5.3 5 3 omphalocele 8.98458583128196e-06 0.000150499375456659 1.03610038610039 0.75 5.3 5 3 abnormal spongiotrophoblast layer morphology 0.00015549952672034 0.00182886559204182 1.03610038610039 0.75 5.3 5 3 lymphoid hyperplasia 0.000406960511879215 0.00408191239233688 1.03610038610039 0.75 5.3 5 3 increased bone resorption 0.000406960511879215 0.00408191239233688 1.03610038610039 0.75 5.3 5 3 hypoxia 0.000406960511879215 0.00408191239233688 1.03610038610039 0.75 5.3 5 3 subcutaneous edema 0.000406960511879215 0.00408191239233688 1.03610038610039 0.75 5.3 5 3 abnormal digestive system morphology 0.00107439704024973 0.00901370198185904 1.03610038610039 0.75 5.3 5 3 decreased body height 0.00107439704024973 0.00901370198185904 1.03610038610039 0.75 5.3 5 3 abnormal sensory capabilities/reflexes/nociception 0.00107439704024973 0.00901370198185904 1.03610038610039 0.75 5.3 5 3 absent placental labyrinth 0.00287004414802294 0.0206934342556727 1.03610038610039 0.75 5.3 5 3 abnormal heart right ventricle morphology 0.00287004414802294 0.0206934342556727 1.03610038610039 0.75 5.3 5 3 abnormal response to tactile stimuli 0.00287004414802294 0.0206934342556727 1.03610038610039 0.75 5.3 5 3 abnormal neuron proliferation 0.00287004414802294 0.0206934342556727 1.03610038610039 0.75 5.3 5 3 vasculature congestion 0.00779598280129256 0.045575810148567 1.03610038610039 0.75 5.3 5 3 disorganized yolk sac vascular plexus 0.00779598280129256 0.045575810148567 1.03610038610039 0.75 5.3 5 3 abnormal meiosis 0.00779598280129256 0.045575810148567 1.03610038610039 0.75 5.3 5 3 abnormal epicardium morphology 0.00779598280129256 0.045575810148567 1.03610038610039 0.75 5.3 5 3 impaired muscle relaxation 0.00779598280129256 0.045575810148567 1.03610038610039 0.75 5.3 5 3 impaired behavioral response to addictive substance 0.00779598280129256 0.045575810148567 1.03610038610039 0.75 5.3 5 3 impaired somite development 0.00779598280129256 0.045575810148567 1.03610038610039 0.75 5.3 5 3 decreased fibroblast apoptosis 0.00779598280129256 0.045575810148567 1.03610038610039 0.75 5.3 5 3 abnormal mating frequency 0.021725299052888 0.0990681602090905 1.03610038610039 0.75 5.3 5 3 increased growth rate 0.021725299052888 0.0990681602090905 1.03610038610039 0.75 5.3 5 3 dilated bile duct 0.021725299052888 0.0990681602090905 1.03610038610039 0.75 5.3 5 3 increased osteosarcoma incidence 0.021725299052888 0.0990681602090905 1.03610038610039 0.75 5.3 5 3 abnormal defecation 0.021725299052888 0.0990681602090905 1.03610038610039 0.75 5.3 5 3 abnormal somatic nervous system physiology 0.021725299052888 0.0990681602090905 1.03610038610039 0.75 5.3 5 3 decreased renal glomerular filtration rate 0.021725299052888 0.0990681602090905 1.03610038610039 0.75 5.3 5 3 abnormal thymus corticomedullary boundary morphology 0.021725299052888 0.0990681602090905 1.03610038610039 0.75 5.3 5 3 reduced cerebellar foliation 0.021725299052888 0.0990681602090905 1.03610038610039 0.75 5.3 5 3 decreased red blood cell distribution width 0.021725299052888 0.0990681602090905 1.03610038610039 0.75 5.3 5 3 decreased mammary gland epithelial cell proliferation 0.021725299052888 0.0990681602090905 1.03610038610039 0.75 5.3 5 3 abnormal cecum morphology 0.0632781288137626 0.213285020900047 1.03610038610039 0.75 5.3 5 3 enlarged pituitary gland 0.0632781288137626 0.213285020900047 1.03610038610039 0.75 5.3 5 3 poor grooming 0.0632781288137626 0.213285020900047 1.03610038610039 0.75 5.3 5 3 abnormal erythrocyte cell number 0.0632781288137626 0.213285020900047 1.03610038610039 0.75 5.3 5 3 preneoplasia 0.0632781288137626 0.213285020900047 1.03610038610039 0.75 5.3 5 3 short ureter 0.0632781288137626 0.213285020900047 1.03610038610039 0.75 5.3 5 3 hypospadia 0.0632781288137626 0.213285020900047 1.03610038610039 0.75 5.3 5 3 absent tympanic ring 0.0632781288137626 0.213285020900047 1.03610038610039 0.75 5.3 5 3 abnormal cellular cholesterol metabolism 0.0632781288137626 0.213285020900047 1.03610038610039 0.75 5.3 5 3 calcified muscle 0.0632781288137626 0.213285020900047 1.03610038610039 0.75 5.3 5 3 abnormal neuron apoptosis 0.0632781288137626 0.213285020900047 1.03610038610039 0.75 5.3 5 3 loss of GABAergic neurons 0.0632781288137626 0.213285020900047 1.03610038610039 0.75 5.3 5 3 abnormal platelet shape 0.0632781288137626 0.213285020900047 1.03610038610039 0.75 5.3 5 3 pulmonary interstitial fibrosis 0.0632781288137626 0.213285020900047 1.03610038610039 0.75 5.3 5 3 abnormal extraembryonic tissue physiology 0.0632781288137626 0.213285020900047 1.03610038610039 0.75 5.3 5 3 long femur 0.0632781288137626 0.213285020900047 1.03610038610039 0.75 5.3 5 3 bowed fibula 0.0632781288137626 0.213285020900047 1.03610038610039 0.75 5.3 5 3 absent interparietal bone 0.0632781288137626 0.213285020900047 1.03610038610039 0.75 5.3 5 3 abnormal kidney epithelium morphology 0.0632781288137626 0.213285020900047 1.03610038610039 0.75 5.3 5 3 abnormal vertebral body development 0.0632781288137626 0.213285020900047 1.03610038610039 0.75 5.3 5 3 Sertoli cell hypoplasia 0.0632781288137626 0.213285020900047 1.03610038610039 0.75 5.3 5 3 abnormal ilium morphology 0.0632781288137626 0.213285020900047 1.03610038610039 0.75 5.3 5 3 stomach epithelial hyperplasia 0.0632781288137626 0.213285020900047 1.03610038610039 0.75 5.3 5 3 abnormal frontonasal prominence morphology 0.0632781288137626 0.213285020900047 1.03610038610039 0.75 5.3 5 3 decreased hippocampus pyramidal cell number 0.0632781288137626 0.213285020900047 1.03610038610039 0.75 5.3 5 3 myocardial trabeculae hypoplasia 0.0632781288137626 0.213285020900047 1.03610038610039 0.75 5.3 5 3 sinoatrial block 0.0632781288137626 0.213285020900047 1.03610038610039 0.75 5.3 5 3 abnormal maxillary prominence morphology 0.0632781288137626 0.213285020900047 1.03610038610039 0.75 5.3 5 3 increased cornea thickness 0.0632781288137626 0.213285020900047 1.03610038610039 0.75 5.3 5 3 increased testis apoptosis 0.0632781288137626 0.213285020900047 1.03610038610039 0.75 5.3 5 3 increased mammary gland apoptosis 0.0632781288137626 0.213285020900047 1.03610038610039 0.75 5.3 5 3 decreased basal metabolism 0.0632781288137626 0.213285020900047 1.03610038610039 0.75 5.3 5 3 decreased vascular endothelial cell proliferation 0.0632781288137626 0.213285020900047 1.03610038610039 0.75 5.3 5 3 impaired righting response 8.95432895563643e-11 4.68924068992539e-09 1.03246494614916 0.747368421052632 5.3 5 3 decreased birth body size 1.59280574611287e-12 1.14843602708863e-10 1.030041319515 0.745614035087719 5.3 5 3 abnormal left-right axis patterning 1.62001400068081e-05 0.000249638726759384 1.02806860016162 0.744186046511628 5.3 5 3 decreased startle reflex 1.13305127947226e-12 8.41332853040971e-11 1.02724482724483 0.743589743589744 5.3 5 3 decreased trabecular bone volume 4.17378576833716e-05 0.000575196238157268 1.02724482724483 0.743589743589744 5.3 5 3 domed cranium 4.15462020780446e-08 1.26031923986751e-06 1.02623276337562 0.742857142857143 5.3 5 3 embryonic lethality between somite formation and embryo turning, complete penetrance 4.15462020780446e-08 1.26031923986751e-06 1.02623276337562 0.742857142857143 5.3 5 3 impaired coordination 1.80921718763544e-34 6.92373500652793e-32 1.02611868681233 0.742774566473988 5.3 5 3 ventricular septal defect 2.03048915437582e-14 1.90597802698485e-12 1.02594253917783 0.742647058823529 5.3 5 3 impaired limb coordination 1.72964656332565e-06 3.52663592317423e-05 1.02330902330902 0.740740740740741 5.3 5 3 abnormal apoptosis 1.72964656332565e-06 3.52663592317423e-05 1.02330902330902 0.740740740740741 5.3 5 3 abnormal neuronal precursor proliferation 1.72964656332565e-06 3.52663592317423e-05 1.02330902330902 0.740740740740741 5.3 5 3 axon degeneration 1.72964656332565e-06 3.52663592317423e-05 1.02330902330902 0.740740740740741 5.3 5 3 abnormal atrioventricular cushion morphology 0.000736517531473731 0.00669867407510386 1.02330902330902 0.740740740740741 5.3 5 3 abnormal eye muscle morphology 0.000736517531473731 0.00669867407510386 1.02330902330902 0.740740740740741 5.3 5 3 increased neuron apoptosis 4.58645306553507e-09 1.66551854022168e-07 1.02330902330902 0.740740740740741 5.3 5 3 astrocytosis 2.92669972462673e-08 9.21539944937847e-07 1.02190723012641 0.73972602739726 5.3 5 3 abnormal cell death 1.12976088949469e-05 0.000181895159392754 1.02108443847574 0.739130434782609 5.3 5 3 atrial septal defect 1.12976088949469e-05 0.000181895159392754 1.02108443847574 0.739130434782609 5.3 5 3 embryonic lethality between implantation and placentation, complete penetrance 1.12976088949469e-05 0.000181895159392754 1.02108443847574 0.739130434782609 5.3 5 3 failure of embryo implantation 0.00194762928016958 0.0151397744825682 1.02108443847574 0.739130434782609 5.3 5 3 abnormal Wolffian duct morphology 0.00194762928016958 0.0151397744825682 1.02108443847574 0.739130434782609 5.3 5 3 abnormal ulna morphology 0.00194762928016958 0.0151397744825682 1.02108443847574 0.739130434782609 5.3 5 3 abnormal hematopoietic stem cell physiology 0.00194762928016958 0.0151397744825682 1.02108443847574 0.739130434782609 5.3 5 3 disheveled coat 2.89995845646991e-05 0.000421850681898766 1.01965434822578 0.738095238095238 5.3 5 3 abnormal social investigation 8.14781360335881e-09 2.83464144592378e-07 1.01883204633205 0.7375 5.3 5 3 incomplete embryo turning 1.20915016245487e-06 2.57073592231323e-05 1.01792318634424 0.736842105263158 5.3 5 3 lethality throughout fetal growth and development, complete penetrance 6.641584508325e-19 1.06586719125538e-16 1.01792318634424 0.736842105263158 5.3 5 3 persistence of hyaloid vascular system 7.47115533093098e-05 0.00094577602471709 1.01792318634424 0.736842105263158 5.3 5 3 increased grooming behavior 7.47115533093098e-05 0.00094577602471709 1.01792318634424 0.736842105263158 5.3 5 3 abnormal reproductive system physiology 7.47115533093098e-05 0.00094577602471709 1.01792318634424 0.736842105263158 5.3 5 3 impaired branching involved in ureteric bud morphogenesis 7.47115533093098e-05 0.00094577602471709 1.01792318634424 0.736842105263158 5.3 5 3 small superior vagus ganglion 0.00521418106979231 0.0336890270418399 1.01792318634424 0.736842105263158 5.3 5 3 decreased chemically-elicited antinociception 0.00521418106979231 0.0336890270418399 1.01792318634424 0.736842105263158 5.3 5 3 abnormal digestive system development 0.00521418106979231 0.0336890270418399 1.01792318634424 0.736842105263158 5.3 5 3 abnormal sternebra morphology 0.00521418106979231 0.0336890270418399 1.01792318634424 0.736842105263158 5.3 5 3 abnormal cochlear inner hair cell morphology 0.00521418106979231 0.0336890270418399 1.01792318634424 0.736842105263158 5.3 5 3 abnormal behavioral response to xenobiotic 0.00521418106979231 0.0336890270418399 1.01792318634424 0.736842105263158 5.3 5 3 embryonic lethality between implantation and somite formation, incomplete penetrance 0.00521418106979231 0.0336890270418399 1.01792318634424 0.736842105263158 5.3 5 3 abnormal locomotor activation 9.02488899080379e-10 3.71064650654949e-08 1.01712418855276 0.736263736263736 5.3 5 3 hydrops fetalis 5.19417315461337e-08 1.53815544310723e-06 1.01691334191334 0.736111111111111 5.3 5 3 impaired balance 1.00455841024561e-10 5.0996715213999e-09 1.01578469225528 0.735294117647059 5.3 5 3 increased T cell derived lymphoma incidence 7.85263021037468e-06 0.000132880392165354 1.0149554802616 0.73469387755102 5.3 5 3 abnormal eye morphology 5.64247952810533e-14 5.10387920951345e-12 1.01373850726369 0.733812949640288 5.3 5 3 preweaning lethality, complete penetrance 1.62064237720096e-68 2.68756527552492e-65 1.01369821559011 0.733783783783784 5.3 5 3 epidermal hyperplasia 8.42976257027343e-07 1.89765017136246e-05 1.01307593307593 0.733333333333333 5.3 5 3 abnormal eating behavior 8.42976257027343e-07 1.89765017136246e-05 1.01307593307593 0.733333333333333 5.3 5 3 abnormal optic cup morphology 0.000503077531997389 0.00488830219079494 1.01307593307593 0.733333333333333 5.3 5 3 abnormal brain vasculature morphology 0.000503077531997389 0.00488830219079494 1.01307593307593 0.733333333333333 5.3 5 3 absent incisors 0.0142074944820308 0.0699824604436665 1.01307593307593 0.733333333333333 5.3 5 3 abnormal enteric neuron morphology 0.0142074944820308 0.0699824604436665 1.01307593307593 0.733333333333333 5.3 5 3 audiogenic seizures 0.0142074944820308 0.0699824604436665 1.01307593307593 0.733333333333333 5.3 5 3 abnormal seizure response to electrical stimulation 0.0142074944820308 0.0699824604436665 1.01307593307593 0.733333333333333 5.3 5 3 increased alcohol consumption 0.0142074944820308 0.0699824604436665 1.01307593307593 0.733333333333333 5.3 5 3 abnormal glial cell morphology 0.0142074944820308 0.0699824604436665 1.01307593307593 0.733333333333333 5.3 5 3 abnormal ear development 0.0142074944820308 0.0699824604436665 1.01307593307593 0.733333333333333 5.3 5 3 abnormal placenta size 0.0142074944820308 0.0699824604436665 1.01307593307593 0.733333333333333 5.3 5 3 immune system phenotype 0.0142074944820308 0.0699824604436665 1.01307593307593 0.733333333333333 5.3 5 3 decreased thymocyte apoptosis 0.0142074944820308 0.0699824604436665 1.01307593307593 0.733333333333333 5.3 5 3 abnormal branching involved in lung morphogenesis 0.0142074944820308 0.0699824604436665 1.01307593307593 0.733333333333333 5.3 5 3 heterochrony 0.0142074944820308 0.0699824604436665 1.01307593307593 0.733333333333333 5.3 5 3 decreased brown adipose tissue mass 0.0142074944820308 0.0699824604436665 1.01307593307593 0.733333333333333 5.3 5 3 abnormal gait 7.66772953226101e-29 2.54313029486657e-26 1.01039347252939 0.731391585760518 5.3 5 3 abnormal cornea morphology 2.53869596471578e-08 8.14839511255547e-07 1.00953370953371 0.730769230769231 5.3 5 3 abnormal nasal bone morphology 0.00131818564531825 0.0106407359047127 1.00953370953371 0.730769230769231 5.3 5 3 abnormal ureter morphology 0.00131818564531825 0.0106407359047127 1.00953370953371 0.730769230769231 5.3 5 3 thick skin 0.00131818564531825 0.0106407359047127 1.00953370953371 0.730769230769231 5.3 5 3 decreased bone resorption 0.00131818564531825 0.0106407359047127 1.00953370953371 0.730769230769231 5.3 5 3 increased thymocyte apoptosis 0.00131818564531825 0.0106407359047127 1.00953370953371 0.730769230769231 5.3 5 3 embryonic lethality between implantation and somite formation, complete penetrance 4.66845351424264e-23 1.22239769649248e-20 1.00931683870459 0.730612244897959 5.3 5 3 abnormal respiratory electron transport chain 0.000132617591984257 0.00156715562974271 1.00809767296254 0.72972972972973 5.3 5 3 abnormal lung development 7.04053681256416e-09 2.48416103847565e-07 1.00765841471724 0.729411764705882 5.3 5 3 overriding aortic valve 1.38737496154428e-05 0.000215693451052587 1.00731981981982 0.729166666666667 5.3 5 3 vertebral transformation 1.38737496154428e-05 0.000215693451052587 1.00731981981982 0.729166666666667 5.3 5 3 infertility 8.68232110489972e-11 4.59516462732724e-09 1.00705084256486 0.728971962616822 5.3 5 3 abnormal thoracic vertebrae morphology 1.48490071668181e-06 3.1039416241563e-05 1.00683201361167 0.728813559322034 5.3 5 3 preweaning lethality, incomplete penetrance 4.50962060218407e-37 2.24353624958657e-34 1.00654577035995 0.728606356968215 5.3 5 3 abnormal action potential 1.61291795613048e-07 4.38484526325091e-06 1.00649751792609 0.728571428571429 5.3 5 3 abnormal neural tube morphology 1.5437853331502e-15 1.63411319838772e-13 1.00625387292054 0.728395061728395 5.3 5 3 abnormal head morphology 3.7657035393002e-06 6.92148257192393e-05 1.0047034047034 0.727272727272727 5.3 5 3 abnormal learning/memory/conditioning 3.7657035393002e-06 6.92148257192393e-05 1.0047034047034 0.727272727272727 5.3 5 3 increased mean corpuscular hemoglobin 5.44474650072461e-10 2.39713396823938e-08 1.0047034047034 0.727272727272727 5.3 5 3 abnormal vascular development 4.07056330939846e-07 9.83060799235794e-06 1.0047034047034 0.727272727272727 5.3 5 3 decreased blood urea nitrogen level 3.54416178082116e-05 0.00049668182703057 1.0047034047034 0.727272727272727 5.3 5 3 lethality, incomplete penetrance 3.54416178082116e-05 0.00049668182703057 1.0047034047034 0.727272727272727 5.3 5 3 embryonic lethality, incomplete penetrance 3.54416178082116e-05 0.00049668182703057 1.0047034047034 0.727272727272727 5.3 5 3 enlarged pericardium 0.000342850275173487 0.00357584930605471 1.0047034047034 0.727272727272727 5.3 5 3 increased cardiomyocyte apoptosis 0.000342850275173487 0.00357584930605471 1.0047034047034 0.727272727272727 5.3 5 3 abnormal QRS complex 0.000342850275173487 0.00357584930605471 1.0047034047034 0.727272727272727 5.3 5 3 increased body size 0.00348539075570449 0.024377344758254 1.0047034047034 0.727272727272727 5.3 5 3 abnormal oogenesis 0.00348539075570449 0.024377344758254 1.0047034047034 0.727272727272727 5.3 5 3 increased myocardial infarction size 0.00348539075570449 0.024377344758254 1.0047034047034 0.727272727272727 5.3 5 3 increased coping response 0.00348539075570449 0.024377344758254 1.0047034047034 0.727272727272727 5.3 5 3 aphakia 0.00348539075570449 0.024377344758254 1.0047034047034 0.727272727272727 5.3 5 3 decreased cardiac output 0.00348539075570449 0.024377344758254 1.0047034047034 0.727272727272727 5.3 5 3 abnormal mesenteric lymph node morphology 0.00348539075570449 0.024377344758254 1.0047034047034 0.727272727272727 5.3 5 3 embryonic lethality before implantation, incomplete penetrance 0.00348539075570449 0.024377344758254 1.0047034047034 0.727272727272727 5.3 5 3 enlarged cranium 0.0397791489063916 0.150609791331277 1.0047034047034 0.727272727272727 5.3 5 3 abnormal glossopharyngeal ganglion morphology 0.0397791489063916 0.150609791331277 1.0047034047034 0.727272727272727 5.3 5 3 abnormal hemoglobin 0.0397791489063916 0.150609791331277 1.0047034047034 0.727272727272727 5.3 5 3 secondary sex reversal 0.0397791489063916 0.150609791331277 1.0047034047034 0.727272727272727 5.3 5 3 abnormal primary sex determination 0.0397791489063916 0.150609791331277 1.0047034047034 0.727272727272727 5.3 5 3 decreased post-tetanic potentiation 0.0397791489063916 0.150609791331277 1.0047034047034 0.727272727272727 5.3 5 3 pulmonary hypertension 0.0397791489063916 0.150609791331277 1.0047034047034 0.727272727272727 5.3 5 3 abnormal ureter development 0.0397791489063916 0.150609791331277 1.0047034047034 0.727272727272727 5.3 5 3 increased circulating triiodothyronine level 0.0397791489063916 0.150609791331277 1.0047034047034 0.727272727272727 5.3 5 3 abnormal platelet aggregation 0.0397791489063916 0.150609791331277 1.0047034047034 0.727272727272727 5.3 5 3 enhanced behavioral response to addictive substance 0.0397791489063916 0.150609791331277 1.0047034047034 0.727272727272727 5.3 5 3 abnormal aorta smooth muscle morphology 0.0397791489063916 0.150609791331277 1.0047034047034 0.727272727272727 5.3 5 3 abnormal pulmonary alveolar sac morphology 0.0397791489063916 0.150609791331277 1.0047034047034 0.727272727272727 5.3 5 3 decreased core body temperature 0.0397791489063916 0.150609791331277 1.0047034047034 0.727272727272727 5.3 5 3 reduced sympathetic cervical ganglion size 0.0397791489063916 0.150609791331277 1.0047034047034 0.727272727272727 5.3 5 3 abnormal brain morphology 2.69537170047428e-15 2.7936404603874e-13 1.00392335547615 0.726708074534162 5.3 5 3 abnormal fertility/fecundity 1.1202977744078e-07 3.11367677523955e-06 1.0029830221611 0.726027397260274 5.3 5 3 abnormal extraembryonic tissue morphology 3.79578334297394e-10 1.71672928466322e-08 1.00224089635854 0.725490196078431 5.3 5 3 abnormal response to novel object 9.56499665232375e-06 0.000157569067368578 1.00224089635854 0.725490196078431 5.3 5 3 increased grip strength 3.4170613094859e-09 1.26864776229047e-07 1.00194323051466 0.725274725274725 5.3 5 3 increased bone mineral content 1.05785062134537e-10 5.31596650625575e-09 1.00124685629273 0.724770642201835 5.3 5 3 abnormal sternum morphology 2.82123191792598e-07 6.94833108499097e-06 1.00106317497622 0.72463768115942 5.3 5 3 decreased cell proliferation 4.16660183627496e-17 4.93543907987332e-15 1.00063028279244 0.724324324324324 5.3 5 3 lordosis 0.000891024121540003 0.00787361457311104 1.00037278657968 0.724137931034483 5.3 5 3 increased cellular sensitivity to gamma-irradiation 2.43395279353668e-05 0.000357322836840692 0.99935923765711 0.723404255319149 5.3 5 3 neuron degeneration 2.43395279353668e-05 0.000357322836840692 0.99935923765711 0.723404255319149 5.3 5 3 decreased bone trabecula number 2.43395279353668e-05 0.000357322836840692 0.99935923765711 0.723404255319149 5.3 5 3 embryonic lethality during organogenesis, complete penetrance 1.34719232044613e-48 1.11704696570325e-45 0.999096800882515 0.723214285714286 5.3 5 3 increased cell proliferation 6.58402145958474e-06 0.00011295002331529 0.997726297726298 0.722222222222222 5.3 5 3 abnormal maxilla morphology 6.58402145958474e-06 0.00011295002331529 0.997726297726298 0.722222222222222 5.3 5 3 neurodegeneration 6.58402145958474e-06 0.00011295002331529 0.997726297726298 0.722222222222222 5.3 5 3 abnormal reflex 0.000233322344056768 0.00256809438425315 0.997726297726298 0.722222222222222 5.3 5 3 abnormal trophoblast giant cell morphology 0.000233322344056768 0.00256809438425315 0.997726297726298 0.722222222222222 5.3 5 3 abnormal heart shape 0.00932904258519223 0.0525617065247241 0.997726297726298 0.722222222222222 5.3 5 3 blepharoptosis 0.00932904258519223 0.0525617065247241 0.997726297726298 0.722222222222222 5.3 5 3 acidosis 0.00932904258519223 0.0525617065247241 0.997726297726298 0.722222222222222 5.3 5 3 decreased cellular sensitivity to gamma-irradiation 0.00932904258519223 0.0525617065247241 0.997726297726298 0.722222222222222 5.3 5 3 absent inner cell mass 0.00932904258519223 0.0525617065247241 0.997726297726298 0.722222222222222 5.3 5 3 darkened coat color 0.00932904258519223 0.0525617065247241 0.997726297726298 0.722222222222222 5.3 5 3 abnormal pregnancy 0.00932904258519223 0.0525617065247241 0.997726297726298 0.722222222222222 5.3 5 3 atrioventricular block 0.00932904258519223 0.0525617065247241 0.997726297726298 0.722222222222222 5.3 5 3 abnormal aerobic respiration 0.00932904258519223 0.0525617065247241 0.997726297726298 0.722222222222222 5.3 5 3 abnormal metanephric mesenchyme morphology 0.00932904258519223 0.0525617065247241 0.997726297726298 0.722222222222222 5.3 5 3 increased adipocyte glucose uptake 0.00932904258519223 0.0525617065247241 0.997726297726298 0.722222222222222 5.3 5 3 decreased embryo size 2.99288178859734e-41 1.86119836228397e-38 0.997084053569409 0.721757322175732 5.3 5 3 abnormal testis morphology 5.1242602040624e-11 2.89695392218301e-09 0.997058922276313 0.721739130434783 5.3 5 3 hydroencephaly 5.1242602040624e-11 2.89695392218301e-09 0.997058922276313 0.721739130434783 5.3 5 3 abnormal male reproductive system morphology 6.20648163392513e-05 0.00081255910865204 0.995941456406573 0.720930232558139 5.3 5 3 decreased mean corpuscular hemoglobin 4.90936192681733e-07 1.16604534447615e-05 0.995468998410175 0.720588235294118 5.3 5 3 ruffled hair 0.00233096829785576 0.0173083093758693 0.994656370656371 0.72 5.3 5 3 abnormal egg cylinder morphology 0.00233096829785576 0.0173083093758693 0.994656370656371 0.72 5.3 5 3 increased cellular sensitivity to ionizing radiation 0.00233096829785576 0.0173083093758693 0.994656370656371 0.72 5.3 5 3 reduced fertility 7.76136548891118e-13 6.0332489542708e-11 0.993861281631066 0.719424460431655 5.3 5 3 absent vitelline blood vessels 4.52635925267485e-06 8.129471942981e-05 0.99368692000271 0.719298245614035 5.3 5 3 abnormal craniofacial bone morphology 4.52635925267485e-06 8.129471942981e-05 0.99368692000271 0.719298245614035 5.3 5 3 abnormal facial morphology 4.52635925267485e-06 8.129471942981e-05 0.99368692000271 0.719298245614035 5.3 5 3 abnormal auditory brainstem response waveform shape 0.000601969191083579 0.00567196349553183 0.992929536679537 0.71875 5.3 5 3 increased fibroblast apoptosis 0.000601969191083579 0.00567196349553183 0.992929536679537 0.71875 5.3 5 3 retinal degeneration 2.8560219318313e-09 1.09297762391236e-07 0.992929536679537 0.71875 5.3 5 3 abnormal craniofacial morphology 7.93400670434986e-10 3.33814761395399e-08 0.99251040221914 0.718446601941748 5.3 5 3 abnormal ovary morphology 3.3861813343695e-07 8.21768396999427e-06 0.992321496546849 0.71830985915493 5.3 5 3 failure of heart looping 0.000158644596720789 0.00185647364341524 0.991822591822592 0.717948717948718 5.3 5 3 decreased grip strength 4.50053601953557e-19 7.72074713696189e-17 0.990366883517568 0.71689497716895 5.3 5 3 rib fusion 8.49762078584538e-07 1.90430916259373e-05 0.989707831498876 0.716417910447761 5.3 5 3 abnormal intestine morphology 2.33335577339395e-07 5.83338943348487e-06 0.989429197537306 0.716216216216216 5.3 5 3 lethality throughout fetal growth and development, incomplete penetrance 1.1070453912703e-15 1.19729365686299e-13 0.987864800155303 0.715083798882682 5.3 5 3 abnormal cartilage morphology 0.00010781183802832 0.0013243552942985 0.986762272476558 0.714285714285714 5.3 5 3 abnormal eye pigmentation 0.00614983537557721 0.0375404061269897 0.986762272476558 0.714285714285714 5.3 5 3 absent segment of posterior cerebral artery 0.00614983537557721 0.0375404061269897 0.986762272476558 0.714285714285714 5.3 5 3 abnormal somite shape 0.00156041008046003 0.012283291377039 0.986762272476558 0.714285714285714 5.3 5 3 failure of blastocyst to hatch from the zona pellucida 0.00156041008046003 0.012283291377039 0.986762272476558 0.714285714285714 5.3 5 3 abnormal hormone level 0.00156041008046003 0.012283291377039 0.986762272476558 0.714285714285714 5.3 5 3 prolonged QRS complex duration 0.00156041008046003 0.012283291377039 0.986762272476558 0.714285714285714 5.3 5 3 abnormal placing response 0.0254075293510329 0.109250180225919 0.986762272476558 0.714285714285714 5.3 5 3 increased lactate dehydrogenase level 0.0254075293510329 0.109250180225919 0.986762272476558 0.714285714285714 5.3 5 3 absent olfactory bulb 0.0254075293510329 0.109250180225919 0.986762272476558 0.714285714285714 5.3 5 3 vascular smooth muscle hypoplasia 0.0254075293510329 0.109250180225919 0.986762272476558 0.714285714285714 5.3 5 3 abnormal pancreas development 0.0254075293510329 0.109250180225919 0.986762272476558 0.714285714285714 5.3 5 3 decreased CNS synapse formation 0.0254075293510329 0.109250180225919 0.986762272476558 0.714285714285714 5.3 5 3 lysosomal protein accumulation 0.0254075293510329 0.109250180225919 0.986762272476558 0.714285714285714 5.3 5 3 decreased tongue size 0.0254075293510329 0.109250180225919 0.986762272476558 0.714285714285714 5.3 5 3 pulmonary alveolar hemorrhage 0.0254075293510329 0.109250180225919 0.986762272476558 0.714285714285714 5.3 5 3 abnormal renal tubule epithelial cell primary cilium morphology 0.0254075293510329 0.109250180225919 0.986762272476558 0.714285714285714 5.3 5 3 decreased response to antigen 0.0254075293510329 0.109250180225919 0.986762272476558 0.714285714285714 5.3 5 3 growth retardation of molars 0.116792640723605 0.317163421179005 0.986762272476558 0.714285714285714 5.3 5 3 cellular necrosis 0.116792640723605 0.317163421179005 0.986762272476558 0.714285714285714 5.3 5 3 mammary gland hyperplasia 0.116792640723605 0.317163421179005 0.986762272476558 0.714285714285714 5.3 5 3 small L4 dorsal root ganglion 0.116792640723605 0.317163421179005 0.986762272476558 0.714285714285714 5.3 5 3 abnormal oculomotor nerve morphology 0.116792640723605 0.317163421179005 0.986762272476558 0.714285714285714 5.3 5 3 abnormal circulating alanine transaminase level 0.116792640723605 0.317163421179005 0.986762272476558 0.714285714285714 5.3 5 3 absent amniotic folds 0.116792640723605 0.317163421179005 0.986762272476558 0.714285714285714 5.3 5 3 increased chemically-elicited antinociception 0.116792640723605 0.317163421179005 0.986762272476558 0.714285714285714 5.3 5 3 abnormal gastrulation movements 0.116792640723605 0.317163421179005 0.986762272476558 0.714285714285714 5.3 5 3 abnormal sinus venosus morphology 0.116792640723605 0.317163421179005 0.986762272476558 0.714285714285714 5.3 5 3 abnormal prostate gland physiology 0.116792640723605 0.317163421179005 0.986762272476558 0.714285714285714 5.3 5 3 anuria 0.116792640723605 0.317163421179005 0.986762272476558 0.714285714285714 5.3 5 3 abnormal central pattern generator function 0.116792640723605 0.317163421179005 0.986762272476558 0.714285714285714 5.3 5 3 absent vestibular hair cells 0.116792640723605 0.317163421179005 0.986762272476558 0.714285714285714 5.3 5 3 increased adrenocorticotropin level 0.116792640723605 0.317163421179005 0.986762272476558 0.714285714285714 5.3 5 3 abnormal renal filtration rate 0.116792640723605 0.317163421179005 0.986762272476558 0.714285714285714 5.3 5 3 absent popliteal lymph nodes 0.116792640723605 0.317163421179005 0.986762272476558 0.714285714285714 5.3 5 3 abnormal uterus physiology 0.116792640723605 0.317163421179005 0.986762272476558 0.714285714285714 5.3 5 3 abnormal spinal cord central canal morphology 0.116792640723605 0.317163421179005 0.986762272476558 0.714285714285714 5.3 5 3 decreased behavioral withdrawal response 0.116792640723605 0.317163421179005 0.986762272476558 0.714285714285714 5.3 5 3 abnormal cerebellum white matter morphology 0.116792640723605 0.317163421179005 0.986762272476558 0.714285714285714 5.3 5 3 decreased DN2 thymocyte number 0.116792640723605 0.317163421179005 0.986762272476558 0.714285714285714 5.3 5 3 decreased DN4 thymocyte number 0.116792640723605 0.317163421179005 0.986762272476558 0.714285714285714 5.3 5 3 arteritis 0.116792640723605 0.317163421179005 0.986762272476558 0.714285714285714 5.3 5 3 increased oligodendrocyte number 0.116792640723605 0.317163421179005 0.986762272476558 0.714285714285714 5.3 5 3 focal dorsal hair loss 0.116792640723605 0.317163421179005 0.986762272476558 0.714285714285714 5.3 5 3 abnormal retina inner limiting membrane morphology 0.116792640723605 0.317163421179005 0.986762272476558 0.714285714285714 5.3 5 3 decreased skeletal muscle glycogen level 0.116792640723605 0.317163421179005 0.986762272476558 0.714285714285714 5.3 5 3 abnormal T wave 0.116792640723605 0.317163421179005 0.986762272476558 0.714285714285714 5.3 5 3 long stride length 0.116792640723605 0.317163421179005 0.986762272476558 0.714285714285714 5.3 5 3 abnormal conotruncal ridge morphology 0.116792640723605 0.317163421179005 0.986762272476558 0.714285714285714 5.3 5 3 thick pulmonary valve 0.116792640723605 0.317163421179005 0.986762272476558 0.714285714285714 5.3 5 3 altered tumor pathology 0.116792640723605 0.317163421179005 0.986762272476558 0.714285714285714 5.3 5 3 abnormal impulsive behavior control 0.116792640723605 0.317163421179005 0.986762272476558 0.714285714285714 5.3 5 3 increased compact bone volume 0.116792640723605 0.317163421179005 0.986762272476558 0.714285714285714 5.3 5 3 small lung lobe 0.116792640723605 0.317163421179005 0.986762272476558 0.714285714285714 5.3 5 3 small tail bud 0.116792640723605 0.317163421179005 0.986762272476558 0.714285714285714 5.3 5 3 decreased volumetric bone mineral density 0.116792640723605 0.317163421179005 0.986762272476558 0.714285714285714 5.3 5 3 polydactyly 3.40090797724782e-09 1.26864776229047e-07 0.986762272476558 0.714285714285714 5.3 5 3 increased fluid intake 2.89265481281133e-05 0.000421850681898766 0.986762272476558 0.714285714285714 5.3 5 3 ovary cysts 0.000406649716681522 0.00408191239233688 0.986762272476558 0.714285714285714 5.3 5 3 abnormal artery morphology 0.000406649716681522 0.00408191239233688 0.986762272476558 0.714285714285714 5.3 5 3 holoprosencephaly 0.000406649716681522 0.00408191239233688 0.986762272476558 0.714285714285714 5.3 5 3 impaired behavioral response to xenobiotic 0.000406649716681522 0.00408191239233688 0.986762272476558 0.714285714285714 5.3 5 3 abnormal hippocampus pyramidal cell morphology 0.000406649716681522 0.00408191239233688 0.986762272476558 0.714285714285714 5.3 5 3 kyphosis 3.08715551826772e-13 2.64803425920378e-11 0.985446589446589 0.713333333333333 5.3 5 3 abnormal motor capabilities/coordination/movement 9.77235426835497e-12 6.31395616689169e-10 0.983772083772084 0.712121212121212 5.3 5 3 syndactyly 5.35635781781846e-06 9.44960288781802e-05 0.983417315620706 0.711864406779661 5.3 5 3 embryonic growth arrest 3.05757189055993e-19 5.43265005554845e-17 0.983315068031225 0.7117903930131 5.3 5 3 distended pericardium 1.97308490217127e-05 0.000299271261838478 0.982967032967033 0.711538461538462 5.3 5 3 absent corpus luteum 1.97308490217127e-05 0.000299271261838478 0.982967032967033 0.711538461538462 5.3 5 3 abnormal ovarian follicle morphology 7.32460277902494e-05 0.000936758324566814 0.982376662376662 0.711111111111111 5.3 5 3 abnormal cell migration 7.32460277902494e-05 0.000936758324566814 0.982376662376662 0.711111111111111 5.3 5 3 lethality at weaning, complete penetrance 7.32460277902494e-05 0.000936758324566814 0.982376662376662 0.711111111111111 5.3 5 3 anemia 9.59820210622408e-18 1.36431587081328e-15 0.982085674028802 0.710900473933649 5.3 5 3 decreased neuron apoptosis 0.000274750596004582 0.00296504168139435 0.981568786831945 0.710526315789474 5.3 5 3 abnormal bone structure 3.01026956542382e-16 3.40365706545079e-14 0.980626963010383 0.709844559585492 5.3 5 3 increased tumor incidence 5.97606635558705e-11 3.30343667989395e-09 0.980396064267032 0.709677419354839 5.3 5 3 increased lung adenoma incidence 0.00104576476175822 0.00881810116906299 0.980396064267032 0.709677419354839 5.3 5 3 abnormal retinal photoreceptor layer morphology 0.00104576476175822 0.00881810116906299 0.980396064267032 0.709677419354839 5.3 5 3 pale kidney 0.00104576476175822 0.00881810116906299 0.980396064267032 0.709677419354839 5.3 5 3 abnormal somite development 1.89106468970597e-07 5.00428022940808e-06 0.979267875470407 0.708860759493671 5.3 5 3 abnormal nervous system morphology 1.89106468970597e-07 5.00428022940808e-06 0.979267875470407 0.708860759493671 5.3 5 3 prenatal lethality, complete penetrance 1.42514333486164e-22 3.37623242425555e-20 0.9789533624066 0.70863309352518 5.3 5 3 curly tail 4.97564181408968e-05 0.000667218814692618 0.978539253539254 0.708333333333333 5.3 5 3 thymus atrophy 4.97564181408968e-05 0.000667218814692618 0.978539253539254 0.708333333333333 5.3 5 3 abnormal nursing 0.00406833614854634 0.0276880606552914 0.978539253539254 0.708333333333333 5.3 5 3 increased stereotypic behavior 0.00406833614854634 0.0276880606552914 0.978539253539254 0.708333333333333 5.3 5 3 abnormal startle reflex 0.00406833614854634 0.0276880606552914 0.978539253539254 0.708333333333333 5.3 5 3 abnormal impulse conducting system conduction 0.00406833614854634 0.0276880606552914 0.978539253539254 0.708333333333333 5.3 5 3 abnormal tumor morphology 0.00406833614854634 0.0276880606552914 0.978539253539254 0.708333333333333 5.3 5 3 abnormal lung saccule morphology 0.00406833614854634 0.0276880606552914 0.978539253539254 0.708333333333333 5.3 5 3 decreased rib number 3.58801806098721e-08 1.10187591687725e-06 0.977892499240814 0.707865168539326 5.3 5 3 abnormal neuron morphology 6.83834450891085e-09 2.43005456655939e-07 0.976794976794977 0.707070707070707 5.3 5 3 abnormal vision 0.000701680773914805 0.00640525110133239 0.975153304565069 0.705882352941177 5.3 5 3 abnormal nervous system development 0.000701680773914805 0.00640525110133239 0.975153304565069 0.705882352941177 5.3 5 3 abnormal urinary bladder morphology 0.016408601158129 0.0789485403884832 0.975153304565069 0.705882352941177 5.3 5 3 abnormal heart rate 0.016408601158129 0.0789485403884832 0.975153304565069 0.705882352941177 5.3 5 3 increased regulatory T cell number 0.016408601158129 0.0789485403884832 0.975153304565069 0.705882352941177 5.3 5 3 coloboma 0.016408601158129 0.0789485403884832 0.975153304565069 0.705882352941177 5.3 5 3 abnormal ductus venosus valve morphology 0.016408601158129 0.0789485403884832 0.975153304565069 0.705882352941177 5.3 5 3 increased embryonic tissue cell apoptosis 3.21948004844229e-07 7.85142805931393e-06 0.974111474111474 0.705128205128205 5.3 5 3 muscular atrophy 0.000125550905144039 0.00149072972098232 0.973306423306423 0.704545454545455 5.3 5 3 embryonic lethality during organogenesis, incomplete penetrance 2.06981583595037e-18 3.12040417692517e-16 0.973033406076884 0.704347826086957 5.3 5 3 abnormal vitelline vasculature morphology 6.18079323742686e-10 2.67386490053901e-08 0.973033406076884 0.704347826086957 5.3 5 3 abnormal nervous system physiology 6.18079323742686e-10 2.67386490053901e-08 0.973033406076884 0.704347826086957 5.3 5 3 perinatal lethality, complete penetrance 3.80755323615758e-17 4.62014081704487e-15 0.972864212300832 0.704225352112676 5.3 5 3 abnormal trigeminal nerve morphology 0.00269964741569897 0.0195783467829481 0.972143572143572 0.703703703703704 5.3 5 3 increased brain weight 0.00269964741569897 0.0195783467829481 0.972143572143572 0.703703703703704 5.3 5 3 abnormal single cell response 0.00269964741569897 0.0195783467829481 0.972143572143572 0.703703703703704 5.3 5 3 abnormal bone trabecula morphology 0.00269964741569897 0.0195783467829481 0.972143572143572 0.703703703703704 5.3 5 3 decreased body size 4.23130523500992e-60 5.26268588604359e-57 0.971181815542718 0.703007518796993 5.3 5 3 pale liver 7.98475168130363e-07 1.83060551218827e-05 0.970760722112074 0.702702702702703 5.3 5 3 malocclusion 0.000471351758046342 0.00463433793731334 0.970760722112074 0.702702702702703 5.3 5 3 increased circulating phosphate level 0.000471351758046342 0.00463433793731334 0.970760722112074 0.702702702702703 5.3 5 3 abnormal breathing pattern 0.000471351758046342 0.00463433793731334 0.970760722112074 0.702702702702703 5.3 5 3 increased erythroid progenitor cell number 0.000471351758046342 0.00463433793731334 0.970760722112074 0.702702702702703 5.3 5 3 increased trabecular bone volume 0.000471351758046342 0.00463433793731334 0.970760722112074 0.702702702702703 5.3 5 3 cleft palate 5.60547343437854e-11 3.13339666697002e-09 0.970190692328097 0.702290076335878 5.3 5 3 double outlet right ventricle 3.74254302403033e-09 1.37919641070747e-07 0.968318117850828 0.700934579439252 5.3 5 3 increased B cell derived lymphoma incidence 5.74719864648053e-05 0.000760433863463847 0.967027027027027 0.7 5.3 5 3 increased circulating chloride level 5.74719864648053e-05 0.000760433863463847 0.967027027027027 0.7 5.3 5 3 thin ventricular wall 7.05485591458854e-08 2.01712115948724e-06 0.967027027027027 0.7 5.3 5 3 delayed eyelid opening 0.00179623283047276 0.0140507206471729 0.967027027027027 0.7 5.3 5 3 abnormal vascular regression 0.0106838338872542 0.0587965415808513 0.967027027027027 0.7 5.3 5 3 abnormal circulating enzyme level 0.0106838338872542 0.0587965415808513 0.967027027027027 0.7 5.3 5 3 abnormal hearing physiology 0.0106838338872542 0.0587965415808513 0.967027027027027 0.7 5.3 5 3 abnormal sperm mitochondrial sheath morphology 0.0106838338872542 0.0587965415808513 0.967027027027027 0.7 5.3 5 3 absent ductus venosus valve 0.0106838338872542 0.0587965415808513 0.967027027027027 0.7 5.3 5 3 abnormal auchene hair morphology 0.0710532149821615 0.226648503521988 0.967027027027027 0.7 5.3 5 3 small petrosal ganglion 0.0710532149821615 0.226648503521988 0.967027027027027 0.7 5.3 5 3 fused cornea and lens 0.0710532149821615 0.226648503521988 0.967027027027027 0.7 5.3 5 3 abnormal optic nerve innervation 0.0710532149821615 0.226648503521988 0.967027027027027 0.7 5.3 5 3 absent trophoblast giant cells 0.0710532149821615 0.226648503521988 0.967027027027027 0.7 5.3 5 3 rhinitis 0.0710532149821615 0.226648503521988 0.967027027027027 0.7 5.3 5 3 abnormal mammary gland physiology 0.0710532149821615 0.226648503521988 0.967027027027027 0.7 5.3 5 3 abnormal PNS synaptic transmission 0.0710532149821615 0.226648503521988 0.967027027027027 0.7 5.3 5 3 abnormal neuron specification 0.0710532149821615 0.226648503521988 0.967027027027027 0.7 5.3 5 3 abnormal primordial germ cell migration 0.0710532149821615 0.226648503521988 0.967027027027027 0.7 5.3 5 3 primary sex reversal 0.0710532149821615 0.226648503521988 0.967027027027027 0.7 5.3 5 3 impaired basement membrane formation 0.0710532149821615 0.226648503521988 0.967027027027027 0.7 5.3 5 3 bifid ureter 0.0710532149821615 0.226648503521988 0.967027027027027 0.7 5.3 5 3 abnormal pillar cell morphology 0.0710532149821615 0.226648503521988 0.967027027027027 0.7 5.3 5 3 abnormal ear physiology 0.0710532149821615 0.226648503521988 0.967027027027027 0.7 5.3 5 3 abnormal gas homeostasis 0.0710532149821615 0.226648503521988 0.967027027027027 0.7 5.3 5 3 decreased cochlear inner hair cell number 0.0710532149821615 0.226648503521988 0.967027027027027 0.7 5.3 5 3 ascites 0.0710532149821615 0.226648503521988 0.967027027027027 0.7 5.3 5 3 abnormal gonadal fat pad morphology 0.0710532149821615 0.226648503521988 0.967027027027027 0.7 5.3 5 3 increased platelet aggregation 0.0710532149821615 0.226648503521988 0.967027027027027 0.7 5.3 5 3 increased circulating fructosamine level 0.0710532149821615 0.226648503521988 0.967027027027027 0.7 5.3 5 3 abnormal retinal blood vessel pattern 0.0710532149821615 0.226648503521988 0.967027027027027 0.7 5.3 5 3 abnormal vibrissa follicle morphology 0.0710532149821615 0.226648503521988 0.967027027027027 0.7 5.3 5 3 common ventricle 0.0710532149821615 0.226648503521988 0.967027027027027 0.7 5.3 5 3 abnormal left subclavian artery morphology 0.0710532149821615 0.226648503521988 0.967027027027027 0.7 5.3 5 3 abnormal inferior vena cava valve morphology 0.0710532149821615 0.226648503521988 0.967027027027027 0.7 5.3 5 3 thick aortic valve 0.0710532149821615 0.226648503521988 0.967027027027027 0.7 5.3 5 3 fusion of atlas and odontoid process 0.0710532149821615 0.226648503521988 0.967027027027027 0.7 5.3 5 3 increased fatty acid oxidation 0.0710532149821615 0.226648503521988 0.967027027027027 0.7 5.3 5 3 gliosis 7.20509727707138e-06 0.000122339109056076 0.964834221977079 0.698412698412698 5.3 5 3 enlarged kidney 3.89112721801595e-05 0.000542250921838358 0.964420485175202 0.69811320754717 5.3 5 3 abnormal homeostasis 0.000213381888080018 0.0023963315873546 0.963814312651522 0.697674418604651 5.3 5 3 decreased bone mineral content 5.12917973495217e-16 5.67059315141934e-14 0.963042025542025 0.697115384615385 5.3 5 3 abnormal tail morphology 4.89790549727353e-06 8.70252851747707e-05 0.962840762840763 0.696969696969697 5.3 5 3 dilated heart atrium 0.0011979426976768 0.0098835239153268 0.962840762840763 0.696969696969697 5.3 5 3 single kidney 0.0011979426976768 0.0098835239153268 0.962840762840763 0.696969696969697 5.3 5 3 abnormal heart development 1.89833420132279e-12 1.33017079599731e-10 0.961780949122721 0.69620253164557 5.3 5 3 abnormal cranial nerve morphology 0.00700027412835573 0.04195947444406 0.96102064797717 0.695652173913043 5.3 5 3 hypotension 0.00700027412835573 0.04195947444406 0.96102064797717 0.695652173913043 5.3 5 3 abnormal palatal shelf fusion at midline 0.00700027412835573 0.04195947444406 0.96102064797717 0.695652173913043 5.3 5 3 abnormal vertebral artery topology 0.00700027412835573 0.04195947444406 0.96102064797717 0.695652173913043 5.3 5 3 renal hypoplasia 0.00080057556355597 0.00724156987034718 0.959352209352209 0.694444444444444 5.3 5 3 abnormal lysosome morphology 0.00080057556355597 0.00724156987034718 0.959352209352209 0.694444444444444 5.3 5 3 abnormal retinal blood vessel morphology 0.00080057556355597 0.00724156987034718 0.959352209352209 0.694444444444444 5.3 5 3 abnormal embryonic tissue morphology 1.64223274208933e-11 1.0086552952956e-09 0.958569064691514 0.693877551020408 5.3 5 3 abnormal craniofacial development 9.69707901698717e-05 0.0012151881135897 0.958569064691514 0.693877551020408 5.3 5 3 hemorrhage 1.7320508244364e-17 2.20947509014643e-15 0.958209151400641 0.693617021276596 5.3 5 3 small kidney 1.98410590940036e-07 5.22271264511472e-06 0.957607932607933 0.693181818181818 5.3 5 3 neonatal lethality, incomplete penetrance 5.08515467208701e-19 8.43288149787762e-17 0.956400356400356 0.692307692307692 5.3 5 3 abnormal heart ventricle morphology 1.04801999963799e-06 2.28679802552588e-05 0.956400356400356 0.692307692307692 5.3 5 3 abnormal female meiosis 6.5453932505625e-05 0.000852443230930587 0.956400356400356 0.692307692307692 5.3 5 3 abnormal kidney cortex morphology 0.00460972926606514 0.030456046611785 0.956400356400356 0.692307692307692 5.3 5 3 decreased circulating glycerol level 0.00460972926606514 0.030456046611785 0.956400356400356 0.692307692307692 5.3 5 3 absent teeth 0.0444635032606313 0.165945933024487 0.956400356400356 0.692307692307692 5.3 5 3 absent common myeloid progenitor cells 0.0444635032606313 0.165945933024487 0.956400356400356 0.692307692307692 5.3 5 3 short hair 0.0444635032606313 0.165945933024487 0.956400356400356 0.692307692307692 5.3 5 3 lymphoid hypoplasia 0.0444635032606313 0.165945933024487 0.956400356400356 0.692307692307692 5.3 5 3 dystrophic cardiac calcinosis 0.0444635032606313 0.165945933024487 0.956400356400356 0.692307692307692 5.3 5 3 abnormal bile duct development 0.0444635032606313 0.165945933024487 0.956400356400356 0.692307692307692 5.3 5 3 tracheoesophageal fistula 0.0444635032606313 0.165945933024487 0.956400356400356 0.692307692307692 5.3 5 3 abnormal afterhyperpolarization 0.0444635032606313 0.165945933024487 0.956400356400356 0.692307692307692 5.3 5 3 abnormal retinal inner plexiform layer morphology 0.0444635032606313 0.165945933024487 0.956400356400356 0.692307692307692 5.3 5 3 small interparietal bone 0.0444635032606313 0.165945933024487 0.956400356400356 0.692307692307692 5.3 5 3 increased circulating ammonia level 0.0444635032606313 0.165945933024487 0.956400356400356 0.692307692307692 5.3 5 3 hyperalgesia 0.0444635032606313 0.165945933024487 0.956400356400356 0.692307692307692 5.3 5 3 increased circulating thyroxine level 0.0444635032606313 0.165945933024487 0.956400356400356 0.692307692307692 5.3 5 3 orthokeratosis 0.0444635032606313 0.165945933024487 0.956400356400356 0.692307692307692 5.3 5 3 empty decidua capsularis 0.0444635032606313 0.165945933024487 0.956400356400356 0.692307692307692 5.3 5 3 decreased cardiac stroke volume 0.0444635032606313 0.165945933024487 0.956400356400356 0.692307692307692 5.3 5 3 abnormal platelet physiology 4.42143401670527e-05 0.000604303138272217 0.954468234468235 0.690909090909091 5.3 5 3 prenatal lethality, incomplete penetrance 9.26752143460332e-22 2.09572359714325e-19 0.954302987197724 0.690789473684211 5.3 5 3 increased anxiety-related response 9.69346075046078e-11 4.97164610655076e-09 0.954106830365823 0.690647482014389 5.3 5 3 enlarged liver 4.2892618171456e-08 1.29327742668481e-06 0.953212355212355 0.69 5.3 5 3 aphagia 0.00304793443361563 0.0219125344035228 0.952735987218746 0.689655172413793 5.3 5 3 blood in lymph vessels 0.00304793443361563 0.0219125344035228 0.952735987218746 0.689655172413793 5.3 5 3 impaired glucose tolerance 7.22133134833571e-18 1.0566506899403e-15 0.952543903350355 0.689516129032258 5.3 5 3 small placenta 0.000241368847855999 0.00263914289688703 0.951677391677392 0.688888888888889 5.3 5 3 decreased caudal vertebrae number 1.36837167342763e-05 0.000214752336760329 0.949758687258687 0.6875 5.3 5 3 abnormal lumbar vertebrae morphology 0.00202211501724243 0.0155969336601257 0.949758687258687 0.6875 5.3 5 3 failure of tooth eruption 0.0283128201796548 0.120802984900328 0.949758687258687 0.6875 5.3 5 3 abnormal hair follicle orientation 0.0283128201796548 0.120802984900328 0.949758687258687 0.6875 5.3 5 3 delayed hair appearance 0.0283128201796548 0.120802984900328 0.949758687258687 0.6875 5.3 5 3 reduced male mating frequency 0.0283128201796548 0.120802984900328 0.949758687258687 0.6875 5.3 5 3 intraventricular hemorrhage 0.0283128201796548 0.120802984900328 0.949758687258687 0.6875 5.3 5 3 abnormal pulmonary elastic fiber morphology 0.0283128201796548 0.120802984900328 0.949758687258687 0.6875 5.3 5 3 bowed tibia 0.0283128201796548 0.120802984900328 0.949758687258687 0.6875 5.3 5 3 abnormal amnion morphology 0.0283128201796548 0.120802984900328 0.949758687258687 0.6875 5.3 5 3 abnormal coat/hair pigmentation 9.28526667678704e-09 3.16398641897367e-07 0.949758687258687 0.6875 5.3 5 3 small heart 0.00016229751487982 0.00189093708788549 0.949758687258687 0.6875 5.3 5 3 decreased white adipose tissue amount 9.2669006696127e-06 0.000154707486011152 0.948470005186423 0.686567164179104 5.3 5 3 distended abdomen 0.000109255572276629 0.00133117580454667 0.948065712771595 0.686274509803922 5.3 5 3 decreased leukocyte cell number 2.65252837441759e-10 1.26887775603149e-08 0.947867993123468 0.686131386861314 5.3 5 3 increased circulating creatinine level 5.47520832607382e-07 1.27883386958766e-05 0.947750740773997 0.686046511627907 5.3 5 3 abnormal bone mineralization 2.94925081937941e-09 1.11155475957671e-07 0.94761798398162 0.685950413223141 5.3 5 3 increased circulating HDL cholesterol level 3.29918930127827e-08 1.02584167336621e-06 0.947291781577496 0.685714285714286 5.3 5 3 abnormal midbrain development 0.00134538489878742 0.0108130692592366 0.947291781577496 0.685714285714286 5.3 5 3 increased red blood cell distribution width 0.00134538489878742 0.0108130692592366 0.947291781577496 0.685714285714286 5.3 5 3 decreased total body fat amount 6.44971144795826e-23 1.60436572267962e-20 0.947173606455044 0.68562874251497 5.3 5 3 increased insulin sensitivity 1.23753331655315e-10 6.15672824985193e-09 0.946739746739747 0.685314685314685 5.3 5 3 premature death 5.03018882817449e-57 5.00503788403362e-54 0.946649984977511 0.685249709639954 5.3 5 3 short snout 2.2483466451636e-08 7.35889773663745e-07 0.946560846560847 0.685185185185185 5.3 5 3 increased circulating alkaline phosphatase level 7.65001632319749e-12 5.074510827721e-10 0.946560846560846 0.685185185185185 5.3 5 3 decreased hematocrit 8.45318167172103e-11 4.52199772223786e-09 0.946210398265193 0.684931506849315 5.3 5 3 seminiferous tubule degeneration 4.25660579002297e-06 7.72869116984099e-05 0.946210398265193 0.684931506849315 5.3 5 3 postnatal lethality, incomplete penetrance 8.26952573911469e-38 4.57121006134396e-35 0.946110446462559 0.684859154929577 5.3 5 3 abnormal frontal bone morphology 0.000897320942470147 0.00788722913213601 0.94521438731965 0.684210526315789 5.3 5 3 hyporesponsive to tactile stimuli 0.000897320942470147 0.00788722913213601 0.94521438731965 0.684210526315789 5.3 5 3 stereotypic behavior 0.0182445758685587 0.0849081056558276 0.94521438731965 0.684210526315789 5.3 5 3 abnormal neurotransmitter level 0.0182445758685587 0.0849081056558276 0.94521438731965 0.684210526315789 5.3 5 3 abnormal response to novelty 0.0182445758685587 0.0849081056558276 0.94521438731965 0.684210526315789 5.3 5 3 maternal imprinting 0.0182445758685587 0.0849081056558276 0.94521438731965 0.684210526315789 5.3 5 3 increased liver adenoma incidence 0.0182445758685587 0.0849081056558276 0.94521438731965 0.684210526315789 5.3 5 3 abnormal optic vesicle formation 0.0182445758685587 0.0849081056558276 0.94521438731965 0.684210526315789 5.3 5 3 abnormal photoreceptor inner segment morphology 0.0182445758685587 0.0849081056558276 0.94521438731965 0.684210526315789 5.3 5 3 Leydig cell hypoplasia 0.0182445758685587 0.0849081056558276 0.94521438731965 0.684210526315789 5.3 5 3 decreased fertilization frequency 0.0182445758685587 0.0849081056558276 0.94521438731965 0.684210526315789 5.3 5 3 increased liver cholesterol level 0.0182445758685587 0.0849081056558276 0.94521438731965 0.684210526315789 5.3 5 3 decreased circulating magnesium level 0.0182445758685587 0.0849081056558276 0.94521438731965 0.684210526315789 5.3 5 3 shortened RR interval 0.0182445758685587 0.0849081056558276 0.94521438731965 0.684210526315789 5.3 5 3 abnormal placenta morphology 1.95876990581804e-06 3.91360653873284e-05 0.944294022775035 0.683544303797468 5.3 5 3 abnormal kidney development 3.35267303075061e-05 0.00047520080706508 0.944002574002574 0.683333333333333 5.3 5 3 Leydig cell hyperplasia 0.000599743983191454 0.00567196349553183 0.943441001977587 0.682926829268293 5.3 5 3 liver fibrosis 0.000599743983191454 0.00567196349553183 0.943441001977587 0.682926829268293 5.3 5 3 increased bone trabecula number 0.000599743983191454 0.00567196349553183 0.943441001977587 0.682926829268293 5.3 5 3 abnormal hair follicle morphology 2.26516916609903e-05 0.0003394342349802 0.9429061714776 0.682539682539683 5.3 5 3 decreased body length 1.19484077096232e-18 1.85760401110548e-16 0.942826142096215 0.682481751824818 5.3 5 3 insulin resistance 1.05039730836573e-09 4.21429565251574e-08 0.941909441909442 0.681818181818182 5.3 5 3 impaired swimming 1.53151899018552e-05 0.000237361588042772 0.941909441909442 0.681818181818182 5.3 5 3 abnormal abdominal fat pad morphology 0.0118593595610188 0.0611402215710553 0.941909441909442 0.681818181818182 5.3 5 3 increased skin papilloma incidence 0.0118593595610188 0.0611402215710553 0.941909441909442 0.681818181818182 5.3 5 3 abnormal tracheal cartilage morphology 0.0118593595610188 0.0611402215710553 0.941909441909442 0.681818181818182 5.3 5 3 abnormal vascular branching morphogenesis 0.0118593595610188 0.0611402215710553 0.941909441909442 0.681818181818182 5.3 5 3 abnormal basement membrane morphology 0.0118593595610188 0.0611402215710553 0.941909441909442 0.681818181818182 5.3 5 3 abnormal blood-brain barrier function 0.0118593595610188 0.0611402215710553 0.941909441909442 0.681818181818182 5.3 5 3 decreased circulating estradiol level 0.0118593595610188 0.0611402215710553 0.941909441909442 0.681818181818182 5.3 5 3 failure of palatal shelf elevation 0.0118593595610188 0.0611402215710553 0.941909441909442 0.681818181818182 5.3 5 3 pulmonary vascular congestion 0.0118593595610188 0.0611402215710553 0.941909441909442 0.681818181818182 5.3 5 3 increased bone volume 0.0118593595610188 0.0611402215710553 0.941909441909442 0.681818181818182 5.3 5 3 abnormal tibia morphology 0.00026934339448395 0.00291935378552865 0.940573400147868 0.680851063829787 5.3 5 3 increased respiratory quotient 0.00026934339448395 0.00291935378552865 0.940573400147868 0.680851063829787 5.3 5 3 decreased body weight 5.7412513504136e-79 2.85627254683076e-75 0.939576225198196 0.680129240710824 5.3 5 3 decreased heart rate 1.3094306298328e-07 3.59912562619789e-06 0.939397683397683 0.68 5.3 5 3 abnormal interventricular septum morphology 0.000180905748043139 0.00206423416631793 0.939397683397683 0.68 5.3 5 3 decreased oocyte number 0.000180905748043139 0.00206423416631793 0.939397683397683 0.68 5.3 5 3 abnormal thyroid gland morphology 0.00776024283126382 0.045575810148567 0.939397683397683 0.68 5.3 5 3 spontaneous skin ulceration 0.00776024283126382 0.045575810148567 0.939397683397683 0.68 5.3 5 3 abnormal neurocranium morphology 4.75137613568758e-06 8.4724359408766e-05 0.939397683397683 0.68 5.3 5 3 abnormal limb morphology 4.75137613568758e-06 8.4724359408766e-05 0.939397683397683 0.68 5.3 5 3 increased exploration in new environment 2.18328519240276e-06 4.27631646937155e-05 0.938033271366605 0.679012345679012 5.3 5 3 postnatal lethality, complete penetrance 5.44924952468087e-25 1.69437602408046e-22 0.937679796747154 0.678756476683938 5.3 5 3 rib bifurcation 0.00510470401231455 0.0334156611332433 0.93742415885273 0.678571428571429 5.3 5 3 premature aging 0.00510470401231455 0.0334156611332433 0.93742415885273 0.678571428571429 5.3 5 3 enhanced coordination 0.00510470401231455 0.0334156611332433 0.93742415885273 0.678571428571429 5.3 5 3 increased triglyceride level 0.00510470401231455 0.0334156611332433 0.93742415885273 0.678571428571429 5.3 5 3 abnormal mitotic spindle morphology 0.00510470401231455 0.0334156611332433 0.93742415885273 0.678571428571429 5.3 5 3 short limbs 1.00502603456031e-06 2.2123913813883e-05 0.936857054098433 0.67816091954023 5.3 5 3 increased hemoglobin content 5.52085295661085e-05 0.000738339877933844 0.936587919638767 0.677966101694915 5.3 5 3 oxidative stress 6.8228883223297e-07 1.5714754353514e-05 0.936327756327756 0.677777777777778 5.3 5 3 lethargy 4.63356660127665e-07 1.11163336434862e-05 0.935832606800349 0.67741935483871 5.3 5 3 abnormal eyelid morphology 0.00337221577477328 0.024001106551498 0.935832606800349 0.67741935483871 5.3 5 3 decreased thymus weight 0.00337221577477328 0.024001106551498 0.935832606800349 0.67741935483871 5.3 5 3 abnormal podocyte morphology 0.00337221577477328 0.024001106551498 0.935832606800349 0.67741935483871 5.3 5 3 small cranium 0.00337221577477328 0.024001106551498 0.935832606800349 0.67741935483871 5.3 5 3 perinatal lethality, incomplete penetrance 4.68320205778005e-15 4.75488372192974e-13 0.935241056479994 0.676991150442478 5.3 5 3 decreased circulating serum albumin level 2.13913187166393e-07 5.45752874950155e-06 0.934932334932335 0.676767676767677 5.3 5 3 overexpanded pulmonary alveoli 0.00223558126554278 0.0168662008286288 0.934521916874858 0.676470588235294 5.3 5 3 increased circulating free fatty acid level 1.14901519349033e-05 0.000184398406052078 0.933949643808799 0.676056338028169 5.3 5 3 abnormal chromosome morphology 0.00148645849170102 0.0119276306390526 0.933423771261609 0.675675675675676 5.3 5 3 abnormal female reproductive system morphology 0.000990860944575258 0.00849919517114122 0.932490347490347 0.675 5.3 5 3 head bobbing 0.000990860944575258 0.00849919517114122 0.932490347490347 0.675 5.3 5 3 perinatal lethality 0.000990860944575258 0.00849919517114122 0.932490347490347 0.675 5.3 5 3 postnatal lethality 2.83082738658856e-11 1.69679111425037e-09 0.932074242917616 0.674698795180723 5.3 5 3 edema 1.31765556930056e-11 8.19417057158788e-10 0.931687168896471 0.674418604651163 5.3 5 3 kidney failure 0.000661941086898336 0.0060759352533565 0.931687168896471 0.674418604651163 5.3 5 3 decreased oxygen consumption 0.000661941086898336 0.0060759352533565 0.931687168896471 0.674418604651163 5.3 5 3 abnormal muscle physiology 1.11168367628412e-06 2.3942105149409e-05 0.931326189753156 0.674157303370786 5.3 5 3 abnormal rib morphology 2.11340821309676e-09 8.21422332824718e-08 0.931211211211211 0.674074074074074 5.3 5 3 abnormal spermatogenesis 2.85667823397753e-12 1.97388530750531e-10 0.930988752727883 0.673913043478261 5.3 5 3 abnormal myelin sheath morphology 0.000443047750134465 0.00440832511383793 0.930988752727883 0.673913043478261 5.3 5 3 decreased hemoglobin content 9.81359167371139e-10 4.00185398169788e-08 0.930775760562995 0.673758865248227 5.3 5 3 abnormal long bone hypertrophic chondrocyte zone 0.000297033884594086 0.00318479218934391 0.930375856906469 0.673469387755102 5.3 5 3 increased sarcoma incidence 0.000297033884594086 0.00318479218934391 0.930375856906469 0.673469387755102 5.3 5 3 eyelids open at birth 0.00019943541886399 0.00226011664885728 0.92983367983368 0.673076923076923 5.3 5 3 kinked neural tube 0.00019943541886399 0.00226011664885728 0.92983367983368 0.673076923076923 5.3 5 3 abnormal long bone morphology 6.08114537721104e-05 0.000798250613499338 0.928527121969745 0.672131147540984 5.3 5 3 increased osteoclast cell number 6.08114537721104e-05 0.000798250613499338 0.928527121969745 0.672131147540984 5.3 5 3 abnormal seminiferous tubule morphology 7.36883955556099e-10 3.13333134947999e-08 0.927286190299889 0.671232876712329 5.3 5 3 decreased percent body fat/body weight 1.26455277625056e-05 0.00020099520964366 0.927286190299889 0.671232876712329 5.3 5 3 abnormal axial skeleton morphology 8.55491223115167e-06 0.000143786109290472 0.927037187563503 0.671052631578947 5.3 5 3 abnormal placenta labyrinth morphology 5.79107633476226e-06 0.000101804257121704 0.92680709642735 0.670886075949367 5.3 5 3 cardiac fibrosis 2.65803809077466e-06 5.04722881740608e-05 0.926395639336816 0.670588235294118 5.3 5 3 abnormal suckling behavior 1.80212105393943e-06 3.65940907891782e-05 0.926210951210951 0.670454545454545 5.3 5 3 thrombocytopenia 1.187147090975e-09 4.72484542208049e-08 0.924153907602184 0.668965517241379 5.3 5 3 increased or absent threshold for auditory brainstem response 1.27360792668873e-17 1.71248633385849e-15 0.922571508730678 0.667820069204152 5.3 5 3 cyanosis 4.16123941260391e-12 2.7975900105006e-10 0.920978120978121 0.666666666666667 5.3 5 3 decreased circulating cholesterol level 1.31069500092352e-11 8.19417057158788e-10 0.920978120978121 0.666666666666667 5.3 5 3 decreased insulin secretion 1.9704733643864e-06 3.92124199512894e-05 0.920978120978121 0.666666666666667 5.3 5 3 absent gastric milk in neonates 9.35118830576066e-06 0.000155592514452038 0.920978120978121 0.666666666666667 5.3 5 3 delayed bone ossification 1.38211819331769e-05 0.000215693451052587 0.920978120978121 0.666666666666667 5.3 5 3 increased circulating aspartate transaminase level 6.64304297435508e-05 0.000862901796277193 0.920978120978121 0.666666666666667 5.3 5 3 abnormal incisor morphology 9.85721280833148e-05 0.0012198913861057 0.920978120978121 0.666666666666667 5.3 5 3 muscular ventricular septal defect 9.85721280833148e-05 0.0012198913861057 0.920978120978121 0.666666666666667 5.3 5 3 decreased tumor growth/size 0.000217734855765788 0.00243422675828043 0.920978120978121 0.666666666666667 5.3 5 3 abnormal cervical vertebrae morphology 0.000324206099576162 0.00340279608732365 0.920978120978121 0.666666666666667 5.3 5 3 abnormal pancreas morphology 0.00108038311371867 0.00904866328409158 0.920978120978121 0.666666666666667 5.3 5 3 dextrocardia 0.0036704596563737 0.0253971304457012 0.920978120978121 0.666666666666667 5.3 5 3 decreased brown adipose tissue amount 0.0036704596563737 0.0253971304457012 0.920978120978121 0.666666666666667 5.3 5 3 head tossing 0.0036704596563737 0.0253971304457012 0.920978120978121 0.666666666666667 5.3 5 3 cardiovascular system phenotype 0.0036704596563737 0.0253971304457012 0.920978120978121 0.666666666666667 5.3 5 3 thin epidermis 0.00842989296679746 0.0489366598714322 0.920978120978121 0.666666666666667 5.3 5 3 abnormal skin appearance 0.00842989296679746 0.0489366598714322 0.920978120978121 0.666666666666667 5.3 5 3 thick interventricular septum 0.00842989296679746 0.0489366598714322 0.920978120978121 0.666666666666667 5.3 5 3 decreased bone ossification 0.00842989296679746 0.0489366598714322 0.920978120978121 0.666666666666667 5.3 5 3 abnormal adrenal gland morphology 0.0128641500879745 0.0653798545587955 0.920978120978121 0.666666666666667 5.3 5 3 abnormal body weight 0.0128641500879745 0.0653798545587955 0.920978120978121 0.666666666666667 5.3 5 3 decreased metastatic potential 0.0128641500879745 0.0653798545587955 0.920978120978121 0.666666666666667 5.3 5 3 abnormal vasodilation 0.0128641500879745 0.0653798545587955 0.920978120978121 0.666666666666667 5.3 5 3 blindness 0.0128641500879745 0.0653798545587955 0.920978120978121 0.666666666666667 5.3 5 3 small ears 0.0197518309106081 0.0915800175025863 0.920978120978121 0.666666666666667 5.3 5 3 complete atrioventricular septal defect 0.0197518309106081 0.0915800175025863 0.920978120978121 0.666666666666667 5.3 5 3 vascular ring 0.0197518309106081 0.0915800175025863 0.920978120978121 0.666666666666667 5.3 5 3 lowered ear position 0.0305677183040024 0.126027114565209 0.920978120978121 0.666666666666667 5.3 5 3 abnormal megakaryocyte differentiation 0.0305677183040024 0.126027114565209 0.920978120978121 0.666666666666667 5.3 5 3 cortical renal glomerulopathies 0.0305677183040024 0.126027114565209 0.920978120978121 0.666666666666667 5.3 5 3 delayed kidney development 0.0305677183040024 0.126027114565209 0.920978120978121 0.666666666666667 5.3 5 3 abnormal radius morphology 0.0305677183040024 0.126027114565209 0.920978120978121 0.666666666666667 5.3 5 3 abnormal phrenic nerve morphology 0.0305677183040024 0.126027114565209 0.920978120978121 0.666666666666667 5.3 5 3 abnormal metacarpal bone morphology 0.0305677183040024 0.126027114565209 0.920978120978121 0.666666666666667 5.3 5 3 increased circulating renin level 0.0305677183040024 0.126027114565209 0.920978120978121 0.666666666666667 5.3 5 3 increased circulating glycerol level 0.0305677183040024 0.126027114565209 0.920978120978121 0.666666666666667 5.3 5 3 abnormal neutrophil morphology 0.0305677183040024 0.126027114565209 0.920978120978121 0.666666666666667 5.3 5 3 decreased pulmonary respiratory rate 0.0305677183040024 0.126027114565209 0.920978120978121 0.666666666666667 5.3 5 3 decreased tumor latency 0.0305677183040024 0.126027114565209 0.920978120978121 0.666666666666667 5.3 5 3 primary atelectasis 0.0305677183040024 0.126027114565209 0.920978120978121 0.666666666666667 5.3 5 3 macrocytosis 0.0478075990890371 0.176179855902192 0.920978120978121 0.666666666666667 5.3 5 3 interdigital webbing 0.0478075990890371 0.176179855902192 0.920978120978121 0.666666666666667 5.3 5 3 decreased hepatocyte number 0.0478075990890371 0.176179855902192 0.920978120978121 0.666666666666667 5.3 5 3 abnormal prostate gland morphology 0.0478075990890371 0.176179855902192 0.920978120978121 0.666666666666667 5.3 5 3 no suckling reflex 0.0478075990890371 0.176179855902192 0.920978120978121 0.666666666666667 5.3 5 3 absent egg cylinders 0.0478075990890371 0.176179855902192 0.920978120978121 0.666666666666667 5.3 5 3 abnormal cricoid cartilage morphology 0.0478075990890371 0.176179855902192 0.920978120978121 0.666666666666667 5.3 5 3 altered righting response 0.0478075990890371 0.176179855902192 0.920978120978121 0.666666666666667 5.3 5 3 dilated ureter 0.0478075990890371 0.176179855902192 0.920978120978121 0.666666666666667 5.3 5 3 abnormal pericyte morphology 0.0478075990890371 0.176179855902192 0.920978120978121 0.666666666666667 5.3 5 3 abnormal olfactory nerve morphology 0.0478075990890371 0.176179855902192 0.920978120978121 0.666666666666667 5.3 5 3 abnormal energy homeostasis 0.0478075990890371 0.176179855902192 0.920978120978121 0.666666666666667 5.3 5 3 abnormal dendritic cell morphology 0.0478075990890371 0.176179855902192 0.920978120978121 0.666666666666667 5.3 5 3 abnormal cerebral aqueduct morphology 0.0478075990890371 0.176179855902192 0.920978120978121 0.666666666666667 5.3 5 3 decreased trabecular bone mass 0.0478075990890371 0.176179855902192 0.920978120978121 0.666666666666667 5.3 5 3 abnormal mineral level 0.0758868486133987 0.229505818754808 0.920978120978121 0.666666666666667 5.3 5 3 abnormal enteric nervous system morphology 0.0758868486133987 0.229505818754808 0.920978120978121 0.666666666666667 5.3 5 3 impaired embryo implantation 0.0758868486133987 0.229505818754808 0.920978120978121 0.666666666666667 5.3 5 3 increased papilloma incidence 0.0758868486133987 0.229505818754808 0.920978120978121 0.666666666666667 5.3 5 3 abnormal embryonic growth/weight/body size 0.0758868486133987 0.229505818754808 0.920978120978121 0.666666666666667 5.3 5 3 altered tumor susceptibility 0.0758868486133987 0.229505818754808 0.920978120978121 0.666666666666667 5.3 5 3 abnormal tracheal ciliated epithelium morphology 0.0758868486133987 0.229505818754808 0.920978120978121 0.666666666666667 5.3 5 3 small intestinal inflammation 0.0758868486133987 0.229505818754808 0.920978120978121 0.666666666666667 5.3 5 3 decreased left ventricle systolic pressure 0.0758868486133987 0.229505818754808 0.920978120978121 0.666666666666667 5.3 5 3 abnormal rostral-caudal body axis extension 0.0758868486133987 0.229505818754808 0.920978120978121 0.666666666666667 5.3 5 3 increased hepatocyte proliferation 0.0758868486133987 0.229505818754808 0.920978120978121 0.666666666666667 5.3 5 3 bowed ulna 0.0758868486133987 0.229505818754808 0.920978120978121 0.666666666666667 5.3 5 3 absent cochlear hair cells 0.0758868486133987 0.229505818754808 0.920978120978121 0.666666666666667 5.3 5 3 decreased cochlear nerve compound action potential 0.0758868486133987 0.229505818754808 0.920978120978121 0.666666666666667 5.3 5 3 hematuria 0.0758868486133987 0.229505818754808 0.920978120978121 0.666666666666667 5.3 5 3 abnormal behavioral response to addictive substance 0.0758868486133987 0.229505818754808 0.920978120978121 0.666666666666667 5.3 5 3 persistent right dorsal aorta 0.0758868486133987 0.229505818754808 0.920978120978121 0.666666666666667 5.3 5 3 embryonic lethality between implantation and placentation, incomplete penetrance 0.0758868486133987 0.229505818754808 0.920978120978121 0.666666666666667 5.3 5 3 thick tail 0.123194522224633 0.325384603867126 0.920978120978121 0.666666666666667 5.3 5 3 abnormal cholinergic neuron morphology 0.123194522224633 0.325384603867126 0.920978120978121 0.666666666666667 5.3 5 3 small nodose ganglion 0.123194522224633 0.325384603867126 0.920978120978121 0.666666666666667 5.3 5 3 abnormal kindling response 0.123194522224633 0.325384603867126 0.920978120978121 0.666666666666667 5.3 5 3 increased pheochromocytoma incidence 0.123194522224633 0.325384603867126 0.920978120978121 0.666666666666667 5.3 5 3 abnormal germ cell morphology 0.123194522224633 0.325384603867126 0.920978120978121 0.666666666666667 5.3 5 3 abnormal laryngeal cartilage morphology 0.123194522224633 0.325384603867126 0.920978120978121 0.666666666666667 5.3 5 3 abnormal abdominal wall morphology 0.123194522224633 0.325384603867126 0.920978120978121 0.666666666666667 5.3 5 3 premature bone ossification 0.123194522224633 0.325384603867126 0.920978120978121 0.666666666666667 5.3 5 3 short frontal bone 0.123194522224633 0.325384603867126 0.920978120978121 0.666666666666667 5.3 5 3 decreased cochlear hair cell number 0.123194522224633 0.325384603867126 0.920978120978121 0.666666666666667 5.3 5 3 abnormal gallbladder physiology 0.123194522224633 0.325384603867126 0.920978120978121 0.666666666666667 5.3 5 3 hemothorax 0.123194522224633 0.325384603867126 0.920978120978121 0.666666666666667 5.3 5 3 absent adrenal gland 0.123194522224633 0.325384603867126 0.920978120978121 0.666666666666667 5.3 5 3 decreased susceptibility to atherosclerosis 0.123194522224633 0.325384603867126 0.920978120978121 0.666666666666667 5.3 5 3 abnormal optic chiasm morphology 0.123194522224633 0.325384603867126 0.920978120978121 0.666666666666667 5.3 5 3 shortened ST segment 0.123194522224633 0.325384603867126 0.920978120978121 0.666666666666667 5.3 5 3 abnormal pulmonary alveolar parenchyma morphology 0.123194522224633 0.325384603867126 0.920978120978121 0.666666666666667 5.3 5 3 abnormal oxidative phosphorylation 0.123194522224633 0.325384603867126 0.920978120978121 0.666666666666667 5.3 5 3 decreased pancreatic beta cell proliferation 0.123194522224633 0.325384603867126 0.920978120978121 0.666666666666667 5.3 5 3 trigeminal neuroma 0.123194522224633 0.325384603867126 0.920978120978121 0.666666666666667 5.3 5 3 abnormal ductus venosus valve topology 0.123194522224633 0.325384603867126 0.920978120978121 0.666666666666667 5.3 5 3 abnormal infrahyoid muscle connection 0.123194522224633 0.325384603867126 0.920978120978121 0.666666666666667 5.3 5 3 symmetric azygos veins 0.123194522224633 0.325384603867126 0.920978120978121 0.666666666666667 5.3 5 3 increased cardiac muscle glycogen level 0.123194522224633 0.325384603867126 0.920978120978121 0.666666666666667 5.3 5 3 postnatal growth retardation 5.5503066730566e-35 2.30106464153805e-32 0.918720821661998 0.665032679738562 5.3 5 3 increased total body fat amount 9.65495967059674e-09 3.26757988851828e-07 0.917541635452083 0.664179104477612 5.3 5 3 increased sensitivity to xenobiotic induced morbidity/mortality 2.1020188594435e-07 5.4321813898884e-06 0.916791856791857 0.663636363636364 5.3 5 3 abnormal kidney morphology 7.18958089871039e-11 3.93056757924002e-09 0.915715388858246 0.662857142857143 5.3 5 3 abnormal lipid level 6.87985875840105e-06 0.000117619578429709 0.915430060008373 0.662650602409639 5.3 5 3 decreased erythrocyte cell number 7.15236521701287e-10 3.06750146160681e-08 0.915112018296732 0.662420382165605 5.3 5 3 small seminiferous tubules 2.21924584967094e-05 0.000334568124306452 0.914755295836377 0.662162162162162 5.3 5 3 abnormal embryo development 1.04866016229225e-08 3.52505696446211e-07 0.914206223029753 0.661764705882353 5.3 5 3 abnormal neuron differentiation 2.27916678850159e-07 5.74390330615561e-06 0.912755102040816 0.660714285714286 5.3 5 3 abnormal mesoderm development 0.000350661668449413 0.00364966903877789 0.912289648138705 0.660377358490566 5.3 5 3 decreased circulating alkaline phosphatase level 0.000522459090840041 0.00504705626588195 0.91176833976834 0.66 5.3 5 3 decreased respiratory quotient 0.000522459090840041 0.00504705626588195 0.91176833976834 0.66 5.3 5 3 abnormal developmental patterning 1.09752586882983e-05 0.000178437620830994 0.909746680478388 0.658536585365854 5.3 5 3 hunched posture 1.62077002499058e-05 0.000249638726759384 0.909320170079664 0.658227848101266 5.3 5 3 decreased bone volume 0.00394179096849056 0.0270488414734352 0.907821290678434 0.657142857142857 5.3 5 3 abnormal cranium morphology 2.63864734451674e-08 8.36131881463108e-07 0.90723217887397 0.656716417910448 5.3 5 3 abnormal vertebral body morphology 0.0059496808573322 0.0367697667891027 0.906587837837838 0.65625 5.3 5 3 failure of primitive streak formation 0.0059496808573322 0.0367697667891027 0.906587837837838 0.65625 5.3 5 3 increased circulating follicle stimulating hormone level 0.0059496808573322 0.0367697667891027 0.906587837837838 0.65625 5.3 5 3 neonatal lethality 0.0059496808573322 0.0367697667891027 0.906587837837838 0.65625 5.3 5 3 abnormal heart atrium morphology 0.0059496808573322 0.0367697667891027 0.906587837837838 0.65625 5.3 5 3 abnormal embryonic hematopoiesis 0.0059496808573322 0.0367697667891027 0.906587837837838 0.65625 5.3 5 3 bradykinesia 0.0059496808573322 0.0367697667891027 0.906587837837838 0.65625 5.3 5 3 dermatitis 0.000253134123962069 0.00275567235604221 0.905099187857809 0.655172413793103 5.3 5 3 abnormal enzyme/coenzyme level 0.000253134123962069 0.00275567235604221 0.905099187857809 0.655172413793103 5.3 5 3 abnormal parietal bone morphology 0.00901256621184252 0.0514191707613721 0.905099187857809 0.655172413793103 5.3 5 3 abnormal spinal nerve morphology 0.00901256621184252 0.0514191707613721 0.905099187857809 0.655172413793103 5.3 5 3 decreased trophoblast giant cell number 0.00901256621184252 0.0514191707613721 0.905099187857809 0.655172413793103 5.3 5 3 abnormal embryonic erythropoiesis 0.00901256621184252 0.0514191707613721 0.905099187857809 0.655172413793103 5.3 5 3 polychromatophilia 0.00901256621184252 0.0514191707613721 0.905099187857809 0.655172413793103 5.3 5 3 decreased heart weight 1.74064087686331e-05 0.000266451949612153 0.903922970589637 0.654320987654321 5.3 5 3 decreased cardiac muscle contractility 1.23751442185941e-06 2.61984436117045e-05 0.903267003267003 0.653846153846154 5.3 5 3 abnormal Schwann cell morphology 0.0137112128988613 0.0684185397912087 0.903267003267003 0.653846153846154 5.3 5 3 no spontaneous movement 0.0137112128988613 0.0684185397912087 0.903267003267003 0.653846153846154 5.3 5 3 abnormal erythrocyte osmotic lysis 0.0137112128988613 0.0684185397912087 0.903267003267003 0.653846153846154 5.3 5 3 abnormal pulmonary alveolus morphology 1.82071141890195e-06 3.67912944506687e-05 0.902740930463703 0.653465346534653 5.3 5 3 respiratory distress 4.85655731951485e-10 2.17670024005283e-08 0.902345615640413 0.653179190751445 5.3 5 3 abnormal neuromuscular synapse morphology 5.61285849467278e-05 0.000746630240935751 0.901791076791077 0.652777777777778 5.3 5 3 abnormal digit morphology 5.61285849467278e-05 0.000746630240935751 0.901791076791077 0.652777777777778 5.3 5 3 abnormal carpal bone morphology 0.020970144747262 0.0965985834422485 0.900956857478597 0.652173913043478 5.3 5 3 abnormal innervation pattern to muscle 0.020970144747262 0.0965985834422485 0.900956857478597 0.652173913043478 5.3 5 3 blistering 0.020970144747262 0.0965985834422485 0.900956857478597 0.652173913043478 5.3 5 3 dilated heart 0.020970144747262 0.0965985834422485 0.900956857478597 0.652173913043478 5.3 5 3 abnormal corneal stroma morphology 0.020970144747262 0.0965985834422485 0.900956857478597 0.652173913043478 5.3 5 3 microcephaly 8.30291378198654e-05 0.00104574673583248 0.900956857478597 0.652173913043478 5.3 5 3 abnormal liver physiology 2.86228241144396e-06 5.39388446853549e-05 0.897953667953668 0.65 5.3 5 3 increased erythrocyte cell number 0.000270025836425814 0.00292038812221397 0.897953667953668 0.65 5.3 5 3 small gonad 0.0322859538338387 0.130375503509211 0.897953667953668 0.65 5.3 5 3 anencephaly 0.0322859538338387 0.130375503509211 0.897953667953668 0.65 5.3 5 3 kidney atrophy 0.0322859538338387 0.130375503509211 0.897953667953668 0.65 5.3 5 3 hypoactivity 1.31623347963372e-19 2.42528205969546e-17 0.897770449494588 0.649867374005305 5.3 5 3 cleft secondary palate 6.19642139079705e-06 0.000108165601470931 0.896484022015937 0.648936170212766 5.3 5 3 abnormal angiogenesis 5.98087963798558e-05 0.000789254010582978 0.896086820411145 0.648648648648649 5.3 5 3 abnormal humerus morphology 0.00418616371241832 0.0284122298353085 0.896086820411145 0.648648648648649 5.3 5 3 decreased circulating HDL cholesterol level 1.50164578441842e-07 4.10477350411079e-06 0.895795125482626 0.6484375 5.3 5 3 abnormal blood vessel morphology 2.36281938972127e-08 7.6331340674437e-07 0.895571827985621 0.648275862068965 5.3 5 3 increased blood urea nitrogen level 2.36281938972127e-08 7.6331340674437e-07 0.895571827985621 0.648275862068965 5.3 5 3 abnormal long bone epiphyseal plate proliferative zone 0.000595526849708729 0.00566490645755435 0.895395395395395 0.648148148148148 5.3 5 3 abnormal osteoblast physiology 0.000595526849708729 0.00566490645755435 0.895395395395395 0.648148148148148 5.3 5 3 hyperglycemia 1.34319146417556e-05 0.000211467643489665 0.89481396981397 0.647727272727273 5.3 5 3 small lung 0.000885922908157156 0.00785644646716908 0.893890529184647 0.647058823529412 5.3 5 3 failure of chorioallantoic fusion 0.000885922908157156 0.00785644646716908 0.893890529184647 0.647058823529412 5.3 5 3 lung hemorrhage 0.00630107003956371 0.0382290529839384 0.893890529184647 0.647058823529412 5.3 5 3 abnormal endoderm development 0.00630107003956371 0.0382290529839384 0.893890529184647 0.647058823529412 5.3 5 3 abnormal brown adipose tissue morphology 0.00630107003956371 0.0382290529839384 0.893890529184647 0.647058823529412 5.3 5 3 increased susceptibility to weight gain 0.00630107003956371 0.0382290529839384 0.893890529184647 0.647058823529412 5.3 5 3 enlarged sebaceous gland 0.0501372217191189 0.180766447133286 0.893890529184647 0.647058823529412 5.3 5 3 abnormal vagus nerve morphology 0.0501372217191189 0.180766447133286 0.893890529184647 0.647058823529412 5.3 5 3 increased aggression towards mice 0.0501372217191189 0.180766447133286 0.893890529184647 0.647058823529412 5.3 5 3 abnormal cranial suture morphology 0.0501372217191189 0.180766447133286 0.893890529184647 0.647058823529412 5.3 5 3 aminoaciduria 0.0501372217191189 0.180766447133286 0.893890529184647 0.647058823529412 5.3 5 3 abnormal embryonic-extraembryonic boundary morphology 0.0501372217191189 0.180766447133286 0.893890529184647 0.647058823529412 5.3 5 3 abnormal ectoplacental cone morphology 0.0501372217191189 0.180766447133286 0.893890529184647 0.647058823529412 5.3 5 3 decreased growth hormone level 0.0501372217191189 0.180766447133286 0.893890529184647 0.647058823529412 5.3 5 3 abnormal electroretinogram waveform feature 0.0501372217191189 0.180766447133286 0.893890529184647 0.647058823529412 5.3 5 3 decreased bone mineral density 6.47568859949026e-14 5.75295549686857e-12 0.893279530873516 0.646616541353383 5.3 5 3 increased bone mineral density 1.02072197610677e-06 2.23704485952915e-05 0.892452249974374 0.646017699115044 5.3 5 3 oligodactyly 0.00131966513632316 0.0106407359047127 0.892197554697555 0.645833333333333 5.3 5 3 abnormal phalanx morphology 0.00131966513632316 0.0106407359047127 0.892197554697555 0.645833333333333 5.3 5 3 abnormal visceral yolk sac morphology 4.29916271742124e-05 0.000589210317332525 0.891833243731978 0.645569620253165 5.3 5 3 prenatal lethality 0.000286268677151339 0.00308265512733314 0.891269149333665 0.645161290322581 5.3 5 3 osteopetrosis 0.00951337739467974 0.0534791554107703 0.891269149333665 0.645161290322581 5.3 5 3 abnormal mitochondrial ATP synthesis coupled electron transport 0.00951337739467974 0.0534791554107703 0.891269149333665 0.645161290322581 5.3 5 3 thymus hypoplasia 7.89131531732889e-08 2.23064168771087e-06 0.890946225728834 0.644927536231884 5.3 5 3 irregular heartbeat 0.00196867242302886 0.0152083001623736 0.89027885027885 0.644444444444444 5.3 5 3 abnormal ectoderm development 0.00196867242302886 0.0152083001623736 0.89027885027885 0.644444444444444 5.3 5 3 increased circulating corticosterone level 0.00196867242302886 0.0152083001623736 0.89027885027885 0.644444444444444 5.3 5 3 abnormal myocardial trabeculae morphology 0.00196867242302886 0.0152083001623736 0.89027885027885 0.644444444444444 5.3 5 3 increased circulating insulin level 9.01788518820205e-09 3.11555408411842e-07 0.889319498069498 0.64375 5.3 5 3 abnormal skeleton morphology 1.08142301673465e-06 2.3493796979279e-05 0.888944099378882 0.643478260869565 5.3 5 3 increased body weight 1.30258548846965e-11 8.19417057158788e-10 0.888086045228902 0.642857142857143 5.3 5 3 arrest of spermatogenesis 3.08520839794837e-05 0.000444895993617192 0.888086045228902 0.642857142857143 5.3 5 3 abnormal ovulation 0.0144152330848667 0.0708653997996164 0.888086045228902 0.642857142857143 5.3 5 3 abnormal brainstem morphology 0.0144152330848667 0.0708653997996164 0.888086045228902 0.642857142857143 5.3 5 3 abnormal interparietal bone morphology 0.0787642562979084 0.234782609396102 0.888086045228902 0.642857142857143 5.3 5 3 abnormal blood flow velocity 0.0787642562979084 0.234782609396102 0.888086045228902 0.642857142857143 5.3 5 3 absent atrioventricular cushions 0.0787642562979084 0.234782609396102 0.888086045228902 0.642857142857143 5.3 5 3 megacephaly 0.0787642562979084 0.234782609396102 0.888086045228902 0.642857142857143 5.3 5 3 increased aggression towards males 0.0787642562979084 0.234782609396102 0.888086045228902 0.642857142857143 5.3 5 3 extended life span 0.0787642562979084 0.234782609396102 0.888086045228902 0.642857142857143 5.3 5 3 abnormal endplate potential 0.0787642562979084 0.234782609396102 0.888086045228902 0.642857142857143 5.3 5 3 decreased vascular permeability 0.0787642562979084 0.234782609396102 0.888086045228902 0.642857142857143 5.3 5 3 intestinal obstruction 0.0787642562979084 0.234782609396102 0.888086045228902 0.642857142857143 5.3 5 3 abnormal ventral body wall morphology 0.0787642562979084 0.234782609396102 0.888086045228902 0.642857142857143 5.3 5 3 abnormal uterus development 0.0787642562979084 0.234782609396102 0.888086045228902 0.642857142857143 5.3 5 3 abnormal decidualization 0.0787642562979084 0.234782609396102 0.888086045228902 0.642857142857143 5.3 5 3 abnormal maternal decidual layer morphology 0.0787642562979084 0.234782609396102 0.888086045228902 0.642857142857143 5.3 5 3 split sternum 0.0787642562979084 0.234782609396102 0.888086045228902 0.642857142857143 5.3 5 3 abnormal glucose tolerance 0.0787642562979084 0.234782609396102 0.888086045228902 0.642857142857143 5.3 5 3 sternebra fusion 0.0787642562979084 0.234782609396102 0.888086045228902 0.642857142857143 5.3 5 3 increased stomach tumor incidence 0.0787642562979084 0.234782609396102 0.888086045228902 0.642857142857143 5.3 5 3 decreased compact bone area 0.0787642562979084 0.234782609396102 0.888086045228902 0.642857142857143 5.3 5 3 abnormal vitelline vein topology 0.0787642562979084 0.234782609396102 0.888086045228902 0.642857142857143 5.3 5 3 decreased birth weight 1.02359783955896e-05 0.000166963909895273 0.88704734809998 0.642105263157895 5.3 5 3 abnormal skeleton development 4.54324119828084e-05 0.000619249998943758 0.886867820201153 0.641975308641975 5.3 5 3 increased circulating triglyceride level 6.03458870750532e-08 1.75567712396719e-06 0.886044468113434 0.641379310344828 5.3 5 3 increased circulating alanine transaminase level 6.69284549460408e-05 0.000867106935824356 0.885555885555886 0.641025641025641 5.3 5 3 acanthosis 0.00440411295736076 0.029252953221455 0.885555885555886 0.641025641025641 5.3 5 3 increased hepatocyte apoptosis 0.00440411295736076 0.029252953221455 0.885555885555886 0.641025641025641 5.3 5 3 abnormal osteoclast physiology 0.000301799244183616 0.00321509901458992 0.885002413127413 0.640625 5.3 5 3 abnormal primitive streak morphology 0.0219377629887934 0.0995806303551524 0.884138996138996 0.64 5.3 5 3 decreased placenta weight 0.0219377629887934 0.0995806303551524 0.884138996138996 0.64 5.3 5 3 abnormal energy expenditure 0.0219377629887934 0.0995806303551524 0.884138996138996 0.64 5.3 5 3 impaired conditioned place preference behavior 0.0219377629887934 0.0995806303551524 0.884138996138996 0.64 5.3 5 3 abnormal preimplantation embryo development 0.0219377629887934 0.0995806303551524 0.884138996138996 0.64 5.3 5 3 abnormal uterus morphology 0.00660764559791551 0.0398944621961525 0.882604032604033 0.638888888888889 5.3 5 3 abnormal limb bone morphology 0.00660764559791551 0.0398944621961525 0.882604032604033 0.638888888888889 5.3 5 3 short radius 0.00660764559791551 0.0398944621961525 0.882604032604033 0.638888888888889 5.3 5 3 abnormal lung morphology 1.20309338434382e-06 2.56883673266546e-05 0.882281561273158 0.638655462184874 5.3 5 3 short tail 4.78136182830038e-05 0.000644641601512043 0.882141694189887 0.63855421686747 5.3 5 3 neonatal lethality, complete penetrance 2.99958223606884e-21 6.21788401018436e-19 0.881594188173136 0.638157894736842 5.3 5 3 abnormal retina morphology 1.39936735205695e-10 6.89292334305282e-09 0.881507630079059 0.638095238095238 5.3 5 3 abnormal spermiogenesis 0.000660956902808546 0.0060759352533565 0.88128078817734 0.637931034482759 5.3 5 3 cochlear ganglion degeneration 0.000660956902808546 0.0060759352533565 0.88128078817734 0.637931034482759 5.3 5 3 thrombocytosis 0.000660956902808546 0.0060759352533565 0.88128078817734 0.637931034482759 5.3 5 3 perimembraneous ventricular septal defect 0.000214508771736431 0.00240356112474942 0.880935593979072 0.63768115942029 5.3 5 3 abnormal glucose homeostasis 2.5877686759193e-09 9.97996059123917e-08 0.880495566209852 0.637362637362637 5.3 5 3 increased spleen weight 2.57873386996745e-06 4.9154026831755e-05 0.880226876687054 0.63716814159292 5.3 5 3 increased circulating calcium level 0.000979286328646041 0.00844358662914047 0.879115479115479 0.636363636363636 5.3 5 3 obese 0.000103511795177547 0.00127784412160868 0.879115479115479 0.636363636363636 5.3 5 3 abnormal skeleton physiology 0.00993831795900952 0.0556165712554245 0.879115479115479 0.636363636363636 5.3 5 3 increased osteoblast cell number 0.00993831795900952 0.0556165712554245 0.879115479115479 0.636363636363636 5.3 5 3 increased circulating cholesterol level 5.50418616397359e-09 1.98429899751946e-07 0.879115479115479 0.636363636363636 5.3 5 3 renal interstitial fibrosis 0.00307980840194922 0.022109735641699 0.879115479115479 0.636363636363636 5.3 5 3 abnormal long bone epiphysis morphology 0.0335636557723895 0.131004846743247 0.879115479115479 0.636363636363636 5.3 5 3 abnormal enterocyte morphology 0.0335636557723895 0.131004846743247 0.879115479115479 0.636363636363636 5.3 5 3 abnormal germ layer development 0.0335636557723895 0.131004846743247 0.879115479115479 0.636363636363636 5.3 5 3 testis hypoplasia 0.0335636557723895 0.131004846743247 0.879115479115479 0.636363636363636 5.3 5 3 abnormal chorion morphology 0.0335636557723895 0.131004846743247 0.879115479115479 0.636363636363636 5.3 5 3 abnormal cochlear sensory epithelium morphology 0.0335636557723895 0.131004846743247 0.879115479115479 0.636363636363636 5.3 5 3 abnormal female reproductive system physiology 0.0335636557723895 0.131004846743247 0.879115479115479 0.636363636363636 5.3 5 3 cleft upper lip 0.0335636557723895 0.131004846743247 0.879115479115479 0.636363636363636 5.3 5 3 abnormal temporal bone morphology 0.0335636557723895 0.131004846743247 0.879115479115479 0.636363636363636 5.3 5 3 increased circulating creatine kinase level 0.0335636557723895 0.131004846743247 0.879115479115479 0.636363636363636 5.3 5 3 abnormal sebaceous gland morphology 0.125782830614759 0.325384603867126 0.879115479115479 0.636363636363636 5.3 5 3 abnormal enteric ganglia morphology 0.125782830614759 0.325384603867126 0.879115479115479 0.636363636363636 5.3 5 3 abnormal eye distance/ position 0.125782830614759 0.325384603867126 0.879115479115479 0.636363636363636 5.3 5 3 impaired myelopoiesis 0.125782830614759 0.325384603867126 0.879115479115479 0.636363636363636 5.3 5 3 failure of somite differentiation 0.125782830614759 0.325384603867126 0.879115479115479 0.636363636363636 5.3 5 3 abnormal bronchiole morphology 0.125782830614759 0.325384603867126 0.879115479115479 0.636363636363636 5.3 5 3 patent ductus arteriosus 0.125782830614759 0.325384603867126 0.879115479115479 0.636363636363636 5.3 5 3 allodynia 0.125782830614759 0.325384603867126 0.879115479115479 0.636363636363636 5.3 5 3 fused joints 0.125782830614759 0.325384603867126 0.879115479115479 0.636363636363636 5.3 5 3 rectal hemorrhage 0.125782830614759 0.325384603867126 0.879115479115479 0.636363636363636 5.3 5 3 impaired luteinization 0.125782830614759 0.325384603867126 0.879115479115479 0.636363636363636 5.3 5 3 abnormal coronal suture morphology 0.125782830614759 0.325384603867126 0.879115479115479 0.636363636363636 5.3 5 3 abnormal crista ampullaris neuroepithelium morphology 0.125782830614759 0.325384603867126 0.879115479115479 0.636363636363636 5.3 5 3 cyclopia 0.125782830614759 0.325384603867126 0.879115479115479 0.636363636363636 5.3 5 3 increased motor neuron number 0.125782830614759 0.325384603867126 0.879115479115479 0.636363636363636 5.3 5 3 abnormal dorsal-ventral polarity of the somites 0.125782830614759 0.325384603867126 0.879115479115479 0.636363636363636 5.3 5 3 abnormal Bruch membrane morphology 0.125782830614759 0.325384603867126 0.879115479115479 0.636363636363636 5.3 5 3 abnormal palate development 0.125782830614759 0.325384603867126 0.879115479115479 0.636363636363636 5.3 5 3 palatal shelf hypoplasia 0.125782830614759 0.325384603867126 0.879115479115479 0.636363636363636 5.3 5 3 increased number of Howell-Jolly bodies 0.125782830614759 0.325384603867126 0.879115479115479 0.636363636363636 5.3 5 3 abnormal extraembryonic ectoderm morphology 0.125782830614759 0.325384603867126 0.879115479115479 0.636363636363636 5.3 5 3 increased pancreatic beta cell proliferation 0.125782830614759 0.325384603867126 0.879115479115479 0.636363636363636 5.3 5 3 decreased colon length 0.125782830614759 0.325384603867126 0.879115479115479 0.636363636363636 5.3 5 3 no abnormal phenotype detected 4.74946491560266e-77 1.18142939775616e-73 0.878246859457234 0.635734870317003 5.3 5 3 azoospermia 3.46218026148588e-08 1.06983520502436e-06 0.87753575678104 0.635220125786163 5.3 5 3 decreased circulating glucose level 3.62742701008495e-13 3.0587202330801e-11 0.876414663511438 0.634408602150538 5.3 5 3 thick ventricular wall 0.00459656928433167 0.0304499762843542 0.876052358979188 0.634146341463415 5.3 5 3 hemopericardium 0.00459656928433167 0.0304499762843542 0.876052358979188 0.634146341463415 5.3 5 3 small testis 5.27825817527821e-13 4.28393124873745e-11 0.875930278104191 0.634057971014493 5.3 5 3 microphthalmia 7.36452325356888e-08 2.09362875351458e-06 0.875832134655664 0.633986928104575 5.3 5 3 atelectasis 0.000224382867764214 0.00248620215395761 0.875577791070749 0.633802816901408 5.3 5 3 corneal opacity 0.000224382867764214 0.00248620215395761 0.875577791070749 0.633802816901408 5.3 5 3 abnormal skeletal muscle fiber morphology 0.000224382867764214 0.00248620215395761 0.875577791070749 0.633802816901408 5.3 5 3 decreased liver weight 0.000224382867764214 0.00248620215395761 0.875577791070749 0.633802816901408 5.3 5 3 reduced female fertility 3.95460978544671e-11 2.28769577704621e-09 0.875326188257223 0.633620689655172 5.3 5 3 intracranial hemorrhage 0.00069058370145163 0.00632717111366825 0.874929214929215 0.633333333333333 5.3 5 3 abnormal pain threshold 0.0149910519270136 0.073478308706298 0.874929214929215 0.633333333333333 5.3 5 3 abnormal cellular respiration 0.0149910519270136 0.073478308706298 0.874929214929215 0.633333333333333 5.3 5 3 increased heart weight 3.18690387731359e-07 7.81026935450005e-06 0.874597927835338 0.633093525179856 5.3 5 3 abnormal myocardium layer morphology 0.000108198847656089 0.00132583563322425 0.874346317384292 0.632911392405063 5.3 5 3 cardiac hypertrophy 1.73585804806129e-05 0.000266451949612153 0.87398944133638 0.63265306122449 5.3 5 3 increased circulating LDL cholesterol level 0.00215555775691523 0.0164729644249667 0.87398944133638 0.63265306122449 5.3 5 3 extramedullary hematopoiesis 8.45882831371024e-06 0.000142653121561724 0.873191520361332 0.632075471698113 5.3 5 3 alopecia 2.5420880453335e-05 0.000371967294868652 0.872505588295062 0.631578947368421 5.3 5 3 abnormal retinal outer nuclear layer morphology 0.00687201810431536 0.0413901816815604 0.872505588295062 0.631578947368421 5.3 5 3 abnormal compact bone morphology 0.00687201810431536 0.0413901816815604 0.872505588295062 0.631578947368421 5.3 5 3 abnormal triglyceride level 0.0516931053361914 0.181876378392894 0.872505588295062 0.631578947368421 5.3 5 3 enlarged adrenal glands 0.0516931053361914 0.181876378392894 0.872505588295062 0.631578947368421 5.3 5 3 thin dermal layer 0.0516931053361914 0.181876378392894 0.872505588295062 0.631578947368421 5.3 5 3 short vibrissae 0.0516931053361914 0.181876378392894 0.872505588295062 0.631578947368421 5.3 5 3 abnormal nasal septum morphology 0.0516931053361914 0.181876378392894 0.872505588295062 0.631578947368421 5.3 5 3 increased susceptibility to ischemic brain injury 0.0516931053361914 0.181876378392894 0.872505588295062 0.631578947368421 5.3 5 3 abnormal blastocyst morphology 0.0516931053361914 0.181876378392894 0.872505588295062 0.631578947368421 5.3 5 3 thin interventricular septum 0.0516931053361914 0.181876378392894 0.872505588295062 0.631578947368421 5.3 5 3 right-sided stomach 0.0516931053361914 0.181876378392894 0.872505588295062 0.631578947368421 5.3 5 3 abnormal hepatocyte morphology 6.03391763478062e-06 0.000105699789552935 0.871195519844169 0.630630630630631 5.3 5 3 abnormal cochlea morphology 0.00151016575982109 0.0120017167014535 0.86981266981267 0.62962962962963 5.3 5 3 abnormal chondrocyte morphology 0.00151016575982109 0.0120017167014535 0.86981266981267 0.62962962962963 5.3 5 3 abnormal mandible morphology 0.00151016575982109 0.0120017167014535 0.86981266981267 0.62962962962963 5.3 5 3 polyphagia 0.00151016575982109 0.0120017167014535 0.86981266981267 0.62962962962963 5.3 5 3 abnormal cell adhesion 0.00151016575982109 0.0120017167014535 0.86981266981267 0.62962962962963 5.3 5 3 decreased platelet aggregation 0.00151016575982109 0.0120017167014535 0.86981266981267 0.62962962962963 5.3 5 3 enlarged heart 9.51515704857469e-11 4.93103190798532e-09 0.869371588337105 0.629310344827586 5.3 5 3 abnormal dermal layer morphology 0.0102936961598414 0.0572831525673501 0.868350799779371 0.628571428571429 5.3 5 3 abnormal embryonic epiblast morphology 0.0102936961598414 0.0572831525673501 0.868350799779371 0.628571428571429 5.3 5 3 decreased triglyceride level 0.0102936961598414 0.0572831525673501 0.868350799779371 0.628571428571429 5.3 5 3 decreased glycogen level 0.0102936961598414 0.0572831525673501 0.868350799779371 0.628571428571429 5.3 5 3 male infertility 2.27064929319924e-21 4.91151314507228e-19 0.867879978814373 0.628230616302187 5.3 5 3 kinked tail 1.88086180047983e-05 0.000287033357588563 0.866802937391173 0.627450980392157 5.3 5 3 increased lung adenocarcinoma incidence 0.00223549971414227 0.0168662008286288 0.866802937391173 0.627450980392157 5.3 5 3 internal hemorrhage 0.000505432453847116 0.00490161102902417 0.865994352561517 0.626865671641791 5.3 5 3 reduced male fertility 3.14232449960366e-10 1.45623617847522e-08 0.864177708230572 0.625550660792952 5.3 5 3 decreased lymphocyte cell number 2.26764319298118e-06 4.42412740591427e-05 0.863416988416989 0.625 5.3 5 3 scoliosis 0.0154528716235923 0.0755929560741118 0.863416988416989 0.625 5.3 5 3 abnormal diaphragm morphology 0.0154528716235923 0.0755929560741118 0.863416988416989 0.625 5.3 5 3 abnormal bone marrow cell number 0.0802988972713406 0.235335824624943 0.863416988416989 0.625 5.3 5 3 decreased mast cell number 0.0802988972713406 0.235335824624943 0.863416988416989 0.625 5.3 5 3 mixed cellular infiltration to dermis 0.0802988972713406 0.235335824624943 0.863416988416989 0.625 5.3 5 3 disorganized retinal layers 0.0802988972713406 0.235335824624943 0.863416988416989 0.625 5.3 5 3 poor circulation 0.0802988972713406 0.235335824624943 0.863416988416989 0.625 5.3 5 3 abnormal olfaction 0.0802988972713406 0.235335824624943 0.863416988416989 0.625 5.3 5 3 increased pancreatic beta cell number 0.0802988972713406 0.235335824624943 0.863416988416989 0.625 5.3 5 3 decreased aggression towards mice 0.0802988972713406 0.235335824624943 0.863416988416989 0.625 5.3 5 3 small pancreas 0.0802988972713406 0.235335824624943 0.863416988416989 0.625 5.3 5 3 bowed radius 0.0802988972713406 0.235335824624943 0.863416988416989 0.625 5.3 5 3 decreased circulating growth hormone level 0.0802988972713406 0.235335824624943 0.863416988416989 0.625 5.3 5 3 decreased creatinine clearance 0.0802988972713406 0.235335824624943 0.863416988416989 0.625 5.3 5 3 kidney degeneration 0.0802988972713406 0.235335824624943 0.863416988416989 0.625 5.3 5 3 decreased liver cholesterol level 0.0802988972713406 0.235335824624943 0.863416988416989 0.625 5.3 5 3 decreased skeletal muscle weight 0.0802988972713406 0.235335824624943 0.863416988416989 0.625 5.3 5 3 decreased midbrain size 0.0802988972713406 0.235335824624943 0.863416988416989 0.625 5.3 5 3 abnormal bone marrow development 0.205983493906677 0.415076319463109 0.863416988416989 0.625 5.3 5 3 failure of vascular branching 0.205983493906677 0.415076319463109 0.863416988416989 0.625 5.3 5 3 schistocytosis 0.205983493906677 0.415076319463109 0.863416988416989 0.625 5.3 5 3 pointed snout 0.205983493906677 0.415076319463109 0.863416988416989 0.625 5.3 5 3 clubfoot 0.205983493906677 0.415076319463109 0.863416988416989 0.625 5.3 5 3 absent mammary gland 0.205983493906677 0.415076319463109 0.863416988416989 0.625 5.3 5 3 absent eyelids 0.205983493906677 0.415076319463109 0.863416988416989 0.625 5.3 5 3 unidirectional circling 0.205983493906677 0.415076319463109 0.863416988416989 0.625 5.3 5 3 spinning 0.205983493906677 0.415076319463109 0.863416988416989 0.625 5.3 5 3 abnormal urination 0.205983493906677 0.415076319463109 0.863416988416989 0.625 5.3 5 3 abnormal atrial thrombosis 0.205983493906677 0.415076319463109 0.863416988416989 0.625 5.3 5 3 abnormal pulmonary circulation 0.205983493906677 0.415076319463109 0.863416988416989 0.625 5.3 5 3 abnormal thyroid physiology 0.205983493906677 0.415076319463109 0.863416988416989 0.625 5.3 5 3 decreased corneal stroma thickness 0.205983493906677 0.415076319463109 0.863416988416989 0.625 5.3 5 3 decreased susceptibility to age related obesity 0.205983493906677 0.415076319463109 0.863416988416989 0.625 5.3 5 3 abnormal umbilical artery morphology 0.205983493906677 0.415076319463109 0.863416988416989 0.625 5.3 5 3 liver failure 0.205983493906677 0.415076319463109 0.863416988416989 0.625 5.3 5 3 liver cysts 0.205983493906677 0.415076319463109 0.863416988416989 0.625 5.3 5 3 binucleate 0.205983493906677 0.415076319463109 0.863416988416989 0.625 5.3 5 3 abnormal miscarriage rate 0.205983493906677 0.415076319463109 0.863416988416989 0.625 5.3 5 3 absent cochlear microphonics 0.205983493906677 0.415076319463109 0.863416988416989 0.625 5.3 5 3 abnormal choroid pigmentation 0.205983493906677 0.415076319463109 0.863416988416989 0.625 5.3 5 3 non-pigmented tail tip 0.205983493906677 0.415076319463109 0.863416988416989 0.625 5.3 5 3 abnormal canal of Schlemm morphology 0.205983493906677 0.415076319463109 0.863416988416989 0.625 5.3 5 3 ocular hypertension 0.205983493906677 0.415076319463109 0.863416988416989 0.625 5.3 5 3 choroidal neovascularization 0.205983493906677 0.415076319463109 0.863416988416989 0.625 5.3 5 3 increased pulmonary ventilation 0.205983493906677 0.415076319463109 0.863416988416989 0.625 5.3 5 3 hypergranulosis 0.205983493906677 0.415076319463109 0.863416988416989 0.625 5.3 5 3 abnormal epidermal lamellar body morphology 0.205983493906677 0.415076319463109 0.863416988416989 0.625 5.3 5 3 enlarged inguinal lymph nodes 0.205983493906677 0.415076319463109 0.863416988416989 0.625 5.3 5 3 impaired behavioral response to alcohol 0.205983493906677 0.415076319463109 0.863416988416989 0.625 5.3 5 3 skin fibrosis 0.205983493906677 0.415076319463109 0.863416988416989 0.625 5.3 5 3 pleural effusion 0.205983493906677 0.415076319463109 0.863416988416989 0.625 5.3 5 3 ostium secundum atrial septal defect 0.205983493906677 0.415076319463109 0.863416988416989 0.625 5.3 5 3 anomalous pulmonary venous connection 0.205983493906677 0.415076319463109 0.863416988416989 0.625 5.3 5 3 increased heart right ventricle size 0.205983493906677 0.415076319463109 0.863416988416989 0.625 5.3 5 3 abnormal heart right ventricle pressure 0.205983493906677 0.415076319463109 0.863416988416989 0.625 5.3 5 3 abnormal stomach position or orientation 0.205983493906677 0.415076319463109 0.863416988416989 0.625 5.3 5 3 lung situs inversus 0.205983493906677 0.415076319463109 0.863416988416989 0.625 5.3 5 3 decreased alveolar lamellar body number 0.205983493906677 0.415076319463109 0.863416988416989 0.625 5.3 5 3 absent ureteric bud 0.205983493906677 0.415076319463109 0.863416988416989 0.625 5.3 5 3 abnormal macrophage activation involved in immune response 0.205983493906677 0.415076319463109 0.863416988416989 0.625 5.3 5 3 lethality during fetal growth through weaning, incomplete penetrance 0.205983493906677 0.415076319463109 0.863416988416989 0.625 5.3 5 3 absent Reichert's membrane 0.205983493906677 0.415076319463109 0.863416988416989 0.625 5.3 5 3 increased circulating ferritin level 0.205983493906677 0.415076319463109 0.863416988416989 0.625 5.3 5 3 increased cardiac stroke volume 0.205983493906677 0.415076319463109 0.863416988416989 0.625 5.3 5 3 prolonged PQ interval 0.205983493906677 0.415076319463109 0.863416988416989 0.625 5.3 5 3 increased circulating lactate level 0.205983493906677 0.415076319463109 0.863416988416989 0.625 5.3 5 3 decreased white adipose tissue mass 0.205983493906677 0.415076319463109 0.863416988416989 0.625 5.3 5 3 abnormal malleus morphology 0.0344801358460743 0.133285684408873 0.863416988416988 0.625 5.3 5 3 apnea 0.0344801358460743 0.133285684408873 0.863416988416988 0.625 5.3 5 3 prolonged QT interval 0.0344801358460743 0.133285684408873 0.863416988416988 0.625 5.3 5 3 decreased ovulation rate 0.0344801358460743 0.133285684408873 0.863416988416988 0.625 5.3 5 3 abnormal retinal ganglion layer morphology 0.0344801358460743 0.133285684408873 0.863416988416988 0.625 5.3 5 3 decreased fatty acid level 0.0344801358460743 0.133285684408873 0.863416988416988 0.625 5.3 5 3 increased body temperature 0.0344801358460743 0.133285684408873 0.863416988416988 0.625 5.3 5 3 abnormal truncus arteriosus septation 0.0344801358460743 0.133285684408873 0.863416988416988 0.625 5.3 5 3 abnormal retinal pigment epithelium morphology 0.000171296394436453 0.00196812831944886 0.863416988416988 0.625 5.3 5 3 abnormal skin pigmentation 0.00709703919748438 0.0424882912244101 0.863416988416988 0.625 5.3 5 3 circling 0.000121009759465114 0.00144024773526063 0.861385419032478 0.623529411764706 5.3 5 3 abnormal pancreatic islet morphology 0.00230676713913613 0.0172056469523272 0.860158811102207 0.622641509433962 5.3 5 3 abnormal autopod morphology 0.00490991472017096 0.0323963206005976 0.85957957957958 0.622222222222222 5.3 5 3 sparse hair 0.000176920147339402 0.00202805929265789 0.859205198229588 0.621951219512195 5.3 5 3 impaired skeletal muscle contractility 0.0105857944098038 0.0586732314528384 0.85874986956068 0.621621621621622 5.3 5 3 enlarged spleen 3.74107373672195e-12 2.54956737536872e-10 0.858620227370227 0.621527777777778 5.3 5 3 abnormal outer ear morphology 0.0232559606952699 0.105276073211072 0.857462388496871 0.620689655172414 5.3 5 3 short sternum 0.0232559606952699 0.105276073211072 0.857462388496871 0.620689655172414 5.3 5 3 female infertility 3.20292160064745e-11 1.8969684480025e-09 0.856925131361222 0.620300751879699 5.3 5 3 decreased double-positive T cell number 4.27684200718082e-05 0.000587770413970293 0.856509652509653 0.62 5.3 5 3 abnormal hindlimb morphology 0.00340673624727772 0.0241431806698101 0.856509652509653 0.62 5.3 5 3 abnormal digestive system physiology 0.00340673624727772 0.0241431806698101 0.856509652509653 0.62 5.3 5 3 kidney inflammation 0.00340673624727772 0.0241431806698101 0.856509652509653 0.62 5.3 5 3 abnormal eye electrophysiology 7.19724932921582e-06 0.000122339109056076 0.856281310826765 0.619834710743802 5.3 5 3 abnormal optic nerve morphology 0.00728564634503745 0.0435127137653797 0.855193969479684 0.619047619047619 5.3 5 3 abnormal associative learning 0.0526539035840886 0.184344243723322 0.855193969479684 0.619047619047619 5.3 5 3 liver degeneration 0.0526539035840886 0.184344243723322 0.855193969479684 0.619047619047619 5.3 5 3 abnormal erythrocyte physiology 0.0526539035840886 0.184344243723322 0.855193969479684 0.619047619047619 5.3 5 3 abnormal stapes morphology 0.0526539035840886 0.184344243723322 0.855193969479684 0.619047619047619 5.3 5 3 abnormal tumor vascularization 0.0526539035840886 0.184344243723322 0.855193969479684 0.619047619047619 5.3 5 3 increased muscle cell glucose uptake 0.0526539035840886 0.184344243723322 0.855193969479684 0.619047619047619 5.3 5 3 short maxilla 0.0158138722904222 0.0770558419636143 0.853259141494436 0.617647058823529 5.3 5 3 abnormal oocyte morphology 0.0158138722904222 0.0770558419636143 0.853259141494436 0.617647058823529 5.3 5 3 increased width of hypertrophic chondrocyte zone 0.0158138722904222 0.0770558419636143 0.853259141494436 0.617647058823529 5.3 5 3 hepatic necrosis 0.00503357883516083 0.0331682843773843 0.852394643884006 0.617021276595745 5.3 5 3 increased circulating glucose level 1.82662306116888e-06 3.67912944506687e-05 0.852394643884006 0.617021276595745 5.3 5 3 abnormal eye physiology 0.00165189890111523 0.0129420425717296 0.851904761904762 0.616666666666667 5.3 5 3 decreased B-1 B cell number 0.0108206663394429 0.0594181181442916 0.85013365013365 0.615384615384615 5.3 5 3 increased thermal nociceptive threshold 0.000131802919292474 0.0015612369606668 0.85013365013365 0.615384615384615 5.3 5 3 abnormal snout morphology 0.00348877778248781 0.024377344758254 0.85013365013365 0.615384615384615 5.3 5 3 decreased kidney weight 0.00348877778248781 0.024377344758254 0.85013365013365 0.615384615384615 5.3 5 3 increased susceptibility to otitis media 0.0351002431326847 0.135367216732641 0.85013365013365 0.615384615384615 5.3 5 3 abnormal Mullerian duct morphology 0.0351002431326847 0.135367216732641 0.85013365013365 0.615384615384615 5.3 5 3 short premaxilla 0.126164201177827 0.325384603867126 0.85013365013365 0.615384615384615 5.3 5 3 absent trabeculae carneae 0.126164201177827 0.325384603867126 0.85013365013365 0.615384615384615 5.3 5 3 small trigeminal ganglion 0.126164201177827 0.325384603867126 0.85013365013365 0.615384615384615 5.3 5 3 increased pituitary adenoma incidence 0.126164201177827 0.325384603867126 0.85013365013365 0.615384615384615 5.3 5 3 abnormal pulmonary alveolus epithelial cell morphology 0.126164201177827 0.325384603867126 0.85013365013365 0.615384615384615 5.3 5 3 abnormal otolith morphology 0.126164201177827 0.325384603867126 0.85013365013365 0.615384615384615 5.3 5 3 abnormal soleus morphology 0.126164201177827 0.325384603867126 0.85013365013365 0.615384615384615 5.3 5 3 abnormal telomere length 0.126164201177827 0.325384603867126 0.85013365013365 0.615384615384615 5.3 5 3 muscle fatigue 0.126164201177827 0.325384603867126 0.85013365013365 0.615384615384615 5.3 5 3 small otic vesicle 0.126164201177827 0.325384603867126 0.85013365013365 0.615384615384615 5.3 5 3 vestibular hair cell degeneration 0.126164201177827 0.325384603867126 0.85013365013365 0.615384615384615 5.3 5 3 increased prostaglandin level 0.126164201177827 0.325384603867126 0.85013365013365 0.615384615384615 5.3 5 3 abnormal aorta tunica media morphology 0.126164201177827 0.325384603867126 0.85013365013365 0.615384615384615 5.3 5 3 decreased T cell number 4.64763296049274e-07 1.11163336434862e-05 0.84947360847982 0.614906832298137 5.3 5 3 abnormal heart morphology 1.76024021972453e-09 6.89542920718863e-08 0.849213592070735 0.614718614718615 5.3 5 3 abnormal vertebrae morphology 3.19164470123215e-05 0.000454969409416331 0.849158726222946 0.614678899082569 5.3 5 3 abnormal blood homeostasis 2.25643288108973e-05 0.000339146633940224 0.848269321953532 0.614035087719298 5.3 5 3 teratozoospermia 0.000191666396140562 0.00218201446407162 0.847718497718498 0.613636363636364 5.3 5 3 abnormal circadian rhythm 0.00744075945423175 0.0442267363020346 0.847718497718498 0.613636363636364 5.3 5 3 abnormal astrocyte morphology 0.00744075945423175 0.0442267363020346 0.847718497718498 0.613636363636364 5.3 5 3 abnormal photoreceptor outer segment morphology 0.00744075945423175 0.0442267363020346 0.847718497718498 0.613636363636364 5.3 5 3 abnormal cranial ganglia morphology 0.0236640366032087 0.106670702504151 0.846705691866982 0.612903225806452 5.3 5 3 decreased double-negative T cell number 0.0236640366032087 0.106670702504151 0.846705691866982 0.612903225806452 5.3 5 3 organ of Corti degeneration 0.00513717375135982 0.0334959887457603 0.845796233551336 0.612244897959184 5.3 5 3 decreased circulating creatinine level 0.00513717375135982 0.0334959887457603 0.845796233551336 0.612244897959184 5.3 5 3 abnormal enzyme/coenzyme activity 9.9091965158663e-07 2.20081485118013e-05 0.84471878612006 0.611464968152866 5.3 5 3 diluted coat color 0.00355856930663121 0.024830129453703 0.844229944229944 0.611111111111111 5.3 5 3 narrow eye opening 0.0160860613285821 0.0783054355280782 0.844229944229944 0.611111111111111 5.3 5 3 right pulmonary isomerism 0.0808892985143021 0.235335824624943 0.844229944229944 0.611111111111111 5.3 5 3 abnormal mammary gland morphology 0.0808892985143021 0.235335824624943 0.844229944229944 0.611111111111111 5.3 5 3 abnormal thyroid cartilage morphology 0.0808892985143021 0.235335824624943 0.844229944229944 0.611111111111111 5.3 5 3 abnormal thymus cortex morphology 0.0808892985143021 0.235335824624943 0.844229944229944 0.611111111111111 5.3 5 3 abnormal thymus medulla morphology 0.0808892985143021 0.235335824624943 0.844229944229944 0.611111111111111 5.3 5 3 absent allantois 0.0808892985143021 0.235335824624943 0.844229944229944 0.611111111111111 5.3 5 3 abnormal redox activity 0.0808892985143021 0.235335824624943 0.844229944229944 0.611111111111111 5.3 5 3 abnormal anterior eye segment morphology 0.0808892985143021 0.235335824624943 0.844229944229944 0.611111111111111 5.3 5 3 scaly skin 0.0110040234367855 0.0603583424454331 0.842358037479989 0.609756097560976 5.3 5 3 respiratory failure 2.05651063001068e-06 4.04392900565341e-05 0.841688613874044 0.609271523178808 5.3 5 3 abnormal forelimb morphology 0.00756521375710215 0.0448058790971229 0.840893066980024 0.608695652173913 5.3 5 3 abnormal sleep pattern 0.00756521375710215 0.0448058790971229 0.840893066980024 0.608695652173913 5.3 5 3 abnormal allantois morphology 0.00756521375710215 0.0448058790971229 0.840893066980024 0.608695652173913 5.3 5 3 abnormal blood vessel physiology 0.0531535618114767 0.184664085203978 0.840893066980024 0.608695652173913 5.3 5 3 abnormal postnatal growth 0.0531535618114767 0.184664085203978 0.840893066980024 0.608695652173913 5.3 5 3 abnormal nasal cavity morphology 0.0531535618114767 0.184664085203978 0.840893066980024 0.608695652173913 5.3 5 3 abnormal cochlear ganglion morphology 0.0531535618114767 0.184664085203978 0.840893066980024 0.608695652173913 5.3 5 3 decreased epididymis weight 0.0531535618114767 0.184664085203978 0.840893066980024 0.608695652173913 5.3 5 3 decreased effector memory CD8-positive, alpha-beta T cell number 0.0531535618114767 0.184664085203978 0.840893066980024 0.608695652173913 5.3 5 3 decreased spleen weight 0.00120099670690809 0.00989231559084068 0.840893066980024 0.608695652173913 5.3 5 3 abnormal myocardial fiber morphology 0.000140514005877161 0.00165653360009212 0.840273852644987 0.608247422680412 5.3 5 3 impaired hematopoiesis 0.00522215287363769 0.0336967711366375 0.839715345597699 0.607843137254902 5.3 5 3 short mandible 0.00361687445591096 0.0252016112299118 0.838747931605075 0.607142857142857 5.3 5 3 abnormal jaw morphology 0.0354768934083293 0.136291540313852 0.838747931605075 0.607142857142857 5.3 5 3 small superior cervical ganglion 0.0354768934083293 0.136291540313852 0.838747931605075 0.607142857142857 5.3 5 3 abnormal respiration 0.0354768934083293 0.136291540313852 0.838747931605075 0.607142857142857 5.3 5 3 corneal vascularization 0.0354768934083293 0.136291540313852 0.838747931605075 0.607142857142857 5.3 5 3 decreased B cell number 4.72250498698736e-08 1.41532905483507e-06 0.838268920793193 0.606796116504854 5.3 5 3 increased double-negative T cell number 0.00251212611867388 0.0184769034366881 0.837939110070258 0.60655737704918 5.3 5 3 belly spot 0.023936800338335 0.106670702504151 0.837252837252837 0.606060606060606 5.3 5 3 abnormal ovarian folliculogenesis 0.023936800338335 0.106670702504151 0.837252837252837 0.606060606060606 5.3 5 3 abnormal renal glomerulus morphology 7.09179523942593e-05 0.000916407306912831 0.836484715383798 0.605504587155963 5.3 5 3 increased bone marrow cell number 0.0162802514115527 0.0788648985126335 0.836151188782768 0.605263157894737 5.3 5 3 decreased hair follicle number 0.0162802514115527 0.0788648985126335 0.836151188782768 0.605263157894737 5.3 5 3 decreased threshold for auditory brainstem response 0.0162802514115527 0.0788648985126335 0.836151188782768 0.605263157894737 5.3 5 3 decreased litter size 2.81572870759103e-10 1.32153304908164e-08 0.835763063521071 0.604982206405694 5.3 5 3 abnormal organ of Corti morphology 0.0111411787538396 0.0607068925997698 0.835305737631319 0.604651162790698 5.3 5 3 abnormal blood circulation 0.0111411787538396 0.0607068925997698 0.835305737631319 0.604651162790698 5.3 5 3 abnormal osteoclast morphology 0.00766171797506205 0.0453234802924301 0.834636422136422 0.604166666666667 5.3 5 3 glomerulosclerosis 0.00366445501732596 0.0253971304457012 0.833643988816403 0.603448275862069 5.3 5 3 abnormal liver morphology 5.57099155924865e-07 1.29512537417112e-05 0.833510925131037 0.603351955307263 5.3 5 3 decreased susceptibility to hepatic steatosis 0.00254552350340011 0.0186234991609052 0.833265918980205 0.603174603174603 5.3 5 3 decreased bone marrow cell number 0.00123670638300107 0.0101696103395543 0.83266515047337 0.602739726027397 5.3 5 3 increased rib number 0.000864434407053367 0.0077070988800905 0.832422532422532 0.602564102564103 5.3 5 3 short femur 0.000424254503447786 0.00423828545110991 0.832020007020007 0.602272727272727 5.3 5 3 abnormal definitive hematopoiesis 0.0002977898513413 0.00318603120521069 0.831851206044754 0.602150537634409 5.3 5 3 decreased circulating calcium level 0.00534189600827836 0.034155233340243 0.828880308880309 0.6 5.3 5 3 abnormal inner ear vestibule morphology 0.0532936951319957 0.184892701033249 0.828880308880309 0.6 5.3 5 3 increased liver glycogen level 0.0532936951319957 0.184892701033249 0.828880308880309 0.6 5.3 5 3 increased inflammatory response 0.000301336841829644 0.00321509901458992 0.828880308880309 0.6 5.3 5 3 abnormal long bone epiphyseal plate morphology 0.00370205967917184 0.0255791375209371 0.828880308880309 0.6 5.3 5 3 abnormal cartilage development 0.011237026555323 0.0607068925997698 0.828880308880309 0.6 5.3 5 3 albuminuria 0.011237026555323 0.0607068925997698 0.828880308880309 0.6 5.3 5 3 cardiomyopathy 0.011237026555323 0.0607068925997698 0.828880308880309 0.6 5.3 5 3 decreased circulating phosphate level 0.0164061070523805 0.0789485403884832 0.828880308880309 0.6 5.3 5 3 thick pulmonary interalveolar septum 0.0240941364862933 0.106670702504151 0.828880308880309 0.6 5.3 5 3 abnormal intestinal goblet cell morphology 0.0240941364862933 0.106670702504151 0.828880308880309 0.6 5.3 5 3 decreased circulating thyroxine level 0.0240941364862933 0.106670702504151 0.828880308880309 0.6 5.3 5 3 impaired adaptive thermogenesis 0.0240941364862933 0.106670702504151 0.828880308880309 0.6 5.3 5 3 emphysema 0.0356533238476546 0.136592167762821 0.828880308880309 0.6 5.3 5 3 disorganized myocardium 0.0356533238476546 0.136592167762821 0.828880308880309 0.6 5.3 5 3 abnormal basioccipital bone morphology 0.0808038325897207 0.235335824624943 0.828880308880309 0.6 5.3 5 3 abnormal hyoid bone morphology 0.0808038325897207 0.235335824624943 0.828880308880309 0.6 5.3 5 3 abnormal lens epithelium morphology 0.0808038325897207 0.235335824624943 0.828880308880309 0.6 5.3 5 3 abnormal physiological neovascularization 0.0808038325897207 0.235335824624943 0.828880308880309 0.6 5.3 5 3 abnormal optic stalk morphology 0.0808038325897207 0.235335824624943 0.828880308880309 0.6 5.3 5 3 dilated vasculature 0.0808038325897207 0.235335824624943 0.828880308880309 0.6 5.3 5 3 abnormal incus morphology 0.0808038325897207 0.235335824624943 0.828880308880309 0.6 5.3 5 3 abnormal heart electrocardiography waveform feature 0.0808038325897207 0.235335824624943 0.828880308880309 0.6 5.3 5 3 decreased muscle cell glucose uptake 0.0808038325897207 0.235335824624943 0.828880308880309 0.6 5.3 5 3 abnormal fontanelle morphology 0.125199242111216 0.325384603867126 0.828880308880309 0.6 5.3 5 3 decreased salivation 0.125199242111216 0.325384603867126 0.828880308880309 0.6 5.3 5 3 abnormal apical ectodermal ridge morphology 0.125199242111216 0.325384603867126 0.828880308880309 0.6 5.3 5 3 increased airway responsiveness 0.125199242111216 0.325384603867126 0.828880308880309 0.6 5.3 5 3 abnormal rostral migratory stream morphology 0.125199242111216 0.325384603867126 0.828880308880309 0.6 5.3 5 3 abnormal Muller cell morphology 0.125199242111216 0.325384603867126 0.828880308880309 0.6 5.3 5 3 absent chorion 0.125199242111216 0.325384603867126 0.828880308880309 0.6 5.3 5 3 abnormal aorta wall morphology 0.125199242111216 0.325384603867126 0.828880308880309 0.6 5.3 5 3 liver vascular congestion 0.125199242111216 0.325384603867126 0.828880308880309 0.6 5.3 5 3 bicuspid aortic valve 0.125199242111216 0.325384603867126 0.828880308880309 0.6 5.3 5 3 herniated liver 0.125199242111216 0.325384603867126 0.828880308880309 0.6 5.3 5 3 abnormal lateral semicircular canal morphology 0.201406483088342 0.415076319463109 0.828880308880309 0.6 5.3 5 3 absent maxillary shelf 0.201406483088342 0.415076319463109 0.828880308880309 0.6 5.3 5 3 abnormal grooming behavior 0.201406483088342 0.415076319463109 0.828880308880309 0.6 5.3 5 3 abnormal pituitary secretion 0.201406483088342 0.415076319463109 0.828880308880309 0.6 5.3 5 3 ketoaciduria 0.201406483088342 0.415076319463109 0.828880308880309 0.6 5.3 5 3 abnormal bone healing 0.201406483088342 0.415076319463109 0.828880308880309 0.6 5.3 5 3 abnormal tibialis anterior morphology 0.201406483088342 0.415076319463109 0.828880308880309 0.6 5.3 5 3 aneurysm 0.201406483088342 0.415076319463109 0.828880308880309 0.6 5.3 5 3 abnormal hypaxial muscle morphology 0.201406483088342 0.415076319463109 0.828880308880309 0.6 5.3 5 3 cochlear ganglion hypoplasia 0.201406483088342 0.415076319463109 0.828880308880309 0.6 5.3 5 3 abnormal submandibular gland morphology 0.201406483088342 0.415076319463109 0.828880308880309 0.6 5.3 5 3 abnormal embryonic erythrocyte morphology 0.201406483088342 0.415076319463109 0.828880308880309 0.6 5.3 5 3 abnormal utricular macula morphology 0.201406483088342 0.415076319463109 0.828880308880309 0.6 5.3 5 3 abnormal cochlear inner hair cell physiology 0.201406483088342 0.415076319463109 0.828880308880309 0.6 5.3 5 3 abnormal corneal endothelium morphology 0.201406483088342 0.415076319463109 0.828880308880309 0.6 5.3 5 3 tachypnea 0.201406483088342 0.415076319463109 0.828880308880309 0.6 5.3 5 3 decreased thyroxine level 0.201406483088342 0.415076319463109 0.828880308880309 0.6 5.3 5 3 abnormal developmental vascular remodeling 0.201406483088342 0.415076319463109 0.828880308880309 0.6 5.3 5 3 ventricular premature beat 0.201406483088342 0.415076319463109 0.828880308880309 0.6 5.3 5 3 umbilical hernia 0.201406483088342 0.415076319463109 0.828880308880309 0.6 5.3 5 3 acanthocytosis 0.201406483088342 0.415076319463109 0.828880308880309 0.6 5.3 5 3 increased T-helper 17 cell number 0.201406483088342 0.415076319463109 0.828880308880309 0.6 5.3 5 3 increased kidney iron level 0.201406483088342 0.415076319463109 0.828880308880309 0.6 5.3 5 3 aorta stenosis 0.201406483088342 0.415076319463109 0.828880308880309 0.6 5.3 5 3 sinus bradycardia 0.201406483088342 0.415076319463109 0.828880308880309 0.6 5.3 5 3 decreased circulating lactate level 0.201406483088342 0.415076319463109 0.828880308880309 0.6 5.3 5 3 abnormal spleen morphology 1.66788134069221e-06 3.45737902914323e-05 0.825704522256246 0.597701149425287 5.3 5 3 abnormal retinal pigmentation 0.000618136027420058 0.00574808735778465 0.825704522256246 0.597701149425287 5.3 5 3 abnormal response/metabolism to endogenous compounds 0.000882523965908249 0.00785430542109757 0.825510876730389 0.597560975609756 5.3 5 3 decreased compact bone thickness 0.00259367869097551 0.0189479463841456 0.824756526249063 0.597014925373134 5.3 5 3 abnormal circulating amino acid level 0.00537933889961534 0.034155233340243 0.824033055612003 0.596491228070175 5.3 5 3 abnormal T-helper 1 physiology 0.0112960441683841 0.0607068925997698 0.823001725129385 0.595744680851064 5.3 5 3 hydronephrosis 0.000889194831448372 0.00787143111468977 0.822301893730465 0.595238095238095 5.3 5 3 skin edema 0.0164722250422973 0.0791689078620019 0.822301893730465 0.595238095238095 5.3 5 3 abnormal response to infection 0.00127085196492809 0.0104159613270465 0.821885538341235 0.594936708860759 5.3 5 3 decreased food intake 0.00127085196492809 0.0104159613270465 0.821885538341235 0.594936708860759 5.3 5 3 increased white adipose tissue amount 0.0241531194761235 0.106670702504151 0.821412918710216 0.594594594594595 5.3 5 3 abnormal pancreatic beta cell physiology 0.0241531194761235 0.106670702504151 0.821412918710216 0.594594594594595 5.3 5 3 abnormal coat appearance 0.00260924770438367 0.019033735086963 0.820871803480499 0.594202898550725 5.3 5 3 abnormal cardiovascular system physiology 3.8172931445679e-05 0.000533455994219811 0.820570731848927 0.593984962406015 5.3 5 3 polydipsia 0.0356649700349557 0.136592167762821 0.820246138996139 0.59375 5.3 5 3 abnormal serotonin level 0.0356649700349557 0.136592167762821 0.820246138996139 0.59375 5.3 5 3 small spleen 0.000626988100904059 0.0058195257499957 0.819771734057448 0.593406593406593 5.3 5 3 abnormal colon morphology 0.00540350556626692 0.034155233340243 0.819514429683921 0.593220338983051 5.3 5 3 increased oxygen consumption 0.000894389385716015 0.00788722913213601 0.819242165753794 0.593023255813954 5.3 5 3 abnormal heart valve morphology 0.053152296004415 0.184664085203978 0.818647218647219 0.592592592592593 5.3 5 3 rectal prolapse 0.053152296004415 0.184664085203978 0.818647218647219 0.592592592592593 5.3 5 3 cryptorchism 0.053152296004415 0.184664085203978 0.818647218647219 0.592592592592593 5.3 5 3 improved glucose tolerance 8.80451095020404e-07 1.96423506624507e-05 0.817603025766291 0.591836734693878 5.3 5 3 abnormal skin morphology 0.00376215580840454 0.0258840660061891 0.816321516321516 0.590909090909091 5.3 5 3 hypertension 0.0164862288532732 0.0791689078620019 0.816321516321516 0.590909090909091 5.3 5 3 intestinal inflammation 0.0802287059787649 0.235335824624943 0.816321516321516 0.590909090909091 5.3 5 3 abnormal retinal outer plexiform layer morphology 0.0802287059787649 0.235335824624943 0.816321516321516 0.590909090909091 5.3 5 3 rough coat 0.0802287059787649 0.235335824624943 0.816321516321516 0.590909090909091 5.3 5 3 spleen hypoplasia 0.000312352803247108 0.00330295855056247 0.815723478580621 0.59047619047619 5.3 5 3 increased monocyte cell number 0.000444121754391739 0.0044101910740497 0.815065637065637 0.59 5.3 5 3 abnormal circulating hormone level 0.0241284049527106 0.106670702504151 0.814711414711415 0.58974358974359 5.3 5 3 abnormal eye development 0.00781692693124029 0.0456446144165733 0.814078874793161 0.589285714285714 5.3 5 3 weight loss 4.94869756273079e-06 8.76148411906964e-05 0.813092112520684 0.588571428571429 5.3 5 3 decreased circulating alanine transaminase level 0.00376684699265948 0.0258840660061891 0.812627753804224 0.588235294117647 5.3 5 3 hydroureter 0.123387005203086 0.325384603867126 0.812627753804224 0.588235294117647 5.3 5 3 distended urinary bladder 0.123387005203086 0.325384603867126 0.812627753804224 0.588235294117647 5.3 5 3 increased incidence of corneal inflammation 0.123387005203086 0.325384603867126 0.812627753804224 0.588235294117647 5.3 5 3 abnormal duodenum morphology 0.123387005203086 0.325384603867126 0.812627753804224 0.588235294117647 5.3 5 3 abnormal melanosome morphology 0.123387005203086 0.325384603867126 0.812627753804224 0.588235294117647 5.3 5 3 common atrium 0.123387005203086 0.325384603867126 0.812627753804224 0.588235294117647 5.3 5 3 abnormal survival 0.123387005203086 0.325384603867126 0.812627753804224 0.588235294117647 5.3 5 3 decreased body fat mass 0.123387005203086 0.325384603867126 0.812627753804224 0.588235294117647 5.3 5 3 abnormal cell cytoskeleton morphology 0.123387005203086 0.325384603867126 0.812627753804224 0.588235294117647 5.3 5 3 abnormal gastrulation 0.0113195116272619 0.0607068925997698 0.812627753804224 0.588235294117647 5.3 5 3 abnormal gluconeogenesis 0.0113195116272619 0.0607068925997698 0.812627753804224 0.588235294117647 5.3 5 3 increased kidney weight 0.0113195116272619 0.0607068925997698 0.812627753804224 0.588235294117647 5.3 5 3 cochlear inner hair cell degeneration 0.0113195116272619 0.0607068925997698 0.812627753804224 0.588235294117647 5.3 5 3 increased leukocyte cell number 3.9122558891845e-05 0.000543672431527735 0.809825589135934 0.586206896551724 5.3 5 3 focal hair loss 0.0527898814184973 0.18456054817781 0.809825589135934 0.586206896551724 5.3 5 3 increased retinal apoptosis 0.0527898814184973 0.18456054817781 0.809825589135934 0.586206896551724 5.3 5 3 deafness 0.000633879902126184 0.00587253726830124 0.809344409344409 0.585858585858586 5.3 5 3 abnormal mammary gland development 0.0240325780391029 0.106670702504151 0.808663715980789 0.585365853658537 5.3 5 3 short humerus 0.0240325780391029 0.106670702504151 0.808663715980789 0.585365853658537 5.3 5 3 short ulna 0.0240325780391029 0.106670702504151 0.808663715980789 0.585365853658537 5.3 5 3 abnormal cholesterol homeostasis 0.0240325780391029 0.106670702504151 0.808663715980789 0.585365853658537 5.3 5 3 abnormal coat/ hair morphology 0.0112910011439689 0.0607068925997698 0.80802797406571 0.584905660377358 5.3 5 3 abnormal lipid homeostasis 0.00011054830188769 0.00133117580454667 0.807626967626968 0.584615384615385 5.3 5 3 cochlear outer hair cell degeneration 0.00375688842321874 0.0258840660061891 0.805855855855856 0.583333333333333 5.3 5 3 abnormal cardiovascular system morphology 0.0163841008390348 0.0789485403884832 0.805855855855856 0.583333333333333 5.3 5 3 impaired wound healing 0.035305441707089 0.136053115796102 0.805855855855856 0.583333333333333 5.3 5 3 abnormal foregut morphology 0.0792963581630399 0.235335824624943 0.805855855855856 0.583333333333333 5.3 5 3 small lymph nodes 0.0792963581630399 0.235335824624943 0.805855855855856 0.583333333333333 5.3 5 3 abnormal cardiac muscle contractility 0.0792963581630399 0.235335824624943 0.805855855855856 0.583333333333333 5.3 5 3 abnormal osteoblast morphology 0.0792963581630399 0.235335824624943 0.805855855855856 0.583333333333333 5.3 5 3 abnormal esophagus morphology 0.195637205416663 0.415076319463109 0.805855855855856 0.583333333333333 5.3 5 3 decreased digestive secretion 0.195637205416663 0.415076319463109 0.805855855855856 0.583333333333333 5.3 5 3 abnormal superior cervical ganglion morphology 0.195637205416663 0.415076319463109 0.805855855855856 0.583333333333333 5.3 5 3 ear inflammation 0.195637205416663 0.415076319463109 0.805855855855856 0.583333333333333 5.3 5 3 delayed somite formation 0.195637205416663 0.415076319463109 0.805855855855856 0.583333333333333 5.3 5 3 vestibular saccular macula degeneration 0.195637205416663 0.415076319463109 0.805855855855856 0.583333333333333 5.3 5 3 stria vascularis degeneration 0.195637205416663 0.415076319463109 0.805855855855856 0.583333333333333 5.3 5 3 abnormal cochlear outer hair cell physiology 0.195637205416663 0.415076319463109 0.805855855855856 0.583333333333333 5.3 5 3 abnormal B cell proliferation 0.195637205416663 0.415076319463109 0.805855855855856 0.583333333333333 5.3 5 3 abnormal anogenital distance 0.195637205416663 0.415076319463109 0.805855855855856 0.583333333333333 5.3 5 3 abnormal amacrine cell morphology 0.195637205416663 0.415076319463109 0.805855855855856 0.583333333333333 5.3 5 3 abnormal fatty acid level 0.195637205416663 0.415076319463109 0.805855855855856 0.583333333333333 5.3 5 3 decreased keratinocyte proliferation 0.195637205416663 0.415076319463109 0.805855855855856 0.583333333333333 5.3 5 3 hydrometra 0.195637205416663 0.415076319463109 0.805855855855856 0.583333333333333 5.3 5 3 decreased prostaglandin level 0.195637205416663 0.415076319463109 0.805855855855856 0.583333333333333 5.3 5 3 abnormal aorta elastic tissue morphology 0.195637205416663 0.415076319463109 0.805855855855856 0.583333333333333 5.3 5 3 increased fibrosarcoma incidence 0.195637205416663 0.415076319463109 0.805855855855856 0.583333333333333 5.3 5 3 abnormal respiratory motile cilium morphology 0.195637205416663 0.415076319463109 0.805855855855856 0.583333333333333 5.3 5 3 small ovary 0.0012823761205475 0.0104587232782358 0.804590776019347 0.582417582417582 5.3 5 3 abnormal B cell differentiation 0.0012823761205475 0.0104587232782358 0.804590776019347 0.582417582417582 5.3 5 3 abnormal rostral-caudal axis patterning 0.0112397938714878 0.0607068925997698 0.803762723762724 0.581818181818182 5.3 5 3 hypoglycemia 0.00127840141857372 0.0104587232782358 0.802142234400299 0.580645161290323 5.3 5 3 absent mature ovarian follicles 0.0522538754168873 0.183719455971035 0.802142234400299 0.580645161290323 5.3 5 3 increased body length 0.0162792040359292 0.0788648985126335 0.801250965250965 0.58 5.3 5 3 hyperkeratosis 0.00536353566614335 0.034155233340243 0.800850539980975 0.579710144927536 5.3 5 3 irregular coat pigmentation 0.121034064134204 0.325384603867126 0.799796789270473 0.578947368421053 5.3 5 3 unresponsive to tactile stimuli 0.121034064134204 0.325384603867126 0.799796789270473 0.578947368421053 5.3 5 3 delayed sexual maturation 0.121034064134204 0.325384603867126 0.799796789270473 0.578947368421053 5.3 5 3 decreased tumor incidence 0.121034064134204 0.325384603867126 0.799796789270473 0.578947368421053 5.3 5 3 abnormal metatarsal bone morphology 0.121034064134204 0.325384603867126 0.799796789270473 0.578947368421053 5.3 5 3 increased left ventricle weight 0.121034064134204 0.325384603867126 0.799796789270473 0.578947368421053 5.3 5 3 absent amnion 0.121034064134204 0.325384603867126 0.799796789270473 0.578947368421053 5.3 5 3 decreased eye pigmentation 0.121034064134204 0.325384603867126 0.799796789270473 0.578947368421053 5.3 5 3 decreased liver regeneration 0.121034064134204 0.325384603867126 0.799796789270473 0.578947368421053 5.3 5 3 increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 0.121034064134204 0.325384603867126 0.799796789270473 0.578947368421053 5.3 5 3 decreased susceptibility to weight gain 0.121034064134204 0.325384603867126 0.799796789270473 0.578947368421053 5.3 5 3 altered response to myocardial infarction 0.0236693477873103 0.106670702504151 0.798181038181038 0.577777777777778 5.3 5 3 abnormal metabolism 0.0236693477873103 0.106670702504151 0.798181038181038 0.577777777777778 5.3 5 3 increased percent body fat/body weight 0.0161448301987204 0.0785146923153805 0.797000297000297 0.576923076923077 5.3 5 3 increased leukemia incidence 0.0781029478583292 0.234782609396102 0.797000297000297 0.576923076923077 5.3 5 3 abnormal ocular fundus morphology 0.0781029478583292 0.234782609396102 0.797000297000297 0.576923076923077 5.3 5 3 pulmonary edema 0.0781029478583292 0.234782609396102 0.797000297000297 0.576923076923077 5.3 5 3 abnormal tooth development 0.0515817717660843 0.181876378392894 0.795390195390195 0.575757575757576 5.3 5 3 abnormal middle ear ossicle morphology 0.0515817717660843 0.181876378392894 0.795390195390195 0.575757575757576 5.3 5 3 decreased sensitivity to xenobiotic induced morbidity/mortality 0.0515817717660843 0.181876378392894 0.795390195390195 0.575757575757576 5.3 5 3 myeloid hyperplasia 0.0515817717660843 0.181876378392894 0.795390195390195 0.575757575757576 5.3 5 3 increased susceptibility to weight loss 0.0345762197590395 0.133553333308402 0.794343629343629 0.575 5.3 5 3 abnormal seminal vesicle morphology 0.0158036164584845 0.0770558419636143 0.789409817981247 0.571428571428571 5.3 5 3 abnormal muscle morphology 0.0341130487015105 0.132691491235352 0.789409817981247 0.571428571428571 5.3 5 3 abnormal spleen white pulp morphology 0.0341130487015105 0.132691491235352 0.789409817981247 0.571428571428571 5.3 5 3 abnormal circulating cholesterol level 0.0767194994658628 0.231742264628213 0.789409817981247 0.571428571428571 5.3 5 3 increased circulating luteinizing hormone level 0.0767194994658628 0.231742264628213 0.789409817981247 0.571428571428571 5.3 5 3 abnormal salivary gland morphology 0.118337071263897 0.320482814119699 0.789409817981247 0.571428571428571 5.3 5 3 abnormal hematopoietic system physiology 0.118337071263897 0.320482814119699 0.789409817981247 0.571428571428571 5.3 5 3 increased acute inflammation 0.118337071263897 0.320482814119699 0.789409817981247 0.571428571428571 5.3 5 3 increased keratinocyte proliferation 0.118337071263897 0.320482814119699 0.789409817981247 0.571428571428571 5.3 5 3 abnormal zigzag hair morphology 0.189364127684384 0.415076319463109 0.789409817981247 0.571428571428571 5.3 5 3 abnormal spleen periarteriolar lymphoid sheath morphology 0.189364127684384 0.415076319463109 0.789409817981247 0.571428571428571 5.3 5 3 decreased coping response 0.189364127684384 0.415076319463109 0.789409817981247 0.571428571428571 5.3 5 3 abnormal prepulse inhibition 0.189364127684384 0.415076319463109 0.789409817981247 0.571428571428571 5.3 5 3 abnormal imprinting 0.189364127684384 0.415076319463109 0.789409817981247 0.571428571428571 5.3 5 3 abnormal sagittal suture morphology 0.189364127684384 0.415076319463109 0.789409817981247 0.571428571428571 5.3 5 3 abnormal positive T cell selection 0.189364127684384 0.415076319463109 0.789409817981247 0.571428571428571 5.3 5 3 decreased cornea thickness 0.189364127684384 0.415076319463109 0.789409817981247 0.571428571428571 5.3 5 3 increased circulating serum albumin level 0.0508034456340998 0.180766447133286 0.789409817981247 0.571428571428571 5.3 5 3 abnormal lens morphology 0.000421311305925067 0.00421735160357587 0.787868001930502 0.5703125 5.3 5 3 decreased B cell proliferation 0.00513702888069806 0.0334959887457603 0.786911685645863 0.569620253164557 5.3 5 3 abnormal heart left ventricle morphology 0.00741069623534901 0.044206491331968 0.786668811668812 0.569444444444444 5.3 5 3 decreased monocyte cell number 0.0107295610871904 0.0589829463080358 0.786373626373626 0.569230769230769 5.3 5 3 cochlear hair cell degeneration 0.0336004390842982 0.131004846743247 0.784924534924535 0.568181818181818 5.3 5 3 abnormal amino acid level 0.0336004390842982 0.131004846743247 0.784924534924535 0.568181818181818 5.3 5 3 decreased sensitivity to induced morbidity/mortality 0.0336004390842982 0.131004846743247 0.784924534924535 0.568181818181818 5.3 5 3 decreased T cell proliferation 0.00020291360471238 0.00228392575439839 0.784075967859752 0.567567567567568 5.3 5 3 abnormal branching of the mammary ductal tree 0.0499428646352314 0.180766447133286 0.784075967859752 0.567567567567568 5.3 5 3 increased insulin secretion 0.0499428646352314 0.180766447133286 0.784075967859752 0.567567567567568 5.3 5 3 abnormal hair follicle development 0.0499428646352314 0.180766447133286 0.784075967859752 0.567567567567568 5.3 5 3 maternal effect 0.0105906656974169 0.0586732314528384 0.78351869993661 0.567164179104478 5.3 5 3 abnormal spleen marginal zone morphology 0.0751992259342142 0.229505818754808 0.782831402831403 0.566666666666667 5.3 5 3 abnormal microglial cell physiology 0.0751992259342142 0.229505818754808 0.782831402831403 0.566666666666667 5.3 5 3 abnormal placenta development 0.0224759115744834 0.101930410285374 0.781962555547461 0.566037735849057 5.3 5 3 abnormal retinal cone cell morphology 0.11542639339624 0.317163421179005 0.780829276481451 0.565217391304348 5.3 5 3 abnormal cardiovascular development 0.11542639339624 0.317163421179005 0.780829276481451 0.565217391304348 5.3 5 3 abnormal hepatocyte physiology 0.11542639339624 0.317163421179005 0.780829276481451 0.565217391304348 5.3 5 3 increased lymphocyte cell number 0.0104432445636587 0.05798564922344 0.78082927648145 0.565217391304348 5.3 5 3 abnormal food intake 0.0104432445636587 0.05798564922344 0.78082927648145 0.565217391304348 5.3 5 3 increased urine protein level 0.00712270008319632 0.042590664559978 0.779289179289179 0.564102564102564 5.3 5 3 small lens 0.04901937062187 0.180111793828511 0.779289179289179 0.564102564102564 5.3 5 3 abnormal iris morphology 0.04901937062187 0.180111793828511 0.779289179289179 0.564102564102564 5.3 5 3 impaired macrophage chemotaxis 0.04901937062187 0.180111793828511 0.779289179289179 0.564102564102564 5.3 5 3 abnormal response to injury 0.04901937062187 0.180111793828511 0.779289179289179 0.564102564102564 5.3 5 3 abnormal CD4-positive, alpha-beta T cell physiology 0.0102885861133282 0.0572831525673501 0.778291369840666 0.563380281690141 5.3 5 3 abnormal tooth morphology 0.0149191948106183 0.0732704779692263 0.77707528957529 0.5625 5.3 5 3 abnormal lymphatic vessel morphology 0.073582468050799 0.226648503521988 0.77707528957529 0.5625 5.3 5 3 increased fatty acid level 0.073582468050799 0.226648503521988 0.77707528957529 0.5625 5.3 5 3 abnormal tympanic ring morphology 0.182928256905341 0.41329158860312 0.77707528957529 0.5625 5.3 5 3 absent mandible 0.182928256905341 0.41329158860312 0.77707528957529 0.5625 5.3 5 3 abnormal extraembryonic endoderm formation 0.182928256905341 0.41329158860312 0.77707528957529 0.5625 5.3 5 3 white spotting 0.182928256905341 0.41329158860312 0.77707528957529 0.5625 5.3 5 3 paternal imprinting 0.182928256905341 0.41329158860312 0.77707528957529 0.5625 5.3 5 3 decreased cochlear coiling 0.182928256905341 0.41329158860312 0.77707528957529 0.5625 5.3 5 3 large intestinal inflammation 0.182928256905341 0.41329158860312 0.77707528957529 0.5625 5.3 5 3 abnormal molar crown morphology 0.182928256905341 0.41329158860312 0.77707528957529 0.5625 5.3 5 3 small epididymis 0.182928256905341 0.41329158860312 0.77707528957529 0.5625 5.3 5 3 abnormal epididymis epithelium morphology 0.182928256905341 0.41329158860312 0.77707528957529 0.5625 5.3 5 3 increased thymus weight 0.182928256905341 0.41329158860312 0.77707528957529 0.5625 5.3 5 3 decreased circulating prolactin level 0.182928256905341 0.41329158860312 0.77707528957529 0.5625 5.3 5 3 blepharitis 0.182928256905341 0.41329158860312 0.77707528957529 0.5625 5.3 5 3 abnormal thoracic cage shape 0.182928256905341 0.41329158860312 0.77707528957529 0.5625 5.3 5 3 dilated respiratory conducting tubes 0.182928256905341 0.41329158860312 0.77707528957529 0.5625 5.3 5 3 decreased adipocyte glucose uptake 0.182928256905341 0.41329158860312 0.77707528957529 0.5625 5.3 5 3 cataract 0.00111893474216428 0.00935579889456691 0.776361721816267 0.56198347107438 5.3 5 3 abnormal circulating protein level 0.0318563747690614 0.128954812429683 0.773621621621622 0.56 5.3 5 3 decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 0.112390656566187 0.312196268239408 0.773621621621622 0.56 5.3 5 3 abnormal spleen red pulp morphology 0.0719001038688198 0.226648503521988 0.771996366114013 0.558823529411765 5.3 5 3 decreased pancreatic beta cell number 0.0719001038688198 0.226648503521988 0.771996366114013 0.558823529411765 5.3 5 3 polyuria 0.00979215907133923 0.0549221999773537 0.7714686857544 0.558441558441558 5.3 5 3 decreased body temperature 0.0312296915070941 0.126520940755532 0.77043362043362 0.557692307692308 5.3 5 3 abnormal male meiosis 0.0209438461677483 0.0965985834422485 0.769998101145642 0.557377049180328 5.3 5 3 increased liver weight 0.00656818933917725 0.0398011473354529 0.769226044226044 0.556818181818182 5.3 5 3 skin lesions 0.0205347339594458 0.0951213235086061 0.767481767481767 0.555555555555556 5.3 5 3 abnormal trigeminal ganglion morphology 0.109291262675721 0.304096214659795 0.767481767481767 0.555555555555556 5.3 5 3 abnormal type II pneumocyte morphology 0.109291262675721 0.304096214659795 0.767481767481767 0.555555555555556 5.3 5 3 abnormal retinal rod cell morphology 0.176509138564066 0.40207553313014 0.767481767481767 0.555555555555556 5.3 5 3 decreased heart rate variability 0.176509138564066 0.40207553313014 0.767481767481767 0.555555555555556 5.3 5 3 abnormal eye anterior chamber morphology 0.176509138564066 0.40207553313014 0.767481767481767 0.555555555555556 5.3 5 3 decreased fluid intake 0.176509138564066 0.40207553313014 0.767481767481767 0.555555555555556 5.3 5 3 distorted hair follicle pattern 0.30946970850923 0.591703228221914 0.767481767481767 0.555555555555556 5.3 5 3 synostosis 0.30946970850923 0.591703228221914 0.767481767481767 0.555555555555556 5.3 5 3 absent parathyroid glands 0.30946970850923 0.591703228221914 0.767481767481767 0.555555555555556 5.3 5 3 abnormal sympathetic neuron morphology 0.30946970850923 0.591703228221914 0.767481767481767 0.555555555555556 5.3 5 3 abnormal geniculate ganglion morphology 0.30946970850923 0.591703228221914 0.767481767481767 0.555555555555556 5.3 5 3 abnormal vagina epithelium morphology 0.30946970850923 0.591703228221914 0.767481767481767 0.555555555555556 5.3 5 3 psoriasis 0.30946970850923 0.591703228221914 0.767481767481767 0.555555555555556 5.3 5 3 abnormal lens vesicle development 0.30946970850923 0.591703228221914 0.767481767481767 0.555555555555556 5.3 5 3 decreased level of surface class I molecules 0.30946970850923 0.591703228221914 0.767481767481767 0.555555555555556 5.3 5 3 abnormal lung volume 0.30946970850923 0.591703228221914 0.767481767481767 0.555555555555556 5.3 5 3 abnormal vomeronasal organ morphology 0.30946970850923 0.591703228221914 0.767481767481767 0.555555555555556 5.3 5 3 genetic imprinting 0.30946970850923 0.591703228221914 0.767481767481767 0.555555555555556 5.3 5 3 premature neuronal precursor differentiation 0.30946970850923 0.591703228221914 0.767481767481767 0.555555555555556 5.3 5 3 decreased susceptibility to induced choroidal neovascularization 0.30946970850923 0.591703228221914 0.767481767481767 0.555555555555556 5.3 5 3 abnormal ovary physiology 0.30946970850923 0.591703228221914 0.767481767481767 0.555555555555556 5.3 5 3 impaired febrile response 0.30946970850923 0.591703228221914 0.767481767481767 0.555555555555556 5.3 5 3 decreased muscle weight 0.30946970850923 0.591703228221914 0.767481767481767 0.555555555555556 5.3 5 3 abnormal bony labyrinth 0.30946970850923 0.591703228221914 0.767481767481767 0.555555555555556 5.3 5 3 abnormal proprioceptive neuron morphology 0.30946970850923 0.591703228221914 0.767481767481767 0.555555555555556 5.3 5 3 abnormal hair cell mechanoelectric transduction 0.30946970850923 0.591703228221914 0.767481767481767 0.555555555555556 5.3 5 3 liver hyperplasia 0.30946970850923 0.591703228221914 0.767481767481767 0.555555555555556 5.3 5 3 increased tidal volume 0.30946970850923 0.591703228221914 0.767481767481767 0.555555555555556 5.3 5 3 abnormal hyoid bone lesser horn morphology 0.30946970850923 0.591703228221914 0.767481767481767 0.555555555555556 5.3 5 3 axonal spheroids 0.30946970850923 0.591703228221914 0.767481767481767 0.555555555555556 5.3 5 3 prolonged RR interval 0.30946970850923 0.591703228221914 0.767481767481767 0.555555555555556 5.3 5 3 iris coloboma 0.30946970850923 0.591703228221914 0.767481767481767 0.555555555555556 5.3 5 3 decreased susceptibility to parasitic infection induced morbidity/mortality 0.30946970850923 0.591703228221914 0.767481767481767 0.555555555555556 5.3 5 3 abnormal pulmonary alveolar system morphology 0.30946970850923 0.591703228221914 0.767481767481767 0.555555555555556 5.3 5 3 decreased airway resistance 0.30946970850923 0.591703228221914 0.767481767481767 0.555555555555556 5.3 5 3 increased core body temperature 0.30946970850923 0.591703228221914 0.767481767481767 0.555555555555556 5.3 5 3 decreased bone trabecular spacing 0.30946970850923 0.591703228221914 0.767481767481767 0.555555555555556 5.3 5 3 decreased fatty acid oxidation 0.30946970850923 0.591703228221914 0.767481767481767 0.555555555555556 5.3 5 3 decreased bone mineral density of femur 0.30946970850923 0.591703228221914 0.767481767481767 0.555555555555556 5.3 5 3 increased granulocyte number 0.0136164146451257 0.0681505662570425 0.76540749243452 0.554054054054054 5.3 5 3 increased systemic arterial blood pressure 0.0449696688562738 0.167709222308817 0.764215887620143 0.553191489361702 5.3 5 3 abnormal microglial cell morphology 0.106171337062621 0.295746025692351 0.762188789774997 0.551724137931034 5.3 5 3 decreased retinal photoreceptor cell number 0.106171337062621 0.295746025692351 0.762188789774997 0.551724137931034 5.3 5 3 decreased bone strength 0.106171337062621 0.295746025692351 0.762188789774997 0.551724137931034 5.3 5 3 abnormal dendritic cell physiology 0.0041039642038273 0.0278923796639902 0.761743586042651 0.551401869158878 5.3 5 3 abnormal respiratory system physiology 0.0439165976735954 0.165896031454926 0.761216610196202 0.551020408163265 5.3 5 3 impaired ovarian folliculogenesis 0.0666721105653293 0.224572613447876 0.75980694980695 0.55 5.3 5 3 abnormal cell proliferation 0.170204347133016 0.40207553313014 0.75980694980695 0.55 5.3 5 3 abnormal hair texture 0.170204347133016 0.40207553313014 0.75980694980695 0.55 5.3 5 3 abnormal fibula morphology 0.170204347133016 0.40207553313014 0.75980694980695 0.55 5.3 5 3 decreased circulating VLDL cholesterol level 0.170204347133016 0.40207553313014 0.75980694980695 0.55 5.3 5 3 enhanced behavioral response to xenobiotic 0.170204347133016 0.40207553313014 0.75980694980695 0.55 5.3 5 3 abnormal CD8-positive, alpha beta T cell morphology 0.103061437276683 0.287990782697714 0.757578776933616 0.548387096774194 5.3 5 3 abnormal intestine physiology 0.103061437276683 0.287990782697714 0.757578776933616 0.548387096774194 5.3 5 3 increased food intake 0.0122532230877492 0.0631053673515032 0.756517742232028 0.547619047619048 5.3 5 3 decreased neutrophil cell number 0.00370704686484334 0.0255791375209371 0.755674355674356 0.547008547008547 5.3 5 3 spleen hyperplasia 0.0180231353658691 0.0848297998535468 0.755202059202059 0.546666666666667 5.3 5 3 abnormal joint morphology 0.0407594448510004 0.154203983371656 0.753527553527554 0.545454545454545 5.3 5 3 increased T cell number 0.0117138614969006 0.061022472195896 0.753527553527554 0.545454545454545 5.3 5 3 osteoporosis 0.0631751325958266 0.213285020900047 0.753527553527554 0.545454545454545 5.3 5 3 abnormal gametogenesis 0.0631751325958266 0.213285020900047 0.753527553527554 0.545454545454545 5.3 5 3 abnormal epidermis stratum basale morphology 0.0999833035924567 0.287990782697714 0.753527553527554 0.545454545454545 5.3 5 3 diarrhea 0.0999833035924567 0.287990782697714 0.753527553527554 0.545454545454545 5.3 5 3 abnormal basisphenoid bone morphology 0.164067109606056 0.40207553313014 0.753527553527554 0.545454545454545 5.3 5 3 abnormal facial nerve morphology 0.164067109606056 0.40207553313014 0.753527553527554 0.545454545454545 5.3 5 3 parakeratosis 0.164067109606056 0.40207553313014 0.753527553527554 0.545454545454545 5.3 5 3 prolonged PR interval 0.164067109606056 0.40207553313014 0.753527553527554 0.545454545454545 5.3 5 3 abnormal circulating lipid level 0.164067109606056 0.40207553313014 0.753527553527554 0.545454545454545 5.3 5 3 abnormal sperm midpiece morphology 0.164067109606056 0.40207553313014 0.753527553527554 0.545454545454545 5.3 5 3 abnormal ear position 0.292154866056642 0.56731868018415 0.753527553527554 0.545454545454545 5.3 5 3 abnormal thrombopoiesis 0.292154866056642 0.56731868018415 0.753527553527554 0.545454545454545 5.3 5 3 abnormal awl hair morphology 0.292154866056642 0.56731868018415 0.753527553527554 0.545454545454545 5.3 5 3 abnormal stomach epithelium morphology 0.292154866056642 0.56731868018415 0.753527553527554 0.545454545454545 5.3 5 3 abnormal large intestine morphology 0.292154866056642 0.56731868018415 0.753527553527554 0.545454545454545 5.3 5 3 delayed hepatic development 0.292154866056642 0.56731868018415 0.753527553527554 0.545454545454545 5.3 5 3 abnormal food preference 0.292154866056642 0.56731868018415 0.753527553527554 0.545454545454545 5.3 5 3 abnormal vestibular ganglion morphology 0.292154866056642 0.56731868018415 0.753527553527554 0.545454545454545 5.3 5 3 retinal detachment 0.292154866056642 0.56731868018415 0.753527553527554 0.545454545454545 5.3 5 3 abnormal frequency of paradoxical sleep 0.292154866056642 0.56731868018415 0.753527553527554 0.545454545454545 5.3 5 3 abnormal lymph circulation 0.292154866056642 0.56731868018415 0.753527553527554 0.545454545454545 5.3 5 3 dilated renal glomerular capsule 0.292154866056642 0.56731868018415 0.753527553527554 0.545454545454545 5.3 5 3 pathological neovascularization 0.292154866056642 0.56731868018415 0.753527553527554 0.545454545454545 5.3 5 3 abnormal pituitary gland development 0.292154866056642 0.56731868018415 0.753527553527554 0.545454545454545 5.3 5 3 increased glycogen level 0.292154866056642 0.56731868018415 0.753527553527554 0.545454545454545 5.3 5 3 abnormal superovulation 0.292154866056642 0.56731868018415 0.753527553527554 0.545454545454545 5.3 5 3 decreased palatine bone horizontal plate size 0.292154866056642 0.56731868018415 0.753527553527554 0.545454545454545 5.3 5 3 aberrant origin of the right subclavian artery 0.292154866056642 0.56731868018415 0.753527553527554 0.545454545454545 5.3 5 3 abnormal phrenic nerve innervation pattern to diaphragm 0.292154866056642 0.56731868018415 0.753527553527554 0.545454545454545 5.3 5 3 chylous ascites 0.292154866056642 0.56731868018415 0.753527553527554 0.545454545454545 5.3 5 3 hypolactation 0.292154866056642 0.56731868018415 0.753527553527554 0.545454545454545 5.3 5 3 abnormal inner ear morphology 0.0614501708580208 0.212301805568509 0.750797381232164 0.543478260869565 5.3 5 3 impaired fertilization 0.0253730554441397 0.109250180225919 0.749939327082184 0.542857142857143 5.3 5 3 decreased bone mineralization 0.0969523855225489 0.281082819332565 0.749939327082184 0.542857142857143 5.3 5 3 abnormal urine homeostasis 0.0106662370108384 0.0587965415808513 0.748294723294723 0.541666666666667 5.3 5 3 abnormal lymph node morphology 0.0597485060773539 0.206566238870629 0.748294723294723 0.541666666666667 5.3 5 3 curly vibrissae 0.158125525944567 0.40207553313014 0.748294723294723 0.541666666666667 5.3 5 3 abnormal primitive streak formation 0.158125525944567 0.40207553313014 0.748294723294723 0.541666666666667 5.3 5 3 abnormal inner cell mass apoptosis 0.158125525944567 0.40207553313014 0.748294723294723 0.541666666666667 5.3 5 3 increased brown adipose tissue amount 0.0939795810224303 0.272622982849324 0.746739017009287 0.540540540540541 5.3 5 3 skin inflammation 0.0939795810224303 0.272622982849324 0.746739017009287 0.540540540540541 5.3 5 3 testicular atrophy 0.0580742506484826 0.20105733957982 0.745992277992278 0.54 5.3 5 3 cachexia 0.00967484014009899 0.0543254285519102 0.743866943866944 0.538461538461538 5.3 5 3 abnormal skin condition 0.0564305454801674 0.195502760281221 0.743866943866944 0.538461538461538 5.3 5 3 abnormal hair growth 0.0564305454801674 0.195502760281221 0.743866943866944 0.538461538461538 5.3 5 3 increased vascular permeability 0.0910724564615866 0.264498231696669 0.743866943866944 0.538461538461538 5.3 5 3 small seminal vesicle 0.152392983392021 0.388996968894461 0.743866943866944 0.538461538461538 5.3 5 3 decreased Peyer's patch number 0.152392983392021 0.388996968894461 0.743866943866944 0.538461538461538 5.3 5 3 increased foot pad pigmentation 0.276689043695305 0.54279494967829 0.743866943866944 0.538461538461538 5.3 5 3 uterus hypoplasia 0.276689043695305 0.54279494967829 0.743866943866944 0.538461538461538 5.3 5 3 abnormal grip strength 0.276689043695305 0.54279494967829 0.743866943866944 0.538461538461538 5.3 5 3 increased circulating adrenocorticotropin level 0.276689043695305 0.54279494967829 0.743866943866944 0.538461538461538 5.3 5 3 abnormal intercostal muscle morphology 0.276689043695305 0.54279494967829 0.743866943866944 0.538461538461538 5.3 5 3 abnormal dopaminergic neuron morphology 0.276689043695305 0.54279494967829 0.743866943866944 0.538461538461538 5.3 5 3 decreased alcohol consumption 0.276689043695305 0.54279494967829 0.743866943866944 0.538461538461538 5.3 5 3 abnormal vestibulocochlear ganglion morphology 0.276689043695305 0.54279494967829 0.743866943866944 0.538461538461538 5.3 5 3 abnormal exocrine pancreas morphology 0.276689043695305 0.54279494967829 0.743866943866944 0.538461538461538 5.3 5 3 abnormal trabecular bone morphology 0.00619347354335229 0.0377604545075706 0.742973946335291 0.53781512605042 5.3 5 3 arrested B cell differentiation 0.0882361165565664 0.256410443848667 0.74127507298239 0.536585365853659 5.3 5 3 abnormal epidermal layer morphology 0.0337961612610511 0.13166476293949 0.740786749482402 0.536231884057971 5.3 5 3 reddish skin 0.146874066379404 0.375487399916515 0.740071704357419 0.535714285714286 5.3 5 3 straub tail 0.146874066379404 0.375487399916515 0.740071704357419 0.535714285714286 5.3 5 3 abnormal retinal inner nuclear layer morphology 0.146874066379404 0.375487399916515 0.740071704357419 0.535714285714286 5.3 5 3 decreased circulating progesterone level 0.146874066379404 0.375487399916515 0.740071704357419 0.535714285714286 5.3 5 3 abnormal renal tubule epithelium morphology 0.146874066379404 0.375487399916515 0.740071704357419 0.535714285714286 5.3 5 3 abnormal T cell differentiation 0.0130352835542346 0.0653798545587955 0.738606215833939 0.534653465346535 5.3 5 3 liver inflammation 0.0078947232270384 0.0460448394542978 0.736782496782497 0.533333333333333 5.3 5 3 abnormal hair cycle 0.141568035495085 0.363228971938138 0.736782496782497 0.533333333333333 5.3 5 3 gastrointestinal hemorrhage 0.141568035495085 0.363228971938138 0.736782496782497 0.533333333333333 5.3 5 3 liver hemorrhage 0.141568035495085 0.363228971938138 0.736782496782497 0.533333333333333 5.3 5 3 abnormal fat pad morphology 0.141568035495085 0.363228971938138 0.736782496782497 0.533333333333333 5.3 5 3 vagina atresia 0.26269542548229 0.517588016544313 0.736782496782497 0.533333333333333 5.3 5 3 abnormal epidermis stratum spinosum morphology 0.26269542548229 0.517588016544313 0.736782496782497 0.533333333333333 5.3 5 3 placental labyrinth hypoplasia 0.26269542548229 0.517588016544313 0.736782496782497 0.533333333333333 5.3 5 3 abnormal bronchus morphology 0.26269542548229 0.517588016544313 0.736782496782497 0.533333333333333 5.3 5 3 greasy coat 0.26269542548229 0.517588016544313 0.736782496782497 0.533333333333333 5.3 5 3 abnormal zygomatic bone morphology 0.26269542548229 0.517588016544313 0.736782496782497 0.533333333333333 5.3 5 3 abnormal neurotransmitter secretion 0.26269542548229 0.517588016544313 0.736782496782497 0.533333333333333 5.3 5 3 abnormal coronary vessel morphology 0.26269542548229 0.517588016544313 0.736782496782497 0.533333333333333 5.3 5 3 abnormal microglial cell activation 0.26269542548229 0.517588016544313 0.736782496782497 0.533333333333333 5.3 5 3 decreased eosinophil cell number 0.0473041961261967 0.176179855902192 0.73390444015444 0.53125 5.3 5 3 thin skin 0.131576903281549 0.338292038152821 0.731364978423802 0.529411764705882 5.3 5 3 abnormal bone remodeling 0.131576903281549 0.338292038152821 0.731364978423802 0.529411764705882 5.3 5 3 decreased regulatory T cell number 0.131576903281549 0.338292038152821 0.731364978423802 0.529411764705882 5.3 5 3 abnormal circulating chemokine level 0.249912165070377 0.494162568054502 0.731364978423802 0.529411764705882 5.3 5 3 increased hepatoma incidence 0.249912165070377 0.494162568054502 0.731364978423802 0.529411764705882 5.3 5 3 delayed heart development 0.249912165070377 0.494162568054502 0.731364978423802 0.529411764705882 5.3 5 3 dehydration 0.0432402496012243 0.16346522930554 0.730204081632653 0.528571428571429 5.3 5 3 head tilt 0.126878989323375 0.327058534654814 0.729107679107679 0.527777777777778 5.3 5 3 decreased grooming behavior 0.238148110152802 0.472214766046309 0.727087990245885 0.526315789473684 5.3 5 3 abnormal ear morphology 0.238148110152802 0.472214766046309 0.727087990245885 0.526315789473684 5.3 5 3 decreased germ cell number 0.238148110152802 0.472214766046309 0.727087990245885 0.526315789473684 5.3 5 3 abnormal neural crest cell migration 0.238148110152802 0.472214766046309 0.727087990245885 0.526315789473684 5.3 5 3 oliguria 0.238148110152802 0.472214766046309 0.727087990245885 0.526315789473684 5.3 5 3 increased circulating VLDL cholesterol level 0.238148110152802 0.472214766046309 0.727087990245885 0.526315789473684 5.3 5 3 abnormal pancreatic beta cell morphology 0.118041259820607 0.320379305841528 0.72527027027027 0.525 5.3 5 3 abnormal clavicle morphology 0.227258350589048 0.452063292355264 0.723625666482809 0.523809523809524 5.3 5 3 increased bone ossification 0.227258350589048 0.452063292355264 0.723625666482809 0.523809523809524 5.3 5 3 increased T cell proliferation 0.0196050578417882 0.0911543577223329 0.723010861328618 0.523364485981308 5.3 5 3 abnormal femur morphology 0.0581323029487043 0.201118363817666 0.721661960467931 0.522388059701492 5.3 5 3 bidirectional circling 0.217129709107673 0.432607249824058 0.720765485982877 0.521739130434783 5.3 5 3 increased susceptibility to age related obesity 0.217129709107673 0.432607249824058 0.720765485982877 0.521739130434783 5.3 5 3 abnormal intestinal epithelium morphology 0.102384000959727 0.287990782697714 0.719514157014157 0.520833333333333 5.3 5 3 increased pre-B cell number 0.207671634437811 0.415076319463109 0.718362934362934 0.52 5.3 5 3 abnormal CD8-positive, alpha-beta T cell physiology 0.190484133504531 0.415076319463109 0.714551990414059 0.517241379310345 5.3 5 3 increased eosinophil cell number 0.080312526688277 0.235335824624943 0.713015319466932 0.516129032258065 5.3 5 3 abnormal nose morphology 0.182641740261381 0.41329158860312 0.713015319466932 0.516129032258065 5.3 5 3 abnormal aorta morphology 0.175239044881677 0.40207553313014 0.711664911664912 0.515151515151515 5.3 5 3 decreased systemic arterial blood pressure 0.175239044881677 0.40207553313014 0.711664911664912 0.515151515151515 5.3 5 3 thick epidermis 0.0701239959574552 0.226648503521988 0.710468836183122 0.514285714285714 5.3 5 3 abnormal long bone metaphysis morphology 0.161606142529928 0.40207553313014 0.709402066158823 0.513513513513513 5.3 5 3 decreased circulating chloride level 0.161606142529928 0.40207553313014 0.709402066158823 0.513513513513513 5.3 5 3 increased B cell number 0.0264259041119536 0.113530978373894 0.708444708444708 0.512820512820513 5.3 5 3 impaired macrophage phagocytosis 0.143651074188224 0.368383553652791 0.706797162611116 0.511627906976744 5.3 5 3 abnormal epidermis stratum corneum morphology 0.128153329030237 0.330001455447944 0.704830194626113 0.510204081632653 5.3 5 3 decreased urine osmolality 0.128153329030237 0.330001455447944 0.704830194626113 0.510204081632653 5.3 5 3 increased macrophage cell number 0.110552188550827 0.307432721095788 0.702851723904355 0.508771929824561 5.3 5 3 abnormal lymphocyte physiology 0.170409687511406 0.40207553313014 0.690733590733591 0.5 5.3 5 3 increased dopamine level 0.228812544790077 0.454972985743658 0.690733590733591 0.5 5.3 5 3 abnormal level of surface class II molecules 0.342462594059239 0.59196608497537 0.690733590733591 0.5 5.3 5 3 increased circulating estradiol level 0.342462594059239 0.59196608497537 0.690733590733591 0.5 5.3 5 3 decreased circulating triiodothyronine level 0.342462594059239 0.59196608497537 0.690733590733591 0.5 5.3 5 3 increased heart left ventricle size 0.342462594059239 0.59196608497537 0.690733590733591 0.5 5.3 5 3 decreased susceptibility to injury 0.112335755376796 0.312196268239408 0.690733590733591 0.5 5.3 5 3 abnormal small intestine morphology 0.145737843353811 0.373542385721387 0.690733590733591 0.5 5.3 5 3 abnormal kidney physiology 0.163769399856892 0.40207553313014 0.690733590733591 0.5 5.3 5 3 abnormal myelopoiesis 0.177405927748548 0.403933405285596 0.690733590733591 0.5 5.3 5 3 abnormal systemic arterial blood pressure 0.209597325435252 0.418269833148968 0.690733590733591 0.5 5.3 5 3 abnormal epidermis stratum granulosum morphology 0.209597325435252 0.418269833148968 0.690733590733591 0.5 5.3 5 3 abnormal retinal photoreceptor morphology 0.218901186481804 0.435787676169258 0.690733590733591 0.5 5.3 5 3 decreased cytotoxic T cell cytolysis 0.218901186481804 0.435787676169258 0.690733590733591 0.5 5.3 5 3 increased metastatic potential 0.239400231513977 0.474319455110328 0.690733590733591 0.5 5.3 5 3 abnormal lactation 0.239400231513977 0.474319455110328 0.690733590733591 0.5 5.3 5 3 abnormal cellular extravasation 0.276133892270779 0.54279494967829 0.690733590733591 0.5 5.3 5 3 intestinal ulcer 0.290449591572041 0.56731868018415 0.690733590733591 0.5 5.3 5 3 abnormal lysosome physiology 0.290449591572041 0.56731868018415 0.690733590733591 0.5 5.3 5 3 abnormal stomach glandular epithelium morphology 0.323315191576688 0.59196608497537 0.690733590733591 0.5 5.3 5 3 abnormal rectum morphology 0.38867252669662 0.59196608497537 0.690733590733591 0.5 5.3 5 3 amyloidosis 0.38867252669662 0.59196608497537 0.690733590733591 0.5 5.3 5 3 thick dermal layer 0.323315191576688 0.59196608497537 0.690733590733591 0.5 5.3 5 3 irregularly shaped pupil 0.364013959706227 0.59196608497537 0.690733590733591 0.5 5.3 5 3 absent optic nerve 0.38867252669662 0.59196608497537 0.690733590733591 0.5 5.3 5 3 abnormal pilomotor reflex 0.38867252669662 0.59196608497537 0.690733590733591 0.5 5.3 5 3 abnormal thymus involution 0.38867252669662 0.59196608497537 0.690733590733591 0.5 5.3 5 3 eye inflammation 0.323315191576688 0.59196608497537 0.690733590733591 0.5 5.3 5 3 myocarditis 0.38867252669662 0.59196608497537 0.690733590733591 0.5 5.3 5 3 interstitial pneumonia 0.38867252669662 0.59196608497537 0.690733590733591 0.5 5.3 5 3 increased circulating parathyroid hormone level 0.38867252669662 0.59196608497537 0.690733590733591 0.5 5.3 5 3 absent otoliths 0.364013959706227 0.59196608497537 0.690733590733591 0.5 5.3 5 3 abnormal kidney medulla morphology 0.364013959706227 0.59196608497537 0.690733590733591 0.5 5.3 5 3 abnormal gastrocnemius morphology 0.38867252669662 0.59196608497537 0.690733590733591 0.5 5.3 5 3 absent tail 0.38867252669662 0.59196608497537 0.690733590733591 0.5 5.3 5 3 decreased circulating ketone body level 0.38867252669662 0.59196608497537 0.690733590733591 0.5 5.3 5 3 increased fear-related response 0.38867252669662 0.59196608497537 0.690733590733591 0.5 5.3 5 3 decreased activity of thyroid 0.323315191576688 0.59196608497537 0.690733590733591 0.5 5.3 5 3 abnormal nucleotide metabolism 0.38867252669662 0.59196608497537 0.690733590733591 0.5 5.3 5 3 enlarged stomach 0.364013959706227 0.59196608497537 0.690733590733591 0.5 5.3 5 3 long tibia 0.323315191576688 0.59196608497537 0.690733590733591 0.5 5.3 5 3 abnormal squamosal bone morphology 0.364013959706227 0.59196608497537 0.690733590733591 0.5 5.3 5 3 increased susceptibility to autoimmune disorder 0.323315191576688 0.59196608497537 0.690733590733591 0.5 5.3 5 3 abnormal patella morphology 0.38867252669662 0.59196608497537 0.690733590733591 0.5 5.3 5 3 abnormal glycogen homeostasis 0.323315191576688 0.59196608497537 0.690733590733591 0.5 5.3 5 3 impaired behavioral response to cocaine 0.38867252669662 0.59196608497537 0.690733590733591 0.5 5.3 5 3 abnormal sperm axoneme morphology 0.323315191576688 0.59196608497537 0.690733590733591 0.5 5.3 5 3 increased type II pneumocyte number 0.38867252669662 0.59196608497537 0.690733590733591 0.5 5.3 5 3 increased lung compliance 0.364013959706227 0.59196608497537 0.690733590733591 0.5 5.3 5 3 abnormal respiratory motile cilium physiology 0.364013959706227 0.59196608497537 0.690733590733591 0.5 5.3 5 3 abnormal colon goblet cell morphology 0.38867252669662 0.59196608497537 0.690733590733591 0.5 5.3 5 3 abnormal leukocyte migration 0.15145551745706 0.387001129609078 0.690733590733591 0.5 5.3 5 3 abnormal tectorial membrane morphology 0.262950285483601 0.51788506345246 0.690733590733591 0.5 5.3 5 3 waved hair 0.306091873172587 0.591703228221914 0.690733590733591 0.5 5.3 5 3 increased urine glucose level 0.306091873172587 0.591703228221914 0.690733590733591 0.5 5.3 5 3 abnormal trachea morphology 0.306091873172587 0.591703228221914 0.690733590733591 0.5 5.3 5 3 absent palatine bone horizontal plate 0.417532933930119 0.59196608497537 0.690733590733591 0.5 5.3 5 3 abnormal prostate gland epithelium morphology 0.417532933930119 0.59196608497537 0.690733590733591 0.5 5.3 5 3 abnormal epidermis suprabasal layer morphology 0.417532933930119 0.59196608497537 0.690733590733591 0.5 5.3 5 3 abnormal immune cell physiology 0.417532933930119 0.59196608497537 0.690733590733591 0.5 5.3 5 3 abnormal gland morphology 0.417532933930119 0.59196608497537 0.690733590733591 0.5 5.3 5 3 decreased circulating parathyroid hormone level 0.417532933930119 0.59196608497537 0.690733590733591 0.5 5.3 5 3 abnormal glial cell physiology 0.417532933930119 0.59196608497537 0.690733590733591 0.5 5.3 5 3 increased left ventricle diastolic pressure 0.417532933930119 0.59196608497537 0.690733590733591 0.5 5.3 5 3 increased defecation amount 0.417532933930119 0.59196608497537 0.690733590733591 0.5 5.3 5 3 abnormal placental transport 0.417532933930119 0.59196608497537 0.690733590733591 0.5 5.3 5 3 decreased prolactin level 0.417532933930119 0.59196608497537 0.690733590733591 0.5 5.3 5 3 absent coat pigmentation 0.417532933930119 0.59196608497537 0.690733590733591 0.5 5.3 5 3 increased susceptibility to atherosclerosis 0.417532933930119 0.59196608497537 0.690733590733591 0.5 5.3 5 3 absent inguinal lymph nodes 0.417532933930119 0.59196608497537 0.690733590733591 0.5 5.3 5 3 absent axillary lymph nodes 0.417532933930119 0.59196608497537 0.690733590733591 0.5 5.3 5 3 abnormal sperm principal piece morphology 0.417532933930119 0.59196608497537 0.690733590733591 0.5 5.3 5 3 increased serotonin level 0.417532933930119 0.59196608497537 0.690733590733591 0.5 5.3 5 3 abnormal heart and great artery attachment 0.417532933930119 0.59196608497537 0.690733590733591 0.5 5.3 5 3 abnormal pulmonary interalveolar septum morphology 0.417532933930119 0.59196608497537 0.690733590733591 0.5 5.3 5 3 decreased IgM level 0.0821780186838636 0.238945437143321 0.683612625880667 0.494845360824742 5.3 5 3 abnormal thrombosis 0.190158050895891 0.415076319463109 0.677189794836854 0.490196078431373 5.3 5 3 decreased osteoclast cell number 0.214871718625753 0.428451623311872 0.675383955383955 0.488888888888889 5.3 5 3 increased autoantibody level 0.244094639617835 0.483427879020194 0.673022473022473 0.487179487179487 5.3 5 3 abnormal body temperature homeostasis 0.292611317063285 0.56798334076857 0.668451862000249 0.483870967741935 5.3 5 3 abnormal middle ear morphology 0.306991135263379 0.591703228221914 0.666915191053122 0.482758620689655 5.3 5 3 decreased granulocyte number 0.306991135263379 0.591703228221914 0.666915191053122 0.482758620689655 5.3 5 3 enlarged epididymis 0.306991135263379 0.591703228221914 0.666915191053122 0.482758620689655 5.3 5 3 abnormal keratinocyte physiology 0.339329822578135 0.59196608497537 0.663104247104247 0.48 5.3 5 3 decreased acute inflammation 0.339329822578135 0.59196608497537 0.663104247104247 0.48 5.3 5 3 increased sensitivity to induced morbidity/mortality 0.0631457242023091 0.213285020900047 0.660701695484304 0.478260869565217 5.3 5 3 fragile skeleton 0.357659483831044 0.59196608497537 0.660701695484304 0.478260869565217 5.3 5 3 abnormal circulating insulin level 0.357659483831044 0.59196608497537 0.660701695484304 0.478260869565217 5.3 5 3 abnormal sacral vertebrae morphology 0.357659483831044 0.59196608497537 0.660701695484304 0.478260869565217 5.3 5 3 abnormal crista ampullaris morphology 0.357659483831044 0.59196608497537 0.660701695484304 0.478260869565217 5.3 5 3 abnormal B cell morphology 0.357659483831044 0.59196608497537 0.660701695484304 0.478260869565217 5.3 5 3 abnormal lens development 0.357659483831044 0.59196608497537 0.660701695484304 0.478260869565217 5.3 5 3 lung inflammation 0.0994845379463198 0.287990782697714 0.660260049965932 0.477941176470588 5.3 5 3 abnormal vibrissa morphology 0.278314626669087 0.545768729869415 0.657841514984372 0.476190476190476 5.3 5 3 decreased cochlear outer hair cell number 0.377758711884896 0.59196608497537 0.657841514984372 0.476190476190476 5.3 5 3 increased B cell proliferation 0.235003216828334 0.467095886424675 0.655611543747137 0.474576271186441 5.3 5 3 abnormal nail morphology 0.399965564858185 0.59196608497537 0.654379191221297 0.473684210526316 5.3 5 3 flaky skin 0.399965564858185 0.59196608497537 0.654379191221297 0.473684210526316 5.3 5 3 shiny skin 0.399965564858185 0.59196608497537 0.654379191221297 0.473684210526316 5.3 5 3 eyelids fail to open 0.399965564858185 0.59196608497537 0.654379191221297 0.473684210526316 5.3 5 3 decreased liver glycogen level 0.399965564858185 0.59196608497537 0.654379191221297 0.473684210526316 5.3 5 3 abnormal skin physiology 0.332864418679031 0.59196608497537 0.65010220304338 0.470588235294118 5.3 5 3 pancytopenia 0.424729642049338 0.598253105661227 0.65010220304338 0.470588235294118 5.3 5 3 abnormal tendon morphology 0.424729642049338 0.598253105661227 0.65010220304338 0.470588235294118 5.3 5 3 arrested T cell differentiation 0.366133176044106 0.59196608497537 0.644684684684685 0.466666666666667 5.3 5 3 decreased chondrocyte number 0.452667677152171 0.629583923352544 0.644684684684685 0.466666666666667 5.3 5 3 abnormal respiratory system morphology 0.452667677152171 0.629583923352544 0.644684684684685 0.466666666666667 5.3 5 3 arthritis 0.452667677152171 0.629583923352544 0.644684684684685 0.466666666666667 5.3 5 3 lactation failure 0.452667677152171 0.629583923352544 0.644684684684685 0.466666666666667 5.3 5 3 ostium primum atrial septal defect 0.452667677152171 0.629583923352544 0.644684684684685 0.466666666666667 5.3 5 3 abnormal intestinal mucosa morphology 0.325497965117909 0.59196608497537 0.642542875101015 0.465116279069767 5.3 5 3 increased neutrophil cell number 0.171831703376913 0.40207553313014 0.63833311143656 0.462068965517241 5.3 5 3 abnormal leukocyte adhesion 0.355088766208483 0.59196608497537 0.637600237600238 0.461538461538462 5.3 5 3 abnormal stomach morphology 0.404797997230592 0.59196608497537 0.637600237600238 0.461538461538462 5.3 5 3 heart inflammation 0.404797997230592 0.59196608497537 0.637600237600238 0.461538461538462 5.3 5 3 increased susceptibility to injury 0.317961905403606 0.59196608497537 0.637600237600238 0.461538461538462 5.3 5 3 abnormal mast cell morphology 0.484658369269176 0.670702472076258 0.637600237600238 0.461538461538462 5.3 5 3 abnormal renal/urinary system morphology 0.484658369269176 0.670702472076258 0.637600237600238 0.461538461538462 5.3 5 3 abnormal sympathetic ganglion morphology 0.484658369269176 0.670702472076258 0.637600237600238 0.461538461538462 5.3 5 3 tight skin 0.484658369269176 0.670702472076258 0.637600237600238 0.461538461538462 5.3 5 3 pup cannibalization 0.484658369269176 0.670702472076258 0.637600237600238 0.461538461538462 5.3 5 3 abnormal digestion 0.484658369269176 0.670702472076258 0.637600237600238 0.461538461538462 5.3 5 3 absent lateral semicircular canal 0.484658369269176 0.670702472076258 0.637600237600238 0.461538461538462 5.3 5 3 abnormal insulin secretion 0.484658369269176 0.670702472076258 0.637600237600238 0.461538461538462 5.3 5 3 decreased endocochlear potential 0.484658369269176 0.670702472076258 0.637600237600238 0.461538461538462 5.3 5 3 increased renin activity 0.484658369269176 0.670702472076258 0.637600237600238 0.461538461538462 5.3 5 3 abnormal hair follicle inner root sheath morphology 0.484658369269176 0.670702472076258 0.637600237600238 0.461538461538462 5.3 5 3 abnormal T cell activation 0.282303111960845 0.553371939324352 0.634728164457894 0.459459459459459 5.3 5 3 hypopigmentation 0.426642676689729 0.60032124770336 0.633172458172458 0.458333333333333 5.3 5 3 increased circulating total protein level 0.426642676689729 0.60032124770336 0.633172458172458 0.458333333333333 5.3 5 3 abnormal humoral immune response 0.248945760503945 0.492839299047802 0.631527854384997 0.457142857142857 5.3 5 3 delayed wound healing 0.359254850190347 0.59196608497537 0.630669800235018 0.456521739130435 5.3 5 3 abnormal cytokine secretion 0.214025027885054 0.426934448166858 0.627939627939628 0.454545454545455 5.3 5 3 absent vibrissae 0.406962425647893 0.59196608497537 0.627939627939628 0.454545454545455 5.3 5 3 abnormal T-helper 2 physiology 0.34830185376749 0.59196608497537 0.627939627939628 0.454545454545455 5.3 5 3 decreased macrophage cell number 0.374541843107111 0.59196608497537 0.627939627939628 0.454545454545455 5.3 5 3 abnormal retinal layer morphology 0.450516312145608 0.629583923352544 0.627939627939628 0.454545454545455 5.3 5 3 decreased susceptibility to viral infection induced morbidity/mortality 0.450516312145608 0.629583923352544 0.627939627939628 0.454545454545455 5.3 5 3 impaired humoral immune response 0.450516312145608 0.629583923352544 0.627939627939628 0.454545454545455 5.3 5 3 absent semicircular canals 0.522014657158018 0.707635672850446 0.627939627939628 0.454545454545455 5.3 5 3 decreased atrioventricular cushion size 0.522014657158018 0.707635672850446 0.627939627939628 0.454545454545455 5.3 5 3 increased mast cell number 0.522014657158018 0.707635672850446 0.627939627939628 0.454545454545455 5.3 5 3 vasculitis 0.522014657158018 0.707635672850446 0.627939627939628 0.454545454545455 5.3 5 3 abnormal larynx morphology 0.522014657158018 0.707635672850446 0.627939627939628 0.454545454545455 5.3 5 3 variable body spotting 0.522014657158018 0.707635672850446 0.627939627939628 0.454545454545455 5.3 5 3 abnormal nerve fiber response 0.522014657158018 0.707635672850446 0.627939627939628 0.454545454545455 5.3 5 3 abnormal hair medulla 0.522014657158018 0.707635672850446 0.627939627939628 0.454545454545455 5.3 5 3 increased subcutaneous adipose tissue amount 0.522014657158018 0.707635672850446 0.627939627939628 0.454545454545455 5.3 5 3 abnormal cytotoxic T cell physiology 0.390690970920667 0.59196608497537 0.624949439235154 0.452380952380952 5.3 5 3 decreased neuronal precursor cell number 0.426680589322428 0.60032124770336 0.623888404533566 0.451612903225806 5.3 5 3 abnormal T cell proliferation 0.426680589322428 0.60032124770336 0.623888404533566 0.451612903225806 5.3 5 3 decreased IgG level 0.287750334151179 0.563827456637304 0.622282514174406 0.45045045045045 5.3 5 3 abnormal Peyer's patch T cell area morphology 0.476771312600945 0.661812857195787 0.621660231660232 0.45 5.3 5 3 decreased skin tensile strength 0.476771312600945 0.661812857195787 0.621660231660232 0.45 5.3 5 3 abnormal male reproductive system physiology 0.476771312600945 0.661812857195787 0.621660231660232 0.45 5.3 5 3 increased susceptibility to bacterial infection induced morbidity/mortality 0.378952700805266 0.59196608497537 0.613985413985414 0.444444444444444 5.3 5 3 wrinkled skin 0.47062926164748 0.65383428558956 0.613985413985414 0.444444444444444 5.3 5 3 abnormal iron level 0.505861202427459 0.687987829982671 0.613985413985414 0.444444444444444 5.3 5 3 abnormal white adipose tissue morphology 0.505861202427459 0.687987829982671 0.613985413985414 0.444444444444444 5.3 5 3 abnormal macrophage chemotaxis 0.505861202427459 0.687987829982671 0.613985413985414 0.444444444444444 5.3 5 3 abnormal immune system physiology 0.327493725750659 0.59196608497537 0.612747540166895 0.443548387096774 5.3 5 3 decreased IgA level 0.423127769736569 0.596334463014003 0.611033561033561 0.442307692307692 5.3 5 3 decreased osteoblast cell number 0.465460852202258 0.646834564163752 0.609470815353168 0.441176470588235 5.3 5 3 abnormal stomach mucosa morphology 0.495245633491698 0.676369223655066 0.60784555984556 0.44 5.3 5 3 increased tumor growth/size 0.46092717342893 0.640713240516605 0.606497786985592 0.439024390243902 5.3 5 3 abnormal hair shaft morphology 0.456846624881199 0.635218546334255 0.604391891891892 0.4375 5.3 5 3 abnormal crypts of Lieberkuhn morphology 0.48717321880054 0.673995206766598 0.604391891891892 0.4375 5.3 5 3 abnormal pituitary gland morphology 0.538382741780006 0.728632791173975 0.604391891891892 0.4375 5.3 5 3 sepsis 0.538382741780006 0.728632791173975 0.604391891891892 0.4375 5.3 5 3 abnormal Langerhans cell physiology 0.538382741780006 0.728632791173975 0.604391891891892 0.4375 5.3 5 3 abnormal urinary bladder physiology 0.538382741780006 0.728632791173975 0.604391891891892 0.4375 5.3 5 3 abnormal pulmonary alveolus wall morphology 0.538382741780006 0.728632791173975 0.604391891891892 0.4375 5.3 5 3 pancreas inflammation 0.52194464161835 0.707635672850446 0.600637904985731 0.434782608695652 5.3 5 3 abnormal regulatory T cell physiology 0.52194464161835 0.707635672850446 0.600637904985731 0.434782608695652 5.3 5 3 abnormal stria vascularis morphology 0.535073868755649 0.725140968961959 0.592057363485935 0.428571428571429 5.3 5 3 increased incidence of induced tumors 0.551030763137982 0.735393988839982 0.592057363485935 0.428571428571429 5.3 5 3 increased vasoconstriction 0.551030763137982 0.735393988839982 0.592057363485935 0.428571428571429 5.3 5 3 abnormal vasoconstriction 0.575141676441389 0.750020927993685 0.592057363485935 0.428571428571429 5.3 5 3 absent visceral yolk sac blood islands 0.575141676441389 0.750020927993685 0.592057363485935 0.428571428571429 5.3 5 3 abnormal antigen presentation 0.575141676441389 0.750020927993685 0.592057363485935 0.428571428571429 5.3 5 3 abnormal hair cuticle 0.575141676441389 0.750020927993685 0.592057363485935 0.428571428571429 5.3 5 3 abnormal iris pigmentation 0.575141676441389 0.750020927993685 0.592057363485935 0.428571428571429 5.3 5 3 premature hair loss 0.575141676441389 0.750020927993685 0.592057363485935 0.428571428571429 5.3 5 3 increased pulmonary respiratory rate 0.575141676441389 0.750020927993685 0.592057363485935 0.428571428571429 5.3 5 3 abnormal renal reabsorbtion 0.575141676441389 0.750020927993685 0.592057363485935 0.428571428571429 5.3 5 3 abnormal NK cell physiology 0.509065188724341 0.692156139355998 0.588822077346667 0.426229508196721 5.3 5 3 abnormal T cell subpopulation ratio 0.546275908491964 0.735393988839982 0.586076986076986 0.424242424242424 5.3 5 3 impaired natural killer cell mediated cytotoxicity 0.543600018090479 0.735393988839982 0.581670392196708 0.421052631578947 5.3 5 3 autoimmune response 0.570741627187918 0.745847017404752 0.579324947066883 0.419354838709677 5.3 5 3 abnormal inflammatory response 0.56706989697992 0.741243493818997 0.575611325611326 0.416666666666667 5.3 5 3 abnormal glossopharyngeal nerve morphology 0.617259036059016 0.800805853051176 0.575611325611326 0.416666666666667 5.3 5 3 small thyroid gland 0.617259036059016 0.800805853051176 0.575611325611326 0.416666666666667 5.3 5 3 abnormal alisphenoid bone morphology 0.617259036059016 0.800805853051176 0.575611325611326 0.416666666666667 5.3 5 3 impaired sperm capacitation 0.617259036059016 0.800805853051176 0.575611325611326 0.416666666666667 5.3 5 3 small parietal bone 0.617259036059016 0.800805853051176 0.575611325611326 0.416666666666667 5.3 5 3 decreased compensatory feeding amount 0.617259036059016 0.800805853051176 0.575611325611326 0.416666666666667 5.3 5 3 stomach inflammation 0.596647819296233 0.777862395439927 0.571641592331247 0.413793103448276 5.3 5 3 nephrocalcinosis 0.617939911591475 0.800805853051176 0.568839427662957 0.411764705882353 5.3 5 3 increased activated T cell number 0.620617690748088 0.800805853051176 0.565145665145665 0.409090909090909 5.3 5 3 abnormal palate morphology 0.624098339007716 0.800805853051176 0.562819962819963 0.407407407407407 5.3 5 3 decreased susceptibility to parasitic infection 0.627920011874019 0.800805853051176 0.561221042471043 0.40625 5.3 5 3 decreased inflammatory response 0.65060559230882 0.800805853051176 0.559165287736716 0.404761904761905 5.3 5 3 brain inflammation 0.653612810880619 0.800805853051176 0.552586872586873 0.4 5.3 5 3 joint inflammation 0.656791009300867 0.800805853051176 0.552586872586873 0.4 5.3 5 3 increased urine calcium level 0.653612810880619 0.800805853051176 0.552586872586873 0.4 5.3 5 3 nuclear cataracts 0.653612810880619 0.800805853051176 0.552586872586873 0.4 5.3 5 3 conjunctivitis 0.684050365188633 0.823210103244667 0.540574114487158 0.391304347826087 5.3 5 3 increased susceptibility to fungal infection 0.684050365188633 0.823210103244667 0.540574114487158 0.391304347826087 5.3 5 3 decreased susceptibility to induced arthritis 0.741916915139405 0.875898588708719 0.533197859513649 0.385964912280702 5.3 5 3 abnormal membranous labyrinth morphology 0.700134452802667 0.832099594527775 0.531333531333531 0.384615384615385 5.3 5 3 abnormal GABAergic neuron morphology 0.700134452802667 0.832099594527775 0.531333531333531 0.384615384615385 5.3 5 3 increased circulating thyroid-stimulating hormone level 0.700134452802667 0.832099594527775 0.531333531333531 0.384615384615385 5.3 5 3 decreased luteinizing hormone level 0.700134452802667 0.832099594527775 0.531333531333531 0.384615384615385 5.3 5 3 abnormal gut flora balance 0.700134452802667 0.832099594527775 0.531333531333531 0.384615384615385 5.3 5 3 abnormal leukocyte cell number 0.710464200797195 0.84417468329736 0.531333531333531 0.384615384615385 5.3 5 3 abnormal lens fiber morphology 0.726658011957081 0.858495276534428 0.531333531333531 0.384615384615385 5.3 5 3 abnormal bile salt homeostasis 0.716740224876087 0.851428514507769 0.526273211987498 0.380952380952381 5.3 5 3 abnormal intestinal absorption 0.727835969813384 0.859478744320338 0.518050193050193 0.375 5.3 5 3 abnormal wound healing 0.727835969813384 0.859478744320338 0.518050193050193 0.375 5.3 5 3 abnormal immune system morphology 0.799245929382377 0.915391873667085 0.510542219237871 0.369565217391304 5.3 5 3 osteoarthritis 0.751321526898777 0.886160406904082 0.508961593172119 0.368421052631579 5.3 5 3 salivary gland inflammation 0.779698694423921 0.915391873667085 0.506537966537967 0.366666666666667 5.3 5 3 abnormal estrous cycle 0.779698694423921 0.915391873667085 0.506537966537967 0.366666666666667 5.3 5 3 abnormal feces composition 0.789560262324303 0.915391873667085 0.497328185328185 0.36 5.3 5 3 abnormal fluid regulation 0.769574884114487 0.907044550691678 0.493381136238279 0.357142857142857 5.3 5 3 abnormal olfactory system physiology 0.769574884114487 0.907044550691678 0.493381136238279 0.357142857142857 5.3 5 3 increased B-1 B cell number 0.769574884114487 0.907044550691678 0.493381136238279 0.357142857142857 5.3 5 3 abnormal spleen germinal center morphology 0.805470560527713 0.915935094542942 0.493381136238279 0.357142857142857 5.3 5 3 decreased susceptibility to bacterial infection induced morbidity/mortality 0.819737788093014 0.931307489326957 0.490198032133516 0.354838709677419 5.3 5 3 increased susceptibility to viral infection induced morbidity/mortality 0.832616939932582 0.9455077096929 0.487576652282535 0.352941176470588 5.3 5 3 abnormal thymocyte activation 0.803933912447016 0.915391873667085 0.483513513513513 0.35 5.3 5 3 abnormal circulating cytokine level 0.803933912447016 0.915391873667085 0.483513513513513 0.35 5.3 5 3 abnormal circulating glucose level 0.843254954385061 0.956714571964807 0.476367993609373 0.344827586206897 5.3 5 3 increased double-positive T cell number 0.843254954385061 0.956714571964807 0.476367993609373 0.344827586206897 5.3 5 3 increased susceptibility to parasitic infection 0.941794056929015 1 0.475838695838696 0.344444444444444 5.3 5 3 abnormal lymph node B cell domain morphology 0.825966821521297 0.938170076956268 0.460489060489061 0.333333333333333 5.3 5 3 abnormal Peyer's patch follicle morphology 0.837037548190077 0.950093954425196 0.460489060489061 0.333333333333333 5.3 5 3 impaired leukocyte tethering or rolling 0.837037548190077 0.950093954425196 0.460489060489061 0.333333333333333 5.3 5 3 hypoalgesia 0.847530756232481 0.961127310749166 0.460489060489061 0.333333333333333 5.3 5 3 dry skin 0.847530756232481 0.961127310749166 0.460489060489061 0.333333333333333 5.3 5 3 abnormal mouth morphology 0.870571754115803 0.982999200346374 0.431708494208494 0.3125 5.3 5 3 abnormal intestinal lipid absorption 0.870571754115803 0.982999200346374 0.431708494208494 0.3125 5.3 5 3 increased susceptibility to induced arthritis 0.918916637139447 1 0.428731194248436 0.310344827586207 5.3 5 3 decreased airway responsiveness 0.982921581759495 1 0.313969813969814 0.227272727272727 5.3 5 3 abnormal AMPA-mediated synaptic currents 1.61515728644052e-05 0.000295419393383881 1.50731707317073 1 5.1 5 1 jumpy 0.00402211929736248 0.0284233572505374 1.50731707317073 1 5.1 5 1 absent ectoplacental cone 0.00402211929736248 0.0284233572505374 1.50731707317073 1 5.1 5 1 reduced NMDA-mediated synaptic currents 0.00402211929736248 0.0284233572505374 1.50731707317073 1 5.1 5 1 chromatolysis 0.00402211929736248 0.0284233572505374 1.50731707317073 1 5.1 5 1 increased post-tetanic potentiation 0.00402211929736248 0.0284233572505374 1.50731707317073 1 5.1 5 1 abnormal hippocampal fimbria morphology 0.00402211929736248 0.0284233572505374 1.50731707317073 1 5.1 5 1 increased glycerol level 0.00402211929736248 0.0284233572505374 1.50731707317073 1 5.1 5 1 ureter obstruction 0.00402211929736248 0.0284233572505374 1.50731707317073 1 5.1 5 1 abnormal physical strength 0.00402211929736248 0.0284233572505374 1.50731707317073 1 5.1 5 1 variegated coat color 0.00402211929736248 0.0284233572505374 1.50731707317073 1 5.1 5 1 absent sperm mitochondrial sheath 0.00402211929736248 0.0284233572505374 1.50731707317073 1 5.1 5 1 abnormal olfactory bulb layer morphology 0.00402211929736248 0.0284233572505374 1.50731707317073 1 5.1 5 1 ectopic hippocampus pyramidal cells 0.00402211929736248 0.0284233572505374 1.50731707317073 1 5.1 5 1 increased total lung capacity 0.00402211929736248 0.0284233572505374 1.50731707317073 1 5.1 5 1 delayed limb development 0.00402211929736248 0.0284233572505374 1.50731707317073 1 5.1 5 1 abnormal excitatory synapse morphology 0.00402211929736248 0.0284233572505374 1.50731707317073 1 5.1 5 1 absent neurocranium 0.0100869696448974 0.0592292238098131 1.50731707317073 1 5.1 5 1 ovary hyperplasia 0.0100869696448974 0.0592292238098131 1.50731707317073 1 5.1 5 1 skin hyperplasia 0.0100869696448974 0.0592292238098131 1.50731707317073 1 5.1 5 1 epidermal cyst 0.0100869696448974 0.0592292238098131 1.50731707317073 1 5.1 5 1 abnormal hypodermis morphology 0.0100869696448974 0.0592292238098131 1.50731707317073 1 5.1 5 1 abnormal olfactory cortex morphology 0.0100869696448974 0.0592292238098131 1.50731707317073 1 5.1 5 1 abnormal hemoglobin content 0.0100869696448974 0.0592292238098131 1.50731707317073 1 5.1 5 1 increased placenta apoptosis 0.0100869696448974 0.0592292238098131 1.50731707317073 1 5.1 5 1 abnormal mismatch repair 0.0100869696448974 0.0592292238098131 1.50731707317073 1 5.1 5 1 abnormal olfactory bulb granule cell layer morphology 0.0100869696448974 0.0592292238098131 1.50731707317073 1 5.1 5 1 increased mammary gland epithelial cell proliferation 0.0100869696448974 0.0592292238098131 1.50731707317073 1 5.1 5 1 fused right lung lobes 0.0100869696448974 0.0592292238098131 1.50731707317073 1 5.1 5 1 abnormal lung alveolus development 0.0100869696448974 0.0592292238098131 1.50731707317073 1 5.1 5 1 decreased Paneth cell number 0.0100869696448974 0.0592292238098131 1.50731707317073 1 5.1 5 1 fatigue 4.05169236297486e-05 0.000669673405508303 1.50731707317073 1 5.1 5 1 decreased aerobic running capacity 0.000639418931808422 0.00643516055544679 1.50731707317073 1 5.1 5 1 abnormal skin development 0.000639418931808422 0.00643516055544679 1.50731707317073 1 5.1 5 1 tau protein deposits 0.000639418931808422 0.00643516055544679 1.50731707317073 1 5.1 5 1 ectrodactyly 0.000639418931808422 0.00643516055544679 1.50731707317073 1 5.1 5 1 abnormal olfactory bulb glomerular layer morphology 0.000639418931808422 0.00643516055544679 1.50731707317073 1 5.1 5 1 abnormal olfactory bulb mitral cell layer morphology 0.000639418931808422 0.00643516055544679 1.50731707317073 1 5.1 5 1 abnormal anterior commissure pars posterior morphology 0.000639418931808422 0.00643516055544679 1.50731707317073 1 5.1 5 1 axonal dystrophy 6.43833928936744e-06 0.000131273516248373 1.50731707317073 1 5.1 5 1 decreased effector memory CD4-positive, alpha-beta T cell number 0.000254930498759095 0.00305609453331687 1.50731707317073 1 5.1 5 1 abnormal circulating alanine transaminase level 0.00160372490646648 0.0138516170306784 1.50731707317073 1 5.1 5 1 abnormal sperm annulus morphology 0.00160372490646648 0.0138516170306784 1.50731707317073 1 5.1 5 1 abnormal brain ependyma motile cilium physiology 0.00160372490646648 0.0138516170306784 1.50731707317073 1 5.1 5 1 ductus venosus stenosis 0.00160372490646648 0.0138516170306784 1.50731707317073 1 5.1 5 1 impaired synaptic plasticity 3.47451504686253e-11 2.08261594676399e-09 1.41865136298422 0.941176470588235 5.1 5 1 dystonia 1.0251009712494e-05 0.000199995189488854 1.41310975609756 0.9375 5.1 5 1 abnormal pup retrieval 2.41744192541661e-05 0.000421992055401671 1.40682926829268 0.933333333333333 5.1 5 1 decreased CNS synapse formation 5.67743774208197e-05 0.000891017437440309 1.39965156794425 0.928571428571429 5.1 5 1 increased synaptic depression 0.000132710375764858 0.00182385115864687 1.39136960600375 0.923076923076923 5.1 5 1 decreased synaptic depression 0.000308535782048527 0.00355316091595237 1.38170731707317 0.916666666666667 5.1 5 1 abnormal vascular endothelial cell development 0.000308535782048527 0.00355316091595237 1.38170731707317 0.916666666666667 5.1 5 1 embryonic lethality between implantation and placentation, incomplete penetrance 0.000308535782048527 0.00355316091595237 1.38170731707317 0.916666666666667 5.1 5 1 abnormal channel response 9.15375547731179e-07 2.28843886932795e-05 1.37028824833703 0.909090909090909 5.1 5 1 enlarged cranium 0.000712804168123538 0.00702217967606852 1.37028824833703 0.909090909090909 5.1 5 1 abnormal proximal-distal axis patterning 0.000712804168123538 0.00702217967606852 1.37028824833703 0.909090909090909 5.1 5 1 abnormal spinal cord ventral horn morphology 0.000712804168123538 0.00702217967606852 1.37028824833703 0.909090909090909 5.1 5 1 abnormal brain ependyma motile cilium morphology 0.000712804168123538 0.00702217967606852 1.37028824833703 0.909090909090909 5.1 5 1 decreased embryonic cilium length 0.000712804168123538 0.00702217967606852 1.37028824833703 0.909090909090909 5.1 5 1 thin hypoglossal nerve 0.000712804168123538 0.00702217967606852 1.37028824833703 0.909090909090909 5.1 5 1 decreased paired-pulse facilitation 4.77192190757442e-06 0.000101022602085884 1.35658536585366 0.9 5.1 5 1 impaired social transmission of food preference 0.00163459947488285 0.0139967855207266 1.35658536585366 0.9 5.1 5 1 absent seminal vesicle 0.00163459947488285 0.0139967855207266 1.35658536585366 0.9 5.1 5 1 abnormal pillar cell morphology 0.00163459947488285 0.0139967855207266 1.35658536585366 0.9 5.1 5 1 abnormal cerebellar granule cell migration 0.00163459947488285 0.0139967855207266 1.35658536585366 0.9 5.1 5 1 thin ventricle myocardium compact layer 0.00163459947488285 0.0139967855207266 1.35658536585366 0.9 5.1 5 1 enhanced paired-pulse facilitation 1.55669431159329e-08 5.91188461373125e-07 1.35658536585366 0.9 5.1 5 1 abnormal synaptic transmission 1.55669431159329e-08 5.91188461373125e-07 1.35658536585366 0.9 5.1 5 1 abnormal excitatory postsynaptic currents 4.47531150426309e-20 8.24617582729959e-18 1.35272045028143 0.897435897435897 5.1 5 1 absent long term depression 3.52600102883938e-08 1.19332347744734e-06 1.35138772077376 0.896551724137931 5.1 5 1 decreased susceptibility to pharmacologically induced seizures 1.78869255028691e-07 5.26552984477952e-06 1.33983739837398 0.888888888888889 5.1 5 1 polycythemia 0.00371532639620304 0.0274239596752376 1.33983739837398 0.888888888888889 5.1 5 1 abnormal NMDA-mediated synaptic currents 0.00371532639620304 0.0274239596752376 1.33983739837398 0.888888888888889 5.1 5 1 decreased cellular sensitivity to ionizing radiation 0.00371532639620304 0.0274239596752376 1.33983739837398 0.888888888888889 5.1 5 1 abnormal CNS synapse formation 0.00371532639620304 0.0274239596752376 1.33983739837398 0.888888888888889 5.1 5 1 abnormal hippocampus granule cell morphology 0.00371532639620304 0.0274239596752376 1.33983739837398 0.888888888888889 5.1 5 1 shortened ST segment 0.00371532639620304 0.0274239596752376 1.33983739837398 0.888888888888889 5.1 5 1 reduced AMPA-mediated synaptic currents 0.00371532639620304 0.0274239596752376 1.33983739837398 0.888888888888889 5.1 5 1 cerebellum atrophy 0.00371532639620304 0.0274239596752376 1.33983739837398 0.888888888888889 5.1 5 1 abnormal brain wave pattern 4.36667052418105e-13 3.50390094480657e-11 1.33339587242026 0.884615384615385 5.1 5 1 abnormal glutamate-mediated receptor currents 5.46508689469499e-05 0.000860405294338847 1.3299856527977 0.882352941176471 5.1 5 1 absence seizures 5.46508689469499e-05 0.000860405294338847 1.3299856527977 0.882352941176471 5.1 5 1 abnormal involuntary movement 5.46508689469499e-05 0.000860405294338847 1.3299856527977 0.882352941176471 5.1 5 1 enhanced behavioral response to cocaine 5.46508689469499e-05 0.000860405294338847 1.3299856527977 0.882352941176471 5.1 5 1 absent skin pigmentation 0.0083538667290729 0.0503153595364863 1.31890243902439 0.875 5.1 5 1 abnormal neuron apoptosis 0.0083538667290729 0.0503153595364863 1.31890243902439 0.875 5.1 5 1 colon polyps 0.0083538667290729 0.0503153595364863 1.31890243902439 0.875 5.1 5 1 abnormal ovary development 0.0083538667290729 0.0503153595364863 1.31890243902439 0.875 5.1 5 1 abnormal lateral ganglionic eminence morphology 0.0083538667290729 0.0503153595364863 1.31890243902439 0.875 5.1 5 1 abnormal kidney epithelium morphology 0.0083538667290729 0.0503153595364863 1.31890243902439 0.875 5.1 5 1 abnormal choroid pigmentation 0.0083538667290729 0.0503153595364863 1.31890243902439 0.875 5.1 5 1 non-pigmented tail tip 0.0083538667290729 0.0503153595364863 1.31890243902439 0.875 5.1 5 1 abnormal olfactory tract morphology 0.0083538667290729 0.0503153595364863 1.31890243902439 0.875 5.1 5 1 abnormal epidermal lamellar body morphology 0.0083538667290729 0.0503153595364863 1.31890243902439 0.875 5.1 5 1 abnormal meiotic spindle morphology 0.0083538667290729 0.0503153595364863 1.31890243902439 0.875 5.1 5 1 decreased hippocampus pyramidal cell number 0.0083538667290729 0.0503153595364863 1.31890243902439 0.875 5.1 5 1 increased caudal vertebrae number 0.0083538667290729 0.0503153595364863 1.31890243902439 0.875 5.1 5 1 pleural effusion 0.0083538667290729 0.0503153595364863 1.31890243902439 0.875 5.1 5 1 abnormal visual evoked potential 0.0083538667290729 0.0503153595364863 1.31890243902439 0.875 5.1 5 1 abnormal umbilical vein topology 0.0083538667290729 0.0503153595364863 1.31890243902439 0.875 5.1 5 1 abnormal object recognition memory 7.44125748863597e-08 2.37309333371564e-06 1.31282454760031 0.870967741935484 5.1 5 1 audiogenic seizures 0.000268674105504068 0.00317483933838475 1.30634146341463 0.866666666666667 5.1 5 1 abnormal seizure response to electrical stimulation 0.000268674105504068 0.00317483933838475 1.30634146341463 0.866666666666667 5.1 5 1 abnormal cerebral aqueduct morphology 0.000268674105504068 0.00317483933838475 1.30634146341463 0.866666666666667 5.1 5 1 abnormal cerebral cortex pyramidal cell morphology 9.56373091424567e-06 0.000188061507108191 1.30177383592018 0.863636363636364 5.1 5 1 increased hemangioma incidence 0.000588326365829085 0.00608508039500977 1.29198606271777 0.857142857142857 5.1 5 1 abnormal voluntary movement 0.000588326365829085 0.00608508039500977 1.29198606271777 0.857142857142857 5.1 5 1 abnormal viscerocranium morphology 0.000588326365829085 0.00608508039500977 1.29198606271777 0.857142857142857 5.1 5 1 broad head 0.0185324856427385 0.0939848278008398 1.29198606271777 0.857142857142857 5.1 5 1 absent hair follicles 0.0185324856427385 0.0939848278008398 1.29198606271777 0.857142857142857 5.1 5 1 polyphalangy 0.0185324856427385 0.0939848278008398 1.29198606271777 0.857142857142857 5.1 5 1 mottled coat 0.0185324856427385 0.0939848278008398 1.29198606271777 0.857142857142857 5.1 5 1 mammary gland hyperplasia 0.0185324856427385 0.0939848278008398 1.29198606271777 0.857142857142857 5.1 5 1 abnormal oculomotor nerve morphology 0.0185324856427385 0.0939848278008398 1.29198606271777 0.857142857142857 5.1 5 1 decreased Schwann cell number 0.0185324856427385 0.0939848278008398 1.29198606271777 0.857142857142857 5.1 5 1 retina hyperplasia 0.0185324856427385 0.0939848278008398 1.29198606271777 0.857142857142857 5.1 5 1 excessive tearing 0.0185324856427385 0.0939848278008398 1.29198606271777 0.857142857142857 5.1 5 1 abnormal circulating free fatty acids level 0.0185324856427385 0.0939848278008398 1.29198606271777 0.857142857142857 5.1 5 1 abnormal axial mesoderm 0.0185324856427385 0.0939848278008398 1.29198606271777 0.857142857142857 5.1 5 1 abnormal melanocyte morphology 0.0185324856427385 0.0939848278008398 1.29198606271777 0.857142857142857 5.1 5 1 abnormal adrenal gland physiology 0.0185324856427385 0.0939848278008398 1.29198606271777 0.857142857142857 5.1 5 1 decreased mortality induced by ionizing radiation 0.0185324856427385 0.0939848278008398 1.29198606271777 0.857142857142857 5.1 5 1 absent tunnel of Corti 0.0185324856427385 0.0939848278008398 1.29198606271777 0.857142857142857 5.1 5 1 decreased cardiomyocyte apoptosis 0.0185324856427385 0.0939848278008398 1.29198606271777 0.857142857142857 5.1 5 1 abnormal Purkinje cell innervation 0.0185324856427385 0.0939848278008398 1.29198606271777 0.857142857142857 5.1 5 1 abnormal optic tract morphology 0.0185324856427385 0.0939848278008398 1.29198606271777 0.857142857142857 5.1 5 1 abnormal talus morphology 0.0185324856427385 0.0939848278008398 1.29198606271777 0.857142857142857 5.1 5 1 abnormal body temperature 0.0185324856427385 0.0939848278008398 1.29198606271777 0.857142857142857 5.1 5 1 decreased skeletal muscle glycogen level 0.0185324856427385 0.0939848278008398 1.29198606271777 0.857142857142857 5.1 5 1 abnormal outer hair cell kinocilium morphology 0.0185324856427385 0.0939848278008398 1.29198606271777 0.857142857142857 5.1 5 1 fragmented Meckel's cartilage 0.0185324856427385 0.0939848278008398 1.29198606271777 0.857142857142857 5.1 5 1 embryo tumor 0.0185324856427385 0.0939848278008398 1.29198606271777 0.857142857142857 5.1 5 1 abnormal neuron proliferation 4.50747305876701e-05 0.000737653896952825 1.28121951219512 0.85 5.1 5 1 dystrophic cardiac calcinosis 0.00127557551660871 0.0114532729939482 1.27542213883677 0.846153846153846 5.1 5 1 abnormal aorta tunica media morphology 0.00127557551660871 0.0114532729939482 1.27542213883677 0.846153846153846 5.1 5 1 absent hypoglossal nerve 0.00127557551660871 0.0114532729939482 1.27542213883677 0.846153846153846 5.1 5 1 abnormal metatarsal bone morphology 9.67650063037024e-05 0.00139134655017607 1.26931964056483 0.842105263157895 5.1 5 1 embryonic lethality between implantation and somite formation, incomplete penetrance 9.67650063037024e-05 0.00139134655017607 1.26931964056483 0.842105263157895 5.1 5 1 abnormal nest building behavior 7.6786180487465e-06 0.000152195716304836 1.26614634146341 0.84 5.1 5 1 abnormal CNS synaptic transmission 2.45854292381961e-19 3.8222659518758e-17 1.26371027346637 0.838383838383838 5.1 5 1 abnormal contextual conditioning behavior 3.1142980719358e-11 1.93670411348508e-09 1.26066518847007 0.836363636363636 5.1 5 1 abnormal mating frequency 0.0027341460984986 0.0212205566927153 1.25609756097561 0.833333333333333 5.1 5 1 abnormal respiratory function 0.0027341460984986 0.0212205566927153 1.25609756097561 0.833333333333333 5.1 5 1 increased growth rate 0.0027341460984986 0.0212205566927153 1.25609756097561 0.833333333333333 5.1 5 1 abnormal corticospinal tract morphology 0.0027341460984986 0.0212205566927153 1.25609756097561 0.833333333333333 5.1 5 1 abnormal defecation 0.0027341460984986 0.0212205566927153 1.25609756097561 0.833333333333333 5.1 5 1 abnormal rostral-caudal body axis extension 0.0027341460984986 0.0212205566927153 1.25609756097561 0.833333333333333 5.1 5 1 stria vascularis degeneration 0.0027341460984986 0.0212205566927153 1.25609756097561 0.833333333333333 5.1 5 1 abnormal somatic nervous system physiology 0.0027341460984986 0.0212205566927153 1.25609756097561 0.833333333333333 5.1 5 1 decreased mammary gland epithelial cell proliferation 0.0027341460984986 0.0212205566927153 1.25609756097561 0.833333333333333 5.1 5 1 persistent right dorsal aorta 0.0027341460984986 0.0212205566927153 1.25609756097561 0.833333333333333 5.1 5 1 abnormal urethra morphology 0.0404112213825723 0.160965433449397 1.25609756097561 0.833333333333333 5.1 5 1 hyperresponsive 0.0404112213825723 0.160965433449397 1.25609756097561 0.833333333333333 5.1 5 1 abnormal avoidance learning behavior 0.0404112213825723 0.160965433449397 1.25609756097561 0.833333333333333 5.1 5 1 delayed brain development 0.0404112213825723 0.160965433449397 1.25609756097561 0.833333333333333 5.1 5 1 abnormal parental behavior 0.0404112213825723 0.160965433449397 1.25609756097561 0.833333333333333 5.1 5 1 abnormal otolithic membrane morphology 0.0404112213825723 0.160965433449397 1.25609756097561 0.833333333333333 5.1 5 1 liver cirrhosis 0.0404112213825723 0.160965433449397 1.25609756097561 0.833333333333333 5.1 5 1 decreased otolith number 0.0404112213825723 0.160965433449397 1.25609756097561 0.833333333333333 5.1 5 1 phenotypic reversion 0.0404112213825723 0.160965433449397 1.25609756097561 0.833333333333333 5.1 5 1 loss of hippocampal neurons 0.0404112213825723 0.160965433449397 1.25609756097561 0.833333333333333 5.1 5 1 esophageal atresia 0.0404112213825723 0.160965433449397 1.25609756097561 0.833333333333333 5.1 5 1 abnormal intestinal peristalsis 0.0404112213825723 0.160965433449397 1.25609756097561 0.833333333333333 5.1 5 1 decreased liver function 0.0404112213825723 0.160965433449397 1.25609756097561 0.833333333333333 5.1 5 1 impaired granulosa cell differentiation 0.0404112213825723 0.160965433449397 1.25609756097561 0.833333333333333 5.1 5 1 abnormal metopic suture morphology 0.0404112213825723 0.160965433449397 1.25609756097561 0.833333333333333 5.1 5 1 abnormal cholesterol level 0.0404112213825723 0.160965433449397 1.25609756097561 0.833333333333333 5.1 5 1 small clavicle 0.0404112213825723 0.160965433449397 1.25609756097561 0.833333333333333 5.1 5 1 decreased cochlear microphonics 0.0404112213825723 0.160965433449397 1.25609756097561 0.833333333333333 5.1 5 1 decreased prostate gland weight 0.0404112213825723 0.160965433449397 1.25609756097561 0.833333333333333 5.1 5 1 abnormal heart size 0.0404112213825723 0.160965433449397 1.25609756097561 0.833333333333333 5.1 5 1 abnormal pulmonary respiratory rate 0.0404112213825723 0.160965433449397 1.25609756097561 0.833333333333333 5.1 5 1 decreased platelet ADP level 0.0404112213825723 0.160965433449397 1.25609756097561 0.833333333333333 5.1 5 1 delayed chorioallantoic fusion 0.0404112213825723 0.160965433449397 1.25609756097561 0.833333333333333 5.1 5 1 abnormal aorta tunica adventitia morphology 0.0404112213825723 0.160965433449397 1.25609756097561 0.833333333333333 5.1 5 1 absent tongue 0.0404112213825723 0.160965433449397 1.25609756097561 0.833333333333333 5.1 5 1 increased erythrocyte clearance 0.0404112213825723 0.160965433449397 1.25609756097561 0.833333333333333 5.1 5 1 abnormal oval cell physiology 0.0404112213825723 0.160965433449397 1.25609756097561 0.833333333333333 5.1 5 1 abnormal acute phase protein level 0.0404112213825723 0.160965433449397 1.25609756097561 0.833333333333333 5.1 5 1 myocardium hypoplasia 0.0404112213825723 0.160965433449397 1.25609756097561 0.833333333333333 5.1 5 1 cerebral arteriovenous malformation 0.0404112213825723 0.160965433449397 1.25609756097561 0.833333333333333 5.1 5 1 thick pulmonary valve cusps 0.0404112213825723 0.160965433449397 1.25609756097561 0.833333333333333 5.1 5 1 abnormal intestinal enteroendocrine cell morphology 0.0404112213825723 0.160965433449397 1.25609756097561 0.833333333333333 5.1 5 1 ectopic ureteric bud 0.0404112213825723 0.160965433449397 1.25609756097561 0.833333333333333 5.1 5 1 abnormal kidney collecting duct epithelium morphology 0.0404112213825723 0.160965433449397 1.25609756097561 0.833333333333333 5.1 5 1 abnormal endocrine pancreas development 0.0404112213825723 0.160965433449397 1.25609756097561 0.833333333333333 5.1 5 1 increased bone trabecular spacing 0.0404112213825723 0.160965433449397 1.25609756097561 0.833333333333333 5.1 5 1 decreased hippocampus volume 0.0404112213825723 0.160965433449397 1.25609756097561 0.833333333333333 5.1 5 1 decreased tear production 0.0404112213825723 0.160965433449397 1.25609756097561 0.833333333333333 5.1 5 1 abnormal inhibitory learning 0.0404112213825723 0.160965433449397 1.25609756097561 0.833333333333333 5.1 5 1 decreased retinal apoptosis 0.0404112213825723 0.160965433449397 1.25609756097561 0.833333333333333 5.1 5 1 reduced long term depression 1.09366158904892e-07 3.35862123797429e-06 1.25609756097561 0.833333333333333 5.1 5 1 abnormal mitral valve morphology 0.000205965079401559 0.00256169067505689 1.25609756097561 0.833333333333333 5.1 5 1 abnormal metacarpal bone morphology 0.000205965079401559 0.00256169067505689 1.25609756097561 0.833333333333333 5.1 5 1 darkened coat color 0.000205965079401559 0.00256169067505689 1.25609756097561 0.833333333333333 5.1 5 1 small thoracic cage 0.000205965079401559 0.00256169067505689 1.25609756097561 0.833333333333333 5.1 5 1 increased effector memory CD4-positive, alpha-beta T cell number 0.000205965079401559 0.00256169067505689 1.25609756097561 0.833333333333333 5.1 5 1 abnormal hypoglossal nerve topology 0.000205965079401559 0.00256169067505689 1.25609756097561 0.833333333333333 5.1 5 1 failure to gastrulate 3.39225620463082e-09 1.45486850155503e-07 1.24517497348887 0.826086956521739 5.1 5 1 abnormal chondrocyte physiology 3.42718873009877e-05 0.000583913148364431 1.24517497348887 0.826086956521739 5.1 5 1 seizures 1.09472117783773e-20 2.17849514389708e-18 1.24287548138639 0.824561403508772 5.1 5 1 abnormal inhibitory postsynaptic currents 7.88415355390593e-13 6.22597840169555e-11 1.24131994261119 0.823529411764706 5.1 5 1 abnormal cued conditioning behavior 6.00632870370794e-10 2.95856290108386e-08 1.24131994261119 0.823529411764706 5.1 5 1 enlarged liver sinusoidal spaces 4.80338549027129e-07 1.31057017635557e-05 1.24131994261119 0.823529411764706 5.1 5 1 abnormal adipose tissue morphology 0.000434246232507503 0.00473766448843164 1.24131994261119 0.823529411764706 5.1 5 1 abnormal interatrial septum morphology 0.000434246232507503 0.00473766448843164 1.24131994261119 0.823529411764706 5.1 5 1 hyperlipidemia 0.000434246232507503 0.00473766448843164 1.24131994261119 0.823529411764706 5.1 5 1 abnormal dorsal-ventral axis patterning 0.000434246232507503 0.00473766448843164 1.24131994261119 0.823529411764706 5.1 5 1 abnormal tarsal bone morphology 0.000434246232507503 0.00473766448843164 1.24131994261119 0.823529411764706 5.1 5 1 increased brain size 0.000434246232507503 0.00473766448843164 1.24131994261119 0.823529411764706 5.1 5 1 increased trabecular bone mass 0.000434246232507503 0.00473766448843164 1.24131994261119 0.823529411764706 5.1 5 1 abnormal nervous system electrophysiology 2.20004911813861e-15 2.43227652505324e-13 1.23815331010453 0.821428571428571 5.1 5 1 myoclonus 5.81117320451889e-06 0.00011897360778799 1.23815331010453 0.821428571428571 5.1 5 1 abnormal limb posture 7.15572121030654e-05 0.00108079216671604 1.23325942350333 0.818181818181818 5.1 5 1 social withdrawal 0.00578267835529973 0.0376063069511323 1.23325942350333 0.818181818181818 5.1 5 1 failure of somite differentiation 0.00578267835529973 0.0376063069511323 1.23325942350333 0.818181818181818 5.1 5 1 abnormal fear/anxiety-related behavior 0.00578267835529973 0.0376063069511323 1.23325942350333 0.818181818181818 5.1 5 1 abnormal ureter development 0.00578267835529973 0.0376063069511323 1.23325942350333 0.818181818181818 5.1 5 1 abnormal dorsal-ventral polarity of the somites 0.00578267835529973 0.0376063069511323 1.23325942350333 0.818181818181818 5.1 5 1 abnormal palatal shelf elevation 0.00578267835529973 0.0376063069511323 1.23325942350333 0.818181818181818 5.1 5 1 aorta dilation 0.00578267835529973 0.0376063069511323 1.23325942350333 0.818181818181818 5.1 5 1 reduced sympathetic cervical ganglion size 0.00578267835529973 0.0376063069511323 1.23325942350333 0.818181818181818 5.1 5 1 abnormal excitatory postsynaptic potential 9.40016729236886e-15 8.82374193953492e-13 1.23158834027365 0.817073170731707 5.1 5 1 reduced long term potentiation 3.16629044377314e-19 4.63302792875628e-17 1.22469512195122 0.8125 5.1 5 1 abnormal long term potentiation 2.06134452483352e-06 4.76985535397523e-05 1.22469512195122 0.8125 5.1 5 1 reduced male mating frequency 0.000905829323156253 0.00836085506994872 1.22469512195122 0.8125 5.1 5 1 increased cochlear outer hair cell number 0.000905829323156253 0.00836085506994872 1.22469512195122 0.8125 5.1 5 1 impaired behavioral response to addictive substance 0.000905829323156253 0.00836085506994872 1.22469512195122 0.8125 5.1 5 1 abnormal reproductive system morphology 6.20260629386575e-08 2.0037640462326e-06 1.22020905923345 0.80952380952381 5.1 5 1 abnormal anxiety-related response 0.000148092425553818 0.00193884162402696 1.22020905923345 0.80952380952381 5.1 5 1 abnormal embryonic/fetal subventricular zone morphology 0.000148092425553818 0.00193884162402696 1.22020905923345 0.80952380952381 5.1 5 1 liver hypoplasia 1.91276700448592e-09 8.8021569890595e-08 1.21744840525328 0.807692307692308 5.1 5 1 abnormal dendritic spine morphology 3.89560800009736e-09 1.64272762595075e-07 1.21176470588235 0.803921568627451 5.1 5 1 abnormal axon extension 7.89821805957231e-09 3.14349078770978e-07 1.20585365853659 0.8 5.1 5 1 abnormal hearing physiology 0.00030352610916783 0.00352813643249989 1.20585365853659 0.8 5.1 5 1 abnormal optic stalk morphology 0.00030352610916783 0.00352813643249989 1.20585365853659 0.8 5.1 5 1 abnormal postnatal subventricular zone morphology 0.00030352610916783 0.00352813643249989 1.20585365853659 0.8 5.1 5 1 abnormal response to tactile stimuli 0.00030352610916783 0.00352813643249989 1.20585365853659 0.8 5.1 5 1 retarded hair growth 0.0120382340814838 0.0671414961383204 1.20585365853659 0.8 5.1 5 1 increased cranium width 0.0120382340814838 0.0671414961383204 1.20585365853659 0.8 5.1 5 1 decreased incidence of induced tumors 0.0120382340814838 0.0671414961383204 1.20585365853659 0.8 5.1 5 1 abnormal primordial germ cell migration 0.0120382340814838 0.0671414961383204 1.20585365853659 0.8 5.1 5 1 impaired basement membrane formation 0.0120382340814838 0.0671414961383204 1.20585365853659 0.8 5.1 5 1 abnormal tibialis anterior morphology 0.0120382340814838 0.0671414961383204 1.20585365853659 0.8 5.1 5 1 increased heart rate variability 0.0120382340814838 0.0671414961383204 1.20585365853659 0.8 5.1 5 1 abnormal plasma membrane morphology 0.0120382340814838 0.0671414961383204 1.20585365853659 0.8 5.1 5 1 abnormal utricular macula morphology 0.0120382340814838 0.0671414961383204 1.20585365853659 0.8 5.1 5 1 absent coat pigmentation 0.0120382340814838 0.0671414961383204 1.20585365853659 0.8 5.1 5 1 osteosclerosis 0.0120382340814838 0.0671414961383204 1.20585365853659 0.8 5.1 5 1 abnormal developmental vascular remodeling 0.0120382340814838 0.0671414961383204 1.20585365853659 0.8 5.1 5 1 impaired behavioral response to morphine 0.0120382340814838 0.0671414961383204 1.20585365853659 0.8 5.1 5 1 abnormal sperm principal piece morphology 0.0120382340814838 0.0671414961383204 1.20585365853659 0.8 5.1 5 1 abnormal inferior vena cava valve morphology 0.0120382340814838 0.0671414961383204 1.20585365853659 0.8 5.1 5 1 thick aortic valve cusps 0.0120382340814838 0.0671414961383204 1.20585365853659 0.8 5.1 5 1 sinus bradycardia 0.0120382340814838 0.0671414961383204 1.20585365853659 0.8 5.1 5 1 decreased trabecular bone connectivity density 0.0120382340814838 0.0671414961383204 1.20585365853659 0.8 5.1 5 1 lethality during fetal growth through weaning, complete penetrance 0.0120382340814838 0.0671414961383204 1.20585365853659 0.8 5.1 5 1 decreased circulating lactate level 0.0120382340814838 0.0671414961383204 1.20585365853659 0.8 5.1 5 1 abnormal hippocampus pyramidal cell morphology 1.48239129516664e-06 3.54562341031444e-05 1.20585365853659 0.8 5.1 5 1 absent incisors 0.00186693540712915 0.0155838987423952 1.20585365853659 0.8 5.1 5 1 macrocytosis 0.00186693540712915 0.0155838987423952 1.20585365853659 0.8 5.1 5 1 abnormal olfactory nerve morphology 0.00186693540712915 0.0155838987423952 1.20585365853659 0.8 5.1 5 1 immune system phenotype 0.00186693540712915 0.0155838987423952 1.20585365853659 0.8 5.1 5 1 impaired limb coordination 2.81090999009392e-09 1.22669098251906e-07 1.20027100271003 0.796296296296296 5.1 5 1 increased mortality induced by gamma-irradiation 1.74244588646833e-05 0.000316374754933574 1.19545836837679 0.793103448275862 5.1 5 1 increased susceptibility to pharmacologically induced seizures 4.1509924296505e-15 4.39386964627899e-13 1.19329268292683 0.791666666666667 5.1 5 1 abnormal axon guidance 1.82210724350383e-07 5.30115996282548e-06 1.19183210436756 0.790697674418605 5.1 5 1 kyphoscoliosis 0.000615465353518521 0.00630028834105893 1.18998716302952 0.789473684210526 5.1 5 1 increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 0.000615465353518521 0.00630028834105893 1.18998716302952 0.789473684210526 5.1 5 1 abnormal motor capabilities/coordination/movement 7.23139132093633e-20 1.2405576490227e-17 1.18758314855876 0.787878787878788 5.1 5 1 abnormal brainstem morphology 3.49527138276261e-05 0.000593480379837678 1.18432055749129 0.785714285714286 5.1 5 1 extended life span 0.00379548906946733 0.0276464979803806 1.18432055749129 0.785714285714286 5.1 5 1 amyloid beta deposits 0.00379548906946733 0.0276464979803806 1.18432055749129 0.785714285714286 5.1 5 1 abnormal sagittal suture morphology 0.00379548906946733 0.0276464979803806 1.18432055749129 0.785714285714286 5.1 5 1 increased circulating growth hormone level 0.00379548906946733 0.0276464979803806 1.18432055749129 0.785714285714286 5.1 5 1 spina bifida occulta 0.00379548906946733 0.0276464979803806 1.18432055749129 0.785714285714286 5.1 5 1 testis degeneration 0.00379548906946733 0.0276464979803806 1.18432055749129 0.785714285714286 5.1 5 1 multiple persisting craniopharyngeal ducts 0.00379548906946733 0.0276464979803806 1.18432055749129 0.785714285714286 5.1 5 1 abnormal vitelline vein topology 0.00379548906946733 0.0276464979803806 1.18432055749129 0.785714285714286 5.1 5 1 decreased response to antigen 0.00379548906946733 0.0276464979803806 1.18432055749129 0.785714285714286 5.1 5 1 thick ventricular wall 7.21732991373956e-07 1.83194981228849e-05 1.17644259369423 0.780487804878049 5.1 5 1 decreased anxiety-related response 6.15096509837349e-18 8.74315753268803e-16 1.17644259369423 0.780487804878049 5.1 5 1 short stride length 4.44436357197378e-08 1.45465189280063e-06 1.17570731707317 0.78 5.1 5 1 abnormal spatial learning 3.82958874525138e-23 8.28356695983723e-21 1.17441268891217 0.779141104294479 5.1 5 1 abnormal axon morphology 1.03697660505318e-15 1.25828258783893e-13 1.17235772357724 0.777777777777778 5.1 5 1 axon degeneration 1.55669725507295e-08 5.91188461373125e-07 1.17235772357724 0.777777777777778 5.1 5 1 abnormal limb bone morphology 4.11971360751034e-06 8.83429965403617e-05 1.17235772357724 0.777777777777778 5.1 5 1 increased brain weight 6.9509120839158e-05 0.00106076035636445 1.17235772357724 0.777777777777778 5.1 5 1 underdeveloped hair follicles 0.00123323026837831 0.0111551283366947 1.17235772357724 0.777777777777778 5.1 5 1 decreased lactate dehydrogenase level 0.00123323026837831 0.0111551283366947 1.17235772357724 0.777777777777778 5.1 5 1 abnormal head movements 0.0245887578941175 0.113991163389814 1.17235772357724 0.777777777777778 5.1 5 1 abnormal ion homeostasis 0.0245887578941175 0.113991163389814 1.17235772357724 0.777777777777778 5.1 5 1 abnormal germ cell morphology 0.0245887578941175 0.113991163389814 1.17235772357724 0.777777777777778 5.1 5 1 abnormal vomeronasal organ morphology 0.0245887578941175 0.113991163389814 1.17235772357724 0.777777777777778 5.1 5 1 enlarged otoliths 0.0245887578941175 0.113991163389814 1.17235772357724 0.777777777777778 5.1 5 1 abnormal abdominal wall morphology 0.0245887578941175 0.113991163389814 1.17235772357724 0.777777777777778 5.1 5 1 biliary cyst 0.0245887578941175 0.113991163389814 1.17235772357724 0.777777777777778 5.1 5 1 abnormal artery development 0.0245887578941175 0.113991163389814 1.17235772357724 0.777777777777778 5.1 5 1 premature neuronal precursor differentiation 0.0245887578941175 0.113991163389814 1.17235772357724 0.777777777777778 5.1 5 1 decreased fear-related response 0.0245887578941175 0.113991163389814 1.17235772357724 0.777777777777778 5.1 5 1 abnormal thymus physiology 0.0245887578941175 0.113991163389814 1.17235772357724 0.777777777777778 5.1 5 1 decreased muscle weight 0.0245887578941175 0.113991163389814 1.17235772357724 0.777777777777778 5.1 5 1 decreased cochlear hair cell number 0.0245887578941175 0.113991163389814 1.17235772357724 0.777777777777778 5.1 5 1 increased neuronal precursor cell number 0.0245887578941175 0.113991163389814 1.17235772357724 0.777777777777778 5.1 5 1 abnormal oxygen consumption 0.0245887578941175 0.113991163389814 1.17235772357724 0.777777777777778 5.1 5 1 abnormal inguinal fat pad morphology 0.0245887578941175 0.113991163389814 1.17235772357724 0.777777777777778 5.1 5 1 abnormal optic chiasm morphology 0.0245887578941175 0.113991163389814 1.17235772357724 0.777777777777778 5.1 5 1 multiflagellated sperm 0.0245887578941175 0.113991163389814 1.17235772357724 0.777777777777778 5.1 5 1 retropulsion 0.0245887578941175 0.113991163389814 1.17235772357724 0.777777777777778 5.1 5 1 abnormal heart left ventricle pressure 0.0245887578941175 0.113991163389814 1.17235772357724 0.777777777777778 5.1 5 1 abnormal pulmonary alveolar system morphology 0.0245887578941175 0.113991163389814 1.17235772357724 0.777777777777778 5.1 5 1 trigeminal neuroma 0.0245887578941175 0.113991163389814 1.17235772357724 0.777777777777778 5.1 5 1 abnormal infrahyoid muscle connection 0.0245887578941175 0.113991163389814 1.17235772357724 0.777777777777778 5.1 5 1 abnormal coronary sinus connection 0.0245887578941175 0.113991163389814 1.17235772357724 0.777777777777778 5.1 5 1 decreased platelet dense granule number 0.0245887578941175 0.113991163389814 1.17235772357724 0.777777777777778 5.1 5 1 hyperactivity 3.91176225166948e-50 3.24350286700928e-47 1.17010058510289 0.776280323450135 5.1 5 1 abnormal posture 7.71223048647255e-12 5.3289370375279e-10 1.16817073170732 0.775 5.1 5 1 preaxial polydactyly 2.3659345653433e-05 0.000414455086710666 1.1669551534225 0.774193548387097 5.1 5 1 abnormal nervous system physiology 2.56392683061079e-16 3.27065025186889e-14 1.16653234358431 0.773913043478261 5.1 5 1 abnormal long bone epiphysis morphology 0.000408312151286381 0.0045444137643171 1.16474501108647 0.772727272727273 5.1 5 1 increased coping response 0.000408312151286381 0.0045444137643171 1.16474501108647 0.772727272727273 5.1 5 1 abnormal sperm midpiece morphology 0.000408312151286381 0.0045444137643171 1.16474501108647 0.772727272727273 5.1 5 1 abnormal locomotor behavior 3.40856582265438e-13 2.77993687995173e-11 1.16325556733828 0.771739130434783 5.1 5 1 small liver 2.93553564813492e-11 1.84864428474319e-09 1.15947467166979 0.769230769230769 5.1 5 1 decreased circulating glycerol level 0.00013694484498826 0.00184640166053885 1.15947467166979 0.769230769230769 5.1 5 1 abnormal nerve conduction 0.00013694484498826 0.00184640166053885 1.15947467166979 0.769230769230769 5.1 5 1 absent common myeloid progenitor cells 0.00759604803813154 0.0475948853774615 1.15947467166979 0.769230769230769 5.1 5 1 excessive scratching 0.00759604803813154 0.0475948853774615 1.15947467166979 0.769230769230769 5.1 5 1 abnormal intercostal muscle morphology 0.00759604803813154 0.0475948853774615 1.15947467166979 0.769230769230769 5.1 5 1 abnormal tail bud morphology 0.00759604803813154 0.0475948853774615 1.15947467166979 0.769230769230769 5.1 5 1 abnormal afterhyperpolarization 0.00759604803813154 0.0475948853774615 1.15947467166979 0.769230769230769 5.1 5 1 abnormal retinal inner plexiform layer morphology 0.00759604803813154 0.0475948853774615 1.15947467166979 0.769230769230769 5.1 5 1 increased prostaglandin level 0.00759604803813154 0.0475948853774615 1.15947467166979 0.769230769230769 5.1 5 1 decreased cardiac stroke volume 0.00759604803813154 0.0475948853774615 1.15947467166979 0.769230769230769 5.1 5 1 enhanced long term potentiation 2.08241394647679e-08 7.56205064505259e-07 1.15740418118467 0.767857142857143 5.1 5 1 abnormal vasculogenesis 9.62743182554082e-07 2.38290912099829e-05 1.15677821894498 0.767441860465116 5.1 5 1 abnormal optic cup morphology 4.63641607724384e-05 0.000753796404715298 1.15560975609756 0.766666666666667 5.1 5 1 increased neuron apoptosis 2.00473759511255e-11 1.32980927142466e-09 1.15374887082204 0.765432098765432 5.1 5 1 abnormal bone marrow cavity morphology 0.00243847436776469 0.0195038745653205 1.15265423242468 0.764705882352941 5.1 5 1 increased aggression towards mice 0.00243847436776469 0.0195038745653205 1.15265423242468 0.764705882352941 5.1 5 1 abnormal heart rate 0.00243847436776469 0.0195038745653205 1.15265423242468 0.764705882352941 5.1 5 1 abnormal touch/ nociception 0.00243847436776469 0.0195038745653205 1.15265423242468 0.764705882352941 5.1 5 1 abnormal embryonic-extraembryonic boundary morphology 0.00243847436776469 0.0195038745653205 1.15265423242468 0.764705882352941 5.1 5 1 coloboma 0.00243847436776469 0.0195038745653205 1.15265423242468 0.764705882352941 5.1 5 1 decreased body fat mass 0.00243847436776469 0.0195038745653205 1.15265423242468 0.764705882352941 5.1 5 1 abnormal learning/memory/conditioning 4.03671152198875e-08 1.34782817596604e-06 1.1510421286031 0.763636363636364 5.1 5 1 increased grooming behavior 5.42120373382067e-06 0.000112847232534552 1.15032092426187 0.763157894736842 5.1 5 1 incomplete somite formation 5.42120373382067e-06 0.000112847232534552 1.15032092426187 0.763157894736842 5.1 5 1 left pulmonary isomerism 0.000800913896732671 0.00760394597868981 1.14843205574913 0.761904761904762 5.1 5 1 embryonic lethality at implantation, complete penetrance 0.000800913896732671 0.00760394597868981 1.14843205574913 0.761904761904762 5.1 5 1 absent segment of posterior cerebral artery 0.000800913896732671 0.00760394597868981 1.14843205574913 0.761904761904762 5.1 5 1 decreased vocalization 0.000800913896732671 0.00760394597868981 1.14843205574913 0.761904761904762 5.1 5 1 abnormal forelimb morphology 6.45584611683169e-07 1.6993563191131e-05 1.14687168610817 0.760869565217391 5.1 5 1 abnormal myelin sheath morphology 6.45584611683169e-07 1.6993563191131e-05 1.14687168610817 0.760869565217391 5.1 5 1 embryonic lethality between implantation and placentation, complete penetrance 6.45584611683169e-07 1.6993563191131e-05 1.14687168610817 0.760869565217391 5.1 5 1 increased cellular sensitivity to ionizing radiation 0.000267091573136052 0.00317483933838475 1.14556097560976 0.76 5.1 5 1 abnormal cochlear outer hair cell morphology 0.000267091573136052 0.00317483933838475 1.14556097560976 0.76 5.1 5 1 cochlear ganglion degeneration 2.71224954964808e-08 9.43597308356588e-07 1.1434819175778 0.758620689655172 5.1 5 1 ataxia 2.96830195455533e-25 7.38365111195637e-23 1.1416807534412 0.757425742574257 5.1 5 1 abnormal breathing pattern 1.04658482462543e-05 0.000202597646012121 1.14067237969677 0.756756756756757 5.1 5 1 decreased width of hypertrophic chondrocyte zone 1.04658482462543e-05 0.000202597646012121 1.14067237969677 0.756756756756757 5.1 5 1 abnormal maternal nurturing 1.81210832981842e-08 6.6779547709975e-07 1.13666533386645 0.754098360655738 5.1 5 1 abnormal lung development 3.36073377363583e-11 2.03898177119979e-09 1.13492109038737 0.752941176470588 5.1 5 1 limb grasping 2.51204866743967e-22 5.20726755021348e-20 1.1346287858483 0.752747252747253 5.1 5 1 abnormal social investigation 1.81702030994643e-10 9.61667664040795e-09 1.13048780487805 0.75 5.1 5 1 muscular atrophy 2.37153043452639e-06 5.41209353750861e-05 1.13048780487805 0.75 5.1 5 1 perinatal lethality 6.88010296008622e-06 0.000138018194461407 1.13048780487805 0.75 5.1 5 1 ocular hypertelorism 0.000515241468968373 0.00543077607652045 1.13048780487805 0.75 5.1 5 1 abnormal nursing 0.000515241468968373 0.00543077607652045 1.13048780487805 0.75 5.1 5 1 increased stereotypic behavior 0.000515241468968373 0.00543077607652045 1.13048780487805 0.75 5.1 5 1 abnormal startle reflex 0.000515241468968373 0.00543077607652045 1.13048780487805 0.75 5.1 5 1 abnormal impulse conducting system conduction 0.000515241468968373 0.00543077607652045 1.13048780487805 0.75 5.1 5 1 increased hemangiosarcoma incidence 0.000515241468968373 0.00543077607652045 1.13048780487805 0.75 5.1 5 1 small gonad 0.0015512830865706 0.013515995368982 1.13048780487805 0.75 5.1 5 1 abnormal circulating enzyme level 0.0015512830865706 0.013515995368982 1.13048780487805 0.75 5.1 5 1 increased mammary adenocarcinoma incidence 0.0015512830865706 0.013515995368982 1.13048780487805 0.75 5.1 5 1 abnormal dopamine level 0.0015512830865706 0.013515995368982 1.13048780487805 0.75 5.1 5 1 abnormal sperm mitochondrial sheath morphology 0.0015512830865706 0.013515995368982 1.13048780487805 0.75 5.1 5 1 absent ductus venosus valve 0.0015512830865706 0.013515995368982 1.13048780487805 0.75 5.1 5 1 mesocardia 0.0149282751257031 0.079261652881935 1.13048780487805 0.75 5.1 5 1 abnormal pilomotor reflex 0.0149282751257031 0.079261652881935 1.13048780487805 0.75 5.1 5 1 abnormal thymus involution 0.0149282751257031 0.079261652881935 1.13048780487805 0.75 5.1 5 1 abnormal embryonic growth/weight/body size 0.0149282751257031 0.079261652881935 1.13048780487805 0.75 5.1 5 1 abnormal aorta elastic fiber morphology 0.0149282751257031 0.079261652881935 1.13048780487805 0.75 5.1 5 1 loss of dopaminergic neurons 0.0149282751257031 0.079261652881935 1.13048780487805 0.75 5.1 5 1 dilated bile duct 0.0149282751257031 0.079261652881935 1.13048780487805 0.75 5.1 5 1 increased osteosarcoma incidence 0.0149282751257031 0.079261652881935 1.13048780487805 0.75 5.1 5 1 bowed ulna 0.0149282751257031 0.079261652881935 1.13048780487805 0.75 5.1 5 1 abnormal cochlear outer hair cell physiology 0.0149282751257031 0.079261652881935 1.13048780487805 0.75 5.1 5 1 abnormal amacrine cell morphology 0.0149282751257031 0.079261652881935 1.13048780487805 0.75 5.1 5 1 reduced cerebellar foliation 0.0149282751257031 0.079261652881935 1.13048780487805 0.75 5.1 5 1 prenatal growth retardation 0.0149282751257031 0.079261652881935 1.13048780487805 0.75 5.1 5 1 abnormal vitelline vein connection 0.0149282751257031 0.079261652881935 1.13048780487805 0.75 5.1 5 1 abnormal eating behavior 3.45060473064647e-08 1.17580537910727e-06 1.13048780487805 0.75 5.1 5 1 abnormal pharyngeal arch morphology 2.00463825431359e-05 0.000354913712285058 1.13048780487805 0.75 5.1 5 1 abnormal depression-related behavior 5.87214973963615e-05 0.000907265371263659 1.13048780487805 0.75 5.1 5 1 abnormal auditory brainstem response waveform shape 5.87214973963615e-05 0.000907265371263659 1.13048780487805 0.75 5.1 5 1 absent corpus callosum 0.000173178341873754 0.00222052126500496 1.13048780487805 0.75 5.1 5 1 abnormal hormone level 0.000173178341873754 0.00222052126500496 1.13048780487805 0.75 5.1 5 1 increased bone resorption 0.000173178341873754 0.00222052126500496 1.13048780487805 0.75 5.1 5 1 subcutaneous edema 0.000173178341873754 0.00222052126500496 1.13048780487805 0.75 5.1 5 1 poor circulation 0.00475025365904787 0.0326867385252602 1.13048780487805 0.75 5.1 5 1 white spotting 0.00475025365904787 0.0326867385252602 1.13048780487805 0.75 5.1 5 1 decreased liver cholesterol level 0.00475025365904787 0.0326867385252602 1.13048780487805 0.75 5.1 5 1 embryonic lethality between somite formation and embryo turning, incomplete penetrance 0.00475025365904787 0.0326867385252602 1.13048780487805 0.75 5.1 5 1 decreased fibroblast apoptosis 0.00475025365904787 0.0326867385252602 1.13048780487805 0.75 5.1 5 1 abnormal ear pigmentation 0.0490683423837351 0.187061305256002 1.13048780487805 0.75 5.1 5 1 abnormal bone marrow development 0.0490683423837351 0.187061305256002 1.13048780487805 0.75 5.1 5 1 failure of vascular branching 0.0490683423837351 0.187061305256002 1.13048780487805 0.75 5.1 5 1 absent mammary gland 0.0490683423837351 0.187061305256002 1.13048780487805 0.75 5.1 5 1 abnormal vagus ganglion morphology 0.0490683423837351 0.187061305256002 1.13048780487805 0.75 5.1 5 1 increased sensitivity to skin irradiation 0.0490683423837351 0.187061305256002 1.13048780487805 0.75 5.1 5 1 dermal cysts 0.0490683423837351 0.187061305256002 1.13048780487805 0.75 5.1 5 1 preneoplasia 0.0490683423837351 0.187061305256002 1.13048780487805 0.75 5.1 5 1 abnormal hepatobiliary system morphology 0.0490683423837351 0.187061305256002 1.13048780487805 0.75 5.1 5 1 head spot 0.0490683423837351 0.187061305256002 1.13048780487805 0.75 5.1 5 1 altered response to CNS ischemic injury 0.0490683423837351 0.187061305256002 1.13048780487805 0.75 5.1 5 1 hypospadia 0.0490683423837351 0.187061305256002 1.13048780487805 0.75 5.1 5 1 decreased susceptibility to age related obesity 0.0490683423837351 0.187061305256002 1.13048780487805 0.75 5.1 5 1 liver cysts 0.0490683423837351 0.187061305256002 1.13048780487805 0.75 5.1 5 1 abnormal eyelid aperture 0.0490683423837351 0.187061305256002 1.13048780487805 0.75 5.1 5 1 elevated level of mitotic sister chromatid exchange 0.0490683423837351 0.187061305256002 1.13048780487805 0.75 5.1 5 1 thin stria vascularis 0.0490683423837351 0.187061305256002 1.13048780487805 0.75 5.1 5 1 bowed fibula 0.0490683423837351 0.187061305256002 1.13048780487805 0.75 5.1 5 1 absent interparietal bone 0.0490683423837351 0.187061305256002 1.13048780487805 0.75 5.1 5 1 accumulation of giant lysosomes in kidney/renal tubule cells 0.0490683423837351 0.187061305256002 1.13048780487805 0.75 5.1 5 1 ocular hypertension 0.0490683423837351 0.187061305256002 1.13048780487805 0.75 5.1 5 1 abnormal base-excision repair 0.0490683423837351 0.187061305256002 1.13048780487805 0.75 5.1 5 1 abnormal frontonasal prominence morphology 0.0490683423837351 0.187061305256002 1.13048780487805 0.75 5.1 5 1 abnormal cerebellum deep nucleus morphology 0.0490683423837351 0.187061305256002 1.13048780487805 0.75 5.1 5 1 abnormal brain ependyma morphology 0.0490683423837351 0.187061305256002 1.13048780487805 0.75 5.1 5 1 sinoatrial block 0.0490683423837351 0.187061305256002 1.13048780487805 0.75 5.1 5 1 lung situs inversus 0.0490683423837351 0.187061305256002 1.13048780487805 0.75 5.1 5 1 abnormal maxillary prominence morphology 0.0490683423837351 0.187061305256002 1.13048780487805 0.75 5.1 5 1 abnormal foramen magnum morphology 0.0490683423837351 0.187061305256002 1.13048780487805 0.75 5.1 5 1 impaired neuron differentiation 0.0490683423837351 0.187061305256002 1.13048780487805 0.75 5.1 5 1 abnormal heart echocardiography feature 0.0490683423837351 0.187061305256002 1.13048780487805 0.75 5.1 5 1 prolonged PQ interval 0.0490683423837351 0.187061305256002 1.13048780487805 0.75 5.1 5 1 increased cornea thickness 0.0490683423837351 0.187061305256002 1.13048780487805 0.75 5.1 5 1 increased testis apoptosis 0.0490683423837351 0.187061305256002 1.13048780487805 0.75 5.1 5 1 absent hypoglossal canal 0.0490683423837351 0.187061305256002 1.13048780487805 0.75 5.1 5 1 embryo cyst 0.0490683423837351 0.187061305256002 1.13048780487805 0.75 5.1 5 1 increased brain apoptosis 0.0490683423837351 0.187061305256002 1.13048780487805 0.75 5.1 5 1 decreased basal metabolism 0.0490683423837351 0.187061305256002 1.13048780487805 0.75 5.1 5 1 decreased vascular endothelial cell proliferation 0.0490683423837351 0.187061305256002 1.13048780487805 0.75 5.1 5 1 abnormal motor coordination/ balance 1.8551902152944e-12 1.39841989713479e-10 1.12668144863267 0.747474747474748 5.1 5 1 abnormal neuron morphology 1.8551902152944e-12 1.39841989713479e-10 1.12668144863267 0.747474747474748 5.1 5 1 abnormal behavior 7.46624701682755e-32 2.65318420776551e-29 1.12235479908756 0.744604316546763 5.1 5 1 abnormal liver development 3.80779924135111e-05 0.000633571947348554 1.1197212543554 0.742857142857143 5.1 5 1 abnormal midbrain development 3.80779924135111e-05 0.000633571947348554 1.1197212543554 0.742857142857143 5.1 5 1 impaired behavioral response to xenobiotic 3.80779924135111e-05 0.000633571947348554 1.1197212543554 0.742857142857143 5.1 5 1 pericardial effusion 4.29971014056158e-08 1.42275179822125e-06 1.1183320220299 0.741935483870968 5.1 5 1 abnormal postnatal growth/weight/body size 0.000111640504239579 0.00156895906381894 1.1183320220299 0.741935483870968 5.1 5 1 abnormal capillary morphology 0.000111640504239579 0.00156895906381894 1.1183320220299 0.741935483870968 5.1 5 1 abnormal brain commissure morphology 0.000329618342557123 0.00373542426929769 1.11653116531165 0.740740740740741 5.1 5 1 abnormal eye muscle morphology 0.000329618342557123 0.00373542426929769 1.11653116531165 0.740740740740741 5.1 5 1 impaired coordination 2.94521409044894e-38 1.62804889999816e-35 1.1152403778373 0.739884393063584 5.1 5 1 abnormal cochlear ganglion morphology 0.000982140832657913 0.00903170174209449 1.11410392364793 0.739130434782609 5.1 5 1 abnormal Wolffian duct morphology 0.000982140832657913 0.00903170174209449 1.11410392364793 0.739130434782609 5.1 5 1 pallor 9.35038066846724e-20 1.55060479418748e-17 1.11110801393728 0.737142857142857 5.1 5 1 abnormal reproductive system physiology 2.4590852881068e-05 0.000426270010743251 1.11065468549422 0.736842105263158 5.1 5 1 decreased neuron apoptosis 2.4590852881068e-05 0.000426270010743251 1.11065468549422 0.736842105263158 5.1 5 1 abnormal stationary movement 0.0029629720299857 0.0227130752683804 1.11065468549422 0.736842105263158 5.1 5 1 stereotypic behavior 0.0029629720299857 0.0227130752683804 1.11065468549422 0.736842105263158 5.1 5 1 decreased chemically-elicited antinociception 0.0029629720299857 0.0227130752683804 1.11065468549422 0.736842105263158 5.1 5 1 abnormal behavioral response to xenobiotic 0.0029629720299857 0.0227130752683804 1.11065468549422 0.736842105263158 5.1 5 1 abnormal forebrain development 6.47193286951874e-09 2.63916934638162e-07 1.10955284552846 0.736111111111111 5.1 5 1 atrioventricular septal defect 6.61670551197379e-07 1.72346125246438e-05 1.10915784629544 0.735849056603774 5.1 5 1 abnormal bone remodeling 7.16907366866922e-05 0.00108079216671604 1.10832137733142 0.735294117647059 5.1 5 1 abnormal direction of heart looping 7.16907366866922e-05 0.00108079216671604 1.10832137733142 0.735294117647059 5.1 5 1 interdigital webbing 0.0090990116408973 0.0544081525402212 1.10536585365854 0.733333333333333 5.1 5 1 abnormal prostate gland morphology 0.0090990116408973 0.0544081525402212 1.10536585365854 0.733333333333333 5.1 5 1 hyperpigmentation 0.0090990116408973 0.0544081525402212 1.10536585365854 0.733333333333333 5.1 5 1 absent egg cylinders 0.0090990116408973 0.0544081525402212 1.10536585365854 0.733333333333333 5.1 5 1 dilated ureter 0.0090990116408973 0.0544081525402212 1.10536585365854 0.733333333333333 5.1 5 1 decreased aggression towards males 0.0090990116408973 0.0544081525402212 1.10536585365854 0.733333333333333 5.1 5 1 abnormal cell differentiation 1.58333189485344e-05 0.000290667017597633 1.10291493158834 0.731707317073171 5.1 5 1 preweaning lethality, incomplete penetrance 1.0276251578179e-42 7.30347880020582e-40 1.10192617329596 0.731051344743276 5.1 5 1 abnormal ureter morphology 0.00062034697810863 0.00633722015624319 1.1015009380863 0.730769230769231 5.1 5 1 increased erythroid progenitor cell number 4.59138251447168e-05 0.000748922229819561 1.09993408042189 0.72972972972973 5.1 5 1 abnormal action potential 2.22574470755765e-08 7.96624454683404e-07 1.0981881533101 0.728571428571429 5.1 5 1 decreased circulating total protein level 7.95458340493828e-07 1.9986895171499e-05 1.09623059866962 0.727272727272727 5.1 5 1 decreased blood urea nitrogen level 1.01719061970212e-05 0.000199233202087324 1.09623059866962 0.727272727272727 5.1 5 1 belly spot 0.000133707612814627 0.00182745981800212 1.09623059866962 0.727272727272727 5.1 5 1 abnormal locomotor coordination 0.000133707612814627 0.00182745981800212 1.09623059866962 0.727272727272727 5.1 5 1 decreased cardiac output 0.00184785188458945 0.0155550983516625 1.09623059866962 0.727272727272727 5.1 5 1 cleft upper lip 0.00184785188458945 0.0155550983516625 1.09623059866962 0.727272727272727 5.1 5 1 abnormal occipital bone morphology 0.00184785188458945 0.0155550983516625 1.09623059866962 0.727272727272727 5.1 5 1 premature suture closure 0.0287197160179747 0.127046794601193 1.09623059866962 0.727272727272727 5.1 5 1 abnormal awl hair morphology 0.0287197160179747 0.127046794601193 1.09623059866962 0.727272727272727 5.1 5 1 abnormal eye distance/ position 0.0287197160179747 0.127046794601193 1.09623059866962 0.727272727272727 5.1 5 1 abnormal food preference 0.0287197160179747 0.127046794601193 1.09623059866962 0.727272727272727 5.1 5 1 decreased post-tetanic potentiation 0.0287197160179747 0.127046794601193 1.09623059866962 0.727272727272727 5.1 5 1 abnormal radial glial cell morphology 0.0287197160179747 0.127046794601193 1.09623059866962 0.727272727272727 5.1 5 1 increased circulating triiodothyronine level 0.0287197160179747 0.127046794601193 1.09623059866962 0.727272727272727 5.1 5 1 enhanced behavioral response to addictive substance 0.0287197160179747 0.127046794601193 1.09623059866962 0.727272727272727 5.1 5 1 palatal shelf hypoplasia 0.0287197160179747 0.127046794601193 1.09623059866962 0.727272727272727 5.1 5 1 abnormal pulmonary alveolar sac morphology 0.0287197160179747 0.127046794601193 1.09623059866962 0.727272727272727 5.1 5 1 decreased core body temperature 0.0287197160179747 0.127046794601193 1.09623059866962 0.727272727272727 5.1 5 1 decreased exploration in new environment 1.16848869856611e-09 5.5896454570831e-08 1.09459930313589 0.726190476190476 5.1 5 1 impaired balance 2.19570639191081e-11 1.43732096049424e-09 1.093543758967 0.725490196078431 5.1 5 1 cochlear inner hair cell degeneration 2.2760246737619e-06 5.21807500090574e-05 1.093543758967 0.725490196078431 5.1 5 1 abnormal embryonic neuroepithelium morphology 5.13055204034853e-07 1.38720089134424e-05 1.09150546677881 0.724137931034483 5.1 5 1 neuron degeneration 6.52384146096746e-06 0.000132473923544135 1.09039958484691 0.723404255319149 5.1 5 1 abnormal neural tube closure 2.1427045144087e-09 9.69086814471207e-08 1.08962679988246 0.72289156626506 5.1 5 1 heart right ventricle hypertrophy 8.49601780764866e-05 0.00125873109192849 1.08861788617886 0.722222222222222 5.1 5 1 absent spleen 0.00557210902616927 0.036668310059778 1.08861788617886 0.722222222222222 5.1 5 1 abnormal phrenic nerve morphology 0.00557210902616927 0.036668310059778 1.08861788617886 0.722222222222222 5.1 5 1 abnormal thymus cortex morphology 0.00557210902616927 0.036668310059778 1.08861788617886 0.722222222222222 5.1 5 1 abnormal bile duct morphology 0.00557210902616927 0.036668310059778 1.08861788617886 0.722222222222222 5.1 5 1 increased circulating glycerol level 0.00557210902616927 0.036668310059778 1.08861788617886 0.722222222222222 5.1 5 1 abnormal eye anterior chamber morphology 0.00557210902616927 0.036668310059778 1.08861788617886 0.722222222222222 5.1 5 1 decreased pulmonary respiratory rate 0.00557210902616927 0.036668310059778 1.08861788617886 0.722222222222222 5.1 5 1 atrioventricular block 0.00557210902616927 0.036668310059778 1.08861788617886 0.722222222222222 5.1 5 1 primary atelectasis 0.00557210902616927 0.036668310059778 1.08861788617886 0.722222222222222 5.1 5 1 abnormal aerobic respiration 0.00557210902616927 0.036668310059778 1.08861788617886 0.722222222222222 5.1 5 1 increased adipocyte glucose uptake 0.00557210902616927 0.036668310059778 1.08861788617886 0.722222222222222 5.1 5 1 abnormal cell cycle 2.14377150329957e-12 1.56842106307579e-10 1.08788971367975 0.721739130434783 5.1 5 1 delayed endochondral bone ossification 1.87375108568231e-05 0.000337750422147445 1.08667044809983 0.720930232558139 5.1 5 1 abnormal cell morphology 3.9052560071584e-12 2.73642938529761e-10 1.08421052631579 0.719298245614035 5.1 5 1 scoliosis 0.000246877966172245 0.00298111136336631 1.08338414634146 0.71875 5.1 5 1 bradykinesia 0.000246877966172245 0.00298111136336631 1.08338414634146 0.71875 5.1 5 1 pancreatic islet hyperplasia 0.000246877966172245 0.00298111136336631 1.08338414634146 0.71875 5.1 5 1 absent mesoderm 6.02747492570866e-07 1.62090204083246e-05 1.08024390243902 0.716666666666667 5.1 5 1 lethality throughout fetal growth and development, incomplete penetrance 8.82856284086061e-18 1.15584474034951e-15 1.07785801880365 0.715083798882682 5.1 5 1 abnormal long bone hypertrophic chondrocyte zone 7.61759438562577e-06 0.000151590128273953 1.07665505226481 0.714285714285714 5.1 5 1 domed cranium 8.77469266202658e-08 2.76291746794824e-06 1.07665505226481 0.714285714285714 5.1 5 1 abnormal scapula morphology 0.00342720606116541 0.0256011263578047 1.07665505226481 0.714285714285714 5.1 5 1 abnormal eye pigmentation 0.00342720606116541 0.0256011263578047 1.07665505226481 0.714285714285714 5.1 5 1 trunk curl 0.00342720606116541 0.0256011263578047 1.07665505226481 0.714285714285714 5.1 5 1 liver degeneration 0.00342720606116541 0.0256011263578047 1.07665505226481 0.714285714285714 5.1 5 1 abnormal erythropoiesis 5.56188098257329e-11 3.25533622215319e-09 1.07665505226481 0.714285714285714 5.1 5 1 shortened head 0.000720718344265545 0.00703053678964919 1.07665505226481 0.714285714285714 5.1 5 1 abnormal ovulation 0.000720718344265545 0.00703053678964919 1.07665505226481 0.714285714285714 5.1 5 1 abnormal interparietal bone morphology 0.0170974454597921 0.0891612066692511 1.07665505226481 0.714285714285714 5.1 5 1 midline facial cleft 0.0170974454597921 0.0891612066692511 1.07665505226481 0.714285714285714 5.1 5 1 megacephaly 0.0170974454597921 0.0891612066692511 1.07665505226481 0.714285714285714 5.1 5 1 increased aggression towards males 0.0170974454597921 0.0891612066692511 1.07665505226481 0.714285714285714 5.1 5 1 abnormal placing response 0.0170974454597921 0.0891612066692511 1.07665505226481 0.714285714285714 5.1 5 1 abnormal adrenal gland secretion 0.0170974454597921 0.0891612066692511 1.07665505226481 0.714285714285714 5.1 5 1 failure of zygotic cell division 0.0170974454597921 0.0891612066692511 1.07665505226481 0.714285714285714 5.1 5 1 abnormal vascular endothelial cell migration 0.0170974454597921 0.0891612066692511 1.07665505226481 0.714285714285714 5.1 5 1 decreased tongue size 0.0170974454597921 0.0891612066692511 1.07665505226481 0.714285714285714 5.1 5 1 abnormal renal tubule epithelial cell primary cilium morphology 0.0170974454597921 0.0891612066692511 1.07665505226481 0.714285714285714 5.1 5 1 failure of atrioventricular cushion closure 0.0951080607321568 0.281411926734436 1.07665505226481 0.714285714285714 5.1 5 1 maxilla hypoplasia 0.0951080607321568 0.281411926734436 1.07665505226481 0.714285714285714 5.1 5 1 small L4 dorsal root ganglion 0.0951080607321568 0.281411926734436 1.07665505226481 0.714285714285714 5.1 5 1 absent epidermis stratum corneum 0.0951080607321568 0.281411926734436 1.07665505226481 0.714285714285714 5.1 5 1 limp posture 0.0951080607321568 0.281411926734436 1.07665505226481 0.714285714285714 5.1 5 1 increased chemically-elicited antinociception 0.0951080607321568 0.281411926734436 1.07665505226481 0.714285714285714 5.1 5 1 abnormal tumor incidence 0.0951080607321568 0.281411926734436 1.07665505226481 0.714285714285714 5.1 5 1 abnormal gastrulation movements 0.0951080607321568 0.281411926734436 1.07665505226481 0.714285714285714 5.1 5 1 abnormal inhibitory postsynaptic potential 0.0951080607321568 0.281411926734436 1.07665505226481 0.714285714285714 5.1 5 1 increased retinal ganglion cell number 0.0951080607321568 0.281411926734436 1.07665505226481 0.714285714285714 5.1 5 1 decreased urine calcium level 0.0951080607321568 0.281411926734436 1.07665505226481 0.714285714285714 5.1 5 1 detached tectorial membrane 0.0951080607321568 0.281411926734436 1.07665505226481 0.714285714285714 5.1 5 1 decreased cholesterol efflux 0.0951080607321568 0.281411926734436 1.07665505226481 0.714285714285714 5.1 5 1 aorta coarctation 0.0951080607321568 0.281411926734436 1.07665505226481 0.714285714285714 5.1 5 1 increased cell nucleus count 0.0951080607321568 0.281411926734436 1.07665505226481 0.714285714285714 5.1 5 1 absent deltoid tuberosity 0.0951080607321568 0.281411926734436 1.07665505226481 0.714285714285714 5.1 5 1 absent ulna 0.0951080607321568 0.281411926734436 1.07665505226481 0.714285714285714 5.1 5 1 abnormal strial marginal cell morphology 0.0951080607321568 0.281411926734436 1.07665505226481 0.714285714285714 5.1 5 1 absent endocochlear potential 0.0951080607321568 0.281411926734436 1.07665505226481 0.714285714285714 5.1 5 1 abnormal cochlear nerve compound action potential 0.0951080607321568 0.281411926734436 1.07665505226481 0.714285714285714 5.1 5 1 decreased adrenocorticotropin level 0.0951080607321568 0.281411926734436 1.07665505226481 0.714285714285714 5.1 5 1 increased thyroid-stimulating hormone level 0.0951080607321568 0.281411926734436 1.07665505226481 0.714285714285714 5.1 5 1 absent fibula 0.0951080607321568 0.281411926734436 1.07665505226481 0.714285714285714 5.1 5 1 abnormal renal/urinary system physiology 0.0951080607321568 0.281411926734436 1.07665505226481 0.714285714285714 5.1 5 1 decreased tidal volume 0.0951080607321568 0.281411926734436 1.07665505226481 0.714285714285714 5.1 5 1 heart hemorrhage 0.0951080607321568 0.281411926734436 1.07665505226481 0.714285714285714 5.1 5 1 enhanced behavioral response to alcohol 0.0951080607321568 0.281411926734436 1.07665505226481 0.714285714285714 5.1 5 1 decreased behavioral withdrawal response 0.0951080607321568 0.281411926734436 1.07665505226481 0.714285714285714 5.1 5 1 increased oligodendrocyte number 0.0951080607321568 0.281411926734436 1.07665505226481 0.714285714285714 5.1 5 1 decreased brain cholesterol level 0.0951080607321568 0.281411926734436 1.07665505226481 0.714285714285714 5.1 5 1 focal dorsal hair loss 0.0951080607321568 0.281411926734436 1.07665505226481 0.714285714285714 5.1 5 1 abnormal T wave 0.0951080607321568 0.281411926734436 1.07665505226481 0.714285714285714 5.1 5 1 long stride length 0.0951080607321568 0.281411926734436 1.07665505226481 0.714285714285714 5.1 5 1 thick mitral valve cusps 0.0951080607321568 0.281411926734436 1.07665505226481 0.714285714285714 5.1 5 1 altered tumor pathology 0.0951080607321568 0.281411926734436 1.07665505226481 0.714285714285714 5.1 5 1 abnormal impulsive behavior control 0.0951080607321568 0.281411926734436 1.07665505226481 0.714285714285714 5.1 5 1 embryonic lethality at implantation, incomplete penetrance 0.0951080607321568 0.281411926734436 1.07665505226481 0.714285714285714 5.1 5 1 small tail bud 0.0951080607321568 0.281411926734436 1.07665505226481 0.714285714285714 5.1 5 1 impaired mammary gland growth during pregnancy 0.0951080607321568 0.281411926734436 1.07665505226481 0.714285714285714 5.1 5 1 decreased areal bone mineral density 0.0951080607321568 0.281411926734436 1.07665505226481 0.714285714285714 5.1 5 1 decreased femur compact bone thickness 0.0951080607321568 0.281411926734436 1.07665505226481 0.714285714285714 5.1 5 1 decreased collagen level 0.0951080607321568 0.281411926734436 1.07665505226481 0.714285714285714 5.1 5 1 impaired swimming 2.47481868755986e-07 6.95605817548604e-06 1.07339246119734 0.712121212121212 5.1 5 1 abnormal gait 4.5170136470004e-29 1.32189075846041e-26 1.07317073170732 0.711974110032362 5.1 5 1 kinked neural tube 4.8532281739568e-06 0.000102308517650149 1.07251407129456 0.711538461538462 5.1 5 1 lethality at weaning, complete penetrance 2.17230647687161e-05 0.000383234919235328 1.07186991869919 0.711111111111111 5.1 5 1 persistence of hyaloid vascular system 9.82520297918541e-05 0.00140460875923699 1.07098844672657 0.710526315789474 5.1 5 1 decreased total retina thickness 9.82520297918541e-05 0.00140460875923699 1.07098844672657 0.710526315789474 5.1 5 1 infertility 6.45906668044736e-11 3.69354675117536e-09 1.07061773421473 0.710280373831776 5.1 5 1 abnormal embryo turning 3.09106846093151e-06 6.8044538022718e-05 1.06882483370288 0.709090909090909 5.1 5 1 abnormal nervous system morphology 2.315427831999e-08 8.22803818871072e-07 1.06847792528558 0.708860759493671 5.1 5 1 overriding aortic valve 1.37829061279951e-05 0.000259734689343846 1.06768292682927 0.708333333333333 5.1 5 1 decreased metastatic potential 0.00211603928733251 0.0172296161284439 1.06768292682927 0.708333333333333 5.1 5 1 abnormal sensory capabilities/reflexes/nociception 0.00211603928733251 0.0172296161284439 1.06768292682927 0.708333333333333 5.1 5 1 abnormal retinal ganglion layer morphology 0.00211603928733251 0.0172296161284439 1.06768292682927 0.708333333333333 5.1 5 1 abnormal digit morphology 1.01394367701148e-07 3.15273112070758e-06 1.06768292682927 0.708333333333333 5.1 5 1 abnormal brain morphology 1.71610161093707e-15 1.94036488963907e-13 1.06729283441903 0.708074534161491 5.1 5 1 lethality at weaning, incomplete penetrance 6.20164995845002e-05 0.00095161294635873 1.0661511005354 0.707317073170732 5.1 5 1 abnormal spermiogenesis 1.96833075946593e-06 4.59739226682771e-05 1.06551724137931 0.706896551724138 5.1 5 1 abnormal ductus venosus valve morphology 0.0102985239581275 0.0602766549313934 1.06398852223816 0.705882352941177 5.1 5 1 reduced fertility 2.45278929856808e-13 2.03377112672937e-11 1.06271275662397 0.705035971223022 5.1 5 1 embryonic lethality, incomplete penetrance 3.91631835071201e-05 0.000649456126493076 1.0619733924612 0.704545454545455 5.1 5 1 increased cell proliferation 5.54965372133752e-06 0.000114562353791096 1.06070460704607 0.703703703703704 5.1 5 1 decreased tumor growth/size 5.54965372133752e-06 0.000114562353791096 1.06070460704607 0.703703703703704 5.1 5 1 thick interventricular septum 0.00131082748754346 0.0115832446723423 1.06070460704607 0.703703703703704 5.1 5 1 abnormal locomotor activation 3.89631879119976e-09 1.64272762595075e-07 1.06009112838381 0.703296703296703 5.1 5 1 abnormal innervation 2.47438409960415e-05 0.000427432669983703 1.058329008822 0.702127659574468 5.1 5 1 absent vitelline blood vessels 3.52225339655829e-06 7.68561870520944e-05 1.05776636713736 0.701754385964912 5.1 5 1 prenatal lethality, complete penetrance 1.21598248463453e-24 2.88072041002704e-22 1.05729075276364 0.701438848920863 5.1 5 1 increased B cell derived lymphoma incidence 1.56414966074722e-05 0.00028928046699693 1.05512195121951 0.7 5.1 5 1 decreased oocyte number 1.56414966074722e-05 0.00028928046699693 1.05512195121951 0.7 5.1 5 1 abnormal response to new environment 0.000814348480985698 0.00764460713568019 1.05512195121951 0.7 5.1 5 1 abnormal vascular regression 0.0062569128979543 0.0403737246009373 1.05512195121951 0.7 5.1 5 1 abnormal lens epithelium morphology 0.0062569128979543 0.0403737246009373 1.05512195121951 0.7 5.1 5 1 abnormal heart right ventricle morphology 0.0062569128979543 0.0403737246009373 1.05512195121951 0.7 5.1 5 1 fused cornea and lens 0.0538733134569294 0.199123131090805 1.05512195121951 0.7 5.1 5 1 absent trophoblast giant cells 0.0538733134569294 0.199123131090805 1.05512195121951 0.7 5.1 5 1 abnormal pituitary secretion 0.0538733134569294 0.199123131090805 1.05512195121951 0.7 5.1 5 1 ketoaciduria 0.0538733134569294 0.199123131090805 1.05512195121951 0.7 5.1 5 1 abnormal PNS synaptic transmission 0.0538733134569294 0.199123131090805 1.05512195121951 0.7 5.1 5 1 abnormal bone healing 0.0538733134569294 0.199123131090805 1.05512195121951 0.7 5.1 5 1 acrania 0.0538733134569294 0.199123131090805 1.05512195121951 0.7 5.1 5 1 abnormal scala media morphology 0.0538733134569294 0.199123131090805 1.05512195121951 0.7 5.1 5 1 peritoneal inflammation 0.0538733134569294 0.199123131090805 1.05512195121951 0.7 5.1 5 1 bifid ureter 0.0538733134569294 0.199123131090805 1.05512195121951 0.7 5.1 5 1 cochlear ganglion hypoplasia 0.0538733134569294 0.199123131090805 1.05512195121951 0.7 5.1 5 1 absent pharyngeal arches 0.0538733134569294 0.199123131090805 1.05512195121951 0.7 5.1 5 1 abnormal ear physiology 0.0538733134569294 0.199123131090805 1.05512195121951 0.7 5.1 5 1 abnormal cochlear inner hair cell physiology 0.0538733134569294 0.199123131090805 1.05512195121951 0.7 5.1 5 1 decreased thyroxine level 0.0538733134569294 0.199123131090805 1.05512195121951 0.7 5.1 5 1 vascular smooth muscle hyperplasia 0.0538733134569294 0.199123131090805 1.05512195121951 0.7 5.1 5 1 abnormal spinal cord dorsal column morphology 0.0538733134569294 0.199123131090805 1.05512195121951 0.7 5.1 5 1 ventricular premature beat 0.0538733134569294 0.199123131090805 1.05512195121951 0.7 5.1 5 1 abnormal hippocampus neuron morphology 0.0538733134569294 0.199123131090805 1.05512195121951 0.7 5.1 5 1 increased circulating fructosamine level 0.0538733134569294 0.199123131090805 1.05512195121951 0.7 5.1 5 1 increased kidney iron level 0.0538733134569294 0.199123131090805 1.05512195121951 0.7 5.1 5 1 fusion of atlas and odontoid process 0.0538733134569294 0.199123131090805 1.05512195121951 0.7 5.1 5 1 abnormal circadian temperature homeostasis 0.0538733134569294 0.199123131090805 1.05512195121951 0.7 5.1 5 1 abnormal craniofacial morphology 6.53095777671273e-10 3.18544264109273e-08 1.05365853658537 0.699029126213592 5.1 5 1 increased cardiomyocyte apoptosis 0.000507169778894769 0.00543077607652045 1.05055432372506 0.696969696969697 5.1 5 1 single kidney 0.000507169778894769 0.00543077607652045 1.05055432372506 0.696969696969697 5.1 5 1 increased startle reflex 1.2246807334712e-08 4.83554495953906e-07 1.05004110715264 0.696629213483146 5.1 5 1 abnormal sleep pattern 4.40590405485656e-05 0.000723411639370013 1.04856839872747 0.695652173913043 5.1 5 1 abnormal allantois morphology 4.40590405485656e-05 0.000723411639370013 1.04856839872747 0.695652173913043 5.1 5 1 abnormal carpal bone morphology 0.00382662000329011 0.0277109672727341 1.04856839872747 0.695652173913043 5.1 5 1 abnormal nasal cavity morphology 0.00382662000329011 0.0277109672727341 1.04856839872747 0.695652173913043 5.1 5 1 abnormal basicranium morphology 0.00382662000329011 0.0277109672727341 1.04856839872747 0.695652173913043 5.1 5 1 abnormal hematopoietic stem cell physiology 0.00382662000329011 0.0277109672727341 1.04856839872747 0.695652173913043 5.1 5 1 hydroencephaly 1.09215437556002e-10 6.03718668712343e-09 1.04856839872747 0.695652173913043 5.1 5 1 abnormal vitelline vasculature morphology 1.09215437556002e-10 6.03718668712343e-09 1.04856839872747 0.695652173913043 5.1 5 1 abnormal reflex 0.000316546277581365 0.00362027064590182 1.04674796747967 0.694444444444444 5.1 5 1 abnormal trophoblast giant cell morphology 0.000316546277581365 0.00362027064590182 1.04674796747967 0.694444444444444 5.1 5 1 abnormal limb morphology 2.31213910353814e-07 6.53573411369446e-06 1.04507317073171 0.693333333333333 5.1 5 1 embryonic lethality, complete penetrance 1.48602629348981e-26 4.10721156117323e-24 1.04425414787063 0.692789968652038 5.1 5 1 abnormal placenta vasculature 1.75027537352458e-05 0.000316640726664901 1.04352720450281 0.692307692307692 5.1 5 1 abnormal nasal bone morphology 0.00235257820285861 0.0190310187954823 1.04352720450281 0.692307692307692 5.1 5 1 no spontaneous movement 0.00235257820285861 0.0190310187954823 1.04352720450281 0.692307692307692 5.1 5 1 short premaxilla 0.0314257860727392 0.136069004100851 1.04352720450281 0.692307692307692 5.1 5 1 absent teeth 0.0314257860727392 0.136069004100851 1.04352720450281 0.692307692307692 5.1 5 1 absent myocardial trabeculae 0.0314257860727392 0.136069004100851 1.04352720450281 0.692307692307692 5.1 5 1 uterus hypoplasia 0.0314257860727392 0.136069004100851 1.04352720450281 0.692307692307692 5.1 5 1 lymphoid hypoplasia 0.0314257860727392 0.136069004100851 1.04352720450281 0.692307692307692 5.1 5 1 abnormal coping response 0.0314257860727392 0.136069004100851 1.04352720450281 0.692307692307692 5.1 5 1 abnormal insulin secretion 0.0314257860727392 0.136069004100851 1.04352720450281 0.692307692307692 5.1 5 1 vestibular hair cell degeneration 0.0314257860727392 0.136069004100851 1.04352720450281 0.692307692307692 5.1 5 1 small interparietal bone 0.0314257860727392 0.136069004100851 1.04352720450281 0.692307692307692 5.1 5 1 increased cochlear inner hair cell number 0.0314257860727392 0.136069004100851 1.04352720450281 0.692307692307692 5.1 5 1 decreased endocochlear potential 0.0314257860727392 0.136069004100851 1.04352720450281 0.692307692307692 5.1 5 1 increased circulating thyroxine level 0.0314257860727392 0.136069004100851 1.04352720450281 0.692307692307692 5.1 5 1 orthokeratosis 0.0314257860727392 0.136069004100851 1.04352720450281 0.692307692307692 5.1 5 1 decreased mean corpuscular hemoglobin 1.00808994211175e-06 2.48279577327027e-05 1.04182209469154 0.691176470588235 5.1 5 1 increased sensitivity to xenobiotic induced morbidity/mortality 5.26500072853883e-10 2.61933786244807e-08 1.04141906873614 0.690909090909091 5.1 5 1 disheveled coat 0.00012398962893674 0.0017182406795551 1.04076655052265 0.69047619047619 5.1 5 1 spina bifida 0.00012398962893674 0.0017182406795551 1.04076655052265 0.69047619047619 5.1 5 1 abnormal embryo size 3.35887376393429e-10 1.7406663516222e-08 1.0404489531621 0.690265486725664 5.1 5 1 abnormal embryonic erythropoiesis 0.00145250908252106 0.0127897923637916 1.03952901597981 0.689655172413793 5.1 5 1 blood in lymph vessels 0.00145250908252106 0.0127897923637916 1.03952901597981 0.689655172413793 5.1 5 1 kidney cysts 4.05523994577615e-07 1.11463086907383e-05 1.03882663150956 0.689189189189189 5.1 5 1 abnormal definitive hematopoiesis 1.52909129763048e-08 5.91188461373125e-07 1.03729346970889 0.688172043010753 5.1 5 1 small heart 4.88578977057439e-05 0.000786627964679856 1.03628048780488 0.6875 5.1 5 1 vertebral transformation 4.88578977057439e-05 0.000786627964679856 1.03628048780488 0.6875 5.1 5 1 abnormal phalanx morphology 4.88578977057439e-05 0.000786627964679856 1.03628048780488 0.6875 5.1 5 1 kidney cortex cysts 0.000899958371620262 0.00835315839330374 1.03628048780488 0.6875 5.1 5 1 failure of primitive streak formation 0.000899958371620262 0.00835315839330374 1.03628048780488 0.6875 5.1 5 1 failure of tooth eruption 0.0186662792009661 0.0939919764749542 1.03628048780488 0.6875 5.1 5 1 disorganized retinal layers 0.0186662792009661 0.0939919764749542 1.03628048780488 0.6875 5.1 5 1 increased intestinal adenocarcinoma incidence 0.0186662792009661 0.0939919764749542 1.03628048780488 0.6875 5.1 5 1 abnormal epididymis epithelium morphology 0.0186662792009661 0.0939919764749542 1.03628048780488 0.6875 5.1 5 1 impaired somite development 0.0186662792009661 0.0939919764749542 1.03628048780488 0.6875 5.1 5 1 abnormal thoracic cage shape 0.0186662792009661 0.0939919764749542 1.03628048780488 0.6875 5.1 5 1 decreased midbrain size 0.0186662792009661 0.0939919764749542 1.03628048780488 0.6875 5.1 5 1 pale yolk sac 1.03726415502474e-07 3.20521066537147e-06 1.03514545988833 0.686746987951807 5.1 5 1 decreased white adipose tissue amount 1.76372034206997e-06 4.17833747704672e-05 1.03487440844558 0.686567164179104 5.1 5 1 abnormal gluconeogenesis 3.07267300626121e-05 0.000525310934919227 1.03443328550933 0.686274509803922 5.1 5 1 edema 2.20095692034622e-14 1.99086557794954e-12 1.03408961996597 0.686046511627907 5.1 5 1 ovary cysts 0.000559258336944279 0.00582073269099955 1.03358885017422 0.685714285714286 5.1 5 1 increased carcinoma incidence 0.000559258336944279 0.00582073269099955 1.03358885017422 0.685714285714286 5.1 5 1 abnormal embryonic epiblast morphology 0.000559258336944279 0.00582073269099955 1.03358885017422 0.685714285714286 5.1 5 1 decreased total body fat amount 1.81985434946518e-26 4.76514494136277e-24 1.03345990944939 0.68562874251497 5.1 5 1 impaired glucose tolerance 5.20153425663702e-20 9.24201175956041e-18 1.03324154209284 0.685483870967742 5.1 5 1 abnormal neural tube morphology 1.46533091787944e-13 1.23559683329664e-11 1.03279132791328 0.685185185185185 5.1 5 1 abnormal maxilla morphology 1.93448100126527e-05 0.000344947777107337 1.03279132791328 0.685185185185185 5.1 5 1 neurodegeneration 1.93448100126527e-05 0.000344947777107337 1.03279132791328 0.685185185185185 5.1 5 1 abnormal neuronal precursor proliferation 1.93448100126527e-05 0.000344947777107337 1.03279132791328 0.685185185185185 5.1 5 1 decreased grip strength 8.81662773473453e-18 1.15584474034951e-15 1.03240895422653 0.684931506849315 5.1 5 1 seminiferous tubule degeneration 7.07192345988869e-07 1.80424713912545e-05 1.03240895422653 0.684931506849315 5.1 5 1 astrocytosis 7.07192345988869e-07 1.80424713912545e-05 1.03240895422653 0.684931506849315 5.1 5 1 hypoactivity 1.93490993514186e-29 6.01636057958172e-27 1.03153263893382 0.684350132625995 5.1 5 1 lethality throughout fetal growth and development, complete penetrance 1.49356224032477e-15 1.76916003467041e-13 1.03132220795892 0.684210526315789 5.1 5 1 impaired righting response 1.69081498229052e-08 6.32466506533483e-07 1.03132220795892 0.684210526315789 5.1 5 1 abnormal frontal bone morphology 0.00034841720160674 0.00391281168847299 1.03132220795892 0.684210526315789 5.1 5 1 impaired branching involved in ureteric bud morphogenesis 0.00034841720160674 0.00391281168847299 1.03132220795892 0.684210526315789 5.1 5 1 enlarged adrenal glands 0.011225239184567 0.0645613467551686 1.03132220795892 0.684210526315789 5.1 5 1 unresponsive to tactile stimuli 0.011225239184567 0.0645613467551686 1.03132220795892 0.684210526315789 5.1 5 1 abnormal long term depression 0.011225239184567 0.0645613467551686 1.03132220795892 0.684210526315789 5.1 5 1 increased malignant tumor incidence 0.011225239184567 0.0645613467551686 1.03132220795892 0.684210526315789 5.1 5 1 abnormal ear morphology 0.011225239184567 0.0645613467551686 1.03132220795892 0.684210526315789 5.1 5 1 abnormal neurotransmitter level 0.011225239184567 0.0645613467551686 1.03132220795892 0.684210526315789 5.1 5 1 abnormal sternebra morphology 0.011225239184567 0.0645613467551686 1.03132220795892 0.684210526315789 5.1 5 1 abnormal cochlear inner hair cell morphology 0.011225239184567 0.0645613467551686 1.03132220795892 0.684210526315789 5.1 5 1 Leydig cell hypoplasia 0.011225239184567 0.0645613467551686 1.03132220795892 0.684210526315789 5.1 5 1 shortened RR interval 0.011225239184567 0.0645613467551686 1.03132220795892 0.684210526315789 5.1 5 1 right-sided stomach 0.011225239184567 0.0645613467551686 1.03132220795892 0.684210526315789 5.1 5 1 abnormal craniofacial bone morphology 1.21908634082379e-05 0.000232373737379248 1.03132220795892 0.684210526315789 5.1 5 1 decreased brain weight 1.21908634082379e-05 0.000232373737379248 1.03132220795892 0.684210526315789 5.1 5 1 decreased startle reflex 4.12652311329232e-10 2.09484209067646e-08 1.03064415259537 0.683760683760684 5.1 5 1 Leydig cell hyperplasia 0.000217536833004878 0.00265941984581396 1.02938726948245 0.682926829268293 5.1 5 1 palatal shelves fail to meet at midline 0.000217536833004878 0.00265941984581396 1.02938726948245 0.682926829268293 5.1 5 1 preweaning lethality, complete penetrance 6.10943418575336e-56 1.0131478358041e-52 1.02864205669084 0.682432432432432 5.1 5 1 double outlet right ventricle 2.76607299075436e-09 1.21780647159318e-07 1.02835650786414 0.682242990654206 5.1 5 1 cochlear hair cell degeneration 0.000136078569266755 0.00184640166053885 1.02771618625277 0.681818181818182 5.1 5 1 abnormal tail movements 0.00681153643954242 0.0435570614225238 1.02771618625277 0.681818181818182 5.1 5 1 aphakia 0.00681153643954242 0.0435570614225238 1.02771618625277 0.681818181818182 5.1 5 1 increased mammary gland tumor incidence 0.00681153643954242 0.0435570614225238 1.02771618625277 0.681818181818182 5.1 5 1 increased bone volume 0.00681153643954242 0.0435570614225238 1.02771618625277 0.681818181818182 5.1 5 1 embryonic lethality between implantation and somite formation, complete penetrance 2.68789724331686e-19 4.05220872287921e-17 1.02743653558985 0.681632653061224 5.1 5 1 perinatal lethality, incomplete penetrance 6.85043534252147e-18 9.46692106362342e-16 1.02710986401899 0.68141592920354 5.1 5 1 decreased cell proliferation 6.97206422148888e-15 6.67038836575138e-13 1.02660514172709 0.681081081081081 5.1 5 1 prenatal lethality, incomplete penetrance 1.77526474938083e-23 4.01451914916802e-21 1.02636392811297 0.680921052631579 5.1 5 1 pulmonary hypoplasia 8.52647995939496e-05 0.00125873109192849 1.02625843279709 0.680851063829787 5.1 5 1 increased cellular sensitivity to gamma-irradiation 8.52647995939496e-05 0.00125873109192849 1.02625843279709 0.680851063829787 5.1 5 1 abnormal neuromuscular synapse morphology 1.22602378931004e-06 2.97535041552072e-05 1.02581300813008 0.680555555555556 5.1 5 1 cochlear outer hair cell degeneration 1.22602378931004e-06 2.97535041552072e-05 1.02581300813008 0.680555555555556 5.1 5 1 abnormal energy expenditure 0.00416177272055826 0.0292854586771957 1.0249756097561 0.68 5.1 5 1 impaired conditioned place preference behavior 0.00416177272055826 0.0292854586771957 1.0249756097561 0.68 5.1 5 1 abnormal bone structure 3.11325500968291e-15 3.3670529724288e-13 1.02310122583091 0.678756476683938 5.1 5 1 abnormal coat/hair pigmentation 1.92851278755273e-09 8.8021569890595e-08 1.02282229965157 0.678571428571429 5.1 5 1 small superior cervical ganglion 0.00255661345668572 0.0202658627678695 1.02282229965157 0.678571428571429 5.1 5 1 abnormal somite shape 0.00255661345668572 0.0202658627678695 1.02282229965157 0.678571428571429 5.1 5 1 straub tail 0.00255661345668572 0.0202658627678695 1.02282229965157 0.678571428571429 5.1 5 1 premature aging 0.00255661345668572 0.0202658627678695 1.02282229965157 0.678571428571429 5.1 5 1 hypoxia 0.00255661345668572 0.0202658627678695 1.02282229965157 0.678571428571429 5.1 5 1 syndactyly 1.3317707791207e-05 0.000251922419244315 1.02190988011575 0.677966101694915 5.1 5 1 pale kidney 0.00157745254601869 0.0137199762525227 1.02108575924469 0.67741935483871 5.1 5 1 pericardial edema 3.34367481470988e-06 7.32809788686416e-05 1.01965566714491 0.676470588235294 5.1 5 1 abnormal skeletal muscle fiber morphology 2.1126077726315e-06 4.86584429113043e-05 1.01903126073514 0.676056338028169 5.1 5 1 short snout 5.20316541554932e-09 2.15714566186316e-07 1.01883468834688 0.675925925925926 5.1 5 1 decreased embryo size 7.47412975561208e-35 3.38034504856092e-32 1.01854270843964 0.675732217573222 5.1 5 1 abnormal branching of the mammary ductal tree 0.000606743610597968 0.00623667244364647 1.01845748187212 0.675675675675676 5.1 5 1 abnormal vocalization 0.000606743610597968 0.00623667244364647 1.01845748187212 0.675675675675676 5.1 5 1 increased circulating phosphate level 0.000606743610597968 0.00623667244364647 1.01845748187212 0.675675675675676 5.1 5 1 decreased erythrocyte cell number 2.20881393531409e-12 1.59258685915762e-10 1.01767904303247 0.67515923566879 5.1 5 1 abnormal muscle physiology 1.36028604733683e-07 4.07676089487995e-06 1.01616881337353 0.674157303370786 5.1 5 1 abnormal cell death 0.000147471790007011 0.00193884162402696 1.01580063626723 0.673913043478261 5.1 5 1 organ of Corti degeneration 9.2377235439273e-05 0.00133597891369297 1.01513190642111 0.673469387755102 5.1 5 1 increased circulating alkaline phosphatase level 1.52875596518679e-12 1.18836889481317e-10 1.01418247515809 0.672839506172839 5.1 5 1 embryonic lethality between somite formation and embryo turning, complete penetrance 3.61752771270666e-06 7.8590394631946e-05 1.01205574912892 0.671428571428571 5.1 5 1 decreased body size 2.19651915259752e-55 2.73192069604316e-52 1.01054465431872 0.670426065162907 5.1 5 1 embryonic lethality during organogenesis, complete penetrance 6.42515610491452e-39 3.99564395274372e-36 1.00936411149826 0.669642857142857 5.1 5 1 abnormal embryo development 1.63125424944202e-10 8.72633321610115e-09 1.00857245337159 0.669117647058823 5.1 5 1 ventricular septal defect 1.63125424944202e-10 8.72633321610115e-09 1.00857245337159 0.669117647058823 5.1 5 1 increased anxiety-related response 1.03810060732344e-10 5.86880741072056e-09 1.00849271802071 0.669064748201439 5.1 5 1 abnormal spermatogenesis 1.19483954823364e-13 1.02488392283834e-11 1.00760869565217 0.668478260869565 5.1 5 1 decreased body length 1.61867360828042e-19 2.59771006490164e-17 1.00671176784761 0.667883211678832 5.1 5 1 increased mean corpuscular hemoglobin 6.35866202230903e-08 2.04092539103145e-06 1.00487804878049 0.666666666666667 5.1 5 1 decreased insulin secretion 2.4939024090495e-07 6.97031712641645e-06 1.00487804878049 0.666666666666667 5.1 5 1 irregular heartbeat 0.000252674529230236 0.00303636662541165 1.00487804878049 0.666666666666667 5.1 5 1 increased circulating corticosterone level 0.000252674529230236 0.00303636662541165 1.00487804878049 0.666666666666667 5.1 5 1 delayed bone ossification 2.45513838718058e-06 5.57731208959973e-05 1.00487804878049 0.666666666666667 5.1 5 1 hydrops fetalis 3.8857757392745e-06 8.3687161484375e-05 1.00487804878049 0.666666666666667 5.1 5 1 gliosis 1.54759053570211e-05 0.000288361906933259 1.00487804878049 0.666666666666667 5.1 5 1 abnormal cochlea morphology 6.21656698626306e-05 0.00095161294635873 1.00487804878049 0.666666666666667 5.1 5 1 abnormal apoptosis 6.21656698626306e-05 0.00095161294635873 1.00487804878049 0.666666666666667 5.1 5 1 oligodactyly 0.000158078603370365 0.00206414974217208 1.00487804878049 0.666666666666667 5.1 5 1 abnormal iris morphology 0.000649359569070059 0.00651323358089424 1.00487804878049 0.666666666666667 5.1 5 1 abnormal lysosome morphology 0.00104468245567011 0.00958910556634465 1.00487804878049 0.666666666666667 5.1 5 1 abnormal tooth development 0.00168553555707124 0.0143834294964484 1.00487804878049 0.666666666666667 5.1 5 1 dextrocardia 0.00168553555707124 0.0143834294964484 1.00487804878049 0.666666666666667 5.1 5 1 abnormal heart tube morphology 0.00272883028559178 0.0212205566927153 1.00487804878049 0.666666666666667 5.1 5 1 abnormal lactation 0.00272883028559178 0.0212205566927153 1.00487804878049 0.666666666666667 5.1 5 1 abnormal brain vasculature morphology 0.00272883028559178 0.0212205566927153 1.00487804878049 0.666666666666667 5.1 5 1 abnormal atrioventricular cushion morphology 0.00443607963348894 0.0309530100653681 1.00487804878049 0.666666666666667 5.1 5 1 rectal prolapse 0.00443607963348894 0.0309530100653681 1.00487804878049 0.666666666666667 5.1 5 1 abnormal single cell response 0.00443607963348894 0.0309530100653681 1.00487804878049 0.666666666666667 5.1 5 1 decreased circulating fructosamine level 0.00443607963348894 0.0309530100653681 1.00487804878049 0.666666666666667 5.1 5 1 decreased body height 0.00724778143520531 0.0460507185697911 1.00487804878049 0.666666666666667 5.1 5 1 abnormal cardiac muscle contractility 0.00724778143520531 0.0460507185697911 1.00487804878049 0.666666666666667 5.1 5 1 increased body temperature 0.00724778143520531 0.0460507185697911 1.00487804878049 0.666666666666667 5.1 5 1 abnormal tumor vascularization 0.0119163265715321 0.0671414961383204 1.00487804878049 0.666666666666667 5.1 5 1 increased muscle cell glucose uptake 0.0119163265715321 0.0671414961383204 1.00487804878049 0.666666666666667 5.1 5 1 abnormal megakaryocyte differentiation 0.0197513538220439 0.0980668515615455 1.00487804878049 0.666666666666667 5.1 5 1 cortical renal glomerulopathies 0.0197513538220439 0.0980668515615455 1.00487804878049 0.666666666666667 5.1 5 1 abnormal thymus medulla morphology 0.0197513538220439 0.0980668515615455 1.00487804878049 0.666666666666667 5.1 5 1 long tibia 0.0197513538220439 0.0980668515615455 1.00487804878049 0.666666666666667 5.1 5 1 abnormal anterior eye segment morphology 0.0197513538220439 0.0980668515615455 1.00487804878049 0.666666666666667 5.1 5 1 decreased tumor latency 0.0197513538220439 0.0980668515615455 1.00487804878049 0.666666666666667 5.1 5 1 decreased hepatocyte number 0.0330943130975815 0.14096250655862 1.00487804878049 0.666666666666667 5.1 5 1 no suckling reflex 0.0330943130975815 0.14096250655862 1.00487804878049 0.666666666666667 5.1 5 1 abnormal apical ectodermal ridge morphology 0.0330943130975815 0.14096250655862 1.00487804878049 0.666666666666667 5.1 5 1 delayed intramembranous bone ossification 0.0330943130975815 0.14096250655862 1.00487804878049 0.666666666666667 5.1 5 1 abnormal glial cell morphology 0.0330943130975815 0.14096250655862 1.00487804878049 0.666666666666667 5.1 5 1 abnormal placenta size 0.0330943130975815 0.14096250655862 1.00487804878049 0.666666666666667 5.1 5 1 abnormal rostral migratory stream morphology 0.0330943130975815 0.14096250655862 1.00487804878049 0.666666666666667 5.1 5 1 abnormal neurotransmitter secretion 0.0330943130975815 0.14096250655862 1.00487804878049 0.666666666666667 5.1 5 1 abnormal secondary palate development 0.0330943130975815 0.14096250655862 1.00487804878049 0.666666666666667 5.1 5 1 abnormal coronary vessel morphology 0.0330943130975815 0.14096250655862 1.00487804878049 0.666666666666667 5.1 5 1 heterochrony 0.0330943130975815 0.14096250655862 1.00487804878049 0.666666666666667 5.1 5 1 decreased brown adipose tissue mass 0.0330943130975815 0.14096250655862 1.00487804878049 0.666666666666667 5.1 5 1 abnormal adipose tissue distribution 0.0563025978025177 0.201168604876904 1.00487804878049 0.666666666666667 5.1 5 1 abnormal supraoccipital bone morphology 0.0563025978025177 0.201168604876904 1.00487804878049 0.666666666666667 5.1 5 1 abnormal mineral level 0.0563025978025177 0.201168604876904 1.00487804878049 0.666666666666667 5.1 5 1 decreased digestive secretion 0.0563025978025177 0.201168604876904 1.00487804878049 0.666666666666667 5.1 5 1 impaired embryo implantation 0.0563025978025177 0.201168604876904 1.00487804878049 0.666666666666667 5.1 5 1 myocarditis 0.0563025978025177 0.201168604876904 1.00487804878049 0.666666666666667 5.1 5 1 interstitial pneumonia 0.0563025978025177 0.201168604876904 1.00487804878049 0.666666666666667 5.1 5 1 increased papilloma incidence 0.0563025978025177 0.201168604876904 1.00487804878049 0.666666666666667 5.1 5 1 abnormal tracheal ciliated epithelium morphology 0.0563025978025177 0.201168604876904 1.00487804878049 0.666666666666667 5.1 5 1 abnormal gastrocnemius morphology 0.0563025978025177 0.201168604876904 1.00487804878049 0.666666666666667 5.1 5 1 small intestinal inflammation 0.0563025978025177 0.201168604876904 1.00487804878049 0.666666666666667 5.1 5 1 increased fear-related response 0.0563025978025177 0.201168604876904 1.00487804878049 0.666666666666667 5.1 5 1 absent ovary 0.0563025978025177 0.201168604876904 1.00487804878049 0.666666666666667 5.1 5 1 decreased left ventricle systolic pressure 0.0563025978025177 0.201168604876904 1.00487804878049 0.666666666666667 5.1 5 1 decreased cochlear nerve compound action potential 0.0563025978025177 0.201168604876904 1.00487804878049 0.666666666666667 5.1 5 1 hematuria 0.0563025978025177 0.201168604876904 1.00487804878049 0.666666666666667 5.1 5 1 abnormal patella morphology 0.0563025978025177 0.201168604876904 1.00487804878049 0.666666666666667 5.1 5 1 abnormal behavioral response to addictive substance 0.0563025978025177 0.201168604876904 1.00487804878049 0.666666666666667 5.1 5 1 decreased prostaglandin level 0.0563025978025177 0.201168604876904 1.00487804878049 0.666666666666667 5.1 5 1 decreased red blood cell distribution width 0.0563025978025177 0.201168604876904 1.00487804878049 0.666666666666667 5.1 5 1 abnormal cholinergic neuron morphology 0.0980275113629704 0.281411926734436 1.00487804878049 0.666666666666667 5.1 5 1 dilated uterus 0.0980275113629704 0.281411926734436 1.00487804878049 0.666666666666667 5.1 5 1 abnormal vagina epithelium morphology 0.0980275113629704 0.281411926734436 1.00487804878049 0.666666666666667 5.1 5 1 abnormal kindling response 0.0980275113629704 0.281411926734436 1.00487804878049 0.666666666666667 5.1 5 1 abnormal postural reflex 0.0980275113629704 0.281411926734436 1.00487804878049 0.666666666666667 5.1 5 1 pancreas cysts 0.0980275113629704 0.281411926734436 1.00487804878049 0.666666666666667 5.1 5 1 premature bone ossification 0.0980275113629704 0.281411926734436 1.00487804878049 0.666666666666667 5.1 5 1 impaired febrile response 0.0980275113629704 0.281411926734436 1.00487804878049 0.666666666666667 5.1 5 1 abnormal proprioceptive neuron morphology 0.0980275113629704 0.281411926734436 1.00487804878049 0.666666666666667 5.1 5 1 decreased vestibular hair cell number 0.0980275113629704 0.281411926734436 1.00487804878049 0.666666666666667 5.1 5 1 small scapula 0.0980275113629704 0.281411926734436 1.00487804878049 0.666666666666667 5.1 5 1 abnormal hair cell mechanoelectric transduction 0.0980275113629704 0.281411926734436 1.00487804878049 0.666666666666667 5.1 5 1 positive geotaxis 0.0980275113629704 0.281411926734436 1.00487804878049 0.666666666666667 5.1 5 1 enhanced conditioned place preference behavior 0.0980275113629704 0.281411926734436 1.00487804878049 0.666666666666667 5.1 5 1 eye opacity 0.0980275113629704 0.281411926734436 1.00487804878049 0.666666666666667 5.1 5 1 abnormal cerebellar layer morphology 0.0980275113629704 0.281411926734436 1.00487804878049 0.666666666666667 5.1 5 1 abnormal telomere morphology 0.0980275113629704 0.281411926734436 1.00487804878049 0.666666666666667 5.1 5 1 iris coloboma 0.0980275113629704 0.281411926734436 1.00487804878049 0.666666666666667 5.1 5 1 abnormal ureteric bud invasion 0.0980275113629704 0.281411926734436 1.00487804878049 0.666666666666667 5.1 5 1 increased core body temperature 0.0980275113629704 0.281411926734436 1.00487804878049 0.666666666666667 5.1 5 1 increased myeloid cell number 0.0980275113629704 0.281411926734436 1.00487804878049 0.666666666666667 5.1 5 1 abnormal ductus venosus valve topology 0.0980275113629704 0.281411926734436 1.00487804878049 0.666666666666667 5.1 5 1 decreased bone mineral density of femur 0.0980275113629704 0.281411926734436 1.00487804878049 0.666666666666667 5.1 5 1 increased endoplasmic reticulum stress 0.0980275113629704 0.281411926734436 1.00487804878049 0.666666666666667 5.1 5 1 increased circulating HDL cholesterol level 2.56132345662223e-08 8.97365084274336e-07 1.00487804878049 0.666666666666667 5.1 5 1 abnormal response to novel object 9.90596184774407e-05 0.00141209628058816 1.00487804878049 0.666666666666667 5.1 5 1 neonatal lethality, complete penetrance 9.00160142432362e-31 2.98553113906734e-28 1.00157252888318 0.664473684210526 5.1 5 1 anemia 6.31230368680652e-15 6.28074216837249e-13 1.000115593573 0.663507109004739 5.1 5 1 decreased cardiac muscle contractility 4.31830194032984e-08 1.42275179822125e-06 1.0000469043152 0.663461538461538 5.1 5 1 male infertility 3.22727132572204e-33 1.33797290378893e-30 0.997885855598119 0.662027833001988 5.1 5 1 postnatal lethality, incomplete penetrance 2.45326445232364e-37 1.22049906503101e-34 0.99780144280316 0.661971830985915 5.1 5 1 increased circulating free fatty acid level 6.56466259535379e-06 0.000132506326533894 0.99780144280316 0.661971830985915 5.1 5 1 prenatal lethality 2.6171167432626e-05 0.000450524422066832 0.996774193548387 0.661290322580645 5.1 5 1 embryonic lethality during organogenesis, incomplete penetrance 7.57832677572808e-16 9.4255439273118e-14 0.996139978791092 0.660869565217391 5.1 5 1 increased bone mineral content 2.92207725934792e-08 1.00953710869833e-06 0.995658984112777 0.660550458715596 5.1 5 1 abnormal interventricular septum morphology 0.000167836347490255 0.0021744422624063 0.994829268292683 0.66 5.1 5 1 abnormal hindlimb morphology 0.000167836347490255 0.0021744422624063 0.994829268292683 0.66 5.1 5 1 decreased respiratory quotient 0.000167836347490255 0.0021744422624063 0.994829268292683 0.66 5.1 5 1 abnormal myocardial fiber morphology 1.79947314680999e-07 5.26610523845866e-06 0.994518481267287 0.65979381443299 5.1 5 1 abnormal cell nucleus morphology 0.000267997833932314 0.00317483933838475 0.994187856772185 0.659574468085106 5.1 5 1 teratozoospermia 7.0607366288569e-07 1.80424713912545e-05 0.993458980044346 0.659090909090909 5.1 5 1 omphalocele 0.000428669571678631 0.00473766448843164 0.993458980044346 0.659090909090909 5.1 5 1 abnormal mammary gland development 0.000687011751977065 0.00686321981141747 0.992623438429506 0.658536585365854 5.1 5 1 abnormal placenta morphology 2.78180713122164e-06 6.18472576432396e-05 0.992158073479469 0.658227848101266 5.1 5 1 abnormal visceral yolk sac morphology 2.78180713122164e-06 6.18472576432396e-05 0.992158073479469 0.658227848101266 5.1 5 1 decreased percent body fat/body weight 6.95868022538731e-06 0.0001390338719731 0.991112596057467 0.657534246575342 5.1 5 1 increased circulating serum albumin level 0.00177718518668883 0.0150621742824138 0.990522648083624 0.657142857142857 5.1 5 1 decreased triglyceride level 0.00177718518668883 0.0150621742824138 0.990522648083624 0.657142857142857 5.1 5 1 decreased circulating thyroxine level 0.00177718518668883 0.0150621742824138 0.990522648083624 0.657142857142857 5.1 5 1 abnormal retina morphology 3.13290773094213e-14 2.78325285025663e-12 0.990522648083624 0.657142857142857 5.1 5 1 decreased circulating serum albumin level 1.90669556341172e-07 5.51500606277518e-06 0.989652623798965 0.656565656565657 5.1 5 1 cleft palate 2.17288787801793e-09 9.73884431814342e-08 0.989536399180786 0.656488549618321 5.1 5 1 decreased circulating LDL cholesterol level 2.76767325068982e-05 0.000474799118006272 0.989176829268293 0.65625 5.1 5 1 abnormal diaphragm morphology 0.0028708505153248 0.0221777660151256 0.989176829268293 0.65625 5.1 5 1 abnormal embryonic hematopoiesis 0.0028708505153248 0.0221777660151256 0.989176829268293 0.65625 5.1 5 1 increased fibroblast apoptosis 0.0028708505153248 0.0221777660151256 0.989176829268293 0.65625 5.1 5 1 abnormal retinal pigmentation 1.17833837640536e-06 2.88779971557471e-05 0.987552565180824 0.655172413793103 5.1 5 1 thrombocytosis 6.97799665154672e-05 0.00106163710524296 0.987552565180824 0.655172413793103 5.1 5 1 lordosis 0.00465441176759854 0.0322952559885673 0.987552565180824 0.655172413793103 5.1 5 1 premature death 2.64232884735004e-53 2.62911720311329e-50 0.9873714625648 0.655052264808362 5.1 5 1 increased exploration in new environment 2.93673912078136e-06 6.49345650039433e-05 0.986269196025294 0.654320987654321 5.1 5 1 decreased body weight 3.11677830544046e-76 1.55059720695663e-72 0.986209070491351 0.654281098546042 5.1 5 1 abnormal cornea morphology 4.6397148282005e-06 9.86435097021261e-05 0.985553470919324 0.653846153846154 5.1 5 1 decreased kidney weight 0.000176706277543469 0.00225993246986827 0.985553470919324 0.653846153846154 5.1 5 1 ventricular hypoplasia 0.00757914014287981 0.0475948853774615 0.985553470919324 0.653846153846154 5.1 5 1 abnormal Schwann cell morphology 0.00757914014287981 0.0475948853774615 0.985553470919324 0.653846153846154 5.1 5 1 blistering 0.0124082547575156 0.0689732596856314 0.983032873806999 0.652173913043478 5.1 5 1 increased susceptibility to age related obesity 0.0124082547575156 0.0689732596856314 0.983032873806999 0.652173913043478 5.1 5 1 decreased effector memory CD8-positive, alpha-beta T cell number 0.0124082547575156 0.0689732596856314 0.983032873806999 0.652173913043478 5.1 5 1 increased circulating creatinine level 1.95536591121298e-06 4.58865349447386e-05 0.981508791832104 0.651162790697674 5.1 5 1 abnormal organ of Corti morphology 0.000719735287711268 0.00703053678964919 0.981508791832104 0.651162790697674 5.1 5 1 abnormal left-right axis patterning 0.000719735287711268 0.00703053678964919 0.981508791832104 0.651162790697674 5.1 5 1 decreased oxygen consumption 0.000719735287711268 0.00703053678964919 0.981508791832104 0.651162790697674 5.1 5 1 enlarged heart 6.80950063449905e-15 6.64260110914368e-13 0.98105550883095 0.650862068965517 5.1 5 1 embryonic growth arrest 1.06645034098758e-14 9.82516749335775e-13 0.980743423154755 0.650655021834061 5.1 5 1 postnatal lethality 4.64946465836207e-11 2.75370079468468e-09 0.980664119894211 0.650602409638554 5.1 5 1 head bobbing 0.00115360027663036 0.0105305713325432 0.979756097560976 0.65 5.1 5 1 abnormal pancreatic beta cell morphology 0.00115360027663036 0.0105305713325432 0.979756097560976 0.65 5.1 5 1 abnormal cell proliferation 0.0204521308597049 0.100642285882326 0.979756097560976 0.65 5.1 5 1 anencephaly 0.0204521308597049 0.100642285882326 0.979756097560976 0.65 5.1 5 1 decreased myocardial infarction size 0.0204521308597049 0.100642285882326 0.979756097560976 0.65 5.1 5 1 dilated vasculature 0.0204521308597049 0.100642285882326 0.979756097560976 0.65 5.1 5 1 increased skin tumor incidence 0.0204521308597049 0.100642285882326 0.979756097560976 0.65 5.1 5 1 abnormal kidney development 7.31457204469971e-05 0.00109608421452955 0.979756097560976 0.65 5.1 5 1 abnormal incisor morphology 7.31457204469971e-05 0.00109608421452955 0.979756097560976 0.65 5.1 5 1 increased total body fat amount 3.98578704340316e-09 1.66632693621267e-07 0.978631234073535 0.649253731343284 5.1 5 1 incomplete embryo turning 0.000116161525559853 0.00162332469005693 0.978433889602054 0.649122807017544 5.1 5 1 respiratory failure 4.40174240634978e-10 2.21198671430204e-08 0.978258762720078 0.649006622516556 5.1 5 1 abnormal hepatocyte morphology 8.9586914616047e-08 2.80311257996751e-06 0.977719182597231 0.648648648648649 5.1 5 1 pale liver 1.21502270923893e-05 0.000232373737379248 0.977719182597231 0.648648648648649 5.1 5 1 increased trabecular bone volume 0.00185318493888021 0.0155736403225153 0.977719182597231 0.648648648648649 5.1 5 1 abnormal mandible morphology 0.000184669685973523 0.0023557222762007 0.976964769647696 0.648148148148148 5.1 5 1 hyperglycemia 2.04669607545767e-06 4.75809017542146e-05 0.976330376940133 0.647727272727273 5.1 5 1 increased heart weight 2.66052339545452e-09 1.18179499039163e-07 0.975960694858747 0.647482014388489 5.1 5 1 respiratory distress 3.26187400019427e-11 2.00343495690944e-09 0.975835330607641 0.647398843930636 5.1 5 1 distended abdomen 0.000293927017347084 0.00344878988514562 0.97532281205165 0.647058823529412 5.1 5 1 lung hemorrhage 0.00298482310746457 0.022775299017847 0.97532281205165 0.647058823529412 5.1 5 1 abnormal brown adipose tissue morphology 0.00298482310746457 0.022775299017847 0.97532281205165 0.647058823529412 5.1 5 1 abnormal nervous system development 0.00298482310746457 0.022775299017847 0.97532281205165 0.647058823529412 5.1 5 1 hydroureter 0.0340071638128369 0.142600969940433 0.97532281205165 0.647058823529412 5.1 5 1 abnormal cranial suture morphology 0.0340071638128369 0.142600969940433 0.97532281205165 0.647058823529412 5.1 5 1 abnormal ectoplacental cone morphology 0.0340071638128369 0.142600969940433 0.97532281205165 0.647058823529412 5.1 5 1 decreased growth hormone level 0.0340071638128369 0.142600969940433 0.97532281205165 0.647058823529412 5.1 5 1 abnormal survival 0.0340071638128369 0.142600969940433 0.97532281205165 0.647058823529412 5.1 5 1 abnormal electroretinogram waveform feature 0.0340071638128369 0.142600969940433 0.97532281205165 0.647058823529412 5.1 5 1 curly tail 0.000468438783780578 0.00509952505319119 0.973475609756098 0.645833333333333 5.1 5 1 hunched posture 8.02376099055494e-06 0.000158405598920678 0.973078110527941 0.645569620253165 5.1 5 1 hypoglycemia 1.35539016168476e-06 3.25751983303464e-05 0.972462627852085 0.645161290322581 5.1 5 1 lethargy 1.35539016168476e-06 3.25751983303464e-05 0.972462627852085 0.645161290322581 5.1 5 1 increased tumor incidence 2.52517823020003e-08 8.90976006754975e-07 0.972462627852085 0.645161290322581 5.1 5 1 abnormal autopod morphology 0.000747660586116347 0.00720854925567602 0.971382113821138 0.644444444444444 5.1 5 1 abnormal myocardial trabeculae morphology 0.000747660586116347 0.00720854925567602 0.971382113821138 0.644444444444444 5.1 5 1 small placenta 0.000747660586116347 0.00720854925567602 0.971382113821138 0.644444444444444 5.1 5 1 abnormal metabolism 0.000747660586116347 0.00720854925567602 0.971382113821138 0.644444444444444 5.1 5 1 decreased hematocrit 1.84886519620021e-09 8.59635920663181e-08 0.970464416972937 0.643835616438356 5.1 5 1 abnormal fertility/fecundity 1.99928011921519e-05 0.000354913712285058 0.970464416972937 0.643835616438356 5.1 5 1 hydronephrosis 5.29038515392447e-06 0.000111053443631959 0.968989547038328 0.642857142857143 5.1 5 1 abnormal optic nerve morphology 0.00119529667148171 0.0108721286777338 0.968989547038328 0.642857142857143 5.1 5 1 abnormal jaw morphology 0.0078191187517347 0.0486251447373502 0.968989547038327 0.642857142857143 5.1 5 1 enhanced coordination 0.0078191187517347 0.0486251447373502 0.968989547038327 0.642857142857143 5.1 5 1 abnormal mitotic spindle morphology 0.0078191187517347 0.0486251447373502 0.968989547038327 0.642857142857143 5.1 5 1 prolonged QRS complex duration 0.0078191187517347 0.0486251447373502 0.968989547038327 0.642857142857143 5.1 5 1 abnormal zigzag hair morphology 0.057216799176044 0.201168604876904 0.968989547038327 0.642857142857143 5.1 5 1 translucent skin 0.057216799176044 0.201168604876904 0.968989547038327 0.642857142857143 5.1 5 1 abnormal pinna reflex 0.057216799176044 0.201168604876904 0.968989547038327 0.642857142857143 5.1 5 1 abnormal prepulse inhibition 0.057216799176044 0.201168604876904 0.968989547038327 0.642857142857143 5.1 5 1 intestinal obstruction 0.057216799176044 0.201168604876904 0.968989547038327 0.642857142857143 5.1 5 1 absent olfactory bulb 0.057216799176044 0.201168604876904 0.968989547038327 0.642857142857143 5.1 5 1 abnormal uterus development 0.057216799176044 0.201168604876904 0.968989547038327 0.642857142857143 5.1 5 1 skeletal muscle necrosis 0.057216799176044 0.201168604876904 0.968989547038327 0.642857142857143 5.1 5 1 lysosomal protein accumulation 0.057216799176044 0.201168604876904 0.968989547038327 0.642857142857143 5.1 5 1 abnormal iris pigmentation 0.057216799176044 0.201168604876904 0.968989547038327 0.642857142857143 5.1 5 1 sternebra fusion 0.057216799176044 0.201168604876904 0.968989547038327 0.642857142857143 5.1 5 1 absent gastric milk in neonates 1.3136482366112e-05 0.000249442747219112 0.966228893058161 0.641025641025641 5.1 5 1 abnormal heart looping 0.00191453516149364 0.0159011893629898 0.966228893058161 0.641025641025641 5.1 5 1 failure of heart looping 0.00191453516149364 0.0159011893629898 0.966228893058161 0.641025641025641 5.1 5 1 abnormal osteoclast physiology 7.89505112851835e-05 0.00117598441210715 0.965625 0.640625 5.1 5 1 decreased birth body size 1.58818132223144e-07 4.70309647506038e-06 0.965211810012837 0.640350877192982 5.1 5 1 increased circulating chloride level 0.000484268067058352 0.00524887501876972 0.964682926829268 0.64 5.1 5 1 abnormal thyroid gland morphology 0.0127340191501333 0.0698628978993204 0.964682926829268 0.64 5.1 5 1 spontaneous skin ulceration 0.0127340191501333 0.0698628978993204 0.964682926829268 0.64 5.1 5 1 abnormal egg cylinder morphology 0.0127340191501333 0.0698628978993204 0.964682926829268 0.64 5.1 5 1 abnormal vertebrae development 0.0127340191501333 0.0698628978993204 0.964682926829268 0.64 5.1 5 1 increased liver glycogen level 0.0127340191501333 0.0698628978993204 0.964682926829268 0.64 5.1 5 1 abnormal embryonic tissue morphology 3.12098289429906e-09 1.35016433905546e-07 0.963862618218019 0.639455782312925 5.1 5 1 decreased bone mineral content 1.88967176451778e-12 1.40315179529492e-10 0.963813320825516 0.639423076923077 5.1 5 1 abnormal cardiovascular system physiology 1.80598151152952e-08 6.6779547709975e-07 0.963322941500092 0.639097744360902 5.1 5 1 neonatal lethality, incomplete penetrance 4.41976215170817e-15 4.5808993134892e-13 0.962363977485929 0.638461538461538 5.1 5 1 decreased hemoglobin content 7.63422209349643e-09 3.0878256028573e-07 0.962117280747276 0.638297872340426 5.1 5 1 decreased spleen weight 5.15515246604906e-05 0.000822015497390835 0.96118769883351 0.63768115942029 5.1 5 1 abnormal food intake 5.15515246604906e-05 0.000822015497390835 0.96118769883351 0.63768115942029 5.1 5 1 increased circulating insulin level 8.74828703533169e-10 4.22550757289079e-08 0.960914634146342 0.6375 5.1 5 1 abnormal extraembryonic tissue morphology 9.60501602062774e-07 2.38290912099829e-05 0.960545193687231 0.637254901960784 5.1 5 1 lethality, incomplete penetrance 0.00122910029076838 0.0111551283366947 0.95920177383592 0.636363636363636 5.1 5 1 increased body size 0.0208497093025141 0.100888023213767 0.95920177383592 0.636363636363636 5.1 5 1 abnormal germ layer development 0.0208497093025141 0.100888023213767 0.95920177383592 0.636363636363636 5.1 5 1 intracerebral hemorrhage 0.0208497093025141 0.100888023213767 0.95920177383592 0.636363636363636 5.1 5 1 increased skin papilloma incidence 0.0208497093025141 0.100888023213767 0.95920177383592 0.636363636363636 5.1 5 1 abnormal tracheal cartilage morphology 0.0208497093025141 0.100888023213767 0.95920177383592 0.636363636363636 5.1 5 1 prolonged PR interval 0.0208497093025141 0.100888023213767 0.95920177383592 0.636363636363636 5.1 5 1 decreased circulating estradiol level 0.0208497093025141 0.100888023213767 0.95920177383592 0.636363636363636 5.1 5 1 increased adenoma incidence 0.0208497093025141 0.100888023213767 0.95920177383592 0.636363636363636 5.1 5 1 embryonic lethality before implantation, incomplete penetrance 0.0208497093025141 0.100888023213767 0.95920177383592 0.636363636363636 5.1 5 1 abnormal ear position 0.0978921089751002 0.281411926734436 0.95920177383592 0.636363636363636 5.1 5 1 abnormal sebaceous gland morphology 0.0978921089751002 0.281411926734436 0.95920177383592 0.636363636363636 5.1 5 1 abnormal glossopharyngeal ganglion morphology 0.0978921089751002 0.281411926734436 0.95920177383592 0.636363636363636 5.1 5 1 abnormal hypothalamus secretion 0.0978921089751002 0.281411926734436 0.95920177383592 0.636363636363636 5.1 5 1 abnormal vestibular ganglion morphology 0.0978921089751002 0.281411926734436 0.95920177383592 0.636363636363636 5.1 5 1 patent ductus arteriosus 0.0978921089751002 0.281411926734436 0.95920177383592 0.636363636363636 5.1 5 1 abnormal frequency of paradoxical sleep 0.0978921089751002 0.281411926734436 0.95920177383592 0.636363636363636 5.1 5 1 loss of cortex neurons 0.0978921089751002 0.281411926734436 0.95920177383592 0.636363636363636 5.1 5 1 impaired luteinization 0.0978921089751002 0.281411926734436 0.95920177383592 0.636363636363636 5.1 5 1 pulmonary hypertension 0.0978921089751002 0.281411926734436 0.95920177383592 0.636363636363636 5.1 5 1 abnormal coronal suture morphology 0.0978921089751002 0.281411926734436 0.95920177383592 0.636363636363636 5.1 5 1 pharyngeal arch hypoplasia 0.0978921089751002 0.281411926734436 0.95920177383592 0.636363636363636 5.1 5 1 abnormal crista ampullaris neuroepithelium morphology 0.0978921089751002 0.281411926734436 0.95920177383592 0.636363636363636 5.1 5 1 increased motor neuron number 0.0978921089751002 0.281411926734436 0.95920177383592 0.636363636363636 5.1 5 1 increased number of Howell-Jolly bodies 0.0978921089751002 0.281411926734436 0.95920177383592 0.636363636363636 5.1 5 1 common atrioventricular valve 0.0978921089751002 0.281411926734436 0.95920177383592 0.636363636363636 5.1 5 1 abnormal phrenic nerve innervation pattern to diaphragm 0.0978921089751002 0.281411926734436 0.95920177383592 0.636363636363636 5.1 5 1 increased insulin sensitivity 7.88688482404066e-09 3.14349078770978e-07 0.95920177383592 0.636363636363636 5.1 5 1 abnormal platelet physiology 0.000313634369305496 0.00360353576742458 0.95920177383592 0.636363636363636 5.1 5 1 abnormal skeleton physiology 0.0049451516922685 0.0336927055754571 0.95920177383592 0.636363636363636 5.1 5 1 decreased brown adipose tissue amount 0.0049451516922685 0.0336927055754571 0.95920177383592 0.636363636363636 5.1 5 1 cardiovascular system phenotype 0.0049451516922685 0.0336927055754571 0.95920177383592 0.636363636363636 5.1 5 1 cyanosis 2.82213159948304e-11 1.80001342402924e-09 0.957774390243903 0.635416666666667 5.1 5 1 azoospermia 1.41007782954923e-09 6.61805396415796e-08 0.957478140819144 0.635220125786163 5.1 5 1 abnormal hair follicle morphology 0.000128552559153038 0.00177160382766307 0.957026713124274 0.634920634920635 5.1 5 1 abnormal snout morphology 0.000497520933848099 0.00538079705629194 0.95656660412758 0.634615384615385 5.1 5 1 postnatal growth retardation 2.18800540907695e-32 8.37332839242909e-30 0.955619320899091 0.633986928104575 5.1 5 1 increased erythrocyte cell number 0.000203162542832675 0.00256169067505689 0.954634146341463 0.633333333333333 5.1 5 1 muscular ventricular septal defect 0.000203162542832675 0.00256169067505689 0.954634146341463 0.633333333333333 5.1 5 1 disorganized myocardium 0.00798041614561029 0.049197732744004 0.954634146341463 0.633333333333333 5.1 5 1 abnormal cellular respiration 0.00798041614561029 0.049197732744004 0.954634146341463 0.633333333333333 5.1 5 1 abnormal eye morphology 1.98185035434891e-08 7.24978346535722e-07 0.954272679417442 0.633093525179856 5.1 5 1 abnormal somite development 2.19515192205207e-05 0.000385896848487953 0.953998147576413 0.632911392405063 5.1 5 1 absent kidney 0.000789955313481683 0.00757230767740148 0.953608760577402 0.63265306122449 5.1 5 1 increased T cell derived lymphoma incidence 0.000789955313481683 0.00757230767740148 0.953608760577402 0.63265306122449 5.1 5 1 embryonic lethality before implantation, complete penetrance 1.14700821510453e-07 3.50083795714419e-06 0.952624390243902 0.632 5.1 5 1 decreased birth weight 3.80558279832628e-06 8.23164105290141e-05 0.95198973042362 0.631578947368421 5.1 5 1 hyporesponsive to tactile stimuli 0.0031383159775029 0.0238004908354831 0.95198973042362 0.631578947368421 5.1 5 1 shiny skin 0.034367550343433 0.142600969940433 0.95198973042362 0.631578947368421 5.1 5 1 delayed sexual maturation 0.034367550343433 0.142600969940433 0.95198973042362 0.631578947368421 5.1 5 1 decreased tumor incidence 0.034367550343433 0.142600969940433 0.95198973042362 0.631578947368421 5.1 5 1 increased susceptibility to ischemic brain injury 0.034367550343433 0.142600969940433 0.95198973042362 0.631578947368421 5.1 5 1 abnormal response to novelty 0.034367550343433 0.142600969940433 0.95198973042362 0.631578947368421 5.1 5 1 abnormal digestive system development 0.034367550343433 0.142600969940433 0.95198973042362 0.631578947368421 5.1 5 1 increased liver adenoma incidence 0.034367550343433 0.142600969940433 0.95198973042362 0.631578947368421 5.1 5 1 abnormal optic vesicle formation 0.034367550343433 0.142600969940433 0.95198973042362 0.631578947368421 5.1 5 1 oliguria 0.034367550343433 0.142600969940433 0.95198973042362 0.631578947368421 5.1 5 1 abnormal blastocyst morphology 0.034367550343433 0.142600969940433 0.95198973042362 0.631578947368421 5.1 5 1 decreased fertilization frequency 0.034367550343433 0.142600969940433 0.95198973042362 0.631578947368421 5.1 5 1 decreased liver glycogen level 0.034367550343433 0.142600969940433 0.95198973042362 0.631578947368421 5.1 5 1 small testis 5.61450768533453e-15 5.70044402745699e-13 0.950265111346766 0.630434782608696 5.1 5 1 enlarged liver 2.48935678052684e-06 5.62934090141865e-05 0.949609756097561 0.63 5.1 5 1 increased or absent threshold for auditory brainstem response 1.56952176159883e-15 1.81590017766376e-13 0.949244661996793 0.629757785467128 5.1 5 1 abnormal chondrocyte morphology 0.000508323644513382 0.00543077607652045 0.949051490514905 0.62962962962963 5.1 5 1 diluted coat color 0.000508323644513382 0.00543077607652045 0.949051490514905 0.62962962962963 5.1 5 1 abnormal trigeminal nerve morphology 0.0129223430088443 0.0704397686787555 0.949051490514905 0.62962962962963 5.1 5 1 abnormal rib morphology 4.94985590305752e-08 1.60951196847785e-06 0.949051490514905 0.62962962962963 5.1 5 1 postnatal lethality, complete penetrance 3.28734320628511e-20 6.2902047889494e-18 0.948906862125616 0.629533678756477 5.1 5 1 perinatal lethality, complete penetrance 8.80005276106955e-12 5.99729623100287e-10 0.948265200961869 0.629107981220657 5.1 5 1 abnormal dermal layer morphology 0.00502851805031579 0.0340785178541808 0.947456445993031 0.628571428571429 5.1 5 1 decreased circulating cholesterol level 2.80453383638789e-10 1.46869008800313e-08 0.947221111555378 0.628415300546448 5.1 5 1 thrombocytopenia 2.13339480317592e-08 7.6910428592755e-07 0.945971404541632 0.627586206896552 5.1 5 1 small lung 0.000804842466572072 0.00761234081976437 0.945767575322812 0.627450980392157 5.1 5 1 kyphosis 1.400060122844e-08 5.48448748909361e-07 0.944585365853658 0.626666666666667 5.1 5 1 abnormal testis morphology 6.96178738114653e-07 1.80390063652104e-05 0.943711558854719 0.626086956521739 5.1 5 1 abnormal skin pigmentation 0.00318275996959912 0.0241008079889736 0.942073170731707 0.625 5.1 5 1 reduced female fertility 2.61715016052238e-12 1.86004600694269e-10 0.942073170731707 0.625 5.1 5 1 thymus atrophy 0.00127523092897723 0.0114532729939482 0.942073170731707 0.625 5.1 5 1 abnormal body weight 0.0210090436280327 0.100888023213767 0.942073170731707 0.625 5.1 5 1 hemolytic anemia 0.0210090436280327 0.100888023213767 0.942073170731707 0.625 5.1 5 1 abnormal vasodilation 0.0210090436280327 0.100888023213767 0.942073170731707 0.625 5.1 5 1 apnea 0.0210090436280327 0.100888023213767 0.942073170731707 0.625 5.1 5 1 decreased fatty acid level 0.0210090436280327 0.100888023213767 0.942073170731707 0.625 5.1 5 1 increased sacral vertebrae number 0.000211222638932797 0.00261401151415588 0.942073170731707 0.625 5.1 5 1 abnormal eye development 0.000516817720285693 0.0054358734850345 0.942073170731707 0.625 5.1 5 1 increased circulating follicle stimulating hormone level 0.00807456742790636 0.0496550963582622 0.942073170731707 0.625 5.1 5 1 abnormal tympanic ring morphology 0.0571410362586075 0.201168604876904 0.942073170731707 0.625 5.1 5 1 decreased mast cell number 0.0571410362586075 0.201168604876904 0.942073170731707 0.625 5.1 5 1 intraventricular hemorrhage 0.0571410362586075 0.201168604876904 0.942073170731707 0.625 5.1 5 1 abnormal epicardium morphology 0.0571410362586075 0.201168604876904 0.942073170731707 0.625 5.1 5 1 paternal imprinting 0.0571410362586075 0.201168604876904 0.942073170731707 0.625 5.1 5 1 decreased cochlear coiling 0.0571410362586075 0.201168604876904 0.942073170731707 0.625 5.1 5 1 abnormal pulmonary elastic fiber morphology 0.0571410362586075 0.201168604876904 0.942073170731707 0.625 5.1 5 1 increased pancreatic beta cell number 0.0571410362586075 0.201168604876904 0.942073170731707 0.625 5.1 5 1 decreased aggression towards mice 0.0571410362586075 0.201168604876904 0.942073170731707 0.625 5.1 5 1 bowed tibia 0.0571410362586075 0.201168604876904 0.942073170731707 0.625 5.1 5 1 bowed radius 0.0571410362586075 0.201168604876904 0.942073170731707 0.625 5.1 5 1 increased thymus weight 0.0571410362586075 0.201168604876904 0.942073170731707 0.625 5.1 5 1 blepharitis 0.0571410362586075 0.201168604876904 0.942073170731707 0.625 5.1 5 1 loose skin 0.0571410362586075 0.201168604876904 0.942073170731707 0.625 5.1 5 1 decreased skeletal muscle weight 0.0571410362586075 0.201168604876904 0.942073170731707 0.625 5.1 5 1 increased heart left ventricle size 0.0571410362586075 0.201168604876904 0.942073170731707 0.625 5.1 5 1 abnormal exoccipital bone morphology 0.171840924646193 0.385697839433079 0.942073170731707 0.625 5.1 5 1 abnormal cecum morphology 0.171840924646193 0.385697839433079 0.942073170731707 0.625 5.1 5 1 clubfoot 0.171840924646193 0.385697839433079 0.942073170731707 0.625 5.1 5 1 abnormal pupil morphology 0.171840924646193 0.385697839433079 0.942073170731707 0.625 5.1 5 1 unidirectional circling 0.171840924646193 0.385697839433079 0.942073170731707 0.625 5.1 5 1 abnormal erythrocyte cell number 0.171840924646193 0.385697839433079 0.942073170731707 0.625 5.1 5 1 abnormal urination 0.171840924646193 0.385697839433079 0.942073170731707 0.625 5.1 5 1 abnormal pulmonary circulation 0.171840924646193 0.385697839433079 0.942073170731707 0.625 5.1 5 1 coarse hair 0.171840924646193 0.385697839433079 0.942073170731707 0.625 5.1 5 1 decreased corneal stroma thickness 0.171840924646193 0.385697839433079 0.942073170731707 0.625 5.1 5 1 abnormal cellular cholesterol metabolism 0.171840924646193 0.385697839433079 0.942073170731707 0.625 5.1 5 1 abnormal umbilical artery morphology 0.171840924646193 0.385697839433079 0.942073170731707 0.625 5.1 5 1 loss of GABAergic neurons 0.171840924646193 0.385697839433079 0.942073170731707 0.625 5.1 5 1 liver failure 0.171840924646193 0.385697839433079 0.942073170731707 0.625 5.1 5 1 abnormal platelet shape 0.171840924646193 0.385697839433079 0.942073170731707 0.625 5.1 5 1 hair follicle degeneration 0.171840924646193 0.385697839433079 0.942073170731707 0.625 5.1 5 1 pulmonary interstitial fibrosis 0.171840924646193 0.385697839433079 0.942073170731707 0.625 5.1 5 1 binucleate 0.171840924646193 0.385697839433079 0.942073170731707 0.625 5.1 5 1 lymph node inflammation 0.171840924646193 0.385697839433079 0.942073170731707 0.625 5.1 5 1 abnormal extraembryonic tissue physiology 0.171840924646193 0.385697839433079 0.942073170731707 0.625 5.1 5 1 abnormal hair follicle melanocyte morphology 0.171840924646193 0.385697839433079 0.942073170731707 0.625 5.1 5 1 absent cochlear microphonics 0.171840924646193 0.385697839433079 0.942073170731707 0.625 5.1 5 1 increased epididymis weight 0.171840924646193 0.385697839433079 0.942073170731707 0.625 5.1 5 1 abnormal vertebral body development 0.171840924646193 0.385697839433079 0.942073170731707 0.625 5.1 5 1 Sertoli cell hypoplasia 0.171840924646193 0.385697839433079 0.942073170731707 0.625 5.1 5 1 abnormal ilium morphology 0.171840924646193 0.385697839433079 0.942073170731707 0.625 5.1 5 1 craniofacial phenotype 0.171840924646193 0.385697839433079 0.942073170731707 0.625 5.1 5 1 hypergranulosis 0.171840924646193 0.385697839433079 0.942073170731707 0.625 5.1 5 1 impaired behavioral response to alcohol 0.171840924646193 0.385697839433079 0.942073170731707 0.625 5.1 5 1 abnormal sphingomyelin level 0.171840924646193 0.385697839433079 0.942073170731707 0.625 5.1 5 1 skin fibrosis 0.171840924646193 0.385697839433079 0.942073170731707 0.625 5.1 5 1 abnormal circulating serum amyloid protein level 0.171840924646193 0.385697839433079 0.942073170731707 0.625 5.1 5 1 abnormal hepatic vein morphology 0.171840924646193 0.385697839433079 0.942073170731707 0.625 5.1 5 1 anomalous pulmonary venous connection 0.171840924646193 0.385697839433079 0.942073170731707 0.625 5.1 5 1 myocardial trabeculae hypoplasia 0.171840924646193 0.385697839433079 0.942073170731707 0.625 5.1 5 1 delayed suture closure 0.171840924646193 0.385697839433079 0.942073170731707 0.625 5.1 5 1 abnormal stomach position or orientation 0.171840924646193 0.385697839433079 0.942073170731707 0.625 5.1 5 1 increased aorta wall thickness 0.171840924646193 0.385697839433079 0.942073170731707 0.625 5.1 5 1 abnormal macrophage activation involved in immune response 0.171840924646193 0.385697839433079 0.942073170731707 0.625 5.1 5 1 decreased cranium length 0.171840924646193 0.385697839433079 0.942073170731707 0.625 5.1 5 1 decreased white adipose tissue mass 0.171840924646193 0.385697839433079 0.942073170731707 0.625 5.1 5 1 decreased bone mineral density 8.60115907903107e-14 7.5071520031894e-12 0.940656519347148 0.62406015037594 5.1 5 1 abnormal seminiferous tubule morphology 3.44887231961994e-08 1.17580537910727e-06 0.939492148346141 0.623287671232877 5.1 5 1 perimembraneous ventricular septal defect 0.000136379084812424 0.00184640166053885 0.939342523860021 0.623188405797101 5.1 5 1 enlarged kidney 0.000815936962622348 0.00764460713568019 0.938518177634607 0.622641509433962 5.1 5 1 abnormal pancreatic islet morphology 0.000815936962622348 0.00764460713568019 0.938518177634607 0.622641509433962 5.1 5 1 increased circulating bilirubin level 0.000815936962622348 0.00764460713568019 0.938518177634607 0.622641509433962 5.1 5 1 oxidative stress 1.51465262197724e-05 0.000283285593772059 0.937886178861789 0.622222222222222 5.1 5 1 abnormal ovarian follicle morphology 0.00202205980431291 0.0166828317188337 0.937886178861789 0.622222222222222 5.1 5 1 impaired skeletal muscle contractility 0.00507738242950041 0.0340785178541808 0.936980883322347 0.621621621621622 5.1 5 1 abnormal pancreatic beta cell physiology 0.00507738242950041 0.0340785178541808 0.936980883322347 0.621621621621622 5.1 5 1 abnormal calcium ion homeostasis 0.00507738242950041 0.0340785178541808 0.936980883322347 0.621621621621622 5.1 5 1 abnormal humerus morphology 0.00507738242950041 0.0340785178541808 0.936980883322347 0.621621621621622 5.1 5 1 insulin resistance 1.97665815365463e-07 5.65165190484584e-06 0.936363636363636 0.621212121212121 5.1 5 1 abnormal vascular development 0.000214078088967284 0.00264277541591126 0.936363636363636 0.621212121212121 5.1 5 1 abnormal parietal bone morphology 0.0129977301803211 0.0704397686787555 0.935576114381834 0.620689655172414 5.1 5 1 abnormal microglial cell morphology 0.0129977301803211 0.0704397686787555 0.935576114381834 0.620689655172414 5.1 5 1 decreased trophoblast giant cell number 0.0129977301803211 0.0704397686787555 0.935576114381834 0.620689655172414 5.1 5 1 short sternum 0.0129977301803211 0.0704397686787555 0.935576114381834 0.620689655172414 5.1 5 1 decreased leukocyte cell number 1.291457455531e-07 3.9176834397968e-06 0.935196724230016 0.62043795620438 5.1 5 1 decreased circulating alkaline phosphatase level 0.00128870818922501 0.011489826597481 0.934536585365854 0.62 5.1 5 1 abnormal ovary morphology 0.00013805585307525 0.00185336100130803 0.934111989007214 0.619718309859155 5.1 5 1 abnormal cranium morphology 2.00412053417133e-07 5.69742837571563e-06 0.933636694575901 0.619402985074627 5.1 5 1 abnormal cartilage morphology 0.00320882142216935 0.0242254113852485 0.933101045296167 0.619047619047619 5.1 5 1 small ears 0.0343228128279856 0.142600969940433 0.933101045296167 0.619047619047619 5.1 5 1 increased incidence of induced tumors 0.0343228128279856 0.142600969940433 0.933101045296167 0.619047619047619 5.1 5 1 abnormal erythrocyte physiology 0.0343228128279856 0.142600969940433 0.933101045296167 0.619047619047619 5.1 5 1 abnormal head morphology 0.000823534851992822 0.00768684031644332 0.93179600886918 0.618181818181818 5.1 5 1 abnormal rostral-caudal axis patterning 0.000823534851992822 0.00768684031644332 0.93179600886918 0.618181818181818 5.1 5 1 abnormal vision 0.00811183632925953 0.049822698442057 0.930989956958393 0.617647058823529 5.1 5 1 decreased heart weight 5.76075594899816e-05 0.000901250341077542 0.930442637759711 0.617283950617284 5.1 5 1 decreased lymphocyte cell number 4.82079079945866e-07 1.31057017635557e-05 0.930297256097561 0.6171875 5.1 5 1 decreased bone trabecula number 0.00203624848094222 0.0167318641441325 0.930046704722366 0.617021276595745 5.1 5 1 decreased bone marrow cell number 0.00013930491414874 0.00185723485261443 0.929168058803876 0.616438356164384 5.1 5 1 increased embryonic tissue cell apoptosis 8.98706288188675e-05 0.00131555641294101 0.927579737335835 0.615384615384615 5.1 5 1 distended pericardium 0.00129655691893043 0.011497986937039 0.927579737335835 0.615384615384615 5.1 5 1 absent corpus luteum 0.00129655691893043 0.011497986937039 0.927579737335835 0.615384615384615 5.1 5 1 eyelids open at birth 0.00129655691893043 0.011497986937039 0.927579737335835 0.615384615384615 5.1 5 1 impaired macrophage chemotaxis 0.00509636528311769 0.0340785178541808 0.927579737335835 0.615384615384615 5.1 5 1 increased hepatocyte apoptosis 0.00509636528311769 0.0340785178541808 0.927579737335835 0.615384615384615 5.1 5 1 abnormal response to injury 0.00509636528311769 0.0340785178541808 0.927579737335835 0.615384615384615 5.1 5 1 abnormal xiphoid process morphology 0.0209818255617391 0.100888023213767 0.927579737335835 0.615384615384615 5.1 5 1 small seminal vesicle 0.0209818255617391 0.100888023213767 0.927579737335835 0.615384615384615 5.1 5 1 abnormal erythrocyte osmotic lysis 0.0209818255617391 0.100888023213767 0.927579737335835 0.615384615384615 5.1 5 1 abnormal Mullerian duct morphology 0.0209818255617391 0.100888023213767 0.927579737335835 0.615384615384615 5.1 5 1 decreased bone resorption 0.0209818255617391 0.100888023213767 0.927579737335835 0.615384615384615 5.1 5 1 absent trabeculae carneae 0.0961054965701633 0.281411926734436 0.927579737335835 0.615384615384615 5.1 5 1 small trigeminal ganglion 0.0961054965701633 0.281411926734436 0.927579737335835 0.615384615384615 5.1 5 1 tight skin 0.0961054965701633 0.281411926734436 0.927579737335835 0.615384615384615 5.1 5 1 pup cannibalization 0.0961054965701633 0.281411926734436 0.927579737335835 0.615384615384615 5.1 5 1 abnormal grip strength 0.0961054965701633 0.281411926734436 0.927579737335835 0.615384615384615 5.1 5 1 abnormal otolith morphology 0.0961054965701633 0.281411926734436 0.927579737335835 0.615384615384615 5.1 5 1 abnormal bile duct development 0.0961054965701633 0.281411926734436 0.927579737335835 0.615384615384615 5.1 5 1 tracheoesophageal fistula 0.0961054965701633 0.281411926734436 0.927579737335835 0.615384615384615 5.1 5 1 muscle fatigue 0.0961054965701633 0.281411926734436 0.927579737335835 0.615384615384615 5.1 5 1 hyperalgesia 0.0961054965701633 0.281411926734436 0.927579737335835 0.615384615384615 5.1 5 1 abnormal heart development 3.71330357175491e-08 1.24822197766761e-06 0.92537820314912 0.613924050632911 5.1 5 1 abnormal blood vessel morphology 1.34801159555449e-07 4.06445920477793e-06 0.925180824222035 0.613793103448276 5.1 5 1 abnormal circadian rhythm 0.00321869284937674 0.0242254113852485 0.924944567627495 0.613636363636364 5.1 5 1 abnormal astrocyte morphology 0.00321869284937674 0.0242254113852485 0.924944567627495 0.613636363636364 5.1 5 1 abnormal neurocranium morphology 0.000140151332336874 0.00185723485261443 0.924487804878049 0.613333333333333 5.1 5 1 extramedullary hematopoiesis 6.57870606107975e-06 0.000132506326533894 0.924298205246203 0.613207547169811 5.1 5 1 osteopetrosis 0.0129808548100504 0.0704397686787555 0.923839496459481 0.612903225806452 5.1 5 1 inner cell mass degeneration 0.0129808548100504 0.0704397686787555 0.923839496459481 0.612903225806452 5.1 5 1 hemorrhage 2.60456355278912e-11 1.68281865910725e-09 0.923632589517384 0.612765957446809 5.1 5 1 reduced male fertility 6.13385863589939e-11 3.54836589693017e-09 0.922982701192651 0.612334801762115 5.1 5 1 increased sarcoma incidence 0.0020414555850228 0.0167318641441325 0.92284718765555 0.612244897959184 5.1 5 1 cataract 1.80325208941789e-06 4.25174367054692e-05 0.921830276154001 0.611570247933884 5.1 5 1 thin ventricular wall 3.77023946577179e-05 0.000633571947348554 0.921138211382114 0.611111111111111 5.1 5 1 polyphagia 0.00129932931965071 0.0115020700449507 0.921138211382114 0.611111111111111 5.1 5 1 delayed kidney development 0.0564091509412255 0.201168604876904 0.921138211382114 0.611111111111111 5.1 5 1 decreased cellular sensitivity to gamma-irradiation 0.0564091509412255 0.201168604876904 0.921138211382114 0.611111111111111 5.1 5 1 abnormal body wall morphology 0.0564091509412255 0.201168604876904 0.921138211382114 0.611111111111111 5.1 5 1 decreased activity of thyroid 0.0564091509412255 0.201168604876904 0.921138211382114 0.611111111111111 5.1 5 1 absent ureter 0.0564091509412255 0.201168604876904 0.921138211382114 0.611111111111111 5.1 5 1 absent inner cell mass 0.0564091509412255 0.201168604876904 0.921138211382114 0.611111111111111 5.1 5 1 abnormal neutrophil morphology 0.0564091509412255 0.201168604876904 0.921138211382114 0.611111111111111 5.1 5 1 abnormal pregnancy 0.0564091509412255 0.201168604876904 0.921138211382114 0.611111111111111 5.1 5 1 increased effector memory CD8-positive, alpha-beta T cell number 0.0564091509412255 0.201168604876904 0.921138211382114 0.611111111111111 5.1 5 1 abnormal metanephric mesenchyme morphology 0.0564091509412255 0.201168604876904 0.921138211382114 0.611111111111111 5.1 5 1 decreased fluid intake 0.0564091509412255 0.201168604876904 0.921138211382114 0.611111111111111 5.1 5 1 decreased heart rate 1.5791167920551e-05 0.000290667017597633 0.919463414634146 0.61 5.1 5 1 abnormal developmental patterning 9.0639760139948e-05 0.00131555641294101 0.919095776323617 0.609756097560976 5.1 5 1 increased bone trabecula number 0.00508964473559351 0.0340785178541808 0.919095776323617 0.609756097560976 5.1 5 1 decreased caudal vertebrae number 0.000530769980441278 0.00555911716356917 0.918521341463415 0.609375 5.1 5 1 atrial septal defect 0.0032144013733894 0.0242254113852485 0.917497348886532 0.608695652173913 5.1 5 1 fragile skeleton 0.0339808608169563 0.142600969940433 0.917497348886532 0.608695652173913 5.1 5 1 abnormal circulating insulin level 0.0339808608169563 0.142600969940433 0.917497348886532 0.608695652173913 5.1 5 1 failure of embryo implantation 0.0339808608169563 0.142600969940433 0.917497348886532 0.608695652173913 5.1 5 1 dilated heart 0.0339808608169563 0.142600969940433 0.917497348886532 0.608695652173913 5.1 5 1 abnormal ulna morphology 0.0339808608169563 0.142600969940433 0.917497348886532 0.608695652173913 5.1 5 1 abnormal corneal stroma morphology 0.0339808608169563 0.142600969940433 0.917497348886532 0.608695652173913 5.1 5 1 abnormal lens development 0.0339808608169563 0.142600969940433 0.917497348886532 0.608695652173913 5.1 5 1 abnormal angiogenesis 0.000218695708796245 0.00266017396396411 0.916611733684904 0.608108108108108 5.1 5 1 small seminiferous tubules 0.000218695708796245 0.00266017396396411 0.916611733684904 0.608108108108108 5.1 5 1 microphthalmia 1.37433085668841e-07 4.09418922875739e-06 0.916212338593974 0.607843137254902 5.1 5 1 increased kidney weight 0.00203870005933708 0.0167318641441325 0.916212338593974 0.607843137254902 5.1 5 1 failure of chorioallantoic fusion 0.00203870005933708 0.0167318641441325 0.916212338593974 0.607843137254902 5.1 5 1 abnormal myocardium layer morphology 0.000140739203906661 0.00185723485261443 0.915838221673356 0.607594936708861 5.1 5 1 decreased food intake 0.000140739203906661 0.00185723485261443 0.915838221673356 0.607594936708861 5.1 5 1 arrest of spermatogenesis 9.07006732942243e-05 0.00131555641294101 0.915156794425087 0.607142857142857 5.1 5 1 rib bifurcation 0.0208091441334682 0.100888023213767 0.915156794425087 0.607142857142857 5.1 5 1 lymphoid hyperplasia 0.0208091441334682 0.100888023213767 0.915156794425087 0.607142857142857 5.1 5 1 increased circulating luteinizing hormone level 0.0208091441334682 0.100888023213767 0.915156794425087 0.607142857142857 5.1 5 1 increased triglyceride level 0.0208091441334682 0.100888023213767 0.915156794425087 0.607142857142857 5.1 5 1 abnormal renal tubule epithelium morphology 0.0208091441334682 0.100888023213767 0.915156794425087 0.607142857142857 5.1 5 1 increased circulating triglyceride level 3.24752756929421e-07 8.97580536513259e-06 0.914785534062237 0.606896551724138 5.1 5 1 increased blood urea nitrogen level 3.24752756929421e-07 8.97580536513259e-06 0.914785534062237 0.606896551724138 5.1 5 1 abnormal long bone morphology 0.000828264846640719 0.00771651238209284 0.914274290283886 0.60655737704918 5.1 5 1 no abnormal phenotype detected 1.19265196357116e-71 2.96672175938326e-68 0.913946721023406 0.606340057636888 5.1 5 1 abnormal ovarian folliculogenesis 0.0128890531750414 0.0703875296880692 0.913525498891352 0.606060606060606 5.1 5 1 abnormal epidermis stratum basale morphology 0.0128890531750414 0.0703875296880692 0.913525498891352 0.606060606060606 5.1 5 1 abnormal QRS complex 0.0128890531750414 0.0703875296880692 0.913525498891352 0.606060606060606 5.1 5 1 myeloid hyperplasia 0.0128890531750414 0.0703875296880692 0.913525498891352 0.606060606060606 5.1 5 1 decreased liver weight 0.000339899093938034 0.0038344625676683 0.912882171075232 0.605633802816901 5.1 5 1 kidney failure 0.00506096188128407 0.0340785178541808 0.911401020986954 0.604651162790698 5.1 5 1 abnormal double-strand DNA break repair 0.00506096188128407 0.0340785178541808 0.911401020986954 0.604651162790698 5.1 5 1 abnormal glucose homeostasis 1.61779731294197e-08 6.0973800241563e-07 0.911015813454838 0.604395604395604 5.1 5 1 small spleen 5.8438292229561e-05 0.000907265371263659 0.911015813454838 0.604395604395604 5.1 5 1 increased thermal nociceptive threshold 5.8438292229561e-05 0.000907265371263659 0.911015813454838 0.604395604395604 5.1 5 1 abnormal bone mineralization 4.30336633175807e-06 9.18851824055639e-05 0.909373110260028 0.603305785123967 5.1 5 1 abnormal heart ventricle morphology 0.000217564598441463 0.00265941984581396 0.908255159474672 0.602564102564103 5.1 5 1 short tail 0.000140025530475572 0.00185723485261443 0.908022333235381 0.602409638554217 5.1 5 1 abnormal lipid level 0.000140025530475572 0.00185723485261443 0.908022333235381 0.602409638554217 5.1 5 1 abnormal suckling behavior 9.02482887914201e-05 0.00131555641294101 0.907815964523282 0.602272727272727 5.1 5 1 small kidney 9.02482887914201e-05 0.00131555641294101 0.907815964523282 0.602272727272727 5.1 5 1 cardiac hypertrophy 3.76246994119862e-05 0.000633571947348554 0.907466401194624 0.602040816326531 5.1 5 1 decreased circulating HDL cholesterol level 2.78468054514285e-06 6.18472576432396e-05 0.906745426829268 0.6015625 5.1 5 1 female infertility 1.7465510816511e-11 1.17420157178571e-09 0.906656886117733 0.601503759398496 5.1 5 1 increased monocyte cell number 3.74360637670913e-05 0.000633484412385304 0.904390243902439 0.6 5.1 5 1 abnormal ectoderm development 0.00501364241697245 0.0340284734303383 0.904390243902439 0.6 5.1 5 1 cardiomyopathy 0.00501364241697245 0.0340284734303383 0.904390243902439 0.6 5.1 5 1 abnormal inner ear vestibule morphology 0.0334215803448816 0.141991769612115 0.904390243902439 0.6 5.1 5 1 ruffled hair 0.0334215803448816 0.141991769612115 0.904390243902439 0.6 5.1 5 1 mandible hypoplasia 0.0334215803448816 0.141991769612115 0.904390243902439 0.6 5.1 5 1 abnormal basioccipital bone morphology 0.0552406795690251 0.201168604876904 0.904390243902439 0.6 5.1 5 1 spleen atrophy 0.0552406795690251 0.201168604876904 0.904390243902439 0.6 5.1 5 1 abnormal induced retinal neovascularization 0.0552406795690251 0.201168604876904 0.904390243902439 0.6 5.1 5 1 enhanced behavioral response to xenobiotic 0.0552406795690251 0.201168604876904 0.904390243902439 0.6 5.1 5 1 enlarged testis 0.164258808222032 0.385697839433079 0.904390243902439 0.6 5.1 5 1 abnormal epidermis suprabasal layer morphology 0.164258808222032 0.385697839433079 0.904390243902439 0.6 5.1 5 1 abnormal optic nerve innervation 0.164258808222032 0.385697839433079 0.904390243902439 0.6 5.1 5 1 abnormal grooming behavior 0.164258808222032 0.385697839433079 0.904390243902439 0.6 5.1 5 1 alcohol preference 0.164258808222032 0.385697839433079 0.904390243902439 0.6 5.1 5 1 abnormal gland morphology 0.164258808222032 0.385697839433079 0.904390243902439 0.6 5.1 5 1 aneurysm 0.164258808222032 0.385697839433079 0.904390243902439 0.6 5.1 5 1 intestinal hypoperistalsis 0.164258808222032 0.385697839433079 0.904390243902439 0.6 5.1 5 1 abnormal submandibular gland morphology 0.164258808222032 0.385697839433079 0.904390243902439 0.6 5.1 5 1 increased atrioventricular cushion size 0.164258808222032 0.385697839433079 0.904390243902439 0.6 5.1 5 1 increased left ventricle diastolic pressure 0.164258808222032 0.385697839433079 0.904390243902439 0.6 5.1 5 1 abnormal reproductive system development 0.164258808222032 0.385697839433079 0.904390243902439 0.6 5.1 5 1 abnormal embryonic erythrocyte morphology 0.164258808222032 0.385697839433079 0.904390243902439 0.6 5.1 5 1 abnormal deltoid tuberosity morphology 0.164258808222032 0.385697839433079 0.904390243902439 0.6 5.1 5 1 abnormal respiratory conducting tube morphology 0.164258808222032 0.385697839433079 0.904390243902439 0.6 5.1 5 1 decreased cochlear inner hair cell number 0.164258808222032 0.385697839433079 0.904390243902439 0.6 5.1 5 1 decreased prolactin level 0.164258808222032 0.385697839433079 0.904390243902439 0.6 5.1 5 1 abnormal corneal endothelium morphology 0.164258808222032 0.385697839433079 0.904390243902439 0.6 5.1 5 1 abnormal gonadal fat pad morphology 0.164258808222032 0.385697839433079 0.904390243902439 0.6 5.1 5 1 tachypnea 0.164258808222032 0.385697839433079 0.904390243902439 0.6 5.1 5 1 protruding tongue 0.164258808222032 0.385697839433079 0.904390243902439 0.6 5.1 5 1 increased serotonin level 0.164258808222032 0.385697839433079 0.904390243902439 0.6 5.1 5 1 umbilical hernia 0.164258808222032 0.385697839433079 0.904390243902439 0.6 5.1 5 1 increased T-helper 17 cell number 0.164258808222032 0.385697839433079 0.904390243902439 0.6 5.1 5 1 aorta stenosis 0.164258808222032 0.385697839433079 0.904390243902439 0.6 5.1 5 1 increased compact bone area 0.164258808222032 0.385697839433079 0.904390243902439 0.6 5.1 5 1 abnormal adaptive thermogenesis 0.164258808222032 0.385697839433079 0.904390243902439 0.6 5.1 5 1 decreased macrophage apoptosis 0.164258808222032 0.385697839433079 0.904390243902439 0.6 5.1 5 1 impaired fertilization 0.00052447818361054 0.00550480793979417 0.904390243902439 0.6 5.1 5 1 holoprosencephaly 0.0127368137476751 0.0698628978993204 0.904390243902439 0.6 5.1 5 1 decreased glycogen level 0.0127368137476751 0.0698628978993204 0.904390243902439 0.6 5.1 5 1 impaired adaptive thermogenesis 0.0127368137476751 0.0698628978993204 0.904390243902439 0.6 5.1 5 1 decreased bone mineralization 0.0127368137476751 0.0698628978993204 0.904390243902439 0.6 5.1 5 1 epidermal hyperplasia 0.00128230614223702 0.0114532729939482 0.904390243902439 0.6 5.1 5 1 intracranial hemorrhage 0.00128230614223702 0.0114532729939482 0.904390243902439 0.6 5.1 5 1 abnormal long bone epiphyseal plate morphology 0.00128230614223702 0.0114532729939482 0.904390243902439 0.6 5.1 5 1 increased circulating calcium level 0.00201302102113756 0.0166358464786701 0.904390243902439 0.6 5.1 5 1 delayed eyelid opening 0.0205237012323874 0.100888023213767 0.904390243902439 0.6 5.1 5 1 abnormal fontanelle morphology 0.0934005282937376 0.281411926734436 0.904390243902439 0.6 5.1 5 1 abnormal epidermis stratum spinosum morphology 0.0934005282937376 0.281411926734436 0.904390243902439 0.6 5.1 5 1 abnormal bronchus morphology 0.0934005282937376 0.281411926734436 0.904390243902439 0.6 5.1 5 1 arthritis 0.0934005282937376 0.281411926734436 0.904390243902439 0.6 5.1 5 1 abnormal trophectoderm morphology 0.0934005282937376 0.281411926734436 0.904390243902439 0.6 5.1 5 1 abnormal Muller cell morphology 0.0934005282937376 0.281411926734436 0.904390243902439 0.6 5.1 5 1 decreased thymocyte apoptosis 0.0934005282937376 0.281411926734436 0.904390243902439 0.6 5.1 5 1 lactation failure 0.0934005282937376 0.281411926734436 0.904390243902439 0.6 5.1 5 1 decreased trabecular bone mass 0.0934005282937376 0.281411926734436 0.904390243902439 0.6 5.1 5 1 abnormal branching involved in lung morphogenesis 0.0934005282937376 0.281411926734436 0.904390243902439 0.6 5.1 5 1 short limbs 0.000138210438489503 0.00185336100130803 0.900925147182506 0.597701149425287 5.1 5 1 sparse hair 0.000214615224845697 0.00264284837526569 0.900713860797145 0.597560975609756 5.1 5 1 obese 0.000333762065392769 0.00377378698938415 0.900475134621476 0.597402597402597 5.1 5 1 rib fusion 0.000811599158305573 0.00764460713568019 0.899890789952676 0.597014925373134 5.1 5 1 increased hepatocellular carcinoma incidence 0.0019917745657091 0.0164876513550795 0.899101412066752 0.596491228070175 5.1 5 1 increased percent body fat/body weight 0.00313424469517545 0.0238004908354831 0.89859287054409 0.596153846153846 5.1 5 1 abnormal tibia morphology 0.0049506266885747 0.0336927055754571 0.897976128697457 0.595744680851064 5.1 5 1 hepatic necrosis 0.0049506266885747 0.0336927055754571 0.897976128697457 0.595744680851064 5.1 5 1 decreased rib number 0.000136949188490218 0.00184640166053885 0.897615785146616 0.595505617977528 5.1 5 1 abnormal muscle morphology 0.00785556137298205 0.0486692625536559 0.897212543554007 0.595238095238095 5.1 5 1 abnormal intestine morphology 0.000514416509235553 0.00543077607652045 0.896242584047462 0.594594594594595 5.1 5 1 abnormal long bone metaphysis morphology 0.0125362232732143 0.0694517937463708 0.896242584047462 0.594594594594595 5.1 5 1 skin inflammation 0.0125362232732143 0.0694517937463708 0.896242584047462 0.594594594594595 5.1 5 1 abnormal respiratory electron transport chain 0.0125362232732143 0.0694517937463708 0.896242584047462 0.594594594594595 5.1 5 1 thymus hypoplasia 2.69284084508928e-06 6.06193810150188e-05 0.895652173913044 0.594202898550725 5.1 5 1 abnormal sternum morphology 0.000802426460062744 0.00760394597868981 0.895652173913044 0.594202898550725 5.1 5 1 microcephaly 0.000802426460062744 0.00760394597868981 0.895652173913044 0.594202898550725 5.1 5 1 increased dopamine level 0.0201515825224147 0.0996561859334128 0.894969512195122 0.59375 5.1 5 1 abnormal lumbar vertebrae morphology 0.0201515825224147 0.0996561859334128 0.894969512195122 0.59375 5.1 5 1 abnormal spongiotrophoblast layer morphology 0.0201515825224147 0.0996561859334128 0.894969512195122 0.59375 5.1 5 1 increased oxygen consumption 0.000210174706009407 0.0026075290832838 0.893874078275667 0.593023255813954 5.1 5 1 abnormal skeleton development 0.000326497877241134 0.00371699528438133 0.893224932249323 0.592592592592593 5.1 5 1 abnormal long bone epiphyseal plate proliferative zone 0.00309016780900907 0.0235070104737311 0.893224932249322 0.592592592592593 5.1 5 1 abnormal heart valve morphology 0.0327047092750406 0.140870933890326 0.893224932249322 0.592592592592593 5.1 5 1 thin epidermis 0.0327047092750406 0.140870933890326 0.893224932249322 0.592592592592593 5.1 5 1 abnormal type II pneumocyte morphology 0.0327047092750406 0.140870933890326 0.893224932249322 0.592592592592593 5.1 5 1 abnormal fetal cardiomyocyte proliferation 0.0327047092750406 0.140870933890326 0.893224932249322 0.592592592592593 5.1 5 1 polydactyly 8.64202370280953e-05 0.00127201384383069 0.892085614733699 0.591836734693878 5.1 5 1 abnormal craniofacial development 0.00487450328882072 0.0334491777405284 0.892085614733699 0.591836734693878 5.1 5 1 increased circulating cholesterol level 1.96260815886906e-07 5.64391652622751e-06 0.890687361419069 0.590909090909091 5.1 5 1 hypertension 0.00772201714959472 0.048262607184967 0.890687361419069 0.590909090909091 5.1 5 1 abnormal abdominal fat pad morphology 0.0537839623647779 0.199123131090805 0.890687361419069 0.590909090909091 5.1 5 1 abnormal enterocyte morphology 0.0537839623647779 0.199123131090805 0.890687361419069 0.590909090909091 5.1 5 1 intestinal inflammation 0.0537839623647779 0.199123131090805 0.890687361419069 0.590909090909091 5.1 5 1 abnormal chorion morphology 0.0537839623647779 0.199123131090805 0.890687361419069 0.590909090909091 5.1 5 1 increased myocardial infarction size 0.0537839623647779 0.199123131090805 0.890687361419069 0.590909090909091 5.1 5 1 abnormal cochlear sensory epithelium morphology 0.0537839623647779 0.199123131090805 0.890687361419069 0.590909090909091 5.1 5 1 abnormal retinal outer plexiform layer morphology 0.0537839623647779 0.199123131090805 0.890687361419069 0.590909090909091 5.1 5 1 abnormal basement membrane morphology 0.0537839623647779 0.199123131090805 0.890687361419069 0.590909090909091 5.1 5 1 failure of palatal shelf elevation 0.0537839623647779 0.199123131090805 0.890687361419069 0.590909090909091 5.1 5 1 increased circulating creatine kinase level 0.0537839623647779 0.199123131090805 0.890687361419069 0.590909090909091 5.1 5 1 increased osteoclast cell number 0.00193612560789567 0.0160537081654683 0.889564174330268 0.590163934426229 5.1 5 1 increased body weight 6.15015721573644e-09 2.52868034283378e-07 0.888240418118467 0.589285714285714 5.1 5 1 circling 0.000317302812335113 0.00362059975084217 0.886657101865136 0.588235294117647 5.1 5 1 abnormal trophoblast layer morphology 0.0047875432778373 0.0328978284630395 0.886657101865136 0.588235294117647 5.1 5 1 overexpanded pulmonary alveoli 0.0197136486690156 0.0980668515615455 0.886657101865136 0.588235294117647 5.1 5 1 increased width of hypertrophic chondrocyte zone 0.0197136486690156 0.0980668515615455 0.886657101865136 0.588235294117647 5.1 5 1 increased susceptibility to weight gain 0.0197136486690156 0.0980668515615455 0.886657101865136 0.588235294117647 5.1 5 1 distended urinary bladder 0.0901894254668512 0.275948580379819 0.886657101865136 0.588235294117647 5.1 5 1 abnormal vagus nerve morphology 0.0901894254668512 0.275948580379819 0.886657101865136 0.588235294117647 5.1 5 1 increased incidence of corneal inflammation 0.0901894254668512 0.275948580379819 0.886657101865136 0.588235294117647 5.1 5 1 decreased vasoconstriction 0.0901894254668512 0.275948580379819 0.886657101865136 0.588235294117647 5.1 5 1 decreased circulating glucose level 1.25470031035753e-10 6.8594879604711e-09 0.886021505376344 0.587813620071685 5.1 5 1 decreased susceptibility to hepatic steatosis 0.00190298511678632 0.0158582093065527 0.885249709639954 0.587301587301587 5.1 5 1 abnormal middle ear morphology 0.0318753139004267 0.137775574851975 0.883599663582843 0.586206896551724 5.1 5 1 abnormal outer ear morphology 0.0318753139004267 0.137775574851975 0.883599663582843 0.586206896551724 5.1 5 1 abnormal lens morphology 1.41869394265008e-05 0.000266339711874873 0.883193597560976 0.5859375 5.1 5 1 dehydration 0.00119538781642621 0.0108721286777338 0.882857142857143 0.585714285714286 5.1 5 1 scaly skin 0.012028601749116 0.0671414961383204 0.882331945270672 0.585365853658537 5.1 5 1 liver fibrosis 0.012028601749116 0.0671414961383204 0.882331945270672 0.585365853658537 5.1 5 1 abnormal placenta development 0.00469173332218383 0.0325088764315662 0.881638288080994 0.584905660377358 5.1 5 1 anophthalmia 0.00030662627092298 0.00355316091595237 0.880679638257057 0.584269662921348 5.1 5 1 decreased T cell number 1.55361020123425e-06 3.69818696226814e-05 0.880048477503409 0.583850931677019 5.1 5 1 retinal degeneration 0.000194411644165944 0.00247365199418305 0.879268292682927 0.583333333333333 5.1 5 1 abnormal osteoclast morphology 0.00740458183137707 0.0469869829223226 0.879268292682927 0.583333333333333 5.1 5 1 abnormal tumor morphology 0.0521414048814492 0.197565490697037 0.879268292682927 0.583333333333333 5.1 5 1 abnormal inner cell mass apoptosis 0.0521414048814492 0.197565490697037 0.879268292682927 0.583333333333333 5.1 5 1 abnormal rectum morphology 0.156117424616716 0.385697839433079 0.879268292682927 0.583333333333333 5.1 5 1 absent optic nerve 0.156117424616716 0.385697839433079 0.879268292682927 0.583333333333333 5.1 5 1 increased litter size 0.156117424616716 0.385697839433079 0.879268292682927 0.583333333333333 5.1 5 1 decreased circulating ketone body level 0.156117424616716 0.385697839433079 0.879268292682927 0.583333333333333 5.1 5 1 abnormal nucleotide metabolism 0.156117424616716 0.385697839433079 0.879268292682927 0.583333333333333 5.1 5 1 vestibular saccular macula degeneration 0.156117424616716 0.385697839433079 0.879268292682927 0.583333333333333 5.1 5 1 absent cochlear hair cells 0.156117424616716 0.385697839433079 0.879268292682927 0.583333333333333 5.1 5 1 abnormal B cell proliferation 0.156117424616716 0.385697839433079 0.879268292682927 0.583333333333333 5.1 5 1 abnormal anogenital distance 0.156117424616716 0.385697839433079 0.879268292682927 0.583333333333333 5.1 5 1 abnormal palatine bone morphology 0.156117424616716 0.385697839433079 0.879268292682927 0.583333333333333 5.1 5 1 decreased renal glomerular filtration rate 0.156117424616716 0.385697839433079 0.879268292682927 0.583333333333333 5.1 5 1 abnormal thymus corticomedullary boundary morphology 0.156117424616716 0.385697839433079 0.879268292682927 0.583333333333333 5.1 5 1 decreased keratinocyte proliferation 0.156117424616716 0.385697839433079 0.879268292682927 0.583333333333333 5.1 5 1 impaired behavioral response to cocaine 0.156117424616716 0.385697839433079 0.879268292682927 0.583333333333333 5.1 5 1 increased fibrosarcoma incidence 0.156117424616716 0.385697839433079 0.879268292682927 0.583333333333333 5.1 5 1 abnormal pulmonary valve cusp morphology 0.156117424616716 0.385697839433079 0.879268292682927 0.583333333333333 5.1 5 1 increased type II pneumocyte number 0.156117424616716 0.385697839433079 0.879268292682927 0.583333333333333 5.1 5 1 abnormal respiratory motile cilium morphology 0.156117424616716 0.385697839433079 0.879268292682927 0.583333333333333 5.1 5 1 abnormal eye physiology 0.00292298360685835 0.0225454937118144 0.879268292682927 0.583333333333333 5.1 5 1 abnormal uterus morphology 0.0192266214385794 0.09632672875824 0.879268292682927 0.583333333333333 5.1 5 1 renal hypoplasia 0.0192266214385794 0.09632672875824 0.879268292682927 0.583333333333333 5.1 5 1 head tilt 0.0192266214385794 0.09632672875824 0.879268292682927 0.583333333333333 5.1 5 1 abnormal kidney morphology 6.39214297400479e-07 1.6993563191131e-05 0.878550522648084 0.582857142857143 5.1 5 1 abnormal skeleton morphology 5.09277925312879e-05 0.000817308928526313 0.878176033934252 0.582608695652174 5.1 5 1 abnormal placenta labyrinth morphology 0.000738314871518839 0.0071880948841609 0.8776782957703 0.582278481012658 5.1 5 1 decreased circulating calcium level 0.00458880681822164 0.0318845166489563 0.876984478935698 0.581818181818182 5.1 5 1 abnormal joint morphology 0.00458880681822164 0.0318845166489563 0.876984478935698 0.581818181818182 5.1 5 1 spleen hypoplasia 0.000121067584773864 0.00168714631442569 0.875679442508711 0.580952380952381 5.1 5 1 abnormal eyelid morphology 0.0309676424325463 0.135739225640456 0.875216365066876 0.580645161290323 5.1 5 1 abnormal mitochondrial ATP synthesis coupled electron transport 0.0309676424325463 0.135739225640456 0.875216365066876 0.580645161290323 5.1 5 1 abnormal neuron differentiation 7.6964753584561e-05 0.00114984879604562 0.874782229965157 0.580357142857143 5.1 5 1 enlarged spleen 3.68199601754888e-10 1.88844641106244e-08 0.874034552845528 0.579861111111111 5.1 5 1 hyperkeratosis 0.00178861672838632 0.0151332792920441 0.873806998939555 0.579710144927536 5.1 5 1 increased bone marrow cell number 0.0187039309970261 0.0939919764749542 0.872657252888318 0.578947368421053 5.1 5 1 abnormal retinal outer nuclear layer morphology 0.0187039309970261 0.0939919764749542 0.872657252888318 0.578947368421053 5.1 5 1 short vibrissae 0.0867163517631902 0.267129318898992 0.872657252888318 0.578947368421053 5.1 5 1 abnormal nasal septum morphology 0.0867163517631902 0.267129318898992 0.872657252888318 0.578947368421053 5.1 5 1 maternal imprinting 0.0867163517631902 0.267129318898992 0.872657252888318 0.578947368421053 5.1 5 1 decreased eye pigmentation 0.0867163517631902 0.267129318898992 0.872657252888318 0.578947368421053 5.1 5 1 decreased liver regeneration 0.0867163517631902 0.267129318898992 0.872657252888318 0.578947368421053 5.1 5 1 decreased circulating magnesium level 0.0867163517631902 0.267129318898992 0.872657252888318 0.578947368421053 5.1 5 1 abnormal vertebrae morphology 0.000116107307038272 0.00162332469005693 0.87120161109868 0.577981651376147 5.1 5 1 trabecula carnea hypoplasia 0.0114282141521304 0.0655771227299292 0.87089430894309 0.577777777777778 5.1 5 1 corneal opacity 0.00174695834631329 0.0148820509810079 0.870422535211268 0.577464788732394 5.1 5 1 increased rib number 0.00109694470375293 0.0100502760610881 0.869606003752345 0.576923076923077 5.1 5 1 heart inflammation 0.0503848823218942 0.191493345723013 0.869606003752345 0.576923076923077 5.1 5 1 increased leukemia incidence 0.0503848823218942 0.191493345723013 0.869606003752345 0.576923076923077 5.1 5 1 increased thymocyte apoptosis 0.0503848823218942 0.191493345723013 0.869606003752345 0.576923076923077 5.1 5 1 decreased litter size 1.20442638699075e-09 5.70668692883713e-08 0.86898706709487 0.576512455516014 5.1 5 1 cardiac fibrosis 0.000690781946544125 0.00688705447706818 0.868923959827834 0.576470588235294 5.1 5 1 increased hemoglobin content 0.00436744069870102 0.0306460049027328 0.868623398098388 0.576271186440678 5.1 5 1 deafness 0.000275857891254168 0.00324442791723282 0.867849223946785 0.575757575757576 5.1 5 1 abnormal middle ear ossicle morphology 0.0300078723509928 0.131997493321122 0.867849223946785 0.575757575757576 5.1 5 1 head tossing 0.0300078723509928 0.131997493321122 0.867849223946785 0.575757575757576 5.1 5 1 increased bone mineral density 0.000110966245879922 0.00156834395810401 0.867040794301748 0.575221238938053 5.1 5 1 abnormal female reproductive system morphology 0.0181563784025029 0.0939848278008398 0.866707317073171 0.575 5.1 5 1 cleft secondary palate 0.000425649875098794 0.00472680385851898 0.865905552672548 0.574468085106383 5.1 5 1 increased systemic arterial blood pressure 0.0111072317669067 0.0645613467551686 0.865905552672548 0.574468085106383 5.1 5 1 abnormal T-helper 1 physiology 0.0111072317669067 0.0645613467551686 0.865905552672548 0.574468085106383 5.1 5 1 abnormal pulmonary alveolus morphology 0.000269302954934344 0.00317483933838475 0.865588022216856 0.574257425742574 5.1 5 1 abnormal male meiosis 0.00425144629776964 0.0298742165697796 0.864854058376649 0.573770491803279 5.1 5 1 decreased neutrophil cell number 0.000105725236967729 0.00149852721912949 0.863164477798624 0.572649572649573 5.1 5 1 improved glucose tolerance 7.42402510678551e-07 1.87484898001309e-05 0.861324041811847 0.571428571428571 5.1 5 1 increased circulating LDL cholesterol level 0.0107780198881189 0.0629350339711168 0.861324041811847 0.571428571428571 5.1 5 1 abnormal B cell differentiation 0.000640282306521841 0.00643516055544679 0.861324041811847 0.571428571428571 5.1 5 1 increased circulating aspartate transaminase level 0.00413327012915967 0.0291674026844955 0.861324041811847 0.571428571428571 5.1 5 1 abnormal spleen white pulp morphology 0.0175926555839613 0.0915517380023091 0.861324041811847 0.571428571428571 5.1 5 1 abnormal hematopoietic system physiology 0.0831311685570776 0.266314807941775 0.861324041811847 0.571428571428571 5.1 5 1 abnormal associative learning 0.0831311685570776 0.266314807941775 0.861324041811847 0.571428571428571 5.1 5 1 decreased cochlear outer hair cell number 0.0831311685570776 0.266314807941775 0.861324041811847 0.571428571428571 5.1 5 1 vascular ring 0.0831311685570776 0.266314807941775 0.861324041811847 0.571428571428571 5.1 5 1 increased bone ossification 0.0831311685570776 0.266314807941775 0.861324041811847 0.571428571428571 5.1 5 1 abnormal heart morphology 8.04909625831539e-08 2.55058941943434e-06 0.861324041811847 0.571428571428571 5.1 5 1 abnormal lung morphology 0.000103088891733183 0.00146533496106453 0.861324041811847 0.571428571428571 5.1 5 1 short mandible 0.00665446499029244 0.0427725624376032 0.861324041811847 0.571428571428571 5.1 5 1 abnormal seminal vesicle morphology 0.00665446499029244 0.0427725624376032 0.861324041811847 0.571428571428571 5.1 5 1 thick pulmonary interalveolar septum 0.029016095230803 0.127861004227852 0.861324041811847 0.571428571428571 5.1 5 1 abnormal artery morphology 0.029016095230803 0.127861004227852 0.861324041811847 0.571428571428571 5.1 5 1 decreased bone volume 0.029016095230803 0.127861004227852 0.861324041811847 0.571428571428571 5.1 5 1 abnormal respiration 0.048565462797137 0.187061305256002 0.861324041811847 0.571428571428571 5.1 5 1 failure of blastocyst to hatch from the zona pellucida 0.048565462797137 0.187061305256002 0.861324041811847 0.571428571428571 5.1 5 1 decreased circulating progesterone level 0.048565462797137 0.187061305256002 0.861324041811847 0.571428571428571 5.1 5 1 corneal vascularization 0.048565462797137 0.187061305256002 0.861324041811847 0.571428571428571 5.1 5 1 abnormal kidney blood vessel morphology 0.147957093095656 0.385697839433079 0.861324041811847 0.571428571428571 5.1 5 1 irregularly shaped pupil 0.147957093095656 0.385697839433079 0.861324041811847 0.571428571428571 5.1 5 1 abnormal olfactory system physiology 0.147957093095656 0.385697839433079 0.861324041811847 0.571428571428571 5.1 5 1 abnormal endplate potential 0.147957093095656 0.385697839433079 0.861324041811847 0.571428571428571 5.1 5 1 increased lactate dehydrogenase level 0.147957093095656 0.385697839433079 0.861324041811847 0.571428571428571 5.1 5 1 absent otoliths 0.147957093095656 0.385697839433079 0.861324041811847 0.571428571428571 5.1 5 1 abnormal ventral body wall morphology 0.147957093095656 0.385697839433079 0.861324041811847 0.571428571428571 5.1 5 1 abnormal imprinting 0.147957093095656 0.385697839433079 0.861324041811847 0.571428571428571 5.1 5 1 abnormal maternal decidual layer morphology 0.147957093095656 0.385697839433079 0.861324041811847 0.571428571428571 5.1 5 1 abnormal squamosal bone morphology 0.147957093095656 0.385697839433079 0.861324041811847 0.571428571428571 5.1 5 1 abnormal glucose tolerance 0.147957093095656 0.385697839433079 0.861324041811847 0.571428571428571 5.1 5 1 decreased cornea thickness 0.147957093095656 0.385697839433079 0.861324041811847 0.571428571428571 5.1 5 1 pulmonary alveolar hemorrhage 0.147957093095656 0.385697839433079 0.861324041811847 0.571428571428571 5.1 5 1 decreased compact bone area 0.147957093095656 0.385697839433079 0.861324041811847 0.571428571428571 5.1 5 1 abnormal liver physiology 0.000393821781283834 0.00441275531956549 0.859170731707317 0.57 5.1 5 1 decreased monocyte cell number 0.00401375736005762 0.0284233572505374 0.858011257035647 0.569230769230769 5.1 5 1 abnormal enzyme/coenzyme level 0.00645599313297525 0.0416043598919065 0.857611438183347 0.568965517241379 5.1 5 1 abnormal gastrulation 0.0104439104382333 0.0610557631377328 0.857101865136298 0.568627450980392 5.1 5 1 abnormal myelopoiesis 0.0170197553536605 0.0891612066692511 0.856430155210643 0.568181818181818 5.1 5 1 decreased B cell number 6.53893966419949e-07 1.71216972786276e-05 0.85609756097561 0.567961165048544 5.1 5 1 malocclusion 0.0280077690306212 0.125304542200846 0.855504284772577 0.567567567567568 5.1 5 1 abnormal hair follicle development 0.0280077690306212 0.125304542200846 0.855504284772577 0.567567567567568 5.1 5 1 abnormal hair cycle 0.0467197304663242 0.184322489349693 0.854146341463415 0.566666666666667 5.1 5 1 abnormal microglial cell physiology 0.0467197304663242 0.184322489349693 0.854146341463415 0.566666666666667 5.1 5 1 liver hemorrhage 0.0467197304663242 0.184322489349693 0.854146341463415 0.566666666666667 5.1 5 1 abnormal coat/ hair morphology 0.0101076605054334 0.0592292238098131 0.853198343304188 0.566037735849057 5.1 5 1 abnormal mesoderm development 0.0101076605054334 0.0592292238098131 0.853198343304188 0.566037735849057 5.1 5 1 weight loss 5.75133075365887e-06 0.000118235002063855 0.852710801393728 0.565714285714286 5.1 5 1 abnormal inner ear morphology 0.0164432963220586 0.0867501582208287 0.851961823966066 0.565217391304348 5.1 5 1 abnormal pulmonary artery morphology 0.0795279943769459 0.257250827064568 0.851961823966066 0.565217391304348 5.1 5 1 abnormal innervation pattern to muscle 0.0795279943769459 0.257250827064568 0.851961823966066 0.565217391304348 5.1 5 1 abnormal cardiovascular development 0.0795279943769459 0.257250827064568 0.851961823966066 0.565217391304348 5.1 5 1 abnormal vertebral artery topology 0.0795279943769459 0.257250827064568 0.851961823966066 0.565217391304348 5.1 5 1 increased circulating alanine transaminase level 0.002288198244638 0.0185706138125188 0.850281425891182 0.564102564102564 5.1 5 1 small lens 0.0269947934803035 0.121208571809125 0.850281425891182 0.564102564102564 5.1 5 1 abnormal retinal pigment epithelium morphology 0.00221610092978782 0.0180148727544027 0.847865853658537 0.5625 5.1 5 1 abnormal tooth morphology 0.00585804382001801 0.0379970899668704 0.847865853658537 0.5625 5.1 5 1 decreased eosinophil cell number 0.00585804382001801 0.0379970899668704 0.847865853658537 0.5625 5.1 5 1 abnormal heart atrium morphology 0.0448740051741442 0.177462778808718 0.847865853658537 0.5625 5.1 5 1 abnormal serotonin level 0.0448740051741442 0.177462778808718 0.847865853658537 0.5625 5.1 5 1 vasculature congestion 0.140019875196048 0.385697839433079 0.847865853658537 0.5625 5.1 5 1 abnormal hair follicle orientation 0.140019875196048 0.385697839433079 0.847865853658537 0.5625 5.1 5 1 delayed hair appearance 0.140019875196048 0.385697839433079 0.847865853658537 0.5625 5.1 5 1 abnormal mouth morphology 0.140019875196048 0.385697839433079 0.847865853658537 0.5625 5.1 5 1 disorganized yolk sac vascular plexus 0.140019875196048 0.385697839433079 0.847865853658537 0.5625 5.1 5 1 abnormal olfaction 0.140019875196048 0.385697839433079 0.847865853658537 0.5625 5.1 5 1 impaired muscle relaxation 0.140019875196048 0.385697839433079 0.847865853658537 0.5625 5.1 5 1 large intestinal inflammation 0.140019875196048 0.385697839433079 0.847865853658537 0.5625 5.1 5 1 small pancreas 0.140019875196048 0.385697839433079 0.847865853658537 0.5625 5.1 5 1 small epididymis 0.140019875196048 0.385697839433079 0.847865853658537 0.5625 5.1 5 1 abnormal amnion morphology 0.140019875196048 0.385697839433079 0.847865853658537 0.5625 5.1 5 1 decreased circulating prolactin level 0.140019875196048 0.385697839433079 0.847865853658537 0.5625 5.1 5 1 abnormal Langerhans cell physiology 0.140019875196048 0.385697839433079 0.847865853658537 0.5625 5.1 5 1 abnormal pulmonary alveolus wall morphology 0.140019875196048 0.385697839433079 0.847865853658537 0.5625 5.1 5 1 decreased adipocyte glucose uptake 0.140019875196048 0.385697839433079 0.847865853658537 0.5625 5.1 5 1 abnormal eye electrophysiology 0.000203671494379878 0.00256169067505689 0.847087280790163 0.56198347107438 5.1 5 1 abnormal lipid homeostasis 0.000125621041323235 0.00173601300161971 0.846416510318949 0.561538461538462 5.1 5 1 short humerus 0.025986315237386 0.116891427039779 0.845568114217728 0.560975609756098 5.1 5 1 hemopericardium 0.025986315237386 0.116891427039779 0.845568114217728 0.560975609756098 5.1 5 1 abnormal skin morphology 0.00566120004773076 0.0372053767998158 0.845011086474501 0.560606060606061 5.1 5 1 increased body length 0.0152968063664416 0.0811317821674274 0.84409756097561 0.56 5.1 5 1 abnormal primitive streak morphology 0.0759666361098081 0.246532299182189 0.84409756097561 0.56 5.1 5 1 abnormal preimplantation embryo development 0.0759666361098081 0.246532299182189 0.84409756097561 0.56 5.1 5 1 increased food intake 0.00207442826192499 0.0169741457287448 0.843379790940767 0.55952380952381 5.1 5 1 kinked tail 0.00077296058903457 0.00743806369525529 0.842324246771879 0.558823529411765 5.1 5 1 decreased circulating alanine transaminase level 0.00546685323236568 0.0365068386993547 0.842324246771879 0.558823529411765 5.1 5 1 abnormal retinal photoreceptor morphology 0.0430472223481639 0.170645363491726 0.842324246771879 0.558823529411765 5.1 5 1 abnormal oocyte morphology 0.0430472223481639 0.170645363491726 0.842324246771879 0.558823529411765 5.1 5 1 abnormal spleen red pulp morphology 0.0430472223481639 0.170645363491726 0.842324246771879 0.558823529411765 5.1 5 1 decreased pancreatic beta cell number 0.0430472223481639 0.170645363491726 0.842324246771879 0.558823529411765 5.1 5 1 abnormal liver morphology 1.07458098146308e-05 0.000207210867549567 0.842076577190353 0.558659217877095 5.1 5 1 abnormal homeostasis 0.0249893368825702 0.113991163389814 0.841293250141804 0.558139534883721 5.1 5 1 cachexia 0.000747628329075768 0.00720854925567602 0.8406191369606 0.557692307692308 5.1 5 1 abnormal spleen morphology 1.62510721626656e-05 0.000296150490876415 0.840285954583684 0.557471264367816 5.1 5 1 abnormal cartilage development 0.0240091818555733 0.113991163389814 0.83739837398374 0.555555555555556 5.1 5 1 abnormal cell migration 0.0240091818555733 0.113991163389814 0.83739837398374 0.555555555555556 5.1 5 1 wrinkled skin 0.0724850986304611 0.235849160030441 0.83739837398374 0.555555555555556 5.1 5 1 abnormal palate morphology 0.0724850986304611 0.235849160030441 0.83739837398374 0.555555555555556 5.1 5 1 decreased bone ossification 0.0724850986304611 0.235849160030441 0.83739837398374 0.555555555555556 5.1 5 1 abnormal retinal blood vessel morphology 0.0412529374710822 0.164186691134907 0.83739837398374 0.555555555555556 5.1 5 1 lowered ear position 0.132414768623883 0.370299872908274 0.83739837398374 0.555555555555556 5.1 5 1 abnormal heart shape 0.132414768623883 0.370299872908274 0.83739837398374 0.555555555555556 5.1 5 1 right pulmonary isomerism 0.132414768623883 0.370299872908274 0.83739837398374 0.555555555555556 5.1 5 1 abnormal retinal rod cell morphology 0.132414768623883 0.370299872908274 0.83739837398374 0.555555555555556 5.1 5 1 blepharoptosis 0.132414768623883 0.370299872908274 0.83739837398374 0.555555555555556 5.1 5 1 eye inflammation 0.132414768623883 0.370299872908274 0.83739837398374 0.555555555555556 5.1 5 1 abnormal thyroid cartilage morphology 0.132414768623883 0.370299872908274 0.83739837398374 0.555555555555556 5.1 5 1 absent allantois 0.132414768623883 0.370299872908274 0.83739837398374 0.555555555555556 5.1 5 1 abnormal redox activity 0.132414768623883 0.370299872908274 0.83739837398374 0.555555555555556 5.1 5 1 decreased heart rate variability 0.132414768623883 0.370299872908274 0.83739837398374 0.555555555555556 5.1 5 1 abnormal glycogen homeostasis 0.132414768623883 0.370299872908274 0.83739837398374 0.555555555555556 5.1 5 1 abnormal sperm axoneme morphology 0.132414768623883 0.370299872908274 0.83739837398374 0.555555555555556 5.1 5 1 increased gastrointestinal tumor incidence 0.132414768623883 0.370299872908274 0.83739837398374 0.555555555555556 5.1 5 1 heart hyperplasia 0.264107691250221 0.540714306160432 0.83739837398374 0.555555555555556 5.1 5 1 renal tubular acidosis 0.264107691250221 0.540714306160432 0.83739837398374 0.555555555555556 5.1 5 1 synostosis 0.264107691250221 0.540714306160432 0.83739837398374 0.555555555555556 5.1 5 1 abnormal sympathetic neuron morphology 0.264107691250221 0.540714306160432 0.83739837398374 0.555555555555556 5.1 5 1 small nodose ganglion 0.264107691250221 0.540714306160432 0.83739837398374 0.555555555555556 5.1 5 1 psoriasis 0.264107691250221 0.540714306160432 0.83739837398374 0.555555555555556 5.1 5 1 multifocal hepatic necrosis 0.264107691250221 0.540714306160432 0.83739837398374 0.555555555555556 5.1 5 1 decreased level of surface class I molecules 0.264107691250221 0.540714306160432 0.83739837398374 0.555555555555556 5.1 5 1 abnormal laryngeal cartilage morphology 0.264107691250221 0.540714306160432 0.83739837398374 0.555555555555556 5.1 5 1 abnormal posterior semicircular canal morphology 0.264107691250221 0.540714306160432 0.83739837398374 0.555555555555556 5.1 5 1 decreased circulating bicarbonate level 0.264107691250221 0.540714306160432 0.83739837398374 0.555555555555556 5.1 5 1 yellow coat color 0.264107691250221 0.540714306160432 0.83739837398374 0.555555555555556 5.1 5 1 abnormal lens capsule morphology 0.264107691250221 0.540714306160432 0.83739837398374 0.555555555555556 5.1 5 1 priapism 0.264107691250221 0.540714306160432 0.83739837398374 0.555555555555556 5.1 5 1 abnormal stria vascularis vasculature morphology 0.264107691250221 0.540714306160432 0.83739837398374 0.555555555555556 5.1 5 1 absent cochlear outer hair cells 0.264107691250221 0.540714306160432 0.83739837398374 0.555555555555556 5.1 5 1 abnormal gallbladder physiology 0.264107691250221 0.540714306160432 0.83739837398374 0.555555555555556 5.1 5 1 decreased thyroid-stimulating hormone level 0.264107691250221 0.540714306160432 0.83739837398374 0.555555555555556 5.1 5 1 liver hyperplasia 0.264107691250221 0.540714306160432 0.83739837398374 0.555555555555556 5.1 5 1 abnormal posterior eye segment morphology 0.264107691250221 0.540714306160432 0.83739837398374 0.555555555555556 5.1 5 1 abnormal intervertebral disk development 0.264107691250221 0.540714306160432 0.83739837398374 0.555555555555556 5.1 5 1 absent adrenal gland 0.264107691250221 0.540714306160432 0.83739837398374 0.555555555555556 5.1 5 1 decreased pulmonary ventilation 0.264107691250221 0.540714306160432 0.83739837398374 0.555555555555556 5.1 5 1 abnormal retinal development 0.264107691250221 0.540714306160432 0.83739837398374 0.555555555555556 5.1 5 1 abnormal liver vasculature morphology 0.264107691250221 0.540714306160432 0.83739837398374 0.555555555555556 5.1 5 1 abnormal hyoid bone lesser horn morphology 0.264107691250221 0.540714306160432 0.83739837398374 0.555555555555556 5.1 5 1 decreased transitional stage T1 B cell number 0.264107691250221 0.540714306160432 0.83739837398374 0.555555555555556 5.1 5 1 axonal spheroids 0.264107691250221 0.540714306160432 0.83739837398374 0.555555555555556 5.1 5 1 abnormal pulmonary alveolar parenchyma morphology 0.264107691250221 0.540714306160432 0.83739837398374 0.555555555555556 5.1 5 1 decreased airway resistance 0.264107691250221 0.540714306160432 0.83739837398374 0.555555555555556 5.1 5 1 abnormal oxidative phosphorylation 0.264107691250221 0.540714306160432 0.83739837398374 0.555555555555556 5.1 5 1 decreased bone trabecular spacing 0.264107691250221 0.540714306160432 0.83739837398374 0.555555555555556 5.1 5 1 symmetric azygos veins 0.264107691250221 0.540714306160432 0.83739837398374 0.555555555555556 5.1 5 1 enhanced leukocyte tethering or rolling 0.264107691250221 0.540714306160432 0.83739837398374 0.555555555555556 5.1 5 1 decreased hair follicle number 0.0395007454250623 0.160965433449397 0.832991014120667 0.552631578947368 5.1 5 1 abnormal compact bone morphology 0.0395007454250623 0.160965433449397 0.832991014120667 0.552631578947368 5.1 5 1 decreased compact bone thickness 0.00784119812014555 0.0486408486879353 0.832398980706225 0.552238805970149 5.1 5 1 internal hemorrhage 0.00784119812014555 0.0486408486879353 0.832398980706225 0.552238805970149 5.1 5 1 dermatitis 0.0131068937005559 0.0709540763441413 0.831623212783852 0.551724137931034 5.1 5 1 focal hair loss 0.0691071845161653 0.225448028175687 0.831623212783852 0.551724137931034 5.1 5 1 aphagia 0.0691071845161653 0.225448028175687 0.831623212783852 0.551724137931034 5.1 5 1 abnormal CD8-positive, alpha-beta T cell physiology 0.0691071845161653 0.225448028175687 0.831623212783852 0.551724137931034 5.1 5 1 increased urine protein level 0.00454894154679453 0.0316960562959423 0.830956848030019 0.551282051282051 5.1 5 1 decreased circulating creatinine level 0.0221143075244354 0.106093230408935 0.830562468889995 0.551020408163265 5.1 5 1 impaired ovarian folliculogenesis 0.0377973007976155 0.156051096654056 0.829024390243903 0.55 5.1 5 1 increased susceptibility to weight loss 0.0377973007976155 0.156051096654056 0.829024390243903 0.55 5.1 5 1 abnormal fibula morphology 0.125186617778281 0.353063165219358 0.829024390243903 0.55 5.1 5 1 abnormal hyoid bone morphology 0.125186617778281 0.353063165219358 0.829024390243903 0.55 5.1 5 1 abnormal heart electrocardiography waveform feature 0.125186617778281 0.353063165219358 0.829024390243903 0.55 5.1 5 1 decreased muscle cell glucose uptake 0.125186617778281 0.353063165219358 0.829024390243903 0.55 5.1 5 1 increased grip strength 0.00255818328004463 0.0202658627678695 0.828196194049853 0.549450549450549 5.1 5 1 abnormal cranial ganglia morphology 0.0658472659359114 0.215378138087547 0.826593233674272 0.548387096774194 5.1 5 1 increased lung adenoma incidence 0.0658472659359114 0.215378138087547 0.826593233674272 0.548387096774194 5.1 5 1 abnormal retinal photoreceptor layer morphology 0.0658472659359114 0.215378138087547 0.826593233674272 0.548387096774194 5.1 5 1 decreased thymus weight 0.0658472659359114 0.215378138087547 0.826593233674272 0.548387096774194 5.1 5 1 abnormal CD8-positive, alpha beta T cell morphology 0.0658472659359114 0.215378138087547 0.826593233674272 0.548387096774194 5.1 5 1 small cranium 0.0658472659359114 0.215378138087547 0.826593233674272 0.548387096774194 5.1 5 1 abnormal pancreas morphology 0.036147061133637 0.149485976009845 0.825435540069686 0.547619047619048 5.1 5 1 renal interstitial fibrosis 0.0345528347172622 0.14313101808358 0.822172949002217 0.545454545454545 5.1 5 1 abnormal photoreceptor outer segment morphology 0.0345528347172622 0.14313101808358 0.822172949002217 0.545454545454545 5.1 5 1 testis hypoplasia 0.118347815987838 0.334534309397439 0.822172949002217 0.545454545454545 5.1 5 1 abnormal lysosome physiology 0.118347815987838 0.334534309397439 0.822172949002217 0.545454545454545 5.1 5 1 abnormal vascular branching morphogenesis 0.118347815987838 0.334534309397439 0.822172949002217 0.545454545454545 5.1 5 1 parakeratosis 0.118347815987838 0.334534309397439 0.822172949002217 0.545454545454545 5.1 5 1 abnormal blood-brain barrier function 0.118347815987838 0.334534309397439 0.822172949002217 0.545454545454545 5.1 5 1 abnormal mesenteric lymph node morphology 0.118347815987838 0.334534309397439 0.822172949002217 0.545454545454545 5.1 5 1 abnormal temporal bone morphology 0.118347815987838 0.334534309397439 0.822172949002217 0.545454545454545 5.1 5 1 pulmonary vascular congestion 0.118347815987838 0.334534309397439 0.822172949002217 0.545454545454545 5.1 5 1 abnormal sphenoid bone morphology 0.24389884731835 0.5089751532755 0.822172949002217 0.545454545454545 5.1 5 1 abnormal stomach epithelium morphology 0.24389884731835 0.5089751532755 0.822172949002217 0.545454545454545 5.1 5 1 delayed hepatic development 0.24389884731835 0.5089751532755 0.822172949002217 0.545454545454545 5.1 5 1 abnormal hemoglobin 0.24389884731835 0.5089751532755 0.822172949002217 0.545454545454545 5.1 5 1 abnormal bronchiole morphology 0.24389884731835 0.5089751532755 0.822172949002217 0.545454545454545 5.1 5 1 fused joints 0.24389884731835 0.5089751532755 0.822172949002217 0.545454545454545 5.1 5 1 rectal hemorrhage 0.24389884731835 0.5089751532755 0.822172949002217 0.545454545454545 5.1 5 1 pathological neovascularization 0.24389884731835 0.5089751532755 0.822172949002217 0.545454545454545 5.1 5 1 abnormal pituitary gland development 0.24389884731835 0.5089751532755 0.822172949002217 0.545454545454545 5.1 5 1 enlarged placenta 0.24389884731835 0.5089751532755 0.822172949002217 0.545454545454545 5.1 5 1 increased glycogen level 0.24389884731835 0.5089751532755 0.822172949002217 0.545454545454545 5.1 5 1 abnormal platelet aggregation 0.24389884731835 0.5089751532755 0.822172949002217 0.545454545454545 5.1 5 1 abnormal palate development 0.24389884731835 0.5089751532755 0.822172949002217 0.545454545454545 5.1 5 1 decreased palatine bone horizontal plate size 0.24389884731835 0.5089751532755 0.822172949002217 0.545454545454545 5.1 5 1 shortened PR interval 0.24389884731835 0.5089751532755 0.822172949002217 0.545454545454545 5.1 5 1 increased pancreatic beta cell proliferation 0.24389884731835 0.5089751532755 0.822172949002217 0.545454545454545 5.1 5 1 decreased colon length 0.24389884731835 0.5089751532755 0.822172949002217 0.545454545454545 5.1 5 1 increased osteoblast cell number 0.0627133645619256 0.208715943367716 0.822172949002217 0.545454545454545 5.1 5 1 diarrhea 0.0627133645619256 0.208715943367716 0.822172949002217 0.545454545454545 5.1 5 1 increased red blood cell distribution width 0.0597091858000299 0.208715943367716 0.818257839721254 0.542857142857143 5.1 5 1 decreased ovulation rate 0.111893963780714 0.318462511332411 0.816463414634146 0.541666666666667 5.1 5 1 hypopigmentation 0.111893963780714 0.318462511332411 0.816463414634146 0.541666666666667 5.1 5 1 abnormal lung saccule morphology 0.111893963780714 0.318462511332411 0.816463414634146 0.541666666666667 5.1 5 1 increased brown adipose tissue amount 0.056835488577507 0.201168604876904 0.814765985497693 0.540540540540541 5.1 5 1 increased white adipose tissue amount 0.056835488577507 0.201168604876904 0.814765985497693 0.540540540540541 5.1 5 1 abnormal chromosome morphology 0.056835488577507 0.201168604876904 0.814765985497693 0.540540540540541 5.1 5 1 abnormal digestive system physiology 0.0301174610577323 0.132245691758357 0.813951219512195 0.54 5.1 5 1 testicular atrophy 0.0301174610577323 0.132245691758357 0.813951219512195 0.54 5.1 5 1 skin lesions 0.0163428670107863 0.086403574260002 0.813472706155633 0.53968253968254 5.1 5 1 increased circulating glucose level 0.000513636714260502 0.00543077607652045 0.812454592631033 0.539007092198582 5.1 5 1 abnormal hair growth 0.0287547117027022 0.127046794601193 0.811632270168855 0.538461538461538 5.1 5 1 abnormal female meiosis 0.0287547117027022 0.127046794601193 0.811632270168855 0.538461538461538 5.1 5 1 decreased B-1 B cell number 0.0540910226939475 0.199779389682545 0.811632270168855 0.538461538461538 5.1 5 1 thick skin 0.105812015529041 0.30184333558313 0.811632270168855 0.538461538461538 5.1 5 1 pulmonary edema 0.105812015529041 0.30184333558313 0.811632270168855 0.538461538461538 5.1 5 1 abnormal renal/urinary system morphology 0.226131340671027 0.477708458530089 0.811632270168855 0.538461538461538 5.1 5 1 increased foot pad pigmentation 0.226131340671027 0.477708458530089 0.811632270168855 0.538461538461538 5.1 5 1 abnormal digestion 0.226131340671027 0.477708458530089 0.811632270168855 0.538461538461538 5.1 5 1 increased circulating adrenocorticotropin level 0.226131340671027 0.477708458530089 0.811632270168855 0.538461538461538 5.1 5 1 anal atresia 0.226131340671027 0.477708458530089 0.811632270168855 0.538461538461538 5.1 5 1 abnormal telomere length 0.226131340671027 0.477708458530089 0.811632270168855 0.538461538461538 5.1 5 1 abnormal dopaminergic neuron morphology 0.226131340671027 0.477708458530089 0.811632270168855 0.538461538461538 5.1 5 1 abnormal GABAergic neuron morphology 0.226131340671027 0.477708458530089 0.811632270168855 0.538461538461538 5.1 5 1 decreased luteinizing hormone level 0.226131340671027 0.477708458530089 0.811632270168855 0.538461538461538 5.1 5 1 small pituitary gland 0.226131340671027 0.477708458530089 0.811632270168855 0.538461538461538 5.1 5 1 empty decidua capsularis 0.226131340671027 0.477708458530089 0.811632270168855 0.538461538461538 5.1 5 1 increased leukocyte cell number 0.00047381168508367 0.00514675356613811 0.810832632464256 0.537931034482759 5.1 5 1 decreased platelet aggregation 0.0274485183330841 0.123023764600985 0.809485094850948 0.537037037037037 5.1 5 1 abnormal response/metabolism to endogenous compounds 0.00790792163446483 0.0489327240441076 0.808804283164783 0.536585365853659 5.1 5 1 short ulna 0.0514731788147234 0.195480201987213 0.808804283164783 0.536585365853659 5.1 5 1 abnormal epidermal layer morphology 0.0142970972755324 0.0770618190095056 0.808271474019088 0.536231884057971 5.1 5 1 abnormal coat appearance 0.0142970972755324 0.0770618190095056 0.808271474019088 0.536231884057971 5.1 5 1 increased lymphocyte cell number 0.0142970972755324 0.0770618190095056 0.808271474019088 0.536231884057971 5.1 5 1 abnormal stria vascularis morphology 0.100084678438142 0.285997286174473 0.807491289198606 0.535714285714286 5.1 5 1 reddish skin 0.100084678438142 0.285997286174473 0.807491289198606 0.535714285714286 5.1 5 1 abnormal retinal inner nuclear layer morphology 0.100084678438142 0.285997286174473 0.807491289198606 0.535714285714286 5.1 5 1 atelectasis 0.0136691952932145 0.0739176593301547 0.806733081415321 0.535211267605634 5.1 5 1 short femur 0.00693475978298447 0.0442313204107022 0.805044345898004 0.534090909090909 5.1 5 1 increased T cell number 0.00693475978298447 0.0442313204107022 0.805044345898004 0.534090909090909 5.1 5 1 arrested T cell differentiation 0.094692846287413 0.281411926734436 0.80390243902439 0.533333333333333 5.1 5 1 abnormal fat pad morphology 0.094692846287413 0.281411926734436 0.80390243902439 0.533333333333333 5.1 5 1 decreased chondrocyte number 0.210307452869277 0.447893654976306 0.80390243902439 0.533333333333333 5.1 5 1 abnormal lymph node B cell domain morphology 0.210307452869277 0.447893654976306 0.80390243902439 0.533333333333333 5.1 5 1 increased alcohol consumption 0.210307452869277 0.447893654976306 0.80390243902439 0.533333333333333 5.1 5 1 greasy coat 0.210307452869277 0.447893654976306 0.80390243902439 0.533333333333333 5.1 5 1 abnormal zygomatic bone morphology 0.210307452869277 0.447893654976306 0.80390243902439 0.533333333333333 5.1 5 1 abnormal energy homeostasis 0.210307452869277 0.447893654976306 0.80390243902439 0.533333333333333 5.1 5 1 absent chorion 0.210307452869277 0.447893654976306 0.80390243902439 0.533333333333333 5.1 5 1 ostium primum atrial septal defect 0.210307452869277 0.447893654976306 0.80390243902439 0.533333333333333 5.1 5 1 bicuspid aortic valve 0.210307452869277 0.447893654976306 0.80390243902439 0.533333333333333 5.1 5 1 abnormal microglial cell activation 0.210307452869277 0.447893654976306 0.80390243902439 0.533333333333333 5.1 5 1 herniated liver 0.210307452869277 0.447893654976306 0.80390243902439 0.533333333333333 5.1 5 1 increased respiratory quotient 0.0443415702671019 0.175636394967223 0.80176440062273 0.531914893617021 5.1 5 1 abnormal response to infection 0.0114077901563222 0.065535515043537 0.801358443964187 0.531645569620253 5.1 5 1 polydipsia 0.0896169614659142 0.274873232609694 0.800762195121951 0.53125 5.1 5 1 neonatal lethality 0.0896169614659142 0.274873232609694 0.800762195121951 0.53125 5.1 5 1 increased spleen weight 0.00299388126472532 0.0228094323001661 0.800345348586229 0.530973451327434 5.1 5 1 increased fluid intake 0.042190346175238 0.16778335109657 0.799800895968144 0.530612244897959 5.1 5 1 impaired hematopoiesis 0.0401443401185409 0.160965433449397 0.797991391678623 0.529411764705882 5.1 5 1 abnormal cervical vertebrae morphology 0.0401443401185409 0.160965433449397 0.797991391678623 0.529411764705882 5.1 5 1 short maxilla 0.0848377745524079 0.266314807941775 0.797991391678623 0.529411764705882 5.1 5 1 thin skin 0.0848377745524079 0.266314807941775 0.797991391678623 0.529411764705882 5.1 5 1 decreased regulatory T cell number 0.0848377745524079 0.266314807941775 0.797991391678623 0.529411764705882 5.1 5 1 abnormal skin physiology 0.0848377745524079 0.266314807941775 0.797991391678623 0.529411764705882 5.1 5 1 abnormal urinary bladder morphology 0.196079131141394 0.421197615469964 0.797991391678623 0.529411764705882 5.1 5 1 abnormal testis development 0.196079131141394 0.421197615469964 0.797991391678623 0.529411764705882 5.1 5 1 increased regulatory T cell number 0.196079131141394 0.421197615469964 0.797991391678623 0.529411764705882 5.1 5 1 abnormal melanosome morphology 0.196079131141394 0.421197615469964 0.797991391678623 0.529411764705882 5.1 5 1 pancytopenia 0.196079131141394 0.421197615469964 0.797991391678623 0.529411764705882 5.1 5 1 increased circulating magnesium level 0.196079131141394 0.421197615469964 0.797991391678623 0.529411764705882 5.1 5 1 common atrium 0.196079131141394 0.421197615469964 0.797991391678623 0.529411764705882 5.1 5 1 delayed heart development 0.196079131141394 0.421197615469964 0.797991391678623 0.529411764705882 5.1 5 1 abnormal cell cytoskeleton morphology 0.196079131141394 0.421197615469964 0.797991391678623 0.529411764705882 5.1 5 1 abnormal enzyme/coenzyme activity 0.000655856684004412 0.00656516499581881 0.796861892185801 0.528662420382166 5.1 5 1 short radius 0.0803367574617951 0.259698095108792 0.795528455284553 0.527777777777778 5.1 5 1 increased granulocyte number 0.0171536846922053 0.0893608181609645 0.794396835860251 0.527027027027027 5.1 5 1 alopecia 0.00791788754771463 0.0489335286333916 0.793324775353017 0.526315789473684 5.1 5 1 abnormal axial skeleton morphology 0.0163624618693583 0.0864153373673645 0.793324775353017 0.526315789473684 5.1 5 1 decreased threshold for auditory brainstem response 0.0760963143024451 0.246792153621033 0.793324775353017 0.526315789473684 5.1 5 1 abnormal triglyceride level 0.183190787357987 0.395733463788964 0.793324775353017 0.526315789473684 5.1 5 1 small superior vagus ganglion 0.183190787357987 0.395733463788964 0.793324775353017 0.526315789473684 5.1 5 1 flaky skin 0.183190787357987 0.395733463788964 0.793324775353017 0.526315789473684 5.1 5 1 thin dermal layer 0.183190787357987 0.395733463788964 0.793324775353017 0.526315789473684 5.1 5 1 decreased grooming behavior 0.183190787357987 0.395733463788964 0.793324775353017 0.526315789473684 5.1 5 1 abnormal photoreceptor inner segment morphology 0.183190787357987 0.395733463788964 0.793324775353017 0.526315789473684 5.1 5 1 increased left ventricle weight 0.183190787357987 0.395733463788964 0.793324775353017 0.526315789473684 5.1 5 1 absent amnion 0.183190787357987 0.395733463788964 0.793324775353017 0.526315789473684 5.1 5 1 abnormal thoracic vertebrae morphology 0.0329196784518528 0.14096250655862 0.791980157089706 0.525423728813559 5.1 5 1 liver inflammation 0.00339806959838462 0.0255368523443557 0.791341463414634 0.525 5.1 5 1 increased keratinocyte proliferation 0.171447611921605 0.385697839433079 0.789547038327526 0.523809523809524 5.1 5 1 complete atrioventricular septal defect 0.171447611921605 0.385697839433079 0.789547038327526 0.523809523809524 5.1 5 1 abnormal dendritic cell physiology 0.00601268943347906 0.0389493879317166 0.78887622521085 0.523364485981308 5.1 5 1 osteoporosis 0.0647779208803324 0.212719575168088 0.787915742793792 0.522727272727273 5.1 5 1 abnormal amino acid level 0.0647779208803324 0.212719575168088 0.787915742793792 0.522727272727273 5.1 5 1 abnormal femur morphology 0.0270217174357902 0.121220057928815 0.787404441208591 0.522388059701492 5.1 5 1 abnormal lymphocyte physiology 0.0614243985300041 0.208715943367716 0.786426299045599 0.521739130434783 5.1 5 1 abnormal postnatal growth 0.160696712290628 0.385697839433079 0.786426299045599 0.521739130434783 5.1 5 1 decreased epididymis weight 0.160696712290628 0.385697839433079 0.786426299045599 0.521739130434783 5.1 5 1 abnormal palatal shelf fusion at midline 0.160696712290628 0.385697839433079 0.786426299045599 0.521739130434783 5.1 5 1 abnormal intestinal epithelium morphology 0.058258761602998 0.204542935056398 0.785060975609756 0.520833333333333 5.1 5 1 abnormal cardiovascular system morphology 0.058258761602998 0.204542935056398 0.785060975609756 0.520833333333333 5.1 5 1 kidney inflammation 0.0552693050525357 0.201168604876904 0.783804878048781 0.52 5.1 5 1 abnormal keratinocyte physiology 0.150815235424196 0.385697839433079 0.783804878048781 0.52 5.1 5 1 decreased placenta weight 0.150815235424196 0.385697839433079 0.783804878048781 0.52 5.1 5 1 decreased acute inflammation 0.150815235424196 0.385697839433079 0.783804878048781 0.52 5.1 5 1 decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 0.150815235424196 0.385697839433079 0.783804878048781 0.52 5.1 5 1 decreased B cell proliferation 0.0201390906624578 0.0996561859334128 0.782278481012658 0.518987341772152 5.1 5 1 abnormal small intestine morphology 0.049776129324172 0.189614275182049 0.781571815718157 0.518518518518518 5.1 5 1 abnormal trigeminal ganglion morphology 0.141702541419819 0.385697839433079 0.781571815718157 0.518518518518518 5.1 5 1 abnormal skin appearance 0.141702541419819 0.385697839433079 0.781571815718157 0.518518518518518 5.1 5 1 abnormal bone trabecula morphology 0.141702541419819 0.385697839433079 0.781571815718157 0.518518518518518 5.1 5 1 decreased granulocyte number 0.133274850497403 0.37145231441153 0.779646761984861 0.517241379310345 5.1 5 1 abnormal spinal nerve morphology 0.133274850497403 0.37145231441153 0.779646761984861 0.517241379310345 5.1 5 1 decreased retinal photoreceptor cell number 0.133274850497403 0.37145231441153 0.779646761984861 0.517241379310345 5.1 5 1 enlarged epididymis 0.133274850497403 0.37145231441153 0.779646761984861 0.517241379310345 5.1 5 1 polychromatophilia 0.133274850497403 0.37145231441153 0.779646761984861 0.517241379310345 5.1 5 1 increased retinal apoptosis 0.133274850497403 0.37145231441153 0.779646761984861 0.517241379310345 5.1 5 1 absent mature ovarian follicles 0.125461465329015 0.353637841366486 0.777970102281668 0.516129032258065 5.1 5 1 abnormal aorta morphology 0.118202033176402 0.334534309397439 0.77649667405765 0.515151515151515 5.1 5 1 enlarged pericardium 0.118202033176402 0.334534309397439 0.77649667405765 0.515151515151515 5.1 5 1 decreased systemic arterial blood pressure 0.118202033176402 0.334534309397439 0.77649667405765 0.515151515151515 5.1 5 1 dilated heart atrium 0.118202033176402 0.334534309397439 0.77649667405765 0.515151515151515 5.1 5 1 abnormal intestinal goblet cell morphology 0.111444515584337 0.317728633256204 0.775191637630662 0.514285714285714 5.1 5 1 abnormal renal glomerulus morphology 0.0097637935182682 0.0583131725730904 0.774401432087715 0.513761467889908 5.1 5 1 decreased circulating chloride level 0.10514365239521 0.30028109682329 0.774027686222808 0.513513513513513 5.1 5 1 increased B cell number 0.0080682408806598 0.0496550963582622 0.772983114446529 0.512820512820513 5.1 5 1 acanthosis 0.099259779153496 0.284129690039495 0.772983114446529 0.512820512820513 5.1 5 1 abnormal circulating hormone level 0.099259779153496 0.284129690039495 0.772983114446529 0.512820512820513 5.1 5 1 decreased trabecular bone volume 0.099259779153496 0.284129690039495 0.772983114446529 0.512820512820513 5.1 5 1 abnormal trabecular bone morphology 0.00769355106040723 0.0481451780195295 0.772658331625333 0.512605042016807 5.1 5 1 abnormal male reproductive system morphology 0.0886069660407851 0.272615742766176 0.771185479296653 0.511627906976744 5.1 5 1 impaired macrophage phagocytosis 0.0886069660407851 0.272615742766176 0.771185479296653 0.511627906976744 5.1 5 1 altered response to myocardial infarction 0.0837792633849009 0.266314807941775 0.770406504065041 0.511111111111111 5.1 5 1 albuminuria 0.0837792633849009 0.266314807941775 0.770406504065041 0.511111111111111 5.1 5 1 decreased double-positive T cell number 0.0156544581281364 0.0829402866746313 0.768731707317073 0.51 5.1 5 1 increased lung adenocarcinoma incidence 0.0709992685838905 0.231468781916681 0.768436154949785 0.509803921568627 5.1 5 1 abnormal T-helper 2 physiology 0.0637003120475062 0.20945740412184 0.767361419068736 0.509090909090909 5.1 5 1 decreased T cell proliferation 0.00494513569963084 0.0336927055754571 0.763843111404087 0.506756756756757 5.1 5 1 polyuria 0.0357740940821137 0.148066653958832 0.763446309787773 0.506493506493506 5.1 5 1 small ovary 0.0250919322195737 0.113991163389814 0.761940498525864 0.505494505494505 5.1 5 1 abnormal malleus morphology 0.209499460800542 0.447893654976306 0.753658536585366 0.5 5.1 5 1 abnormal digestive system morphology 0.209499460800542 0.447893654976306 0.753658536585366 0.5 5.1 5 1 abnormal foregut morphology 0.209499460800542 0.447893654976306 0.753658536585366 0.5 5.1 5 1 curly vibrissae 0.209499460800542 0.447893654976306 0.753658536585366 0.5 5.1 5 1 blindness 0.209499460800542 0.447893654976306 0.753658536585366 0.5 5.1 5 1 small lymph nodes 0.209499460800542 0.447893654976306 0.753658536585366 0.5 5.1 5 1 prolonged QT interval 0.209499460800542 0.447893654976306 0.753658536585366 0.5 5.1 5 1 abnormal truncus arteriosus septation 0.209499460800542 0.447893654976306 0.753658536585366 0.5 5.1 5 1 abnormal pericardium morphology 0.241194956937693 0.50716183886941 0.753658536585366 0.5 5.1 5 1 waved hair 0.241194956937693 0.50716183886941 0.753658536585366 0.5 5.1 5 1 increased urine glucose level 0.241194956937693 0.50716183886941 0.753658536585366 0.5 5.1 5 1 abnormal hair texture 0.241194956937693 0.50716183886941 0.753658536585366 0.5 5.1 5 1 abnormal male reproductive system physiology 0.241194956937693 0.50716183886941 0.753658536585366 0.5 5.1 5 1 abnormal incus morphology 0.241194956937693 0.50716183886941 0.753658536585366 0.5 5.1 5 1 decreased circulating VLDL cholesterol level 0.241194956937693 0.50716183886941 0.753658536585366 0.5 5.1 5 1 abnormal auchene hair morphology 0.363956574278411 0.583281218863301 0.753658536585366 0.5 5.1 5 1 absent maxillary shelf 0.363956574278411 0.583281218863301 0.753658536585366 0.5 5.1 5 1 abnormal esophagus morphology 0.331680270019984 0.583281218863301 0.753658536585366 0.5 5.1 5 1 kidney hemorrhage 0.363956574278411 0.583281218863301 0.753658536585366 0.5 5.1 5 1 amyloidosis 0.331680270019984 0.583281218863301 0.753658536585366 0.5 5.1 5 1 jaundice 0.363956574278411 0.583281218863301 0.753658536585366 0.5 5.1 5 1 small petrosal ganglion 0.363956574278411 0.583281218863301 0.753658536585366 0.5 5.1 5 1 abnormal prostate gland epithelium morphology 0.363956574278411 0.583281218863301 0.753658536585366 0.5 5.1 5 1 abnormal immune cell physiology 0.363956574278411 0.583281218863301 0.753658536585366 0.5 5.1 5 1 ear inflammation 0.331680270019984 0.583281218863301 0.753658536585366 0.5 5.1 5 1 rhinitis 0.363956574278411 0.583281218863301 0.753658536585366 0.5 5.1 5 1 altered tumor susceptibility 0.331680270019984 0.583281218863301 0.753658536585366 0.5 5.1 5 1 abnormal respiratory mechanics 0.363956574278411 0.583281218863301 0.753658536585366 0.5 5.1 5 1 abnormal neuron specification 0.363956574278411 0.583281218863301 0.753658536585366 0.5 5.1 5 1 small thyroid gland 0.331680270019984 0.583281218863301 0.753658536585366 0.5 5.1 5 1 primary sex reversal 0.363956574278411 0.583281218863301 0.753658536585366 0.5 5.1 5 1 abnormal alisphenoid bone morphology 0.331680270019984 0.583281218863301 0.753658536585366 0.5 5.1 5 1 abnormal hypaxial muscle morphology 0.363956574278411 0.583281218863301 0.753658536585366 0.5 5.1 5 1 impaired sperm capacitation 0.331680270019984 0.583281218863301 0.753658536585366 0.5 5.1 5 1 abnormal glial cell physiology 0.363956574278411 0.583281218863301 0.753658536585366 0.5 5.1 5 1 absent CD4-positive, alpha beta T cells 0.363956574278411 0.583281218863301 0.753658536585366 0.5 5.1 5 1 delayed somite formation 0.331680270019984 0.583281218863301 0.753658536585366 0.5 5.1 5 1 abnormal hindlimb zeugopod morphology 0.363956574278411 0.583281218863301 0.753658536585366 0.5 5.1 5 1 increased defecation amount 0.363956574278411 0.583281218863301 0.753658536585366 0.5 5.1 5 1 abnormal gas homeostasis 0.363956574278411 0.583281218863301 0.753658536585366 0.5 5.1 5 1 abnormal placental transport 0.363956574278411 0.583281218863301 0.753658536585366 0.5 5.1 5 1 pale placenta 0.331680270019984 0.583281218863301 0.753658536585366 0.5 5.1 5 1 small parietal bone 0.331680270019984 0.583281218863301 0.753658536585366 0.5 5.1 5 1 abnormal fatty acid level 0.331680270019984 0.583281218863301 0.753658536585366 0.5 5.1 5 1 ascites 0.363956574278411 0.583281218863301 0.753658536585366 0.5 5.1 5 1 increased platelet aggregation 0.363956574278411 0.583281218863301 0.753658536585366 0.5 5.1 5 1 crystalluria 0.363956574278411 0.583281218863301 0.753658536585366 0.5 5.1 5 1 abnormal aorta elastic tissue morphology 0.331680270019984 0.583281218863301 0.753658536585366 0.5 5.1 5 1 increased skeletal muscle glycogen level 0.331680270019984 0.583281218863301 0.753658536585366 0.5 5.1 5 1 abnormal heart and great artery attachment 0.363956574278411 0.583281218863301 0.753658536585366 0.5 5.1 5 1 common ventricle 0.363956574278411 0.583281218863301 0.753658536585366 0.5 5.1 5 1 abnormal left subclavian artery morphology 0.363956574278411 0.583281218863301 0.753658536585366 0.5 5.1 5 1 thick aortic valve 0.363956574278411 0.583281218863301 0.753658536585366 0.5 5.1 5 1 abnormal pulmonary interalveolar septum morphology 0.363956574278411 0.583281218863301 0.753658536585366 0.5 5.1 5 1 abnormal colon goblet cell morphology 0.331680270019984 0.583281218863301 0.753658536585366 0.5 5.1 5 1 increased fatty acid oxidation 0.363956574278411 0.583281218863301 0.753658536585366 0.5 5.1 5 1 glomerulosclerosis 0.0758673374681835 0.246531681191517 0.753658536585366 0.5 5.1 5 1 abnormal cell adhesion 0.0847025952087397 0.266314807941775 0.753658536585366 0.5 5.1 5 1 abnormal osteoblast physiology 0.0847025952087397 0.266314807941775 0.753658536585366 0.5 5.1 5 1 increased metastatic potential 0.171856854707393 0.385697839433079 0.753658536585366 0.5 5.1 5 1 emphysema 0.171856854707393 0.385697839433079 0.753658536585366 0.5 5.1 5 1 abnormal pain threshold 0.171856854707393 0.385697839433079 0.753658536585366 0.5 5.1 5 1 increased fatty acid level 0.161305969192114 0.385697839433079 0.753658536585366 0.5 5.1 5 1 abnormal basisphenoid bone morphology 0.224547407855373 0.476588461638431 0.753658536585366 0.5 5.1 5 1 abnormal oogenesis 0.224547407855373 0.476588461638431 0.753658536585366 0.5 5.1 5 1 abnormal circulating lipid level 0.224547407855373 0.476588461638431 0.753658536585366 0.5 5.1 5 1 rough coat 0.224547407855373 0.476588461638431 0.753658536585366 0.5 5.1 5 1 impaired humoral immune response 0.224547407855373 0.476588461638431 0.753658536585366 0.5 5.1 5 1 absent mandible 0.280595030542505 0.572330213078261 0.753658536585366 0.5 5.1 5 1 abnormal extraembryonic endoderm formation 0.280595030542505 0.572330213078261 0.753658536585366 0.5 5.1 5 1 abnormal molar crown morphology 0.280595030542505 0.572330213078261 0.753658536585366 0.5 5.1 5 1 abnormal level of surface class II molecules 0.280595030542505 0.572330213078261 0.753658536585366 0.5 5.1 5 1 decreased circulating growth hormone level 0.280595030542505 0.572330213078261 0.753658536585366 0.5 5.1 5 1 decreased circulating triiodothyronine level 0.280595030542505 0.572330213078261 0.753658536585366 0.5 5.1 5 1 abnormal urinary bladder physiology 0.280595030542505 0.572330213078261 0.753658536585366 0.5 5.1 5 1 dilated respiratory conducting tubes 0.280595030542505 0.572330213078261 0.753658536585366 0.5 5.1 5 1 abnormal heart left ventricle morphology 0.05213709870983 0.197565490697037 0.753658536585366 0.5 5.1 5 1 abnormal skin condition 0.089553398360134 0.274873232609694 0.753658536585366 0.5 5.1 5 1 decreased body temperature 0.089553398360134 0.274873232609694 0.753658536585366 0.5 5.1 5 1 abnormal tectorial membrane morphology 0.195818455319351 0.421197615469964 0.753658536585366 0.5 5.1 5 1 abnormal radius morphology 0.259743493658904 0.539776057206788 0.753658536585366 0.5 5.1 5 1 thick dermal layer 0.259743493658904 0.539776057206788 0.753658536585366 0.5 5.1 5 1 abnormal white adipose tissue morphology 0.259743493658904 0.539776057206788 0.753658536585366 0.5 5.1 5 1 acidosis 0.259743493658904 0.539776057206788 0.753658536585366 0.5 5.1 5 1 increased susceptibility to autoimmune disorder 0.259743493658904 0.539776057206788 0.753658536585366 0.5 5.1 5 1 jerky movement 0.259743493658904 0.539776057206788 0.753658536585366 0.5 5.1 5 1 abnormal vasoconstriction 0.304305588246398 0.583281218863301 0.753658536585366 0.5 5.1 5 1 absent atrioventricular cushions 0.304305588246398 0.583281218863301 0.753658536585366 0.5 5.1 5 1 absent visceral yolk sac blood islands 0.304305588246398 0.583281218863301 0.753658536585366 0.5 5.1 5 1 abnormal fluid regulation 0.304305588246398 0.583281218863301 0.753658536585366 0.5 5.1 5 1 vascular smooth muscle hypoplasia 0.304305588246398 0.583281218863301 0.753658536585366 0.5 5.1 5 1 abnormal decidualization 0.304305588246398 0.583281218863301 0.753658536585366 0.5 5.1 5 1 abnormal pancreas development 0.304305588246398 0.583281218863301 0.753658536585366 0.5 5.1 5 1 split sternum 0.304305588246398 0.583281218863301 0.753658536585366 0.5 5.1 5 1 abnormal positive T cell selection 0.304305588246398 0.583281218863301 0.753658536585366 0.5 5.1 5 1 premature hair loss 0.304305588246398 0.583281218863301 0.753658536585366 0.5 5.1 5 1 increased pulmonary respiratory rate 0.304305588246398 0.583281218863301 0.753658536585366 0.5 5.1 5 1 increased stomach tumor incidence 0.304305588246398 0.583281218863301 0.753658536585366 0.5 5.1 5 1 increased lung compliance 0.304305588246398 0.583281218863301 0.753658536585366 0.5 5.1 5 1 increased T cell proliferation 0.0268667884019717 0.120742793405428 0.746614998860269 0.495327102803738 5.1 5 1 abnormal T cell differentiation 0.0312292430602622 0.136069004100851 0.7461965708766 0.495049504950495 5.1 5 1 spleen hyperplasia 0.0609723439554304 0.208715943367716 0.743609756097561 0.493333333333333 5.1 5 1 abnormal CD4-positive, alpha-beta T cell physiology 0.0677987936423181 0.221615636248707 0.743043627619375 0.492957746478873 5.1 5 1 maternal effect 0.0754731381994844 0.245411021269565 0.742409901710957 0.492537313432836 5.1 5 1 increased double-negative T cell number 0.0888535920033615 0.273205574917629 0.741303478608556 0.491803278688525 5.1 5 1 abnormal colon morphology 0.0938879989347602 0.281411926734436 0.740884663083919 0.491525423728814 5.1 5 1 abnormal blood homeostasis 0.0281234076715485 0.125708852799599 0.740436456996149 0.491228070175439 5.1 5 1 decreased susceptibility to induced arthritis 0.0992465451932363 0.284129690039495 0.740436456996149 0.491228070175439 5.1 5 1 increased macrophage cell number 0.0992465451932363 0.284129690039495 0.740436456996149 0.491228070175439 5.1 5 1 increased neutrophil cell number 0.0162786618002827 0.0861556834642624 0.738065601345669 0.489655172413793 5.1 5 1 decreased osteoclast cell number 0.139846813460342 0.385697839433079 0.736910569105691 0.488888888888889 5.1 5 1 increased liver weight 0.0542818220840226 0.200335359694371 0.736529933481153 0.488636363636364 5.1 5 1 abnormal intestinal mucosa morphology 0.148370966268877 0.385697839433079 0.736131593874078 0.488372093023256 5.1 5 1 abnormal blood circulation 0.148370966268877 0.385697839433079 0.736131593874078 0.488372093023256 5.1 5 1 arrested B cell differentiation 0.157526144876108 0.385697839433079 0.735276621058894 0.48780487804878 5.1 5 1 abnormal lens fiber morphology 0.16737564125573 0.385697839433079 0.734333958724203 0.487179487179487 5.1 5 1 increased vascular permeability 0.16737564125573 0.385697839433079 0.734333958724203 0.487179487179487 5.1 5 1 increased insulin secretion 0.177992020212671 0.385843268217009 0.733289386947924 0.486486486486487 5.1 5 1 abnormal tail morphology 0.0971198436102464 0.281411926734436 0.730820399113082 0.484848484848485 5.1 5 1 absent vibrissae 0.201874379559843 0.433459231035916 0.730820399113082 0.484848484848485 5.1 5 1 increased inflammatory response 0.0560917020002217 0.201168604876904 0.729858793324775 0.484210526315789 5.1 5 1 abnormal nose morphology 0.215352532249624 0.458245871660342 0.729346970889064 0.483870967741935 5.1 5 1 decreased neuronal precursor cell number 0.215352532249624 0.458245871660342 0.729346970889064 0.483870967741935 5.1 5 1 increased sensitivity to induced morbidity/mortality 0.0117461742037315 0.0671414961383204 0.729082714740191 0.483695652173913 5.1 5 1 decreased bone strength 0.230029588045318 0.485531268784667 0.72767031118587 0.482758620689655 5.1 5 1 cryptorchism 0.246068946797487 0.513288473927671 0.725745257452574 0.481481481481481 5.1 5 1 diaphragmatic hernia 0.263669514994092 0.540714306160432 0.723512195121951 0.48 5.1 5 1 abnormal cranial nerve morphology 0.283077212123056 0.572620638868235 0.720890774125133 0.478260869565217 5.1 5 1 bidirectional circling 0.283077212123056 0.572620638868235 0.720890774125133 0.478260869565217 5.1 5 1 hypotension 0.283077212123056 0.572620638868235 0.720890774125133 0.478260869565217 5.1 5 1 pancreas inflammation 0.283077212123056 0.572620638868235 0.720890774125133 0.478260869565217 5.1 5 1 increased susceptibility to fungal infection 0.283077212123056 0.572620638868235 0.720890774125133 0.478260869565217 5.1 5 1 abnormal hepatocyte physiology 0.283077212123056 0.572620638868235 0.720890774125133 0.478260869565217 5.1 5 1 skin edema 0.192382734408895 0.415229546066921 0.717770034843206 0.476190476190476 5.1 5 1 abnormal vibrissa morphology 0.192382734408895 0.415229546066921 0.717770034843206 0.476190476190476 5.1 5 1 abnormal salivary gland morphology 0.304601634225046 0.583281218863301 0.717770034843206 0.476190476190476 5.1 5 1 increased vasoconstriction 0.304601634225046 0.583281218863301 0.717770034843206 0.476190476190476 5.1 5 1 dry skin 0.304601634225046 0.583281218863301 0.717770034843206 0.476190476190476 5.1 5 1 abnormal stapes morphology 0.304601634225046 0.583281218863301 0.717770034843206 0.476190476190476 5.1 5 1 increased B cell proliferation 0.145616039837223 0.385697839433079 0.715336916081025 0.474576271186441 5.1 5 1 irregular coat pigmentation 0.32864092932973 0.583281218863301 0.713992297817715 0.473684210526316 5.1 5 1 decreased germ cell number 0.32864092932973 0.583281218863301 0.713992297817715 0.473684210526316 5.1 5 1 eyelids fail to open 0.32864092932973 0.583281218863301 0.713992297817715 0.473684210526316 5.1 5 1 decreased susceptibility to weight gain 0.32864092932973 0.583281218863301 0.713992297817715 0.473684210526316 5.1 5 1 thin interventricular septum 0.32864092932973 0.583281218863301 0.713992297817715 0.473684210526316 5.1 5 1 abnormal facial morphology 0.153974979824262 0.385697839433079 0.713992297817715 0.473684210526316 5.1 5 1 abnormal circulating amino acid level 0.153974979824262 0.385697839433079 0.713992297817715 0.473684210526316 5.1 5 1 impaired wound healing 0.231428328586495 0.488069493309799 0.711788617886179 0.472222222222222 5.1 5 1 narrow eye opening 0.231428328586495 0.488069493309799 0.711788617886179 0.472222222222222 5.1 5 1 thick epidermis 0.131801357138456 0.370299872908274 0.710592334494774 0.471428571428571 5.1 5 1 abnormal endoderm development 0.246592679790461 0.514165373829649 0.709325681492109 0.470588235294118 5.1 5 1 abnormal duodenum morphology 0.355720274454605 0.583281218863301 0.709325681492109 0.470588235294118 5.1 5 1 abnormal circulating chemokine level 0.355720274454605 0.583281218863301 0.709325681492109 0.470588235294118 5.1 5 1 abnormal respiratory system physiology 0.193352306951631 0.417141251988016 0.707516177202589 0.469387755102041 5.1 5 1 abnormal vertebral body morphology 0.263040676123898 0.540714306160432 0.70655487804878 0.46875 5.1 5 1 abnormal cytokine secretion 0.0489988528452375 0.187061305256002 0.704719670573329 0.467532467532468 5.1 5 1 salivary gland inflammation 0.280930729716003 0.572330213078261 0.703414634146341 0.466666666666667 5.1 5 1 abnormal estrous cycle 0.280930729716003 0.572330213078261 0.703414634146341 0.466666666666667 5.1 5 1 abnormal spleen marginal zone morphology 0.280930729716003 0.572330213078261 0.703414634146341 0.466666666666667 5.1 5 1 placental labyrinth hypoplasia 0.386553956701379 0.583281218863301 0.703414634146341 0.466666666666667 5.1 5 1 increased airway responsiveness 0.386553956701379 0.583281218863301 0.703414634146341 0.466666666666667 5.1 5 1 altered righting response 0.386553956701379 0.583281218863301 0.703414634146341 0.466666666666667 5.1 5 1 abnormal pericyte morphology 0.386553956701379 0.583281218863301 0.703414634146341 0.466666666666667 5.1 5 1 abnormal dendritic cell morphology 0.386553956701379 0.583281218863301 0.703414634146341 0.466666666666667 5.1 5 1 abnormal aorta wall morphology 0.386553956701379 0.583281218863301 0.703414634146341 0.466666666666667 5.1 5 1 liver vascular congestion 0.386553956701379 0.583281218863301 0.703414634146341 0.466666666666667 5.1 5 1 abnormal circulating cholesterol level 0.300451016874011 0.583281218863301 0.699825783972125 0.464285714285714 5.1 5 1 abnormal leukocyte migration 0.216009770427003 0.459447887077528 0.695684803001876 0.461538461538462 5.1 5 1 short hair 0.422150780890518 0.608577263091953 0.695684803001876 0.461538461538462 5.1 5 1 increased pituitary adenoma incidence 0.422150780890518 0.608577263091953 0.695684803001876 0.461538461538462 5.1 5 1 abnormal pulmonary alveolus epithelial cell morphology 0.422150780890518 0.608577263091953 0.695684803001876 0.461538461538462 5.1 5 1 abnormal lung interstitium morphology 0.422150780890518 0.608577263091953 0.695684803001876 0.461538461538462 5.1 5 1 abnormal soleus morphology 0.422150780890518 0.608577263091953 0.695684803001876 0.461538461538462 5.1 5 1 decreased alcohol consumption 0.422150780890518 0.608577263091953 0.695684803001876 0.461538461538462 5.1 5 1 increased circulating thyroid-stimulating hormone level 0.422150780890518 0.608577263091953 0.695684803001876 0.461538461538462 5.1 5 1 abnormal exocrine pancreas morphology 0.422150780890518 0.608577263091953 0.695684803001876 0.461538461538462 5.1 5 1 abnormal vertebral arch development 0.422150780890518 0.608577263091953 0.695684803001876 0.461538461538462 5.1 5 1 abnormal circulating protein level 0.228630312938171 0.482782600537947 0.693365853658537 0.46 5.1 5 1 abnormal T cell activation 0.171509929203743 0.385697839433079 0.692551087673039 0.459459459459459 5.1 5 1 abnormal urine homeostasis 0.138540502225535 0.385697839433079 0.690853658536585 0.458333333333333 5.1 5 1 abnormal lymph node morphology 0.242100662008709 0.508851201306856 0.690853658536585 0.458333333333333 5.1 5 1 abnormal adrenal gland morphology 0.345335309395952 0.583281218863301 0.690853658536585 0.458333333333333 5.1 5 1 abnormal osteoblast morphology 0.345335309395952 0.583281218863301 0.690853658536585 0.458333333333333 5.1 5 1 decreased macrophage cell number 0.271881082559647 0.556399994131733 0.685144124168514 0.454545454545455 5.1 5 1 abnormal facial nerve morphology 0.371313489533108 0.583281218863301 0.685144124168514 0.454545454545455 5.1 5 1 abnormal female reproductive system physiology 0.371313489533108 0.583281218863301 0.685144124168514 0.454545454545455 5.1 5 1 abnormal retinal layer morphology 0.371313489533108 0.583281218863301 0.685144124168514 0.454545454545455 5.1 5 1 decreased susceptibility to viral infection induced morbidity/mortality 0.371313489533108 0.583281218863301 0.685144124168514 0.454545454545455 5.1 5 1 abnormal thrombopoiesis 0.464004680078462 0.653759072044845 0.685144124168514 0.454545454545455 5.1 5 1 decreased atrioventricular cushion size 0.464004680078462 0.653759072044845 0.685144124168514 0.454545454545455 5.1 5 1 increased mast cell number 0.464004680078462 0.653759072044845 0.685144124168514 0.454545454545455 5.1 5 1 impaired myelopoiesis 0.464004680078462 0.653759072044845 0.685144124168514 0.454545454545455 5.1 5 1 abnormal larynx morphology 0.464004680078462 0.653759072044845 0.685144124168514 0.454545454545455 5.1 5 1 variable body spotting 0.464004680078462 0.653759072044845 0.685144124168514 0.454545454545455 5.1 5 1 allodynia 0.464004680078462 0.653759072044845 0.685144124168514 0.454545454545455 5.1 5 1 dilated renal glomerular capsule 0.464004680078462 0.653759072044845 0.685144124168514 0.454545454545455 5.1 5 1 abnormal superovulation 0.464004680078462 0.653759072044845 0.685144124168514 0.454545454545455 5.1 5 1 abnormal aorta smooth muscle morphology 0.464004680078462 0.653759072044845 0.685144124168514 0.454545454545455 5.1 5 1 aberrant origin of the right subclavian artery 0.464004680078462 0.653759072044845 0.685144124168514 0.454545454545455 5.1 5 1 abnormal extraembryonic ectoderm morphology 0.464004680078462 0.653759072044845 0.685144124168514 0.454545454545455 5.1 5 1 increased subcutaneous adipose tissue amount 0.464004680078462 0.653759072044845 0.685144124168514 0.454545454545455 5.1 5 1 chylous ascites 0.464004680078462 0.653759072044845 0.685144124168514 0.454545454545455 5.1 5 1 hypolactation 0.464004680078462 0.653759072044845 0.685144124168514 0.454545454545455 5.1 5 1 decreased IgM level 0.15875864195934 0.385697839433079 0.68373145587126 0.45360824742268 5.1 5 1 abnormal body temperature homeostasis 0.334936304100079 0.583281218863301 0.680723839496459 0.451612903225806 5.1 5 1 abnormal T cell proliferation 0.334936304100079 0.583281218863301 0.680723839496459 0.451612903225806 5.1 5 1 abnormal podocyte morphology 0.334936304100079 0.583281218863301 0.680723839496459 0.451612903225806 5.1 5 1 decreased circulating phosphate level 0.306014731947692 0.583281218863301 0.678292682926829 0.45 5.1 5 1 abnormal trachea morphology 0.400187634014124 0.583281218863301 0.678292682926829 0.45 5.1 5 1 decreased skin tensile strength 0.400187634014124 0.583281218863301 0.678292682926829 0.45 5.1 5 1 abnormal physiological neovascularization 0.400187634014124 0.583281218863301 0.678292682926829 0.45 5.1 5 1 kidney atrophy 0.400187634014124 0.583281218863301 0.678292682926829 0.45 5.1 5 1 nuclear cataracts 0.400187634014124 0.583281218863301 0.678292682926829 0.45 5.1 5 1 decreased urine osmolality 0.281821543907069 0.572620638868235 0.676754604280737 0.448979591836735 5.1 5 1 stomach inflammation 0.357668427797323 0.583281218863301 0.67569386038688 0.448275862068966 5.1 5 1 increased susceptibility to bacterial infection induced morbidity/mortality 0.249887321416411 0.520816683722935 0.669918699186992 0.444444444444444 5.1 5 1 abnormal epidermis stratum granulosum morphology 0.345326669229263 0.583281218863301 0.669918699186992 0.444444444444444 5.1 5 1 abnormal mammary gland morphology 0.432501699091164 0.622777410413471 0.669918699186992 0.444444444444444 5.1 5 1 abnormal iron level 0.432501699091164 0.622777410413471 0.669918699186992 0.444444444444444 5.1 5 1 abnormal macrophage chemotaxis 0.432501699091164 0.622777410413471 0.669918699186992 0.444444444444444 5.1 5 1 impaired leukocyte tethering or rolling 0.432501699091164 0.622777410413471 0.669918699186992 0.444444444444444 5.1 5 1 abnormal NK cell physiology 0.283080085774019 0.572620638868235 0.667173130747701 0.442622950819672 5.1 5 1 lung inflammation 0.1778474057607 0.385697839433079 0.664992826398852 0.441176470588235 5.1 5 1 increased susceptibility to viral infection induced morbidity/mortality 0.367238834772132 0.583281218863301 0.664992826398852 0.441176470588235 5.1 5 1 decreased inflammatory response 0.250574897720063 0.522031036916798 0.663937282229965 0.44047619047619 5.1 5 1 abnormal feces composition 0.409501290711699 0.592057227925226 0.663219512195122 0.44 5.1 5 1 abnormal stomach mucosa morphology 0.409501290711699 0.592057227925226 0.663219512195122 0.44 5.1 5 1 increased tumor growth/size 0.353812508902783 0.583281218863301 0.661748958953004 0.439024390243902 5.1 5 1 abnormal crypts of Lieberkuhn morphology 0.390855125859332 0.583281218863301 0.659451219512195 0.4375 5.1 5 1 mixed cellular infiltration to dermis 0.468966454824947 0.659629096057141 0.659451219512195 0.4375 5.1 5 1 abnormal meiosis 0.468966454824947 0.659629096057141 0.659451219512195 0.4375 5.1 5 1 abnormal wound healing 0.468966454824947 0.659629096057141 0.659451219512195 0.4375 5.1 5 1 sepsis 0.468966454824947 0.659629096057141 0.659451219512195 0.4375 5.1 5 1 decreased creatinine clearance 0.468966454824947 0.659629096057141 0.659451219512195 0.4375 5.1 5 1 kidney degeneration 0.468966454824947 0.659629096057141 0.659451219512195 0.4375 5.1 5 1 increased autoantibody level 0.37493047439934 0.583281218863301 0.65703564727955 0.435897435897436 5.1 5 1 increased eosinophil cell number 0.320414734564685 0.583281218863301 0.656412273800157 0.435483870967742 5.1 5 1 abnormal blood vessel physiology 0.439187549079302 0.631308308774784 0.655355249204666 0.434782608695652 5.1 5 1 abnormal retinal cone cell morphology 0.439187549079302 0.631308308774784 0.655355249204666 0.434782608695652 5.1 5 1 conjunctivitis 0.439187549079302 0.631308308774784 0.655355249204666 0.434782608695652 5.1 5 1 abnormal sacral vertebrae morphology 0.439187549079302 0.631308308774784 0.655355249204666 0.434782608695652 5.1 5 1 abnormal crista ampullaris morphology 0.439187549079302 0.631308308774784 0.655355249204666 0.434782608695652 5.1 5 1 abnormal B cell morphology 0.439187549079302 0.631308308774784 0.655355249204666 0.434782608695652 5.1 5 1 gastrointestinal hemorrhage 0.416350196918333 0.601784494383703 0.653170731707317 0.433333333333333 5.1 5 1 abnormal gametogenesis 0.381276850527402 0.583281218863301 0.650886917960089 0.431818181818182 5.1 5 1 abnormal epidermis stratum corneum morphology 0.386621425677874 0.583281218863301 0.645993031358885 0.428571428571429 5.1 5 1 abnormal clavicle morphology 0.471877133855932 0.663535540116807 0.645993031358885 0.428571428571429 5.1 5 1 abnormal blood flow velocity 0.510534675373608 0.704078205905904 0.645993031358885 0.428571428571429 5.1 5 1 abnormal spleen periarteriolar lymphoid sheath morphology 0.510534675373608 0.704078205905904 0.645993031358885 0.428571428571429 5.1 5 1 decreased vascular permeability 0.510534675373608 0.704078205905904 0.645993031358885 0.428571428571429 5.1 5 1 enlarged stomach 0.510534675373608 0.704078205905904 0.645993031358885 0.428571428571429 5.1 5 1 abnormal respiratory motile cilium physiology 0.510534675373608 0.704078205905904 0.645993031358885 0.428571428571429 5.1 5 1 abnormal stomach morphology 0.473795355394773 0.665480489296723 0.637711069418386 0.423076923076923 5.1 5 1 abnormal kidney cortex morphology 0.473795355394773 0.665480489296723 0.637711069418386 0.423076923076923 5.1 5 1 increased susceptibility to otitis media 0.473795355394773 0.665480489296723 0.637711069418386 0.423076923076923 5.1 5 1 abnormal ocular fundus morphology 0.473795355394773 0.665480489296723 0.637711069418386 0.423076923076923 5.1 5 1 abnormal neural crest cell migration 0.508036804372207 0.704078205905904 0.634659820282413 0.421052631578947 5.1 5 1 osteoarthritis 0.508036804372207 0.704078205905904 0.634659820282413 0.421052631578947 5.1 5 1 increased circulating VLDL cholesterol level 0.508036804372207 0.704078205905904 0.634659820282413 0.421052631578947 5.1 5 1 increased liver cholesterol level 0.508036804372207 0.704078205905904 0.634659820282413 0.421052631578947 5.1 5 1 decreased double-negative T cell number 0.475149119509293 0.667193584408336 0.632100708103855 0.419354838709677 5.1 5 1 abnormal kidney physiology 0.45432855453938 0.64285681423021 0.628048780487805 0.416666666666667 5.1 5 1 increased circulating total protein level 0.506224863138838 0.704078205905904 0.628048780487805 0.416666666666667 5.1 5 1 abnormal cellular extravasation 0.506224863138838 0.704078205905904 0.628048780487805 0.416666666666667 5.1 5 1 abnormal enteric nervous system morphology 0.558522115834517 0.749972341775094 0.628048780487805 0.416666666666667 5.1 5 1 increased circulating parathyroid hormone level 0.558522115834517 0.749972341775094 0.628048780487805 0.416666666666667 5.1 5 1 increased hepatocyte proliferation 0.558522115834517 0.749972341775094 0.628048780487805 0.416666666666667 5.1 5 1 hemoperitoneum 0.558522115834517 0.749972341775094 0.628048780487805 0.416666666666667 5.1 5 1 hydrometra 0.558522115834517 0.749972341775094 0.628048780487805 0.416666666666667 5.1 5 1 decreased compensatory feeding amount 0.558522115834517 0.749972341775094 0.628048780487805 0.416666666666667 5.1 5 1 abnormal cholesterol homeostasis 0.476907642873892 0.669473906122351 0.62498512790006 0.414634146341463 5.1 5 1 increased susceptibility to induced arthritis 0.504806951569821 0.704078205905904 0.623717409587889 0.413793103448276 5.1 5 1 abnormal thrombosis 0.477963753949444 0.670767186431167 0.620659971305595 0.411764705882353 5.1 5 1 decreased cytotoxic T cell cytolysis 0.503641916735262 0.704078205905904 0.620659971305595 0.411764705882353 5.1 5 1 enlarged sebaceous gland 0.548238781084186 0.737557581366638 0.620659971305595 0.411764705882353 5.1 5 1 increased hepatoma incidence 0.548238781084186 0.737557581366638 0.620659971305595 0.411764705882353 5.1 5 1 abnormal humoral immune response 0.447972797948162 0.64152630400885 0.617282229965157 0.40952380952381 5.1 5 1 decreased sensitivity to induced morbidity/mortality 0.501789003704545 0.704004594875948 0.616629711751663 0.409090909090909 5.1 5 1 intestinal ulcer 0.541498118387118 0.728883425047595 0.616629711751663 0.409090909090909 5.1 5 1 abnormal cytotoxic T cell physiology 0.527229767765851 0.709869579062276 0.610104529616725 0.404761904761905 5.1 5 1 impaired natural killer cell mediated cytotoxicity 0.521519865659657 0.704078205905904 0.608215661103979 0.403508771929825 5.1 5 1 increased pre-B cell number 0.570707244756931 0.76592083697484 0.602926829268293 0.4 5.1 5 1 brain inflammation 0.579936251277596 0.77185201982505 0.602926829268293 0.4 5.1 5 1 decreased salivation 0.593188487821762 0.788014079282581 0.602926829268293 0.4 5.1 5 1 abnormal enteric neuron morphology 0.593188487821762 0.788014079282581 0.602926829268293 0.4 5.1 5 1 vagina atresia 0.593188487821762 0.788014079282581 0.602926829268293 0.4 5.1 5 1 abnormal respiratory system morphology 0.593188487821762 0.788014079282581 0.602926829268293 0.4 5.1 5 1 abnormal cricoid cartilage morphology 0.593188487821762 0.788014079282581 0.602926829268293 0.4 5.1 5 1 joint inflammation 0.593188487821762 0.788014079282581 0.602926829268293 0.4 5.1 5 1 abnormal ear development 0.593188487821762 0.788014079282581 0.602926829268293 0.4 5.1 5 1 decreased IgG level 0.556887149325547 0.74898988047975 0.597495056031641 0.396396396396396 5.1 5 1 abnormal immune system physiology 0.567261724297921 0.761502179811699 0.595633359559402 0.395161290322581 5.1 5 1 delayed wound healing 0.596754177304057 0.789527711795951 0.589819724284199 0.391304347826087 5.1 5 1 abnormal regulatory T cell physiology 0.607269198656429 0.789527711795951 0.589819724284199 0.391304347826087 5.1 5 1 abnormal systemic arterial blood pressure 0.61059573715993 0.789527711795951 0.586178861788618 0.388888888888889 5.1 5 1 abnormal inflammatory response 0.612248548502802 0.789527711795951 0.586178861788618 0.388888888888889 5.1 5 1 increased circulating renin level 0.621889651443382 0.789527711795951 0.586178861788618 0.388888888888889 5.1 5 1 abnormal intestine physiology 0.619754333018438 0.789527711795951 0.583477576711251 0.387096774193548 5.1 5 1 increased susceptibility to injury 0.633927090356308 0.789527711795951 0.579737335834897 0.384615384615385 5.1 5 1 decreased Peyer's patch number 0.63127717560828 0.789527711795951 0.579737335834897 0.384615384615385 5.1 5 1 abnormal sympathetic ganglion morphology 0.643754200174517 0.794906216398169 0.579737335834897 0.384615384615385 5.1 5 1 abnormal vestibulocochlear ganglion morphology 0.643754200174517 0.794906216398169 0.579737335834897 0.384615384615385 5.1 5 1 small otic vesicle 0.643754200174517 0.794906216398169 0.579737335834897 0.384615384615385 5.1 5 1 decreased follicle stimulating hormone level 0.643754200174517 0.794906216398169 0.579737335834897 0.384615384615385 5.1 5 1 increased renin activity 0.643754200174517 0.794906216398169 0.579737335834897 0.384615384615385 5.1 5 1 decreased susceptibility to injury 0.653312419416561 0.805646707440192 0.576327116212339 0.382352941176471 5.1 5 1 increased acute inflammation 0.646434169690927 0.798017368290908 0.574216027874564 0.380952380952381 5.1 5 1 abnormal primitive streak formation 0.667895799966983 0.812813504118332 0.565243902439024 0.375 5.1 5 1 abnormal bone marrow cell number 0.667721707619852 0.812800463765295 0.565243902439024 0.375 5.1 5 1 abnormal pituitary gland morphology 0.667721707619852 0.812800463765295 0.565243902439024 0.375 5.1 5 1 increased circulating estradiol level 0.667721707619852 0.812800463765295 0.565243902439024 0.375 5.1 5 1 abnormal pancreatic alpha cell morphology 0.667721707619852 0.812800463765295 0.565243902439024 0.375 5.1 5 1 abnormal fertilization 0.667721707619852 0.812800463765295 0.565243902439024 0.375 5.1 5 1 abnormal lymphatic vessel morphology 0.671912558467626 0.817301950703285 0.565243902439024 0.375 5.1 5 1 decreased susceptibility to parasitic infection 0.671912558467626 0.817301950703285 0.565243902439024 0.375 5.1 5 1 altered susceptibility to infection 0.688303812234901 0.832760570493344 0.555327342747112 0.368421052631579 5.1 5 1 decreased sensitivity to xenobiotic induced morbidity/mortality 0.719691067695334 0.868201518376403 0.548115299334812 0.363636363636364 5.1 5 1 abnormal antigen presentation 0.717765047286132 0.866088069427239 0.538327526132404 0.357142857142857 5.1 5 1 decreased coping response 0.717765047286132 0.866088069427239 0.538327526132404 0.357142857142857 5.1 5 1 abnormal renal reabsorbtion 0.717765047286132 0.866088069427239 0.538327526132404 0.357142857142857 5.1 5 1 abnormal spleen germinal center morphology 0.737181786293487 0.888655048899951 0.538327526132404 0.357142857142857 5.1 5 1 autoimmune response 0.750518349228905 0.904293724246502 0.534854445318647 0.354838709677419 5.1 5 1 abnormal hair shaft morphology 0.780949769393608 0.904781417788346 0.533841463414634 0.354166666666667 5.1 5 1 aminoaciduria 0.732894213002941 0.883700608262151 0.531994261119082 0.352941176470588 5.1 5 1 abnormal tendon morphology 0.732894213002941 0.883700608262151 0.531994261119082 0.352941176470588 5.1 5 1 absent placental labyrinth 0.746655575827295 0.899857434530231 0.527560975609756 0.35 5.1 5 1 abnormal immune system morphology 0.803580294342122 0.928212668760636 0.524284199363733 0.347826086956522 5.1 5 1 abnormal leukocyte cell number 0.77089287285965 0.904781417788346 0.521763602251407 0.346153846153846 5.1 5 1 increased double-positive T cell number 0.781666842076749 0.904781417788346 0.519764507989907 0.344827586206897 5.1 5 1 increased susceptibility to parasitic infection 0.878190182683214 0.988460669422848 0.519186991869919 0.344444444444444 5.1 5 1 abnormal stomach glandular epithelium morphology 0.788396493782721 0.910885405612875 0.502439024390244 0.333333333333333 5.1 5 1 abnormal Peyer's patch follicle morphology 0.788396493782721 0.910885405612875 0.502439024390244 0.333333333333333 5.1 5 1 abnormal T cell subpopulation ratio 0.827693682736696 0.955844027765799 0.502439024390244 0.333333333333333 5.1 5 1 abnormal leukocyte adhesion 0.841216722160953 0.964742552501323 0.502439024390244 0.333333333333333 5.1 5 1 decreased osteoblast cell number 0.858742738994865 0.980123271850423 0.487661406025825 0.323529411764706 5.1 5 1 increased activated T cell number 0.838938316176588 0.96341611027418 0.47960088691796 0.318181818181818 5.1 5 1 abnormal nail morphology 0.834593116035562 0.960912000064087 0.47599486521181 0.315789473684211 5.1 5 1 abnormal intestinal absorption 0.83111315401762 0.957126838249459 0.471036585365854 0.3125 5.1 5 1 abnormal intestinal lipid absorption 0.83111315401762 0.957126838249459 0.471036585365854 0.3125 5.1 5 1 abnormal circulating glucose level 0.878867889839248 0.988999717699674 0.467788057190917 0.310344827586207 5.1 5 1 abnormal thymocyte activation 0.872280633267676 0.982475922686595 0.45219512195122 0.3 5.1 5 1 increased urine calcium level 0.872280633267676 0.982475922686595 0.45219512195122 0.3 5.1 5 1 abnormal circulating cytokine level 0.872280633267676 0.982475922686595 0.45219512195122 0.3 5.1 5 1 nephrocalcinosis 0.872037712773736 0.982475922686595 0.443328550932568 0.294117647058824 5.1 5 1 decreased IgA level 0.963805326821179 1 0.434803001876173 0.288461538461538 5.1 5 1 hypoalgesia 0.902486375016555 1 0.430662020905923 0.285714285714286 5.1 5 1 abnormal bile salt homeostasis 0.902486375016555 1 0.430662020905923 0.285714285714286 5.1 5 1 decreased airway responsiveness 0.972782502518477 1 0.342572062084257 0.227272727272727 5.1 5 1 decreased susceptibility to bacterial infection induced morbidity/mortality 0.987035829498673 1 0.34036191974823 0.225806451612903 5.1 5 1 abnormal kidney blood vessel morphology 6.48047419281694e-05 0.000736081258202381 0.991078765113276 1 5.4 5 4 testis degeneration 6.48047419281694e-05 0.000736081258202381 0.991078765113276 1 5.4 5 4 growth retardation of molars 0.00805590658260988 0.0405649142191135 0.991078765113276 1 5.4 5 4 failure of atrioventricular cushion closure 0.00805590658260988 0.0405649142191135 0.991078765113276 1 5.4 5 4 cellular necrosis 0.00805590658260988 0.0405649142191135 0.991078765113276 1 5.4 5 4 broad head 0.00805590658260988 0.0405649142191135 0.991078765113276 1 5.4 5 4 absent hair follicles 0.00805590658260988 0.0405649142191135 0.991078765113276 1 5.4 5 4 skin photosensitivity 0.00805590658260988 0.0405649142191135 0.991078765113276 1 5.4 5 4 abnormal circulating alanine transaminase level 0.00805590658260988 0.0405649142191135 0.991078765113276 1 5.4 5 4 abnormal tumor incidence 0.00805590658260988 0.0405649142191135 0.991078765113276 1 5.4 5 4 abnormal adrenal gland physiology 0.00805590658260988 0.0405649142191135 0.991078765113276 1 5.4 5 4 increased retinal ganglion cell number 0.00805590658260988 0.0405649142191135 0.991078765113276 1 5.4 5 4 decreased mortality induced by ionizing radiation 0.00805590658260988 0.0405649142191135 0.991078765113276 1 5.4 5 4 aorta coarctation 0.00805590658260988 0.0405649142191135 0.991078765113276 1 5.4 5 4 increased cell nucleus count 0.00805590658260988 0.0405649142191135 0.991078765113276 1 5.4 5 4 abnormal central pattern generator function 0.00805590658260988 0.0405649142191135 0.991078765113276 1 5.4 5 4 abnormal nephron morphology 0.00805590658260988 0.0405649142191135 0.991078765113276 1 5.4 5 4 abnormal Purkinje cell innervation 0.00805590658260988 0.0405649142191135 0.991078765113276 1 5.4 5 4 absent deltoid tuberosity 0.00805590658260988 0.0405649142191135 0.991078765113276 1 5.4 5 4 abnormal cochlear nerve compound action potential 0.00805590658260988 0.0405649142191135 0.991078765113276 1 5.4 5 4 absent fibula 0.00805590658260988 0.0405649142191135 0.991078765113276 1 5.4 5 4 decreased tidal volume 0.00805590658260988 0.0405649142191135 0.991078765113276 1 5.4 5 4 heart hemorrhage 0.00805590658260988 0.0405649142191135 0.991078765113276 1 5.4 5 4 decreased DN2 thymocyte number 0.00805590658260988 0.0405649142191135 0.991078765113276 1 5.4 5 4 abnormal outer hair cell kinocilium morphology 0.00805590658260988 0.0405649142191135 0.991078765113276 1 5.4 5 4 abnormal brain ependyma motile cilium physiology 0.00805590658260988 0.0405649142191135 0.991078765113276 1 5.4 5 4 abnormal pup retrieval 3.25342355230066e-05 0.000403838958701482 0.991078765113276 1 5.4 5 4 pup cannibalization 0.000129080387872314 0.00134346219595139 0.991078765113276 1 5.4 5 4 excessive scratching 0.000129080387872314 0.00134346219595139 0.991078765113276 1 5.4 5 4 abnormal respiratory function 0.000257099384090563 0.00244097220582166 0.991078765113276 1 5.4 5 4 abnormal AMPA-mediated synaptic currents 0.000257099384090563 0.00244097220582166 0.991078765113276 1 5.4 5 4 absent ovary 0.000257099384090563 0.00244097220582166 0.991078765113276 1 5.4 5 4 increased osteosarcoma incidence 0.000257099384090563 0.00244097220582166 0.991078765113276 1 5.4 5 4 abnormal fear/anxiety-related behavior 0.000512069737044885 0.00434497480684813 0.991078765113276 1 5.4 5 4 palatal shelf hypoplasia 0.000512069737044885 0.00434497480684813 0.991078765113276 1 5.4 5 4 abnormal palatal shelf elevation 0.000512069737044885 0.00434497480684813 0.991078765113276 1 5.4 5 4 common atrioventricular valve 0.000512069737044885 0.00434497480684813 0.991078765113276 1 5.4 5 4 rhinitis 0.00101986921905921 0.00777367409278748 0.991078765113276 1 5.4 5 4 decreased incidence of induced tumors 0.00101986921905921 0.00777367409278748 0.991078765113276 1 5.4 5 4 abnormal neuron specification 0.00101986921905921 0.00777367409278748 0.991078765113276 1 5.4 5 4 abnormal embryonic erythrocyte morphology 0.00101986921905921 0.00777367409278748 0.991078765113276 1 5.4 5 4 osteosclerosis 0.00101986921905921 0.00777367409278748 0.991078765113276 1 5.4 5 4 abnormal developmental vascular remodeling 0.00101986921905921 0.00777367409278748 0.991078765113276 1 5.4 5 4 thin ventricle myocardium compact layer 0.00101986921905921 0.00777367409278748 0.991078765113276 1 5.4 5 4 large anterior fontanelle 0.0160427571318085 0.0695152957111566 0.991078765113276 1 5.4 5 4 arrest of tooth development 0.0160427571318085 0.0695152957111566 0.991078765113276 1 5.4 5 4 abnormal urethra morphology 0.0160427571318085 0.0695152957111566 0.991078765113276 1 5.4 5 4 absent limbs 0.0160427571318085 0.0695152957111566 0.991078765113276 1 5.4 5 4 thin tail 0.0160427571318085 0.0695152957111566 0.991078765113276 1 5.4 5 4 epidermal necrosis 0.0160427571318085 0.0695152957111566 0.991078765113276 1 5.4 5 4 absent ectoplacental cone 0.0160427571318085 0.0695152957111566 0.991078765113276 1 5.4 5 4 reduced NMDA-mediated synaptic currents 0.0160427571318085 0.0695152957111566 0.991078765113276 1 5.4 5 4 chromatolysis 0.0160427571318085 0.0695152957111566 0.991078765113276 1 5.4 5 4 increased post-tetanic potentiation 0.0160427571318085 0.0695152957111566 0.991078765113276 1 5.4 5 4 abnormal hippocampal fimbria morphology 0.0160427571318085 0.0695152957111566 0.991078765113276 1 5.4 5 4 decreased liver function 0.0160427571318085 0.0695152957111566 0.991078765113276 1 5.4 5 4 impaired granulosa cell differentiation 0.0160427571318085 0.0695152957111566 0.991078765113276 1 5.4 5 4 abnormal leukocyte tethering or rolling 0.0160427571318085 0.0695152957111566 0.991078765113276 1 5.4 5 4 abnormal metopic suture morphology 0.0160427571318085 0.0695152957111566 0.991078765113276 1 5.4 5 4 abnormal heart left atrium morphology 0.0160427571318085 0.0695152957111566 0.991078765113276 1 5.4 5 4 decreased prostate gland weight 0.0160427571318085 0.0695152957111566 0.991078765113276 1 5.4 5 4 abnormal blastocoele morphology 0.0160427571318085 0.0695152957111566 0.991078765113276 1 5.4 5 4 osteomyelitis 0.0160427571318085 0.0695152957111566 0.991078765113276 1 5.4 5 4 abnormal heart size 0.0160427571318085 0.0695152957111566 0.991078765113276 1 5.4 5 4 abnormal dermis papillary layer morphology 0.0160427571318085 0.0695152957111566 0.991078765113276 1 5.4 5 4 abnormal right lung morphology 0.0160427571318085 0.0695152957111566 0.991078765113276 1 5.4 5 4 abnormal neural crest cell morphology 0.0160427571318085 0.0695152957111566 0.991078765113276 1 5.4 5 4 ectopic hippocampus pyramidal cells 0.0160427571318085 0.0695152957111566 0.991078765113276 1 5.4 5 4 increased erythrocyte clearance 0.0160427571318085 0.0695152957111566 0.991078765113276 1 5.4 5 4 abnormal oval cell physiology 0.0160427571318085 0.0695152957111566 0.991078765113276 1 5.4 5 4 kidney microaneurysm 0.0160427571318085 0.0695152957111566 0.991078765113276 1 5.4 5 4 myocardium hypoplasia 0.0160427571318085 0.0695152957111566 0.991078765113276 1 5.4 5 4 abnormal intestinal enteroendocrine cell morphology 0.0160427571318085 0.0695152957111566 0.991078765113276 1 5.4 5 4 absent alveolar lamellar bodies 0.0160427571318085 0.0695152957111566 0.991078765113276 1 5.4 5 4 delayed limb development 0.0160427571318085 0.0695152957111566 0.991078765113276 1 5.4 5 4 abnormal Rathke's pouch development 0.0160427571318085 0.0695152957111566 0.991078765113276 1 5.4 5 4 increased bone trabecular spacing 0.0160427571318085 0.0695152957111566 0.991078765113276 1 5.4 5 4 abnormal vertebral artery origin 0.0160427571318085 0.0695152957111566 0.991078765113276 1 5.4 5 4 abnormal Wolffian duct connection 0.0160427571318085 0.0695152957111566 0.991078765113276 1 5.4 5 4 decreased hippocampus volume 0.0160427571318085 0.0695152957111566 0.991078765113276 1 5.4 5 4 abnormal excitatory synapse morphology 0.0160427571318085 0.0695152957111566 0.991078765113276 1 5.4 5 4 absent neurocranium 0.0319470603624618 0.117469789581114 0.991078765113276 1 5.4 5 4 small hair follicles 0.0319470603624618 0.117469789581114 0.991078765113276 1 5.4 5 4 abnormal pulmonary trunk morphology 0.0319470603624618 0.117469789581114 0.991078765113276 1 5.4 5 4 absent hindlimb 0.0319470603624618 0.117469789581114 0.991078765113276 1 5.4 5 4 ulcerated paws 0.0319470603624618 0.117469789581114 0.991078765113276 1 5.4 5 4 abnormal pineal gland morphology 0.0319470603624618 0.117469789581114 0.991078765113276 1 5.4 5 4 absent prostate gland 0.0319470603624618 0.117469789581114 0.991078765113276 1 5.4 5 4 skin hyperplasia 0.0319470603624618 0.117469789581114 0.991078765113276 1 5.4 5 4 kinked vibrissae 0.0319470603624618 0.117469789581114 0.991078765113276 1 5.4 5 4 abnormal esophagus development 0.0319470603624618 0.117469789581114 0.991078765113276 1 5.4 5 4 increased lysosomal enzyme secretion 0.0319470603624618 0.117469789581114 0.991078765113276 1 5.4 5 4 enhanced NMDA-mediated synaptic currents 0.0319470603624618 0.117469789581114 0.991078765113276 1 5.4 5 4 gastric polyps 0.0319470603624618 0.117469789581114 0.991078765113276 1 5.4 5 4 epidermal cyst 0.0319470603624618 0.117469789581114 0.991078765113276 1 5.4 5 4 absent vas deferens 0.0319470603624618 0.117469789581114 0.991078765113276 1 5.4 5 4 absent uterus 0.0319470603624618 0.117469789581114 0.991078765113276 1 5.4 5 4 ischuria 0.0319470603624618 0.117469789581114 0.991078765113276 1 5.4 5 4 increased heart right ventricle weight 0.0319470603624618 0.117469789581114 0.991078765113276 1 5.4 5 4 scapular bone foramen 0.0319470603624618 0.117469789581114 0.991078765113276 1 5.4 5 4 abnormal olfactory cortex morphology 0.0319470603624618 0.117469789581114 0.991078765113276 1 5.4 5 4 growth retardation of incisors 0.0319470603624618 0.117469789581114 0.991078765113276 1 5.4 5 4 corneal deposits 0.0319470603624618 0.117469789581114 0.991078765113276 1 5.4 5 4 increased placenta apoptosis 0.0319470603624618 0.117469789581114 0.991078765113276 1 5.4 5 4 abnormal mismatch repair 0.0319470603624618 0.117469789581114 0.991078765113276 1 5.4 5 4 enlarged eye anterior chamber 0.0319470603624618 0.117469789581114 0.991078765113276 1 5.4 5 4 abnormal arcus anterior morphology 0.0319470603624618 0.117469789581114 0.991078765113276 1 5.4 5 4 abnormal olfactory bulb granule cell layer morphology 0.0319470603624618 0.117469789581114 0.991078765113276 1 5.4 5 4 abnormal cerebellum lobule morphology 0.0319470603624618 0.117469789581114 0.991078765113276 1 5.4 5 4 decreased DN3 thymocyte number 0.0319470603624618 0.117469789581114 0.991078765113276 1 5.4 5 4 increased response to stress-induced hyperthermia 0.0319470603624618 0.117469789581114 0.991078765113276 1 5.4 5 4 increased mammary gland epithelial cell proliferation 0.0319470603624618 0.117469789581114 0.991078765113276 1 5.4 5 4 increased T follicular helper cell number 0.0319470603624618 0.117469789581114 0.991078765113276 1 5.4 5 4 increased thyroid carcinoma incidence 0.0319470603624618 0.117469789581114 0.991078765113276 1 5.4 5 4 inlet ventricular septal defect 0.0319470603624618 0.117469789581114 0.991078765113276 1 5.4 5 4 calcified aorta 0.0319470603624618 0.117469789581114 0.991078765113276 1 5.4 5 4 aorta hypoplasia 0.0319470603624618 0.117469789581114 0.991078765113276 1 5.4 5 4 ventricular myocardium compact layer hypoplasia 0.0319470603624618 0.117469789581114 0.991078765113276 1 5.4 5 4 absent arcus anterior 0.0319470603624618 0.117469789581114 0.991078765113276 1 5.4 5 4 pale lung 0.0319470603624618 0.117469789581114 0.991078765113276 1 5.4 5 4 alveolitis 0.0319470603624618 0.117469789581114 0.991078765113276 1 5.4 5 4 fused right lung lobes 0.0319470603624618 0.117469789581114 0.991078765113276 1 5.4 5 4 abnormal nephrogenic mesenchyme morphogenesis 0.0319470603624618 0.117469789581114 0.991078765113276 1 5.4 5 4 abnormal lung alveolus development 0.0319470603624618 0.117469789581114 0.991078765113276 1 5.4 5 4 abnormal circadian regulation of heart rate 0.0319470603624618 0.117469789581114 0.991078765113276 1 5.4 5 4 abnormal circadian regulation of systemic arterial blood pressure 0.0319470603624618 0.117469789581114 0.991078765113276 1 5.4 5 4 midface hypoplasia 0.0319470603624618 0.117469789581114 0.991078765113276 1 5.4 5 4 delayed optic fissure closure 0.0319470603624618 0.117469789581114 0.991078765113276 1 5.4 5 4 decreased Paneth cell number 0.0319470603624618 0.117469789581114 0.991078765113276 1 5.4 5 4 abnormal mitophagy 0.0319470603624618 0.117469789581114 0.991078765113276 1 5.4 5 4 decreased small intestinal villus height 0.0319470603624618 0.117469789581114 0.991078765113276 1 5.4 5 4 abnormal ciliary process morphology 0.0319470603624618 0.117469789581114 0.991078765113276 1 5.4 5 4 abnormal mitral valve morphology 4.11590972055926e-06 6.60062824931029e-05 0.991078765113276 1 5.4 5 4 delayed kidney development 4.11590972055926e-06 6.60062824931029e-05 0.991078765113276 1 5.4 5 4 abnormal involuntary movement 8.1991746016687e-06 0.000122864137479825 0.991078765113276 1 5.4 5 4 heart hyperplasia 0.00203117414788849 0.0134376215235974 0.991078765113276 1 5.4 5 4 abnormal NMDA-mediated synaptic currents 0.00203117414788849 0.0134376215235974 0.991078765113276 1 5.4 5 4 premature neuronal precursor differentiation 0.00203117414788849 0.0134376215235974 0.991078765113276 1 5.4 5 4 decreased fear-related response 0.00203117414788849 0.0134376215235974 0.991078765113276 1 5.4 5 4 abnormal thymus physiology 0.00203117414788849 0.0134376215235974 0.991078765113276 1 5.4 5 4 decreased cellular sensitivity to ionizing radiation 0.00203117414788849 0.0134376215235974 0.991078765113276 1 5.4 5 4 increased neuronal precursor cell number 0.00203117414788849 0.0134376215235974 0.991078765113276 1 5.4 5 4 abnormal CNS synapse formation 0.00203117414788849 0.0134376215235974 0.991078765113276 1 5.4 5 4 liver hyperplasia 0.00203117414788849 0.0134376215235974 0.991078765113276 1 5.4 5 4 enhanced conditioned place preference behavior 0.00203117414788849 0.0134376215235974 0.991078765113276 1 5.4 5 4 fusion of atlas and occipital bones 0.00203117414788849 0.0134376215235974 0.991078765113276 1 5.4 5 4 decreased effector memory CD4-positive, alpha-beta T cell number 0.00203117414788849 0.0134376215235974 0.991078765113276 1 5.4 5 4 reduced AMPA-mediated synaptic currents 0.00203117414788849 0.0134376215235974 0.991078765113276 1 5.4 5 4 cerebellum atrophy 0.00203117414788849 0.0134376215235974 0.991078765113276 1 5.4 5 4 abnormal ear pigmentation 0.00404517336463805 0.0232119232861295 0.991078765113276 1 5.4 5 4 absent mammary gland 0.00404517336463805 0.0232119232861295 0.991078765113276 1 5.4 5 4 poor grooming 0.00404517336463805 0.0232119232861295 0.991078765113276 1 5.4 5 4 decreased aerobic running capacity 0.00404517336463805 0.0232119232861295 0.991078765113276 1 5.4 5 4 early eyelid opening 0.00404517336463805 0.0232119232861295 0.991078765113276 1 5.4 5 4 abnormal cellular cholesterol metabolism 0.00404517336463805 0.0232119232861295 0.991078765113276 1 5.4 5 4 abnormal neuron apoptosis 0.00404517336463805 0.0232119232861295 0.991078765113276 1 5.4 5 4 colon polyps 0.00404517336463805 0.0232119232861295 0.991078765113276 1 5.4 5 4 liver failure 0.00404517336463805 0.0232119232861295 0.991078765113276 1 5.4 5 4 abnormal ovary development 0.00404517336463805 0.0232119232861295 0.991078765113276 1 5.4 5 4 tau protein deposits 0.00404517336463805 0.0232119232861295 0.991078765113276 1 5.4 5 4 abnormal lateral ganglionic eminence morphology 0.00404517336463805 0.0232119232861295 0.991078765113276 1 5.4 5 4 abnormal NK cell morphology 0.00404517336463805 0.0232119232861295 0.991078765113276 1 5.4 5 4 abnormal ilium morphology 0.00404517336463805 0.0232119232861295 0.991078765113276 1 5.4 5 4 abnormal meiotic spindle morphology 0.00404517336463805 0.0232119232861295 0.991078765113276 1 5.4 5 4 abnormal olfactory bulb glomerular layer morphology 0.00404517336463805 0.0232119232861295 0.991078765113276 1 5.4 5 4 abnormal cerebellum deep nucleus morphology 0.00404517336463805 0.0232119232861295 0.991078765113276 1 5.4 5 4 increased caudal vertebrae number 0.00404517336463805 0.0232119232861295 0.991078765113276 1 5.4 5 4 pleural effusion 0.00404517336463805 0.0232119232861295 0.991078765113276 1 5.4 5 4 abnormal visual evoked potential 0.00404517336463805 0.0232119232861295 0.991078765113276 1 5.4 5 4 abnormal anterior commissure pars posterior morphology 0.00404517336463805 0.0232119232861295 0.991078765113276 1 5.4 5 4 abnormal umbilical vein topology 0.00404517336463805 0.0232119232861295 0.991078765113276 1 5.4 5 4 increased brain apoptosis 0.00404517336463805 0.0232119232861295 0.991078765113276 1 5.4 5 4 abnormal atrioventricular cushion morphology 2.3131318366196e-07 4.8352230618414e-06 0.954372144183155 0.962962962962963 5.4 5 4 abnormal nest building behavior 8.52707754906928e-07 1.57119299283777e-05 0.951435614508745 0.96 5.4 5 4 abnormal occipital bone morphology 5.96540126690648e-06 9.10364150394471e-05 0.9460297303354 0.954545454545455 5.4 5 4 abnormal scapula morphology 1.13676826804206e-05 0.000163497242867614 0.94388453820312 0.952380952380952 5.4 5 4 thick ventricular wall 4.53751090388459e-10 1.63580556136419e-08 0.942733459497994 0.951219512195122 5.4 5 4 decreased paired-pulse facilitation 2.16169305385495e-05 0.000279335660855282 0.941524826857612 0.95 5.4 5 4 abnormal postnatal subventricular zone morphology 2.16169305385495e-05 0.000279335660855282 0.941524826857612 0.95 5.4 5 4 abnormal excitatory postsynaptic currents 6.34928948118346e-18 6.86689460193212e-16 0.940254213056185 0.948717948717949 5.4 5 4 abnormal cell morphology 1.84315122724675e-25 4.36651302645361e-23 0.938916724844156 0.947368421052632 5.4 5 4 increased liver adenoma incidence 4.10126987179208e-05 0.000494039167364784 0.938916724844156 0.947368421052632 5.4 5 4 abnormal contextual conditioning behavior 9.27665217081887e-13 4.90971750530041e-11 0.937019923379825 0.945454545454545 5.4 5 4 small thoracic cage 7.7614677580529e-05 0.000863832261662487 0.936018833718094 0.944444444444444 5.4 5 4 increased effector memory CD4-positive, alpha-beta T cell number 7.7614677580529e-05 0.000863832261662487 0.936018833718094 0.944444444444444 5.4 5 4 impaired synaptic plasticity 3.91878426321385e-08 9.65146124232123e-07 0.93278001422426 0.941176470588235 5.4 5 4 abnormal adipose tissue morphology 0.00014647149627387 0.00148713406931123 0.93278001422426 0.941176470588235 5.4 5 4 abnormal interatrial septum morphology 0.00014647149627387 0.00148713406931123 0.93278001422426 0.941176470588235 5.4 5 4 abnormal dorsal-ventral axis patterning 0.00014647149627387 0.00148713406931123 0.93278001422426 0.941176470588235 5.4 5 4 abnormal glutamate-mediated receptor currents 0.00014647149627387 0.00148713406931123 0.93278001422426 0.941176470588235 5.4 5 4 absence seizures 0.00014647149627387 0.00148713406931123 0.93278001422426 0.941176470588235 5.4 5 4 increased brain size 0.00014647149627387 0.00148713406931123 0.93278001422426 0.941176470588235 5.4 5 4 increased trabecular bone mass 0.00014647149627387 0.00148713406931123 0.93278001422426 0.941176470588235 5.4 5 4 poor circulation 0.00027555515963231 0.00258092127021665 0.929136342293696 0.9375 5.4 5 4 kidney degeneration 0.00027555515963231 0.00258092127021665 0.929136342293696 0.9375 5.4 5 4 impaired somite development 0.00027555515963231 0.00258092127021665 0.929136342293696 0.9375 5.4 5 4 abnormal object recognition memory 2.58593200844473e-07 5.27254579590678e-06 0.927138199622097 0.935483870967742 5.4 5 4 failure to gastrulate 2.70253208975206e-10 1.01090955988846e-08 0.926443193475454 0.934782608695652 5.4 5 4 absent incisors 0.000516591831600446 0.00434497480684813 0.925006847439058 0.933333333333333 5.4 5 4 abnormal apical ectodermal ridge morphology 0.000516591831600446 0.00434497480684813 0.925006847439058 0.933333333333333 5.4 5 4 abnormal trophectoderm morphology 0.000516591831600446 0.00434497480684813 0.925006847439058 0.933333333333333 5.4 5 4 immune system phenotype 0.000516591831600446 0.00434497480684813 0.925006847439058 0.933333333333333 5.4 5 4 absent chorion 0.000516591831600446 0.00434497480684813 0.925006847439058 0.933333333333333 5.4 5 4 abnormal coronary vessel morphology 0.000516591831600446 0.00434497480684813 0.925006847439058 0.933333333333333 5.4 5 4 heterochrony 0.000516591831600446 0.00434497480684813 0.925006847439058 0.933333333333333 5.4 5 4 absent long term depression 9.00720707771891e-07 1.64745791219307e-05 0.922728505450292 0.931034482758621 5.4 5 4 amyloid beta deposits 0.000964663785146198 0.00751048878106781 0.920287424748042 0.928571428571429 5.4 5 4 abnormal voluntary movement 0.000964663785146198 0.00751048878106781 0.920287424748042 0.928571428571429 5.4 5 4 decreased CNS synapse formation 0.000964663785146198 0.00751048878106781 0.920287424748042 0.928571428571429 5.4 5 4 abnormal cell differentiation 6.02493938020545e-09 1.77826931538454e-07 0.918560806690353 0.926829268292683 5.4 5 4 decreased susceptibility to pharmacologically induced seizures 3.10840626804607e-06 5.05369973317948e-05 0.917665523253034 0.925925925925926 5.4 5 4 abnormal grip strength 0.00179332733870955 0.0122552246017582 0.91484193702764 0.923076923076923 5.4 5 4 abnormal pulmonary alveolus epithelial cell morphology 0.00179332733870955 0.0122552246017582 0.91484193702764 0.923076923076923 5.4 5 4 increased synaptic depression 0.00179332733870955 0.0122552246017582 0.91484193702764 0.923076923076923 5.4 5 4 tracheoesophageal fistula 0.00179332733870955 0.0122552246017582 0.91484193702764 0.923076923076923 5.4 5 4 abnormal retinal inner plexiform layer morphology 0.00179332733870955 0.0122552246017582 0.91484193702764 0.923076923076923 5.4 5 4 absent hypoglossal nerve 0.00179332733870955 0.0122552246017582 0.91484193702764 0.923076923076923 5.4 5 4 abnormal dendritic spine morphology 1.42695728896208e-10 5.81894468244783e-09 0.913347097261255 0.92156862745098 5.4 5 4 impaired branching involved in ureteric bud morphogenesis 3.79945854908261e-08 9.40413247845074e-07 0.912835704709596 0.921052631578947 5.4 5 4 increased cellular sensitivity to ionizing radiation 1.06136250232524e-05 0.000155209062356386 0.911792463904214 0.92 5.4 5 4 decreased body height 1.95240070746186e-05 0.000254462783264997 0.908488868020503 0.916666666666667 5.4 5 4 abnormal impulse conducting system conduction 1.95240070746186e-05 0.000254462783264997 0.908488868020503 0.916666666666667 5.4 5 4 increased hemangiosarcoma incidence 1.95240070746186e-05 0.000254462783264997 0.908488868020503 0.916666666666667 5.4 5 4 mesocardia 0.00331674361954243 0.020447087369546 0.908488868020503 0.916666666666667 5.4 5 4 abnormal mating frequency 0.00331674361954243 0.020447087369546 0.908488868020503 0.916666666666667 5.4 5 4 abnormal thymus involution 0.00331674361954243 0.020447087369546 0.908488868020503 0.916666666666667 5.4 5 4 abnormal corticospinal tract morphology 0.00331674361954243 0.020447087369546 0.908488868020503 0.916666666666667 5.4 5 4 decreased synaptic depression 0.00331674361954243 0.020447087369546 0.908488868020503 0.916666666666667 5.4 5 4 stria vascularis degeneration 0.00331674361954243 0.020447087369546 0.908488868020503 0.916666666666667 5.4 5 4 abnormal cochlear outer hair cell physiology 0.00331674361954243 0.020447087369546 0.908488868020503 0.916666666666667 5.4 5 4 abnormal somatic nervous system physiology 0.00331674361954243 0.020447087369546 0.908488868020503 0.916666666666667 5.4 5 4 decreased keratinocyte proliferation 0.00331674361954243 0.020447087369546 0.908488868020503 0.916666666666667 5.4 5 4 persistent right dorsal aorta 0.00331674361954243 0.020447087369546 0.908488868020503 0.916666666666667 5.4 5 4 reduced long term depression 1.28359907721468e-07 2.83818018184136e-06 0.908488868020503 0.916666666666667 5.4 5 4 abnormal excitatory postsynaptic potential 1.0969100520095e-15 8.52676173241761e-14 0.906474480286533 0.914634146341463 5.4 5 4 abnormal embryonic epiblast morphology 2.35123085644385e-07 4.8739056295034e-06 0.906129156674995 0.914285714285714 5.4 5 4 abnormal chondrocyte physiology 3.5795389941528e-05 0.000437548071152585 0.904898002929513 0.91304347826087 5.4 5 4 abnormal hematopoietic stem cell physiology 3.5795389941528e-05 0.000437548071152585 0.904898002929513 0.91304347826087 5.4 5 4 abnormal tail movements 6.53904968155622e-05 0.000739358458312322 0.900980695557524 0.909090909090909 5.4 5 4 abnormal oogenesis 6.53904968155622e-05 0.000739358458312322 0.900980695557524 0.909090909090909 5.4 5 4 premature suture closure 0.00609786403920246 0.0329748626032959 0.900980695557524 0.909090909090909 5.4 5 4 abnormal sphenoid bone morphology 0.00609786403920246 0.0329748626032959 0.900980695557524 0.909090909090909 5.4 5 4 enlarged cranium 0.00609786403920246 0.0329748626032959 0.900980695557524 0.909090909090909 5.4 5 4 abnormal eye distance/ position 0.00609786403920246 0.0329748626032959 0.900980695557524 0.909090909090909 5.4 5 4 social withdrawal 0.00609786403920246 0.0329748626032959 0.900980695557524 0.909090909090909 5.4 5 4 abnormal food preference 0.00609786403920246 0.0329748626032959 0.900980695557524 0.909090909090909 5.4 5 4 failure of somite differentiation 0.00609786403920246 0.0329748626032959 0.900980695557524 0.909090909090909 5.4 5 4 abnormal hypothalamus secretion 0.00609786403920246 0.0329748626032959 0.900980695557524 0.909090909090909 5.4 5 4 secondary sex reversal 0.00609786403920246 0.0329748626032959 0.900980695557524 0.909090909090909 5.4 5 4 fatigue 0.00609786403920246 0.0329748626032959 0.900980695557524 0.909090909090909 5.4 5 4 pharyngeal arch hypoplasia 0.00609786403920246 0.0329748626032959 0.900980695557524 0.909090909090909 5.4 5 4 abnormal spinal cord ventral horn morphology 0.00609786403920246 0.0329748626032959 0.900980695557524 0.909090909090909 5.4 5 4 abnormal superovulation 0.00609786403920246 0.0329748626032959 0.900980695557524 0.909090909090909 5.4 5 4 aberrant origin of the right subclavian artery 0.00609786403920246 0.0329748626032959 0.900980695557524 0.909090909090909 5.4 5 4 decreased embryonic cilium length 0.00609786403920246 0.0329748626032959 0.900980695557524 0.909090909090909 5.4 5 4 thin hypoglossal nerve 0.00609786403920246 0.0329748626032959 0.900980695557524 0.909090909090909 5.4 5 4 impaired limb coordination 2.3057780590502e-10 8.93594761636812e-09 0.899312212787973 0.907407407407407 5.4 5 4 abnormal lung development 1.76005097053976e-15 1.32670508764171e-13 0.89780076369085 0.905882352941176 5.4 5 4 abnormal erythropoiesis 1.04484094370307e-18 1.23763897498162e-16 0.896690311292964 0.904761904761905 5.4 5 4 abnormal anxiety-related response 0.000118984785190774 0.00124620906594548 0.896690311292964 0.904761904761905 5.4 5 4 abnormal embryonic/fetal subventricular zone morphology 0.000118984785190774 0.00124620906594548 0.896690311292964 0.904761904761905 5.4 5 4 liver hypoplasia 7.56434182843847e-10 2.5600408569035e-08 0.89578273000623 0.903846153846154 5.4 5 4 abnormal mitochondrial ATP synthesis coupled electron transport 2.5789233288772e-06 4.22044196090923e-05 0.895167916876508 0.903225806451613 5.4 5 4 palatal shelves fail to meet at midline 5.85838790320676e-08 1.38787999135494e-06 0.894388153882713 0.902439024390244 5.4 5 4 abnormal cued conditioning behavior 1.36616339900969e-09 4.47148875662711e-08 0.893914180298249 0.901960784313726 5.4 5 4 reduced long term potentiation 1.50543866618675e-19 1.9709361484945e-17 0.893740672111079 0.901785714285714 5.4 5 4 enhanced paired-pulse facilitation 4.65893557796107e-06 7.2658948276979e-05 0.891970888601949 0.9 5.4 5 4 abnormal synaptic transmission 4.65893557796107e-06 7.2658948276979e-05 0.891970888601949 0.9 5.4 5 4 abnormal brain vasculature morphology 4.65893557796107e-06 7.2658948276979e-05 0.891970888601949 0.9 5.4 5 4 abnormal basioccipital bone morphology 0.000215574612332264 0.00207845677587793 0.891970888601949 0.9 5.4 5 4 abnormal circulating enzyme level 0.000215574612332264 0.00207845677587793 0.891970888601949 0.9 5.4 5 4 anencephaly 0.000215574612332264 0.00207845677587793 0.891970888601949 0.9 5.4 5 4 jaundice 0.011132918507352 0.0528500749624308 0.891970888601949 0.9 5.4 5 4 absent trophoblast giant cells 0.011132918507352 0.0528500749624308 0.891970888601949 0.9 5.4 5 4 abnormal PNS synaptic transmission 0.011132918507352 0.0528500749624308 0.891970888601949 0.9 5.4 5 4 impaired basement membrane formation 0.011132918507352 0.0528500749624308 0.891970888601949 0.9 5.4 5 4 abnormal tibialis anterior morphology 0.011132918507352 0.0528500749624308 0.891970888601949 0.9 5.4 5 4 bifid ureter 0.011132918507352 0.0528500749624308 0.891970888601949 0.9 5.4 5 4 absent seminal vesicle 0.011132918507352 0.0528500749624308 0.891970888601949 0.9 5.4 5 4 increased atrioventricular cushion size 0.011132918507352 0.0528500749624308 0.891970888601949 0.9 5.4 5 4 increased heart rate variability 0.011132918507352 0.0528500749624308 0.891970888601949 0.9 5.4 5 4 abnormal cochlear inner hair cell physiology 0.011132918507352 0.0528500749624308 0.891970888601949 0.9 5.4 5 4 decreased thyroxine level 0.011132918507352 0.0528500749624308 0.891970888601949 0.9 5.4 5 4 ventricular premature beat 0.011132918507352 0.0528500749624308 0.891970888601949 0.9 5.4 5 4 decreased transitional stage T2 B cell number 0.011132918507352 0.0528500749624308 0.891970888601949 0.9 5.4 5 4 abnormal hippocampus neuron morphology 0.011132918507352 0.0528500749624308 0.891970888601949 0.9 5.4 5 4 abnormal cerebellar granule cell migration 0.011132918507352 0.0528500749624308 0.891970888601949 0.9 5.4 5 4 common ventricle 0.011132918507352 0.0528500749624308 0.891970888601949 0.9 5.4 5 4 abnormal left subclavian artery morphology 0.011132918507352 0.0528500749624308 0.891970888601949 0.9 5.4 5 4 thick aortic valve cusps 0.011132918507352 0.0528500749624308 0.891970888601949 0.9 5.4 5 4 sinus bradycardia 0.011132918507352 0.0528500749624308 0.891970888601949 0.9 5.4 5 4 fusion of atlas and odontoid process 0.011132918507352 0.0528500749624308 0.891970888601949 0.9 5.4 5 4 decreased trabecular bone connectivity density 0.011132918507352 0.0528500749624308 0.891970888601949 0.9 5.4 5 4 increased compact bone area 0.011132918507352 0.0528500749624308 0.891970888601949 0.9 5.4 5 4 decreased macrophage cytokine production 0.011132918507352 0.0528500749624308 0.891970888601949 0.9 5.4 5 4 abnormal CNS synaptic transmission 3.59370520375357e-17 3.80397518907957e-15 0.890969798940218 0.898989898989899 5.4 5 4 abnormal inhibitory postsynaptic currents 4.5132466123084e-12 2.20131391139552e-10 0.889055951057498 0.897058823529412 5.4 5 4 short sternum 8.38865234573698e-06 0.000125325962222347 0.888553375618799 0.896551724137931 5.4 5 4 abnormal spatial learning 6.47873274583688e-27 1.79064974502992e-24 0.887714722126002 0.895705521472393 5.4 5 4 abnormal long term depression 0.000388731497912698 0.0034596407909046 0.886754684575037 0.894736842105263 5.4 5 4 increased malignant tumor incidence 0.000388731497912698 0.0034596407909046 0.886754684575037 0.894736842105263 5.4 5 4 abnormal nasal septum morphology 0.000388731497912698 0.0034596407909046 0.886754684575037 0.894736842105263 5.4 5 4 absent amnion 0.000388731497912698 0.0034596407909046 0.886754684575037 0.894736842105263 5.4 5 4 increased cellular sensitivity to gamma-irradiation 1.42340382016795e-08 3.82780216504624e-07 0.885644853931013 0.893617021276596 5.4 5 4 abnormal cell nucleus morphology 1.42340382016795e-08 3.82780216504624e-07 0.885644853931013 0.893617021276596 5.4 5 4 enhanced long term potentiation 6.0341466294836e-10 2.08471385289451e-08 0.884891754565425 0.892857142857143 5.4 5 4 premature aging 1.50506724559932e-05 0.000200742883293744 0.884891754565425 0.892857142857143 5.4 5 4 increased bone resorption 1.50506724559932e-05 0.000200742883293744 0.884891754565425 0.892857142857143 5.4 5 4 hypoxia 1.50506724559932e-05 0.000200742883293744 0.884891754565425 0.892857142857143 5.4 5 4 abnormal brainstem morphology 1.50506724559932e-05 0.000200742883293744 0.884891754565425 0.892857142857143 5.4 5 4 prolonged QRS complex duration 1.50506724559932e-05 0.000200742883293744 0.884891754565425 0.892857142857143 5.4 5 4 subcutaneous edema 1.50506724559932e-05 0.000200742883293744 0.884891754565425 0.892857142857143 5.4 5 4 decreased width of hypertrophic chondrocyte zone 6.10552171467163e-07 1.14886292042455e-05 0.88393511483076 0.891891891891892 5.4 5 4 gliosis 8.20890342602238e-11 3.52584084157415e-09 0.880958902322912 0.888888888888889 5.4 5 4 irregular heartbeat 4.53138557330001e-08 1.09968991352037e-06 0.880958902322912 0.888888888888889 5.4 5 4 abnormal pharyngeal arch morphology 1.08922850902773e-06 1.94924886058019e-05 0.880958902322912 0.888888888888889 5.4 5 4 decreased cellular sensitivity to gamma-irradiation 0.000697326045820602 0.00569654692603858 0.880958902322912 0.888888888888889 5.4 5 4 abnormal body wall morphology 0.000697326045820602 0.00569654692603858 0.880958902322912 0.888888888888889 5.4 5 4 darkened coat color 0.000697326045820602 0.00569654692603858 0.880958902322912 0.888888888888889 5.4 5 4 atrioventricular block 0.000697326045820602 0.00569654692603858 0.880958902322912 0.888888888888889 5.4 5 4 abnormal metanephric mesenchyme morphology 0.000697326045820602 0.00569654692603858 0.880958902322912 0.888888888888889 5.4 5 4 abnormal hypoglossal nerve topology 0.000697326045820602 0.00569654692603858 0.880958902322912 0.888888888888889 5.4 5 4 abnormal kindling response 0.0201571670986346 0.0816627901593704 0.880958902322912 0.888888888888889 5.4 5 4 abnormal ion homeostasis 0.0201571670986346 0.0816627901593704 0.880958902322912 0.888888888888889 5.4 5 4 abnormal germ cell morphology 0.0201571670986346 0.0816627901593704 0.880958902322912 0.888888888888889 5.4 5 4 abnormal vomeronasal organ morphology 0.0201571670986346 0.0816627901593704 0.880958902322912 0.888888888888889 5.4 5 4 pancreas cysts 0.0201571670986346 0.0816627901593704 0.880958902322912 0.888888888888889 5.4 5 4 premature bone ossification 0.0201571670986346 0.0816627901593704 0.880958902322912 0.888888888888889 5.4 5 4 abnormal proprioceptive neuron morphology 0.0201571670986346 0.0816627901593704 0.880958902322912 0.888888888888889 5.4 5 4 positive geotaxis 0.0201571670986346 0.0816627901593704 0.880958902322912 0.888888888888889 5.4 5 4 abnormal liver vasculature morphology 0.0201571670986346 0.0816627901593704 0.880958902322912 0.888888888888889 5.4 5 4 decreased transitional stage T1 B cell number 0.0201571670986346 0.0816627901593704 0.880958902322912 0.888888888888889 5.4 5 4 abnormal hippocampus granule cell morphology 0.0201571670986346 0.0816627901593704 0.880958902322912 0.888888888888889 5.4 5 4 abnormal telomere morphology 0.0201571670986346 0.0816627901593704 0.880958902322912 0.888888888888889 5.4 5 4 retropulsion 0.0201571670986346 0.0816627901593704 0.880958902322912 0.888888888888889 5.4 5 4 iris coloboma 0.0201571670986346 0.0816627901593704 0.880958902322912 0.888888888888889 5.4 5 4 abnormal pulmonary alveolar system morphology 0.0201571670986346 0.0816627901593704 0.880958902322912 0.888888888888889 5.4 5 4 abnormal oxidative phosphorylation 0.0201571670986346 0.0816627901593704 0.880958902322912 0.888888888888889 5.4 5 4 abnormal ductus venosus valve topology 0.0201571670986346 0.0816627901593704 0.880958902322912 0.888888888888889 5.4 5 4 symmetric azygos veins 0.0201571670986346 0.0816627901593704 0.880958902322912 0.888888888888889 5.4 5 4 increased endoplasmic reticulum stress 0.0201571670986346 0.0816627901593704 0.880958902322912 0.888888888888889 5.4 5 4 pericardial effusion 1.4583950833606e-10 5.89879312172274e-09 0.879182775503713 0.887096774193548 5.4 5 4 abnormal liver development 1.93705633036938e-06 3.27599796919848e-05 0.877812620528902 0.885714285714286 5.4 5 4 distended pericardium 6.04075405628115e-09 1.77826931538454e-07 0.876723522984821 0.884615384615385 5.4 5 4 abnormal brain wave pattern 6.04075405628115e-09 1.77826931538454e-07 0.876723522984821 0.884615384615385 5.4 5 4 abnormal nasal bone morphology 4.78858801010928e-05 0.000571300368112557 0.876723522984821 0.884615384615385 5.4 5 4 increased susceptibility to otitis media 4.78858801010928e-05 0.000571300368112557 0.876723522984821 0.884615384615385 5.4 5 4 abnormal kidney development 4.57591210887899e-10 1.63778149220669e-08 0.875452909183394 0.883333333333333 5.4 5 4 impaired balance 3.9788931811678e-16 3.35508365700166e-14 0.874481263335244 0.882352941176471 5.4 5 4 small lung 1.06842596347395e-08 3.00571197567361e-07 0.874481263335244 0.882352941176471 5.4 5 4 hyperlipidemia 0.0012436826348206 0.00917918985243888 0.874481263335244 0.882352941176471 5.4 5 4 abnormal heart rate 0.0012436826348206 0.00917918985243888 0.874481263335244 0.882352941176471 5.4 5 4 abnormal touch/ nociception 0.0012436826348206 0.00917918985243888 0.874481263335244 0.882352941176471 5.4 5 4 abnormal embryonic-extraembryonic boundary morphology 0.0012436826348206 0.00917918985243888 0.874481263335244 0.882352941176471 5.4 5 4 abnormal reproductive system morphology 2.52368967191329e-07 5.16681321718873e-06 0.873093197837886 0.880952380952381 5.4 5 4 abnormal cochlear outer hair cell morphology 8.48668087846365e-05 0.000936169343023429 0.872149313299683 0.88 5.4 5 4 embryonic lethality, complete penetrance 2.63384990061744e-46 1.45593369506353e-43 0.869912395710713 0.877742946708464 5.4 5 4 vertebral transformation 5.82294144231339e-08 1.3860829509813e-06 0.867193919474117 0.875 5.4 5 4 abnormal body weight 0.000149695070009895 0.00150147776874844 0.867193919474117 0.875 5.4 5 4 ocular hypertelorism 0.000149695070009895 0.00150147776874844 0.867193919474117 0.875 5.4 5 4 abnormal nursing 0.000149695070009895 0.00150147776874844 0.867193919474117 0.875 5.4 5 4 increased stereotypic behavior 0.000149695070009895 0.00150147776874844 0.867193919474117 0.875 5.4 5 4 abnormal truncus arteriosus septation 0.000149695070009895 0.00150147776874844 0.867193919474117 0.875 5.4 5 4 abnormal long term potentiation 1.06696481057053e-05 0.000155209062356386 0.867193919474117 0.875 5.4 5 4 abnormal heart atrium morphology 1.06696481057053e-05 0.000155209062356386 0.867193919474117 0.875 5.4 5 4 abnormal depression-related behavior 1.06696481057053e-05 0.000155209062356386 0.867193919474117 0.875 5.4 5 4 abnormal tympanic ring morphology 0.00220384853537741 0.0143886436528906 0.867193919474117 0.875 5.4 5 4 abnormal mouth morphology 0.00220384853537741 0.0143886436528906 0.867193919474117 0.875 5.4 5 4 disorganized yolk sac vascular plexus 0.00220384853537741 0.0143886436528906 0.867193919474117 0.875 5.4 5 4 increased intestinal adenocarcinoma incidence 0.00220384853537741 0.0143886436528906 0.867193919474117 0.875 5.4 5 4 increased cochlear outer hair cell number 0.00220384853537741 0.0143886436528906 0.867193919474117 0.875 5.4 5 4 dystonia 0.00220384853537741 0.0143886436528906 0.867193919474117 0.875 5.4 5 4 decreased liver cholesterol level 0.00220384853537741 0.0143886436528906 0.867193919474117 0.875 5.4 5 4 abnormal exoccipital bone morphology 0.0361310391084127 0.125437487483847 0.867193919474117 0.875 5.4 5 4 abnormal bone marrow development 0.0361310391084127 0.125437487483847 0.867193919474117 0.875 5.4 5 4 abnormal cecum morphology 0.0361310391084127 0.125437487483847 0.867193919474117 0.875 5.4 5 4 increased sensitivity to skin irradiation 0.0361310391084127 0.125437487483847 0.867193919474117 0.875 5.4 5 4 dry eyes 0.0361310391084127 0.125437487483847 0.867193919474117 0.875 5.4 5 4 absent eyelids 0.0361310391084127 0.125437487483847 0.867193919474117 0.875 5.4 5 4 preneoplasia 0.0361310391084127 0.125437487483847 0.867193919474117 0.875 5.4 5 4 abnormal hepatobiliary system morphology 0.0361310391084127 0.125437487483847 0.867193919474117 0.875 5.4 5 4 abnormal secondary sex determination 0.0361310391084127 0.125437487483847 0.867193919474117 0.875 5.4 5 4 abnormal pulmonary circulation 0.0361310391084127 0.125437487483847 0.867193919474117 0.875 5.4 5 4 short ureter 0.0361310391084127 0.125437487483847 0.867193919474117 0.875 5.4 5 4 altered response to CNS ischemic injury 0.0361310391084127 0.125437487483847 0.867193919474117 0.875 5.4 5 4 decreased corneal stroma thickness 0.0361310391084127 0.125437487483847 0.867193919474117 0.875 5.4 5 4 hypospadia 0.0361310391084127 0.125437487483847 0.867193919474117 0.875 5.4 5 4 absent tympanic ring 0.0361310391084127 0.125437487483847 0.867193919474117 0.875 5.4 5 4 liver cysts 0.0361310391084127 0.125437487483847 0.867193919474117 0.875 5.4 5 4 abnormal eyelid aperture 0.0361310391084127 0.125437487483847 0.867193919474117 0.875 5.4 5 4 elevated level of mitotic sister chromatid exchange 0.0361310391084127 0.125437487483847 0.867193919474117 0.875 5.4 5 4 binucleate 0.0361310391084127 0.125437487483847 0.867193919474117 0.875 5.4 5 4 increased left ventricle systolic pressure 0.0361310391084127 0.125437487483847 0.867193919474117 0.875 5.4 5 4 abnormal extraembryonic tissue physiology 0.0361310391084127 0.125437487483847 0.867193919474117 0.875 5.4 5 4 absent interparietal bone 0.0361310391084127 0.125437487483847 0.867193919474117 0.875 5.4 5 4 absent cochlear microphonics 0.0361310391084127 0.125437487483847 0.867193919474117 0.875 5.4 5 4 abnormal kidney epithelium morphology 0.0361310391084127 0.125437487483847 0.867193919474117 0.875 5.4 5 4 accumulation of giant lysosomes in kidney/renal tubule cells 0.0361310391084127 0.125437487483847 0.867193919474117 0.875 5.4 5 4 abnormal somite size 0.0361310391084127 0.125437487483847 0.867193919474117 0.875 5.4 5 4 abnormal vertebral body development 0.0361310391084127 0.125437487483847 0.867193919474117 0.875 5.4 5 4 abnormal olfactory tract morphology 0.0361310391084127 0.125437487483847 0.867193919474117 0.875 5.4 5 4 Sertoli cell hypoplasia 0.0361310391084127 0.125437487483847 0.867193919474117 0.875 5.4 5 4 abnormal epidermal lamellar body morphology 0.0361310391084127 0.125437487483847 0.867193919474117 0.875 5.4 5 4 abnormal mitotic spindle assembly checkpoint 0.0361310391084127 0.125437487483847 0.867193919474117 0.875 5.4 5 4 abnormal base-excision repair 0.0361310391084127 0.125437487483847 0.867193919474117 0.875 5.4 5 4 abnormal olfactory bulb mitral cell layer morphology 0.0361310391084127 0.125437487483847 0.867193919474117 0.875 5.4 5 4 decreased hippocampus pyramidal cell number 0.0361310391084127 0.125437487483847 0.867193919474117 0.875 5.4 5 4 heart right ventricle hypoplasia 0.0361310391084127 0.125437487483847 0.867193919474117 0.875 5.4 5 4 sinoatrial block 0.0361310391084127 0.125437487483847 0.867193919474117 0.875 5.4 5 4 delayed suture closure 0.0361310391084127 0.125437487483847 0.867193919474117 0.875 5.4 5 4 lung situs inversus 0.0361310391084127 0.125437487483847 0.867193919474117 0.875 5.4 5 4 impaired neuron differentiation 0.0361310391084127 0.125437487483847 0.867193919474117 0.875 5.4 5 4 decreased cranium length 0.0361310391084127 0.125437487483847 0.867193919474117 0.875 5.4 5 4 abnormal heart echocardiography feature 0.0361310391084127 0.125437487483847 0.867193919474117 0.875 5.4 5 4 prolonged PQ interval 0.0361310391084127 0.125437487483847 0.867193919474117 0.875 5.4 5 4 increased cornea thickness 0.0361310391084127 0.125437487483847 0.867193919474117 0.875 5.4 5 4 increased testis apoptosis 0.0361310391084127 0.125437487483847 0.867193919474117 0.875 5.4 5 4 absent hypoglossal canal 0.0361310391084127 0.125437487483847 0.867193919474117 0.875 5.4 5 4 decreased white adipose tissue mass 0.0361310391084127 0.125437487483847 0.867193919474117 0.875 5.4 5 4 decreased basal metabolism 0.0361310391084127 0.125437487483847 0.867193919474117 0.875 5.4 5 4 small liver 6.00052468354717e-12 2.89831167967448e-10 0.864017384970548 0.871794871794872 5.4 5 4 inner cell mass degeneration 1.86990182592773e-05 0.000246757601697359 0.863197634130918 0.870967741935484 5.4 5 4 abnormal maxilla morphology 1.34099791596627e-08 3.64560908848755e-07 0.862605591857852 0.87037037037037 5.4 5 4 abnormal neuronal precursor proliferation 1.34099791596627e-08 3.64560908848755e-07 0.862605591857852 0.87037037037037 5.4 5 4 abnormal locomotor behavior 1.08875514885284e-13 6.15517825629875e-12 0.861807621837631 0.869565217391304 5.4 5 4 embryonic lethality between implantation and placentation, complete penetrance 1.77884633068573e-07 3.81455193756962e-06 0.861807621837631 0.869565217391304 5.4 5 4 abnormal cochlear ganglion morphology 0.000262691209309122 0.00247516811801683 0.861807621837631 0.869565217391304 5.4 5 4 abnormal cell cycle 8.91495308245167e-17 8.36828143116926e-15 0.861807621837631 0.869565217391304 5.4 5 4 abnormal vitelline vasculature morphology 8.91495308245167e-17 8.36828143116926e-15 0.861807621837631 0.869565217391304 5.4 5 4 abnormal neuron morphology 1.47030616799243e-14 9.75303091434977e-13 0.860937109088301 0.868686868686869 5.4 5 4 abnormal myocardial trabeculae morphology 3.09527360371618e-07 6.14323445442476e-06 0.858934929764839 0.866666666666667 5.4 5 4 abnormal heart tube morphology 3.26318113362806e-05 0.000403838958701482 0.858934929764839 0.866666666666667 5.4 5 4 abnormal response to new environment 3.26318113362806e-05 0.000403838958701482 0.858934929764839 0.866666666666667 5.4 5 4 macrocytosis 0.00387713148319358 0.0232119232861295 0.858934929764839 0.866666666666667 5.4 5 4 abnormal prostate gland morphology 0.00387713148319358 0.0232119232861295 0.858934929764839 0.866666666666667 5.4 5 4 abnormal seizure response to electrical stimulation 0.00387713148319358 0.0232119232861295 0.858934929764839 0.866666666666667 5.4 5 4 absent egg cylinders 0.00387713148319358 0.0232119232861295 0.858934929764839 0.866666666666667 5.4 5 4 abnormal lymph node B cell domain morphology 0.00387713148319358 0.0232119232861295 0.858934929764839 0.866666666666667 5.4 5 4 delayed intramembranous bone ossification 0.00387713148319358 0.0232119232861295 0.858934929764839 0.866666666666667 5.4 5 4 abnormal placenta size 0.00387713148319358 0.0232119232861295 0.858934929764839 0.866666666666667 5.4 5 4 abnormal rostral migratory stream morphology 0.00387713148319358 0.0232119232861295 0.858934929764839 0.866666666666667 5.4 5 4 decreased thymocyte apoptosis 0.00387713148319358 0.0232119232861295 0.858934929764839 0.866666666666667 5.4 5 4 abnormal secondary palate development 0.00387713148319358 0.0232119232861295 0.858934929764839 0.866666666666667 5.4 5 4 abnormal branching involved in lung morphogenesis 0.00387713148319358 0.0232119232861295 0.858934929764839 0.866666666666667 5.4 5 4 kinked neural tube 4.05353669248284e-08 9.93416012073997e-07 0.857664315963412 0.865384615384615 5.4 5 4 preweaning lethality, complete penetrance 2.42863250551327e-98 1.20824467149285e-94 0.857149202260131 0.864864864864865 5.4 5 4 malocclusion 4.15275706941532e-06 6.60062824931029e-05 0.857149202260131 0.864864864864865 5.4 5 4 abnormal vocalization 4.15275706941532e-06 6.60062824931029e-05 0.857149202260131 0.864864864864865 5.4 5 4 abnormal breathing pattern 4.15275706941532e-06 6.60062824931029e-05 0.857149202260131 0.864864864864865 5.4 5 4 increased susceptibility to pharmacologically induced seizures 7.66666130968719e-14 4.46423085494732e-12 0.85687018233752 0.864583333333333 5.4 5 4 abnormal vascular branching morphogenesis 0.000458415278233782 0.00400811249422331 0.855931660779648 0.863636363636364 5.4 5 4 abnormal channel response 0.000458415278233782 0.00400811249422331 0.855931660779648 0.863636363636364 5.4 5 4 abnormal limb posture 0.000458415278233782 0.00400811249422331 0.855931660779648 0.863636363636364 5.4 5 4 abnormal cerebral cortex pyramidal cell morphology 0.000458415278233782 0.00400811249422331 0.855931660779648 0.863636363636364 5.4 5 4 abnormal fertility/fecundity 9.46749548638645e-11 3.97751236516608e-09 0.855314550714197 0.863013698630137 5.4 5 4 abnormal response to novel object 7.01844689578649e-08 1.64701760879895e-06 0.855048346372238 0.862745098039216 5.4 5 4 abnormal axon morphology 4.16118450854849e-15 2.95741327571839e-13 0.853428936625321 0.861111111111111 5.4 5 4 abnormal vasculogenesis 9.28214623071008e-07 1.69152664827043e-05 0.852788704864912 0.86046511627907 5.4 5 4 increased B cell derived lymphoma incidence 1.21167604089029e-07 2.69111084974519e-06 0.852327737997418 0.86 5.4 5 4 seizures 9.68164068701412e-16 7.64542260601512e-14 0.85197999106229 0.859649122807018 5.4 5 4 decreased brain weight 1.59512734419891e-08 4.22114815818594e-07 0.85197999106229 0.859649122807018 5.4 5 4 increased hepatocellular carcinoma incidence 1.59512734419891e-08 4.22114815818594e-07 0.85197999106229 0.859649122807018 5.4 5 4 pallor 4.42008909806305e-23 7.32998108762123e-21 0.849496084382808 0.857142857142857 5.4 5 4 embryonic lethality between implantation and somite formation, complete penetrance 9.33973369603268e-32 2.90407344611016e-29 0.849496084382808 0.857142857142857 5.4 5 4 rib bifurcation 9.80028859482808e-05 0.00105762333534208 0.849496084382808 0.857142857142857 5.4 5 4 myoclonus 9.80028859482808e-05 0.00105762333534208 0.849496084382808 0.857142857142857 5.4 5 4 abnormal ovulation 9.80028859482808e-05 0.00105762333534208 0.849496084382808 0.857142857142857 5.4 5 4 straub tail 9.80028859482808e-05 0.00105762333534208 0.849496084382808 0.857142857142857 5.4 5 4 abnormal renal tubule epithelium morphology 9.80028859482808e-05 0.00105762333534208 0.849496084382808 0.857142857142857 5.4 5 4 abnormal blood flow velocity 0.00676530866008962 0.0355035976623901 0.849496084382808 0.857142857142857 5.4 5 4 increased aggression towards males 0.00676530866008962 0.0355035976623901 0.849496084382808 0.857142857142857 5.4 5 4 abnormal adrenal gland secretion 0.00676530866008962 0.0355035976623901 0.849496084382808 0.857142857142857 5.4 5 4 increased hemangioma incidence 0.00676530866008962 0.0355035976623901 0.849496084382808 0.857142857142857 5.4 5 4 abnormal kidney medulla morphology 0.00676530866008962 0.0355035976623901 0.849496084382808 0.857142857142857 5.4 5 4 failure of zygotic cell division 0.00676530866008962 0.0355035976623901 0.849496084382808 0.857142857142857 5.4 5 4 lysosomal protein accumulation 0.00676530866008962 0.0355035976623901 0.849496084382808 0.857142857142857 5.4 5 4 abnormal viscerocranium morphology 0.00676530866008962 0.0355035976623901 0.849496084382808 0.857142857142857 5.4 5 4 spina bifida occulta 0.00676530866008962 0.0355035976623901 0.849496084382808 0.857142857142857 5.4 5 4 multiple persisting craniopharyngeal ducts 0.00676530866008962 0.0355035976623901 0.849496084382808 0.857142857142857 5.4 5 4 cochlear degeneration 0.063963860427 0.186639416788461 0.849496084382808 0.857142857142857 5.4 5 4 polyphalangy 0.063963860427 0.186639416788461 0.849496084382808 0.857142857142857 5.4 5 4 abnormal foot pad morphology 0.063963860427 0.186639416788461 0.849496084382808 0.857142857142857 5.4 5 4 mammary gland hyperplasia 0.063963860427 0.186639416788461 0.849496084382808 0.857142857142857 5.4 5 4 abnormal oculomotor nerve morphology 0.063963860427 0.186639416788461 0.849496084382808 0.857142857142857 5.4 5 4 decreased Schwann cell number 0.063963860427 0.186639416788461 0.849496084382808 0.857142857142857 5.4 5 4 retina hyperplasia 0.063963860427 0.186639416788461 0.849496084382808 0.857142857142857 5.4 5 4 excessive tearing 0.063963860427 0.186639416788461 0.849496084382808 0.857142857142857 5.4 5 4 limp posture 0.063963860427 0.186639416788461 0.849496084382808 0.857142857142857 5.4 5 4 abnormal circulating free fatty acids level 0.063963860427 0.186639416788461 0.849496084382808 0.857142857142857 5.4 5 4 abnormal gastrulation movements 0.063963860427 0.186639416788461 0.849496084382808 0.857142857142857 5.4 5 4 abnormal brain ventricular system morphology 0.063963860427 0.186639416788461 0.849496084382808 0.857142857142857 5.4 5 4 abnormal melanocyte morphology 0.063963860427 0.186639416788461 0.849496084382808 0.857142857142857 5.4 5 4 decreased cholesterol efflux 0.063963860427 0.186639416788461 0.849496084382808 0.857142857142857 5.4 5 4 decreased cardiomyocyte apoptosis 0.063963860427 0.186639416788461 0.849496084382808 0.857142857142857 5.4 5 4 skeletal muscle interstitial fibrosis 0.063963860427 0.186639416788461 0.849496084382808 0.857142857142857 5.4 5 4 increased ectoderm apoptosis 0.063963860427 0.186639416788461 0.849496084382808 0.857142857142857 5.4 5 4 renal necrosis 0.063963860427 0.186639416788461 0.849496084382808 0.857142857142857 5.4 5 4 abnormal optic tract morphology 0.063963860427 0.186639416788461 0.849496084382808 0.857142857142857 5.4 5 4 absent endocochlear potential 0.063963860427 0.186639416788461 0.849496084382808 0.857142857142857 5.4 5 4 abnormal cochlear hair cell physiology 0.063963860427 0.186639416788461 0.849496084382808 0.857142857142857 5.4 5 4 abnormal talus morphology 0.063963860427 0.186639416788461 0.849496084382808 0.857142857142857 5.4 5 4 increased thyroid-stimulating hormone level 0.063963860427 0.186639416788461 0.849496084382808 0.857142857142857 5.4 5 4 atherosclerotic lesions 0.063963860427 0.186639416788461 0.849496084382808 0.857142857142857 5.4 5 4 abnormal thyroid hormone level 0.063963860427 0.186639416788461 0.849496084382808 0.857142857142857 5.4 5 4 abnormal uterus physiology 0.063963860427 0.186639416788461 0.849496084382808 0.857142857142857 5.4 5 4 enhanced behavioral response to alcohol 0.063963860427 0.186639416788461 0.849496084382808 0.857142857142857 5.4 5 4 decreased behavioral withdrawal response 0.063963860427 0.186639416788461 0.849496084382808 0.857142857142857 5.4 5 4 decreased DN4 thymocyte number 0.063963860427 0.186639416788461 0.849496084382808 0.857142857142857 5.4 5 4 increased oligodendrocyte number 0.063963860427 0.186639416788461 0.849496084382808 0.857142857142857 5.4 5 4 decreased brain cholesterol level 0.063963860427 0.186639416788461 0.849496084382808 0.857142857142857 5.4 5 4 abnormal retina inner limiting membrane morphology 0.063963860427 0.186639416788461 0.849496084382808 0.857142857142857 5.4 5 4 coronary fistula 0.063963860427 0.186639416788461 0.849496084382808 0.857142857142857 5.4 5 4 abnormal T wave 0.063963860427 0.186639416788461 0.849496084382808 0.857142857142857 5.4 5 4 long stride length 0.063963860427 0.186639416788461 0.849496084382808 0.857142857142857 5.4 5 4 heart block 0.063963860427 0.186639416788461 0.849496084382808 0.857142857142857 5.4 5 4 abnormal conotruncal ridge morphology 0.063963860427 0.186639416788461 0.849496084382808 0.857142857142857 5.4 5 4 abnormal aortic valve cusp morphology 0.063963860427 0.186639416788461 0.849496084382808 0.857142857142857 5.4 5 4 thick pulmonary valve 0.063963860427 0.186639416788461 0.849496084382808 0.857142857142857 5.4 5 4 altered tumor pathology 0.063963860427 0.186639416788461 0.849496084382808 0.857142857142857 5.4 5 4 small lung saccule 0.063963860427 0.186639416788461 0.849496084382808 0.857142857142857 5.4 5 4 dilated pulmonary alveolar ducts 0.063963860427 0.186639416788461 0.849496084382808 0.857142857142857 5.4 5 4 increased compact bone volume 0.063963860427 0.186639416788461 0.849496084382808 0.857142857142857 5.4 5 4 impaired branching involved in bronchus morphogenesis 0.063963860427 0.186639416788461 0.849496084382808 0.857142857142857 5.4 5 4 embryonic lethality at implantation, incomplete penetrance 0.063963860427 0.186639416788461 0.849496084382808 0.857142857142857 5.4 5 4 decreased areal bone mineral density 0.063963860427 0.186639416788461 0.849496084382808 0.857142857142857 5.4 5 4 ductus venosus stenosis 0.063963860427 0.186639416788461 0.849496084382808 0.857142857142857 5.4 5 4 fragmented Meckel's cartilage 0.063963860427 0.186639416788461 0.849496084382808 0.857142857142857 5.4 5 4 embryo tumor 0.063963860427 0.186639416788461 0.849496084382808 0.857142857142857 5.4 5 4 spina bifida 1.59921066302214e-06 2.78184372326404e-05 0.849496084382808 0.857142857142857 5.4 5 4 increased incidence of induced tumors 0.000795113575181203 0.00636987123434217 0.849496084382808 0.857142857142857 5.4 5 4 left pulmonary isomerism 0.000795113575181203 0.00636987123434217 0.849496084382808 0.857142857142857 5.4 5 4 absent segment of posterior cerebral artery 0.000795113575181203 0.00636987123434217 0.849496084382808 0.857142857142857 5.4 5 4 decreased vocalization 0.000795113575181203 0.00636987123434217 0.849496084382808 0.857142857142857 5.4 5 4 increased muscle cell glucose uptake 0.000795113575181203 0.00636987123434217 0.849496084382808 0.857142857142857 5.4 5 4 embryonic lethality between somite formation and embryo turning, complete penetrance 4.83511073477787e-10 1.7060053833702e-08 0.849496084382808 0.857142857142857 5.4 5 4 increased carcinoma incidence 1.2410870396231e-05 0.000175409318810368 0.849496084382808 0.857142857142857 5.4 5 4 abnormal midbrain development 1.2410870396231e-05 0.000175409318810368 0.849496084382808 0.857142857142857 5.4 5 4 abnormal hippocampus pyramidal cell morphology 1.2410870396231e-05 0.000175409318810368 0.849496084382808 0.857142857142857 5.4 5 4 abnormal learning/memory/conditioning 4.70572853162329e-08 1.13645628372941e-06 0.846921853824072 0.854545454545454 5.4 5 4 overriding aortic valve 3.57835341768896e-07 7.00878277677267e-06 0.846546445200923 0.854166666666667 5.4 5 4 thymus atrophy 3.57835341768896e-07 7.00878277677267e-06 0.846546445200923 0.854166666666667 5.4 5 4 decreased cell proliferation 7.01593111113486e-24 1.2927502695517e-21 0.846434837231879 0.854054054054054 5.4 5 4 decreased rib number 3.41328480382689e-12 1.6812962276276e-10 0.846314451107966 0.853932584269663 5.4 5 4 preweaning lethality, incomplete penetrance 6.21694389368114e-51 3.86616198388296e-48 0.845688237223798 0.853300733496333 5.4 5 4 abnormal nervous system development 2.13208653692692e-05 0.000276948577577322 0.845331887890736 0.852941176470588 5.4 5 4 abnormal maternal nurturing 1.06547521810321e-08 3.00571197567361e-07 0.844854029276891 0.852459016393443 5.4 5 4 axon degeneration 8.04788503651139e-08 1.86224316542531e-06 0.844252281392791 0.851851851851852 5.4 5 4 abnormal palate morphology 0.000168549005834607 0.00167371517769894 0.844252281392791 0.851851851851852 5.4 5 4 limb grasping 3.49317603241168e-23 5.9926037107752e-21 0.844050596662406 0.851648351648352 5.4 5 4 pale liver 3.23370525085233e-10 1.20057340470077e-08 0.843756245974816 0.851351351351351 5.4 5 4 pulmonary hypoplasia 6.11957133492476e-07 1.14886292042455e-05 0.843471289458107 0.851063829787234 5.4 5 4 absent mesoderm 1.81745469918526e-08 4.75886164655087e-07 0.842416950346285 0.85 5.4 5 4 abnormal vascular regression 0.00136995384953516 0.00986327120323794 0.842416950346285 0.85 5.4 5 4 abnormal dopamine level 0.00136995384953516 0.00986327120323794 0.842416950346285 0.85 5.4 5 4 decreased myocardial infarction size 0.00136995384953516 0.00986327120323794 0.842416950346285 0.85 5.4 5 4 abnormal hyoid bone morphology 0.00136995384953516 0.00986327120323794 0.842416950346285 0.85 5.4 5 4 spleen atrophy 0.00136995384953516 0.00986327120323794 0.842416950346285 0.85 5.4 5 4 abnormal heart right ventricle morphology 0.00136995384953516 0.00986327120323794 0.842416950346285 0.85 5.4 5 4 abnormal response to tactile stimuli 0.00136995384953516 0.00986327120323794 0.842416950346285 0.85 5.4 5 4 abnormal sperm mitochondrial sheath morphology 0.00136995384953516 0.00986327120323794 0.842416950346285 0.85 5.4 5 4 increased skin tumor incidence 0.00136995384953516 0.00986327120323794 0.842416950346285 0.85 5.4 5 4 absent ductus venosus valve 0.00136995384953516 0.00986327120323794 0.842416950346285 0.85 5.4 5 4 abnormal embryo size 9.59099625704564e-15 6.53632964093179e-13 0.841978419919243 0.849557522123894 5.4 5 4 hyperactivity 4.08133933418324e-45 1.69205526563013e-42 0.841481970379197 0.849056603773585 5.4 5 4 enlarged kidney 1.37224947099345e-07 3.00746304766186e-06 0.841481970379197 0.849056603773585 5.4 5 4 single kidney 3.64621873588458e-05 0.000444606328701613 0.840915315853689 0.848484848484849 5.4 5 4 abnormal motor coordination/ balance 5.23264116371896e-13 2.79918169779589e-11 0.840915315853689 0.848484848484849 5.4 5 4 abnormal myelin sheath morphology 1.04296541248859e-06 1.87319600257427e-05 0.840262431291691 0.847826086956522 5.4 5 4 atrial septal defect 1.04296541248859e-06 1.87319600257427e-05 0.840262431291691 0.847826086956522 5.4 5 4 abnormal kidney cortex morphology 0.000288261916544128 0.00265574636075377 0.838605108942003 0.846153846153846 5.4 5 4 increased leukemia incidence 0.000288261916544128 0.00265574636075377 0.838605108942003 0.846153846153846 5.4 5 4 decreased circulating glycerol level 0.000288261916544128 0.00265574636075377 0.838605108942003 0.846153846153846 5.4 5 4 abnormal nerve conduction 0.000288261916544128 0.00265574636075377 0.838605108942003 0.846153846153846 5.4 5 4 absent teeth 0.0116955331641233 0.0547883968846643 0.838605108942003 0.846153846153846 5.4 5 4 absent myocardial trabeculae 0.0116955331641233 0.0547883968846643 0.838605108942003 0.846153846153846 5.4 5 4 absent trabeculae carneae 0.0116955331641233 0.0547883968846643 0.838605108942003 0.846153846153846 5.4 5 4 abnormal lung interstitium morphology 0.0116955331641233 0.0547883968846643 0.838605108942003 0.846153846153846 5.4 5 4 dystrophic cardiac calcinosis 0.0116955331641233 0.0547883968846643 0.838605108942003 0.846153846153846 5.4 5 4 abnormal tail bud morphology 0.0116955331641233 0.0547883968846643 0.838605108942003 0.846153846153846 5.4 5 4 abnormal telomere length 0.0116955331641233 0.0547883968846643 0.838605108942003 0.846153846153846 5.4 5 4 axonal dystrophy 0.0116955331641233 0.0547883968846643 0.838605108942003 0.846153846153846 5.4 5 4 abnormal afterhyperpolarization 0.0116955331641233 0.0547883968846643 0.838605108942003 0.846153846153846 5.4 5 4 increased cochlear inner hair cell number 0.0116955331641233 0.0547883968846643 0.838605108942003 0.846153846153846 5.4 5 4 abnormal vertebral arch development 0.0116955331641233 0.0547883968846643 0.838605108942003 0.846153846153846 5.4 5 4 abnormal aorta tunica media morphology 0.0116955331641233 0.0547883968846643 0.838605108942003 0.846153846153846 5.4 5 4 increased embryonic tissue cell apoptosis 2.13091216761568e-10 8.34747089282521e-09 0.838605108942003 0.846153846153846 5.4 5 4 decreased anxiety-related response 1.46384319067477e-15 1.120403057478e-13 0.837985297331551 0.845528455284553 5.4 5 4 abnormal nervous system electrophysiology 4.8622387175411e-11 2.1406758955546e-09 0.837697527655269 0.845238095238095 5.4 5 4 abnormal lumbar vertebrae morphology 6.20576170885657e-05 0.000726256675328396 0.836222708064327 0.84375 5.4 5 4 abnormal auditory brainstem response waveform shape 6.20576170885657e-05 0.000726256675328396 0.836222708064327 0.84375 5.4 5 4 hydroencephaly 1.81871490860268e-14 1.17507878835043e-12 0.835953393182503 0.843478260869565 5.4 5 4 abnormal neural tube closure 8.22105603261511e-11 3.52584084157415e-09 0.835849560938908 0.843373493975904 5.4 5 4 failure of chorioallantoic fusion 3.95201955419041e-07 7.68019425081925e-06 0.835615429409233 0.843137254901961 5.4 5 4 abnormal craniofacial bone morphology 8.86860760427344e-08 2.02570849518178e-06 0.834592644305917 0.842105263157895 5.4 5 4 kyphoscoliosis 0.00234316363466275 0.0150028817019912 0.834592644305917 0.842105263157895 5.4 5 4 small superior vagus ganglion 0.00234316363466275 0.0150028817019912 0.834592644305917 0.842105263157895 5.4 5 4 abnormal stationary movement 0.00234316363466275 0.0150028817019912 0.834592644305917 0.842105263157895 5.4 5 4 decreased chemically-elicited antinociception 0.00234316363466275 0.0150028817019912 0.834592644305917 0.842105263157895 5.4 5 4 maternal imprinting 0.00234316363466275 0.0150028817019912 0.834592644305917 0.842105263157895 5.4 5 4 abnormal sternebra morphology 0.00234316363466275 0.0150028817019912 0.834592644305917 0.842105263157895 5.4 5 4 abnormal cochlear inner hair cell morphology 0.00234316363466275 0.0150028817019912 0.834592644305917 0.842105263157895 5.4 5 4 abnormal blastocyst morphology 0.00234316363466275 0.0150028817019912 0.834592644305917 0.842105263157895 5.4 5 4 Leydig cell hypoplasia 0.00234316363466275 0.0150028817019912 0.834592644305917 0.842105263157895 5.4 5 4 abnormal behavior 1.24447115051406e-32 4.12749598253831e-30 0.834217377829161 0.841726618705036 5.4 5 4 reduced fertility 5.09221920806822e-17 5.17016133880396e-15 0.834217377829161 0.841726618705036 5.4 5 4 ataxia 4.50368494101971e-24 8.96233303262922e-22 0.834076188461668 0.841584158415842 5.4 5 4 double outlet right ventricle 2.25265051199932e-13 1.24521514413296e-11 0.833617652899017 0.841121495327103 5.4 5 4 abnormal motor capabilities/coordination/movement 3.72648879873447e-16 3.19642789201793e-14 0.83340714339071 0.840909090909091 5.4 5 4 perimembraneous ventricular septal defect 4.52318678481163e-09 1.36380934875381e-07 0.83308070110971 0.840579710144927 5.4 5 4 embryonic lethality before implantation, complete penetrance 2.72658739916937e-15 1.99481945748053e-13 0.832506162695152 0.84 5.4 5 4 abnormal interventricular septum morphology 6.67333738294301e-07 1.24344020524874e-05 0.832506162695152 0.84 5.4 5 4 abnormal axon extension 6.67333738294301e-07 1.24344020524874e-05 0.832506162695152 0.84 5.4 5 4 mandible hypoplasia 0.000490043441442505 0.00422927458211334 0.832506162695152 0.84 5.4 5 4 abnormal thyroid gland morphology 0.000490043441442505 0.00422927458211334 0.832506162695152 0.84 5.4 5 4 spontaneous skin ulceration 0.000490043441442505 0.00422927458211334 0.832506162695152 0.84 5.4 5 4 abnormal egg cylinder morphology 0.000490043441442505 0.00422927458211334 0.832506162695152 0.84 5.4 5 4 increased exploration in new environment 2.33502148769418e-10 8.93594761636812e-09 0.83201674108275 0.839506172839506 5.4 5 4 increased neuron apoptosis 2.33502148769418e-10 8.93594761636812e-09 0.83201674108275 0.839506172839506 5.4 5 4 osteopetrosis 0.000105082335336697 0.00112201957140039 0.831227351385328 0.838709677419355 5.4 5 4 abnormal capillary morphology 0.000105082335336697 0.00112201957140039 0.831227351385328 0.838709677419355 5.4 5 4 ventricular septal defect 2.42104304601349e-16 2.11310336033634e-14 0.830757200168481 0.838235294117647 5.4 5 4 pericardial edema 7.60909767904846e-09 2.22678005607447e-07 0.830757200168481 0.838235294117647 5.4 5 4 abnormal chromosome morphology 2.29045528812615e-05 0.000294444833551101 0.830363289689502 0.837837837837838 5.4 5 4 decreased embryo size 1.64334065268385e-53 1.16794567815745e-50 0.829354615157553 0.836820083682008 5.4 5 4 absent kidney 1.12290126732989e-06 1.99515493034507e-05 0.829269987135599 0.836734693877551 5.4 5 4 increased sarcoma incidence 1.12290126732989e-06 1.99515493034507e-05 0.829269987135599 0.836734693877551 5.4 5 4 abnormal platelet physiology 2.51300182837171e-07 5.1661917752683e-06 0.828902239912922 0.836363636363636 5.4 5 4 decreased circulating total protein level 2.51300182837171e-07 5.1661917752683e-06 0.828902239912922 0.836363636363636 5.4 5 4 internal hemorrhage 1.27660858364151e-08 3.50891033348978e-07 0.828364340990201 0.835820895522388 5.4 5 4 astrocytosis 2.8927069329432e-09 8.99451061962026e-08 0.828161707834381 0.835616438356164 5.4 5 4 cardiac fibrosis 1.49672763420404e-10 6.00501611303638e-09 0.827842262624031 0.835294117647059 5.4 5 4 impaired coordination 1.10595312582266e-38 4.23239753920594e-36 0.827808563924095 0.835260115606936 5.4 5 4 increased bone mineral content 4.09122115643328e-13 2.23668409376435e-11 0.827414381883561 0.834862385321101 5.4 5 4 neurodegeneration 4.20955430770496e-07 8.14884540110201e-06 0.82589897092773 0.833333333333333 5.4 5 4 curly tail 1.88256609211037e-06 3.21847639458732e-05 0.82589897092773 0.833333333333333 5.4 5 4 abnormal startle reflex 0.00082767190580526 0.00650500431497815 0.82589897092773 0.833333333333333 5.4 5 4 blindness 0.00082767190580526 0.00650500431497815 0.82589897092773 0.833333333333333 5.4 5 4 abnormal sensory capabilities/reflexes/nociception 0.00082767190580526 0.00650500431497815 0.82589897092773 0.833333333333333 5.4 5 4 abnormal cardiac muscle contractility 0.00082767190580526 0.00650500431497815 0.82589897092773 0.833333333333333 5.4 5 4 decreased fatty acid level 0.00082767190580526 0.00650500431497815 0.82589897092773 0.833333333333333 5.4 5 4 increased body temperature 0.00082767190580526 0.00650500431497815 0.82589897092773 0.833333333333333 5.4 5 4 abnormal lung saccule morphology 0.00082767190580526 0.00650500431497815 0.82589897092773 0.833333333333333 5.4 5 4 abnormal adipose tissue distribution 0.0200034661375026 0.0816627901593704 0.82589897092773 0.833333333333333 5.4 5 4 abnormal supraoccipital bone morphology 0.0200034661375026 0.0816627901593704 0.82589897092773 0.833333333333333 5.4 5 4 abnormal rectum morphology 0.0200034661375026 0.0816627901593704 0.82589897092773 0.833333333333333 5.4 5 4 increased papilloma incidence 0.0200034661375026 0.0816627901593704 0.82589897092773 0.833333333333333 5.4 5 4 abnormal embryonic growth/weight/body size 0.0200034661375026 0.0816627901593704 0.82589897092773 0.833333333333333 5.4 5 4 loss of dopaminergic neurons 0.0200034661375026 0.0816627901593704 0.82589897092773 0.833333333333333 5.4 5 4 dilated bile duct 0.0200034661375026 0.0816627901593704 0.82589897092773 0.833333333333333 5.4 5 4 abnormal vascular endothelial cell development 0.0200034661375026 0.0816627901593704 0.82589897092773 0.833333333333333 5.4 5 4 abnormal rostral-caudal body axis extension 0.0200034661375026 0.0816627901593704 0.82589897092773 0.833333333333333 5.4 5 4 small parietal bone 0.0200034661375026 0.0816627901593704 0.82589897092773 0.833333333333333 5.4 5 4 abnormal amacrine cell morphology 0.0200034661375026 0.0816627901593704 0.82589897092773 0.833333333333333 5.4 5 4 abnormal fatty acid level 0.0200034661375026 0.0816627901593704 0.82589897092773 0.833333333333333 5.4 5 4 reduced cerebellar foliation 0.0200034661375026 0.0816627901593704 0.82589897092773 0.833333333333333 5.4 5 4 decreased red blood cell distribution width 0.0200034661375026 0.0816627901593704 0.82589897092773 0.833333333333333 5.4 5 4 decreased mammary gland epithelial cell proliferation 0.0200034661375026 0.0816627901593704 0.82589897092773 0.833333333333333 5.4 5 4 increased fibrosarcoma incidence 0.0200034661375026 0.0816627901593704 0.82589897092773 0.833333333333333 5.4 5 4 abnormal pulmonary valve cusp morphology 0.0200034661375026 0.0816627901593704 0.82589897092773 0.833333333333333 5.4 5 4 prenatal growth retardation 0.0200034661375026 0.0816627901593704 0.82589897092773 0.833333333333333 5.4 5 4 abnormal respiratory motile cilium morphology 0.0200034661375026 0.0816627901593704 0.82589897092773 0.833333333333333 5.4 5 4 embryonic lethality between implantation and placentation, incomplete penetrance 0.0200034661375026 0.0816627901593704 0.82589897092773 0.833333333333333 5.4 5 4 abnormal vitelline vein connection 0.0200034661375026 0.0816627901593704 0.82589897092773 0.833333333333333 5.4 5 4 echinocytosis 0.111468576515728 0.287483757473172 0.82589897092773 0.833333333333333 5.4 5 4 poor arterial differentiation 0.111468576515728 0.287483757473172 0.82589897092773 0.833333333333333 5.4 5 4 absent organized vascular network 0.111468576515728 0.287483757473172 0.82589897092773 0.833333333333333 5.4 5 4 ectopic digits 0.111468576515728 0.287483757473172 0.82589897092773 0.833333333333333 5.4 5 4 hyperresponsive 0.111468576515728 0.287483757473172 0.82589897092773 0.833333333333333 5.4 5 4 jumpy 0.111468576515728 0.287483757473172 0.82589897092773 0.833333333333333 5.4 5 4 abnormal avoidance learning behavior 0.111468576515728 0.287483757473172 0.82589897092773 0.833333333333333 5.4 5 4 increased embryo size 0.111468576515728 0.287483757473172 0.82589897092773 0.833333333333333 5.4 5 4 delayed brain development 0.111468576515728 0.287483757473172 0.82589897092773 0.833333333333333 5.4 5 4 non-obstructive hydrocephaly 0.111468576515728 0.287483757473172 0.82589897092773 0.833333333333333 5.4 5 4 abnormal parental behavior 0.111468576515728 0.287483757473172 0.82589897092773 0.833333333333333 5.4 5 4 abnormal internal nares morphology 0.111468576515728 0.287483757473172 0.82589897092773 0.833333333333333 5.4 5 4 abnormal lymph node cortex morphology 0.111468576515728 0.287483757473172 0.82589897092773 0.833333333333333 5.4 5 4 abnormal cervical lymph node morphology 0.111468576515728 0.287483757473172 0.82589897092773 0.833333333333333 5.4 5 4 ectopic thymus 0.111468576515728 0.287483757473172 0.82589897092773 0.833333333333333 5.4 5 4 liver cirrhosis 0.111468576515728 0.287483757473172 0.82589897092773 0.833333333333333 5.4 5 4 phenotypic reversion 0.111468576515728 0.287483757473172 0.82589897092773 0.833333333333333 5.4 5 4 calcified joint 0.111468576515728 0.287483757473172 0.82589897092773 0.833333333333333 5.4 5 4 extremity edema 0.111468576515728 0.287483757473172 0.82589897092773 0.833333333333333 5.4 5 4 loss of hippocampal neurons 0.111468576515728 0.287483757473172 0.82589897092773 0.833333333333333 5.4 5 4 bile duct inflammation 0.111468576515728 0.287483757473172 0.82589897092773 0.833333333333333 5.4 5 4 esophageal atresia 0.111468576515728 0.287483757473172 0.82589897092773 0.833333333333333 5.4 5 4 increased glycerol level 0.111468576515728 0.287483757473172 0.82589897092773 0.833333333333333 5.4 5 4 enlarged pancreas 0.111468576515728 0.287483757473172 0.82589897092773 0.833333333333333 5.4 5 4 ureter obstruction 0.111468576515728 0.287483757473172 0.82589897092773 0.833333333333333 5.4 5 4 fusion of middle ear ossicles 0.111468576515728 0.287483757473172 0.82589897092773 0.833333333333333 5.4 5 4 abnormal milk ejection 0.111468576515728 0.287483757473172 0.82589897092773 0.833333333333333 5.4 5 4 abnormal serotonergic neuron morphology 0.111468576515728 0.287483757473172 0.82589897092773 0.833333333333333 5.4 5 4 abnormal ST segment 0.111468576515728 0.287483757473172 0.82589897092773 0.833333333333333 5.4 5 4 shortened QT interval 0.111468576515728 0.287483757473172 0.82589897092773 0.833333333333333 5.4 5 4 absent molars 0.111468576515728 0.287483757473172 0.82589897092773 0.833333333333333 5.4 5 4 abnormal cholesterol level 0.111468576515728 0.287483757473172 0.82589897092773 0.833333333333333 5.4 5 4 abnormal motor nerve collateral sprouting 0.111468576515728 0.287483757473172 0.82589897092773 0.833333333333333 5.4 5 4 abnormal extensor digitorum longus morphology 0.111468576515728 0.287483757473172 0.82589897092773 0.833333333333333 5.4 5 4 abnormal physical strength 0.111468576515728 0.287483757473172 0.82589897092773 0.833333333333333 5.4 5 4 small clavicle 0.111468576515728 0.287483757473172 0.82589897092773 0.833333333333333 5.4 5 4 enlarged interparietal bone 0.111468576515728 0.287483757473172 0.82589897092773 0.833333333333333 5.4 5 4 decreased cochlear microphonics 0.111468576515728 0.287483757473172 0.82589897092773 0.833333333333333 5.4 5 4 absent parietal bone 0.111468576515728 0.287483757473172 0.82589897092773 0.833333333333333 5.4 5 4 abnormal immature B cell morphology 0.111468576515728 0.287483757473172 0.82589897092773 0.833333333333333 5.4 5 4 abnormal anus morphology 0.111468576515728 0.287483757473172 0.82589897092773 0.833333333333333 5.4 5 4 decreased triiodothyronine level 0.111468576515728 0.287483757473172 0.82589897092773 0.833333333333333 5.4 5 4 increased triiodothyronine level 0.111468576515728 0.287483757473172 0.82589897092773 0.833333333333333 5.4 5 4 abnormal ligament morphology 0.111468576515728 0.287483757473172 0.82589897092773 0.833333333333333 5.4 5 4 delayed chorioallantoic fusion 0.111468576515728 0.287483757473172 0.82589897092773 0.833333333333333 5.4 5 4 abnormal aorta tunica adventitia morphology 0.111468576515728 0.287483757473172 0.82589897092773 0.833333333333333 5.4 5 4 absent tongue 0.111468576515728 0.287483757473172 0.82589897092773 0.833333333333333 5.4 5 4 increased transitional stage T1 B cell number 0.111468576515728 0.287483757473172 0.82589897092773 0.833333333333333 5.4 5 4 abnormal olfactory bulb layer morphology 0.111468576515728 0.287483757473172 0.82589897092773 0.833333333333333 5.4 5 4 visceral vascular congestion 0.111468576515728 0.287483757473172 0.82589897092773 0.833333333333333 5.4 5 4 abnormal orbit morphology 0.111468576515728 0.287483757473172 0.82589897092773 0.833333333333333 5.4 5 4 abnormal acute phase protein level 0.111468576515728 0.287483757473172 0.82589897092773 0.833333333333333 5.4 5 4 abnormal heart right ventricle outflow tract morphology 0.111468576515728 0.287483757473172 0.82589897092773 0.833333333333333 5.4 5 4 cerebral arteriovenous malformation 0.111468576515728 0.287483757473172 0.82589897092773 0.833333333333333 5.4 5 4 thick pulmonary valve cusps 0.111468576515728 0.287483757473172 0.82589897092773 0.833333333333333 5.4 5 4 thick myocardium 0.111468576515728 0.287483757473172 0.82589897092773 0.833333333333333 5.4 5 4 persistent hyperplastic primary vitreous 0.111468576515728 0.287483757473172 0.82589897092773 0.833333333333333 5.4 5 4 abnormal pre-Botzinger complex physiology 0.111468576515728 0.287483757473172 0.82589897092773 0.833333333333333 5.4 5 4 increased total lung capacity 0.111468576515728 0.287483757473172 0.82589897092773 0.833333333333333 5.4 5 4 abnormal mandibular prominence morphology 0.111468576515728 0.287483757473172 0.82589897092773 0.833333333333333 5.4 5 4 decreased compact bone mass 0.111468576515728 0.287483757473172 0.82589897092773 0.833333333333333 5.4 5 4 abnormal ureteric bud tip morphology 0.111468576515728 0.287483757473172 0.82589897092773 0.833333333333333 5.4 5 4 abnormal kidney collecting duct epithelium morphology 0.111468576515728 0.287483757473172 0.82589897092773 0.833333333333333 5.4 5 4 podocyte hypertrophy 0.111468576515728 0.287483757473172 0.82589897092773 0.833333333333333 5.4 5 4 abnormal endocrine pancreas development 0.111468576515728 0.287483757473172 0.82589897092773 0.833333333333333 5.4 5 4 absent midbrain 0.111468576515728 0.287483757473172 0.82589897092773 0.833333333333333 5.4 5 4 thymus cortex atrophy 0.111468576515728 0.287483757473172 0.82589897092773 0.833333333333333 5.4 5 4 increased CD11b-high dendritic cell number 0.111468576515728 0.287483757473172 0.82589897092773 0.833333333333333 5.4 5 4 ciliary body hypoplasia 0.111468576515728 0.287483757473172 0.82589897092773 0.833333333333333 5.4 5 4 additional anastomosis between intracranial vertebral arteries 0.111468576515728 0.287483757473172 0.82589897092773 0.833333333333333 5.4 5 4 increased body fat mass 0.111468576515728 0.287483757473172 0.82589897092773 0.833333333333333 5.4 5 4 ectopic bone 0.111468576515728 0.287483757473172 0.82589897092773 0.833333333333333 5.4 5 4 decreased tear production 0.111468576515728 0.287483757473172 0.82589897092773 0.833333333333333 5.4 5 4 abnormal inhibitory learning 0.111468576515728 0.287483757473172 0.82589897092773 0.833333333333333 5.4 5 4 decreased retinal apoptosis 0.111468576515728 0.287483757473172 0.82589897092773 0.833333333333333 5.4 5 4 increased cardiac cell glucose uptake 0.111468576515728 0.287483757473172 0.82589897092773 0.833333333333333 5.4 5 4 hydrops fetalis 4.8377340273513e-09 1.44986305940197e-07 0.82589897092773 0.833333333333333 5.4 5 4 disorganized myocardium 0.000176970732189166 0.00173916041043337 0.82589897092773 0.833333333333333 5.4 5 4 abnormal optic cup morphology 0.000176970732189166 0.00173916041043337 0.82589897092773 0.833333333333333 5.4 5 4 lowered ear position 0.0039754655798206 0.0232119232861295 0.82589897092773 0.833333333333333 5.4 5 4 abnormal heart shape 0.0039754655798206 0.0232119232861295 0.82589897092773 0.833333333333333 5.4 5 4 absent spleen 0.0039754655798206 0.0232119232861295 0.82589897092773 0.833333333333333 5.4 5 4 abnormal thyroid cartilage morphology 0.0039754655798206 0.0232119232861295 0.82589897092773 0.833333333333333 5.4 5 4 abnormal thymus medulla morphology 0.0039754655798206 0.0232119232861295 0.82589897092773 0.833333333333333 5.4 5 4 abnormal bile duct morphology 0.0039754655798206 0.0232119232861295 0.82589897092773 0.833333333333333 5.4 5 4 absent allantois 0.0039754655798206 0.0232119232861295 0.82589897092773 0.833333333333333 5.4 5 4 absent ureter 0.0039754655798206 0.0232119232861295 0.82589897092773 0.833333333333333 5.4 5 4 jerky movement 0.0039754655798206 0.0232119232861295 0.82589897092773 0.833333333333333 5.4 5 4 decreased lactate dehydrogenase level 0.0039754655798206 0.0232119232861295 0.82589897092773 0.833333333333333 5.4 5 4 decreased pulmonary respiratory rate 0.0039754655798206 0.0232119232861295 0.82589897092773 0.833333333333333 5.4 5 4 increased gastrointestinal tumor incidence 0.0039754655798206 0.0232119232861295 0.82589897092773 0.833333333333333 5.4 5 4 increased effector memory CD8-positive, alpha-beta T cell number 0.0039754655798206 0.0232119232861295 0.82589897092773 0.833333333333333 5.4 5 4 increased startle reflex 9.51404967748267e-11 3.97751236516608e-09 0.824043018184072 0.831460674157303 5.4 5 4 pale yolk sac 4.17132290420501e-10 1.51476871886277e-08 0.823908852925495 0.831325301204819 5.4 5 4 increased tumor incidence 2.29146880386877e-14 1.4430452277528e-12 0.823234780698931 0.830645161290323 5.4 5 4 embryonic lethality during organogenesis, complete penetrance 5.63078329410415e-60 4.66885781469469e-57 0.822949331745845 0.830357142857143 5.4 5 4 abnormal suckling behavior 1.58287262670681e-10 6.29983305429311e-09 0.82214488469624 0.829545454545455 5.4 5 4 abnormal mammary gland development 1.41640149542589e-05 0.000193587841751204 0.82187019545979 0.829268292682927 5.4 5 4 lordosis 0.000296312907403576 0.00269304389525985 0.820203115955815 0.827586206896552 5.4 5 4 increased mortality induced by gamma-irradiation 0.000296312907403576 0.00269304389525985 0.820203115955815 0.827586206896552 5.4 5 4 abnormal placenta vasculature 1.16895076508766e-06 2.06224470081954e-05 0.819545901920594 0.826923076923077 5.4 5 4 lethality throughout fetal growth and development, complete penetrance 1.06446723125346e-20 1.51306413585313e-18 0.818944032225181 0.826315789473684 5.4 5 4 microcephaly 2.22671744266736e-08 5.76974962357819e-07 0.81871724074575 0.826086956521739 5.4 5 4 abnormal cell death 5.23021718129293e-06 8.00625553136379e-05 0.81871724074575 0.826086956521739 5.4 5 4 abnormal allantois morphology 5.23021718129293e-06 8.00625553136379e-05 0.81871724074575 0.826086956521739 5.4 5 4 abnormal blood vessel physiology 0.00138810460562592 0.00992215576578871 0.81871724074575 0.826086956521739 5.4 5 4 abnormal cardiovascular development 0.00138810460562592 0.00992215576578871 0.81871724074575 0.826086956521739 5.4 5 4 abnormal corneal stroma morphology 0.00138810460562592 0.00992215576578871 0.81871724074575 0.826086956521739 5.4 5 4 abnormal palatal shelf fusion at midline 0.00138810460562592 0.00992215576578871 0.81871724074575 0.826086956521739 5.4 5 4 abnormal basicranium morphology 0.00138810460562592 0.00992215576578871 0.81871724074575 0.826086956521739 5.4 5 4 edema 8.66742756906369e-19 1.0780113039023e-16 0.818216189802821 0.825581395348837 5.4 5 4 abnormal social investigation 1.90675555287883e-09 6.00386637694442e-08 0.817639981218453 0.825 5.4 5 4 abnormal posture 1.90675555287883e-09 6.00386637694442e-08 0.817639981218453 0.825 5.4 5 4 kidney cysts 8.37068374682402e-09 2.42117160700288e-07 0.816970333404187 0.824324324324324 5.4 5 4 abnormal gastrulation 1.93728205837885e-06 3.27599796919848e-05 0.816182512446228 0.823529411764706 5.4 5 4 enlarged liver sinusoidal spaces 0.00010712168997687 0.00113389448432963 0.816182512446227 0.823529411764706 5.4 5 4 abnormal direction of heart looping 0.00010712168997687 0.00113389448432963 0.816182512446227 0.823529411764706 5.4 5 4 abnormal bone marrow cavity morphology 0.00668462273797583 0.0354541557797759 0.816182512446227 0.823529411764706 5.4 5 4 abnormal vagus nerve morphology 0.00668462273797583 0.0354541557797759 0.816182512446227 0.823529411764706 5.4 5 4 increased aggression towards mice 0.00668462273797583 0.0354541557797759 0.816182512446227 0.823529411764706 5.4 5 4 decreased vasoconstriction 0.00668462273797583 0.0354541557797759 0.816182512446227 0.823529411764706 5.4 5 4 increased regulatory T cell number 0.00668462273797583 0.0354541557797759 0.816182512446227 0.823529411764706 5.4 5 4 abnormal tarsal bone morphology 0.00668462273797583 0.0354541557797759 0.816182512446227 0.823529411764706 5.4 5 4 coloboma 0.00668462273797583 0.0354541557797759 0.816182512446227 0.823529411764706 5.4 5 4 enhanced behavioral response to cocaine 0.00668462273797583 0.0354541557797759 0.816182512446227 0.823529411764706 5.4 5 4 decreased body fat mass 0.00668462273797583 0.0354541557797759 0.816182512446227 0.823529411764706 5.4 5 4 trabecula carnea hypoplasia 8.66422559441369e-06 0.000128287268845857 0.814886984648694 0.822222222222222 5.4 5 4 abnormal cell migration 8.66422559441369e-06 0.000128287268845857 0.814886984648694 0.822222222222222 5.4 5 4 embryonic lethality during organogenesis, incomplete penetrance 4.73385281598043e-24 9.0580452921164e-22 0.814408202636562 0.821739130434783 5.4 5 4 decreased exploration in new environment 1.18524426638748e-09 3.90502663925676e-08 0.814100414200191 0.821428571428571 5.4 5 4 abnormal jaw morphology 0.000493061157311706 0.00422927458211334 0.814100414200191 0.821428571428571 5.4 5 4 abnormal somite shape 0.000493061157311706 0.00422927458211334 0.814100414200191 0.821428571428571 5.4 5 4 absent corpus callosum 0.000493061157311706 0.00422927458211334 0.814100414200191 0.821428571428571 5.4 5 4 abnormal mitotic spindle morphology 0.000493061157311706 0.00422927458211334 0.814100414200191 0.821428571428571 5.4 5 4 embryonic growth arrest 7.79005670197183e-24 1.38412614615392e-21 0.813636715464174 0.820960698689956 5.4 5 4 abnormal forebrain development 2.27357865175056e-08 5.84785952178909e-07 0.812133988078935 0.819444444444444 5.4 5 4 dilated heart atrium 0.000177237050872305 0.00173916041043337 0.810882626001772 0.818181818181818 5.4 5 4 decreased circulating serum albumin level 6.34177269415033e-11 2.76757185556122e-09 0.810882626001771 0.818181818181818 5.4 5 4 abnormal astrocyte morphology 1.42905029317731e-05 0.000194781512563209 0.810882626001771 0.818181818181818 5.4 5 4 increased body size 0.00231025591144459 0.0149655249471834 0.810882626001771 0.818181818181818 5.4 5 4 increased skin papilloma incidence 0.00231025591144459 0.0149655249471834 0.810882626001771 0.818181818181818 5.4 5 4 abnormal blood-brain barrier function 0.00231025591144459 0.0149655249471834 0.810882626001771 0.818181818181818 5.4 5 4 pulmonary vascular congestion 0.00231025591144459 0.0149655249471834 0.810882626001771 0.818181818181818 5.4 5 4 increased adenoma incidence 0.00231025591144459 0.0149655249471834 0.810882626001771 0.818181818181818 5.4 5 4 embryonic lethality before implantation, incomplete penetrance 0.00231025591144459 0.0149655249471834 0.810882626001771 0.818181818181818 5.4 5 4 delayed hepatic development 0.033790663614025 0.121290441183098 0.810882626001771 0.818181818181818 5.4 5 4 abnormal proximal-distal axis patterning 0.033790663614025 0.121290441183098 0.810882626001771 0.818181818181818 5.4 5 4 vasculitis 0.033790663614025 0.121290441183098 0.810882626001771 0.818181818181818 5.4 5 4 patent ductus arteriosus 0.033790663614025 0.121290441183098 0.810882626001771 0.818181818181818 5.4 5 4 fused joints 0.033790663614025 0.121290441183098 0.810882626001771 0.818181818181818 5.4 5 4 loss of cortex neurons 0.033790663614025 0.121290441183098 0.810882626001771 0.818181818181818 5.4 5 4 rectal hemorrhage 0.033790663614025 0.121290441183098 0.810882626001771 0.818181818181818 5.4 5 4 pulmonary hypertension 0.033790663614025 0.121290441183098 0.810882626001771 0.818181818181818 5.4 5 4 abnormal radial glial cell morphology 0.033790663614025 0.121290441183098 0.810882626001771 0.818181818181818 5.4 5 4 dilated renal glomerular capsule 0.033790663614025 0.121290441183098 0.810882626001771 0.818181818181818 5.4 5 4 abnormal pituitary gland development 0.033790663614025 0.121290441183098 0.810882626001771 0.818181818181818 5.4 5 4 abnormal coronal suture morphology 0.033790663614025 0.121290441183098 0.810882626001771 0.818181818181818 5.4 5 4 cyclopia 0.033790663614025 0.121290441183098 0.810882626001771 0.818181818181818 5.4 5 4 abnormal dorsal-ventral polarity of the somites 0.033790663614025 0.121290441183098 0.810882626001771 0.818181818181818 5.4 5 4 increased glycogen level 0.033790663614025 0.121290441183098 0.810882626001771 0.818181818181818 5.4 5 4 abnormal platelet aggregation 0.033790663614025 0.121290441183098 0.810882626001771 0.818181818181818 5.4 5 4 abnormal palate development 0.033790663614025 0.121290441183098 0.810882626001771 0.818181818181818 5.4 5 4 aorta dilation 0.033790663614025 0.121290441183098 0.810882626001771 0.818181818181818 5.4 5 4 abnormal pulmonary alveolar sac morphology 0.033790663614025 0.121290441183098 0.810882626001771 0.818181818181818 5.4 5 4 abnormal brain ependyma motile cilium morphology 0.033790663614025 0.121290441183098 0.810882626001771 0.818181818181818 5.4 5 4 reduced sympathetic cervical ganglion size 0.033790663614025 0.121290441183098 0.810882626001771 0.818181818181818 5.4 5 4 abnormal nervous system physiology 2.08269473722431e-12 1.04660669875666e-10 0.810099164527374 0.817391304347826 5.4 5 4 cleft palate 6.88169783531431e-14 4.12487310008297e-12 0.809507082955119 0.816793893129771 5.4 5 4 increased erythrocyte cell number 4.39808033395439e-07 8.44805006232552e-06 0.809380991509176 0.816666666666667 5.4 5 4 abnormal embryonic tissue morphology 2.2831636995656e-15 1.69533423960281e-13 0.809043889888389 0.816326530612245 5.4 5 4 abnormal frontal bone morphology 6.42707730180306e-05 0.000733774268434128 0.808511624171357 0.815789473684211 5.4 5 4 persistence of hyaloid vascular system 6.42707730180306e-05 0.000733774268434128 0.808511624171357 0.815789473684211 5.4 5 4 increased grooming behavior 6.42707730180306e-05 0.000733774268434128 0.808511624171357 0.815789473684211 5.4 5 4 incomplete somite formation 6.42707730180306e-05 0.000733774268434128 0.808511624171357 0.815789473684211 5.4 5 4 decreased neuron apoptosis 6.42707730180306e-05 0.000733774268434128 0.808511624171357 0.815789473684211 5.4 5 4 abnormal retinal outer nuclear layer morphology 6.42707730180306e-05 0.000733774268434128 0.808511624171357 0.815789473684211 5.4 5 4 decreased total retina thickness 6.42707730180306e-05 0.000733774268434128 0.808511624171357 0.815789473684211 5.4 5 4 lethality throughout fetal growth and development, incomplete penetrance 2.53068748770365e-18 2.92794657007573e-16 0.808365920148259 0.815642458100559 5.4 5 4 abnormal rib morphology 4.2531046606524e-14 2.58038971789582e-12 0.80754566046267 0.814814814814815 5.4 5 4 abnormal cell adhesion 1.94255155962523e-06 3.27599796919848e-05 0.80754566046267 0.814814814814815 5.4 5 4 abnormal osteoblast physiology 1.94255155962523e-06 3.27599796919848e-05 0.80754566046267 0.814814814814815 5.4 5 4 abnormal brain commissure morphology 0.000814998723666011 0.00647702659782493 0.80754566046267 0.814814814814815 5.4 5 4 abnormal type II pneumocyte morphology 0.000814998723666011 0.00647702659782493 0.80754566046267 0.814814814814815 5.4 5 4 abnormal eye muscle morphology 0.000814998723666011 0.00647702659782493 0.80754566046267 0.814814814814815 5.4 5 4 decreased circulating fructosamine level 0.000814998723666011 0.00647702659782493 0.80754566046267 0.814814814814815 5.4 5 4 thick interventricular septum 0.000814998723666011 0.00647702659782493 0.80754566046267 0.814814814814815 5.4 5 4 domed cranium 6.10445092271701e-08 1.43931958959797e-06 0.807021280163668 0.814285714285714 5.4 5 4 abnormal double-strand DNA break repair 2.3463025886052e-05 0.000300846788100796 0.806692018115457 0.813953488372093 5.4 5 4 abnormal brain morphology 2.02247602241528e-16 1.82942149300291e-14 0.806405703290927 0.813664596273292 5.4 5 4 delayed bone ossification 2.28037135121022e-08 5.84785952178909e-07 0.806077395625465 0.813333333333333 5.4 5 4 abnormal phalanx morphology 8.61091105469332e-06 0.000128261324841615 0.805251496654537 0.8125 5.4 5 4 decreased circulating LDL cholesterol level 2.67419200071575e-07 5.40266824144374e-06 0.805251496654537 0.8125 5.4 5 4 increased sacral vertebrae number 2.67419200071575e-07 5.40266824144374e-06 0.805251496654537 0.8125 5.4 5 4 abnormal vertebral body morphology 0.000291522781078604 0.00266604013945966 0.805251496654537 0.8125 5.4 5 4 kidney cortex cysts 0.000291522781078604 0.00266604013945966 0.805251496654537 0.8125 5.4 5 4 neonatal lethality 0.000291522781078604 0.00266604013945966 0.805251496654537 0.8125 5.4 5 4 increased fibroblast apoptosis 0.000291522781078604 0.00266604013945966 0.805251496654537 0.8125 5.4 5 4 impaired muscle relaxation 0.0111280242570637 0.0528500749624308 0.805251496654537 0.8125 5.4 5 4 decreased aggression towards mice 0.0111280242570637 0.0528500749624308 0.805251496654537 0.8125 5.4 5 4 loose skin 0.0111280242570637 0.0528500749624308 0.805251496654537 0.8125 5.4 5 4 decreased fibroblast apoptosis 0.0111280242570637 0.0528500749624308 0.805251496654537 0.8125 5.4 5 4 abnormal hepatocyte morphology 1.47360369853778e-11 6.85156859834156e-10 0.803577377118873 0.810810810810811 5.4 5 4 impaired skeletal muscle contractility 0.000105323244189745 0.00112201957140039 0.803577377118872 0.810810810810811 5.4 5 4 abnormal calcium ion homeostasis 0.000105323244189745 0.00112201957140039 0.803577377118872 0.810810810810811 5.4 5 4 abnormal pancreas morphology 3.83392776537445e-05 0.00046295608331888 0.802301857472652 0.80952380952381 5.4 5 4 abnormal associative learning 0.00381302501553944 0.0231621482934173 0.802301857472652 0.80952380952381 5.4 5 4 liver degeneration 0.00381302501553944 0.0231621482934173 0.802301857472652 0.80952380952381 5.4 5 4 abnormal tumor vascularization 0.00381302501553944 0.0231621482934173 0.802301857472652 0.80952380952381 5.4 5 4 abnormal neural tube morphology 5.32800635435107e-16 4.34538223162239e-14 0.801427890307649 0.808641975308642 5.4 5 4 increased circulating alkaline phosphatase level 5.32800635435107e-16 4.34538223162239e-14 0.801427890307649 0.808641975308642 5.4 5 4 abnormal innervation 1.40381375735745e-05 0.000192395962613039 0.801297724985202 0.808510638297872 5.4 5 4 neuron degeneration 1.40381375735745e-05 0.000192395962613039 0.801297724985202 0.808510638297872 5.4 5 4 decreased bone trabecula number 1.40381375735745e-05 0.000192395962613039 0.801297724985202 0.808510638297872 5.4 5 4 abnormal bone structure 9.60771069349789e-19 1.16581367561346e-16 0.801079209107104 0.808290155440414 5.4 5 4 ventricular hypoplasia 0.0013375258460157 0.00978557512342369 0.800486694899185 0.807692307692308 5.4 5 4 abnormal ureter morphology 0.0013375258460157 0.00978557512342369 0.800486694899185 0.807692307692308 5.4 5 4 no spontaneous movement 0.0013375258460157 0.00978557512342369 0.800486694899185 0.807692307692308 5.4 5 4 increased thymocyte apoptosis 0.0013375258460157 0.00978557512342369 0.800486694899185 0.807692307692308 5.4 5 4 abnormal definitive hematopoiesis 1.1816452781229e-09 3.90502663925676e-08 0.799257068639739 0.806451612903226 5.4 5 4 abnormal postnatal growth/weight/body size 0.000476505719074449 0.00415169168545601 0.799257068639739 0.806451612903226 5.4 5 4 abnormal craniofacial morphology 1.66514189303444e-10 6.57466739511616e-09 0.798636286450504 0.805825242718447 5.4 5 4 abnormal digit morphology 9.76879846510907e-08 2.20908056199626e-06 0.798369005230139 0.805555555555556 5.4 5 4 abnormal limb bone morphology 0.000171638458421125 0.001697616959533 0.798369005230139 0.805555555555556 5.4 5 4 increased bone trabecula number 6.23339900231609e-05 0.000726256675328396 0.797697542652149 0.804878048780488 5.4 5 4 lethality at weaning, incomplete penetrance 6.23339900231609e-05 0.000726256675328396 0.797697542652149 0.804878048780488 5.4 5 4 abnormal heart development 3.62355332167765e-15 2.61263446019512e-13 0.796626602337887 0.80379746835443 5.4 5 4 decreased startle reflex 1.42779001793221e-11 6.70118428227618e-10 0.796251315561094 0.803418803418803 5.4 5 4 abnormal vascular development 4.23875933273207e-07 8.17357662028761e-06 0.795866281075813 0.803030303030303 5.4 5 4 abnormal skeletal muscle fiber morphology 1.5767858054648e-07 3.41065625312494e-06 0.795654783259954 0.802816901408451 5.4 5 4 increased circulating creatinine level 8.20713146506094e-09 2.3877473122034e-07 0.795167846428094 0.802325581395349 5.4 5 4 increased grip strength 3.07321818554613e-09 9.49643507645465e-08 0.795041207178782 0.802197802197802 5.4 5 4 decreased body size 2.19574977135316e-70 2.73096377812049e-67 0.794850137434207 0.802005012531328 5.4 5 4 abnormal liver physiology 6.94247794467861e-10 2.36567313525863e-08 0.792863012090621 0.8 5.4 5 4 abnormal head morphology 4.97514161224433e-06 7.66295031607292e-05 0.792863012090621 0.8 5.4 5 4 abnormal embryo turning 4.97514161224433e-06 7.66295031607292e-05 0.792863012090621 0.8 5.4 5 4 decreased circulating alkaline phosphatase level 1.35012131905942e-05 0.000187621607886051 0.792863012090621 0.8 5.4 5 4 testicular atrophy 1.35012131905942e-05 0.000187621607886051 0.792863012090621 0.8 5.4 5 4 abnormal vertebrae development 0.00217818576325627 0.0143529459234436 0.792863012090621 0.8 5.4 5 4 hemorrhage 2.58686392077859e-21 3.78519058996279e-19 0.792863012090621 0.8 5.4 5 4 intracranial hemorrhage 1.83977060794533e-06 3.15615819811312e-05 0.792863012090621 0.8 5.4 5 4 muscular ventricular septal defect 1.83977060794533e-06 3.15615819811312e-05 0.792863012090621 0.8 5.4 5 4 lethality at weaning, complete penetrance 3.6795612281211e-05 0.000446483344143963 0.792863012090621 0.8 5.4 5 4 perinatal lethality 0.000100813126072742 0.00108325119268227 0.792863012090621 0.8 5.4 5 4 liver hemorrhage 0.000773681608261215 0.00626504645957676 0.792863012090621 0.8 5.4 5 4 increased mammary adenocarcinoma incidence 0.00623600277517314 0.0335395824934988 0.792863012090621 0.8 5.4 5 4 abnormal neuron proliferation 0.00623600277517314 0.0335395824934988 0.792863012090621 0.8 5.4 5 4 abnormal heart electrocardiography waveform feature 0.00623600277517314 0.0335395824934988 0.792863012090621 0.8 5.4 5 4 abnormal fontanelle morphology 0.0183180173676738 0.0771652298087866 0.792863012090621 0.8 5.4 5 4 hyperpigmentation 0.0183180173676738 0.0771652298087866 0.792863012090621 0.8 5.4 5 4 no suckling reflex 0.0183180173676738 0.0771652298087866 0.792863012090621 0.8 5.4 5 4 audiogenic seizures 0.0183180173676738 0.0771652298087866 0.792863012090621 0.8 5.4 5 4 abnormal bronchus morphology 0.0183180173676738 0.0771652298087866 0.792863012090621 0.8 5.4 5 4 decreased aggression towards males 0.0183180173676738 0.0771652298087866 0.792863012090621 0.8 5.4 5 4 abnormal olfactory nerve morphology 0.0183180173676738 0.0771652298087866 0.792863012090621 0.8 5.4 5 4 abnormal cerebral aqueduct morphology 0.0183180173676738 0.0771652298087866 0.792863012090621 0.8 5.4 5 4 abnormal Muller cell morphology 0.0183180173676738 0.0771652298087866 0.792863012090621 0.8 5.4 5 4 abnormal aorta wall morphology 0.0183180173676738 0.0771652298087866 0.792863012090621 0.8 5.4 5 4 liver vascular congestion 0.0183180173676738 0.0771652298087866 0.792863012090621 0.8 5.4 5 4 abnormal microglial cell activation 0.0183180173676738 0.0771652298087866 0.792863012090621 0.8 5.4 5 4 decreased trabecular bone mass 0.0183180173676738 0.0771652298087866 0.792863012090621 0.8 5.4 5 4 decreased brown adipose tissue mass 0.0183180173676738 0.0771652298087866 0.792863012090621 0.8 5.4 5 4 retarded hair growth 0.0562541614637647 0.182501717620361 0.792863012090621 0.8 5.4 5 4 absent maxillary shelf 0.0562541614637647 0.182501717620361 0.792863012090621 0.8 5.4 5 4 increased cranium width 0.0562541614637647 0.182501717620361 0.792863012090621 0.8 5.4 5 4 abnormal epidermis suprabasal layer morphology 0.0562541614637647 0.182501717620361 0.792863012090621 0.8 5.4 5 4 fused cornea and lens 0.0562541614637647 0.182501717620361 0.792863012090621 0.8 5.4 5 4 abnormal optic nerve innervation 0.0562541614637647 0.182501717620361 0.792863012090621 0.8 5.4 5 4 impaired social transmission of food preference 0.0562541614637647 0.182501717620361 0.792863012090621 0.8 5.4 5 4 abnormal primordial germ cell migration 0.0562541614637647 0.182501717620361 0.792863012090621 0.8 5.4 5 4 abnormal bone healing 0.0562541614637647 0.182501717620361 0.792863012090621 0.8 5.4 5 4 acrania 0.0562541614637647 0.182501717620361 0.792863012090621 0.8 5.4 5 4 peritoneal inflammation 0.0562541614637647 0.182501717620361 0.792863012090621 0.8 5.4 5 4 abnormal pillar cell morphology 0.0562541614637647 0.182501717620361 0.792863012090621 0.8 5.4 5 4 abnormal hindlimb zeugopod morphology 0.0562541614637647 0.182501717620361 0.792863012090621 0.8 5.4 5 4 abnormal gas homeostasis 0.0562541614637647 0.182501717620361 0.792863012090621 0.8 5.4 5 4 abnormal plasma membrane morphology 0.0562541614637647 0.182501717620361 0.792863012090621 0.8 5.4 5 4 abnormal respiratory conducting tube morphology 0.0562541614637647 0.182501717620361 0.792863012090621 0.8 5.4 5 4 abnormal corneal endothelium morphology 0.0562541614637647 0.182501717620361 0.792863012090621 0.8 5.4 5 4 tachypnea 0.0562541614637647 0.182501717620361 0.792863012090621 0.8 5.4 5 4 vascular smooth muscle hyperplasia 0.0562541614637647 0.182501717620361 0.792863012090621 0.8 5.4 5 4 abnormal spinal cord dorsal column morphology 0.0562541614637647 0.182501717620361 0.792863012090621 0.8 5.4 5 4 impaired behavioral response to morphine 0.0562541614637647 0.182501717620361 0.792863012090621 0.8 5.4 5 4 abnormal sperm principal piece morphology 0.0562541614637647 0.182501717620361 0.792863012090621 0.8 5.4 5 4 umbilical hernia 0.0562541614637647 0.182501717620361 0.792863012090621 0.8 5.4 5 4 acanthocytosis 0.0562541614637647 0.182501717620361 0.792863012090621 0.8 5.4 5 4 thick aortic valve 0.0562541614637647 0.182501717620361 0.792863012090621 0.8 5.4 5 4 abnormal pulmonary interalveolar septum morphology 0.0562541614637647 0.182501717620361 0.792863012090621 0.8 5.4 5 4 abnormal adaptive thermogenesis 0.0562541614637647 0.182501717620361 0.792863012090621 0.8 5.4 5 4 abnormal circadian temperature homeostasis 0.0562541614637647 0.182501717620361 0.792863012090621 0.8 5.4 5 4 increased fatty acid oxidation 0.0562541614637647 0.182501717620361 0.792863012090621 0.8 5.4 5 4 thick pulmonary interalveolar septum 0.000278065085595201 0.00258092127021665 0.792863012090621 0.8 5.4 5 4 abnormal artery morphology 0.000278065085595201 0.00258092127021665 0.792863012090621 0.8 5.4 5 4 decreased circulating thyroxine level 0.000278065085595201 0.00258092127021665 0.792863012090621 0.8 5.4 5 4 increased red blood cell distribution width 0.000278065085595201 0.00258092127021665 0.792863012090621 0.8 5.4 5 4 decreased bone volume 0.000278065085595201 0.00258092127021665 0.792863012090621 0.8 5.4 5 4 decreased grip strength 7.68008254455966e-20 1.03265974754552e-17 0.79195791732796 0.799086757990868 5.4 5 4 prenatal lethality, complete penetrance 1.03994098175574e-24 2.3317160946389e-22 0.791436999478947 0.798561151079137 5.4 5 4 increased anxiety-related response 4.47778002056423e-13 2.42140821764207e-11 0.791436999478947 0.798561151079137 5.4 5 4 abnormal cranium morphology 1.18756144589507e-12 6.09084349827624e-11 0.791383790053139 0.798507462686567 5.4 5 4 respiratory distress 7.82002362572365e-16 6.27493831257664e-14 0.790571500494983 0.797687861271676 5.4 5 4 decreased blood urea nitrogen level 5.91339484860256e-05 0.000695487928411294 0.788358108612833 0.795454545454545 5.4 5 4 increased hepatocyte apoptosis 0.000162144438868839 0.00161333716674495 0.787780556884912 0.794871794871795 5.4 5 4 decreased trabecular bone volume 0.000162144438868839 0.00161333716674495 0.787780556884912 0.794871794871795 5.4 5 4 infertility 3.99880146967494e-10 1.46279686114947e-08 0.787305561071294 0.794392523364486 5.4 5 4 lung hemorrhage 0.000447682014326127 0.00394896812282355 0.787033137001719 0.794117647058823 5.4 5 4 abnormal bone remodeling 0.000447682014326127 0.00394896812282355 0.787033137001719 0.794117647058823 5.4 5 4 abnormal embryonic neuroepithelium morphology 4.71789536763201e-06 7.33485295436539e-05 0.786027986124322 0.793103448275862 5.4 5 4 abnormal parietal bone morphology 0.00124726278195953 0.00917918985243888 0.786027986124322 0.793103448275862 5.4 5 4 abnormal spinal nerve morphology 0.00124726278195953 0.00917918985243888 0.786027986124322 0.793103448275862 5.4 5 4 abnormal outer ear morphology 0.00124726278195953 0.00917918985243888 0.786027986124322 0.793103448275862 5.4 5 4 blood in lymph vessels 0.00124726278195953 0.00917918985243888 0.786027986124322 0.793103448275862 5.4 5 4 abnormal developmental patterning 5.3808730437587e-08 1.28701170157209e-06 0.785611216248329 0.792682926829268 5.4 5 4 abnormal mesoderm development 1.27646856970639e-05 0.000178885384064487 0.785383172353917 0.792452830188679 5.4 5 4 increased circulating bilirubin level 1.27646856970639e-05 0.000178885384064487 0.785383172353917 0.792452830188679 5.4 5 4 atrioventricular septal defect 1.27646856970639e-05 0.000178885384064487 0.785383172353917 0.792452830188679 5.4 5 4 abnormal pulmonary alveolus morphology 1.69194469529132e-09 5.39578516607329e-08 0.785012883258041 0.792079207920792 5.4 5 4 small heart 3.46615983453228e-05 0.000427340939477749 0.784604022381344 0.791666666666667 5.4 5 4 abnormal digestive system morphology 0.00351774886494441 0.021552710102338 0.784604022381344 0.791666666666667 5.4 5 4 decreased metastatic potential 0.00351774886494441 0.021552710102338 0.784604022381344 0.791666666666667 5.4 5 4 abnormal retinal ganglion layer morphology 0.00351774886494441 0.021552710102338 0.784604022381344 0.791666666666667 5.4 5 4 anemia 3.193328530121e-18 3.61063850848909e-16 0.784408311724726 0.791469194312796 5.4 5 4 abnormal eye morphology 1.73227492967249e-12 8.79394670930676e-11 0.784306936420578 0.79136690647482 5.4 5 4 abnormal locomotor activation 1.2000554498053e-08 3.33534964401193e-07 0.784150231737977 0.791208791208791 5.4 5 4 rib fusion 1.03513867648404e-06 1.87265996927566e-05 0.783987679865726 0.791044776119403 5.4 5 4 premature death 3.43262537558854e-70 3.4154622487106e-67 0.78388459819064 0.790940766550523 5.4 5 4 abnormal axon guidance 9.45384509983612e-05 0.00103368965652054 0.78364367474073 0.790697674418605 5.4 5 4 delayed endochondral bone ossification 9.45384509983612e-05 0.00103368965652054 0.78364367474073 0.790697674418605 5.4 5 4 kidney failure 9.45384509983612e-05 0.00103368965652054 0.78364367474073 0.790697674418605 5.4 5 4 decreased erythrocyte cell number 8.86344012335834e-14 5.06846144985146e-12 0.782762846331505 0.789808917197452 5.4 5 4 decreased bone mineral density 2.75209233195485e-22 4.27864354733605e-20 0.782430604036797 0.789473684210526 5.4 5 4 abnormal reproductive system physiology 0.000259270011083676 0.0024522211124359 0.782430604036797 0.789473684210526 5.4 5 4 shiny skin 0.0100965978741625 0.0494882506639985 0.782430604036797 0.789473684210526 5.4 5 4 decreased grooming behavior 0.0100965978741625 0.0494882506639985 0.782430604036797 0.789473684210526 5.4 5 4 unresponsive to tactile stimuli 0.0100965978741625 0.0494882506639985 0.782430604036797 0.789473684210526 5.4 5 4 decreased tumor incidence 0.0100965978741625 0.0494882506639985 0.782430604036797 0.789473684210526 5.4 5 4 decreased germ cell number 0.0100965978741625 0.0494882506639985 0.782430604036797 0.789473684210526 5.4 5 4 abnormal response to novelty 0.0100965978741625 0.0494882506639985 0.782430604036797 0.789473684210526 5.4 5 4 increased left ventricle weight 0.0100965978741625 0.0494882506639985 0.782430604036797 0.789473684210526 5.4 5 4 decreased fertilization frequency 0.0100965978741625 0.0494882506639985 0.782430604036797 0.789473684210526 5.4 5 4 abnormal behavioral response to xenobiotic 0.0100965978741625 0.0494882506639985 0.782430604036797 0.789473684210526 5.4 5 4 increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 0.0100965978741625 0.0494882506639985 0.782430604036797 0.789473684210526 5.4 5 4 embryonic lethality between implantation and somite formation, incomplete penetrance 0.0100965978741625 0.0494882506639985 0.782430604036797 0.789473684210526 5.4 5 4 incomplete embryo turning 7.5090354224556e-06 0.000113204397656717 0.782430604036797 0.789473684210526 5.4 5 4 absent vitelline blood vessels 7.5090354224556e-06 0.000113204397656717 0.782430604036797 0.789473684210526 5.4 5 4 postnatal lethality 2.00616115862989e-14 1.27957073899791e-12 0.782116374878549 0.789156626506024 5.4 5 4 decreased cardiac muscle contractility 1.59816632885817e-09 5.12959837810929e-08 0.781427487877775 0.788461538461538 5.4 5 4 impaired swimming 1.64229898517668e-06 2.83695744835209e-05 0.780849936149854 0.787878787878788 5.4 5 4 enlarged pericardium 0.000716012636130562 0.0058205275567803 0.780849936149854 0.787878787878788 5.4 5 4 abnormal locomotor coordination 0.000716012636130562 0.0058205275567803 0.780849936149854 0.787878787878788 5.4 5 4 increased osteoblast cell number 0.000716012636130562 0.0058205275567803 0.780849936149854 0.787878787878788 5.4 5 4 decreased hematocrit 9.7948081269791e-13 5.07595525330427e-11 0.780644232794704 0.787671232876712 5.4 5 4 abnormal seminiferous tubule morphology 9.7948081269791e-13 5.07595525330427e-11 0.780644232794704 0.787671232876712 5.4 5 4 postnatal lethality, incomplete penetrance 3.02313430323198e-45 1.36728119623446e-42 0.779951070432455 0.786971830985915 5.4 5 4 prenatal lethality, incomplete penetrance 1.07797930003407e-24 2.3317160946389e-22 0.779170476519977 0.786184210526316 5.4 5 4 abnormal neuron differentiation 5.65329451655059e-10 1.96679302236638e-08 0.778704744017574 0.785714285714286 5.4 5 4 abnormal eye development 1.19004091690739e-05 0.000170127975908456 0.778704744017574 0.785714285714286 5.4 5 4 abnormal optic nerve morphology 0.000150314602044353 0.00150465823977999 0.778704744017574 0.785714285714286 5.4 5 4 shortened head 0.00199543646696514 0.0134376215235974 0.778704744017574 0.785714285714286 5.4 5 4 lymphoid hyperplasia 0.00199543646696514 0.0134376215235974 0.778704744017574 0.785714285714286 5.4 5 4 failure of blastocyst to hatch from the zona pellucida 0.00199543646696514 0.0134376215235974 0.778704744017574 0.785714285714286 5.4 5 4 enhanced coordination 0.00199543646696514 0.0134376215235974 0.778704744017574 0.785714285714286 5.4 5 4 abnormal vasoconstriction 0.0297730230122467 0.114202613327623 0.778704744017574 0.785714285714286 5.4 5 4 megacephaly 0.0297730230122467 0.114202613327623 0.778704744017574 0.785714285714286 5.4 5 4 translucent skin 0.0297730230122467 0.114202613327623 0.778704744017574 0.785714285714286 5.4 5 4 abnormal placing response 0.0297730230122467 0.114202613327623 0.778704744017574 0.785714285714286 5.4 5 4 absent otoliths 0.0297730230122467 0.114202613327623 0.778704744017574 0.785714285714286 5.4 5 4 abnormal sagittal suture morphology 0.0297730230122467 0.114202613327623 0.778704744017574 0.785714285714286 5.4 5 4 skeletal muscle necrosis 0.0297730230122467 0.114202613327623 0.778704744017574 0.785714285714286 5.4 5 4 abnormal pancreas development 0.0297730230122467 0.114202613327623 0.778704744017574 0.785714285714286 5.4 5 4 premature hair loss 0.0297730230122467 0.114202613327623 0.778704744017574 0.785714285714286 5.4 5 4 abnormal glucose tolerance 0.0297730230122467 0.114202613327623 0.778704744017574 0.785714285714286 5.4 5 4 decreased cornea thickness 0.0297730230122467 0.114202613327623 0.778704744017574 0.785714285714286 5.4 5 4 decreased tongue size 0.0297730230122467 0.114202613327623 0.778704744017574 0.785714285714286 5.4 5 4 sternebra fusion 0.0297730230122467 0.114202613327623 0.778704744017574 0.785714285714286 5.4 5 4 decreased compact bone area 0.0297730230122467 0.114202613327623 0.778704744017574 0.785714285714286 5.4 5 4 abnormal respiratory motile cilium physiology 0.0297730230122467 0.114202613327623 0.778704744017574 0.785714285714286 5.4 5 4 abnormal renal tubule epithelial cell primary cilium morphology 0.0297730230122467 0.114202613327623 0.778704744017574 0.785714285714286 5.4 5 4 abnormal vitelline vein topology 0.0297730230122467 0.114202613327623 0.778704744017574 0.785714285714286 5.4 5 4 hunched posture 2.13668593782809e-07 4.48523735894294e-06 0.777808651101559 0.784810126582278 5.4 5 4 abnormal nervous system morphology 2.13668593782809e-07 4.48523735894294e-06 0.777808651101559 0.784810126582278 5.4 5 4 distended abdomen 3.21663801310966e-05 0.000402071252349556 0.777316678520217 0.784313725490196 5.4 5 4 abnormal cervical vertebrae morphology 3.21663801310966e-05 0.000402071252349556 0.777316678520217 0.784313725490196 5.4 5 4 small kidney 4.73899534877905e-08 1.13896144252057e-06 0.777095849918364 0.784090909090909 5.4 5 4 increased erythroid progenitor cell number 0.000412031110009876 0.00365393007539953 0.776791464548243 0.783783783783784 5.4 5 4 abnormal respiratory electron transport chain 0.000412031110009876 0.00365393007539953 0.776791464548243 0.783783783783784 5.4 5 4 decreased bone mineral content 4.65447294399655e-17 4.82416727007976e-15 0.776662686122423 0.783653846153846 5.4 5 4 abnormal gait 1.49309346383633e-24 3.09505832607738e-22 0.776184663939847 0.783171521035599 5.4 5 4 abnormal forelimb morphology 8.72452798394938e-05 0.000960277139826287 0.775626859653868 0.782608695652174 5.4 5 4 abnormal carpal bone morphology 0.00563000061239185 0.0311907049517255 0.775626859653868 0.782608695652174 5.4 5 4 abnormal cranial nerve morphology 0.00563000061239185 0.0311907049517255 0.775626859653868 0.782608695652174 5.4 5 4 abnormal postnatal growth 0.00563000061239185 0.0311907049517255 0.775626859653868 0.782608695652174 5.4 5 4 abnormal Wolffian duct morphology 0.00563000061239185 0.0311907049517255 0.775626859653868 0.782608695652174 5.4 5 4 abnormal ulna morphology 0.00563000061239185 0.0311907049517255 0.775626859653868 0.782608695652174 5.4 5 4 absent gastric milk in neonates 3.3619596584801e-07 6.63720210354702e-06 0.775074418870639 0.782051282051282 5.4 5 4 short limbs 7.44710266790646e-08 1.73940543534435e-06 0.774636276180492 0.781609195402299 5.4 5 4 scoliosis 0.00113715906905962 0.00852013007314999 0.774280285244747 0.78125 5.4 5 4 failure of primitive streak formation 0.00113715906905962 0.00852013007314999 0.774280285244747 0.78125 5.4 5 4 increased circulating follicle stimulating hormone level 0.00113715906905962 0.00852013007314999 0.774280285244747 0.78125 5.4 5 4 pancreatic islet hyperplasia 0.00113715906905962 0.00852013007314999 0.774280285244747 0.78125 5.4 5 4 decreased body length 1.3152898904348e-21 1.98289915300398e-19 0.774054218008179 0.781021897810219 5.4 5 4 decreased leukocyte cell number 1.58018265952417e-11 7.27908215845624e-10 0.774054218008179 0.781021897810219 5.4 5 4 abnormal retina morphology 6.81068253455401e-17 6.77662912188124e-15 0.773985321326559 0.780952380952381 5.4 5 4 increased circulating HDL cholesterol level 3.69693388322333e-09 1.12147841884366e-07 0.773985321326559 0.780952380952381 5.4 5 4 seminiferous tubule degeneration 8.96895739055779e-07 1.64651524051753e-05 0.77385602207475 0.780821917808219 5.4 5 4 neonatal lethality, incomplete penetrance 1.53110996981893e-20 2.11590891662477e-18 0.773803805069212 0.780769230769231 5.4 5 4 Leydig cell hyperplasia 0.000237627832026811 0.00227783904495835 0.773524889844508 0.780487804878049 5.4 5 4 hemopericardium 0.000237627832026811 0.00227783904495835 0.773524889844508 0.780487804878049 5.4 5 4 short stride length 5.06953931389784e-05 0.000600499002062899 0.773041436788355 0.78 5.4 5 4 kidney inflammation 5.06953931389784e-05 0.000600499002062899 0.773041436788355 0.78 5.4 5 4 kyphosis 2.11224499035506e-12 1.05084188270164e-10 0.773041436788355 0.78 5.4 5 4 abnormal thoracic vertebrae morphology 1.09663471645187e-05 0.000158597607975234 0.772705477884927 0.779661016949153 5.4 5 4 impaired glucose tolerance 2.58307613425921e-19 3.29507788921528e-17 0.771283071237348 0.778225806451613 5.4 5 4 postnatal growth retardation 1.63070474911977e-45 8.11275612687086e-43 0.770839039532548 0.777777777777778 5.4 5 4 abnormal skeleton development 3.09940069961933e-07 6.14323445442476e-06 0.770839039532548 0.777777777777778 5.4 5 4 decreased heart weight 3.09940069961933e-07 6.14323445442476e-06 0.770839039532548 0.777777777777778 5.4 5 4 abnormal chondrocyte morphology 2.94889696654348e-05 0.000371411706545666 0.770839039532548 0.777777777777778 5.4 5 4 increased cell proliferation 2.94889696654348e-05 0.000371411706545666 0.770839039532548 0.777777777777778 5.4 5 4 abnormal mandible morphology 2.94889696654348e-05 0.000371411706545666 0.770839039532548 0.777777777777778 5.4 5 4 abnormal apoptosis 2.94889696654348e-05 0.000371411706545666 0.770839039532548 0.777777777777778 5.4 5 4 abnormal heart valve morphology 0.00316637077423959 0.0198147101909961 0.770839039532548 0.777777777777778 5.4 5 4 thin epidermis 0.00316637077423959 0.0198147101909961 0.770839039532548 0.777777777777778 5.4 5 4 abnormal fetal cardiomyocyte proliferation 0.00316637077423959 0.0198147101909961 0.770839039532548 0.777777777777778 5.4 5 4 abnormal skin appearance 0.00316637077423959 0.0198147101909961 0.770839039532548 0.777777777777778 5.4 5 4 skin lesions 6.4085285980375e-06 9.72025298025505e-05 0.770839039532548 0.777777777777778 5.4 5 4 increased circulating aspartate transaminase level 6.4085285980375e-06 9.72025298025505e-05 0.770839039532548 0.777777777777778 5.4 5 4 abnormal ovarian follicle morphology 0.000137318125202877 0.00142324515184232 0.770839039532548 0.777777777777778 5.4 5 4 abnormal ectoderm development 0.000137318125202877 0.00142324515184232 0.770839039532548 0.777777777777778 5.4 5 4 heart right ventricle hypertrophy 0.000650558280704464 0.00539421241084118 0.770839039532548 0.777777777777778 5.4 5 4 renal hypoplasia 0.000650558280704464 0.00539421241084118 0.770839039532548 0.777777777777778 5.4 5 4 abnormal lysosome morphology 0.000650558280704464 0.00539421241084118 0.770839039532548 0.777777777777778 5.4 5 4 narrow eye opening 0.000650558280704464 0.00539421241084118 0.770839039532548 0.777777777777778 5.4 5 4 abnormal retinal blood vessel morphology 0.000650558280704464 0.00539421241084118 0.770839039532548 0.777777777777778 5.4 5 4 underdeveloped hair follicles 0.0161666727915192 0.0695152957111566 0.770839039532548 0.777777777777778 5.4 5 4 abnormal phrenic nerve morphology 0.0161666727915192 0.0695152957111566 0.770839039532548 0.777777777777778 5.4 5 4 abnormal thymus cortex morphology 0.0161666727915192 0.0695152957111566 0.770839039532548 0.777777777777778 5.4 5 4 acidosis 0.0161666727915192 0.0695152957111566 0.770839039532548 0.777777777777778 5.4 5 4 abnormal metacarpal bone morphology 0.0161666727915192 0.0695152957111566 0.770839039532548 0.777777777777778 5.4 5 4 increased circulating renin level 0.0161666727915192 0.0695152957111566 0.770839039532548 0.777777777777778 5.4 5 4 increased circulating glycerol level 0.0161666727915192 0.0695152957111566 0.770839039532548 0.777777777777778 5.4 5 4 decreased activity of thyroid 0.0161666727915192 0.0695152957111566 0.770839039532548 0.777777777777778 5.4 5 4 absent inner cell mass 0.0161666727915192 0.0695152957111566 0.770839039532548 0.777777777777778 5.4 5 4 abnormal anterior eye segment morphology 0.0161666727915192 0.0695152957111566 0.770839039532548 0.777777777777778 5.4 5 4 abnormal eye anterior chamber morphology 0.0161666727915192 0.0695152957111566 0.770839039532548 0.777777777777778 5.4 5 4 abnormal pregnancy 0.0161666727915192 0.0695152957111566 0.770839039532548 0.777777777777778 5.4 5 4 primary atelectasis 0.0161666727915192 0.0695152957111566 0.770839039532548 0.777777777777778 5.4 5 4 abnormal aerobic respiration 0.0161666727915192 0.0695152957111566 0.770839039532548 0.777777777777778 5.4 5 4 abnormal head movements 0.0920395911426361 0.251896363839265 0.770839039532548 0.777777777777778 5.4 5 4 thick tail 0.0920395911426361 0.251896363839265 0.770839039532548 0.777777777777778 5.4 5 4 abnormal cholinergic neuron morphology 0.0920395911426361 0.251896363839265 0.770839039532548 0.777777777777778 5.4 5 4 abnormal lens vesicle development 0.0920395911426361 0.251896363839265 0.770839039532548 0.777777777777778 5.4 5 4 decreased level of surface class I molecules 0.0920395911426361 0.251896363839265 0.770839039532548 0.777777777777778 5.4 5 4 increased pheochromocytoma incidence 0.0920395911426361 0.251896363839265 0.770839039532548 0.777777777777778 5.4 5 4 abnormal posterior semicircular canal morphology 0.0920395911426361 0.251896363839265 0.770839039532548 0.777777777777778 5.4 5 4 genetic imprinting 0.0920395911426361 0.251896363839265 0.770839039532548 0.777777777777778 5.4 5 4 biliary cyst 0.0920395911426361 0.251896363839265 0.770839039532548 0.777777777777778 5.4 5 4 abnormal ovary physiology 0.0920395911426361 0.251896363839265 0.770839039532548 0.777777777777778 5.4 5 4 impaired febrile response 0.0920395911426361 0.251896363839265 0.770839039532548 0.777777777777778 5.4 5 4 decreased vestibular hair cell number 0.0920395911426361 0.251896363839265 0.770839039532548 0.777777777777778 5.4 5 4 decreased cochlear hair cell number 0.0920395911426361 0.251896363839265 0.770839039532548 0.777777777777778 5.4 5 4 abnormal intervertebral disk development 0.0920395911426361 0.251896363839265 0.770839039532548 0.777777777777778 5.4 5 4 absent adrenal gland 0.0920395911426361 0.251896363839265 0.770839039532548 0.777777777777778 5.4 5 4 abnormal inguinal fat pad morphology 0.0920395911426361 0.251896363839265 0.770839039532548 0.777777777777778 5.4 5 4 abnormal leukopoiesis 0.0920395911426361 0.251896363839265 0.770839039532548 0.777777777777778 5.4 5 4 abnormal optic chiasm morphology 0.0920395911426361 0.251896363839265 0.770839039532548 0.777777777777778 5.4 5 4 abnormal retinal development 0.0920395911426361 0.251896363839265 0.770839039532548 0.777777777777778 5.4 5 4 multiflagellated sperm 0.0920395911426361 0.251896363839265 0.770839039532548 0.777777777777778 5.4 5 4 eye opacity 0.0920395911426361 0.251896363839265 0.770839039532548 0.777777777777778 5.4 5 4 abnormal cerebellar layer morphology 0.0920395911426361 0.251896363839265 0.770839039532548 0.777777777777778 5.4 5 4 axonal spheroids 0.0920395911426361 0.251896363839265 0.770839039532548 0.777777777777778 5.4 5 4 prolonged RR interval 0.0920395911426361 0.251896363839265 0.770839039532548 0.777777777777778 5.4 5 4 shortened ST segment 0.0920395911426361 0.251896363839265 0.770839039532548 0.777777777777778 5.4 5 4 abnormal heart left ventricle pressure 0.0920395911426361 0.251896363839265 0.770839039532548 0.777777777777778 5.4 5 4 abnormal pulmonary alveolar parenchyma morphology 0.0920395911426361 0.251896363839265 0.770839039532548 0.777777777777778 5.4 5 4 abnormal lung lobe morphology 0.0920395911426361 0.251896363839265 0.770839039532548 0.777777777777778 5.4 5 4 abnormal ureteric bud invasion 0.0920395911426361 0.251896363839265 0.770839039532548 0.777777777777778 5.4 5 4 increased core body temperature 0.0920395911426361 0.251896363839265 0.770839039532548 0.777777777777778 5.4 5 4 decreased bone trabecular spacing 0.0920395911426361 0.251896363839265 0.770839039532548 0.777777777777778 5.4 5 4 increased myeloid cell number 0.0920395911426361 0.251896363839265 0.770839039532548 0.777777777777778 5.4 5 4 trigeminal neuroma 0.0920395911426361 0.251896363839265 0.770839039532548 0.777777777777778 5.4 5 4 abnormal infrahyoid muscle connection 0.0920395911426361 0.251896363839265 0.770839039532548 0.777777777777778 5.4 5 4 abnormal coronary sinus connection 0.0920395911426361 0.251896363839265 0.770839039532548 0.777777777777778 5.4 5 4 increased cardiac muscle glycogen level 0.0920395911426361 0.251896363839265 0.770839039532548 0.777777777777778 5.4 5 4 decreased bone mineral density of femur 0.0920395911426361 0.251896363839265 0.770839039532548 0.777777777777778 5.4 5 4 enhanced leukocyte tethering or rolling 0.0920395911426361 0.251896363839265 0.770839039532548 0.777777777777778 5.4 5 4 decreased platelet dense granule number 0.0920395911426361 0.251896363839265 0.770839039532548 0.777777777777778 5.4 5 4 abnormal coat/hair pigmentation 2.0181677709109e-09 6.31470733351051e-08 0.76985582647192 0.776785714285714 5.4 5 4 neonatal lethality, complete penetrance 7.52078055283516e-34 2.67256308931106e-31 0.769390093969517 0.776315789473684 5.4 5 4 decreased white adipose tissue amount 3.7471213886445e-06 6.05257432094364e-05 0.769195459490901 0.776119402985075 5.4 5 4 cardiac hypertrophy 2.38469128423455e-08 6.08402007131634e-07 0.768591695393969 0.775510204081633 5.4 5 4 abnormal long bone hypertrophic chondrocyte zone 7.94935339372493e-05 0.000878845180750701 0.768591695393969 0.775510204081633 5.4 5 4 increased T cell derived lymphoma incidence 7.94935339372493e-05 0.000878845180750701 0.768591695393969 0.775510204081633 5.4 5 4 abnormal craniofacial development 7.94935339372493e-05 0.000878845180750701 0.768591695393969 0.775510204081633 5.4 5 4 abnormal muscle physiology 1.07151437500264e-07 2.41211946408966e-06 0.768364435874338 0.775280898876405 5.4 5 4 abnormal ovary morphology 2.19216242805498e-06 3.65973425489044e-05 0.767737071566622 0.774647887323944 5.4 5 4 corneal opacity 2.19216242805498e-06 3.65973425489044e-05 0.767737071566622 0.774647887323944 5.4 5 4 decreased liver weight 2.19216242805498e-06 3.65973425489044e-05 0.767737071566622 0.774647887323944 5.4 5 4 decreased body weight 1.27601995655032e-89 2.11606642794595e-86 0.767725796238798 0.774636510500808 5.4 5 4 prenatal lethality 1.00074071308045e-05 0.000147298374188616 0.767286785894149 0.774193548387097 5.4 5 4 decreased thymus weight 0.00179257037118726 0.0122552246017582 0.767286785894149 0.774193548387097 5.4 5 4 pale kidney 0.00179257037118726 0.0122552246017582 0.767286785894149 0.774193548387097 5.4 5 4 decreased double-negative T cell number 0.00179257037118726 0.0122552246017582 0.767286785894149 0.774193548387097 5.4 5 4 preaxial polydactyly 0.00179257037118726 0.0122552246017582 0.767286785894149 0.774193548387097 5.4 5 4 decreased circulating HDL cholesterol level 2.45367803670476e-10 9.31835742947035e-09 0.766537482392299 0.7734375 5.4 5 4 abnormal myocardial fiber morphology 3.70642441052524e-08 9.2660610263131e-07 0.766298014262842 0.77319587628866 5.4 5 4 muscular atrophy 0.000214913759540301 0.00207845677587793 0.765833591223895 0.772727272727273 5.4 5 4 intestinal inflammation 0.00892243996946198 0.0444043907806705 0.765833591223895 0.772727272727273 5.4 5 4 increased coping response 0.00892243996946198 0.0444043907806705 0.765833591223895 0.772727272727273 5.4 5 4 abnormal tracheal cartilage morphology 0.00892243996946198 0.0444043907806705 0.765833591223895 0.772727272727273 5.4 5 4 decreased cardiac output 0.00892243996946198 0.0444043907806705 0.765833591223895 0.772727272727273 5.4 5 4 abnormal basement membrane morphology 0.00892243996946198 0.0444043907806705 0.765833591223895 0.772727272727273 5.4 5 4 failure of palatal shelf elevation 0.00892243996946198 0.0444043907806705 0.765833591223895 0.772727272727273 5.4 5 4 increased circulating creatine kinase level 0.00892243996946198 0.0444043907806705 0.765833591223895 0.772727272727273 5.4 5 4 abnormal blood vessel morphology 1.92637544574603e-11 8.71247076598771e-10 0.765522908225427 0.772413793103448 5.4 5 4 increased blood urea nitrogen level 1.92637544574603e-11 8.71247076598771e-10 0.765522908225427 0.772413793103448 5.4 5 4 abnormal embryo development 8.55185883721132e-11 3.63636732607917e-09 0.765171105418338 0.772058823529412 5.4 5 4 hypoactivity 2.53537707337111e-27 7.41970643530664e-25 0.76499713699725 0.771883289124668 5.4 5 4 abnormal action potential 3.40792564478897e-06 5.52261566215802e-05 0.764546475944527 0.771428571428571 5.4 5 4 ovary cysts 0.001020139148793 0.00777367409278748 0.764546475944527 0.771428571428571 5.4 5 4 holoprosencephaly 0.001020139148793 0.00777367409278748 0.764546475944527 0.771428571428571 5.4 5 4 decreased triglyceride level 0.001020139148793 0.00777367409278748 0.764546475944527 0.771428571428571 5.4 5 4 impaired behavioral response to xenobiotic 0.001020139148793 0.00777367409278748 0.764546475944527 0.771428571428571 5.4 5 4 decreased bone mineralization 0.001020139148793 0.00777367409278748 0.764546475944527 0.771428571428571 5.4 5 4 cyanosis 1.60278354104319e-14 1.04919054166972e-12 0.76395654810815 0.770833333333333 5.4 5 4 decreased circulating cholesterol level 7.08325757241223e-14 4.19514362175606e-12 0.763618064923344 0.770491803278688 5.4 5 4 decreased heart rate 3.37482574623807e-08 8.47967580178504e-07 0.763130649137223 0.77 5.4 5 4 perinatal lethality, incomplete penetrance 1.00470672680361e-16 9.25632586268137e-15 0.763042943051814 0.769911504424779 5.4 5 4 eyelids open at birth 7.16858334276499e-05 0.000805049709486588 0.762368280856366 0.769230769230769 5.4 5 4 decreased kidney weight 7.16858334276499e-05 0.000805049709486588 0.762368280856366 0.769230769230769 5.4 5 4 abnormal female meiosis 7.16858334276499e-05 0.000805049709486588 0.762368280856366 0.769230769230769 5.4 5 4 abnormal xiphoid process morphology 0.00498038548739148 0.0278397952806434 0.762368280856366 0.769230769230769 5.4 5 4 heart inflammation 0.00498038548739148 0.0278397952806434 0.762368280856366 0.769230769230769 5.4 5 4 abnormal erythrocyte osmotic lysis 0.00498038548739148 0.0278397952806434 0.762368280856366 0.769230769230769 5.4 5 4 abnormal Mullerian duct morphology 0.00498038548739148 0.0278397952806434 0.762368280856366 0.769230769230769 5.4 5 4 pulmonary edema 0.00498038548739148 0.0278397952806434 0.762368280856366 0.769230769230769 5.4 5 4 decreased bone resorption 0.00498038548739148 0.0278397952806434 0.762368280856366 0.769230769230769 5.4 5 4 absent common myeloid progenitor cells 0.0476965760487669 0.160007057210125 0.762368280856366 0.769230769230769 5.4 5 4 small trigeminal ganglion 0.0476965760487669 0.160007057210125 0.762368280856366 0.769230769230769 5.4 5 4 tight skin 0.0476965760487669 0.160007057210125 0.762368280856366 0.769230769230769 5.4 5 4 anal atresia 0.0476965760487669 0.160007057210125 0.762368280856366 0.769230769230769 5.4 5 4 abnormal GABAergic neuron morphology 0.0476965760487669 0.160007057210125 0.762368280856366 0.769230769230769 5.4 5 4 vestibular hair cell degeneration 0.0476965760487669 0.160007057210125 0.762368280856366 0.769230769230769 5.4 5 4 small interparietal bone 0.0476965760487669 0.160007057210125 0.762368280856366 0.769230769230769 5.4 5 4 decreased endocochlear potential 0.0476965760487669 0.160007057210125 0.762368280856366 0.769230769230769 5.4 5 4 abnormal exocrine pancreas morphology 0.0476965760487669 0.160007057210125 0.762368280856366 0.769230769230769 5.4 5 4 increased circulating ammonia level 0.0476965760487669 0.160007057210125 0.762368280856366 0.769230769230769 5.4 5 4 hyperalgesia 0.0476965760487669 0.160007057210125 0.762368280856366 0.769230769230769 5.4 5 4 empty decidua capsularis 0.0476965760487669 0.160007057210125 0.762368280856366 0.769230769230769 5.4 5 4 increased prostaglandin level 0.0476965760487669 0.160007057210125 0.762368280856366 0.769230769230769 5.4 5 4 abnormal heart ventricle morphology 1.1639689908413e-06 2.0607636047813e-05 0.762368280856366 0.769230769230769 5.4 5 4 abnormal bone mineralization 1.53923030963055e-09 4.97251350026753e-08 0.761738224425907 0.768595041322314 5.4 5 4 decreased birth weight 8.87647139597244e-08 2.02570849518178e-06 0.761565787929149 0.768421052631579 5.4 5 4 short mandible 4.15199353927178e-05 0.000498941252605727 0.761006908926266 0.767857142857143 5.4 5 4 abnormal organ of Corti morphology 0.000334375900496125 0.00301362337856562 0.760595331366003 0.767441860465116 5.4 5 4 abnormal left-right axis patterning 0.000334375900496125 0.00301362337856562 0.760595331366003 0.767441860465116 5.4 5 4 abnormal blood circulation 0.000334375900496125 0.00301362337856562 0.760595331366003 0.767441860465116 5.4 5 4 oxidative stress 2.33403360139598e-07 4.85850090667155e-06 0.759827053253512 0.766666666666667 5.4 5 4 abnormal eating behavior 2.40864617011522e-05 0.000308046650291085 0.759827053253512 0.766666666666667 5.4 5 4 delayed eyelid opening 0.00280331520982545 0.0176985953919817 0.759827053253512 0.766666666666667 5.4 5 4 abnormal lactation 0.00280331520982545 0.0176985953919817 0.759827053253512 0.766666666666667 5.4 5 4 abnormal cellular respiration 0.00280331520982545 0.0176985953919817 0.759827053253512 0.766666666666667 5.4 5 4 reduced male fertility 2.16701845724371e-16 1.92516371871204e-14 0.759681520395199 0.766519823788546 5.4 5 4 decreased hemoglobin content 1.08989500310586e-10 4.48117986814187e-09 0.759124160512297 0.765957446808511 5.4 5 4 cleft secondary palate 1.36755782562873e-07 3.00746304766186e-06 0.759124160512297 0.765957446808511 5.4 5 4 increased respiratory quotient 0.000192338623137706 0.00187624441198056 0.759124160512297 0.765957446808511 5.4 5 4 abnormal osteoclast physiology 1.39927338589923e-05 0.000192395962613039 0.758794679539852 0.765625 5.4 5 4 polydactyly 8.01642373538647e-08 1.86224316542531e-06 0.758478646770364 0.76530612244898 5.4 5 4 cochlear inner hair cell degeneration 0.000110914685414593 0.00117155108267006 0.757883761557211 0.764705882352941 5.4 5 4 abnormal lung morphology 3.64121992892349e-09 1.11135393536162e-07 0.757883761557211 0.764705882352941 5.4 5 4 short maxilla 0.00158808715699497 0.0110965359635534 0.757883761557211 0.764705882352941 5.4 5 4 abnormal oocyte morphology 0.00158808715699497 0.0110965359635534 0.757883761557211 0.764705882352941 5.4 5 4 abnormal endoderm development 0.00158808715699497 0.0110965359635534 0.757883761557211 0.764705882352941 5.4 5 4 hydroureter 0.0255690791940989 0.101278796967072 0.757883761557211 0.764705882352941 5.4 5 4 distended urinary bladder 0.0255690791940989 0.101278796967072 0.757883761557211 0.764705882352941 5.4 5 4 abnormal ectoplacental cone morphology 0.0255690791940989 0.101278796967072 0.757883761557211 0.764705882352941 5.4 5 4 abnormal electroretinogram waveform feature 0.0255690791940989 0.101278796967072 0.757883761557211 0.764705882352941 5.4 5 4 abnormal cell cytoskeleton morphology 0.0255690791940989 0.101278796967072 0.757883761557211 0.764705882352941 5.4 5 4 postnatal lethality, complete penetrance 2.11251789500633e-26 5.25488826382824e-24 0.757430662457037 0.764248704663212 5.4 5 4 extramedullary hematopoiesis 2.7579144562367e-08 6.96478396943024e-07 0.757333773341277 0.764150943396226 5.4 5 4 abnormal neuromuscular synapse morphology 4.73958649088671e-06 7.34562080752692e-05 0.757074056683753 0.763888888888889 5.4 5 4 abnormal rostral-caudal axis patterning 6.40989050628676e-05 0.000733774268434128 0.75682378426832 0.763636363636364 5.4 5 4 decreased total body fat amount 6.63920439262788e-23 1.06548522107496e-20 0.756661931448759 0.763473053892216 5.4 5 4 hypoglycemia 2.10048698637011e-07 4.446775641358e-06 0.756630024978953 0.763440860215054 5.4 5 4 lethargy 2.10048698637011e-07 4.446775641358e-06 0.756630024978953 0.763440860215054 5.4 5 4 decreased birth body size 9.50170173953665e-09 2.71672219276982e-07 0.756349583902237 0.763157894736842 5.4 5 4 abnormal axial skeleton morphology 2.76274617170563e-06 4.50644662433952e-05 0.756349583902237 0.763157894736842 5.4 5 4 decreased hair follicle number 0.000904261317660968 0.00707342776000522 0.756349583902237 0.763157894736842 5.4 5 4 increased hemoglobin content 3.71131534249255e-05 0.000449240725764001 0.755907532713516 0.76271186440678 5.4 5 4 increased heart weight 2.56034293678197e-10 9.64977735643203e-09 0.755786684187103 0.762589928057554 5.4 5 4 abnormal retinal pigment epithelium morphology 1.61189222597044e-06 2.79413373665608e-05 0.755697558398873 0.7625 5.4 5 4 abnormal cartilage morphology 0.000517030167970672 0.00434497480684813 0.755107630562496 0.761904761904762 5.4 5 4 small ears 0.0139895316060009 0.0636178425410006 0.755107630562496 0.761904761904762 5.4 5 4 abnormal salivary gland morphology 0.0139895316060009 0.0636178425410006 0.755107630562496 0.761904761904762 5.4 5 4 trunk curl 0.0139895316060009 0.0636178425410006 0.755107630562496 0.761904761904762 5.4 5 4 abnormal erythrocyte physiology 0.0139895316060009 0.0636178425410006 0.755107630562496 0.761904761904762 5.4 5 4 decreased cochlear outer hair cell number 0.0139895316060009 0.0636178425410006 0.755107630562496 0.761904761904762 5.4 5 4 abnormal clavicle morphology 0.0139895316060009 0.0636178425410006 0.755107630562496 0.761904761904762 5.4 5 4 complete atrioventricular septal defect 0.0139895316060009 0.0636178425410006 0.755107630562496 0.761904761904762 5.4 5 4 vascular ring 0.0139895316060009 0.0636178425410006 0.755107630562496 0.761904761904762 5.4 5 4 embryonic lethality at implantation, complete penetrance 0.0139895316060009 0.0636178425410006 0.755107630562496 0.761904761904762 5.4 5 4 abnormal vertebrae morphology 2.4773604836461e-08 6.28819816639764e-07 0.754674656003687 0.761467889908257 5.4 5 4 increased total body fat amount 6.65290007496792e-10 2.28263295675623e-08 0.754403239116076 0.761194029850746 5.4 5 4 abnormal sleep pattern 0.000296640814995457 0.00269304389525985 0.754081669107928 0.760869565217391 5.4 5 4 retinal degeneration 1.88178472212544e-07 4.01797381655539e-06 0.753632810971554 0.760416666666667 5.4 5 4 decreased double-positive T cell number 1.10167271013541e-07 2.45776759323932e-06 0.75321986148609 0.76 5.4 5 4 abnormal hindlimb morphology 0.000170687646465108 0.00169157577921098 0.75321986148609 0.76 5.4 5 4 ruffled hair 0.00775969868695687 0.0400461628294714 0.75321986148609 0.76 5.4 5 4 abnormal primitive streak morphology 0.00775969868695687 0.0400461628294714 0.75321986148609 0.76 5.4 5 4 diaphragmatic hernia 0.00775969868695687 0.0400461628294714 0.75321986148609 0.76 5.4 5 4 impaired conditioned place preference behavior 0.00775969868695687 0.0400461628294714 0.75321986148609 0.76 5.4 5 4 abnormal neurocranium morphology 4.2325092558068e-06 6.68467731671073e-05 0.75321986148609 0.76 5.4 5 4 spleen hyperplasia 4.2325092558068e-06 6.68467731671073e-05 0.75321986148609 0.76 5.4 5 4 abnormal somite development 2.46673122836796e-06 4.07707237911316e-05 0.752718049453121 0.759493670886076 5.4 5 4 abnormal placenta morphology 2.46673122836796e-06 4.07707237911316e-05 0.752718049453121 0.759493670886076 5.4 5 4 abnormal cardiovascular system physiology 1.01465121649551e-09 3.38784550474172e-08 0.752623723883014 0.759398496240602 5.4 5 4 short snout 3.78157016055504e-08 9.40413247845074e-07 0.752485729067488 0.759259259259259 5.4 5 4 decreased tumor growth/size 9.84563469620783e-05 0.00106021715613926 0.752485729067488 0.759259259259259 5.4 5 4 short tail 1.43895467086745e-06 2.51185946932125e-05 0.752264604845017 0.759036144578313 5.4 5 4 abnormal retinal pigmentation 8.40107331704691e-07 1.5537301023163e-05 0.75185285629283 0.758620689655172 5.4 5 4 cochlear ganglion degeneration 5.69124656299824e-05 0.000670946721585694 0.75185285629283 0.758620689655172 5.4 5 4 abnormal microglial cell morphology 0.00434683947698277 0.0246304400888261 0.75185285629283 0.758620689655172 5.4 5 4 aphagia 0.00434683947698277 0.0246304400888261 0.75185285629283 0.758620689655172 5.4 5 4 decreased trophoblast giant cell number 0.00434683947698277 0.0246304400888261 0.75185285629283 0.758620689655172 5.4 5 4 abnormal embryonic erythropoiesis 0.00434683947698277 0.0246304400888261 0.75185285629283 0.758620689655172 5.4 5 4 increased thermal nociceptive threshold 4.90852135145531e-07 9.32057012346953e-06 0.751477305415561 0.758241758241758 5.4 5 4 belly spot 0.00245324167196291 0.0155873273537873 0.750817246297937 0.757575757575758 5.4 5 4 dextrocardia 0.00245324167196291 0.0155873273537873 0.750817246297937 0.757575757575758 5.4 5 4 abnormal ovarian folliculogenesis 0.00245324167196291 0.0155873273537873 0.750817246297937 0.757575757575758 5.4 5 4 abnormal skeleton physiology 0.00245324167196291 0.0155873273537873 0.750817246297937 0.757575757575758 5.4 5 4 abnormal QRS complex 0.00245324167196291 0.0155873273537873 0.750817246297937 0.757575757575758 5.4 5 4 abnormal middle ear ossicle morphology 0.00245324167196291 0.0155873273537873 0.750817246297937 0.757575757575758 5.4 5 4 abnormal branching of the mammary ductal tree 0.00139264281175429 0.00992607161673008 0.750005551977614 0.756756756756757 5.4 5 4 increased circulating phosphate level 0.00139264281175429 0.00992607161673008 0.750005551977614 0.756756756756757 5.4 5 4 abnormal testis morphology 1.97729529827699e-08 5.15028487378432e-07 0.749772630998739 0.756521739130435 5.4 5 4 liver fibrosis 0.000794280348566226 0.00636987123434217 0.749352237036867 0.75609756097561 5.4 5 4 increased oxygen consumption 1.27885639672293e-06 2.24816628045815e-05 0.749071159678639 0.755813953488372 5.4 5 4 decreased insulin secretion 7.46692803483773e-07 1.38611817064618e-05 0.748815066974475 0.755555555555556 5.4 5 4 abnormal autopod morphology 0.000454754811128706 0.00400425696524834 0.748815066974475 0.755555555555556 5.4 5 4 increased insulin sensitivity 4.74993075725198e-10 1.68792182266633e-08 0.748507039386251 0.755244755244755 5.4 5 4 organ of Corti degeneration 0.000261200525401351 0.00246579243618922 0.74836559814676 0.755102040816326 5.4 5 4 kinked tail 1.49255540903112e-07 3.24256033184709e-06 0.748167303075709 0.754901960784314 5.4 5 4 abnormal extraembryonic tissue morphology 1.49255540903112e-07 3.24256033184709e-06 0.748167303075709 0.754901960784314 5.4 5 4 increased body weight 7.78311055674069e-15 5.37791319719236e-13 0.747733532607784 0.754464285714286 5.4 5 4 abnormal kidney morphology 6.79093853241789e-12 3.24854992295952e-10 0.747556554256871 0.754285714285714 5.4 5 4 increased lymphocyte cell number 1.68930340060754e-05 0.000223518202606982 0.746899938925947 0.753623188405797 5.4 5 4 abnormal food intake 1.68930340060754e-05 0.000223518202606982 0.746899938925947 0.753623188405797 5.4 5 4 decreased percent body fat/body weight 9.81727720527976e-06 0.000144928647169931 0.746703179194934 0.753424657534247 5.4 5 4 perinatal lethality, complete penetrance 7.71706238242149e-14 4.46423085494732e-12 0.744472311822179 0.751173708920188 5.4 5 4 increased or absent threshold for auditory brainstem response 3.29409835804574e-18 3.6418087402839e-16 0.744166408406854 0.750865051903114 5.4 5 4 abnormal heart left ventricle morphology 1.48602875073513e-05 0.000200742883293744 0.743309073834957 0.75 5.4 5 4 cochlear outer hair cell degeneration 1.48602875073513e-05 0.000200742883293744 0.743309073834957 0.75 5.4 5 4 abnormal incisor morphology 7.61932285962452e-05 0.000853741694293513 0.743309073834957 0.75 5.4 5 4 hypertension 0.000692762323363594 0.00569654692603858 0.743309073834957 0.75 5.4 5 4 head bobbing 0.00121189745836635 0.00905283762067955 0.743309073834957 0.75 5.4 5 4 abnormal uterus morphology 0.00212888175305863 0.0140466667393458 0.743309073834957 0.75 5.4 5 4 abnormal trophoblast giant cell morphology 0.00212888175305863 0.0140466667393458 0.743309073834957 0.75 5.4 5 4 small superior cervical ganglion 0.00667917369606293 0.0354541557797759 0.743309073834957 0.75 5.4 5 4 abnormal retinal inner nuclear layer morphology 0.00667917369606293 0.0354541557797759 0.743309073834957 0.75 5.4 5 4 abnormal hormone level 0.00667917369606293 0.0354541557797759 0.743309073834957 0.75 5.4 5 4 abnormal malleus morphology 0.0119667558547342 0.0555878715007494 0.743309073834957 0.75 5.4 5 4 abnormal foregut morphology 0.0119667558547342 0.0555878715007494 0.743309073834957 0.75 5.4 5 4 abnormal vasodilation 0.0119667558547342 0.0555878715007494 0.743309073834957 0.75 5.4 5 4 apnea 0.0119667558547342 0.0555878715007494 0.743309073834957 0.75 5.4 5 4 prolonged QT interval 0.0119667558547342 0.0555878715007494 0.743309073834957 0.75 5.4 5 4 decreased ovulation rate 0.0119667558547342 0.0555878715007494 0.743309073834957 0.75 5.4 5 4 abnormal tumor morphology 0.0119667558547342 0.0555878715007494 0.743309073834957 0.75 5.4 5 4 abnormal inner cell mass apoptosis 0.0119667558547342 0.0555878715007494 0.743309073834957 0.75 5.4 5 4 abnormal pericardium morphology 0.0216783831711308 0.0869757711906254 0.743309073834957 0.75 5.4 5 4 small gonad 0.0216783831711308 0.0869757711906254 0.743309073834957 0.75 5.4 5 4 abnormal hearing physiology 0.0216783831711308 0.0869757711906254 0.743309073834957 0.75 5.4 5 4 abnormal male reproductive system physiology 0.0216783831711308 0.0869757711906254 0.743309073834957 0.75 5.4 5 4 abnormal physiological neovascularization 0.0216783831711308 0.0869757711906254 0.743309073834957 0.75 5.4 5 4 kidney atrophy 0.0216783831711308 0.0869757711906254 0.743309073834957 0.75 5.4 5 4 abnormal induced retinal neovascularization 0.0216783831711308 0.0869757711906254 0.743309073834957 0.75 5.4 5 4 decreased digestive secretion 0.0751522560435921 0.214014009053733 0.743309073834957 0.75 5.4 5 4 impaired embryo implantation 0.0751522560435921 0.214014009053733 0.743309073834957 0.75 5.4 5 4 ear inflammation 0.0751522560435921 0.214014009053733 0.743309073834957 0.75 5.4 5 4 increased growth rate 0.0751522560435921 0.214014009053733 0.743309073834957 0.75 5.4 5 4 increased circulating parathyroid hormone level 0.0751522560435921 0.214014009053733 0.743309073834957 0.75 5.4 5 4 small thyroid gland 0.0751522560435921 0.214014009053733 0.743309073834957 0.75 5.4 5 4 abnormal aorta elastic fiber morphology 0.0751522560435921 0.214014009053733 0.743309073834957 0.75 5.4 5 4 abnormal alisphenoid bone morphology 0.0751522560435921 0.214014009053733 0.743309073834957 0.75 5.4 5 4 small intestinal inflammation 0.0751522560435921 0.214014009053733 0.743309073834957 0.75 5.4 5 4 increased fear-related response 0.0751522560435921 0.214014009053733 0.743309073834957 0.75 5.4 5 4 decreased left ventricle systolic pressure 0.0751522560435921 0.214014009053733 0.743309073834957 0.75 5.4 5 4 abnormal defecation 0.0751522560435921 0.214014009053733 0.743309073834957 0.75 5.4 5 4 pale placenta 0.0751522560435921 0.214014009053733 0.743309073834957 0.75 5.4 5 4 decreased cochlear nerve compound action potential 0.0751522560435921 0.214014009053733 0.743309073834957 0.75 5.4 5 4 abnormal palatine bone morphology 0.0751522560435921 0.214014009053733 0.743309073834957 0.75 5.4 5 4 hemoperitoneum 0.0751522560435921 0.214014009053733 0.743309073834957 0.75 5.4 5 4 decreased renal glomerular filtration rate 0.0751522560435921 0.214014009053733 0.743309073834957 0.75 5.4 5 4 abnormal thymus corticomedullary boundary morphology 0.0751522560435921 0.214014009053733 0.743309073834957 0.75 5.4 5 4 abnormal behavioral response to addictive substance 0.0751522560435921 0.214014009053733 0.743309073834957 0.75 5.4 5 4 decreased prostaglandin level 0.0751522560435921 0.214014009053733 0.743309073834957 0.75 5.4 5 4 abnormal colon goblet cell morphology 0.0751522560435921 0.214014009053733 0.743309073834957 0.75 5.4 5 4 failure of tooth eruption 0.0398879966995042 0.13582668280632 0.743309073834957 0.75 5.4 5 4 abnormal bone marrow cell number 0.0398879966995042 0.13582668280632 0.743309073834957 0.75 5.4 5 4 vasculature congestion 0.0398879966995042 0.13582668280632 0.743309073834957 0.75 5.4 5 4 decreased mast cell number 0.0398879966995042 0.13582668280632 0.743309073834957 0.75 5.4 5 4 abnormal hair follicle orientation 0.0398879966995042 0.13582668280632 0.743309073834957 0.75 5.4 5 4 abnormal olfaction 0.0398879966995042 0.13582668280632 0.743309073834957 0.75 5.4 5 4 abnormal epicardium morphology 0.0398879966995042 0.13582668280632 0.743309073834957 0.75 5.4 5 4 abnormal pulmonary elastic fiber morphology 0.0398879966995042 0.13582668280632 0.743309073834957 0.75 5.4 5 4 small pancreas 0.0398879966995042 0.13582668280632 0.743309073834957 0.75 5.4 5 4 bowed tibia 0.0398879966995042 0.13582668280632 0.743309073834957 0.75 5.4 5 4 small epididymis 0.0398879966995042 0.13582668280632 0.743309073834957 0.75 5.4 5 4 blepharitis 0.0398879966995042 0.13582668280632 0.743309073834957 0.75 5.4 5 4 decreased circulating triiodothyronine level 0.0398879966995042 0.13582668280632 0.743309073834957 0.75 5.4 5 4 impaired behavioral response to addictive substance 0.0398879966995042 0.13582668280632 0.743309073834957 0.75 5.4 5 4 decreased skeletal muscle weight 0.0398879966995042 0.13582668280632 0.743309073834957 0.75 5.4 5 4 dilated respiratory conducting tubes 0.0398879966995042 0.13582668280632 0.743309073834957 0.75 5.4 5 4 abnormal pulmonary alveolus wall morphology 0.0398879966995042 0.13582668280632 0.743309073834957 0.75 5.4 5 4 embryonic lethality between somite formation and embryo turning, incomplete penetrance 0.0398879966995042 0.13582668280632 0.743309073834957 0.75 5.4 5 4 schistocytosis 0.147462324382762 0.330164295141423 0.743309073834957 0.75 5.4 5 4 pointed snout 0.147462324382762 0.330164295141423 0.743309073834957 0.75 5.4 5 4 clubfoot 0.147462324382762 0.330164295141423 0.743309073834957 0.75 5.4 5 4 abnormal hypoglossal nerve morphology 0.147462324382762 0.330164295141423 0.743309073834957 0.75 5.4 5 4 abnormal vagus ganglion morphology 0.147462324382762 0.330164295141423 0.743309073834957 0.75 5.4 5 4 dermal cysts 0.147462324382762 0.330164295141423 0.743309073834957 0.75 5.4 5 4 abnormal pupil morphology 0.147462324382762 0.330164295141423 0.743309073834957 0.75 5.4 5 4 abnormal erythrocyte cell number 0.147462324382762 0.330164295141423 0.743309073834957 0.75 5.4 5 4 abnormal urination 0.147462324382762 0.330164295141423 0.743309073834957 0.75 5.4 5 4 abnormal atrial thrombosis 0.147462324382762 0.330164295141423 0.743309073834957 0.75 5.4 5 4 coarse hair 0.147462324382762 0.330164295141423 0.743309073834957 0.75 5.4 5 4 abnormal thyroid physiology 0.147462324382762 0.330164295141423 0.743309073834957 0.75 5.4 5 4 decreased susceptibility to age related obesity 0.147462324382762 0.330164295141423 0.743309073834957 0.75 5.4 5 4 abnormal umbilical artery morphology 0.147462324382762 0.330164295141423 0.743309073834957 0.75 5.4 5 4 abnormal perineum morphology 0.147462324382762 0.330164295141423 0.743309073834957 0.75 5.4 5 4 increased cardiac output 0.147462324382762 0.330164295141423 0.743309073834957 0.75 5.4 5 4 pulmonary interstitial fibrosis 0.147462324382762 0.330164295141423 0.743309073834957 0.75 5.4 5 4 abnormal forelimb zeugopod morphology 0.147462324382762 0.330164295141423 0.743309073834957 0.75 5.4 5 4 abnormal skin development 0.147462324382762 0.330164295141423 0.743309073834957 0.75 5.4 5 4 long femur 0.147462324382762 0.330164295141423 0.743309073834957 0.75 5.4 5 4 small frontal bone 0.147462324382762 0.330164295141423 0.743309073834957 0.75 5.4 5 4 abnormal hair follicle melanocyte morphology 0.147462324382762 0.330164295141423 0.743309073834957 0.75 5.4 5 4 abnormal choroid pigmentation 0.147462324382762 0.330164295141423 0.743309073834957 0.75 5.4 5 4 non-pigmented tail tip 0.147462324382762 0.330164295141423 0.743309073834957 0.75 5.4 5 4 ectrodactyly 0.147462324382762 0.330164295141423 0.743309073834957 0.75 5.4 5 4 ocular hypertension 0.147462324382762 0.330164295141423 0.743309073834957 0.75 5.4 5 4 craniofacial phenotype 0.147462324382762 0.330164295141423 0.743309073834957 0.75 5.4 5 4 stomach epithelial hyperplasia 0.147462324382762 0.330164295141423 0.743309073834957 0.75 5.4 5 4 hypergranulosis 0.147462324382762 0.330164295141423 0.743309073834957 0.75 5.4 5 4 enlarged inguinal lymph nodes 0.147462324382762 0.330164295141423 0.743309073834957 0.75 5.4 5 4 abnormal sphingomyelin level 0.147462324382762 0.330164295141423 0.743309073834957 0.75 5.4 5 4 skin fibrosis 0.147462324382762 0.330164295141423 0.743309073834957 0.75 5.4 5 4 abnormal lateral plate mesoderm morphology 0.147462324382762 0.330164295141423 0.743309073834957 0.75 5.4 5 4 abnormal brain ependyma morphology 0.147462324382762 0.330164295141423 0.743309073834957 0.75 5.4 5 4 abnormal circulating serum amyloid protein level 0.147462324382762 0.330164295141423 0.743309073834957 0.75 5.4 5 4 ostium secundum atrial septal defect 0.147462324382762 0.330164295141423 0.743309073834957 0.75 5.4 5 4 anomalous pulmonary venous connection 0.147462324382762 0.330164295141423 0.743309073834957 0.75 5.4 5 4 increased heart right ventricle size 0.147462324382762 0.330164295141423 0.743309073834957 0.75 5.4 5 4 impaired mucociliary clearance 0.147462324382762 0.330164295141423 0.743309073834957 0.75 5.4 5 4 abnormal heart right ventricle pressure 0.147462324382762 0.330164295141423 0.743309073834957 0.75 5.4 5 4 abnormal stomach position or orientation 0.147462324382762 0.330164295141423 0.743309073834957 0.75 5.4 5 4 decreased alveolar lamellar body number 0.147462324382762 0.330164295141423 0.743309073834957 0.75 5.4 5 4 decreased lung compliance 0.147462324382762 0.330164295141423 0.743309073834957 0.75 5.4 5 4 abnormal maxillary prominence morphology 0.147462324382762 0.330164295141423 0.743309073834957 0.75 5.4 5 4 abnormal foramen magnum morphology 0.147462324382762 0.330164295141423 0.743309073834957 0.75 5.4 5 4 absent ureteric bud 0.147462324382762 0.330164295141423 0.743309073834957 0.75 5.4 5 4 abnormal branching involved in ureteric bud morphogenesis 0.147462324382762 0.330164295141423 0.743309073834957 0.75 5.4 5 4 abnormal kidney mesenchyme morphology 0.147462324382762 0.330164295141423 0.743309073834957 0.75 5.4 5 4 increased aorta wall thickness 0.147462324382762 0.330164295141423 0.743309073834957 0.75 5.4 5 4 abnormal macrophage activation involved in immune response 0.147462324382762 0.330164295141423 0.743309073834957 0.75 5.4 5 4 retropleural edema 0.147462324382762 0.330164295141423 0.743309073834957 0.75 5.4 5 4 embryo cyst 0.147462324382762 0.330164295141423 0.743309073834957 0.75 5.4 5 4 increased mammary gland apoptosis 0.147462324382762 0.330164295141423 0.743309073834957 0.75 5.4 5 4 abnormal heart morphology 1.23490457338611e-14 8.30223007107553e-13 0.742236477768817 0.748917748917749 5.4 5 4 respiratory failure 4.98281713066189e-10 1.74574050880584e-08 0.741668214952319 0.748344370860927 5.4 5 4 increased mean corpuscular hemoglobin 5.132441717616e-07 9.7087062909276e-06 0.740806349680631 0.747474747474748 5.4 5 4 abnormal visceral yolk sac morphology 7.57869766387238e-06 0.000113909428633731 0.740172748628902 0.746835443037975 5.4 5 4 abnormal limb morphology 1.30212285998899e-05 0.000181968012034978 0.740005477951246 0.746666666666667 5.4 5 4 small testis 7.24088761779043e-17 7.06341488206027e-15 0.739718208743967 0.746376811594203 5.4 5 4 syndactyly 0.000114990448098149 0.00120946612957355 0.739109587542104 0.745762711864407 5.4 5 4 reduced female fertility 2.44598737750257e-14 1.52109840038441e-12 0.739037182606021 0.745689655172414 5.4 5 4 increased lung adenocarcinoma incidence 0.000345408609535838 0.00310181919213139 0.738450844594206 0.745098039215686 5.4 5 4 abnormal trophoblast layer morphology 0.000345408609535838 0.00310181919213139 0.738450844594206 0.745098039215686 5.4 5 4 abnormal T-helper 1 physiology 0.000600855541247228 0.00503241804327434 0.738037378275844 0.74468085106383 5.4 5 4 thin ventricular wall 2.25467623233509e-06 3.75150978457093e-05 0.737803080695439 0.744444444444444 5.4 5 4 abnormal male reproductive system morphology 0.00104838803698753 0.00791461378454169 0.737546987991275 0.744186046511628 5.4 5 4 abnormal homeostasis 0.00104838803698753 0.00791461378454169 0.737546987991275 0.744186046511628 5.4 5 4 abnormal cornea morphology 1.13708635240592e-05 0.000163497242867614 0.736956004827821 0.743589743589744 5.4 5 4 abnormal heart looping 0.00183585557532504 0.0124943659196198 0.736956004827821 0.743589743589744 5.4 5 4 impaired macrophage chemotaxis 0.00183585557532504 0.0124943659196198 0.736956004827821 0.743589743589744 5.4 5 4 failure of heart looping 0.00183585557532504 0.0124943659196198 0.736956004827821 0.743589743589744 5.4 5 4 abnormal angiogenesis 1.95386498909003e-05 0.000254462783264997 0.7366125956923 0.743243243243243 5.4 5 4 abnormal intestine morphology 1.95386498909003e-05 0.000254462783264997 0.7366125956923 0.743243243243243 5.4 5 4 abnormal liver morphology 3.56774573016199e-11 1.58477991138892e-09 0.736388132737797 0.743016759776536 5.4 5 4 increased circulating serum albumin level 0.00322882584735624 0.0201801615459765 0.736229939798434 0.742857142857143 5.4 5 4 no abnormal phenotype detected 1.28979996082066e-97 3.20837740254139e-94 0.735740316695043 0.742363112391931 5.4 5 4 abnormal eyelid morphology 0.00570920662091025 0.0315241986004756 0.73531650314856 0.741935483870968 5.4 5 4 abnormal nose morphology 0.00570920662091025 0.0315241986004756 0.73531650314856 0.741935483870968 5.4 5 4 decreased neuronal precursor cell number 0.00570920662091025 0.0315241986004756 0.73531650314856 0.741935483870968 5.4 5 4 abnormal spermiogenesis 0.000172644678296466 0.00170418110024786 0.734765291377084 0.741379310344828 5.4 5 4 decreased platelet aggregation 0.000298946946033301 0.00270903653281543 0.734132418602427 0.740740740740741 5.4 5 4 abnormal trigeminal nerve morphology 0.0101632846678255 0.049668311613391 0.734132418602427 0.740740740740741 5.4 5 4 increased brain weight 0.0101632846678255 0.049668311613391 0.734132418602427 0.740740740740741 5.4 5 4 decreased bone ossification 0.0101632846678255 0.049668311613391 0.734132418602427 0.740740740740741 5.4 5 4 increased monocyte cell number 1.00319910358303e-06 1.82150202201663e-05 0.733398286183824 0.74 5.4 5 4 decreased oocyte number 0.000518814103912199 0.00435261410955007 0.733398286183824 0.74 5.4 5 4 thymus hypoplasia 1.0693688838075e-08 3.00571197567361e-07 0.732536478561987 0.739130434782609 5.4 5 4 decreased spleen weight 5.0216586573095e-05 0.000597673488519492 0.732536478561987 0.739130434782609 5.4 5 4 fragile skeleton 0.0182510181478274 0.0771652298087866 0.732536478561987 0.739130434782609 5.4 5 4 abnormal pulmonary artery morphology 0.0182510181478274 0.0771652298087866 0.732536478561987 0.739130434782609 5.4 5 4 blistering 0.0182510181478274 0.0771652298087866 0.732536478561987 0.739130434782609 5.4 5 4 abnormal nasal cavity morphology 0.0182510181478274 0.0771652298087866 0.732536478561987 0.739130434782609 5.4 5 4 abnormal sacral vertebrae morphology 0.0182510181478274 0.0771652298087866 0.732536478561987 0.739130434782609 5.4 5 4 dilated heart 0.0182510181478274 0.0771652298087866 0.732536478561987 0.739130434782609 5.4 5 4 decreased effector memory CD8-positive, alpha-beta T cell number 0.0182510181478274 0.0771652298087866 0.732536478561987 0.739130434782609 5.4 5 4 abnormal skeleton morphology 1.75734643432322e-07 3.78476126006841e-06 0.732536478561987 0.739130434782609 5.4 5 4 abnormal muscle morphology 0.00157562176660825 0.0110560201535629 0.731510517107418 0.738095238095238 5.4 5 4 abnormal long bone morphology 0.000149204385158008 0.00150147776874844 0.731123679181925 0.737704918032787 5.4 5 4 enlarged heart 2.0259569499359e-13 1.13248717145293e-11 0.730493400148148 0.737068965517241 5.4 5 4 impaired righting response 2.54604608642007e-06 4.19423154964896e-05 0.730268563767677 0.736842105263158 5.4 5 4 abnormal facial morphology 0.000257815104680303 0.00244310503958954 0.730268563767677 0.736842105263158 5.4 5 4 abnormal triglyceride level 0.0331628825601179 0.121134611407185 0.730268563767677 0.736842105263158 5.4 5 4 thin dermal layer 0.0331628825601179 0.121134611407185 0.730268563767677 0.736842105263158 5.4 5 4 stereotypic behavior 0.0331628825601179 0.121134611407185 0.730268563767677 0.736842105263158 5.4 5 4 abnormal metatarsal bone morphology 0.0331628825601179 0.121134611407185 0.730268563767677 0.736842105263158 5.4 5 4 abnormal digestive system development 0.0331628825601179 0.121134611407185 0.730268563767677 0.736842105263158 5.4 5 4 decreased liver regeneration 0.0331628825601179 0.121134611407185 0.730268563767677 0.736842105263158 5.4 5 4 shortened RR interval 0.0331628825601179 0.121134611407185 0.730268563767677 0.736842105263158 5.4 5 4 thin interventricular septum 0.0331628825601179 0.121134611407185 0.730268563767677 0.736842105263158 5.4 5 4 right-sided stomach 0.0331628825601179 0.121134611407185 0.730268563767677 0.736842105263158 5.4 5 4 increased sensitivity to xenobiotic induced morbidity/mortality 4.44195198757327e-07 8.49950428391423e-06 0.729794363401594 0.736363636363636 5.4 5 4 azoospermia 1.43873626165379e-09 4.67824372661934e-08 0.729284374328637 0.735849056603774 5.4 5 4 abnormal pancreatic islet morphology 0.00044634896695957 0.00394896812282355 0.729284374328637 0.735849056603774 5.4 5 4 abnormal spleen red pulp morphology 0.004856448657985 0.0274554909925856 0.728734386112703 0.735294117647059 5.4 5 4 abnormal brown adipose tissue morphology 0.004856448657985 0.0274554909925856 0.728734386112703 0.735294117647059 5.4 5 4 increased circulating LDL cholesterol level 0.000774473079927579 0.00626504645957676 0.72813950089955 0.73469387755102 5.4 5 4 decreased circulating creatinine level 0.000774473079927579 0.00626504645957676 0.72813950089955 0.73469387755102 5.4 5 4 increased bone mineral density 3.85243916994659e-07 7.51603328254286e-06 0.727960508888513 0.734513274336283 5.4 5 4 decreased caudal vertebrae number 0.000128568301318833 0.00134346219595139 0.727823468130062 0.734375 5.4 5 4 abnormal myocardium layer morphology 2.1844464471242e-05 0.000281544587420801 0.727627447804684 0.734177215189873 5.4 5 4 male infertility 1.28591080530288e-26 3.36705592441148e-24 0.727053805818686 0.733598409542744 5.4 5 4 epidermal hyperplasia 0.000221682801728382 0.00213321458142882 0.726791094416403 0.733333333333333 5.4 5 4 gastrointestinal hemorrhage 0.00859153121166536 0.0431310472028609 0.726791094416403 0.733333333333333 5.4 5 4 abnormal microglial cell physiology 0.00859153121166536 0.0431310472028609 0.726791094416403 0.733333333333333 5.4 5 4 decreased chondrocyte number 0.0612742885348223 0.186639416788461 0.726791094416403 0.733333333333333 5.4 5 4 vagina atresia 0.0612742885348223 0.186639416788461 0.726791094416403 0.733333333333333 5.4 5 4 abnormal cricoid cartilage morphology 0.0612742885348223 0.186639416788461 0.726791094416403 0.733333333333333 5.4 5 4 arthritis 0.0612742885348223 0.186639416788461 0.726791094416403 0.733333333333333 5.4 5 4 dilated ureter 0.0612742885348223 0.186639416788461 0.726791094416403 0.733333333333333 5.4 5 4 abnormal glial cell morphology 0.0612742885348223 0.186639416788461 0.726791094416403 0.733333333333333 5.4 5 4 ostium primum atrial septal defect 0.0612742885348223 0.186639416788461 0.726791094416403 0.733333333333333 5.4 5 4 bicuspid aortic valve 0.0612742885348223 0.186639416788461 0.726791094416403 0.733333333333333 5.4 5 4 increased circulating corticosterone level 0.00134728298200955 0.00984248580836637 0.726791094416402 0.733333333333333 5.4 5 4 decreased B cell number 1.04239543690455e-11 4.93896885580966e-10 0.726470356951965 0.733009708737864 5.4 5 4 increased circulating cholesterol level 3.27553949966253e-10 1.20709696376452e-08 0.726415685793254 0.732954545454545 5.4 5 4 increased circulating free fatty acid level 6.43066494547297e-05 0.000733774268434128 0.725860504026625 0.732394366197183 5.4 5 4 increased circulating triglyceride level 1.52494629135566e-08 4.07882139757764e-07 0.724512752427636 0.731034482758621 5.4 5 4 abnormal skin condition 0.000662457180256967 0.00548373456202731 0.724249866813548 0.730769230769231 5.4 5 4 abnormal lipid homeostasis 8.62759836124533e-08 1.98714360403683e-06 0.724249866813548 0.730769230769231 5.4 5 4 increased rib number 3.22465185301453e-05 0.000402071252349556 0.724249866813548 0.730769230769231 5.4 5 4 increased circulating alanine transaminase level 3.22465185301453e-05 0.000402071252349556 0.724249866813548 0.730769230769231 5.4 5 4 abnormal hair follicle morphology 0.000190138236688688 0.00185842382618118 0.723644812622392 0.73015873015873 5.4 5 4 small seminiferous tubules 5.52599437219731e-05 0.000653012399089825 0.723219639406985 0.72972972972973 5.4 5 4 increased trabecular bone volume 0.00411672689458032 0.0235681430385928 0.723219639406985 0.72972972972973 5.4 5 4 abnormal cardiovascular system morphology 0.00114868809990696 0.00859356886772498 0.722661599561764 0.729166666666667 5.4 5 4 increased T cell proliferation 1.41983526135125e-06 2.48721141733186e-05 0.722468632512482 0.728971962616822 5.4 5 4 insulin resistance 1.09013677680636e-07 2.44298669577102e-06 0.720784556446019 0.727272727272727 5.4 5 4 abnormal tooth development 0.00724030455918952 0.0376389918306874 0.720784556446019 0.727272727272727 5.4 5 4 abnormal aorta morphology 0.00724030455918952 0.0376389918306874 0.720784556446019 0.727272727272727 5.4 5 4 decreased brown adipose tissue amount 0.00724030455918952 0.0376389918306874 0.720784556446019 0.727272727272727 5.4 5 4 decreased systemic arterial blood pressure 0.00724030455918952 0.0376389918306874 0.720784556446019 0.727272727272727 5.4 5 4 increased cardiomyocyte apoptosis 0.00724030455918952 0.0376389918306874 0.720784556446019 0.727272727272727 5.4 5 4 hyperglycemia 1.39209993886739e-05 0.000192395962613039 0.720784556446019 0.727272727272727 5.4 5 4 omphalocele 0.00199672327331802 0.0134376215235974 0.720784556446019 0.727272727272727 5.4 5 4 lethality, incomplete penetrance 0.00199672327331802 0.0134376215235974 0.720784556446019 0.727272727272727 5.4 5 4 embryonic lethality, incomplete penetrance 0.00199672327331802 0.0134376215235974 0.720784556446019 0.727272727272727 5.4 5 4 abnormal basisphenoid bone morphology 0.0275017759701048 0.107265351620516 0.720784556446019 0.727272727272727 5.4 5 4 abnormal germ layer development 0.0275017759701048 0.107265351620516 0.720784556446019 0.727272727272727 5.4 5 4 abnormal chorion morphology 0.0275017759701048 0.107265351620516 0.720784556446019 0.727272727272727 5.4 5 4 aphakia 0.0275017759701048 0.107265351620516 0.720784556446019 0.727272727272727 5.4 5 4 abnormal cochlear sensory epithelium morphology 0.0275017759701048 0.107265351620516 0.720784556446019 0.727272727272727 5.4 5 4 abnormal retinal outer plexiform layer morphology 0.0275017759701048 0.107265351620516 0.720784556446019 0.727272727272727 5.4 5 4 prolonged PR interval 0.0275017759701048 0.107265351620516 0.720784556446019 0.727272727272727 5.4 5 4 cleft upper lip 0.0275017759701048 0.107265351620516 0.720784556446019 0.727272727272727 5.4 5 4 abnormal temporal bone morphology 0.0275017759701048 0.107265351620516 0.720784556446019 0.727272727272727 5.4 5 4 increased mammary gland tumor incidence 0.0275017759701048 0.107265351620516 0.720784556446019 0.727272727272727 5.4 5 4 increased bone volume 0.0275017759701048 0.107265351620516 0.720784556446019 0.727272727272727 5.4 5 4 abnormal ear position 0.116156822396404 0.294493642506925 0.720784556446019 0.727272727272727 5.4 5 4 decreased atrioventricular cushion size 0.116156822396404 0.294493642506925 0.720784556446019 0.727272727272727 5.4 5 4 abnormal awl hair morphology 0.116156822396404 0.294493642506925 0.720784556446019 0.727272727272727 5.4 5 4 abnormal hemoglobin 0.116156822396404 0.294493642506925 0.720784556446019 0.727272727272727 5.4 5 4 impaired myelopoiesis 0.116156822396404 0.294493642506925 0.720784556446019 0.727272727272727 5.4 5 4 abnormal bronchiole morphology 0.116156822396404 0.294493642506925 0.720784556446019 0.727272727272727 5.4 5 4 abnormal vestibular ganglion morphology 0.116156822396404 0.294493642506925 0.720784556446019 0.727272727272727 5.4 5 4 allodynia 0.116156822396404 0.294493642506925 0.720784556446019 0.727272727272727 5.4 5 4 abnormal frequency of paradoxical sleep 0.116156822396404 0.294493642506925 0.720784556446019 0.727272727272727 5.4 5 4 impaired luteinization 0.116156822396404 0.294493642506925 0.720784556446019 0.727272727272727 5.4 5 4 abnormal ureter development 0.116156822396404 0.294493642506925 0.720784556446019 0.727272727272727 5.4 5 4 abnormal crista ampullaris neuroepithelium morphology 0.116156822396404 0.294493642506925 0.720784556446019 0.727272727272727 5.4 5 4 increased motor neuron number 0.116156822396404 0.294493642506925 0.720784556446019 0.727272727272727 5.4 5 4 increased circulating triiodothyronine level 0.116156822396404 0.294493642506925 0.720784556446019 0.727272727272727 5.4 5 4 enhanced behavioral response to addictive substance 0.116156822396404 0.294493642506925 0.720784556446019 0.727272727272727 5.4 5 4 decreased core body temperature 0.116156822396404 0.294493642506925 0.720784556446019 0.727272727272727 5.4 5 4 abnormal phrenic nerve innervation pattern to diaphragm 0.116156822396404 0.294493642506925 0.720784556446019 0.727272727272727 5.4 5 4 decreased colon length 0.116156822396404 0.294493642506925 0.720784556446019 0.727272727272727 5.4 5 4 abnormal enzyme/coenzyme activity 8.46496025482824e-09 2.43428770333934e-07 0.719636810337029 0.726114649681529 5.4 5 4 enlarged spleen 7.17342786106494e-15 5.02645121250677e-13 0.719220353849565 0.725694444444444 5.4 5 4 small spleen 1.19407066620478e-05 0.000170214944537787 0.718804379093145 0.725274725274725 5.4 5 4 abnormal female reproductive system morphology 0.00348083606548886 0.0214056358786243 0.718532104707125 0.725 5.4 5 4 abnormal pancreatic beta cell morphology 0.00348083606548886 0.0214056358786243 0.718532104707125 0.725 5.4 5 4 abnormal sternum morphology 0.000139032177515693 0.00143595479358439 0.718173018198026 0.72463768115942 5.4 5 4 thrombocytopenia 4.1004581182429e-08 9.99989173444041e-07 0.717677726461338 0.724137931034483 5.4 5 4 abnormal middle ear morphology 0.0128015510211484 0.0590247602689652 0.717677726461338 0.724137931034483 5.4 5 4 decreased bone strength 0.0128015510211484 0.0590247602689652 0.717677726461338 0.724137931034483 5.4 5 4 increased retinal apoptosis 0.0128015510211484 0.0590247602689652 0.717677726461338 0.724137931034483 5.4 5 4 decreased circulating glucose level 2.96769473815982e-14 1.82275078053643e-12 0.717555234956565 0.724014336917563 5.4 5 4 abnormal lipid level 3.47026612158815e-05 0.000427340939477749 0.716442480804778 0.72289156626506 5.4 5 4 abnormal spermatogenesis 8.27709852128704e-10 2.78233548266237e-08 0.716377585652531 0.722826086956522 5.4 5 4 abnormal long bone epiphyseal plate proliferative zone 0.000829594221367878 0.00650982847209021 0.715779108137366 0.722222222222222 5.4 5 4 short radius 0.00608868049253001 0.0329748626032959 0.715779108137366 0.722222222222222 5.4 5 4 abnormal megakaryocyte differentiation 0.0500153358408061 0.166773656707782 0.715779108137366 0.722222222222222 5.4 5 4 right pulmonary isomerism 0.0500153358408061 0.166773656707782 0.715779108137366 0.722222222222222 5.4 5 4 abnormal radius morphology 0.0500153358408061 0.166773656707782 0.715779108137366 0.722222222222222 5.4 5 4 blepharoptosis 0.0500153358408061 0.166773656707782 0.715779108137366 0.722222222222222 5.4 5 4 cachexia 4.40723577049582e-06 6.93860694880275e-05 0.714720263302843 0.721153846153846 5.4 5 4 decreased mean corpuscular hemoglobin 0.000202929130976153 0.00197567989551147 0.714159698390449 0.720588235294118 5.4 5 4 weight loss 3.4086830534845e-09 1.04680235747441e-07 0.713576710881559 0.72 5.4 5 4 increased circulating chloride level 0.0014318818753957 0.0101475959118143 0.713576710881559 0.72 5.4 5 4 abnormal circulating protein level 0.0014318818753957 0.0101475959118143 0.713576710881559 0.72 5.4 5 4 abnormal keratinocyte physiology 0.0227849028575902 0.0909750334803461 0.713576710881559 0.72 5.4 5 4 abnormal energy expenditure 0.0227849028575902 0.0909750334803461 0.713576710881559 0.72 5.4 5 4 abnormal preimplantation embryo development 0.0227849028575902 0.0909750334803461 0.713576710881559 0.72 5.4 5 4 increased liver glycogen level 0.0227849028575902 0.0909750334803461 0.713576710881559 0.72 5.4 5 4 anophthalmia 2.52778822190002e-05 0.000322455035998785 0.712685853564603 0.719101123595506 5.4 5 4 decreased lymphocyte cell number 4.85851235370689e-07 9.2609574558206e-06 0.712337862425167 0.71875 5.4 5 4 abnormal serotonin level 0.0106935681650015 0.0522085393727991 0.712337862425167 0.71875 5.4 5 4 decreased compact bone thickness 0.000294679873247997 0.00268996765029135 0.710026577991601 0.716417910447761 5.4 5 4 teratozoospermia 3.6558494967285e-05 0.000444690739516486 0.70952229775155 0.715909090909091 5.4 5 4 abnormal seminal vesicle morphology 0.00102130523647938 0.00777367409278748 0.70791340365234 0.714285714285714 5.4 5 4 reddish skin 0.0188735620972321 0.0792371066951304 0.70791340365234 0.714285714285714 5.4 5 4 corneal vascularization 0.0188735620972321 0.0792371066951304 0.70791340365234 0.714285714285714 5.4 5 4 abnormal interparietal bone morphology 0.0925054586400677 0.251896363839265 0.70791340365234 0.714285714285714 5.4 5 4 midline facial cleft 0.0925054586400677 0.251896363839265 0.70791340365234 0.714285714285714 5.4 5 4 absent atrioventricular cushions 0.0925054586400677 0.251896363839265 0.70791340365234 0.714285714285714 5.4 5 4 abnormal zigzag hair morphology 0.0925054586400677 0.251896363839265 0.70791340365234 0.714285714285714 5.4 5 4 irregularly shaped pupil 0.0925054586400677 0.251896363839265 0.70791340365234 0.714285714285714 5.4 5 4 abnormal pinna reflex 0.0925054586400677 0.251896363839265 0.70791340365234 0.714285714285714 5.4 5 4 extended life span 0.0925054586400677 0.251896363839265 0.70791340365234 0.714285714285714 5.4 5 4 abnormal endplate potential 0.0925054586400677 0.251896363839265 0.70791340365234 0.714285714285714 5.4 5 4 increased lactate dehydrogenase level 0.0925054586400677 0.251896363839265 0.70791340365234 0.714285714285714 5.4 5 4 decreased coping response 0.0925054586400677 0.251896363839265 0.70791340365234 0.714285714285714 5.4 5 4 intestinal obstruction 0.0925054586400677 0.251896363839265 0.70791340365234 0.714285714285714 5.4 5 4 abnormal ventral body wall morphology 0.0925054586400677 0.251896363839265 0.70791340365234 0.714285714285714 5.4 5 4 absent olfactory bulb 0.0925054586400677 0.251896363839265 0.70791340365234 0.714285714285714 5.4 5 4 abnormal vascular endothelial cell migration 0.0925054586400677 0.251896363839265 0.70791340365234 0.714285714285714 5.4 5 4 abnormal imprinting 0.0925054586400677 0.251896363839265 0.70791340365234 0.714285714285714 5.4 5 4 split sternum 0.0925054586400677 0.251896363839265 0.70791340365234 0.714285714285714 5.4 5 4 abnormal iris pigmentation 0.0925054586400677 0.251896363839265 0.70791340365234 0.714285714285714 5.4 5 4 increased circulating growth hormone level 0.0925054586400677 0.251896363839265 0.70791340365234 0.714285714285714 5.4 5 4 increased lung compliance 0.0925054586400677 0.251896363839265 0.70791340365234 0.714285714285714 5.4 5 4 pulmonary alveolar hemorrhage 0.0925054586400677 0.251896363839265 0.70791340365234 0.714285714285714 5.4 5 4 decreased response to antigen 0.0925054586400677 0.251896363839265 0.70791340365234 0.714285714285714 5.4 5 4 asymmetric rib joints 0.230230366737549 0.451559484641431 0.70791340365234 0.714285714285714 5.4 5 4 maxilla hypoplasia 0.230230366737549 0.451559484641431 0.70791340365234 0.714285714285714 5.4 5 4 prostate gland epithelial hyperplasia 0.230230366737549 0.451559484641431 0.70791340365234 0.714285714285714 5.4 5 4 absent epidermis stratum corneum 0.230230366737549 0.451559484641431 0.70791340365234 0.714285714285714 5.4 5 4 abnormal lacrimal gland morphology 0.230230366737549 0.451559484641431 0.70791340365234 0.714285714285714 5.4 5 4 abnormal vascular permeability 0.230230366737549 0.451559484641431 0.70791340365234 0.714285714285714 5.4 5 4 abnormal axial mesoderm 0.230230366737549 0.451559484641431 0.70791340365234 0.714285714285714 5.4 5 4 absent amniotic folds 0.230230366737549 0.451559484641431 0.70791340365234 0.714285714285714 5.4 5 4 increased chemically-elicited antinociception 0.230230366737549 0.451559484641431 0.70791340365234 0.714285714285714 5.4 5 4 increased colonic adenoma incidence 0.230230366737549 0.451559484641431 0.70791340365234 0.714285714285714 5.4 5 4 abnormal hypersensitivity reaction 0.230230366737549 0.451559484641431 0.70791340365234 0.714285714285714 5.4 5 4 abnormal lymph node primary follicle morphology 0.230230366737549 0.451559484641431 0.70791340365234 0.714285714285714 5.4 5 4 abnormal inhibitory postsynaptic potential 0.230230366737549 0.451559484641431 0.70791340365234 0.714285714285714 5.4 5 4 decreased urine calcium level 0.230230366737549 0.451559484641431 0.70791340365234 0.714285714285714 5.4 5 4 absent tunnel of Corti 0.230230366737549 0.451559484641431 0.70791340365234 0.714285714285714 5.4 5 4 calcinosis 0.230230366737549 0.451559484641431 0.70791340365234 0.714285714285714 5.4 5 4 abnormal sinus venosus morphology 0.230230366737549 0.451559484641431 0.70791340365234 0.714285714285714 5.4 5 4 increased muscle weight 0.230230366737549 0.451559484641431 0.70791340365234 0.714285714285714 5.4 5 4 abnormal prostate gland physiology 0.230230366737549 0.451559484641431 0.70791340365234 0.714285714285714 5.4 5 4 anuria 0.230230366737549 0.451559484641431 0.70791340365234 0.714285714285714 5.4 5 4 abnormal locus ceruleus morphology 0.230230366737549 0.451559484641431 0.70791340365234 0.714285714285714 5.4 5 4 abnormal organ of Corti supporting cell morphology 0.230230366737549 0.451559484641431 0.70791340365234 0.714285714285714 5.4 5 4 abnormal vestibular saccular macula morphology 0.230230366737549 0.451559484641431 0.70791340365234 0.714285714285714 5.4 5 4 absent ulna 0.230230366737549 0.451559484641431 0.70791340365234 0.714285714285714 5.4 5 4 abnormal negative T cell selection 0.230230366737549 0.451559484641431 0.70791340365234 0.714285714285714 5.4 5 4 decreased adrenocorticotropin level 0.230230366737549 0.451559484641431 0.70791340365234 0.714285714285714 5.4 5 4 absent thyroid gland 0.230230366737549 0.451559484641431 0.70791340365234 0.714285714285714 5.4 5 4 increased chronic myelocytic leukemia incidence 0.230230366737549 0.451559484641431 0.70791340365234 0.714285714285714 5.4 5 4 abnormal body temperature 0.230230366737549 0.451559484641431 0.70791340365234 0.714285714285714 5.4 5 4 retinal pigment epithelium atrophy 0.230230366737549 0.451559484641431 0.70791340365234 0.714285714285714 5.4 5 4 absent popliteal lymph nodes 0.230230366737549 0.451559484641431 0.70791340365234 0.714285714285714 5.4 5 4 abnormal sperm annulus morphology 0.230230366737549 0.451559484641431 0.70791340365234 0.714285714285714 5.4 5 4 abnormal cerebellum white matter morphology 0.230230366737549 0.451559484641431 0.70791340365234 0.714285714285714 5.4 5 4 arteritis 0.230230366737549 0.451559484641431 0.70791340365234 0.714285714285714 5.4 5 4 focal dorsal hair loss 0.230230366737549 0.451559484641431 0.70791340365234 0.714285714285714 5.4 5 4 decreased T-helper 17 cell number 0.230230366737549 0.451559484641431 0.70791340365234 0.714285714285714 5.4 5 4 decreased skeletal muscle glycogen level 0.230230366737549 0.451559484641431 0.70791340365234 0.714285714285714 5.4 5 4 heart right ventricle outflow tract stenosis 0.230230366737549 0.451559484641431 0.70791340365234 0.714285714285714 5.4 5 4 thick mitral valve cusps 0.230230366737549 0.451559484641431 0.70791340365234 0.714285714285714 5.4 5 4 abnormal impulsive behavior control 0.230230366737549 0.451559484641431 0.70791340365234 0.714285714285714 5.4 5 4 increased right ventricle systolic pressure 0.230230366737549 0.451559484641431 0.70791340365234 0.714285714285714 5.4 5 4 abnormal tricarboxylic acid cycle 0.230230366737549 0.451559484641431 0.70791340365234 0.714285714285714 5.4 5 4 small lung lobe 0.230230366737549 0.451559484641431 0.70791340365234 0.714285714285714 5.4 5 4 small tail bud 0.230230366737549 0.451559484641431 0.70791340365234 0.714285714285714 5.4 5 4 absent heart tube 0.230230366737549 0.451559484641431 0.70791340365234 0.714285714285714 5.4 5 4 decreased CD8-positive, naive alpha-beta T cell number 0.230230366737549 0.451559484641431 0.70791340365234 0.714285714285714 5.4 5 4 decreased volumetric bone mineral density 0.230230366737549 0.451559484641431 0.70791340365234 0.714285714285714 5.4 5 4 decreased femur compact bone thickness 0.230230366737549 0.451559484641431 0.70791340365234 0.714285714285714 5.4 5 4 abnormal Mullerian duct topology 0.230230366737549 0.451559484641431 0.70791340365234 0.714285714285714 5.4 5 4 absent connection between subcutaneous lymph vessels and lymph sac 0.230230366737549 0.451559484641431 0.70791340365234 0.714285714285714 5.4 5 4 decreased collagen level 0.230230366737549 0.451559484641431 0.70791340365234 0.714285714285714 5.4 5 4 disheveled coat 0.0042889318267627 0.0244415072601884 0.70791340365234 0.714285714285714 5.4 5 4 skin edema 0.0042889318267627 0.0244415072601884 0.70791340365234 0.714285714285714 5.4 5 4 abnormal hematopoietic system physiology 0.0409005120839552 0.139084106368884 0.70791340365234 0.714285714285714 5.4 5 4 decreased glycogen level 0.00892550568455688 0.0444043907806705 0.70791340365234 0.714285714285714 5.4 5 4 abnormal spleen morphology 1.24649334725183e-08 3.44516911254326e-07 0.706286016517507 0.71264367816092 5.4 5 4 microphthalmia 9.51682769697566e-08 2.16192775308009e-06 0.706062649655863 0.712418300653595 5.4 5 4 decreased bone marrow cell number 0.000211332734513798 0.00205347725430888 0.70597391487521 0.712328767123288 5.4 5 4 absent corpus luteum 0.00175321914026231 0.012216057735021 0.705190659792139 0.711538461538462 5.4 5 4 small placenta 0.00359534552884655 0.0219470478601369 0.70476712185833 0.711111111111111 5.4 5 4 cardiomyopathy 0.00359534552884655 0.0219470478601369 0.70476712185833 0.711111111111111 5.4 5 4 hyporesponsive to tactile stimuli 0.00744660228393008 0.0386307052789908 0.704187543633117 0.710526315789474 5.4 5 4 increased leukocyte cell number 2.68232976007358e-07 5.40266824144374e-06 0.704007674528741 0.710344827586207 5.4 5 4 absent mature ovarian follicles 0.0156372135446223 0.0695152957111566 0.70334622040297 0.709677419354839 5.4 5 4 increased lung adenoma incidence 0.0156372135446223 0.0695152957111566 0.70334622040297 0.709677419354839 5.4 5 4 abnormal podocyte morphology 0.0156372135446223 0.0695152957111566 0.70334622040297 0.709677419354839 5.4 5 4 small cranium 0.0156372135446223 0.0695152957111566 0.70334622040297 0.709677419354839 5.4 5 4 increased circulating calcium level 0.00147387650861436 0.0104155335658472 0.702764942534869 0.709090909090909 5.4 5 4 decreased circulating calcium level 0.00147387650861436 0.0104155335658472 0.702764942534869 0.709090909090909 5.4 5 4 abnormal glucose homeostasis 1.09928805080753e-08 3.07244834425138e-07 0.702467915931937 0.708791208791209 5.4 5 4 oligodactyly 0.00301250073470192 0.0189711280444836 0.702014125288571 0.708333333333333 5.4 5 4 abnormal adrenal gland morphology 0.0335127980024822 0.121290441183098 0.702014125288571 0.708333333333333 5.4 5 4 hemolytic anemia 0.0335127980024822 0.121290441183098 0.702014125288571 0.708333333333333 5.4 5 4 abnormal osteoblast morphology 0.0335127980024822 0.121290441183098 0.702014125288571 0.708333333333333 5.4 5 4 short ulna 0.00621162796053415 0.0335171899171989 0.701006931421586 0.707317073170732 5.4 5 4 abnormal cholesterol homeostasis 0.00621162796053415 0.0335171899171989 0.701006931421586 0.707317073170732 5.4 5 4 abnormal gluconeogenesis 0.00252335824834036 0.0159919838031762 0.699585010668195 0.705882352941177 5.4 5 4 overexpanded pulmonary alveoli 0.0129615587220805 0.0596519469401947 0.699585010668195 0.705882352941177 5.4 5 4 abnormal vision 0.0129615587220805 0.0596519469401947 0.699585010668195 0.705882352941177 5.4 5 4 abnormal urinary bladder morphology 0.0742533987124768 0.214014009053733 0.699585010668195 0.705882352941177 5.4 5 4 aminoaciduria 0.0742533987124768 0.214014009053733 0.699585010668195 0.705882352941177 5.4 5 4 pancytopenia 0.0742533987124768 0.214014009053733 0.699585010668195 0.705882352941177 5.4 5 4 increased circulating magnesium level 0.0742533987124768 0.214014009053733 0.699585010668195 0.705882352941177 5.4 5 4 abnormal circulating chemokine level 0.0742533987124768 0.214014009053733 0.699585010668195 0.705882352941177 5.4 5 4 increased hepatoma incidence 0.0742533987124768 0.214014009053733 0.699585010668195 0.705882352941177 5.4 5 4 common atrium 0.0742533987124768 0.214014009053733 0.699585010668195 0.705882352941177 5.4 5 4 abnormal ductus venosus valve morphology 0.0742533987124768 0.214014009053733 0.699585010668195 0.705882352941177 5.4 5 4 alopecia 4.56712743808804e-05 0.000547505036252723 0.698971339606205 0.705263157894737 5.4 5 4 increased osteoclast cell number 0.00104028648106258 0.0078773595788224 0.698629293440506 0.704918032786885 5.4 5 4 abnormal myelopoiesis 0.00518137206600964 0.0288659865939507 0.698260039057081 0.704545454545455 5.4 5 4 renal interstitial fibrosis 0.00518137206600964 0.0288659865939507 0.698260039057081 0.704545454545455 5.4 5 4 abnormal amino acid level 0.00518137206600964 0.0288659865939507 0.698260039057081 0.704545454545455 5.4 5 4 rectal prolapse 0.0275116761141263 0.107265351620516 0.697425797672306 0.703703703703704 5.4 5 4 abnormal bone trabecula morphology 0.0275116761141263 0.107265351620516 0.697425797672306 0.703703703703704 5.4 5 4 abnormal B cell differentiation 7.68299573531339e-05 0.000858941658049082 0.697022428211535 0.703296703296703 5.4 5 4 abnormal tooth morphology 0.000873590447799846 0.00684427161858934 0.696852256720272 0.703125 5.4 5 4 abnormal humerus morphology 0.0107496617240475 0.0524309481148393 0.696433726836356 0.702702702702703 5.4 5 4 hydronephrosis 0.00015330948521334 0.00153155560027383 0.696114846924801 0.702380952380952 5.4 5 4 abnormal blood homeostasis 1.17319894082359e-05 0.00016820359454171 0.695493870254931 0.701754385964912 5.4 5 4 abnormal circulating amino acid level 0.00176957795457745 0.0122552246017582 0.695493870254931 0.701754385964912 5.4 5 4 increased circulating insulin level 2.84248089107733e-07 5.70215420689907e-06 0.693755135579293 0.7 5.4 5 4 abnormal long bone epiphyseal plate morphology 0.00148174859807542 0.0104415003901207 0.693755135579293 0.7 5.4 5 4 abnormal eye physiology 0.00148174859807542 0.0104415003901207 0.693755135579293 0.7 5.4 5 4 abnormal fat pad morphology 0.0226249305766088 0.0906272380182196 0.693755135579293 0.7 5.4 5 4 abnormal optic stalk morphology 0.0599600478010883 0.186639416788461 0.693755135579293 0.7 5.4 5 4 dilated vasculature 0.0599600478010883 0.186639416788461 0.693755135579293 0.7 5.4 5 4 abnormal incus morphology 0.0599600478010883 0.186639416788461 0.693755135579293 0.7 5.4 5 4 decreased circulating VLDL cholesterol level 0.0599600478010883 0.186639416788461 0.693755135579293 0.7 5.4 5 4 abnormal auchene hair morphology 0.175538927060002 0.382525695192077 0.693755135579293 0.7 5.4 5 4 absent palatine bone horizontal plate 0.175538927060002 0.382525695192077 0.693755135579293 0.7 5.4 5 4 enlarged testis 0.175538927060002 0.382525695192077 0.693755135579293 0.7 5.4 5 4 abnormal prostate gland epithelium morphology 0.175538927060002 0.382525695192077 0.693755135579293 0.7 5.4 5 4 abnormal grooming behavior 0.175538927060002 0.382525695192077 0.693755135579293 0.7 5.4 5 4 abnormal immune cell physiology 0.175538927060002 0.382525695192077 0.693755135579293 0.7 5.4 5 4 abnormal mammary gland physiology 0.175538927060002 0.382525695192077 0.693755135579293 0.7 5.4 5 4 alcohol preference 0.175538927060002 0.382525695192077 0.693755135579293 0.7 5.4 5 4 abnormal respiratory mechanics 0.175538927060002 0.382525695192077 0.693755135579293 0.7 5.4 5 4 ketoaciduria 0.175538927060002 0.382525695192077 0.693755135579293 0.7 5.4 5 4 primary sex reversal 0.175538927060002 0.382525695192077 0.693755135579293 0.7 5.4 5 4 rickets 0.175538927060002 0.382525695192077 0.693755135579293 0.7 5.4 5 4 cochlear ganglion hypoplasia 0.175538927060002 0.382525695192077 0.693755135579293 0.7 5.4 5 4 abnormal glial cell physiology 0.175538927060002 0.382525695192077 0.693755135579293 0.7 5.4 5 4 abnormal submandibular gland morphology 0.175538927060002 0.382525695192077 0.693755135579293 0.7 5.4 5 4 increased left ventricle diastolic pressure 0.175538927060002 0.382525695192077 0.693755135579293 0.7 5.4 5 4 absent pharyngeal arches 0.175538927060002 0.382525695192077 0.693755135579293 0.7 5.4 5 4 abnormal utricular macula morphology 0.175538927060002 0.382525695192077 0.693755135579293 0.7 5.4 5 4 abnormal deltoid tuberosity morphology 0.175538927060002 0.382525695192077 0.693755135579293 0.7 5.4 5 4 ascites 0.175538927060002 0.382525695192077 0.693755135579293 0.7 5.4 5 4 abnormal gonadal fat pad morphology 0.175538927060002 0.382525695192077 0.693755135579293 0.7 5.4 5 4 increased platelet aggregation 0.175538927060002 0.382525695192077 0.693755135579293 0.7 5.4 5 4 absent inguinal lymph nodes 0.175538927060002 0.382525695192077 0.693755135579293 0.7 5.4 5 4 protruding tongue 0.175538927060002 0.382525695192077 0.693755135579293 0.7 5.4 5 4 increased serotonin level 0.175538927060002 0.382525695192077 0.693755135579293 0.7 5.4 5 4 increased circulating fructosamine level 0.175538927060002 0.382525695192077 0.693755135579293 0.7 5.4 5 4 increased T-helper 17 cell number 0.175538927060002 0.382525695192077 0.693755135579293 0.7 5.4 5 4 abnormal vibrissa follicle morphology 0.175538927060002 0.382525695192077 0.693755135579293 0.7 5.4 5 4 increased kidney iron level 0.175538927060002 0.382525695192077 0.693755135579293 0.7 5.4 5 4 aorta stenosis 0.175538927060002 0.382525695192077 0.693755135579293 0.7 5.4 5 4 abnormal inferior vena cava valve morphology 0.175538927060002 0.382525695192077 0.693755135579293 0.7 5.4 5 4 decreased macrophage apoptosis 0.175538927060002 0.382525695192077 0.693755135579293 0.7 5.4 5 4 lethality during fetal growth through weaning, complete penetrance 0.175538927060002 0.382525695192077 0.693755135579293 0.7 5.4 5 4 decreased circulating lactate level 0.175538927060002 0.382525695192077 0.693755135579293 0.7 5.4 5 4 dehydration 0.00061572751431407 0.00514830988859243 0.693755135579293 0.7 5.4 5 4 increased spleen weight 1.65516893647678e-05 0.000220172873234544 0.692878074725211 0.699115044247788 5.4 5 4 improved glucose tolerance 1.63651272510093e-08 4.307751749935e-07 0.692743830716933 0.698979591836735 5.4 5 4 decreased susceptibility to hepatic steatosis 0.00124074481894733 0.00917918985243888 0.692181994682288 0.698412698412698 5.4 5 4 abnormal coat/ hair morphology 0.00300957222320738 0.0189711280444836 0.691885175645117 0.69811320754717 5.4 5 4 decreased oxygen consumption 0.00740729242361097 0.0384668891518419 0.69145030124182 0.697674418604651 5.4 5 4 decreased litter size 2.03720593165585e-11 9.13072027926833e-10 0.691286256093246 0.697508896797153 5.4 5 4 abnormal tail morphology 0.00103898441029754 0.0078773595788224 0.690751866594102 0.696969696969697 5.4 5 4 cardiovascular system phenotype 0.018636074458369 0.0783723334153726 0.690751866594102 0.696969696969697 5.4 5 4 decreased sensitivity to xenobiotic induced morbidity/mortality 0.018636074458369 0.0783723334153726 0.690751866594102 0.696969696969697 5.4 5 4 decreased B cell proliferation 0.000364104463633631 0.0032638192911303 0.689991545332028 0.69620253164557 5.4 5 4 abnormal innervation pattern to muscle 0.0486463652781676 0.162754315574233 0.689446097470105 0.695652173913043 5.4 5 4 bidirectional circling 0.0486463652781676 0.162754315574233 0.689446097470105 0.695652173913043 5.4 5 4 failure of embryo implantation 0.0486463652781676 0.162754315574233 0.689446097470105 0.695652173913043 5.4 5 4 abnormal vertebral artery topology 0.0486463652781676 0.162754315574233 0.689446097470105 0.695652173913043 5.4 5 4 female infertility 1.08421906390006e-10 4.48117986814187e-09 0.689284103556226 0.695488721804511 5.4 5 4 increased circulating glucose level 2.55524134731267e-06 4.19548703065365e-05 0.688834886390788 0.695035460992908 5.4 5 4 abnormal epidermis stratum granulosum morphology 0.0153728356664361 0.0695152957111566 0.688249142439775 0.694444444444444 5.4 5 4 impaired wound healing 0.0153728356664361 0.0695152957111566 0.688249142439775 0.694444444444444 5.4 5 4 abnormal reflex 0.0153728356664361 0.0695152957111566 0.688249142439775 0.694444444444444 5.4 5 4 head tilt 0.0153728356664361 0.0695152957111566 0.688249142439775 0.694444444444444 5.4 5 4 circling 0.000256491379873753 0.00244097220582166 0.687925260490392 0.694117647058824 5.4 5 4 abnormal snout morphology 0.004256171241516 0.0243105073783491 0.68613145277073 0.692307692307692 5.4 5 4 increased percent body fat/body weight 0.004256171241516 0.0243105073783491 0.68613145277073 0.692307692307692 5.4 5 4 abnormal Schwann cell morphology 0.0396179494870267 0.13582668280632 0.68613145277073 0.692307692307692 5.4 5 4 thick skin 0.0396179494870267 0.13582668280632 0.68613145277073 0.692307692307692 5.4 5 4 short premaxilla 0.136927536031949 0.315231139175819 0.68613145277073 0.692307692307692 5.4 5 4 increased foot pad pigmentation 0.136927536031949 0.315231139175819 0.68613145277073 0.692307692307692 5.4 5 4 abnormal sympathetic ganglion morphology 0.136927536031949 0.315231139175819 0.68613145277073 0.692307692307692 5.4 5 4 uterus hypoplasia 0.136927536031949 0.315231139175819 0.68613145277073 0.692307692307692 5.4 5 4 increased pituitary adenoma incidence 0.136927536031949 0.315231139175819 0.68613145277073 0.692307692307692 5.4 5 4 lymphoid hypoplasia 0.136927536031949 0.315231139175819 0.68613145277073 0.692307692307692 5.4 5 4 abnormal bile duct development 0.136927536031949 0.315231139175819 0.68613145277073 0.692307692307692 5.4 5 4 abnormal coping response 0.136927536031949 0.315231139175819 0.68613145277073 0.692307692307692 5.4 5 4 abnormal soleus morphology 0.136927536031949 0.315231139175819 0.68613145277073 0.692307692307692 5.4 5 4 muscle fatigue 0.136927536031949 0.315231139175819 0.68613145277073 0.692307692307692 5.4 5 4 increased circulating thyroid-stimulating hormone level 0.136927536031949 0.315231139175819 0.68613145277073 0.692307692307692 5.4 5 4 increased circulating thyroxine level 0.136927536031949 0.315231139175819 0.68613145277073 0.692307692307692 5.4 5 4 decreased cardiac stroke volume 0.136927536031949 0.315231139175819 0.68613145277073 0.692307692307692 5.4 5 4 small ovary 0.000180697847677177 0.00176962951219283 0.68613145277073 0.692307692307692 5.4 5 4 abnormal iris morphology 0.0126977448241643 0.0587093684946259 0.68613145277073 0.692307692307692 5.4 5 4 abnormal circulating hormone level 0.0126977448241643 0.0587093684946259 0.68613145277073 0.692307692307692 5.4 5 4 decreased circulating alanine transaminase level 0.00122267031796027 0.00911961743905897 0.685010322945941 0.691176470588235 5.4 5 4 abnormal joint morphology 0.00354237934675157 0.0216769215868254 0.684745328623718 0.690909090909091 5.4 5 4 atelectasis 0.00102190610184583 0.00777367409278748 0.683983936486627 0.690140845070423 5.4 5 4 enlarged liver 0.000106883138478125 0.00113389448432963 0.683844347928161 0.69 5.4 5 4 abnormal metabolism 0.00869328796972795 0.0435978907756014 0.682743149300257 0.688888888888889 5.4 5 4 increased double-negative T cell number 0.00245761222515646 0.0155951796175426 0.682382100569797 0.688524590163934 5.4 5 4 abnormal lymph node morphology 0.00720410081438385 0.0376389918306874 0.681366651015377 0.6875 5.4 5 4 abnormal osteoclast morphology 0.00720410081438385 0.0376389918306874 0.681366651015377 0.6875 5.4 5 4 polydipsia 0.0265132333797881 0.104436528950472 0.681366651015377 0.6875 5.4 5 4 abnormal embryonic hematopoiesis 0.0265132333797881 0.104436528950472 0.681366651015377 0.6875 5.4 5 4 bradykinesia 0.0265132333797881 0.104436528950472 0.681366651015377 0.6875 5.4 5 4 increased fatty acid level 0.0265132333797881 0.104436528950472 0.681366651015377 0.6875 5.4 5 4 absent mandible 0.108324130572522 0.287483757473172 0.681366651015377 0.6875 5.4 5 4 disorganized retinal layers 0.108324130572522 0.287483757473172 0.681366651015377 0.6875 5.4 5 4 reduced male mating frequency 0.108324130572522 0.287483757473172 0.681366651015377 0.6875 5.4 5 4 intraventricular hemorrhage 0.108324130572522 0.287483757473172 0.681366651015377 0.6875 5.4 5 4 abnormal meiosis 0.108324130572522 0.287483757473172 0.681366651015377 0.6875 5.4 5 4 decreased cochlear coiling 0.108324130572522 0.287483757473172 0.681366651015377 0.6875 5.4 5 4 large intestinal inflammation 0.108324130572522 0.287483757473172 0.681366651015377 0.6875 5.4 5 4 bowed radius 0.108324130572522 0.287483757473172 0.681366651015377 0.6875 5.4 5 4 decreased circulating prolactin level 0.108324130572522 0.287483757473172 0.681366651015377 0.6875 5.4 5 4 decreased creatinine clearance 0.108324130572522 0.287483757473172 0.681366651015377 0.6875 5.4 5 4 abnormal thoracic cage shape 0.108324130572522 0.287483757473172 0.681366651015377 0.6875 5.4 5 4 increased heart left ventricle size 0.108324130572522 0.287483757473172 0.681366651015377 0.6875 5.4 5 4 decreased midbrain size 0.108324130572522 0.287483757473172 0.681366651015377 0.6875 5.4 5 4 increased kidney weight 0.00597542991321349 0.0329211116481031 0.68015209370519 0.686274509803922 5.4 5 4 impaired fertilization 0.00142507241733352 0.0101281932517633 0.679596867506246 0.685714285714286 5.4 5 4 abnormal cochlea morphology 0.00496043050556934 0.0278397952806434 0.679072487207245 0.685185185185185 5.4 5 4 diluted coat color 0.00496043050556934 0.0278397952806434 0.679072487207245 0.685185185185185 5.4 5 4 abnormal small intestine morphology 0.00496043050556934 0.0278397952806434 0.679072487207245 0.685185185185185 5.4 5 4 increased bone marrow cell number 0.0179062905109685 0.076796375251783 0.678106523498557 0.684210526315789 5.4 5 4 short vibrissae 0.0865289846156305 0.244037244026509 0.678106523498557 0.684210526315789 5.4 5 4 delayed sexual maturation 0.0865289846156305 0.244037244026509 0.678106523498557 0.684210526315789 5.4 5 4 abnormal ear morphology 0.0865289846156305 0.244037244026509 0.678106523498557 0.684210526315789 5.4 5 4 abnormal neurotransmitter level 0.0865289846156305 0.244037244026509 0.678106523498557 0.684210526315789 5.4 5 4 increased susceptibility to ischemic brain injury 0.0865289846156305 0.244037244026509 0.678106523498557 0.684210526315789 5.4 5 4 decreased eye pigmentation 0.0865289846156305 0.244037244026509 0.678106523498557 0.684210526315789 5.4 5 4 increased liver cholesterol level 0.0865289846156305 0.244037244026509 0.678106523498557 0.684210526315789 5.4 5 4 decreased circulating magnesium level 0.0865289846156305 0.244037244026509 0.678106523498557 0.684210526315789 5.4 5 4 short humerus 0.0147552660011291 0.0670387656215684 0.676834278613945 0.682926829268293 5.4 5 4 short femur 0.000484053916709091 0.0042100843280205 0.675735521668143 0.681818181818182 5.4 5 4 osteoporosis 0.0121771217613281 0.0564070584381818 0.675735521668143 0.681818181818182 5.4 5 4 abnormal gametogenesis 0.0121771217613281 0.0564070584381818 0.675735521668143 0.681818181818182 5.4 5 4 cochlear hair cell degeneration 0.0121771217613281 0.0564070584381818 0.675735521668143 0.681818181818182 5.4 5 4 abnormal abdominal fat pad morphology 0.0696120894707772 0.201935944674703 0.675735521668143 0.681818181818182 5.4 5 4 abnormal long bone epiphysis morphology 0.0696120894707772 0.201935944674703 0.675735521668143 0.681818181818182 5.4 5 4 abnormal enterocyte morphology 0.0696120894707772 0.201935944674703 0.675735521668143 0.681818181818182 5.4 5 4 intracerebral hemorrhage 0.0696120894707772 0.201935944674703 0.675735521668143 0.681818181818182 5.4 5 4 testis hypoplasia 0.0696120894707772 0.201935944674703 0.675735521668143 0.681818181818182 5.4 5 4 abnormal lysosome physiology 0.0696120894707772 0.201935944674703 0.675735521668143 0.681818181818182 5.4 5 4 decreased circulating estradiol level 0.0696120894707772 0.201935944674703 0.675735521668143 0.681818181818182 5.4 5 4 abnormal mesenteric lymph node morphology 0.0696120894707772 0.201935944674703 0.675735521668143 0.681818181818182 5.4 5 4 abnormal sperm midpiece morphology 0.0696120894707772 0.201935944674703 0.675735521668143 0.681818181818182 5.4 5 4 impaired humoral immune response 0.0696120894707772 0.201935944674703 0.675735521668143 0.681818181818182 5.4 5 4 hepatic necrosis 0.0100629496559229 0.0494882506639985 0.674777031566486 0.680851063829787 5.4 5 4 increased systemic arterial blood pressure 0.0100629496559229 0.0494882506639985 0.674777031566486 0.680851063829787 5.4 5 4 decreased respiratory quotient 0.00832582925930091 0.0418816992568474 0.673933560277028 0.68 5.4 5 4 abnormal inner ear vestibule morphology 0.0563095751853777 0.182501717620361 0.673933560277028 0.68 5.4 5 4 decreased placenta weight 0.0563095751853777 0.182501717620361 0.673933560277028 0.68 5.4 5 4 decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 0.0563095751853777 0.182501717620361 0.673933560277028 0.68 5.4 5 4 abnormal stomach mucosa morphology 0.0563095751853777 0.182501717620361 0.673933560277028 0.68 5.4 5 4 abnormal lens morphology 3.52195523951091e-05 0.000432635242384365 0.67362384816293 0.6796875 5.4 5 4 abnormal placenta development 0.00689602798616959 0.036113409717046 0.673185576303358 0.679245283018868 5.4 5 4 abnormal renal glomerulus morphology 0.000139121650353302 0.00143595479358439 0.67284246438883 0.678899082568807 5.4 5 4 abnormal respiration 0.0457476945942364 0.155037316489323 0.672517733469723 0.678571428571429 5.4 5 4 abnormal retinal photoreceptor morphology 0.030500970997881 0.116724869780352 0.670435635223687 0.676470588235294 5.4 5 4 decreased regulatory T cell number 0.030500970997881 0.116724869780352 0.670435635223687 0.676470588235294 5.4 5 4 increased susceptibility to weight gain 0.030500970997881 0.116724869780352 0.670435635223687 0.676470588235294 5.4 5 4 abnormal long bone metaphysis morphology 0.0250044480464122 0.0994381527025587 0.669647814265727 0.675675675675676 5.4 5 4 decreased circulating chloride level 0.0250044480464122 0.0994381527025587 0.669647814265727 0.675675675675676 5.4 5 4 abnormal hair follicle development 0.0250044480464122 0.0994381527025587 0.669647814265727 0.675675675675676 5.4 5 4 decreased neutrophil cell number 0.000111659357680252 0.00117691801792215 0.669189935418366 0.675213675213675 5.4 5 4 impaired ovarian folliculogenesis 0.0205426123960026 0.0830890216830186 0.668978166451461 0.675 5.4 5 4 increased susceptibility to weight loss 0.0205426123960026 0.0830890216830186 0.668978166451461 0.675 5.4 5 4 impaired macrophage phagocytosis 0.0169085322255508 0.0726424419880098 0.668401957867093 0.674418604651163 5.4 5 4 increased susceptibility to injury 0.00951508011964962 0.0472430375202164 0.667072245749321 0.673076923076923 5.4 5 4 abnormal femur morphology 0.00373099758874316 0.0227471973088201 0.665649916867126 0.671641791044776 5.4 5 4 abnormal placenta labyrinth morphology 0.0017884078022944 0.0122552246017582 0.66490094368359 0.670886075949367 5.4 5 4 abnormal response to infection 0.0017884078022944 0.0122552246017582 0.66490094368359 0.670886075949367 5.4 5 4 decreased food intake 0.0017884078022944 0.0122552246017582 0.66490094368359 0.670886075949367 5.4 5 4 decreased T cell number 1.07532648286864e-05 0.000155969365955437 0.664823022560459 0.670807453416149 5.4 5 4 sparse hair 0.00149020708976696 0.0104862521521791 0.664747952210124 0.670731707317073 5.4 5 4 increased T cell number 0.00103617250329189 0.00787016519675902 0.664473262973674 0.670454545454545 5.4 5 4 cataract 0.000144092646496696 0.00148418409176204 0.663449421274177 0.669421487603306 5.4 5 4 decreased T cell proliferation 2.93108715295252e-05 0.000371411706545666 0.66295133612307 0.668918918918919 5.4 5 4 head tossing 0.0422675512226264 0.14363460883372 0.660719176742184 0.666666666666667 5.4 5 4 spleen hypoplasia 0.00047505100649616 0.00414627852161122 0.660719176742184 0.666666666666667 5.4 5 4 deafness 0.000680663050131088 0.00562508085448864 0.660719176742184 0.666666666666667 5.4 5 4 arrest of spermatogenesis 0.00168389889951654 0.0117495049440319 0.660719176742184 0.666666666666667 5.4 5 4 impaired hematopoiesis 0.0130266279514757 0.0598960019025801 0.660719176742184 0.666666666666667 5.4 5 4 emphysema 0.0518508989790366 0.17231678184416 0.660719176742184 0.666666666666667 5.4 5 4 abnormal spleen marginal zone morphology 0.0518508989790366 0.17231678184416 0.660719176742184 0.666666666666667 5.4 5 4 abnormal trigeminal ganglion morphology 0.0638304962328274 0.186639416788461 0.660719176742184 0.666666666666667 5.4 5 4 abnormal primitive streak formation 0.0789134998295386 0.224083710988559 0.660719176742184 0.666666666666667 5.4 5 4 increased circulating total protein level 0.0789134998295386 0.224083710988559 0.660719176742184 0.666666666666667 5.4 5 4 abnormal cellular extravasation 0.0789134998295386 0.224083710988559 0.660719176742184 0.666666666666667 5.4 5 4 abnormal eye pigmentation 0.098079119235355 0.266490233859034 0.660719176742184 0.666666666666667 5.4 5 4 abnormal stapes morphology 0.098079119235355 0.266490233859034 0.660719176742184 0.666666666666667 5.4 5 4 abnormal epidermis stratum spinosum morphology 0.154967798850559 0.34479642186115 0.660719176742184 0.666666666666667 5.4 5 4 altered righting response 0.154967798850559 0.34479642186115 0.660719176742184 0.666666666666667 5.4 5 4 increased alcohol consumption 0.154967798850559 0.34479642186115 0.660719176742184 0.666666666666667 5.4 5 4 abnormal pericyte morphology 0.154967798850559 0.34479642186115 0.660719176742184 0.666666666666667 5.4 5 4 abnormal ear development 0.154967798850559 0.34479642186115 0.660719176742184 0.666666666666667 5.4 5 4 abnormal energy homeostasis 0.154967798850559 0.34479642186115 0.660719176742184 0.666666666666667 5.4 5 4 abnormal dendritic cell morphology 0.154967798850559 0.34479642186115 0.660719176742184 0.666666666666667 5.4 5 4 abnormal mineral level 0.198165955102027 0.408737821986975 0.660719176742184 0.666666666666667 5.4 5 4 amyloidosis 0.198165955102027 0.408737821986975 0.660719176742184 0.666666666666667 5.4 5 4 abnormal superior cervical ganglion morphology 0.198165955102027 0.408737821986975 0.660719176742184 0.666666666666667 5.4 5 4 abnormal glossopharyngeal nerve morphology 0.198165955102027 0.408737821986975 0.660719176742184 0.666666666666667 5.4 5 4 absent optic nerve 0.198165955102027 0.408737821986975 0.660719176742184 0.666666666666667 5.4 5 4 abnormal pilomotor reflex 0.198165955102027 0.408737821986975 0.660719176742184 0.666666666666667 5.4 5 4 myocarditis 0.198165955102027 0.408737821986975 0.660719176742184 0.666666666666667 5.4 5 4 interstitial pneumonia 0.198165955102027 0.408737821986975 0.660719176742184 0.666666666666667 5.4 5 4 increased litter size 0.198165955102027 0.408737821986975 0.660719176742184 0.666666666666667 5.4 5 4 altered tumor susceptibility 0.198165955102027 0.408737821986975 0.660719176742184 0.666666666666667 5.4 5 4 abnormal tracheal ciliated epithelium morphology 0.198165955102027 0.408737821986975 0.660719176742184 0.666666666666667 5.4 5 4 absent tail 0.198165955102027 0.408737821986975 0.660719176742184 0.666666666666667 5.4 5 4 impaired sperm capacitation 0.198165955102027 0.408737821986975 0.660719176742184 0.666666666666667 5.4 5 4 abnormal nucleotide metabolism 0.198165955102027 0.408737821986975 0.660719176742184 0.666666666666667 5.4 5 4 increased hepatocyte proliferation 0.198165955102027 0.408737821986975 0.660719176742184 0.666666666666667 5.4 5 4 vestibular saccular macula degeneration 0.198165955102027 0.408737821986975 0.660719176742184 0.666666666666667 5.4 5 4 bowed ulna 0.198165955102027 0.408737821986975 0.660719176742184 0.666666666666667 5.4 5 4 hematuria 0.198165955102027 0.408737821986975 0.660719176742184 0.666666666666667 5.4 5 4 abnormal patella morphology 0.198165955102027 0.408737821986975 0.660719176742184 0.666666666666667 5.4 5 4 hydrometra 0.198165955102027 0.408737821986975 0.660719176742184 0.666666666666667 5.4 5 4 increased type II pneumocyte number 0.198165955102027 0.408737821986975 0.660719176742184 0.666666666666667 5.4 5 4 decreased compensatory feeding amount 0.198165955102027 0.408737821986975 0.660719176742184 0.666666666666667 5.4 5 4 abnormal cartilage development 0.0191447893445284 0.0802403765703698 0.660719176742184 0.666666666666667 5.4 5 4 decreased osteoclast cell number 0.0191447893445284 0.0802403765703698 0.660719176742184 0.666666666666667 5.4 5 4 abnormal leukocyte adhesion 0.0283233818845767 0.110171090598725 0.660719176742184 0.666666666666667 5.4 5 4 increased autoantibody level 0.0283233818845767 0.110171090598725 0.660719176742184 0.666666666666667 5.4 5 4 decreased B-1 B cell number 0.0283233818845767 0.110171090598725 0.660719176742184 0.666666666666667 5.4 5 4 abnormal stomach glandular epithelium morphology 0.122729524455818 0.294493642506925 0.660719176742184 0.666666666666667 5.4 5 4 cortical renal glomerulopathies 0.122729524455818 0.294493642506925 0.660719176742184 0.666666666666667 5.4 5 4 abnormal mammary gland morphology 0.122729524455818 0.294493642506925 0.660719176742184 0.666666666666667 5.4 5 4 eye inflammation 0.122729524455818 0.294493642506925 0.660719176742184 0.666666666666667 5.4 5 4 abnormal Peyer's patch follicle morphology 0.122729524455818 0.294493642506925 0.660719176742184 0.666666666666667 5.4 5 4 abnormal redox activity 0.122729524455818 0.294493642506925 0.660719176742184 0.666666666666667 5.4 5 4 long tibia 0.122729524455818 0.294493642506925 0.660719176742184 0.666666666666667 5.4 5 4 abnormal neutrophil morphology 0.122729524455818 0.294493642506925 0.660719176742184 0.666666666666667 5.4 5 4 increased susceptibility to autoimmune disorder 0.122729524455818 0.294493642506925 0.660719176742184 0.666666666666667 5.4 5 4 decreased tumor latency 0.122729524455818 0.294493642506925 0.660719176742184 0.666666666666667 5.4 5 4 decreased fluid intake 0.122729524455818 0.294493642506925 0.660719176742184 0.666666666666667 5.4 5 4 increased adipocyte glucose uptake 0.122729524455818 0.294493642506925 0.660719176742184 0.666666666666667 5.4 5 4 crypts of Lieberkuhn abscesses 0.258307790863014 0.456836565781549 0.660719176742184 0.666666666666667 5.4 5 4 renal tubular acidosis 0.258307790863014 0.456836565781549 0.660719176742184 0.666666666666667 5.4 5 4 abnormal urinary bladder urothelium morphology 0.258307790863014 0.456836565781549 0.660719176742184 0.666666666666667 5.4 5 4 synostosis 0.258307790863014 0.456836565781549 0.660719176742184 0.666666666666667 5.4 5 4 deformed nails 0.258307790863014 0.456836565781549 0.660719176742184 0.666666666666667 5.4 5 4 abnormal sympathetic neuron morphology 0.258307790863014 0.456836565781549 0.660719176742184 0.666666666666667 5.4 5 4 dilated uterus 0.258307790863014 0.456836565781549 0.660719176742184 0.666666666666667 5.4 5 4 abnormal vagina epithelium morphology 0.258307790863014 0.456836565781549 0.660719176742184 0.666666666666667 5.4 5 4 abnormal lung volume 0.258307790863014 0.456836565781549 0.660719176742184 0.666666666666667 5.4 5 4 abnormal thymus lobule morphology 0.258307790863014 0.456836565781549 0.660719176742184 0.666666666666667 5.4 5 4 polycythemia 0.258307790863014 0.456836565781549 0.660719176742184 0.666666666666667 5.4 5 4 abnormal postural reflex 0.258307790863014 0.456836565781549 0.660719176742184 0.666666666666667 5.4 5 4 decreased circulating bicarbonate level 0.258307790863014 0.456836565781549 0.660719176742184 0.666666666666667 5.4 5 4 enlarged otoliths 0.258307790863014 0.456836565781549 0.660719176742184 0.666666666666667 5.4 5 4 abnormal lens capsule morphology 0.258307790863014 0.456836565781549 0.660719176742184 0.666666666666667 5.4 5 4 abnormal abdominal wall morphology 0.258307790863014 0.456836565781549 0.660719176742184 0.666666666666667 5.4 5 4 abnormal artery development 0.258307790863014 0.456836565781549 0.660719176742184 0.666666666666667 5.4 5 4 decreased muscle weight 0.258307790863014 0.456836565781549 0.660719176742184 0.666666666666667 5.4 5 4 small scapula 0.258307790863014 0.456836565781549 0.660719176742184 0.666666666666667 5.4 5 4 abnormal hair cell mechanoelectric transduction 0.258307790863014 0.456836565781549 0.660719176742184 0.666666666666667 5.4 5 4 abnormal gallbladder physiology 0.258307790863014 0.456836565781549 0.660719176742184 0.666666666666667 5.4 5 4 abnormal posterior eye segment morphology 0.258307790863014 0.456836565781549 0.660719176742184 0.666666666666667 5.4 5 4 hemothorax 0.258307790863014 0.456836565781549 0.660719176742184 0.666666666666667 5.4 5 4 abnormal oxygen consumption 0.258307790863014 0.456836565781549 0.660719176742184 0.666666666666667 5.4 5 4 decreased susceptibility to atherosclerosis 0.258307790863014 0.456836565781549 0.660719176742184 0.666666666666667 5.4 5 4 abnormal hyoid bone lesser horn morphology 0.258307790863014 0.456836565781549 0.660719176742184 0.666666666666667 5.4 5 4 decreased airway resistance 0.258307790863014 0.456836565781549 0.660719176742184 0.666666666666667 5.4 5 4 decreased pancreatic beta cell proliferation 0.258307790863014 0.456836565781549 0.660719176742184 0.666666666666667 5.4 5 4 increased bone mineralization 0.258307790863014 0.456836565781549 0.660719176742184 0.666666666666667 5.4 5 4 increased inflammatory response 0.0010975239253024 0.0082730023157264 0.657241707390909 0.663157894736842 5.4 5 4 obese 0.00327545753613188 0.0204459237669462 0.656428792477625 0.662337662337662 5.4 5 4 increased granulocyte number 0.00393764909529979 0.0232119232861295 0.656254857980412 0.662162162162162 5.4 5 4 decreased monocyte cell number 0.00686979008202818 0.0360139153404533 0.655636721536475 0.661538461538462 5.4 5 4 increased body length 0.0176898313115636 0.0759334864322942 0.654111984974762 0.66 5.4 5 4 abnormal tibia morphology 0.0214522860709078 0.0866275350671804 0.653690249330033 0.659574468085106 5.4 5 4 abnormal circadian rhythm 0.0260559257897146 0.102961263545536 0.653211004279205 0.659090909090909 5.4 5 4 scaly skin 0.0317039233004013 0.117469789581114 0.652661625806304 0.658536585365854 5.4 5 4 abnormal compact bone morphology 0.0386547509991889 0.133454119514896 0.652025503363997 0.657894736842105 5.4 5 4 abnormal dermal layer morphology 0.0472401378847335 0.159877337399013 0.651280331360153 0.657142857142857 5.4 5 4 maternal effect 0.00765832960385713 0.0396876976866554 0.650857696492301 0.656716417910448 5.4 5 4 decreased eosinophil cell number 0.00922962719969374 0.0458715237946817 0.650395439605587 0.65625 5.4 5 4 abnormal male meiosis 0.011133040916709 0.0528500749624308 0.649887714828378 0.655737704918033 5.4 5 4 glomerulosclerosis 0.0134418651417252 0.0616912168635452 0.649327466798353 0.655172413793103 5.4 5 4 thrombocytosis 0.0134418651417252 0.0616912168635452 0.649327466798353 0.655172413793103 5.4 5 4 focal hair loss 0.0711711662395249 0.2062181432974 0.649327466798353 0.655172413793103 5.4 5 4 decreased retinal photoreceptor cell number 0.0711711662395249 0.2062181432974 0.649327466798353 0.655172413793103 5.4 5 4 abnormal stomach morphology 0.0878382015044846 0.247589264863916 0.648013038727911 0.653846153846154 5.4 5 4 increased urine protein level 0.00487792982452252 0.027545630961407 0.648013038727911 0.653846153846154 5.4 5 4 abnormal T cell differentiation 0.00151440999039687 0.010641510878848 0.647635628687883 0.653465346534653 5.4 5 4 abnormal respiratory system physiology 0.0238202847638127 0.0949566640224106 0.647235111910711 0.653061224489796 5.4 5 4 increased fluid intake 0.0238202847638127 0.0949566640224106 0.647235111910711 0.653061224489796 5.4 5 4 hypotension 0.10892282233192 0.287483757473172 0.646355716378224 0.652173913043478 5.4 5 4 conjunctivitis 0.10892282233192 0.287483757473172 0.646355716378224 0.652173913043478 5.4 5 4 decreased epididymis weight 0.10892282233192 0.287483757473172 0.646355716378224 0.652173913043478 5.4 5 4 increased susceptibility to fungal infection 0.10892282233192 0.287483757473172 0.646355716378224 0.652173913043478 5.4 5 4 abnormal hepatocyte physiology 0.10892282233192 0.287483757473172 0.646355716378224 0.652173913043478 5.4 5 4 decreased circulating phosphate level 0.0427733823633576 0.145254318947238 0.644201197323629 0.65 5.4 5 4 abnormal cell proliferation 0.135871295842637 0.314692596283575 0.644201197323629 0.65 5.4 5 4 abnormal hair texture 0.135871295842637 0.314692596283575 0.644201197323629 0.65 5.4 5 4 enhanced behavioral response to xenobiotic 0.135871295842637 0.314692596283575 0.644201197323629 0.65 5.4 5 4 decreased muscle cell glucose uptake 0.135871295842637 0.314692596283575 0.644201197323629 0.65 5.4 5 4 abnormal pancreatic beta cell physiology 0.0521919298943457 0.173218713291775 0.642861901695098 0.648648648648649 5.4 5 4 skin inflammation 0.0521919298943457 0.173218713291775 0.642861901695098 0.648648648648649 5.4 5 4 increased liver weight 0.00411613651732291 0.0235681430385928 0.641948745584736 0.647727272727273 5.4 5 4 abnormal trabecular bone morphology 0.000990376912207029 0.00769863302848433 0.641286259779179 0.647058823529412 5.4 5 4 thin skin 0.0638396149679931 0.186639416788461 0.641286259779179 0.647058823529412 5.4 5 4 decreased pancreatic beta cell number 0.0638396149679931 0.186639416788461 0.641286259779179 0.647058823529412 5.4 5 4 increased width of hypertrophic chondrocyte zone 0.0638396149679931 0.186639416788461 0.641286259779179 0.647058823529412 5.4 5 4 increased incidence of corneal inflammation 0.170787138982605 0.377965309803586 0.641286259779179 0.647058823529412 5.4 5 4 abnormal duodenum morphology 0.170787138982605 0.377965309803586 0.641286259779179 0.647058823529412 5.4 5 4 abnormal melanosome morphology 0.170787138982605 0.377965309803586 0.641286259779179 0.647058823529412 5.4 5 4 decreased growth hormone level 0.170787138982605 0.377965309803586 0.641286259779179 0.647058823529412 5.4 5 4 abnormal tendon morphology 0.170787138982605 0.377965309803586 0.641286259779179 0.647058823529412 5.4 5 4 abnormal survival 0.170787138982605 0.377965309803586 0.641286259779179 0.647058823529412 5.4 5 4 delayed heart development 0.170787138982605 0.377965309803586 0.641286259779179 0.647058823529412 5.4 5 4 abnormal response/metabolism to endogenous compounds 0.00591828136162415 0.0326424055145013 0.640575299402483 0.646341463414634 5.4 5 4 abnormal kidney physiology 0.0317946861114429 0.117469789581114 0.640071702468991 0.645833333333333 5.4 5 4 abnormal retinal photoreceptor layer morphology 0.0783086492249571 0.222747587132168 0.639405654911791 0.645161290322581 5.4 5 4 abnormal intestine physiology 0.0783086492249571 0.222747587132168 0.639405654911791 0.645161290322581 5.4 5 4 albuminuria 0.0385823605966147 0.13329669720011 0.638695204184111 0.644444444444444 5.4 5 4 increased triglyceride level 0.0963795391822911 0.262302082840207 0.637122063287106 0.642857142857143 5.4 5 4 absent visceral yolk sac blood islands 0.216887275337334 0.445321582667452 0.637122063287106 0.642857142857143 5.4 5 4 decreased vascular permeability 0.216887275337334 0.445321582667452 0.637122063287106 0.642857142857143 5.4 5 4 abnormal uterus development 0.216887275337334 0.445321582667452 0.637122063287106 0.642857142857143 5.4 5 4 vascular smooth muscle hypoplasia 0.216887275337334 0.445321582667452 0.637122063287106 0.642857142857143 5.4 5 4 enlarged stomach 0.216887275337334 0.445321582667452 0.637122063287106 0.642857142857143 5.4 5 4 abnormal maternal decidual layer morphology 0.216887275337334 0.445321582667452 0.637122063287106 0.642857142857143 5.4 5 4 abnormal squamosal bone morphology 0.216887275337334 0.445321582667452 0.637122063287106 0.642857142857143 5.4 5 4 increased stomach tumor incidence 0.216887275337334 0.445321582667452 0.637122063287106 0.642857142857143 5.4 5 4 abnormal vibrissa morphology 0.04689513844416 0.158817776555273 0.637122063287106 0.642857142857143 5.4 5 4 liver inflammation 0.00141232003775962 0.0100519201542977 0.635942207614352 0.641666666666667 5.4 5 4 increased sensitivity to induced morbidity/mortality 9.4853312876104e-05 0.00103485796394434 0.635583121105253 0.641304347826087 5.4 5 4 acanthosis 0.0571036244181387 0.184714259740078 0.635306900713638 0.641025641025641 5.4 5 4 increased vascular permeability 0.0571036244181387 0.184714259740078 0.635306900713638 0.641025641025641 5.4 5 4 abnormal response to injury 0.0571036244181387 0.184714259740078 0.635306900713638 0.641025641025641 5.4 5 4 increased pre-B cell number 0.119098254752492 0.294493642506925 0.634290409672497 0.64 5.4 5 4 decreased acute inflammation 0.119098254752492 0.294493642506925 0.634290409672497 0.64 5.4 5 4 dermatitis 0.0258588156107604 0.102263599096608 0.632239901882607 0.637931034482759 5.4 5 4 abnormal enzyme/coenzyme level 0.0258588156107604 0.102263599096608 0.632239901882607 0.637931034482759 5.4 5 4 hyperkeratosis 0.0161025692442991 0.0695152957111566 0.631992256014263 0.63768115942029 5.4 5 4 abnormal coat appearance 0.0161025692442991 0.0695152957111566 0.631992256014263 0.63768115942029 5.4 5 4 abnormal skin morphology 0.019351439733281 0.0810382261557852 0.630686486890267 0.636363636363636 5.4 5 4 abnormal epidermis stratum basale morphology 0.0852304008667597 0.241607546616598 0.630686486890267 0.636363636363636 5.4 5 4 myeloid hyperplasia 0.0852304008667597 0.241607546616598 0.630686486890267 0.636363636363636 5.4 5 4 abnormal photoreceptor outer segment morphology 0.0510056971746512 0.169848288784397 0.630686486890267 0.636363636363636 5.4 5 4 decreased sensitivity to induced morbidity/mortality 0.0510056971746512 0.169848288784397 0.630686486890267 0.636363636363636 5.4 5 4 abnormal facial nerve morphology 0.147896421323366 0.330541193209229 0.630686486890267 0.636363636363636 5.4 5 4 increased myocardial infarction size 0.147896421323366 0.330541193209229 0.630686486890267 0.636363636363636 5.4 5 4 parakeratosis 0.147896421323366 0.330541193209229 0.630686486890267 0.636363636363636 5.4 5 4 abnormal retinal layer morphology 0.147896421323366 0.330541193209229 0.630686486890267 0.636363636363636 5.4 5 4 abnormal thrombopoiesis 0.2794576102213 0.490752421761725 0.630686486890267 0.636363636363636 5.4 5 4 abnormal stomach epithelium morphology 0.2794576102213 0.490752421761725 0.630686486890267 0.636363636363636 5.4 5 4 abnormal sebaceous gland morphology 0.2794576102213 0.490752421761725 0.630686486890267 0.636363636363636 5.4 5 4 abnormal glossopharyngeal ganglion morphology 0.2794576102213 0.490752421761725 0.630686486890267 0.636363636363636 5.4 5 4 focal hepatic necrosis 0.2794576102213 0.490752421761725 0.630686486890267 0.636363636363636 5.4 5 4 abnormal primary sex determination 0.2794576102213 0.490752421761725 0.630686486890267 0.636363636363636 5.4 5 4 abnormal larynx morphology 0.2794576102213 0.490752421761725 0.630686486890267 0.636363636363636 5.4 5 4 decreased post-tetanic potentiation 0.2794576102213 0.490752421761725 0.630686486890267 0.636363636363636 5.4 5 4 retinal detachment 0.2794576102213 0.490752421761725 0.630686486890267 0.636363636363636 5.4 5 4 pathological neovascularization 0.2794576102213 0.490752421761725 0.630686486890267 0.636363636363636 5.4 5 4 abnormal Bruch membrane morphology 0.2794576102213 0.490752421761725 0.630686486890267 0.636363636363636 5.4 5 4 abnormal aorta smooth muscle morphology 0.2794576102213 0.490752421761725 0.630686486890267 0.636363636363636 5.4 5 4 increased number of Howell-Jolly bodies 0.2794576102213 0.490752421761725 0.630686486890267 0.636363636363636 5.4 5 4 abnormal extraembryonic ectoderm morphology 0.2794576102213 0.490752421761725 0.630686486890267 0.636363636363636 5.4 5 4 increased pancreatic beta cell proliferation 0.2794576102213 0.490752421761725 0.630686486890267 0.636363636363636 5.4 5 4 decreased IgA level 0.0376665655059919 0.130223185123217 0.628953831706502 0.634615384615385 5.4 5 4 abnormal hair growth 0.0376665655059919 0.130223185123217 0.628953831706502 0.634615384615385 5.4 5 4 abnormal leukocyte migration 0.0376665655059919 0.130223185123217 0.628953831706502 0.634615384615385 5.4 5 4 decreased body temperature 0.0376665655059919 0.130223185123217 0.628953831706502 0.634615384615385 5.4 5 4 arrested B cell differentiation 0.0619604447391489 0.186639416788461 0.628488972998663 0.634146341463415 5.4 5 4 increased tumor growth/size 0.0619604447391489 0.186639416788461 0.628488972998663 0.634146341463415 5.4 5 4 increased metastatic potential 0.104542536962186 0.28343276369857 0.627683217905075 0.633333333333333 5.4 5 4 abnormal pain threshold 0.104542536962186 0.28343276369857 0.627683217905075 0.633333333333333 5.4 5 4 increased B cell number 0.00304000443649823 0.0191201290411867 0.626836142037457 0.632478632478632 5.4 5 4 irregular coat pigmentation 0.184787592753283 0.396446877399224 0.625944483229438 0.631578947368421 5.4 5 4 abnormal neural crest cell migration 0.184787592753283 0.396446877399224 0.625944483229438 0.631578947368421 5.4 5 4 abnormal optic vesicle formation 0.184787592753283 0.396446877399224 0.625944483229438 0.631578947368421 5.4 5 4 osteoarthritis 0.184787592753283 0.396446877399224 0.625944483229438 0.631578947368421 5.4 5 4 oliguria 0.184787592753283 0.396446877399224 0.625944483229438 0.631578947368421 5.4 5 4 increased circulating VLDL cholesterol level 0.184787592753283 0.396446877399224 0.625944483229438 0.631578947368421 5.4 5 4 decreased inflammatory response 0.0118188714138841 0.0553140971628161 0.625323506559567 0.630952380952381 5.4 5 4 decreased IgG level 0.00430419052356159 0.0245003980031109 0.625004626648012 0.630630630630631 5.4 5 4 abnormal inner ear morphology 0.0550934441303291 0.182501717620361 0.624810525832283 0.630434782608696 5.4 5 4 abnormal lymphocyte physiology 0.0550934441303291 0.182501717620361 0.624810525832283 0.630434782608696 5.4 5 4 polyphagia 0.0406295411866959 0.13825715964693 0.624012555812063 0.62962962962963 5.4 5 4 wrinkled skin 0.128651300466302 0.29866552488094 0.624012555812063 0.62962962962963 5.4 5 4 abnormal single cell response 0.128651300466302 0.29866552488094 0.624012555812063 0.62962962962963 5.4 5 4 thick epidermis 0.022523589133828 0.0902940015638955 0.622963795214059 0.628571428571429 5.4 5 4 abnormal intestinal goblet cell morphology 0.0919310377242784 0.251896363839265 0.622963795214059 0.628571428571429 5.4 5 4 impaired adaptive thermogenesis 0.0919310377242784 0.251896363839265 0.622963795214059 0.628571428571429 5.4 5 4 abnormal thrombosis 0.0490006896594654 0.163829590763334 0.621853342816173 0.627450980392157 5.4 5 4 abnormal colon morphology 0.0362584107765077 0.125704246420297 0.621523971342224 0.627118644067797 5.4 5 4 increased B cell proliferation 0.0362584107765077 0.125704246420297 0.621523971342224 0.627118644067797 5.4 5 4 abnormal dendritic cell physiology 0.00653588803073106 0.0351145172277398 0.620582030491491 0.626168224299065 5.4 5 4 abnormal intestinal epithelium morphology 0.0591490207435829 0.186639416788461 0.619424228195798 0.625 5.4 5 4 curly vibrissae 0.158938359835889 0.353314718580674 0.619424228195798 0.625 5.4 5 4 hypopigmentation 0.158938359835889 0.353314718580674 0.619424228195798 0.625 5.4 5 4 abnormal lymphatic vessel morphology 0.112339055202093 0.289428689606635 0.619424228195798 0.625 5.4 5 4 abnormal diaphragm morphology 0.112339055202093 0.289428689606635 0.619424228195798 0.625 5.4 5 4 delayed hair appearance 0.23270724598062 0.451559484641431 0.619424228195798 0.625 5.4 5 4 white spotting 0.23270724598062 0.451559484641431 0.619424228195798 0.625 5.4 5 4 paternal imprinting 0.23270724598062 0.451559484641431 0.619424228195798 0.625 5.4 5 4 abnormal epididymis epithelium morphology 0.23270724598062 0.451559484641431 0.619424228195798 0.625 5.4 5 4 increased thymus weight 0.23270724598062 0.451559484641431 0.619424228195798 0.625 5.4 5 4 abnormal amnion morphology 0.23270724598062 0.451559484641431 0.619424228195798 0.625 5.4 5 4 abnormal level of surface class II molecules 0.23270724598062 0.451559484641431 0.619424228195798 0.625 5.4 5 4 sepsis 0.23270724598062 0.451559484641431 0.619424228195798 0.625 5.4 5 4 abnormal Langerhans cell physiology 0.23270724598062 0.451559484641431 0.619424228195798 0.625 5.4 5 4 decreased adipocyte glucose uptake 0.23270724598062 0.451559484641431 0.619424228195798 0.625 5.4 5 4 absent pre-B cells 0.368177103995528 0.594122962172478 0.619424228195798 0.625 5.4 5 4 failure of vascular branching 0.368177103995528 0.594122962172478 0.619424228195798 0.625 5.4 5 4 enlarged pituitary gland 0.368177103995528 0.594122962172478 0.619424228195798 0.625 5.4 5 4 absent skin pigmentation 0.368177103995528 0.594122962172478 0.619424228195798 0.625 5.4 5 4 unidirectional circling 0.368177103995528 0.594122962172478 0.619424228195798 0.625 5.4 5 4 abnormal circulating calcium level 0.368177103995528 0.594122962172478 0.619424228195798 0.625 5.4 5 4 abnormal parturition 0.368177103995528 0.594122962172478 0.619424228195798 0.625 5.4 5 4 abnormal muscle precursor cell migration 0.368177103995528 0.594122962172478 0.619424228195798 0.625 5.4 5 4 abnormal soft palate morphology 0.368177103995528 0.594122962172478 0.619424228195798 0.625 5.4 5 4 calcified muscle 0.368177103995528 0.594122962172478 0.619424228195798 0.625 5.4 5 4 loss of GABAergic neurons 0.368177103995528 0.594122962172478 0.619424228195798 0.625 5.4 5 4 urinary incontinence 0.368177103995528 0.594122962172478 0.619424228195798 0.625 5.4 5 4 decreased circulating renin level 0.368177103995528 0.594122962172478 0.619424228195798 0.625 5.4 5 4 abnormal platelet shape 0.368177103995528 0.594122962172478 0.619424228195798 0.625 5.4 5 4 hair follicle degeneration 0.368177103995528 0.594122962172478 0.619424228195798 0.625 5.4 5 4 abnormal thermosensation 0.368177103995528 0.594122962172478 0.619424228195798 0.625 5.4 5 4 lymph node inflammation 0.368177103995528 0.594122962172478 0.619424228195798 0.625 5.4 5 4 abnormal gastric gland morphology 0.368177103995528 0.594122962172478 0.619424228195798 0.625 5.4 5 4 abnormal miscarriage rate 0.368177103995528 0.594122962172478 0.619424228195798 0.625 5.4 5 4 bowed fibula 0.368177103995528 0.594122962172478 0.619424228195798 0.625 5.4 5 4 increased epididymis weight 0.368177103995528 0.594122962172478 0.619424228195798 0.625 5.4 5 4 abnormal optic choroid morphology 0.368177103995528 0.594122962172478 0.619424228195798 0.625 5.4 5 4 increased circulating prolactin level 0.368177103995528 0.594122962172478 0.619424228195798 0.625 5.4 5 4 abnormal canal of Schlemm morphology 0.368177103995528 0.594122962172478 0.619424228195798 0.625 5.4 5 4 abnormal circulating corticosterone level 0.368177103995528 0.594122962172478 0.619424228195798 0.625 5.4 5 4 impaired behavioral response to alcohol 0.368177103995528 0.594122962172478 0.619424228195798 0.625 5.4 5 4 abnormal frontonasal prominence morphology 0.368177103995528 0.594122962172478 0.619424228195798 0.625 5.4 5 4 abnormal sensory neuron physiology 0.368177103995528 0.594122962172478 0.619424228195798 0.625 5.4 5 4 abnormal hepatic vein morphology 0.368177103995528 0.594122962172478 0.619424228195798 0.625 5.4 5 4 pulmonary artery hypoplasia 0.368177103995528 0.594122962172478 0.619424228195798 0.625 5.4 5 4 myocardial trabeculae hypoplasia 0.368177103995528 0.594122962172478 0.619424228195798 0.625 5.4 5 4 abnormal pulmonary acinus morphology 0.368177103995528 0.594122962172478 0.619424228195798 0.625 5.4 5 4 abnormal bronchus epithelium morphology 0.368177103995528 0.594122962172478 0.619424228195798 0.625 5.4 5 4 lethality during fetal growth through weaning, incomplete penetrance 0.368177103995528 0.594122962172478 0.619424228195798 0.625 5.4 5 4 absent Reichert's membrane 0.368177103995528 0.594122962172478 0.619424228195798 0.625 5.4 5 4 increased cardiac stroke volume 0.368177103995528 0.594122962172478 0.619424228195798 0.625 5.4 5 4 increased circulating lactate level 0.368177103995528 0.594122962172478 0.619424228195798 0.625 5.4 5 4 decreased vascular endothelial cell proliferation 0.368177103995528 0.594122962172478 0.619424228195798 0.625 5.4 5 4 polyuria 0.0216113820048792 0.0869757711906254 0.617815334096588 0.623376623376623 5.4 5 4 abnormal epidermal layer morphology 0.0288936035696893 0.112301310749379 0.617628795650302 0.623188405797101 5.4 5 4 altered response to myocardial infarction 0.0714676633031819 0.206956708343033 0.616671231626038 0.622222222222222 5.4 5 4 increased brown adipose tissue amount 0.0984100783737727 0.267243526151484 0.616075989124469 0.621621621621622 5.4 5 4 decreased granulocyte number 0.137629603997728 0.316262023043277 0.615152336966861 0.620689655172414 5.4 5 4 abnormal CD8-positive, alpha-beta T cell physiology 0.137629603997728 0.316262023043277 0.615152336966861 0.620689655172414 5.4 5 4 enlarged epididymis 0.137629603997728 0.316262023043277 0.615152336966861 0.620689655172414 5.4 5 4 polychromatophilia 0.137629603997728 0.316262023043277 0.615152336966861 0.620689655172414 5.4 5 4 abnormal digestive system physiology 0.0631649440534691 0.186639416788461 0.614468834370231 0.62 5.4 5 4 increased food intake 0.0206022677112772 0.0832626172734397 0.613524949832028 0.619047619047619 5.4 5 4 abnormal spleen white pulp morphology 0.0864415674685061 0.244037244026509 0.613524949832028 0.619047619047619 5.4 5 4 increased keratinocyte proliferation 0.197283582829471 0.408737821986975 0.613524949832028 0.619047619047619 5.4 5 4 decreased IgM level 0.013881124515279 0.0636178425410006 0.613038411410274 0.618556701030928 5.4 5 4 abnormal T-helper 2 physiology 0.0559053621325266 0.182501717620361 0.612666872979116 0.618181818181818 5.4 5 4 decreased osteoblast cell number 0.119784747318614 0.294493642506925 0.612136884334671 0.617647058823529 5.4 5 4 small seminal vesicle 0.169114339949303 0.375432325411772 0.609894624685093 0.615384615384615 5.4 5 4 abnormal digestion 0.296147425614153 0.518231953018083 0.609894624685093 0.615384615384615 5.4 5 4 abnormal intercostal muscle morphology 0.296147425614153 0.518231953018083 0.609894624685093 0.615384615384615 5.4 5 4 abnormal otolith morphology 0.296147425614153 0.518231953018083 0.609894624685093 0.615384615384615 5.4 5 4 small otic vesicle 0.296147425614153 0.518231953018083 0.609894624685093 0.615384615384615 5.4 5 4 small pituitary gland 0.296147425614153 0.518231953018083 0.609894624685093 0.615384615384615 5.4 5 4 increased renin activity 0.296147425614153 0.518231953018083 0.609894624685093 0.615384615384615 5.4 5 4 orthokeratosis 0.296147425614153 0.518231953018083 0.609894624685093 0.615384615384615 5.4 5 4 increased macrophage cell number 0.0593259352865247 0.186639416788461 0.608557136473064 0.614035087719298 5.4 5 4 abnormal body temperature homeostasis 0.146079525879466 0.330164295141423 0.607435372166202 0.612903225806452 5.4 5 4 abnormal CD8-positive, alpha beta T cell morphology 0.146079525879466 0.330164295141423 0.607435372166202 0.612903225806452 5.4 5 4 abnormal T cell proliferation 0.146079525879466 0.330164295141423 0.607435372166202 0.612903225806452 5.4 5 4 abnormal epidermis stratum corneum morphology 0.080655299831476 0.228899096783567 0.606782917416292 0.612244897959184 5.4 5 4 abnormal systemic arterial blood pressure 0.126897145913279 0.294868426398207 0.605659245347002 0.611111111111111 5.4 5 4 abnormal white adipose tissue morphology 0.246306247524699 0.451559484641431 0.605659245347002 0.611111111111111 5.4 5 4 abnormal sperm axoneme morphology 0.246306247524699 0.451559484641431 0.605659245347002 0.611111111111111 5.4 5 4 abnormal macrophage chemotaxis 0.246306247524699 0.451559484641431 0.605659245347002 0.611111111111111 5.4 5 4 impaired leukocyte tethering or rolling 0.246306247524699 0.451559484641431 0.605659245347002 0.611111111111111 5.4 5 4 abnormal B cell morphology 0.208522019754503 0.429741942120403 0.603265335286342 0.608695652173913 5.4 5 4 abnormal lens development 0.208522019754503 0.429741942120403 0.603265335286342 0.608695652173913 5.4 5 4 abnormal circulating cholesterol level 0.178525840632501 0.388694116913213 0.601726393104489 0.607142857142857 5.4 5 4 increased circulating luteinizing hormone level 0.178525840632501 0.388694116913213 0.601726393104489 0.607142857142857 5.4 5 4 absent vibrissae 0.154044677256453 0.343818873643271 0.600653797038349 0.606060606060606 5.4 5 4 diarrhea 0.154044677256453 0.343818873643271 0.600653797038349 0.606060606060606 5.4 5 4 abnormal CD4-positive, alpha-beta T cell physiology 0.0516685456875038 0.171940478123967 0.600230801406632 0.605633802816901 5.4 5 4 abnormal eye electrophysiology 0.0160916904044681 0.0695152957111566 0.597923552506357 0.603305785123967 5.4 5 4 lung inflammation 0.0114869367357947 0.05442620024817 0.597562196612416 0.602941176470588 5.4 5 4 increased neutrophil cell number 0.0112380443852953 0.0532976842867914 0.594647259067966 0.6 5.4 5 4 abnormal hair cycle 0.187260204551039 0.396446877399224 0.594647259067966 0.6 5.4 5 4 increased urine glucose level 0.25816203811925 0.456836565781549 0.594647259067966 0.6 5.4 5 4 brain inflammation 0.25816203811925 0.456836565781549 0.594647259067966 0.6 5.4 5 4 abnormal fibula morphology 0.25816203811925 0.456836565781549 0.594647259067966 0.6 5.4 5 4 abnormal trachea morphology 0.25816203811925 0.456836565781549 0.594647259067966 0.6 5.4 5 4 abnormal thymocyte activation 0.25816203811925 0.456836565781549 0.594647259067966 0.6 5.4 5 4 interdigital webbing 0.309766490067497 0.527488618057695 0.594647259067966 0.6 5.4 5 4 decreased salivation 0.309766490067497 0.527488618057695 0.594647259067966 0.6 5.4 5 4 abnormal enteric neuron morphology 0.309766490067497 0.527488618057695 0.594647259067966 0.6 5.4 5 4 increased airway responsiveness 0.309766490067497 0.527488618057695 0.594647259067966 0.6 5.4 5 4 abnormal zygomatic bone morphology 0.309766490067497 0.527488618057695 0.594647259067966 0.6 5.4 5 4 abnormal neurotransmitter secretion 0.309766490067497 0.527488618057695 0.594647259067966 0.6 5.4 5 4 lactation failure 0.309766490067497 0.527488618057695 0.594647259067966 0.6 5.4 5 4 herniated liver 0.309766490067497 0.527488618057695 0.594647259067966 0.6 5.4 5 4 kidney hemorrhage 0.382461086567532 0.613392619494994 0.594647259067966 0.6 5.4 5 4 abnormal airway responsiveness 0.382461086567532 0.613392619494994 0.594647259067966 0.6 5.4 5 4 abnormal scala media morphology 0.382461086567532 0.613392619494994 0.594647259067966 0.6 5.4 5 4 aneurysm 0.382461086567532 0.613392619494994 0.594647259067966 0.6 5.4 5 4 intestinal hypoperistalsis 0.382461086567532 0.613392619494994 0.594647259067966 0.6 5.4 5 4 abnormal hypaxial muscle morphology 0.382461086567532 0.613392619494994 0.594647259067966 0.6 5.4 5 4 abnormal ear physiology 0.382461086567532 0.613392619494994 0.594647259067966 0.6 5.4 5 4 abnormal reproductive system development 0.382461086567532 0.613392619494994 0.594647259067966 0.6 5.4 5 4 decreased cochlear inner hair cell number 0.382461086567532 0.613392619494994 0.594647259067966 0.6 5.4 5 4 decreased prolactin level 0.382461086567532 0.613392619494994 0.594647259067966 0.6 5.4 5 4 absent coat pigmentation 0.382461086567532 0.613392619494994 0.594647259067966 0.6 5.4 5 4 increased susceptibility to atherosclerosis 0.382461086567532 0.613392619494994 0.594647259067966 0.6 5.4 5 4 absent axillary lymph nodes 0.382461086567532 0.613392619494994 0.594647259067966 0.6 5.4 5 4 crystalluria 0.382461086567532 0.613392619494994 0.594647259067966 0.6 5.4 5 4 abnormal retinal blood vessel pattern 0.382461086567532 0.613392619494994 0.594647259067966 0.6 5.4 5 4 abnormal heart and great artery attachment 0.382461086567532 0.613392619494994 0.594647259067966 0.6 5.4 5 4 decreased susceptibility to induced arthritis 0.0979764882265901 0.266490233859034 0.591169789716691 0.596491228070175 5.4 5 4 abnormal cytotoxic T cell physiology 0.146415963168191 0.330164295141423 0.58992783637695 0.595238095238095 5.4 5 4 increased white adipose tissue amount 0.168678178304554 0.374631221904087 0.58929007655384 0.594594594594595 5.4 5 4 abnormal urine homeostasis 0.0448859949746008 0.152220739603708 0.588453016786008 0.59375 5.4 5 4 abnormal spongiotrophoblast layer morphology 0.195392521484856 0.406897360563902 0.588453016786008 0.59375 5.4 5 4 decreased urine osmolality 0.132905796801901 0.30839847905292 0.586556820169082 0.591836734693878 5.4 5 4 decreased macrophage cell number 0.152374664288949 0.340396926285372 0.58563745211239 0.590909090909091 5.4 5 4 increased activated T cell number 0.268620593893846 0.474400942357786 0.58563745211239 0.590909090909091 5.4 5 4 abnormal female reproductive system physiology 0.268620593893846 0.474400942357786 0.58563745211239 0.590909090909091 5.4 5 4 decreased susceptibility to viral infection induced morbidity/mortality 0.268620593893846 0.474400942357786 0.58563745211239 0.590909090909091 5.4 5 4 abnormal humoral immune response 0.0430542864500146 0.146108509610384 0.585208413685935 0.59047619047619 5.4 5 4 small lens 0.175416616031593 0.382525695192077 0.584482348656547 0.58974358974359 5.4 5 4 enlarged sebaceous gland 0.32116454169207 0.53581274142121 0.582987508890162 0.588235294117647 5.4 5 4 abnormal cranial suture morphology 0.32116454169207 0.53581274142121 0.582987508890162 0.588235294117647 5.4 5 4 abnormal testis development 0.32116454169207 0.53581274142121 0.582987508890162 0.588235294117647 5.4 5 4 stomach inflammation 0.236462175865097 0.451559484641431 0.580977207135369 0.586206896551724 5.4 5 4 increased susceptibility to induced arthritis 0.236462175865097 0.451559484641431 0.580977207135369 0.586206896551724 5.4 5 4 increased double-positive T cell number 0.236462175865097 0.451559484641431 0.580977207135369 0.586206896551724 5.4 5 4 abnormal inflammatory response 0.103720933076453 0.281512079681045 0.578129279649411 0.583333333333333 5.4 5 4 abnormal esophagus morphology 0.393265927388282 0.621655145404713 0.578129279649411 0.583333333333333 5.4 5 4 abnormal enteric nervous system morphology 0.393265927388282 0.621655145404713 0.578129279649411 0.583333333333333 5.4 5 4 abnormal gastrocnemius morphology 0.393265927388282 0.621655145404713 0.578129279649411 0.583333333333333 5.4 5 4 decreased circulating ketone body level 0.393265927388282 0.621655145404713 0.578129279649411 0.583333333333333 5.4 5 4 delayed somite formation 0.393265927388282 0.621655145404713 0.578129279649411 0.583333333333333 5.4 5 4 absent cochlear hair cells 0.393265927388282 0.621655145404713 0.578129279649411 0.583333333333333 5.4 5 4 abnormal B cell proliferation 0.393265927388282 0.621655145404713 0.578129279649411 0.583333333333333 5.4 5 4 abnormal anogenital distance 0.393265927388282 0.621655145404713 0.578129279649411 0.583333333333333 5.4 5 4 abnormal aorta elastic tissue morphology 0.393265927388282 0.621655145404713 0.578129279649411 0.583333333333333 5.4 5 4 increased skeletal muscle glycogen level 0.393265927388282 0.621655145404713 0.578129279649411 0.583333333333333 5.4 5 4 abnormal cranial ganglia morphology 0.244279605788602 0.451559484641431 0.575465089420612 0.580645161290323 5.4 5 4 enlarged adrenal glands 0.330894397835396 0.550752636075977 0.573782442960318 0.578947368421053 5.4 5 4 flaky skin 0.330894397835396 0.550752636075977 0.573782442960318 0.578947368421053 5.4 5 4 altered susceptibility to infection 0.330894397835396 0.550752636075977 0.573782442960318 0.578947368421053 5.4 5 4 abnormal photoreceptor inner segment morphology 0.330894397835396 0.550752636075977 0.573782442960318 0.578947368421053 5.4 5 4 eyelids fail to open 0.330894397835396 0.550752636075977 0.573782442960318 0.578947368421053 5.4 5 4 decreased susceptibility to weight gain 0.330894397835396 0.550752636075977 0.573782442960318 0.578947368421053 5.4 5 4 abnormal leukocyte cell number 0.286313304976917 0.502436928486829 0.571776210642275 0.576923076923077 5.4 5 4 decreased Peyer's patch number 0.286313304976917 0.502436928486829 0.571776210642275 0.576923076923077 5.4 5 4 abnormal skin pigmentation 0.223069586267339 0.451559484641431 0.569870289940134 0.575 5.4 5 4 decreased circulating progesterone level 0.293894776071584 0.515559418531781 0.566330722921872 0.571428571428571 5.4 5 4 increased vasoconstriction 0.339333311838957 0.564609774715321 0.566330722921872 0.571428571428571 5.4 5 4 abnormal antigen presentation 0.401827625983244 0.621655145404713 0.566330722921872 0.571428571428571 5.4 5 4 abnormal olfactory system physiology 0.401827625983244 0.621655145404713 0.566330722921872 0.571428571428571 5.4 5 4 abnormal prepulse inhibition 0.401827625983244 0.621655145404713 0.566330722921872 0.571428571428571 5.4 5 4 abnormal decidualization 0.401827625983244 0.621655145404713 0.566330722921872 0.571428571428571 5.4 5 4 abnormal positive T cell selection 0.401827625983244 0.621655145404713 0.566330722921872 0.571428571428571 5.4 5 4 increased insulin secretion 0.264467861072185 0.467564892975877 0.562504163983211 0.567567567567568 5.4 5 4 arrested T cell differentiation 0.300803215275789 0.526009137433057 0.561611300230856 0.566666666666667 5.4 5 4 salivary gland inflammation 0.300803215275789 0.526009137433057 0.561611300230856 0.566666666666667 5.4 5 4 delayed wound healing 0.239933474488275 0.451559484641431 0.560174954194461 0.565217391304348 5.4 5 4 abnormal circulating insulin level 0.346748740274992 0.568483774501328 0.560174954194461 0.565217391304348 5.4 5 4 pancreas inflammation 0.346748740274992 0.568483774501328 0.560174954194461 0.565217391304348 5.4 5 4 abnormal crista ampullaris morphology 0.346748740274992 0.568483774501328 0.560174954194461 0.565217391304348 5.4 5 4 increased dopamine level 0.307134428464847 0.527488618057695 0.557481805376218 0.5625 5.4 5 4 abnormal extraembryonic endoderm formation 0.40884266103634 0.621655145404713 0.557481805376218 0.5625 5.4 5 4 abnormal molar crown morphology 0.40884266103634 0.621655145404713 0.557481805376218 0.5625 5.4 5 4 abnormal wound healing 0.40884266103634 0.621655145404713 0.557481805376218 0.5625 5.4 5 4 decreased circulating growth hormone level 0.40884266103634 0.621655145404713 0.557481805376218 0.5625 5.4 5 4 abnormal fertilization 0.40884266103634 0.621655145404713 0.557481805376218 0.5625 5.4 5 4 abnormal urinary bladder physiology 0.40884266103634 0.621655145404713 0.557481805376218 0.5625 5.4 5 4 abnormal skin physiology 0.312966143198787 0.527488618057695 0.553838133445654 0.558823529411765 5.4 5 4 abnormal NK cell physiology 0.231681640889723 0.451559484641431 0.552404557604121 0.557377049180328 5.4 5 4 increased susceptibility to bacterial infection induced morbidity/mortality 0.215537670636914 0.444016526467349 0.55059931395182 0.555555555555556 5.4 5 4 distorted hair follicle pattern 0.505513745411169 0.621655145404713 0.55059931395182 0.555555555555556 5.4 5 4 absent parathyroid glands 0.505513745411169 0.621655145404713 0.55059931395182 0.555555555555556 5.4 5 4 abnormal retinal rod cell morphology 0.414737409401285 0.621655145404713 0.55059931395182 0.555555555555556 5.4 5 4 absent enteric neurons 0.505513745411169 0.621655145404713 0.55059931395182 0.555555555555556 5.4 5 4 abnormal geniculate ganglion morphology 0.505513745411169 0.621655145404713 0.55059931395182 0.555555555555556 5.4 5 4 small nodose ganglion 0.505513745411169 0.621655145404713 0.55059931395182 0.555555555555556 5.4 5 4 psoriasis 0.505513745411169 0.621655145404713 0.55059931395182 0.555555555555556 5.4 5 4 thick dermal layer 0.414737409401285 0.621655145404713 0.55059931395182 0.555555555555556 5.4 5 4 wavy vibrissae 0.505513745411169 0.621655145404713 0.55059931395182 0.555555555555556 5.4 5 4 multifocal hepatic necrosis 0.505513745411169 0.621655145404713 0.55059931395182 0.555555555555556 5.4 5 4 abnormal laryngeal cartilage morphology 0.505513745411169 0.621655145404713 0.55059931395182 0.555555555555556 5.4 5 4 abnormal gut-associated lymphoid tissue morphology 0.505513745411169 0.621655145404713 0.55059931395182 0.555555555555556 5.4 5 4 yellow coat color 0.505513745411169 0.621655145404713 0.55059931395182 0.555555555555556 5.4 5 4 decreased susceptibility to induced choroidal neovascularization 0.505513745411169 0.621655145404713 0.55059931395182 0.555555555555556 5.4 5 4 abnormal stria vascularis vasculature morphology 0.505513745411169 0.621655145404713 0.55059931395182 0.555555555555556 5.4 5 4 short frontal bone 0.505513745411169 0.621655145404713 0.55059931395182 0.555555555555556 5.4 5 4 decreased thyroid-stimulating hormone level 0.505513745411169 0.621655145404713 0.55059931395182 0.555555555555556 5.4 5 4 increased stomach mucosa thickness 0.505513745411169 0.621655145404713 0.55059931395182 0.555555555555556 5.4 5 4 abnormal glycogen homeostasis 0.414737409401285 0.621655145404713 0.55059931395182 0.555555555555556 5.4 5 4 decreased pulmonary ventilation 0.505513745411169 0.621655145404713 0.55059931395182 0.555555555555556 5.4 5 4 absent cervical lymph nodes 0.505513745411169 0.621655145404713 0.55059931395182 0.555555555555556 5.4 5 4 abnormal ventricle myocardium morphology 0.505513745411169 0.621655145404713 0.55059931395182 0.555555555555556 5.4 5 4 decreased susceptibility to parasitic infection induced morbidity/mortality 0.505513745411169 0.621655145404713 0.55059931395182 0.555555555555556 5.4 5 4 decreased fatty acid oxidation 0.505513745411169 0.621655145404713 0.55059931395182 0.555555555555556 5.4 5 4 decreased threshold for auditory brainstem response 0.323375425684137 0.539320396506397 0.547701422825758 0.552631578947368 5.4 5 4 waved hair 0.41978950415513 0.621655145404713 0.545093320812302 0.55 5.4 5 4 abnormal Peyer's patch T cell area morphology 0.41978950415513 0.621655145404713 0.545093320812302 0.55 5.4 5 4 abnormal lens epithelium morphology 0.41978950415513 0.621655145404713 0.545093320812302 0.55 5.4 5 4 increased eosinophil cell number 0.274379938666843 0.484400353040292 0.543494806675022 0.548387096774194 5.4 5 4 abnormal T cell subpopulation ratio 0.373886799097435 0.602945486388894 0.540588417334514 0.545454545454545 5.4 5 4 abnormal cytokine secretion 0.160056908014476 0.355642303426539 0.540588417334514 0.545454545454545 5.4 5 4 absent semicircular canals 0.506065258183011 0.621655145404713 0.540588417334514 0.545454545454545 5.4 5 4 increased mast cell number 0.506065258183011 0.621655145404713 0.540588417334514 0.545454545454545 5.4 5 4 abnormal large intestine morphology 0.506065258183011 0.621655145404713 0.540588417334514 0.545454545454545 5.4 5 4 abnormal lymph circulation 0.506065258183011 0.621655145404713 0.540588417334514 0.545454545454545 5.4 5 4 abnormal hair medulla 0.506065258183011 0.621655145404713 0.540588417334514 0.545454545454545 5.4 5 4 abnormal circulating lipid level 0.42418857337309 0.621655145404713 0.540588417334514 0.545454545454545 5.4 5 4 decreased palatine bone horizontal plate size 0.506065258183011 0.621655145404713 0.540588417334514 0.545454545454545 5.4 5 4 rough coat 0.42418857337309 0.621655145404713 0.540588417334514 0.545454545454545 5.4 5 4 shortened PR interval 0.506065258183011 0.621655145404713 0.540588417334514 0.545454545454545 5.4 5 4 increased subcutaneous adipose tissue amount 0.506065258183011 0.621655145404713 0.540588417334514 0.545454545454545 5.4 5 4 chylous ascites 0.506065258183011 0.621655145404713 0.540588417334514 0.545454545454545 5.4 5 4 hypolactation 0.506065258183011 0.621655145404713 0.540588417334514 0.545454545454545 5.4 5 4 abnormal immune system morphology 0.340391720362068 0.566181480709224 0.53862976364852 0.543478260869565 5.4 5 4 abnormal hair shaft morphology 0.344036424859897 0.568483774501328 0.536834331103025 0.541666666666667 5.4 5 4 small lymph nodes 0.428069172661134 0.621655145404713 0.536834331103025 0.541666666666667 5.4 5 4 abnormal immune system physiology 0.22379163181633 0.451559484641431 0.535502235988625 0.540322580645161 5.4 5 4 abnormal mast cell morphology 0.506570846124765 0.621655145404713 0.533657796599456 0.538461538461538 5.4 5 4 short hair 0.506570846124765 0.621655145404713 0.533657796599456 0.538461538461538 5.4 5 4 abnormal renal/urinary system morphology 0.506570846124765 0.621655145404713 0.533657796599456 0.538461538461538 5.4 5 4 increased circulating adrenocorticotropin level 0.506570846124765 0.621655145404713 0.533657796599456 0.538461538461538 5.4 5 4 abnormal ocular fundus morphology 0.431529803364561 0.621655145404713 0.533657796599456 0.538461538461538 5.4 5 4 abnormal tectorial membrane morphology 0.431529803364561 0.621655145404713 0.533657796599456 0.538461538461538 5.4 5 4 abnormal dopaminergic neuron morphology 0.506570846124765 0.621655145404713 0.533657796599456 0.538461538461538 5.4 5 4 abnormal insulin secretion 0.506570846124765 0.621655145404713 0.533657796599456 0.538461538461538 5.4 5 4 decreased luteinizing hormone level 0.506570846124765 0.621655145404713 0.533657796599456 0.538461538461538 5.4 5 4 decreased hepatocyte number 0.507040352744096 0.621771199137757 0.528575341393747 0.533333333333333 5.4 5 4 placental labyrinth hypoplasia 0.507040352744096 0.621771199137757 0.528575341393747 0.533333333333333 5.4 5 4 joint inflammation 0.507040352744096 0.621771199137757 0.528575341393747 0.533333333333333 5.4 5 4 decreased susceptibility to injury 0.371962823548153 0.600037304524015 0.524688758001146 0.529411764705882 5.4 5 4 decreased cytotoxic T cell cytolysis 0.442422536983413 0.621655145404713 0.524688758001146 0.529411764705882 5.4 5 4 nephrocalcinosis 0.507480545298644 0.622157642400383 0.524688758001146 0.529411764705882 5.4 5 4 abnormal T cell activation 0.378256734575858 0.609794962577736 0.522325295127267 0.527027027027027 5.4 5 4 increased acute inflammation 0.50829131570292 0.622844654094096 0.519136496011716 0.523809523809524 5.4 5 4 increased bone ossification 0.50829131570292 0.622844654094096 0.519136496011716 0.523809523809524 5.4 5 4 abnormal retinal cone cell morphology 0.508668391298287 0.622999814551694 0.517084573102579 0.521739130434783 5.4 5 4 increased susceptibility to age related obesity 0.508668391298287 0.622999814551694 0.517084573102579 0.521739130434783 5.4 5 4 cryptorchism 0.509377293148627 0.623714504901407 0.513892693021699 0.518518518518518 5.4 5 4 abnormal circulating glucose level 0.509712417913091 0.62397127931044 0.512626947472384 0.517241379310345 5.4 5 4 autoimmune response 0.510036394010958 0.624060762470369 0.511524523929433 0.516129032258065 5.4 5 4 decreased susceptibility to bacterial infection induced morbidity/mortality 0.510036394010958 0.624060762470369 0.511524523929433 0.516129032258065 5.4 5 4 impaired natural killer cell mediated cytotoxicity 0.513563319299365 0.628221665481766 0.504233055934825 0.508771929824561 5.4 5 4 abnormal stria vascularis morphology 0.584110115624313 0.713641410911335 0.495539382556638 0.5 5.4 5 4 abnormal spleen germinal center morphology 0.584110115624313 0.713641410911335 0.495539382556638 0.5 5.4 5 4 increased pulmonary respiratory rate 0.611314066266287 0.744865902443002 0.495539382556638 0.5 5.4 5 4 abnormal estrous cycle 0.581954824893942 0.711357556227853 0.495539382556638 0.5 5.4 5 4 intestinal ulcer 0.59239405803275 0.72358468910212 0.495539382556638 0.5 5.4 5 4 decreased skin tensile strength 0.596003118127192 0.727635708633812 0.495539382556638 0.5 5.4 5 4 absent placental labyrinth 0.596003118127192 0.727635708633812 0.495539382556638 0.5 5.4 5 4 increased urine phosphate level 0.618864588977739 0.75369677605 0.495539382556638 0.5 5.4 5 4 impaired behavioral response to cocaine 0.618864588977739 0.75369677605 0.495539382556638 0.5 5.4 5 4 small petrosal ganglion 0.628566404254806 0.763642945340088 0.495539382556638 0.5 5.4 5 4 abnormal pituitary secretion 0.628566404254806 0.763642945340088 0.495539382556638 0.5 5.4 5 4 abnormal gland morphology 0.628566404254806 0.763642945340088 0.495539382556638 0.5 5.4 5 4 decreased circulating parathyroid hormone level 0.628566404254806 0.763642945340088 0.495539382556638 0.5 5.4 5 4 delayed dark adaptation 0.628566404254806 0.763642945340088 0.495539382556638 0.5 5.4 5 4 intestinal edema 0.628566404254806 0.763642945340088 0.495539382556638 0.5 5.4 5 4 lymphedema 0.628566404254806 0.763642945340088 0.495539382556638 0.5 5.4 5 4 absent CD4-positive, alpha beta T cells 0.628566404254806 0.763642945340088 0.495539382556638 0.5 5.4 5 4 increased defecation amount 0.628566404254806 0.763642945340088 0.495539382556638 0.5 5.4 5 4 abnormal placental transport 0.628566404254806 0.763642945340088 0.495539382556638 0.5 5.4 5 4 increased susceptibility to viral infection induced morbidity/mortality 0.578277997665683 0.707210678069511 0.495539382556638 0.5 5.4 5 4 abnormal crypts of Lieberkuhn morphology 0.580021883117396 0.709169050997554 0.495539382556638 0.5 5.4 5 4 abnormal iron level 0.600223681196002 0.732428946271795 0.495539382556638 0.5 5.4 5 4 decreased heart rate variability 0.600223681196002 0.732428946271795 0.495539382556638 0.5 5.4 5 4 abnormal pituitary gland morphology 0.605238044451853 0.737643133549232 0.495539382556638 0.5 5.4 5 4 abnormal intestinal absorption 0.605238044451853 0.737643133549232 0.495539382556638 0.5 5.4 5 4 increased circulating estradiol level 0.605238044451853 0.737643133549232 0.495539382556638 0.5 5.4 5 4 abnormal pancreatic alpha cell morphology 0.605238044451853 0.737643133549232 0.495539382556638 0.5 5.4 5 4 abnormal intestinal lipid absorption 0.605238044451853 0.737643133549232 0.495539382556638 0.5 5.4 5 4 increased susceptibility to parasitic infection 0.640224462060783 0.776284973549279 0.484527396277602 0.488888888888889 5.4 5 4 abnormal intestinal mucosa morphology 0.630886533051123 0.766274536603842 0.484015210869274 0.488372093023256 5.4 5 4 abnormal regulatory T cell physiology 0.669142585872675 0.802358246497122 0.473994192010697 0.478260869565217 5.4 5 4 abnormal bile salt homeostasis 0.675741120331076 0.810075198469182 0.47194226910156 0.476190476190476 5.4 5 4 abnormal nail morphology 0.683318314245359 0.811390149635994 0.469458362422078 0.473684210526316 5.4 5 4 abnormal respiratory system morphology 0.702553565598204 0.82472958679827 0.462503423719529 0.466666666666667 5.4 5 4 greasy coat 0.702553565598204 0.82472958679827 0.462503423719529 0.466666666666667 5.4 5 4 absent lateral semicircular canal 0.715116368566002 0.836292110748798 0.45742096851382 0.461538461538462 5.4 5 4 decreased alcohol consumption 0.715116368566002 0.836292110748798 0.45742096851382 0.461538461538462 5.4 5 4 abnormal vestibulocochlear ganglion morphology 0.715116368566002 0.836292110748798 0.45742096851382 0.461538461538462 5.4 5 4 decreased follicle stimulating hormone level 0.715116368566002 0.836292110748798 0.45742096851382 0.461538461538462 5.4 5 4 abnormal gut flora balance 0.715116368566002 0.836292110748798 0.45742096851382 0.461538461538462 5.4 5 4 abnormal lens fiber morphology 0.747990257190526 0.836292110748798 0.45742096851382 0.461538461538462 5.4 5 4 abnormal enteric ganglia morphology 0.730650692647969 0.836292110748798 0.450490347778762 0.454545454545455 5.4 5 4 abnormal nerve fiber response 0.730650692647969 0.836292110748798 0.450490347778762 0.454545454545455 5.4 5 4 enlarged placenta 0.730650692647969 0.836292110748798 0.450490347778762 0.454545454545455 5.4 5 4 nuclear cataracts 0.754758020160223 0.838901061281749 0.445985444300974 0.45 5.4 5 4 abnormal feces composition 0.79439723645957 0.879422841875024 0.436074656649842 0.44 5.4 5 4 mixed cellular infiltration to dermis 0.7782434153787 0.862115562571595 0.433596959737058 0.4375 5.4 5 4 increased pancreatic beta cell number 0.7782434153787 0.862115562571595 0.433596959737058 0.4375 5.4 5 4 abnormal fluid regulation 0.792968095290789 0.878036117086952 0.424748042191404 0.428571428571429 5.4 5 4 abnormal spleen periarteriolar lymphoid sheath morphology 0.792968095290789 0.878036117086952 0.424748042191404 0.428571428571429 5.4 5 4 hypoalgesia 0.814020695032083 0.896584573608091 0.424748042191404 0.428571428571429 5.4 5 4 dry skin 0.814020695032083 0.896584573608091 0.424748042191404 0.428571428571429 5.4 5 4 decreased liver glycogen level 0.825547511488075 0.907646159039376 0.417296322152958 0.421052631578947 5.4 5 4 decreased oligodendrocyte number 0.810497909555276 0.896584573608091 0.412949485463865 0.416666666666667 5.4 5 4 decreased susceptibility to parasitic infection 0.897081091251241 0.964551205743446 0.402625748327268 0.40625 5.4 5 4 increased urine calcium level 0.872740505706643 0.945480484855478 0.39643150604531 0.4 5.4 5 4 abnormal circulating cytokine level 0.872740505706643 0.945480484855478 0.39643150604531 0.4 5.4 5 4 abnormal membranous labyrinth morphology 0.870111372673571 0.945480484855478 0.381184140428183 0.384615384615385 5.4 5 4 total cataracts 0.870111372673571 0.945480484855478 0.381184140428183 0.384615384615385 5.4 5 4 abnormal hair cuticle 0.91296874899734 0.980574163700726 0.35395670182617 0.357142857142857 5.4 5 4 increased B-1 B cell number 0.91296874899734 0.980574163700726 0.35395670182617 0.357142857142857 5.4 5 4 abnormal renal reabsorbtion 0.91296874899734 0.980574163700726 0.35395670182617 0.357142857142857 5.4 5 4 decreased airway responsiveness 0.992032942615897 1 0.270294208667257 0.272727272727273 5.4 5 4 dystonia 3.49700316514934e-06 7.0721913604138e-05 1.19232260566111 1 5.2 5 2 impaired behavioral response to addictive substance 3.49700316514934e-06 7.0721913604138e-05 1.19232260566111 1 5.2 5 2 axonal dystrophy 3.69020869159139e-05 0.000544771164411488 1.19232260566111 1 5.2 5 2 abnormal corticospinal tract morphology 8.09354269494547e-05 0.00105131527173247 1.19232260566111 1 5.2 5 2 abnormal AMPA-mediated synaptic currents 8.09354269494547e-05 0.00105131527173247 1.19232260566111 1 5.2 5 2 embryonic lethality between implantation and placentation, incomplete penetrance 8.09354269494547e-05 0.00105131527173247 1.19232260566111 1 5.2 5 2 abnormal proximal-distal axis patterning 0.000177505214650253 0.0019744035002372 1.19232260566111 1 5.2 5 2 abnormal spinal cord ventral horn morphology 0.000177505214650253 0.0019744035002372 1.19232260566111 1 5.2 5 2 absent seminal vesicle 0.000389285556754312 0.00382746174872075 1.19232260566111 1 5.2 5 2 increased heart rate variability 0.000389285556754312 0.00382746174872075 1.19232260566111 1 5.2 5 2 vascular smooth muscle hyperplasia 0.000389285556754312 0.00382746174872075 1.19232260566111 1 5.2 5 2 abnormal spinal cord dorsal column morphology 0.000389285556754312 0.00382746174872075 1.19232260566111 1 5.2 5 2 abnormal cerebellar granule cell migration 0.000389285556754312 0.00382746174872075 1.19232260566111 1 5.2 5 2 thin ventricle myocardium compact layer 0.000389285556754312 0.00382746174872075 1.19232260566111 1 5.2 5 2 abnormal NMDA-mediated synaptic currents 0.000853709644831715 0.00761147936028277 1.19232260566111 1 5.2 5 2 abnormal hippocampus granule cell morphology 0.000853709644831715 0.00761147936028277 1.19232260566111 1 5.2 5 2 decreased effector memory CD4-positive, alpha-beta T cell number 0.000853709644831715 0.00761147936028277 1.19232260566111 1 5.2 5 2 reduced AMPA-mediated synaptic currents 0.000853709644831715 0.00761147936028277 1.19232260566111 1 5.2 5 2 abnormal ductus venosus valve topology 0.000853709644831715 0.00761147936028277 1.19232260566111 1 5.2 5 2 cerebellum atrophy 0.000853709644831715 0.00761147936028277 1.19232260566111 1 5.2 5 2 absent eyelids 0.00187213347433806 0.0146444403063394 1.19232260566111 1 5.2 5 2 decreased aerobic running capacity 0.00187213347433806 0.0146444403063394 1.19232260566111 1 5.2 5 2 abnormal neuron apoptosis 0.00187213347433806 0.0146444403063394 1.19232260566111 1 5.2 5 2 colon polyps 0.00187213347433806 0.0146444403063394 1.19232260566111 1 5.2 5 2 binucleate 0.00187213347433806 0.0146444403063394 1.19232260566111 1 5.2 5 2 abnormal skin development 0.00187213347433806 0.0146444403063394 1.19232260566111 1 5.2 5 2 tau protein deposits 0.00187213347433806 0.0146444403063394 1.19232260566111 1 5.2 5 2 abnormal kidney epithelium morphology 0.00187213347433806 0.0146444403063394 1.19232260566111 1 5.2 5 2 accumulation of giant lysosomes in kidney/renal tubule cells 0.00187213347433806 0.0146444403063394 1.19232260566111 1 5.2 5 2 abnormal meiotic spindle morphology 0.00187213347433806 0.0146444403063394 1.19232260566111 1 5.2 5 2 abnormal stomach position or orientation 0.00187213347433806 0.0146444403063394 1.19232260566111 1 5.2 5 2 impaired neuron differentiation 0.00187213347433806 0.0146444403063394 1.19232260566111 1 5.2 5 2 increased cornea thickness 0.00187213347433806 0.0146444403063394 1.19232260566111 1 5.2 5 2 embryo cyst 0.00187213347433806 0.0146444403063394 1.19232260566111 1 5.2 5 2 increased mammary gland apoptosis 0.00187213347433806 0.0146444403063394 1.19232260566111 1 5.2 5 2 growth retardation of molars 0.00410533077190949 0.0275627808235488 1.19232260566111 1 5.2 5 2 broad head 0.00410533077190949 0.0275627808235488 1.19232260566111 1 5.2 5 2 decreased Schwann cell number 0.00410533077190949 0.0275627808235488 1.19232260566111 1 5.2 5 2 abnormal gastrulation movements 0.00410533077190949 0.0275627808235488 1.19232260566111 1 5.2 5 2 absent tunnel of Corti 0.00410533077190949 0.0275627808235488 1.19232260566111 1 5.2 5 2 aorta coarctation 0.00410533077190949 0.0275627808235488 1.19232260566111 1 5.2 5 2 abnormal nephron morphology 0.00410533077190949 0.0275627808235488 1.19232260566111 1 5.2 5 2 abnormal Purkinje cell innervation 0.00410533077190949 0.0275627808235488 1.19232260566111 1 5.2 5 2 abnormal retina inner limiting membrane morphology 0.00410533077190949 0.0275627808235488 1.19232260566111 1 5.2 5 2 long stride length 0.00410533077190949 0.0275627808235488 1.19232260566111 1 5.2 5 2 abnormal outer hair cell kinocilium morphology 0.00410533077190949 0.0275627808235488 1.19232260566111 1 5.2 5 2 ductus venosus stenosis 0.00410533077190949 0.0275627808235488 1.19232260566111 1 5.2 5 2 echinocytosis 0.00900210816664249 0.0514775725621223 1.19232260566111 1 5.2 5 2 absent ectoplacental cone 0.00900210816664249 0.0514775725621223 1.19232260566111 1 5.2 5 2 chromatolysis 0.00900210816664249 0.0514775725621223 1.19232260566111 1 5.2 5 2 increased post-tetanic potentiation 0.00900210816664249 0.0514775725621223 1.19232260566111 1 5.2 5 2 abnormal hippocampal fimbria morphology 0.00900210816664249 0.0514775725621223 1.19232260566111 1 5.2 5 2 extremity edema 0.00900210816664249 0.0514775725621223 1.19232260566111 1 5.2 5 2 impaired granulosa cell differentiation 0.00900210816664249 0.0514775725621223 1.19232260566111 1 5.2 5 2 increased glycerol level 0.00900210816664249 0.0514775725621223 1.19232260566111 1 5.2 5 2 abnormal metopic suture morphology 0.00900210816664249 0.0514775725621223 1.19232260566111 1 5.2 5 2 absent parietal bone 0.00900210816664249 0.0514775725621223 1.19232260566111 1 5.2 5 2 decreased prostate gland weight 0.00900210816664249 0.0514775725621223 1.19232260566111 1 5.2 5 2 ectopic hippocampus pyramidal cells 0.00900210816664249 0.0514775725621223 1.19232260566111 1 5.2 5 2 increased erythrocyte clearance 0.00900210816664249 0.0514775725621223 1.19232260566111 1 5.2 5 2 cerebral arteriovenous malformation 0.00900210816664249 0.0514775725621223 1.19232260566111 1 5.2 5 2 absent midbrain 0.00900210816664249 0.0514775725621223 1.19232260566111 1 5.2 5 2 delayed limb development 0.00900210816664249 0.0514775725621223 1.19232260566111 1 5.2 5 2 abnormal Wolffian duct connection 0.00900210816664249 0.0514775725621223 1.19232260566111 1 5.2 5 2 decreased hippocampus volume 0.00900210816664249 0.0514775725621223 1.19232260566111 1 5.2 5 2 abnormal excitatory synapse morphology 0.00900210816664249 0.0514775725621223 1.19232260566111 1 5.2 5 2 dissociated hepatocytes 0.0197389945636012 0.0918629541196593 1.19232260566111 1 5.2 5 2 abnormal pineal gland morphology 0.0197389945636012 0.0918629541196593 1.19232260566111 1 5.2 5 2 optic nerve atrophy 0.0197389945636012 0.0918629541196593 1.19232260566111 1 5.2 5 2 absent prostate gland 0.0197389945636012 0.0918629541196593 1.19232260566111 1 5.2 5 2 absent lungs 0.0197389945636012 0.0918629541196593 1.19232260566111 1 5.2 5 2 decreased sensitivity to skin irradiation 0.0197389945636012 0.0918629541196593 1.19232260566111 1 5.2 5 2 skin hyperplasia 0.0197389945636012 0.0918629541196593 1.19232260566111 1 5.2 5 2 corneal scarring 0.0197389945636012 0.0918629541196593 1.19232260566111 1 5.2 5 2 improved righting response 0.0197389945636012 0.0918629541196593 1.19232260566111 1 5.2 5 2 increased urine microalbumin level 0.0197389945636012 0.0918629541196593 1.19232260566111 1 5.2 5 2 decreased lysosomal enzyme secretion 0.0197389945636012 0.0918629541196593 1.19232260566111 1 5.2 5 2 enhanced NMDA-mediated synaptic currents 0.0197389945636012 0.0918629541196593 1.19232260566111 1 5.2 5 2 epidermal cyst 0.0197389945636012 0.0918629541196593 1.19232260566111 1 5.2 5 2 absent frontal bone 0.0197389945636012 0.0918629541196593 1.19232260566111 1 5.2 5 2 erythroblastosis 0.0197389945636012 0.0918629541196593 1.19232260566111 1 5.2 5 2 abnormal olfactory cortex morphology 0.0197389945636012 0.0918629541196593 1.19232260566111 1 5.2 5 2 corneal deposits 0.0197389945636012 0.0918629541196593 1.19232260566111 1 5.2 5 2 absent optic chiasm 0.0197389945636012 0.0918629541196593 1.19232260566111 1 5.2 5 2 enhanced behavioral response to anesthetic 0.0197389945636012 0.0918629541196593 1.19232260566111 1 5.2 5 2 abnormal olfactory bulb granule cell layer morphology 0.0197389945636012 0.0918629541196593 1.19232260566111 1 5.2 5 2 abnormal cerebellum lobule morphology 0.0197389945636012 0.0918629541196593 1.19232260566111 1 5.2 5 2 decreased DN3 thymocyte number 0.0197389945636012 0.0918629541196593 1.19232260566111 1 5.2 5 2 increased thyroid carcinoma incidence 0.0197389945636012 0.0918629541196593 1.19232260566111 1 5.2 5 2 aorta hypoplasia 0.0197389945636012 0.0918629541196593 1.19232260566111 1 5.2 5 2 enlarged aortic valve 0.0197389945636012 0.0918629541196593 1.19232260566111 1 5.2 5 2 increased Schwann cell number 0.0197389945636012 0.0918629541196593 1.19232260566111 1 5.2 5 2 pale lung 0.0197389945636012 0.0918629541196593 1.19232260566111 1 5.2 5 2 fused right lung lobes 0.0197389945636012 0.0918629541196593 1.19232260566111 1 5.2 5 2 abnormal lung alveolus development 0.0197389945636012 0.0918629541196593 1.19232260566111 1 5.2 5 2 decreased pre-pro B cell number 0.0197389945636012 0.0918629541196593 1.19232260566111 1 5.2 5 2 cerebral edema 0.0197389945636012 0.0918629541196593 1.19232260566111 1 5.2 5 2 absent foregut 0.0197389945636012 0.0918629541196593 1.19232260566111 1 5.2 5 2 abnormal mitophagy 0.0197389945636012 0.0918629541196593 1.19232260566111 1 5.2 5 2 decreased small intestinal villus height 0.0197389945636012 0.0918629541196593 1.19232260566111 1 5.2 5 2 absent long term depression 4.56568526904418e-09 1.76079722585231e-07 1.15120803305211 0.96551724137931 5.2 5 2 abnormal postnatal subventricular zone morphology 3.75651658560542e-06 7.53575403765603e-05 1.13270647537805 0.95 5.2 5 2 abnormal mitral valve morphology 1.63411955643526e-05 0.000275584569263235 1.12608246090216 0.944444444444444 5.2 5 2 impaired synaptic plasticity 2.1195090619117e-09 8.64307998607434e-08 1.12218598179869 0.941176470588235 5.2 5 2 absence seizures 3.3941598374306e-05 0.000502557892595751 1.12218598179869 0.941176470588235 5.2 5 2 abnormal involuntary movement 3.3941598374306e-05 0.000502557892595751 1.12218598179869 0.941176470588235 5.2 5 2 abnormal embryonic-extraembryonic boundary morphology 3.3941598374306e-05 0.000502557892595751 1.12218598179869 0.941176470588235 5.2 5 2 abnormal synaptic transmission 3.83808416002501e-08 1.22400440359772e-06 1.11283443195037 0.933333333333333 5.2 5 2 abnormal pup retrieval 0.000144982370135212 0.00170517090170846 1.11283443195037 0.933333333333333 5.2 5 2 abnormal secondary palate development 0.000144982370135212 0.00170517090170846 1.11283443195037 0.933333333333333 5.2 5 2 myoclonus 1.61263942587571e-07 4.48205650487803e-06 1.10715670525674 0.928571428571429 5.2 5 2 abnormal voluntary movement 0.000297907823897481 0.0030812711515384 1.10715670525674 0.928571428571429 5.2 5 2 testis degeneration 0.000297907823897481 0.0030812711515384 1.10715670525674 0.928571428571429 5.2 5 2 multiple persisting craniopharyngeal ducts 0.000297907823897481 0.0030812711515384 1.10715670525674 0.928571428571429 5.2 5 2 decreased susceptibility to pharmacologically induced seizures 3.29341249634947e-07 8.44573565429826e-06 1.10400241264917 0.925925925925926 5.2 5 2 increased synaptic depression 0.000609335507351946 0.00567686170238938 1.10060548214872 0.923076923076923 5.2 5 2 abnormal coping response 0.000609335507351946 0.00567686170238938 1.10060548214872 0.923076923076923 5.2 5 2 abnormal adipose tissue distribution 0.00123977287935903 0.0104540170759512 1.09296238852268 0.916666666666667 5.2 5 2 decreased synaptic depression 0.00123977287935903 0.0104540170759512 1.09296238852268 0.916666666666667 5.2 5 2 absent ovary 0.00123977287935903 0.0104540170759512 1.09296238852268 0.916666666666667 5.2 5 2 prenatal growth retardation 0.00123977287935903 0.0104540170759512 1.09296238852268 0.916666666666667 5.2 5 2 abnormal tail movements 1.11854880522283e-05 0.000199454491253891 1.0839296415101 0.909090909090909 5.2 5 2 abnormal hemoglobin 0.0025070889777949 0.018396412484557 1.0839296415101 0.909090909090909 5.2 5 2 failure of somite differentiation 0.0025070889777949 0.018396412484557 1.0839296415101 0.909090909090909 5.2 5 2 pharyngeal arch hypoplasia 0.0025070889777949 0.018396412484557 1.0839296415101 0.909090909090909 5.2 5 2 abnormal dorsal-ventral polarity of the somites 0.0025070889777949 0.018396412484557 1.0839296415101 0.909090909090909 5.2 5 2 common atrioventricular valve 0.0025070889777949 0.018396412484557 1.0839296415101 0.909090909090909 5.2 5 2 thin hypoglossal nerve 0.0025070889777949 0.018396412484557 1.0839296415101 0.909090909090909 5.2 5 2 reduced sympathetic cervical ganglion size 0.0025070889777949 0.018396412484557 1.0839296415101 0.909090909090909 5.2 5 2 enhanced paired-pulse facilitation 4.42227545813426e-07 1.10891043569483e-05 1.073090345095 0.9 5.2 5 2 decreased paired-pulse facilitation 4.46416567005802e-05 0.000643672924553109 1.073090345095 0.9 5.2 5 2 increased cranium width 0.00503352643752834 0.0319410638095708 1.073090345095 0.9 5.2 5 2 alcohol preference 0.00503352643752834 0.0319410638095708 1.073090345095 0.9 5.2 5 2 decreased incidence of induced tumors 0.00503352643752834 0.0319410638095708 1.073090345095 0.9 5.2 5 2 impaired basement membrane formation 0.00503352643752834 0.0319410638095708 1.073090345095 0.9 5.2 5 2 bifid ureter 0.00503352643752834 0.0319410638095708 1.073090345095 0.9 5.2 5 2 abnormal pillar cell morphology 0.00503352643752834 0.0319410638095708 1.073090345095 0.9 5.2 5 2 abnormal plasma membrane morphology 0.00503352643752834 0.0319410638095708 1.073090345095 0.9 5.2 5 2 osteosclerosis 0.00503352643752834 0.0319410638095708 1.073090345095 0.9 5.2 5 2 abnormal hippocampus neuron morphology 0.00503352643752834 0.0319410638095708 1.073090345095 0.9 5.2 5 2 fusion of atlas and odontoid process 0.00503352643752834 0.0319410638095708 1.073090345095 0.9 5.2 5 2 abnormal long term depression 8.85585977859754e-05 0.00113398156569034 1.06681496295994 0.894736842105263 5.2 5 2 abnormal digestive system development 8.85585977859754e-05 0.00113398156569034 1.06681496295994 0.894736842105263 5.2 5 2 failure to gastrulate 7.44347077256605e-10 3.39736395353359e-08 1.06272232243708 0.891304347826087 5.2 5 2 reduced long term depression 6.95381055109936e-08 2.09667924192238e-06 1.05984231614321 0.888888888888889 5.2 5 2 absent spleen 0.000174744820853933 0.00195800784627999 1.05984231614321 0.888888888888889 5.2 5 2 abnormal thymus cortex morphology 0.000174744820853933 0.00195800784627999 1.05984231614321 0.888888888888889 5.2 5 2 abnormal thymus medulla morphology 0.000174744820853933 0.00195800784627999 1.05984231614321 0.888888888888889 5.2 5 2 abnormal body wall morphology 0.000174744820853933 0.00195800784627999 1.05984231614321 0.888888888888889 5.2 5 2 darkened coat color 0.000174744820853933 0.00195800784627999 1.05984231614321 0.888888888888889 5.2 5 2 decreased lactate dehydrogenase level 0.000174744820853933 0.00195800784627999 1.05984231614321 0.888888888888889 5.2 5 2 increased effector memory CD4-positive, alpha-beta T cell number 0.000174744820853933 0.00195800784627999 1.05984231614321 0.888888888888889 5.2 5 2 abnormal hypoglossal nerve topology 0.000174744820853933 0.00195800784627999 1.05984231614321 0.888888888888889 5.2 5 2 abnormal head movements 0.0100195241103888 0.0548373294270455 1.05984231614321 0.888888888888889 5.2 5 2 thick tail 0.0100195241103888 0.0548373294270455 1.05984231614321 0.888888888888889 5.2 5 2 abnormal ion homeostasis 0.0100195241103888 0.0548373294270455 1.05984231614321 0.888888888888889 5.2 5 2 abnormal abdominal wall morphology 0.0100195241103888 0.0548373294270455 1.05984231614321 0.888888888888889 5.2 5 2 pancreas cysts 0.0100195241103888 0.0548373294270455 1.05984231614321 0.888888888888889 5.2 5 2 decreased cellular sensitivity to ionizing radiation 0.0100195241103888 0.0548373294270455 1.05984231614321 0.888888888888889 5.2 5 2 small scapula 0.0100195241103888 0.0548373294270455 1.05984231614321 0.888888888888889 5.2 5 2 increased neuronal precursor cell number 0.0100195241103888 0.0548373294270455 1.05984231614321 0.888888888888889 5.2 5 2 abnormal intervertebral disk development 0.0100195241103888 0.0548373294270455 1.05984231614321 0.888888888888889 5.2 5 2 retropulsion 0.0100195241103888 0.0548373294270455 1.05984231614321 0.888888888888889 5.2 5 2 abnormal oxidative phosphorylation 0.0100195241103888 0.0548373294270455 1.05984231614321 0.888888888888889 5.2 5 2 trigeminal neuroma 0.0100195241103888 0.0548373294270455 1.05984231614321 0.888888888888889 5.2 5 2 abnormal coronary sinus connection 0.0100195241103888 0.0548373294270455 1.05984231614321 0.888888888888889 5.2 5 2 increased cardiac muscle glycogen level 0.0100195241103888 0.0548373294270455 1.05984231614321 0.888888888888889 5.2 5 2 abnormal axon guidance 5.57305776637649e-09 2.11648567845214e-07 1.05368044221214 0.883720930232558 5.2 5 2 abnormal dorsal-ventral axis patterning 0.000342772367804198 0.00344503541378967 1.05204935793627 0.882352941176471 5.2 5 2 coloboma 0.000342772367804198 0.00344503541378967 1.05204935793627 0.882352941176471 5.2 5 2 enhanced behavioral response to cocaine 0.000342772367804198 0.00344503541378967 1.05204935793627 0.882352941176471 5.2 5 2 increased trabecular bone mass 0.000342772367804198 0.00344503541378967 1.05204935793627 0.882352941176471 5.2 5 2 increased cellular sensitivity to ionizing radiation 1.29923222950032e-05 0.000226795801465406 1.04924389298178 0.88 5.2 5 2 abnormal depression-related behavior 9.98777677439477e-07 2.27932061709238e-05 1.04328227995347 0.875 5.2 5 2 abnormal impulse conducting system conduction 2.52096962152596e-05 0.000393160622792841 1.04328227995347 0.875 5.2 5 2 intraventricular hemorrhage 0.000667936550578112 0.00613096741536182 1.04328227995347 0.875 5.2 5 2 increased cochlear outer hair cell number 0.000667936550578112 0.00613096741536182 1.04328227995347 0.875 5.2 5 2 embryonic lethality between somite formation and embryo turning, incomplete penetrance 0.000667936550578112 0.00613096741536182 1.04328227995347 0.875 5.2 5 2 abnormal bone marrow development 0.0197377118549094 0.0918629541196593 1.04328227995347 0.875 5.2 5 2 abnormal vagus ganglion morphology 0.0197377118549094 0.0918629541196593 1.04328227995347 0.875 5.2 5 2 poor grooming 0.0197377118549094 0.0918629541196593 1.04328227995347 0.875 5.2 5 2 abnormal secondary sex determination 0.0197377118549094 0.0918629541196593 1.04328227995347 0.875 5.2 5 2 loss of GABAergic neurons 0.0197377118549094 0.0918629541196593 1.04328227995347 0.875 5.2 5 2 liver cysts 0.0197377118549094 0.0918629541196593 1.04328227995347 0.875 5.2 5 2 elevated level of mitotic sister chromatid exchange 0.0197377118549094 0.0918629541196593 1.04328227995347 0.875 5.2 5 2 abnormal extraembryonic tissue physiology 0.0197377118549094 0.0918629541196593 1.04328227995347 0.875 5.2 5 2 absent interparietal bone 0.0197377118549094 0.0918629541196593 1.04328227995347 0.875 5.2 5 2 absent cochlear microphonics 0.0197377118549094 0.0918629541196593 1.04328227995347 0.875 5.2 5 2 abnormal somite size 0.0197377118549094 0.0918629541196593 1.04328227995347 0.875 5.2 5 2 ocular hypertension 0.0197377118549094 0.0918629541196593 1.04328227995347 0.875 5.2 5 2 craniofacial phenotype 0.0197377118549094 0.0918629541196593 1.04328227995347 0.875 5.2 5 2 impaired behavioral response to alcohol 0.0197377118549094 0.0918629541196593 1.04328227995347 0.875 5.2 5 2 abnormal olfactory bulb glomerular layer morphology 0.0197377118549094 0.0918629541196593 1.04328227995347 0.875 5.2 5 2 abnormal olfactory bulb mitral cell layer morphology 0.0197377118549094 0.0918629541196593 1.04328227995347 0.875 5.2 5 2 decreased hippocampus pyramidal cell number 0.0197377118549094 0.0918629541196593 1.04328227995347 0.875 5.2 5 2 increased caudal vertebrae number 0.0197377118549094 0.0918629541196593 1.04328227995347 0.875 5.2 5 2 pleural effusion 0.0197377118549094 0.0918629541196593 1.04328227995347 0.875 5.2 5 2 lung situs inversus 0.0197377118549094 0.0918629541196593 1.04328227995347 0.875 5.2 5 2 abnormal anterior commissure pars posterior morphology 0.0197377118549094 0.0918629541196593 1.04328227995347 0.875 5.2 5 2 decreased alveolar lamellar body number 0.0197377118549094 0.0918629541196593 1.04328227995347 0.875 5.2 5 2 abnormal maxillary prominence morphology 0.0197377118549094 0.0918629541196593 1.04328227995347 0.875 5.2 5 2 decreased cranium length 0.0197377118549094 0.0918629541196593 1.04328227995347 0.875 5.2 5 2 prolonged PQ interval 0.0197377118549094 0.0918629541196593 1.04328227995347 0.875 5.2 5 2 retropleural edema 0.0197377118549094 0.0918629541196593 1.04328227995347 0.875 5.2 5 2 limb grasping 3.61187936040401e-32 1.19793998786733e-29 1.04164447417646 0.873626373626374 5.2 5 2 abnormal fontanelle morphology 0.00129192327335223 0.0107840910820929 1.03334625823963 0.866666666666667 5.2 5 2 delayed intramembranous bone ossification 0.00129192327335223 0.0107840910820929 1.03334625823963 0.866666666666667 5.2 5 2 decreased aggression towards males 0.00129192327335223 0.0107840910820929 1.03334625823963 0.866666666666667 5.2 5 2 abnormal Muller cell morphology 0.00129192327335223 0.0107840910820929 1.03334625823963 0.866666666666667 5.2 5 2 heterochrony 0.00129192327335223 0.0107840910820929 1.03334625823963 0.866666666666667 5.2 5 2 abnormal brain wave pattern 9.56169850929293e-10 4.2096858481179e-08 1.03181763951442 0.865384615384615 5.2 5 2 malocclusion 2.87911372183043e-07 7.53873198216127e-06 1.03119792922042 0.864864864864865 5.2 5 2 muscular atrophy 2.27782673046481e-08 7.70897141772953e-07 1.02973315943459 0.863636363636364 5.2 5 2 intracerebral hemorrhage 9.3388918269693e-05 0.00116736147837116 1.02973315943459 0.863636363636364 5.2 5 2 aphakia 9.3388918269693e-05 0.00116736147837116 1.02973315943459 0.863636363636364 5.2 5 2 abnormal cerebral cortex pyramidal cell morphology 9.3388918269693e-05 0.00116736147837116 1.02973315943459 0.863636363636364 5.2 5 2 abnormal embryonic neuroepithelium morphology 1.46927789346312e-10 7.45883420406021e-09 1.02786431522509 0.862068965517241 5.2 5 2 abnormal excitatory postsynaptic currents 1.50566147403973e-13 1.22797800546683e-11 1.02417454588839 0.858974358974359 5.2 5 2 abnormal CNS synaptic transmission 8.35556182764603e-17 1.12348432682538e-14 1.02371132809287 0.858585858585859 5.2 5 2 absent corpus callosum 1.34363795320525e-05 0.000232912850773385 1.02199080485238 0.857142857142857 5.2 5 2 embryonic lethality at implantation, complete penetrance 0.000178121316594585 0.0019744035002372 1.02199080485238 0.857142857142857 5.2 5 2 absent segment of posterior cerebral artery 0.000178121316594585 0.0019744035002372 1.02199080485238 0.857142857142857 5.2 5 2 abnormal adrenal gland secretion 0.00247790160807874 0.018396412484557 1.02199080485238 0.857142857142857 5.2 5 2 amyloid beta deposits 0.00247790160807874 0.018396412484557 1.02199080485238 0.857142857142857 5.2 5 2 absent olfactory bulb 0.00247790160807874 0.018396412484557 1.02199080485238 0.857142857142857 5.2 5 2 skeletal muscle necrosis 0.00247790160807874 0.018396412484557 1.02199080485238 0.857142857142857 5.2 5 2 abnormal renal tubule epithelial cell primary cilium morphology 0.00247790160807874 0.018396412484557 1.02199080485238 0.857142857142857 5.2 5 2 abnormal vitelline vein topology 0.00247790160807874 0.018396412484557 1.02199080485238 0.857142857142857 5.2 5 2 cochlear degeneration 0.0383827725350405 0.154177544636462 1.02199080485238 0.857142857142857 5.2 5 2 failure of atrioventricular cushion closure 0.0383827725350405 0.154177544636462 1.02199080485238 0.857142857142857 5.2 5 2 absent hair follicles 0.0383827725350405 0.154177544636462 1.02199080485238 0.857142857142857 5.2 5 2 maxilla hypoplasia 0.0383827725350405 0.154177544636462 1.02199080485238 0.857142857142857 5.2 5 2 mammary gland hyperplasia 0.0383827725350405 0.154177544636462 1.02199080485238 0.857142857142857 5.2 5 2 abnormal oculomotor nerve morphology 0.0383827725350405 0.154177544636462 1.02199080485238 0.857142857142857 5.2 5 2 retina hyperplasia 0.0383827725350405 0.154177544636462 1.02199080485238 0.857142857142857 5.2 5 2 excessive tearing 0.0383827725350405 0.154177544636462 1.02199080485238 0.857142857142857 5.2 5 2 limp posture 0.0383827725350405 0.154177544636462 1.02199080485238 0.857142857142857 5.2 5 2 abnormal axial mesoderm 0.0383827725350405 0.154177544636462 1.02199080485238 0.857142857142857 5.2 5 2 absent amniotic folds 0.0383827725350405 0.154177544636462 1.02199080485238 0.857142857142857 5.2 5 2 abnormal tumor incidence 0.0383827725350405 0.154177544636462 1.02199080485238 0.857142857142857 5.2 5 2 abnormal adrenal gland physiology 0.0383827725350405 0.154177544636462 1.02199080485238 0.857142857142857 5.2 5 2 decreased mortality induced by ionizing radiation 0.0383827725350405 0.154177544636462 1.02199080485238 0.857142857142857 5.2 5 2 increased muscle weight 0.0383827725350405 0.154177544636462 1.02199080485238 0.857142857142857 5.2 5 2 abnormal central pattern generator function 0.0383827725350405 0.154177544636462 1.02199080485238 0.857142857142857 5.2 5 2 abnormal optic tract morphology 0.0383827725350405 0.154177544636462 1.02199080485238 0.857142857142857 5.2 5 2 abnormal organ of Corti supporting cell morphology 0.0383827725350405 0.154177544636462 1.02199080485238 0.857142857142857 5.2 5 2 absent deltoid tuberosity 0.0383827725350405 0.154177544636462 1.02199080485238 0.857142857142857 5.2 5 2 absent ulna 0.0383827725350405 0.154177544636462 1.02199080485238 0.857142857142857 5.2 5 2 abnormal cochlear nerve compound action potential 0.0383827725350405 0.154177544636462 1.02199080485238 0.857142857142857 5.2 5 2 abnormal ciliary body morphology 0.0383827725350405 0.154177544636462 1.02199080485238 0.857142857142857 5.2 5 2 absent fibula 0.0383827725350405 0.154177544636462 1.02199080485238 0.857142857142857 5.2 5 2 abnormal uterus physiology 0.0383827725350405 0.154177544636462 1.02199080485238 0.857142857142857 5.2 5 2 abnormal spinal cord central canal morphology 0.0383827725350405 0.154177544636462 1.02199080485238 0.857142857142857 5.2 5 2 heart hemorrhage 0.0383827725350405 0.154177544636462 1.02199080485238 0.857142857142857 5.2 5 2 decreased DN2 thymocyte number 0.0383827725350405 0.154177544636462 1.02199080485238 0.857142857142857 5.2 5 2 decreased skeletal muscle glycogen level 0.0383827725350405 0.154177544636462 1.02199080485238 0.857142857142857 5.2 5 2 abnormal conotruncal ridge morphology 0.0383827725350405 0.154177544636462 1.02199080485238 0.857142857142857 5.2 5 2 abnormal aortic valve cusp morphology 0.0383827725350405 0.154177544636462 1.02199080485238 0.857142857142857 5.2 5 2 increased compact bone volume 0.0383827725350405 0.154177544636462 1.02199080485238 0.857142857142857 5.2 5 2 embryonic lethality at implantation, incomplete penetrance 0.0383827725350405 0.154177544636462 1.02199080485238 0.857142857142857 5.2 5 2 absent heart tube 0.0383827725350405 0.154177544636462 1.02199080485238 0.857142857142857 5.2 5 2 decreased circulating total protein level 9.9667946187467e-10 4.27679321371685e-08 1.01889386301949 0.854545454545454 5.2 5 2 enlarged liver sinusoidal spaces 1.96842230494206e-06 4.25778302916816e-05 1.01698104600506 0.852941176470588 5.2 5 2 abnormal atrioventricular cushion morphology 2.54154180469435e-05 0.000395130327448575 1.01568221963724 0.851851851851852 5.2 5 2 abnormal posture 2.9257228413381e-13 2.31039224375508e-11 1.01347421481194 0.85 5.2 5 2 small gonad 0.000337421263936547 0.00341888144212693 1.01347421481194 0.85 5.2 5 2 anencephaly 0.000337421263936547 0.00341888144212693 1.01347421481194 0.85 5.2 5 2 abnormal dopamine level 0.000337421263936547 0.00341888144212693 1.01347421481194 0.85 5.2 5 2 spleen atrophy 0.000337421263936547 0.00341888144212693 1.01347421481194 0.85 5.2 5 2 abnormal response to tactile stimuli 0.000337421263936547 0.00341888144212693 1.01347421481194 0.85 5.2 5 2 increased skin tumor incidence 0.000337421263936547 0.00341888144212693 1.01347421481194 0.85 5.2 5 2 abnormal ureter morphology 4.78007014488353e-05 0.00068335772904585 1.00888835863632 0.846153846153846 5.2 5 2 abnormal nerve conduction 4.78007014488353e-05 0.00068335772904585 1.00888835863632 0.846153846153846 5.2 5 2 increased foot pad pigmentation 0.00470717842539801 0.030256088716221 1.00888835863632 0.846153846153846 5.2 5 2 abnormal afterhyperpolarization 0.00470717842539801 0.030256088716221 1.00888835863632 0.846153846153846 5.2 5 2 abnormal retinal inner plexiform layer morphology 0.00470717842539801 0.030256088716221 1.00888835863632 0.846153846153846 5.2 5 2 abnormal vertebral arch development 0.00470717842539801 0.030256088716221 1.00888835863632 0.846153846153846 5.2 5 2 abnormal aorta tunica media morphology 0.00470717842539801 0.030256088716221 1.00888835863632 0.846153846153846 5.2 5 2 absent hypoglossal nerve 0.00470717842539801 0.030256088716221 1.00888835863632 0.846153846153846 5.2 5 2 kyphoscoliosis 0.000634404677216375 0.0058555904808005 1.00406114160936 0.842105263157895 5.2 5 2 abnormal sternebra morphology 0.000634404677216375 0.0058555904808005 1.00406114160936 0.842105263157895 5.2 5 2 embryonic lethality between implantation and somite formation, incomplete penetrance 0.000634404677216375 0.0058555904808005 1.00406114160936 0.842105263157895 5.2 5 2 abnormal excitatory postsynaptic potential 5.43412742130701e-13 4.22418498765662e-11 1.00329585110508 0.841463414634146 5.2 5 2 abnormal nest building behavior 8.93509092966057e-05 0.00113398156569034 1.00155098875533 0.84 5.2 5 2 abnormal egg cylinder morphology 8.93509092966057e-05 0.00113398156569034 1.00155098875533 0.84 5.2 5 2 abnormal cochlear outer hair cell morphology 8.93509092966057e-05 0.00113398156569034 1.00155098875533 0.84 5.2 5 2 abnormal object recognition memory 1.29094535799702e-05 0.000226142716761801 1.00001250797383 0.838709677419355 5.2 5 2 abnormal postnatal growth/weight/body size 1.29094535799702e-05 0.000226142716761801 1.00001250797383 0.838709677419355 5.2 5 2 abnormal inhibitory postsynaptic currents 7.95878070466595e-11 4.32246863753509e-09 0.999446890039459 0.838235294117647 5.2 5 2 decreased width of hypertrophic chondrocyte zone 1.89632199446434e-06 4.13780786072811e-05 0.99897299393228 0.837837837837838 5.2 5 2 abnormal heart tube morphology 2.39079878407594e-05 0.000374032199709993 0.993602171384258 0.833333333333333 5.2 5 2 abnormal optic cup morphology 2.39079878407594e-05 0.000374032199709993 0.993602171384258 0.833333333333333 5.2 5 2 abnormal heart shape 0.00118291010255553 0.0100426241641873 0.993602171384258 0.833333333333333 5.2 5 2 delayed kidney development 0.00118291010255553 0.0100426241641873 0.993602171384258 0.833333333333333 5.2 5 2 right pulmonary isomerism 0.00118291010255553 0.0100426241641873 0.993602171384258 0.833333333333333 5.2 5 2 decreased cellular sensitivity to gamma-irradiation 0.00118291010255553 0.0100426241641873 0.993602171384258 0.833333333333333 5.2 5 2 decreased pulmonary respiratory rate 0.00118291010255553 0.0100426241641873 0.993602171384258 0.833333333333333 5.2 5 2 abnormal apoptosis 1.17413769130056e-08 4.14279079022717e-07 0.993602171384257 0.833333333333333 5.2 5 2 axon degeneration 1.17413769130056e-08 4.14279079022717e-07 0.993602171384257 0.833333333333333 5.2 5 2 vertebral transformation 7.78996613759681e-08 2.32066356494276e-06 0.993602171384257 0.833333333333333 5.2 5 2 abnormal reproductive system morphology 5.20286456141923e-07 1.27508626566801e-05 0.993602171384257 0.833333333333333 5.2 5 2 ocular hypertelorism 0.000165910299519105 0.00190624420348164 0.993602171384257 0.833333333333333 5.2 5 2 hemolytic anemia 0.000165910299519105 0.00190624420348164 0.993602171384257 0.833333333333333 5.2 5 2 abnormal sensory capabilities/reflexes/nociception 0.000165910299519105 0.00190624420348164 0.993602171384257 0.833333333333333 5.2 5 2 increased hemangiosarcoma incidence 0.000165910299519105 0.00190624420348164 0.993602171384257 0.833333333333333 5.2 5 2 abnormal supraoccipital bone morphology 0.00884366946997425 0.0514775725621223 0.993602171384257 0.833333333333333 5.2 5 2 abnormal mating frequency 0.00884366946997425 0.0514775725621223 0.993602171384257 0.833333333333333 5.2 5 2 myocarditis 0.00884366946997425 0.0514775725621223 0.993602171384257 0.833333333333333 5.2 5 2 abnormal respiratory function 0.00884366946997425 0.0514775725621223 0.993602171384257 0.833333333333333 5.2 5 2 dilated bile duct 0.00884366946997425 0.0514775725621223 0.993602171384257 0.833333333333333 5.2 5 2 abnormal rostral-caudal body axis extension 0.00884366946997425 0.0514775725621223 0.993602171384257 0.833333333333333 5.2 5 2 pale placenta 0.00884366946997425 0.0514775725621223 0.993602171384257 0.833333333333333 5.2 5 2 abnormal cochlear outer hair cell physiology 0.00884366946997425 0.0514775725621223 0.993602171384257 0.833333333333333 5.2 5 2 abnormal somatic nervous system physiology 0.00884366946997425 0.0514775725621223 0.993602171384257 0.833333333333333 5.2 5 2 abnormal behavioral response to addictive substance 0.00884366946997425 0.0514775725621223 0.993602171384257 0.833333333333333 5.2 5 2 abnormal vitelline vein connection 0.00884366946997425 0.0514775725621223 0.993602171384257 0.833333333333333 5.2 5 2 shiny fur 0.0734234265483946 0.238278895680537 0.993602171384257 0.833333333333333 5.2 5 2 abnormal urethra morphology 0.0734234265483946 0.238278895680537 0.993602171384257 0.833333333333333 5.2 5 2 absent limbs 0.0734234265483946 0.238278895680537 0.993602171384257 0.833333333333333 5.2 5 2 thin tail 0.0734234265483946 0.238278895680537 0.993602171384257 0.833333333333333 5.2 5 2 abnormal lacrimal gland physiology 0.0734234265483946 0.238278895680537 0.993602171384257 0.833333333333333 5.2 5 2 hyperresponsive 0.0734234265483946 0.238278895680537 0.993602171384257 0.833333333333333 5.2 5 2 jumpy 0.0734234265483946 0.238278895680537 0.993602171384257 0.833333333333333 5.2 5 2 abnormal avoidance learning behavior 0.0734234265483946 0.238278895680537 0.993602171384257 0.833333333333333 5.2 5 2 delayed brain development 0.0734234265483946 0.238278895680537 0.993602171384257 0.833333333333333 5.2 5 2 non-obstructive hydrocephaly 0.0734234265483946 0.238278895680537 0.993602171384257 0.833333333333333 5.2 5 2 reduced NMDA-mediated synaptic currents 0.0734234265483946 0.238278895680537 0.993602171384257 0.833333333333333 5.2 5 2 abnormal parental behavior 0.0734234265483946 0.238278895680537 0.993602171384257 0.833333333333333 5.2 5 2 phenotypic reversion 0.0734234265483946 0.238278895680537 0.993602171384257 0.833333333333333 5.2 5 2 loss of hippocampal neurons 0.0734234265483946 0.238278895680537 0.993602171384257 0.833333333333333 5.2 5 2 abnormal intestinal peristalsis 0.0734234265483946 0.238278895680537 0.993602171384257 0.833333333333333 5.2 5 2 pancreas fibrosis 0.0734234265483946 0.238278895680537 0.993602171384257 0.833333333333333 5.2 5 2 enlarged pancreas 0.0734234265483946 0.238278895680537 0.993602171384257 0.833333333333333 5.2 5 2 ureter obstruction 0.0734234265483946 0.238278895680537 0.993602171384257 0.833333333333333 5.2 5 2 absent molars 0.0734234265483946 0.238278895680537 0.993602171384257 0.833333333333333 5.2 5 2 abnormal cholesterol level 0.0734234265483946 0.238278895680537 0.993602171384257 0.833333333333333 5.2 5 2 abnormal physical strength 0.0734234265483946 0.238278895680537 0.993602171384257 0.833333333333333 5.2 5 2 small clavicle 0.0734234265483946 0.238278895680537 0.993602171384257 0.833333333333333 5.2 5 2 bowed humerus 0.0734234265483946 0.238278895680537 0.993602171384257 0.833333333333333 5.2 5 2 abnormal common crus morphology 0.0734234265483946 0.238278895680537 0.993602171384257 0.833333333333333 5.2 5 2 abnormal blastocoele morphology 0.0734234265483946 0.238278895680537 0.993602171384257 0.833333333333333 5.2 5 2 abnormal immature B cell morphology 0.0734234265483946 0.238278895680537 0.993602171384257 0.833333333333333 5.2 5 2 abnormal heart size 0.0734234265483946 0.238278895680537 0.993602171384257 0.833333333333333 5.2 5 2 abnormal pulmonary respiratory rate 0.0734234265483946 0.238278895680537 0.993602171384257 0.833333333333333 5.2 5 2 delayed chorioallantoic fusion 0.0734234265483946 0.238278895680537 0.993602171384257 0.833333333333333 5.2 5 2 abnormal neural crest cell morphology 0.0734234265483946 0.238278895680537 0.993602171384257 0.833333333333333 5.2 5 2 abnormal aorta tunica adventitia morphology 0.0734234265483946 0.238278895680537 0.993602171384257 0.833333333333333 5.2 5 2 increased transitional stage T1 B cell number 0.0734234265483946 0.238278895680537 0.993602171384257 0.833333333333333 5.2 5 2 abnormal olfactory bulb layer morphology 0.0734234265483946 0.238278895680537 0.993602171384257 0.833333333333333 5.2 5 2 abnormal acute phase protein level 0.0734234265483946 0.238278895680537 0.993602171384257 0.833333333333333 5.2 5 2 decreased macrophage nitric oxide production 0.0734234265483946 0.238278895680537 0.993602171384257 0.833333333333333 5.2 5 2 abnormal ureteric bud tip morphology 0.0734234265483946 0.238278895680537 0.993602171384257 0.833333333333333 5.2 5 2 abnormal kidney collecting duct epithelium morphology 0.0734234265483946 0.238278895680537 0.993602171384257 0.833333333333333 5.2 5 2 abnormal circulating osteocalcin level 0.0734234265483946 0.238278895680537 0.993602171384257 0.833333333333333 5.2 5 2 increased bone trabecular spacing 0.0734234265483946 0.238278895680537 0.993602171384257 0.833333333333333 5.2 5 2 increased CD11b-high dendritic cell number 0.0734234265483946 0.238278895680537 0.993602171384257 0.833333333333333 5.2 5 2 absent thymus corticomedullary boundary 0.0734234265483946 0.238278895680537 0.993602171384257 0.833333333333333 5.2 5 2 ciliary body hypoplasia 0.0734234265483946 0.238278895680537 0.993602171384257 0.833333333333333 5.2 5 2 increased effector memory T-helper cell number 0.0734234265483946 0.238278895680537 0.993602171384257 0.833333333333333 5.2 5 2 abnormal vertebral artery origin 0.0734234265483946 0.238278895680537 0.993602171384257 0.833333333333333 5.2 5 2 additional anastomosis between intracranial vertebral arteries 0.0734234265483946 0.238278895680537 0.993602171384257 0.833333333333333 5.2 5 2 abnormal platelet alpha-granule morphology 0.0734234265483946 0.238278895680537 0.993602171384257 0.833333333333333 5.2 5 2 abnormal inhibitory learning 0.0734234265483946 0.238278895680537 0.993602171384257 0.833333333333333 5.2 5 2 reduced long term potentiation 2.82991053121741e-16 3.27414067274573e-14 0.990053592200742 0.830357142857143 5.2 5 2 abnormal liver development 6.44826326772284e-06 0.000120601916379403 0.987924444690633 0.828571428571429 5.2 5 2 abnormal spinal nerve morphology 4.40150169796582e-05 0.000636554388005232 0.98674974261609 0.827586206896552 5.2 5 2 embryonic lethality, complete penetrance 4.24556711372069e-43 2.34685515452894e-40 0.98674974261609 0.827586206896552 5.2 5 2 liver hypoplasia 3.94714117418092e-08 1.24284983174368e-06 0.985959077758225 0.826923076923077 5.2 5 2 abnormal placenta vasculature 3.94714117418092e-08 1.24284983174368e-06 0.985959077758225 0.826923076923077 5.2 5 2 abnormal cell death 2.61933587452096e-07 6.93148722113924e-06 0.984962152502655 0.826086956521739 5.2 5 2 atrial septal defect 2.61933587452096e-07 6.93148722113924e-06 0.984962152502655 0.826086956521739 5.2 5 2 decreased brain weight 1.09076805216153e-08 3.9040079564774e-07 0.98314320115916 0.824561403508772 5.2 5 2 abnormal axon morphology 3.13321660483276e-15 3.11755052180859e-13 0.982562147257766 0.824074074074074 5.2 5 2 impaired balance 2.02599379681647e-14 1.86654058132628e-12 0.981912734073854 0.823529411764706 5.2 5 2 abnormal cued conditioning behavior 7.19687372684359e-08 2.15689438500282e-06 0.981912734073854 0.823529411764706 5.2 5 2 abnormal interatrial septum morphology 0.00218536940352304 0.0165734950953157 0.981912734073854 0.823529411764706 5.2 5 2 abnormal testis development 0.00218536940352304 0.0165734950953157 0.981912734073854 0.823529411764706 5.2 5 2 increased brain size 0.00218536940352304 0.0165734950953157 0.981912734073854 0.823529411764706 5.2 5 2 abnormal ductus venosus valve morphology 0.00218536940352304 0.0165734950953157 0.981912734073854 0.823529411764706 5.2 5 2 irregular heartbeat 4.77308412775879e-07 1.18139768833831e-05 0.980354142432467 0.822222222222222 5.2 5 2 lethality at weaning, complete penetrance 4.77308412775879e-07 1.18139768833831e-05 0.980354142432467 0.822222222222222 5.2 5 2 ataxia 6.49921740939542e-27 1.79631147843012e-24 0.979829468018535 0.821782178217822 5.2 5 2 enhanced long term potentiation 1.9828089357209e-08 6.80308583118032e-07 0.979407854650197 0.821428571428571 5.2 5 2 abnormal somite shape 8.05189952154418e-05 0.00105131527173247 0.979407854650197 0.821428571428571 5.2 5 2 premature aging 8.05189952154418e-05 0.00105131527173247 0.979407854650197 0.821428571428571 5.2 5 2 increased bone resorption 8.05189952154418e-05 0.00105131527173247 0.979407854650197 0.821428571428571 5.2 5 2 abnormal brainstem morphology 8.05189952154418e-05 0.00105131527173247 0.979407854650197 0.821428571428571 5.2 5 2 abnormal mitotic spindle morphology 8.05189952154418e-05 0.00105131527173247 0.979407854650197 0.821428571428571 5.2 5 2 subcutaneous edema 8.05189952154418e-05 0.00105131527173247 0.979407854650197 0.821428571428571 5.2 5 2 small liver 3.57534028148256e-11 2.11753784528282e-09 0.978315984132192 0.82051282051282 5.2 5 2 abnormal iris morphology 3.18668454857701e-06 6.52417927126363e-05 0.978315984132192 0.82051282051282 5.2 5 2 increased cardiomyocyte apoptosis 2.14627629559956e-05 0.000345557429469508 0.975536677359089 0.818181818181818 5.2 5 2 abnormal locomotor coordination 2.14627629559956e-05 0.000345557429469508 0.975536677359089 0.818181818181818 5.2 5 2 increased coping response 0.000559417109056601 0.00526105882335839 0.975536677359089 0.818181818181818 5.2 5 2 abnormal channel response 0.000559417109056601 0.00526105882335839 0.975536677359089 0.818181818181818 5.2 5 2 abnormal limb posture 0.000559417109056601 0.00526105882335839 0.975536677359089 0.818181818181818 5.2 5 2 increased mammary gland tumor incidence 0.000559417109056601 0.00526105882335839 0.975536677359089 0.818181818181818 5.2 5 2 premature suture closure 0.0164024950063289 0.0827610676029271 0.975536677359089 0.818181818181818 5.2 5 2 enlarged cranium 0.0164024950063289 0.0827610676029271 0.975536677359089 0.818181818181818 5.2 5 2 abnormal eye distance/ position 0.0164024950063289 0.0827610676029271 0.975536677359089 0.818181818181818 5.2 5 2 impaired myelopoiesis 0.0164024950063289 0.0827610676029271 0.975536677359089 0.818181818181818 5.2 5 2 secondary sex reversal 0.0164024950063289 0.0827610676029271 0.975536677359089 0.818181818181818 5.2 5 2 fused joints 0.0164024950063289 0.0827610676029271 0.975536677359089 0.818181818181818 5.2 5 2 loss of cortex neurons 0.0164024950063289 0.0827610676029271 0.975536677359089 0.818181818181818 5.2 5 2 abnormal radial glial cell morphology 0.0164024950063289 0.0827610676029271 0.975536677359089 0.818181818181818 5.2 5 2 abnormal coronal suture morphology 0.0164024950063289 0.0827610676029271 0.975536677359089 0.818181818181818 5.2 5 2 abnormal palatal shelf elevation 0.0164024950063289 0.0827610676029271 0.975536677359089 0.818181818181818 5.2 5 2 abnormal pulmonary alveolar sac morphology 0.0164024950063289 0.0827610676029271 0.975536677359089 0.818181818181818 5.2 5 2 decreased embryonic cilium length 0.0164024950063289 0.0827610676029271 0.975536677359089 0.818181818181818 5.2 5 2 intracranial hemorrhage 9.89439122046178e-09 3.59303622786842e-07 0.973730127956572 0.816666666666667 5.2 5 2 increased T cell derived lymphoma incidence 2.36422057418425e-07 6.32365449277777e-06 0.973324576049885 0.816326530612245 5.2 5 2 abnormal cell morphology 2.63422088858213e-15 2.73026019181168e-13 0.972684230934063 0.815789473684211 5.2 5 2 seizures 2.63422088858213e-15 2.73026019181168e-13 0.972684230934063 0.815789473684211 5.2 5 2 incomplete somite formation 5.7732039468272e-06 0.000110044787875346 0.972684230934063 0.815789473684211 5.2 5 2 decreased total retina thickness 5.7732039468272e-06 0.000110044787875346 0.972684230934063 0.815789473684211 5.2 5 2 increased neuron apoptosis 3.23924379010159e-11 1.94159492238017e-09 0.971522123131274 0.814814814814815 5.2 5 2 abnormal brain commissure morphology 0.00014629594841716 0.00171252316088322 0.971522123131274 0.814814814814815 5.2 5 2 abnormal eye muscle morphology 0.00014629594841716 0.00171252316088322 0.971522123131274 0.814814814814815 5.2 5 2 kidney cortex cysts 3.88115918270166e-05 0.000567904909821787 0.968762117099651 0.8125 5.2 5 2 pancreatic islet hyperplasia 3.88115918270166e-05 0.000567904909821787 0.968762117099651 0.8125 5.2 5 2 failure of tooth eruption 0.00399586573870673 0.0272694541153169 0.968762117099651 0.8125 5.2 5 2 poor circulation 0.00399586573870673 0.0272694541153169 0.968762117099651 0.8125 5.2 5 2 increased intestinal adenocarcinoma incidence 0.00399586573870673 0.0272694541153169 0.968762117099651 0.8125 5.2 5 2 impaired muscle relaxation 0.00399586573870673 0.0272694541153169 0.968762117099651 0.8125 5.2 5 2 small pancreas 0.00399586573870673 0.0272694541153169 0.968762117099651 0.8125 5.2 5 2 blepharitis 0.00399586573870673 0.0272694541153169 0.968762117099651 0.8125 5.2 5 2 decreased fibroblast apoptosis 0.00399586573870673 0.0272694541153169 0.968762117099651 0.8125 5.2 5 2 gliosis 8.79901003881757e-09 3.21875551052334e-07 0.965213537916136 0.80952380952381 5.2 5 2 abnormal pancreas morphology 2.80992689476937e-06 5.84911560731282e-05 0.965213537916136 0.80952380952381 5.2 5 2 liver degeneration 0.00101444604013988 0.00888556007909794 0.965213537916136 0.80952380952381 5.2 5 2 left pulmonary isomerism 0.00101444604013988 0.00888556007909794 0.965213537916136 0.80952380952381 5.2 5 2 pulmonary hypoplasia 7.63531130964672e-07 1.81749635241591e-05 0.964005510960045 0.808510638297872 5.2 5 2 abnormal fertility/fecundity 6.71397498689135e-10 3.12168463175556e-08 0.963657996356239 0.808219178082192 5.2 5 2 no spontaneous movement 0.000263861782257239 0.00278117026849526 0.963029796880127 0.807692307692308 5.2 5 2 decreased circulating glycerol level 0.000263861782257239 0.00278117026849526 0.963029796880127 0.807692307692308 5.2 5 2 increased thymocyte apoptosis 0.000263861782257239 0.00278117026849526 0.963029796880127 0.807692307692308 5.2 5 2 pale kidney 6.97352139273809e-05 0.000945320679260818 0.961550488436378 0.806451612903226 5.2 5 2 preaxial polydactyly 6.97352139273809e-05 0.000945320679260818 0.961550488436378 0.806451612903226 5.2 5 2 abnormal pharyngeal arch morphology 1.86389721581487e-05 0.000308069390321561 0.960482099004782 0.805555555555556 5.2 5 2 embryonic lethality between implantation and placentation, complete penetrance 1.36273825021811e-06 3.04018959409646e-05 0.959042095857849 0.804347826086957 5.2 5 2 abnormal dendritic spine morphology 3.71540046266449e-07 9.40539757125559e-06 0.958533859453048 0.803921568627451 5.2 5 2 abnormal maternal nurturing 2.79382607343241e-08 9.26618981021748e-07 0.957767338973678 0.80327868852459 5.2 5 2 abnormal embryonic tissue morphology 5.67344020291182e-18 8.55314091196555e-16 0.957102499782387 0.802721088435374 5.2 5 2 abnormal behavior 1.31844465789806e-32 4.68518726645918e-30 0.956431442670602 0.802158273381295 5.2 5 2 abnormal contextual conditioning behavior 1.80344273601369e-07 4.92974044597148e-06 0.953858084528887 0.8 5.2 5 2 abnormal hearing physiology 0.00182233833033569 0.0146444403063394 0.953858084528887 0.8 5.2 5 2 abnormal optic stalk morphology 0.00182233833033569 0.0146444403063394 0.953858084528887 0.8 5.2 5 2 abnormal sperm mitochondrial sheath morphology 0.00182233833033569 0.0146444403063394 0.953858084528887 0.8 5.2 5 2 abnormal neuron proliferation 0.00182233833033569 0.0146444403063394 0.953858084528887 0.8 5.2 5 2 absent ductus venosus valve 0.00182233833033569 0.0146444403063394 0.953858084528887 0.8 5.2 5 2 absent incisors 0.00722181494698476 0.0437086731888676 0.953858084528887 0.8 5.2 5 2 audiogenic seizures 0.00722181494698476 0.0437086731888676 0.953858084528887 0.8 5.2 5 2 abnormal seizure response to electrical stimulation 0.00722181494698476 0.0437086731888676 0.953858084528887 0.8 5.2 5 2 abnormal placenta size 0.00722181494698476 0.0437086731888676 0.953858084528887 0.8 5.2 5 2 abnormal olfactory nerve morphology 0.00722181494698476 0.0437086731888676 0.953858084528887 0.8 5.2 5 2 decreased thymocyte apoptosis 0.00722181494698476 0.0437086731888676 0.953858084528887 0.8 5.2 5 2 abnormal coronary vessel morphology 0.00722181494698476 0.0437086731888676 0.953858084528887 0.8 5.2 5 2 abnormal branching involved in lung morphogenesis 0.00722181494698476 0.0437086731888676 0.953858084528887 0.8 5.2 5 2 small petrosal ganglion 0.0299635148018308 0.127955782093655 0.953858084528887 0.8 5.2 5 2 fused cornea and lens 0.0299635148018308 0.127955782093655 0.953858084528887 0.8 5.2 5 2 abnormal optic nerve innervation 0.0299635148018308 0.127955782093655 0.953858084528887 0.8 5.2 5 2 absent trophoblast giant cells 0.0299635148018308 0.127955782093655 0.953858084528887 0.8 5.2 5 2 impaired social transmission of food preference 0.0299635148018308 0.127955782093655 0.953858084528887 0.8 5.2 5 2 primary sex reversal 0.0299635148018308 0.127955782093655 0.953858084528887 0.8 5.2 5 2 acrania 0.0299635148018308 0.127955782093655 0.953858084528887 0.8 5.2 5 2 aneurysm 0.0299635148018308 0.127955782093655 0.953858084528887 0.8 5.2 5 2 increased atrioventricular cushion size 0.0299635148018308 0.127955782093655 0.953858084528887 0.8 5.2 5 2 absent pharyngeal arches 0.0299635148018308 0.127955782093655 0.953858084528887 0.8 5.2 5 2 abnormal ear physiology 0.0299635148018308 0.127955782093655 0.953858084528887 0.8 5.2 5 2 abnormal reproductive system development 0.0299635148018308 0.127955782093655 0.953858084528887 0.8 5.2 5 2 abnormal gas homeostasis 0.0299635148018308 0.127955782093655 0.953858084528887 0.8 5.2 5 2 abnormal deltoid tuberosity morphology 0.0299635148018308 0.127955782093655 0.953858084528887 0.8 5.2 5 2 abnormal cochlear inner hair cell physiology 0.0299635148018308 0.127955782093655 0.953858084528887 0.8 5.2 5 2 abnormal corneal endothelium morphology 0.0299635148018308 0.127955782093655 0.953858084528887 0.8 5.2 5 2 abnormal developmental vascular remodeling 0.0299635148018308 0.127955782093655 0.953858084528887 0.8 5.2 5 2 impaired behavioral response to morphine 0.0299635148018308 0.127955782093655 0.953858084528887 0.8 5.2 5 2 increased serotonin level 0.0299635148018308 0.127955782093655 0.953858084528887 0.8 5.2 5 2 increased circulating fructosamine level 0.0299635148018308 0.127955782093655 0.953858084528887 0.8 5.2 5 2 abnormal inferior vena cava valve morphology 0.0299635148018308 0.127955782093655 0.953858084528887 0.8 5.2 5 2 thick aortic valve 0.0299635148018308 0.127955782093655 0.953858084528887 0.8 5.2 5 2 sinus bradycardia 0.0299635148018308 0.127955782093655 0.953858084528887 0.8 5.2 5 2 abnormal circadian temperature homeostasis 0.0299635148018308 0.127955782093655 0.953858084528887 0.8 5.2 5 2 abnormal cell cycle 3.72528734392808e-14 3.19539733380038e-12 0.953858084528887 0.8 5.2 5 2 abnormal lung development 7.99330883725081e-11 4.32246863753509e-09 0.953858084528887 0.8 5.2 5 2 embryonic lethality between somite formation and embryo turning, complete penetrance 3.76109188052772e-09 1.47334111067917e-07 0.953858084528887 0.8 5.2 5 2 holoprosencephaly 3.31950542548809e-05 0.00049647191364253 0.953858084528887 0.8 5.2 5 2 abnormal hippocampus pyramidal cell morphology 3.31950542548809e-05 0.00049647191364253 0.953858084528887 0.8 5.2 5 2 abnormal eye morphology 1.11801210361912e-16 1.39052755387628e-14 0.952142512434411 0.798561151079137 5.2 5 2 abnormal motor coordination/ balance 3.03099017802742e-12 2.25062330383379e-10 0.951449351992198 0.797979797979798 5.2 5 2 impaired coordination 3.41688433376165e-39 1.69989995604642e-36 0.951101269255682 0.797687861271676 5.2 5 2 decreased exploration in new environment 1.40966898742459e-10 7.30531584628888e-09 0.951019221182075 0.797619047619048 5.2 5 2 kidney cysts 1.83464800120647e-09 7.60614483833516e-08 0.950635591000073 0.797297297297297 5.2 5 2 neurodegeneration 3.18413182428902e-07 8.20780094602998e-06 0.94944207487829 0.796296296296296 5.2 5 2 abnormal neuronal precursor proliferation 3.18413182428902e-07 8.20780094602998e-06 0.94944207487829 0.796296296296296 5.2 5 2 embryonic lethality between implantation and somite formation, complete penetrance 7.29413993787801e-28 2.13460859946724e-25 0.948991461648638 0.795918367346939 5.2 5 2 abnormal heart looping 1.57959666150466e-05 0.000267989033478205 0.947743609628061 0.794871794871795 5.2 5 2 preweaning lethality, incomplete penetrance 2.97935914743491e-45 1.85278896981108e-42 0.947444613300392 0.794621026894866 5.2 5 2 lordosis 0.000220450911785945 0.00237390321674259 0.945635170007087 0.793103448275862 5.2 5 2 increased mortality induced by gamma-irradiation 0.000220450911785945 0.00237390321674259 0.945635170007087 0.793103448275862 5.2 5 2 blood in lymph vessels 0.000220450911785945 0.00237390321674259 0.945635170007087 0.793103448275862 5.2 5 2 increased susceptibility to pharmacologically induced seizures 1.63669397858367e-11 1.01781906793172e-09 0.943922062815045 0.791666666666667 5.2 5 2 abnormal body weight 0.000837631639808393 0.00755370051214882 0.943922062815045 0.791666666666667 5.2 5 2 blindness 0.000837631639808393 0.00755370051214882 0.943922062815045 0.791666666666667 5.2 5 2 abnormal spatial learning 1.56420235829757e-18 2.43184585391575e-16 0.943617276872902 0.791411042944785 5.2 5 2 reduced fertility 5.19143879026623e-16 5.86986545035784e-14 0.943564651962029 0.79136690647482 5.2 5 2 abnormal vasculogenesis 7.51799432143218e-06 0.000139040973045075 0.94276671145297 0.790697674418605 5.2 5 2 abnormal frontal bone morphology 2.77643549294278e-05 0.000426319956092294 0.94130732025877 0.789473684210526 5.2 5 2 abnormal reproductive system physiology 2.77643549294278e-05 0.000426319956092294 0.94130732025877 0.789473684210526 5.2 5 2 abnormal cochlear inner hair cell morphology 0.00323980544757735 0.0228949319626383 0.94130732025877 0.789473684210526 5.2 5 2 abnormal blastocyst morphology 0.00323980544757735 0.0228949319626383 0.94130732025877 0.789473684210526 5.2 5 2 right-sided stomach 0.00323980544757735 0.0228949319626383 0.94130732025877 0.789473684210526 5.2 5 2 distended pericardium 9.79393156560401e-07 2.24538292805898e-05 0.940100516002028 0.788461538461538 5.2 5 2 decreased brown adipose tissue amount 0.000103250099062238 0.00126519517939565 0.939405689308753 0.787878787878788 5.2 5 2 abnormal neuron morphology 1.38745230256631e-11 8.84945539136846e-10 0.939405689308752 0.787878787878788 5.2 5 2 increased cellular sensitivity to gamma-irradiation 3.57980459145584e-06 7.21033515890397e-05 0.93863694488215 0.787234042553192 5.2 5 2 abnormal nervous system electrophysiology 6.39916714046131e-10 3.00338269092406e-08 0.936824904448014 0.785714285714286 5.2 5 2 rib bifurcation 0.000387478110156792 0.00382746174872075 0.936824904448014 0.785714285714286 5.2 5 2 midline facial cleft 0.0128811934222353 0.0670334071920718 0.936824904448014 0.785714285714286 5.2 5 2 abnormal kidney blood vessel morphology 0.0128811934222353 0.0670334071920718 0.936824904448014 0.785714285714286 5.2 5 2 translucent skin 0.0128811934222353 0.0670334071920718 0.936824904448014 0.785714285714286 5.2 5 2 abnormal placing response 0.0128811934222353 0.0670334071920718 0.936824904448014 0.785714285714286 5.2 5 2 increased hemangioma incidence 0.0128811934222353 0.0670334071920718 0.936824904448014 0.785714285714286 5.2 5 2 abnormal ventral body wall morphology 0.0128811934222353 0.0670334071920718 0.936824904448014 0.785714285714286 5.2 5 2 failure of zygotic cell division 0.0128811934222353 0.0670334071920718 0.936824904448014 0.785714285714286 5.2 5 2 abnormal vascular endothelial cell migration 0.0128811934222353 0.0670334071920718 0.936824904448014 0.785714285714286 5.2 5 2 abnormal sagittal suture morphology 0.0128811934222353 0.0670334071920718 0.936824904448014 0.785714285714286 5.2 5 2 split sternum 0.0128811934222353 0.0670334071920718 0.936824904448014 0.785714285714286 5.2 5 2 lysosomal protein accumulation 0.0128811934222353 0.0670334071920718 0.936824904448014 0.785714285714286 5.2 5 2 premature hair loss 0.0128811934222353 0.0670334071920718 0.936824904448014 0.785714285714286 5.2 5 2 increased circulating growth hormone level 0.0128811934222353 0.0670334071920718 0.936824904448014 0.785714285714286 5.2 5 2 abnormal viscerocranium morphology 0.0128811934222353 0.0670334071920718 0.936824904448014 0.785714285714286 5.2 5 2 sternebra fusion 0.0128811934222353 0.0670334071920718 0.936824904448014 0.785714285714286 5.2 5 2 decreased cell proliferation 6.36090464318455e-20 1.1301964499944e-17 0.934523123356004 0.783783783783784 5.2 5 2 absent mesoderm 2.24306647854353e-07 6.09795395123172e-06 0.933986041101202 0.783333333333333 5.2 5 2 abnormal forelimb morphology 6.22799110087567e-06 0.000117072556967638 0.933122039213042 0.782608695652174 5.2 5 2 abnormal allantois morphology 6.22799110087567e-06 0.000117072556967638 0.933122039213042 0.782608695652174 5.2 5 2 abnormal Wolffian duct morphology 0.00147225061817462 0.0120705006743786 0.933122039213042 0.782608695652174 5.2 5 2 abnormal corneal stroma morphology 0.00147225061817462 0.0120705006743786 0.933122039213042 0.782608695652174 5.2 5 2 abnormal chondrocyte physiology 0.00147225061817462 0.0120705006743786 0.933122039213042 0.782608695652174 5.2 5 2 abnormal basicranium morphology 0.00147225061817462 0.0120705006743786 0.933122039213042 0.782608695652174 5.2 5 2 abnormal hematopoietic stem cell physiology 0.00147225061817462 0.0120705006743786 0.933122039213042 0.782608695652174 5.2 5 2 decreased embryo size 7.2034297858049e-49 5.97284386406323e-46 0.932905134973336 0.782426778242678 5.2 5 2 lethality throughout fetal growth and development, incomplete penetrance 3.90738524949681e-19 6.27072310201504e-17 0.932542820070141 0.782122905027933 5.2 5 2 increased embryonic tissue cell apoptosis 3.979742751053e-09 1.54681407706943e-07 0.932457422375995 0.782051282051282 5.2 5 2 abnormal embryo turning 8.13160105727576e-07 1.8904072551377e-05 0.932179491698685 0.781818181818182 5.2 5 2 abnormal learning/memory/conditioning 8.13160105727576e-07 1.8904072551377e-05 0.932179491698685 0.781818181818182 5.2 5 2 hyperactivity 5.03468882910512e-38 2.0872980770665e-35 0.932004193104371 0.78167115902965 5.2 5 2 scoliosis 0.000180176721428681 0.0019744035002372 0.931502035672741 0.78125 5.2 5 2 failure of primitive streak formation 0.000180176721428681 0.0019744035002372 0.931502035672741 0.78125 5.2 5 2 abnormal long term potentiation 0.000180176721428681 0.0019744035002372 0.931502035672741 0.78125 5.2 5 2 abnormal auditory brainstem response waveform shape 0.000180176721428681 0.0019744035002372 0.931502035672741 0.78125 5.2 5 2 increased fibroblast apoptosis 0.000180176721428681 0.0019744035002372 0.931502035672741 0.78125 5.2 5 2 astrocytosis 1.42976597118069e-08 4.97418580882793e-07 0.9309916235984 0.780821917808219 5.2 5 2 abnormal mammary gland development 2.28343102041485e-05 0.000362941512030795 0.930593253198914 0.780487804878049 5.2 5 2 thick ventricular wall 2.28343102041485e-05 0.000362941512030795 0.930593253198914 0.780487804878049 5.2 5 2 abnormal cell differentiation 2.28343102041485e-05 0.000362941512030795 0.930593253198914 0.780487804878049 5.2 5 2 lethality at weaning, incomplete penetrance 2.28343102041485e-05 0.000362941512030795 0.930593253198914 0.780487804878049 5.2 5 2 abnormal motor capabilities/coordination/movement 2.44969707861564e-14 2.17629338680586e-12 0.930372942296168 0.78030303030303 5.2 5 2 increased B cell derived lymphoma incidence 2.95555020931704e-06 6.10118767276028e-05 0.930011632415665 0.78 5.2 5 2 abnormal axon extension 2.95555020931704e-06 6.10118767276028e-05 0.930011632415665 0.78 5.2 5 2 abnormal embryo development 1.18626227779497e-14 1.13493362154423e-12 0.929310266177041 0.779411764705882 5.2 5 2 abnormal heart development 1.0692195563994e-16 1.36394033156077e-14 0.928200509470357 0.778481012658228 5.2 5 2 impaired limb coordination 1.40427880529865e-06 3.11887815016107e-05 0.927362026625307 0.777777777777778 5.2 5 2 abnormal ectoderm development 1.07756913804902e-05 0.000192838361935032 0.927362026625307 0.777777777777778 5.2 5 2 abnormal trigeminal nerve morphology 0.000675342200697519 0.00617615339792308 0.927362026625307 0.777777777777778 5.2 5 2 decreased circulating fructosamine level 0.000675342200697519 0.00617615339792308 0.927362026625307 0.777777777777778 5.2 5 2 acidosis 0.00569397695690934 0.03540941920078 0.927362026625307 0.777777777777778 5.2 5 2 absent inner cell mass 0.00569397695690934 0.03540941920078 0.927362026625307 0.777777777777778 5.2 5 2 increased gastrointestinal tumor incidence 0.00569397695690934 0.03540941920078 0.927362026625307 0.777777777777778 5.2 5 2 distorted hair follicle pattern 0.0537513689607317 0.189440864271498 0.927362026625307 0.777777777777778 5.2 5 2 small nodose ganglion 0.0537513689607317 0.189440864271498 0.927362026625307 0.777777777777778 5.2 5 2 abnormal vagina epithelium morphology 0.0537513689607317 0.189440864271498 0.927362026625307 0.777777777777778 5.2 5 2 abnormal vomeronasal organ morphology 0.0537513689607317 0.189440864271498 0.927362026625307 0.777777777777778 5.2 5 2 polycythemia 0.0537513689607317 0.189440864271498 0.927362026625307 0.777777777777778 5.2 5 2 genetic imprinting 0.0537513689607317 0.189440864271498 0.927362026625307 0.777777777777778 5.2 5 2 biliary cyst 0.0537513689607317 0.189440864271498 0.927362026625307 0.777777777777778 5.2 5 2 premature bone ossification 0.0537513689607317 0.189440864271498 0.927362026625307 0.777777777777778 5.2 5 2 decreased fear-related response 0.0537513689607317 0.189440864271498 0.927362026625307 0.777777777777778 5.2 5 2 abnormal thymus physiology 0.0537513689607317 0.189440864271498 0.927362026625307 0.777777777777778 5.2 5 2 impaired febrile response 0.0537513689607317 0.189440864271498 0.927362026625307 0.777777777777778 5.2 5 2 decreased vestibular hair cell number 0.0537513689607317 0.189440864271498 0.927362026625307 0.777777777777778 5.2 5 2 short frontal bone 0.0537513689607317 0.189440864271498 0.927362026625307 0.777777777777778 5.2 5 2 abnormal CNS synapse formation 0.0537513689607317 0.189440864271498 0.927362026625307 0.777777777777778 5.2 5 2 abnormal inguinal fat pad morphology 0.0537513689607317 0.189440864271498 0.927362026625307 0.777777777777778 5.2 5 2 enhanced conditioned place preference behavior 0.0537513689607317 0.189440864271498 0.927362026625307 0.777777777777778 5.2 5 2 abnormal optic chiasm morphology 0.0537513689607317 0.189440864271498 0.927362026625307 0.777777777777778 5.2 5 2 abnormal retinal development 0.0537513689607317 0.189440864271498 0.927362026625307 0.777777777777778 5.2 5 2 multiflagellated sperm 0.0537513689607317 0.189440864271498 0.927362026625307 0.777777777777778 5.2 5 2 eye opacity 0.0537513689607317 0.189440864271498 0.927362026625307 0.777777777777778 5.2 5 2 abnormal cerebellar layer morphology 0.0537513689607317 0.189440864271498 0.927362026625307 0.777777777777778 5.2 5 2 axonal spheroids 0.0537513689607317 0.189440864271498 0.927362026625307 0.777777777777778 5.2 5 2 abnormal telomere morphology 0.0537513689607317 0.189440864271498 0.927362026625307 0.777777777777778 5.2 5 2 shortened ST segment 0.0537513689607317 0.189440864271498 0.927362026625307 0.777777777777778 5.2 5 2 fusion of atlas and occipital bones 0.0537513689607317 0.189440864271498 0.927362026625307 0.777777777777778 5.2 5 2 abnormal pulmonary alveolar system morphology 0.0537513689607317 0.189440864271498 0.927362026625307 0.777777777777778 5.2 5 2 decreased bone trabecular spacing 0.0537513689607317 0.189440864271498 0.927362026625307 0.777777777777778 5.2 5 2 increased myeloid cell number 0.0537513689607317 0.189440864271498 0.927362026625307 0.777777777777778 5.2 5 2 abnormal infrahyoid muscle connection 0.0537513689607317 0.189440864271498 0.927362026625307 0.777777777777778 5.2 5 2 increased endoplasmic reticulum stress 0.0537513689607317 0.189440864271498 0.927362026625307 0.777777777777778 5.2 5 2 decreased startle reflex 1.10080587903613e-12 8.4253988433919e-11 0.927362026625307 0.777777777777778 5.2 5 2 embryonic growth arrest 2.2334950630091e-23 4.62984914102928e-21 0.926783510077194 0.777292576419214 5.2 5 2 abnormal craniofacial morphology 2.88629775743254e-11 1.75113796868621e-09 0.926075810222221 0.776699029126214 5.2 5 2 rib fusion 8.84665709787781e-08 2.57380813227732e-06 0.925384708871308 0.776119402985075 5.2 5 2 preweaning lethality, complete penetrance 4.80114806184194e-72 7.96190386922122e-69 0.924855642769563 0.775675675675676 5.2 5 2 abnormal skeletal muscle fiber morphology 4.22843023112394e-08 1.3147775249901e-06 0.923630187483958 0.774647887323944 5.2 5 2 osteopetrosis 0.000312013143619393 0.00322046761308398 0.923088468898923 0.774193548387097 5.2 5 2 abnormal vitelline vasculature morphology 3.22940877734406e-12 2.36269245107157e-10 0.922754016555119 0.773913043478261 5.2 5 2 omphalocele 1.85369231335947e-05 0.000307403975298779 0.921340195283584 0.772727272727273 5.2 5 2 embryonic lethality, incomplete penetrance 1.85369231335947e-05 0.000307403975298779 0.921340195283584 0.772727272727273 5.2 5 2 abnormal oogenesis 0.00256154440582305 0.0186077778899036 0.921340195283584 0.772727272727273 5.2 5 2 increased skin papilloma incidence 0.00256154440582305 0.0186077778899036 0.921340195283584 0.772727272727273 5.2 5 2 abnormal lysosome physiology 0.00256154440582305 0.0186077778899036 0.921340195283584 0.772727272727273 5.2 5 2 cleft upper lip 0.00256154440582305 0.0186077778899036 0.921340195283584 0.772727272727273 5.2 5 2 increased circulating creatine kinase level 0.00256154440582305 0.0186077778899036 0.921340195283584 0.772727272727273 5.2 5 2 embryonic lethality before implantation, incomplete penetrance 0.00256154440582305 0.0186077778899036 0.921340195283584 0.772727272727273 5.2 5 2 abnormal neural tube morphology 2.13870953203021e-16 2.53335236234531e-14 0.920002010540979 0.771604938271605 5.2 5 2 abnormal embryonic epiblast morphology 0.000144965542480203 0.00170517090170846 0.919791724367141 0.771428571428571 5.2 5 2 abnormal neural tube closure 4.63191741319644e-09 1.77259916389633e-07 0.919381286292903 0.771084337349398 5.2 5 2 increased bone mineral content 1.95116112056862e-11 1.19839834257146e-09 0.918854118124157 0.770642201834862 5.2 5 2 pale liver 3.45138047662345e-08 1.12226260596089e-06 0.918410655711935 0.77027027027027 5.2 5 2 abnormal Schwann cell morphology 0.00116643478758198 0.0100426241641873 0.91717123512393 0.769230769230769 5.2 5 2 absent myocardial trabeculae 0.022631972951895 0.102079841736788 0.91717123512393 0.769230769230769 5.2 5 2 tight skin 0.022631972951895 0.102079841736788 0.91717123512393 0.769230769230769 5.2 5 2 abnormal grip strength 0.022631972951895 0.102079841736788 0.91717123512393 0.769230769230769 5.2 5 2 abnormal lung interstitium morphology 0.022631972951895 0.102079841736788 0.91717123512393 0.769230769230769 5.2 5 2 dystrophic cardiac calcinosis 0.022631972951895 0.102079841736788 0.91717123512393 0.769230769230769 5.2 5 2 abnormal tail bud morphology 0.022631972951895 0.102079841736788 0.91717123512393 0.769230769230769 5.2 5 2 small interparietal bone 0.022631972951895 0.102079841736788 0.91717123512393 0.769230769230769 5.2 5 2 increased cochlear inner hair cell number 0.022631972951895 0.102079841736788 0.91717123512393 0.769230769230769 5.2 5 2 abnormal exocrine pancreas morphology 0.022631972951895 0.102079841736788 0.91717123512393 0.769230769230769 5.2 5 2 decreased cardiac stroke volume 0.022631972951895 0.102079841736788 0.91717123512393 0.769230769230769 5.2 5 2 increased grip strength 1.06285828749902e-09 4.5194187865877e-08 0.91717123512393 0.769230769230769 5.2 5 2 failure of heart looping 6.76589826440315e-05 0.000924734721577079 0.91717123512393 0.769230769230769 5.2 5 2 abnormal gait 4.27047525736158e-29 1.32785090033587e-26 0.914499862594443 0.766990291262136 5.2 5 2 abnormal response to new environment 0.000535905040323925 0.00508802972444948 0.914113997673517 0.766666666666667 5.2 5 2 neuron degeneration 1.48947833135225e-05 0.000256406736971538 0.913268378804254 0.765957446808511 5.2 5 2 abnormal nervous system physiology 1.29474333149878e-11 8.36538710935902e-10 0.912385993897196 0.765217391304348 5.2 5 2 abnormal extraembryonic tissue morphology 1.98196702452408e-10 9.86028594700732e-09 0.911776110211436 0.764705882352941 5.2 5 2 failure of chorioallantoic fusion 7.01790374485493e-06 0.000130764311350761 0.911776110211436 0.764705882352941 5.2 5 2 abnormal vision 0.000247899489147338 0.00264005759091787 0.911776110211436 0.764705882352941 5.2 5 2 abnormal adipose tissue morphology 0.00987997882805376 0.0548373294270455 0.911776110211436 0.764705882352941 5.2 5 2 abnormal bone marrow cavity morphology 0.00987997882805376 0.0548373294270455 0.911776110211436 0.764705882352941 5.2 5 2 increased aggression towards mice 0.00987997882805376 0.0548373294270455 0.911776110211436 0.764705882352941 5.2 5 2 hyperlipidemia 0.00987997882805376 0.0548373294270455 0.911776110211436 0.764705882352941 5.2 5 2 abnormal heart rate 0.00987997882805376 0.0548373294270455 0.911776110211436 0.764705882352941 5.2 5 2 abnormal cranial suture morphology 0.00987997882805376 0.0548373294270455 0.911776110211436 0.764705882352941 5.2 5 2 abnormal glutamate-mediated receptor currents 0.00987997882805376 0.0548373294270455 0.911776110211436 0.764705882352941 5.2 5 2 abnormal ectoplacental cone morphology 0.00987997882805376 0.0548373294270455 0.911776110211436 0.764705882352941 5.2 5 2 abnormal tarsal bone morphology 0.00987997882805376 0.0548373294270455 0.911776110211436 0.764705882352941 5.2 5 2 increased circulating magnesium level 0.00987997882805376 0.0548373294270455 0.911776110211436 0.764705882352941 5.2 5 2 delayed heart development 0.00987997882805376 0.0548373294270455 0.911776110211436 0.764705882352941 5.2 5 2 anophthalmia 3.05110397237732e-09 1.21433938100617e-07 0.910988058257926 0.764044943820225 5.2 5 2 decreased neuron apoptosis 0.000115292315741151 0.00139218269614618 0.909930409583478 0.763157894736842 5.2 5 2 abnormal eye pigmentation 0.00440759365896226 0.0289666822369052 0.908436270979893 0.761904761904762 5.2 5 2 abnormal anxiety-related response 0.00440759365896226 0.0289666822369052 0.908436270979893 0.761904761904762 5.2 5 2 trunk curl 0.00440759365896226 0.0289666822369052 0.908436270979893 0.761904761904762 5.2 5 2 abnormal embryonic/fetal subventricular zone morphology 0.00440759365896226 0.0289666822369052 0.908436270979893 0.761904761904762 5.2 5 2 complete atrioventricular septal defect 0.00440759365896226 0.0289666822369052 0.908436270979893 0.761904761904762 5.2 5 2 decreased vocalization 0.00440759365896226 0.0289666822369052 0.908436270979893 0.761904761904762 5.2 5 2 abnormal erythropoiesis 1.60137830723485e-10 8.04733038231656e-09 0.908436270979892 0.761904761904762 5.2 5 2 abnormal locomotor behavior 2.45817452944212e-09 9.94261649103623e-08 0.907201982568235 0.760869565217391 5.2 5 2 embryonic lethality before implantation, complete penetrance 4.05833493144101e-12 2.88431661198843e-10 0.906165180302443 0.76 5.2 5 2 decreased oocyte number 1.18703055645133e-05 0.000210909893512334 0.906165180302443 0.76 5.2 5 2 abnormal primitive streak morphology 0.00199499694123947 0.0153877671049091 0.906165180302443 0.76 5.2 5 2 abnormal vertebrae development 0.00199499694123947 0.0153877671049091 0.906165180302443 0.76 5.2 5 2 increased liver glycogen level 0.00199499694123947 0.0153877671049091 0.906165180302443 0.76 5.2 5 2 abnormal somite development 3.79964613305532e-08 1.21956383948066e-06 0.905561472654007 0.759493670886076 5.2 5 2 prenatal lethality, complete penetrance 5.20698525530493e-25 1.23355960214962e-22 0.904964279836309 0.758992805755396 5.2 5 2 pericardial effusion 1.25117330486678e-06 2.81655529036753e-05 0.903857459130195 0.758064516129032 5.2 5 2 decreased grip strength 6.94304601933146e-20 1.19109151538531e-17 0.903769646300201 0.757990867579909 5.2 5 2 impaired righting response 1.97211699862661e-09 8.10849757699786e-08 0.903655027448419 0.757894736842105 5.2 5 2 abnormal QRS complex 0.000420572416323817 0.00408403321792614 0.903274701258416 0.757575757575758 5.2 5 2 domed cranium 2.81621500531653e-07 7.41305272563478e-06 0.902758544286268 0.757142857142857 5.2 5 2 abnormal vocalization 0.000195042124300923 0.00212327039036562 0.902298188067866 0.756756756756757 5.2 5 2 abnormal breathing pattern 0.000195042124300923 0.00212327039036562 0.902298188067866 0.756756756756757 5.2 5 2 increased bone trabecula number 9.08927550276162e-05 0.00115061439252517 0.901512214036448 0.75609756097561 5.2 5 2 oxidative stress 6.9066776693156e-09 2.58351288758234e-07 0.900865968721727 0.755555555555556 5.2 5 2 abnormal myocardial trabeculae morphology 4.2526184915918e-05 0.000618619210399685 0.900865968721727 0.755555555555556 5.2 5 2 embryonic lethality during organogenesis, complete penetrance 7.33958990093864e-48 5.21635139388139e-45 0.900629396776159 0.755357142857143 5.2 5 2 incomplete embryo turning 4.43393204126715e-06 8.75349678781908e-05 0.89947143935838 0.754385964912281 5.2 5 2 perinatal lethality, incomplete penetrance 9.93732008106285e-20 1.64793891344292e-17 0.896879836116763 0.752212389380531 5.2 5 2 abnormal embryo size 1.37528239906829e-10 7.20213677406814e-09 0.896879836116763 0.752212389380531 5.2 5 2 abnormal neuromuscular synapse morphology 3.7243483849997e-07 9.40539757125559e-06 0.894241954245832 0.75 5.2 5 2 hydrops fetalis 3.7243483849997e-07 9.40539757125559e-06 0.894241954245832 0.75 5.2 5 2 decreased mean corpuscular hemoglobin 7.84415779337742e-07 1.84078702934211e-05 0.894241954245832 0.75 5.2 5 2 abnormal kidney development 3.49534215125064e-06 7.0721913604138e-05 0.894241954245832 0.75 5.2 5 2 eyelids open at birth 1.56928079660535e-05 0.000267890154227676 0.894241954245832 0.75 5.2 5 2 abnormal digestive system morphology 0.0033761075532733 0.0236565282782179 0.894241954245832 0.75 5.2 5 2 abnormal nursing 0.0033761075532733 0.0236565282782179 0.894241954245832 0.75 5.2 5 2 abnormal cardiac muscle contractility 0.0033761075532733 0.0236565282782179 0.894241954245832 0.75 5.2 5 2 abnormal retinal ganglion layer morphology 0.0033761075532733 0.0236565282782179 0.894241954245832 0.75 5.2 5 2 abnormal truncus arteriosus septation 0.0033761075532733 0.0236565282782179 0.894241954245832 0.75 5.2 5 2 abnormal circulating enzyme level 0.00749220679930233 0.0451802773654898 0.894241954245832 0.75 5.2 5 2 increased mammary adenocarcinoma incidence 0.00749220679930233 0.0451802773654898 0.894241954245832 0.75 5.2 5 2 decreased myocardial infarction size 0.00749220679930233 0.0451802773654898 0.894241954245832 0.75 5.2 5 2 abnormal thymus involution 0.0390789716153928 0.154177544636462 0.894241954245832 0.75 5.2 5 2 abnormal embryonic growth/weight/body size 0.0390789716153928 0.154177544636462 0.894241954245832 0.75 5.2 5 2 increased growth rate 0.0390789716153928 0.154177544636462 0.894241954245832 0.75 5.2 5 2 loss of dopaminergic neurons 0.0390789716153928 0.154177544636462 0.894241954245832 0.75 5.2 5 2 abnormal vascular endothelial cell development 0.0390789716153928 0.154177544636462 0.894241954245832 0.75 5.2 5 2 increased osteosarcoma incidence 0.0390789716153928 0.154177544636462 0.894241954245832 0.75 5.2 5 2 abnormal nucleotide metabolism 0.0390789716153928 0.154177544636462 0.894241954245832 0.75 5.2 5 2 decreased left ventricle systolic pressure 0.0390789716153928 0.154177544636462 0.894241954245832 0.75 5.2 5 2 absent cochlear hair cells 0.0390789716153928 0.154177544636462 0.894241954245832 0.75 5.2 5 2 abnormal amacrine cell morphology 0.0390789716153928 0.154177544636462 0.894241954245832 0.75 5.2 5 2 abnormal fatty acid level 0.0390789716153928 0.154177544636462 0.894241954245832 0.75 5.2 5 2 decreased renal glomerular filtration rate 0.0390789716153928 0.154177544636462 0.894241954245832 0.75 5.2 5 2 abnormal thymus corticomedullary boundary morphology 0.0390789716153928 0.154177544636462 0.894241954245832 0.75 5.2 5 2 decreased keratinocyte proliferation 0.0390789716153928 0.154177544636462 0.894241954245832 0.75 5.2 5 2 hydrometra 0.0390789716153928 0.154177544636462 0.894241954245832 0.75 5.2 5 2 decreased red blood cell distribution width 0.0390789716153928 0.154177544636462 0.894241954245832 0.75 5.2 5 2 decreased mammary gland epithelial cell proliferation 0.0390789716153928 0.154177544636462 0.894241954245832 0.75 5.2 5 2 persistent right dorsal aorta 0.0390789716153928 0.154177544636462 0.894241954245832 0.75 5.2 5 2 abnormal pulmonary valve cusp morphology 0.0390789716153928 0.154177544636462 0.894241954245832 0.75 5.2 5 2 decreased caudal vertebrae number 1.65448961107297e-06 3.62602899343084e-05 0.894241954245832 0.75 5.2 5 2 abnormal osteoclast physiology 1.65448961107297e-06 3.62602899343084e-05 0.894241954245832 0.75 5.2 5 2 decreased blood urea nitrogen level 7.1173163609284e-05 0.00095441102144525 0.894241954245832 0.75 5.2 5 2 lethality, incomplete penetrance 7.1173163609284e-05 0.00095441102144525 0.894241954245832 0.75 5.2 5 2 abnormal spongiotrophoblast layer morphology 0.000707522410191525 0.00642321896113656 0.894241954245832 0.75 5.2 5 2 straub tail 0.00153893447231969 0.0125717553362733 0.894241954245832 0.75 5.2 5 2 abnormal hormone level 0.00153893447231969 0.0125717553362733 0.894241954245832 0.75 5.2 5 2 reduced male mating frequency 0.0168996625718188 0.0844134751955808 0.894241954245832 0.75 5.2 5 2 abnormal olfaction 0.0168996625718188 0.0844134751955808 0.894241954245832 0.75 5.2 5 2 abnormal epicardium morphology 0.0168996625718188 0.0844134751955808 0.894241954245832 0.75 5.2 5 2 small epididymis 0.0168996625718188 0.0844134751955808 0.894241954245832 0.75 5.2 5 2 abnormal amnion morphology 0.0168996625718188 0.0844134751955808 0.894241954245832 0.75 5.2 5 2 loose skin 0.0168996625718188 0.0844134751955808 0.894241954245832 0.75 5.2 5 2 impaired somite development 0.0168996625718188 0.0844134751955808 0.894241954245832 0.75 5.2 5 2 abnormal pulmonary alveolus wall morphology 0.0168996625718188 0.0844134751955808 0.894241954245832 0.75 5.2 5 2 decreased midbrain size 0.0168996625718188 0.0844134751955808 0.894241954245832 0.75 5.2 5 2 abnormal exoccipital bone morphology 0.0943179545754335 0.267024827071749 0.894241954245832 0.75 5.2 5 2 absent mammary gland 0.0943179545754335 0.267024827071749 0.894241954245832 0.75 5.2 5 2 enlarged pituitary gland 0.0943179545754335 0.267024827071749 0.894241954245832 0.75 5.2 5 2 increased sensitivity to skin irradiation 0.0943179545754335 0.267024827071749 0.894241954245832 0.75 5.2 5 2 dermal cysts 0.0943179545754335 0.267024827071749 0.894241954245832 0.75 5.2 5 2 abnormal pupil morphology 0.0943179545754335 0.267024827071749 0.894241954245832 0.75 5.2 5 2 unidirectional circling 0.0943179545754335 0.267024827071749 0.894241954245832 0.75 5.2 5 2 abnormal atrial thrombosis 0.0943179545754335 0.267024827071749 0.894241954245832 0.75 5.2 5 2 preneoplasia 0.0943179545754335 0.267024827071749 0.894241954245832 0.75 5.2 5 2 abnormal hepatobiliary system morphology 0.0943179545754335 0.267024827071749 0.894241954245832 0.75 5.2 5 2 abnormal pulmonary circulation 0.0943179545754335 0.267024827071749 0.894241954245832 0.75 5.2 5 2 short ureter 0.0943179545754335 0.267024827071749 0.894241954245832 0.75 5.2 5 2 altered response to CNS ischemic injury 0.0943179545754335 0.267024827071749 0.894241954245832 0.75 5.2 5 2 abnormal muscle precursor cell migration 0.0943179545754335 0.267024827071749 0.894241954245832 0.75 5.2 5 2 hypospadia 0.0943179545754335 0.267024827071749 0.894241954245832 0.75 5.2 5 2 early eyelid opening 0.0943179545754335 0.267024827071749 0.894241954245832 0.75 5.2 5 2 decreased susceptibility to age related obesity 0.0943179545754335 0.267024827071749 0.894241954245832 0.75 5.2 5 2 liver failure 0.0943179545754335 0.267024827071749 0.894241954245832 0.75 5.2 5 2 abnormal ovary development 0.0943179545754335 0.267024827071749 0.894241954245832 0.75 5.2 5 2 abnormal eyelid aperture 0.0943179545754335 0.267024827071749 0.894241954245832 0.75 5.2 5 2 abnormal lateral ganglionic eminence morphology 0.0943179545754335 0.267024827071749 0.894241954245832 0.75 5.2 5 2 long femur 0.0943179545754335 0.267024827071749 0.894241954245832 0.75 5.2 5 2 bowed fibula 0.0943179545754335 0.267024827071749 0.894241954245832 0.75 5.2 5 2 abnormal NK cell morphology 0.0943179545754335 0.267024827071749 0.894241954245832 0.75 5.2 5 2 increased circulating prolactin level 0.0943179545754335 0.267024827071749 0.894241954245832 0.75 5.2 5 2 abnormal vertebral body development 0.0943179545754335 0.267024827071749 0.894241954245832 0.75 5.2 5 2 abnormal ilium morphology 0.0943179545754335 0.267024827071749 0.894241954245832 0.75 5.2 5 2 abnormal mast cell differentiation 0.0943179545754335 0.267024827071749 0.894241954245832 0.75 5.2 5 2 stomach epithelial hyperplasia 0.0943179545754335 0.267024827071749 0.894241954245832 0.75 5.2 5 2 abnormal epidermal lamellar body morphology 0.0943179545754335 0.267024827071749 0.894241954245832 0.75 5.2 5 2 abnormal base-excision repair 0.0943179545754335 0.267024827071749 0.894241954245832 0.75 5.2 5 2 abnormal frontonasal prominence morphology 0.0943179545754335 0.267024827071749 0.894241954245832 0.75 5.2 5 2 abnormal cerebellum deep nucleus morphology 0.0943179545754335 0.267024827071749 0.894241954245832 0.75 5.2 5 2 abnormal brain ependyma morphology 0.0943179545754335 0.267024827071749 0.894241954245832 0.75 5.2 5 2 heart right ventricle hypoplasia 0.0943179545754335 0.267024827071749 0.894241954245832 0.75 5.2 5 2 anomalous pulmonary venous connection 0.0943179545754335 0.267024827071749 0.894241954245832 0.75 5.2 5 2 sinoatrial block 0.0943179545754335 0.267024827071749 0.894241954245832 0.75 5.2 5 2 delayed suture closure 0.0943179545754335 0.267024827071749 0.894241954245832 0.75 5.2 5 2 abnormal visual evoked potential 0.0943179545754335 0.267024827071749 0.894241954245832 0.75 5.2 5 2 abnormal foramen magnum morphology 0.0943179545754335 0.267024827071749 0.894241954245832 0.75 5.2 5 2 increased aorta wall thickness 0.0943179545754335 0.267024827071749 0.894241954245832 0.75 5.2 5 2 small thymus medulla 0.0943179545754335 0.267024827071749 0.894241954245832 0.75 5.2 5 2 increased testis apoptosis 0.0943179545754335 0.267024827071749 0.894241954245832 0.75 5.2 5 2 absent hypoglossal canal 0.0943179545754335 0.267024827071749 0.894241954245832 0.75 5.2 5 2 abnormal umbilical vein topology 0.0943179545754335 0.267024827071749 0.894241954245832 0.75 5.2 5 2 increased brain apoptosis 0.0943179545754335 0.267024827071749 0.894241954245832 0.75 5.2 5 2 decreased basal metabolism 0.0943179545754335 0.267024827071749 0.894241954245832 0.75 5.2 5 2 pallor 2.98007149448711e-15 3.02568483368844e-13 0.892538636237745 0.748571428571429 5.2 5 2 cleft palate 9.54159672519985e-12 6.32925916104923e-10 0.891966529425868 0.748091603053435 5.2 5 2 double outlet right ventricle 7.89187338660075e-10 3.56927909984897e-08 0.891456153765315 0.747663551401869 5.2 5 2 decreased circulating serum albumin level 3.45062476980149e-09 1.36244906585416e-07 0.89123103857497 0.747474747474748 5.2 5 2 abnormal placenta morphology 1.39581622813848e-07 3.90122794100502e-06 0.890468781443107 0.746835443037975 5.2 5 2 abnormal head morphology 1.22770839180135e-05 0.000216590398908216 0.888822306038281 0.745454545454545 5.2 5 2 small lung 2.60542493450532e-05 0.00040380028190542 0.88839723559063 0.745098039215686 5.2 5 2 abnormal innervation 5.54356653634325e-05 0.000776880099107259 0.887899812726358 0.74468085106383 5.2 5 2 abnormal left-right axis patterning 0.000118312117669536 0.00141831996483359 0.887309846073383 0.744186046511628 5.2 5 2 kidney failure 0.000118312117669536 0.00141831996483359 0.887309846073383 0.744186046511628 5.2 5 2 abnormal developmental patterning 1.09686872064228e-07 3.13616200298582e-06 0.886971694455215 0.74390243902439 5.2 5 2 abnormal cornea morphology 2.30281944887652e-07 6.19271716657333e-06 0.886598860619799 0.743589743589744 5.2 5 2 abnormal action potential 1.01828581179263e-06 2.31322918432344e-05 0.885725364205395 0.742857142857143 5.2 5 2 impaired behavioral response to xenobiotic 0.00054526422396351 0.00516702764613041 0.885725364205395 0.742857142857143 5.2 5 2 impaired swimming 2.14532717706365e-06 4.56111226747507e-05 0.885209207233248 0.742424242424242 5.2 5 2 increased lung adenoma incidence 0.00117959424334946 0.0100426241641873 0.884626449361468 0.741935483870968 5.2 5 2 decreased double-negative T cell number 0.00117959424334946 0.0100426241641873 0.884626449361468 0.741935483870968 5.2 5 2 perinatal lethality, complete penetrance 1.87143516580315e-17 2.66011141424877e-15 0.88444587649979 0.741784037558685 5.2 5 2 decreased rib number 4.10178429883539e-08 1.28341992998151e-06 0.884194291838575 0.741573033707865 5.2 5 2 abnormal maxilla morphology 2.02582171424833e-05 0.000329819075333126 0.88320193011934 0.740740740740741 5.2 5 2 abnormal mandible morphology 2.02582171424833e-05 0.000329819075333126 0.88320193011934 0.740740740740741 5.2 5 2 abnormal cell adhesion 2.02582171424833e-05 0.000329819075333126 0.88320193011934 0.740740740740741 5.2 5 2 abnormal trigeminal ganglion morphology 0.00256955646439472 0.0186077778899036 0.88320193011934 0.740740740740741 5.2 5 2 thin epidermis 0.00256955646439472 0.0186077778899036 0.88320193011934 0.740740740740741 5.2 5 2 increased brain weight 0.00256955646439472 0.0186077778899036 0.88320193011934 0.740740740740741 5.2 5 2 decreased anxiety-related response 1.45260370902995e-10 7.45020974476699e-09 0.882124854594804 0.739837398373984 5.2 5 2 decreased body size 9.89304134252081e-61 9.8435761358082e-58 0.881541776115356 0.739348370927318 5.2 5 2 abnormal sleep pattern 9.14877095334087e-05 0.00115520648459063 0.881281925923428 0.739130434782609 5.2 5 2 abnormal nasal cavity morphology 0.00564787680416027 0.0352549399004986 0.881281925923428 0.739130434782609 5.2 5 2 decreased effector memory CD8-positive, alpha-beta T cell number 0.00564787680416027 0.0352549399004986 0.881281925923428 0.739130434782609 5.2 5 2 abnormal vertebral artery topology 0.00564787680416027 0.0352549399004986 0.881281925923428 0.739130434782609 5.2 5 2 decreased body length 2.30677746907977e-21 4.25045107728586e-19 0.879011555998336 0.737226277372263 5.2 5 2 abnormal craniofacial bone morphology 1.56981917041102e-05 0.000267890154227676 0.878553498908186 0.736842105263158 5.2 5 2 increased grooming behavior 0.000418341588268281 0.00407289511083111 0.878553498908186 0.736842105263158 5.2 5 2 impaired branching involved in ureteric bud morphogenesis 0.000418341588268281 0.00407289511083111 0.878553498908186 0.736842105263158 5.2 5 2 enlarged adrenal glands 0.0125656571830389 0.0665044090272536 0.878553498908186 0.736842105263158 5.2 5 2 abnormal stationary movement 0.0125656571830389 0.0665044090272536 0.878553498908186 0.736842105263158 5.2 5 2 unresponsive to tactile stimuli 0.0125656571830389 0.0665044090272536 0.878553498908186 0.736842105263158 5.2 5 2 decreased chemically-elicited antinociception 0.0125656571830389 0.0665044090272536 0.878553498908186 0.736842105263158 5.2 5 2 increased liver adenoma incidence 0.0125656571830389 0.0665044090272536 0.878553498908186 0.736842105263158 5.2 5 2 abnormal optic vesicle formation 0.0125656571830389 0.0665044090272536 0.878553498908186 0.736842105263158 5.2 5 2 abnormal photoreceptor inner segment morphology 0.0125656571830389 0.0665044090272536 0.878553498908186 0.736842105263158 5.2 5 2 decreased eye pigmentation 0.0125656571830389 0.0665044090272536 0.878553498908186 0.736842105263158 5.2 5 2 Leydig cell hypoplasia 0.0125656571830389 0.0665044090272536 0.878553498908186 0.736842105263158 5.2 5 2 abnormal behavioral response to xenobiotic 0.0125656571830389 0.0665044090272536 0.878553498908186 0.736842105263158 5.2 5 2 abnormal forebrain development 1.29998416495365e-06 2.91325280209208e-05 0.877681918056094 0.736111111111111 5.2 5 2 abnormal mesoderm development 3.32311853754699e-05 0.00049647191364253 0.87736946454308 0.735849056603774 5.2 5 2 enlarged kidney 3.32311853754699e-05 0.00049647191364253 0.87736946454308 0.735849056603774 5.2 5 2 atrioventricular septal defect 3.32311853754699e-05 0.00049647191364253 0.87736946454308 0.735849056603774 5.2 5 2 pericardial edema 2.73331152849956e-06 5.7376476178419e-05 0.876707798280227 0.735294117647059 5.2 5 2 abnormal endoderm development 0.00090021943625848 0.00795486979642263 0.876707798280227 0.735294117647059 5.2 5 2 abnormal nervous system development 0.00090021943625848 0.00795486979642263 0.876707798280227 0.735294117647059 5.2 5 2 abnormal direction of heart looping 0.00090021943625848 0.00795486979642263 0.876707798280227 0.735294117647059 5.2 5 2 pale yolk sac 2.29474183277811e-07 6.19271716657333e-06 0.876285288497923 0.734939759036145 5.2 5 2 abnormal long bone hypertrophic chondrocyte zone 7.05009347722481e-05 0.000950520733040473 0.875992118444896 0.73469387755102 5.2 5 2 abnormal craniofacial development 7.05009347722481e-05 0.000950520733040473 0.875992118444896 0.73469387755102 5.2 5 2 increased sacral vertebrae number 5.75409712648799e-06 0.000110044787875346 0.875611913532377 0.734375 5.2 5 2 abnormal nervous system morphology 4.80787596329586e-07 1.18411796620777e-05 0.875376090232207 0.734177215189873 5.2 5 2 delayed eyelid opening 0.00194783889013932 0.0151414038725673 0.874369910818147 0.733333333333333 5.2 5 2 abnormal microglial cell physiology 0.00194783889013932 0.0151414038725673 0.874369910818147 0.733333333333333 5.2 5 2 abnormal brain vasculature morphology 0.00194783889013932 0.0151414038725673 0.874369910818147 0.733333333333333 5.2 5 2 decreased hepatocyte number 0.0284444842291743 0.124628068570298 0.874369910818147 0.733333333333333 5.2 5 2 abnormal prostate gland morphology 0.0284444842291743 0.124628068570298 0.874369910818147 0.733333333333333 5.2 5 2 hyperpigmentation 0.0284444842291743 0.124628068570298 0.874369910818147 0.733333333333333 5.2 5 2 abnormal apical ectodermal ridge morphology 0.0284444842291743 0.124628068570298 0.874369910818147 0.733333333333333 5.2 5 2 absent egg cylinders 0.0284444842291743 0.124628068570298 0.874369910818147 0.733333333333333 5.2 5 2 dilated ureter 0.0284444842291743 0.124628068570298 0.874369910818147 0.733333333333333 5.2 5 2 immune system phenotype 0.0284444842291743 0.124628068570298 0.874369910818147 0.733333333333333 5.2 5 2 abnormal neurotransmitter secretion 0.0284444842291743 0.124628068570298 0.874369910818147 0.733333333333333 5.2 5 2 abnormal energy homeostasis 0.0284444842291743 0.124628068570298 0.874369910818147 0.733333333333333 5.2 5 2 abnormal cerebral aqueduct morphology 0.0284444842291743 0.124628068570298 0.874369910818147 0.733333333333333 5.2 5 2 trabecula carnea hypoplasia 0.000149952355016039 0.00174710296535081 0.874369910818147 0.733333333333333 5.2 5 2 cardiomyopathy 0.000149952355016039 0.00174710296535081 0.874369910818147 0.733333333333333 5.2 5 2 increased circulating creatinine level 1.78136755731068e-07 4.89630033017714e-06 0.873445629728487 0.732558139534884 5.2 5 2 decreased liver weight 2.11598121345307e-06 4.53750281764182e-05 0.873250359075742 0.732394366197183 5.2 5 2 hemopericardium 0.000319901545725311 0.00328824419418062 0.872431174873982 0.731707317073171 5.2 5 2 palatal shelves fail to meet at midline 0.000319901545725311 0.00328824419418062 0.872431174873982 0.731707317073171 5.2 5 2 decreased kidney weight 5.4178161659481e-05 0.000763559077212232 0.871312673367734 0.730769230769231 5.2 5 2 abnormal female meiosis 5.4178161659481e-05 0.000763559077212232 0.871312673367734 0.730769230769231 5.2 5 2 abnormal nasal bone morphology 0.00424395135830981 0.0282646024198009 0.871312673367734 0.730769230769231 5.2 5 2 abnormal xiphoid process morphology 0.00424395135830981 0.0282646024198009 0.871312673367734 0.730769230769231 5.2 5 2 abnormal kidney cortex morphology 0.00424395135830981 0.0282646024198009 0.871312673367734 0.730769230769231 5.2 5 2 increased leukemia incidence 0.00424395135830981 0.0282646024198009 0.871312673367734 0.730769230769231 5.2 5 2 abnormal Mullerian duct morphology 0.00424395135830981 0.0282646024198009 0.871312673367734 0.730769230769231 5.2 5 2 absent gastric milk in neonates 7.80234223456998e-07 1.83965178279553e-05 0.871312673367733 0.730769230769231 5.2 5 2 decreased total body fat amount 1.48334800472501e-24 3.35438923795768e-22 0.871038071201529 0.730538922155689 5.2 5 2 increased startle reflex 1.38030607830783e-07 3.87967386417031e-06 0.8707974086289 0.730337078651685 5.2 5 2 prenatal lethality, incomplete penetrance 1.9485824431683e-22 3.87767906190491e-20 0.870709271239362 0.730263157894737 5.2 5 2 decreased double-positive T cell number 2.45643176857025e-08 8.23386434866541e-07 0.87039550213261 0.73 5.2 5 2 decreased leukocyte cell number 6.82557404428797e-11 3.81541919891378e-09 0.870308471285481 0.72992700729927 5.2 5 2 increased circulating phosphate level 0.000684907401407287 0.00624068557143087 0.870073252779728 0.72972972972973 5.2 5 2 increased erythroid progenitor cell number 0.000684907401407287 0.00624068557143087 0.870073252779728 0.72972972972973 5.2 5 2 premature death 6.12109549478119e-61 7.61311252163411e-58 0.869661552096604 0.72938443670151 5.2 5 2 overriding aortic valve 0.000114841178550888 0.00139217981502111 0.869401899961225 0.729166666666667 5.2 5 2 ventricular septal defect 1.09952788511692e-10 5.8193098175071e-09 0.867940720297425 0.727941176470588 5.2 5 2 increased insulin sensitivity 4.11078003214842e-11 2.37803844883005e-09 0.867143713208079 0.727272727272727 5.2 5 2 dextrocardia 0.00147272239383875 0.0120705006743786 0.867143713208079 0.727272727272727 5.2 5 2 abnormal germ layer development 0.00933039166733349 0.0529289607126387 0.867143713208079 0.727272727272727 5.2 5 2 prolonged PR interval 0.00933039166733349 0.0529289607126387 0.867143713208079 0.727272727272727 5.2 5 2 abnormal occipital bone morphology 0.00933039166733349 0.0529289607126387 0.867143713208079 0.727272727272727 5.2 5 2 increased adenoma incidence 0.00933039166733349 0.0529289607126387 0.867143713208079 0.727272727272727 5.2 5 2 increased bone volume 0.00933039166733349 0.0529289607126387 0.867143713208079 0.727272727272727 5.2 5 2 abnormal ear position 0.0661262342565024 0.224252225920995 0.867143713208079 0.727272727272727 5.2 5 2 abnormal sphenoid bone morphology 0.0661262342565024 0.224252225920995 0.867143713208079 0.727272727272727 5.2 5 2 abnormal thrombopoiesis 0.0661262342565024 0.224252225920995 0.867143713208079 0.727272727272727 5.2 5 2 delayed hepatic development 0.0661262342565024 0.224252225920995 0.867143713208079 0.727272727272727 5.2 5 2 abnormal glossopharyngeal ganglion morphology 0.0661262342565024 0.224252225920995 0.867143713208079 0.727272727272727 5.2 5 2 social withdrawal 0.0661262342565024 0.224252225920995 0.867143713208079 0.727272727272727 5.2 5 2 abnormal hypothalamus secretion 0.0661262342565024 0.224252225920995 0.867143713208079 0.727272727272727 5.2 5 2 vasculitis 0.0661262342565024 0.224252225920995 0.867143713208079 0.727272727272727 5.2 5 2 abnormal fear/anxiety-related behavior 0.0661262342565024 0.224252225920995 0.867143713208079 0.727272727272727 5.2 5 2 abnormal primary sex determination 0.0661262342565024 0.224252225920995 0.867143713208079 0.727272727272727 5.2 5 2 fatigue 0.0661262342565024 0.224252225920995 0.867143713208079 0.727272727272727 5.2 5 2 abnormal ureter development 0.0661262342565024 0.224252225920995 0.867143713208079 0.727272727272727 5.2 5 2 abnormal pituitary gland development 0.0661262342565024 0.224252225920995 0.867143713208079 0.727272727272727 5.2 5 2 increased motor neuron number 0.0661262342565024 0.224252225920995 0.867143713208079 0.727272727272727 5.2 5 2 increased circulating triiodothyronine level 0.0661262342565024 0.224252225920995 0.867143713208079 0.727272727272727 5.2 5 2 enhanced behavioral response to addictive substance 0.0661262342565024 0.224252225920995 0.867143713208079 0.727272727272727 5.2 5 2 palatal shelf hypoplasia 0.0661262342565024 0.224252225920995 0.867143713208079 0.727272727272727 5.2 5 2 aorta dilation 0.0661262342565024 0.224252225920995 0.867143713208079 0.727272727272727 5.2 5 2 abnormal extraembryonic ectoderm morphology 0.0661262342565024 0.224252225920995 0.867143713208079 0.727272727272727 5.2 5 2 abnormal brain morphology 2.77815098012402e-12 2.09413653426015e-10 0.866470464983539 0.726708074534162 5.2 5 2 lethality throughout fetal growth and development, complete penetrance 3.41111894582376e-14 2.97724855359179e-12 0.866002734638069 0.726315789473684 5.2 5 2 decreased erythrocyte cell number 5.75255178305021e-12 3.92040344118833e-10 0.865762911116984 0.726114649681529 5.2 5 2 increased tumor incidence 9.81782030786329e-10 4.27679321371685e-08 0.86539543959274 0.725806451612903 5.2 5 2 abnormal gastrulation 8.77658048173998e-05 0.00113117844291856 0.865018360969824 0.725490196078431 5.2 5 2 abnormal cervical vertebrae morphology 8.77658048173998e-05 0.00113117844291856 0.865018360969824 0.725490196078431 5.2 5 2 abnormal locomotor activation 1.71818847636376e-07 4.74888203883873e-06 0.864761450259705 0.725274725274725 5.2 5 2 decreased spleen weight 5.5254813412476e-06 0.000107801057540027 0.864001888160224 0.72463768115942 5.2 5 2 abnormal enzyme/coenzyme level 3.17934657340461e-05 0.000482233207399023 0.863406024789079 0.724137931034483 5.2 5 2 thrombocytosis 3.17934657340461e-05 0.000482233207399023 0.863406024789079 0.724137931034483 5.2 5 2 decreased trophoblast giant cell number 0.00318353303643778 0.0226870965599749 0.863406024789079 0.724137931034483 5.2 5 2 abnormal cranium morphology 2.83045905412555e-10 1.38054252885045e-08 0.863099199620355 0.723880597014925 5.2 5 2 abnormal spermatogenesis 1.80630872746233e-13 1.44941708372985e-11 0.861841883439823 0.722826086956522 5.2 5 2 abnormal chondrocyte morphology 6.69609027812346e-05 0.000917714852167058 0.861121881866357 0.722222222222222 5.2 5 2 increased cell proliferation 6.69609027812346e-05 0.000917714852167058 0.861121881866357 0.722222222222222 5.2 5 2 heart right ventricle hypertrophy 0.00111161202890338 0.00966830392271737 0.861121881866357 0.722222222222222 5.2 5 2 abnormal lysosome morphology 0.00111161202890338 0.00966830392271737 0.861121881866357 0.722222222222222 5.2 5 2 cortical renal glomerulopathies 0.0207635836930292 0.0953821134559743 0.861121881866357 0.722222222222222 5.2 5 2 blepharoptosis 0.0207635836930292 0.0953821134559743 0.861121881866357 0.722222222222222 5.2 5 2 abnormal bile duct morphology 0.0207635836930292 0.0953821134559743 0.861121881866357 0.722222222222222 5.2 5 2 absent allantois 0.0207635836930292 0.0953821134559743 0.861121881866357 0.722222222222222 5.2 5 2 increased circulating glycerol level 0.0207635836930292 0.0953821134559743 0.861121881866357 0.722222222222222 5.2 5 2 abnormal anterior eye segment morphology 0.0207635836930292 0.0953821134559743 0.861121881866357 0.722222222222222 5.2 5 2 abnormal eye anterior chamber morphology 0.0207635836930292 0.0953821134559743 0.861121881866357 0.722222222222222 5.2 5 2 jerky movement 0.0207635836930292 0.0953821134559743 0.861121881866357 0.722222222222222 5.2 5 2 small thoracic cage 0.0207635836930292 0.0953821134559743 0.861121881866357 0.722222222222222 5.2 5 2 atrioventricular block 0.0207635836930292 0.0953821134559743 0.861121881866357 0.722222222222222 5.2 5 2 increased effector memory CD8-positive, alpha-beta T cell number 0.0207635836930292 0.0953821134559743 0.861121881866357 0.722222222222222 5.2 5 2 postnatal lethality, incomplete penetrance 2.62895612326637e-38 1.18900515575002e-35 0.860655401973688 0.721830985915493 5.2 5 2 impaired glucose tolerance 1.64134170016194e-17 2.40166910538401e-15 0.860587687150558 0.721774193548387 5.2 5 2 abnormal double-strand DNA break repair 0.000394098757142076 0.00386714263665055 0.85958141338359 0.720930232558139 5.2 5 2 decreased body weight 4.32446221359704e-82 2.15141995126453e-78 0.859088662560347 0.720516962843296 5.2 5 2 abnormal bone structure 8.32133653780019e-14 6.89977487925933e-12 0.8587193895694 0.72020725388601 5.2 5 2 kyphosis 4.85212934498583e-11 2.77463718290856e-09 0.858472276075998 0.72 5.2 5 2 decreased respiratory quotient 0.000141231313604557 0.00167291853614922 0.858472276075998 0.72 5.2 5 2 abnormal thyroid gland morphology 0.00692753484136031 0.0424962833979871 0.858472276075998 0.72 5.2 5 2 increased hepatocellular carcinoma incidence 5.10185212299212e-05 0.000725191837482451 0.857635558457991 0.719298245614035 5.2 5 2 microphthalmia 3.73813351084415e-11 2.18790755487643e-09 0.857225402762889 0.718954248366013 5.2 5 2 abnormal vertebral body morphology 0.00238600003919753 0.0179310425906461 0.856981872818922 0.71875 5.2 5 2 increased circulating follicle stimulating hormone level 0.00238600003919753 0.0179310425906461 0.856981872818922 0.71875 5.2 5 2 bradykinesia 0.00238600003919753 0.0179310425906461 0.856981872818922 0.71875 5.2 5 2 increased hepatocyte apoptosis 0.000838119132202241 0.00755370051214882 0.856026486115668 0.717948717948718 5.2 5 2 cardiac fibrosis 9.13498668944417e-07 2.10400735092522e-05 0.855666811121502 0.717647058823529 5.2 5 2 increased mean corpuscular hemoglobin 1.24542007883603e-07 3.53540972010487e-06 0.855100050524634 0.717171717171717 5.2 5 2 decreased compact bone thickness 1.41381524059946e-05 0.000244226764652164 0.854201269727362 0.716417910447761 5.2 5 2 decreased bone mineral content 2.25954120545752e-14 2.04385772675476e-12 0.85411571270916 0.716346153846154 5.2 5 2 anemia 1.73823607850243e-14 1.63164613029237e-12 0.853273523482595 0.71563981042654 5.2 5 2 postnatal lethality, complete penetrance 3.6264652843732e-25 9.02083239487833e-23 0.852541552234368 0.715025906735751 5.2 5 2 abnormal eye development 8.13626613416715e-05 0.00105411260462192 0.851659004043649 0.714285714285714 5.2 5 2 increased sarcoma incidence 0.000225691787997485 0.00241986345967131 0.851659004043649 0.714285714285714 5.2 5 2 decreased circulating creatinine level 0.000225691787997485 0.00241986345967131 0.851659004043649 0.714285714285714 5.2 5 2 abnormal optic nerve morphology 0.00063146583251181 0.0058555904808005 0.851659004043649 0.714285714285714 5.2 5 2 spina bifida 0.00063146583251181 0.0058555904808005 0.851659004043649 0.714285714285714 5.2 5 2 increased carcinoma incidence 0.00178760746699591 0.0144842787431672 0.851659004043649 0.714285714285714 5.2 5 2 shortened head 0.00514611144458233 0.0324563386720429 0.851659004043649 0.714285714285714 5.2 5 2 small superior cervical ganglion 0.00514611144458233 0.0324563386720429 0.851659004043649 0.714285714285714 5.2 5 2 hypoxia 0.00514611144458233 0.0324563386720429 0.851659004043649 0.714285714285714 5.2 5 2 prolonged QRS complex duration 0.00514611144458233 0.0324563386720429 0.851659004043649 0.714285714285714 5.2 5 2 abnormal scapula morphology 0.0152037396501525 0.0777375177384469 0.851659004043649 0.714285714285714 5.2 5 2 abnormal erythrocyte physiology 0.0152037396501525 0.0777375177384469 0.851659004043649 0.714285714285714 5.2 5 2 abnormal clavicle morphology 0.0152037396501525 0.0777375177384469 0.851659004043649 0.714285714285714 5.2 5 2 increased muscle cell glucose uptake 0.0152037396501525 0.0777375177384469 0.851659004043649 0.714285714285714 5.2 5 2 abnormal interparietal bone morphology 0.0470089217760443 0.171836433384144 0.851659004043649 0.714285714285714 5.2 5 2 megacephaly 0.0470089217760443 0.171836433384144 0.851659004043649 0.714285714285714 5.2 5 2 irregularly shaped pupil 0.0470089217760443 0.171836433384144 0.851659004043649 0.714285714285714 5.2 5 2 increased aggression towards males 0.0470089217760443 0.171836433384144 0.851659004043649 0.714285714285714 5.2 5 2 abnormal kidney medulla morphology 0.0470089217760443 0.171836433384144 0.851659004043649 0.714285714285714 5.2 5 2 abnormal prepulse inhibition 0.0470089217760443 0.171836433384144 0.851659004043649 0.714285714285714 5.2 5 2 abnormal uterus development 0.0470089217760443 0.171836433384144 0.851659004043649 0.714285714285714 5.2 5 2 abnormal maternal decidual layer morphology 0.0470089217760443 0.171836433384144 0.851659004043649 0.714285714285714 5.2 5 2 decreased CNS synapse formation 0.0470089217760443 0.171836433384144 0.851659004043649 0.714285714285714 5.2 5 2 abnormal iris pigmentation 0.0470089217760443 0.171836433384144 0.851659004043649 0.714285714285714 5.2 5 2 spina bifida occulta 0.0470089217760443 0.171836433384144 0.851659004043649 0.714285714285714 5.2 5 2 decreased cornea thickness 0.0470089217760443 0.171836433384144 0.851659004043649 0.714285714285714 5.2 5 2 decreased tongue size 0.0470089217760443 0.171836433384144 0.851659004043649 0.714285714285714 5.2 5 2 pulmonary alveolar hemorrhage 0.0470089217760443 0.171836433384144 0.851659004043649 0.714285714285714 5.2 5 2 decreased compact bone area 0.0470089217760443 0.171836433384144 0.851659004043649 0.714285714285714 5.2 5 2 cellular necrosis 0.16102506158178 0.391927437069156 0.851659004043649 0.714285714285714 5.2 5 2 polyphalangy 0.16102506158178 0.391927437069156 0.851659004043649 0.714285714285714 5.2 5 2 abnormal foot pad morphology 0.16102506158178 0.391927437069156 0.851659004043649 0.714285714285714 5.2 5 2 small L4 dorsal root ganglion 0.16102506158178 0.391927437069156 0.851659004043649 0.714285714285714 5.2 5 2 absent epidermis stratum corneum 0.16102506158178 0.391927437069156 0.851659004043649 0.714285714285714 5.2 5 2 abnormal circulating free fatty acids level 0.16102506158178 0.391927437069156 0.851659004043649 0.714285714285714 5.2 5 2 increased chemically-elicited antinociception 0.16102506158178 0.391927437069156 0.851659004043649 0.714285714285714 5.2 5 2 increased colonic adenoma incidence 0.16102506158178 0.391927437069156 0.851659004043649 0.714285714285714 5.2 5 2 abnormal melanocyte morphology 0.16102506158178 0.391927437069156 0.851659004043649 0.714285714285714 5.2 5 2 abnormal inhibitory postsynaptic potential 0.16102506158178 0.391927437069156 0.851659004043649 0.714285714285714 5.2 5 2 increased retinal ganglion cell number 0.16102506158178 0.391927437069156 0.851659004043649 0.714285714285714 5.2 5 2 decreased urine calcium level 0.16102506158178 0.391927437069156 0.851659004043649 0.714285714285714 5.2 5 2 decreased cardiomyocyte apoptosis 0.16102506158178 0.391927437069156 0.851659004043649 0.714285714285714 5.2 5 2 abnormal sinus venosus morphology 0.16102506158178 0.391927437069156 0.851659004043649 0.714285714285714 5.2 5 2 abnormal prostate gland physiology 0.16102506158178 0.391927437069156 0.851659004043649 0.714285714285714 5.2 5 2 skeletal muscle interstitial fibrosis 0.16102506158178 0.391927437069156 0.851659004043649 0.714285714285714 5.2 5 2 renal necrosis 0.16102506158178 0.391927437069156 0.851659004043649 0.714285714285714 5.2 5 2 absent vestibular hair cells 0.16102506158178 0.391927437069156 0.851659004043649 0.714285714285714 5.2 5 2 absent endocochlear potential 0.16102506158178 0.391927437069156 0.851659004043649 0.714285714285714 5.2 5 2 abnormal negative T cell selection 0.16102506158178 0.391927437069156 0.851659004043649 0.714285714285714 5.2 5 2 abnormal talus morphology 0.16102506158178 0.391927437069156 0.851659004043649 0.714285714285714 5.2 5 2 decreased adrenocorticotropin level 0.16102506158178 0.391927437069156 0.851659004043649 0.714285714285714 5.2 5 2 increased thyroid-stimulating hormone level 0.16102506158178 0.391927437069156 0.851659004043649 0.714285714285714 5.2 5 2 abnormal renal filtration rate 0.16102506158178 0.391927437069156 0.851659004043649 0.714285714285714 5.2 5 2 decreased tidal volume 0.16102506158178 0.391927437069156 0.851659004043649 0.714285714285714 5.2 5 2 enhanced behavioral response to alcohol 0.16102506158178 0.391927437069156 0.851659004043649 0.714285714285714 5.2 5 2 decreased behavioral withdrawal response 0.16102506158178 0.391927437069156 0.851659004043649 0.714285714285714 5.2 5 2 abnormal sperm annulus morphology 0.16102506158178 0.391927437069156 0.851659004043649 0.714285714285714 5.2 5 2 abnormal cerebellum white matter morphology 0.16102506158178 0.391927437069156 0.851659004043649 0.714285714285714 5.2 5 2 decreased DN4 thymocyte number 0.16102506158178 0.391927437069156 0.851659004043649 0.714285714285714 5.2 5 2 arteritis 0.16102506158178 0.391927437069156 0.851659004043649 0.714285714285714 5.2 5 2 increased oligodendrocyte number 0.16102506158178 0.391927437069156 0.851659004043649 0.714285714285714 5.2 5 2 increased quadriceps weight 0.16102506158178 0.391927437069156 0.851659004043649 0.714285714285714 5.2 5 2 heart block 0.16102506158178 0.391927437069156 0.851659004043649 0.714285714285714 5.2 5 2 thick pulmonary valve 0.16102506158178 0.391927437069156 0.851659004043649 0.714285714285714 5.2 5 2 thick mitral valve cusps 0.16102506158178 0.391927437069156 0.851659004043649 0.714285714285714 5.2 5 2 altered tumor pathology 0.16102506158178 0.391927437069156 0.851659004043649 0.714285714285714 5.2 5 2 abnormal impulsive behavior control 0.16102506158178 0.391927437069156 0.851659004043649 0.714285714285714 5.2 5 2 dilated pulmonary alveolar ducts 0.16102506158178 0.391927437069156 0.851659004043649 0.714285714285714 5.2 5 2 small lung lobe 0.16102506158178 0.391927437069156 0.851659004043649 0.714285714285714 5.2 5 2 impaired branching involved in bronchus morphogenesis 0.16102506158178 0.391927437069156 0.851659004043649 0.714285714285714 5.2 5 2 parturition failure 0.16102506158178 0.391927437069156 0.851659004043649 0.714285714285714 5.2 5 2 small tail bud 0.16102506158178 0.391927437069156 0.851659004043649 0.714285714285714 5.2 5 2 decreased CD8-positive, naive alpha-beta T cell number 0.16102506158178 0.391927437069156 0.851659004043649 0.714285714285714 5.2 5 2 decreased areal bone mineral density 0.16102506158178 0.391927437069156 0.851659004043649 0.714285714285714 5.2 5 2 abnormal Mullerian duct topology 0.16102506158178 0.391927437069156 0.851659004043649 0.714285714285714 5.2 5 2 fragmented Meckel's cartilage 0.16102506158178 0.391927437069156 0.851659004043649 0.714285714285714 5.2 5 2 absent connection between subcutaneous lymph vessels and lymph sac 0.16102506158178 0.391927437069156 0.851659004043649 0.714285714285714 5.2 5 2 embryo tumor 0.16102506158178 0.391927437069156 0.851659004043649 0.714285714285714 5.2 5 2 decreased collagen level 0.16102506158178 0.391927437069156 0.851659004043649 0.714285714285714 5.2 5 2 hydroencephaly 2.07401994663921e-08 7.06729399625346e-07 0.85017785794966 0.71304347826087 5.2 5 2 short snout 5.59039231628542e-08 1.72746594866584e-06 0.850081857739865 0.712962962962963 5.2 5 2 abnormal social investigation 3.00703020830392e-06 6.18180796955041e-05 0.84952985653354 0.7125 5.2 5 2 decreased bone marrow cell number 8.1977646136383e-06 0.000149940731444303 0.849325691703804 0.712328767123288 5.2 5 2 increased anxiety-related response 8.17489512113368e-10 3.66397326375136e-08 0.849208186765826 0.712230215827338 5.2 5 2 kinked neural tube 0.000170615324606933 0.00194681477045755 0.848383392489635 0.711538461538462 5.2 5 2 abnormal myocardial fiber morphology 3.1164690241489e-07 8.11750439536167e-06 0.848147008150686 0.711340206185567 5.2 5 2 increased circulating corticosterone level 0.000475557263218938 0.00455856914164589 0.847873852914566 0.711111111111111 5.2 5 2 short tail 2.29073008156374e-06 4.84952432160835e-05 0.84755462330127 0.710843373493976 5.2 5 2 postnatal growth retardation 6.89086326278421e-38 2.63708036402704e-35 0.84748420500422 0.71078431372549 5.2 5 2 hemorrhage 2.09953710281424e-15 2.27069501880453e-13 0.847310107001724 0.71063829787234 5.2 5 2 abnormal axial skeleton morphology 6.23602564752243e-06 0.000117072556967638 0.847176588232893 0.710526315789474 5.2 5 2 persistence of hyaloid vascular system 0.00133920530638483 0.0111227819687221 0.847176588232893 0.710526315789474 5.2 5 2 hyporesponsive to tactile stimuli 0.00133920530638483 0.0111227819687221 0.847176588232893 0.710526315789474 5.2 5 2 infertility 8.80696976158089e-08 2.57380813227732e-06 0.846883346077049 0.710280373831776 5.2 5 2 abnormal sternum morphology 1.70357284903379e-05 0.000285362792051957 0.846721850397019 0.710144927536232 5.2 5 2 perimembraneous ventricular septal defect 1.70357284903379e-05 0.000285362792051957 0.846721850397019 0.710144927536232 5.2 5 2 increased circulating alkaline phosphatase level 5.1089485341263e-11 2.88829760878163e-09 0.846401849697701 0.709876543209877 5.2 5 2 hypoglycemia 6.43281346918802e-07 1.56113400044929e-05 0.846164429824013 0.709677419354839 5.2 5 2 abnormal eyelid morphology 0.00382577024895897 0.0264350097063484 0.846164429824013 0.709677419354839 5.2 5 2 abnormal retinal photoreceptor layer morphology 0.00382577024895897 0.0264350097063484 0.846164429824013 0.709677419354839 5.2 5 2 edema 1.46113092493031e-11 9.20142576142819e-10 0.845717197038694 0.709302325581395 5.2 5 2 decreased circulating calcium level 0.000128921333066635 0.00153809024461993 0.845465120377877 0.709090909090909 5.2 5 2 abnormal rostral-caudal axis patterning 0.000128921333066635 0.00153809024461993 0.845465120377877 0.709090909090909 5.2 5 2 abnormal placenta labyrinth morphology 4.74115814787469e-06 9.3230283737852e-05 0.845190707810406 0.708860759493671 5.2 5 2 embryonic lethality during organogenesis, incomplete penetrance 6.73639078132395e-15 6.57128316413464e-13 0.844993846620699 0.708695652173913 5.2 5 2 curly tail 0.000358052010520638 0.003584122238109 0.844561845676619 0.708333333333333 5.2 5 2 decreased body height 0.0111650306991715 0.0602451493800199 0.844561845676619 0.708333333333333 5.2 5 2 abnormal tumor morphology 0.0111650306991715 0.0602451493800199 0.844561845676619 0.708333333333333 5.2 5 2 increased body temperature 0.0111650306991715 0.0602451493800199 0.844561845676619 0.708333333333333 5.2 5 2 abnormal lung saccule morphology 0.0111650306991715 0.0602451493800199 0.844561845676619 0.708333333333333 5.2 5 2 neonatal lethality, incomplete penetrance 1.58748158132691e-16 1.92627338221985e-14 0.843797536314016 0.707692307692308 5.2 5 2 short humerus 0.00100340641650465 0.00883530428692152 0.843350135711516 0.707317073170732 5.2 5 2 abnormal spermiogenesis 9.73848315435021e-05 0.00119923941291403 0.842848738484577 0.706896551724138 5.2 5 2 decreased bone mineral density 9.29256043122867e-17 1.21659179329902e-14 0.842694172422137 0.706766917293233 5.2 5 2 abnormal neurocranium morphology 9.80936896007852e-06 0.000176817429624604 0.84257464133385 0.706666666666667 5.2 5 2 decreased circulating alanine transaminase level 2.68014345098467e-05 0.000414090486603999 0.841639486349018 0.705882352941177 5.2 5 2 abnormal response to novel object 0.000269548534693734 0.00282316623179226 0.841639486349018 0.705882352941177 5.2 5 2 abnormal trophoblast layer morphology 0.000269548534693734 0.00282316623179226 0.841639486349018 0.705882352941177 5.2 5 2 lung hemorrhage 0.0028467294920314 0.0204070305804845 0.841639486349018 0.705882352941177 5.2 5 2 abnormal bone remodeling 0.0028467294920314 0.0204070305804845 0.841639486349018 0.705882352941177 5.2 5 2 increased width of hypertrophic chondrocyte zone 0.0028467294920314 0.0204070305804845 0.841639486349018 0.705882352941177 5.2 5 2 decreased vasoconstriction 0.033746903556855 0.141450288708268 0.841639486349018 0.705882352941177 5.2 5 2 increased regulatory T cell number 0.033746903556855 0.141450288708268 0.841639486349018 0.705882352941177 5.2 5 2 pancytopenia 0.033746903556855 0.141450288708268 0.841639486349018 0.705882352941177 5.2 5 2 increased hepatoma incidence 0.033746903556855 0.141450288708268 0.841639486349018 0.705882352941177 5.2 5 2 abnormal survival 0.033746903556855 0.141450288708268 0.841639486349018 0.705882352941177 5.2 5 2 decreased body fat mass 0.033746903556855 0.141450288708268 0.841639486349018 0.705882352941177 5.2 5 2 abnormal cell cytoskeleton morphology 0.033746903556855 0.141450288708268 0.841639486349018 0.705882352941177 5.2 5 2 abnormal seminiferous tubule morphology 8.97214467900735e-10 3.98539462304121e-08 0.841159098514344 0.705479452054795 5.2 5 2 abnormal coat/hair pigmentation 8.02322991355834e-08 2.37592671547338e-06 0.841013266493104 0.705357142857143 5.2 5 2 increased osteoclast cell number 7.35460893284165e-05 0.000978320305906075 0.840489705629962 0.704918032786885 5.2 5 2 postnatal lethality 7.29645949247382e-11 4.03332066389525e-09 0.840371957002107 0.704819277108434 5.2 5 2 insulin resistance 6.4483363670327e-09 2.43033889590816e-07 0.840045472170327 0.704545454545455 5.2 5 2 abnormal suckling behavior 2.07830890989112e-06 4.47601161329364e-05 0.840045472170327 0.704545454545455 5.2 5 2 abnormal testis morphology 6.10902200659482e-08 1.86456346520302e-06 0.839809835291738 0.704347826086957 5.2 5 2 abnormal ovary morphology 2.02863592064194e-05 0.000329819075333126 0.839663806803598 0.704225352112676 5.2 5 2 rectal prolapse 0.00822063923135815 0.0490968549531894 0.839041833613373 0.703703703703704 5.2 5 2 abnormal type II pneumocyte morphology 0.00822063923135815 0.0490968549531894 0.839041833613373 0.703703703703704 5.2 5 2 abnormal single cell response 0.00822063923135815 0.0490968549531894 0.839041833613373 0.703703703703704 5.2 5 2 abnormal fetal cardiomyocyte proliferation 0.00822063923135815 0.0490968549531894 0.839041833613373 0.703703703703704 5.2 5 2 thick interventricular septum 0.00822063923135815 0.0490968549531894 0.839041833613373 0.703703703703704 5.2 5 2 decreased bone ossification 0.00822063923135815 0.0490968549531894 0.839041833613373 0.703703703703704 5.2 5 2 abnormal skeleton development 5.64036596179072e-06 0.000109186072606649 0.839041833613373 0.703703703703704 5.2 5 2 decreased heart weight 5.64036596179072e-06 0.000109186072606649 0.839041833613373 0.703703703703704 5.2 5 2 small spleen 1.57772399626891e-06 3.48852305841682e-05 0.838556557827593 0.703296703296703 5.2 5 2 small testis 7.68134933299764e-17 1.06151980365731e-14 0.838081831515417 0.702898550724638 5.2 5 2 abnormal long bone metaphysis morphology 0.0021201866029851 0.0162275820766936 0.83784831749159 0.702702702702703 5.2 5 2 abnormal calcium ion homeostasis 0.0021201866029851 0.0162275820766936 0.83784831749159 0.702702702702703 5.2 5 2 abnormal humerus morphology 0.0021201866029851 0.0162275820766936 0.83784831749159 0.702702702702703 5.2 5 2 increased trabecular bone volume 0.0021201866029851 0.0162275820766936 0.83784831749159 0.702702702702703 5.2 5 2 abnormal respiratory electron transport chain 0.0021201866029851 0.0162275820766936 0.83784831749159 0.702702702702703 5.2 5 2 abnormal hepatocyte morphology 1.25071781052956e-07 3.53540972010487e-06 0.83784831749159 0.702702702702703 5.2 5 2 cataract 3.53850506775376e-08 1.14312095532954e-06 0.837581995712349 0.702479338842975 5.2 5 2 neonatal lethality, complete penetrance 1.22374006442723e-26 3.204266747645e-24 0.836717618007796 0.701754385964912 5.2 5 2 decreased birth body size 9.50898948846387e-08 2.75041992471557e-06 0.836717618007796 0.701754385964912 5.2 5 2 abnormal circulating amino acid level 0.000152760638075201 0.00177566395893487 0.836717618007796 0.701754385964912 5.2 5 2 decreased white adipose tissue amount 4.19297348387501e-05 0.00061173146868851 0.836405409941375 0.701492537313433 5.2 5 2 hypoactivity 5.14962879719253e-22 9.85361664078187e-20 0.834942089905922 0.70026525198939 5.2 5 2 thin ventricular wall 2.45496203808248e-06 5.17518480485608e-05 0.834625823962776 0.7 5.2 5 2 abnormal eating behavior 0.000115012242004759 0.00139217981502111 0.834625823962776 0.7 5.2 5 2 increased erythrocyte cell number 0.000115012242004759 0.00139217981502111 0.834625823962776 0.7 5.2 5 2 abnormal incisor morphology 0.000115012242004759 0.00139217981502111 0.834625823962776 0.7 5.2 5 2 muscular ventricular septal defect 0.000115012242004759 0.00139217981502111 0.834625823962776 0.7 5.2 5 2 abnormal female reproductive system morphology 0.00158050968645765 0.012848097532887 0.834625823962776 0.7 5.2 5 2 abnormal lactation 0.00606681937780085 0.0374471791619842 0.834625823962776 0.7 5.2 5 2 disorganized myocardium 0.00606681937780085 0.0374471791619842 0.834625823962776 0.7 5.2 5 2 liver hemorrhage 0.00606681937780085 0.0374471791619842 0.834625823962776 0.7 5.2 5 2 abnormal basioccipital bone morphology 0.0244037080784242 0.109376979901046 0.834625823962776 0.7 5.2 5 2 abnormal pericardium morphology 0.0244037080784242 0.109376979901046 0.834625823962776 0.7 5.2 5 2 abnormal lens epithelium morphology 0.0244037080784242 0.109376979901046 0.834625823962776 0.7 5.2 5 2 dilated vasculature 0.0244037080784242 0.109376979901046 0.834625823962776 0.7 5.2 5 2 retarded hair growth 0.109256361998167 0.298326235423096 0.834625823962776 0.7 5.2 5 2 jaundice 0.109256361998167 0.298326235423096 0.834625823962776 0.7 5.2 5 2 enlarged testis 0.109256361998167 0.298326235423096 0.834625823962776 0.7 5.2 5 2 abnormal prostate gland epithelium morphology 0.109256361998167 0.298326235423096 0.834625823962776 0.7 5.2 5 2 abnormal epidermis suprabasal layer morphology 0.109256361998167 0.298326235423096 0.834625823962776 0.7 5.2 5 2 abnormal grooming behavior 0.109256361998167 0.298326235423096 0.834625823962776 0.7 5.2 5 2 abnormal pituitary secretion 0.109256361998167 0.298326235423096 0.834625823962776 0.7 5.2 5 2 abnormal immune cell physiology 0.109256361998167 0.298326235423096 0.834625823962776 0.7 5.2 5 2 abnormal PNS synaptic transmission 0.109256361998167 0.298326235423096 0.834625823962776 0.7 5.2 5 2 abnormal bone healing 0.109256361998167 0.298326235423096 0.834625823962776 0.7 5.2 5 2 abnormal scala media morphology 0.109256361998167 0.298326235423096 0.834625823962776 0.7 5.2 5 2 peritoneal inflammation 0.109256361998167 0.298326235423096 0.834625823962776 0.7 5.2 5 2 cochlear ganglion hypoplasia 0.109256361998167 0.298326235423096 0.834625823962776 0.7 5.2 5 2 abnormal embryonic erythrocyte morphology 0.109256361998167 0.298326235423096 0.834625823962776 0.7 5.2 5 2 abnormal respiratory conducting tube morphology 0.109256361998167 0.298326235423096 0.834625823962776 0.7 5.2 5 2 decreased cochlear inner hair cell number 0.109256361998167 0.298326235423096 0.834625823962776 0.7 5.2 5 2 increased platelet aggregation 0.109256361998167 0.298326235423096 0.834625823962776 0.7 5.2 5 2 ventricular premature beat 0.109256361998167 0.298326235423096 0.834625823962776 0.7 5.2 5 2 abnormal sperm principal piece morphology 0.109256361998167 0.298326235423096 0.834625823962776 0.7 5.2 5 2 protruding tongue 0.109256361998167 0.298326235423096 0.834625823962776 0.7 5.2 5 2 decreased transitional stage T2 B cell number 0.109256361998167 0.298326235423096 0.834625823962776 0.7 5.2 5 2 abnormal retinal blood vessel pattern 0.109256361998167 0.298326235423096 0.834625823962776 0.7 5.2 5 2 umbilical hernia 0.109256361998167 0.298326235423096 0.834625823962776 0.7 5.2 5 2 acanthocytosis 0.109256361998167 0.298326235423096 0.834625823962776 0.7 5.2 5 2 increased T-helper 17 cell number 0.109256361998167 0.298326235423096 0.834625823962776 0.7 5.2 5 2 increased kidney iron level 0.109256361998167 0.298326235423096 0.834625823962776 0.7 5.2 5 2 abnormal heart and great artery attachment 0.109256361998167 0.298326235423096 0.834625823962776 0.7 5.2 5 2 common ventricle 0.109256361998167 0.298326235423096 0.834625823962776 0.7 5.2 5 2 aorta stenosis 0.109256361998167 0.298326235423096 0.834625823962776 0.7 5.2 5 2 abnormal left subclavian artery morphology 0.109256361998167 0.298326235423096 0.834625823962776 0.7 5.2 5 2 thick aortic valve cusps 0.109256361998167 0.298326235423096 0.834625823962776 0.7 5.2 5 2 decreased trabecular bone connectivity density 0.109256361998167 0.298326235423096 0.834625823962776 0.7 5.2 5 2 decreased macrophage apoptosis 0.109256361998167 0.298326235423096 0.834625823962776 0.7 5.2 5 2 lethality during fetal growth through weaning, complete penetrance 0.109256361998167 0.298326235423096 0.834625823962776 0.7 5.2 5 2 decreased circulating lactate level 0.109256361998167 0.298326235423096 0.834625823962776 0.7 5.2 5 2 increased fatty acid oxidation 0.109256361998167 0.298326235423096 0.834625823962776 0.7 5.2 5 2 decreased heart rate 6.89247587554841e-07 1.65652499907504e-05 0.834625823962776 0.7 5.2 5 2 increased circulating chloride level 0.000422766228247653 0.00408403321792614 0.834625823962776 0.7 5.2 5 2 decreased hematocrit 2.55802195565002e-09 1.02630316365797e-07 0.832992505324884 0.698630136986301 5.2 5 2 seminiferous tubule degeneration 2.38995570229009e-05 0.000374032199709993 0.832992505324884 0.698630136986301 5.2 5 2 enlarged heart 6.57179236612878e-14 5.54146898669333e-12 0.832570095332326 0.698275862068966 5.2 5 2 azoospermia 5.54070034368176e-10 2.62523659141112e-08 0.832376158669076 0.69811320754717 5.2 5 2 abnormal male reproductive system morphology 0.00117923600644196 0.0100426241641873 0.831852980693797 0.697674418604651 5.2 5 2 delayed endochondral bone ossification 0.00117923600644196 0.0100426241641873 0.831852980693797 0.697674418604651 5.2 5 2 abnormal vascular development 6.52187989353107e-05 0.000901287568619919 0.831012725157743 0.696969696969697 5.2 5 2 abnormal tooth development 0.0044865386235227 0.0291771629438241 0.831012725157743 0.696969696969697 5.2 5 2 enlarged pericardium 0.0044865386235227 0.0291771629438241 0.831012725157743 0.696969696969697 5.2 5 2 belly spot 0.0044865386235227 0.0291771629438241 0.831012725157743 0.696969696969697 5.2 5 2 abnormal epidermis stratum basale morphology 0.0044865386235227 0.0291771629438241 0.831012725157743 0.696969696969697 5.2 5 2 single kidney 0.0044865386235227 0.0291771629438241 0.831012725157743 0.696969696969697 5.2 5 2 increased osteoblast cell number 0.0044865386235227 0.0291771629438241 0.831012725157743 0.696969696969697 5.2 5 2 myeloid hyperplasia 0.0044865386235227 0.0291771629438241 0.831012725157743 0.696969696969697 5.2 5 2 abnormal muscle physiology 3.80302395961797e-06 7.59841132493952e-05 0.830606758999874 0.696629213483146 5.2 5 2 abnormal inner ear morphology 0.000880573615871404 0.00783694765466947 0.829441812633815 0.695652173913043 5.2 5 2 fragile skeleton 0.0177475684974438 0.088117917439903 0.829441812633815 0.695652173913043 5.2 5 2 blistering 0.0177475684974438 0.088117917439903 0.829441812633815 0.695652173913043 5.2 5 2 dilated heart 0.0177475684974438 0.088117917439903 0.829441812633815 0.695652173913043 5.2 5 2 increased circulating HDL cholesterol level 6.12059031591984e-07 1.4926439618481e-05 0.828948097269152 0.695238095238095 5.2 5 2 decreased hemoglobin content 8.00145242031879e-09 2.94868339193229e-07 0.828706491877934 0.695035460992908 5.2 5 2 abnormal thoracic vertebrae morphology 0.000178703478702884 0.0019744035002372 0.828563166645855 0.694915254237288 5.2 5 2 narrow eye opening 0.003323960735388 0.0234563186646174 0.828001809486881 0.694444444444444 5.2 5 2 increased circulating insulin level 9.97202035761115e-10 4.27679321371685e-08 0.827173807677394 0.69375 5.2 5 2 prenatal lethality 0.00013421507869918 0.00159360385806305 0.826933420055285 0.693548387096774 5.2 5 2 delayed bone ossification 2.78822721043607e-05 0.000426813242212906 0.826677006591702 0.693333333333333 5.2 5 2 decreased bone resorption 0.0129655976782238 0.0674021404902441 0.825454111611537 0.692307692307692 5.2 5 2 absent teeth 0.0760847186082627 0.244365058151134 0.825454111611537 0.692307692307692 5.2 5 2 excessive scratching 0.0760847186082627 0.244365058151134 0.825454111611537 0.692307692307692 5.2 5 2 increased pituitary adenoma incidence 0.0760847186082627 0.244365058151134 0.825454111611537 0.692307692307692 5.2 5 2 abnormal intercostal muscle morphology 0.0760847186082627 0.244365058151134 0.825454111611537 0.692307692307692 5.2 5 2 abnormal bile duct development 0.0760847186082627 0.244365058151134 0.825454111611537 0.692307692307692 5.2 5 2 abnormal dopaminergic neuron morphology 0.0760847186082627 0.244365058151134 0.825454111611537 0.692307692307692 5.2 5 2 tracheoesophageal fistula 0.0760847186082627 0.244365058151134 0.825454111611537 0.692307692307692 5.2 5 2 muscle fatigue 0.0760847186082627 0.244365058151134 0.825454111611537 0.692307692307692 5.2 5 2 small otic vesicle 0.0760847186082627 0.244365058151134 0.825454111611537 0.692307692307692 5.2 5 2 decreased endocochlear potential 0.0760847186082627 0.244365058151134 0.825454111611537 0.692307692307692 5.2 5 2 decreased luteinizing hormone level 0.0760847186082627 0.244365058151134 0.825454111611537 0.692307692307692 5.2 5 2 increased circulating ammonia level 0.0760847186082627 0.244365058151134 0.825454111611537 0.692307692307692 5.2 5 2 hyperalgesia 0.0760847186082627 0.244365058151134 0.825454111611537 0.692307692307692 5.2 5 2 increased circulating thyroxine level 0.0760847186082627 0.244365058151134 0.825454111611537 0.692307692307692 5.2 5 2 increased rib number 2.10117392726361e-05 0.000340499683652653 0.825454111611537 0.692307692307692 5.2 5 2 abnormal circulating hormone level 0.00246664919829563 0.018396412484557 0.825454111611537 0.692307692307692 5.2 5 2 increased exploration in new environment 1.58369398678578e-05 0.000267989033478205 0.824321801444717 0.691358024691358 5.2 5 2 arrest of spermatogenesis 1.19386534653286e-05 0.00021136939854096 0.823270370575528 0.69047619047619 5.2 5 2 abnormal muscle morphology 0.00183312002695023 0.0146444403063394 0.823270370575528 0.69047619047619 5.2 5 2 abnormal spleen white pulp morphology 0.00183312002695023 0.0146444403063394 0.823270370575528 0.69047619047619 5.2 5 2 increased circulating free fatty acid level 5.6980215804208e-05 0.000794052026963403 0.822870530667526 0.690140845070423 5.2 5 2 enlarged liver 1.90816872696416e-06 4.14547572779332e-05 0.822702597906165 0.69 5.2 5 2 abnormal parietal bone morphology 0.00950739679601463 0.053749203477469 0.822291452180075 0.689655172413793 5.2 5 2 abnormal microglial cell morphology 0.00950739679601463 0.053749203477469 0.822291452180075 0.689655172413793 5.2 5 2 short sternum 0.00950739679601463 0.053749203477469 0.822291452180075 0.689655172413793 5.2 5 2 abnormal blood vessel morphology 1.0797949643864e-08 3.89273909262489e-07 0.822291452180075 0.689655172413793 5.2 5 2 abnormal intestine morphology 4.28534433719167e-05 0.000621562334621824 0.821735849847521 0.689189189189189 5.2 5 2 abnormal ovarian follicle morphology 0.00136408598247768 0.0113105462713774 0.821377795010986 0.688888888888889 5.2 5 2 increased or absent threshold for auditory brainstem response 9.77466455804394e-16 1.08064347058375e-13 0.821011067565954 0.688581314878893 5.2 5 2 abnormal long bone morphology 0.000206674263710361 0.00224009686701317 0.820943433406009 0.688524590163934 5.2 5 2 increased double-negative T cell number 0.000206674263710361 0.00224009686701317 0.820943433406009 0.688524590163934 5.2 5 2 lethargy 5.11968502470195e-06 0.000100277295267292 0.820523083465709 0.688172043010753 5.2 5 2 abnormal tooth morphology 0.000154950835047572 0.00179692401949107 0.819721791392012 0.6875 5.2 5 2 oligodactyly 0.00101625802713703 0.00888556007909794 0.819721791392012 0.6875 5.2 5 2 small heart 0.00101625802713703 0.00888556007909794 0.819721791392012 0.6875 5.2 5 2 abnormal diaphragm morphology 0.0069932647104342 0.0427413905828134 0.819721791392012 0.6875 5.2 5 2 abnormal heart atrium morphology 0.0069932647104342 0.0427413905828134 0.819721791392012 0.6875 5.2 5 2 abnormal tympanic ring morphology 0.0538430918753566 0.189440864271498 0.819721791392012 0.6875 5.2 5 2 abnormal hair follicle orientation 0.0538430918753566 0.189440864271498 0.819721791392012 0.6875 5.2 5 2 disorganized retinal layers 0.0538430918753566 0.189440864271498 0.819721791392012 0.6875 5.2 5 2 paternal imprinting 0.0538430918753566 0.189440864271498 0.819721791392012 0.6875 5.2 5 2 abnormal pulmonary elastic fiber morphology 0.0538430918753566 0.189440864271498 0.819721791392012 0.6875 5.2 5 2 decreased aggression towards mice 0.0538430918753566 0.189440864271498 0.819721791392012 0.6875 5.2 5 2 increased thymus weight 0.0538430918753566 0.189440864271498 0.819721791392012 0.6875 5.2 5 2 decreased circulating growth hormone level 0.0538430918753566 0.189440864271498 0.819721791392012 0.6875 5.2 5 2 decreased circulating prolactin level 0.0538430918753566 0.189440864271498 0.819721791392012 0.6875 5.2 5 2 decreased creatinine clearance 0.0538430918753566 0.189440864271498 0.819721791392012 0.6875 5.2 5 2 decreased skeletal muscle weight 0.0538430918753566 0.189440864271498 0.819721791392012 0.6875 5.2 5 2 abnormal liver morphology 3.35725193202763e-10 1.6215852778483e-08 0.819305477633053 0.687150837988827 5.2 5 2 increased total body fat amount 5.7718606769972e-08 1.77253128815192e-06 0.818609550155388 0.686567164179104 5.2 5 2 internal hemorrhage 0.000116232939337302 0.00140014255012851 0.818609550155388 0.686567164179104 5.2 5 2 abnormal dermal layer morphology 0.00515754118301789 0.0324563386720429 0.817592643881903 0.685714285714286 5.2 5 2 abnormal midbrain development 0.00515754118301789 0.0324563386720429 0.817592643881903 0.685714285714286 5.2 5 2 abnormal osteoblast physiology 0.000565815161859806 0.00530118725094639 0.816961785360389 0.685185185185185 5.2 5 2 decreased platelet aggregation 0.000565815161859806 0.00530118725094639 0.816961785360389 0.685185185185185 5.2 5 2 abnormal cardiovascular system physiology 8.75910142501232e-08 2.57380813227732e-06 0.815799677557601 0.684210526315789 5.2 5 2 absent vitelline blood vessels 0.00042276926778532 0.00408403321792614 0.815799677557601 0.684210526315789 5.2 5 2 abnormal facial morphology 0.00042276926778532 0.00408403321792614 0.815799677557601 0.684210526315789 5.2 5 2 decreased threshold for auditory brainstem response 0.00381231274561901 0.0264153982025829 0.815799677557601 0.684210526315789 5.2 5 2 small superior vagus ganglion 0.0385257577980082 0.154177544636462 0.815799677557601 0.684210526315789 5.2 5 2 shiny skin 0.0385257577980082 0.154177544636462 0.815799677557601 0.684210526315789 5.2 5 2 delayed sexual maturation 0.0385257577980082 0.154177544636462 0.815799677557601 0.684210526315789 5.2 5 2 increased malignant tumor incidence 0.0385257577980082 0.154177544636462 0.815799677557601 0.684210526315789 5.2 5 2 abnormal ear morphology 0.0385257577980082 0.154177544636462 0.815799677557601 0.684210526315789 5.2 5 2 abnormal neurotransmitter level 0.0385257577980082 0.154177544636462 0.815799677557601 0.684210526315789 5.2 5 2 abnormal metatarsal bone morphology 0.0385257577980082 0.154177544636462 0.815799677557601 0.684210526315789 5.2 5 2 oliguria 0.0385257577980082 0.154177544636462 0.815799677557601 0.684210526315789 5.2 5 2 absent amnion 0.0385257577980082 0.154177544636462 0.815799677557601 0.684210526315789 5.2 5 2 eyelids fail to open 0.0385257577980082 0.154177544636462 0.815799677557601 0.684210526315789 5.2 5 2 decreased fertilization frequency 0.0385257577980082 0.154177544636462 0.815799677557601 0.684210526315789 5.2 5 2 increased liver cholesterol level 0.0385257577980082 0.154177544636462 0.815799677557601 0.684210526315789 5.2 5 2 decreased circulating magnesium level 0.0385257577980082 0.154177544636462 0.815799677557601 0.684210526315789 5.2 5 2 shortened RR interval 0.0385257577980082 0.154177544636462 0.815799677557601 0.684210526315789 5.2 5 2 decreased birth weight 5.87808356764385e-06 0.00011161628148484 0.815799677557601 0.684210526315789 5.2 5 2 polydactyly 4.43004418755145e-06 8.75349678781908e-05 0.815159332441779 0.683673469387755 5.2 5 2 liver fibrosis 0.00282350134481795 0.0203283924608818 0.81426909654905 0.682926829268293 5.2 5 2 reduced male fertility 3.9672270243524e-12 2.86042818060191e-10 0.81414098624437 0.682819383259912 5.2 5 2 thrombocytopenia 2.8625802383123e-08 9.36930045105506e-07 0.814068537658274 0.682758620689655 5.2 5 2 increased blood urea nitrogen level 2.8625802383123e-08 9.36930045105506e-07 0.814068537658274 0.682758620689655 5.2 5 2 abnormal hair follicle morphology 0.000236583203546703 0.00252575415803615 0.81380749275282 0.682539682539683 5.2 5 2 respiratory failure 1.6370229342404e-08 5.65568687350417e-07 0.813306148232412 0.682119205298013 5.2 5 2 respiratory distress 1.53886689734636e-09 6.43349816327574e-08 0.813260505595438 0.682080924855491 5.2 5 2 increased circulating cholesterol level 1.1646403975621e-09 4.91024235412833e-08 0.812947231132574 0.681818181818182 5.2 5 2 small kidney 1.57234020169812e-05 0.000267890154227676 0.812947231132574 0.681818181818182 5.2 5 2 increased body size 0.0277894853276219 0.122891279559928 0.812947231132574 0.681818181818182 5.2 5 2 intestinal inflammation 0.0277894853276219 0.122891279559928 0.812947231132574 0.681818181818182 5.2 5 2 increased myocardial infarction size 0.0277894853276219 0.122891279559928 0.812947231132574 0.681818181818182 5.2 5 2 abnormal tracheal cartilage morphology 0.0277894853276219 0.122891279559928 0.812947231132574 0.681818181818182 5.2 5 2 abnormal cochlear sensory epithelium morphology 0.0277894853276219 0.122891279559928 0.812947231132574 0.681818181818182 5.2 5 2 decreased cardiac output 0.0277894853276219 0.122891279559928 0.812947231132574 0.681818181818182 5.2 5 2 abnormal basement membrane morphology 0.0277894853276219 0.122891279559928 0.812947231132574 0.681818181818182 5.2 5 2 abnormal blood-brain barrier function 0.0277894853276219 0.122891279559928 0.812947231132574 0.681818181818182 5.2 5 2 pulmonary vascular congestion 0.0277894853276219 0.122891279559928 0.812947231132574 0.681818181818182 5.2 5 2 abnormal rib morphology 1.00098456823174e-07 2.87855388841208e-06 0.812545775709793 0.681481481481481 5.2 5 2 microcephaly 0.000132755011053576 0.00158003870811374 0.81216177487061 0.681159420289855 5.2 5 2 hepatic necrosis 0.00155648236287542 0.0126734856878972 0.81179411449267 0.680851063829787 5.2 5 2 abnormal cell nucleus morphology 0.00155648236287542 0.0126734856878972 0.81179411449267 0.680851063829787 5.2 5 2 abnormal digit morphology 9.95344369056945e-05 0.00122267610766872 0.811441773297144 0.680555555555556 5.2 5 2 abnormal interventricular septum morphology 0.0011580858740564 0.010019960388575 0.810779371849554 0.68 5.2 5 2 abnormal hindlimb morphology 0.0011580858740564 0.010019960388575 0.810779371849554 0.68 5.2 5 2 abnormal inner ear vestibule morphology 0.0201697093970205 0.0936921608311642 0.810779371849554 0.68 5.2 5 2 diaphragmatic hernia 0.0201697093970205 0.0936921608311642 0.810779371849554 0.68 5.2 5 2 male infertility 1.74465556817929e-24 3.77376584856172e-22 0.810684554942543 0.679920477137177 5.2 5 2 abnormal heart morphology 5.16031904685878e-12 3.61585736029893e-10 0.810366446271836 0.67965367965368 5.2 5 2 abnormal heart ventricle morphology 5.60406865886795e-05 0.0007831528533109 0.810167924359471 0.67948717948718 5.2 5 2 abnormal jaw morphology 0.0147113090034403 0.0755301984438758 0.809076053841467 0.678571428571429 5.2 5 2 lymphoid hyperplasia 0.0147113090034403 0.0755301984438758 0.809076053841467 0.678571428571429 5.2 5 2 enhanced coordination 0.0147113090034403 0.0755301984438758 0.809076053841467 0.678571428571429 5.2 5 2 abnormal retinal pigmentation 2.37565879508634e-05 0.000374032199709993 0.80858659464374 0.67816091954023 5.2 5 2 abnormal bone mineralization 6.98533533883711e-07 1.67077131301513e-05 0.808020278216619 0.677685950413223 5.2 5 2 abnormal definitive hematopoiesis 1.34322325380292e-05 0.000232912850773385 0.807702410286558 0.67741935483871 5.2 5 2 abnormal nose morphology 0.0107730225483688 0.0584468780568535 0.807702410286558 0.67741935483871 5.2 5 2 inner cell mass degeneration 0.0107730225483688 0.0584468780568535 0.807702410286558 0.67741935483871 5.2 5 2 abnormal podocyte morphology 0.0107730225483688 0.0584468780568535 0.807702410286558 0.67741935483871 5.2 5 2 small cranium 0.0107730225483688 0.0584468780568535 0.807702410286558 0.67741935483871 5.2 5 2 cyanosis 4.93258128666863e-10 2.35957614434389e-08 0.807301764249709 0.677083333333333 5.2 5 2 retinal degeneration 1.01053636541556e-05 0.000181495249745213 0.807301764249709 0.677083333333333 5.2 5 2 decreased monocyte cell number 0.000268329201165547 0.0028222785957687 0.807110686909058 0.676923076923077 5.2 5 2 reduced female fertility 8.77985609678084e-12 5.90267352452495e-10 0.806873487451699 0.676724137931034 5.2 5 2 kinked tail 5.72477779671709e-06 0.000110044787875346 0.806571174417809 0.676470588235294 5.2 5 2 short maxilla 0.00791523044391364 0.047615805874813 0.806571174417809 0.676470588235294 5.2 5 2 abnormal retina morphology 9.24495374322754e-11 4.9455532121029e-09 0.806237190494654 0.676190476190476 5.2 5 2 abnormal branching of the mammary ductal tree 0.00583182351122738 0.0361311606081647 0.805623382203452 0.675675675675676 5.2 5 2 impaired skeletal muscle contractility 0.00583182351122738 0.0361311606081647 0.805623382203452 0.675675675675676 5.2 5 2 abnormal retinal pigment epithelium morphology 6.33714168966818e-05 0.000878197211869059 0.804817758821249 0.675 5.2 5 2 abnormal skin pigmentation 0.00430709279980529 0.0285703822387084 0.804817758821249 0.675 5.2 5 2 decreased oxygen consumption 0.00318759406943164 0.0226870965599749 0.804124548004004 0.674418604651163 5.2 5 2 abnormal myelin sheath morphology 0.00236334487346399 0.0178533652457256 0.803521755989008 0.673913043478261 5.2 5 2 no abnormal phenotype detected 1.72400765778391e-78 4.28846904873747e-75 0.803357421335929 0.673775216138329 5.2 5 2 abnormal T cell differentiation 8.57633819781633e-06 0.000156290412212953 0.80275185331639 0.673267326732673 5.2 5 2 abnormal snout morphology 0.00130512750011884 0.0108760625009903 0.802524830733439 0.673076923076923 5.2 5 2 abnormal platelet physiology 0.000971787321006726 0.00857206014540508 0.802107934717473 0.672727272727273 5.2 5 2 increased bone mineral density 2.75537790059338e-06 5.75966598968573e-05 0.801916088763224 0.672566371681416 5.2 5 2 decreased lymphocyte cell number 6.70101890722729e-07 1.61832859531339e-05 0.801091750678558 0.671875 5.2 5 2 decreased circulating LDL cholesterol level 0.000403735196187781 0.00395390275794136 0.801091750678558 0.671875 5.2 5 2 abnormal myocardium layer morphology 9.49120482514595e-05 0.00118342716804765 0.799912634177706 0.670886075949367 5.2 5 2 circling 5.34141713415969e-05 0.000757081203488446 0.799557512031567 0.670588235294118 5.2 5 2 abnormal neuron differentiation 4.10248541815155e-06 8.16394598212158e-05 0.798430316290921 0.669642857142857 5.2 5 2 decreased circulating cholesterol level 7.03962841974555e-09 2.61359338718165e-07 0.794881737107406 0.666666666666667 5.2 5 2 cochlear outer hair cell degeneration 0.000252032809569462 0.00267348236163769 0.794881737107406 0.666666666666667 5.2 5 2 abnormal food intake 0.000336886914310681 0.00341888144212693 0.794881737107406 0.666666666666667 5.2 5 2 abnormal limb bone morphology 0.00882470207827767 0.0514775725621223 0.794881737107406 0.666666666666667 5.2 5 2 short radius 0.00882470207827767 0.0514775725621223 0.794881737107406 0.666666666666667 5.2 5 2 abnormal trophoblast giant cell morphology 0.00882470207827767 0.0514775725621223 0.794881737107406 0.666666666666667 5.2 5 2 head tilt 0.00882470207827767 0.0514775725621223 0.794881737107406 0.666666666666667 5.2 5 2 lowered ear position 0.0597135432845062 0.207599495346204 0.794881737107406 0.666666666666667 5.2 5 2 abnormal megakaryocyte differentiation 0.0597135432845062 0.207599495346204 0.794881737107406 0.666666666666667 5.2 5 2 abnormal mammary gland morphology 0.0597135432845062 0.207599495346204 0.794881737107406 0.666666666666667 5.2 5 2 abnormal phrenic nerve morphology 0.0597135432845062 0.207599495346204 0.794881737107406 0.666666666666667 5.2 5 2 abnormal metacarpal bone morphology 0.0597135432845062 0.207599495346204 0.794881737107406 0.666666666666667 5.2 5 2 absent ureter 0.0597135432845062 0.207599495346204 0.794881737107406 0.666666666666667 5.2 5 2 long tibia 0.0597135432845062 0.207599495346204 0.794881737107406 0.666666666666667 5.2 5 2 abnormal pregnancy 0.0597135432845062 0.207599495346204 0.794881737107406 0.666666666666667 5.2 5 2 primary atelectasis 0.0597135432845062 0.207599495346204 0.794881737107406 0.666666666666667 5.2 5 2 abnormal metanephric mesenchyme morphology 0.0597135432845062 0.207599495346204 0.794881737107406 0.666666666666667 5.2 5 2 heart hyperplasia 0.175451125804837 0.421472405059906 0.794881737107406 0.666666666666667 5.2 5 2 renal tubular acidosis 0.175451125804837 0.421472405059906 0.794881737107406 0.666666666666667 5.2 5 2 abnormal cholinergic neuron morphology 0.175451125804837 0.421472405059906 0.794881737107406 0.666666666666667 5.2 5 2 dilated uterus 0.175451125804837 0.421472405059906 0.794881737107406 0.666666666666667 5.2 5 2 psoriasis 0.175451125804837 0.421472405059906 0.794881737107406 0.666666666666667 5.2 5 2 abnormal lens vesicle development 0.175451125804837 0.421472405059906 0.794881737107406 0.666666666666667 5.2 5 2 decreased level of surface class I molecules 0.175451125804837 0.421472405059906 0.794881737107406 0.666666666666667 5.2 5 2 abnormal germ cell morphology 0.175451125804837 0.421472405059906 0.794881737107406 0.666666666666667 5.2 5 2 abnormal laryngeal cartilage morphology 0.175451125804837 0.421472405059906 0.794881737107406 0.666666666666667 5.2 5 2 abnormal artery development 0.175451125804837 0.421472405059906 0.794881737107406 0.666666666666667 5.2 5 2 priapism 0.175451125804837 0.421472405059906 0.794881737107406 0.666666666666667 5.2 5 2 premature neuronal precursor differentiation 0.175451125804837 0.421472405059906 0.794881737107406 0.666666666666667 5.2 5 2 abnormal proprioceptive neuron morphology 0.175451125804837 0.421472405059906 0.794881737107406 0.666666666666667 5.2 5 2 decreased cochlear hair cell number 0.175451125804837 0.421472405059906 0.794881737107406 0.666666666666667 5.2 5 2 abnormal hair cell mechanoelectric transduction 0.175451125804837 0.421472405059906 0.794881737107406 0.666666666666667 5.2 5 2 abnormal gallbladder physiology 0.175451125804837 0.421472405059906 0.794881737107406 0.666666666666667 5.2 5 2 liver hyperplasia 0.175451125804837 0.421472405059906 0.794881737107406 0.666666666666667 5.2 5 2 abnormal oxygen consumption 0.175451125804837 0.421472405059906 0.794881737107406 0.666666666666667 5.2 5 2 positive geotaxis 0.175451125804837 0.421472405059906 0.794881737107406 0.666666666666667 5.2 5 2 abnormal leukopoiesis 0.175451125804837 0.421472405059906 0.794881737107406 0.666666666666667 5.2 5 2 decreased transitional stage T1 B cell number 0.175451125804837 0.421472405059906 0.794881737107406 0.666666666666667 5.2 5 2 abnormal ureteric bud invasion 0.175451125804837 0.421472405059906 0.794881737107406 0.666666666666667 5.2 5 2 decreased pancreatic beta cell proliferation 0.175451125804837 0.421472405059906 0.794881737107406 0.666666666666667 5.2 5 2 symmetric azygos veins 0.175451125804837 0.421472405059906 0.794881737107406 0.666666666666667 5.2 5 2 increased bone mineralization 0.175451125804837 0.421472405059906 0.794881737107406 0.666666666666667 5.2 5 2 enhanced leukocyte tethering or rolling 0.175451125804837 0.421472405059906 0.794881737107406 0.666666666666667 5.2 5 2 decreased platelet dense granule number 0.175451125804837 0.421472405059906 0.794881737107406 0.666666666666667 5.2 5 2 decreased insulin secretion 4.47659963608796e-05 0.000643672924553109 0.794881737107406 0.666666666666667 5.2 5 2 abnormal skin morphology 0.00045065516270287 0.0043365753084077 0.794881737107406 0.666666666666667 5.2 5 2 increased circulating aspartate transaminase level 0.000603349249608108 0.00564222277594049 0.794881737107406 0.666666666666667 5.2 5 2 decreased tumor growth/size 0.00145649251840251 0.0120566560383568 0.794881737107406 0.666666666666667 5.2 5 2 abnormal gluconeogenesis 0.00195839775637548 0.0151760573800125 0.794881737107406 0.666666666666667 5.2 5 2 cochlear inner hair cell degeneration 0.00195839775637548 0.0151760573800125 0.794881737107406 0.666666666666667 5.2 5 2 abnormal cardiovascular system morphology 0.00263693103435222 0.0190402494860701 0.794881737107406 0.666666666666667 5.2 5 2 abnormal osteoclast morphology 0.00263693103435222 0.0190402494860701 0.794881737107406 0.666666666666667 5.2 5 2 abnormal cell migration 0.00355612767942961 0.0247436856016256 0.794881737107406 0.666666666666667 5.2 5 2 small placenta 0.00355612767942961 0.0247436856016256 0.794881737107406 0.666666666666667 5.2 5 2 impaired macrophage chemotaxis 0.00650363984026576 0.0399945713291992 0.794881737107406 0.666666666666667 5.2 5 2 abnormal ovarian folliculogenesis 0.0120067168842572 0.0645069292647727 0.794881737107406 0.666666666666667 5.2 5 2 cardiovascular system phenotype 0.0120067168842572 0.0645069292647727 0.794881737107406 0.666666666666667 5.2 5 2 abnormal heart valve morphology 0.0224555145719554 0.102079841736788 0.794881737107406 0.666666666666667 5.2 5 2 abnormal skin appearance 0.0224555145719554 0.102079841736788 0.794881737107406 0.666666666666667 5.2 5 2 abnormal foregut morphology 0.0309126440939883 0.130996937280742 0.794881737107406 0.666666666666667 5.2 5 2 abnormal adrenal gland morphology 0.0309126440939883 0.130996937280742 0.794881737107406 0.666666666666667 5.2 5 2 decreased metastatic potential 0.0309126440939883 0.130996937280742 0.794881737107406 0.666666666666667 5.2 5 2 abnormal startle reflex 0.0309126440939883 0.130996937280742 0.794881737107406 0.666666666666667 5.2 5 2 abnormal vasodilation 0.0309126440939883 0.130996937280742 0.794881737107406 0.666666666666667 5.2 5 2 abnormal primitive streak formation 0.0309126440939883 0.130996937280742 0.794881737107406 0.666666666666667 5.2 5 2 small ears 0.0428036449349677 0.161167394232067 0.794881737107406 0.666666666666667 5.2 5 2 abnormal salivary gland morphology 0.0428036449349677 0.161167394232067 0.794881737107406 0.666666666666667 5.2 5 2 increased incidence of induced tumors 0.0428036449349677 0.161167394232067 0.794881737107406 0.666666666666667 5.2 5 2 decreased cochlear outer hair cell number 0.0428036449349677 0.161167394232067 0.794881737107406 0.666666666666667 5.2 5 2 abnormal tumor vascularization 0.0428036449349677 0.161167394232067 0.794881737107406 0.666666666666667 5.2 5 2 vascular ring 0.0428036449349677 0.161167394232067 0.794881737107406 0.666666666666667 5.2 5 2 decreased chondrocyte number 0.0841377968697841 0.267024827071749 0.794881737107406 0.666666666666667 5.2 5 2 no suckling reflex 0.0841377968697841 0.267024827071749 0.794881737107406 0.666666666666667 5.2 5 2 placental labyrinth hypoplasia 0.0841377968697841 0.267024827071749 0.794881737107406 0.666666666666667 5.2 5 2 abnormal cricoid cartilage morphology 0.0841377968697841 0.267024827071749 0.794881737107406 0.666666666666667 5.2 5 2 increased alcohol consumption 0.0841377968697841 0.267024827071749 0.794881737107406 0.666666666666667 5.2 5 2 abnormal glial cell morphology 0.0841377968697841 0.267024827071749 0.794881737107406 0.666666666666667 5.2 5 2 abnormal rostral migratory stream morphology 0.0841377968697841 0.267024827071749 0.794881737107406 0.666666666666667 5.2 5 2 abnormal trophectoderm morphology 0.0841377968697841 0.267024827071749 0.794881737107406 0.666666666666667 5.2 5 2 abnormal dendritic cell morphology 0.0841377968697841 0.267024827071749 0.794881737107406 0.666666666666667 5.2 5 2 herniated liver 0.0841377968697841 0.267024827071749 0.794881737107406 0.666666666666667 5.2 5 2 abnormal esophagus morphology 0.120220759538722 0.321212824224028 0.794881737107406 0.666666666666667 5.2 5 2 abnormal rectum morphology 0.120220759538722 0.321212824224028 0.794881737107406 0.666666666666667 5.2 5 2 decreased digestive secretion 0.120220759538722 0.321212824224028 0.794881737107406 0.666666666666667 5.2 5 2 mesocardia 0.120220759538722 0.321212824224028 0.794881737107406 0.666666666666667 5.2 5 2 impaired embryo implantation 0.120220759538722 0.321212824224028 0.794881737107406 0.666666666666667 5.2 5 2 altered tumor susceptibility 0.120220759538722 0.321212824224028 0.794881737107406 0.666666666666667 5.2 5 2 abnormal tracheal ciliated epithelium morphology 0.120220759538722 0.321212824224028 0.794881737107406 0.666666666666667 5.2 5 2 increased circulating parathyroid hormone level 0.120220759538722 0.321212824224028 0.794881737107406 0.666666666666667 5.2 5 2 abnormal aorta elastic fiber morphology 0.120220759538722 0.321212824224028 0.794881737107406 0.666666666666667 5.2 5 2 small intestinal inflammation 0.120220759538722 0.321212824224028 0.794881737107406 0.666666666666667 5.2 5 2 delayed somite formation 0.120220759538722 0.321212824224028 0.794881737107406 0.666666666666667 5.2 5 2 abnormal defecation 0.120220759538722 0.321212824224028 0.794881737107406 0.666666666666667 5.2 5 2 increased hepatocyte proliferation 0.120220759538722 0.321212824224028 0.794881737107406 0.666666666666667 5.2 5 2 bowed ulna 0.120220759538722 0.321212824224028 0.794881737107406 0.666666666666667 5.2 5 2 stria vascularis degeneration 0.120220759538722 0.321212824224028 0.794881737107406 0.666666666666667 5.2 5 2 decreased cochlear nerve compound action potential 0.120220759538722 0.321212824224028 0.794881737107406 0.666666666666667 5.2 5 2 abnormal palatine bone morphology 0.120220759538722 0.321212824224028 0.794881737107406 0.666666666666667 5.2 5 2 abnormal patella morphology 0.120220759538722 0.321212824224028 0.794881737107406 0.666666666666667 5.2 5 2 reduced cerebellar foliation 0.120220759538722 0.321212824224028 0.794881737107406 0.666666666666667 5.2 5 2 increased fibrosarcoma incidence 0.120220759538722 0.321212824224028 0.794881737107406 0.666666666666667 5.2 5 2 increased skeletal muscle glycogen level 0.120220759538722 0.321212824224028 0.794881737107406 0.666666666666667 5.2 5 2 increased type II pneumocyte number 0.120220759538722 0.321212824224028 0.794881737107406 0.666666666666667 5.2 5 2 increased body weight 2.06161708958507e-10 1.01549950699858e-08 0.793107447515648 0.665178571428571 5.2 5 2 increased sensitivity to xenobiotic induced morbidity/mortality 8.98201982738009e-06 0.000162492904149876 0.791268638302372 0.663636363636364 5.2 5 2 abnormal angiogenesis 0.000279479111765383 0.00291490268560332 0.789510914559383 0.662162162162162 5.2 5 2 small seminiferous tubules 0.000279479111765383 0.00291490268560332 0.789510914559383 0.662162162162162 5.2 5 2 increased circulating triglyceride level 4.43564174277932e-07 1.10891043569483e-05 0.789399794092872 0.662068965517241 5.2 5 2 atelectasis 0.000373462122449589 0.00372339490818979 0.789283978395382 0.661971830985915 5.2 5 2 corneal opacity 0.000373462122449589 0.00372339490818979 0.789283978395382 0.661971830985915 5.2 5 2 increased heart weight 7.79358491209773e-07 1.83965178279553e-05 0.789163163459151 0.661870503597122 5.2 5 2 abnormal skeleton morphology 7.4840339519883e-06 0.000138929361608738 0.787969722002124 0.660869565217391 5.2 5 2 extramedullary hematopoiesis 1.7549414544852e-05 0.000292980997854492 0.787382852795072 0.660377358490566 5.2 5 2 increased circulating bilirubin level 0.00216538838971519 0.0165480909966714 0.787382852795072 0.660377358490566 5.2 5 2 abnormal liver physiology 3.10231996640635e-05 0.000473436866039005 0.786932919736332 0.66 5.2 5 2 short stride length 0.00291378593892763 0.0208277083996623 0.786932919736332 0.66 5.2 5 2 decreased circulating alkaline phosphatase level 0.00291378593892763 0.0208277083996623 0.786932919736332 0.66 5.2 5 2 cleft secondary palate 5.49204603827241e-05 0.000771834153683764 0.786425548414774 0.659574468085106 5.2 5 2 decreased bone trabecula number 0.00392664098772937 0.0270568406010438 0.786425548414774 0.659574468085106 5.2 5 2 thymus hypoplasia 1.14137193169779e-06 2.58105698190749e-05 0.786241718225804 0.659420289855073 5.2 5 2 abnormal glucose homeostasis 2.46602168432391e-08 8.23386434866541e-07 0.786146772963368 0.659340659340659 5.2 5 2 small ovary 7.31170939118365e-05 0.000975221292791921 0.786146772963368 0.659340659340659 5.2 5 2 increased thermal nociceptive threshold 7.31170939118365e-05 0.000975221292791921 0.786146772963368 0.659340659340659 5.2 5 2 hyperglycemia 9.73854719230687e-05 0.00119923941291403 0.785848990094822 0.659090909090909 5.2 5 2 short femur 9.73854719230687e-05 0.00119923941291403 0.785848990094822 0.659090909090909 5.2 5 2 teratozoospermia 9.73854719230687e-05 0.00119923941291403 0.785848990094822 0.659090909090909 5.2 5 2 abnormal myelopoiesis 0.00530039394395141 0.0332109066387383 0.785848990094822 0.659090909090909 5.2 5 2 abnormal astrocyte morphology 0.00530039394395141 0.0332109066387383 0.785848990094822 0.659090909090909 5.2 5 2 decreased sensitivity to induced morbidity/mortality 0.00530039394395141 0.0332109066387383 0.785848990094822 0.659090909090909 5.2 5 2 decreased B cell proliferation 0.000230786031581499 0.00246916238089883 0.784819942966806 0.658227848101266 5.2 5 2 abnormal compact bone morphology 0.00971549806047432 0.0546771525462214 0.784422766882308 0.657894736842105 5.2 5 2 abnormal kidney morphology 6.29303657136848e-08 1.90901566722916e-06 0.783526283720157 0.657142857142857 5.2 5 2 thick pulmonary interalveolar septum 0.0132008015272971 0.0681972872256523 0.783526283720157 0.657142857142857 5.2 5 2 ovary cysts 0.0132008015272971 0.0681972872256523 0.783526283720157 0.657142857142857 5.2 5 2 abnormal artery morphology 0.0132008015272971 0.0681972872256523 0.783526283720157 0.657142857142857 5.2 5 2 decreased glycogen level 0.0132008015272971 0.0681972872256523 0.783526283720157 0.657142857142857 5.2 5 2 decreased circulating thyroxine level 0.0132008015272971 0.0681972872256523 0.783526283720157 0.657142857142857 5.2 5 2 decreased bone mineralization 0.0132008015272971 0.0681972872256523 0.783526283720157 0.657142857142857 5.2 5 2 enlarged spleen 5.26567186840542e-12 3.63843299240513e-10 0.782461709965103 0.65625 5.2 5 2 neonatal lethality 0.0179889238753348 0.0890496480395927 0.782461709965103 0.65625 5.2 5 2 abnormal lumbar vertebrae morphology 0.0179889238753348 0.0890496480395927 0.782461709965103 0.65625 5.2 5 2 abnormal embryonic hematopoiesis 0.0179889238753348 0.0890496480395927 0.782461709965103 0.65625 5.2 5 2 decreased circulating glucose level 1.21406090323221e-11 7.94730657050035e-10 0.782061063928254 0.655913978494624 5.2 5 2 cochlear ganglion degeneration 0.00176887741204552 0.0143558974305489 0.781176879571071 0.655172413793103 5.2 5 2 aphagia 0.0245987421975491 0.110151883377864 0.781176879571071 0.655172413793103 5.2 5 2 decreased cardiac muscle contractility 3.74273996041622e-05 0.00055089145867073 0.779595549855341 0.653846153846154 5.2 5 2 absent corpus luteum 0.00319235268486027 0.0226885065816855 0.779595549855341 0.653846153846154 5.2 5 2 ventricular hypoplasia 0.0337774759769694 0.141450288708268 0.779595549855341 0.653846153846154 5.2 5 2 thick skin 0.0337774759769694 0.141450288708268 0.779595549855341 0.653846153846154 5.2 5 2 abnormal ocular fundus morphology 0.0337774759769694 0.141450288708268 0.779595549855341 0.653846153846154 5.2 5 2 abnormal erythrocyte osmotic lysis 0.0337774759769694 0.141450288708268 0.779595549855341 0.653846153846154 5.2 5 2 abnormal pulmonary alveolus morphology 4.97422999271524e-05 0.000709077198101957 0.779141504689437 0.653465346534653 5.2 5 2 cardiac hypertrophy 6.61307427037091e-05 0.000911358573271338 0.778659660839908 0.653061224489796 5.2 5 2 absent kidney 0.00429699152986203 0.0285414323912732 0.778659660839908 0.653061224489796 5.2 5 2 increased fluid intake 0.00429699152986203 0.0285414323912732 0.778659660839908 0.653061224489796 5.2 5 2 abnormal retinal cone cell morphology 0.0466180793842059 0.171836433384144 0.777601699344202 0.652173913043478 5.2 5 2 abnormal cranial nerve morphology 0.0466180793842059 0.171836433384144 0.777601699344202 0.652173913043478 5.2 5 2 abnormal lens development 0.0466180793842059 0.171836433384144 0.777601699344202 0.652173913043478 5.2 5 2 abnormal long bone epiphyseal plate morphology 0.00192837675101064 0.0150607132437644 0.775009693679721 0.65 5.2 5 2 head bobbing 0.0105829414868352 0.0577304099747862 0.775009693679721 0.65 5.2 5 2 abnormal cell proliferation 0.0647524215629498 0.222782363261186 0.775009693679721 0.65 5.2 5 2 increased urine glucose level 0.0647524215629498 0.222782363261186 0.775009693679721 0.65 5.2 5 2 brain inflammation 0.0647524215629498 0.222782363261186 0.775009693679721 0.65 5.2 5 2 absent placental labyrinth 0.0647524215629498 0.222782363261186 0.775009693679721 0.65 5.2 5 2 abnormal male reproductive system physiology 0.0647524215629498 0.222782363261186 0.775009693679721 0.65 5.2 5 2 abnormal heart right ventricle morphology 0.0647524215629498 0.222782363261186 0.775009693679721 0.65 5.2 5 2 abnormal induced retinal neovascularization 0.0647524215629498 0.222782363261186 0.775009693679721 0.65 5.2 5 2 enhanced behavioral response to xenobiotic 0.0647524215629498 0.222782363261186 0.775009693679721 0.65 5.2 5 2 decreased muscle cell glucose uptake 0.0647524215629498 0.222782363261186 0.775009693679721 0.65 5.2 5 2 abnormal pancreatic beta cell physiology 0.014350016355909 0.0739040697418707 0.773398446915314 0.648648648648649 5.2 5 2 abnormal chromosome morphology 0.014350016355909 0.0739040697418707 0.773398446915314 0.648648648648649 5.2 5 2 decreased circulating HDL cholesterol level 8.88698273992233e-06 0.000161360361792385 0.773146689608375 0.6484375 5.2 5 2 abnormal B cell differentiation 0.000169452029013582 0.00193798584906338 0.773044326747312 0.648351648351648 5.2 5 2 diluted coat color 0.00347124920529121 0.0242208482416883 0.772801688854422 0.648148148148148 5.2 5 2 polyphagia 0.00347124920529121 0.0242208482416883 0.772801688854422 0.648148148148148 5.2 5 2 abnormal long bone epiphyseal plate proliferative zone 0.00347124920529121 0.0242208482416883 0.772801688854422 0.648148148148148 5.2 5 2 increased kidney weight 0.00466533094027324 0.0302213820675252 0.7715028624866 0.647058823529412 5.2 5 2 overexpanded pulmonary alveoli 0.0195077753582204 0.0918629541196593 0.7715028624866 0.647058823529412 5.2 5 2 abnormal brown adipose tissue morphology 0.0195077753582204 0.0918629541196593 0.7715028624866 0.647058823529412 5.2 5 2 distended urinary bladder 0.0906861037926096 0.267024827071749 0.7715028624866 0.647058823529412 5.2 5 2 abnormal vagus nerve morphology 0.0906861037926096 0.267024827071749 0.7715028624866 0.647058823529412 5.2 5 2 increased incidence of corneal inflammation 0.0906861037926096 0.267024827071749 0.7715028624866 0.647058823529412 5.2 5 2 abnormal touch/ nociception 0.0906861037926096 0.267024827071749 0.7715028624866 0.647058823529412 5.2 5 2 abnormal duodenum morphology 0.0906861037926096 0.267024827071749 0.7715028624866 0.647058823529412 5.2 5 2 aminoaciduria 0.0906861037926096 0.267024827071749 0.7715028624866 0.647058823529412 5.2 5 2 abnormal melanosome morphology 0.0906861037926096 0.267024827071749 0.7715028624866 0.647058823529412 5.2 5 2 decreased growth hormone level 0.0906861037926096 0.267024827071749 0.7715028624866 0.647058823529412 5.2 5 2 abnormal circulating chemokine level 0.0906861037926096 0.267024827071749 0.7715028624866 0.647058823529412 5.2 5 2 common atrium 0.0906861037926096 0.267024827071749 0.7715028624866 0.647058823529412 5.2 5 2 abnormal electroretinogram waveform feature 0.0906861037926096 0.267024827071749 0.7715028624866 0.647058823529412 5.2 5 2 decreased T cell number 9.1330922054521e-07 2.10400735092522e-05 0.770195968874257 0.645962732919255 5.2 5 2 thymus atrophy 0.00627846502035825 0.0387055309495444 0.7700416828228 0.645833333333333 5.2 5 2 hunched posture 0.000532206758821529 0.00506257863314935 0.769727251755906 0.645569620253165 5.2 5 2 decreased thymus weight 0.026598604512576 0.118573528181062 0.769240390749103 0.645161290322581 5.2 5 2 decreased neuronal precursor cell number 0.026598604512576 0.118573528181062 0.769240390749103 0.645161290322581 5.2 5 2 abnormal mitochondrial ATP synthesis coupled electron transport 0.026598604512576 0.118573528181062 0.769240390749103 0.645161290322581 5.2 5 2 abnormal cartilage development 0.00846187654839716 0.0504165698542226 0.768385679203826 0.644444444444444 5.2 5 2 abnormal metabolism 0.00846187654839716 0.0504165698542226 0.768385679203826 0.644444444444444 5.2 5 2 increased hemoglobin content 0.00279741991994561 0.0201698030459846 0.767936593476646 0.644067796610169 5.2 5 2 hydronephrosis 0.00043166814138906 0.0041619166732763 0.766493103639284 0.642857142857143 5.2 5 2 dehydration 0.00126194201235374 0.0106229467198982 0.766493103639284 0.642857142857143 5.2 5 2 short mandible 0.00374925804957207 0.02601472635512 0.766493103639284 0.642857142857143 5.2 5 2 abnormal seminal vesicle morphology 0.00374925804957207 0.02601472635512 0.766493103639284 0.642857142857143 5.2 5 2 abnormal cartilage morphology 0.0114235785313901 0.0615734595814363 0.766493103639284 0.642857142857143 5.2 5 2 abnormal ovulation 0.0363950845952824 0.15190062572276 0.766493103639284 0.642857142857143 5.2 5 2 abnormal renal tubule epithelium morphology 0.0363950845952824 0.15190062572276 0.766493103639284 0.642857142857143 5.2 5 2 abnormal pinna reflex 0.128421152906256 0.341655206261295 0.766493103639284 0.642857142857143 5.2 5 2 extended life span 0.128421152906256 0.341655206261295 0.766493103639284 0.642857142857143 5.2 5 2 abnormal endplate potential 0.128421152906256 0.341655206261295 0.766493103639284 0.642857142857143 5.2 5 2 absent otoliths 0.128421152906256 0.341655206261295 0.766493103639284 0.642857142857143 5.2 5 2 intestinal obstruction 0.128421152906256 0.341655206261295 0.766493103639284 0.642857142857143 5.2 5 2 abnormal positive T cell selection 0.128421152906256 0.341655206261295 0.766493103639284 0.642857142857143 5.2 5 2 abnormal glucose tolerance 0.128421152906256 0.341655206261295 0.766493103639284 0.642857142857143 5.2 5 2 decreased response to antigen 0.128421152906256 0.341655206261295 0.766493103639284 0.642857142857143 5.2 5 2 abnormal vertebrae morphology 6.90043444434639e-05 0.000940538667414337 0.765711765103464 0.642201834862385 5.2 5 2 increased circulating alanine transaminase level 0.000764617373627007 0.00692890971547243 0.764309362603275 0.641025641025641 5.2 5 2 decreased trabecular bone volume 0.0154509591679896 0.078920453655799 0.764309362603275 0.641025641025641 5.2 5 2 abnormal lens morphology 1.96848293698688e-05 0.000324278232169195 0.763831669251648 0.640625 5.2 5 2 testicular atrophy 0.00675602369152322 0.0414953306979358 0.76308646762311 0.64 5.2 5 2 mandible hypoplasia 0.0500111946663755 0.181875506919019 0.76308646762311 0.64 5.2 5 2 spontaneous skin ulceration 0.0500111946663755 0.181875506919019 0.76308646762311 0.64 5.2 5 2 decreased placenta weight 0.0500111946663755 0.181875506919019 0.76308646762311 0.64 5.2 5 2 abnormal energy expenditure 0.0500111946663755 0.181875506919019 0.76308646762311 0.64 5.2 5 2 impaired conditioned place preference behavior 0.0500111946663755 0.181875506919019 0.76308646762311 0.64 5.2 5 2 abnormal preimplantation embryo development 0.0500111946663755 0.181875506919019 0.76308646762311 0.64 5.2 5 2 increased oxygen consumption 0.000464502140008708 0.00446119333309522 0.762531898969314 0.63953488372093 5.2 5 2 abnormal uterus morphology 0.0209431313217162 0.0959411402629266 0.761761664727931 0.638888888888889 5.2 5 2 abnormal reflex 0.0209431313217162 0.0959411402629266 0.761761664727931 0.638888888888889 5.2 5 2 renal hypoplasia 0.0209431313217162 0.0959411402629266 0.761761664727931 0.638888888888889 5.2 5 2 abnormal T-helper 1 physiology 0.00908545623982523 0.0518350284324891 0.761056982336878 0.638297872340426 5.2 5 2 decreased litter size 7.0471179796713e-10 3.2462418471171e-08 0.759522229228963 0.637010676156584 5.2 5 2 abnormal tail morphology 0.0024121799138525 0.0181004450549264 0.758750749057069 0.636363636363636 5.2 5 2 dilated heart atrium 0.0284577861097204 0.124628068570298 0.758750749057069 0.636363636363636 5.2 5 2 increased T cell number 0.000497939960828646 0.00474569215540712 0.758750749057069 0.636363636363636 5.2 5 2 osteoporosis 0.0122349420883656 0.065450362246902 0.758750749057069 0.636363636363636 5.2 5 2 abnormal gametogenesis 0.0122349420883656 0.065450362246902 0.758750749057069 0.636363636363636 5.2 5 2 cochlear hair cell degeneration 0.0122349420883656 0.065450362246902 0.758750749057069 0.636363636363636 5.2 5 2 abnormal amino acid level 0.0122349420883656 0.065450362246902 0.758750749057069 0.636363636363636 5.2 5 2 abnormal abdominal fat pad morphology 0.0690784242478229 0.232835474683549 0.758750749057069 0.636363636363636 5.2 5 2 abnormal long bone epiphysis morphology 0.0690784242478229 0.232835474683549 0.758750749057069 0.636363636363636 5.2 5 2 testis hypoplasia 0.0690784242478229 0.232835474683549 0.758750749057069 0.636363636363636 5.2 5 2 abnormal chorion morphology 0.0690784242478229 0.232835474683549 0.758750749057069 0.636363636363636 5.2 5 2 decreased circulating estradiol level 0.0690784242478229 0.232835474683549 0.758750749057069 0.636363636363636 5.2 5 2 abnormal sebaceous gland morphology 0.184734085546081 0.432178719593789 0.758750749057069 0.636363636363636 5.2 5 2 abnormal enteric ganglia morphology 0.184734085546081 0.432178719593789 0.758750749057069 0.636363636363636 5.2 5 2 abnormal vestibular ganglion morphology 0.184734085546081 0.432178719593789 0.758750749057069 0.636363636363636 5.2 5 2 decreased post-tetanic potentiation 0.184734085546081 0.432178719593789 0.758750749057069 0.636363636363636 5.2 5 2 patent ductus arteriosus 0.184734085546081 0.432178719593789 0.758750749057069 0.636363636363636 5.2 5 2 abnormal frequency of paradoxical sleep 0.184734085546081 0.432178719593789 0.758750749057069 0.636363636363636 5.2 5 2 pulmonary hypertension 0.184734085546081 0.432178719593789 0.758750749057069 0.636363636363636 5.2 5 2 abnormal crista ampullaris neuroepithelium morphology 0.184734085546081 0.432178719593789 0.758750749057069 0.636363636363636 5.2 5 2 abnormal platelet aggregation 0.184734085546081 0.432178719593789 0.758750749057069 0.636363636363636 5.2 5 2 shortened PR interval 0.184734085546081 0.432178719593789 0.758750749057069 0.636363636363636 5.2 5 2 decreased core body temperature 0.184734085546081 0.432178719593789 0.758750749057069 0.636363636363636 5.2 5 2 abnormal brain ependyma motile cilium morphology 0.184734085546081 0.432178719593789 0.758750749057069 0.636363636363636 5.2 5 2 abnormal phrenic nerve innervation pattern to diaphragm 0.184734085546081 0.432178719593789 0.758750749057069 0.636363636363636 5.2 5 2 polyuria 0.00109151633338706 0.00952683115543967 0.758750749057069 0.636363636363636 5.2 5 2 decreased susceptibility to hepatic steatosis 0.00321906838803724 0.0228457421262272 0.757030225816577 0.634920634920635 5.2 5 2 cachexia 0.000184579683220671 0.00201820642642382 0.756666268977242 0.634615384615385 5.2 5 2 Leydig cell hyperplasia 0.0165016449186342 0.0831769842656587 0.756107018224118 0.634146341463415 5.2 5 2 abnormal hair cycle 0.0387799804463699 0.154177544636462 0.755137650252036 0.633333333333333 5.2 5 2 emphysema 0.0387799804463699 0.154177544636462 0.755137650252036 0.633333333333333 5.2 5 2 abnormal cellular respiration 0.0387799804463699 0.154177544636462 0.755137650252036 0.633333333333333 5.2 5 2 abnormal visceral yolk sac morphology 0.00116532533018816 0.0100426241641873 0.754634560545006 0.632911392405063 5.2 5 2 organ of Corti degeneration 0.00969100269843499 0.0546010627686456 0.754326546438661 0.63265306122449 5.2 5 2 increased circulating LDL cholesterol level 0.00969100269843499 0.0546010627686456 0.754326546438661 0.63265306122449 5.2 5 2 abnormal spleen morphology 2.13503250576995e-06 4.55870674515258e-05 0.753767164498402 0.632183908045977 5.2 5 2 short limbs 0.000705075826340011 0.00641270975510339 0.753767164498402 0.632183908045977 5.2 5 2 increased macrophage cell number 0.00574364907720047 0.035673725541913 0.753045856207016 0.631578947368421 5.2 5 2 decreased hair follicle number 0.0222949048623684 0.101665583584127 0.753045856207016 0.631578947368421 5.2 5 2 flaky skin 0.09603546126136 0.269321544405449 0.753045856207016 0.631578947368421 5.2 5 2 thin dermal layer 0.09603546126136 0.269321544405449 0.753045856207016 0.631578947368421 5.2 5 2 short vibrissae 0.09603546126136 0.269321544405449 0.753045856207016 0.631578947368421 5.2 5 2 decreased grooming behavior 0.09603546126136 0.269321544405449 0.753045856207016 0.631578947368421 5.2 5 2 increased susceptibility to ischemic brain injury 0.09603546126136 0.269321544405449 0.753045856207016 0.631578947368421 5.2 5 2 increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 0.09603546126136 0.269321544405449 0.753045856207016 0.631578947368421 5.2 5 2 abnormal enzyme/coenzyme activity 7.89415763100817e-06 0.000144920421454855 0.751846738601591 0.630573248407643 5.2 5 2 abnormal lung morphology 9.68728879619041e-05 0.00119923941291403 0.751463827097338 0.630252100840336 5.2 5 2 increased monocyte cell number 0.000344006703908472 0.00345047046763034 0.751163241566499 0.63 5.2 5 2 abnormal palate morphology 0.0530248103654932 0.189440864271498 0.750721640601439 0.62962962962963 5.2 5 2 abnormal bone trabecula morphology 0.0530248103654932 0.189440864271498 0.750721640601439 0.62962962962963 5.2 5 2 increased circulating serum albumin level 0.030181115687475 0.128553981631154 0.749459923558411 0.628571428571429 5.2 5 2 increased red blood cell distribution width 0.030181115687475 0.128553981631154 0.749459923558411 0.628571428571429 5.2 5 2 impaired adaptive thermogenesis 0.030181115687475 0.128553981631154 0.749459923558411 0.628571428571429 5.2 5 2 abnormal organ of Corti morphology 0.0175011616158933 0.0871554344735426 0.748667682624417 0.627906976744186 5.2 5 2 abnormal homeostasis 0.0175011616158933 0.0871554344735426 0.748667682624417 0.627906976744186 5.2 5 2 female infertility 1.19764520361642e-08 4.19597527323359e-07 0.74856344039626 0.62781954887218 5.2 5 2 increased leukocyte cell number 2.36141949187126e-05 0.000374032199709993 0.748285221483868 0.627586206896552 5.2 5 2 impaired hematopoiesis 0.0102771904304706 0.0561240640961482 0.748123987865794 0.627450980392157 5.2 5 2 increased lung adenocarcinoma incidence 0.0102771904304706 0.0561240640961482 0.748123987865794 0.627450980392157 5.2 5 2 spleen hyperplasia 0.00218046489123813 0.0165734950953157 0.747188832880962 0.626666666666667 5.2 5 2 deafness 0.000481923478473893 0.00460186047103189 0.746707086373624 0.626262626262626 5.2 5 2 increased T cell proliferation 0.00029303153832809 0.00304985753803818 0.746594528778451 0.626168224299065 5.2 5 2 perinatal lethality 0.0235643219699136 0.106092761810244 0.745201628538193 0.625 5.2 5 2 abnormal pancreatic beta cell morphology 0.0235643219699136 0.106092761810244 0.745201628538193 0.625 5.2 5 2 polydipsia 0.0409480722413113 0.161167394232067 0.745201628538193 0.625 5.2 5 2 increased fatty acid level 0.0409480722413113 0.161167394232067 0.745201628538193 0.625 5.2 5 2 abnormal malleus morphology 0.0727938048679018 0.238278895680537 0.745201628538193 0.625 5.2 5 2 increased stereotypic behavior 0.0727938048679018 0.238278895680537 0.745201628538193 0.625 5.2 5 2 apnea 0.0727938048679018 0.238278895680537 0.745201628538193 0.625 5.2 5 2 prolonged QT interval 0.0727938048679018 0.238278895680537 0.745201628538193 0.625 5.2 5 2 decreased fatty acid level 0.0727938048679018 0.238278895680537 0.745201628538193 0.625 5.2 5 2 absent mandible 0.134628971860497 0.350842586790429 0.745201628538193 0.625 5.2 5 2 abnormal pituitary gland morphology 0.134628971860497 0.350842586790429 0.745201628538193 0.625 5.2 5 2 disorganized yolk sac vascular plexus 0.134628971860497 0.350842586790429 0.745201628538193 0.625 5.2 5 2 abnormal extraembryonic endoderm formation 0.134628971860497 0.350842586790429 0.745201628538193 0.625 5.2 5 2 abnormal meiosis 0.134628971860497 0.350842586790429 0.745201628538193 0.625 5.2 5 2 white spotting 0.134628971860497 0.350842586790429 0.745201628538193 0.625 5.2 5 2 decreased cochlear coiling 0.134628971860497 0.350842586790429 0.745201628538193 0.625 5.2 5 2 abnormal molar crown morphology 0.134628971860497 0.350842586790429 0.745201628538193 0.625 5.2 5 2 bowed tibia 0.134628971860497 0.350842586790429 0.745201628538193 0.625 5.2 5 2 abnormal epididymis epithelium morphology 0.134628971860497 0.350842586790429 0.745201628538193 0.625 5.2 5 2 kidney degeneration 0.134628971860497 0.350842586790429 0.745201628538193 0.625 5.2 5 2 decreased liver cholesterol level 0.134628971860497 0.350842586790429 0.745201628538193 0.625 5.2 5 2 abnormal thoracic cage shape 0.134628971860497 0.350842586790429 0.745201628538193 0.625 5.2 5 2 increased heart left ventricle size 0.134628971860497 0.350842586790429 0.745201628538193 0.625 5.2 5 2 dilated respiratory conducting tubes 0.134628971860497 0.350842586790429 0.745201628538193 0.625 5.2 5 2 decreased adipocyte glucose uptake 0.134628971860497 0.350842586790429 0.745201628538193 0.625 5.2 5 2 abnormal ear pigmentation 0.272203573259024 0.505686397351443 0.745201628538193 0.625 5.2 5 2 absent pre-B cells 0.272203573259024 0.505686397351443 0.745201628538193 0.625 5.2 5 2 failure of vascular branching 0.272203573259024 0.505686397351443 0.745201628538193 0.625 5.2 5 2 schistocytosis 0.272203573259024 0.505686397351443 0.745201628538193 0.625 5.2 5 2 abnormal cecum morphology 0.272203573259024 0.505686397351443 0.745201628538193 0.625 5.2 5 2 absent skin pigmentation 0.272203573259024 0.505686397351443 0.745201628538193 0.625 5.2 5 2 dry eyes 0.272203573259024 0.505686397351443 0.745201628538193 0.625 5.2 5 2 spinning 0.272203573259024 0.505686397351443 0.745201628538193 0.625 5.2 5 2 abnormal urination 0.272203573259024 0.505686397351443 0.745201628538193 0.625 5.2 5 2 abnormal cellular cholesterol metabolism 0.272203573259024 0.505686397351443 0.745201628538193 0.625 5.2 5 2 calcified muscle 0.272203573259024 0.505686397351443 0.745201628538193 0.625 5.2 5 2 pulmonary interstitial fibrosis 0.272203573259024 0.505686397351443 0.745201628538193 0.625 5.2 5 2 increased left ventricle systolic pressure 0.272203573259024 0.505686397351443 0.745201628538193 0.625 5.2 5 2 abnormal forelimb zeugopod morphology 0.272203573259024 0.505686397351443 0.745201628538193 0.625 5.2 5 2 abnormal hair follicle melanocyte morphology 0.272203573259024 0.505686397351443 0.745201628538193 0.625 5.2 5 2 abnormal choroid pigmentation 0.272203573259024 0.505686397351443 0.745201628538193 0.625 5.2 5 2 non-pigmented tail tip 0.272203573259024 0.505686397351443 0.745201628538193 0.625 5.2 5 2 abnormal canal of Schlemm morphology 0.272203573259024 0.505686397351443 0.745201628538193 0.625 5.2 5 2 ectrodactyly 0.272203573259024 0.505686397351443 0.745201628538193 0.625 5.2 5 2 abnormal olfactory tract morphology 0.272203573259024 0.505686397351443 0.745201628538193 0.625 5.2 5 2 choroidal neovascularization 0.272203573259024 0.505686397351443 0.745201628538193 0.625 5.2 5 2 increased pulmonary ventilation 0.272203573259024 0.505686397351443 0.745201628538193 0.625 5.2 5 2 abnormal corneocyte envelope morphology 0.272203573259024 0.505686397351443 0.745201628538193 0.625 5.2 5 2 abnormal mitotic spindle assembly checkpoint 0.272203573259024 0.505686397351443 0.745201628538193 0.625 5.2 5 2 abnormal sphingomyelin level 0.272203573259024 0.505686397351443 0.745201628538193 0.625 5.2 5 2 skin fibrosis 0.272203573259024 0.505686397351443 0.745201628538193 0.625 5.2 5 2 abnormal circulating serum amyloid protein level 0.272203573259024 0.505686397351443 0.745201628538193 0.625 5.2 5 2 decreased quadriceps weight 0.272203573259024 0.505686397351443 0.745201628538193 0.625 5.2 5 2 myocardial trabeculae hypoplasia 0.272203573259024 0.505686397351443 0.745201628538193 0.625 5.2 5 2 abnormal bronchiole epithelium morphology 0.272203573259024 0.505686397351443 0.745201628538193 0.625 5.2 5 2 abnormal bronchus epithelium morphology 0.272203573259024 0.505686397351443 0.745201628538193 0.625 5.2 5 2 abnormal branching involved in ureteric bud morphogenesis 0.272203573259024 0.505686397351443 0.745201628538193 0.625 5.2 5 2 abnormal kidney mesenchyme morphology 0.272203573259024 0.505686397351443 0.745201628538193 0.625 5.2 5 2 increased circulating ferritin level 0.272203573259024 0.505686397351443 0.745201628538193 0.625 5.2 5 2 abnormal heart echocardiography feature 0.272203573259024 0.505686397351443 0.745201628538193 0.625 5.2 5 2 increased cardiac stroke volume 0.272203573259024 0.505686397351443 0.745201628538193 0.625 5.2 5 2 shortened PQ interval 0.272203573259024 0.505686397351443 0.745201628538193 0.625 5.2 5 2 decreased vascular endothelial cell proliferation 0.272203573259024 0.505686397351443 0.745201628538193 0.625 5.2 5 2 abnormal lipid homeostasis 9.25755930607026e-05 0.0011659837353848 0.742908700450383 0.623076923076923 5.2 5 2 abnormal male meiosis 0.00642940704070866 0.0395870049845614 0.742758344510199 0.622950819672131 5.2 5 2 abnormal blood homeostasis 0.000248351146241118 0.00264005759091787 0.742586885981919 0.62280701754386 5.2 5 2 abnormal pancreatic islet morphology 0.0108430740868743 0.0587628470394333 0.742389546921068 0.622641509433962 5.2 5 2 abnormal T cell activation 0.00305010133809288 0.0217708094074779 0.741173511627176 0.621621621621622 5.2 5 2 abnormal hair follicle development 0.0317746773369711 0.134535335958665 0.741173511627176 0.621621621621622 5.2 5 2 increased inflammatory response 0.000885020033674849 0.00786245476345067 0.740495091936899 0.621052631578947 5.2 5 2 decreased bone strength 0.0556981903370279 0.195552926553785 0.740062306962068 0.620689655172414 5.2 5 2 increased double-positive T cell number 0.0556981903370279 0.195552926553785 0.740062306962068 0.620689655172414 5.2 5 2 abnormal hematopoietic system physiology 0.100419183583421 0.28145658497325 0.738104470171163 0.619047619047619 5.2 5 2 decreased regulatory T cell number 0.042915495785221 0.161167394232067 0.736434550555391 0.617647058823529 5.2 5 2 increased susceptibility to weight gain 0.042915495785221 0.161167394232067 0.736434550555391 0.617647058823529 5.2 5 2 abnormal tibia morphology 0.0193468613916418 0.0918629541196593 0.735688416258982 0.617021276595745 5.2 5 2 increased respiratory quotient 0.0193468613916418 0.0918629541196593 0.735688416258982 0.617021276595745 5.2 5 2 abnormal eye physiology 0.00897305708111904 0.0514775725621223 0.73526560682435 0.616666666666667 5.2 5 2 decreased percent body fat/body weight 0.00423610147419799 0.0282646024198009 0.734993387051368 0.616438356164384 5.2 5 2 increased susceptibility to otitis media 0.0759851445694251 0.244365058151134 0.733736988099144 0.615384615384615 5.2 5 2 pulmonary edema 0.0759851445694251 0.244365058151134 0.733736988099144 0.615384615384615 5.2 5 2 absent common myeloid progenitor cells 0.190838425027456 0.432178719593789 0.733736988099144 0.615384615384615 5.2 5 2 absent trabeculae carneae 0.190838425027456 0.432178719593789 0.733736988099144 0.615384615384615 5.2 5 2 short hair 0.190838425027456 0.432178719593789 0.733736988099144 0.615384615384615 5.2 5 2 small trigeminal ganglion 0.190838425027456 0.432178719593789 0.733736988099144 0.615384615384615 5.2 5 2 pup cannibalization 0.190838425027456 0.432178719593789 0.733736988099144 0.615384615384615 5.2 5 2 abnormal digestion 0.190838425027456 0.432178719593789 0.733736988099144 0.615384615384615 5.2 5 2 increased circulating adrenocorticotropin level 0.190838425027456 0.432178719593789 0.733736988099144 0.615384615384615 5.2 5 2 abnormal pulmonary alveolus epithelial cell morphology 0.190838425027456 0.432178719593789 0.733736988099144 0.615384615384615 5.2 5 2 abnormal soleus morphology 0.190838425027456 0.432178719593789 0.733736988099144 0.615384615384615 5.2 5 2 anal atresia 0.190838425027456 0.432178719593789 0.733736988099144 0.615384615384615 5.2 5 2 abnormal telomere length 0.190838425027456 0.432178719593789 0.733736988099144 0.615384615384615 5.2 5 2 abnormal GABAergic neuron morphology 0.190838425027456 0.432178719593789 0.733736988099144 0.615384615384615 5.2 5 2 decreased alcohol consumption 0.190838425027456 0.432178719593789 0.733736988099144 0.615384615384615 5.2 5 2 abnormal vestibulocochlear ganglion morphology 0.190838425027456 0.432178719593789 0.733736988099144 0.615384615384615 5.2 5 2 vestibular hair cell degeneration 0.190838425027456 0.432178719593789 0.733736988099144 0.615384615384615 5.2 5 2 small pituitary gland 0.190838425027456 0.432178719593789 0.733736988099144 0.615384615384615 5.2 5 2 orthokeratosis 0.190838425027456 0.432178719593789 0.733736988099144 0.615384615384615 5.2 5 2 empty decidua capsularis 0.190838425027456 0.432178719593789 0.733736988099144 0.615384615384615 5.2 5 2 small lens 0.0332452179733743 0.140522480388732 0.733736988099144 0.615384615384615 5.2 5 2 decreased macrophage cell number 0.0258651573360842 0.115614696987438 0.731652508019317 0.613636363636364 5.2 5 2 abnormal limb morphology 0.00442952466758657 0.0290724079435926 0.731291198138813 0.613333333333333 5.2 5 2 abnormal cranial ganglia morphology 0.0580671590082104 0.203296351911222 0.730778371211647 0.612903225806452 5.2 5 2 abnormal capillary morphology 0.0580671590082104 0.203296351911222 0.730778371211647 0.612903225806452 5.2 5 2 improved glucose tolerance 7.65206849131029e-06 0.000140996447200995 0.729993432037414 0.612244897959184 5.2 5 2 abnormal respiratory system physiology 0.0201944679502557 0.0937196623624273 0.729993432037414 0.612244897959184 5.2 5 2 abnormal eye electrophysiology 0.000413174583782163 0.00403839598097497 0.729189031561339 0.611570247933884 5.2 5 2 abnormal retinal blood vessel morphology 0.0446979482622388 0.166242782377508 0.728641592348455 0.611111111111111 5.2 5 2 abnormal retinal rod cell morphology 0.139357270305343 0.353545344094382 0.728641592348455 0.611111111111111 5.2 5 2 abnormal thyroid cartilage morphology 0.139357270305343 0.353545344094382 0.728641592348455 0.611111111111111 5.2 5 2 abnormal Peyer's patch follicle morphology 0.139357270305343 0.353545344094382 0.728641592348455 0.611111111111111 5.2 5 2 abnormal white adipose tissue morphology 0.139357270305343 0.353545344094382 0.728641592348455 0.611111111111111 5.2 5 2 abnormal neutrophil morphology 0.139357270305343 0.353545344094382 0.728641592348455 0.611111111111111 5.2 5 2 abnormal glycogen homeostasis 0.139357270305343 0.353545344094382 0.728641592348455 0.611111111111111 5.2 5 2 abnormal sperm axoneme morphology 0.139357270305343 0.353545344094382 0.728641592348455 0.611111111111111 5.2 5 2 decreased tumor latency 0.139357270305343 0.353545344094382 0.728641592348455 0.611111111111111 5.2 5 2 abnormal macrophage chemotaxis 0.139357270305343 0.353545344094382 0.728641592348455 0.611111111111111 5.2 5 2 abnormal aerobic respiration 0.139357270305343 0.353545344094382 0.728641592348455 0.611111111111111 5.2 5 2 decreased fluid intake 0.139357270305343 0.353545344094382 0.728641592348455 0.611111111111111 5.2 5 2 increased adipocyte glucose uptake 0.139357270305343 0.353545344094382 0.728641592348455 0.611111111111111 5.2 5 2 obese 0.00461887108899601 0.0299594311183249 0.727781330728209 0.61038961038961 5.2 5 2 increased circulating glucose level 0.000168346905585553 0.00192978307670075 0.72723222756635 0.609929078014184 5.2 5 2 abnormal innervation pattern to muscle 0.104016738480116 0.289906596044021 0.725761586054588 0.608695652173913 5.2 5 2 abnormal circulating insulin level 0.104016738480116 0.289906596044021 0.725761586054588 0.608695652173913 5.2 5 2 failure of embryo implantation 0.104016738480116 0.289906596044021 0.725761586054588 0.608695652173913 5.2 5 2 abnormal postnatal growth 0.104016738480116 0.289906596044021 0.725761586054588 0.608695652173913 5.2 5 2 abnormal cochlear ganglion morphology 0.104016738480116 0.289906596044021 0.725761586054588 0.608695652173913 5.2 5 2 abnormal cardiovascular development 0.104016738480116 0.289906596044021 0.725761586054588 0.608695652173913 5.2 5 2 decreased epididymis weight 0.104016738480116 0.289906596044021 0.725761586054588 0.608695652173913 5.2 5 2 abnormal B cell morphology 0.104016738480116 0.289906596044021 0.725761586054588 0.608695652173913 5.2 5 2 abnormal ulna morphology 0.104016738480116 0.289906596044021 0.725761586054588 0.608695652173913 5.2 5 2 abnormal palatal shelf fusion at midline 0.104016738480116 0.289906596044021 0.725761586054588 0.608695652173913 5.2 5 2 abnormal thrombosis 0.020993469108326 0.0960832647782172 0.724745113244988 0.607843137254902 5.2 5 2 abnormal dendritic cell physiology 0.00115562917611431 0.010019960388575 0.724308124934319 0.607476635514019 5.2 5 2 increased circulating luteinizing hormone level 0.0787252956467285 0.25219468502413 0.723910153437102 0.607142857142857 5.2 5 2 failure of blastocyst to hatch from the zona pellucida 0.0787252956467285 0.25219468502413 0.723910153437102 0.607142857142857 5.2 5 2 abnormal retinal inner nuclear layer morphology 0.0787252956467285 0.25219468502413 0.723910153437102 0.607142857142857 5.2 5 2 increased triglyceride level 0.0787252956467285 0.25219468502413 0.723910153437102 0.607142857142857 5.2 5 2 abnormal T cell subpopulation ratio 0.0601638970591433 0.208727606603374 0.722619761006733 0.606060606060606 5.2 5 2 head tossing 0.0601638970591433 0.208727606603374 0.722619761006733 0.606060606060606 5.2 5 2 decreased sensitivity to xenobiotic induced morbidity/mortality 0.0601638970591433 0.208727606603374 0.722619761006733 0.606060606060606 5.2 5 2 abnormal coat/ hair morphology 0.0217453317777508 0.0993416212987237 0.719892893984066 0.60377358490566 5.2 5 2 abnormal placenta development 0.0217453317777508 0.0993416212987237 0.719892893984066 0.60377358490566 5.2 5 2 dermatitis 0.017018905324112 0.0849238254638487 0.719505020657566 0.603448275862069 5.2 5 2 abnormal lipid level 0.00516039475167557 0.0324563386720429 0.718266629916331 0.602409638554217 5.2 5 2 weight loss 8.87016074310315e-05 0.00113398156569034 0.715393563396665 0.6 5.2 5 2 increased body length 0.0287666908900184 0.125759479066644 0.715393563396665 0.6 5.2 5 2 abnormal digestive system physiology 0.0287666908900184 0.125759479066644 0.715393563396665 0.6 5.2 5 2 impaired ovarian folliculogenesis 0.0477665619785654 0.174477713541383 0.715393563396665 0.6 5.2 5 2 decreased triglyceride level 0.0620170659318399 0.214857174798679 0.715393563396665 0.6 5.2 5 2 decreased bone volume 0.0620170659318399 0.214857174798679 0.715393563396665 0.6 5.2 5 2 gastrointestinal hemorrhage 0.0810755051730146 0.259389477965111 0.715393563396665 0.6 5.2 5 2 arrested T cell differentiation 0.0810755051730146 0.259389477965111 0.715393563396665 0.6 5.2 5 2 decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 0.106967720170191 0.297964394091098 0.715393563396665 0.6 5.2 5 2 abnormal vascular regression 0.142960020808975 0.361579107028292 0.715393563396665 0.6 5.2 5 2 abnormal trachea morphology 0.142960020808975 0.361579107028292 0.715393563396665 0.6 5.2 5 2 abnormal hyoid bone morphology 0.142960020808975 0.361579107028292 0.715393563396665 0.6 5.2 5 2 abnormal physiological neovascularization 0.142960020808975 0.361579107028292 0.715393563396665 0.6 5.2 5 2 kidney atrophy 0.142960020808975 0.361579107028292 0.715393563396665 0.6 5.2 5 2 abnormal heart electrocardiography waveform feature 0.142960020808975 0.361579107028292 0.715393563396665 0.6 5.2 5 2 macrocytosis 0.194846186960963 0.432178719593789 0.715393563396665 0.6 5.2 5 2 decreased salivation 0.194846186960963 0.432178719593789 0.715393563396665 0.6 5.2 5 2 abnormal enteric neuron morphology 0.194846186960963 0.432178719593789 0.715393563396665 0.6 5.2 5 2 abnormal epidermis stratum spinosum morphology 0.194846186960963 0.432178719593789 0.715393563396665 0.6 5.2 5 2 increased airway responsiveness 0.194846186960963 0.432178719593789 0.715393563396665 0.6 5.2 5 2 abnormal bronchus morphology 0.194846186960963 0.432178719593789 0.715393563396665 0.6 5.2 5 2 abnormal lymph node B cell domain morphology 0.194846186960963 0.432178719593789 0.715393563396665 0.6 5.2 5 2 altered righting response 0.194846186960963 0.432178719593789 0.715393563396665 0.6 5.2 5 2 abnormal pericyte morphology 0.194846186960963 0.432178719593789 0.715393563396665 0.6 5.2 5 2 absent chorion 0.194846186960963 0.432178719593789 0.715393563396665 0.6 5.2 5 2 ostium primum atrial septal defect 0.194846186960963 0.432178719593789 0.715393563396665 0.6 5.2 5 2 bicuspid aortic valve 0.194846186960963 0.432178719593789 0.715393563396665 0.6 5.2 5 2 abnormal microglial cell activation 0.194846186960963 0.432178719593789 0.715393563396665 0.6 5.2 5 2 decreased trabecular bone mass 0.194846186960963 0.432178719593789 0.715393563396665 0.6 5.2 5 2 abnormal auchene hair morphology 0.274743271514842 0.505686397351443 0.715393563396665 0.6 5.2 5 2 rhinitis 0.274743271514842 0.505686397351443 0.715393563396665 0.6 5.2 5 2 abnormal mammary gland physiology 0.274743271514842 0.505686397351443 0.715393563396665 0.6 5.2 5 2 abnormal gland morphology 0.274743271514842 0.505686397351443 0.715393563396665 0.6 5.2 5 2 ketoaciduria 0.274743271514842 0.505686397351443 0.715393563396665 0.6 5.2 5 2 abnormal primordial germ cell migration 0.274743271514842 0.505686397351443 0.715393563396665 0.6 5.2 5 2 intestinal hypoperistalsis 0.274743271514842 0.505686397351443 0.715393563396665 0.6 5.2 5 2 abnormal hypaxial muscle morphology 0.274743271514842 0.505686397351443 0.715393563396665 0.6 5.2 5 2 abnormal glial cell physiology 0.274743271514842 0.505686397351443 0.715393563396665 0.6 5.2 5 2 abnormal submandibular gland morphology 0.274743271514842 0.505686397351443 0.715393563396665 0.6 5.2 5 2 abnormal hindlimb zeugopod morphology 0.274743271514842 0.505686397351443 0.715393563396665 0.6 5.2 5 2 increased defecation amount 0.274743271514842 0.505686397351443 0.715393563396665 0.6 5.2 5 2 abnormal utricular macula morphology 0.274743271514842 0.505686397351443 0.715393563396665 0.6 5.2 5 2 decreased prolactin level 0.274743271514842 0.505686397351443 0.715393563396665 0.6 5.2 5 2 abnormal gonadal fat pad morphology 0.274743271514842 0.505686397351443 0.715393563396665 0.6 5.2 5 2 tachypnea 0.274743271514842 0.505686397351443 0.715393563396665 0.6 5.2 5 2 decreased thyroxine level 0.274743271514842 0.505686397351443 0.715393563396665 0.6 5.2 5 2 absent inguinal lymph nodes 0.274743271514842 0.505686397351443 0.715393563396665 0.6 5.2 5 2 increased compact bone area 0.274743271514842 0.505686397351443 0.715393563396665 0.6 5.2 5 2 decreased macrophage cytokine production 0.274743271514842 0.505686397351443 0.715393563396665 0.6 5.2 5 2 sparse hair 0.00695471942569411 0.0426105038704781 0.712485459480419 0.597560975609756 5.2 5 2 maternal effect 0.0142097676021329 0.0733336035483518 0.711834391439468 0.597014925373134 5.2 5 2 abnormal renal glomerulus morphology 0.00223747755630842 0.016942847553477 0.711018067596074 0.596330275229358 5.2 5 2 abnormal skin condition 0.0296005933342784 0.127955782093655 0.710807707221046 0.596153846153846 5.2 5 2 increased percent body fat/body weight 0.0296005933342784 0.127955782093655 0.710807707221046 0.596153846153846 5.2 5 2 decreased food intake 0.00906351123013893 0.0517691944545823 0.709356486912305 0.594936708860759 5.2 5 2 decreased T cell proliferation 0.000481502116448401 0.00460186047103189 0.708948576339038 0.594594594594595 5.2 5 2 increased granulocyte number 0.0114959187553633 0.0618963158094507 0.708948576339038 0.594594594594595 5.2 5 2 increased insulin secretion 0.0636520789526315 0.220368192616104 0.708948576339038 0.594594594594595 5.2 5 2 abnormal urine homeostasis 0.00460590270938492 0.0299143158997258 0.707941547111283 0.59375 5.2 5 2 syndactyly 0.0237346512484018 0.106763010814466 0.707310020307438 0.593220338983051 5.2 5 2 increased spleen weight 0.00236489802953431 0.0178533652457256 0.706952341409684 0.592920353982301 5.2 5 2 decreased B cell number 5.74068919978984e-05 0.000797763373434481 0.706132805294443 0.592233009708738 5.2 5 2 increased liver weight 0.00754044668591304 0.0454161286469944 0.704554266981564 0.590909090909091 5.2 5 2 hypertension 0.0502611073938132 0.182650846810972 0.704554266981564 0.590909090909091 5.2 5 2 abnormal basisphenoid bone morphology 0.145689169290395 0.366803450009977 0.704554266981564 0.590909090909091 5.2 5 2 abnormal vascular branching morphogenesis 0.145689169290395 0.366803450009977 0.704554266981564 0.590909090909091 5.2 5 2 parakeratosis 0.145689169290395 0.366803450009977 0.704554266981564 0.590909090909091 5.2 5 2 abnormal retinal layer morphology 0.145689169290395 0.366803450009977 0.704554266981564 0.590909090909091 5.2 5 2 abnormal retinal outer plexiform layer morphology 0.145689169290395 0.366803450009977 0.704554266981564 0.590909090909091 5.2 5 2 abnormal temporal bone morphology 0.145689169290395 0.366803450009977 0.704554266981564 0.590909090909091 5.2 5 2 abnormal sperm midpiece morphology 0.145689169290395 0.366803450009977 0.704554266981564 0.590909090909091 5.2 5 2 failure of palatal shelf elevation 0.145689169290395 0.366803450009977 0.704554266981564 0.590909090909091 5.2 5 2 spleen hypoplasia 0.00384479854488658 0.0265296432188776 0.704038110009417 0.59047619047619 5.2 5 2 decreased neutrophil cell number 0.00248710397043142 0.018396412484557 0.703164613595013 0.58974358974359 5.2 5 2 decreased B-1 B cell number 0.0650914247959683 0.223639391132557 0.703164613595013 0.58974358974359 5.2 5 2 abnormal response to injury 0.0650914247959683 0.223639391132557 0.703164613595013 0.58974358974359 5.2 5 2 distended abdomen 0.039871293435293 0.157178831093964 0.701366238624182 0.588235294117647 5.2 5 2 thin skin 0.0848044703076043 0.267024827071749 0.701366238624182 0.588235294117647 5.2 5 2 abnormal spleen red pulp morphology 0.0848044703076043 0.267024827071749 0.701366238624182 0.588235294117647 5.2 5 2 decreased cytotoxic T cell cytolysis 0.0848044703076043 0.267024827071749 0.701366238624182 0.588235294117647 5.2 5 2 abnormal skin physiology 0.0848044703076043 0.267024827071749 0.701366238624182 0.588235294117647 5.2 5 2 hydroureter 0.197404497671765 0.432178719593789 0.701366238624182 0.588235294117647 5.2 5 2 abnormal urinary bladder morphology 0.197404497671765 0.432178719593789 0.701366238624182 0.588235294117647 5.2 5 2 abnormal middle ear morphology 0.111347028168804 0.30303690653162 0.698947734353064 0.586206896551724 5.2 5 2 decreased granulocyte number 0.111347028168804 0.30303690653162 0.698947734353064 0.586206896551724 5.2 5 2 decreased retinal photoreceptor cell number 0.111347028168804 0.30303690653162 0.698947734353064 0.586206896551724 5.2 5 2 abnormal outer ear morphology 0.111347028168804 0.30303690653162 0.698947734353064 0.586206896551724 5.2 5 2 abnormal embryonic erythropoiesis 0.111347028168804 0.30303690653162 0.698947734353064 0.586206896551724 5.2 5 2 increased retinal apoptosis 0.111347028168804 0.30303690653162 0.698947734353064 0.586206896551724 5.2 5 2 short ulna 0.0663549955541342 0.224874729483527 0.697944939899186 0.585365853658537 5.2 5 2 epidermal hyperplasia 0.0323582044504177 0.136889512874854 0.69552151996898 0.583333333333333 5.2 5 2 abnormal phalanx morphology 0.0522725180059524 0.189440864271498 0.69552151996898 0.583333333333333 5.2 5 2 impaired wound healing 0.0862638306692813 0.267024827071749 0.69552151996898 0.583333333333333 5.2 5 2 curly vibrissae 0.147728845537217 0.371000003305227 0.69552151996898 0.583333333333333 5.2 5 2 abnormal osteoblast morphology 0.147728845537217 0.371000003305227 0.69552151996898 0.583333333333333 5.2 5 2 hypopigmentation 0.147728845537217 0.371000003305227 0.69552151996898 0.583333333333333 5.2 5 2 abnormal inner cell mass apoptosis 0.147728845537217 0.371000003305227 0.69552151996898 0.583333333333333 5.2 5 2 abnormal superior cervical ganglion morphology 0.275052741956383 0.505686397351443 0.69552151996898 0.583333333333333 5.2 5 2 abnormal enteric nervous system morphology 0.275052741956383 0.505686397351443 0.69552151996898 0.583333333333333 5.2 5 2 absent optic nerve 0.275052741956383 0.505686397351443 0.69552151996898 0.583333333333333 5.2 5 2 interstitial pneumonia 0.275052741956383 0.505686397351443 0.69552151996898 0.583333333333333 5.2 5 2 small thyroid gland 0.275052741956383 0.505686397351443 0.69552151996898 0.583333333333333 5.2 5 2 impaired sperm capacitation 0.275052741956383 0.505686397351443 0.69552151996898 0.583333333333333 5.2 5 2 vestibular saccular macula degeneration 0.275052741956383 0.505686397351443 0.69552151996898 0.583333333333333 5.2 5 2 small parietal bone 0.275052741956383 0.505686397351443 0.69552151996898 0.583333333333333 5.2 5 2 abnormal anogenital distance 0.275052741956383 0.505686397351443 0.69552151996898 0.583333333333333 5.2 5 2 impaired behavioral response to cocaine 0.275052741956383 0.505686397351443 0.69552151996898 0.583333333333333 5.2 5 2 decreased prostaglandin level 0.275052741956383 0.505686397351443 0.69552151996898 0.583333333333333 5.2 5 2 abnormal respiratory motile cilium morphology 0.275052741956383 0.505686397351443 0.69552151996898 0.583333333333333 5.2 5 2 increased food intake 0.0128778435084194 0.0670334071920718 0.69552151996898 0.583333333333333 5.2 5 2 abnormal femur morphology 0.0258311347636778 0.115566452742174 0.694038531653481 0.582089552238806 5.2 5 2 increased B cell number 0.00436181338828123 0.0288948356946726 0.692973822093636 0.581196581196581 5.2 5 2 kidney inflammation 0.0531213238857214 0.189440864271498 0.691547111283443 0.58 5.2 5 2 decreased susceptibility to induced arthritis 0.0420534554877771 0.161167394232067 0.690292034856432 0.578947368421053 5.2 5 2 increased bone marrow cell number 0.0874969858735439 0.267024827071749 0.690292034856432 0.578947368421053 5.2 5 2 abnormal nail morphology 0.19892475774082 0.432178719593789 0.690292034856432 0.578947368421053 5.2 5 2 stereotypic behavior 0.19892475774082 0.432178719593789 0.690292034856432 0.578947368421053 5.2 5 2 decreased tumor incidence 0.19892475774082 0.432178719593789 0.690292034856432 0.578947368421053 5.2 5 2 abnormal nasal septum morphology 0.19892475774082 0.432178719593789 0.690292034856432 0.578947368421053 5.2 5 2 increased left ventricle weight 0.19892475774082 0.432178719593789 0.690292034856432 0.578947368421053 5.2 5 2 decreased liver regeneration 0.19892475774082 0.432178719593789 0.690292034856432 0.578947368421053 5.2 5 2 decreased liver glycogen level 0.19892475774082 0.432178719593789 0.690292034856432 0.578947368421053 5.2 5 2 thin interventricular septum 0.19892475774082 0.432178719593789 0.690292034856432 0.578947368421053 5.2 5 2 alopecia 0.0107451558920722 0.0584468780568535 0.690292034856431 0.578947368421053 5.2 5 2 abnormal autopod morphology 0.0684232274740743 0.231410983469422 0.688897505493085 0.577777777777778 5.2 5 2 albuminuria 0.0684232274740743 0.231410983469422 0.688897505493085 0.577777777777778 5.2 5 2 heart inflammation 0.149216686898508 0.374169867600845 0.687878426342947 0.576923076923077 5.2 5 2 abnormal colon morphology 0.042648940703471 0.161167394232067 0.687101162584368 0.576271186440678 5.2 5 2 abnormal skeleton physiology 0.114197780460217 0.310286159360775 0.686488772956396 0.575757575757576 5.2 5 2 decreased systemic arterial blood pressure 0.114197780460217 0.310286159360775 0.686488772956396 0.575757575757576 5.2 5 2 abnormal cochlea morphology 0.0545464442616748 0.191779901202708 0.684481495842489 0.574074074074074 5.2 5 2 abnormal NK cell physiology 0.043185834046663 0.161167394232067 0.684119527838341 0.573770491803279 5.2 5 2 abnormal epidermis stratum corneum morphology 0.0699750263496039 0.235697871421313 0.681327203234919 0.571428571428571 5.2 5 2 impaired fertilization 0.0347270281468871 0.145304428116706 0.681327203234919 0.571428571428571 5.2 5 2 disheveled coat 0.0893889398789462 0.267024827071749 0.681327203234919 0.571428571428571 5.2 5 2 abnormal intestinal goblet cell morphology 0.115187676141957 0.312671890109028 0.681327203234919 0.571428571428571 5.2 5 2 abnormal circulating cholesterol level 0.150257592552427 0.376021892831148 0.681327203234919 0.571428571428571 5.2 5 2 reddish skin 0.150257592552427 0.376021892831148 0.681327203234919 0.571428571428571 5.2 5 2 corneal vascularization 0.150257592552427 0.376021892831148 0.681327203234919 0.571428571428571 5.2 5 2 dry skin 0.199681137109714 0.432178719593789 0.681327203234919 0.571428571428571 5.2 5 2 increased bone ossification 0.199681137109714 0.432178719593789 0.681327203234919 0.571428571428571 5.2 5 2 abnormal vasoconstriction 0.27406145452239 0.505686397351443 0.681327203234919 0.571428571428571 5.2 5 2 absent atrioventricular cushions 0.27406145452239 0.505686397351443 0.681327203234919 0.571428571428571 5.2 5 2 abnormal olfactory system physiology 0.27406145452239 0.505686397351443 0.681327203234919 0.571428571428571 5.2 5 2 abnormal spleen periarteriolar lymphoid sheath morphology 0.27406145452239 0.505686397351443 0.681327203234919 0.571428571428571 5.2 5 2 vascular smooth muscle hypoplasia 0.27406145452239 0.505686397351443 0.681327203234919 0.571428571428571 5.2 5 2 abnormal decidualization 0.27406145452239 0.505686397351443 0.681327203234919 0.571428571428571 5.2 5 2 abnormal squamosal bone morphology 0.27406145452239 0.505686397351443 0.681327203234919 0.571428571428571 5.2 5 2 increased pulmonary respiratory rate 0.27406145452239 0.505686397351443 0.681327203234919 0.571428571428571 5.2 5 2 increased lung compliance 0.27406145452239 0.505686397351443 0.681327203234919 0.571428571428571 5.2 5 2 abnormal heart left ventricle morphology 0.0350829469572232 0.146670303455618 0.678961483779243 0.569444444444444 5.2 5 2 renal interstitial fibrosis 0.0900910399667466 0.267024827071749 0.677456025943812 0.568181818181818 5.2 5 2 abnormal photoreceptor outer segment morphology 0.0900910399667466 0.267024827071749 0.677456025943812 0.568181818181818 5.2 5 2 increased white adipose tissue amount 0.115941754797384 0.314338000063753 0.6767236410509 0.567567567567568 5.2 5 2 decreased circulating chloride level 0.115941754797384 0.314338000063753 0.6767236410509 0.567567567567568 5.2 5 2 liver inflammation 0.00967386723224297 0.0546010627686456 0.675649476541295 0.566666666666667 5.2 5 2 abnormal fat pad morphology 0.15093286593253 0.377332164831324 0.675649476541295 0.566666666666667 5.2 5 2 abnormal epidermal layer morphology 0.0448225469472128 0.166242782377508 0.673921472764975 0.565217391304348 5.2 5 2 hyperkeratosis 0.0448225469472128 0.166242782377508 0.673921472764975 0.565217391304348 5.2 5 2 abnormal coat appearance 0.0448225469472128 0.166242782377508 0.673921472764975 0.565217391304348 5.2 5 2 increased lymphocyte cell number 0.0448225469472128 0.166242782377508 0.673921472764975 0.565217391304348 5.2 5 2 abnormal pulmonary artery morphology 0.199863329343757 0.432178719593789 0.673921472764975 0.565217391304348 5.2 5 2 abnormal carpal bone morphology 0.199863329343757 0.432178719593789 0.673921472764975 0.565217391304348 5.2 5 2 hypotension 0.199863329343757 0.432178719593789 0.673921472764975 0.565217391304348 5.2 5 2 conjunctivitis 0.199863329343757 0.432178719593789 0.673921472764975 0.565217391304348 5.2 5 2 abnormal sacral vertebrae morphology 0.199863329343757 0.432178719593789 0.673921472764975 0.565217391304348 5.2 5 2 increased susceptibility to age related obesity 0.199863329343757 0.432178719593789 0.673921472764975 0.565217391304348 5.2 5 2 increased circulating calcium level 0.0715335675559062 0.238278895680537 0.672036377736261 0.563636363636364 5.2 5 2 abnormal T-helper 2 physiology 0.0715335675559062 0.238278895680537 0.672036377736261 0.563636363636364 5.2 5 2 decreased eosinophil cell number 0.0568273459422783 0.199376619226259 0.670681465684374 0.5625 5.2 5 2 increased dopamine level 0.151306454179674 0.377786679799015 0.670681465684374 0.5625 5.2 5 2 abnormal bone marrow cell number 0.272268320661563 0.505686397351443 0.670681465684374 0.5625 5.2 5 2 vasculature congestion 0.272268320661563 0.505686397351443 0.670681465684374 0.5625 5.2 5 2 decreased mast cell number 0.272268320661563 0.505686397351443 0.670681465684374 0.5625 5.2 5 2 abnormal mouth morphology 0.272268320661563 0.505686397351443 0.670681465684374 0.5625 5.2 5 2 increased pancreatic beta cell number 0.272268320661563 0.505686397351443 0.670681465684374 0.5625 5.2 5 2 bowed radius 0.272268320661563 0.505686397351443 0.670681465684374 0.5625 5.2 5 2 decreased circulating triiodothyronine level 0.272268320661563 0.505686397351443 0.670681465684374 0.5625 5.2 5 2 abnormal urinary bladder physiology 0.272268320661563 0.505686397351443 0.670681465684374 0.5625 5.2 5 2 abnormal keratinocyte physiology 0.199606641458885 0.432178719593789 0.667700659170221 0.56 5.2 5 2 abnormal oocyte morphology 0.151429306653526 0.377813841826124 0.666297926692973 0.558823529411765 5.2 5 2 increased susceptibility to injury 0.0916570081915246 0.267024827071749 0.664949145464849 0.557692307692308 5.2 5 2 decreased body temperature 0.0916570081915246 0.267024827071749 0.664949145464849 0.557692307692308 5.2 5 2 abnormal small intestine morphology 0.0918006443377964 0.267024827071749 0.662401447589505 0.555555555555556 5.2 5 2 abnormal epidermis stratum granulosum morphology 0.151342482982802 0.377786679799015 0.662401447589505 0.555555555555556 5.2 5 2 wrinkled skin 0.199010052620894 0.432178719593789 0.662401447589505 0.555555555555556 5.2 5 2 abnormal stomach glandular epithelium morphology 0.269963531879792 0.505686397351443 0.662401447589505 0.555555555555556 5.2 5 2 eye inflammation 0.269963531879792 0.505686397351443 0.662401447589505 0.555555555555556 5.2 5 2 increased circulating renin level 0.269963531879792 0.505686397351443 0.662401447589505 0.555555555555556 5.2 5 2 decreased activity of thyroid 0.269963531879792 0.505686397351443 0.662401447589505 0.555555555555556 5.2 5 2 decreased heart rate variability 0.269963531879792 0.505686397351443 0.662401447589505 0.555555555555556 5.2 5 2 increased susceptibility to autoimmune disorder 0.269963531879792 0.505686397351443 0.662401447589505 0.555555555555556 5.2 5 2 synostosis 0.393144132576757 0.612988332963549 0.662401447589505 0.555555555555556 5.2 5 2 absent parathyroid glands 0.393144132576757 0.612988332963549 0.662401447589505 0.555555555555556 5.2 5 2 abnormal sympathetic neuron morphology 0.393144132576757 0.612988332963549 0.662401447589505 0.555555555555556 5.2 5 2 abnormal geniculate ganglion morphology 0.393144132576757 0.612988332963549 0.662401447589505 0.555555555555556 5.2 5 2 small geniculate ganglion 0.393144132576757 0.612988332963549 0.662401447589505 0.555555555555556 5.2 5 2 wavy vibrissae 0.393144132576757 0.612988332963549 0.662401447589505 0.555555555555556 5.2 5 2 multifocal hepatic necrosis 0.393144132576757 0.612988332963549 0.662401447589505 0.555555555555556 5.2 5 2 abnormal lung volume 0.393144132576757 0.612988332963549 0.662401447589505 0.555555555555556 5.2 5 2 increased pheochromocytoma incidence 0.393144132576757 0.612988332963549 0.662401447589505 0.555555555555556 5.2 5 2 abnormal posterior semicircular canal morphology 0.393144132576757 0.612988332963549 0.662401447589505 0.555555555555556 5.2 5 2 abnormal postural reflex 0.393144132576757 0.612988332963549 0.662401447589505 0.555555555555556 5.2 5 2 decreased circulating bicarbonate level 0.393144132576757 0.612988332963549 0.662401447589505 0.555555555555556 5.2 5 2 decreased muscle weight 0.393144132576757 0.612988332963549 0.662401447589505 0.555555555555556 5.2 5 2 decreased thyroid-stimulating hormone level 0.393144132576757 0.612988332963549 0.662401447589505 0.555555555555556 5.2 5 2 abnormal posterior eye segment morphology 0.393144132576757 0.612988332963549 0.662401447589505 0.555555555555556 5.2 5 2 absent adrenal gland 0.393144132576757 0.612988332963549 0.662401447589505 0.555555555555556 5.2 5 2 decreased pulmonary ventilation 0.393144132576757 0.612988332963549 0.662401447589505 0.555555555555556 5.2 5 2 increased tidal volume 0.393144132576757 0.612988332963549 0.662401447589505 0.555555555555556 5.2 5 2 abnormal liver vasculature morphology 0.393144132576757 0.612988332963549 0.662401447589505 0.555555555555556 5.2 5 2 abnormal hyoid bone lesser horn morphology 0.393144132576757 0.612988332963549 0.662401447589505 0.555555555555556 5.2 5 2 prolonged RR interval 0.393144132576757 0.612988332963549 0.662401447589505 0.555555555555556 5.2 5 2 iris coloboma 0.393144132576757 0.612988332963549 0.662401447589505 0.555555555555556 5.2 5 2 decreased susceptibility to parasitic infection induced morbidity/mortality 0.393144132576757 0.612988332963549 0.662401447589505 0.555555555555556 5.2 5 2 decreased airway resistance 0.393144132576757 0.612988332963549 0.662401447589505 0.555555555555556 5.2 5 2 abnormal lung lobe morphology 0.393144132576757 0.612988332963549 0.662401447589505 0.555555555555556 5.2 5 2 increased core body temperature 0.393144132576757 0.612988332963549 0.662401447589505 0.555555555555556 5.2 5 2 decreased fatty acid oxidation 0.393144132576757 0.612988332963549 0.662401447589505 0.555555555555556 5.2 5 2 decreased bone mineral density of femur 0.393144132576757 0.612988332963549 0.662401447589505 0.555555555555556 5.2 5 2 altered response to myocardial infarction 0.117175805582586 0.316820452594221 0.662401447589505 0.555555555555556 5.2 5 2 decreased osteoclast cell number 0.117175805582586 0.316820452594221 0.662401447589505 0.555555555555556 5.2 5 2 increased systemic arterial blood pressure 0.117146579450455 0.316820452594221 0.659582718025294 0.553191489361702 5.2 5 2 abnormal retinal outer nuclear layer morphology 0.151079410526834 0.377508823390757 0.658915124181139 0.552631578947368 5.2 5 2 enlarged epididymis 0.198147517947654 0.432178719593789 0.65783316174406 0.551724137931034 5.2 5 2 increased urine protein level 0.0578797832255585 0.202925948940912 0.657306051838816 0.551282051282051 5.2 5 2 decreased urine osmolality 0.117014865762354 0.316820452594221 0.656994088833672 0.551020408163265 5.2 5 2 increased susceptibility to weight loss 0.150667551251562 0.376858254136009 0.65577743311361 0.55 5.2 5 2 abnormal thymocyte activation 0.267326102879742 0.505686397351443 0.65577743311361 0.55 5.2 5 2 abnormal incus morphology 0.267326102879742 0.505686397351443 0.65577743311361 0.55 5.2 5 2 absent mature ovarian follicles 0.19707529890738 0.432178719593789 0.653854332136737 0.548387096774194 5.2 5 2 abnormal CD8-positive, alpha beta T cell morphology 0.19707529890738 0.432178719593789 0.653854332136737 0.548387096774194 5.2 5 2 decreased IgM level 0.0462483710968569 0.171322149074358 0.65147523814473 0.54639175257732 5.2 5 2 abnormal joint morphology 0.116121136476064 0.314652861638573 0.650357784906059 0.545454545454545 5.2 5 2 abnormal middle ear ossicle morphology 0.195836862643022 0.432178719593789 0.650357784906059 0.545454545454545 5.2 5 2 abnormal circadian rhythm 0.149484687802647 0.374653058850462 0.650357784906059 0.545454545454545 5.2 5 2 abnormal enterocyte morphology 0.264471498492898 0.505686397351443 0.650357784906059 0.545454545454545 5.2 5 2 abnormal facial nerve morphology 0.264471498492898 0.505686397351443 0.650357784906059 0.545454545454545 5.2 5 2 increased activated T cell number 0.264471498492898 0.505686397351443 0.650357784906059 0.545454545454545 5.2 5 2 abnormal female reproductive system physiology 0.264471498492898 0.505686397351443 0.650357784906059 0.545454545454545 5.2 5 2 decreased susceptibility to viral infection induced morbidity/mortality 0.264471498492898 0.505686397351443 0.650357784906059 0.545454545454545 5.2 5 2 decreased atrioventricular cushion size 0.382754294677357 0.612988332963549 0.650357784906059 0.545454545454545 5.2 5 2 abnormal awl hair morphology 0.382754294677357 0.612988332963549 0.650357784906059 0.545454545454545 5.2 5 2 abnormal stomach epithelium morphology 0.382754294677357 0.612988332963549 0.650357784906059 0.545454545454545 5.2 5 2 abnormal large intestine morphology 0.382754294677357 0.612988332963549 0.650357784906059 0.545454545454545 5.2 5 2 abnormal food preference 0.382754294677357 0.612988332963549 0.650357784906059 0.545454545454545 5.2 5 2 abnormal larynx morphology 0.382754294677357 0.612988332963549 0.650357784906059 0.545454545454545 5.2 5 2 abnormal bronchiole morphology 0.382754294677357 0.612988332963549 0.650357784906059 0.545454545454545 5.2 5 2 rectal hemorrhage 0.382754294677357 0.612988332963549 0.650357784906059 0.545454545454545 5.2 5 2 impaired luteinization 0.382754294677357 0.612988332963549 0.650357784906059 0.545454545454545 5.2 5 2 abnormal lymph circulation 0.382754294677357 0.612988332963549 0.650357784906059 0.545454545454545 5.2 5 2 cyclopia 0.382754294677357 0.612988332963549 0.650357784906059 0.545454545454545 5.2 5 2 abnormal Bruch membrane morphology 0.382754294677357 0.612988332963549 0.650357784906059 0.545454545454545 5.2 5 2 increased glycogen level 0.382754294677357 0.612988332963549 0.650357784906059 0.545454545454545 5.2 5 2 abnormal superovulation 0.382754294677357 0.612988332963549 0.650357784906059 0.545454545454545 5.2 5 2 abnormal palate development 0.382754294677357 0.612988332963549 0.650357784906059 0.545454545454545 5.2 5 2 increased number of Howell-Jolly bodies 0.382754294677357 0.612988332963549 0.650357784906059 0.545454545454545 5.2 5 2 aberrant origin of the right subclavian artery 0.382754294677357 0.612988332963549 0.650357784906059 0.545454545454545 5.2 5 2 increased pancreatic beta cell proliferation 0.382754294677357 0.612988332963549 0.650357784906059 0.545454545454545 5.2 5 2 hypolactation 0.382754294677357 0.612988332963549 0.650357784906059 0.545454545454545 5.2 5 2 decreased colon length 0.382754294677357 0.612988332963549 0.650357784906059 0.545454545454545 5.2 5 2 abnormal response to infection 0.0721289072514872 0.238278895680537 0.648985722068705 0.544303797468354 5.2 5 2 decreased susceptibility to injury 0.0909830754151685 0.267024827071749 0.648763770727368 0.544117647058823 5.2 5 2 abnormal lymphocyte physiology 0.148748602277121 0.373184213983195 0.648001416120168 0.543478260869565 5.2 5 2 increased B cell proliferation 0.115201522526603 0.312671890109028 0.646683447138229 0.542372881355932 5.2 5 2 abnormal intestinal epithelium morphology 0.147934863779204 0.371329943139021 0.645841411399767 0.541666666666667 5.2 5 2 small lymph nodes 0.261476810206033 0.505686397351443 0.645841411399767 0.541666666666667 5.2 5 2 abnormal cellular extravasation 0.261476810206033 0.505686397351443 0.645841411399767 0.541666666666667 5.2 5 2 increased brown adipose tissue amount 0.192990398495058 0.432178719593789 0.644498705762762 0.540540540540541 5.2 5 2 abnormal circulating protein level 0.147054916253419 0.370054733616974 0.643854207056999 0.54 5.2 5 2 increased vascular permeability 0.191430901975803 0.432178719593789 0.642019864586751 0.538461538461538 5.2 5 2 abnormal stomach morphology 0.258394921779326 0.505686397351443 0.642019864586751 0.538461538461538 5.2 5 2 small seminal vesicle 0.258394921779326 0.505686397351443 0.642019864586751 0.538461538461538 5.2 5 2 short premaxilla 0.373302778373463 0.612988332963549 0.642019864586751 0.538461538461538 5.2 5 2 uterus hypoplasia 0.373302778373463 0.612988332963549 0.642019864586751 0.538461538461538 5.2 5 2 lymphoid hypoplasia 0.373302778373463 0.612988332963549 0.642019864586751 0.538461538461538 5.2 5 2 abnormal otolith morphology 0.373302778373463 0.612988332963549 0.642019864586751 0.538461538461538 5.2 5 2 abnormal insulin secretion 0.373302778373463 0.612988332963549 0.642019864586751 0.538461538461538 5.2 5 2 increased renin activity 0.373302778373463 0.612988332963549 0.642019864586751 0.538461538461538 5.2 5 2 increased prostaglandin level 0.373302778373463 0.612988332963549 0.642019864586751 0.538461538461538 5.2 5 2 increased neutrophil cell number 0.0290659056875167 0.126955997186476 0.641387332700459 0.537931034482759 5.2 5 2 abnormal trabecular bone morphology 0.0448437816986162 0.166242782377508 0.641249132456395 0.53781512605042 5.2 5 2 arrested B cell differentiation 0.189805169922178 0.432178719593789 0.639782861574254 0.536585365853659 5.2 5 2 decreased circulating progesterone level 0.255262891161434 0.500959717368099 0.638744253032737 0.535714285714286 5.2 5 2 abnormal CD4-positive, alpha-beta T cell physiology 0.111444327312742 0.30313588211093 0.638144493170734 0.535211267605634 5.2 5 2 abnormal blood circulation 0.188127373934723 0.432178719593789 0.637753951865244 0.534883720930233 5.2 5 2 glomerulosclerosis 0.143048936661189 0.361620152382833 0.637275875439558 0.53448275862069 5.2 5 2 interdigital webbing 0.364593188878306 0.612988332963549 0.635905389685925 0.533333333333333 5.2 5 2 arthritis 0.364593188878306 0.612988332963549 0.635905389685925 0.533333333333333 5.2 5 2 abnormal ear development 0.364593188878306 0.612988332963549 0.635905389685925 0.533333333333333 5.2 5 2 abnormal zygomatic bone morphology 0.364593188878306 0.612988332963549 0.635905389685925 0.533333333333333 5.2 5 2 liver vascular congestion 0.364593188878306 0.612988332963549 0.635905389685925 0.533333333333333 5.2 5 2 decreased brown adipose tissue mass 0.364593188878306 0.612988332963549 0.635905389685925 0.533333333333333 5.2 5 2 increased sensitivity to induced morbidity/mortality 0.0221981611645328 0.101317295223441 0.635041387797765 0.532608695652174 5.2 5 2 abnormal serotonin level 0.248946656265447 0.490308074573514 0.633421384257464 0.53125 5.2 5 2 abnormal retinal photoreceptor morphology 0.245795363131205 0.490308074573514 0.631229614761764 0.529411764705882 5.2 5 2 decreased pancreatic beta cell number 0.245795363131205 0.490308074573514 0.631229614761764 0.529411764705882 5.2 5 2 decreased osteoblast cell number 0.245795363131205 0.490308074573514 0.631229614761764 0.529411764705882 5.2 5 2 increased susceptibility to viral infection induced morbidity/mortality 0.245795363131205 0.490308074573514 0.631229614761764 0.529411764705882 5.2 5 2 abnormal inflammatory response 0.135039012591498 0.350842586790429 0.62928137521003 0.527777777777778 5.2 5 2 abnormal triglyceride level 0.348895503145317 0.612988332963549 0.627538213505847 0.526315789473684 5.2 5 2 irregular coat pigmentation 0.348895503145317 0.612988332963549 0.627538213505847 0.526315789473684 5.2 5 2 decreased germ cell number 0.348895503145317 0.612988332963549 0.627538213505847 0.526315789473684 5.2 5 2 abnormal neural crest cell migration 0.348895503145317 0.612988332963549 0.627538213505847 0.526315789473684 5.2 5 2 maternal imprinting 0.348895503145317 0.612988332963549 0.627538213505847 0.526315789473684 5.2 5 2 decreased susceptibility to weight gain 0.348895503145317 0.612988332963549 0.627538213505847 0.526315789473684 5.2 5 2 decreased circulating phosphate level 0.236485131723647 0.490308074573514 0.625969367972082 0.525 5.2 5 2 abnormal associative learning 0.341735565226772 0.612988332963549 0.624549936298676 0.523809523809524 5.2 5 2 lung inflammation 0.0723477091824321 0.238278895680537 0.622462536778961 0.522058823529412 5.2 5 2 bidirectional circling 0.334953137564687 0.611295619730124 0.622081359475361 0.521739130434783 5.2 5 2 pancreas inflammation 0.334953137564687 0.611295619730124 0.622081359475361 0.521739130434783 5.2 5 2 abnormal regulatory T cell physiology 0.334953137564687 0.611295619730124 0.622081359475361 0.521739130434783 5.2 5 2 abnormal hepatocyte physiology 0.334953137564687 0.611295619730124 0.622081359475361 0.521739130434783 5.2 5 2 ruffled hair 0.328502826348777 0.600404688128275 0.620007754943777 0.52 5.2 5 2 increased pre-B cell number 0.328502826348777 0.600404688128275 0.620007754943777 0.52 5.2 5 2 decreased acute inflammation 0.328502826348777 0.600404688128275 0.620007754943777 0.52 5.2 5 2 abnormal stomach mucosa morphology 0.328502826348777 0.600404688128275 0.620007754943777 0.52 5.2 5 2 abnormal cytokine secretion 0.0669603089681884 0.226771638609079 0.619388366577199 0.519480519480519 5.2 5 2 abnormal hair growth 0.218878872108519 0.454475120509132 0.619090583708653 0.519230769230769 5.2 5 2 focal hair loss 0.316457933890483 0.579881481070037 0.616718589135056 0.517241379310345 5.2 5 2 abnormal body temperature homeostasis 0.310807729683481 0.569737824309254 0.615392312599282 0.516129032258065 5.2 5 2 abnormal aorta morphology 0.305375811989273 0.560400097619563 0.614226796855723 0.515151515151515 5.2 5 2 thick epidermis 0.195352879330059 0.432178719593789 0.613194482911427 0.514285714285714 5.2 5 2 acanthosis 0.290218437565664 0.532781080032907 0.61144749008262 0.512820512820513 5.2 5 2 scaly skin 0.285499091615191 0.524310808706376 0.610701822411788 0.51219512195122 5.2 5 2 decreased inflammatory response 0.179266271259227 0.430429391657651 0.610355619564615 0.511904761904762 5.2 5 2 impaired macrophage phagocytosis 0.280927244265395 0.516295914377665 0.610025519175451 0.511627906976744 5.2 5 2 abnormal humoral immune response 0.182945628157708 0.432178719593789 0.601839029524179 0.504761904761905 5.2 5 2 increased eosinophil cell number 0.284857965067171 0.523326579102355 0.596161302830554 0.5 5.2 5 2 decreased IgA level 0.308998704870682 0.566630503771339 0.596161302830554 0.5 5.2 5 2 abnormal leukocyte migration 0.308998704870682 0.566630503771339 0.596161302830554 0.5 5.2 5 2 abnormal kidney physiology 0.319799368436909 0.585788607501334 0.596161302830554 0.5 5.2 5 2 abnormal systemic arterial blood pressure 0.357624300474389 0.612988332963549 0.596161302830554 0.5 5.2 5 2 underdeveloped hair follicles 0.443016711170377 0.612988332963549 0.596161302830554 0.5 5.2 5 2 waved hair 0.430464903410893 0.612988332963549 0.596161302830554 0.5 5.2 5 2 intestinal ulcer 0.418999631960647 0.612988332963549 0.596161302830554 0.5 5.2 5 2 skin edema 0.337549942389981 0.612988332963549 0.596161302830554 0.5 5.2 5 2 abnormal respiration 0.389432824430764 0.612988332963549 0.596161302830554 0.5 5.2 5 2 abnormal fibula morphology 0.430464903410893 0.612988332963549 0.596161302830554 0.5 5.2 5 2 abnormal spleen marginal zone morphology 0.380808747530311 0.612988332963549 0.596161302830554 0.5 5.2 5 2 abnormal Peyer's patch T cell area morphology 0.430464903410893 0.612988332963549 0.596161302830554 0.5 5.2 5 2 abnormal redox activity 0.443016711170377 0.612988332963549 0.596161302830554 0.5 5.2 5 2 decreased ovulation rate 0.408429464923341 0.612988332963549 0.596161302830554 0.5 5.2 5 2 abnormal circulating lipid level 0.418999631960647 0.612988332963549 0.596161302830554 0.5 5.2 5 2 decreased susceptibility to parasitic infection 0.372668803101514 0.612988332963549 0.596161302830554 0.5 5.2 5 2 abnormal mesenteric lymph node morphology 0.418999631960647 0.612988332963549 0.596161302830554 0.5 5.2 5 2 impaired humoral immune response 0.418999631960647 0.612988332963549 0.596161302830554 0.5 5.2 5 2 delayed hair appearance 0.45691805709505 0.613209423805738 0.596161302830554 0.5 5.2 5 2 abnormal intestinal absorption 0.45691805709505 0.613209423805738 0.596161302830554 0.5 5.2 5 2 sepsis 0.45691805709505 0.613209423805738 0.596161302830554 0.5 5.2 5 2 abnormal pancreatic alpha cell morphology 0.45691805709505 0.613209423805738 0.596161302830554 0.5 5.2 5 2 abnormal Langerhans cell physiology 0.45691805709505 0.613209423805738 0.596161302830554 0.5 5.2 5 2 abnormal zigzag hair morphology 0.472544102224538 0.632134151268372 0.596161302830554 0.5 5.2 5 2 absent visceral yolk sac blood islands 0.472544102224538 0.632134151268372 0.596161302830554 0.5 5.2 5 2 abnormal fluid regulation 0.472544102224538 0.632134151268372 0.596161302830554 0.5 5.2 5 2 increased lactate dehydrogenase level 0.472544102224538 0.632134151268372 0.596161302830554 0.5 5.2 5 2 abnormal imprinting 0.472544102224538 0.632134151268372 0.596161302830554 0.5 5.2 5 2 enlarged stomach 0.472544102224538 0.632134151268372 0.596161302830554 0.5 5.2 5 2 abnormal pancreas development 0.472544102224538 0.632134151268372 0.596161302830554 0.5 5.2 5 2 increased B-1 B cell number 0.472544102224538 0.632134151268372 0.596161302830554 0.5 5.2 5 2 increased stomach tumor incidence 0.472544102224538 0.632134151268372 0.596161302830554 0.5 5.2 5 2 abnormal mineral level 0.49045584739833 0.654160279036647 0.596161302830554 0.5 5.2 5 2 ear inflammation 0.49045584739833 0.654160279036647 0.596161302830554 0.5 5.2 5 2 increased litter size 0.49045584739833 0.654160279036647 0.596161302830554 0.5 5.2 5 2 increased papilloma incidence 0.49045584739833 0.654160279036647 0.596161302830554 0.5 5.2 5 2 abnormal gastrocnemius morphology 0.49045584739833 0.654160279036647 0.596161302830554 0.5 5.2 5 2 abnormal alisphenoid bone morphology 0.49045584739833 0.654160279036647 0.596161302830554 0.5 5.2 5 2 increased fear-related response 0.49045584739833 0.654160279036647 0.596161302830554 0.5 5.2 5 2 abnormal B cell proliferation 0.49045584739833 0.654160279036647 0.596161302830554 0.5 5.2 5 2 hematuria 0.49045584739833 0.654160279036647 0.596161302830554 0.5 5.2 5 2 decreased oligodendrocyte number 0.49045584739833 0.654160279036647 0.596161302830554 0.5 5.2 5 2 abnormal aorta elastic tissue morphology 0.49045584739833 0.654160279036647 0.596161302830554 0.5 5.2 5 2 absent maxillary shelf 0.511544993638671 0.679011831203946 0.596161302830554 0.5 5.2 5 2 kidney hemorrhage 0.511544993638671 0.679011831203946 0.596161302830554 0.5 5.2 5 2 abnormal respiratory mechanics 0.511544993638671 0.679011831203946 0.596161302830554 0.5 5.2 5 2 abnormal neuron specification 0.511544993638671 0.679011831203946 0.596161302830554 0.5 5.2 5 2 increased natural killer cell mediated cytotoxicity 0.511544993638671 0.679011831203946 0.596161302830554 0.5 5.2 5 2 abnormal tibialis anterior morphology 0.511544993638671 0.679011831203946 0.596161302830554 0.5 5.2 5 2 rickets 0.511544993638671 0.679011831203946 0.596161302830554 0.5 5.2 5 2 absent CD4-positive, alpha beta T cells 0.511544993638671 0.679011831203946 0.596161302830554 0.5 5.2 5 2 increased left ventricle diastolic pressure 0.511544993638671 0.679011831203946 0.596161302830554 0.5 5.2 5 2 absent coat pigmentation 0.511544993638671 0.679011831203946 0.596161302830554 0.5 5.2 5 2 ascites 0.511544993638671 0.679011831203946 0.596161302830554 0.5 5.2 5 2 absent axillary lymph nodes 0.511544993638671 0.679011831203946 0.596161302830554 0.5 5.2 5 2 crystalluria 0.511544993638671 0.679011831203946 0.596161302830554 0.5 5.2 5 2 abnormal vibrissa follicle morphology 0.511544993638671 0.679011831203946 0.596161302830554 0.5 5.2 5 2 abnormal pulmonary interalveolar septum morphology 0.511544993638671 0.679011831203946 0.596161302830554 0.5 5.2 5 2 skin lesions 0.326733530153369 0.598049783853205 0.586698425007847 0.492063492063492 5.2 5 2 abnormal intestinal mucosa morphology 0.391598881508904 0.612988332963549 0.582297086485658 0.488372093023256 5.2 5 2 abnormal response/metabolism to endogenous compounds 0.320028686777994 0.585992902731145 0.581620783249322 0.48780487804878 5.2 5 2 increased tumor growth/size 0.399620935591004 0.612988332963549 0.581620783249322 0.48780487804878 5.2 5 2 abnormal lens fiber morphology 0.408028406407898 0.612988332963549 0.580875115578489 0.487179487179487 5.2 5 2 abnormal leukocyte adhesion 0.408028406407898 0.612988332963549 0.580875115578489 0.487179487179487 5.2 5 2 skin inflammation 0.416861652399487 0.612988332963549 0.580048835186485 0.486486486486487 5.2 5 2 absent vibrissae 0.436003382971859 0.612988332963549 0.578095808805386 0.484848484848485 5.2 5 2 diarrhea 0.436003382971859 0.612988332963549 0.578095808805386 0.484848484848485 5.2 5 2 abnormal intestine physiology 0.446434701761716 0.612988332963549 0.576930293061827 0.483870967741935 5.2 5 2 stomach inflammation 0.45754272226836 0.613716646881934 0.575604016526053 0.482758620689655 5.2 5 2 abnormal CD8-positive, alpha-beta T cell physiology 0.45754272226836 0.613716646881934 0.575604016526053 0.482758620689655 5.2 5 2 cryptorchism 0.469426255960205 0.629486690943941 0.574081254577571 0.481481481481481 5.2 5 2 abnormal lymph node morphology 0.428812131307484 0.612988332963549 0.571321248545948 0.479166666666667 5.2 5 2 abnormal blood vessel physiology 0.49604225182361 0.661433986283157 0.570241246185748 0.478260869565217 5.2 5 2 abnormal cytotoxic T cell physiology 0.456049111228299 0.612988332963549 0.567772669362433 0.476190476190476 5.2 5 2 abnormal stapes morphology 0.51112793812373 0.679011831203946 0.567772669362433 0.476190476190476 5.2 5 2 increased keratinocyte proliferation 0.51112793812373 0.679011831203946 0.567772669362433 0.476190476190476 5.2 5 2 altered susceptibility to infection 0.52772579839293 0.69918398056054 0.564784392155262 0.473684210526316 5.2 5 2 abnormal response to novelty 0.52772579839293 0.69918398056054 0.564784392155262 0.473684210526316 5.2 5 2 increased circulating VLDL cholesterol level 0.52772579839293 0.69918398056054 0.564784392155262 0.473684210526316 5.2 5 2 increased susceptibility to bacterial infection induced morbidity/mortality 0.43679833120183 0.612988332963549 0.563041230451079 0.472222222222222 5.2 5 2 nephrocalcinosis 0.54618733315724 0.716016332663313 0.561092990899345 0.470588235294118 5.2 5 2 decreased IgG level 0.433128956614758 0.612988332963549 0.558565544994393 0.468468468468468 5.2 5 2 increased metastatic potential 0.524684950164153 0.695710988024164 0.556417215975184 0.466666666666667 5.2 5 2 abnormal estrous cycle 0.524684950164153 0.695710988024164 0.556417215975184 0.466666666666667 5.2 5 2 abnormal pain threshold 0.524684950164153 0.695710988024164 0.556417215975184 0.466666666666667 5.2 5 2 vagina atresia 0.56700115140249 0.738049165560207 0.556417215975184 0.466666666666667 5.2 5 2 abnormal respiratory system morphology 0.56700115140249 0.738049165560207 0.556417215975184 0.466666666666667 5.2 5 2 joint inflammation 0.56700115140249 0.738049165560207 0.556417215975184 0.466666666666667 5.2 5 2 greasy coat 0.56700115140249 0.738049165560207 0.556417215975184 0.466666666666667 5.2 5 2 lactation failure 0.56700115140249 0.738049165560207 0.556417215975184 0.466666666666667 5.2 5 2 abnormal cholesterol homeostasis 0.523332088947098 0.694472430651324 0.552539744086855 0.463414634146341 5.2 5 2 decreased Peyer's patch number 0.553862617341261 0.72588686018777 0.550302741074358 0.461538461538462 5.2 5 2 abnormal mast cell morphology 0.590872763705359 0.762144671878186 0.550302741074358 0.461538461538462 5.2 5 2 absent lateral semicircular canal 0.590872763705359 0.762144671878186 0.550302741074358 0.461538461538462 5.2 5 2 increased circulating thyroid-stimulating hormone level 0.590872763705359 0.762144671878186 0.550302741074358 0.461538461538462 5.2 5 2 decreased follicle stimulating hormone level 0.590872763705359 0.762144671878186 0.550302741074358 0.461538461538462 5.2 5 2 abnormal hair follicle inner root sheath morphology 0.590872763705359 0.762144671878186 0.550302741074358 0.461538461538462 5.2 5 2 increased autoantibody level 0.535128120464037 0.704617235060074 0.550302741074358 0.461538461538462 5.2 5 2 increased circulating total protein level 0.57017614843153 0.738049165560207 0.546481194261342 0.458333333333333 5.2 5 2 delayed wound healing 0.555012734967149 0.727202622191616 0.544321189540941 0.456521739130435 5.2 5 2 rough coat 0.587901526592965 0.759493662633083 0.541964820755049 0.454545454545455 5.2 5 2 absent semicircular canals 0.618870576106433 0.77551447054698 0.541964820755049 0.454545454545455 5.2 5 2 retinal detachment 0.618870576106433 0.77551447054698 0.541964820755049 0.454545454545455 5.2 5 2 allodynia 0.618870576106433 0.77551447054698 0.541964820755049 0.454545454545455 5.2 5 2 abnormal nerve fiber response 0.618870576106433 0.77551447054698 0.541964820755049 0.454545454545455 5.2 5 2 dilated renal glomerular capsule 0.618870576106433 0.77551447054698 0.541964820755049 0.454545454545455 5.2 5 2 pathological neovascularization 0.618870576106433 0.77551447054698 0.541964820755049 0.454545454545455 5.2 5 2 enlarged placenta 0.618870576106433 0.77551447054698 0.541964820755049 0.454545454545455 5.2 5 2 abnormal aorta smooth muscle morphology 0.618870576106433 0.77551447054698 0.541964820755049 0.454545454545455 5.2 5 2 decreased palatine bone horizontal plate size 0.618870576106433 0.77551447054698 0.541964820755049 0.454545454545455 5.2 5 2 increased subcutaneous adipose tissue amount 0.618870576106433 0.77551447054698 0.541964820755049 0.454545454545455 5.2 5 2 chylous ascites 0.618870576106433 0.77551447054698 0.541964820755049 0.454545454545455 5.2 5 2 abnormal vibrissa morphology 0.578913679236542 0.748076767325142 0.539384035894311 0.452380952380952 5.2 5 2 abnormal immune system physiology 0.574950320974537 0.743148310430845 0.538468273524372 0.451612903225806 5.2 5 2 autoimmune response 0.589126331201455 0.760878374280176 0.538468273524372 0.451612903225806 5.2 5 2 abnormal hair texture 0.607302894287325 0.77551447054698 0.536545172547499 0.45 5.2 5 2 increased urine calcium level 0.607302894287325 0.77551447054698 0.536545172547499 0.45 5.2 5 2 nuclear cataracts 0.607302894287325 0.77551447054698 0.536545172547499 0.45 5.2 5 2 polychromatophilia 0.604737975778993 0.77551447054698 0.534489443917049 0.448275862068966 5.2 5 2 increased susceptibility to parasitic infection 0.627759675781398 0.786280057153186 0.529921158071604 0.444444444444444 5.2 5 2 abnormal radius morphology 0.628723830746731 0.78689334791572 0.529921158071604 0.444444444444444 5.2 5 2 thick dermal layer 0.628723830746731 0.78689334791572 0.529921158071604 0.444444444444444 5.2 5 2 abnormal iron level 0.628723830746731 0.78689334791572 0.529921158071604 0.444444444444444 5.2 5 2 abnormal crypts of Lieberkuhn morphology 0.649485053711312 0.811003589914277 0.521641139976735 0.4375 5.2 5 2 abnormal lymphatic vessel morphology 0.649485053711312 0.811003589914277 0.521641139976735 0.4375 5.2 5 2 large intestinal inflammation 0.652621335863833 0.811003589914277 0.521641139976735 0.4375 5.2 5 2 abnormal wound healing 0.652621335863833 0.811003589914277 0.521641139976735 0.4375 5.2 5 2 abnormal level of surface class II molecules 0.652621335863833 0.811003589914277 0.521641139976735 0.4375 5.2 5 2 increased circulating estradiol level 0.652621335863833 0.811003589914277 0.521641139976735 0.4375 5.2 5 2 abnormal hair shaft morphology 0.655508791345039 0.814271220210129 0.521641139976735 0.4375 5.2 5 2 abnormal crista ampullaris morphology 0.658562507184777 0.817860327819337 0.518401132896134 0.434782608695652 5.2 5 2 abnormal immune system morphology 0.668181481960822 0.818765502181582 0.518401132896134 0.434782608695652 5.2 5 2 abnormal blood flow velocity 0.679619259815976 0.818765502181582 0.51099540242619 0.428571428571429 5.2 5 2 abnormal antigen presentation 0.679619259815976 0.818765502181582 0.51099540242619 0.428571428571429 5.2 5 2 increased vasoconstriction 0.679434111410021 0.818765502181582 0.51099540242619 0.428571428571429 5.2 5 2 decreased coping response 0.679619259815976 0.818765502181582 0.51099540242619 0.428571428571429 5.2 5 2 decreased vascular permeability 0.679619259815976 0.818765502181582 0.51099540242619 0.428571428571429 5.2 5 2 increased acute inflammation 0.679434111410021 0.818765502181582 0.51099540242619 0.428571428571429 5.2 5 2 abnormal bile salt homeostasis 0.679434111410021 0.818765502181582 0.51099540242619 0.428571428571429 5.2 5 2 abnormal respiratory motile cilium physiology 0.679619259815976 0.818765502181582 0.51099540242619 0.428571428571429 5.2 5 2 abnormal leukocyte cell number 0.701943780277046 0.818765502181582 0.504444179318162 0.423076923076923 5.2 5 2 osteoarthritis 0.702176945185859 0.818765502181582 0.502030570804678 0.421052631578947 5.2 5 2 impaired natural killer cell mediated cytotoxicity 0.746201034740302 0.865270857272088 0.502030570804678 0.421052631578947 5.2 5 2 abnormal T cell proliferation 0.721442363930681 0.837223177176379 0.500006253986917 0.419354838709677 5.2 5 2 decreased susceptibility to bacterial infection induced morbidity/mortality 0.721442363930681 0.837223177176379 0.500006253986917 0.419354838709677 5.2 5 2 abnormal glossopharyngeal nerve morphology 0.710595382326507 0.825020309702304 0.496801085692129 0.416666666666667 5.2 5 2 increased urine phosphate level 0.710595382326507 0.825020309702304 0.496801085692129 0.416666666666667 5.2 5 2 absent tail 0.710595382326507 0.825020309702304 0.496801085692129 0.416666666666667 5.2 5 2 decreased circulating ketone body level 0.710595382326507 0.825020309702304 0.496801085692129 0.416666666666667 5.2 5 2 hemoperitoneum 0.710595382326507 0.825020309702304 0.496801085692129 0.416666666666667 5.2 5 2 decreased compensatory feeding amount 0.710595382326507 0.825020309702304 0.496801085692129 0.416666666666667 5.2 5 2 increased susceptibility to induced arthritis 0.738934773019267 0.85712298805569 0.493374871308045 0.413793103448276 5.2 5 2 enlarged sebaceous gland 0.727125137758447 0.843621166125997 0.490956367036927 0.411764705882353 5.2 5 2 abnormal aorta wall morphology 0.754697998758299 0.867920144203084 0.476929042264444 0.4 5.2 5 2 decreased skin tensile strength 0.765426312451549 0.880054519169507 0.476929042264444 0.4 5.2 5 2 salivary gland inflammation 0.787587958120905 0.903384171749128 0.476929042264444 0.4 5.2 5 2 abnormal stria vascularis morphology 0.805130151001324 0.920175166834732 0.468412452224007 0.392857142857143 5.2 5 2 impaired leukocyte tethering or rolling 0.789744151311357 0.903384171749128 0.463681013312653 0.388888888888889 5.2 5 2 abnormal membranous labyrinth morphology 0.785422018964724 0.902419063360163 0.458585617561965 0.384615384615385 5.2 5 2 abnormal renal/urinary system morphology 0.785422018964724 0.902419063360163 0.458585617561965 0.384615384615385 5.2 5 2 abnormal sympathetic ganglion morphology 0.785422018964724 0.902419063360163 0.458585617561965 0.384615384615385 5.2 5 2 abnormal tectorial membrane morphology 0.823308880776322 0.93601551477034 0.458585617561965 0.384615384615385 5.2 5 2 abnormal circulating glucose level 0.845582881990359 0.937338421992432 0.452260298699041 0.379310344827586 5.2 5 2 mixed cellular infiltration to dermis 0.81594399649498 0.931891961102508 0.447120977122916 0.375 5.2 5 2 abnormal intestinal lipid absorption 0.81594399649498 0.931891961102508 0.447120977122916 0.375 5.2 5 2 abnormal fertilization 0.81594399649498 0.931891961102508 0.447120977122916 0.375 5.2 5 2 abnormal feces composition 0.878949266326912 0.971727244439197 0.429236138037999 0.36 5.2 5 2 abnormal hair cuticle 0.844201329602917 0.93601551477034 0.425829502021825 0.357142857142857 5.2 5 2 abnormal renal reabsorbtion 0.844201329602917 0.93601551477034 0.425829502021825 0.357142857142857 5.2 5 2 abnormal spleen germinal center morphology 0.893799691198189 0.987706233609727 0.425829502021825 0.357142857142857 5.2 5 2 abnormal tendon morphology 0.864390646714907 0.956694875952539 0.420819743174509 0.352941176470588 5.2 5 2 decreased circulating VLDL cholesterol level 0.88142432645106 0.974247061562769 0.417312911981388 0.35 5.2 5 2 hypoalgesia 0.912964194668807 0.996926441720218 0.397440868553703 0.333333333333333 5.2 5 2 decreased airway responsiveness 0.936975539229682 1 0.379375374528535 0.318181818181818 5.2 5 2 increased susceptibility to fungal infection 0.954928537971559 1 0.362880793027294 0.304347826086957 5.2 5 2 abnormal circulating cytokine level 0.950555933126422 1 0.357696781698333 0.3 5.2 5 2 abnormal fear/anxiety-related behavior 8.21746959130406e-05 0.00107583976886152 1.35126143609648 1 5.6 5 6 fatigue 8.21746959130406e-05 0.00107583976886152 1.35126143609648 1 5.6 5 6 abnormal spinal cord dorsal column morphology 0.0001932912080174 0.00229103712494386 1.35126143609648 1 5.6 5 6 abnormal kindling response 0.000454641190090166 0.00480220789957235 1.35126143609648 1 5.6 5 6 abnormal NMDA-mediated synaptic currents 0.000454641190090166 0.00480220789957235 1.35126143609648 1 5.6 5 6 increased neuronal precursor cell number 0.000454641190090166 0.00480220789957235 1.35126143609648 1 5.6 5 6 decreased aerobic running capacity 0.00106932112365451 0.00956811616939065 1.35126143609648 1 5.6 5 6 craniofacial phenotype 0.00106932112365451 0.00956811616939065 1.35126143609648 1 5.6 5 6 abnormal base-excision repair 0.00106932112365451 0.00956811616939065 1.35126143609648 1 5.6 5 6 abnormal olfactory bulb glomerular layer morphology 0.00106932112365451 0.00956811616939065 1.35126143609648 1 5.6 5 6 abnormal cerebellum deep nucleus morphology 0.00106932112365451 0.00956811616939065 1.35126143609648 1 5.6 5 6 lung situs inversus 0.00106932112365451 0.00956811616939065 1.35126143609648 1 5.6 5 6 decreased alveolar lamellar body number 0.00106932112365451 0.00956811616939065 1.35126143609648 1 5.6 5 6 embryo cyst 0.00106932112365451 0.00956811616939065 1.35126143609648 1 5.6 5 6 increased brain apoptosis 0.00106932112365451 0.00956811616939065 1.35126143609648 1 5.6 5 6 abnormal tooth eruption 0.0139098479161985 0.0707581731933409 1.35126143609648 1 5.6 5 6 small hair follicles 0.0139098479161985 0.0707581731933409 1.35126143609648 1 5.6 5 6 abnormal pulmonary trunk morphology 0.0139098479161985 0.0707581731933409 1.35126143609648 1 5.6 5 6 abnormal pineal gland morphology 0.0139098479161985 0.0707581731933409 1.35126143609648 1 5.6 5 6 optic nerve atrophy 0.0139098479161985 0.0707581731933409 1.35126143609648 1 5.6 5 6 absent prostate gland 0.0139098479161985 0.0707581731933409 1.35126143609648 1 5.6 5 6 skin hyperplasia 0.0139098479161985 0.0707581731933409 1.35126143609648 1 5.6 5 6 kinked vibrissae 0.0139098479161985 0.0707581731933409 1.35126143609648 1 5.6 5 6 increased hepatic hemangioma incidence 0.0139098479161985 0.0707581731933409 1.35126143609648 1 5.6 5 6 cerebral aqueductal stenosis 0.0139098479161985 0.0707581731933409 1.35126143609648 1 5.6 5 6 decreased lysosomal enzyme secretion 0.0139098479161985 0.0707581731933409 1.35126143609648 1 5.6 5 6 increased lysosomal enzyme secretion 0.0139098479161985 0.0707581731933409 1.35126143609648 1 5.6 5 6 enhanced NMDA-mediated synaptic currents 0.0139098479161985 0.0707581731933409 1.35126143609648 1 5.6 5 6 gastric polyps 0.0139098479161985 0.0707581731933409 1.35126143609648 1 5.6 5 6 sirenomelia 0.0139098479161985 0.0707581731933409 1.35126143609648 1 5.6 5 6 thyroid hypoplasia 0.0139098479161985 0.0707581731933409 1.35126143609648 1 5.6 5 6 scapular bone foramen 0.0139098479161985 0.0707581731933409 1.35126143609648 1 5.6 5 6 abnormal iris stroma morphology 0.0139098479161985 0.0707581731933409 1.35126143609648 1 5.6 5 6 corneal deposits 0.0139098479161985 0.0707581731933409 1.35126143609648 1 5.6 5 6 abnormal hemoglobin content 0.0139098479161985 0.0707581731933409 1.35126143609648 1 5.6 5 6 enlarged eye anterior chamber 0.0139098479161985 0.0707581731933409 1.35126143609648 1 5.6 5 6 increased response to stress-induced hyperthermia 0.0139098479161985 0.0707581731933409 1.35126143609648 1 5.6 5 6 increased mammary gland epithelial cell proliferation 0.0139098479161985 0.0707581731933409 1.35126143609648 1 5.6 5 6 increased thyroid carcinoma incidence 0.0139098479161985 0.0707581731933409 1.35126143609648 1 5.6 5 6 aorta hypoplasia 0.0139098479161985 0.0707581731933409 1.35126143609648 1 5.6 5 6 midface hypoplasia 0.0139098479161985 0.0707581731933409 1.35126143609648 1 5.6 5 6 abnormal ciliary process morphology 0.0139098479161985 0.0707581731933409 1.35126143609648 1 5.6 5 6 decreased neuronal precursor proliferation 0.0139098479161985 0.0707581731933409 1.35126143609648 1 5.6 5 6 embryonic lethality between implantation and placentation, incomplete penetrance 3.49338775979214e-05 0.000523482051354395 1.35126143609648 1 5.6 5 6 broad head 0.00251495489570696 0.0189287452437854 1.35126143609648 1 5.6 5 6 decreased Schwann cell number 0.00251495489570696 0.0189287452437854 1.35126143609648 1 5.6 5 6 abnormal brain ventricular system morphology 0.00251495489570696 0.0189287452437854 1.35126143609648 1 5.6 5 6 decreased cardiomyocyte apoptosis 0.00251495489570696 0.0189287452437854 1.35126143609648 1 5.6 5 6 aorta coarctation 0.00251495489570696 0.0189287452437854 1.35126143609648 1 5.6 5 6 increased cell nucleus count 0.00251495489570696 0.0189287452437854 1.35126143609648 1 5.6 5 6 abnormal optic tract morphology 0.00251495489570696 0.0189287452437854 1.35126143609648 1 5.6 5 6 heart hemorrhage 0.00251495489570696 0.0189287452437854 1.35126143609648 1 5.6 5 6 decreased brain cholesterol level 0.00251495489570696 0.0189287452437854 1.35126143609648 1 5.6 5 6 abnormal outer hair cell kinocilium morphology 0.00251495489570696 0.0189287452437854 1.35126143609648 1 5.6 5 6 thin tail 0.00591473028377401 0.0370910758979354 1.35126143609648 1 5.6 5 6 delayed brain development 0.00591473028377401 0.0370910758979354 1.35126143609648 1 5.6 5 6 chromatolysis 0.00591473028377401 0.0370910758979354 1.35126143609648 1 5.6 5 6 increased post-tetanic potentiation 0.00591473028377401 0.0370910758979354 1.35126143609648 1 5.6 5 6 abnormal hippocampal fimbria morphology 0.00591473028377401 0.0370910758979354 1.35126143609648 1 5.6 5 6 abnormal intestinal peristalsis 0.00591473028377401 0.0370910758979354 1.35126143609648 1 5.6 5 6 ureter obstruction 0.00591473028377401 0.0370910758979354 1.35126143609648 1 5.6 5 6 short scapula 0.00591473028377401 0.0370910758979354 1.35126143609648 1 5.6 5 6 decreased prostate gland weight 0.00591473028377401 0.0370910758979354 1.35126143609648 1 5.6 5 6 decreased platelet ADP level 0.00591473028377401 0.0370910758979354 1.35126143609648 1 5.6 5 6 abnormal eyelid development 0.00591473028377401 0.0370910758979354 1.35126143609648 1 5.6 5 6 ectopic hippocampus pyramidal cells 0.00591473028377401 0.0370910758979354 1.35126143609648 1 5.6 5 6 myocardium hypoplasia 0.00591473028377401 0.0370910758979354 1.35126143609648 1 5.6 5 6 ciliary body hypoplasia 0.00591473028377401 0.0370910758979354 1.35126143609648 1 5.6 5 6 abnormal vertebral artery origin 0.00591473028377401 0.0370910758979354 1.35126143609648 1 5.6 5 6 abnormal Wolffian duct connection 0.00591473028377401 0.0370910758979354 1.35126143609648 1 5.6 5 6 decreased hippocampus volume 0.00591473028377401 0.0370910758979354 1.35126143609648 1 5.6 5 6 abnormal excitatory synapse morphology 0.00591473028377401 0.0370910758979354 1.35126143609648 1 5.6 5 6 decreased paired-pulse facilitation 1.04422417497273e-06 2.39401625368173e-05 1.28369836429166 0.95 5.6 5 6 impaired synaptic plasticity 2.49947860100045e-10 1.20727243106575e-08 1.27177546926727 0.941176470588235 5.6 5 6 absence seizures 1.16328577515065e-05 0.000198877894548952 1.27177546926727 0.941176470588235 5.6 5 6 increased cochlear outer hair cell number 2.5824757141082e-05 0.000405293901504362 1.26680759634045 0.9375 5.6 5 6 dystonia 2.5824757141082e-05 0.000405293901504362 1.26680759634045 0.9375 5.6 5 6 abnormal synaptic transmission 5.98686848668914e-09 2.27363898635713e-07 1.26117734035671 0.933333333333333 5.6 5 6 midline facial cleft 0.000125841060946391 0.0015690708727025 1.25474276208959 0.928571428571429 5.6 5 6 absent olfactory bulb 0.000125841060946391 0.0015690708727025 1.25474276208959 0.928571428571429 5.6 5 6 lysosomal protein accumulation 0.000125841060946391 0.0015690708727025 1.25474276208959 0.928571428571429 5.6 5 6 multiple persisting craniopharyngeal ducts 0.000125841060946391 0.0015690708727025 1.25474276208959 0.928571428571429 5.6 5 6 abnormal vitelline vein topology 0.000125841060946391 0.0015690708727025 1.25474276208959 0.928571428571429 5.6 5 6 abnormal grip strength 0.000275935603588395 0.0031089943061253 1.24731824870444 0.923076923076923 5.6 5 6 axonal dystrophy 0.000275935603588395 0.0031089943061253 1.24731824870444 0.923076923076923 5.6 5 6 increased cochlear inner hair cell number 0.000275935603588395 0.0031089943061253 1.24731824870444 0.923076923076923 5.6 5 6 abnormal nest building behavior 3.01280850767339e-07 7.64730730901791e-06 1.24316052120876 0.92 5.6 5 6 abnormal corticospinal tract morphology 0.000601823697379354 0.00590546921984672 1.23865631642177 0.916666666666667 5.6 5 6 abnormal AMPA-mediated synaptic currents 0.000601823697379354 0.00590546921984672 1.23865631642177 0.916666666666667 5.6 5 6 decreased synaptic depression 0.000601823697379354 0.00590546921984672 1.23865631642177 0.916666666666667 5.6 5 6 decreased mammary gland epithelial cell proliferation 0.000601823697379354 0.00590546921984672 1.23865631642177 0.916666666666667 5.6 5 6 social withdrawal 0.00130445632906099 0.0112667886060389 1.22841948736044 0.909090909090909 5.6 5 6 abnormal proximal-distal axis patterning 0.00130445632906099 0.0112667886060389 1.22841948736044 0.909090909090909 5.6 5 6 abnormal spinal cord ventral horn morphology 0.00130445632906099 0.0112667886060389 1.22841948736044 0.909090909090909 5.6 5 6 reduced sympathetic cervical ganglion size 0.00130445632906099 0.0112667886060389 1.22841948736044 0.909090909090909 5.6 5 6 abnormal embryonic/fetal subventricular zone morphology 6.54508008314592e-06 0.000121954207541764 1.22256987075396 0.904761904761905 5.6 5 6 abnormal cell differentiation 2.13672456941256e-10 1.05249551810173e-08 1.21943105208707 0.902439024390244 5.6 5 6 anencephaly 1.39866959800181e-05 0.000233502726512047 1.21613529248683 0.9 5.6 5 6 increased skin tumor incidence 1.39866959800181e-05 0.000233502726512047 1.21613529248683 0.9 5.6 5 6 fused cornea and lens 0.00280679102874507 0.0204747586041154 1.21613529248683 0.9 5.6 5 6 absent seminal vesicle 0.00280679102874507 0.0204747586041154 1.21613529248683 0.9 5.6 5 6 abnormal plasma membrane morphology 0.00280679102874507 0.0204747586041154 1.21613529248683 0.9 5.6 5 6 tachypnea 0.00280679102874507 0.0204747586041154 1.21613529248683 0.9 5.6 5 6 decreased transitional stage T2 B cell number 0.00280679102874507 0.0204747586041154 1.21613529248683 0.9 5.6 5 6 abnormal hippocampus neuron morphology 0.00280679102874507 0.0204747586041154 1.21613529248683 0.9 5.6 5 6 abnormal cerebellar granule cell migration 0.00280679102874507 0.0204747586041154 1.21613529248683 0.9 5.6 5 6 lethality during fetal growth through weaning, complete penetrance 0.00280679102874507 0.0204747586041154 1.21613529248683 0.9 5.6 5 6 absent corpus callosum 3.50200435600196e-07 8.58249836015258e-06 1.20648342508614 0.892857142857143 5.6 5 6 abnormal brainstem morphology 3.50200435600196e-07 8.58249836015258e-06 1.20648342508614 0.892857142857143 5.6 5 6 abnormal contextual conditioning behavior 7.04553321535515e-13 4.87024006477417e-11 1.20385109761323 0.890909090909091 5.6 5 6 decreased pulmonary respiratory rate 6.29100775045539e-05 0.000850482705394444 1.2011212765302 0.888888888888889 5.6 5 6 small thoracic cage 6.29100775045539e-05 0.000850482705394444 1.2011212765302 0.888888888888889 5.6 5 6 abnormal hypoglossal nerve topology 6.29100775045539e-05 0.000850482705394444 1.2011212765302 0.888888888888889 5.6 5 6 heart hyperplasia 0.00598676059216927 0.0370910758979354 1.2011212765302 0.888888888888889 5.6 5 6 abnormal vomeronasal organ morphology 0.00598676059216927 0.0370910758979354 1.2011212765302 0.888888888888889 5.6 5 6 pancreas cysts 0.00598676059216927 0.0370910758979354 1.2011212765302 0.888888888888889 5.6 5 6 decreased fear-related response 0.00598676059216927 0.0370910758979354 1.2011212765302 0.888888888888889 5.6 5 6 decreased cellular sensitivity to ionizing radiation 0.00598676059216927 0.0370910758979354 1.2011212765302 0.888888888888889 5.6 5 6 liver hyperplasia 0.00598676059216927 0.0370910758979354 1.2011212765302 0.888888888888889 5.6 5 6 enhanced conditioned place preference behavior 0.00598676059216927 0.0370910758979354 1.2011212765302 0.888888888888889 5.6 5 6 decreased transitional stage T1 B cell number 0.00598676059216927 0.0370910758979354 1.2011212765302 0.888888888888889 5.6 5 6 abnormal hippocampus granule cell morphology 0.00598676059216927 0.0370910758979354 1.2011212765302 0.888888888888889 5.6 5 6 abnormal cerebellar layer morphology 0.00598676059216927 0.0370910758979354 1.2011212765302 0.888888888888889 5.6 5 6 axonal spheroids 0.00598676059216927 0.0370910758979354 1.2011212765302 0.888888888888889 5.6 5 6 abnormal ventricle myocardium morphology 0.00598676059216927 0.0370910758979354 1.2011212765302 0.888888888888889 5.6 5 6 shortened ST segment 0.00598676059216927 0.0370910758979354 1.2011212765302 0.888888888888889 5.6 5 6 fusion of atlas and occipital bones 0.00598676059216927 0.0370910758979354 1.2011212765302 0.888888888888889 5.6 5 6 decreased effector memory CD4-positive, alpha-beta T cell number 0.00598676059216927 0.0370910758979354 1.2011212765302 0.888888888888889 5.6 5 6 reduced AMPA-mediated synaptic currents 0.00598676059216927 0.0370910758979354 1.2011212765302 0.888888888888889 5.6 5 6 increased core body temperature 0.00598676059216927 0.0370910758979354 1.2011212765302 0.888888888888889 5.6 5 6 decreased platelet dense granule number 0.00598676059216927 0.0370910758979354 1.2011212765302 0.888888888888889 5.6 5 6 increased intestinal adenocarcinoma incidence 0.000276216177549222 0.0031089943061253 1.18235375658442 0.875 5.6 5 6 abnormal exoccipital bone morphology 0.0126343913000741 0.0684706935924497 1.18235375658442 0.875 5.6 5 6 pointed snout 0.0126343913000741 0.0684706935924497 1.18235375658442 0.875 5.6 5 6 increased sensitivity to skin irradiation 0.0126343913000741 0.0684706935924497 1.18235375658442 0.875 5.6 5 6 poor grooming 0.0126343913000741 0.0684706935924497 1.18235375658442 0.875 5.6 5 6 preneoplasia 0.0126343913000741 0.0684706935924497 1.18235375658442 0.875 5.6 5 6 short ureter 0.0126343913000741 0.0684706935924497 1.18235375658442 0.875 5.6 5 6 abnormal neuron apoptosis 0.0126343913000741 0.0684706935924497 1.18235375658442 0.875 5.6 5 6 colon polyps 0.0126343913000741 0.0684706935924497 1.18235375658442 0.875 5.6 5 6 liver cysts 0.0126343913000741 0.0684706935924497 1.18235375658442 0.875 5.6 5 6 increased cardiac output 0.0126343913000741 0.0684706935924497 1.18235375658442 0.875 5.6 5 6 absent interparietal bone 0.0126343913000741 0.0684706935924497 1.18235375658442 0.875 5.6 5 6 abnormal kidney epithelium morphology 0.0126343913000741 0.0684706935924497 1.18235375658442 0.875 5.6 5 6 accumulation of giant lysosomes in kidney/renal tubule cells 0.0126343913000741 0.0684706935924497 1.18235375658442 0.875 5.6 5 6 abnormal choroid pigmentation 0.0126343913000741 0.0684706935924497 1.18235375658442 0.875 5.6 5 6 abnormal olfactory tract morphology 0.0126343913000741 0.0684706935924497 1.18235375658442 0.875 5.6 5 6 abnormal meiotic spindle morphology 0.0126343913000741 0.0684706935924497 1.18235375658442 0.875 5.6 5 6 abnormal mitotic spindle assembly checkpoint 0.0126343913000741 0.0684706935924497 1.18235375658442 0.875 5.6 5 6 abnormal olfactory bulb mitral cell layer morphology 0.0126343913000741 0.0684706935924497 1.18235375658442 0.875 5.6 5 6 decreased hippocampus pyramidal cell number 0.0126343913000741 0.0684706935924497 1.18235375658442 0.875 5.6 5 6 pleural effusion 0.0126343913000741 0.0684706935924497 1.18235375658442 0.875 5.6 5 6 abnormal visual evoked potential 0.0126343913000741 0.0684706935924497 1.18235375658442 0.875 5.6 5 6 abnormal anterior commissure pars posterior morphology 0.0126343913000741 0.0684706935924497 1.18235375658442 0.875 5.6 5 6 abnormal heart echocardiography feature 0.0126343913000741 0.0684706935924497 1.18235375658442 0.875 5.6 5 6 increased cardiac stroke volume 0.0126343913000741 0.0684706935924497 1.18235375658442 0.875 5.6 5 6 absent hypoglossal canal 0.0126343913000741 0.0684706935924497 1.18235375658442 0.875 5.6 5 6 retropleural edema 0.0126343913000741 0.0684706935924497 1.18235375658442 0.875 5.6 5 6 abnormal umbilical vein topology 0.0126343913000741 0.0684706935924497 1.18235375658442 0.875 5.6 5 6 abnormal object recognition memory 3.56940206273814e-07 8.70479179515798e-06 1.17690512176145 0.870967741935484 5.6 5 6 abnormal nasal cavity morphology 1.39452230960057e-05 0.000233502726512047 1.17500994443172 0.869565217391304 5.6 5 6 abnormal response to new environment 7.34635496215201e-07 1.73213819605243e-05 1.17109324461695 0.866666666666667 5.6 5 6 decreased hepatocyte number 0.00057250400659929 0.00571929203379812 1.17109324461695 0.866666666666667 5.6 5 6 abnormal placenta size 0.00057250400659929 0.00571929203379812 1.17109324461695 0.866666666666667 5.6 5 6 immune system phenotype 0.00057250400659929 0.00571929203379812 1.17109324461695 0.866666666666667 5.6 5 6 heterochrony 0.00057250400659929 0.00571929203379812 1.17109324461695 0.866666666666667 5.6 5 6 decreased brown adipose tissue mass 0.00057250400659929 0.00571929203379812 1.17109324461695 0.866666666666667 5.6 5 6 abnormal brain wave pattern 5.90589992781946e-11 3.15933893988192e-09 1.16936085816041 0.865384615384615 5.6 5 6 abnormal tail movements 2.86857695654189e-05 0.000443204048409811 1.16699851299241 0.863636363636364 5.6 5 6 abnormal lysosome physiology 2.86857695654189e-05 0.000443204048409811 1.16699851299241 0.863636363636364 5.6 5 6 abnormal cued conditioning behavior 1.20681387871342e-10 6.25406150687422e-09 1.16579418016167 0.862745098039216 5.6 5 6 absent long term depression 1.50494193258056e-06 3.31286996220721e-05 1.16488054835903 0.862068965517241 5.6 5 6 abnormal lysosome morphology 8.10481146769697e-08 2.24007983621069e-06 1.16358623663863 0.861111111111111 5.6 5 6 absent segment of posterior cerebral artery 5.86363913612509e-05 0.000817131784375976 1.1582240880827 0.857142857142857 5.6 5 6 increased hemangioma incidence 0.00117650285944041 0.0103778399392128 1.1582240880827 0.857142857142857 5.6 5 6 abnormal viscerocranium morphology 0.00117650285944041 0.0103778399392128 1.1582240880827 0.857142857142857 5.6 5 6 maxilla hypoplasia 0.0263133826121762 0.117302041662703 1.1582240880827 0.857142857142857 5.6 5 6 abnormal oculomotor nerve morphology 0.0263133826121762 0.117302041662703 1.1582240880827 0.857142857142857 5.6 5 6 retina hyperplasia 0.0263133826121762 0.117302041662703 1.1582240880827 0.857142857142857 5.6 5 6 abnormal circulating alanine transaminase level 0.0263133826121762 0.117302041662703 1.1582240880827 0.857142857142857 5.6 5 6 abnormal tumor incidence 0.0263133826121762 0.117302041662703 1.1582240880827 0.857142857142857 5.6 5 6 abnormal gastrulation movements 0.0263133826121762 0.117302041662703 1.1582240880827 0.857142857142857 5.6 5 6 abnormal adrenal gland physiology 0.0263133826121762 0.117302041662703 1.1582240880827 0.857142857142857 5.6 5 6 increased retinal ganglion cell number 0.0263133826121762 0.117302041662703 1.1582240880827 0.857142857142857 5.6 5 6 decreased mortality induced by ionizing radiation 0.0263133826121762 0.117302041662703 1.1582240880827 0.857142857142857 5.6 5 6 absent tunnel of Corti 0.0263133826121762 0.117302041662703 1.1582240880827 0.857142857142857 5.6 5 6 increased ectoderm apoptosis 0.0263133826121762 0.117302041662703 1.1582240880827 0.857142857142857 5.6 5 6 decreased tidal volume 0.0263133826121762 0.117302041662703 1.1582240880827 0.857142857142857 5.6 5 6 abnormal spinal cord central canal morphology 0.0263133826121762 0.117302041662703 1.1582240880827 0.857142857142857 5.6 5 6 abnormal cerebellum white matter morphology 0.0263133826121762 0.117302041662703 1.1582240880827 0.857142857142857 5.6 5 6 increased oligodendrocyte number 0.0263133826121762 0.117302041662703 1.1582240880827 0.857142857142857 5.6 5 6 abnormal retina inner limiting membrane morphology 0.0263133826121762 0.117302041662703 1.1582240880827 0.857142857142857 5.6 5 6 long stride length 0.0263133826121762 0.117302041662703 1.1582240880827 0.857142857142857 5.6 5 6 abnormal aortic valve cusp morphology 0.0263133826121762 0.117302041662703 1.1582240880827 0.857142857142857 5.6 5 6 abnormal brain ependyma motile cilium physiology 0.0263133826121762 0.117302041662703 1.1582240880827 0.857142857142857 5.6 5 6 embryonic lethality at implantation, incomplete penetrance 0.0263133826121762 0.117302041662703 1.1582240880827 0.857142857142857 5.6 5 6 ductus venosus stenosis 0.0263133826121762 0.117302041662703 1.1582240880827 0.857142857142857 5.6 5 6 embryo tumor 0.0263133826121762 0.117302041662703 1.1582240880827 0.857142857142857 5.6 5 6 abnormal hearing physiology 0.000119031680519975 0.00150682598113709 1.14857222068201 0.85 5.6 5 6 failure to gastrulate 4.10162029022589e-09 1.58182642975766e-07 1.14563469582093 0.847826086956522 5.6 5 6 excessive scratching 0.00239420821322963 0.0186695703147608 1.14337506131241 0.846153846153846 5.6 5 6 abnormal lung interstitium morphology 0.00239420821322963 0.0186695703147608 1.14337506131241 0.846153846153846 5.6 5 6 abnormal coping response 0.00239420821322963 0.0186695703147608 1.14337506131241 0.846153846153846 5.6 5 6 abnormal afterhyperpolarization 0.00239420821322963 0.0186695703147608 1.14337506131241 0.846153846153846 5.6 5 6 abnormal vertebral arch development 0.00239420821322963 0.0186695703147608 1.14337506131241 0.846153846153846 5.6 5 6 decreased cardiac stroke volume 0.00239420821322963 0.0186695703147608 1.14337506131241 0.846153846153846 5.6 5 6 absent hypoglossal nerve 0.00239420821322963 0.0186695703147608 1.14337506131241 0.846153846153846 5.6 5 6 abnormal blastocyst morphology 0.00023979879133678 0.00277441624860577 1.13790436723914 0.842105263157895 5.6 5 6 right-sided stomach 0.00023979879133678 0.00277441624860577 1.13790436723914 0.842105263157895 5.6 5 6 abnormal breathing pattern 2.94860598125565e-07 7.56150245193138e-06 1.13213795997273 0.837837837837838 5.6 5 6 abnormal cell cycle 1.50868083082371e-19 2.34552722917124e-17 1.12800954665445 0.834782608695652 5.6 5 6 abnormal nervous system electrophysiology 1.51231855445917e-14 1.31996224709375e-12 1.12605119674707 0.833333333333333 5.6 5 6 abnormal excitatory postsynaptic currents 1.32621809695105e-13 1.01506692805099e-11 1.12605119674707 0.833333333333333 5.6 5 6 impaired limb coordination 8.05473196665932e-10 3.48454708992436e-08 1.12605119674707 0.833333333333333 5.6 5 6 neurodegeneration 8.05473196665932e-10 3.48454708992436e-08 1.12605119674707 0.833333333333333 5.6 5 6 small heart 7.18458862053996e-09 2.6090020720574e-07 1.12605119674707 0.833333333333333 5.6 5 6 vertebral transformation 7.18458862053996e-09 2.6090020720574e-07 1.12605119674707 0.833333333333333 5.6 5 6 reduced long term depression 5.84290053773098e-07 1.40365511650039e-05 1.12605119674707 0.833333333333333 5.6 5 6 abnormal brain vasculature morphology 5.35647411440738e-06 0.000102494071996834 1.12605119674707 0.833333333333333 5.6 5 6 ocular hypertelorism 4.99701212095478e-05 0.000702263709088984 1.12605119674707 0.833333333333333 5.6 5 6 absent spleen 0.000479033627854616 0.00498575794681321 1.12605119674707 0.833333333333333 5.6 5 6 decreased lactate dehydrogenase level 0.000479033627854616 0.00498575794681321 1.12605119674707 0.833333333333333 5.6 5 6 primary atelectasis 0.000479033627854616 0.00498575794681321 1.12605119674707 0.833333333333333 5.6 5 6 abnormal adipose tissue distribution 0.00481761948746916 0.0318718842422328 1.12605119674707 0.833333333333333 5.6 5 6 absent ovary 0.00481761948746916 0.0318718842422328 1.12605119674707 0.833333333333333 5.6 5 6 abnormal amacrine cell morphology 0.00481761948746916 0.0318718842422328 1.12605119674707 0.833333333333333 5.6 5 6 abnormal vitelline vein connection 0.00481761948746916 0.0318718842422328 1.12605119674707 0.833333333333333 5.6 5 6 hyperresponsive 0.0538854360783208 0.192309931484681 1.12605119674707 0.833333333333333 5.6 5 6 jumpy 0.0538854360783208 0.192309931484681 1.12605119674707 0.833333333333333 5.6 5 6 abnormal avoidance learning behavior 0.0538854360783208 0.192309931484681 1.12605119674707 0.833333333333333 5.6 5 6 absent ectoplacental cone 0.0538854360783208 0.192309931484681 1.12605119674707 0.833333333333333 5.6 5 6 non-obstructive hydrocephaly 0.0538854360783208 0.192309931484681 1.12605119674707 0.833333333333333 5.6 5 6 reduced NMDA-mediated synaptic currents 0.0538854360783208 0.192309931484681 1.12605119674707 0.833333333333333 5.6 5 6 abnormal parental behavior 0.0538854360783208 0.192309931484681 1.12605119674707 0.833333333333333 5.6 5 6 abnormal internal nares morphology 0.0538854360783208 0.192309931484681 1.12605119674707 0.833333333333333 5.6 5 6 abnormal pulmonary ventilation 0.0538854360783208 0.192309931484681 1.12605119674707 0.833333333333333 5.6 5 6 abnormal cervical lymph node morphology 0.0538854360783208 0.192309931484681 1.12605119674707 0.833333333333333 5.6 5 6 decreased posterior semicircular canal size 0.0538854360783208 0.192309931484681 1.12605119674707 0.833333333333333 5.6 5 6 calcified joint 0.0538854360783208 0.192309931484681 1.12605119674707 0.833333333333333 5.6 5 6 loss of hippocampal neurons 0.0538854360783208 0.192309931484681 1.12605119674707 0.833333333333333 5.6 5 6 decreased liver function 0.0538854360783208 0.192309931484681 1.12605119674707 0.833333333333333 5.6 5 6 increased glycerol level 0.0538854360783208 0.192309931484681 1.12605119674707 0.833333333333333 5.6 5 6 enlarged pancreas 0.0538854360783208 0.192309931484681 1.12605119674707 0.833333333333333 5.6 5 6 matted coat 0.0538854360783208 0.192309931484681 1.12605119674707 0.833333333333333 5.6 5 6 abnormal cholesterol level 0.0538854360783208 0.192309931484681 1.12605119674707 0.833333333333333 5.6 5 6 abnormal extensor digitorum longus morphology 0.0538854360783208 0.192309931484681 1.12605119674707 0.833333333333333 5.6 5 6 absent parietal bone 0.0538854360783208 0.192309931484681 1.12605119674707 0.833333333333333 5.6 5 6 abnormal common crus morphology 0.0538854360783208 0.192309931484681 1.12605119674707 0.833333333333333 5.6 5 6 abnormal blastocoele morphology 0.0538854360783208 0.192309931484681 1.12605119674707 0.833333333333333 5.6 5 6 osteomyelitis 0.0538854360783208 0.192309931484681 1.12605119674707 0.833333333333333 5.6 5 6 abnormal ligament morphology 0.0538854360783208 0.192309931484681 1.12605119674707 0.833333333333333 5.6 5 6 abnormal neural crest cell morphology 0.0538854360783208 0.192309931484681 1.12605119674707 0.833333333333333 5.6 5 6 exostosis 0.0538854360783208 0.192309931484681 1.12605119674707 0.833333333333333 5.6 5 6 absent tongue 0.0538854360783208 0.192309931484681 1.12605119674707 0.833333333333333 5.6 5 6 abnormal olfactory bulb layer morphology 0.0538854360783208 0.192309931484681 1.12605119674707 0.833333333333333 5.6 5 6 increased erythrocyte clearance 0.0538854360783208 0.192309931484681 1.12605119674707 0.833333333333333 5.6 5 6 kidney microaneurysm 0.0538854360783208 0.192309931484681 1.12605119674707 0.833333333333333 5.6 5 6 cerebral arteriovenous malformation 0.0538854360783208 0.192309931484681 1.12605119674707 0.833333333333333 5.6 5 6 abnormal intestinal enteroendocrine cell morphology 0.0538854360783208 0.192309931484681 1.12605119674707 0.833333333333333 5.6 5 6 increased total lung capacity 0.0538854360783208 0.192309931484681 1.12605119674707 0.833333333333333 5.6 5 6 ectopic ureteric bud 0.0538854360783208 0.192309931484681 1.12605119674707 0.833333333333333 5.6 5 6 abnormal ureteric bud tip morphology 0.0538854360783208 0.192309931484681 1.12605119674707 0.833333333333333 5.6 5 6 abnormal endocrine pancreas development 0.0538854360783208 0.192309931484681 1.12605119674707 0.833333333333333 5.6 5 6 increased total retina thickness 0.0538854360783208 0.192309931484681 1.12605119674707 0.833333333333333 5.6 5 6 absent midbrain 0.0538854360783208 0.192309931484681 1.12605119674707 0.833333333333333 5.6 5 6 delayed limb development 0.0538854360783208 0.192309931484681 1.12605119674707 0.833333333333333 5.6 5 6 thymus cortex atrophy 0.0538854360783208 0.192309931484681 1.12605119674707 0.833333333333333 5.6 5 6 increased CD11b-high dendritic cell number 0.0538854360783208 0.192309931484681 1.12605119674707 0.833333333333333 5.6 5 6 absent thymus corticomedullary boundary 0.0538854360783208 0.192309931484681 1.12605119674707 0.833333333333333 5.6 5 6 additional anastomosis between intracranial vertebral arteries 0.0538854360783208 0.192309931484681 1.12605119674707 0.833333333333333 5.6 5 6 decreased retinal apoptosis 0.0538854360783208 0.192309931484681 1.12605119674707 0.833333333333333 5.6 5 6 abnormal cell nucleus morphology 1.41523448913308e-08 4.63209972594544e-07 1.12125948952687 0.829787234042553 5.6 5 6 abnormal embryonic epiblast morphology 1.1519327947611e-06 2.56989491207913e-05 1.11961661847994 0.828571428571429 5.6 5 6 abnormal hippocampus pyramidal cell morphology 1.1519327947611e-06 2.56989491207913e-05 1.11961661847994 0.828571428571429 5.6 5 6 increased mortality induced by gamma-irradiation 1.05682356914683e-05 0.000184480605491421 1.11828532642467 0.827586206896552 5.6 5 6 embryonic lethality between implantation and placentation, complete penetrance 2.77637779021945e-08 8.43173649524817e-07 1.11625944721013 0.826086956521739 5.6 5 6 abnormal cell morphology 1.94152946017414e-18 2.53702119562555e-16 1.11419802625499 0.824561403508772 5.6 5 6 decreased brain weight 6.85983393126577e-10 3.02014812460595e-08 1.11419802625499 0.824561403508772 5.6 5 6 abnormal touch/ nociception 0.000947992994152067 0.00866960504762231 1.11280353560887 0.823529411764706 5.6 5 6 abnormal involuntary movement 0.000947992994152067 0.00866960504762231 1.11280353560887 0.823529411764706 5.6 5 6 abnormal embryonic-extraembryonic boundary morphology 0.000947992994152067 0.00866960504762231 1.11280353560887 0.823529411764706 5.6 5 6 increased brain size 0.000947992994152067 0.00866960504762231 1.11280353560887 0.823529411764706 5.6 5 6 coloboma 0.000947992994152067 0.00866960504762231 1.11280353560887 0.823529411764706 5.6 5 6 enhanced behavioral response to cocaine 0.000947992994152067 0.00866960504762231 1.11280353560887 0.823529411764706 5.6 5 6 abnormal cell cytoskeleton morphology 0.000947992994152067 0.00866960504762231 1.11280353560887 0.823529411764706 5.6 5 6 abnormal dendritic spine morphology 6.08409000452248e-09 2.29305664943177e-07 1.11280353560887 0.823529411764706 5.6 5 6 abnormal ectoderm development 5.42339280966058e-08 1.52437170780008e-06 1.11103718079044 0.822222222222222 5.6 5 6 myoclonus 2.07171634050438e-05 0.000335726019348837 1.10996475107925 0.821428571428571 5.6 5 6 abnormal mitotic spindle morphology 2.07171634050438e-05 0.000335726019348837 1.10996475107925 0.821428571428571 5.6 5 6 increased embryonic tissue cell apoptosis 8.48334206965582e-13 5.70332794547807e-11 1.10872733218173 0.82051282051282 5.6 5 6 limb grasping 9.5754852127153e-28 2.64655771851437e-25 1.10625249438668 0.818681318681319 5.6 5 6 abnormal cerebral cortex pyramidal cell morphology 0.000193414189442497 0.00229103712494386 1.10557753862439 0.818181818181818 5.6 5 6 embryonic lethality before implantation, incomplete penetrance 0.000193414189442497 0.00229103712494386 1.10557753862439 0.818181818181818 5.6 5 6 abnormal eye distance/ position 0.00956729717732341 0.0561288955863018 1.10557753862439 0.818181818181818 5.6 5 6 failure of somite differentiation 0.00956729717732341 0.0561288955863018 1.10557753862439 0.818181818181818 5.6 5 6 abnormal vestibular ganglion morphology 0.00956729717732341 0.0561288955863018 1.10557753862439 0.818181818181818 5.6 5 6 impaired luteinization 0.00956729717732341 0.0561288955863018 1.10557753862439 0.818181818181818 5.6 5 6 abnormal ureter development 0.00956729717732341 0.0561288955863018 1.10557753862439 0.818181818181818 5.6 5 6 thin hypoglossal nerve 0.00956729717732341 0.0561288955863018 1.10557753862439 0.818181818181818 5.6 5 6 increased neuron apoptosis 7.04838763143197e-13 4.87024006477417e-11 1.10102783681935 0.814814814814815 5.6 5 6 abnormal atrioventricular cushion morphology 4.03324656524337e-05 0.000584997133005415 1.10102783681935 0.814814814814815 5.6 5 6 abnormal trigeminal nerve morphology 4.03324656524337e-05 0.000584997133005415 1.10102783681935 0.814814814814815 5.6 5 6 abnormal trigeminal ganglion morphology 4.03324656524337e-05 0.000584997133005415 1.10102783681935 0.814814814814815 5.6 5 6 increased brain weight 4.03324656524337e-05 0.000584997133005415 1.10102783681935 0.814814814814815 5.6 5 6 scoliosis 8.53416971512471e-06 0.000152177399042098 1.09789991682839 0.8125 5.6 5 6 neonatal lethality 8.53416971512471e-06 0.000152177399042098 1.09789991682839 0.8125 5.6 5 6 increased fibroblast apoptosis 8.53416971512471e-06 0.000152177399042098 1.09789991682839 0.8125 5.6 5 6 disorganized retinal layers 0.00185641793248292 0.0150418228242712 1.09789991682839 0.8125 5.6 5 6 intraventricular hemorrhage 0.00185641793248292 0.0150418228242712 1.09789991682839 0.8125 5.6 5 6 impaired muscle relaxation 0.00185641793248292 0.0150418228242712 1.09789991682839 0.8125 5.6 5 6 blepharitis 0.00185641793248292 0.0150418228242712 1.09789991682839 0.8125 5.6 5 6 impaired somite development 0.00185641793248292 0.0150418228242712 1.09789991682839 0.8125 5.6 5 6 decreased liver cholesterol level 0.00185641793248292 0.0150418228242712 1.09789991682839 0.8125 5.6 5 6 decreased fibroblast apoptosis 0.00185641793248292 0.0150418228242712 1.09789991682839 0.8125 5.6 5 6 abnormal lung development 3.00811807908065e-13 2.16889673093134e-11 1.09690634224302 0.811764705882353 5.6 5 6 decreased cell proliferation 4.75382790536889e-27 1.12620446805763e-24 1.09561738061877 0.810810810810811 5.6 5 6 spina bifida 3.9318787407467e-07 9.54199840742186e-06 1.09387830541144 0.80952380952381 5.6 5 6 abnormal scapula morphology 0.000375711659444553 0.00404581278297976 1.09387830541144 0.80952380952381 5.6 5 6 left pulmonary isomerism 0.000375711659444553 0.00404581278297976 1.09387830541144 0.80952380952381 5.6 5 6 embryonic lethality, complete penetrance 3.78553128001898e-45 2.09255756867716e-42 1.09286975082411 0.808777429467085 5.6 5 6 small liver 4.98981034624814e-12 3.10303830907306e-10 1.09140346761639 0.807692307692308 5.6 5 6 abnormal ureter morphology 7.79371223552065e-05 0.00103094952009019 1.09140346761639 0.807692307692308 5.6 5 6 abnormal embryo size 1.32285234422934e-16 1.46248675834244e-14 1.08818398836088 0.805309734513274 5.6 5 6 reduced long term potentiation 2.51798700225523e-16 2.7232576817869e-14 1.08583508257753 0.803571428571429 5.6 5 6 ataxia 4.62699265241102e-28 1.35407579092617e-25 1.08368491409718 0.801980198019802 5.6 5 6 abnormal posture 7.6015500236147e-12 4.55635076716664e-10 1.08100914887718 0.8 5.6 5 6 spleen atrophy 0.000722867234603994 0.00688939557884075 1.08100914887718 0.8 5.6 5 6 abnormal sperm mitochondrial sheath morphology 0.000722867234603994 0.00688939557884075 1.08100914887718 0.8 5.6 5 6 increased cranium width 0.0187066388458662 0.0897449645691265 1.08100914887718 0.8 5.6 5 6 small petrosal ganglion 0.0187066388458662 0.0897449645691265 1.08100914887718 0.8 5.6 5 6 abnormal optic nerve innervation 0.0187066388458662 0.0897449645691265 1.08100914887718 0.8 5.6 5 6 abnormal immune cell physiology 0.0187066388458662 0.0897449645691265 1.08100914887718 0.8 5.6 5 6 rhinitis 0.0187066388458662 0.0897449645691265 1.08100914887718 0.8 5.6 5 6 decreased incidence of induced tumors 0.0187066388458662 0.0897449645691265 1.08100914887718 0.8 5.6 5 6 abnormal PNS synaptic transmission 0.0187066388458662 0.0897449645691265 1.08100914887718 0.8 5.6 5 6 acrania 0.0187066388458662 0.0897449645691265 1.08100914887718 0.8 5.6 5 6 peritoneal inflammation 0.0187066388458662 0.0897449645691265 1.08100914887718 0.8 5.6 5 6 abnormal hypaxial muscle morphology 0.0187066388458662 0.0897449645691265 1.08100914887718 0.8 5.6 5 6 bifid ureter 0.0187066388458662 0.0897449645691265 1.08100914887718 0.8 5.6 5 6 abnormal pillar cell morphology 0.0187066388458662 0.0897449645691265 1.08100914887718 0.8 5.6 5 6 abnormal ear physiology 0.0187066388458662 0.0897449645691265 1.08100914887718 0.8 5.6 5 6 increased heart rate variability 0.0187066388458662 0.0897449645691265 1.08100914887718 0.8 5.6 5 6 abnormal gas homeostasis 0.0187066388458662 0.0897449645691265 1.08100914887718 0.8 5.6 5 6 abnormal corneal endothelium morphology 0.0187066388458662 0.0897449645691265 1.08100914887718 0.8 5.6 5 6 osteosclerosis 0.0187066388458662 0.0897449645691265 1.08100914887718 0.8 5.6 5 6 increased serotonin level 0.0187066388458662 0.0897449645691265 1.08100914887718 0.8 5.6 5 6 umbilical hernia 0.0187066388458662 0.0897449645691265 1.08100914887718 0.8 5.6 5 6 thin ventricle myocardium compact layer 0.0187066388458662 0.0897449645691265 1.08100914887718 0.8 5.6 5 6 fusion of atlas and odontoid process 0.0187066388458662 0.0897449645691265 1.08100914887718 0.8 5.6 5 6 abnormal erythropoiesis 4.07709065649585e-15 4.05670520321337e-13 1.08100914887718 0.8 5.6 5 6 enhanced paired-pulse facilitation 3.14152819997123e-05 0.000482379715890644 1.08100914887718 0.8 5.6 5 6 increased cellular sensitivity to ionizing radiation 0.000149396289567659 0.00181103070179243 1.08100914887718 0.8 5.6 5 6 abnormal vertebrae development 0.000149396289567659 0.00181103070179243 1.08100914887718 0.8 5.6 5 6 abnormal pup retrieval 0.00359249827080489 0.0251373824152663 1.08100914887718 0.8 5.6 5 6 audiogenic seizures 0.00359249827080489 0.0251373824152663 1.08100914887718 0.8 5.6 5 6 abnormal trophectoderm morphology 0.00359249827080489 0.0251373824152663 1.08100914887718 0.8 5.6 5 6 abnormal cerebral aqueduct morphology 0.00359249827080489 0.0251373824152663 1.08100914887718 0.8 5.6 5 6 abnormal secondary palate development 0.00359249827080489 0.0251373824152663 1.08100914887718 0.8 5.6 5 6 abnormal neuron morphology 3.47013150197169e-14 2.83757341113704e-12 1.07827932779416 0.797979797979798 5.6 5 6 abnormal maxilla morphology 2.78668985205005e-08 8.43173649524817e-07 1.07600447689164 0.796296296296296 5.6 5 6 omphalocele 5.87867345279829e-07 1.40365511650039e-05 1.07486705144038 0.795454545454545 5.6 5 6 increased hepatocyte apoptosis 2.72059940771623e-06 5.61617512588723e-05 1.07407960305105 0.794871794871795 5.6 5 6 abnormal embryonic neuroepithelium morphology 1.14983504583737e-08 3.90619129181027e-07 1.07169010449031 0.793103448275862 5.6 5 6 blood in lymph vessels 5.96213863070832e-05 0.000821410984750499 1.07169010449031 0.793103448275862 5.6 5 6 abnormal excitatory postsynaptic potential 1.12757864694322e-11 6.59965149240299e-10 1.07112187007648 0.792682926829268 5.6 5 6 embryonic lethality between implantation and somite formation, complete penetrance 6.35195492631688e-32 2.43084428910973e-29 1.0699784432764 0.791836734693877 5.6 5 6 increased susceptibility to pharmacologically induced seizures 2.31094833912076e-13 1.74196484653421e-11 1.06974863690971 0.791666666666667 5.6 5 6 abnormal nursing 0.000283889692820346 0.00317382297029488 1.06974863690971 0.791666666666667 5.6 5 6 abnormal impulse conducting system conduction 0.000283889692820346 0.00317382297029488 1.06974863690971 0.791666666666667 5.6 5 6 decreased neuron apoptosis 5.12409549174344e-06 9.9192120900481e-05 1.06678534428669 0.789473684210526 5.6 5 6 kyphoscoliosis 0.0013761642647965 0.0117032772946369 1.06678534428669 0.789473684210526 5.6 5 6 unresponsive to tactile stimuli 0.0013761642647965 0.0117032772946369 1.06678534428669 0.789473684210526 5.6 5 6 abnormal long term depression 0.0013761642647965 0.0117032772946369 1.06678534428669 0.789473684210526 5.6 5 6 abnormal cochlear inner hair cell morphology 0.0013761642647965 0.0117032772946369 1.06678534428669 0.789473684210526 5.6 5 6 abnormal behavioral response to xenobiotic 0.0013761642647965 0.0117032772946369 1.06678534428669 0.789473684210526 5.6 5 6 decreased circulating magnesium level 0.0013761642647965 0.0117032772946369 1.06678534428669 0.789473684210526 5.6 5 6 increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 0.0013761642647965 0.0117032772946369 1.06678534428669 0.789473684210526 5.6 5 6 embryonic lethality between implantation and somite formation, incomplete penetrance 0.0013761642647965 0.0117032772946369 1.06678534428669 0.789473684210526 5.6 5 6 seizures 1.98761866745004e-15 2.01804140215591e-13 1.06678534428669 0.789473684210526 5.6 5 6 dextrocardia 2.38749003966598e-05 0.000380697530363406 1.06463022237904 0.787878787878788 5.6 5 6 abnormal axon morphology 1.66320726936329e-14 1.42663037329006e-12 1.06349279692778 0.787037037037037 5.6 5 6 enhanced long term potentiation 4.03083789403256e-08 1.18659281200071e-06 1.0617054140758 0.785714285714286 5.6 5 6 premature aging 0.000112255240559529 0.00142831156466409 1.0617054140758 0.785714285714286 5.6 5 6 hypoxia 0.000112255240559529 0.00142831156466409 1.0617054140758 0.785714285714286 5.6 5 6 subcutaneous edema 0.000112255240559529 0.00142831156466409 1.0617054140758 0.785714285714286 5.6 5 6 abnormal adrenal gland secretion 0.00685912784379011 0.0417676389508639 1.0617054140758 0.785714285714286 5.6 5 6 failure of zygotic cell division 0.00685912784379011 0.0417676389508639 1.0617054140758 0.785714285714286 5.6 5 6 abnormal voluntary movement 0.00685912784379011 0.0417676389508639 1.0617054140758 0.785714285714286 5.6 5 6 decreased CNS synapse formation 0.00685912784379011 0.0417676389508639 1.0617054140758 0.785714285714286 5.6 5 6 pulmonary alveolar hemorrhage 0.00685912784379011 0.0417676389508639 1.0617054140758 0.785714285714286 5.6 5 6 abnormal renal tubule epithelial cell primary cilium morphology 0.00685912784379011 0.0417676389508639 1.0617054140758 0.785714285714286 5.6 5 6 abnormal response to novel object 1.83801125500149e-07 4.90676681395525e-06 1.05981289105606 0.784313725490196 5.6 5 6 kidney cysts 3.31396544145931e-10 1.55537528974152e-08 1.05909680126481 0.783783783783784 5.6 5 6 abnormal calcium ion homeostasis 9.58958477846359e-06 0.000167986564341044 1.05909680126481 0.783783783783784 5.6 5 6 absent mesoderm 1.65032091849699e-08 5.29699778678872e-07 1.05848812494224 0.783333333333333 5.6 5 6 microcephaly 1.49557591576662e-09 6.1491654387925e-08 1.05750894998855 0.782608695652174 5.6 5 6 abnormal innervation pattern to muscle 0.000534373156373016 0.00540346840031658 1.05750894998855 0.782608695652174 5.6 5 6 dilated heart 0.000534373156373016 0.00540346840031658 1.05750894998855 0.782608695652174 5.6 5 6 decreased effector memory CD8-positive, alpha-beta T cell number 0.000534373156373016 0.00540346840031658 1.05750894998855 0.782608695652174 5.6 5 6 increased sacral vertebrae number 6.75880878880596e-09 2.49074620180071e-07 1.05567299695037 0.78125 5.6 5 6 abnormal long term potentiation 4.46327633594064e-05 0.000638068958945537 1.05567299695037 0.78125 5.6 5 6 Leydig cell hyperplasia 3.8620347299046e-06 7.71631436999011e-05 1.0546430720753 0.780487804878049 5.6 5 6 lethality at weaning, incomplete penetrance 3.8620347299046e-06 7.71631436999011e-05 1.0546430720753 0.780487804878049 5.6 5 6 abnormal axon extension 3.41342728520252e-07 8.53356821300629e-06 1.05398392015525 0.78 5.6 5 6 abnormal embryo development 3.50639495261749e-17 4.05681741610977e-15 1.05318906048696 0.779411764705882 5.6 5 6 abnormal inhibitory postsynaptic currents 2.76893573768388e-09 1.10203642359818e-07 1.05318906048696 0.779411764705882 5.6 5 6 abnormal CNS synaptic transmission 8.77240684619807e-13 5.81902987464472e-11 1.05098111696393 0.777777777777778 5.6 5 6 underdeveloped hair follicles 0.00258935077619314 0.0192556354432898 1.05098111696393 0.777777777777778 5.6 5 6 abnormal thyroid cartilage morphology 0.00258935077619314 0.0192556354432898 1.05098111696393 0.777777777777778 5.6 5 6 abnormal bile duct morphology 0.00258935077619314 0.0192556354432898 1.05098111696393 0.777777777777778 5.6 5 6 absent inner cell mass 0.00258935077619314 0.0192556354432898 1.05098111696393 0.777777777777778 5.6 5 6 abnormal eye anterior chamber morphology 0.00258935077619314 0.0192556354432898 1.05098111696393 0.777777777777778 5.6 5 6 darkened coat color 0.00258935077619314 0.0192556354432898 1.05098111696393 0.777777777777778 5.6 5 6 increased effector memory CD4-positive, alpha-beta T cell number 0.00258935077619314 0.0192556354432898 1.05098111696393 0.777777777777778 5.6 5 6 small nodose ganglion 0.035901098777741 0.143169370490414 1.05098111696393 0.777777777777778 5.6 5 6 dilated uterus 0.035901098777741 0.143169370490414 1.05098111696393 0.777777777777778 5.6 5 6 wavy vibrissae 0.035901098777741 0.143169370490414 1.05098111696393 0.777777777777778 5.6 5 6 abnormal ion homeostasis 0.035901098777741 0.143169370490414 1.05098111696393 0.777777777777778 5.6 5 6 increased pheochromocytoma incidence 0.035901098777741 0.143169370490414 1.05098111696393 0.777777777777778 5.6 5 6 abnormal germ cell morphology 0.035901098777741 0.143169370490414 1.05098111696393 0.777777777777778 5.6 5 6 abnormal posterior semicircular canal morphology 0.035901098777741 0.143169370490414 1.05098111696393 0.777777777777778 5.6 5 6 biliary cyst 0.035901098777741 0.143169370490414 1.05098111696393 0.777777777777778 5.6 5 6 abnormal artery development 0.035901098777741 0.143169370490414 1.05098111696393 0.777777777777778 5.6 5 6 premature neuronal precursor differentiation 0.035901098777741 0.143169370490414 1.05098111696393 0.777777777777778 5.6 5 6 positive geotaxis 0.035901098777741 0.143169370490414 1.05098111696393 0.777777777777778 5.6 5 6 abnormal optic chiasm morphology 0.035901098777741 0.143169370490414 1.05098111696393 0.777777777777778 5.6 5 6 multiflagellated sperm 0.035901098777741 0.143169370490414 1.05098111696393 0.777777777777778 5.6 5 6 retropulsion 0.035901098777741 0.143169370490414 1.05098111696393 0.777777777777778 5.6 5 6 prolonged RR interval 0.035901098777741 0.143169370490414 1.05098111696393 0.777777777777778 5.6 5 6 abnormal lung lobe morphology 0.035901098777741 0.143169370490414 1.05098111696393 0.777777777777778 5.6 5 6 increased myeloid cell number 0.035901098777741 0.143169370490414 1.05098111696393 0.777777777777778 5.6 5 6 trigeminal neuroma 0.035901098777741 0.143169370490414 1.05098111696393 0.777777777777778 5.6 5 6 abnormal ductus venosus valve topology 0.035901098777741 0.143169370490414 1.05098111696393 0.777777777777778 5.6 5 6 abnormal infrahyoid muscle connection 0.035901098777741 0.143169370490414 1.05098111696393 0.777777777777778 5.6 5 6 symmetric azygos veins 0.035901098777741 0.143169370490414 1.05098111696393 0.777777777777778 5.6 5 6 increased cardiac muscle glycogen level 0.035901098777741 0.143169370490414 1.05098111696393 0.777777777777778 5.6 5 6 gliosis 1.24947219654353e-08 4.1440827852027e-07 1.05098111696393 0.777777777777778 5.6 5 6 decreased susceptibility to pharmacologically induced seizures 0.000209553420814911 0.00244724945669996 1.05098111696393 0.777777777777778 5.6 5 6 abnormal skin appearance 0.000209553420814911 0.00244724945669996 1.05098111696393 0.777777777777778 5.6 5 6 preweaning lethality, complete penetrance 7.37187288418482e-86 3.66750675988195e-82 1.04814062745862 0.775675675675676 5.6 5 6 abnormal capillary morphology 8.27908645993726e-05 0.00107823180990021 1.04613788601018 0.774193548387097 5.6 5 6 inner cell mass degeneration 8.27908645993726e-05 0.00107823180990021 1.04613788601018 0.774193548387097 5.6 5 6 abnormal spatial learning 1.32946818516278e-19 2.13358200683382e-17 1.04453338005004 0.773006134969325 5.6 5 6 abnormal motor capabilities/coordination/movement 3.99545137002479e-16 4.14111886789028e-14 1.04415656425637 0.772727272727273 5.6 5 6 abnormal channel response 0.000995523057451549 0.00905434590643776 1.04415656425637 0.772727272727273 5.6 5 6 abnormal occipital bone morphology 0.000995523057451549 0.00905434590643776 1.04415656425637 0.772727272727273 5.6 5 6 increased adenoma incidence 0.000995523057451549 0.00905434590643776 1.04415656425637 0.772727272727273 5.6 5 6 preweaning lethality, incomplete penetrance 5.82634250229747e-47 3.62325674361624e-44 1.04400639072491 0.772616136919315 5.6 5 6 abnormal locomotor behavior 1.31790090970455e-11 7.62390351834897e-10 1.04282132568315 0.771739130434783 5.6 5 6 domed cranium 3.8272362564921e-09 1.48753909187877e-07 1.04240167927443 0.771428571428571 5.6 5 6 embryonic lethality between somite formation and embryo turning, complete penetrance 3.8272362564921e-09 1.48753909187877e-07 1.04240167927443 0.771428571428571 5.6 5 6 abnormal liver development 3.29005213437629e-05 0.000497507883541703 1.04240167927443 0.771428571428571 5.6 5 6 abnormal midbrain development 3.29005213437629e-05 0.000497507883541703 1.04240167927443 0.771428571428571 5.6 5 6 abnormal neural tube closure 1.43231368847802e-10 7.27118428589608e-09 1.04193652903825 0.771084337349398 5.6 5 6 decreased embryo size 8.04125640370767e-54 8.00105012168913e-51 1.04030169138808 0.769874476987448 5.6 5 6 decreased startle reflex 3.47923574028863e-14 2.83757341113704e-12 1.03943187392037 0.769230769230769 5.6 5 6 increased thymocyte apoptosis 0.000387593513609169 0.00416474671750673 1.03943187392037 0.769230769230769 5.6 5 6 short premaxilla 0.0128956570682675 0.0693577231509524 1.03943187392037 0.769230769230769 5.6 5 6 abnormal tail bud morphology 0.0128956570682675 0.0693577231509524 1.03943187392037 0.769230769230769 5.6 5 6 abnormal bile duct development 0.0128956570682675 0.0693577231509524 1.03943187392037 0.769230769230769 5.6 5 6 muscle fatigue 0.0128956570682675 0.0693577231509524 1.03943187392037 0.769230769230769 5.6 5 6 decreased endocochlear potential 0.0128956570682675 0.0693577231509524 1.03943187392037 0.769230769230769 5.6 5 6 orthokeratosis 0.0128956570682675 0.0693577231509524 1.03943187392037 0.769230769230769 5.6 5 6 increased prostaglandin level 0.0128956570682675 0.0693577231509524 1.03943187392037 0.769230769230769 5.6 5 6 embryonic growth arrest 2.80246351984257e-26 5.80927333800699e-24 1.03852407315712 0.768558951965066 5.6 5 6 abnormal axon guidance 5.26464940214221e-06 0.000101125987550801 1.03701459049265 0.767441860465116 5.6 5 6 abnormal double-strand DNA break repair 5.26464940214221e-06 0.000101125987550801 1.03701459049265 0.767441860465116 5.6 5 6 abnormal eating behavior 7.68912508082236e-08 2.13706130039616e-06 1.0359671010073 0.766666666666667 5.6 5 6 abnormal behavior 3.6446254292687e-31 1.29514367932941e-28 1.03531901398759 0.766187050359712 5.6 5 6 increased cellular sensitivity to gamma-irradiation 2.11673546436165e-06 4.50032433128171e-05 1.03500875956326 0.765957446808511 5.6 5 6 lethality throughout fetal growth and development, incomplete penetrance 1.74075565559041e-20 2.98629634019389e-18 1.03420568014088 0.76536312849162 5.6 5 6 distended abdomen 8.53352938335591e-07 1.9838462001026e-05 1.03331756877966 0.764705882352941 5.6 5 6 abnormal gastrulation 8.53352938335591e-07 1.9838462001026e-05 1.03331756877966 0.764705882352941 5.6 5 6 enlarged liver sinusoidal spaces 6.0264323504308e-05 0.000821410984750499 1.03331756877966 0.764705882352941 5.6 5 6 overexpanded pulmonary alveoli 6.0264323504308e-05 0.000821410984750499 1.03331756877966 0.764705882352941 5.6 5 6 abnormal brown adipose tissue morphology 6.0264323504308e-05 0.000821410984750499 1.03331756877966 0.764705882352941 5.6 5 6 abnormal direction of heart looping 6.0264323504308e-05 0.000821410984750499 1.03331756877966 0.764705882352941 5.6 5 6 abnormal adipose tissue morphology 0.00480879898205819 0.0318718842422328 1.03331756877966 0.764705882352941 5.6 5 6 abnormal interatrial septum morphology 0.00480879898205819 0.0318718842422328 1.03331756877966 0.764705882352941 5.6 5 6 distended urinary bladder 0.00480879898205819 0.0318718842422328 1.03331756877966 0.764705882352941 5.6 5 6 hyperlipidemia 0.00480879898205819 0.0318718842422328 1.03331756877966 0.764705882352941 5.6 5 6 abnormal glutamate-mediated receptor currents 0.00480879898205819 0.0318718842422328 1.03331756877966 0.764705882352941 5.6 5 6 abnormal ectoplacental cone morphology 0.00480879898205819 0.0318718842422328 1.03331756877966 0.764705882352941 5.6 5 6 abnormal tarsal bone morphology 0.00480879898205819 0.0318718842422328 1.03331756877966 0.764705882352941 5.6 5 6 abnormal ductus venosus valve morphology 0.00480879898205819 0.0318718842422328 1.03331756877966 0.764705882352941 5.6 5 6 increased startle reflex 7.93785760172311e-11 4.20115335835878e-09 1.03242446802877 0.764044943820225 5.6 5 6 abnormal brain morphology 1.98882063576676e-18 2.53702119562555e-16 1.03233016546501 0.763975155279503 5.6 5 6 decreased circulating total protein level 3.44812755482908e-07 8.57721729263733e-06 1.03187236938277 0.763636363636364 5.6 5 6 decreased total retina thickness 2.39783835912288e-05 0.000381126065068253 1.03122583281047 0.763157894736842 5.6 5 6 hyperactivity 2.5421007613395e-40 1.2646951287664e-37 1.03074659411133 0.762803234501348 5.6 5 6 decreased grip strength 2.425264191087e-24 4.46877383357696e-22 1.03041397181786 0.762557077625571 5.6 5 6 abnormal eye pigmentation 0.00183376507511421 0.0150418228242712 1.02953252274017 0.761904761904762 5.6 5 6 decreased cochlear outer hair cell number 0.00183376507511421 0.0150418228242712 1.02953252274017 0.761904761904762 5.6 5 6 increased muscle cell glucose uptake 0.00183376507511421 0.0150418228242712 1.02953252274017 0.761904761904762 5.6 5 6 abnormal cell death 3.84400900993617e-06 7.71631436999011e-05 1.02813370137776 0.760869565217391 5.6 5 6 pallor 1.8525999282132e-19 2.7929347402608e-17 1.02695869143332 0.76 5.6 5 6 increased B cell derived lymphoma incidence 1.54661262756713e-06 3.38960256482223e-05 1.02695869143332 0.76 5.6 5 6 spontaneous skin ulceration 0.000709785469787185 0.00681695504284024 1.02695869143332 0.76 5.6 5 6 abnormal primitive streak morphology 0.000709785469787185 0.00681695504284024 1.02695869143332 0.76 5.6 5 6 abnormal apoptosis 6.238725292552e-07 1.47798373002125e-05 1.02595775703622 0.759259259259259 5.6 5 6 pericardial effusion 1.0215372446898e-07 2.7771299411649e-06 1.0243433467183 0.758064516129032 5.6 5 6 decreased width of hypertrophic chondrocyte zone 4.34502254290309e-05 0.000626564844954865 1.02257622191085 0.756756756756757 5.6 5 6 abnormal myocardial trabeculae morphology 6.9372061470194e-06 0.000128778360378439 1.02095308505067 0.755555555555556 5.6 5 6 abnormal mesoderm development 1.12264457185805e-06 2.53870761136082e-05 1.01981995177093 0.754716981132076 5.6 5 6 atrioventricular septal defect 1.12264457185805e-06 2.53870761136082e-05 1.01981995177093 0.754716981132076 5.6 5 6 seminiferous tubule degeneration 1.22709426902295e-08 4.1003752690405e-07 1.01807368473022 0.753424657534247 5.6 5 6 embryonic lethality before implantation, complete penetrance 1.09240089588864e-13 8.49171008913432e-12 1.01614859994455 0.752 5.6 5 6 prenatal lethality, complete penetrance 1.25502775491328e-28 3.90235192543348e-26 1.01587640339627 0.751798561151079 5.6 5 6 abnormal forebrain development 2.18903313678124e-08 6.80652490967916e-07 1.01344607707236 0.75 5.6 5 6 abnormal pharyngeal arch morphology 7.81242148892466e-05 0.00103094952009019 1.01344607707236 0.75 5.6 5 6 abnormal lumbar vertebrae morphology 0.000197265168319271 0.00231880018620282 1.01344607707236 0.75 5.6 5 6 pancreatic islet hyperplasia 0.000197265168319271 0.00231880018620282 1.01344607707236 0.75 5.6 5 6 abnormal auditory brainstem response waveform shape 0.000197265168319271 0.00231880018620282 1.01344607707236 0.75 5.6 5 6 vasculature congestion 0.00880073928577081 0.0524355424511494 1.01344607707236 0.75 5.6 5 6 poor circulation 0.00880073928577081 0.0524355424511494 1.01344607707236 0.75 5.6 5 6 abnormal epicardium morphology 0.00880073928577081 0.0524355424511494 1.01344607707236 0.75 5.6 5 6 paternal imprinting 0.00880073928577081 0.0524355424511494 1.01344607707236 0.75 5.6 5 6 decreased circulating triiodothyronine level 0.00880073928577081 0.0524355424511494 1.01344607707236 0.75 5.6 5 6 impaired behavioral response to addictive substance 0.00880073928577081 0.0524355424511494 1.01344607707236 0.75 5.6 5 6 embryonic lethality between somite formation and embryo turning, incomplete penetrance 0.00880073928577081 0.0524355424511494 1.01344607707236 0.75 5.6 5 6 abnormal ear pigmentation 0.0673503565484828 0.226091783959988 1.01344607707236 0.75 5.6 5 6 absent mammary gland 0.0673503565484828 0.226091783959988 1.01344607707236 0.75 5.6 5 6 abnormal vagus ganglion morphology 0.0673503565484828 0.226091783959988 1.01344607707236 0.75 5.6 5 6 dermal cysts 0.0673503565484828 0.226091783959988 1.01344607707236 0.75 5.6 5 6 dry eyes 0.0673503565484828 0.226091783959988 1.01344607707236 0.75 5.6 5 6 absent eyelids 0.0673503565484828 0.226091783959988 1.01344607707236 0.75 5.6 5 6 abnormal urination 0.0673503565484828 0.226091783959988 1.01344607707236 0.75 5.6 5 6 abnormal secondary sex determination 0.0673503565484828 0.226091783959988 1.01344607707236 0.75 5.6 5 6 abnormal thyroid physiology 0.0673503565484828 0.226091783959988 1.01344607707236 0.75 5.6 5 6 altered response to CNS ischemic injury 0.0673503565484828 0.226091783959988 1.01344607707236 0.75 5.6 5 6 absent tympanic ring 0.0673503565484828 0.226091783959988 1.01344607707236 0.75 5.6 5 6 decreased susceptibility to age related obesity 0.0673503565484828 0.226091783959988 1.01344607707236 0.75 5.6 5 6 abnormal eyelid aperture 0.0673503565484828 0.226091783959988 1.01344607707236 0.75 5.6 5 6 elevated level of mitotic sister chromatid exchange 0.0673503565484828 0.226091783959988 1.01344607707236 0.75 5.6 5 6 binucleate 0.0673503565484828 0.226091783959988 1.01344607707236 0.75 5.6 5 6 tau protein deposits 0.0673503565484828 0.226091783959988 1.01344607707236 0.75 5.6 5 6 abnormal extraembryonic tissue physiology 0.0673503565484828 0.226091783959988 1.01344607707236 0.75 5.6 5 6 abnormal hair follicle melanocyte morphology 0.0673503565484828 0.226091783959988 1.01344607707236 0.75 5.6 5 6 absent cochlear microphonics 0.0673503565484828 0.226091783959988 1.01344607707236 0.75 5.6 5 6 abnormal somite size 0.0673503565484828 0.226091783959988 1.01344607707236 0.75 5.6 5 6 ocular hypertension 0.0673503565484828 0.226091783959988 1.01344607707236 0.75 5.6 5 6 increased pulmonary ventilation 0.0673503565484828 0.226091783959988 1.01344607707236 0.75 5.6 5 6 hypergranulosis 0.0673503565484828 0.226091783959988 1.01344607707236 0.75 5.6 5 6 abnormal epidermal lamellar body morphology 0.0673503565484828 0.226091783959988 1.01344607707236 0.75 5.6 5 6 abnormal sphingomyelin level 0.0673503565484828 0.226091783959988 1.01344607707236 0.75 5.6 5 6 increased caudal vertebrae number 0.0673503565484828 0.226091783959988 1.01344607707236 0.75 5.6 5 6 abnormal brain ependyma morphology 0.0673503565484828 0.226091783959988 1.01344607707236 0.75 5.6 5 6 decreased quadriceps weight 0.0673503565484828 0.226091783959988 1.01344607707236 0.75 5.6 5 6 ostium secundum atrial septal defect 0.0673503565484828 0.226091783959988 1.01344607707236 0.75 5.6 5 6 abnormal hepatic vein morphology 0.0673503565484828 0.226091783959988 1.01344607707236 0.75 5.6 5 6 sinoatrial block 0.0673503565484828 0.226091783959988 1.01344607707236 0.75 5.6 5 6 abnormal stomach position or orientation 0.0673503565484828 0.226091783959988 1.01344607707236 0.75 5.6 5 6 abnormal maxillary prominence morphology 0.0673503565484828 0.226091783959988 1.01344607707236 0.75 5.6 5 6 abnormal foramen magnum morphology 0.0673503565484828 0.226091783959988 1.01344607707236 0.75 5.6 5 6 abnormal branching involved in ureteric bud morphogenesis 0.0673503565484828 0.226091783959988 1.01344607707236 0.75 5.6 5 6 increased aorta wall thickness 0.0673503565484828 0.226091783959988 1.01344607707236 0.75 5.6 5 6 impaired neuron differentiation 0.0673503565484828 0.226091783959988 1.01344607707236 0.75 5.6 5 6 increased mammary gland apoptosis 0.0673503565484828 0.226091783959988 1.01344607707236 0.75 5.6 5 6 decreased basal metabolism 0.0673503565484828 0.226091783959988 1.01344607707236 0.75 5.6 5 6 decreased exploration in new environment 1.47878606212906e-09 6.13080054924341e-08 1.01344607707236 0.75 5.6 5 6 liver hypoplasia 2.0087463951849e-06 4.28906150903213e-05 1.01344607707236 0.75 5.6 5 6 eyelids open at birth 2.0087463951849e-06 4.28906150903213e-05 1.01344607707236 0.75 5.6 5 6 abnormal placenta vasculature 2.0087463951849e-06 4.28906150903213e-05 1.01344607707236 0.75 5.6 5 6 curly tail 4.9909826493946e-06 9.7756451498969e-05 1.01344607707236 0.75 5.6 5 6 muscular atrophy 1.24375889611851e-05 0.000211184317685652 1.01344607707236 0.75 5.6 5 6 lymphoid hyperplasia 0.000501447961581057 0.00516501782373863 1.01344607707236 0.75 5.6 5 6 straub tail 0.000501447961581057 0.00516501782373863 1.01344607707236 0.75 5.6 5 6 enhanced coordination 0.000501447961581057 0.00516501782373863 1.01344607707236 0.75 5.6 5 6 increased stereotypic behavior 0.00128582354703102 0.0111835177386002 1.01344607707236 0.75 5.6 5 6 apnea 0.00128582354703102 0.0111835177386002 1.01344607707236 0.75 5.6 5 6 blindness 0.00128582354703102 0.0111835177386002 1.01344607707236 0.75 5.6 5 6 abnormal inner cell mass apoptosis 0.00128582354703102 0.0111835177386002 1.01344607707236 0.75 5.6 5 6 abnormal basioccipital bone morphology 0.00333605535537402 0.0237437416208666 1.01344607707236 0.75 5.6 5 6 abnormal cell proliferation 0.00333605535537402 0.0237437416208666 1.01344607707236 0.75 5.6 5 6 abnormal vascular regression 0.00333605535537402 0.0237437416208666 1.01344607707236 0.75 5.6 5 6 decreased myocardial infarction size 0.00333605535537402 0.0237437416208666 1.01344607707236 0.75 5.6 5 6 abnormal postnatal subventricular zone morphology 0.00333605535537402 0.0237437416208666 1.01344607707236 0.75 5.6 5 6 absent ductus venosus valve 0.00333605535537402 0.0237437416208666 1.01344607707236 0.75 5.6 5 6 abnormal mating frequency 0.0238163302468862 0.108802794286739 1.01344607707236 0.75 5.6 5 6 abnormal thymus involution 0.0238163302468862 0.108802794286739 1.01344607707236 0.75 5.6 5 6 myocarditis 0.0238163302468862 0.108802794286739 1.01344607707236 0.75 5.6 5 6 abnormal embryonic growth/weight/body size 0.0238163302468862 0.108802794286739 1.01344607707236 0.75 5.6 5 6 abnormal respiratory function 0.0238163302468862 0.108802794286739 1.01344607707236 0.75 5.6 5 6 increased osteosarcoma incidence 0.0238163302468862 0.108802794286739 1.01344607707236 0.75 5.6 5 6 decreased left ventricle systolic pressure 0.0238163302468862 0.108802794286739 1.01344607707236 0.75 5.6 5 6 abnormal defecation 0.0238163302468862 0.108802794286739 1.01344607707236 0.75 5.6 5 6 abnormal rostral-caudal body axis extension 0.0238163302468862 0.108802794286739 1.01344607707236 0.75 5.6 5 6 stria vascularis degeneration 0.0238163302468862 0.108802794286739 1.01344607707236 0.75 5.6 5 6 decreased cochlear nerve compound action potential 0.0238163302468862 0.108802794286739 1.01344607707236 0.75 5.6 5 6 abnormal palatine bone morphology 0.0238163302468862 0.108802794286739 1.01344607707236 0.75 5.6 5 6 hemoperitoneum 0.0238163302468862 0.108802794286739 1.01344607707236 0.75 5.6 5 6 abnormal behavioral response to addictive substance 0.0238163302468862 0.108802794286739 1.01344607707236 0.75 5.6 5 6 decreased red blood cell distribution width 0.0238163302468862 0.108802794286739 1.01344607707236 0.75 5.6 5 6 increased fibrosarcoma incidence 0.0238163302468862 0.108802794286739 1.01344607707236 0.75 5.6 5 6 persistent right dorsal aorta 0.0238163302468862 0.108802794286739 1.01344607707236 0.75 5.6 5 6 abnormal pulmonary valve cusp morphology 0.0238163302468862 0.108802794286739 1.01344607707236 0.75 5.6 5 6 prenatal growth retardation 0.0238163302468862 0.108802794286739 1.01344607707236 0.75 5.6 5 6 hydroencephaly 2.05228862736361e-12 1.32599167806934e-10 1.01050855221128 0.747826086956522 5.6 5 6 pale yolk sac 2.62527135738056e-09 1.06184756121694e-07 1.0093760125058 0.746987951807229 5.6 5 6 abnormal placenta morphology 6.44031961403789e-09 2.39108881192825e-07 1.00916993328724 0.746835443037975 5.6 5 6 decreased birth body size 3.63107034859443e-12 2.28665506129839e-10 1.00751949182632 0.745614035087719 5.6 5 6 impaired balance 5.28727525578259e-11 2.89057081291411e-09 1.00682224650326 0.745098039215686 5.6 5 6 abnormal trophoblast layer morphology 3.57306402685934e-06 7.22601363155497e-05 1.00682224650326 0.745098039215686 5.6 5 6 pale liver 2.79645532003206e-08 8.43173649524817e-07 1.00431593223387 0.743243243243243 5.6 5 6 holoprosencephaly 0.000139315307523662 0.00171134235785239 1.00379420967167 0.742857142857143 5.6 5 6 abnormal postnatal growth/weight/body size 0.000352133285701665 0.00385778115296042 1.00254880742642 0.741935483870968 5.6 5 6 small cranium 0.000352133285701665 0.00385778115296042 1.00254880742642 0.741935483870968 5.6 5 6 preaxial polydactyly 0.000352133285701665 0.00385778115296042 1.00254880742642 0.741935483870968 5.6 5 6 decreased rib number 1.36298723398891e-09 5.69820293201247e-08 1.00205904249851 0.741573033707865 5.6 5 6 increased circulating alkaline phosphatase level 3.28072196854013e-16 3.47267910499727e-14 1.0009343971085 0.740740740740741 5.6 5 6 abnormal mandible morphology 2.54770755072336e-06 5.30328245391159e-05 1.0009343971085 0.740740740740741 5.6 5 6 abnormal cell adhesion 2.54770755072336e-06 5.30328245391159e-05 1.0009343971085 0.740740740740741 5.6 5 6 abnormal neuronal precursor proliferation 2.54770755072336e-06 5.30328245391159e-05 1.0009343971085 0.740740740740741 5.6 5 6 axon degeneration 2.54770755072336e-06 5.30328245391159e-05 1.0009343971085 0.740740740740741 5.6 5 6 abnormal brain commissure morphology 0.000896279493021334 0.0083345616407124 1.0009343971085 0.740740740740741 5.6 5 6 abnormal eye muscle morphology 0.000896279493021334 0.0083345616407124 1.0009343971085 0.740740740740741 5.6 5 6 thick interventricular septum 0.000896279493021334 0.0083345616407124 1.0009343971085 0.740740740740741 5.6 5 6 short stride length 6.3165392969872e-06 0.000118138281964328 0.999933462711394 0.74 5.6 5 6 embryonic lethality during organogenesis, complete penetrance 4.00474860100142e-52 3.32060404833035e-49 0.998968275971326 0.739285714285714 5.6 5 6 atrial septal defect 1.57012647020885e-05 0.000259091106898723 0.998758452766963 0.739130434782609 5.6 5 6 abnormal corneal stroma morphology 0.00230211444384072 0.0181505853535778 0.998758452766963 0.739130434782609 5.6 5 6 abnormal hematopoietic stem cell physiology 0.00230211444384072 0.0181505853535778 0.998758452766963 0.739130434782609 5.6 5 6 abnormal optic nerve morphology 3.91490101643612e-05 0.000577941618895243 0.997359631404544 0.738095238095238 5.6 5 6 disheveled coat 3.91490101643612e-05 0.000577941618895243 0.997359631404544 0.738095238095238 5.6 5 6 abnormal pancreas morphology 3.91490101643612e-05 0.000577941618895243 0.997359631404544 0.738095238095238 5.6 5 6 abnormal social investigation 1.43436411676728e-08 4.6640271117106e-07 0.996555309121153 0.7375 5.6 5 6 persistence of hyaloid vascular system 9.79713825748776e-05 0.00126271406297932 0.995666321334248 0.736842105263158 5.6 5 6 small superior vagus ganglion 0.00598627300810375 0.0370910758979354 0.995666321334248 0.736842105263158 5.6 5 6 increased malignant tumor incidence 0.00598627300810375 0.0370910758979354 0.995666321334248 0.736842105263158 5.6 5 6 decreased tumor incidence 0.00598627300810375 0.0370910758979354 0.995666321334248 0.736842105263158 5.6 5 6 abnormal response to novelty 0.00598627300810375 0.0370910758979354 0.995666321334248 0.736842105263158 5.6 5 6 increased liver adenoma incidence 0.00598627300810375 0.0370910758979354 0.995666321334248 0.736842105263158 5.6 5 6 abnormal photoreceptor inner segment morphology 0.00598627300810375 0.0370910758979354 0.995666321334248 0.736842105263158 5.6 5 6 absent amnion 0.00598627300810375 0.0370910758979354 0.995666321334248 0.736842105263158 5.6 5 6 abnormal neuromuscular synapse morphology 8.62722790391372e-08 2.3712960675122e-06 0.994678557126575 0.736111111111111 5.6 5 6 pericardial edema 2.1190457086859e-07 5.6075810642087e-06 0.993574585365058 0.735294117647059 5.6 5 6 abnormal nervous system development 0.000246269867378215 0.00282302440139774 0.993574585365058 0.735294117647059 5.6 5 6 increased T cell derived lymphoma incidence 1.10948908924729e-05 0.000190993363979422 0.992763504070883 0.73469387755102 5.6 5 6 increased tumor incidence 2.98407914982465e-12 1.90330689363816e-10 0.991651537780481 0.733870967741935 5.6 5 6 trabecula carnea hypoplasia 2.7563641700141e-05 0.000431223639805665 0.990925053137418 0.733333333333333 5.6 5 6 liver hemorrhage 0.000622463608094561 0.00607207147111852 0.990925053137418 0.733333333333333 5.6 5 6 abnormal optic cup morphology 0.000622463608094561 0.00607207147111852 0.990925053137418 0.733333333333333 5.6 5 6 abnormal seizure response to electrical stimulation 0.0158423591694995 0.0789736842367333 0.990925053137418 0.733333333333333 5.6 5 6 absent egg cylinders 0.0158423591694995 0.0789736842367333 0.990925053137418 0.733333333333333 5.6 5 6 delayed intramembranous bone ossification 0.0158423591694995 0.0789736842367333 0.990925053137418 0.733333333333333 5.6 5 6 dilated ureter 0.0158423591694995 0.0789736842367333 0.990925053137418 0.733333333333333 5.6 5 6 abnormal glial cell morphology 0.0158423591694995 0.0789736842367333 0.990925053137418 0.733333333333333 5.6 5 6 abnormal zygomatic bone morphology 0.0158423591694995 0.0789736842367333 0.990925053137418 0.733333333333333 5.6 5 6 abnormal Muller cell morphology 0.0158423591694995 0.0789736842367333 0.990925053137418 0.733333333333333 5.6 5 6 decreased thymocyte apoptosis 0.0158423591694995 0.0789736842367333 0.990925053137418 0.733333333333333 5.6 5 6 absent chorion 0.0158423591694995 0.0789736842367333 0.990925053137418 0.733333333333333 5.6 5 6 decreased anxiety-related response 5.18237566945322e-12 3.18300234018886e-10 0.988727880070594 0.731707317073171 5.6 5 6 thick ventricular wall 6.86815469792697e-05 0.000916060847779803 0.988727880070594 0.731707317073171 5.6 5 6 impaired coordination 4.73335946357538e-31 1.56989755541917e-28 0.988061107897136 0.73121387283237 5.6 5 6 increased rib number 4.35745554745417e-08 1.25308331494708e-06 0.98746028022435 0.730769230769231 5.6 5 6 thick skin 0.00158430649369894 0.013269233680391 0.98746028022435 0.730769230769231 5.6 5 6 no spontaneous movement 0.00158430649369894 0.013269233680391 0.98746028022435 0.730769230769231 5.6 5 6 decreased circulating glycerol level 0.00158430649369894 0.013269233680391 0.98746028022435 0.730769230769231 5.6 5 6 abnormal Mullerian duct morphology 0.00158430649369894 0.013269233680391 0.98746028022435 0.730769230769231 5.6 5 6 overriding aortic valve 1.93574104714276e-05 0.000315747924902794 0.985294797153683 0.729166666666667 5.6 5 6 abnormal neural tube morphology 4.67893951077577e-15 4.56425962080578e-13 0.984252157156695 0.728395061728395 5.6 5 6 perinatal lethality, complete penetrance 3.00083103900506e-19 4.26546697687147e-17 0.983312312652367 0.727699530516432 5.6 5 6 abnormal locomotor coordination 0.000431302723522688 0.00460457306765102 0.982735589888349 0.727272727272727 5.6 5 6 abnormal motor coordination/ balance 1.07123036131472e-09 4.55501798935107e-08 0.982735589888348 0.727272727272727 5.6 5 6 abnormal head morphology 5.49861032708333e-06 0.00010401363641536 0.982735589888348 0.727272727272727 5.6 5 6 abnormal embryo turning 5.49861032708333e-06 0.00010401363641536 0.982735589888348 0.727272727272727 5.6 5 6 abnormal learning/memory/conditioning 5.49861032708333e-06 0.00010401363641536 0.982735589888348 0.727272727272727 5.6 5 6 lethality, incomplete penetrance 4.8035718080095e-05 0.000680848140878839 0.982735589888348 0.727272727272727 5.6 5 6 abnormal germ layer development 0.00406907712221464 0.027960854534555 0.982735589888348 0.727272727272727 5.6 5 6 abnormal chorion morphology 0.00406907712221464 0.027960854534555 0.982735589888348 0.727272727272727 5.6 5 6 increased myocardial infarction size 0.00406907712221464 0.027960854534555 0.982735589888348 0.727272727272727 5.6 5 6 decreased cardiac output 0.00406907712221464 0.027960854534555 0.982735589888348 0.727272727272727 5.6 5 6 abnormal temporal bone morphology 0.00406907712221464 0.027960854534555 0.982735589888348 0.727272727272727 5.6 5 6 abnormal ear position 0.0430782166286468 0.162729026368654 0.982735589888348 0.727272727272727 5.6 5 6 abnormal thrombopoiesis 0.0430782166286468 0.162729026368654 0.982735589888348 0.727272727272727 5.6 5 6 decreased atrioventricular cushion size 0.0430782166286468 0.162729026368654 0.982735589888348 0.727272727272727 5.6 5 6 abnormal stomach epithelium morphology 0.0430782166286468 0.162729026368654 0.982735589888348 0.727272727272727 5.6 5 6 abnormal large intestine morphology 0.0430782166286468 0.162729026368654 0.982735589888348 0.727272727272727 5.6 5 6 abnormal enteric ganglia morphology 0.0430782166286468 0.162729026368654 0.982735589888348 0.727272727272727 5.6 5 6 abnormal glossopharyngeal ganglion morphology 0.0430782166286468 0.162729026368654 0.982735589888348 0.727272727272727 5.6 5 6 abnormal food preference 0.0430782166286468 0.162729026368654 0.982735589888348 0.727272727272727 5.6 5 6 abnormal hemoglobin 0.0430782166286468 0.162729026368654 0.982735589888348 0.727272727272727 5.6 5 6 secondary sex reversal 0.0430782166286468 0.162729026368654 0.982735589888348 0.727272727272727 5.6 5 6 fused joints 0.0430782166286468 0.162729026368654 0.982735589888348 0.727272727272727 5.6 5 6 loss of cortex neurons 0.0430782166286468 0.162729026368654 0.982735589888348 0.727272727272727 5.6 5 6 abnormal radial glial cell morphology 0.0430782166286468 0.162729026368654 0.982735589888348 0.727272727272727 5.6 5 6 pharyngeal arch hypoplasia 0.0430782166286468 0.162729026368654 0.982735589888348 0.727272727272727 5.6 5 6 abnormal dorsal-ventral polarity of the somites 0.0430782166286468 0.162729026368654 0.982735589888348 0.727272727272727 5.6 5 6 increased glycogen level 0.0430782166286468 0.162729026368654 0.982735589888348 0.727272727272727 5.6 5 6 palatal shelf hypoplasia 0.0430782166286468 0.162729026368654 0.982735589888348 0.727272727272727 5.6 5 6 abnormal palatal shelf elevation 0.0430782166286468 0.162729026368654 0.982735589888348 0.727272727272727 5.6 5 6 aberrant origin of the right subclavian artery 0.0430782166286468 0.162729026368654 0.982735589888348 0.727272727272727 5.6 5 6 aorta dilation 0.0430782166286468 0.162729026368654 0.982735589888348 0.727272727272727 5.6 5 6 abnormal pulmonary alveolar sac morphology 0.0430782166286468 0.162729026368654 0.982735589888348 0.727272727272727 5.6 5 6 abnormal brain ependyma motile cilium morphology 0.0430782166286468 0.162729026368654 0.982735589888348 0.727272727272727 5.6 5 6 decreased embryonic cilium length 0.0430782166286468 0.162729026368654 0.982735589888348 0.727272727272727 5.6 5 6 abnormal phrenic nerve innervation pattern to diaphragm 0.0430782166286468 0.162729026368654 0.982735589888348 0.727272727272727 5.6 5 6 astrocytosis 1.84435255117514e-07 4.90676681395525e-06 0.981052823467307 0.726027397260274 5.6 5 6 prenatal lethality 1.57132986362076e-06 3.42866932961108e-05 0.980754268134541 0.725806451612903 5.6 5 6 abnormal cervical vertebrae morphology 1.35671525108966e-05 0.00022958021680854 0.980326924226857 0.725490196078431 5.6 5 6 small spleen 6.34291299168127e-09 2.3726309874898e-07 0.980035766839205 0.725274725274725 5.6 5 6 abnormal gait 8.76315871889616e-27 1.98166884665947e-24 0.97955521581104 0.724919093851133 5.6 5 6 abnormal blood vessel morphology 2.7665079594184e-13 2.0240260438392e-11 0.978499660621588 0.724137931034483 5.6 5 6 aphagia 0.00108884955667989 0.00969056626919942 0.978499660621588 0.724137931034483 5.6 5 6 decreased trophoblast giant cell number 0.00108884955667989 0.00969056626919942 0.978499660621588 0.724137931034483 5.6 5 6 abnormal embryonic erythropoiesis 0.00108884955667989 0.00969056626919942 0.978499660621588 0.724137931034483 5.6 5 6 short radius 0.000298412148373141 0.00332125377663618 0.975911037180791 0.722222222222222 5.6 5 6 abnormal trophoblast giant cell morphology 0.000298412148373141 0.00332125377663618 0.975911037180791 0.722222222222222 5.6 5 6 abnormal heart shape 0.0105793643173073 0.0608466329232416 0.975911037180791 0.722222222222222 5.6 5 6 abnormal mitral valve morphology 0.0105793643173073 0.0608466329232416 0.975911037180791 0.722222222222222 5.6 5 6 delayed kidney development 0.0105793643173073 0.0608466329232416 0.975911037180791 0.722222222222222 5.6 5 6 right pulmonary isomerism 0.0105793643173073 0.0608466329232416 0.975911037180791 0.722222222222222 5.6 5 6 abnormal phrenic nerve morphology 0.0105793643173073 0.0608466329232416 0.975911037180791 0.722222222222222 5.6 5 6 decreased cellular sensitivity to gamma-irradiation 0.0105793643173073 0.0608466329232416 0.975911037180791 0.722222222222222 5.6 5 6 abnormal anterior eye segment morphology 0.0105793643173073 0.0608466329232416 0.975911037180791 0.722222222222222 5.6 5 6 increased gastrointestinal tumor incidence 0.0105793643173073 0.0608466329232416 0.975911037180791 0.722222222222222 5.6 5 6 increased adipocyte glucose uptake 0.0105793643173073 0.0608466329232416 0.975911037180791 0.722222222222222 5.6 5 6 hunched posture 9.15579486736368e-08 2.50275161896342e-06 0.97496078300632 0.721518987341772 5.6 5 6 abnormal embryonic tissue morphology 3.35624219822233e-13 2.38532927659373e-11 0.974378994736237 0.72108843537415 5.6 5 6 lethality throughout fetal growth and development, complete penetrance 1.25169700833573e-16 1.41527104919779e-14 0.974330614448514 0.721052631578947 5.6 5 6 prenatal lethality, incomplete penetrance 1.29668994885171e-25 2.4811663444374e-23 0.973441626661608 0.720394736842105 5.6 5 6 decreased respiratory quotient 2.33820807094362e-05 0.00037403810781172 0.972908233989465 0.72 5.6 5 6 mandible hypoplasia 0.0027670643170866 0.0204245474443707 0.972908233989465 0.72 5.6 5 6 abnormal egg cylinder morphology 0.0027670643170866 0.0204245474443707 0.972908233989465 0.72 5.6 5 6 abnormal preimplantation embryo development 0.0027670643170866 0.0204245474443707 0.972908233989465 0.72 5.6 5 6 decreased body length 5.11450051077308e-23 9.08737144324861e-21 0.971527382886885 0.718978102189781 5.6 5 6 decreased caudal vertebrae number 1.89446859333245e-06 4.09781793557779e-05 0.971219157194344 0.71875 5.6 5 6 bradykinesia 0.00074790736345667 0.00708731263466082 0.971219157194344 0.71875 5.6 5 6 embryonic lethality during organogenesis, incomplete penetrance 2.32474957067225e-19 3.40165562179248e-17 0.96938320415617 0.717391304347826 5.6 5 6 postnatal lethality 2.45200168487538e-14 2.06757769190763e-12 0.968675366840247 0.716867469879518 5.6 5 6 internal hemorrhage 1.32508316100011e-06 2.94298603838195e-05 0.96806789451688 0.716417910447761 5.6 5 6 decreased bone mineral content 1.56263164061397e-17 1.8509743838225e-15 0.967970932588343 0.716346153846154 5.6 5 6 decreased heart weight 1.09808745705488e-07 2.96901364067829e-06 0.967569917204886 0.716049382716049 5.6 5 6 impaired righting response 9.20950328195367e-09 3.24945239912904e-07 0.967218712153269 0.715789473684211 5.6 5 6 kinked tail 2.6757910363392e-09 1.07355325853125e-07 0.967079263088657 0.715686274509804 5.6 5 6 anemia 1.10263976998757e-17 1.37140821392203e-15 0.967016477964779 0.71563981042654 5.6 5 6 increased carcinoma incidence 0.000513656267014599 0.00524730991457419 0.965186740068914 0.714285714285714 5.6 5 6 decreased triglyceride level 0.000513656267014599 0.00524730991457419 0.965186740068914 0.714285714285714 5.6 5 6 decreased circulating thyroxine level 0.000513656267014599 0.00524730991457419 0.965186740068914 0.714285714285714 5.6 5 6 trunk curl 0.00709178105602353 0.0427868454201078 0.965186740068914 0.714285714285714 5.6 5 6 increased incidence of induced tumors 0.00709178105602353 0.0427868454201078 0.965186740068914 0.714285714285714 5.6 5 6 vascular ring 0.00709178105602353 0.0427868454201078 0.965186740068914 0.714285714285714 5.6 5 6 embryonic lethality at implantation, complete penetrance 0.00709178105602353 0.0427868454201078 0.965186740068914 0.714285714285714 5.6 5 6 increased circulating LDL cholesterol level 4.0013709418814e-05 0.000584997133005415 0.965186740068914 0.714285714285714 5.6 5 6 absent kidney 4.0013709418814e-05 0.000584997133005415 0.965186740068914 0.714285714285714 5.6 5 6 rib bifurcation 0.00188335832162201 0.0151368459613401 0.965186740068914 0.714285714285714 5.6 5 6 small superior cervical ganglion 0.00188335832162201 0.0151368459613401 0.965186740068914 0.714285714285714 5.6 5 6 abnormal somite shape 0.00188335832162201 0.0151368459613401 0.965186740068914 0.714285714285714 5.6 5 6 increased bone resorption 0.00188335832162201 0.0151368459613401 0.965186740068914 0.714285714285714 5.6 5 6 prolonged QRS complex duration 0.00188335832162201 0.0151368459613401 0.965186740068914 0.714285714285714 5.6 5 6 megacephaly 0.0279869801294611 0.12139078129387 0.965186740068914 0.714285714285714 5.6 5 6 abnormal kidney blood vessel morphology 0.0279869801294611 0.12139078129387 0.965186740068914 0.714285714285714 5.6 5 6 abnormal pinna reflex 0.0279869801294611 0.12139078129387 0.965186740068914 0.714285714285714 5.6 5 6 extended life span 0.0279869801294611 0.12139078129387 0.965186740068914 0.714285714285714 5.6 5 6 abnormal endplate potential 0.0279869801294611 0.12139078129387 0.965186740068914 0.714285714285714 5.6 5 6 increased lactate dehydrogenase level 0.0279869801294611 0.12139078129387 0.965186740068914 0.714285714285714 5.6 5 6 amyloid beta deposits 0.0279869801294611 0.12139078129387 0.965186740068914 0.714285714285714 5.6 5 6 vascular smooth muscle hypoplasia 0.0279869801294611 0.12139078129387 0.965186740068914 0.714285714285714 5.6 5 6 abnormal maternal decidual layer morphology 0.0279869801294611 0.12139078129387 0.965186740068914 0.714285714285714 5.6 5 6 abnormal iris pigmentation 0.0279869801294611 0.12139078129387 0.965186740068914 0.714285714285714 5.6 5 6 decreased cornea thickness 0.0279869801294611 0.12139078129387 0.965186740068914 0.714285714285714 5.6 5 6 increased pulmonary respiratory rate 0.0279869801294611 0.12139078129387 0.965186740068914 0.714285714285714 5.6 5 6 decreased tongue size 0.0279869801294611 0.12139078129387 0.965186740068914 0.714285714285714 5.6 5 6 sternebra fusion 0.0279869801294611 0.12139078129387 0.965186740068914 0.714285714285714 5.6 5 6 increased lung compliance 0.0279869801294611 0.12139078129387 0.965186740068914 0.714285714285714 5.6 5 6 testis degeneration 0.0279869801294611 0.12139078129387 0.965186740068914 0.714285714285714 5.6 5 6 cochlear degeneration 0.122815569743682 0.333701507086192 0.965186740068914 0.714285714285714 5.6 5 6 cellular necrosis 0.122815569743682 0.333701507086192 0.965186740068914 0.714285714285714 5.6 5 6 absent hair follicles 0.122815569743682 0.333701507086192 0.965186740068914 0.714285714285714 5.6 5 6 polyphalangy 0.122815569743682 0.333701507086192 0.965186740068914 0.714285714285714 5.6 5 6 abnormal foot pad morphology 0.122815569743682 0.333701507086192 0.965186740068914 0.714285714285714 5.6 5 6 mammary gland hyperplasia 0.122815569743682 0.333701507086192 0.965186740068914 0.714285714285714 5.6 5 6 small L4 dorsal root ganglion 0.122815569743682 0.333701507086192 0.965186740068914 0.714285714285714 5.6 5 6 limp posture 0.122815569743682 0.333701507086192 0.965186740068914 0.714285714285714 5.6 5 6 abnormal axial mesoderm 0.122815569743682 0.333701507086192 0.965186740068914 0.714285714285714 5.6 5 6 absent amniotic folds 0.122815569743682 0.333701507086192 0.965186740068914 0.714285714285714 5.6 5 6 increased chemically-elicited antinociception 0.122815569743682 0.333701507086192 0.965186740068914 0.714285714285714 5.6 5 6 abnormal melanocyte morphology 0.122815569743682 0.333701507086192 0.965186740068914 0.714285714285714 5.6 5 6 decreased lateral semicircular canal size 0.122815569743682 0.333701507086192 0.965186740068914 0.714285714285714 5.6 5 6 decreased cholesterol efflux 0.122815569743682 0.333701507086192 0.965186740068914 0.714285714285714 5.6 5 6 anuria 0.122815569743682 0.333701507086192 0.965186740068914 0.714285714285714 5.6 5 6 abnormal central pattern generator function 0.122815569743682 0.333701507086192 0.965186740068914 0.714285714285714 5.6 5 6 abnormal nephron morphology 0.122815569743682 0.333701507086192 0.965186740068914 0.714285714285714 5.6 5 6 abnormal organ of Corti supporting cell morphology 0.122815569743682 0.333701507086192 0.965186740068914 0.714285714285714 5.6 5 6 absent deltoid tuberosity 0.122815569743682 0.333701507086192 0.965186740068914 0.714285714285714 5.6 5 6 absent ulna 0.122815569743682 0.333701507086192 0.965186740068914 0.714285714285714 5.6 5 6 abnormal cochlear nerve compound action potential 0.122815569743682 0.333701507086192 0.965186740068914 0.714285714285714 5.6 5 6 abnormal talus morphology 0.122815569743682 0.333701507086192 0.965186740068914 0.714285714285714 5.6 5 6 increased thyroid-stimulating hormone level 0.122815569743682 0.333701507086192 0.965186740068914 0.714285714285714 5.6 5 6 abnormal renal/urinary system physiology 0.122815569743682 0.333701507086192 0.965186740068914 0.714285714285714 5.6 5 6 abnormal renal filtration rate 0.122815569743682 0.333701507086192 0.965186740068914 0.714285714285714 5.6 5 6 absent popliteal lymph nodes 0.122815569743682 0.333701507086192 0.965186740068914 0.714285714285714 5.6 5 6 decreased behavioral withdrawal response 0.122815569743682 0.333701507086192 0.965186740068914 0.714285714285714 5.6 5 6 abnormal sperm annulus morphology 0.122815569743682 0.333701507086192 0.965186740068914 0.714285714285714 5.6 5 6 decreased DN2 thymocyte number 0.122815569743682 0.333701507086192 0.965186740068914 0.714285714285714 5.6 5 6 decreased DN4 thymocyte number 0.122815569743682 0.333701507086192 0.965186740068914 0.714285714285714 5.6 5 6 decreased skeletal muscle glycogen level 0.122815569743682 0.333701507086192 0.965186740068914 0.714285714285714 5.6 5 6 heart right ventricle outflow tract stenosis 0.122815569743682 0.333701507086192 0.965186740068914 0.714285714285714 5.6 5 6 coronary fistula 0.122815569743682 0.333701507086192 0.965186740068914 0.714285714285714 5.6 5 6 small lung lobe 0.122815569743682 0.333701507086192 0.965186740068914 0.714285714285714 5.6 5 6 small tail bud 0.122815569743682 0.333701507086192 0.965186740068914 0.714285714285714 5.6 5 6 impaired mammary gland growth during pregnancy 0.122815569743682 0.333701507086192 0.965186740068914 0.714285714285714 5.6 5 6 decreased CD8-positive, naive alpha-beta T cell number 0.122815569743682 0.333701507086192 0.965186740068914 0.714285714285714 5.6 5 6 abnormal Mullerian duct topology 0.122815569743682 0.333701507086192 0.965186740068914 0.714285714285714 5.6 5 6 absent connection between subcutaneous lymph vessels and lymph sac 0.122815569743682 0.333701507086192 0.965186740068914 0.714285714285714 5.6 5 6 decreased collagen level 0.122815569743682 0.333701507086192 0.965186740068914 0.714285714285714 5.6 5 6 abnormal vitelline vasculature morphology 3.84559886667675e-10 1.77146799645526e-08 0.963508154434011 0.71304347826087 5.6 5 6 abnormal nervous system physiology 3.84559886667675e-10 1.77146799645526e-08 0.963508154434011 0.71304347826087 5.6 5 6 perinatal lethality, incomplete penetrance 1.91583175483889e-18 2.53702119562555e-16 0.962624297396164 0.712389380530973 5.6 5 6 increased anxiety-related response 6.73497327514027e-12 4.08615756631986e-10 0.962409224270154 0.712230215827338 5.6 5 6 abnormal thoracic vertebrae morphology 7.88193967045935e-06 0.000143711788376386 0.961914920611053 0.711864406779661 5.6 5 6 distended pericardium 2.7745758437549e-05 0.000431359838208769 0.961474483376341 0.711538461538462 5.6 5 6 decreased kidney weight 2.7745758437549e-05 0.000431359838208769 0.961474483376341 0.711538461538462 5.6 5 6 abnormal myocardial fiber morphology 1.09402176728297e-08 3.77969325849499e-07 0.961206588563475 0.711340206185567 5.6 5 6 hemorrhage 6.67111638056409e-19 9.21911222036288e-17 0.960258126928136 0.71063829787234 5.6 5 6 decreased hair follicle number 0.000352822195898893 0.00385778115296042 0.960106809858025 0.710526315789474 5.6 5 6 abnormal reproductive system physiology 0.000352822195898893 0.00385778115296042 0.960106809858025 0.710526315789474 5.6 5 6 double outlet right ventricle 2.22848590832776e-09 9.0874732737136e-08 0.959774477975069 0.710280373831776 5.6 5 6 lethargy 2.63749784313605e-08 8.09972331456903e-07 0.958959728842663 0.709677419354839 5.6 5 6 abnormal retinal photoreceptor layer morphology 0.00128327106283275 0.0111835177386002 0.958959728842663 0.709677419354839 5.6 5 6 decreased neuronal precursor cell number 0.00128327106283275 0.0111835177386002 0.958959728842663 0.709677419354839 5.6 5 6 decreased total body fat amount 4.61847148181831e-26 9.19075824881844e-24 0.958829222619358 0.709580838323353 5.6 5 6 abnormal rostral-caudal axis patterning 1.92320157680662e-05 0.000314734468572794 0.95816720014114 0.709090909090909 5.6 5 6 abnormal adrenal gland morphology 0.00477024947894998 0.0318718842422328 0.957143517235006 0.708333333333333 5.6 5 6 abnormal sensory capabilities/reflexes/nociception 0.00477024947894998 0.0318718842422328 0.957143517235006 0.708333333333333 5.6 5 6 abnormal cardiac muscle contractility 0.00477024947894998 0.0318718842422328 0.957143517235006 0.708333333333333 5.6 5 6 abnormal tumor morphology 0.00477024947894998 0.0318718842422328 0.957143517235006 0.708333333333333 5.6 5 6 increased hemangiosarcoma incidence 0.00477024947894998 0.0318718842422328 0.957143517235006 0.708333333333333 5.6 5 6 abnormal retinal ganglion layer morphology 0.00477024947894998 0.0318718842422328 0.957143517235006 0.708333333333333 5.6 5 6 anophthalmia 6.35518824657204e-08 1.77623941161213e-06 0.956510904203126 0.707865168539326 5.6 5 6 neonatal lethality, incomplete penetrance 2.3531426836503e-20 3.90229495038674e-18 0.956277324006739 0.707692307692308 5.6 5 6 abnormal mammary gland development 0.000242417734370678 0.00278528459236517 0.955770284068241 0.707317073170732 5.6 5 6 short humerus 0.000242417734370678 0.00278528459236517 0.955770284068241 0.707317073170732 5.6 5 6 decreased circulating serum albumin level 1.28845429856186e-08 4.24507293731474e-07 0.955437379058117 0.707070707070707 5.6 5 6 decreased erythrocyte cell number 8.05197532031208e-13 5.48747633130857e-11 0.95535044208095 0.707006369426752 5.6 5 6 lung hemorrhage 0.000875381578269429 0.00818613412009475 0.953831601950456 0.705882352941177 5.6 5 6 abnormal endoderm development 0.000875381578269429 0.00818613412009475 0.953831601950456 0.705882352941177 5.6 5 6 abnormal vagus nerve morphology 0.0183813960146811 0.0897449645691265 0.953831601950456 0.705882352941177 5.6 5 6 abnormal dorsal-ventral axis patterning 0.0183813960146811 0.0897449645691265 0.953831601950456 0.705882352941177 5.6 5 6 abnormal testis development 0.0183813960146811 0.0897449645691265 0.953831601950456 0.705882352941177 5.6 5 6 decreased growth hormone level 0.0183813960146811 0.0897449645691265 0.953831601950456 0.705882352941177 5.6 5 6 decreased body fat mass 0.0183813960146811 0.0897449645691265 0.953831601950456 0.705882352941177 5.6 5 6 abnormal extraembryonic tissue morphology 8.99999120155435e-09 3.19821115912378e-07 0.953831601950456 0.705882352941177 5.6 5 6 small lung 4.69379083859312e-05 0.00066910055650432 0.953831601950456 0.705882352941177 5.6 5 6 abnormal eye morphology 2.24007143407748e-11 1.26640402096994e-09 0.952687918974496 0.705035971223022 5.6 5 6 abnormal maternal nurturing 9.23402629569314e-06 0.000163484985128375 0.952528553313911 0.704918032786885 5.6 5 6 decreased blood urea nitrogen level 0.000166623491858237 0.00199747439034874 0.952025102704337 0.704545454545455 5.6 5 6 decreased platelet aggregation 3.24148356323953e-05 0.000494674255433027 0.950887677253078 0.703703703703704 5.6 5 6 thin epidermis 0.00321837062030826 0.0232039311861435 0.950887677253078 0.703703703703704 5.6 5 6 abnormal type II pneumocyte morphology 0.00321837062030826 0.0232039311861435 0.950887677253078 0.703703703703704 5.6 5 6 abnormal single cell response 0.00321837062030826 0.0232039311861435 0.950887677253078 0.703703703703704 5.6 5 6 decreased circulating fructosamine level 0.00321837062030826 0.0232039311861435 0.950887677253078 0.703703703703704 5.6 5 6 abnormal vocalization 0.000597809622052602 0.00590546921984672 0.949535063202931 0.702702702702703 5.6 5 6 increased erythroid progenitor cell number 0.000597809622052602 0.00590546921984672 0.949535063202931 0.702702702702703 5.6 5 6 abnormal heart development 1.57361217804145e-12 1.03009481391529e-10 0.949303920295628 0.70253164556962 5.6 5 6 cleft palate 1.27622129599887e-10 6.54556798721072e-09 0.948977497105924 0.702290076335878 5.6 5 6 abnormal innervation 0.000114575555147624 0.00145411578280466 0.948758029599655 0.702127659574468 5.6 5 6 incomplete embryo turning 2.23877981773468e-05 0.000360450795897413 0.94825363936595 0.701754385964912 5.6 5 6 abnormal facial morphology 2.23877981773468e-05 0.000360450795897413 0.94825363936595 0.701754385964912 5.6 5 6 decreased white adipose tissue amount 4.43177816077641e-06 8.81923853994506e-05 0.947899813381112 0.701492537313433 5.6 5 6 hypoactivity 2.0091211140635e-27 4.99768877123296e-25 0.946241430051646 0.70026525198939 5.6 5 6 intracranial hemorrhage 1.5464731151921e-05 0.000257314506624773 0.945883005267535 0.7 5.6 5 6 abnormal pancreatic beta cell morphology 0.000408690092736008 0.00437254454056267 0.945883005267535 0.7 5.6 5 6 abnormal lactation 0.00217708343671233 0.017287702145151 0.945883005267535 0.7 5.6 5 6 abnormal circulating enzyme level 0.0121701141978065 0.0684706935924497 0.945883005267535 0.7 5.6 5 6 increased mammary adenocarcinoma incidence 0.0121701141978065 0.0684706935924497 0.945883005267535 0.7 5.6 5 6 abnormal hyoid bone morphology 0.0121701141978065 0.0684706935924497 0.945883005267535 0.7 5.6 5 6 abnormal lens epithelium morphology 0.0121701141978065 0.0684706935924497 0.945883005267535 0.7 5.6 5 6 abnormal heart right ventricle morphology 0.0121701141978065 0.0684706935924497 0.945883005267535 0.7 5.6 5 6 abnormal incus morphology 0.0121701141978065 0.0684706935924497 0.945883005267535 0.7 5.6 5 6 abnormal response to tactile stimuli 0.0121701141978065 0.0684706935924497 0.945883005267535 0.7 5.6 5 6 enhanced behavioral response to xenobiotic 0.0121701141978065 0.0684706935924497 0.945883005267535 0.7 5.6 5 6 abnormal neuron proliferation 0.0121701141978065 0.0684706935924497 0.945883005267535 0.7 5.6 5 6 retarded hair growth 0.076021505285449 0.234486728353912 0.945883005267535 0.7 5.6 5 6 enlarged testis 0.076021505285449 0.234486728353912 0.945883005267535 0.7 5.6 5 6 abnormal mammary gland physiology 0.076021505285449 0.234486728353912 0.945883005267535 0.7 5.6 5 6 alcohol preference 0.076021505285449 0.234486728353912 0.945883005267535 0.7 5.6 5 6 ketoaciduria 0.076021505285449 0.234486728353912 0.945883005267535 0.7 5.6 5 6 impaired social transmission of food preference 0.076021505285449 0.234486728353912 0.945883005267535 0.7 5.6 5 6 impaired basement membrane formation 0.076021505285449 0.234486728353912 0.945883005267535 0.7 5.6 5 6 abnormal tibialis anterior morphology 0.076021505285449 0.234486728353912 0.945883005267535 0.7 5.6 5 6 intestinal hypoperistalsis 0.076021505285449 0.234486728353912 0.945883005267535 0.7 5.6 5 6 cochlear ganglion hypoplasia 0.076021505285449 0.234486728353912 0.945883005267535 0.7 5.6 5 6 abnormal embryonic erythrocyte morphology 0.076021505285449 0.234486728353912 0.945883005267535 0.7 5.6 5 6 abnormal deltoid tuberosity morphology 0.076021505285449 0.234486728353912 0.945883005267535 0.7 5.6 5 6 decreased cochlear inner hair cell number 0.076021505285449 0.234486728353912 0.945883005267535 0.7 5.6 5 6 decreased thyroxine level 0.076021505285449 0.234486728353912 0.945883005267535 0.7 5.6 5 6 ventricular premature beat 0.076021505285449 0.234486728353912 0.945883005267535 0.7 5.6 5 6 impaired behavioral response to morphine 0.076021505285449 0.234486728353912 0.945883005267535 0.7 5.6 5 6 abnormal sperm principal piece morphology 0.076021505285449 0.234486728353912 0.945883005267535 0.7 5.6 5 6 increased circulating fructosamine level 0.076021505285449 0.234486728353912 0.945883005267535 0.7 5.6 5 6 increased kidney iron level 0.076021505285449 0.234486728353912 0.945883005267535 0.7 5.6 5 6 abnormal left subclavian artery morphology 0.076021505285449 0.234486728353912 0.945883005267535 0.7 5.6 5 6 abnormal inferior vena cava valve morphology 0.076021505285449 0.234486728353912 0.945883005267535 0.7 5.6 5 6 thick aortic valve cusps 0.076021505285449 0.234486728353912 0.945883005267535 0.7 5.6 5 6 thick aortic valve 0.076021505285449 0.234486728353912 0.945883005267535 0.7 5.6 5 6 abnormal adaptive thermogenesis 0.076021505285449 0.234486728353912 0.945883005267535 0.7 5.6 5 6 abnormal circadian temperature homeostasis 0.076021505285449 0.234486728353912 0.945883005267535 0.7 5.6 5 6 decreased circulating lactate level 0.076021505285449 0.234486728353912 0.945883005267535 0.7 5.6 5 6 abnormal bone structure 1.110532664921e-14 1.00452727417854e-12 0.945182869808418 0.699481865284974 5.6 5 6 respiratory distress 2.62454594463104e-13 1.94882329470738e-11 0.945101929292913 0.699421965317919 5.6 5 6 abnormal craniofacial morphology 1.74538276908387e-08 5.5662046642258e-07 0.944571100960646 0.699029126213592 5.6 5 6 short tail 4.26687252974627e-07 1.03047042890717e-05 0.944254979440913 0.698795180722892 5.6 5 6 decreased susceptibility to hepatic steatosis 1.06843314469801e-05 0.000185207487626223 0.94373814584516 0.698412698412698 5.6 5 6 abnormal left-right axis patterning 0.000279681829335831 0.00314089639039674 0.942740536811497 0.697674418604651 5.6 5 6 increased bone mineral content 8.45239398249553e-09 3.02522734265578e-07 0.942163937094793 0.697247706422018 5.6 5 6 decreased brown adipose tissue amount 0.00147609803530483 0.0124890947714992 0.941788273643001 0.696969696969697 5.6 5 6 single kidney 0.00147609803530483 0.0124890947714992 0.941788273643001 0.696969696969697 5.6 5 6 abnormal QRS complex 0.00147609803530483 0.0124890947714992 0.941788273643001 0.696969696969697 5.6 5 6 increased mean corpuscular hemoglobin 4.16033237589055e-08 1.21750903353267e-06 0.941788273643001 0.696969696969697 5.6 5 6 abnormal rib morphology 1.70853753754499e-10 8.58583257503669e-09 0.940878333281993 0.696296296296296 5.6 5 6 abnormal cranial nerve morphology 0.0081078489584979 0.0487156383677863 0.940007955545377 0.695652173913043 5.6 5 6 abnormal basicranium morphology 0.0081078489584979 0.0487156383677863 0.940007955545377 0.695652173913043 5.6 5 6 perimembraneous ventricular septal defect 5.10273658563825e-06 9.91645098185558e-05 0.940007955545377 0.695652173913043 5.6 5 6 decreased body weight 4.0056700551189e-85 9.96410426210827e-82 0.939770675669684 0.695476575121163 5.6 5 6 increased circulating HDL cholesterol level 2.00957282906416e-08 6.28781435509069e-07 0.939448427000409 0.695238095238095 5.6 5 6 hydrops fetalis 3.52744031981879e-06 7.1628635065708e-05 0.938375997289222 0.694444444444444 5.6 5 6 abnormal craniofacial development 0.000131342850211536 0.00162544945224475 0.937609976066945 0.693877551020408 5.6 5 6 abnormal hepatocyte morphology 9.70486373709227e-09 3.40011951352352e-07 0.937361536751612 0.693693693693694 5.6 5 6 small kidney 3.39639768464367e-07 8.53356821300629e-06 0.936669859112332 0.693181818181818 5.6 5 6 cyanosis 5.74445199719567e-14 4.53629344222992e-12 0.936030057295999 0.692708333333333 5.6 5 6 increased insulin sensitivity 9.4976634160805e-11 4.97377636789479e-09 0.935488686528332 0.692307692307692 5.6 5 6 abnormal locomotor activation 2.35381959703001e-07 6.13102224880852e-06 0.935488686528332 0.692307692307692 5.6 5 6 increased grip strength 2.35381959703001e-07 6.13102224880852e-06 0.935488686528332 0.692307692307692 5.6 5 6 kinked neural tube 9.01202457697913e-05 0.00116454083819406 0.935488686528332 0.692307692307692 5.6 5 6 failure of heart looping 0.000682544742662792 0.00660634259678481 0.935488686528332 0.692307692307692 5.6 5 6 decreased B-1 B cell number 0.000682544742662792 0.00660634259678481 0.935488686528332 0.692307692307692 5.6 5 6 increased susceptibility to otitis media 0.00542826941970884 0.0355805538380125 0.935488686528332 0.692307692307692 5.6 5 6 abnormal erythrocyte osmotic lysis 0.00542826941970884 0.0355805538380125 0.935488686528332 0.692307692307692 5.6 5 6 absent teeth 0.0483878448987783 0.181135837751258 0.935488686528332 0.692307692307692 5.6 5 6 absent common myeloid progenitor cells 0.0483878448987783 0.181135837751258 0.935488686528332 0.692307692307692 5.6 5 6 increased foot pad pigmentation 0.0483878448987783 0.181135837751258 0.935488686528332 0.692307692307692 5.6 5 6 tight skin 0.0483878448987783 0.181135837751258 0.935488686528332 0.692307692307692 5.6 5 6 lymphoid hypoplasia 0.0483878448987783 0.181135837751258 0.935488686528332 0.692307692307692 5.6 5 6 abnormal pulmonary alveolus epithelial cell morphology 0.0483878448987783 0.181135837751258 0.935488686528332 0.692307692307692 5.6 5 6 increased synaptic depression 0.0483878448987783 0.181135837751258 0.935488686528332 0.692307692307692 5.6 5 6 abnormal telomere length 0.0483878448987783 0.181135837751258 0.935488686528332 0.692307692307692 5.6 5 6 abnormal retinal inner plexiform layer morphology 0.0483878448987783 0.181135837751258 0.935488686528332 0.692307692307692 5.6 5 6 abnormal exocrine pancreas morphology 0.0483878448987783 0.181135837751258 0.935488686528332 0.692307692307692 5.6 5 6 postnatal lethality, incomplete penetrance 2.77247556975607e-38 1.25391508723059e-35 0.934939690820275 0.691901408450704 5.6 5 6 abnormal reproductive system morphology 0.000465282389391439 0.00489382640004738 0.933013848733283 0.69047619047619 5.6 5 6 corneal opacity 5.81725322711202e-06 0.000109210697376914 0.932560709418697 0.690140845070423 5.6 5 6 cochlear ganglion degeneration 4.25221321279256e-05 0.000614963974815203 0.931904438687227 0.689655172413793 5.6 5 6 short sternum 0.00364893335482672 0.025496409326212 0.931904438687227 0.689655172413793 5.6 5 6 failure of primitive streak formation 0.00246107120146013 0.0189287452437854 0.928992237316329 0.6875 5.6 5 6 abnormal depression-related behavior 0.00246107120146013 0.0189287452437854 0.928992237316329 0.6875 5.6 5 6 abnormal spongiotrophoblast layer morphology 0.00246107120146013 0.0189287452437854 0.928992237316329 0.6875 5.6 5 6 abnormal tympanic ring morphology 0.0313339229137025 0.133609798276495 0.928992237316329 0.6875 5.6 5 6 absent mandible 0.0313339229137025 0.133609798276495 0.928992237316329 0.6875 5.6 5 6 failure of tooth eruption 0.0313339229137025 0.133609798276495 0.928992237316329 0.6875 5.6 5 6 abnormal olfaction 0.0313339229137025 0.133609798276495 0.928992237316329 0.6875 5.6 5 6 small pancreas 0.0313339229137025 0.133609798276495 0.928992237316329 0.6875 5.6 5 6 abnormal Langerhans cell physiology 0.0313339229137025 0.133609798276495 0.928992237316329 0.6875 5.6 5 6 abnormal thoracic cage shape 0.0313339229137025 0.133609798276495 0.928992237316329 0.6875 5.6 5 6 decreased adipocyte glucose uptake 0.0313339229137025 0.133609798276495 0.928992237316329 0.6875 5.6 5 6 rib fusion 1.38475876558966e-05 0.000233502726512047 0.927731732245344 0.686567164179104 5.6 5 6 increased lung adenocarcinoma incidence 0.000148564762704245 0.00181103070179243 0.927336279674054 0.686274509803922 5.6 5 6 failure of chorioallantoic fusion 0.000148564762704245 0.00181103070179243 0.927336279674054 0.686274509803922 5.6 5 6 abnormal action potential 9.53753646594062e-06 0.000167986564341044 0.926579270466157 0.685714285714286 5.6 5 6 thick pulmonary interalveolar septum 0.00166460043918906 0.0138716703265755 0.926579270466157 0.685714285714286 5.6 5 6 increased red blood cell distribution width 0.00166460043918906 0.0138716703265755 0.926579270466157 0.685714285714286 5.6 5 6 increased cell proliferation 0.000101768149323484 0.00130488799712457 0.925864317325365 0.685185185185185 5.6 5 6 increased grooming behavior 0.00112861571205231 0.010008668747701 0.924547298381801 0.684210526315789 5.6 5 6 impaired branching involved in ureteric bud morphogenesis 0.00112861571205231 0.010008668747701 0.924547298381801 0.684210526315789 5.6 5 6 shiny skin 0.0205310621539151 0.0961789399394798 0.924547298381801 0.684210526315789 5.6 5 6 abnormal stationary movement 0.0205310621539151 0.0961789399394798 0.924547298381801 0.684210526315789 5.6 5 6 decreased grooming behavior 0.0205310621539151 0.0961789399394798 0.924547298381801 0.684210526315789 5.6 5 6 decreased germ cell number 0.0205310621539151 0.0961789399394798 0.924547298381801 0.684210526315789 5.6 5 6 abnormal nasal septum morphology 0.0205310621539151 0.0961789399394798 0.924547298381801 0.684210526315789 5.6 5 6 decreased eye pigmentation 0.0205310621539151 0.0961789399394798 0.924547298381801 0.684210526315789 5.6 5 6 Leydig cell hypoplasia 0.0205310621539151 0.0961789399394798 0.924547298381801 0.684210526315789 5.6 5 6 shortened RR interval 0.0205310621539151 0.0961789399394798 0.924547298381801 0.684210526315789 5.6 5 6 increased hepatocellular carcinoma incidence 6.97774352545767e-05 0.000928189145431869 0.924547298381801 0.684210526315789 5.6 5 6 ventricular septal defect 9.71238434682173e-10 4.1654407004688e-08 0.924024364389504 0.683823529411765 5.6 5 6 abnormal somite development 3.12485622102136e-06 6.37137692605789e-05 0.923647057584935 0.683544303797468 5.6 5 6 reduced fertility 6.7391050184764e-10 2.99348638097501e-08 0.923524003087522 0.683453237410072 5.6 5 6 abnormal kidney development 4.78838256873919e-05 0.000680634379413643 0.923361981332594 0.683333333333333 5.6 5 6 decreased body size 6.03254085064047e-50 4.28741296170519e-47 0.922853988311505 0.682957393483709 5.6 5 6 premature death 7.88909583338897e-54 8.00105012168913e-51 0.922812688065888 0.682926829268293 5.6 5 6 scaly skin 0.000766815172292102 0.00725267201930268 0.922812688065888 0.682926829268293 5.6 5 6 abnormal circadian rhythm 0.000521949695359248 0.00531022440575104 0.921314615520327 0.681818181818182 5.6 5 6 abnormal astrocyte morphology 0.000521949695359248 0.00531022440575104 0.921314615520327 0.681818181818182 5.6 5 6 abnormal abdominal fat pad morphology 0.0135690037713283 0.0707581731933409 0.921314615520327 0.681818181818182 5.6 5 6 intracerebral hemorrhage 0.0135690037713283 0.0707581731933409 0.921314615520327 0.681818181818182 5.6 5 6 increased skin papilloma incidence 0.0135690037713283 0.0707581731933409 0.921314615520327 0.681818181818182 5.6 5 6 increased coping response 0.0135690037713283 0.0707581731933409 0.921314615520327 0.681818181818182 5.6 5 6 aphakia 0.0135690037713283 0.0707581731933409 0.921314615520327 0.681818181818182 5.6 5 6 abnormal vascular branching morphogenesis 0.0135690037713283 0.0707581731933409 0.921314615520327 0.681818181818182 5.6 5 6 prolonged PR interval 0.0135690037713283 0.0707581731933409 0.921314615520327 0.681818181818182 5.6 5 6 abnormal limb posture 0.0135690037713283 0.0707581731933409 0.921314615520327 0.681818181818182 5.6 5 6 decreased spleen weight 1.55429111178432e-05 0.000257753276037566 0.920424456471515 0.681159420289855 5.6 5 6 neuron degeneration 0.000355848415297299 0.00387384215777694 0.920007786278454 0.680851063829787 5.6 5 6 increased respiratory quotient 0.000355848415297299 0.00387384215777694 0.920007786278454 0.680851063829787 5.6 5 6 kyphosis 2.52541581461513e-10 1.20807150747214e-08 0.918857776545606 0.68 5.6 5 6 abnormal neurocranium morphology 7.36404504076278e-06 0.000136193769805929 0.918857776545606 0.68 5.6 5 6 abnormal cochlear outer hair cell morphology 0.00902701794790967 0.0536552142065121 0.918857776545606 0.68 5.6 5 6 abnormal energy expenditure 0.00902701794790967 0.0536552142065121 0.918857776545606 0.68 5.6 5 6 postnatal growth retardation 1.35428957376562e-37 5.61465885790329e-35 0.91850450558192 0.679738562091503 5.6 5 6 abnormal cornea morphology 5.07287466928163e-06 9.89707901163768e-05 0.918164821962992 0.67948717948718 5.6 5 6 abnormal jaw morphology 0.00603672991753479 0.0372152804705521 0.916927403065468 0.678571428571429 5.6 5 6 failure of blastocyst to hatch from the zona pellucida 0.00603672991753479 0.0372152804705521 0.916927403065468 0.678571428571429 5.6 5 6 abnormal hormone level 0.00603672991753479 0.0372152804705521 0.916927403065468 0.678571428571429 5.6 5 6 increased triglyceride level 0.00603672991753479 0.0372152804705521 0.916927403065468 0.678571428571429 5.6 5 6 abnormal testis morphology 3.70976917909478e-08 1.09857748011884e-06 0.916507756656742 0.678260869565217 5.6 5 6 oxidative stress 1.14747538242168e-06 2.56989491207913e-05 0.91585497335428 0.677777777777778 5.6 5 6 cataract 1.77761832680954e-08 5.6328988381385e-07 0.915730890577779 0.677685950413223 5.6 5 6 abnormal cranial ganglia morphology 0.00405408942185946 0.027960854534555 0.915370650258905 0.67741935483871 5.6 5 6 abnormal eyelid morphology 0.00405408942185946 0.027960854534555 0.915370650258905 0.67741935483871 5.6 5 6 increased lung adenoma incidence 0.00405408942185946 0.027960854534555 0.915370650258905 0.67741935483871 5.6 5 6 decreased thymus weight 0.00405408942185946 0.027960854534555 0.915370650258905 0.67741935483871 5.6 5 6 abnormal mitochondrial ATP synthesis coupled electron transport 0.00405408942185946 0.027960854534555 0.915370650258905 0.67741935483871 5.6 5 6 enlarged heart 8.21352858763342e-15 7.58596240134768e-13 0.914431230461841 0.676724137931034 5.6 5 6 decreased mean corpuscular hemoglobin 2.51721599025431e-05 0.000397560303222704 0.914088618535854 0.676470588235294 5.6 5 6 impaired skeletal muscle contractility 0.00184667624510474 0.0150418228242712 0.913014483848972 0.675675675675676 5.6 5 6 respiratory failure 4.52905251197453e-10 2.02991317541201e-08 0.912772625707555 0.675496688741722 5.6 5 6 neonatal lethality, complete penetrance 1.97634235296924e-27 4.99768877123296e-25 0.912694127889727 0.675438596491228 5.6 5 6 edema 3.49046020331576e-11 1.92944883461066e-09 0.911315852251114 0.674418604651163 5.6 5 6 delayed endochondral bone ossification 0.00084974069236378 0.00799141766447979 0.911315852251114 0.674418604651163 5.6 5 6 abnormal muscle physiology 1.84626829096904e-06 4.01099770636288e-05 0.910962765907739 0.674157303370786 5.6 5 6 abnormal sleep pattern 0.000578128132014914 0.00574089312729381 0.910632706934584 0.673913043478261 5.6 5 6 abnormal myelin sheath morphology 0.000578128132014914 0.00574089312729381 0.910632706934584 0.673913043478261 5.6 5 6 decreased circulating creatinine level 0.000393987091791173 0.00422432280530406 0.910033212064976 0.673469387755102 5.6 5 6 abnormal spermiogenesis 0.000125722531146122 0.0015690708727025 0.908606827720046 0.672413793103448 5.6 5 6 decreased circulating LDL cholesterol level 5.90321811237017e-05 0.000820349444386637 0.907878777377322 0.671875 5.6 5 6 abnormal cranium morphology 7.25625851204798e-09 2.61593377517672e-07 0.907563651109575 0.671641791044776 5.6 5 6 decreased percent body fat/body weight 1.91141145154744e-05 0.000313837358793681 0.907011100941472 0.671232876712329 5.6 5 6 abnormal nervous system morphology 9.04383535227366e-06 0.00016068957456272 0.906542482444473 0.670886075949367 5.6 5 6 extramedullary hematopoiesis 3.19258470660493e-07 8.06249183520789e-06 0.905090207196698 0.669811320754717 5.6 5 6 abnormal vertebrae morphology 2.20578335915588e-07 5.80622868349233e-06 0.904973255367367 0.669724770642202 5.6 5 6 impaired glucose tolerance 6.5922455059957e-15 6.30700411390935e-13 0.904473380612966 0.669354838709677 5.6 5 6 abnormal tail morphology 6.47452498801555e-05 0.000872920374400471 0.900840957397653 0.666666666666667 5.6 5 6 heart right ventricle hypertrophy 0.0029881064260768 0.0217019408317257 0.900840957397653 0.666666666666667 5.6 5 6 abnormal limb bone morphology 0.0029881064260768 0.0217019408317257 0.900840957397653 0.666666666666667 5.6 5 6 abnormal tooth development 0.00443101753377073 0.0301976879869992 0.900840957397653 0.666666666666667 5.6 5 6 cardiovascular system phenotype 0.00443101753377073 0.0301976879869992 0.900840957397653 0.666666666666667 5.6 5 6 lowered ear position 0.0339854594094287 0.138022580050537 0.900840957397653 0.666666666666667 5.6 5 6 abnormal thymus cortex morphology 0.0339854594094287 0.138022580050537 0.900840957397653 0.666666666666667 5.6 5 6 abnormal white adipose tissue morphology 0.0339854594094287 0.138022580050537 0.900840957397653 0.666666666666667 5.6 5 6 acidosis 0.0339854594094287 0.138022580050537 0.900840957397653 0.666666666666667 5.6 5 6 absent allantois 0.0339854594094287 0.138022580050537 0.900840957397653 0.666666666666667 5.6 5 6 absent ureter 0.0339854594094287 0.138022580050537 0.900840957397653 0.666666666666667 5.6 5 6 atrioventricular block 0.0339854594094287 0.138022580050537 0.900840957397653 0.666666666666667 5.6 5 6 distorted hair follicle pattern 0.130248872089966 0.346257483157758 0.900840957397653 0.666666666666667 5.6 5 6 abnormal head movements 0.130248872089966 0.346257483157758 0.900840957397653 0.666666666666667 5.6 5 6 abnormal urinary bladder urothelium morphology 0.130248872089966 0.346257483157758 0.900840957397653 0.666666666666667 5.6 5 6 thick tail 0.130248872089966 0.346257483157758 0.900840957397653 0.666666666666667 5.6 5 6 abnormal geniculate ganglion morphology 0.130248872089966 0.346257483157758 0.900840957397653 0.666666666666667 5.6 5 6 decreased level of surface class I molecules 0.130248872089966 0.346257483157758 0.900840957397653 0.666666666666667 5.6 5 6 abnormal lung volume 0.130248872089966 0.346257483157758 0.900840957397653 0.666666666666667 5.6 5 6 polycythemia 0.130248872089966 0.346257483157758 0.900840957397653 0.666666666666667 5.6 5 6 abnormal postural reflex 0.130248872089966 0.346257483157758 0.900840957397653 0.666666666666667 5.6 5 6 decreased circulating bicarbonate level 0.130248872089966 0.346257483157758 0.900840957397653 0.666666666666667 5.6 5 6 genetic imprinting 0.130248872089966 0.346257483157758 0.900840957397653 0.666666666666667 5.6 5 6 abnormal abdominal wall morphology 0.130248872089966 0.346257483157758 0.900840957397653 0.666666666666667 5.6 5 6 abnormal ovary physiology 0.130248872089966 0.346257483157758 0.900840957397653 0.666666666666667 5.6 5 6 abnormal thymus physiology 0.130248872089966 0.346257483157758 0.900840957397653 0.666666666666667 5.6 5 6 decreased muscle weight 0.130248872089966 0.346257483157758 0.900840957397653 0.666666666666667 5.6 5 6 decreased vestibular hair cell number 0.130248872089966 0.346257483157758 0.900840957397653 0.666666666666667 5.6 5 6 small scapula 0.130248872089966 0.346257483157758 0.900840957397653 0.666666666666667 5.6 5 6 short frontal bone 0.130248872089966 0.346257483157758 0.900840957397653 0.666666666666667 5.6 5 6 abnormal CNS synapse formation 0.130248872089966 0.346257483157758 0.900840957397653 0.666666666666667 5.6 5 6 decreased thyroid-stimulating hormone level 0.130248872089966 0.346257483157758 0.900840957397653 0.666666666666667 5.6 5 6 abnormal posterior eye segment morphology 0.130248872089966 0.346257483157758 0.900840957397653 0.666666666666667 5.6 5 6 abnormal intervertebral disk development 0.130248872089966 0.346257483157758 0.900840957397653 0.666666666666667 5.6 5 6 decreased susceptibility to atherosclerosis 0.130248872089966 0.346257483157758 0.900840957397653 0.666666666666667 5.6 5 6 increased tidal volume 0.130248872089966 0.346257483157758 0.900840957397653 0.666666666666667 5.6 5 6 abnormal retinal development 0.130248872089966 0.346257483157758 0.900840957397653 0.666666666666667 5.6 5 6 eye opacity 0.130248872089966 0.346257483157758 0.900840957397653 0.666666666666667 5.6 5 6 abnormal telomere morphology 0.130248872089966 0.346257483157758 0.900840957397653 0.666666666666667 5.6 5 6 abnormal oxidative phosphorylation 0.130248872089966 0.346257483157758 0.900840957397653 0.666666666666667 5.6 5 6 abnormal coronary sinus connection 0.130248872089966 0.346257483157758 0.900840957397653 0.666666666666667 5.6 5 6 cerebellum atrophy 0.130248872089966 0.346257483157758 0.900840957397653 0.666666666666667 5.6 5 6 increased endoplasmic reticulum stress 0.130248872089966 0.346257483157758 0.900840957397653 0.666666666666667 5.6 5 6 thymus atrophy 0.000633336775457626 0.00616604786282131 0.900840957397653 0.666666666666667 5.6 5 6 increased circulating corticosterone level 0.000930595804958224 0.00862144158224798 0.900840957397653 0.666666666666667 5.6 5 6 skin edema 0.00136988073809343 0.0117032772946369 0.900840957397653 0.666666666666667 5.6 5 6 abnormal iris morphology 0.00202075765083133 0.0161368688810367 0.900840957397653 0.666666666666667 5.6 5 6 decreased trabecular bone volume 0.00202075765083133 0.0161368688810367 0.900840957397653 0.666666666666667 5.6 5 6 disorganized myocardium 0.00659263319105552 0.0404917902783966 0.900840957397653 0.666666666666667 5.6 5 6 rectal prolapse 0.00984806701851002 0.0574374365968199 0.900840957397653 0.666666666666667 5.6 5 6 decreased body height 0.0147830479175937 0.0746656481117042 0.900840957397653 0.666666666666667 5.6 5 6 abnormal body weight 0.0147830479175937 0.0746656481117042 0.900840957397653 0.666666666666667 5.6 5 6 abnormal startle reflex 0.0147830479175937 0.0746656481117042 0.900840957397653 0.666666666666667 5.6 5 6 abnormal primitive streak formation 0.0147830479175937 0.0746656481117042 0.900840957397653 0.666666666666667 5.6 5 6 prolonged QT interval 0.0147830479175937 0.0746656481117042 0.900840957397653 0.666666666666667 5.6 5 6 abnormal anxiety-related response 0.0223267804813723 0.104198623728731 0.900840957397653 0.666666666666667 5.6 5 6 liver degeneration 0.0223267804813723 0.104198623728731 0.900840957397653 0.666666666666667 5.6 5 6 abnormal erythrocyte physiology 0.0223267804813723 0.104198623728731 0.900840957397653 0.666666666666667 5.6 5 6 decreased vocalization 0.0223267804813723 0.104198623728731 0.900840957397653 0.666666666666667 5.6 5 6 absent incisors 0.0522762220493843 0.192309931484681 0.900840957397653 0.666666666666667 5.6 5 6 macrocytosis 0.0522762220493843 0.192309931484681 0.900840957397653 0.666666666666667 5.6 5 6 abnormal enteric neuron morphology 0.0522762220493843 0.192309931484681 0.900840957397653 0.666666666666667 5.6 5 6 abnormal prostate gland morphology 0.0522762220493843 0.192309931484681 0.900840957397653 0.666666666666667 5.6 5 6 no suckling reflex 0.0522762220493843 0.192309931484681 0.900840957397653 0.666666666666667 5.6 5 6 abnormal cricoid cartilage morphology 0.0522762220493843 0.192309931484681 0.900840957397653 0.666666666666667 5.6 5 6 abnormal lymph node B cell domain morphology 0.0522762220493843 0.192309931484681 0.900840957397653 0.666666666666667 5.6 5 6 abnormal pericyte morphology 0.0522762220493843 0.192309931484681 0.900840957397653 0.666666666666667 5.6 5 6 decreased aggression towards males 0.0522762220493843 0.192309931484681 0.900840957397653 0.666666666666667 5.6 5 6 abnormal olfactory nerve morphology 0.0522762220493843 0.192309931484681 0.900840957397653 0.666666666666667 5.6 5 6 abnormal neurotransmitter secretion 0.0522762220493843 0.192309931484681 0.900840957397653 0.666666666666667 5.6 5 6 abnormal dendritic cell morphology 0.0522762220493843 0.192309931484681 0.900840957397653 0.666666666666667 5.6 5 6 ostium primum atrial septal defect 0.0522762220493843 0.192309931484681 0.900840957397653 0.666666666666667 5.6 5 6 abnormal coronary vessel morphology 0.0522762220493843 0.192309931484681 0.900840957397653 0.666666666666667 5.6 5 6 herniated liver 0.0522762220493843 0.192309931484681 0.900840957397653 0.666666666666667 5.6 5 6 abnormal branching involved in lung morphogenesis 0.0522762220493843 0.192309931484681 0.900840957397653 0.666666666666667 5.6 5 6 abnormal supraoccipital bone morphology 0.0816019893921679 0.245744489846268 0.900840957397653 0.666666666666667 5.6 5 6 abnormal mineral level 0.0816019893921679 0.245744489846268 0.900840957397653 0.666666666666667 5.6 5 6 mesocardia 0.0816019893921679 0.245744489846268 0.900840957397653 0.666666666666667 5.6 5 6 abnormal enteric nervous system morphology 0.0816019893921679 0.245744489846268 0.900840957397653 0.666666666666667 5.6 5 6 abnormal pilomotor reflex 0.0816019893921679 0.245744489846268 0.900840957397653 0.666666666666667 5.6 5 6 abnormal tracheal ciliated epithelium morphology 0.0816019893921679 0.245744489846268 0.900840957397653 0.666666666666667 5.6 5 6 abnormal gastrocnemius morphology 0.0816019893921679 0.245744489846268 0.900840957397653 0.666666666666667 5.6 5 6 abnormal alisphenoid bone morphology 0.0816019893921679 0.245744489846268 0.900840957397653 0.666666666666667 5.6 5 6 loss of dopaminergic neurons 0.0816019893921679 0.245744489846268 0.900840957397653 0.666666666666667 5.6 5 6 dilated bile duct 0.0816019893921679 0.245744489846268 0.900840957397653 0.666666666666667 5.6 5 6 abnormal vascular endothelial cell development 0.0816019893921679 0.245744489846268 0.900840957397653 0.666666666666667 5.6 5 6 delayed somite formation 0.0816019893921679 0.245744489846268 0.900840957397653 0.666666666666667 5.6 5 6 abnormal nucleotide metabolism 0.0816019893921679 0.245744489846268 0.900840957397653 0.666666666666667 5.6 5 6 abnormal cochlear outer hair cell physiology 0.0816019893921679 0.245744489846268 0.900840957397653 0.666666666666667 5.6 5 6 abnormal fatty acid level 0.0816019893921679 0.245744489846268 0.900840957397653 0.666666666666667 5.6 5 6 abnormal somatic nervous system physiology 0.0816019893921679 0.245744489846268 0.900840957397653 0.666666666666667 5.6 5 6 abnormal respiratory motile cilium morphology 0.0816019893921679 0.245744489846268 0.900840957397653 0.666666666666667 5.6 5 6 decreased lymphocyte cell number 4.18641097461349e-08 1.21797629232176e-06 0.897322047407818 0.6640625 5.6 5 6 decreased cardiac muscle contractility 8.02865537735846e-07 1.88408304256407e-05 0.896509991256318 0.663461538461538 5.6 5 6 decreased birth weight 2.44223571338785e-06 5.17026496770406e-05 0.896099689200823 0.663157894736842 5.6 5 6 abnormal kidney morphology 1.85345515115642e-10 9.22093937700318e-09 0.895693294783952 0.662857142857143 5.6 5 6 increased oxygen consumption 7.45566246451603e-06 0.000136870556313532 0.895603509970922 0.662790697674419 5.6 5 6 increased circulating creatinine level 7.45566246451603e-06 0.000136870556313532 0.895603509970922 0.662790697674419 5.6 5 6 abnormal retinal pigment epithelium morphology 1.57277415645054e-05 0.000259091106898723 0.895210701413917 0.6625 5.6 5 6 abnormal intestine morphology 3.32544573461258e-05 0.000499821526576966 0.894754194171993 0.662162162162162 5.6 5 6 atelectasis 4.84030310912262e-05 0.000682167364529321 0.894497006993444 0.661971830985915 5.6 5 6 abnormal skeletal muscle fiber morphology 4.84030310912262e-05 0.000682167364529321 0.894497006993444 0.661971830985915 5.6 5 6 increased heart weight 1.51323542268192e-08 4.88853651158608e-07 0.894360087200547 0.661870503597122 5.6 5 6 abnormal coat/ hair morphology 0.000468794819829813 0.00491000890242804 0.892342457799562 0.660377358490566 5.6 5 6 increased circulating bilirubin level 0.000468794819829813 0.00491000890242804 0.892342457799562 0.660377358490566 5.6 5 6 male infertility 1.07219418947214e-26 2.3192026489669e-24 0.891886275912587 0.660039761431412 5.6 5 6 decreased circulating alkaline phosphatase level 0.000687172634238842 0.00662535630879503 0.891832547823676 0.66 5.6 5 6 increased circulating chloride level 0.000687172634238842 0.00662535630879503 0.891832547823676 0.66 5.6 5 6 increased thermal nociceptive threshold 5.57829388366741e-06 0.000105121257845626 0.890941606217459 0.659340659340659 5.6 5 6 abnormal liver morphology 2.19276316685963e-10 1.06950948579673e-08 0.890775695303824 0.659217877094972 5.6 5 6 insulin resistance 4.9543411410568e-08 1.40044586231577e-06 0.890604128336316 0.659090909090909 5.6 5 6 abnormal suckling behavior 8.09248413298293e-06 0.000145869958556486 0.890604128336316 0.659090909090909 5.6 5 6 hyperglycemia 8.09248413298293e-06 0.000145869958556486 0.890604128336316 0.659090909090909 5.6 5 6 teratozoospermia 8.09248413298293e-06 0.000145869958556486 0.890604128336316 0.659090909090909 5.6 5 6 hypertension 0.00148346995323919 0.0125089203684152 0.890604128336316 0.659090909090909 5.6 5 6 embryonic lethality, incomplete penetrance 0.00148346995323919 0.0125089203684152 0.890604128336316 0.659090909090909 5.6 5 6 cardiac fibrosis 1.17452787100378e-05 0.00020011219720013 0.890242828487092 0.658823529411765 5.6 5 6 liver fibrosis 0.00218572153754773 0.017287702145151 0.889855092063535 0.658536585365854 5.6 5 6 short ulna 0.00218572153754773 0.017287702145151 0.889855092063535 0.658536585365854 5.6 5 6 palatal shelves fail to meet at midline 0.00218572153754773 0.017287702145151 0.889855092063535 0.658536585365854 5.6 5 6 abnormal myocardium layer morphology 2.47795619628037e-05 0.000392606117085823 0.889437907304012 0.658227848101266 5.6 5 6 decreased bone mineral density 1.45505026694098e-14 1.29265626393417e-12 0.888987786905578 0.657894736842105 5.6 5 6 abnormal axial skeleton morphology 3.60229308154585e-05 0.000538180422843562 0.888987786905578 0.657894736842105 5.6 5 6 abnormal frontal bone morphology 0.00322756188559021 0.0232039311861435 0.888987786905578 0.657894736842105 5.6 5 6 incomplete somite formation 0.00322756188559021 0.0232039311861435 0.888987786905578 0.657894736842105 5.6 5 6 hyporesponsive to tactile stimuli 0.00322756188559021 0.0232039311861435 0.888987786905578 0.657894736842105 5.6 5 6 short snout 9.4592721107654e-07 2.17869809032675e-05 0.888329277433796 0.657407407407407 5.6 5 6 spleen hypoplasia 1.36913549548427e-06 3.02731070668188e-05 0.887971800863401 0.657142857142857 5.6 5 6 impaired behavioral response to xenobiotic 0.0047782619726593 0.0318718842422328 0.887971800863401 0.657142857142857 5.6 5 6 kidney cortex cysts 0.00709530602443998 0.0427868454201078 0.886765317438314 0.65625 5.6 5 6 increased circulating follicle stimulating hormone level 0.00709530602443998 0.0427868454201078 0.886765317438314 0.65625 5.6 5 6 abnormal embryonic hematopoiesis 0.00709530602443998 0.0427868454201078 0.886765317438314 0.65625 5.6 5 6 decreased circulating cholesterol level 2.56862506491206e-10 1.21703901885119e-08 0.88607307285015 0.655737704918033 5.6 5 6 increased blood urea nitrogen level 1.92429114717459e-08 6.05908130202127e-07 0.885309216752866 0.655172413793103 5.6 5 6 lordosis 0.0105735433866801 0.0608466329232416 0.885309216752866 0.655172413793103 5.6 5 6 abnormal spinal nerve morphology 0.0105735433866801 0.0608466329232416 0.885309216752866 0.655172413793103 5.6 5 6 abnormal outer ear morphology 0.0105735433866801 0.0608466329232416 0.885309216752866 0.655172413793103 5.6 5 6 abnormal platelet physiology 0.000504959143072079 0.00519043747269338 0.884462030899514 0.654545454545455 5.6 5 6 absent gastric milk in neonates 3.88057102603057e-05 0.000577941618895243 0.883517092832313 0.653846153846154 5.6 5 6 abnormal skin condition 0.000739304253360277 0.00703257870070245 0.883517092832313 0.653846153846154 5.6 5 6 heart inflammation 0.0158246540567335 0.0789736842367333 0.883517092832313 0.653846153846154 5.6 5 6 increased leukemia incidence 0.0158246540567335 0.0789736842367333 0.883517092832313 0.653846153846154 5.6 5 6 pulmonary edema 0.0158246540567335 0.0789736842367333 0.883517092832313 0.653846153846154 5.6 5 6 abnormal nerve conduction 0.0158246540567335 0.0789736842367333 0.883517092832313 0.653846153846154 5.6 5 6 delayed bone ossification 5.64042920568582e-05 0.000788234137592331 0.8828241382497 0.653333333333333 5.6 5 6 abnormal limb morphology 5.64042920568582e-05 0.000788234137592331 0.8828241382497 0.653333333333333 5.6 5 6 cardiac hypertrophy 4.47789744784114e-06 8.8755138657409e-05 0.882456448063007 0.653061224489796 5.6 5 6 decreased hemoglobin content 4.31322786443622e-08 1.24757608288199e-06 0.881674128516852 0.652482269503546 5.6 5 6 abnormal postnatal growth 0.0238086690453853 0.108802794286739 0.881257458323791 0.652173913043478 5.6 5 6 abnormal Wolffian duct morphology 0.0238086690453853 0.108802794286739 0.881257458323791 0.652173913043478 5.6 5 6 abnormal chondrocyte physiology 0.0238086690453853 0.108802794286739 0.881257458323791 0.652173913043478 5.6 5 6 abnormal vertebral artery topology 0.0238086690453853 0.108802794286739 0.881257458323791 0.652173913043478 5.6 5 6 impaired swimming 0.000173891866325327 0.00207959623790506 0.880367299274979 0.651515151515151 5.6 5 6 increased circulating aspartate transaminase level 0.000253471270197336 0.00289224671842144 0.879392363173899 0.650793650793651 5.6 5 6 decreased hematocrit 3.2096347800421e-08 9.61923676548761e-07 0.879245454994284 0.650684931506849 5.6 5 6 increased or absent threshold for auditory brainstem response 8.23400944065878e-15 7.58596240134768e-13 0.879021280228851 0.650519031141868 5.6 5 6 head bobbing 0.00344971368771248 0.0244477572597857 0.878319933462711 0.65 5.6 5 6 perinatal lethality 0.00344971368771248 0.0244477572597857 0.878319933462711 0.65 5.6 5 6 small gonad 0.0360585369295454 0.143169370490414 0.878319933462711 0.65 5.6 5 6 increased urine glucose level 0.0360585369295454 0.143169370490414 0.878319933462711 0.65 5.6 5 6 abnormal optic stalk morphology 0.0360585369295454 0.143169370490414 0.878319933462711 0.65 5.6 5 6 dilated vasculature 0.0360585369295454 0.143169370490414 0.878319933462711 0.65 5.6 5 6 abnormal heart electrocardiography waveform feature 0.0360585369295454 0.143169370490414 0.878319933462711 0.65 5.6 5 6 decreased muscle cell glucose uptake 0.0360585369295454 0.143169370490414 0.878319933462711 0.65 5.6 5 6 abnormal incisor morphology 0.000369795051478942 0.00400812719195586 0.878319933462711 0.65 5.6 5 6 muscular ventricular septal defect 0.000369795051478942 0.00400812719195586 0.878319933462711 0.65 5.6 5 6 abnormal enzyme/coenzyme activity 1.14817860371034e-08 3.90619129181027e-07 0.877889595425738 0.64968152866242 5.6 5 6 abnormal craniofacial bone morphology 0.000540025794022996 0.00544955035550589 0.877134616413504 0.649122807017544 5.6 5 6 decreased circulating glucose level 3.77633493319459e-14 3.03020424074889e-12 0.876624802628899 0.648745519713262 5.6 5 6 decreased circulating HDL cholesterol level 2.89081350174117e-07 7.45170837884059e-06 0.876208587468811 0.6484375 5.6 5 6 thrombocytopenia 4.9532867223546e-08 1.40044586231577e-06 0.875990172365993 0.648275862068965 5.6 5 6 azoospermia 1.22805209062721e-08 4.1003752690405e-07 0.87534545860338 0.647798742138365 5.6 5 6 abnormal vision 0.00754562352898918 0.0454473087853767 0.874345635121251 0.647058823529412 5.6 5 6 abnormal bone marrow cavity morphology 0.055080222228575 0.195452286438773 0.874345635121251 0.647058823529412 5.6 5 6 abnormal urinary bladder morphology 0.055080222228575 0.195452286438773 0.874345635121251 0.647058823529412 5.6 5 6 increased incidence of corneal inflammation 0.055080222228575 0.195452286438773 0.874345635121251 0.647058823529412 5.6 5 6 abnormal heart rate 0.055080222228575 0.195452286438773 0.874345635121251 0.647058823529412 5.6 5 6 abnormal melanosome morphology 0.055080222228575 0.195452286438773 0.874345635121251 0.647058823529412 5.6 5 6 increased circulating magnesium level 0.055080222228575 0.195452286438773 0.874345635121251 0.647058823529412 5.6 5 6 increased hepatoma incidence 0.055080222228575 0.195452286438773 0.874345635121251 0.647058823529412 5.6 5 6 abnormal survival 0.055080222228575 0.195452286438773 0.874345635121251 0.647058823529412 5.6 5 6 microphthalmia 2.54787045239526e-08 7.8730779507245e-07 0.874345635121251 0.647058823529412 5.6 5 6 abnormal spermatogenesis 1.09279700077403e-09 4.60734328716169e-08 0.873913646171092 0.646739130434783 5.6 5 6 sparse hair 4.43641281926482e-05 0.000636056304779322 0.873376294062358 0.646341463414634 5.6 5 6 abnormal developmental patterning 4.43641281926482e-05 0.000636056304779322 0.873376294062358 0.646341463414634 5.6 5 6 retinal degeneration 1.07282392596948e-05 0.000185322883045074 0.872689677478976 0.645833333333333 5.6 5 6 oligodactyly 0.00169345435013338 0.0140885207222635 0.872689677478976 0.645833333333333 5.6 5 6 increased sensitivity to xenobiotic induced morbidity/mortality 2.61569747947171e-06 5.4221229001549e-05 0.872177836025909 0.645454545454546 5.6 5 6 decreased insulin secretion 2.24687076156622e-05 0.000360586517380386 0.870812925484398 0.644444444444444 5.6 5 6 abnormal autopod morphology 0.00248555434699846 0.0189287452437854 0.870812925484398 0.644444444444444 5.6 5 6 irregular heartbeat 0.00248555434699846 0.0189287452437854 0.870812925484398 0.644444444444444 5.6 5 6 abnormal cell migration 0.00248555434699846 0.0189287452437854 0.870812925484398 0.644444444444444 5.6 5 6 small placenta 0.00248555434699846 0.0189287452437854 0.870812925484398 0.644444444444444 5.6 5 6 abnormal metabolism 0.00248555434699846 0.0189287452437854 0.870812925484398 0.644444444444444 5.6 5 6 cardiomyopathy 0.00248555434699846 0.0189287452437854 0.870812925484398 0.644444444444444 5.6 5 6 lethality at weaning, complete penetrance 0.00248555434699846 0.0189287452437854 0.870812925484398 0.644444444444444 5.6 5 6 increased hemoglobin content 0.000573835493619085 0.00572110537225441 0.870303975790953 0.644067796610169 5.6 5 6 decreased bone marrow cell number 0.000135604074233208 0.0016698769042332 0.869990239678555 0.643835616438356 5.6 5 6 abnormal fertility/fecundity 0.000135604074233208 0.0016698769042332 0.869990239678555 0.643835616438356 5.6 5 6 abnormal retinal pigmentation 3.25314780344172e-05 0.000494936095477754 0.869777476108079 0.64367816091954 5.6 5 6 abnormal pulmonary alveolus morphology 7.88609411593033e-06 0.000143711788376386 0.869623696497734 0.643564356435644 5.6 5 6 reduced male fertility 2.75944314450978e-11 1.54249771280181e-09 0.869093258458528 0.643171806167401 5.6 5 6 polydactyly 1.13971501079008e-05 0.000195520075126919 0.868668066062022 0.642857142857143 5.6 5 6 abnormal coat/hair pigmentation 2.77931875017136e-06 5.71368214136467e-05 0.868668066062022 0.642857142857143 5.6 5 6 short mandible 0.000837444399064723 0.00789069296467235 0.868668066062022 0.642857142857143 5.6 5 6 abnormal eye development 0.000837444399064723 0.00789069296467235 0.868668066062022 0.642857142857143 5.6 5 6 abnormal ovulation 0.0167084738002654 0.0830416155407797 0.868668066062022 0.642857142857143 5.6 5 6 abnormal retinal inner nuclear layer morphology 0.0167084738002654 0.0830416155407797 0.868668066062022 0.642857142857143 5.6 5 6 abnormal renal tubule epithelium morphology 0.0167084738002654 0.0830416155407797 0.868668066062022 0.642857142857143 5.6 5 6 abnormal vasoconstriction 0.0851094014835491 0.254000763275739 0.868668066062022 0.642857142857143 5.6 5 6 translucent skin 0.0851094014835491 0.254000763275739 0.868668066062022 0.642857142857143 5.6 5 6 irregularly shaped pupil 0.0851094014835491 0.254000763275739 0.868668066062022 0.642857142857143 5.6 5 6 abnormal placing response 0.0851094014835491 0.254000763275739 0.868668066062022 0.642857142857143 5.6 5 6 decreased coping response 0.0851094014835491 0.254000763275739 0.868668066062022 0.642857142857143 5.6 5 6 abnormal sagittal suture morphology 0.0851094014835491 0.254000763275739 0.868668066062022 0.642857142857143 5.6 5 6 spina bifida occulta 0.0851094014835491 0.254000763275739 0.868668066062022 0.642857142857143 5.6 5 6 decreased compact bone area 0.0851094014835491 0.254000763275739 0.868668066062022 0.642857142857143 5.6 5 6 decreased response to antigen 0.0851094014835491 0.254000763275739 0.868668066062022 0.642857142857143 5.6 5 6 reduced female fertility 2.04035479859846e-11 1.16675461184222e-09 0.86783600852748 0.642241379310345 5.6 5 6 increased circulating cholesterol level 5.29129270578561e-09 2.02493701625257e-07 0.867571262948308 0.642045454545455 5.6 5 6 increased exploration in new environment 6.82656047477471e-05 0.000912960708656026 0.867476477494036 0.641975308641975 5.6 5 6 enlarged kidney 0.00122337376599372 0.0107531528018 0.866846959005288 0.641509433962264 5.6 5 6 abnormal pancreatic islet morphology 0.00122337376599372 0.0107531528018 0.866846959005288 0.641509433962264 5.6 5 6 increased circulating alanine transaminase level 9.89451588701353e-05 0.00127196941958378 0.866193228266974 0.641025641025641 5.6 5 6 abnormal heart looping 0.00538256944765959 0.0353742179684365 0.866193228266974 0.641025641025641 5.6 5 6 abnormal circulating hormone level 0.00538256944765959 0.0353742179684365 0.866193228266974 0.641025641025641 5.6 5 6 decreased oocyte number 0.00178913019601105 0.0147610658791957 0.864807319101747 0.64 5.6 5 6 ruffled hair 0.0250159900859209 0.113865096685687 0.864807319101747 0.64 5.6 5 6 abnormal thyroid gland morphology 0.0250159900859209 0.113865096685687 0.864807319101747 0.64 5.6 5 6 postnatal lethality, complete penetrance 1.18140895617227e-17 1.43353891633099e-15 0.864667292009923 0.639896373056995 5.6 5 6 abnormal lipid level 7.21164531245873e-05 0.000956744944786192 0.8628536881098 0.63855421686747 5.6 5 6 pulmonary hypoplasia 0.00261972729508868 0.0194524526762182 0.86250729963605 0.638297872340426 5.6 5 6 abnormal retina morphology 3.88784090002812e-10 1.77449619060916e-08 0.862233487794896 0.638095238095238 5.6 5 6 increased circulating insulin level 4.92420065851944e-08 1.40044586231577e-06 0.861429165511505 0.6375 5.6 5 6 obese 0.000151139990075907 0.00182505206463019 0.859893641152305 0.636363636363636 5.6 5 6 abnormal vascular development 0.000438595741237228 0.00466242267661369 0.859893641152305 0.636363636363636 5.6 5 6 belly spot 0.0117578108831111 0.0670815471828875 0.859893641152305 0.636363636363636 5.6 5 6 abnormal ovarian folliculogenesis 0.0117578108831111 0.0670815471828875 0.859893641152305 0.636363636363636 5.6 5 6 abnormal skeleton physiology 0.0117578108831111 0.0670815471828875 0.859893641152305 0.636363636363636 5.6 5 6 increased cardiomyocyte apoptosis 0.0117578108831111 0.0670815471828875 0.859893641152305 0.636363636363636 5.6 5 6 myeloid hyperplasia 0.0117578108831111 0.0670815471828875 0.859893641152305 0.636363636363636 5.6 5 6 abnormal amino acid level 0.0038411518463339 0.0268018659684588 0.859893641152305 0.636363636363636 5.6 5 6 increased body size 0.0376528897239493 0.148198675930892 0.859893641152305 0.636363636363636 5.6 5 6 intestinal inflammation 0.0376528897239493 0.148198675930892 0.859893641152305 0.636363636363636 5.6 5 6 abnormal basement membrane morphology 0.0376528897239493 0.148198675930892 0.859893641152305 0.636363636363636 5.6 5 6 abnormal blood-brain barrier function 0.0376528897239493 0.148198675930892 0.859893641152305 0.636363636363636 5.6 5 6 cleft upper lip 0.0376528897239493 0.148198675930892 0.859893641152305 0.636363636363636 5.6 5 6 abnormal sperm midpiece morphology 0.0376528897239493 0.148198675930892 0.859893641152305 0.636363636363636 5.6 5 6 pulmonary vascular congestion 0.0376528897239493 0.148198675930892 0.859893641152305 0.636363636363636 5.6 5 6 increased circulating creatine kinase level 0.0376528897239493 0.148198675930892 0.859893641152305 0.636363636363636 5.6 5 6 increased mammary gland tumor incidence 0.0376528897239493 0.148198675930892 0.859893641152305 0.636363636363636 5.6 5 6 premature suture closure 0.133672260434853 0.346257483157758 0.859893641152305 0.636363636363636 5.6 5 6 abnormal sphenoid bone morphology 0.133672260434853 0.346257483157758 0.859893641152305 0.636363636363636 5.6 5 6 delayed hepatic development 0.133672260434853 0.346257483157758 0.859893641152305 0.636363636363636 5.6 5 6 abnormal sebaceous gland morphology 0.133672260434853 0.346257483157758 0.859893641152305 0.636363636363636 5.6 5 6 impaired myelopoiesis 0.133672260434853 0.346257483157758 0.859893641152305 0.636363636363636 5.6 5 6 decreased post-tetanic potentiation 0.133672260434853 0.346257483157758 0.859893641152305 0.636363636363636 5.6 5 6 patent ductus arteriosus 0.133672260434853 0.346257483157758 0.859893641152305 0.636363636363636 5.6 5 6 abnormal frequency of paradoxical sleep 0.133672260434853 0.346257483157758 0.859893641152305 0.636363636363636 5.6 5 6 dilated renal glomerular capsule 0.133672260434853 0.346257483157758 0.859893641152305 0.636363636363636 5.6 5 6 abnormal coronal suture morphology 0.133672260434853 0.346257483157758 0.859893641152305 0.636363636363636 5.6 5 6 increased motor neuron number 0.133672260434853 0.346257483157758 0.859893641152305 0.636363636363636 5.6 5 6 increased circulating triiodothyronine level 0.133672260434853 0.346257483157758 0.859893641152305 0.636363636363636 5.6 5 6 abnormal platelet aggregation 0.133672260434853 0.346257483157758 0.859893641152305 0.636363636363636 5.6 5 6 abnormal superovulation 0.133672260434853 0.346257483157758 0.859893641152305 0.636363636363636 5.6 5 6 decreased palatine bone horizontal plate size 0.133672260434853 0.346257483157758 0.859893641152305 0.636363636363636 5.6 5 6 increased number of Howell-Jolly bodies 0.133672260434853 0.346257483157758 0.859893641152305 0.636363636363636 5.6 5 6 common atrioventricular valve 0.133672260434853 0.346257483157758 0.859893641152305 0.636363636363636 5.6 5 6 increased pancreatic beta cell proliferation 0.133672260434853 0.346257483157758 0.859893641152305 0.636363636363636 5.6 5 6 chylous ascites 0.133672260434853 0.346257483157758 0.859893641152305 0.636363636363636 5.6 5 6 hypolactation 0.133672260434853 0.346257483157758 0.859893641152305 0.636363636363636 5.6 5 6 decreased leukocyte cell number 5.89676219796142e-07 1.40365511650039e-05 0.858100328032071 0.635036496350365 5.6 5 6 abnormal skeleton morphology 4.71338152535344e-06 9.26840833542821e-05 0.857757259435156 0.634782608695652 5.6 5 6 increased circulating triglyceride level 3.00572024301048e-07 7.64730730901791e-06 0.857352083592249 0.63448275862069 5.6 5 6 decreased liver weight 0.000317173601006538 0.00352218452010609 0.856433304568191 0.633802816901408 5.6 5 6 increased erythrocyte cell number 0.000926268984588427 0.00859736604165564 0.85579890952777 0.633333333333333 5.6 5 6 emphysema 0.0174496609973043 0.0864661986669212 0.85579890952777 0.633333333333333 5.6 5 6 abnormal fat pad morphology 0.0174496609973043 0.0864661986669212 0.85579890952777 0.633333333333333 5.6 5 6 abnormal visceral yolk sac morphology 0.000158586230169557 0.00190571617172354 0.855228757023088 0.632911392405063 5.6 5 6 decreased food intake 0.000158586230169557 0.00190571617172354 0.855228757023088 0.632911392405063 5.6 5 6 increased sarcoma incidence 0.0027432813947641 0.0203395304604343 0.854879684061038 0.63265306122449 5.6 5 6 female infertility 8.65956752261839e-12 5.12873195536029e-10 0.853428275429355 0.631578947368421 5.6 5 6 abnormal triglyceride level 0.0570501404188808 0.200866559507383 0.853428275429355 0.631578947368421 5.6 5 6 flaky skin 0.0570501404188808 0.200866559507383 0.853428275429355 0.631578947368421 5.6 5 6 decreased chemically-elicited antinociception 0.0570501404188808 0.200866559507383 0.853428275429355 0.631578947368421 5.6 5 6 abnormal neurotransmitter level 0.0570501404188808 0.200866559507383 0.853428275429355 0.631578947368421 5.6 5 6 maternal imprinting 0.0570501404188808 0.200866559507383 0.853428275429355 0.631578947368421 5.6 5 6 abnormal optic vesicle formation 0.0570501404188808 0.200866559507383 0.853428275429355 0.631578947368421 5.6 5 6 abnormal sternebra morphology 0.0570501404188808 0.200866559507383 0.853428275429355 0.631578947368421 5.6 5 6 decreased susceptibility to weight gain 0.0570501404188808 0.200866559507383 0.853428275429355 0.631578947368421 5.6 5 6 thin interventricular septum 0.0570501404188808 0.200866559507383 0.853428275429355 0.631578947368421 5.6 5 6 thymus hypoplasia 9.31061408277088e-07 2.1544327935714e-05 0.851882209712998 0.630434782608696 5.6 5 6 abnormal allantois morphology 0.00401075246481459 0.0279460693451717 0.851882209712998 0.630434782608696 5.6 5 6 decreased heart rate 2.90874417318791e-05 0.000448018645870274 0.851294704740782 0.63 5.6 5 6 abnormal cochlea morphology 0.00196101918622162 0.01571025837593 0.850794237542227 0.62962962962963 5.6 5 6 decreased tumor growth/size 0.00196101918622162 0.01571025837593 0.850794237542227 0.62962962962963 5.6 5 6 abnormal fetal cardiomyocyte proliferation 0.0259848520217134 0.117302041662703 0.850794237542227 0.62962962962963 5.6 5 6 abnormal artery morphology 0.0122288507781628 0.0684706935924497 0.849364331260644 0.628571428571429 5.6 5 6 decreased glycogen level 0.0122288507781628 0.0684706935924497 0.849364331260644 0.628571428571429 5.6 5 6 increased spleen weight 1.06769529250755e-05 0.000185207487626223 0.849022672237611 0.628318584070796 5.6 5 6 abnormal vasculogenesis 0.00587064160993866 0.0370910758979354 0.848466483130347 0.627906976744186 5.6 5 6 abnormal heart morphology 4.1958738253697e-10 1.8976792982922e-08 0.848194407939348 0.627705627705628 5.6 5 6 cleft secondary palate 6.022920158264e-05 0.000821410984750499 0.84813217797545 0.627659574468085 5.6 5 6 abnormal glucose homeostasis 3.4932020736548e-08 1.04063953990614e-06 0.846394525906586 0.626373626373626 5.6 5 6 cochlear outer hair cell degeneration 0.000498921842355305 0.00516501782373863 0.844538397560299 0.625 5.6 5 6 polydipsia 0.0180629361375774 0.0890615533047051 0.844538397560299 0.625 5.6 5 6 increased fatty acid level 0.0180629361375774 0.0890615533047051 0.844538397560299 0.625 5.6 5 6 abnormal serotonin level 0.0180629361375774 0.0890615533047051 0.844538397560299 0.625 5.6 5 6 abnormal hair follicle orientation 0.0871800539421874 0.258013544534433 0.844538397560299 0.625 5.6 5 6 abnormal mouth morphology 0.0871800539421874 0.258013544534433 0.844538397560299 0.625 5.6 5 6 reduced male mating frequency 0.0871800539421874 0.258013544534433 0.844538397560299 0.625 5.6 5 6 disorganized yolk sac vascular plexus 0.0871800539421874 0.258013544534433 0.844538397560299 0.625 5.6 5 6 increased thymus weight 0.0871800539421874 0.258013544534433 0.844538397560299 0.625 5.6 5 6 abnormal amnion morphology 0.0871800539421874 0.258013544534433 0.844538397560299 0.625 5.6 5 6 decreased skeletal muscle weight 0.0871800539421874 0.258013544534433 0.844538397560299 0.625 5.6 5 6 abnormal pulmonary alveolus wall morphology 0.0871800539421874 0.258013544534433 0.844538397560299 0.625 5.6 5 6 decreased midbrain size 0.0871800539421874 0.258013544534433 0.844538397560299 0.625 5.6 5 6 failure of vascular branching 0.215257591735681 0.437489008524116 0.844538397560299 0.625 5.6 5 6 schistocytosis 0.215257591735681 0.437489008524116 0.844538397560299 0.625 5.6 5 6 abnormal cecum morphology 0.215257591735681 0.437489008524116 0.844538397560299 0.625 5.6 5 6 abnormal hypoglossal nerve morphology 0.215257591735681 0.437489008524116 0.844538397560299 0.625 5.6 5 6 unidirectional circling 0.215257591735681 0.437489008524116 0.844538397560299 0.625 5.6 5 6 abnormal atrial thrombosis 0.215257591735681 0.437489008524116 0.844538397560299 0.625 5.6 5 6 coarse hair 0.215257591735681 0.437489008524116 0.844538397560299 0.625 5.6 5 6 decreased corneal stroma thickness 0.215257591735681 0.437489008524116 0.844538397560299 0.625 5.6 5 6 hypospadia 0.215257591735681 0.437489008524116 0.844538397560299 0.625 5.6 5 6 early eyelid opening 0.215257591735681 0.437489008524116 0.844538397560299 0.625 5.6 5 6 abnormal cellular cholesterol metabolism 0.215257591735681 0.437489008524116 0.844538397560299 0.625 5.6 5 6 loss of GABAergic neurons 0.215257591735681 0.437489008524116 0.844538397560299 0.625 5.6 5 6 liver failure 0.215257591735681 0.437489008524116 0.844538397560299 0.625 5.6 5 6 hair follicle degeneration 0.215257591735681 0.437489008524116 0.844538397560299 0.625 5.6 5 6 abnormal forelimb zeugopod morphology 0.215257591735681 0.437489008524116 0.844538397560299 0.625 5.6 5 6 abnormal skin development 0.215257591735681 0.437489008524116 0.844538397560299 0.625 5.6 5 6 abnormal lateral ganglionic eminence morphology 0.215257591735681 0.437489008524116 0.844538397560299 0.625 5.6 5 6 small frontal bone 0.215257591735681 0.437489008524116 0.844538397560299 0.625 5.6 5 6 non-pigmented tail tip 0.215257591735681 0.437489008524116 0.844538397560299 0.625 5.6 5 6 abnormal vertebral body development 0.215257591735681 0.437489008524116 0.844538397560299 0.625 5.6 5 6 Sertoli cell hypoplasia 0.215257591735681 0.437489008524116 0.844538397560299 0.625 5.6 5 6 abnormal circulating corticosterone level 0.215257591735681 0.437489008524116 0.844538397560299 0.625 5.6 5 6 choroidal neovascularization 0.215257591735681 0.437489008524116 0.844538397560299 0.625 5.6 5 6 impaired behavioral response to alcohol 0.215257591735681 0.437489008524116 0.844538397560299 0.625 5.6 5 6 abnormal frontonasal prominence morphology 0.215257591735681 0.437489008524116 0.844538397560299 0.625 5.6 5 6 abnormal circulating serum amyloid protein level 0.215257591735681 0.437489008524116 0.844538397560299 0.625 5.6 5 6 anomalous pulmonary venous connection 0.215257591735681 0.437489008524116 0.844538397560299 0.625 5.6 5 6 myocardial trabeculae hypoplasia 0.215257591735681 0.437489008524116 0.844538397560299 0.625 5.6 5 6 increased heart right ventricle size 0.215257591735681 0.437489008524116 0.844538397560299 0.625 5.6 5 6 delayed suture closure 0.215257591735681 0.437489008524116 0.844538397560299 0.625 5.6 5 6 impaired mucociliary clearance 0.215257591735681 0.437489008524116 0.844538397560299 0.625 5.6 5 6 abnormal bronchus epithelium morphology 0.215257591735681 0.437489008524116 0.844538397560299 0.625 5.6 5 6 absent ureteric bud 0.215257591735681 0.437489008524116 0.844538397560299 0.625 5.6 5 6 decreased cranium length 0.215257591735681 0.437489008524116 0.844538397560299 0.625 5.6 5 6 increased cornea thickness 0.215257591735681 0.437489008524116 0.844538397560299 0.625 5.6 5 6 increased testis apoptosis 0.215257591735681 0.437489008524116 0.844538397560299 0.625 5.6 5 6 decreased white adipose tissue mass 0.215257591735681 0.437489008524116 0.844538397560299 0.625 5.6 5 6 cachexia 3.15822365988036e-05 0.000483451160243225 0.844538397560299 0.625 5.6 5 6 abnormal seminal vesicle morphology 0.002037191099213 0.0162420283951677 0.844538397560299 0.625 5.6 5 6 abnormal cardiovascular system morphology 0.00416351553668082 0.0285703307517063 0.844538397560299 0.625 5.6 5 6 abnormal malleus morphology 0.0388513709250378 0.151954064742188 0.844538397560299 0.625 5.6 5 6 abnormal digestive system morphology 0.0388513709250378 0.151954064742188 0.844538397560299 0.625 5.6 5 6 small lymph nodes 0.0388513709250378 0.151954064742188 0.844538397560299 0.625 5.6 5 6 increased body temperature 0.0388513709250378 0.151954064742188 0.844538397560299 0.625 5.6 5 6 abnormal truncus arteriosus septation 0.0388513709250378 0.151954064742188 0.844538397560299 0.625 5.6 5 6 abnormal lung saccule morphology 0.0388513709250378 0.151954064742188 0.844538397560299 0.625 5.6 5 6 no abnormal phenotype detected 1.20922921504525e-65 2.00530511495003e-62 0.84346751313688 0.624207492795389 5.6 5 6 abnormal cardiovascular system physiology 2.97322592103891e-06 6.08716006467842e-05 0.843268415007577 0.62406015037594 5.6 5 6 hypoglycemia 9.00362211856566e-05 0.00116454083819406 0.842722185952643 0.623655913978495 5.6 5 6 abnormal definitive hematopoiesis 9.00362211856566e-05 0.00116454083819406 0.842722185952643 0.623655913978495 5.6 5 6 abnormal seminiferous tubule morphology 1.09791148236172e-06 2.50555487373834e-05 0.842224593731367 0.623287671232877 5.6 5 6 hyperkeratosis 0.000720467179170023 0.00688939557884075 0.842090460176067 0.623188405797101 5.6 5 6 abnormal food intake 0.000720467179170023 0.00688939557884075 0.842090460176067 0.623188405797101 5.6 5 6 abnormal placenta development 0.00295903114901135 0.0215537041966786 0.841351460211015 0.622641509433962 5.6 5 6 thin ventricular wall 0.000129339629696445 0.00160465001930128 0.840784893571142 0.622222222222222 5.6 5 6 malocclusion 0.012627764273062 0.0684706935924497 0.839973325141055 0.621621621621622 5.6 5 6 abnormal branching of the mammary ductal tree 0.012627764273062 0.0684706935924497 0.839973325141055 0.621621621621622 5.6 5 6 decreased circulating chloride level 0.012627764273062 0.0684706935924497 0.839973325141055 0.621621621621622 5.6 5 6 abnormal chromosome morphology 0.012627764273062 0.0684706935924497 0.839973325141055 0.621621621621622 5.6 5 6 abnormal humerus morphology 0.012627764273062 0.0684706935924497 0.839973325141055 0.621621621621622 5.6 5 6 increased trabecular bone volume 0.012627764273062 0.0684706935924497 0.839973325141055 0.621621621621622 5.6 5 6 abnormal respiratory electron transport chain 0.012627764273062 0.0684706935924497 0.839973325141055 0.621621621621622 5.6 5 6 decreased B cell number 1.06353110787731e-08 3.70004703614658e-07 0.839618756409463 0.621359223300971 5.6 5 6 short limbs 0.000185770147020035 0.00221632249742128 0.838713994818504 0.620689655172414 5.6 5 6 thrombocytosis 0.00210693861472934 0.0167712313732456 0.838713994818504 0.620689655172414 5.6 5 6 polychromatophilia 0.0267474508406779 0.118917397616061 0.838713994818504 0.620689655172414 5.6 5 6 increased body weight 2.88402841814778e-09 1.13873344287978e-07 0.838505980434869 0.620535714285714 5.6 5 6 decreased B cell proliferation 0.000371214799759201 0.00401476875826527 0.838124181882626 0.620253164556962 5.6 5 6 increased monocyte cell number 6.7312777308343e-05 0.000902644385738562 0.837782090379817 0.62 5.6 5 6 decreased double-positive T cell number 6.7312777308343e-05 0.000902644385738562 0.837782090379817 0.62 5.6 5 6 abnormal interventricular septum morphology 0.0043000544032559 0.0294666262482068 0.837782090379817 0.62 5.6 5 6 abnormal ovary morphology 0.000744921321694801 0.00707248773937335 0.837401453355564 0.619718309859155 5.6 5 6 small testis 5.58085339419315e-11 3.01790713435988e-09 0.837194585407601 0.619565217391304 5.6 5 6 increased total body fat amount 4.56278432636182e-06 9.00787778716273e-05 0.836975367134386 0.619402985074627 5.6 5 6 hydronephrosis 0.000266770912478071 0.00303010340086394 0.836495174726392 0.619047619047619 5.6 5 6 arrest of spermatogenesis 0.000266770912478071 0.00303010340086394 0.836495174726392 0.619047619047619 5.6 5 6 abnormal associative learning 0.0583726411578265 0.20422214469774 0.836495174726392 0.619047619047619 5.6 5 6 abnormal stapes morphology 0.0583726411578265 0.20422214469774 0.836495174726392 0.619047619047619 5.6 5 6 increased keratinocyte proliferation 0.0583726411578265 0.20422214469774 0.836495174726392 0.619047619047619 5.6 5 6 complete atrioventricular septal defect 0.0583726411578265 0.20422214469774 0.836495174726392 0.619047619047619 5.6 5 6 weight loss 2.37584285728707e-07 6.15615532031414e-06 0.833921343419541 0.617142857142857 5.6 5 6 abnormal T-helper 1 physiology 0.00625184857159521 0.0384937458461462 0.833757056314849 0.617021276595745 5.6 5 6 abnormal B cell differentiation 0.00019762236762814 0.00231880018620282 0.831545499136295 0.615384615384615 5.6 5 6 abnormal snout morphology 0.00442107365207104 0.0301976879869992 0.831545499136295 0.615384615384615 5.6 5 6 absent corpus luteum 0.00442107365207104 0.0301976879869992 0.831545499136295 0.615384615384615 5.6 5 6 abnormal nasal bone morphology 0.0397221277326209 0.154509449155425 0.831545499136295 0.615384615384615 5.6 5 6 abnormal xiphoid process morphology 0.0397221277326209 0.154509449155425 0.831545499136295 0.615384615384615 5.6 5 6 ventricular hypoplasia 0.0397221277326209 0.154509449155425 0.831545499136295 0.615384615384615 5.6 5 6 decreased bone resorption 0.0397221277326209 0.154509449155425 0.831545499136295 0.615384615384615 5.6 5 6 short hair 0.134744620581592 0.346257483157758 0.831545499136295 0.615384615384615 5.6 5 6 abnormal renal/urinary system morphology 0.134744620581592 0.346257483157758 0.831545499136295 0.615384615384615 5.6 5 6 abnormal sympathetic ganglion morphology 0.134744620581592 0.346257483157758 0.831545499136295 0.615384615384615 5.6 5 6 small trigeminal ganglion 0.134744620581592 0.346257483157758 0.831545499136295 0.615384615384615 5.6 5 6 pup cannibalization 0.134744620581592 0.346257483157758 0.831545499136295 0.615384615384615 5.6 5 6 abnormal digestion 0.134744620581592 0.346257483157758 0.831545499136295 0.615384615384615 5.6 5 6 dystrophic cardiac calcinosis 0.134744620581592 0.346257483157758 0.831545499136295 0.615384615384615 5.6 5 6 abnormal soleus morphology 0.134744620581592 0.346257483157758 0.831545499136295 0.615384615384615 5.6 5 6 abnormal dopaminergic neuron morphology 0.134744620581592 0.346257483157758 0.831545499136295 0.615384615384615 5.6 5 6 abnormal GABAergic neuron morphology 0.134744620581592 0.346257483157758 0.831545499136295 0.615384615384615 5.6 5 6 tracheoesophageal fistula 0.134744620581592 0.346257483157758 0.831545499136295 0.615384615384615 5.6 5 6 abnormal insulin secretion 0.134744620581592 0.346257483157758 0.831545499136295 0.615384615384615 5.6 5 6 small interparietal bone 0.134744620581592 0.346257483157758 0.831545499136295 0.615384615384615 5.6 5 6 increased circulating ammonia level 0.134744620581592 0.346257483157758 0.831545499136295 0.615384615384615 5.6 5 6 hyperalgesia 0.134744620581592 0.346257483157758 0.831545499136295 0.615384615384615 5.6 5 6 increased circulating thyroxine level 0.134744620581592 0.346257483157758 0.831545499136295 0.615384615384615 5.6 5 6 empty decidua capsularis 0.134744620581592 0.346257483157758 0.831545499136295 0.615384615384615 5.6 5 6 abnormal lipid homeostasis 9.56879597475169e-06 0.000167986564341044 0.831545499136295 0.615384615384615 5.6 5 6 abnormal spleen morphology 3.48046432153405e-07 8.58249836015258e-06 0.830948124496111 0.614942528735632 5.6 5 6 cochlear hair cell degeneration 0.00909394888154624 0.0539885390044064 0.829183153968294 0.613636363636364 5.6 5 6 osteopetrosis 0.0273320259913308 0.121299580113176 0.82819249309139 0.612903225806452 5.6 5 6 abnormal nose morphology 0.0273320259913308 0.121299580113176 0.82819249309139 0.612903225806452 5.6 5 6 abnormal respiratory system physiology 0.00640599049760197 0.0393940701181333 0.827302920059069 0.612244897959184 5.6 5 6 abnormal digit morphology 0.00113149193208542 0.0100163209290479 0.825770877614515 0.611111111111111 5.6 5 6 abnormal uterus morphology 0.018959893040818 0.0905234816488193 0.825770877614515 0.611111111111111 5.6 5 6 abnormal reflex 0.018959893040818 0.0905234816488193 0.825770877614515 0.611111111111111 5.6 5 6 renal hypoplasia 0.018959893040818 0.0905234816488193 0.825770877614515 0.611111111111111 5.6 5 6 narrow eye opening 0.018959893040818 0.0905234816488193 0.825770877614515 0.611111111111111 5.6 5 6 abnormal retinal blood vessel morphology 0.018959893040818 0.0905234816488193 0.825770877614515 0.611111111111111 5.6 5 6 abnormal metacarpal bone morphology 0.0882291352300904 0.259020239244477 0.825770877614515 0.611111111111111 5.6 5 6 abnormal redox activity 0.0882291352300904 0.259020239244477 0.825770877614515 0.611111111111111 5.6 5 6 increased circulating renin level 0.0882291352300904 0.259020239244477 0.825770877614515 0.611111111111111 5.6 5 6 increased circulating glycerol level 0.0882291352300904 0.259020239244477 0.825770877614515 0.611111111111111 5.6 5 6 decreased activity of thyroid 0.0882291352300904 0.259020239244477 0.825770877614515 0.611111111111111 5.6 5 6 abnormal sperm axoneme morphology 0.0882291352300904 0.259020239244477 0.825770877614515 0.611111111111111 5.6 5 6 increased effector memory CD8-positive, alpha-beta T cell number 0.0882291352300904 0.259020239244477 0.825770877614515 0.611111111111111 5.6 5 6 abnormal aerobic respiration 0.0882291352300904 0.259020239244477 0.825770877614515 0.611111111111111 5.6 5 6 abnormal chondrocyte morphology 0.00452733566196667 0.0308118945530564 0.825770877614515 0.611111111111111 5.6 5 6 enlarged liver 0.000149614797675716 0.00181103070179243 0.824269476018852 0.61 5.6 5 6 abnormal liver physiology 0.000149614797675716 0.00181103070179243 0.824269476018852 0.61 5.6 5 6 arrested B cell differentiation 0.0132342493073216 0.0707581731933409 0.823939900058829 0.609756097560976 5.6 5 6 hemopericardium 0.0132342493073216 0.0707581731933409 0.823939900058829 0.609756097560976 5.6 5 6 abnormal cholesterol homeostasis 0.0132342493073216 0.0707581731933409 0.823939900058829 0.609756097560976 5.6 5 6 abnormal blood vessel physiology 0.0591883441128267 0.205917490882037 0.822506961102205 0.608695652173913 5.6 5 6 abnormal pulmonary artery morphology 0.0591883441128267 0.205917490882037 0.822506961102205 0.608695652173913 5.6 5 6 blistering 0.0591883441128267 0.205917490882037 0.822506961102205 0.608695652173913 5.6 5 6 abnormal circulating insulin level 0.0591883441128267 0.205917490882037 0.822506961102205 0.608695652173913 5.6 5 6 abnormal cardiovascular development 0.0591883441128267 0.205917490882037 0.822506961102205 0.608695652173913 5.6 5 6 abnormal sacral vertebrae morphology 0.0591883441128267 0.205917490882037 0.822506961102205 0.608695652173913 5.6 5 6 abnormal sternum morphology 0.00162231930466312 0.013564770656637 0.822506961102205 0.608695652173913 5.6 5 6 abnormal neuron differentiation 7.91452805081073e-05 0.00104166076859215 0.820408729058577 0.607142857142857 5.6 5 6 shortened head 0.0403210729094057 0.156472182312241 0.820408729058577 0.607142857142857 5.6 5 6 abnormal respiration 0.0403210729094057 0.156472182312241 0.820408729058577 0.607142857142857 5.6 5 6 abnormal aorta morphology 0.0277631288367562 0.12139078129387 0.818946324906957 0.606060606060606 5.6 5 6 abnormal epidermis stratum basale morphology 0.0277631288367562 0.12139078129387 0.818946324906957 0.606060606060606 5.6 5 6 dilated heart atrium 0.0277631288367562 0.12139078129387 0.818946324906957 0.606060606060606 5.6 5 6 increased osteoblast cell number 0.0277631288367562 0.12139078129387 0.818946324906957 0.606060606060606 5.6 5 6 head tossing 0.0277631288367562 0.12139078129387 0.818946324906957 0.606060606060606 5.6 5 6 increased bone marrow cell number 0.019267801140783 0.0917294838998999 0.817868763953132 0.605263157894737 5.6 5 6 abnormal retinal outer nuclear layer morphology 0.019267801140783 0.0917294838998999 0.817868763953132 0.605263157894737 5.6 5 6 abnormal organ of Corti morphology 0.0134535379902564 0.0707581731933409 0.817041798569964 0.604651162790698 5.6 5 6 abnormal homeostasis 0.0134535379902564 0.0707581731933409 0.817041798569964 0.604651162790698 5.6 5 6 abnormal phalanx morphology 0.00943930425646445 0.0558389282709996 0.816387117641623 0.604166666666667 5.6 5 6 abnormal enzyme/coenzyme level 0.00469877898223316 0.0318718842422328 0.815416383851324 0.603448275862069 5.6 5 6 abnormal eye electrophysiology 5.92588191486091e-05 0.000821205084301756 0.815223841611926 0.603305785123967 5.6 5 6 abnormal hair follicle morphology 0.00332976631835802 0.0237437416208666 0.815046580502638 0.603174603174603 5.6 5 6 short femur 0.00061299565635122 0.00600325470540811 0.813827910376289 0.602272727272727 5.6 5 6 decreased circulating phosphate level 0.0194962140388729 0.0926396034798403 0.810756861657888 0.6 5.6 5 6 abnormal female reproductive system morphology 0.0194962140388729 0.0926396034798403 0.810756861657888 0.6 5.6 5 6 increased circulating serum albumin level 0.0280620076629496 0.121610181291964 0.810756861657888 0.6 5.6 5 6 abnormal trachea morphology 0.0885375456528837 0.259114658881415 0.810756861657888 0.6 5.6 5 6 decreased circulating VLDL cholesterol level 0.0885375456528837 0.259114658881415 0.810756861657888 0.6 5.6 5 6 abnormal induced retinal neovascularization 0.0885375456528837 0.259114658881415 0.810756861657888 0.6 5.6 5 6 abnormal lateral semicircular canal morphology 0.211589922296742 0.437489008524116 0.810756861657888 0.6 5.6 5 6 abnormal auchene hair morphology 0.211589922296742 0.437489008524116 0.810756861657888 0.6 5.6 5 6 absent maxillary shelf 0.211589922296742 0.437489008524116 0.810756861657888 0.6 5.6 5 6 jaundice 0.211589922296742 0.437489008524116 0.810756861657888 0.6 5.6 5 6 abnormal prostate gland epithelium morphology 0.211589922296742 0.437489008524116 0.810756861657888 0.6 5.6 5 6 absent trophoblast giant cells 0.211589922296742 0.437489008524116 0.810756861657888 0.6 5.6 5 6 abnormal neuron specification 0.211589922296742 0.437489008524116 0.810756861657888 0.6 5.6 5 6 abnormal primordial germ cell migration 0.211589922296742 0.437489008524116 0.810756861657888 0.6 5.6 5 6 abnormal hindlimb zeugopod morphology 0.211589922296742 0.437489008524116 0.810756861657888 0.6 5.6 5 6 absent pharyngeal arches 0.211589922296742 0.437489008524116 0.810756861657888 0.6 5.6 5 6 abnormal gonadal fat pad morphology 0.211589922296742 0.437489008524116 0.810756861657888 0.6 5.6 5 6 abnormal developmental vascular remodeling 0.211589922296742 0.437489008524116 0.810756861657888 0.6 5.6 5 6 protruding tongue 0.211589922296742 0.437489008524116 0.810756861657888 0.6 5.6 5 6 abnormal retinal blood vessel pattern 0.211589922296742 0.437489008524116 0.810756861657888 0.6 5.6 5 6 acanthocytosis 0.211589922296742 0.437489008524116 0.810756861657888 0.6 5.6 5 6 abnormal vibrissa follicle morphology 0.211589922296742 0.437489008524116 0.810756861657888 0.6 5.6 5 6 abnormal heart and great artery attachment 0.211589922296742 0.437489008524116 0.810756861657888 0.6 5.6 5 6 aorta stenosis 0.211589922296742 0.437489008524116 0.810756861657888 0.6 5.6 5 6 sinus bradycardia 0.211589922296742 0.437489008524116 0.810756861657888 0.6 5.6 5 6 abnormal pulmonary interalveolar septum morphology 0.211589922296742 0.437489008524116 0.810756861657888 0.6 5.6 5 6 decreased trabecular bone connectivity density 0.211589922296742 0.437489008524116 0.810756861657888 0.6 5.6 5 6 decreased macrophage apoptosis 0.211589922296742 0.437489008524116 0.810756861657888 0.6 5.6 5 6 increased fatty acid oxidation 0.211589922296742 0.437489008524116 0.810756861657888 0.6 5.6 5 6 circling 0.000870436108963896 0.00817060309829318 0.810756861657887 0.6 5.6 5 6 spleen hyperplasia 0.00170880969058565 0.014168880351106 0.810756861657887 0.6 5.6 5 6 epidermal hyperplasia 0.00476557311162624 0.0318718842422328 0.810756861657887 0.6 5.6 5 6 abnormal joint morphology 0.00674075520869537 0.0413505020508748 0.810756861657887 0.6 5.6 5 6 abnormal hindlimb morphology 0.00956489463912111 0.0561288955863018 0.810756861657887 0.6 5.6 5 6 abnormal ovarian follicle morphology 0.0136240212007124 0.0707581731933409 0.810756861657887 0.6 5.6 5 6 abnormal heart tube morphology 0.0406941356057381 0.157673928846221 0.810756861657887 0.6 5.6 5 6 abnormal hair cycle 0.0406941356057381 0.157673928846221 0.810756861657887 0.6 5.6 5 6 abnormal inner ear vestibule morphology 0.0596044421837133 0.206124571746635 0.810756861657887 0.6 5.6 5 6 impaired conditioned place preference behavior 0.0596044421837133 0.206124571746635 0.810756861657887 0.6 5.6 5 6 decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 0.0596044421837133 0.206124571746635 0.810756861657887 0.6 5.6 5 6 abnormal fontanelle morphology 0.134359170634796 0.346257483157758 0.810756861657887 0.6 5.6 5 6 decreased chondrocyte number 0.134359170634796 0.346257483157758 0.810756861657887 0.6 5.6 5 6 interdigital webbing 0.134359170634796 0.346257483157758 0.810756861657887 0.6 5.6 5 6 placental labyrinth hypoplasia 0.134359170634796 0.346257483157758 0.810756861657887 0.6 5.6 5 6 increased alcohol consumption 0.134359170634796 0.346257483157758 0.810756861657887 0.6 5.6 5 6 abnormal rostral migratory stream morphology 0.134359170634796 0.346257483157758 0.810756861657887 0.6 5.6 5 6 liver vascular congestion 0.134359170634796 0.346257483157758 0.810756861657887 0.6 5.6 5 6 bicuspid aortic valve 0.134359170634796 0.346257483157758 0.810756861657887 0.6 5.6 5 6 infertility 0.000232617009643814 0.00271023330908191 0.808231139347427 0.598130841121495 5.6 5 6 abnormal renal glomerulus morphology 0.000235622397005629 0.00273883510538085 0.805798104094231 0.596330275229358 5.6 5 6 decreased IgA level 0.00966262105525488 0.0565547526469329 0.805559702288286 0.596153846153846 5.6 5 6 increased percent body fat/body weight 0.00966262105525488 0.0565547526469329 0.805559702288286 0.596153846153846 5.6 5 6 deafness 0.000457662302549459 0.00482387702369398 0.805297219491841 0.595959595959596 5.6 5 6 increased circulating glucose level 3.31578831039602e-05 0.000499821526576966 0.805006812993647 0.595744680851064 5.6 5 6 hepatic necrosis 0.0137505594213394 0.0707581731933409 0.805006812993647 0.595744680851064 5.6 5 6 abnormal muscle morphology 0.0196544234701829 0.093035924609096 0.804322283390761 0.595238095238095 5.6 5 6 increased granulocyte number 0.00245581993496388 0.0189287452437854 0.803452745787096 0.594594594594595 5.6 5 6 small seminiferous tubules 0.00245581993496388 0.0189287452437854 0.803452745787096 0.594594594594595 5.6 5 6 abnormal heart atrium morphology 0.040879157316047 0.157763175320909 0.802311477682285 0.59375 5.6 5 6 abnormal colon morphology 0.00687215070420856 0.041795782094667 0.801595767175877 0.593220338983051 5.6 5 6 increased bone mineral density 0.000240776710585317 0.00277926713494652 0.801190409012957 0.592920353982301 5.6 5 6 abnormal skeleton development 0.00176586893293212 0.0146042726003294 0.800747517686802 0.592592592592593 5.6 5 6 diluted coat color 0.00973492944132914 0.0569110152416128 0.800747517686802 0.592592592592593 5.6 5 6 abnormal heart valve morphology 0.059703619675759 0.206124571746635 0.800747517686802 0.592592592592593 5.6 5 6 wrinkled skin 0.059703619675759 0.206124571746635 0.800747517686802 0.592592592592593 5.6 5 6 abnormal palate morphology 0.059703619675759 0.206124571746635 0.800747517686802 0.592592592592593 5.6 5 6 abnormal bone trabecula morphology 0.059703619675759 0.206124571746635 0.800747517686802 0.592592592592593 5.6 5 6 increased circulating free fatty acid level 0.00348010016689719 0.0245930374010135 0.799337750930311 0.591549295774648 5.6 5 6 renal interstitial fibrosis 0.0197507222583932 0.0933141911068433 0.798472666784283 0.590909090909091 5.6 5 6 abnormal facial nerve morphology 0.0883011710067603 0.259020239244477 0.798472666784283 0.590909090909091 5.6 5 6 abnormal cochlear sensory epithelium morphology 0.0883011710067603 0.259020239244477 0.798472666784283 0.590909090909091 5.6 5 6 parakeratosis 0.0883011710067603 0.259020239244477 0.798472666784283 0.590909090909091 5.6 5 6 decreased circulating estradiol level 0.0883011710067603 0.259020239244477 0.798472666784283 0.590909090909091 5.6 5 6 enlarged spleen 1.15419119577108e-08 3.90619129181027e-07 0.797619597695838 0.590277777777778 5.6 5 6 abnormal response to injury 0.028333995904776 0.122468835470252 0.796897770005616 0.58974358974359 5.6 5 6 decreased circulating alanine transaminase level 0.00492477013433921 0.0325374919234231 0.794859668292047 0.588235294117647 5.6 5 6 short maxilla 0.0409074364148688 0.157763175320909 0.794859668292047 0.588235294117647 5.6 5 6 abnormal oocyte morphology 0.0409074364148688 0.157763175320909 0.794859668292047 0.588235294117647 5.6 5 6 thin skin 0.0409074364148688 0.157763175320909 0.794859668292047 0.588235294117647 5.6 5 6 decreased pancreatic beta cell number 0.0409074364148688 0.157763175320909 0.794859668292047 0.588235294117647 5.6 5 6 increased susceptibility to weight gain 0.0409074364148688 0.157763175320909 0.794859668292047 0.588235294117647 5.6 5 6 hydroureter 0.133036956390205 0.346257483157758 0.794859668292047 0.588235294117647 5.6 5 6 increased aggression towards mice 0.133036956390205 0.346257483157758 0.794859668292047 0.588235294117647 5.6 5 6 abnormal cranial suture morphology 0.133036956390205 0.346257483157758 0.794859668292047 0.588235294117647 5.6 5 6 decreased vasoconstriction 0.133036956390205 0.346257483157758 0.794859668292047 0.588235294117647 5.6 5 6 aminoaciduria 0.133036956390205 0.346257483157758 0.794859668292047 0.588235294117647 5.6 5 6 pancytopenia 0.133036956390205 0.346257483157758 0.794859668292047 0.588235294117647 5.6 5 6 increased trabecular bone mass 0.133036956390205 0.346257483157758 0.794859668292047 0.588235294117647 5.6 5 6 delayed heart development 0.133036956390205 0.346257483157758 0.794859668292047 0.588235294117647 5.6 5 6 abnormal gluconeogenesis 0.013889240679224 0.0707581731933409 0.794859668292046 0.588235294117647 5.6 5 6 increased kidney weight 0.013889240679224 0.0707581731933409 0.794859668292046 0.588235294117647 5.6 5 6 cochlear inner hair cell degeneration 0.013889240679224 0.0707581731933409 0.794859668292046 0.588235294117647 5.6 5 6 abnormal bone mineralization 0.000247869007495237 0.00283482370641104 0.792888941841736 0.586776859504132 5.6 5 6 dermatitis 0.00981225728822313 0.0572957511841667 0.792118772884143 0.586206896551724 5.6 5 6 abnormal middle ear morphology 0.0595503708401033 0.206124571746635 0.792118772884143 0.586206896551724 5.6 5 6 abnormal parietal bone morphology 0.0595503708401033 0.206124571746635 0.792118772884143 0.586206896551724 5.6 5 6 decreased bone strength 0.0595503708401033 0.206124571746635 0.792118772884143 0.586206896551724 5.6 5 6 thick epidermis 0.00494122591599673 0.0326029163555487 0.791453126856509 0.585714285714286 5.6 5 6 polyuria 0.00352573374512934 0.0248772093668709 0.789698241874566 0.584415584415584 5.6 5 6 abnormal kidney physiology 0.0197863166521643 0.0933936673097889 0.788235837722946 0.583333333333333 5.6 5 6 hemolytic anemia 0.0876601065757311 0.258972108203244 0.788235837722946 0.583333333333333 5.6 5 6 decreased fatty acid level 0.0876601065757311 0.258972108203244 0.788235837722946 0.583333333333333 5.6 5 6 increased circulating total protein level 0.0876601065757311 0.258972108203244 0.788235837722946 0.583333333333333 5.6 5 6 abnormal rectum morphology 0.206570639894611 0.437489008524116 0.788235837722946 0.583333333333333 5.6 5 6 amyloidosis 0.206570639894611 0.437489008524116 0.788235837722946 0.583333333333333 5.6 5 6 abnormal superior cervical ganglion morphology 0.206570639894611 0.437489008524116 0.788235837722946 0.583333333333333 5.6 5 6 abnormal glossopharyngeal nerve morphology 0.206570639894611 0.437489008524116 0.788235837722946 0.583333333333333 5.6 5 6 impaired embryo implantation 0.206570639894611 0.437489008524116 0.788235837722946 0.583333333333333 5.6 5 6 altered tumor susceptibility 0.206570639894611 0.437489008524116 0.788235837722946 0.583333333333333 5.6 5 6 increased growth rate 0.206570639894611 0.437489008524116 0.788235837722946 0.583333333333333 5.6 5 6 increased circulating parathyroid hormone level 0.206570639894611 0.437489008524116 0.788235837722946 0.583333333333333 5.6 5 6 small thyroid gland 0.206570639894611 0.437489008524116 0.788235837722946 0.583333333333333 5.6 5 6 small intestinal inflammation 0.206570639894611 0.437489008524116 0.788235837722946 0.583333333333333 5.6 5 6 absent tail 0.206570639894611 0.437489008524116 0.788235837722946 0.583333333333333 5.6 5 6 increased fear-related response 0.206570639894611 0.437489008524116 0.788235837722946 0.583333333333333 5.6 5 6 impaired sperm capacitation 0.206570639894611 0.437489008524116 0.788235837722946 0.583333333333333 5.6 5 6 abnormal thymus corticomedullary boundary morphology 0.206570639894611 0.437489008524116 0.788235837722946 0.583333333333333 5.6 5 6 reduced cerebellar foliation 0.206570639894611 0.437489008524116 0.788235837722946 0.583333333333333 5.6 5 6 decreased prostaglandin level 0.206570639894611 0.437489008524116 0.788235837722946 0.583333333333333 5.6 5 6 increased skeletal muscle glycogen level 0.206570639894611 0.437489008524116 0.788235837722946 0.583333333333333 5.6 5 6 increased type II pneumocyte number 0.206570639894611 0.437489008524116 0.788235837722946 0.583333333333333 5.6 5 6 abnormal placenta labyrinth morphology 0.00353031353025344 0.0248772093668709 0.786810456461241 0.582278481012658 5.6 5 6 increased circulating calcium level 0.0139007370693412 0.0707581731933409 0.786188471910679 0.581818181818182 5.6 5 6 decreased circulating calcium level 0.0139007370693412 0.0707581731933409 0.786188471910679 0.581818181818182 5.6 5 6 abnormal male reproductive system morphology 0.0282667644145254 0.122284480836751 0.785617114009581 0.581395348837209 5.6 5 6 kidney failure 0.0282667644145254 0.122284480836751 0.785617114009581 0.581395348837209 5.6 5 6 abnormal angiogenesis 0.00495079579013763 0.0326227934515692 0.785192456110116 0.581081081081081 5.6 5 6 decreased litter size 1.16017859113301e-07 3.11993972480363e-06 0.783827808127139 0.580071174377224 5.6 5 6 increased body length 0.0197380245622021 0.0933141911068433 0.783731632935958 0.58 5.6 5 6 abnormal lung morphology 0.000483036097891752 0.00501691980586945 0.783504530173589 0.579831932773109 5.6 5 6 increased T cell number 0.00252303094037552 0.0189608443026711 0.783117423192278 0.579545454545455 5.6 5 6 irregular coat pigmentation 0.131100253095504 0.346257483157758 0.782309252476909 0.578947368421053 5.6 5 6 enlarged adrenal glands 0.131100253095504 0.346257483157758 0.782309252476909 0.578947368421053 5.6 5 6 short vibrissae 0.131100253095504 0.346257483157758 0.782309252476909 0.578947368421053 5.6 5 6 stereotypic behavior 0.131100253095504 0.346257483157758 0.782309252476909 0.578947368421053 5.6 5 6 abnormal neural crest cell migration 0.131100253095504 0.346257483157758 0.782309252476909 0.578947368421053 5.6 5 6 increased susceptibility to ischemic brain injury 0.131100253095504 0.346257483157758 0.782309252476909 0.578947368421053 5.6 5 6 oliguria 0.131100253095504 0.346257483157758 0.782309252476909 0.578947368421053 5.6 5 6 increased left ventricle weight 0.131100253095504 0.346257483157758 0.782309252476909 0.578947368421053 5.6 5 6 increased circulating VLDL cholesterol level 0.131100253095504 0.346257483157758 0.782309252476909 0.578947368421053 5.6 5 6 eyelids fail to open 0.131100253095504 0.346257483157758 0.782309252476909 0.578947368421053 5.6 5 6 decreased fertilization frequency 0.131100253095504 0.346257483157758 0.782309252476909 0.578947368421053 5.6 5 6 increased liver cholesterol level 0.131100253095504 0.346257483157758 0.782309252476909 0.578947368421053 5.6 5 6 abnormal blood homeostasis 0.000670470898531545 0.00651482953162976 0.782309252476909 0.578947368421053 5.6 5 6 abnormal lens morphology 0.000348258640044131 0.00385019274271011 0.781198017743277 0.578125 5.6 5 6 abnormal hair growth 0.0196528128937272 0.093035924609096 0.779573905440276 0.576923076923077 5.6 5 6 abnormal female meiosis 0.0196528128937272 0.093035924609096 0.779573905440276 0.576923076923077 5.6 5 6 decreased body temperature 0.0196528128937272 0.093035924609096 0.779573905440276 0.576923076923077 5.6 5 6 abnormal Schwann cell morphology 0.0867166891624756 0.258013544534433 0.779573905440276 0.576923076923077 5.6 5 6 abnormal ocular fundus morphology 0.0867166891624756 0.258013544534433 0.779573905440276 0.576923076923077 5.6 5 6 syndactyly 0.0138108022424829 0.0707581731933409 0.778693030970852 0.576271186440678 5.6 5 6 increased B cell proliferation 0.0138108022424829 0.0707581731933409 0.778693030970852 0.576271186440678 5.6 5 6 enlarged pericardium 0.0586794816807989 0.205007318372173 0.777999008661609 0.575757575757576 5.6 5 6 abnormal middle ear ossicle morphology 0.0586794816807989 0.205007318372173 0.777999008661609 0.575757575757576 5.6 5 6 abnormal tibia morphology 0.0279491114461054 0.12139078129387 0.776256569672445 0.574468085106383 5.6 5 6 decreased bone trabecula number 0.0279491114461054 0.12139078129387 0.776256569672445 0.574468085106383 5.6 5 6 abnormal long bone morphology 0.0137345715419712 0.0707581731933409 0.775313938743881 0.573770491803279 5.6 5 6 abnormal dermal layer morphology 0.058034674750761 0.20361248722499 0.772149392055131 0.571428571428571 5.6 5 6 ovary cysts 0.058034674750761 0.20361248722499 0.772149392055131 0.571428571428571 5.6 5 6 small ovary 0.0034705048943866 0.0245601164289806 0.772149392055131 0.571428571428571 5.6 5 6 skin lesions 0.0136406074169518 0.0707581731933409 0.772149392055131 0.571428571428571 5.6 5 6 organ of Corti degeneration 0.0277179265792966 0.12139078129387 0.772149392055131 0.571428571428571 5.6 5 6 abnormal long bone hypertrophic chondrocyte zone 0.0277179265792966 0.12139078129387 0.772149392055131 0.571428571428571 5.6 5 6 increased fluid intake 0.0277179265792966 0.12139078129387 0.772149392055131 0.571428571428571 5.6 5 6 abnormal cartilage morphology 0.039912916657923 0.155130281541536 0.772149392055131 0.571428571428571 5.6 5 6 reddish skin 0.08554701536423 0.255000839686665 0.772149392055131 0.571428571428571 5.6 5 6 corneal vascularization 0.08554701536423 0.255000839686665 0.772149392055131 0.571428571428571 5.6 5 6 abnormal salivary gland morphology 0.12875741831296 0.346257483157758 0.772149392055131 0.571428571428571 5.6 5 6 abnormal blood flow velocity 0.200924912712315 0.437489008524116 0.772149392055131 0.571428571428571 5.6 5 6 abnormal zigzag hair morphology 0.200924912712315 0.437489008524116 0.772149392055131 0.571428571428571 5.6 5 6 abnormal olfactory system physiology 0.200924912712315 0.437489008524116 0.772149392055131 0.571428571428571 5.6 5 6 absent otoliths 0.200924912712315 0.437489008524116 0.772149392055131 0.571428571428571 5.6 5 6 abnormal prepulse inhibition 0.200924912712315 0.437489008524116 0.772149392055131 0.571428571428571 5.6 5 6 intestinal obstruction 0.200924912712315 0.437489008524116 0.772149392055131 0.571428571428571 5.6 5 6 abnormal ventral body wall morphology 0.200924912712315 0.437489008524116 0.772149392055131 0.571428571428571 5.6 5 6 abnormal vascular endothelial cell migration 0.200924912712315 0.437489008524116 0.772149392055131 0.571428571428571 5.6 5 6 abnormal imprinting 0.200924912712315 0.437489008524116 0.772149392055131 0.571428571428571 5.6 5 6 abnormal decidualization 0.200924912712315 0.437489008524116 0.772149392055131 0.571428571428571 5.6 5 6 split sternum 0.200924912712315 0.437489008524116 0.772149392055131 0.571428571428571 5.6 5 6 abnormal squamosal bone morphology 0.200924912712315 0.437489008524116 0.772149392055131 0.571428571428571 5.6 5 6 premature hair loss 0.200924912712315 0.437489008524116 0.772149392055131 0.571428571428571 5.6 5 6 increased circulating growth hormone level 0.200924912712315 0.437489008524116 0.772149392055131 0.571428571428571 5.6 5 6 increased stomach tumor incidence 0.200924912712315 0.437489008524116 0.772149392055131 0.571428571428571 5.6 5 6 abnormal respiratory motile cilium physiology 0.200924912712315 0.437489008524116 0.772149392055131 0.571428571428571 5.6 5 6 decreased T cell number 0.000129101326317104 0.00160465001930128 0.772149392055131 0.571428571428571 5.6 5 6 increased T cell proliferation 0.00176719037294439 0.0146042726003294 0.770345304690516 0.570093457943925 5.6 5 6 abnormal myelopoiesis 0.0394720830410148 0.154018520101214 0.767762179600272 0.568181818181818 5.6 5 6 abnormal photoreceptor outer segment morphology 0.0394720830410148 0.154018520101214 0.767762179600272 0.568181818181818 5.6 5 6 decreased T cell proliferation 0.000334717972445947 0.00370873477264719 0.766932166433137 0.567567567567568 5.6 5 6 increased brown adipose tissue amount 0.0572872813157179 0.201274169876904 0.766932166433137 0.567567567567568 5.6 5 6 abnormal pancreatic beta cell physiology 0.0572872813157179 0.201274169876904 0.766932166433137 0.567567567567568 5.6 5 6 abnormal hair follicle development 0.0572872813157179 0.201274169876904 0.766932166433137 0.567567567567568 5.6 5 6 decreased IgM level 0.0033976920878157 0.0241478830526902 0.766179164796973 0.56701030927835 5.6 5 6 abnormal eye physiology 0.019027766046114 0.0907604372765263 0.765714813788005 0.566666666666667 5.6 5 6 delayed eyelid opening 0.0842085246081192 0.25267636304306 0.765714813788005 0.566666666666667 5.6 5 6 abnormal microglial cell physiology 0.0842085246081192 0.25267636304306 0.765714813788005 0.566666666666667 5.6 5 6 abnormal cellular respiration 0.0842085246081192 0.25267636304306 0.765714813788005 0.566666666666667 5.6 5 6 abnormal coat appearance 0.0132719153855766 0.0707581731933409 0.763756463880619 0.565217391304348 5.6 5 6 abnormal inner ear morphology 0.0389794012393778 0.152335051976359 0.763756463880619 0.565217391304348 5.6 5 6 conjunctivitis 0.126147845968874 0.341636109795944 0.763756463880619 0.565217391304348 5.6 5 6 abnormal cochlear ganglion morphology 0.126147845968874 0.341636109795944 0.763756463880619 0.565217391304348 5.6 5 6 increased B cell number 0.0016999512858264 0.0141189610133328 0.762250040874937 0.564102564102564 5.6 5 6 abnormal heart ventricle morphology 0.00930216001066607 0.0551588153195038 0.762250040874937 0.564102564102564 5.6 5 6 acanthosis 0.0564585905838753 0.200058039996282 0.762250040874937 0.564102564102564 5.6 5 6 impaired macrophage chemotaxis 0.0564585905838753 0.200058039996282 0.762250040874937 0.564102564102564 5.6 5 6 decreased eosinophil cell number 0.0185920157145778 0.0897449645691265 0.76008455780427 0.5625 5.6 5 6 abnormal lymphatic vessel morphology 0.0827451249336853 0.248735345344462 0.76008455780427 0.5625 5.6 5 6 increased dopamine level 0.0827451249336853 0.248735345344462 0.76008455780427 0.5625 5.6 5 6 abnormal diaphragm morphology 0.0827451249336853 0.248735345344462 0.76008455780427 0.5625 5.6 5 6 abnormal bone marrow cell number 0.195018034953865 0.437489008524116 0.76008455780427 0.5625 5.6 5 6 abnormal extraembryonic endoderm formation 0.195018034953865 0.437489008524116 0.76008455780427 0.5625 5.6 5 6 white spotting 0.195018034953865 0.437489008524116 0.76008455780427 0.5625 5.6 5 6 decreased cochlear coiling 0.195018034953865 0.437489008524116 0.76008455780427 0.5625 5.6 5 6 increased pancreatic beta cell number 0.195018034953865 0.437489008524116 0.76008455780427 0.5625 5.6 5 6 decreased aggression towards mice 0.195018034953865 0.437489008524116 0.76008455780427 0.5625 5.6 5 6 abnormal level of surface class II molecules 0.195018034953865 0.437489008524116 0.76008455780427 0.5625 5.6 5 6 sepsis 0.195018034953865 0.437489008524116 0.76008455780427 0.5625 5.6 5 6 loose skin 0.195018034953865 0.437489008524116 0.76008455780427 0.5625 5.6 5 6 decreased creatinine clearance 0.195018034953865 0.437489008524116 0.76008455780427 0.5625 5.6 5 6 increased heart left ventricle size 0.195018034953865 0.437489008524116 0.76008455780427 0.5625 5.6 5 6 dilated respiratory conducting tubes 0.195018034953865 0.437489008524116 0.76008455780427 0.5625 5.6 5 6 abnormal osteoclast morphology 0.0384441333240297 0.151073904650117 0.760084557804269 0.5625 5.6 5 6 absent vitelline blood vessels 0.0264584573220848 0.117737768494966 0.75860291149276 0.56140350877193 5.6 5 6 abnormal circulating amino acid level 0.0264584573220848 0.117737768494966 0.75860291149276 0.56140350877193 5.6 5 6 abnormal skin morphology 0.0183526970839549 0.0897449645691265 0.757525350538935 0.560606060606061 5.6 5 6 testicular atrophy 0.037874165510144 0.148951757638709 0.756706404214028 0.56 5.6 5 6 diaphragmatic hernia 0.123367315801936 0.334652342483441 0.756706404214028 0.56 5.6 5 6 decreased placenta weight 0.123367315801936 0.334652342483441 0.756706404214028 0.56 5.6 5 6 increased liver glycogen level 0.123367315801936 0.334652342483441 0.756706404214028 0.56 5.6 5 6 abnormal spleen red pulp morphology 0.0811907390176439 0.245744489846268 0.755116684877444 0.558823529411765 5.6 5 6 impaired fertilization 0.0178414369162436 0.0882317581096541 0.752845657253753 0.557142857142857 5.6 5 6 dehydration 0.0178414369162436 0.0882317581096541 0.752845657253753 0.557142857142857 5.6 5 6 abnormal response to infection 0.0124603933402679 0.0684706935924497 0.752601306180317 0.556962025316456 5.6 5 6 abnormal epidermis stratum granulosum morphology 0.0795718080217949 0.242270345721193 0.750700797831377 0.555555555555556 5.6 5 6 impaired wound healing 0.0795718080217949 0.242270345721193 0.750700797831377 0.555555555555556 5.6 5 6 abnormal mammary gland morphology 0.189046732840349 0.43083256797102 0.750700797831377 0.555555555555556 5.6 5 6 abnormal retinal rod cell morphology 0.189046732840349 0.43083256797102 0.750700797831377 0.555555555555556 5.6 5 6 thick dermal layer 0.189046732840349 0.43083256797102 0.750700797831377 0.555555555555556 5.6 5 6 blepharoptosis 0.189046732840349 0.43083256797102 0.750700797831377 0.555555555555556 5.6 5 6 abnormal iron level 0.189046732840349 0.43083256797102 0.750700797831377 0.555555555555556 5.6 5 6 eye inflammation 0.189046732840349 0.43083256797102 0.750700797831377 0.555555555555556 5.6 5 6 abnormal thymus medulla morphology 0.189046732840349 0.43083256797102 0.750700797831377 0.555555555555556 5.6 5 6 abnormal body wall morphology 0.189046732840349 0.43083256797102 0.750700797831377 0.555555555555556 5.6 5 6 long tibia 0.189046732840349 0.43083256797102 0.750700797831377 0.555555555555556 5.6 5 6 abnormal neutrophil morphology 0.189046732840349 0.43083256797102 0.750700797831377 0.555555555555556 5.6 5 6 abnormal glycogen homeostasis 0.189046732840349 0.43083256797102 0.750700797831377 0.555555555555556 5.6 5 6 abnormal pregnancy 0.189046732840349 0.43083256797102 0.750700797831377 0.555555555555556 5.6 5 6 decreased tumor latency 0.189046732840349 0.43083256797102 0.750700797831377 0.555555555555556 5.6 5 6 abnormal metanephric mesenchyme morphology 0.189046732840349 0.43083256797102 0.750700797831377 0.555555555555556 5.6 5 6 crypts of Lieberkuhn abscesses 0.321518491292824 0.610116928715209 0.750700797831377 0.555555555555556 5.6 5 6 renal tubular acidosis 0.321518491292824 0.610116928715209 0.750700797831377 0.555555555555556 5.6 5 6 absent parathyroid glands 0.321518491292824 0.610116928715209 0.750700797831377 0.555555555555556 5.6 5 6 abnormal sympathetic neuron morphology 0.321518491292824 0.610116928715209 0.750700797831377 0.555555555555556 5.6 5 6 abnormal cholinergic neuron morphology 0.321518491292824 0.610116928715209 0.750700797831377 0.555555555555556 5.6 5 6 absent enteric neurons 0.321518491292824 0.610116928715209 0.750700797831377 0.555555555555556 5.6 5 6 small geniculate ganglion 0.321518491292824 0.610116928715209 0.750700797831377 0.555555555555556 5.6 5 6 abnormal lens vesicle development 0.321518491292824 0.610116928715209 0.750700797831377 0.555555555555556 5.6 5 6 yellow coat color 0.321518491292824 0.610116928715209 0.750700797831377 0.555555555555556 5.6 5 6 enlarged otoliths 0.321518491292824 0.610116928715209 0.750700797831377 0.555555555555556 5.6 5 6 premature bone ossification 0.321518491292824 0.610116928715209 0.750700797831377 0.555555555555556 5.6 5 6 decreased susceptibility to induced choroidal neovascularization 0.321518491292824 0.610116928715209 0.750700797831377 0.555555555555556 5.6 5 6 abnormal proprioceptive neuron morphology 0.321518491292824 0.610116928715209 0.750700797831377 0.555555555555556 5.6 5 6 decreased cochlear hair cell number 0.321518491292824 0.610116928715209 0.750700797831377 0.555555555555556 5.6 5 6 abnormal hair cell mechanoelectric transduction 0.321518491292824 0.610116928715209 0.750700797831377 0.555555555555556 5.6 5 6 abnormal inguinal fat pad morphology 0.321518491292824 0.610116928715209 0.750700797831377 0.555555555555556 5.6 5 6 abnormal liver vasculature morphology 0.321518491292824 0.610116928715209 0.750700797831377 0.555555555555556 5.6 5 6 abnormal hyoid bone lesser horn morphology 0.321518491292824 0.610116928715209 0.750700797831377 0.555555555555556 5.6 5 6 iris coloboma 0.321518491292824 0.610116928715209 0.750700797831377 0.555555555555556 5.6 5 6 decreased susceptibility to parasitic infection induced morbidity/mortality 0.321518491292824 0.610116928715209 0.750700797831377 0.555555555555556 5.6 5 6 abnormal heart left ventricle pressure 0.321518491292824 0.610116928715209 0.750700797831377 0.555555555555556 5.6 5 6 abnormal pulmonary alveolar system morphology 0.321518491292824 0.610116928715209 0.750700797831377 0.555555555555556 5.6 5 6 abnormal ureteric bud invasion 0.321518491292824 0.610116928715209 0.750700797831377 0.555555555555556 5.6 5 6 decreased pancreatic beta cell proliferation 0.321518491292824 0.610116928715209 0.750700797831377 0.555555555555556 5.6 5 6 decreased bone trabecular spacing 0.321518491292824 0.610116928715209 0.750700797831377 0.555555555555556 5.6 5 6 decreased fatty acid oxidation 0.321518491292824 0.610116928715209 0.750700797831377 0.555555555555556 5.6 5 6 decreased bone mineral density of femur 0.321518491292824 0.610116928715209 0.750700797831377 0.555555555555556 5.6 5 6 increased bone mineralization 0.321518491292824 0.610116928715209 0.750700797831377 0.555555555555556 5.6 5 6 adipose tissue inflammation 0.321518491292824 0.610116928715209 0.750700797831377 0.555555555555556 5.6 5 6 abnormal long bone epiphyseal plate proliferative zone 0.0366560779925323 0.145309950607847 0.750700797831377 0.555555555555556 5.6 5 6 abnormal osteoblast physiology 0.0366560779925323 0.145309950607847 0.750700797831377 0.555555555555556 5.6 5 6 abnormal cartilage development 0.0536439006311537 0.192309931484681 0.750700797831377 0.555555555555556 5.6 5 6 albuminuria 0.0536439006311537 0.192309931484681 0.750700797831377 0.555555555555556 5.6 5 6 decreased bone ossification 0.120483026020871 0.333701507086192 0.750700797831377 0.555555555555556 5.6 5 6 decreased monocyte cell number 0.0248746980284097 0.11342953500581 0.748390949222665 0.553846153846154 5.6 5 6 maternal effect 0.0244517638541038 0.11160323410474 0.746219002023429 0.552238805970149 5.6 5 6 decreased retinal photoreceptor cell number 0.117542885547771 0.327055847651095 0.745523550949782 0.551724137931034 5.6 5 6 abnormal CD8-positive, alpha-beta T cell physiology 0.117542885547771 0.327055847651095 0.745523550949782 0.551724137931034 5.6 5 6 enlarged epididymis 0.117542885547771 0.327055847651095 0.745523550949782 0.551724137931034 5.6 5 6 abnormal epidermis stratum corneum morphology 0.0516081143289293 0.192309931484681 0.744572628053162 0.551020408163265 5.6 5 6 abnormal skin pigmentation 0.0762189853088306 0.234486728353912 0.743193789853064 0.55 5.6 5 6 abnormal pericardium morphology 0.183121339969817 0.420216174515608 0.743193789853064 0.55 5.6 5 6 abnormal dopamine level 0.183121339969817 0.420216174515608 0.743193789853064 0.55 5.6 5 6 abnormal hair texture 0.183121339969817 0.420216174515608 0.743193789853064 0.55 5.6 5 6 decreased skin tensile strength 0.183121339969817 0.420216174515608 0.743193789853064 0.55 5.6 5 6 absent placental labyrinth 0.183121339969817 0.420216174515608 0.743193789853064 0.55 5.6 5 6 kidney atrophy 0.183121339969817 0.420216174515608 0.743193789853064 0.55 5.6 5 6 impaired hematopoiesis 0.0505671503144013 0.189151558506877 0.741869023739243 0.549019607843137 5.6 5 6 decreased double-negative T cell number 0.114581461023051 0.319351691086653 0.741014335923876 0.548387096774194 5.6 5 6 abnormal T cell proliferation 0.114581461023051 0.319351691086653 0.741014335923876 0.548387096774194 5.6 5 6 abnormal podocyte morphology 0.114581461023051 0.319351691086653 0.741014335923876 0.548387096774194 5.6 5 6 alopecia 0.010934275774929 0.062742816586242 0.739637838705441 0.547368421052632 5.6 5 6 improved glucose tolerance 0.000432294231213634 0.0046052758036142 0.73767843705267 0.545918367346939 5.6 5 6 decreased systemic arterial blood pressure 0.111623896837149 0.311807347986984 0.737051692416261 0.545454545454545 5.6 5 6 decreased sensitivity to xenobiotic induced morbidity/mortality 0.111623896837149 0.311807347986984 0.737051692416261 0.545454545454545 5.6 5 6 abnormal basisphenoid bone morphology 0.177304915080399 0.416215504368312 0.737051692416261 0.545454545454545 5.6 5 6 abnormal long bone epiphysis morphology 0.177304915080399 0.416215504368312 0.737051692416261 0.545454545454545 5.6 5 6 abnormal oogenesis 0.177304915080399 0.416215504368312 0.737051692416261 0.545454545454545 5.6 5 6 abnormal female reproductive system physiology 0.177304915080399 0.416215504368312 0.737051692416261 0.545454545454545 5.6 5 6 abnormal retinal outer plexiform layer morphology 0.177304915080399 0.416215504368312 0.737051692416261 0.545454545454545 5.6 5 6 abnormal mesenteric lymph node morphology 0.177304915080399 0.416215504368312 0.737051692416261 0.545454545454545 5.6 5 6 increased bone volume 0.177304915080399 0.416215504368312 0.737051692416261 0.545454545454545 5.6 5 6 abnormal awl hair morphology 0.30509111653101 0.603030713047985 0.737051692416261 0.545454545454545 5.6 5 6 abnormal primary sex determination 0.30509111653101 0.603030713047985 0.737051692416261 0.545454545454545 5.6 5 6 abnormal larynx morphology 0.30509111653101 0.603030713047985 0.737051692416261 0.545454545454545 5.6 5 6 abnormal bronchiole morphology 0.30509111653101 0.603030713047985 0.737051692416261 0.545454545454545 5.6 5 6 allodynia 0.30509111653101 0.603030713047985 0.737051692416261 0.545454545454545 5.6 5 6 abnormal hair medulla 0.30509111653101 0.603030713047985 0.737051692416261 0.545454545454545 5.6 5 6 abnormal crista ampullaris neuroepithelium morphology 0.30509111653101 0.603030713047985 0.737051692416261 0.545454545454545 5.6 5 6 cyclopia 0.30509111653101 0.603030713047985 0.737051692416261 0.545454545454545 5.6 5 6 abnormal Bruch membrane morphology 0.30509111653101 0.603030713047985 0.737051692416261 0.545454545454545 5.6 5 6 abnormal palate development 0.30509111653101 0.603030713047985 0.737051692416261 0.545454545454545 5.6 5 6 enhanced behavioral response to addictive substance 0.30509111653101 0.603030713047985 0.737051692416261 0.545454545454545 5.6 5 6 abnormal extraembryonic ectoderm morphology 0.30509111653101 0.603030713047985 0.737051692416261 0.545454545454545 5.6 5 6 increased leukocyte cell number 0.00243370958954519 0.0189287452437854 0.736204506562909 0.544827586206897 5.6 5 6 increased macrophage cell number 0.0474173308205214 0.178848537401133 0.734896570508611 0.543859649122807 5.6 5 6 abnormal forelimb morphology 0.0711016380023156 0.234486728353912 0.734381215269826 0.543478260869565 5.6 5 6 impaired adaptive thermogenesis 0.108688565334568 0.303949191983965 0.733541922452374 0.542857142857143 5.6 5 6 abnormal urine homeostasis 0.0141249409750307 0.0717789390712745 0.731933277885593 0.541666666666667 5.6 5 6 abnormal lymph node morphology 0.0694080980873948 0.232372333771729 0.731933277885593 0.541666666666667 5.6 5 6 decreased metastatic potential 0.171633356160771 0.416215504368312 0.731933277885593 0.541666666666667 5.6 5 6 decreased IgG level 0.00938377716920506 0.0555765374009466 0.730411587079178 0.540540540540541 5.6 5 6 increased circulating phosphate level 0.105788898264238 0.301955960613896 0.730411587079178 0.540540540540541 5.6 5 6 abnormal circulating protein level 0.0677305759857644 0.227214845265798 0.729681175492099 0.54 5.6 5 6 increased urine protein level 0.0287400160549669 0.124115954751268 0.727602311744258 0.538461538461538 5.6 5 6 small lens 0.102934676879087 0.299473694428922 0.727602311744258 0.538461538461538 5.6 5 6 abnormal stomach morphology 0.16612638021464 0.416215504368312 0.727602311744258 0.538461538461538 5.6 5 6 decreased Peyer's patch number 0.16612638021464 0.416215504368312 0.727602311744258 0.538461538461538 5.6 5 6 absent myocardial trabeculae 0.290367662426467 0.577369752426728 0.727602311744258 0.538461538461538 5.6 5 6 absent trabeculae carneae 0.290367662426467 0.577369752426728 0.727602311744258 0.538461538461538 5.6 5 6 uterus hypoplasia 0.290367662426467 0.577369752426728 0.727602311744258 0.538461538461538 5.6 5 6 abnormal intercostal muscle morphology 0.290367662426467 0.577369752426728 0.727602311744258 0.538461538461538 5.6 5 6 small pituitary gland 0.290367662426467 0.577369752426728 0.727602311744258 0.538461538461538 5.6 5 6 increased renin activity 0.290367662426467 0.577369752426728 0.727602311744258 0.538461538461538 5.6 5 6 abnormal aorta tunica media morphology 0.290367662426467 0.577369752426728 0.727602311744258 0.538461538461538 5.6 5 6 abnormal hair follicle inner root sheath morphology 0.290367662426467 0.577369752426728 0.727602311744258 0.538461538461538 5.6 5 6 abnormal femur morphology 0.0422809724222536 0.162682009126614 0.72605092088766 0.537313432835821 5.6 5 6 polyphagia 0.0644393265864549 0.222320145469912 0.725677437903665 0.537037037037037 5.6 5 6 increased bone trabecula number 0.10013295609788 0.291834479547132 0.725067112051769 0.536585365853659 5.6 5 6 abnormal epidermal layer morphology 0.0412900301407996 0.158992182624209 0.724589465732895 0.536231884057971 5.6 5 6 increased lymphocyte cell number 0.0412900301407996 0.158992182624209 0.724589465732895 0.536231884057971 5.6 5 6 abnormal circulating cholesterol level 0.160793807547764 0.411920284526327 0.723890055051685 0.535714285714286 5.6 5 6 decreased oxygen consumption 0.0973887364113419 0.284169480144531 0.722767744888814 0.534883720930233 5.6 5 6 liver inflammation 0.0109307628116119 0.062742816586242 0.720672765918122 0.533333333333333 5.6 5 6 abnormal long bone epiphyseal plate morphology 0.0597011924439918 0.206124571746635 0.720672765918122 0.533333333333333 5.6 5 6 abnormal spleen marginal zone morphology 0.155639298050229 0.399126550412314 0.720672765918122 0.533333333333333 5.6 5 6 decreased salivation 0.277000046515193 0.552999691578284 0.720672765918122 0.533333333333333 5.6 5 6 hyperpigmentation 0.277000046515193 0.552999691578284 0.720672765918122 0.533333333333333 5.6 5 6 abnormal epidermis stratum spinosum morphology 0.277000046515193 0.552999691578284 0.720672765918122 0.533333333333333 5.6 5 6 abnormal apical ectodermal ridge morphology 0.277000046515193 0.552999691578284 0.720672765918122 0.533333333333333 5.6 5 6 increased airway responsiveness 0.277000046515193 0.552999691578284 0.720672765918122 0.533333333333333 5.6 5 6 abnormal ear development 0.277000046515193 0.552999691578284 0.720672765918122 0.533333333333333 5.6 5 6 abnormal energy homeostasis 0.277000046515193 0.552999691578284 0.720672765918122 0.533333333333333 5.6 5 6 abnormal aorta wall morphology 0.277000046515193 0.552999691578284 0.720672765918122 0.533333333333333 5.6 5 6 decreased trabecular bone mass 0.277000046515193 0.552999691578284 0.720672765918122 0.533333333333333 5.6 5 6 abnormal vertebral body morphology 0.150662641924331 0.386563508805337 0.717857637926255 0.53125 5.6 5 6 decreased neutrophil cell number 0.0143548118513912 0.0728726417966031 0.716053068700698 0.52991452991453 5.6 5 6 abnormal skin physiology 0.145861199384093 0.37443728944059 0.715373701462842 0.529411764705882 5.6 5 6 increased regulatory T cell number 0.264746748337984 0.531094787492528 0.715373701462842 0.529411764705882 5.6 5 6 abnormal thrombosis 0.0870394298660479 0.258013544534433 0.715373701462842 0.529411764705882 5.6 5 6 abnormal heart left ventricle morphology 0.0510614428291398 0.190857008320789 0.713165757939808 0.527777777777778 5.6 5 6 decreased threshold for auditory brainstem response 0.136766460834618 0.351271627595367 0.711190229524463 0.526315789473684 5.6 5 6 delayed sexual maturation 0.253431710334621 0.509012014095576 0.711190229524463 0.526315789473684 5.6 5 6 abnormal ear morphology 0.253431710334621 0.509012014095576 0.711190229524463 0.526315789473684 5.6 5 6 abnormal metatarsal bone morphology 0.253431710334621 0.509012014095576 0.711190229524463 0.526315789473684 5.6 5 6 abnormal digestive system development 0.253431710334621 0.509012014095576 0.711190229524463 0.526315789473684 5.6 5 6 impaired ovarian folliculogenesis 0.132462546509369 0.346257483157758 0.709412253950652 0.525 5.6 5 6 increased osteoclast cell number 0.075555685869661 0.234486728353912 0.70885845828012 0.524590163934426 5.6 5 6 small ears 0.242921653792359 0.489285517253841 0.70780360938387 0.523809523809524 5.6 5 6 dry skin 0.242921653792359 0.489285517253841 0.70780360938387 0.523809523809524 5.6 5 6 abnormal clavicle morphology 0.242921653792359 0.489285517253841 0.70780360938387 0.523809523809524 5.6 5 6 increased bone ossification 0.242921653792359 0.489285517253841 0.70780360938387 0.523809523809524 5.6 5 6 osteoporosis 0.124312728389174 0.337033146450212 0.70634120523225 0.522727272727273 5.6 5 6 decreased compact bone thickness 0.069407091916203 0.232372333771729 0.705882839751892 0.522388059701492 5.6 5 6 abnormal lymphocyte physiology 0.120455081565831 0.333701507086192 0.705005966659033 0.521739130434783 5.6 5 6 hypotension 0.233112626838427 0.47067180134788 0.705005966659033 0.521739130434783 5.6 5 6 failure of embryo implantation 0.233112626838427 0.47067180134788 0.705005966659033 0.521739130434783 5.6 5 6 decreased epididymis weight 0.233112626838427 0.47067180134788 0.705005966659033 0.521739130434783 5.6 5 6 abnormal ulna morphology 0.233112626838427 0.47067180134788 0.705005966659033 0.521739130434783 5.6 5 6 abnormal palatal shelf fusion at midline 0.233112626838427 0.47067180134788 0.705005966659033 0.521739130434783 5.6 5 6 kidney inflammation 0.113145665302576 0.315880855712859 0.702655946770169 0.52 5.6 5 6 increased pre-B cell number 0.223921566549508 0.45303366961521 0.702655946770169 0.52 5.6 5 6 abnormal keratinocyte physiology 0.223921566549508 0.45303366961521 0.702655946770169 0.52 5.6 5 6 cryptorchism 0.215280761654083 0.437489008524116 0.700654077975952 0.518518518518518 5.6 5 6 glomerulosclerosis 0.10000110185994 0.291621032680656 0.69892832901542 0.517241379310345 5.6 5 6 abnormal microglial cell morphology 0.207134081119187 0.437489008524116 0.69892832901542 0.517241379310345 5.6 5 6 increased retinal apoptosis 0.207134081119187 0.437489008524116 0.69892832901542 0.517241379310345 5.6 5 6 absent mature ovarian follicles 0.199434324212553 0.437489008524116 0.697425257340118 0.516129032258065 5.6 5 6 increased inflammatory response 0.0468790942354588 0.176952574978306 0.696966424933973 0.515789473684211 5.6 5 6 abnormal osteoclast physiology 0.0912812650958847 0.266818033990615 0.696744177987247 0.515625 5.6 5 6 abnormal tooth morphology 0.0912812650958847 0.266818033990615 0.696744177987247 0.515625 5.6 5 6 absent vibrissae 0.192141308579462 0.437484215186647 0.696104376170913 0.515151515151515 5.6 5 6 decreased bone volume 0.185220458965944 0.424837152307779 0.694934452849618 0.514285714285714 5.6 5 6 increased white adipose tissue amount 0.178641744597951 0.416215504368312 0.693891007725219 0.513513513513513 5.6 5 6 abnormal cytokine secretion 0.017245872541886 0.0856269619719391 0.693179567867674 0.512987012987013 5.6 5 6 abnormal lens fiber morphology 0.172378864998335 0.416215504368312 0.692954582613579 0.512820512820513 5.6 5 6 increased tumor growth/size 0.166408616441433 0.416215504368312 0.692109516049416 0.51219512195122 5.6 5 6 increased food intake 0.0678376247351936 0.227420608529372 0.691717163716055 0.511904761904762 5.6 5 6 abnormal blood circulation 0.160710392124303 0.411918702121797 0.691343060328431 0.511627906976744 5.6 5 6 abnormal T-helper 2 physiology 0.131320396230752 0.346257483157758 0.687914912921844 0.509090909090909 5.6 5 6 abnormal CD4-positive, alpha-beta T cell physiology 0.101736882223686 0.296162076689781 0.685146643654553 0.507042253521127 5.6 5 6 abnormal T cell differentiation 0.0647762713219619 0.223327754557699 0.682320131098222 0.504950495049505 5.6 5 6 increased liver weight 0.0953787390956451 0.278467856221147 0.67563071804824 0.5 5.6 5 6 abnormal inflammatory response 0.122513286947143 0.333701507086192 0.67563071804824 0.5 5.6 5 6 abnormal spleen white pulp morphology 0.204503966937287 0.437489008524116 0.67563071804824 0.5 5.6 5 6 decreased macrophage cell number 0.197108055859433 0.437489008524116 0.67563071804824 0.5 5.6 5 6 abnormal enterocyte morphology 0.30853839250432 0.608876835664018 0.67563071804824 0.5 5.6 5 6 abnormal circulating lipid level 0.30853839250432 0.608876835664018 0.67563071804824 0.5 5.6 5 6 failure of palatal shelf elevation 0.30853839250432 0.608876835664018 0.67563071804824 0.5 5.6 5 6 rough coat 0.30853839250432 0.608876835664018 0.67563071804824 0.5 5.6 5 6 abnormal megakaryocyte differentiation 0.340446763835618 0.610116928715209 0.67563071804824 0.5 5.6 5 6 decreased mast cell number 0.35898205807652 0.610116928715209 0.67563071804824 0.5 5.6 5 6 delayed hair appearance 0.35898205807652 0.610116928715209 0.67563071804824 0.5 5.6 5 6 cortical renal glomerulopathies 0.340446763835618 0.610116928715209 0.67563071804824 0.5 5.6 5 6 abnormal meiosis 0.35898205807652 0.610116928715209 0.67563071804824 0.5 5.6 5 6 abnormal fibula morphology 0.323742080699425 0.610116928715209 0.67563071804824 0.5 5.6 5 6 abnormal Peyer's patch follicle morphology 0.340446763835618 0.610116928715209 0.67563071804824 0.5 5.6 5 6 abnormal molar crown morphology 0.35898205807652 0.610116928715209 0.67563071804824 0.5 5.6 5 6 small epididymis 0.35898205807652 0.610116928715209 0.67563071804824 0.5 5.6 5 6 jerky movement 0.340446763835618 0.610116928715209 0.67563071804824 0.5 5.6 5 6 kidney degeneration 0.35898205807652 0.610116928715209 0.67563071804824 0.5 5.6 5 6 decreased fluid intake 0.340446763835618 0.610116928715209 0.67563071804824 0.5 5.6 5 6 absent palatine bone horizontal plate 0.431447060288905 0.615028402560831 0.67563071804824 0.5 5.6 5 6 kidney hemorrhage 0.431447060288905 0.615028402560831 0.67563071804824 0.5 5.6 5 6 abnormal bone healing 0.431447060288905 0.615028402560831 0.67563071804824 0.5 5.6 5 6 abnormal scala media morphology 0.431447060288905 0.615028402560831 0.67563071804824 0.5 5.6 5 6 aneurysm 0.431447060288905 0.615028402560831 0.67563071804824 0.5 5.6 5 6 abnormal glial cell physiology 0.431447060288905 0.615028402560831 0.67563071804824 0.5 5.6 5 6 abnormal submandibular gland morphology 0.431447060288905 0.615028402560831 0.67563071804824 0.5 5.6 5 6 increased atrioventricular cushion size 0.431447060288905 0.615028402560831 0.67563071804824 0.5 5.6 5 6 increased defecation amount 0.431447060288905 0.615028402560831 0.67563071804824 0.5 5.6 5 6 abnormal reproductive system development 0.431447060288905 0.615028402560831 0.67563071804824 0.5 5.6 5 6 abnormal utricular macula morphology 0.431447060288905 0.615028402560831 0.67563071804824 0.5 5.6 5 6 abnormal respiratory conducting tube morphology 0.431447060288905 0.615028402560831 0.67563071804824 0.5 5.6 5 6 abnormal cochlear inner hair cell physiology 0.431447060288905 0.615028402560831 0.67563071804824 0.5 5.6 5 6 ascites 0.431447060288905 0.615028402560831 0.67563071804824 0.5 5.6 5 6 increased susceptibility to atherosclerosis 0.431447060288905 0.615028402560831 0.67563071804824 0.5 5.6 5 6 increased platelet aggregation 0.431447060288905 0.615028402560831 0.67563071804824 0.5 5.6 5 6 absent inguinal lymph nodes 0.431447060288905 0.615028402560831 0.67563071804824 0.5 5.6 5 6 absent axillary lymph nodes 0.431447060288905 0.615028402560831 0.67563071804824 0.5 5.6 5 6 crystalluria 0.431447060288905 0.615028402560831 0.67563071804824 0.5 5.6 5 6 increased T-helper 17 cell number 0.431447060288905 0.615028402560831 0.67563071804824 0.5 5.6 5 6 abnormal leukocyte migration 0.1709093701482 0.416215504368312 0.675630718048239 0.5 5.6 5 6 gastrointestinal hemorrhage 0.258628864188146 0.519031302676897 0.675630718048239 0.5 5.6 5 6 increased metastatic potential 0.258628864188146 0.519031302676897 0.675630718048239 0.5 5.6 5 6 abnormal stria vascularis morphology 0.269767715760401 0.540716225022564 0.675630718048239 0.5 5.6 5 6 small seminal vesicle 0.281716752884376 0.561965054370397 0.675630718048239 0.5 5.6 5 6 hypopigmentation 0.294591897516084 0.585301393826884 0.675630718048239 0.5 5.6 5 6 absent atrioventricular cushions 0.37981041214062 0.610116928715209 0.675630718048239 0.5 5.6 5 6 absent optic nerve 0.40361159316741 0.610116928715209 0.675630718048239 0.5 5.6 5 6 increased aggression towards males 0.37981041214062 0.610116928715209 0.675630718048239 0.5 5.6 5 6 absent visceral yolk sac blood islands 0.37981041214062 0.610116928715209 0.675630718048239 0.5 5.6 5 6 abnormal antigen presentation 0.37981041214062 0.610116928715209 0.675630718048239 0.5 5.6 5 6 ear inflammation 0.40361159316741 0.610116928715209 0.675630718048239 0.5 5.6 5 6 interstitial pneumonia 0.40361159316741 0.610116928715209 0.675630718048239 0.5 5.6 5 6 increased papilloma incidence 0.40361159316741 0.610116928715209 0.675630718048239 0.5 5.6 5 6 abnormal aorta elastic fiber morphology 0.40361159316741 0.610116928715209 0.675630718048239 0.5 5.6 5 6 decreased circulating ketone body level 0.40361159316741 0.610116928715209 0.675630718048239 0.5 5.6 5 6 increased hepatocyte proliferation 0.40361159316741 0.610116928715209 0.675630718048239 0.5 5.6 5 6 abnormal pancreas development 0.37981041214062 0.610116928715209 0.675630718048239 0.5 5.6 5 6 pale placenta 0.40361159316741 0.610116928715209 0.675630718048239 0.5 5.6 5 6 vestibular saccular macula degeneration 0.40361159316741 0.610116928715209 0.675630718048239 0.5 5.6 5 6 absent cochlear hair cells 0.40361159316741 0.610116928715209 0.675630718048239 0.5 5.6 5 6 small parietal bone 0.40361159316741 0.610116928715209 0.675630718048239 0.5 5.6 5 6 abnormal positive T cell selection 0.37981041214062 0.610116928715209 0.675630718048239 0.5 5.6 5 6 hematuria 0.40361159316741 0.610116928715209 0.675630718048239 0.5 5.6 5 6 abnormal anogenital distance 0.40361159316741 0.610116928715209 0.675630718048239 0.5 5.6 5 6 abnormal glucose tolerance 0.37981041214062 0.610116928715209 0.675630718048239 0.5 5.6 5 6 abnormal patella morphology 0.40361159316741 0.610116928715209 0.675630718048239 0.5 5.6 5 6 decreased renal glomerular filtration rate 0.40361159316741 0.610116928715209 0.675630718048239 0.5 5.6 5 6 decreased keratinocyte proliferation 0.40361159316741 0.610116928715209 0.675630718048239 0.5 5.6 5 6 hydrometra 0.40361159316741 0.610116928715209 0.675630718048239 0.5 5.6 5 6 impaired behavioral response to cocaine 0.40361159316741 0.610116928715209 0.675630718048239 0.5 5.6 5 6 abnormal aorta elastic tissue morphology 0.40361159316741 0.610116928715209 0.675630718048239 0.5 5.6 5 6 abnormal colon goblet cell morphology 0.40361159316741 0.610116928715209 0.675630718048239 0.5 5.6 5 6 abnormal humoral immune response 0.0885416924820914 0.259114658881415 0.669196139781113 0.495238095238095 5.6 5 6 increased double-negative T cell number 0.178079336260027 0.416215504368312 0.664554804637613 0.491803278688525 5.6 5 6 abnormal male meiosis 0.178079336260027 0.416215504368312 0.664554804637613 0.491803278688525 5.6 5 6 decreased susceptibility to induced arthritis 0.190832627593761 0.434703444266923 0.663777547556165 0.491228070175439 5.6 5 6 decreased urine osmolality 0.220158598907824 0.445783080816616 0.661842336047255 0.489795918367347 5.6 5 6 decreased osteoclast cell number 0.237131099539722 0.478591164385442 0.660616702091612 0.488888888888889 5.6 5 6 impaired macrophage phagocytosis 0.246306924713317 0.49570264985791 0.659918375768048 0.488372093023256 5.6 5 6 abnormal trabecular bone morphology 0.100751453701462 0.293465153492257 0.658598010870553 0.487394957983193 5.6 5 6 increased vascular permeability 0.266248283556085 0.533891660899444 0.6583068534829 0.487179487179487 5.6 5 6 abnormal long bone metaphysis morphology 0.277116952154374 0.553011166052149 0.65737042837126 0.486486486486487 5.6 5 6 pale kidney 0.314123745415265 0.610116928715209 0.653836178756361 0.483870967741935 5.6 5 6 abnormal CD8-positive, alpha beta T cell morphology 0.314123745415265 0.610116928715209 0.653836178756361 0.483870967741935 5.6 5 6 increased neutrophil cell number 0.0941243009548504 0.274966762918603 0.652333107081059 0.482758620689655 5.6 5 6 decreased granulocyte number 0.328225774758868 0.610116928715209 0.652333107081059 0.482758620689655 5.6 5 6 focal hair loss 0.328225774758868 0.610116928715209 0.652333107081059 0.482758620689655 5.6 5 6 abnormal small intestine morphology 0.241672425772135 0.487558928717102 0.650607358120527 0.481481481481481 5.6 5 6 increased susceptibility to injury 0.250609968656051 0.504158752148747 0.64964492120023 0.480769230769231 5.6 5 6 decreased acute inflammation 0.359826049177539 0.610116928715209 0.64860548932631 0.48 5.6 5 6 abnormal intestinal epithelium morphology 0.269869022458498 0.540716225022564 0.647479438129563 0.479166666666667 5.6 5 6 fragile skeleton 0.377678677698054 0.610116928715209 0.646255469437446 0.478260869565217 5.6 5 6 abnormal carpal bone morphology 0.377678677698054 0.610116928715209 0.646255469437446 0.478260869565217 5.6 5 6 abnormal retinal cone cell morphology 0.377678677698054 0.610116928715209 0.646255469437446 0.478260869565217 5.6 5 6 bidirectional circling 0.377678677698054 0.610116928715209 0.646255469437446 0.478260869565217 5.6 5 6 increased susceptibility to age related obesity 0.377678677698054 0.610116928715209 0.646255469437446 0.478260869565217 5.6 5 6 abnormal crista ampullaris morphology 0.377678677698054 0.610116928715209 0.646255469437446 0.478260869565217 5.6 5 6 abnormal B cell morphology 0.377678677698054 0.610116928715209 0.646255469437446 0.478260869565217 5.6 5 6 abnormal lens development 0.377678677698054 0.610116928715209 0.646255469437446 0.478260869565217 5.6 5 6 abnormal hepatocyte physiology 0.377678677698054 0.610116928715209 0.646255469437446 0.478260869565217 5.6 5 6 abnormal gametogenesis 0.291227631058168 0.578848367764438 0.644920230864229 0.477272727272727 5.6 5 6 abnormal dendritic cell physiology 0.164037178385663 0.416215504368312 0.644059189167481 0.476635514018692 5.6 5 6 abnormal vibrissa morphology 0.302808229525256 0.60138560554417 0.643457826712609 0.476190476190476 5.6 5 6 abnormal hematopoietic system physiology 0.397215196069484 0.610116928715209 0.643457826712609 0.476190476190476 5.6 5 6 increased vasoconstriction 0.397215196069484 0.610116928715209 0.643457826712609 0.476190476190476 5.6 5 6 abnormal tumor vascularization 0.397215196069484 0.610116928715209 0.643457826712609 0.476190476190476 5.6 5 6 thin dermal layer 0.418760311986516 0.610116928715209 0.640071206572016 0.473684210526316 5.6 5 6 decreased liver regeneration 0.418760311986516 0.610116928715209 0.640071206572016 0.473684210526316 5.6 5 6 decreased liver glycogen level 0.418760311986516 0.610116928715209 0.640071206572016 0.473684210526316 5.6 5 6 head tilt 0.341864843904438 0.610116928715209 0.638095678156671 0.472222222222222 5.6 5 6 abnormal retinal photoreceptor morphology 0.356573992783945 0.610116928715209 0.635887734633637 0.470588235294118 5.6 5 6 decreased regulatory T cell number 0.356573992783945 0.610116928715209 0.635887734633637 0.470588235294118 5.6 5 6 decreased cytotoxic T cell cytolysis 0.356573992783945 0.610116928715209 0.635887734633637 0.470588235294118 5.6 5 6 abnormal tendon morphology 0.442746777844107 0.629872810916337 0.635887734633637 0.470588235294118 5.6 5 6 common atrium 0.442746777844107 0.629872810916337 0.635887734633637 0.470588235294118 5.6 5 6 abnormal electroretinogram waveform feature 0.442746777844107 0.629872810916337 0.635887734633637 0.470588235294118 5.6 5 6 vagina atresia 0.469769482062869 0.660012192392763 0.630588670178357 0.466666666666667 5.6 5 6 abnormal bronchus morphology 0.469769482062869 0.660012192392763 0.630588670178357 0.466666666666667 5.6 5 6 altered righting response 0.469769482062869 0.660012192392763 0.630588670178357 0.466666666666667 5.6 5 6 joint inflammation 0.469769482062869 0.660012192392763 0.630588670178357 0.466666666666667 5.6 5 6 greasy coat 0.469769482062869 0.660012192392763 0.630588670178357 0.466666666666667 5.6 5 6 abnormal microglial cell activation 0.469769482062869 0.660012192392763 0.630588670178357 0.466666666666667 5.6 5 6 abnormal spleen germinal center morphology 0.407228303190995 0.610116928715209 0.627371381044794 0.464285714285714 5.6 5 6 increased sensitivity to induced morbidity/mortality 0.175134413676947 0.416215504368312 0.624224032979352 0.46195652173913 5.6 5 6 abnormal leukocyte cell number 0.426776874571678 0.611877507491095 0.623659124352221 0.461538461538462 5.6 5 6 abnormal kidney cortex morphology 0.426776874571678 0.611877507491095 0.623659124352221 0.461538461538462 5.6 5 6 abnormal mast cell morphology 0.50067781951679 0.69878067462272 0.623659124352221 0.461538461538462 5.6 5 6 increased pituitary adenoma incidence 0.50067781951679 0.69878067462272 0.623659124352221 0.461538461538462 5.6 5 6 abnormal otolith morphology 0.50067781951679 0.69878067462272 0.623659124352221 0.461538461538462 5.6 5 6 anal atresia 0.50067781951679 0.69878067462272 0.623659124352221 0.461538461538462 5.6 5 6 small otic vesicle 0.50067781951679 0.69878067462272 0.623659124352221 0.461538461538462 5.6 5 6 vestibular hair cell degeneration 0.50067781951679 0.69878067462272 0.623659124352221 0.461538461538462 5.6 5 6 abnormal leukocyte adhesion 0.381035683578502 0.610116928715209 0.623659124352221 0.461538461538462 5.6 5 6 abnormal immune system physiology 0.246097975745018 0.495482569539241 0.621144369818543 0.459677419354839 5.6 5 6 increased insulin secretion 0.396900551891991 0.610116928715209 0.620849849017301 0.459459459459459 5.6 5 6 skin inflammation 0.396900551891991 0.610116928715209 0.620849849017301 0.459459459459459 5.6 5 6 curly vibrissae 0.447982876313567 0.636957647802228 0.619328158210886 0.458333333333333 5.6 5 6 decreased ovulation rate 0.447982876313567 0.636957647802228 0.619328158210886 0.458333333333333 5.6 5 6 decreased bone mineralization 0.413759024382212 0.610116928715209 0.617719513644105 0.457142857142857 5.6 5 6 abnormal T cell subpopulation ratio 0.43171451889485 0.615233380550524 0.614209743680218 0.454545454545455 5.6 5 6 testis hypoplasia 0.471112532373788 0.661021375781269 0.614209743680218 0.454545454545455 5.6 5 6 abnormal tracheal cartilage morphology 0.471112532373788 0.661021375781269 0.614209743680218 0.454545454545455 5.6 5 6 abnormal retinal layer morphology 0.471112532373788 0.661021375781269 0.614209743680218 0.454545454545455 5.6 5 6 impaired humoral immune response 0.471112532373788 0.661021375781269 0.614209743680218 0.454545454545455 5.6 5 6 enlarged cranium 0.536743680087151 0.734810073867247 0.614209743680218 0.454545454545455 5.6 5 6 abnormal hypothalamus secretion 0.536743680087151 0.734810073867247 0.614209743680218 0.454545454545455 5.6 5 6 vasculitis 0.536743680087151 0.734810073867247 0.614209743680218 0.454545454545455 5.6 5 6 retinal detachment 0.536743680087151 0.734810073867247 0.614209743680218 0.454545454545455 5.6 5 6 abnormal nerve fiber response 0.536743680087151 0.734810073867247 0.614209743680218 0.454545454545455 5.6 5 6 pathological neovascularization 0.536743680087151 0.734810073867247 0.614209743680218 0.454545454545455 5.6 5 6 abnormal pituitary gland development 0.536743680087151 0.734810073867247 0.614209743680218 0.454545454545455 5.6 5 6 enlarged placenta 0.536743680087151 0.734810073867247 0.614209743680218 0.454545454545455 5.6 5 6 abnormal aorta smooth muscle morphology 0.536743680087151 0.734810073867247 0.614209743680218 0.454545454545455 5.6 5 6 increased subcutaneous adipose tissue amount 0.536743680087151 0.734810073867247 0.614209743680218 0.454545454545455 5.6 5 6 decreased core body temperature 0.536743680087151 0.734810073867247 0.614209743680218 0.454545454545455 5.6 5 6 abnormal cytotoxic T cell physiology 0.418338511603673 0.610116928715209 0.611284935376979 0.452380952380952 5.6 5 6 increased eosinophil cell number 0.383478377357189 0.610116928715209 0.610247100172603 0.451612903225806 5.6 5 6 abnormal response/metabolism to endogenous compounds 0.356456357130435 0.610116928715209 0.609715526043533 0.451219512195122 5.6 5 6 increased susceptibility to weight loss 0.435013339390082 0.619756976937473 0.608067646243416 0.45 5.6 5 6 waved hair 0.496502501221409 0.695019680240999 0.608067646243416 0.45 5.6 5 6 abnormal Peyer's patch T cell area morphology 0.496502501221409 0.695019680240999 0.608067646243416 0.45 5.6 5 6 abnormal physiological neovascularization 0.496502501221409 0.695019680240999 0.608067646243416 0.45 5.6 5 6 abnormal thymocyte activation 0.496502501221409 0.695019680240999 0.608067646243416 0.45 5.6 5 6 lung inflammation 0.320883329129176 0.610116928715209 0.606080497072686 0.448529411764706 5.6 5 6 abnormal circulating glucose level 0.471417857542099 0.661021375781269 0.605737885146697 0.448275862068966 5.6 5 6 increased double-positive T cell number 0.471417857542099 0.661021375781269 0.605737885146697 0.448275862068966 5.6 5 6 increased systemic arterial blood pressure 0.437326987432091 0.622874824642042 0.603755109745235 0.446808510638298 5.6 5 6 abnormal T cell activation 0.402401977961951 0.610116928715209 0.602589559340322 0.445945945945946 5.6 5 6 altered response to myocardial infarction 0.453710212962207 0.644916659853423 0.600560638265102 0.444444444444444 5.6 5 6 abnormal systemic arterial blood pressure 0.471274368764431 0.661021375781269 0.600560638265102 0.444444444444444 5.6 5 6 decreased heart rate variability 0.524586789050898 0.720546459284433 0.600560638265102 0.444444444444444 5.6 5 6 increased susceptibility to autoimmune disorder 0.524586789050898 0.720546459284433 0.600560638265102 0.444444444444444 5.6 5 6 impaired leukocyte tethering or rolling 0.524586789050898 0.720546459284433 0.600560638265102 0.444444444444444 5.6 5 6 abnormal NK cell physiology 0.440228633142879 0.62682811960098 0.598099324173851 0.442622950819672 5.6 5 6 increased width of hypertrophic chondrocyte zone 0.491035986877143 0.688141981609518 0.596144751219035 0.441176470588235 5.6 5 6 abnormal feces composition 0.51724895477759 0.711253054178693 0.594555031882451 0.44 5.6 5 6 abnormal pituitary gland morphology 0.555937478496696 0.754780715859878 0.59117687829221 0.4375 5.6 5 6 abnormal intestinal absorption 0.555937478496696 0.754780715859878 0.59117687829221 0.4375 5.6 5 6 abnormal pulmonary elastic fiber morphology 0.555937478496696 0.754780715859878 0.59117687829221 0.4375 5.6 5 6 bowed tibia 0.555937478496696 0.754780715859878 0.59117687829221 0.4375 5.6 5 6 bowed radius 0.555937478496696 0.754780715859878 0.59117687829221 0.4375 5.6 5 6 abnormal wound healing 0.555937478496696 0.754780715859878 0.59117687829221 0.4375 5.6 5 6 abnormal hair shaft morphology 0.487144270081393 0.682880457496458 0.59117687829221 0.4375 5.6 5 6 abnormal immune system morphology 0.504616469452098 0.69878067462272 0.587504972215861 0.434782608695652 5.6 5 6 pancreas inflammation 0.542984728278198 0.743149662499047 0.587504972215861 0.434782608695652 5.6 5 6 arrested T cell differentiation 0.534349164509161 0.733752992943162 0.585546622308474 0.433333333333333 5.6 5 6 decreased sensitivity to induced morbidity/mortality 0.522866033250679 0.718778257922666 0.583499256496207 0.431818181818182 5.6 5 6 abnormal intestinal goblet cell morphology 0.548993708748343 0.751167134494776 0.579112044041348 0.428571428571429 5.6 5 6 decreased circulating progesterone level 0.558155684870033 0.754780715859878 0.579112044041348 0.428571428571429 5.6 5 6 hypoalgesia 0.570967980085353 0.758293032814904 0.579112044041348 0.428571428571429 5.6 5 6 abnormal bile salt homeostasis 0.570967980085353 0.758293032814904 0.579112044041348 0.428571428571429 5.6 5 6 abnormal interparietal bone morphology 0.591328375048917 0.779093926342257 0.579112044041348 0.428571428571429 5.6 5 6 abnormal fluid regulation 0.591328375048917 0.779093926342257 0.579112044041348 0.428571428571429 5.6 5 6 skeletal muscle necrosis 0.591328375048917 0.779093926342257 0.579112044041348 0.428571428571429 5.6 5 6 enlarged stomach 0.591328375048917 0.779093926342257 0.579112044041348 0.428571428571429 5.6 5 6 abnormal renal reabsorbtion 0.591328375048917 0.779093926342257 0.579112044041348 0.428571428571429 5.6 5 6 diarrhea 0.571194460020694 0.758391363384828 0.57326242743487 0.424242424242424 5.6 5 6 abnormal compact bone morphology 0.582710311066379 0.768961219510673 0.56895218361957 0.421052631578947 5.6 5 6 abnormal nail morphology 0.601551499643176 0.791934033004711 0.56895218361957 0.421052631578947 5.6 5 6 osteoarthritis 0.601551499643176 0.791934033004711 0.56895218361957 0.421052631578947 5.6 5 6 abnormal digestive system physiology 0.583885515782379 0.770307727663043 0.567529803160521 0.42 5.6 5 6 abnormal intestine physiology 0.594627233804188 0.783232853634057 0.566658021588846 0.419354838709677 5.6 5 6 abnormal osteoblast morphology 0.61084319396722 0.803741044693711 0.563025598373533 0.416666666666667 5.6 5 6 abnormal cellular extravasation 0.61084319396722 0.803741044693711 0.563025598373533 0.416666666666667 5.6 5 6 increased urine phosphate level 0.631838027886966 0.816445257810437 0.563025598373533 0.416666666666667 5.6 5 6 bowed ulna 0.631838027886966 0.816445257810437 0.563025598373533 0.416666666666667 5.6 5 6 abnormal B cell proliferation 0.631838027886966 0.816445257810437 0.563025598373533 0.416666666666667 5.6 5 6 decreased oligodendrocyte number 0.631838027886966 0.816445257810437 0.563025598373533 0.416666666666667 5.6 5 6 stomach inflammation 0.619382386513281 0.814545961645142 0.559142663212336 0.413793103448276 5.6 5 6 increased susceptibility to induced arthritis 0.619382386513281 0.814545961645142 0.559142663212336 0.413793103448276 5.6 5 6 enlarged sebaceous gland 0.635170968953508 0.816445257810437 0.556401767804433 0.411764705882353 5.6 5 6 nephrocalcinosis 0.635170968953508 0.816445257810437 0.556401767804433 0.411764705882353 5.6 5 6 abnormal duodenum morphology 0.635170968953508 0.816445257810437 0.556401767804433 0.411764705882353 5.6 5 6 increased susceptibility to viral infection induced morbidity/mortality 0.627305391221179 0.816445257810437 0.556401767804433 0.411764705882353 5.6 5 6 increased autoantibody level 0.634714073388152 0.816445257810437 0.554363666090863 0.41025641025641 5.6 5 6 increased activated T cell number 0.640098674654897 0.816445257810437 0.552788769312196 0.409090909090909 5.6 5 6 decreased susceptibility to viral infection induced morbidity/mortality 0.640098674654897 0.816445257810437 0.552788769312196 0.409090909090909 5.6 5 6 abnormal male reproductive system physiology 0.671584165257688 0.818303017917462 0.540504574438592 0.4 5.6 5 6 nuclear cataracts 0.671584165257688 0.818303017917462 0.540504574438592 0.4 5.6 5 6 abnormal respiratory system morphology 0.672367637039615 0.818856546945431 0.540504574438592 0.4 5.6 5 6 arthritis 0.672367637039615 0.818856546945431 0.540504574438592 0.4 5.6 5 6 salivary gland inflammation 0.676071201182695 0.822964087566407 0.540504574438592 0.4 5.6 5 6 abnormal pain threshold 0.676071201182695 0.822964087566407 0.540504574438592 0.4 5.6 5 6 decreased susceptibility to injury 0.722364688570832 0.863885655201896 0.536530276097131 0.397058823529412 5.6 5 6 abnormal intestinal mucosa morphology 0.707357696452237 0.847364444943385 0.534219637526515 0.395348837209302 5.6 5 6 decreased inflammatory response 0.761041313869374 0.900613828853505 0.530852707037903 0.392857142857143 5.6 5 6 increased circulating luteinizing hormone level 0.702106595524089 0.8453937935954 0.530852707037902 0.392857142857143 5.6 5 6 delayed wound healing 0.729249926449361 0.87151170739373 0.528754474994274 0.391304347826087 5.6 5 6 abnormal radius morphology 0.705542719800623 0.8453937935954 0.525490558481964 0.388888888888889 5.6 5 6 abnormal macrophage chemotaxis 0.705542719800623 0.8453937935954 0.525490558481964 0.388888888888889 5.6 5 6 increased susceptibility to bacterial infection induced morbidity/mortality 0.770929218729144 0.911881327431643 0.525490558481964 0.388888888888889 5.6 5 6 abnormal body temperature homeostasis 0.727509496369119 0.869829306521598 0.523068943005089 0.387096774193548 5.6 5 6 impaired natural killer cell mediated cytotoxicity 0.76782318852829 0.908423391897323 0.521539501651273 0.385964912280702 5.6 5 6 increased circulating adrenocorticotropin level 0.713813158118326 0.85386402059117 0.519715936960184 0.384615384615385 5.6 5 6 absent lateral semicircular canal 0.713813158118326 0.85386402059117 0.519715936960184 0.384615384615385 5.6 5 6 decreased alcohol consumption 0.713813158118326 0.85386402059117 0.519715936960184 0.384615384615385 5.6 5 6 abnormal vestibulocochlear ganglion morphology 0.713813158118326 0.85386402059117 0.519715936960184 0.384615384615385 5.6 5 6 increased circulating thyroid-stimulating hormone level 0.713813158118326 0.85386402059117 0.519715936960184 0.384615384615385 5.6 5 6 decreased luteinizing hormone level 0.713813158118326 0.85386402059117 0.519715936960184 0.384615384615385 5.6 5 6 abnormal tectorial membrane morphology 0.729266982488462 0.87151170739373 0.519715936960184 0.384615384615385 5.6 5 6 abnormal bone remodeling 0.750047114842612 0.889295613999522 0.51665878438983 0.382352941176471 5.6 5 6 large intestinal inflammation 0.742225732165367 0.880231946966079 0.50672303853618 0.375 5.6 5 6 abnormal epididymis epithelium morphology 0.742225732165367 0.880231946966079 0.50672303853618 0.375 5.6 5 6 decreased circulating prolactin level 0.742225732165367 0.880231946966079 0.50672303853618 0.375 5.6 5 6 abnormal pancreatic alpha cell morphology 0.742225732165367 0.880231946966079 0.50672303853618 0.375 5.6 5 6 abnormal intestinal lipid absorption 0.742225732165367 0.880231946966079 0.50672303853618 0.375 5.6 5 6 abnormal urinary bladder physiology 0.742225732165367 0.880231946966079 0.50672303853618 0.375 5.6 5 6 decreased susceptibility to parasitic infection 0.773326883345377 0.914499939301938 0.50672303853618 0.375 5.6 5 6 abnormal foregut morphology 0.757540593626394 0.897752370960293 0.50672303853618 0.375 5.6 5 6 abnormal vasodilation 0.757540593626394 0.897752370960293 0.50672303853618 0.375 5.6 5 6 abnormal estrous cycle 0.797001323749711 0.92512396274816 0.495462526568709 0.366666666666667 5.6 5 6 increased susceptibility to parasitic infection 0.891934516796923 0.993590286848341 0.495462526568709 0.366666666666667 5.6 5 6 intestinal ulcer 0.78687504225231 0.92512396274816 0.491367794944174 0.363636363636364 5.6 5 6 abnormal stomach mucosa morphology 0.804960041238569 0.92512396274816 0.486454116994732 0.36 5.6 5 6 abnormal spleen periarteriolar lymphoid sheath morphology 0.781860259823554 0.923712845552643 0.482593370034457 0.357142857142857 5.6 5 6 abnormal kidney medulla morphology 0.781860259823554 0.923712845552643 0.482593370034457 0.357142857142857 5.6 5 6 abnormal uterus development 0.781860259823554 0.923712845552643 0.482593370034457 0.357142857142857 5.6 5 6 increased B-1 B cell number 0.781860259823554 0.923712845552643 0.482593370034457 0.357142857142857 5.6 5 6 autoimmune response 0.835221828809038 0.950418252132882 0.479479864421331 0.354838709677419 5.6 5 6 brain inflammation 0.817153549311194 0.930922580220561 0.472941502633768 0.35 5.6 5 6 abnormal circulating cytokine level 0.817153549311194 0.930922580220561 0.472941502633768 0.35 5.6 5 6 abnormal crypts of Lieberkuhn morphology 0.867642990718574 0.98640856463092 0.464496118658165 0.34375 5.6 5 6 abnormal stomach glandular epithelium morphology 0.848157499157443 0.964696744011952 0.450420478698826 0.333333333333333 5.6 5 6 lactation failure 0.836606571215523 0.951776284426533 0.450420478698826 0.333333333333333 5.6 5 6 increased acute inflammation 0.858979415131074 0.97678230634905 0.450420478698826 0.333333333333333 5.6 5 6 decreased osteoblast cell number 0.917081429372859 1 0.437172817560626 0.323529411764706 5.6 5 6 decreased susceptibility to bacterial infection induced morbidity/mortality 0.911435619945111 1 0.435890785837574 0.32258064516129 5.6 5 6 mixed cellular infiltration to dermis 0.879506952601958 0.992695888211688 0.42226919878015 0.3125 5.6 5 6 decreased circulating growth hormone level 0.879506952601958 0.992695888211688 0.42226919878015 0.3125 5.6 5 6 abnormal fertilization 0.879506952601958 0.992695888211688 0.42226919878015 0.3125 5.6 5 6 abnormal regulatory T cell physiology 0.919214367922146 1 0.411253480551102 0.304347826086957 5.6 5 6 increased susceptibility to fungal infection 0.919214367922146 1 0.411253480551102 0.304347826086957 5.6 5 6 increased urine calcium level 0.968606152164154 1 0.33781535902412 0.25 5.6 5 6 decreased airway responsiveness 0.984916296818668 1 0.307104871840109 0.227272727272727 5.6 5 6 abnormal hypothalamus secretion 0.000212927247444202 0.00219121072776828 1.15636918382914 1 5.5 5 5 abnormal radial glial cell morphology 0.000212927247444202 0.00219121072776828 1.15636918382914 1 5.5 5 5 darkened coat color 9.78853466585369e-07 1.88023011438695e-05 1.15636918382914 1 5.5 5 5 abnormal involuntary movement 2.11199392246326e-06 3.76601066819166e-05 1.15636918382914 1 5.5 5 5 increased hemangioma incidence 2.12094131946054e-05 0.000294739750399893 1.15636918382914 1 5.5 5 5 abnormal corticospinal tract morphology 9.87063738705013e-05 0.00114200979071103 1.15636918382914 1 5.5 5 5 abnormal AMPA-mediated synaptic currents 9.87063738705013e-05 0.00114200979071103 1.15636918382914 1 5.5 5 5 decreased red blood cell distribution width 9.87063738705013e-05 0.00114200979071103 1.15636918382914 1 5.5 5 5 embryonic lethality between implantation and placentation, incomplete penetrance 9.87063738705013e-05 0.00114200979071103 1.15636918382914 1 5.5 5 5 abnormal ion homeostasis 0.000990738114065332 0.00781128703244854 1.15636918382914 1 5.5 5 5 abnormal NMDA-mediated synaptic currents 0.000990738114065332 0.00781128703244854 1.15636918382914 1 5.5 5 5 pancreas cysts 0.000990738114065332 0.00781128703244854 1.15636918382914 1 5.5 5 5 increased neuronal precursor cell number 0.000990738114065332 0.00781128703244854 1.15636918382914 1 5.5 5 5 abnormal CNS synapse formation 0.000990738114065332 0.00781128703244854 1.15636918382914 1 5.5 5 5 positive geotaxis 0.000990738114065332 0.00781128703244854 1.15636918382914 1 5.5 5 5 abnormal optic chiasm morphology 0.000990738114065332 0.00781128703244854 1.15636918382914 1 5.5 5 5 abnormal ductus venosus valve topology 0.000990738114065332 0.00781128703244854 1.15636918382914 1 5.5 5 5 decreased aerobic running capacity 0.00213698002268124 0.0148484296268703 1.15636918382914 1 5.5 5 5 altered response to CNS ischemic injury 0.00213698002268124 0.0148484296268703 1.15636918382914 1 5.5 5 5 urinary incontinence 0.00213698002268124 0.0148484296268703 1.15636918382914 1 5.5 5 5 abnormal eyelid aperture 0.00213698002268124 0.0148484296268703 1.15636918382914 1 5.5 5 5 abnormal lateral ganglionic eminence morphology 0.00213698002268124 0.0148484296268703 1.15636918382914 1 5.5 5 5 abnormal kidney epithelium morphology 0.00213698002268124 0.0148484296268703 1.15636918382914 1 5.5 5 5 accumulation of giant lysosomes in kidney/renal tubule cells 0.00213698002268124 0.0148484296268703 1.15636918382914 1 5.5 5 5 abnormal visual evoked potential 0.00213698002268124 0.0148484296268703 1.15636918382914 1 5.5 5 5 abnormal anterior commissure pars posterior morphology 0.00213698002268124 0.0148484296268703 1.15636918382914 1 5.5 5 5 abnormal umbilical vein topology 0.00213698002268124 0.0148484296268703 1.15636918382914 1 5.5 5 5 increased brain apoptosis 0.00213698002268124 0.0148484296268703 1.15636918382914 1 5.5 5 5 retina hyperplasia 0.00460921789693352 0.0278964221864285 1.15636918382914 1 5.5 5 5 limp posture 0.00460921789693352 0.0278964221864285 1.15636918382914 1 5.5 5 5 abnormal adrenal gland physiology 0.00460921789693352 0.0278964221864285 1.15636918382914 1 5.5 5 5 decreased mortality induced by ionizing radiation 0.00460921789693352 0.0278964221864285 1.15636918382914 1 5.5 5 5 aorta coarctation 0.00460921789693352 0.0278964221864285 1.15636918382914 1 5.5 5 5 abnormal Purkinje cell innervation 0.00460921789693352 0.0278964221864285 1.15636918382914 1 5.5 5 5 increased oligodendrocyte number 0.00460921789693352 0.0278964221864285 1.15636918382914 1 5.5 5 5 decreased brain cholesterol level 0.00460921789693352 0.0278964221864285 1.15636918382914 1 5.5 5 5 decreased skeletal muscle glycogen level 0.00460921789693352 0.0278964221864285 1.15636918382914 1 5.5 5 5 abnormal outer hair cell kinocilium morphology 0.00460921789693352 0.0278964221864285 1.15636918382914 1 5.5 5 5 ductus venosus stenosis 0.00460921789693352 0.0278964221864285 1.15636918382914 1 5.5 5 5 echinocytosis 0.00994120899327172 0.0511453099705551 1.15636918382914 1 5.5 5 5 abnormal lacrimal gland physiology 0.00994120899327172 0.0511453099705551 1.15636918382914 1 5.5 5 5 abnormal avoidance learning behavior 0.00994120899327172 0.0511453099705551 1.15636918382914 1 5.5 5 5 absent ectoplacental cone 0.00994120899327172 0.0511453099705551 1.15636918382914 1 5.5 5 5 delayed brain development 0.00994120899327172 0.0511453099705551 1.15636918382914 1 5.5 5 5 non-obstructive hydrocephaly 0.00994120899327172 0.0511453099705551 1.15636918382914 1 5.5 5 5 reduced NMDA-mediated synaptic currents 0.00994120899327172 0.0511453099705551 1.15636918382914 1 5.5 5 5 chromatolysis 0.00994120899327172 0.0511453099705551 1.15636918382914 1 5.5 5 5 increased post-tetanic potentiation 0.00994120899327172 0.0511453099705551 1.15636918382914 1 5.5 5 5 abnormal hippocampal fimbria morphology 0.00994120899327172 0.0511453099705551 1.15636918382914 1 5.5 5 5 phenotypic reversion 0.00994120899327172 0.0511453099705551 1.15636918382914 1 5.5 5 5 esophageal atresia 0.00994120899327172 0.0511453099705551 1.15636918382914 1 5.5 5 5 abnormal intestinal peristalsis 0.00994120899327172 0.0511453099705551 1.15636918382914 1 5.5 5 5 increased glycerol level 0.00994120899327172 0.0511453099705551 1.15636918382914 1 5.5 5 5 enlarged pancreas 0.00994120899327172 0.0511453099705551 1.15636918382914 1 5.5 5 5 ureter obstruction 0.00994120899327172 0.0511453099705551 1.15636918382914 1 5.5 5 5 abnormal heart left atrium morphology 0.00994120899327172 0.0511453099705551 1.15636918382914 1 5.5 5 5 vestibular saccular degeneration 0.00994120899327172 0.0511453099705551 1.15636918382914 1 5.5 5 5 short scapula 0.00994120899327172 0.0511453099705551 1.15636918382914 1 5.5 5 5 absent parietal bone 0.00994120899327172 0.0511453099705551 1.15636918382914 1 5.5 5 5 abnormal dermis papillary layer morphology 0.00994120899327172 0.0511453099705551 1.15636918382914 1 5.5 5 5 decreased platelet ADP level 0.00994120899327172 0.0511453099705551 1.15636918382914 1 5.5 5 5 abnormal aorta tunica adventitia morphology 0.00994120899327172 0.0511453099705551 1.15636918382914 1 5.5 5 5 abnormal olfactory bulb layer morphology 0.00994120899327172 0.0511453099705551 1.15636918382914 1 5.5 5 5 ectopic hippocampus pyramidal cells 0.00994120899327172 0.0511453099705551 1.15636918382914 1 5.5 5 5 visceral vascular congestion 0.00994120899327172 0.0511453099705551 1.15636918382914 1 5.5 5 5 increased erythrocyte clearance 0.00994120899327172 0.0511453099705551 1.15636918382914 1 5.5 5 5 myocardium hypoplasia 0.00994120899327172 0.0511453099705551 1.15636918382914 1 5.5 5 5 cerebral arteriovenous malformation 0.00994120899327172 0.0511453099705551 1.15636918382914 1 5.5 5 5 abnormal vertebral artery origin 0.00994120899327172 0.0511453099705551 1.15636918382914 1 5.5 5 5 abnormal platelet alpha-granule morphology 0.00994120899327172 0.0511453099705551 1.15636918382914 1 5.5 5 5 heterochrony 9.8310102209616e-06 0.000152015711147391 1.15636918382914 1 5.5 5 5 increased synaptic depression 4.5755608552851e-05 0.000583677314231881 1.15636918382914 1 5.5 5 5 axonal dystrophy 4.5755608552851e-05 0.000583677314231881 1.15636918382914 1 5.5 5 5 intestinal hypoperistalsis 0.000459306364955011 0.00403718933860632 1.15636918382914 1 5.5 5 5 abnormal respiratory conducting tube morphology 0.000459306364955011 0.00403718933860632 1.15636918382914 1 5.5 5 5 abnormal spinal cord dorsal column morphology 0.000459306364955011 0.00403718933860632 1.15636918382914 1 5.5 5 5 abnormal inferior vena cava valve morphology 0.000459306364955011 0.00403718933860632 1.15636918382914 1 5.5 5 5 absent neurocranium 0.0214405714912433 0.0907042787088852 1.15636918382914 1 5.5 5 5 abnormal tooth eruption 0.0214405714912433 0.0907042787088852 1.15636918382914 1 5.5 5 5 ulcerated paws 0.0214405714912433 0.0907042787088852 1.15636918382914 1 5.5 5 5 abnormal pineal gland morphology 0.0214405714912433 0.0907042787088852 1.15636918382914 1 5.5 5 5 optic nerve atrophy 0.0214405714912433 0.0907042787088852 1.15636918382914 1 5.5 5 5 decreased sensitivity to skin irradiation 0.0214405714912433 0.0907042787088852 1.15636918382914 1 5.5 5 5 skin hyperplasia 0.0214405714912433 0.0907042787088852 1.15636918382914 1 5.5 5 5 kinked vibrissae 0.0214405714912433 0.0907042787088852 1.15636918382914 1 5.5 5 5 increased hepatic hemangioma incidence 0.0214405714912433 0.0907042787088852 1.15636918382914 1 5.5 5 5 abnormal nasal mucosa morphology 0.0214405714912433 0.0907042787088852 1.15636918382914 1 5.5 5 5 abnormal oropharynx morphology 0.0214405714912433 0.0907042787088852 1.15636918382914 1 5.5 5 5 improved righting response 0.0214405714912433 0.0907042787088852 1.15636918382914 1 5.5 5 5 decreased lysosomal enzyme secretion 0.0214405714912433 0.0907042787088852 1.15636918382914 1 5.5 5 5 increased lysosomal enzyme secretion 0.0214405714912433 0.0907042787088852 1.15636918382914 1 5.5 5 5 enhanced NMDA-mediated synaptic currents 0.0214405714912433 0.0907042787088852 1.15636918382914 1 5.5 5 5 epidermal cyst 0.0214405714912433 0.0907042787088852 1.15636918382914 1 5.5 5 5 abnormal response to vitamins 0.0214405714912433 0.0907042787088852 1.15636918382914 1 5.5 5 5 ectopic cartilage 0.0214405714912433 0.0907042787088852 1.15636918382914 1 5.5 5 5 absent frontal bone 0.0214405714912433 0.0907042787088852 1.15636918382914 1 5.5 5 5 erythroblastosis 0.0214405714912433 0.0907042787088852 1.15636918382914 1 5.5 5 5 abnormal hemoglobin content 0.0214405714912433 0.0907042787088852 1.15636918382914 1 5.5 5 5 increased placenta apoptosis 0.0214405714912433 0.0907042787088852 1.15636918382914 1 5.5 5 5 absent optic chiasm 0.0214405714912433 0.0907042787088852 1.15636918382914 1 5.5 5 5 abnormal olfactory bulb granule cell layer morphology 0.0214405714912433 0.0907042787088852 1.15636918382914 1 5.5 5 5 abnormal cerebellum lobule morphology 0.0214405714912433 0.0907042787088852 1.15636918382914 1 5.5 5 5 decreased DN3 thymocyte number 0.0214405714912433 0.0907042787088852 1.15636918382914 1 5.5 5 5 increased response to stress-induced hyperthermia 0.0214405714912433 0.0907042787088852 1.15636918382914 1 5.5 5 5 increased T follicular helper cell number 0.0214405714912433 0.0907042787088852 1.15636918382914 1 5.5 5 5 increased thyroid carcinoma incidence 0.0214405714912433 0.0907042787088852 1.15636918382914 1 5.5 5 5 inlet ventricular septal defect 0.0214405714912433 0.0907042787088852 1.15636918382914 1 5.5 5 5 aorta hypoplasia 0.0214405714912433 0.0907042787088852 1.15636918382914 1 5.5 5 5 decreased heart left ventricle size 0.0214405714912433 0.0907042787088852 1.15636918382914 1 5.5 5 5 abnormal paranode morphology 0.0214405714912433 0.0907042787088852 1.15636918382914 1 5.5 5 5 increased Schwann cell number 0.0214405714912433 0.0907042787088852 1.15636918382914 1 5.5 5 5 pale lung 0.0214405714912433 0.0907042787088852 1.15636918382914 1 5.5 5 5 abnormal lung alveolus development 0.0214405714912433 0.0907042787088852 1.15636918382914 1 5.5 5 5 blind ureter 0.0214405714912433 0.0907042787088852 1.15636918382914 1 5.5 5 5 decreased pre-pro B cell number 0.0214405714912433 0.0907042787088852 1.15636918382914 1 5.5 5 5 decreased Paneth cell number 0.0214405714912433 0.0907042787088852 1.15636918382914 1 5.5 5 5 decreased neuronal precursor proliferation 0.0214405714912433 0.0907042787088852 1.15636918382914 1 5.5 5 5 decreased platelet alpha-granule number 0.0214405714912433 0.0907042787088852 1.15636918382914 1 5.5 5 5 impaired synaptic plasticity 1.78432181182749e-10 6.72500076806196e-09 1.12235832548122 0.970588235294118 5.5 5 5 enhanced paired-pulse facilitation 3.42925237291207e-09 1.08665799714889e-07 1.11782354436817 0.966666666666667 5.5 5 5 absent long term depression 7.16178006489836e-09 2.12082475136127e-07 1.11649438438675 0.96551724137931 5.5 5 5 abnormal nest building behavior 1.34562385060839e-07 3.2184993542196e-06 1.11011441647597 0.96 5.5 5 5 intracerebral hemorrhage 1.19533904136272e-06 2.26114514478309e-05 1.10380694820054 0.954545454545455 5.5 5 5 absent ductus venosus valve 5.07851283132955e-06 8.2838037166769e-05 1.09855072463768 0.95 5.5 5 5 abnormal excitatory postsynaptic currents 2.2910767698145e-20 3.08056944049382e-18 1.09706820004303 0.948717948717949 5.5 5 5 abnormal thymus cortex morphology 2.13753816723874e-05 0.000295395899500354 1.09212645139419 0.944444444444444 5.5 5 5 primary atelectasis 2.13753816723874e-05 0.000295395899500354 1.09212645139419 0.944444444444444 5.5 5 5 abnormal touch/ nociception 4.36724220490018e-05 0.000561421963033033 1.08834746713331 0.941176470588235 5.5 5 5 absence seizures 4.36724220490018e-05 0.000561421963033033 1.08834746713331 0.941176470588235 5.5 5 5 impaired behavioral response to addictive substance 8.8945288704432e-05 0.00105107556129347 1.08409610983982 0.9375 5.5 5 5 abnormal synaptic transmission 5.94171677527071e-08 1.49433272572969e-06 1.0792779049072 0.933333333333333 5.5 5 5 abnormal glial cell morphology 0.000180507054825619 0.00191885170460994 1.0792779049072 0.933333333333333 5.5 5 5 liver vascular congestion 0.000180507054825619 0.00191885170460994 1.0792779049072 0.933333333333333 5.5 5 5 lysosomal protein accumulation 0.000364856148210043 0.00340555222766409 1.0737713849842 0.928571428571429 5.5 5 5 increased pulmonary respiratory rate 0.000364856148210043 0.00340555222766409 1.0737713849842 0.928571428571429 5.5 5 5 testis degeneration 0.000364856148210043 0.00340555222766409 1.0737713849842 0.928571428571429 5.5 5 5 multiple persisting craniopharyngeal ducts 0.000364856148210043 0.00340555222766409 1.0737713849842 0.928571428571429 5.5 5 5 abnormal vitelline vein topology 0.000364856148210043 0.00340555222766409 1.0737713849842 0.928571428571429 5.5 5 5 increased thymocyte apoptosis 9.72145768789377e-07 1.87458341074696e-05 1.06741770814997 0.923076923076923 5.5 5 5 dystrophic cardiac calcinosis 0.000734115557682307 0.00611762964735256 1.06741770814997 0.923076923076923 5.5 5 5 increased cochlear inner hair cell number 0.000734115557682307 0.00611762964735256 1.06741770814997 0.923076923076923 5.5 5 5 absent hypoglossal nerve 0.000734115557682307 0.00611762964735256 1.06741770814997 0.923076923076923 5.5 5 5 abnormal startle reflex 3.86736750106831e-06 6.45642728785733e-05 1.06000508517671 0.916666666666667 5.5 5 5 abnormal mating frequency 0.00146935685675492 0.0110423721485736 1.06000508517671 0.916666666666667 5.5 5 5 decreased synaptic depression 0.00146935685675492 0.0110423721485736 1.06000508517671 0.916666666666667 5.5 5 5 dilated bile duct 0.00146935685675492 0.0110423721485736 1.06000508517671 0.916666666666667 5.5 5 5 abnormal pulmonary valve cusp morphology 0.00146935685675492 0.0110423721485736 1.06000508517671 0.916666666666667 5.5 5 5 reduced long term depression 1.13707396190063e-08 3.25111664394001e-07 1.06000508517671 0.916666666666667 5.5 5 5 enlarged liver sinusoidal spaces 4.46166976764843e-08 1.16825300495005e-06 1.05433660878539 0.911764705882353 5.5 5 5 delayed hepatic development 0.0029230975400631 0.0191574651073323 1.05124471257194 0.909090909090909 5.5 5 5 abnormal enteric ganglia morphology 0.0029230975400631 0.0191574651073323 1.05124471257194 0.909090909090909 5.5 5 5 social withdrawal 0.0029230975400631 0.0191574651073323 1.05124471257194 0.909090909090909 5.5 5 5 abnormal dorsal-ventral polarity of the somites 0.0029230975400631 0.0191574651073323 1.05124471257194 0.909090909090909 5.5 5 5 abnormal brain ependyma motile cilium morphology 0.0029230975400631 0.0191574651073323 1.05124471257194 0.909090909090909 5.5 5 5 thin hypoglossal nerve 0.0029230975400631 0.0191574651073323 1.05124471257194 0.909090909090909 5.5 5 5 absent segment of posterior cerebral artery 2.98929145326991e-05 0.000401938512973454 1.04623878536922 0.904761904761905 5.5 5 5 abnormal brain wave pattern 2.53256095630941e-11 1.14540825069448e-09 1.04517983923018 0.903846153846154 5.5 5 5 abnormal object recognition memory 3.39857806816032e-07 7.41575696890246e-06 1.04446248861987 0.903225806451613 5.5 5 5 abnormal response to new environment 6.6465467303207e-07 1.36076419684549e-05 1.04073226544622 0.9 5.5 5 5 abnormal optic cup morphology 6.6465467303207e-07 1.36076419684549e-05 1.04073226544622 0.9 5.5 5 5 decreased paired-pulse facilitation 5.86172346897509e-05 0.000723624671418141 1.04073226544622 0.9 5.5 5 5 decreased myocardial infarction size 5.86172346897509e-05 0.000723624671418141 1.04073226544622 0.9 5.5 5 5 abnormal postnatal subventricular zone morphology 5.86172346897509e-05 0.000723624671418141 1.04073226544622 0.9 5.5 5 5 abnormal response to tactile stimuli 5.86172346897509e-05 0.000723624671418141 1.04073226544622 0.9 5.5 5 5 abnormal optic nerve innervation 0.00577362385605822 0.0325080562693618 1.04073226544622 0.9 5.5 5 5 alcohol preference 0.00577362385605822 0.0325080562693618 1.04073226544622 0.9 5.5 5 5 impaired social transmission of food preference 0.00577362385605822 0.0325080562693618 1.04073226544622 0.9 5.5 5 5 impaired basement membrane formation 0.00577362385605822 0.0325080562693618 1.04073226544622 0.9 5.5 5 5 acrania 0.00577362385605822 0.0325080562693618 1.04073226544622 0.9 5.5 5 5 aneurysm 0.00577362385605822 0.0325080562693618 1.04073226544622 0.9 5.5 5 5 bifid ureter 0.00577362385605822 0.0325080562693618 1.04073226544622 0.9 5.5 5 5 decreased cochlear inner hair cell number 0.00577362385605822 0.0325080562693618 1.04073226544622 0.9 5.5 5 5 abnormal cochlear inner hair cell physiology 0.00577362385605822 0.0325080562693618 1.04073226544622 0.9 5.5 5 5 osteosclerosis 0.00577362385605822 0.0325080562693618 1.04073226544622 0.9 5.5 5 5 impaired behavioral response to morphine 0.00577362385605822 0.0325080562693618 1.04073226544622 0.9 5.5 5 5 protruding tongue 0.00577362385605822 0.0325080562693618 1.04073226544622 0.9 5.5 5 5 abnormal cerebellar granule cell migration 0.00577362385605822 0.0325080562693618 1.04073226544622 0.9 5.5 5 5 increased circulating fructosamine level 0.00577362385605822 0.0325080562693618 1.04073226544622 0.9 5.5 5 5 lethality during fetal growth through weaning, complete penetrance 0.00577362385605822 0.0325080562693618 1.04073226544622 0.9 5.5 5 5 abnormal cell morphology 2.74613214558654e-22 4.14000224978576e-20 1.03464611184712 0.894736842105263 5.5 5 5 seizures 2.74613214558654e-22 4.14000224978576e-20 1.03464611184712 0.894736842105263 5.5 5 5 persistence of hyaloid vascular system 2.9936090505365e-08 8.13836340241481e-07 1.03464611184712 0.894736842105263 5.5 5 5 decreased neuron apoptosis 2.9936090505365e-08 8.13836340241481e-07 1.03464611184712 0.894736842105263 5.5 5 5 abnormal nasal septum morphology 0.000114390853241721 0.00128754410605784 1.03464611184712 0.894736842105263 5.5 5 5 embryonic lethality between implantation and somite formation, incomplete penetrance 0.000114390853241721 0.00128754410605784 1.03464611184712 0.894736842105263 5.5 5 5 abnormal contextual conditioning behavior 3.3010098816333e-11 1.45332072222351e-09 1.0302198183205 0.890909090909091 5.5 5 5 increased brain weight 4.86742656707222e-06 7.96560762210009e-05 1.02788371895923 0.888888888888889 5.5 5 5 abnormal mitral valve morphology 0.000222048745061917 0.00225447450343477 1.02788371895923 0.888888888888889 5.5 5 5 abnormal hypoglossal nerve topology 0.000222048745061917 0.00225447450343477 1.02788371895923 0.888888888888889 5.5 5 5 abnormal cholinergic neuron morphology 0.0113069152916085 0.0549334995856956 1.02788371895923 0.888888888888889 5.5 5 5 abnormal geniculate ganglion morphology 0.0113069152916085 0.0549334995856956 1.02788371895923 0.888888888888889 5.5 5 5 abnormal kindling response 0.0113069152916085 0.0549334995856956 1.02788371895923 0.888888888888889 5.5 5 5 decreased level of surface class I molecules 0.0113069152916085 0.0549334995856956 1.02788371895923 0.888888888888889 5.5 5 5 increased pheochromocytoma incidence 0.0113069152916085 0.0549334995856956 1.02788371895923 0.888888888888889 5.5 5 5 abnormal posterior semicircular canal morphology 0.0113069152916085 0.0549334995856956 1.02788371895923 0.888888888888889 5.5 5 5 biliary cyst 0.0113069152916085 0.0549334995856956 1.02788371895923 0.888888888888889 5.5 5 5 decreased fear-related response 0.0113069152916085 0.0549334995856956 1.02788371895923 0.888888888888889 5.5 5 5 decreased cellular sensitivity to ionizing radiation 0.0113069152916085 0.0549334995856956 1.02788371895923 0.888888888888889 5.5 5 5 decreased vestibular hair cell number 0.0113069152916085 0.0549334995856956 1.02788371895923 0.888888888888889 5.5 5 5 enhanced conditioned place preference behavior 0.0113069152916085 0.0549334995856956 1.02788371895923 0.888888888888889 5.5 5 5 abnormal cerebellar layer morphology 0.0113069152916085 0.0549334995856956 1.02788371895923 0.888888888888889 5.5 5 5 axonal spheroids 0.0113069152916085 0.0549334995856956 1.02788371895923 0.888888888888889 5.5 5 5 retropulsion 0.0113069152916085 0.0549334995856956 1.02788371895923 0.888888888888889 5.5 5 5 abnormal ventricle myocardium morphology 0.0113069152916085 0.0549334995856956 1.02788371895923 0.888888888888889 5.5 5 5 decreased effector memory CD4-positive, alpha-beta T cell number 0.0113069152916085 0.0549334995856956 1.02788371895923 0.888888888888889 5.5 5 5 reduced AMPA-mediated synaptic currents 0.0113069152916085 0.0549334995856956 1.02788371895923 0.888888888888889 5.5 5 5 abnormal infrahyoid muscle connection 0.0113069152916085 0.0549334995856956 1.02788371895923 0.888888888888889 5.5 5 5 abnormal coronary sinus connection 0.0113069152916085 0.0549334995856956 1.02788371895923 0.888888888888889 5.5 5 5 symmetric azygos veins 0.0113069152916085 0.0549334995856956 1.02788371895923 0.888888888888889 5.5 5 5 increased cardiac muscle glycogen level 0.0113069152916085 0.0549334995856956 1.02788371895923 0.888888888888889 5.5 5 5 decreased platelet dense granule number 0.0113069152916085 0.0549334995856956 1.02788371895923 0.888888888888889 5.5 5 5 embryonic lethality between somite formation and embryo turning, complete penetrance 1.40150691926979e-13 8.71562115420898e-12 1.02421270567724 0.885714285714286 5.5 5 5 ventricular hypoplasia 9.3776603464322e-06 0.000147173060641956 1.02294197031039 0.884615384615385 5.5 5 5 abnormal cued conditioning behavior 4.50228710238948e-10 1.64697634811674e-08 1.02032575043747 0.882352941176471 5.5 5 5 abnormal bone marrow cavity morphology 0.000428491788620159 0.00383771641198662 1.02032575043747 0.882352941176471 5.5 5 5 abnormal dorsal-ventral axis patterning 0.000428491788620159 0.00383771641198662 1.02032575043747 0.882352941176471 5.5 5 5 abnormal glutamate-mediated receptor currents 0.000428491788620159 0.00383771641198662 1.02032575043747 0.882352941176471 5.5 5 5 abnormal embryonic-extraembryonic boundary morphology 0.000428491788620159 0.00383771641198662 1.02032575043747 0.882352941176471 5.5 5 5 enhanced behavioral response to cocaine 0.000428491788620159 0.00383771641198662 1.02032575043747 0.882352941176471 5.5 5 5 abnormal ductus venosus valve morphology 0.000428491788620159 0.00383771641198662 1.02032575043747 0.882352941176471 5.5 5 5 abnormal locomotor coordination 7.90887319026596e-07 1.58826506066727e-05 1.01620322215288 0.878787878787879 5.5 5 5 abnormal depression-related behavior 1.5062415608479e-06 2.7740842068438e-05 1.0118230358505 0.875 5.5 5 5 increased cochlear outer hair cell number 0.000821439417673925 0.00665579984190192 1.0118230358505 0.875 5.5 5 5 dystonia 0.000821439417673925 0.00665579984190192 1.0118230358505 0.875 5.5 5 5 impaired somite development 0.000821439417673925 0.00665579984190192 1.0118230358505 0.875 5.5 5 5 poor grooming 0.0219148830166995 0.0907042787088852 1.0118230358505 0.875 5.5 5 5 coarse hair 0.0219148830166995 0.0907042787088852 1.0118230358505 0.875 5.5 5 5 abnormal cellular cholesterol metabolism 0.0219148830166995 0.0907042787088852 1.0118230358505 0.875 5.5 5 5 colon polyps 0.0219148830166995 0.0907042787088852 1.0118230358505 0.875 5.5 5 5 liver cysts 0.0219148830166995 0.0907042787088852 1.0118230358505 0.875 5.5 5 5 pulmonary interstitial fibrosis 0.0219148830166995 0.0907042787088852 1.0118230358505 0.875 5.5 5 5 elevated level of mitotic sister chromatid exchange 0.0219148830166995 0.0907042787088852 1.0118230358505 0.875 5.5 5 5 binucleate 0.0219148830166995 0.0907042787088852 1.0118230358505 0.875 5.5 5 5 tau protein deposits 0.0219148830166995 0.0907042787088852 1.0118230358505 0.875 5.5 5 5 abnormal extraembryonic tissue physiology 0.0219148830166995 0.0907042787088852 1.0118230358505 0.875 5.5 5 5 absent interparietal bone 0.0219148830166995 0.0907042787088852 1.0118230358505 0.875 5.5 5 5 abnormal NK cell morphology 0.0219148830166995 0.0907042787088852 1.0118230358505 0.875 5.5 5 5 abnormal somite size 0.0219148830166995 0.0907042787088852 1.0118230358505 0.875 5.5 5 5 abnormal olfactory tract morphology 0.0219148830166995 0.0907042787088852 1.0118230358505 0.875 5.5 5 5 craniofacial phenotype 0.0219148830166995 0.0907042787088852 1.0118230358505 0.875 5.5 5 5 stomach epithelial hyperplasia 0.0219148830166995 0.0907042787088852 1.0118230358505 0.875 5.5 5 5 impaired behavioral response to alcohol 0.0219148830166995 0.0907042787088852 1.0118230358505 0.875 5.5 5 5 abnormal olfactory bulb glomerular layer morphology 0.0219148830166995 0.0907042787088852 1.0118230358505 0.875 5.5 5 5 abnormal olfactory bulb mitral cell layer morphology 0.0219148830166995 0.0907042787088852 1.0118230358505 0.875 5.5 5 5 decreased hippocampus pyramidal cell number 0.0219148830166995 0.0907042787088852 1.0118230358505 0.875 5.5 5 5 abnormal cerebellum deep nucleus morphology 0.0219148830166995 0.0907042787088852 1.0118230358505 0.875 5.5 5 5 increased caudal vertebrae number 0.0219148830166995 0.0907042787088852 1.0118230358505 0.875 5.5 5 5 abnormal brain ependyma morphology 0.0219148830166995 0.0907042787088852 1.0118230358505 0.875 5.5 5 5 abnormal circulating serum amyloid protein level 0.0219148830166995 0.0907042787088852 1.0118230358505 0.875 5.5 5 5 pleural effusion 0.0219148830166995 0.0907042787088852 1.0118230358505 0.875 5.5 5 5 ostium secundum atrial septal defect 0.0219148830166995 0.0907042787088852 1.0118230358505 0.875 5.5 5 5 abnormal hepatic vein morphology 0.0219148830166995 0.0907042787088852 1.0118230358505 0.875 5.5 5 5 lung situs inversus 0.0219148830166995 0.0907042787088852 1.0118230358505 0.875 5.5 5 5 abnormal branching involved in ureteric bud morphogenesis 0.0219148830166995 0.0907042787088852 1.0118230358505 0.875 5.5 5 5 impaired neuron differentiation 0.0219148830166995 0.0907042787088852 1.0118230358505 0.875 5.5 5 5 increased testis apoptosis 0.0219148830166995 0.0907042787088852 1.0118230358505 0.875 5.5 5 5 absent hypoglossal canal 0.0219148830166995 0.0907042787088852 1.0118230358505 0.875 5.5 5 5 retropleural edema 0.0219148830166995 0.0907042787088852 1.0118230358505 0.875 5.5 5 5 embryo cyst 0.0219148830166995 0.0907042787088852 1.0118230358505 0.875 5.5 5 5 abnormal eyelid morphology 2.85703351999031e-06 4.901290262742e-05 1.00716025688344 0.870967741935484 5.5 5 5 preaxial polydactyly 2.85703351999031e-06 4.901290262742e-05 1.00716025688344 0.870967741935484 5.5 5 5 abnormal inhibitory postsynaptic currents 4.04923534486176e-12 2.12052061480918e-10 1.00332032126352 0.867647058823529 5.5 5 5 absent incisors 0.0015631252552088 0.0115037694447689 1.00218662598525 0.866666666666667 5.5 5 5 abnormal pup retrieval 0.0015631252552088 0.0115037694447689 1.00218662598525 0.866666666666667 5.5 5 5 abnormal seizure response to electrical stimulation 0.0015631252552088 0.0115037694447689 1.00218662598525 0.866666666666667 5.5 5 5 decreased aggression towards males 0.0015631252552088 0.0115037694447689 1.00218662598525 0.866666666666667 5.5 5 5 abnormal olfactory nerve morphology 0.0015631252552088 0.0115037694447689 1.00218662598525 0.866666666666667 5.5 5 5 abnormal neurotransmitter secretion 0.0015631252552088 0.0115037694447689 1.00218662598525 0.866666666666667 5.5 5 5 abnormal cerebral aqueduct morphology 0.0015631252552088 0.0115037694447689 1.00218662598525 0.866666666666667 5.5 5 5 herniated liver 0.0015631252552088 0.0115037694447689 1.00218662598525 0.866666666666667 5.5 5 5 liver hypoplasia 1.8332082227917e-09 6.08014060559247e-08 1.0007041013906 0.865384615384615 5.5 5 5 abnormal channel response 0.000123088731086851 0.00136081430479351 0.998682476943347 0.863636363636364 5.5 5 5 abnormal limb posture 0.000123088731086851 0.00136081430479351 0.998682476943347 0.863636363636364 5.5 5 5 abnormal mesenteric lymph node morphology 0.000123088731086851 0.00136081430479351 0.998682476943347 0.863636363636364 5.5 5 5 increased mammary gland tumor incidence 0.000123088731086851 0.00136081430479351 0.998682476943347 0.863636363636364 5.5 5 5 embryonic lethality before implantation, incomplete penetrance 0.000123088731086851 0.00136081430479351 0.998682476943347 0.863636363636364 5.5 5 5 blood in lymph vessels 1.01439360398505e-05 0.000152576337596111 0.996869986059602 0.862068965517241 5.5 5 5 abnormal lysosome morphology 8.5804917391805e-07 1.7031006915388e-05 0.995762352741758 0.861111111111111 5.5 5 5 decreased brain weight 5.63558235875096e-10 2.03166827788305e-08 0.994071754519785 0.859649122807018 5.5 5 5 abnormal lung development 3.51258523828602e-14 2.39385089869492e-12 0.993117063759142 0.858823529411765 5.5 5 5 abnormal CNS synaptic transmission 2.82136659540897e-16 2.69928823310762e-14 0.992842228540169 0.858585858585859 5.5 5 5 abnormal embryo size 2.28010925994323e-18 2.57807808368582e-16 0.992635494083419 0.858407079646018 5.5 5 5 gliosis 9.26219089297207e-11 3.68635197540289e-09 0.991173586139261 0.857142857142857 5.5 5 5 abnormal somite shape 1.89762273892621e-05 0.000266910938049935 0.991173586139261 0.857142857142857 5.5 5 5 absent corpus callosum 1.89762273892621e-05 0.000266910938049935 0.991173586139261 0.857142857142857 5.5 5 5 straub tail 1.89762273892621e-05 0.000266910938049935 0.991173586139261 0.857142857142857 5.5 5 5 subcutaneous edema 1.89762273892621e-05 0.000266910938049935 0.991173586139261 0.857142857142857 5.5 5 5 abnormal interparietal bone morphology 0.00294967201451588 0.0191574651073323 0.991173586139261 0.857142857142857 5.5 5 5 midline facial cleft 0.00294967201451588 0.0191574651073323 0.991173586139261 0.857142857142857 5.5 5 5 abnormal placing response 0.00294967201451588 0.0191574651073323 0.991173586139261 0.857142857142857 5.5 5 5 abnormal adrenal gland secretion 0.00294967201451588 0.0191574651073323 0.991173586139261 0.857142857142857 5.5 5 5 abnormal prepulse inhibition 0.00294967201451588 0.0191574651073323 0.991173586139261 0.857142857142857 5.5 5 5 amyloid beta deposits 0.00294967201451588 0.0191574651073323 0.991173586139261 0.857142857142857 5.5 5 5 absent olfactory bulb 0.00294967201451588 0.0191574651073323 0.991173586139261 0.857142857142857 5.5 5 5 pulmonary alveolar hemorrhage 0.00294967201451588 0.0191574651073323 0.991173586139261 0.857142857142857 5.5 5 5 abnormal renal tubule epithelial cell primary cilium morphology 0.00294967201451588 0.0191574651073323 0.991173586139261 0.857142857142857 5.5 5 5 failure of atrioventricular cushion closure 0.041933155571301 0.153057556102144 0.991173586139261 0.857142857142857 5.5 5 5 polyphalangy 0.041933155571301 0.153057556102144 0.991173586139261 0.857142857142857 5.5 5 5 mottled coat 0.041933155571301 0.153057556102144 0.991173586139261 0.857142857142857 5.5 5 5 small L4 dorsal root ganglion 0.041933155571301 0.153057556102144 0.991173586139261 0.857142857142857 5.5 5 5 abnormal oculomotor nerve morphology 0.041933155571301 0.153057556102144 0.991173586139261 0.857142857142857 5.5 5 5 skin photosensitivity 0.041933155571301 0.153057556102144 0.991173586139261 0.857142857142857 5.5 5 5 abnormal lacrimal gland morphology 0.041933155571301 0.153057556102144 0.991173586139261 0.857142857142857 5.5 5 5 excessive tearing 0.041933155571301 0.153057556102144 0.991173586139261 0.857142857142857 5.5 5 5 abnormal axial mesoderm 0.041933155571301 0.153057556102144 0.991173586139261 0.857142857142857 5.5 5 5 abnormal tumor incidence 0.041933155571301 0.153057556102144 0.991173586139261 0.857142857142857 5.5 5 5 abnormal gastrulation movements 0.041933155571301 0.153057556102144 0.991173586139261 0.857142857142857 5.5 5 5 abnormal brain ventricular system morphology 0.041933155571301 0.153057556102144 0.991173586139261 0.857142857142857 5.5 5 5 abnormal melanocyte morphology 0.041933155571301 0.153057556102144 0.991173586139261 0.857142857142857 5.5 5 5 abnormal superior semicircular canal morphology 0.041933155571301 0.153057556102144 0.991173586139261 0.857142857142857 5.5 5 5 absent tunnel of Corti 0.041933155571301 0.153057556102144 0.991173586139261 0.857142857142857 5.5 5 5 decreased cardiomyocyte apoptosis 0.041933155571301 0.153057556102144 0.991173586139261 0.857142857142857 5.5 5 5 abnormal optic tract morphology 0.041933155571301 0.153057556102144 0.991173586139261 0.857142857142857 5.5 5 5 absent deltoid tuberosity 0.041933155571301 0.153057556102144 0.991173586139261 0.857142857142857 5.5 5 5 abnormal cochlear nerve compound action potential 0.041933155571301 0.153057556102144 0.991173586139261 0.857142857142857 5.5 5 5 abnormal talus morphology 0.041933155571301 0.153057556102144 0.991173586139261 0.857142857142857 5.5 5 5 decreased tidal volume 0.041933155571301 0.153057556102144 0.991173586139261 0.857142857142857 5.5 5 5 enhanced behavioral response to alcohol 0.041933155571301 0.153057556102144 0.991173586139261 0.857142857142857 5.5 5 5 abnormal cerebellum white matter morphology 0.041933155571301 0.153057556102144 0.991173586139261 0.857142857142857 5.5 5 5 decreased DN2 thymocyte number 0.041933155571301 0.153057556102144 0.991173586139261 0.857142857142857 5.5 5 5 arteritis 0.041933155571301 0.153057556102144 0.991173586139261 0.857142857142857 5.5 5 5 abnormal retina inner limiting membrane morphology 0.041933155571301 0.153057556102144 0.991173586139261 0.857142857142857 5.5 5 5 abnormal conotruncal ridge morphology 0.041933155571301 0.153057556102144 0.991173586139261 0.857142857142857 5.5 5 5 abnormal aortic valve cusp morphology 0.041933155571301 0.153057556102144 0.991173586139261 0.857142857142857 5.5 5 5 altered tumor pathology 0.041933155571301 0.153057556102144 0.991173586139261 0.857142857142857 5.5 5 5 abnormal brain ependyma motile cilium physiology 0.041933155571301 0.153057556102144 0.991173586139261 0.857142857142857 5.5 5 5 decreased CD8-positive, naive alpha-beta T cell number 0.041933155571301 0.153057556102144 0.991173586139261 0.857142857142857 5.5 5 5 dysmyelination 0.041933155571301 0.153057556102144 0.991173586139261 0.857142857142857 5.5 5 5 abnormal Mullerian duct topology 0.041933155571301 0.153057556102144 0.991173586139261 0.857142857142857 5.5 5 5 embryo tumor 0.041933155571301 0.153057556102144 0.991173586139261 0.857142857142857 5.5 5 5 abnormal hippocampus pyramidal cell morphology 1.60215050082148e-06 2.89843590603158e-05 0.991173586139261 0.857142857142857 5.5 5 5 abnormal anxiety-related response 0.000230963155632062 0.00233071338594221 0.991173586139261 0.857142857142857 5.5 5 5 trunk curl 0.000230963155632062 0.00233071338594221 0.991173586139261 0.857142857142857 5.5 5 5 pericardial effusion 1.71959281230411e-10 6.5305146879488e-09 0.988509141015231 0.854838709677419 5.5 5 5 abnormal head morphology 1.94862058061118e-09 6.42012409837127e-08 0.988170029817627 0.854545454545454 5.5 5 5 abnormal excitatory postsynaptic potential 2.24661361847098e-13 1.31492973551684e-11 0.987144425219996 0.853658536585366 5.5 5 5 abnormal cell differentiation 2.55741928970087e-07 5.67998257422404e-06 0.987144425219996 0.853658536585366 5.5 5 5 abnormal trigeminal nerve morphology 3.53115045777524e-05 0.000463521728955984 0.985055230669266 0.851851851851852 5.5 5 5 abnormal brain commissure morphology 3.53115045777524e-05 0.000463521728955984 0.985055230669266 0.851851851851852 5.5 5 5 abnormal pericardium morphology 0.000430441358369555 0.00383771641198662 0.982913806254767 0.85 5.5 5 5 abnormal cell proliferation 0.000430441358369555 0.00383771641198662 0.982913806254767 0.85 5.5 5 5 abnormal vascular regression 0.000430441358369555 0.00383771641198662 0.982913806254767 0.85 5.5 5 5 anencephaly 0.000430441358369555 0.00383771641198662 0.982913806254767 0.85 5.5 5 5 abnormal optic stalk morphology 0.000430441358369555 0.00383771641198662 0.982913806254767 0.85 5.5 5 5 abnormal sperm mitochondrial sheath morphology 0.000430441358369555 0.00383771641198662 0.982913806254767 0.85 5.5 5 5 abnormal fertility/fecundity 8.57203281185327e-12 4.18096698421275e-10 0.982121772567213 0.849315068493151 5.5 5 5 embryonic lethality before implantation, complete penetrance 4.22887011988038e-19 5.00919734438211e-17 0.980601067887109 0.848 5.5 5 5 failure to gastrulate 7.59016160642804e-08 1.87865940258605e-06 0.980399960202965 0.847826086956522 5.5 5 5 abnormal nasal bone morphology 6.53359959131594e-05 0.000792796535775531 0.978466232470809 0.846153846153846 5.5 5 5 abnormal sympathetic ganglion morphology 0.00551318400165428 0.0318560864207085 0.978466232470809 0.846153846153846 5.5 5 5 abnormal tail bud morphology 0.00551318400165428 0.0318560864207085 0.978466232470809 0.846153846153846 5.5 5 5 abnormal coping response 0.00551318400165428 0.0318560864207085 0.978466232470809 0.846153846153846 5.5 5 5 abnormal soleus morphology 0.00551318400165428 0.0318560864207085 0.978466232470809 0.846153846153846 5.5 5 5 anal atresia 0.00551318400165428 0.0318560864207085 0.978466232470809 0.846153846153846 5.5 5 5 tracheoesophageal fistula 0.00551318400165428 0.0318560864207085 0.978466232470809 0.846153846153846 5.5 5 5 abnormal afterhyperpolarization 0.00551318400165428 0.0318560864207085 0.978466232470809 0.846153846153846 5.5 5 5 abnormal retinal inner plexiform layer morphology 0.00551318400165428 0.0318560864207085 0.978466232470809 0.846153846153846 5.5 5 5 decreased endocochlear potential 0.00551318400165428 0.0318560864207085 0.978466232470809 0.846153846153846 5.5 5 5 empty decidua capsularis 0.00551318400165428 0.0318560864207085 0.978466232470809 0.846153846153846 5.5 5 5 abnormal aorta tunica media morphology 0.00551318400165428 0.0318560864207085 0.978466232470809 0.846153846153846 5.5 5 5 abnormal nervous system electrophysiology 4.26781970200555e-13 2.41277307016791e-11 0.977407286331771 0.845238095238095 5.5 5 5 trabecula carnea hypoplasia 1.39512977565157e-07 3.29920835557035e-06 0.976489533011272 0.844444444444444 5.5 5 5 increased susceptibility to pharmacologically induced seizures 1.16226383942333e-14 8.64460476506368e-13 0.975686498855835 0.84375 5.5 5 5 neonatal lethality 1.01513100993593e-05 0.000152576337596111 0.975686498855835 0.84375 5.5 5 5 abnormal long term potentiation 1.01513100993593e-05 0.000152576337596111 0.975686498855835 0.84375 5.5 5 5 pancreatic islet hyperplasia 1.01513100993593e-05 0.000152576337596111 0.975686498855835 0.84375 5.5 5 5 increased fibroblast apoptosis 1.01513100993593e-05 0.000152576337596111 0.975686498855835 0.84375 5.5 5 5 preweaning lethality, complete penetrance 3.38880664313459e-104 1.68593130495946e-100 0.975100500958625 0.843243243243243 5.5 5 5 abnormal dendritic spine morphology 2.24726122405297e-08 6.24587965902992e-07 0.97497793930692 0.843137254901961 5.5 5 5 kyphoscoliosis 0.000796224168102957 0.00648316732620656 0.973784575856116 0.842105263157895 5.5 5 5 abnormal stationary movement 0.000796224168102957 0.00648316732620656 0.973784575856116 0.842105263157895 5.5 5 5 unresponsive to tactile stimuli 0.000796224168102957 0.00648316732620656 0.973784575856116 0.842105263157895 5.5 5 5 abnormal long term depression 0.000796224168102957 0.00648316732620656 0.973784575856116 0.842105263157895 5.5 5 5 delayed sexual maturation 0.000796224168102957 0.00648316732620656 0.973784575856116 0.842105263157895 5.5 5 5 abnormal cochlear inner hair cell morphology 0.000796224168102957 0.00648316732620656 0.973784575856116 0.842105263157895 5.5 5 5 decreased eye pigmentation 0.000796224168102957 0.00648316732620656 0.973784575856116 0.842105263157895 5.5 5 5 abnormal behavioral response to xenobiotic 0.000796224168102957 0.00648316732620656 0.973784575856116 0.842105263157895 5.5 5 5 muscular atrophy 2.55464121268319e-07 5.67998257422404e-06 0.972401359129048 0.840909090909091 5.5 5 5 increased cellular sensitivity to ionizing radiation 0.000120150468282661 0.00134628058492396 0.971350114416476 0.84 5.5 5 5 abnormal cranial ganglia morphology 1.8597827872757e-05 0.000265112302770676 0.969858025147019 0.838709677419355 5.5 5 5 abnormal nose morphology 1.8597827872757e-05 0.000265112302770676 0.969858025147019 0.838709677419355 5.5 5 5 abnormal neuron morphology 1.16419802866184e-14 8.64460476506368e-13 0.969481234927459 0.838383838383838 5.5 5 5 abnormal posture 4.73282135380222e-12 2.42740064280062e-10 0.968459191456903 0.8375 5.5 5 5 abnormal axon guidance 4.65928448746851e-07 9.78056553804043e-06 0.968123037624395 0.837209302325581 5.5 5 5 ataxia 3.46289196334777e-28 8.61394375882757e-26 0.967457386470913 0.836633663366337 5.5 5 5 astrocytosis 5.23601069885521e-11 2.24561665748316e-09 0.966281098816129 0.835616438356164 5.5 5 5 abnormal axon morphology 1.89220425134139e-15 1.71158475462244e-13 0.963640986524282 0.833333333333333 5.5 5 5 abnormal maxilla morphology 2.19173216561931e-08 6.12576827188542e-07 0.963640986524282 0.833333333333333 5.5 5 5 neurodegeneration 2.19173216561931e-08 6.12576827188542e-07 0.963640986524282 0.833333333333333 5.5 5 5 vertebral transformation 1.35736123090418e-07 3.23103929365947e-06 0.963640986524282 0.833333333333333 5.5 5 5 abnormal nursing 0.000219491791541134 0.00224224160763273 0.963640986524282 0.833333333333333 5.5 5 5 increased stereotypic behavior 0.000219491791541134 0.00224224160763273 0.963640986524282 0.833333333333333 5.5 5 5 blindness 0.000219491791541134 0.00224224160763273 0.963640986524282 0.833333333333333 5.5 5 5 mesocardia 0.010191800956604 0.0513200503634665 0.963640986524282 0.833333333333333 5.5 5 5 abnormal superior cervical ganglion morphology 0.010191800956604 0.0513200503634665 0.963640986524282 0.833333333333333 5.5 5 5 abnormal enteric nervous system morphology 0.010191800956604 0.0513200503634665 0.963640986524282 0.833333333333333 5.5 5 5 impaired embryo implantation 0.010191800956604 0.0513200503634665 0.963640986524282 0.833333333333333 5.5 5 5 abnormal thymus involution 0.010191800956604 0.0513200503634665 0.963640986524282 0.833333333333333 5.5 5 5 myocarditis 0.010191800956604 0.0513200503634665 0.963640986524282 0.833333333333333 5.5 5 5 interstitial pneumonia 0.010191800956604 0.0513200503634665 0.963640986524282 0.833333333333333 5.5 5 5 increased litter size 0.010191800956604 0.0513200503634665 0.963640986524282 0.833333333333333 5.5 5 5 abnormal embryonic growth/weight/body size 0.010191800956604 0.0513200503634665 0.963640986524282 0.833333333333333 5.5 5 5 abnormal vascular endothelial cell development 0.010191800956604 0.0513200503634665 0.963640986524282 0.833333333333333 5.5 5 5 increased osteosarcoma incidence 0.010191800956604 0.0513200503634665 0.963640986524282 0.833333333333333 5.5 5 5 decreased left ventricle systolic pressure 0.010191800956604 0.0513200503634665 0.963640986524282 0.833333333333333 5.5 5 5 stria vascularis degeneration 0.010191800956604 0.0513200503634665 0.963640986524282 0.833333333333333 5.5 5 5 abnormal palatine bone morphology 0.010191800956604 0.0513200503634665 0.963640986524282 0.833333333333333 5.5 5 5 abnormal behavioral response to addictive substance 0.010191800956604 0.0513200503634665 0.963640986524282 0.833333333333333 5.5 5 5 decreased mammary gland epithelial cell proliferation 0.010191800956604 0.0513200503634665 0.963640986524282 0.833333333333333 5.5 5 5 increased skeletal muscle glycogen level 0.010191800956604 0.0513200503634665 0.963640986524282 0.833333333333333 5.5 5 5 persistent right dorsal aorta 0.010191800956604 0.0513200503634665 0.963640986524282 0.833333333333333 5.5 5 5 abnormal vitelline vein connection 0.010191800956604 0.0513200503634665 0.963640986524282 0.833333333333333 5.5 5 5 hemoglobinuria 0.0789373839811013 0.236147615938652 0.963640986524282 0.833333333333333 5.5 5 5 shiny fur 0.0789373839811013 0.236147615938652 0.963640986524282 0.833333333333333 5.5 5 5 abnormal urethra morphology 0.0789373839811013 0.236147615938652 0.963640986524282 0.833333333333333 5.5 5 5 hyperresponsive 0.0789373839811013 0.236147615938652 0.963640986524282 0.833333333333333 5.5 5 5 jumpy 0.0789373839811013 0.236147615938652 0.963640986524282 0.833333333333333 5.5 5 5 increased embryo size 0.0789373839811013 0.236147615938652 0.963640986524282 0.833333333333333 5.5 5 5 abnormal chemically-elicited antinociception 0.0789373839811013 0.236147615938652 0.963640986524282 0.833333333333333 5.5 5 5 abnormal parental behavior 0.0789373839811013 0.236147615938652 0.963640986524282 0.833333333333333 5.5 5 5 abnormal gland physiology 0.0789373839811013 0.236147615938652 0.963640986524282 0.833333333333333 5.5 5 5 loss of hippocampal neurons 0.0789373839811013 0.236147615938652 0.963640986524282 0.833333333333333 5.5 5 5 decreased liver function 0.0789373839811013 0.236147615938652 0.963640986524282 0.833333333333333 5.5 5 5 shortened QT interval 0.0789373839811013 0.236147615938652 0.963640986524282 0.833333333333333 5.5 5 5 absent molars 0.0789373839811013 0.236147615938652 0.963640986524282 0.833333333333333 5.5 5 5 abnormal cholesterol level 0.0789373839811013 0.236147615938652 0.963640986524282 0.833333333333333 5.5 5 5 abnormal motor nerve collateral sprouting 0.0789373839811013 0.236147615938652 0.963640986524282 0.833333333333333 5.5 5 5 abnormal extensor digitorum longus morphology 0.0789373839811013 0.236147615938652 0.963640986524282 0.833333333333333 5.5 5 5 abnormal physical strength 0.0789373839811013 0.236147615938652 0.963640986524282 0.833333333333333 5.5 5 5 decreased prostate gland weight 0.0789373839811013 0.236147615938652 0.963640986524282 0.833333333333333 5.5 5 5 variegated coat color 0.0789373839811013 0.236147615938652 0.963640986524282 0.833333333333333 5.5 5 5 abnormal pulmonary respiratory rate 0.0789373839811013 0.236147615938652 0.963640986524282 0.833333333333333 5.5 5 5 abnormal right lung morphology 0.0789373839811013 0.236147615938652 0.963640986524282 0.833333333333333 5.5 5 5 delayed chorioallantoic fusion 0.0789373839811013 0.236147615938652 0.963640986524282 0.833333333333333 5.5 5 5 abnormal neural crest cell morphology 0.0789373839811013 0.236147615938652 0.963640986524282 0.833333333333333 5.5 5 5 increased transitional stage T1 B cell number 0.0789373839811013 0.236147615938652 0.963640986524282 0.833333333333333 5.5 5 5 enlarged lymphatic vessel 0.0789373839811013 0.236147615938652 0.963640986524282 0.833333333333333 5.5 5 5 kidney microaneurysm 0.0789373839811013 0.236147615938652 0.963640986524282 0.833333333333333 5.5 5 5 thick pulmonary valve cusps 0.0789373839811013 0.236147615938652 0.963640986524282 0.833333333333333 5.5 5 5 abnormal intestinal enteroendocrine cell morphology 0.0789373839811013 0.236147615938652 0.963640986524282 0.833333333333333 5.5 5 5 ectopic ureteric bud 0.0789373839811013 0.236147615938652 0.963640986524282 0.833333333333333 5.5 5 5 decreased macrophage nitric oxide production 0.0789373839811013 0.236147615938652 0.963640986524282 0.833333333333333 5.5 5 5 abnormal ureteric bud tip morphology 0.0789373839811013 0.236147615938652 0.963640986524282 0.833333333333333 5.5 5 5 abnormal endocrine pancreas development 0.0789373839811013 0.236147615938652 0.963640986524282 0.833333333333333 5.5 5 5 increased total retina thickness 0.0789373839811013 0.236147615938652 0.963640986524282 0.833333333333333 5.5 5 5 absent midbrain 0.0789373839811013 0.236147615938652 0.963640986524282 0.833333333333333 5.5 5 5 delayed limb development 0.0789373839811013 0.236147615938652 0.963640986524282 0.833333333333333 5.5 5 5 increased bone trabecular spacing 0.0789373839811013 0.236147615938652 0.963640986524282 0.833333333333333 5.5 5 5 increased CD11b-high dendritic cell number 0.0789373839811013 0.236147615938652 0.963640986524282 0.833333333333333 5.5 5 5 absent thymus corticomedullary boundary 0.0789373839811013 0.236147615938652 0.963640986524282 0.833333333333333 5.5 5 5 ciliary body hypoplasia 0.0789373839811013 0.236147615938652 0.963640986524282 0.833333333333333 5.5 5 5 absent embryonic telencephalon 0.0789373839811013 0.236147615938652 0.963640986524282 0.833333333333333 5.5 5 5 additional anastomosis between intracranial vertebral arteries 0.0789373839811013 0.236147615938652 0.963640986524282 0.833333333333333 5.5 5 5 abnormal Wolffian duct connection 0.0789373839811013 0.236147615938652 0.963640986524282 0.833333333333333 5.5 5 5 ectopic bone 0.0789373839811013 0.236147615938652 0.963640986524282 0.833333333333333 5.5 5 5 decreased hippocampus volume 0.0789373839811013 0.236147615938652 0.963640986524282 0.833333333333333 5.5 5 5 decreased tear production 0.0789373839811013 0.236147615938652 0.963640986524282 0.833333333333333 5.5 5 5 abnormal excitatory synapse morphology 0.0789373839811013 0.236147615938652 0.963640986524282 0.833333333333333 5.5 5 5 decreased retinal apoptosis 0.0789373839811013 0.236147615938652 0.963640986524282 0.833333333333333 5.5 5 5 abnormal optic nerve morphology 8.46251022094169e-07 1.69080274494719e-05 0.963640986524282 0.833333333333333 5.5 5 5 delayed eyelid opening 3.38842596449851e-05 0.0004483356163133 0.963640986524282 0.833333333333333 5.5 5 5 absent ureter 0.00146070700641137 0.0110423721485736 0.963640986524282 0.833333333333333 5.5 5 5 long tibia 0.00146070700641137 0.0110423721485736 0.963640986524282 0.833333333333333 5.5 5 5 absent inner cell mass 0.00146070700641137 0.0110423721485736 0.963640986524282 0.833333333333333 5.5 5 5 abnormal eye anterior chamber morphology 0.00146070700641137 0.0110423721485736 0.963640986524282 0.833333333333333 5.5 5 5 decreased lactate dehydrogenase level 0.00146070700641137 0.0110423721485736 0.963640986524282 0.833333333333333 5.5 5 5 abnormal pregnancy 0.00146070700641137 0.0110423721485736 0.963640986524282 0.833333333333333 5.5 5 5 increased effector memory CD4-positive, alpha-beta T cell number 0.00146070700641137 0.0110423721485736 0.963640986524282 0.833333333333333 5.5 5 5 abnormal neural tube closure 4.61221558073766e-12 2.39018463689269e-10 0.961318960050729 0.831325301204819 5.5 5 5 reduced long term potentiation 1.01866644415419e-15 9.38493622160569e-14 0.960199411572409 0.830357142857143 5.5 5 5 increased cellular sensitivity to gamma-irradiation 2.45342582695127e-07 5.49810517526243e-06 0.959540386581625 0.829787234042553 5.5 5 5 limb grasping 1.43713096377034e-24 2.46542294646808e-22 0.959405201968131 0.82967032967033 5.5 5 5 thick ventricular wall 1.53031318660311e-06 2.77857959976294e-05 0.958940298785139 0.829268292682927 5.5 5 5 palatal shelves fail to meet at midline 1.53031318660311e-06 2.77857959976294e-05 0.958940298785139 0.829268292682927 5.5 5 5 lethality at weaning, incomplete penetrance 1.53031318660311e-06 2.77857959976294e-05 0.958940298785139 0.829268292682927 5.5 5 5 abnormal liver development 9.63146014465711e-06 0.000149739106936466 0.958134466601286 0.828571428571429 5.5 5 5 abnormal dermal layer morphology 9.63146014465711e-06 0.000149739106936466 0.958134466601286 0.828571428571429 5.5 5 5 abnormal spinal nerve morphology 6.1371225866438e-05 0.000753881107865504 0.956995186617218 0.827586206896552 5.5 5 5 abnormal pulmonary artery morphology 0.000398095010662361 0.00366085522744038 0.95526149968494 0.826086956521739 5.5 5 5 abnormal cranial nerve morphology 0.000398095010662361 0.00366085522744038 0.95526149968494 0.826086956521739 5.5 5 5 abnormal nasal cavity morphology 0.000398095010662361 0.00366085522744038 0.95526149968494 0.826086956521739 5.5 5 5 abnormal cochlear ganglion morphology 0.000398095010662361 0.00366085522744038 0.95526149968494 0.826086956521739 5.5 5 5 dilated heart 0.000398095010662361 0.00366085522744038 0.95526149968494 0.826086956521739 5.5 5 5 abnormal basicranium morphology 0.000398095010662361 0.00366085522744038 0.95526149968494 0.826086956521739 5.5 5 5 abnormal brain morphology 1.81620904952892e-21 2.58161143468753e-19 0.95526149968494 0.826086956521739 5.5 5 5 kidney cysts 1.62708167380986e-10 6.22671640554159e-09 0.953223246129425 0.824324324324324 5.5 5 5 abnormal direction of heart looping 1.73357933996987e-05 0.000249264659432083 0.952304033741643 0.823529411764706 5.5 5 5 abnormal vagus nerve morphology 0.00265519501992483 0.0178749597078837 0.952304033741643 0.823529411764706 5.5 5 5 hyperlipidemia 0.00265519501992483 0.0178749597078837 0.952304033741643 0.823529411764706 5.5 5 5 abnormal tarsal bone morphology 0.00265519501992483 0.0178749597078837 0.952304033741643 0.823529411764706 5.5 5 5 distended abdomen 1.27880954944309e-07 3.08838714003854e-06 0.952304033741643 0.823529411764706 5.5 5 5 abnormal response to novel object 1.27880954944309e-07 3.08838714003854e-06 0.952304033741643 0.823529411764706 5.5 5 5 abnormal myocardial trabeculae morphology 7.91738160895443e-07 1.58826506066727e-05 0.950792440037291 0.822222222222222 5.5 5 5 enhanced long term potentiation 3.71275439924545e-08 9.87751504612093e-07 0.949874686716792 0.821428571428571 5.5 5 5 shortened head 0.000110453779644807 0.00124888080393844 0.949874686716792 0.821428571428571 5.5 5 5 hypoxia 0.000110453779644807 0.00124888080393844 0.949874686716792 0.821428571428571 5.5 5 5 lethality throughout fetal growth and development, complete penetrance 2.2424270054263e-24 3.71869145066528e-22 0.949439961459713 0.821052631578947 5.5 5 5 absent gastric milk in neonates 8.53206455388333e-11 3.42314686738464e-09 0.948815740577754 0.82051282051282 5.5 5 5 increased embryonic tissue cell apoptosis 8.53206455388333e-11 3.42314686738464e-09 0.948815740577754 0.82051282051282 5.5 5 5 short stride length 2.28474245723061e-07 5.14325507905987e-06 0.948222730739893 0.82 5.5 5 5 abnormal axon extension 2.28474245723061e-07 5.14325507905987e-06 0.948222730739893 0.82 5.5 5 5 abnormal erythropoiesis 5.97490769458525e-14 3.96335543740821e-12 0.947121426755294 0.819047619047619 5.5 5 5 abnormal astrocyte morphology 1.41301792240025e-06 2.63287047338624e-05 0.946120241314749 0.818181818181818 5.5 5 5 intestinal inflammation 0.000716398066085512 0.006034178325625 0.946120241314749 0.818181818181818 5.5 5 5 increased coping response 0.000716398066085512 0.006034178325625 0.946120241314749 0.818181818181818 5.5 5 5 abnormal vascular branching morphogenesis 0.000716398066085512 0.006034178325625 0.946120241314749 0.818181818181818 5.5 5 5 abnormal basement membrane morphology 0.000716398066085512 0.006034178325625 0.946120241314749 0.818181818181818 5.5 5 5 premature suture closure 0.0186009922780362 0.0839745341045646 0.946120241314749 0.818181818181818 5.5 5 5 abnormal thrombopoiesis 0.0186009922780362 0.0839745341045646 0.946120241314749 0.818181818181818 5.5 5 5 enlarged cranium 0.0186009922780362 0.0839745341045646 0.946120241314749 0.818181818181818 5.5 5 5 abnormal sebaceous gland morphology 0.0186009922780362 0.0839745341045646 0.946120241314749 0.818181818181818 5.5 5 5 failure of somite differentiation 0.0186009922780362 0.0839745341045646 0.946120241314749 0.818181818181818 5.5 5 5 abnormal fear/anxiety-related behavior 0.0186009922780362 0.0839745341045646 0.946120241314749 0.818181818181818 5.5 5 5 fatigue 0.0186009922780362 0.0839745341045646 0.946120241314749 0.818181818181818 5.5 5 5 patent ductus arteriosus 0.0186009922780362 0.0839745341045646 0.946120241314749 0.818181818181818 5.5 5 5 abnormal spinal cord ventral horn morphology 0.0186009922780362 0.0839745341045646 0.946120241314749 0.818181818181818 5.5 5 5 abnormal pulmonary alveolar sac morphology 0.0186009922780362 0.0839745341045646 0.946120241314749 0.818181818181818 5.5 5 5 decreased embryonic cilium length 0.0186009922780362 0.0839745341045646 0.946120241314749 0.818181818181818 5.5 5 5 hypolactation 0.0186009922780362 0.0839745341045646 0.946120241314749 0.818181818181818 5.5 5 5 reduced sympathetic cervical ganglion size 0.0186009922780362 0.0839745341045646 0.946120241314749 0.818181818181818 5.5 5 5 decreased circulating total protein level 6.61497144739214e-08 1.65374286184804e-06 0.946120241314749 0.818181818181818 5.5 5 5 decreased brown adipose tissue amount 3.10271916287639e-05 0.000414946984820162 0.946120241314749 0.818181818181818 5.5 5 5 increased cardiomyocyte apoptosis 3.10271916287639e-05 0.000414946984820162 0.946120241314749 0.818181818181818 5.5 5 5 abnormal nervous system physiology 5.2081898984996e-15 4.39165165170093e-13 0.94520611547773 0.817391304347826 5.5 5 5 absent kidney 4.06536165689181e-07 8.68033229314882e-06 0.943974843942154 0.816326530612245 5.5 5 5 increased grooming behavior 8.79485985151472e-06 0.000138955939624531 0.943353807860613 0.815789473684211 5.5 5 5 abnormal locomotor behavior 3.83829225785916e-12 2.03143659392014e-10 0.942692269425928 0.815217391304348 5.5 5 5 abnormal trigeminal ganglion morphology 0.000197443757788952 0.00206796356842113 0.942226742379298 0.814814814814815 5.5 5 5 abnormal single cell response 0.000197443757788952 0.00206796356842113 0.942226742379298 0.814814814814815 5.5 5 5 abnormal fetal cardiomyocyte proliferation 0.000197443757788952 0.00206796356842113 0.942226742379298 0.814814814814815 5.5 5 5 abnormal skin appearance 0.000197443757788952 0.00206796356842113 0.942226742379298 0.814814814814815 5.5 5 5 decreased circulating fructosamine level 0.000197443757788952 0.00206796356842113 0.942226742379298 0.814814814814815 5.5 5 5 impaired balance 3.32003300056165e-13 1.89852461813727e-11 0.940967080959004 0.813725490196078 5.5 5 5 abnormal locomotor activation 6.78185029375023e-12 3.40805103145529e-10 0.940344171465453 0.813186813186813 5.5 5 5 abnormal behavior 2.12949482860266e-33 7.06282451486549e-31 0.94006991203376 0.81294964028777 5.5 5 5 increased sacral vertebrae number 9.88233723432932e-09 2.85840858958072e-07 0.939549961861175 0.8125 5.5 5 5 curly tail 7.20303907648858e-07 1.46265793491962e-05 0.939549961861175 0.8125 5.5 5 5 bradykinesia 5.51994048908139e-05 0.000693477372049998 0.939549961861175 0.8125 5.5 5 5 failure of tooth eruption 0.00477709721785993 0.0286338056130761 0.939549961861175 0.8125 5.5 5 5 vasculature congestion 0.00477709721785993 0.0286338056130761 0.939549961861175 0.8125 5.5 5 5 decreased cochlear coiling 0.00477709721785993 0.0286338056130761 0.939549961861175 0.8125 5.5 5 5 decreased circulating growth hormone level 0.00477709721785993 0.0286338056130761 0.939549961861175 0.8125 5.5 5 5 loose skin 0.00477709721785993 0.0286338056130761 0.939549961861175 0.8125 5.5 5 5 decreased circulating triiodothyronine level 0.00477709721785993 0.0286338056130761 0.939549961861175 0.8125 5.5 5 5 decreased liver cholesterol level 0.00477709721785993 0.0286338056130761 0.939549961861175 0.8125 5.5 5 5 embryonic growth arrest 1.2130270239569e-27 2.62383019312417e-25 0.93923435891799 0.812227074235808 5.5 5 5 impaired coordination 4.84817360633004e-41 2.19269669922654e-38 0.93913219842771 0.812138728323699 5.5 5 5 abnormal breathing pattern 1.55909392562402e-05 0.000226136801165584 0.937596635537139 0.810810810810811 5.5 5 5 abnormal calcium ion homeostasis 1.55909392562402e-05 0.000226136801165584 0.937596635537139 0.810810810810811 5.5 5 5 decreased exploration in new environment 7.17454617259793e-11 2.97444726738956e-09 0.936108386909302 0.80952380952381 5.5 5 5 abnormal reproductive system morphology 4.43757738576614e-06 7.3102475146313e-05 0.936108386909302 0.80952380952381 5.5 5 5 spina bifida 4.43757738576614e-06 7.3102475146313e-05 0.936108386909302 0.80952380952381 5.5 5 5 liver degeneration 0.0012782237200039 0.00987447671897423 0.936108386909302 0.80952380952381 5.5 5 5 left pulmonary isomerism 0.0012782237200039 0.00987447671897423 0.936108386909302 0.80952380952381 5.5 5 5 abnormal embryonic/fetal subventricular zone morphology 0.0012782237200039 0.00987447671897423 0.936108386909302 0.80952380952381 5.5 5 5 abnormal cell cycle 2.62099174138382e-14 1.86277627334064e-12 0.93515073127052 0.808695652173913 5.5 5 5 abnormal neural tube morphology 1.43494188293117e-19 1.83047073527759e-17 0.935088660997636 0.808641975308642 5.5 5 5 embryonic lethality between implantation and somite formation, complete penetrance 8.82110598739741e-29 2.30973696248959e-26 0.934535095502732 0.808163265306122 5.5 5 5 abnormal placenta vasculature 3.65530043026494e-07 7.87234616474808e-06 0.933990494631227 0.807692307692308 5.5 5 5 kinked neural tube 3.65530043026494e-07 7.87234616474808e-06 0.933990494631227 0.807692307692308 5.5 5 5 abnormal xiphoid process morphology 0.000350371252234564 0.0033138725852984 0.933990494631227 0.807692307692308 5.5 5 5 decreased circulating glycerol level 0.000350371252234564 0.0033138725852984 0.933990494631227 0.807692307692308 5.5 5 5 abnormal erythrocyte osmotic lysis 0.000350371252234564 0.0033138725852984 0.933990494631227 0.807692307692308 5.5 5 5 abnormal Mullerian duct morphology 0.000350371252234564 0.0033138725852984 0.933990494631227 0.807692307692308 5.5 5 5 decreased bone resorption 0.000350371252234564 0.0033138725852984 0.933990494631227 0.807692307692308 5.5 5 5 abnormal nerve conduction 0.000350371252234564 0.0033138725852984 0.933990494631227 0.807692307692308 5.5 5 5 preweaning lethality, incomplete penetrance 8.92278678133405e-47 5.54885802964211e-44 0.933011810913485 0.806845965770171 5.5 5 5 abnormal postnatal growth/weight/body size 9.7577725362602e-05 0.00113955207436372 0.932555793410595 0.806451612903226 5.5 5 5 abnormal capillary morphology 9.7577725362602e-05 0.00113955207436372 0.932555793410595 0.806451612903226 5.5 5 5 embryonic lethality, complete penetrance 1.68140539056367e-36 6.43460909081096e-34 0.931620314244791 0.80564263322884 5.5 5 5 abnormal pharyngeal arch morphology 2.74822154689766e-05 0.000371532668364561 0.931519620306806 0.805555555555556 5.5 5 5 narrow eye opening 2.74822154689766e-05 0.000371532668364561 0.931519620306806 0.805555555555556 5.5 5 5 decreased embryo size 5.15561308004432e-54 3.66416786760293e-51 0.931385221284975 0.805439330543933 5.5 5 5 embryonic lethality between implantation and placentation, complete penetrance 2.23091982750007e-06 3.96386647921887e-05 0.930123039166915 0.804347826086957 5.5 5 5 embryonic lethality during organogenesis, complete penetrance 2.11376267737298e-62 2.62899232998265e-59 0.929225237005557 0.803571428571429 5.5 5 5 increased neuron apoptosis 3.84578001057872e-10 1.43855304906986e-08 0.927950579615975 0.802469135802469 5.5 5 5 hyperactivity 5.98048168186591e-41 2.47940803060691e-38 0.925718726677235 0.800539083557951 5.5 5 5 decreased cell proliferation 4.66447204774737e-21 6.44604123265088e-19 0.925095347063311 0.8 5.5 5 5 abnormal action potential 7.86781154633698e-09 2.30249190841332e-07 0.92509534706331 0.8 5.5 5 5 abnormal learning/memory/conditioning 3.2247090462306e-07 7.09864048893684e-06 0.92509534706331 0.8 5.5 5 5 lethality at weaning, complete penetrance 3.89813696841956e-06 6.48603057454425e-05 0.92509534706331 0.8 5.5 5 5 impaired behavioral response to xenobiotic 4.81531264198649e-05 0.000611127050864357 0.92509534706331 0.8 5.5 5 5 abnormal brain vasculature morphology 0.00017131909075225 0.00183688033726819 0.92509534706331 0.8 5.5 5 5 abnormal fontanelle morphology 0.00849585905174423 0.0457433969506792 0.92509534706331 0.8 5.5 5 5 interdigital webbing 0.00849585905174423 0.0457433969506792 0.92509534706331 0.8 5.5 5 5 abnormal enteric neuron morphology 0.00849585905174423 0.0457433969506792 0.92509534706331 0.8 5.5 5 5 abnormal prostate gland morphology 0.00849585905174423 0.0457433969506792 0.92509534706331 0.8 5.5 5 5 hyperpigmentation 0.00849585905174423 0.0457433969506792 0.92509534706331 0.8 5.5 5 5 audiogenic seizures 0.00849585905174423 0.0457433969506792 0.92509534706331 0.8 5.5 5 5 abnormal placenta size 0.00849585905174423 0.0457433969506792 0.92509534706331 0.8 5.5 5 5 abnormal trophectoderm morphology 0.00849585905174423 0.0457433969506792 0.92509534706331 0.8 5.5 5 5 immune system phenotype 0.00849585905174423 0.0457433969506792 0.92509534706331 0.8 5.5 5 5 decreased thymocyte apoptosis 0.00849585905174423 0.0457433969506792 0.92509534706331 0.8 5.5 5 5 abnormal egg cylinder morphology 0.000616857084575028 0.00529114482027718 0.92509534706331 0.8 5.5 5 5 abnormal energy expenditure 0.000616857084575028 0.00529114482027718 0.92509534706331 0.8 5.5 5 5 increased liver glycogen level 0.000616857084575028 0.00529114482027718 0.92509534706331 0.8 5.5 5 5 abnormal dopamine level 0.00225935540703656 0.0155682730609513 0.92509534706331 0.8 5.5 5 5 spleen atrophy 0.00225935540703656 0.0155682730609513 0.92509534706331 0.8 5.5 5 5 enhanced behavioral response to xenobiotic 0.00225935540703656 0.0155682730609513 0.92509534706331 0.8 5.5 5 5 increased skin tumor incidence 0.00225935540703656 0.0155682730609513 0.92509534706331 0.8 5.5 5 5 small petrosal ganglion 0.0334400810338096 0.127972617802464 0.92509534706331 0.8 5.5 5 5 enlarged testis 0.0334400810338096 0.127972617802464 0.92509534706331 0.8 5.5 5 5 fused cornea and lens 0.0334400810338096 0.127972617802464 0.92509534706331 0.8 5.5 5 5 abnormal pituitary secretion 0.0334400810338096 0.127972617802464 0.92509534706331 0.8 5.5 5 5 abnormal immune cell physiology 0.0334400810338096 0.127972617802464 0.92509534706331 0.8 5.5 5 5 ketoaciduria 0.0334400810338096 0.127972617802464 0.92509534706331 0.8 5.5 5 5 abnormal PNS synaptic transmission 0.0334400810338096 0.127972617802464 0.92509534706331 0.8 5.5 5 5 abnormal tibialis anterior morphology 0.0334400810338096 0.127972617802464 0.92509534706331 0.8 5.5 5 5 peritoneal inflammation 0.0334400810338096 0.127972617802464 0.92509534706331 0.8 5.5 5 5 cochlear ganglion hypoplasia 0.0334400810338096 0.127972617802464 0.92509534706331 0.8 5.5 5 5 absent seminal vesicle 0.0334400810338096 0.127972617802464 0.92509534706331 0.8 5.5 5 5 abnormal plasma membrane morphology 0.0334400810338096 0.127972617802464 0.92509534706331 0.8 5.5 5 5 abnormal embryonic erythrocyte morphology 0.0334400810338096 0.127972617802464 0.92509534706331 0.8 5.5 5 5 abnormal utricular macula morphology 0.0334400810338096 0.127972617802464 0.92509534706331 0.8 5.5 5 5 abnormal corneal endothelium morphology 0.0334400810338096 0.127972617802464 0.92509534706331 0.8 5.5 5 5 decreased thyroxine level 0.0334400810338096 0.127972617802464 0.92509534706331 0.8 5.5 5 5 vascular smooth muscle hyperplasia 0.0334400810338096 0.127972617802464 0.92509534706331 0.8 5.5 5 5 absent inguinal lymph nodes 0.0334400810338096 0.127972617802464 0.92509534706331 0.8 5.5 5 5 decreased transitional stage T2 B cell number 0.0334400810338096 0.127972617802464 0.92509534706331 0.8 5.5 5 5 abnormal hippocampus neuron morphology 0.0334400810338096 0.127972617802464 0.92509534706331 0.8 5.5 5 5 increased kidney iron level 0.0334400810338096 0.127972617802464 0.92509534706331 0.8 5.5 5 5 aorta stenosis 0.0334400810338096 0.127972617802464 0.92509534706331 0.8 5.5 5 5 thin ventricle myocardium compact layer 0.0334400810338096 0.127972617802464 0.92509534706331 0.8 5.5 5 5 thick aortic valve cusps 0.0334400810338096 0.127972617802464 0.92509534706331 0.8 5.5 5 5 abnormal pulmonary interalveolar septum morphology 0.0334400810338096 0.127972617802464 0.92509534706331 0.8 5.5 5 5 lethality throughout fetal growth and development, incomplete penetrance 2.74292011163606e-20 3.59105988299721e-18 0.92380331445568 0.798882681564246 5.5 5 5 abnormal motor coordination/ balance 8.53889125810457e-12 4.18096698421275e-10 0.922759247702039 0.797979797979798 5.5 5 5 decreased rib number 9.93395878643517e-11 3.9223369017869e-09 0.922496764627739 0.797752808988764 5.5 5 5 abnormal nervous system morphology 1.16105859447005e-09 3.95278596955282e-08 0.922167830142224 0.79746835443038 5.5 5 5 decreased anxiety-related response 3.2451126419087e-14 2.24228269354108e-12 0.921334796871996 0.796747967479675 5.5 5 5 axon degeneration 5.60098570279325e-07 1.16589555947265e-05 0.920812498234314 0.796296296296296 5.5 5 5 hemorrhage 1.07146869283451e-25 1.90377026673275e-23 0.920174627132123 0.795744680851064 5.5 5 5 decreased startle reflex 1.90395686759742e-13 1.14122715859002e-11 0.9191652486847 0.794871794871795 5.5 5 5 abnormal iris morphology 2.37533142091184e-05 0.000325544733306788 0.9191652486847 0.794871794871795 5.5 5 5 failure of heart looping 2.37533142091184e-05 0.000325544733306788 0.9191652486847 0.794871794871795 5.5 5 5 abnormal embryo development 2.47285556259985e-15 2.15832568840952e-13 0.918293175393727 0.794117647058823 5.5 5 5 overexpanded pulmonary alveoli 8.38368705123017e-05 0.000997819212437084 0.918293175393727 0.794117647058823 5.5 5 5 lordosis 0.000298603569128555 0.00291284854198934 0.917120387174834 0.793103448275862 5.5 5 5 increased mortality induced by gamma-irradiation 0.000298603569128555 0.00291284854198934 0.917120387174834 0.793103448275862 5.5 5 5 enlarged kidney 9.6857213038891e-07 1.87458341074696e-05 0.916368032468374 0.792452830188679 5.5 5 5 atrioventricular septal defect 9.6857213038891e-07 1.87458341074696e-05 0.916368032468374 0.792452830188679 5.5 5 5 neonatal lethality, incomplete penetrance 1.07730824267027e-27 2.43618568512937e-25 0.916200199495394 0.792307692307692 5.5 5 5 abnormal spatial learning 8.3191784772627e-18 8.99737237486564e-16 0.915163341803428 0.791411042944785 5.5 5 5 increased grip strength 1.49511329078902e-10 5.76603769122121e-09 0.914929464128549 0.791208791208791 5.5 5 5 abnormal vasculogenesis 1.17189233390364e-05 0.000175080010845964 0.914338424423039 0.790697674418605 5.5 5 5 prenatal lethality 1.39926223723687e-07 3.29920835557035e-06 0.913904677542383 0.790322580645161 5.5 5 5 decreased birth body size 9.67943376789059e-13 5.35057588836174e-11 0.912923039865109 0.789473684210526 5.5 5 5 incomplete embryo turning 4.8230673655948e-07 1.00818319932076e-05 0.912923039865109 0.789473684210526 5.5 5 5 impaired branching involved in ureteric bud morphogenesis 4.10762370239615e-05 0.000531712926589462 0.912923039865109 0.789473684210526 5.5 5 5 decreased total retina thickness 4.10762370239615e-05 0.000531712926589462 0.912923039865109 0.789473684210526 5.5 5 5 small superior vagus ganglion 0.00395251765006797 0.0246104822391591 0.912923039865109 0.789473684210526 5.5 5 5 stereotypic behavior 0.00395251765006797 0.0246104822391591 0.912923039865109 0.789473684210526 5.5 5 5 decreased chemically-elicited antinociception 0.00395251765006797 0.0246104822391591 0.912923039865109 0.789473684210526 5.5 5 5 abnormal photoreceptor inner segment morphology 0.00395251765006797 0.0246104822391591 0.912923039865109 0.789473684210526 5.5 5 5 eyelids fail to open 0.00395251765006797 0.0246104822391591 0.912923039865109 0.789473684210526 5.5 5 5 increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 0.00395251765006797 0.0246104822391591 0.912923039865109 0.789473684210526 5.5 5 5 increased bone mineral content 3.28594637476e-12 1.75780464671301e-10 0.912364677149595 0.788990825688073 5.5 5 5 distended pericardium 1.66731078250388e-06 3.0053880952742e-05 0.911752625711436 0.788461538461538 5.5 5 5 belly spot 0.000144981911292713 0.00157142703416393 0.911078750895685 0.787878787878788 5.5 5 5 single kidney 0.000144981911292713 0.00157142703416393 0.911078750895685 0.787878787878788 5.5 5 5 abnormal social investigation 2.98376497589788e-09 9.51553253531534e-08 0.910640732265446 0.7875 5.5 5 5 ventricular septal defect 1.08420459874147e-14 8.2983351980597e-13 0.909790460806748 0.786764705882353 5.5 5 5 increased startle reflex 4.38961800672649e-10 1.61765552470106e-08 0.909503852449884 0.786516853932584 5.5 5 5 myoclonus 0.00051640701098415 0.00451515796071379 0.908575787294323 0.785714285714286 5.5 5 5 translucent skin 0.0149127279544951 0.0697938114521289 0.908575787294323 0.785714285714286 5.5 5 5 increased lactate dehydrogenase level 0.0149127279544951 0.0697938114521289 0.908575787294323 0.785714285714286 5.5 5 5 failure of zygotic cell division 0.0149127279544951 0.0697938114521289 0.908575787294323 0.785714285714286 5.5 5 5 abnormal voluntary movement 0.0149127279544951 0.0697938114521289 0.908575787294323 0.785714285714286 5.5 5 5 abnormal decidualization 0.0149127279544951 0.0697938114521289 0.908575787294323 0.785714285714286 5.5 5 5 abnormal maternal decidual layer morphology 0.0149127279544951 0.0697938114521289 0.908575787294323 0.785714285714286 5.5 5 5 decreased CNS synapse formation 0.0149127279544951 0.0697938114521289 0.908575787294323 0.785714285714286 5.5 5 5 abnormal viscerocranium morphology 0.0149127279544951 0.0697938114521289 0.908575787294323 0.785714285714286 5.5 5 5 spina bifida occulta 0.0149127279544951 0.0697938114521289 0.908575787294323 0.785714285714286 5.5 5 5 sternebra fusion 0.0149127279544951 0.0697938114521289 0.908575787294323 0.785714285714286 5.5 5 5 increased stomach tumor incidence 0.0149127279544951 0.0697938114521289 0.908575787294323 0.785714285714286 5.5 5 5 abnormal pancreas morphology 2.01523721872634e-05 0.000282417046849678 0.908575787294323 0.785714285714286 5.5 5 5 abnormal somite development 5.09784847828775e-09 1.54645098655375e-07 0.907530245536792 0.784810126582278 5.5 5 5 small lung 2.85651878241807e-06 4.901290262742e-05 0.906956222611089 0.784313725490196 5.5 5 5 abnormal trophoblast layer morphology 2.85651878241807e-06 4.901290262742e-05 0.906956222611089 0.784313725490196 5.5 5 5 abnormal eye morphology 9.31811711656092e-15 7.24338010232665e-13 0.906793100988317 0.784172661870504 5.5 5 5 abnormal vocalization 7.05880917401454e-05 0.000850304494932744 0.906343414352568 0.783783783783784 5.5 5 5 impaired skeletal muscle contractility 7.05880917401454e-05 0.000850304494932744 0.906343414352568 0.783783783783784 5.5 5 5 abnormal eating behavior 4.10253582263108e-07 8.68515562450622e-06 0.905822527332825 0.783333333333333 5.5 5 5 absent mesoderm 4.10253582263108e-07 8.68515562450622e-06 0.905822527332825 0.783333333333333 5.5 5 5 pale yolk sac 2.54861206898799e-09 8.28715362301651e-08 0.90559032468547 0.783132530120482 5.5 5 5 embryonic lethality during organogenesis, incomplete penetrance 3.02526894224349e-23 4.85506870569721e-21 0.904984578648891 0.782608695652174 5.5 5 5 abnormal cell death 9.90011867572961e-06 0.000152015711147391 0.904984578648891 0.782608695652174 5.5 5 5 abnormal myelin sheath morphology 9.90011867572961e-06 0.000152015711147391 0.904984578648891 0.782608695652174 5.5 5 5 atrial septal defect 9.90011867572961e-06 0.000152015711147391 0.904984578648891 0.782608695652174 5.5 5 5 abnormal Wolffian duct morphology 0.00186228906560886 0.0134079422596297 0.904984578648891 0.782608695652174 5.5 5 5 abnormal hematopoietic stem cell physiology 0.00186228906560886 0.0134079422596297 0.904984578648891 0.782608695652174 5.5 5 5 decreased effector memory CD8-positive, alpha-beta T cell number 0.00186228906560886 0.0134079422596297 0.904984578648891 0.782608695652174 5.5 5 5 microcephaly 5.94729406421062e-08 1.49433272572969e-06 0.904984578648891 0.782608695652174 5.5 5 5 decreased spleen weight 5.94729406421062e-08 1.49433272572969e-06 0.904984578648891 0.782608695652174 5.5 5 5 abnormal embryo turning 1.41159770554762e-06 2.63287047338624e-05 0.904070452811872 0.781818181818182 5.5 5 5 abnormal auditory brainstem response waveform shape 0.000248928869904704 0.00248180586728637 0.903413424866514 0.78125 5.5 5 5 decreased grip strength 5.83596072620816e-22 8.53938370967224e-20 0.902918403811793 0.780821917808219 5.5 5 5 abnormal developmental patterning 4.33046643752791e-09 1.33814102650319e-07 0.902532045915425 0.780487804878049 5.5 5 5 abnormal motor capabilities/coordination/movement 9.07227782913303e-14 5.93876081578116e-12 0.902318378290918 0.78030303030303 5.5 5 5 prenatal lethality, incomplete penetrance 1.07039338581524e-29 2.95844838579489e-27 0.901511501866795 0.779605263157895 5.5 5 5 pericardial edema 1.01043711614341e-07 2.47631756296231e-06 0.901287746219769 0.779411764705882 5.5 5 5 abnormal apoptosis 2.39822959077243e-06 4.22805652634868e-05 0.89939825408933 0.777777777777778 5.5 5 5 abnormal neuronal precursor proliferation 2.39822959077243e-06 4.22805652634868e-05 0.89939825408933 0.777777777777778 5.5 5 5 abnormal atrioventricular cushion morphology 0.000885617482794212 0.00711784648933958 0.89939825408933 0.777777777777778 5.5 5 5 decreased susceptibility to pharmacologically induced seizures 0.000885617482794212 0.00711784648933958 0.89939825408933 0.777777777777778 5.5 5 5 abnormal eye muscle morphology 0.000885617482794212 0.00711784648933958 0.89939825408933 0.777777777777778 5.5 5 5 increased exploration in new environment 7.33414232588934e-09 2.15901527049109e-07 0.89939825408933 0.777777777777778 5.5 5 5 hydrops fetalis 5.01692381637172e-08 1.30676418777221e-06 0.89939825408933 0.777777777777778 5.5 5 5 abnormal reflex 0.000120501314747973 0.00134717761993521 0.89939825408933 0.777777777777778 5.5 5 5 abnormal megakaryocyte differentiation 0.00683590306722191 0.0377454137174573 0.89939825408933 0.777777777777778 5.5 5 5 underdeveloped hair follicles 0.00683590306722191 0.0377454137174573 0.89939825408933 0.777777777777778 5.5 5 5 abnormal phrenic nerve morphology 0.00683590306722191 0.0377454137174573 0.89939825408933 0.777777777777778 5.5 5 5 abnormal thymus medulla morphology 0.00683590306722191 0.0377454137174573 0.89939825408933 0.777777777777778 5.5 5 5 abnormal bile duct morphology 0.00683590306722191 0.0377454137174573 0.89939825408933 0.777777777777778 5.5 5 5 decreased cellular sensitivity to gamma-irradiation 0.00683590306722191 0.0377454137174573 0.89939825408933 0.777777777777778 5.5 5 5 abnormal body wall morphology 0.00683590306722191 0.0377454137174573 0.89939825408933 0.777777777777778 5.5 5 5 increased circulating glycerol level 0.00683590306722191 0.0377454137174573 0.89939825408933 0.777777777777778 5.5 5 5 abnormal anterior eye segment morphology 0.00683590306722191 0.0377454137174573 0.89939825408933 0.777777777777778 5.5 5 5 decreased tumor latency 0.00683590306722191 0.0377454137174573 0.89939825408933 0.777777777777778 5.5 5 5 heart hyperplasia 0.059042770054518 0.189875747266469 0.89939825408933 0.777777777777778 5.5 5 5 small nodose ganglion 0.059042770054518 0.189875747266469 0.89939825408933 0.777777777777778 5.5 5 5 dilated uterus 0.059042770054518 0.189875747266469 0.89939825408933 0.777777777777778 5.5 5 5 abnormal vomeronasal organ morphology 0.059042770054518 0.189875747266469 0.89939825408933 0.777777777777778 5.5 5 5 abnormal gut-associated lymphoid tissue morphology 0.059042770054518 0.189875747266469 0.89939825408933 0.777777777777778 5.5 5 5 polycythemia 0.059042770054518 0.189875747266469 0.89939825408933 0.777777777777778 5.5 5 5 decreased circulating bicarbonate level 0.059042770054518 0.189875747266469 0.89939825408933 0.777777777777778 5.5 5 5 abnormal artery development 0.059042770054518 0.189875747266469 0.89939825408933 0.777777777777778 5.5 5 5 premature neuronal precursor differentiation 0.059042770054518 0.189875747266469 0.89939825408933 0.777777777777778 5.5 5 5 abnormal proprioceptive neuron morphology 0.059042770054518 0.189875747266469 0.89939825408933 0.777777777777778 5.5 5 5 small scapula 0.059042770054518 0.189875747266469 0.89939825408933 0.777777777777778 5.5 5 5 decreased thyroid-stimulating hormone level 0.059042770054518 0.189875747266469 0.89939825408933 0.777777777777778 5.5 5 5 abnormal posterior eye segment morphology 0.059042770054518 0.189875747266469 0.89939825408933 0.777777777777778 5.5 5 5 abnormal intervertebral disk development 0.059042770054518 0.189875747266469 0.89939825408933 0.777777777777778 5.5 5 5 abnormal inguinal fat pad morphology 0.059042770054518 0.189875747266469 0.89939825408933 0.777777777777778 5.5 5 5 decreased susceptibility to atherosclerosis 0.059042770054518 0.189875747266469 0.89939825408933 0.777777777777778 5.5 5 5 abnormal liver vasculature morphology 0.059042770054518 0.189875747266469 0.89939825408933 0.777777777777778 5.5 5 5 decreased transitional stage T1 B cell number 0.059042770054518 0.189875747266469 0.89939825408933 0.777777777777778 5.5 5 5 abnormal hippocampus granule cell morphology 0.059042770054518 0.189875747266469 0.89939825408933 0.777777777777778 5.5 5 5 abnormal telomere morphology 0.059042770054518 0.189875747266469 0.89939825408933 0.777777777777778 5.5 5 5 abnormal pulmonary alveolar system morphology 0.059042770054518 0.189875747266469 0.89939825408933 0.777777777777778 5.5 5 5 abnormal oxidative phosphorylation 0.059042770054518 0.189875747266469 0.89939825408933 0.777777777777778 5.5 5 5 abnormal lung lobe morphology 0.059042770054518 0.189875747266469 0.89939825408933 0.777777777777778 5.5 5 5 abnormal ureteric bud invasion 0.059042770054518 0.189875747266469 0.89939825408933 0.777777777777778 5.5 5 5 increased core body temperature 0.059042770054518 0.189875747266469 0.89939825408933 0.777777777777778 5.5 5 5 decreased pancreatic beta cell proliferation 0.059042770054518 0.189875747266469 0.89939825408933 0.777777777777778 5.5 5 5 decreased bone trabecular spacing 0.059042770054518 0.189875747266469 0.89939825408933 0.777777777777778 5.5 5 5 trigeminal neuroma 0.059042770054518 0.189875747266469 0.89939825408933 0.777777777777778 5.5 5 5 cerebellum atrophy 0.059042770054518 0.189875747266469 0.89939825408933 0.777777777777778 5.5 5 5 increased endoplasmic reticulum stress 0.059042770054518 0.189875747266469 0.89939825408933 0.777777777777778 5.5 5 5 decreased body length 1.56859976796024e-26 3.00145532523161e-24 0.89892932903506 0.777372262773723 5.5 5 5 hypoactivity 6.14029360201634e-36 2.18199719071652e-33 0.898716633586041 0.777188328912467 5.5 5 5 increased anxiety-related response 3.85807625100679e-14 2.59377423631876e-12 0.898473898226956 0.776978417266187 5.5 5 5 abnormal embryonic neuroepithelium morphology 1.18236368196761e-06 2.24513714419422e-05 0.897182987453642 0.775862068965517 5.5 5 5 thrombocytosis 1.18236368196761e-06 2.24513714419422e-05 0.897182987453642 0.775862068965517 5.5 5 5 double outlet right ventricle 3.96399752708695e-11 1.729902429584e-09 0.896996656615126 0.775700934579439 5.5 5 5 abnormal craniofacial development 8.25915724498187e-06 0.000131275742152667 0.896776101745046 0.775510204081633 5.5 5 5 head bobbing 5.85382135500523e-05 0.000723624671418141 0.896186117467582 0.775 5.5 5 5 perinatal lethality 5.85382135500523e-05 0.000723624671418141 0.896186117467582 0.775 5.5 5 5 abnormal extraembryonic tissue morphology 1.33706537983921e-10 5.23771674385834e-09 0.89561926982845 0.774509803921569 5.5 5 5 abnormal mitochondrial ATP synthesis coupled electron transport 0.00042414662923104 0.00383771641198662 0.895253561674171 0.774193548387097 5.5 5 5 abnormal testis morphology 9.88805085753471e-12 4.77602456468303e-10 0.894929194441681 0.773913043478261 5.5 5 5 increased circulating bilirubin level 4.05466784389669e-06 6.72399084112868e-05 0.894549745981031 0.773584905660377 5.5 5 5 prenatal lethality, complete penetrance 3.17382186674179e-26 5.84806066186682e-24 0.894314296846276 0.773381294964029 5.5 5 5 abnormal tail movements 0.0031884309433264 0.0203104275839294 0.893558005686152 0.772727272727273 5.5 5 5 abnormal oogenesis 0.0031884309433264 0.0203104275839294 0.893558005686152 0.772727272727273 5.5 5 5 testis hypoplasia 0.0031884309433264 0.0203104275839294 0.893558005686152 0.772727272727273 5.5 5 5 increased skin papilloma incidence 0.0031884309433264 0.0203104275839294 0.893558005686152 0.772727272727273 5.5 5 5 abnormal lysosome physiology 0.0031884309433264 0.0203104275839294 0.893558005686152 0.772727272727273 5.5 5 5 abnormal blood-brain barrier function 0.0031884309433264 0.0203104275839294 0.893558005686152 0.772727272727273 5.5 5 5 abnormal cerebral cortex pyramidal cell morphology 0.0031884309433264 0.0203104275839294 0.893558005686152 0.772727272727273 5.5 5 5 pulmonary vascular congestion 0.0031884309433264 0.0203104275839294 0.893558005686152 0.772727272727273 5.5 5 5 increased adenoma incidence 0.0031884309433264 0.0203104275839294 0.893558005686152 0.772727272727273 5.5 5 5 increased bone volume 0.0031884309433264 0.0203104275839294 0.893558005686152 0.772727272727273 5.5 5 5 abnormal placenta morphology 2.08246037749789e-08 5.88650021480228e-07 0.89289266093136 0.772151898734177 5.5 5 5 pallor 7.63737724520265e-17 7.73361328894105e-15 0.892056227525335 0.771428571428571 5.5 5 5 abnormal embryonic epiblast morphology 0.000204269506824278 0.00212158830156739 0.892056227525335 0.771428571428571 5.5 5 5 holoprosencephaly 0.000204269506824278 0.00212158830156739 0.892056227525335 0.771428571428571 5.5 5 5 decreased circulating thyroxine level 0.000204269506824278 0.00212158830156739 0.892056227525335 0.771428571428571 5.5 5 5 small heart 1.39323594462216e-05 0.000205069491848972 0.891367912534961 0.770833333333333 5.5 5 5 short limbs 5.12894192110275e-09 1.54645370045371e-07 0.890537187546578 0.770114942528736 5.5 5 5 small liver 3.49067216022139e-08 9.38707783627103e-07 0.889514756791645 0.769230769230769 5.5 5 5 no spontaneous movement 0.00150514319237656 0.0112602817775539 0.889514756791645 0.769230769230769 5.5 5 5 short premaxilla 0.0257871908064364 0.104301848993513 0.889514756791645 0.769230769230769 5.5 5 5 absent teeth 0.0257871908064364 0.104301848993513 0.889514756791645 0.769230769230769 5.5 5 5 short hair 0.0257871908064364 0.104301848993513 0.889514756791645 0.769230769230769 5.5 5 5 excessive scratching 0.0257871908064364 0.104301848993513 0.889514756791645 0.769230769230769 5.5 5 5 abnormal pulmonary alveolus epithelial cell morphology 0.0257871908064364 0.104301848993513 0.889514756791645 0.769230769230769 5.5 5 5 abnormal bile duct development 0.0257871908064364 0.104301848993513 0.889514756791645 0.769230769230769 5.5 5 5 abnormal telomere length 0.0257871908064364 0.104301848993513 0.889514756791645 0.769230769230769 5.5 5 5 abnormal dopaminergic neuron morphology 0.0257871908064364 0.104301848993513 0.889514756791645 0.769230769230769 5.5 5 5 hyperalgesia 0.0257871908064364 0.104301848993513 0.889514756791645 0.769230769230769 5.5 5 5 increased prostaglandin level 0.0257871908064364 0.104301848993513 0.889514756791645 0.769230769230769 5.5 5 5 abnormal coat/hair pigmentation 4.6415425847911e-11 2.0079716834205e-09 0.887926337583088 0.767857142857143 5.5 5 5 abnormal eye development 3.34532422504417e-06 5.64169085409991e-05 0.887926337583088 0.767857142857143 5.5 5 5 decreased circulating serum albumin level 6.28805392517046e-10 2.21865732466121e-08 0.887717757282975 0.767676767676768 5.5 5 5 abnormal bone structure 6.64942378600947e-18 7.35130740786602e-16 0.886749425941515 0.766839378238342 5.5 5 5 abnormal lactation 0.000716823998079271 0.006034178325625 0.886549707602339 0.766666666666667 5.5 5 5 liver hemorrhage 0.000716823998079271 0.006034178325625 0.886549707602339 0.766666666666667 5.5 5 5 decreased total body fat amount 7.492432465598e-30 2.19263832449118e-27 0.886318895389998 0.766467065868264 5.5 5 5 pulmonary hypoplasia 2.33706182879917e-05 0.000322074310201547 0.885729587613808 0.765957446808511 5.5 5 5 abnormal heart development 7.92366621470618e-15 6.35810313196181e-13 0.885573868628644 0.765822784810127 5.5 5 5 increased circulating alkaline phosphatase level 3.95416959203241e-15 3.39172305523469e-13 0.885122091326007 0.765432098765432 5.5 5 5 decreased heart weight 2.88441157738403e-08 7.92814784391468e-07 0.885122091326007 0.765432098765432 5.5 5 5 perinatal lethality, complete penetrance 2.06682143839164e-19 2.5706091639996e-17 0.884921018611031 0.765258215962441 5.5 5 5 abnormal nervous system development 0.000343703293829048 0.00328831516692214 0.884282317045812 0.764705882352941 5.5 5 5 abnormal interatrial septum morphology 0.011673279361149 0.0563283848901223 0.884282317045812 0.764705882352941 5.5 5 5 increased incidence of corneal inflammation 0.011673279361149 0.0563283848901223 0.884282317045812 0.764705882352941 5.5 5 5 abnormal ectoplacental cone morphology 0.011673279361149 0.0563283848901223 0.884282317045812 0.764705882352941 5.5 5 5 decreased growth hormone level 0.011673279361149 0.0563283848901223 0.884282317045812 0.764705882352941 5.5 5 5 increased brain size 0.011673279361149 0.0563283848901223 0.884282317045812 0.764705882352941 5.5 5 5 coloboma 0.011673279361149 0.0563283848901223 0.884282317045812 0.764705882352941 5.5 5 5 increased trabecular bone mass 0.011673279361149 0.0563283848901223 0.884282317045812 0.764705882352941 5.5 5 5 anophthalmia 7.07521847747929e-09 2.10773724104548e-07 0.883518028094173 0.764044943820225 5.5 5 5 abnormal neuromuscular synapse morphology 1.9648060469531e-07 4.48390370806958e-06 0.883337570980592 0.763888888888889 5.5 5 5 abnormal gait 3.09656948246956e-27 6.41893048970252e-25 0.883181642018371 0.763754045307443 5.5 5 5 decreased hair follicle number 0.000165681845825627 0.00178027469326673 0.882492271869605 0.763157894736842 5.5 5 5 abnormal pulmonary alveolus morphology 8.63206488689636e-10 3.02426216988094e-08 0.881588387671719 0.762376237623762 5.5 5 5 abnormal embryonic tissue morphology 1.45420139059841e-13 8.93166903484826e-12 0.881043187679343 0.761904761904762 5.5 5 5 abnormal scapula morphology 0.0053989768055411 0.0315998936559611 0.881043187679343 0.761904761904762 5.5 5 5 abnormal eye pigmentation 0.0053989768055411 0.0315998936559611 0.881043187679343 0.761904761904762 5.5 5 5 complete atrioventricular septal defect 0.0053989768055411 0.0315998936559611 0.881043187679343 0.761904761904762 5.5 5 5 embryonic lethality at implantation, complete penetrance 0.0053989768055411 0.0315998936559611 0.881043187679343 0.761904761904762 5.5 5 5 decreased vocalization 0.0053989768055411 0.0315998936559611 0.881043187679343 0.761904761904762 5.5 5 5 increased muscle cell glucose uptake 0.0053989768055411 0.0315998936559611 0.881043187679343 0.761904761904762 5.5 5 5 rib fusion 6.61913809444236e-07 1.36076419684549e-05 0.88022131903412 0.761194029850746 5.5 5 5 decreased white adipose tissue amount 6.61913809444236e-07 1.36076419684549e-05 0.88022131903412 0.761194029850746 5.5 5 5 abnormal skeletal muscle fiber morphology 3.26046893416538e-07 7.14574138655189e-06 0.879492055306668 0.76056338028169 5.5 5 5 increased B cell derived lymphoma incidence 1.89922556923974e-05 0.000266910938049935 0.878840579710145 0.76 5.5 5 5 abnormal inner ear vestibule morphology 0.00253323274602504 0.0171234142818948 0.878840579710145 0.76 5.5 5 5 abnormal thyroid gland morphology 0.00253323274602504 0.0171234142818948 0.878840579710145 0.76 5.5 5 5 impaired limb coordination 9.27881925759632e-06 0.00014608267660298 0.877984009944346 0.759259259259259 5.5 5 5 abnormal outer ear morphology 0.00120093211395888 0.00939408375305886 0.87724558773245 0.758620689655172 5.5 5 5 impaired righting response 4.75379312946801e-09 1.45988400117922e-07 0.876406118270505 0.757894736842105 5.5 5 5 abnormal tooth development 0.000573763115567174 0.00497294686401863 0.87603726047662 0.757575757575758 5.5 5 5 enlarged pericardium 0.000573763115567174 0.00497294686401863 0.87603726047662 0.757575757575758 5.5 5 5 abnormal craniofacial morphology 1.16795886939551e-09 3.95278596955282e-08 0.875697051831774 0.757281553398058 5.5 5 5 infertility 5.79374303837478e-10 2.07365982848306e-08 0.875382279347292 0.757009345794392 5.5 5 5 increased erythroid progenitor cell number 0.000275786897438996 0.00272771334942148 0.875090193167996 0.756756756756757 5.5 5 5 perinatal lethality, incomplete penetrance 2.14547308681047e-19 2.60334844070294e-17 0.874951904578684 0.756637168141593 5.5 5 5 hydroencephaly 1.42757636770362e-10 5.54858783541056e-09 0.874818426027261 0.756521739130435 5.5 5 5 liver fibrosis 0.000133203993825841 0.00145966931560255 0.874327919480568 0.75609756097561 5.5 5 5 hemopericardium 0.000133203993825841 0.00145966931560255 0.874327919480568 0.75609756097561 5.5 5 5 oxidative stress 1.58018078220701e-08 4.49222822370279e-07 0.873701161115349 0.755555555555556 5.5 5 5 abnormal ectoderm development 6.45921524014934e-05 0.000785686939358019 0.873701161115349 0.755555555555556 5.5 5 5 increased circulating corticosterone level 6.45921524014934e-05 0.000785686939358019 0.873701161115349 0.755555555555556 5.5 5 5 postnatal lethality, incomplete penetrance 3.13806335193795e-46 1.73465168621015e-43 0.873384471589261 0.755281690140845 5.5 5 5 organ of Corti degeneration 3.14247329000439e-05 0.000418016166250584 0.873176730646492 0.755102040816326 5.5 5 5 respiratory failure 2.65264203942327e-13 1.53452257513149e-11 0.873020443420674 0.754966887417219 5.5 5 5 abnormal mesoderm development 1.53309380792661e-05 0.00022366984441158 0.872731459493689 0.754716981132076 5.5 5 5 abnormal sternum morphology 8.86629601782088e-07 1.7503897892325e-05 0.871466631291524 0.753623188405797 5.5 5 5 cardiac fibrosis 5.24403974313199e-08 1.35880717302509e-06 0.870677973706645 0.752941176470588 5.5 5 5 decreased erythrocyte cell number 1.75861287884859e-13 1.06696330149655e-11 0.869118240075403 0.751592356687898 5.5 5 5 small kidney 4.2381297980883e-08 1.12152636944092e-06 0.867276887871854 0.75 5.5 5 5 decreased blood urea nitrogen level 0.000106364940268859 0.00121647259273005 0.867276887871854 0.75 5.5 5 5 abnormal spermatogenesis 2.17633075644086e-15 1.93343669880237e-13 0.867276887871854 0.75 5.5 5 5 edema 1.76168468510881e-14 1.28887960417887e-12 0.867276887871854 0.75 5.5 5 5 abnormal digit morphology 7.14745759580227e-07 1.45731973520968e-05 0.867276887871854 0.75 5.5 5 5 eyelids open at birth 2.51895009817876e-05 0.000344279580726355 0.867276887871854 0.75 5.5 5 5 overriding aortic valve 5.16853948133015e-05 0.000650974276446012 0.867276887871854 0.75 5.5 5 5 thymus atrophy 5.16853948133015e-05 0.000650974276446012 0.867276887871854 0.75 5.5 5 5 heart right ventricle hypertrophy 0.000455574083053185 0.00403718933860632 0.867276887871854 0.75 5.5 5 5 failure of primitive streak formation 0.00094979990721005 0.00758467823173355 0.867276887871854 0.75 5.5 5 5 abnormal spongiotrophoblast layer morphology 0.00094979990721005 0.00758467823173355 0.867276887871854 0.75 5.5 5 5 rib bifurcation 0.0019932488982244 0.0141058510222851 0.867276887871854 0.75 5.5 5 5 small superior cervical ganglion 0.0019932488982244 0.0141058510222851 0.867276887871854 0.75 5.5 5 5 increased bone resorption 0.0019932488982244 0.0141058510222851 0.867276887871854 0.75 5.5 5 5 abnormal brainstem morphology 0.0019932488982244 0.0141058510222851 0.867276887871854 0.75 5.5 5 5 abnormal digestive system morphology 0.00421879453246635 0.0260080579913508 0.867276887871854 0.75 5.5 5 5 hemolytic anemia 0.00421879453246635 0.0260080579913508 0.867276887871854 0.75 5.5 5 5 apnea 0.00421879453246635 0.0260080579913508 0.867276887871854 0.75 5.5 5 5 abnormal sensory capabilities/reflexes/nociception 0.00421879453246635 0.0260080579913508 0.867276887871854 0.75 5.5 5 5 abnormal truncus arteriosus septation 0.00421879453246635 0.0260080579913508 0.867276887871854 0.75 5.5 5 5 abnormal tympanic ring morphology 0.0196521445533971 0.0876070064096332 0.867276887871854 0.75 5.5 5 5 absent mandible 0.0196521445533971 0.0876070064096332 0.867276887871854 0.75 5.5 5 5 disorganized yolk sac vascular plexus 0.0196521445533971 0.0876070064096332 0.867276887871854 0.75 5.5 5 5 abnormal meiosis 0.0196521445533971 0.0876070064096332 0.867276887871854 0.75 5.5 5 5 abnormal olfaction 0.0196521445533971 0.0876070064096332 0.867276887871854 0.75 5.5 5 5 impaired muscle relaxation 0.0196521445533971 0.0876070064096332 0.867276887871854 0.75 5.5 5 5 blepharitis 0.0196521445533971 0.0876070064096332 0.867276887871854 0.75 5.5 5 5 decreased creatinine clearance 0.0196521445533971 0.0876070064096332 0.867276887871854 0.75 5.5 5 5 decreased skeletal muscle weight 0.0196521445533971 0.0876070064096332 0.867276887871854 0.75 5.5 5 5 abnormal pulmonary alveolus wall morphology 0.0196521445533971 0.0876070064096332 0.867276887871854 0.75 5.5 5 5 embryonic lethality between somite formation and embryo turning, incomplete penetrance 0.0196521445533971 0.0876070064096332 0.867276887871854 0.75 5.5 5 5 decreased midbrain size 0.0196521445533971 0.0876070064096332 0.867276887871854 0.75 5.5 5 5 abnormal glossopharyngeal nerve morphology 0.043828566242333 0.156068156984988 0.867276887871854 0.75 5.5 5 5 absent optic nerve 0.043828566242333 0.156068156984988 0.867276887871854 0.75 5.5 5 5 altered tumor susceptibility 0.043828566242333 0.156068156984988 0.867276887871854 0.75 5.5 5 5 abnormal respiratory function 0.043828566242333 0.156068156984988 0.867276887871854 0.75 5.5 5 5 increased circulating parathyroid hormone level 0.043828566242333 0.156068156984988 0.867276887871854 0.75 5.5 5 5 loss of dopaminergic neurons 0.043828566242333 0.156068156984988 0.867276887871854 0.75 5.5 5 5 small intestinal inflammation 0.043828566242333 0.156068156984988 0.867276887871854 0.75 5.5 5 5 abnormal defecation 0.043828566242333 0.156068156984988 0.867276887871854 0.75 5.5 5 5 abnormal rostral-caudal body axis extension 0.043828566242333 0.156068156984988 0.867276887871854 0.75 5.5 5 5 vestibular saccular macula degeneration 0.043828566242333 0.156068156984988 0.867276887871854 0.75 5.5 5 5 bowed ulna 0.043828566242333 0.156068156984988 0.867276887871854 0.75 5.5 5 5 abnormal cochlear outer hair cell physiology 0.043828566242333 0.156068156984988 0.867276887871854 0.75 5.5 5 5 hematuria 0.043828566242333 0.156068156984988 0.867276887871854 0.75 5.5 5 5 abnormal somatic nervous system physiology 0.043828566242333 0.156068156984988 0.867276887871854 0.75 5.5 5 5 increased type II pneumocyte number 0.043828566242333 0.156068156984988 0.867276887871854 0.75 5.5 5 5 prenatal growth retardation 0.043828566242333 0.156068156984988 0.867276887871854 0.75 5.5 5 5 abnormal ear pigmentation 0.101987973235105 0.266486432166307 0.867276887871854 0.75 5.5 5 5 failure of vascular branching 0.101987973235105 0.266486432166307 0.867276887871854 0.75 5.5 5 5 schistocytosis 0.101987973235105 0.266486432166307 0.867276887871854 0.75 5.5 5 5 abnormal cecum morphology 0.101987973235105 0.266486432166307 0.867276887871854 0.75 5.5 5 5 clubfoot 0.101987973235105 0.266486432166307 0.867276887871854 0.75 5.5 5 5 absent mammary gland 0.101987973235105 0.266486432166307 0.867276887871854 0.75 5.5 5 5 enlarged pituitary gland 0.101987973235105 0.266486432166307 0.867276887871854 0.75 5.5 5 5 abnormal hypoglossal nerve morphology 0.101987973235105 0.266486432166307 0.867276887871854 0.75 5.5 5 5 absent skin pigmentation 0.101987973235105 0.266486432166307 0.867276887871854 0.75 5.5 5 5 increased sensitivity to skin irradiation 0.101987973235105 0.266486432166307 0.867276887871854 0.75 5.5 5 5 dermal cysts 0.101987973235105 0.266486432166307 0.867276887871854 0.75 5.5 5 5 abnormal pupil morphology 0.101987973235105 0.266486432166307 0.867276887871854 0.75 5.5 5 5 dry eyes 0.101987973235105 0.266486432166307 0.867276887871854 0.75 5.5 5 5 unidirectional circling 0.101987973235105 0.266486432166307 0.867276887871854 0.75 5.5 5 5 spinning 0.101987973235105 0.266486432166307 0.867276887871854 0.75 5.5 5 5 abnormal atrial thrombosis 0.101987973235105 0.266486432166307 0.867276887871854 0.75 5.5 5 5 preneoplasia 0.101987973235105 0.266486432166307 0.867276887871854 0.75 5.5 5 5 abnormal hepatobiliary system morphology 0.101987973235105 0.266486432166307 0.867276887871854 0.75 5.5 5 5 abnormal pulmonary circulation 0.101987973235105 0.266486432166307 0.867276887871854 0.75 5.5 5 5 abnormal thyroid physiology 0.101987973235105 0.266486432166307 0.867276887871854 0.75 5.5 5 5 short ureter 0.101987973235105 0.266486432166307 0.867276887871854 0.75 5.5 5 5 abnormal neuron apoptosis 0.101987973235105 0.266486432166307 0.867276887871854 0.75 5.5 5 5 decreased susceptibility to age related obesity 0.101987973235105 0.266486432166307 0.867276887871854 0.75 5.5 5 5 increased cardiac output 0.101987973235105 0.266486432166307 0.867276887871854 0.75 5.5 5 5 abnormal platelet shape 0.101987973235105 0.266486432166307 0.867276887871854 0.75 5.5 5 5 abnormal ovary development 0.101987973235105 0.266486432166307 0.867276887871854 0.75 5.5 5 5 bowed fibula 0.101987973235105 0.266486432166307 0.867276887871854 0.75 5.5 5 5 abnormal hair follicle melanocyte morphology 0.101987973235105 0.266486432166307 0.867276887871854 0.75 5.5 5 5 abnormal choroid pigmentation 0.101987973235105 0.266486432166307 0.867276887871854 0.75 5.5 5 5 non-pigmented tail tip 0.101987973235105 0.266486432166307 0.867276887871854 0.75 5.5 5 5 abnormal vertebral body development 0.101987973235105 0.266486432166307 0.867276887871854 0.75 5.5 5 5 ectrodactyly 0.101987973235105 0.266486432166307 0.867276887871854 0.75 5.5 5 5 ocular hypertension 0.101987973235105 0.266486432166307 0.867276887871854 0.75 5.5 5 5 increased pulmonary ventilation 0.101987973235105 0.266486432166307 0.867276887871854 0.75 5.5 5 5 abnormal sphingomyelin level 0.101987973235105 0.266486432166307 0.867276887871854 0.75 5.5 5 5 abnormal frontonasal prominence morphology 0.101987973235105 0.266486432166307 0.867276887871854 0.75 5.5 5 5 pulmonary artery hypoplasia 0.101987973235105 0.266486432166307 0.867276887871854 0.75 5.5 5 5 sinoatrial block 0.101987973235105 0.266486432166307 0.867276887871854 0.75 5.5 5 5 delayed suture closure 0.101987973235105 0.266486432166307 0.867276887871854 0.75 5.5 5 5 decreased alveolar lamellar body number 0.101987973235105 0.266486432166307 0.867276887871854 0.75 5.5 5 5 abnormal bronchiole epithelium morphology 0.101987973235105 0.266486432166307 0.867276887871854 0.75 5.5 5 5 abnormal bronchus epithelium morphology 0.101987973235105 0.266486432166307 0.867276887871854 0.75 5.5 5 5 absent ureteric bud 0.101987973235105 0.266486432166307 0.867276887871854 0.75 5.5 5 5 increased aorta wall thickness 0.101987973235105 0.266486432166307 0.867276887871854 0.75 5.5 5 5 lethality during fetal growth through weaning, incomplete penetrance 0.101987973235105 0.266486432166307 0.867276887871854 0.75 5.5 5 5 increased circulating ferritin level 0.101987973235105 0.266486432166307 0.867276887871854 0.75 5.5 5 5 increased cardiac stroke volume 0.101987973235105 0.266486432166307 0.867276887871854 0.75 5.5 5 5 increased cornea thickness 0.101987973235105 0.266486432166307 0.867276887871854 0.75 5.5 5 5 decreased basal metabolism 0.101987973235105 0.266486432166307 0.867276887871854 0.75 5.5 5 5 decreased vascular endothelial cell proliferation 0.101987973235105 0.266486432166307 0.867276887871854 0.75 5.5 5 5 abnormal retinal pigment epithelium morphology 1.73694620360152e-07 4.00060526060998e-06 0.867276887871853 0.75 5.5 5 5 abnormal circulating enzyme level 0.00903200437916215 0.048057991215328 0.867276887871853 0.75 5.5 5 5 increased mammary adenocarcinoma incidence 0.00903200437916215 0.048057991215328 0.867276887871853 0.75 5.5 5 5 abnormal hearing physiology 0.00903200437916215 0.048057991215328 0.867276887871853 0.75 5.5 5 5 abnormal trachea morphology 0.00903200437916215 0.048057991215328 0.867276887871853 0.75 5.5 5 5 dilated vasculature 0.00903200437916215 0.048057991215328 0.867276887871853 0.75 5.5 5 5 decreased body weight 5.84855484290078e-96 1.45482801717157e-92 0.865875794353482 0.748788368336026 5.5 5 5 abnormal rib morphology 1.53145284507408e-11 7.05460917059589e-10 0.865135463457355 0.748148148148148 5.5 5 5 cleft palate 3.0805968825292e-11 1.36839013308775e-09 0.865070076452332 0.748091603053435 5.5 5 5 abnormal vitelline vasculature morphology 5.05979183442907e-10 1.83740615885289e-08 0.864763041820051 0.747826086956522 5.5 5 5 abnormal spleen morphology 2.31859888123371e-14 1.67174339625184e-12 0.863953987918322 0.747126436781609 5.5 5 5 postnatal lethality 9.3490062987859e-14 5.96298799185383e-12 0.863793848161525 0.746987951807229 5.5 5 5 decreased body size 6.61644717152098e-61 5.48613744638614e-58 0.863654177396198 0.746867167919799 5.5 5 5 microphthalmia 1.22762219261233e-12 6.71145099807288e-11 0.861608411480534 0.745098039215686 5.5 5 5 abnormal gastrulation 4.11476335149634e-05 0.000531712926589462 0.861608411480534 0.745098039215686 5.5 5 5 cochlear inner hair cell degeneration 4.11476335149634e-05 0.000531712926589462 0.861608411480534 0.745098039215686 5.5 5 5 abnormal innervation 8.44790902474701e-05 0.00100067493805039 0.861125987957869 0.74468085106383 5.5 5 5 neuron degeneration 8.44790902474701e-05 0.00100067493805039 0.861125987957869 0.74468085106383 5.5 5 5 abnormal organ of Corti morphology 0.000173973000122984 0.00185732977599108 0.860553811221684 0.744186046511628 5.5 5 5 abnormal left-right axis patterning 0.000173973000122984 0.00185732977599108 0.860553811221684 0.744186046511628 5.5 5 5 decreased B-1 B cell number 0.000359583190806979 0.0033945471997433 0.85986426489859 0.743589743589744 5.5 5 5 abnormal intestine morphology 9.31622241980406e-07 1.83194492247135e-05 0.859463582575711 0.743243243243243 5.5 5 5 domed cranium 1.89142776136894e-06 3.39705888549114e-05 0.85901710798736 0.742857142857143 5.5 5 5 thick pulmonary interalveolar septum 0.000746512011842835 0.00617952954894859 0.85901710798736 0.742857142857143 5.5 5 5 increased carcinoma incidence 0.000746512011842835 0.00617952954894859 0.85901710798736 0.742857142857143 5.5 5 5 decreased triglyceride level 0.000746512011842835 0.00617952954894859 0.85901710798736 0.742857142857143 5.5 5 5 decreased bone volume 0.000746512011842835 0.00617952954894859 0.85901710798736 0.742857142857143 5.5 5 5 osteopetrosis 0.00155827143351792 0.0115037694447689 0.857951329937748 0.741935483870968 5.5 5 5 pale kidney 0.00155827143351792 0.0115037694447689 0.857951329937748 0.741935483870968 5.5 5 5 decreased double-negative T cell number 0.00155827143351792 0.0115037694447689 0.857951329937748 0.741935483870968 5.5 5 5 cochlear ganglion degeneration 1.59652634473158e-05 0.000230223726522888 0.857308188011258 0.741379310344828 5.5 5 5 reduced fertility 2.59476178484218e-11 1.16296755671981e-09 0.856877884420153 0.741007194244604 5.5 5 5 decreased platelet aggregation 3.26227061411802e-05 0.000432794568139657 0.856569765799362 0.740740740740741 5.5 5 5 decreased bone mineral content 3.89010190246777e-16 3.65155791788249e-14 0.856157953411958 0.740384615384615 5.5 5 5 respiratory distress 1.26869521572245e-13 7.98956797242936e-12 0.855579511734854 0.739884393063584 5.5 5 5 decreased hematocrit 1.03463690401062e-11 4.90220818805031e-10 0.85539638255854 0.73972602739726 5.5 5 5 abnormal seminiferous tubule morphology 1.03463690401062e-11 4.90220818805031e-10 0.85539638255854 0.73972602739726 5.5 5 5 perimembraneous ventricular septal defect 3.05597095072749e-06 5.17124336049975e-05 0.854707657612841 0.739130434782609 5.5 5 5 abnormal allantois morphology 0.000137180370404877 0.00149664987448303 0.854707657612841 0.739130434782609 5.5 5 5 abnormal innervation pattern to muscle 0.00694583293019273 0.0382251314465806 0.854707657612841 0.739130434782609 5.5 5 5 abnormal sacral vertebrae morphology 0.00694583293019273 0.0382251314465806 0.854707657612841 0.739130434782609 5.5 5 5 abnormal vertebral artery topology 0.00694583293019273 0.0382251314465806 0.854707657612841 0.739130434782609 5.5 5 5 abnormal cranium morphology 8.38218411487178e-11 3.41814475176124e-09 0.854332456709587 0.738805970149254 5.5 5 5 premature death 6.71437068834133e-62 6.68079883489962e-59 0.854182114884241 0.738675958188153 5.5 5 5 abnormal suckling behavior 1.44374492521411e-07 3.37725088607898e-06 0.854136328964704 0.738636363636364 5.5 5 5 skin edema 0.000282542766275286 0.00277248572429891 0.853510588064364 0.738095238095238 5.5 5 5 abnormal spleen white pulp morphology 0.000282542766275286 0.00277248572429891 0.853510588064364 0.738095238095238 5.5 5 5 abnormal maternal nurturing 1.26423801844278e-05 0.000187748780350831 0.853059233972315 0.737704918032787 5.5 5 5 abnormal facial morphology 2.57756860243868e-05 0.000350366223965367 0.852061503874102 0.736842105263158 5.5 5 5 abnormal frontal bone morphology 0.000584081041956422 0.00503605404459826 0.852061503874102 0.736842105263158 5.5 5 5 incomplete somite formation 0.000584081041956422 0.00503605404459826 0.852061503874102 0.736842105263158 5.5 5 5 thin dermal layer 0.014909382235253 0.0697938114521289 0.852061503874102 0.736842105263158 5.5 5 5 abnormal digestive system development 0.014909382235253 0.0697938114521289 0.852061503874102 0.736842105263158 5.5 5 5 abnormal sternebra morphology 0.014909382235253 0.0697938114521289 0.852061503874102 0.736842105263158 5.5 5 5 Leydig cell hypoplasia 0.014909382235253 0.0697938114521289 0.852061503874102 0.736842105263158 5.5 5 5 decreased birth weight 5.6894102383778e-08 1.4551516424252e-06 0.852061503874102 0.736842105263158 5.5 5 5 abnormal forebrain development 2.42210273368718e-06 4.22805652634868e-05 0.851216204763116 0.736111111111111 5.5 5 5 abnormal heart left ventricle morphology 2.42210273368718e-06 4.22805652634868e-05 0.851216204763116 0.736111111111111 5.5 5 5 cochlear outer hair cell degeneration 2.42210273368718e-06 4.22805652634868e-05 0.851216204763116 0.736111111111111 5.5 5 5 abnormal heart morphology 3.17697317844939e-17 3.29280032558035e-15 0.851007624463002 0.735930735930736 5.5 5 5 postnatal lethality, complete penetrance 9.06835892155856e-28 2.14833741117875e-25 0.850800124889832 0.735751295336788 5.5 5 5 abnormal bone mineralization 1.08958842491999e-09 3.73841545791515e-08 0.850552540171845 0.735537190082645 5.5 5 5 abnormal endoderm development 0.00121281817595085 0.00945732041591771 0.850271458697896 0.735294117647059 5.5 5 5 abnormal vision 0.00121281817595085 0.00945732041591771 0.850271458697896 0.735294117647059 5.5 5 5 abnormal long bone hypertrophic chondrocyte zone 0.000107791843188477 0.00122714970220291 0.849577359547938 0.73469387755102 5.5 5 5 neonatal lethality, complete penetrance 2.67367755359476e-32 8.3134661432087e-30 0.849525606541143 0.734649122807018 5.5 5 5 abnormal placenta labyrinth morphology 9.46477825851896e-07 1.84655967984831e-05 0.848979907115064 0.734177215189873 5.5 5 5 abnormal visceral yolk sac morphology 9.46477825851896e-07 1.84655967984831e-05 0.848979907115064 0.734177215189873 5.5 5 5 abnormal limb morphology 1.91512661666309e-06 3.42724997046721e-05 0.848004068141368 0.733333333333333 5.5 5 5 abnormal kidney development 2.03078916356483e-05 0.000283002131337116 0.848004068141368 0.733333333333333 5.5 5 5 muscular ventricular septal defect 2.03078916356483e-05 0.000283002131337116 0.848004068141368 0.733333333333333 5.5 5 5 cardiomyopathy 0.000221240106904114 0.00225447450343477 0.848004068141368 0.733333333333333 5.5 5 5 abnormal heart tube morphology 0.00253222943262783 0.0171234142818948 0.848004068141368 0.733333333333333 5.5 5 5 abnormal pain threshold 0.00253222943262783 0.0171234142818948 0.848004068141368 0.733333333333333 5.5 5 5 abnormal cellular respiration 0.00253222943262783 0.0171234142818948 0.848004068141368 0.733333333333333 5.5 5 5 macrocytosis 0.03255911743706 0.127713476575588 0.848004068141368 0.733333333333333 5.5 5 5 decreased hepatocyte number 0.03255911743706 0.127713476575588 0.848004068141368 0.733333333333333 5.5 5 5 absent egg cylinders 0.03255911743706 0.127713476575588 0.848004068141368 0.733333333333333 5.5 5 5 delayed intramembranous bone ossification 0.03255911743706 0.127713476575588 0.848004068141368 0.733333333333333 5.5 5 5 increased alcohol consumption 0.03255911743706 0.127713476575588 0.848004068141368 0.733333333333333 5.5 5 5 dilated ureter 0.03255911743706 0.127713476575588 0.848004068141368 0.733333333333333 5.5 5 5 abnormal ear development 0.03255911743706 0.127713476575588 0.848004068141368 0.733333333333333 5.5 5 5 abnormal energy homeostasis 0.03255911743706 0.127713476575588 0.848004068141368 0.733333333333333 5.5 5 5 abnormal dendritic cell morphology 0.03255911743706 0.127713476575588 0.848004068141368 0.733333333333333 5.5 5 5 abnormal Muller cell morphology 0.03255911743706 0.127713476575588 0.848004068141368 0.733333333333333 5.5 5 5 abnormal secondary palate development 0.03255911743706 0.127713476575588 0.848004068141368 0.733333333333333 5.5 5 5 abnormal aorta wall morphology 0.03255911743706 0.127713476575588 0.848004068141368 0.733333333333333 5.5 5 5 bicuspid aortic valve 0.03255911743706 0.127713476575588 0.848004068141368 0.733333333333333 5.5 5 5 abnormal microglial cell activation 0.03255911743706 0.127713476575588 0.848004068141368 0.733333333333333 5.5 5 5 postnatal growth retardation 4.09915732515281e-42 2.03933076926352e-39 0.846492474437016 0.73202614379085 5.5 5 5 sparse hair 7.47999597325312e-07 1.51272276288351e-05 0.846123793045711 0.731707317073171 5.5 5 5 increased bone trabecula number 0.00045545884205565 0.00403718933860632 0.846123793045711 0.731707317073171 5.5 5 5 internal hemorrhage 7.86381204810881e-06 0.000125392515831222 0.845702835934743 0.73134328358209 5.5 5 5 reduced male fertility 2.04898313486613e-16 1.99876295999196e-14 0.845626804033643 0.731277533039648 5.5 5 5 abnormal definitive hematopoiesis 1.45272701431337e-07 3.37725088607898e-06 0.845517252692273 0.731182795698925 5.5 5 5 lethargy 1.45272701431337e-07 3.37725088607898e-06 0.845517252692273 0.731182795698925 5.5 5 5 abnormal blood vessel morphology 5.37532979859058e-11 2.26629370745662e-09 0.845345748178542 0.731034482758621 5.5 5 5 abnormal cornea morphology 1.51110918603953e-06 2.7740842068438e-05 0.845039018952062 0.730769230769231 5.5 5 5 thick skin 0.0053237615344995 0.0314530113594049 0.845039018952062 0.730769230769231 5.5 5 5 heart inflammation 0.0053237615344995 0.0314530113594049 0.845039018952062 0.730769230769231 5.5 5 5 decreased susceptibility to hepatic steatosis 1.59618134859047e-05 0.000230223726522888 0.844333054859371 0.73015873015873 5.5 5 5 abnormal liver physiology 5.70360945272188e-08 1.4551516424252e-06 0.844149504195271 0.73 5.5 5 5 abnormal angiogenesis 3.05508333925104e-06 5.17124336049975e-05 0.843836971983425 0.72972972972973 5.5 5 5 decreased width of hypertrophic chondrocyte zone 0.000940999484211497 0.00753860295322415 0.843836971983425 0.72972972972973 5.5 5 5 abnormal chromosome morphology 0.000940999484211497 0.00753860295322415 0.843836971983425 0.72972972972973 5.5 5 5 abnormal enterocyte morphology 0.011293765771447 0.0549334995856956 0.840995770057555 0.727272727272727 5.5 5 5 abnormal chorion morphology 0.011293765771447 0.0549334995856956 0.840995770057555 0.727272727272727 5.5 5 5 aphakia 0.011293765771447 0.0549334995856956 0.840995770057555 0.727272727272727 5.5 5 5 abnormal cochlear sensory epithelium morphology 0.011293765771447 0.0549334995856956 0.840995770057555 0.727272727272727 5.5 5 5 abnormal female reproductive system physiology 0.011293765771447 0.0549334995856956 0.840995770057555 0.727272727272727 5.5 5 5 increased circulating creatine kinase level 0.011293765771447 0.0549334995856956 0.840995770057555 0.727272727272727 5.5 5 5 absent semicircular canals 0.0730109843825385 0.226452398568036 0.840995770057555 0.727272727272727 5.5 5 5 abnormal sphenoid bone morphology 0.0730109843825385 0.226452398568036 0.840995770057555 0.727272727272727 5.5 5 5 abnormal large intestine morphology 0.0730109843825385 0.226452398568036 0.840995770057555 0.727272727272727 5.5 5 5 abnormal eye distance/ position 0.0730109843825385 0.226452398568036 0.840995770057555 0.727272727272727 5.5 5 5 impaired myelopoiesis 0.0730109843825385 0.226452398568036 0.840995770057555 0.727272727272727 5.5 5 5 abnormal proximal-distal axis patterning 0.0730109843825385 0.226452398568036 0.840995770057555 0.727272727272727 5.5 5 5 abnormal larynx morphology 0.0730109843825385 0.226452398568036 0.840995770057555 0.727272727272727 5.5 5 5 abnormal bronchiole morphology 0.0730109843825385 0.226452398568036 0.840995770057555 0.727272727272727 5.5 5 5 fused joints 0.0730109843825385 0.226452398568036 0.840995770057555 0.727272727272727 5.5 5 5 loss of cortex neurons 0.0730109843825385 0.226452398568036 0.840995770057555 0.727272727272727 5.5 5 5 impaired luteinization 0.0730109843825385 0.226452398568036 0.840995770057555 0.727272727272727 5.5 5 5 dilated renal glomerular capsule 0.0730109843825385 0.226452398568036 0.840995770057555 0.727272727272727 5.5 5 5 abnormal pituitary gland development 0.0730109843825385 0.226452398568036 0.840995770057555 0.727272727272727 5.5 5 5 abnormal coronal suture morphology 0.0730109843825385 0.226452398568036 0.840995770057555 0.727272727272727 5.5 5 5 pharyngeal arch hypoplasia 0.0730109843825385 0.226452398568036 0.840995770057555 0.727272727272727 5.5 5 5 cyclopia 0.0730109843825385 0.226452398568036 0.840995770057555 0.727272727272727 5.5 5 5 abnormal Bruch membrane morphology 0.0730109843825385 0.226452398568036 0.840995770057555 0.727272727272727 5.5 5 5 increased glycogen level 0.0730109843825385 0.226452398568036 0.840995770057555 0.727272727272727 5.5 5 5 enhanced behavioral response to addictive substance 0.0730109843825385 0.226452398568036 0.840995770057555 0.727272727272727 5.5 5 5 palatal shelf hypoplasia 0.0730109843825385 0.226452398568036 0.840995770057555 0.727272727272727 5.5 5 5 aorta dilation 0.0730109843825385 0.226452398568036 0.840995770057555 0.727272727272727 5.5 5 5 common atrioventricular valve 0.0730109843825385 0.226452398568036 0.840995770057555 0.727272727272727 5.5 5 5 increased pancreatic beta cell proliferation 0.0730109843825385 0.226452398568036 0.840995770057555 0.727272727272727 5.5 5 5 abnormal phrenic nerve innervation pattern to diaphragm 0.0730109843825385 0.226452398568036 0.840995770057555 0.727272727272727 5.5 5 5 cataract 3.47435973901423e-09 1.09398352541746e-07 0.840995770057555 0.727272727272727 5.5 5 5 abnormal joint morphology 6.60324237492731e-05 0.000799297586746068 0.840995770057555 0.727272727272727 5.5 5 5 myeloid hyperplasia 0.00195256468492439 0.0138970090236035 0.840995770057555 0.727272727272727 5.5 5 5 kyphosis 5.33574076824395e-11 2.26629370745662e-09 0.840294940249174 0.726666666666667 5.5 5 5 extramedullary hematopoiesis 3.55035953759519e-08 9.49625736534197e-07 0.840004029762676 0.726415094339623 5.5 5 5 decreased percent body fat/body weight 4.85101876434066e-06 7.96495655201147e-05 0.839555708807456 0.726027397260274 5.5 5 5 increased tumor incidence 2.74124605752877e-09 8.79851557174556e-08 0.839300214069536 0.725806451612903 5.5 5 5 kinked tail 7.12419389482315e-08 1.77214323133726e-06 0.838934505915257 0.725490196078431 5.5 5 5 failure of chorioallantoic fusion 0.00013463005869704 0.0014720539385006 0.838934505915257 0.725490196078431 5.5 5 5 small spleen 3.65442221935279e-07 7.87234616474808e-06 0.838685342117836 0.725274725274725 5.5 5 5 abnormal vertebrae morphology 2.79575855070863e-08 7.7271659943197e-07 0.838102435986256 0.724770642201835 5.5 5 5 thymus hypoplasia 4.26001942478117e-10 1.58161168942435e-08 0.837948683934158 0.72463768115942 5.5 5 5 abnormal spermiogenesis 5.15280452891975e-05 0.000650974276446012 0.837370788290066 0.724137931034483 5.5 5 5 focal hair loss 0.00407308045692137 0.025297846783001 0.837370788290066 0.724137931034483 5.5 5 5 decreased trophoblast giant cell number 0.00407308045692137 0.025297846783001 0.837370788290066 0.724137931034483 5.5 5 5 cyanosis 2.04529097153214e-13 1.21134792659195e-11 0.83716310704297 0.723958333333333 5.5 5 5 increased circulating HDL cholesterol level 5.60336375747168e-08 1.44439039862288e-06 0.836991028295376 0.723809523809524 5.5 5 5 abnormal axial skeleton morphology 3.80083768395926e-06 6.36672305646374e-05 0.83684611987635 0.723684210526316 5.5 5 5 abnormal cell nucleus morphology 0.000275014487739636 0.00272549218427229 0.83652238830193 0.723404255319149 5.5 5 5 increased respiratory quotient 0.000275014487739636 0.00272549218427229 0.83652238830193 0.723404255319149 5.5 5 5 short tail 1.47803478915366e-06 2.73354017696635e-05 0.835929530478895 0.72289156626506 5.5 5 5 abnormal lung morphology 8.64072145167429e-09 2.51389410655436e-07 0.835695376548789 0.722689075630252 5.5 5 5 abnormal cochlea morphology 0.000104730469818369 0.00120053937176586 0.835155521654378 0.722222222222222 5.5 5 5 abnormal chondrocyte morphology 0.000104730469818369 0.00120053937176586 0.835155521654378 0.722222222222222 5.5 5 5 increased cell proliferation 0.000104730469818369 0.00120053937176586 0.835155521654378 0.722222222222222 5.5 5 5 polyphagia 0.000104730469818369 0.00120053937176586 0.835155521654378 0.722222222222222 5.5 5 5 renal hypoplasia 0.00150295062669593 0.0112602817775539 0.835155521654377 0.722222222222222 5.5 5 5 abnormal retinal blood vessel morphology 0.00150295062669593 0.0112602817775539 0.835155521654377 0.722222222222222 5.5 5 5 blepharoptosis 0.0242504577253593 0.098890186216117 0.835155521654377 0.722222222222222 5.5 5 5 abnormal thyroid cartilage morphology 0.0242504577253593 0.098890186216117 0.835155521654377 0.722222222222222 5.5 5 5 abnormal Peyer's patch follicle morphology 0.0242504577253593 0.098890186216117 0.835155521654377 0.722222222222222 5.5 5 5 jerky movement 0.0242504577253593 0.098890186216117 0.835155521654377 0.722222222222222 5.5 5 5 decreased pulmonary respiratory rate 0.0242504577253593 0.098890186216117 0.835155521654377 0.722222222222222 5.5 5 5 small thoracic cage 0.0242504577253593 0.098890186216117 0.835155521654377 0.722222222222222 5.5 5 5 atrioventricular block 0.0242504577253593 0.098890186216117 0.835155521654377 0.722222222222222 5.5 5 5 increased effector memory CD8-positive, alpha-beta T cell number 0.0242504577253593 0.098890186216117 0.835155521654377 0.722222222222222 5.5 5 5 abnormal myocardial fiber morphology 2.25148268030882e-07 5.11466955914903e-06 0.834493225443708 0.721649484536082 5.5 5 5 hunched posture 2.97401771016204e-06 5.06703359864937e-05 0.834342322509631 0.721518987341772 5.5 5 5 kidney failure 0.000563014662168729 0.00489684955295355 0.833661504621006 0.720930232558139 5.5 5 5 delayed bone ossification 5.98640062590583e-06 9.6695919200914e-05 0.832585812356979 0.72 5.5 5 5 abnormal neurocranium morphology 5.98640062590583e-06 9.6695919200914e-05 0.832585812356979 0.72 5.5 5 5 abnormal interventricular septum morphology 0.000213175073817055 0.00219121072776828 0.832585812356979 0.72 5.5 5 5 abnormal hindlimb morphology 0.000213175073817055 0.00219121072776828 0.832585812356979 0.72 5.5 5 5 increased circulating chloride level 0.000213175073817055 0.00219121072776828 0.832585812356979 0.72 5.5 5 5 abnormal primitive streak morphology 0.00855309626902975 0.0459521100846901 0.832585812356979 0.72 5.5 5 5 abnormal preimplantation embryo development 0.00855309626902975 0.0459521100846901 0.832585812356979 0.72 5.5 5 5 increased or absent threshold for auditory brainstem response 7.4283050976065e-19 8.59437624664938e-17 0.832265710160764 0.719723183391003 5.5 5 5 abnormal craniofacial bone morphology 8.1358832491875e-05 0.000970647941599707 0.831774325210433 0.719298245614035 5.5 5 5 increased hepatocellular carcinoma incidence 8.1358832491875e-05 0.000970647941599707 0.831774325210433 0.719298245614035 5.5 5 5 increased body weight 7.63405134666043e-15 6.22613204092387e-13 0.831140350877193 0.71875 5.5 5 5 decreased caudal vertebrae number 3.12414615567591e-05 0.000416692416206104 0.831140350877193 0.71875 5.5 5 5 scoliosis 0.00311325422297138 0.0200887675217673 0.831140350877193 0.71875 5.5 5 5 kidney cortex cysts 0.00311325422297138 0.0200887675217673 0.831140350877193 0.71875 5.5 5 5 increased circulating follicle stimulating hormone level 0.00311325422297138 0.0200887675217673 0.831140350877193 0.71875 5.5 5 5 abnormal heart atrium morphology 0.00311325422297138 0.0200887675217673 0.831140350877193 0.71875 5.5 5 5 intracranial hemorrhage 6.31319561188255e-05 0.000773599708598909 0.828731248410882 0.716666666666667 5.5 5 5 increased total body fat amount 2.56790698860888e-09 8.29567355086309e-08 0.828443594385054 0.716417910447761 5.5 5 5 decreased hemoglobin content 1.0109022132251e-09 3.49252674360757e-08 0.828321188416617 0.716312056737589 5.5 5 5 anemia 9.3043476996225e-14 5.96298799185383e-12 0.827543823498577 0.71563981042654 5.5 5 5 abnormal liver morphology 7.56353417793216e-12 3.76285825352125e-10 0.826900868883406 0.715083798882682 5.5 5 5 polydactyly 4.30568260929345e-07 9.07659787340462e-06 0.825977988449384 0.714285714285714 5.5 5 5 increased circulating LDL cholesterol level 0.000335214722563076 0.00321328178179442 0.825977988449384 0.714285714285714 5.5 5 5 increased T cell derived lymphoma incidence 0.000335214722563076 0.00321328178179442 0.825977988449384 0.714285714285714 5.5 5 5 decreased circulating creatinine level 0.000335214722563076 0.00321328178179442 0.825977988449384 0.714285714285714 5.5 5 5 abnormal kidney morphology 1.50003086264575e-11 6.97444256230148e-10 0.825977988449384 0.714285714285714 5.5 5 5 abnormal artery morphology 0.00237858358622091 0.0162324462845666 0.825977988449384 0.714285714285714 5.5 5 5 increased circulating serum albumin level 0.00237858358622091 0.0162324462845666 0.825977988449384 0.714285714285714 5.5 5 5 abnormal midbrain development 0.00237858358622091 0.0162324462845666 0.825977988449384 0.714285714285714 5.5 5 5 decreased glycogen level 0.00237858358622091 0.0162324462845666 0.825977988449384 0.714285714285714 5.5 5 5 increased red blood cell distribution width 0.00237858358622091 0.0162324462845666 0.825977988449384 0.714285714285714 5.5 5 5 enhanced coordination 0.00648013602358033 0.0362232322666429 0.825977988449384 0.714285714285714 5.5 5 5 abnormal hormone level 0.00648013602358033 0.0362232322666429 0.825977988449384 0.714285714285714 5.5 5 5 small ears 0.0181145733132148 0.0827919738972549 0.825977988449384 0.714285714285714 5.5 5 5 abnormal salivary gland morphology 0.0181145733132148 0.0827919738972549 0.825977988449384 0.714285714285714 5.5 5 5 abnormal hematopoietic system physiology 0.0181145733132148 0.0827919738972549 0.825977988449384 0.714285714285714 5.5 5 5 abnormal associative learning 0.0181145733132148 0.0827919738972549 0.825977988449384 0.714285714285714 5.5 5 5 decreased cochlear outer hair cell number 0.0181145733132148 0.0827919738972549 0.825977988449384 0.714285714285714 5.5 5 5 abnormal blood flow velocity 0.0529733479362896 0.175577885398428 0.825977988449384 0.714285714285714 5.5 5 5 megacephaly 0.0529733479362896 0.175577885398428 0.825977988449384 0.714285714285714 5.5 5 5 irregularly shaped pupil 0.0529733479362896 0.175577885398428 0.825977988449384 0.714285714285714 5.5 5 5 increased aggression towards males 0.0529733479362896 0.175577885398428 0.825977988449384 0.714285714285714 5.5 5 5 abnormal pinna reflex 0.0529733479362896 0.175577885398428 0.825977988449384 0.714285714285714 5.5 5 5 abnormal antigen presentation 0.0529733479362896 0.175577885398428 0.825977988449384 0.714285714285714 5.5 5 5 abnormal endplate potential 0.0529733479362896 0.175577885398428 0.825977988449384 0.714285714285714 5.5 5 5 abnormal vascular endothelial cell migration 0.0529733479362896 0.175577885398428 0.825977988449384 0.714285714285714 5.5 5 5 abnormal imprinting 0.0529733479362896 0.175577885398428 0.825977988449384 0.714285714285714 5.5 5 5 vascular smooth muscle hypoplasia 0.0529733479362896 0.175577885398428 0.825977988449384 0.714285714285714 5.5 5 5 abnormal sagittal suture morphology 0.0529733479362896 0.175577885398428 0.825977988449384 0.714285714285714 5.5 5 5 skeletal muscle necrosis 0.0529733479362896 0.175577885398428 0.825977988449384 0.714285714285714 5.5 5 5 split sternum 0.0529733479362896 0.175577885398428 0.825977988449384 0.714285714285714 5.5 5 5 increased circulating growth hormone level 0.0529733479362896 0.175577885398428 0.825977988449384 0.714285714285714 5.5 5 5 abnormal glucose tolerance 0.0529733479362896 0.175577885398428 0.825977988449384 0.714285714285714 5.5 5 5 decreased tongue size 0.0529733479362896 0.175577885398428 0.825977988449384 0.714285714285714 5.5 5 5 decreased compact bone area 0.0529733479362896 0.175577885398428 0.825977988449384 0.714285714285714 5.5 5 5 decreased response to antigen 0.0529733479362896 0.175577885398428 0.825977988449384 0.714285714285714 5.5 5 5 cochlear degeneration 0.171447955005602 0.395068817115734 0.825977988449384 0.714285714285714 5.5 5 5 cellular necrosis 0.171447955005602 0.395068817115734 0.825977988449384 0.714285714285714 5.5 5 5 broad head 0.171447955005602 0.395068817115734 0.825977988449384 0.714285714285714 5.5 5 5 maxilla hypoplasia 0.171447955005602 0.395068817115734 0.825977988449384 0.714285714285714 5.5 5 5 mammary gland hyperplasia 0.171447955005602 0.395068817115734 0.825977988449384 0.714285714285714 5.5 5 5 decreased Schwann cell number 0.171447955005602 0.395068817115734 0.825977988449384 0.714285714285714 5.5 5 5 absent epidermis stratum corneum 0.171447955005602 0.395068817115734 0.825977988449384 0.714285714285714 5.5 5 5 increased chemically-elicited antinociception 0.171447955005602 0.395068817115734 0.825977988449384 0.714285714285714 5.5 5 5 abnormal inhibitory postsynaptic potential 0.171447955005602 0.395068817115734 0.825977988449384 0.714285714285714 5.5 5 5 abnormal sinus venosus morphology 0.171447955005602 0.395068817115734 0.825977988449384 0.714285714285714 5.5 5 5 increased muscle weight 0.171447955005602 0.395068817115734 0.825977988449384 0.714285714285714 5.5 5 5 abnormal neurotransmitter uptake 0.171447955005602 0.395068817115734 0.825977988449384 0.714285714285714 5.5 5 5 abnormal response to novel odor 0.171447955005602 0.395068817115734 0.825977988449384 0.714285714285714 5.5 5 5 abnormal prostate gland physiology 0.171447955005602 0.395068817115734 0.825977988449384 0.714285714285714 5.5 5 5 anuria 0.171447955005602 0.395068817115734 0.825977988449384 0.714285714285714 5.5 5 5 increased cell nucleus count 0.171447955005602 0.395068817115734 0.825977988449384 0.714285714285714 5.5 5 5 abnormal central pattern generator function 0.171447955005602 0.395068817115734 0.825977988449384 0.714285714285714 5.5 5 5 increased ectoderm apoptosis 0.171447955005602 0.395068817115734 0.825977988449384 0.714285714285714 5.5 5 5 renal necrosis 0.171447955005602 0.395068817115734 0.825977988449384 0.714285714285714 5.5 5 5 abnormal organ of Corti supporting cell morphology 0.171447955005602 0.395068817115734 0.825977988449384 0.714285714285714 5.5 5 5 abnormal vestibular saccular macula morphology 0.171447955005602 0.395068817115734 0.825977988449384 0.714285714285714 5.5 5 5 abnormal cochlear hair cell physiology 0.171447955005602 0.395068817115734 0.825977988449384 0.714285714285714 5.5 5 5 abnormal negative T cell selection 0.171447955005602 0.395068817115734 0.825977988449384 0.714285714285714 5.5 5 5 increased prostate gland weight 0.171447955005602 0.395068817115734 0.825977988449384 0.714285714285714 5.5 5 5 abnormal gallbladder morphology 0.171447955005602 0.395068817115734 0.825977988449384 0.714285714285714 5.5 5 5 abnormal ciliary body morphology 0.171447955005602 0.395068817115734 0.825977988449384 0.714285714285714 5.5 5 5 decreased adrenocorticotropin level 0.171447955005602 0.395068817115734 0.825977988449384 0.714285714285714 5.5 5 5 atherosclerotic lesions 0.171447955005602 0.395068817115734 0.825977988449384 0.714285714285714 5.5 5 5 abnormal thyroid hormone level 0.171447955005602 0.395068817115734 0.825977988449384 0.714285714285714 5.5 5 5 abnormal renal/urinary system physiology 0.171447955005602 0.395068817115734 0.825977988449384 0.714285714285714 5.5 5 5 absent popliteal lymph nodes 0.171447955005602 0.395068817115734 0.825977988449384 0.714285714285714 5.5 5 5 abnormal uterus physiology 0.171447955005602 0.395068817115734 0.825977988449384 0.714285714285714 5.5 5 5 abnormal spinal cord central canal morphology 0.171447955005602 0.395068817115734 0.825977988449384 0.714285714285714 5.5 5 5 decreased behavioral withdrawal response 0.171447955005602 0.395068817115734 0.825977988449384 0.714285714285714 5.5 5 5 abnormal prostaglandin level 0.171447955005602 0.395068817115734 0.825977988449384 0.714285714285714 5.5 5 5 abnormal sperm annulus morphology 0.171447955005602 0.395068817115734 0.825977988449384 0.714285714285714 5.5 5 5 decreased DN4 thymocyte number 0.171447955005602 0.395068817115734 0.825977988449384 0.714285714285714 5.5 5 5 coronary fistula 0.171447955005602 0.395068817115734 0.825977988449384 0.714285714285714 5.5 5 5 long stride length 0.171447955005602 0.395068817115734 0.825977988449384 0.714285714285714 5.5 5 5 heart block 0.171447955005602 0.395068817115734 0.825977988449384 0.714285714285714 5.5 5 5 thick mitral valve cusps 0.171447955005602 0.395068817115734 0.825977988449384 0.714285714285714 5.5 5 5 abnormal impulsive behavior control 0.171447955005602 0.395068817115734 0.825977988449384 0.714285714285714 5.5 5 5 increased compact bone volume 0.171447955005602 0.395068817115734 0.825977988449384 0.714285714285714 5.5 5 5 small lung lobe 0.171447955005602 0.395068817115734 0.825977988449384 0.714285714285714 5.5 5 5 impaired mammary gland growth during pregnancy 0.171447955005602 0.395068817115734 0.825977988449384 0.714285714285714 5.5 5 5 absent heart tube 0.171447955005602 0.395068817115734 0.825977988449384 0.714285714285714 5.5 5 5 decreased areal bone mineral density 0.171447955005602 0.395068817115734 0.825977988449384 0.714285714285714 5.5 5 5 absent connection between subcutaneous lymph vessels and lymph sac 0.171447955005602 0.395068817115734 0.825977988449384 0.714285714285714 5.5 5 5 decreased collagen level 0.171447955005602 0.395068817115734 0.825977988449384 0.714285714285714 5.5 5 5 increased abdominal adipose tissue amount 0.171447955005602 0.395068817115734 0.825977988449384 0.714285714285714 5.5 5 5 increased thermal nociceptive threshold 1.10325016236432e-06 2.11102675298558e-05 0.825977988449384 0.714285714285714 5.5 5 5 decreased circulating glucose level 2.10082095733011e-17 2.22374133249304e-15 0.824793790616482 0.71326164874552 5.5 5 5 cleft secondary palate 8.59252811208519e-07 1.7031006915388e-05 0.82422058847396 0.712765957446808 5.5 5 5 decreased bone marrow cell number 1.46362870283092e-05 0.000214163317546583 0.823715035056372 0.712328767123288 5.5 5 5 increased heart weight 2.43951160330075e-09 7.98458567527712e-08 0.82360107337471 0.712230215827338 5.5 5 5 impaired swimming 3.79152091083732e-05 0.000495087048068653 0.823475024848023 0.712121212121212 5.5 5 5 abnormal tail morphology 3.79152091083732e-05 0.000495087048068653 0.823475024848023 0.712121212121212 5.5 5 5 abnormal hepatocyte morphology 1.02386175041206e-07 2.49691774916666e-06 0.823001491193711 0.711711711711712 5.5 5 5 decreased cardiac muscle contractility 2.61448778131777e-07 5.78092298313597e-06 0.822801150032271 0.711538461538462 5.5 5 5 abnormal snout morphology 0.000258376543947853 0.00257084661228114 0.822801150032271 0.711538461538462 5.5 5 5 abnormal reproductive system physiology 0.00181707202429213 0.0131585637858127 0.821630735878598 0.710526315789474 5.5 5 5 abnormal retinal outer nuclear layer morphology 0.00181707202429213 0.0131585637858127 0.821630735878598 0.710526315789474 5.5 5 5 hyporesponsive to tactile stimuli 0.00181707202429213 0.0131585637858127 0.821630735878598 0.710526315789474 5.5 5 5 decreased circulating cholesterol level 1.11046610477299e-11 5.2118574257034e-10 0.821464447528896 0.710382513661202 5.5 5 5 increased blood urea nitrogen level 1.48632939224641e-09 4.96274411169522e-08 0.821420868513112 0.710344827586207 5.5 5 5 small testis 7.77247566727744e-17 7.73361328894105e-15 0.821189710255475 0.710144927536232 5.5 5 5 hypoglycemia 1.33219051724599e-06 2.50099917860331e-05 0.820649098201324 0.709677419354839 5.5 5 5 increased lung adenoma incidence 0.00491301565267424 0.029097920085779 0.820649098201324 0.709677419354839 5.5 5 5 abnormal retinal photoreceptor layer morphology 0.00491301565267424 0.029097920085779 0.820649098201324 0.709677419354839 5.5 5 5 decreased thymus weight 0.00491301565267424 0.029097920085779 0.820649098201324 0.709677419354839 5.5 5 5 decreased neuronal precursor cell number 0.00491301565267424 0.029097920085779 0.820649098201324 0.709677419354839 5.5 5 5 abnormal podocyte morphology 0.00491301565267424 0.029097920085779 0.820649098201324 0.709677419354839 5.5 5 5 small cranium 0.00491301565267424 0.029097920085779 0.820649098201324 0.709677419354839 5.5 5 5 abnormal rostral-caudal axis patterning 0.000199056957111786 0.00208047975132592 0.819970875806116 0.709090909090909 5.5 5 5 abnormal myocardium layer morphology 8.798215272709e-06 0.000138955939624531 0.819704737904199 0.708860759493671 5.5 5 5 decreased B cell number 8.26142357310816e-13 4.6180429523835e-11 0.819562625432302 0.70873786407767 5.5 5 5 abnormal adrenal gland morphology 0.0135686404675283 0.0645353597762459 0.819094838545639 0.708333333333333 5.5 5 5 decreased metastatic potential 0.0135686404675283 0.0645353597762459 0.819094838545639 0.708333333333333 5.5 5 5 abnormal retinal ganglion layer morphology 0.0135686404675283 0.0645353597762459 0.819094838545639 0.708333333333333 5.5 5 5 increased body temperature 0.0135686404675283 0.0645353597762459 0.819094838545639 0.708333333333333 5.5 5 5 abnormal lung saccule morphology 0.0135686404675283 0.0645353597762459 0.819094838545639 0.708333333333333 5.5 5 5 abnormal mammary gland development 0.00138822891714739 0.0106580846648275 0.817919666610854 0.707317073170732 5.5 5 5 short humerus 0.00138822891714739 0.0106580846648275 0.817919666610854 0.707317073170732 5.5 5 5 spleen hyperplasia 1.7567822450075e-05 0.000251872958758279 0.817167556572591 0.706666666666667 5.5 5 5 increased insulin sensitivity 3.52819994849556e-09 1.1039493549538e-07 0.81673627669051 0.706293706293706 5.5 5 5 decreased mean corpuscular hemoglobin 4.54386558033089e-05 0.000582621939746035 0.81626060034998 0.705882352941177 5.5 5 5 thin skin 0.00372795630646091 0.0234174023038422 0.81626060034998 0.705882352941177 5.5 5 5 abnormal brown adipose tissue morphology 0.00372795630646091 0.0234174023038422 0.81626060034998 0.705882352941177 5.5 5 5 increased susceptibility to weight gain 0.00372795630646091 0.0234174023038422 0.81626060034998 0.705882352941177 5.5 5 5 abnormal adipose tissue morphology 0.0388014210147928 0.14590859376311 0.81626060034998 0.705882352941177 5.5 5 5 abnormal urinary bladder morphology 0.0388014210147928 0.14590859376311 0.81626060034998 0.705882352941177 5.5 5 5 distended urinary bladder 0.0388014210147928 0.14590859376311 0.81626060034998 0.705882352941177 5.5 5 5 increased aggression towards mice 0.0388014210147928 0.14590859376311 0.81626060034998 0.705882352941177 5.5 5 5 decreased vasoconstriction 0.0388014210147928 0.14590859376311 0.81626060034998 0.705882352941177 5.5 5 5 abnormal duodenum morphology 0.0388014210147928 0.14590859376311 0.81626060034998 0.705882352941177 5.5 5 5 abnormal electroretinogram waveform feature 0.0388014210147928 0.14590859376311 0.81626060034998 0.705882352941177 5.5 5 5 decreased body fat mass 0.0388014210147928 0.14590859376311 0.81626060034998 0.705882352941177 5.5 5 5 impaired hematopoiesis 0.000401683110105093 0.00368703592762516 0.81626060034998 0.705882352941177 5.5 5 5 impaired glucose tolerance 8.99467899514588e-15 7.10294095251599e-13 0.815986319234271 0.705645161290323 5.5 5 5 increased rib number 1.35830297181066e-05 0.00020052098767828 0.815388527059008 0.705128205128205 5.5 5 5 abnormal heart ventricle morphology 1.35830297181066e-05 0.00020052098767828 0.815388527059008 0.705128205128205 5.5 5 5 increased osteoclast cell number 0.000118037980535471 0.00132559583106991 0.815145490240212 0.704918032786885 5.5 5 5 increased circulating cholesterol level 7.96827750075839e-11 3.27621326993992e-09 0.814714652243256 0.704545454545455 5.5 5 5 abnormal myelopoiesis 0.00106081147566697 0.00831108203376882 0.814714652243256 0.704545454545455 5.5 5 5 omphalocele 0.00106081147566697 0.00831108203376882 0.814714652243256 0.704545454545455 5.5 5 5 renal interstitial fibrosis 0.00106081147566697 0.00831108203376882 0.814714652243256 0.704545454545455 5.5 5 5 abnormal skeleton morphology 1.47175651544952e-07 3.40557612295877e-06 0.814486120784002 0.704347826086957 5.5 5 5 corneal opacity 3.50637780830729e-05 0.000462711660380073 0.814344495654323 0.704225352112676 5.5 5 5 cardiac hypertrophy 1.23558948951934e-06 2.32843095089346e-05 0.814178302900107 0.704081632653061 5.5 5 5 short snout 3.7505809448603e-07 8.04273284512069e-06 0.813741277509394 0.703703703703704 5.5 5 5 decreased tumor growth/size 0.000308301141707502 0.00299569957030239 0.813741277509394 0.703703703703704 5.5 5 5 abnormal cell adhesion 0.000308301141707502 0.00299569957030239 0.813741277509394 0.703703703703704 5.5 5 5 abnormal heart valve morphology 0.0101890556391613 0.0513200503634665 0.813741277509394 0.703703703703704 5.5 5 5 thick interventricular septum 0.0101890556391613 0.0513200503634665 0.813741277509394 0.703703703703704 5.5 5 5 thrombocytopenia 4.20699208249577e-09 1.30811160065103e-07 0.813445908624635 0.703448275862069 5.5 5 5 decreased circulating HDL cholesterol level 3.48653452174237e-08 9.38707783627103e-07 0.813072082379863 0.703125 5.5 5 5 abnormal osteoclast physiology 9.08694765022272e-05 0.00106873675082407 0.813072082379863 0.703125 5.5 5 5 malocclusion 0.00283119878165912 0.0188557080840082 0.812583750798854 0.702702702702703 5.5 5 5 abnormal long bone metaphysis morphology 0.00283119878165912 0.0188557080840082 0.812583750798854 0.702702702702703 5.5 5 5 increased trabecular bone volume 0.00283119878165912 0.0188557080840082 0.812583750798854 0.702702702702703 5.5 5 5 abnormal respiratory electron transport chain 0.00283119878165912 0.0188557080840082 0.812583750798854 0.702702702702703 5.5 5 5 absent vitelline blood vessels 0.000236632595360612 0.00237827709478595 0.811487146546764 0.701754385964912 5.5 5 5 no abnormal phenotype detected 8.6463992194834e-94 1.43386120389766e-90 0.811124666697441 0.701440922190202 5.5 5 5 abnormal retinal pigmentation 6.26801279920373e-06 0.000100917034550287 0.810787588661809 0.701149425287356 5.5 5 5 epidermal hyperplasia 0.0001816365839611 0.00192674201536561 0.809458428680397 0.7 5.5 5 5 emphysema 0.00766839951360635 0.0419695132895397 0.809458428680397 0.7 5.5 5 5 increased circulating insulin level 1.18807648951694e-09 3.99370306442349e-08 0.809458428680397 0.7 5.5 5 5 decreased double-positive T cell number 1.46386453241986e-06 2.71743509283164e-05 0.809458428680397 0.7 5.5 5 5 decreased circulating alkaline phosphatase level 0.000619973902970452 0.005308726621821 0.809458428680397 0.7 5.5 5 5 decreased circulating phosphate level 0.00215201605074993 0.0149320500034601 0.809458428680397 0.7 5.5 5 5 abnormal hyoid bone morphology 0.028623263899465 0.114654378341255 0.809458428680397 0.7 5.5 5 5 kidney atrophy 0.028623263899465 0.114654378341255 0.809458428680397 0.7 5.5 5 5 abnormal induced retinal neovascularization 0.028623263899465 0.114654378341255 0.809458428680397 0.7 5.5 5 5 retarded hair growth 0.118782377769504 0.301809156998612 0.809458428680397 0.7 5.5 5 5 abnormal prostate gland epithelium morphology 0.118782377769504 0.301809156998612 0.809458428680397 0.7 5.5 5 5 abnormal grooming behavior 0.118782377769504 0.301809156998612 0.809458428680397 0.7 5.5 5 5 absent trophoblast giant cells 0.118782377769504 0.301809156998612 0.809458428680397 0.7 5.5 5 5 rhinitis 0.118782377769504 0.301809156998612 0.809458428680397 0.7 5.5 5 5 abnormal mammary gland physiology 0.118782377769504 0.301809156998612 0.809458428680397 0.7 5.5 5 5 decreased incidence of induced tumors 0.118782377769504 0.301809156998612 0.809458428680397 0.7 5.5 5 5 abnormal gland morphology 0.118782377769504 0.301809156998612 0.809458428680397 0.7 5.5 5 5 primary sex reversal 0.118782377769504 0.301809156998612 0.809458428680397 0.7 5.5 5 5 abnormal bone healing 0.118782377769504 0.301809156998612 0.809458428680397 0.7 5.5 5 5 abnormal scala media morphology 0.118782377769504 0.301809156998612 0.809458428680397 0.7 5.5 5 5 abnormal hypaxial muscle morphology 0.118782377769504 0.301809156998612 0.809458428680397 0.7 5.5 5 5 abnormal submandibular gland morphology 0.118782377769504 0.301809156998612 0.809458428680397 0.7 5.5 5 5 increased atrioventricular cushion size 0.118782377769504 0.301809156998612 0.809458428680397 0.7 5.5 5 5 abnormal pillar cell morphology 0.118782377769504 0.301809156998612 0.809458428680397 0.7 5.5 5 5 increased heart rate variability 0.118782377769504 0.301809156998612 0.809458428680397 0.7 5.5 5 5 abnormal reproductive system development 0.118782377769504 0.301809156998612 0.809458428680397 0.7 5.5 5 5 abnormal gas homeostasis 0.118782377769504 0.301809156998612 0.809458428680397 0.7 5.5 5 5 abnormal deltoid tuberosity morphology 0.118782377769504 0.301809156998612 0.809458428680397 0.7 5.5 5 5 absent coat pigmentation 0.118782377769504 0.301809156998612 0.809458428680397 0.7 5.5 5 5 abnormal gonadal fat pad morphology 0.118782377769504 0.301809156998612 0.809458428680397 0.7 5.5 5 5 increased susceptibility to atherosclerosis 0.118782377769504 0.301809156998612 0.809458428680397 0.7 5.5 5 5 tachypnea 0.118782377769504 0.301809156998612 0.809458428680397 0.7 5.5 5 5 absent axillary lymph nodes 0.118782377769504 0.301809156998612 0.809458428680397 0.7 5.5 5 5 ventricular premature beat 0.118782377769504 0.301809156998612 0.809458428680397 0.7 5.5 5 5 abnormal sperm principal piece morphology 0.118782377769504 0.301809156998612 0.809458428680397 0.7 5.5 5 5 acanthocytosis 0.118782377769504 0.301809156998612 0.809458428680397 0.7 5.5 5 5 fusion of atlas and odontoid process 0.118782377769504 0.301809156998612 0.809458428680397 0.7 5.5 5 5 decreased trabecular bone connectivity density 0.118782377769504 0.301809156998612 0.809458428680397 0.7 5.5 5 5 decreased macrophage cytokine production 0.118782377769504 0.301809156998612 0.809458428680397 0.7 5.5 5 5 decreased circulating lactate level 0.118782377769504 0.301809156998612 0.809458428680397 0.7 5.5 5 5 increased fatty acid oxidation 0.118782377769504 0.301809156998612 0.809458428680397 0.7 5.5 5 5 male infertility 3.66705264721014e-27 7.29743476794818e-25 0.80922853421045 0.699801192842942 5.5 5 5 decreased bone mineral density 5.52115950741021e-15 4.5779614248943e-13 0.808588978166239 0.699248120300752 5.5 5 5 retinal degeneration 2.88773022470595e-06 4.9369271023753e-05 0.807049326214086 0.697916666666667 5.5 5 5 delayed endochondral bone ossification 0.00163713603767083 0.0120129082410212 0.806769198020329 0.697674418604651 5.5 5 5 abnormal vascular development 0.000107054553720343 0.00122155138706125 0.80595427963849 0.696969696969697 5.5 5 5 abnormal aorta morphology 0.00578284016047944 0.0325080562693618 0.80595427963849 0.696969696969697 5.5 5 5 dextrocardia 0.00578284016047944 0.0325080562693618 0.80595427963849 0.696969696969697 5.5 5 5 abnormal ovarian folliculogenesis 0.00578284016047944 0.0325080562693618 0.80595427963849 0.696969696969697 5.5 5 5 abnormal QRS complex 0.00578284016047944 0.0325080562693618 0.80595427963849 0.696969696969697 5.5 5 5 cardiovascular system phenotype 0.00578284016047944 0.0325080562693618 0.80595427963849 0.696969696969697 5.5 5 5 abnormal muscle physiology 7.37949913622008e-06 0.000118048257886479 0.80556055502704 0.696629213483146 5.5 5 5 abnormal sleep pattern 0.00124644064324825 0.00970429139305174 0.804430736576792 0.695652173913043 5.5 5 5 abnormal cardiovascular development 0.021231897980028 0.0907042787088852 0.804430736576792 0.695652173913043 5.5 5 5 abnormal B cell morphology 0.021231897980028 0.0907042787088852 0.804430736576792 0.695652173913043 5.5 5 5 abnormal corneal stroma morphology 0.021231897980028 0.0907042787088852 0.804430736576792 0.695652173913043 5.5 5 5 abnormal lens morphology 9.52966430833307e-08 2.34703366009688e-06 0.804037948131198 0.6953125 5.5 5 5 increased hemoglobin content 0.000277716640967273 0.00274134977938925 0.803578585372791 0.694915254237288 5.5 5 5 decreased leukocyte cell number 4.40640798367932e-08 1.15988781580977e-06 0.801861842801227 0.693430656934307 5.5 5 5 hyperglycemia 1.11965232995437e-05 0.000167779227154307 0.801574093336107 0.693181818181818 5.5 5 5 increased hepatocyte apoptosis 0.0033055413143279 0.0209758520902823 0.80056328111248 0.692307692307692 5.5 5 5 decreased trabecular bone volume 0.0033055413143279 0.0209758520902823 0.80056328111248 0.692307692307692 5.5 5 5 absent corpus luteum 0.000724122883958884 0.00607350485682551 0.80056328111248 0.692307692307692 5.5 5 5 increased percent body fat/body weight 0.000724122883958884 0.00607350485682551 0.80056328111248 0.692307692307692 5.5 5 5 abnormal ureter morphology 0.0158190994217228 0.0736202241562869 0.80056328111248 0.692307692307692 5.5 5 5 increased leukemia incidence 0.0158190994217228 0.0736202241562869 0.80056328111248 0.692307692307692 5.5 5 5 decreased Peyer's patch number 0.0158190994217228 0.0736202241562869 0.80056328111248 0.692307692307692 5.5 5 5 absent common myeloid progenitor cells 0.0844216609731003 0.2480790096522 0.80056328111248 0.692307692307692 5.5 5 5 increased foot pad pigmentation 0.0844216609731003 0.2480790096522 0.80056328111248 0.692307692307692 5.5 5 5 small trigeminal ganglion 0.0844216609731003 0.2480790096522 0.80056328111248 0.692307692307692 5.5 5 5 abnormal digestion 0.0844216609731003 0.2480790096522 0.80056328111248 0.692307692307692 5.5 5 5 increased pituitary adenoma incidence 0.0844216609731003 0.2480790096522 0.80056328111248 0.692307692307692 5.5 5 5 lymphoid hypoplasia 0.0844216609731003 0.2480790096522 0.80056328111248 0.692307692307692 5.5 5 5 abnormal lung interstitium morphology 0.0844216609731003 0.2480790096522 0.80056328111248 0.692307692307692 5.5 5 5 muscle fatigue 0.0844216609731003 0.2480790096522 0.80056328111248 0.692307692307692 5.5 5 5 abnormal vestibulocochlear ganglion morphology 0.0844216609731003 0.2480790096522 0.80056328111248 0.692307692307692 5.5 5 5 small otic vesicle 0.0844216609731003 0.2480790096522 0.80056328111248 0.692307692307692 5.5 5 5 vestibular hair cell degeneration 0.0844216609731003 0.2480790096522 0.80056328111248 0.692307692307692 5.5 5 5 increased circulating thyroid-stimulating hormone level 0.0844216609731003 0.2480790096522 0.80056328111248 0.692307692307692 5.5 5 5 abnormal vertebral arch development 0.0844216609731003 0.2480790096522 0.80056328111248 0.692307692307692 5.5 5 5 small pituitary gland 0.0844216609731003 0.2480790096522 0.80056328111248 0.692307692307692 5.5 5 5 increased circulating thyroxine level 0.0844216609731003 0.2480790096522 0.80056328111248 0.692307692307692 5.5 5 5 orthokeratosis 0.0844216609731003 0.2480790096522 0.80056328111248 0.692307692307692 5.5 5 5 azoospermia 4.83440485372711e-09 1.47553154277867e-07 0.800003837869215 0.691823899371069 5.5 5 5 decreased circulating alanine transaminase level 0.000124797801836549 0.00137664980961603 0.799255171176022 0.691176470588235 5.5 5 5 decreased circulating calcium level 0.000552494024921456 0.00481376142554158 0.798945981554677 0.690909090909091 5.5 5 5 abnormal muscle morphology 0.00250468404665382 0.0170462423147781 0.798445388834405 0.69047619047619 5.5 5 5 abnormal microglial cell morphology 0.0118291483939337 0.0568599161930628 0.797495988847681 0.689655172413793 5.5 5 5 decreased retinal photoreceptor cell number 0.0118291483939337 0.0568599161930628 0.797495988847681 0.689655172413793 5.5 5 5 aphagia 0.0118291483939337 0.0568599161930628 0.797495988847681 0.689655172413793 5.5 5 5 short sternum 0.0118291483939337 0.0568599161930628 0.797495988847681 0.689655172413793 5.5 5 5 decreased T cell number 5.61630805310394e-09 1.68320075687904e-07 0.797248319285927 0.68944099378882 5.5 5 5 insulin resistance 1.29298296322776e-07 3.10753151790246e-06 0.797193907033724 0.689393939393939 5.5 5 5 pale liver 7.33372748152476e-05 0.000881287300014147 0.796957140206568 0.689189189189189 5.5 5 5 abnormal autopod morphology 0.0019002779202481 0.0135831647316585 0.796609882193406 0.688888888888889 5.5 5 5 irregular heartbeat 0.0019002779202481 0.0135831647316585 0.796609882193406 0.688888888888889 5.5 5 5 small placenta 0.0019002779202481 0.0135831647316585 0.796609882193406 0.688888888888889 5.5 5 5 abnormal metabolism 0.0019002779202481 0.0135831647316585 0.796609882193406 0.688888888888889 5.5 5 5 abnormal long bone morphology 0.000322222970480911 0.00311273646241268 0.796188618374161 0.688524590163934 5.5 5 5 abnormal enzyme/coenzyme activity 1.08940031675373e-08 3.13281304962418e-07 0.79546415193342 0.687898089171974 5.5 5 5 abnormal cardiovascular system morphology 0.00144338200921586 0.0110304539106742 0.795003813882532 0.6875 5.5 5 5 decreased circulating LDL cholesterol level 0.000246284112536709 0.00246036839331351 0.795003813882532 0.6875 5.5 5 5 abnormal tooth morphology 0.000246284112536709 0.00246036839331351 0.795003813882532 0.6875 5.5 5 5 abnormal vertebral body morphology 0.00887249079802057 0.047463055613067 0.795003813882532 0.6875 5.5 5 5 abnormal lumbar vertebrae morphology 0.00887249079802057 0.047463055613067 0.795003813882532 0.6875 5.5 5 5 abnormal serotonin level 0.00887249079802057 0.047463055613067 0.795003813882532 0.6875 5.5 5 5 abnormal hair follicle orientation 0.0609544577811182 0.194390017603245 0.795003813882532 0.6875 5.5 5 5 reduced male mating frequency 0.0609544577811182 0.194390017603245 0.795003813882532 0.6875 5.5 5 5 intraventricular hemorrhage 0.0609544577811182 0.194390017603245 0.795003813882532 0.6875 5.5 5 5 white spotting 0.0609544577811182 0.194390017603245 0.795003813882532 0.6875 5.5 5 5 increased intestinal adenocarcinoma incidence 0.0609544577811182 0.194390017603245 0.795003813882532 0.6875 5.5 5 5 abnormal epicardium morphology 0.0609544577811182 0.194390017603245 0.795003813882532 0.6875 5.5 5 5 abnormal molar crown morphology 0.0609544577811182 0.194390017603245 0.795003813882532 0.6875 5.5 5 5 small pancreas 0.0609544577811182 0.194390017603245 0.795003813882532 0.6875 5.5 5 5 abnormal amnion morphology 0.0609544577811182 0.194390017603245 0.795003813882532 0.6875 5.5 5 5 kidney degeneration 0.0609544577811182 0.194390017603245 0.795003813882532 0.6875 5.5 5 5 increased heart left ventricle size 0.0609544577811182 0.194390017603245 0.795003813882532 0.6875 5.5 5 5 decreased fibroblast apoptosis 0.0609544577811182 0.194390017603245 0.795003813882532 0.6875 5.5 5 5 increased mean corpuscular hemoglobin 5.9111314333699e-06 9.6104179349723e-05 0.794273782832135 0.686868686868687 5.5 5 5 abnormal glucose homeostasis 9.23939776871642e-10 3.2144058670884e-08 0.794209604278254 0.686813186813187 5.5 5 5 increased oxygen consumption 2.54145004990267e-05 0.000346403123240158 0.79332304471999 0.686046511627907 5.5 5 5 abnormal retina morphology 6.08136157274637e-11 2.54241796843808e-09 0.792938868911409 0.685714285714286 5.5 5 5 decreased bone mineralization 0.00667204224152999 0.0372541079142668 0.792938868911409 0.685714285714286 5.5 5 5 enlarged heart 6.71958755035706e-12 3.40805103145529e-10 0.792511638917383 0.685344827586207 5.5 5 5 diluted coat color 0.000835272339825163 0.00674590891336069 0.792327033364409 0.685185185185185 5.5 5 5 abnormal long bone epiphyseal plate proliferative zone 0.000835272339825163 0.00674590891336069 0.792327033364409 0.685185185185185 5.5 5 5 seminiferous tubule degeneration 0.000110295730234519 0.00124888080393844 0.792033687554204 0.684931506849315 5.5 5 5 abnormal circulating amino acid level 0.000636258846291922 0.00542948157856314 0.791199967883094 0.684210526315789 5.5 5 5 irregular coat pigmentation 0.0444894546205897 0.156068156984988 0.791199967883094 0.684210526315789 5.5 5 5 decreased grooming behavior 0.0444894546205897 0.156068156984988 0.791199967883094 0.684210526315789 5.5 5 5 increased malignant tumor incidence 0.0444894546205897 0.156068156984988 0.791199967883094 0.684210526315789 5.5 5 5 abnormal neurotransmitter level 0.0444894546205897 0.156068156984988 0.791199967883094 0.684210526315789 5.5 5 5 abnormal neural crest cell migration 0.0444894546205897 0.156068156984988 0.791199967883094 0.684210526315789 5.5 5 5 abnormal metatarsal bone morphology 0.0444894546205897 0.156068156984988 0.791199967883094 0.684210526315789 5.5 5 5 increased susceptibility to ischemic brain injury 0.0444894546205897 0.156068156984988 0.791199967883094 0.684210526315789 5.5 5 5 abnormal response to novelty 0.0444894546205897 0.156068156984988 0.791199967883094 0.684210526315789 5.5 5 5 abnormal optic vesicle formation 0.0444894546205897 0.156068156984988 0.791199967883094 0.684210526315789 5.5 5 5 abnormal blastocyst morphology 0.0444894546205897 0.156068156984988 0.791199967883094 0.684210526315789 5.5 5 5 shortened RR interval 0.0444894546205897 0.156068156984988 0.791199967883094 0.684210526315789 5.5 5 5 right-sided stomach 0.0444894546205897 0.156068156984988 0.791199967883094 0.684210526315789 5.5 5 5 enlarged spleen 2.93632390344327e-14 2.05749456614511e-12 0.790988643105348 0.684027777777778 5.5 5 5 increased erythrocyte cell number 0.000485047290296379 0.00424843357257832 0.790185608949911 0.683333333333333 5.5 5 5 abnormal incisor morphology 0.000485047290296379 0.00424843357257832 0.790185608949911 0.683333333333333 5.5 5 5 Leydig cell hyperplasia 0.00379709603081694 0.0238216302059449 0.789715540175997 0.682926829268293 5.5 5 5 abnormal hair follicle morphology 0.000370041770872983 0.00344748653575485 0.789267855629412 0.682539682539683 5.5 5 5 increased T cell number 2.91501134261652e-05 0.000393013046870384 0.788433534428958 0.681818181818182 5.5 5 5 osteoporosis 0.00287211724196479 0.019026342581591 0.788433534428958 0.681818181818182 5.5 5 5 cochlear hair cell degeneration 0.00287211724196479 0.019026342581591 0.788433534428958 0.681818181818182 5.5 5 5 abnormal amino acid level 0.00287211724196479 0.019026342581591 0.788433534428958 0.681818181818182 5.5 5 5 lethality, incomplete penetrance 0.00287211724196479 0.019026342581591 0.788433534428958 0.681818181818182 5.5 5 5 abnormal basisphenoid bone morphology 0.0327305894741457 0.127713476575588 0.788433534428958 0.681818181818182 5.5 5 5 abnormal facial nerve morphology 0.0327305894741457 0.127713476575588 0.788433534428958 0.681818181818182 5.5 5 5 increased body size 0.0327305894741457 0.127713476575588 0.788433534428958 0.681818181818182 5.5 5 5 abnormal germ layer development 0.0327305894741457 0.127713476575588 0.788433534428958 0.681818181818182 5.5 5 5 increased myocardial infarction size 0.0327305894741457 0.127713476575588 0.788433534428958 0.681818181818182 5.5 5 5 abnormal tracheal cartilage morphology 0.0327305894741457 0.127713476575588 0.788433534428958 0.681818181818182 5.5 5 5 decreased cardiac output 0.0327305894741457 0.127713476575588 0.788433534428958 0.681818181818182 5.5 5 5 abnormal retinal outer plexiform layer morphology 0.0327305894741457 0.127713476575588 0.788433534428958 0.681818181818182 5.5 5 5 abnormal sperm midpiece morphology 0.0327305894741457 0.127713476575588 0.788433534428958 0.681818181818182 5.5 5 5 abnormal skin morphology 0.000282493749151438 0.00277248572429891 0.788433534428958 0.681818181818182 5.5 5 5 reduced female fertility 1.70112587798386e-11 7.76431306694467e-10 0.787527288987085 0.681034482758621 5.5 5 5 decreased bone trabecula number 0.00217571895161756 0.0150754899502749 0.787315188990051 0.680851063829787 5.5 5 5 enlarged liver 1.01113074676857e-05 0.000152576337596111 0.786331045003814 0.68 5.5 5 5 decreased heart rate 1.01113074676857e-05 0.000152576337596111 0.786331045003814 0.68 5.5 5 5 increased body length 0.00165037340096881 0.0120566926135386 0.786331045003814 0.68 5.5 5 5 decreased oocyte number 0.00165037340096881 0.0120566926135386 0.786331045003814 0.68 5.5 5 5 decreased respiratory quotient 0.00165037340096881 0.0120566926135386 0.786331045003814 0.68 5.5 5 5 mandible hypoplasia 0.0242266718893377 0.098890186216117 0.786331045003814 0.68 5.5 5 5 spontaneous skin ulceration 0.0242266718893377 0.098890186216117 0.786331045003814 0.68 5.5 5 5 abnormal vertebrae development 0.0242266718893377 0.098890186216117 0.786331045003814 0.68 5.5 5 5 decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 0.0242266718893377 0.098890186216117 0.786331045003814 0.68 5.5 5 5 abnormal coat/ hair morphology 0.00125337244135395 0.00972781262985317 0.78545831354432 0.679245283018868 5.5 5 5 abnormal pancreatic islet morphology 0.00125337244135395 0.00972781262985317 0.78545831354432 0.679245283018868 5.5 5 5 lymphoid hyperplasia 0.0180189970498322 0.0827919738972549 0.784679089026915 0.678571428571429 5.5 5 5 abnormal ovulation 0.0180189970498322 0.0827919738972549 0.784679089026915 0.678571428571429 5.5 5 5 failure of blastocyst to hatch from the zona pellucida 0.0180189970498322 0.0827919738972549 0.784679089026915 0.678571428571429 5.5 5 5 abnormal retinal inner nuclear layer morphology 0.0180189970498322 0.0827919738972549 0.784679089026915 0.678571428571429 5.5 5 5 premature aging 0.0180189970498322 0.0827919738972549 0.784679089026915 0.678571428571429 5.5 5 5 increased triglyceride level 0.0180189970498322 0.0827919738972549 0.784679089026915 0.678571428571429 5.5 5 5 corneal vascularization 0.0180189970498322 0.0827919738972549 0.784679089026915 0.678571428571429 5.5 5 5 abnormal renal tubule epithelium morphology 0.0180189970498322 0.0827919738972549 0.784679089026915 0.678571428571429 5.5 5 5 abnormal mitotic spindle morphology 0.0180189970498322 0.0827919738972549 0.784679089026915 0.678571428571429 5.5 5 5 prolonged QRS complex duration 0.0180189970498322 0.0827919738972549 0.784679089026915 0.678571428571429 5.5 5 5 abnormal thoracic vertebrae morphology 0.00072515816783002 0.00607350485682551 0.783979107680772 0.677966101694915 5.5 5 5 atelectasis 0.000245193923658035 0.00245935437540065 0.78177071582815 0.676056338028169 5.5 5 5 abnormal hair follicle development 0.00757169956209284 0.0414859089442862 0.781330529614283 0.675675675675676 5.5 5 5 skin inflammation 0.00757169956209284 0.0414859089442862 0.781330529614283 0.675675675675676 5.5 5 5 obese 0.000143147043711108 0.00155832941457934 0.780924643624873 0.675324675324675 5.5 5 5 abnormal female reproductive system morphology 0.00570132455406674 0.0325080562693618 0.780549199084668 0.675 5.5 5 5 abnormal skin pigmentation 0.00570132455406674 0.0325080562693618 0.780549199084668 0.675 5.5 5 5 increased circulating creatinine level 6.41061464310948e-05 0.000783607072468542 0.779876891419651 0.674418604651163 5.5 5 5 abnormal male reproductive system morphology 0.00430174777954719 0.0264442311457543 0.779876891419651 0.674418604651163 5.5 5 5 abnormal double-strand DNA break repair 0.00430174777954719 0.0264442311457543 0.779876891419651 0.674418604651163 5.5 5 5 abnormal inner ear morphology 0.00325154162604778 0.02068595855446 0.779292276058767 0.673913043478261 5.5 5 5 decreased kidney weight 0.00186617174731403 0.0134164804087967 0.778325412192689 0.673076923076923 5.5 5 5 increased circulating calcium level 0.00141653887601611 0.0108419706279695 0.777921087303238 0.672727272727273 5.5 5 5 abnormal platelet physiology 0.00141653887601611 0.0108419706279695 0.777921087303238 0.672727272727273 5.5 5 5 decreased eosinophil cell number 0.000623450309371064 0.00532932180261348 0.776935545385202 0.671875 5.5 5 5 decreased B cell proliferation 0.000161329950188198 0.00173726515624737 0.775791984087903 0.670886075949367 5.5 5 5 decreased food intake 0.000161329950188198 0.00173726515624737 0.775791984087903 0.670886075949367 5.5 5 5 decreased litter size 2.64016025941393e-12 1.4276953576722e-10 0.773656251102769 0.669039145907473 5.5 5 5 abnormal osteoblast physiology 0.00208957264441152 0.0147665112300388 0.770912789219426 0.666666666666667 5.5 5 5 thin epidermis 0.0270791869868456 0.108907805383635 0.770912789219426 0.666666666666667 5.5 5 5 abnormal type II pneumocyte morphology 0.0270791869868456 0.108907805383635 0.770912789219426 0.666666666666667 5.5 5 5 abnormal bone trabecula morphology 0.0270791869868456 0.108907805383635 0.770912789219426 0.666666666666667 5.5 5 5 thin ventricular wall 8.08467610673618e-05 0.000969187075446085 0.770912789219425 0.666666666666667 5.5 5 5 increased circulating alanine transaminase level 0.00023643469758765 0.00237827709478595 0.770912789219425 0.666666666666667 5.5 5 5 abnormal osteoclast morphology 0.00364039283642095 0.0229834446208049 0.770912789219425 0.666666666666667 5.5 5 5 abnormal phalanx morphology 0.00364039283642095 0.0229834446208049 0.770912789219425 0.666666666666667 5.5 5 5 abnormal cartilage development 0.00481579588539824 0.0287963756368464 0.770912789219425 0.666666666666667 5.5 5 5 albuminuria 0.00481579588539824 0.0287963756368464 0.770912789219425 0.666666666666667 5.5 5 5 abnormal heart looping 0.00847433763920695 0.0457433969506792 0.770912789219425 0.666666666666667 5.5 5 5 abnormal response to injury 0.00847433763920695 0.0457433969506792 0.770912789219425 0.666666666666667 5.5 5 5 abnormal circulating hormone level 0.00847433763920695 0.0457433969506792 0.770912789219425 0.666666666666667 5.5 5 5 dilated heart atrium 0.0150517920731028 0.0702464029678111 0.770912789219425 0.666666666666667 5.5 5 5 increased osteoblast cell number 0.0150517920731028 0.0702464029678111 0.770912789219425 0.666666666666667 5.5 5 5 head tossing 0.0150517920731028 0.0702464029678111 0.770912789219425 0.666666666666667 5.5 5 5 abnormal body weight 0.0365584130050276 0.138944312223081 0.770912789219425 0.666666666666667 5.5 5 5 abnormal primitive streak formation 0.0365584130050276 0.138944312223081 0.770912789219425 0.666666666666667 5.5 5 5 abnormal cardiac muscle contractility 0.0365584130050276 0.138944312223081 0.770912789219425 0.666666666666667 5.5 5 5 abnormal impulse conducting system conduction 0.0365584130050276 0.138944312223081 0.770912789219425 0.666666666666667 5.5 5 5 prolonged QT interval 0.0365584130050276 0.138944312223081 0.770912789219425 0.666666666666667 5.5 5 5 abnormal tumor morphology 0.0365584130050276 0.138944312223081 0.770912789219425 0.666666666666667 5.5 5 5 increased hemangiosarcoma incidence 0.0365584130050276 0.138944312223081 0.770912789219425 0.666666666666667 5.5 5 5 cortical renal glomerulopathies 0.0679033475936597 0.214080579390657 0.770912789219425 0.666666666666667 5.5 5 5 right pulmonary isomerism 0.0679033475936597 0.214080579390657 0.770912789219425 0.666666666666667 5.5 5 5 absent spleen 0.0679033475936597 0.214080579390657 0.770912789219425 0.666666666666667 5.5 5 5 eye inflammation 0.0679033475936597 0.214080579390657 0.770912789219425 0.666666666666667 5.5 5 5 acidosis 0.0679033475936597 0.214080579390657 0.770912789219425 0.666666666666667 5.5 5 5 increased circulating renin level 0.0679033475936597 0.214080579390657 0.770912789219425 0.666666666666667 5.5 5 5 decreased activity of thyroid 0.0679033475936597 0.214080579390657 0.770912789219425 0.666666666666667 5.5 5 5 abnormal neutrophil morphology 0.0679033475936597 0.214080579390657 0.770912789219425 0.666666666666667 5.5 5 5 increased gastrointestinal tumor incidence 0.0679033475936597 0.214080579390657 0.770912789219425 0.666666666666667 5.5 5 5 abnormal aerobic respiration 0.0679033475936597 0.214080579390657 0.770912789219425 0.666666666666667 5.5 5 5 abnormal metanephric mesenchyme morphology 0.0679033475936597 0.214080579390657 0.770912789219425 0.666666666666667 5.5 5 5 increased adipocyte glucose uptake 0.0679033475936597 0.214080579390657 0.770912789219425 0.666666666666667 5.5 5 5 abnormal adipose tissue distribution 0.13137582066295 0.329598944931001 0.770912789219425 0.666666666666667 5.5 5 5 abnormal rectum morphology 0.13137582066295 0.329598944931001 0.770912789219425 0.666666666666667 5.5 5 5 amyloidosis 0.13137582066295 0.329598944931001 0.770912789219425 0.666666666666667 5.5 5 5 abnormal pilomotor reflex 0.13137582066295 0.329598944931001 0.770912789219425 0.666666666666667 5.5 5 5 increased growth rate 0.13137582066295 0.329598944931001 0.770912789219425 0.666666666666667 5.5 5 5 abnormal gastrocnemius morphology 0.13137582066295 0.329598944931001 0.770912789219425 0.666666666666667 5.5 5 5 abnormal aorta elastic fiber morphology 0.13137582066295 0.329598944931001 0.770912789219425 0.666666666666667 5.5 5 5 abnormal alisphenoid bone morphology 0.13137582066295 0.329598944931001 0.770912789219425 0.666666666666667 5.5 5 5 increased fear-related response 0.13137582066295 0.329598944931001 0.770912789219425 0.666666666666667 5.5 5 5 absent ovary 0.13137582066295 0.329598944931001 0.770912789219425 0.666666666666667 5.5 5 5 impaired sperm capacitation 0.13137582066295 0.329598944931001 0.770912789219425 0.666666666666667 5.5 5 5 delayed somite formation 0.13137582066295 0.329598944931001 0.770912789219425 0.666666666666667 5.5 5 5 absent cochlear hair cells 0.13137582066295 0.329598944931001 0.770912789219425 0.666666666666667 5.5 5 5 decreased cochlear nerve compound action potential 0.13137582066295 0.329598944931001 0.770912789219425 0.666666666666667 5.5 5 5 small parietal bone 0.13137582066295 0.329598944931001 0.770912789219425 0.666666666666667 5.5 5 5 decreased renal glomerular filtration rate 0.13137582066295 0.329598944931001 0.770912789219425 0.666666666666667 5.5 5 5 reduced cerebellar foliation 0.13137582066295 0.329598944931001 0.770912789219425 0.666666666666667 5.5 5 5 decreased prostaglandin level 0.13137582066295 0.329598944931001 0.770912789219425 0.666666666666667 5.5 5 5 decreased compensatory feeding amount 0.13137582066295 0.329598944931001 0.770912789219425 0.666666666666667 5.5 5 5 distorted hair follicle pattern 0.18787837959628 0.425247924700407 0.770912789219425 0.666666666666667 5.5 5 5 abnormal head movements 0.18787837959628 0.425247924700407 0.770912789219425 0.666666666666667 5.5 5 5 crypts of Lieberkuhn abscesses 0.18787837959628 0.425247924700407 0.770912789219425 0.666666666666667 5.5 5 5 thick tail 0.18787837959628 0.425247924700407 0.770912789219425 0.666666666666667 5.5 5 5 abnormal sympathetic neuron morphology 0.18787837959628 0.425247924700407 0.770912789219425 0.666666666666667 5.5 5 5 absent enteric neurons 0.18787837959628 0.425247924700407 0.770912789219425 0.666666666666667 5.5 5 5 wavy vibrissae 0.18787837959628 0.425247924700407 0.770912789219425 0.666666666666667 5.5 5 5 abnormal lens vesicle development 0.18787837959628 0.425247924700407 0.770912789219425 0.666666666666667 5.5 5 5 abnormal lung volume 0.18787837959628 0.425247924700407 0.770912789219425 0.666666666666667 5.5 5 5 abnormal thymus lobule morphology 0.18787837959628 0.425247924700407 0.770912789219425 0.666666666666667 5.5 5 5 abnormal postural reflex 0.18787837959628 0.425247924700407 0.770912789219425 0.666666666666667 5.5 5 5 genetic imprinting 0.18787837959628 0.425247924700407 0.770912789219425 0.666666666666667 5.5 5 5 yellow coat color 0.18787837959628 0.425247924700407 0.770912789219425 0.666666666666667 5.5 5 5 enlarged otoliths 0.18787837959628 0.425247924700407 0.770912789219425 0.666666666666667 5.5 5 5 absent posterior semicircular canal 0.18787837959628 0.425247924700407 0.770912789219425 0.666666666666667 5.5 5 5 priapism 0.18787837959628 0.425247924700407 0.770912789219425 0.666666666666667 5.5 5 5 premature bone ossification 0.18787837959628 0.425247924700407 0.770912789219425 0.666666666666667 5.5 5 5 abnormal thymus physiology 0.18787837959628 0.425247924700407 0.770912789219425 0.666666666666667 5.5 5 5 decreased muscle weight 0.18787837959628 0.425247924700407 0.770912789219425 0.666666666666667 5.5 5 5 absent cochlear outer hair cells 0.18787837959628 0.425247924700407 0.770912789219425 0.666666666666667 5.5 5 5 decreased cochlear hair cell number 0.18787837959628 0.425247924700407 0.770912789219425 0.666666666666667 5.5 5 5 abnormal hair cell mechanoelectric transduction 0.18787837959628 0.425247924700407 0.770912789219425 0.666666666666667 5.5 5 5 liver hyperplasia 0.18787837959628 0.425247924700407 0.770912789219425 0.666666666666667 5.5 5 5 hemothorax 0.18787837959628 0.425247924700407 0.770912789219425 0.666666666666667 5.5 5 5 increased tidal volume 0.18787837959628 0.425247924700407 0.770912789219425 0.666666666666667 5.5 5 5 absent cervical lymph nodes 0.18787837959628 0.425247924700407 0.770912789219425 0.666666666666667 5.5 5 5 iris coloboma 0.18787837959628 0.425247924700407 0.770912789219425 0.666666666666667 5.5 5 5 fusion of atlas and occipital bones 0.18787837959628 0.425247924700407 0.770912789219425 0.666666666666667 5.5 5 5 decreased susceptibility to parasitic infection induced morbidity/mortality 0.18787837959628 0.425247924700407 0.770912789219425 0.666666666666667 5.5 5 5 abnormal pulmonary alveolar parenchyma morphology 0.18787837959628 0.425247924700407 0.770912789219425 0.666666666666667 5.5 5 5 increased myeloid cell number 0.18787837959628 0.425247924700407 0.770912789219425 0.666666666666667 5.5 5 5 decreased bone mineral density of femur 0.18787837959628 0.425247924700407 0.770912789219425 0.666666666666667 5.5 5 5 enhanced leukocyte tethering or rolling 0.18787837959628 0.425247924700407 0.770912789219425 0.666666666666667 5.5 5 5 abnormal cartilage morphology 0.00638191999914317 0.0357545630582627 0.770912789219425 0.666666666666667 5.5 5 5 disheveled coat 0.00638191999914317 0.0357545630582627 0.770912789219425 0.666666666666667 5.5 5 5 abnormal hair cycle 0.0201506461545882 0.0892693362591953 0.770912789219425 0.666666666666667 5.5 5 5 abnormal estrous cycle 0.0201506461545882 0.0892693362591953 0.770912789219425 0.666666666666667 5.5 5 5 disorganized myocardium 0.0201506461545882 0.0892693362591953 0.770912789219425 0.666666666666667 5.5 5 5 abnormal spleen marginal zone morphology 0.0201506461545882 0.0892693362591953 0.770912789219425 0.666666666666667 5.5 5 5 abnormal erythrocyte physiology 0.0496406450719654 0.166753686180302 0.770912789219425 0.666666666666667 5.5 5 5 abnormal clavicle morphology 0.0496406450719654 0.166753686180302 0.770912789219425 0.666666666666667 5.5 5 5 abnormal tumor vascularization 0.0496406450719654 0.166753686180302 0.770912789219425 0.666666666666667 5.5 5 5 abnormal epidermis stratum spinosum morphology 0.093801808934749 0.266486432166307 0.770912789219425 0.666666666666667 5.5 5 5 no suckling reflex 0.093801808934749 0.266486432166307 0.770912789219425 0.666666666666667 5.5 5 5 abnormal apical ectodermal ridge morphology 0.093801808934749 0.266486432166307 0.770912789219425 0.666666666666667 5.5 5 5 increased airway responsiveness 0.093801808934749 0.266486432166307 0.770912789219425 0.666666666666667 5.5 5 5 abnormal bronchus morphology 0.093801808934749 0.266486432166307 0.770912789219425 0.666666666666667 5.5 5 5 abnormal lymph node B cell domain morphology 0.093801808934749 0.266486432166307 0.770912789219425 0.666666666666667 5.5 5 5 abnormal pericyte morphology 0.093801808934749 0.266486432166307 0.770912789219425 0.666666666666667 5.5 5 5 abnormal rostral migratory stream morphology 0.093801808934749 0.266486432166307 0.770912789219425 0.666666666666667 5.5 5 5 absent chorion 0.093801808934749 0.266486432166307 0.770912789219425 0.666666666666667 5.5 5 5 ostium primum atrial septal defect 0.093801808934749 0.266486432166307 0.770912789219425 0.666666666666667 5.5 5 5 abnormal branching involved in lung morphogenesis 0.093801808934749 0.266486432166307 0.770912789219425 0.666666666666667 5.5 5 5 decreased brown adipose tissue mass 0.093801808934749 0.266486432166307 0.770912789219425 0.666666666666667 5.5 5 5 decreased lymphocyte cell number 3.73968777462917e-06 6.28545495904733e-05 0.767901411136537 0.6640625 5.5 5 5 increased bone mineral density 1.40054633385161e-05 0.000205537404451674 0.767501670683056 0.663716814159292 5.5 5 5 abnormal colon morphology 0.00176146159836296 0.0128118003682101 0.764379629988752 0.661016949152542 5.5 5 5 syndactyly 0.00176146159836296 0.0128118003682101 0.764379629988752 0.661016949152542 5.5 5 5 short mandible 0.00231942412829677 0.0159380318208238 0.76402963931568 0.660714285714286 5.5 5 5 abnormal seminal vesicle morphology 0.00231942412829677 0.0159380318208238 0.76402963931568 0.660714285714286 5.5 5 5 abnormal placenta development 0.00305772595334751 0.0198333593453766 0.763640027056978 0.660377358490566 5.5 5 5 increased monocyte cell number 5.85693101624615e-05 0.000723624671418141 0.763203661327231 0.66 5.5 5 5 abnormal tibia morphology 0.00533594805775634 0.0314530113594049 0.762711589334112 0.659574468085106 5.5 5 5 increased systemic arterial blood pressure 0.00533594805775634 0.0314530113594049 0.762711589334112 0.659574468085106 5.5 5 5 small ovary 0.000130336861100026 0.00143457053976246 0.762441220107124 0.659340659340659 5.5 5 5 abnormal circadian rhythm 0.00706570015220646 0.0387989605488158 0.762152416614659 0.659090909090909 5.5 5 5 embryonic lethality, incomplete penetrance 0.00706570015220646 0.0387989605488158 0.762152416614659 0.659090909090909 5.5 5 5 circling 0.000222639005881869 0.00225586365430203 0.761843226993315 0.658823529411765 5.5 5 5 increased bone marrow cell number 0.0124625190610774 0.0597888450615814 0.760769199887591 0.657894736842105 5.5 5 5 weight loss 1.86212946126081e-07 4.26916777408873e-06 0.759899749373434 0.657142857142857 5.5 5 5 abnormal embryonic hematopoiesis 0.0222025702846916 0.0918186094483298 0.758867276887872 0.65625 5.5 5 5 abnormal parietal bone morphology 0.0297797094960395 0.118808383915635 0.757621189405297 0.655172413793103 5.5 5 5 abnormal embryonic erythropoiesis 0.0297797094960395 0.118808383915635 0.757621189405297 0.655172413793103 5.5 5 5 abnormal CD8-positive, alpha-beta T cell physiology 0.0297797094960395 0.118808383915635 0.757621189405297 0.655172413793103 5.5 5 5 decreased bone strength 0.0297797094960395 0.118808383915635 0.757621189405297 0.655172413793103 5.5 5 5 hydronephrosis 0.000320566251691442 0.00310275700810297 0.757146489411936 0.654761904761905 5.5 5 5 arrest of spermatogenesis 0.000320566251691442 0.00310275700810297 0.757146489411936 0.654761904761905 5.5 5 5 abnormal cardiovascular system physiology 7.26364255813181e-06 0.000116569747505502 0.756421947316805 0.654135338345865 5.5 5 5 abnormal lipid homeostasis 9.44617698465369e-06 0.000147782171379409 0.756087543272898 0.653846153846154 5.5 5 5 abnormal female meiosis 0.00443722054759215 0.0272196944812219 0.756087543272898 0.653846153846154 5.5 5 5 abnormal stomach morphology 0.0401076421059438 0.150139593285982 0.756087543272898 0.653846153846154 5.5 5 5 small seminal vesicle 0.0401076421059438 0.150139593285982 0.756087543272898 0.653846153846154 5.5 5 5 abnormal forelimb morphology 0.00774877262168031 0.0423627953767687 0.754153815540742 0.652173913043478 5.5 5 5 blistering 0.0542906360256164 0.179108696437295 0.754153815540742 0.652173913043478 5.5 5 5 bidirectional circling 0.0542906360256164 0.179108696437295 0.754153815540742 0.652173913043478 5.5 5 5 failure of embryo implantation 0.0542906360256164 0.179108696437295 0.754153815540742 0.652173913043478 5.5 5 5 increased susceptibility to age related obesity 0.0542906360256164 0.179108696437295 0.754153815540742 0.652173913043478 5.5 5 5 abnormal crista ampullaris morphology 0.0542906360256164 0.179108696437295 0.754153815540742 0.652173913043478 5.5 5 5 abnormal neuron differentiation 4.58825902947858e-05 0.000583800221781482 0.753704914460063 0.651785714285714 5.5 5 5 abnormal renal glomerulus morphology 5.97571625897505e-05 0.000735870999712892 0.753231303228154 0.651376146788991 5.5 5 5 abnormal homeostasis 0.010264908142389 0.0515317033384311 0.752984584818974 0.651162790697674 5.5 5 5 abnormal blood circulation 0.010264908142389 0.0515317033384311 0.752984584818974 0.651162790697674 5.5 5 5 decreased oxygen consumption 0.010264908142389 0.0515317033384311 0.752984584818974 0.651162790697674 5.5 5 5 increased circulating aspartate transaminase level 0.00212600341406867 0.0148484296268703 0.752557722809439 0.650793650793651 5.5 5 5 abnormal lipid level 0.000458963239509357 0.00403718933860632 0.752336577431005 0.650602409638554 5.5 5 5 female infertility 5.95696853617225e-10 2.11685131910407e-08 0.752074694746018 0.650375939849624 5.5 5 5 abnormal basioccipital bone morphology 0.0739552373883927 0.228242745662068 0.75163996948894 0.65 5.5 5 5 small gonad 0.0739552373883927 0.228242745662068 0.75163996948894 0.65 5.5 5 5 abnormal hair texture 0.0739552373883927 0.228242745662068 0.75163996948894 0.65 5.5 5 5 abnormal lens epithelium morphology 0.0739552373883927 0.228242745662068 0.75163996948894 0.65 5.5 5 5 abnormal neuron proliferation 0.0739552373883927 0.228242745662068 0.75163996948894 0.65 5.5 5 5 abnormal heart electrocardiography waveform feature 0.0739552373883927 0.228242745662068 0.75163996948894 0.65 5.5 5 5 decreased muscle cell glucose uptake 0.0739552373883927 0.228242745662068 0.75163996948894 0.65 5.5 5 5 increased macrophage cell number 0.00367594870403643 0.0231785105229167 0.750625610555756 0.649122807017544 5.5 5 5 increased granulocyte number 0.00102767256330808 0.00808966930768626 0.750077308429711 0.648648648648649 5.5 5 5 increased brown adipose tissue amount 0.0181227054420323 0.0827919738972549 0.750077308429711 0.648648648648649 5.5 5 5 increased circulating phosphate level 0.0181227054420323 0.0827919738972549 0.750077308429711 0.648648648648649 5.5 5 5 abnormal B cell differentiation 0.000293415609802178 0.00287350917079889 0.749733866438672 0.648351648351648 5.5 5 5 abnormal mandible morphology 0.00484116625928222 0.0288786596402027 0.749498545074441 0.648148148148148 5.5 5 5 abnormal small intestine morphology 0.00484116625928222 0.0288786596402027 0.749498545074441 0.648148148148148 5.5 5 5 abnormal ovary morphology 0.00134602045823628 0.0103660244268196 0.749196936001977 0.647887323943662 5.5 5 5 decreased liver weight 0.00134602045823628 0.0103660244268196 0.749196936001977 0.647887323943662 5.5 5 5 teratozoospermia 0.000382985855947958 0.00356141052960951 0.74901185770751 0.647727272727273 5.5 5 5 short maxilla 0.0241678158058415 0.098890186216117 0.748238883654148 0.647058823529412 5.5 5 5 lung hemorrhage 0.0241678158058415 0.098890186216117 0.748238883654148 0.647058823529412 5.5 5 5 abnormal cranial suture morphology 0.101568358519382 0.266486432166307 0.748238883654148 0.647058823529412 5.5 5 5 abnormal testis development 0.101568358519382 0.266486432166307 0.748238883654148 0.647058823529412 5.5 5 5 abnormal melanosome morphology 0.101568358519382 0.266486432166307 0.748238883654148 0.647058823529412 5.5 5 5 increased circulating magnesium level 0.101568358519382 0.266486432166307 0.748238883654148 0.647058823529412 5.5 5 5 deafness 0.000187712835136932 0.00198696032937497 0.747551795606715 0.646464646464647 5.5 5 5 oligodactyly 0.00842784287313258 0.0457433969506792 0.746821764556318 0.645833333333333 5.5 5 5 increased sensitivity to xenobiotic induced morbidity/mortality 9.23544223464487e-05 0.00108363974333392 0.74638374592608 0.645454545454546 5.5 5 5 inner cell mass degeneration 0.0323250834873601 0.127713476575588 0.746044634728476 0.645161290322581 5.5 5 5 decreased insulin secretion 0.000415917838950071 0.00380366038378052 0.745215696245444 0.644444444444444 5.5 5 5 abnormal ovarian follicle morphology 0.0111436516357963 0.0549334995856956 0.745215696245444 0.644444444444444 5.5 5 5 thick epidermis 0.00191204152528309 0.0136476421639647 0.743380189604446 0.642857142857143 5.5 5 5 abnormal circulating cholesterol level 0.0433875288734698 0.156068156984988 0.743380189604446 0.642857142857143 5.5 5 5 abnormal jaw morphology 0.0433875288734698 0.156068156984988 0.743380189604446 0.642857142857143 5.5 5 5 reddish skin 0.0433875288734698 0.156068156984988 0.743380189604446 0.642857142857143 5.5 5 5 absent atrioventricular cushions 0.141028624439359 0.350389803536863 0.743380189604446 0.642857142857143 5.5 5 5 abnormal fluid regulation 0.141028624439359 0.350389803536863 0.743380189604446 0.642857142857143 5.5 5 5 abnormal spleen periarteriolar lymphoid sheath morphology 0.141028624439359 0.350389803536863 0.743380189604446 0.642857142857143 5.5 5 5 absent otoliths 0.141028624439359 0.350389803536863 0.743380189604446 0.642857142857143 5.5 5 5 intestinal obstruction 0.141028624439359 0.350389803536863 0.743380189604446 0.642857142857143 5.5 5 5 abnormal ventral body wall morphology 0.141028624439359 0.350389803536863 0.743380189604446 0.642857142857143 5.5 5 5 enlarged stomach 0.141028624439359 0.350389803536863 0.743380189604446 0.642857142857143 5.5 5 5 abnormal pancreas development 0.141028624439359 0.350389803536863 0.743380189604446 0.642857142857143 5.5 5 5 abnormal iris pigmentation 0.141028624439359 0.350389803536863 0.743380189604446 0.642857142857143 5.5 5 5 increased circulating triglyceride level 1.20964105512204e-05 0.000180178570336292 0.741671269628344 0.641379310344828 5.5 5 5 small lens 0.0195842716001316 0.0876070064096332 0.741262297326371 0.641025641025641 5.5 5 5 abnormal cochlear outer hair cell morphology 0.0584815083218099 0.189875747266469 0.740076277650648 0.64 5.5 5 5 decreased placenta weight 0.0584815083218099 0.189875747266469 0.740076277650648 0.64 5.5 5 5 impaired conditioned place preference behavior 0.0584815083218099 0.189875747266469 0.740076277650648 0.64 5.5 5 5 increased double-negative T cell number 0.00430549291016301 0.0264442311457543 0.739318002776006 0.639344262295082 5.5 5 5 abnormal limb bone morphology 0.0260426990786531 0.104993863789545 0.738791423001949 0.638888888888889 5.5 5 5 short radius 0.0260426990786531 0.104993863789545 0.738791423001949 0.638888888888889 5.5 5 5 abnormal trophoblast giant cell morphology 0.0260426990786531 0.104993863789545 0.738791423001949 0.638888888888889 5.5 5 5 head tilt 0.0260426990786531 0.104993863789545 0.738791423001949 0.638888888888889 5.5 5 5 abnormal coat appearance 0.00269725813686168 0.0181091217690781 0.737394841862059 0.63768115942029 5.5 5 5 increased lymphocyte cell number 0.00269725813686168 0.0181091217690781 0.737394841862059 0.63768115942029 5.5 5 5 increased spleen weight 0.000151192994990485 0.00163518510886449 0.736801603855734 0.63716814159292 5.5 5 5 abnormal gametogenesis 0.0158635221252085 0.0736890967067342 0.735871298800361 0.636363636363636 5.5 5 5 abnormal photoreceptor outer segment morphology 0.0158635221252085 0.0736890967067342 0.735871298800361 0.636363636363636 5.5 5 5 abnormal abdominal fat pad morphology 0.0792332423681499 0.236463935681791 0.735871298800361 0.636363636363636 5.5 5 5 abnormal long bone epiphysis morphology 0.0792332423681499 0.236463935681791 0.735871298800361 0.636363636363636 5.5 5 5 prolonged PR interval 0.0792332423681499 0.236463935681791 0.735871298800361 0.636363636363636 5.5 5 5 abnormal occipital bone morphology 0.0792332423681499 0.236463935681791 0.735871298800361 0.636363636363636 5.5 5 5 decreased atrioventricular cushion size 0.198882316196694 0.426604375310863 0.735871298800361 0.636363636363636 5.5 5 5 abnormal awl hair morphology 0.198882316196694 0.426604375310863 0.735871298800361 0.636363636363636 5.5 5 5 abnormal stomach epithelium morphology 0.198882316196694 0.426604375310863 0.735871298800361 0.636363636363636 5.5 5 5 abnormal glossopharyngeal ganglion morphology 0.198882316196694 0.426604375310863 0.735871298800361 0.636363636363636 5.5 5 5 abnormal food preference 0.198882316196694 0.426604375310863 0.735871298800361 0.636363636363636 5.5 5 5 secondary sex reversal 0.198882316196694 0.426604375310863 0.735871298800361 0.636363636363636 5.5 5 5 abnormal primary sex determination 0.198882316196694 0.426604375310863 0.735871298800361 0.636363636363636 5.5 5 5 abnormal vestibular ganglion morphology 0.198882316196694 0.426604375310863 0.735871298800361 0.636363636363636 5.5 5 5 decreased post-tetanic potentiation 0.198882316196694 0.426604375310863 0.735871298800361 0.636363636363636 5.5 5 5 abnormal nerve fiber response 0.198882316196694 0.426604375310863 0.735871298800361 0.636363636363636 5.5 5 5 abnormal ureter development 0.198882316196694 0.426604375310863 0.735871298800361 0.636363636363636 5.5 5 5 pathological neovascularization 0.198882316196694 0.426604375310863 0.735871298800361 0.636363636363636 5.5 5 5 abnormal crista ampullaris neuroepithelium morphology 0.198882316196694 0.426604375310863 0.735871298800361 0.636363636363636 5.5 5 5 increased motor neuron number 0.198882316196694 0.426604375310863 0.735871298800361 0.636363636363636 5.5 5 5 increased circulating triiodothyronine level 0.198882316196694 0.426604375310863 0.735871298800361 0.636363636363636 5.5 5 5 abnormal platelet aggregation 0.198882316196694 0.426604375310863 0.735871298800361 0.636363636363636 5.5 5 5 abnormal palate development 0.198882316196694 0.426604375310863 0.735871298800361 0.636363636363636 5.5 5 5 abnormal aorta smooth muscle morphology 0.198882316196694 0.426604375310863 0.735871298800361 0.636363636363636 5.5 5 5 abnormal palatal shelf elevation 0.198882316196694 0.426604375310863 0.735871298800361 0.636363636363636 5.5 5 5 aberrant origin of the right subclavian artery 0.198882316196694 0.426604375310863 0.735871298800361 0.636363636363636 5.5 5 5 decreased core body temperature 0.198882316196694 0.426604375310863 0.735871298800361 0.636363636363636 5.5 5 5 chylous ascites 0.198882316196694 0.426604375310863 0.735871298800361 0.636363636363636 5.5 5 5 decreased systemic arterial blood pressure 0.0347164321549719 0.132754996134501 0.735871298800361 0.636363636363636 5.5 5 5 skin lesions 0.00462166413914605 0.0279377631740602 0.734202656399453 0.634920634920635 5.5 5 5 cachexia 0.000330757938732594 0.0031889936922377 0.733849674353107 0.634615384615385 5.5 5 5 abnormal cholesterol homeostasis 0.0209916723460127 0.0907042787088852 0.733307287306283 0.634146341463415 5.5 5 5 abnormal T cell differentiation 0.00042945235598101 0.00383771641198662 0.732748789753117 0.633663366336634 5.5 5 5 arrested T cell differentiation 0.0464117279949095 0.156494736907147 0.732367149758454 0.633333333333333 5.5 5 5 increased sarcoma incidence 0.0128514417450547 0.0614768487323532 0.731580504055169 0.63265306122449 5.5 5 5 abnormal respiratory system physiology 0.0128514417450547 0.0614768487323532 0.731580504055169 0.63265306122449 5.5 5 5 increased fluid intake 0.0128514417450547 0.0614768487323532 0.731580504055169 0.63265306122449 5.5 5 5 abnormal compact bone morphology 0.0278258820950976 0.111730236822527 0.730338431892087 0.631578947368421 5.5 5 5 abnormal ear morphology 0.108041449833208 0.280682095519692 0.730338431892087 0.631578947368421 5.5 5 5 maternal imprinting 0.108041449833208 0.280682095519692 0.730338431892087 0.631578947368421 5.5 5 5 increased liver adenoma incidence 0.108041449833208 0.280682095519692 0.730338431892087 0.631578947368421 5.5 5 5 oliguria 0.108041449833208 0.280682095519692 0.730338431892087 0.631578947368421 5.5 5 5 increased left ventricle weight 0.108041449833208 0.280682095519692 0.730338431892087 0.631578947368421 5.5 5 5 absent amnion 0.108041449833208 0.280682095519692 0.730338431892087 0.631578947368421 5.5 5 5 increased circulating VLDL cholesterol level 0.108041449833208 0.280682095519692 0.730338431892087 0.631578947368421 5.5 5 5 decreased circulating magnesium level 0.108041449833208 0.280682095519692 0.730338431892087 0.631578947368421 5.5 5 5 decreased liver glycogen level 0.108041449833208 0.280682095519692 0.730338431892087 0.631578947368421 5.5 5 5 abnormal palate morphology 0.0622560158084109 0.198159743216151 0.728084300929457 0.62962962962963 5.5 5 5 decreased bone ossification 0.0622560158084109 0.198159743216151 0.728084300929457 0.62962962962963 5.5 5 5 decreased IgM level 0.000772045189965708 0.00636969290228756 0.727201239315231 0.628865979381443 5.5 5 5 ovary cysts 0.0369576031033888 0.139926998051263 0.726860629835458 0.628571428571429 5.5 5 5 abnormal intestinal goblet cell morphology 0.0369576031033888 0.139926998051263 0.726860629835458 0.628571428571429 5.5 5 5 impaired adaptive thermogenesis 0.0369576031033888 0.139926998051263 0.726860629835458 0.628571428571429 5.5 5 5 improved glucose tolerance 2.7562823000882e-06 4.79458197305551e-05 0.725680661280531 0.627551020408163 5.5 5 5 increased lung adenocarcinoma incidence 0.0136758565648226 0.0649211702385422 0.725564978088871 0.627450980392157 5.5 5 5 abnormal gluconeogenesis 0.0136758565648226 0.0649211702385422 0.725564978088871 0.627450980392157 5.5 5 5 increased T cell proliferation 0.000519915184772333 0.00453785621796904 0.724081638472451 0.626168224299065 5.5 5 5 increased liver weight 0.00168461687041176 0.0122888107482383 0.722730739893211 0.625 5.5 5 5 decreased body height 0.0838443410599309 0.2480790096522 0.722730739893211 0.625 5.5 5 5 abnormal vasodilation 0.0838443410599309 0.2480790096522 0.722730739893211 0.625 5.5 5 5 small lymph nodes 0.0838443410599309 0.2480790096522 0.722730739893211 0.625 5.5 5 5 abnormal osteoblast morphology 0.0838443410599309 0.2480790096522 0.722730739893211 0.625 5.5 5 5 decreased fatty acid level 0.0838443410599309 0.2480790096522 0.722730739893211 0.625 5.5 5 5 hypopigmentation 0.0838443410599309 0.2480790096522 0.722730739893211 0.625 5.5 5 5 abnormal inner cell mass apoptosis 0.0838443410599309 0.2480790096522 0.722730739893211 0.625 5.5 5 5 abnormal pancreatic beta cell morphology 0.0295176924619528 0.118142011261637 0.722730739893211 0.625 5.5 5 5 abnormal lymphatic vessel morphology 0.049195938825141 0.165595260930363 0.722730739893211 0.625 5.5 5 5 abnormal diaphragm morphology 0.049195938825141 0.165595260930363 0.722730739893211 0.625 5.5 5 5 decreased mast cell number 0.148547394190801 0.355641619874511 0.722730739893211 0.625 5.5 5 5 poor circulation 0.148547394190801 0.355641619874511 0.722730739893211 0.625 5.5 5 5 paternal imprinting 0.148547394190801 0.355641619874511 0.722730739893211 0.625 5.5 5 5 abnormal pulmonary elastic fiber morphology 0.148547394190801 0.355641619874511 0.722730739893211 0.625 5.5 5 5 increased pancreatic beta cell number 0.148547394190801 0.355641619874511 0.722730739893211 0.625 5.5 5 5 bowed tibia 0.148547394190801 0.355641619874511 0.722730739893211 0.625 5.5 5 5 bowed radius 0.148547394190801 0.355641619874511 0.722730739893211 0.625 5.5 5 5 small epididymis 0.148547394190801 0.355641619874511 0.722730739893211 0.625 5.5 5 5 increased thymus weight 0.148547394190801 0.355641619874511 0.722730739893211 0.625 5.5 5 5 decreased circulating prolactin level 0.148547394190801 0.355641619874511 0.722730739893211 0.625 5.5 5 5 abnormal thoracic cage shape 0.148547394190801 0.355641619874511 0.722730739893211 0.625 5.5 5 5 abnormal urinary bladder physiology 0.148547394190801 0.355641619874511 0.722730739893211 0.625 5.5 5 5 decreased adipocyte glucose uptake 0.148547394190801 0.355641619874511 0.722730739893211 0.625 5.5 5 5 abnormal exoccipital bone morphology 0.287214591289763 0.509111703954765 0.722730739893211 0.625 5.5 5 5 absent pre-B cells 0.287214591289763 0.509111703954765 0.722730739893211 0.625 5.5 5 5 abnormal vagus ganglion morphology 0.287214591289763 0.509111703954765 0.722730739893211 0.625 5.5 5 5 abnormal urination 0.287214591289763 0.509111703954765 0.722730739893211 0.625 5.5 5 5 abnormal secondary sex determination 0.287214591289763 0.509111703954765 0.722730739893211 0.625 5.5 5 5 decreased corneal stroma thickness 0.287214591289763 0.509111703954765 0.722730739893211 0.625 5.5 5 5 hypospadia 0.287214591289763 0.509111703954765 0.722730739893211 0.625 5.5 5 5 absent tympanic ring 0.287214591289763 0.509111703954765 0.722730739893211 0.625 5.5 5 5 early eyelid opening 0.287214591289763 0.509111703954765 0.722730739893211 0.625 5.5 5 5 calcified muscle 0.287214591289763 0.509111703954765 0.722730739893211 0.625 5.5 5 5 loss of GABAergic neurons 0.287214591289763 0.509111703954765 0.722730739893211 0.625 5.5 5 5 abnormal perineum morphology 0.287214591289763 0.509111703954765 0.722730739893211 0.625 5.5 5 5 liver failure 0.287214591289763 0.509111703954765 0.722730739893211 0.625 5.5 5 5 increased left ventricle systolic pressure 0.287214591289763 0.509111703954765 0.722730739893211 0.625 5.5 5 5 abnormal gastric gland morphology 0.287214591289763 0.509111703954765 0.722730739893211 0.625 5.5 5 5 long femur 0.287214591289763 0.509111703954765 0.722730739893211 0.625 5.5 5 5 small frontal bone 0.287214591289763 0.509111703954765 0.722730739893211 0.625 5.5 5 5 abnormal optic choroid morphology 0.287214591289763 0.509111703954765 0.722730739893211 0.625 5.5 5 5 increased circulating prolactin level 0.287214591289763 0.509111703954765 0.722730739893211 0.625 5.5 5 5 decreased susceptibility to autoimmune disorder 0.287214591289763 0.509111703954765 0.722730739893211 0.625 5.5 5 5 abnormal ilium morphology 0.287214591289763 0.509111703954765 0.722730739893211 0.625 5.5 5 5 choroidal neovascularization 0.287214591289763 0.509111703954765 0.722730739893211 0.625 5.5 5 5 abnormal epidermal lamellar body morphology 0.287214591289763 0.509111703954765 0.722730739893211 0.625 5.5 5 5 enlarged inguinal lymph nodes 0.287214591289763 0.509111703954765 0.722730739893211 0.625 5.5 5 5 abnormal base-excision repair 0.287214591289763 0.509111703954765 0.722730739893211 0.625 5.5 5 5 skin fibrosis 0.287214591289763 0.509111703954765 0.722730739893211 0.625 5.5 5 5 abnormal lateral plate mesoderm morphology 0.287214591289763 0.509111703954765 0.722730739893211 0.625 5.5 5 5 decreased quadriceps weight 0.287214591289763 0.509111703954765 0.722730739893211 0.625 5.5 5 5 anomalous pulmonary venous connection 0.287214591289763 0.509111703954765 0.722730739893211 0.625 5.5 5 5 myocardial trabeculae hypoplasia 0.287214591289763 0.509111703954765 0.722730739893211 0.625 5.5 5 5 abnormal heart right ventricle pressure 0.287214591289763 0.509111703954765 0.722730739893211 0.625 5.5 5 5 increased airway resistance 0.287214591289763 0.509111703954765 0.722730739893211 0.625 5.5 5 5 abnormal foramen magnum morphology 0.287214591289763 0.509111703954765 0.722730739893211 0.625 5.5 5 5 decreased cranium length 0.287214591289763 0.509111703954765 0.722730739893211 0.625 5.5 5 5 prolonged PQ interval 0.287214591289763 0.509111703954765 0.722730739893211 0.625 5.5 5 5 increased circulating lactate level 0.287214591289763 0.509111703954765 0.722730739893211 0.625 5.5 5 5 increased mammary gland apoptosis 0.287214591289763 0.509111703954765 0.722730739893211 0.625 5.5 5 5 increased circulating glucose level 9.04490432150622e-05 0.00106631277249984 0.721705589907547 0.624113475177305 5.5 5 5 polyuria 0.0034796024940311 0.0220242015366472 0.72085351719219 0.623376623376623 5.5 5 5 hyperkeratosis 0.00556471149452941 0.0321165193564777 0.720635868183376 0.623188405797101 5.5 5 5 abnormal blood homeostasis 0.00045179223448365 0.00402087006539563 0.720194842560253 0.62280701754386 5.5 5 5 abnormal branching of the mammary ductal tree 0.0390541171959588 0.14641615150708 0.71882408724514 0.621621621621622 5.5 5 5 decreased circulating chloride level 0.0390541171959588 0.14641615150708 0.71882408724514 0.621621621621622 5.5 5 5 abnormal pancreatic beta cell physiology 0.0390541171959588 0.14641615150708 0.71882408724514 0.621621621621622 5.5 5 5 abnormal humerus morphology 0.0390541171959588 0.14641615150708 0.71882408724514 0.621621621621622 5.5 5 5 enlarged epididymis 0.0656548696729011 0.208711167171044 0.717746389962913 0.620689655172414 5.5 5 5 increased double-positive T cell number 0.0656548696729011 0.208711167171044 0.717746389962913 0.620689655172414 5.5 5 5 testicular atrophy 0.0189719774747381 0.0855717025719147 0.716948893974066 0.62 5.5 5 5 abnormal CD4-positive, alpha-beta T cell physiology 0.00587472649222441 0.032987318621689 0.716623156175804 0.619718309859155 5.5 5 5 abnormal oocyte morphology 0.0517565047189519 0.173626844893315 0.714228025306232 0.617647058823529 5.5 5 5 abnormal spleen red pulp morphology 0.0517565047189519 0.173626844893315 0.714228025306232 0.617647058823529 5.5 5 5 abnormal eye physiology 0.0122926852128936 0.0590309931796774 0.713094330027968 0.616666666666667 5.5 5 5 increased B cell number 0.000681386328500835 0.00579469569964385 0.711611805433316 0.615384615384615 5.5 5 5 abnormal skin condition 0.0199358189459752 0.0887126111415267 0.711611805433316 0.615384615384615 5.5 5 5 abnormal hair growth 0.0199358189459752 0.0887126111415267 0.711611805433316 0.615384615384615 5.5 5 5 abnormal kidney cortex morphology 0.0878796942671953 0.257783890907604 0.711611805433316 0.615384615384615 5.5 5 5 abnormal Schwann cell morphology 0.0878796942671953 0.257783890907604 0.711611805433316 0.615384615384615 5.5 5 5 abnormal ocular fundus morphology 0.0878796942671953 0.257783890907604 0.711611805433316 0.615384615384615 5.5 5 5 absent trabeculae carneae 0.206502476166709 0.426604375310863 0.711611805433316 0.615384615384615 5.5 5 5 abnormal renal/urinary system morphology 0.206502476166709 0.426604375310863 0.711611805433316 0.615384615384615 5.5 5 5 tight skin 0.206502476166709 0.426604375310863 0.711611805433316 0.615384615384615 5.5 5 5 abnormal grip strength 0.206502476166709 0.426604375310863 0.711611805433316 0.615384615384615 5.5 5 5 increased circulating adrenocorticotropin level 0.206502476166709 0.426604375310863 0.711611805433316 0.615384615384615 5.5 5 5 absent lateral semicircular canal 0.206502476166709 0.426604375310863 0.711611805433316 0.615384615384615 5.5 5 5 decreased alcohol consumption 0.206502476166709 0.426604375310863 0.711611805433316 0.615384615384615 5.5 5 5 abnormal insulin secretion 0.206502476166709 0.426604375310863 0.711611805433316 0.615384615384615 5.5 5 5 small interparietal bone 0.206502476166709 0.426604375310863 0.711611805433316 0.615384615384615 5.5 5 5 decreased luteinizing hormone level 0.206502476166709 0.426604375310863 0.711611805433316 0.615384615384615 5.5 5 5 decreased cardiac stroke volume 0.206502476166709 0.426604375310863 0.711611805433316 0.615384615384615 5.5 5 5 hypertension 0.0326339696824722 0.127713476575588 0.709590180986062 0.613636363636364 5.5 5 5 decreased sensitivity to induced morbidity/mortality 0.0326339696824722 0.127713476575588 0.709590180986062 0.613636363636364 5.5 5 5 absent mature ovarian follicles 0.0687155817985296 0.216504128845906 0.708742402992052 0.612903225806452 5.5 5 5 decreased compact bone thickness 0.0103909300570614 0.0521117712035085 0.707628903537234 0.611940298507463 5.5 5 5 abnormal eye electrophysiology 0.000748679343085473 0.00618717563430271 0.707200988457489 0.611570247933884 5.5 5 5 abnormal uterus morphology 0.0541095951422591 0.179105279995169 0.706670056784473 0.611111111111111 5.5 5 5 abnormal epidermis stratum granulosum morphology 0.0541095951422591 0.179105279995169 0.706670056784473 0.611111111111111 5.5 5 5 lowered ear position 0.154470518545516 0.368051163680048 0.706670056784473 0.611111111111111 5.5 5 5 abnormal heart shape 0.154470518545516 0.368051163680048 0.706670056784473 0.611111111111111 5.5 5 5 delayed kidney development 0.154470518545516 0.368051163680048 0.706670056784473 0.611111111111111 5.5 5 5 abnormal mammary gland morphology 0.154470518545516 0.368051163680048 0.706670056784473 0.611111111111111 5.5 5 5 abnormal white adipose tissue morphology 0.154470518545516 0.368051163680048 0.706670056784473 0.611111111111111 5.5 5 5 abnormal metacarpal bone morphology 0.154470518545516 0.368051163680048 0.706670056784473 0.611111111111111 5.5 5 5 absent allantois 0.154470518545516 0.368051163680048 0.706670056784473 0.611111111111111 5.5 5 5 abnormal redox activity 0.154470518545516 0.368051163680048 0.706670056784473 0.611111111111111 5.5 5 5 abnormal glycogen homeostasis 0.154470518545516 0.368051163680048 0.706670056784473 0.611111111111111 5.5 5 5 decreased fluid intake 0.154470518545516 0.368051163680048 0.706670056784473 0.611111111111111 5.5 5 5 alopecia 0.00280671829549503 0.0187933021804681 0.705993817495684 0.610526315789474 5.5 5 5 increased inflammatory response 0.00280671829549503 0.0187933021804681 0.705993817495684 0.610526315789474 5.5 5 5 lung inflammation 0.000407480694163292 0.00373336363436902 0.705725310719253 0.610294117647059 5.5 5 5 short ulna 0.0428395988931095 0.156068156984988 0.705103160871426 0.609756097560976 5.5 5 5 fragile skeleton 0.118032852234314 0.301809156998612 0.703876894504693 0.608695652173913 5.5 5 5 abnormal blood vessel physiology 0.118032852234314 0.301809156998612 0.703876894504693 0.608695652173913 5.5 5 5 conjunctivitis 0.118032852234314 0.301809156998612 0.703876894504693 0.608695652173913 5.5 5 5 abnormal lens development 0.118032852234314 0.301809156998612 0.703876894504693 0.608695652173913 5.5 5 5 abnormal chondrocyte physiology 0.118032852234314 0.301809156998612 0.703876894504693 0.608695652173913 5.5 5 5 abnormal palatal shelf fusion at midline 0.118032852234314 0.301809156998612 0.703876894504693 0.608695652173913 5.5 5 5 small seminiferous tubules 0.00875796370602364 0.0470020166531474 0.703197476652854 0.608108108108108 5.5 5 5 increased kidney weight 0.0271809648851069 0.109228837078681 0.702891072523594 0.607843137254902 5.5 5 5 abnormal dendritic cell physiology 0.00193597704968911 0.0137986902896895 0.702467261204617 0.607476635514019 5.5 5 5 increased food intake 0.00572720568701102 0.0325080562693618 0.702081290181977 0.607142857142857 5.5 5 5 increased leukocyte cell number 0.000362467668386615 0.00340555222766409 0.70179647018596 0.606896551724138 5.5 5 5 abnormal male meiosis 0.0174519790824325 0.0809921603872215 0.701404259043903 0.60655737704918 5.5 5 5 abnormal skeleton physiology 0.0714721029330934 0.225046653222873 0.700829808381296 0.606060606060606 5.5 5 5 increased circulating free fatty acid level 0.0113021393556381 0.0549334995856956 0.700336266262717 0.605633802816901 5.5 5 5 dermatitis 0.0226063115991676 0.0932557215637305 0.697808990241721 0.603448275862069 5.5 5 5 glomerulosclerosis 0.0226063115991676 0.0932557215637305 0.697808990241721 0.603448275862069 5.5 5 5 abnormal enzyme/coenzyme level 0.0226063115991676 0.0932557215637305 0.697808990241721 0.603448275862069 5.5 5 5 increased urine protein level 0.00947138939367348 0.0503420536682965 0.696786559486788 0.602564102564103 5.5 5 5 increased neutrophil cell number 0.000658482692498287 0.00560950581366263 0.693821510297483 0.6 5.5 5 5 spleen hypoplasia 0.00341733689285453 0.0216576446394284 0.693821510297483 0.6 5.5 5 5 abnormal cell migration 0.0461287845151138 0.156068156984988 0.693821510297483 0.6 5.5 5 5 liver inflammation 0.00183440955720401 0.0132648074812354 0.693821510297483 0.6 5.5 5 5 abnormal digestive system physiology 0.0366812654341592 0.139198547318796 0.693821510297483 0.6 5.5 5 5 abnormal circulating protein level 0.0366812654341592 0.139198547318796 0.693821510297483 0.6 5.5 5 5 increased susceptibility to weight loss 0.0582546085246797 0.189875747266469 0.693821510297483 0.6 5.5 5 5 abnormal microglial cell physiology 0.0945195821898886 0.266486432166307 0.693821510297483 0.6 5.5 5 5 ruffled hair 0.121888590167112 0.309385579633359 0.693821510297483 0.6 5.5 5 5 diaphragmatic hernia 0.121888590167112 0.309385579633359 0.693821510297483 0.6 5.5 5 5 waved hair 0.159170768500431 0.377983089875726 0.693821510297483 0.6 5.5 5 5 increased urine glucose level 0.159170768500431 0.377983089875726 0.693821510297483 0.6 5.5 5 5 decreased skin tensile strength 0.159170768500431 0.377983089875726 0.693821510297483 0.6 5.5 5 5 absent placental labyrinth 0.159170768500431 0.377983089875726 0.693821510297483 0.6 5.5 5 5 abnormal thymocyte activation 0.159170768500431 0.377983089875726 0.693821510297483 0.6 5.5 5 5 abnormal incus morphology 0.159170768500431 0.377983089875726 0.693821510297483 0.6 5.5 5 5 decreased circulating VLDL cholesterol level 0.159170768500431 0.377983089875726 0.693821510297483 0.6 5.5 5 5 decreased salivation 0.211868847696274 0.426604375310863 0.693821510297483 0.6 5.5 5 5 placental labyrinth hypoplasia 0.211868847696274 0.426604375310863 0.693821510297483 0.6 5.5 5 5 abnormal respiratory system morphology 0.211868847696274 0.426604375310863 0.693821510297483 0.6 5.5 5 5 abnormal cricoid cartilage morphology 0.211868847696274 0.426604375310863 0.693821510297483 0.6 5.5 5 5 altered righting response 0.211868847696274 0.426604375310863 0.693821510297483 0.6 5.5 5 5 abnormal coronary vessel morphology 0.211868847696274 0.426604375310863 0.693821510297483 0.6 5.5 5 5 abnormal otic capsule morphology 0.291522382336445 0.509111703954765 0.693821510297483 0.6 5.5 5 5 abnormal auchene hair morphology 0.291522382336445 0.509111703954765 0.693821510297483 0.6 5.5 5 5 jaundice 0.291522382336445 0.509111703954765 0.693821510297483 0.6 5.5 5 5 abnormal epidermis suprabasal layer morphology 0.291522382336445 0.509111703954765 0.693821510297483 0.6 5.5 5 5 abnormal neuron specification 0.291522382336445 0.509111703954765 0.693821510297483 0.6 5.5 5 5 rickets 0.291522382336445 0.509111703954765 0.693821510297483 0.6 5.5 5 5 abnormal glial cell physiology 0.291522382336445 0.509111703954765 0.693821510297483 0.6 5.5 5 5 absent CD4-positive, alpha beta T cells 0.291522382336445 0.509111703954765 0.693821510297483 0.6 5.5 5 5 abnormal hindlimb zeugopod morphology 0.291522382336445 0.509111703954765 0.693821510297483 0.6 5.5 5 5 absent pharyngeal arches 0.291522382336445 0.509111703954765 0.693821510297483 0.6 5.5 5 5 abnormal ear physiology 0.291522382336445 0.509111703954765 0.693821510297483 0.6 5.5 5 5 abnormal placental transport 0.291522382336445 0.509111703954765 0.693821510297483 0.6 5.5 5 5 ascites 0.291522382336445 0.509111703954765 0.693821510297483 0.6 5.5 5 5 increased platelet aggregation 0.291522382336445 0.509111703954765 0.693821510297483 0.6 5.5 5 5 increased serotonin level 0.291522382336445 0.509111703954765 0.693821510297483 0.6 5.5 5 5 abnormal retinal blood vessel pattern 0.291522382336445 0.509111703954765 0.693821510297483 0.6 5.5 5 5 umbilical hernia 0.291522382336445 0.509111703954765 0.693821510297483 0.6 5.5 5 5 abnormal heart and great artery attachment 0.291522382336445 0.509111703954765 0.693821510297483 0.6 5.5 5 5 common ventricle 0.291522382336445 0.509111703954765 0.693821510297483 0.6 5.5 5 5 abnormal left subclavian artery morphology 0.291522382336445 0.509111703954765 0.693821510297483 0.6 5.5 5 5 thick aortic valve 0.291522382336445 0.509111703954765 0.693821510297483 0.6 5.5 5 5 sinus bradycardia 0.291522382336445 0.509111703954765 0.693821510297483 0.6 5.5 5 5 abnormal adaptive thermogenesis 0.291522382336445 0.509111703954765 0.693821510297483 0.6 5.5 5 5 abnormal circadian temperature homeostasis 0.291522382336445 0.509111703954765 0.693821510297483 0.6 5.5 5 5 decreased macrophage apoptosis 0.291522382336445 0.509111703954765 0.693821510297483 0.6 5.5 5 5 abnormal cytokine secretion 0.000575253365036237 0.004977192158357 0.690817953975849 0.597402597402597 5.5 5 5 abnormal trabecular bone morphology 0.00241291375194619 0.0164441724875785 0.689934555057721 0.596638655462185 5.5 5 5 decreased susceptibility to induced arthritis 0.0302366546423038 0.120534741062068 0.689764074564749 0.596491228070175 5.5 5 5 abnormal vibrissa morphology 0.060074856245835 0.193070032185419 0.688314990374487 0.595238095238095 5.5 5 5 increased white adipose tissue amount 0.0761909627968334 0.234851325845258 0.687570866060569 0.594594594594595 5.5 5 5 abnormal food intake 0.0200335499071668 0.0890678380591197 0.68711792082601 0.594202898550725 5.5 5 5 rectal prolapse 0.125150499298155 0.317503178994553 0.685255812639489 0.592592592592593 5.5 5 5 abnormal skeleton development 0.0133784889505888 0.0639365826409023 0.685255812639489 0.592592592592593 5.5 5 5 short femur 0.0111133197832616 0.0549334995856956 0.683309063171764 0.590909090909091 5.5 5 5 decreased macrophage cell number 0.0617441394602577 0.196782251002423 0.683309063171764 0.590909090909091 5.5 5 5 increased activated T cell number 0.162914416341219 0.385584786535473 0.683309063171764 0.590909090909091 5.5 5 5 abnormal circulating lipid level 0.162914416341219 0.385584786535473 0.683309063171764 0.590909090909091 5.5 5 5 cleft upper lip 0.162914416341219 0.385584786535473 0.683309063171764 0.590909090909091 5.5 5 5 decreased circulating estradiol level 0.162914416341219 0.385584786535473 0.683309063171764 0.590909090909091 5.5 5 5 abnormal temporal bone morphology 0.162914416341219 0.385584786535473 0.683309063171764 0.590909090909091 5.5 5 5 rough coat 0.162914416341219 0.385584786535473 0.683309063171764 0.590909090909091 5.5 5 5 impaired humoral immune response 0.162914416341219 0.385584786535473 0.683309063171764 0.590909090909091 5.5 5 5 decreased neutrophil cell number 0.00411176984572193 0.0255063029706566 0.681961313540261 0.58974358974359 5.5 5 5 increased autoantibody level 0.078204529704492 0.236147615938652 0.681961313540261 0.58974358974359 5.5 5 5 impaired macrophage chemotaxis 0.078204529704492 0.236147615938652 0.681961313540261 0.58974358974359 5.5 5 5 abnormal retinal photoreceptor morphology 0.0996372432390097 0.266486432166307 0.680217166958317 0.588235294117647 5.5 5 5 decreased pancreatic beta cell number 0.0996372432390097 0.266486432166307 0.680217166958317 0.588235294117647 5.5 5 5 increased width of hypertrophic chondrocyte zone 0.0996372432390097 0.266486432166307 0.680217166958317 0.588235294117647 5.5 5 5 hydroureter 0.215660302292828 0.426604375310863 0.680217166958317 0.588235294117647 5.5 5 5 enlarged sebaceous gland 0.215660302292828 0.426604375310863 0.680217166958317 0.588235294117647 5.5 5 5 abnormal heart rate 0.215660302292828 0.426604375310863 0.680217166958317 0.588235294117647 5.5 5 5 aminoaciduria 0.215660302292828 0.426604375310863 0.680217166958317 0.588235294117647 5.5 5 5 increased regulatory T cell number 0.215660302292828 0.426604375310863 0.680217166958317 0.588235294117647 5.5 5 5 abnormal circulating chemokine level 0.215660302292828 0.426604375310863 0.680217166958317 0.588235294117647 5.5 5 5 common atrium 0.215660302292828 0.426604375310863 0.680217166958317 0.588235294117647 5.5 5 5 abnormal survival 0.215660302292828 0.426604375310863 0.680217166958317 0.588235294117647 5.5 5 5 delayed heart development 0.215660302292828 0.426604375310863 0.680217166958317 0.588235294117647 5.5 5 5 abnormal cell cytoskeleton morphology 0.215660302292828 0.426604375310863 0.680217166958317 0.588235294117647 5.5 5 5 decreased T cell proliferation 0.00159489761999959 0.0117202594675007 0.679757560764426 0.587837837837838 5.5 5 5 abnormal middle ear morphology 0.127911912674065 0.324013118917246 0.677871590520529 0.586206896551724 5.5 5 5 polychromatophilia 0.127911912674065 0.324013118917246 0.677871590520529 0.586206896551724 5.5 5 5 increased retinal apoptosis 0.127911912674065 0.324013118917246 0.677871590520529 0.586206896551724 5.5 5 5 scaly skin 0.0800169750633666 0.238516747118184 0.676899034436569 0.585365853658537 5.5 5 5 arrested B cell differentiation 0.0800169750633666 0.238516747118184 0.676899034436569 0.585365853658537 5.5 5 5 abnormal long bone epiphyseal plate morphology 0.0419758970696251 0.153101237479021 0.674548690566997 0.583333333333333 5.5 5 5 abnormal systemic arterial blood pressure 0.101738223942349 0.266486432166307 0.674548690566997 0.583333333333333 5.5 5 5 abnormal malleus morphology 0.165896767878448 0.392270161689771 0.674548690566997 0.583333333333333 5.5 5 5 ocular hypertelorism 0.165896767878448 0.392270161689771 0.674548690566997 0.583333333333333 5.5 5 5 increased papilloma incidence 0.293391409943934 0.509111703954765 0.674548690566997 0.583333333333333 5.5 5 5 abnormal tracheal ciliated epithelium morphology 0.293391409943934 0.509111703954765 0.674548690566997 0.583333333333333 5.5 5 5 small thyroid gland 0.293391409943934 0.509111703954765 0.674548690566997 0.583333333333333 5.5 5 5 decreased circulating ketone body level 0.293391409943934 0.509111703954765 0.674548690566997 0.583333333333333 5.5 5 5 pale placenta 0.293391409943934 0.509111703954765 0.674548690566997 0.583333333333333 5.5 5 5 abnormal B cell proliferation 0.293391409943934 0.509111703954765 0.674548690566997 0.583333333333333 5.5 5 5 abnormal amacrine cell morphology 0.293391409943934 0.509111703954765 0.674548690566997 0.583333333333333 5.5 5 5 abnormal patella morphology 0.293391409943934 0.509111703954765 0.674548690566997 0.583333333333333 5.5 5 5 hemoperitoneum 0.293391409943934 0.509111703954765 0.674548690566997 0.583333333333333 5.5 5 5 abnormal thymus corticomedullary boundary morphology 0.293391409943934 0.509111703954765 0.674548690566997 0.583333333333333 5.5 5 5 hydrometra 0.293391409943934 0.509111703954765 0.674548690566997 0.583333333333333 5.5 5 5 impaired behavioral response to cocaine 0.293391409943934 0.509111703954765 0.674548690566997 0.583333333333333 5.5 5 5 abnormal aorta elastic tissue morphology 0.293391409943934 0.509111703954765 0.674548690566997 0.583333333333333 5.5 5 5 increased fibrosarcoma incidence 0.293391409943934 0.509111703954765 0.674548690566997 0.583333333333333 5.5 5 5 abnormal respiratory motile cilium morphology 0.293391409943934 0.509111703954765 0.674548690566997 0.583333333333333 5.5 5 5 abnormal colon goblet cell morphology 0.293391409943934 0.509111703954765 0.674548690566997 0.583333333333333 5.5 5 5 kidney inflammation 0.0659580351868548 0.20954101216769 0.6706941266209 0.58 5.5 5 5 decreased threshold for auditory brainstem response 0.103581263160387 0.270507498279752 0.66947689590108 0.578947368421053 5.5 5 5 enlarged adrenal glands 0.218310488024939 0.430306924692579 0.66947689590108 0.578947368421053 5.5 5 5 shiny skin 0.218310488024939 0.430306924692579 0.66947689590108 0.578947368421053 5.5 5 5 short vibrissae 0.218310488024939 0.430306924692579 0.66947689590108 0.578947368421053 5.5 5 5 decreased tumor incidence 0.218310488024939 0.430306924692579 0.66947689590108 0.578947368421053 5.5 5 5 decreased liver regeneration 0.218310488024939 0.430306924692579 0.66947689590108 0.578947368421053 5.5 5 5 decreased fertilization frequency 0.218310488024939 0.430306924692579 0.66947689590108 0.578947368421053 5.5 5 5 increased liver cholesterol level 0.218310488024939 0.430306924692579 0.66947689590108 0.578947368421053 5.5 5 5 decreased susceptibility to weight gain 0.218310488024939 0.430306924692579 0.66947689590108 0.578947368421053 5.5 5 5 thin interventricular septum 0.218310488024939 0.430306924692579 0.66947689590108 0.578947368421053 5.5 5 5 decreased osteoclast cell number 0.0831125199115065 0.247595680574698 0.668124417323502 0.577777777777778 5.5 5 5 abnormal tectorial membrane morphology 0.168264357303363 0.395068817115734 0.667136067593733 0.576923076923077 5.5 5 5 decreased IgG level 0.0110117559674751 0.0549334995856956 0.666735385270854 0.576576576576577 5.5 5 5 increased B cell proliferation 0.0545000445053919 0.179680398551574 0.666382241528656 0.576271186440678 5.5 5 5 abnormal epidermis stratum basale morphology 0.132220831381372 0.331051150539672 0.665788317962231 0.575757575757576 5.5 5 5 abnormal T cell subpopulation ratio 0.132220831381372 0.331051150539672 0.665788317962231 0.575757575757576 5.5 5 5 diarrhea 0.132220831381372 0.331051150539672 0.665788317962231 0.575757575757576 5.5 5 5 decreased sensitivity to xenobiotic induced morbidity/mortality 0.132220831381372 0.331051150539672 0.665788317962231 0.575757575757576 5.5 5 5 abnormal NK cell physiology 0.0553736555092663 0.182439692820265 0.6634905153118 0.573770491803279 5.5 5 5 abnormal response/metabolism to endogenous compounds 0.0302821626710791 0.120619503033322 0.66279697121914 0.573170731707317 5.5 5 5 abnormal stria vascularis morphology 0.170129292085206 0.395068817115734 0.660782390759508 0.571428571428571 5.5 5 5 decreased circulating progesterone level 0.170129292085206 0.395068817115734 0.660782390759508 0.571428571428571 5.5 5 5 abnormal kidney blood vessel morphology 0.293800945136509 0.509111703954765 0.660782390759508 0.571428571428571 5.5 5 5 extended life span 0.293800945136509 0.509111703954765 0.660782390759508 0.571428571428571 5.5 5 5 absent visceral yolk sac blood islands 0.293800945136509 0.509111703954765 0.660782390759508 0.571428571428571 5.5 5 5 abnormal olfactory system physiology 0.293800945136509 0.509111703954765 0.660782390759508 0.571428571428571 5.5 5 5 decreased coping response 0.293800945136509 0.509111703954765 0.660782390759508 0.571428571428571 5.5 5 5 decreased vascular permeability 0.293800945136509 0.509111703954765 0.660782390759508 0.571428571428571 5.5 5 5 abnormal uterus development 0.293800945136509 0.509111703954765 0.660782390759508 0.571428571428571 5.5 5 5 abnormal squamosal bone morphology 0.293800945136509 0.509111703954765 0.660782390759508 0.571428571428571 5.5 5 5 abnormal positive T cell selection 0.293800945136509 0.509111703954765 0.660782390759508 0.571428571428571 5.5 5 5 increased B-1 B cell number 0.293800945136509 0.509111703954765 0.660782390759508 0.571428571428571 5.5 5 5 premature hair loss 0.293800945136509 0.509111703954765 0.660782390759508 0.571428571428571 5.5 5 5 decreased cornea thickness 0.293800945136509 0.509111703954765 0.660782390759508 0.571428571428571 5.5 5 5 abnormal cytotoxic T cell physiology 0.106606466820076 0.278261895293744 0.660782390759507 0.571428571428571 5.5 5 5 increased incidence of induced tumors 0.220109859964223 0.432824724633206 0.660782390759507 0.571428571428571 5.5 5 5 hypoalgesia 0.220109859964223 0.432824724633206 0.660782390759507 0.571428571428571 5.5 5 5 abnormal stapes morphology 0.220109859964223 0.432824724633206 0.660782390759507 0.571428571428571 5.5 5 5 increased keratinocyte proliferation 0.220109859964223 0.432824724633206 0.660782390759507 0.571428571428571 5.5 5 5 vascular ring 0.220109859964223 0.432824724633206 0.660782390759507 0.571428571428571 5.5 5 5 abnormal response to infection 0.0379893477522054 0.143723958226024 0.658691307244446 0.569620253164557 5.5 5 5 increased susceptibility to bacterial infection induced morbidity/mortality 0.0464293933014972 0.156494736907147 0.658488007458259 0.569444444444444 5.5 5 5 increased insulin secretion 0.135269004195838 0.338512724282844 0.656317644875997 0.567567567567568 5.5 5 5 abnormal femur morphology 0.0576140092192592 0.189569904673158 0.655851178888168 0.567164179104478 5.5 5 5 maternal effect 0.0576140092192592 0.189569904673158 0.655851178888168 0.567164179104478 5.5 5 5 increased metastatic potential 0.171578806384142 0.395187297111622 0.655275870836512 0.566666666666667 5.5 5 5 abnormal circulating insulin level 0.221260449680195 0.434229087636676 0.653599973468643 0.565217391304348 5.5 5 5 abnormal postnatal growth 0.221260449680195 0.434229087636676 0.653599973468643 0.565217391304348 5.5 5 5 decreased epididymis weight 0.221260449680195 0.434229087636676 0.653599973468643 0.565217391304348 5.5 5 5 abnormal ulna morphology 0.221260449680195 0.434229087636676 0.653599973468643 0.565217391304348 5.5 5 5 abnormal epidermal layer morphology 0.058246616554951 0.189875747266469 0.653599973468643 0.565217391304348 5.5 5 5 acanthosis 0.13642174175037 0.341225824639562 0.652310821647206 0.564102564102564 5.5 5 5 abnormal intestinal epithelium morphology 0.109823244571313 0.285013375974066 0.65045766590389 0.5625 5.5 5 5 abnormal lymph node morphology 0.109823244571313 0.285013375974066 0.65045766590389 0.5625 5.5 5 5 increased dopamine level 0.172681793289349 0.397359815732891 0.65045766590389 0.5625 5.5 5 5 increased fatty acid level 0.172681793289349 0.397359815732891 0.65045766590389 0.5625 5.5 5 5 abnormal bone marrow cell number 0.293282145060454 0.509111703954765 0.65045766590389 0.5625 5.5 5 5 delayed hair appearance 0.293282145060454 0.509111703954765 0.65045766590389 0.5625 5.5 5 5 abnormal pituitary gland morphology 0.293282145060454 0.509111703954765 0.65045766590389 0.5625 5.5 5 5 disorganized retinal layers 0.293282145060454 0.509111703954765 0.65045766590389 0.5625 5.5 5 5 abnormal intestinal absorption 0.293282145060454 0.509111703954765 0.65045766590389 0.5625 5.5 5 5 large intestinal inflammation 0.293282145060454 0.509111703954765 0.65045766590389 0.5625 5.5 5 5 abnormal wound healing 0.293282145060454 0.509111703954765 0.65045766590389 0.5625 5.5 5 5 dilated respiratory conducting tubes 0.293282145060454 0.509111703954765 0.65045766590389 0.5625 5.5 5 5 abnormal bone remodeling 0.173493376361699 0.399042786592443 0.646206308610401 0.558823529411765 5.5 5 5 decreased IgA level 0.111283727539941 0.288502628718711 0.644898198673942 0.557692307692308 5.5 5 5 decreased body temperature 0.111283727539941 0.288502628718711 0.644898198673942 0.557692307692308 5.5 5 5 impaired fertilization 0.0738959780483261 0.228242745662068 0.64426283099052 0.557142857142857 5.5 5 5 wrinkled skin 0.222156679809874 0.435301095728289 0.642427324349521 0.555555555555556 5.5 5 5 cryptorchism 0.222156679809874 0.435301095728289 0.642427324349521 0.555555555555556 5.5 5 5 abnormal stomach glandular epithelium morphology 0.29214753197697 0.509111703954765 0.642427324349521 0.555555555555556 5.5 5 5 abnormal radius morphology 0.29214753197697 0.509111703954765 0.642427324349521 0.555555555555556 5.5 5 5 decreased heart rate variability 0.29214753197697 0.509111703954765 0.642427324349521 0.555555555555556 5.5 5 5 abnormal sperm axoneme morphology 0.29214753197697 0.509111703954765 0.642427324349521 0.555555555555556 5.5 5 5 renal tubular acidosis 0.411384855906617 0.59769918495045 0.642427324349521 0.555555555555556 5.5 5 5 synostosis 0.411384855906617 0.59769918495045 0.642427324349521 0.555555555555556 5.5 5 5 absent parathyroid glands 0.411384855906617 0.59769918495045 0.642427324349521 0.555555555555556 5.5 5 5 small geniculate ganglion 0.411384855906617 0.59769918495045 0.642427324349521 0.555555555555556 5.5 5 5 multifocal hepatic necrosis 0.411384855906617 0.59769918495045 0.642427324349521 0.555555555555556 5.5 5 5 abnormal germ cell morphology 0.411384855906617 0.59769918495045 0.642427324349521 0.555555555555556 5.5 5 5 abnormal laryngeal cartilage morphology 0.411384855906617 0.59769918495045 0.642427324349521 0.555555555555556 5.5 5 5 long gestation period 0.411384855906617 0.59769918495045 0.642427324349521 0.555555555555556 5.5 5 5 abnormal abdominal wall morphology 0.411384855906617 0.59769918495045 0.642427324349521 0.555555555555556 5.5 5 5 abnormal ovary physiology 0.411384855906617 0.59769918495045 0.642427324349521 0.555555555555556 5.5 5 5 impaired febrile response 0.411384855906617 0.59769918495045 0.642427324349521 0.555555555555556 5.5 5 5 abnormal stria vascularis vasculature morphology 0.411384855906617 0.59769918495045 0.642427324349521 0.555555555555556 5.5 5 5 abnormal gallbladder physiology 0.411384855906617 0.59769918495045 0.642427324349521 0.555555555555556 5.5 5 5 absent adrenal gland 0.411384855906617 0.59769918495045 0.642427324349521 0.555555555555556 5.5 5 5 decreased pulmonary ventilation 0.411384855906617 0.59769918495045 0.642427324349521 0.555555555555556 5.5 5 5 abnormal retinal development 0.411384855906617 0.59769918495045 0.642427324349521 0.555555555555556 5.5 5 5 multiflagellated sperm 0.411384855906617 0.59769918495045 0.642427324349521 0.555555555555556 5.5 5 5 eye opacity 0.411384855906617 0.59769918495045 0.642427324349521 0.555555555555556 5.5 5 5 abnormal hyoid bone lesser horn morphology 0.411384855906617 0.59769918495045 0.642427324349521 0.555555555555556 5.5 5 5 shortened ST segment 0.411384855906617 0.59769918495045 0.642427324349521 0.555555555555556 5.5 5 5 adipose tissue inflammation 0.411384855906617 0.59769918495045 0.642427324349521 0.555555555555556 5.5 5 5 abnormal T cell activation 0.0747067865169672 0.230419257856114 0.640691034283712 0.554054054054054 5.5 5 5 hepatic necrosis 0.139204616100965 0.347836747916775 0.639693591054417 0.553191489361702 5.5 5 5 abnormal T-helper 1 physiology 0.139204616100965 0.347836747916775 0.639693591054417 0.553191489361702 5.5 5 5 abnormal Peyer's patch T cell area morphology 0.290592367443781 0.509111703954765 0.636003051106026 0.55 5.5 5 5 abnormal physiological neovascularization 0.290592367443781 0.509111703954765 0.636003051106026 0.55 5.5 5 5 abnormal heart right ventricle morphology 0.290592367443781 0.509111703954765 0.636003051106026 0.55 5.5 5 5 abnormal cervical vertebrae morphology 0.139772593579384 0.349080649125218 0.634869355827762 0.549019607843137 5.5 5 5 autoimmune response 0.221765973566416 0.434878091640883 0.634137939519205 0.548387096774194 5.5 5 5 abnormal CD8-positive, alpha beta T cell morphology 0.221765973566416 0.434878091640883 0.634137939519205 0.548387096774194 5.5 5 5 parakeratosis 0.288744392311829 0.509111703954765 0.630746827543166 0.545454545454545 5.5 5 5 abnormal retinal layer morphology 0.288744392311829 0.509111703954765 0.630746827543166 0.545454545454545 5.5 5 5 failure of palatal shelf elevation 0.288744392311829 0.509111703954765 0.630746827543166 0.545454545454545 5.5 5 5 abnormal ear position 0.402690461704145 0.59769918495045 0.630746827543166 0.545454545454545 5.5 5 5 abnormal hemoglobin 0.402690461704145 0.59769918495045 0.630746827543166 0.545454545454545 5.5 5 5 vasculitis 0.402690461704145 0.59769918495045 0.630746827543166 0.545454545454545 5.5 5 5 variable body spotting 0.402690461704145 0.59769918495045 0.630746827543166 0.545454545454545 5.5 5 5 allodynia 0.402690461704145 0.59769918495045 0.630746827543166 0.545454545454545 5.5 5 5 abnormal frequency of paradoxical sleep 0.402690461704145 0.59769918495045 0.630746827543166 0.545454545454545 5.5 5 5 pulmonary hypertension 0.402690461704145 0.59769918495045 0.630746827543166 0.545454545454545 5.5 5 5 abnormal hair medulla 0.402690461704145 0.59769918495045 0.630746827543166 0.545454545454545 5.5 5 5 decreased palatine bone horizontal plate size 0.402690461704145 0.59769918495045 0.630746827543166 0.545454545454545 5.5 5 5 shortened PR interval 0.402690461704145 0.59769918495045 0.630746827543166 0.545454545454545 5.5 5 5 abnormal extraembryonic ectoderm morphology 0.402690461704145 0.59769918495045 0.630746827543166 0.545454545454545 5.5 5 5 absent vibrissae 0.221234947578919 0.434229087636676 0.630746827543166 0.545454545454545 5.5 5 5 abnormal immune system morphology 0.174260365476917 0.400436636604001 0.628461512950618 0.543478260869565 5.5 5 5 abnormal lymphocyte physiology 0.174260365476917 0.400436636604001 0.628461512950618 0.543478260869565 5.5 5 5 abnormal foregut morphology 0.286690255445897 0.509111703954765 0.626366641240783 0.541666666666667 5.5 5 5 increased vascular permeability 0.21873545060455 0.430973808616885 0.622660329754151 0.538461538461538 5.5 5 5 pulmonary edema 0.284490464207913 0.509111703954765 0.622660329754151 0.538461538461538 5.5 5 5 absent myocardial trabeculae 0.39476183268403 0.59769918495045 0.622660329754151 0.538461538461538 5.5 5 5 pup cannibalization 0.39476183268403 0.59769918495045 0.622660329754151 0.538461538461538 5.5 5 5 abnormal intercostal muscle morphology 0.39476183268403 0.59769918495045 0.622660329754151 0.538461538461538 5.5 5 5 abnormal otolith morphology 0.39476183268403 0.59769918495045 0.622660329754151 0.538461538461538 5.5 5 5 abnormal GABAergic neuron morphology 0.39476183268403 0.59769918495045 0.622660329754151 0.538461538461538 5.5 5 5 abnormal exocrine pancreas morphology 0.39476183268403 0.59769918495045 0.622660329754151 0.538461538461538 5.5 5 5 increased circulating ammonia level 0.39476183268403 0.59769918495045 0.622660329754151 0.538461538461538 5.5 5 5 increased renin activity 0.39476183268403 0.59769918495045 0.622660329754151 0.538461538461538 5.5 5 5 increased circulating luteinizing hormone level 0.282188281030645 0.50847037237503 0.619483491337038 0.535714285714286 5.5 5 5 abnormal respiration 0.282188281030645 0.50847037237503 0.619483491337038 0.535714285714286 5.5 5 5 abnormal spleen germinal center morphology 0.282188281030645 0.50847037237503 0.619483491337038 0.535714285714286 5.5 5 5 decreased inflammatory response 0.112341003607536 0.291091923410152 0.619483491337038 0.535714285714286 5.5 5 5 gastrointestinal hemorrhage 0.279815243421303 0.504742870203401 0.61673023137554 0.533333333333333 5.5 5 5 abnormal fat pad morphology 0.279815243421303 0.504742870203401 0.61673023137554 0.533333333333333 5.5 5 5 vagina atresia 0.387437627925349 0.59769918495045 0.61673023137554 0.533333333333333 5.5 5 5 arthritis 0.387437627925349 0.59769918495045 0.61673023137554 0.533333333333333 5.5 5 5 greasy coat 0.387437627925349 0.59769918495045 0.61673023137554 0.533333333333333 5.5 5 5 lactation failure 0.387437627925349 0.59769918495045 0.61673023137554 0.533333333333333 5.5 5 5 decreased trabecular bone mass 0.387437627925349 0.59769918495045 0.61673023137554 0.533333333333333 5.5 5 5 increased sensitivity to induced morbidity/mortality 0.0357692920453642 0.13667605831466 0.615892282691606 0.532608695652174 5.5 5 5 polydipsia 0.27739471121376 0.502626219992349 0.61432112890923 0.53125 5.5 5 5 abnormal epidermis stratum corneum morphology 0.212796658615528 0.426604375310863 0.6135836485624 0.530612244897959 5.5 5 5 decreased susceptibility to injury 0.167171598104602 0.39490916456334 0.612195450262485 0.529411764705882 5.5 5 5 decreased osteoblast cell number 0.274944215198292 0.502626219992349 0.612195450262485 0.529411764705882 5.5 5 5 decreased cytotoxic T cell cytolysis 0.274944215198292 0.502626219992349 0.612195450262485 0.529411764705882 5.5 5 5 abnormal skin physiology 0.274944215198292 0.502626219992349 0.612195450262485 0.529411764705882 5.5 5 5 pancytopenia 0.380606718174033 0.59769918495045 0.612195450262485 0.529411764705882 5.5 5 5 abnormal tendon morphology 0.380606718174033 0.59769918495045 0.612195450262485 0.529411764705882 5.5 5 5 abnormal thrombosis 0.211459142613431 0.426604375310863 0.612195450262485 0.529411764705882 5.5 5 5 dehydration 0.166290848652511 0.393015188620543 0.611223711452544 0.528571428571429 5.5 5 5 abnormal triglyceride level 0.374188691923671 0.59769918495045 0.608615359910073 0.526315789473684 5.5 5 5 flaky skin 0.374188691923671 0.59769918495045 0.608615359910073 0.526315789473684 5.5 5 5 osteoarthritis 0.374188691923671 0.59769918495045 0.608615359910073 0.526315789473684 5.5 5 5 abnormal carpal bone morphology 0.362363238819066 0.59769918495045 0.603323052432594 0.521739130434783 5.5 5 5 hypotension 0.362363238819066 0.59769918495045 0.603323052432594 0.521739130434783 5.5 5 5 pancreas inflammation 0.362363238819066 0.59769918495045 0.603323052432594 0.521739130434783 5.5 5 5 abnormal hepatocyte physiology 0.362363238819066 0.59769918495045 0.603323052432594 0.521739130434783 5.5 5 5 abnormal kidney physiology 0.257757736847753 0.482412495948122 0.602275616577676 0.520833333333333 5.5 5 5 abnormal hair shaft morphology 0.257757736847753 0.482412495948122 0.602275616577676 0.520833333333333 5.5 5 5 increased pre-B cell number 0.356871924981367 0.59769918495045 0.601311975591152 0.52 5.5 5 5 abnormal leukocyte migration 0.252984644360505 0.482412495948122 0.60042246083436 0.519230769230769 5.5 5 5 increased susceptibility to injury 0.252984644360505 0.482412495948122 0.60042246083436 0.519230769230769 5.5 5 5 decreased granulocyte number 0.346580213919033 0.59769918495045 0.598121991635761 0.517241379310345 5.5 5 5 stomach inflammation 0.346580213919033 0.59769918495045 0.598121991635761 0.517241379310345 5.5 5 5 abnormal middle ear ossicle morphology 0.337064460075779 0.583268065696347 0.595705337124101 0.515151515151515 5.5 5 5 abnormal inflammatory response 0.230622844522992 0.451534298111722 0.594245275023307 0.513888888888889 5.5 5 5 impaired macrophage phagocytosis 0.315892990223364 0.546822416966332 0.591630745214908 0.511627906976744 5.5 5 5 decreased urine osmolality 0.304592193339655 0.527443843322235 0.589984277463846 0.510204081632653 5.5 5 5 abnormal T-helper 2 physiology 0.294122397520003 0.509491270077303 0.588697039040288 0.509090909090909 5.5 5 5 abnormal humoral immune response 0.227543584419505 0.445680839561825 0.583691111837565 0.504761904761905 5.5 5 5 abnormal urine homeostasis 0.270227367137993 0.500887165242741 0.578184591914569 0.5 5.5 5 5 abnormal crypts of Lieberkuhn morphology 0.406074217985938 0.59769918495045 0.578184591914569 0.5 5.5 5 5 curly vibrissae 0.438036222192235 0.59769918495045 0.578184591914569 0.5 5.5 5 5 impaired wound healing 0.392633525660175 0.59769918495045 0.578184591914569 0.5 5.5 5 5 decreased ovulation rate 0.438036222192235 0.59769918495045 0.578184591914569 0.5 5.5 5 5 decreased regulatory T cell number 0.399184704953266 0.59769918495045 0.578184591914569 0.5 5.5 5 5 decreased susceptibility to parasitic infection 0.406074217985938 0.59769918495045 0.578184591914569 0.5 5.5 5 5 thick dermal layer 0.469065904371095 0.604247248639616 0.578184591914569 0.5 5.5 5 5 abnormal macrophage chemotaxis 0.469065904371095 0.604247248639616 0.578184591914569 0.5 5.5 5 5 abnormal mouth morphology 0.481593110790244 0.619102254827252 0.578184591914569 0.5 5.5 5 5 decreased aggression towards mice 0.481593110790244 0.619102254827252 0.578184591914569 0.5 5.5 5 5 abnormal level of surface class II molecules 0.481593110790244 0.619102254827252 0.578184591914569 0.5 5.5 5 5 sepsis 0.481593110790244 0.619102254827252 0.578184591914569 0.5 5.5 5 5 increased circulating estradiol level 0.481593110790244 0.619102254827252 0.578184591914569 0.5 5.5 5 5 abnormal Langerhans cell physiology 0.481593110790244 0.619102254827252 0.578184591914569 0.5 5.5 5 5 abnormal vasoconstriction 0.495722720231552 0.636608294566849 0.578184591914569 0.5 5.5 5 5 abnormal zigzag hair morphology 0.495722720231552 0.636608294566849 0.578184591914569 0.5 5.5 5 5 increased lung compliance 0.495722720231552 0.636608294566849 0.578184591914569 0.5 5.5 5 5 abnormal respiratory motile cilium physiology 0.495722720231552 0.636608294566849 0.578184591914569 0.5 5.5 5 5 abnormal mineral level 0.511989513464356 0.65563650694599 0.578184591914569 0.5 5.5 5 5 abnormal esophagus morphology 0.511989513464356 0.65563650694599 0.578184591914569 0.5 5.5 5 5 decreased digestive secretion 0.511989513464356 0.65563650694599 0.578184591914569 0.5 5.5 5 5 ear inflammation 0.511989513464356 0.65563650694599 0.578184591914569 0.5 5.5 5 5 absent tail 0.511989513464356 0.65563650694599 0.578184591914569 0.5 5.5 5 5 abnormal nucleotide metabolism 0.511989513464356 0.65563650694599 0.578184591914569 0.5 5.5 5 5 increased hepatocyte proliferation 0.511989513464356 0.65563650694599 0.578184591914569 0.5 5.5 5 5 abnormal fatty acid level 0.511989513464356 0.65563650694599 0.578184591914569 0.5 5.5 5 5 decreased keratinocyte proliferation 0.511989513464356 0.65563650694599 0.578184591914569 0.5 5.5 5 5 decreased oligodendrocyte number 0.511989513464356 0.65563650694599 0.578184591914569 0.5 5.5 5 5 brain inflammation 0.457785016403559 0.59769918495045 0.578184591914569 0.5 5.5 5 5 abnormal male reproductive system physiology 0.457785016403559 0.59769918495045 0.578184591914569 0.5 5.5 5 5 nuclear cataracts 0.457785016403559 0.59769918495045 0.578184591914569 0.5 5.5 5 5 abnormal lateral semicircular canal morphology 0.531247329476789 0.676986543070448 0.578184591914569 0.5 5.5 5 5 absent maxillary shelf 0.531247329476789 0.676986543070448 0.578184591914569 0.5 5.5 5 5 absent palatine bone horizontal plate 0.531247329476789 0.676986543070448 0.578184591914569 0.5 5.5 5 5 increased cranium width 0.531247329476789 0.676986543070448 0.578184591914569 0.5 5.5 5 5 kidney hemorrhage 0.531247329476789 0.676986543070448 0.578184591914569 0.5 5.5 5 5 abnormal respiratory mechanics 0.531247329476789 0.676986543070448 0.578184591914569 0.5 5.5 5 5 decreased circulating parathyroid hormone level 0.531247329476789 0.676986543070448 0.578184591914569 0.5 5.5 5 5 delayed dark adaptation 0.531247329476789 0.676986543070448 0.578184591914569 0.5 5.5 5 5 intestinal edema 0.531247329476789 0.676986543070448 0.578184591914569 0.5 5.5 5 5 lymphedema 0.531247329476789 0.676986543070448 0.578184591914569 0.5 5.5 5 5 increased defecation amount 0.531247329476789 0.676986543070448 0.578184591914569 0.5 5.5 5 5 decreased prolactin level 0.531247329476789 0.676986543070448 0.578184591914569 0.5 5.5 5 5 abnormal developmental vascular remodeling 0.531247329476789 0.676986543070448 0.578184591914569 0.5 5.5 5 5 crystalluria 0.531247329476789 0.676986543070448 0.578184591914569 0.5 5.5 5 5 increased T-helper 17 cell number 0.531247329476789 0.676986543070448 0.578184591914569 0.5 5.5 5 5 abnormal vibrissa follicle morphology 0.531247329476789 0.676986543070448 0.578184591914569 0.5 5.5 5 5 increased compact bone area 0.531247329476789 0.676986543070448 0.578184591914569 0.5 5.5 5 5 decreased monocyte cell number 0.366905392275239 0.59769918495045 0.569289444346653 0.492307692307692 5.5 5 5 altered response to myocardial infarction 0.423836198961215 0.59769918495045 0.565336045427579 0.488888888888889 5.5 5 5 increased susceptibility to parasitic infection 0.353797755808239 0.59769918495045 0.565336045427579 0.488888888888889 5.5 5 5 increased tumor growth/size 0.438061615021697 0.59769918495045 0.56408252869714 0.48780487804878 5.5 5 5 increased eosinophil cell number 0.423328249933516 0.59769918495045 0.559533476046357 0.483870967741935 5.5 5 5 abnormal body temperature homeostasis 0.480480234245118 0.61863073637926 0.559533476046357 0.483870967741935 5.5 5 5 abnormal T cell proliferation 0.480480234245118 0.61863073637926 0.559533476046357 0.483870967741935 5.5 5 5 abnormal keratinocyte physiology 0.512957111925343 0.656537595016358 0.555057208237986 0.48 5.5 5 5 abnormal stomach mucosa morphology 0.512957111925343 0.656537595016358 0.555057208237986 0.48 5.5 5 5 increased vasoconstriction 0.539295826160163 0.686715314857131 0.550651992299589 0.476190476190476 5.5 5 5 dry skin 0.539295826160163 0.686715314857131 0.550651992299589 0.476190476190476 5.5 5 5 increased bone ossification 0.539295826160163 0.686715314857131 0.550651992299589 0.476190476190476 5.5 5 5 impaired ovarian folliculogenesis 0.504733774753165 0.648013039844386 0.549275362318841 0.475 5.5 5 5 increased hepatoma incidence 0.571358793115766 0.721449237500237 0.544173733566653 0.470588235294118 5.5 5 5 abnormal zygomatic bone morphology 0.590472175999481 0.736979196085655 0.539638952453598 0.466666666666667 5.5 5 5 abnormal lens fiber morphology 0.573022036409142 0.723365803383781 0.533708854074987 0.461538461538462 5.5 5 5 abnormal leukocyte cell number 0.584703162928649 0.731658955566944 0.533708854074987 0.461538461538462 5.5 5 5 increased susceptibility to otitis media 0.584703162928649 0.731658955566944 0.533708854074987 0.461538461538462 5.5 5 5 abnormal membranous labyrinth morphology 0.612470382704634 0.763477863682174 0.533708854074987 0.461538461538462 5.5 5 5 uterus hypoplasia 0.612470382704634 0.763477863682174 0.533708854074987 0.461538461538462 5.5 5 5 abnormal hair follicle inner root sheath morphology 0.612470382704634 0.763477863682174 0.533708854074987 0.461538461538462 5.5 5 5 abnormal immune system physiology 0.571000816542068 0.721180264609492 0.531556802244039 0.459677419354839 5.5 5 5 increased circulating total protein level 0.599591985944693 0.747986491994696 0.530002542588355 0.458333333333333 5.5 5 5 delayed wound healing 0.595758381145763 0.743390505693546 0.52790767087852 0.456521739130435 5.5 5 5 intestinal ulcer 0.615790798767998 0.767232462777558 0.525622356285972 0.454545454545455 5.5 5 5 decreased susceptibility to viral infection induced morbidity/mortality 0.615790798767998 0.767232462777558 0.525622356285972 0.454545454545455 5.5 5 5 increased mast cell number 0.63837805262066 0.777081187126935 0.525622356285972 0.454545454545455 5.5 5 5 rectal hemorrhage 0.63837805262066 0.777081187126935 0.525622356285972 0.454545454545455 5.5 5 5 enlarged placenta 0.63837805262066 0.777081187126935 0.525622356285972 0.454545454545455 5.5 5 5 increased number of Howell-Jolly bodies 0.63837805262066 0.777081187126935 0.525622356285972 0.454545454545455 5.5 5 5 increased subcutaneous adipose tissue amount 0.63837805262066 0.777081187126935 0.525622356285972 0.454545454545455 5.5 5 5 abnormal intestine physiology 0.622047589155135 0.769536017616825 0.522231244309933 0.451612903225806 5.5 5 5 abnormal fibula morphology 0.633549342167593 0.772147961118024 0.520366132723112 0.45 5.5 5 5 abnormal retinal rod cell morphology 0.653193104111502 0.794726263867626 0.513941859479617 0.444444444444444 5.5 5 5 increased susceptibility to autoimmune disorder 0.653193104111502 0.794726263867626 0.513941859479617 0.444444444444444 5.5 5 5 abnormal intestinal mucosa morphology 0.669011658497363 0.811815465595352 0.510953825412875 0.441860465116279 5.5 5 5 increased susceptibility to viral infection induced morbidity/mortality 0.667017655464875 0.811347881647372 0.510162875218737 0.441176470588235 5.5 5 5 impaired natural killer cell mediated cytotoxicity 0.695316422394318 0.814235045392654 0.507179466591727 0.43859649122807 5.5 5 5 mixed cellular infiltration to dermis 0.675155893384444 0.814235045392654 0.505911517925248 0.4375 5.5 5 5 abnormal extraembryonic endoderm formation 0.675155893384444 0.814235045392654 0.505911517925248 0.4375 5.5 5 5 abnormal epididymis epithelium morphology 0.675155893384444 0.814235045392654 0.505911517925248 0.4375 5.5 5 5 abnormal pancreatic alpha cell morphology 0.675155893384444 0.814235045392654 0.505911517925248 0.4375 5.5 5 5 abnormal fertilization 0.675155893384444 0.814235045392654 0.505911517925248 0.4375 5.5 5 5 abnormal leukocyte adhesion 0.693494831456808 0.814235045392654 0.504058362181932 0.435897435897436 5.5 5 5 abnormal retinal cone cell morphology 0.685210186878138 0.814235045392654 0.502769210360495 0.434782608695652 5.5 5 5 abnormal hair cuticle 0.700031129559446 0.814235045392654 0.495586793069631 0.428571428571429 5.5 5 5 abnormal bile salt homeostasis 0.704239479173165 0.814235045392654 0.495586793069631 0.428571428571429 5.5 5 5 abnormal nail morphology 0.725002346684392 0.828217376522353 0.486892287928058 0.421052631578947 5.5 5 5 decreased germ cell number 0.725002346684392 0.828217376522353 0.486892287928058 0.421052631578947 5.5 5 5 decreased susceptibility to bacterial infection induced morbidity/mortality 0.749359241214052 0.855060143357777 0.48492901257351 0.419354838709677 5.5 5 5 abnormal supraoccipital bone morphology 0.728655580589449 0.831626867041181 0.481820493262141 0.416666666666667 5.5 5 5 increased urine phosphate level 0.728655580589449 0.831626867041181 0.481820493262141 0.416666666666667 5.5 5 5 increased placenta weight 0.728655580589449 0.831626867041181 0.481820493262141 0.416666666666667 5.5 5 5 abnormal anogenital distance 0.728655580589449 0.831626867041181 0.481820493262141 0.416666666666667 5.5 5 5 abnormal circulating glucose level 0.765037603762977 0.864621099209635 0.478497593308609 0.413793103448276 5.5 5 5 joint inflammation 0.773070431932756 0.873501112619909 0.462547673531655 0.4 5.5 5 5 salivary gland inflammation 0.811082350338947 0.910865619172971 0.462547673531655 0.4 5.5 5 5 abnormal feces composition 0.798835245077736 0.902034243512805 0.462547673531655 0.4 5.5 5 5 decreased acute inflammation 0.798835245077736 0.902034243512805 0.462547673531655 0.4 5.5 5 5 abnormal regulatory T cell physiology 0.817070820065405 0.917176744094176 0.452492289324445 0.391304347826087 5.5 5 5 increased susceptibility to fungal infection 0.817070820065405 0.917176744094176 0.452492289324445 0.391304347826087 5.5 5 5 abnormal iron level 0.808027074138619 0.907639352865122 0.449699127044665 0.388888888888889 5.5 5 5 impaired leukocyte tethering or rolling 0.808027074138619 0.907639352865122 0.449699127044665 0.388888888888889 5.5 5 5 abnormal mast cell morphology 0.801271329267457 0.902034243512805 0.444757378395822 0.384615384615385 5.5 5 5 decreased follicle stimulating hormone level 0.801271329267457 0.902034243512805 0.444757378395822 0.384615384615385 5.5 5 5 abnormal gut flora balance 0.801271329267457 0.902034243512805 0.444757378395822 0.384615384615385 5.5 5 5 increased acute inflammation 0.836267346940162 0.931971301275873 0.440521593839672 0.380952380952381 5.5 5 5 increased susceptibility to induced arthritis 0.864311612108025 0.947751877945212 0.438622793866225 0.379310344827586 5.5 5 5 abnormal intestinal lipid absorption 0.831819155061744 0.931971301275873 0.433638443935927 0.375 5.5 5 5 abnormal cellular extravasation 0.859493685292002 0.942676605892353 0.433638443935927 0.375 5.5 5 5 abnormal kidney medulla morphology 0.857515884660797 0.940714779754678 0.412988994224692 0.357142857142857 5.5 5 5 abnormal renal reabsorbtion 0.857515884660797 0.940714779754678 0.412988994224692 0.357142857142857 5.5 5 5 nephrocalcinosis 0.877640223146776 0.960884707340496 0.40813030017499 0.352941176470588 5.5 5 5 abnormal circulating cytokine level 0.894412783733529 0.979032695065854 0.404729214340198 0.35 5.5 5 5 decreased chondrocyte number 0.899738611024817 0.984645752276389 0.385456394609713 0.333333333333333 5.5 5 5 altered susceptibility to infection 0.938287704957288 1 0.365169215946044 0.315789473684211 5.5 5 5 increased urine calcium level 0.986069916897445 1 0.289092295957284 0.25 5.5 5 5 matted coat 0.000127133166725476 0.00306996818998115 3.45840452096202 1 6.1 6 1 abnormal circulating serum amyloid protein level 6.38739910861509e-06 0.000241151955706476 3.45840452096202 1 6.1 6 1 loss of vibrissae 0.00056710019491865 0.010410787711145 3.45840452096202 1 6.1 6 1 increased keratinocyte apoptosis 0.000718944467341237 0.01239392637058 2.96434673225316 0.857142857142857 6.1 6 1 absent popliteal lymph nodes 0.000718944467341237 0.01239392637058 2.96434673225316 0.857142857142857 6.1 6 1 chromatolysis 0.00276693533588452 0.0338715169239721 2.88200376746835 0.833333333333333 6.1 6 1 abnormal plasma membrane morphology 0.000184461478059011 0.00417134478792535 2.76672361676961 0.8 6.1 6 1 increased circulating fructosamine level 0.000184461478059011 0.00417134478792535 2.76672361676961 0.8 6.1 6 1 abnormal vascular endothelial cell migration 1.3145764667244e-05 0.00044489917836421 2.71731783789873 0.785714285714286 6.1 6 1 axonal dystrophy 4.64004779739086e-05 0.00132668033287468 2.66031116997078 0.769230769230769 6.1 6 1 schistocytosis 0.00232596245169749 0.0302923120345419 2.59380339072151 0.75 6.1 6 1 decreased aerobic running capacity 0.00232596245169749 0.0302923120345419 2.59380339072151 0.75 6.1 6 1 altered response to CNS ischemic injury 0.00232596245169749 0.0302923120345419 2.59380339072151 0.75 6.1 6 1 binucleate 0.00232596245169749 0.0302923120345419 2.59380339072151 0.75 6.1 6 1 abnormal kidney epithelium morphology 0.00232596245169749 0.0302923120345419 2.59380339072151 0.75 6.1 6 1 abnormal somite size 0.00232596245169749 0.0302923120345419 2.59380339072151 0.75 6.1 6 1 abnormal vertebral body development 0.00232596245169749 0.0302923120345419 2.59380339072151 0.75 6.1 6 1 stomach epithelial hyperplasia 0.00232596245169749 0.0302923120345419 2.59380339072151 0.75 6.1 6 1 embryonic lethality between implantation and somite formation, incomplete penetrance 2.91799856001917e-06 0.000131973116691776 2.54829806807728 0.736842105263158 6.1 6 1 increased thymocyte apoptosis 5.63477687093386e-08 5.28217557453354e-06 2.52729561147224 0.730769230769231 6.1 6 1 abnormal enterocyte morphology 7.33688290824693e-07 4.01109807346467e-05 2.51520328797238 0.727272727272727 6.1 6 1 increased skin papilloma incidence 7.33688290824693e-07 4.01109807346467e-05 2.51520328797238 0.727272727272727 6.1 6 1 pathological neovascularization 0.0005424675940829 0.0101077763316945 2.51520328797238 0.727272727272727 6.1 6 1 abnormal hair medulla 0.0005424675940829 0.0101077763316945 2.51520328797238 0.727272727272727 6.1 6 1 abnormal dorsal-ventral polarity of the somites 0.0005424675940829 0.0101077763316945 2.51520328797238 0.727272727272727 6.1 6 1 abnormal pancreas development 0.000129537261240571 0.00309830708976846 2.4702889435443 0.714285714285714 6.1 6 1 asymmetric rib joints 0.00788691250724275 0.0736161158040013 2.4702889435443 0.714285714285714 6.1 6 1 abnormal circulating free fatty acids level 0.00788691250724275 0.0736161158040013 2.4702889435443 0.714285714285714 6.1 6 1 abnormal prostaglandin level 0.00788691250724275 0.0736161158040013 2.4702889435443 0.714285714285714 6.1 6 1 decreased brain cholesterol level 0.00788691250724275 0.0736161158040013 2.4702889435443 0.714285714285714 6.1 6 1 abnormal tricarboxylic acid cycle 0.00788691250724275 0.0736161158040013 2.4702889435443 0.714285714285714 6.1 6 1 decreased CD8-positive, naive alpha-beta T cell number 0.00788691250724275 0.0736161158040013 2.4702889435443 0.714285714285714 6.1 6 1 abnormal glial cell physiology 0.00178159636609296 0.0255430602919668 2.42088316467341 0.7 6.1 6 1 abnormal gas homeostasis 0.00178159636609296 0.0255430602919668 2.42088316467341 0.7 6.1 6 1 crystalluria 0.00178159636609296 0.0255430602919668 2.42088316467341 0.7 6.1 6 1 abnormal vibrissa follicle morphology 0.00178159636609296 0.0255430602919668 2.42088316467341 0.7 6.1 6 1 decreased circulating lactate level 0.00178159636609296 0.0255430602919668 2.42088316467341 0.7 6.1 6 1 abnormal exocrine pancreas morphology 0.000417354617099666 0.00811070007840171 2.39428005297371 0.692307692307692 6.1 6 1 abnormal hair follicle orientation 9.99429615351624e-05 0.00251119309917895 2.37765310816139 0.6875 6.1 6 1 decreased cellular sensitivity to gamma-irradiation 7.49252606263761e-05 0.00197223900326043 2.30560301397468 0.666666666666667 6.1 6 1 delayed intramembranous bone ossification 0.00031015517137568 0.00628323481385865 2.30560301397468 0.666666666666667 6.1 6 1 abnormal branching involved in lung morphogenesis 0.00031015517137568 0.00628323481385865 2.30560301397468 0.666666666666667 6.1 6 1 amyloidosis 0.00130632235606964 0.0197536587278008 2.30560301397468 0.666666666666667 6.1 6 1 abnormal fatty acid level 0.00130632235606964 0.0197536587278008 2.30560301397468 0.666666666666667 6.1 6 1 heart hyperplasia 0.00565068346615407 0.0576068652543371 2.30560301397468 0.666666666666667 6.1 6 1 distorted hair follicle pattern 0.00565068346615407 0.0576068652543371 2.30560301397468 0.666666666666667 6.1 6 1 renal tubular acidosis 0.00565068346615407 0.0576068652543371 2.30560301397468 0.666666666666667 6.1 6 1 wavy vibrissae 0.00565068346615407 0.0576068652543371 2.30560301397468 0.666666666666667 6.1 6 1 abnormal ion homeostasis 0.00565068346615407 0.0576068652543371 2.30560301397468 0.666666666666667 6.1 6 1 positive geotaxis 0.00565068346615407 0.0576068652543371 2.30560301397468 0.666666666666667 6.1 6 1 shortened ST segment 0.00565068346615407 0.0576068652543371 2.30560301397468 0.666666666666667 6.1 6 1 symmetric azygos veins 0.00565068346615407 0.0576068652543371 2.30560301397468 0.666666666666667 6.1 6 1 intestinal obstruction 0.000935425857646039 0.0149638059221513 2.22326004918987 0.642857142857143 6.1 6 1 abnormal maternal decidual layer morphology 0.000935425857646039 0.0149638059221513 2.22326004918987 0.642857142857143 6.1 6 1 abnormal thrombopoiesis 0.00395007171711059 0.0448666821749434 2.20080287697583 0.636363636363636 6.1 6 1 loss of cortex neurons 0.00395007171711059 0.0448666821749434 2.20080287697583 0.636363636363636 6.1 6 1 common atrioventricular valve 0.00395007171711059 0.0448666821749434 2.20080287697583 0.636363636363636 6.1 6 1 short vibrissae 0.000161731181285321 0.00374238431113707 2.18425548692338 0.631578947368421 6.1 6 1 decreased circulating triiodothyronine level 0.000660508854443211 0.0116114189076148 2.16150282560126 0.625 6.1 6 1 abnormal exoccipital bone morphology 0.0171551625998182 0.118373001295555 2.16150282560126 0.625 6.1 6 1 abnormal cecum morphology 0.0171551625998182 0.118373001295555 2.16150282560126 0.625 6.1 6 1 dry eyes 0.0171551625998182 0.118373001295555 2.16150282560126 0.625 6.1 6 1 abnormal urination 0.0171551625998182 0.118373001295555 2.16150282560126 0.625 6.1 6 1 liver failure 0.0171551625998182 0.118373001295555 2.16150282560126 0.625 6.1 6 1 abnormal skin development 0.0171551625998182 0.118373001295555 2.16150282560126 0.625 6.1 6 1 long femur 0.0171551625998182 0.118373001295555 2.16150282560126 0.625 6.1 6 1 abnormal sphingomyelin level 0.0171551625998182 0.118373001295555 2.16150282560126 0.625 6.1 6 1 abnormal cerebellum deep nucleus morphology 0.0171551625998182 0.118373001295555 2.16150282560126 0.625 6.1 6 1 increased heart right ventricle size 0.0171551625998182 0.118373001295555 2.16150282560126 0.625 6.1 6 1 increased cardiac stroke volume 0.0171551625998182 0.118373001295555 2.16150282560126 0.625 6.1 6 1 absent myocardial trabeculae 0.0027286707384216 0.0336018240684343 2.12824893597663 0.615384615384615 6.1 6 1 increased foot pad pigmentation 0.0027286707384216 0.0336018240684343 2.12824893597663 0.615384615384615 6.1 6 1 lethality, incomplete penetrance 3.20061051965917e-08 3.38788028410732e-06 2.12220277422669 0.613636363636364 6.1 6 1 abnormal intestine physiology 3.68938028202018e-06 0.000154240898344961 2.11966728704124 0.612903225806452 6.1 6 1 decreased lactate dehydrogenase level 0.000462295824704051 0.00884585279962558 2.11346942947679 0.611111111111111 6.1 6 1 impaired leukocyte tethering or rolling 0.000462295824704051 0.00884585279962558 2.11346942947679 0.611111111111111 6.1 6 1 increased adipocyte glucose uptake 0.000462295824704051 0.00884585279962558 2.11346942947679 0.611111111111111 6.1 6 1 prolonged QRS complex duration 1.44683437721333e-05 0.000479866735109088 2.09974560201265 0.607142857142857 6.1 6 1 abnormal keratinocyte physiology 5.678552149207e-05 0.00158712342372499 2.07504271257721 0.6 6.1 6 1 liver vascular congestion 0.00187333188705158 0.0263260752910136 2.07504271257721 0.6 6.1 6 1 abnormal coronary vessel morphology 0.00187333188705158 0.0263260752910136 2.07504271257721 0.6 6.1 6 1 decreased brown adipose tissue mass 0.00187333188705158 0.0263260752910136 2.07504271257721 0.6 6.1 6 1 retarded hair growth 0.0114543141162457 0.0897404924855472 2.07504271257721 0.6 6.1 6 1 increased cranium width 0.0114543141162457 0.0897404924855472 2.07504271257721 0.6 6.1 6 1 enlarged testis 0.0114543141162457 0.0897404924855472 2.07504271257721 0.6 6.1 6 1 abnormal immune cell physiology 0.0114543141162457 0.0897404924855472 2.07504271257721 0.6 6.1 6 1 decreased incidence of induced tumors 0.0114543141162457 0.0897404924855472 2.07504271257721 0.6 6.1 6 1 ketoaciduria 0.0114543141162457 0.0897404924855472 2.07504271257721 0.6 6.1 6 1 abnormal submandibular gland morphology 0.0114543141162457 0.0897404924855472 2.07504271257721 0.6 6.1 6 1 increased atrioventricular cushion size 0.0114543141162457 0.0897404924855472 2.07504271257721 0.6 6.1 6 1 abnormal gonadal fat pad morphology 0.0114543141162457 0.0897404924855472 2.07504271257721 0.6 6.1 6 1 absent axillary lymph nodes 0.0114543141162457 0.0897404924855472 2.07504271257721 0.6 6.1 6 1 abnormal heart and great artery attachment 0.0114543141162457 0.0897404924855472 2.07504271257721 0.6 6.1 6 1 thin ventricle myocardium compact layer 0.0114543141162457 0.0897404924855472 2.07504271257721 0.6 6.1 6 1 thick aortic valve 0.0114543141162457 0.0897404924855472 2.07504271257721 0.6 6.1 6 1 decreased macrophage apoptosis 0.0114543141162457 0.0897404924855472 2.07504271257721 0.6 6.1 6 1 decreased width of hypertrophic chondrocyte zone 1.3085446758204e-06 6.64286710429235e-05 2.05634863408552 0.594594594594595 6.1 6 1 abnormal vascular branching morphogenesis 0.000222991552881048 0.00493059100259206 2.04360267147756 0.590909090909091 6.1 6 1 abnormal adipose tissue morphology 0.00128185097667807 0.0196327020566674 2.03435560056589 0.588235294117647 6.1 6 1 abnormal circulating chemokine level 0.00128185097667807 0.0196327020566674 2.03435560056589 0.588235294117647 6.1 6 1 abnormal cell death 1.19604101190455e-07 9.29735005347676e-06 2.02993308839075 0.58695652173913 6.1 6 1 abnormal cell differentiation 6.459357874242e-07 3.69371326716712e-05 2.02443191470947 0.585365853658537 6.1 6 1 abnormal thymus involution 0.0076513208225679 0.0725053735090958 2.01740263722784 0.583333333333333 6.1 6 1 interstitial pneumonia 0.0076513208225679 0.0725053735090958 2.01740263722784 0.583333333333333 6.1 6 1 increased litter size 0.0076513208225679 0.0725053735090958 2.01740263722784 0.583333333333333 6.1 6 1 small intestinal inflammation 0.0076513208225679 0.0725053735090958 2.01740263722784 0.583333333333333 6.1 6 1 increased hepatocyte proliferation 0.0076513208225679 0.0725053735090958 2.01740263722784 0.583333333333333 6.1 6 1 pale placenta 0.0076513208225679 0.0725053735090958 2.01740263722784 0.583333333333333 6.1 6 1 hemoperitoneum 0.0076513208225679 0.0725053735090958 2.01740263722784 0.583333333333333 6.1 6 1 decreased keratinocyte proliferation 0.0076513208225679 0.0725053735090958 2.01740263722784 0.583333333333333 6.1 6 1 embryonic lethality between implantation and placentation, incomplete penetrance 0.0076513208225679 0.0725053735090958 2.01740263722784 0.583333333333333 6.1 6 1 abnormal bile salt homeostasis 0.000597532800193901 0.0107318616641323 1.97623115483544 0.571428571428571 6.1 6 1 increased keratinocyte proliferation 0.000597532800193901 0.0107318616641323 1.97623115483544 0.571428571428571 6.1 6 1 abnormal fluid regulation 0.00511966391278903 0.0539625592502657 1.97623115483544 0.571428571428571 6.1 6 1 increased circulating growth hormone level 0.00511966391278903 0.0539625592502657 1.97623115483544 0.571428571428571 6.1 6 1 spina bifida occulta 0.00511966391278903 0.0539625592502657 1.97623115483544 0.571428571428571 6.1 6 1 abnormal renal reabsorbtion 0.00511966391278903 0.0539625592502657 1.97623115483544 0.571428571428571 6.1 6 1 abnormal epidermis stratum corneum morphology 1.5404947584333e-07 1.12705315047142e-05 1.97623115483544 0.571428571428571 6.1 6 1 abnormal hematopoietic stem cell physiology 0.000407637228146185 0.00795869105305736 1.95475038141332 0.565217391304348 6.1 6 1 abnormal intestinal absorption 0.00343267578611949 0.0401824989081046 1.94535254304114 0.5625 6.1 6 1 increased thymus weight 0.00343267578611949 0.0401824989081046 1.94535254304114 0.5625 6.1 6 1 spontaneous skin ulceration 0.000278077263892342 0.00583727589816203 1.93670653173873 0.56 6.1 6 1 abnormal neutrophil morphology 0.00230629491664559 0.0302923120345419 1.9213358449789 0.555555555555556 6.1 6 1 abnormal urinary bladder urothelium morphology 0.0315357615168982 0.177678837538583 1.9213358449789 0.555555555555556 6.1 6 1 dilated uterus 0.0315357615168982 0.177678837538583 1.9213358449789 0.555555555555556 6.1 6 1 psoriasis 0.0315357615168982 0.177678837538583 1.9213358449789 0.555555555555556 6.1 6 1 long gestation period 0.0315357615168982 0.177678837538583 1.9213358449789 0.555555555555556 6.1 6 1 decreased circulating bicarbonate level 0.0315357615168982 0.177678837538583 1.9213358449789 0.555555555555556 6.1 6 1 biliary cyst 0.0315357615168982 0.177678837538583 1.9213358449789 0.555555555555556 6.1 6 1 premature neuronal precursor differentiation 0.0315357615168982 0.177678837538583 1.9213358449789 0.555555555555556 6.1 6 1 abnormal stria vascularis vasculature morphology 0.0315357615168982 0.177678837538583 1.9213358449789 0.555555555555556 6.1 6 1 increased circulating progesterone level 0.0315357615168982 0.177678837538583 1.9213358449789 0.555555555555556 6.1 6 1 abnormal intervertebral disk development 0.0315357615168982 0.177678837538583 1.9213358449789 0.555555555555556 6.1 6 1 iris coloboma 0.0315357615168982 0.177678837538583 1.9213358449789 0.555555555555556 6.1 6 1 decreased pancreatic beta cell proliferation 0.0315357615168982 0.177678837538583 1.9213358449789 0.555555555555556 6.1 6 1 cerebellum atrophy 0.0315357615168982 0.177678837538583 1.9213358449789 0.555555555555556 6.1 6 1 decreased platelet dense granule number 0.0315357615168982 0.177678837538583 1.9213358449789 0.555555555555556 6.1 6 1 increased susceptibility to weight loss 7.75011938029168e-06 0.000281436816912052 1.90212248652911 0.55 6.1 6 1 waved hair 0.00155252636298468 0.0229193431924297 1.90212248652911 0.55 6.1 6 1 anencephaly 0.00155252636298468 0.0229193431924297 1.90212248652911 0.55 6.1 6 1 prolonged PR interval 0.00104698229696933 0.0165883341637656 1.88640246597928 0.545454545454545 6.1 6 1 focal hepatic necrosis 0.0204594049952079 0.134815284571072 1.88640246597928 0.545454545454545 6.1 6 1 rectal hemorrhage 0.0204594049952079 0.134815284571072 1.88640246597928 0.545454545454545 6.1 6 1 increased circulating triiodothyronine level 0.0204594049952079 0.134815284571072 1.88640246597928 0.545454545454545 6.1 6 1 abnormal palate development 0.0204594049952079 0.134815284571072 1.88640246597928 0.545454545454545 6.1 6 1 aorta dilation 0.0204594049952079 0.134815284571072 1.88640246597928 0.545454545454545 6.1 6 1 abnormal myelin sheath morphology 2.51463476831686e-06 0.000118021773324305 1.87956767443588 0.543478260869565 6.1 6 1 curly vibrissae 0.000707208448143814 0.012301965138166 1.87330244885443 0.541666666666667 6.1 6 1 increased body temperature 0.000707208448143814 0.012301965138166 1.87330244885443 0.541666666666667 6.1 6 1 absent teeth 0.0133944125874052 0.100508601240333 1.86221781897955 0.538461538461538 6.1 6 1 short hair 0.0133944125874052 0.100508601240333 1.86221781897955 0.538461538461538 6.1 6 1 abnormal grip strength 0.0133944125874052 0.100508601240333 1.86221781897955 0.538461538461538 6.1 6 1 abnormal coping response 0.0133944125874052 0.100508601240333 1.86221781897955 0.538461538461538 6.1 6 1 abnormal soleus morphology 0.0133944125874052 0.100508601240333 1.86221781897955 0.538461538461538 6.1 6 1 abnormal vertebral arch development 0.0133944125874052 0.100508601240333 1.86221781897955 0.538461538461538 6.1 6 1 increased circulating ammonia level 0.0133944125874052 0.100508601240333 1.86221781897955 0.538461538461538 6.1 6 1 abnormal small intestine morphology 5.61018878575209e-07 3.32270109632341e-05 1.85729131681294 0.537037037037037 6.1 6 1 abnormal apoptosis 5.61018878575209e-07 3.32270109632341e-05 1.85729131681294 0.537037037037037 6.1 6 1 epidermal hyperplasia 1.82293577492353e-07 1.27641825896972e-05 1.84448241117974 0.533333333333333 6.1 6 1 increased erythrocyte cell number 1.82293577492353e-07 1.27641825896972e-05 1.84448241117974 0.533333333333333 6.1 6 1 abnormal fat pad morphology 0.000219783334095794 0.00488134860324364 1.84448241117974 0.533333333333333 6.1 6 1 absent incisors 0.00882975765648896 0.0794358848843266 1.84448241117974 0.533333333333333 6.1 6 1 vagina atresia 0.00882975765648896 0.0794358848843266 1.84448241117974 0.533333333333333 6.1 6 1 placental labyrinth hypoplasia 0.00882975765648896 0.0794358848843266 1.84448241117974 0.533333333333333 6.1 6 1 abnormal lymph node B cell domain morphology 0.00882975765648896 0.0794358848843266 1.84448241117974 0.533333333333333 6.1 6 1 abnormal energy homeostasis 0.00882975765648896 0.0794358848843266 1.84448241117974 0.533333333333333 6.1 6 1 decreased thymocyte apoptosis 0.00882975765648896 0.0794358848843266 1.84448241117974 0.533333333333333 6.1 6 1 bicuspid aortic valve 0.00882975765648896 0.0794358848843266 1.84448241117974 0.533333333333333 6.1 6 1 small placenta 6.17434989161838e-06 0.000236287620852319 1.84448241117974 0.533333333333333 6.1 6 1 increased dopamine level 0.00014922415150227 0.0034691128678682 1.83727740176107 0.53125 6.1 6 1 abnormal embryonic hematopoiesis 0.00014922415150227 0.0034691128678682 1.83727740176107 0.53125 6.1 6 1 increased fibroblast apoptosis 0.00014922415150227 0.0034691128678682 1.83727740176107 0.53125 6.1 6 1 abnormal brown adipose tissue morphology 0.000101419699437992 0.00253549248594981 1.8309200405093 0.529411764705882 6.1 6 1 aminoaciduria 0.00585235369674107 0.0592982884751259 1.8309200405093 0.529411764705882 6.1 6 1 thick epidermis 2.80545050655902e-08 3.03415571089807e-06 1.82801381822278 0.528571428571429 6.1 6 1 kyphoscoliosis 0.00389598681357981 0.0448666821749434 1.82021290576948 0.526315789473684 6.1 6 1 abnormal stationary movement 0.00389598681357981 0.0448666821749434 1.82021290576948 0.526315789473684 6.1 6 1 increased left ventricle weight 0.00389598681357981 0.0448666821749434 1.82021290576948 0.526315789473684 6.1 6 1 increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 0.00389598681357981 0.0448666821749434 1.82021290576948 0.526315789473684 6.1 6 1 abnormal tumor vascularization 0.00260301928205454 0.0325377410256818 1.81154522526582 0.523809523809524 6.1 6 1 abnormal myelopoiesis 1.48912837988041e-05 0.000487395637493754 1.80780236323015 0.522727272727273 6.1 6 1 failure to gastrulate 1.01667663897655e-05 0.000353703935587994 1.80438496745844 0.521739130434783 6.1 6 1 abnormal placenta vasculature 3.24592566802624e-06 0.00014290690441089 1.79571003973028 0.519230769230769 6.1 6 1 increased brain weight 0.000789298659372605 0.0133563293550296 1.79324678864697 0.518518518518518 6.1 6 1 decreased circulating fructosamine level 0.000789298659372605 0.0133563293550296 1.79324678864697 0.518518518518518 6.1 6 1 abnormal capillary morphology 0.000359936140603481 0.00722049314315451 1.78498297856104 0.516129032258065 6.1 6 1 pale kidney 0.000359936140603481 0.00722049314315451 1.78498297856104 0.516129032258065 6.1 6 1 increased cardiomyocyte apoptosis 0.000243637944329221 0.00529300774252346 1.78160232898043 0.515151515151515 6.1 6 1 abnormal hepatocyte morphology 2.58351633205138e-11 7.14055208441979e-09 1.77593745671023 0.513513513513513 6.1 6 1 increased erythroid progenitor cell number 0.000112066968680862 0.00276006519399647 1.77593745671023 0.513513513513513 6.1 6 1 increased hepatocyte apoptosis 7.61338984333057e-05 0.00199350602476682 1.77354077998052 0.512820512820513 6.1 6 1 abnormal pancreatic islet morphology 5.20430420054255e-06 0.000203869396832277 1.76182871822593 0.509433962264151 6.1 6 1 increased circulating bilirubin level 5.20430420054255e-06 0.000203869396832277 1.76182871822593 0.509433962264151 6.1 6 1 abnormal erythropoiesis 2.89720874722326e-10 5.33837537682804e-08 1.74567085343797 0.504761904761905 6.1 6 1 pale liver 1.84727868634814e-07 1.27641825896972e-05 1.72920226048101 0.5 6.1 6 1 muscular atrophy 5.55863937226893e-05 0.00156238592525638 1.72920226048101 0.5 6.1 6 1 abnormal brain vasculature morphology 0.000845321814971684 0.0140549141641681 1.72920226048101 0.5 6.1 6 1 intestinal ulcer 0.00415905626713978 0.0462451260723885 1.72920226048101 0.5 6.1 6 1 parakeratosis 0.00415905626713978 0.0462451260723885 1.72920226048101 0.5 6.1 6 1 abnormal basement membrane morphology 0.00415905626713978 0.0462451260723885 1.72920226048101 0.5 6.1 6 1 decreased susceptibility to viral infection induced morbidity/mortality 0.00415905626713978 0.0462451260723885 1.72920226048101 0.5 6.1 6 1 increased adenoma incidence 0.00415905626713978 0.0462451260723885 1.72920226048101 0.5 6.1 6 1 vertebral transformation 2.57826174896703e-05 0.000796698894478943 1.72920226048101 0.5 6.1 6 1 abnormal hair shaft morphology 2.57826174896703e-05 0.000796698894478943 1.72920226048101 0.5 6.1 6 1 disheveled coat 8.17219676075258e-05 0.00209570509715176 1.72920226048101 0.5 6.1 6 1 decreased hair follicle number 0.000177159881030304 0.00404298352351266 1.72920226048101 0.5 6.1 6 1 abnormal ovulation 0.00125453255714328 0.0193829176142478 1.72920226048101 0.5 6.1 6 1 abnormal lung saccule morphology 0.00278169084140895 0.0339189018039449 1.72920226048101 0.5 6.1 6 1 abnormal stomach glandular epithelium morphology 0.00939841247683653 0.0827183992685586 1.72920226048101 0.5 6.1 6 1 thick dermal layer 0.00939841247683653 0.0827183992685586 1.72920226048101 0.5 6.1 6 1 abnormal thymus medulla morphology 0.00939841247683653 0.0827183992685586 1.72920226048101 0.5 6.1 6 1 acidosis 0.00939841247683653 0.0827183992685586 1.72920226048101 0.5 6.1 6 1 absent allantois 0.00939841247683653 0.0827183992685586 1.72920226048101 0.5 6.1 6 1 darkened coat color 0.00939841247683653 0.0827183992685586 1.72920226048101 0.5 6.1 6 1 abnormal pregnancy 0.00939841247683653 0.0827183992685586 1.72920226048101 0.5 6.1 6 1 midline facial cleft 0.0216691612620215 0.137236332487984 1.72920226048101 0.5 6.1 6 1 abnormal placing response 0.0216691612620215 0.137236332487984 1.72920226048101 0.5 6.1 6 1 increased hemangioma incidence 0.0216691612620215 0.137236332487984 1.72920226048101 0.5 6.1 6 1 abnormal hair cuticle 0.0216691612620215 0.137236332487984 1.72920226048101 0.5 6.1 6 1 vascular smooth muscle hypoplasia 0.0216691612620215 0.137236332487984 1.72920226048101 0.5 6.1 6 1 abnormal sagittal suture morphology 0.0216691612620215 0.137236332487984 1.72920226048101 0.5 6.1 6 1 enlarged stomach 0.0216691612620215 0.137236332487984 1.72920226048101 0.5 6.1 6 1 increased lung compliance 0.0216691612620215 0.137236332487984 1.72920226048101 0.5 6.1 6 1 pulmonary alveolar hemorrhage 0.0216691612620215 0.137236332487984 1.72920226048101 0.5 6.1 6 1 testis degeneration 0.0216691612620215 0.137236332487984 1.72920226048101 0.5 6.1 6 1 mesocardia 0.0332674891678479 0.181913574958076 1.72920226048101 0.5 6.1 6 1 myocarditis 0.0332674891678479 0.181913574958076 1.72920226048101 0.5 6.1 6 1 abnormal embryonic growth/weight/body size 0.0332674891678479 0.181913574958076 1.72920226048101 0.5 6.1 6 1 abnormal nucleotide metabolism 0.0332674891678479 0.181913574958076 1.72920226048101 0.5 6.1 6 1 decreased left ventricle systolic pressure 0.0332674891678479 0.181913574958076 1.72920226048101 0.5 6.1 6 1 abnormal rostral-caudal body axis extension 0.0332674891678479 0.181913574958076 1.72920226048101 0.5 6.1 6 1 decreased renal glomerular filtration rate 0.0332674891678479 0.181913574958076 1.72920226048101 0.5 6.1 6 1 decreased red blood cell distribution width 0.0332674891678479 0.181913574958076 1.72920226048101 0.5 6.1 6 1 persistent right dorsal aorta 0.0332674891678479 0.181913574958076 1.72920226048101 0.5 6.1 6 1 decreased compensatory feeding amount 0.0332674891678479 0.181913574958076 1.72920226048101 0.5 6.1 6 1 increased cell proliferation 8.18800171714421e-06 0.000293059773689154 1.72920226048101 0.5 6.1 6 1 increased fatty acid level 0.000570648129704687 0.0104374060488265 1.72920226048101 0.5 6.1 6 1 abnormal cell proliferation 0.00623944726417491 0.062331827588896 1.72920226048101 0.5 6.1 6 1 abnormal trachea morphology 0.00623944726417491 0.062331827588896 1.72920226048101 0.5 6.1 6 1 decreased myocardial infarction size 0.00623944726417491 0.062331827588896 1.72920226048101 0.5 6.1 6 1 increased skin tumor incidence 0.00623944726417491 0.062331827588896 1.72920226048101 0.5 6.1 6 1 failure of tooth eruption 0.0142268395268584 0.104073196763111 1.72920226048101 0.5 6.1 6 1 decreased mast cell number 0.0142268395268584 0.104073196763111 1.72920226048101 0.5 6.1 6 1 small pancreas 0.0142268395268584 0.104073196763111 1.72920226048101 0.5 6.1 6 1 increased cochlear outer hair cell number 0.0142268395268584 0.104073196763111 1.72920226048101 0.5 6.1 6 1 abnormal intestinal lipid absorption 0.0142268395268584 0.104073196763111 1.72920226048101 0.5 6.1 6 1 decreased liver cholesterol level 0.0142268395268584 0.104073196763111 1.72920226048101 0.5 6.1 6 1 abnormal pulmonary alveolus wall morphology 0.0142268395268584 0.104073196763111 1.72920226048101 0.5 6.1 6 1 kidney hemorrhage 0.0516172089175507 0.220425420055635 1.72920226048101 0.5 6.1 6 1 abnormal epidermis suprabasal layer morphology 0.0516172089175507 0.220425420055635 1.72920226048101 0.5 6.1 6 1 fused cornea and lens 0.0516172089175507 0.220425420055635 1.72920226048101 0.5 6.1 6 1 abnormal gland morphology 0.0516172089175507 0.220425420055635 1.72920226048101 0.5 6.1 6 1 decreased circulating parathyroid hormone level 0.0516172089175507 0.220425420055635 1.72920226048101 0.5 6.1 6 1 impaired basement membrane formation 0.0516172089175507 0.220425420055635 1.72920226048101 0.5 6.1 6 1 aneurysm 0.0516172089175507 0.220425420055635 1.72920226048101 0.5 6.1 6 1 peritoneal inflammation 0.0516172089175507 0.220425420055635 1.72920226048101 0.5 6.1 6 1 abnormal hypaxial muscle morphology 0.0516172089175507 0.220425420055635 1.72920226048101 0.5 6.1 6 1 abnormal pillar cell morphology 0.0516172089175507 0.220425420055635 1.72920226048101 0.5 6.1 6 1 abnormal hindlimb zeugopod morphology 0.0516172089175507 0.220425420055635 1.72920226048101 0.5 6.1 6 1 abnormal placental transport 0.0516172089175507 0.220425420055635 1.72920226048101 0.5 6.1 6 1 abnormal respiratory conducting tube morphology 0.0516172089175507 0.220425420055635 1.72920226048101 0.5 6.1 6 1 increased susceptibility to atherosclerosis 0.0516172089175507 0.220425420055635 1.72920226048101 0.5 6.1 6 1 increased platelet aggregation 0.0516172089175507 0.220425420055635 1.72920226048101 0.5 6.1 6 1 absent inguinal lymph nodes 0.0516172089175507 0.220425420055635 1.72920226048101 0.5 6.1 6 1 protruding tongue 0.0516172089175507 0.220425420055635 1.72920226048101 0.5 6.1 6 1 decreased transitional stage T2 B cell number 0.0516172089175507 0.220425420055635 1.72920226048101 0.5 6.1 6 1 increased T-helper 17 cell number 0.0516172089175507 0.220425420055635 1.72920226048101 0.5 6.1 6 1 aorta stenosis 0.0516172089175507 0.220425420055635 1.72920226048101 0.5 6.1 6 1 abnormal circadian temperature homeostasis 0.0516172089175507 0.220425420055635 1.72920226048101 0.5 6.1 6 1 lethality during fetal growth through weaning, complete penetrance 0.0516172089175507 0.220425420055635 1.72920226048101 0.5 6.1 6 1 increased fatty acid oxidation 0.0516172089175507 0.220425420055635 1.72920226048101 0.5 6.1 6 1 increased bone mineral content 4.83162354639411e-10 8.28873349769334e-08 1.71333801955917 0.495412844036697 6.1 6 1 abnormal placenta morphology 1.34532383082293e-07 1.02969016282217e-05 1.70731362427239 0.493670886075949 6.1 6 1 decreased percent body fat/body weight 4.17016144048208e-07 2.5933191457998e-05 1.70551455828264 0.493150684931507 6.1 6 1 microcephaly 8.8785148983007e-07 4.74952813108021e-05 1.7041413581552 0.492753623188406 6.1 6 1 abnormal colon morphology 5.90986697988424e-06 0.000227919288565303 1.6998937475915 0.491525423728814 6.1 6 1 abnormal trophoblast layer morphology 2.71551769311634e-05 0.000833932131065049 1.69529633380491 0.490196078431373 6.1 6 1 skin inflammation 0.000402648383617699 0.00795869105305736 1.68246706425179 0.486486486486487 6.1 6 1 lethality throughout fetal growth and development, incomplete penetrance 1.19258542574686e-14 5.3937386300824e-12 1.68090052136143 0.486033519553073 6.1 6 1 abnormal intestinal goblet cell morphology 0.000594311459115012 0.0107318616641323 1.67979648161012 0.485714285714286 6.1 6 1 decreased circulating thyroxine level 0.000594311459115012 0.0107318616641323 1.67979648161012 0.485714285714286 6.1 6 1 decreased brown adipose tissue amount 0.000878422421822779 0.0143283657330109 1.67680219198158 0.484848484848485 6.1 6 1 myeloid hyperplasia 0.000878422421822779 0.0143283657330109 1.67680219198158 0.484848484848485 6.1 6 1 decreased thymus weight 0.00130037088469188 0.0197536587278008 1.67342154240098 0.483870967741935 6.1 6 1 abnormal eating behavior 8.99330949362087e-06 0.000319583676648313 1.67156218513164 0.483333333333333 6.1 6 1 abnormal middle ear morphology 0.00192838054091217 0.0268069157477291 1.66957459632649 0.482758620689655 6.1 6 1 abnormal neural tube closure 2.1373453490615e-07 1.41777241487746e-05 1.6667009739576 0.481927710843373 6.1 6 1 thin epidermis 0.00286539574109092 0.0347691312486033 1.66515773231505 0.481481481481481 6.1 6 1 liver hypoplasia 4.1193602878455e-05 0.00118461372439488 1.66269448123174 0.480769230769231 6.1 6 1 abnormal liver physiology 1.60441771755746e-08 1.90047098686866e-06 1.66003417006177 0.48 6.1 6 1 ruffled hair 0.00426746648170993 0.0465584336546204 1.66003417006177 0.48 6.1 6 1 abnormal preimplantation embryo development 0.00426746648170993 0.0465584336546204 1.66003417006177 0.48 6.1 6 1 abnormal pulmonary artery morphology 0.00637244567097287 0.0625291928096841 1.65401955350357 0.478260869565217 6.1 6 1 abnormal postnatal growth 0.00637244567097287 0.0625291928096841 1.65401955350357 0.478260869565217 6.1 6 1 decreased epididymis weight 0.00637244567097287 0.0625291928096841 1.65401955350357 0.478260869565217 6.1 6 1 abnormal hepatocyte physiology 0.00637244567097287 0.0625291928096841 1.65401955350357 0.478260869565217 6.1 6 1 decreased effector memory CD8-positive, alpha-beta T cell number 0.00637244567097287 0.0625291928096841 1.65401955350357 0.478260869565217 6.1 6 1 dry skin 0.00954529088428432 0.0832766595900406 1.6468592956962 0.476190476190476 6.1 6 1 decreased cochlear outer hair cell number 0.00954529088428432 0.0832766595900406 1.6468592956962 0.476190476190476 6.1 6 1 embryonic lethality at implantation, complete penetrance 0.00954529088428432 0.0832766595900406 1.6468592956962 0.476190476190476 6.1 6 1 abnormal circulating amino acid level 2.87526526873856e-05 0.000862225673894551 1.63819161519254 0.473684210526316 6.1 6 1 shiny skin 0.0143505955737676 0.104073196763111 1.63819161519254 0.473684210526316 6.1 6 1 decreased liver regeneration 0.0143505955737676 0.104073196763111 1.63819161519254 0.473684210526316 6.1 6 1 increased liver cholesterol level 0.0143505955737676 0.104073196763111 1.63819161519254 0.473684210526316 6.1 6 1 decreased circulating magnesium level 0.0143505955737676 0.104073196763111 1.63819161519254 0.473684210526316 6.1 6 1 abnormal angiogenesis 2.08572977491001e-06 0.00010173044735468 1.63573186802258 0.472972972972973 6.1 6 1 abnormal retinal blood vessel morphology 0.000892282991772884 0.0144596348015313 1.63313546823206 0.472222222222222 6.1 6 1 abnormal bone marrow cavity morphology 0.0216708269314073 0.137236332487984 1.62748448045271 0.470588235294118 6.1 6 1 abnormal dorsal-ventral axis patterning 0.0216708269314073 0.137236332487984 1.62748448045271 0.470588235294118 6.1 6 1 abnormal duodenum morphology 0.0216708269314073 0.137236332487984 1.62748448045271 0.470588235294118 6.1 6 1 abnormal testis development 0.0216708269314073 0.137236332487984 1.62748448045271 0.470588235294118 6.1 6 1 abnormal embryonic-extraembryonic boundary morphology 0.0216708269314073 0.137236332487984 1.62748448045271 0.470588235294118 6.1 6 1 abnormal ectoplacental cone morphology 0.0216708269314073 0.137236332487984 1.62748448045271 0.470588235294118 6.1 6 1 enhanced behavioral response to cocaine 0.0216708269314073 0.137236332487984 1.62748448045271 0.470588235294118 6.1 6 1 increased circulating magnesium level 0.0216708269314073 0.137236332487984 1.62748448045271 0.470588235294118 6.1 6 1 common atrium 0.0216708269314073 0.137236332487984 1.62748448045271 0.470588235294118 6.1 6 1 decreased body fat mass 0.0216708269314073 0.137236332487984 1.62748448045271 0.470588235294118 6.1 6 1 organ of Corti degeneration 0.000131483935507012 0.00311491704355898 1.62333273432911 0.469387755102041 6.1 6 1 abnormal myocardium layer morphology 1.45309278063587e-06 7.22913658366343e-05 1.61975907943791 0.468354430379747 6.1 6 1 abnormal hair cycle 0.00287605692611009 0.0348135844462231 1.61392210978228 0.466666666666667 6.1 6 1 decreased chondrocyte number 0.0329036394168624 0.181913574958076 1.61392210978228 0.466666666666667 6.1 6 1 decreased hepatocyte number 0.0329036394168624 0.181913574958076 1.61392210978228 0.466666666666667 6.1 6 1 abnormal pup retrieval 0.0329036394168624 0.181913574958076 1.61392210978228 0.466666666666667 6.1 6 1 no suckling reflex 0.0329036394168624 0.181913574958076 1.61392210978228 0.466666666666667 6.1 6 1 abnormal respiratory system morphology 0.0329036394168624 0.181913574958076 1.61392210978228 0.466666666666667 6.1 6 1 abnormal glial cell morphology 0.0329036394168624 0.181913574958076 1.61392210978228 0.466666666666667 6.1 6 1 abnormal pericyte morphology 0.0329036394168624 0.181913574958076 1.61392210978228 0.466666666666667 6.1 6 1 abnormal ear development 0.0329036394168624 0.181913574958076 1.61392210978228 0.466666666666667 6.1 6 1 spleen hyperplasia 3.06967839268224e-06 0.000137582432464812 1.61392210978228 0.466666666666667 6.1 6 1 abnormal ovarian follicle morphology 0.000282055031593573 0.005871229214134 1.61392210978228 0.466666666666667 6.1 6 1 increased circulating free fatty acid level 6.48796728636274e-06 0.000242689001877103 1.60742745340488 0.464788732394366 6.1 6 1 lymphoid hyperplasia 0.0042614771671789 0.0465584336546204 1.60568781330379 0.464285714285714 6.1 6 1 abnormal somite shape 0.0042614771671789 0.0465584336546204 1.60568781330379 0.464285714285714 6.1 6 1 failure of blastocyst to hatch from the zona pellucida 0.0042614771671789 0.0465584336546204 1.60568781330379 0.464285714285714 6.1 6 1 increased bone resorption 0.0042614771671789 0.0465584336546204 1.60568781330379 0.464285714285714 6.1 6 1 increased triglyceride level 0.0042614771671789 0.0465584336546204 1.60568781330379 0.464285714285714 6.1 6 1 lethality at weaning, incomplete penetrance 0.000606598349343202 0.0108554920431023 1.60267526581167 0.463414634146341 6.1 6 1 abnormal circulating hormone level 0.000890548154331129 0.0144596348015313 1.59618670198247 0.461538461538462 6.1 6 1 increased leukemia incidence 0.00632604337247345 0.0625291928096841 1.59618670198247 0.461538461538462 6.1 6 1 abnormal erythrocyte osmotic lysis 0.00632604337247345 0.0625291928096841 1.59618670198247 0.461538461538462 6.1 6 1 abnormal Mullerian duct morphology 0.00632604337247345 0.0625291928096841 1.59618670198247 0.461538461538462 6.1 6 1 abnormal membranous labyrinth morphology 0.0503015548082273 0.219141062154564 1.59618670198247 0.461538461538462 6.1 6 1 absent trabeculae carneae 0.0503015548082273 0.219141062154564 1.59618670198247 0.461538461538462 6.1 6 1 abnormal renal/urinary system morphology 0.0503015548082273 0.219141062154564 1.59618670198247 0.461538461538462 6.1 6 1 uterus hypoplasia 0.0503015548082273 0.219141062154564 1.59618670198247 0.461538461538462 6.1 6 1 abnormal lung interstitium morphology 0.0503015548082273 0.219141062154564 1.59618670198247 0.461538461538462 6.1 6 1 dystrophic cardiac calcinosis 0.0503015548082273 0.219141062154564 1.59618670198247 0.461538461538462 6.1 6 1 abnormal tail bud morphology 0.0503015548082273 0.219141062154564 1.59618670198247 0.461538461538462 6.1 6 1 abnormal otolith morphology 0.0503015548082273 0.219141062154564 1.59618670198247 0.461538461538462 6.1 6 1 abnormal bile duct development 0.0503015548082273 0.219141062154564 1.59618670198247 0.461538461538462 6.1 6 1 tracheoesophageal fistula 0.0503015548082273 0.219141062154564 1.59618670198247 0.461538461538462 6.1 6 1 small otic vesicle 0.0503015548082273 0.219141062154564 1.59618670198247 0.461538461538462 6.1 6 1 vestibular hair cell degeneration 0.0503015548082273 0.219141062154564 1.59618670198247 0.461538461538462 6.1 6 1 increased circulating thyroid-stimulating hormone level 0.0503015548082273 0.219141062154564 1.59618670198247 0.461538461538462 6.1 6 1 small pituitary gland 0.0503015548082273 0.219141062154564 1.59618670198247 0.461538461538462 6.1 6 1 increased circulating thyroxine level 0.0503015548082273 0.219141062154564 1.59618670198247 0.461538461538462 6.1 6 1 orthokeratosis 0.0503015548082273 0.219141062154564 1.59618670198247 0.461538461538462 6.1 6 1 abnormal hair follicle inner root sheath morphology 0.0503015548082273 0.219141062154564 1.59618670198247 0.461538461538462 6.1 6 1 decreased cardiac stroke volume 0.0503015548082273 0.219141062154564 1.59618670198247 0.461538461538462 6.1 6 1 absent hypoglossal nerve 0.0503015548082273 0.219141062154564 1.59618670198247 0.461538461538462 6.1 6 1 abnormal vitelline vasculature morphology 1.72484888432122e-08 1.99561004639491e-06 1.59387338792163 0.460869565217391 6.1 6 1 enlarged liver 1.58017018239973e-07 1.13932560252734e-05 1.59086607964253 0.46 6.1 6 1 cochlear outer hair cell degeneration 9.40855896580544e-06 0.000329630851090719 1.58510207210759 0.458333333333333 6.1 6 1 abnormal intestinal epithelium morphology 0.000280573051105747 0.00586491987080291 1.58510207210759 0.458333333333333 6.1 6 1 hemolytic anemia 0.00941077668060386 0.0827183992685586 1.58510207210759 0.458333333333333 6.1 6 1 abnormal liver development 0.00192421495842261 0.0268069157477291 1.58098492386835 0.457142857142857 6.1 6 1 abnormal facial morphology 8.94567527904906e-05 0.00225912357935376 1.57751785166689 0.456140350877193 6.1 6 1 decreased mean corpuscular hemoglobin 1.98205752078933e-05 0.000624097225691578 1.57662559043857 0.455882352941176 6.1 6 1 abnormal placenta labyrinth morphology 4.4383726141107e-06 0.000179519542725209 1.57598180702067 0.455696202531646 6.1 6 1 oxidative stress 1.00151960459209e-06 5.13665982767592e-05 1.5754953928827 0.455555555555556 6.1 6 1 decreased circulating total protein level 0.000130218417683471 0.00309969678457067 1.57200205498274 0.454545454545455 6.1 6 1 abnormal germ layer development 0.0140338197319049 0.104051047937745 1.57200205498274 0.454545454545455 6.1 6 1 abnormal circulating lipid level 0.0140338197319049 0.104051047937745 1.57200205498274 0.454545454545455 6.1 6 1 abnormal sphenoid bone morphology 0.0775820455195032 0.29188705364132 1.57200205498274 0.454545454545455 6.1 6 1 increased mast cell number 0.0775820455195032 0.29188705364132 1.57200205498274 0.454545454545455 6.1 6 1 abnormal awl hair morphology 0.0775820455195032 0.29188705364132 1.57200205498274 0.454545454545455 6.1 6 1 enlarged cranium 0.0775820455195032 0.29188705364132 1.57200205498274 0.454545454545455 6.1 6 1 abnormal stomach epithelium morphology 0.0775820455195032 0.29188705364132 1.57200205498274 0.454545454545455 6.1 6 1 abnormal large intestine morphology 0.0775820455195032 0.29188705364132 1.57200205498274 0.454545454545455 6.1 6 1 delayed hepatic development 0.0775820455195032 0.29188705364132 1.57200205498274 0.454545454545455 6.1 6 1 abnormal eye distance/ position 0.0775820455195032 0.29188705364132 1.57200205498274 0.454545454545455 6.1 6 1 abnormal food preference 0.0775820455195032 0.29188705364132 1.57200205498274 0.454545454545455 6.1 6 1 abnormal proximal-distal axis patterning 0.0775820455195032 0.29188705364132 1.57200205498274 0.454545454545455 6.1 6 1 vasculitis 0.0775820455195032 0.29188705364132 1.57200205498274 0.454545454545455 6.1 6 1 fatigue 0.0775820455195032 0.29188705364132 1.57200205498274 0.454545454545455 6.1 6 1 patent ductus arteriosus 0.0775820455195032 0.29188705364132 1.57200205498274 0.454545454545455 6.1 6 1 impaired luteinization 0.0775820455195032 0.29188705364132 1.57200205498274 0.454545454545455 6.1 6 1 abnormal lymph circulation 0.0775820455195032 0.29188705364132 1.57200205498274 0.454545454545455 6.1 6 1 abnormal coronal suture morphology 0.0775820455195032 0.29188705364132 1.57200205498274 0.454545454545455 6.1 6 1 pharyngeal arch hypoplasia 0.0775820455195032 0.29188705364132 1.57200205498274 0.454545454545455 6.1 6 1 abnormal spinal cord ventral horn morphology 0.0775820455195032 0.29188705364132 1.57200205498274 0.454545454545455 6.1 6 1 increased glycogen level 0.0775820455195032 0.29188705364132 1.57200205498274 0.454545454545455 6.1 6 1 abnormal palatal shelf elevation 0.0775820455195032 0.29188705364132 1.57200205498274 0.454545454545455 6.1 6 1 increased number of Howell-Jolly bodies 0.0775820455195032 0.29188705364132 1.57200205498274 0.454545454545455 6.1 6 1 hypolactation 0.0775820455195032 0.29188705364132 1.57200205498274 0.454545454545455 6.1 6 1 decreased colon length 0.0775820455195032 0.29188705364132 1.57200205498274 0.454545454545455 6.1 6 1 abnormal tail morphology 2.87697410786925e-05 0.000862225673894551 1.57200205498274 0.454545454545455 6.1 6 1 enlarged pericardium 0.00283242847211108 0.0344531336155321 1.57200205498274 0.454545454545455 6.1 6 1 abnormal axon morphology 1.07940940111746e-07 8.66138995251512e-06 1.5690909400661 0.453703703703704 6.1 6 1 atrioventricular septal defect 0.000189584958490505 0.00425729969755218 1.56606997175639 0.452830188679245 6.1 6 1 abnormal vibrissa morphology 0.000876547079128306 0.0143283657330109 1.56451633091139 0.452380952380952 6.1 6 1 decreased bone marrow cell number 1.34891048875906e-05 0.000453434437944346 1.56338834509242 0.452054794520548 6.1 6 1 hypoglycemia 9.89655216164025e-07 5.13665982767592e-05 1.56186010624091 0.451612903225806 6.1 6 1 abnormal eyelid morphology 0.00417368072492511 0.0462451260723885 1.56186010624091 0.451612903225806 6.1 6 1 decreased neuronal precursor cell number 0.00417368072492511 0.0462451260723885 1.56186010624091 0.451612903225806 6.1 6 1 cochlear inner hair cell degeneration 0.000276062699847908 0.00581954208365824 1.55967262710052 0.450980392156863 6.1 6 1 increased monocyte cell number 4.67775582517118e-07 2.86958998633231e-05 1.55628203443291 0.45 6.1 6 1 impaired ovarian folliculogenesis 0.00128253832530993 0.0196327020566674 1.55628203443291 0.45 6.1 6 1 abnormal vascular regression 0.0209869896452526 0.137236332487984 1.55628203443291 0.45 6.1 6 1 abnormal hair texture 0.0209869896452526 0.137236332487984 1.55628203443291 0.45 6.1 6 1 abnormal Peyer's patch T cell area morphology 0.0209869896452526 0.137236332487984 1.55628203443291 0.45 6.1 6 1 abnormal induced retinal neovascularization 0.0209869896452526 0.137236332487984 1.55628203443291 0.45 6.1 6 1 abnormal renal glomerulus morphology 1.53537743281836e-07 1.12705315047142e-05 1.55469561034072 0.44954128440367 6.1 6 1 decreased spleen weight 2.82937066441512e-05 0.000862225673894551 1.55377594420033 0.449275362318841 6.1 6 1 increased circulating alanine transaminase level 9.15713698165351e-06 0.00032309756371437 1.55184818248296 0.448717948717949 6.1 6 1 increased circulating triglyceride level 1.81614278942904e-09 2.82353449294046e-07 1.55031926801746 0.448275862068966 6.1 6 1 glomerulosclerosis 0.000127735359864542 0.00306996818998115 1.55031926801746 0.448275862068966 6.1 6 1 thrombocytosis 0.000127735359864542 0.00306996818998115 1.55031926801746 0.448275862068966 6.1 6 1 lordosis 0.0061571181760206 0.0620074148293573 1.55031926801746 0.448275862068966 6.1 6 1 decreased circulating cholesterol level 1.52194998373985e-11 5.04780077940384e-09 1.54966759955675 0.448087431693989 6.1 6 1 embryonic lethality during organogenesis, incomplete penetrance 4.2702137837379e-14 1.63417796723816e-11 1.54876376373516 0.447826086956522 6.1 6 1 decreased white adipose tissue amount 4.09721333841737e-05 0.00118461372439488 1.54853933774419 0.447761194029851 6.1 6 1 abnormal blood homeostasis 1.04690778212204e-07 8.58276584343856e-06 1.54718096990406 0.447368421052632 6.1 6 1 decreased birth body size 1.04690778212204e-07 8.58276584343856e-06 1.54718096990406 0.447368421052632 6.1 6 1 abnormal lung development 4.29921922806472e-06 0.00017531652180018 1.54611025643008 0.447058823529412 6.1 6 1 cardiac fibrosis 4.29921922806472e-06 0.00017531652180018 1.54611025643008 0.447058823529412 6.1 6 1 decreased hemoglobin content 3.75240589502567e-09 5.33377695078649e-07 1.5452445731958 0.446808510638298 6.1 6 1 increased respiratory quotient 0.00058563791053429 0.0106723392121175 1.5452445731958 0.446808510638298 6.1 6 1 reduced fertility 5.39192189532658e-09 7.45133650812493e-07 1.54259769999745 0.446043165467626 6.1 6 1 abnormal intestine morphology 1.9128447688234e-05 0.000606140300948815 1.54226147556414 0.445945945945946 6.1 6 1 abnormal pulmonary alveolus morphology 6.61024720600749e-07 3.73704316475991e-05 1.54087330141872 0.445544554455446 6.1 6 1 decreased circulating serum albumin level 9.5163770466688e-07 5.03659317097631e-05 1.53706867598312 0.444444444444444 6.1 6 1 abnormal myocardial trabeculae morphology 0.000853182729161564 0.0140549141641681 1.53706867598312 0.444444444444444 6.1 6 1 albuminuria 0.000853182729161564 0.0140549141641681 1.53706867598312 0.444444444444444 6.1 6 1 abnormal metabolism 0.000853182729161564 0.0140549141641681 1.53706867598312 0.444444444444444 6.1 6 1 abnormal epidermis stratum granulosum morphology 0.00274976053174239 0.0337779225812799 1.53706867598312 0.444444444444444 6.1 6 1 abnormal megakaryocyte differentiation 0.0314887584950638 0.177678837538583 1.53706867598312 0.444444444444444 6.1 6 1 abnormal heart shape 0.0314887584950638 0.177678837538583 1.53706867598312 0.444444444444444 6.1 6 1 underdeveloped hair follicles 0.0314887584950638 0.177678837538583 1.53706867598312 0.444444444444444 6.1 6 1 cortical renal glomerulopathies 0.0314887584950638 0.177678837538583 1.53706867598312 0.444444444444444 6.1 6 1 abnormal radius morphology 0.0314887584950638 0.177678837538583 1.53706867598312 0.444444444444444 6.1 6 1 abnormal thymus cortex morphology 0.0314887584950638 0.177678837538583 1.53706867598312 0.444444444444444 6.1 6 1 absent inner cell mass 0.0314887584950638 0.177678837538583 1.53706867598312 0.444444444444444 6.1 6 1 jerky movement 0.0314887584950638 0.177678837538583 1.53706867598312 0.444444444444444 6.1 6 1 decreased tumor latency 0.0314887584950638 0.177678837538583 1.53706867598312 0.444444444444444 6.1 6 1 abnormal aerobic respiration 0.0314887584950638 0.177678837538583 1.53706867598312 0.444444444444444 6.1 6 1 abnormal skin condition 0.000390675101128128 0.00777443451244974 1.5296789227332 0.442307692307692 6.1 6 1 abnormal homeostasis 0.0012431314308827 0.0192666008368892 1.52813223019252 0.441860465116279 6.1 6 1 delayed endochondral bone ossification 0.0012431314308827 0.0192666008368892 1.52813223019252 0.441860465116279 6.1 6 1 liver inflammation 9.99102066371902e-08 8.56988410379347e-06 1.52746199675823 0.441666666666667 6.1 6 1 enlarged liver sinusoidal spaces 0.00402940431349496 0.0453849631950504 1.52576670042442 0.441176470588235 6.1 6 1 abnormal endoderm development 0.00402940431349496 0.0453849631950504 1.52576670042442 0.441176470588235 6.1 6 1 abnormal skin physiology 0.00402940431349496 0.0453849631950504 1.52576670042442 0.441176470588235 6.1 6 1 increased body length 0.000567029214263383 0.010410787711145 1.52169798922329 0.44 6.1 6 1 abnormal inner ear vestibule morphology 0.0134519489797348 0.100532087274243 1.52169798922329 0.44 6.1 6 1 abnormal cochlear outer hair cell morphology 0.0134519489797348 0.100532087274243 1.52169798922329 0.44 6.1 6 1 double outlet right ventricle 6.26549973612429e-07 3.62451874269981e-05 1.51911226621696 0.439252336448598 6.1 6 1 sparse hair 1.25269824211539e-05 0.000429805086518902 1.51832393603211 0.439024390243902 6.1 6 1 hemopericardium 0.00181153482824041 0.0258976602600461 1.51832393603211 0.439024390243902 6.1 6 1 absent vitelline blood vessels 0.000260393143320142 0.00560803414726279 1.51684408814124 0.43859649122807 6.1 6 1 abnormal lipid homeostasis 4.58464043541563e-08 4.56171723323855e-06 1.51637736688335 0.438461538461538 6.1 6 1 seminiferous tubule degeneration 3.86834289135349e-05 0.00112543894061308 1.51601294069568 0.438356164383562 6.1 6 1 decreased circulating LDL cholesterol level 0.000120212985379834 0.00293166471698369 1.51305197792088 0.4375 6.1 6 1 abnormal osteoclast physiology 0.000120212985379834 0.00293166471698369 1.51305197792088 0.4375 6.1 6 1 small heart 0.00082291057897871 0.0138310139541185 1.51305197792088 0.4375 6.1 6 1 abnormal spongiotrophoblast layer morphology 0.00590768714135709 0.0597372835940071 1.51305197792088 0.4375 6.1 6 1 vasculature congestion 0.0474300393313098 0.219141062154564 1.51305197792088 0.4375 6.1 6 1 abnormal mouth morphology 0.0474300393313098 0.219141062154564 1.51305197792088 0.4375 6.1 6 1 poor circulation 0.0474300393313098 0.219141062154564 1.51305197792088 0.4375 6.1 6 1 disorganized yolk sac vascular plexus 0.0474300393313098 0.219141062154564 1.51305197792088 0.4375 6.1 6 1 increased intestinal adenocarcinoma incidence 0.0474300393313098 0.219141062154564 1.51305197792088 0.4375 6.1 6 1 abnormal pulmonary elastic fiber morphology 0.0474300393313098 0.219141062154564 1.51305197792088 0.4375 6.1 6 1 small epididymis 0.0474300393313098 0.219141062154564 1.51305197792088 0.4375 6.1 6 1 abnormal epididymis epithelium morphology 0.0474300393313098 0.219141062154564 1.51305197792088 0.4375 6.1 6 1 sepsis 0.0474300393313098 0.219141062154564 1.51305197792088 0.4375 6.1 6 1 dystonia 0.0474300393313098 0.219141062154564 1.51305197792088 0.4375 6.1 6 1 decreased creatinine clearance 0.0474300393313098 0.219141062154564 1.51305197792088 0.4375 6.1 6 1 increased heart left ventricle size 0.0474300393313098 0.219141062154564 1.51305197792088 0.4375 6.1 6 1 dilated respiratory conducting tubes 0.0474300393313098 0.219141062154564 1.51305197792088 0.4375 6.1 6 1 embryonic lethality between somite formation and embryo turning, incomplete penetrance 0.0474300393313098 0.219141062154564 1.51305197792088 0.4375 6.1 6 1 blistering 0.0199271843941602 0.133428993756322 1.5036541395487 0.434782608695652 6.1 6 1 conjunctivitis 0.0199271843941602 0.133428993756322 1.5036541395487 0.434782608695652 6.1 6 1 abnormal Wolffian duct morphology 0.0199271843941602 0.133428993756322 1.5036541395487 0.434782608695652 6.1 6 1 abnormal crista ampullaris morphology 0.0199271843941602 0.133428993756322 1.5036541395487 0.434782608695652 6.1 6 1 abnormal vertebral artery topology 0.0199271843941602 0.133428993756322 1.5036541395487 0.434782608695652 6.1 6 1 abnormal coat appearance 8.02684437138121e-05 0.00207221955392137 1.5036541395487 0.434782608695652 6.1 6 1 abnormal coat/ hair morphology 0.00054484421048364 0.0101141789072989 1.50081705626654 0.433962264150943 6.1 6 1 short tail 1.73701310779615e-05 0.000553951295595247 1.50003087656184 0.433734939759036 6.1 6 1 pale yolk sac 1.73701310779615e-05 0.000553951295595247 1.50003087656184 0.433734939759036 6.1 6 1 delayed eyelid opening 0.00866616501418743 0.0792539907087912 1.49864195908354 0.433333333333333 6.1 6 1 abnormal lactation 0.00866616501418743 0.0792539907087912 1.49864195908354 0.433333333333333 6.1 6 1 disorganized myocardium 0.00866616501418743 0.0792539907087912 1.49864195908354 0.433333333333333 6.1 6 1 decreased embryo size 1.41730047639828e-24 1.76276746752037e-21 1.49767727163 0.433054393305439 6.1 6 1 increased neuron apoptosis 2.49304331409669e-05 0.000780056005511385 1.49437232387248 0.432098765432099 6.1 6 1 abnormal circadian rhythm 0.00173240668870263 0.0252009452523263 1.4934019522336 0.431818181818182 6.1 6 1 increased heart weight 4.126144415962e-08 4.18929968763489e-06 1.4928364838685 0.431654676258993 6.1 6 1 small lung 0.000787762432095812 0.0133563293550296 1.49186077374832 0.431372549019608 6.1 6 1 increased oxygen consumption 1.66678196757647e-05 0.000538457161603438 1.48791822413482 0.430232558139535 6.1 6 1 dehydration 0.000110522945070534 0.0027355803568453 1.48217336612658 0.428571428571429 6.1 6 1 decreased glycogen level 0.00560829632979922 0.0576068652543371 1.48217336612658 0.428571428571429 6.1 6 1 myoclonus 0.01271937471038 0.0973521372063698 1.48217336612658 0.428571428571429 6.1 6 1 hypoxia 0.01271937471038 0.0973521372063698 1.48217336612658 0.428571428571429 6.1 6 1 decreased circulating progesterone level 0.01271937471038 0.0973521372063698 1.48217336612658 0.428571428571429 6.1 6 1 abnormal scapula morphology 0.0295682637159787 0.172655061017598 1.48217336612658 0.428571428571429 6.1 6 1 abnormal salivary gland morphology 0.0295682637159787 0.172655061017598 1.48217336612658 0.428571428571429 6.1 6 1 abnormal associative learning 0.0295682637159787 0.172655061017598 1.48217336612658 0.428571428571429 6.1 6 1 left pulmonary isomerism 0.0295682637159787 0.172655061017598 1.48217336612658 0.428571428571429 6.1 6 1 abnormal clavicle morphology 0.0295682637159787 0.172655061017598 1.48217336612658 0.428571428571429 6.1 6 1 absent segment of posterior cerebral artery 0.0295682637159787 0.172655061017598 1.48217336612658 0.428571428571429 6.1 6 1 abnormal zigzag hair morphology 0.0717758499678818 0.287045702242936 1.48217336612658 0.428571428571429 6.1 6 1 megacephaly 0.0717758499678818 0.287045702242936 1.48217336612658 0.428571428571429 6.1 6 1 translucent skin 0.0717758499678818 0.287045702242936 1.48217336612658 0.428571428571429 6.1 6 1 abnormal pinna reflex 0.0717758499678818 0.287045702242936 1.48217336612658 0.428571428571429 6.1 6 1 abnormal adrenal gland secretion 0.0717758499678818 0.287045702242936 1.48217336612658 0.428571428571429 6.1 6 1 increased lactate dehydrogenase level 0.0717758499678818 0.287045702242936 1.48217336612658 0.428571428571429 6.1 6 1 abnormal viscerocranium morphology 0.0717758499678818 0.287045702242936 1.48217336612658 0.428571428571429 6.1 6 1 sternebra fusion 0.0717758499678818 0.287045702242936 1.48217336612658 0.428571428571429 6.1 6 1 multiple persisting craniopharyngeal ducts 0.0717758499678818 0.287045702242936 1.48217336612658 0.428571428571429 6.1 6 1 abnormal vitelline vein topology 0.0717758499678818 0.287045702242936 1.48217336612658 0.428571428571429 6.1 6 1 increased fluid intake 0.00113855370979532 0.0178684691048318 1.48217336612658 0.428571428571429 6.1 6 1 lethality throughout fetal growth and development, complete penetrance 4.06919564632989e-10 7.23008869303258e-08 1.47437245367328 0.426315789473684 6.1 6 1 increased circulating alkaline phosphatase level 8.10956455109281e-09 1.09040766599153e-06 1.47302414781716 0.425925925925926 6.1 6 1 neurodegeneration 0.000749390451000268 0.0128559223921598 1.47302414781716 0.425925925925926 6.1 6 1 increased cellular sensitivity to gamma-irradiation 0.00164481384792943 0.0240674967454379 1.47166149828171 0.425531914893617 6.1 6 1 abnormal cell nucleus morphology 0.00164481384792943 0.0240674967454379 1.47166149828171 0.425531914893617 6.1 6 1 abnormal skin pigmentation 0.00364351270693486 0.0423515787780395 1.46982192140886 0.425 6.1 6 1 increased spleen weight 1.56274917759274e-06 7.69770015695434e-05 1.46905678766528 0.424778761061947 6.1 6 1 decreased hematocrit 5.16229456555835e-08 5.03576773797114e-06 1.46863753629894 0.424657534246575 6.1 6 1 abnormal liver morphology 1.73379326325311e-09 2.78245854344653e-07 1.46837286923527 0.424581005586592 6.1 6 1 extramedullary hematopoiesis 3.32837184938714e-06 0.000145251315357026 1.46819059852161 0.424528301886792 6.1 6 1 increased osteoblast cell number 0.00817366721343313 0.0755836326892748 1.46720191798389 0.424242424242424 6.1 6 1 head tossing 0.00817366721343313 0.0755836326892748 1.46720191798389 0.424242424242424 6.1 6 1 increased urine protein level 6.98696499829187e-05 0.00186882531540334 1.46317114348393 0.423076923076923 6.1 6 1 abnormal heart ventricle morphology 6.98696499829187e-05 0.00186882531540334 1.46317114348393 0.423076923076923 6.1 6 1 absent gastric milk in neonates 6.98696499829187e-05 0.00186882531540334 1.46317114348393 0.423076923076923 6.1 6 1 kinked neural tube 0.00107895980813878 0.0169867881186406 1.46317114348393 0.423076923076923 6.1 6 1 thick skin 0.0186776130917264 0.126941427775053 1.46317114348393 0.423076923076923 6.1 6 1 heart inflammation 0.0186776130917264 0.126941427775053 1.46317114348393 0.423076923076923 6.1 6 1 pulmonary edema 0.0186776130917264 0.126941427775053 1.46317114348393 0.423076923076923 6.1 6 1 abnormal ectoderm development 0.00237491650529032 0.03053025740005 1.46021524218396 0.422222222222222 6.1 6 1 cataract 9.9465946443662e-07 5.13665982767592e-05 1.45767463280217 0.421487603305785 6.1 6 1 abnormal cell morphology 2.11475182293382e-06 0.000102144566204813 1.45617032461559 0.421052631578947 6.1 6 1 persistence of hyaloid vascular system 0.00528091083208264 0.0550786821585139 1.45617032461559 0.421052631578947 6.1 6 1 abnormal reproductive system physiology 0.00528091083208264 0.0550786821585139 1.45617032461559 0.421052631578947 6.1 6 1 decreased neuron apoptosis 0.00528091083208264 0.0550786821585139 1.45617032461559 0.421052631578947 6.1 6 1 flaky skin 0.0439528769832791 0.21757767461872 1.45617032461559 0.421052631578947 6.1 6 1 thin dermal layer 0.0439528769832791 0.21757767461872 1.45617032461559 0.421052631578947 6.1 6 1 stereotypic behavior 0.0439528769832791 0.21757767461872 1.45617032461559 0.421052631578947 6.1 6 1 decreased germ cell number 0.0439528769832791 0.21757767461872 1.45617032461559 0.421052631578947 6.1 6 1 abnormal neural crest cell migration 0.0439528769832791 0.21757767461872 1.45617032461559 0.421052631578947 6.1 6 1 shortened RR interval 0.0439528769832791 0.21757767461872 1.45617032461559 0.421052631578947 6.1 6 1 abnormal interventricular septum morphology 0.00155241627552534 0.0229193431924297 1.45252989880405 0.42 6.1 6 1 abnormal digestive system physiology 0.00155241627552534 0.0229193431924297 1.45252989880405 0.42 6.1 6 1 abnormal circulating protein level 0.00155241627552534 0.0229193431924297 1.45252989880405 0.42 6.1 6 1 prenatal lethality 0.000466836891421645 0.00889851929050837 1.45029867008085 0.419354838709677 6.1 6 1 inner cell mass degeneration 0.0119107370008769 0.0925873696552543 1.45029867008085 0.419354838709677 6.1 6 1 abnormal mitochondrial ATP synthesis coupled electron transport 0.0119107370008769 0.0925873696552543 1.45029867008085 0.419354838709677 6.1 6 1 decreased total body fat amount 1.15345444281644e-15 6.37603983667977e-13 1.44963063752899 0.419161676646707 6.1 6 1 ventricular septal defect 2.97466435722658e-07 1.89730194579516e-05 1.4494783654032 0.419117647058824 6.1 6 1 spleen hypoplasia 6.39840364889545e-06 0.000241151955706476 1.44923618021266 0.419047619047619 6.1 6 1 increased granulocyte number 0.000142477275144715 0.00335935755376756 1.44879108310571 0.418918918918919 6.1 6 1 abnormal intestinal mucosa morphology 0.00342691947069257 0.0401824989081046 1.44770421807712 0.418604651162791 6.1 6 1 abnormal blood circulation 0.00342691947069257 0.0401824989081046 1.44770421807712 0.418604651162791 6.1 6 1 increased circulating calcium level 0.00101725272110465 0.0161687932507847 1.44624189058412 0.418181818181818 6.1 6 1 reduced female fertility 3.07076696555329e-11 8.04056087033031e-09 1.44597085574705 0.418103448275862 6.1 6 1 rib fusion 0.00030779768013031 0.00628323481385865 1.44530338189457 0.417910447761194 6.1 6 1 abnormal cell cycle 2.84393862533779e-06 0.000129803620743628 1.44350797396676 0.417391304347826 6.1 6 1 abnormal eye morphology 2.8172451904265e-07 1.82023309381452e-05 1.44307526773955 0.41726618705036 6.1 6 1 overriding aortic valve 0.00223188761146564 0.0300308819572382 1.44100188373417 0.416666666666667 6.1 6 1 abnormal uterus morphology 0.00765010761412554 0.0725053735090958 1.44100188373417 0.416666666666667 6.1 6 1 abnormal lysosome morphology 0.00765010761412554 0.0725053735090958 1.44100188373417 0.416666666666667 6.1 6 1 abnormal digestive system morphology 0.0274389041895576 0.162316942143935 1.44100188373417 0.416666666666667 6.1 6 1 abnormal adrenal gland morphology 0.0274389041895576 0.162316942143935 1.44100188373417 0.416666666666667 6.1 6 1 abnormal impulse conducting system conduction 0.0274389041895576 0.162316942143935 1.44100188373417 0.416666666666667 6.1 6 1 prolonged QT interval 0.0274389041895576 0.162316942143935 1.44100188373417 0.416666666666667 6.1 6 1 abnormal truncus arteriosus septation 0.0274389041895576 0.162316942143935 1.44100188373417 0.416666666666667 6.1 6 1 abnormal adipose tissue distribution 0.1092353000564 0.371713828851291 1.44100188373417 0.416666666666667 6.1 6 1 abnormal esophagus morphology 0.1092353000564 0.371713828851291 1.44100188373417 0.416666666666667 6.1 6 1 impaired embryo implantation 0.1092353000564 0.371713828851291 1.44100188373417 0.416666666666667 6.1 6 1 ear inflammation 0.1092353000564 0.371713828851291 1.44100188373417 0.416666666666667 6.1 6 1 increased papilloma incidence 0.1092353000564 0.371713828851291 1.44100188373417 0.416666666666667 6.1 6 1 loss of dopaminergic neurons 0.1092353000564 0.371713828851291 1.44100188373417 0.416666666666667 6.1 6 1 decreased circulating ketone body level 0.1092353000564 0.371713828851291 1.44100188373417 0.416666666666667 6.1 6 1 abnormal defecation 0.1092353000564 0.371713828851291 1.44100188373417 0.416666666666667 6.1 6 1 stria vascularis degeneration 0.1092353000564 0.371713828851291 1.44100188373417 0.416666666666667 6.1 6 1 hematuria 0.1092353000564 0.371713828851291 1.44100188373417 0.416666666666667 6.1 6 1 increased skeletal muscle glycogen level 0.1092353000564 0.371713828851291 1.44100188373417 0.416666666666667 6.1 6 1 increased type II pneumocyte number 0.1092353000564 0.371713828851291 1.44100188373417 0.416666666666667 6.1 6 1 prenatal growth retardation 0.1092353000564 0.371713828851291 1.44100188373417 0.416666666666667 6.1 6 1 abnormal vitelline vein connection 0.1092353000564 0.371713828851291 1.44100188373417 0.416666666666667 6.1 6 1 postnatal growth retardation 1.66483735541775e-26 2.76085528106777e-23 1.43535089595482 0.415032679738562 6.1 6 1 short humerus 0.00494116370434346 0.0527516940538813 1.43397260625254 0.414634146341463 6.1 6 1 increased bone trabecula number 0.00494116370434346 0.0527516940538813 1.43397260625254 0.414634146341463 6.1 6 1 thrombocytopenia 2.51349316311473e-07 1.64534585348629e-05 1.43106393970842 0.413793103448276 6.1 6 1 abnormal outer ear morphology 0.0173515557934571 0.119232030486808 1.43106393970842 0.413793103448276 6.1 6 1 enlarged epididymis 0.0173515557934571 0.119232030486808 1.43106393970842 0.413793103448276 6.1 6 1 polychromatophilia 0.0173515557934571 0.119232030486808 1.43106393970842 0.413793103448276 6.1 6 1 abnormal immune system morphology 0.00320586097277134 0.0382473821092025 1.42847143257127 0.41304347826087 6.1 6 1 abnormal sleep pattern 0.00320586097277134 0.0382473821092025 1.42847143257127 0.41304347826087 6.1 6 1 gliosis 0.000626815506343057 0.0110975343204865 1.42727805627004 0.412698412698413 6.1 6 1 increased circulating aspartate transaminase level 0.000626815506343057 0.0110975343204865 1.42727805627004 0.412698412698413 6.1 6 1 abnormal oocyte morphology 0.0110746512433898 0.0897404924855472 1.42404892039613 0.411764705882353 6.1 6 1 abnormal interatrial septum morphology 0.0654614880112417 0.267034357255855 1.42404892039613 0.411764705882353 6.1 6 1 enlarged sebaceous gland 0.0654614880112417 0.267034357255855 1.42404892039613 0.411764705882353 6.1 6 1 hyperlipidemia 0.0654614880112417 0.267034357255855 1.42404892039613 0.411764705882353 6.1 6 1 abnormal glutamate-mediated receptor currents 0.0654614880112417 0.267034357255855 1.42404892039613 0.411764705882353 6.1 6 1 abnormal involuntary movement 0.0654614880112417 0.267034357255855 1.42404892039613 0.411764705882353 6.1 6 1 increased brain size 0.0654614880112417 0.267034357255855 1.42404892039613 0.411764705882353 6.1 6 1 increased hepatoma incidence 0.0654614880112417 0.267034357255855 1.42404892039613 0.411764705882353 6.1 6 1 increased trabecular bone mass 0.0654614880112417 0.267034357255855 1.42404892039613 0.411764705882353 6.1 6 1 abnormal ductus venosus valve morphology 0.0654614880112417 0.267034357255855 1.42404892039613 0.411764705882353 6.1 6 1 perinatal lethality, incomplete penetrance 2.15434686774023e-10 4.12225987192601e-08 1.42314876305074 0.411504424778761 6.1 6 1 thin ventricular wall 5.53000131882855e-05 0.00156238592525638 1.42178852528439 0.411111111111111 6.1 6 1 impaired macrophage chemotaxis 0.00711799760588327 0.0690293140141701 1.41883262398442 0.41025641025641 6.1 6 1 osteoporosis 0.00460004370437794 0.0500770622084907 1.41480184948446 0.409090909090909 6.1 6 1 increased myocardial infarction size 0.0403228787818761 0.203042835971491 1.41480184948446 0.409090909090909 6.1 6 1 abnormal cochlear sensory epithelium morphology 0.0403228787818761 0.203042835971491 1.41480184948446 0.409090909090909 6.1 6 1 abnormal retinal layer morphology 0.0403228787818761 0.203042835971491 1.41480184948446 0.409090909090909 6.1 6 1 increased circulating creatine kinase level 0.0403228787818761 0.203042835971491 1.41480184948446 0.409090909090909 6.1 6 1 rough coat 0.0403228787818761 0.203042835971491 1.41480184948446 0.409090909090909 6.1 6 1 increased bone volume 0.0403228787818761 0.203042835971491 1.41480184948446 0.409090909090909 6.1 6 1 embryonic lethality during organogenesis, complete penetrance 5.17005887426584e-23 4.28684048324543e-20 1.41424042017911 0.408928571428571 6.1 6 1 abnormal long bone hypertrophic chondrocyte zone 0.00298591099192794 0.0358814183208732 1.41159368202531 0.408163265306122 6.1 6 1 decreased circulating creatinine level 0.00298591099192794 0.0358814183208732 1.41159368202531 0.408163265306122 6.1 6 1 abnormal enzyme/coenzyme activity 1.96390782735147e-07 1.3203299244694e-05 1.40979547351318 0.407643312101911 6.1 6 1 abnormal chondrocyte morphology 0.00194518524320205 0.0268069157477291 1.40897961965119 0.407407407407407 6.1 6 1 impaired limb coordination 0.00194518524320205 0.0268069157477291 1.40897961965119 0.407407407407407 6.1 6 1 axon degeneration 0.00194518524320205 0.0268069157477291 1.40897961965119 0.407407407407407 6.1 6 1 decreased platelet aggregation 0.00194518524320205 0.0268069157477291 1.40897961965119 0.407407407407407 6.1 6 1 abnormal heart valve morphology 0.0252659610764524 0.153456761391041 1.40897961965119 0.407407407407407 6.1 6 1 abnormal atrioventricular cushion morphology 0.0252659610764524 0.153456761391041 1.40897961965119 0.407407407407407 6.1 6 1 wrinkled skin 0.0252659610764524 0.153456761391041 1.40897961965119 0.407407407407407 6.1 6 1 abnormal eye muscle morphology 0.0252659610764524 0.153456761391041 1.40897961965119 0.407407407407407 6.1 6 1 edema 5.83959108742402e-08 5.28217557453354e-06 1.40749021201943 0.406976744186047 6.1 6 1 small spleen 7.31981435064304e-05 0.00193702534013027 1.40616447555599 0.406593406593407 6.1 6 1 abnormal vertebral body morphology 0.0160180869047589 0.11319599765792 1.40497683664082 0.40625 6.1 6 1 scoliosis 0.0160180869047589 0.11319599765792 1.40497683664082 0.40625 6.1 6 1 failure of primitive streak formation 0.0160180869047589 0.11319599765792 1.40497683664082 0.40625 6.1 6 1 increased circulating follicle stimulating hormone level 0.0160180869047589 0.11319599765792 1.40497683664082 0.40625 6.1 6 1 abnormal heart atrium morphology 0.0160180869047589 0.11319599765792 1.40497683664082 0.40625 6.1 6 1 decreased susceptibility to parasitic infection 0.0160180869047589 0.11319599765792 1.40497683664082 0.40625 6.1 6 1 bradykinesia 0.0160180869047589 0.11319599765792 1.40497683664082 0.40625 6.1 6 1 abnormal auditory brainstem response waveform shape 0.0160180869047589 0.11319599765792 1.40497683664082 0.40625 6.1 6 1 weight loss 5.47011268271031e-08 5.23342511470842e-06 1.40312411993316 0.405714285714286 6.1 6 1 increased white adipose tissue amount 0.0102425322492374 0.0866331759209257 1.40205588687649 0.405405405405405 6.1 6 1 malocclusion 0.0102425322492374 0.0866331759209257 1.40205588687649 0.405405405405405 6.1 6 1 abnormal branching of the mammary ductal tree 0.0102425322492374 0.0866331759209257 1.40205588687649 0.405405405405405 6.1 6 1 abnormal chromosome morphology 0.0102425322492374 0.0866331759209257 1.40205588687649 0.405405405405405 6.1 6 1 hunched posture 0.000236915677885478 0.00516954165561515 1.4008727173517 0.40506329113924 6.1 6 1 skin edema 0.00659246758804633 0.0643088750010402 1.39983040134177 0.404761904761905 6.1 6 1 abnormal pancreas morphology 0.00659246758804633 0.0643088750010402 1.39983040134177 0.404761904761905 6.1 6 1 decreased cardiac muscle contractility 2.99737469440368e-05 0.000887615422896328 1.39666336423466 0.403846153846154 6.1 6 1 decreased kidney weight 0.00277099645991089 0.0338715169239721 1.39666336423466 0.403846153846154 6.1 6 1 increased tumor incidence 5.82490111897405e-06 0.000226397523960124 1.39451795200081 0.403225806451613 6.1 6 1 decreased bone mineral density 5.05411440086817e-11 1.25721095721596e-08 1.39116272083811 0.402255639097744 6.1 6 1 decreased circulating glucose level 2.10925101570541e-11 6.17266106066731e-09 1.38832009443637 0.401433691756272 6.1 6 1 decreased erythrocyte cell number 4.72977645988441e-07 2.86958998633231e-05 1.38776741923954 0.401273885350318 6.1 6 1 delayed bone ossification 0.000471910069633352 0.00892681595599211 1.38336180838481 0.4 6.1 6 1 thick pulmonary interalveolar septum 0.0147188878524502 0.105818594025925 1.38336180838481 0.4 6.1 6 1 abnormal dermal layer morphology 0.0147188878524502 0.105818594025925 1.38336180838481 0.4 6.1 6 1 increased circulating serum albumin level 0.0147188878524502 0.105818594025925 1.38336180838481 0.4 6.1 6 1 impaired adaptive thermogenesis 0.0147188878524502 0.105818594025925 1.38336180838481 0.4 6.1 6 1 gastrointestinal hemorrhage 0.0231418163129702 0.145000675260739 1.38336180838481 0.4 6.1 6 1 abnormal response to new environment 0.0231418163129702 0.145000675260739 1.38336180838481 0.4 6.1 6 1 salivary gland inflammation 0.0231418163129702 0.145000675260739 1.38336180838481 0.4 6.1 6 1 abnormal spleen marginal zone morphology 0.0231418163129702 0.145000675260739 1.38336180838481 0.4 6.1 6 1 interdigital webbing 0.0976906570018946 0.342261280693257 1.38336180838481 0.4 6.1 6 1 hyperpigmentation 0.0976906570018946 0.342261280693257 1.38336180838481 0.4 6.1 6 1 abnormal epidermis stratum spinosum morphology 0.0976906570018946 0.342261280693257 1.38336180838481 0.4 6.1 6 1 abnormal cricoid cartilage morphology 0.0976906570018946 0.342261280693257 1.38336180838481 0.4 6.1 6 1 dilated ureter 0.0976906570018946 0.342261280693257 1.38336180838481 0.4 6.1 6 1 abnormal trophectoderm morphology 0.0976906570018946 0.342261280693257 1.38336180838481 0.4 6.1 6 1 abnormal aorta wall morphology 0.0976906570018946 0.342261280693257 1.38336180838481 0.4 6.1 6 1 abnormal microglial cell activation 0.0976906570018946 0.342261280693257 1.38336180838481 0.4 6.1 6 1 decreased cell proliferation 5.82036863048292e-08 5.28217557453354e-06 1.38336180838481 0.4 6.1 6 1 embryonic lethality before implantation, complete penetrance 7.6065616061552e-06 0.000278254735225163 1.38336180838481 0.4 6.1 6 1 decreased heart rate 5.91749241991006e-05 0.00163552915494736 1.38336180838481 0.4 6.1 6 1 alopecia 8.94183264146201e-05 0.00225912357935376 1.38336180838481 0.4 6.1 6 1 abnormal retinal pigment epithelium morphology 0.00031068859582095 0.00628323481385865 1.38336180838481 0.4 6.1 6 1 abnormal head morphology 0.00256380692460034 0.0322057854301648 1.38336180838481 0.4 6.1 6 1 abnormal platelet physiology 0.00256380692460034 0.0322057854301648 1.38336180838481 0.4 6.1 6 1 abnormal thyroid gland morphology 0.0367635409961061 0.191715560094796 1.38336180838481 0.4 6.1 6 1 decreased placenta weight 0.0367635409961061 0.191715560094796 1.38336180838481 0.4 6.1 6 1 abnormal energy expenditure 0.0367635409961061 0.191715560094796 1.38336180838481 0.4 6.1 6 1 decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 0.0367635409961061 0.191715560094796 1.38336180838481 0.4 6.1 6 1 abnormal pericardium morphology 0.0592634685419635 0.246931118924848 1.38336180838481 0.4 6.1 6 1 abnormal fibula morphology 0.0592634685419635 0.246931118924848 1.38336180838481 0.4 6.1 6 1 abnormal hyoid bone morphology 0.0592634685419635 0.246931118924848 1.38336180838481 0.4 6.1 6 1 abnormal male reproductive system physiology 0.0592634685419635 0.246931118924848 1.38336180838481 0.4 6.1 6 1 abnormal heart right ventricle morphology 0.0592634685419635 0.246931118924848 1.38336180838481 0.4 6.1 6 1 kidney atrophy 0.0592634685419635 0.246931118924848 1.38336180838481 0.4 6.1 6 1 decreased circulating VLDL cholesterol level 0.0592634685419635 0.246931118924848 1.38336180838481 0.4 6.1 6 1 abnormal response to tactile stimuli 0.0592634685419635 0.246931118924848 1.38336180838481 0.4 6.1 6 1 increased urine calcium level 0.0592634685419635 0.246931118924848 1.38336180838481 0.4 6.1 6 1 absent ductus venosus valve 0.0592634685419635 0.246931118924848 1.38336180838481 0.4 6.1 6 1 enlarged spleen 1.70942616977394e-11 5.31524699664083e-09 1.38096013857858 0.399305555555556 6.1 6 1 thymus hypoplasia 3.12851617163873e-06 0.000138967571016988 1.37834962791964 0.398550724637681 6.1 6 1 decreased circulating HDL cholesterol level 7.07262509656099e-06 0.000260639332262155 1.3779580513208 0.3984375 6.1 6 1 cardiac hypertrophy 8.29952775206729e-05 0.00211744361879666 1.37630383997468 0.397959183673469 6.1 6 1 decreased body length 7.41387710070497e-11 1.67654720800033e-08 1.37578865979876 0.397810218978102 6.1 6 1 increased liver weight 0.000189973976453585 0.00425729969755218 1.37550179810989 0.397727272727273 6.1 6 1 abnormal brain morphology 5.72211537205867e-07 3.34912046776375e-05 1.37476949901596 0.397515527950311 6.1 6 1 abnormal spermatogenesis 1.05235922904473e-07 8.58276584343856e-06 1.37208440233819 0.396739130434783 6.1 6 1 cochlear ganglion degeneration 0.00236610640501873 0.0304958014636481 1.3714362755539 0.396551724137931 6.1 6 1 abnormal embryonic neuroepithelium morphology 0.00236610640501873 0.0304958014636481 1.3714362755539 0.396551724137931 6.1 6 1 abnormal enzyme/coenzyme level 0.00236610640501873 0.0304958014636481 1.3714362755539 0.396551724137931 6.1 6 1 abnormal mesoderm development 0.00363264409518004 0.0423241320222967 1.37031122528684 0.39622641509434 6.1 6 1 preweaning lethality, incomplete penetrance 3.26740682487004e-15 1.62553489537284e-12 1.36983259754486 0.396088019559902 6.1 6 1 curly tail 0.00559727575857246 0.0576068652543371 1.36895178954747 0.395833333333333 6.1 6 1 abnormal glucose homeostasis 1.4644943455194e-07 1.10391808620591e-05 1.36816003027069 0.395604395604396 6.1 6 1 small ovary 0.000175888502379266 0.00403246681722049 1.36816003027069 0.395604395604396 6.1 6 1 increased circulating creatinine level 0.00026644098413259 0.00568902959682246 1.36727620596173 0.395348837209302 6.1 6 1 abnormal vasculogenesis 0.00866224904939296 0.0792539907087912 1.36727620596173 0.395348837209302 6.1 6 1 incomplete somite formation 0.0134783723039035 0.100532087274243 1.36515967932711 0.394736842105263 6.1 6 1 abnormal embryonic tissue morphology 2.50192634724412e-06 0.000118021773324305 1.36454055929114 0.394557823129252 6.1 6 1 corneal opacity 0.000934578595496559 0.0149638059221513 1.36387783925263 0.394366197183099 6.1 6 1 increased mean corpuscular hemoglobin 0.000107543321450291 0.00267514012107598 1.36240178098504 0.393939393939394 6.1 6 1 abnormal tooth development 0.0211169597041207 0.137236332487984 1.36240178098504 0.393939393939394 6.1 6 1 abnormal epidermis stratum basale morphology 0.0211169597041207 0.137236332487984 1.36240178098504 0.393939393939394 6.1 6 1 diarrhea 0.0211169597041207 0.137236332487984 1.36240178098504 0.393939393939394 6.1 6 1 anemia 2.32343157043536e-08 2.56868268064798e-06 1.36041504853008 0.393364928909953 6.1 6 1 increased B cell number 2.89518746743418e-05 0.000862488482064972 1.35971459798507 0.393162393162393 6.1 6 1 increased leukocyte cell number 3.4805704504711e-06 0.000149274465440463 1.359510742723 0.393103448275862 6.1 6 1 increased food intake 0.000373129335575777 0.00745509415457626 1.35865891894936 0.392857142857143 6.1 6 1 abnormal stria vascularis morphology 0.0333843404897936 0.181913574958076 1.35865891894936 0.392857142857143 6.1 6 1 abnormal circulating cholesterol level 0.0333843404897936 0.181913574958076 1.35865891894936 0.392857142857143 6.1 6 1 abnormal jaw morphology 0.0333843404897936 0.181913574958076 1.35865891894936 0.392857142857143 6.1 6 1 small superior cervical ganglion 0.0333843404897936 0.181913574958076 1.35865891894936 0.392857142857143 6.1 6 1 reddish skin 0.0333843404897936 0.181913574958076 1.35865891894936 0.392857142857143 6.1 6 1 abnormal spleen germinal center morphology 0.0333843404897936 0.181913574958076 1.35865891894936 0.392857142857143 6.1 6 1 straub tail 0.0333843404897936 0.181913574958076 1.35865891894936 0.392857142857143 6.1 6 1 abnormal brainstem morphology 0.0333843404897936 0.181913574958076 1.35865891894936 0.392857142857143 6.1 6 1 corneal vascularization 0.0333843404897936 0.181913574958076 1.35865891894936 0.392857142857143 6.1 6 1 subcutaneous edema 0.0333843404897936 0.181913574958076 1.35865891894936 0.392857142857143 6.1 6 1 abnormal heart development 1.42983081526113e-06 7.18526091507487e-05 1.35709544493446 0.392405063291139 6.1 6 1 increased kidney weight 0.00513763876217721 0.053979770240584 1.35623706704393 0.392156862745098 6.1 6 1 prenatal lethality, complete penetrance 2.04418037117505e-10 4.06791893863835e-08 1.35599313951389 0.392086330935252 6.1 6 1 embryonic lethality between implantation and somite formation, complete penetrance 2.46552215213079e-09 3.71696142631838e-07 1.3551299347443 0.391836734693878 6.1 6 1 postnatal lethality 8.82121997126501e-07 4.74952813108021e-05 1.35419454134055 0.391566265060241 6.1 6 1 delayed wound healing 0.00793334810703051 0.0737727230513585 1.35328872559383 0.391304347826087 6.1 6 1 atrial septal defect 0.00793334810703051 0.0737727230513585 1.35328872559383 0.391304347826087 6.1 6 1 fragile skeleton 0.0534343966025506 0.226820653958056 1.35328872559383 0.391304347826087 6.1 6 1 abnormal circulating insulin level 0.0534343966025506 0.226820653958056 1.35328872559383 0.391304347826087 6.1 6 1 failure of embryo implantation 0.0534343966025506 0.226820653958056 1.35328872559383 0.391304347826087 6.1 6 1 pancreas inflammation 0.0534343966025506 0.226820653958056 1.35328872559383 0.391304347826087 6.1 6 1 abnormal ulna morphology 0.0534343966025506 0.226820653958056 1.35328872559383 0.391304347826087 6.1 6 1 increased lymphocyte cell number 0.00131194811718657 0.0197786117666764 1.35328872559383 0.391304347826087 6.1 6 1 female infertility 6.32259725940384e-10 1.04849737885114e-07 1.35215815857162 0.390977443609023 6.1 6 1 decreased lymphocyte cell number 1.64249396696112e-05 0.000534078920629515 1.35093926600079 0.390625 6.1 6 1 abnormal tooth morphology 0.00200296575533885 0.0274511146909388 1.35093926600079 0.390625 6.1 6 1 abnormal response/metabolism to endogenous compounds 0.000521701783241938 0.00983131201374485 1.34962127647298 0.390243902439024 6.1 6 1 abnormal mammary gland development 0.0123099414590523 0.0946552685607192 1.34962127647298 0.390243902439024 6.1 6 1 Leydig cell hyperplasia 0.0123099414590523 0.0946552685607192 1.34962127647298 0.390243902439024 6.1 6 1 liver fibrosis 0.0123099414590523 0.0946552685607192 1.34962127647298 0.390243902439024 6.1 6 1 short ulna 0.0123099414590523 0.0946552685607192 1.34962127647298 0.390243902439024 6.1 6 1 abnormal cholesterol homeostasis 0.0123099414590523 0.0946552685607192 1.34962127647298 0.390243902439024 6.1 6 1 palatal shelves fail to meet at midline 0.0123099414590523 0.0946552685607192 1.34962127647298 0.390243902439024 6.1 6 1 perinatal lethality, complete penetrance 3.81941319922699e-08 3.95866263878214e-06 1.34764119830914 0.389671361502347 6.1 6 1 hydrops fetalis 0.00120573321422297 0.0188041465227564 1.34493509148523 0.388888888888889 6.1 6 1 abnormal maxilla morphology 0.00470648154643874 0.0504628139946826 1.34493509148523 0.388888888888889 6.1 6 1 decreased tumor growth/size 0.00470648154643874 0.0504628139946826 1.34493509148523 0.388888888888889 6.1 6 1 abnormal cell adhesion 0.00470648154643874 0.0504628139946826 1.34493509148523 0.388888888888889 6.1 6 1 abnormal long bone epiphyseal plate proliferative zone 0.00470648154643874 0.0504628139946826 1.34493509148523 0.388888888888889 6.1 6 1 impaired wound healing 0.019217202549566 0.129898889516428 1.34493509148523 0.388888888888889 6.1 6 1 renal hypoplasia 0.019217202549566 0.129898889516428 1.34493509148523 0.388888888888889 6.1 6 1 head tilt 0.019217202549566 0.129898889516428 1.34493509148523 0.388888888888889 6.1 6 1 narrow eye opening 0.019217202549566 0.129898889516428 1.34493509148523 0.388888888888889 6.1 6 1 delayed kidney development 0.0870804977033552 0.308565153898997 1.34493509148523 0.388888888888889 6.1 6 1 right pulmonary isomerism 0.0870804977033552 0.308565153898997 1.34493509148523 0.388888888888889 6.1 6 1 abnormal retinal rod cell morphology 0.0870804977033552 0.308565153898997 1.34493509148523 0.388888888888889 6.1 6 1 abnormal phrenic nerve morphology 0.0870804977033552 0.308565153898997 1.34493509148523 0.388888888888889 6.1 6 1 eye inflammation 0.0870804977033552 0.308565153898997 1.34493509148523 0.388888888888889 6.1 6 1 abnormal thyroid cartilage morphology 0.0870804977033552 0.308565153898997 1.34493509148523 0.388888888888889 6.1 6 1 abnormal Peyer's patch follicle morphology 0.0870804977033552 0.308565153898997 1.34493509148523 0.388888888888889 6.1 6 1 abnormal white adipose tissue morphology 0.0870804977033552 0.308565153898997 1.34493509148523 0.388888888888889 6.1 6 1 increased circulating renin level 0.0870804977033552 0.308565153898997 1.34493509148523 0.388888888888889 6.1 6 1 abnormal body wall morphology 0.0870804977033552 0.308565153898997 1.34493509148523 0.388888888888889 6.1 6 1 decreased activity of thyroid 0.0870804977033552 0.308565153898997 1.34493509148523 0.388888888888889 6.1 6 1 decreased pulmonary respiratory rate 0.0870804977033552 0.308565153898997 1.34493509148523 0.388888888888889 6.1 6 1 increased gastrointestinal tumor incidence 0.0870804977033552 0.308565153898997 1.34493509148523 0.388888888888889 6.1 6 1 increased effector memory CD4-positive, alpha-beta T cell number 0.0870804977033552 0.308565153898997 1.34493509148523 0.388888888888889 6.1 6 1 increased effector memory CD8-positive, alpha-beta T cell number 0.0870804977033552 0.308565153898997 1.34493509148523 0.388888888888889 6.1 6 1 abnormal bone structure 1.91483588576467e-07 1.30497377146291e-05 1.34393958068472 0.38860103626943 6.1 6 1 pallor 6.96234838603642e-07 3.89187451916081e-05 1.3438371852881 0.388571428571429 6.1 6 1 enlarged heart 1.34687888810697e-08 1.63432255325175e-06 1.34162244347665 0.387931034482759 6.1 6 1 increased sarcoma incidence 0.00725114011078064 0.0701837004885869 1.34101399792405 0.387755102040816 6.1 6 1 hemorrhage 1.24337542473459e-08 1.54644818451365e-06 1.33921196343636 0.387234042553191 6.1 6 1 absent mature ovarian follicles 0.0302351295627135 0.17612382509949 1.33873723392078 0.387096774193548 6.1 6 1 abnormal astrocyte morphology 0.0112199338962544 0.0897404924855472 1.33620174673533 0.386363636363636 6.1 6 1 cochlear hair cell degeneration 0.0112199338962544 0.0897404924855472 1.33620174673533 0.386363636363636 6.1 6 1 decreased sensitivity to induced morbidity/mortality 0.0112199338962544 0.0897404924855472 1.33620174673533 0.386363636363636 6.1 6 1 embryonic lethality, incomplete penetrance 0.0112199338962544 0.0897404924855472 1.33620174673533 0.386363636363636 6.1 6 1 increased blood urea nitrogen level 7.90720603918277e-06 0.000285060507571988 1.33565967706119 0.386206896551724 6.1 6 1 embryonic lethality between somite formation and embryo turning, complete penetrance 0.00168486092009184 0.0245811820453282 1.33395602951392 0.385714285714286 6.1 6 1 abnormal urine homeostasis 0.000267662213997472 0.00569068168648471 1.33292674245411 0.385416666666667 6.1 6 1 prenatal lethality, incomplete penetrance 1.76256387077834e-10 3.81250228570533e-08 1.33103068734393 0.384868421052632 6.1 6 1 increased insulin sensitivity 1.09226323737769e-05 0.000377361778191251 1.33015558498539 0.384615384615385 6.1 6 1 increased grip strength 0.000404771517732592 0.00795869105305736 1.33015558498539 0.384615384615385 6.1 6 1 neonatal lethality, incomplete penetrance 3.71630300149383e-09 5.33377695078649e-07 1.33015558498539 0.384615384615385 6.1 6 1 abnormal hair growth 0.00661679020109365 0.0644198263218022 1.33015558498539 0.384615384615385 6.1 6 1 acanthosis 0.0174536064901661 0.119602881940188 1.33015558498539 0.384615384615385 6.1 6 1 failure of heart looping 0.0174536064901661 0.119602881940188 1.33015558498539 0.384615384615385 6.1 6 1 abnormal leukocyte cell number 0.0480672459363434 0.219141062154564 1.33015558498539 0.384615384615385 6.1 6 1 decreased circulating glycerol level 0.0480672459363434 0.219141062154564 1.33015558498539 0.384615384615385 6.1 6 1 decreased Peyer's patch number 0.0480672459363434 0.219141062154564 1.33015558498539 0.384615384615385 6.1 6 1 pup cannibalization 0.146068890836507 0.424470053686696 1.33015558498539 0.384615384615385 6.1 6 1 increased pituitary adenoma incidence 0.146068890836507 0.424470053686696 1.33015558498539 0.384615384615385 6.1 6 1 anal atresia 0.146068890836507 0.424470053686696 1.33015558498539 0.384615384615385 6.1 6 1 muscle fatigue 0.146068890836507 0.424470053686696 1.33015558498539 0.384615384615385 6.1 6 1 abnormal vestibulocochlear ganglion morphology 0.146068890836507 0.424470053686696 1.33015558498539 0.384615384615385 6.1 6 1 abnormal retinal inner plexiform layer morphology 0.146068890836507 0.424470053686696 1.33015558498539 0.384615384615385 6.1 6 1 small interparietal bone 0.146068890836507 0.424470053686696 1.33015558498539 0.384615384615385 6.1 6 1 decreased luteinizing hormone level 0.146068890836507 0.424470053686696 1.33015558498539 0.384615384615385 6.1 6 1 abnormal aorta tunica media morphology 0.146068890836507 0.424470053686696 1.33015558498539 0.384615384615385 6.1 6 1 deafness 0.000245702908926746 0.00531466074743721 1.32746840198542 0.383838383838384 6.1 6 1 decreased grip strength 7.25032122443407e-08 6.44113358777848e-06 1.32651132310872 0.383561643835616 6.1 6 1 absent mesoderm 0.00393145920491578 0.0448666821749434 1.32572173303544 0.383333333333333 6.1 6 1 abnormal long bone epiphyseal plate morphology 0.00393145920491578 0.0448666821749434 1.32572173303544 0.383333333333333 6.1 6 1 decreased body weight 9.11200679601299e-38 4.53322338101646e-34 1.32413872611955 0.382875605815832 6.1 6 1 decreased heart weight 0.000929065702936737 0.0149638059221513 1.32358691542991 0.382716049382716 6.1 6 1 kinked tail 0.000225357158941932 0.00496084896343413 1.32233114036783 0.382352941176471 6.1 6 1 decreased circulating alanine transaminase level 0.0023494966506556 0.0304958014636481 1.32233114036783 0.382352941176471 6.1 6 1 thin skin 0.027333626846478 0.162316942143935 1.32233114036783 0.382352941176471 6.1 6 1 increased width of hypertrophic chondrocyte zone 0.027333626846478 0.162316942143935 1.32233114036783 0.382352941176471 6.1 6 1 abnormal nervous system development 0.027333626846478 0.162316942143935 1.32233114036783 0.382352941176471 6.1 6 1 decreased rib number 0.000561395911405481 0.0103826939005289 1.32118824396302 0.382022471910112 6.1 6 1 hydronephrosis 0.000850050455572524 0.0140549141641681 1.31748743655696 0.380952380952381 6.1 6 1 spina bifida 0.015828386918133 0.113141127755333 1.31748743655696 0.380952380952381 6.1 6 1 liver degeneration 0.0775374407425696 0.29188705364132 1.31748743655696 0.380952380952381 6.1 6 1 abnormal erythrocyte physiology 0.0775374407425696 0.29188705364132 1.31748743655696 0.380952380952381 6.1 6 1 vascular ring 0.0775374407425696 0.29188705364132 1.31748743655696 0.380952380952381 6.1 6 1 abnormal bone mineralization 7.65784942805035e-05 0.00199464926201835 1.31476535507647 0.380165289256198 6.1 6 1 kidney inflammation 0.00927958377262268 0.0827183992685586 1.31419371796557 0.38 6.1 6 1 decreased circulating alkaline phosphatase level 0.00927958377262268 0.0827183992685586 1.31419371796557 0.38 6.1 6 1 abnormal axon extension 0.00927958377262268 0.0827183992685586 1.31419371796557 0.38 6.1 6 1 decreased respiratory quotient 0.00927958377262268 0.0827183992685586 1.31419371796557 0.38 6.1 6 1 abnormal somite development 0.00128884040712992 0.0196686534523661 1.31331817251722 0.379746835443038 6.1 6 1 decreased granulocyte number 0.0431821533597769 0.215477645902598 1.31180861139939 0.379310344827586 6.1 6 1 abnormal spinal nerve morphology 0.0431821533597769 0.215477645902598 1.31180861139939 0.379310344827586 6.1 6 1 decreased retinal photoreceptor cell number 0.0431821533597769 0.215477645902598 1.31180861139939 0.379310344827586 6.1 6 1 increased mortality induced by gamma-irradiation 0.0431821533597769 0.215477645902598 1.31180861139939 0.379310344827586 6.1 6 1 increased susceptibility to induced arthritis 0.0431821533597769 0.215477645902598 1.31180861139939 0.379310344827586 6.1 6 1 blood in lymph vessels 0.0431821533597769 0.215477645902598 1.31180861139939 0.379310344827586 6.1 6 1 impaired righting response 0.000469984191624197 0.00892431814248237 1.31055329215403 0.378947368421053 6.1 6 1 abnormal vascular development 0.00326890454661749 0.0389062203813923 1.31000171248561 0.378787878787879 6.1 6 1 decreased body size 1.91593339267839e-23 1.906353725715e-20 1.3088197560533 0.378446115288221 6.1 6 1 small seminiferous tubules 0.00195707360898216 0.0268962464217853 1.30858549441806 0.378378378378378 6.1 6 1 increased brown adipose tissue amount 0.0246800453410702 0.153456761391041 1.30858549441806 0.378378378378378 6.1 6 1 abnormal hair follicle development 0.0246800453410702 0.153456761391041 1.30858549441806 0.378378378378378 6.1 6 1 abnormal calcium ion homeostasis 0.0246800453410702 0.153456761391041 1.30858549441806 0.378378378378378 6.1 6 1 abnormal respiratory electron transport chain 0.0246800453410702 0.153456761391041 1.30858549441806 0.378378378378378 6.1 6 1 trabecula carnea hypoplasia 0.0143385062178819 0.104073196763111 1.30650837458565 0.377777777777778 6.1 6 1 increased circulating corticosterone level 0.0143385062178819 0.104073196763111 1.30650837458565 0.377777777777778 6.1 6 1 abnormal cell migration 0.0143385062178819 0.104073196763111 1.30650837458565 0.377777777777778 6.1 6 1 respiratory failure 1.46726123608523e-05 0.000483418850961854 1.30549044831017 0.377483443708609 6.1 6 1 abnormal placenta development 0.00842536359861703 0.077622562783555 1.30505830979699 0.377358490566038 6.1 6 1 enlarged kidney 0.00842536359861703 0.077622562783555 1.30505830979699 0.377358490566038 6.1 6 1 abnormal maternal nurturing 0.00499217611902904 0.053182176000363 1.30398858987093 0.377049180327869 6.1 6 1 abnormal epidermal layer morphology 0.00297685157786942 0.0358814183208732 1.30316692094221 0.376811594202899 6.1 6 1 circling 0.00107352838722824 0.016954932464954 1.30198758436217 0.376470588235294 6.1 6 1 respiratory distress 4.62114776556492e-06 0.000185404920432947 1.29940054255798 0.375722543352601 6.1 6 1 increased sensitivity to induced morbidity/mortality 2.59593443116379e-06 0.000120630312661246 1.29690169536076 0.375 6.1 6 1 hyperglycemia 0.000978814292067971 0.015607695843071 1.29690169536076 0.375 6.1 6 1 abnormal neuromuscular synapse morphology 0.00270897837139762 0.0335252920340874 1.29690169536076 0.375 6.1 6 1 abnormal digit morphology 0.00270897837139762 0.0335252920340874 1.29690169536076 0.375 6.1 6 1 abnormal forebrain development 0.00270897837139762 0.0335252920340874 1.29690169536076 0.375 6.1 6 1 abnormal heart left ventricle morphology 0.00270897837139762 0.0335252920340874 1.29690169536076 0.375 6.1 6 1 abnormal osteoclast morphology 0.0129778987061952 0.0990261442688978 1.29690169536076 0.375 6.1 6 1 decreased body height 0.0690316920503462 0.278760282427332 1.29690169536076 0.375 6.1 6 1 abnormal body weight 0.0690316920503462 0.278760282427332 1.29690169536076 0.375 6.1 6 1 abnormal nursing 0.0690316920503462 0.278760282427332 1.29690169536076 0.375 6.1 6 1 abnormal cardiac muscle contractility 0.0690316920503462 0.278760282427332 1.29690169536076 0.375 6.1 6 1 abnormal inner cell mass apoptosis 0.0690316920503462 0.278760282427332 1.29690169536076 0.375 6.1 6 1 head bobbing 0.0222651778611566 0.140570126724942 1.29690169536076 0.375 6.1 6 1 abnormal pancreatic beta cell morphology 0.0222651778611566 0.140570126724942 1.29690169536076 0.375 6.1 6 1 neonatal lethality 0.0387653551574862 0.19719595287167 1.29690169536076 0.375 6.1 6 1 pancreatic islet hyperplasia 0.0387653551574862 0.19719595287167 1.29690169536076 0.375 6.1 6 1 absent mandible 0.127847027604246 0.387523951491176 1.29690169536076 0.375 6.1 6 1 intraventricular hemorrhage 0.127847027604246 0.387523951491176 1.29690169536076 0.375 6.1 6 1 abnormal olfaction 0.127847027604246 0.387523951491176 1.29690169536076 0.375 6.1 6 1 impaired muscle relaxation 0.127847027604246 0.387523951491176 1.29690169536076 0.375 6.1 6 1 large intestinal inflammation 0.127847027604246 0.387523951491176 1.29690169536076 0.375 6.1 6 1 blepharitis 0.127847027604246 0.387523951491176 1.29690169536076 0.375 6.1 6 1 kidney degeneration 0.127847027604246 0.387523951491176 1.29690169536076 0.375 6.1 6 1 impaired somite development 0.127847027604246 0.387523951491176 1.29690169536076 0.375 6.1 6 1 decreased skeletal muscle weight 0.127847027604246 0.387523951491176 1.29690169536076 0.375 6.1 6 1 decreased midbrain size 0.127847027604246 0.387523951491176 1.29690169536076 0.375 6.1 6 1 limb grasping 3.54139834795662e-06 0.0001493089557719 1.29215113970009 0.373626373626374 6.1 6 1 abnormal cranium morphology 6.72924656092706e-05 0.00182939899675476 1.29044944812016 0.373134328358209 6.1 6 1 increased sensitivity to xenobiotic induced morbidity/mortality 0.000298170903643138 0.00612975308109343 1.28904168508584 0.372727272727273 6.1 6 1 distended abdomen 0.0117388636225746 0.0915373769942145 1.28842521369173 0.372549019607843 6.1 6 1 abnormal cervical vertebrae morphology 0.0117388636225746 0.0915373769942145 1.28842521369173 0.372549019607843 6.1 6 1 abnormal gluconeogenesis 0.0117388636225746 0.0915373769942145 1.28842521369173 0.372549019607843 6.1 6 1 increased neutrophil cell number 3.75318841163785e-05 0.00109835954987637 1.28795754573758 0.372413793103448 6.1 6 1 abnormal blood vessel morphology 3.75318841163785e-05 0.00109835954987637 1.28795754573758 0.372413793103448 6.1 6 1 decreased leukocyte cell number 6.14412270074697e-05 0.00168878510697327 1.2874352596282 0.372262773722628 6.1 6 1 abnormal organ of Corti morphology 0.0200749871366456 0.133520135033171 1.28684819384633 0.372093023255814 6.1 6 1 abnormal left-right axis patterning 0.0200749871366456 0.133520135033171 1.28684819384633 0.372093023255814 6.1 6 1 impaired macrophage phagocytosis 0.0200749871366456 0.133520135033171 1.28684819384633 0.372093023255814 6.1 6 1 increased rib number 0.00223948888565535 0.0300308819572382 1.28581706548588 0.371794871794872 6.1 6 1 small liver 0.00223948888565535 0.0300308819572382 1.28581706548588 0.371794871794872 6.1 6 1 ovary cysts 0.0347877907974943 0.188118760019059 1.28455025064304 0.371428571428571 6.1 6 1 abnormal artery morphology 0.0347877907974943 0.188118760019059 1.28455025064304 0.371428571428571 6.1 6 1 abnormal midbrain development 0.0347877907974943 0.188118760019059 1.28455025064304 0.371428571428571 6.1 6 1 decreased bone volume 0.0347877907974943 0.188118760019059 1.28455025064304 0.371428571428571 6.1 6 1 embryonic growth arrest 3.22800092536645e-07 2.03282336755672e-05 1.28368726760599 0.37117903930131 6.1 6 1 increased eosinophil cell number 0.00627958076647453 0.0625291928096841 1.28295651584075 0.370967741935484 6.1 6 1 abnormal skeleton development 0.00203474970377797 0.0278101092755368 1.28089056331927 0.37037037037037 6.1 6 1 short snout 0.000407932908247161 0.00795869105305736 1.28089056331927 0.37037037037037 6.1 6 1 diluted coat color 0.010612941276369 0.0884411773030753 1.28089056331927 0.37037037037037 6.1 6 1 abnormal type II pneumocyte morphology 0.0614797664421617 0.253616781135783 1.28089056331927 0.37037037037037 6.1 6 1 cryptorchism 0.0614797664421617 0.253616781135783 1.28089056331927 0.37037037037037 6.1 6 1 decreased susceptibility to pharmacologically induced seizures 0.0614797664421617 0.253616781135783 1.28089056331927 0.37037037037037 6.1 6 1 abnormal fetal cardiomyocyte proliferation 0.0614797664421617 0.253616781135783 1.28089056331927 0.37037037037037 6.1 6 1 abnormal palate morphology 0.0614797664421617 0.253616781135783 1.28089056331927 0.37037037037037 6.1 6 1 abnormal skin appearance 0.0614797664421617 0.253616781135783 1.28089056331927 0.37037037037037 6.1 6 1 thick interventricular septum 0.0614797664421617 0.253616781135783 1.28089056331927 0.37037037037037 6.1 6 1 increased or absent threshold for auditory brainstem response 1.22933909079024e-08 1.54644818451365e-06 1.28044734859147 0.370242214532872 6.1 6 1 abnormal cytokine secretion 2.85436113752628e-05 0.000862225673894551 1.28005881620023 0.37012987012987 6.1 6 1 astrocytosis 0.00339369596404673 0.0401824989081046 1.27913591871198 0.36986301369863 6.1 6 1 cyanosis 3.35917641228263e-06 0.000145320892618314 1.27888917181408 0.369791666666667 6.1 6 1 decreased exploration in new environment 0.00184800416462898 0.0262225760630641 1.27631595416455 0.369047619047619 6.1 6 1 abnormal craniofacial morphology 0.000612384868129475 0.0109197660177209 1.27591623103453 0.368932038834951 6.1 6 1 abnormal craniofacial bone morphology 0.00959146250152628 0.0832766595900406 1.27414903403864 0.368421052631579 6.1 6 1 increased hepatocellular carcinoma incidence 0.00959146250152628 0.0832766595900406 1.27414903403864 0.368421052631579 6.1 6 1 increased bone marrow cell number 0.031214354612751 0.177678837538583 1.27414903403864 0.368421052631579 6.1 6 1 abnormal neurotransmitter level 0.112238276456733 0.380890467511764 1.27414903403864 0.368421052631579 6.1 6 1 increased liver adenoma incidence 0.112238276456733 0.380890467511764 1.27414903403864 0.368421052631579 6.1 6 1 abnormal blastocyst morphology 0.112238276456733 0.380890467511764 1.27414903403864 0.368421052631579 6.1 6 1 abnormal behavioral response to xenobiotic 0.112238276456733 0.380890467511764 1.27414903403864 0.368421052631579 6.1 6 1 abnormal respiratory system physiology 0.0163031133745005 0.114397727839408 1.27043431382278 0.36734693877551 6.1 6 1 abnormal craniofacial development 0.0163031133745005 0.114397727839408 1.27043431382278 0.36734693877551 6.1 6 1 abnormal heart tube morphology 0.0547844537552965 0.230976828332712 1.26808165768607 0.366666666666667 6.1 6 1 abnormal pain threshold 0.0547844537552965 0.230976828332712 1.26808165768607 0.366666666666667 6.1 6 1 liver hemorrhage 0.0547844537552965 0.230976828332712 1.26808165768607 0.366666666666667 6.1 6 1 abnormal optic cup morphology 0.0547844537552965 0.230976828332712 1.26808165768607 0.366666666666667 6.1 6 1 abnormal ovary morphology 0.00466187878740933 0.0504628139946826 1.26645799359173 0.366197183098592 6.1 6 1 thick ventricular wall 0.0280085834777552 0.165490145845406 1.26526994669342 0.365853658536585 6.1 6 1 lethargy 0.00138186182542152 0.0207696754727253 1.2643629431474 0.365591397849462 6.1 6 1 decreased bone mineral content 2.6187082949577e-06 0.000120630312661246 1.26364780573612 0.365384615384615 6.1 6 1 eyelids open at birth 0.0146879361985789 0.105818594025925 1.26364780573612 0.365384615384615 6.1 6 1 postnatal lethality, complete penetrance 1.94070924174416e-10 4.0229285323655e-08 1.26330320584364 0.365284974093264 6.1 6 1 decreased susceptibility to hepatic steatosis 0.00782801733254348 0.0736161158040013 1.26259212670042 0.365079365079365 6.1 6 1 postnatal lethality, incomplete penetrance 1.60871094855594e-14 6.66944747422151e-12 1.26036925323792 0.36443661971831 6.1 6 1 decreased B cell number 3.53360739026041e-06 0.0001493089557719 1.25912785957355 0.364077669902913 6.1 6 1 embryonic lethality, complete penetrance 1.00847920110022e-08 1.32031158565095e-06 1.25760164398619 0.363636363636364 6.1 6 1 increased T cell number 0.00207726155452384 0.0283133595445373 1.25760164398619 0.363636363636364 6.1 6 1 renal interstitial fibrosis 0.0251350175597263 0.153456761391041 1.25760164398619 0.363636363636364 6.1 6 1 abnormal amino acid level 0.0251350175597263 0.153456761391041 1.25760164398619 0.363636363636364 6.1 6 1 increased body size 0.0988029047201087 0.343774786016611 1.25760164398619 0.363636363636364 6.1 6 1 abnormal tail movements 0.0988029047201087 0.343774786016611 1.25760164398619 0.363636363636364 6.1 6 1 intracerebral hemorrhage 0.0988029047201087 0.343774786016611 1.25760164398619 0.363636363636364 6.1 6 1 abnormal tracheal cartilage morphology 0.0988029047201087 0.343774786016611 1.25760164398619 0.363636363636364 6.1 6 1 abnormal blood-brain barrier function 0.0988029047201087 0.343774786016611 1.25760164398619 0.363636363636364 6.1 6 1 decreased circulating estradiol level 0.0988029047201087 0.343774786016611 1.25760164398619 0.363636363636364 6.1 6 1 abnormal occipital bone morphology 0.0988029047201087 0.343774786016611 1.25760164398619 0.363636363636364 6.1 6 1 abnormal sperm midpiece morphology 0.0988029047201087 0.343774786016611 1.25760164398619 0.363636363636364 6.1 6 1 pulmonary vascular congestion 0.0988029047201087 0.343774786016611 1.25760164398619 0.363636363636364 6.1 6 1 decreased circulating calcium level 0.0132318230202181 0.100348048057294 1.25760164398619 0.363636363636364 6.1 6 1 abnormal contextual conditioning behavior 0.0132318230202181 0.100348048057294 1.25760164398619 0.363636363636364 6.1 6 1 abnormal T-helper 2 physiology 0.0132318230202181 0.100348048057294 1.25760164398619 0.363636363636364 6.1 6 1 dextrocardia 0.0488501525594094 0.219141062154564 1.25760164398619 0.363636363636364 6.1 6 1 absent vibrissae 0.0488501525594094 0.219141062154564 1.25760164398619 0.363636363636364 6.1 6 1 abnormal T cell subpopulation ratio 0.0488501525594094 0.219141062154564 1.25760164398619 0.363636363636364 6.1 6 1 decreased sensitivity to xenobiotic induced morbidity/mortality 0.0488501525594094 0.219141062154564 1.25760164398619 0.363636363636364 6.1 6 1 abnormal rib morphology 0.000173710471906491 0.0040009703598833 1.25527275205288 0.362962962962963 6.1 6 1 premature death 9.0275382608221e-21 6.41600040679856e-18 1.25321975672491 0.362369337979094 6.1 6 1 hyperkeratosis 0.00638489044167227 0.0625291928096841 1.25304511629059 0.36231884057971 6.1 6 1 abnormal tibia morphology 0.0225603378285411 0.142073013540496 1.25091227353945 0.361702127659574 6.1 6 1 preweaning lethality, complete penetrance 1.10997204313755e-17 6.90263864326165e-15 1.24782973932008 0.360810810810811 6.1 6 1 increased osteoclast cell number 0.0107382395929245 0.0891865475372281 1.24729343378958 0.360655737704918 6.1 6 1 increased B cell derived lymphoma incidence 0.0202538487755569 0.134350530211194 1.24502562754633 0.36 6.1 6 1 decreased oocyte number 0.0202538487755569 0.134350530211194 1.24502562754633 0.36 6.1 6 1 abnormal feces composition 0.0871825270183565 0.308706812751832 1.24502562754633 0.36 6.1 6 1 decreased neutrophil cell number 0.000631237703718025 0.0111361970780042 1.24147854598637 0.358974358974359 6.1 6 1 abnormal cornea morphology 0.00470115305587297 0.0504628139946826 1.24147854598637 0.358974358974359 6.1 6 1 increased embryonic tissue cell apoptosis 0.00470115305587297 0.0504628139946826 1.24147854598637 0.358974358974359 6.1 6 1 abnormal heart looping 0.0389203735613984 0.197379060619732 1.24147854598637 0.358974358974359 6.1 6 1 abnormal locomotor behavior 0.00231150482901126 0.0302923120345419 1.24051466512768 0.358695652173913 6.1 6 1 azoospermia 8.03896228958443e-05 0.00207221955392137 1.23980539430714 0.358490566037736 6.1 6 1 increased total body fat amount 0.000286917284394033 0.0059475562077513 1.23883147019535 0.358208955223881 6.1 6 1 internal hemorrhage 0.00871640531125476 0.079421458651085 1.23883147019535 0.358208955223881 6.1 6 1 maternal effect 0.00871640531125476 0.079421458651085 1.23883147019535 0.358208955223881 6.1 6 1 increased inflammatory response 0.0020904481551305 0.02833781899666 1.23774477592325 0.357894736842105 6.1 6 1 decreased birth weight 0.0020904481551305 0.02833781899666 1.23774477592325 0.357894736842105 6.1 6 1 male infertility 4.98554386007549e-12 1.7716486217054e-09 1.23760002738203 0.357852882703777 6.1 6 1 neonatal lethality, complete penetrance 5.46408386936469e-11 1.29446748809949e-08 1.23622793183511 0.357456140350877 6.1 6 1 abnormal reproductive system morphology 0.0347753593442119 0.188118760019059 1.23514447177215 0.357142857142857 6.1 6 1 shortened head 0.0770883364156993 0.29188705364132 1.23514447177215 0.357142857142857 6.1 6 1 premature aging 0.0770883364156993 0.29188705364132 1.23514447177215 0.357142857142857 6.1 6 1 abnormal renal tubule epithelium morphology 0.0770883364156993 0.29188705364132 1.23514447177215 0.357142857142857 6.1 6 1 abnormal mitotic spindle morphology 0.0770883364156993 0.29188705364132 1.23514447177215 0.357142857142857 6.1 6 1 abnormal kidney blood vessel morphology 0.187342802430188 0.479325615556261 1.23514447177215 0.357142857142857 6.1 6 1 irregularly shaped pupil 0.187342802430188 0.479325615556261 1.23514447177215 0.357142857142857 6.1 6 1 absent otoliths 0.187342802430188 0.479325615556261 1.23514447177215 0.357142857142857 6.1 6 1 abnormal kidney medulla morphology 0.187342802430188 0.479325615556261 1.23514447177215 0.357142857142857 6.1 6 1 amyloid beta deposits 0.187342802430188 0.479325615556261 1.23514447177215 0.357142857142857 6.1 6 1 absent olfactory bulb 0.187342802430188 0.479325615556261 1.23514447177215 0.357142857142857 6.1 6 1 abnormal voluntary movement 0.187342802430188 0.479325615556261 1.23514447177215 0.357142857142857 6.1 6 1 abnormal decidualization 0.187342802430188 0.479325615556261 1.23514447177215 0.357142857142857 6.1 6 1 split sternum 0.187342802430188 0.479325615556261 1.23514447177215 0.357142857142857 6.1 6 1 premature hair loss 0.187342802430188 0.479325615556261 1.23514447177215 0.357142857142857 6.1 6 1 decreased compact bone area 0.187342802430188 0.479325615556261 1.23514447177215 0.357142857142857 6.1 6 1 abnormal testis morphology 0.000850626175087201 0.0140549141641681 1.23299639442994 0.356521739130435 6.1 6 1 ataxia 1.27574262426246e-05 0.000434713668199023 1.23269864113498 0.356435643564356 6.1 6 1 abnormal spleen morphology 4.95130191057114e-05 0.00140758440029094 1.23230505919336 0.35632183908046 6.1 6 1 short limbs 0.003461369938354 0.0404232756885238 1.23230505919336 0.35632183908046 6.1 6 1 abnormal fertility/fecundity 0.00707786012243801 0.0687741291193927 1.23176051431524 0.356164383561644 6.1 6 1 irregular heartbeat 0.0310917134724679 0.177678837538583 1.2296549407865 0.355555555555556 6.1 6 1 abnormal heart morphology 4.00926677945491e-06 0.000166217518564901 1.2276587477008 0.354978354978355 6.1 6 1 pericardial effusion 0.0131905019474722 0.100348048057294 1.22717579776072 0.354838709677419 6.1 6 1 abnormal postnatal growth/weight/body size 0.0682865820612175 0.276875098414472 1.22717579776072 0.354838709677419 6.1 6 1 abnormal T cell proliferation 0.0682865820612175 0.276875098414472 1.22717579776072 0.354838709677419 6.1 6 1 small cranium 0.0682865820612175 0.276875098414472 1.22717579776072 0.354838709677419 6.1 6 1 decreased susceptibility to bacterial infection induced morbidity/mortality 0.0682865820612175 0.276875098414472 1.22717579776072 0.354838709677419 6.1 6 1 abnormal visceral yolk sac morphology 0.00574993865341886 0.0583794791852221 1.22576362768274 0.354430379746835 6.1 6 1 abnormal response to infection 0.00574993865341886 0.0583794791852221 1.22576362768274 0.354430379746835 6.1 6 1 kyphosis 0.000213182891018669 0.00475598602160484 1.22196959740658 0.353333333333333 6.1 6 1 abnormal embryo development 0.000423752671249089 0.0082029943169814 1.22061336033954 0.352941176470588 6.1 6 1 pericardial edema 0.0106616661618181 0.0886986440719813 1.22061336033954 0.352941176470588 6.1 6 1 overexpanded pulmonary alveoli 0.0605864393119174 0.251600614003998 1.22061336033954 0.352941176470588 6.1 6 1 abnormal direction of heart looping 0.0605864393119174 0.251600614003998 1.22061336033954 0.352941176470588 6.1 6 1 increased susceptibility to viral infection induced morbidity/mortality 0.0605864393119174 0.251600614003998 1.22061336033954 0.352941176470588 6.1 6 1 abnormal urinary bladder morphology 0.161875503745884 0.463633063405742 1.22061336033954 0.352941176470588 6.1 6 1 distended urinary bladder 0.161875503745884 0.463633063405742 1.22061336033954 0.352941176470588 6.1 6 1 increased incidence of corneal inflammation 0.161875503745884 0.463633063405742 1.22061336033954 0.352941176470588 6.1 6 1 absence seizures 0.161875503745884 0.463633063405742 1.22061336033954 0.352941176470588 6.1 6 1 abnormal tarsal bone morphology 0.161875503745884 0.463633063405742 1.22061336033954 0.352941176470588 6.1 6 1 abnormal electroretinogram waveform feature 0.161875503745884 0.463633063405742 1.22061336033954 0.352941176470588 6.1 6 1 delayed heart development 0.161875503745884 0.463633063405742 1.22061336033954 0.352941176470588 6.1 6 1 increased circulating HDL cholesterol level 0.00187854406599193 0.0263260752910136 1.21867587881519 0.352380952380952 6.1 6 1 increased circulating cholesterol level 7.26154221643295e-05 0.00193188088378363 1.21830159261162 0.352272727272727 6.1 6 1 abnormal skeletal muscle fiber morphology 0.00958901366622849 0.0832766595900406 1.21774807076127 0.352112676056338 6.1 6 1 decreased liver weight 0.00958901366622849 0.0832766595900406 1.21774807076127 0.352112676056338 6.1 6 1 polyphagia 0.0222995716669052 0.140608832753933 1.2168460351533 0.351851851851852 6.1 6 1 abnormal lens morphology 0.000691856054448283 0.0121196615171838 1.21584533940071 0.3515625 6.1 6 1 abnormal vocalization 0.0538306691285165 0.22792134375691 1.21511510195963 0.351351351351351 6.1 6 1 decreased circulating chloride level 0.0538306691285165 0.22792134375691 1.21511510195963 0.351351351351351 6.1 6 1 decreased susceptibility to induced arthritis 0.0199822750584268 0.133438682437145 1.21347527051299 0.350877192982456 6.1 6 1 increased macrophage cell number 0.0199822750584268 0.133438682437145 1.21347527051299 0.350877192982456 6.1 6 1 obese 0.00776231184636435 0.0734173031096248 1.21268729955811 0.350649350649351 6.1 6 1 hyperactivity 1.82529616324734e-08 2.0638291845808e-06 1.2118398590972 0.350404312668464 6.1 6 1 abnormal incisor morphology 0.0179144505309927 0.122423614549023 1.21044158233671 0.35 6.1 6 1 abnormal female reproductive system morphology 0.0478885558615285 0.219141062154564 1.21044158233671 0.35 6.1 6 1 perinatal lethality 0.0478885558615285 0.219141062154564 1.21044158233671 0.35 6.1 6 1 small gonad 0.140763173026224 0.411939285767919 1.21044158233671 0.35 6.1 6 1 abnormal circulating enzyme level 0.140763173026224 0.411939285767919 1.21044158233671 0.35 6.1 6 1 increased urine glucose level 0.140763173026224 0.411939285767919 1.21044158233671 0.35 6.1 6 1 increased mammary adenocarcinoma incidence 0.140763173026224 0.411939285767919 1.21044158233671 0.35 6.1 6 1 abnormal dopamine level 0.140763173026224 0.411939285767919 1.21044158233671 0.35 6.1 6 1 abnormal lens epithelium morphology 0.140763173026224 0.411939285767919 1.21044158233671 0.35 6.1 6 1 abnormal physiological neovascularization 0.140763173026224 0.411939285767919 1.21044158233671 0.35 6.1 6 1 dilated vasculature 0.140763173026224 0.411939285767919 1.21044158233671 0.35 6.1 6 1 abnormal incus morphology 0.140763173026224 0.411939285767919 1.21044158233671 0.35 6.1 6 1 abnormal neuron proliferation 0.140763173026224 0.411939285767919 1.21044158233671 0.35 6.1 6 1 abnormal heart electrocardiography waveform feature 0.140763173026224 0.411939285767919 1.21044158233671 0.35 6.1 6 1 abnormal hair follicle morphology 0.0160679327164582 0.113226579694588 1.20769681684388 0.349206349206349 6.1 6 1 skin lesions 0.0160679327164582 0.113226579694588 1.20769681684388 0.349206349206349 6.1 6 1 decreased oxygen consumption 0.0426505587411223 0.214329828017256 1.20642018173094 0.348837209302326 6.1 6 1 insulin resistance 0.000754215503647983 0.0128942341259406 1.20520157548676 0.348484848484849 6.1 6 1 abnormal skin morphology 0.0144179345445459 0.104409351323312 1.20520157548676 0.348484848484849 6.1 6 1 anophthalmia 0.00510045817790475 0.0539625592502657 1.20461281067216 0.348314606741573 6.1 6 1 abnormal coat/hair pigmentation 0.00185007521570563 0.0262225760630641 1.20426585997785 0.348214285714286 6.1 6 1 reduced male fertility 1.36192539815809e-05 0.000454736835962181 1.20358571434361 0.348017621145374 6.1 6 1 decreased T cell number 0.000229707920229415 0.00503434759093101 1.20292331163896 0.347826086956522 6.1 6 1 abnormal inner ear morphology 0.0380242251506017 0.193822254225659 1.20292331163896 0.347826086956522 6.1 6 1 abnormal forelimb morphology 0.0380242251506017 0.193822254225659 1.20292331163896 0.347826086956522 6.1 6 1 abnormal cranial nerve morphology 0.122999442382806 0.387523951491176 1.20292331163896 0.347826086956522 6.1 6 1 abnormal B cell morphology 0.122999442382806 0.387523951491176 1.20292331163896 0.347826086956522 6.1 6 1 abnormal basicranium morphology 0.122999442382806 0.387523951491176 1.20292331163896 0.347826086956522 6.1 6 1 perimembraneous ventricular septal defect 0.0129426132125625 0.0989086032757272 1.20292331163896 0.347826086956522 6.1 6 1 improved glucose tolerance 5.79721766898754e-05 0.00161123787168788 1.19985462972152 0.346938775510204 6.1 6 1 increased T cell derived lymphoma incidence 0.0339310324618007 0.18448840054367 1.19985462972152 0.346938775510204 6.1 6 1 impaired coordination 1.19219154330375e-07 9.29735005347676e-06 1.19944665466891 0.346820809248555 6.1 6 1 impaired glucose tolerance 6.83416627633889e-06 0.000253731173319298 1.1992854387207 0.346774193548387 6.1 6 1 distended pericardium 0.0303039184492791 0.17612382509949 1.19714002648685 0.346153846153846 6.1 6 1 increased susceptibility to injury 0.0303039184492791 0.17612382509949 1.19714002648685 0.346153846153846 6.1 6 1 decreased body temperature 0.0303039184492791 0.17612382509949 1.19714002648685 0.346153846153846 6.1 6 1 abnormal stomach morphology 0.107890617002952 0.370687720711108 1.19714002648685 0.346153846153846 6.1 6 1 abnormal ureter morphology 0.107890617002952 0.370687720711108 1.19714002648685 0.346153846153846 6.1 6 1 abnormal Schwann cell morphology 0.107890617002952 0.370687720711108 1.19714002648685 0.346153846153846 6.1 6 1 increased susceptibility to otitis media 0.107890617002952 0.370687720711108 1.19714002648685 0.346153846153846 6.1 6 1 abnormal ocular fundus morphology 0.107890617002952 0.370687720711108 1.19714002648685 0.346153846153846 6.1 6 1 abnormal nerve conduction 0.107890617002952 0.370687720711108 1.19714002648685 0.346153846153846 6.1 6 1 abnormal neural tube morphology 0.000275228531955373 0.00581954208365824 1.19549785909798 0.345679012345679 6.1 6 1 lung inflammation 0.000817934249973844 0.0137939759105759 1.19518391533246 0.345588235294118 6.1 6 1 abnormal learning/memory/conditioning 0.0270853278971012 0.16176411319097 1.19472156178688 0.345454545454545 6.1 6 1 decreased litter size 2.3123277566994e-06 0.000110613755669034 1.19382647164881 0.345195729537367 6.1 6 1 abnormal microglial cell morphology 0.0949336959188161 0.334723697516733 1.19255328309035 0.344827586206897 6.1 6 1 aphagia 0.0949336959188161 0.334723697516733 1.19255328309035 0.344827586206897 6.1 6 1 decreased trophoblast giant cell number 0.0949336959188161 0.334723697516733 1.19255328309035 0.344827586206897 6.1 6 1 abnormal embryonic erythropoiesis 0.0949336959188161 0.334723697516733 1.19255328309035 0.344827586206897 6.1 6 1 decreased insulin secretion 0.00613801326021324 0.0619403975041802 1.19122822388692 0.344444444444444 6.1 6 1 abnormal long bone morphology 0.0216819612734785 0.137236332487984 1.19059827770824 0.344262295081967 6.1 6 1 increased double-negative T cell number 0.0216819612734785 0.137236332487984 1.19059827770824 0.344262295081967 6.1 6 1 abnormal definitive hematopoiesis 0.00552394630009863 0.0574929557384742 1.18998865237403 0.344086021505376 6.1 6 1 polydipsia 0.0837500818679337 0.300835131619473 1.18882655408069 0.34375 6.1 6 1 abnormal long term potentiation 0.0837500818679337 0.300835131619473 1.18882655408069 0.34375 6.1 6 1 cleft palate 0.00119962549808288 0.0187677259527117 1.18800155300222 0.343511450381679 6.1 6 1 abnormal extraembryonic tissue morphology 0.00403219170496729 0.0453849631950504 1.18670743366344 0.343137254901961 6.1 6 1 abnormal action potential 0.0155974860093306 0.111651068915712 1.18573869290126 0.342857142857143 6.1 6 1 increased carcinoma incidence 0.0740466037542253 0.29188705364132 1.18573869290126 0.342857142857143 6.1 6 1 increased red blood cell distribution width 0.0740466037542253 0.29188705364132 1.18573869290126 0.342857142857143 6.1 6 1 abnormal seminiferous tubule morphology 0.000719968788160327 0.01239392637058 1.1843851099185 0.342465753424658 6.1 6 1 hypoactivity 9.87402950988775e-08 8.56988410379347e-06 1.18337979629735 0.342175066312997 6.1 6 1 abnormal retinal outer nuclear layer morphology 0.0655911526767147 0.267034357255855 1.18313838875016 0.342105263157895 6.1 6 1 abnormal compact bone morphology 0.0655911526767147 0.267034357255855 1.18313838875016 0.342105263157895 6.1 6 1 impaired branching involved in ureteric bud morphogenesis 0.0655911526767147 0.267034357255855 1.18313838875016 0.342105263157895 6.1 6 1 abnormal behavior 4.73858168716401e-06 0.000188595551149128 1.18182888306256 0.341726618705036 6.1 6 1 scaly skin 0.058196689690152 0.244534232439617 1.18091861691386 0.341463414634146 6.1 6 1 increased tumor growth/size 0.058196689690152 0.244534232439617 1.18091861691386 0.341463414634146 6.1 6 1 no abnormal phenotype detected 1.90553208461837e-30 4.74001106048821e-27 1.18004350225332 0.341210374639769 6.1 6 1 abnormal suckling behavior 0.00817108783967648 0.0755836326892748 1.17900154123705 0.340909090909091 6.1 6 1 hypertension 0.0517103214211548 0.220455540956617 1.17900154123705 0.340909090909091 6.1 6 1 abnormal motor capabilities/coordination/movement 0.00143000997796298 0.0214286133745958 1.17900154123705 0.340909090909091 6.1 6 1 hepatic necrosis 0.0460055863490846 0.219141062154564 1.17732919862537 0.340425531914894 6.1 6 1 neuron degeneration 0.0460055863490846 0.219141062154564 1.17732919862537 0.340425531914894 6.1 6 1 increased B cell proliferation 0.029122162024254 0.171458882923863 1.17234051558035 0.338983050847458 6.1 6 1 increased hemoglobin content 0.029122162024254 0.171458882923863 1.17234051558035 0.338983050847458 6.1 6 1 abnormal eye electrophysiology 0.0025699893097036 0.0322057854301648 1.17185607735077 0.338842975206612 6.1 6 1 abnormal immune system physiology 0.00231651940643422 0.0302923120345419 1.17139507968068 0.338709677419355 6.1 6 1 decreased susceptibility to injury 0.0208414372335296 0.137150992376732 1.16975447032539 0.338235294117647 6.1 6 1 polyuria 0.0149959798361856 0.107655122200611 1.16777295513003 0.337662337662338 6.1 6 1 abnormal kidney morphology 0.000405237310183931 0.00795869105305736 1.16597638135291 0.337142857142857 6.1 6 1 abnormal dendritic cell physiology 0.00514299720483152 0.053979770240584 1.16357535284703 0.336448598130841 6.1 6 1 abnormal lung morphology 0.00337988125491365 0.0401310483131155 1.16248891460908 0.336134453781513 6.1 6 1 decreased inflammatory response 0.0143139196488049 0.104073196763111 1.15280150698734 0.333333333333333 6.1 6 1 abnormal limb morphology 0.0198687480683861 0.133428993756322 1.15280150698734 0.333333333333333 6.1 6 1 incomplete embryo turning 0.0389164524643094 0.197379060619732 1.15280150698734 0.333333333333333 6.1 6 1 decreased brain weight 0.0389164524643094 0.197379060619732 1.15280150698734 0.333333333333333 6.1 6 1 oligodactyly 0.0551007676241969 0.232113733217934 1.15280150698734 0.333333333333333 6.1 6 1 altered response to myocardial infarction 0.0620196253954984 0.25563184452577 1.15280150698734 0.333333333333333 6.1 6 1 abnormal spleen white pulp morphology 0.0699073548631221 0.281838809111858 1.15280150698734 0.333333333333333 6.1 6 1 abnormal cytotoxic T cell physiology 0.0699073548631221 0.281838809111858 1.15280150698734 0.333333333333333 6.1 6 1 increased metastatic potential 0.115008317000576 0.387523951491176 1.15280150698734 0.333333333333333 6.1 6 1 abnormal estrous cycle 0.115008317000576 0.387523951491176 1.15280150698734 0.333333333333333 6.1 6 1 abnormal microglial cell physiology 0.115008317000576 0.387523951491176 1.15280150698734 0.333333333333333 6.1 6 1 abnormal malleus morphology 0.149983317549036 0.434323052855912 1.15280150698734 0.333333333333333 6.1 6 1 decreased metastatic potential 0.149983317549036 0.434323052855912 1.15280150698734 0.333333333333333 6.1 6 1 increased stereotypic behavior 0.149983317549036 0.434323052855912 1.15280150698734 0.333333333333333 6.1 6 1 blindness 0.149983317549036 0.434323052855912 1.15280150698734 0.333333333333333 6.1 6 1 abnormal tumor morphology 0.149983317549036 0.434323052855912 1.15280150698734 0.333333333333333 6.1 6 1 abnormal osteoblast morphology 0.149983317549036 0.434323052855912 1.15280150698734 0.333333333333333 6.1 6 1 abnormal mammary gland morphology 0.199273006767149 0.479325615556261 1.15280150698734 0.333333333333333 6.1 6 1 absent spleen 0.199273006767149 0.479325615556261 1.15280150698734 0.333333333333333 6.1 6 1 abnormal eye pigmentation 0.172376039168051 0.479325615556261 1.15280150698734 0.333333333333333 6.1 6 1 abnormal hematopoietic system physiology 0.172376039168051 0.479325615556261 1.15280150698734 0.333333333333333 6.1 6 1 abnormal iron level 0.199273006767149 0.479325615556261 1.15280150698734 0.333333333333333 6.1 6 1 abnormal bile duct morphology 0.199273006767149 0.479325615556261 1.15280150698734 0.333333333333333 6.1 6 1 abnormal metacarpal bone morphology 0.199273006767149 0.479325615556261 1.15280150698734 0.333333333333333 6.1 6 1 abnormal redox activity 0.199273006767149 0.479325615556261 1.15280150698734 0.333333333333333 6.1 6 1 abnormal embryonic/fetal subventricular zone morphology 0.172376039168051 0.479325615556261 1.15280150698734 0.333333333333333 6.1 6 1 long tibia 0.199273006767149 0.479325615556261 1.15280150698734 0.333333333333333 6.1 6 1 abnormal anterior eye segment morphology 0.199273006767149 0.479325615556261 1.15280150698734 0.333333333333333 6.1 6 1 abnormal eye anterior chamber morphology 0.199273006767149 0.479325615556261 1.15280150698734 0.333333333333333 6.1 6 1 complete atrioventricular septal defect 0.172376039168051 0.479325615556261 1.15280150698734 0.333333333333333 6.1 6 1 abnormal hypoglossal nerve topology 0.199273006767149 0.479325615556261 1.15280150698734 0.333333333333333 6.1 6 1 increased bone ossification 0.172376039168051 0.479325615556261 1.15280150698734 0.333333333333333 6.1 6 1 decreased vocalization 0.172376039168051 0.479325615556261 1.15280150698734 0.333333333333333 6.1 6 1 increased muscle cell glucose uptake 0.172376039168051 0.479325615556261 1.15280150698734 0.333333333333333 6.1 6 1 abnormal fontanelle morphology 0.232168875144335 0.492764570752162 1.15280150698734 0.333333333333333 6.1 6 1 macrocytosis 0.232168875144335 0.492764570752162 1.15280150698734 0.333333333333333 6.1 6 1 decreased salivation 0.232168875144335 0.492764570752162 1.15280150698734 0.333333333333333 6.1 6 1 abnormal apical ectodermal ridge morphology 0.232168875144335 0.492764570752162 1.15280150698734 0.333333333333333 6.1 6 1 absent egg cylinders 0.232168875144335 0.492764570752162 1.15280150698734 0.333333333333333 6.1 6 1 increased airway responsiveness 0.232168875144335 0.492764570752162 1.15280150698734 0.333333333333333 6.1 6 1 abnormal bronchus morphology 0.232168875144335 0.492764570752162 1.15280150698734 0.333333333333333 6.1 6 1 altered righting response 0.232168875144335 0.492764570752162 1.15280150698734 0.333333333333333 6.1 6 1 increased alcohol consumption 0.232168875144335 0.492764570752162 1.15280150698734 0.333333333333333 6.1 6 1 immune system phenotype 0.232168875144335 0.492764570752162 1.15280150698734 0.333333333333333 6.1 6 1 abnormal neurotransmitter secretion 0.232168875144335 0.492764570752162 1.15280150698734 0.333333333333333 6.1 6 1 abnormal Muller cell morphology 0.232168875144335 0.492764570752162 1.15280150698734 0.333333333333333 6.1 6 1 abnormal secondary palate development 0.232168875144335 0.492764570752162 1.15280150698734 0.333333333333333 6.1 6 1 lactation failure 0.232168875144335 0.492764570752162 1.15280150698734 0.333333333333333 6.1 6 1 abnormal neuronal precursor proliferation 0.0436529590357284 0.217390862064814 1.15280150698734 0.333333333333333 6.1 6 1 abnormal osteoblast physiology 0.0436529590357284 0.217390862064814 1.15280150698734 0.333333333333333 6.1 6 1 increased autoantibody level 0.0789265422343727 0.293262665644997 1.15280150698734 0.333333333333333 6.1 6 1 abnormal ovarian folliculogenesis 0.101200046522196 0.35109500100971 1.15280150698734 0.333333333333333 6.1 6 1 abnormal locomotor coordination 0.101200046522196 0.35109500100971 1.15280150698734 0.333333333333333 6.1 6 1 single kidney 0.101200046522196 0.35109500100971 1.15280150698734 0.333333333333333 6.1 6 1 rectal prolapse 0.131096042283346 0.387523951491176 1.15280150698734 0.333333333333333 6.1 6 1 abnormal trigeminal ganglion morphology 0.131096042283346 0.387523951491176 1.15280150698734 0.333333333333333 6.1 6 1 abnormal bone trabecula morphology 0.131096042283346 0.387523951491176 1.15280150698734 0.333333333333333 6.1 6 1 decreased T cell proliferation 0.00183880328405965 0.0262121671581569 1.1450123076158 0.331081081081081 6.1 6 1 abnormal cardiovascular system physiology 0.00308785607743895 0.037017069843997 1.14413382648368 0.330827067669173 6.1 6 1 decreased double-positive T cell number 0.00984273561144075 0.0851610602902917 1.14127349191747 0.33 6.1 6 1 abnormal B cell differentiation 0.0135872697671049 0.101192615406208 1.14013335855891 0.32967032967033 6.1 6 1 small kidney 0.015140666027305 0.108537195224557 1.13970148986248 0.329545454545455 6.1 6 1 decreased B cell proliferation 0.0210074845629845 0.137236332487984 1.13820908284826 0.329113924050633 6.1 6 1 abnormal axial skeleton morphology 0.023454682125012 0.146776155436396 1.13763306610593 0.328947368421053 6.1 6 1 impaired fertilization 0.0292897291248152 0.172241610397111 1.13633291403038 0.328571428571429 6.1 6 1 decreased eosinophil cell number 0.0366760213146166 0.191715560094796 1.13478898344066 0.328125 6.1 6 1 abnormal embryo turning 0.0517128876977633 0.220455540956617 1.13184147958757 0.327272727272727 6.1 6 1 infertility 0.00931882218125363 0.0827183992685586 1.13125381526795 0.327102803738318 6.1 6 1 cachexia 0.0103665996305647 0.0866331759209257 1.13063224723758 0.326923076923077 6.1 6 1 abnormal snout morphology 0.0581048567736495 0.244534232439617 1.13063224723758 0.326923076923077 6.1 6 1 decreased urine osmolality 0.0653648816423284 0.267034357255855 1.12927494562025 0.326530612244898 6.1 6 1 increased circulating glucose level 0.00342558469071164 0.0401824989081046 1.12827381534931 0.326241134751773 6.1 6 1 embryonic lethality between implantation and placentation, complete penetrance 0.0736303029333517 0.29188705364132 1.12774060466153 0.326086956521739 6.1 6 1 small testis 6.19032733007185e-05 0.0016921361795114 1.12774060466153 0.326086956521739 6.1 6 1 increased body weight 0.000293941522873968 0.00606787998463897 1.12706933049209 0.325892857142857 6.1 6 1 abnormal muscle physiology 0.0177546492118505 0.12149845918701 1.12689585514493 0.325842696629214 6.1 6 1 abnormal axon guidance 0.0830658081633976 0.298808673617428 1.12599216961554 0.325581395348837 6.1 6 1 kidney failure 0.0830658081633976 0.298808673617428 1.12599216961554 0.325581395348837 6.1 6 1 abnormal double-strand DNA break repair 0.0830658081633976 0.298808673617428 1.12599216961554 0.325581395348837 6.1 6 1 increased circulating insulin level 0.00214343544243334 0.0289771503426789 1.12398146931266 0.325 6.1 6 1 decreased IgG level 0.00977660260519247 0.0847362333812413 1.1216447095012 0.324324324324324 6.1 6 1 kidney cysts 0.0307505663518741 0.177678837538583 1.1216447095012 0.324324324324324 6.1 6 1 abnormal humerus morphology 0.106289206182326 0.366959611906365 1.1216447095012 0.324324324324324 6.1 6 1 abnormal humoral immune response 0.0120949779845797 0.0938728790534854 1.11986432107342 0.323809523809524 6.1 6 1 impaired balance 0.013459240194307 0.100532087274243 1.11889558031124 0.323529411764706 6.1 6 1 short maxilla 0.120623945622764 0.387523951491176 1.11889558031124 0.323529411764706 6.1 6 1 decreased pancreatic beta cell number 0.120623945622764 0.387523951491176 1.11889558031124 0.323529411764706 6.1 6 1 retinal degeneration 0.016684264277017 0.116907344757971 1.11677645989399 0.322916666666667 6.1 6 1 osteopetrosis 0.137256762209794 0.404533407579222 1.11561436160065 0.32258064516129 6.1 6 1 abnormal object recognition memory 0.137256762209794 0.404533407579222 1.11561436160065 0.32258064516129 6.1 6 1 increased lung adenoma incidence 0.137256762209794 0.404533407579222 1.11561436160065 0.32258064516129 6.1 6 1 decreased double-negative T cell number 0.137256762209794 0.404533407579222 1.11561436160065 0.32258064516129 6.1 6 1 abnormal thoracic vertebrae morphology 0.0541253998186737 0.22897437423291 1.11372348980133 0.322033898305085 6.1 6 1 abnormal nervous system physiology 0.0102189673668975 0.0866331759209257 1.11270406326604 0.321739130434783 6.1 6 1 abnormal skeleton morphology 0.0102189673668975 0.0866331759209257 1.11270406326604 0.321739130434783 6.1 6 1 arrest of spermatogenesis 0.0257624730606659 0.154145317600598 1.11163002459493 0.321428571428571 6.1 6 1 abnormal seminal vesicle morphology 0.0607639639776967 0.252127373468758 1.11163002459493 0.321428571428571 6.1 6 1 absent corpus callosum 0.156678639799601 0.451608477985523 1.11163002459493 0.321428571428571 6.1 6 1 microphthalmia 0.00391418056768283 0.0448666821749434 1.10759360475254 0.320261437908497 6.1 6 1 abnormal neurocranium morphology 0.0358714220146918 0.191715560094796 1.10668944670785 0.32 6.1 6 1 abnormal hindlimb morphology 0.0768416003630597 0.29188705364132 1.10668944670785 0.32 6.1 6 1 short stride length 0.0768416003630597 0.29188705364132 1.10668944670785 0.32 6.1 6 1 mandible hypoplasia 0.179536630739945 0.479325615556261 1.10668944670785 0.32 6.1 6 1 decreased acute inflammation 0.179536630739945 0.479325615556261 1.10668944670785 0.32 6.1 6 1 abnormal vertebrae development 0.179536630739945 0.479325615556261 1.10668944670785 0.32 6.1 6 1 abnormal inflammatory response 0.0401038335442819 0.203042835971491 1.10476811086287 0.319444444444444 6.1 6 1 pulmonary hypoplasia 0.0865793888322267 0.308565153898997 1.10374612371128 0.319148936170213 6.1 6 1 abnormal T-helper 1 physiology 0.0865793888322267 0.308565153898997 1.10374612371128 0.319148936170213 6.1 6 1 abnormal abdominal fat pad morphology 0.20671016857709 0.479325615556261 1.10040143848792 0.318181818181818 6.1 6 1 testis hypoplasia 0.20671016857709 0.479325615556261 1.10040143848792 0.318181818181818 6.1 6 1 cleft upper lip 0.20671016857709 0.479325615556261 1.10040143848792 0.318181818181818 6.1 6 1 abnormal mesenteric lymph node morphology 0.20671016857709 0.479325615556261 1.10040143848792 0.318181818181818 6.1 6 1 failure of palatal shelf elevation 0.20671016857709 0.479325615556261 1.10040143848792 0.318181818181818 6.1 6 1 embryonic lethality before implantation, incomplete penetrance 0.20671016857709 0.479325615556261 1.10040143848792 0.318181818181818 6.1 6 1 increased T cell proliferation 0.0162549696019663 0.114382565445237 1.09893227768887 0.317757009345794 6.1 6 1 decreased anxiety-related response 0.0110563909335316 0.0897404924855472 1.0965672871343 0.317073170731707 6.1 6 1 abnormal developmental patterning 0.0333606301737831 0.181913574958076 1.0965672871343 0.317073170731707 6.1 6 1 abnormal nervous system morphology 0.0372438114016265 0.191715560094796 1.09443181043102 0.316455696202532 6.1 6 1 decreased startle reflex 0.0136407959014746 0.101439401509471 1.09368348098799 0.316239316239316 6.1 6 1 hyporesponsive to tactile stimuli 0.125072923184916 0.387523951491176 1.09212774346169 0.315789473684211 6.1 6 1 decreased total retina thickness 0.125072923184916 0.387523951491176 1.09212774346169 0.315789473684211 6.1 6 1 abnormal triglyceride level 0.239442882295033 0.503265035664465 1.09212774346169 0.315789473684211 6.1 6 1 irregular coat pigmentation 0.239442882295033 0.503265035664465 1.09212774346169 0.315789473684211 6.1 6 1 enlarged adrenal glands 0.239442882295033 0.503265035664465 1.09212774346169 0.315789473684211 6.1 6 1 unresponsive to tactile stimuli 0.239442882295033 0.503265035664465 1.09212774346169 0.315789473684211 6.1 6 1 altered susceptibility to infection 0.239442882295033 0.503265035664465 1.09212774346169 0.315789473684211 6.1 6 1 delayed sexual maturation 0.239442882295033 0.503265035664465 1.09212774346169 0.315789473684211 6.1 6 1 increased malignant tumor incidence 0.239442882295033 0.503265035664465 1.09212774346169 0.315789473684211 6.1 6 1 abnormal nasal septum morphology 0.239442882295033 0.503265035664465 1.09212774346169 0.315789473684211 6.1 6 1 abnormal metatarsal bone morphology 0.239442882295033 0.503265035664465 1.09212774346169 0.315789473684211 6.1 6 1 maternal imprinting 0.239442882295033 0.503265035664465 1.09212774346169 0.315789473684211 6.1 6 1 abnormal sternebra morphology 0.239442882295033 0.503265035664465 1.09212774346169 0.315789473684211 6.1 6 1 absent amnion 0.239442882295033 0.503265035664465 1.09212774346169 0.315789473684211 6.1 6 1 increased circulating VLDL cholesterol level 0.239442882295033 0.503265035664465 1.09212774346169 0.315789473684211 6.1 6 1 decreased eye pigmentation 0.239442882295033 0.503265035664465 1.09212774346169 0.315789473684211 6.1 6 1 Leydig cell hypoplasia 0.239442882295033 0.503265035664465 1.09212774346169 0.315789473684211 6.1 6 1 decreased susceptibility to weight gain 0.239442882295033 0.503265035664465 1.09212774346169 0.315789473684211 6.1 6 1 decreased liver glycogen level 0.239442882295033 0.503265035664465 1.09212774346169 0.315789473684211 6.1 6 1 thin interventricular septum 0.239442882295033 0.503265035664465 1.09212774346169 0.315789473684211 6.1 6 1 abnormal mandible morphology 0.0796105174897752 0.293262665644997 1.08875697882138 0.314814814814815 6.1 6 1 abnormal retina morphology 0.00159396635610515 0.0234614870462222 1.08692713515949 0.314285714285714 6.1 6 1 abnormal embryonic epiblast morphology 0.141971893979177 0.414988350497301 1.08692713515949 0.314285714285714 6.1 6 1 abnormal hippocampus pyramidal cell morphology 0.141971893979177 0.414988350497301 1.08692713515949 0.314285714285714 6.1 6 1 abnormal motor coordination/ balance 0.0257786742198387 0.154145317600598 1.08293474898811 0.313131313131313 6.1 6 1 abnormal neuron differentiation 0.0193393100612755 0.130546903059492 1.08075141280063 0.3125 6.1 6 1 abnormal posture 0.042970213570734 0.215477645902598 1.08075141280063 0.3125 6.1 6 1 decreased caudal vertebrae number 0.0651922192813979 0.267034357255855 1.08075141280063 0.3125 6.1 6 1 abnormal kidney physiology 0.100887853017695 0.35074568047731 1.08075141280063 0.3125 6.1 6 1 abnormal crypts of Lieberkuhn morphology 0.161577980547004 0.463633063405742 1.08075141280063 0.3125 6.1 6 1 kidney cortex cysts 0.161577980547004 0.463633063405742 1.08075141280063 0.3125 6.1 6 1 abnormal lymphatic vessel morphology 0.161577980547004 0.463633063405742 1.08075141280063 0.3125 6.1 6 1 abnormal serotonin level 0.161577980547004 0.463633063405742 1.08075141280063 0.3125 6.1 6 1 abnormal bone marrow cell number 0.279587896753467 0.561093096550423 1.08075141280063 0.3125 6.1 6 1 mixed cellular infiltration to dermis 0.279587896753467 0.561093096550423 1.08075141280063 0.3125 6.1 6 1 disorganized retinal layers 0.279587896753467 0.561093096550423 1.08075141280063 0.3125 6.1 6 1 reduced male mating frequency 0.279587896753467 0.561093096550423 1.08075141280063 0.3125 6.1 6 1 abnormal extraembryonic endoderm formation 0.279587896753467 0.561093096550423 1.08075141280063 0.3125 6.1 6 1 white spotting 0.279587896753467 0.561093096550423 1.08075141280063 0.3125 6.1 6 1 abnormal molar crown morphology 0.279587896753467 0.561093096550423 1.08075141280063 0.3125 6.1 6 1 bowed tibia 0.279587896753467 0.561093096550423 1.08075141280063 0.3125 6.1 6 1 decreased circulating growth hormone level 0.279587896753467 0.561093096550423 1.08075141280063 0.3125 6.1 6 1 decreased circulating prolactin level 0.279587896753467 0.561093096550423 1.08075141280063 0.3125 6.1 6 1 loose skin 0.279587896753467 0.561093096550423 1.08075141280063 0.3125 6.1 6 1 abnormal thoracic cage shape 0.279587896753467 0.561093096550423 1.08075141280063 0.3125 6.1 6 1 decreased fibroblast apoptosis 0.279587896753467 0.561093096550423 1.08075141280063 0.3125 6.1 6 1 decreased adipocyte glucose uptake 0.279587896753467 0.561093096550423 1.08075141280063 0.3125 6.1 6 1 abnormal cartilage development 0.113811349464613 0.38570263187088 1.07594807318818 0.311111111111111 6.1 6 1 abnormal trabecular bone morphology 0.0179394423035903 0.122426235199399 1.0753022460134 0.310924369747899 6.1 6 1 abnormal gait 0.000264446308486766 0.00567077752035199 1.07445577350276 0.310679611650485 6.1 6 1 dermatitis 0.0819956953468731 0.295600423442532 1.07329795478132 0.310344827586207 6.1 6 1 abnormal circulating glucose level 0.184463864545954 0.479325615556261 1.07329795478132 0.310344827586207 6.1 6 1 stomach inflammation 0.184463864545954 0.479325615556261 1.07329795478132 0.310344827586207 6.1 6 1 short sternum 0.184463864545954 0.479325615556261 1.07329795478132 0.310344827586207 6.1 6 1 abnormal CD8-positive, alpha-beta T cell physiology 0.184463864545954 0.479325615556261 1.07329795478132 0.310344827586207 6.1 6 1 decreased bone strength 0.184463864545954 0.479325615556261 1.07329795478132 0.310344827586207 6.1 6 1 abnormal muscle morphology 0.128600708565063 0.387523951491176 1.07045854220253 0.30952380952381 6.1 6 1 cleft secondary palate 0.0365783020207839 0.191715560094796 1.06695458625424 0.308510638297872 6.1 6 1 absent corpus luteum 0.103542713300113 0.358223225777513 1.06412446798831 0.307692307692308 6.1 6 1 decreased IgA level 0.103542713300113 0.358223225777513 1.06412446798831 0.307692307692308 6.1 6 1 abnormal female meiosis 0.103542713300113 0.358223225777513 1.06412446798831 0.307692307692308 6.1 6 1 abnormal response to injury 0.145582425829601 0.424470053686696 1.06412446798831 0.307692307692308 6.1 6 1 abnormal xiphoid process morphology 0.211379303511942 0.479325615556261 1.06412446798831 0.307692307692308 6.1 6 1 abnormal tectorial membrane morphology 0.211379303511942 0.479325615556261 1.06412446798831 0.307692307692308 6.1 6 1 decreased bone resorption 0.211379303511942 0.479325615556261 1.06412446798831 0.307692307692308 6.1 6 1 abnormal T cell differentiation 0.0337146349113472 0.183512372739554 1.0614904965329 0.306930693069307 6.1 6 1 increased circulating LDL cholesterol level 0.116559752153886 0.387523951491176 1.05869526151899 0.306122448979592 6.1 6 1 absent kidney 0.116559752153886 0.387523951491176 1.05869526151899 0.306122448979592 6.1 6 1 heart right ventricle hypertrophy 0.1651582516272 0.471865922644787 1.05673471473839 0.305555555555556 6.1 6 1 abnormal limb bone morphology 0.1651582516272 0.471865922644787 1.05673471473839 0.305555555555556 6.1 6 1 short radius 0.1651582516272 0.471865922644787 1.05673471473839 0.305555555555556 6.1 6 1 abnormal trophoblast giant cell morphology 0.1651582516272 0.471865922644787 1.05673471473839 0.305555555555556 6.1 6 1 bidirectional circling 0.24333361128709 0.510795238883237 1.05255789768409 0.304347826086957 6.1 6 1 hypotension 0.24333361128709 0.510795238883237 1.05255789768409 0.304347826086957 6.1 6 1 dilated heart 0.24333361128709 0.510795238883237 1.05255789768409 0.304347826086957 6.1 6 1 hydroencephaly 0.0286117341581015 0.168853354017266 1.05255789768409 0.304347826086957 6.1 6 1 short mandible 0.105746426484915 0.365339216501704 1.04987280100633 0.303571428571429 6.1 6 1 abnormal eye development 0.105746426484915 0.365339216501704 1.04987280100633 0.303571428571429 6.1 6 1 abnormal neuron morphology 0.0425763609035118 0.214173301814936 1.04800136998849 0.303030303030303 6.1 6 1 impaired swimming 0.0858060399234703 0.307775810107617 1.04800136998849 0.303030303030303 6.1 6 1 abnormal aorta morphology 0.187829256209963 0.479325615556261 1.04800136998849 0.303030303030303 6.1 6 1 dilated heart atrium 0.187829256209963 0.479325615556261 1.04800136998849 0.303030303030303 6.1 6 1 abnormal middle ear ossicle morphology 0.187829256209963 0.479325615556261 1.04800136998849 0.303030303030303 6.1 6 1 abnormal embryo size 0.03588273878599 0.191715560094796 1.04058189126291 0.300884955752212 6.1 6 1 intracranial hemorrhage 0.10756689663022 0.370687720711108 1.03752135628861 0.3 6.1 6 1 increased circulating chloride level 0.133581817207097 0.394637494421205 1.03752135628861 0.3 6.1 6 1 emphysema 0.214230527779687 0.479325615556261 1.03752135628861 0.3 6.1 6 1 abnormal basioccipital bone morphology 0.281734186267379 0.562075195859082 1.03752135628861 0.3 6.1 6 1 brain inflammation 0.281734186267379 0.562075195859082 1.03752135628861 0.3 6.1 6 1 absent placental labyrinth 0.281734186267379 0.562075195859082 1.03752135628861 0.3 6.1 6 1 spleen atrophy 0.281734186267379 0.562075195859082 1.03752135628861 0.3 6.1 6 1 abnormal myocardial fiber morphology 0.0534795230337286 0.226820653958056 1.03395599080308 0.298969072164948 6.1 6 1 abnormal retinal pigmentation 0.065051057140263 0.267034357255855 1.0335461786783 0.298850574712644 6.1 6 1 decreased compact bone thickness 0.0975514596592108 0.342261280693257 1.03235955849612 0.298507462686567 6.1 6 1 abnormal innervation 0.150401356075295 0.435027178182902 1.0301630487972 0.297872340425532 6.1 6 1 decreased bone trabecula number 0.150401356075295 0.435027178182902 1.0301630487972 0.297872340425532 6.1 6 1 abnormal T cell activation 0.0885874339661204 0.313458381210135 1.02817431704276 0.297297297297297 6.1 6 1 increased circulating phosphate level 0.190064386238493 0.479325615556261 1.02817431704276 0.297297297297297 6.1 6 1 impaired skeletal muscle contractility 0.190064386238493 0.479325615556261 1.02817431704276 0.297297297297297 6.1 6 1 abnormal pancreatic beta cell physiology 0.190064386238493 0.479325615556261 1.02817431704276 0.297297297297297 6.1 6 1 increased trabecular bone volume 0.190064386238493 0.479325615556261 1.02817431704276 0.297297297297297 6.1 6 1 abnormal locomotor activation 0.0659809215093034 0.268401540890257 1.02612002270302 0.296703296703297 6.1 6 1 increased exploration in new environment 0.0805445802644893 0.293262665644997 1.02471245065541 0.296296296296296 6.1 6 1 abnormal trigeminal nerve morphology 0.245182781923981 0.513348238961496 1.02471245065541 0.296296296296296 6.1 6 1 decreased bone ossification 0.245182781923981 0.513348238961496 1.02471245065541 0.296296296296296 6.1 6 1 polydactyly 0.0602013742840064 0.250629152353918 1.02340541946835 0.295918367346939 6.1 6 1 atelectasis 0.0988136570861817 0.343774786016611 1.02290837943947 0.295774647887324 6.1 6 1 abnormal gastrulation 0.151923476723015 0.439174489655433 1.01717780028295 0.294117647058824 6.1 6 1 lung hemorrhage 0.21583146895463 0.479325615556261 1.01717780028295 0.294117647058824 6.1 6 1 impaired synaptic plasticity 0.21583146895463 0.479325615556261 1.01717780028295 0.294117647058824 6.1 6 1 abnormal vision 0.21583146895463 0.479325615556261 1.01717780028295 0.294117647058824 6.1 6 1 decreased regulatory T cell number 0.21583146895463 0.479325615556261 1.01717780028295 0.294117647058824 6.1 6 1 decreased osteoblast cell number 0.21583146895463 0.479325615556261 1.01717780028295 0.294117647058824 6.1 6 1 decreased cytotoxic T cell cytolysis 0.21583146895463 0.479325615556261 1.01717780028295 0.294117647058824 6.1 6 1 increased susceptibility to weight gain 0.21583146895463 0.479325615556261 1.01717780028295 0.294117647058824 6.1 6 1 abnormal vagus nerve morphology 0.328634727173292 0.620241945253084 1.01717780028295 0.294117647058824 6.1 6 1 abnormal heart rate 0.328634727173292 0.620241945253084 1.01717780028295 0.294117647058824 6.1 6 1 abnormal cranial suture morphology 0.328634727173292 0.620241945253084 1.01717780028295 0.294117647058824 6.1 6 1 decreased vasoconstriction 0.328634727173292 0.620241945253084 1.01717780028295 0.294117647058824 6.1 6 1 abnormal melanosome morphology 0.328634727173292 0.620241945253084 1.01717780028295 0.294117647058824 6.1 6 1 coloboma 0.328634727173292 0.620241945253084 1.01717780028295 0.294117647058824 6.1 6 1 abnormal survival 0.328634727173292 0.620241945253084 1.01717780028295 0.294117647058824 6.1 6 1 arrested B cell differentiation 0.191459404166458 0.479325615556261 1.01221595735474 0.292682926829268 6.1 6 1 thymus atrophy 0.170789269099012 0.479325615556261 1.00870131861392 0.291666666666667 6.1 6 1 abnormal foregut morphology 0.281771967532171 0.562075195859082 1.00870131861392 0.291666666666667 6.1 6 1 abnormal startle reflex 0.281771967532171 0.562075195859082 1.00870131861392 0.291666666666667 6.1 6 1 abnormal vasodilation 0.281771967532171 0.562075195859082 1.00870131861392 0.291666666666667 6.1 6 1 apnea 0.281771967532171 0.562075195859082 1.00870131861392 0.291666666666667 6.1 6 1 decreased ovulation rate 0.281771967532171 0.562075195859082 1.00870131861392 0.291666666666667 6.1 6 1 increased hemangiosarcoma incidence 0.281771967532171 0.562075195859082 1.00870131861392 0.291666666666667 6.1 6 1 abnormal retinal ganglion layer morphology 0.281771967532171 0.562075195859082 1.00870131861392 0.291666666666667 6.1 6 1 increased circulating total protein level 0.281771967532171 0.562075195859082 1.00870131861392 0.291666666666667 6.1 6 1 abnormal rostral-caudal axis patterning 0.153001666608042 0.442034431692804 1.00608131518895 0.290909090909091 6.1 6 1 abnormal cranial ganglia morphology 0.245719795512825 0.513636967511053 1.00405292544059 0.290322580645161 6.1 6 1 abnormal podocyte morphology 0.245719795512825 0.513636967511053 1.00405292544059 0.290322580645161 6.1 6 1 abnormal sternum morphology 0.123966467706818 0.387523951491176 1.00243609303247 0.289855072463768 6.1 6 1 abnormal food intake 0.123966467706818 0.387523951491176 1.00243609303247 0.289855072463768 6.1 6 1 abnormal frontal bone morphology 0.216542389704766 0.479325615556261 1.00111709817322 0.289473684210526 6.1 6 1 increased susceptibility to parasitic infection 0.0919250379160011 0.325037003292186 0.999094639389028 0.288888888888889 6.1 6 1 abnormal autopod morphology 0.192216560496969 0.479325615556261 0.999094639389028 0.288888888888889 6.1 6 1 cardiomyopathy 0.192216560496969 0.479325615556261 0.999094639389028 0.288888888888889 6.1 6 1 abnormal brain wave pattern 0.1715372997323 0.479325615556261 0.997616688739044 0.288461538461538 6.1 6 1 abnormal spatial learning 0.0333294780911617 0.181913574958076 0.997208665553466 0.288343558282209 6.1 6 1 syndactyly 0.153715814890099 0.443582470463017 0.996489438243293 0.288135593220339 6.1 6 1 abnormal optic nerve morphology 0.216602882407016 0.479325615556261 0.98811557741772 0.285714285714286 6.1 6 1 holoprosencephaly 0.245375298944811 0.513348238961496 0.98811557741772 0.285714285714286 6.1 6 1 decreased bone mineralization 0.245375298944811 0.513348238961496 0.98811557741772 0.285714285714286 6.1 6 1 increased circulating luteinizing hormone level 0.280584438773733 0.562075195859082 0.98811557741772 0.285714285714286 6.1 6 1 abnormal respiration 0.280584438773733 0.562075195859082 0.98811557741772 0.285714285714286 6.1 6 1 abnormal hormone level 0.280584438773733 0.562075195859082 0.98811557741772 0.285714285714286 6.1 6 1 increased vasoconstriction 0.325477445107111 0.619953723832607 0.98811557741772 0.285714285714286 6.1 6 1 increased acute inflammation 0.325477445107111 0.619953723832607 0.98811557741772 0.285714285714286 6.1 6 1 abnormal stapes morphology 0.325477445107111 0.619953723832607 0.98811557741772 0.285714285714286 6.1 6 1 increased thermal nociceptive threshold 0.10230268447868 0.354673069882533 0.98811557741772 0.285714285714286 6.1 6 1 short femur 0.113255996651155 0.384082197232104 0.98250128436421 0.284090909090909 6.1 6 1 increased bone mineral density 0.0847203163277982 0.304100702547472 0.979371191776855 0.283185840707965 6.1 6 1 abnormal lymphocyte physiology 0.216178319323456 0.479325615556261 0.977375190706658 0.282608695652174 6.1 6 1 small lens 0.244419518370009 0.512210237527714 0.975447428989287 0.282051282051282 6.1 6 1 abnormal iris morphology 0.244419518370009 0.512210237527714 0.975447428989287 0.282051282051282 6.1 6 1 abnormal lens fiber morphology 0.244419518370009 0.512210237527714 0.975447428989287 0.282051282051282 6.1 6 1 abnormal leukocyte adhesion 0.244419518370009 0.512210237527714 0.975447428989287 0.282051282051282 6.1 6 1 abnormal CD4-positive, alpha-beta T cell physiology 0.154243307808155 0.444846641359751 0.974198456609019 0.28169014084507 6.1 6 1 increased sacral vertebrae number 0.171764624300598 0.479325615556261 0.972676271520568 0.28125 6.1 6 1 abnormal lumbar vertebrae morphology 0.27864485354293 0.561093096550423 0.972676271520568 0.28125 6.1 6 1 abnormal depression-related behavior 0.27864485354293 0.561093096550423 0.972676271520568 0.28125 6.1 6 1 abnormal egg cylinder morphology 0.321530154062481 0.618566325004193 0.968353265869365 0.28 6.1 6 1 increased pre-B cell number 0.321530154062481 0.618566325004193 0.968353265869365 0.28 6.1 6 1 increased cellular sensitivity to ionizing radiation 0.321530154062481 0.618566325004193 0.968353265869365 0.28 6.1 6 1 abnormal stomach mucosa morphology 0.321530154062481 0.618566325004193 0.968353265869365 0.28 6.1 6 1 decreased IgM level 0.125003250325639 0.387523951491176 0.962648681092521 0.278350515463918 6.1 6 1 increased susceptibility to bacterial infection induced morbidity/mortality 0.170783193451308 0.479325615556261 0.96066792248945 0.277777777777778 6.1 6 1 reduced long term depression 0.276228009451584 0.557951419822019 0.96066792248945 0.277777777777778 6.1 6 1 abnormal pharyngeal arch morphology 0.276228009451584 0.557951419822019 0.96066792248945 0.277777777777778 6.1 6 1 abnormal mitral valve morphology 0.37838923502181 0.661659596517487 0.96066792248945 0.277777777777778 6.1 6 1 blepharoptosis 0.37838923502181 0.661659596517487 0.96066792248945 0.277777777777778 6.1 6 1 absent ureter 0.37838923502181 0.661659596517487 0.96066792248945 0.277777777777778 6.1 6 1 increased susceptibility to autoimmune disorder 0.37838923502181 0.661659596517487 0.96066792248945 0.277777777777778 6.1 6 1 abnormal glycogen homeostasis 0.37838923502181 0.661659596517487 0.96066792248945 0.277777777777778 6.1 6 1 abnormal macrophage chemotaxis 0.37838923502181 0.661659596517487 0.96066792248945 0.277777777777778 6.1 6 1 abnormal cochlea morphology 0.214312758244221 0.479325615556261 0.96066792248945 0.277777777777778 6.1 6 1 abnormal lipid level 0.153141419107785 0.442181404562524 0.95835306002562 0.27710843373494 6.1 6 1 increased double-positive T cell number 0.317201800384316 0.611421525343655 0.954042626472281 0.275862068965517 6.1 6 1 increased retinal apoptosis 0.317201800384316 0.611421525343655 0.954042626472281 0.275862068965517 6.1 6 1 abnormal vertebrae morphology 0.123843352181637 0.387523951491176 0.951854455310647 0.275229357798165 6.1 6 1 abnormal cued conditioning behavior 0.239399319618802 0.503265035664465 0.94936594693075 0.274509803921569 6.1 6 1 impaired hematopoiesis 0.239399319618802 0.503265035664465 0.94936594693075 0.274509803921569 6.1 6 1 increased lung adenocarcinoma incidence 0.239399319618802 0.503265035664465 0.94936594693075 0.274509803921569 6.1 6 1 failure of chorioallantoic fusion 0.239399319618802 0.503265035664465 0.94936594693075 0.274509803921569 6.1 6 1 abnormal dendritic spine morphology 0.239399319618802 0.503265035664465 0.94936594693075 0.274509803921569 6.1 6 1 abnormal gametogenesis 0.270579113259973 0.551015590858929 0.943201232989642 0.272727272727273 6.1 6 1 decreased macrophage cell number 0.270579113259973 0.551015590858929 0.943201232989642 0.272727272727273 6.1 6 1 decreased blood urea nitrogen level 0.270579113259973 0.551015590858929 0.943201232989642 0.272727272727273 6.1 6 1 abnormal long bone epiphysis morphology 0.370015173805868 0.661659596517487 0.943201232989642 0.272727272727273 6.1 6 1 abnormal facial nerve morphology 0.370015173805868 0.661659596517487 0.943201232989642 0.272727272727273 6.1 6 1 intestinal inflammation 0.370015173805868 0.661659596517487 0.943201232989642 0.272727272727273 6.1 6 1 decreased airway responsiveness 0.370015173805868 0.661659596517487 0.943201232989642 0.272727272727273 6.1 6 1 aphakia 0.370015173805868 0.661659596517487 0.943201232989642 0.272727272727273 6.1 6 1 abnormal lysosome physiology 0.370015173805868 0.661659596517487 0.943201232989642 0.272727272727273 6.1 6 1 abnormal female reproductive system physiology 0.370015173805868 0.661659596517487 0.943201232989642 0.272727272727273 6.1 6 1 abnormal limb posture 0.370015173805868 0.661659596517487 0.943201232989642 0.272727272727273 6.1 6 1 increased mammary gland tumor incidence 0.370015173805868 0.661659596517487 0.943201232989642 0.272727272727273 6.1 6 1 impaired humoral immune response 0.370015173805868 0.661659596517487 0.943201232989642 0.272727272727273 6.1 6 1 belly spot 0.312700702542792 0.603974741475218 0.943201232989641 0.272727272727273 6.1 6 1 abnormal skeleton physiology 0.312700702542792 0.603974741475218 0.943201232989641 0.272727272727273 6.1 6 1 decreased systemic arterial blood pressure 0.312700702542792 0.603974741475218 0.943201232989641 0.272727272727273 6.1 6 1 abnormal QRS complex 0.312700702542792 0.603974741475218 0.943201232989641 0.272727272727273 6.1 6 1 cardiovascular system phenotype 0.312700702542792 0.603974741475218 0.943201232989641 0.272727272727273 6.1 6 1 abnormal cardiovascular system morphology 0.267528559042831 0.545473189032002 0.936651224427213 0.270833333333333 6.1 6 1 abnormal long bone metaphysis morphology 0.30814046249347 0.603974741475218 0.934703924584329 0.27027027027027 6.1 6 1 increased insulin secretion 0.30814046249347 0.603974741475218 0.934703924584329 0.27027027027027 6.1 6 1 abnormal excitatory postsynaptic currents 0.204660730258639 0.479325615556261 0.931108909489774 0.269230769230769 6.1 6 1 increased percent body fat/body weight 0.264401116419092 0.539317570391547 0.931108909489774 0.269230769230769 6.1 6 1 abnormal nasal bone morphology 0.362112046370575 0.661659596517487 0.931108909489774 0.269230769230769 6.1 6 1 ventricular hypoplasia 0.362112046370575 0.661659596517487 0.931108909489774 0.269230769230769 6.1 6 1 small seminal vesicle 0.362112046370575 0.661659596517487 0.931108909489774 0.269230769230769 6.1 6 1 abnormal femur morphology 0.230421289065377 0.491993954120279 0.929123602646513 0.26865671641791 6.1 6 1 enhanced paired-pulse facilitation 0.354645899513272 0.661659596517487 0.922241205589872 0.266666666666667 6.1 6 1 abnormal cellular respiration 0.354645899513272 0.661659596517487 0.922241205589872 0.266666666666667 6.1 6 1 lethality at weaning, complete penetrance 0.299074586991974 0.59587347628557 0.922241205589872 0.266666666666667 6.1 6 1 increased anxiety-related response 0.139592345089457 0.411173426181201 0.920582498385573 0.266187050359712 6.1 6 1 decreased food intake 0.223132485650589 0.479325615556261 0.919322720762056 0.265822784810127 6.1 6 1 decreased threshold for auditory brainstem response 0.340854059918008 0.64063050551269 0.910106452884742 0.263157894736842 6.1 6 1 abnormal nail morphology 0.42801293242423 0.697466209895363 0.910106452884742 0.263157894736842 6.1 6 1 decreased tumor incidence 0.42801293242423 0.697466209895363 0.910106452884742 0.263157894736842 6.1 6 1 abnormal digestive system development 0.42801293242423 0.697466209895363 0.910106452884742 0.263157894736842 6.1 6 1 osteoarthritis 0.42801293242423 0.697466209895363 0.910106452884742 0.263157894736842 6.1 6 1 oliguria 0.42801293242423 0.697466209895363 0.910106452884742 0.263157894736842 6.1 6 1 decreased fertilization frequency 0.42801293242423 0.697466209895363 0.910106452884742 0.263157894736842 6.1 6 1 abnormal cartilage morphology 0.334450727227084 0.628833094465133 0.90577261263291 0.261904761904762 6.1 6 1 abnormal blood vessel physiology 0.414726313518379 0.677145851576611 0.902192483729222 0.260869565217391 6.1 6 1 abnormal carpal bone morphology 0.414726313518379 0.677145851576611 0.902192483729222 0.260869565217391 6.1 6 1 abnormal innervation pattern to muscle 0.414726313518379 0.677145851576611 0.902192483729222 0.260869565217391 6.1 6 1 abnormal cardiovascular development 0.414726313518379 0.677145851576611 0.902192483729222 0.260869565217391 6.1 6 1 abnormal sacral vertebrae morphology 0.414726313518379 0.677145851576611 0.902192483729222 0.260869565217391 6.1 6 1 abnormal corneal stroma morphology 0.414726313518379 0.677145851576611 0.902192483729222 0.260869565217391 6.1 6 1 increased susceptibility to fungal infection 0.414726313518379 0.677145851576611 0.902192483729222 0.260869565217391 6.1 6 1 increased susceptibility to pharmacologically induced seizures 0.230364249064969 0.491993954120279 0.900626177333859 0.260416666666667 6.1 6 1 testicular atrophy 0.322471067377211 0.619953723832607 0.899185175450125 0.26 6.1 6 1 abnormal body temperature homeostasis 0.392533240035167 0.661659596517487 0.892491489280521 0.258064516129032 6.1 6 1 abnormal retinal photoreceptor layer morphology 0.392533240035167 0.661659596517487 0.892491489280521 0.258064516129032 6.1 6 1 domed cranium 0.296315907776936 0.590613638297379 0.889304019675948 0.257142857142857 6.1 6 1 decreased triglyceride level 0.382949970834817 0.661659596517487 0.889304019675948 0.257142857142857 6.1 6 1 impaired behavioral response to xenobiotic 0.382949970834817 0.661659596517487 0.889304019675948 0.257142857142857 6.1 6 1 increased vascular permeability 0.374107350106973 0.661659596517487 0.886770389990261 0.256410256410256 6.1 6 1 decreased trabecular bone volume 0.374107350106973 0.661659596517487 0.886770389990261 0.256410256410256 6.1 6 1 increased systemic arterial blood pressure 0.358161953300449 0.661659596517487 0.882996898969026 0.25531914893617 6.1 6 1 abnormal joint morphology 0.344004338087484 0.646307243952127 0.880321150790332 0.254545454545455 6.1 6 1 teratozoospermia 0.319453223483815 0.615522767944222 0.864601130240505 0.25 6.1 6 1 omphalocele 0.397642373333703 0.661659596517487 0.864601130240505 0.25 6.1 6 1 muscular ventricular septal defect 0.363929151439981 0.661659596517487 0.864601130240505 0.25 6.1 6 1 reduced long term potentiation 0.289708288798015 0.577674844396844 0.864601130240505 0.25 6.1 6 1 rib bifurcation 0.443854905644598 0.720214662616398 0.864601130240505 0.25 6.1 6 1 ocular hypertelorism 0.459044428847114 0.743891216128467 0.864601130240505 0.25 6.1 6 1 abnormal primitive streak formation 0.459044428847114 0.743891216128467 0.864601130240505 0.25 6.1 6 1 decreased fatty acid level 0.459044428847114 0.743891216128467 0.864601130240505 0.25 6.1 6 1 decreased circulating phosphate level 0.407642093553315 0.667111649811757 0.864601130240505 0.25 6.1 6 1 abnormal diaphragm morphology 0.43049603553258 0.701282834569282 0.864601130240505 0.25 6.1 6 1 abnormal hearing physiology 0.476772514476514 0.765389886905665 0.864601130240505 0.25 6.1 6 1 decreased paired-pulse facilitation 0.476772514476514 0.765389886905665 0.864601130240505 0.25 6.1 6 1 decreased skin tensile strength 0.476772514476514 0.765389886905665 0.864601130240505 0.25 6.1 6 1 abnormal optic stalk morphology 0.476772514476514 0.765389886905665 0.864601130240505 0.25 6.1 6 1 abnormal postnatal subventricular zone morphology 0.476772514476514 0.765389886905665 0.864601130240505 0.25 6.1 6 1 decreased muscle cell glucose uptake 0.476772514476514 0.765389886905665 0.864601130240505 0.25 6.1 6 1 decreased monocyte cell number 0.382454631326813 0.661659596517487 0.851299574390651 0.246153846153846 6.1 6 1 abnormal male meiosis 0.390713989561324 0.661659596517487 0.850427341220169 0.245901639344262 6.1 6 1 abnormal breathing pattern 0.454004367220483 0.736443341024423 0.841233532125896 0.243243243243243 6.1 6 1 abnormal nest building behavior 0.50246998930542 0.783969668733934 0.830017085030884 0.24 6.1 6 1 diaphragmatic hernia 0.50246998930542 0.783969668733934 0.830017085030884 0.24 6.1 6 1 increased liver glycogen level 0.50246998930542 0.783969668733934 0.830017085030884 0.24 6.1 6 1 small ears 0.524052223654451 0.783969668733934 0.8234296478481 0.238095238095238 6.1 6 1 increased startle reflex 0.436590727753293 0.710978353706263 0.816028033035982 0.235955056179775 6.1 6 1 abnormal retinal photoreceptor morphology 0.505303439152322 0.783969668733934 0.813742240226357 0.235294117647059 6.1 6 1 abnormal spleen red pulp morphology 0.505303439152322 0.783969668733934 0.813742240226357 0.235294117647059 6.1 6 1 abnormal kidney development 0.483355321043819 0.772005858079895 0.806961054891138 0.233333333333333 6.1 6 1 decreased B-1 B cell number 0.523623768748984 0.783969668733934 0.798093350991235 0.230769230769231 6.1 6 1 no spontaneous movement 0.544577372185873 0.80037590151395 0.798093350991235 0.230769230769231 6.1 6 1 abnormal NK cell physiology 0.510950611272647 0.783969668733934 0.793732185138824 0.229508196721311 6.1 6 1 abnormal lymph node morphology 0.523928243200675 0.783969668733934 0.792551036053796 0.229166666666667 6.1 6 1 seizures 0.498009654632417 0.783969668733934 0.788758925833443 0.228070175438596 6.1 6 1 abnormal basisphenoid bone morphology 0.569357238315799 0.823177059174979 0.786001027491368 0.227272727272727 6.1 6 1 increased activated T cell number 0.569357238315799 0.823177059174979 0.786001027491368 0.227272727272727 6.1 6 1 abnormal oogenesis 0.569357238315799 0.823177059174979 0.786001027491368 0.227272727272727 6.1 6 1 increased coping response 0.569357238315799 0.823177059174979 0.786001027491368 0.227272727272727 6.1 6 1 abnormal temporal bone morphology 0.569357238315799 0.823177059174979 0.786001027491368 0.227272727272727 6.1 6 1 abnormal nervous system electrophysiology 0.52598180516853 0.783969668733934 0.782258165455695 0.226190476190476 6.1 6 1 abnormal nose morphology 0.561787781970685 0.819070772473755 0.780930053120456 0.225806451612903 6.1 6 1 abnormal CD8-positive, alpha beta T cell morphology 0.561787781970685 0.819070772473755 0.780930053120456 0.225806451612903 6.1 6 1 preaxial polydactyly 0.561787781970685 0.819070772473755 0.780930053120456 0.225806451612903 6.1 6 1 abnormal spermiogenesis 0.552350055122549 0.810124270116356 0.775159634008728 0.224137931034483 6.1 6 1 decreased osteoclast cell number 0.571332751733493 0.825793271317295 0.76853433799156 0.222222222222222 6.1 6 1 abnormal reflex 0.576708421708445 0.833321056636513 0.76853433799156 0.222222222222222 6.1 6 1 abnormal brain commissure morphology 0.585017395974156 0.842635073819174 0.76853433799156 0.222222222222222 6.1 6 1 abnormal excitatory postsynaptic potential 0.584358584122841 0.84245197660556 0.759161968016053 0.219512195121951 6.1 6 1 abnormal allantois morphology 0.60188695473239 0.865429942136891 0.751827069774352 0.217391304347826 6.1 6 1 abnormal retinal cone cell morphology 0.61231027298175 0.876403319207694 0.751827069774352 0.217391304347826 6.1 6 1 abnormal nasal cavity morphology 0.61231027298175 0.876403319207694 0.751827069774352 0.217391304347826 6.1 6 1 abnormal cochlear ganglion morphology 0.61231027298175 0.876403319207694 0.751827069774352 0.217391304347826 6.1 6 1 abnormal chondrocyte physiology 0.61231027298175 0.876403319207694 0.751827069774352 0.217391304347826 6.1 6 1 abnormal palatal shelf fusion at midline 0.61231027298175 0.876403319207694 0.751827069774352 0.217391304347826 6.1 6 1 abnormal eye physiology 0.606378874007094 0.871636780752758 0.749320979541771 0.216666666666667 6.1 6 1 abnormal response to novel object 0.61279694658915 0.876403319207694 0.745930386874161 0.215686274509804 6.1 6 1 abnormal thrombosis 0.61279694658915 0.876403319207694 0.745930386874161 0.215686274509804 6.1 6 1 abnormal CNS synaptic transmission 0.652688290759716 0.892802927283361 0.733600958991943 0.212121212121212 6.1 6 1 abnormal leukocyte migration 0.640551320628279 0.878859023752258 0.731585571741965 0.211538461538462 6.1 6 1 increased grooming behavior 0.642941239041514 0.881894861933149 0.728085162307793 0.210526315789474 6.1 6 1 abnormal male reproductive system morphology 0.651562151996983 0.89224379471098 0.723852109038562 0.209302325581395 6.1 6 1 small lymph nodes 0.652643389859286 0.892802927283361 0.720500941867087 0.208333333333333 6.1 6 1 hypopigmentation 0.652643389859286 0.892802927283361 0.720500941867087 0.208333333333333 6.1 6 1 abnormal cellular extravasation 0.652643389859286 0.892802927283361 0.720500941867087 0.208333333333333 6.1 6 1 abnormal phalanx morphology 0.659622354614943 0.901885121706885 0.720500941867087 0.208333333333333 6.1 6 1 abnormal parietal bone morphology 0.659871727238807 0.901885121706885 0.715531969854211 0.206896551724138 6.1 6 1 absent long term depression 0.659871727238807 0.901885121706885 0.715531969854211 0.206896551724138 6.1 6 1 abnormal bone remodeling 0.666920130326388 0.911268236301505 0.712024460198063 0.205882352941176 6.1 6 1 abnormal photoreceptor outer segment morphology 0.680295472091349 0.929288845045156 0.707400924742231 0.204545454545455 6.1 6 1 abnormal synaptic transmission 0.693947405439294 0.941731680867563 0.691680904192404 0.2 6.1 6 1 enhanced long term potentiation 0.739947427541679 0.98271181313931 0.679329459474682 0.196428571428571 6.1 6 1 abnormal systemic arterial blood pressure 0.727601380856693 0.968124329971128 0.672467545742615 0.194444444444444 6.1 6 1 abnormal kidney cortex morphology 0.724855637095819 0.964987100495504 0.665077792492696 0.192307692307692 6.1 6 1 enhanced coordination 0.785576359567219 1 0.617572235886075 0.178571428571429 6.1 6 1 abnormal social investigation 0.885968316706453 1 0.605220791168353 0.175 6.1 6 1 focal hair loss 0.811764824635638 1 0.596276641545176 0.172413793103448 6.1 6 1 arrested T cell differentiation 0.835328308474907 1 0.57640075349367 0.166666666666667 6.1 6 1 abnormal inhibitory postsynaptic currents 0.9212269122573 1 0.559447790155621 0.161764705882353 6.1 6 1 impaired natural killer cell mediated cytotoxicity 0.918272371663701 1 0.546063871730845 0.157894736842105 6.1 6 1 aorta coarctation 8.58648587155465e-05 0.00134332601292404 2.80868979454362 1 7.1 7 1 thick pulmonary valve 8.58648587155465e-05 0.00134332601292404 2.80868979454362 1 7.1 7 1 absent neurocranium 0.00124670110503289 0.0122818574208686 2.80868979454362 1 7.1 7 1 abnormal pineal gland morphology 0.00124670110503289 0.0122818574208686 2.80868979454362 1 7.1 7 1 increased heart right ventricle weight 0.00124670110503289 0.0122818574208686 2.80868979454362 1 7.1 7 1 decreased QRS amplitude 0.00124670110503289 0.0122818574208686 2.80868979454362 1 7.1 7 1 ventricular myocardium compact layer hypoplasia 0.00124670110503289 0.0122818574208686 2.80868979454362 1 7.1 7 1 increased Schwann cell number 0.00124670110503289 0.0122818574208686 2.80868979454362 1 7.1 7 1 abnormal right lung morphology 0.000327195177835514 0.00422804158371866 2.80868979454362 1 7.1 7 1 abnormal aorta tunica adventitia morphology 0.000327195177835514 0.00422804158371866 2.80868979454362 1 7.1 7 1 abnormal olfactory bulb layer morphology 0.000327195177835514 0.00422804158371866 2.80868979454362 1 7.1 7 1 abnormal soleus morphology 1.05162815305361e-06 2.79778078151962e-05 2.59263673342488 0.923076923076923 7.1 7 1 muscle fatigue 1.05162815305361e-06 2.79778078151962e-05 2.59263673342488 0.923076923076923 7.1 7 1 thick aortic valve 4.5159233929726e-05 0.000819953243797032 2.52782081508926 0.9 7.1 7 1 prolonged QRS complex duration 4.04742231448291e-12 3.19934450068883e-10 2.50775874512823 0.892857142857143 7.1 7 1 abnormal cardiac muscle contractility 5.33966820329981e-10 3.08893596644379e-08 2.45760357022567 0.875 7.1 7 1 decreased aerobic running capacity 0.00052919912157511 0.00599718822286144 2.45760357022567 0.875 7.1 7 1 abnormal cerebellum deep nucleus morphology 0.00052919912157511 0.00599718822286144 2.45760357022567 0.875 7.1 7 1 abnormal brain ependyma morphology 0.00052919912157511 0.00599718822286144 2.45760357022567 0.875 7.1 7 1 abnormal anterior commissure pars posterior morphology 0.00052919912157511 0.00599718822286144 2.45760357022567 0.875 7.1 7 1 abnormal heart echocardiography feature 0.00052919912157511 0.00599718822286144 2.45760357022567 0.875 7.1 7 1 prolonged PQ interval 0.00052919912157511 0.00599718822286144 2.45760357022567 0.875 7.1 7 1 embryo cyst 0.00052919912157511 0.00599718822286144 2.45760357022567 0.875 7.1 7 1 cellular necrosis 0.00177517709255532 0.0160865319407335 2.4074483953231 0.857142857142857 7.1 7 1 abnormal gastrulation movements 0.00177517709255532 0.0160865319407335 2.4074483953231 0.857142857142857 7.1 7 1 skeletal muscle interstitial fibrosis 0.00177517709255532 0.0160865319407335 2.4074483953231 0.857142857142857 7.1 7 1 small tail bud 0.00177517709255532 0.0160865319407335 2.4074483953231 0.857142857142857 7.1 7 1 absent myocardial trabeculae 1.83226429341185e-05 0.000363167922698165 2.37658367230614 0.846153846153846 7.1 7 1 hematuria 5.94115041944545e-05 0.00101571214215605 2.34057482878635 0.833333333333333 7.1 7 1 thin tail 0.00584423074101978 0.0390269099819777 2.34057482878635 0.833333333333333 7.1 7 1 sparse vibrissae 0.00584423074101978 0.0390269099819777 2.34057482878635 0.833333333333333 7.1 7 1 delayed brain development 0.00584423074101978 0.0390269099819777 2.34057482878635 0.833333333333333 7.1 7 1 abnormal gustatory system physiology 0.00584423074101978 0.0390269099819777 2.34057482878635 0.833333333333333 7.1 7 1 chromatolysis 0.00584423074101978 0.0390269099819777 2.34057482878635 0.833333333333333 7.1 7 1 abnormal ST segment 0.00584423074101978 0.0390269099819777 2.34057482878635 0.833333333333333 7.1 7 1 absent parietal bone 0.00584423074101978 0.0390269099819777 2.34057482878635 0.833333333333333 7.1 7 1 abnormal thromboxane level 0.00584423074101978 0.0390269099819777 2.34057482878635 0.833333333333333 7.1 7 1 abnormal orbit morphology 0.00584423074101978 0.0390269099819777 2.34057482878635 0.833333333333333 7.1 7 1 enlarged lymphatic vessel 0.00584423074101978 0.0390269099819777 2.34057482878635 0.833333333333333 7.1 7 1 abnormal heart right ventricle outflow tract morphology 0.00584423074101978 0.0390269099819777 2.34057482878635 0.833333333333333 7.1 7 1 increased total lung capacity 0.00584423074101978 0.0390269099819777 2.34057482878635 0.833333333333333 7.1 7 1 thymus cortex atrophy 0.00584423074101978 0.0390269099819777 2.34057482878635 0.833333333333333 7.1 7 1 pharyngeal arch hypoplasia 0.000189909505904625 0.00264649801645801 2.29801892280841 0.818181818181818 7.1 7 1 common atrioventricular valve 0.000189909505904625 0.00264649801645801 2.29801892280841 0.818181818181818 7.1 7 1 increased heart left ventricle size 6.79742878728155e-06 0.00014832108866985 2.28206045806669 0.8125 7.1 7 1 increased skin tumor incidence 7.89240531537393e-07 2.23094979795371e-05 2.24695183563489 0.8 7.1 7 1 abnormal heart electrocardiography waveform feature 7.89240531537393e-07 2.23094979795371e-05 2.24695183563489 0.8 7.1 7 1 abnormal tibialis anterior morphology 0.000596801072760687 0.00652546227908663 2.24695183563489 0.8 7.1 7 1 abnormal gas homeostasis 0.000596801072760687 0.00652546227908663 2.24695183563489 0.8 7.1 7 1 osteosclerosis 0.000596801072760687 0.00652546227908663 2.24695183563489 0.8 7.1 7 1 increased circulating fructosamine level 0.000596801072760687 0.00652546227908663 2.24695183563489 0.8 7.1 7 1 thin ventricle myocardium compact layer 0.000596801072760687 0.00652546227908663 2.24695183563489 0.8 7.1 7 1 abnormal adaptive thermogenesis 0.000596801072760687 0.00652546227908663 2.24695183563489 0.8 7.1 7 1 increased hemangioma incidence 6.50368731468492e-05 0.00108213526389824 2.20682769571284 0.785714285714286 7.1 7 1 increased pulmonary respiratory rate 6.50368731468492e-05 0.00108213526389824 2.20682769571284 0.785714285714286 7.1 7 1 cardiomyopathy 7.6073530921432e-13 7.00862622840971e-11 2.18453650686726 0.777777777777778 7.1 7 1 heart hyperplasia 0.00183718944115228 0.0164388803412457 2.18453650686726 0.777777777777778 7.1 7 1 shortened ST segment 0.00183718944115228 0.0164388803412457 2.18453650686726 0.777777777777778 7.1 7 1 abnormal pulmonary alveolar system morphology 0.00183718944115228 0.0164388803412457 2.18453650686726 0.777777777777778 7.1 7 1 abnormal ductus venosus valve topology 0.00183718944115228 0.0164388803412457 2.18453650686726 0.777777777777778 7.1 7 1 abnormal infrahyoid muscle connection 0.00183718944115228 0.0164388803412457 2.18453650686726 0.777777777777778 7.1 7 1 increased cardiac muscle glycogen level 0.00183718944115228 0.0164388803412457 2.18453650686726 0.777777777777778 7.1 7 1 ventricular hypoplasia 9.84163493976247e-08 3.52245567088621e-06 2.1605306111874 0.769230769230769 7.1 7 1 axonal dystrophy 0.000196374375062241 0.00272894557523645 2.1605306111874 0.769230769230769 7.1 7 1 absent segment of posterior cerebral artery 2.50057891553005e-06 6.26478445147076e-05 2.13995412917609 0.761904761904762 7.1 7 1 impaired skeletal muscle contractility 4.807574707462e-10 2.81384519642629e-08 2.12549497965463 0.756756756756757 7.1 7 1 abnormal heart right ventricle morphology 7.31434360968484e-06 0.000156175362481468 2.10651734590771 0.75 7.1 7 1 absent ductus venosus valve 7.31434360968484e-06 0.000156175362481468 2.10651734590771 0.75 7.1 7 1 abnormal impulse conducting system conduction 8.46433077984816e-07 2.32652185799694e-05 2.10651734590771 0.75 7.1 7 1 prolonged QT interval 8.46433077984816e-07 2.32652185799694e-05 2.10651734590771 0.75 7.1 7 1 abnormal truncus arteriosus septation 8.46433077984816e-07 2.32652185799694e-05 2.10651734590771 0.75 7.1 7 1 increased osteosarcoma incidence 0.000581403511035135 0.00645643407901741 2.10651734590771 0.75 7.1 7 1 abnormal fatty acid level 0.000581403511035135 0.00645643407901741 2.10651734590771 0.75 7.1 7 1 increased skeletal muscle glycogen level 0.000581403511035135 0.00645643407901741 2.10651734590771 0.75 7.1 7 1 prenatal growth retardation 0.000581403511035135 0.00645643407901741 2.10651734590771 0.75 7.1 7 1 enlarged pituitary gland 0.00551311100549595 0.0374695727491016 2.10651734590771 0.75 7.1 7 1 increased sensitivity to skin irradiation 0.00551311100549595 0.0374695727491016 2.10651734590771 0.75 7.1 7 1 colon polyps 0.00551311100549595 0.0374695727491016 2.10651734590771 0.75 7.1 7 1 binucleate 0.00551311100549595 0.0374695727491016 2.10651734590771 0.75 7.1 7 1 absent interparietal bone 0.00551311100549595 0.0374695727491016 2.10651734590771 0.75 7.1 7 1 abnormal somite size 0.00551311100549595 0.0374695727491016 2.10651734590771 0.75 7.1 7 1 abnormal olfactory bulb mitral cell layer morphology 0.00551311100549595 0.0374695727491016 2.10651734590771 0.75 7.1 7 1 sinoatrial block 0.00551311100549595 0.0374695727491016 2.10651734590771 0.75 7.1 7 1 increased circulating ferritin level 0.00551311100549595 0.0374695727491016 2.10651734590771 0.75 7.1 7 1 absent hypoglossal canal 0.00551311100549595 0.0374695727491016 2.10651734590771 0.75 7.1 7 1 retropleural edema 0.00551311100549595 0.0374695727491016 2.10651734590771 0.75 7.1 7 1 abnormal umbilical vein topology 0.00551311100549595 0.0374695727491016 2.10651734590771 0.75 7.1 7 1 decreased white adipose tissue mass 0.00551311100549595 0.0374695727491016 2.10651734590771 0.75 7.1 7 1 cardiac fibrosis 4.02778052182439e-20 1.05464253137244e-17 2.08173478889703 0.741176470588235 7.1 7 1 thick interventricular septum 2.85285745279232e-07 8.98288976433023e-06 2.0805109589212 0.740740740740741 7.1 7 1 delayed intramembranous bone ossification 0.000185643895880389 0.00260162924508433 2.05970584933199 0.733333333333333 7.1 7 1 abnormal coronary vessel morphology 0.000185643895880389 0.00260162924508433 2.05970584933199 0.733333333333333 7.1 7 1 heterochrony 0.000185643895880389 0.00260162924508433 2.05970584933199 0.733333333333333 7.1 7 1 increased cardiomyocyte apoptosis 3.22075642187604e-08 1.25181743740885e-06 2.04268348694081 0.727272727272727 7.1 7 1 prolonged PR interval 6.91947944974483e-06 0.00015032493564402 2.04268348694081 0.727272727272727 7.1 7 1 premature suture closure 0.00168184525104352 0.0154661370128309 2.04268348694081 0.727272727272727 7.1 7 1 abnormal sphenoid bone morphology 0.00168184525104352 0.0154661370128309 2.04268348694081 0.727272727272727 7.1 7 1 abnormal eye distance/ position 0.00168184525104352 0.0154661370128309 2.04268348694081 0.727272727272727 7.1 7 1 abnormal proximal-distal axis patterning 0.00168184525104352 0.0154661370128309 2.04268348694081 0.727272727272727 7.1 7 1 abnormal radial glial cell morphology 0.00168184525104352 0.0154661370128309 2.04268348694081 0.727272727272727 7.1 7 1 abnormal palatal shelf elevation 0.00168184525104352 0.0154661370128309 2.04268348694081 0.727272727272727 7.1 7 1 aorta dilation 0.00168184525104352 0.0154661370128309 2.04268348694081 0.727272727272727 7.1 7 1 reduced sympathetic cervical ganglion size 0.00168184525104352 0.0154661370128309 2.04268348694081 0.727272727272727 7.1 7 1 increased mortality induced by gamma-irradiation 2.69956754617557e-07 8.55436212880476e-06 2.03387881673848 0.724137931034483 7.1 7 1 increased circulating renin level 5.97409641540054e-05 0.00101784690639102 2.02849818494817 0.722222222222222 7.1 7 1 midline facial cleft 0.000524718129850721 0.00599718822286144 2.00620699610258 0.714285714285714 7.1 7 1 absent atrioventricular cushions 0.000524718129850721 0.00599718822286144 2.00620699610258 0.714285714285714 7.1 7 1 skeletal muscle necrosis 0.000524718129850721 0.00599718822286144 2.00620699610258 0.714285714285714 7.1 7 1 testis degeneration 0.000524718129850721 0.00599718822286144 2.00620699610258 0.714285714285714 7.1 7 1 multiple persisting craniopharyngeal ducts 0.000524718129850721 0.00599718822286144 2.00620699610258 0.714285714285714 7.1 7 1 abnormal vitelline vein topology 0.000524718129850721 0.00599718822286144 2.00620699610258 0.714285714285714 7.1 7 1 excessive tearing 0.0160168648621809 0.0867071846456475 2.00620699610258 0.714285714285714 7.1 7 1 abnormal tumor incidence 0.0160168648621809 0.0867071846456475 2.00620699610258 0.714285714285714 7.1 7 1 decreased cardiomyocyte apoptosis 0.0160168648621809 0.0867071846456475 2.00620699610258 0.714285714285714 7.1 7 1 utricular macular degeneration 0.0160168648621809 0.0867071846456475 2.00620699610258 0.714285714285714 7.1 7 1 abnormal renal/urinary system physiology 0.0160168648621809 0.0867071846456475 2.00620699610258 0.714285714285714 7.1 7 1 decreased tidal volume 0.0160168648621809 0.0867071846456475 2.00620699610258 0.714285714285714 7.1 7 1 uremia 0.0160168648621809 0.0867071846456475 2.00620699610258 0.714285714285714 7.1 7 1 abnormal spinal cord central canal morphology 0.0160168648621809 0.0867071846456475 2.00620699610258 0.714285714285714 7.1 7 1 heart hemorrhage 0.0160168648621809 0.0867071846456475 2.00620699610258 0.714285714285714 7.1 7 1 decreased DN2 thymocyte number 0.0160168648621809 0.0867071846456475 2.00620699610258 0.714285714285714 7.1 7 1 decreased brain cholesterol level 0.0160168648621809 0.0867071846456475 2.00620699610258 0.714285714285714 7.1 7 1 decreased skeletal muscle glycogen level 0.0160168648621809 0.0867071846456475 2.00620699610258 0.714285714285714 7.1 7 1 abnormal T wave 0.0160168648621809 0.0867071846456475 2.00620699610258 0.714285714285714 7.1 7 1 abnormal conotruncal ridge morphology 0.0160168648621809 0.0867071846456475 2.00620699610258 0.714285714285714 7.1 7 1 abnormal aortic valve cusp morphology 0.0160168648621809 0.0867071846456475 2.00620699610258 0.714285714285714 7.1 7 1 thick mitral valve cusps 0.0160168648621809 0.0867071846456475 2.00620699610258 0.714285714285714 7.1 7 1 altered tumor pathology 0.0160168648621809 0.0867071846456475 2.00620699610258 0.714285714285714 7.1 7 1 dilated pulmonary alveolar ducts 0.0160168648621809 0.0867071846456475 2.00620699610258 0.714285714285714 7.1 7 1 embryonic lethality at implantation, incomplete penetrance 0.0160168648621809 0.0867071846456475 2.00620699610258 0.714285714285714 7.1 7 1 ductus venosus stenosis 0.0160168648621809 0.0867071846456475 2.00620699610258 0.714285714285714 7.1 7 1 abnormal Mullerian duct topology 0.0160168648621809 0.0867071846456475 2.00620699610258 0.714285714285714 7.1 7 1 fragmented Meckel's cartilage 0.0160168648621809 0.0867071846456475 2.00620699610258 0.714285714285714 7.1 7 1 embryo tumor 0.0160168648621809 0.0867071846456475 2.00620699610258 0.714285714285714 7.1 7 1 decreased glycogen level 2.99454539718983e-08 1.17306010637948e-06 2.00620699610258 0.714285714285714 7.1 7 1 increased muscle cell glucose uptake 1.93487553450716e-05 0.000380474536923839 2.00620699610258 0.714285714285714 7.1 7 1 decreased cardiac muscle contractility 1.31441352846805e-21 4.28140458608539e-19 1.99849081534834 0.711538461538462 7.1 7 1 pericardial effusion 2.35963629452212e-13 2.30180207161716e-11 1.99326372515999 0.709677419354839 7.1 7 1 thick ventricular wall 3.33103517175216e-09 1.60892232810359e-07 1.9866342449211 0.707317073170732 7.1 7 1 abnormal brown adipose tissue morphology 8.20993693705515e-08 2.98134571254375e-06 1.98260456085432 0.705882352941177 7.1 7 1 abnormal interatrial septum morphology 0.000166177634129253 0.00238940384333247 1.98260456085432 0.705882352941177 7.1 7 1 abnormal vagus nerve morphology 0.000166177634129253 0.00238940384333247 1.98260456085432 0.705882352941177 7.1 7 1 abnormal dorsal-ventral axis patterning 0.000166177634129253 0.00238940384333247 1.98260456085432 0.705882352941177 7.1 7 1 coloboma 0.000166177634129253 0.00238940384333247 1.98260456085432 0.705882352941177 7.1 7 1 increased trabecular bone mass 0.000166177634129253 0.00238940384333247 1.98260456085432 0.705882352941177 7.1 7 1 increased urine glucose level 5.31947771502852e-05 0.00092532872840094 1.96608285618053 0.7 7.1 7 1 increased cranium width 0.00473142896739933 0.0336618350542409 1.96608285618053 0.7 7.1 7 1 abnormal mammary gland physiology 0.00473142896739933 0.0336618350542409 1.96608285618053 0.7 7.1 7 1 ketoaciduria 0.00473142896739933 0.0336618350542409 1.96608285618053 0.7 7.1 7 1 acrania 0.00473142896739933 0.0336618350542409 1.96608285618053 0.7 7.1 7 1 aneurysm 0.00473142896739933 0.0336618350542409 1.96608285618053 0.7 7.1 7 1 bifid ureter 0.00473142896739933 0.0336618350542409 1.96608285618053 0.7 7.1 7 1 increased atrioventricular cushion size 0.00473142896739933 0.0336618350542409 1.96608285618053 0.7 7.1 7 1 increased platelet aggregation 0.00473142896739933 0.0336618350542409 1.96608285618053 0.7 7.1 7 1 decreased transitional stage T2 B cell number 0.00473142896739933 0.0336618350542409 1.96608285618053 0.7 7.1 7 1 abnormal hippocampus neuron morphology 0.00473142896739933 0.0336618350542409 1.96608285618053 0.7 7.1 7 1 abnormal inferior vena cava valve morphology 0.00473142896739933 0.0336618350542409 1.96608285618053 0.7 7.1 7 1 thick aortic valve cusps 0.00473142896739933 0.0336618350542409 1.96608285618053 0.7 7.1 7 1 decreased macrophage apoptosis 0.00473142896739933 0.0336618350542409 1.96608285618053 0.7 7.1 7 1 decreased circulating lactate level 0.00473142896739933 0.0336618350542409 1.96608285618053 0.7 7.1 7 1 dilated heart atrium 2.22536601634268e-07 7.23607577209467e-06 1.95757167498495 0.696969696969697 7.1 7 1 absent teeth 0.00144771906697415 0.0138774611911298 1.94447755006866 0.692307692307692 7.1 7 1 absent trabeculae carneae 0.00144771906697415 0.0138774611911298 1.94447755006866 0.692307692307692 7.1 7 1 dystrophic cardiac calcinosis 0.00144771906697415 0.0138774611911298 1.94447755006866 0.692307692307692 7.1 7 1 abnormal tail bud morphology 0.00144771906697415 0.0138774611911298 1.94447755006866 0.692307692307692 7.1 7 1 abnormal aorta tunica media morphology 0.00144771906697415 0.0138774611911298 1.94447755006866 0.692307692307692 7.1 7 1 absent hypoglossal nerve 0.00144771906697415 0.0138774611911298 1.94447755006866 0.692307692307692 7.1 7 1 abnormal heart atrium morphology 5.9589257949597e-07 1.75418081833873e-05 1.93097423374874 0.6875 7.1 7 1 poor circulation 0.000452541485868361 0.00542895239865676 1.93097423374874 0.6875 7.1 7 1 impaired muscle relaxation 0.000452541485868361 0.00542895239865676 1.93097423374874 0.6875 7.1 7 1 decreased liver cholesterol level 0.000452541485868361 0.00542895239865676 1.93097423374874 0.6875 7.1 7 1 decreased adipocyte glucose uptake 0.000452541485868361 0.00542895239865676 1.93097423374874 0.6875 7.1 7 1 decreased triglyceride level 1.95889730240341e-07 6.49700938630466e-06 1.92595871625848 0.685714285714286 7.1 7 1 abnormal muscle physiology 8.43671361465349e-17 1.23448971273239e-14 1.92505705019282 0.685393258426966 7.1 7 1 abnormal apoptosis 9.85089228897913e-11 6.1260236422089e-09 1.92447263700211 0.685185185185185 7.1 7 1 increased circulating creatine kinase level 4.59829179779146e-05 0.000831872788873182 1.91501576900701 0.681818181818182 7.1 7 1 subcutaneous edema 4.82416123572162e-06 0.000112150477325771 1.90589664629745 0.678571428571429 7.1 7 1 malocclusion 1.6973318458954e-07 5.74437138321744e-06 1.89776337469163 0.675675675675676 7.1 7 1 cardiac hypertrophy 1.91197342800662e-17 3.39716707297606e-15 1.89156659632529 0.673469387755102 7.1 7 1 abnormal heart tube morphology 4.10419456317695e-06 9.72303235800254e-05 1.87245986302908 0.666666666666667 7.1 7 1 disorganized myocardium 4.10419456317695e-06 9.72303235800254e-05 1.87245986302908 0.666666666666667 7.1 7 1 trunk curl 0.000120886820760712 0.00183918022411175 1.87245986302908 0.666666666666667 7.1 7 1 abnormal mitral valve morphology 0.00037905097407975 0.00477412302796646 1.87245986302908 0.666666666666667 7.1 7 1 darkened coat color 0.00037905097407975 0.00477412302796646 1.87245986302908 0.666666666666667 7.1 7 1 increased gastrointestinal tumor incidence 0.00037905097407975 0.00477412302796646 1.87245986302908 0.666666666666667 7.1 7 1 atrioventricular block 0.00037905097407975 0.00477412302796646 1.87245986302908 0.666666666666667 7.1 7 1 herniated liver 0.00120286659779139 0.0120407672515335 1.87245986302908 0.666666666666667 7.1 7 1 impaired embryo implantation 0.00388272873106029 0.0298095299954089 1.87245986302908 0.666666666666667 7.1 7 1 myocarditis 0.00388272873106029 0.0298095299954089 1.87245986302908 0.666666666666667 7.1 7 1 increased papilloma incidence 0.00388272873106029 0.0298095299954089 1.87245986302908 0.666666666666667 7.1 7 1 abnormal gastrocnemius morphology 0.00388272873106029 0.0298095299954089 1.87245986302908 0.666666666666667 7.1 7 1 decreased left ventricle systolic pressure 0.00388272873106029 0.0298095299954089 1.87245986302908 0.666666666666667 7.1 7 1 pale placenta 0.00388272873106029 0.0298095299954089 1.87245986302908 0.666666666666667 7.1 7 1 stria vascularis degeneration 0.00388272873106029 0.0298095299954089 1.87245986302908 0.666666666666667 7.1 7 1 abnormal aorta elastic tissue morphology 0.00388272873106029 0.0298095299954089 1.87245986302908 0.666666666666667 7.1 7 1 abnormal pulmonary valve cusp morphology 0.00388272873106029 0.0298095299954089 1.87245986302908 0.666666666666667 7.1 7 1 abnormal vitelline vein connection 0.00388272873106029 0.0298095299954089 1.87245986302908 0.666666666666667 7.1 7 1 abnormal artery development 0.0128649541341833 0.0746827850846695 1.87245986302908 0.666666666666667 7.1 7 1 abnormal thymus physiology 0.0128649541341833 0.0746827850846695 1.87245986302908 0.666666666666667 7.1 7 1 decreased cellular sensitivity to ionizing radiation 0.0128649541341833 0.0746827850846695 1.87245986302908 0.666666666666667 7.1 7 1 increased tidal volume 0.0128649541341833 0.0746827850846695 1.87245986302908 0.666666666666667 7.1 7 1 decreased transitional stage T1 B cell number 0.0128649541341833 0.0746827850846695 1.87245986302908 0.666666666666667 7.1 7 1 abnormal incisor color 0.0128649541341833 0.0746827850846695 1.87245986302908 0.666666666666667 7.1 7 1 iris coloboma 0.0128649541341833 0.0746827850846695 1.87245986302908 0.666666666666667 7.1 7 1 abnormal heart left ventricle pressure 0.0128649541341833 0.0746827850846695 1.87245986302908 0.666666666666667 7.1 7 1 cerebellum atrophy 0.0128649541341833 0.0746827850846695 1.87245986302908 0.666666666666667 7.1 7 1 abnormal diaphragm morphology 3.44391886841985e-06 8.27705138666123e-05 1.84320267766925 0.65625 7.1 7 1 lordosis 1.05344267219669e-05 0.000220204928326829 1.8401760722872 0.655172413793103 7.1 7 1 abnormal Mullerian duct morphology 3.23688030663971e-05 0.000607678472661605 1.83645101950929 0.653846153846154 7.1 7 1 dilated heart 0.000100016046421086 0.00154049483264675 1.83175421383279 0.652173913043478 7.1 7 1 abnormal hematopoietic stem cell physiology 0.000100016046421086 0.00154049483264675 1.83175421383279 0.652173913043478 7.1 7 1 increased mammary adenocarcinoma incidence 0.00031123739538369 0.00406405785310724 1.82564836645335 0.65 7.1 7 1 anencephaly 0.00031123739538369 0.00406405785310724 1.82564836645335 0.65 7.1 7 1 abnormal myocardial fiber morphology 1.49133593945529e-15 2.00524224291623e-13 1.82420058820874 0.649484536082474 7.1 7 1 small lung 9.45395367064555e-09 4.23724500103258e-07 1.81738751411646 0.647058823529412 7.1 7 1 abnormal bone marrow cavity morphology 0.00097754188072339 0.0100897735614084 1.81738751411646 0.647058823529412 7.1 7 1 decreased vasoconstriction 0.00097754188072339 0.0100897735614084 1.81738751411646 0.647058823529412 7.1 7 1 increased brain size 0.00097754188072339 0.0100897735614084 1.81738751411646 0.647058823529412 7.1 7 1 enhanced behavioral response to cocaine 0.00097754188072339 0.0100897735614084 1.81738751411646 0.647058823529412 7.1 7 1 overriding aortic valve 2.84038528739542e-08 1.12150133371367e-06 1.81394549230942 0.645833333333333 7.1 7 1 abnormal myocardium layer morphology 1.03516333271796e-12 9.36352287322152e-11 1.81320480407246 0.645569620253165 7.1 7 1 decreased double-negative T cell number 8.70290901201951e-06 0.000184242435467222 1.81205793196362 0.645161290322581 7.1 7 1 small superior cervical ganglion 2.65988444308808e-05 0.000508958657860122 1.80558629649233 0.642857142857143 7.1 7 1 abnormal placing response 0.00310912075379631 0.0253097182193544 1.80558629649233 0.642857142857143 7.1 7 1 abnormal heart left ventricle morphology 2.26975212624352e-11 1.5683356705641e-09 1.79444070206953 0.638888888888889 7.1 7 1 decreased atrioventricular cushion size 0.010068200471022 0.0613088094777656 1.78734805107321 0.636363636363636 7.1 7 1 abnormal food preference 0.010068200471022 0.0613088094777656 1.78734805107321 0.636363636363636 7.1 7 1 abnormal bronchiole morphology 0.010068200471022 0.0613088094777656 1.78734805107321 0.636363636363636 7.1 7 1 fatigue 0.010068200471022 0.0613088094777656 1.78734805107321 0.636363636363636 7.1 7 1 abnormal crista ampullaris neuroepithelium morphology 0.010068200471022 0.0613088094777656 1.78734805107321 0.636363636363636 7.1 7 1 abnormal spinal cord ventral horn morphology 0.010068200471022 0.0613088094777656 1.78734805107321 0.636363636363636 7.1 7 1 abnormal palate development 0.010068200471022 0.0613088094777656 1.78734805107321 0.636363636363636 7.1 7 1 aberrant origin of the right subclavian artery 0.010068200471022 0.0613088094777656 1.78734805107321 0.636363636363636 7.1 7 1 enlarged adrenal glands 0.000782836026447358 0.00831874814484683 1.77390934392228 0.631578947368421 7.1 7 1 oliguria 0.000782836026447358 0.00831874814484683 1.77390934392228 0.631578947368421 7.1 7 1 increased left ventricle weight 0.000782836026447358 0.00831874814484683 1.77390934392228 0.631578947368421 7.1 7 1 embryonic lethality between implantation and somite formation, incomplete penetrance 0.000782836026447358 0.00831874814484683 1.77390934392228 0.631578947368421 7.1 7 1 failure to gastrulate 1.73062004002694e-07 5.77841254975439e-06 1.77069574003837 0.630434782608696 7.1 7 1 atrial septal defect 1.73062004002694e-07 5.77841254975439e-06 1.77069574003837 0.630434782608696 7.1 7 1 abnormal fetal cardiomyocyte proliferation 6.59743508100559e-05 0.00109407465093343 1.76843431508302 0.62962962962963 7.1 7 1 abnormal embryonic epiblast morphology 5.78144452568416e-06 0.000130739484160358 1.76546215657027 0.628571428571429 7.1 7 1 abnormal spongiotrophoblast layer morphology 1.74678925846855e-05 0.000349007090798436 1.75543112158976 0.625 7.1 7 1 disorganized yolk sac vascular plexus 0.00245340845099642 0.0207580051763728 1.75543112158976 0.625 7.1 7 1 abnormal epicardium morphology 0.00245340845099642 0.0207580051763728 1.75543112158976 0.625 7.1 7 1 kidney degeneration 0.00245340845099642 0.0207580051763728 1.75543112158976 0.625 7.1 7 1 impaired behavioral response to addictive substance 0.00245340845099642 0.0207580051763728 1.75543112158976 0.625 7.1 7 1 schistocytosis 0.0335231212899892 0.147070130879803 1.75543112158976 0.625 7.1 7 1 abnormal cecum morphology 0.0335231212899892 0.147070130879803 1.75543112158976 0.625 7.1 7 1 clubfoot 0.0335231212899892 0.147070130879803 1.75543112158976 0.625 7.1 7 1 absent mammary gland 0.0335231212899892 0.147070130879803 1.75543112158976 0.625 7.1 7 1 absent skin pigmentation 0.0335231212899892 0.147070130879803 1.75543112158976 0.625 7.1 7 1 dermal cysts 0.0335231212899892 0.147070130879803 1.75543112158976 0.625 7.1 7 1 absent eyelids 0.0335231212899892 0.147070130879803 1.75543112158976 0.625 7.1 7 1 unidirectional circling 0.0335231212899892 0.147070130879803 1.75543112158976 0.625 7.1 7 1 poor grooming 0.0335231212899892 0.147070130879803 1.75543112158976 0.625 7.1 7 1 abnormal urination 0.0335231212899892 0.147070130879803 1.75543112158976 0.625 7.1 7 1 short ureter 0.0335231212899892 0.147070130879803 1.75543112158976 0.625 7.1 7 1 absent tympanic ring 0.0335231212899892 0.147070130879803 1.75543112158976 0.625 7.1 7 1 early eyelid opening 0.0335231212899892 0.147070130879803 1.75543112158976 0.625 7.1 7 1 abnormal kidney epithelium morphology 0.0335231212899892 0.147070130879803 1.75543112158976 0.625 7.1 7 1 increased pulmonary ventilation 0.0335231212899892 0.147070130879803 1.75543112158976 0.625 7.1 7 1 abnormal meiotic spindle morphology 0.0335231212899892 0.147070130879803 1.75543112158976 0.625 7.1 7 1 abnormal olfactory bulb glomerular layer morphology 0.0335231212899892 0.147070130879803 1.75543112158976 0.625 7.1 7 1 decreased quadriceps weight 0.0335231212899892 0.147070130879803 1.75543112158976 0.625 7.1 7 1 pleural effusion 0.0335231212899892 0.147070130879803 1.75543112158976 0.625 7.1 7 1 increased heart right ventricle size 0.0335231212899892 0.147070130879803 1.75543112158976 0.625 7.1 7 1 decreased alveolar lamellar body number 0.0335231212899892 0.147070130879803 1.75543112158976 0.625 7.1 7 1 lethality during fetal growth through weaning, incomplete penetrance 0.0335231212899892 0.147070130879803 1.75543112158976 0.625 7.1 7 1 impaired neuron differentiation 0.0335231212899892 0.147070130879803 1.75543112158976 0.625 7.1 7 1 increased cornea thickness 0.0335231212899892 0.147070130879803 1.75543112158976 0.625 7.1 7 1 decreased basal metabolism 0.0335231212899892 0.147070130879803 1.75543112158976 0.625 7.1 7 1 trabecula carnea hypoplasia 4.19746730615121e-07 1.25797589446399e-05 1.74762920549381 0.622222222222222 7.1 7 1 irregular heartbeat 4.19746730615121e-07 1.25797589446399e-05 1.74762920549381 0.622222222222222 7.1 7 1 blood in lymph vessels 5.28860734091034e-05 0.000923186720036103 1.74332470006156 0.620689655172414 7.1 7 1 abnormal interventricular septum morphology 1.13823127007108e-07 4.01609969404513e-06 1.74138767261704 0.62 7.1 7 1 abnormal skeletal muscle fiber morphology 2.65648766795996e-10 1.5922923070001e-08 1.74059649239323 0.619718309859155 7.1 7 1 heart inflammation 0.000160493969798435 0.00234840441102122 1.72842448894992 0.615384615384615 7.1 7 1 excessive scratching 0.00777874419359811 0.0497419696184455 1.72842448894992 0.615384615384615 7.1 7 1 increased pituitary adenoma incidence 0.00777874419359811 0.0497419696184455 1.72842448894992 0.615384615384615 7.1 7 1 lymphoid hypoplasia 0.00777874419359811 0.0497419696184455 1.72842448894992 0.615384615384615 7.1 7 1 tracheoesophageal fistula 0.00777874419359811 0.0497419696184455 1.72842448894992 0.615384615384615 7.1 7 1 vestibular hair cell degeneration 0.00777874419359811 0.0497419696184455 1.72842448894992 0.615384615384615 7.1 7 1 increased prostaglandin level 0.00777874419359811 0.0497419696184455 1.72842448894992 0.615384615384615 7.1 7 1 decreased cardiac stroke volume 0.00777874419359811 0.0497419696184455 1.72842448894992 0.615384615384615 7.1 7 1 lethality throughout fetal growth and development, incomplete penetrance 3.78527463502643e-23 1.56931177577137e-20 1.72601048826703 0.614525139664804 7.1 7 1 abnormal astrocyte morphology 1.00535256615383e-06 2.7331306101723e-05 1.72351419210631 0.613636363636364 7.1 7 1 decreased thymus weight 4.21268050773178e-05 0.000779110986095375 1.72145503536544 0.612903225806452 7.1 7 1 abnormal heart shape 0.0019180275911634 0.0169488228526429 1.71642154110999 0.611111111111111 7.1 7 1 abnormal phrenic nerve morphology 0.0019180275911634 0.0169488228526429 1.71642154110999 0.611111111111111 7.1 7 1 abnormal glycogen homeostasis 0.0019180275911634 0.0169488228526429 1.71642154110999 0.611111111111111 7.1 7 1 primary atelectasis 0.0019180275911634 0.0169488228526429 1.71642154110999 0.611111111111111 7.1 7 1 increased effector memory CD8-positive, alpha-beta T cell number 0.0019180275911634 0.0169488228526429 1.71642154110999 0.611111111111111 7.1 7 1 embryonic lethality between implantation and placentation, complete penetrance 8.03478527567788e-07 2.25836478793771e-05 1.70963726624394 0.608695652173913 7.1 7 1 abnormal cranial nerve morphology 0.000488339368289857 0.00577075619297397 1.70963726624394 0.608695652173913 7.1 7 1 bidirectional circling 0.000488339368289857 0.00577075619297397 1.70963726624394 0.608695652173913 7.1 7 1 double outlet right ventricle 6.08677351589475e-14 6.44291451948433e-12 1.70621342659192 0.607476635514019 7.1 7 1 abnormal jaw morphology 0.000126827406123326 0.00191201922867742 1.7052759466872 0.607142857142857 7.1 7 1 hypoxia 0.000126827406123326 0.00191201922867742 1.7052759466872 0.607142857142857 7.1 7 1 abnormal mitotic spindle morphology 0.000126827406123326 0.00191201922867742 1.7052759466872 0.607142857142857 7.1 7 1 decreased brown adipose tissue amount 3.3385852020324e-05 0.000624415841357564 1.70223623911734 0.606060606060606 7.1 7 1 abnormal frontal bone morphology 8.87434879671454e-06 0.000187075785015487 1.69999645459219 0.605263157894737 7.1 7 1 abnormal vasculogenesis 2.37622806675622e-06 6.00088052391481e-05 1.69827755018916 0.604651162790698 7.1 7 1 abnormal blood circulation 2.37622806675622e-06 6.00088052391481e-05 1.69827755018916 0.604651162790698 7.1 7 1 ventricular septal defect 6.30238807282306e-17 9.7982439569671e-15 1.69347472906306 0.602941176470588 7.1 7 1 abnormal pericardium morphology 0.00149023397304286 0.0140681480377386 1.68521387672617 0.6 7.1 7 1 abnormal dopamine level 0.00149023397304286 0.0140681480377386 1.68521387672617 0.6 7.1 7 1 spleen atrophy 0.00149023397304286 0.0140681480377386 1.68521387672617 0.6 7.1 7 1 decreased muscle cell glucose uptake 0.00149023397304286 0.0140681480377386 1.68521387672617 0.6 7.1 7 1 decreased incidence of induced tumors 0.0250652418843592 0.116759904845212 1.68521387672617 0.6 7.1 7 1 primary sex reversal 0.0250652418843592 0.116759904845212 1.68521387672617 0.6 7.1 7 1 abnormal glial cell physiology 0.0250652418843592 0.116759904845212 1.68521387672617 0.6 7.1 7 1 increased left ventricle diastolic pressure 0.0250652418843592 0.116759904845212 1.68521387672617 0.6 7.1 7 1 abnormal spinal cord dorsal column morphology 0.0250652418843592 0.116759904845212 1.68521387672617 0.6 7.1 7 1 ventricular premature beat 0.0250652418843592 0.116759904845212 1.68521387672617 0.6 7.1 7 1 abnormal cerebellar granule cell migration 0.0250652418843592 0.116759904845212 1.68521387672617 0.6 7.1 7 1 abnormal heart and great artery attachment 0.0250652418843592 0.116759904845212 1.68521387672617 0.6 7.1 7 1 increased fatty acid oxidation 0.0250652418843592 0.116759904845212 1.68521387672617 0.6 7.1 7 1 thin ventricular wall 1.57679106861281e-11 1.12064793804982e-09 1.68521387672617 0.6 7.1 7 1 abnormal lung development 5.73601787182919e-11 3.78464888810393e-09 1.68521387672617 0.6 7.1 7 1 abnormal myocardial trabeculae morphology 1.88376131946189e-06 4.88110029391818e-05 1.68521387672617 0.6 7.1 7 1 abnormal artery morphology 2.63488583780696e-05 0.000506121893555584 1.68521387672617 0.6 7.1 7 1 abnormal fontanelle morphology 0.00596850198780371 0.0397500634395227 1.68521387672617 0.6 7.1 7 1 abnormal placenta size 0.00596850198780371 0.0397500634395227 1.68521387672617 0.6 7.1 7 1 ruffled hair 0.000382233548639783 0.00477791935799728 1.68521387672617 0.6 7.1 7 1 abnormal keratinocyte physiology 0.000382233548639783 0.00477791935799728 1.68521387672617 0.6 7.1 7 1 diaphragmatic hernia 0.000382233548639783 0.00477791935799728 1.68521387672617 0.6 7.1 7 1 abnormal neuromuscular synapse morphology 2.2140065765028e-09 1.11259421394964e-07 1.67741196063022 0.597222222222222 7.1 7 1 increased cellular sensitivity to gamma-irradiation 1.48902498503111e-06 3.8784813091779e-05 1.67326200526003 0.595744680851064 7.1 7 1 abnormal muscle morphology 5.53812972763724e-06 0.000125809111392673 1.67183916341882 0.595238095238095 7.1 7 1 failure of primitive streak formation 7.81667541050112e-05 0.00125851003777486 1.66765956551027 0.59375 7.1 7 1 bradykinesia 7.81667541050112e-05 0.00125851003777486 1.66765956551027 0.59375 7.1 7 1 increased oxygen consumption 1.04963488961272e-10 6.44683157509047e-09 1.66561836653168 0.593023255813954 7.1 7 1 abnormal maxilla morphology 3.17784108409966e-07 9.88109962087239e-06 1.66440876713696 0.592592592592593 7.1 7 1 abnormal cell adhesion 3.17784108409966e-07 9.88109962087239e-06 1.66440876713696 0.592592592592593 7.1 7 1 abnormal atrioventricular cushion morphology 0.000297977051963349 0.00396389453821132 1.66440876713696 0.592592592592593 7.1 7 1 decreased circulating fructosamine level 0.000297977051963349 0.00396389453821132 1.66440876713696 0.592592592592593 7.1 7 1 abnormal facial nerve morphology 0.00115296258700163 0.0117540755539613 1.65968033313941 0.590909090909091 7.1 7 1 increased adenoma incidence 0.00115296258700163 0.0117540755539613 1.65968033313941 0.590909090909091 7.1 7 1 abnormal heart development 5.15959704275642e-18 9.8726904952743e-16 1.6532161448896 0.588607594936709 7.1 7 1 abnormal cranial suture morphology 0.00456178926567219 0.0336618350542409 1.6521704673786 0.588235294117647 7.1 7 1 abnormal ductus venosus valve morphology 0.00456178926567219 0.0336618350542409 1.6521704673786 0.588235294117647 7.1 7 1 abnormal parietal bone morphology 0.000231577627468475 0.00315643478535798 1.64647332783591 0.586206896551724 7.1 7 1 hydrops fetalis 9.10165825892015e-09 4.11643180346616e-07 1.63840238015044 0.583333333333333 7.1 7 1 absent mesoderm 1.54821227681791e-07 5.31196970839249e-06 1.63840238015044 0.583333333333333 7.1 7 1 thymus atrophy 2.67781479249988e-06 6.66106429634346e-05 1.63840238015044 0.583333333333333 7.1 7 1 ocular hypertelorism 0.0008893796174451 0.00939419022672903 1.63840238015044 0.583333333333333 7.1 7 1 abnormal rectum morphology 0.0187278609069684 0.0911559463381162 1.63840238015044 0.583333333333333 7.1 7 1 amyloidosis 0.0187278609069684 0.0911559463381162 1.63840238015044 0.583333333333333 7.1 7 1 mesocardia 0.0187278609069684 0.0911559463381162 1.63840238015044 0.583333333333333 7.1 7 1 abnormal glossopharyngeal nerve morphology 0.0187278609069684 0.0911559463381162 1.63840238015044 0.583333333333333 7.1 7 1 abnormal mating frequency 0.0187278609069684 0.0911559463381162 1.63840238015044 0.583333333333333 7.1 7 1 interstitial pneumonia 0.0187278609069684 0.0911559463381162 1.63840238015044 0.583333333333333 7.1 7 1 abnormal embryonic growth/weight/body size 0.0187278609069684 0.0911559463381162 1.63840238015044 0.583333333333333 7.1 7 1 abnormal tracheal ciliated epithelium morphology 0.0187278609069684 0.0911559463381162 1.63840238015044 0.583333333333333 7.1 7 1 decreased synaptic depression 0.0187278609069684 0.0911559463381162 1.63840238015044 0.583333333333333 7.1 7 1 small intestinal inflammation 0.0187278609069684 0.0911559463381162 1.63840238015044 0.583333333333333 7.1 7 1 abnormal nucleotide metabolism 0.0187278609069684 0.0911559463381162 1.63840238015044 0.583333333333333 7.1 7 1 abnormal thymus corticomedullary boundary morphology 0.0187278609069684 0.0911559463381162 1.63840238015044 0.583333333333333 7.1 7 1 abnormal behavioral response to addictive substance 0.0187278609069684 0.0911559463381162 1.63840238015044 0.583333333333333 7.1 7 1 decreased prostaglandin level 0.0187278609069684 0.0911559463381162 1.63840238015044 0.583333333333333 7.1 7 1 decreased red blood cell distribution width 0.0187278609069684 0.0911559463381162 1.63840238015044 0.583333333333333 7.1 7 1 persistent right dorsal aorta 0.0187278609069684 0.0911559463381162 1.63840238015044 0.583333333333333 7.1 7 1 abnormal placenta morphology 1.96592451594521e-09 1.00829633678633e-07 1.63543962720261 0.582278481012658 7.1 7 1 delayed endochondral bone ossification 9.92965981219422e-06 0.000208439061458507 1.6329591828742 0.581395348837209 7.1 7 1 pale kidney 0.000179544061506118 0.00257082900369516 1.63085213876726 0.580645161290323 7.1 7 1 perimembraneous ventricular septal defect 2.60617370737571e-08 1.04562211243501e-06 1.62822596785137 0.579710144927536 7.1 7 1 abnormal triglyceride level 0.00347891599264796 0.0275160684633125 1.62608356526209 0.578947368421053 7.1 7 1 abnormal neural crest cell migration 0.00347891599264796 0.0275160684633125 1.62608356526209 0.578947368421053 7.1 7 1 increased susceptibility to ischemic brain injury 0.00347891599264796 0.0275160684633125 1.62608356526209 0.578947368421053 7.1 7 1 abnormal photoreceptor inner segment morphology 0.00347891599264796 0.0275160684633125 1.62608356526209 0.578947368421053 7.1 7 1 abnormal blastocyst morphology 0.00347891599264796 0.0275160684633125 1.62608356526209 0.578947368421053 7.1 7 1 increased liver cholesterol level 0.00347891599264796 0.0275160684633125 1.62608356526209 0.578947368421053 7.1 7 1 pale yolk sac 1.21327307266379e-09 6.42131227287485e-08 1.62430253178426 0.578313253012048 7.1 7 1 decreased caudal vertebrae number 9.51100044802143e-08 3.42878458180483e-06 1.62377378747053 0.578125 7.1 7 1 abnormal heart ventricle morphology 4.40231671908832e-09 2.08585958832994e-07 1.62039795839055 0.576923076923077 7.1 7 1 abnormal locomotor coordination 0.000138940835505658 0.00204506111432144 1.61712442716148 0.575757575757576 7.1 7 1 impaired limb coordination 1.27441254237616e-06 3.35460444355631e-05 1.61239599316393 0.574074074074074 7.1 7 1 abnormal vitelline vasculature morphology 1.66252142988589e-12 1.40187188367497e-10 1.61194370817286 0.573913043478261 7.1 7 1 lethality throughout fetal growth and development, complete penetrance 1.1480034185725e-19 2.7196747654277e-17 1.61130098739608 0.573684210526316 7.1 7 1 lymphoid hyperplasia 0.000526176579750044 0.00599718822286144 1.60496559688207 0.571428571428571 7.1 7 1 premature aging 0.000526176579750044 0.00599718822286144 1.60496559688207 0.571428571428571 7.1 7 1 abnormal hormone level 0.000526176579750044 0.00599718822286144 1.60496559688207 0.571428571428571 7.1 7 1 abnormal blood flow velocity 0.0140049087800004 0.0795370104800254 1.60496559688207 0.571428571428571 7.1 7 1 absent visceral yolk sac blood islands 0.0140049087800004 0.0795370104800254 1.60496559688207 0.571428571428571 7.1 7 1 intestinal obstruction 0.0140049087800004 0.0795370104800254 1.60496559688207 0.571428571428571 7.1 7 1 abnormal voluntary movement 0.0140049087800004 0.0795370104800254 1.60496559688207 0.571428571428571 7.1 7 1 abnormal vascular endothelial cell migration 0.0140049087800004 0.0795370104800254 1.60496559688207 0.571428571428571 7.1 7 1 split sternum 0.0140049087800004 0.0795370104800254 1.60496559688207 0.571428571428571 7.1 7 1 decreased CNS synapse formation 0.0140049087800004 0.0795370104800254 1.60496559688207 0.571428571428571 7.1 7 1 decreased tongue size 0.0140049087800004 0.0795370104800254 1.60496559688207 0.571428571428571 7.1 7 1 sternebra fusion 0.0140049087800004 0.0795370104800254 1.60496559688207 0.571428571428571 7.1 7 1 absent kidney 4.6828535939976e-06 0.000109376510000648 1.60496559688207 0.571428571428571 7.1 7 1 left pulmonary isomerism 0.00264980316490531 0.0220079645165341 1.60496559688207 0.571428571428571 7.1 7 1 abnormal erythrocyte physiology 0.00264980316490531 0.0220079645165341 1.60496559688207 0.571428571428571 7.1 7 1 decreased vocalization 0.00264980316490531 0.0220079645165341 1.60496559688207 0.571428571428571 7.1 7 1 increased heart weight 2.33034193695066e-14 2.63487525825671e-12 1.59630571056796 0.568345323741007 7.1 7 1 increased erythroid progenitor cell number 8.28587858367287e-05 0.00130450145423331 1.59412123474097 0.567567567567568 7.1 7 1 abnormal cellular respiration 0.000403963160295708 0.00499929532953021 1.59159088357472 0.566666666666667 7.1 7 1 atrioventricular septal defect 2.82066628891859e-06 6.98149989421393e-05 1.58982441200582 0.566037735849057 7.1 7 1 abnormal cell cycle 6.27353934236485e-12 4.7289179133735e-10 1.58752031865509 0.565217391304348 7.1 7 1 abnormal cochlear ganglion morphology 0.00201697277132696 0.017666266791112 1.58752031865509 0.565217391304348 7.1 7 1 abnormal rostral-caudal axis patterning 2.18624344415143e-06 5.60647481167699e-05 1.58307970237913 0.563636363636364 7.1 7 1 decreased circulating total protein level 2.18624344415143e-06 5.60647481167699e-05 1.58307970237913 0.563636363636364 7.1 7 1 abnormal embryonic hematopoiesis 0.000309886313878969 0.00406405785310724 1.57988800943078 0.5625 7.1 7 1 increased fatty acid level 0.000309886313878969 0.00406405785310724 1.57988800943078 0.5625 7.1 7 1 increased fibroblast apoptosis 0.000309886313878969 0.00406405785310724 1.57988800943078 0.5625 7.1 7 1 vasculature congestion 0.0104879079636988 0.0630923121153585 1.57988800943078 0.5625 7.1 7 1 abnormal olfaction 0.0104879079636988 0.0630923121153585 1.57988800943078 0.5625 7.1 7 1 increased intestinal adenocarcinoma incidence 0.0104879079636988 0.0630923121153585 1.57988800943078 0.5625 7.1 7 1 increased pancreatic beta cell number 0.0104879079636988 0.0630923121153585 1.57988800943078 0.5625 7.1 7 1 dystonia 0.0104879079636988 0.0630923121153585 1.57988800943078 0.5625 7.1 7 1 impaired somite development 0.0104879079636988 0.0630923121153585 1.57988800943078 0.5625 7.1 7 1 abnormal pulmonary alveolus wall morphology 0.0104879079636988 0.0630923121153585 1.57988800943078 0.5625 7.1 7 1 embryonic lethality between somite formation and embryo turning, incomplete penetrance 0.0104879079636988 0.0630923121153585 1.57988800943078 0.5625 7.1 7 1 perinatal lethality, incomplete penetrance 1.37693413823852e-21 4.28140458608539e-19 1.57833453056212 0.561946902654867 7.1 7 1 abnormal mammary gland development 4.92225579578359e-05 0.000868376687376715 1.57560647010983 0.560975609756098 7.1 7 1 abnormal cell differentiation 4.92225579578359e-05 0.000868376687376715 1.57560647010983 0.560975609756098 7.1 7 1 small spleen 1.70094259659002e-09 8.8147806437868e-08 1.5741008738651 0.56043956043956 7.1 7 1 pallor 7.30483747587986e-17 1.10125958916674e-14 1.57286628494443 0.56 7.1 7 1 increased B cell derived lymphoma incidence 7.97809618940804e-06 0.00016961978009532 1.57286628494443 0.56 7.1 7 1 increased insulin sensitivity 5.23056560642283e-14 5.65697041129426e-12 1.57129498995447 0.559440559440559 7.1 7 1 pericardial edema 2.17345901066486e-07 7.11378853819583e-06 1.56956194400967 0.558823529411765 7.1 7 1 distended pericardium 6.15984012008523e-06 0.000137422442140915 1.56638469311086 0.557692307692308 7.1 7 1 abnormal placenta vasculature 6.15984012008523e-06 0.000137422442140915 1.56638469311086 0.557692307692308 7.1 7 1 decreased cell proliferation 2.0891776737089e-17 3.46455297556726e-15 1.56375702074591 0.556756756756757 7.1 7 1 abnormal digit morphology 1.30351913389117e-07 4.56690682472433e-06 1.5603832191909 0.555555555555556 7.1 7 1 albuminuria 2.9166612522725e-05 0.000555953629504049 1.5603832191909 0.555555555555556 7.1 7 1 abnormal epidermis stratum granulosum morphology 0.000182068596343077 0.0025806018997345 1.5603832191909 0.555555555555556 7.1 7 1 abnormal heart valve morphology 0.00116789151365764 0.0118094721147292 1.5603832191909 0.555555555555556 7.1 7 1 abnormal trigeminal nerve morphology 0.00116789151365764 0.0118094721147292 1.5603832191909 0.555555555555556 7.1 7 1 increased brain weight 0.00116789151365764 0.0118094721147292 1.5603832191909 0.555555555555556 7.1 7 1 abnormal eye muscle morphology 0.00116789151365764 0.0118094721147292 1.5603832191909 0.555555555555556 7.1 7 1 cortical renal glomerulopathies 0.00786649135880818 0.0497910871629398 1.5603832191909 0.555555555555556 7.1 7 1 abnormal thymus medulla morphology 0.00786649135880818 0.0497910871629398 1.5603832191909 0.555555555555556 7.1 7 1 acidosis 0.00786649135880818 0.0497910871629398 1.5603832191909 0.555555555555556 7.1 7 1 abnormal metacarpal bone morphology 0.00786649135880818 0.0497910871629398 1.5603832191909 0.555555555555556 7.1 7 1 abnormal body wall morphology 0.00786649135880818 0.0497910871629398 1.5603832191909 0.555555555555556 7.1 7 1 absent inner cell mass 0.00786649135880818 0.0497910871629398 1.5603832191909 0.555555555555556 7.1 7 1 abnormal hypoglossal nerve topology 0.00786649135880818 0.0497910871629398 1.5603832191909 0.555555555555556 7.1 7 1 increased adipocyte glucose uptake 0.00786649135880818 0.0497910871629398 1.5603832191909 0.555555555555556 7.1 7 1 deformed nails 0.0593458302347467 0.209989690908866 1.5603832191909 0.555555555555556 7.1 7 1 abnormal geniculate ganglion morphology 0.0593458302347467 0.209989690908866 1.5603832191909 0.555555555555556 7.1 7 1 abnormal ion homeostasis 0.0593458302347467 0.209989690908866 1.5603832191909 0.555555555555556 7.1 7 1 increased pheochromocytoma incidence 0.0593458302347467 0.209989690908866 1.5603832191909 0.555555555555556 7.1 7 1 long gestation period 0.0593458302347467 0.209989690908866 1.5603832191909 0.555555555555556 7.1 7 1 abnormal posterior semicircular canal morphology 0.0593458302347467 0.209989690908866 1.5603832191909 0.555555555555556 7.1 7 1 decreased circulating bicarbonate level 0.0593458302347467 0.209989690908866 1.5603832191909 0.555555555555556 7.1 7 1 premature neuronal precursor differentiation 0.0593458302347467 0.209989690908866 1.5603832191909 0.555555555555556 7.1 7 1 decreased vestibular hair cell number 0.0593458302347467 0.209989690908866 1.5603832191909 0.555555555555556 7.1 7 1 abnormal stria vascularis vasculature morphology 0.0593458302347467 0.209989690908866 1.5603832191909 0.555555555555556 7.1 7 1 increased neuronal precursor cell number 0.0593458302347467 0.209989690908866 1.5603832191909 0.555555555555556 7.1 7 1 liver hyperplasia 0.0593458302347467 0.209989690908866 1.5603832191909 0.555555555555556 7.1 7 1 abnormal intervertebral disk development 0.0593458302347467 0.209989690908866 1.5603832191909 0.555555555555556 7.1 7 1 abnormal inguinal fat pad morphology 0.0593458302347467 0.209989690908866 1.5603832191909 0.555555555555556 7.1 7 1 enhanced conditioned place preference behavior 0.0593458302347467 0.209989690908866 1.5603832191909 0.555555555555556 7.1 7 1 abnormal retinal development 0.0593458302347467 0.209989690908866 1.5603832191909 0.555555555555556 7.1 7 1 abnormal liver vasculature morphology 0.0593458302347467 0.209989690908866 1.5603832191909 0.555555555555556 7.1 7 1 abnormal hippocampus granule cell morphology 0.0593458302347467 0.209989690908866 1.5603832191909 0.555555555555556 7.1 7 1 axonal spheroids 0.0593458302347467 0.209989690908866 1.5603832191909 0.555555555555556 7.1 7 1 retropulsion 0.0593458302347467 0.209989690908866 1.5603832191909 0.555555555555556 7.1 7 1 abnormal ventricle myocardium morphology 0.0593458302347467 0.209989690908866 1.5603832191909 0.555555555555556 7.1 7 1 fusion of atlas and occipital bones 0.0593458302347467 0.209989690908866 1.5603832191909 0.555555555555556 7.1 7 1 decreased effector memory CD4-positive, alpha-beta T cell number 0.0593458302347467 0.209989690908866 1.5603832191909 0.555555555555556 7.1 7 1 abnormal oxidative phosphorylation 0.0593458302347467 0.209989690908866 1.5603832191909 0.555555555555556 7.1 7 1 increased core body temperature 0.0593458302347467 0.209989690908866 1.5603832191909 0.555555555555556 7.1 7 1 increased myeloid cell number 0.0593458302347467 0.209989690908866 1.5603832191909 0.555555555555556 7.1 7 1 trigeminal neuroma 0.0593458302347467 0.209989690908866 1.5603832191909 0.555555555555556 7.1 7 1 symmetric azygos veins 0.0593458302347467 0.209989690908866 1.5603832191909 0.555555555555556 7.1 7 1 decreased fatty acid oxidation 0.0593458302347467 0.209989690908866 1.5603832191909 0.555555555555556 7.1 7 1 adipose tissue inflammation 0.0593458302347467 0.209989690908866 1.5603832191909 0.555555555555556 7.1 7 1 abnormal neural tube closure 1.6898700158525e-08 7.12466383802218e-07 1.55662325962658 0.55421686746988 7.1 7 1 persistence of hyaloid vascular system 0.00013948655855694 0.00204703725315863 1.552170675932 0.552631578947368 7.1 7 1 increased embryonic tissue cell apoptosis 6.03487265070266e-08 2.25740537122148e-06 1.54838027135097 0.551282051282051 7.1 7 1 thymus hypoplasia 6.60018782721064e-13 6.19545932837225e-11 1.5468146694588 0.550724637681159 7.1 7 1 abnormal trophoblast layer morphology 1.32639630381828e-05 0.000270443508667867 1.54202576955336 0.549019607843137 7.1 7 1 abnormal dendritic spine morphology 1.32639630381828e-05 0.000270443508667867 1.54202576955336 0.549019607843137 7.1 7 1 abnormal cardiovascular system physiology 2.3288478967996e-12 1.89934726009475e-10 1.54161169174199 0.548872180451128 7.1 7 1 embryonic lethality during organogenesis, incomplete penetrance 3.74566641689443e-20 1.03526057911388e-17 1.53867353961955 0.547826086956522 7.1 7 1 spina bifida 8.18269053144643e-05 0.00129234556806178 1.53809203034531 0.547619047619048 7.1 7 1 delayed bone ossification 1.66112141551702e-07 5.66032811109397e-06 1.53541708768384 0.546666666666667 7.1 7 1 edema 2.50339821160007e-15 3.19343746223342e-13 1.53498163190174 0.546511627906977 7.1 7 1 abnormal heart morphology 6.11650686055385e-20 1.52148108156277e-17 1.53201261520561 0.545454545454545 7.1 7 1 lethality, incomplete penetrance 6.26639203562043e-05 0.00105321960733823 1.53201261520561 0.545454545454545 7.1 7 1 abnormal abdominal fat pad morphology 0.00444601185838972 0.0334122492378986 1.53201261520561 0.545454545454545 7.1 7 1 abnormal germ layer development 0.00444601185838972 0.0334122492378986 1.53201261520561 0.545454545454545 7.1 7 1 increased myocardial infarction size 0.00444601185838972 0.0334122492378986 1.53201261520561 0.545454545454545 7.1 7 1 abnormal limb posture 0.00444601185838972 0.0334122492378986 1.53201261520561 0.545454545454545 7.1 7 1 abnormal mesenteric lymph node morphology 0.00444601185838972 0.0334122492378986 1.53201261520561 0.545454545454545 7.1 7 1 embryonic lethality before implantation, incomplete penetrance 0.00444601185838972 0.0334122492378986 1.53201261520561 0.545454545454545 7.1 7 1 abnormal thrombopoiesis 0.0430616915803638 0.177933484727832 1.53201261520561 0.545454545454545 7.1 7 1 delayed hepatic development 0.0430616915803638 0.177933484727832 1.53201261520561 0.545454545454545 7.1 7 1 variable body spotting 0.0430616915803638 0.177933484727832 1.53201261520561 0.545454545454545 7.1 7 1 patent ductus arteriosus 0.0430616915803638 0.177933484727832 1.53201261520561 0.545454545454545 7.1 7 1 loss of cortex neurons 0.0430616915803638 0.177933484727832 1.53201261520561 0.545454545454545 7.1 7 1 impaired luteinization 0.0430616915803638 0.177933484727832 1.53201261520561 0.545454545454545 7.1 7 1 abnormal lymph circulation 0.0430616915803638 0.177933484727832 1.53201261520561 0.545454545454545 7.1 7 1 abnormal pituitary gland development 0.0430616915803638 0.177933484727832 1.53201261520561 0.545454545454545 7.1 7 1 abnormal coronal suture morphology 0.0430616915803638 0.177933484727832 1.53201261520561 0.545454545454545 7.1 7 1 abnormal dorsal-ventral polarity of the somites 0.0430616915803638 0.177933484727832 1.53201261520561 0.545454545454545 7.1 7 1 increased glycogen level 0.0430616915803638 0.177933484727832 1.53201261520561 0.545454545454545 7.1 7 1 palatal shelf hypoplasia 0.0430616915803638 0.177933484727832 1.53201261520561 0.545454545454545 7.1 7 1 shortened PR interval 0.0430616915803638 0.177933484727832 1.53201261520561 0.545454545454545 7.1 7 1 abnormal pulmonary alveolar sac morphology 0.0430616915803638 0.177933484727832 1.53201261520561 0.545454545454545 7.1 7 1 abnormal phrenic nerve innervation pattern to diaphragm 0.0430616915803638 0.177933484727832 1.53201261520561 0.545454545454545 7.1 7 1 hypolactation 0.0430616915803638 0.177933484727832 1.53201261520561 0.545454545454545 7.1 7 1 decreased mean corpuscular hemoglobin 7.67094569309953e-07 2.19327326569944e-05 1.5282576823252 0.544117647058823 7.1 7 1 abnormal forelimb morphology 4.79871578342831e-05 0.000852628965091279 1.52646184486066 0.543478260869565 7.1 7 1 abnormal allantois morphology 4.79871578342831e-05 0.000852628965091279 1.52646184486066 0.543478260869565 7.1 7 1 abnormal hippocampus pyramidal cell morphology 0.000392215989734857 0.00487818637232728 1.52471731703796 0.542857142857143 7.1 7 1 impaired adaptive thermogenesis 0.000392215989734857 0.00487818637232728 1.52471731703796 0.542857142857143 7.1 7 1 embryonic lethality between implantation and somite formation, complete penetrance 1.01750351054485e-20 2.97769409703565e-18 1.52471731703796 0.542857142857143 7.1 7 1 abnormal digestive system morphology 0.00334958286227825 0.0268344198709087 1.52137363871113 0.541666666666667 7.1 7 1 abnormal body weight 0.00334958286227825 0.0268344198709087 1.52137363871113 0.541666666666667 7.1 7 1 abnormal nursing 0.00334958286227825 0.0268344198709087 1.52137363871113 0.541666666666667 7.1 7 1 blindness 0.00334958286227825 0.0268344198709087 1.52137363871113 0.541666666666667 7.1 7 1 increased hemangiosarcoma incidence 0.00334958286227825 0.0268344198709087 1.52137363871113 0.541666666666667 7.1 7 1 embryonic growth arrest 2.6863877495033e-19 5.81077350164302e-17 1.52086259617209 0.541484716157205 7.1 7 1 embryonic lethality during organogenesis, complete penetrance 4.48135534239758e-45 1.1147371414214e-41 1.51970179954771 0.541071428571429 7.1 7 1 kidney cysts 3.49906508206288e-07 1.07455856686808e-05 1.51821069975331 0.540540540540541 7.1 7 1 abnormal vocalization 0.00029878602046819 0.00396389453821132 1.51821069975331 0.540540540540541 7.1 7 1 increased circulating phosphate level 0.00029878602046819 0.00396389453821132 1.51821069975331 0.540540540540541 7.1 7 1 decreased width of hypertrophic chondrocyte zone 0.00029878602046819 0.00396389453821132 1.51821069975331 0.540540540540541 7.1 7 1 prenatal lethality, complete penetrance 7.93068669531539e-23 3.03501279301493e-20 1.51548010496958 0.539568345323741 7.1 7 1 small liver 2.07214734440909e-07 6.82710797247364e-06 1.51237142783118 0.538461538461538 7.1 7 1 failure of heart looping 0.000227684870682237 0.00311190173528607 1.51237142783118 0.538461538461538 7.1 7 1 liver hypoplasia 2.15521064426301e-05 0.000420477370792489 1.51237142783118 0.538461538461538 7.1 7 1 abnormal nasal bone morphology 0.00252677622414566 0.021270239788705 1.51237142783118 0.538461538461538 7.1 7 1 decreased circulating glycerol level 0.00252677622414566 0.021270239788705 1.51237142783118 0.538461538461538 7.1 7 1 increased thymocyte apoptosis 0.00252677622414566 0.021270239788705 1.51237142783118 0.538461538461538 7.1 7 1 absent common myeloid progenitor cells 0.0315018304059005 0.142474187517595 1.51237142783118 0.538461538461538 7.1 7 1 increased foot pad pigmentation 0.0315018304059005 0.142474187517595 1.51237142783118 0.538461538461538 7.1 7 1 abnormal grip strength 0.0315018304059005 0.142474187517595 1.51237142783118 0.538461538461538 7.1 7 1 abnormal otolith morphology 0.0315018304059005 0.142474187517595 1.51237142783118 0.538461538461538 7.1 7 1 anal atresia 0.0315018304059005 0.142474187517595 1.51237142783118 0.538461538461538 7.1 7 1 hypoglycemia 1.59592026456047e-08 6.90408984016377e-07 1.51004827663635 0.537634408602151 7.1 7 1 abnormal embryonic tissue morphology 1.30652778423198e-12 1.16070995117038e-10 1.50943193040099 0.537414965986395 7.1 7 1 perinatal lethality, complete penetrance 2.34678891743261e-17 3.76621769813781e-15 1.5032424252487 0.535211267605634 7.1 7 1 decreased liver weight 9.49402879491286e-07 2.59520842058744e-05 1.5032424252487 0.535211267605634 7.1 7 1 decreased oxygen consumption 0.000132343146916616 0.00197719866639689 1.50232244824426 0.534883720930233 7.1 7 1 abnormal fertility/fecundity 7.29128448694269e-07 2.09677111690982e-05 1.50053290393426 0.534246575342466 7.1 7 1 decreased embryo size 9.84262850094463e-37 6.99529668459993e-34 1.49835961842808 0.53347280334728 7.1 7 1 kyphosis 1.60626689193835e-12 1.37778927368849e-10 1.49796789042326 0.533333333333333 7.1 7 1 abnormal erythropoiesis 3.33011938013356e-09 1.60892232810359e-07 1.49796789042326 0.533333333333333 7.1 7 1 increased metastatic potential 0.00144281332888002 0.0138774611911298 1.49796789042326 0.533333333333333 7.1 7 1 abnormal microglial cell physiology 0.00144281332888002 0.0138774611911298 1.49796789042326 0.533333333333333 7.1 7 1 abnormal optic cup morphology 0.00144281332888002 0.0138774611911298 1.49796789042326 0.533333333333333 7.1 7 1 decreased hepatocyte number 0.0231893736853682 0.110399171372925 1.49796789042326 0.533333333333333 7.1 7 1 absent egg cylinders 0.0231893736853682 0.110399171372925 1.49796789042326 0.533333333333333 7.1 7 1 dilated ureter 0.0231893736853682 0.110399171372925 1.49796789042326 0.533333333333333 7.1 7 1 abnormal trophectoderm morphology 0.0231893736853682 0.110399171372925 1.49796789042326 0.533333333333333 7.1 7 1 abnormal olfactory nerve morphology 0.0231893736853682 0.110399171372925 1.49796789042326 0.533333333333333 7.1 7 1 ostium primum atrial septal defect 0.0231893736853682 0.110399171372925 1.49796789042326 0.533333333333333 7.1 7 1 abnormal visceral yolk sac morphology 3.30261818336206e-07 1.02052953181529e-05 1.49322748570673 0.531645569620253 7.1 7 1 decreased circulating LDL cholesterol level 4.3550638080938e-06 0.000102684561351975 1.4921164533513 0.53125 7.1 7 1 abnormal lymphatic vessel morphology 0.00109193591833724 0.0112239280862143 1.4921164533513 0.53125 7.1 7 1 decreased heart weight 2.53638453595319e-07 8.0887904271584e-06 1.49103285389353 0.530864197530864 7.1 7 1 abnormal long bone hypertrophic chondrocyte zone 5.87852045499032e-05 0.00100847031943368 1.49032519710478 0.530612244897959 7.1 7 1 insulin resistance 5.43484285100312e-11 3.65383015996493e-09 1.48945670922768 0.53030303030303 7.1 7 1 abnormal gluconeogenesis 4.48793100583225e-05 0.000817855558755145 1.48695342064074 0.529411764705882 7.1 7 1 failure of chorioallantoic fusion 4.48793100583225e-05 0.000817855558755145 1.48695342064074 0.529411764705882 7.1 7 1 enlarged liver sinusoidal spaces 0.000827142030840014 0.00875538639027462 1.48695342064074 0.529411764705882 7.1 7 1 abnormal adipose tissue morphology 0.0171547914989788 0.0911559463381162 1.48695342064074 0.529411764705882 7.1 7 1 hyperlipidemia 0.0171547914989788 0.0911559463381162 1.48695342064074 0.529411764705882 7.1 7 1 abnormal heart rate 0.0171547914989788 0.0911559463381162 1.48695342064074 0.529411764705882 7.1 7 1 abnormal tendon morphology 0.0171547914989788 0.0911559463381162 1.48695342064074 0.529411764705882 7.1 7 1 delayed heart development 0.0171547914989788 0.0911559463381162 1.48695342064074 0.529411764705882 7.1 7 1 abnormal cell cytoskeleton morphology 0.0171547914989788 0.0911559463381162 1.48695342064074 0.529411764705882 7.1 7 1 increased circulating bilirubin level 3.42724294723681e-05 0.000638596766385885 1.4838361178721 0.528301886792453 7.1 7 1 heart right ventricle hypertrophy 0.000627086605878617 0.00681169402673826 1.48236405823135 0.527777777777778 7.1 7 1 abnormal pharyngeal arch morphology 0.000627086605878617 0.00681169402673826 1.48236405823135 0.527777777777778 7.1 7 1 abnormal glucose homeostasis 2.48964414011669e-14 2.75243991046234e-12 1.48150670481422 0.527472527472527 7.1 7 1 increased grip strength 6.77800317746836e-08 2.51646013491829e-06 1.48150670481422 0.527472527472527 7.1 7 1 embryonic lethality, complete penetrance 7.3677319450206e-24 3.33222422058886e-21 1.47918459399162 0.526645768025078 7.1 7 1 incomplete somite formation 0.000475785422591804 0.00564924218948502 1.4782577866019 0.526315789473684 7.1 7 1 decreased neuron apoptosis 0.000475785422591804 0.00564924218948502 1.4782577866019 0.526315789473684 7.1 7 1 impaired branching involved in ureteric bud morphogenesis 0.000475785422591804 0.00564924218948502 1.4782577866019 0.526315789473684 7.1 7 1 kyphoscoliosis 0.0127415750989862 0.0746827850846695 1.4782577866019 0.526315789473684 7.1 7 1 irregular coat pigmentation 0.0127415750989862 0.0746827850846695 1.4782577866019 0.526315789473684 7.1 7 1 abnormal stationary movement 0.0127415750989862 0.0746827850846695 1.4782577866019 0.526315789473684 7.1 7 1 abnormal long term depression 0.0127415750989862 0.0746827850846695 1.4782577866019 0.526315789473684 7.1 7 1 increased malignant tumor incidence 0.0127415750989862 0.0746827850846695 1.4782577866019 0.526315789473684 7.1 7 1 increased liver adenoma incidence 0.0127415750989862 0.0746827850846695 1.4782577866019 0.526315789473684 7.1 7 1 Leydig cell hypoplasia 0.0127415750989862 0.0746827850846695 1.4782577866019 0.526315789473684 7.1 7 1 decreased circulating magnesium level 0.0127415750989862 0.0746827850846695 1.4782577866019 0.526315789473684 7.1 7 1 increased urine protein level 6.76947601745231e-07 1.96948205770908e-05 1.47636258431139 0.525641025641026 7.1 7 1 decreased circulating serum albumin level 2.35927423373615e-08 9.54259293726612e-07 1.47527140723503 0.525252525252525 7.1 7 1 hemorrhage 1.37717409625283e-17 2.53757078846586e-15 1.4700801903356 0.523404255319149 7.1 7 1 increased circulating creatinine level 2.34125792462211e-07 7.51468269354516e-06 1.46966326458678 0.523255813953488 7.1 7 1 prenatal lethality, incomplete penetrance 2.95158956563015e-22 1.04886843492929e-19 1.46901867543564 0.523026315789474 7.1 7 1 muscular atrophy 0.000208658490292303 0.00288354441445613 1.46817875623871 0.522727272727273 7.1 7 1 abnormal embryo size 3.7249253260624e-09 1.78187533626543e-07 1.46648405201835 0.52212389380531 7.1 7 1 abnormal blood vessel physiology 0.00709587268063998 0.0459063284605772 1.46540337106624 0.521739130434783 7.1 7 1 abnormal pulmonary artery morphology 0.00709587268063998 0.0459063284605772 1.46540337106624 0.521739130434783 7.1 7 1 blistering 0.00709587268063998 0.0459063284605772 1.46540337106624 0.521739130434783 7.1 7 1 abnormal circulating insulin level 0.00709587268063998 0.0459063284605772 1.46540337106624 0.521739130434783 7.1 7 1 abnormal basicranium morphology 0.00709587268063998 0.0459063284605772 1.46540337106624 0.521739130434783 7.1 7 1 vertebral transformation 0.00012079826923185 0.00183918022411175 1.46285926799147 0.520833333333333 7.1 7 1 decreased respiratory quotient 9.19822549616466e-05 0.00143451949352411 1.46051869316268 0.52 7.1 7 1 abnormal egg cylinder morphology 0.00531555619173712 0.036934206779179 1.46051869316268 0.52 7.1 7 1 abnormal cochlear outer hair cell morphology 0.00531555619173712 0.036934206779179 1.46051869316268 0.52 7.1 7 1 abnormal preimplantation embryo development 0.00531555619173712 0.036934206779179 1.46051869316268 0.52 7.1 7 1 abnormal snout morphology 7.00726899632703e-05 0.00115434315419626 1.45835816255149 0.519230769230769 7.1 7 1 kinked neural tube 7.00726899632703e-05 0.00115434315419626 1.45835816255149 0.519230769230769 7.1 7 1 abnormal somite development 1.0510033154234e-06 2.79778078151962e-05 1.45767445033276 0.518987341772152 7.1 7 1 extramedullary hematopoiesis 1.65570739543309e-08 7.04029426690567e-07 1.45733904433867 0.518867924528302 7.1 7 1 axon degeneration 5.3405014639891e-05 0.000925748947154904 1.45635767124484 0.518518518518518 7.1 7 1 preweaning lethality, incomplete penetrance 1.66780868901617e-28 9.21927580872827e-26 1.45584898885879 0.518337408312958 7.1 7 1 decreased body length 1.45961672344077e-19 3.30072418141719e-17 1.45559836067589 0.518248175182482 7.1 7 1 abnormal embryonic neuroepithelium morphology 3.10575996018495e-05 0.000585292467955189 1.45277058338463 0.517241379310345 7.1 7 1 decreased trophoblast giant cell number 0.00300073030384561 0.0245670978006144 1.45277058338463 0.517241379310345 7.1 7 1 abnormal embryonic erythropoiesis 0.00300073030384561 0.0245670978006144 1.45277058338463 0.517241379310345 7.1 7 1 abnormal eating behavior 2.36973475037656e-05 0.000458732699732428 1.45115639384754 0.516666666666667 7.1 7 1 muscular ventricular septal defect 2.36973475037656e-05 0.000458732699732428 1.45115639384754 0.516666666666667 7.1 7 1 abnormal object recognition memory 0.00226024400931868 0.0193874378385525 1.4496463455709 0.516129032258065 7.1 7 1 abnormal postnatal growth/weight/body size 0.00226024400931868 0.0193874378385525 1.4496463455709 0.516129032258065 7.1 7 1 abnormal capillary morphology 0.00226024400931868 0.0193874378385525 1.4496463455709 0.516129032258065 7.1 7 1 decreased erythrocyte cell number 1.13323517578795e-11 8.17078985441309e-10 1.44906925705753 0.515923566878981 7.1 7 1 abnormal tooth development 0.00170490813814817 0.0155917610060426 1.44690080324974 0.515151515151515 7.1 7 1 abnormal aorta morphology 0.00170490813814817 0.0155917610060426 1.44690080324974 0.515151515151515 7.1 7 1 increased osteoblast cell number 0.00170490813814817 0.0155917610060426 1.44690080324974 0.515151515151515 7.1 7 1 abnormal craniofacial morphology 4.31479950765179e-08 1.63863569088303e-06 1.44524814670691 0.514563106796116 7.1 7 1 increased bone mineral content 1.94676995296621e-08 8.07098376333907e-07 1.44299659169213 0.513761467889908 7.1 7 1 abnormal breathing pattern 0.000973626112700733 0.0100897735614084 1.44230016476564 0.513513513513513 7.1 7 1 abnormal humerus morphology 0.000973626112700733 0.0100897735614084 1.44230016476564 0.513513513513513 7.1 7 1 abnormal nervous system physiology 8.78983575379601e-09 4.01187457570047e-07 1.44097998154846 0.51304347826087 7.1 7 1 abnormal skeleton morphology 8.78983575379601e-09 4.01187457570047e-07 1.44097998154846 0.51304347826087 7.1 7 1 increased circulating alkaline phosphatase level 1.02010164004842e-11 7.4632436165307e-10 1.4390200799205 0.512345679012346 7.1 7 1 abnormal developmental patterning 1.23212590661459e-06 3.26054594968488e-05 1.43859721183941 0.51219512195122 7.1 7 1 increased bone trabecula number 0.0005583208989369 0.00628426803667664 1.43859721183941 0.51219512195122 7.1 7 1 lethality at weaning, incomplete penetrance 0.0005583208989369 0.00628426803667664 1.43859721183941 0.51219512195122 7.1 7 1 kidney failure 0.000423354981346743 0.00521334413910903 1.43700408092929 0.511627906976744 7.1 7 1 cleft palate 1.0576628100299e-09 5.75628505728342e-08 1.43650546743834 0.511450381679389 7.1 7 1 pulmonary hypoplasia 0.000243970959762312 0.00329824870874321 1.43422457593717 0.51063829787234 7.1 7 1 decreased hemoglobin content 2.82043657164139e-10 1.67043713618046e-08 1.43422457593717 0.51063829787234 7.1 7 1 polydactyly 1.4568802458769e-07 5.0333189050261e-06 1.43300499721613 0.510204081632653 7.1 7 1 increased T cell derived lymphoma incidence 0.000185395211608878 0.00260162924508433 1.43300499721613 0.510204081632653 7.1 7 1 decreased heart rate 1.11634389675767e-07 3.96700777597817e-06 1.43243179521724 0.51 7.1 7 1 microphthalmia 5.78157418082208e-11 3.78464888810393e-09 1.43188107172812 0.509803921568627 7.1 7 1 abnormal axon morphology 3.8529982932844e-08 1.47451280839153e-06 1.43035128425832 0.509259259259259 7.1 7 1 decreased birth body size 1.73687931285956e-08 7.26132317771117e-07 1.42898252704851 0.508771929824561 7.1 7 1 absent vitelline blood vessels 6.21743428637572e-05 0.00105209984948025 1.42898252704851 0.508771929824561 7.1 7 1 decreased brain weight 6.21743428637572e-05 0.00105209984948025 1.42898252704851 0.508771929824561 7.1 7 1 decreased circulating HDL cholesterol level 2.71423246625152e-09 1.35033065196013e-07 1.42628778629168 0.5078125 7.1 7 1 abnormal bone structure 2.95507522028983e-13 2.82721138864267e-11 1.42617409256619 0.507772020725389 7.1 7 1 abnormal lipid homeostasis 2.08262499771144e-09 1.05725095547086e-07 1.42595020338368 0.507692307692308 7.1 7 1 internal hemorrhage 1.60292002665896e-05 0.000321553513412433 1.42530526887288 0.507462686567164 7.1 7 1 decreased spleen weight 1.22360767466191e-05 0.000251547445514173 1.42469772186995 0.507246376811594 7.1 7 1 decreased bone marrow cell number 7.13676363190048e-06 0.00015370302627145 1.4235824986043 0.506849315068493 7.1 7 1 abnormal placenta labyrinth morphology 3.18550802197109e-06 7.73068410210058e-05 1.42212141495879 0.506329113924051 7.1 7 1 abnormal nervous system morphology 3.18550802197109e-06 7.73068410210058e-05 1.42212141495879 0.506329113924051 7.1 7 1 anophthalmia 8.3423175190154e-07 2.32652185799694e-05 1.42012405342093 0.50561797752809 7.1 7 1 limb grasping 2.16017991984161e-12 1.79114918353533e-10 1.41977725878029 0.505494505494505 7.1 7 1 abnormal bone mineralization 1.17649819094935e-08 5.17971548670177e-07 1.41595105344761 0.504132231404959 7.1 7 1 embryonic lethality before implantation, complete penetrance 6.91992911983221e-09 3.21744367954815e-07 1.41557965644998 0.504 7.1 7 1 abnormal endoderm development 0.00258267424545633 0.0215583965958813 1.40434489727181 0.5 7.1 7 1 increased width of hypertrophic chondrocyte zone 0.00258267424545633 0.0215583965958813 1.40434489727181 0.5 7.1 7 1 straub tail 0.00607204923348372 0.0402242941898555 1.40434489727181 0.5 7.1 7 1 increased bone resorption 0.00607204923348372 0.0402242941898555 1.40434489727181 0.5 7.1 7 1 abnormal brainstem morphology 0.00607204923348372 0.0402242941898555 1.40434489727181 0.5 7.1 7 1 increased triglyceride level 0.00607204923348372 0.0402242941898555 1.40434489727181 0.5 7.1 7 1 decreased myocardial infarction size 0.0195736228480292 0.0948186695900151 1.40434489727181 0.5 7.1 7 1 abnormal physiological neovascularization 0.0195736228480292 0.0948186695900151 1.40434489727181 0.5 7.1 7 1 abnormal incus morphology 0.0195736228480292 0.0948186695900151 1.40434489727181 0.5 7.1 7 1 abnormal interparietal bone morphology 0.0489987520318005 0.191191208908398 1.40434489727181 0.5 7.1 7 1 abnormal vasoconstriction 0.0489987520318005 0.191191208908398 1.40434489727181 0.5 7.1 7 1 megacephaly 0.0489987520318005 0.191191208908398 1.40434489727181 0.5 7.1 7 1 abnormal kidney blood vessel morphology 0.0489987520318005 0.191191208908398 1.40434489727181 0.5 7.1 7 1 translucent skin 0.0489987520318005 0.191191208908398 1.40434489727181 0.5 7.1 7 1 irregularly shaped pupil 0.0489987520318005 0.191191208908398 1.40434489727181 0.5 7.1 7 1 increased aggression towards males 0.0489987520318005 0.191191208908398 1.40434489727181 0.5 7.1 7 1 abnormal pinna reflex 0.0489987520318005 0.191191208908398 1.40434489727181 0.5 7.1 7 1 abnormal adrenal gland secretion 0.0489987520318005 0.191191208908398 1.40434489727181 0.5 7.1 7 1 abnormal fluid regulation 0.0489987520318005 0.191191208908398 1.40434489727181 0.5 7.1 7 1 increased lactate dehydrogenase level 0.0489987520318005 0.191191208908398 1.40434489727181 0.5 7.1 7 1 absent otoliths 0.0489987520318005 0.191191208908398 1.40434489727181 0.5 7.1 7 1 abnormal ventral body wall morphology 0.0489987520318005 0.191191208908398 1.40434489727181 0.5 7.1 7 1 abnormal uterus development 0.0489987520318005 0.191191208908398 1.40434489727181 0.5 7.1 7 1 vascular smooth muscle hypoplasia 0.0489987520318005 0.191191208908398 1.40434489727181 0.5 7.1 7 1 abnormal iris pigmentation 0.0489987520318005 0.191191208908398 1.40434489727181 0.5 7.1 7 1 increased circulating growth hormone level 0.0489987520318005 0.191191208908398 1.40434489727181 0.5 7.1 7 1 abnormal viscerocranium morphology 0.0489987520318005 0.191191208908398 1.40434489727181 0.5 7.1 7 1 decreased cornea thickness 0.0489987520318005 0.191191208908398 1.40434489727181 0.5 7.1 7 1 increased stomach tumor incidence 0.0489987520318005 0.191191208908398 1.40434489727181 0.5 7.1 7 1 decreased compact bone area 0.0489987520318005 0.191191208908398 1.40434489727181 0.5 7.1 7 1 absent maxillary shelf 0.0936264185851341 0.280428315750176 1.40434489727181 0.5 7.1 7 1 enlarged testis 0.0936264185851341 0.280428315750176 1.40434489727181 0.5 7.1 7 1 fused cornea and lens 0.0936264185851341 0.280428315750176 1.40434489727181 0.5 7.1 7 1 absent trophoblast giant cells 0.0936264185851341 0.280428315750176 1.40434489727181 0.5 7.1 7 1 abnormal primordial germ cell migration 0.0936264185851341 0.280428315750176 1.40434489727181 0.5 7.1 7 1 abnormal bone healing 0.0936264185851341 0.280428315750176 1.40434489727181 0.5 7.1 7 1 abnormal scala media morphology 0.0936264185851341 0.280428315750176 1.40434489727181 0.5 7.1 7 1 abnormal hindlimb zeugopod morphology 0.0936264185851341 0.280428315750176 1.40434489727181 0.5 7.1 7 1 absent pharyngeal arches 0.0936264185851341 0.280428315750176 1.40434489727181 0.5 7.1 7 1 abnormal ear physiology 0.0936264185851341 0.280428315750176 1.40434489727181 0.5 7.1 7 1 abnormal deltoid tuberosity morphology 0.0936264185851341 0.280428315750176 1.40434489727181 0.5 7.1 7 1 abnormal respiratory conducting tube morphology 0.0936264185851341 0.280428315750176 1.40434489727181 0.5 7.1 7 1 decreased cochlear inner hair cell number 0.0936264185851341 0.280428315750176 1.40434489727181 0.5 7.1 7 1 absent coat pigmentation 0.0936264185851341 0.280428315750176 1.40434489727181 0.5 7.1 7 1 abnormal corneal endothelium morphology 0.0936264185851341 0.280428315750176 1.40434489727181 0.5 7.1 7 1 vascular smooth muscle hyperplasia 0.0936264185851341 0.280428315750176 1.40434489727181 0.5 7.1 7 1 abnormal developmental vascular remodeling 0.0936264185851341 0.280428315750176 1.40434489727181 0.5 7.1 7 1 increased serotonin level 0.0936264185851341 0.280428315750176 1.40434489727181 0.5 7.1 7 1 acanthocytosis 0.0936264185851341 0.280428315750176 1.40434489727181 0.5 7.1 7 1 increased kidney iron level 0.0936264185851341 0.280428315750176 1.40434489727181 0.5 7.1 7 1 common ventricle 0.0936264185851341 0.280428315750176 1.40434489727181 0.5 7.1 7 1 abnormal left subclavian artery morphology 0.0936264185851341 0.280428315750176 1.40434489727181 0.5 7.1 7 1 sinus bradycardia 0.0936264185851341 0.280428315750176 1.40434489727181 0.5 7.1 7 1 fusion of atlas and odontoid process 0.0936264185851341 0.280428315750176 1.40434489727181 0.5 7.1 7 1 lethality during fetal growth through weaning, complete penetrance 0.0936264185851341 0.280428315750176 1.40434489727181 0.5 7.1 7 1 enlarged heart 8.51949238144061e-15 1.03376767311383e-12 1.40434489727181 0.5 7.1 7 1 abnormal cell morphology 5.07183100932792e-08 1.91154236904594e-06 1.40434489727181 0.5 7.1 7 1 abnormal cornea morphology 6.22962960034696e-06 0.000137744032274338 1.40434489727181 0.5 7.1 7 1 small seminiferous tubules 1.06751875612953e-05 0.000222213632290561 1.40434489727181 0.5 7.1 7 1 prenatal lethality 5.41313570408524e-05 0.000935081601660559 1.40434489727181 0.5 7.1 7 1 increased erythrocyte cell number 7.10469719596886e-05 0.0011665303151797 1.40434489727181 0.5 7.1 7 1 glomerulosclerosis 9.32910861256656e-05 0.00145038485460996 1.40434489727181 0.5 7.1 7 1 abnormal chondrocyte morphology 0.000161094752460062 0.00235028267885281 1.40434489727181 0.5 7.1 7 1 oligodactyly 0.000367143650292775 0.00467145693147456 1.40434489727181 0.5 7.1 7 1 abnormal cardiovascular system morphology 0.000367143650292775 0.00467145693147456 1.40434489727181 0.5 7.1 7 1 small heart 0.000367143650292775 0.00467145693147456 1.40434489727181 0.5 7.1 7 1 renal interstitial fibrosis 0.000638051472401184 0.0069156995102307 1.40434489727181 0.5 7.1 7 1 decreased threshold for auditory brainstem response 0.00147146680280966 0.013997222455025 1.40434489727181 0.5 7.1 7 1 renal hypoplasia 0.00194821730755349 0.0170941465698035 1.40434489727181 0.5 7.1 7 1 polydipsia 0.00342855210030012 0.0273788871572923 1.40434489727181 0.5 7.1 7 1 abnormal depression-related behavior 0.00342855210030012 0.0273788871572923 1.40434489727181 0.5 7.1 7 1 abnormal response to new environment 0.00455864727881117 0.0336618350542409 1.40434489727181 0.5 7.1 7 1 abnormal lactation 0.00455864727881117 0.0336618350542409 1.40434489727181 0.5 7.1 7 1 decreased body height 0.0108421624990018 0.0648314404237184 1.40434489727181 0.5 7.1 7 1 abnormal lung saccule morphology 0.0108421624990018 0.0648314404237184 1.40434489727181 0.5 7.1 7 1 abnormal enterocyte morphology 0.0145444360485796 0.0809379970264914 1.40434489727181 0.5 7.1 7 1 increased body size 0.0145444360485796 0.0809379970264914 1.40434489727181 0.5 7.1 7 1 decreased cardiac output 0.0145444360485796 0.0809379970264914 1.40434489727181 0.5 7.1 7 1 abnormal basement membrane morphology 0.0145444360485796 0.0809379970264914 1.40434489727181 0.5 7.1 7 1 abnormal blood-brain barrier function 0.0145444360485796 0.0809379970264914 1.40434489727181 0.5 7.1 7 1 abnormal occipital bone morphology 0.0145444360485796 0.0809379970264914 1.40434489727181 0.5 7.1 7 1 abnormal cerebral cortex pyramidal cell morphology 0.0145444360485796 0.0809379970264914 1.40434489727181 0.5 7.1 7 1 increased mammary gland tumor incidence 0.0145444360485796 0.0809379970264914 1.40434489727181 0.5 7.1 7 1 lowered ear position 0.0264430916391494 0.121922503155485 1.40434489727181 0.5 7.1 7 1 abnormal megakaryocyte differentiation 0.0264430916391494 0.121922503155485 1.40434489727181 0.5 7.1 7 1 blepharoptosis 0.0264430916391494 0.121922503155485 1.40434489727181 0.5 7.1 7 1 abnormal iron level 0.0264430916391494 0.121922503155485 1.40434489727181 0.5 7.1 7 1 abnormal thymus cortex morphology 0.0264430916391494 0.121922503155485 1.40434489727181 0.5 7.1 7 1 abnormal bile duct morphology 0.0264430916391494 0.121922503155485 1.40434489727181 0.5 7.1 7 1 abnormal pregnancy 0.0264430916391494 0.121922503155485 1.40434489727181 0.5 7.1 7 1 increased effector memory CD4-positive, alpha-beta T cell number 0.0264430916391494 0.121922503155485 1.40434489727181 0.5 7.1 7 1 abnormal aerobic respiration 0.0264430916391494 0.121922503155485 1.40434489727181 0.5 7.1 7 1 abnormal tympanic ring morphology 0.0358908394070376 0.155808835994775 1.40434489727181 0.5 7.1 7 1 decreased mast cell number 0.0358908394070376 0.155808835994775 1.40434489727181 0.5 7.1 7 1 disorganized retinal layers 0.0358908394070376 0.155808835994775 1.40434489727181 0.5 7.1 7 1 bowed tibia 0.0358908394070376 0.155808835994775 1.40434489727181 0.5 7.1 7 1 bowed radius 0.0358908394070376 0.155808835994775 1.40434489727181 0.5 7.1 7 1 increased cochlear outer hair cell number 0.0358908394070376 0.155808835994775 1.40434489727181 0.5 7.1 7 1 decreased skeletal muscle weight 0.0358908394070376 0.155808835994775 1.40434489727181 0.5 7.1 7 1 decreased fibroblast apoptosis 0.0358908394070376 0.155808835994775 1.40434489727181 0.5 7.1 7 1 abnormal thymus involution 0.0673955222537591 0.221245386369256 1.40434489727181 0.5 7.1 7 1 abnormal respiratory function 0.0673955222537591 0.221245386369256 1.40434489727181 0.5 7.1 7 1 loss of dopaminergic neurons 0.0673955222537591 0.221245386369256 1.40434489727181 0.5 7.1 7 1 delayed somite formation 0.0673955222537591 0.221245386369256 1.40434489727181 0.5 7.1 7 1 abnormal rostral-caudal body axis extension 0.0673955222537591 0.221245386369256 1.40434489727181 0.5 7.1 7 1 vestibular saccular macula degeneration 0.0673955222537591 0.221245386369256 1.40434489727181 0.5 7.1 7 1 abnormal cochlear outer hair cell physiology 0.0673955222537591 0.221245386369256 1.40434489727181 0.5 7.1 7 1 decreased keratinocyte proliferation 0.0673955222537591 0.221245386369256 1.40434489727181 0.5 7.1 7 1 hydrometra 0.0673955222537591 0.221245386369256 1.40434489727181 0.5 7.1 7 1 impaired behavioral response to cocaine 0.0673955222537591 0.221245386369256 1.40434489727181 0.5 7.1 7 1 decreased mammary gland epithelial cell proliferation 0.0673955222537591 0.221245386369256 1.40434489727181 0.5 7.1 7 1 increased fibrosarcoma incidence 0.0673955222537591 0.221245386369256 1.40434489727181 0.5 7.1 7 1 embryonic lethality between implantation and placentation, incomplete penetrance 0.0673955222537591 0.221245386369256 1.40434489727181 0.5 7.1 7 1 eyelids open at birth 0.000211865945358936 0.00291975921928174 1.40434489727181 0.5 7.1 7 1 abnormal ocular fundus morphology 0.00810433615932855 0.0511663355236796 1.40434489727181 0.5 7.1 7 1 anemia 2.29356178302992e-13 2.28209397411477e-11 1.39768923425156 0.497630331753554 7.1 7 1 increased circulating triglyceride level 1.40101036619564e-09 7.3368700756035e-08 1.39465976004924 0.496551724137931 7.1 7 1 neonatal lethality, incomplete penetrance 1.6802126055288e-15 2.19975202960679e-13 1.38273959115993 0.492307692307692 7.1 7 1 gliosis 7.98961805617959e-05 0.00127961288584982 1.38205370842622 0.492063492063492 7.1 7 1 increased tumor incidence 3.79285643225544e-08 1.46274889538534e-06 1.38169417312226 0.491935483870968 7.1 7 1 syndactyly 0.000137679381639806 0.00203250719186361 1.38054244138585 0.491525423728814 7.1 7 1 abnormal craniofacial bone morphology 0.000180862341968504 0.00257082900369516 1.37970726749511 0.491228070175439 7.1 7 1 increased hepatocellular carcinoma incidence 0.000180862341968504 0.00257082900369516 1.37970726749511 0.491228070175439 7.1 7 1 abnormal facial morphology 0.000180862341968504 0.00257082900369516 1.37970726749511 0.491228070175439 7.1 7 1 abnormal embryo turning 0.000237712805519454 0.00322240111024327 1.37881135368505 0.490909090909091 7.1 7 1 preweaning lethality, complete penetrance 5.22352256515376e-41 5.197404952328e-38 1.37777621002613 0.490540540540541 7.1 7 1 decreased bone mineral content 1.58910646223667e-12 1.37778927368849e-10 1.37733826463197 0.490384615384615 7.1 7 1 cachexia 5.41686275782765e-07 1.60410072739241e-05 1.37733826463197 0.490384615384615 7.1 7 1 impaired balance 7.07145966854269e-07 2.04537859598837e-05 1.3768087228155 0.490196078431373 7.1 7 1 abnormal gastrulation 0.000411345524597457 0.00507802477635819 1.3768087228155 0.490196078431373 7.1 7 1 abnormal craniofacial development 0.000541622151429316 0.00612402318945647 1.37568479732749 0.489795918367347 7.1 7 1 abnormal ectoderm development 0.000941063262006247 0.00985639942838121 1.37313723288799 0.488888888888889 7.1 7 1 hyperglycemia 4.58920551105852e-06 0.000107694799139227 1.37242796778836 0.488636363636364 7.1 7 1 impaired macrophage phagocytosis 0.00124196085726566 0.0122818574208686 1.37168571361432 0.488372093023256 7.1 7 1 abnormal double-strand DNA break repair 0.00124196085726566 0.0122818574208686 1.37168571361432 0.488372093023256 7.1 7 1 hemopericardium 0.00164056265179075 0.0153402657451572 1.3700925827042 0.48780487804878 7.1 7 1 palatal shelves fail to meet at midline 0.00164056265179075 0.0153402657451572 1.3700925827042 0.48780487804878 7.1 7 1 abnormal neural tube morphology 6.84024302204591e-10 3.91151827984809e-08 1.36966971462312 0.487654320987654 7.1 7 1 increased circulating alanine transaminase level 1.75562228428961e-05 0.000349368834573632 1.36833605375202 0.487179487179487 7.1 7 1 abnormal heart looping 0.00216926356210707 0.0187362608011852 1.36833605375202 0.487179487179487 7.1 7 1 abnormal iris morphology 0.00216926356210707 0.0187362608011852 1.36833605375202 0.487179487179487 7.1 7 1 abnormal circulating hormone level 0.00216926356210707 0.0187362608011852 1.36833605375202 0.487179487179487 7.1 7 1 decreased trabecular bone volume 0.00216926356210707 0.0187362608011852 1.36833605375202 0.487179487179487 7.1 7 1 abnormal branching of the mammary ductal tree 0.00287151422899293 0.0237305370253154 1.36638962977798 0.486486486486487 7.1 7 1 increased insulin secretion 0.00287151422899293 0.0237305370253154 1.36638962977798 0.486486486486487 7.1 7 1 abnormal calcium ion homeostasis 0.00287151422899293 0.0237305370253154 1.36638962977798 0.486486486486487 7.1 7 1 decreased circulating cholesterol level 7.07638031564335e-11 4.51346052183663e-09 1.36597481811138 0.486338797814208 7.1 7 1 decreased hematocrit 5.65611920687081e-09 2.65464085416814e-07 1.36586969460683 0.486301369863014 7.1 7 1 abnormal liver development 0.0038057508514888 0.0296765054641956 1.36422075734976 0.485714285714286 7.1 7 1 thick pulmonary interalveolar septum 0.0038057508514888 0.0296765054641956 1.36422075734976 0.485714285714286 7.1 7 1 ovary cysts 0.0038057508514888 0.0296765054641956 1.36422075734976 0.485714285714286 7.1 7 1 increased carcinoma incidence 0.0038057508514888 0.0296765054641956 1.36422075734976 0.485714285714286 7.1 7 1 abnormal midbrain development 0.0038057508514888 0.0296765054641956 1.36422075734976 0.485714285714286 7.1 7 1 decreased bone volume 0.0038057508514888 0.0296765054641956 1.36422075734976 0.485714285714286 7.1 7 1 decreased body weight 1.18938051212982e-65 5.91716804784583e-62 1.36350772739961 0.48546042003231 7.1 7 1 abnormal pulmonary alveolus morphology 1.33779230488867e-06 3.50290353516902e-05 1.36263168250136 0.485148514851485 7.1 7 1 decreased total body fat amount 2.00004711733855e-18 3.98009376350371e-16 1.36229864286247 0.48502994011976 7.1 7 1 abnormal ovarian folliculogenesis 0.00505080524114903 0.0353912057390372 1.36178899129387 0.484848484848485 7.1 7 1 decreased systemic arterial blood pressure 0.00505080524114903 0.0353912057390372 1.36178899129387 0.484848484848485 7.1 7 1 single kidney 0.00505080524114903 0.0353912057390372 1.36178899129387 0.484848484848485 7.1 7 1 abnormal QRS complex 0.00505080524114903 0.0353912057390372 1.36178899129387 0.484848484848485 7.1 7 1 improved glucose tolerance 2.1004702638746e-11 1.4718083891234e-09 1.36135474735532 0.48469387755102 7.1 7 1 cyanosis 3.55521529033671e-11 2.42290357115413e-09 1.36045911923206 0.484375 7.1 7 1 abnormal tooth morphology 0.000116190056941666 0.00177860164087627 1.36045911923206 0.484375 7.1 7 1 abnormal retinal photoreceptor layer morphology 0.00671340034396041 0.0438523926528208 1.35904344897272 0.483870967741935 7.1 7 1 small cranium 0.00671340034396041 0.0438523926528208 1.35904344897272 0.483870967741935 7.1 7 1 abnormal mitochondrial ATP synthesis coupled electron transport 0.00671340034396041 0.0438523926528208 1.35904344897272 0.483870967741935 7.1 7 1 increased startle reflex 6.63234886659892e-06 0.000145356544543302 1.35700742882444 0.48314606741573 7.1 7 1 thrombocytopenia 1.05973339165754e-08 4.70729787812167e-07 1.35591921115899 0.482758620689655 7.1 7 1 decreased granulocyte number 0.00893861356781259 0.0551048358114841 1.35591921115899 0.482758620689655 7.1 7 1 abnormal spinal nerve morphology 0.00893861356781259 0.0551048358114841 1.35591921115899 0.482758620689655 7.1 7 1 decreased body size 2.47741620701236e-41 3.08128640747162e-38 1.35506963771841 0.482456140350877 7.1 7 1 postnatal growth retardation 8.07271581995595e-32 5.02022015053511e-29 1.35386191076857 0.48202614379085 7.1 7 1 abnormal eye morphology 2.33932366877938e-08 9.53945512473559e-07 1.35382889377282 0.482014388489209 7.1 7 1 postnatal lethality 1.08823173770591e-09 5.82145472589989e-08 1.35358544315355 0.481927710843373 7.1 7 1 abnormal long bone epiphyseal plate proliferative zone 0.000453297596410244 0.00542895239865676 1.35233212329878 0.481481481481481 7.1 7 1 rectal prolapse 0.0119246142457961 0.0709628658765974 1.35233212329878 0.481481481481481 7.1 7 1 thin epidermis 0.0119246142457961 0.0709628658765974 1.35233212329878 0.481481481481481 7.1 7 1 abnormal bone trabecula morphology 0.0119246142457961 0.0709628658765974 1.35233212329878 0.481481481481481 7.1 7 1 decreased double-positive T cell number 2.50591378058831e-06 6.26478445147076e-05 1.34817110138094 0.48 7.1 7 1 spleen hyperplasia 4.329556402786e-05 0.000794817088703334 1.34817110138094 0.48 7.1 7 1 abnormal limb morphology 4.329556402786e-05 0.000794817088703334 1.34817110138094 0.48 7.1 7 1 abnormal hindlimb morphology 0.000784219674358425 0.00831874814484683 1.34817110138094 0.48 7.1 7 1 increased circulating chloride level 0.000784219674358425 0.00831874814484683 1.34817110138094 0.48 7.1 7 1 abnormal vertebrae development 0.0159436452441691 0.0867071846456475 1.34817110138094 0.48 7.1 7 1 abnormal energy expenditure 0.0159436452441691 0.0867071846456475 1.34817110138094 0.48 7.1 7 1 impaired glucose tolerance 1.61265859119578e-13 1.63734214106103e-11 1.34771808689795 0.479838709677419 7.1 7 1 respiratory distress 7.06002784289252e-10 3.99132255890799e-08 1.34752169333596 0.479768786127168 7.1 7 1 decreased percent body fat/body weight 5.6655354046446e-05 0.000975295454605775 1.34663209327434 0.479452054794521 7.1 7 1 decreased grip strength 4.44884489749967e-12 3.40507744077859e-10 1.34663209327434 0.479452054794521 7.1 7 1 abnormal phalanx morphology 0.0010324558637666 0.010634509155774 1.34583052655215 0.479166666666667 7.1 7 1 atelectasis 7.41576081715122e-05 0.00120566699559893 1.34500638048568 0.47887323943662 7.1 7 1 corneal opacity 7.41576081715122e-05 0.00120566699559893 1.34500638048568 0.47887323943662 7.1 7 1 decreased startle reflex 4.28158535378269e-07 1.27550222365682e-05 1.34433015807216 0.478632478632479 7.1 7 1 hypotension 0.0213722858025242 0.103030156848409 1.34328642347738 0.478260869565217 7.1 7 1 abnormal postnatal growth 0.0213722858025242 0.103030156848409 1.34328642347738 0.478260869565217 7.1 7 1 abnormal Wolffian duct morphology 0.0213722858025242 0.103030156848409 1.34328642347738 0.478260869565217 7.1 7 1 abnormal chondrocyte physiology 0.0213722858025242 0.103030156848409 1.34328642347738 0.478260869565217 7.1 7 1 abnormal vertebral artery topology 0.0213722858025242 0.103030156848409 1.34328642347738 0.478260869565217 7.1 7 1 respiratory failure 1.27201902729592e-08 5.55113566736598e-07 1.33924281594133 0.47682119205298 7.1 7 1 decreased susceptibility to hepatic steatosis 0.00021833787799322 0.00299237174384648 1.33747133073506 0.476190476190476 7.1 7 1 skin edema 0.00236636816043507 0.0201883100557714 1.33747133073506 0.476190476190476 7.1 7 1 abnormal reproductive system morphology 0.00236636816043507 0.0201883100557714 1.33747133073506 0.476190476190476 7.1 7 1 complete atrioventricular septal defect 0.0287358036612517 0.132004268896332 1.33747133073506 0.476190476190476 7.1 7 1 embryonic lethality at implantation, complete penetrance 0.0287358036612517 0.132004268896332 1.33747133073506 0.476190476190476 7.1 7 1 abnormal blood vessel morphology 2.79917944660239e-08 1.11407341974775e-06 1.33654893671386 0.475862068965517 7.1 7 1 increased susceptibility to weight loss 0.00312525644854247 0.0253640307202264 1.33412765240822 0.475 7.1 7 1 abnormal behavior 2.16782514857392e-14 2.5678405033703e-12 1.33362249237323 0.474820143884892 7.1 7 1 decreased leukocyte cell number 8.01349968090623e-08 2.93140889062562e-06 1.3325900485061 0.474452554744526 7.1 7 1 absent gastric milk in neonates 4.71169898512489e-05 0.00084319073564735 1.33232721023223 0.474358974358974 7.1 7 1 decreased hair follicle number 0.00413155691255785 0.0313330726219136 1.33043200794171 0.473684210526316 7.1 7 1 abnormal compact bone morphology 0.00413155691255785 0.0313330726219136 1.33043200794171 0.473684210526316 7.1 7 1 short vibrissae 0.038774456525296 0.167015516202033 1.33043200794171 0.473684210526316 7.1 7 1 stereotypic behavior 0.038774456525296 0.167015516202033 1.33043200794171 0.473684210526316 7.1 7 1 abnormal metatarsal bone morphology 0.038774456525296 0.167015516202033 1.33043200794171 0.473684210526316 7.1 7 1 increased circulating VLDL cholesterol level 0.038774456525296 0.167015516202033 1.33043200794171 0.473684210526316 7.1 7 1 decreased susceptibility to weight gain 0.038774456525296 0.167015516202033 1.33043200794171 0.473684210526316 7.1 7 1 thin interventricular septum 0.038774456525296 0.167015516202033 1.33043200794171 0.473684210526316 7.1 7 1 abnormal angiogenesis 8.05062981449236e-05 0.00127961288584982 1.32843436228414 0.472972972972973 7.1 7 1 pale liver 8.05062981449236e-05 0.00127961288584982 1.32843436228414 0.472972972972973 7.1 7 1 short snout 2.27397994212635e-06 5.80156421132235e-05 1.32632573631226 0.472222222222222 7.1 7 1 abnormal uterus morphology 0.00546775454869409 0.0374695727491016 1.32632573631226 0.472222222222222 7.1 7 1 abnormal limb bone morphology 0.00546775454869409 0.0374695727491016 1.32632573631226 0.472222222222222 7.1 7 1 premature death 1.42685187408801e-40 1.18309801226464e-37 1.3244228299474 0.471544715447154 7.1 7 1 postnatal lethality, complete penetrance 7.07414968338111e-19 1.46641227811754e-16 1.32430451452575 0.471502590673575 7.1 7 1 domed cranium 0.00013767710252833 0.00203250719186361 1.32409661742771 0.471428571428571 7.1 7 1 embryonic lethality between somite formation and embryo turning, complete penetrance 0.00013767710252833 0.00203250719186361 1.32409661742771 0.471428571428571 7.1 7 1 cataract 6.57253660837469e-07 1.92343350745083e-05 1.32310180404121 0.471074380165289 7.1 7 1 impaired synaptic plasticity 0.00724469945954254 0.0468082854691223 1.32173637390288 0.470588235294118 7.1 7 1 absence seizures 0.052545104214201 0.203117244340055 1.32173637390288 0.470588235294118 7.1 7 1 abnormal embryonic-extraembryonic boundary morphology 0.052545104214201 0.203117244340055 1.32173637390288 0.470588235294118 7.1 7 1 abnormal ectoplacental cone morphology 0.052545104214201 0.203117244340055 1.32173637390288 0.470588235294118 7.1 7 1 abnormal tarsal bone morphology 0.052545104214201 0.203117244340055 1.32173637390288 0.470588235294118 7.1 7 1 decreased body fat mass 0.052545104214201 0.203117244340055 1.32173637390288 0.470588235294118 7.1 7 1 abnormal extraembryonic tissue morphology 5.02427282746053e-06 0.000116259336356354 1.32173637390288 0.470588235294118 7.1 7 1 postnatal lethality, incomplete penetrance 8.70230627672857e-27 4.32939737267247e-24 1.32028199849145 0.470070422535211 7.1 7 1 decreased circulating glucose level 7.79045245138715e-14 8.07447936367731e-12 1.31877549492908 0.469534050179211 7.1 7 1 abnormal epidermis stratum corneum morphology 0.00146665491698805 0.0139791642969565 1.31836459743884 0.469387755102041 7.1 7 1 increased sarcoma incidence 0.00146665491698805 0.0139791642969565 1.31836459743884 0.469387755102041 7.1 7 1 increased exploration in new environment 5.08197058756566e-05 0.000890239565955604 1.31765694065009 0.469135802469136 7.1 7 1 abnormal skeleton development 5.08197058756566e-05 0.000890239565955604 1.31765694065009 0.469135802469136 7.1 7 1 increased blood urea nitrogen level 7.19743093813293e-08 2.6523865864601e-06 1.31717866226873 0.468965517241379 7.1 7 1 increased circulating insulin level 1.614012216145e-08 6.92216446148392e-07 1.31657334119232 0.46875 7.1 7 1 increased sacral vertebrae number 0.000308468308332825 0.00406405785310724 1.31657334119232 0.46875 7.1 7 1 abnormal vertebral body morphology 0.00961179585307241 0.0591083861174725 1.31657334119232 0.46875 7.1 7 1 cleft secondary palate 1.44706120060629e-05 0.000292177201848597 1.31470586127574 0.468085106382979 7.1 7 1 abnormal innervation 0.00192917342449669 0.016986969534285 1.31470586127574 0.468085106382979 7.1 7 1 abnormal neurocranium morphology 0.000113065690497353 0.00173611669822325 1.31072190412035 0.466666666666667 7.1 7 1 increased circulating corticosterone level 0.00253911286307585 0.021302000832719 1.31072190412035 0.466666666666667 7.1 7 1 abnormal cell migration 0.00253911286307585 0.021302000832719 1.31072190412035 0.466666666666667 7.1 7 1 liver hemorrhage 0.0127710840706888 0.0746827850846695 1.31072190412035 0.466666666666667 7.1 7 1 abnormal brain vasculature morphology 0.0127710840706888 0.0746827850846695 1.31072190412035 0.466666666666667 7.1 7 1 abnormal fat pad morphology 0.0127710840706888 0.0746827850846695 1.31072190412035 0.466666666666667 7.1 7 1 absent incisors 0.0715819580849286 0.228135965068879 1.31072190412035 0.466666666666667 7.1 7 1 abnormal prostate gland morphology 0.0715819580849286 0.228135965068879 1.31072190412035 0.466666666666667 7.1 7 1 abnormal pup retrieval 0.0715819580849286 0.228135965068879 1.31072190412035 0.466666666666667 7.1 7 1 immune system phenotype 0.0715819580849286 0.228135965068879 1.31072190412035 0.466666666666667 7.1 7 1 abnormal energy homeostasis 0.0715819580849286 0.228135965068879 1.31072190412035 0.466666666666667 7.1 7 1 decreased thymocyte apoptosis 0.0715819580849286 0.228135965068879 1.31072190412035 0.466666666666667 7.1 7 1 abnormal secondary palate development 0.0715819580849286 0.228135965068879 1.31072190412035 0.466666666666667 7.1 7 1 abnormal aorta wall morphology 0.0715819580849286 0.228135965068879 1.31072190412035 0.466666666666667 7.1 7 1 decreased brown adipose tissue mass 0.0715819580849286 0.228135965068879 1.31072190412035 0.466666666666667 7.1 7 1 abnormal brain morphology 2.24788173195846e-08 9.24232364999451e-07 1.30839586702342 0.46583850931677 7.1 7 1 abnormal motor coordination/ balance 1.18924266269455e-05 0.000245497188668273 1.3050477833233 0.464646464646465 7.1 7 1 abnormal coat/hair pigmentation 3.41160351361407e-06 8.23918809719903e-05 1.30403454746668 0.464285714285714 7.1 7 1 abnormal ovulation 0.0169968372564668 0.0911559463381162 1.30403454746668 0.464285714285714 7.1 7 1 microcephaly 0.000251902995074871 0.00339625311787936 1.3025807742811 0.463768115942029 7.1 7 1 abnormal embryo development 3.6928983874103e-07 1.12712696180161e-05 1.30108424306065 0.463235294117647 7.1 7 1 increased cell proliferation 0.00119034920234806 0.0119394904872613 1.30031934932575 0.462962962962963 7.1 7 1 abnormal small intestine morphology 0.00119034920234806 0.0119394904872613 1.30031934932575 0.462962962962963 7.1 7 1 neurodegeneration 0.00119034920234806 0.0119394904872613 1.30031934932575 0.462962962962963 7.1 7 1 abnormal osteoblast physiology 0.00119034920234806 0.0119394904872613 1.30031934932575 0.462962962962963 7.1 7 1 reduced male fertility 6.60898922647781e-11 4.27009368853599e-09 1.29917369351136 0.462555066079295 7.1 7 1 impaired coordination 8.05963053133829e-16 1.11379616370578e-13 1.29881608996237 0.46242774566474 7.1 7 1 decreased kidney weight 0.00156104724102997 0.0146532264606115 1.29631836671244 0.461538461538462 7.1 7 1 increased susceptibility to injury 0.00156104724102997 0.0146532264606115 1.29631836671244 0.461538461538462 7.1 7 1 abnormal kidney cortex morphology 0.0226630530311753 0.108516543628582 1.29631836671244 0.461538461538462 7.1 7 1 abnormal ureter morphology 0.0226630530311753 0.108516543628582 1.29631836671244 0.461538461538462 7.1 7 1 abnormal Schwann cell morphology 0.0226630530311753 0.108516543628582 1.29631836671244 0.461538461538462 7.1 7 1 increased leukemia incidence 0.0226630530311753 0.108516543628582 1.29631836671244 0.461538461538462 7.1 7 1 abnormal membranous labyrinth morphology 0.0981615438376379 0.289143236570739 1.29631836671244 0.461538461538462 7.1 7 1 short premaxilla 0.0981615438376379 0.289143236570739 1.29631836671244 0.461538461538462 7.1 7 1 abnormal bile duct development 0.0981615438376379 0.289143236570739 1.29631836671244 0.461538461538462 7.1 7 1 abnormal coping response 0.0981615438376379 0.289143236570739 1.29631836671244 0.461538461538462 7.1 7 1 absent lateral semicircular canal 0.0981615438376379 0.289143236570739 1.29631836671244 0.461538461538462 7.1 7 1 abnormal GABAergic neuron morphology 0.0981615438376379 0.289143236570739 1.29631836671244 0.461538461538462 7.1 7 1 abnormal vestibulocochlear ganglion morphology 0.0981615438376379 0.289143236570739 1.29631836671244 0.461538461538462 7.1 7 1 abnormal retinal inner plexiform layer morphology 0.0981615438376379 0.289143236570739 1.29631836671244 0.461538461538462 7.1 7 1 small otic vesicle 0.0981615438376379 0.289143236570739 1.29631836671244 0.461538461538462 7.1 7 1 increased cochlear inner hair cell number 0.0981615438376379 0.289143236570739 1.29631836671244 0.461538461538462 7.1 7 1 increased circulating thyroxine level 0.0981615438376379 0.289143236570739 1.29631836671244 0.461538461538462 7.1 7 1 increased renin activity 0.0981615438376379 0.289143236570739 1.29631836671244 0.461538461538462 7.1 7 1 decreased lymphocyte cell number 1.04685251887548e-06 2.79778078151962e-05 1.29463045217245 0.4609375 7.1 7 1 ataxia 1.06447884476397e-09 5.75628505728342e-08 1.29310965788394 0.46039603960396 7.1 7 1 short stride length 0.00204798864219104 0.0179064033302292 1.29199730549006 0.46 7.1 7 1 increased granulocyte number 0.000204718563571472 0.00283697730854617 1.29047909479031 0.459459459459459 7.1 7 1 increased trabecular bone volume 0.0076745588204401 0.0495213101578333 1.29047909479031 0.459459459459459 7.1 7 1 abnormal long bone morphology 0.000734799500733438 0.00789552379297809 1.28923465979051 0.459016393442623 7.1 7 1 increased osteoclast cell number 0.000734799500733438 0.00789552379297809 1.28923465979051 0.459016393442623 7.1 7 1 decreased bone mineral density 4.05143122700295e-12 3.19934450068883e-10 1.28819607118166 0.458646616541353 7.1 7 1 abnormal malleus morphology 0.0302823901362738 0.138215496264186 1.28731615583249 0.458333333333333 7.1 7 1 abnormal foregut morphology 0.0302823901362738 0.138215496264186 1.28731615583249 0.458333333333333 7.1 7 1 hemolytic anemia 0.0302823901362738 0.138215496264186 1.28731615583249 0.458333333333333 7.1 7 1 increased body temperature 0.0302823901362738 0.138215496264186 1.28731615583249 0.458333333333333 7.1 7 1 hyperactivity 2.99074717112485e-16 4.25113347895603e-14 1.2870007144809 0.45822102425876 7.1 7 1 increased hemoglobin content 0.000960752835647947 0.0100414818431692 1.28533261784199 0.457627118644068 7.1 7 1 increased red blood cell distribution width 0.0101406561821141 0.0616745287359631 1.28397247750565 0.457142857142857 7.1 7 1 abnormal retina morphology 9.23036377066536e-10 5.10233997322891e-08 1.28397247750565 0.457142857142857 7.1 7 1 spleen hypoplasia 1.33913099045753e-05 0.000271925578674539 1.28397247750565 0.457142857142857 7.1 7 1 abnormal locomotor behavior 4.69187399547625e-05 0.00084319073564735 1.28222794968296 0.456521739130435 7.1 7 1 abnormal inner ear morphology 0.00352939135685689 0.0278709873021635 1.28222794968296 0.456521739130435 7.1 7 1 incomplete embryo turning 0.00125644519832465 0.0123533890546741 1.28115674838832 0.456140350877193 7.1 7 1 decreased circulating alanine transaminase level 0.000453958632731902 0.00542895239865676 1.28043211221841 0.455882352941176 7.1 7 1 polyuria 0.000215696250855431 0.00296433383427009 1.27667717933801 0.454545454545455 7.1 7 1 abnormal vascular development 0.000592066632126162 0.00652546227908663 1.27667717933801 0.454545454545455 7.1 7 1 hypertension 0.00463641135718128 0.0336618350542409 1.27667717933801 0.454545454545455 7.1 7 1 omphalocele 0.00463641135718128 0.0336618350542409 1.27667717933801 0.454545454545455 7.1 7 1 abnormal amino acid level 0.00463641135718128 0.0336618350542409 1.27667717933801 0.454545454545455 7.1 7 1 embryonic lethality, incomplete penetrance 0.00463641135718128 0.0336618350542409 1.27667717933801 0.454545454545455 7.1 7 1 enlarged pericardium 0.0134126213630086 0.0773207314959069 1.27667717933801 0.454545454545455 7.1 7 1 abnormal middle ear ossicle morphology 0.0134126213630086 0.0773207314959069 1.27667717933801 0.454545454545455 7.1 7 1 head tossing 0.0134126213630086 0.0773207314959069 1.27667717933801 0.454545454545455 7.1 7 1 abnormal basisphenoid bone morphology 0.0405619433384783 0.172474930007632 1.27667717933801 0.454545454545455 7.1 7 1 intestinal inflammation 0.0405619433384783 0.172474930007632 1.27667717933801 0.454545454545455 7.1 7 1 aphakia 0.0405619433384783 0.172474930007632 1.27667717933801 0.454545454545455 7.1 7 1 abnormal vascular branching morphogenesis 0.0405619433384783 0.172474930007632 1.27667717933801 0.454545454545455 7.1 7 1 abnormal cochlear sensory epithelium morphology 0.0405619433384783 0.172474930007632 1.27667717933801 0.454545454545455 7.1 7 1 abnormal circulating lipid level 0.0405619433384783 0.172474930007632 1.27667717933801 0.454545454545455 7.1 7 1 decreased susceptibility to viral infection induced morbidity/mortality 0.0405619433384783 0.172474930007632 1.27667717933801 0.454545454545455 7.1 7 1 abnormal sperm midpiece morphology 0.0405619433384783 0.172474930007632 1.27667717933801 0.454545454545455 7.1 7 1 pulmonary vascular congestion 0.0405619433384783 0.172474930007632 1.27667717933801 0.454545454545455 7.1 7 1 abnormal awl hair morphology 0.135763691089109 0.357178404636869 1.27667717933801 0.454545454545455 7.1 7 1 abnormal stomach epithelium morphology 0.135763691089109 0.357178404636869 1.27667717933801 0.454545454545455 7.1 7 1 abnormal sebaceous gland morphology 0.135763691089109 0.357178404636869 1.27667717933801 0.454545454545455 7.1 7 1 abnormal glossopharyngeal ganglion morphology 0.135763691089109 0.357178404636869 1.27667717933801 0.454545454545455 7.1 7 1 abnormal hemoglobin 0.135763691089109 0.357178404636869 1.27667717933801 0.454545454545455 7.1 7 1 impaired myelopoiesis 0.135763691089109 0.357178404636869 1.27667717933801 0.454545454545455 7.1 7 1 failure of somite differentiation 0.135763691089109 0.357178404636869 1.27667717933801 0.454545454545455 7.1 7 1 vasculitis 0.135763691089109 0.357178404636869 1.27667717933801 0.454545454545455 7.1 7 1 abnormal fear/anxiety-related behavior 0.135763691089109 0.357178404636869 1.27667717933801 0.454545454545455 7.1 7 1 abnormal larynx morphology 0.135763691089109 0.357178404636869 1.27667717933801 0.454545454545455 7.1 7 1 retinal detachment 0.135763691089109 0.357178404636869 1.27667717933801 0.454545454545455 7.1 7 1 fused joints 0.135763691089109 0.357178404636869 1.27667717933801 0.454545454545455 7.1 7 1 rectal hemorrhage 0.135763691089109 0.357178404636869 1.27667717933801 0.454545454545455 7.1 7 1 enlarged placenta 0.135763691089109 0.357178404636869 1.27667717933801 0.454545454545455 7.1 7 1 increased circulating triiodothyronine level 0.135763691089109 0.357178404636869 1.27667717933801 0.454545454545455 7.1 7 1 enhanced behavioral response to addictive substance 0.135763691089109 0.357178404636869 1.27667717933801 0.454545454545455 7.1 7 1 decreased palatine bone horizontal plate size 0.135763691089109 0.357178404636869 1.27667717933801 0.454545454545455 7.1 7 1 increased subcutaneous adipose tissue amount 0.135763691089109 0.357178404636869 1.27667717933801 0.454545454545455 7.1 7 1 increased pancreatic beta cell proliferation 0.135763691089109 0.357178404636869 1.27667717933801 0.454545454545455 7.1 7 1 decreased embryonic cilium length 0.135763691089109 0.357178404636869 1.27667717933801 0.454545454545455 7.1 7 1 thin hypoglossal nerve 0.135763691089109 0.357178404636869 1.27667717933801 0.454545454545455 7.1 7 1 abnormal joint morphology 0.00164348977732036 0.0153402657451572 1.27667717933801 0.454545454545455 7.1 7 1 abnormal trabecular bone morphology 5.25069298075054e-06 0.000120378790687714 1.27453150340635 0.453781512605042 7.1 7 1 decreased T cell number 1.34156319351588e-07 4.66732649492413e-06 1.27350531056947 0.453416149068323 7.1 7 1 abnormal mesoderm development 0.00215022707608389 0.018701712768387 1.27185952960466 0.452830188679245 7.1 7 1 abnormal placenta development 0.00215022707608389 0.018701712768387 1.27185952960466 0.452830188679245 7.1 7 1 enlarged kidney 0.00215022707608389 0.018701712768387 1.27185952960466 0.452830188679245 7.1 7 1 hydronephrosis 0.000133750623252489 0.00199224356491357 1.2705977641983 0.452380952380952 7.1 7 1 lethargy 6.39746071864814e-05 0.00107162852105301 1.26844055237454 0.451612903225806 7.1 7 1 osteopetrosis 0.017759764786818 0.0911559463381162 1.26844055237454 0.451612903225806 7.1 7 1 inner cell mass degeneration 0.017759764786818 0.0911559463381162 1.26844055237454 0.451612903225806 7.1 7 1 abnormal podocyte morphology 0.017759764786818 0.0911559463381162 1.26844055237454 0.451612903225806 7.1 7 1 preaxial polydactyly 0.017759764786818 0.0911559463381162 1.26844055237454 0.451612903225806 7.1 7 1 abnormal cell proliferation 0.0544842295339691 0.20898923818928 1.26391040754463 0.45 7.1 7 1 absent placental labyrinth 0.0544842295339691 0.20898923818928 1.26391040754463 0.45 7.1 7 1 abnormal optic stalk morphology 0.0544842295339691 0.20898923818928 1.26391040754463 0.45 7.1 7 1 decreased circulating VLDL cholesterol level 0.0544842295339691 0.20898923818928 1.26391040754463 0.45 7.1 7 1 abnormal sperm mitochondrial sheath morphology 0.0544842295339691 0.20898923818928 1.26391040754463 0.45 7.1 7 1 abnormal incisor morphology 0.00131408141588182 0.0128692028425434 1.26391040754463 0.45 7.1 7 1 abnormal respiratory system physiology 0.0036830510837018 0.0289923720592032 1.2610443975502 0.448979591836735 7.1 7 1 reduced female fertility 7.40824211647253e-10 4.14112410443268e-08 1.25906783893335 0.448275862068966 7.1 7 1 hypoactivity 4.4104681086378e-15 5.48551971011826e-13 1.25906783893335 0.448275862068966 7.1 7 1 enlarged spleen 7.75441244038992e-12 5.75794058073729e-10 1.25805897047266 0.447916666666667 7.1 7 1 abnormal reproductive system physiology 0.010542703222059 0.0632689367065665 1.25651911861162 0.447368421052632 7.1 7 1 decreased total retina thickness 0.010542703222059 0.0632689367065665 1.25651911861162 0.447368421052632 7.1 7 1 abnormal motor capabilities/coordination/movement 3.58634351562989e-06 8.57791297608592e-05 1.25539922634904 0.446969696969697 7.1 7 1 abnormal cell nucleus morphology 0.00482187507145549 0.034075040455243 1.25494650394502 0.446808510638298 7.1 7 1 neuron degeneration 0.00482187507145549 0.034075040455243 1.25494650394502 0.446808510638298 7.1 7 1 abnormal eye development 0.00223661403984971 0.0192844971373523 1.25387937256412 0.446428571428571 7.1 7 1 short tail 0.00023483727750445 0.00319211873110557 1.25206653491703 0.44578313253012 7.1 7 1 neonatal lethality, complete penetrance 2.02867068143767e-17 3.46455297556726e-15 1.25035971116744 0.445175438596491 7.1 7 1 abnormal cochlea morphology 0.00291812937507258 0.0239961878363406 1.24830657535272 0.444444444444444 7.1 7 1 abnormal mandible morphology 0.00291812937507258 0.0239961878363406 1.24830657535272 0.444444444444444 7.1 7 1 abnormal neuronal precursor proliferation 0.00291812937507258 0.0239961878363406 1.24830657535272 0.444444444444444 7.1 7 1 small placenta 0.00631425015246567 0.0416623269343723 1.24830657535272 0.444444444444444 7.1 7 1 lethality at weaning, complete penetrance 0.00631425015246567 0.0416623269343723 1.24830657535272 0.444444444444444 7.1 7 1 reduced long term depression 0.0138789774888502 0.0795370104800254 1.24830657535272 0.444444444444444 7.1 7 1 narrow eye opening 0.0138789774888502 0.0795370104800254 1.24830657535272 0.444444444444444 7.1 7 1 abnormal palate morphology 0.0312538040594787 0.141997876891239 1.24830657535272 0.444444444444444 7.1 7 1 abnormal skin appearance 0.0312538040594787 0.141997876891239 1.24830657535272 0.444444444444444 7.1 7 1 delayed kidney development 0.0734267142742426 0.230908914990112 1.24830657535272 0.444444444444444 7.1 7 1 right pulmonary isomerism 0.0734267142742426 0.230908914990112 1.24830657535272 0.444444444444444 7.1 7 1 abnormal radius morphology 0.0734267142742426 0.230908914990112 1.24830657535272 0.444444444444444 7.1 7 1 abnormal retinal rod cell morphology 0.0734267142742426 0.230908914990112 1.24830657535272 0.444444444444444 7.1 7 1 thick dermal layer 0.0734267142742426 0.230908914990112 1.24830657535272 0.444444444444444 7.1 7 1 eye inflammation 0.0734267142742426 0.230908914990112 1.24830657535272 0.444444444444444 7.1 7 1 abnormal thyroid cartilage morphology 0.0734267142742426 0.230908914990112 1.24830657535272 0.444444444444444 7.1 7 1 decreased cellular sensitivity to gamma-irradiation 0.0734267142742426 0.230908914990112 1.24830657535272 0.444444444444444 7.1 7 1 absent ureter 0.0734267142742426 0.230908914990112 1.24830657535272 0.444444444444444 7.1 7 1 abnormal eye anterior chamber morphology 0.0734267142742426 0.230908914990112 1.24830657535272 0.444444444444444 7.1 7 1 jerky movement 0.0734267142742426 0.230908914990112 1.24830657535272 0.444444444444444 7.1 7 1 decreased pulmonary respiratory rate 0.0734267142742426 0.230908914990112 1.24830657535272 0.444444444444444 7.1 7 1 decreased tumor latency 0.0734267142742426 0.230908914990112 1.24830657535272 0.444444444444444 7.1 7 1 abnormal gait 4.41535787059634e-12 3.40507744077859e-10 1.24527670502419 0.44336569579288 7.1 7 1 decreased B cell proliferation 0.000394655504685195 0.00489628712171781 1.24435623808894 0.443037974683544 7.1 7 1 small testis 8.07048644012986e-11 5.08236329615773e-09 1.24152230048667 0.442028985507246 7.1 7 1 abnormal organ of Corti morphology 0.00827034439152244 0.0520822320858534 1.24104897898439 0.441860465116279 7.1 7 1 abnormal homeostasis 0.00827034439152244 0.0520822320858534 1.24104897898439 0.441860465116279 7.1 7 1 kinked tail 7.17088070931608e-05 0.00117352406344893 1.23912785053395 0.441176470588235 7.1 7 1 short maxilla 0.0182820333920607 0.0911559463381162 1.23912785053395 0.441176470588235 7.1 7 1 overexpanded pulmonary alveoli 0.0182820333920607 0.0911559463381162 1.23912785053395 0.441176470588235 7.1 7 1 thin skin 0.0182820333920607 0.0911559463381162 1.23912785053395 0.441176470588235 7.1 7 1 abnormal spleen red pulp morphology 0.0182820333920607 0.0911559463381162 1.23912785053395 0.441176470588235 7.1 7 1 abnormal cranium morphology 6.40045494496455e-06 0.000140894970580525 1.23666192446323 0.440298507462687 7.1 7 1 abnormal axon extension 0.00496774300203168 0.0350560587732023 1.23582350959919 0.44 7.1 7 1 abnormal inner ear vestibule morphology 0.0415485468372135 0.175184443438881 1.23582350959919 0.44 7.1 7 1 mandible hypoplasia 0.0415485468372135 0.175184443438881 1.23582350959919 0.44 7.1 7 1 abnormal nest building behavior 0.0415485468372135 0.175184443438881 1.23582350959919 0.44 7.1 7 1 decreased placenta weight 0.0415485468372135 0.175184443438881 1.23582350959919 0.44 7.1 7 1 increased liver glycogen level 0.0415485468372135 0.175184443438881 1.23582350959919 0.44 7.1 7 1 abnormal tail morphology 0.00140516264445402 0.0137341535484455 1.23412127336007 0.439393939393939 7.1 7 1 Leydig cell hyperplasia 0.0108347253773706 0.0648314404237184 1.23308332443378 0.439024390243902 7.1 7 1 reduced fertility 5.12466960258424e-06 0.000118033478115077 1.23259048537526 0.438848920863309 7.1 7 1 seizures 3.5470456379225e-05 0.000658453434651657 1.23188148883492 0.43859649122807 7.1 7 1 increased macrophage cell number 0.00300237094729117 0.0245670978006144 1.23188148883492 0.43859649122807 7.1 7 1 abnormal retinal pigment epithelium morphology 0.000526033717258588 0.00599718822286144 1.22880178511283 0.4375 7.1 7 1 increased circulating cholesterol level 3.74421549964347e-07 1.13582147016624e-05 1.22880178511283 0.4375 7.1 7 1 abnormal osteoclast physiology 0.00182341555942984 0.0164388803412457 1.22880178511283 0.4375 7.1 7 1 abnormal osteoclast morphology 0.00648160667570364 0.04270992478361 1.22880178511283 0.4375 7.1 7 1 kidney cortex cysts 0.0240970739575092 0.113957170093734 1.22880178511283 0.4375 7.1 7 1 neonatal lethality 0.0240970739575092 0.113957170093734 1.22880178511283 0.4375 7.1 7 1 abnormal lumbar vertebrae morphology 0.0240970739575092 0.113957170093734 1.22880178511283 0.4375 7.1 7 1 abnormal bone marrow cell number 0.0993417170566216 0.289528437232978 1.22880178511283 0.4375 7.1 7 1 abnormal hair follicle orientation 0.0993417170566216 0.289528437232978 1.22880178511283 0.4375 7.1 7 1 delayed hair appearance 0.0993417170566216 0.289528437232978 1.22880178511283 0.4375 7.1 7 1 abnormal pituitary gland morphology 0.0993417170566216 0.289528437232978 1.22880178511283 0.4375 7.1 7 1 abnormal meiosis 0.0993417170566216 0.289528437232978 1.22880178511283 0.4375 7.1 7 1 small pancreas 0.0993417170566216 0.289528437232978 1.22880178511283 0.4375 7.1 7 1 increased thymus weight 0.0993417170566216 0.289528437232978 1.22880178511283 0.4375 7.1 7 1 decreased circulating prolactin level 0.0993417170566216 0.289528437232978 1.22880178511283 0.4375 7.1 7 1 blepharitis 0.0993417170566216 0.289528437232978 1.22880178511283 0.4375 7.1 7 1 short limbs 0.000323124871578967 0.0042082362201711 1.22678404819147 0.436781609195402 7.1 7 1 abnormal ovary morphology 0.00111179062354786 0.0113809842636844 1.22632934691341 0.436619718309859 7.1 7 1 increased circulating free fatty acid level 0.00111179062354786 0.0113809842636844 1.22632934691341 0.436619718309859 7.1 7 1 increased or absent threshold for auditory brainstem response 1.20239664361827e-10 7.29502841707429e-09 1.22454987582178 0.43598615916955 7.1 7 1 small lens 0.014197070034297 0.0803531551998039 1.22430067967286 0.435897435897436 7.1 7 1 acanthosis 0.014197070034297 0.0803531551998039 1.22430067967286 0.435897435897436 7.1 7 1 increased vascular permeability 0.014197070034297 0.0803531551998039 1.22430067967286 0.435897435897436 7.1 7 1 abnormal sternum morphology 0.00143941403197202 0.0138774611911298 1.22116947588853 0.434782608695652 7.1 7 1 abnormal cell death 0.00845644922601089 0.0529192891816405 1.22116947588853 0.434782608695652 7.1 7 1 abnormal myelin sheath morphology 0.00845644922601089 0.0529192891816405 1.22116947588853 0.434782608695652 7.1 7 1 fragile skeleton 0.0553232183661354 0.209236034603959 1.22116947588853 0.434782608695652 7.1 7 1 abnormal carpal bone morphology 0.0553232183661354 0.209236034603959 1.22116947588853 0.434782608695652 7.1 7 1 conjunctivitis 0.0553232183661354 0.209236034603959 1.22116947588853 0.434782608695652 7.1 7 1 abnormal cardiovascular development 0.0553232183661354 0.209236034603959 1.22116947588853 0.434782608695652 7.1 7 1 abnormal crista ampullaris morphology 0.0553232183661354 0.209236034603959 1.22116947588853 0.434782608695652 7.1 7 1 abnormal B cell morphology 0.0553232183661354 0.209236034603959 1.22116947588853 0.434782608695652 7.1 7 1 abnormal ulna morphology 0.0553232183661354 0.209236034603959 1.22116947588853 0.434782608695652 7.1 7 1 abnormal palatal shelf fusion at midline 0.0553232183661354 0.209236034603959 1.22116947588853 0.434782608695652 7.1 7 1 abnormal hepatocyte physiology 0.0553232183661354 0.209236034603959 1.22116947588853 0.434782608695652 7.1 7 1 increased leukocyte cell number 5.40263082694725e-06 0.000123293983321388 1.22032729004309 0.43448275862069 7.1 7 1 oxidative stress 0.000330623042927671 0.00426126849369213 1.2170989109689 0.433333333333333 7.1 7 1 abnormal long bone epiphyseal plate morphology 0.00306816871034982 0.0250231792360498 1.2170989109689 0.433333333333333 7.1 7 1 delayed eyelid opening 0.0317823663050586 0.143352014839226 1.2170989109689 0.433333333333333 7.1 7 1 abnormal hepatocyte morphology 7.74648944271771e-05 0.00125533501555442 1.21456855980265 0.432432432432432 7.1 7 1 abnormal hair follicle development 0.0186061536171627 0.0911559463381162 1.21456855980265 0.432432432432432 7.1 7 1 abnormal respiratory electron transport chain 0.0186061536171627 0.0911559463381162 1.21456855980265 0.432432432432432 7.1 7 1 small kidney 0.000426018199376134 0.00522029690122233 1.21284332037111 0.431818181818182 7.1 7 1 increased T cell number 0.000426018199376134 0.00522029690122233 1.21284332037111 0.431818181818182 7.1 7 1 increased anxiety-related response 1.14062983396024e-05 0.000236443059331342 1.21238408397566 0.431654676258993 7.1 7 1 increased inflammatory response 0.00026189141115224 0.00352137775806052 1.21217138501356 0.431578947368421 7.1 7 1 abnormal seminiferous tubule morphology 7.08286999208306e-06 0.000153205557437449 1.2119688839469 0.431506849315068 7.1 7 1 impaired hematopoiesis 0.00660174804440708 0.0434440430170969 1.21159167607764 0.431372549019608 7.1 7 1 abnormal renal glomerulus morphology 9.95389451839213e-05 0.00154049483264675 1.21108642517018 0.431192660550459 7.1 7 1 abnormal forebrain development 0.0014667585453289 0.0139791642969565 1.20929699487295 0.430555555555556 7.1 7 1 increased T cell proliferation 0.000127849699175749 0.00192160801631225 1.20747411728043 0.429906542056075 7.1 7 1 abnormal lens morphology 3.02292377203698e-05 0.000574009380377251 1.20685889609296 0.4296875 7.1 7 1 abnormal rib morphology 1.8736897549643e-05 0.00036990502106934 1.20669635617429 0.42962962962963 7.1 7 1 increased circulating LDL cholesterol level 0.00858052336970503 0.0535609833930772 1.20372419766155 0.428571428571429 7.1 7 1 increased fluid intake 0.00858052336970503 0.0535609833930772 1.20372419766155 0.428571428571429 7.1 7 1 myoclonus 0.0419465291617374 0.175956140455011 1.20372419766155 0.428571428571429 7.1 7 1 abnormal somite shape 0.0419465291617374 0.175956140455011 1.20372419766155 0.428571428571429 7.1 7 1 absent corpus callosum 0.0419465291617374 0.175956140455011 1.20372419766155 0.428571428571429 7.1 7 1 corneal vascularization 0.0419465291617374 0.175956140455011 1.20372419766155 0.428571428571429 7.1 7 1 abnormal antigen presentation 0.135033637692016 0.357178404636869 1.20372419766155 0.428571428571429 7.1 7 1 abnormal endplate potential 0.135033637692016 0.357178404636869 1.20372419766155 0.428571428571429 7.1 7 1 abnormal prepulse inhibition 0.135033637692016 0.357178404636869 1.20372419766155 0.428571428571429 7.1 7 1 amyloid beta deposits 0.135033637692016 0.357178404636869 1.20372419766155 0.428571428571429 7.1 7 1 absent olfactory bulb 0.135033637692016 0.357178404636869 1.20372419766155 0.428571428571429 7.1 7 1 abnormal decidualization 0.135033637692016 0.357178404636869 1.20372419766155 0.428571428571429 7.1 7 1 abnormal pancreas development 0.135033637692016 0.357178404636869 1.20372419766155 0.428571428571429 7.1 7 1 lysosomal protein accumulation 0.135033637692016 0.357178404636869 1.20372419766155 0.428571428571429 7.1 7 1 increased lung compliance 0.135033637692016 0.357178404636869 1.20372419766155 0.428571428571429 7.1 7 1 decreased response to antigen 0.135033637692016 0.357178404636869 1.20372419766155 0.428571428571429 7.1 7 1 abnormal lung morphology 6.26006297110524e-05 0.00105321960733823 1.20372419766155 0.428571428571429 7.1 7 1 abnormal cartilage morphology 0.0143905410746289 0.0809379970264914 1.20372419766155 0.428571428571429 7.1 7 1 disheveled coat 0.0143905410746289 0.0809379970264914 1.20372419766155 0.428571428571429 7.1 7 1 abnormal dermal layer morphology 0.0243880662995205 0.114679234253416 1.20372419766155 0.428571428571429 7.1 7 1 abnormal intestinal goblet cell morphology 0.0243880662995205 0.114679234253416 1.20372419766155 0.428571428571429 7.1 7 1 abnormal scapula morphology 0.0737955489385071 0.231046479527421 1.20372419766155 0.428571428571429 7.1 7 1 abnormal hematopoietic system physiology 0.0737955489385071 0.231046479527421 1.20372419766155 0.428571428571429 7.1 7 1 abnormal associative learning 0.0737955489385071 0.231046479527421 1.20372419766155 0.428571428571429 7.1 7 1 abnormal embryonic/fetal subventricular zone morphology 0.0737955489385071 0.231046479527421 1.20372419766155 0.428571428571429 7.1 7 1 increased acute inflammation 0.0737955489385071 0.231046479527421 1.20372419766155 0.428571428571429 7.1 7 1 abnormal stapes morphology 0.0737955489385071 0.231046479527421 1.20372419766155 0.428571428571429 7.1 7 1 abnormal clavicle morphology 0.0737955489385071 0.231046479527421 1.20372419766155 0.428571428571429 7.1 7 1 decreased neutrophil cell number 8.02298203921409e-05 0.00127961288584982 1.200294783993 0.427350427350427 7.1 7 1 increased sensitivity to xenobiotic induced morbidity/mortality 0.000129894494338067 0.0019464611726864 1.20007654857773 0.427272727272727 7.1 7 1 abnormal enzyme/coenzyme activity 5.82991331321802e-06 0.00013123899879303 1.19861284225747 0.426751592356688 7.1 7 1 abnormal male meiosis 0.00402947733545532 0.0307794798695931 1.19714646980548 0.426229508196721 7.1 7 1 decreased platelet aggregation 0.00668034428923799 0.0438452675975712 1.19629380137969 0.425925925925926 7.1 7 1 belly spot 0.0319698285008255 0.143417400172774 1.19156536738214 0.424242424242424 7.1 7 1 abnormal epidermis stratum basale morphology 0.0319698285008255 0.143417400172774 1.19156536738214 0.424242424242424 7.1 7 1 abnormal skeleton physiology 0.0319698285008255 0.143417400172774 1.19156536738214 0.424242424242424 7.1 7 1 abnormal T cell subpopulation ratio 0.0319698285008255 0.143417400172774 1.19156536738214 0.424242424242424 7.1 7 1 abnormal thoracic vertebrae morphology 0.00520616584841944 0.0363773526627623 1.19012279429814 0.423728813559322 7.1 7 1 decreased litter size 3.22147943911759e-09 1.58681784253565e-07 1.18944514430851 0.423487544483986 7.1 7 1 absent corpus luteum 0.00865092823506299 0.0536802561801058 1.18829183615307 0.423076923076923 7.1 7 1 abnormal brain wave pattern 0.00865092823506299 0.0536802561801058 1.18829183615307 0.423076923076923 7.1 7 1 increased susceptibility to otitis media 0.0553979089616415 0.209236034603959 1.18829183615307 0.423076923076923 7.1 7 1 abnormal erythrocyte osmotic lysis 0.0553979089616415 0.209236034603959 1.18829183615307 0.423076923076923 7.1 7 1 weight loss 2.95030921646011e-06 7.23043761176799e-05 1.18767454169273 0.422857142857143 7.1 7 1 abnormal kidney morphology 2.95030921646011e-06 7.23043761176799e-05 1.18767454169273 0.422857142857143 7.1 7 1 altered response to myocardial infarction 0.0144798174806203 0.0809379970264914 1.18589124658508 0.422222222222222 7.1 7 1 abnormal autopod morphology 0.0144798174806203 0.0809379970264914 1.18589124658508 0.422222222222222 7.1 7 1 impaired righting response 0.000568177045119734 0.00636639819700603 1.18260622928152 0.421052631578947 7.1 7 1 flaky skin 0.0986283562734762 0.289143236570739 1.18260622928152 0.421052631578947 7.1 7 1 unresponsive to tactile stimuli 0.0986283562734762 0.289143236570739 1.18260622928152 0.421052631578947 7.1 7 1 delayed sexual maturation 0.0986283562734762 0.289143236570739 1.18260622928152 0.421052631578947 7.1 7 1 decreased germ cell number 0.0986283562734762 0.289143236570739 1.18260622928152 0.421052631578947 7.1 7 1 abnormal nasal septum morphology 0.0986283562734762 0.289143236570739 1.18260622928152 0.421052631578947 7.1 7 1 abnormal digestive system development 0.0986283562734762 0.289143236570739 1.18260622928152 0.421052631578947 7.1 7 1 abnormal cochlear inner hair cell morphology 0.0986283562734762 0.289143236570739 1.18260622928152 0.421052631578947 7.1 7 1 eyelids fail to open 0.0986283562734762 0.289143236570739 1.18260622928152 0.421052631578947 7.1 7 1 decreased liver regeneration 0.0986283562734762 0.289143236570739 1.18260622928152 0.421052631578947 7.1 7 1 abnormal suckling behavior 0.000925756287511622 0.00975132106543471 1.18092639088766 0.420454545454545 7.1 7 1 increased monocyte cell number 0.000446960966120472 0.00542895239865676 1.17964971370832 0.42 7.1 7 1 abnormal liver physiology 0.000446960966120472 0.00542895239865676 1.17964971370832 0.42 7.1 7 1 decreased circulating alkaline phosphatase level 0.011196674670434 0.0668708961409471 1.17964971370832 0.42 7.1 7 1 decreased neuronal precursor cell number 0.0419098007348991 0.175956140455011 1.17783765577636 0.419354838709677 7.1 7 1 decreased circulating calcium level 0.00867516099875479 0.0536802561801058 1.17454300499097 0.418181818181818 7.1 7 1 abnormal head morphology 0.00867516099875479 0.0536802561801058 1.17454300499097 0.418181818181818 7.1 7 1 abnormal contextual conditioning behavior 0.00867516099875479 0.0536802561801058 1.17454300499097 0.418181818181818 7.1 7 1 decreased compact bone thickness 0.00407560361080432 0.0310032537672041 1.17378080966002 0.417910447761194 7.1 7 1 hunched posture 0.00193810514866859 0.0170354648668308 1.173250167341 0.417721518987342 7.1 7 1 increased thermal nociceptive threshold 0.000929770027217345 0.0097586622054985 1.17285947464459 0.417582417582418 7.1 7 1 male infertility 2.27561032268504e-14 2.6328282221763e-12 1.17261402953113 0.417495029821074 7.1 7 1 abnormal kidney development 0.00673330666132628 0.0439032773788968 1.17028741439317 0.416666666666667 7.1 7 1 abnormal systemic arterial blood pressure 0.0318945583071422 0.143417400172774 1.17028741439317 0.416666666666667 7.1 7 1 abnormal trophoblast giant cell morphology 0.0318945583071422 0.143417400172774 1.17028741439317 0.416666666666667 7.1 7 1 decreased ovulation rate 0.0732095242446081 0.230908914990112 1.17028741439317 0.416666666666667 7.1 7 1 abnormal osteoblast morphology 0.0732095242446081 0.230908914990112 1.17028741439317 0.416666666666667 7.1 7 1 increased growth rate 0.184598097400074 0.42990057795103 1.17028741439317 0.416666666666667 7.1 7 1 abnormal corticospinal tract morphology 0.184598097400074 0.42990057795103 1.17028741439317 0.416666666666667 7.1 7 1 abnormal AMPA-mediated synaptic currents 0.184598097400074 0.42990057795103 1.17028741439317 0.416666666666667 7.1 7 1 abnormal alisphenoid bone morphology 0.184598097400074 0.42990057795103 1.17028741439317 0.416666666666667 7.1 7 1 dilated bile duct 0.184598097400074 0.42990057795103 1.17028741439317 0.416666666666667 7.1 7 1 decreased circulating ketone body level 0.184598097400074 0.42990057795103 1.17028741439317 0.416666666666667 7.1 7 1 abnormal vascular endothelial cell development 0.184598097400074 0.42990057795103 1.17028741439317 0.416666666666667 7.1 7 1 absent ovary 0.184598097400074 0.42990057795103 1.17028741439317 0.416666666666667 7.1 7 1 abnormal defecation 0.184598097400074 0.42990057795103 1.17028741439317 0.416666666666667 7.1 7 1 increased hepatocyte proliferation 0.184598097400074 0.42990057795103 1.17028741439317 0.416666666666667 7.1 7 1 absent cochlear hair cells 0.184598097400074 0.42990057795103 1.17028741439317 0.416666666666667 7.1 7 1 decreased cochlear nerve compound action potential 0.184598097400074 0.42990057795103 1.17028741439317 0.416666666666667 7.1 7 1 small parietal bone 0.184598097400074 0.42990057795103 1.17028741439317 0.416666666666667 7.1 7 1 abnormal amacrine cell morphology 0.184598097400074 0.42990057795103 1.17028741439317 0.416666666666667 7.1 7 1 abnormal palatine bone morphology 0.184598097400074 0.42990057795103 1.17028741439317 0.416666666666667 7.1 7 1 abnormal somatic nervous system physiology 0.184598097400074 0.42990057795103 1.17028741439317 0.416666666666667 7.1 7 1 decreased renal glomerular filtration rate 0.184598097400074 0.42990057795103 1.17028741439317 0.416666666666667 7.1 7 1 reduced cerebellar foliation 0.184598097400074 0.42990057795103 1.17028741439317 0.416666666666667 7.1 7 1 increased type II pneumocyte number 0.184598097400074 0.42990057795103 1.17028741439317 0.416666666666667 7.1 7 1 abnormal colon goblet cell morphology 0.184598097400074 0.42990057795103 1.17028741439317 0.416666666666667 7.1 7 1 scaly skin 0.024387222933074 0.114679234253416 1.16457869529857 0.414634146341463 7.1 7 1 abnormal neuron morphology 0.000730249206105548 0.00788067201816725 1.16319476339685 0.414141414141414 7.1 7 1 increased mean corpuscular hemoglobin 0.000730249206105548 0.00788067201816725 1.16319476339685 0.414141414141414 7.1 7 1 abnormal retinal pigmentation 0.0015170971492194 0.0142946180253153 1.1622164667077 0.413793103448276 7.1 7 1 dermatitis 0.00865988114733959 0.0536802561801058 1.1622164667077 0.413793103448276 7.1 7 1 abnormal middle ear morphology 0.0549364480969649 0.209236034603959 1.1622164667077 0.413793103448276 7.1 7 1 abnormal microglial cell morphology 0.0549364480969649 0.209236034603959 1.1622164667077 0.413793103448276 7.1 7 1 abnormal circulating glucose level 0.0549364480969649 0.209236034603959 1.1622164667077 0.413793103448276 7.1 7 1 absent long term depression 0.0549364480969649 0.209236034603959 1.1622164667077 0.413793103448276 7.1 7 1 abnormal outer ear morphology 0.0549364480969649 0.209236034603959 1.1622164667077 0.413793103448276 7.1 7 1 polychromatophilia 0.0549364480969649 0.209236034603959 1.1622164667077 0.413793103448276 7.1 7 1 abnormal spermatogenesis 6.201270824207e-06 0.000137729117635847 1.1601110020941 0.41304347826087 7.1 7 1 increased circulating aspartate transaminase level 0.00671668808069336 0.0438523926528208 1.15914181997038 0.412698412698413 7.1 7 1 abnormal blood homeostasis 0.000353313187592084 0.00453023996976964 1.15796859950482 0.412280701754386 7.1 7 1 decreased susceptibility to injury 0.00521826033921006 0.0364107225632119 1.15651932716502 0.411764705882353 7.1 7 1 abnormal cued conditioning behavior 0.0144131233086529 0.0809379970264914 1.15651932716502 0.411764705882353 7.1 7 1 abnormal cervical vertebrae morphology 0.0144131233086529 0.0809379970264914 1.15651932716502 0.411764705882353 7.1 7 1 abnormal retinal photoreceptor morphology 0.0415512850769608 0.175184443438881 1.15651932716502 0.411764705882353 7.1 7 1 lung hemorrhage 0.0415512850769608 0.175184443438881 1.15651932716502 0.411764705882353 7.1 7 1 abnormal nervous system development 0.0415512850769608 0.175184443438881 1.15651932716502 0.411764705882353 7.1 7 1 decreased osteoblast cell number 0.0415512850769608 0.175184443438881 1.15651932716502 0.411764705882353 7.1 7 1 increased incidence of corneal inflammation 0.132099346046316 0.35371057404759 1.15651932716502 0.411764705882353 7.1 7 1 abnormal duodenum morphology 0.132099346046316 0.35371057404759 1.15651932716502 0.411764705882353 7.1 7 1 abnormal testis development 0.132099346046316 0.35371057404759 1.15651932716502 0.411764705882353 7.1 7 1 increased regulatory T cell number 0.132099346046316 0.35371057404759 1.15651932716502 0.411764705882353 7.1 7 1 pancytopenia 0.132099346046316 0.35371057404759 1.15651932716502 0.411764705882353 7.1 7 1 increased circulating magnesium level 0.132099346046316 0.35371057404759 1.15651932716502 0.411764705882353 7.1 7 1 increased hepatoma incidence 0.132099346046316 0.35371057404759 1.15651932716502 0.411764705882353 7.1 7 1 common atrium 0.132099346046316 0.35371057404759 1.15651932716502 0.411764705882353 7.1 7 1 abnormal survival 0.132099346046316 0.35371057404759 1.15651932716502 0.411764705882353 7.1 7 1 astrocytosis 0.00406011570240339 0.0309327344861514 1.15425607994943 0.410958904109589 7.1 7 1 reduced long term potentiation 0.000448787445879894 0.00542895239865676 1.15356902275899 0.410714285714286 7.1 7 1 increased rib number 0.00316316355443808 0.0255881929810235 1.15228299263328 0.41025641025641 7.1 7 1 increased hepatocyte apoptosis 0.0316172019723275 0.142736460809736 1.15228299263328 0.41025641025641 7.1 7 1 decreased B-1 B cell number 0.0316172019723275 0.142736460809736 1.15228299263328 0.41025641025641 7.1 7 1 enlarged liver 0.00092711052541721 0.00975132106543471 1.15156281576288 0.41 7.1 7 1 increased double-negative T cell number 0.00861096591540334 0.0536802561801058 1.15110237481296 0.409836065573771 7.1 7 1 no abnormal phenotype detected 7.74795960880178e-43 1.28486996845963e-39 1.15099622127983 0.409798270893372 7.1 7 1 short femur 0.00192648697655557 0.016986969534285 1.14900946140421 0.409090909090909 7.1 7 1 osteoporosis 0.0241728167402806 0.113990296950612 1.14900946140421 0.409090909090909 7.1 7 1 abnormal myelopoiesis 0.0241728167402806 0.113990296950612 1.14900946140421 0.409090909090909 7.1 7 1 decreased blood urea nitrogen level 0.0241728167402806 0.113990296950612 1.14900946140421 0.409090909090909 7.1 7 1 abnormal long bone epiphysis morphology 0.0968034297385271 0.28786435322724 1.14900946140421 0.409090909090909 7.1 7 1 abnormal tail movements 0.0968034297385271 0.28786435322724 1.14900946140421 0.409090909090909 7.1 7 1 testis hypoplasia 0.0968034297385271 0.28786435322724 1.14900946140421 0.409090909090909 7.1 7 1 increased skin papilloma incidence 0.0968034297385271 0.28786435322724 1.14900946140421 0.409090909090909 7.1 7 1 increased coping response 0.0968034297385271 0.28786435322724 1.14900946140421 0.409090909090909 7.1 7 1 cleft upper lip 0.0968034297385271 0.28786435322724 1.14900946140421 0.409090909090909 7.1 7 1 decreased circulating estradiol level 0.0968034297385271 0.28786435322724 1.14900946140421 0.409090909090909 7.1 7 1 increased bone volume 0.0968034297385271 0.28786435322724 1.14900946140421 0.409090909090909 7.1 7 1 abnormal testis morphology 0.000446876717767121 0.00542895239865676 1.14789930733522 0.408695652173913 7.1 7 1 liver inflammation 0.000350780740121031 0.00450939065142669 1.14688166610531 0.408333333333333 7.1 7 1 organ of Corti degeneration 0.0185526315403131 0.0911559463381162 1.14640399777291 0.408163265306122 7.1 7 1 decreased circulating creatinine level 0.0185526315403131 0.0911559463381162 1.14640399777291 0.408163265306122 7.1 7 1 abnormal spleen morphology 2.00210815498614e-05 0.000392145199647875 1.14607457133676 0.408045977011494 7.1 7 1 abnormal axial skeleton morphology 0.00403381324120095 0.0307794798695931 1.14564978461648 0.407894736842105 7.1 7 1 increased neuron apoptosis 0.00314202845685079 0.0254586181967959 1.14428102740666 0.407407407407407 7.1 7 1 abnormal trigeminal ganglion morphology 0.0719969810818784 0.229018529975924 1.14428102740666 0.407407407407407 7.1 7 1 abnormal type II pneumocyte morphology 0.0719969810818784 0.229018529975924 1.14428102740666 0.407407407407407 7.1 7 1 cryptorchism 0.0719969810818784 0.229018529975924 1.14428102740666 0.407407407407407 7.1 7 1 increased spleen weight 0.000566260956897379 0.00635925115251572 1.14336044733634 0.407079646017699 7.1 7 1 small ovary 0.0019129647859429 0.0169488228526429 1.14199475162762 0.406593406593407 7.1 7 1 abnormal locomotor activation 0.0019129647859429 0.0169488228526429 1.14199475162762 0.406593406593407 7.1 7 1 scoliosis 0.0540974558983765 0.208308702085467 1.14103022903334 0.40625 7.1 7 1 pancreatic islet hyperplasia 0.0540974558983765 0.208308702085467 1.14103022903334 0.40625 7.1 7 1 female infertility 2.26201677976776e-07 7.30748927230168e-06 1.14037029252147 0.406015037593985 7.1 7 1 abnormal food intake 0.00661638361250419 0.0434828381403016 1.13975817749596 0.405797101449275 7.1 7 1 abnormal intestine morphology 0.00513878851287165 0.0359570644887995 1.13865802481498 0.405405405405405 7.1 7 1 decreased circulating chloride level 0.0409548342321284 0.173996840567753 1.13865802481498 0.405405405405405 7.1 7 1 decreased food intake 0.00399724587325987 0.0305943049530275 1.13769713196703 0.40506329113924 7.1 7 1 increased food intake 0.00311347689452159 0.0253097182193544 1.1368506311248 0.404761904761905 7.1 7 1 abnormal vibrissa morphology 0.0311849665968168 0.141944381353306 1.1368506311248 0.404761904761905 7.1 7 1 abnormal spleen white pulp morphology 0.0311849665968168 0.141944381353306 1.1368506311248 0.404761904761905 7.1 7 1 abnormal tibia morphology 0.0238551052944428 0.113135508903578 1.13542778928359 0.404255319148936 7.1 7 1 decreased body temperature 0.018316545777859 0.0911559463381162 1.13427857087338 0.403846153846154 7.1 7 1 rib fusion 0.00843223974297017 0.0529008735451155 1.13186006645788 0.402985074626866 7.1 7 1 maternal effect 0.00843223974297017 0.0529008735451155 1.13186006645788 0.402985074626866 7.1 7 1 azoospermia 8.08068563612662e-05 0.00128029971464108 1.13054180409303 0.40251572327044 7.1 7 1 abnormal liver morphology 3.10587359879738e-05 0.000585292467955189 1.12975231959296 0.402234636871508 7.1 7 1 decreased birth weight 0.00236984383368252 0.0201883100557714 1.12347591781745 0.4 7.1 7 1 decreased insulin secretion 0.00303789112103955 0.0248169266456022 1.12347591781745 0.4 7.1 7 1 circling 0.003898755561426 0.0298864544192517 1.12347591781745 0.4 7.1 7 1 abnormal posture 0.00501003444652118 0.0353044212060097 1.12347591781745 0.4 7.1 7 1 intracranial hemorrhage 0.0138913673367811 0.0795370104800254 1.12347591781745 0.4 7.1 7 1 kidney inflammation 0.0234566027868991 0.111351716474068 1.12347591781745 0.4 7.1 7 1 testicular atrophy 0.0234566027868991 0.111351716474068 1.12347591781745 0.4 7.1 7 1 abnormal female reproductive system morphology 0.0401834068350324 0.172189878556663 1.12347591781745 0.4 7.1 7 1 impaired ovarian folliculogenesis 0.0401834068350324 0.172189878556663 1.12347591781745 0.4 7.1 7 1 head bobbing 0.0401834068350324 0.172189878556663 1.12347591781745 0.4 7.1 7 1 perinatal lethality 0.0401834068350324 0.172189878556663 1.12347591781745 0.4 7.1 7 1 abnormal skin pigmentation 0.0401834068350324 0.172189878556663 1.12347591781745 0.4 7.1 7 1 abnormal pancreatic beta cell morphology 0.0401834068350324 0.172189878556663 1.12347591781745 0.4 7.1 7 1 increased circulating serum albumin level 0.0529934309285874 0.204532442877985 1.12347591781745 0.4 7.1 7 1 decreased bone mineralization 0.0529934309285874 0.204532442877985 1.12347591781745 0.4 7.1 7 1 salivary gland inflammation 0.0703725026249025 0.225581959122996 1.12347591781745 0.4 7.1 7 1 abnormal thyroid gland morphology 0.0943168425162045 0.281817592503374 1.12347591781745 0.4 7.1 7 1 spontaneous skin ulceration 0.0943168425162045 0.281817592503374 1.12347591781745 0.4 7.1 7 1 abnormal primitive streak morphology 0.0943168425162045 0.281817592503374 1.12347591781745 0.4 7.1 7 1 decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 0.0943168425162045 0.281817592503374 1.12347591781745 0.4 7.1 7 1 abnormal basioccipital bone morphology 0.128057774099814 0.35371057404759 1.12347591781745 0.4 7.1 7 1 abnormal circulating enzyme level 0.128057774099814 0.35371057404759 1.12347591781745 0.4 7.1 7 1 abnormal hearing physiology 0.128057774099814 0.35371057404759 1.12347591781745 0.4 7.1 7 1 abnormal fibula morphology 0.128057774099814 0.35371057404759 1.12347591781745 0.4 7.1 7 1 abnormal Peyer's patch T cell area morphology 0.128057774099814 0.35371057404759 1.12347591781745 0.4 7.1 7 1 decreased paired-pulse facilitation 0.128057774099814 0.35371057404759 1.12347591781745 0.4 7.1 7 1 abnormal hyoid bone morphology 0.128057774099814 0.35371057404759 1.12347591781745 0.4 7.1 7 1 decreased skin tensile strength 0.128057774099814 0.35371057404759 1.12347591781745 0.4 7.1 7 1 kidney atrophy 0.128057774099814 0.35371057404759 1.12347591781745 0.4 7.1 7 1 nuclear cataracts 0.128057774099814 0.35371057404759 1.12347591781745 0.4 7.1 7 1 interdigital webbing 0.177334757430074 0.424154047218566 1.12347591781745 0.4 7.1 7 1 decreased salivation 0.177334757430074 0.424154047218566 1.12347591781745 0.4 7.1 7 1 abnormal enteric neuron morphology 0.177334757430074 0.424154047218566 1.12347591781745 0.4 7.1 7 1 hyperpigmentation 0.177334757430074 0.424154047218566 1.12347591781745 0.4 7.1 7 1 abnormal seizure response to electrical stimulation 0.177334757430074 0.424154047218566 1.12347591781745 0.4 7.1 7 1 abnormal apical ectodermal ridge morphology 0.177334757430074 0.424154047218566 1.12347591781745 0.4 7.1 7 1 abnormal lymph node B cell domain morphology 0.177334757430074 0.424154047218566 1.12347591781745 0.4 7.1 7 1 arthritis 0.177334757430074 0.424154047218566 1.12347591781745 0.4 7.1 7 1 abnormal glial cell morphology 0.177334757430074 0.424154047218566 1.12347591781745 0.4 7.1 7 1 decreased aggression towards males 0.177334757430074 0.424154047218566 1.12347591781745 0.4 7.1 7 1 abnormal dendritic cell morphology 0.177334757430074 0.424154047218566 1.12347591781745 0.4 7.1 7 1 abnormal Muller cell morphology 0.177334757430074 0.424154047218566 1.12347591781745 0.4 7.1 7 1 liver vascular congestion 0.177334757430074 0.424154047218566 1.12347591781745 0.4 7.1 7 1 bicuspid aortic valve 0.177334757430074 0.424154047218566 1.12347591781745 0.4 7.1 7 1 abnormal platelet physiology 0.018024344170257 0.0911559463381162 1.12347591781745 0.4 7.1 7 1 decreased B cell number 1.45060841922821e-05 0.000292177201848597 1.1180221512261 0.398058252427184 7.1 7 1 abnormal hair follicle morphology 0.0136432503691891 0.0785592252161064 1.11455944227921 0.396825396825397 7.1 7 1 increased sensitivity to induced morbidity/mortality 4.70624566165731e-05 0.00084319073564735 1.11431714674828 0.396739130434783 7.1 7 1 cochlear ganglion degeneration 0.0176877467661649 0.0911559463381162 1.11379078059488 0.396551724137931 7.1 7 1 thrombocytosis 0.0176877467661649 0.0911559463381162 1.11379078059488 0.396551724137931 7.1 7 1 curly tail 0.0299958541824977 0.137538594062604 1.11177304367352 0.395833333333333 7.1 7 1 increased total body fat amount 0.000520732083593312 0.00599718822286144 1.1108996948568 0.395522388059701 7.1 7 1 increased bone marrow cell number 0.0517054992679263 0.200807852348114 1.10869333995143 0.394736842105263 7.1 7 1 impaired swimming 0.0133698710070538 0.0773207314959069 1.10645355542627 0.393939393939394 7.1 7 1 dextrocardia 0.0684804137067848 0.221245386369256 1.10645355542627 0.393939393939394 7.1 7 1 cardiovascular system phenotype 0.0684804137067848 0.221245386369256 1.10645355542627 0.393939393939394 7.1 7 1 myeloid hyperplasia 0.0684804137067848 0.221245386369256 1.10645355542627 0.393939393939394 7.1 7 1 abnormal neuron differentiation 0.00173196795202408 0.0158101661675593 1.10341384785642 0.392857142857143 7.1 7 1 rib bifurcation 0.0914413911478517 0.278069022592031 1.10341384785642 0.392857142857143 7.1 7 1 abnormal respiration 0.0914413911478517 0.278069022592031 1.10341384785642 0.392857142857143 7.1 7 1 arrest of spermatogenesis 0.00610804868717941 0.0404089657163797 1.10341384785642 0.392857142857143 7.1 7 1 abnormal response to novel object 0.0292911056760904 0.134431043116743 1.1014469782524 0.392156862745098 7.1 7 1 decreased IgM level 0.00363128232321845 0.0286301577781486 1.10031146590369 0.391752577319588 7.1 7 1 increased lymphocyte cell number 0.0130767207915363 0.0757353736180363 1.09905252829968 0.391304347826087 7.1 7 1 abnormal nasal cavity morphology 0.123469279906493 0.344315957138341 1.09905252829968 0.391304347826087 7.1 7 1 abnormal corneal stroma morphology 0.123469279906493 0.344315957138341 1.09905252829968 0.391304347826087 7.1 7 1 liver fibrosis 0.0502929645322858 0.19578051529587 1.09607406616336 0.390243902439024 7.1 7 1 short humerus 0.0502929645322858 0.19578051529587 1.09607406616336 0.390243902439024 7.1 7 1 short ulna 0.0502929645322858 0.19578051529587 1.09607406616336 0.390243902439024 7.1 7 1 decreased anxiety-related response 0.00130293490749967 0.012785209398049 1.09607406616336 0.390243902439024 7.1 7 1 increased circulating glucose level 0.000616161510726195 0.00672237613127811 1.09558821772978 0.390070921985816 7.1 7 1 abnormal colon morphology 0.0219424935742208 0.105676578443125 1.09491297075429 0.389830508474576 7.1 7 1 diluted coat color 0.0285388610442977 0.131342121827365 1.09226825343363 0.388888888888889 7.1 7 1 impaired wound healing 0.0664199862331436 0.221245386369256 1.09226825343363 0.388888888888889 7.1 7 1 short radius 0.0664199862331436 0.221245386369256 1.09226825343363 0.388888888888889 7.1 7 1 head tilt 0.0664199862331436 0.221245386369256 1.09226825343363 0.388888888888889 7.1 7 1 abnormal retinal blood vessel morphology 0.0664199862331436 0.221245386369256 1.09226825343363 0.388888888888889 7.1 7 1 underdeveloped hair follicles 0.169436475355818 0.412211272243401 1.09226825343363 0.388888888888889 7.1 7 1 abnormal mammary gland morphology 0.169436475355818 0.412211272243401 1.09226825343363 0.388888888888889 7.1 7 1 abnormal Peyer's patch follicle morphology 0.169436475355818 0.412211272243401 1.09226825343363 0.388888888888889 7.1 7 1 absent allantois 0.169436475355818 0.412211272243401 1.09226825343363 0.388888888888889 7.1 7 1 abnormal redox activity 0.169436475355818 0.412211272243401 1.09226825343363 0.388888888888889 7.1 7 1 abnormal anterior eye segment morphology 0.169436475355818 0.412211272243401 1.09226825343363 0.388888888888889 7.1 7 1 decreased lactate dehydrogenase level 0.169436475355818 0.412211272243401 1.09226825343363 0.388888888888889 7.1 7 1 decreased fluid intake 0.169436475355818 0.412211272243401 1.09226825343363 0.388888888888889 7.1 7 1 increased body weight 2.44638652889854e-05 0.000471735386870939 1.09087505413078 0.388392857142857 7.1 7 1 decreased urine osmolality 0.0372432285225479 0.161398137543271 1.08908379788426 0.387755102040816 7.1 7 1 abnormal eyelid morphology 0.088348945923852 0.269323533070566 1.08723475917817 0.387096774193548 7.1 7 1 abnormal nose morphology 0.088348945923852 0.269323533070566 1.08723475917817 0.387096774193548 7.1 7 1 abnormal CD8-positive, alpha beta T cell morphology 0.088348945923852 0.269323533070566 1.08723475917817 0.387096774193548 7.1 7 1 abnormal circadian rhythm 0.0487996495049812 0.191191208908398 1.08517560243731 0.386363636363636 7.1 7 1 decreased sensitivity to induced morbidity/mortality 0.0487996495049812 0.191191208908398 1.08517560243731 0.386363636363636 7.1 7 1 dehydration 0.0160692139949385 0.0868960213313253 1.0833517778954 0.385714285714286 7.1 7 1 abnormal lipid level 0.00941745421285519 0.057984943946726 1.08286835452284 0.385542168674699 7.1 7 1 abnormal vertebrae morphology 0.00331348948478318 0.0267607308227213 1.0822474437691 0.385321100917431 7.1 7 1 abnormal excitatory postsynaptic currents 0.0121216127180949 0.0720490122730251 1.0802653055937 0.384615384615385 7.1 7 1 abnormal female meiosis 0.036150205612485 0.156797971161389 1.0802653055937 0.384615384615385 7.1 7 1 abnormal xiphoid process morphology 0.118641175987807 0.331409236686882 1.0802653055937 0.384615384615385 7.1 7 1 thick skin 0.118641175987807 0.331409236686882 1.0802653055937 0.384615384615385 7.1 7 1 abnormal tectorial membrane morphology 0.118641175987807 0.331409236686882 1.0802653055937 0.384615384615385 7.1 7 1 pulmonary edema 0.118641175987807 0.331409236686882 1.0802653055937 0.384615384615385 7.1 7 1 decreased bone resorption 0.118641175987807 0.331409236686882 1.0802653055937 0.384615384615385 7.1 7 1 abnormal nerve conduction 0.118641175987807 0.331409236686882 1.0802653055937 0.384615384615385 7.1 7 1 abnormal mast cell morphology 0.238620943376597 0.485224171660348 1.0802653055937 0.384615384615385 7.1 7 1 abnormal renal/urinary system morphology 0.238620943376597 0.485224171660348 1.0802653055937 0.384615384615385 7.1 7 1 pup cannibalization 0.238620943376597 0.485224171660348 1.0802653055937 0.384615384615385 7.1 7 1 abnormal digestion 0.238620943376597 0.485224171660348 1.0802653055937 0.384615384615385 7.1 7 1 abnormal pulmonary alveolus epithelial cell morphology 0.238620943376597 0.485224171660348 1.0802653055937 0.384615384615385 7.1 7 1 abnormal intercostal muscle morphology 0.238620943376597 0.485224171660348 1.0802653055937 0.384615384615385 7.1 7 1 decreased endocochlear potential 0.238620943376597 0.485224171660348 1.0802653055937 0.384615384615385 7.1 7 1 abnormal exocrine pancreas morphology 0.238620943376597 0.485224171660348 1.0802653055937 0.384615384615385 7.1 7 1 small pituitary gland 0.238620943376597 0.485224171660348 1.0802653055937 0.384615384615385 7.1 7 1 orthokeratosis 0.238620943376597 0.485224171660348 1.0802653055937 0.384615384615385 7.1 7 1 empty decidua capsularis 0.238620943376597 0.485224171660348 1.0802653055937 0.384615384615385 7.1 7 1 deafness 0.00542516307520406 0.0374695727491016 1.07808295144098 0.383838383838384 7.1 7 1 increased systemic arterial blood pressure 0.0472582046397722 0.187937304622595 1.07566843195287 0.382978723404255 7.1 7 1 abnormal T-helper 1 physiology 0.0472582046397722 0.187937304622595 1.07566843195287 0.382978723404255 7.1 7 1 increased respiratory quotient 0.0472582046397722 0.187937304622595 1.07566843195287 0.382978723404255 7.1 7 1 abnormal oocyte morphology 0.0851508266681042 0.260052401886936 1.07391080379609 0.382352941176471 7.1 7 1 abnormal bone remodeling 0.0851508266681042 0.260052401886936 1.07391080379609 0.382352941176471 7.1 7 1 abnormal direction of heart looping 0.0851508266681042 0.260052401886936 1.07391080379609 0.382352941176471 7.1 7 1 decreased regulatory T cell number 0.0851508266681042 0.260052401886936 1.07391080379609 0.382352941176471 7.1 7 1 decreased rib number 0.00891794524519853 0.0551048358114841 1.07298261814026 0.382022471910112 7.1 7 1 abnormal learning/memory/conditioning 0.0350331214664992 0.153154463353105 1.07240883064393 0.381818181818182 7.1 7 1 abnormal T-helper 2 physiology 0.0350331214664992 0.153154463353105 1.07240883064393 0.381818181818182 7.1 7 1 small ears 0.161449912660619 0.412211272243401 1.06997706458804 0.380952380952381 7.1 7 1 abnormal eye pigmentation 0.161449912660619 0.412211272243401 1.06997706458804 0.380952380952381 7.1 7 1 abnormal tumor vascularization 0.161449912660619 0.412211272243401 1.06997706458804 0.380952380952381 7.1 7 1 vascular ring 0.161449912660619 0.412211272243401 1.06997706458804 0.380952380952381 7.1 7 1 decreased oocyte number 0.0456930959089132 0.182149961656124 1.06730212192657 0.38 7.1 7 1 abnormal spermiogenesis 0.0339051080944284 0.14861490111875 1.06536509448206 0.379310344827586 7.1 7 1 focal hair loss 0.113749967456727 0.328447938142791 1.06536509448206 0.379310344827586 7.1 7 1 short sternum 0.113749967456727 0.328447938142791 1.06536509448206 0.379310344827586 7.1 7 1 alopecia 0.00841366281307274 0.0529008735451155 1.06434560635337 0.378947368421053 7.1 7 1 abnormal skin morphology 0.0253058673570928 0.117770523949052 1.06389764944834 0.378787878787879 7.1 7 1 increased white adipose tissue amount 0.0819205135381092 0.25337257557172 1.06274748982731 0.378378378378378 7.1 7 1 sparse hair 0.014282061298187 0.0807423351800914 1.06182175159576 0.378048780487805 7.1 7 1 abnormal cartilage development 0.0598282982689253 0.211396153329477 1.06106058904981 0.377777777777778 7.1 7 1 abnormal metabolism 0.0598282982689253 0.211396153329477 1.06106058904981 0.377777777777778 7.1 7 1 abnormal pancreatic islet morphology 0.0441227151487092 0.178074615792573 1.05988294133721 0.377358490566038 7.1 7 1 hyperkeratosis 0.0244843164903521 0.115023110991031 1.05834687910339 0.376811594202899 7.1 7 1 abnormal definitive hematopoiesis 0.0104504545542653 0.0630923121153585 1.05703379364545 0.376344086021505 7.1 7 1 abnormal T cell differentiation 0.00791387535458727 0.0500273569111457 1.05673477418473 0.376237623762376 7.1 7 1 lung inflammation 0.0025731174245309 0.0215509413923253 1.05325867295386 0.375 7.1 7 1 short mandible 0.0425608952394248 0.177933484727832 1.05325867295386 0.375 7.1 7 1 abnormal seminal vesicle morphology 0.0425608952394248 0.177933484727832 1.05325867295386 0.375 7.1 7 1 abnormal lymph node morphology 0.0576156149141372 0.209989690908866 1.05325867295386 0.375 7.1 7 1 increased circulating follicle stimulating hormone level 0.108899839939138 0.316089092005373 1.05325867295386 0.375 7.1 7 1 increased dopamine level 0.108899839939138 0.316089092005373 1.05325867295386 0.375 7.1 7 1 increased stereotypic behavior 0.153625133303624 0.400778730039606 1.05325867295386 0.375 7.1 7 1 abnormal startle reflex 0.153625133303624 0.400778730039606 1.05325867295386 0.375 7.1 7 1 small lymph nodes 0.153625133303624 0.400778730039606 1.05325867295386 0.375 7.1 7 1 abnormal primitive streak formation 0.153625133303624 0.400778730039606 1.05325867295386 0.375 7.1 7 1 abnormal tumor morphology 0.153625133303624 0.400778730039606 1.05325867295386 0.375 7.1 7 1 decreased fatty acid level 0.153625133303624 0.400778730039606 1.05325867295386 0.375 7.1 7 1 abnormal cellular extravasation 0.153625133303624 0.400778730039606 1.05325867295386 0.375 7.1 7 1 failure of tooth eruption 0.224130581654146 0.485224171660348 1.05325867295386 0.375 7.1 7 1 abnormal mouth morphology 0.224130581654146 0.485224171660348 1.05325867295386 0.375 7.1 7 1 abnormal intestinal absorption 0.224130581654146 0.485224171660348 1.05325867295386 0.375 7.1 7 1 abnormal extraembryonic endoderm formation 0.224130581654146 0.485224171660348 1.05325867295386 0.375 7.1 7 1 intraventricular hemorrhage 0.224130581654146 0.485224171660348 1.05325867295386 0.375 7.1 7 1 white spotting 0.224130581654146 0.485224171660348 1.05325867295386 0.375 7.1 7 1 decreased cochlear coiling 0.224130581654146 0.485224171660348 1.05325867295386 0.375 7.1 7 1 abnormal pulmonary elastic fiber morphology 0.224130581654146 0.485224171660348 1.05325867295386 0.375 7.1 7 1 large intestinal inflammation 0.224130581654146 0.485224171660348 1.05325867295386 0.375 7.1 7 1 decreased circulating growth hormone level 0.224130581654146 0.485224171660348 1.05325867295386 0.375 7.1 7 1 decreased circulating triiodothyronine level 0.224130581654146 0.485224171660348 1.05325867295386 0.375 7.1 7 1 dilated respiratory conducting tubes 0.224130581654146 0.485224171660348 1.05325867295386 0.375 7.1 7 1 decreased white adipose tissue amount 0.0305468289930603 0.139294660165421 1.04801858005359 0.373134328358209 7.1 7 1 distended abdomen 0.0554317776096519 0.209236034603959 1.04637462933978 0.372549019607843 7.1 7 1 increased lung adenocarcinoma incidence 0.0554317776096519 0.209236034603959 1.04637462933978 0.372549019607843 7.1 7 1 abnormal thrombosis 0.0554317776096519 0.209236034603959 1.04637462933978 0.372549019607843 7.1 7 1 abnormal male reproductive system morphology 0.0755432854683861 0.236072767088707 1.04509387703949 0.372093023255814 7.1 7 1 abnormal axon guidance 0.0755432854683861 0.236072767088707 1.04509387703949 0.372093023255814 7.1 7 1 increased bone mineral density 0.00695211988582518 0.0452706759580893 1.04393779974188 0.371681415929204 7.1 7 1 decreased T cell proliferation 0.00226862302208778 0.0194258167553988 1.0437698560804 0.371621621621622 7.1 7 1 decreased tumor growth/size 0.0532896881513041 0.205516432986618 1.0402554794606 0.37037037037037 7.1 7 1 decreased susceptibility to pharmacologically induced seizures 0.146078937697176 0.383303119748655 1.0402554794606 0.37037037037037 7.1 7 1 decreased bone ossification 0.146078937697176 0.383303119748655 1.0402554794606 0.37037037037037 7.1 7 1 seminiferous tubule degeneration 0.0283886610924915 0.130771841606616 1.03883047195449 0.36986301369863 7.1 7 1 delayed wound healing 0.0724510812545189 0.230315737534333 1.03799405450525 0.369565217391304 7.1 7 1 abnormal circulating amino acid level 0.0511984286092825 0.199020168661436 1.03478045062133 0.368421052631579 7.1 7 1 hyporesponsive to tactile stimuli 0.0995459385290493 0.289953772940293 1.03478045062133 0.368421052631579 7.1 7 1 small superior vagus ganglion 0.210741211487184 0.470784700111692 1.03478045062133 0.368421052631579 7.1 7 1 thin dermal layer 0.210741211487184 0.470784700111692 1.03478045062133 0.368421052631579 7.1 7 1 decreased grooming behavior 0.210741211487184 0.470784700111692 1.03478045062133 0.368421052631579 7.1 7 1 decreased tumor incidence 0.210741211487184 0.470784700111692 1.03478045062133 0.368421052631579 7.1 7 1 abnormal neurotransmitter level 0.210741211487184 0.470784700111692 1.03478045062133 0.368421052631579 7.1 7 1 osteoarthritis 0.210741211487184 0.470784700111692 1.03478045062133 0.368421052631579 7.1 7 1 abnormal sternebra morphology 0.210741211487184 0.470784700111692 1.03478045062133 0.368421052631579 7.1 7 1 abnormal behavioral response to xenobiotic 0.210741211487184 0.470784700111692 1.03478045062133 0.368421052631579 7.1 7 1 increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 0.210741211487184 0.470784700111692 1.03478045062133 0.368421052631579 7.1 7 1 decreased liver glycogen level 0.210741211487184 0.470784700111692 1.03478045062133 0.368421052631579 7.1 7 1 shortened RR interval 0.210741211487184 0.470784700111692 1.03478045062133 0.368421052631579 7.1 7 1 emphysema 0.138863236569888 0.364754277684897 1.02985292466599 0.366666666666667 7.1 7 1 enhanced paired-pulse facilitation 0.138863236569888 0.364754277684897 1.02985292466599 0.366666666666667 7.1 7 1 abnormal response/metabolism to endogenous compounds 0.0253380075690941 0.117809895005835 1.02756943702815 0.365853658536585 7.1 7 1 abnormal skin condition 0.0665332887595357 0.221245386369256 1.02625204031401 0.365384615384615 7.1 7 1 retinal degeneration 0.0176807693054515 0.0911559463381162 1.02400148759403 0.364583333333333 7.1 7 1 abnormal dendritic cell physiology 0.012880374679115 0.0746851562104861 1.02372805595515 0.364485981308411 7.1 7 1 abnormal CNS synaptic transmission 0.0170184373254936 0.0911559463381162 1.02134174347041 0.363636363636364 7.1 7 1 teratozoospermia 0.023445819522032 0.111351716474068 1.02134174347041 0.363636363636364 7.1 7 1 intracerebral hemorrhage 0.198390760044671 0.446401642343845 1.02134174347041 0.363636363636364 7.1 7 1 abnormal chorion morphology 0.198390760044671 0.446401642343845 1.02134174347041 0.363636363636364 7.1 7 1 parakeratosis 0.198390760044671 0.446401642343845 1.02134174347041 0.363636363636364 7.1 7 1 abnormal female reproductive system physiology 0.198390760044671 0.446401642343845 1.02134174347041 0.363636363636364 7.1 7 1 abnormal retinal layer morphology 0.198390760044671 0.446401642343845 1.02134174347041 0.363636363636364 7.1 7 1 failure of palatal shelf elevation 0.198390760044671 0.446401642343845 1.02134174347041 0.363636363636364 7.1 7 1 rough coat 0.198390760044671 0.446401642343845 1.02134174347041 0.363636363636364 7.1 7 1 abnormal B cell differentiation 0.0225439874814918 0.108363611324079 1.01853585955977 0.362637362637363 7.1 7 1 cochlear outer hair cell degeneration 0.0416593591517961 0.175491373226237 1.01424909247408 0.361111111111111 7.1 7 1 abnormal lysosome morphology 0.125480236886469 0.349727831098142 1.01424909247408 0.361111111111111 7.1 7 1 increased body length 0.0828050437017832 0.253510826102382 1.0111283260357 0.36 7.1 7 1 increased pre-B cell number 0.186986046871547 0.42990057795103 1.0111283260357 0.36 7.1 7 1 increased cellular sensitivity to ionizing radiation 0.186986046871547 0.42990057795103 1.0111283260357 0.36 7.1 7 1 impaired macrophage chemotaxis 0.119305680461818 0.333078428898735 1.00824761855412 0.358974358974359 7.1 7 1 abnormal stria vascularis morphology 0.176433130224578 0.424154047218566 1.00310349805129 0.357142857142857 7.1 7 1 shortened head 0.176433130224578 0.424154047218566 1.00310349805129 0.357142857142857 7.1 7 1 reddish skin 0.176433130224578 0.424154047218566 1.00310349805129 0.357142857142857 7.1 7 1 abnormal retinal inner nuclear layer morphology 0.176433130224578 0.424154047218566 1.00310349805129 0.357142857142857 7.1 7 1 abnormal renal tubule epithelium morphology 0.176433130224578 0.424154047218566 1.00310349805129 0.357142857142857 7.1 7 1 extended life span 0.296169446534698 0.508259053642677 1.00310349805129 0.357142857142857 7.1 7 1 abnormal spleen periarteriolar lymphoid sheath morphology 0.296169446534698 0.508259053642677 1.00310349805129 0.357142857142857 7.1 7 1 abnormal imprinting 0.296169446534698 0.508259053642677 1.00310349805129 0.357142857142857 7.1 7 1 abnormal sagittal suture morphology 0.296169446534698 0.508259053642677 1.00310349805129 0.357142857142857 7.1 7 1 enlarged stomach 0.296169446534698 0.508259053642677 1.00310349805129 0.357142857142857 7.1 7 1 abnormal maternal decidual layer morphology 0.296169446534698 0.508259053642677 1.00310349805129 0.357142857142857 7.1 7 1 abnormal squamosal bone morphology 0.296169446534698 0.508259053642677 1.00310349805129 0.357142857142857 7.1 7 1 abnormal positive T cell selection 0.296169446534698 0.508259053642677 1.00310349805129 0.357142857142857 7.1 7 1 abnormal glucose tolerance 0.296169446534698 0.508259053642677 1.00310349805129 0.357142857142857 7.1 7 1 spina bifida occulta 0.296169446534698 0.508259053642677 1.00310349805129 0.357142857142857 7.1 7 1 pulmonary alveolar hemorrhage 0.296169446534698 0.508259053642677 1.00310349805129 0.357142857142857 7.1 7 1 abnormal renal tubule epithelial cell primary cilium morphology 0.296169446534698 0.508259053642677 1.00310349805129 0.357142857142857 7.1 7 1 impaired fertilization 0.0512051891229424 0.199020168661436 1.00310349805129 0.357142857142857 7.1 7 1 hydroencephaly 0.0163660401442745 0.0884050485534913 1.00135897022859 0.356521739130435 7.1 7 1 decreased osteoclast cell number 0.107927192068152 0.313815184417918 0.998645260282175 0.355555555555556 7.1 7 1 absent mature ovarian follicles 0.166646096425209 0.412211272243401 0.996631862579993 0.354838709677419 7.1 7 1 increased lung adenoma incidence 0.166646096425209 0.412211272243401 0.996631862579993 0.354838709677419 7.1 7 1 abnormal T cell proliferation 0.166646096425209 0.412211272243401 0.996631862579993 0.354838709677419 7.1 7 1 abnormal response to infection 0.0448691050864207 0.179008659025616 0.995484990471155 0.354430379746835 7.1 7 1 abnormal intestinal epithelium morphology 0.102691377116055 0.298765848627119 0.994744302234198 0.354166666666667 7.1 7 1 abnormal kidney physiology 0.102691377116055 0.298765848627119 0.994744302234198 0.354166666666667 7.1 7 1 decreased monocyte cell number 0.0657030492268555 0.221245386369256 0.993844081146203 0.353846153846154 7.1 7 1 abnormal vision 0.157548924889571 0.410369581845873 0.991302280427159 0.352941176470588 7.1 7 1 increased susceptibility to weight gain 0.157548924889571 0.410369581845873 0.991302280427159 0.352941176470588 7.1 7 1 abnormal urinary bladder morphology 0.274329437440234 0.488139261555219 0.991302280427159 0.352941176470588 7.1 7 1 distended urinary bladder 0.274329437440234 0.488139261555219 0.991302280427159 0.352941176470588 7.1 7 1 abnormal touch/ nociception 0.274329437440234 0.488139261555219 0.991302280427159 0.352941176470588 7.1 7 1 aminoaciduria 0.274329437440234 0.488139261555219 0.991302280427159 0.352941176470588 7.1 7 1 decreased growth hormone level 0.274329437440234 0.488139261555219 0.991302280427159 0.352941176470588 7.1 7 1 increased kidney weight 0.0977359161156731 0.289143236570739 0.991302280427159 0.352941176470588 7.1 7 1 cochlear inner hair cell degeneration 0.0977359161156731 0.289143236570739 0.991302280427159 0.352941176470588 7.1 7 1 abnormal chromosome morphology 0.149075087033497 0.390341346311395 0.986836954839649 0.351351351351351 7.1 7 1 skin inflammation 0.149075087033497 0.390341346311395 0.986836954839649 0.351351351351351 7.1 7 1 obese 0.0546749027410992 0.209236034603959 0.984865252632178 0.350649350649351 7.1 7 1 increased B cell number 0.0220217950248449 0.105955928673698 0.984241722874259 0.35042735042735 7.1 7 1 abnormal social investigation 0.052233815739525 0.202701430034428 0.983041428090266 0.35 7.1 7 1 abnormal vascular regression 0.255263062388074 0.485224171660348 0.983041428090266 0.35 7.1 7 1 brain inflammation 0.255263062388074 0.485224171660348 0.983041428090266 0.35 7.1 7 1 abnormal lens epithelium morphology 0.255263062388074 0.485224171660348 0.983041428090266 0.35 7.1 7 1 abnormal male reproductive system physiology 0.255263062388074 0.485224171660348 0.983041428090266 0.35 7.1 7 1 dilated vasculature 0.255263062388074 0.485224171660348 0.983041428090266 0.35 7.1 7 1 abnormal response to tactile stimuli 0.255263062388074 0.485224171660348 0.983041428090266 0.35 7.1 7 1 abnormal induced retinal neovascularization 0.255263062388074 0.485224171660348 0.983041428090266 0.35 7.1 7 1 abnormal neuron proliferation 0.255263062388074 0.485224171660348 0.983041428090266 0.35 7.1 7 1 skin lesions 0.0804063866782704 0.251112224560198 0.980812309205708 0.349206349206349 7.1 7 1 abnormal epidermal layer morphology 0.0730405909715811 0.230908914990112 0.976935580710824 0.347826086956522 7.1 7 1 abnormal coat appearance 0.0730405909715811 0.230908914990112 0.976935580710824 0.347826086956522 7.1 7 1 abnormal sacral vertebrae morphology 0.238348882785033 0.485224171660348 0.976935580710824 0.347826086956522 7.1 7 1 decreased epididymis weight 0.238348882785033 0.485224171660348 0.976935580710824 0.347826086956522 7.1 7 1 abnormal lens development 0.238348882785033 0.485224171660348 0.976935580710824 0.347826086956522 7.1 7 1 infertility 0.0347975911268783 0.152392619591743 0.971229181290783 0.345794392523364 7.1 7 1 increased circulating calcium level 0.108520608242586 0.315356323602141 0.970274656296886 0.345454545454545 7.1 7 1 decreased exploration in new environment 0.0576676729980771 0.209989690908866 0.969666714782916 0.345238095238095 7.1 7 1 decreased retinal photoreceptor cell number 0.209424268523447 0.470165043278046 0.96851372225642 0.344827586206897 7.1 7 1 stomach inflammation 0.209424268523447 0.470165043278046 0.96851372225642 0.344827586206897 7.1 7 1 increased susceptibility to pharmacologically induced seizures 0.0478993115093928 0.190334724248586 0.965487116874369 0.34375 7.1 7 1 abnormal serotonin level 0.19689413553696 0.444441163473856 0.965487116874369 0.34375 7.1 7 1 abnormal auditory brainstem response waveform shape 0.19689413553696 0.444441163473856 0.965487116874369 0.34375 7.1 7 1 abnormal femur morphology 0.0887111196113684 0.270261984119141 0.964177093649301 0.343283582089552 7.1 7 1 decreased circulating thyroxine level 0.185407707883845 0.42990057795103 0.96297935812924 0.342857142857143 7.1 7 1 impaired behavioral response to xenobiotic 0.185407707883845 0.42990057795103 0.96297935812924 0.342857142857143 7.1 7 1 decreased IgG level 0.0381188203131587 0.165048852095705 0.961533443177094 0.342342342342342 7.1 7 1 increased grooming behavior 0.17483024425581 0.42201866335403 0.960867561291238 0.342105263157895 7.1 7 1 abnormal retinal outer nuclear layer morphology 0.17483024425581 0.42201866335403 0.960867561291238 0.342105263157895 7.1 7 1 abnormal excitatory postsynaptic potential 0.0695070379101435 0.222951330498365 0.959064807892943 0.341463414634146 7.1 7 1 abnormal cholesterol homeostasis 0.165052909952219 0.412211272243401 0.959064807892943 0.341463414634146 7.1 7 1 hepatic necrosis 0.14755526312534 0.386768932586179 0.956149717291444 0.340425531914894 7.1 7 1 decreased bone trabecula number 0.14755526312534 0.386768932586179 0.956149717291444 0.340425531914894 7.1 7 1 abnormal coat/ hair morphology 0.132356839027276 0.35420939976369 0.953894647203493 0.339622641509434 7.1 7 1 abnormal CD4-positive, alpha-beta T cell physiology 0.0969482590232211 0.28812281280796 0.949416268578124 0.338028169014085 7.1 7 1 increased circulating HDL cholesterol level 0.0643481982324741 0.221245386369256 0.936229931514539 0.333333333333333 7.1 7 1 abnormal urine homeostasis 0.074308648497203 0.232506620297852 0.936229931514539 0.333333333333333 7.1 7 1 abnormal nervous system electrophysiology 0.0903938819332598 0.275220050561792 0.936229931514539 0.333333333333333 7.1 7 1 epidermal hyperplasia 0.136378728119742 0.358606856445939 0.936229931514539 0.333333333333333 7.1 7 1 abnormal cytotoxic T cell physiology 0.190849450215642 0.431776268677952 0.936229931514539 0.333333333333333 7.1 7 1 abnormal response to injury 0.202592526152807 0.455650007961218 0.936229931514539 0.333333333333333 7.1 7 1 abnormal hair cycle 0.244704784500227 0.485224171660348 0.936229931514539 0.333333333333333 7.1 7 1 abnormal pain threshold 0.244704784500227 0.485224171660348 0.936229931514539 0.333333333333333 7.1 7 1 abnormal single cell response 0.261713469513467 0.485224171660348 0.936229931514539 0.333333333333333 7.1 7 1 abnormal synaptic transmission 0.244704784500227 0.485224171660348 0.936229931514539 0.333333333333333 7.1 7 1 curly vibrissae 0.280710757525738 0.488139261555219 0.936229931514539 0.333333333333333 7.1 7 1 abnormal vasodilation 0.280710757525738 0.488139261555219 0.936229931514539 0.333333333333333 7.1 7 1 abnormal sensory capabilities/reflexes/nociception 0.280710757525738 0.488139261555219 0.936229931514539 0.333333333333333 7.1 7 1 increased circulating total protein level 0.280710757525738 0.488139261555219 0.936229931514539 0.333333333333333 7.1 7 1 abnormal inner cell mass apoptosis 0.280710757525738 0.488139261555219 0.936229931514539 0.333333333333333 7.1 7 1 abnormal salivary gland morphology 0.302169637251802 0.516773442876493 0.936229931514539 0.333333333333333 7.1 7 1 abnormal anxiety-related response 0.302169637251802 0.516773442876493 0.936229931514539 0.333333333333333 7.1 7 1 liver degeneration 0.302169637251802 0.516773442876493 0.936229931514539 0.333333333333333 7.1 7 1 decreased cochlear outer hair cell number 0.302169637251802 0.516773442876493 0.936229931514539 0.333333333333333 7.1 7 1 abnormal bile salt homeostasis 0.302169637251802 0.516773442876493 0.936229931514539 0.333333333333333 7.1 7 1 increased bone ossification 0.302169637251802 0.516773442876493 0.936229931514539 0.333333333333333 7.1 7 1 abnormal stomach glandular epithelium morphology 0.326775918482443 0.55258674182534 0.936229931514539 0.333333333333333 7.1 7 1 absent spleen 0.326775918482443 0.55258674182534 0.936229931514539 0.333333333333333 7.1 7 1 decreased activity of thyroid 0.326775918482443 0.55258674182534 0.936229931514539 0.333333333333333 7.1 7 1 increased susceptibility to autoimmune disorder 0.326775918482443 0.55258674182534 0.936229931514539 0.333333333333333 7.1 7 1 abnormal sperm axoneme morphology 0.326775918482443 0.55258674182534 0.936229931514539 0.333333333333333 7.1 7 1 small thoracic cage 0.326775918482443 0.55258674182534 0.936229931514539 0.333333333333333 7.1 7 1 abnormal macrophage chemotaxis 0.326775918482443 0.55258674182534 0.936229931514539 0.333333333333333 7.1 7 1 decreased chondrocyte number 0.355586791087009 0.588308708233412 0.936229931514539 0.333333333333333 7.1 7 1 vagina atresia 0.355586791087009 0.588308708233412 0.936229931514539 0.333333333333333 7.1 7 1 no suckling reflex 0.355586791087009 0.588308708233412 0.936229931514539 0.333333333333333 7.1 7 1 audiogenic seizures 0.355586791087009 0.588308708233412 0.936229931514539 0.333333333333333 7.1 7 1 placental labyrinth hypoplasia 0.355586791087009 0.588308708233412 0.936229931514539 0.333333333333333 7.1 7 1 abnormal cricoid cartilage morphology 0.355586791087009 0.588308708233412 0.936229931514539 0.333333333333333 7.1 7 1 altered righting response 0.355586791087009 0.588308708233412 0.936229931514539 0.333333333333333 7.1 7 1 abnormal pericyte morphology 0.355586791087009 0.588308708233412 0.936229931514539 0.333333333333333 7.1 7 1 abnormal ear development 0.355586791087009 0.588308708233412 0.936229931514539 0.333333333333333 7.1 7 1 abnormal cerebral aqueduct morphology 0.355586791087009 0.588308708233412 0.936229931514539 0.333333333333333 7.1 7 1 lactation failure 0.355586791087009 0.588308708233412 0.936229931514539 0.333333333333333 7.1 7 1 abnormal spatial learning 0.0302086580970147 0.138215496264186 0.930486189603407 0.331288343558282 7.1 7 1 abnormal eye electrophysiology 0.0572622026704988 0.209989690908866 0.928492494064006 0.330578512396694 7.1 7 1 abnormal maternal nurturing 0.155082196877152 0.40436788755966 0.920881899850366 0.327868852459016 7.1 7 1 abnormal enzyme/coenzyme level 0.163812378708963 0.412211272243401 0.920088036143599 0.327586206896552 7.1 7 1 abnormal lymphocyte physiology 0.205742067093012 0.462524529501914 0.915877106916397 0.326086956521739 7.1 7 1 increased brown adipose tissue amount 0.247193694430071 0.485224171660348 0.910926419851984 0.324324324324324 7.1 7 1 abnormal long bone metaphysis morphology 0.247193694430071 0.485224171660348 0.910926419851984 0.324324324324324 7.1 7 1 abnormal skin physiology 0.263679113252425 0.4869352592542 0.908693757058229 0.323529411764706 7.1 7 1 abnormal cranial ganglia morphology 0.281875588345474 0.488139261555219 0.906028965981812 0.32258064516129 7.1 7 1 enhanced long term potentiation 0.195757970757429 0.442679956599187 0.902793148246163 0.321428571428571 7.1 7 1 abnormal circulating cholesterol level 0.302109419702941 0.516773442876493 0.902793148246163 0.321428571428571 7.1 7 1 failure of blastocyst to hatch from the zona pellucida 0.302109419702941 0.516773442876493 0.902793148246163 0.321428571428571 7.1 7 1 decreased circulating progesterone level 0.302109419702941 0.516773442876493 0.902793148246163 0.321428571428571 7.1 7 1 decreased inflammatory response 0.135582378129069 0.357178404636869 0.902793148246163 0.321428571428571 7.1 7 1 abnormal feces composition 0.324816503715946 0.550583341051731 0.898780734253957 0.32 7.1 7 1 decreased acute inflammation 0.324816503715946 0.550583341051731 0.898780734253957 0.32 7.1 7 1 cochlear hair cell degeneration 0.247532249664702 0.485224171660348 0.893674025536606 0.318181818181818 7.1 7 1 intestinal ulcer 0.350599779948463 0.586319650105008 0.893674025536606 0.318181818181818 7.1 7 1 abnormal oogenesis 0.350599779948463 0.586319650105008 0.893674025536606 0.318181818181818 7.1 7 1 abnormal tracheal cartilage morphology 0.350599779948463 0.586319650105008 0.893674025536606 0.318181818181818 7.1 7 1 abnormal lysosome physiology 0.350599779948463 0.586319650105008 0.893674025536606 0.318181818181818 7.1 7 1 abnormal channel response 0.350599779948463 0.586319650105008 0.893674025536606 0.318181818181818 7.1 7 1 increased tumor growth/size 0.263328620964761 0.486468581247562 0.890560178757732 0.317073170731707 7.1 7 1 abnormal eye physiology 0.207640459217957 0.466581429362845 0.889418434938812 0.316666666666667 7.1 7 1 shiny skin 0.3803303986341 0.626330265873767 0.886954671961142 0.315789473684211 7.1 7 1 maternal imprinting 0.3803303986341 0.626330265873767 0.886954671961142 0.315789473684211 7.1 7 1 absent amnion 0.3803303986341 0.626330265873767 0.886954671961142 0.315789473684211 7.1 7 1 decreased eye pigmentation 0.3803303986341 0.626330265873767 0.886954671961142 0.315789473684211 7.1 7 1 decreased fertilization frequency 0.3803303986341 0.626330265873767 0.886954671961142 0.315789473684211 7.1 7 1 polyphagia 0.232624290723422 0.485224171660348 0.884217157541509 0.314814814814815 7.1 7 1 abnormal immune system physiology 0.1134128856523 0.328447938142791 0.883378241832267 0.314516129032258 7.1 7 1 thick epidermis 0.196347498946011 0.443609812559675 0.882731078285137 0.314285714285714 7.1 7 1 abnormal action potential 0.196347498946011 0.443609812559675 0.882731078285137 0.314285714285714 7.1 7 1 holoprosencephaly 0.299553507379691 0.513889206625505 0.882731078285137 0.314285714285714 7.1 7 1 abnormal long term potentiation 0.320503521440252 0.545997807385453 0.87771556079488 0.3125 7.1 7 1 decreased susceptibility to parasitic infection 0.320503521440252 0.545997807385453 0.87771556079488 0.3125 7.1 7 1 paternal imprinting 0.415339613556493 0.660586501740267 0.87771556079488 0.3125 7.1 7 1 small epididymis 0.415339613556493 0.660586501740267 0.87771556079488 0.3125 7.1 7 1 abnormal amnion morphology 0.415339613556493 0.660586501740267 0.87771556079488 0.3125 7.1 7 1 sepsis 0.415339613556493 0.660586501740267 0.87771556079488 0.3125 7.1 7 1 loose skin 0.415339613556493 0.660586501740267 0.87771556079488 0.3125 7.1 7 1 decreased creatinine clearance 0.415339613556493 0.660586501740267 0.87771556079488 0.3125 7.1 7 1 abnormal urinary bladder physiology 0.415339613556493 0.660586501740267 0.87771556079488 0.3125 7.1 7 1 decreased midbrain size 0.415339613556493 0.660586501740267 0.87771556079488 0.3125 7.1 7 1 abnormal cytokine secretion 0.0988023517502667 0.289482744380198 0.875435780117491 0.311688311688312 7.1 7 1 abnormal NK cell physiology 0.231416815991179 0.485224171660348 0.874837804857848 0.311475409836066 7.1 7 1 abnormal ovarian follicle morphology 0.278023607953806 0.488139261555219 0.873814602746903 0.311111111111111 7.1 7 1 increased neutrophil cell number 0.113165813645817 0.328279838418625 0.871662350030778 0.310344827586207 7.1 7 1 enlarged epididymis 0.343817737733712 0.580615493966469 0.871662350030778 0.310344827586207 7.1 7 1 increased retinal apoptosis 0.343817737733712 0.580615493966469 0.871662350030778 0.310344827586207 7.1 7 1 abnormal optic nerve morphology 0.295819283714366 0.508259053642677 0.869356364977786 0.30952380952381 7.1 7 1 abnormal leukocyte adhesion 0.315258736002807 0.538603094647652 0.864212244474959 0.307692307692308 7.1 7 1 increased autoantibody level 0.315258736002807 0.538603094647652 0.864212244474959 0.307692307692308 7.1 7 1 abnormal leukocyte migration 0.274739028748278 0.488139261555219 0.864212244474959 0.307692307692308 7.1 7 1 increased percent body fat/body weight 0.274739028748278 0.488139261555219 0.864212244474959 0.307692307692308 7.1 7 1 abnormal leukocyte cell number 0.369993338445387 0.610519687816185 0.864212244474959 0.307692307692308 7.1 7 1 abnormal stomach morphology 0.369993338445387 0.610519687816185 0.864212244474959 0.307692307692308 7.1 7 1 small seminal vesicle 0.369993338445387 0.610519687816185 0.864212244474959 0.307692307692308 7.1 7 1 no spontaneous movement 0.369993338445387 0.610519687816185 0.864212244474959 0.307692307692308 7.1 7 1 decreased Peyer's patch number 0.369993338445387 0.610519687816185 0.864212244474959 0.307692307692308 7.1 7 1 abnormal reflex 0.336593615538441 0.568802050714586 0.858210770554994 0.305555555555556 7.1 7 1 increased B cell proliferation 0.271046217125243 0.488139261555219 0.856888411894663 0.305084745762712 7.1 7 1 abnormal sleep pattern 0.309646782080403 0.529378948745707 0.854818633121971 0.304347826086957 7.1 7 1 abnormal retinal cone cell morphology 0.399709547457464 0.637357371346438 0.854818633121971 0.304347826086957 7.1 7 1 abnormal innervation pattern to muscle 0.399709547457464 0.637357371346438 0.854818633121971 0.304347826086957 7.1 7 1 failure of embryo implantation 0.399709547457464 0.637357371346438 0.854818633121971 0.304347826086957 7.1 7 1 pancreas inflammation 0.399709547457464 0.637357371346438 0.854818633121971 0.304347826086957 7.1 7 1 increased susceptibility to age related obesity 0.399709547457464 0.637357371346438 0.854818633121971 0.304347826086957 7.1 7 1 decreased effector memory CD8-positive, alpha-beta T cell number 0.399709547457464 0.637357371346438 0.854818633121971 0.304347826086957 7.1 7 1 decreased sensitivity to xenobiotic induced morbidity/mortality 0.360138584744313 0.595641442520929 0.851118119558672 0.303030303030303 7.1 7 1 decreased circulating phosphate level 0.350869038717681 0.586319650105008 0.842606938363085 0.3 7.1 7 1 small gonad 0.433930685596684 0.662439168519255 0.842606938363085 0.3 7.1 7 1 abnormal spleen marginal zone morphology 0.386294717690921 0.628925141032661 0.842606938363085 0.3 7.1 7 1 abnormal circulating protein level 0.322297226075936 0.546685543718984 0.842606938363085 0.3 7.1 7 1 decreased susceptibility to induced arthritis 0.315448485691991 0.538742264441351 0.837679412407746 0.298245614035088 7.1 7 1 abnormal T cell activation 0.28709091813385 0.494898585487147 0.835015884864319 0.297297297297297 7.1 7 1 abnormal pancreatic beta cell physiology 0.374416659084289 0.617613686652632 0.835015884864319 0.297297297297297 7.1 7 1 abnormal brain commissure morphology 0.415584862206195 0.660765321021355 0.832204383568479 0.296296296296296 7.1 7 1 increased liver weight 0.276482718661614 0.488139261555219 0.829840166569705 0.295454545454545 7.1 7 1 abnormal photoreceptor outer segment morphology 0.363683274944086 0.601104416228181 0.829840166569705 0.295454545454545 7.1 7 1 decreased macrophage cell number 0.363683274944086 0.601104416228181 0.829840166569705 0.295454545454545 7.1 7 1 hydroureter 0.474093853604934 0.685047029243261 0.826085233689299 0.294117647058824 7.1 7 1 abnormal glutamate-mediated receptor currents 0.474093853604934 0.685047029243261 0.826085233689299 0.294117647058824 7.1 7 1 abnormal involuntary movement 0.474093853604934 0.685047029243261 0.826085233689299 0.294117647058824 7.1 7 1 abnormal electroretinogram waveform feature 0.474093853604934 0.685047029243261 0.826085233689299 0.294117647058824 7.1 7 1 apnea 0.448709049194057 0.662439168519255 0.819201190075222 0.291666666666667 7.1 7 1 increased eosinophil cell number 0.354776103270259 0.588308708233412 0.815426069383631 0.290322580645161 7.1 7 1 decreased IgA level 0.385915917720469 0.628925141032661 0.810198979195274 0.288461538461538 7.1 7 1 increased circulating luteinizing hormone level 0.460975039207497 0.666865606297557 0.802482798441034 0.285714285714286 7.1 7 1 enhanced coordination 0.460975039207497 0.666865606297557 0.802482798441034 0.285714285714286 7.1 7 1 abnormal humoral immune response 0.328871335168128 0.555941179905347 0.802482798441034 0.285714285714286 7.1 7 1 abnormal pancreas morphology 0.423602010313803 0.662439168519255 0.802482798441034 0.285714285714286 7.1 7 1 increased vasoconstriction 0.486635104934636 0.702760420043488 0.802482798441034 0.285714285714286 7.1 7 1 increased keratinocyte proliferation 0.486635104934636 0.702760420043488 0.802482798441034 0.285714285714286 7.1 7 1 abnormal immune system morphology 0.433478409311018 0.662439168519255 0.793760159327544 0.282608695652174 7.1 7 1 abnormal intestinal mucosa morphology 0.460080494345177 0.665958818553173 0.783820407779614 0.27906976744186 7.1 7 1 abnormal left-right axis patterning 0.460080494345177 0.665958818553173 0.783820407779614 0.27906976744186 7.1 7 1 increased susceptibility to bacterial infection induced morbidity/mortality 0.428471351140205 0.662439168519255 0.780191609595449 0.277777777777778 7.1 7 1 abnormal white adipose tissue morphology 0.530754597882816 0.745905119905935 0.780191609595449 0.277777777777778 7.1 7 1 abnormal neutrophil morphology 0.530754597882816 0.745905119905935 0.780191609595449 0.277777777777778 7.1 7 1 impaired leukocyte tethering or rolling 0.530754597882816 0.745905119905935 0.780191609595449 0.277777777777778 7.1 7 1 aphagia 0.505606392149891 0.719094282717469 0.774810977805136 0.275862068965517 7.1 7 1 increased susceptibility to induced arthritis 0.505606392149891 0.719094282717469 0.774810977805136 0.275862068965517 7.1 7 1 abnormal CD8-positive, alpha-beta T cell physiology 0.505606392149891 0.719094282717469 0.774810977805136 0.275862068965517 7.1 7 1 decreased bone strength 0.505606392149891 0.719094282717469 0.774810977805136 0.275862068965517 7.1 7 1 absent vibrissae 0.513221110233728 0.723102527163069 0.766006307602805 0.272727272727273 7.1 7 1 diarrhea 0.513221110233728 0.723102527163069 0.766006307602805 0.272727272727273 7.1 7 1 increased activated T cell number 0.53764835180445 0.754527658738263 0.766006307602805 0.272727272727273 7.1 7 1 abnormal retinal outer plexiform layer morphology 0.53764835180445 0.754527658738263 0.766006307602805 0.272727272727273 7.1 7 1 abnormal temporal bone morphology 0.53764835180445 0.754527658738263 0.766006307602805 0.272727272727273 7.1 7 1 impaired humoral immune response 0.53764835180445 0.754527658738263 0.766006307602805 0.272727272727273 7.1 7 1 abnormal hair shaft morphology 0.502974455692898 0.716169981989745 0.760686819355563 0.270833333333333 7.1 7 1 abnormal hair growth 0.509188451108291 0.72148234799522 0.756185713915589 0.269230769230769 7.1 7 1 arrested B cell differentiation 0.526149125856586 0.74005990984917 0.753550920487312 0.268292682926829 7.1 7 1 gastrointestinal hemorrhage 0.548992455589516 0.769796354723181 0.748983945211631 0.266666666666667 7.1 7 1 arrested T cell differentiation 0.548992455589516 0.769796354723181 0.748983945211631 0.266666666666667 7.1 7 1 decreased eosinophil cell number 0.5254078943281 0.739226321912415 0.746058226675648 0.265625 7.1 7 1 abnormal inflammatory response 0.534713374714598 0.751256435810541 0.741182029115677 0.263888888888889 7.1 7 1 abnormal nail morphology 0.584477526185928 0.787709062185004 0.739128893300952 0.263157894736842 7.1 7 1 abnormal response to novelty 0.584477526185928 0.787709062185004 0.739128893300952 0.263157894736842 7.1 7 1 right-sided stomach 0.584477526185928 0.787709062185004 0.739128893300952 0.263157894736842 7.1 7 1 impaired natural killer cell mediated cytotoxicity 0.546368867981617 0.766549666725478 0.739128893300952 0.263157894736842 7.1 7 1 abnormal regulatory T cell physiology 0.586332635691622 0.787709062185004 0.732701685533118 0.260869565217391 7.1 7 1 increased susceptibility to fungal infection 0.586332635691622 0.787709062185004 0.732701685533118 0.260869565217391 7.1 7 1 abnormal digestive system physiology 0.57018018759086 0.787709062185004 0.730259346581341 0.26 7.1 7 1 abnormal body temperature homeostasis 0.590724915188885 0.787709062185004 0.72482317278545 0.258064516129032 7.1 7 1 autoimmune response 0.590724915188885 0.787709062185004 0.72482317278545 0.258064516129032 7.1 7 1 decreased susceptibility to bacterial infection induced morbidity/mortality 0.590724915188885 0.787709062185004 0.72482317278545 0.258064516129032 7.1 7 1 abnormal lens fiber morphology 0.595405747071666 0.787709062185004 0.720176870395799 0.256410256410256 7.1 7 1 abnormal spleen germinal center morphology 0.63095530205417 0.829326982224437 0.702172448635904 0.25 7.1 7 1 waved hair 0.634659806382343 0.832656259692025 0.702172448635904 0.25 7.1 7 1 abnormal hair texture 0.634659806382343 0.832656259692025 0.702172448635904 0.25 7.1 7 1 increased urine calcium level 0.634659806382343 0.832656259692025 0.702172448635904 0.25 7.1 7 1 enhanced behavioral response to xenobiotic 0.634659806382343 0.832656259692025 0.702172448635904 0.25 7.1 7 1 abnormal inhibitory postsynaptic currents 0.63835242141122 0.835631644828002 0.702172448635904 0.25 7.1 7 1 abnormal crypts of Lieberkuhn morphology 0.630476110066915 0.828916133082162 0.702172448635904 0.25 7.1 7 1 abnormal gametogenesis 0.63159841108193 0.829953009807872 0.702172448635904 0.25 7.1 7 1 decreased metastatic potential 0.632207164524144 0.830314319827776 0.702172448635904 0.25 7.1 7 1 abnormal retinal ganglion layer morphology 0.632207164524144 0.830314319827776 0.702172448635904 0.25 7.1 7 1 increased double-positive T cell number 0.670839046114622 0.868442428940995 0.677959605579494 0.241379310344828 7.1 7 1 abnormal stomach mucosa morphology 0.674939063780193 0.873522851796686 0.674085550690468 0.24 7.1 7 1 dry skin 0.680917525584752 0.881031128682481 0.668735665367528 0.238095238095238 7.1 7 1 abnormal estrous cycle 0.707922791057046 0.89185005963758 0.655360952060177 0.233333333333333 7.1 7 1 abnormal intestine physiology 0.742105504851926 0.930671763710191 0.634220276187268 0.225806451612903 7.1 7 1 abnormal adrenal gland morphology 0.794935920396988 0.977825200455336 0.585143707196587 0.208333333333333 7.1 7 1 hypopigmentation 0.794935920396988 0.977825200455336 0.585143707196587 0.208333333333333 7.1 7 1 decreased pancreatic beta cell number 0.827295190127493 1 0.578259663582509 0.205882352941176 7.1 7 1 increased susceptibility to parasitic infection 0.960358262807493 1 0.530530294524906 0.188888888888889 7.1 7 1 wrinkled skin 0.874219819145542 1 0.520127739730299 0.185185185185185 7.1 7 1 decreased cytotoxic T cell cytolysis 0.91445470691544 1 0.49565114021358 0.176470588235294 7.1 7 1 increased susceptibility to viral infection induced morbidity/mortality 0.91445470691544 1 0.49565114021358 0.176470588235294 7.1 7 1 skin photosensitivity 0.00172977044917389 0.0159658775225234 1.48036850186444 1 7.2 7 2 decreased cardiomyocyte apoptosis 0.00172977044917389 0.0159658775225234 1.48036850186444 1 7.2 7 2 absent popliteal lymph nodes 0.00172977044917389 0.0159658775225234 1.48036850186444 1 7.2 7 2 abnormal outer hair cell kinocilium morphology 0.00172977044917389 0.0159658775225234 1.48036850186444 1 7.2 7 2 dysmyelination 0.00172977044917389 0.0159658775225234 1.48036850186444 1 7.2 7 2 ductus venosus stenosis 0.00172977044917389 0.0159658775225234 1.48036850186444 1 7.2 7 2 decreased collagen level 0.00172977044917389 0.0159658775225234 1.48036850186444 1 7.2 7 2 delayed brain development 0.00429159198998465 0.0310781224893357 1.48036850186444 1 7.2 7 2 chromatolysis 0.00429159198998465 0.0310781224893357 1.48036850186444 1 7.2 7 2 decreased liver function 0.00429159198998465 0.0310781224893357 1.48036850186444 1 7.2 7 2 increased glycerol level 0.00429159198998465 0.0310781224893357 1.48036850186444 1 7.2 7 2 abnormal dermis papillary layer morphology 0.00429159198998465 0.0310781224893357 1.48036850186444 1 7.2 7 2 absent sperm mitochondrial sheath 0.00429159198998465 0.0310781224893357 1.48036850186444 1 7.2 7 2 abnormal intestinal enteroendocrine cell morphology 0.00429159198998465 0.0310781224893357 1.48036850186444 1 7.2 7 2 thymus cortex atrophy 0.00429159198998465 0.0310781224893357 1.48036850186444 1 7.2 7 2 abnormal vertebral artery origin 0.00429159198998465 0.0310781224893357 1.48036850186444 1 7.2 7 2 additional anastomosis between intracranial vertebral arteries 0.00429159198998465 0.0310781224893357 1.48036850186444 1 7.2 7 2 decreased hippocampus volume 0.00429159198998465 0.0310781224893357 1.48036850186444 1 7.2 7 2 decreased retinal apoptosis 0.00429159198998465 0.0310781224893357 1.48036850186444 1 7.2 7 2 heart hyperplasia 0.000280977583799907 0.00358034519309256 1.48036850186444 1 7.2 7 2 abnormal hippocampus granule cell morphology 0.000280977583799907 0.00358034519309256 1.48036850186444 1 7.2 7 2 cerebellum atrophy 0.000280977583799907 0.00358034519309256 1.48036850186444 1 7.2 7 2 abnormal cerebellum deep nucleus morphology 0.000697171390164434 0.00750741919062351 1.48036850186444 1 7.2 7 2 abnormal pineal gland morphology 0.0106470530067502 0.0634360343815358 1.48036850186444 1 7.2 7 2 absent lacrimal glands 0.0106470530067502 0.0634360343815358 1.48036850186444 1 7.2 7 2 vascular inflammation 0.0106470530067502 0.0634360343815358 1.48036850186444 1 7.2 7 2 increased hepatic hemangioma incidence 0.0106470530067502 0.0634360343815358 1.48036850186444 1 7.2 7 2 increased urine microalbumin level 0.0106470530067502 0.0634360343815358 1.48036850186444 1 7.2 7 2 increased heart right ventricle weight 0.0106470530067502 0.0634360343815358 1.48036850186444 1 7.2 7 2 erythroblastosis 0.0106470530067502 0.0634360343815358 1.48036850186444 1 7.2 7 2 abnormal mismatch repair 0.0106470530067502 0.0634360343815358 1.48036850186444 1 7.2 7 2 enlarged eye anterior chamber 0.0106470530067502 0.0634360343815358 1.48036850186444 1 7.2 7 2 abnormal cranium size 0.0106470530067502 0.0634360343815358 1.48036850186444 1 7.2 7 2 increased T follicular helper cell number 0.0106470530067502 0.0634360343815358 1.48036850186444 1 7.2 7 2 prolonged ST segment 0.0106470530067502 0.0634360343815358 1.48036850186444 1 7.2 7 2 abnormal lung alveolus development 0.0106470530067502 0.0634360343815358 1.48036850186444 1 7.2 7 2 midface hypoplasia 0.0106470530067502 0.0634360343815358 1.48036850186444 1 7.2 7 2 abnormal mitophagy 0.0106470530067502 0.0634360343815358 1.48036850186444 1 7.2 7 2 increased brain size 5.11536063054206e-06 0.000105160822879945 1.39328800175477 0.941176470588235 7.2 7 2 heterochrony 2.79436441149083e-05 0.00046966091037726 1.38167726840681 0.933333333333333 7.2 7 2 abnormal thymus involution 0.000345318793561899 0.0042106887205158 1.35700446004241 0.916666666666667 7.2 7 2 decreased synaptic depression 0.000345318793561899 0.0042106887205158 1.35700446004241 0.916666666666667 7.2 7 2 decreased keratinocyte proliferation 0.000345318793561899 0.0042106887205158 1.35700446004241 0.916666666666667 7.2 7 2 decreased red blood cell distribution width 0.000345318793561899 0.0042106887205158 1.35700446004241 0.916666666666667 7.2 7 2 abnormal cerebral cortex pyramidal cell morphology 1.12134513932787e-06 2.65652003245531e-05 1.34578954714949 0.909090909090909 7.2 7 2 abnormal thrombopoiesis 0.000789266888927833 0.00835447398386376 1.34578954714949 0.909090909090909 7.2 7 2 abnormal spinal cord ventral horn morphology 0.000789266888927833 0.00835447398386376 1.34578954714949 0.909090909090909 7.2 7 2 reduced sympathetic cervical ganglion size 0.000789266888927833 0.00835447398386376 1.34578954714949 0.909090909090909 7.2 7 2 ketoaciduria 0.0017906511280361 0.0162563674488679 1.332331651678 0.9 7.2 7 2 osteosclerosis 0.0017906511280361 0.0162563674488679 1.332331651678 0.9 7.2 7 2 lethality during fetal growth through weaning, complete penetrance 0.0017906511280361 0.0162563674488679 1.332331651678 0.9 7.2 7 2 abnormal kindling response 0.00402672184108066 0.0300794912302947 1.31588311276839 0.888888888888889 7.2 7 2 abnormal vomeronasal organ morphology 0.00402672184108066 0.0300794912302947 1.31588311276839 0.888888888888889 7.2 7 2 abnormal posterior semicircular canal morphology 0.00402672184108066 0.0300794912302947 1.31588311276839 0.888888888888889 7.2 7 2 decreased cellular sensitivity to ionizing radiation 0.00402672184108066 0.0300794912302947 1.31588311276839 0.888888888888889 7.2 7 2 increased neuronal precursor cell number 0.00402672184108066 0.0300794912302947 1.31588311276839 0.888888888888889 7.2 7 2 abnormal CNS synapse formation 0.00402672184108066 0.0300794912302947 1.31588311276839 0.888888888888889 7.2 7 2 liver hyperplasia 0.00402672184108066 0.0300794912302947 1.31588311276839 0.888888888888889 7.2 7 2 multiflagellated sperm 0.00402672184108066 0.0300794912302947 1.31588311276839 0.888888888888889 7.2 7 2 abnormal ventricle myocardium morphology 0.00402672184108066 0.0300794912302947 1.31588311276839 0.888888888888889 7.2 7 2 abnormal oxidative phosphorylation 0.00402672184108066 0.0300794912302947 1.31588311276839 0.888888888888889 7.2 7 2 abnormal infrahyoid muscle connection 0.00402672184108066 0.0300794912302947 1.31588311276839 0.888888888888889 7.2 7 2 abnormal Schwann cell morphology 5.03195743683853e-07 1.29709783669801e-05 1.30955675164932 0.884615384615385 7.2 7 2 increased fibroblast apoptosis 4.44841367100603e-08 1.45597750087204e-06 1.29532243913139 0.875 7.2 7 2 abnormal bone marrow development 0.0089579638622401 0.0559872741390006 1.29532243913139 0.875 7.2 7 2 increased sensitivity to skin irradiation 0.0089579638622401 0.0559872741390006 1.29532243913139 0.875 7.2 7 2 poor grooming 0.0089579638622401 0.0559872741390006 1.29532243913139 0.875 7.2 7 2 decreased aerobic running capacity 0.0089579638622401 0.0559872741390006 1.29532243913139 0.875 7.2 7 2 early eyelid opening 0.0089579638622401 0.0559872741390006 1.29532243913139 0.875 7.2 7 2 colon polyps 0.0089579638622401 0.0559872741390006 1.29532243913139 0.875 7.2 7 2 tau protein deposits 0.0089579638622401 0.0559872741390006 1.29532243913139 0.875 7.2 7 2 abnormal extraembryonic tissue physiology 0.0089579638622401 0.0559872741390006 1.29532243913139 0.875 7.2 7 2 accumulation of giant lysosomes in kidney/renal tubule cells 0.0089579638622401 0.0559872741390006 1.29532243913139 0.875 7.2 7 2 ocular hypertension 0.0089579638622401 0.0559872741390006 1.29532243913139 0.875 7.2 7 2 abnormal meiotic spindle morphology 0.0089579638622401 0.0559872741390006 1.29532243913139 0.875 7.2 7 2 abnormal base-excision repair 0.0089579638622401 0.0559872741390006 1.29532243913139 0.875 7.2 7 2 increased heart right ventricle size 0.0089579638622401 0.0559872741390006 1.29532243913139 0.875 7.2 7 2 delayed suture closure 0.0089579638622401 0.0559872741390006 1.29532243913139 0.875 7.2 7 2 decreased alveolar lamellar body number 0.0089579638622401 0.0559872741390006 1.29532243913139 0.875 7.2 7 2 abnormal maxillary prominence morphology 0.0089579638622401 0.0559872741390006 1.29532243913139 0.875 7.2 7 2 decreased cranium length 0.0089579638622401 0.0559872741390006 1.29532243913139 0.875 7.2 7 2 abnormal heart echocardiography feature 0.0089579638622401 0.0559872741390006 1.29532243913139 0.875 7.2 7 2 abnormal umbilical vein topology 0.0089579638622401 0.0559872741390006 1.29532243913139 0.875 7.2 7 2 embryo cyst 0.0089579638622401 0.0559872741390006 1.29532243913139 0.875 7.2 7 2 dilated heart 5.30828438640674e-06 0.000108232437796613 1.28727695814299 0.869565217391304 7.2 7 2 abnormal optic cup morphology 2.10506846370324e-07 5.88354809377731e-06 1.28298603494918 0.866666666666667 7.2 7 2 abnormal trophectoderm morphology 0.00030529562221883 0.00382580786029894 1.28298603494918 0.866666666666667 7.2 7 2 immune system phenotype 0.00030529562221883 0.00382580786029894 1.28298603494918 0.866666666666667 7.2 7 2 embryonic lethality before implantation, incomplete penetrance 1.15142001953e-05 0.000216162814987236 1.27850006979202 0.863636363636364 7.2 7 2 increased muscle cell glucose uptake 2.48170048639131e-05 0.000428696524992944 1.26888728731238 0.857142857142857 7.2 7 2 lysosomal protein accumulation 0.00066141163810994 0.00731728934807907 1.26888728731238 0.857142857142857 7.2 7 2 cochlear degeneration 0.0196625212348492 0.102645375806269 1.26888728731238 0.857142857142857 7.2 7 2 maxilla hypoplasia 0.0196625212348492 0.102645375806269 1.26888728731238 0.857142857142857 7.2 7 2 retina hyperplasia 0.0196625212348492 0.102645375806269 1.26888728731238 0.857142857142857 7.2 7 2 excessive tearing 0.0196625212348492 0.102645375806269 1.26888728731238 0.857142857142857 7.2 7 2 limp posture 0.0196625212348492 0.102645375806269 1.26888728731238 0.857142857142857 7.2 7 2 abnormal circulating alanine transaminase level 0.0196625212348492 0.102645375806269 1.26888728731238 0.857142857142857 7.2 7 2 abnormal gastrulation movements 0.0196625212348492 0.102645375806269 1.26888728731238 0.857142857142857 7.2 7 2 aorta coarctation 0.0196625212348492 0.102645375806269 1.26888728731238 0.857142857142857 7.2 7 2 abnormal Purkinje cell innervation 0.0196625212348492 0.102645375806269 1.26888728731238 0.857142857142857 7.2 7 2 abnormal optic tract morphology 0.0196625212348492 0.102645375806269 1.26888728731238 0.857142857142857 7.2 7 2 heart hemorrhage 0.0196625212348492 0.102645375806269 1.26888728731238 0.857142857142857 7.2 7 2 abnormal sperm annulus morphology 0.0196625212348492 0.102645375806269 1.26888728731238 0.857142857142857 7.2 7 2 abnormal cerebellum white matter morphology 0.0196625212348492 0.102645375806269 1.26888728731238 0.857142857142857 7.2 7 2 decreased DN2 thymocyte number 0.0196625212348492 0.102645375806269 1.26888728731238 0.857142857142857 7.2 7 2 increased oligodendrocyte number 0.0196625212348492 0.102645375806269 1.26888728731238 0.857142857142857 7.2 7 2 decreased skeletal muscle glycogen level 0.0196625212348492 0.102645375806269 1.26888728731238 0.857142857142857 7.2 7 2 heart block 0.0196625212348492 0.102645375806269 1.26888728731238 0.857142857142857 7.2 7 2 abnormal conotruncal ridge morphology 0.0196625212348492 0.102645375806269 1.26888728731238 0.857142857142857 7.2 7 2 abnormal aortic valve cusp morphology 0.0196625212348492 0.102645375806269 1.26888728731238 0.857142857142857 7.2 7 2 abnormal impulsive behavior control 0.0196625212348492 0.102645375806269 1.26888728731238 0.857142857142857 7.2 7 2 decreased areal bone mineral density 0.0196625212348492 0.102645375806269 1.26888728731238 0.857142857142857 7.2 7 2 decreased circulating total protein level 6.0935265437247e-12 4.09666142635546e-10 1.26504217432052 0.854545454545454 7.2 7 2 spleen atrophy 5.31168366990934e-05 0.000835850987118763 1.25831322658478 0.85 7.2 7 2 abnormal nerve conduction 4.44226106746919e-06 9.28581882800808e-05 1.25261950157761 0.846153846153846 7.2 7 2 increased thymocyte apoptosis 4.44226106746919e-06 9.28581882800808e-05 1.25261950157761 0.846153846153846 7.2 7 2 abnormal grip strength 0.00141882173400179 0.0137327590012819 1.25261950157761 0.846153846153846 7.2 7 2 increased synaptic depression 0.00141882173400179 0.0137327590012819 1.25261950157761 0.846153846153846 7.2 7 2 abnormal telomere length 0.00141882173400179 0.0137327590012819 1.25261950157761 0.846153846153846 7.2 7 2 axonal dystrophy 0.00141882173400179 0.0137327590012819 1.25261950157761 0.846153846153846 7.2 7 2 scoliosis 3.80471350486379e-07 1.01765858530631e-05 1.24906092344812 0.84375 7.2 7 2 unresponsive to tactile stimuli 0.000112816410211937 0.00161746870548815 1.24662610683322 0.842105263157895 7.2 7 2 abnormal egg cylinder morphology 9.38302248450344e-06 0.000180932313412421 1.24350954156613 0.84 7.2 7 2 increased cellular sensitivity to ionizing radiation 9.38302248450344e-06 0.000180932313412421 1.24350954156613 0.84 7.2 7 2 abnormal object recognition memory 8.00835325410436e-07 1.96359666573543e-05 1.2415993886605 0.838709677419355 7.2 7 2 small heart 1.12672453455864e-09 5.14261886186169e-08 1.23364041822037 0.833333333333333 7.2 7 2 abnormal digestive system morphology 1.96846239981505e-05 0.000347273065215598 1.23364041822037 0.833333333333333 7.2 7 2 abnormal respiratory function 0.00300900736575751 0.0242622555018535 1.23364041822037 0.833333333333333 7.2 7 2 abnormal corticospinal tract morphology 0.00300900736575751 0.0242622555018535 1.23364041822037 0.833333333333333 7.2 7 2 loss of dopaminergic neurons 0.00300900736575751 0.0242622555018535 1.23364041822037 0.833333333333333 7.2 7 2 abnormal vascular endothelial cell development 0.00300900736575751 0.0242622555018535 1.23364041822037 0.833333333333333 7.2 7 2 increased osteosarcoma incidence 0.00300900736575751 0.0242622555018535 1.23364041822037 0.833333333333333 7.2 7 2 abnormal thymus corticomedullary boundary morphology 0.00300900736575751 0.0242622555018535 1.23364041822037 0.833333333333333 7.2 7 2 abnormal pulmonary valve cusp morphology 0.00300900736575751 0.0242622555018535 1.23364041822037 0.833333333333333 7.2 7 2 embryonic lethality between implantation and placentation, incomplete penetrance 0.00300900736575751 0.0242622555018535 1.23364041822037 0.833333333333333 7.2 7 2 echinocytosis 0.0424243580905782 0.173570050576173 1.23364041822037 0.833333333333333 7.2 7 2 thin tail 0.0424243580905782 0.173570050576173 1.23364041822037 0.833333333333333 7.2 7 2 abnormal lacrimal gland physiology 0.0424243580905782 0.173570050576173 1.23364041822037 0.833333333333333 7.2 7 2 jumpy 0.0424243580905782 0.173570050576173 1.23364041822037 0.833333333333333 7.2 7 2 absent ectoplacental cone 0.0424243580905782 0.173570050576173 1.23364041822037 0.833333333333333 7.2 7 2 non-obstructive hydrocephaly 0.0424243580905782 0.173570050576173 1.23364041822037 0.833333333333333 7.2 7 2 abnormal gustatory system physiology 0.0424243580905782 0.173570050576173 1.23364041822037 0.833333333333333 7.2 7 2 abnormal gland physiology 0.0424243580905782 0.173570050576173 1.23364041822037 0.833333333333333 7.2 7 2 abnormal hippocampal fimbria morphology 0.0424243580905782 0.173570050576173 1.23364041822037 0.833333333333333 7.2 7 2 esophageal atresia 0.0424243580905782 0.173570050576173 1.23364041822037 0.833333333333333 7.2 7 2 enlarged pancreas 0.0424243580905782 0.173570050576173 1.23364041822037 0.833333333333333 7.2 7 2 ureter obstruction 0.0424243580905782 0.173570050576173 1.23364041822037 0.833333333333333 7.2 7 2 abnormal ST segment 0.0424243580905782 0.173570050576173 1.23364041822037 0.833333333333333 7.2 7 2 abnormal heart left atrium morphology 0.0424243580905782 0.173570050576173 1.23364041822037 0.833333333333333 7.2 7 2 abnormal motor nerve collateral sprouting 0.0424243580905782 0.173570050576173 1.23364041822037 0.833333333333333 7.2 7 2 abnormal extensor digitorum longus morphology 0.0424243580905782 0.173570050576173 1.23364041822037 0.833333333333333 7.2 7 2 abnormal eyelid development 0.0424243580905782 0.173570050576173 1.23364041822037 0.833333333333333 7.2 7 2 abnormal neural crest cell morphology 0.0424243580905782 0.173570050576173 1.23364041822037 0.833333333333333 7.2 7 2 abnormal aorta tunica adventitia morphology 0.0424243580905782 0.173570050576173 1.23364041822037 0.833333333333333 7.2 7 2 absent tongue 0.0424243580905782 0.173570050576173 1.23364041822037 0.833333333333333 7.2 7 2 abnormal olfactory bulb layer morphology 0.0424243580905782 0.173570050576173 1.23364041822037 0.833333333333333 7.2 7 2 ectopic hippocampus pyramidal cells 0.0424243580905782 0.173570050576173 1.23364041822037 0.833333333333333 7.2 7 2 abnormal heart right ventricle outflow tract morphology 0.0424243580905782 0.173570050576173 1.23364041822037 0.833333333333333 7.2 7 2 kidney microaneurysm 0.0424243580905782 0.173570050576173 1.23364041822037 0.833333333333333 7.2 7 2 cerebral arteriovenous malformation 0.0424243580905782 0.173570050576173 1.23364041822037 0.833333333333333 7.2 7 2 thick myocardium 0.0424243580905782 0.173570050576173 1.23364041822037 0.833333333333333 7.2 7 2 abnormal mandibular prominence morphology 0.0424243580905782 0.173570050576173 1.23364041822037 0.833333333333333 7.2 7 2 absent midbrain 0.0424243580905782 0.173570050576173 1.23364041822037 0.833333333333333 7.2 7 2 delayed limb development 0.0424243580905782 0.173570050576173 1.23364041822037 0.833333333333333 7.2 7 2 absent thymus corticomedullary boundary 0.0424243580905782 0.173570050576173 1.23364041822037 0.833333333333333 7.2 7 2 ciliary body hypoplasia 0.0424243580905782 0.173570050576173 1.23364041822037 0.833333333333333 7.2 7 2 abnormal Wolffian duct connection 0.0424243580905782 0.173570050576173 1.23364041822037 0.833333333333333 7.2 7 2 increased male germ cell apoptosis 0.0424243580905782 0.173570050576173 1.23364041822037 0.833333333333333 7.2 7 2 abnormal platelet alpha-granule morphology 0.0424243580905782 0.173570050576173 1.23364041822037 0.833333333333333 7.2 7 2 decreased capillary density 0.0424243580905782 0.173570050576173 1.23364041822037 0.833333333333333 7.2 7 2 abnormal lysosome morphology 1.45234057848637e-07 4.22537682922204e-06 1.23364041822037 0.833333333333333 7.2 7 2 abnormal synaptic transmission 1.67612312739769e-06 3.86051507352015e-05 1.23364041822037 0.833333333333333 7.2 7 2 blepharoptosis 0.000237579774746867 0.00311041941938332 1.23364041822037 0.833333333333333 7.2 7 2 absent inner cell mass 0.000237579774746867 0.00311041941938332 1.23364041822037 0.833333333333333 7.2 7 2 axon degeneration 1.00326393432107e-10 5.73705525660612e-09 1.23364041822037 0.833333333333333 7.2 7 2 embryonic lethality between somite formation and embryo turning, complete penetrance 3.12646860032896e-13 2.43034082603696e-11 1.22659104440197 0.828571428571429 7.2 7 2 absence seizures 0.000495589645561063 0.00570448269394579 1.21912700153542 0.823529411764706 7.2 7 2 abnormal embryonic-extraembryonic boundary morphology 0.000495589645561063 0.00570448269394579 1.21912700153542 0.823529411764706 7.2 7 2 aphakia 8.46796258726721e-05 0.00123181619507761 1.21121059243455 0.818181818181818 7.2 7 2 abnormal channel response 8.46796258726721e-05 0.00123181619507761 1.21121059243455 0.818181818181818 7.2 7 2 delayed hepatic development 0.00629688020402329 0.0420496362617662 1.21121059243455 0.818181818181818 7.2 7 2 abnormal hemoglobin 0.00629688020402329 0.0420496362617662 1.21121059243455 0.818181818181818 7.2 7 2 failure of somite differentiation 0.00629688020402329 0.0420496362617662 1.21121059243455 0.818181818181818 7.2 7 2 abnormal fear/anxiety-related behavior 0.00629688020402329 0.0420496362617662 1.21121059243455 0.818181818181818 7.2 7 2 fatigue 0.00629688020402329 0.0420496362617662 1.21121059243455 0.818181818181818 7.2 7 2 abnormal dorsal-ventral polarity of the somites 0.00629688020402329 0.0420496362617662 1.21121059243455 0.818181818181818 7.2 7 2 abnormal cell morphology 1.7721520772691e-19 3.26535429052363e-17 1.20766904099468 0.815789473684211 7.2 7 2 neurodegeneration 6.83868012123209e-10 3.33553270618918e-08 1.20622618670436 0.814814814814815 7.2 7 2 disorganized yolk sac vascular plexus 0.00102285222329112 0.010470555166406 1.20279940776486 0.8125 7.2 7 2 abnormal embryonic/fetal subventricular zone morphology 0.00017339112199861 0.00236334474504955 1.19839354912836 0.80952380952381 7.2 7 2 embryonic lethality before implantation, complete penetrance 1.94384088570049e-20 3.86824336254397e-18 1.19613774950647 0.808 7.2 7 2 abnormal cell differentiation 1.71391333368365e-07 4.90041312360698e-06 1.19151611125675 0.804878048780488 7.2 7 2 abnormal preimplantation embryo development 6.08910300527383e-05 0.000932101152345763 1.18429480149156 0.8 7.2 7 2 abnormal vascular regression 0.000351614704263313 0.00424583289735433 1.18429480149156 0.8 7.2 7 2 anencephaly 0.000351614704263313 0.00424583289735433 1.18429480149156 0.8 7.2 7 2 decreased paired-pulse facilitation 0.000351614704263313 0.00424583289735433 1.18429480149156 0.8 7.2 7 2 absent ductus venosus valve 0.000351614704263313 0.00424583289735433 1.18429480149156 0.8 7.2 7 2 abnormal seizure response to electrical stimulation 0.00208587570167439 0.0185462798975297 1.18429480149156 0.8 7.2 7 2 delayed intramembranous bone ossification 0.00208587570167439 0.0185462798975297 1.18429480149156 0.8 7.2 7 2 abnormal glial cell morphology 0.00208587570167439 0.0185462798975297 1.18429480149156 0.8 7.2 7 2 abnormal cerebral aqueduct morphology 0.00208587570167439 0.0185462798975297 1.18429480149156 0.8 7.2 7 2 decreased thymocyte apoptosis 0.00208587570167439 0.0185462798975297 1.18429480149156 0.8 7.2 7 2 absent trophoblast giant cells 0.0129710046932588 0.0743441801255331 1.18429480149156 0.8 7.2 7 2 abnormal PNS synaptic transmission 0.0129710046932588 0.0743441801255331 1.18429480149156 0.8 7.2 7 2 acrania 0.0129710046932588 0.0743441801255331 1.18429480149156 0.8 7.2 7 2 abnormal submandibular gland morphology 0.0129710046932588 0.0743441801255331 1.18429480149156 0.8 7.2 7 2 abnormal corneal endothelium morphology 0.0129710046932588 0.0743441801255331 1.18429480149156 0.8 7.2 7 2 ascites 0.0129710046932588 0.0743441801255331 1.18429480149156 0.8 7.2 7 2 abnormal spinal cord dorsal column morphology 0.0129710046932588 0.0743441801255331 1.18429480149156 0.8 7.2 7 2 abnormal hippocampus neuron morphology 0.0129710046932588 0.0743441801255331 1.18429480149156 0.8 7.2 7 2 thin ventricle myocardium compact layer 0.0129710046932588 0.0743441801255331 1.18429480149156 0.8 7.2 7 2 fusion of atlas and odontoid process 0.0129710046932588 0.0743441801255331 1.18429480149156 0.8 7.2 7 2 abnormal adaptive thermogenesis 0.0129710046932588 0.0743441801255331 1.18429480149156 0.8 7.2 7 2 abnormal apoptosis 4.14848052127732e-09 1.66441053172215e-07 1.17881195518835 0.796296296296296 7.2 7 2 abnormal cell cycle 1.96076191072123e-17 2.86905603112887e-15 1.17142203191013 0.791304347826087 7.2 7 2 increased neuron apoptosis 1.27748531455298e-12 9.3463079998545e-11 1.16967387801635 0.790123456790123 7.2 7 2 abnormal nasal septum morphology 0.000705442391752847 0.00758007753557325 1.16871197515614 0.789473684210526 7.2 7 2 liver hypoplasia 1.63025590910379e-08 5.67169450894499e-07 1.16721362647004 0.788461538461538 7.2 7 2 increased cardiomyocyte apoptosis 7.59559386276387e-06 0.000150550117399403 1.1663509408629 0.787878787878788 7.2 7 2 abnormal locomotor coordination 7.59559386276387e-06 0.000150550117399403 1.1663509408629 0.787878787878788 7.2 7 2 increased cellular sensitivity to gamma-irradiation 8.90824416432522e-08 2.70234845838524e-06 1.16539648019116 0.787234042553192 7.2 7 2 abnormal cell nucleus morphology 8.90824416432522e-08 2.70234845838524e-06 1.16539648019116 0.787234042553192 7.2 7 2 abnormal axon morphology 4.07873188748018e-16 4.83135503338426e-14 1.16510483943035 0.787037037037037 7.2 7 2 small superior cervical ganglion 4.260563522323e-05 0.000688191672842757 1.16314668003635 0.785714285714286 7.2 7 2 subcutaneous edema 4.260563522323e-05 0.000688191672842757 1.16314668003635 0.785714285714286 7.2 7 2 increased lactate dehydrogenase level 0.00419599208560521 0.0309260157420532 1.16314668003635 0.785714285714286 7.2 7 2 increased hemangioma incidence 0.00419599208560521 0.0309260157420532 1.16314668003635 0.785714285714286 7.2 7 2 amyloid beta deposits 0.00419599208560521 0.0309260157420532 1.16314668003635 0.785714285714286 7.2 7 2 abnormal voluntary movement 0.00419599208560521 0.0309260157420532 1.16314668003635 0.785714285714286 7.2 7 2 split sternum 0.00419599208560521 0.0309260157420532 1.16314668003635 0.785714285714286 7.2 7 2 pulmonary alveolar hemorrhage 0.00419599208560521 0.0309260157420532 1.16314668003635 0.785714285714286 7.2 7 2 testis degeneration 0.00419599208560521 0.0309260157420532 1.16314668003635 0.785714285714286 7.2 7 2 multiple persisting craniopharyngeal ducts 0.00419599208560521 0.0309260157420532 1.16314668003635 0.785714285714286 7.2 7 2 abnormal vitelline vein topology 0.00419599208560521 0.0309260157420532 1.16314668003635 0.785714285714286 7.2 7 2 abnormal dendritic spine morphology 3.20865148028029e-08 1.07134504123453e-06 1.16107333479564 0.784313725490196 7.2 7 2 decreased cell proliferation 3.83117611263635e-26 1.27067341069106e-23 1.16028882578565 0.783783783783784 7.2 7 2 abnormal respiratory electron transport chain 2.69600555559458e-06 6.01463122828835e-05 1.16028882578565 0.783783783783784 7.2 7 2 failure to gastrulate 1.75126553093792e-07 4.95031023660007e-06 1.1585492623287 0.782608695652174 7.2 7 2 small liver 9.6794388935609e-12 6.33621164414019e-10 1.15772408479142 0.782051282051282 7.2 7 2 increased embryonic tissue cell apoptosis 9.6794388935609e-12 6.33621164414019e-10 1.15772408479142 0.782051282051282 7.2 7 2 abnormal auditory brainstem response waveform shape 1.49686666556656e-05 0.000270796787679769 1.1565378920816 0.78125 7.2 7 2 abnormal myocardial trabeculae morphology 3.42353223093041e-07 9.25656133091238e-06 1.15139772367235 0.777777777777778 7.2 7 2 reduced long term depression 5.28331632774865e-06 0.000108166661442591 1.15139772367235 0.777777777777778 7.2 7 2 abnormal thymus cortex morphology 0.00139862419341076 0.013643441886703 1.15139772367235 0.777777777777778 7.2 7 2 abnormal bile duct morphology 0.00139862419341076 0.013643441886703 1.15139772367235 0.777777777777778 7.2 7 2 abnormal metacarpal bone morphology 0.00139862419341076 0.013643441886703 1.15139772367235 0.777777777777778 7.2 7 2 darkened coat color 0.00139862419341076 0.013643441886703 1.15139772367235 0.777777777777778 7.2 7 2 increased effector memory CD4-positive, alpha-beta T cell number 0.00139862419341076 0.013643441886703 1.15139772367235 0.777777777777778 7.2 7 2 increased effector memory CD8-positive, alpha-beta T cell number 0.00139862419341076 0.013643441886703 1.15139772367235 0.777777777777778 7.2 7 2 abnormal hypoglossal nerve topology 0.00139862419341076 0.013643441886703 1.15139772367235 0.777777777777778 7.2 7 2 abnormal head movements 0.0262173109362982 0.12144713396162 1.15139772367235 0.777777777777778 7.2 7 2 crypts of Lieberkuhn abscesses 0.0262173109362982 0.12144713396162 1.15139772367235 0.777777777777778 7.2 7 2 abnormal ion homeostasis 0.0262173109362982 0.12144713396162 1.15139772367235 0.777777777777778 7.2 7 2 increased pheochromocytoma incidence 0.0262173109362982 0.12144713396162 1.15139772367235 0.777777777777778 7.2 7 2 abnormal NMDA-mediated synaptic currents 0.0262173109362982 0.12144713396162 1.15139772367235 0.777777777777778 7.2 7 2 premature neuronal precursor differentiation 0.0262173109362982 0.12144713396162 1.15139772367235 0.777777777777778 7.2 7 2 decreased muscle weight 0.0262173109362982 0.12144713396162 1.15139772367235 0.777777777777778 7.2 7 2 abnormal inguinal fat pad morphology 0.0262173109362982 0.12144713396162 1.15139772367235 0.777777777777778 7.2 7 2 positive geotaxis 0.0262173109362982 0.12144713396162 1.15139772367235 0.777777777777778 7.2 7 2 enhanced conditioned place preference behavior 0.0262173109362982 0.12144713396162 1.15139772367235 0.777777777777778 7.2 7 2 abnormal optic chiasm morphology 0.0262173109362982 0.12144713396162 1.15139772367235 0.777777777777778 7.2 7 2 axonal spheroids 0.0262173109362982 0.12144713396162 1.15139772367235 0.777777777777778 7.2 7 2 abnormal telomere morphology 0.0262173109362982 0.12144713396162 1.15139772367235 0.777777777777778 7.2 7 2 retropulsion 0.0262173109362982 0.12144713396162 1.15139772367235 0.777777777777778 7.2 7 2 shortened ST segment 0.0262173109362982 0.12144713396162 1.15139772367235 0.777777777777778 7.2 7 2 iris coloboma 0.0262173109362982 0.12144713396162 1.15139772367235 0.777777777777778 7.2 7 2 fusion of atlas and occipital bones 0.0262173109362982 0.12144713396162 1.15139772367235 0.777777777777778 7.2 7 2 abnormal pulmonary alveolar system morphology 0.0262173109362982 0.12144713396162 1.15139772367235 0.777777777777778 7.2 7 2 abnormal ductus venosus valve topology 0.0262173109362982 0.12144713396162 1.15139772367235 0.777777777777778 7.2 7 2 symmetric azygos veins 0.0262173109362982 0.12144713396162 1.15139772367235 0.777777777777778 7.2 7 2 increased cardiac muscle glycogen level 0.0262173109362982 0.12144713396162 1.15139772367235 0.777777777777778 7.2 7 2 decreased fatty acid oxidation 0.0262173109362982 0.12144713396162 1.15139772367235 0.777777777777778 7.2 7 2 increased endoplasmic reticulum stress 0.0262173109362982 0.12144713396162 1.15139772367235 0.777777777777778 7.2 7 2 increased brain weight 8.38305519419073e-05 0.00122663822326761 1.15139772367235 0.777777777777778 7.2 7 2 abnormal fetal cardiomyocyte proliferation 8.38305519419073e-05 0.00122663822326761 1.15139772367235 0.777777777777778 7.2 7 2 abnormal eye muscle morphology 8.38305519419073e-05 0.00122663822326761 1.15139772367235 0.777777777777778 7.2 7 2 abnormal posture 1.3304801604199e-11 8.59628415336236e-10 1.14728558894494 0.775 7.2 7 2 abnormal mitochondrial ATP synthesis coupled electron transport 2.92677322855309e-05 0.000488613986981598 1.14609174337892 0.774193548387097 7.2 7 2 muscular atrophy 6.65337793693608e-07 1.67174521395237e-05 1.14392111507707 0.772727272727273 7.2 7 2 abnormal tail movements 0.000475010208826798 0.00549575764863562 1.14392111507707 0.772727272727273 7.2 7 2 abnormal lysosome physiology 0.000475010208826798 0.00549575764863562 1.14392111507707 0.772727272727273 7.2 7 2 abnormal mesenteric lymph node morphology 0.000475010208826798 0.00549575764863562 1.14392111507707 0.772727272727273 7.2 7 2 holoprosencephaly 1.02792586324072e-05 0.000195188212581015 1.14199855858114 0.771428571428571 7.2 7 2 abnormal placenta vasculature 8.46997005086852e-08 2.61727335422801e-06 1.13874500143419 0.769230769230769 7.2 7 2 short premaxilla 0.00830962613827659 0.0535497280284016 1.13874500143419 0.769230769230769 7.2 7 2 excessive scratching 0.00830962613827659 0.0535497280284016 1.13874500143419 0.769230769230769 7.2 7 2 abnormal tail bud morphology 0.00830962613827659 0.0535497280284016 1.13874500143419 0.769230769230769 7.2 7 2 abnormal coping response 0.00830962613827659 0.0535497280284016 1.13874500143419 0.769230769230769 7.2 7 2 small pituitary gland 0.00830962613827659 0.0535497280284016 1.13874500143419 0.769230769230769 7.2 7 2 orthokeratosis 0.00830962613827659 0.0535497280284016 1.13874500143419 0.769230769230769 7.2 7 2 failure of heart looping 3.62745677408648e-06 7.7787057978794e-05 1.13874500143419 0.769230769230769 7.2 7 2 enhanced paired-pulse facilitation 5.67471370054821e-05 0.000874046460068958 1.13494918476274 0.766666666666667 7.2 7 2 neuron degeneration 4.56725463295555e-07 1.19589956836599e-05 1.13389927802383 0.765957446808511 7.2 7 2 abnormal direction of heart looping 1.98469558112417e-05 0.000348899664879603 1.13204650142575 0.764705882352941 7.2 7 2 abnormal interatrial septum morphology 0.00273645560091379 0.0227276571194425 1.13204650142575 0.764705882352941 7.2 7 2 hyperlipidemia 0.00273645560091379 0.0227276571194425 1.13204650142575 0.764705882352941 7.2 7 2 increased regulatory T cell number 0.00273645560091379 0.0227276571194425 1.13204650142575 0.764705882352941 7.2 7 2 abnormal head morphology 5.81372169778652e-08 1.85405547733897e-06 1.13046321960558 0.763636363636364 7.2 7 2 decreased total retina thickness 6.98026262886703e-06 0.000139465086661098 1.1297549093176 0.763157894736842 7.2 7 2 seizures 5.30503942926216e-15 5.38623901236311e-13 1.1297549093176 0.763157894736842 7.2 7 2 ataxia 2.33284063834502e-25 6.82698951515676e-23 1.12859776874814 0.762376237623762 7.2 7 2 abnormal optic nerve morphology 2.46604534826755e-06 5.55139167766111e-05 1.12789981094434 0.761904761904762 7.2 7 2 embryonic lethality at implantation, complete penetrance 0.000921930167510364 0.00959540289406707 1.12789981094434 0.761904761904762 7.2 7 2 absent segment of posterior cerebral artery 0.000921930167510364 0.00959540289406707 1.12789981094434 0.761904761904762 7.2 7 2 abnormal myelin sheath morphology 8.74438082181567e-07 2.10160843422864e-05 1.12636733837512 0.760869565217391 7.2 7 2 embryonic lethality between implantation and placentation, complete penetrance 8.74438082181567e-07 2.10160843422864e-05 1.12636733837512 0.760869565217391 7.2 7 2 decreased embryo size 3.20541846171339e-57 3.98673921175603e-54 1.12421289995145 0.759414225941423 7.2 7 2 impaired limb coordination 1.10908798564198e-07 3.30401959794541e-06 1.12398349215634 0.759259259259259 7.2 7 2 abnormal cell adhesion 1.10908798564198e-07 3.30401959794541e-06 1.12398349215634 0.759259259259259 7.2 7 2 decreased brown adipose tissue amount 3.80095191334835e-05 0.000622030781871974 1.12149128929125 0.757575757575758 7.2 7 2 abnormal chromosome morphology 1.33327276188946e-05 0.000245667851496299 1.1202788662758 0.756756756756757 7.2 7 2 lethality at weaning, incomplete penetrance 4.70014340577472e-06 9.76512957822571e-05 1.11930301360482 0.75609756097561 7.2 7 2 decreased brain weight 7.51193044355801e-08 2.35043106645919e-06 1.11676922070476 0.754385964912281 7.2 7 2 hemolytic anemia 0.000601931581354841 0.00677513488063424 1.11027637639833 0.75 7.2 7 2 blindness 0.000601931581354841 0.00677513488063424 1.11027637639833 0.75 7.2 7 2 abnormal adipose tissue distribution 0.0161604987188207 0.0877712676049485 1.11027637639833 0.75 7.2 7 2 abnormal embryonic growth/weight/body size 0.0161604987188207 0.0877712676049485 1.11027637639833 0.75 7.2 7 2 increased growth rate 0.0161604987188207 0.0877712676049485 1.11027637639833 0.75 7.2 7 2 abnormal AMPA-mediated synaptic currents 0.0161604987188207 0.0877712676049485 1.11027637639833 0.75 7.2 7 2 small intestinal inflammation 0.0161604987188207 0.0877712676049485 1.11027637639833 0.75 7.2 7 2 absent ovary 0.0161604987188207 0.0877712676049485 1.11027637639833 0.75 7.2 7 2 abnormal nucleotide metabolism 0.0161604987188207 0.0877712676049485 1.11027637639833 0.75 7.2 7 2 decreased left ventricle systolic pressure 0.0161604987188207 0.0877712676049485 1.11027637639833 0.75 7.2 7 2 pale placenta 0.0161604987188207 0.0877712676049485 1.11027637639833 0.75 7.2 7 2 hematuria 0.0161604987188207 0.0877712676049485 1.11027637639833 0.75 7.2 7 2 abnormal somatic nervous system physiology 0.0161604987188207 0.0877712676049485 1.11027637639833 0.75 7.2 7 2 decreased mammary gland epithelial cell proliferation 0.0161604987188207 0.0877712676049485 1.11027637639833 0.75 7.2 7 2 persistent right dorsal aorta 0.0161604987188207 0.0877712676049485 1.11027637639833 0.75 7.2 7 2 prenatal growth retardation 0.0161604987188207 0.0877712676049485 1.11027637639833 0.75 7.2 7 2 abnormal vitelline vein connection 0.0161604987188207 0.0877712676049485 1.11027637639833 0.75 7.2 7 2 abnormal trophoblast giant cell morphology 2.52670855463829e-05 0.000434961074717145 1.11027637639833 0.75 7.2 7 2 abnormal spongiotrophoblast layer morphology 7.2164929175127e-05 0.00108808358525859 1.11027637639833 0.75 7.2 7 2 abnormal somite shape 0.00020750530209794 0.00276026437951137 1.11027637639833 0.75 7.2 7 2 abnormal mitotic spindle morphology 0.00020750530209794 0.00276026437951137 1.11027637639833 0.75 7.2 7 2 abnormal circulating enzyme level 0.00176692545422144 0.0161292736417462 1.11027637639833 0.75 7.2 7 2 abnormal lens epithelium morphology 0.00176692545422144 0.0161292736417462 1.11027637639833 0.75 7.2 7 2 abnormal optic stalk morphology 0.00176692545422144 0.0161292736417462 1.11027637639833 0.75 7.2 7 2 abnormal response to tactile stimuli 0.00176692545422144 0.0161292736417462 1.11027637639833 0.75 7.2 7 2 abnormal neuron proliferation 0.00176692545422144 0.0161292736417462 1.11027637639833 0.75 7.2 7 2 increased skin tumor incidence 0.00176692545422144 0.0161292736417462 1.11027637639833 0.75 7.2 7 2 failure of tooth eruption 0.00527494613682421 0.0370661822467521 1.11027637639833 0.75 7.2 7 2 intraventricular hemorrhage 0.00527494613682421 0.0370661822467521 1.11027637639833 0.75 7.2 7 2 increased intestinal adenocarcinoma incidence 0.00527494613682421 0.0370661822467521 1.11027637639833 0.75 7.2 7 2 blepharitis 0.00527494613682421 0.0370661822467521 1.11027637639833 0.75 7.2 7 2 dystonia 0.00527494613682421 0.0370661822467521 1.11027637639833 0.75 7.2 7 2 impaired behavioral response to addictive substance 0.00527494613682421 0.0370661822467521 1.11027637639833 0.75 7.2 7 2 absent mammary gland 0.0517761933526764 0.20541193136329 1.11027637639833 0.75 7.2 7 2 enlarged pituitary gland 0.0517761933526764 0.20541193136329 1.11027637639833 0.75 7.2 7 2 abnormal vagus ganglion morphology 0.0517761933526764 0.20541193136329 1.11027637639833 0.75 7.2 7 2 dermal cysts 0.0517761933526764 0.20541193136329 1.11027637639833 0.75 7.2 7 2 short ureter 0.0517761933526764 0.20541193136329 1.11027637639833 0.75 7.2 7 2 increased cardiac output 0.0517761933526764 0.20541193136329 1.11027637639833 0.75 7.2 7 2 abnormal kidney epithelium morphology 0.0517761933526764 0.20541193136329 1.11027637639833 0.75 7.2 7 2 craniofacial phenotype 0.0517761933526764 0.20541193136329 1.11027637639833 0.75 7.2 7 2 stomach epithelial hyperplasia 0.0517761933526764 0.20541193136329 1.11027637639833 0.75 7.2 7 2 abnormal mitotic spindle assembly checkpoint 0.0517761933526764 0.20541193136329 1.11027637639833 0.75 7.2 7 2 abnormal olfactory bulb glomerular layer morphology 0.0517761933526764 0.20541193136329 1.11027637639833 0.75 7.2 7 2 abnormal olfactory bulb mitral cell layer morphology 0.0517761933526764 0.20541193136329 1.11027637639833 0.75 7.2 7 2 decreased hippocampus pyramidal cell number 0.0517761933526764 0.20541193136329 1.11027637639833 0.75 7.2 7 2 increased caudal vertebrae number 0.0517761933526764 0.20541193136329 1.11027637639833 0.75 7.2 7 2 pleural effusion 0.0517761933526764 0.20541193136329 1.11027637639833 0.75 7.2 7 2 myocardial trabeculae hypoplasia 0.0517761933526764 0.20541193136329 1.11027637639833 0.75 7.2 7 2 abnormal visual evoked potential 0.0517761933526764 0.20541193136329 1.11027637639833 0.75 7.2 7 2 abnormal anterior commissure pars posterior morphology 0.0517761933526764 0.20541193136329 1.11027637639833 0.75 7.2 7 2 increased airway resistance 0.0517761933526764 0.20541193136329 1.11027637639833 0.75 7.2 7 2 increased aorta wall thickness 0.0517761933526764 0.20541193136329 1.11027637639833 0.75 7.2 7 2 impaired neuron differentiation 0.0517761933526764 0.20541193136329 1.11027637639833 0.75 7.2 7 2 increased cardiac stroke volume 0.0517761933526764 0.20541193136329 1.11027637639833 0.75 7.2 7 2 prolonged PQ interval 0.0517761933526764 0.20541193136329 1.11027637639833 0.75 7.2 7 2 increased cornea thickness 0.0517761933526764 0.20541193136329 1.11027637639833 0.75 7.2 7 2 absent hypoglossal canal 0.0517761933526764 0.20541193136329 1.11027637639833 0.75 7.2 7 2 retropleural edema 0.0517761933526764 0.20541193136329 1.11027637639833 0.75 7.2 7 2 increased mammary gland apoptosis 0.0517761933526764 0.20541193136329 1.11027637639833 0.75 7.2 7 2 decreased white adipose tissue mass 0.0517761933526764 0.20541193136329 1.11027637639833 0.75 7.2 7 2 increased brain apoptosis 0.0517761933526764 0.20541193136329 1.11027637639833 0.75 7.2 7 2 decreased basal metabolism 0.0517761933526764 0.20541193136329 1.11027637639833 0.75 7.2 7 2 abnormal motor coordination/ balance 3.46884804871322e-12 2.36404370443127e-10 1.1065380721007 0.747474747474748 7.2 7 2 abnormal CNS synaptic transmission 3.46884804871322e-12 2.36404370443127e-10 1.1065380721007 0.747474747474748 7.2 7 2 abnormal placenta morphology 5.66505465343963e-10 2.93994696719833e-08 1.10559166594939 0.746835443037975 7.2 7 2 abnormal nervous system morphology 5.66505465343963e-10 2.93994696719833e-08 1.10559166594939 0.746835443037975 7.2 7 2 preweaning lethality, complete penetrance 1.30608521371983e-81 6.49777393825616e-78 1.10427488247186 0.745945945945946 7.2 7 2 decreased birth body size 1.10975414187474e-13 9.35767263699459e-12 1.10378353209191 0.745614035087719 7.2 7 2 abnormal double-strand DNA break repair 5.90158657931874e-06 0.00011935119200045 1.10166958278284 0.744186046511628 7.2 7 2 increased hepatocyte apoptosis 1.67033996077307e-05 0.000297847358596631 1.10078683471971 0.743589743589744 7.2 7 2 pale liver 2.93415254288748e-09 1.20639742982357e-07 1.10027388652087 0.743243243243243 7.2 7 2 embryonic lethality, complete penetrance 3.87579863782436e-35 1.92820982231762e-32 1.0998349057739 0.74294670846395 7.2 7 2 embryonic lethality between implantation and somite formation, complete penetrance 2.662677589046e-27 9.46201500393133e-25 1.09970231567073 0.742857142857143 7.2 7 2 abnormal erythropoiesis 1.57500287629547e-12 1.11937704422428e-10 1.09970231567073 0.742857142857143 7.2 7 2 abnormal vascular development 2.27134450412819e-08 7.73968418358751e-07 1.09906146350542 0.742424242424242 7.2 7 2 decreased thymus weight 0.000135750425575342 0.00189080688337482 1.09833792073814 0.741935483870968 7.2 7 2 abnormal embryonic neuroepithelium morphology 1.76835676293712e-07 4.97038129695603e-06 1.09751457896847 0.741379310344828 7.2 7 2 abnormal trigeminal nerve morphology 0.000390794234012567 0.00467356085147241 1.09656926064033 0.740740740740741 7.2 7 2 abnormal skin appearance 0.000390794234012567 0.00467356085147241 1.09656926064033 0.740740740740741 7.2 7 2 microcephaly 1.51399954407473e-08 5.30432938857168e-07 1.09418541442155 0.739130434782609 7.2 7 2 abnormal vertebral artery topology 0.00113533613956184 0.0114338001909315 1.09418541442155 0.739130434782609 7.2 7 2 abnormal reproductive system morphology 1.0996237931477e-05 0.000207220771625371 1.09265294185233 0.738095238095238 7.2 7 2 embryonic growth arrest 6.5452606559661e-25 1.80903732019063e-22 1.09249902539341 0.737991266375546 7.2 7 2 decreased circulating serum albumin level 1.4902083947605e-11 9.50485482555578e-10 1.09158485491015 0.737373737373737 7.2 7 2 kyphoscoliosis 0.00333953323805292 0.0263717108877988 1.09079784347906 0.736842105263158 7.2 7 2 abnormal triglyceride level 0.00333953323805292 0.0263717108877988 1.09079784347906 0.736842105263158 7.2 7 2 small superior vagus ganglion 0.00333953323805292 0.0263717108877988 1.09079784347906 0.736842105263158 7.2 7 2 abnormal optic vesicle formation 0.00333953323805292 0.0263717108877988 1.09079784347906 0.736842105263158 7.2 7 2 abnormal blastocyst morphology 0.00333953323805292 0.0263717108877988 1.09079784347906 0.736842105263158 7.2 7 2 increased liver cholesterol level 0.00333953323805292 0.0263717108877988 1.09079784347906 0.736842105263158 7.2 7 2 embryonic lethality between implantation and somite formation, incomplete penetrance 0.00333953323805292 0.0263717108877988 1.09079784347906 0.736842105263158 7.2 7 2 hydrops fetalis 1.00649548496671e-08 3.60238491921538e-07 1.08971570276133 0.736111111111111 7.2 7 2 abnormal neural tube closure 8.70294593065414e-10 4.10740764521001e-08 1.08798167004495 0.734939759036145 7.2 7 2 increased circulating LDL cholesterol level 2.56858194961768e-06 5.75616900871529e-05 1.08761767483918 0.73469387755102 7.2 7 2 abnormal embryo size 8.71821955172799e-13 6.47360332385772e-11 1.08735031552875 0.734513274336283 7.2 7 2 abnormal placenta labyrinth morphology 2.40945440879976e-09 1.03336514515335e-07 1.08685282415364 0.734177215189873 7.2 7 2 abnormal eye morphology 2.45646416782153e-15 2.65671939889393e-13 1.08631357690772 0.733812949640288 7.2 7 2 disorganized myocardium 0.000252846548414257 0.00327581140198158 1.08560356803393 0.733333333333333 7.2 7 2 absent egg cylinders 0.00999881214141499 0.0607375951203169 1.08560356803393 0.733333333333333 7.2 7 2 abnormal lymph node B cell domain morphology 0.00999881214141499 0.0607375951203169 1.08560356803393 0.733333333333333 7.2 7 2 decreased aggression towards males 0.00999881214141499 0.0607375951203169 1.08560356803393 0.733333333333333 7.2 7 2 abnormal placenta size 0.00999881214141499 0.0607375951203169 1.08560356803393 0.733333333333333 7.2 7 2 abnormal olfactory nerve morphology 0.00999881214141499 0.0607375951203169 1.08560356803393 0.733333333333333 7.2 7 2 abnormal dendritic cell morphology 0.00999881214141499 0.0607375951203169 1.08560356803393 0.733333333333333 7.2 7 2 decreased brown adipose tissue mass 0.00999881214141499 0.0607375951203169 1.08560356803393 0.733333333333333 7.2 7 2 impaired coordination 1.84049800993896e-35 1.01738639993848e-32 1.08246598546735 0.73121387283237 7.2 7 2 abnormal nasal bone morphology 0.000727752897507043 0.00778617347332804 1.08180775136248 0.730769230769231 7.2 7 2 decreased circulating glycerol level 0.000727752897507043 0.00778617347332804 1.08180775136248 0.730769230769231 7.2 7 2 abnormal excitatory postsynaptic currents 4.41876512940755e-09 1.7586685215042e-07 1.08180775136248 0.730769230769231 7.2 7 2 anophthalmia 3.82986722607728e-10 2.09380103843236e-08 1.08116800697965 0.730337078651685 7.2 7 2 gliosis 1.42753739577455e-07 4.17764620234022e-06 1.08090398548832 0.73015873015873 7.2 7 2 vertebral transformation 4.72374423431073e-06 9.76512957822571e-05 1.07943536594282 0.729166666666667 7.2 7 2 abnormal germ layer development 0.00211371672399987 0.0185462798975297 1.0766316377196 0.727272727272727 7.2 7 2 intracerebral hemorrhage 0.00211371672399987 0.0185462798975297 1.0766316377196 0.727272727272727 7.2 7 2 increased myocardial infarction size 0.00211371672399987 0.0185462798975297 1.0766316377196 0.727272727272727 7.2 7 2 abnormal limb posture 0.00211371672399987 0.0185462798975297 1.0766316377196 0.727272727272727 7.2 7 2 abnormal blood-brain barrier function 0.00211371672399987 0.0185462798975297 1.0766316377196 0.727272727272727 7.2 7 2 increased adenoma incidence 0.00211371672399987 0.0185462798975297 1.0766316377196 0.727272727272727 7.2 7 2 abnormal sphenoid bone morphology 0.030768669997887 0.138278349809835 1.0766316377196 0.727272727272727 7.2 7 2 abnormal sebaceous gland morphology 0.030768669997887 0.138278349809835 1.0766316377196 0.727272727272727 7.2 7 2 abnormal glossopharyngeal ganglion morphology 0.030768669997887 0.138278349809835 1.0766316377196 0.727272727272727 7.2 7 2 abnormal eye distance/ position 0.030768669997887 0.138278349809835 1.0766316377196 0.727272727272727 7.2 7 2 abnormal food preference 0.030768669997887 0.138278349809835 1.0766316377196 0.727272727272727 7.2 7 2 impaired myelopoiesis 0.030768669997887 0.138278349809835 1.0766316377196 0.727272727272727 7.2 7 2 abnormal proximal-distal axis patterning 0.030768669997887 0.138278349809835 1.0766316377196 0.727272727272727 7.2 7 2 abnormal hypothalamus secretion 0.030768669997887 0.138278349809835 1.0766316377196 0.727272727272727 7.2 7 2 fused joints 0.030768669997887 0.138278349809835 1.0766316377196 0.727272727272727 7.2 7 2 loss of cortex neurons 0.030768669997887 0.138278349809835 1.0766316377196 0.727272727272727 7.2 7 2 pharyngeal arch hypoplasia 0.030768669997887 0.138278349809835 1.0766316377196 0.727272727272727 7.2 7 2 cyclopia 0.030768669997887 0.138278349809835 1.0766316377196 0.727272727272727 7.2 7 2 aorta dilation 0.030768669997887 0.138278349809835 1.0766316377196 0.727272727272727 7.2 7 2 abnormal pulmonary alveolar sac morphology 0.030768669997887 0.138278349809835 1.0766316377196 0.727272727272727 7.2 7 2 increased insulin sensitivity 3.62196405220128e-15 3.83388748078753e-13 1.0766316377196 0.727272727272727 7.2 7 2 increased osteoblast cell number 0.000163246022619508 0.00223732496565304 1.0766316377196 0.727272727272727 7.2 7 2 abnormal response to novel object 3.08625145404563e-06 6.70484759121267e-05 1.07399283468597 0.725490196078431 7.2 7 2 embryonic lethality during organogenesis, complete penetrance 1.51112354399301e-54 1.25297327189421e-51 1.07326716385172 0.725 7.2 7 2 increased mortality induced by gamma-irradiation 0.000465975897479498 0.00542911028093794 1.07199098410874 0.724137931034483 7.2 7 2 absent long term depression 0.000465975897479498 0.00542911028093794 1.07199098410874 0.724137931034483 7.2 7 2 abnormal neural tube morphology 1.67871118718849e-16 2.25718598817911e-14 1.06915502912432 0.722222222222222 7.2 7 2 oxidative stress 8.34994421996056e-10 3.99432427829844e-08 1.06915502912432 0.722222222222222 7.2 7 2 abnormal forebrain development 4.04711781301327e-08 1.33340470991662e-06 1.06915502912432 0.722222222222222 7.2 7 2 lowered ear position 0.00621481726042165 0.0418385871050037 1.06915502912432 0.722222222222222 7.2 7 2 abnormal megakaryocyte differentiation 0.00621481726042165 0.0418385871050037 1.06915502912432 0.722222222222222 7.2 7 2 abnormal mitral valve morphology 0.00621481726042165 0.0418385871050037 1.06915502912432 0.722222222222222 7.2 7 2 underdeveloped hair follicles 0.00621481726042165 0.0418385871050037 1.06915502912432 0.722222222222222 7.2 7 2 abnormal thymus medulla morphology 0.00621481726042165 0.0418385871050037 1.06915502912432 0.722222222222222 7.2 7 2 abnormal anterior eye segment morphology 0.00621481726042165 0.0418385871050037 1.06915502912432 0.722222222222222 7.2 7 2 atrioventricular block 0.00621481726042165 0.0418385871050037 1.06915502912432 0.722222222222222 7.2 7 2 abnormal aerobic respiration 0.00621481726042165 0.0418385871050037 1.06915502912432 0.722222222222222 7.2 7 2 increased adipocyte glucose uptake 0.00621481726042165 0.0418385871050037 1.06915502912432 0.722222222222222 7.2 7 2 decreased mean corpuscular hemoglobin 1.11772772678733e-07 3.30993776236128e-06 1.0667361263435 0.720588235294118 7.2 7 2 spontaneous skin ulceration 0.00133885256897635 0.0132685090252138 1.0658653213424 0.72 7.2 7 2 increased liver glycogen level 0.00133885256897635 0.0132685090252138 1.0658653213424 0.72 7.2 7 2 limb grasping 4.27078769337026e-18 6.85392541113453e-16 1.0655399656277 0.71978021978022 7.2 7 2 increased startle reflex 1.50644815717794e-09 6.81325416541842e-08 1.06453465302612 0.719101123595506 7.2 7 2 abnormal depression-related behavior 0.000298246694153668 0.00375639823649241 1.06401486071507 0.71875 7.2 7 2 abnormal spatial learning 3.58629476233502e-16 4.38000187191461e-14 1.06259579581681 0.717791411042945 7.2 7 2 thymus hypoplasia 6.95882474820374e-14 6.0737110740901e-12 1.06200349046797 0.717391304347826 7.2 7 2 absent mesoderm 8.5382778411539e-07 2.07209425657271e-05 1.06093075966952 0.716666666666667 7.2 7 2 increased exploration in new environment 1.13483952745501e-08 4.03273332077764e-07 1.06001695195232 0.716049382716049 7.2 7 2 small spleen 1.77015406197223e-09 7.79337739673614e-08 1.05740607276032 0.714285714285714 7.2 7 2 increased grip strength 1.77015406197223e-09 7.79337739673614e-08 1.05740607276032 0.714285714285714 7.2 7 2 decreased susceptibility to hepatic steatosis 5.55311379084547e-07 1.40237264515006e-05 1.05740607276032 0.714285714285714 7.2 7 2 increased circulating aspartate transaminase level 5.55311379084547e-07 1.40237264515006e-05 1.05740607276032 0.714285714285714 7.2 7 2 myoclonus 0.000849016563799143 0.00891109157152054 1.05740607276032 0.714285714285714 7.2 7 2 straub tail 0.000849016563799143 0.00891109157152054 1.05740607276032 0.714285714285714 7.2 7 2 premature aging 0.000849016563799143 0.00891109157152054 1.05740607276032 0.714285714285714 7.2 7 2 abnormal hormone level 0.000849016563799143 0.00891109157152054 1.05740607276032 0.714285714285714 7.2 7 2 abnormal salivary gland morphology 0.00387941367099916 0.0294657755927035 1.05740607276032 0.714285714285714 7.2 7 2 midline facial cleft 0.0185937112699551 0.0993595204812315 1.05740607276032 0.714285714285714 7.2 7 2 translucent skin 0.0185937112699551 0.0993595204812315 1.05740607276032 0.714285714285714 7.2 7 2 abnormal fluid regulation 0.0185937112699551 0.0993595204812315 1.05740607276032 0.714285714285714 7.2 7 2 failure of zygotic cell division 0.0185937112699551 0.0993595204812315 1.05740607276032 0.714285714285714 7.2 7 2 abnormal vascular endothelial cell migration 0.0185937112699551 0.0993595204812315 1.05740607276032 0.714285714285714 7.2 7 2 decreased CNS synapse formation 0.0185937112699551 0.0993595204812315 1.05740607276032 0.714285714285714 7.2 7 2 abnormal viscerocranium morphology 0.0185937112699551 0.0993595204812315 1.05740607276032 0.714285714285714 7.2 7 2 increased pulmonary respiratory rate 0.0185937112699551 0.0993595204812315 1.05740607276032 0.714285714285714 7.2 7 2 cellular necrosis 0.0993289502299009 0.308003207733853 1.05740607276032 0.714285714285714 7.2 7 2 broad head 0.0993289502299009 0.308003207733853 1.05740607276032 0.714285714285714 7.2 7 2 absent hair follicles 0.0993289502299009 0.308003207733853 1.05740607276032 0.714285714285714 7.2 7 2 polyphalangy 0.0993289502299009 0.308003207733853 1.05740607276032 0.714285714285714 7.2 7 2 mammary gland hyperplasia 0.0993289502299009 0.308003207733853 1.05740607276032 0.714285714285714 7.2 7 2 abnormal oculomotor nerve morphology 0.0993289502299009 0.308003207733853 1.05740607276032 0.714285714285714 7.2 7 2 absent epidermis stratum corneum 0.0993289502299009 0.308003207733853 1.05740607276032 0.714285714285714 7.2 7 2 abnormal lacrimal gland morphology 0.0993289502299009 0.308003207733853 1.05740607276032 0.714285714285714 7.2 7 2 abnormal axial mesoderm 0.0993289502299009 0.308003207733853 1.05740607276032 0.714285714285714 7.2 7 2 abnormal melanocyte morphology 0.0993289502299009 0.308003207733853 1.05740607276032 0.714285714285714 7.2 7 2 increased retinal ganglion cell number 0.0993289502299009 0.308003207733853 1.05740607276032 0.714285714285714 7.2 7 2 decreased mortality induced by ionizing radiation 0.0993289502299009 0.308003207733853 1.05740607276032 0.714285714285714 7.2 7 2 increased cell nucleus count 0.0993289502299009 0.308003207733853 1.05740607276032 0.714285714285714 7.2 7 2 abnormal organ of Corti supporting cell morphology 0.0993289502299009 0.308003207733853 1.05740607276032 0.714285714285714 7.2 7 2 absent ulna 0.0993289502299009 0.308003207733853 1.05740607276032 0.714285714285714 7.2 7 2 abnormal cochlear nerve compound action potential 0.0993289502299009 0.308003207733853 1.05740607276032 0.714285714285714 7.2 7 2 abnormal talus morphology 0.0993289502299009 0.308003207733853 1.05740607276032 0.714285714285714 7.2 7 2 decreased adrenocorticotropin level 0.0993289502299009 0.308003207733853 1.05740607276032 0.714285714285714 7.2 7 2 abnormal renal/urinary system physiology 0.0993289502299009 0.308003207733853 1.05740607276032 0.714285714285714 7.2 7 2 abnormal renal filtration rate 0.0993289502299009 0.308003207733853 1.05740607276032 0.714285714285714 7.2 7 2 decreased tidal volume 0.0993289502299009 0.308003207733853 1.05740607276032 0.714285714285714 7.2 7 2 abnormal spinal cord central canal morphology 0.0993289502299009 0.308003207733853 1.05740607276032 0.714285714285714 7.2 7 2 decreased behavioral withdrawal response 0.0993289502299009 0.308003207733853 1.05740607276032 0.714285714285714 7.2 7 2 decreased brain cholesterol level 0.0993289502299009 0.308003207733853 1.05740607276032 0.714285714285714 7.2 7 2 focal dorsal hair loss 0.0993289502299009 0.308003207733853 1.05740607276032 0.714285714285714 7.2 7 2 abnormal retina inner limiting membrane morphology 0.0993289502299009 0.308003207733853 1.05740607276032 0.714285714285714 7.2 7 2 abnormal T wave 0.0993289502299009 0.308003207733853 1.05740607276032 0.714285714285714 7.2 7 2 long stride length 0.0993289502299009 0.308003207733853 1.05740607276032 0.714285714285714 7.2 7 2 embryonic lethality at implantation, incomplete penetrance 0.0993289502299009 0.308003207733853 1.05740607276032 0.714285714285714 7.2 7 2 increased circulating lactate dehydrogenase level 0.0993289502299009 0.308003207733853 1.05740607276032 0.714285714285714 7.2 7 2 small tail bud 0.0993289502299009 0.308003207733853 1.05740607276032 0.714285714285714 7.2 7 2 absent heart tube 0.0993289502299009 0.308003207733853 1.05740607276032 0.714285714285714 7.2 7 2 absent connection between subcutaneous lymph vessels and lymph sac 0.0993289502299009 0.308003207733853 1.05740607276032 0.714285714285714 7.2 7 2 decreased triglyceride level 0.000190896369002632 0.00256528012502196 1.05740607276032 0.714285714285714 7.2 7 2 decreased glycogen level 0.000190896369002632 0.00256528012502196 1.05740607276032 0.714285714285714 7.2 7 2 astrocytosis 8.54588658116472e-08 2.62443121859843e-06 1.05450906982125 0.712328767123288 7.2 7 2 thin ventricular wall 3.15925735147181e-09 1.28830371504691e-07 1.05270649021472 0.711111111111111 7.2 7 2 trabecula carnea hypoplasia 2.81178152311861e-05 0.000470997073317006 1.05270649021472 0.711111111111111 7.2 7 2 persistence of hyaloid vascular system 0.00012221676137878 0.0017175943159871 1.05184077764053 0.710526315789474 7.2 7 2 increased grooming behavior 0.00012221676137878 0.0017175943159871 1.05184077764053 0.710526315789474 7.2 7 2 osteopetrosis 0.000539081515353828 0.00610918118197105 1.05058409809735 0.709677419354839 7.2 7 2 abnormal eyelid morphology 0.000539081515353828 0.00610918118197105 1.05058409809735 0.709677419354839 7.2 7 2 inner cell mass degeneration 0.000539081515353828 0.00610918118197105 1.05058409809735 0.709677419354839 7.2 7 2 abnormal embryo turning 4.22435743319256e-06 8.9051602670055e-05 1.04971584677661 0.709090909090909 7.2 7 2 oligodactyly 1.81020843274471e-05 0.000320490638893414 1.04859435548731 0.708333333333333 7.2 7 2 thymus atrophy 1.81020843274471e-05 0.000320490638893414 1.04859435548731 0.708333333333333 7.2 7 2 abnormal body weight 0.00243074720949313 0.0207560056992116 1.04859435548731 0.708333333333333 7.2 7 2 ocular hypertelorism 0.00243074720949313 0.0207560056992116 1.04859435548731 0.708333333333333 7.2 7 2 abnormal nursing 0.00243074720949313 0.0207560056992116 1.04859435548731 0.708333333333333 7.2 7 2 abnormal sensory capabilities/reflexes/nociception 0.00243074720949313 0.0207560056992116 1.04859435548731 0.708333333333333 7.2 7 2 prolonged QT interval 0.00243074720949313 0.0207560056992116 1.04859435548731 0.708333333333333 7.2 7 2 abnormal tumor morphology 0.00243074720949313 0.0207560056992116 1.04859435548731 0.708333333333333 7.2 7 2 increased hemangiosarcoma incidence 0.00243074720949313 0.0207560056992116 1.04859435548731 0.708333333333333 7.2 7 2 abnormal brain morphology 4.23462859479603e-15 4.38901609564796e-13 1.04821123734501 0.708074534161491 7.2 7 2 abnormal muscle physiology 5.6141901205196e-09 2.11595423102917e-07 1.04790129907258 0.707865168539326 7.2 7 2 abnormal neuron morphology 8.75146151542234e-10 4.10740764521001e-08 1.0467252033385 0.707070707070707 7.2 7 2 decreased erythrocyte cell number 1.14591063181421e-14 1.1178245869168e-12 1.0466299599169 0.707006369426752 7.2 7 2 abnormal embryo development 8.13856051199413e-13 6.13474826472285e-11 1.04496600131608 0.705882352941177 7.2 7 2 abnormal trophoblast layer morphology 1.16543999143298e-05 0.000217155953459891 1.04496600131608 0.705882352941177 7.2 7 2 failure of chorioallantoic fusion 1.16543999143298e-05 0.000217155953459891 1.04496600131608 0.705882352941177 7.2 7 2 lung hemorrhage 0.000342729875504358 0.0042106887205158 1.04496600131608 0.705882352941177 7.2 7 2 abnormal endoderm development 0.000342729875504358 0.0042106887205158 1.04496600131608 0.705882352941177 7.2 7 2 impaired synaptic plasticity 0.000342729875504358 0.0042106887205158 1.04496600131608 0.705882352941177 7.2 7 2 abnormal dorsal-ventral axis patterning 0.0113673234230092 0.0670052535894201 1.04496600131608 0.705882352941177 7.2 7 2 abnormal touch/ nociception 0.0113673234230092 0.0670052535894201 1.04496600131608 0.705882352941177 7.2 7 2 abnormal duodenum morphology 0.0113673234230092 0.0670052535894201 1.04496600131608 0.705882352941177 7.2 7 2 abnormal involuntary movement 0.0113673234230092 0.0670052535894201 1.04496600131608 0.705882352941177 7.2 7 2 abnormal ectoplacental cone morphology 0.0113673234230092 0.0670052535894201 1.04496600131608 0.705882352941177 7.2 7 2 abnormal tarsal bone morphology 0.0113673234230092 0.0670052535894201 1.04496600131608 0.705882352941177 7.2 7 2 coloboma 0.0113673234230092 0.0670052535894201 1.04496600131608 0.705882352941177 7.2 7 2 abnormal survival 0.0113673234230092 0.0670052535894201 1.04496600131608 0.705882352941177 7.2 7 2 abnormal behavior 1.57574745393143e-24 3.91967179165443e-22 1.04371304447997 0.705035971223022 7.2 7 2 embryonic lethality, incomplete penetrance 5.01570410686704e-05 0.00079468560291922 1.04298689904086 0.704545454545455 7.2 7 2 abnormal nervous system physiology 5.81185590799928e-11 3.5260955051581e-09 1.04269433609583 0.704347826086957 7.2 7 2 lethality throughout fetal growth and development, incomplete penetrance 3.29394896633205e-16 4.20189643782101e-14 1.04204710187106 0.70391061452514 7.2 7 2 abnormal atrioventricular cushion morphology 0.00152802972330642 0.0146191305258643 1.04174079760831 0.703703703703704 7.2 7 2 decreased susceptibility to pharmacologically induced seizures 0.00152802972330642 0.0146191305258643 1.04174079760831 0.703703703703704 7.2 7 2 decreased grip strength 2.05554019237871e-19 3.65225444895861e-17 1.04098972277226 0.703196347031963 7.2 7 2 pallor 8.87866594031545e-16 9.81585845623764e-14 1.04048757559615 0.702857142857143 7.2 7 2 abnormal calcium ion homeostasis 0.000218166782563209 0.0028866482533297 1.0402589472561 0.702702702702703 7.2 7 2 prenatal lethality, complete penetrance 5.60274501973075e-24 1.3273169749124e-21 1.0383879779265 0.701438848920863 7.2 7 2 enlarged liver 1.76597096083494e-09 7.79337739673614e-08 1.03625795130511 0.7 7.2 7 2 abnormal action potential 4.75300038597068e-07 1.23157171459396e-05 1.03625795130511 0.7 7.2 7 2 abnormal heart tube morphology 0.00096327771196506 0.00998397211880453 1.03625795130511 0.7 7.2 7 2 increased mammary adenocarcinoma incidence 0.00700895140032635 0.0461848122074485 1.03625795130511 0.7 7.2 7 2 abnormal dopamine level 0.00700895140032635 0.0461848122074485 1.03625795130511 0.7 7.2 7 2 abnormal hearing physiology 0.00700895140032635 0.0461848122074485 1.03625795130511 0.7 7.2 7 2 abnormal postnatal subventricular zone morphology 0.00700895140032635 0.0461848122074485 1.03625795130511 0.7 7.2 7 2 abnormal sperm mitochondrial sheath morphology 0.00700895140032635 0.0461848122074485 1.03625795130511 0.7 7.2 7 2 enlarged testis 0.0571253588367233 0.218951202012865 1.03625795130511 0.7 7.2 7 2 abnormal epidermis suprabasal layer morphology 0.0571253588367233 0.218951202012865 1.03625795130511 0.7 7.2 7 2 fused cornea and lens 0.0571253588367233 0.218951202012865 1.03625795130511 0.7 7.2 7 2 abnormal grooming behavior 0.0571253588367233 0.218951202012865 1.03625795130511 0.7 7.2 7 2 abnormal gland morphology 0.0571253588367233 0.218951202012865 1.03625795130511 0.7 7.2 7 2 impaired social transmission of food preference 0.0571253588367233 0.218951202012865 1.03625795130511 0.7 7.2 7 2 abnormal tibialis anterior morphology 0.0571253588367233 0.218951202012865 1.03625795130511 0.7 7.2 7 2 increased atrioventricular cushion size 0.0571253588367233 0.218951202012865 1.03625795130511 0.7 7.2 7 2 abnormal gas homeostasis 0.0571253588367233 0.218951202012865 1.03625795130511 0.7 7.2 7 2 abnormal plasma membrane morphology 0.0571253588367233 0.218951202012865 1.03625795130511 0.7 7.2 7 2 abnormal embryonic erythrocyte morphology 0.0571253588367233 0.218951202012865 1.03625795130511 0.7 7.2 7 2 abnormal respiratory conducting tube morphology 0.0571253588367233 0.218951202012865 1.03625795130511 0.7 7.2 7 2 increased susceptibility to atherosclerosis 0.0571253588367233 0.218951202012865 1.03625795130511 0.7 7.2 7 2 tachypnea 0.0571253588367233 0.218951202012865 1.03625795130511 0.7 7.2 7 2 absent inguinal lymph nodes 0.0571253588367233 0.218951202012865 1.03625795130511 0.7 7.2 7 2 absent axillary lymph nodes 0.0571253588367233 0.218951202012865 1.03625795130511 0.7 7.2 7 2 ventricular premature beat 0.0571253588367233 0.218951202012865 1.03625795130511 0.7 7.2 7 2 abnormal sperm principal piece morphology 0.0571253588367233 0.218951202012865 1.03625795130511 0.7 7.2 7 2 decreased transitional stage T2 B cell number 0.0571253588367233 0.218951202012865 1.03625795130511 0.7 7.2 7 2 abnormal cerebellar granule cell migration 0.0571253588367233 0.218951202012865 1.03625795130511 0.7 7.2 7 2 increased serotonin level 0.0571253588367233 0.218951202012865 1.03625795130511 0.7 7.2 7 2 increased circulating fructosamine level 0.0571253588367233 0.218951202012865 1.03625795130511 0.7 7.2 7 2 aorta stenosis 0.0571253588367233 0.218951202012865 1.03625795130511 0.7 7.2 7 2 abnormal inferior vena cava valve morphology 0.0571253588367233 0.218951202012865 1.03625795130511 0.7 7.2 7 2 thick aortic valve cusps 0.0571253588367233 0.218951202012865 1.03625795130511 0.7 7.2 7 2 decreased trabecular bone connectivity density 0.0571253588367233 0.218951202012865 1.03625795130511 0.7 7.2 7 2 abnormal circadian temperature homeostasis 0.0571253588367233 0.218951202012865 1.03625795130511 0.7 7.2 7 2 decreased macrophage apoptosis 0.0571253588367233 0.218951202012865 1.03625795130511 0.7 7.2 7 2 decreased circulating lactate level 0.0571253588367233 0.218951202012865 1.03625795130511 0.7 7.2 7 2 increased fatty acid oxidation 0.0571253588367233 0.218951202012865 1.03625795130511 0.7 7.2 7 2 seminiferous tubule degeneration 3.07041371470548e-07 8.34716296757365e-06 1.03423004924776 0.698630136986301 7.2 7 2 abnormal mesoderm development 1.32349740732762e-05 0.000244773219384941 1.03346480318839 0.69811320754717 7.2 7 2 increased circulating bilirubin level 1.32349740732762e-05 0.000244773219384941 1.03346480318839 0.69811320754717 7.2 7 2 retinal degeneration 4.76644809784173e-09 1.86788056368882e-07 1.03317385025956 0.697916666666667 7.2 7 2 increased oxygen consumption 3.06671201646273e-08 1.03087110012852e-06 1.03281523385891 0.697674418604651 7.2 7 2 abnormal axon guidance 8.8705903143907e-05 0.00128662352227678 1.03281523385891 0.697674418604651 7.2 7 2 increased circulating alkaline phosphatase level 3.02026574789585e-14 2.73196765377852e-12 1.03260272043631 0.697530864197531 7.2 7 2 abnormal eye development 8.49730539158346e-06 0.000166433442217038 1.03097092094131 0.696428571428571 7.2 7 2 abnormal cell death 5.66513514083039e-05 0.000874046460068958 1.0298215665144 0.695652173913043 7.2 7 2 abnormal allantois morphology 5.66513514083039e-05 0.000874046460068958 1.0298215665144 0.695652173913043 7.2 7 2 atrial septal defect 5.66513514083039e-05 0.000874046460068958 1.0298215665144 0.695652173913043 7.2 7 2 hypotension 0.00435001520271538 0.0312284641176176 1.0298215665144 0.695652173913043 7.2 7 2 abnormal Wolffian duct morphology 0.00435001520271538 0.0312284641176176 1.0298215665144 0.695652173913043 7.2 7 2 abnormal B cell morphology 0.00435001520271538 0.0312284641176176 1.0298215665144 0.695652173913043 7.2 7 2 abnormal hematopoietic stem cell physiology 0.00435001520271538 0.0312284641176176 1.0298215665144 0.695652173913043 7.2 7 2 abnormal excitatory postsynaptic potential 8.28020189503374e-08 2.57462527673705e-06 1.02903664153992 0.695121951219512 7.2 7 2 lethality throughout fetal growth and development, complete penetrance 3.60964978388943e-16 4.38000187191461e-14 1.0284665381374 0.694736842105263 7.2 7 2 cataract 8.54753624841675e-11 4.94465032975271e-09 1.02769383600507 0.694214876033058 7.2 7 2 abnormal lung development 5.35042922020491e-08 1.71964036838939e-06 1.02754990129414 0.694117647058824 7.2 7 2 abnormal hepatocyte morphology 5.44940792144823e-10 2.9151402590543e-08 1.02692229408615 0.693693693693694 7.2 7 2 kyphosis 5.79188326713464e-13 4.43301834676843e-11 1.02638882795935 0.693333333333333 7.2 7 2 abnormal brain wave pattern 2.31691536771811e-05 0.000401625573323958 1.02487050129077 0.692307692307692 7.2 7 2 abnormal ureter morphology 0.00271382682978228 0.0226531685875283 1.02487050129077 0.692307692307692 7.2 7 2 thick skin 0.00271382682978228 0.0226531685875283 1.02487050129077 0.692307692307692 7.2 7 2 abnormal erythrocyte osmotic lysis 0.00271382682978228 0.0226531685875283 1.02487050129077 0.692307692307692 7.2 7 2 abnormal Mullerian duct morphology 0.00271382682978228 0.0226531685875283 1.02487050129077 0.692307692307692 7.2 7 2 abnormal renal/urinary system morphology 0.0338249620250449 0.14931604798101 1.02487050129077 0.692307692307692 7.2 7 2 increased foot pad pigmentation 0.0338249620250449 0.14931604798101 1.02487050129077 0.692307692307692 7.2 7 2 lymphoid hypoplasia 0.0338249620250449 0.14931604798101 1.02487050129077 0.692307692307692 7.2 7 2 abnormal retinal inner plexiform layer morphology 0.0338249620250449 0.14931604798101 1.02487050129077 0.692307692307692 7.2 7 2 increased cochlear inner hair cell number 0.0338249620250449 0.14931604798101 1.02487050129077 0.692307692307692 7.2 7 2 abnormal exocrine pancreas morphology 0.0338249620250449 0.14931604798101 1.02487050129077 0.692307692307692 7.2 7 2 abnormal aorta tunica media morphology 0.0338249620250449 0.14931604798101 1.02487050129077 0.692307692307692 7.2 7 2 decreased cardiac stroke volume 0.0338249620250449 0.14931604798101 1.02487050129077 0.692307692307692 7.2 7 2 absent hypoglossal nerve 0.0338249620250449 0.14931604798101 1.02487050129077 0.692307692307692 7.2 7 2 decreased startle reflex 2.28808796294997e-10 1.26480417951956e-08 1.02487050129077 0.692307692307692 7.2 7 2 small lens 0.000244619627088239 0.00318581844179055 1.02487050129077 0.692307692307692 7.2 7 2 impaired macrophage chemotaxis 0.000244619627088239 0.00318581844179055 1.02487050129077 0.692307692307692 7.2 7 2 pericardial edema 1.45030436153598e-06 3.37161878441191e-05 1.02319587628866 0.691176470588235 7.2 7 2 abnormal pancreas morphology 0.000155471320479324 0.00214257567696575 1.02215920366831 0.69047619047619 7.2 7 2 decreased double-positive T cell number 6.03523504872214e-09 2.24069360950691e-07 1.02145426628647 0.69 7.2 7 2 blood in lymph vessels 0.00170021804450945 0.0159295381759595 1.02094379438927 0.689655172413793 7.2 7 2 preweaning lethality, incomplete penetrance 5.46587656247562e-32 2.26606132485968e-29 1.02069417487964 0.689486552567237 7.2 7 2 lethality at weaning, complete penetrance 9.89581839945282e-05 0.00143115396910691 1.01980941239551 0.688888888888889 7.2 7 2 extramedullary hematopoiesis 2.52277965291153e-09 1.0636295570538e-07 1.01949906260476 0.688679245283019 7.2 7 2 increased sacral vertebrae number 3.91064403256714e-06 8.27891662213682e-05 1.01775334503181 0.6875 7.2 7 2 neonatal lethality 0.00106891812199418 0.0107867498111988 1.01775334503181 0.6875 7.2 7 2 absent mandible 0.0203913173515147 0.105783945593103 1.01775334503181 0.6875 7.2 7 2 disorganized retinal layers 0.0203913173515147 0.105783945593103 1.01775334503181 0.6875 7.2 7 2 impaired muscle relaxation 0.0203913173515147 0.105783945593103 1.01775334503181 0.6875 7.2 7 2 decreased aggression towards mice 0.0203913173515147 0.105783945593103 1.01775334503181 0.6875 7.2 7 2 increased cochlear outer hair cell number 0.0203913173515147 0.105783945593103 1.01775334503181 0.6875 7.2 7 2 abnormal testis morphology 6.82207439285259e-10 3.33553270618918e-08 1.01694879693297 0.68695652173913 7.2 7 2 pale yolk sac 1.60460159281897e-07 4.6412168164386e-06 1.01663860971414 0.686746987951807 7.2 7 2 impaired balance 6.7238098161795e-09 2.44167546244475e-07 1.01593916794619 0.686274509803922 7.2 7 2 abnormal cued conditioning behavior 4.0245460917779e-05 0.000654317542699185 1.01593916794619 0.686274509803922 7.2 7 2 abnormal gastrulation 4.0245460917779e-05 0.000654317542699185 1.01593916794619 0.686274509803922 7.2 7 2 abnormal artery morphology 0.000674002980599034 0.00731728934807907 1.0151098298499 0.685714285714286 7.2 7 2 increased circulating serum albumin level 0.000674002980599034 0.00731728934807907 1.0151098298499 0.685714285714286 7.2 7 2 abnormal hippocampus pyramidal cell morphology 0.000674002980599034 0.00731728934807907 1.0151098298499 0.685714285714286 7.2 7 2 decreased bone volume 0.000674002980599034 0.00731728934807907 1.0151098298499 0.685714285714286 7.2 7 2 increased cell proliferation 2.57081528133295e-05 0.000438007055638063 1.0143265660923 0.685185185185185 7.2 7 2 abnormal maxilla morphology 2.57081528133295e-05 0.000438007055638063 1.0143265660923 0.685185185185185 7.2 7 2 abnormal neuronal precursor proliferation 2.57081528133295e-05 0.000438007055638063 1.0143265660923 0.685185185185185 7.2 7 2 hypoactivity 1.37247988626477e-28 5.2523749493594e-26 1.01309038058628 0.684350132625995 7.2 7 2 incomplete somite formation 0.000426058495129471 0.00505880910088095 1.01288371180199 0.684210526315789 7.2 7 2 abnormal stationary movement 0.0124445993088873 0.0723269644412549 1.01288371180199 0.684210526315789 7.2 7 2 delayed sexual maturation 0.0124445993088873 0.0723269644412549 1.01288371180199 0.684210526315789 7.2 7 2 decreased tumor incidence 0.0124445993088873 0.0723269644412549 1.01288371180199 0.684210526315789 7.2 7 2 abnormal metatarsal bone morphology 0.0124445993088873 0.0723269644412549 1.01288371180199 0.684210526315789 7.2 7 2 increased liver adenoma incidence 0.0124445993088873 0.0723269644412549 1.01288371180199 0.684210526315789 7.2 7 2 oliguria 0.0124445993088873 0.0723269644412549 1.01288371180199 0.684210526315789 7.2 7 2 abnormal sternebra morphology 0.0124445993088873 0.0723269644412549 1.01288371180199 0.684210526315789 7.2 7 2 increased circulating VLDL cholesterol level 0.0124445993088873 0.0723269644412549 1.01288371180199 0.684210526315789 7.2 7 2 abnormal behavioral response to xenobiotic 0.0124445993088873 0.0723269644412549 1.01288371180199 0.684210526315789 7.2 7 2 decreased circulating magnesium level 0.0124445993088873 0.0723269644412549 1.01288371180199 0.684210526315789 7.2 7 2 shortened RR interval 0.0124445993088873 0.0723269644412549 1.01288371180199 0.684210526315789 7.2 7 2 abnormal somite development 4.28536738032839e-07 1.12802659879014e-05 1.01189745697063 0.683544303797468 7.2 7 2 abnormal myocardium layer morphology 4.28536738032839e-07 1.12802659879014e-05 1.01189745697063 0.683544303797468 7.2 7 2 abnormal developmental patterning 2.7574723480091e-07 7.6213471840807e-06 1.01098336712694 0.682926829268293 7.2 7 2 double outlet right ventricle 4.80580325934008e-09 1.86788056368882e-07 1.00997103398228 0.682242990654206 7.2 7 2 infertility 4.80580325934008e-09 1.86788056368882e-07 1.00997103398228 0.682242990654206 7.2 7 2 abnormal abdominal fat pad morphology 0.00766304998599758 0.0500310678219658 1.00934216036212 0.681818181818182 7.2 7 2 cleft upper lip 0.00766304998599758 0.0500310678219658 1.00934216036212 0.681818181818182 7.2 7 2 abnormal sperm midpiece morphology 0.00766304998599758 0.0500310678219658 1.00934216036212 0.681818181818182 7.2 7 2 pulmonary vascular congestion 0.00766304998599758 0.0500310678219658 1.00934216036212 0.681818181818182 7.2 7 2 increased mammary gland tumor incidence 0.00766304998599758 0.0500310678219658 1.00934216036212 0.681818181818182 7.2 7 2 abnormal motor capabilities/coordination/movement 8.54492424118734e-11 4.94465032975271e-09 1.00934216036212 0.681818181818182 7.2 7 2 insulin resistance 8.54492424118734e-11 4.94465032975271e-09 1.00934216036212 0.681818181818182 7.2 7 2 perinatal lethality, incomplete penetrance 2.18463757640515e-17 3.10530626931875e-15 1.00874667826161 0.68141592920354 7.2 7 2 prenatal lethality, incomplete penetrance 8.43644996331711e-23 1.90778811670466e-20 1.00801407857217 0.680921052631579 7.2 7 2 decreased hemoglobin content 2.31063921680128e-11 1.4369287629483e-09 1.00791046935452 0.680851063829787 7.2 7 2 increased B cell derived lymphoma incidence 6.93416165712958e-05 0.00105496801970091 1.00665058126782 0.68 7.2 7 2 decreased circulating alkaline phosphatase level 6.93416165712958e-05 0.00105496801970091 1.00665058126782 0.68 7.2 7 2 mandible hypoplasia 0.00475102332059127 0.0339115366139764 1.00665058126782 0.68 7.2 7 2 abnormal thyroid gland morphology 0.00475102332059127 0.0339115366139764 1.00665058126782 0.68 7.2 7 2 abnormal nest building behavior 0.00475102332059127 0.0339115366139764 1.00665058126782 0.68 7.2 7 2 abnormal keratinocyte physiology 0.00475102332059127 0.0339115366139764 1.00665058126782 0.68 7.2 7 2 abnormal lens morphology 2.25304695772463e-10 1.25942793423371e-08 1.00618796611099 0.6796875 7.2 7 2 abnormal craniofacial morphology 1.27098213085403e-08 4.48449368865163e-07 1.00607568087875 0.679611650485437 7.2 7 2 decreased heart weight 4.71347726602202e-07 1.22772509939579e-05 1.0051884889203 0.679012345679012 7.2 7 2 decreased exploration in new environment 3.03106539596908e-07 8.28546722249791e-06 1.0045357691223 0.678571428571429 7.2 7 2 abnormal nervous system electrophysiology 3.03106539596908e-07 8.28546722249791e-06 1.0045357691223 0.678571428571429 7.2 7 2 abnormal circulating cholesterol level 0.0029615019489329 0.0241928935893944 1.0045357691223 0.678571428571429 7.2 7 2 shortened head 0.0029615019489329 0.0241928935893944 1.0045357691223 0.678571428571429 7.2 7 2 lymphoid hyperplasia 0.0029615019489329 0.0241928935893944 1.0045357691223 0.678571428571429 7.2 7 2 absent corpus callosum 0.0029615019489329 0.0241928935893944 1.0045357691223 0.678571428571429 7.2 7 2 failure of blastocyst to hatch from the zona pellucida 0.0029615019489329 0.0241928935893944 1.0045357691223 0.678571428571429 7.2 7 2 abnormal brainstem morphology 0.0029615019489329 0.0241928935893944 1.0045357691223 0.678571428571429 7.2 7 2 increased triglyceride level 0.0029615019489329 0.0241928935893944 1.0045357691223 0.678571428571429 7.2 7 2 corneal vascularization 0.0029615019489329 0.0241928935893944 1.0045357691223 0.678571428571429 7.2 7 2 prolonged QRS complex duration 0.0029615019489329 0.0241928935893944 1.0045357691223 0.678571428571429 7.2 7 2 abnormal vitelline vasculature morphology 2.20238013296428e-09 9.52768796651939e-08 1.00407602735154 0.678260869565217 7.2 7 2 abnormal seminiferous tubule morphology 1.64293637123927e-11 1.0346339806222e-09 1.00381151838753 0.678082191780822 7.2 7 2 increased tumor incidence 5.92643891468477e-10 3.00857485719967e-08 1.00283027545656 0.67741935483871 7.2 7 2 abnormal postnatal growth/weight/body size 0.00185408972484865 0.0167103195310182 1.00283027545656 0.67741935483871 7.2 7 2 abnormal capillary morphology 0.00185408972484865 0.0167103195310182 1.00283027545656 0.67741935483871 7.2 7 2 preaxial polydactyly 0.00185408972484865 0.0167103195310182 1.00283027545656 0.67741935483871 7.2 7 2 ventricular septal defect 1.03167781869686e-10 5.83249675911011e-09 1.00142575126124 0.676470588235294 7.2 7 2 abnormal extraembryonic tissue morphology 2.16017404962669e-08 7.41163165302949e-07 1.00142575126124 0.676470588235294 7.2 7 2 abnormal nervous system development 0.00116496845259961 0.0116849154267803 1.00142575126124 0.676470588235294 7.2 7 2 decreased osteoblast cell number 0.00116496845259961 0.0116849154267803 1.00142575126124 0.676470588235294 7.2 7 2 reduced fertility 6.66597897109992e-11 3.99557173267736e-09 1.00111251205221 0.676258992805755 7.2 7 2 increased circulating free fatty acid level 3.03044096379784e-06 6.61247534863783e-05 1.00081250830272 0.676056338028169 7.2 7 2 abnormal breathing pattern 0.000734195676771598 0.00783824783677832 1.00024898774625 0.675675675675676 7.2 7 2 abnormal social investigation 8.01294366790144e-07 1.96359666573543e-05 0.9992487387585 0.675 7.2 7 2 abnormal retinal pigment epithelium morphology 8.01294366790144e-07 1.96359666573543e-05 0.9992487387585 0.675 7.2 7 2 decreased oxygen consumption 0.000293771113531263 0.00370941951730466 0.998388059396951 0.674418604651163 7.2 7 2 abnormal locomotor behavior 1.36947828788561e-07 4.03145235634964e-06 0.997639642560821 0.673913043478261 7.2 7 2 abnormal embryonic tissue morphology 3.03796495574998e-11 1.8659105746736e-09 0.996982868602585 0.673469387755102 7.2 7 2 increased T cell derived lymphoma incidence 0.000118462853751955 0.00168386484975993 0.996982868602585 0.673469387755102 7.2 7 2 abnormal learning/memory/conditioning 4.80582330534777e-05 0.000766313171285422 0.995884264890626 0.672727272727273 7.2 7 2 internal hemorrhage 8.01628561531761e-06 0.000157632493818993 0.994277351998507 0.671641791044776 7.2 7 2 decreased white adipose tissue amount 8.01628561531761e-06 0.000157632493818993 0.994277351998507 0.671641791044776 7.2 7 2 decreased bone marrow cell number 3.29082350025979e-06 7.08737961636036e-05 0.993672008100791 0.671232876712329 7.2 7 2 abnormal fertility/fecundity 3.29082350025979e-06 7.08737961636036e-05 0.993672008100791 0.671232876712329 7.2 7 2 hunched posture 1.35454833119866e-06 3.16379246371518e-05 0.99315861517488 0.670886075949367 7.2 7 2 abnormal locomotor activation 2.3097413606834e-07 6.41953255273738e-06 0.992334929821221 0.67032967032967 7.2 7 2 edema 1.68517006767417e-12 1.1808057868562e-10 0.98978126578146 0.668604651162791 7.2 7 2 abnormal spermatogenesis 2.94402403304592e-13 2.32484437530213e-11 0.989594161572427 0.668478260869565 7.2 7 2 hemorrhage 1.78352911710778e-16 2.33501509410821e-14 0.989012148054118 0.668085106382979 7.2 7 2 decreased body length 6.18055934439136e-19 1.06028561166714e-16 0.988713269493406 0.667883211678832 7.2 7 2 decreased total body fat amount 1.00629242550392e-22 2.17665426820957e-20 0.988389748250811 0.667664670658683 7.2 7 2 abnormal gluconeogenesis 0.000127533927878329 0.00178225081796261 0.986912334576296 0.666666666666667 7.2 7 2 abnormal adrenal gland morphology 0.00818855118915988 0.0531828226711102 0.986912334576296 0.666666666666667 7.2 7 2 abnormal retinal ganglion layer morphology 0.00818855118915988 0.0531828226711102 0.986912334576296 0.666666666666667 7.2 7 2 increased body temperature 0.00818855118915988 0.0531828226711102 0.986912334576296 0.666666666666667 7.2 7 2 abnormal mating frequency 0.0599850125560197 0.222206873386174 0.986912334576296 0.666666666666667 7.2 7 2 impaired embryo implantation 0.0599850125560197 0.222206873386174 0.986912334576296 0.666666666666667 7.2 7 2 altered tumor susceptibility 0.0599850125560197 0.222206873386174 0.986912334576296 0.666666666666667 7.2 7 2 abnormal rostral-caudal body axis extension 0.0599850125560197 0.222206873386174 0.986912334576296 0.666666666666667 7.2 7 2 stria vascularis degeneration 0.0599850125560197 0.222206873386174 0.986912334576296 0.666666666666667 7.2 7 2 abnormal amacrine cell morphology 0.0599850125560197 0.222206873386174 0.986912334576296 0.666666666666667 7.2 7 2 increased fibrosarcoma incidence 0.0599850125560197 0.222206873386174 0.986912334576296 0.666666666666667 7.2 7 2 abnormal gait 5.51431919808683e-21 1.14307241710342e-18 0.986912334576296 0.666666666666667 7.2 7 2 decreased insulin secretion 3.875759882344e-07 1.03111793661291e-05 0.986912334576296 0.666666666666667 7.2 7 2 abnormal sternum morphology 8.64261153944445e-06 0.000168615656504848 0.986912334576296 0.666666666666667 7.2 7 2 muscular ventricular septal defect 3.30429943456328e-05 0.00054979564170409 0.986912334576296 0.666666666666667 7.2 7 2 small placenta 0.000316015454783469 0.00394029295124752 0.986912334576296 0.666666666666667 7.2 7 2 abnormal metabolism 0.000316015454783469 0.00394029295124752 0.986912334576296 0.666666666666667 7.2 7 2 abnormal spleen white pulp morphology 0.000498783913942999 0.00570448269394579 0.986912334576296 0.666666666666667 7.2 7 2 spina bifida 0.000498783913942999 0.00570448269394579 0.986912334576296 0.666666666666667 7.2 7 2 abnormal cytotoxic T cell physiology 0.000498783913942999 0.00570448269394579 0.986912334576296 0.666666666666667 7.2 7 2 abnormal pharyngeal arch morphology 0.00125095393177875 0.012522124367403 0.986912334576296 0.666666666666667 7.2 7 2 delayed eyelid opening 0.00317409870959825 0.0253469359233568 0.986912334576296 0.666666666666667 7.2 7 2 abnormal spleen marginal zone morphology 0.00317409870959825 0.0253469359233568 0.986912334576296 0.666666666666667 7.2 7 2 abnormal microglial cell physiology 0.00317409870959825 0.0253469359233568 0.986912334576296 0.666666666666667 7.2 7 2 liver hemorrhage 0.00317409870959825 0.0253469359233568 0.986912334576296 0.666666666666667 7.2 7 2 abnormal cellular respiration 0.00317409870959825 0.0253469359233568 0.986912334576296 0.666666666666667 7.2 7 2 trunk curl 0.0132680268589807 0.0756110350783838 0.986912334576296 0.666666666666667 7.2 7 2 left pulmonary isomerism 0.0132680268589807 0.0756110350783838 0.986912334576296 0.666666666666667 7.2 7 2 abnormal erythrocyte physiology 0.0132680268589807 0.0756110350783838 0.986912334576296 0.666666666666667 7.2 7 2 abnormal tumor vascularization 0.0132680268589807 0.0756110350783838 0.986912334576296 0.666666666666667 7.2 7 2 cortical renal glomerulopathies 0.0216723357481842 0.11104003125357 0.986912334576296 0.666666666666667 7.2 7 2 eye inflammation 0.0216723357481842 0.11104003125357 0.986912334576296 0.666666666666667 7.2 7 2 abnormal redox activity 0.0216723357481842 0.11104003125357 0.986912334576296 0.666666666666667 7.2 7 2 decreased cellular sensitivity to gamma-irradiation 0.0216723357481842 0.11104003125357 0.986912334576296 0.666666666666667 7.2 7 2 decreased heart rate variability 0.0216723357481842 0.11104003125357 0.986912334576296 0.666666666666667 7.2 7 2 long tibia 0.0216723357481842 0.11104003125357 0.986912334576296 0.666666666666667 7.2 7 2 abnormal eye anterior chamber morphology 0.0216723357481842 0.11104003125357 0.986912334576296 0.666666666666667 7.2 7 2 decreased lactate dehydrogenase level 0.0216723357481842 0.11104003125357 0.986912334576296 0.666666666666667 7.2 7 2 primary atelectasis 0.0216723357481842 0.11104003125357 0.986912334576296 0.666666666666667 7.2 7 2 decreased hepatocyte number 0.0357835095270352 0.155342896943281 0.986912334576296 0.666666666666667 7.2 7 2 abnormal prostate gland morphology 0.0357835095270352 0.155342896943281 0.986912334576296 0.666666666666667 7.2 7 2 abnormal cricoid cartilage morphology 0.0357835095270352 0.155342896943281 0.986912334576296 0.666666666666667 7.2 7 2 abnormal bronchus morphology 0.0357835095270352 0.155342896943281 0.986912334576296 0.666666666666667 7.2 7 2 abnormal neurotransmitter secretion 0.0357835095270352 0.155342896943281 0.986912334576296 0.666666666666667 7.2 7 2 abnormal secondary palate development 0.0357835095270352 0.155342896943281 0.986912334576296 0.666666666666667 7.2 7 2 bicuspid aortic valve 0.0357835095270352 0.155342896943281 0.986912334576296 0.666666666666667 7.2 7 2 herniated liver 0.0357835095270352 0.155342896943281 0.986912334576296 0.666666666666667 7.2 7 2 renal tubular acidosis 0.102893958185433 0.308829503407067 0.986912334576296 0.666666666666667 7.2 7 2 abnormal urinary bladder urothelium morphology 0.102893958185433 0.308829503407067 0.986912334576296 0.666666666666667 7.2 7 2 abnormal sympathetic neuron morphology 0.102893958185433 0.308829503407067 0.986912334576296 0.666666666666667 7.2 7 2 abnormal lens vesicle development 0.102893958185433 0.308829503407067 0.986912334576296 0.666666666666667 7.2 7 2 decreased level of surface class I molecules 0.102893958185433 0.308829503407067 0.986912334576296 0.666666666666667 7.2 7 2 abnormal lung volume 0.102893958185433 0.308829503407067 0.986912334576296 0.666666666666667 7.2 7 2 abnormal germ cell morphology 0.102893958185433 0.308829503407067 0.986912334576296 0.666666666666667 7.2 7 2 polycythemia 0.102893958185433 0.308829503407067 0.986912334576296 0.666666666666667 7.2 7 2 decreased circulating bicarbonate level 0.102893958185433 0.308829503407067 0.986912334576296 0.666666666666667 7.2 7 2 decreased fear-related response 0.102893958185433 0.308829503407067 0.986912334576296 0.666666666666667 7.2 7 2 abnormal thymus physiology 0.102893958185433 0.308829503407067 0.986912334576296 0.666666666666667 7.2 7 2 abnormal proprioceptive neuron morphology 0.102893958185433 0.308829503407067 0.986912334576296 0.666666666666667 7.2 7 2 short frontal bone 0.102893958185433 0.308829503407067 0.986912334576296 0.666666666666667 7.2 7 2 decreased cochlear hair cell number 0.102893958185433 0.308829503407067 0.986912334576296 0.666666666666667 7.2 7 2 abnormal posterior eye segment morphology 0.102893958185433 0.308829503407067 0.986912334576296 0.666666666666667 7.2 7 2 decreased susceptibility to atherosclerosis 0.102893958185433 0.308829503407067 0.986912334576296 0.666666666666667 7.2 7 2 abnormal leukopoiesis 0.102893958185433 0.308829503407067 0.986912334576296 0.666666666666667 7.2 7 2 increased tidal volume 0.102893958185433 0.308829503407067 0.986912334576296 0.666666666666667 7.2 7 2 absent cervical lymph nodes 0.102893958185433 0.308829503407067 0.986912334576296 0.666666666666667 7.2 7 2 abnormal retinal development 0.102893958185433 0.308829503407067 0.986912334576296 0.666666666666667 7.2 7 2 abnormal liver vasculature morphology 0.102893958185433 0.308829503407067 0.986912334576296 0.666666666666667 7.2 7 2 decreased transitional stage T1 B cell number 0.102893958185433 0.308829503407067 0.986912334576296 0.666666666666667 7.2 7 2 abnormal cerebellar layer morphology 0.102893958185433 0.308829503407067 0.986912334576296 0.666666666666667 7.2 7 2 abnormal heart left ventricle pressure 0.102893958185433 0.308829503407067 0.986912334576296 0.666666666666667 7.2 7 2 decreased effector memory CD4-positive, alpha-beta T cell number 0.102893958185433 0.308829503407067 0.986912334576296 0.666666666666667 7.2 7 2 abnormal lung lobe morphology 0.102893958185433 0.308829503407067 0.986912334576296 0.666666666666667 7.2 7 2 abnormal ureteric bud invasion 0.102893958185433 0.308829503407067 0.986912334576296 0.666666666666667 7.2 7 2 reduced AMPA-mediated synaptic currents 0.102893958185433 0.308829503407067 0.986912334576296 0.666666666666667 7.2 7 2 decreased pancreatic beta cell proliferation 0.102893958185433 0.308829503407067 0.986912334576296 0.666666666666667 7.2 7 2 trigeminal neuroma 0.102893958185433 0.308829503407067 0.986912334576296 0.666666666666667 7.2 7 2 abnormal coronary sinus connection 0.102893958185433 0.308829503407067 0.986912334576296 0.666666666666667 7.2 7 2 decreased platelet dense granule number 0.102893958185433 0.308829503407067 0.986912334576296 0.666666666666667 7.2 7 2 increased circulating alanine transaminase level 2.27654917899474e-06 5.1481055297722e-05 0.986912334576296 0.666666666666667 7.2 7 2 abnormal iris morphology 0.000788936231211938 0.00835447398386376 0.986912334576296 0.666666666666667 7.2 7 2 thin epidermis 0.00508542104273397 0.0360842842081401 0.986912334576296 0.666666666666667 7.2 7 2 decreased circulating fructosamine level 0.00508542104273397 0.0360842842081401 0.986912334576296 0.666666666666667 7.2 7 2 hyperactivity 9.59986534404624e-25 2.5136489519279e-22 0.985582264044522 0.665768194070081 7.2 7 2 embryonic lethality during organogenesis, incomplete penetrance 7.67217957670245e-16 8.87653334746388e-14 0.984766872979391 0.665217391304348 7.2 7 2 premature death 2.65083123279531e-55 2.63757707663133e-52 0.98347361564049 0.664343786295006 7.2 7 2 decreased leukocyte cell number 5.73215790589423e-10 2.93994696719833e-08 0.983310464742076 0.664233576642336 7.2 7 2 decreased bone mineral content 2.69300622392998e-14 2.52786904982106e-12 0.982167563736987 0.663461538461538 7.2 7 2 decreased cardiac muscle contractility 7.13850793695764e-08 2.24772639154204e-06 0.982167563736987 0.663461538461538 7.2 7 2 abnormal bone structure 2.38006402310485e-13 1.90980943789462e-11 0.981798799163984 0.663212435233161 7.2 7 2 decreased body weight 6.96903018119264e-79 1.73354625757167e-75 0.981730646228359 0.663166397415186 7.2 7 2 kidney cysts 5.93073840654875e-06 0.000119455156164292 0.980244007991321 0.662162162162162 7.2 7 2 abnormal ovary morphology 9.25435212159783e-06 0.000179845319550583 0.979962247713083 0.661971830985915 7.2 7 2 increased heart weight 6.14642377918832e-10 3.08873316176383e-08 0.979812245838337 0.661870503597122 7.2 7 2 postnatal growth retardation 8.41801452510749e-39 5.23495278280122e-36 0.979655626233823 0.661764705882353 7.2 7 2 abnormal inhibitory postsynaptic currents 1.44511965448992e-05 0.000264318760334094 0.979655626233823 0.661764705882353 7.2 7 2 pericardial effusion 3.53270768648242e-05 0.000583894376752494 0.978953364136165 0.661290322580645 7.2 7 2 decreased circulating cholesterol level 1.45855904088325e-12 1.05164220701364e-10 0.978822889210917 0.66120218579235 7.2 7 2 atrioventricular septal defect 0.000136062083265967 0.00189080688337482 0.977601840853878 0.660377358490566 7.2 7 2 decreased respiratory quotient 0.000213815843573235 0.00283662352473825 0.977043211230533 0.66 7.2 7 2 enlarged spleen 1.021095698107e-18 1.6933170326941e-16 0.976631997757793 0.659722222222222 7.2 7 2 increased respiratory quotient 0.000336512751496292 0.00418537734673513 0.976413267187187 0.659574468085106 7.2 7 2 small testis 5.82914151864747e-18 9.06249345477224e-16 0.976185026591771 0.659420289855073 7.2 7 2 osteoporosis 0.000530528091682739 0.00605361755991198 0.975697421683384 0.659090909090909 7.2 7 2 cardiac fibrosis 1.67131902205853e-06 3.86051507352015e-05 0.97530160122834 0.658823529411765 7.2 7 2 anemia 5.10180991216707e-14 4.53241148446985e-12 0.975219060469942 0.658767772511848 7.2 7 2 decreased hair follicle number 0.00132676717992954 0.0132013334402989 0.97392664596345 0.657894736842105 7.2 7 2 neonatal lethality, incomplete penetrance 8.46954981088752e-17 1.17044473081015e-14 0.973626976226231 0.657692307692308 7.2 7 2 decreased percent body fat/body weight 9.84770657992727e-06 0.000189159614807483 0.973392987527306 0.657534246575342 7.2 7 2 abnormal dermal layer morphology 0.00210598560726737 0.0185462798975297 0.972813586939492 0.657142857142857 7.2 7 2 increased carcinoma incidence 0.00210598560726737 0.0185462798975297 0.972813586939492 0.657142857142857 7.2 7 2 abnormal midbrain development 0.00210598560726737 0.0185462798975297 0.972813586939492 0.657142857142857 7.2 7 2 abnormal embryonic epiblast morphology 0.00210598560726737 0.0185462798975297 0.972813586939492 0.657142857142857 7.2 7 2 decreased caudal vertebrae number 3.7504777821255e-05 0.000615796269507405 0.971491829348541 0.65625 7.2 7 2 abnormal embryonic hematopoiesis 0.00335305369393447 0.0263946869103228 0.971491829348541 0.65625 7.2 7 2 pancreatic islet hyperplasia 0.00335305369393447 0.0263946869103228 0.971491829348541 0.65625 7.2 7 2 increased double-negative T cell number 5.86682155252116e-05 0.000900846827894839 0.970733443845537 0.655737704918033 7.2 7 2 abnormal blood vessel morphology 7.43430331217131e-10 3.5908406774808e-08 0.969896604669808 0.655172413793103 7.2 7 2 abnormal spinal nerve morphology 0.00535794136733743 0.0374905180063343 0.969896604669808 0.655172413793103 7.2 7 2 short sternum 0.00535794136733743 0.0374905180063343 0.969896604669808 0.655172413793103 7.2 7 2 abnormal contextual conditioning behavior 0.000144001914928892 0.0019955697124547 0.968968473947636 0.654545454545455 7.2 7 2 eyelids open at birth 0.000226004281757043 0.00297452725328383 0.96793325121906 0.653846153846154 7.2 7 2 ventricular hypoplasia 0.00859906113656386 0.0552004247153616 0.96793325121906 0.653846153846154 7.2 7 2 no spontaneous movement 0.00859906113656386 0.0552004247153616 0.96793325121906 0.653846153846154 7.2 7 2 abnormal heart morphology 1.14262882461585e-14 1.1178245869168e-12 0.967686769617017 0.653679653679654 7.2 7 2 spleen hyperplasia 1.04193676343503e-05 0.000197096402969175 0.96717408788477 0.653333333333333 7.2 7 2 absent kidney 0.000355185648196503 0.00426823333279614 0.966771266523718 0.653061224489796 7.2 7 2 increased sarcoma incidence 0.000355185648196503 0.00426823333279614 0.966771266523718 0.653061224489796 7.2 7 2 impaired righting response 7.7625471971465e-07 1.93093361529019e-05 0.966135232795742 0.652631578947368 7.2 7 2 abnormal cranial nerve morphology 0.0138749902046518 0.0785302346622782 0.965457718607246 0.652173913043478 7.2 7 2 conjunctivitis 0.0138749902046518 0.0785302346622782 0.965457718607246 0.652173913043478 7.2 7 2 abnormal corneal stroma morphology 0.0138749902046518 0.0785302346622782 0.965457718607246 0.652173913043478 7.2 7 2 abnormal lens development 0.0138749902046518 0.0785302346622782 0.965457718607246 0.652173913043478 7.2 7 2 postnatal lethality, incomplete penetrance 2.20688583597296e-33 9.98114275815041e-31 0.964324552270853 0.651408450704225 7.2 7 2 decreased body size 4.1357830432525e-46 2.93936009145446e-43 0.962796055723868 0.650375939849624 7.2 7 2 abnormal pericardium morphology 0.0225393739962147 0.11384100064078 0.962239526211889 0.65 7.2 7 2 small gonad 0.0225393739962147 0.11384100064078 0.962239526211889 0.65 7.2 7 2 increased urine glucose level 0.0225393739962147 0.11384100064078 0.962239526211889 0.65 7.2 7 2 abnormal Peyer's patch T cell area morphology 0.0225393739962147 0.11384100064078 0.962239526211889 0.65 7.2 7 2 decreased myocardial infarction size 0.0225393739962147 0.11384100064078 0.962239526211889 0.65 7.2 7 2 abnormal hyoid bone morphology 0.0225393739962147 0.11384100064078 0.962239526211889 0.65 7.2 7 2 abnormal physiological neovascularization 0.0225393739962147 0.11384100064078 0.962239526211889 0.65 7.2 7 2 decreased muscle cell glucose uptake 0.0225393739962147 0.11384100064078 0.962239526211889 0.65 7.2 7 2 absent vitelline blood vessels 0.000151322473529813 0.00209119251614116 0.960940957350604 0.649122807017544 7.2 7 2 increased erythroid progenitor cell number 0.00220496917179196 0.0193128901930722 0.960239028236396 0.648648648648649 7.2 7 2 increased circulating triglyceride level 2.09249797621346e-09 9.13173458917716e-08 0.959687166725915 0.648275862068965 7.2 7 2 corneal opacity 2.66139275047006e-05 0.000451891772477425 0.959111987123443 0.647887323943662 7.2 7 2 enlarged liver sinusoidal spaces 0.00350045518798523 0.027381705283375 0.957885501206405 0.647058823529412 7.2 7 2 abnormal oocyte morphology 0.00350045518798523 0.027381705283375 0.957885501206405 0.647058823529412 7.2 7 2 thin skin 0.00350045518798523 0.027381705283375 0.957885501206405 0.647058823529412 7.2 7 2 abnormal vision 0.00350045518798523 0.027381705283375 0.957885501206405 0.647058823529412 7.2 7 2 abnormal adipose tissue morphology 0.0369353062204415 0.158817005639851 0.957885501206405 0.647058823529412 7.2 7 2 abnormal bone marrow cavity morphology 0.0369353062204415 0.158817005639851 0.957885501206405 0.647058823529412 7.2 7 2 increased incidence of corneal inflammation 0.0369353062204415 0.158817005639851 0.957885501206405 0.647058823529412 7.2 7 2 enhanced behavioral response to cocaine 0.0369353062204415 0.158817005639851 0.957885501206405 0.647058823529412 7.2 7 2 increased circulating magnesium level 0.0369353062204415 0.158817005639851 0.957885501206405 0.647058823529412 7.2 7 2 abnormal ductus venosus valve morphology 0.0369353062204415 0.158817005639851 0.957885501206405 0.647058823529412 7.2 7 2 decreased bone mineral density 7.93460390580916e-16 8.97151237077286e-14 0.957230760604077 0.646616541353383 7.2 7 2 overriding aortic valve 0.000584369752698417 0.00660736254471505 0.956071324120787 0.645833333333333 7.2 7 2 abnormal heart development 6.25393789778677e-10 3.11133410414892e-08 0.955680931583375 0.645569620253165 7.2 7 2 hypoglycemia 2.06363778205932e-06 4.70944860813996e-05 0.95507645281577 0.645161290322581 7.2 7 2 abnormal nose morphology 0.00557411504550661 0.0388392469907498 0.95507645281577 0.645161290322581 7.2 7 2 small cranium 0.00557411504550661 0.0388392469907498 0.95507645281577 0.645161290322581 7.2 7 2 abnormal ectoderm development 0.000919332246062663 0.00959540289406707 0.954015256757086 0.644444444444444 7.2 7 2 abnormal cell migration 0.000919332246062663 0.00959540289406707 0.954015256757086 0.644444444444444 7.2 7 2 syndactyly 0.00015800526433563 0.002171481188038 0.95345767916693 0.644067796610169 7.2 7 2 hydroencephaly 1.63179788206105e-07 4.692597955638e-06 0.952584949025816 0.643478260869565 7.2 7 2 reduced male fertility 2.1965927029706e-13 1.79148339299651e-11 0.952131283137484 0.643171806167401 7.2 7 2 enhanced long term potentiation 0.000247144843109724 0.00321030181323989 0.951665465484285 0.642857142857143 7.2 7 2 abnormal blood flow velocity 0.0612412133842066 0.222206873386174 0.951665465484285 0.642857142857143 7.2 7 2 increased aggression towards males 0.0612412133842066 0.222206873386174 0.951665465484285 0.642857142857143 7.2 7 2 abnormal placing response 0.0612412133842066 0.222206873386174 0.951665465484285 0.642857142857143 7.2 7 2 abnormal prepulse inhibition 0.0612412133842066 0.222206873386174 0.951665465484285 0.642857142857143 7.2 7 2 intestinal obstruction 0.0612412133842066 0.222206873386174 0.951665465484285 0.642857142857143 7.2 7 2 abnormal ventral body wall morphology 0.0612412133842066 0.222206873386174 0.951665465484285 0.642857142857143 7.2 7 2 absent olfactory bulb 0.0612412133842066 0.222206873386174 0.951665465484285 0.642857142857143 7.2 7 2 vascular smooth muscle hypoplasia 0.0612412133842066 0.222206873386174 0.951665465484285 0.642857142857143 7.2 7 2 increased circulating growth hormone level 0.0612412133842066 0.222206873386174 0.951665465484285 0.642857142857143 7.2 7 2 spina bifida occulta 0.0612412133842066 0.222206873386174 0.951665465484285 0.642857142857143 7.2 7 2 decreased tongue size 0.0612412133842066 0.222206873386174 0.951665465484285 0.642857142857143 7.2 7 2 increased stomach tumor incidence 0.0612412133842066 0.222206873386174 0.951665465484285 0.642857142857143 7.2 7 2 decreased compact bone area 0.0612412133842066 0.222206873386174 0.951665465484285 0.642857142857143 7.2 7 2 abnormal renal tubule epithelial cell primary cilium morphology 0.0612412133842066 0.222206873386174 0.951665465484285 0.642857142857143 7.2 7 2 decreased anxiety-related response 7.1245370440901e-08 2.24772639154204e-06 0.950805785750334 0.642276422764228 7.2 7 2 enlarged heart 1.48949331260272e-13 1.23503820503309e-11 0.950753908525009 0.642241379310345 7.2 7 2 decreased lymphocyte cell number 4.80549855455629e-08 1.56257224241291e-06 0.948361071506909 0.640625 7.2 7 2 decreased circulating LDL cholesterol level 0.000105158993502877 0.00151642316717917 0.948361071506909 0.640625 7.2 7 2 microphthalmia 2.50440526204615e-09 1.0636295570538e-07 0.948209890083108 0.640522875816993 7.2 7 2 short stride length 0.000606509745304533 0.00679591437587849 0.947435841193244 0.64 7.2 7 2 ruffled hair 0.0142997118443929 0.0802946573655246 0.947435841193244 0.64 7.2 7 2 abnormal primitive streak morphology 0.0142997118443929 0.0802946573655246 0.947435841193244 0.64 7.2 7 2 abnormal maternal nurturing 0.000164042367754502 0.00224206258126002 0.946465107749399 0.639344262295082 7.2 7 2 abnormal myocardial fiber morphology 2.23887083569159e-06 5.08601936418522e-05 0.94621491871748 0.639175257731959 7.2 7 2 abnormal neuromuscular synapse morphology 4.49603135041998e-05 0.000721540515107722 0.945790987302284 0.638888888888889 7.2 7 2 abnormal digit morphology 4.49603135041998e-05 0.000721540515107722 0.945790987302284 0.638888888888889 7.2 7 2 heart right ventricle hypertrophy 0.0036187339562088 0.0281300022377169 0.945790987302284 0.638888888888889 7.2 7 2 narrow eye opening 0.0036187339562088 0.0281300022377169 0.945790987302284 0.638888888888889 7.2 7 2 spleen hypoplasia 9.70779211083478e-07 2.32193585343284e-05 0.944616091665883 0.638095238095238 7.2 7 2 abnormal spermiogenesis 0.000256081619286326 0.0033091066388298 0.944373009810076 0.637931034482759 7.2 7 2 impaired glucose tolerance 7.67582248685846e-14 6.58400290898635e-12 0.943137997155573 0.637096774193548 7.2 7 2 abnormal astrocyte morphology 0.00149563064501206 0.0143644062913803 0.942052683004646 0.636363636363636 7.2 7 2 omphalocele 0.00149563064501206 0.0143644062913803 0.942052683004646 0.636363636363636 7.2 7 2 testis hypoplasia 0.0230767363867012 0.115042769913059 0.942052683004646 0.636363636363636 7.2 7 2 increased coping response 0.0230767363867012 0.115042769913059 0.942052683004646 0.636363636363636 7.2 7 2 abnormal vascular branching morphogenesis 0.0230767363867012 0.115042769913059 0.942052683004646 0.636363636363636 7.2 7 2 parakeratosis 0.0230767363867012 0.115042769913059 0.942052683004646 0.636363636363636 7.2 7 2 abnormal retinal outer plexiform layer morphology 0.0230767363867012 0.115042769913059 0.942052683004646 0.636363636363636 7.2 7 2 abnormal ear position 0.103249564304687 0.308829503407067 0.942052683004646 0.636363636363636 7.2 7 2 decreased atrioventricular cushion size 0.103249564304687 0.308829503407067 0.942052683004646 0.636363636363636 7.2 7 2 social withdrawal 0.103249564304687 0.308829503407067 0.942052683004646 0.636363636363636 7.2 7 2 vasculitis 0.103249564304687 0.308829503407067 0.942052683004646 0.636363636363636 7.2 7 2 decreased post-tetanic potentiation 0.103249564304687 0.308829503407067 0.942052683004646 0.636363636363636 7.2 7 2 allodynia 0.103249564304687 0.308829503407067 0.942052683004646 0.636363636363636 7.2 7 2 abnormal radial glial cell morphology 0.103249564304687 0.308829503407067 0.942052683004646 0.636363636363636 7.2 7 2 dilated renal glomerular capsule 0.103249564304687 0.308829503407067 0.942052683004646 0.636363636363636 7.2 7 2 abnormal ureter development 0.103249564304687 0.308829503407067 0.942052683004646 0.636363636363636 7.2 7 2 abnormal coronal suture morphology 0.103249564304687 0.308829503407067 0.942052683004646 0.636363636363636 7.2 7 2 abnormal Bruch membrane morphology 0.103249564304687 0.308829503407067 0.942052683004646 0.636363636363636 7.2 7 2 increased glycogen level 0.103249564304687 0.308829503407067 0.942052683004646 0.636363636363636 7.2 7 2 abnormal extraembryonic ectoderm morphology 0.103249564304687 0.308829503407067 0.942052683004646 0.636363636363636 7.2 7 2 decreased core body temperature 0.103249564304687 0.308829503407067 0.942052683004646 0.636363636363636 7.2 7 2 thin hypoglossal nerve 0.103249564304687 0.308829503407067 0.942052683004646 0.636363636363636 7.2 7 2 abnormal platelet physiology 0.000400074912623991 0.00476165715383817 0.942052683004646 0.636363636363636 7.2 7 2 cardiovascular system phenotype 0.00573969635323818 0.0398256476392747 0.942052683004646 0.636363636363636 7.2 7 2 azoospermia 2.79958360668688e-09 1.1606607036056e-07 0.940359865964207 0.635220125786163 7.2 7 2 kinked neural tube 0.000625569747231934 0.00696243734335318 0.939464626183205 0.634615384615385 7.2 7 2 abnormal female meiosis 0.000625569747231934 0.00696243734335318 0.939464626183205 0.634615384615385 7.2 7 2 lethargy 5.54697491138072e-06 0.000112637551771915 0.939158511935507 0.634408602150538 7.2 7 2 abnormal cranium morphology 5.35767350955487e-08 1.71964036838939e-06 0.939039721331923 0.634328358208955 7.2 7 2 Leydig cell hyperplasia 0.00235374839088605 0.0204718500780736 0.938770269475013 0.634146341463415 7.2 7 2 palatal shelves fail to meet at midline 0.00235374839088605 0.0204718500780736 0.938770269475013 0.634146341463415 7.2 7 2 reduced long term potentiation 6.72869973922431e-07 1.68217493480608e-05 0.938447889574782 0.633928571428571 7.2 7 2 abnormal skeletal muscle fiber morphology 7.21743885699164e-05 0.00108808358525859 0.938261726533803 0.633802816901408 7.2 7 2 decreased liver weight 7.21743885699164e-05 0.00108808358525859 0.938261726533803 0.633802816901408 7.2 7 2 increased erythrocyte cell number 0.00026394452505013 0.00340187567907875 0.937566717847481 0.633333333333333 7.2 7 2 abnormal response to new environment 0.00913003323070514 0.0567065110146793 0.937566717847481 0.633333333333333 7.2 7 2 increased anxiety-related response 3.59387955073069e-08 1.19197005099235e-06 0.937211713410583 0.633093525179856 7.2 7 2 increased bone mineral content 1.03784861692543e-06 2.47047697091101e-05 0.9371140057674 0.63302752293578 7.2 7 2 polydactyly 3.70130687832093e-06 7.90300502989126e-05 0.936559664444852 0.63265306122449 7.2 7 2 abnormal craniofacial development 0.000979075710451712 0.0101266146767095 0.936559664444852 0.63265306122449 7.2 7 2 male infertility 1.54577265411254e-25 4.80638684638118e-23 0.935898973345712 0.63220675944334 7.2 7 2 enlarged adrenal glands 0.0374913125012647 0.158817005639851 0.934969580124912 0.631578947368421 7.2 7 2 thin dermal layer 0.0374913125012647 0.158817005639851 0.934969580124912 0.631578947368421 7.2 7 2 increased malignant tumor incidence 0.0374913125012647 0.158817005639851 0.934969580124912 0.631578947368421 7.2 7 2 increased susceptibility to ischemic brain injury 0.0374913125012647 0.158817005639851 0.934969580124912 0.631578947368421 7.2 7 2 abnormal response to novelty 0.0374913125012647 0.158817005639851 0.934969580124912 0.631578947368421 7.2 7 2 decreased eye pigmentation 0.0374913125012647 0.158817005639851 0.934969580124912 0.631578947368421 7.2 7 2 eyelids fail to open 0.0374913125012647 0.158817005639851 0.934969580124912 0.631578947368421 7.2 7 2 Leydig cell hypoplasia 0.0374913125012647 0.158817005639851 0.934969580124912 0.631578947368421 7.2 7 2 thin interventricular septum 0.0374913125012647 0.158817005639851 0.934969580124912 0.631578947368421 7.2 7 2 abnormal liver morphology 5.7033583015092e-10 2.93994696719833e-08 0.934534305646269 0.631284916201117 7.2 7 2 abnormal liver physiology 3.80764908982291e-06 8.09532231703802e-05 0.9326321561746 0.63 7.2 7 2 abnormal brain commissure morphology 0.0145722492960747 0.0814572362336758 0.932083871544279 0.62962962962963 7.2 7 2 decreased rib number 1.3631184207943e-05 0.000250240374297108 0.931467821397852 0.629213483146067 7.2 7 2 domed cranium 0.000115004920681816 0.00163939679195426 0.930517344029079 0.628571428571429 7.2 7 2 thick pulmonary interalveolar septum 0.00586032678612312 0.0404932302235591 0.930517344029079 0.628571428571429 7.2 7 2 decreased circulating thyroxine level 0.00586032678612312 0.0404932302235591 0.930517344029079 0.628571428571429 7.2 7 2 abnormal cornea morphology 4.91011663608007e-05 0.000780441861485571 0.929975084504587 0.628205128205128 7.2 7 2 abnormal left-right axis patterning 0.00240588657771161 0.0207560056992116 0.929533710473023 0.627906976744186 7.2 7 2 increased lung adenocarcinoma incidence 0.00100147461203965 0.0102940830473084 0.928858667836514 0.627450980392157 7.2 7 2 decreased circulating glucose level 2.98981497356048e-14 2.73196765377852e-12 0.928546551348666 0.627240143369176 7.2 7 2 postnatal lethality 4.97374888073757e-09 1.91817059547825e-07 0.927459784300615 0.626506024096386 7.2 7 2 abnormal glucose homeostasis 9.48617852435705e-10 4.41062973445573e-08 0.927263786882124 0.626373626373626 7.2 7 2 increased or absent threshold for auditory brainstem response 1.3429975886165e-14 1.28488711603213e-12 0.92715120705005 0.626297577854671 7.2 7 2 abnormal suckling behavior 2.15286570289426e-05 0.000375807258663122 0.925230313665278 0.625 7.2 7 2 hyperglycemia 2.15286570289426e-05 0.000375807258663122 0.925230313665278 0.625 7.2 7 2 curly tail 0.00156414985270945 0.0149073668912443 0.925230313665278 0.625 7.2 7 2 abnormal phalanx morphology 0.00156414985270945 0.0149073668912443 0.925230313665278 0.625 7.2 7 2 decreased metastatic potential 0.0233523885638049 0.115370539329622 0.925230313665278 0.625 7.2 7 2 increased stereotypic behavior 0.0233523885638049 0.115370539329622 0.925230313665278 0.625 7.2 7 2 small lymph nodes 0.0233523885638049 0.115370539329622 0.925230313665278 0.625 7.2 7 2 abnormal cardiac muscle contractility 0.0233523885638049 0.115370539329622 0.925230313665278 0.625 7.2 7 2 abnormal inner cell mass apoptosis 0.0233523885638049 0.115370539329622 0.925230313665278 0.625 7.2 7 2 decreased circulating phosphate level 0.00377820107500237 0.0290518552521434 0.925230313665277 0.625 7.2 7 2 failure of primitive streak formation 0.00927588396479352 0.057113270699069 0.925230313665277 0.625 7.2 7 2 increased circulating follicle stimulating hormone level 0.00927588396479352 0.057113270699069 0.925230313665277 0.625 7.2 7 2 abnormal long term potentiation 0.00927588396479352 0.057113270699069 0.925230313665277 0.625 7.2 7 2 bradykinesia 0.00927588396479352 0.057113270699069 0.925230313665277 0.625 7.2 7 2 abnormal hair follicle orientation 0.0614371631529027 0.222206873386174 0.925230313665277 0.625 7.2 7 2 abnormal mouth morphology 0.0614371631529027 0.222206873386174 0.925230313665277 0.625 7.2 7 2 abnormal meiosis 0.0614371631529027 0.222206873386174 0.925230313665277 0.625 7.2 7 2 abnormal olfaction 0.0614371631529027 0.222206873386174 0.925230313665277 0.625 7.2 7 2 abnormal epicardium morphology 0.0614371631529027 0.222206873386174 0.925230313665277 0.625 7.2 7 2 abnormal level of surface class II molecules 0.0614371631529027 0.222206873386174 0.925230313665277 0.625 7.2 7 2 decreased circulating growth hormone level 0.0614371631529027 0.222206873386174 0.925230313665277 0.625 7.2 7 2 loose skin 0.0614371631529027 0.222206873386174 0.925230313665277 0.625 7.2 7 2 decreased circulating triiodothyronine level 0.0614371631529027 0.222206873386174 0.925230313665277 0.625 7.2 7 2 kidney degeneration 0.0614371631529027 0.222206873386174 0.925230313665277 0.625 7.2 7 2 impaired somite development 0.0614371631529027 0.222206873386174 0.925230313665277 0.625 7.2 7 2 decreased liver cholesterol level 0.0614371631529027 0.222206873386174 0.925230313665277 0.625 7.2 7 2 increased heart left ventricle size 0.0614371631529027 0.222206873386174 0.925230313665277 0.625 7.2 7 2 decreased fibroblast apoptosis 0.0614371631529027 0.222206873386174 0.925230313665277 0.625 7.2 7 2 decreased adipocyte glucose uptake 0.0614371631529027 0.222206873386174 0.925230313665277 0.625 7.2 7 2 schistocytosis 0.178583545025275 0.414963905812287 0.925230313665277 0.625 7.2 7 2 abnormal cecum morphology 0.178583545025275 0.414963905812287 0.925230313665277 0.625 7.2 7 2 clubfoot 0.178583545025275 0.414963905812287 0.925230313665277 0.625 7.2 7 2 dry eyes 0.178583545025275 0.414963905812287 0.925230313665277 0.625 7.2 7 2 absent eyelids 0.178583545025275 0.414963905812287 0.925230313665277 0.625 7.2 7 2 preneoplasia 0.178583545025275 0.414963905812287 0.925230313665277 0.625 7.2 7 2 altered response to CNS ischemic injury 0.178583545025275 0.414963905812287 0.925230313665277 0.625 7.2 7 2 abnormal neuron apoptosis 0.178583545025275 0.414963905812287 0.925230313665277 0.625 7.2 7 2 decreased susceptibility to age related obesity 0.178583545025275 0.414963905812287 0.925230313665277 0.625 7.2 7 2 liver cysts 0.178583545025275 0.414963905812287 0.925230313665277 0.625 7.2 7 2 abnormal platelet shape 0.178583545025275 0.414963905812287 0.925230313665277 0.625 7.2 7 2 abnormal eyelid aperture 0.178583545025275 0.414963905812287 0.925230313665277 0.625 7.2 7 2 elevated level of mitotic sister chromatid exchange 0.178583545025275 0.414963905812287 0.925230313665277 0.625 7.2 7 2 binucleate 0.178583545025275 0.414963905812287 0.925230313665277 0.625 7.2 7 2 increased left ventricle systolic pressure 0.178583545025275 0.414963905812287 0.925230313665277 0.625 7.2 7 2 lymph node inflammation 0.178583545025275 0.414963905812287 0.925230313665277 0.625 7.2 7 2 bowed fibula 0.178583545025275 0.414963905812287 0.925230313665277 0.625 7.2 7 2 absent cochlear microphonics 0.178583545025275 0.414963905812287 0.925230313665277 0.625 7.2 7 2 abnormal NK cell morphology 0.178583545025275 0.414963905812287 0.925230313665277 0.625 7.2 7 2 non-pigmented tail tip 0.178583545025275 0.414963905812287 0.925230313665277 0.625 7.2 7 2 abnormal somite size 0.178583545025275 0.414963905812287 0.925230313665277 0.625 7.2 7 2 abnormal ilium morphology 0.178583545025275 0.414963905812287 0.925230313665277 0.625 7.2 7 2 choroidal neovascularization 0.178583545025275 0.414963905812287 0.925230313665277 0.625 7.2 7 2 increased pulmonary ventilation 0.178583545025275 0.414963905812287 0.925230313665277 0.625 7.2 7 2 abnormal thymus epithelium morphology 0.178583545025275 0.414963905812287 0.925230313665277 0.625 7.2 7 2 abnormal epidermal lamellar body morphology 0.178583545025275 0.414963905812287 0.925230313665277 0.625 7.2 7 2 enlarged inguinal lymph nodes 0.178583545025275 0.414963905812287 0.925230313665277 0.625 7.2 7 2 abnormal sphingomyelin level 0.178583545025275 0.414963905812287 0.925230313665277 0.625 7.2 7 2 abnormal frontonasal prominence morphology 0.178583545025275 0.414963905812287 0.925230313665277 0.625 7.2 7 2 abnormal lateral plate mesoderm morphology 0.178583545025275 0.414963905812287 0.925230313665277 0.625 7.2 7 2 decreased quadriceps weight 0.178583545025275 0.414963905812287 0.925230313665277 0.625 7.2 7 2 ostium secundum atrial septal defect 0.178583545025275 0.414963905812287 0.925230313665277 0.625 7.2 7 2 abnormal hepatic vein morphology 0.178583545025275 0.414963905812287 0.925230313665277 0.625 7.2 7 2 sinoatrial block 0.178583545025275 0.414963905812287 0.925230313665277 0.625 7.2 7 2 abnormal stomach position or orientation 0.178583545025275 0.414963905812287 0.925230313665277 0.625 7.2 7 2 abnormal foramen magnum morphology 0.178583545025275 0.414963905812287 0.925230313665277 0.625 7.2 7 2 abnormal bronchus epithelium morphology 0.178583545025275 0.414963905812287 0.925230313665277 0.625 7.2 7 2 absent ureteric bud 0.178583545025275 0.414963905812287 0.925230313665277 0.625 7.2 7 2 abnormal branching involved in ureteric bud morphogenesis 0.178583545025275 0.414963905812287 0.925230313665277 0.625 7.2 7 2 lethality during fetal growth through weaning, incomplete penetrance 0.178583545025275 0.414963905812287 0.925230313665277 0.625 7.2 7 2 increased circulating ferritin level 0.178583545025275 0.414963905812287 0.925230313665277 0.625 7.2 7 2 increased circulating lactate level 0.178583545025275 0.414963905812287 0.925230313665277 0.625 7.2 7 2 increased testis apoptosis 0.178583545025275 0.414963905812287 0.925230313665277 0.625 7.2 7 2 respiratory distress 3.40321978198176e-09 1.37650556222433e-07 0.924160683244855 0.624277456647399 7.2 7 2 perimembraneous ventricular septal defect 0.000181853904001997 0.00246518575588538 0.922548486669146 0.623188405797101 7.2 7 2 abnormal male meiosis 0.000429000263190734 0.00508161026041405 0.92219677165326 0.622950819672131 7.2 7 2 enlarged kidney 0.00101928658972081 0.0104555686265176 0.921738878519371 0.622641509433962 7.2 7 2 abnormal autopod morphology 0.00244482800798753 0.0207560056992116 0.921118178937876 0.622222222222222 7.2 7 2 increased circulating corticosterone level 0.00244482800798753 0.0207560056992116 0.921118178937876 0.622222222222222 7.2 7 2 albuminuria 0.00244482800798753 0.0207560056992116 0.921118178937876 0.622222222222222 7.2 7 2 increased granulocyte number 0.000119694716633553 0.00169652767878041 0.920229068726546 0.621621621621622 7.2 7 2 abnormal vocalization 0.00594134753060786 0.0407699365031367 0.920229068726546 0.621621621621622 7.2 7 2 impaired skeletal muscle contractility 0.00594134753060786 0.0407699365031367 0.920229068726546 0.621621621621622 7.2 7 2 decreased width of hypertrophic chondrocyte zone 0.00594134753060786 0.0407699365031367 0.920229068726546 0.621621621621622 7.2 7 2 abnormal pancreatic beta cell physiology 0.00594134753060786 0.0407699365031367 0.920229068726546 0.621621621621622 7.2 7 2 abnormal skin morphology 0.000281389943818933 0.00358034519309256 0.919622857218821 0.621212121212121 7.2 7 2 decreased T cell number 1.86180792544066e-08 6.43228779796338e-07 0.919483541530711 0.62111801242236 7.2 7 2 decreased birth weight 1.45282972956582e-05 0.000264755600900731 0.919386753789497 0.621052631578947 7.2 7 2 thrombocytopenia 9.80199139257183e-08 2.95544891988151e-06 0.918849414950345 0.620689655172414 7.2 7 2 abnormal spleen morphology 5.41875377252331e-09 2.07371538602334e-07 0.918849414950345 0.620689655172414 7.2 7 2 abnormal retinal pigmentation 3.37882038601908e-05 0.000560321047348164 0.918849414950345 0.620689655172414 7.2 7 2 abnormal embryonic erythropoiesis 0.0147184402112388 0.081632374638699 0.918849414950345 0.620689655172414 7.2 7 2 polychromatophilia 0.0147184402112388 0.081632374638699 0.918849414950345 0.620689655172414 7.2 7 2 increased retinal apoptosis 0.0147184402112388 0.081632374638699 0.918849414950345 0.620689655172414 7.2 7 2 abnormal visceral yolk sac morphology 7.8852615664637e-05 0.00117452623632206 0.91820324799187 0.620253164556962 7.2 7 2 abnormal interventricular septum morphology 0.00158694649569184 0.0150446467331418 0.917828471155955 0.62 7.2 7 2 increased body length 0.00158694649569184 0.0150446467331418 0.917828471155955 0.62 7.2 7 2 cyanosis 1.05371097533809e-09 4.85390009472872e-08 0.9175200610514 0.619791666666667 7.2 7 2 increased total body fat amount 3.44527507282481e-07 9.26499647962348e-06 0.91694466906529 0.619402985074627 7.2 7 2 increased circulating cholesterol level 5.51612513083503e-09 2.09486431495452e-07 0.916819128995593 0.619318181818182 7.2 7 2 postnatal lethality, complete penetrance 6.52185258748231e-18 9.83218685537106e-16 0.916601222657 0.619170984455959 7.2 7 2 increased circulating HDL cholesterol level 6.37029884596785e-06 0.000127791277252782 0.916418596392275 0.619047619047619 7.2 7 2 arrest of spermatogenesis 5.19894824479685e-05 0.000821103730725852 0.916418596392275 0.619047619047619 7.2 7 2 disheveled coat 0.00382445595401838 0.0292717974942176 0.916418596392275 0.619047619047619 7.2 7 2 abnormal eye pigmentation 0.03760531309422 0.158817005639851 0.916418596392275 0.619047619047619 7.2 7 2 abnormal anxiety-related response 0.03760531309422 0.158817005639851 0.916418596392275 0.619047619047619 7.2 7 2 liver degeneration 0.03760531309422 0.158817005639851 0.916418596392275 0.619047619047619 7.2 7 2 complete atrioventricular septal defect 0.03760531309422 0.158817005639851 0.916418596392275 0.619047619047619 7.2 7 2 increased circulating insulin level 2.89434999660734e-08 9.79550424021872e-07 0.915978010528625 0.61875 7.2 7 2 abnormal joint morphology 0.0010328277925354 0.0105509615356542 0.915136892061656 0.618181818181818 7.2 7 2 abnormal spleen red pulp morphology 0.0093569320817238 0.0573598160594362 0.914345251151568 0.617647058823529 7.2 7 2 decreased circulating HDL cholesterol level 8.05173306150809e-07 1.96359666573543e-05 0.913664934744461 0.6171875 7.2 7 2 epidermal hyperplasia 0.000673728067307712 0.00731728934807907 0.912893909483074 0.616666666666667 7.2 7 2 abnormal eating behavior 0.000673728067307712 0.00731728934807907 0.912893909483074 0.616666666666667 7.2 7 2 intracranial hemorrhage 0.000673728067307712 0.00731728934807907 0.912893909483074 0.616666666666667 7.2 7 2 increased mean corpuscular hemoglobin 1.49653713213065e-05 0.000270796787679769 0.912146248623546 0.616161616161616 7.2 7 2 distended pericardium 0.00160292239573199 0.0151319524075268 0.91099600114735 0.615384615384615 7.2 7 2 increased susceptibility to injury 0.00160292239573199 0.0151319524075268 0.91099600114735 0.615384615384615 7.2 7 2 abnormal stomach morphology 0.0234207529769195 0.11547893563942 0.91099600114735 0.615384615384615 7.2 7 2 increased susceptibility to otitis media 0.0234207529769195 0.11547893563942 0.91099600114735 0.615384615384615 7.2 7 2 increased pituitary adenoma incidence 0.101841093405579 0.308829503407067 0.91099600114735 0.615384615384615 7.2 7 2 abnormal lung interstitium morphology 0.101841093405579 0.308829503407067 0.91099600114735 0.615384615384615 7.2 7 2 dystrophic cardiac calcinosis 0.101841093405579 0.308829503407067 0.91099600114735 0.615384615384615 7.2 7 2 abnormal soleus morphology 0.101841093405579 0.308829503407067 0.91099600114735 0.615384615384615 7.2 7 2 abnormal GABAergic neuron morphology 0.101841093405579 0.308829503407067 0.91099600114735 0.615384615384615 7.2 7 2 abnormal afterhyperpolarization 0.101841093405579 0.308829503407067 0.91099600114735 0.615384615384615 7.2 7 2 small otic vesicle 0.101841093405579 0.308829503407067 0.91099600114735 0.615384615384615 7.2 7 2 hyperalgesia 0.101841093405579 0.308829503407067 0.91099600114735 0.615384615384615 7.2 7 2 increased circulating thyroxine level 0.101841093405579 0.308829503407067 0.91099600114735 0.615384615384615 7.2 7 2 increased prostaglandin level 0.101841093405579 0.308829503407067 0.91099600114735 0.615384615384615 7.2 7 2 increased rib number 0.00012298535105063 0.00172352710275178 0.91099600114735 0.615384615384615 7.2 7 2 abnormal rib morphology 5.41573857630869e-07 1.38170766241722e-05 0.910152486331473 0.614814814814815 7.2 7 2 incomplete embryo turning 0.00104241886089947 0.0105837425162752 0.90899820289922 0.614035087719298 7.2 7 2 increased hepatocellular carcinoma incidence 0.00104241886089947 0.0105837425162752 0.90899820289922 0.614035087719298 7.2 7 2 abnormal facial morphology 0.00104241886089947 0.0105837425162752 0.90899820289922 0.614035087719298 7.2 7 2 abnormal pulmonary alveolus morphology 1.513749677859e-05 0.000272858864034367 0.908741060550451 0.613861386138614 7.2 7 2 teratozoospermia 5.32592488274669e-05 0.000835850987118763 0.908407944325909 0.613636363636364 7.2 7 2 decreased blood urea nitrogen level 0.00385158717670501 0.0293440217520787 0.908407944325909 0.613636363636364 7.2 7 2 lethality, incomplete penetrance 0.00385158717670501 0.0293440217520787 0.908407944325909 0.613636363636364 7.2 7 2 prenatal lethality 0.00067954820900363 0.00733556282314307 0.907322630174982 0.612903225806452 7.2 7 2 increased lung adenoma incidence 0.0147602370239362 0.0816820680690574 0.907322630174982 0.612903225806452 7.2 7 2 abnormal retinal photoreceptor layer morphology 0.0147602370239362 0.0816820680690574 0.907322630174982 0.612903225806452 7.2 7 2 cardiac hypertrophy 2.31493556058241e-05 0.000401625573323958 0.906348062365986 0.612244897959184 7.2 7 2 abnormal long bone hypertrophic chondrocyte zone 0.00248795112995852 0.0209979338052114 0.906348062365986 0.612244897959184 7.2 7 2 neonatal lethality, complete penetrance 1.28118073467547e-19 2.4514900596194e-17 0.905751780746008 0.611842105263158 7.2 7 2 abnormal bone mineralization 2.89531865550204e-06 6.40187124938785e-05 0.905349331718751 0.611570247933884 7.2 7 2 right pulmonary isomerism 0.0609199741054173 0.222206873386174 0.904669640028271 0.611111111111111 7.2 7 2 abnormal phrenic nerve morphology 0.0609199741054173 0.222206873386174 0.904669640028271 0.611111111111111 7.2 7 2 abnormal thyroid cartilage morphology 0.0609199741054173 0.222206873386174 0.904669640028271 0.611111111111111 7.2 7 2 abnormal Peyer's patch follicle morphology 0.0609199741054173 0.222206873386174 0.904669640028271 0.611111111111111 7.2 7 2 acidosis 0.0609199741054173 0.222206873386174 0.904669640028271 0.611111111111111 7.2 7 2 increased circulating renin level 0.0609199741054173 0.222206873386174 0.904669640028271 0.611111111111111 7.2 7 2 abnormal body wall morphology 0.0609199741054173 0.222206873386174 0.904669640028271 0.611111111111111 7.2 7 2 decreased activity of thyroid 0.0609199741054173 0.222206873386174 0.904669640028271 0.611111111111111 7.2 7 2 absent ureter 0.0609199741054173 0.222206873386174 0.904669640028271 0.611111111111111 7.2 7 2 jerky movement 0.0609199741054173 0.222206873386174 0.904669640028271 0.611111111111111 7.2 7 2 decreased pulmonary respiratory rate 0.0609199741054173 0.222206873386174 0.904669640028271 0.611111111111111 7.2 7 2 abnormal pregnancy 0.0609199741054173 0.222206873386174 0.904669640028271 0.611111111111111 7.2 7 2 small thoracic cage 0.0609199741054173 0.222206873386174 0.904669640028271 0.611111111111111 7.2 7 2 increased gastrointestinal tumor incidence 0.0609199741054173 0.222206873386174 0.904669640028271 0.611111111111111 7.2 7 2 decreased fluid intake 0.0609199741054173 0.222206873386174 0.904669640028271 0.611111111111111 7.2 7 2 short snout 1.00924512415349e-05 0.000193115172794755 0.904669640028271 0.611111111111111 7.2 7 2 abnormal chondrocyte morphology 0.00161268178292611 0.0151379091887875 0.904669640028271 0.611111111111111 7.2 7 2 decreased tumor growth/size 0.00161268178292611 0.0151379091887875 0.904669640028271 0.611111111111111 7.2 7 2 decreased platelet aggregation 0.00161268178292611 0.0151379091887875 0.904669640028271 0.611111111111111 7.2 7 2 cleft palate 1.26993539623255e-06 2.99427895557201e-05 0.90404183319966 0.610687022900763 7.2 7 2 decreased spleen weight 0.000446196514123294 0.00523615728055683 0.901093870700096 0.608695652173913 7.2 7 2 abnormal lymphocyte physiology 0.00386180184524614 0.0293768565444947 0.901093870700096 0.608695652173913 7.2 7 2 fragile skeleton 0.0373905637810004 0.158817005639851 0.901093870700096 0.608695652173913 7.2 7 2 abnormal pulmonary artery morphology 0.0373905637810004 0.158817005639851 0.901093870700096 0.608695652173913 7.2 7 2 abnormal carpal bone morphology 0.0373905637810004 0.158817005639851 0.901093870700096 0.608695652173913 7.2 7 2 blistering 0.0373905637810004 0.158817005639851 0.901093870700096 0.608695652173913 7.2 7 2 abnormal circulating insulin level 0.0373905637810004 0.158817005639851 0.901093870700096 0.608695652173913 7.2 7 2 failure of embryo implantation 0.0373905637810004 0.158817005639851 0.901093870700096 0.608695652173913 7.2 7 2 abnormal nasal cavity morphology 0.0373905637810004 0.158817005639851 0.901093870700096 0.608695652173913 7.2 7 2 abnormal palatal shelf fusion at midline 0.0373905637810004 0.158817005639851 0.901093870700096 0.608695652173913 7.2 7 2 impaired hematopoiesis 0.00249442791535275 0.0209979338052114 0.899831834466623 0.607843137254902 7.2 7 2 small lung 0.00249442791535275 0.0209979338052114 0.899831834466623 0.607843137254902 7.2 7 2 decreased food intake 0.000191319909067647 0.00256528012502196 0.899464406196118 0.607594936708861 7.2 7 2 abnormal neuron differentiation 1.02193259667887e-05 0.000194793665458903 0.89879516184627 0.607142857142857 7.2 7 2 rib bifurcation 0.0233253543903001 0.115370539329622 0.89879516184627 0.607142857142857 7.2 7 2 increased bone resorption 0.0233253543903001 0.115370539329622 0.89879516184627 0.607142857142857 7.2 7 2 hypoxia 0.0233253543903001 0.115370539329622 0.89879516184627 0.607142857142857 7.2 7 2 improved glucose tolerance 6.16438496478102e-09 2.27169001479893e-07 0.89879516184627 0.607142857142857 7.2 7 2 abnormal long bone morphology 0.00105101676532138 0.0106493042922074 0.897928435557122 0.60655737704918 7.2 7 2 dilated heart atrium 0.0147161725979555 0.081632374638699 0.897193031432996 0.606060606060606 7.2 7 2 single kidney 0.0147161725979555 0.081632374638699 0.897193031432996 0.606060606060606 7.2 7 2 abnormal QRS complex 0.0147161725979555 0.081632374638699 0.897193031432996 0.606060606060606 7.2 7 2 abnormal axial skeleton morphology 0.000292641497547854 0.00370455839771138 0.896012514286374 0.605263157894737 7.2 7 2 increased bone marrow cell number 0.00936204434980145 0.0573598160594362 0.896012514286374 0.605263157894737 7.2 7 2 impaired branching involved in ureteric bud morphogenesis 0.00936204434980145 0.0573598160594362 0.896012514286374 0.605263157894737 7.2 7 2 hyporesponsive to tactile stimuli 0.00936204434980145 0.0573598160594362 0.896012514286374 0.605263157894737 7.2 7 2 abnormal vasculogenesis 0.0059940326471934 0.0408497430408043 0.895106536011059 0.604651162790698 7.2 7 2 abnormal blood circulation 0.0059940326471934 0.0408497430408043 0.895106536011059 0.604651162790698 7.2 7 2 delayed endochondral bone ossification 0.0059940326471934 0.0408497430408043 0.895106536011059 0.604651162790698 7.2 7 2 small ovary 8.26947234355908e-05 0.00122079005665301 0.894728215412576 0.604395604395604 7.2 7 2 abnormal B cell differentiation 8.26947234355908e-05 0.00122079005665301 0.894728215412576 0.604395604395604 7.2 7 2 increased susceptibility to pharmacologically induced seizures 5.43982258326837e-05 0.000848373584694676 0.894389303209768 0.604166666666667 7.2 7 2 short tail 0.000191815920906164 0.00256528012502196 0.891788254135207 0.602409638554217 7.2 7 2 increased spleen weight 1.55822868433463e-05 0.000278855672826071 0.890841222360904 0.601769911504425 7.2 7 2 abnormal cardiovascular system physiology 2.97022047728529e-06 6.50962417378604e-05 0.890447219166583 0.601503759398496 7.2 7 2 abnormal rostral-caudal axis patterning 0.00248246276851216 0.0209979338052114 0.888221101118666 0.6 7.2 7 2 abnormal retina morphology 6.27653111014018e-09 2.29601046124613e-07 0.888221101118666 0.6 7.2 7 2 abnormal neurocranium morphology 0.000446257424513788 0.00523615728055683 0.888221101118666 0.6 7.2 7 2 abnormal axon extension 0.00383945808135853 0.029341480729276 0.888221101118666 0.6 7.2 7 2 irregular heartbeat 0.00596172592978125 0.0407972303998098 0.888221101118666 0.6 7.2 7 2 cardiomyopathy 0.00596172592978125 0.0407972303998098 0.888221101118666 0.6 7.2 7 2 gastrointestinal hemorrhage 0.0231010506820393 0.115042769913059 0.888221101118666 0.6 7.2 7 2 abnormal brain vasculature morphology 0.0231010506820393 0.115042769913059 0.888221101118666 0.6 7.2 7 2 decreased placenta weight 0.0369314036429229 0.158817005639851 0.888221101118666 0.6 7.2 7 2 abnormal cell proliferation 0.0599192202588395 0.222206873386174 0.888221101118666 0.6 7.2 7 2 abnormal male reproductive system physiology 0.0599192202588395 0.222206873386174 0.888221101118666 0.6 7.2 7 2 abnormal thymocyte activation 0.0599192202588395 0.222206873386174 0.888221101118666 0.6 7.2 7 2 abnormal heart right ventricle morphology 0.0599192202588395 0.222206873386174 0.888221101118666 0.6 7.2 7 2 dilated vasculature 0.0599192202588395 0.222206873386174 0.888221101118666 0.6 7.2 7 2 decreased circulating VLDL cholesterol level 0.0599192202588395 0.222206873386174 0.888221101118666 0.6 7.2 7 2 abnormal induced retinal neovascularization 0.0599192202588395 0.222206873386174 0.888221101118666 0.6 7.2 7 2 enhanced behavioral response to xenobiotic 0.0599192202588395 0.222206873386174 0.888221101118666 0.6 7.2 7 2 abnormal heart electrocardiography waveform feature 0.0599192202588395 0.222206873386174 0.888221101118666 0.6 7.2 7 2 macrocytosis 0.0994277691699634 0.308003207733853 0.888221101118666 0.6 7.2 7 2 abnormal apical ectodermal ridge morphology 0.0994277691699634 0.308003207733853 0.888221101118666 0.6 7.2 7 2 placental labyrinth hypoplasia 0.0994277691699634 0.308003207733853 0.888221101118666 0.6 7.2 7 2 arthritis 0.0994277691699634 0.308003207733853 0.888221101118666 0.6 7.2 7 2 abnormal energy homeostasis 0.0994277691699634 0.308003207733853 0.888221101118666 0.6 7.2 7 2 absent chorion 0.0994277691699634 0.308003207733853 0.888221101118666 0.6 7.2 7 2 abnormal aorta wall morphology 0.0994277691699634 0.308003207733853 0.888221101118666 0.6 7.2 7 2 retarded hair growth 0.171546857208497 0.414963905812287 0.888221101118666 0.6 7.2 7 2 increased cranium width 0.171546857208497 0.414963905812287 0.888221101118666 0.6 7.2 7 2 small petrosal ganglion 0.171546857208497 0.414963905812287 0.888221101118666 0.6 7.2 7 2 abnormal prostate gland epithelium morphology 0.171546857208497 0.414963905812287 0.888221101118666 0.6 7.2 7 2 abnormal immune cell physiology 0.171546857208497 0.414963905812287 0.888221101118666 0.6 7.2 7 2 rhinitis 0.171546857208497 0.414963905812287 0.888221101118666 0.6 7.2 7 2 alcohol preference 0.171546857208497 0.414963905812287 0.888221101118666 0.6 7.2 7 2 abnormal neuron specification 0.171546857208497 0.414963905812287 0.888221101118666 0.6 7.2 7 2 impaired basement membrane formation 0.171546857208497 0.414963905812287 0.888221101118666 0.6 7.2 7 2 aneurysm 0.171546857208497 0.414963905812287 0.888221101118666 0.6 7.2 7 2 intestinal hypoperistalsis 0.171546857208497 0.414963905812287 0.888221101118666 0.6 7.2 7 2 peritoneal inflammation 0.171546857208497 0.414963905812287 0.888221101118666 0.6 7.2 7 2 bifid ureter 0.171546857208497 0.414963905812287 0.888221101118666 0.6 7.2 7 2 increased left ventricle diastolic pressure 0.171546857208497 0.414963905812287 0.888221101118666 0.6 7.2 7 2 increased defecation amount 0.171546857208497 0.414963905812287 0.888221101118666 0.6 7.2 7 2 increased heart rate variability 0.171546857208497 0.414963905812287 0.888221101118666 0.6 7.2 7 2 abnormal reproductive system development 0.171546857208497 0.414963905812287 0.888221101118666 0.6 7.2 7 2 abnormal deltoid tuberosity morphology 0.171546857208497 0.414963905812287 0.888221101118666 0.6 7.2 7 2 abnormal gonadal fat pad morphology 0.171546857208497 0.414963905812287 0.888221101118666 0.6 7.2 7 2 vascular smooth muscle hyperplasia 0.171546857208497 0.414963905812287 0.888221101118666 0.6 7.2 7 2 increased platelet aggregation 0.171546857208497 0.414963905812287 0.888221101118666 0.6 7.2 7 2 impaired behavioral response to morphine 0.171546857208497 0.414963905812287 0.888221101118666 0.6 7.2 7 2 protruding tongue 0.171546857208497 0.414963905812287 0.888221101118666 0.6 7.2 7 2 umbilical hernia 0.171546857208497 0.414963905812287 0.888221101118666 0.6 7.2 7 2 increased kidney iron level 0.171546857208497 0.414963905812287 0.888221101118666 0.6 7.2 7 2 common ventricle 0.171546857208497 0.414963905812287 0.888221101118666 0.6 7.2 7 2 sinus bradycardia 0.171546857208497 0.414963905812287 0.888221101118666 0.6 7.2 7 2 decreased macrophage cytokine production 0.171546857208497 0.414963905812287 0.888221101118666 0.6 7.2 7 2 impaired adaptive thermogenesis 0.0146018400251247 0.0815310371773235 0.888221101118666 0.6 7.2 7 2 increased body weight 2.76536365865844e-09 1.15610791611981e-07 0.885577585936766 0.598214285714286 7.2 7 2 kinked tail 5.42044721173931e-05 0.000848010216301983 0.885318417781677 0.598039215686274 7.2 7 2 sparse hair 0.000290930890326912 0.00369229892698057 0.88461044623607 0.597560975609756 7.2 7 2 abnormal heart left ventricle morphology 0.000679737580194765 0.00733556282314307 0.884108966391265 0.597222222222222 7.2 7 2 abnormal lung morphology 1.54791977985071e-05 0.000278010862987627 0.883245072540971 0.596638655462185 7.2 7 2 abnormal craniofacial bone morphology 0.00246590454668736 0.0208992761835939 0.883026825673528 0.596491228070175 7.2 7 2 perinatal lethality, complete penetrance 9.3756905568945e-09 3.38000438554711e-07 0.882661031628096 0.596244131455399 7.2 7 2 decreased kidney weight 0.00381045987288817 0.0292096115063461 0.882527376111496 0.596153846153846 7.2 7 2 respiratory failure 1.29063036651966e-06 3.02871984596004e-05 0.882338842170861 0.596026490066225 7.2 7 2 decreased hematocrit 1.94876209636663e-06 4.46778406885899e-05 0.882137394946621 0.595890410958904 7.2 7 2 decreased bone trabecula number 0.00591023932319272 0.0407699365031367 0.881921660685201 0.595744680851064 7.2 7 2 abnormal cartilage morphology 0.00920898551145728 0.0570544245572852 0.881171727300264 0.595238095238095 7.2 7 2 abnormal muscle morphology 0.00920898551145728 0.0570544245572852 0.881171727300264 0.595238095238095 7.2 7 2 decreased B cell proliferation 0.000441536945395811 0.00520532299370654 0.880725564400365 0.594936708860759 7.2 7 2 abnormal angiogenesis 0.000675102675531316 0.00731728934807907 0.880219109216696 0.594594594594595 7.2 7 2 abnormal intestine morphology 0.000675102675531316 0.00731728934807907 0.880219109216696 0.594594594594595 7.2 7 2 increased circulating phosphate level 0.0144303371396897 0.0807546988413455 0.880219109216696 0.594594594594595 7.2 7 2 decreased circulating chloride level 0.0144303371396897 0.0807546988413455 0.880219109216696 0.594594594594595 7.2 7 2 abnormal humerus morphology 0.0144303371396897 0.0807546988413455 0.880219109216696 0.594594594594595 7.2 7 2 abnormal osteoclast physiology 0.00158762603716571 0.0150446467331418 0.878968797982014 0.59375 7.2 7 2 abnormal vertebral body morphology 0.0227758299565293 0.114454297003771 0.878968797982014 0.59375 7.2 7 2 polydipsia 0.0227758299565293 0.114454297003771 0.878968797982014 0.59375 7.2 7 2 abnormal heart atrium morphology 0.0227758299565293 0.114454297003771 0.878968797982014 0.59375 7.2 7 2 increased fatty acid level 0.0227758299565293 0.114454297003771 0.878968797982014 0.59375 7.2 7 2 abnormal serotonin level 0.0227758299565293 0.114454297003771 0.878968797982014 0.59375 7.2 7 2 increased B cell proliferation 0.0024434292878021 0.0207560056992116 0.878184704495857 0.593220338983051 7.2 7 2 increased hemoglobin content 0.0024434292878021 0.0207560056992116 0.878184704495857 0.593220338983051 7.2 7 2 increased leukocyte cell number 2.91166046106965e-06 6.40951805036351e-05 0.878011663174774 0.593103448275862 7.2 7 2 abnormal mandible morphology 0.00377167643164725 0.0290465793304103 0.877255408512263 0.592592592592593 7.2 7 2 polyphagia 0.00377167643164725 0.0290465793304103 0.877255408512263 0.592592592592593 7.2 7 2 abnormal osteoblast physiology 0.00377167643164725 0.0290465793304103 0.877255408512263 0.592592592592593 7.2 7 2 abnormal trigeminal ganglion morphology 0.036291303785421 0.157135975920339 0.877255408512263 0.592592592592593 7.2 7 2 thick interventricular septum 0.036291303785421 0.157135975920339 0.877255408512263 0.592592592592593 7.2 7 2 abnormal bone trabecula morphology 0.036291303785421 0.157135975920339 0.877255408512263 0.592592592592593 7.2 7 2 abnormal definitive hematopoiesis 0.000186864546831507 0.0025262258708879 0.875486748414456 0.591397849462366 7.2 7 2 no abnormal phenotype detected 3.22167084470226e-59 5.34260415079791e-56 0.875422526174593 0.59135446685879 7.2 7 2 abnormal circadian rhythm 0.00908867610456545 0.0565202045252664 0.874763205647172 0.590909090909091 7.2 7 2 abnormal myelopoiesis 0.00908867610456545 0.0565202045252664 0.874763205647172 0.590909090909091 7.2 7 2 renal interstitial fibrosis 0.00908867610456545 0.0565202045252664 0.874763205647172 0.590909090909091 7.2 7 2 abnormal amino acid level 0.00908867610456545 0.0565202045252664 0.874763205647172 0.590909090909091 7.2 7 2 abnormal long bone epiphysis morphology 0.0585910350050802 0.222206873386174 0.874763205647172 0.590909090909091 7.2 7 2 abnormal chorion morphology 0.0585910350050802 0.222206873386174 0.874763205647172 0.590909090909091 7.2 7 2 prolonged PR interval 0.0585910350050802 0.222206873386174 0.874763205647172 0.590909090909091 7.2 7 2 abnormal basement membrane morphology 0.0585910350050802 0.222206873386174 0.874763205647172 0.590909090909091 7.2 7 2 abnormal occipital bone morphology 0.0585910350050802 0.222206873386174 0.874763205647172 0.590909090909091 7.2 7 2 increased circulating creatine kinase level 0.0585910350050802 0.222206873386174 0.874763205647172 0.590909090909091 7.2 7 2 rough coat 0.0585910350050802 0.222206873386174 0.874763205647172 0.590909090909091 7.2 7 2 increased bone volume 0.0585910350050802 0.222206873386174 0.874763205647172 0.590909090909091 7.2 7 2 reduced female fertility 5.99053882786416e-09 2.24069360950691e-07 0.874183123945814 0.59051724137931 7.2 7 2 female infertility 5.11705948534156e-10 2.76710553691025e-08 0.873751333807209 0.590225563909774 7.2 7 2 increased osteoclast cell number 0.00241579785097714 0.0207560056992116 0.873660099460983 0.590163934426229 7.2 7 2 decreased heart rate 0.00012173500463827 0.0017175943159871 0.873417416100022 0.59 7.2 7 2 absent gastric milk in neonates 0.000662303698487996 0.00731728934807907 0.873037834432877 0.58974358974359 7.2 7 2 acanthosis 0.0142126582569923 0.0799863968648606 0.873037834432877 0.58974358974359 7.2 7 2 decreased B-1 B cell number 0.0142126582569923 0.0799863968648606 0.873037834432877 0.58974358974359 7.2 7 2 abnormal seminal vesicle morphology 0.00372448943114107 0.0288170060963092 0.872360010027262 0.589285714285714 7.2 7 2 increased T cell proliferation 7.93729452251998e-05 0.00117874747013543 0.871618837546355 0.588785046728972 7.2 7 2 abnormal kidney morphology 5.40533714955987e-07 1.38170766241722e-05 0.871302603954501 0.588571428571429 7.2 7 2 cochlear inner hair cell degeneration 0.00576092974708112 0.0399173056987863 0.870805001096732 0.588235294117647 7.2 7 2 abnormal brown adipose tissue morphology 0.0223722304782866 0.11384100064078 0.870805001096732 0.588235294117647 7.2 7 2 decreased vasoconstriction 0.0964398159135615 0.306769874788983 0.870805001096732 0.588235294117647 7.2 7 2 abnormal testis development 0.0964398159135615 0.306769874788983 0.870805001096732 0.588235294117647 7.2 7 2 decreased growth hormone level 0.0964398159135615 0.306769874788983 0.870805001096732 0.588235294117647 7.2 7 2 increased hepatoma incidence 0.0964398159135615 0.306769874788983 0.870805001096732 0.588235294117647 7.2 7 2 abnormal electroretinogram waveform feature 0.0964398159135615 0.306769874788983 0.870805001096732 0.588235294117647 7.2 7 2 decreased body fat mass 0.0964398159135615 0.306769874788983 0.870805001096732 0.588235294117647 7.2 7 2 abnormal vertebrae morphology 7.84916644824478e-05 0.00117266075315369 0.86920719375527 0.587155963302752 7.2 7 2 dermatitis 0.00367013916706356 0.0284407201809053 0.867802225230881 0.586206896551724 7.2 7 2 thrombocytosis 0.00367013916706356 0.0284407201809053 0.867802225230881 0.586206896551724 7.2 7 2 lordosis 0.0355184828106371 0.155276319844393 0.867802225230881 0.586206896551724 7.2 7 2 decreased retinal photoreceptor cell number 0.0355184828106371 0.155276319844393 0.867802225230881 0.586206896551724 7.2 7 2 aphagia 0.0355184828106371 0.155276319844393 0.867802225230881 0.586206896551724 7.2 7 2 decreased trophoblast giant cell number 0.0355184828106371 0.155276319844393 0.867802225230881 0.586206896551724 7.2 7 2 abnormal outer ear morphology 0.0355184828106371 0.155276319844393 0.867802225230881 0.586206896551724 7.2 7 2 abnormal CD8-positive, alpha-beta T cell physiology 0.0355184828106371 0.155276319844393 0.867802225230881 0.586206896551724 7.2 7 2 decreased bone strength 0.0355184828106371 0.155276319844393 0.867802225230881 0.586206896551724 7.2 7 2 abnormal enzyme/coenzyme activity 2.75649143422603e-06 6.12211825235469e-05 0.867477083895088 0.585987261146497 7.2 7 2 abnormal mammary gland development 0.0139580304164228 0.0787315207729063 0.866557171823089 0.585365853658537 7.2 7 2 thick ventricular wall 0.0139580304164228 0.0787315207729063 0.866557171823089 0.585365853658537 7.2 7 2 increased bone trabecula number 0.0139580304164228 0.0787315207729063 0.866557171823089 0.585365853658537 7.2 7 2 abnormal placenta development 0.00566790614575738 0.0393824484289706 0.865875916184863 0.584905660377358 7.2 7 2 abnormal pancreatic islet morphology 0.00566790614575738 0.0393824484289706 0.865875916184863 0.584905660377358 7.2 7 2 obese 0.000985558267448362 0.0101514542040489 0.865150423167532 0.584415584415584 7.2 7 2 polyuria 0.000985558267448362 0.0101514542040489 0.865150423167532 0.584415584415584 7.2 7 2 abnormal T cell differentiation 0.000178277493412627 0.00242330745827273 0.864769718910913 0.584158415841584 7.2 7 2 abnormal lymph node morphology 0.00878458221849552 0.0559872741390006 0.863548292754259 0.583333333333333 7.2 7 2 abnormal startle reflex 0.0570440090850742 0.218951202012865 0.863548292754259 0.583333333333333 7.2 7 2 abnormal primitive streak formation 0.0570440090850742 0.218951202012865 0.863548292754259 0.583333333333333 7.2 7 2 abnormal impulse conducting system conduction 0.0570440090850742 0.218951202012865 0.863548292754259 0.583333333333333 7.2 7 2 abnormal truncus arteriosus septation 0.0570440090850742 0.218951202012865 0.863548292754259 0.583333333333333 7.2 7 2 abnormal lung saccule morphology 0.0570440090850742 0.218951202012865 0.863548292754259 0.583333333333333 7.2 7 2 abnormal mineral level 0.163819936752821 0.414963905812287 0.863548292754259 0.583333333333333 7.2 7 2 mesocardia 0.163819936752821 0.414963905812287 0.863548292754259 0.583333333333333 7.2 7 2 abnormal superior cervical ganglion morphology 0.163819936752821 0.414963905812287 0.863548292754259 0.583333333333333 7.2 7 2 abnormal enteric nervous system morphology 0.163819936752821 0.414963905812287 0.863548292754259 0.583333333333333 7.2 7 2 absent optic nerve 0.163819936752821 0.414963905812287 0.863548292754259 0.583333333333333 7.2 7 2 ear inflammation 0.163819936752821 0.414963905812287 0.863548292754259 0.583333333333333 7.2 7 2 myocarditis 0.163819936752821 0.414963905812287 0.863548292754259 0.583333333333333 7.2 7 2 interstitial pneumonia 0.163819936752821 0.414963905812287 0.863548292754259 0.583333333333333 7.2 7 2 increased papilloma incidence 0.163819936752821 0.414963905812287 0.863548292754259 0.583333333333333 7.2 7 2 abnormal tracheal ciliated epithelium morphology 0.163819936752821 0.414963905812287 0.863548292754259 0.583333333333333 7.2 7 2 abnormal gastrocnemius morphology 0.163819936752821 0.414963905812287 0.863548292754259 0.583333333333333 7.2 7 2 abnormal aorta elastic fiber morphology 0.163819936752821 0.414963905812287 0.863548292754259 0.583333333333333 7.2 7 2 dilated bile duct 0.163819936752821 0.414963905812287 0.863548292754259 0.583333333333333 7.2 7 2 abnormal defecation 0.163819936752821 0.414963905812287 0.863548292754259 0.583333333333333 7.2 7 2 increased hepatocyte proliferation 0.163819936752821 0.414963905812287 0.863548292754259 0.583333333333333 7.2 7 2 abnormal fatty acid level 0.163819936752821 0.414963905812287 0.863548292754259 0.583333333333333 7.2 7 2 hemoperitoneum 0.163819936752821 0.414963905812287 0.863548292754259 0.583333333333333 7.2 7 2 reduced cerebellar foliation 0.163819936752821 0.414963905812287 0.863548292754259 0.583333333333333 7.2 7 2 abnormal behavioral response to addictive substance 0.163819936752821 0.414963905812287 0.863548292754259 0.583333333333333 7.2 7 2 impaired behavioral response to cocaine 0.163819936752821 0.414963905812287 0.863548292754259 0.583333333333333 7.2 7 2 decreased oligodendrocyte number 0.163819936752821 0.414963905812287 0.863548292754259 0.583333333333333 7.2 7 2 increased skeletal muscle glycogen level 0.163819936752821 0.414963905812287 0.863548292754259 0.583333333333333 7.2 7 2 abnormal colon goblet cell morphology 0.163819936752821 0.414963905812287 0.863548292754259 0.583333333333333 7.2 7 2 hydronephrosis 0.000636100149182919 0.00706383536202014 0.863548292754259 0.583333333333333 7.2 7 2 abnormal reflex 0.0219084543339155 0.111789292626902 0.863548292754259 0.583333333333333 7.2 7 2 abnormal limb bone morphology 0.0219084543339155 0.111789292626902 0.863548292754259 0.583333333333333 7.2 7 2 renal hypoplasia 0.0219084543339155 0.111789292626902 0.863548292754259 0.583333333333333 7.2 7 2 abnormal retinal blood vessel morphology 0.0219084543339155 0.111789292626902 0.863548292754259 0.583333333333333 7.2 7 2 abnormal skeleton morphology 7.54260137663802e-05 0.00113025427255344 0.862475561955806 0.582608695652174 7.2 7 2 increased sensitivity to xenobiotic induced morbidity/mortality 0.000114173461233822 0.00163222117712145 0.861305310175677 0.581818181818182 7.2 7 2 abnormal homeostasis 0.0136741978229349 0.0777475819075442 0.860679361549095 0.581395348837209 7.2 7 2 decreased neutrophil cell number 7.42873741120609e-05 0.00111655494322508 0.860385112194719 0.581196581196581 7.2 7 2 small seminiferous tubules 0.00148153563692647 0.0142841856467233 0.860214129461771 0.581081081081081 7.2 7 2 pale kidney 0.0346498695932588 0.152551417014569 0.859568807534193 0.580645161290323 7.2 7 2 decreased neuronal precursor cell number 0.0346498695932588 0.152551417014569 0.859568807534193 0.580645161290323 7.2 7 2 abnormal podocyte morphology 0.0346498695932588 0.152551417014569 0.859568807534193 0.580645161290323 7.2 7 2 abnormal coat/hair pigmentation 0.000112371343400266 0.0016157440272148 0.859142434117758 0.580357142857143 7.2 7 2 abnormal skeleton development 0.000953521233254005 0.00990348253745026 0.858979254168258 0.580246913580247 7.2 7 2 increased lymphocyte cell number 0.00226664132884172 0.0197834045806799 0.858184638761997 0.579710144927536 7.2 7 2 increased T cell number 0.000615190086990256 0.00687768692758769 0.857940836307803 0.579545454545455 7.2 7 2 alopecia 0.000397737825521807 0.00474519348194482 0.857055448447836 0.578947368421053 7.2 7 2 decreased neuron apoptosis 0.0213992397257861 0.110666546398946 0.857055448447836 0.578947368421053 7.2 7 2 stereotypic behavior 0.0931343838111269 0.297970134701194 0.857055448447836 0.578947368421053 7.2 7 2 decreased chemically-elicited antinociception 0.0931343838111269 0.297970134701194 0.857055448447836 0.578947368421053 7.2 7 2 abnormal ear morphology 0.0931343838111269 0.297970134701194 0.857055448447836 0.578947368421053 7.2 7 2 abnormal neural crest cell migration 0.0931343838111269 0.297970134701194 0.857055448447836 0.578947368421053 7.2 7 2 abnormal digestive system development 0.0931343838111269 0.297970134701194 0.857055448447836 0.578947368421053 7.2 7 2 absent amnion 0.0931343838111269 0.297970134701194 0.857055448447836 0.578947368421053 7.2 7 2 decreased liver regeneration 0.0931343838111269 0.297970134701194 0.857055448447836 0.578947368421053 7.2 7 2 increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 0.0931343838111269 0.297970134701194 0.857055448447836 0.578947368421053 7.2 7 2 atelectasis 0.00222241236332151 0.0194314613489007 0.854860684175242 0.577464788732394 7.2 7 2 abnormal lipid homeostasis 4.59756139834296e-05 0.000735461992178657 0.854058751075641 0.576923076923077 7.2 7 2 absent corpus luteum 0.00842066139370784 0.0541950717124146 0.854058751075641 0.576923076923077 7.2 7 2 abnormal xiphoid process morphology 0.0553550181874731 0.218045301253111 0.854058751075641 0.576923076923077 7.2 7 2 abnormal ocular fundus morphology 0.0553550181874731 0.218045301253111 0.854058751075641 0.576923076923077 7.2 7 2 decreased bone resorption 0.0553550181874731 0.218045301253111 0.854058751075641 0.576923076923077 7.2 7 2 decreased Peyer's patch number 0.0553550181874731 0.218045301253111 0.854058751075641 0.576923076923077 7.2 7 2 abnormal heart ventricle morphology 0.00142635995239432 0.0137789141032267 0.854058751075641 0.576923076923077 7.2 7 2 abnormal thoracic vertebrae morphology 0.00533846460285912 0.0374596070510919 0.853093712938832 0.576271186440678 7.2 7 2 abnormal aorta morphology 0.0337139363717364 0.14931604798101 0.852333379861346 0.575757575757576 7.2 7 2 enlarged pericardium 0.0337139363717364 0.14931604798101 0.852333379861346 0.575757575757576 7.2 7 2 belly spot 0.0337139363717364 0.14931604798101 0.852333379861346 0.575757575757576 7.2 7 2 abnormal ovarian folliculogenesis 0.0337139363717364 0.14931604798101 0.852333379861346 0.575757575757576 7.2 7 2 abnormal epidermis stratum basale morphology 0.0337139363717364 0.14931604798101 0.852333379861346 0.575757575757576 7.2 7 2 myeloid hyperplasia 0.0337139363717364 0.14931604798101 0.852333379861346 0.575757575757576 7.2 7 2 abnormal pancreatic beta cell morphology 0.0208565455024311 0.108084701952703 0.851211888572055 0.575 7.2 7 2 hepatic necrosis 0.0130438740678208 0.0746758037829785 0.850424458517872 0.574468085106383 7.2 7 2 increased neutrophil cell number 2.77196146017973e-05 0.000467474856420141 0.847383349343096 0.572413793103448 7.2 7 2 increased blood urea nitrogen level 2.77196146017973e-05 0.000467474856420141 0.847383349343096 0.572413793103448 7.2 7 2 abnormal hair follicle morphology 0.00509169196263605 0.0360842842081401 0.845924858208254 0.571428571428571 7.2 7 2 abnormal respiratory system physiology 0.0127074156610196 0.0737682531080192 0.845924858208254 0.571428571428571 7.2 7 2 skin edema 0.0202900902897101 0.105783945593103 0.845924858208254 0.571428571428571 7.2 7 2 abnormal renal tubule epithelium morphology 0.0535792363122488 0.212226672494775 0.845924858208254 0.571428571428571 7.2 7 2 abnormal scapula morphology 0.0896710964783323 0.288373435668845 0.845924858208254 0.571428571428571 7.2 7 2 megacephaly 0.15597426676741 0.414963905812287 0.845924858208254 0.571428571428571 7.2 7 2 irregularly shaped pupil 0.15597426676741 0.414963905812287 0.845924858208254 0.571428571428571 7.2 7 2 abnormal pinna reflex 0.15597426676741 0.414963905812287 0.845924858208254 0.571428571428571 7.2 7 2 extended life span 0.15597426676741 0.414963905812287 0.845924858208254 0.571428571428571 7.2 7 2 abnormal adrenal gland secretion 0.15597426676741 0.414963905812287 0.845924858208254 0.571428571428571 7.2 7 2 abnormal spleen periarteriolar lymphoid sheath morphology 0.15597426676741 0.414963905812287 0.845924858208254 0.571428571428571 7.2 7 2 abnormal endplate potential 0.15597426676741 0.414963905812287 0.845924858208254 0.571428571428571 7.2 7 2 abnormal sagittal suture morphology 0.15597426676741 0.414963905812287 0.845924858208254 0.571428571428571 7.2 7 2 abnormal decidualization 0.15597426676741 0.414963905812287 0.845924858208254 0.571428571428571 7.2 7 2 abnormal maternal decidual layer morphology 0.15597426676741 0.414963905812287 0.845924858208254 0.571428571428571 7.2 7 2 premature hair loss 0.15597426676741 0.414963905812287 0.845924858208254 0.571428571428571 7.2 7 2 abnormal renal reabsorbtion 0.15597426676741 0.414963905812287 0.845924858208254 0.571428571428571 7.2 7 2 decreased response to antigen 0.15597426676741 0.414963905812287 0.845924858208254 0.571428571428571 7.2 7 2 abnormal enzyme/coenzyme level 0.00781111756113074 0.0509309434687096 0.842278630371149 0.568965517241379 7.2 7 2 abnormal renal glomerulus morphology 0.000343385433137414 0.0042106887205158 0.842044468950418 0.568807339449541 7.2 7 2 distended abdomen 0.0123621233334079 0.0723269644412549 0.841778167726841 0.568627450980392 7.2 7 2 small kidney 0.00127337792048508 0.0126955013114494 0.841118466968434 0.568181818181818 7.2 7 2 malocclusion 0.0317234831513365 0.1424407298537 0.840209149706847 0.567567567567568 7.2 7 2 rib fusion 0.0048337891045377 0.0344035776753577 0.839611986132073 0.567164179104478 7.2 7 2 abnormal long bone epiphyseal plate morphology 0.00759911008525737 0.0499413113264933 0.838875484389852 0.566666666666667 7.2 7 2 abnormal incisor morphology 0.00759911008525737 0.0499413113264933 0.838875484389852 0.566666666666667 7.2 7 2 abnormal hair cycle 0.0517566632864959 0.20541193136329 0.838875484389852 0.566666666666667 7.2 7 2 increased metastatic potential 0.0517566632864959 0.20541193136329 0.838875484389852 0.566666666666667 7.2 7 2 abnormal fat pad morphology 0.0517566632864959 0.20541193136329 0.838875484389852 0.566666666666667 7.2 7 2 abnormal forelimb morphology 0.0191160421257278 0.102041104694738 0.836730022792947 0.565217391304348 7.2 7 2 abnormal sacral vertebrae morphology 0.0861516475963841 0.286500298657761 0.836730022792947 0.565217391304348 7.2 7 2 decreased epididymis weight 0.0861516475963841 0.286500298657761 0.836730022792947 0.565217391304348 7.2 7 2 abnormal basicranium morphology 0.0861516475963841 0.286500298657761 0.836730022792947 0.565217391304348 7.2 7 2 abnormal hepatocyte physiology 0.0861516475963841 0.286500298657761 0.836730022792947 0.565217391304348 7.2 7 2 decreased effector memory CD8-positive, alpha-beta T cell number 0.0861516475963841 0.286500298657761 0.836730022792947 0.565217391304348 7.2 7 2 increased urine protein level 0.00292576772643913 0.0241928935893944 0.835079667718404 0.564102564102564 7.2 7 2 increased autoantibody level 0.0306995216265782 0.138278349809835 0.835079667718404 0.564102564102564 7.2 7 2 abnormal circulating hormone level 0.0306995216265782 0.138278349809835 0.835079667718404 0.564102564102564 7.2 7 2 decreased trabecular bone volume 0.0306995216265782 0.138278349809835 0.835079667718404 0.564102564102564 7.2 7 2 short limbs 0.00182793963196381 0.0165646624208013 0.833770765417905 0.563218390804598 7.2 7 2 vasculature congestion 0.148272834049041 0.414963905812287 0.83270728229875 0.5625 7.2 7 2 mixed cellular infiltration to dermis 0.148272834049041 0.414963905812287 0.83270728229875 0.5625 7.2 7 2 poor circulation 0.148272834049041 0.414963905812287 0.83270728229875 0.5625 7.2 7 2 increased pancreatic beta cell number 0.148272834049041 0.414963905812287 0.83270728229875 0.5625 7.2 7 2 increased thymus weight 0.148272834049041 0.414963905812287 0.83270728229875 0.5625 7.2 7 2 abnormal Langerhans cell physiology 0.148272834049041 0.414963905812287 0.83270728229875 0.5625 7.2 7 2 abnormal thoracic cage shape 0.148272834049041 0.414963905812287 0.83270728229875 0.5625 7.2 7 2 abnormal pulmonary alveolus wall morphology 0.148272834049041 0.414963905812287 0.83270728229875 0.5625 7.2 7 2 embryonic lethality between somite formation and embryo turning, incomplete penetrance 0.148272834049041 0.414963905812287 0.83270728229875 0.5625 7.2 7 2 decreased midbrain size 0.148272834049041 0.414963905812287 0.83270728229875 0.5625 7.2 7 2 abnormal blood homeostasis 0.000454159612526921 0.00531633899369749 0.831084071222144 0.56140350877193 7.2 7 2 abnormal circulating amino acid level 0.0113028380951135 0.0670052535894201 0.831084071222144 0.56140350877193 7.2 7 2 hemopericardium 0.0296713147789974 0.135426413784873 0.830450622997127 0.560975609756098 7.2 7 2 abnormal cholesterol homeostasis 0.0296713147789974 0.135426413784873 0.830450622997127 0.560975609756098 7.2 7 2 increased thermal nociceptive threshold 0.00172711540314934 0.0159658775225234 0.82965707247348 0.56043956043956 7.2 7 2 delayed bone ossification 0.00430937937079377 0.0311163459647301 0.829006361044089 0.56 7.2 7 2 abnormal limb morphology 0.00430937937079377 0.0311163459647301 0.829006361044089 0.56 7.2 7 2 increased circulating chloride level 0.0179242130192433 0.0966120907591931 0.829006361044089 0.56 7.2 7 2 testicular atrophy 0.0179242130192433 0.0966120907591931 0.829006361044089 0.56 7.2 7 2 decreased oocyte number 0.0179242130192433 0.0966120907591931 0.829006361044089 0.56 7.2 7 2 impaired conditioned place preference behavior 0.0826418705569028 0.276491799610351 0.829006361044089 0.56 7.2 7 2 decreased circulating alanine transaminase level 0.00674385716183447 0.0448538628076558 0.827264751041895 0.558823529411765 7.2 7 2 overexpanded pulmonary alveoli 0.0480800971701063 0.196225170977259 0.827264751041895 0.558823529411765 7.2 7 2 decreased B cell number 4.73044468010532e-06 9.76512957822571e-05 0.826419309293258 0.558252427184466 7.2 7 2 abnormal snout morphology 0.0173317927356384 0.0937235531084794 0.825590126039786 0.557692307692308 7.2 7 2 abnormal skin condition 0.0173317927356384 0.0937235531084794 0.825590126039786 0.557692307692308 7.2 7 2 impaired fertilization 0.00653301567058059 0.0435097094526619 0.824776736753047 0.557142857142857 7.2 7 2 cochlear outer hair cell degeneration 0.00632477567257954 0.0421793015698166 0.822426945480247 0.555555555555556 7.2 7 2 skin lesions 0.0102522230259067 0.0622009872608363 0.822426945480247 0.555555555555556 7.2 7 2 abnormal cartilage development 0.0276329271276228 0.126587304290906 0.822426945480247 0.555555555555556 7.2 7 2 abnormal ovarian follicle morphology 0.0276329271276228 0.126587304290906 0.822426945480247 0.555555555555556 7.2 7 2 abnormal uterus morphology 0.046263122018236 0.18896472252933 0.822426945480247 0.555555555555556 7.2 7 2 abnormal stomach glandular epithelium morphology 0.140839618173742 0.409513208892089 0.822426945480247 0.555555555555556 7.2 7 2 abnormal mammary gland morphology 0.140839618173742 0.409513208892089 0.822426945480247 0.555555555555556 7.2 7 2 absent spleen 0.140839618173742 0.409513208892089 0.822426945480247 0.555555555555556 7.2 7 2 abnormal white adipose tissue morphology 0.140839618173742 0.409513208892089 0.822426945480247 0.555555555555556 7.2 7 2 increased circulating glycerol level 0.140839618173742 0.409513208892089 0.822426945480247 0.555555555555556 7.2 7 2 abnormal neutrophil morphology 0.140839618173742 0.409513208892089 0.822426945480247 0.555555555555556 7.2 7 2 increased susceptibility to autoimmune disorder 0.140839618173742 0.409513208892089 0.822426945480247 0.555555555555556 7.2 7 2 abnormal glycogen homeostasis 0.140839618173742 0.409513208892089 0.822426945480247 0.555555555555556 7.2 7 2 decreased tumor latency 0.140839618173742 0.409513208892089 0.822426945480247 0.555555555555556 7.2 7 2 distorted hair follicle pattern 0.273195528575077 0.584831219733652 0.822426945480247 0.555555555555556 7.2 7 2 small nodose ganglion 0.273195528575077 0.584831219733652 0.822426945480247 0.555555555555556 7.2 7 2 abnormal postural reflex 0.273195528575077 0.584831219733652 0.822426945480247 0.555555555555556 7.2 7 2 enlarged otoliths 0.273195528575077 0.584831219733652 0.822426945480247 0.555555555555556 7.2 7 2 abnormal abdominal wall morphology 0.273195528575077 0.584831219733652 0.822426945480247 0.555555555555556 7.2 7 2 pancreas cysts 0.273195528575077 0.584831219733652 0.822426945480247 0.555555555555556 7.2 7 2 abnormal ovary physiology 0.273195528575077 0.584831219733652 0.822426945480247 0.555555555555556 7.2 7 2 decreased vestibular hair cell number 0.273195528575077 0.584831219733652 0.822426945480247 0.555555555555556 7.2 7 2 abnormal hair cell mechanoelectric transduction 0.273195528575077 0.584831219733652 0.822426945480247 0.555555555555556 7.2 7 2 decreased thyroid-stimulating hormone level 0.273195528575077 0.584831219733652 0.822426945480247 0.555555555555556 7.2 7 2 hemothorax 0.273195528575077 0.584831219733652 0.822426945480247 0.555555555555556 7.2 7 2 abnormal oxygen consumption 0.273195528575077 0.584831219733652 0.822426945480247 0.555555555555556 7.2 7 2 eye opacity 0.273195528575077 0.584831219733652 0.822426945480247 0.555555555555556 7.2 7 2 prolonged RR interval 0.273195528575077 0.584831219733652 0.822426945480247 0.555555555555556 7.2 7 2 decreased airway resistance 0.273195528575077 0.584831219733652 0.822426945480247 0.555555555555556 7.2 7 2 increased core body temperature 0.273195528575077 0.584831219733652 0.822426945480247 0.555555555555556 7.2 7 2 enhanced leukocyte tethering or rolling 0.273195528575077 0.584831219733652 0.822426945480247 0.555555555555556 7.2 7 2 increased B cell number 0.000605288335731813 0.00679591437587849 0.822426945480247 0.555555555555556 7.2 7 2 abnormal small intestine morphology 0.016745608836902 0.0907509847097904 0.822426945480247 0.555555555555556 7.2 7 2 abnormal type II pneumocyte morphology 0.0791846611900384 0.2656397096564 0.822426945480247 0.555555555555556 7.2 7 2 abnormal palate morphology 0.0791846611900384 0.2656397096564 0.822426945480247 0.555555555555556 7.2 7 2 decreased litter size 1.73904940275398e-07 4.94386901640061e-06 0.821841588223677 0.555160142348754 7.2 7 2 weight loss 3.68600788958397e-05 0.000607214875850339 0.820547112462006 0.554285714285714 7.2 7 2 abnormal lipid level 0.00380032698209333 0.0291768931109789 0.820445193804391 0.55421686746988 7.2 7 2 pulmonary hypoplasia 0.0266339644831365 0.122236137733952 0.818927256350544 0.553191489361702 7.2 7 2 abnormal innervation 0.0266339644831365 0.122236137733952 0.818927256350544 0.553191489361702 7.2 7 2 increased circulating glucose level 0.000220365565499108 0.00290800713092325 0.818927256350543 0.553191489361702 7.2 7 2 abnormal reproductive system physiology 0.0444769603240754 0.181818305351089 0.818098382609298 0.552631578947368 7.2 7 2 glomerulosclerosis 0.0156003402907846 0.0862352143851705 0.816755035511417 0.551724137931034 7.2 7 2 abnormal microglial cell morphology 0.0758078560065402 0.254827083535498 0.816755035511417 0.551724137931034 7.2 7 2 abnormal dendritic cell physiology 0.00134837118085024 0.0133362755958845 0.816277958971983 0.551401869158878 7.2 7 2 decreased circulating creatinine level 0.0256538633174171 0.12144713396162 0.815713256129387 0.551020408163265 7.2 7 2 abnormal coat appearance 0.00924579851704012 0.057113270699069 0.815275406823897 0.550724637681159 7.2 7 2 abnormal hair texture 0.133730694819478 0.392050799485506 0.814202676025444 0.55 7.2 7 2 abnormal trachea morphology 0.133730694819478 0.392050799485506 0.814202676025444 0.55 7.2 7 2 absent placental labyrinth 0.133730694819478 0.392050799485506 0.814202676025444 0.55 7.2 7 2 kidney atrophy 0.133730694819478 0.392050799485506 0.814202676025444 0.55 7.2 7 2 decreased IgG level 0.00126240154663644 0.0126113407520407 0.813535843366947 0.54954954954955 7.2 7 2 abnormal cervical vertebrae morphology 0.024695452636782 0.12140304038339 0.81275133435695 0.549019607843137 7.2 7 2 increased kidney weight 0.024695452636782 0.12140304038339 0.81275133435695 0.549019607843137 7.2 7 2 decreased double-negative T cell number 0.0725291984854266 0.244301125568719 0.811814984893405 0.548387096774194 7.2 7 2 increased inflammatory response 0.00310321575217602 0.0249813889434882 0.81030696944159 0.547368421052632 7.2 7 2 decreased T cell proliferation 0.000269172086378244 0.00346028715692962 0.810201680074459 0.547297297297297 7.2 7 2 abnormal eye electrophysiology 0.00106517561367554 0.0107708306464143 0.807473728289697 0.545454545454545 7.2 7 2 increased liver weight 0.00479750793783696 0.0341942721930356 0.807473728289697 0.545454545454545 7.2 7 2 increased circulating calcium level 0.0228514966426054 0.114603019956615 0.807473728289697 0.545454545454545 7.2 7 2 decreased circulating calcium level 0.0228514966426054 0.114603019956615 0.807473728289697 0.545454545454545 7.2 7 2 increased body size 0.126967170246235 0.373764302943797 0.807473728289697 0.545454545454545 7.2 7 2 increased activated T cell number 0.126967170246235 0.373764302943797 0.807473728289697 0.545454545454545 7.2 7 2 abnormal oogenesis 0.126967170246235 0.373764302943797 0.807473728289697 0.545454545454545 7.2 7 2 increased skin papilloma incidence 0.126967170246235 0.373764302943797 0.807473728289697 0.545454545454545 7.2 7 2 abnormal cochlear sensory epithelium morphology 0.126967170246235 0.373764302943797 0.807473728289697 0.545454545454545 7.2 7 2 abnormal circulating lipid level 0.126967170246235 0.373764302943797 0.807473728289697 0.545454545454545 7.2 7 2 decreased circulating estradiol level 0.126967170246235 0.373764302943797 0.807473728289697 0.545454545454545 7.2 7 2 premature suture closure 0.253503608693068 0.550013280962937 0.807473728289697 0.545454545454545 7.2 7 2 abnormal stomach epithelium morphology 0.253503608693068 0.550013280962937 0.807473728289697 0.545454545454545 7.2 7 2 abnormal large intestine morphology 0.253503608693068 0.550013280962937 0.807473728289697 0.545454545454545 7.2 7 2 focal hepatic necrosis 0.253503608693068 0.550013280962937 0.807473728289697 0.545454545454545 7.2 7 2 abnormal larynx morphology 0.253503608693068 0.550013280962937 0.807473728289697 0.545454545454545 7.2 7 2 abnormal bronchiole morphology 0.253503608693068 0.550013280962937 0.807473728289697 0.545454545454545 7.2 7 2 abnormal vestibular ganglion morphology 0.253503608693068 0.550013280962937 0.807473728289697 0.545454545454545 7.2 7 2 retinal detachment 0.253503608693068 0.550013280962937 0.807473728289697 0.545454545454545 7.2 7 2 abnormal pituitary gland development 0.253503608693068 0.550013280962937 0.807473728289697 0.545454545454545 7.2 7 2 enlarged placenta 0.253503608693068 0.550013280962937 0.807473728289697 0.545454545454545 7.2 7 2 abnormal platelet aggregation 0.253503608693068 0.550013280962937 0.807473728289697 0.545454545454545 7.2 7 2 abnormal palate development 0.253503608693068 0.550013280962937 0.807473728289697 0.545454545454545 7.2 7 2 palatal shelf hypoplasia 0.253503608693068 0.550013280962937 0.807473728289697 0.545454545454545 7.2 7 2 decreased palatine bone horizontal plate size 0.253503608693068 0.550013280962937 0.807473728289697 0.545454545454545 7.2 7 2 increased number of Howell-Jolly bodies 0.253503608693068 0.550013280962937 0.807473728289697 0.545454545454545 7.2 7 2 common atrioventricular valve 0.253503608693068 0.550013280962937 0.807473728289697 0.545454545454545 7.2 7 2 abnormal brain ependyma motile cilium morphology 0.253503608693068 0.550013280962937 0.807473728289697 0.545454545454545 7.2 7 2 decreased embryonic cilium length 0.253503608693068 0.550013280962937 0.807473728289697 0.545454545454545 7.2 7 2 abnormal phrenic nerve innervation pattern to diaphragm 0.253503608693068 0.550013280962937 0.807473728289697 0.545454545454545 7.2 7 2 hypolactation 0.253503608693068 0.550013280962937 0.807473728289697 0.545454545454545 7.2 7 2 impaired swimming 0.0134553655110278 0.0765908963585394 0.807473728289697 0.545454545454545 7.2 7 2 abnormal tooth development 0.0693595587172634 0.233783065459611 0.807473728289697 0.545454545454545 7.2 7 2 abnormal skeleton physiology 0.0693595587172634 0.233783065459611 0.807473728289697 0.545454545454545 7.2 7 2 head tossing 0.0693595587172634 0.233783065459611 0.807473728289697 0.545454545454545 7.2 7 2 decreased sensitivity to xenobiotic induced morbidity/mortality 0.0693595587172634 0.233783065459611 0.807473728289697 0.545454545454545 7.2 7 2 abnormal sleep pattern 0.0377720759394027 0.159385986258294 0.804548098839372 0.543478260869565 7.2 7 2 abnormal liver development 0.0663050706491362 0.224094922880063 0.803628615297841 0.542857142857143 7.2 7 2 impaired behavioral response to xenobiotic 0.0663050706491362 0.224094922880063 0.803628615297841 0.542857142857143 7.2 7 2 abnormal osteoblast morphology 0.120551584018841 0.35741604916194 0.801866271843241 0.541666666666667 7.2 7 2 increased brown adipose tissue amount 0.0633685795087061 0.222206873386174 0.800199190196997 0.540540540540541 7.2 7 2 increased white adipose tissue amount 0.0633685795087061 0.222206873386174 0.800199190196997 0.540540540540541 7.2 7 2 abnormal branching of the mammary ductal tree 0.0633685795087061 0.222206873386174 0.800199190196997 0.540540540540541 7.2 7 2 abnormal cytokine secretion 0.000440338910704994 0.00520352988303408 0.797860945810057 0.538961038961039 7.2 7 2 cachexia 0.00356737540049257 0.0278177000273519 0.797121501003931 0.538461538461538 7.2 7 2 decreased body temperature 0.033286389188116 0.148920671052947 0.797121501003931 0.538461538461538 7.2 7 2 heart inflammation 0.11447653165457 0.339809513712105 0.797121501003931 0.538461538461538 7.2 7 2 increased leukemia incidence 0.11447653165457 0.339809513712105 0.797121501003931 0.538461538461538 7.2 7 2 absent teeth 0.236128587324602 0.518648883858673 0.797121501003931 0.538461538461538 7.2 7 2 absent common myeloid progenitor cells 0.236128587324602 0.518648883858673 0.797121501003931 0.538461538461538 7.2 7 2 short hair 0.236128587324602 0.518648883858673 0.797121501003931 0.538461538461538 7.2 7 2 pup cannibalization 0.236128587324602 0.518648883858673 0.797121501003931 0.538461538461538 7.2 7 2 abnormal pulmonary alveolus epithelial cell morphology 0.236128587324602 0.518648883858673 0.797121501003931 0.538461538461538 7.2 7 2 abnormal bile duct development 0.236128587324602 0.518648883858673 0.797121501003931 0.538461538461538 7.2 7 2 anal atresia 0.236128587324602 0.518648883858673 0.797121501003931 0.538461538461538 7.2 7 2 abnormal dopaminergic neuron morphology 0.236128587324602 0.518648883858673 0.797121501003931 0.538461538461538 7.2 7 2 tracheoesophageal fistula 0.236128587324602 0.518648883858673 0.797121501003931 0.538461538461538 7.2 7 2 decreased alcohol consumption 0.236128587324602 0.518648883858673 0.797121501003931 0.538461538461538 7.2 7 2 abnormal insulin secretion 0.236128587324602 0.518648883858673 0.797121501003931 0.538461538461538 7.2 7 2 muscle fatigue 0.236128587324602 0.518648883858673 0.797121501003931 0.538461538461538 7.2 7 2 abnormal vertebral arch development 0.236128587324602 0.518648883858673 0.797121501003931 0.538461538461538 7.2 7 2 empty decidua capsularis 0.236128587324602 0.518648883858673 0.797121501003931 0.538461538461538 7.2 7 2 abnormal response to injury 0.0605506388044888 0.222206873386174 0.797121501003931 0.538461538461538 7.2 7 2 diluted coat color 0.0318984825165015 0.142968423891527 0.795012713964238 0.537037037037037 7.2 7 2 abnormal long bone epiphyseal plate proliferative zone 0.0318984825165015 0.142968423891527 0.795012713964238 0.537037037037037 7.2 7 2 scaly skin 0.0578502069354161 0.221218124138121 0.794344074171165 0.536585365853659 7.2 7 2 arrested B cell differentiation 0.0578502069354161 0.221218124138121 0.794344074171165 0.536585365853659 7.2 7 2 liver fibrosis 0.0578502069354161 0.221218124138121 0.794344074171165 0.536585365853659 7.2 7 2 decreased IgM level 0.00547102133609706 0.0382279931841052 0.793599609246918 0.536082474226804 7.2 7 2 abnormal ovulation 0.108729382202873 0.323715545457386 0.793054554570238 0.535714285714286 7.2 7 2 abnormal respiration 0.108729382202873 0.323715545457386 0.793054554570238 0.535714285714286 7.2 7 2 abnormal retinal inner nuclear layer morphology 0.108729382202873 0.323715545457386 0.793054554570238 0.535714285714286 7.2 7 2 enhanced coordination 0.108729382202873 0.323715545457386 0.793054554570238 0.535714285714286 7.2 7 2 abnormal male reproductive system morphology 0.0552651397265338 0.218045301253111 0.791825012625168 0.534883720930233 7.2 7 2 cochlear ganglion degeneration 0.0292800725963377 0.133886361366526 0.791231440651686 0.53448275862069 7.2 7 2 liver inflammation 0.00262314894913807 0.0220441993614222 0.789529867661037 0.533333333333333 7.2 7 2 decreased osteoclast cell number 0.0527925420543268 0.209277208542052 0.789529867661037 0.533333333333333 7.2 7 2 abnormal lactation 0.103294933400876 0.308829503407067 0.789529867661037 0.533333333333333 7.2 7 2 absent incisors 0.220598835450206 0.489727445945907 0.789529867661037 0.533333333333333 7.2 7 2 interdigital webbing 0.220598835450206 0.489727445945907 0.789529867661037 0.533333333333333 7.2 7 2 abnormal enteric neuron morphology 0.220598835450206 0.489727445945907 0.789529867661037 0.533333333333333 7.2 7 2 vagina atresia 0.220598835450206 0.489727445945907 0.789529867661037 0.533333333333333 7.2 7 2 hyperpigmentation 0.220598835450206 0.489727445945907 0.789529867661037 0.533333333333333 7.2 7 2 abnormal epidermis stratum spinosum morphology 0.220598835450206 0.489727445945907 0.789529867661037 0.533333333333333 7.2 7 2 abnormal pup retrieval 0.220598835450206 0.489727445945907 0.789529867661037 0.533333333333333 7.2 7 2 audiogenic seizures 0.220598835450206 0.489727445945907 0.789529867661037 0.533333333333333 7.2 7 2 increased airway responsiveness 0.220598835450206 0.489727445945907 0.789529867661037 0.533333333333333 7.2 7 2 increased alcohol consumption 0.220598835450206 0.489727445945907 0.789529867661037 0.533333333333333 7.2 7 2 abnormal coronary vessel morphology 0.220598835450206 0.489727445945907 0.789529867661037 0.533333333333333 7.2 7 2 decreased trabecular bone mass 0.220598835450206 0.489727445945907 0.789529867661037 0.533333333333333 7.2 7 2 abnormal branching involved in lung morphogenesis 0.220598835450206 0.489727445945907 0.789529867661037 0.533333333333333 7.2 7 2 abnormal tooth morphology 0.0257286092550631 0.12144713396162 0.786445766615486 0.53125 7.2 7 2 kidney cortex cysts 0.0981569325211247 0.308003207733853 0.786445766615486 0.53125 7.2 7 2 abnormal epidermis stratum corneum morphology 0.0481708676584503 0.19643448082032 0.785501654050521 0.530612244897959 7.2 7 2 abnormal tail morphology 0.0246395527953764 0.121368094214849 0.785043902503872 0.53030303030303 7.2 7 2 increased monocyte cell number 0.00685673609491764 0.0455394568662128 0.784595305988155 0.53 7.2 7 2 abnormal trabecular bone morphology 0.0035380645284272 0.0276324505948592 0.783724500987059 0.529411764705882 7.2 7 2 increased susceptibility to weight gain 0.093298952957815 0.298113224768869 0.783724500987059 0.529411764705882 7.2 7 2 abnormal skin physiology 0.093298952957815 0.298113224768869 0.783724500987059 0.529411764705882 7.2 7 2 abnormal vagus nerve morphology 0.206584979451455 0.461914729335277 0.783724500987059 0.529411764705882 7.2 7 2 increased aggression towards mice 0.206584979451455 0.461914729335277 0.783724500987059 0.529411764705882 7.2 7 2 abnormal heart rate 0.206584979451455 0.461914729335277 0.783724500987059 0.529411764705882 7.2 7 2 abnormal glutamate-mediated receptor currents 0.206584979451455 0.461914729335277 0.783724500987059 0.529411764705882 7.2 7 2 pancytopenia 0.206584979451455 0.461914729335277 0.783724500987059 0.529411764705882 7.2 7 2 abnormal circulating chemokine level 0.206584979451455 0.461914729335277 0.783724500987059 0.529411764705882 7.2 7 2 increased trabecular bone mass 0.206584979451455 0.461914729335277 0.783724500987059 0.529411764705882 7.2 7 2 abnormal cell cytoskeleton morphology 0.206584979451455 0.461914729335277 0.783724500987059 0.529411764705882 7.2 7 2 short radius 0.0887048955895537 0.287938318174665 0.781305598206234 0.527777777777778 7.2 7 2 abnormal frontal bone morphology 0.0843592674916297 0.281480453233305 0.77914131677076 0.526315789473684 7.2 7 2 abnormal compact bone morphology 0.0843592674916297 0.281480453233305 0.77914131677076 0.526315789473684 7.2 7 2 decreased threshold for auditory brainstem response 0.0843592674916297 0.281480453233305 0.77914131677076 0.526315789473684 7.2 7 2 shiny skin 0.193845434132203 0.435779952466204 0.77914131677076 0.526315789473684 7.2 7 2 decreased grooming behavior 0.193845434132203 0.435779952466204 0.77914131677076 0.526315789473684 7.2 7 2 abnormal long term depression 0.193845434132203 0.435779952466204 0.77914131677076 0.526315789473684 7.2 7 2 abnormal neurotransmitter level 0.193845434132203 0.435779952466204 0.77914131677076 0.526315789473684 7.2 7 2 maternal imprinting 0.193845434132203 0.435779952466204 0.77914131677076 0.526315789473684 7.2 7 2 decreased fertilization frequency 0.193845434132203 0.435779952466204 0.77914131677076 0.526315789473684 7.2 7 2 decreased susceptibility to weight gain 0.193845434132203 0.435779952466204 0.77914131677076 0.526315789473684 7.2 7 2 decreased liver glycogen level 0.193845434132203 0.435779952466204 0.77914131677076 0.526315789473684 7.2 7 2 right-sided stomach 0.193845434132203 0.435779952466204 0.77914131677076 0.526315789473684 7.2 7 2 increased macrophage cell number 0.0401132351251321 0.169121478599604 0.77914131677076 0.526315789473684 7.2 7 2 perinatal lethality 0.080247326886051 0.269023215133493 0.777193463478833 0.525 7.2 7 2 abnormal NK cell physiology 0.0366141951432285 0.158396192032663 0.77658675507643 0.524590163934426 7.2 7 2 increased food intake 0.0166728982401625 0.0904554730041533 0.775431120024233 0.523809523809524 7.2 7 2 small ears 0.182196252994738 0.414963905812287 0.775431120024233 0.523809523809524 7.2 7 2 abnormal hematopoietic system physiology 0.182196252994738 0.414963905812287 0.775431120024233 0.523809523809524 7.2 7 2 abnormal associative learning 0.182196252994738 0.414963905812287 0.775431120024233 0.523809523809524 7.2 7 2 decreased cochlear outer hair cell number 0.182196252994738 0.414963905812287 0.775431120024233 0.523809523809524 7.2 7 2 increased keratinocyte proliferation 0.182196252994738 0.414963905812287 0.775431120024233 0.523809523809524 7.2 7 2 decreased vocalization 0.182196252994738 0.414963905812287 0.775431120024233 0.523809523809524 7.2 7 2 increased circulating creatinine level 0.0159643681815605 0.0877712676049485 0.774611425394186 0.523255813953488 7.2 7 2 decreased sensitivity to induced morbidity/mortality 0.0726696328802636 0.244608540987356 0.773828989610959 0.522727272727273 7.2 7 2 decreased compact bone thickness 0.031943479816791 0.143041235003182 0.773326829332172 0.522388059701492 7.2 7 2 increased bone mineral density 0.00686524475370042 0.0455394568662128 0.772935766460196 0.52212389380531 7.2 7 2 abnormal blood vessel physiology 0.171493194955163 0.414963905812287 0.772366174885797 0.521739130434783 7.2 7 2 abnormal innervation pattern to muscle 0.171493194955163 0.414963905812287 0.772366174885797 0.521739130434783 7.2 7 2 abnormal postnatal growth 0.171493194955163 0.414963905812287 0.772366174885797 0.521739130434783 7.2 7 2 abnormal cochlear ganglion morphology 0.171493194955163 0.414963905812287 0.772366174885797 0.521739130434783 7.2 7 2 increased susceptibility to age related obesity 0.171493194955163 0.414963905812287 0.772366174885797 0.521739130434783 7.2 7 2 abnormal CD4-positive, alpha-beta T cell physiology 0.0291749663689061 0.133528479931286 0.771459641816682 0.52112676056338 7.2 7 2 abnormal cardiovascular system morphology 0.065870272231929 0.222928302281529 0.771025261387731 0.520833333333333 7.2 7 2 abnormal kidney physiology 0.065870272231929 0.222928302281529 0.771025261387731 0.520833333333333 7.2 7 2 abnormal osteoclast morphology 0.065870272231929 0.222928302281529 0.771025261387731 0.520833333333333 7.2 7 2 abnormal circulating protein level 0.0627341902791384 0.222206873386174 0.769791620969511 0.52 7.2 7 2 abnormal energy expenditure 0.161620440269274 0.414963905812287 0.769791620969511 0.52 7.2 7 2 decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 0.161620440269274 0.414963905812287 0.769791620969511 0.52 7.2 7 2 rectal prolapse 0.152483161385606 0.414963905812287 0.76759848244823 0.518518518518518 7.2 7 2 short mandible 0.0542617016582156 0.214588208068063 0.76661940275123 0.517857142857143 7.2 7 2 abnormal parietal bone morphology 0.144002445984657 0.414963905812287 0.765707845791954 0.517241379310345 7.2 7 2 enlarged epididymis 0.144002445984657 0.414963905812287 0.765707845791954 0.517241379310345 7.2 7 2 abnormal kidney development 0.0493067955591066 0.200901972077441 0.764857059296629 0.516666666666667 7.2 7 2 abnormal cranial ganglia morphology 0.13611171731069 0.398326937423932 0.764061162252616 0.516129032258065 7.2 7 2 absent mature ovarian follicles 0.13611171731069 0.398326937423932 0.764061162252616 0.516129032258065 7.2 7 2 abnormal intestine physiology 0.13611171731069 0.398326937423932 0.764061162252616 0.516129032258065 7.2 7 2 abnormal T cell subpopulation ratio 0.128754142187727 0.378576747862851 0.762614076718047 0.515151515151515 7.2 7 2 abnormal intestinal goblet cell morphology 0.121880710696417 0.360926509353972 0.761332372387428 0.514285714285714 7.2 7 2 increased red blood cell distribution width 0.121880710696417 0.360926509353972 0.761332372387428 0.514285714285714 7.2 7 2 abnormal hair follicle development 0.115448784786003 0.34249117728704 0.760189230687147 0.513513513513513 7.2 7 2 abnormal heart looping 0.109420981899146 0.325385167333085 0.759163334289458 0.512820512820513 7.2 7 2 abnormal lens fiber morphology 0.109420981899146 0.325385167333085 0.759163334289458 0.512820512820513 7.2 7 2 short humerus 0.103764302834218 0.310046490450591 0.758237525345203 0.51219512195122 7.2 7 2 abnormal intestinal mucosa morphology 0.0984494409013067 0.308003207733853 0.757397838163204 0.511627906976744 7.2 7 2 short femur 0.0256617732074138 0.12144713396162 0.757006620271591 0.511363636363636 7.2 7 2 altered response to myocardial infarction 0.0934502278346523 0.298404931628623 0.756632789841827 0.511111111111111 7.2 7 2 cleft secondary palate 0.0223806339875074 0.11384100064078 0.755932852015886 0.51063829787234 7.2 7 2 abnormal tibia morphology 0.0887431843716286 0.287938318174665 0.755932852015886 0.51063829787234 7.2 7 2 increased fluid intake 0.0843071519959697 0.281480453233305 0.755290051971655 0.510204081632653 7.2 7 2 abnormal coat/ hair morphology 0.0761733133324632 0.255882669702231 0.754149991515849 0.509433962264151 7.2 7 2 maternal effect 0.0539160648863659 0.213390948933707 0.751231777065539 0.507462686567164 7.2 7 2 abnormal response to infection 0.0404567421326276 0.17042531084659 0.749553671830098 0.506329113924051 7.2 7 2 abnormal hair shaft morphology 0.111616096511328 0.331714504267537 0.740184250932222 0.5 7.2 7 2 hypertension 0.12422924892235 0.367443824844643 0.740184250932222 0.5 7.2 7 2 short maxilla 0.16420933141764 0.414963905812287 0.740184250932222 0.5 7.2 7 2 abnormal bone remodeling 0.16420933141764 0.414963905812287 0.740184250932222 0.5 7.2 7 2 decreased pancreatic beta cell number 0.16420933141764 0.414963905812287 0.740184250932222 0.5 7.2 7 2 decreased regulatory T cell number 0.16420933141764 0.414963905812287 0.740184250932222 0.5 7.2 7 2 abnormal jaw morphology 0.196236940568339 0.440956991566163 0.740184250932222 0.5 7.2 7 2 abnormal foregut morphology 0.222434805891486 0.492265640262518 0.740184250932222 0.5 7.2 7 2 decreased body height 0.222434805891486 0.492265640262518 0.740184250932222 0.5 7.2 7 2 apnea 0.222434805891486 0.492265640262518 0.740184250932222 0.5 7.2 7 2 decreased fatty acid level 0.222434805891486 0.492265640262518 0.740184250932222 0.5 7.2 7 2 hypopigmentation 0.222434805891486 0.492265640262518 0.740184250932222 0.5 7.2 7 2 abnormal basisphenoid bone morphology 0.237425335743241 0.520348478115694 0.740184250932222 0.5 7.2 7 2 abnormal enterocyte morphology 0.237425335743241 0.520348478115694 0.740184250932222 0.5 7.2 7 2 abnormal facial nerve morphology 0.237425335743241 0.520348478115694 0.740184250932222 0.5 7.2 7 2 intestinal inflammation 0.237425335743241 0.520348478115694 0.740184250932222 0.5 7.2 7 2 abnormal retinal layer morphology 0.237425335743241 0.520348478115694 0.740184250932222 0.5 7.2 7 2 abnormal interparietal bone morphology 0.316282907881795 0.619441122214908 0.740184250932222 0.5 7.2 7 2 abnormal vasoconstriction 0.316282907881795 0.619441122214908 0.740184250932222 0.5 7.2 7 2 abnormal zigzag hair morphology 0.316282907881795 0.619441122214908 0.740184250932222 0.5 7.2 7 2 abnormal esophagus morphology 0.343187280633317 0.619441122214908 0.740184250932222 0.5 7.2 7 2 abnormal rectum morphology 0.343187280633317 0.619441122214908 0.740184250932222 0.5 7.2 7 2 amyloidosis 0.343187280633317 0.619441122214908 0.740184250932222 0.5 7.2 7 2 abnormal pilomotor reflex 0.343187280633317 0.619441122214908 0.740184250932222 0.5 7.2 7 2 absent visceral yolk sac blood islands 0.316282907881795 0.619441122214908 0.740184250932222 0.5 7.2 7 2 increased urine phosphate level 0.343187280633317 0.619441122214908 0.740184250932222 0.5 7.2 7 2 increased circulating parathyroid hormone level 0.343187280633317 0.619441122214908 0.740184250932222 0.5 7.2 7 2 absent otoliths 0.316282907881795 0.619441122214908 0.740184250932222 0.5 7.2 7 2 abnormal alisphenoid bone morphology 0.343187280633317 0.619441122214908 0.740184250932222 0.5 7.2 7 2 increased fear-related response 0.343187280633317 0.619441122214908 0.740184250932222 0.5 7.2 7 2 delayed somite formation 0.343187280633317 0.619441122214908 0.740184250932222 0.5 7.2 7 2 skeletal muscle necrosis 0.316282907881795 0.619441122214908 0.740184250932222 0.5 7.2 7 2 vestibular saccular macula degeneration 0.343187280633317 0.619441122214908 0.740184250932222 0.5 7.2 7 2 small parietal bone 0.343187280633317 0.619441122214908 0.740184250932222 0.5 7.2 7 2 abnormal cochlear outer hair cell physiology 0.343187280633317 0.619441122214908 0.740184250932222 0.5 7.2 7 2 abnormal positive T cell selection 0.316282907881795 0.619441122214908 0.740184250932222 0.5 7.2 7 2 abnormal palatine bone morphology 0.343187280633317 0.619441122214908 0.740184250932222 0.5 7.2 7 2 abnormal patella morphology 0.343187280633317 0.619441122214908 0.740184250932222 0.5 7.2 7 2 hydrometra 0.343187280633317 0.619441122214908 0.740184250932222 0.5 7.2 7 2 decreased prostaglandin level 0.343187280633317 0.619441122214908 0.740184250932222 0.5 7.2 7 2 abnormal aorta elastic tissue morphology 0.343187280633317 0.619441122214908 0.740184250932222 0.5 7.2 7 2 abnormal respiratory motile cilium morphology 0.343187280633317 0.619441122214908 0.740184250932222 0.5 7.2 7 2 thick epidermis 0.0638148419837569 0.222206873386174 0.740184250932222 0.5 7.2 7 2 dehydration 0.0638148419837569 0.222206873386174 0.740184250932222 0.5 7.2 7 2 decreased eosinophil cell number 0.0740298038711039 0.249018441013348 0.740184250932222 0.5 7.2 7 2 abnormal digestive system physiology 0.105880113712801 0.316178610877062 0.740184250932222 0.5 7.2 7 2 abnormal female reproductive system morphology 0.138594636912242 0.405116520939131 0.740184250932222 0.5 7.2 7 2 abnormal skin pigmentation 0.138594636912242 0.405116520939131 0.740184250932222 0.5 7.2 7 2 abnormal epidermis stratum granulosum morphology 0.15505652580328 0.414963905812287 0.740184250932222 0.5 7.2 7 2 abnormal lymphatic vessel morphology 0.174066502100255 0.414963905812287 0.740184250932222 0.5 7.2 7 2 increased dopamine level 0.174066502100255 0.414963905812287 0.740184250932222 0.5 7.2 7 2 abnormal lumbar vertebrae morphology 0.174066502100255 0.414963905812287 0.740184250932222 0.5 7.2 7 2 abnormal retinal outer nuclear layer morphology 0.146538302080377 0.414963905812287 0.740184250932222 0.5 7.2 7 2 abnormal incus morphology 0.253960173444928 0.55028391240789 0.740184250932222 0.5 7.2 7 2 nuclear cataracts 0.253960173444928 0.55028391240789 0.740184250932222 0.5 7.2 7 2 delayed kidney development 0.272330340729169 0.584831219733652 0.740184250932222 0.5 7.2 7 2 thick dermal layer 0.272330340729169 0.584831219733652 0.740184250932222 0.5 7.2 7 2 absent allantois 0.272330340729169 0.584831219733652 0.740184250932222 0.5 7.2 7 2 abnormal sperm axoneme morphology 0.272330340729169 0.584831219733652 0.740184250932222 0.5 7.2 7 2 abnormal metanephric mesenchyme morphology 0.272330340729169 0.584831219733652 0.740184250932222 0.5 7.2 7 2 abnormal tympanic ring morphology 0.292924836851373 0.61625544680827 0.740184250932222 0.5 7.2 7 2 abnormal bone marrow cell number 0.292924836851373 0.61625544680827 0.740184250932222 0.5 7.2 7 2 reduced male mating frequency 0.292924836851373 0.61625544680827 0.740184250932222 0.5 7.2 7 2 abnormal extraembryonic endoderm formation 0.292924836851373 0.61625544680827 0.740184250932222 0.5 7.2 7 2 white spotting 0.292924836851373 0.61625544680827 0.740184250932222 0.5 7.2 7 2 paternal imprinting 0.292924836851373 0.61625544680827 0.740184250932222 0.5 7.2 7 2 abnormal pulmonary elastic fiber morphology 0.292924836851373 0.61625544680827 0.740184250932222 0.5 7.2 7 2 large intestinal inflammation 0.292924836851373 0.61625544680827 0.740184250932222 0.5 7.2 7 2 small pancreas 0.292924836851373 0.61625544680827 0.740184250932222 0.5 7.2 7 2 bowed tibia 0.292924836851373 0.61625544680827 0.740184250932222 0.5 7.2 7 2 small epididymis 0.292924836851373 0.61625544680827 0.740184250932222 0.5 7.2 7 2 decreased creatinine clearance 0.292924836851373 0.61625544680827 0.740184250932222 0.5 7.2 7 2 abnormal lateral semicircular canal morphology 0.374844199941657 0.619441122214908 0.740184250932222 0.5 7.2 7 2 kidney hemorrhage 0.374844199941657 0.619441122214908 0.740184250932222 0.5 7.2 7 2 jaundice 0.374844199941657 0.619441122214908 0.740184250932222 0.5 7.2 7 2 abnormal optic nerve innervation 0.374844199941657 0.619441122214908 0.740184250932222 0.5 7.2 7 2 abnormal mammary gland physiology 0.374844199941657 0.619441122214908 0.740184250932222 0.5 7.2 7 2 primary sex reversal 0.374844199941657 0.619441122214908 0.740184250932222 0.5 7.2 7 2 delayed dark adaptation 0.374844199941657 0.619441122214908 0.740184250932222 0.5 7.2 7 2 absent seminal vesicle 0.374844199941657 0.619441122214908 0.740184250932222 0.5 7.2 7 2 abnormal glial cell physiology 0.374844199941657 0.619441122214908 0.740184250932222 0.5 7.2 7 2 absent CD4-positive, alpha beta T cells 0.374844199941657 0.619441122214908 0.740184250932222 0.5 7.2 7 2 abnormal pillar cell morphology 0.374844199941657 0.619441122214908 0.740184250932222 0.5 7.2 7 2 abnormal hindlimb zeugopod morphology 0.374844199941657 0.619441122214908 0.740184250932222 0.5 7.2 7 2 absent pharyngeal arches 0.374844199941657 0.619441122214908 0.740184250932222 0.5 7.2 7 2 abnormal placental transport 0.374844199941657 0.619441122214908 0.740184250932222 0.5 7.2 7 2 abnormal utricular macula morphology 0.374844199941657 0.619441122214908 0.740184250932222 0.5 7.2 7 2 decreased cochlear inner hair cell number 0.374844199941657 0.619441122214908 0.740184250932222 0.5 7.2 7 2 decreased thyroxine level 0.374844199941657 0.619441122214908 0.740184250932222 0.5 7.2 7 2 acanthocytosis 0.374844199941657 0.619441122214908 0.740184250932222 0.5 7.2 7 2 increased T-helper 17 cell number 0.374844199941657 0.619441122214908 0.740184250932222 0.5 7.2 7 2 abnormal vibrissa follicle morphology 0.374844199941657 0.619441122214908 0.740184250932222 0.5 7.2 7 2 thick aortic valve 0.374844199941657 0.619441122214908 0.740184250932222 0.5 7.2 7 2 abnormal pulmonary interalveolar septum morphology 0.374844199941657 0.619441122214908 0.740184250932222 0.5 7.2 7 2 abnormal humoral immune response 0.0347298684308451 0.152768430984487 0.73313487711382 0.495238095238095 7.2 7 2 abnormal epidermal layer morphology 0.0822513041230836 0.275370281300364 0.729456942947697 0.492753623188406 7.2 7 2 lung inflammation 0.0211544027054024 0.109514207553982 0.729299188418513 0.492647058823529 7.2 7 2 abnormal colon morphology 0.105957531280327 0.3162199868744 0.72763875515371 0.491525423728814 7.2 7 2 abnormal thrombosis 0.130646580383276 0.38391419811388 0.725670834247277 0.490196078431373 7.2 7 2 abnormal T-helper 1 physiology 0.145493268197364 0.414963905812287 0.724435649848558 0.48936170212766 7.2 7 2 kidney failure 0.162410020541096 0.414963905812287 0.72297066370124 0.488372093023256 7.2 7 2 increased tumor growth/size 0.171766383653216 0.414963905812287 0.722130976519241 0.48780487804878 7.2 7 2 increased vascular permeability 0.181799756252546 0.414963905812287 0.721205167574986 0.487179487179487 7.2 7 2 abnormal leukocyte adhesion 0.181799756252546 0.414963905812287 0.721205167574986 0.487179487179487 7.2 7 2 abnormal long bone metaphysis morphology 0.192579648872279 0.434702247341011 0.720179271177297 0.486486486486487 7.2 7 2 increased trabecular bone volume 0.192579648872279 0.434702247341011 0.720179271177297 0.486486486486487 7.2 7 2 decreased bone mineralization 0.204186362098795 0.458198985765226 0.719036129477016 0.485714285714286 7.2 7 2 deafness 0.060648250976111 0.222206873386174 0.717754425146397 0.484848484848485 7.2 7 2 decreased systemic arterial blood pressure 0.216713429076752 0.483909025878294 0.717754425146397 0.484848484848485 7.2 7 2 autoimmune response 0.230270809747576 0.509154345997417 0.716307339611828 0.483870967741935 7.2 7 2 abnormal eye physiology 0.128507508976211 0.37807501901635 0.715511442567815 0.483333333333333 7.2 7 2 increased double-positive T cell number 0.244989135513109 0.536452882560615 0.71466065607249 0.482758620689655 7.2 7 2 cryptorchism 0.261025451561038 0.565100792652814 0.712770019416214 0.481481481481481 7.2 7 2 decreased bone ossification 0.261025451561038 0.565100792652814 0.712770019416214 0.481481481481481 7.2 7 2 decreased IgA level 0.158573268250842 0.414963905812287 0.711715625896367 0.480769230769231 7.2 7 2 abnormal leukocyte migration 0.158573268250842 0.414963905812287 0.711715625896367 0.480769230769231 7.2 7 2 abnormal hindlimb morphology 0.167327362815246 0.414963905812287 0.710576880894933 0.48 7.2 7 2 kidney inflammation 0.167327362815246 0.414963905812287 0.710576880894933 0.48 7.2 7 2 increased pre-B cell number 0.278571143388911 0.595058582378632 0.710576880894933 0.48 7.2 7 2 abnormal feces composition 0.278571143388911 0.595058582378632 0.710576880894933 0.48 7.2 7 2 diaphragmatic hernia 0.278571143388911 0.595058582378632 0.710576880894933 0.48 7.2 7 2 abnormal cochlear outer hair cell morphology 0.278571143388911 0.595058582378632 0.710576880894933 0.48 7.2 7 2 abnormal vertebrae development 0.278571143388911 0.595058582378632 0.710576880894933 0.48 7.2 7 2 hyperkeratosis 0.125456413562143 0.37085303474252 0.708002326978647 0.478260869565217 7.2 7 2 delayed wound healing 0.18662247772981 0.421637977613899 0.708002326978647 0.478260869565217 7.2 7 2 bidirectional circling 0.297863131465647 0.619251600100958 0.708002326978647 0.478260869565217 7.2 7 2 abnormal cardiovascular development 0.297863131465647 0.619251600100958 0.708002326978647 0.478260869565217 7.2 7 2 abnormal gametogenesis 0.197270725062559 0.443079845230805 0.706539512253485 0.477272727272727 7.2 7 2 increased incidence of induced tumors 0.319200101126918 0.619441122214908 0.704937381840211 0.476190476190476 7.2 7 2 abnormal clavicle morphology 0.319200101126918 0.619441122214908 0.704937381840211 0.476190476190476 7.2 7 2 increased bone ossification 0.319200101126918 0.619441122214908 0.704937381840211 0.476190476190476 7.2 7 2 impaired ovarian folliculogenesis 0.220890102322345 0.489936807424729 0.703175038385611 0.475 7.2 7 2 head bobbing 0.220890102322345 0.489936807424729 0.703175038385611 0.475 7.2 7 2 short vibrissae 0.342966756666439 0.619441122214908 0.701227185093684 0.473684210526316 7.2 7 2 decreased germ cell number 0.342966756666439 0.619441122214908 0.701227185093684 0.473684210526316 7.2 7 2 osteoarthritis 0.342966756666439 0.619441122214908 0.701227185093684 0.473684210526316 7.2 7 2 increased left ventricle weight 0.342966756666439 0.619441122214908 0.701227185093684 0.473684210526316 7.2 7 2 abnormal T-helper 2 physiology 0.179759738019666 0.414963905812287 0.699810564517737 0.472727272727273 7.2 7 2 increased susceptibility to bacterial infection induced morbidity/mortality 0.141266803400348 0.410515389554164 0.69906290365821 0.472222222222222 7.2 7 2 circling 0.123807435073785 0.366414033011352 0.696644000877385 0.470588235294118 7.2 7 2 abnormal retinal photoreceptor morphology 0.263383738107073 0.569462884434024 0.696644000877385 0.470588235294118 7.2 7 2 hydroureter 0.36967137676241 0.619441122214908 0.696644000877385 0.470588235294118 7.2 7 2 distended urinary bladder 0.36967137676241 0.619441122214908 0.696644000877385 0.470588235294118 7.2 7 2 enlarged sebaceous gland 0.36967137676241 0.619441122214908 0.696644000877385 0.470588235294118 7.2 7 2 aminoaciduria 0.36967137676241 0.619441122214908 0.696644000877385 0.470588235294118 7.2 7 2 abnormal melanosome morphology 0.36967137676241 0.619441122214908 0.696644000877385 0.470588235294118 7.2 7 2 common atrium 0.36967137676241 0.619441122214908 0.696644000877385 0.470588235294118 7.2 7 2 organ of Corti degeneration 0.211007743331451 0.471591879188665 0.694866847813923 0.469387755102041 7.2 7 2 abnormal crypts of Lieberkuhn morphology 0.279862845906976 0.597561226775625 0.693922735248958 0.46875 7.2 7 2 increased systemic arterial blood pressure 0.222816182118362 0.492890398416564 0.692938447681229 0.468085106382979 7.2 7 2 increased eosinophil cell number 0.181601162932915 0.414963905812287 0.692430428291433 0.467741935483871 7.2 7 2 arrested T cell differentiation 0.297733415339696 0.619251600100958 0.690838634203407 0.466666666666667 7.2 7 2 emphysema 0.297733415339696 0.619251600100958 0.690838634203407 0.466666666666667 7.2 7 2 abnormal fontanelle morphology 0.400006471259434 0.619441122214908 0.690838634203407 0.466666666666667 7.2 7 2 no suckling reflex 0.400006471259434 0.619441122214908 0.690838634203407 0.466666666666667 7.2 7 2 abnormal respiratory system morphology 0.400006471259434 0.619441122214908 0.690838634203407 0.466666666666667 7.2 7 2 dilated ureter 0.400006471259434 0.619441122214908 0.690838634203407 0.466666666666667 7.2 7 2 greasy coat 0.400006471259434 0.619441122214908 0.690838634203407 0.466666666666667 7.2 7 2 abnormal zygomatic bone morphology 0.400006471259434 0.619441122214908 0.690838634203407 0.466666666666667 7.2 7 2 abnormal Muller cell morphology 0.400006471259434 0.619441122214908 0.690838634203407 0.466666666666667 7.2 7 2 liver vascular congestion 0.400006471259434 0.619441122214908 0.690838634203407 0.466666666666667 7.2 7 2 ostium primum atrial septal defect 0.400006471259434 0.619441122214908 0.690838634203407 0.466666666666667 7.2 7 2 reddish skin 0.317175494421378 0.619441122214908 0.687313947294206 0.464285714285714 7.2 7 2 increased circulating luteinizing hormone level 0.317175494421378 0.619441122214908 0.687313947294206 0.464285714285714 7.2 7 2 decreased monocyte cell number 0.201581650540456 0.452558082779227 0.683247000860513 0.461538461538462 7.2 7 2 abnormal hair growth 0.235383275186717 0.518648883858673 0.683247000860513 0.461538461538462 7.2 7 2 abnormal leukocyte cell number 0.338405538678854 0.619441122214908 0.683247000860513 0.461538461538462 7.2 7 2 small seminal vesicle 0.338405538678854 0.619441122214908 0.683247000860513 0.461538461538462 7.2 7 2 absent myocardial trabeculae 0.434951874897928 0.655325735196 0.683247000860513 0.461538461538462 7.2 7 2 abnormal mast cell morphology 0.434951874897928 0.655325735196 0.683247000860513 0.461538461538462 7.2 7 2 small trigeminal ganglion 0.434951874897928 0.655325735196 0.683247000860513 0.461538461538462 7.2 7 2 tight skin 0.434951874897928 0.655325735196 0.683247000860513 0.461538461538462 7.2 7 2 abnormal digestion 0.434951874897928 0.655325735196 0.683247000860513 0.461538461538462 7.2 7 2 absent lateral semicircular canal 0.434951874897928 0.655325735196 0.683247000860513 0.461538461538462 7.2 7 2 abnormal vestibulocochlear ganglion morphology 0.434951874897928 0.655325735196 0.683247000860513 0.461538461538462 7.2 7 2 small interparietal bone 0.434951874897928 0.655325735196 0.683247000860513 0.461538461538462 7.2 7 2 increased circulating ammonia level 0.434951874897928 0.655325735196 0.683247000860513 0.461538461538462 7.2 7 2 increased renin activity 0.434951874897928 0.655325735196 0.683247000860513 0.461538461538462 7.2 7 2 abnormal hair follicle inner root sheath morphology 0.434951874897928 0.655325735196 0.683247000860513 0.461538461538462 7.2 7 2 increased insulin secretion 0.2953748763147 0.61625544680827 0.680169311667447 0.459459459459459 7.2 7 2 skin inflammation 0.2953748763147 0.61625544680827 0.680169311667447 0.459459459459459 7.2 7 2 abnormal intestinal epithelium morphology 0.261871187939 0.566685150063734 0.678502230021204 0.458333333333333 7.2 7 2 increased circulating total protein level 0.361687099259167 0.619441122214908 0.678502230021204 0.458333333333333 7.2 7 2 increased sensitivity to induced morbidity/mortality 0.0807347772511976 0.270475095504854 0.675820403025072 0.456521739130435 7.2 7 2 impaired natural killer cell mediated cytotoxicity 0.246646798357325 0.53984506019696 0.675255807867992 0.456140350877193 7.2 7 2 abnormal photoreceptor outer segment morphology 0.291913908907997 0.61625544680827 0.672894773574747 0.454545454545455 7.2 7 2 cochlear hair cell degeneration 0.291913908907997 0.61625544680827 0.672894773574747 0.454545454545455 7.2 7 2 abnormal tracheal cartilage morphology 0.387345738946649 0.619441122214908 0.672894773574747 0.454545454545455 7.2 7 2 abnormal female reproductive system physiology 0.387345738946649 0.619441122214908 0.672894773574747 0.454545454545455 7.2 7 2 abnormal temporal bone morphology 0.387345738946649 0.619441122214908 0.672894773574747 0.454545454545455 7.2 7 2 failure of palatal shelf elevation 0.387345738946649 0.619441122214908 0.672894773574747 0.454545454545455 7.2 7 2 absent semicircular canals 0.475961359315481 0.699116552286542 0.672894773574747 0.454545454545455 7.2 7 2 abnormal awl hair morphology 0.475961359315481 0.699116552286542 0.672894773574747 0.454545454545455 7.2 7 2 enlarged cranium 0.475961359315481 0.699116552286542 0.672894773574747 0.454545454545455 7.2 7 2 abnormal enteric ganglia morphology 0.475961359315481 0.699116552286542 0.672894773574747 0.454545454545455 7.2 7 2 secondary sex reversal 0.475961359315481 0.699116552286542 0.672894773574747 0.454545454545455 7.2 7 2 abnormal primary sex determination 0.475961359315481 0.699116552286542 0.672894773574747 0.454545454545455 7.2 7 2 patent ductus arteriosus 0.475961359315481 0.699116552286542 0.672894773574747 0.454545454545455 7.2 7 2 abnormal frequency of paradoxical sleep 0.475961359315481 0.699116552286542 0.672894773574747 0.454545454545455 7.2 7 2 abnormal nerve fiber response 0.475961359315481 0.699116552286542 0.672894773574747 0.454545454545455 7.2 7 2 pulmonary hypertension 0.475961359315481 0.699116552286542 0.672894773574747 0.454545454545455 7.2 7 2 pathological neovascularization 0.475961359315481 0.699116552286542 0.672894773574747 0.454545454545455 7.2 7 2 abnormal hair medulla 0.475961359315481 0.699116552286542 0.672894773574747 0.454545454545455 7.2 7 2 abnormal crista ampullaris neuroepithelium morphology 0.475961359315481 0.699116552286542 0.672894773574747 0.454545454545455 7.2 7 2 increased circulating triiodothyronine level 0.475961359315481 0.699116552286542 0.672894773574747 0.454545454545455 7.2 7 2 abnormal superovulation 0.475961359315481 0.699116552286542 0.672894773574747 0.454545454545455 7.2 7 2 enhanced behavioral response to addictive substance 0.475961359315481 0.699116552286542 0.672894773574747 0.454545454545455 7.2 7 2 abnormal aorta smooth muscle morphology 0.475961359315481 0.699116552286542 0.672894773574747 0.454545454545455 7.2 7 2 aberrant origin of the right subclavian artery 0.475961359315481 0.699116552286542 0.672894773574747 0.454545454545455 7.2 7 2 increased subcutaneous adipose tissue amount 0.475961359315481 0.699116552286542 0.672894773574747 0.454545454545455 7.2 7 2 chylous ascites 0.475961359315481 0.699116552286542 0.672894773574747 0.454545454545455 7.2 7 2 dextrocardia 0.332487359932163 0.619441122214908 0.672894773574747 0.454545454545455 7.2 7 2 absent vibrissae 0.332487359932163 0.619441122214908 0.672894773574747 0.454545454545455 7.2 7 2 abnormal vibrissa morphology 0.308457553512429 0.619441122214908 0.669690512748201 0.452380952380952 7.2 7 2 abnormal CD8-positive, alpha beta T cell morphology 0.35329085523909 0.619441122214908 0.668553516971039 0.451612903225806 7.2 7 2 abnormal basioccipital bone morphology 0.415790324756766 0.628740688651949 0.666165825839 0.45 7.2 7 2 waved hair 0.415790324756766 0.628740688651949 0.666165825839 0.45 7.2 7 2 decreased skin tensile strength 0.415790324756766 0.628740688651949 0.666165825839 0.45 7.2 7 2 abnormal food intake 0.253718542469975 0.55023964637669 0.665093095040547 0.449275362318841 7.2 7 2 decreased urine osmolality 0.303315476137744 0.619441122214908 0.664655245735056 0.448979591836735 7.2 7 2 abnormal circulating glucose level 0.375826911034346 0.619441122214908 0.663613466353027 0.448275862068966 7.2 7 2 focal hair loss 0.375826911034346 0.619441122214908 0.663613466353027 0.448275862068966 7.2 7 2 abnormal urine homeostasis 0.213821835986853 0.477666652013738 0.663081724793449 0.447916666666667 7.2 7 2 abnormal femur morphology 0.266074697204852 0.575031111465743 0.662851567999005 0.447761194029851 7.2 7 2 abnormal T cell activation 0.262191831045367 0.567132330195958 0.660164331912522 0.445945945945946 7.2 7 2 abnormal systemic arterial blood pressure 0.365305778672612 0.619441122214908 0.657941556384197 0.444444444444444 7.2 7 2 impaired wound healing 0.365305778672612 0.619441122214908 0.657941556384197 0.444444444444444 7.2 7 2 head tilt 0.365305778672612 0.619441122214908 0.657941556384197 0.444444444444444 7.2 7 2 abnormal heart shape 0.447544205589003 0.673075097583219 0.657941556384197 0.444444444444444 7.2 7 2 abnormal radius morphology 0.447544205589003 0.673075097583219 0.657941556384197 0.444444444444444 7.2 7 2 abnormal iron level 0.447544205589003 0.673075097583219 0.657941556384197 0.444444444444444 7.2 7 2 increased susceptibility to parasitic infection 0.243497623476849 0.533421698281517 0.657941556384197 0.444444444444444 7.2 7 2 abnormal heart valve morphology 0.400309608373107 0.619441122214908 0.657941556384197 0.444444444444444 7.2 7 2 abnormal single cell response 0.400309608373107 0.619441122214908 0.657941556384197 0.444444444444444 7.2 7 2 increased percent body fat/body weight 0.329513874090852 0.619441122214908 0.654778375824658 0.442307692307692 7.2 7 2 decreased cytotoxic T cell cytolysis 0.387042850846707 0.619441122214908 0.653103750822549 0.441176470588235 7.2 7 2 abnormal stomach mucosa morphology 0.426992493157225 0.645483942101852 0.651362140820355 0.44 7.2 7 2 short ulna 0.375297024264902 0.619441122214908 0.649917878867317 0.439024390243902 7.2 7 2 abnormal diaphragm morphology 0.410401529164067 0.625499053346265 0.647661219565694 0.4375 7.2 7 2 decreased mast cell number 0.483292186910148 0.708629127579719 0.647661219565694 0.4375 7.2 7 2 abnormal molar crown morphology 0.483292186910148 0.708629127579719 0.647661219565694 0.4375 7.2 7 2 bowed radius 0.483292186910148 0.708629127579719 0.647661219565694 0.4375 7.2 7 2 abnormal amnion morphology 0.483292186910148 0.708629127579719 0.647661219565694 0.4375 7.2 7 2 decreased circulating prolactin level 0.483292186910148 0.708629127579719 0.647661219565694 0.4375 7.2 7 2 decreased skeletal muscle weight 0.483292186910148 0.708629127579719 0.647661219565694 0.4375 7.2 7 2 abnormal ulna morphology 0.456178513932036 0.683814809564768 0.643638479071497 0.434782608695652 7.2 7 2 salivary gland inflammation 0.435545466565549 0.655822849928452 0.641493017474592 0.433333333333333 7.2 7 2 abnormal pain threshold 0.435545466565549 0.655822849928452 0.641493017474592 0.433333333333333 7.2 7 2 decreased macrophage cell number 0.404022217996081 0.620565154223681 0.63925003489601 0.431818181818182 7.2 7 2 abnormal inflammatory response 0.359247266292138 0.619441122214908 0.637380882747191 0.430555555555556 7.2 7 2 decreased inflammatory response 0.35575436687909 0.619441122214908 0.63444364365619 0.428571428571429 7.2 7 2 abnormal spleen germinal center morphology 0.462660193836904 0.684225465023365 0.63444364365619 0.428571428571429 7.2 7 2 dry skin 0.488232992479152 0.715241206591219 0.63444364365619 0.428571428571429 7.2 7 2 abnormal bile salt homeostasis 0.488232992479152 0.715241206591219 0.63444364365619 0.428571428571429 7.2 7 2 vascular ring 0.488232992479152 0.715241206591219 0.63444364365619 0.428571428571429 7.2 7 2 absent atrioventricular cushions 0.523953600160029 0.74354190543841 0.63444364365619 0.428571428571429 7.2 7 2 abnormal antigen presentation 0.523953600160029 0.74354190543841 0.63444364365619 0.428571428571429 7.2 7 2 decreased coping response 0.523953600160029 0.74354190543841 0.63444364365619 0.428571428571429 7.2 7 2 abnormal pancreas development 0.523953600160029 0.74354190543841 0.63444364365619 0.428571428571429 7.2 7 2 abnormal iris pigmentation 0.523953600160029 0.74354190543841 0.63444364365619 0.428571428571429 7.2 7 2 abnormal glucose tolerance 0.523953600160029 0.74354190543841 0.63444364365619 0.428571428571429 7.2 7 2 decreased cornea thickness 0.523953600160029 0.74354190543841 0.63444364365619 0.428571428571429 7.2 7 2 sternebra fusion 0.523953600160029 0.74354190543841 0.63444364365619 0.428571428571429 7.2 7 2 increased lung compliance 0.523953600160029 0.74354190543841 0.63444364365619 0.428571428571429 7.2 7 2 ovary cysts 0.442399368975153 0.665941561467892 0.63444364365619 0.428571428571429 7.2 7 2 diarrhea 0.467811969650733 0.691638796140386 0.628035122003097 0.424242424242424 7.2 7 2 abnormal kidney cortex morphology 0.491956259774697 0.720483483184903 0.626309750788803 0.423076923076923 7.2 7 2 irregular coat pigmentation 0.52360053207814 0.74354190543841 0.623313053416608 0.421052631578947 7.2 7 2 abnormal photoreceptor inner segment morphology 0.52360053207814 0.74354190543841 0.623313053416608 0.421052631578947 7.2 7 2 abnormal cochlear inner hair cell morphology 0.52360053207814 0.74354190543841 0.623313053416608 0.421052631578947 7.2 7 2 abnormal T cell proliferation 0.494951574745769 0.724656881801118 0.620799694330251 0.419354838709677 7.2 7 2 abnormal organ of Corti morphology 0.475693294511074 0.699116552286542 0.619689140315349 0.418604651162791 7.2 7 2 impaired macrophage phagocytosis 0.475693294511074 0.699116552286542 0.619689140315349 0.418604651162791 7.2 7 2 curly vibrissae 0.523672381555513 0.74354190543841 0.616820209110185 0.416666666666667 7.2 7 2 decreased ovulation rate 0.523672381555513 0.74354190543841 0.616820209110185 0.416666666666667 7.2 7 2 abnormal cellular extravasation 0.523672381555513 0.74354190543841 0.616820209110185 0.416666666666667 7.2 7 2 small thyroid gland 0.570799986945599 0.796334810727525 0.616820209110185 0.416666666666667 7.2 7 2 decreased circulating ketone body level 0.570799986945599 0.796334810727525 0.616820209110185 0.416666666666667 7.2 7 2 impaired sperm capacitation 0.570799986945599 0.796334810727525 0.616820209110185 0.416666666666667 7.2 7 2 bowed ulna 0.570799986945599 0.796334810727525 0.616820209110185 0.416666666666667 7.2 7 2 decreased cochlear nerve compound action potential 0.570799986945599 0.796334810727525 0.616820209110185 0.416666666666667 7.2 7 2 abnormal B cell proliferation 0.570799986945599 0.796334810727525 0.616820209110185 0.416666666666667 7.2 7 2 decreased renal glomerular filtration rate 0.570799986945599 0.796334810727525 0.616820209110185 0.416666666666667 7.2 7 2 increased type II pneumocyte number 0.570799986945599 0.796334810727525 0.616820209110185 0.416666666666667 7.2 7 2 abnormal middle ear morphology 0.523954275815181 0.74354190543841 0.612566276633563 0.413793103448276 7.2 7 2 abnormal inner ear morphology 0.501563991666398 0.73412205311572 0.611456555117923 0.41304347826087 7.2 7 2 increased width of hypertrophic chondrocyte zone 0.524350352813552 0.74354190543841 0.609563500767712 0.411764705882353 7.2 7 2 abnormal urinary bladder morphology 0.562826754013564 0.786976700735661 0.609563500767712 0.411764705882353 7.2 7 2 delayed heart development 0.562826754013564 0.786976700735661 0.609563500767712 0.411764705882353 7.2 7 2 intestinal ulcer 0.558078014155501 0.78077562441609 0.605605296217273 0.409090909090909 7.2 7 2 decreased cardiac output 0.558078014155501 0.78077562441609 0.605605296217273 0.409090909090909 7.2 7 2 decreased susceptibility to viral infection induced morbidity/mortality 0.558078014155501 0.78077562441609 0.605605296217273 0.409090909090909 7.2 7 2 impaired humoral immune response 0.558078014155501 0.78077562441609 0.605605296217273 0.409090909090909 7.2 7 2 wrinkled skin 0.55496333261329 0.77729239294795 0.603113093352181 0.407407407407407 7.2 7 2 decreased susceptibility to parasitic infection 0.552801605933248 0.774482677983078 0.60139970388243 0.40625 7.2 7 2 abnormal immune system physiology 0.533641260286433 0.748060092962807 0.596922783009856 0.403225806451613 7.2 7 2 abnormal response/metabolism to endogenous compounds 0.54729595425638 0.766985175331124 0.595758055628374 0.402439024390244 7.2 7 2 increased susceptibility to weight loss 0.575963866642092 0.803313775313823 0.592147400745778 0.4 7.2 7 2 abnormal estrous cycle 0.582893481981603 0.811404671067612 0.592147400745778 0.4 7.2 7 2 decreased acute inflammation 0.588125640487705 0.812756961507315 0.592147400745778 0.4 7.2 7 2 decreased chondrocyte number 0.606585019427093 0.824423642001984 0.592147400745778 0.4 7.2 7 2 decreased salivation 0.606585019427093 0.824423642001984 0.592147400745778 0.4 7.2 7 2 abnormal pericyte morphology 0.606585019427093 0.824423642001984 0.592147400745778 0.4 7.2 7 2 abnormal ear development 0.606585019427093 0.824423642001984 0.592147400745778 0.4 7.2 7 2 abnormal rostral migratory stream morphology 0.606585019427093 0.824423642001984 0.592147400745778 0.4 7.2 7 2 lactation failure 0.606585019427093 0.824423642001984 0.592147400745778 0.4 7.2 7 2 abnormal middle ear ossicle morphology 0.608044869516883 0.824423642001984 0.583175470431448 0.393939393939394 7.2 7 2 abnormal stria vascularis morphology 0.61468889299801 0.824423642001984 0.581573340018174 0.392857142857143 7.2 7 2 abnormal immune system morphology 0.619863135659991 0.824423642001984 0.579274631164348 0.391304347826087 7.2 7 2 abnormal chondrocyte physiology 0.623584835727728 0.824423642001984 0.579274631164348 0.391304347826087 7.2 7 2 abnormal retinal rod cell morphology 0.636188375738285 0.824423642001984 0.575698861836173 0.388888888888889 7.2 7 2 abnormal macrophage chemotaxis 0.636188375738285 0.824423642001984 0.575698861836173 0.388888888888889 7.2 7 2 impaired leukocyte tethering or rolling 0.636188375738285 0.824423642001984 0.575698861836173 0.388888888888889 7.2 7 2 pulmonary edema 0.648231503433336 0.829889791451582 0.569372500717094 0.384615384615385 7.2 7 2 absent trabeculae carneae 0.655705056975393 0.837518012439687 0.569372500717094 0.384615384615385 7.2 7 2 abnormal sympathetic ganglion morphology 0.655705056975393 0.837518012439687 0.569372500717094 0.384615384615385 7.2 7 2 uterus hypoplasia 0.655705056975393 0.837518012439687 0.569372500717094 0.384615384615385 7.2 7 2 increased circulating adrenocorticotropin level 0.655705056975393 0.837518012439687 0.569372500717094 0.384615384615385 7.2 7 2 abnormal intercostal muscle morphology 0.655705056975393 0.837518012439687 0.569372500717094 0.384615384615385 7.2 7 2 abnormal otolith morphology 0.655705056975393 0.837518012439687 0.569372500717094 0.384615384615385 7.2 7 2 decreased endocochlear potential 0.655705056975393 0.837518012439687 0.569372500717094 0.384615384615385 7.2 7 2 increased circulating thyroid-stimulating hormone level 0.655705056975393 0.837518012439687 0.569372500717094 0.384615384615385 7.2 7 2 decreased luteinizing hormone level 0.655705056975393 0.837518012439687 0.569372500717094 0.384615384615385 7.2 7 2 increased susceptibility to viral infection induced morbidity/mortality 0.659855760809422 0.840063032854948 0.566023250712876 0.382352941176471 7.2 7 2 increased vasoconstriction 0.661468472023613 0.840063032854948 0.563949905472169 0.380952380952381 7.2 7 2 hypoalgesia 0.661468472023613 0.840063032854948 0.563949905472169 0.380952380952381 7.2 7 2 abnormal stapes morphology 0.661468472023613 0.840063032854948 0.563949905472169 0.380952380952381 7.2 7 2 stomach inflammation 0.670137825720849 0.84169040216138 0.561519086914099 0.379310344827586 7.2 7 2 increased susceptibility to induced arthritis 0.670137825720849 0.84169040216138 0.561519086914099 0.379310344827586 7.2 7 2 abnormal vasodilation 0.683532308231056 0.856783379553919 0.555138188199167 0.375 7.2 7 2 delayed hair appearance 0.68056071893726 0.853273582840944 0.555138188199166 0.375 7.2 7 2 abnormal pituitary gland morphology 0.68056071893726 0.853273582840944 0.555138188199166 0.375 7.2 7 2 abnormal wound healing 0.68056071893726 0.853273582840944 0.555138188199166 0.375 7.2 7 2 increased circulating estradiol level 0.68056071893726 0.853273582840944 0.555138188199166 0.375 7.2 7 2 abnormal fertilization 0.68056071893726 0.853273582840944 0.555138188199166 0.375 7.2 7 2 abnormal urinary bladder physiology 0.68056071893726 0.853273582840944 0.555138188199166 0.375 7.2 7 2 dilated respiratory conducting tubes 0.68056071893726 0.853273582840944 0.555138188199166 0.375 7.2 7 2 abnormal cochlea morphology 0.733826271288336 0.908381612256649 0.548284630320164 0.37037037037037 7.2 7 2 abnormal nail morphology 0.70186461787337 0.872289901054214 0.545398921739532 0.368421052631579 7.2 7 2 flaky skin 0.70186461787337 0.872289901054214 0.545398921739532 0.368421052631579 7.2 7 2 abnormal inner ear vestibule morphology 0.737198558836691 0.912329062241924 0.5329326606712 0.36 7.2 7 2 abnormal kidney blood vessel morphology 0.728900310761706 0.902508473379664 0.528703036380159 0.357142857142857 7.2 7 2 abnormal uterus development 0.728900310761706 0.902508473379664 0.528703036380159 0.357142857142857 7.2 7 2 abnormal imprinting 0.728900310761706 0.902508473379664 0.528703036380159 0.357142857142857 7.2 7 2 enlarged stomach 0.728900310761706 0.902508473379664 0.528703036380159 0.357142857142857 7.2 7 2 increased B-1 B cell number 0.728900310761706 0.902508473379664 0.528703036380159 0.357142857142857 7.2 7 2 abnormal respiratory motile cilium physiology 0.728900310761706 0.902508473379664 0.528703036380159 0.357142857142857 7.2 7 2 decreased circulating progesterone level 0.752209711288298 0.927191472093499 0.528703036380159 0.357142857142857 7.2 7 2 abnormal cranial suture morphology 0.744779245259275 0.921481408894527 0.522483000658039 0.352941176470588 7.2 7 2 decreased susceptibility to injury 0.833567286119399 0.980377600104967 0.522483000658039 0.352941176470588 7.2 7 2 brain inflammation 0.759151871699026 0.927191472093499 0.518128975652555 0.35 7.2 7 2 abnormal fibula morphology 0.759151871699026 0.927191472093499 0.518128975652555 0.35 7.2 7 2 abnormal circulating cytokine level 0.759151871699026 0.927191472093499 0.518128975652555 0.35 7.2 7 2 abnormal retinal cone cell morphology 0.772262812561098 0.927191472093499 0.514910783257198 0.347826086956522 7.2 7 2 pancreas inflammation 0.772262812561098 0.927191472093499 0.514910783257198 0.347826086956522 7.2 7 2 abnormal crista ampullaris morphology 0.772262812561098 0.927191472093499 0.514910783257198 0.347826086956522 7.2 7 2 abnormal regulatory T cell physiology 0.772262812561098 0.927191472093499 0.514910783257198 0.347826086956522 7.2 7 2 decreased granulocyte number 0.795405440534324 0.935937101858624 0.510471897194636 0.344827586206897 7.2 7 2 abnormal malleus morphology 0.816628064726119 0.960682104992301 0.493456167288148 0.333333333333333 7.2 7 2 altered righting response 0.790057956429013 0.929864758276399 0.493456167288148 0.333333333333333 7.2 7 2 joint inflammation 0.790057956429013 0.929864758276399 0.493456167288148 0.333333333333333 7.2 7 2 decreased susceptibility to induced arthritis 0.887998973150229 1 0.493456167288148 0.333333333333333 7.2 7 2 abnormal body temperature homeostasis 0.864650979679335 1 0.477538226407885 0.32258064516129 7.2 7 2 decreased airway responsiveness 0.848801162544693 0.988942806477716 0.471026341502323 0.318181818181818 7.2 7 2 altered susceptibility to infection 0.843940862548878 0.985320553100818 0.467484790062456 0.315789473684211 7.2 7 2 abnormal intestinal absorption 0.839829428016174 0.984020585110802 0.462615156832639 0.3125 7.2 7 2 decreased cochlear coiling 0.839829428016174 0.984020585110802 0.462615156832639 0.3125 7.2 7 2 abnormal epididymis epithelium morphology 0.839829428016174 0.984020585110802 0.462615156832639 0.3125 7.2 7 2 sepsis 0.839829428016174 0.984020585110802 0.462615156832639 0.3125 7.2 7 2 abnormal pancreatic alpha cell morphology 0.839829428016174 0.984020585110802 0.462615156832639 0.3125 7.2 7 2 abnormal intestinal lipid absorption 0.839829428016174 0.984020585110802 0.462615156832639 0.3125 7.2 7 2 abnormal tectorial membrane morphology 0.884987940663772 1 0.455498000573675 0.307692307692308 7.2 7 2 abnormal tendon morphology 0.879433670831547 1 0.435402500548366 0.294117647058824 7.2 7 2 increased acute inflammation 0.909193173463648 1 0.422962429104127 0.285714285714286 7.2 7 2 decreased susceptibility to bacterial infection induced morbidity/mortality 0.969571024204251 1 0.382030581126308 0.258064516129032 7.2 7 2 increased urine calcium level 0.951980733987457 1 0.370092125466111 0.25 7.2 7 2 increased susceptibility to fungal infection 0.98239671335607 1 0.321819239535749 0.217391304347826 7.2 7 2 gastric polyps 0.00149304090530529 0.0202394509642883 2.67381416504224 1 8.2 8 2 abnormal olfactory cortex morphology 0.00149304090530529 0.0202394509642883 2.67381416504224 1 8.2 8 2 abnormal cerebellum lobule morphology 0.00149304090530529 0.0202394509642883 2.67381416504224 1 8.2 8 2 abnormal mitophagy 0.00149304090530529 0.0202394509642883 2.67381416504224 1 8.2 8 2 abnormal hippocampus granule cell morphology 8.17923291230738e-06 0.000260844126530316 2.67381416504223 1 8.2 8 2 chromatolysis 0.000406240588315179 0.00706659764639166 2.67381416504223 1 8.2 8 2 ectopic hippocampus pyramidal cells 0.000406240588315179 0.00706659764639166 2.67381416504223 1 8.2 8 2 fatigue 1.84215796728234e-05 0.000545519993287478 2.4307401500384 0.909090909090909 8.2 8 2 abnormal CNS synapse formation 0.000205177644514716 0.00406911691687737 2.37672370225976 0.888888888888889 8.2 8 2 colon polyps 0.000673724665605175 0.0107774283324301 2.33958739441196 0.875 8.2 8 2 abnormal cerebellum deep nucleus morphology 0.000673724665605175 0.0107774283324301 2.33958739441196 0.875 8.2 8 2 abnormal maxillary prominence morphology 0.000673724665605175 0.0107774283324301 2.33958739441196 0.875 8.2 8 2 broad head 0.00218053390611135 0.0269185016945508 2.29184071289334 0.857142857142857 8.2 8 2 mammary gland hyperplasia 0.00218053390611135 0.0269185016945508 2.29184071289334 0.857142857142857 8.2 8 2 abnormal oculomotor nerve morphology 0.00218053390611135 0.0269185016945508 2.29184071289334 0.857142857142857 8.2 8 2 abnormal brain ventricular system morphology 0.00218053390611135 0.0269185016945508 2.29184071289334 0.857142857142857 8.2 8 2 abnormal Purkinje cell innervation 0.00218053390611135 0.0269185016945508 2.29184071289334 0.857142857142857 8.2 8 2 axonal dystrophy 2.66188352309288e-05 0.000725699519248657 2.26245813965112 0.846153846153846 8.2 8 2 abnormal urethra morphology 0.00692704249025586 0.0626582479800416 2.22817847086853 0.833333333333333 8.2 8 2 hyperresponsive 0.00692704249025586 0.0626582479800416 2.22817847086853 0.833333333333333 8.2 8 2 jumpy 0.00692704249025586 0.0626582479800416 2.22817847086853 0.833333333333333 8.2 8 2 non-obstructive hydrocephaly 0.00692704249025586 0.0626582479800416 2.22817847086853 0.833333333333333 8.2 8 2 abnormal hippocampal fimbria morphology 0.00692704249025586 0.0626582479800416 2.22817847086853 0.833333333333333 8.2 8 2 liver cirrhosis 0.00692704249025586 0.0626582479800416 2.22817847086853 0.833333333333333 8.2 8 2 enlarged pancreas 0.00692704249025586 0.0626582479800416 2.22817847086853 0.833333333333333 8.2 8 2 delayed chorioallantoic fusion 0.00692704249025586 0.0626582479800416 2.22817847086853 0.833333333333333 8.2 8 2 abnormal olfactory bulb layer morphology 0.00692704249025586 0.0626582479800416 2.22817847086853 0.833333333333333 8.2 8 2 ketoaciduria 0.000778810996606931 0.0121460335677727 2.13905133203379 0.8 8.2 8 2 increased heart rate variability 0.000778810996606931 0.0121460335677727 2.13905133203379 0.8 8.2 8 2 thin ventricle myocardium compact layer 0.000778810996606931 0.0121460335677727 2.13905133203379 0.8 8.2 8 2 decreased germ cell number 3.96394157601976e-06 0.000134153805038764 2.11090591977019 0.789473684210526 8.2 8 2 testis degeneration 9.33984221669367e-05 0.0020651428901356 2.1008539868189 0.785714285714286 8.2 8 2 abnormal head movements 0.00231363923942178 0.027836878325899 2.07963323947729 0.777777777777778 8.2 8 2 decreased level of surface class I molecules 0.00231363923942178 0.027836878325899 2.07963323947729 0.777777777777778 8.2 8 2 abnormal NMDA-mediated synaptic currents 0.00231363923942178 0.027836878325899 2.07963323947729 0.777777777777778 8.2 8 2 increased neuronal precursor cell number 0.00231363923942178 0.027836878325899 2.07963323947729 0.777777777777778 8.2 8 2 retropulsion 0.00231363923942178 0.027836878325899 2.07963323947729 0.777777777777778 8.2 8 2 reduced AMPA-mediated synaptic currents 0.00231363923942178 0.027836878325899 2.07963323947729 0.777777777777778 8.2 8 2 abnormal tail movements 1.46626794015584e-06 5.65479302501962e-05 2.06612912753264 0.772727272727273 8.2 8 2 abnormal dorsal-ventral axis patterning 3.33716429432627e-05 0.000873810124435432 2.04468142032641 0.764705882352941 8.2 8 2 impaired somite development 9.46342376658002e-05 0.00208320943534228 2.00536062378168 0.75 8.2 8 2 decreased synaptic depression 0.000777512967723064 0.0121460335677727 2.00536062378168 0.75 8.2 8 2 decreased mammary gland epithelial cell proliferation 0.000777512967723064 0.0121460335677727 2.00536062378168 0.75 8.2 8 2 embryonic lethality between implantation and placentation, incomplete penetrance 0.000777512967723064 0.0121460335677727 2.00536062378168 0.75 8.2 8 2 decreased aerobic running capacity 0.00670096162762987 0.0618502487893481 2.00536062378168 0.75 8.2 8 2 abnormal choroid pigmentation 0.00670096162762987 0.0618502487893481 2.00536062378168 0.75 8.2 8 2 abnormal olfactory bulb glomerular layer morphology 0.00670096162762987 0.0618502487893481 2.00536062378168 0.75 8.2 8 2 abnormal olfactory bulb mitral cell layer morphology 0.00670096162762987 0.0618502487893481 2.00536062378168 0.75 8.2 8 2 abnormal anterior commissure pars posterior morphology 0.00670096162762987 0.0618502487893481 2.00536062378168 0.75 8.2 8 2 abnormal heart echocardiography feature 0.00670096162762987 0.0618502487893481 2.00536062378168 0.75 8.2 8 2 delayed intramembranous bone ossification 0.000263556393839372 0.00492929721560481 1.96079705436431 0.733333333333333 8.2 8 2 abnormal proximal-distal axis patterning 0.00217074944842159 0.0269185016945508 1.94459212003072 0.727272727272727 8.2 8 2 abnormal fear/anxiety-related behavior 0.00217074944842159 0.0269185016945508 1.94459212003072 0.727272727272727 8.2 8 2 decreased embryonic cilium length 0.00217074944842159 0.0269185016945508 1.94459212003072 0.727272727272727 8.2 8 2 increased effector memory CD8-positive, alpha-beta T cell number 9.00229658266267e-05 0.00200835988783618 1.93108800808606 0.722222222222222 8.2 8 2 abnormal circulating alanine transaminase level 0.0187933139506171 0.137293299418972 1.90986726074445 0.714285714285714 8.2 8 2 abnormal gastrulation movements 0.0187933139506171 0.137293299418972 1.90986726074445 0.714285714285714 8.2 8 2 abnormal melanocyte morphology 0.0187933139506171 0.137293299418972 1.90986726074445 0.714285714285714 8.2 8 2 abnormal sinus venosus morphology 0.0187933139506171 0.137293299418972 1.90986726074445 0.714285714285714 8.2 8 2 aorta coarctation 0.0187933139506171 0.137293299418972 1.90986726074445 0.714285714285714 8.2 8 2 increased cell nucleus count 0.0187933139506171 0.137293299418972 1.90986726074445 0.714285714285714 8.2 8 2 abnormal renal/urinary system physiology 0.0187933139506171 0.137293299418972 1.90986726074445 0.714285714285714 8.2 8 2 decreased DN2 thymocyte number 0.0187933139506171 0.137293299418972 1.90986726074445 0.714285714285714 8.2 8 2 focal dorsal hair loss 0.0187933139506171 0.137293299418972 1.90986726074445 0.714285714285714 8.2 8 2 coronary fistula 0.0187933139506171 0.137293299418972 1.90986726074445 0.714285714285714 8.2 8 2 abnormal conotruncal ridge morphology 0.0187933139506171 0.137293299418972 1.90986726074445 0.714285714285714 8.2 8 2 abnormal aortic valve cusp morphology 0.0187933139506171 0.137293299418972 1.90986726074445 0.714285714285714 8.2 8 2 thick pulmonary valve 0.0187933139506171 0.137293299418972 1.90986726074445 0.714285714285714 8.2 8 2 altered tumor pathology 0.0187933139506171 0.137293299418972 1.90986726074445 0.714285714285714 8.2 8 2 increased compact bone volume 0.0187933139506171 0.137293299418972 1.90986726074445 0.714285714285714 8.2 8 2 embryonic lethality at implantation, incomplete penetrance 0.0187933139506171 0.137293299418972 1.90986726074445 0.714285714285714 8.2 8 2 absent heart tube 0.0187933139506171 0.137293299418972 1.90986726074445 0.714285714285714 8.2 8 2 decreased CD8-positive, naive alpha-beta T cell number 0.0187933139506171 0.137293299418972 1.90986726074445 0.714285714285714 8.2 8 2 abnormal object recognition memory 4.91240088599737e-07 2.24212792732449e-05 1.89754553648159 0.709677419354839 8.2 8 2 absence seizures 0.00024166446499989 0.00462232222936842 1.88739823414746 0.705882352941177 8.2 8 2 increased brain size 0.00024166446499989 0.00462232222936842 1.88739823414746 0.705882352941177 8.2 8 2 abnormal synaptic transmission 1.29201713179749e-06 5.02170721147853e-05 1.87166991552956 0.7 8.2 8 2 abnormal grooming behavior 0.0058949051393231 0.0562901210520776 1.87166991552956 0.7 8.2 8 2 impaired social transmission of food preference 0.0058949051393231 0.0562901210520776 1.87166991552956 0.7 8.2 8 2 ventricular premature beat 0.0058949051393231 0.0562901210520776 1.87166991552956 0.7 8.2 8 2 abnormal hippocampus neuron morphology 0.0058949051393231 0.0562901210520776 1.87166991552956 0.7 8.2 8 2 lethality during fetal growth through weaning, complete penetrance 0.0058949051393231 0.0562901210520776 1.87166991552956 0.7 8.2 8 2 abnormal motor coordination/ balance 1.58088127928674e-18 3.7451830306912e-16 1.86356744836277 0.696969696969697 8.2 8 2 short premaxilla 0.00191463255113818 0.0248054607862303 1.85110211426001 0.692307692307692 8.2 8 2 abnormal CNS synaptic transmission 9.55291868980058e-18 2.06633784703295e-15 1.83655922447345 0.686868686868687 8.2 8 2 abnormal dendritic spine morphology 8.55768682754052e-10 7.09574866116901e-08 1.83497050542114 0.686274509803922 8.2 8 2 abnormal hippocampus pyramidal cell morphology 4.06722128206325e-07 1.89106783909015e-05 1.83347257031468 0.685714285714286 8.2 8 2 increased mammary gland tumor incidence 7.26781868947064e-05 0.0016510227388181 1.8230551125288 0.681818181818182 8.2 8 2 abnormal egg cylinder morphology 2.49030602644606e-05 0.000692138127461963 1.81819363222872 0.68 8.2 8 2 abnormal pup retrieval 0.00162972715122416 0.0217369774191426 1.78254277669482 0.666666666666667 8.2 8 2 myocarditis 0.00495722240981863 0.050537257149278 1.78254277669482 0.666666666666667 8.2 8 2 abnormal corticospinal tract morphology 0.00495722240981863 0.050537257149278 1.78254277669482 0.666666666666667 8.2 8 2 abnormal AMPA-mediated synaptic currents 0.00495722240981863 0.050537257149278 1.78254277669482 0.666666666666667 8.2 8 2 loss of dopaminergic neurons 0.00495722240981863 0.050537257149278 1.78254277669482 0.666666666666667 8.2 8 2 abnormal somatic nervous system physiology 0.00495722240981863 0.050537257149278 1.78254277669482 0.666666666666667 8.2 8 2 reduced cerebellar foliation 0.00495722240981863 0.050537257149278 1.78254277669482 0.666666666666667 8.2 8 2 prenatal growth retardation 0.00495722240981863 0.050537257149278 1.78254277669482 0.666666666666667 8.2 8 2 abnormal ion homeostasis 0.0154756064040461 0.121628976082353 1.78254277669482 0.666666666666667 8.2 8 2 abnormal germ cell morphology 0.0154756064040461 0.121628976082353 1.78254277669482 0.666666666666667 8.2 8 2 abnormal artery development 0.0154756064040461 0.121628976082353 1.78254277669482 0.666666666666667 8.2 8 2 decreased fear-related response 0.0154756064040461 0.121628976082353 1.78254277669482 0.666666666666667 8.2 8 2 positive geotaxis 0.0154756064040461 0.121628976082353 1.78254277669482 0.666666666666667 8.2 8 2 abnormal cerebellar layer morphology 0.0154756064040461 0.121628976082353 1.78254277669482 0.666666666666667 8.2 8 2 axonal spheroids 0.0154756064040461 0.121628976082353 1.78254277669482 0.666666666666667 8.2 8 2 increased core body temperature 0.0154756064040461 0.121628976082353 1.78254277669482 0.666666666666667 8.2 8 2 cerebellum atrophy 0.0154756064040461 0.121628976082353 1.78254277669482 0.666666666666667 8.2 8 2 abnormal learning/memory/conditioning 3.62195013575577e-09 2.57417170362642e-07 1.75013290802764 0.654545454545455 8.2 8 2 abnormal circulating enzyme level 0.000458265849533784 0.00783461375062054 1.73797920727745 0.65 8.2 8 2 decreased paired-pulse facilitation 0.000458265849533784 0.00783461375062054 1.73797920727745 0.65 8.2 8 2 spleen atrophy 0.000458265849533784 0.00783461375062054 1.73797920727745 0.65 8.2 8 2 impaired balance 2.88922788508027e-15 5.32366989936087e-13 1.73011504796851 0.647058823529412 8.2 8 2 impaired synaptic plasticity 5.45797553419347e-06 0.000178640975543503 1.73011504796851 0.647058823529412 8.2 8 2 abnormal embryonic-extraembryonic boundary morphology 0.00135663970352702 0.018851826832712 1.73011504796851 0.647058823529412 8.2 8 2 lethality at weaning, complete penetrance 1.99505755928665e-07 9.82713995787238e-06 1.72312468413833 0.644444444444444 8.2 8 2 astrocytosis 3.60771002040528e-11 3.90181681554702e-09 1.72149679119158 0.643835616438356 8.2 8 2 increased aggression towards males 0.00406686717984517 0.0433247627831472 1.71888053467001 0.642857142857143 8.2 8 2 abnormal voluntary movement 0.00406686717984517 0.0433247627831472 1.71888053467001 0.642857142857143 8.2 8 2 split sternum 0.00406686717984517 0.0433247627831472 1.71888053467001 0.642857142857143 8.2 8 2 increased pulmonary respiratory rate 0.00406686717984517 0.0433247627831472 1.71888053467001 0.642857142857143 8.2 8 2 increased stomach tumor incidence 0.00406686717984517 0.0433247627831472 1.71888053467001 0.642857142857143 8.2 8 2 increased coping response 0.000379928777734226 0.00672649704351522 1.70151810502688 0.636363636363636 8.2 8 2 abnormal vascular branching morphogenesis 0.000379928777734226 0.00672649704351522 1.70151810502688 0.636363636363636 8.2 8 2 abnormal limb posture 0.000379928777734226 0.00672649704351522 1.70151810502688 0.636363636363636 8.2 8 2 abnormal sphenoid bone morphology 0.0124121775984007 0.102229606054366 1.70151810502688 0.636363636363636 8.2 8 2 abnormal eye distance/ position 0.0124121775984007 0.102229606054366 1.70151810502688 0.636363636363636 8.2 8 2 decreased post-tetanic potentiation 0.0124121775984007 0.102229606054366 1.70151810502688 0.636363636363636 8.2 8 2 loss of cortex neurons 0.0124121775984007 0.102229606054366 1.70151810502688 0.636363636363636 8.2 8 2 impaired luteinization 0.0124121775984007 0.102229606054366 1.70151810502688 0.636363636363636 8.2 8 2 abnormal radial glial cell morphology 0.0124121775984007 0.102229606054366 1.70151810502688 0.636363636363636 8.2 8 2 abnormal spinal cord ventral horn morphology 0.0124121775984007 0.102229606054366 1.70151810502688 0.636363636363636 8.2 8 2 abnormal dorsal-ventral polarity of the somites 0.0124121775984007 0.102229606054366 1.70151810502688 0.636363636363636 8.2 8 2 increased number of Howell-Jolly bodies 0.0124121775984007 0.102229606054366 1.70151810502688 0.636363636363636 8.2 8 2 unresponsive to tactile stimuli 0.00111270317266606 0.0159991279884787 1.68872473581615 0.631578947368421 8.2 8 2 impaired limb coordination 4.20419641849855e-08 2.42794581863698e-06 1.683512622434 0.62962962962963 8.2 8 2 axon degeneration 4.20419641849855e-08 2.42794581863698e-06 1.683512622434 0.62962962962963 8.2 8 2 abnormal skin appearance 0.000108056713887803 0.00234752031262804 1.683512622434 0.62962962962963 8.2 8 2 abnormal embryonic epiblast morphology 1.09095185406728e-05 0.000335029967529921 1.68068318945512 0.628571428571429 8.2 8 2 increased hemangiosarcoma incidence 0.000311709919448531 0.00563911581547797 1.6711338531514 0.625 8.2 8 2 increased cochlear outer hair cell number 0.00328729717422903 0.0370006865198856 1.6711338531514 0.625 8.2 8 2 blepharitis 0.00328729717422903 0.0370006865198856 1.6711338531514 0.625 8.2 8 2 dystonia 0.00328729717422903 0.0370006865198856 1.6711338531514 0.625 8.2 8 2 decreased midbrain size 0.00328729717422903 0.0370006865198856 1.6711338531514 0.625 8.2 8 2 abnormal exoccipital bone morphology 0.0389472344889292 0.212458872349148 1.6711338531514 0.625 8.2 8 2 schistocytosis 0.0389472344889292 0.212458872349148 1.6711338531514 0.625 8.2 8 2 abnormal cecum morphology 0.0389472344889292 0.212458872349148 1.6711338531514 0.625 8.2 8 2 absent mammary gland 0.0389472344889292 0.212458872349148 1.6711338531514 0.625 8.2 8 2 increased sensitivity to skin irradiation 0.0389472344889292 0.212458872349148 1.6711338531514 0.625 8.2 8 2 dermal cysts 0.0389472344889292 0.212458872349148 1.6711338531514 0.625 8.2 8 2 abnormal atrial thrombosis 0.0389472344889292 0.212458872349148 1.6711338531514 0.625 8.2 8 2 hypospadia 0.0389472344889292 0.212458872349148 1.6711338531514 0.625 8.2 8 2 abnormal neuron apoptosis 0.0389472344889292 0.212458872349148 1.6711338531514 0.625 8.2 8 2 elevated level of mitotic sister chromatid exchange 0.0389472344889292 0.212458872349148 1.6711338531514 0.625 8.2 8 2 lymph node inflammation 0.0389472344889292 0.212458872349148 1.6711338531514 0.625 8.2 8 2 tau protein deposits 0.0389472344889292 0.212458872349148 1.6711338531514 0.625 8.2 8 2 abnormal extraembryonic tissue physiology 0.0389472344889292 0.212458872349148 1.6711338531514 0.625 8.2 8 2 small frontal bone 0.0389472344889292 0.212458872349148 1.6711338531514 0.625 8.2 8 2 abnormal kidney epithelium morphology 0.0389472344889292 0.212458872349148 1.6711338531514 0.625 8.2 8 2 accumulation of giant lysosomes in kidney/renal tubule cells 0.0389472344889292 0.212458872349148 1.6711338531514 0.625 8.2 8 2 craniofacial phenotype 0.0389472344889292 0.212458872349148 1.6711338531514 0.625 8.2 8 2 hypergranulosis 0.0389472344889292 0.212458872349148 1.6711338531514 0.625 8.2 8 2 skin fibrosis 0.0389472344889292 0.212458872349148 1.6711338531514 0.625 8.2 8 2 decreased hippocampus pyramidal cell number 0.0389472344889292 0.212458872349148 1.6711338531514 0.625 8.2 8 2 increased caudal vertebrae number 0.0389472344889292 0.212458872349148 1.6711338531514 0.625 8.2 8 2 pleural effusion 0.0389472344889292 0.212458872349148 1.6711338531514 0.625 8.2 8 2 myocardial trabeculae hypoplasia 0.0389472344889292 0.212458872349148 1.6711338531514 0.625 8.2 8 2 lung situs inversus 0.0389472344889292 0.212458872349148 1.6711338531514 0.625 8.2 8 2 decreased alveolar lamellar body number 0.0389472344889292 0.212458872349148 1.6711338531514 0.625 8.2 8 2 increased testis apoptosis 0.0389472344889292 0.212458872349148 1.6711338531514 0.625 8.2 8 2 increased mammary gland apoptosis 0.0389472344889292 0.212458872349148 1.6711338531514 0.625 8.2 8 2 seizures 4.9564815164097e-15 8.80660555147794e-13 1.66527022559648 0.62280701754386 8.2 8 2 abnormal axon morphology 3.79957139988725e-14 5.9071461607622e-12 1.65875508386879 0.62037037037037 8.2 8 2 abnormal axon extension 2.7506959690706e-07 1.34163847511041e-05 1.65776478232619 0.62 8.2 8 2 decreased exploration in new environment 2.98024347954486e-11 3.29482473571904e-09 1.65521829264519 0.619047619047619 8.2 8 2 abnormal embryonic/fetal subventricular zone morphology 0.000903288634008024 0.0136823199975425 1.65521829264519 0.619047619047619 8.2 8 2 ataxia 5.72141896483207e-25 2.58764175909451e-22 1.65458797341722 0.618811881188119 8.2 8 2 abnormal contextual conditioning behavior 8.12620152811827e-08 4.30083538323281e-06 1.65290330202611 0.618181818181818 8.2 8 2 abnormal cell nucleus morphology 7.70638705324903e-07 3.33385005129686e-05 1.64980022949415 0.617021276595745 8.2 8 2 heart inflammation 0.00025373536522343 0.00478156606813093 1.64542410156445 0.615384615384615 8.2 8 2 increased thymocyte apoptosis 0.00025373536522343 0.00478156606813093 1.64542410156445 0.615384615384615 8.2 8 2 excessive scratching 0.00982536618370732 0.0845695445742974 1.64542410156445 0.615384615384615 8.2 8 2 abnormal grip strength 0.00982536618370732 0.0845695445742974 1.64542410156445 0.615384615384615 8.2 8 2 increased synaptic depression 0.00982536618370732 0.0845695445742974 1.64542410156445 0.615384615384615 8.2 8 2 muscle fatigue 0.00982536618370732 0.0845695445742974 1.64542410156445 0.615384615384615 8.2 8 2 absent hypoglossal nerve 0.00982536618370732 0.0845695445742974 1.64542410156445 0.615384615384615 8.2 8 2 neurodegeneration 1.86415742103496e-07 9.27418316964893e-06 1.63399754530359 0.611111111111111 8.2 8 2 reduced long term depression 2.08336625675614e-05 0.000595675122262173 1.63399754530359 0.611111111111111 8.2 8 2 abnormal lysosome morphology 2.08336625675614e-05 0.000595675122262173 1.63399754530359 0.611111111111111 8.2 8 2 abnormal thymus cortex morphology 0.00263215608095368 0.0308843785442089 1.63399754530359 0.611111111111111 8.2 8 2 decreased lactate dehydrogenase level 0.00263215608095368 0.0308843785442089 1.63399754530359 0.611111111111111 8.2 8 2 abnormal pregnancy 0.00263215608095368 0.0308843785442089 1.63399754530359 0.611111111111111 8.2 8 2 abnormal erythropoiesis 4.5322919468109e-13 6.26337567649562e-11 1.62975339583527 0.60952380952381 8.2 8 2 failure to gastrulate 1.76630589993199e-06 6.55774018818032e-05 1.62753905698223 0.608695652173913 8.2 8 2 myoclonus 0.00020529614997713 0.00406911691687737 1.62338717163279 0.607142857142857 8.2 8 2 straub tail 0.00020529614997713 0.00406911691687737 1.62338717163279 0.607142857142857 8.2 8 2 abnormal brain vasculature morphology 0.000165317977275176 0.00338459644832922 1.60428849902534 0.6 8.2 8 2 anencephaly 0.00209435915736448 0.0264452710860109 1.60428849902534 0.6 8.2 8 2 abnormal hearing physiology 0.00209435915736448 0.0264452710860109 1.60428849902534 0.6 8.2 8 2 macrocytosis 0.00772257722277671 0.0681202512115499 1.60428849902534 0.6 8.2 8 2 abnormal trophectoderm morphology 0.00772257722277671 0.0681202512115499 1.60428849902534 0.6 8.2 8 2 abnormal olfactory nerve morphology 0.00772257722277671 0.0681202512115499 1.60428849902534 0.6 8.2 8 2 immune system phenotype 0.00772257722277671 0.0681202512115499 1.60428849902534 0.6 8.2 8 2 abnormal neurotransmitter secretion 0.00772257722277671 0.0681202512115499 1.60428849902534 0.6 8.2 8 2 enlarged testis 0.0298466583011306 0.178684867687274 1.60428849902534 0.6 8.2 8 2 fused cornea and lens 0.0298466583011306 0.178684867687274 1.60428849902534 0.6 8.2 8 2 absent trophoblast giant cells 0.0298466583011306 0.178684867687274 1.60428849902534 0.6 8.2 8 2 abnormal PNS synaptic transmission 0.0298466583011306 0.178684867687274 1.60428849902534 0.6 8.2 8 2 acrania 0.0298466583011306 0.178684867687274 1.60428849902534 0.6 8.2 8 2 abnormal spinal cord dorsal column morphology 0.0298466583011306 0.178684867687274 1.60428849902534 0.6 8.2 8 2 abnormal cerebellar granule cell migration 0.0298466583011306 0.178684867687274 1.60428849902534 0.6 8.2 8 2 aorta stenosis 0.0298466583011306 0.178684867687274 1.60428849902534 0.6 8.2 8 2 decreased macrophage cytokine production 0.0298466583011306 0.178684867687274 1.60428849902534 0.6 8.2 8 2 decreased circulating total protein level 3.44146332336968e-07 1.63059809845373e-05 1.60428849902534 0.6 8.2 8 2 short stride length 1.17027289405284e-06 4.58433673064004e-05 1.60428849902534 0.6 8.2 8 2 abnormal nest building behavior 0.000583369977552488 0.00964207853263664 1.60428849902534 0.6 8.2 8 2 abnormal cell morphology 3.75101783801185e-13 5.33180392688828e-11 1.59490669493747 0.596491228070175 8.2 8 2 liver hypoplasia 9.48535309243294e-07 3.83655541746779e-05 1.59400459839056 0.596153846153846 8.2 8 2 absent corpus luteum 9.48535309243294e-07 3.83655541746779e-05 1.59400459839056 0.596153846153846 8.2 8 2 abnormal brain wave pattern 9.48535309243294e-07 3.83655541746779e-05 1.59400459839056 0.596153846153846 8.2 8 2 abnormal heart atrium morphology 0.000132623700520181 0.00279577504274533 1.58757716049383 0.59375 8.2 8 2 abnormal auditory brainstem response waveform shape 0.000132623700520181 0.00279577504274533 1.58757716049383 0.59375 8.2 8 2 abnormal trigeminal nerve morphology 0.000465631585347977 0.0078793099901571 1.58448246817318 0.592592592592593 8.2 8 2 increased brain weight 0.000465631585347977 0.0078793099901571 1.58448246817318 0.592592592592593 8.2 8 2 abnormal brain commissure morphology 0.000465631585347977 0.0078793099901571 1.58448246817318 0.592592592592593 8.2 8 2 abnormal motor capabilities/coordination/movement 1.48118546391441e-14 2.54099920102559e-12 1.57998109752496 0.590909090909091 8.2 8 2 embryonic lethality before implantation, incomplete penetrance 0.00165925287084795 0.0220127547532495 1.57998109752496 0.590909090909091 8.2 8 2 aminoaciduria 0.0060453792752319 0.0574644811138759 1.57283186178955 0.588235294117647 8.2 8 2 enhanced behavioral response to cocaine 0.0060453792752319 0.0574644811138759 1.57283186178955 0.588235294117647 8.2 8 2 limb grasping 3.4972335258592e-19 9.1572298900787e-17 1.5719676684589 0.587912087912088 8.2 8 2 decreased circulating serum albumin level 5.46951239606623e-11 5.78953705753819e-09 1.5664769855803 0.585858585858586 8.2 8 2 abnormal action potential 3.52904560402618e-08 2.16753109630003e-06 1.56609115381045 0.585714285714286 8.2 8 2 abnormal nervous system electrophysiology 2.03875068906643e-09 1.60996582192151e-07 1.55972492960797 0.583333333333333 8.2 8 2 vertebral transformation 5.74472973975826e-06 0.000186797584675146 1.55972492960797 0.583333333333333 8.2 8 2 abnormal pharyngeal arch morphology 8.46273917782427e-05 0.00189649222566107 1.55972492960797 0.583333333333333 8.2 8 2 abnormal nursing 0.00131054679252056 0.0184179951773723 1.55972492960797 0.583333333333333 8.2 8 2 hemolytic anemia 0.00131054679252056 0.0184179951773723 1.55972492960797 0.583333333333333 8.2 8 2 abnormal impulse conducting system conduction 0.00131054679252056 0.0184179951773723 1.55972492960797 0.583333333333333 8.2 8 2 abnormal mating frequency 0.0228491148624157 0.147056075602223 1.55972492960797 0.583333333333333 8.2 8 2 abnormal thymus involution 0.0228491148624157 0.147056075602223 1.55972492960797 0.583333333333333 8.2 8 2 increased fear-related response 0.0228491148624157 0.147056075602223 1.55972492960797 0.583333333333333 8.2 8 2 abnormal vascular endothelial cell development 0.0228491148624157 0.147056075602223 1.55972492960797 0.583333333333333 8.2 8 2 increased osteosarcoma incidence 0.0228491148624157 0.147056075602223 1.55972492960797 0.583333333333333 8.2 8 2 pale placenta 0.0228491148624157 0.147056075602223 1.55972492960797 0.583333333333333 8.2 8 2 decreased prostaglandin level 0.0228491148624157 0.147056075602223 1.55972492960797 0.583333333333333 8.2 8 2 abnormal pulmonary valve cusp morphology 0.0228491148624157 0.147056075602223 1.55972492960797 0.583333333333333 8.2 8 2 abnormal vitelline vein connection 0.0228491148624157 0.147056075602223 1.55972492960797 0.583333333333333 8.2 8 2 abnormal cell cycle 2.59690376423151e-12 3.31271698129532e-10 1.55778738311156 0.582608695652174 8.2 8 2 impaired coordination 9.63555099529261e-34 6.84812374308296e-31 1.55328510743783 0.580924855491329 8.2 8 2 increased neuron apoptosis 5.48960876070981e-09 3.79316716451823e-07 1.5514724167529 0.580246913580247 8.2 8 2 increased B cell derived lymphoma incidence 4.59770601899828e-06 0.000153514009694741 1.5508122157245 0.58 8.2 8 2 impaired righting response 3.18711136158963e-10 3.04920750459777e-08 1.54799767449814 0.578947368421053 8.2 8 2 increased hepatocellular carcinoma incidence 1.08572050972532e-06 4.32116762870677e-05 1.54799767449814 0.578947368421053 8.2 8 2 increased liver adenoma incidence 0.00472140382984916 0.0490375449968676 1.54799767449814 0.578947368421053 8.2 8 2 right-sided stomach 0.00472140382984916 0.0490375449968676 1.54799767449814 0.578947368421053 8.2 8 2 abnormal locomotor behavior 8.52907719985178e-10 7.09574866116901e-08 1.5403494646439 0.576086956521739 8.2 8 2 abnormal locomotor coordination 0.000232970872151654 0.0045452160351156 1.53946876169098 0.575757575757576 8.2 8 2 neuron degeneration 1.24732460008123e-05 0.000378380480817324 1.53602090332214 0.574468085106383 8.2 8 2 embryonic lethality between implantation and somite formation, complete penetrance 5.44123786112683e-23 1.8046772239404e-20 1.52789380859556 0.571428571428571 8.2 8 2 shortened head 0.000812745499175777 0.0124796569703688 1.52789380859556 0.571428571428571 8.2 8 2 lymphoid hyperplasia 0.000812745499175777 0.0124796569703688 1.52789380859556 0.571428571428571 8.2 8 2 failure of blastocyst to hatch from the zona pellucida 0.000812745499175777 0.0124796569703688 1.52789380859556 0.571428571428571 8.2 8 2 premature aging 0.000812745499175777 0.0124796569703688 1.52789380859556 0.571428571428571 8.2 8 2 increased hemangioma incidence 0.0175033648555235 0.132339270754148 1.52789380859556 0.571428571428571 8.2 8 2 absent otoliths 0.0175033648555235 0.132339270754148 1.52789380859556 0.571428571428571 8.2 8 2 lysosomal protein accumulation 0.0175033648555235 0.132339270754148 1.52789380859556 0.571428571428571 8.2 8 2 spina bifida occulta 0.0175033648555235 0.132339270754148 1.52789380859556 0.571428571428571 8.2 8 2 embryonic lethality between somite formation and embryo turning, complete penetrance 1.31979972402364e-07 6.70000370103836e-06 1.52789380859556 0.571428571428571 8.2 8 2 absent mesoderm 1.48043962787642e-06 5.66552857591167e-05 1.5151613601906 0.566666666666667 8.2 8 2 abnormal neuron morphology 7.4373015296766e-10 6.56913375403173e-08 1.51246053780167 0.565656565656566 8.2 8 2 abnormal cell death 2.66940727683425e-05 0.000725699519248657 1.51128626719779 0.565217391304348 8.2 8 2 abnormal hematopoietic stem cell physiology 0.00287002206808651 0.0331284449854534 1.51128626719779 0.565217391304348 8.2 8 2 abnormal excitatory postsynaptic currents 5.33443477812726e-08 2.99749685032745e-06 1.50830542643408 0.564102564102564 8.2 8 2 abnormal craniofacial morphology 4.73332344816906e-10 4.44307248200775e-08 1.50564292788786 0.563106796116505 8.2 8 2 abnormal posture 4.24585499942547e-08 2.42794581863698e-06 1.50402046783626 0.5625 8.2 8 2 increased fibroblast apoptosis 0.000501652166333319 0.00837489774331631 1.50402046783626 0.5625 8.2 8 2 reduced male mating frequency 0.013425080142338 0.108895863639827 1.50402046783626 0.5625 8.2 8 2 abnormal olfaction 0.013425080142338 0.108895863639827 1.50402046783626 0.5625 8.2 8 2 enlarged liver sinusoidal spaces 0.000393708736947382 0.00690576746075853 1.49419026870007 0.558823529411765 8.2 8 2 abnormal direction of heart looping 0.000393708736947382 0.00690576746075853 1.49419026870007 0.558823529411765 8.2 8 2 abnormal axon guidance 7.14260045893214e-05 0.0016436151870519 1.49236139444218 0.558139534883721 8.2 8 2 abnormal behavior 8.86764340429817e-24 3.15118042402738e-21 1.49079566755952 0.557553956834532 8.2 8 2 increased tumor incidence 2.33044998974214e-11 2.82780212169931e-09 1.48784820474124 0.556451612903226 8.2 8 2 abnormal apoptosis 1.04269642384697e-05 0.000324213419289916 1.48545231391235 0.555555555555556 8.2 8 2 decreased circulating fructosamine level 0.00174192189199956 0.022865597394981 1.48545231391235 0.555555555555556 8.2 8 2 increased gastrointestinal tumor incidence 0.0103119082680797 0.0881376161069911 1.48545231391235 0.555555555555556 8.2 8 2 increased effector memory CD4-positive, alpha-beta T cell number 0.0103119082680797 0.0881376161069911 1.48545231391235 0.555555555555556 8.2 8 2 abnormal hypoglossal nerve topology 0.0103119082680797 0.0881376161069911 1.48545231391235 0.555555555555556 8.2 8 2 thick tail 0.0682867695950332 0.29580563413186 1.48545231391235 0.555555555555556 8.2 8 2 increased pheochromocytoma incidence 0.0682867695950332 0.29580563413186 1.48545231391235 0.555555555555556 8.2 8 2 abnormal vomeronasal organ morphology 0.0682867695950332 0.29580563413186 1.48545231391235 0.555555555555556 8.2 8 2 abnormal posterior semicircular canal morphology 0.0682867695950332 0.29580563413186 1.48545231391235 0.555555555555556 8.2 8 2 abnormal thymus physiology 0.0682867695950332 0.29580563413186 1.48545231391235 0.555555555555556 8.2 8 2 decreased cellular sensitivity to ionizing radiation 0.0682867695950332 0.29580563413186 1.48545231391235 0.555555555555556 8.2 8 2 enhanced conditioned place preference behavior 0.0682867695950332 0.29580563413186 1.48545231391235 0.555555555555556 8.2 8 2 multiflagellated sperm 0.0682867695950332 0.29580563413186 1.48545231391235 0.555555555555556 8.2 8 2 abnormal telomere morphology 0.0682867695950332 0.29580563413186 1.48545231391235 0.555555555555556 8.2 8 2 abnormal ventricle myocardium morphology 0.0682867695950332 0.29580563413186 1.48545231391235 0.555555555555556 8.2 8 2 decreased effector memory CD4-positive, alpha-beta T cell number 0.0682867695950332 0.29580563413186 1.48545231391235 0.555555555555556 8.2 8 2 decreased pancreatic beta cell proliferation 0.0682867695950332 0.29580563413186 1.48545231391235 0.555555555555556 8.2 8 2 abnormal ductus venosus valve topology 0.0682867695950332 0.29580563413186 1.48545231391235 0.555555555555556 8.2 8 2 abnormal infrahyoid muscle connection 0.0682867695950332 0.29580563413186 1.48545231391235 0.555555555555556 8.2 8 2 increased cardiac muscle glycogen level 0.0682867695950332 0.29580563413186 1.48545231391235 0.555555555555556 8.2 8 2 increased endoplasmic reticulum stress 0.0682867695950332 0.29580563413186 1.48545231391235 0.555555555555556 8.2 8 2 reduced long term potentiation 3.13612432231946e-10 3.04920750459777e-08 1.48014712707695 0.553571428571429 8.2 8 2 increased cellular sensitivity to gamma-irradiation 4.4300810670999e-05 0.00109650016461801 1.47913124023613 0.553191489361702 8.2 8 2 abnormal innervation 4.4300810670999e-05 0.00109650016461801 1.47913124023613 0.553191489361702 8.2 8 2 increased grooming behavior 0.000242209221050166 0.00462232222936842 1.47763414383913 0.552631578947368 8.2 8 2 decreased threshold for auditory brainstem response 0.000242209221050166 0.00462232222936842 1.47763414383913 0.552631578947368 8.2 8 2 lordosis 0.00135705787692942 0.018851826832712 1.47520781519572 0.551724137931034 8.2 8 2 abnormal embryonic erythropoiesis 0.00135705787692942 0.018851826832712 1.47520781519572 0.551724137931034 8.2 8 2 small liver 1.83526407166654e-07 9.22266541064754e-06 1.47402575765149 0.551282051282051 8.2 8 2 abnormal sperm mitochondrial sheath morphology 0.00793223620733044 0.0697223942252101 1.47059779077323 0.55 8.2 8 2 increased skin tumor incidence 0.00793223620733044 0.0697223942252101 1.47059779077323 0.55 8.2 8 2 abnormal cued conditioning behavior 2.74374156312811e-05 0.000733877111643137 1.46797640433691 0.549019607843137 8.2 8 2 abnormal response to novel object 2.74374156312811e-05 0.000733877111643137 1.46797640433691 0.549019607843137 8.2 8 2 absent mature ovarian follicles 0.00105738693497852 0.0154360623758822 1.46628518728123 0.548387096774194 8.2 8 2 abnormal eyelid morphology 0.00105738693497852 0.0154360623758822 1.46628518728123 0.548387096774194 8.2 8 2 inner cell mass degeneration 0.00105738693497852 0.0154360623758822 1.46628518728123 0.548387096774194 8.2 8 2 abnormal abdominal fat pad morphology 0.00611029356969655 0.0574644811138759 1.45844409002304 0.545454545454545 8.2 8 2 abnormal channel response 0.00611029356969655 0.0574644811138759 1.45844409002304 0.545454545454545 8.2 8 2 abnormal retinal outer plexiform layer morphology 0.00611029356969655 0.0574644811138759 1.45844409002304 0.545454545454545 8.2 8 2 cleft upper lip 0.00611029356969655 0.0574644811138759 1.45844409002304 0.545454545454545 8.2 8 2 abnormal cerebral cortex pyramidal cell morphology 0.00611029356969655 0.0574644811138759 1.45844409002304 0.545454545454545 8.2 8 2 increased bone volume 0.00611029356969655 0.0574644811138759 1.45844409002304 0.545454545454545 8.2 8 2 abnormal sebaceous gland morphology 0.0507680351444063 0.256141234641433 1.45844409002304 0.545454545454545 8.2 8 2 social withdrawal 0.0507680351444063 0.256141234641433 1.45844409002304 0.545454545454545 8.2 8 2 abnormal hemoglobin 0.0507680351444063 0.256141234641433 1.45844409002304 0.545454545454545 8.2 8 2 abnormal superovulation 0.0507680351444063 0.256141234641433 1.45844409002304 0.545454545454545 8.2 8 2 abnormal palate development 0.0507680351444063 0.256141234641433 1.45844409002304 0.545454545454545 8.2 8 2 enhanced behavioral response to addictive substance 0.0507680351444063 0.256141234641433 1.45844409002304 0.545454545454545 8.2 8 2 palatal shelf hypoplasia 0.0507680351444063 0.256141234641433 1.45844409002304 0.545454545454545 8.2 8 2 decreased palatine bone horizontal plate size 0.0507680351444063 0.256141234641433 1.45844409002304 0.545454545454545 8.2 8 2 common atrioventricular valve 0.0507680351444063 0.256141234641433 1.45844409002304 0.545454545454545 8.2 8 2 abnormal pulmonary alveolar sac morphology 0.0507680351444063 0.256141234641433 1.45844409002304 0.545454545454545 8.2 8 2 abnormal phrenic nerve innervation pattern to diaphragm 0.0507680351444063 0.256141234641433 1.45844409002304 0.545454545454545 8.2 8 2 thin hypoglossal nerve 0.0507680351444063 0.256141234641433 1.45844409002304 0.545454545454545 8.2 8 2 abnormal sleep pattern 9.14656078607736e-05 0.00203143481744352 1.45315987230556 0.543478260869565 8.2 8 2 pallor 3.50651107303191e-14 5.62738470591411e-12 1.45149911816578 0.542857142857143 8.2 8 2 abnormal liver development 0.000642401256256873 0.0103764488632401 1.45149911816578 0.542857142857143 8.2 8 2 increased carcinoma incidence 0.000642401256256873 0.0103764488632401 1.45149911816578 0.542857142857143 8.2 8 2 embryonic lethality, complete penetrance 1.55725124079617e-24 6.45610410246747e-22 1.4500622274367 0.542319749216301 8.2 8 2 small heart 7.16913558975402e-05 0.0016436151870519 1.44831600606454 0.541666666666667 8.2 8 2 ocular hypertelorism 0.00471303830284629 0.0490375449968676 1.44831600606454 0.541666666666667 8.2 8 2 blindness 0.00471303830284629 0.0490375449968676 1.44831600606454 0.541666666666667 8.2 8 2 prolonged QT interval 0.00471303830284629 0.0490375449968676 1.44831600606454 0.541666666666667 8.2 8 2 increased body temperature 0.00471303830284629 0.0490375449968676 1.44831600606454 0.541666666666667 8.2 8 2 abnormal maternal nurturing 8.25341864310966e-06 0.000261533488850131 1.44648963026875 0.540983606557377 8.2 8 2 malocclusion 0.00050092416594071 0.00837489774331631 1.44530495407688 0.540540540540541 8.2 8 2 decreased width of hypertrophic chondrocyte zone 0.00050092416594071 0.00837489774331631 1.44530495407688 0.540540540540541 8.2 8 2 decreased oocyte number 5.61929024065296e-05 0.00134403696861771 1.44385964912281 0.54 8.2 8 2 increased anxiety-related response 2.43984331473486e-11 2.89005249781094e-09 1.44270548473502 0.539568345323741 8.2 8 2 decreased kidney weight 4.40464406459502e-05 0.00109650016461801 1.4397460888689 0.538461538461538 8.2 8 2 ventricular hypoplasia 0.00363974619831117 0.0398848840013173 1.4397460888689 0.538461538461538 8.2 8 2 increased susceptibility to otitis media 0.00363974619831117 0.0398848840013173 1.4397460888689 0.538461538461538 8.2 8 2 decreased circulating glycerol level 0.00363974619831117 0.0398848840013173 1.4397460888689 0.538461538461538 8.2 8 2 abnormal digestion 0.0380434883209088 0.212458872349148 1.4397460888689 0.538461538461538 8.2 8 2 lymphoid hypoplasia 0.0380434883209088 0.212458872349148 1.4397460888689 0.538461538461538 8.2 8 2 abnormal pulmonary alveolus epithelial cell morphology 0.0380434883209088 0.212458872349148 1.4397460888689 0.538461538461538 8.2 8 2 abnormal tail bud morphology 0.0380434883209088 0.212458872349148 1.4397460888689 0.538461538461538 8.2 8 2 abnormal coping response 0.0380434883209088 0.212458872349148 1.4397460888689 0.538461538461538 8.2 8 2 tracheoesophageal fistula 0.0380434883209088 0.212458872349148 1.4397460888689 0.538461538461538 8.2 8 2 abnormal retinal inner plexiform layer morphology 0.0380434883209088 0.212458872349148 1.4397460888689 0.538461538461538 8.2 8 2 increased cochlear inner hair cell number 0.0380434883209088 0.212458872349148 1.4397460888689 0.538461538461538 8.2 8 2 abnormal vertebral arch development 0.0380434883209088 0.212458872349148 1.4397460888689 0.538461538461538 8.2 8 2 abnormal aorta tunica media morphology 0.0380434883209088 0.212458872349148 1.4397460888689 0.538461538461538 8.2 8 2 abnormal locomotor activation 7.15130912173431e-08 3.9096442725965e-06 1.4397460888689 0.538461538461538 8.2 8 2 abnormal social investigation 4.729667875699e-07 2.17871274829653e-05 1.4371751137102 0.5375 8.2 8 2 abnormal neuronal precursor proliferation 3.45272344847977e-05 0.000899335034355334 1.43593723678194 0.537037037037037 8.2 8 2 abnormal excitatory postsynaptic potential 3.72426726421651e-07 1.74794619240351e-05 1.43472955197388 0.536585365853659 8.2 8 2 abnormal cell differentiation 0.000304854563683283 0.00555699156329163 1.43472955197388 0.536585365853659 8.2 8 2 abnormal ovulation 0.00281404849910391 0.0325578867047487 1.43240044555834 0.535714285714286 8.2 8 2 absent corpus callosum 0.00281404849910391 0.0325578867047487 1.43240044555834 0.535714285714286 8.2 8 2 abnormal brainstem morphology 0.00281404849910391 0.0325578867047487 1.43240044555834 0.535714285714286 8.2 8 2 preweaning lethality, complete penetrance 1.25254916172409e-52 3.11571603978869e-49 1.43085190453611 0.535135135135135 8.2 8 2 decreased cell proliferation 3.44723534779236e-14 5.62738470591411e-12 1.43085190453611 0.535135135135135 8.2 8 2 abnormal double-strand DNA break repair 0.000237930650435654 0.00462232222936842 1.43017966967375 0.534883720930233 8.2 8 2 abnormal embryonic neuroepithelium morphology 2.12201570856552e-05 0.000603258751435056 1.42910757097085 0.53448275862069 8.2 8 2 decreased embryo size 5.92678546022853e-34 4.91429294410615e-31 1.42640713825475 0.53347280334728 8.2 8 2 abnormal myocardial trabeculae morphology 0.000185754011250001 0.0037305577922476 1.42603422135586 0.533333333333333 8.2 8 2 enhanced paired-pulse facilitation 0.00217792884363116 0.0269185016945508 1.42603422135586 0.533333333333333 8.2 8 2 abnormal prostate gland morphology 0.028681407864377 0.174224669261631 1.42603422135586 0.533333333333333 8.2 8 2 abnormal seizure response to electrical stimulation 0.028681407864377 0.174224669261631 1.42603422135586 0.533333333333333 8.2 8 2 decreased aggression towards males 0.028681407864377 0.174224669261631 1.42603422135586 0.533333333333333 8.2 8 2 abnormal placenta size 0.028681407864377 0.174224669261631 1.42603422135586 0.533333333333333 8.2 8 2 heterochrony 0.028681407864377 0.174224669261631 1.42603422135586 0.533333333333333 8.2 8 2 failure of primitive streak formation 0.00168721967277641 0.0222650341434022 1.42046377517869 0.53125 8.2 8 2 abnormal depression-related behavior 0.00168721967277641 0.0222650341434022 1.42046377517869 0.53125 8.2 8 2 abnormal gait 4.99556444068698e-22 1.46193724073046e-19 1.41911172513568 0.530744336569579 8.2 8 2 abnormal neural tube closure 5.84108432901345e-07 2.57162783511875e-05 1.41744365375733 0.530120481927711 8.2 8 2 decreased startle reflex 3.23544569893223e-09 2.36460126289608e-07 1.41689297634717 0.52991452991453 8.2 8 2 abnormal nervous system development 0.00130822582455574 0.0184179951773723 1.4155486756106 0.529411764705882 8.2 8 2 abnormal glutamate-mediated receptor currents 0.0217272436178324 0.141483032720833 1.4155486756106 0.529411764705882 8.2 8 2 abnormal involuntary movement 0.0217272436178324 0.141483032720833 1.4155486756106 0.529411764705882 8.2 8 2 abnormal melanosome morphology 0.0217272436178324 0.141483032720833 1.4155486756106 0.529411764705882 8.2 8 2 coloboma 0.0217272436178324 0.141483032720833 1.4155486756106 0.529411764705882 8.2 8 2 atrioventricular septal defect 6.92038177983064e-05 0.00160882707264754 1.4125810683242 0.528301886792453 8.2 8 2 abnormal forebrain development 3.87209886774594e-06 0.000131943094979699 1.41117969821674 0.527777777777778 8.2 8 2 abnormal head morphology 5.41027174435594e-05 0.00131298058186199 1.40982928702227 0.527272727272727 8.2 8 2 abnormal embryo turning 5.41027174435594e-05 0.00131298058186199 1.40982928702227 0.527272727272727 8.2 8 2 decreased brain weight 4.23073900291558e-05 0.00106842266697995 1.40727061318012 0.526315789473684 8.2 8 2 abnormal retinal outer nuclear layer morphology 0.000788385215819087 0.0122569264021874 1.40727061318012 0.526315789473684 8.2 8 2 abnormal stationary movement 0.0165235798661136 0.126663805599253 1.40727061318012 0.526315789473684 8.2 8 2 decreased grooming behavior 0.0165235798661136 0.126663805599253 1.40727061318012 0.526315789473684 8.2 8 2 abnormal long term depression 0.0165235798661136 0.126663805599253 1.40727061318012 0.526315789473684 8.2 8 2 increased malignant tumor incidence 0.0165235798661136 0.126663805599253 1.40727061318012 0.526315789473684 8.2 8 2 abnormal nasal septum morphology 0.0165235798661136 0.126663805599253 1.40727061318012 0.526315789473684 8.2 8 2 increased susceptibility to ischemic brain injury 0.0165235798661136 0.126663805599253 1.40727061318012 0.526315789473684 8.2 8 2 abnormal digestive system development 0.0165235798661136 0.126663805599253 1.40727061318012 0.526315789473684 8.2 8 2 abnormal sternebra morphology 0.0165235798661136 0.126663805599253 1.40727061318012 0.526315789473684 8.2 8 2 decreased liver regeneration 0.0165235798661136 0.126663805599253 1.40727061318012 0.526315789473684 8.2 8 2 decreased circulating magnesium level 0.0165235798661136 0.126663805599253 1.40727061318012 0.526315789473684 8.2 8 2 increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 0.0165235798661136 0.126663805599253 1.40727061318012 0.526315789473684 8.2 8 2 disheveled coat 0.000476437555230381 0.00803483673651236 1.40056932454593 0.523809523809524 8.2 8 2 abnormal eye pigmentation 0.0126069975280369 0.102988198197017 1.40056932454593 0.523809523809524 8.2 8 2 left pulmonary isomerism 0.0126069975280369 0.102988198197017 1.40056932454593 0.523809523809524 8.2 8 2 embryonic lethality at implantation, complete penetrance 0.0126069975280369 0.102988198197017 1.40056932454593 0.523809523809524 8.2 8 2 gliosis 2.02588517633508e-05 0.000585975508852733 1.40056932454593 0.523809523809524 8.2 8 2 double outlet right ventricle 3.25323707596315e-08 2.02310680661458e-06 1.39937937609687 0.523364485981308 8.2 8 2 abnormal nervous system physiology 1.24334944289131e-08 8.35900470051927e-07 1.39503347741334 0.521739130434783 8.2 8 2 microcephaly 9.71942583751872e-06 0.000304114110324878 1.39503347741334 0.521739130434783 8.2 8 2 abnormal allantois morphology 0.00028861408767461 0.00531798180067106 1.39503347741334 0.521739130434783 8.2 8 2 atrial septal defect 0.00028861408767461 0.00531798180067106 1.39503347741334 0.521739130434783 8.2 8 2 abnormal ovary morphology 7.61171139918988e-06 0.000244311382006256 1.39339611417694 0.52112676056338 8.2 8 2 overriding aortic valve 0.000224812633962568 0.00440331832269203 1.39261154429283 0.520833333333333 8.2 8 2 seminiferous tubule degeneration 5.96213075826233e-06 0.000192607795599708 1.39184846947404 0.520547945205479 8.2 8 2 kyphosis 1.0846912576631e-10 1.10129367487223e-08 1.39038336582196 0.52 8.2 8 2 mandible hypoplasia 0.00739644819415227 0.0659450354227733 1.39038336582196 0.52 8.2 8 2 abnormal primitive streak morphology 0.00739644819415227 0.0659450354227733 1.39038336582196 0.52 8.2 8 2 decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 0.00739644819415227 0.0659450354227733 1.39038336582196 0.52 8.2 8 2 distended pericardium 0.000136598920162037 0.00284342940504659 1.38832658569501 0.519230769230769 8.2 8 2 abnormal placenta vasculature 0.000136598920162037 0.00284342940504659 1.38832658569501 0.519230769230769 8.2 8 2 kinked neural tube 0.000136598920162037 0.00284342940504659 1.38832658569501 0.519230769230769 8.2 8 2 abnormal nervous system morphology 2.86808686955901e-06 0.000100484029408846 1.387675705908 0.518987341772152 8.2 8 2 abnormal neural tube morphology 2.576565826457e-11 2.98102674107525e-09 1.38642215965153 0.518518518518518 8.2 8 2 decreased susceptibility to pharmacologically induced seizures 0.00568355698972367 0.0553582008889733 1.38642215965153 0.518518518518518 8.2 8 2 reduced fertility 6.95585896147989e-10 6.40840709877082e-08 1.38499726534562 0.517985611510791 8.2 8 2 hyperactivity 8.15855890207541e-24 3.12221773367886e-21 1.38375288325636 0.517520215633423 8.2 8 2 reduced female fertility 2.0286605270042e-15 4.03703444873835e-13 1.38300732674598 0.517241379310345 8.2 8 2 increased mortality induced by gamma-irradiation 0.00437510988000516 0.0463110035170759 1.38300732674598 0.517241379310345 8.2 8 2 absent long term depression 0.00437510988000516 0.0463110035170759 1.38300732674598 0.517241379310345 8.2 8 2 anophthalmia 8.49541489088425e-07 3.58489290248157e-05 1.3819713662016 0.51685393258427 8.2 8 2 increased startle reflex 8.49541489088425e-07 3.58489290248157e-05 1.3819713662016 0.51685393258427 8.2 8 2 abnormal postnatal growth/weight/body size 0.00337317354619397 0.0377113222299214 1.38003311744115 0.516129032258065 8.2 8 2 small cranium 0.00337317354619397 0.0377113222299214 1.38003311744115 0.516129032258065 8.2 8 2 preaxial polydactyly 0.00337317354619397 0.0377113222299214 1.38003311744115 0.516129032258065 8.2 8 2 preweaning lethality, incomplete penetrance 8.45426434105978e-26 4.20599650967724e-23 1.37940046167216 0.515892420537897 8.2 8 2 increased sacral vertebrae number 3.09344330024611e-05 0.000822988257685795 1.3786854288499 0.515625 8.2 8 2 increased cardiomyocyte apoptosis 0.00260431649829057 0.0308487489976085 1.37741941835509 0.515151515151515 8.2 8 2 pericardial edema 1.89043926745886e-05 0.000553231491506344 1.37622787906586 0.514705882352941 8.2 8 2 increased circulating serum albumin level 0.00201321654393101 0.0257474352340791 1.37510442773601 0.514285714285714 8.2 8 2 abnormal midbrain development 0.00201321654393101 0.0257474352340791 1.37510442773601 0.514285714285714 8.2 8 2 holoprosencephaly 0.00201321654393101 0.0257474352340791 1.37510442773601 0.514285714285714 8.2 8 2 decreased circulating thyroxine level 0.00201321654393101 0.0257474352340791 1.37510442773601 0.514285714285714 8.2 8 2 hydrops fetalis 1.15650160752877e-05 0.000352981318862307 1.37404339036893 0.513888888888889 8.2 8 2 abnormal vocalization 0.00155802591279135 0.0209491322057756 1.37303970637304 0.513513513513513 8.2 8 2 abnormal breathing pattern 0.00155802591279135 0.0209491322057756 1.37303970637304 0.513513513513513 8.2 8 2 scaly skin 0.000935891848236661 0.0139403052244832 1.36951457233871 0.51219512195122 8.2 8 2 lethality at weaning, incomplete penetrance 0.000935891848236661 0.0139403052244832 1.36951457233871 0.51219512195122 8.2 8 2 abnormal ovarian follicle morphology 0.000564083891739562 0.00935439120468106 1.36661612879936 0.511111111111111 8.2 8 2 cardiomyopathy 0.000564083891739562 0.00935439120468106 1.36661612879936 0.511111111111111 8.2 8 2 embryonic lethality during organogenesis, complete penetrance 1.66276029817708e-33 1.03402906042887e-30 1.36555509143228 0.510714285714286 8.2 8 2 lethality throughout fetal growth and development, complete penetrance 2.58123693809069e-12 3.31271698129532e-10 1.36505249478472 0.510526315789474 8.2 8 2 abnormal embryonic tissue morphology 7.65848759264e-10 6.56913375403173e-08 1.36419090053175 0.510204081632653 8.2 8 2 failure of chorioallantoic fusion 0.00026532433137665 0.00494377733557615 1.36312094688428 0.509803921568627 8.2 8 2 abnormal mesoderm development 0.000206586141847449 0.00407843672893278 1.36213174445548 0.509433962264151 8.2 8 2 abnormal embryo development 4.85038626415731e-09 3.39868614988488e-07 1.35656748079349 0.507352941176471 8.2 8 2 abnormal skeletal muscle fiber morphology 2.21617465372568e-05 0.000626447096720754 1.35573675973972 0.507042253521127 8.2 8 2 pale yolk sac 5.07551429282783e-06 0.000167223070243831 1.35301439676836 0.506024096385542 8.2 8 2 small ovary 1.90831136925571e-06 6.98077136915231e-05 1.35159836914223 0.505494505494505 8.2 8 2 abnormal myocardial fiber morphology 9.17979960319073e-07 3.80579191882283e-05 1.3506896297636 0.505154639175258 8.2 8 2 abnormal embryo size 1.31222091325887e-07 6.70000370103836e-06 1.34873811864962 0.504424778761062 8.2 8 2 embryonic growth arrest 1.10688992256136e-13 1.61964040139493e-11 1.34274510471553 0.502183406113537 8.2 8 2 sparse hair 9.57101379690773e-06 0.000301365782529215 1.33690708252112 0.5 8.2 8 2 small seminiferous tubules 2.55981556249964e-05 0.000707066166616193 1.33690708252112 0.5 8.2 8 2 abnormal somite shape 0.00855306548034344 0.074651755727559 1.33690708252112 0.5 8.2 8 2 increased bone resorption 0.00855306548034344 0.074651755727559 1.33690708252112 0.5 8.2 8 2 abnormal mitotic spindle morphology 0.00855306548034344 0.074651755727559 1.33690708252112 0.5 8.2 8 2 thick skin 0.0111531501899933 0.0935698519312256 1.33690708252112 0.5 8.2 8 2 abnormal erythrocyte osmotic lysis 0.0111531501899933 0.0935698519312256 1.33690708252112 0.5 8.2 8 2 midline facial cleft 0.0585836117862942 0.284900751355634 1.33690708252112 0.5 8.2 8 2 abnormal blood flow velocity 0.0585836117862942 0.284900751355634 1.33690708252112 0.5 8.2 8 2 abnormal kidney blood vessel morphology 0.0585836117862942 0.284900751355634 1.33690708252112 0.5 8.2 8 2 irregularly shaped pupil 0.0585836117862942 0.284900751355634 1.33690708252112 0.5 8.2 8 2 abnormal endplate potential 0.0585836117862942 0.284900751355634 1.33690708252112 0.5 8.2 8 2 decreased coping response 0.0585836117862942 0.284900751355634 1.33690708252112 0.5 8.2 8 2 abnormal ventral body wall morphology 0.0585836117862942 0.284900751355634 1.33690708252112 0.5 8.2 8 2 absent olfactory bulb 0.0585836117862942 0.284900751355634 1.33690708252112 0.5 8.2 8 2 abnormal renal tubule epithelial cell primary cilium morphology 0.0585836117862942 0.284900751355634 1.33690708252112 0.5 8.2 8 2 decreased response to antigen 0.0585836117862942 0.284900751355634 1.33690708252112 0.5 8.2 8 2 decreased total body fat amount 5.9816660394458e-19 1.48793942731214e-16 1.33690708252112 0.5 8.2 8 2 muscular ventricular septal defect 0.000144933771803029 0.0029918901025729 1.33690708252112 0.5 8.2 8 2 cochlear ganglion degeneration 0.000185965493965307 0.0037305577922476 1.33690708252112 0.5 8.2 8 2 abnormal long bone epiphyseal plate proliferative zone 0.00030662445309743 0.00556736005167778 1.33690708252112 0.5 8.2 8 2 abnormal optic nerve morphology 0.00139534614124294 0.0192829084796767 1.33690708252112 0.5 8.2 8 2 incomplete somite formation 0.00232766660976361 0.027836878325899 1.33690708252112 0.5 8.2 8 2 abnormal reproductive system physiology 0.00232766660976361 0.027836878325899 1.33690708252112 0.5 8.2 8 2 impaired branching involved in ureteric bud morphogenesis 0.00232766660976361 0.027836878325899 1.33690708252112 0.5 8.2 8 2 abnormal cell proliferation 0.0251149235248967 0.158427035562119 1.33690708252112 0.5 8.2 8 2 abnormal vascular regression 0.0251149235248967 0.158427035562119 1.33690708252112 0.5 8.2 8 2 small gonad 0.0251149235248967 0.158427035562119 1.33690708252112 0.5 8.2 8 2 increased mammary adenocarcinoma incidence 0.0251149235248967 0.158427035562119 1.33690708252112 0.5 8.2 8 2 abnormal postnatal subventricular zone morphology 0.0251149235248967 0.158427035562119 1.33690708252112 0.5 8.2 8 2 enhanced behavioral response to xenobiotic 0.0251149235248967 0.158427035562119 1.33690708252112 0.5 8.2 8 2 abnormal neuron proliferation 0.0251149235248967 0.158427035562119 1.33690708252112 0.5 8.2 8 2 decreased muscle cell glucose uptake 0.0251149235248967 0.158427035562119 1.33690708252112 0.5 8.2 8 2 retarded hair growth 0.106726880888936 0.390416347369453 1.33690708252112 0.5 8.2 8 2 increased cranium width 0.106726880888936 0.390416347369453 1.33690708252112 0.5 8.2 8 2 rhinitis 0.106726880888936 0.390416347369453 1.33690708252112 0.5 8.2 8 2 abnormal scala media morphology 0.106726880888936 0.390416347369453 1.33690708252112 0.5 8.2 8 2 abnormal pillar cell morphology 0.106726880888936 0.390416347369453 1.33690708252112 0.5 8.2 8 2 abnormal placental transport 0.106726880888936 0.390416347369453 1.33690708252112 0.5 8.2 8 2 abnormal utricular macula morphology 0.106726880888936 0.390416347369453 1.33690708252112 0.5 8.2 8 2 abnormal respiratory conducting tube morphology 0.106726880888936 0.390416347369453 1.33690708252112 0.5 8.2 8 2 abnormal corneal endothelium morphology 0.106726880888936 0.390416347369453 1.33690708252112 0.5 8.2 8 2 ascites 0.106726880888936 0.390416347369453 1.33690708252112 0.5 8.2 8 2 osteosclerosis 0.106726880888936 0.390416347369453 1.33690708252112 0.5 8.2 8 2 protruding tongue 0.106726880888936 0.390416347369453 1.33690708252112 0.5 8.2 8 2 increased serotonin level 0.106726880888936 0.390416347369453 1.33690708252112 0.5 8.2 8 2 increased circulating fructosamine level 0.106726880888936 0.390416347369453 1.33690708252112 0.5 8.2 8 2 acanthocytosis 0.106726880888936 0.390416347369453 1.33690708252112 0.5 8.2 8 2 abnormal left subclavian artery morphology 0.106726880888936 0.390416347369453 1.33690708252112 0.5 8.2 8 2 abnormal inferior vena cava valve morphology 0.106726880888936 0.390416347369453 1.33690708252112 0.5 8.2 8 2 thick aortic valve 0.106726880888936 0.390416347369453 1.33690708252112 0.5 8.2 8 2 sinus bradycardia 0.106726880888936 0.390416347369453 1.33690708252112 0.5 8.2 8 2 decreased trabecular bone connectivity density 0.106726880888936 0.390416347369453 1.33690708252112 0.5 8.2 8 2 abnormal adaptive thermogenesis 0.106726880888936 0.390416347369453 1.33690708252112 0.5 8.2 8 2 increased susceptibility to pharmacologically induced seizures 1.72602561862936e-06 6.45637402457222e-05 1.33690708252112 0.5 8.2 8 2 abnormal circadian rhythm 0.00108188857720798 0.015646499045377 1.33690708252112 0.5 8.2 8 2 abnormal amino acid level 0.00108188857720798 0.015646499045377 1.33690708252112 0.5 8.2 8 2 embryonic lethality, incomplete penetrance 0.00108188857720798 0.015646499045377 1.33690708252112 0.5 8.2 8 2 abnormal trophoblast giant cell morphology 0.00301124320723721 0.0343599425596447 1.33690708252112 0.5 8.2 8 2 abnormal endoderm development 0.00390040717202539 0.0420922465961525 1.33690708252112 0.5 8.2 8 2 scoliosis 0.0050591274196115 0.0511568270580634 1.33690708252112 0.5 8.2 8 2 abnormal long term potentiation 0.0050591274196115 0.0511568270580634 1.33690708252112 0.5 8.2 8 2 abnormal spongiotrophoblast layer morphology 0.0050591274196115 0.0511568270580634 1.33690708252112 0.5 8.2 8 2 pancreatic islet hyperplasia 0.0050591274196115 0.0511568270580634 1.33690708252112 0.5 8.2 8 2 abnormal body weight 0.0145772321127869 0.116407270884615 1.33690708252112 0.5 8.2 8 2 increased stereotypic behavior 0.0145772321127869 0.116407270884615 1.33690708252112 0.5 8.2 8 2 abnormal retinal ganglion layer morphology 0.0145772321127869 0.116407270884615 1.33690708252112 0.5 8.2 8 2 abnormal germ layer development 0.0191037014863771 0.138745861160184 1.33690708252112 0.5 8.2 8 2 abnormal lysosome physiology 0.0191037014863771 0.138745861160184 1.33690708252112 0.5 8.2 8 2 prolonged PR interval 0.0191037014863771 0.138745861160184 1.33690708252112 0.5 8.2 8 2 abnormal megakaryocyte differentiation 0.033142578967585 0.193526209347107 1.33690708252112 0.5 8.2 8 2 abnormal heart shape 0.033142578967585 0.193526209347107 1.33690708252112 0.5 8.2 8 2 delayed kidney development 0.033142578967585 0.193526209347107 1.33690708252112 0.5 8.2 8 2 right pulmonary isomerism 0.033142578967585 0.193526209347107 1.33690708252112 0.5 8.2 8 2 absent spleen 0.033142578967585 0.193526209347107 1.33690708252112 0.5 8.2 8 2 eye inflammation 0.033142578967585 0.193526209347107 1.33690708252112 0.5 8.2 8 2 absent allantois 0.033142578967585 0.193526209347107 1.33690708252112 0.5 8.2 8 2 decreased cellular sensitivity to gamma-irradiation 0.033142578967585 0.193526209347107 1.33690708252112 0.5 8.2 8 2 jerky movement 0.033142578967585 0.193526209347107 1.33690708252112 0.5 8.2 8 2 atrioventricular block 0.033142578967585 0.193526209347107 1.33690708252112 0.5 8.2 8 2 primary atelectasis 0.033142578967585 0.193526209347107 1.33690708252112 0.5 8.2 8 2 absent mandible 0.0439377355864159 0.23303862957614 1.33690708252112 0.5 8.2 8 2 decreased circulating triiodothyronine level 0.0439377355864159 0.23303862957614 1.33690708252112 0.5 8.2 8 2 impaired behavioral response to addictive substance 0.0439377355864159 0.23303862957614 1.33690708252112 0.5 8.2 8 2 abnormal thoracic cage shape 0.0439377355864159 0.23303862957614 1.33690708252112 0.5 8.2 8 2 abnormal superior cervical ganglion morphology 0.0786869554263969 0.31068857400502 1.33690708252112 0.5 8.2 8 2 interstitial pneumonia 0.0786869554263969 0.31068857400502 1.33690708252112 0.5 8.2 8 2 altered tumor susceptibility 0.0786869554263969 0.31068857400502 1.33690708252112 0.5 8.2 8 2 abnormal respiratory function 0.0786869554263969 0.31068857400502 1.33690708252112 0.5 8.2 8 2 absent ovary 0.0786869554263969 0.31068857400502 1.33690708252112 0.5 8.2 8 2 abnormal nucleotide metabolism 0.0786869554263969 0.31068857400502 1.33690708252112 0.5 8.2 8 2 abnormal rostral-caudal body axis extension 0.0786869554263969 0.31068857400502 1.33690708252112 0.5 8.2 8 2 stria vascularis degeneration 0.0786869554263969 0.31068857400502 1.33690708252112 0.5 8.2 8 2 small parietal bone 0.0786869554263969 0.31068857400502 1.33690708252112 0.5 8.2 8 2 hematuria 0.0786869554263969 0.31068857400502 1.33690708252112 0.5 8.2 8 2 abnormal behavioral response to addictive substance 0.0786869554263969 0.31068857400502 1.33690708252112 0.5 8.2 8 2 decreased red blood cell distribution width 0.0786869554263969 0.31068857400502 1.33690708252112 0.5 8.2 8 2 persistent right dorsal aorta 0.0786869554263969 0.31068857400502 1.33690708252112 0.5 8.2 8 2 decreased grip strength 1.00270628878463e-12 1.34823345586583e-10 1.33080248397079 0.497716894977169 8.2 8 2 decreased body length 2.20850719576684e-15 4.2258935765154e-13 1.3271486366633 0.496350364963504 8.2 8 2 hunched posture 2.28169535300709e-05 0.000641323976339564 1.31998420805883 0.493670886075949 8.2 8 2 prenatal lethality, incomplete penetrance 1.5981093277481e-16 3.31274746064449e-14 1.31931619985637 0.493421052631579 8.2 8 2 abnormal fertility/fecundity 4.77762563649508e-05 0.00117666770007738 1.31859328687014 0.493150684931507 8.2 8 2 decreased liver weight 6.11584979590466e-05 0.00143520531767102 1.31807740530251 0.492957746478873 8.2 8 2 ventricular septal defect 3.6150523820499e-08 2.19327873179247e-06 1.31724668424875 0.492647058823529 8.2 8 2 decreased susceptibility to hepatic steatosis 0.000164800254120912 0.00338459644832922 1.31568633517951 0.492063492063492 8.2 8 2 decreased birth body size 5.19298146409837e-07 2.34864388944449e-05 1.31345257230145 0.491228070175439 8.2 8 2 abnormal facial morphology 0.000348119257202316 0.00625232239921128 1.31345257230145 0.491228070175439 8.2 8 2 abnormal brain morphology 2.8747148907311e-09 2.20026255098265e-07 1.31199577042445 0.490683229813665 8.2 8 2 abnormal eye morphology 4.08370319827832e-08 2.4186218346946e-06 1.30805297282642 0.489208633093525 8.2 8 2 increased circulating creatinine level 1.57543838929844e-05 0.000472156987154201 1.30581622013691 0.488372093023256 8.2 8 2 postnatal lethality 2.545277292272e-09 1.97855539516456e-07 1.30469245402663 0.487951807228916 8.2 8 2 abnormal developmental patterning 2.57244173180967e-05 0.000707066166616193 1.30429959270353 0.48780487804878 8.2 8 2 Leydig cell hyperplasia 0.00262546096153509 0.0308843785442089 1.30429959270353 0.48780487804878 8.2 8 2 increased embryonic tissue cell apoptosis 4.20434829053381e-05 0.00106717514007172 1.30262741373852 0.487179487179487 8.2 8 2 increased hepatocyte apoptosis 0.00339231958463541 0.0377556821779892 1.30262741373852 0.487179487179487 8.2 8 2 failure of heart looping 0.00339231958463541 0.0377556821779892 1.30262741373852 0.487179487179487 8.2 8 2 increased erythroid progenitor cell number 0.00438797538092275 0.0463485722294919 1.3007744586692 0.486486486486487 8.2 8 2 increased bone mineral content 1.54252177049627e-06 5.85805023528165e-05 1.30011147474531 0.486238532110092 8.2 8 2 infertility 1.96656687671754e-06 7.08961609541286e-05 1.29942370637567 0.485981308411215 8.2 8 2 ovary cysts 0.0056827538763368 0.0553582008889733 1.29870973730623 0.485714285714286 8.2 8 2 abnormal inhibitory postsynaptic currents 0.000144275179941678 0.00299070425087436 1.29758628597638 0.485294117647059 8.2 8 2 belly spot 0.00736953769850177 0.0659450354227733 1.29639474668714 0.484848484848485 8.2 8 2 hypoglycemia 1.08057774496377e-05 0.000333905234856816 1.29378104760108 0.483870967741935 8.2 8 2 abnormal spermatogenesis 7.53990272575424e-10 6.56913375403173e-08 1.29331228635195 0.483695652173913 8.2 8 2 hypoactivity 1.81510217788732e-18 4.10460606135881e-16 1.29080683829625 0.482758620689655 8.2 8 2 abnormal spinal nerve morphology 0.0124524907073258 0.102229606054366 1.29080683829625 0.482758620689655 8.2 8 2 decreased trophoblast giant cell number 0.0124524907073258 0.102229606054366 1.29080683829625 0.482758620689655 8.2 8 2 polychromatophilia 0.0124524907073258 0.102229606054366 1.29080683829625 0.482758620689655 8.2 8 2 abnormal single cell response 0.0162320581616723 0.126663805599253 1.28739200539071 0.481481481481481 8.2 8 2 thick interventricular septum 0.0162320581616723 0.126663805599253 1.28739200539071 0.481481481481481 8.2 8 2 abnormal somite development 5.98631930580244e-05 0.00141818754982701 1.28613845913424 0.481012658227848 8.2 8 2 abnormal placenta morphology 5.98631930580244e-05 0.00141818754982701 1.28613845913424 0.481012658227848 8.2 8 2 cachexia 4.53716996312116e-06 0.000152516355179242 1.28548757934723 0.480769230769231 8.2 8 2 eyelids open at birth 0.00105802960204539 0.0154360623758822 1.28548757934723 0.480769230769231 8.2 8 2 embryonic lethality before implantation, complete penetrance 5.69735976292623e-07 2.55354638023045e-05 1.28343079922027 0.48 8.2 8 2 spleen hyperplasia 9.78208868989311e-05 0.00214387186045014 1.28343079922027 0.48 8.2 8 2 increased circulating chloride level 0.0013603629814962 0.018851826832712 1.28343079922027 0.48 8.2 8 2 spontaneous skin ulceration 0.0212056480376805 0.14130376353227 1.28343079922027 0.48 8.2 8 2 diaphragmatic hernia 0.0212056480376805 0.14130376353227 1.28343079922027 0.48 8.2 8 2 decreased anxiety-related response 7.25216616930969e-07 3.16487076248383e-05 1.28256126615847 0.479674796747967 8.2 8 2 curly tail 0.00175020953844368 0.0229139275098877 1.2812026207494 0.479166666666667 8.2 8 2 postnatal growth retardation 3.98138227249557e-28 2.20081964507394e-25 1.28011037640094 0.478758169934641 8.2 8 2 anemia 1.19520570812704e-10 1.18922967958641e-08 1.27988260980695 0.478672985781991 8.2 8 2 abnormal spatial learning 1.48849257821187e-08 9.87366743547209e-07 1.27949389492819 0.478527607361963 8.2 8 2 abnormal myelin sheath morphology 0.00225333747518661 0.0276117092094911 1.2787806876289 0.478260869565217 8.2 8 2 embryonic lethality between implantation and placentation, complete penetrance 0.00225333747518661 0.0276117092094911 1.2787806876289 0.478260869565217 8.2 8 2 abnormal pulmonary artery morphology 0.0277740539083911 0.169958078959712 1.2787806876289 0.478260869565217 8.2 8 2 abnormal cranial nerve morphology 0.0277740539083911 0.169958078959712 1.2787806876289 0.478260869565217 8.2 8 2 abnormal nasal cavity morphology 0.0277740539083911 0.169958078959712 1.2787806876289 0.478260869565217 8.2 8 2 increased susceptibility to age related obesity 0.0277740539083911 0.169958078959712 1.2787806876289 0.478260869565217 8.2 8 2 abnormal palatal shelf fusion at midline 0.0277740539083911 0.169958078959712 1.2787806876289 0.478260869565217 8.2 8 2 decreased effector memory CD8-positive, alpha-beta T cell number 0.0277740539083911 0.169958078959712 1.2787806876289 0.478260869565217 8.2 8 2 decreased erythrocyte cell number 3.05545238065468e-08 1.92484109482457e-06 1.27729976037049 0.477707006369427 8.2 8 2 maternal effect 0.000262046842800523 0.00491955865257586 1.27704557136346 0.477611940298507 8.2 8 2 abnormal hepatocyte morphology 3.0891827380397e-06 0.000107473315536696 1.27668604276791 0.477477477477477 8.2 8 2 decreased body size 6.40844153818936e-36 6.37639933049841e-33 1.2765954848134 0.477443609022556 8.2 8 2 omphalocele 0.00290327943021222 0.0333575407974729 1.27613857877016 0.477272727272727 8.2 8 2 lethality, incomplete penetrance 0.00290327943021222 0.0333575407974729 1.27613857877016 0.477272727272727 8.2 8 2 premature death 2.94916144846998e-38 3.66801955153453e-35 1.2732448404963 0.476190476190476 8.2 8 2 abnormal reproductive system morphology 0.00374374716180069 0.0404894394129532 1.2732448404963 0.476190476190476 8.2 8 2 spina bifida 0.00374374716180069 0.0404894394129532 1.2732448404963 0.476190476190476 8.2 8 2 abnormal associative learning 0.0364857653402238 0.209603559546898 1.2732448404963 0.476190476190476 8.2 8 2 abnormal tumor vascularization 0.0364857653402238 0.209603559546898 1.2732448404963 0.476190476190476 8.2 8 2 complete atrioventricular septal defect 0.0364857653402238 0.209603559546898 1.2732448404963 0.476190476190476 8.2 8 2 vascular ring 0.0364857653402238 0.209603559546898 1.2732448404963 0.476190476190476 8.2 8 2 decreased body weight 1.20173812101789e-54 5.97864715206402e-51 1.27211352440216 0.475767366720517 8.2 8 2 male infertility 1.24299056246592e-22 3.86492378016748e-20 1.27046040843955 0.475149105367793 8.2 8 2 decreased leukocyte cell number 3.36177220404524e-07 1.60815545337741e-05 1.26859796151639 0.474452554744526 8.2 8 2 absent gastric milk in neonates 0.000107622031326325 0.00234752031262804 1.26834774495593 0.474358974358974 8.2 8 2 incomplete embryo turning 0.000904820759636476 0.0136823199975425 1.26654355186211 0.473684210526316 8.2 8 2 increased bone marrow cell number 0.00624225327496599 0.0582649344145512 1.26654355186211 0.473684210526316 8.2 8 2 decreased hair follicle number 0.00624225327496599 0.0582649344145512 1.26654355186211 0.473684210526316 8.2 8 2 persistence of hyaloid vascular system 0.00624225327496599 0.0582649344145512 1.26654355186211 0.473684210526316 8.2 8 2 hyporesponsive to tactile stimuli 0.00624225327496599 0.0582649344145512 1.26654355186211 0.473684210526316 8.2 8 2 kyphoscoliosis 0.0480996781589094 0.252955495603144 1.26654355186211 0.473684210526316 8.2 8 2 stereotypic behavior 0.0480996781589094 0.252955495603144 1.26654355186211 0.473684210526316 8.2 8 2 maternal imprinting 0.0480996781589094 0.252955495603144 1.26654355186211 0.473684210526316 8.2 8 2 absent amnion 0.0480996781589094 0.252955495603144 1.26654355186211 0.473684210526316 8.2 8 2 Leydig cell hypoplasia 0.0480996781589094 0.252955495603144 1.26654355186211 0.473684210526316 8.2 8 2 embryonic lethality between implantation and somite formation, incomplete penetrance 0.0480996781589094 0.252955495603144 1.26654355186211 0.473684210526316 8.2 8 2 pale liver 0.000175624143857284 0.003580861129877 1.26464183481727 0.472972972972973 8.2 8 2 abnormal rostral-caudal axis patterning 0.00116071960248789 0.0166414409866779 1.26398487801997 0.472727272727273 8.2 8 2 increased grip strength 3.48121919582588e-05 0.000902034661418424 1.26345064941556 0.472527472527473 8.2 8 2 abnormal neuromuscular synapse morphology 0.000224423840791389 0.00440331832269203 1.2626344668255 0.472222222222222 8.2 8 2 increased circulating bilirubin level 0.00148968974046876 0.0202394509642883 1.26123309671804 0.471698113207547 8.2 8 2 domed cranium 0.000286850584208788 0.00531798180067106 1.26051239209134 0.471428571428571 8.2 8 2 abnormal lung development 7.21457704596094e-05 0.00164644590842457 1.25826548943164 0.470588235294118 8.2 8 2 abnormal extraembryonic tissue morphology 1.4423490679156e-05 0.000434890097750309 1.25826548943164 0.470588235294118 8.2 8 2 small lung 0.00191285583992005 0.0248054607862303 1.25826548943164 0.470588235294118 8.2 8 2 abnormal oocyte morphology 0.010453209277592 0.0890491715000342 1.25826548943164 0.470588235294118 8.2 8 2 abnormal interatrial septum morphology 0.0636803951140458 0.291371581809916 1.25826548943164 0.470588235294118 8.2 8 2 increased aggression towards mice 0.0636803951140458 0.291371581809916 1.25826548943164 0.470588235294118 8.2 8 2 hyperlipidemia 0.0636803951140458 0.291371581809916 1.25826548943164 0.470588235294118 8.2 8 2 abnormal touch/ nociception 0.0636803951140458 0.291371581809916 1.25826548943164 0.470588235294118 8.2 8 2 abnormal ectoplacental cone morphology 0.0636803951140458 0.291371581809916 1.25826548943164 0.470588235294118 8.2 8 2 decreased growth hormone level 0.0636803951140458 0.291371581809916 1.25826548943164 0.470588235294118 8.2 8 2 pancytopenia 0.0636803951140458 0.291371581809916 1.25826548943164 0.470588235294118 8.2 8 2 abnormal electroretinogram waveform feature 0.0636803951140458 0.291371581809916 1.25826548943164 0.470588235294118 8.2 8 2 decreased double-positive T cell number 1.83607880606919e-05 0.000545519993287478 1.25669265756985 0.47 8.2 8 2 abnormal vitelline vasculature morphology 4.71191809099527e-06 0.000156278616684676 1.25553012967201 0.469565217391304 8.2 8 2 neonatal lethality, incomplete penetrance 8.12574764712302e-12 1.01063986361092e-09 1.25463587744289 0.469230769230769 8.2 8 2 increased circulating alkaline phosphatase level 6.47439639077408e-08 3.57890244934456e-06 1.25438195397043 0.469135802469136 8.2 8 2 decreased heart weight 0.000117349434310069 0.00253831928561997 1.25438195397043 0.469135802469136 8.2 8 2 decreased circulating LDL cholesterol level 0.000599904447428099 0.00988253187402249 1.25335038986355 0.46875 8.2 8 2 abnormal lumbar vertebrae morphology 0.0135529364197362 0.1094575628055 1.25335038986355 0.46875 8.2 8 2 abnormal serotonin level 0.0135529364197362 0.1094575628055 1.25335038986355 0.46875 8.2 8 2 abnormal eating behavior 0.000982461314202169 0.0145487870457319 1.24777994368638 0.466666666666667 8.2 8 2 trabecula carnea hypoplasia 0.00406361641810105 0.0433247627831472 1.24777994368638 0.466666666666667 8.2 8 2 abnormal heart tube morphology 0.0175976655244042 0.132649069672592 1.24777994368638 0.466666666666667 8.2 8 2 abnormal optic cup morphology 0.0175976655244042 0.132649069672592 1.24777994368638 0.466666666666667 8.2 8 2 decreased hepatocyte number 0.0847480402179718 0.330683529477969 1.24777994368638 0.466666666666667 8.2 8 2 greasy coat 0.0847480402179718 0.330683529477969 1.24777994368638 0.466666666666667 8.2 8 2 abnormal energy homeostasis 0.0847480402179718 0.330683529477969 1.24777994368638 0.466666666666667 8.2 8 2 abnormal cerebral aqueduct morphology 0.0847480402179718 0.330683529477969 1.24777994368638 0.466666666666667 8.2 8 2 abnormal Muller cell morphology 0.0847480402179718 0.330683529477969 1.24777994368638 0.466666666666667 8.2 8 2 absent chorion 0.0847480402179718 0.330683529477969 1.24777994368638 0.466666666666667 8.2 8 2 abnormal coronary vessel morphology 0.0847480402179718 0.330683529477969 1.24777994368638 0.466666666666667 8.2 8 2 cleft palate 1.67510780859591e-06 6.3133798089126e-05 1.24505850433264 0.465648854961832 8.2 8 2 abnormal male reproductive system morphology 0.00523050186739321 0.052675600790043 1.24363449536848 0.465116279069767 8.2 8 2 abnormal eye development 0.00161103921641455 0.0215454841442537 1.2414137194839 0.464285714285714 8.2 8 2 prolonged QRS complex duration 0.0228871851521573 0.147110783116257 1.2414137194839 0.464285714285714 8.2 8 2 liver fibrosis 0.00673733196789422 0.0620446834031038 1.23908461306835 0.463414634146341 8.2 8 2 abnormal chondrocyte morphology 0.00206409722738539 0.0261961319036794 1.23787692826029 0.462962962962963 8.2 8 2 decreased tumor growth/size 0.00206409722738539 0.0261961319036794 1.23787692826029 0.462962962962963 8.2 8 2 abnormal cell adhesion 0.00206409722738539 0.0261961319036794 1.23787692826029 0.462962962962963 8.2 8 2 abnormal cranium morphology 1.80701334192997e-06 6.65917879711231e-05 1.23713789725835 0.462686567164179 8.2 8 2 lethargy 6.62524826790073e-05 0.00154744648510827 1.2362796677077 0.462365591397849 8.2 8 2 abnormal retina morphology 2.97277019946993e-09 2.24083814278226e-07 1.23504749528141 0.461904761904762 8.2 8 2 abnormal nasal bone morphology 0.0298220747642694 0.178684867687274 1.23406807617334 0.461538461538462 8.2 8 2 abnormal nerve conduction 0.0298220747642694 0.178684867687274 1.23406807617334 0.461538461538462 8.2 8 2 absent common myeloid progenitor cells 0.113524212945387 0.407197519396755 1.23406807617334 0.461538461538462 8.2 8 2 absent myocardial trabeculae 0.113524212945387 0.407197519396755 1.23406807617334 0.461538461538462 8.2 8 2 absent trabeculae carneae 0.113524212945387 0.407197519396755 1.23406807617334 0.461538461538462 8.2 8 2 short hair 0.113524212945387 0.407197519396755 1.23406807617334 0.461538461538462 8.2 8 2 small trigeminal ganglion 0.113524212945387 0.407197519396755 1.23406807617334 0.461538461538462 8.2 8 2 dystrophic cardiac calcinosis 0.113524212945387 0.407197519396755 1.23406807617334 0.461538461538462 8.2 8 2 anal atresia 0.113524212945387 0.407197519396755 1.23406807617334 0.461538461538462 8.2 8 2 abnormal telomere length 0.113524212945387 0.407197519396755 1.23406807617334 0.461538461538462 8.2 8 2 abnormal dopaminergic neuron morphology 0.113524212945387 0.407197519396755 1.23406807617334 0.461538461538462 8.2 8 2 abnormal afterhyperpolarization 0.113524212945387 0.407197519396755 1.23406807617334 0.461538461538462 8.2 8 2 abnormal insulin secretion 0.113524212945387 0.407197519396755 1.23406807617334 0.461538461538462 8.2 8 2 small pituitary gland 0.113524212945387 0.407197519396755 1.23406807617334 0.461538461538462 8.2 8 2 orthokeratosis 0.113524212945387 0.407197519396755 1.23406807617334 0.461538461538462 8.2 8 2 empty decidua capsularis 0.113524212945387 0.407197519396755 1.23406807617334 0.461538461538462 8.2 8 2 increased prostaglandin level 0.113524212945387 0.407197519396755 1.23406807617334 0.461538461538462 8.2 8 2 abnormal hair follicle inner root sheath morphology 0.113524212945387 0.407197519396755 1.23406807617334 0.461538461538462 8.2 8 2 decreased cardiac stroke volume 0.113524212945387 0.407197519396755 1.23406807617334 0.461538461538462 8.2 8 2 perinatal lethality, incomplete penetrance 1.05942627363316e-09 8.50104146987899e-08 1.23042775736457 0.460176991150442 8.2 8 2 perinatal lethality, complete penetrance 3.19259340438155e-09 2.36460126289608e-07 1.23020557828234 0.460093896713615 8.2 8 2 increased monocyte cell number 4.40037103064807e-05 0.00109650016461801 1.22995451591943 0.46 8.2 8 2 abnormal intestine morphology 0.000426106232665465 0.00738633626310344 1.22850921096535 0.459459459459459 8.2 8 2 abnormal respiratory electron transport chain 0.0112053687839219 0.093849679629649 1.22850921096535 0.459459459459459 8.2 8 2 edema 1.11212862233467e-07 5.82404199591052e-06 1.22808906417638 0.459302325581395 8.2 8 2 polydactyly 5.58918795678136e-05 0.00134329517318779 1.22777181047858 0.459183673469388 8.2 8 2 abnormal seminiferous tubule morphology 1.02296411697435e-06 4.10423103382854e-05 1.22702430861527 0.458904109589041 8.2 8 2 abnormal foregut morphology 0.0389405954277485 0.212458872349148 1.22549815897769 0.458333333333333 8.2 8 2 decreased metastatic potential 0.0389405954277485 0.212458872349148 1.22549815897769 0.458333333333333 8.2 8 2 abnormal sensory capabilities/reflexes/nociception 0.0389405954277485 0.212458872349148 1.22549815897769 0.458333333333333 8.2 8 2 abnormal tumor morphology 0.0389405954277485 0.212458872349148 1.22549815897769 0.458333333333333 8.2 8 2 hypopigmentation 0.0389405954277485 0.212458872349148 1.22549815897769 0.458333333333333 8.2 8 2 lethality throughout fetal growth and development, incomplete penetrance 7.43875584552916e-08 4.02258807951169e-06 1.22487576275678 0.458100558659218 8.2 8 2 thymus hypoplasia 2.62692203103712e-06 9.33495507457832e-05 1.22065429273667 0.456521739130435 8.2 8 2 increased macrophage cell number 0.00220335147048648 0.0271328553605699 1.21963453142277 0.456140350877193 8.2 8 2 decreased mean corpuscular hemoglobin 0.00088214348022166 0.013420990257195 1.2189446928869 0.455882352941176 8.2 8 2 abnormal heart development 5.75743438421047e-07 2.55743179120063e-05 1.21844696128507 0.455696202531646 8.2 8 2 increased mean corpuscular hemoglobin 7.56284741464782e-05 0.00170724114608468 1.2153700750192 0.454545454545455 8.2 8 2 single kidney 0.0187057686874316 0.137293299418972 1.2153700750192 0.454545454545455 8.2 8 2 abnormal QRS complex 0.0187057686874316 0.137293299418972 1.2153700750192 0.454545454545455 8.2 8 2 abnormal suckling behavior 0.000184706622560902 0.0037305577922476 1.2153700750192 0.454545454545455 8.2 8 2 abnormal myelopoiesis 0.00716985389837734 0.0643863233653922 1.2153700750192 0.454545454545455 8.2 8 2 abnormal retinal layer morphology 0.0509708185517626 0.256141234641433 1.2153700750192 0.454545454545455 8.2 8 2 abnormal basement membrane morphology 0.0509708185517626 0.256141234641433 1.2153700750192 0.454545454545455 8.2 8 2 abnormal sperm midpiece morphology 0.0509708185517626 0.256141234641433 1.2153700750192 0.454545454545455 8.2 8 2 pulmonary vascular congestion 0.0509708185517626 0.256141234641433 1.2153700750192 0.454545454545455 8.2 8 2 increased adenoma incidence 0.0509708185517626 0.256141234641433 1.2153700750192 0.454545454545455 8.2 8 2 premature suture closure 0.15335925234271 0.488430505411996 1.2153700750192 0.454545454545455 8.2 8 2 abnormal thrombopoiesis 0.15335925234271 0.488430505411996 1.2153700750192 0.454545454545455 8.2 8 2 abnormal stomach epithelium morphology 0.15335925234271 0.488430505411996 1.2153700750192 0.454545454545455 8.2 8 2 delayed hepatic development 0.15335925234271 0.488430505411996 1.2153700750192 0.454545454545455 8.2 8 2 abnormal glossopharyngeal ganglion morphology 0.15335925234271 0.488430505411996 1.2153700750192 0.454545454545455 8.2 8 2 failure of somite differentiation 0.15335925234271 0.488430505411996 1.2153700750192 0.454545454545455 8.2 8 2 abnormal vestibular ganglion morphology 0.15335925234271 0.488430505411996 1.2153700750192 0.454545454545455 8.2 8 2 patent ductus arteriosus 0.15335925234271 0.488430505411996 1.2153700750192 0.454545454545455 8.2 8 2 fused joints 0.15335925234271 0.488430505411996 1.2153700750192 0.454545454545455 8.2 8 2 abnormal pituitary gland development 0.15335925234271 0.488430505411996 1.2153700750192 0.454545454545455 8.2 8 2 abnormal coronal suture morphology 0.15335925234271 0.488430505411996 1.2153700750192 0.454545454545455 8.2 8 2 abnormal crista ampullaris neuroepithelium morphology 0.15335925234271 0.488430505411996 1.2153700750192 0.454545454545455 8.2 8 2 cyclopia 0.15335925234271 0.488430505411996 1.2153700750192 0.454545454545455 8.2 8 2 increased glycogen level 0.15335925234271 0.488430505411996 1.2153700750192 0.454545454545455 8.2 8 2 increased circulating triiodothyronine level 0.15335925234271 0.488430505411996 1.2153700750192 0.454545454545455 8.2 8 2 abnormal palatal shelf elevation 0.15335925234271 0.488430505411996 1.2153700750192 0.454545454545455 8.2 8 2 aberrant origin of the right subclavian artery 0.15335925234271 0.488430505411996 1.2153700750192 0.454545454545455 8.2 8 2 abnormal extraembryonic ectoderm morphology 0.15335925234271 0.488430505411996 1.2153700750192 0.454545454545455 8.2 8 2 abnormal brain ependyma motile cilium morphology 0.15335925234271 0.488430505411996 1.2153700750192 0.454545454545455 8.2 8 2 hypolactation 0.15335925234271 0.488430505411996 1.2153700750192 0.454545454545455 8.2 8 2 reduced sympathetic cervical ganglion size 0.15335925234271 0.488430505411996 1.2153700750192 0.454545454545455 8.2 8 2 postnatal lethality, incomplete penetrance 6.36639068728622e-21 1.75959964829161e-18 1.21451418060017 0.454225352112676 8.2 8 2 reduced male fertility 3.27954748019757e-09 2.36460126289608e-07 1.21322845374163 0.45374449339207 8.2 8 2 increased or absent threshold for auditory brainstem response 2.84861869727444e-11 3.22088136794098e-09 1.21200572879077 0.453287197231834 8.2 8 2 decreased caudal vertebrae number 0.00143354275391278 0.0197013127091605 1.21157204353476 0.453125 8.2 8 2 abnormal cranial ganglia morphology 0.0242074789966789 0.154598469844002 1.20752897776101 0.451612903225806 8.2 8 2 abnormal capillary morphology 0.0242074789966789 0.154598469844002 1.20752897776101 0.451612903225806 8.2 8 2 abnormal retinal photoreceptor layer morphology 0.0242074789966789 0.154598469844002 1.20752897776101 0.451612903225806 8.2 8 2 abnormal mitochondrial ATP synthesis coupled electron transport 0.0242074789966789 0.154598469844002 1.20752897776101 0.451612903225806 8.2 8 2 increased spleen weight 3.29907097889018e-05 0.00086840624973432 1.20676568510756 0.451327433628319 8.2 8 2 abnormal bone structure 7.5296854676659e-08 4.02797690340192e-06 1.20529446817966 0.450777202072539 8.2 8 2 increased circulating free fatty acid level 0.000934208884544858 0.0139403052244832 1.20509934199087 0.450704225352113 8.2 8 2 respiratory failure 1.96625425309812e-06 7.08961609541286e-05 1.20410174319783 0.450331125827815 8.2 8 2 abnormal dopamine level 0.066905386495829 0.29580563413186 1.20321637426901 0.45 8.2 8 2 absent placental labyrinth 0.066905386495829 0.29580563413186 1.20321637426901 0.45 8.2 8 2 abnormal heart right ventricle morphology 0.066905386495829 0.29580563413186 1.20321637426901 0.45 8.2 8 2 decreased rib number 0.000247999256683151 0.00470914619083465 1.20171423147966 0.449438202247191 8.2 8 2 increased sarcoma incidence 0.0058944698647967 0.0562901210520776 1.20048799246794 0.448979591836735 8.2 8 2 abnormal craniofacial development 0.0058944698647967 0.0562901210520776 1.20048799246794 0.448979591836735 8.2 8 2 increased rib number 0.000609731932509548 0.00994562742372132 1.19978840739075 0.448717948717949 8.2 8 2 abnormal cornea morphology 0.000609731932509548 0.00994562742372132 1.19978840739075 0.448717948717949 8.2 8 2 abnormal heart ventricle morphology 0.000609731932509548 0.00994562742372132 1.19978840739075 0.448717948717949 8.2 8 2 thrombocytosis 0.00297155151474979 0.0340632921333645 1.19860634984652 0.448275862068966 8.2 8 2 abnormal microglial cell morphology 0.0313653743885828 0.185986576380453 1.19860634984652 0.448275862068966 8.2 8 2 focal hair loss 0.0313653743885828 0.185986576380453 1.19860634984652 0.448275862068966 8.2 8 2 decreased retinal photoreceptor cell number 0.0313653743885828 0.185986576380453 1.19860634984652 0.448275862068966 8.2 8 2 aphagia 0.0313653743885828 0.185986576380453 1.19860634984652 0.448275862068966 8.2 8 2 enlarged epididymis 0.0313653743885828 0.185986576380453 1.19860634984652 0.448275862068966 8.2 8 2 blood in lymph vessels 0.0313653743885828 0.185986576380453 1.19860634984652 0.448275862068966 8.2 8 2 increased retinal apoptosis 0.0313653743885828 0.185986576380453 1.19860634984652 0.448275862068966 8.2 8 2 postnatal lethality, complete penetrance 7.27523576620808e-14 1.09679690717834e-11 1.19836748847748 0.448186528497409 8.2 8 2 pulmonary hypoplasia 0.00754297193804298 0.0671311008797206 1.19468292480611 0.446808510638298 8.2 8 2 abnormal coat/hair pigmentation 5.5611794105595e-05 0.00134305182366668 1.19366703796528 0.446428571428571 8.2 8 2 kidney cysts 0.000982591446706716 0.0145487870457319 1.19237658711343 0.445945945945946 8.2 8 2 decreased circulating HDL cholesterol level 1.91200004438046e-05 0.000556269018759811 1.19068287037037 0.4453125 8.2 8 2 diluted coat color 0.00483259163159078 0.0499836660440003 1.18836185112988 0.444444444444444 8.2 8 2 abnormal maxilla morphology 0.00483259163159078 0.0499836660440003 1.18836185112988 0.444444444444444 8.2 8 2 irregular heartbeat 0.0096548438825984 0.08382696041174 1.18836185112988 0.444444444444444 8.2 8 2 abnormal cell migration 0.0096548438825984 0.08382696041174 1.18836185112988 0.444444444444444 8.2 8 2 abnormal trigeminal ganglion morphology 0.040694088046347 0.221260205497898 1.18836185112988 0.444444444444444 8.2 8 2 skin lesions 0.00244519144251433 0.0290330010179207 1.18836185112988 0.444444444444444 8.2 8 2 abnormal reflex 0.0195883404647221 0.140096023255472 1.18836185112988 0.444444444444444 8.2 8 2 lowered ear position 0.0881106480312143 0.33980656895759 1.18836185112988 0.444444444444444 8.2 8 2 underdeveloped hair follicles 0.0881106480312143 0.33980656895759 1.18836185112988 0.444444444444444 8.2 8 2 abnormal radius morphology 0.0881106480312143 0.33980656895759 1.18836185112988 0.444444444444444 8.2 8 2 abnormal mammary gland morphology 0.0881106480312143 0.33980656895759 1.18836185112988 0.444444444444444 8.2 8 2 abnormal phrenic nerve morphology 0.0881106480312143 0.33980656895759 1.18836185112988 0.444444444444444 8.2 8 2 abnormal bile duct morphology 0.0881106480312143 0.33980656895759 1.18836185112988 0.444444444444444 8.2 8 2 acidosis 0.0881106480312143 0.33980656895759 1.18836185112988 0.444444444444444 8.2 8 2 abnormal body wall morphology 0.0881106480312143 0.33980656895759 1.18836185112988 0.444444444444444 8.2 8 2 absent ureter 0.0881106480312143 0.33980656895759 1.18836185112988 0.444444444444444 8.2 8 2 absent inner cell mass 0.0881106480312143 0.33980656895759 1.18836185112988 0.444444444444444 8.2 8 2 decreased tumor latency 0.0881106480312143 0.33980656895759 1.18836185112988 0.444444444444444 8.2 8 2 increased adipocyte glucose uptake 0.0881106480312143 0.33980656895759 1.18836185112988 0.444444444444444 8.2 8 2 increased double-negative T cell number 0.00310975743058336 0.0354028448905085 1.18349151567443 0.442622950819672 8.2 8 2 prenatal lethality, complete penetrance 7.34235271199801e-10 6.56913375403173e-08 1.18301849748272 0.442446043165468 8.2 8 2 decreased circulating alanine transaminase level 0.00200836729301472 0.0257474352340791 1.17962389634216 0.441176470588235 8.2 8 2 thin skin 0.025220947168884 0.158427035562119 1.17962389634216 0.441176470588235 8.2 8 2 abnormal vision 0.025220947168884 0.158427035562119 1.17962389634216 0.441176470588235 8.2 8 2 abnormal bone remodeling 0.025220947168884 0.158427035562119 1.17962389634216 0.441176470588235 8.2 8 2 increased susceptibility to weight gain 0.025220947168884 0.158427035562119 1.17962389634216 0.441176470588235 8.2 8 2 decreased circulating glucose level 9.62773920526197e-10 7.85213156494726e-08 1.17877828781432 0.440860215053763 8.2 8 2 azoospermia 3.78581010260924e-06 0.000129892450072283 1.17715089027017 0.440251572327044 8.2 8 2 increased cellular sensitivity to ionizing radiation 0.0528751969485162 0.2638456417441 1.17647823261858 0.44 8.2 8 2 abnormal preimplantation embryo development 0.0528751969485162 0.2638456417441 1.17647823261858 0.44 8.2 8 2 increased liver glycogen level 0.0528751969485162 0.2638456417441 1.17647823261858 0.44 8.2 8 2 embryonic lethality during organogenesis, incomplete penetrance 3.68216614610002e-08 2.20708151528285e-06 1.17415317682289 0.439130434782609 8.2 8 2 abnormal mammary gland development 0.0158292753070419 0.12421237326898 1.17386963343318 0.439024390243902 8.2 8 2 decreased percent body fat/body weight 0.00164733314996422 0.0219130546017967 1.17208292166235 0.438356164383562 8.2 8 2 hemorrhage 3.05653158776163e-08 1.92484109482457e-06 1.1719270595717 0.438297872340426 8.2 8 2 abnormal neuron differentiation 0.000121701614716843 0.00262106291435625 1.16979369720598 0.4375 8.2 8 2 abnormal hair follicle orientation 0.116489388264738 0.410357098997245 1.16979369720598 0.4375 8.2 8 2 disorganized yolk sac vascular plexus 0.116489388264738 0.410357098997245 1.16979369720598 0.4375 8.2 8 2 abnormal extraembryonic endoderm formation 0.116489388264738 0.410357098997245 1.16979369720598 0.4375 8.2 8 2 abnormal meiosis 0.116489388264738 0.410357098997245 1.16979369720598 0.4375 8.2 8 2 increased intestinal adenocarcinoma incidence 0.116489388264738 0.410357098997245 1.16979369720598 0.4375 8.2 8 2 increased pancreatic beta cell number 0.116489388264738 0.410357098997245 1.16979369720598 0.4375 8.2 8 2 small pancreas 0.116489388264738 0.410357098997245 1.16979369720598 0.4375 8.2 8 2 small epididymis 0.116489388264738 0.410357098997245 1.16979369720598 0.4375 8.2 8 2 abnormal level of surface class II molecules 0.116489388264738 0.410357098997245 1.16979369720598 0.4375 8.2 8 2 loose skin 0.116489388264738 0.410357098997245 1.16979369720598 0.4375 8.2 8 2 decreased liver cholesterol level 0.116489388264738 0.410357098997245 1.16979369720598 0.4375 8.2 8 2 decreased fibroblast apoptosis 0.116489388264738 0.410357098997245 1.16979369720598 0.4375 8.2 8 2 decreased circulating cholesterol level 1.13309527398783e-06 4.47392776832496e-05 1.16888050930808 0.437158469945355 8.2 8 2 increased circulating alanine transaminase level 0.00134982587537448 0.018851826832712 1.16550873860815 0.435897435897436 8.2 8 2 impaired glucose tolerance 2.18111213220303e-08 1.42776748127764e-06 1.16440294284097 0.435483870967742 8.2 8 2 abnormal testis morphology 0.000126147581183807 0.0026819838307241 1.16252789784445 0.434782608695652 8.2 8 2 hydroencephaly 0.000126147581183807 0.0026819838307241 1.16252789784445 0.434782608695652 8.2 8 2 hyperkeratosis 0.00263917627206114 0.0308938869494216 1.16252789784445 0.434782608695652 8.2 8 2 failure of embryo implantation 0.0688144836620483 0.29580563413186 1.16252789784445 0.434782608695652 8.2 8 2 conjunctivitis 0.0688144836620483 0.29580563413186 1.16252789784445 0.434782608695652 8.2 8 2 abnormal lens development 0.0688144836620483 0.29580563413186 1.16252789784445 0.434782608695652 8.2 8 2 abnormal basicranium morphology 0.0688144836620483 0.29580563413186 1.16252789784445 0.434782608695652 8.2 8 2 abnormal blood vessel morphology 1.86422099990868e-05 0.000548786951156549 1.16172615446663 0.43448275862069 8.2 8 2 weight loss 2.79752015239824e-06 9.87068280722073e-05 1.16119929453263 0.434285714285714 8.2 8 2 extramedullary hematopoiesis 0.000242497708917619 0.00462232222936842 1.16033444898059 0.433962264150943 8.2 8 2 abnormal placenta development 0.00812677235790622 0.0713063359445916 1.16033444898059 0.433962264150943 8.2 8 2 increased insulin sensitivity 2.33820261612779e-05 0.000653514495237964 1.15927607155677 0.433566433566434 8.2 8 2 decreased insulin secretion 0.000718042192975798 0.0114495509937647 1.15865280485164 0.433333333333333 8.2 8 2 abnormal kidney development 0.00519668244133365 0.0524411666240059 1.15865280485164 0.433333333333333 8.2 8 2 decreased cardiac muscle contractility 0.000304936421463038 0.00555699156329163 1.15693882141251 0.432692307692308 8.2 8 2 abnormal branching of the mammary ductal tree 0.0259753665072366 0.162754972762597 1.15624396326151 0.432432432432432 8.2 8 2 decreased circulating chloride level 0.0259753665072366 0.162754972762597 1.15624396326151 0.432432432432432 8.2 8 2 muscular atrophy 0.0163062034008634 0.126663805599253 1.15460157126824 0.431818181818182 8.2 8 2 cochlear inner hair cell degeneration 0.0103284884804776 0.0881376161069911 1.153410031979 0.431372549019608 8.2 8 2 abnormal trophoblast layer morphology 0.0103284884804776 0.0881376161069911 1.153410031979 0.431372549019608 8.2 8 2 small testis 8.71955202417355e-09 5.94243442743335e-07 1.15284016536241 0.431159420289855 8.2 8 2 enlarged heart 1.30360307794852e-07 6.70000370103836e-06 1.15250610562165 0.431034482758621 8.2 8 2 abnormal liver morphology 3.7305602934737e-06 0.000128885676805775 1.15018821624722 0.430167597765363 8.2 8 2 abnormal definitive hematopoiesis 0.000739752221335319 0.0117580424956652 1.15002759786763 0.43010752688172 8.2 8 2 increased T cell proliferation 0.000314135467744947 0.00566240562330112 1.14949020179386 0.429906542056075 8.2 8 2 spleen hypoplasia 0.00039421868519707 0.00690576746075853 1.14592035644667 0.428571428571429 8.2 8 2 female infertility 2.63709731935018e-08 1.70383885243729e-06 1.14592035644667 0.428571428571429 8.2 8 2 increased thermal nociceptive threshold 0.000929955202878404 0.0139403052244832 1.14592035644667 0.428571428571429 8.2 8 2 arrest of spermatogenesis 0.0014329672290658 0.0197013127091605 1.14592035644667 0.428571428571429 8.2 8 2 impaired fertilization 0.00343149275251504 0.0380215510996934 1.14592035644667 0.428571428571429 8.2 8 2 increased circulating LDL cholesterol level 0.0131234837190299 0.10703169098717 1.14592035644667 0.428571428571429 8.2 8 2 thick pulmonary interalveolar septum 0.0332838313865603 0.193669077366243 1.14592035644667 0.428571428571429 8.2 8 2 impaired adaptive thermogenesis 0.0332838313865603 0.193669077366243 1.14592035644667 0.428571428571429 8.2 8 2 small superior cervical ganglion 0.0540492652169894 0.267823799257492 1.14592035644667 0.428571428571429 8.2 8 2 abnormal retinal inner nuclear layer morphology 0.0540492652169894 0.267823799257492 1.14592035644667 0.428571428571429 8.2 8 2 abnormal hormone level 0.0540492652169894 0.267823799257492 1.14592035644667 0.428571428571429 8.2 8 2 decreased circulating progesterone level 0.0540492652169894 0.267823799257492 1.14592035644667 0.428571428571429 8.2 8 2 corneal vascularization 0.0540492652169894 0.267823799257492 1.14592035644667 0.428571428571429 8.2 8 2 abnormal scapula morphology 0.0897201023625328 0.342519395251742 1.14592035644667 0.428571428571429 8.2 8 2 abnormal salivary gland morphology 0.0897201023625328 0.342519395251742 1.14592035644667 0.428571428571429 8.2 8 2 increased incidence of induced tumors 0.0897201023625328 0.342519395251742 1.14592035644667 0.428571428571429 8.2 8 2 liver degeneration 0.0897201023625328 0.342519395251742 1.14592035644667 0.428571428571429 8.2 8 2 increased keratinocyte proliferation 0.0897201023625328 0.342519395251742 1.14592035644667 0.428571428571429 8.2 8 2 absent segment of posterior cerebral artery 0.0897201023625328 0.342519395251742 1.14592035644667 0.428571428571429 8.2 8 2 decreased vocalization 0.0897201023625328 0.342519395251742 1.14592035644667 0.428571428571429 8.2 8 2 abnormal adrenal gland secretion 0.154729663814706 0.488430505411996 1.14592035644667 0.428571428571429 8.2 8 2 abnormal imprinting 0.154729663814706 0.488430505411996 1.14592035644667 0.428571428571429 8.2 8 2 enlarged stomach 0.154729663814706 0.488430505411996 1.14592035644667 0.428571428571429 8.2 8 2 abnormal pancreas development 0.154729663814706 0.488430505411996 1.14592035644667 0.428571428571429 8.2 8 2 abnormal maternal decidual layer morphology 0.154729663814706 0.488430505411996 1.14592035644667 0.428571428571429 8.2 8 2 decreased CNS synapse formation 0.154729663814706 0.488430505411996 1.14592035644667 0.428571428571429 8.2 8 2 premature hair loss 0.154729663814706 0.488430505411996 1.14592035644667 0.428571428571429 8.2 8 2 decreased cornea thickness 0.154729663814706 0.488430505411996 1.14592035644667 0.428571428571429 8.2 8 2 decreased tongue size 0.154729663814706 0.488430505411996 1.14592035644667 0.428571428571429 8.2 8 2 sternebra fusion 0.154729663814706 0.488430505411996 1.14592035644667 0.428571428571429 8.2 8 2 abnormal renal reabsorbtion 0.154729663814706 0.488430505411996 1.14592035644667 0.428571428571429 8.2 8 2 pulmonary alveolar hemorrhage 0.154729663814706 0.488430505411996 1.14592035644667 0.428571428571429 8.2 8 2 multiple persisting craniopharyngeal ducts 0.154729663814706 0.488430505411996 1.14592035644667 0.428571428571429 8.2 8 2 decreased bone mineral content 9.062309610024e-07 3.78865464788818e-05 1.14408394561903 0.427884615384615 8.2 8 2 thrombocytopenia 3.88893781507589e-05 0.000992177724615515 1.14328605677668 0.427586206896552 8.2 8 2 increased blood urea nitrogen level 3.88893781507589e-05 0.000992177724615515 1.14328605677668 0.427586206896552 8.2 8 2 abnormal muscle physiology 0.0011685194154473 0.0167051267007192 1.14162851990567 0.426966292134831 8.2 8 2 delayed bone ossification 0.00278846121070585 0.0324885117640787 1.14082737708469 0.426666666666667 8.2 8 2 abnormal limb morphology 0.00278846121070585 0.0324885117640787 1.14082737708469 0.426666666666667 8.2 8 2 abnormal male meiosis 0.00674696959217672 0.0620446834031038 1.13965849657538 0.426229508196721 8.2 8 2 decreased hemoglobin content 6.07292700928506e-05 0.00143188681853996 1.1377932617201 0.425531914893617 8.2 8 2 impaired ovarian folliculogenesis 0.0265117559677553 0.16549057206974 1.13637102014295 0.425 8.2 8 2 head bobbing 0.0265117559677553 0.16549057206974 1.13637102014295 0.425 8.2 8 2 microphthalmia 3.2697797583184e-05 0.000865274164767768 1.13593412240356 0.42483660130719 8.2 8 2 decreased bone mineral density 5.36235617445513e-08 2.99749685032745e-06 1.13586842349539 0.424812030075188 8.2 8 2 decreased hematocrit 4.97758855947718e-05 0.00121987699918222 1.1354553303604 0.424657534246575 8.2 8 2 increased heart weight 7.5839254931601e-05 0.00170724114608468 1.13492831465821 0.424460431654676 8.2 8 2 abnormal vascular development 0.00545721796783575 0.0539471389591594 1.13434540335125 0.424242424242424 8.2 8 2 enlarged pericardium 0.0426543493723451 0.229163486098722 1.13434540335125 0.424242424242424 8.2 8 2 dextrocardia 0.0426543493723451 0.229163486098722 1.13434540335125 0.424242424242424 8.2 8 2 abnormal ovarian folliculogenesis 0.0426543493723451 0.229163486098722 1.13434540335125 0.424242424242424 8.2 8 2 decreased brown adipose tissue amount 0.0426543493723451 0.229163486098722 1.13434540335125 0.424242424242424 8.2 8 2 increased osteoblast cell number 0.0426543493723451 0.229163486098722 1.13434540335125 0.424242424242424 8.2 8 2 circling 0.00184212337924653 0.0240539732591902 1.13243894048848 0.423529411764706 8.2 8 2 increased susceptibility to injury 0.0133829916734906 0.108895863639827 1.13122906982556 0.423076923076923 8.2 8 2 abnormal stomach morphology 0.0697808198836307 0.29580563413186 1.13122906982556 0.423076923076923 8.2 8 2 pulmonary edema 0.0697808198836307 0.29580563413186 1.13122906982556 0.423076923076923 8.2 8 2 decreased T cell number 2.7384244823107e-05 0.000733877111643137 1.12931281504889 0.422360248447205 8.2 8 2 thin ventricular wall 0.00149771430879187 0.0202476322995641 1.12894375857339 0.422222222222222 8.2 8 2 small placenta 0.0211668122795955 0.14130376353227 1.12894375857339 0.422222222222222 8.2 8 2 decreased lymphocyte cell number 0.000180237449626111 0.0036599237219996 1.12801535087719 0.421875 8.2 8 2 decreased neuron apoptosis 0.0337951756340715 0.196414718200357 1.1258164905441 0.421052631578947 8.2 8 2 irregular coat pigmentation 0.117209535211072 0.410357098997245 1.1258164905441 0.421052631578947 8.2 8 2 enlarged adrenal glands 0.117209535211072 0.410357098997245 1.1258164905441 0.421052631578947 8.2 8 2 shiny skin 0.117209535211072 0.410357098997245 1.1258164905441 0.421052631578947 8.2 8 2 abnormal neurotransmitter level 0.117209535211072 0.410357098997245 1.1258164905441 0.421052631578947 8.2 8 2 abnormal optic vesicle formation 0.117209535211072 0.410357098997245 1.1258164905441 0.421052631578947 8.2 8 2 abnormal photoreceptor inner segment morphology 0.117209535211072 0.410357098997245 1.1258164905441 0.421052631578947 8.2 8 2 increased left ventricle weight 0.117209535211072 0.410357098997245 1.1258164905441 0.421052631578947 8.2 8 2 eyelids fail to open 0.117209535211072 0.410357098997245 1.1258164905441 0.421052631578947 8.2 8 2 increased liver cholesterol level 0.117209535211072 0.410357098997245 1.1258164905441 0.421052631578947 8.2 8 2 decreased susceptibility to weight gain 0.117209535211072 0.410357098997245 1.1258164905441 0.421052631578947 8.2 8 2 shortened RR interval 0.117209535211072 0.410357098997245 1.1258164905441 0.421052631578947 8.2 8 2 teratozoospermia 0.00187611712897663 0.024433724389159 1.12421731939276 0.420454545454545 8.2 8 2 decreased spleen weight 0.00555323107333939 0.0544917644770482 1.1237769679163 0.420289855072464 8.2 8 2 abnormal circulating protein level 0.0169345749348439 0.129217040338724 1.12300194931774 0.42 8.2 8 2 abnormal heart morphology 8.50286155764473e-07 3.58489290248157e-05 1.12277045025583 0.41991341991342 8.2 8 2 abnormal nose morphology 0.054666948094056 0.269266344337845 1.12127690792094 0.419354838709677 8.2 8 2 abnormal vasculogenesis 0.0268649479486299 0.167275489417314 1.11927104583163 0.418604651162791 8.2 8 2 delayed endochondral bone ossification 0.0268649479486299 0.167275489417314 1.11927104583163 0.418604651162791 8.2 8 2 cardiac hypertrophy 0.00123785350159592 0.0176456193995407 1.11863653843604 0.418367346938776 8.2 8 2 abnormal placenta labyrinth morphology 0.00363008741265716 0.0398848840013173 1.11690971451131 0.417721518987342 8.2 8 2 abnormal myocardium layer morphology 0.00363008741265716 0.0398848840013173 1.11690971451131 0.417721518987342 8.2 8 2 short snout 0.00081788175376969 0.0125198822307822 1.11408923543426 0.416666666666667 8.2 8 2 intracranial hemorrhage 0.0108975103353666 0.0922025746912398 1.11408923543426 0.416666666666667 8.2 8 2 abnormal incisor morphology 0.0108975103353666 0.0922025746912398 1.11408923543426 0.416666666666667 8.2 8 2 oligodactyly 0.0214159240895733 0.14130376353227 1.11408923543426 0.416666666666667 8.2 8 2 thymus atrophy 0.0214159240895733 0.14130376353227 1.11408923543426 0.416666666666667 8.2 8 2 renal hypoplasia 0.043066324902159 0.230108780124294 1.11408923543426 0.416666666666667 8.2 8 2 narrow eye opening 0.043066324902159 0.230108780124294 1.11408923543426 0.416666666666667 8.2 8 2 decreased body height 0.090152975257977 0.342636403291394 1.11408923543426 0.416666666666667 8.2 8 2 curly vibrissae 0.090152975257977 0.342636403291394 1.11408923543426 0.416666666666667 8.2 8 2 small lymph nodes 0.090152975257977 0.342636403291394 1.11408923543426 0.416666666666667 8.2 8 2 abnormal primitive streak formation 0.090152975257977 0.342636403291394 1.11408923543426 0.416666666666667 8.2 8 2 abnormal lung saccule morphology 0.090152975257977 0.342636403291394 1.11408923543426 0.416666666666667 8.2 8 2 abnormal mineral level 0.206696607282934 0.564692991318933 1.11408923543426 0.416666666666667 8.2 8 2 abnormal rectum morphology 0.206696607282934 0.564692991318933 1.11408923543426 0.416666666666667 8.2 8 2 decreased digestive secretion 0.206696607282934 0.564692991318933 1.11408923543426 0.416666666666667 8.2 8 2 abnormal tracheal ciliated epithelium morphology 0.206696607282934 0.564692991318933 1.11408923543426 0.416666666666667 8.2 8 2 small thyroid gland 0.206696607282934 0.564692991318933 1.11408923543426 0.416666666666667 8.2 8 2 small intestinal inflammation 0.206696607282934 0.564692991318933 1.11408923543426 0.416666666666667 8.2 8 2 abnormal anogenital distance 0.206696607282934 0.564692991318933 1.11408923543426 0.416666666666667 8.2 8 2 abnormal amacrine cell morphology 0.206696607282934 0.564692991318933 1.11408923543426 0.416666666666667 8.2 8 2 abnormal fatty acid level 0.206696607282934 0.564692991318933 1.11408923543426 0.416666666666667 8.2 8 2 abnormal patella morphology 0.206696607282934 0.564692991318933 1.11408923543426 0.416666666666667 8.2 8 2 abnormal thymus corticomedullary boundary morphology 0.206696607282934 0.564692991318933 1.11408923543426 0.416666666666667 8.2 8 2 increased skeletal muscle glycogen level 0.206696607282934 0.564692991318933 1.11408923543426 0.416666666666667 8.2 8 2 abnormal respiratory motile cilium morphology 0.206696607282934 0.564692991318933 1.11408923543426 0.416666666666667 8.2 8 2 increased body weight 2.5262895255079e-06 9.04193553194374e-05 1.11011034530771 0.415178571428571 8.2 8 2 arrested B cell differentiation 0.0340785131024273 0.197367511662013 1.108654653798 0.414634146341463 8.2 8 2 palatal shelves fail to meet at midline 0.0340785131024273 0.197367511662013 1.108654653798 0.414634146341463 8.2 8 2 no abnormal phenotype detected 1.60132493579474e-39 2.65553051852628e-36 1.10805324764574 0.414409221902017 8.2 8 2 dermatitis 0.0137034108800654 0.110314674964928 1.10640586139679 0.413793103448276 8.2 8 2 abnormal spermiogenesis 0.0137034108800654 0.110314674964928 1.10640586139679 0.413793103448276 8.2 8 2 abnormal outer ear morphology 0.0700614234488056 0.29580563413186 1.10640586139679 0.413793103448276 8.2 8 2 short sternum 0.0700614234488056 0.29580563413186 1.10640586139679 0.413793103448276 8.2 8 2 abnormal CD8-positive, alpha-beta T cell physiology 0.0700614234488056 0.29580563413186 1.10640586139679 0.413793103448276 8.2 8 2 abnormal neurocranium morphology 0.00568569218680697 0.0553582008889733 1.10517652155079 0.413333333333333 8.2 8 2 abnormal forelimb morphology 0.0270643720946751 0.16728112912414 1.10440150295223 0.41304347826087 8.2 8 2 increased circulating aspartate transaminase level 0.010992918234929 0.0928518985038574 1.10347886176346 0.412698412698413 8.2 8 2 neonatal lethality, complete penetrance 5.64764068537099e-11 5.85354425202514e-09 1.10236198032443 0.412280701754386 8.2 8 2 abnormal gastrulation 0.0215588354529002 0.14130376353227 1.10098230325269 0.411764705882353 8.2 8 2 abnormal cervical vertebrae morphology 0.0215588354529002 0.14130376353227 1.10098230325269 0.411764705882353 8.2 8 2 abnormal gluconeogenesis 0.0215588354529002 0.14130376353227 1.10098230325269 0.411764705882353 8.2 8 2 abnormal spleen red pulp morphology 0.0548577309147679 0.269681038834951 1.10098230325268 0.411764705882353 8.2 8 2 distended urinary bladder 0.153455683470222 0.488430505411996 1.10098230325268 0.411764705882353 8.2 8 2 abnormal heart rate 0.153455683470222 0.488430505411996 1.10098230325268 0.411764705882353 8.2 8 2 increased hepatoma incidence 0.153455683470222 0.488430505411996 1.10098230325268 0.411764705882353 8.2 8 2 delayed heart development 0.153455683470222 0.488430505411996 1.10098230325268 0.411764705882353 8.2 8 2 oxidative stress 0.00299525624802166 0.0342560915722018 1.09923471229514 0.411111111111111 8.2 8 2 enhanced long term potentiation 0.0172171067682567 0.131166818651147 1.09817367492806 0.410714285714286 8.2 8 2 alopecia 0.00242320679070612 0.0289099611121414 1.0976710782805 0.410526315789474 8.2 8 2 abnormal heart looping 0.0432003217358976 0.230108780124294 1.09694940104297 0.41025641025641 8.2 8 2 acanthosis 0.0432003217358976 0.230108780124294 1.09694940104297 0.41025641025641 8.2 8 2 abnormal circulating hormone level 0.0432003217358976 0.230108780124294 1.09694940104297 0.41025641025641 8.2 8 2 enlarged spleen 2.86496287962691e-07 1.38380488603339e-05 1.09552108151036 0.409722222222222 8.2 8 2 short tail 0.00461783847387937 0.0486731915414192 1.09529736881248 0.409638554216867 8.2 8 2 insulin resistance 0.000452084995633707 0.00780945435165865 1.09383306751728 0.409090909090909 8.2 8 2 abnormal tail morphology 0.0110496754891783 0.0931731111163762 1.09383306751728 0.409090909090909 8.2 8 2 small kidney 0.00372824263430007 0.0404894394129532 1.09383306751728 0.409090909090909 8.2 8 2 increased T cell number 0.00372824263430007 0.0404894394129532 1.09383306751728 0.409090909090909 8.2 8 2 abnormal astrocyte morphology 0.0341748480201606 0.197467908130429 1.09383306751728 0.409090909090909 8.2 8 2 abnormal enterocyte morphology 0.116546529616143 0.410357098997245 1.09383306751728 0.409090909090909 8.2 8 2 intestinal inflammation 0.116546529616143 0.410357098997245 1.09383306751728 0.409090909090909 8.2 8 2 parakeratosis 0.116546529616143 0.410357098997245 1.09383306751728 0.409090909090909 8.2 8 2 abnormal female reproductive system physiology 0.116546529616143 0.410357098997245 1.09383306751728 0.409090909090909 8.2 8 2 abnormal blood-brain barrier function 0.116546529616143 0.410357098997245 1.09383306751728 0.409090909090909 8.2 8 2 decreased circulating estradiol level 0.116546529616143 0.410357098997245 1.09383306751728 0.409090909090909 8.2 8 2 abnormal occipital bone morphology 0.116546529616143 0.410357098997245 1.09383306751728 0.409090909090909 8.2 8 2 increased circulating creatine kinase level 0.116546529616143 0.410357098997245 1.09383306751728 0.409090909090909 8.2 8 2 absent kidney 0.0271348484830514 0.16728112912414 1.0913527204254 0.408163265306122 8.2 8 2 increased T cell derived lymphoma incidence 0.0271348484830514 0.16728112912414 1.0913527204254 0.408163265306122 8.2 8 2 decreased circulating creatinine level 0.0271348484830514 0.16728112912414 1.0913527204254 0.408163265306122 8.2 8 2 abnormal spleen morphology 7.06498416709154e-05 0.00163480447587351 1.09103911332183 0.408045977011494 8.2 8 2 cryptorchism 0.0897779480217632 0.342519395251742 1.08933169686906 0.407407407407407 8.2 8 2 abnormal eye muscle morphology 0.0897779480217632 0.342519395251742 1.08933169686906 0.407407407407407 8.2 8 2 increased bone mineral density 0.00129462986459492 0.0184022387895992 1.0884553238225 0.407079646017699 8.2 8 2 increased oxygen consumption 0.00463636530987043 0.0487651531006457 1.08818018344742 0.406976744186047 8.2 8 2 cyanosis 3.84830764246117e-05 0.000991986037370171 1.08623700454841 0.40625 8.2 8 2 abnormal vertebral body morphology 0.0698376762220756 0.29580563413186 1.08623700454841 0.40625 8.2 8 2 kidney cortex cysts 0.0698376762220756 0.29580563413186 1.08623700454841 0.40625 8.2 8 2 increased circulating follicle stimulating hormone level 0.0698376762220756 0.29580563413186 1.08623700454841 0.40625 8.2 8 2 abnormal diaphragm morphology 0.0698376762220756 0.29580563413186 1.08623700454841 0.40625 8.2 8 2 bradykinesia 0.0698376762220756 0.29580563413186 1.08623700454841 0.40625 8.2 8 2 abnormal sternum morphology 0.0110721982227959 0.0932050527215054 1.08502603798815 0.405797101449275 8.2 8 2 increased brown adipose tissue amount 0.0547192510805149 0.269266344337845 1.08397871555766 0.405405405405405 8.2 8 2 impaired skeletal muscle contractility 0.0547192510805149 0.269266344337845 1.08397871555766 0.405405405405405 8.2 8 2 abnormal pancreatic beta cell physiology 0.0547192510805149 0.269266344337845 1.08397871555766 0.405405405405405 8.2 8 2 abnormal chromosome morphology 0.0547192510805149 0.269266344337845 1.08397871555766 0.405405405405405 8.2 8 2 abnormal eye electrophysiology 0.00105293444754422 0.0154360623758822 1.08278424865347 0.40495867768595 8.2 8 2 hydronephrosis 0.00576005119179098 0.0557514682473932 1.08225811442186 0.404761904761905 8.2 8 2 increased food intake 0.00576005119179098 0.0557514682473932 1.08225811442186 0.404761904761905 8.2 8 2 skin edema 0.0431123139947175 0.230108780124294 1.08225811442186 0.404761904761905 8.2 8 2 abnormal spleen white pulp morphology 0.0431123139947175 0.230108780124294 1.08225811442186 0.404761904761905 8.2 8 2 increased respiratory quotient 0.0341178010109209 0.197367511662013 1.0809035986341 0.404255319148936 8.2 8 2 abnormal snout morphology 0.0270973102712099 0.16728112912414 1.07980956665167 0.403846153846154 8.2 8 2 abnormal female meiosis 0.0270973102712099 0.16728112912414 1.07980956665167 0.403846153846154 8.2 8 2 absent vitelline blood vessels 0.0215861025697537 0.14130376353227 1.07890747010476 0.403508771929825 8.2 8 2 abnormal circulating amino acid level 0.0215861025697537 0.14130376353227 1.07890747010476 0.403508771929825 8.2 8 2 decreased white adipose tissue amount 0.0137980740210486 0.110897283125552 1.07750720083792 0.402985074626866 8.2 8 2 abnormal retinal pigmentation 0.00575758383641417 0.0557514682473932 1.07567236524688 0.402298850574713 8.2 8 2 decreased neutrophil cell number 0.00160449064188555 0.0215157437826971 1.07409628852124 0.401709401709402 8.2 8 2 abnormal rib morphology 0.000854092034968496 0.0130340732330315 1.06952566601689 0.4 8.2 8 2 enlarged liver 0.00373960512515168 0.0404894394129532 1.06952566601689 0.4 8.2 8 2 decreased heart rate 0.00373960512515168 0.0404894394129532 1.06952566601689 0.4 8.2 8 2 cardiac fibrosis 0.00712988048942257 0.0641431382185846 1.06952566601689 0.4 8.2 8 2 abnormal long bone epiphyseal plate morphology 0.0214954346723933 0.14130376353227 1.06952566601689 0.4 8.2 8 2 increased erythrocyte cell number 0.0214954346723933 0.14130376353227 1.06952566601689 0.4 8.2 8 2 abnormal interventricular septum morphology 0.0339350308485233 0.196997407784601 1.06952566601689 0.4 8.2 8 2 albuminuria 0.0428468718472043 0.229949501013853 1.06952566601689 0.4 8.2 8 2 abnormal female reproductive system morphology 0.0543260322479926 0.268660050132965 1.06952566601689 0.4 8.2 8 2 abnormal pancreatic beta cell morphology 0.0543260322479926 0.268660050132965 1.06952566601689 0.4 8.2 8 2 abnormal dermal layer morphology 0.0692403306002396 0.29580563413186 1.06952566601689 0.4 8.2 8 2 decreased triglyceride level 0.0692403306002396 0.29580563413186 1.06952566601689 0.4 8.2 8 2 decreased glycogen level 0.0692403306002396 0.29580563413186 1.06952566601689 0.4 8.2 8 2 impaired behavioral response to xenobiotic 0.0692403306002396 0.29580563413186 1.06952566601689 0.4 8.2 8 2 increased red blood cell distribution width 0.0692403306002396 0.29580563413186 1.06952566601689 0.4 8.2 8 2 arrested T cell differentiation 0.0888399575189807 0.341296361897242 1.06952566601689 0.4 8.2 8 2 abnormal lactation 0.0888399575189807 0.341296361897242 1.06952566601689 0.4 8.2 8 2 disorganized myocardium 0.0888399575189807 0.341296361897242 1.06952566601689 0.4 8.2 8 2 abnormal cellular respiration 0.0888399575189807 0.341296361897242 1.06952566601689 0.4 8.2 8 2 decreased placenta weight 0.115004827464284 0.410357098997245 1.06952566601689 0.4 8.2 8 2 abnormal pericardium morphology 0.150745634354568 0.48793723546778 1.06952566601689 0.4 8.2 8 2 increased urine glucose level 0.150745634354568 0.48793723546778 1.06952566601689 0.4 8.2 8 2 decreased myocardial infarction size 0.150745634354568 0.48793723546778 1.06952566601689 0.4 8.2 8 2 abnormal thymocyte activation 0.150745634354568 0.48793723546778 1.06952566601689 0.4 8.2 8 2 abnormal optic stalk morphology 0.150745634354568 0.48793723546778 1.06952566601689 0.4 8.2 8 2 nuclear cataracts 0.150745634354568 0.48793723546778 1.06952566601689 0.4 8.2 8 2 abnormal fontanelle morphology 0.201384079545863 0.564692991318933 1.06952566601689 0.4 8.2 8 2 audiogenic seizures 0.201384079545863 0.564692991318933 1.06952566601689 0.4 8.2 8 2 absent egg cylinders 0.201384079545863 0.564692991318933 1.06952566601689 0.4 8.2 8 2 abnormal glial cell morphology 0.201384079545863 0.564692991318933 1.06952566601689 0.4 8.2 8 2 abnormal ear development 0.201384079545863 0.564692991318933 1.06952566601689 0.4 8.2 8 2 abnormal secondary palate development 0.201384079545863 0.564692991318933 1.06952566601689 0.4 8.2 8 2 ostium primum atrial septal defect 0.201384079545863 0.564692991318933 1.06952566601689 0.4 8.2 8 2 increased sensitivity to xenobiotic induced morbidity/mortality 0.00244379515914328 0.0290330010179207 1.06952566601689 0.4 8.2 8 2 increased circulating calcium level 0.0269694311692194 0.16728112912414 1.06952566601689 0.4 8.2 8 2 decreased circulating calcium level 0.0269694311692194 0.16728112912414 1.06952566601689 0.4 8.2 8 2 hyperglycemia 0.0070977148189423 0.0639694406236195 1.0634488156418 0.397727272727273 8.2 8 2 retinal degeneration 0.0056860383224654 0.0553582008889733 1.05838477366255 0.395833333333333 8.2 8 2 small spleen 0.00705356502461258 0.063686907436384 1.05777263672001 0.395604395604396 8.2 8 2 abnormal left-right axis patterning 0.053735591794082 0.267602171346905 1.05708932106321 0.395348837209302 8.2 8 2 decreased oxygen consumption 0.053735591794082 0.267602171346905 1.05708932106321 0.395348837209302 8.2 8 2 increased exploration in new environment 0.0108941718097094 0.0922025746912398 1.05632164544878 0.395061728395062 8.2 8 2 abnormal frontal bone morphology 0.0683653872412392 0.29580563413186 1.05545295988509 0.394736842105263 8.2 8 2 corneal opacity 0.0169260194536652 0.129217040338724 1.05446192424201 0.394366197183099 8.2 8 2 abnormal kidney morphology 0.000296297661163813 0.00543941278335782 1.05424672793094 0.394285714285714 8.2 8 2 impaired swimming 0.0211555918110793 0.14130376353227 1.0533207316833 0.393939393939394 8.2 8 2 abnormal seminal vesicle morphology 0.0332797587227834 0.193669077366243 1.05042699340945 0.392857142857143 8.2 8 2 abnormal circulating cholesterol level 0.112896507483675 0.407197519396755 1.05042699340945 0.392857142857143 8.2 8 2 enhanced coordination 0.112896507483675 0.407197519396755 1.05042699340945 0.392857142857143 8.2 8 2 abnormal renal tubule epithelium morphology 0.112896507483675 0.407197519396755 1.05042699340945 0.392857142857143 8.2 8 2 subcutaneous edema 0.112896507483675 0.407197519396755 1.05042699340945 0.392857142857143 8.2 8 2 abnormal visceral yolk sac morphology 0.0134396101054982 0.108895863639827 1.04921821666214 0.392405063291139 8.2 8 2 increased lung adenocarcinoma incidence 0.0419196730392476 0.226685188445931 1.04855457452637 0.392156862745098 8.2 8 2 increased kidney weight 0.0419196730392476 0.226685188445931 1.04855457452637 0.392156862745098 8.2 8 2 increased granulocyte number 0.01675370336548 0.128230268066558 1.04784609170574 0.391891891891892 8.2 8 2 abnormal coat appearance 0.0209224586237194 0.14130376353227 1.04627510806001 0.391304347826087 8.2 8 2 abnormal innervation pattern to muscle 0.147231416300918 0.48062749087734 1.04627510806001 0.391304347826087 8.2 8 2 abnormal circulating insulin level 0.147231416300918 0.48062749087734 1.04627510806001 0.391304347826087 8.2 8 2 decreased epididymis weight 0.147231416300918 0.48062749087734 1.04627510806001 0.391304347826087 8.2 8 2 dilated heart 0.147231416300918 0.48062749087734 1.04627510806001 0.391304347826087 8.2 8 2 abnormal ulna morphology 0.147231416300918 0.48062749087734 1.04627510806001 0.391304347826087 8.2 8 2 abnormal corneal stroma morphology 0.147231416300918 0.48062749087734 1.04627510806001 0.391304347826087 8.2 8 2 abnormal chondrocyte physiology 0.147231416300918 0.48062749087734 1.04627510806001 0.391304347826087 8.2 8 2 abnormal osteoclast physiology 0.026182162595381 0.16384435083273 1.04445865821962 0.390625 8.2 8 2 thick ventricular wall 0.0672844445011542 0.29580563413186 1.04343967416282 0.390243902439024 8.2 8 2 short humerus 0.0672844445011542 0.29580563413186 1.04343967416282 0.390243902439024 8.2 8 2 hemopericardium 0.0672844445011542 0.29580563413186 1.04343967416282 0.390243902439024 8.2 8 2 increased bone trabecula number 0.0672844445011542 0.29580563413186 1.04343967416282 0.390243902439024 8.2 8 2 abnormal glucose homeostasis 0.000352837790804525 0.00631427341457738 1.04308135009889 0.39010989010989 8.2 8 2 abnormal digit morphology 0.0206560886857179 0.14130376353227 1.03981661973865 0.388888888888889 8.2 8 2 increased cell proliferation 0.0413101008809835 0.223875546713391 1.03981661973865 0.388888888888889 8.2 8 2 abnormal small intestine morphology 0.0413101008809835 0.223875546713391 1.03981661973865 0.388888888888889 8.2 8 2 heart right ventricle hypertrophy 0.0858965160444727 0.334378065196598 1.03981661973865 0.388888888888889 8.2 8 2 abnormal retinal blood vessel morphology 0.0858965160444727 0.334378065196598 1.03981661973865 0.388888888888889 8.2 8 2 abnormal stomach glandular epithelium morphology 0.195038887840499 0.559906789963348 1.03981661973865 0.388888888888889 8.2 8 2 cortical renal glomerulopathies 0.195038887840499 0.559906789963348 1.03981661973865 0.388888888888889 8.2 8 2 abnormal retinal rod cell morphology 0.195038887840499 0.559906789963348 1.03981661973865 0.388888888888889 8.2 8 2 thick dermal layer 0.195038887840499 0.559906789963348 1.03981661973865 0.388888888888889 8.2 8 2 blepharoptosis 0.195038887840499 0.559906789963348 1.03981661973865 0.388888888888889 8.2 8 2 abnormal thymus medulla morphology 0.195038887840499 0.559906789963348 1.03981661973865 0.388888888888889 8.2 8 2 increased circulating renin level 0.195038887840499 0.559906789963348 1.03981661973865 0.388888888888889 8.2 8 2 increased circulating glycerol level 0.195038887840499 0.559906789963348 1.03981661973865 0.388888888888889 8.2 8 2 abnormal anterior eye segment morphology 0.195038887840499 0.559906789963348 1.03981661973865 0.388888888888889 8.2 8 2 darkened coat color 0.195038887840499 0.559906789963348 1.03981661973865 0.388888888888889 8.2 8 2 decreased pulmonary respiratory rate 0.195038887840499 0.559906789963348 1.03981661973865 0.388888888888889 8.2 8 2 small thoracic cage 0.195038887840499 0.559906789963348 1.03981661973865 0.388888888888889 8.2 8 2 abnormal aerobic respiration 0.195038887840499 0.559906789963348 1.03981661973865 0.388888888888889 8.2 8 2 abnormal metanephric mesenchyme morphology 0.195038887840499 0.559906789963348 1.03981661973865 0.388888888888889 8.2 8 2 increased total body fat amount 0.00230140410361883 0.027836878325899 1.03759952673281 0.388059701492537 8.2 8 2 abnormal long bone hypertrophic chondrocyte zone 0.0521328059036 0.2611890325986 1.03678508440413 0.387755102040816 8.2 8 2 abnormal epidermis stratum corneum morphology 0.0521328059036 0.2611890325986 1.03678508440413 0.387755102040816 8.2 8 2 abnormal retinal pigment epithelium morphology 0.0163357557359425 0.126663805599253 1.03610298895387 0.3875 8.2 8 2 respiratory distress 0.000640500136685861 0.0103764488632401 1.03552340495855 0.38728323699422 8.2 8 2 prenatal lethality 0.0323489952112971 0.191590775209766 1.03502483808087 0.387096774193548 8.2 8 2 decreased thymus weight 0.110422910839986 0.40216250470639 1.03502483808087 0.387096774193548 8.2 8 2 abnormal podocyte morphology 0.110422910839986 0.40216250470639 1.03502483808087 0.387096774193548 8.2 8 2 cochlear hair cell degeneration 0.0660516156517365 0.29580563413186 1.03306456376632 0.386363636363636 8.2 8 2 decreased blood urea nitrogen level 0.0660516156517365 0.29580563413186 1.03306456376632 0.386363636363636 8.2 8 2 abnormal craniofacial bone morphology 0.0406300568761166 0.221153755972298 1.03199844966542 0.385964912280702 8.2 8 2 increased urine protein level 0.0200451343880846 0.140096023255472 1.02839006347778 0.384615384615385 8.2 8 2 decreased B-1 B cell number 0.0840935531820779 0.329941188549556 1.02839006347778 0.384615384615385 8.2 8 2 abnormal response to injury 0.0840935531820779 0.329941188549556 1.02839006347778 0.384615384615385 8.2 8 2 abnormal kidney cortex morphology 0.143269832202192 0.48062749087734 1.02839006347778 0.384615384615385 8.2 8 2 abnormal Schwann cell morphology 0.143269832202192 0.48062749087734 1.02839006347778 0.384615384615385 8.2 8 2 increased leukemia incidence 0.143269832202192 0.48062749087734 1.02839006347778 0.384615384615385 8.2 8 2 abnormal renal/urinary system morphology 0.264929353743901 0.596029250761023 1.02839006347778 0.384615384615385 8.2 8 2 increased foot pad pigmentation 0.264929353743901 0.596029250761023 1.02839006347778 0.384615384615385 8.2 8 2 pup cannibalization 0.264929353743901 0.596029250761023 1.02839006347778 0.384615384615385 8.2 8 2 increased pituitary adenoma incidence 0.264929353743901 0.596029250761023 1.02839006347778 0.384615384615385 8.2 8 2 abnormal soleus morphology 0.264929353743901 0.596029250761023 1.02839006347778 0.384615384615385 8.2 8 2 small otic vesicle 0.264929353743901 0.596029250761023 1.02839006347778 0.384615384615385 8.2 8 2 small interparietal bone 0.264929353743901 0.596029250761023 1.02839006347778 0.384615384615385 8.2 8 2 abnormal exocrine pancreas morphology 0.264929353743901 0.596029250761023 1.02839006347778 0.384615384615385 8.2 8 2 increased circulating ammonia level 0.264929353743901 0.596029250761023 1.02839006347778 0.384615384615385 8.2 8 2 increased circulating thyroxine level 0.264929353743901 0.596029250761023 1.02839006347778 0.384615384615385 8.2 8 2 abnormal lipid homeostasis 0.0034099295665027 0.0378669633780155 1.02839006347778 0.384615384615385 8.2 8 2 decreased bone marrow cell number 0.0250011807945762 0.158427035562119 1.02557255645456 0.383561643835616 8.2 8 2 hepatic necrosis 0.0647082591527785 0.293458148846922 1.02401393554809 0.382978723404255 8.2 8 2 abnormal lens morphology 0.00414294659438799 0.0440409386903424 1.02356948505523 0.3828125 8.2 8 2 short maxilla 0.10771819109703 0.393464024014481 1.02234071016321 0.382352941176471 8.2 8 2 abnormal brown adipose tissue morphology 0.10771819109703 0.393464024014481 1.02234071016321 0.382352941176471 8.2 8 2 abnormal enzyme/coenzyme activity 0.00172406216897296 0.0226910298694193 1.0218398082964 0.382165605095541 8.2 8 2 abnormal joint morphology 0.0501675733500142 0.256141234641433 1.02091086301613 0.381818181818182 8.2 8 2 abnormal muscle morphology 0.0821596017358845 0.322862573962105 1.01859587239704 0.380952380952381 8.2 8 2 abnormal cytotoxic T cell physiology 0.0821596017358845 0.322862573962105 1.01859587239704 0.380952380952381 8.2 8 2 abnormal anxiety-related response 0.188299807888128 0.546871888058049 1.01859587239704 0.380952380952381 8.2 8 2 abnormal clavicle morphology 0.188299807888128 0.546871888058049 1.01859587239704 0.380952380952381 8.2 8 2 increased bone ossification 0.188299807888128 0.546871888058049 1.01859587239704 0.380952380952381 8.2 8 2 increased muscle cell glucose uptake 0.188299807888128 0.546871888058049 1.01859587239704 0.380952380952381 8.2 8 2 abnormal hair follicle morphology 0.0391181849596198 0.213157689128268 1.01859587239704 0.380952380952381 8.2 8 2 increased circulating cholesterol level 0.00109136782096034 0.015737840316747 1.01787243782858 0.380681818181818 8.2 8 2 increased body length 0.0632862809373568 0.291371581809916 1.01604938271605 0.38 8.2 8 2 kidney inflammation 0.0632862809373568 0.291371581809916 1.01604938271605 0.38 8.2 8 2 decreased respiratory quotient 0.0632862809373568 0.291371581809916 1.01604938271605 0.38 8.2 8 2 decreased B cell proliferation 0.0240893329284436 0.154598469844002 1.01537246773756 0.379746835443038 8.2 8 2 increased circulating triglyceride level 0.00315133855008654 0.0357943134399099 1.01420537294705 0.379310344827586 8.2 8 2 short limbs 0.0189962723691438 0.138572514716261 1.01420537294705 0.379310344827586 8.2 8 2 abnormal long bone metaphysis morphology 0.104873981674708 0.389946232310666 1.01171346785382 0.378378378378378 8.2 8 2 increased circulating phosphate level 0.104873981674708 0.389946232310666 1.01171346785382 0.378378378378378 8.2 8 2 abnormal calcium ion homeostasis 0.104873981674708 0.389946232310666 1.01171346785382 0.378378378378378 8.2 8 2 increased trabecular bone volume 0.104873981674708 0.389946232310666 1.01171346785382 0.378378378378378 8.2 8 2 abnormal ectoderm development 0.0801402101044882 0.31542527315651 1.0101075734604 0.377777777777778 8.2 8 2 increased circulating corticosterone level 0.0801402101044882 0.31542527315651 1.0101075734604 0.377777777777778 8.2 8 2 abnormal metabolism 0.0801402101044882 0.31542527315651 1.0101075734604 0.377777777777778 8.2 8 2 abnormal pancreatic islet morphology 0.0618104830407532 0.291371581809916 1.00898647737443 0.377358490566038 8.2 8 2 abnormal pulmonary alveolus morphology 0.0144332170692899 0.115814927289866 1.00598948783767 0.376237623762376 8.2 8 2 abnormal skin pigmentation 0.101954065742529 0.380511235610714 1.00268031189084 0.375 8.2 8 2 cochlear outer hair cell degeneration 0.0366319829041465 0.210200824622986 1.00268031189084 0.375 8.2 8 2 decreased eosinophil cell number 0.0468797983781628 0.248113826522723 1.00268031189084 0.375 8.2 8 2 polydipsia 0.134774051610732 0.454268907021267 1.00268031189084 0.375 8.2 8 2 neonatal lethality 0.134774051610732 0.454268907021267 1.00268031189084 0.375 8.2 8 2 increased fatty acid level 0.134774051610732 0.454268907021267 1.00268031189084 0.375 8.2 8 2 abnormal startle reflex 0.181478480926682 0.530230787980701 1.00268031189084 0.375 8.2 8 2 abnormal cardiac muscle contractility 0.181478480926682 0.530230787980701 1.00268031189084 0.375 8.2 8 2 abnormal tympanic ring morphology 0.252320894314537 0.596029250761023 1.00268031189084 0.375 8.2 8 2 abnormal bone marrow cell number 0.252320894314537 0.596029250761023 1.00268031189084 0.375 8.2 8 2 disorganized retinal layers 0.252320894314537 0.596029250761023 1.00268031189084 0.375 8.2 8 2 intraventricular hemorrhage 0.252320894314537 0.596029250761023 1.00268031189084 0.375 8.2 8 2 white spotting 0.252320894314537 0.596029250761023 1.00268031189084 0.375 8.2 8 2 abnormal epicardium morphology 0.252320894314537 0.596029250761023 1.00268031189084 0.375 8.2 8 2 impaired muscle relaxation 0.252320894314537 0.596029250761023 1.00268031189084 0.375 8.2 8 2 abnormal amnion morphology 0.252320894314537 0.596029250761023 1.00268031189084 0.375 8.2 8 2 decreased B cell number 0.000911927678688194 0.0137480006105266 0.999435391787632 0.37378640776699 8.2 8 2 decreased litter size 0.000125647789802881 0.0026819838307241 0.999112054553148 0.373665480427046 8.2 8 2 abnormal thoracic vertebrae morphology 0.0587708564822251 0.285253669267385 0.997015451371681 0.372881355932203 8.2 8 2 increased hemoglobin content 0.0587708564822251 0.285253669267385 0.997015451371681 0.372881355932203 8.2 8 2 distended abdomen 0.0759727043768593 0.303098800541199 0.996126845800048 0.372549019607843 8.2 8 2 abnormal organ of Corti morphology 0.0990034594791748 0.369776434616287 0.994907596294785 0.372093023255814 8.2 8 2 cataract 0.0105044243794085 0.0893324979274483 0.99439369774298 0.371900826446281 8.2 8 2 thick epidermis 0.0446009274700404 0.23630416843818 0.993130975587116 0.371428571428571 8.2 8 2 abnormal intestinal goblet cell morphology 0.130455108663315 0.441206094901422 0.993130975587116 0.371428571428571 8.2 8 2 decreased IgM level 0.0211211098166375 0.14130376353227 0.992343401458974 0.371134020618557 8.2 8 2 abnormal heart valve morphology 0.174735646425975 0.530230787980701 0.990301542608235 0.37037037037037 8.2 8 2 rectal prolapse 0.174735646425975 0.530230787980701 0.990301542608235 0.37037037037037 8.2 8 2 thin epidermis 0.174735646425975 0.530230787980701 0.990301542608235 0.37037037037037 8.2 8 2 abnormal type II pneumocyte morphology 0.174735646425975 0.530230787980701 0.990301542608235 0.37037037037037 8.2 8 2 abnormal fetal cardiomyocyte proliferation 0.174735646425975 0.530230787980701 0.990301542608235 0.37037037037037 8.2 8 2 abnormal liver physiology 0.0206197859522699 0.14130376353227 0.989311241065627 0.37 8.2 8 2 abnormal axial skeleton morphology 0.042321878381809 0.228611666611835 0.985089429226087 0.368421052631579 8.2 8 2 small superior vagus ganglion 0.240439343540998 0.596029250761023 0.985089429226087 0.368421052631579 8.2 8 2 thin dermal layer 0.240439343540998 0.596029250761023 0.985089429226087 0.368421052631579 8.2 8 2 decreased tumor incidence 0.240439343540998 0.596029250761023 0.985089429226087 0.368421052631579 8.2 8 2 abnormal neural crest cell migration 0.240439343540998 0.596029250761023 0.985089429226087 0.368421052631579 8.2 8 2 abnormal response to novelty 0.240439343540998 0.596029250761023 0.985089429226087 0.368421052631579 8.2 8 2 oliguria 0.240439343540998 0.596029250761023 0.985089429226087 0.368421052631579 8.2 8 2 decreased food intake 0.041194372803307 0.223735812987393 0.981526718812972 0.367088607594937 8.2 8 2 liver inflammation 0.0147925032605788 0.117937025194519 0.980398527182153 0.366666666666667 8.2 8 2 abnormal hair cycle 0.168156082409162 0.523994075685302 0.980398527182153 0.366666666666667 8.2 8 2 increased metastatic potential 0.168156082409162 0.523994075685302 0.980398527182153 0.366666666666667 8.2 8 2 delayed eyelid opening 0.168156082409162 0.523994075685302 0.980398527182153 0.366666666666667 8.2 8 2 abnormal response to new environment 0.168156082409162 0.523994075685302 0.980398527182153 0.366666666666667 8.2 8 2 abnormal estrous cycle 0.168156082409162 0.523994075685302 0.980398527182153 0.366666666666667 8.2 8 2 abnormal microglial cell physiology 0.168156082409162 0.523994075685302 0.980398527182153 0.366666666666667 8.2 8 2 abnormal fat pad morphology 0.168156082409162 0.523994075685302 0.980398527182153 0.366666666666667 8.2 8 2 atelectasis 0.052666650299883 0.263598174287644 0.979143215367579 0.366197183098592 8.2 8 2 increased leukocyte cell number 0.0086849713880321 0.0756702848607 0.977325177567162 0.36551724137931 8.2 8 2 abnormal skin condition 0.0902451903630463 0.342725055004699 0.976970560303894 0.365384615384615 8.2 8 2 abnormal angiogenesis 0.051178100341062 0.256923359431669 0.975580844001897 0.364864864864865 8.2 8 2 abnormal bone mineralization 0.0172428340498191 0.131166818651147 0.972296060015358 0.363636363636364 8.2 8 2 obese 0.0497134355057652 0.256141234641433 0.972296060015358 0.363636363636364 8.2 8 2 polyuria 0.0497134355057652 0.256141234641433 0.972296060015358 0.363636363636364 8.2 8 2 abnormal tooth development 0.16178388757435 0.507487289207057 0.972296060015358 0.363636363636364 8.2 8 2 abnormal epidermis stratum basale morphology 0.16178388757435 0.507487289207057 0.972296060015358 0.363636363636364 8.2 8 2 dilated heart atrium 0.16178388757435 0.507487289207057 0.972296060015358 0.363636363636364 8.2 8 2 diarrhea 0.16178388757435 0.507487289207057 0.972296060015358 0.363636363636364 8.2 8 2 myeloid hyperplasia 0.16178388757435 0.507487289207057 0.972296060015358 0.363636363636364 8.2 8 2 abnormal long bone epiphysis morphology 0.229301681186406 0.596029250761023 0.972296060015358 0.363636363636364 8.2 8 2 abnormal facial nerve morphology 0.229301681186406 0.596029250761023 0.972296060015358 0.363636363636364 8.2 8 2 abnormal oogenesis 0.229301681186406 0.596029250761023 0.972296060015358 0.363636363636364 8.2 8 2 testis hypoplasia 0.229301681186406 0.596029250761023 0.972296060015358 0.363636363636364 8.2 8 2 increased skin papilloma incidence 0.229301681186406 0.596029250761023 0.972296060015358 0.363636363636364 8.2 8 2 increased myocardial infarction size 0.229301681186406 0.596029250761023 0.972296060015358 0.363636363636364 8.2 8 2 aphakia 0.229301681186406 0.596029250761023 0.972296060015358 0.363636363636364 8.2 8 2 abnormal tracheal cartilage morphology 0.229301681186406 0.596029250761023 0.972296060015358 0.363636363636364 8.2 8 2 decreased cardiac output 0.229301681186406 0.596029250761023 0.972296060015358 0.363636363636364 8.2 8 2 rough coat 0.229301681186406 0.596029250761023 0.972296060015358 0.363636363636364 8.2 8 2 kinked tail 0.0282427267461301 0.172613716906631 0.969912981436889 0.362745098039216 8.2 8 2 abnormal B cell differentiation 0.036834971058648 0.211122097945592 0.969624916993338 0.362637362637363 8.2 8 2 abnormal food intake 0.0636623489531654 0.291371581809916 0.968773248203708 0.36231884057971 8.2 8 2 perimembraneous ventricular septal defect 0.0636623489531654 0.291371581809916 0.968773248203708 0.36231884057971 8.2 8 2 cleft secondary palate 0.0357923926088629 0.206574423699644 0.967124272462085 0.361702127659574 8.2 8 2 abnormal tibia morphology 0.11381694668037 0.407953393180721 0.967124272462085 0.361702127659574 8.2 8 2 abnormal uterus morphology 0.15564040014353 0.490070247287381 0.965544004043029 0.361111111111111 8.2 8 2 short radius 0.15564040014353 0.490070247287381 0.965544004043029 0.361111111111111 8.2 8 2 head tilt 0.15564040014353 0.490070247287381 0.965544004043029 0.361111111111111 8.2 8 2 abnormal hindlimb morphology 0.109916045215753 0.400903464038396 0.962573099415205 0.36 8.2 8 2 testicular atrophy 0.109916045215753 0.400903464038396 0.962573099415205 0.36 8.2 8 2 abnormal inner ear vestibule morphology 0.218869910999282 0.588264617623677 0.962573099415205 0.36 8.2 8 2 abnormal keratinocyte physiology 0.218869910999282 0.588264617623677 0.962573099415205 0.36 8.2 8 2 abnormal tooth morphology 0.0793031769183861 0.312873358579676 0.960901965562053 0.359375 8.2 8 2 small lens 0.149733842565037 0.487198081596508 0.959830725912597 0.358974358974359 8.2 8 2 abnormal iris morphology 0.149733842565037 0.487198081596508 0.959830725912597 0.358974358974359 8.2 8 2 abnormal coat/ hair morphology 0.10613517386668 0.390416347369453 0.958537153505707 0.358490566037736 8.2 8 2 abnormal vertebrae morphology 0.0309119301371316 0.184839966865661 0.956685802171075 0.357798165137615 8.2 8 2 abnormal cartilage morphology 0.14406475284318 0.48062749087734 0.954933630372227 0.357142857142857 8.2 8 2 abnormal pancreas morphology 0.14406475284318 0.48062749087734 0.954933630372227 0.357142857142857 8.2 8 2 rib bifurcation 0.20909072361614 0.564692991318933 0.954933630372227 0.357142857142857 8.2 8 2 abnormal respiration 0.20909072361614 0.564692991318933 0.954933630372227 0.357142857142857 8.2 8 2 hypoxia 0.20909072361614 0.564692991318933 0.954933630372227 0.357142857142857 8.2 8 2 increased triglyceride level 0.20909072361614 0.564692991318933 0.954933630372227 0.357142857142857 8.2 8 2 translucent skin 0.326151403704565 0.642615141952559 0.954933630372227 0.357142857142857 8.2 8 2 abnormal pinna reflex 0.326151403704565 0.642615141952559 0.954933630372227 0.357142857142857 8.2 8 2 abnormal olfactory system physiology 0.326151403704565 0.642615141952559 0.954933630372227 0.357142857142857 8.2 8 2 increased lactate dehydrogenase level 0.326151403704565 0.642615141952559 0.954933630372227 0.357142857142857 8.2 8 2 abnormal kidney medulla morphology 0.326151403704565 0.642615141952559 0.954933630372227 0.357142857142857 8.2 8 2 abnormal prepulse inhibition 0.326151403704565 0.642615141952559 0.954933630372227 0.357142857142857 8.2 8 2 intestinal obstruction 0.326151403704565 0.642615141952559 0.954933630372227 0.357142857142857 8.2 8 2 amyloid beta deposits 0.326151403704565 0.642615141952559 0.954933630372227 0.357142857142857 8.2 8 2 failure of zygotic cell division 0.326151403704565 0.642615141952559 0.954933630372227 0.357142857142857 8.2 8 2 abnormal vascular endothelial cell migration 0.326151403704565 0.642615141952559 0.954933630372227 0.357142857142857 8.2 8 2 skeletal muscle necrosis 0.326151403704565 0.642615141952559 0.954933630372227 0.357142857142857 8.2 8 2 abnormal iris pigmentation 0.326151403704565 0.642615141952559 0.954933630372227 0.357142857142857 8.2 8 2 increased circulating growth hormone level 0.326151403704565 0.642615141952559 0.954933630372227 0.357142857142857 8.2 8 2 abnormal viscerocranium morphology 0.326151403704565 0.642615141952559 0.954933630372227 0.357142857142857 8.2 8 2 abnormal glucose tolerance 0.326151403704565 0.642615141952559 0.954933630372227 0.357142857142857 8.2 8 2 decreased compact bone area 0.326151403704565 0.642615141952559 0.954933630372227 0.357142857142857 8.2 8 2 abnormal vitelline vein topology 0.326151403704565 0.642615141952559 0.954933630372227 0.357142857142857 8.2 8 2 pale kidney 0.19990932677221 0.564692991318933 0.948772768240793 0.354838709677419 8.2 8 2 abnormal response to infection 0.0672272185879881 0.29580563413186 0.947680969888387 0.354430379746835 8.2 8 2 abnormal cardiovascular system morphology 0.133420449661569 0.450622360533813 0.946975850119125 0.354166666666667 8.2 8 2 abnormal lung morphology 0.0324518131824899 0.19197118975373 0.94369911707373 0.352941176470588 8.2 8 2 abnormal retinal photoreceptor morphology 0.19127426747107 0.554862670943776 0.94369911707373 0.352941176470588 8.2 8 2 lung hemorrhage 0.19127426747107 0.554862670943776 0.94369911707373 0.352941176470588 8.2 8 2 abnormal adipose tissue morphology 0.306247372956892 0.610898428412404 0.94369911707373 0.352941176470588 8.2 8 2 abnormal urinary bladder morphology 0.306247372956892 0.610898428412404 0.94369911707373 0.352941176470588 8.2 8 2 enlarged sebaceous gland 0.306247372956892 0.610898428412404 0.94369911707373 0.352941176470588 8.2 8 2 abnormal vagus nerve morphology 0.306247372956892 0.610898428412404 0.94369911707373 0.352941176470588 8.2 8 2 abnormal cranial suture morphology 0.306247372956892 0.610898428412404 0.94369911707373 0.352941176470588 8.2 8 2 abnormal duodenum morphology 0.306247372956892 0.610898428412404 0.94369911707373 0.352941176470588 8.2 8 2 increased circulating magnesium level 0.306247372956892 0.610898428412404 0.94369911707373 0.352941176470588 8.2 8 2 abnormal survival 0.306247372956892 0.610898428412404 0.94369911707373 0.352941176470588 8.2 8 2 increased trabecular bone mass 0.306247372956892 0.610898428412404 0.94369911707373 0.352941176470588 8.2 8 2 abnormal ductus venosus valve morphology 0.306247372956892 0.610898428412404 0.94369911707373 0.352941176470588 8.2 8 2 abnormal cell cytoskeleton morphology 0.306247372956892 0.610898428412404 0.94369911707373 0.352941176470588 8.2 8 2 abnormal hair follicle development 0.183138876814142 0.533440229596227 0.939448220149975 0.351351351351351 8.2 8 2 increased circulating insulin level 0.0184452094522286 0.137293299418972 0.935834957764782 0.35 8.2 8 2 epidermal hyperplasia 0.114685192146673 0.410357098997245 0.935834957764782 0.35 8.2 8 2 abnormal basioccipital bone morphology 0.288735956179845 0.601397602461656 0.935834957764782 0.35 8.2 8 2 abnormal male reproductive system physiology 0.288735956179845 0.601397602461656 0.935834957764782 0.35 8.2 8 2 abnormal physiological neovascularization 0.288735956179845 0.601397602461656 0.935834957764782 0.35 8.2 8 2 abnormal incus morphology 0.288735956179845 0.601397602461656 0.935834957764782 0.35 8.2 8 2 abnormal response to tactile stimuli 0.288735956179845 0.601397602461656 0.935834957764782 0.35 8.2 8 2 absent ductus venosus valve 0.288735956179845 0.601397602461656 0.935834957764782 0.35 8.2 8 2 abnormal homeostasis 0.168204731431041 0.523994075685302 0.932725871526361 0.348837209302326 8.2 8 2 abnormal blood circulation 0.168204731431041 0.523994075685302 0.932725871526361 0.348837209302326 8.2 8 2 abnormal epidermal layer morphology 0.102588903683001 0.38259355009215 0.93002231827556 0.347826086956522 8.2 8 2 blistering 0.273072489125333 0.596634006762639 0.93002231827556 0.347826086956522 8.2 8 2 abnormal cardiovascular development 0.273072489125333 0.596634006762639 0.93002231827556 0.347826086956522 8.2 8 2 abnormal sacral vertebrae morphology 0.273072489125333 0.596634006762639 0.93002231827556 0.347826086956522 8.2 8 2 abnormal crista ampullaris morphology 0.273072489125333 0.596634006762639 0.93002231827556 0.347826086956522 8.2 8 2 increased circulating glucose level 0.0296442101300376 0.178684867687274 0.929197830404748 0.347517730496454 8.2 8 2 organ of Corti degeneration 0.154825106941652 0.488430505411996 0.927649812361592 0.346938775510204 8.2 8 2 increased fluid intake 0.154825106941652 0.488430505411996 0.927649812361592 0.346938775510204 8.2 8 2 abnormal hair growth 0.148646397094286 0.484293271476143 0.925551057130005 0.346153846153846 8.2 8 2 increased percent body fat/body weight 0.148646397094286 0.484293271476143 0.925551057130005 0.346153846153846 8.2 8 2 decreased body temperature 0.148646397094286 0.484293271476143 0.925551057130005 0.346153846153846 8.2 8 2 abnormal xiphoid process morphology 0.258893482127153 0.596029250761023 0.925551057130005 0.346153846153846 8.2 8 2 abnormal cardiovascular system physiology 0.0370487976030841 0.212103300431926 0.924777831518367 0.345864661654135 8.2 8 2 abnormal dendritic cell physiology 0.0567837124814333 0.278873612630929 0.924589944921147 0.345794392523364 8.2 8 2 abnormal skeleton development 0.0886455688445179 0.341296361897242 0.924281439767686 0.345679012345679 8.2 8 2 abnormal platelet physiology 0.142776050550543 0.480589209397127 0.92368125701459 0.345454545454545 8.2 8 2 abnormal parietal bone morphology 0.245941892212655 0.596029250761023 0.922004884497322 0.344827586206897 8.2 8 2 deafness 0.0715410852635636 0.29580563413186 0.918279612236727 0.343434343434343 8.2 8 2 rib fusion 0.121982936870872 0.426468805996199 0.917876504417484 0.343283582089552 8.2 8 2 increased circulating HDL cholesterol level 0.0666809527638556 0.29580563413186 0.916736285157338 0.342857142857143 8.2 8 2 dehydration 0.117373360793313 0.410641680693905 0.916736285157338 0.342857142857143 8.2 8 2 decreased total retina thickness 0.212762348641829 0.572777426673755 0.91472589856708 0.342105263157895 8.2 8 2 decreased sensitivity to induced morbidity/mortality 0.194259031555669 0.559906789963348 0.911527556264398 0.340909090909091 8.2 8 2 decreased circulating alkaline phosphatase level 0.177960078133782 0.530230787980701 0.90909681611436 0.34 8.2 8 2 abnormal renal glomerulus morphology 0.0726925388595278 0.29580563413186 0.907624991803328 0.339449541284404 8.2 8 2 short mandible 0.163470454702724 0.51245463903343 0.907186948853616 0.339285714285714 8.2 8 2 abnormal skeleton morphology 0.0677121655536571 0.29580563413186 0.906771760318671 0.339130434782609 8.2 8 2 pericardial effusion 0.150497287783733 0.48793723546778 0.905646733320757 0.338709677419355 8.2 8 2 decreased birth weight 0.0981840626412117 0.366991518888075 0.900653192435279 0.336842105263158 8.2 8 2 decreased osteoclast cell number 0.222073970749326 0.596029250761023 0.891271388347412 0.333333333333333 8.2 8 2 liver hemorrhage 0.284834797114402 0.601397602461656 0.891271388347412 0.333333333333333 8.2 8 2 abnormal enteric neuron morphology 0.388535065783917 0.734687173042564 0.891271388347412 0.333333333333333 8.2 8 2 abnormal epidermis stratum spinosum morphology 0.388535065783917 0.734687173042564 0.891271388347412 0.333333333333333 8.2 8 2 no suckling reflex 0.388535065783917 0.734687173042564 0.891271388347412 0.333333333333333 8.2 8 2 abnormal apical ectodermal ridge morphology 0.388535065783917 0.734687173042564 0.891271388347412 0.333333333333333 8.2 8 2 placental labyrinth hypoplasia 0.388535065783917 0.734687173042564 0.891271388347412 0.333333333333333 8.2 8 2 abnormal cricoid cartilage morphology 0.388535065783917 0.734687173042564 0.891271388347412 0.333333333333333 8.2 8 2 altered righting response 0.388535065783917 0.734687173042564 0.891271388347412 0.333333333333333 8.2 8 2 increased alcohol consumption 0.388535065783917 0.734687173042564 0.891271388347412 0.333333333333333 8.2 8 2 abnormal pericyte morphology 0.388535065783917 0.734687173042564 0.891271388347412 0.333333333333333 8.2 8 2 decreased thymocyte apoptosis 0.388535065783917 0.734687173042564 0.891271388347412 0.333333333333333 8.2 8 2 abnormal aorta wall morphology 0.388535065783917 0.734687173042564 0.891271388347412 0.333333333333333 8.2 8 2 liver vascular congestion 0.388535065783917 0.734687173042564 0.891271388347412 0.333333333333333 8.2 8 2 abnormal microglial cell activation 0.388535065783917 0.734687173042564 0.891271388347412 0.333333333333333 8.2 8 2 decreased trabecular bone mass 0.388535065783917 0.734687173042564 0.891271388347412 0.333333333333333 8.2 8 2 herniated liver 0.388535065783917 0.734687173042564 0.891271388347412 0.333333333333333 8.2 8 2 abnormal branching involved in lung morphogenesis 0.388535065783917 0.734687173042564 0.891271388347412 0.333333333333333 8.2 8 2 decreased brown adipose tissue mass 0.388535065783917 0.734687173042564 0.891271388347412 0.333333333333333 8.2 8 2 increased B cell number 0.085046469030014 0.331587918044138 0.891271388347412 0.333333333333333 8.2 8 2 increased lymphocyte cell number 0.156929126836799 0.493815563575631 0.891271388347412 0.333333333333333 8.2 8 2 abnormal cochlea morphology 0.19393856366315 0.559906789963348 0.891271388347412 0.333333333333333 8.2 8 2 abnormal mandible morphology 0.19393856366315 0.559906789963348 0.891271388347412 0.333333333333333 8.2 8 2 abnormal osteoblast physiology 0.19393856366315 0.559906789963348 0.891271388347412 0.333333333333333 8.2 8 2 impaired hematopoiesis 0.202724819818553 0.564692991318933 0.891271388347412 0.333333333333333 8.2 8 2 head tossing 0.270149762569443 0.596029250761023 0.891271388347412 0.333333333333333 8.2 8 2 cardiovascular system phenotype 0.270149762569443 0.596029250761023 0.891271388347412 0.333333333333333 8.2 8 2 wrinkled skin 0.300972399977742 0.603278682469488 0.891271388347412 0.333333333333333 8.2 8 2 abnormal palate morphology 0.300972399977742 0.603278682469488 0.891271388347412 0.333333333333333 8.2 8 2 abnormal bone trabecula morphology 0.300972399977742 0.603278682469488 0.891271388347412 0.333333333333333 8.2 8 2 trunk curl 0.338954030325703 0.665468153461078 0.891271388347412 0.333333333333333 8.2 8 2 abnormal hematopoietic system physiology 0.338954030325703 0.665468153461078 0.891271388347412 0.333333333333333 8.2 8 2 increased vasoconstriction 0.338954030325703 0.665468153461078 0.891271388347412 0.333333333333333 8.2 8 2 abnormal erythrocyte physiology 0.338954030325703 0.665468153461078 0.891271388347412 0.333333333333333 8.2 8 2 decreased cochlear outer hair cell number 0.338954030325703 0.665468153461078 0.891271388347412 0.333333333333333 8.2 8 2 abnormal heart left ventricle morphology 0.150661559219066 0.48793723546778 0.891271388347412 0.333333333333333 8.2 8 2 impaired wound healing 0.256688803680041 0.596029250761023 0.891271388347412 0.333333333333333 8.2 8 2 abnormal limb bone morphology 0.256688803680041 0.596029250761023 0.891271388347412 0.333333333333333 8.2 8 2 abnormal digestive system morphology 0.318869493224657 0.63328372406893 0.891271388347412 0.333333333333333 8.2 8 2 abnormal vasodilation 0.318869493224657 0.63328372406893 0.891271388347412 0.333333333333333 8.2 8 2 decreased ovulation rate 0.318869493224657 0.63328372406893 0.891271388347412 0.333333333333333 8.2 8 2 increased circulating total protein level 0.318869493224657 0.63328372406893 0.891271388347412 0.333333333333333 8.2 8 2 abnormal truncus arteriosus septation 0.318869493224657 0.63328372406893 0.891271388347412 0.333333333333333 8.2 8 2 abnormal mitral valve morphology 0.361851615515088 0.703482527232343 0.891271388347412 0.333333333333333 8.2 8 2 abnormal white adipose tissue morphology 0.361851615515088 0.703482527232343 0.891271388347412 0.333333333333333 8.2 8 2 abnormal metacarpal bone morphology 0.361851615515088 0.703482527232343 0.891271388347412 0.333333333333333 8.2 8 2 decreased activity of thyroid 0.361851615515088 0.703482527232343 0.891271388347412 0.333333333333333 8.2 8 2 abnormal glycogen homeostasis 0.361851615515088 0.703482527232343 0.891271388347412 0.333333333333333 8.2 8 2 abnormal macrophage chemotaxis 0.361851615515088 0.703482527232343 0.891271388347412 0.333333333333333 8.2 8 2 improved glucose tolerance 0.0382937572596777 0.212458872349148 0.886724085345639 0.331632653061224 8.2 8 2 increased liver weight 0.138341270542345 0.465976859138908 0.881143304388918 0.329545454545455 8.2 8 2 internal hemorrhage 0.183848710706123 0.53519446211993 0.877968830312376 0.328358208955224 8.2 8 2 abnormal enzyme/coenzyme level 0.209286588021079 0.564692991318933 0.875904640272456 0.327586206896552 8.2 8 2 abnormal T cell differentiation 0.131823542301209 0.445531333524806 0.873622449964295 0.326732673267327 8.2 8 2 decreased urine osmolality 0.239843239848291 0.596029250761023 0.873082176340322 0.326530612244898 8.2 8 2 delayed wound healing 0.251463418416689 0.596029250761023 0.871895923383338 0.326086956521739 8.2 8 2 abnormal lymphocyte physiology 0.251463418416689 0.596029250761023 0.871895923383338 0.326086956521739 8.2 8 2 kidney failure 0.263947219774049 0.596029250761023 0.870544146757937 0.325581395348837 8.2 8 2 abnormal lipid level 0.166884111650957 0.522826483289365 0.869794969351089 0.325301204819277 8.2 8 2 skin inflammation 0.291992768575671 0.601397602461656 0.86718297244613 0.324324324324324 8.2 8 2 decreased IgG level 0.130182471935356 0.440883456690535 0.86718297244613 0.324324324324324 8.2 8 2 overexpanded pulmonary alveoli 0.307872825442578 0.613648760647767 0.865057523984253 0.323529411764706 8.2 8 2 abnormal skin physiology 0.307872825442578 0.613648760647767 0.865057523984253 0.323529411764706 8.2 8 2 osteopetrosis 0.325275497277349 0.642615141952559 0.862520698400721 0.32258064516129 8.2 8 2 decreased neuronal precursor cell number 0.325275497277349 0.642615141952559 0.862520698400721 0.32258064516129 8.2 8 2 decreased double-negative T cell number 0.325275497277349 0.642615141952559 0.862520698400721 0.32258064516129 8.2 8 2 syndactyly 0.234213122398835 0.596029250761023 0.861058798911906 0.322033898305085 8.2 8 2 abnormal stria vascularis morphology 0.344495299306922 0.675547541999186 0.859440267335004 0.321428571428571 8.2 8 2 reddish skin 0.344495299306922 0.675547541999186 0.859440267335004 0.321428571428571 8.2 8 2 increased circulating luteinizing hormone level 0.344495299306922 0.675547541999186 0.859440267335004 0.321428571428571 8.2 8 2 enlarged kidney 0.256608062745423 0.596029250761023 0.857638505768264 0.320754716981132 8.2 8 2 increased pre-B cell number 0.365928120154246 0.70992228586616 0.855620532813515 0.32 8.2 8 2 abnormal vertebrae development 0.365928120154246 0.70992228586616 0.855620532813515 0.32 8.2 8 2 impaired conditioned place preference behavior 0.365928120154246 0.70992228586616 0.855620532813515 0.32 8.2 8 2 abnormal stomach mucosa morphology 0.365928120154246 0.70992228586616 0.855620532813515 0.32 8.2 8 2 abnormal skin morphology 0.238189517119731 0.596029250761023 0.850759052513438 0.318181818181818 8.2 8 2 renal interstitial fibrosis 0.29646837427596 0.601397602461656 0.850759052513438 0.318181818181818 8.2 8 2 abnormal photoreceptor outer segment morphology 0.29646837427596 0.601397602461656 0.850759052513438 0.318181818181818 8.2 8 2 abnormal basisphenoid bone morphology 0.390125126590708 0.735178979086656 0.850759052513438 0.318181818181818 8.2 8 2 intestinal ulcer 0.390125126590708 0.735178979086656 0.850759052513438 0.318181818181818 8.2 8 2 increased body size 0.390125126590708 0.735178979086656 0.850759052513438 0.318181818181818 8.2 8 2 intracerebral hemorrhage 0.390125126590708 0.735178979086656 0.850759052513438 0.318181818181818 8.2 8 2 abnormal chorion morphology 0.390125126590708 0.735178979086656 0.850759052513438 0.318181818181818 8.2 8 2 abnormal circulating lipid level 0.390125126590708 0.735178979086656 0.850759052513438 0.318181818181818 8.2 8 2 decreased susceptibility to viral infection induced morbidity/mortality 0.390125126590708 0.735178979086656 0.850759052513438 0.318181818181818 8.2 8 2 failure of palatal shelf elevation 0.390125126590708 0.735178979086656 0.850759052513438 0.318181818181818 8.2 8 2 impaired humoral immune response 0.390125126590708 0.735178979086656 0.850759052513438 0.318181818181818 8.2 8 2 increased neutrophil cell number 0.130383076745221 0.441206094901422 0.848244493737537 0.317241379310345 8.2 8 2 abnormal response/metabolism to endogenous compounds 0.212750878447468 0.572777426673755 0.847794735257294 0.317073170731707 8.2 8 2 short ulna 0.311862048783867 0.621351098397974 0.847794735257294 0.317073170731707 8.2 8 2 impaired natural killer cell mediated cytotoxicity 0.272457236760684 0.596337330789443 0.844362367908074 0.315789473684211 8.2 8 2 abnormal compact bone morphology 0.328560654698984 0.647105802504926 0.844362367908074 0.315789473684211 8.2 8 2 abnormal nail morphology 0.4178880487339 0.759916562302626 0.844362367908074 0.315789473684211 8.2 8 2 flaky skin 0.4178880487339 0.759916562302626 0.844362367908074 0.315789473684211 8.2 8 2 short vibrissae 0.4178880487339 0.759916562302626 0.844362367908074 0.315789473684211 8.2 8 2 delayed sexual maturation 0.4178880487339 0.759916562302626 0.844362367908074 0.315789473684211 8.2 8 2 abnormal ear morphology 0.4178880487339 0.759916562302626 0.844362367908074 0.315789473684211 8.2 8 2 decreased eye pigmentation 0.4178880487339 0.759916562302626 0.844362367908074 0.315789473684211 8.2 8 2 abnormal behavioral response to xenobiotic 0.4178880487339 0.759916562302626 0.844362367908074 0.315789473684211 8.2 8 2 decreased liver glycogen level 0.4178880487339 0.759916562302626 0.844362367908074 0.315789473684211 8.2 8 2 thin interventricular septum 0.4178880487339 0.759916562302626 0.844362367908074 0.315789473684211 8.2 8 2 abnormal artery morphology 0.346770119290708 0.67974048206118 0.84034159472756 0.314285714285714 8.2 8 2 abnormal femur morphology 0.262997276569422 0.596029250761023 0.838061156207268 0.313432835820896 8.2 8 2 abnormal kidney physiology 0.31409245818678 0.625294109435467 0.835566926575698 0.3125 8.2 8 2 abnormal osteoclast morphology 0.31409245818678 0.625294109435467 0.835566926575698 0.3125 8.2 8 2 abnormal embryonic hematopoiesis 0.366751721386261 0.711063840177961 0.835566926575698 0.3125 8.2 8 2 failure of tooth eruption 0.450450598269999 0.759916562302626 0.835566926575698 0.3125 8.2 8 2 vasculature congestion 0.450450598269999 0.759916562302626 0.835566926575698 0.3125 8.2 8 2 decreased mast cell number 0.450450598269999 0.759916562302626 0.835566926575698 0.3125 8.2 8 2 delayed hair appearance 0.450450598269999 0.759916562302626 0.835566926575698 0.3125 8.2 8 2 mixed cellular infiltration to dermis 0.450450598269999 0.759916562302626 0.835566926575698 0.3125 8.2 8 2 poor circulation 0.450450598269999 0.759916562302626 0.835566926575698 0.3125 8.2 8 2 paternal imprinting 0.450450598269999 0.759916562302626 0.835566926575698 0.3125 8.2 8 2 decreased cochlear coiling 0.450450598269999 0.759916562302626 0.835566926575698 0.3125 8.2 8 2 abnormal pulmonary elastic fiber morphology 0.450450598269999 0.759916562302626 0.835566926575698 0.3125 8.2 8 2 large intestinal inflammation 0.450450598269999 0.759916562302626 0.835566926575698 0.3125 8.2 8 2 decreased aggression towards mice 0.450450598269999 0.759916562302626 0.835566926575698 0.3125 8.2 8 2 abnormal molar crown morphology 0.450450598269999 0.759916562302626 0.835566926575698 0.3125 8.2 8 2 abnormal wound healing 0.450450598269999 0.759916562302626 0.835566926575698 0.3125 8.2 8 2 decreased circulating growth hormone level 0.450450598269999 0.759916562302626 0.835566926575698 0.3125 8.2 8 2 decreased circulating prolactin level 0.450450598269999 0.759916562302626 0.835566926575698 0.3125 8.2 8 2 abnormal Langerhans cell physiology 0.450450598269999 0.759916562302626 0.835566926575698 0.3125 8.2 8 2 decreased creatinine clearance 0.450450598269999 0.759916562302626 0.835566926575698 0.3125 8.2 8 2 dilated respiratory conducting tubes 0.450450598269999 0.759916562302626 0.835566926575698 0.3125 8.2 8 2 embryonic lethality between somite formation and embryo turning, incomplete penetrance 0.450450598269999 0.759916562302626 0.835566926575698 0.3125 8.2 8 2 decreased adipocyte glucose uptake 0.450450598269999 0.759916562302626 0.835566926575698 0.3125 8.2 8 2 altered response to myocardial infarction 0.330065846836376 0.649556007915731 0.831853295790918 0.311111111111111 8.2 8 2 abnormal autopod morphology 0.330065846836376 0.649556007915731 0.831853295790918 0.311111111111111 8.2 8 2 abnormal leukocyte migration 0.330469982324563 0.650094172425742 0.822712050782226 0.307692307692308 8.2 8 2 increased vascular permeability 0.366020233818432 0.70992228586616 0.822712050782226 0.307692307692308 8.2 8 2 impaired macrophage chemotaxis 0.366020233818432 0.70992228586616 0.822712050782226 0.307692307692308 8.2 8 2 abnormal leukocyte cell number 0.41349907038851 0.756821175651989 0.822712050782226 0.307692307692308 8.2 8 2 small seminal vesicle 0.41349907038851 0.756821175651989 0.822712050782226 0.307692307692308 8.2 8 2 abnormal ocular fundus morphology 0.41349907038851 0.756821175651989 0.822712050782226 0.307692307692308 8.2 8 2 abnormal Mullerian duct morphology 0.41349907038851 0.756821175651989 0.822712050782226 0.307692307692308 8.2 8 2 decreased bone resorption 0.41349907038851 0.756821175651989 0.822712050782226 0.307692307692308 8.2 8 2 decreased monocyte cell number 0.301724736079336 0.604543118000281 0.822712050782226 0.307692307692308 8.2 8 2 abnormal blood homeostasis 0.230077966007251 0.596029250761023 0.820907857688406 0.307017543859649 8.2 8 2 short femur 0.267030972191265 0.596029250761023 0.820374800637958 0.306818181818182 8.2 8 2 increased eosinophil cell number 0.315505229476372 0.62785540665798 0.819394663480685 0.306451612903226 8.2 8 2 increased inflammatory response 0.267497894406832 0.596029250761023 0.816216955644472 0.305263157894737 8.2 8 2 abnormal retinal cone cell morphology 0.44133565548181 0.759916562302626 0.813769528491115 0.304347826086957 8.2 8 2 bidirectional circling 0.44133565548181 0.759916562302626 0.813769528491115 0.304347826086957 8.2 8 2 hypotension 0.44133565548181 0.759916562302626 0.813769528491115 0.304347826086957 8.2 8 2 abnormal postnatal growth 0.44133565548181 0.759916562302626 0.813769528491115 0.304347826086957 8.2 8 2 abnormal B cell morphology 0.44133565548181 0.759916562302626 0.813769528491115 0.304347826086957 8.2 8 2 abnormal hepatocyte physiology 0.44133565548181 0.759916562302626 0.813769528491115 0.304347826086957 8.2 8 2 decreased T cell proliferation 0.216077004029119 0.581386206081594 0.812984036668247 0.304054054054054 8.2 8 2 abnormal middle ear ossicle morphology 0.408752573045746 0.756821175651989 0.810246716679465 0.303030303030303 8.2 8 2 decreased sensitivity to xenobiotic induced morbidity/mortality 0.408752573045746 0.756821175651989 0.810246716679465 0.303030303030303 8.2 8 2 abnormal intestinal mucosa morphology 0.383440684222508 0.729769473606342 0.808362421989513 0.302325581395349 8.2 8 2 abnormal eye physiology 0.360082062638376 0.70168752903483 0.802144249512671 0.3 8.2 8 2 perinatal lethality 0.403996116945285 0.756821175651989 0.802144249512671 0.3 8.2 8 2 salivary gland inflammation 0.433419847664317 0.759916562302626 0.802144249512671 0.3 8.2 8 2 waved hair 0.473238945542781 0.762670474271246 0.802144249512671 0.3 8.2 8 2 brain inflammation 0.473238945542781 0.762670474271246 0.802144249512671 0.3 8.2 8 2 abnormal trachea morphology 0.473238945542781 0.762670474271246 0.802144249512671 0.3 8.2 8 2 abnormal lens epithelium morphology 0.473238945542781 0.762670474271246 0.802144249512671 0.3 8.2 8 2 dilated vasculature 0.473238945542781 0.762670474271246 0.802144249512671 0.3 8.2 8 2 kidney atrophy 0.473238945542781 0.762670474271246 0.802144249512671 0.3 8.2 8 2 abnormal induced retinal neovascularization 0.473238945542781 0.762670474271246 0.802144249512671 0.3 8.2 8 2 abnormal heart electrocardiography waveform feature 0.473238945542781 0.762670474271246 0.802144249512671 0.3 8.2 8 2 increased sensitivity to induced morbidity/mortality 0.229931778430741 0.596029250761023 0.799237929768059 0.298913043478261 8.2 8 2 decreased compact bone thickness 0.357583411451673 0.697091485882473 0.79815348210216 0.298507462686567 8.2 8 2 increased white adipose tissue amount 0.42634991452175 0.759916562302626 0.794917724742286 0.297297297297297 8.2 8 2 increased insulin secretion 0.42634991452175 0.759916562302626 0.794917724742286 0.297297297297297 8.2 8 2 polyphagia 0.394834741326589 0.743490854693331 0.792241234086588 0.296296296296296 8.2 8 2 abnormal atrioventricular cushion morphology 0.46087872108778 0.759916562302626 0.792241234086588 0.296296296296296 8.2 8 2 abnormal CD4-positive, alpha-beta T cell physiology 0.370209884445757 0.717488965764565 0.790846443181506 0.295774647887324 8.2 8 2 osteoporosis 0.419912943232351 0.759916562302626 0.789990548762479 0.295454545454545 8.2 8 2 abnormal gametogenesis 0.419912943232351 0.759916562302626 0.789990548762479 0.295454545454545 8.2 8 2 decreased macrophage cell number 0.419912943232351 0.759916562302626 0.789990548762479 0.295454545454545 8.2 8 2 increased osteoclast cell number 0.390477064752147 0.735563573321443 0.788994343782955 0.295081967213115 8.2 8 2 increased width of hypertrophic chondrocyte zone 0.450785801213733 0.759916562302626 0.786415930894775 0.294117647058824 8.2 8 2 decreased regulatory T cell number 0.450785801213733 0.759916562302626 0.786415930894775 0.294117647058824 8.2 8 2 decreased osteoblast cell number 0.450785801213733 0.759916562302626 0.786415930894775 0.294117647058824 8.2 8 2 decreased cytotoxic T cell cytolysis 0.450785801213733 0.759916562302626 0.786415930894775 0.294117647058824 8.2 8 2 increased susceptibility to viral infection induced morbidity/mortality 0.450785801213733 0.759916562302626 0.786415930894775 0.294117647058824 8.2 8 2 abnormal bone marrow cavity morphology 0.510535275483793 0.812766467043751 0.786415930894775 0.294117647058824 8.2 8 2 hydroureter 0.510535275483793 0.812766467043751 0.786415930894775 0.294117647058824 8.2 8 2 increased incidence of corneal inflammation 0.510535275483793 0.812766467043751 0.786415930894775 0.294117647058824 8.2 8 2 decreased vasoconstriction 0.510535275483793 0.812766467043751 0.786415930894775 0.294117647058824 8.2 8 2 abnormal testis development 0.510535275483793 0.812766467043751 0.786415930894775 0.294117647058824 8.2 8 2 increased regulatory T cell number 0.510535275483793 0.812766467043751 0.786415930894775 0.294117647058824 8.2 8 2 abnormal tendon morphology 0.510535275483793 0.812766467043751 0.786415930894775 0.294117647058824 8.2 8 2 abnormal circulating chemokine level 0.510535275483793 0.812766467043751 0.786415930894775 0.294117647058824 8.2 8 2 common atrium 0.510535275483793 0.812766467043751 0.786415930894775 0.294117647058824 8.2 8 2 decreased body fat mass 0.510535275483793 0.812766467043751 0.786415930894775 0.294117647058824 8.2 8 2 increased tumor growth/size 0.442120558943113 0.759916562302626 0.782579755622118 0.292682926829268 8.2 8 2 abnormal cholesterol homeostasis 0.442120558943113 0.759916562302626 0.782579755622118 0.292682926829268 8.2 8 2 abnormal intestinal epithelium morphology 0.434447816763148 0.759916562302626 0.779862464803985 0.291666666666667 8.2 8 2 abnormal hair shaft morphology 0.434447816763148 0.759916562302626 0.779862464803985 0.291666666666667 8.2 8 2 abnormal malleus morphology 0.491762898764167 0.78818312543548 0.779862464803985 0.291666666666667 8.2 8 2 abnormal osteoblast morphology 0.491762898764167 0.78818312543548 0.779862464803985 0.291666666666667 8.2 8 2 abnormal inner cell mass apoptosis 0.491762898764167 0.78818312543548 0.779862464803985 0.291666666666667 8.2 8 2 increased lung adenoma incidence 0.477660718277167 0.769298178513728 0.776268628560649 0.290322580645161 8.2 8 2 abnormal CD8-positive, alpha beta T cell morphology 0.477660718277167 0.769298178513728 0.776268628560649 0.290322580645161 8.2 8 2 increased B cell proliferation 0.440114869983449 0.759916562302626 0.77042103060539 0.288135593220339 8.2 8 2 abnormal cytokine secretion 0.382313376642113 0.727902429695566 0.763946904297782 0.285714285714286 8.2 8 2 abnormal respiratory system physiology 0.469487156957492 0.759916562302626 0.763946904297782 0.285714285714286 8.2 8 2 abnormal jaw morphology 0.507432089800123 0.811989272034613 0.763946904297782 0.285714285714286 8.2 8 2 abnormal trabecular bone morphology 0.403870473884426 0.756821175651989 0.763946904297781 0.285714285714286 8.2 8 2 small ears 0.526952911629612 0.82569786940388 0.763946904297781 0.285714285714286 8.2 8 2 hypoalgesia 0.526952911629612 0.82569786940388 0.763946904297781 0.285714285714286 8.2 8 2 dry skin 0.526952911629612 0.82569786940388 0.763946904297781 0.285714285714286 8.2 8 2 abnormal inner ear morphology 0.492639566123578 0.789333926397682 0.755643133598893 0.282608695652174 8.2 8 2 increased autoantibody level 0.505542384935575 0.809225664431945 0.754152713217041 0.282051282051282 8.2 8 2 decreased trabecular bone volume 0.505542384935575 0.809225664431945 0.754152713217041 0.282051282051282 8.2 8 2 abnormal lymphatic vessel morphology 0.521059890973609 0.817236115256527 0.752010233918129 0.28125 8.2 8 2 increased dopamine level 0.521059890973609 0.817236115256527 0.752010233918129 0.28125 8.2 8 2 ruffled hair 0.540698646001358 0.839044218295931 0.748667966211826 0.28 8.2 8 2 abnormal energy expenditure 0.540698646001358 0.839044218295931 0.748667966211826 0.28 8.2 8 2 decreased platelet aggregation 0.514887011118649 0.812766467043751 0.742726156956176 0.277777777777778 8.2 8 2 abnormal epidermis stratum granulosum morphology 0.533155987761227 0.834366479745865 0.742726156956176 0.277777777777778 8.2 8 2 abnormal Peyer's patch follicle morphology 0.567721298548679 0.874160773840817 0.742726156956176 0.277777777777778 8.2 8 2 abnormal redox activity 0.567721298548679 0.874160773840817 0.742726156956176 0.277777777777778 8.2 8 2 long tibia 0.567721298548679 0.874160773840817 0.742726156956176 0.277777777777778 8.2 8 2 abnormal neutrophil morphology 0.567721298548679 0.874160773840817 0.742726156956176 0.277777777777778 8.2 8 2 abnormal eye anterior chamber morphology 0.567721298548679 0.874160773840817 0.742726156956176 0.277777777777778 8.2 8 2 increased susceptibility to autoimmune disorder 0.567721298548679 0.874160773840817 0.742726156956176 0.277777777777778 8.2 8 2 decreased fluid intake 0.567721298548679 0.874160773840817 0.742726156956176 0.277777777777778 8.2 8 2 increased systemic arterial blood pressure 0.528311335034 0.827044962804956 0.739565620118065 0.276595744680851 8.2 8 2 abnormal T-helper 1 physiology 0.528311335034 0.827044962804956 0.739565620118065 0.276595744680851 8.2 8 2 decreased bone trabecula number 0.528311335034 0.827044962804956 0.739565620118065 0.276595744680851 8.2 8 2 abnormal humoral immune response 0.500412782732711 0.80153045527857 0.738482007487856 0.276190476190476 8.2 8 2 abnormal middle ear morphology 0.552608378295659 0.856456910286886 0.737603907597858 0.275862068965517 8.2 8 2 decreased circulating phosphate level 0.544059934862927 0.843733845368784 0.735298895386615 0.275 8.2 8 2 increased susceptibility to weight loss 0.544059934862927 0.843733845368784 0.735298895386615 0.275 8.2 8 2 hypertension 0.554008906474609 0.857488165415691 0.729222045011519 0.272727272727273 8.2 8 2 abnormal T cell subpopulation ratio 0.563175135196557 0.869043516626201 0.729222045011519 0.272727272727273 8.2 8 2 increased activated T cell number 0.578263331019201 0.878611218344464 0.729222045011519 0.272727272727273 8.2 8 2 abnormal cochlear sensory epithelium morphology 0.578263331019201 0.878611218344464 0.729222045011519 0.272727272727273 8.2 8 2 abnormal colon morphology 0.556356821656854 0.858788454155398 0.725102146452132 0.271186440677966 8.2 8 2 abnormal urine homeostasis 0.550776283112326 0.853883455432789 0.724158003032272 0.270833333333333 8.2 8 2 abnormal humerus morphology 0.572713792664737 0.878611218344464 0.722652477038442 0.27027027027027 8.2 8 2 decreased Peyer's patch number 0.587561647542934 0.878611218344464 0.719873044434448 0.269230769230769 8.2 8 2 emphysema 0.595949662161601 0.878611218344464 0.713017110677929 0.266666666666667 8.2 8 2 lung inflammation 0.610112393507222 0.878611218344464 0.707774337805298 0.264705882352941 8.2 8 2 decreased pancreatic beta cell number 0.603635295430374 0.878611218344464 0.707774337805298 0.264705882352941 8.2 8 2 increased susceptibility to bacterial infection induced morbidity/mortality 0.607248524410051 0.878611218344464 0.705589849108368 0.263888888888889 8.2 8 2 decreased susceptibility to induced arthritis 0.610685777859762 0.878611218344464 0.703635306590062 0.263157894736842 8.2 8 2 abnormal triglyceride level 0.62123317348253 0.884554962242583 0.703635306590062 0.263157894736842 8.2 8 2 decreased chemically-elicited antinociception 0.62123317348253 0.884554962242583 0.703635306590062 0.263157894736842 8.2 8 2 abnormal cochlear inner hair cell morphology 0.62123317348253 0.884554962242583 0.703635306590062 0.263157894736842 8.2 8 2 abnormal blastocyst morphology 0.62123317348253 0.884554962242583 0.703635306590062 0.263157894736842 8.2 8 2 abnormal NK cell physiology 0.616973995017937 0.879749391004367 0.701328305584849 0.262295081967213 8.2 8 2 abnormal vibrissa morphology 0.617416514818351 0.88012812642444 0.700284662272966 0.261904761904762 8.2 8 2 decreased inflammatory response 0.624728331234077 0.889277095247363 0.700284662272966 0.261904761904762 8.2 8 2 abnormal blood vessel physiology 0.62659074591475 0.890908534131433 0.69751673870667 0.260869565217391 8.2 8 2 pancreas inflammation 0.62659074591475 0.890908534131433 0.69751673870667 0.260869565217391 8.2 8 2 abnormal cochlear ganglion morphology 0.62659074591475 0.890908534131433 0.69751673870667 0.260869565217391 8.2 8 2 abnormal vertebral artery topology 0.62659074591475 0.890908534131433 0.69751673870667 0.260869565217391 8.2 8 2 decreased bone ossification 0.631900671802238 0.898201669204609 0.693211079825765 0.259259259259259 8.2 8 2 abnormal intestine physiology 0.637093642643144 0.905324442202125 0.690016558720577 0.258064516129032 8.2 8 2 decreased bone mineralization 0.642142564392947 0.912238508810654 0.687552213868003 0.257142857142857 8.2 8 2 abnormal leukocyte adhesion 0.647039260400482 0.918932435196231 0.685593375651855 0.256410256410256 8.2 8 2 impaired macrophage phagocytosis 0.651784376740474 0.925407327135804 0.683998972452665 0.255813953488372 8.2 8 2 abnormal spleen germinal center morphology 0.673390199136276 0.94902421294035 0.668453541260559 0.25 8.2 8 2 decreased IgA level 0.690558769219192 0.95857418439327 0.668453541260559 0.25 8.2 8 2 abnormal hair texture 0.670564582795779 0.948886235857603 0.668453541260559 0.25 8.2 8 2 abnormal Peyer's patch T cell area morphology 0.670564582795779 0.948886235857603 0.668453541260559 0.25 8.2 8 2 abnormal hyoid bone morphology 0.670564582795779 0.948886235857603 0.668453541260559 0.25 8.2 8 2 abnormal adrenal gland morphology 0.671533361631612 0.94902421294035 0.668453541260559 0.25 8.2 8 2 abnormal systemic arterial blood pressure 0.678471423270187 0.952181182007597 0.668453541260559 0.25 8.2 8 2 abnormal inflammatory response 0.705953833633591 0.968924923778213 0.668453541260559 0.25 8.2 8 2 abnormal long bone morphology 0.722803586695392 0.973192921193389 0.657495286485796 0.245901639344262 8.2 8 2 abnormal T cell activation 0.751765368940328 1 0.650387229334598 0.243243243243243 8.2 8 2 decreased systemic arterial blood pressure 0.711802415760646 0.968924923778213 0.648197373343572 0.242424242424242 8.2 8 2 abnormal circulating glucose level 0.711820778494653 0.968924923778213 0.645403419148126 0.241379310344828 8.2 8 2 glomerulosclerosis 0.74616585695331 1 0.645403419148126 0.241379310344828 8.2 8 2 abnormal thyroid gland morphology 0.712849587620113 0.968924923778213 0.641715399610136 0.24 8.2 8 2 abnormal feces composition 0.712849587620113 0.968924923778213 0.641715399610136 0.24 8.2 8 2 abnormal cochlear outer hair cell morphology 0.712849587620113 0.968924923778213 0.641715399610136 0.24 8.2 8 2 increased acute inflammation 0.715443230035206 0.968924923778213 0.636622420248151 0.238095238095238 8.2 8 2 abnormal stapes morphology 0.715443230035206 0.968924923778213 0.636622420248151 0.238095238095238 8.2 8 2 abnormal T-helper 2 physiology 0.769875246379282 1 0.631992439009983 0.236363636363636 8.2 8 2 abnormal immune system physiology 0.856367214962606 1 0.625327506340523 0.233870967741935 8.2 8 2 abnormal pain threshold 0.747085900856886 1 0.623889971843188 0.233333333333333 8.2 8 2 abnormal spleen marginal zone morphology 0.747085900856886 1 0.623889971843188 0.233333333333333 8.2 8 2 abnormal lens fiber morphology 0.773126141912318 1 0.61703403808667 0.230769230769231 8.2 8 2 abnormal tectorial membrane morphology 0.750435969643267 1 0.61703403808667 0.230769230769231 8.2 8 2 abnormal lymph node morphology 0.795194035647717 1 0.612749079488845 0.229166666666667 8.2 8 2 decreased bone volume 0.77558595247996 1 0.611157523438225 0.228571428571429 8.2 8 2 abnormal mesenteric lymph node morphology 0.755790259157561 1 0.607685037509599 0.227272727272727 8.2 8 2 abnormal temporal bone morphology 0.755790259157561 1 0.607685037509599 0.227272727272727 8.2 8 2 abnormal body temperature homeostasis 0.779166976169228 1 0.603764488880505 0.225806451612903 8.2 8 2 decreased susceptibility to injury 0.864046807513645 1 0.589811948171081 0.220588235294118 8.2 8 2 fragile skeleton 0.79167901283612 1 0.581263948922225 0.217391304347826 8.2 8 2 abnormal immune system morphology 0.841891335855495 1 0.581263948922225 0.217391304347826 8.2 8 2 abnormal Wolffian duct morphology 0.79167901283612 1 0.581263948922225 0.217391304347826 8.2 8 2 abnormal regulatory T cell physiology 0.79167901283612 1 0.581263948922225 0.217391304347826 8.2 8 2 abnormal aorta morphology 0.834048728842263 1 0.567172701675626 0.212121212121212 8.2 8 2 absent vibrissae 0.834048728842263 1 0.567172701675626 0.212121212121212 8.2 8 2 abnormal skeleton physiology 0.834048728842263 1 0.567172701675626 0.212121212121212 8.2 8 2 apnea 0.823296289468885 1 0.557044617717132 0.208333333333333 8.2 8 2 decreased fatty acid level 0.823296289468885 1 0.557044617717132 0.208333333333333 8.2 8 2 abnormal phalanx morphology 0.878551604011729 1 0.557044617717132 0.208333333333333 8.2 8 2 stomach inflammation 0.841351697704438 1 0.553202930698393 0.206896551724138 8.2 8 2 increased susceptibility to induced arthritis 0.841351697704438 1 0.553202930698393 0.206896551724138 8.2 8 2 decreased bone strength 0.841351697704438 1 0.553202930698393 0.206896551724138 8.2 8 2 abnormal cartilage development 0.898884135104385 1 0.534762833008447 0.2 8.2 8 2 gastrointestinal hemorrhage 0.864918146916326 1 0.534762833008447 0.2 8.2 8 2 abnormal digestive system physiology 0.907970926133984 1 0.534762833008447 0.2 8.2 8 2 autoimmune response 0.885498427895629 1 0.517512419040433 0.193548387096774 8.2 8 2 decreased susceptibility to bacterial infection induced morbidity/mortality 0.885498427895629 1 0.517512419040433 0.193548387096774 8.2 8 2 abnormal ureter morphology 0.874829868571033 1 0.514195031738891 0.192307692307692 8.2 8 2 no spontaneous movement 0.874829868571033 1 0.514195031738891 0.192307692307692 8.2 8 2 abnormal crypts of Lieberkuhn morphology 0.903355520625226 1 0.501340155945419 0.1875 8.2 8 2 decreased susceptibility to parasitic infection 0.903355520625226 1 0.501340155945419 0.1875 8.2 8 2 decreased granulocyte number 0.927903306333427 1 0.461002442248661 0.172413793103448 8.2 8 2 increased double-positive T cell number 0.927903306333427 1 0.461002442248661 0.172413793103448 8.2 8 2 abnormal thrombosis 0.993363973082375 1 0.366994101084228 0.137254901960784 8.2 8 2 increased susceptibility to parasitic infection 0.999518668360321 1 0.356508555338965 0.133333333333333 8.2 8 2 impaired social transmission of food preference 8.60867457677232e-07 3.66052615550789e-05 3.03953322219576 1 8.1 8 1 abnormal hippocampus granule cell morphology 3.48030990906227e-06 0.000127312807335182 3.03953322219576 1 8.1 8 1 hyperresponsive 0.000229841821488422 0.00462940510892671 3.03953322219576 1 8.1 8 1 chromatolysis 0.000229841821488422 0.00462940510892671 3.03953322219576 1 8.1 8 1 optic nerve atrophy 0.000928869860963394 0.0149551053666436 3.03953322219576 1 8.1 8 1 gastric polyps 0.000928869860963394 0.0149551053666436 3.03953322219576 1 8.1 8 1 abnormal cerebellum lobule morphology 0.000928869860963394 0.0149551053666436 3.03953322219576 1 8.1 8 1 decreased synaptic depression 1.97580850243018e-06 7.56126715353088e-05 2.78623878701278 0.916666666666667 8.1 8 1 abnormal hippocampus neuron morphology 2.70552919715276e-05 0.000773563664128447 2.73557989997618 0.9 8.1 8 1 colon polyps 0.000356457765308094 0.00671733856972638 2.65959156942129 0.875 8.1 8 1 abnormal gastrulation movements 0.00126768762642623 0.0193458464462285 2.60531419045351 0.857142857142857 8.1 8 1 abnormal Purkinje cell innervation 0.00126768762642623 0.0193458464462285 2.60531419045351 0.857142857142857 8.1 8 1 axonal dystrophy 9.93719182544033e-06 0.000321022917737439 2.57191272647334 0.846153846153846 8.1 8 1 abnormal respiratory function 3.41630320658446e-05 0.000939011516726943 2.5329443518298 0.833333333333333 8.1 8 1 abnormal vascular endothelial cell development 3.41630320658446e-05 0.000939011516726943 2.5329443518298 0.833333333333333 8.1 8 1 abnormal hippocampal fimbria morphology 0.00442401005833826 0.0511847675354252 2.5329443518298 0.833333333333333 8.1 8 1 phenotypic reversion 0.00442401005833826 0.0511847675354252 2.5329443518298 0.833333333333333 8.1 8 1 abnormal olfactory bulb layer morphology 0.00442401005833826 0.0511847675354252 2.5329443518298 0.833333333333333 8.1 8 1 ectopic hippocampus pyramidal cells 0.00442401005833826 0.0511847675354252 2.5329443518298 0.833333333333333 8.1 8 1 decreased hippocampus volume 0.00442401005833826 0.0511847675354252 2.5329443518298 0.833333333333333 8.1 8 1 absence seizures 9.97776053370078e-07 4.07829704784539e-05 2.50314500651416 0.823529411764706 8.1 8 1 abnormal eye distance/ position 0.000115772549909905 0.00264205704496228 2.48689081816017 0.818181818181818 8.1 8 1 testis degeneration 3.59040120624787e-05 0.000976079016452633 2.38820467458238 0.785714285714286 8.1 8 1 abnormal CNS synapse formation 0.00125833782127028 0.0193216995704311 2.36408139504115 0.777777777777778 8.1 8 1 abnormal object recognition memory 1.08563848205159e-09 8.30930992031797e-08 2.3531870107322 0.774193548387097 8.1 8 1 abnormal channel response 3.40059995881021e-07 1.61123664715055e-05 2.34873021715127 0.772727272727273 8.1 8 1 abnormal synaptic transmission 3.41537323240367e-09 2.29614619340652e-07 2.33030880368342 0.766666666666667 8.1 8 1 increased brain size 1.09467425947549e-05 0.000349102848775037 2.32434893462029 0.764705882352941 8.1 8 1 increased mammary adenocarcinoma incidence 3.31442395134309e-06 0.000122142660429125 2.27964991664682 0.75 8.1 8 1 decreased aerobic running capacity 0.00400137720978064 0.0477382532821551 2.27964991664682 0.75 8.1 8 1 tau protein deposits 0.00400137720978064 0.0477382532821551 2.27964991664682 0.75 8.1 8 1 craniofacial phenotype 0.00400137720978064 0.0477382532821551 2.27964991664682 0.75 8.1 8 1 increased pulmonary ventilation 0.00400137720978064 0.0477382532821551 2.27964991664682 0.75 8.1 8 1 abnormal olfactory bulb mitral cell layer morphology 0.00400137720978064 0.0477382532821551 2.27964991664682 0.75 8.1 8 1 decreased hippocampus pyramidal cell number 0.00400137720978064 0.0477382532821551 2.27964991664682 0.75 8.1 8 1 abnormal cerebellum deep nucleus morphology 0.00400137720978064 0.0477382532821551 2.27964991664682 0.75 8.1 8 1 pleural effusion 0.00400137720978064 0.0477382532821551 2.27964991664682 0.75 8.1 8 1 abnormal heart echocardiography feature 0.00400137720978064 0.0477382532821551 2.27964991664682 0.75 8.1 8 1 abnormal proximal-distal axis patterning 0.00110538765550429 0.0173479608395389 2.21056961614237 0.727272727272727 8.1 8 1 abnormal extraembryonic ectoderm morphology 0.00110538765550429 0.0173479608395389 2.21056961614237 0.727272727272727 8.1 8 1 abnormal CNS synaptic transmission 1.36190180512569e-23 5.2118934465387e-21 2.21056961614237 0.727272727272727 8.1 8 1 midline facial cleft 0.000312445384878975 0.00600160536591854 2.17109515871126 0.714285714285714 8.1 8 1 abnormal renal tubule epithelial cell primary cilium morphology 0.000312445384878975 0.00600160536591854 2.17109515871126 0.714285714285714 8.1 8 1 broad head 0.0123148161381183 0.113666438380591 2.17109515871126 0.714285714285714 8.1 8 1 abnormal inhibitory postsynaptic potential 0.0123148161381183 0.113666438380591 2.17109515871126 0.714285714285714 8.1 8 1 abnormal tricarboxylic acid cycle 0.0123148161381183 0.113666438380591 2.17109515871126 0.714285714285714 8.1 8 1 embryonic lethality at implantation, incomplete penetrance 0.0123148161381183 0.113666438380591 2.17109515871126 0.714285714285714 8.1 8 1 embryo tumor 0.0123148161381183 0.113666438380591 2.17109515871126 0.714285714285714 8.1 8 1 abnormal embryonic-extraembryonic boundary morphology 8.96714698282372e-05 0.00212435982093086 2.14555286272642 0.705882352941177 8.1 8 1 abnormal grooming behavior 0.00329456838724808 0.042352655624184 2.12767325553703 0.7 8.1 8 1 absent trophoblast giant cells 0.00329456838724808 0.042352655624184 2.12767325553703 0.7 8.1 8 1 increased heart rate variability 0.00329456838724808 0.042352655624184 2.12767325553703 0.7 8.1 8 1 lethality during fetal growth through weaning, complete penetrance 0.00329456838724808 0.042352655624184 2.12767325553703 0.7 8.1 8 1 abnormal brain wave pattern 1.81504657442626e-11 1.96301232777622e-09 2.10429223075091 0.692307692307692 8.1 8 1 increased synaptic depression 0.000913392962235599 0.0148682887397988 2.10429223075091 0.692307692307692 8.1 8 1 impaired somite development 0.000258767936802395 0.00512896607805544 2.08967909025959 0.6875 8.1 8 1 increased liver adenoma incidence 7.43834336247412e-05 0.00180192391357042 2.07968062571289 0.684210526315789 8.1 8 1 abnormal cerebral cortex pyramidal cell morphology 2.16059357788931e-05 0.000639818633928532 2.07240901513347 0.681818181818182 8.1 8 1 impaired synaptic plasticity 1.6385392847326e-07 8.31809483831092e-06 2.05615482677949 0.676470588235294 8.1 8 1 failure to gastrulate 1.31372702114633e-09 9.61145872088678e-08 2.04838108452323 0.673913043478261 8.1 8 1 impaired balance 5.03339210507216e-19 1.391173651263e-16 2.02635548146384 0.666666666666667 8.1 8 1 enhanced paired-pulse facilitation 1.52319590924264e-06 6.00125431318313e-05 2.02635548146384 0.666666666666667 8.1 8 1 increased osteosarcoma incidence 0.00259496075962869 0.0346110717939752 2.02635548146384 0.666666666666667 8.1 8 1 decreased red blood cell distribution width 0.00259496075962869 0.0346110717939752 2.02635548146384 0.666666666666667 8.1 8 1 prenatal growth retardation 0.00259496075962869 0.0346110717939752 2.02635548146384 0.666666666666667 8.1 8 1 abnormal head movements 0.00948745598680138 0.0940240907058504 2.02635548146384 0.666666666666667 8.1 8 1 increased pheochromocytoma incidence 0.00948745598680138 0.0940240907058504 2.02635548146384 0.666666666666667 8.1 8 1 abnormal NMDA-mediated synaptic currents 0.00948745598680138 0.0940240907058504 2.02635548146384 0.666666666666667 8.1 8 1 premature neuronal precursor differentiation 0.00948745598680138 0.0940240907058504 2.02635548146384 0.666666666666667 8.1 8 1 decreased fear-related response 0.00948745598680138 0.0940240907058504 2.02635548146384 0.666666666666667 8.1 8 1 decreased muscle weight 0.00948745598680138 0.0940240907058504 2.02635548146384 0.666666666666667 8.1 8 1 increased tidal volume 0.00948745598680138 0.0940240907058504 2.02635548146384 0.666666666666667 8.1 8 1 abnormal cerebellar layer morphology 0.00948745598680138 0.0940240907058504 2.02635548146384 0.666666666666667 8.1 8 1 retropulsion 0.00948745598680138 0.0940240907058504 2.02635548146384 0.666666666666667 8.1 8 1 abnormal ventricle myocardium morphology 0.00948745598680138 0.0940240907058504 2.02635548146384 0.666666666666667 8.1 8 1 reduced AMPA-mediated synaptic currents 0.00948745598680138 0.0940240907058504 2.02635548146384 0.666666666666667 8.1 8 1 cerebellum atrophy 0.00948745598680138 0.0940240907058504 2.02635548146384 0.666666666666667 8.1 8 1 absent long term depression 4.14383049623044e-06 0.000147253976562475 1.99141831799033 0.655172413793103 8.1 8 1 abnormal excitatory postsynaptic currents 4.1180919735498e-14 6.82916918947009e-12 1.98738710682031 0.653846153846154 8.1 8 1 abnormal ectoplacental cone morphology 0.000568778126255016 0.0101786733025853 1.96675679083255 0.647058823529412 8.1 8 1 myoclonus 1.1088533718982e-05 0.00035137232644545 1.95398564284013 0.642857142857143 8.1 8 1 abnormal placing response 0.00199509860147752 0.0282943439962564 1.95398564284013 0.642857142857143 8.1 8 1 abnormal primitive streak morphology 3.75331350907184e-05 0.00100933701122337 1.94530126220529 0.64 8.1 8 1 abnormal egg cylinder morphology 3.75331350907184e-05 0.00100933701122337 1.94530126220529 0.64 8.1 8 1 abnormal motor coordination/ balance 3.11913777255658e-16 6.46571267436207e-14 1.93424841412458 0.636363636363636 8.1 8 1 social withdrawal 0.00712563466779971 0.0759101337736693 1.93424841412458 0.636363636363636 8.1 8 1 abnormal fear/anxiety-related behavior 0.00712563466779971 0.0759101337736693 1.93424841412458 0.636363636363636 8.1 8 1 fatigue 0.00712563466779971 0.0759101337736693 1.93424841412458 0.636363636363636 8.1 8 1 abnormal spinal cord ventral horn morphology 0.00712563466779971 0.0759101337736693 1.93424841412458 0.636363636363636 8.1 8 1 common atrioventricular valve 0.00712563466779971 0.0759101337736693 1.93424841412458 0.636363636363636 8.1 8 1 increased malignant tumor incidence 0.00043754544588965 0.00806217997518892 1.91970519296574 0.631578947368421 8.1 8 1 abnormal nervous system electrophysiology 1.15941556757155e-13 1.64802641390527e-11 1.91780072352828 0.630952380952381 8.1 8 1 abnormal dendritic spine morphology 1.0295668799573e-08 6.1711990696236e-07 1.90715810020126 0.627450980392157 8.1 8 1 ocular hypertelorism 9.83291437333174e-05 0.0023074881607229 1.89970826387235 0.625 8.1 8 1 reduced male mating frequency 0.00151196601786577 0.0227251689996441 1.89970826387235 0.625 8.1 8 1 failure of vascular branching 0.0261705476853478 0.189241969090996 1.89970826387235 0.625 8.1 8 1 early eyelid opening 0.0261705476853478 0.189241969090996 1.89970826387235 0.625 8.1 8 1 hypergranulosis 0.0261705476853478 0.189241969090996 1.89970826387235 0.625 8.1 8 1 abnormal olfactory bulb glomerular layer morphology 0.0261705476853478 0.189241969090996 1.89970826387235 0.625 8.1 8 1 anomalous pulmonary venous connection 0.0261705476853478 0.189241969090996 1.89970826387235 0.625 8.1 8 1 myocardial trabeculae hypoplasia 0.0261705476853478 0.189241969090996 1.89970826387235 0.625 8.1 8 1 abnormal anterior commissure pars posterior morphology 0.0261705476853478 0.189241969090996 1.89970826387235 0.625 8.1 8 1 decreased cranium length 0.0261705476853478 0.189241969090996 1.89970826387235 0.625 8.1 8 1 abnormal umbilical vein topology 0.0261705476853478 0.189241969090996 1.89970826387235 0.625 8.1 8 1 increased brain apoptosis 0.0261705476853478 0.189241969090996 1.89970826387235 0.625 8.1 8 1 abnormal embryonic/fetal subventricular zone morphology 0.000333229646487206 0.00635179115430594 1.88161580421642 0.619047619047619 8.1 8 1 abnormal endoderm development 5.18458493819245e-06 0.000177884897017293 1.87735875488562 0.617647058823529 8.1 8 1 short premaxilla 0.00528546923545764 0.0596027071407734 1.8704819828897 0.615384615384615 8.1 8 1 excessive scratching 0.00528546923545764 0.0596027071407734 1.8704819828897 0.615384615384615 8.1 8 1 abnormal afterhyperpolarization 0.00528546923545764 0.0596027071407734 1.8704819828897 0.615384615384615 8.1 8 1 abnormal vertebral arch development 0.00528546923545764 0.0596027071407734 1.8704819828897 0.615384615384615 8.1 8 1 seizures 1.15528599411615e-16 2.61252173669446e-14 1.8663800487167 0.614035087719298 8.1 8 1 straub tail 5.7049179420742e-05 0.00144070897268118 1.84543088490457 0.607142857142857 8.1 8 1 abnormal axon guidance 7.08523488271481e-07 3.11938438420409e-05 1.83785729714162 0.604651162790698 8.1 8 1 abnormal hippocampus pyramidal cell morphology 9.93289587079293e-06 0.000321022917737439 1.82371993331746 0.6 8.1 8 1 abnormal nest building behavior 0.000189523156697216 0.00394509499819519 1.82371993331746 0.6 8.1 8 1 abnormal hearing physiology 0.000847552733501577 0.0139621683747362 1.82371993331746 0.6 8.1 8 1 decreased paired-pulse facilitation 0.000847552733501577 0.0139621683747362 1.82371993331746 0.6 8.1 8 1 spleen atrophy 0.000847552733501577 0.0139621683747362 1.82371993331746 0.6 8.1 8 1 increased cranium width 0.0187767873861313 0.146878171770445 1.82371993331746 0.6 8.1 8 1 enlarged testis 0.0187767873861313 0.146878171770445 1.82371993331746 0.6 8.1 8 1 abnormal PNS synaptic transmission 0.0187767873861313 0.146878171770445 1.82371993331746 0.6 8.1 8 1 abnormal plasma membrane morphology 0.0187767873861313 0.146878171770445 1.82371993331746 0.6 8.1 8 1 abnormal spinal cord dorsal column morphology 0.0187767873861313 0.146878171770445 1.82371993331746 0.6 8.1 8 1 abnormal cerebellar granule cell migration 0.0187767873861313 0.146878171770445 1.82371993331746 0.6 8.1 8 1 thin ventricle myocardium compact layer 0.0187767873861313 0.146878171770445 1.82371993331746 0.6 8.1 8 1 abnormal pup retrieval 0.00389467067789208 0.0477200616868018 1.82371993331746 0.6 8.1 8 1 delayed intramembranous bone ossification 0.00389467067789208 0.0477200616868018 1.82371993331746 0.6 8.1 8 1 abnormal placenta size 0.00389467067789208 0.0477200616868018 1.82371993331746 0.6 8.1 8 1 abnormal excitatory postsynaptic potential 1.75604604066288e-11 1.94140645606618e-09 1.81630643765356 0.597560975609756 8.1 8 1 increased cellular sensitivity to gamma-irradiation 4.10323809862512e-07 1.89014903154259e-05 1.81078574939322 0.595744680851064 8.1 8 1 abnormal auditory brainstem response waveform shape 3.24813110588589e-05 0.000902762695630296 1.80472285067873 0.59375 8.1 8 1 increased fibroblast apoptosis 3.24813110588589e-05 0.000902762695630296 1.80472285067873 0.59375 8.1 8 1 decreased susceptibility to pharmacologically induced seizures 0.000141991657675024 0.00312570131386391 1.8012048724123 0.592592592592593 8.1 8 1 abnormal single cell response 0.000141991657675024 0.00312570131386391 1.8012048724123 0.592592592592593 8.1 8 1 abnormal tail movements 0.000630074506370965 0.0108429164025384 1.79608781311568 0.590909090909091 8.1 8 1 increased coping response 0.000630074506370965 0.0108429164025384 1.79608781311568 0.590909090909091 8.1 8 1 increased mammary gland tumor incidence 0.000630074506370965 0.0108429164025384 1.79608781311568 0.590909090909091 8.1 8 1 ataxia 5.06797574985702e-25 2.29210721413988e-22 1.79061610614503 0.589108910891089 8.1 8 1 abnormal inhibitory postsynaptic currents 2.38305912066598e-09 1.64662765629351e-07 1.78796071893868 0.588235294117647 8.1 8 1 abnormal direction of heart looping 2.43920637524475e-05 0.000709652147183779 1.78796071893868 0.588235294117647 8.1 8 1 abnormal dorsal-ventral axis patterning 0.00285937729159539 0.0376333386922939 1.78796071893868 0.588235294117647 8.1 8 1 abnormal involuntary movement 0.00285937729159539 0.0376333386922939 1.78796071893868 0.588235294117647 8.1 8 1 embryonic lethality between implantation and placentation, complete penetrance 9.9849749200292e-07 4.07829704784539e-05 1.78407384781056 0.58695652173913 8.1 8 1 increased mortality induced by gamma-irradiation 0.000106061009421251 0.00245420242730569 1.78179533714924 0.586206896551724 8.1 8 1 abnormal action potential 1.80563178716148e-09 1.28945256770884e-07 1.78029803014323 0.585714285714286 8.1 8 1 atrioventricular septal defect 1.77588403755804e-07 8.85982723055157e-06 1.77784018656733 0.584905660377358 8.1 8 1 reduced long term depression 1.82735802579345e-05 0.000554335742580636 1.77306104628086 0.583333333333333 8.1 8 1 abnormal impulse conducting system conduction 0.000467064477640302 0.0084804590374471 1.77306104628086 0.583333333333333 8.1 8 1 increased papilloma incidence 0.0134685781392391 0.12033892281494 1.77306104628086 0.583333333333333 8.1 8 1 abnormal AMPA-mediated synaptic currents 0.0134685781392391 0.12033892281494 1.77306104628086 0.583333333333333 8.1 8 1 loss of dopaminergic neurons 0.0134685781392391 0.12033892281494 1.77306104628086 0.583333333333333 8.1 8 1 abnormal rostral-caudal body axis extension 0.0134685781392391 0.12033892281494 1.77306104628086 0.583333333333333 8.1 8 1 reduced cerebellar foliation 0.0134685781392391 0.12033892281494 1.77306104628086 0.583333333333333 8.1 8 1 increased fibrosarcoma incidence 0.0134685781392391 0.12033892281494 1.77306104628086 0.583333333333333 8.1 8 1 persistent right dorsal aorta 0.0134685781392391 0.12033892281494 1.77306104628086 0.583333333333333 8.1 8 1 abnormal axon morphology 1.14194144278824e-13 1.64802641390527e-11 1.77306104628086 0.583333333333333 8.1 8 1 absent mesoderm 3.17863624105832e-08 1.78461138441408e-06 1.77306104628086 0.583333333333333 8.1 8 1 decreased startle reflex 1.58218857128941e-14 2.71427177316029e-12 1.7665663171736 0.581196581196581 8.1 8 1 abnormal axon extension 5.65185992542373e-07 2.53475495408802e-05 1.76292926887354 0.58 8.1 8 1 increased grooming behavior 1.36629959731691e-05 0.000422195061903827 1.7597297602186 0.578947368421053 8.1 8 1 abnormal stationary movement 0.00209502691560257 0.0289521080697856 1.7597297602186 0.578947368421053 8.1 8 1 stereotypic behavior 0.00209502691560257 0.0289521080697856 1.7597297602186 0.578947368421053 8.1 8 1 abnormal long term depression 0.00209502691560257 0.0289521080697856 1.7597297602186 0.578947368421053 8.1 8 1 maternal imprinting 0.00209502691560257 0.0289521080697856 1.7597297602186 0.578947368421053 8.1 8 1 embryonic lethality between implantation and somite formation, incomplete penetrance 0.00209502691560257 0.0289521080697856 1.7597297602186 0.578947368421053 8.1 8 1 decreased circulating glycerol level 0.00034552845819356 0.00653613718445993 1.75357685895909 0.576923076923077 8.1 8 1 abnormal motor capabilities/coordination/movement 9.46394516883296e-16 1.81088950826708e-13 1.75003427944604 0.575757575757576 8.1 8 1 abnormal posture 4.42327640540266e-10 3.72979662997937e-08 1.74773160276256 0.575 8.1 8 1 reduced long term potentiation 2.74325429257612e-13 3.68856489339628e-11 1.73687612696901 0.571428571428571 8.1 8 1 absent corpus callosum 0.0002552482953474 0.00507944107741326 1.73687612696901 0.571428571428571 8.1 8 1 increased aggression towards males 0.00967263008076445 0.0943555581407905 1.73687612696901 0.571428571428571 8.1 8 1 abnormal pinna reflex 0.00967263008076445 0.0943555581407905 1.73687612696901 0.571428571428571 8.1 8 1 abnormal adrenal gland secretion 0.00967263008076445 0.0943555581407905 1.73687612696901 0.571428571428571 8.1 8 1 abnormal voluntary movement 0.00967263008076445 0.0943555581407905 1.73687612696901 0.571428571428571 8.1 8 1 skeletal muscle necrosis 0.00967263008076445 0.0943555581407905 1.73687612696901 0.571428571428571 8.1 8 1 split sternum 0.00967263008076445 0.0943555581407905 1.73687612696901 0.571428571428571 8.1 8 1 multiple persisting craniopharyngeal ducts 0.00967263008076445 0.0943555581407905 1.73687612696901 0.571428571428571 8.1 8 1 embryonic lethality between somite formation and embryo turning, complete penetrance 7.65700176961169e-09 4.85594852621974e-07 1.73687612696901 0.571428571428571 8.1 8 1 gliosis 4.25914548290295e-08 2.328488876642e-06 1.73687612696901 0.571428571428571 8.1 8 1 abnormal midbrain development 4.36709542613202e-05 0.00116183421096293 1.73687612696901 0.571428571428571 8.1 8 1 abnormal anxiety-related response 0.00153331684952073 0.0228390758274421 1.73687612696901 0.571428571428571 8.1 8 1 abnormal associative learning 0.00153331684952073 0.0228390758274421 1.73687612696901 0.571428571428571 8.1 8 1 left pulmonary isomerism 0.00153331684952073 0.0228390758274421 1.73687612696901 0.571428571428571 8.1 8 1 impaired coordination 1.52270093058631e-37 1.89385928241672e-34 1.73060128546984 0.569364161849711 8.1 8 1 abnormal embryonic neuroepithelium morphology 1.78086979508574e-07 8.85982723055157e-06 1.72938959193897 0.568965517241379 8.1 8 1 abnormal cued conditioning behavior 1.00010500469776e-06 4.07829704784539e-05 1.72836202830739 0.568627450980392 8.1 8 1 failure of chorioallantoic fusion 1.00010500469776e-06 4.07829704784539e-05 1.72836202830739 0.568627450980392 8.1 8 1 impaired righting response 2.56309845084368e-11 2.60232954958109e-09 1.72773467366917 0.568421052631579 8.1 8 1 abnormal response to new environment 0.000188360752038966 0.00393737286299939 1.72240215924426 0.566666666666667 8.1 8 1 atrial septal defect 4.21162455898768e-06 0.000148601646673502 1.71799703863239 0.565217391304348 8.1 8 1 abnormal contextual conditioning behavior 5.55872180575623e-07 2.53475495408802e-05 1.71319145251034 0.563636363636364 8.1 8 1 abnormal depression-related behavior 0.00013889719937377 0.00308488199502012 1.70973743748512 0.5625 8.1 8 1 decreased aggression towards mice 0.0069581480979259 0.0755825039021427 1.70973743748512 0.5625 8.1 8 1 dystonia 0.0069581480979259 0.0755825039021427 1.70973743748512 0.5625 8.1 8 1 decreased midbrain size 0.0069581480979259 0.0755825039021427 1.70973743748512 0.5625 8.1 8 1 decreased exploration in new environment 1.00586498940953e-09 7.81902862861312e-08 1.70069120765715 0.55952380952381 8.1 8 1 abnormal nervous system development 0.000102368146739164 0.00239099309871991 1.69856268299175 0.558823529411765 8.1 8 1 abnormal left-right axis patterning 1.31691874549214e-05 0.000409479422426463 1.69648365889996 0.558139534883721 8.1 8 1 abnormal forebrain development 2.28444709312605e-08 1.35299098670263e-06 1.68862956788653 0.555555555555556 8.1 8 1 abnormal kindling response 0.0470244123085308 0.289179791390532 1.68862956788653 0.555555555555556 8.1 8 1 abnormal ion homeostasis 0.0470244123085308 0.289179791390532 1.68862956788653 0.555555555555556 8.1 8 1 genetic imprinting 0.0470244123085308 0.289179791390532 1.68862956788653 0.555555555555556 8.1 8 1 pancreas cysts 0.0470244123085308 0.289179791390532 1.68862956788653 0.555555555555556 8.1 8 1 short frontal bone 0.0470244123085308 0.289179791390532 1.68862956788653 0.555555555555556 8.1 8 1 abnormal hair cell mechanoelectric transduction 0.0470244123085308 0.289179791390532 1.68862956788653 0.555555555555556 8.1 8 1 increased neuronal precursor cell number 0.0470244123085308 0.289179791390532 1.68862956788653 0.555555555555556 8.1 8 1 abnormal optic chiasm morphology 0.0470244123085308 0.289179791390532 1.68862956788653 0.555555555555556 8.1 8 1 abnormal telomere morphology 0.0470244123085308 0.289179791390532 1.68862956788653 0.555555555555556 8.1 8 1 abnormal coronary sinus connection 0.0470244123085308 0.289179791390532 1.68862956788653 0.555555555555556 8.1 8 1 increased cardiac muscle glycogen level 0.0470244123085308 0.289179791390532 1.68862956788653 0.555555555555556 8.1 8 1 impaired limb coordination 1.28081353242821e-06 5.13874784179867e-05 1.68862956788653 0.555555555555556 8.1 8 1 lethality at weaning, complete penetrance 9.74391129127237e-06 0.000318920780750527 1.68862956788653 0.555555555555556 8.1 8 1 abnormal brain commissure morphology 0.000599949458841734 0.010554767548141 1.68862956788653 0.555555555555556 8.1 8 1 abnormal skin appearance 0.000599949458841734 0.010554767548141 1.68862956788653 0.555555555555556 8.1 8 1 neuron degeneration 7.20669158272456e-06 0.000242251963676045 1.68144391015085 0.553191489361702 8.1 8 1 increased susceptibility to pharmacologically induced seizures 1.72961197681244e-10 1.50961747098981e-08 1.67807563308724 0.552083333333333 8.1 8 1 abnormal neuron proliferation 0.00361971758261491 0.0458221246145272 1.67174327220767 0.55 8.1 8 1 abnormal behavior 1.02290170456698e-26 5.08893598022074e-24 1.66190305674013 0.546762589928058 8.1 8 1 abnormal germ layer development 0.00261720766130045 0.0348144602004539 1.65792721210678 0.545454545454545 8.1 8 1 abnormal ear position 0.0327581706481292 0.222639206249239 1.65792721210678 0.545454545454545 8.1 8 1 premature suture closure 0.0327581706481292 0.222639206249239 1.65792721210678 0.545454545454545 8.1 8 1 delayed hepatic development 0.0327581706481292 0.222639206249239 1.65792721210678 0.545454545454545 8.1 8 1 failure of somite differentiation 0.0327581706481292 0.222639206249239 1.65792721210678 0.545454545454545 8.1 8 1 abnormal nerve fiber response 0.0327581706481292 0.222639206249239 1.65792721210678 0.545454545454545 8.1 8 1 abnormal coronal suture morphology 0.0327581706481292 0.222639206249239 1.65792721210678 0.545454545454545 8.1 8 1 abnormal pulmonary alveolar sac morphology 0.0327581706481292 0.222639206249239 1.65792721210678 0.545454545454545 8.1 8 1 abnormal phrenic nerve innervation pattern to diaphragm 0.0327581706481292 0.222639206249239 1.65792721210678 0.545454545454545 8.1 8 1 ventricular septal defect 1.25728266304648e-13 1.7374947912934e-11 1.65386366501828 0.544117647058823 8.1 8 1 abnormal locomotor behavior 1.17240235812058e-09 8.70552497261177e-08 1.65192022945422 0.543478260869565 8.1 8 1 abnormal cell death 1.63299669249448e-05 0.000501491268219756 1.65192022945422 0.543478260869565 8.1 8 1 increased carcinoma incidence 0.000172071062806602 0.00365834845069593 1.65003232062056 0.542857142857143 8.1 8 1 impaired behavioral response to xenobiotic 0.000172071062806602 0.00365834845069593 1.65003232062056 0.542857142857143 8.1 8 1 hyperactivity 3.90962561729172e-34 3.89007748920526e-31 1.64675519585269 0.54177897574124 8.1 8 1 vertebral transformation 1.20239739822866e-05 0.000378602978239722 1.64641382868937 0.541666666666667 8.1 8 1 abnormal nursing 0.00189516781064392 0.0270932754538894 1.64641382868937 0.541666666666667 8.1 8 1 increased stereotypic behavior 0.00189516781064392 0.0270932754538894 1.64641382868937 0.541666666666667 8.1 8 1 abnormal breathing pattern 0.000126025409863347 0.00282421808139707 1.64299093091663 0.540540540540541 8.1 8 1 increased startle reflex 3.51002538308012e-09 2.32831683744315e-07 1.63929881646513 0.539325842696629 8.1 8 1 abnormal cell cycle 1.98747517110708e-11 2.10376361196973e-09 1.63870486761858 0.539130434782609 8.1 8 1 kinked neural tube 6.51983642899317e-06 0.000220654328124089 1.63667173502849 0.538461538461538 8.1 8 1 increased foot pad pigmentation 0.0230155385269842 0.173225876205365 1.63667173502849 0.538461538461538 8.1 8 1 abnormal coping response 0.0230155385269842 0.173225876205365 1.63667173502849 0.538461538461538 8.1 8 1 abnormal telomere length 0.0230155385269842 0.173225876205365 1.63667173502849 0.538461538461538 8.1 8 1 muscle fatigue 0.0230155385269842 0.173225876205365 1.63667173502849 0.538461538461538 8.1 8 1 abnormal retinal inner plexiform layer morphology 0.0230155385269842 0.173225876205365 1.63667173502849 0.538461538461538 8.1 8 1 orthokeratosis 0.0230155385269842 0.173225876205365 1.63667173502849 0.538461538461538 8.1 8 1 decreased cardiac stroke volume 0.0230155385269842 0.173225876205365 1.63667173502849 0.538461538461538 8.1 8 1 absent hypoglossal nerve 0.0230155385269842 0.173225876205365 1.63667173502849 0.538461538461538 8.1 8 1 neurodegeneration 4.80148700652265e-06 0.000165884707343404 1.63234191562365 0.537037037037037 8.1 8 1 abnormal neuronal precursor proliferation 4.80148700652265e-06 0.000165884707343404 1.63234191562365 0.537037037037037 8.1 8 1 abnormal cell differentiation 6.7673260050177e-05 0.00167499735696334 1.63096904605626 0.536585365853659 8.1 8 1 abnormal neuron morphology 7.82676992920174e-10 6.38330826193093e-08 1.62722485632702 0.535353535353535 8.1 8 1 abnormal optic cup morphology 0.000725152175856774 0.0123549043660529 1.62108438517107 0.533333333333333 8.1 8 1 audiogenic seizures 0.0162760122554757 0.131236889742288 1.62108438517107 0.533333333333333 8.1 8 1 absent egg cylinders 0.0162760122554757 0.131236889742288 1.62108438517107 0.533333333333333 8.1 8 1 decreased aggression towards males 0.0162760122554757 0.131236889742288 1.62108438517107 0.533333333333333 8.1 8 1 abnormal trophectoderm morphology 0.0162760122554757 0.131236889742288 1.62108438517107 0.533333333333333 8.1 8 1 abnormal olfactory nerve morphology 0.0162760122554757 0.131236889742288 1.62108438517107 0.533333333333333 8.1 8 1 immune system phenotype 0.0162760122554757 0.131236889742288 1.62108438517107 0.533333333333333 8.1 8 1 abnormal energy homeostasis 0.0162760122554757 0.131236889742288 1.62108438517107 0.533333333333333 8.1 8 1 abnormal cell nucleus morphology 2.66973252683767e-05 0.000767741001214879 1.61677299052966 0.531914893617021 8.1 8 1 abnormal long term potentiation 0.000527616752079657 0.00947614924764005 1.6147520242915 0.53125 8.1 8 1 abnormal neural tube closure 3.09029012286704e-08 1.7671486622142e-06 1.6113188165857 0.530120481927711 8.1 8 1 abnormal extraembryonic tissue morphology 9.35289676593425e-10 7.38581927151157e-08 1.60916464704481 0.529411764705882 8.1 8 1 pericardial edema 5.65543316389489e-07 2.53475495408802e-05 1.60916464704481 0.529411764705882 8.1 8 1 abnormal glutamate-mediated receptor currents 0.0115692652550477 0.107987044359967 1.60916464704481 0.529411764705882 8.1 8 1 enhanced behavioral response to cocaine 0.0115692652550477 0.107987044359967 1.60916464704481 0.529411764705882 8.1 8 1 abnormal electroretinogram waveform feature 0.0115692652550477 0.107987044359967 1.60916464704481 0.529411764705882 8.1 8 1 delayed heart development 0.0115692652550477 0.107987044359967 1.60916464704481 0.529411764705882 8.1 8 1 abnormal neuromuscular synapse morphology 3.07218992766043e-07 1.46962931635679e-05 1.60419808949221 0.527777777777778 8.1 8 1 abnormal locomotor activation 9.19428252424578e-09 5.6471056244596e-07 1.60327027104831 0.527472527472527 8.1 8 1 abnormal cell morphology 1.52908110189968e-10 1.38312336035471e-08 1.59975432747145 0.526315789473684 8.1 8 1 right-sided stomach 0.00825795455807434 0.0852351118805391 1.59975432747145 0.526315789473684 8.1 8 1 abnormal developmental patterning 6.69299323474334e-08 3.54230227051576e-06 1.5939015677368 0.524390243902439 8.1 8 1 abnormal allantois morphology 5.82723320979557e-05 0.00146416592013803 1.58584342027605 0.521739130434783 8.1 8 1 increased susceptibility to age related obesity 0.00424876674060973 0.0498528644682391 1.58584342027605 0.521739130434783 8.1 8 1 abnormal spatial learning 5.1147713679958e-14 8.20838308250938e-12 1.58503266188123 0.521472392638037 8.1 8 1 short stride length 3.1226839793865e-05 0.000882690499854992 1.5805572755418 0.52 8.1 8 1 absent corpus luteum 2.28758780710936e-05 0.000669455843551123 1.57821917306318 0.519230769230769 8.1 8 1 abnormal apoptosis 1.67656453266384e-05 0.000511712180981756 1.57605426336076 0.518518518518518 8.1 8 1 increased brain weight 0.0022080035369806 0.0303594206559172 1.57605426336076 0.518518518518518 8.1 8 1 abnormal locomotor coordination 0.000838498775592502 0.0139516100621161 1.56582014476751 0.515151515151515 8.1 8 1 abnormal embryonic epiblast morphology 0.000608925257744224 0.010666912525625 1.56318851427211 0.514285714285714 8.1 8 1 double outlet right ventricle 2.72021006187792e-09 1.85384178874557e-07 1.56237688991371 0.514018691588785 8.1 8 1 malocclusion 0.000442724918370432 0.00812751464536126 1.5608413843708 0.513513513513513 8.1 8 1 abnormal neural tube morphology 3.5791302284157e-13 4.565685355479e-11 1.55729171260647 0.512345679012346 8.1 8 1 abnormal vasculogenesis 0.0001711717270827 0.00365834845069593 1.5551100206583 0.511627906976744 8.1 8 1 abnormal myocardial trabeculae morphology 0.000124911537686376 0.00282344221786514 1.55353920245561 0.511111111111111 8.1 8 1 embryonic growth arrest 7.8350968132116e-18 1.85617174503465e-15 1.55294928819609 0.510917030567686 8.1 8 1 increased anxiety-related response 2.10426760626354e-11 2.18098569607524e-09 1.55256732932301 0.510791366906475 8.1 8 1 embryonic lethality between implantation and somite formation, complete penetrance 6.94767335388932e-19 1.81919341766313e-16 1.55078225622233 0.510204081632653 8.1 8 1 abnormal embryonic tissue morphology 6.25218427093907e-12 7.2336318018423e-10 1.55078225622233 0.510204081632653 8.1 8 1 abnormal response to novel object 4.87441024722813e-05 0.00125000984432783 1.54956595641353 0.509803921568627 8.1 8 1 abnormal mesoderm development 3.56633588627059e-05 0.000974863793087701 1.54844145281671 0.509433962264151 8.1 8 1 abnormal brain morphology 7.48406336752502e-13 9.30830381335924e-11 1.54808524360281 0.509316770186335 8.1 8 1 incomplete embryo turning 1.9120571007532e-05 0.000573041209412482 1.5464291832224 0.508771929824561 8.1 8 1 decreased rib number 1.37341217123333e-07 7.04404696070705e-06 1.53684264043606 0.50561797752809 8.1 8 1 limb grasping 5.53503086881247e-14 8.60524330385688e-12 1.53646734308797 0.505494505494505 8.1 8 1 reduced fertility 6.70340941644741e-11 6.53911016604429e-09 1.53070018383959 0.503597122302158 8.1 8 1 enhanced coordination 0.00341832550339525 0.0436055625112599 1.51976661109788 0.5 8.1 8 1 hypoxia 0.00341832550339525 0.0436055625112599 1.51976661109788 0.5 8.1 8 1 abnormal endplate potential 0.036358446973204 0.235832169089556 1.51976661109788 0.5 8.1 8 1 increased hemangioma incidence 0.036358446973204 0.235832169089556 1.51976661109788 0.5 8.1 8 1 abnormal ventral body wall morphology 0.036358446973204 0.235832169089556 1.51976661109788 0.5 8.1 8 1 abnormal renal reabsorbtion 0.036358446973204 0.235832169089556 1.51976661109788 0.5 8.1 8 1 increased stomach tumor incidence 0.036358446973204 0.235832169089556 1.51976661109788 0.5 8.1 8 1 increased tumor incidence 1.16008323363606e-09 8.70552497261177e-08 1.51976661109788 0.5 8.1 8 1 small liver 1.32108249254984e-06 5.25790832034836e-05 1.51976661109788 0.5 8.1 8 1 axon degeneration 5.4561072398773e-05 0.00138490477134641 1.51976661109788 0.5 8.1 8 1 distended pericardium 7.46123268734687e-05 0.00180192391357042 1.51976661109788 0.5 8.1 8 1 muscular atrophy 0.000262676585603685 0.00514494493456036 1.51976661109788 0.5 8.1 8 1 embryonic lethality, incomplete penetrance 0.000262676585603685 0.00514494493456036 1.51976661109788 0.5 8.1 8 1 abnormal optic nerve morphology 0.00036052206467397 0.00676829159152075 1.51976661109788 0.5 8.1 8 1 abnormal pharyngeal arch morphology 0.000937755074459496 0.0150162977809097 1.51976661109788 0.5 8.1 8 1 scoliosis 0.00178464533009174 0.0258851618577446 1.51976661109788 0.5 8.1 8 1 failure of primitive streak formation 0.00178464533009174 0.0258851618577446 1.51976661109788 0.5 8.1 8 1 abnormal heart atrium morphology 0.00178464533009174 0.0258851618577446 1.51976661109788 0.5 8.1 8 1 ventricular hypoplasia 0.00474502057241776 0.0546446234902277 1.51976661109788 0.5 8.1 8 1 increased thymocyte apoptosis 0.00474502057241776 0.0546446234902277 1.51976661109788 0.5 8.1 8 1 abnormal vascular branching morphogenesis 0.00921230911673655 0.0939164710159105 1.51976661109788 0.5 8.1 8 1 abnormal limb posture 0.00921230911673655 0.0939164710159105 1.51976661109788 0.5 8.1 8 1 anencephaly 0.0128961915335338 0.117291687165138 1.51976661109788 0.5 8.1 8 1 abnormal postnatal subventricular zone morphology 0.0128961915335338 0.117291687165138 1.51976661109788 0.5 8.1 8 1 increased skin tumor incidence 0.0128961915335338 0.117291687165138 1.51976661109788 0.5 8.1 8 1 absent ductus venosus valve 0.0128961915335338 0.117291687165138 1.51976661109788 0.5 8.1 8 1 absent allantois 0.0181242220796378 0.143808620169375 1.51976661109788 0.5 8.1 8 1 abnormal body wall morphology 0.0181242220796378 0.143808620169375 1.51976661109788 0.5 8.1 8 1 absent inner cell mass 0.0181242220796378 0.143808620169375 1.51976661109788 0.5 8.1 8 1 increased gastrointestinal tumor incidence 0.0181242220796378 0.143808620169375 1.51976661109788 0.5 8.1 8 1 primary atelectasis 0.0181242220796378 0.143808620169375 1.51976661109788 0.5 8.1 8 1 abnormal hypoglossal nerve topology 0.0181242220796378 0.143808620169375 1.51976661109788 0.5 8.1 8 1 increased adipocyte glucose uptake 0.0181242220796378 0.143808620169375 1.51976661109788 0.5 8.1 8 1 vasculature congestion 0.0255938764130256 0.188916224265285 1.51976661109788 0.5 8.1 8 1 abnormal olfaction 0.0255938764130256 0.188916224265285 1.51976661109788 0.5 8.1 8 1 increased pancreatic beta cell number 0.0255938764130256 0.188916224265285 1.51976661109788 0.5 8.1 8 1 increased cochlear outer hair cell number 0.0255938764130256 0.188916224265285 1.51976661109788 0.5 8.1 8 1 blepharitis 0.0255938764130256 0.188916224265285 1.51976661109788 0.5 8.1 8 1 abnormal mineral level 0.0520477631570193 0.297287740190782 1.51976661109788 0.5 8.1 8 1 abnormal superior cervical ganglion morphology 0.0520477631570193 0.297287740190782 1.51976661109788 0.5 8.1 8 1 abnormal mating frequency 0.0520477631570193 0.297287740190782 1.51976661109788 0.5 8.1 8 1 impaired embryo implantation 0.0520477631570193 0.297287740190782 1.51976661109788 0.5 8.1 8 1 abnormal thymus involution 0.0520477631570193 0.297287740190782 1.51976661109788 0.5 8.1 8 1 abnormal embryonic growth/weight/body size 0.0520477631570193 0.297287740190782 1.51976661109788 0.5 8.1 8 1 increased growth rate 0.0520477631570193 0.297287740190782 1.51976661109788 0.5 8.1 8 1 abnormal nucleotide metabolism 0.0520477631570193 0.297287740190782 1.51976661109788 0.5 8.1 8 1 stria vascularis degeneration 0.0520477631570193 0.297287740190782 1.51976661109788 0.5 8.1 8 1 abnormal amacrine cell morphology 0.0520477631570193 0.297287740190782 1.51976661109788 0.5 8.1 8 1 decreased mammary gland epithelial cell proliferation 0.0520477631570193 0.297287740190782 1.51976661109788 0.5 8.1 8 1 abnormal pulmonary valve cusp morphology 0.0520477631570193 0.297287740190782 1.51976661109788 0.5 8.1 8 1 embryonic lethality between implantation and placentation, incomplete penetrance 0.0520477631570193 0.297287740190782 1.51976661109788 0.5 8.1 8 1 jaundice 0.0752720372309302 0.35824825814357 1.51976661109788 0.5 8.1 8 1 rhinitis 0.0752720372309302 0.35824825814357 1.51976661109788 0.5 8.1 8 1 alcohol preference 0.0752720372309302 0.35824825814357 1.51976661109788 0.5 8.1 8 1 ketoaciduria 0.0752720372309302 0.35824825814357 1.51976661109788 0.5 8.1 8 1 abnormal scala media morphology 0.0752720372309302 0.35824825814357 1.51976661109788 0.5 8.1 8 1 increased defecation amount 0.0752720372309302 0.35824825814357 1.51976661109788 0.5 8.1 8 1 absent pharyngeal arches 0.0752720372309302 0.35824825814357 1.51976661109788 0.5 8.1 8 1 abnormal ear physiology 0.0752720372309302 0.35824825814357 1.51976661109788 0.5 8.1 8 1 abnormal gas homeostasis 0.0752720372309302 0.35824825814357 1.51976661109788 0.5 8.1 8 1 abnormal embryonic erythrocyte morphology 0.0752720372309302 0.35824825814357 1.51976661109788 0.5 8.1 8 1 abnormal utricular macula morphology 0.0752720372309302 0.35824825814357 1.51976661109788 0.5 8.1 8 1 decreased cochlear inner hair cell number 0.0752720372309302 0.35824825814357 1.51976661109788 0.5 8.1 8 1 osteosclerosis 0.0752720372309302 0.35824825814357 1.51976661109788 0.5 8.1 8 1 abnormal sperm principal piece morphology 0.0752720372309302 0.35824825814357 1.51976661109788 0.5 8.1 8 1 increased serotonin level 0.0752720372309302 0.35824825814357 1.51976661109788 0.5 8.1 8 1 increased circulating fructosamine level 0.0752720372309302 0.35824825814357 1.51976661109788 0.5 8.1 8 1 abnormal left subclavian artery morphology 0.0752720372309302 0.35824825814357 1.51976661109788 0.5 8.1 8 1 abnormal inferior vena cava valve morphology 0.0752720372309302 0.35824825814357 1.51976661109788 0.5 8.1 8 1 sinus bradycardia 0.0752720372309302 0.35824825814357 1.51976661109788 0.5 8.1 8 1 abnormal eating behavior 2.14048018791364e-05 0.000637658020052117 1.51976661109788 0.5 8.1 8 1 abnormal microglial cell physiology 0.00246767843830092 0.0331802708933705 1.51976661109788 0.5 8.1 8 1 embryonic lethality, complete penetrance 2.86534020224093e-22 1.01821910758205e-19 1.5150024524424 0.498432601880878 8.1 8 1 decreased anxiety-related response 2.36911396498087e-09 1.64662765629351e-07 1.50741078499139 0.495934959349593 8.1 8 1 abnormal craniofacial morphology 5.00902889261571e-08 2.70868681964817e-06 1.50501159545615 0.495145631067961 8.1 8 1 abnormal embryo development 5.70371549907101e-10 4.72933076797971e-08 1.49741710211115 0.492647058823529 8.1 8 1 decreased embryo size 4.21607811217728e-31 2.62187357601025e-28 1.49433118664436 0.49163179916318 8.1 8 1 pallor 2.65470553594867e-12 3.14456191460587e-10 1.49371346919335 0.491428571428571 8.1 8 1 decreased brain weight 6.00042768126662e-05 0.00150010692031666 1.49310403897336 0.491228070175439 8.1 8 1 abnormal head morphology 8.19991033813479e-05 0.00196127663135676 1.4921344908961 0.490909090909091 8.1 8 1 abnormal embryo turning 8.19991033813479e-05 0.00196127663135676 1.4921344908961 0.490909090909091 8.1 8 1 abnormal gastrulation 0.000153394092337494 0.00331798091034362 1.48996726578224 0.490196078431373 8.1 8 1 increased T cell derived lymphoma incidence 0.000210001152141515 0.00429560402348673 1.48875096597343 0.489795918367347 8.1 8 1 decreased insulin secretion 6.36284277918586e-07 2.82635203807586e-05 1.48599401974015 0.488888888888889 8.1 8 1 decreased grip strength 1.00724924201933e-14 1.78966606394506e-12 1.4850687432646 0.488584474885845 8.1 8 1 lethality at weaning, incomplete penetrance 0.000743403906298904 0.0126226431188978 1.48269913277842 0.48780487804878 8.1 8 1 abnormal social investigation 2.95453881464502e-06 0.000109692765692977 1.48177244582043 0.4875 8.1 8 1 abnormal nervous system physiology 2.40448114007528e-08 1.39681484530305e-06 1.48012052559098 0.48695652173913 8.1 8 1 abnormal embryo size 3.26085788363692e-08 1.80252977456596e-06 1.47941882496254 0.486725663716814 8.1 8 1 abnormal pancreatic beta cell physiology 0.00140673101180703 0.021271996303161 1.47869183782496 0.486486486486487 8.1 8 1 abnormal respiratory electron transport chain 0.00140673101180703 0.021271996303161 1.47869183782496 0.486486486486487 8.1 8 1 infertility 8.13807726119832e-08 4.26178256573281e-06 1.47715633228205 0.485981308411215 8.1 8 1 increased circulating serum albumin level 0.00193856535542514 0.027634276914728 1.47634470792366 0.485714285714286 8.1 8 1 decreased mean corpuscular hemoglobin 1.88036058213517e-05 0.000566957205825606 1.47506759312441 0.485294117647059 8.1 8 1 pericardial effusion 4.76447899672553e-05 0.00123707510778132 1.47074188170763 0.483870967741935 8.1 8 1 preaxial polydactyly 0.00369725412319019 0.046452466870228 1.47074188170763 0.483870967741935 8.1 8 1 anophthalmia 1.27341950594206e-06 5.13874784179867e-05 1.46853852308334 0.48314606741573 8.1 8 1 lordosis 0.0051187750199572 0.0584080406520346 1.46736086588761 0.482758620689655 8.1 8 1 increased neuron apoptosis 4.34151285405294e-06 0.00015210582006277 1.463478958835 0.481481481481481 8.1 8 1 increased cell proliferation 0.000165565146619961 0.00356574287633898 1.463478958835 0.481481481481481 8.1 8 1 abnormal atrioventricular cushion morphology 0.00710082210532372 0.0759101337736693 1.463478958835 0.481481481481481 8.1 8 1 thin epidermis 0.00710082210532372 0.0759101337736693 1.463478958835 0.481481481481481 8.1 8 1 abnormal fetal cardiomyocyte proliferation 0.00710082210532372 0.0759101337736693 1.463478958835 0.481481481481481 8.1 8 1 abnormal somite development 5.90237295694207e-06 0.000201125379868403 1.46205395498024 0.481012658227848 8.1 8 1 overriding aortic valve 0.000423775476900174 0.00783748326237311 1.45644300230214 0.479166666666667 8.1 8 1 small heart 0.000423775476900174 0.00783748326237311 1.45644300230214 0.479166666666667 8.1 8 1 microcephaly 2.7511982682196e-05 0.000782126364822429 1.45368980191971 0.478260869565217 8.1 8 1 abnormal myelin sheath morphology 0.000580444528920234 0.0103502205425741 1.45368980191971 0.478260869565217 8.1 8 1 spina bifida 0.00109147830777613 0.0172384272418611 1.44739677247417 0.476190476190476 8.1 8 1 small ears 0.0192429489376386 0.149350500725042 1.44739677247417 0.476190476190476 8.1 8 1 complete atrioventricular septal defect 0.0192429489376386 0.149350500725042 1.44739677247417 0.476190476190476 8.1 8 1 embryonic lethality at implantation, complete penetrance 0.0192429489376386 0.149350500725042 1.44739677247417 0.476190476190476 8.1 8 1 absent segment of posterior cerebral artery 0.0192429489376386 0.149350500725042 1.44739677247417 0.476190476190476 8.1 8 1 increased circulating alkaline phosphatase level 2.71616802836749e-10 2.32981654157384e-08 1.4447164080807 0.475308641975309 8.1 8 1 abnormal facial morphology 0.000176229067612563 0.00373080685690426 1.43977889472431 0.473684210526316 8.1 8 1 decreased hair follicle number 0.00205978419098366 0.0288659897187146 1.43977889472431 0.473684210526316 8.1 8 1 decreased neuron apoptosis 0.00205978419098366 0.0288659897187146 1.43977889472431 0.473684210526316 8.1 8 1 hyporesponsive to tactile stimuli 0.00205978419098366 0.0288659897187146 1.43977889472431 0.473684210526316 8.1 8 1 unresponsive to tactile stimuli 0.0270038628490449 0.190559174005671 1.43977889472431 0.473684210526316 8.1 8 1 decreased chemically-elicited antinociception 0.0270038628490449 0.190559174005671 1.43977889472431 0.473684210526316 8.1 8 1 abnormal ear morphology 0.0270038628490449 0.190559174005671 1.43977889472431 0.473684210526316 8.1 8 1 decreased germ cell number 0.0270038628490449 0.190559174005671 1.43977889472431 0.473684210526316 8.1 8 1 abnormal digestive system development 0.0270038628490449 0.190559174005671 1.43977889472431 0.473684210526316 8.1 8 1 abnormal photoreceptor inner segment morphology 0.0270038628490449 0.190559174005671 1.43977889472431 0.473684210526316 8.1 8 1 abnormal cochlear inner hair cell morphology 0.0270038628490449 0.190559174005671 1.43977889472431 0.473684210526316 8.1 8 1 Leydig cell hypoplasia 0.0270038628490449 0.190559174005671 1.43977889472431 0.473684210526316 8.1 8 1 abnormal behavioral response to xenobiotic 0.0270038628490449 0.190559174005671 1.43977889472431 0.473684210526316 8.1 8 1 embryonic lethality during organogenesis, complete penetrance 1.88624268727516e-31 1.34057962417056e-28 1.43835054264621 0.473214285714286 8.1 8 1 abnormal learning/memory/conditioning 0.000240486426764925 0.00480489949058434 1.43687025049254 0.472727272727273 8.1 8 1 abnormal rostral-caudal axis patterning 0.000240486426764925 0.00480489949058434 1.43687025049254 0.472727272727273 8.1 8 1 abnormal trophoblast giant cell morphology 0.00283402718576283 0.0374980990669417 1.43533513270355 0.472222222222222 8.1 8 1 abnormal muscle physiology 3.63373450173429e-06 0.000131954957271008 1.43438646440699 0.471910112359551 8.1 8 1 increased or absent threshold for auditory brainstem response 1.39681380572761e-16 3.02136899282385e-14 1.43036857515095 0.470588235294118 8.1 8 1 enlarged liver sinusoidal spaces 0.00390393268472931 0.0477200616868018 1.43036857515095 0.470588235294118 8.1 8 1 hydroureter 0.0380601974423393 0.243980728379134 1.43036857515095 0.470588235294118 8.1 8 1 increased aggression towards mice 0.0380601974423393 0.243980728379134 1.43036857515095 0.470588235294118 8.1 8 1 pancytopenia 0.0380601974423393 0.243980728379134 1.43036857515095 0.470588235294118 8.1 8 1 coloboma 0.0380601974423393 0.243980728379134 1.43036857515095 0.470588235294118 8.1 8 1 common atrium 0.0380601974423393 0.243980728379134 1.43036857515095 0.470588235294118 8.1 8 1 abnormal ductus venosus valve morphology 0.0380601974423393 0.243980728379134 1.43036857515095 0.470588235294118 8.1 8 1 abnormal vascular development 7.35189662864514e-05 0.00179292577095635 1.42765954375861 0.46969696969697 8.1 8 1 hypoactivity 5.34364306053128e-21 1.56380142506724e-18 1.4270487541874 0.469496021220159 8.1 8 1 increased exploration in new environment 1.23057872505198e-05 0.000385039569631044 1.42595385732641 0.469135802469136 8.1 8 1 lethality throughout fetal growth and development, complete penetrance 3.09731907669961e-11 3.08183248131611e-09 1.42378135144959 0.468421052631579 8.1 8 1 abnormal innervation 0.000838058939539113 0.0139516100621161 1.4227602316661 0.468085106382979 8.1 8 1 preweaning lethality, complete penetrance 2.30415414618343e-39 5.73158343863127e-36 1.42118715524288 0.467567567567568 8.1 8 1 preweaning lethality, incomplete penetrance 3.26959311104246e-22 1.08441504849575e-19 1.41943971990071 0.466992665036675 8.1 8 1 abnormal erythropoiesis 8.84955987467798e-07 3.73106443868838e-05 1.41844883702469 0.466666666666667 8.1 8 1 abnormal ectoderm development 0.00114665980022121 0.0177714408289735 1.41844883702469 0.466666666666667 8.1 8 1 small placenta 0.00114665980022121 0.0177714408289735 1.41844883702469 0.466666666666667 8.1 8 1 abnormal brain vasculature morphology 0.00743848452890644 0.0784035180748083 1.41844883702469 0.466666666666667 8.1 8 1 abnormal seizure response to electrical stimulation 0.0539305773512161 0.299882437744632 1.41844883702469 0.466666666666667 8.1 8 1 dilated ureter 0.0539305773512161 0.299882437744632 1.41844883702469 0.466666666666667 8.1 8 1 absent chorion 0.0539305773512161 0.299882437744632 1.41844883702469 0.466666666666667 8.1 8 1 abnormal secondary palate development 0.0539305773512161 0.299882437744632 1.41844883702469 0.466666666666667 8.1 8 1 ostium primum atrial septal defect 0.0539305773512161 0.299882437744632 1.41844883702469 0.466666666666667 8.1 8 1 heterochrony 0.0539305773512161 0.299882437744632 1.41844883702469 0.466666666666667 8.1 8 1 seminiferous tubule degeneration 4.17590602734446e-05 0.00111694260677627 1.41567300759803 0.465753424657534 8.1 8 1 abnormal double-strand DNA break repair 0.00156992416780897 0.0233145454771631 1.41373638241663 0.465116279069767 8.1 8 1 decreased birth body size 3.75382361234024e-07 1.74535256741988e-05 1.41311632259978 0.464912280701754 8.1 8 1 decreased cell proliferation 1.07738611341671e-10 1.0113199838204e-08 1.4129722005883 0.464864864864865 8.1 8 1 decreased circulating serum albumin level 2.19106342772743e-06 8.25798526738178e-05 1.41230836586874 0.464646464646465 8.1 8 1 abnormal eye development 0.000343889473200787 0.00652996232509129 1.41121185316232 0.464285714285714 8.1 8 1 lymphoid hyperplasia 0.0102923191603284 0.098659514109121 1.41121185316232 0.464285714285714 8.1 8 1 abnormal somite shape 0.0102923191603284 0.098659514109121 1.41121185316232 0.464285714285714 8.1 8 1 abnormal retinal inner nuclear layer morphology 0.0102923191603284 0.098659514109121 1.41121185316232 0.464285714285714 8.1 8 1 increased bone resorption 0.0102923191603284 0.098659514109121 1.41121185316232 0.464285714285714 8.1 8 1 abnormal brainstem morphology 0.0102923191603284 0.098659514109121 1.41121185316232 0.464285714285714 8.1 8 1 subcutaneous edema 0.0102923191603284 0.098659514109121 1.41121185316232 0.464285714285714 8.1 8 1 abnormal heart development 3.70685727533224e-09 2.42652828220762e-07 1.4043412988626 0.462025316455696 8.1 8 1 increased embryonic tissue cell apoptosis 3.2108749729706e-05 0.000902491694380156 1.40286148716727 0.461538461538462 8.1 8 1 abnormal ureter morphology 0.0142676726547509 0.124306572171089 1.40286148716727 0.461538461538462 8.1 8 1 abnormal nerve conduction 0.0142676726547509 0.124306572171089 1.40286148716727 0.461538461538462 8.1 8 1 abnormal grip strength 0.0769325271256209 0.360055806632139 1.40286148716727 0.461538461538462 8.1 8 1 abnormal digestion 0.0769325271256209 0.360055806632139 1.40286148716727 0.461538461538462 8.1 8 1 increased pituitary adenoma incidence 0.0769325271256209 0.360055806632139 1.40286148716727 0.461538461538462 8.1 8 1 abnormal pulmonary alveolus epithelial cell morphology 0.0769325271256209 0.360055806632139 1.40286148716727 0.461538461538462 8.1 8 1 dystrophic cardiac calcinosis 0.0769325271256209 0.360055806632139 1.40286148716727 0.461538461538462 8.1 8 1 empty decidua capsularis 0.0769325271256209 0.360055806632139 1.40286148716727 0.461538461538462 8.1 8 1 increased prostaglandin level 0.0769325271256209 0.360055806632139 1.40286148716727 0.461538461538462 8.1 8 1 abnormal aorta tunica media morphology 0.0769325271256209 0.360055806632139 1.40286148716727 0.461538461538462 8.1 8 1 abnormal gait 3.70485260720036e-16 7.37265668832872e-14 1.39680814741682 0.459546925566343 8.1 8 1 abnormal vocalization 0.00404722893362526 0.0480548065508011 1.39654229127913 0.459459459459459 8.1 8 1 abnormal maternal nurturing 0.000262243776592912 0.00514494493456036 1.39519557740133 0.459016393442623 8.1 8 1 abnormal body weight 0.0198205637461644 0.152171766415383 1.39311939350639 0.458333333333333 8.1 8 1 abnormal startle reflex 0.0198205637461644 0.152171766415383 1.39311939350639 0.458333333333333 8.1 8 1 abnormal sensory capabilities/reflexes/nociception 0.0198205637461644 0.152171766415383 1.39311939350639 0.458333333333333 8.1 8 1 abnormal primitive streak formation 0.0198205637461644 0.152171766415383 1.39311939350639 0.458333333333333 8.1 8 1 abnormal liver development 0.00555897885677492 0.0624287128949328 1.38950090157521 0.457142857142857 8.1 8 1 abnormal sleep pattern 0.00162228062811403 0.0240203753716288 1.38761299274154 0.456521739130435 8.1 8 1 hunched posture 4.5010236369808e-05 0.00119109535074359 1.38510374682338 0.455696202531646 8.1 8 1 abnormal astrocyte morphology 0.0022151697885624 0.0303594206559172 1.38160601008898 0.454545454545455 8.1 8 1 omphalocele 0.0022151697885624 0.0303594206559172 1.38160601008898 0.454545454545455 8.1 8 1 decreased brown adipose tissue amount 0.00764294504392222 0.0798816209947753 1.38160601008898 0.454545454545455 8.1 8 1 increased cardiomyocyte apoptosis 0.00764294504392222 0.0798816209947753 1.38160601008898 0.454545454545455 8.1 8 1 increased body size 0.0276018154550569 0.192029573637943 1.38160601008898 0.454545454545455 8.1 8 1 increased skin papilloma incidence 0.0276018154550569 0.192029573637943 1.38160601008898 0.454545454545455 8.1 8 1 abnormal retinal outer plexiform layer morphology 0.0276018154550569 0.192029573637943 1.38160601008898 0.454545454545455 8.1 8 1 embryonic lethality before implantation, incomplete penetrance 0.0276018154550569 0.192029573637943 1.38160601008898 0.454545454545455 8.1 8 1 abnormal thrombopoiesis 0.110700259383264 0.452533928045801 1.38160601008898 0.454545454545455 8.1 8 1 abnormal glossopharyngeal ganglion morphology 0.110700259383264 0.452533928045801 1.38160601008898 0.454545454545455 8.1 8 1 impaired myelopoiesis 0.110700259383264 0.452533928045801 1.38160601008898 0.454545454545455 8.1 8 1 decreased post-tetanic potentiation 0.110700259383264 0.452533928045801 1.38160601008898 0.454545454545455 8.1 8 1 allodynia 0.110700259383264 0.452533928045801 1.38160601008898 0.454545454545455 8.1 8 1 fused joints 0.110700259383264 0.452533928045801 1.38160601008898 0.454545454545455 8.1 8 1 loss of cortex neurons 0.110700259383264 0.452533928045801 1.38160601008898 0.454545454545455 8.1 8 1 abnormal ureter development 0.110700259383264 0.452533928045801 1.38160601008898 0.454545454545455 8.1 8 1 abnormal crista ampullaris neuroepithelium morphology 0.110700259383264 0.452533928045801 1.38160601008898 0.454545454545455 8.1 8 1 cyclopia 0.110700259383264 0.452533928045801 1.38160601008898 0.454545454545455 8.1 8 1 increased circulating triiodothyronine level 0.110700259383264 0.452533928045801 1.38160601008898 0.454545454545455 8.1 8 1 enhanced behavioral response to addictive substance 0.110700259383264 0.452533928045801 1.38160601008898 0.454545454545455 8.1 8 1 palatal shelf hypoplasia 0.110700259383264 0.452533928045801 1.38160601008898 0.454545454545455 8.1 8 1 decreased palatine bone horizontal plate size 0.110700259383264 0.452533928045801 1.38160601008898 0.454545454545455 8.1 8 1 aberrant origin of the right subclavian artery 0.110700259383264 0.452533928045801 1.38160601008898 0.454545454545455 8.1 8 1 abnormal brain ependyma motile cilium morphology 0.110700259383264 0.452533928045801 1.38160601008898 0.454545454545455 8.1 8 1 thin hypoglossal nerve 0.110700259383264 0.452533928045801 1.38160601008898 0.454545454545455 8.1 8 1 abnormal myocardial fiber morphology 7.85585496163102e-06 0.000260552522894095 1.37875733790323 0.45360824742268 8.1 8 1 kyphosis 3.19257111985634e-08 1.78461138441408e-06 1.37792172739541 0.453333333333333 8.1 8 1 increased sacral vertebrae number 0.000270003928904478 0.00526772371097953 1.37728849130745 0.453125 8.1 8 1 decreased body length 1.05415455063428e-13 1.58921784527441e-11 1.37555518084772 0.452554744525547 8.1 8 1 lethality throughout fetal growth and development, incomplete penetrance 1.81430512039435e-09 1.28945256770884e-07 1.3754312346249 0.452513966480447 8.1 8 1 postnatal lethality 7.7109534386203e-09 4.85594852621974e-07 1.37328308231736 0.451807228915663 8.1 8 1 abnormal eyelid morphology 0.0105194978042022 0.100065968596379 1.37269242292712 0.451612903225806 8.1 8 1 abnormal retinal photoreceptor layer morphology 0.0105194978042022 0.100065968596379 1.37269242292712 0.451612903225806 8.1 8 1 abnormal ovary morphology 0.000150756895686251 0.00327517710060741 1.36993046634175 0.450704225352113 8.1 8 1 abnormal skeletal muscle fiber morphology 0.000150756895686251 0.00327517710060741 1.36993046634175 0.450704225352113 8.1 8 1 prenatal lethality, incomplete penetrance 8.34625427261118e-15 1.53787462986076e-12 1.36978964289743 0.450657894736842 8.1 8 1 abnormal cell proliferation 0.0385465030162813 0.243980728379134 1.36778994998809 0.45 8.1 8 1 abnormal vascular regression 0.0385465030162813 0.243980728379134 1.36778994998809 0.45 8.1 8 1 abnormal circulating enzyme level 0.0385465030162813 0.243980728379134 1.36778994998809 0.45 8.1 8 1 increased urine glucose level 0.0385465030162813 0.243980728379134 1.36778994998809 0.45 8.1 8 1 abnormal dopamine level 0.0385465030162813 0.243980728379134 1.36778994998809 0.45 8.1 8 1 kidney atrophy 0.0385465030162813 0.243980728379134 1.36778994998809 0.45 8.1 8 1 abnormal response to tactile stimuli 0.0385465030162813 0.243980728379134 1.36778994998809 0.45 8.1 8 1 enhanced behavioral response to xenobiotic 0.0385465030162813 0.243980728379134 1.36778994998809 0.45 8.1 8 1 polydactyly 1.08572986216788e-05 0.000348484262211947 1.36468838547565 0.448979591836735 8.1 8 1 blood in lymph vessels 0.01449582377438 0.124306572171089 1.36254937546707 0.448275862068966 8.1 8 1 embryonic lethality before implantation, complete penetrance 8.04349502514457e-07 3.44968859914605e-05 1.3617108835437 0.448 8.1 8 1 persistence of hyaloid vascular system 0.00565611277290656 0.0632643339215706 1.35979117835074 0.447368421052632 8.1 8 1 enhanced long term potentiation 0.000912677736659029 0.0148682887397988 1.35693447419454 0.446428571428571 8.1 8 1 hydrops fetalis 0.000207408476712482 0.00426387261010164 1.35090365430923 0.444444444444444 8.1 8 1 abnormal uterus morphology 0.00773894019358462 0.080715361557827 1.35090365430923 0.444444444444444 8.1 8 1 abnormal megakaryocyte differentiation 0.0540089777325006 0.299882437744632 1.35090365430923 0.444444444444444 8.1 8 1 abnormal heart shape 0.0540089777325006 0.299882437744632 1.35090365430923 0.444444444444444 8.1 8 1 right pulmonary isomerism 0.0540089777325006 0.299882437744632 1.35090365430923 0.444444444444444 8.1 8 1 abnormal retinal rod cell morphology 0.0540089777325006 0.299882437744632 1.35090365430923 0.444444444444444 8.1 8 1 increased circulating glycerol level 0.0540089777325006 0.299882437744632 1.35090365430923 0.444444444444444 8.1 8 1 jerky movement 0.0540089777325006 0.299882437744632 1.35090365430923 0.444444444444444 8.1 8 1 decreased lactate dehydrogenase level 0.0540089777325006 0.299882437744632 1.35090365430923 0.444444444444444 8.1 8 1 decreased pulmonary respiratory rate 0.0540089777325006 0.299882437744632 1.35090365430923 0.444444444444444 8.1 8 1 decreased tumor latency 0.0540089777325006 0.299882437744632 1.35090365430923 0.444444444444444 8.1 8 1 atrioventricular block 0.0540089777325006 0.299882437744632 1.35090365430923 0.444444444444444 8.1 8 1 increased effector memory CD8-positive, alpha-beta T cell number 0.0540089777325006 0.299882437744632 1.35090365430923 0.444444444444444 8.1 8 1 abnormal aerobic respiration 0.0540089777325006 0.299882437744632 1.35090365430923 0.444444444444444 8.1 8 1 abnormal trigeminal nerve morphology 0.0200011530942927 0.152616160497095 1.35090365430923 0.444444444444444 8.1 8 1 decreased circulating fructosamine level 0.0200011530942927 0.152616160497095 1.35090365430923 0.444444444444444 8.1 8 1 thick interventricular septum 0.0200011530942927 0.152616160497095 1.35090365430923 0.444444444444444 8.1 8 1 abnormal suckling behavior 4.79910544325217e-05 0.00123707510778132 1.34706585983676 0.443181818181818 8.1 8 1 abnormal nervous system morphology 0.000115593645270292 0.00264205704496228 1.34662864274496 0.443037974683544 8.1 8 1 perinatal lethality, incomplete penetrance 1.17710059739484e-10 1.08445842074802e-08 1.3449262045114 0.442477876106195 8.1 8 1 liver hypoplasia 0.00167822736841536 0.0246134375991693 1.34440892520197 0.442307692307692 8.1 8 1 abnormal blood circulation 0.00417901437866323 0.04915034641572 1.3430495632958 0.441860465116279 8.1 8 1 abnormal vision 0.010594796906443 0.100398313542007 1.34097053920401 0.441176470588235 8.1 8 1 reduced male fertility 1.59431971914459e-10 1.41638225049006e-08 1.3390014194695 0.440528634361233 8.1 8 1 decreased body weight 2.09664556311915e-51 1.04308116765178e-47 1.338082072776 0.440226171243942 8.1 8 1 increased B cell derived lymphoma incidence 0.00227566552192826 0.0308809975356368 1.33739461776613 0.44 8.1 8 1 testicular atrophy 0.00227566552192826 0.0308809975356368 1.33739461776613 0.44 8.1 8 1 increased cellular sensitivity to ionizing radiation 0.0276368190401541 0.192029573637943 1.33739461776613 0.44 8.1 8 1 impaired conditioned place preference behavior 0.0276368190401541 0.192029573637943 1.33739461776613 0.44 8.1 8 1 abnormal preimplantation embryo development 0.0276368190401541 0.192029573637943 1.33739461776613 0.44 8.1 8 1 increased liver glycogen level 0.0276368190401541 0.192029573637943 1.33739461776613 0.44 8.1 8 1 impaired swimming 0.000509405046530304 0.00918221053075457 1.33555247641935 0.439393939393939 8.1 8 1 thick ventricular wall 0.0056897127588561 0.0633251028530404 1.33442921950058 0.439024390243902 8.1 8 1 postnatal lethality, incomplete penetrance 1.19517123251041e-23 4.95498073478273e-21 1.33247143015272 0.438380281690141 8.1 8 1 abnormal fertility/fecundity 0.000282307821904093 0.00546490822557534 1.33239812479814 0.438356164383562 8.1 8 1 astrocytosis 0.000282307821904093 0.00546490822557534 1.33239812479814 0.438356164383562 8.1 8 1 bradykinesia 0.0145131126719479 0.124306572171089 1.32979578471065 0.4375 8.1 8 1 abnormal serotonin level 0.0145131126719479 0.124306572171089 1.32979578471065 0.4375 8.1 8 1 absent mandible 0.0759702336364756 0.35824825814357 1.32979578471065 0.4375 8.1 8 1 disorganized yolk sac vascular plexus 0.0759702336364756 0.35824825814357 1.32979578471065 0.4375 8.1 8 1 increased intestinal adenocarcinoma incidence 0.0759702336364756 0.35824825814357 1.32979578471065 0.4375 8.1 8 1 impaired muscle relaxation 0.0759702336364756 0.35824825814357 1.32979578471065 0.4375 8.1 8 1 small epididymis 0.0759702336364756 0.35824825814357 1.32979578471065 0.4375 8.1 8 1 decreased circulating prolactin level 0.0759702336364756 0.35824825814357 1.32979578471065 0.4375 8.1 8 1 abnormal Langerhans cell physiology 0.0759702336364756 0.35824825814357 1.32979578471065 0.4375 8.1 8 1 decreased liver cholesterol level 0.0759702336364756 0.35824825814357 1.32979578471065 0.4375 8.1 8 1 decreased body size 4.86627491493664e-32 4.03495295030163e-29 1.32551072847635 0.43609022556391 8.1 8 1 abnormal vitelline vasculature morphology 8.59498092611723e-06 0.000283179007333995 1.32153618356337 0.434782608695652 8.1 8 1 abnormal cardiovascular development 0.0382476558347012 0.243980728379134 1.32153618356337 0.434782608695652 8.1 8 1 abnormal hematopoietic stem cell physiology 0.0382476558347012 0.243980728379134 1.32153618356337 0.434782608695652 8.1 8 1 abnormal pancreatic islet morphology 0.00227805549659873 0.0308809975356368 1.31904271906608 0.433962264150943 8.1 8 1 abnormal heart tube morphology 0.0198926126091539 0.152489595886811 1.3171310629515 0.433333333333333 8.1 8 1 kidney cysts 0.000380316543803849 0.00711306317828627 1.3143927447333 0.432432432432432 8.1 8 1 impaired skeletal muscle contractility 0.0105516725821251 0.100180479190978 1.3143927447333 0.432432432432432 8.1 8 1 abnormal circadian rhythm 0.0056715362671398 0.0632643339215706 1.31252570958453 0.431818181818182 8.1 8 1 abnormal photoreceptor outer segment morphology 0.0056715362671398 0.0632643339215706 1.31252570958453 0.431818181818182 8.1 8 1 prenatal lethality, complete penetrance 1.29283154115266e-11 1.46178111755329e-09 1.31202872900536 0.431654676258993 8.1 8 1 abnormal eye morphology 1.53197848798846e-06 6.00125431318313e-05 1.31202872900536 0.431654676258993 8.1 8 1 cochlear inner hair cell degeneration 0.00307765005671625 0.040187162814077 1.31117119388837 0.431372549019608 8.1 8 1 abnormal spermiogenesis 0.00168212437863669 0.0246134375991693 1.31014363025679 0.431034482758621 8.1 8 1 cochlear ganglion degeneration 0.00168212437863669 0.0246134375991693 1.31014363025679 0.431034482758621 8.1 8 1 neonatal lethality, incomplete penetrance 7.11227618620102e-11 6.80453346660579e-09 1.30933738802279 0.430769230769231 8.1 8 1 holoprosencephaly 0.0143716604436941 0.124306572171089 1.30265709522675 0.428571428571429 8.1 8 1 rib bifurcation 0.0272827785447658 0.191711614774308 1.30265709522675 0.428571428571429 8.1 8 1 premature aging 0.0272827785447658 0.191711614774308 1.30265709522675 0.428571428571429 8.1 8 1 abnormal hormone level 0.0272827785447658 0.191711614774308 1.30265709522675 0.428571428571429 8.1 8 1 abnormal blood flow velocity 0.107363087239934 0.452533928045801 1.30265709522675 0.428571428571429 8.1 8 1 increased lactate dehydrogenase level 0.107363087239934 0.452533928045801 1.30265709522675 0.428571428571429 8.1 8 1 decreased coping response 0.107363087239934 0.452533928045801 1.30265709522675 0.428571428571429 8.1 8 1 intestinal obstruction 0.107363087239934 0.452533928045801 1.30265709522675 0.428571428571429 8.1 8 1 abnormal imprinting 0.107363087239934 0.452533928045801 1.30265709522675 0.428571428571429 8.1 8 1 enlarged stomach 0.107363087239934 0.452533928045801 1.30265709522675 0.428571428571429 8.1 8 1 decreased CNS synapse formation 0.107363087239934 0.452533928045801 1.30265709522675 0.428571428571429 8.1 8 1 spina bifida occulta 0.107363087239934 0.452533928045801 1.30265709522675 0.428571428571429 8.1 8 1 abnormal vitelline vein topology 0.107363087239934 0.452533928045801 1.30265709522675 0.428571428571429 8.1 8 1 increased thermal nociceptive threshold 0.000117082478855807 0.00265975037583398 1.30265709522675 0.428571428571429 8.1 8 1 increased sarcoma incidence 0.00415659258367074 0.0490768629727407 1.30265709522675 0.428571428571429 8.1 8 1 trunk curl 0.0530241685752634 0.299882437744632 1.30265709522675 0.428571428571429 8.1 8 1 decreased cochlear outer hair cell number 0.0530241685752634 0.299882437744632 1.30265709522675 0.428571428571429 8.1 8 1 increased keratinocyte proliferation 0.0530241685752634 0.299882437744632 1.30265709522675 0.428571428571429 8.1 8 1 increased muscle cell glucose uptake 0.0530241685752634 0.299882437744632 1.30265709522675 0.428571428571429 8.1 8 1 male infertility 1.13376769904032e-18 2.82024715136279e-16 1.29316125159024 0.42544731610338 8.1 8 1 head bobbing 0.0104172599750772 0.0995168536913966 1.2918016194332 0.425 8.1 8 1 dextrocardia 0.0195753414504931 0.151457735172944 1.28949894274972 0.424242424242424 8.1 8 1 increased osteoblast cell number 0.0195753414504931 0.151457735172944 1.28949894274972 0.424242424242424 8.1 8 1 increased body weight 4.96284769224723e-09 3.20651522973116e-07 1.28908775048481 0.424107142857143 8.1 8 1 abnormal snout morphology 0.00410389336147021 0.0486115939840816 1.28595636323667 0.423076923076923 8.1 8 1 abnormal nasal bone morphology 0.0374408597227831 0.242221426685105 1.28595636323667 0.423076923076923 8.1 8 1 heart inflammation 0.0374408597227831 0.242221426685105 1.28595636323667 0.423076923076923 8.1 8 1 decreased liver weight 0.000907803881729598 0.0148682887397988 1.28430981219539 0.422535211267606 8.1 8 1 thin ventricular wall 0.000206617936573895 0.00426387261010164 1.28335847159377 0.422222222222222 8.1 8 1 oxidative stress 0.000206617936573895 0.00426387261010164 1.28335847159377 0.422222222222222 8.1 8 1 cardiomyopathy 0.00757267516214692 0.0794811369866686 1.28335847159377 0.422222222222222 8.1 8 1 decreased total body fat amount 1.68619747529375e-12 2.04605669258205e-10 1.28315624050779 0.422155688622754 8.1 8 1 increased bone mineral content 4.78541761228404e-05 0.00123707510778132 1.28273879101839 0.422018348623853 8.1 8 1 decreased circulating LDL cholesterol level 0.00164788456991758 0.024327079333353 1.28230307811384 0.421875 8.1 8 1 premature death 7.25965417151863e-30 4.01297550036724e-27 1.28147567904421 0.421602787456446 8.1 8 1 postnatal growth retardation 1.44180364551069e-21 4.48310821025979e-19 1.28137184857272 0.42156862745098 8.1 8 1 increased hepatocellular carcinoma incidence 0.00300621064477492 0.039357626204619 1.27980346197716 0.421052631578947 8.1 8 1 abnormal retinal outer nuclear layer morphology 0.0141120797161021 0.124306572171089 1.27980346197716 0.421052631578947 8.1 8 1 kyphoscoliosis 0.0736490612841044 0.35816625600041 1.27980346197716 0.421052631578947 8.1 8 1 decreased tumor incidence 0.0736490612841044 0.35816625600041 1.27980346197716 0.421052631578947 8.1 8 1 abnormal neurotransmitter level 0.0736490612841044 0.35816625600041 1.27980346197716 0.421052631578947 8.1 8 1 increased susceptibility to ischemic brain injury 0.0736490612841044 0.35816625600041 1.27980346197716 0.421052631578947 8.1 8 1 abnormal optic vesicle formation 0.0736490612841044 0.35816625600041 1.27980346197716 0.421052631578947 8.1 8 1 eyelids fail to open 0.0736490612841044 0.35816625600041 1.27980346197716 0.421052631578947 8.1 8 1 decreased circulating magnesium level 0.0736490612841044 0.35816625600041 1.27980346197716 0.421052631578947 8.1 8 1 abnormal sternum morphology 0.00121319933348307 0.0187443064722927 1.2774849774446 0.420289855072464 8.1 8 1 abnormal postnatal growth/weight/body size 0.02666208441273 0.190559174005671 1.27464296414661 0.419354838709677 8.1 8 1 abnormal nose morphology 0.02666208441273 0.190559174005671 1.27464296414661 0.419354838709677 8.1 8 1 inner cell mass degeneration 0.02666208441273 0.190559174005671 1.27464296414661 0.419354838709677 8.1 8 1 pale kidney 0.02666208441273 0.190559174005671 1.27464296414661 0.419354838709677 8.1 8 1 abnormal mitochondrial ATP synthesis coupled electron transport 0.02666208441273 0.190559174005671 1.27464296414661 0.419354838709677 8.1 8 1 increased circulating HDL cholesterol level 8.43965003610845e-05 0.00200895975739902 1.27370915977727 0.419047619047619 8.1 8 1 decreased circulating total protein level 0.00403054564258771 0.0479712071097461 1.27107752928186 0.418181818181818 8.1 8 1 reduced female fertility 8.30003706623082e-09 5.16158555056229e-07 1.27083932134909 0.418103448275862 8.1 8 1 abnormal digestive system morphology 0.0514098644693702 0.297287740190782 1.2664721759149 0.416666666666667 8.1 8 1 abnormal foregut morphology 0.0514098644693702 0.297287740190782 1.2664721759149 0.416666666666667 8.1 8 1 blindness 0.0514098644693702 0.297287740190782 1.2664721759149 0.416666666666667 8.1 8 1 prolonged QT interval 0.0514098644693702 0.297287740190782 1.2664721759149 0.416666666666667 8.1 8 1 abnormal retinal ganglion layer morphology 0.0514098644693702 0.297287740190782 1.2664721759149 0.416666666666667 8.1 8 1 increased body temperature 0.0514098644693702 0.297287740190782 1.2664721759149 0.416666666666667 8.1 8 1 abnormal truncus arteriosus septation 0.0514098644693702 0.297287740190782 1.2664721759149 0.416666666666667 8.1 8 1 amyloidosis 0.152594899544868 0.553788367575443 1.2664721759149 0.416666666666667 8.1 8 1 mesocardia 0.152594899544868 0.553788367575443 1.2664721759149 0.416666666666667 8.1 8 1 abnormal enteric nervous system morphology 0.152594899544868 0.553788367575443 1.2664721759149 0.416666666666667 8.1 8 1 myocarditis 0.152594899544868 0.553788367575443 1.2664721759149 0.416666666666667 8.1 8 1 abnormal tracheal ciliated epithelium morphology 0.152594899544868 0.553788367575443 1.2664721759149 0.416666666666667 8.1 8 1 abnormal corticospinal tract morphology 0.152594899544868 0.553788367575443 1.2664721759149 0.416666666666667 8.1 8 1 abnormal gastrocnemius morphology 0.152594899544868 0.553788367575443 1.2664721759149 0.416666666666667 8.1 8 1 increased fear-related response 0.152594899544868 0.553788367575443 1.2664721759149 0.416666666666667 8.1 8 1 abnormal somatic nervous system physiology 0.152594899544868 0.553788367575443 1.2664721759149 0.416666666666667 8.1 8 1 decreased renal glomerular filtration rate 0.152594899544868 0.553788367575443 1.2664721759149 0.416666666666667 8.1 8 1 hydrometra 0.152594899544868 0.553788367575443 1.2664721759149 0.416666666666667 8.1 8 1 abnormal respiratory motile cilium morphology 0.152594899544868 0.553788367575443 1.2664721759149 0.416666666666667 8.1 8 1 abnormal colon goblet cell morphology 0.152594899544868 0.553788367575443 1.2664721759149 0.416666666666667 8.1 8 1 abnormal vitelline vein connection 0.152594899544868 0.553788367575443 1.2664721759149 0.416666666666667 8.1 8 1 scaly skin 0.0137659392532337 0.122295621044353 1.26029426286166 0.414634146341463 8.1 8 1 postnatal lethality, complete penetrance 3.47864983340158e-13 4.55428497925602e-11 1.25991014391534 0.414507772020725 8.1 8 1 abnormal bone structure 2.46943541809209e-07 1.19276128203962e-05 1.25991014391534 0.414507772020725 8.1 8 1 increased blood urea nitrogen level 7.84886626219802e-06 0.000260552522894095 1.25773788504652 0.413793103448276 8.1 8 1 focal hair loss 0.0363088642650383 0.235832169089556 1.25773788504652 0.413793103448276 8.1 8 1 decreased trophoblast giant cell number 0.0363088642650383 0.235832169089556 1.25773788504652 0.413793103448276 8.1 8 1 enlarged epididymis 0.0363088642650383 0.235832169089556 1.25773788504652 0.413793103448276 8.1 8 1 polychromatophilia 0.0363088642650383 0.235832169089556 1.25773788504652 0.413793103448276 8.1 8 1 decreased cardiac muscle contractility 0.000145545943940209 0.00318982850705965 1.25673008225402 0.413461538461538 8.1 8 1 embryonic lethality during organogenesis, incomplete penetrance 2.41459450645352e-08 1.39681484530305e-06 1.25545937438521 0.41304347826087 8.1 8 1 abnormal lung development 0.000632456386640837 0.0108429164025384 1.25157250325708 0.411764705882353 8.1 8 1 increased lung adenocarcinoma incidence 0.00722733842509768 0.0766652636777419 1.25157250325708 0.411764705882353 8.1 8 1 small lung 0.00722733842509768 0.0766652636777419 1.25157250325708 0.411764705882353 8.1 8 1 abnormal vagus nerve morphology 0.102507258972371 0.445003153043233 1.25157250325708 0.411764705882353 8.1 8 1 abnormal tarsal bone morphology 0.102507258972371 0.445003153043233 1.25157250325708 0.411764705882353 8.1 8 1 increased circulating magnesium level 0.102507258972371 0.445003153043233 1.25157250325708 0.411764705882353 8.1 8 1 increased hepatoma incidence 0.102507258972371 0.445003153043233 1.25157250325708 0.411764705882353 8.1 8 1 increased trabecular bone mass 0.102507258972371 0.445003153043233 1.25157250325708 0.411764705882353 8.1 8 1 decreased body fat mass 0.102507258972371 0.445003153043233 1.25157250325708 0.411764705882353 8.1 8 1 abnormal coat/hair pigmentation 0.000105414817570284 0.00245064821220637 1.24837971625897 0.410714285714286 8.1 8 1 abnormal heart ventricle morphology 0.00113851176741739 0.0177557869683433 1.24698798859313 0.41025641025641 8.1 8 1 absent gastric milk in neonates 0.00113851176741739 0.0177557869683433 1.24698798859313 0.41025641025641 8.1 8 1 failure of heart looping 0.0185394252335637 0.146635358564355 1.24698798859313 0.41025641025641 8.1 8 1 pale yolk sac 0.000837620451690667 0.0139516100621161 1.24510999463441 0.409638554216867 8.1 8 1 lethality, incomplete penetrance 0.0133577636851398 0.12033892281494 1.24344540908008 0.409090909090909 8.1 8 1 abnormal abdominal fat pad morphology 0.0706242591969446 0.346163240891428 1.24344540908008 0.409090909090909 8.1 8 1 abnormal retinal layer morphology 0.0706242591969446 0.346163240891428 1.24344540908008 0.409090909090909 8.1 8 1 prolonged PR interval 0.0706242591969446 0.346163240891428 1.24344540908008 0.409090909090909 8.1 8 1 decreased bone mineral content 2.22540068746639e-07 1.08542827648483e-05 1.24211694176269 0.408653846153846 8.1 8 1 lethargy 0.00045484009058064 0.00828875256644206 1.24195981121977 0.408602150537634 8.1 8 1 increased circulating free fatty acid level 0.00205590543790528 0.0288659897187146 1.24149948512221 0.408450704225352 8.1 8 1 increased circulating LDL cholesterol level 0.00966380971452676 0.0943555581407905 1.24062580497786 0.408163265306122 8.1 8 1 polyphagia 0.0070150344116781 0.0759101337736693 1.23832834978346 0.407407407407407 8.1 8 1 abnormal trigeminal ganglion morphology 0.0494306580298703 0.289655504945353 1.23832834978346 0.407407407407407 8.1 8 1 edema 2.94939612069812e-06 0.000109692765692977 1.23701933461455 0.406976744186047 8.1 8 1 abnormal heart morphology 6.69172934527615e-08 3.54230227051576e-06 1.23686633284156 0.406926406926407 8.1 8 1 small spleen 0.000600401852487215 0.010554767548141 1.23585416726641 0.406593406593407 8.1 8 1 increased grip strength 0.000600401852487215 0.010554767548141 1.23585416726641 0.406593406593407 8.1 8 1 abnormal lymphatic vessel morphology 0.0349745387616861 0.235451055939633 1.23481037151703 0.40625 8.1 8 1 abnormal spongiotrophoblast layer morphology 0.0349745387616861 0.235451055939633 1.23481037151703 0.40625 8.1 8 1 pancreatic islet hyperplasia 0.0349745387616861 0.235451055939633 1.23481037151703 0.40625 8.1 8 1 perimembraneous ventricular septal defect 0.00272499785837024 0.0361516382543786 1.23343377132582 0.405797101449275 8.1 8 1 small seminiferous tubules 0.00199624416938412 0.0282943439962564 1.23224319818747 0.405405405405405 8.1 8 1 increased circulating phosphate level 0.0249440758445706 0.185773618752603 1.23224319818747 0.405405405405405 8.1 8 1 decreased circulating chloride level 0.0249440758445706 0.185773618752603 1.23224319818747 0.405405405405405 8.1 8 1 abnormal chromosome morphology 0.0249440758445706 0.185773618752603 1.23224319818747 0.405405405405405 8.1 8 1 abnormal calcium ion homeostasis 0.0249440758445706 0.185773618752603 1.23224319818747 0.405405405405405 8.1 8 1 increased trabecular bone volume 0.0249440758445706 0.185773618752603 1.23224319818747 0.405405405405405 8.1 8 1 abnormal hepatocyte morphology 0.000178234792654747 0.00375728005702274 1.23224319818747 0.405405405405405 8.1 8 1 enlarged heart 8.53044437249221e-08 4.42072507845299e-06 1.23153501244139 0.405172413793103 8.1 8 1 abnormal visceral yolk sac morphology 0.00146470112494427 0.0220814790805993 1.23120333050968 0.40506329113924 8.1 8 1 abnormal eye electrophysiology 9.75357303594865e-05 0.00229971686511112 1.23088535444291 0.40495867768595 8.1 8 1 abnormal muscle morphology 0.0178993616503219 0.14362794227476 1.23028725660305 0.404761904761905 8.1 8 1 cleft palate 5.34963518176031e-05 0.00136484282201321 1.22973481508683 0.404580152671756 8.1 8 1 decreased circulating cholesterol level 2.07966418144656e-06 7.89796129976841e-05 1.22910086580594 0.404371584699454 8.1 8 1 small testis 9.99405443892823e-09 6.06346595532536e-07 1.22242096979612 0.402173913043478 8.1 8 1 cyanosis 1.9056809910201e-06 7.4068460393164e-05 1.21897946931809 0.401041666666667 8.1 8 1 abnormal retina morphology 7.60412218361685e-07 3.28960937943425e-05 1.2158132888783 0.4 8.1 8 1 circling 0.00137202441912167 0.0208740718199704 1.2158132888783 0.4 8.1 8 1 impaired fertilization 0.003483688064775 0.0442126227608562 1.2158132888783 0.4 8.1 8 1 increased circulating calcium level 0.00900469359107171 0.0923486517889583 1.2158132888783 0.4 8.1 8 1 increased circulating chloride level 0.0124272540478195 0.114069352191701 1.2158132888783 0.4 8.1 8 1 decreased oocyte number 0.0124272540478195 0.114069352191701 1.2158132888783 0.4 8.1 8 1 irregular heartbeat 0.0172144893671352 0.138355548629237 1.2158132888783 0.4 8.1 8 1 mandible hypoplasia 0.0672585614221809 0.337625837316259 1.2158132888783 0.4 8.1 8 1 abnormal sperm mitochondrial sheath morphology 0.0970507667959866 0.440490599298943 1.2158132888783 0.4 8.1 8 1 decreased muscle cell glucose uptake 0.0970507667959866 0.440490599298943 1.2158132888783 0.4 8.1 8 1 decreased hepatocyte number 0.142984760499078 0.553788367575443 1.2158132888783 0.4 8.1 8 1 abnormal prostate gland morphology 0.142984760499078 0.553788367575443 1.2158132888783 0.4 8.1 8 1 increased alcohol consumption 0.142984760499078 0.553788367575443 1.2158132888783 0.4 8.1 8 1 abnormal ear development 0.142984760499078 0.553788367575443 1.2158132888783 0.4 8.1 8 1 abnormal neurotransmitter secretion 0.142984760499078 0.553788367575443 1.2158132888783 0.4 8.1 8 1 abnormal cerebral aqueduct morphology 0.142984760499078 0.553788367575443 1.2158132888783 0.4 8.1 8 1 abnormal Muller cell morphology 0.142984760499078 0.553788367575443 1.2158132888783 0.4 8.1 8 1 perinatal lethality, complete penetrance 7.36736538866769e-07 3.21514410601945e-05 1.21295926707343 0.39906103286385 8.1 8 1 increased insulin sensitivity 4.72609244387168e-05 0.00123707510778132 1.21156219346265 0.398601398601399 8.1 8 1 hypoglycemia 0.00097379928435608 0.0155277289733061 1.20927665829294 0.397849462365591 8.1 8 1 abnormal lipid level 0.00180279390619864 0.0260723828004018 1.20848911243928 0.397590361445783 8.1 8 1 increased circulating alanine transaminase level 0.00245800561166921 0.0331397775557028 1.2080196139496 0.397435897435897 8.1 8 1 abnormal seminiferous tubule morphology 4.56868823384964e-05 0.00120260444250804 1.20748580059832 0.397260273972603 8.1 8 1 decreased bone marrow cell number 0.0033567900629564 0.043041315884557 1.20748580059832 0.397260273972603 8.1 8 1 increased circulating aspartate transaminase level 0.00629706678331883 0.0696175716600248 1.20616397706181 0.396825396825397 8.1 8 1 abnormal enzyme/coenzyme level 0.00865527302635927 0.0889669076573086 1.20533213983625 0.396551724137931 8.1 8 1 retinal degeneration 0.000938707258263906 0.0150162977809097 1.20314856711916 0.395833333333333 8.1 8 1 hemorrhage 3.57149076616355e-07 1.67624212845884e-05 1.20287910495407 0.395744680851064 8.1 8 1 impaired glucose tolerance 1.91254512220126e-07 9.42070493361512e-06 1.20110587006123 0.395161290322581 8.1 8 1 incomplete somite formation 0.0320084211457457 0.219947369060891 1.19981574560359 0.394736842105263 8.1 8 1 decreased threshold for auditory brainstem response 0.0320084211457457 0.219947369060891 1.19981574560359 0.394736842105263 8.1 8 1 single kidney 0.0449840170139616 0.280445469479272 1.19739187541045 0.393939393939394 8.1 8 1 head tossing 0.0449840170139616 0.280445469479272 1.19739187541045 0.393939393939394 8.1 8 1 cardiovascular system phenotype 0.0449840170139616 0.280445469479272 1.19739187541045 0.393939393939394 8.1 8 1 anemia 1.95663357447461e-06 7.54593180853578e-05 1.19564576986847 0.393364928909953 8.1 8 1 shortened head 0.0637616388731731 0.323357954530108 1.19410233729119 0.392857142857143 8.1 8 1 small superior cervical ganglion 0.0637616388731731 0.323357954530108 1.19410233729119 0.392857142857143 8.1 8 1 abnormal ovulation 0.0637616388731731 0.323357954530108 1.19410233729119 0.392857142857143 8.1 8 1 prolonged QRS complex duration 0.0637616388731731 0.323357954530108 1.19410233729119 0.392857142857143 8.1 8 1 abnormal placenta morphology 0.00309951475934575 0.040366717088338 1.19272822643125 0.392405063291139 8.1 8 1 increased kidney weight 0.0157820383205432 0.12913756684984 1.19197381262579 0.392156862745098 8.1 8 1 thymus hypoplasia 0.000130764277515639 0.0029172748010776 1.18938256520704 0.391304347826087 8.1 8 1 abnormal testis morphology 0.000454305628899302 0.00828875256644206 1.18938256520704 0.391304347826087 8.1 8 1 decreased spleen weight 0.00579338358741489 0.0643350074718506 1.18938256520704 0.391304347826087 8.1 8 1 abnormal cranial nerve morphology 0.0914377899298155 0.420039709049706 1.18938256520704 0.391304347826087 8.1 8 1 conjunctivitis 0.0914377899298155 0.420039709049706 1.18938256520704 0.391304347826087 8.1 8 1 abnormal chondrocyte physiology 0.0914377899298155 0.420039709049706 1.18938256520704 0.391304347826087 8.1 8 1 respiratory failure 6.9073327406514e-05 0.00170118714775944 1.18763218615596 0.390728476821192 8.1 8 1 decreased caudal vertebrae number 0.0079448546322817 0.0825170183624247 1.18731766492022 0.390625 8.1 8 1 abnormal thoracic vertebrae morphology 0.0109224005691215 0.10291466445337 1.18490278153394 0.389830508474576 8.1 8 1 short snout 0.000799971764471056 0.0135369371708963 1.18204069752057 0.388888888888889 8.1 8 1 abnormal cell adhesion 0.0150596513874523 0.124306572171089 1.18204069752057 0.388888888888889 8.1 8 1 abnormal reflex 0.0426933208417377 0.267168894575654 1.18204069752057 0.388888888888889 8.1 8 1 renal hypoplasia 0.0426933208417377 0.267168894575654 1.18204069752057 0.388888888888889 8.1 8 1 head tilt 0.0426933208417377 0.267168894575654 1.18204069752057 0.388888888888889 8.1 8 1 lowered ear position 0.133369801579561 0.529963868097697 1.18204069752057 0.388888888888889 8.1 8 1 underdeveloped hair follicles 0.133369801579561 0.529963868097697 1.18204069752057 0.388888888888889 8.1 8 1 abnormal mammary gland morphology 0.133369801579561 0.529963868097697 1.18204069752057 0.388888888888889 8.1 8 1 absent spleen 0.133369801579561 0.529963868097697 1.18204069752057 0.388888888888889 8.1 8 1 decreased activity of thyroid 0.133369801579561 0.529963868097697 1.18204069752057 0.388888888888889 8.1 8 1 darkened coat color 0.133369801579561 0.529963868097697 1.18204069752057 0.388888888888889 8.1 8 1 abnormal glycogen homeostasis 0.133369801579561 0.529963868097697 1.18204069752057 0.388888888888889 8.1 8 1 abnormal kidney morphology 2.50697661774799e-05 0.000725128411238155 1.18107576633892 0.388571428571429 8.1 8 1 increased total body fat amount 0.000219768586797459 0.0044626478339484 1.17952035488194 0.388059701492537 8.1 8 1 abnormal retinal pigment epithelium morphology 0.00387809733422686 0.0477200616868018 1.17781912360086 0.3875 8.1 8 1 prenatal lethality 0.0104217649795412 0.0995168536913966 1.1765935053661 0.387096774193548 8.1 8 1 small cranium 0.0602578410606158 0.312991717174029 1.1765935053661 0.387096774193548 8.1 8 1 decreased leukocyte cell number 0.000210678870699651 0.00429560402348673 1.17587781588595 0.386861313868613 8.1 8 1 delayed bone ossification 0.00529535609170289 0.0596027071407734 1.17528617924903 0.386666666666667 8.1 8 1 decreased blood urea nitrogen level 0.028948488670941 0.200304215769029 1.17436510857563 0.386363636363636 8.1 8 1 abnormal spermatogenesis 2.21351512715478e-05 0.000651611701632841 1.17286336291249 0.385869565217391 8.1 8 1 domed cranium 0.00724365752023534 0.076674885453555 1.17239138570408 0.385714285714286 8.1 8 1 abnormal cornea morphology 0.00505271385883217 0.0577867849372185 1.16905123930606 0.384615384615385 8.1 8 1 increased susceptibility to injury 0.0198062994177737 0.152171766415383 1.16905123930606 0.384615384615385 8.1 8 1 abnormal circulating hormone level 0.0404265435908594 0.254584878942438 1.16905123930606 0.384615384615385 8.1 8 1 increased leukemia incidence 0.0858946249843043 0.397142898974827 1.16905123930606 0.384615384615385 8.1 8 1 abnormal Mullerian duct morphology 0.0858946249843043 0.397142898974827 1.16905123930606 0.384615384615385 8.1 8 1 absent common myeloid progenitor cells 0.199883882306897 0.616704791023923 1.16905123930606 0.384615384615385 8.1 8 1 abnormal renal/urinary system morphology 0.199883882306897 0.616704791023923 1.16905123930606 0.384615384615385 8.1 8 1 lymphoid hypoplasia 0.199883882306897 0.616704791023923 1.16905123930606 0.384615384615385 8.1 8 1 abnormal bile duct development 0.199883882306897 0.616704791023923 1.16905123930606 0.384615384615385 8.1 8 1 abnormal soleus morphology 0.199883882306897 0.616704791023923 1.16905123930606 0.384615384615385 8.1 8 1 abnormal dopaminergic neuron morphology 0.199883882306897 0.616704791023923 1.16905123930606 0.384615384615385 8.1 8 1 abnormal insulin secretion 0.199883882306897 0.616704791023923 1.16905123930606 0.384615384615385 8.1 8 1 abnormal vestibulocochlear ganglion morphology 0.199883882306897 0.616704791023923 1.16905123930606 0.384615384615385 8.1 8 1 vestibular hair cell degeneration 0.199883882306897 0.616704791023923 1.16905123930606 0.384615384615385 8.1 8 1 small interparietal bone 0.199883882306897 0.616704791023923 1.16905123930606 0.384615384615385 8.1 8 1 increased cochlear inner hair cell number 0.199883882306897 0.616704791023923 1.16905123930606 0.384615384615385 8.1 8 1 decreased endocochlear potential 0.199883882306897 0.616704791023923 1.16905123930606 0.384615384615385 8.1 8 1 hyperalgesia 0.199883882306897 0.616704791023923 1.16905123930606 0.384615384615385 8.1 8 1 increased circulating thyroxine level 0.199883882306897 0.616704791023923 1.16905123930606 0.384615384615385 8.1 8 1 increased mean corpuscular hemoglobin 0.00182616802233279 0.0263338722061033 1.1666895196307 0.383838383838384 8.1 8 1 muscular ventricular septal defect 0.0136435036635509 0.121424741907273 1.16515440184171 0.383333333333333 8.1 8 1 no abnormal phenotype detected 6.04498424433276e-38 1.00245988718518e-34 1.16500841081278 0.38328530259366 8.1 8 1 decreased lymphocyte cell number 0.000474357041871453 0.00858155012112902 1.16357131162181 0.3828125 8.1 8 1 decreased heart weight 0.00481585638210518 0.0553322990784602 1.16327814676628 0.382716049382716 8.1 8 1 decreased erythrocyte cell number 0.000125423262341346 0.00282344221786514 1.16160505306844 0.382165605095541 8.1 8 1 increased sensitivity to xenobiotic induced morbidity/mortality 0.00122717796210208 0.0189015800664329 1.16054904847475 0.381818181818182 8.1 8 1 increased heart weight 0.000320716922578847 0.00613679496088371 1.15895871062141 0.381294964028777 8.1 8 1 decreased susceptibility to hepatic steatosis 0.0129600407926012 0.117657304640859 1.15791741797934 0.380952380952381 8.1 8 1 abnormal reproductive system morphology 0.0382133540471346 0.243980728379134 1.15791741797934 0.380952380952381 8.1 8 1 abnormal eye pigmentation 0.12414405800874 0.498510374696687 1.15791741797934 0.380952380952381 8.1 8 1 liver degeneration 0.12414405800874 0.498510374696687 1.15791741797934 0.380952380952381 8.1 8 1 increased circulating cholesterol level 6.0507513836668e-05 0.00150512440668712 1.15709503344952 0.380681818181818 8.1 8 1 decreased double-positive T cell number 0.00225186751183978 0.0307775848115464 1.15502262443439 0.38 8.1 8 1 abnormal interventricular septum morphology 0.0259897271895123 0.189241969090996 1.15502262443439 0.38 8.1 8 1 increased body length 0.0259897271895123 0.189241969090996 1.15502262443439 0.38 8.1 8 1 kidney inflammation 0.0259897271895123 0.189241969090996 1.15502262443439 0.38 8.1 8 1 abnormal myocardium layer morphology 0.00624855004219124 0.0692350477948807 1.15425312235282 0.379746835443038 8.1 8 1 abnormal spinal nerve morphology 0.0805383344670334 0.374465620535973 1.15292639462598 0.379310344827586 8.1 8 1 increased retinal apoptosis 0.0805383344670334 0.374465620535973 1.15292639462598 0.379310344827586 8.1 8 1 pale liver 0.00852760151021419 0.0878360611041731 1.15009365164164 0.378378378378378 8.1 8 1 abnormal branching of the mammary ductal tree 0.0534972091008828 0.299882437744632 1.15009365164164 0.378378378378378 8.1 8 1 trabecula carnea hypoplasia 0.0360727025339661 0.235832169089556 1.14826810616284 0.377777777777778 8.1 8 1 cardiac hypertrophy 0.00290471534753986 0.0381291790343293 1.14757886960452 0.377551020408163 8.1 8 1 azoospermia 0.000188046757012959 0.00393737286299939 1.14699366875312 0.377358490566038 8.1 8 1 increased circulating bilirubin level 0.0245790934708446 0.184435882379264 1.14699366875312 0.377358490566038 8.1 8 1 obese 0.00809084803170546 0.0838582686619473 1.1447592655023 0.376623376623377 8.1 8 1 abnormal definitive hematopoiesis 0.00393943345872306 0.0477382532821551 1.14391035243926 0.376344086021505 8.1 8 1 abnormal seminal vesicle morphology 0.0232227913354127 0.174521732467792 1.13982495832341 0.375 8.1 8 1 neonatal lethality, complete penetrance 8.5532640494111e-10 6.86330462029358e-08 1.13982495832341 0.375 8.1 8 1 decreased circulating HDL cholesterol level 0.000914511830025814 0.0148682887397988 1.13982495832341 0.375 8.1 8 1 cochlear outer hair cell degeneration 0.0110430170828986 0.103854461223857 1.13982495832341 0.375 8.1 8 1 curly tail 0.0340162294710908 0.229933072851463 1.13982495832341 0.375 8.1 8 1 thymus atrophy 0.0340162294710908 0.229933072851463 1.13982495832341 0.375 8.1 8 1 polydipsia 0.0754278224399737 0.35824825814357 1.13982495832341 0.375 8.1 8 1 abnormal diaphragm morphology 0.0754278224399737 0.35824825814357 1.13982495832341 0.375 8.1 8 1 abnormal embryonic hematopoiesis 0.0754278224399737 0.35824825814357 1.13982495832341 0.375 8.1 8 1 apnea 0.115454545206083 0.46622269675346 1.13982495832341 0.375 8.1 8 1 abnormal tumor morphology 0.115454545206083 0.46622269675346 1.13982495832341 0.375 8.1 8 1 increased hemangiosarcoma incidence 0.115454545206083 0.46622269675346 1.13982495832341 0.375 8.1 8 1 abnormal tympanic ring morphology 0.18319347661664 0.603567911369393 1.13982495832341 0.375 8.1 8 1 disorganized retinal layers 0.18319347661664 0.603567911369393 1.13982495832341 0.375 8.1 8 1 paternal imprinting 0.18319347661664 0.603567911369393 1.13982495832341 0.375 8.1 8 1 small pancreas 0.18319347661664 0.603567911369393 1.13982495832341 0.375 8.1 8 1 abnormal amnion morphology 0.18319347661664 0.603567911369393 1.13982495832341 0.375 8.1 8 1 impaired behavioral response to addictive substance 0.18319347661664 0.603567911369393 1.13982495832341 0.375 8.1 8 1 decreased fibroblast apoptosis 0.18319347661664 0.603567911369393 1.13982495832341 0.375 8.1 8 1 abnormal liver morphology 0.000109674393045076 0.00252606530277432 1.13770237925763 0.374301675977654 8.1 8 1 abnormal cranium morphology 0.000825739365920437 0.0138785585995073 1.13415418738648 0.373134328358209 8.1 8 1 internal hemorrhage 0.0150986148831538 0.124306572171089 1.13415418738648 0.373134328358209 8.1 8 1 decreased bone mineral density 4.01702925810598e-06 0.000143774968050915 1.13125484585481 0.37218045112782 8.1 8 1 increased oxygen consumption 0.00688219145937868 0.075250335187712 1.13098910593331 0.372093023255814 8.1 8 1 increased circulating creatinine level 0.00688219145937868 0.075250335187712 1.13098910593331 0.372093023255814 8.1 8 1 spleen hypoplasia 0.0031895056912738 0.0414302632221597 1.12896948252985 0.371428571428571 8.1 8 1 ovary cysts 0.0705897291187399 0.346163240891428 1.12896948252985 0.371428571428571 8.1 8 1 decreased triglyceride level 0.0705897291187399 0.346163240891428 1.12896948252985 0.371428571428571 8.1 8 1 diluted coat color 0.0301787652846048 0.208237666145505 1.12575304525769 0.37037037037037 8.1 8 1 decreased tumor growth/size 0.0301787652846048 0.208237666145505 1.12575304525769 0.37037037037037 8.1 8 1 rectal prolapse 0.107344017310442 0.452533928045801 1.12575304525769 0.37037037037037 8.1 8 1 abnormal palate morphology 0.107344017310442 0.452533928045801 1.12575304525769 0.37037037037037 8.1 8 1 enlarged liver 0.00430979933073544 0.0504500039303736 1.12462729221243 0.37 8.1 8 1 decreased percent body fat/body weight 0.0134731216096324 0.12033892281494 1.12421091779843 0.36986301369863 8.1 8 1 decreased circulating glucose level 3.94890932656857e-06 0.000142361042751294 1.12212158382137 0.369175627240143 8.1 8 1 decreased total retina thickness 0.066032335408046 0.334532452805529 1.11982802923002 0.368421052631579 8.1 8 1 enlarged adrenal glands 0.168206900085244 0.562007607739483 1.11982802923002 0.368421052631579 8.1 8 1 small superior vagus ganglion 0.168206900085244 0.562007607739483 1.11982802923002 0.368421052631579 8.1 8 1 shiny skin 0.168206900085244 0.562007607739483 1.11982802923002 0.368421052631579 8.1 8 1 thin dermal layer 0.168206900085244 0.562007607739483 1.11982802923002 0.368421052631579 8.1 8 1 decreased grooming behavior 0.168206900085244 0.562007607739483 1.11982802923002 0.368421052631579 8.1 8 1 abnormal response to novelty 0.168206900085244 0.562007607739483 1.11982802923002 0.368421052631579 8.1 8 1 abnormal sternebra morphology 0.168206900085244 0.562007607739483 1.11982802923002 0.368421052631579 8.1 8 1 abnormal blastocyst morphology 0.168206900085244 0.562007607739483 1.11982802923002 0.368421052631579 8.1 8 1 absent amnion 0.168206900085244 0.562007607739483 1.11982802923002 0.368421052631579 8.1 8 1 decreased eye pigmentation 0.168206900085244 0.562007607739483 1.11982802923002 0.368421052631579 8.1 8 1 decreased liver regeneration 0.168206900085244 0.562007607739483 1.11982802923002 0.368421052631579 8.1 8 1 abnormal craniofacial development 0.0416692732568195 0.261748275824087 1.11656322448008 0.36734693877551 8.1 8 1 decreased circulating creatinine level 0.0416692732568195 0.261748275824087 1.11656322448008 0.36734693877551 8.1 8 1 decreased food intake 0.0120003463309513 0.111800979394163 1.11577801827439 0.367088607594937 8.1 8 1 epidermal hyperplasia 0.0267181147278536 0.190559174005671 1.11449551480511 0.366666666666667 8.1 8 1 intracranial hemorrhage 0.0267181147278536 0.190559174005671 1.11449551480511 0.366666666666667 8.1 8 1 increased metastatic potential 0.0998087727167946 0.440490599298943 1.11449551480511 0.366666666666667 8.1 8 1 abnormal estrous cycle 0.0998087727167946 0.440490599298943 1.11449551480511 0.366666666666667 8.1 8 1 abnormal cellular respiration 0.0998087727167946 0.440490599298943 1.11449551480511 0.366666666666667 8.1 8 1 abnormal mammary gland development 0.0617533667085283 0.314777663293984 1.11202434958381 0.365853658536585 8.1 8 1 thrombocytopenia 0.00102341804307397 0.016234246164619 1.11100179845776 0.36551724137931 8.1 8 1 abnormal placenta vasculature 0.039100258143829 0.246857594245621 1.11059867734076 0.365384615384615 8.1 8 1 decreased kidney weight 0.039100258143829 0.246857594245621 1.11059867734076 0.365384615384615 8.1 8 1 abnormal intestine morphology 0.0163141650710003 0.131331668654088 1.10901887836872 0.364864864864865 8.1 8 1 cardiac fibrosis 0.0106738688309817 0.100955318315844 1.10853564574198 0.364705882352941 8.1 8 1 respiratory distress 0.000412251936245916 0.00768147334390798 1.10688204045279 0.364161849710983 8.1 8 1 hyperglycemia 0.0100626070046945 0.0977763082975689 1.10528480807119 0.363636363636364 8.1 8 1 teratozoospermia 0.0100626070046945 0.0977763082975689 1.10528480807119 0.363636363636364 8.1 8 1 abnormal myelopoiesis 0.0577445237078402 0.312991717174029 1.10528480807119 0.363636363636364 8.1 8 1 abnormal basisphenoid bone morphology 0.154726800186908 0.553788367575443 1.10528480807119 0.363636363636364 8.1 8 1 abnormal enterocyte morphology 0.154726800186908 0.553788367575443 1.10528480807119 0.363636363636364 8.1 8 1 intracerebral hemorrhage 0.154726800186908 0.553788367575443 1.10528480807119 0.363636363636364 8.1 8 1 increased myocardial infarction size 0.154726800186908 0.553788367575443 1.10528480807119 0.363636363636364 8.1 8 1 aphakia 0.154726800186908 0.553788367575443 1.10528480807119 0.363636363636364 8.1 8 1 decreased cardiac output 0.154726800186908 0.553788367575443 1.10528480807119 0.363636363636364 8.1 8 1 parakeratosis 0.154726800186908 0.553788367575443 1.10528480807119 0.363636363636364 8.1 8 1 cleft upper lip 0.154726800186908 0.553788367575443 1.10528480807119 0.363636363636364 8.1 8 1 decreased circulating estradiol level 0.154726800186908 0.553788367575443 1.10528480807119 0.363636363636364 8.1 8 1 abnormal temporal bone morphology 0.154726800186908 0.553788367575443 1.10528480807119 0.363636363636364 8.1 8 1 abnormal sperm midpiece morphology 0.154726800186908 0.553788367575443 1.10528480807119 0.363636363636364 8.1 8 1 pulmonary vascular congestion 0.154726800186908 0.553788367575443 1.10528480807119 0.363636363636364 8.1 8 1 increased circulating creatine kinase level 0.154726800186908 0.553788367575443 1.10528480807119 0.363636363636364 8.1 8 1 rough coat 0.154726800186908 0.553788367575443 1.10528480807119 0.363636363636364 8.1 8 1 increased adenoma incidence 0.154726800186908 0.553788367575443 1.10528480807119 0.363636363636364 8.1 8 1 increased bone volume 0.154726800186908 0.553788367575443 1.10528480807119 0.363636363636364 8.1 8 1 belly spot 0.0928242826834092 0.424839748252034 1.10528480807119 0.363636363636364 8.1 8 1 abnormal ovarian folliculogenesis 0.0928242826834092 0.424839748252034 1.10528480807119 0.363636363636364 8.1 8 1 abnormal QRS complex 0.0928242826834092 0.424839748252034 1.10528480807119 0.363636363636364 8.1 8 1 myeloid hyperplasia 0.0928242826834092 0.424839748252034 1.10528480807119 0.363636363636364 8.1 8 1 abnormal enzyme/coenzyme activity 0.00081984407198722 0.0138261839258862 1.10352480041502 0.363057324840764 8.1 8 1 short tail 0.0136126485764816 0.121367252093183 1.09862646585389 0.36144578313253 8.1 8 1 heart right ventricle hypertrophy 0.0863572642318285 0.398911225212021 1.09760921912625 0.361111111111111 8.1 8 1 decreased heart rate 0.00793266423010908 0.0825170183624247 1.09423195999047 0.36 8.1 8 1 decreased respiratory quotient 0.0504890179196797 0.295162002526917 1.09423195999047 0.36 8.1 8 1 decreased eosinophil cell number 0.0302630705786511 0.208530160843198 1.0923322517266 0.359375 8.1 8 1 increased rib number 0.0184269302810459 0.145977672210515 1.09111449001899 0.358974358974359 8.1 8 1 abnormal heart looping 0.0803715788256704 0.374390079267519 1.09111449001899 0.358974358974359 8.1 8 1 increased hepatocyte apoptosis 0.0803715788256704 0.374390079267519 1.09111449001899 0.358974358974359 8.1 8 1 abnormal blood vessel morphology 0.0018382413046898 0.0264313598000918 1.09003950037365 0.358620689655172 8.1 8 1 enlarged kidney 0.0472150266375557 0.289655504945353 1.08964398531546 0.358490566037736 8.1 8 1 rib fusion 0.0283807857997637 0.196649595200313 1.08878801989102 0.358208955223881 8.1 8 1 decreased white adipose tissue amount 0.0283807857997637 0.196649595200313 1.08878801989102 0.358208955223881 8.1 8 1 abnormal renal tubule epithelium morphology 0.131556449775592 0.526967260574532 1.08554757935563 0.357142857142857 8.1 8 1 abnormal mitotic spindle morphology 0.131556449775592 0.526967260574532 1.08554757935563 0.357142857142857 8.1 8 1 megacephaly 0.251284324010766 0.616704791023923 1.08554757935563 0.357142857142857 8.1 8 1 abnormal kidney blood vessel morphology 0.251284324010766 0.616704791023923 1.08554757935563 0.357142857142857 8.1 8 1 translucent skin 0.251284324010766 0.616704791023923 1.08554757935563 0.357142857142857 8.1 8 1 abnormal olfactory system physiology 0.251284324010766 0.616704791023923 1.08554757935563 0.357142857142857 8.1 8 1 absent otoliths 0.251284324010766 0.616704791023923 1.08554757935563 0.357142857142857 8.1 8 1 abnormal kidney medulla morphology 0.251284324010766 0.616704791023923 1.08554757935563 0.357142857142857 8.1 8 1 abnormal prepulse inhibition 0.251284324010766 0.616704791023923 1.08554757935563 0.357142857142857 8.1 8 1 absent olfactory bulb 0.251284324010766 0.616704791023923 1.08554757935563 0.357142857142857 8.1 8 1 abnormal vascular endothelial cell migration 0.251284324010766 0.616704791023923 1.08554757935563 0.357142857142857 8.1 8 1 vascular smooth muscle hypoplasia 0.251284324010766 0.616704791023923 1.08554757935563 0.357142857142857 8.1 8 1 abnormal sagittal suture morphology 0.251284324010766 0.616704791023923 1.08554757935563 0.357142857142857 8.1 8 1 lysosomal protein accumulation 0.251284324010766 0.616704791023923 1.08554757935563 0.357142857142857 8.1 8 1 premature hair loss 0.251284324010766 0.616704791023923 1.08554757935563 0.357142857142857 8.1 8 1 abnormal viscerocranium morphology 0.251284324010766 0.616704791023923 1.08554757935563 0.357142857142857 8.1 8 1 abnormal glucose tolerance 0.251284324010766 0.616704791023923 1.08554757935563 0.357142857142857 8.1 8 1 decreased cornea thickness 0.251284324010766 0.616704791023923 1.08554757935563 0.357142857142857 8.1 8 1 pulmonary alveolar hemorrhage 0.251284324010766 0.616704791023923 1.08554757935563 0.357142857142857 8.1 8 1 decreased compact bone area 0.251284324010766 0.616704791023923 1.08554757935563 0.357142857142857 8.1 8 1 decreased response to antigen 0.251284324010766 0.616704791023923 1.08554757935563 0.357142857142857 8.1 8 1 abnormal glucose homeostasis 0.000618207471942656 0.010791516396192 1.08554757935563 0.357142857142857 8.1 8 1 hydronephrosis 0.0162659052834449 0.131236889742288 1.08554757935563 0.357142857142857 8.1 8 1 arrest of spermatogenesis 0.0162659052834449 0.131236889742288 1.08554757935563 0.357142857142857 8.1 8 1 disheveled coat 0.0748311515204139 0.35824825814357 1.08554757935563 0.357142857142857 8.1 8 1 abnormal spleen white pulp morphology 0.0748311515204139 0.35824825814357 1.08554757935563 0.357142857142857 8.1 8 1 abnormal pulmonary alveolus morphology 0.00944312284776914 0.0940240907058504 1.08339798018859 0.356435643564356 8.1 8 1 insulin resistance 0.00346382298706815 0.0440729395413403 1.08225804123637 0.356060606060606 8.1 8 1 albuminuria 0.0697013905623915 0.343331106978116 1.08072292344738 0.355555555555556 8.1 8 1 abnormal cell migration 0.0697013905623915 0.343331106978116 1.08072292344738 0.355555555555556 8.1 8 1 abnormal metabolism 0.0697013905623915 0.343331106978116 1.08072292344738 0.355555555555556 8.1 8 1 abnormal bone mineralization 0.00520875130662477 0.0592987133877763 1.08016469879684 0.355371900826446 8.1 8 1 abnormal podocyte morphology 0.121561785127693 0.48969221134435 1.07854404658559 0.354838709677419 8.1 8 1 abnormal placenta labyrinth morphology 0.0219552508810979 0.167270096682178 1.07730291419597 0.354430379746835 8.1 8 1 weight loss 0.00102463382827947 0.016234246164619 1.07686319872078 0.354285714285714 8.1 8 1 increased bone mineral density 0.00739134785311372 0.0780720925036959 1.07594096360912 0.353982300884956 8.1 8 1 female infertility 7.12596633237087e-05 0.00174638830066725 1.07412076273083 0.353383458646617 8.1 8 1 abnormal lung morphology 0.00653850547008569 0.0718080898756652 1.07277643136321 0.352941176470588 8.1 8 1 decreased circulating alanine transaminase level 0.0338337131353432 0.229322510692551 1.07277643136321 0.352941176470588 8.1 8 1 short maxilla 0.112462094425855 0.457855089827029 1.07277643136321 0.352941176470588 8.1 8 1 abnormal retinal photoreceptor morphology 0.112462094425855 0.457855089827029 1.07277643136321 0.352941176470588 8.1 8 1 thin skin 0.112462094425855 0.457855089827029 1.07277643136321 0.352941176470588 8.1 8 1 increased susceptibility to weight gain 0.112462094425855 0.457855089827029 1.07277643136321 0.352941176470588 8.1 8 1 abnormal skin physiology 0.112462094425855 0.457855089827029 1.07277643136321 0.352941176470588 8.1 8 1 hyperlipidemia 0.227204140786241 0.616704791023923 1.07277643136321 0.352941176470588 8.1 8 1 abnormal touch/ nociception 0.227204140786241 0.616704791023923 1.07277643136321 0.352941176470588 8.1 8 1 abnormal duodenum morphology 0.227204140786241 0.616704791023923 1.07277643136321 0.352941176470588 8.1 8 1 aminoaciduria 0.227204140786241 0.616704791023923 1.07277643136321 0.352941176470588 8.1 8 1 abnormal testis development 0.227204140786241 0.616704791023923 1.07277643136321 0.352941176470588 8.1 8 1 abnormal cochlea morphology 0.0564632828005859 0.312463661771874 1.0694653929948 0.351851851851852 8.1 8 1 abnormal maxilla morphology 0.0564632828005859 0.312463661771874 1.0694653929948 0.351851851851852 8.1 8 1 increased brown adipose tissue amount 0.104156460761091 0.450589906336022 1.06794410509581 0.351351351351351 8.1 8 1 increased erythroid progenitor cell number 0.104156460761091 0.450589906336022 1.06794410509581 0.351351351351351 8.1 8 1 absent vitelline blood vessels 0.0526751490384809 0.299882437744632 1.06650288498097 0.350877192982456 8.1 8 1 increased macrophage cell number 0.0526751490384809 0.299882437744632 1.06650288498097 0.350877192982456 8.1 8 1 decreased neutrophil cell number 0.00818802361459535 0.0846890176353677 1.06513557358997 0.35042735042735 8.1 8 1 increased circulating insulin level 0.00237304991133615 0.0320813133393949 1.06383662776852 0.35 8.1 8 1 increased erythrocyte cell number 0.0491586956522796 0.289655504945353 1.06383662776852 0.35 8.1 8 1 decreased circulating phosphate level 0.0965586105385009 0.440310804242935 1.06383662776852 0.35 8.1 8 1 abnormal skin pigmentation 0.0965586105385009 0.440310804242935 1.06383662776852 0.35 8.1 8 1 small gonad 0.206521741087152 0.616704791023923 1.06383662776852 0.35 8.1 8 1 abnormal optic stalk morphology 0.206521741087152 0.616704791023923 1.06383662776852 0.35 8.1 8 1 abnormal induced retinal neovascularization 0.206521741087152 0.616704791023923 1.06383662776852 0.35 8.1 8 1 extramedullary hematopoiesis 0.012366873811585 0.113935550393769 1.06096914359663 0.349056603773585 8.1 8 1 abnormal organ of Corti morphology 0.0895943193492729 0.412714572928364 1.06030228681247 0.348837209302326 8.1 8 1 abnormal homeostasis 0.0895943193492729 0.412714572928364 1.06030228681247 0.348837209302326 8.1 8 1 decreased oxygen consumption 0.0895943193492729 0.412714572928364 1.06030228681247 0.348837209302326 8.1 8 1 abnormal neuron differentiation 0.0108953518855749 0.102854602714868 1.05840888987174 0.348214285714286 8.1 8 1 hydroencephaly 0.0102278475062702 0.098659514109121 1.0572289468507 0.347826086956522 8.1 8 1 abnormal food intake 0.0400356019302628 0.252442483654065 1.0572289468507 0.347826086956522 8.1 8 1 abnormal pulmonary artery morphology 0.18848093899069 0.614757083473411 1.0572289468507 0.347826086956522 8.1 8 1 abnormal innervation pattern to muscle 0.18848093899069 0.614757083473411 1.0572289468507 0.347826086956522 8.1 8 1 abnormal circulating insulin level 0.18848093899069 0.614757083473411 1.0572289468507 0.347826086956522 8.1 8 1 failure of embryo implantation 0.18848093899069 0.614757083473411 1.0572289468507 0.347826086956522 8.1 8 1 abnormal crista ampullaris morphology 0.18848093899069 0.614757083473411 1.0572289468507 0.347826086956522 8.1 8 1 decreased epididymis weight 0.18848093899069 0.614757083473411 1.0572289468507 0.347826086956522 8.1 8 1 dilated heart 0.18848093899069 0.614757083473411 1.0572289468507 0.347826086956522 8.1 8 1 abnormal corneal stroma morphology 0.18848093899069 0.614757083473411 1.0572289468507 0.347826086956522 8.1 8 1 abnormal lens development 0.18848093899069 0.614757083473411 1.0572289468507 0.347826086956522 8.1 8 1 abnormal palatal shelf fusion at midline 0.18848093899069 0.614757083473411 1.0572289468507 0.347826086956522 8.1 8 1 abnormal vertebral artery topology 0.18848093899069 0.614757083473411 1.0572289468507 0.347826086956522 8.1 8 1 decreased hemoglobin content 0.00498238663706908 0.0571137638696283 1.05629168714604 0.347517730496454 8.1 8 1 eyelids open at birth 0.0719001911294504 0.35207032565848 1.05214611537546 0.346153846153846 8.1 8 1 small seminal vesicle 0.172566636078764 0.573492995652538 1.05214611537546 0.346153846153846 8.1 8 1 increased susceptibility to otitis media 0.172566636078764 0.573492995652538 1.05214611537546 0.346153846153846 8.1 8 1 abnormal erythrocyte osmotic lysis 0.172566636078764 0.573492995652538 1.05214611537546 0.346153846153846 8.1 8 1 pulmonary edema 0.172566636078764 0.573492995652538 1.05214611537546 0.346153846153846 8.1 8 1 increased T cell proliferation 0.0144874581418376 0.124306572171089 1.05105354412377 0.345794392523364 8.1 8 1 abnormal platelet physiology 0.0669038185779026 0.337625837316259 1.05002056766763 0.345454545454545 8.1 8 1 increased spleen weight 0.0127420567134936 0.1167435214542 1.04904243951889 0.345132743362832 8.1 8 1 abnormal outer ear morphology 0.158408089411675 0.557431791649567 1.04811490420543 0.344827586206897 8.1 8 1 abnormal embryonic erythropoiesis 0.158408089411675 0.557431791649567 1.04811490420543 0.344827586206897 8.1 8 1 short sternum 0.158408089411675 0.557431791649567 1.04811490420543 0.344827586206897 8.1 8 1 abnormal retinal pigmentation 0.0267586232788823 0.190559174005671 1.04811490420543 0.344827586206897 8.1 8 1 abnormal male meiosis 0.0580256375422203 0.312991717174029 1.046396683051 0.344262295081967 8.1 8 1 abnormal lens morphology 0.00926274633419379 0.0940240907058504 1.04483954512979 0.34375 8.1 8 1 neonatal lethality 0.145727194154593 0.553788367575443 1.04483954512979 0.34375 8.1 8 1 thick pulmonary interalveolar septum 0.134308545890437 0.532418339286791 1.0421256761814 0.342857142857143 8.1 8 1 decreased glycogen level 0.134308545890437 0.532418339286791 1.0421256761814 0.342857142857143 8.1 8 1 increased red blood cell distribution width 0.134308545890437 0.532418339286791 1.0421256761814 0.342857142857143 8.1 8 1 decreased hematocrit 0.00633865922603458 0.0699220169612462 1.04093603499855 0.342465753424658 8.1 8 1 abnormal frontal bone morphology 0.123981005944674 0.498510374696687 1.03984031285644 0.342105263157895 8.1 8 1 liver fibrosis 0.114605774005894 0.465439776064754 1.03788939294489 0.341463414634146 8.1 8 1 palatal shelves fail to meet at midline 0.114605774005894 0.465439776064754 1.03788939294489 0.341463414634146 8.1 8 1 renal interstitial fibrosis 0.1060683515776 0.452533928045801 1.03620450756674 0.340909090909091 8.1 8 1 hepatic necrosis 0.0982729405270742 0.440490599298943 1.03473471393898 0.340425531914894 8.1 8 1 increased respiratory quotient 0.0982729405270742 0.440490599298943 1.03473471393898 0.340425531914894 8.1 8 1 microphthalmia 0.00646454962439138 0.071152952171122 1.03304397094235 0.339869281045752 8.1 8 1 abnormal spleen morphology 0.0041629017436174 0.0490768629727407 1.03064632246868 0.339080459770115 8.1 8 1 increased circulating triglyceride level 0.00902139593355452 0.0923486517889583 1.02715260612133 0.337931034482759 8.1 8 1 cachexia 0.025882689660545 0.189241969090996 1.0229198343928 0.336538461538462 8.1 8 1 decreased T cell number 0.00754029401206575 0.0793085892389579 1.01947077017746 0.335403726708075 8.1 8 1 decreased litter size 0.000628903708206125 0.0108429164025384 1.01678335546762 0.334519572953737 8.1 8 1 skin lesions 0.0789853112874462 0.368968942399103 1.01317774073192 0.333333333333333 8.1 8 1 impaired hematopoiesis 0.106434453724446 0.452533928045801 1.01317774073192 0.333333333333333 8.1 8 1 enlarged spleen 0.00063422887902285 0.0108429164025384 1.01317774073192 0.333333333333333 8.1 8 1 increased food intake 0.0480357782563231 0.289655504945353 1.01317774073192 0.333333333333333 8.1 8 1 spleen hyperplasia 0.0592651298627751 0.312991717174029 1.01317774073192 0.333333333333333 8.1 8 1 abnormal limb morphology 0.0592651298627751 0.312991717174029 1.01317774073192 0.333333333333333 8.1 8 1 abnormal digit morphology 0.0636238770742105 0.323357954530108 1.01317774073192 0.333333333333333 8.1 8 1 hyperkeratosis 0.0683395413422057 0.337625837316259 1.01317774073192 0.333333333333333 8.1 8 1 abnormal mandible morphology 0.0986614864733437 0.440490599298943 1.01317774073192 0.333333333333333 8.1 8 1 abnormal small intestine morphology 0.0986614864733437 0.440490599298943 1.01317774073192 0.333333333333333 8.1 8 1 abnormal long bone epiphyseal plate proliferative zone 0.0986614864733437 0.440490599298943 1.01317774073192 0.333333333333333 8.1 8 1 oligodactyly 0.11493449547725 0.4656344584685 1.01317774073192 0.333333333333333 8.1 8 1 abnormal cardiovascular system morphology 0.11493449547725 0.4656344584685 1.01317774073192 0.333333333333333 8.1 8 1 abnormal ovarian follicle morphology 0.124251832085204 0.498510374696687 1.01317774073192 0.333333333333333 8.1 8 1 increased circulating corticosterone level 0.124251832085204 0.498510374696687 1.01317774073192 0.333333333333333 8.1 8 1 abnormal pancreas morphology 0.134493085248635 0.532595874537457 1.01317774073192 0.333333333333333 8.1 8 1 abnormal iris morphology 0.145785719504175 0.553788367575443 1.01317774073192 0.333333333333333 8.1 8 1 acanthosis 0.145785719504175 0.553788367575443 1.01317774073192 0.333333333333333 8.1 8 1 narrow eye opening 0.158284186719741 0.557431791649567 1.01317774073192 0.333333333333333 8.1 8 1 abnormal epidermis stratum basale morphology 0.172178649890185 0.573492995652538 1.01317774073192 0.333333333333333 8.1 8 1 dilated heart atrium 0.172178649890185 0.573492995652538 1.01317774073192 0.333333333333333 8.1 8 1 abnormal hair cycle 0.187707747759115 0.614757083473411 1.01317774073192 0.333333333333333 8.1 8 1 abnormal lactation 0.187707747759115 0.614757083473411 1.01317774073192 0.333333333333333 8.1 8 1 liver hemorrhage 0.187707747759115 0.614757083473411 1.01317774073192 0.333333333333333 8.1 8 1 hemolytic anemia 0.224994135882994 0.616704791023923 1.01317774073192 0.333333333333333 8.1 8 1 abnormal eye muscle morphology 0.205177945462924 0.616704791023923 1.01317774073192 0.333333333333333 8.1 8 1 dry skin 0.247710582626359 0.616704791023923 1.01317774073192 0.333333333333333 8.1 8 1 abnormal osteoblast morphology 0.224994135882994 0.616704791023923 1.01317774073192 0.333333333333333 8.1 8 1 hypopigmentation 0.224994135882994 0.616704791023923 1.01317774073192 0.333333333333333 8.1 8 1 increased circulating total protein level 0.224994135882994 0.616704791023923 1.01317774073192 0.333333333333333 8.1 8 1 abnormal tumor vascularization 0.247710582626359 0.616704791023923 1.01317774073192 0.333333333333333 8.1 8 1 decreased vocalization 0.247710582626359 0.616704791023923 1.01317774073192 0.333333333333333 8.1 8 1 abnormal mitral valve morphology 0.274121310389582 0.647556276917459 1.01317774073192 0.333333333333333 8.1 8 1 cortical renal glomerulopathies 0.274121310389582 0.647556276917459 1.01317774073192 0.333333333333333 8.1 8 1 abnormal phrenic nerve morphology 0.274121310389582 0.647556276917459 1.01317774073192 0.333333333333333 8.1 8 1 abnormal thyroid cartilage morphology 0.274121310389582 0.647556276917459 1.01317774073192 0.333333333333333 8.1 8 1 abnormal thymus cortex morphology 0.274121310389582 0.647556276917459 1.01317774073192 0.333333333333333 8.1 8 1 abnormal bile duct morphology 0.274121310389582 0.647556276917459 1.01317774073192 0.333333333333333 8.1 8 1 acidosis 0.274121310389582 0.647556276917459 1.01317774073192 0.333333333333333 8.1 8 1 abnormal metacarpal bone morphology 0.274121310389582 0.647556276917459 1.01317774073192 0.333333333333333 8.1 8 1 abnormal redox activity 0.274121310389582 0.647556276917459 1.01317774073192 0.333333333333333 8.1 8 1 decreased cellular sensitivity to gamma-irradiation 0.274121310389582 0.647556276917459 1.01317774073192 0.333333333333333 8.1 8 1 long tibia 0.274121310389582 0.647556276917459 1.01317774073192 0.333333333333333 8.1 8 1 abnormal neutrophil morphology 0.274121310389582 0.647556276917459 1.01317774073192 0.333333333333333 8.1 8 1 abnormal pregnancy 0.274121310389582 0.647556276917459 1.01317774073192 0.333333333333333 8.1 8 1 increased effector memory CD4-positive, alpha-beta T cell number 0.274121310389582 0.647556276917459 1.01317774073192 0.333333333333333 8.1 8 1 decreased fluid intake 0.274121310389582 0.647556276917459 1.01317774073192 0.333333333333333 8.1 8 1 absent incisors 0.305434105766611 0.703488276013374 1.01317774073192 0.333333333333333 8.1 8 1 macrocytosis 0.305434105766611 0.703488276013374 1.01317774073192 0.333333333333333 8.1 8 1 hyperpigmentation 0.305434105766611 0.703488276013374 1.01317774073192 0.333333333333333 8.1 8 1 no suckling reflex 0.305434105766611 0.703488276013374 1.01317774073192 0.333333333333333 8.1 8 1 abnormal cricoid cartilage morphology 0.305434105766611 0.703488276013374 1.01317774073192 0.333333333333333 8.1 8 1 abnormal pericyte morphology 0.305434105766611 0.703488276013374 1.01317774073192 0.333333333333333 8.1 8 1 greasy coat 0.305434105766611 0.703488276013374 1.01317774073192 0.333333333333333 8.1 8 1 bicuspid aortic valve 0.305434105766611 0.703488276013374 1.01317774073192 0.333333333333333 8.1 8 1 abnormal coronary vessel morphology 0.305434105766611 0.703488276013374 1.01317774073192 0.333333333333333 8.1 8 1 decreased trabecular bone mass 0.305434105766611 0.703488276013374 1.01317774073192 0.333333333333333 8.1 8 1 abnormal branching involved in lung morphogenesis 0.305434105766611 0.703488276013374 1.01317774073192 0.333333333333333 8.1 8 1 abnormal cardiovascular system physiology 0.018814591819839 0.146942848200469 1.00555986298206 0.330827067669173 8.1 8 1 small ovary 0.0480637317898711 0.289655504945353 1.0020439194052 0.32967032967033 8.1 8 1 increased double-negative T cell number 0.0981567467231426 0.440490599298943 0.996568269572381 0.327868852459016 8.1 8 1 decreased circulating calcium level 0.114111162746802 0.464188908148274 0.994756327264067 0.327272727272727 8.1 8 1 organ of Corti degeneration 0.133172977294349 0.529963868097697 0.992500643982289 0.326530612244898 8.1 8 1 abnormal long bone hypertrophic chondrocyte zone 0.133172977294349 0.529963868097697 0.992500643982289 0.326530612244898 8.1 8 1 absent kidney 0.133172977294349 0.529963868097697 0.992500643982289 0.326530612244898 8.1 8 1 abnormal male reproductive system morphology 0.156168351544878 0.557431791649567 0.989615467691643 0.325581395348837 8.1 8 1 abnormal female reproductive system morphology 0.169487660858018 0.565527238610758 0.987848297213622 0.325 8.1 8 1 polyuria 0.078090250534089 0.365130635720952 0.986861435777844 0.324675324675325 8.1 8 1 increased granulocyte number 0.0839051427721419 0.389028970448654 0.985794558549977 0.324324324324324 8.1 8 1 increased white adipose tissue amount 0.184265495179893 0.606698106234261 0.985794558549977 0.324324324324324 8.1 8 1 decreased pancreatic beta cell number 0.200738741633996 0.616704791023923 0.983378395416275 0.323529411764706 8.1 8 1 increased lung adenoma incidence 0.21920582520265 0.616704791023923 0.980494587805084 0.32258064516129 8.1 8 1 abnormal capillary morphology 0.21920582520265 0.616704791023923 0.980494587805084 0.32258064516129 8.1 8 1 decreased thymus weight 0.21920582520265 0.616704791023923 0.980494587805084 0.32258064516129 8.1 8 1 decreased neuronal precursor cell number 0.21920582520265 0.616704791023923 0.980494587805084 0.32258064516129 8.1 8 1 increased circulating luteinizing hormone level 0.240051285525345 0.616704791023923 0.976992821420066 0.321428571428571 8.1 8 1 abnormal respiration 0.240051285525345 0.616704791023923 0.976992821420066 0.321428571428571 8.1 8 1 decreased circulating progesterone level 0.240051285525345 0.616704791023923 0.976992821420066 0.321428571428571 8.1 8 1 corneal vascularization 0.240051285525345 0.616704791023923 0.976992821420066 0.321428571428571 8.1 8 1 abnormal vertebrae morphology 0.0502354368061063 0.294025056600446 0.975996906209648 0.321100917431193 8.1 8 1 abnormal skeleton development 0.082748883821135 0.384384404304525 0.975652639223331 0.320987654320988 8.1 8 1 increased monocyte cell number 0.0616302102100798 0.314472098251433 0.972650631102643 0.32 8.1 8 1 decreased circulating alkaline phosphatase level 0.152953942982391 0.553788367575443 0.972650631102643 0.32 8.1 8 1 abnormal circulating protein level 0.152953942982391 0.553788367575443 0.972650631102643 0.32 8.1 8 1 abnormal inner ear vestibule morphology 0.263784418141096 0.629413659593262 0.972650631102643 0.32 8.1 8 1 abnormal thyroid gland morphology 0.263784418141096 0.629413659593262 0.972650631102643 0.32 8.1 8 1 abnormal keratinocyte physiology 0.263784418141096 0.629413659593262 0.972650631102643 0.32 8.1 8 1 decreased placenta weight 0.263784418141096 0.629413659593262 0.972650631102643 0.32 8.1 8 1 abnormal neurocranium morphology 0.0955004429647853 0.43628531106502 0.972650631102643 0.32 8.1 8 1 abnormal heart left ventricle morphology 0.102682575075961 0.445375598084487 0.970962001534757 0.319444444444444 8.1 8 1 pulmonary hypoplasia 0.165604861921218 0.557431791649567 0.970063794317796 0.319148936170213 8.1 8 1 abnormal epidermal layer morphology 0.110474213487989 0.452533928045801 0.969126534613141 0.318840579710145 8.1 8 1 abnormal long bone epiphysis morphology 0.291103014431435 0.677062878352684 0.967124207062288 0.318181818181818 8.1 8 1 increased activated T cell number 0.291103014431435 0.677062878352684 0.967124207062288 0.318181818181818 8.1 8 1 abnormal oogenesis 0.291103014431435 0.677062878352684 0.967124207062288 0.318181818181818 8.1 8 1 testis hypoplasia 0.291103014431435 0.677062878352684 0.967124207062288 0.318181818181818 8.1 8 1 abnormal lysosome physiology 0.291103014431435 0.677062878352684 0.967124207062288 0.318181818181818 8.1 8 1 abnormal cochlear sensory epithelium morphology 0.291103014431435 0.677062878352684 0.967124207062288 0.318181818181818 8.1 8 1 abnormal female reproductive system physiology 0.291103014431435 0.677062878352684 0.967124207062288 0.318181818181818 8.1 8 1 abnormal circulating lipid level 0.291103014431435 0.677062878352684 0.967124207062288 0.318181818181818 8.1 8 1 abnormal blood-brain barrier function 0.291103014431435 0.677062878352684 0.967124207062288 0.318181818181818 8.1 8 1 sparse hair 0.0936691296336371 0.428312426403809 0.963754436305973 0.317073170731707 8.1 8 1 increased tumor growth/size 0.194968536896504 0.616704791023923 0.963754436305973 0.317073170731707 8.1 8 1 short humerus 0.194968536896504 0.616704791023923 0.963754436305973 0.317073170731707 8.1 8 1 hemopericardium 0.194968536896504 0.616704791023923 0.963754436305973 0.317073170731707 8.1 8 1 abnormal cholesterol homeostasis 0.194968536896504 0.616704791023923 0.963754436305973 0.317073170731707 8.1 8 1 increased bone trabecula number 0.194968536896504 0.616704791023923 0.963754436305973 0.317073170731707 8.1 8 1 alopecia 0.0797364641215522 0.372128432462216 0.959852596482872 0.315789473684211 8.1 8 1 abnormal craniofacial bone morphology 0.14912501674653 0.553788367575443 0.959852596482872 0.315789473684211 8.1 8 1 abnormal circulating amino acid level 0.14912501674653 0.553788367575443 0.959852596482872 0.315789473684211 8.1 8 1 increased bone marrow cell number 0.212089105596149 0.616704791023923 0.959852596482872 0.315789473684211 8.1 8 1 irregular coat pigmentation 0.323004884376199 0.725812691857086 0.959852596482872 0.315789473684211 8.1 8 1 flaky skin 0.323004884376199 0.725812691857086 0.959852596482872 0.315789473684211 8.1 8 1 abnormal nasal septum morphology 0.323004884376199 0.725812691857086 0.959852596482872 0.315789473684211 8.1 8 1 abnormal neural crest cell migration 0.323004884376199 0.725812691857086 0.959852596482872 0.315789473684211 8.1 8 1 increased left ventricle weight 0.323004884376199 0.725812691857086 0.959852596482872 0.315789473684211 8.1 8 1 increased liver cholesterol level 0.323004884376199 0.725812691857086 0.959852596482872 0.315789473684211 8.1 8 1 increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 0.323004884376199 0.725812691857086 0.959852596482872 0.315789473684211 8.1 8 1 abnormal dermal layer morphology 0.231185914683127 0.616704791023923 0.955281869832953 0.314285714285714 8.1 8 1 abnormal cervical vertebrae morphology 0.174219995214594 0.578601118953676 0.953579050100631 0.313725490196078 8.1 8 1 maternal effect 0.134567440059012 0.532595874537457 0.952689517404641 0.313432835820896 8.1 8 1 deafness 0.0835323632661171 0.387661853776989 0.95177302917241 0.313131313131313 8.1 8 1 abnormal tooth morphology 0.144961673163345 0.553788367575443 0.949854131936175 0.3125 8.1 8 1 increased dopamine level 0.252605202951767 0.616704791023923 0.949854131936175 0.3125 8.1 8 1 decreased mast cell number 0.360998028107506 0.77299631077782 0.949854131936175 0.3125 8.1 8 1 mixed cellular infiltration to dermis 0.360998028107506 0.77299631077782 0.949854131936175 0.3125 8.1 8 1 intraventricular hemorrhage 0.360998028107506 0.77299631077782 0.949854131936175 0.3125 8.1 8 1 abnormal meiosis 0.360998028107506 0.77299631077782 0.949854131936175 0.3125 8.1 8 1 abnormal epicardium morphology 0.360998028107506 0.77299631077782 0.949854131936175 0.3125 8.1 8 1 decreased circulating growth hormone level 0.360998028107506 0.77299631077782 0.949854131936175 0.3125 8.1 8 1 loose skin 0.360998028107506 0.77299631077782 0.949854131936175 0.3125 8.1 8 1 decreased creatinine clearance 0.360998028107506 0.77299631077782 0.949854131936175 0.3125 8.1 8 1 kidney degeneration 0.360998028107506 0.77299631077782 0.949854131936175 0.3125 8.1 8 1 increased heart left ventricle size 0.360998028107506 0.77299631077782 0.949854131936175 0.3125 8.1 8 1 embryonic lethality between somite formation and embryo turning, incomplete penetrance 0.360998028107506 0.77299631077782 0.949854131936175 0.3125 8.1 8 1 decreased adipocyte glucose uptake 0.360998028107506 0.77299631077782 0.949854131936175 0.3125 8.1 8 1 increased osteoclast cell number 0.156280589065723 0.557431791649567 0.946739856093762 0.311475409836066 8.1 8 1 improved glucose tolerance 0.0254225835890183 0.188916224265285 0.945977176295619 0.311224489795918 8.1 8 1 abnormal rib morphology 0.0557614215863104 0.309267639232881 0.945632558016459 0.311111111111111 8.1 8 1 thrombocytosis 0.168626847486768 0.563032594796424 0.943303413784891 0.310344827586207 8.1 8 1 abnormal middle ear morphology 0.276790723776496 0.652932124603163 0.943303413784891 0.310344827586207 8.1 8 1 abnormal circulating glucose level 0.276790723776496 0.652932124603163 0.943303413784891 0.310344827586207 8.1 8 1 aphagia 0.276790723776496 0.652932124603163 0.943303413784891 0.310344827586207 8.1 8 1 atelectasis 0.140633705831135 0.553788367575443 0.941827195609954 0.309859154929577 8.1 8 1 abnormal joint morphology 0.182118447141264 0.602820541934656 0.939492086860508 0.309090909090909 8.1 8 1 abnormal B cell differentiation 0.114739992471562 0.465604781848305 0.93524099144485 0.307692307692308 8.1 8 1 increased urine protein level 0.136247450512326 0.538816427900494 0.93524099144485 0.307692307692308 8.1 8 1 decreased monocyte cell number 0.162960821913266 0.557431791649567 0.93524099144485 0.307692307692308 8.1 8 1 small lens 0.241557277192582 0.616704791023923 0.93524099144485 0.307692307692308 8.1 8 1 increased vascular permeability 0.241557277192582 0.616704791023923 0.93524099144485 0.307692307692308 8.1 8 1 abnormal female meiosis 0.196891887126217 0.616704791023923 0.93524099144485 0.307692307692308 8.1 8 1 increased percent body fat/body weight 0.196891887126217 0.616704791023923 0.93524099144485 0.307692307692308 8.1 8 1 abnormal xiphoid process morphology 0.304325654613243 0.703488276013374 0.93524099144485 0.307692307692308 8.1 8 1 abnormal kidney cortex morphology 0.304325654613243 0.703488276013374 0.93524099144485 0.307692307692308 8.1 8 1 abnormal Schwann cell morphology 0.304325654613243 0.703488276013374 0.93524099144485 0.307692307692308 8.1 8 1 thick skin 0.304325654613243 0.703488276013374 0.93524099144485 0.307692307692308 8.1 8 1 abnormal ocular fundus morphology 0.304325654613243 0.703488276013374 0.93524099144485 0.307692307692308 8.1 8 1 decreased Peyer's patch number 0.304325654613243 0.703488276013374 0.93524099144485 0.307692307692308 8.1 8 1 decreased B cell number 0.0333619838084817 0.226433655453201 0.929565985428801 0.305825242718447 8.1 8 1 cataract 0.0857271914543674 0.397106869167111 0.92944404315077 0.305785123966942 8.1 8 1 abnormal lysosome morphology 0.263262674987016 0.629376169178475 0.928746262337594 0.305555555555556 8.1 8 1 increased inflammatory response 0.119104830084608 0.480183573477248 0.927857509933443 0.305263157894737 8.1 8 1 decreased birth weight 0.119104830084608 0.480183573477248 0.927857509933443 0.305263157894737 8.1 8 1 abnormal inner ear morphology 0.230948170503763 0.616704791023923 0.925075328494362 0.304347826086957 8.1 8 1 abnormal retinal cone cell morphology 0.336000172436761 0.74993309011794 0.925075328494362 0.304347826086957 8.1 8 1 bidirectional circling 0.336000172436761 0.74993309011794 0.925075328494362 0.304347826086957 8.1 8 1 hypotension 0.336000172436761 0.74993309011794 0.925075328494362 0.304347826086957 8.1 8 1 abnormal nasal cavity morphology 0.336000172436761 0.74993309011794 0.925075328494362 0.304347826086957 8.1 8 1 abnormal Wolffian duct morphology 0.336000172436761 0.74993309011794 0.925075328494362 0.304347826086957 8.1 8 1 abnormal basicranium morphology 0.336000172436761 0.74993309011794 0.925075328494362 0.304347826086957 8.1 8 1 abnormal hepatocyte physiology 0.336000172436761 0.74993309011794 0.925075328494362 0.304347826086957 8.1 8 1 decreased effector memory CD8-positive, alpha-beta T cell number 0.336000172436761 0.74993309011794 0.925075328494362 0.304347826086957 8.1 8 1 kinked tail 0.115279666725876 0.46622269675346 0.923779704784986 0.303921568627451 8.1 8 1 abnormal skin morphology 0.182101169996357 0.602820541934656 0.921070673392655 0.303030303030303 8.1 8 1 abnormal tooth development 0.28757326950028 0.671679350123894 0.921070673392655 0.303030303030303 8.1 8 1 abnormal axial skeleton morphology 0.162985265075432 0.557431791649567 0.919858738296086 0.302631578947368 8.1 8 1 abnormal coat/ hair morphology 0.220870186423905 0.616704791023923 0.917594935002494 0.30188679245283 8.1 8 1 abnormal hair follicle morphology 0.196103857027496 0.616704791023923 0.916684622566976 0.301587301587302 8.1 8 1 abnormal pancreatic beta cell morphology 0.27244425562168 0.647556276917459 0.911859966658728 0.3 8.1 8 1 abnormal basioccipital bone morphology 0.372926231500076 0.793205644169678 0.911859966658728 0.3 8.1 8 1 abnormal hyoid bone morphology 0.372926231500076 0.793205644169678 0.911859966658728 0.3 8.1 8 1 abnormal physiological neovascularization 0.372926231500076 0.793205644169678 0.911859966658728 0.3 8.1 8 1 dilated vasculature 0.372926231500076 0.793205644169678 0.911859966658728 0.3 8.1 8 1 abnormal incus morphology 0.372926231500076 0.793205644169678 0.911859966658728 0.3 8.1 8 1 nuclear cataracts 0.372926231500076 0.793205644169678 0.911859966658728 0.3 8.1 8 1 abnormal long bone epiphyseal plate morphology 0.21133620933042 0.616704791023923 0.911859966658728 0.3 8.1 8 1 abnormal eye physiology 0.21133620933042 0.616704791023923 0.911859966658728 0.3 8.1 8 1 delayed eyelid opening 0.31496914206966 0.710884010115589 0.911859966658728 0.3 8.1 8 1 disorganized myocardium 0.31496914206966 0.710884010115589 0.911859966658728 0.3 8.1 8 1 cleft secondary palate 0.155660497977663 0.556729674650518 0.90539287469661 0.297872340425532 8.1 8 1 abnormal T-helper 1 physiology 0.258669574144843 0.618692851620477 0.90539287469661 0.297872340425532 8.1 8 1 increased insulin secretion 0.296684558751569 0.689078281880978 0.903645012004145 0.297297297297297 8.1 8 1 decreased width of hypertrophic chondrocyte zone 0.296684558751569 0.689078281880978 0.903645012004145 0.297297297297297 8.1 8 1 increased leukocyte cell number 0.102946080825178 0.446129575004582 0.901378817616674 0.296551724137931 8.1 8 1 abnormal osteoblast physiology 0.246037417009559 0.616704791023923 0.900602436206151 0.296296296296296 8.1 8 1 abnormal heart valve morphology 0.346072058466009 0.764863834237402 0.900602436206151 0.296296296296296 8.1 8 1 wrinkled skin 0.346072058466009 0.764863834237402 0.900602436206151 0.296296296296296 8.1 8 1 corneal opacity 0.208115410135796 0.616704791023923 0.899016868536774 0.295774647887324 8.1 8 1 small kidney 0.178153266838292 0.590481347448702 0.898043906557839 0.295454545454545 8.1 8 1 increased T cell number 0.178153266838292 0.590481347448702 0.898043906557839 0.295454545454545 8.1 8 1 abnormal amino acid level 0.280451443082763 0.65596893715879 0.898043906557839 0.295454545454545 8.1 8 1 distended abdomen 0.265829800143902 0.633382785304556 0.893980359469342 0.294117647058824 8.1 8 1 abnormal gluconeogenesis 0.265829800143902 0.633382785304556 0.893980359469342 0.294117647058824 8.1 8 1 abnormal trophoblast layer morphology 0.265829800143902 0.633382785304556 0.893980359469342 0.294117647058824 8.1 8 1 abnormal oocyte morphology 0.323754322777899 0.726184741127162 0.893980359469341 0.294117647058824 8.1 8 1 lung hemorrhage 0.323754322777899 0.726184741127162 0.893980359469341 0.294117647058824 8.1 8 1 overexpanded pulmonary alveoli 0.323754322777899 0.726184741127162 0.893980359469341 0.294117647058824 8.1 8 1 abnormal bone remodeling 0.323754322777899 0.726184741127162 0.893980359469341 0.294117647058824 8.1 8 1 abnormal interatrial septum morphology 0.416745481158033 0.814146339236925 0.893980359469341 0.294117647058824 8.1 8 1 enlarged sebaceous gland 0.416745481158033 0.814146339236925 0.893980359469341 0.294117647058824 8.1 8 1 abnormal heart rate 0.416745481158033 0.814146339236925 0.893980359469341 0.294117647058824 8.1 8 1 abnormal cranial suture morphology 0.416745481158033 0.814146339236925 0.893980359469341 0.294117647058824 8.1 8 1 increased regulatory T cell number 0.416745481158033 0.814146339236925 0.893980359469341 0.294117647058824 8.1 8 1 abnormal melanosome morphology 0.416745481158033 0.814146339236925 0.893980359469341 0.294117647058824 8.1 8 1 decreased growth hormone level 0.416745481158033 0.814146339236925 0.893980359469341 0.294117647058824 8.1 8 1 abnormal survival 0.416745481158033 0.814146339236925 0.893980359469341 0.294117647058824 8.1 8 1 glomerulosclerosis 0.252519776551791 0.616704791023923 0.89089766857462 0.293103448275862 8.1 8 1 Leydig cell hyperplasia 0.304503173714856 0.703488276013374 0.889619479667052 0.292682926829268 8.1 8 1 abnormal intestinal epithelium morphology 0.287506579576287 0.671679350123894 0.88653052314043 0.291666666666667 8.1 8 1 abnormal kidney physiology 0.287506579576287 0.671679350123894 0.88653052314043 0.291666666666667 8.1 8 1 abnormal malleus morphology 0.381708540429489 0.809808097499663 0.88653052314043 0.291666666666667 8.1 8 1 small lymph nodes 0.381708540429489 0.809808097499663 0.88653052314043 0.291666666666667 8.1 8 1 abnormal cardiac muscle contractility 0.381708540429489 0.809808097499663 0.88653052314043 0.291666666666667 8.1 8 1 abnormal inner cell mass apoptosis 0.381708540429489 0.809808097499663 0.88653052314043 0.291666666666667 8.1 8 1 abnormal lung saccule morphology 0.381708540429489 0.809808097499663 0.88653052314043 0.291666666666667 8.1 8 1 decreased B cell proliferation 0.218556031569258 0.616704791023923 0.884927393803829 0.291139240506329 8.1 8 1 osteopetrosis 0.354145044424346 0.77299631077782 0.882445129024576 0.290322580645161 8.1 8 1 abnormal cranial ganglia morphology 0.354145044424346 0.77299631077782 0.882445129024576 0.290322580645161 8.1 8 1 absent mature ovarian follicles 0.354145044424346 0.77299631077782 0.882445129024576 0.290322580645161 8.1 8 1 abnormal blood homeostasis 0.175443346929721 0.582275284173023 0.879864880109299 0.289473684210526 8.1 8 1 abnormal reproductive system physiology 0.331149373000074 0.741768631551268 0.879864880109299 0.289473684210526 8.1 8 1 impaired branching involved in ureteric bud morphogenesis 0.331149373000074 0.741768631551268 0.879864880109299 0.289473684210526 8.1 8 1 decreased osteoclast cell number 0.311298196466876 0.710884010115589 0.878087375300998 0.288888888888889 8.1 8 1 abnormal skin condition 0.29377760271864 0.682964286694033 0.876788429479546 0.288461538461538 8.1 8 1 abnormal colon morphology 0.278073001764868 0.655129328624471 0.875797708090304 0.288135593220339 8.1 8 1 syndactyly 0.278073001764868 0.655129328624471 0.875797708090304 0.288135593220339 8.1 8 1 abnormal jaw morphology 0.388480367642274 0.814146339236925 0.868438063484503 0.285714285714286 8.1 8 1 increased triglyceride level 0.388480367642274 0.814146339236925 0.868438063484503 0.285714285714286 8.1 8 1 thick epidermis 0.268808307825884 0.639866665757786 0.868438063484503 0.285714285714286 8.1 8 1 dehydration 0.268808307825884 0.639866665757786 0.868438063484503 0.285714285714286 8.1 8 1 skin edema 0.337473154353613 0.752882934040011 0.868438063484503 0.285714285714286 8.1 8 1 abnormal artery morphology 0.360781686015807 0.77299631077782 0.868438063484503 0.285714285714286 8.1 8 1 abnormal intestinal goblet cell morphology 0.360781686015807 0.77299631077782 0.868438063484503 0.285714285714286 8.1 8 1 impaired adaptive thermogenesis 0.360781686015807 0.77299631077782 0.868438063484503 0.285714285714286 8.1 8 1 abnormal hematopoietic system physiology 0.423012491049562 0.814146339236925 0.868438063484503 0.285714285714286 8.1 8 1 increased vasoconstriction 0.423012491049562 0.814146339236925 0.868438063484503 0.285714285714286 8.1 8 1 hypoalgesia 0.423012491049562 0.814146339236925 0.868438063484503 0.285714285714286 8.1 8 1 vascular ring 0.423012491049562 0.814146339236925 0.868438063484503 0.285714285714286 8.1 8 1 abnormal lipid homeostasis 0.188566695352849 0.614757083473411 0.865097917086486 0.284615384615385 8.1 8 1 increased liver weight 0.247396056728457 0.616704791023923 0.863503756305614 0.284090909090909 8.1 8 1 abnormal response to injury 0.366346267781588 0.781549177621527 0.857304242157779 0.282051282051282 8.1 8 1 abnormal vertebral body morphology 0.393878025870138 0.814146339236925 0.854868718742558 0.28125 8.1 8 1 increased circulating follicle stimulating hormone level 0.393878025870138 0.814146339236925 0.854868718742558 0.28125 8.1 8 1 increased fatty acid level 0.393878025870138 0.814146339236925 0.854868718742558 0.28125 8.1 8 1 abnormal liver physiology 0.258425298365098 0.618405896761118 0.851069302214813 0.28 8.1 8 1 spontaneous skin ulceration 0.42756792131942 0.814146339236925 0.851069302214813 0.28 8.1 8 1 increased pre-B cell number 0.42756792131942 0.814146339236925 0.851069302214813 0.28 8.1 8 1 diaphragmatic hernia 0.42756792131942 0.814146339236925 0.851069302214813 0.28 8.1 8 1 abnormal cochlear outer hair cell morphology 0.42756792131942 0.814146339236925 0.851069302214813 0.28 8.1 8 1 decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 0.42756792131942 0.814146339236925 0.851069302214813 0.28 8.1 8 1 kidney failure 0.371086311122895 0.791322073654695 0.84824182944998 0.27906976744186 8.1 8 1 abnormal epidermis stratum granulosum morphology 0.398288997949957 0.814146339236925 0.844314783943267 0.277777777777778 8.1 8 1 abnormal retinal blood vessel morphology 0.398288997949957 0.814146339236925 0.844314783943267 0.277777777777778 8.1 8 1 abnormal stomach glandular epithelium morphology 0.471600931453591 0.848540554785395 0.844314783943267 0.277777777777778 8.1 8 1 abnormal radius morphology 0.471600931453591 0.848540554785395 0.844314783943267 0.277777777777778 8.1 8 1 thick dermal layer 0.471600931453591 0.848540554785395 0.844314783943267 0.277777777777778 8.1 8 1 blepharoptosis 0.471600931453591 0.848540554785395 0.844314783943267 0.277777777777778 8.1 8 1 eye inflammation 0.471600931453591 0.848540554785395 0.844314783943267 0.277777777777778 8.1 8 1 abnormal thymus medulla morphology 0.471600931453591 0.848540554785395 0.844314783943267 0.277777777777778 8.1 8 1 abnormal Peyer's patch follicle morphology 0.471600931453591 0.848540554785395 0.844314783943267 0.277777777777778 8.1 8 1 increased circulating renin level 0.471600931453591 0.848540554785395 0.844314783943267 0.277777777777778 8.1 8 1 abnormal anterior eye segment morphology 0.471600931453591 0.848540554785395 0.844314783943267 0.277777777777778 8.1 8 1 abnormal sperm axoneme morphology 0.471600931453591 0.848540554785395 0.844314783943267 0.277777777777778 8.1 8 1 small thoracic cage 0.471600931453591 0.848540554785395 0.844314783943267 0.277777777777778 8.1 8 1 abnormal macrophage chemotaxis 0.471600931453591 0.848540554785395 0.844314783943267 0.277777777777778 8.1 8 1 abnormal metanephric mesenchyme morphology 0.471600931453591 0.848540554785395 0.844314783943267 0.277777777777778 8.1 8 1 abnormal chondrocyte morphology 0.351987395601845 0.77299631077782 0.844314783943267 0.277777777777778 8.1 8 1 abnormal tibia morphology 0.375176578676871 0.797651059366425 0.840721955075423 0.276595744680851 8.1 8 1 dermatitis 0.355763098559198 0.77299631077782 0.838491923364348 0.275862068965517 8.1 8 1 decreased granulocyte number 0.431028803400665 0.814146339236925 0.838491923364348 0.275862068965517 8.1 8 1 increased susceptibility to weight loss 0.401964272393967 0.814146339236925 0.835871636103834 0.275 8.1 8 1 short femur 0.329641378883215 0.739056268564216 0.828963606053389 0.272727272727273 8.1 8 1 cochlear hair cell degeneration 0.405074386637944 0.814146339236925 0.828963606053389 0.272727272727273 8.1 8 1 abnormal chorion morphology 0.472478544781359 0.848596927582543 0.828963606053389 0.272727272727273 8.1 8 1 abnormal mesenteric lymph node morphology 0.472478544781359 0.848596927582543 0.828963606053389 0.272727272727273 8.1 8 1 decreased susceptibility to viral infection induced morbidity/mortality 0.472478544781359 0.848596927582543 0.828963606053389 0.272727272727273 8.1 8 1 impaired humoral immune response 0.472478544781359 0.848596927582543 0.828963606053389 0.272727272727273 8.1 8 1 abnormal tail morphology 0.362203248763995 0.773042111797888 0.828963606053389 0.272727272727273 8.1 8 1 abnormal T cell subpopulation ratio 0.433742309508834 0.814146339236925 0.828963606053389 0.272727272727273 8.1 8 1 diarrhea 0.433742309508834 0.814146339236925 0.828963606053389 0.272727272727273 8.1 8 1 decreased sensitivity to xenobiotic induced morbidity/mortality 0.433742309508834 0.814146339236925 0.828963606053389 0.272727272727273 8.1 8 1 abnormal osteoclast morphology 0.407739721199945 0.814146339236925 0.823206914344685 0.270833333333333 8.1 8 1 abnormal leukocyte migration 0.410047942435359 0.814146339236925 0.818335867514243 0.269230769230769 8.1 8 1 abnormal stomach morphology 0.472972966948012 0.848596927582543 0.818335867514243 0.269230769230769 8.1 8 1 short mandible 0.412064572240939 0.814146339236925 0.814160684516722 0.267857142857143 8.1 8 1 altered response to myocardial infarction 0.439174819427423 0.823866789838397 0.810542192585536 0.266666666666667 8.1 8 1 arrested T cell differentiation 0.473232316611939 0.848596927582543 0.810542192585536 0.266666666666667 8.1 8 1 abnormal renal glomerulus morphology 0.361894426113783 0.77299631077782 0.808683150859423 0.26605504587156 8.1 8 1 abnormal osteoclast physiology 0.415412205696043 0.814146339236925 0.807376012145749 0.265625 8.1 8 1 abnormal epidermis stratum corneum morphology 0.440410523185841 0.825251357005484 0.80640677323561 0.26530612244898 8.1 8 1 abnormal respiratory system physiology 0.440410523185841 0.825251357005484 0.80640677323561 0.26530612244898 8.1 8 1 increased fluid intake 0.440410523185841 0.825251357005484 0.80640677323561 0.26530612244898 8.1 8 1 abnormal brown adipose tissue morphology 0.473337984731971 0.848596927582543 0.804582323522407 0.264705882352941 8.1 8 1 abnormal placenta development 0.441455002696761 0.826897077717014 0.802895568127182 0.264150943396226 8.1 8 1 abnormal nail morphology 0.524670948266946 0.933227732437632 0.799877163735727 0.263157894736842 8.1 8 1 short vibrissae 0.524670948266946 0.933227732437632 0.799877163735727 0.263157894736842 8.1 8 1 increased circulating VLDL cholesterol level 0.524670948266946 0.933227732437632 0.799877163735727 0.263157894736842 8.1 8 1 decreased fertilization frequency 0.524670948266946 0.933227732437632 0.799877163735727 0.263157894736842 8.1 8 1 shortened RR interval 0.524670948266946 0.933227732437632 0.799877163735727 0.263157894736842 8.1 8 1 thin interventricular septum 0.524670948266946 0.933227732437632 0.799877163735727 0.263157894736842 8.1 8 1 abnormal cartilage morphology 0.473264376203716 0.848596927582543 0.796068224860795 0.261904761904762 8.1 8 1 abnormal forelimb morphology 0.473136083814349 0.848596927582543 0.792921710138025 0.260869565217391 8.1 8 1 delayed wound healing 0.473136083814349 0.848596927582543 0.792921710138025 0.260869565217391 8.1 8 1 abnormal blood vessel physiology 0.520647382079453 0.928061886723496 0.792921710138025 0.260869565217391 8.1 8 1 blistering 0.520647382079453 0.928061886723496 0.792921710138025 0.260869565217391 8.1 8 1 abnormal postnatal growth 0.520647382079453 0.928061886723496 0.792921710138025 0.260869565217391 8.1 8 1 abnormal B cell morphology 0.520647382079453 0.928061886723496 0.792921710138025 0.260869565217391 8.1 8 1 abnormal skeleton morphology 0.405056407578479 0.814146339236925 0.792921710138025 0.260869565217391 8.1 8 1 abnormal coat appearance 0.444321923654755 0.831953921784872 0.792921710138025 0.260869565217391 8.1 8 1 abnormal trabecular bone morphology 0.405818266889224 0.814146339236925 0.791811175529988 0.260504201680672 8.1 8 1 cryptorchism 0.517388284916713 0.92357614548283 0.788027131680382 0.259259259259259 8.1 8 1 abnormal body temperature homeostasis 0.514653976503276 0.919024958041565 0.784395670244067 0.258064516129032 8.1 8 1 abnormal CD8-positive, alpha beta T cell morphology 0.514653976503276 0.919024958041565 0.784395670244067 0.258064516129032 8.1 8 1 abnormal intestine physiology 0.514653976503276 0.919024958041565 0.784395670244067 0.258064516129032 8.1 8 1 decreased circulating thyroxine level 0.512299780441413 0.915807189254771 0.781594257136053 0.257142857142857 8.1 8 1 abnormal lens fiber morphology 0.510232305727518 0.912637260310783 0.779367492870708 0.256410256410256 8.1 8 1 decreased trabecular bone volume 0.510232305727518 0.912637260310783 0.779367492870708 0.256410256410256 8.1 8 1 delayed endochondral bone ossification 0.508388086075248 0.910122608213155 0.777555010329148 0.255813953488372 8.1 8 1 increased circulating glucose level 0.447331459211427 0.836959010747216 0.776051035454237 0.25531914893617 8.1 8 1 increased neutrophil cell number 0.447311578444534 0.836959010747216 0.775605029112022 0.255172413793103 8.1 8 1 increased hemoglobin content 0.502504225502925 0.899913074829752 0.772762683609092 0.254237288135593 8.1 8 1 decreased compact bone thickness 0.500157020076551 0.896032111948448 0.771224847422805 0.253731343283582 8.1 8 1 abnormal femur morphology 0.500157020076551 0.896032111948448 0.771224847422805 0.253731343283582 8.1 8 1 abnormal stria vascularis morphology 0.560357590674859 0.935044567286257 0.75988330554894 0.25 8.1 8 1 kidney cortex cysts 0.554912626714322 0.935044567286257 0.75988330554894 0.25 8.1 8 1 curly vibrissae 0.566960329296107 0.935044567286257 0.75988330554894 0.25 8.1 8 1 impaired wound healing 0.550303374605232 0.935044567286257 0.75988330554894 0.25 8.1 8 1 abnormal hair growth 0.536919730768604 0.935044567286257 0.75988330554894 0.25 8.1 8 1 perinatal lethality 0.546321650172036 0.935044567286257 0.75988330554894 0.25 8.1 8 1 abnormal limb bone morphology 0.550303374605232 0.935044567286257 0.75988330554894 0.25 8.1 8 1 abnormal lumbar vertebrae morphology 0.554912626714322 0.935044567286257 0.75988330554894 0.25 8.1 8 1 decreased ovulation rate 0.566960329296107 0.935044567286257 0.75988330554894 0.25 8.1 8 1 abnormal hair shaft morphology 0.539716359415332 0.935044567286257 0.75988330554894 0.25 8.1 8 1 short radius 0.550303374605232 0.935044567286257 0.75988330554894 0.25 8.1 8 1 decreased fatty acid level 0.566960329296107 0.935044567286257 0.75988330554894 0.25 8.1 8 1 decreased body temperature 0.536919730768604 0.935044567286257 0.75988330554894 0.25 8.1 8 1 abnormal pericardium morphology 0.57525252052257 0.935255323398623 0.75988330554894 0.25 8.1 8 1 waved hair 0.57525252052257 0.935255323398623 0.75988330554894 0.25 8.1 8 1 abnormal lens epithelium morphology 0.57525252052257 0.935255323398623 0.75988330554894 0.25 8.1 8 1 abnormal male reproductive system physiology 0.57525252052257 0.935255323398623 0.75988330554894 0.25 8.1 8 1 abnormal heart right ventricle morphology 0.57525252052257 0.935255323398623 0.75988330554894 0.25 8.1 8 1 abnormal heart electrocardiography waveform feature 0.57525252052257 0.935255323398623 0.75988330554894 0.25 8.1 8 1 liver inflammation 0.510343087072281 0.912637260310783 0.75988330554894 0.25 8.1 8 1 abnormal kidney development 0.532059077547084 0.935044567286257 0.75988330554894 0.25 8.1 8 1 abnormal incisor morphology 0.532059077547084 0.935044567286257 0.75988330554894 0.25 8.1 8 1 decreased IgM level 0.540257608632864 0.935044567286257 0.752049457038126 0.247422680412371 8.1 8 1 decreased urine osmolality 0.571923657651923 0.935044567286257 0.744375482986717 0.244897959183673 8.1 8 1 increased sensitivity to induced morbidity/mortality 0.565863335228818 0.935044567286257 0.743364103254398 0.244565217391304 8.1 8 1 abnormal autopod morphology 0.576360186801296 0.936750058587535 0.742997009870075 0.244444444444444 8.1 8 1 abnormal response/metabolism to endogenous compounds 0.572904757384932 0.935044567286257 0.74134956638921 0.24390243902439 8.1 8 1 arrested B cell differentiation 0.581360889396464 0.943644510521177 0.74134956638921 0.24390243902439 8.1 8 1 short ulna 0.581360889396464 0.943644510521177 0.74134956638921 0.24390243902439 8.1 8 1 abnormal angiogenesis 0.578787759643814 0.940388342334414 0.739345918912482 0.243243243243243 8.1 8 1 decreased T cell proliferation 0.579958924520783 0.94198356170124 0.739345918912482 0.243243243243243 8.1 8 1 lung inflammation 0.585657011826929 0.946853576523007 0.737533796562207 0.242647058823529 8.1 8 1 abnormal aorta morphology 0.593687128220079 0.95833662001781 0.736856538714124 0.242424242424242 8.1 8 1 abnormal middle ear ossicle morphology 0.593687128220079 0.95833662001781 0.736856538714124 0.242424242424242 8.1 8 1 abnormal microglial cell morphology 0.601507659353012 0.96414640450834 0.733680432943804 0.241379310344828 8.1 8 1 decreased retinal photoreceptor cell number 0.601507659353012 0.96414640450834 0.733680432943804 0.241379310344828 8.1 8 1 abnormal digestive system physiology 0.603172956088802 0.96612538845518 0.729487973326983 0.24 8.1 8 1 ruffled hair 0.61097898444664 0.977055753012547 0.729487973326983 0.24 8.1 8 1 abnormal feces composition 0.61097898444664 0.977055753012547 0.729487973326983 0.24 8.1 8 1 abnormal energy expenditure 0.61097898444664 0.977055753012547 0.729487973326983 0.24 8.1 8 1 abnormal stomach mucosa morphology 0.61097898444664 0.977055753012547 0.729487973326983 0.24 8.1 8 1 abnormal immune system morphology 0.608802047740051 0.974827868524865 0.726844900959856 0.239130434782609 8.1 8 1 abnormal scapula morphology 0.622827529732885 0.984664225794026 0.723698386237086 0.238095238095238 8.1 8 1 abnormal erythrocyte physiology 0.622827529732885 0.984664225794026 0.723698386237086 0.238095238095238 8.1 8 1 increased acute inflammation 0.622827529732885 0.984664225794026 0.723698386237086 0.238095238095238 8.1 8 1 abnormal clavicle morphology 0.622827529732885 0.984664225794026 0.723698386237086 0.238095238095238 8.1 8 1 abnormal bile salt homeostasis 0.622827529732885 0.984664225794026 0.723698386237086 0.238095238095238 8.1 8 1 increased bone ossification 0.622827529732885 0.984664225794026 0.723698386237086 0.238095238095238 8.1 8 1 abnormal spleen red pulp morphology 0.630717633908727 0.990473557037852 0.715184287575473 0.235294117647059 8.1 8 1 increased systemic arterial blood pressure 0.639993112369613 1 0.71138011583305 0.234042553191489 8.1 8 1 abnormal cytokine secretion 0.683934574727956 1 0.710540233760048 0.233766233766234 8.1 8 1 gastrointestinal hemorrhage 0.640547981056817 1 0.709224418512344 0.233333333333333 8.1 8 1 salivary gland inflammation 0.640547981056817 1 0.709224418512344 0.233333333333333 8.1 8 1 emphysema 0.640547981056817 1 0.709224418512344 0.233333333333333 8.1 8 1 abnormal pain threshold 0.640547981056817 1 0.709224418512344 0.233333333333333 8.1 8 1 abnormal fat pad morphology 0.640547981056817 1 0.709224418512344 0.233333333333333 8.1 8 1 increased lymphocyte cell number 0.663432806668196 1 0.704819297900466 0.231884057971014 8.1 8 1 no spontaneous movement 0.652380789696229 1 0.701430743583637 0.230769230769231 8.1 8 1 impaired macrophage chemotaxis 0.656005036267804 1 0.701430743583637 0.230769230769231 8.1 8 1 decreased B-1 B cell number 0.656005036267804 1 0.701430743583637 0.230769230769231 8.1 8 1 decreased bone resorption 0.652380789696229 1 0.701430743583637 0.230769230769231 8.1 8 1 short limbs 0.688145089586535 1 0.69874326947029 0.229885057471264 8.1 8 1 abnormal T cell activation 0.681735081199114 1 0.698271145639567 0.22972972972973 8.1 8 1 abnormal long bone morphology 0.675480281874235 1 0.697597788700666 0.229508196721311 8.1 8 1 abnormal urine homeostasis 0.699079146987739 1 0.696559696753195 0.229166666666667 8.1 8 1 abnormal humoral immune response 0.709260097698537 1 0.694750450787603 0.228571428571429 8.1 8 1 decreased bone mineralization 0.665804405306449 1 0.694750450787603 0.228571428571429 8.1 8 1 decreased susceptibility to induced arthritis 0.682322825080698 1 0.69322687523763 0.228070175438596 8.1 8 1 abnormal T cell differentiation 0.713808240714673 1 0.692170931787153 0.227722772277228 8.1 8 1 osteoporosis 0.678274093535897 1 0.690803005044491 0.227272727272727 8.1 8 1 abnormal facial nerve morphology 0.66704781942451 1 0.690803005044491 0.227272727272727 8.1 8 1 intestinal inflammation 0.66704781942451 1 0.690803005044491 0.227272727272727 8.1 8 1 abnormal gametogenesis 0.678274093535897 1 0.690803005044491 0.227272727272727 8.1 8 1 abnormal tracheal cartilage morphology 0.66704781942451 1 0.690803005044491 0.227272727272727 8.1 8 1 abnormal occipital bone morphology 0.66704781942451 1 0.690803005044491 0.227272727272727 8.1 8 1 increased eosinophil cell number 0.700588985949317 1 0.686346211463559 0.225806451612903 8.1 8 1 decreased double-negative T cell number 0.677267065718267 1 0.686346211463559 0.225806451612903 8.1 8 1 abnormal CD4-positive, alpha-beta T cell physiology 0.710635790285056 1 0.684965233170876 0.225352112676056 8.1 8 1 decreased IgG level 0.740607035282851 1 0.684579554548595 0.225225225225225 8.1 8 1 abnormal systemic arterial blood pressure 0.698804699792512 1 0.675451827154614 0.222222222222222 8.1 8 1 abnormal type II pneumocyte morphology 0.690950076776091 1 0.675451827154613 0.222222222222222 8.1 8 1 increased B cell number 0.768819689503043 1 0.675451827154613 0.222222222222222 8.1 8 1 decreased platelet aggregation 0.716038103938279 1 0.675451827154613 0.222222222222222 8.1 8 1 abnormal bone trabecula morphology 0.690950076776091 1 0.675451827154613 0.222222222222222 8.1 8 1 decreased bone ossification 0.690950076776091 1 0.675451827154613 0.222222222222222 8.1 8 1 abnormal hindlimb morphology 0.724924586138842 1 0.668697308883067 0.22 8.1 8 1 fragile skeleton 0.707714607575915 1 0.660768091781687 0.217391304347826 8.1 8 1 abnormal carpal bone morphology 0.707714607575915 1 0.660768091781687 0.217391304347826 8.1 8 1 abnormal cochlear ganglion morphology 0.707714607575915 1 0.660768091781687 0.217391304347826 8.1 8 1 abnormal sacral vertebrae morphology 0.707714607575915 1 0.660768091781687 0.217391304347826 8.1 8 1 abnormal circulating cholesterol level 0.726566209349153 1 0.651328547613377 0.214285714285714 8.1 8 1 abnormal spleen germinal center morphology 0.726566209349153 1 0.651328547613377 0.214285714285714 8.1 8 1 enlarged pericardium 0.743252241829181 1 0.644749471374858 0.212121212121212 8.1 8 1 decreased systemic arterial blood pressure 0.743252241829181 1 0.644749471374858 0.212121212121212 8.1 8 1 abnormal intestinal mucosa morphology 0.77181767225284 1 0.636181372087485 0.209302325581395 8.1 8 1 abnormal adrenal gland morphology 0.744755207123233 1 0.63323608795745 0.208333333333333 8.1 8 1 decreased body height 0.744755207123233 1 0.63323608795745 0.208333333333333 8.1 8 1 abnormal vasodilation 0.744755207123233 1 0.63323608795745 0.208333333333333 8.1 8 1 abnormal inflammatory response 0.817197866054576 1 0.63323608795745 0.208333333333333 8.1 8 1 decreased bone strength 0.759190178913364 1 0.628868942523261 0.206896551724138 8.1 8 1 decreased regulatory T cell number 0.77242788091967 1 0.625786251628539 0.205882352941176 8.1 8 1 abnormal dendritic cell physiology 0.869686089517937 1 0.624950755965484 0.205607476635514 8.1 8 1 increased autoantibody level 0.784612802197661 1 0.623493994296566 0.205128205128205 8.1 8 1 hypertension 0.795871735351481 1 0.621722704540042 0.204545454545455 8.1 8 1 decreased macrophage cell number 0.795871735351481 1 0.621722704540042 0.204545454545455 8.1 8 1 abnormal response to infection 0.855974738017992 1 0.615601665254838 0.20253164556962 8.1 8 1 impaired ovarian folliculogenesis 0.808803852753819 1 0.607906644439152 0.2 8.1 8 1 abnormal T-helper 2 physiology 0.83483110021257 1 0.607906644439152 0.2 8.1 8 1 decreased bone volume 0.799083749822974 1 0.607906644439152 0.2 8.1 8 1 abnormal spleen marginal zone morphology 0.788850728377501 1 0.607906644439152 0.2 8.1 8 1 abnormal lymphocyte physiology 0.83823258897819 1 0.594691282603518 0.195652173913043 8.1 8 1 abnormal immune system physiology 0.93646274903787 1 0.58829675268305 0.193548387096774 8.1 8 1 autoimmune response 0.815630807415716 1 0.58829675268305 0.193548387096774 8.1 8 1 abnormal leukocyte cell number 0.808156042100988 1 0.584525619653031 0.192307692307692 8.1 8 1 decreased IgA level 0.862383646390611 1 0.584525619653031 0.192307692307692 8.1 8 1 abnormal tectorial membrane morphology 0.808156042100988 1 0.584525619653031 0.192307692307692 8.1 8 1 decreased susceptibility to injury 0.891230992441526 1 0.581087233655072 0.191176470588235 8.1 8 1 abnormal cytotoxic T cell physiology 0.850882311537088 1 0.578958708989669 0.19047619047619 8.1 8 1 abnormal humerus morphology 0.845143224254459 1 0.57504682582082 0.189189189189189 8.1 8 1 abnormal crypts of Lieberkuhn morphology 0.83965492251795 1 0.569912479161705 0.1875 8.1 8 1 abnormal lymph node morphology 0.873382480109487 1 0.569912479161705 0.1875 8.1 8 1 abnormal phalanx morphology 0.873382480109487 1 0.569912479161705 0.1875 8.1 8 1 abnormal compact bone morphology 0.864768402181323 1 0.559914014615009 0.184210526315789 8.1 8 1 decreased sensitivity to induced morbidity/mortality 0.885194783251394 1 0.552642404035593 0.181818181818182 8.1 8 1 absent vibrissae 0.861077740448787 1 0.552642404035593 0.181818181818182 8.1 8 1 decreased inflammatory response 0.948792474268861 1 0.542773789677814 0.178571428571429 8.1 8 1 increased width of hypertrophic chondrocyte zone 0.880074138919313 1 0.536388215681605 0.176470588235294 8.1 8 1 decreased osteoblast cell number 0.880074138919313 1 0.536388215681605 0.176470588235294 8.1 8 1 abnormal thrombosis 0.914195410282168 1 0.536388215681605 0.176470588235294 8.1 8 1 decreased cytotoxic T cell cytolysis 0.880074138919313 1 0.536388215681605 0.176470588235294 8.1 8 1 abnormal parietal bone morphology 0.878973846742139 1 0.524057452102717 0.172413793103448 8.1 8 1 increased susceptibility to induced arthritis 0.878973846742139 1 0.524057452102717 0.172413793103448 8.1 8 1 decreased bone trabecula number 0.924158917606381 1 0.517367356969491 0.170212765957447 8.1 8 1 increased susceptibility to bacterial infection induced morbidity/mortality 0.962973746490762 1 0.50658887036596 0.166666666666667 8.1 8 1 abnormal long bone metaphysis morphology 0.924389935933156 1 0.492897279274988 0.162162162162162 8.1 8 1 abnormal hair follicle development 0.924389935933156 1 0.492897279274988 0.162162162162162 8.1 8 1 skin inflammation 0.924389935933156 1 0.492897279274988 0.162162162162162 8.1 8 1 abnormal cartilage development 0.951994449970934 1 0.472816279008229 0.155555555555556 8.1 8 1 abnormal skeleton physiology 0.93778534685467 1 0.460535336696327 0.151515151515152 8.1 8 1 abnormal NK cell physiology 0.98003499649171 1 0.448455721307571 0.147540983606557 8.1 8 1 increased susceptibility to viral infection induced morbidity/mortality 0.947735555119387 1 0.446990179734671 0.147058823529412 8.1 8 1 abnormal vibrissa morphology 0.966954789345261 1 0.434219031742252 0.142857142857143 8.1 8 1 impaired macrophage phagocytosis 0.972212864802613 1 0.42412091472499 0.13953488372093 8.1 8 1 impaired natural killer cell mediated cytotoxicity 0.993842062198918 1 0.373276009743339 0.12280701754386 8.1 8 1 increased B cell proliferation 0.995741727463403 1 0.360622585684243 0.11864406779661 8.1 8 1 increased susceptibility to parasitic infection 0.999889199236338 1 0.303953322219576 0.1 8.1 8 1 aorta hypoplasia 0.000106654912712719 0.00193652624359772 5.22687224669604 1 9.1 9 1 abnormal lambdoidal suture morphology 1.71149706623228e-05 0.000413334849733282 5.22687224669603 1 9.1 9 1 abnormal aorta tunica adventitia morphology 1.71149706623228e-05 0.000413334849733282 5.22687224669603 1 9.1 9 1 abnormal pulmonary circulation 1.88845577933148e-05 0.000451685937604525 4.57351321585903 0.875 9.1 9 1 thick pulmonary valve 0.000103328645627882 0.00188300370695499 4.48017621145374 0.857142857142857 9.1 9 1 impaired branching involved in bronchus morphogenesis 0.000103328645627882 0.00188300370695499 4.48017621145374 0.857142857142857 9.1 9 1 embryo tumor 0.000103328645627882 0.00188300370695499 4.48017621145374 0.857142857142857 9.1 9 1 thick pulmonary valve cusps 0.000554354622964697 0.00708975385411149 4.3557268722467 0.833333333333333 9.1 9 1 abnormal aorta smooth muscle morphology 2.84612370619512e-06 9.63228941382364e-05 4.27653183820585 0.818181818181818 9.1 9 1 abnormal aorta wall morphology 8.20259170050968e-08 4.63726064886769e-06 4.18149779735683 0.8 9.1 9 1 thick aortic valve cusps 1.45787166359855e-05 0.000368168097786943 4.18149779735683 0.8 9.1 9 1 thick aortic valve 1.45787166359855e-05 0.000368168097786943 4.18149779735683 0.8 9.1 9 1 decreased circulating lactate level 1.45787166359855e-05 0.000368168097786943 4.18149779735683 0.8 9.1 9 1 premature bone ossification 7.30825441119506e-05 0.00139139977207718 4.06534508076358 0.777777777777778 9.1 9 1 abnormal thymus physiology 7.30825441119506e-05 0.00139139977207718 4.06534508076358 0.777777777777778 9.1 9 1 abnormal pulmonary alveolar parenchyma morphology 7.30825441119506e-05 0.00139139977207718 4.06534508076358 0.777777777777778 9.1 9 1 abnormal aorta tunica media morphology 2.0215790979022e-06 7.39511471475253e-05 4.02067095899695 0.769230769230769 9.1 9 1 abnormal somite size 0.000356660909131583 0.00502303698328491 3.92015418502203 0.75 9.1 9 1 abnormal aorta elastic tissue morphology 9.74690276750549e-06 0.000267905200377568 3.92015418502203 0.75 9.1 9 1 delayed intramembranous bone ossification 1.31489377478776e-06 5.15086340910953e-05 3.83303964757709 0.733333333333333 9.1 9 1 abnormal sphenoid bone morphology 4.58656311154261e-05 0.000935170142619857 3.80136163396075 0.727272727272727 9.1 9 1 decreased atrioventricular cushion size 4.58656311154261e-05 0.000935170142619857 3.80136163396075 0.727272727272727 9.1 9 1 abnormal bronchiole morphology 4.58656311154261e-05 0.000935170142619857 3.80136163396075 0.727272727272727 9.1 9 1 abnormal palatal shelf elevation 4.58656311154261e-05 0.000935170142619857 3.80136163396075 0.727272727272727 9.1 9 1 abnormal sagittal suture morphology 6.04855014495654e-06 0.000175973900416133 3.73348017621145 0.714285714285714 9.1 9 1 abnormal gastrulation movements 0.00168191956630674 0.0167686369586694 3.73348017621145 0.714285714285714 9.1 9 1 aorta coarctation 0.00168191956630674 0.0167686369586694 3.73348017621145 0.714285714285714 9.1 9 1 abnormal nephron morphology 0.00168191956630674 0.0167686369586694 3.73348017621145 0.714285714285714 9.1 9 1 abnormal spinal cord central canal morphology 0.00168191956630674 0.0167686369586694 3.73348017621145 0.714285714285714 9.1 9 1 abnormal sperm annulus morphology 0.00168191956630674 0.0167686369586694 3.73348017621145 0.714285714285714 9.1 9 1 abnormal conotruncal ridge morphology 0.00168191956630674 0.0167686369586694 3.73348017621145 0.714285714285714 9.1 9 1 decreased collagen level 0.00168191956630674 0.0167686369586694 3.73348017621145 0.714285714285714 9.1 9 1 abnormal otic capsule morphology 0.000209591474889203 0.00328932992925485 3.65881057268722 0.7 9.1 9 1 primary sex reversal 0.000209591474889203 0.00328932992925485 3.65881057268722 0.7 9.1 9 1 increased circulating fructosamine level 0.000209591474889203 0.00328932992925485 3.65881057268722 0.7 9.1 9 1 absent hypoglossal nerve 2.71288810241128e-05 0.000613482650431641 3.61860386309725 0.692307692307692 9.1 9 1 abnormal epicardium morphology 3.59230891598725e-06 0.000116050239331406 3.59347466960352 0.6875 9.1 9 1 abnormal pulmonary valve cusp morphology 0.000118103087811268 0.00209224560634656 3.48458149779736 0.666666666666667 9.1 9 1 decreased level of surface class I molecules 0.000923817639170846 0.0105655005859194 3.48458149779736 0.666666666666667 9.1 9 1 abnormal incisor color 0.000923817639170846 0.0105655005859194 3.48458149779736 0.666666666666667 9.1 9 1 decreased bone trabecular spacing 0.000923817639170846 0.0105655005859194 3.48458149779736 0.666666666666667 9.1 9 1 increased myeloid cell number 0.000923817639170846 0.0105655005859194 3.48458149779736 0.666666666666667 9.1 9 1 adipose tissue inflammation 0.000923817639170846 0.0105655005859194 3.48458149779736 0.666666666666667 9.1 9 1 multiple persisting craniopharyngeal ducts 6.50734766065942e-05 0.00127960690165141 3.36013215859031 0.642857142857143 9.1 9 1 abnormal ureter development 0.000496111701493312 0.00649922827294669 3.32619142971566 0.636363636363636 9.1 9 1 abnormal pulmonary alveolar sac morphology 0.000496111701493312 0.00649922827294669 3.32619142971566 0.636363636363636 9.1 9 1 increased subcutaneous adipose tissue amount 0.000496111701493312 0.00649922827294669 3.32619142971566 0.636363636363636 9.1 9 1 thin dermal layer 4.80304268997261e-06 0.000151235046725404 3.3011824715975 0.631578947368421 9.1 9 1 abnormal exoccipital bone morphology 0.00389068399493201 0.0308218994821445 3.26679515418502 0.625 9.1 9 1 hypospadia 0.00389068399493201 0.0308218994821445 3.26679515418502 0.625 9.1 9 1 absent tympanic ring 0.00389068399493201 0.0308218994821445 3.26679515418502 0.625 9.1 9 1 elevated level of mitotic sister chromatid exchange 0.00389068399493201 0.0308218994821445 3.26679515418502 0.625 9.1 9 1 tau protein deposits 0.00389068399493201 0.0308218994821445 3.26679515418502 0.625 9.1 9 1 long femur 0.00389068399493201 0.0308218994821445 3.26679515418502 0.625 9.1 9 1 bowed fibula 0.00389068399493201 0.0308218994821445 3.26679515418502 0.625 9.1 9 1 abnormal vertebral body development 0.00389068399493201 0.0308218994821445 3.26679515418502 0.625 9.1 9 1 ocular hypertension 0.00389068399493201 0.0308218994821445 3.26679515418502 0.625 9.1 9 1 skin fibrosis 0.00389068399493201 0.0308218994821445 3.26679515418502 0.625 9.1 9 1 pleural effusion 0.00389068399493201 0.0308218994821445 3.26679515418502 0.625 9.1 9 1 abnormal bronchiole epithelium morphology 0.00389068399493201 0.0308218994821445 3.26679515418502 0.625 9.1 9 1 abnormal pulmonary acinus morphology 0.00389068399493201 0.0308218994821445 3.26679515418502 0.625 9.1 9 1 decreased surfactant secretion 0.00389068399493201 0.0308218994821445 3.26679515418502 0.625 9.1 9 1 increased aorta wall thickness 0.00389068399493201 0.0308218994821445 3.26679515418502 0.625 9.1 9 1 abnormal heart echocardiography feature 0.00389068399493201 0.0308218994821445 3.26679515418502 0.625 9.1 9 1 absent hypoglossal canal 0.00389068399493201 0.0308218994821445 3.26679515418502 0.625 9.1 9 1 absent myocardial trabeculae 0.000263661818670716 0.00396289289391786 3.21653676719756 0.615384615384615 9.1 9 1 abnormal hypoglossal nerve topology 1.90898747519397e-05 0.000454412090387082 3.19419970631424 0.611111111111111 9.1 9 1 abnormal pericyte morphology 0.000139409897188544 0.00239987625783047 3.13612334801762 0.6 9.1 9 1 heterochrony 0.000139409897188544 0.00239987625783047 3.13612334801762 0.6 9.1 9 1 abnormal respiratory mechanics 0.00199515688559331 0.0190882798188976 3.13612334801762 0.6 9.1 9 1 impaired basement membrane formation 0.00199515688559331 0.0190882798188976 3.13612334801762 0.6 9.1 9 1 increased left ventricle diastolic pressure 0.00199515688559331 0.0190882798188976 3.13612334801762 0.6 9.1 9 1 abnormal respiratory conducting tube morphology 0.00199515688559331 0.0190882798188976 3.13612334801762 0.6 9.1 9 1 osteosclerosis 0.00199515688559331 0.0190882798188976 3.13612334801762 0.6 9.1 9 1 abnormal retinal blood vessel pattern 0.00199515688559331 0.0190882798188976 3.13612334801762 0.6 9.1 9 1 abnormal heart and great artery attachment 0.00199515688559331 0.0190882798188976 3.13612334801762 0.6 9.1 9 1 bradykinesia 3.23071499457306e-08 2.03453254405076e-06 3.10345539647577 0.59375 9.1 9 1 abnormal tracheal cartilage morphology 5.47843870166901e-06 0.000162233527028591 3.08860632759311 0.590909090909091 9.1 9 1 abnormal basement membrane morphology 5.47843870166901e-06 0.000162233527028591 3.08860632759311 0.590909090909091 9.1 9 1 pulmonary vascular congestion 5.47843870166901e-06 0.000162233527028591 3.08860632759311 0.590909090909091 9.1 9 1 abnormal bone marrow cavity morphology 7.35267858592057e-05 0.00139139977207718 3.07463073335061 0.588235294117647 9.1 9 1 interstitial pneumonia 0.00102532376064818 0.0112604541042488 3.04900881057269 0.583333333333333 9.1 9 1 abnormal rostral-caudal body axis extension 0.00102532376064818 0.0112604541042488 3.04900881057269 0.583333333333333 9.1 9 1 pale placenta 0.00102532376064818 0.0112604541042488 3.04900881057269 0.583333333333333 9.1 9 1 hematuria 0.00102532376064818 0.0112604541042488 3.04900881057269 0.583333333333333 9.1 9 1 abnormal palatine bone morphology 0.00102532376064818 0.0112604541042488 3.04900881057269 0.583333333333333 9.1 9 1 decreased red blood cell distribution width 0.00102532376064818 0.0112604541042488 3.04900881057269 0.583333333333333 9.1 9 1 decreased mammary gland epithelial cell proliferation 0.00102532376064818 0.0112604541042488 3.04900881057269 0.583333333333333 9.1 9 1 persistent right dorsal aorta 0.00102532376064818 0.0112604541042488 3.04900881057269 0.583333333333333 9.1 9 1 decreased liver regeneration 3.87342688371445e-05 0.000820012712616145 3.0260839322977 0.578947368421053 9.1 9 1 decreased susceptibility to weight gain 3.87342688371445e-05 0.000820012712616145 3.0260839322977 0.578947368421053 9.1 9 1 abnormal artery morphology 3.46032873325622e-08 2.15189193099371e-06 2.98678414096916 0.571428571428571 9.1 9 1 absent corpus callosum 8.28493589380841e-07 3.49301322641499e-05 2.98678414096916 0.571428571428571 9.1 9 1 abnormal clavicle morphology 2.03971140230245e-05 0.00048321734411689 2.98678414096916 0.571428571428571 9.1 9 1 abnormal blood flow velocity 0.000528446274756212 0.00681093320443564 2.98678414096916 0.571428571428571 9.1 9 1 irregularly shaped pupil 0.000528446274756212 0.00681093320443564 2.98678414096916 0.571428571428571 9.1 9 1 skeletal muscle necrosis 0.000528446274756212 0.00681093320443564 2.98678414096916 0.571428571428571 9.1 9 1 sternebra fusion 0.000528446274756212 0.00681093320443564 2.98678414096916 0.571428571428571 9.1 9 1 dilated heart 1.07411200155489e-05 0.000287296086437397 2.95431909595863 0.565217391304348 9.1 9 1 abnormal pulmonary elastic fiber morphology 0.000273151754215637 0.00402050289119169 2.94011563876652 0.5625 9.1 9 1 dilated respiratory conducting tubes 0.000273151754215637 0.00402050289119169 2.94011563876652 0.5625 9.1 9 1 abnormal atrioventricular cushion morphology 2.98130013628424e-06 9.89903589323001e-05 2.90381791483113 0.555555555555556 9.1 9 1 abnormal mitral valve morphology 0.000141572924743288 0.00242870793309606 2.90381791483113 0.555555555555556 9.1 9 1 abnormal cholinergic neuron morphology 0.00759926693963345 0.0510896662495627 2.90381791483113 0.555555555555556 9.1 9 1 biliary cyst 0.00759926693963345 0.0510896662495627 2.90381791483113 0.555555555555556 9.1 9 1 pancreas cysts 0.00759926693963345 0.0510896662495627 2.90381791483113 0.555555555555556 9.1 9 1 abnormal intervertebral disk development 0.00759926693963345 0.0510896662495627 2.90381791483113 0.555555555555556 9.1 9 1 positive geotaxis 0.00759926693963345 0.0510896662495627 2.90381791483113 0.555555555555556 9.1 9 1 abnormal ventricle myocardium morphology 0.00759926693963345 0.0510896662495627 2.90381791483113 0.555555555555556 9.1 9 1 iris coloboma 0.00759926693963345 0.0510896662495627 2.90381791483113 0.555555555555556 9.1 9 1 abnormal ductus venosus valve topology 0.00759926693963345 0.0510896662495627 2.90381791483113 0.555555555555556 9.1 9 1 abnormal infrahyoid muscle connection 0.00759926693963345 0.0510896662495627 2.90381791483113 0.555555555555556 9.1 9 1 pulmonary hypoplasia 8.02454968584252e-10 7.67733359366664e-08 2.89146124285313 0.553191489361702 9.1 9 1 abnormal pericardium morphology 7.35554050364419e-05 0.00139139977207718 2.87477973568282 0.55 9.1 9 1 abnormal vascular branching morphogenesis 3.82995244086509e-05 0.000819623794642339 2.85102122547056 0.545454545454545 9.1 9 1 premature suture closure 0.00379401110651332 0.0308218994821445 2.85102122547056 0.545454545454545 9.1 9 1 delayed hepatic development 0.00379401110651332 0.0308218994821445 2.85102122547056 0.545454545454545 9.1 9 1 abnormal glossopharyngeal ganglion morphology 0.00379401110651332 0.0308218994821445 2.85102122547056 0.545454545454545 9.1 9 1 abnormal larynx morphology 0.00379401110651332 0.0308218994821445 2.85102122547056 0.545454545454545 9.1 9 1 patent ductus arteriosus 0.00379401110651332 0.0308218994821445 2.85102122547056 0.545454545454545 9.1 9 1 abnormal radial glial cell morphology 0.00379401110651332 0.0308218994821445 2.85102122547056 0.545454545454545 9.1 9 1 abnormal coronal suture morphology 0.00379401110651332 0.0308218994821445 2.85102122547056 0.545454545454545 9.1 9 1 abnormal dorsal-ventral polarity of the somites 0.00379401110651332 0.0308218994821445 2.85102122547056 0.545454545454545 9.1 9 1 abnormal palate development 0.00379401110651332 0.0308218994821445 2.85102122547056 0.545454545454545 9.1 9 1 aorta dilation 0.00379401110651332 0.0308218994821445 2.85102122547056 0.545454545454545 9.1 9 1 thin hypoglossal nerve 0.00379401110651332 0.0308218994821445 2.85102122547056 0.545454545454545 9.1 9 1 abnormal ureter morphology 1.04419065568037e-05 0.000283871503388516 2.81446967129787 0.538461538461538 9.1 9 1 absent trabeculae carneae 0.00191392935962188 0.0186336566812502 2.81446967129787 0.538461538461538 9.1 9 1 dystrophic cardiac calcinosis 0.00191392935962188 0.0186336566812502 2.81446967129787 0.538461538461538 9.1 9 1 small superior cervical ganglion 5.46530769040358e-06 0.000162233527028591 2.80011013215859 0.535714285714286 9.1 9 1 subcutaneous edema 5.46530769040358e-06 0.000162233527028591 2.80011013215859 0.535714285714286 9.1 9 1 abnormal energy homeostasis 0.000973059277690691 0.0110777343398425 2.78766519823789 0.533333333333333 9.1 9 1 liver vascular congestion 0.000973059277690691 0.0110777343398425 2.78766519823789 0.533333333333333 9.1 9 1 abnormal adipose tissue morphology 0.000497729843616621 0.00649922827294669 2.76716766001555 0.529411764705882 9.1 9 1 abnormal cranial suture morphology 0.000497729843616621 0.00649922827294669 2.76716766001555 0.529411764705882 9.1 9 1 abnormal embryonic-extraembryonic boundary morphology 0.000497729843616621 0.00649922827294669 2.76716766001555 0.529411764705882 9.1 9 1 increased liver cholesterol level 0.000255838097972337 0.00392837820189004 2.75098539299791 0.526315789473684 9.1 9 1 overriding aortic valve 8.93009918176825e-09 6.25735822947846e-07 2.72232929515418 0.520833333333333 9.1 9 1 abnormal interventricular septum morphology 4.71933843134155e-09 3.55738010544306e-07 2.71797356828194 0.52 9.1 9 1 liver hypoplasia 2.49527491180681e-09 2.00225688487724e-07 2.71395289732294 0.519230769230769 9.1 9 1 abnormal parietal bone morphology 9.63702748111036e-06 0.000266356731769578 2.70355461036002 0.517241379310345 9.1 9 1 inner cell mass degeneration 5.03567990405006e-06 0.000156578172016557 2.69774051442376 0.516129032258065 9.1 9 1 abnormal dermal layer morphology 1.38130604775982e-06 5.36874811531647e-05 2.68810572687225 0.514285714285714 9.1 9 1 malocclusion 7.24868524683124e-07 3.13584426982482e-05 2.68406953208715 0.513513513513513 9.1 9 1 delayed endochondral bone ossification 1.05416531752917e-07 5.74406186398039e-06 2.67421370761193 0.511627906976744 9.1 9 1 trabecula carnea hypoplasia 5.55343308735743e-08 3.2890868582861e-06 2.67151248164464 0.511111111111111 9.1 9 1 abnormal cell adhesion 7.29378120678242e-09 5.25892195706413e-07 2.61343612334802 0.5 9.1 9 1 abnormal lactation 1.64095685084197e-05 0.000405056426001416 2.61343612334802 0.5 9.1 9 1 rib bifurcation 3.14875038673996e-05 0.000690089567137943 2.61343612334802 0.5 9.1 9 1 increased bone resorption 3.14875038673996e-05 0.000690089567137943 2.61343612334802 0.5 9.1 9 1 abnormal renal tubule epithelium morphology 3.14875038673996e-05 0.000690089567137943 2.61343612334802 0.5 9.1 9 1 abnormal basisphenoid bone morphology 0.00022575952589375 0.0035098551291294 2.61343612334802 0.5 9.1 9 1 abnormal long bone epiphysis morphology 0.00022575952589375 0.0035098551291294 2.61343612334802 0.5 9.1 9 1 abnormal lens epithelium morphology 0.000438120790908231 0.00600454802966516 2.61343612334802 0.5 9.1 9 1 abnormal heart right ventricle morphology 0.000438120790908231 0.00600454802966516 2.61343612334802 0.5 9.1 9 1 abnormal tympanic ring morphology 0.00167296680116574 0.0167686369586694 2.61343612334802 0.5 9.1 9 1 vasculature congestion 0.00167296680116574 0.0167686369586694 2.61343612334802 0.5 9.1 9 1 increased cochlear outer hair cell number 0.00167296680116574 0.0167686369586694 2.61343612334802 0.5 9.1 9 1 abnormal level of surface class II molecules 0.00167296680116574 0.0167686369586694 2.61343612334802 0.5 9.1 9 1 loose skin 0.00167296680116574 0.0167686369586694 2.61343612334802 0.5 9.1 9 1 abnormal thoracic cage shape 0.00167296680116574 0.0167686369586694 2.61343612334802 0.5 9.1 9 1 abnormal interparietal bone morphology 0.00329941244448754 0.0281553634842633 2.61343612334802 0.5 9.1 9 1 absent atrioventricular cushions 0.00329941244448754 0.0281553634842633 2.61343612334802 0.5 9.1 9 1 amyloid beta deposits 0.00329941244448754 0.0281553634842633 2.61343612334802 0.5 9.1 9 1 vascular smooth muscle hypoplasia 0.00329941244448754 0.0281553634842633 2.61343612334802 0.5 9.1 9 1 split sternum 0.00329941244448754 0.0281553634842633 2.61343612334802 0.5 9.1 9 1 pulmonary alveolar hemorrhage 0.00329941244448754 0.0281553634842633 2.61343612334802 0.5 9.1 9 1 increased cranium width 0.0132033769936736 0.078385203512561 2.61343612334802 0.5 9.1 9 1 jaundice 0.0132033769936736 0.078385203512561 2.61343612334802 0.5 9.1 9 1 fused cornea and lens 0.0132033769936736 0.078385203512561 2.61343612334802 0.5 9.1 9 1 aneurysm 0.0132033769936736 0.078385203512561 2.61343612334802 0.5 9.1 9 1 bifid ureter 0.0132033769936736 0.078385203512561 2.61343612334802 0.5 9.1 9 1 increased heart rate variability 0.0132033769936736 0.078385203512561 2.61343612334802 0.5 9.1 9 1 tachypnea 0.0132033769936736 0.078385203512561 2.61343612334802 0.5 9.1 9 1 absent axillary lymph nodes 0.0132033769936736 0.078385203512561 2.61343612334802 0.5 9.1 9 1 common ventricle 0.0132033769936736 0.078385203512561 2.61343612334802 0.5 9.1 9 1 aorta stenosis 0.0132033769936736 0.078385203512561 2.61343612334802 0.5 9.1 9 1 abnormal inferior vena cava valve morphology 0.0132033769936736 0.078385203512561 2.61343612334802 0.5 9.1 9 1 fusion of atlas and odontoid process 0.0132033769936736 0.078385203512561 2.61343612334802 0.5 9.1 9 1 abnormal adaptive thermogenesis 0.0132033769936736 0.078385203512561 2.61343612334802 0.5 9.1 9 1 small heart 4.96257782262747e-08 2.97455718886406e-06 2.61343612334802 0.5 9.1 9 1 heart right ventricle hypertrophy 2.3473193698904e-06 8.16637333231101e-05 2.61343612334802 0.5 9.1 9 1 renal hypoplasia 2.3473193698904e-06 8.16637333231101e-05 2.61343612334802 0.5 9.1 9 1 abnormal truncus arteriosus septation 0.000116745692990722 0.00208175563666252 2.61343612334802 0.5 9.1 9 1 abnormal heart shape 0.000853886762489955 0.00997203437414913 2.61343612334802 0.5 9.1 9 1 abnormal radius morphology 0.000853886762489955 0.00997203437414913 2.61343612334802 0.5 9.1 9 1 abnormal thymus cortex morphology 0.000853886762489955 0.00997203437414913 2.61343612334802 0.5 9.1 9 1 amyloidosis 0.00656269845237846 0.0463112408518906 2.61343612334802 0.5 9.1 9 1 mesocardia 0.00656269845237846 0.0463112408518906 2.61343612334802 0.5 9.1 9 1 abnormal mating frequency 0.00656269845237846 0.0463112408518906 2.61343612334802 0.5 9.1 9 1 abnormal embryonic growth/weight/body size 0.00656269845237846 0.0463112408518906 2.61343612334802 0.5 9.1 9 1 abnormal aorta elastic fiber morphology 0.00656269845237846 0.0463112408518906 2.61343612334802 0.5 9.1 9 1 decreased left ventricle systolic pressure 0.00656269845237846 0.0463112408518906 2.61343612334802 0.5 9.1 9 1 bowed ulna 0.00656269845237846 0.0463112408518906 2.61343612334802 0.5 9.1 9 1 abnormal behavioral response to addictive substance 0.00656269845237846 0.0463112408518906 2.61343612334802 0.5 9.1 9 1 decreased prostaglandin level 0.00656269845237846 0.0463112408518906 2.61343612334802 0.5 9.1 9 1 increased skeletal muscle glycogen level 0.00656269845237846 0.0463112408518906 2.61343612334802 0.5 9.1 9 1 abnormal vitelline vein connection 0.00656269845237846 0.0463112408518906 2.61343612334802 0.5 9.1 9 1 delayed bone ossification 2.10081003903656e-11 2.61288248605172e-09 2.57859030837004 0.493333333333333 9.1 9 1 perimembraneous ventricular septal defect 1.41037238265297e-10 1.46179220910386e-08 2.57556023750239 0.492753623188406 9.1 9 1 abnormal trophoblast layer morphology 4.34984967531863e-08 2.63908562618417e-06 2.56219227779217 0.490196078431373 9.1 9 1 increased vascular permeability 2.03895258716019e-06 7.40422563585545e-05 2.54642494069807 0.487179487179487 9.1 9 1 decreased width of hypertrophic chondrocyte zone 3.88437806534992e-06 0.0001243148033243 2.54280271460888 0.486486486486487 9.1 9 1 abnormal aorta morphology 1.41518274167589e-05 0.000362914130919461 2.53424108930717 0.484848484848485 9.1 9 1 pale yolk sac 8.43748073948002e-12 1.19932761939752e-09 2.51897457672098 0.481927710843373 9.1 9 1 abnormal fetal cardiomyocyte proliferation 9.96240031856752e-05 0.00184248853475366 2.51664219285365 0.481481481481481 9.1 9 1 abnormal keratinocyte physiology 0.000191744096832433 0.00308714201210795 2.5088986784141 0.48 9.1 9 1 fragile skeleton 0.000370039456195323 0.0051423080853959 2.49980846581115 0.478260869565217 9.1 9 1 abnormal pulmonary artery morphology 0.000370039456195323 0.0051423080853959 2.49980846581115 0.478260869565217 9.1 9 1 abnormal chondrocyte physiology 0.000370039456195323 0.0051423080853959 2.49980846581115 0.478260869565217 9.1 9 1 left pulmonary isomerism 0.000716385577960077 0.00869272743988142 2.48898678414097 0.476190476190476 9.1 9 1 abnormal compact bone morphology 6.27228926135077e-06 0.000180373636272949 2.47588685369812 0.473684210526316 9.1 9 1 short radius 1.19381580868361e-05 0.000315916683414946 2.46824522760646 0.472222222222222 9.1 9 1 enlarged liver sinusoidal spaces 2.27478157419813e-05 0.000528833566898863 2.45970458668049 0.470588235294118 9.1 9 1 abnormal interatrial septum morphology 0.00271762187454275 0.0243606645510814 2.45970458668049 0.470588235294118 9.1 9 1 increased regulatory T cell number 0.00271762187454275 0.0243606645510814 2.45970458668049 0.470588235294118 9.1 9 1 abnormal ectoplacental cone morphology 0.00271762187454275 0.0243606645510814 2.45970458668049 0.470588235294118 9.1 9 1 abnormal tendon morphology 0.00271762187454275 0.0243606645510814 2.45970458668049 0.470588235294118 9.1 9 1 increased trabecular bone mass 0.00271762187454275 0.0243606645510814 2.45970458668049 0.470588235294118 9.1 9 1 abnormal vertebral body morphology 4.34000218176533e-05 0.000903410495995085 2.45009636563877 0.46875 9.1 9 1 double outlet right ventricle 1.00841815131753e-13 2.18125230556727e-11 2.44246366668039 0.467289719626168 9.1 9 1 emphysema 8.29190309825131e-05 0.00155668746844529 2.43920704845815 0.466666666666667 9.1 9 1 abnormal cellular respiration 8.29190309825131e-05 0.00155668746844529 2.43920704845815 0.466666666666667 9.1 9 1 decreased chondrocyte number 0.00533497146543478 0.0390890766429131 2.43920704845815 0.466666666666667 9.1 9 1 abnormal cricoid cartilage morphology 0.00533497146543478 0.0390890766429131 2.43920704845815 0.466666666666667 9.1 9 1 bicuspid aortic valve 0.00533497146543478 0.0390890766429131 2.43920704845815 0.466666666666667 9.1 9 1 increased triglyceride level 0.000158675635928181 0.00262262886625483 2.42676211453744 0.464285714285714 9.1 9 1 increased bone trabecula number 5.22243793831409e-06 0.000160380424340201 2.42220908993231 0.463414634146341 9.1 9 1 failure of heart looping 9.90086355351408e-06 0.000270641737245783 2.41240257539817 0.461538461538462 9.1 9 1 abnormal xiphoid process morphology 0.000304193661745148 0.00441213838828604 2.41240257539817 0.461538461538462 9.1 9 1 pulmonary edema 0.000304193661745148 0.00441213838828604 2.41240257539817 0.461538461538462 9.1 9 1 absent teeth 0.0105473576747412 0.0655913805397971 2.41240257539817 0.461538461538462 9.1 9 1 absent common myeloid progenitor cells 0.0105473576747412 0.0655913805397971 2.41240257539817 0.461538461538462 9.1 9 1 abnormal renal/urinary system morphology 0.0105473576747412 0.0655913805397971 2.41240257539817 0.461538461538462 9.1 9 1 excessive scratching 0.0105473576747412 0.0655913805397971 2.41240257539817 0.461538461538462 9.1 9 1 abnormal coping response 0.0105473576747412 0.0655913805397971 2.41240257539817 0.461538461538462 9.1 9 1 abnormal soleus morphology 0.0105473576747412 0.0655913805397971 2.41240257539817 0.461538461538462 9.1 9 1 anal atresia 0.0105473576747412 0.0655913805397971 2.41240257539817 0.461538461538462 9.1 9 1 abnormal telomere length 0.0105473576747412 0.0655913805397971 2.41240257539817 0.461538461538462 9.1 9 1 small otic vesicle 0.0105473576747412 0.0655913805397971 2.41240257539817 0.461538461538462 9.1 9 1 increased cochlear inner hair cell number 0.0105473576747412 0.0655913805397971 2.41240257539817 0.461538461538462 9.1 9 1 abnormal exocrine pancreas morphology 0.0105473576747412 0.0655913805397971 2.41240257539817 0.461538461538462 9.1 9 1 abnormal angiogenesis 1.49355135848248e-09 1.32686035865185e-07 2.40153589713061 0.459459459459459 9.1 9 1 abnormal intestine morphology 1.49355135848248e-09 1.32686035865185e-07 2.40153589713061 0.459459459459459 9.1 9 1 decreased body height 0.00058436494813768 0.00741636636985959 2.39564977973568 0.458333333333333 9.1 9 1 ovary cysts 3.56645861226432e-05 0.000768100934892423 2.38942731277533 0.457142857142857 9.1 9 1 decreased glycogen level 3.56645861226432e-05 0.000768100934892423 2.38942731277533 0.457142857142857 9.1 9 1 delayed wound healing 2.27352394640873e-06 8.02183094566201e-05 2.38618080827428 0.456521739130435 9.1 9 1 atrial septal defect 2.27352394640873e-06 8.02183094566201e-05 2.38618080827428 0.456521739130435 9.1 9 1 abnormal tooth development 6.77735171517324e-05 0.00130687305360414 2.37585102122547 0.454545454545455 9.1 9 1 abnormal skeleton physiology 6.77735171517324e-05 0.00130687305360414 2.37585102122547 0.454545454545455 9.1 9 1 increased myocardial infarction size 0.00112524062134868 0.0121170391584625 2.37585102122547 0.454545454545455 9.1 9 1 failure of palatal shelf elevation 0.00112524062134868 0.0121170391584625 2.37585102122547 0.454545454545455 9.1 9 1 increased circulating creatine kinase level 0.00112524062134868 0.0121170391584625 2.37585102122547 0.454545454545455 9.1 9 1 abnormal ear position 0.0210445152329738 0.107380987983636 2.37585102122547 0.454545454545455 9.1 9 1 enlarged cranium 0.0210445152329738 0.107380987983636 2.37585102122547 0.454545454545455 9.1 9 1 abnormal eye distance/ position 0.0210445152329738 0.107380987983636 2.37585102122547 0.454545454545455 9.1 9 1 vasculitis 0.0210445152329738 0.107380987983636 2.37585102122547 0.454545454545455 9.1 9 1 retinal detachment 0.0210445152329738 0.107380987983636 2.37585102122547 0.454545454545455 9.1 9 1 fused joints 0.0210445152329738 0.107380987983636 2.37585102122547 0.454545454545455 9.1 9 1 loss of cortex neurons 0.0210445152329738 0.107380987983636 2.37585102122547 0.454545454545455 9.1 9 1 rectal hemorrhage 0.0210445152329738 0.107380987983636 2.37585102122547 0.454545454545455 9.1 9 1 impaired luteinization 0.0210445152329738 0.107380987983636 2.37585102122547 0.454545454545455 9.1 9 1 pharyngeal arch hypoplasia 0.0210445152329738 0.107380987983636 2.37585102122547 0.454545454545455 9.1 9 1 abnormal Bruch membrane morphology 0.0210445152329738 0.107380987983636 2.37585102122547 0.454545454545455 9.1 9 1 palatal shelf hypoplasia 0.0210445152329738 0.107380987983636 2.37585102122547 0.454545454545455 9.1 9 1 aberrant origin of the right subclavian artery 0.0210445152329738 0.107380987983636 2.37585102122547 0.454545454545455 9.1 9 1 common atrioventricular valve 0.0210445152329738 0.107380987983636 2.37585102122547 0.454545454545455 9.1 9 1 reduced sympathetic cervical ganglion size 0.0210445152329738 0.107380987983636 2.37585102122547 0.454545454545455 9.1 9 1 enlarged kidney 5.24829573232365e-07 2.35227669083875e-05 2.36688554567368 0.452830188679245 9.1 9 1 abnormal basioccipital bone morphology 0.00217268400844928 0.0201286833185013 2.35209251101322 0.45 9.1 9 1 small gonad 0.00217268400844928 0.0201286833185013 2.35209251101322 0.45 9.1 9 1 increased mammary adenocarcinoma incidence 0.00217268400844928 0.0201286833185013 2.35209251101322 0.45 9.1 9 1 dilated vasculature 0.00217268400844928 0.0201286833185013 2.35209251101322 0.45 9.1 9 1 kidney atrophy 0.00217268400844928 0.0201286833185013 2.35209251101322 0.45 9.1 9 1 decreased muscle cell glucose uptake 0.00217268400844928 0.0201286833185013 2.35209251101322 0.45 9.1 9 1 increased mortality induced by gamma-irradiation 0.00024544604863463 0.00378047706488323 2.34308066231202 0.448275862068966 9.1 9 1 abnormal frontal bone morphology 2.89122945024198e-05 0.000642136897989011 2.33833758404823 0.447368421052632 9.1 9 1 incomplete somite formation 2.89122945024198e-05 0.000642136897989011 2.33833758404823 0.447368421052632 9.1 9 1 thin ventricular wall 1.94223243987709e-10 1.97196048742623e-08 2.3230543318649 0.444444444444444 9.1 9 1 decreased tumor growth/size 8.00956017818384e-07 3.40577452021065e-05 2.3230543318649 0.444444444444444 9.1 9 1 abnormal heart valve morphology 0.000467849388592725 0.00629067758986164 2.3230543318649 0.444444444444444 9.1 9 1 increased brain weight 0.000467849388592725 0.00629067758986164 2.3230543318649 0.444444444444444 9.1 9 1 abnormal type II pneumocyte morphology 0.000467849388592725 0.00629067758986164 2.3230543318649 0.444444444444444 9.1 9 1 abnormal eye muscle morphology 0.000467849388592725 0.00629067758986164 2.3230543318649 0.444444444444444 9.1 9 1 abnormal pharyngeal arch morphology 5.46457285512886e-05 0.00108744999817064 2.3230543318649 0.444444444444444 9.1 9 1 delayed kidney development 0.00420860996418497 0.0322120531874157 2.3230543318649 0.444444444444444 9.1 9 1 abnormal bile duct morphology 0.00420860996418497 0.0322120531874157 2.3230543318649 0.444444444444444 9.1 9 1 abnormal anterior eye segment morphology 0.00420860996418497 0.0322120531874157 2.3230543318649 0.444444444444444 9.1 9 1 abnormal glycogen homeostasis 0.00420860996418497 0.0322120531874157 2.3230543318649 0.444444444444444 9.1 9 1 decreased tumor latency 0.00420860996418497 0.0322120531874157 2.3230543318649 0.444444444444444 9.1 9 1 abnormal aerobic respiration 0.00420860996418497 0.0322120531874157 2.3230543318649 0.444444444444444 9.1 9 1 diaphragmatic hernia 0.000892852759877515 0.0103300987916061 2.29982378854626 0.44 9.1 9 1 short humerus 2.31913261372395e-05 0.000533874362647257 2.2947244009885 0.439024390243902 9.1 9 1 abnormal cell differentiation 2.31913261372395e-05 0.000533874362647257 2.2947244009885 0.439024390243902 9.1 9 1 abnormal osteoclast physiology 1.48960666329147e-07 7.52441810204721e-06 2.28675660792952 0.4375 9.1 9 1 failure of primitive streak formation 0.000195418149138707 0.00313614610311312 2.28675660792952 0.4375 9.1 9 1 increased pancreatic beta cell number 0.00818319731542182 0.0543071524889828 2.28675660792952 0.4375 9.1 9 1 bowed radius 0.00818319731542182 0.0543071524889828 2.28675660792952 0.4375 9.1 9 1 abnormal pulmonary alveolus wall morphology 0.00818319731542182 0.0543071524889828 2.28675660792952 0.4375 9.1 9 1 decreased fibroblast apoptosis 0.00818319731542182 0.0543071524889828 2.28675660792952 0.4375 9.1 9 1 decreased adipocyte glucose uptake 0.00818319731542182 0.0543071524889828 2.28675660792952 0.4375 9.1 9 1 abnormal intestinal epithelium morphology 5.26454539011665e-06 0.000160681676784235 2.28675660792952 0.4375 9.1 9 1 decreased circulating total protein level 1.20492319164761e-06 4.87357144589175e-05 2.28081698037645 0.436363636363636 9.1 9 1 abnormal lung development 1.87353301533759e-09 1.5798011442889e-07 2.27522674267945 0.435294117647059 9.1 9 1 abnormal skeleton morphology 3.0526063193022e-12 4.60203528440256e-10 2.27255315073741 0.434782608695652 9.1 9 1 abnormal Wolffian duct morphology 0.00170616459454358 0.0169075515956387 2.27255315073741 0.434782608695652 9.1 9 1 abnormal ulna morphology 0.00170616459454358 0.0169075515956387 2.27255315073741 0.434782608695652 9.1 9 1 abnormal basicranium morphology 0.00170616459454358 0.0169075515956387 2.27255315073741 0.434782608695652 9.1 9 1 muscular ventricular septal defect 5.16656071916597e-07 2.33669450707734e-05 2.26497797356828 0.433333333333333 9.1 9 1 internal hemorrhage 1.19329604204344e-07 6.31043688479702e-06 2.2623775396147 0.432835820895522 9.1 9 1 small lung 4.1951082839776e-06 0.000132934163775723 2.25472920445711 0.431372549019608 9.1 9 1 abnormal scapula morphology 0.00326490783131619 0.0281506351140348 2.24008810572687 0.428571428571429 9.1 9 1 abnormal tumor vascularization 0.00326490783131619 0.0281506351140348 2.24008810572687 0.428571428571429 9.1 9 1 vascular ring 0.00326490783131619 0.0281506351140348 2.24008810572687 0.428571428571429 9.1 9 1 absent segment of posterior cerebral artery 0.00326490783131619 0.0281506351140348 2.24008810572687 0.428571428571429 9.1 9 1 decreased bone volume 0.000154061776581759 0.00255485779498083 2.24008810572687 0.428571428571429 9.1 9 1 impaired adaptive thermogenesis 0.000154061776581759 0.00255485779498083 2.24008810572687 0.428571428571429 9.1 9 1 midline facial cleft 0.0159833165974315 0.0869989059871135 2.24008810572687 0.428571428571429 9.1 9 1 abnormal kidney blood vessel morphology 0.0159833165974315 0.0869989059871135 2.24008810572687 0.428571428571429 9.1 9 1 absent visceral yolk sac blood islands 0.0159833165974315 0.0869989059871135 2.24008810572687 0.428571428571429 9.1 9 1 increased hemangioma incidence 0.0159833165974315 0.0869989059871135 2.24008810572687 0.428571428571429 9.1 9 1 abnormal vascular endothelial cell migration 0.0159833165974315 0.0869989059871135 2.24008810572687 0.428571428571429 9.1 9 1 increased circulating growth hormone level 0.0159833165974315 0.0869989059871135 2.24008810572687 0.428571428571429 9.1 9 1 decreased cornea thickness 0.0159833165974315 0.0869989059871135 2.24008810572687 0.428571428571429 9.1 9 1 testis degeneration 0.0159833165974315 0.0869989059871135 2.24008810572687 0.428571428571429 9.1 9 1 ventricular septal defect 1.59964574765519e-13 3.18329503783382e-11 2.22910728167919 0.426470588235294 9.1 9 1 abnormal mandible morphology 3.3230515344259e-06 0.000108764351209006 2.22626040137053 0.425925925925926 9.1 9 1 abnormal apoptosis 3.3230515344259e-06 0.000108764351209006 2.22626040137053 0.425925925925926 9.1 9 1 extramedullary hematopoiesis 9.65558681736462e-11 1.02205413651891e-08 2.21895519906907 0.424528301886792 9.1 9 1 enlarged pericardium 0.00028947208849753 0.00423565776551532 2.21746095314377 0.424242424242424 9.1 9 1 dilated heart atrium 0.00028947208849753 0.00423565776551532 2.21746095314377 0.424242424242424 9.1 9 1 abnormal snout morphology 6.17102498545126e-06 0.000178493309898954 2.21136902744832 0.423076923076923 9.1 9 1 abnormal stomach morphology 0.00132453609850792 0.0139905883016494 2.21136902744832 0.423076923076923 9.1 9 1 heart inflammation 0.00132453609850792 0.0139905883016494 2.21136902744832 0.423076923076923 9.1 9 1 unresponsive to tactile stimuli 0.00625695862136982 0.044983192400744 2.20078831439833 0.421052631578947 9.1 9 1 abnormal neural crest cell migration 0.00625695862136982 0.044983192400744 2.20078831439833 0.421052631578947 9.1 9 1 increased susceptibility to ischemic brain injury 0.00625695862136982 0.044983192400744 2.20078831439833 0.421052631578947 9.1 9 1 increased circulating VLDL cholesterol level 0.00625695862136982 0.044983192400744 2.20078831439833 0.421052631578947 9.1 9 1 embryonic lethality between implantation and somite formation, incomplete penetrance 0.00625695862136982 0.044983192400744 2.20078831439833 0.421052631578947 9.1 9 1 small kidney 5.96802249002994e-09 4.36631057174985e-07 2.19766219463356 0.420454545454545 9.1 9 1 abnormal capillary morphology 0.000543657834869131 0.00697087043421115 2.19191416796931 0.419354838709677 9.1 9 1 rib fusion 4.74472742007557e-07 2.16559806558495e-05 2.1843645210073 0.417910447761194 9.1 9 1 ocular hypertelorism 0.00250745005626208 0.0228885054200126 2.17786343612335 0.416666666666667 9.1 9 1 abnormal vasodilation 0.00250745005626208 0.0228885054200126 2.17786343612335 0.416666666666667 9.1 9 1 abnormal osteoblast morphology 0.00250745005626208 0.0228885054200126 2.17786343612335 0.416666666666667 9.1 9 1 abnormal supraoccipital bone morphology 0.0313886700762562 0.135099433349204 2.17786343612335 0.416666666666667 9.1 9 1 abnormal glossopharyngeal nerve morphology 0.0313886700762562 0.135099433349204 2.17786343612335 0.416666666666667 9.1 9 1 absent optic nerve 0.0313886700762562 0.135099433349204 2.17786343612335 0.416666666666667 9.1 9 1 impaired embryo implantation 0.0313886700762562 0.135099433349204 2.17786343612335 0.416666666666667 9.1 9 1 abnormal tracheal ciliated epithelium morphology 0.0313886700762562 0.135099433349204 2.17786343612335 0.416666666666667 9.1 9 1 abnormal respiratory function 0.0313886700762562 0.135099433349204 2.17786343612335 0.416666666666667 9.1 9 1 increased growth rate 0.0313886700762562 0.135099433349204 2.17786343612335 0.416666666666667 9.1 9 1 small thyroid gland 0.0313886700762562 0.135099433349204 2.17786343612335 0.416666666666667 9.1 9 1 dilated bile duct 0.0313886700762562 0.135099433349204 2.17786343612335 0.416666666666667 9.1 9 1 small parietal bone 0.0313886700762562 0.135099433349204 2.17786343612335 0.416666666666667 9.1 9 1 increased fibrosarcoma incidence 0.0313886700762562 0.135099433349204 2.17786343612335 0.416666666666667 9.1 9 1 prenatal growth retardation 0.0313886700762562 0.135099433349204 2.17786343612335 0.416666666666667 9.1 9 1 abnormal respiratory motile cilium morphology 0.0313886700762562 0.135099433349204 2.17786343612335 0.416666666666667 9.1 9 1 atrioventricular septal defect 8.95452127650354e-06 0.000250273839048343 2.1696450835342 0.415094339622642 9.1 9 1 abnormal rib morphology 1.65102791772878e-12 2.73795463023357e-10 2.16818404307391 0.414814814814815 9.1 9 1 abnormal mammary gland development 9.37955577599641e-05 0.00174116753677545 2.1672397120447 0.414634146341463 9.1 9 1 short ulna 9.37955577599641e-05 0.00174116753677545 2.1672397120447 0.414634146341463 9.1 9 1 lordosis 0.00102040051800161 0.0112604541042488 2.16284368828801 0.413793103448276 9.1 9 1 decreased trophoblast giant cell number 0.00102040051800161 0.0112604541042488 2.16284368828801 0.413793103448276 9.1 9 1 abnormal embryonic erythropoiesis 0.00102040051800161 0.0112604541042488 2.16284368828801 0.413793103448276 9.1 9 1 failure to gastrulate 3.92910303778217e-05 0.000828274898854504 2.15892549320054 0.41304347826087 9.1 9 1 abnormal lung morphology 5.42149430378012e-11 6.42188908602526e-09 2.15224151334543 0.411764705882353 9.1 9 1 thin skin 0.000419778463976301 0.00580110516189472 2.15224151334543 0.411764705882353 9.1 9 1 abnormal vagus nerve morphology 0.0120091001240371 0.0732172464670156 2.15224151334543 0.411764705882353 9.1 9 1 abnormal dorsal-ventral axis patterning 0.0120091001240371 0.0732172464670156 2.15224151334543 0.411764705882353 9.1 9 1 abnormal cell cytoskeleton morphology 0.0120091001240371 0.0732172464670156 2.15224151334543 0.411764705882353 9.1 9 1 abnormal gluconeogenesis 1.65279305483995e-05 0.000405056426001416 2.15224151334543 0.411764705882353 9.1 9 1 failure of chorioallantoic fusion 1.65279305483995e-05 0.000405056426001416 2.15224151334543 0.411764705882353 9.1 9 1 impaired macrophage chemotaxis 0.000174088184268352 0.00283963513683623 2.14435784479837 0.41025641025641 9.1 9 1 increased hepatocyte apoptosis 0.000174088184268352 0.00283963513683623 2.14435784479837 0.41025641025641 9.1 9 1 abnormal long bone morphology 2.95308944131109e-06 9.89903589323001e-05 2.14216075684264 0.409836065573771 9.1 9 1 abnormal vascular development 1.25303084103064e-06 5.02728099526405e-05 2.13826591910292 0.409090909090909 9.1 9 1 abnormal chorion morphology 0.00474621589975523 0.035776400153458 2.13826591910292 0.409090909090909 9.1 9 1 decreased cardiac output 0.00474621589975523 0.035776400153458 2.13826591910292 0.409090909090909 9.1 9 1 abnormal occipital bone morphology 0.00474621589975523 0.035776400153458 2.13826591910292 0.409090909090909 9.1 9 1 increased bone volume 0.00474621589975523 0.035776400153458 2.13826591910292 0.409090909090909 9.1 9 1 embryonic lethality before implantation, incomplete penetrance 0.00474621589975523 0.035776400153458 2.13826591910292 0.409090909090909 9.1 9 1 abnormal skeletal muscle fiber morphology 5.32755841173909e-07 2.36648241950018e-05 2.13491965005894 0.408450704225352 9.1 9 1 abnormal long bone epiphyseal plate proliferative zone 1.28261567241819e-05 0.000332344425535443 2.12946647087616 0.407407407407407 9.1 9 1 thin epidermis 0.00191350821157461 0.0186336566812502 2.12946647087616 0.407407407407407 9.1 9 1 abnormal blood vessel morphology 1.13880641681999e-12 1.95364204264809e-10 2.12679629348321 0.406896551724138 9.1 9 1 kidney cortex cysts 0.000781927093526789 0.0092842178766009 2.12341685022026 0.40625 9.1 9 1 abnormal heart atrium morphology 0.000781927093526789 0.0092842178766009 2.12341685022026 0.40625 9.1 9 1 increased fibroblast apoptosis 0.000781927093526789 0.0092842178766009 2.12341685022026 0.40625 9.1 9 1 abnormal pulmonary alveolus morphology 3.24059846419837e-09 2.48030420913644e-07 2.12179962489641 0.405940594059406 9.1 9 1 pale liver 4.14352010535558e-07 1.90870486334667e-05 2.11900226217407 0.405405405405405 9.1 9 1 impaired skeletal muscle contractility 0.000322644278745012 0.00462580774281393 2.11900226217407 0.405405405405405 9.1 9 1 increased erythroid progenitor cell number 0.000322644278745012 0.00462580774281393 2.11900226217407 0.405405405405405 9.1 9 1 abnormal muscle morphology 0.000134110922005404 0.00233965013157633 2.11563876651982 0.404761904761905 9.1 9 1 abnormal placenta vasculature 2.35438988329772e-05 0.000537297691257164 2.1108522534734 0.403846153846154 9.1 9 1 abnormal cranium morphology 1.58039145658292e-11 2.03748578028288e-09 2.1063515023999 0.402985074626866 9.1 9 1 lethality throughout fetal growth and development, incomplete penetrance 7.9898062501667e-15 1.98746430472897e-12 2.10242906012354 0.402234636871508 9.1 9 1 small placenta 0.000102988525954919 0.00188300370695499 2.09074889867841 0.4 9.1 9 1 abnormal liver development 0.000596922922239335 0.00753728816786977 2.09074889867841 0.4 9.1 9 1 cardiac fibrosis 1.06221847534914e-07 5.74406186398039e-06 2.09074889867841 0.4 9.1 9 1 disorganized myocardium 0.00145417991995302 0.0151667612196358 2.09074889867841 0.4 9.1 9 1 ruffled hair 0.00358384825385178 0.0301686041673648 2.09074889867841 0.4 9.1 9 1 abnormal cell proliferation 0.00897980836331685 0.057943640217252 2.09074889867841 0.4 9.1 9 1 abnormal vascular regression 0.00897980836331685 0.057943640217252 2.09074889867841 0.4 9.1 9 1 abnormal circulating enzyme level 0.00897980836331685 0.057943640217252 2.09074889867841 0.4 9.1 9 1 abnormal trachea morphology 0.00897980836331685 0.057943640217252 2.09074889867841 0.4 9.1 9 1 decreased skin tensile strength 0.00897980836331685 0.057943640217252 2.09074889867841 0.4 9.1 9 1 abnormal physiological neovascularization 0.00897980836331685 0.057943640217252 2.09074889867841 0.4 9.1 9 1 increased skin tumor incidence 0.00897980836331685 0.057943640217252 2.09074889867841 0.4 9.1 9 1 absent ductus venosus valve 0.00897980836331685 0.057943640217252 2.09074889867841 0.4 9.1 9 1 abnormal fontanelle morphology 0.023082213352096 0.11506413970609 2.09074889867841 0.4 9.1 9 1 vagina atresia 0.023082213352096 0.11506413970609 2.09074889867841 0.4 9.1 9 1 abnormal prostate gland morphology 0.023082213352096 0.11506413970609 2.09074889867841 0.4 9.1 9 1 placental labyrinth hypoplasia 0.023082213352096 0.11506413970609 2.09074889867841 0.4 9.1 9 1 abnormal respiratory system morphology 0.023082213352096 0.11506413970609 2.09074889867841 0.4 9.1 9 1 arthritis 0.023082213352096 0.11506413970609 2.09074889867841 0.4 9.1 9 1 dilated ureter 0.023082213352096 0.11506413970609 2.09074889867841 0.4 9.1 9 1 abnormal placenta size 0.023082213352096 0.11506413970609 2.09074889867841 0.4 9.1 9 1 ostium primum atrial septal defect 0.023082213352096 0.11506413970609 2.09074889867841 0.4 9.1 9 1 abnormal coronary vessel morphology 0.023082213352096 0.11506413970609 2.09074889867841 0.4 9.1 9 1 abnormal branching involved in lung morphogenesis 0.023082213352096 0.11506413970609 2.09074889867841 0.4 9.1 9 1 decreased brown adipose tissue mass 0.023082213352096 0.11506413970609 2.09074889867841 0.4 9.1 9 1 abnormal heart development 5.90867992317247e-13 1.08872898584382e-10 2.08413260469525 0.39873417721519 9.1 9 1 perinatal lethality, incomplete penetrance 7.99471476392733e-18 3.61579145004895e-15 2.08149779735683 0.398230088495575 9.1 9 1 short snout 2.75585902098374e-09 2.14224978584283e-07 2.08106950562898 0.398148148148148 9.1 9 1 abnormal vasculogenesis 0.000188796779690417 0.00304955837324618 2.06643786497285 0.395348837209302 9.1 9 1 kidney failure 0.000188796779690417 0.00304955837324618 2.06643786497285 0.395348837209302 9.1 9 1 abnormal skeleton development 3.48480603586788e-07 1.62027196527502e-05 2.06493718387992 0.395061728395062 9.1 9 1 decreased neuron apoptosis 0.000454441126601866 0.00619409480779256 2.06323904474844 0.394736842105263 9.1 9 1 impaired branching involved in ureteric bud morphogenesis 0.000454441126601866 0.00619409480779256 2.06323904474844 0.394736842105263 9.1 9 1 increased cardiomyocyte apoptosis 0.00110202284679581 0.0119706630192339 2.05907088506207 0.393939393939394 9.1 9 1 increased osteoclast cell number 1.07118276095455e-05 0.000287296086437397 2.05647432656893 0.39344262295082 9.1 9 1 abnormal circulating cholesterol level 0.00269889430529921 0.0243606645510814 2.0534140969163 0.392857142857143 9.1 9 1 premature aging 0.00269889430529921 0.0243606645510814 2.0534140969163 0.392857142857143 9.1 9 1 abnormal myocardium layer morphology 6.29555985592681e-07 2.74740441081016e-05 2.05105113477946 0.392405063291139 9.1 9 1 kidney cysts 1.47894364029379e-06 5.70367799260588e-05 2.04836885343493 0.391891891891892 9.1 9 1 abnormal locomotor behavior 8.82264378233032e-08 4.93175874349363e-06 2.04529783566367 0.391304347826087 9.1 9 1 abnormal cell death 0.000143936915968769 0.00245234985255008 2.04529783566367 0.391304347826087 9.1 9 1 abnormal immune system morphology 0.000143936915968769 0.00245234985255008 2.04529783566367 0.391304347826087 9.1 9 1 abnormal blood vessel physiology 0.00670053459596274 0.046884893973157 2.04529783566367 0.391304347826087 9.1 9 1 increased susceptibility to age related obesity 0.00670053459596274 0.046884893973157 2.04529783566367 0.391304347826087 9.1 9 1 abnormal hematopoietic stem cell physiology 0.00670053459596274 0.046884893973157 2.04529783566367 0.391304347826087 9.1 9 1 abnormal vitelline vasculature morphology 2.28983153130732e-09 1.86752653577933e-07 2.04529783566367 0.391304347826087 9.1 9 1 hemopericardium 0.000345269321885194 0.00493596228844494 2.03975502310089 0.390243902439024 9.1 9 1 lethality throughout fetal growth and development, complete penetrance 2.52170664966466e-14 5.9740431343246e-12 2.03572919081846 0.389473684210526 9.1 9 1 right pulmonary isomerism 0.0169730484075795 0.0903111399226823 2.03267254038179 0.388888888888889 9.1 9 1 absent spleen 0.0169730484075795 0.0903111399226823 2.03267254038179 0.388888888888889 9.1 9 1 thick dermal layer 0.0169730484075795 0.0903111399226823 2.03267254038179 0.388888888888889 9.1 9 1 abnormal metacarpal bone morphology 0.0169730484075795 0.0903111399226823 2.03267254038179 0.388888888888889 9.1 9 1 atrioventricular block 0.0169730484075795 0.0903111399226823 2.03267254038179 0.388888888888889 9.1 9 1 hypoglycemia 1.21769234359902e-07 6.31043688479702e-06 2.02330538581782 0.387096774193548 9.1 9 1 lethargy 1.21769234359902e-07 6.31043688479702e-06 2.02330538581782 0.387096774193548 9.1 9 1 osteopetrosis 0.002029246500006 0.0192295263571997 2.02330538581782 0.387096774193548 9.1 9 1 small cranium 0.002029246500006 0.0192295263571997 2.02330538581782 0.387096774193548 9.1 9 1 abnormal astrocyte morphology 0.000261928496690072 0.003960772860283 2.01947336804165 0.386363636363636 9.1 9 1 muscular atrophy 0.000261928496690072 0.003960772860283 2.01947336804165 0.386363636363636 9.1 9 1 omphalocele 0.000261928496690072 0.003960772860283 2.01947336804165 0.386363636363636 9.1 9 1 embryonic lethality, incomplete penetrance 0.000261928496690072 0.003960772860283 2.01947336804165 0.386363636363636 9.1 9 1 thrombocytopenia 4.92111807390835e-11 5.97135668724245e-09 2.01865410906881 0.386206896551724 9.1 9 1 decreased birth body size 5.65521287335413e-09 4.19920657387116e-07 2.01738928819847 0.385964912280702 9.1 9 1 small liver 1.56228615781783e-06 5.97874895011056e-05 2.01033547949848 0.384615384615385 9.1 9 1 abnormal iris morphology 0.000629661715560314 0.00789059706527093 2.01033547949848 0.384615384615385 9.1 9 1 ventricular hypoplasia 0.00499591835094168 0.0371520086635798 2.01033547949848 0.384615384615385 9.1 9 1 abnormal Schwann cell morphology 0.00499591835094168 0.0371520086635798 2.01033547949848 0.384615384615385 9.1 9 1 increased foot pad pigmentation 0.044414490327203 0.176628368807222 2.01033547949848 0.384615384615385 9.1 9 1 small trigeminal ganglion 0.044414490327203 0.176628368807222 2.01033547949848 0.384615384615385 9.1 9 1 abnormal pulmonary alveolus epithelial cell morphology 0.044414490327203 0.176628368807222 2.01033547949848 0.384615384615385 9.1 9 1 abnormal intercostal muscle morphology 0.044414490327203 0.176628368807222 2.01033547949848 0.384615384615385 9.1 9 1 axonal dystrophy 0.044414490327203 0.176628368807222 2.01033547949848 0.384615384615385 9.1 9 1 muscle fatigue 0.044414490327203 0.176628368807222 2.01033547949848 0.384615384615385 9.1 9 1 increased circulating ammonia level 0.044414490327203 0.176628368807222 2.01033547949848 0.384615384615385 9.1 9 1 small pituitary gland 0.044414490327203 0.176628368807222 2.01033547949848 0.384615384615385 9.1 9 1 abnormal kidney development 2.67142998144078e-05 0.000606865943272506 2.00363436123348 0.383333333333333 9.1 9 1 abnormal tibia morphology 0.000198478863402097 0.00317502361873129 2.00178086043678 0.382978723404255 9.1 9 1 pallor 1.05595932463251e-12 1.87621344287383e-10 2.00114537444934 0.382857142857143 9.1 9 1 short maxilla 0.00152436460758883 0.0157665570119635 1.9985099766779 0.382352941176471 9.1 9 1 overexpanded pulmonary alveoli 0.00152436460758883 0.0157665570119635 1.9985099766779 0.382352941176471 9.1 9 1 abnormal bone remodeling 0.00152436460758883 0.0157665570119635 1.9985099766779 0.382352941176471 9.1 9 1 increased width of hypertrophic chondrocyte zone 0.00152436460758883 0.0157665570119635 1.9985099766779 0.382352941176471 9.1 9 1 hydronephrosis 9.11509637233272e-07 3.77896703769628e-05 1.99118942731278 0.380952380952381 9.1 9 1 small ears 0.0124966702291634 0.0754501630947669 1.99118942731278 0.380952380952381 9.1 9 1 abnormal hematopoietic system physiology 0.0124966702291634 0.0754501630947669 1.99118942731278 0.380952380952381 9.1 9 1 increased muscle cell glucose uptake 0.0124966702291634 0.0754501630947669 1.99118942731278 0.380952380952381 9.1 9 1 abnormal heart morphology 4.63678611023143e-16 1.64771506417153e-13 1.99118942731278 0.380952380952381 9.1 9 1 abnormal embryonic tissue morphology 9.19232028287369e-11 9.94169421897753e-09 1.99118942731278 0.380952380952381 9.1 9 1 decreased embryo size 1.17589432641171e-31 1.46251856847457e-28 1.99014801024828 0.380753138075314 9.1 9 1 abnormal embryo size 1.37803664830438e-08 9.26450314231658e-07 1.98898678414097 0.380530973451327 9.1 9 1 kyphosis 7.04242641738155e-11 7.96274350601664e-09 1.98621145374449 0.38 9.1 9 1 abnormal placenta morphology 2.13334544693529e-06 7.63553496295185e-05 1.98488819494786 0.379746835443038 9.1 9 1 abnormal spinal nerve morphology 0.00372464050864775 0.0308218994821445 1.98260671426401 0.379310344827586 9.1 9 1 decreased bone strength 0.00372464050864775 0.0308218994821445 1.98260671426401 0.379310344827586 9.1 9 1 blood in lymph vessels 0.00372464050864775 0.0308218994821445 1.98260671426401 0.379310344827586 9.1 9 1 embryonic lethality during organogenesis, complete penetrance 2.95790471191749e-36 4.9051919805965e-33 1.97874449339207 0.378571428571429 9.1 9 1 increased circulating phosphate level 0.00114454339234922 0.012219105959093 1.9777354446958 0.378378378378378 9.1 9 1 abnormal humerus morphology 0.00114454339234922 0.012219105959093 1.9777354446958 0.378378378378378 9.1 9 1 increased trabecular bone volume 0.00114454339234922 0.012219105959093 1.9777354446958 0.378378378378378 9.1 9 1 abnormal cartilage development 0.000358427764636411 0.00502303698328491 1.97459618208517 0.377777777777778 9.1 9 1 cardiomyopathy 0.000358427764636411 0.00502303698328491 1.97459618208517 0.377777777777778 9.1 9 1 abnormal cell morphology 1.87012341621518e-08 1.20829402541175e-06 1.9715395316485 0.37719298245614 9.1 9 1 abnormal lipid homeostasis 2.02850533283483e-09 1.68196900514221e-07 1.97012876990851 0.376923076923077 9.1 9 1 abnormal sternum morphology 1.17342207497162e-05 0.000312180471817316 1.96954606397242 0.376811594202899 9.1 9 1 decreased erythrocyte cell number 5.58202851446012e-11 6.45827717661374e-09 1.96423861500042 0.375796178343949 9.1 9 1 abnormal tooth morphology 2.75891082035602e-05 0.000621067028564307 1.96007709251101 0.375 9.1 9 1 pancreatic islet hyperplasia 0.00277763814389352 0.02472048258653 1.96007709251101 0.375 9.1 9 1 abnormal auditory brainstem response waveform shape 0.00277763814389352 0.02472048258653 1.96007709251101 0.375 9.1 9 1 failure of tooth eruption 0.0320216229741005 0.135099433349204 1.96007709251101 0.375 9.1 9 1 poor circulation 0.0320216229741005 0.135099433349204 1.96007709251101 0.375 9.1 9 1 small pancreas 0.0320216229741005 0.135099433349204 1.96007709251101 0.375 9.1 9 1 bowed tibia 0.0320216229741005 0.135099433349204 1.96007709251101 0.375 9.1 9 1 kidney degeneration 0.0320216229741005 0.135099433349204 1.96007709251101 0.375 9.1 9 1 perinatal lethality 0.000859178813609341 0.0100103386363149 1.96007709251101 0.375 9.1 9 1 hydrops fetalis 8.90908875363946e-06 0.000250273839048343 1.96007709251101 0.375 9.1 9 1 abnormal cardiovascular system morphology 0.000270231650047793 0.00402050289119169 1.96007709251101 0.375 9.1 9 1 abnormal foregut morphology 0.00921638531978313 0.0590109613461018 1.96007709251101 0.375 9.1 9 1 decreased metastatic potential 0.00921638531978313 0.0590109613461018 1.96007709251101 0.375 9.1 9 1 abnormal inner cell mass apoptosis 0.00921638531978313 0.0590109613461018 1.96007709251101 0.375 9.1 9 1 embryonic lethality during organogenesis, incomplete penetrance 3.59091462394357e-15 9.92488903006625e-13 1.95439570963417 0.373913043478261 9.1 9 1 decreased circulating serum albumin level 2.34376713442563e-07 1.12117706670841e-05 1.95347750634094 0.373737373737374 9.1 9 1 increased mean corpuscular hemoglobin 2.34376713442563e-07 1.12117706670841e-05 1.95347750634094 0.373737373737374 9.1 9 1 abnormal neurocranium morphology 6.76108635457469e-06 0.000192208026365766 1.95136563876652 0.373333333333333 9.1 9 1 abnormal extraembryonic tissue morphology 1.78373250089264e-07 8.78620712073357e-06 1.94726613112205 0.372549019607843 9.1 9 1 edema 1.44832186935326e-11 1.94740575676553e-09 1.94488269644504 0.372093023255814 9.1 9 1 decreased oxygen consumption 0.000644941055033797 0.00801523240561678 1.94488269644504 0.372093023255814 9.1 9 1 embryonic lethality between somite formation and embryo turning, complete penetrance 1.58302458183423e-05 0.000393777364731263 1.94140969162996 0.371428571428571 9.1 9 1 thick pulmonary interalveolar septum 0.0020723983307499 0.0194899464942925 1.94140969162996 0.371428571428571 9.1 9 1 abnormal embryonic epiblast morphology 0.0020723983307499 0.0194899464942925 1.94140969162996 0.371428571428571 9.1 9 1 abnormal muscle physiology 1.26722359074044e-06 5.04354989114697e-05 1.93805375439291 0.370786516853933 9.1 9 1 abnormal maxilla morphology 0.00015349975217005 0.00255485779498083 1.93587860988742 0.37037037037037 9.1 9 1 abnormal trigeminal nerve morphology 0.0068091007858635 0.047510906605429 1.93587860988742 0.37037037037037 9.1 9 1 abnormal bone trabecula morphology 0.0068091007858635 0.047510906605429 1.93587860988742 0.37037037037037 9.1 9 1 hemorrhage 4.93150472482616e-15 1.29127557926369e-12 1.93505483175555 0.370212765957447 9.1 9 1 anemia 1.35599841013279e-13 2.81087170433775e-11 1.93220869783076 0.369668246445498 9.1 9 1 abnormal forelimb morphology 0.000484163779372617 0.00644041391010366 1.9316701781268 0.369565217391304 9.1 9 1 abnormal myelin sheath morphology 0.000484163779372617 0.00644041391010366 1.9316701781268 0.369565217391304 9.1 9 1 incomplete embryo turning 0.000115671227811641 0.00207748865834987 1.92568977509854 0.368421052631579 9.1 9 1 abnormal craniofacial bone morphology 0.000115671227811641 0.00207748865834987 1.92568977509854 0.368421052631579 9.1 9 1 decreased hair follicle number 0.00154710304736852 0.0159354816990857 1.92568977509854 0.368421052631579 9.1 9 1 kyphoscoliosis 0.0232241007828685 0.115194318439452 1.92568977509854 0.368421052631579 9.1 9 1 enlarged adrenal glands 0.0232241007828685 0.115194318439452 1.92568977509854 0.368421052631579 9.1 9 1 increased malignant tumor incidence 0.0232241007828685 0.115194318439452 1.92568977509854 0.368421052631579 9.1 9 1 decreased germ cell number 0.0232241007828685 0.115194318439452 1.92568977509854 0.368421052631579 9.1 9 1 abnormal optic vesicle formation 0.0232241007828685 0.115194318439452 1.92568977509854 0.368421052631579 9.1 9 1 embryonic lethality before implantation, complete penetrance 1.492151981558e-08 9.79540887163297e-07 1.92348898678414 0.368 9.1 9 1 abnormal somite development 6.86649433244035e-06 0.00019409550740847 1.91872525511627 0.367088607594937 9.1 9 1 absent mesoderm 8.71633925411697e-05 0.00163021758606135 1.91651982378855 0.366666666666667 9.1 9 1 abnormal heart tube morphology 0.00503911769157632 0.037305968029155 1.91651982378855 0.366666666666667 9.1 9 1 delayed eyelid opening 0.00503911769157632 0.037305968029155 1.91651982378855 0.366666666666667 9.1 9 1 abnormal optic cup morphology 0.00503911769157632 0.037305968029155 1.91651982378855 0.366666666666667 9.1 9 1 abnormal ovary morphology 2.11813764463215e-05 0.000497392431469222 1.91406589315629 0.366197183098592 9.1 9 1 increased tumor growth/size 0.00115566505883481 0.0123114211299854 1.91227033415709 0.365853658536585 9.1 9 1 distended pericardium 0.000273001292122707 0.00402050289119169 1.90981870552355 0.365384615384615 9.1 9 1 decreased kidney weight 0.000273001292122707 0.00402050289119169 1.90981870552355 0.365384615384615 9.1 9 1 decreased susceptibility to hepatic steatosis 6.56829240677355e-05 0.0012814609695568 1.90822320117474 0.365079365079365 9.1 9 1 abnormal contextual conditioning behavior 0.000205068662248135 0.00324909743530087 1.90068081698038 0.363636363636364 9.1 9 1 abnormal embryo turning 0.000205068662248135 0.00324909743530087 1.90068081698038 0.363636363636364 9.1 9 1 abnormal joint morphology 0.000205068662248135 0.00324909743530087 1.90068081698038 0.363636363636364 9.1 9 1 renal interstitial fibrosis 0.000863805374087356 0.0100173233941366 1.90068081698038 0.363636363636364 9.1 9 1 dextrocardia 0.00373513259937794 0.0308218994821445 1.90068081698038 0.363636363636364 9.1 9 1 abnormal locomotor coordination 0.00373513259937794 0.0308218994821445 1.90068081698038 0.363636363636364 9.1 9 1 increased osteoblast cell number 0.00373513259937794 0.0308218994821445 1.90068081698038 0.363636363636364 9.1 9 1 abnormal abdominal fat pad morphology 0.0169255012745395 0.0903111399226823 1.90068081698038 0.363636363636364 9.1 9 1 abnormal facial nerve morphology 0.0169255012745395 0.0903111399226823 1.90068081698038 0.363636363636364 9.1 9 1 increased body size 0.0169255012745395 0.0903111399226823 1.90068081698038 0.363636363636364 9.1 9 1 abnormal tail movements 0.0169255012745395 0.0903111399226823 1.90068081698038 0.363636363636364 9.1 9 1 abnormal germ layer development 0.0169255012745395 0.0903111399226823 1.90068081698038 0.363636363636364 9.1 9 1 intracerebral hemorrhage 0.0169255012745395 0.0903111399226823 1.90068081698038 0.363636363636364 9.1 9 1 increased skin papilloma incidence 0.0169255012745395 0.0903111399226823 1.90068081698038 0.363636363636364 9.1 9 1 abnormal cochlear sensory epithelium morphology 0.0169255012745395 0.0903111399226823 1.90068081698038 0.363636363636364 9.1 9 1 prolonged PR interval 0.0169255012745395 0.0903111399226823 1.90068081698038 0.363636363636364 9.1 9 1 abnormal circulating lipid level 0.0169255012745395 0.0903111399226823 1.90068081698038 0.363636363636364 9.1 9 1 abnormal mesenteric lymph node morphology 0.0169255012745395 0.0903111399226823 1.90068081698038 0.363636363636364 9.1 9 1 cleft secondary palate 1.70191276114471e-06 6.31866864678725e-05 1.89057081263474 0.361702127659574 9.1 9 1 abnormal cell nucleus morphology 0.000646051898422578 0.00801523240561678 1.89057081263474 0.361702127659574 9.1 9 1 increased respiratory quotient 0.000646051898422578 0.00801523240561678 1.89057081263474 0.361702127659574 9.1 9 1 decreased body length 4.34149293451414e-16 1.64771506417153e-13 1.88854143220039 0.361313868613139 9.1 9 1 abnormal systemic arterial blood pressure 0.00277261438720901 0.02472048258653 1.88748164464023 0.361111111111111 9.1 9 1 impaired wound healing 0.00277261438720901 0.02472048258653 1.88748164464023 0.361111111111111 9.1 9 1 abnormal egg cylinder morphology 0.0123846874193695 0.0750875384298947 1.88167400881057 0.36 9.1 9 1 abnormal energy expenditure 0.0123846874193695 0.0750875384298947 1.88167400881057 0.36 9.1 9 1 decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 0.0123846874193695 0.0750875384298947 1.88167400881057 0.36 9.1 9 1 abnormal limb morphology 2.11954161751709e-05 0.000497392431469222 1.88167400881057 0.36 9.1 9 1 abnormal eye morphology 8.69923485112371e-09 6.18267048347721e-07 1.88016987291224 0.359712230215827 9.1 9 1 abnormal heart looping 0.00206087019318109 0.0194550838919847 1.87631311419858 0.358974358974359 9.1 9 1 abnormal femur morphology 6.54596642027559e-05 0.0012814609695568 1.87231244657768 0.358208955223881 9.1 9 1 abnormal neural tube morphology 7.22423504454224e-10 7.04717046011718e-08 1.87134932289117 0.358024691358025 9.1 9 1 decreased heart weight 1.20477858371382e-05 0.00031676586664049 1.87134932289117 0.358024691358025 9.1 9 1 abnormal cytotoxic T cell physiology 0.0015336940067539 0.015830140422408 1.86674008810573 0.357142857142857 9.1 9 1 cardiac hypertrophy 1.6947833149801e-06 6.31866864678725e-05 1.86674008810573 0.357142857142857 9.1 9 1 abnormal jaw morphology 0.00909254883062142 0.0584437085689168 1.86674008810573 0.357142857142857 9.1 9 1 lymphoid hyperplasia 0.00909254883062142 0.0584437085689168 1.86674008810573 0.357142857142857 9.1 9 1 abnormal mitotic spindle morphology 0.00909254883062142 0.0584437085689168 1.86674008810573 0.357142857142857 9.1 9 1 megacephaly 0.0602095868437429 0.221391496339705 1.86674008810573 0.357142857142857 9.1 9 1 abnormal adrenal gland secretion 0.0602095868437429 0.221391496339705 1.86674008810573 0.357142857142857 9.1 9 1 abnormal fluid regulation 0.0602095868437429 0.221391496339705 1.86674008810573 0.357142857142857 9.1 9 1 abnormal antigen presentation 0.0602095868437429 0.221391496339705 1.86674008810573 0.357142857142857 9.1 9 1 abnormal spleen periarteriolar lymphoid sheath morphology 0.0602095868437429 0.221391496339705 1.86674008810573 0.357142857142857 9.1 9 1 absent otoliths 0.0602095868437429 0.221391496339705 1.86674008810573 0.357142857142857 9.1 9 1 decreased vascular permeability 0.0602095868437429 0.221391496339705 1.86674008810573 0.357142857142857 9.1 9 1 intestinal obstruction 0.0602095868437429 0.221391496339705 1.86674008810573 0.357142857142857 9.1 9 1 abnormal pancreas development 0.0602095868437429 0.221391496339705 1.86674008810573 0.357142857142857 9.1 9 1 abnormal squamosal bone morphology 0.0602095868437429 0.221391496339705 1.86674008810573 0.357142857142857 9.1 9 1 abnormal viscerocranium morphology 0.0602095868437429 0.221391496339705 1.86674008810573 0.357142857142857 9.1 9 1 abnormal glucose tolerance 0.0602095868437429 0.221391496339705 1.86674008810573 0.357142857142857 9.1 9 1 increased pulmonary respiratory rate 0.0602095868437429 0.221391496339705 1.86674008810573 0.357142857142857 9.1 9 1 decreased tongue size 0.0602095868437429 0.221391496339705 1.86674008810573 0.357142857142857 9.1 9 1 increased stomach tumor incidence 0.0602095868437429 0.221391496339705 1.86674008810573 0.357142857142857 9.1 9 1 increased lung compliance 0.0602095868437429 0.221391496339705 1.86674008810573 0.357142857142857 9.1 9 1 decreased compact bone area 0.0602095868437429 0.221391496339705 1.86674008810573 0.357142857142857 9.1 9 1 abnormal vitelline vein topology 0.0602095868437429 0.221391496339705 1.86674008810573 0.357142857142857 9.1 9 1 abnormal cell cycle 2.40962765610253e-07 1.1417045322962e-05 1.86349358360467 0.356521739130435 9.1 9 1 prenatal lethality, complete penetrance 1.29349656492586e-15 3.7853796532389e-13 1.86136817418312 0.356115107913669 9.1 9 1 oxidative stress 5.1676179071941e-06 0.000159682603032861 1.85844346549192 0.355555555555556 9.1 9 1 altered response to myocardial infarction 0.00114263439999132 0.012219105959093 1.85844346549192 0.355555555555556 9.1 9 1 abnormal axial skeleton morphology 2.78752363729022e-05 0.000624681535834182 1.85691514027359 0.355263157894737 9.1 9 1 embryonic lethality between implantation and somite formation, complete penetrance 8.02343535802073e-14 1.81439049573423e-11 1.85607300188798 0.355102040816327 9.1 9 1 abnormal cranial ganglia morphology 0.00669454684693997 0.046884893973157 1.85469660366634 0.354838709677419 9.1 9 1 abnormal postnatal growth/weight/body size 0.00669454684693997 0.046884893973157 1.85469660366634 0.354838709677419 9.1 9 1 preaxial polydactyly 0.00669454684693997 0.046884893973157 1.85469660366634 0.354838709677419 9.1 9 1 abnormal definitive hematopoiesis 3.89811242584741e-06 0.0001243148033243 1.85469660366633 0.354838709677419 9.1 9 1 decreased hemoglobin content 1.49638406883237e-08 9.79540887163297e-07 1.85350079670072 0.354609929078014 9.1 9 1 abnormal osteoclast morphology 0.000852146873337784 0.00997203437414913 1.85118392070485 0.354166666666667 9.1 9 1 enlarged heart 5.46425522212772e-13 1.0455642203879e-10 1.84742898374601 0.353448275862069 9.1 9 1 kinked tail 1.67433818450298e-06 6.31866864678725e-05 1.84477844001037 0.352941176470588 9.1 9 1 increased kidney weight 0.000636095896002066 0.00795119870002583 1.84477844001037 0.352941176470588 9.1 9 1 lung hemorrhage 0.00494100604944474 0.036853830728617 1.84477844001037 0.352941176470588 9.1 9 1 abnormal direction of heart looping 0.00494100604944474 0.036853830728617 1.84477844001037 0.352941176470588 9.1 9 1 decreased osteoblast cell number 0.00494100604944474 0.036853830728617 1.84477844001037 0.352941176470588 9.1 9 1 hydroureter 0.0429375445286805 0.172408623107494 1.84477844001037 0.352941176470588 9.1 9 1 decreased vasoconstriction 0.0429375445286805 0.172408623107494 1.84477844001037 0.352941176470588 9.1 9 1 decreased liver weight 6.44824437072209e-05 0.00127301649779137 1.84044797418874 0.352112676056338 9.1 9 1 abnormal axon morphology 9.53681395081989e-07 3.8889876561745e-05 1.83908467939305 0.351851851851852 9.1 9 1 abnormal osteoblast physiology 0.000475223639505608 0.00637260810388248 1.83908467939305 0.351851851851852 9.1 9 1 small spleen 6.75009710667868e-06 0.000192208026365766 1.83802100982718 0.351648351648352 9.1 9 1 abnormal long bone metaphysis morphology 0.00365448617609138 0.0306594750860955 1.83646862721753 0.351351351351351 9.1 9 1 decreased brain weight 0.000355312619750586 0.00502181898653172 1.83399026199861 0.350877192982456 9.1 9 1 abnormal facial morphology 0.000355312619750586 0.00502181898653172 1.83399026199861 0.350877192982456 9.1 9 1 intracranial hemorrhage 0.000265847978052359 0.00397175282525672 1.82940528634361 0.35 9.1 9 1 increased erythrocyte cell number 0.000265847978052359 0.00397175282525672 1.82940528634361 0.35 9.1 9 1 abnormal fibula morphology 0.0308941043933963 0.135099433349204 1.82940528634361 0.35 9.1 9 1 abnormal Peyer's patch T cell area morphology 0.0308941043933963 0.135099433349204 1.82940528634361 0.35 9.1 9 1 abnormal hyoid bone morphology 0.0308941043933963 0.135099433349204 1.82940528634361 0.35 9.1 9 1 abnormal optic stalk morphology 0.0308941043933963 0.135099433349204 1.82940528634361 0.35 9.1 9 1 decreased circulating VLDL cholesterol level 0.0308941043933963 0.135099433349204 1.82940528634361 0.35 9.1 9 1 prenatal lethality, incomplete penetrance 6.88630767052524e-16 2.14121129130394e-13 1.82252782286112 0.348684210526316 9.1 9 1 embryonic lethality, complete penetrance 1.70678633034531e-16 7.07605166122325e-14 1.81875491969674 0.347962382445141 9.1 9 1 abnormal cranial nerve morphology 0.0223788168364472 0.113030064732309 1.81804252058993 0.347826086956522 9.1 9 1 abnormal postnatal growth 0.0223788168364472 0.113030064732309 1.81804252058993 0.347826086956522 9.1 9 1 abnormal nasal cavity morphology 0.0223788168364472 0.113030064732309 1.81804252058993 0.347826086956522 9.1 9 1 abnormal cardiovascular development 0.0223788168364472 0.113030064732309 1.81804252058993 0.347826086956522 9.1 9 1 decreased grip strength 1.06486421343035e-11 1.47158318383777e-09 1.81389173857945 0.34703196347032 9.1 9 1 respiratory distress 1.54574262863182e-09 1.34913501358654e-07 1.81278806243793 0.346820809248555 9.1 9 1 increased urine protein level 4.72148447609785e-05 0.00095485305969865 1.80930193154863 0.346153846153846 9.1 9 1 abnormal heart ventricle morphology 4.72148447609785e-05 0.00095485305969865 1.80930193154863 0.346153846153846 9.1 9 1 kinked neural tube 0.000828322450997027 0.00976517581447917 1.80930193154863 0.346153846153846 9.1 9 1 abnormal nasal bone morphology 0.0162963886908901 0.0882203849153193 1.80930193154863 0.346153846153846 9.1 9 1 decreased bone resorption 0.0162963886908901 0.0882203849153193 1.80930193154863 0.346153846153846 9.1 9 1 abnormal nerve conduction 0.0162963886908901 0.0882203849153193 1.80930193154863 0.346153846153846 9.1 9 1 abnormal head morphology 0.000617805433058161 0.00776157078147564 1.80564677613136 0.345454545454545 9.1 9 1 abnormal platelet physiology 0.000617805433058161 0.00776157078147564 1.80564677613136 0.345454545454545 9.1 9 1 glomerulosclerosis 0.000461224779939928 0.00626938054699765 1.80236974024001 0.344827586206897 9.1 9 1 short sternum 0.0119177637369234 0.0731986106064121 1.80236974024001 0.344827586206897 9.1 9 1 decreased caudal vertebrae number 0.000257701168501998 0.00394481019476136 1.79673733480176 0.34375 9.1 9 1 scoliosis 0.00874626092948809 0.0574803806132144 1.79673733480176 0.34375 9.1 9 1 abnormal embryonic hematopoiesis 0.00874626092948809 0.0574803806132144 1.79673733480176 0.34375 9.1 9 1 abnormal kidney morphology 2.55926891725927e-09 2.02100997831189e-07 1.7920704845815 0.342857142857143 9.1 9 1 increased circulating serum albumin level 0.00643767094615507 0.0461490100246707 1.7920704845815 0.342857142857143 9.1 9 1 abnormal midbrain development 0.00643767094615507 0.0461490100246707 1.7920704845815 0.342857142857143 9.1 9 1 increased insulin sensitivity 7.20138837910659e-08 4.16591944023899e-06 1.79102615446228 0.342657342657343 9.1 9 1 preweaning lethality, incomplete penetrance 1.07906344976055e-19 5.9648229583986e-17 1.78914942429693 0.342298288508557 9.1 9 1 liver inflammation 8.81232649255174e-07 3.68414489919705e-05 1.78584801762115 0.341666666666667 9.1 9 1 palatal shelves fail to meet at midline 0.00351281537947204 0.0296710636890889 1.78478564521328 0.341463414634146 9.1 9 1 lethality at weaning, incomplete penetrance 0.00351281537947204 0.0296710636890889 1.78478564521328 0.341463414634146 9.1 9 1 decreased sensitivity to induced morbidity/mortality 0.00260257353120615 0.0236489855674482 1.7818882659191 0.340909090909091 9.1 9 1 thymus hypoplasia 1.62032850794678e-07 8.06113432703524e-06 1.7801666347443 0.340579710144928 9.1 9 1 decreased bone trabecula number 0.00193137580586042 0.0187302039652156 1.77936076483269 0.340425531914894 9.1 9 1 increased B cell derived lymphoma incidence 0.00143537044302768 0.0150020335169385 1.77713656387665 0.34 9.1 9 1 decreased oocyte number 0.00143537044302768 0.0150020335169385 1.77713656387665 0.34 9.1 9 1 short mandible 0.000795777669069975 0.00942617596100744 1.77340308370044 0.339285714285714 9.1 9 1 abnormal thoracic vertebrae morphology 0.000593489603948379 0.00751300452835416 1.77182110057493 0.338983050847458 9.1 9 1 polydactyly 1.39560114866062e-05 0.000359746928216921 1.76006922592826 0.336734693877551 9.1 9 1 abnormal dendritic cell physiology 5.93665104470017e-06 0.000173734346749314 1.75857384000988 0.336448598130841 9.1 9 1 decreased hematocrit 1.49732139116115e-07 7.52441810204721e-06 1.75422424717881 0.335616438356164 9.1 9 1 abnormal brain morphology 3.66091112575389e-08 2.24852257415131e-06 1.75311243056886 0.335403726708075 9.1 9 1 decreased bone mineral density 1.99102592970612e-12 3.09542312508998e-10 1.7488407141201 0.334586466165414 9.1 9 1 insulin resistance 7.79165123224391e-07 3.34167800693219e-05 1.74229074889868 0.333333333333333 9.1 9 1 increased rib number 0.000132241425812309 0.00231655314583183 1.74229074889868 0.333333333333333 9.1 9 1 decreased spleen weight 0.000315385257049016 0.00454794682266334 1.74229074889868 0.333333333333333 9.1 9 1 abnormal eating behavior 0.00075731041689639 0.00912256494929671 1.74229074889868 0.333333333333333 9.1 9 1 abnormal long bone epiphyseal plate morphology 0.00075731041689639 0.00912256494929671 1.74229074889868 0.333333333333333 9.1 9 1 abnormal chondrocyte morphology 0.00136458742359861 0.0143224101949432 1.74229074889868 0.333333333333333 9.1 9 1 abnormal small intestine morphology 0.00136458742359861 0.0143224101949432 1.74229074889868 0.333333333333333 9.1 9 1 decreased platelet aggregation 0.00136458742359861 0.0143224101949432 1.74229074889868 0.333333333333333 9.1 9 1 abnormal myocardial trabeculae morphology 0.00333254309681357 0.0283893868264512 1.74229074889868 0.333333333333333 9.1 9 1 abnormal cartilage morphology 0.0045023760658311 0.0342497261888528 1.74229074889868 0.333333333333333 9.1 9 1 disheveled coat 0.0045023760658311 0.0342497261888528 1.74229074889868 0.333333333333333 9.1 9 1 skin edema 0.0045023760658311 0.0342497261888528 1.74229074889868 0.333333333333333 9.1 9 1 small lens 0.00609505300795038 0.0441381203996407 1.74229074889868 0.333333333333333 9.1 9 1 abnormal response to injury 0.00609505300795038 0.0441381203996407 1.74229074889868 0.333333333333333 9.1 9 1 single kidney 0.0112518250945432 0.0692794923828616 1.74229074889868 0.333333333333333 9.1 9 1 abnormal QRS complex 0.0112518250945432 0.0692794923828616 1.74229074889868 0.333333333333333 9.1 9 1 abnormal middle ear ossicle morphology 0.0112518250945432 0.0692794923828616 1.74229074889868 0.333333333333333 9.1 9 1 increased metastatic potential 0.0153570867595969 0.0848931745816101 1.74229074889868 0.333333333333333 9.1 9 1 abnormal microglial cell physiology 0.0153570867595969 0.0848931745816101 1.74229074889868 0.333333333333333 9.1 9 1 abnormal skin appearance 0.0210400326434034 0.107380987983636 1.74229074889868 0.333333333333333 9.1 9 1 thick interventricular septum 0.0210400326434034 0.107380987983636 1.74229074889868 0.333333333333333 9.1 9 1 absent incisors 0.0787732735895662 0.258166690453288 1.74229074889868 0.333333333333333 9.1 9 1 abnormal epidermis stratum spinosum morphology 0.0787732735895662 0.258166690453288 1.74229074889868 0.333333333333333 9.1 9 1 abnormal glial cell morphology 0.0787732735895662 0.258166690453288 1.74229074889868 0.333333333333333 9.1 9 1 abnormal trophectoderm morphology 0.0787732735895662 0.258166690453288 1.74229074889868 0.333333333333333 9.1 9 1 abnormal olfactory nerve morphology 0.0787732735895662 0.258166690453288 1.74229074889868 0.333333333333333 9.1 9 1 immune system phenotype 0.0787732735895662 0.258166690453288 1.74229074889868 0.333333333333333 9.1 9 1 abnormal cerebral aqueduct morphology 0.0787732735895662 0.258166690453288 1.74229074889868 0.333333333333333 9.1 9 1 abnormal Muller cell morphology 0.0787732735895662 0.258166690453288 1.74229074889868 0.333333333333333 9.1 9 1 decreased thymocyte apoptosis 0.0787732735895662 0.258166690453288 1.74229074889868 0.333333333333333 9.1 9 1 decreased trabecular bone mass 0.0787732735895662 0.258166690453288 1.74229074889868 0.333333333333333 9.1 9 1 herniated liver 0.0787732735895662 0.258166690453288 1.74229074889868 0.333333333333333 9.1 9 1 perinatal lethality, complete penetrance 3.91242384106221e-10 3.8928617218569e-08 1.74229074889868 0.333333333333333 9.1 9 1 abnormal digit morphology 0.000235898817666654 0.00365606423019191 1.74229074889868 0.333333333333333 9.1 9 1 absent vitelline blood vessels 0.00101601019372967 0.0112604541042488 1.74229074889868 0.333333333333333 9.1 9 1 increased hepatocellular carcinoma incidence 0.00101601019372967 0.0112604541042488 1.74229074889868 0.333333333333333 9.1 9 1 increased macrophage cell number 0.00101601019372967 0.0112604541042488 1.74229074889868 0.333333333333333 9.1 9 1 vertebral transformation 0.00247099027212175 0.0227230621142435 1.74229074889868 0.333333333333333 9.1 9 1 abnormal epidermis stratum granulosum morphology 0.00827019922562809 0.0547130866323135 1.74229074889868 0.333333333333333 9.1 9 1 abnormal retinal blood vessel morphology 0.00827019922562809 0.0547130866323135 1.74229074889868 0.333333333333333 9.1 9 1 abnormal malleus morphology 0.0289600325947791 0.129112596731005 1.74229074889868 0.333333333333333 9.1 9 1 abnormal digestive system morphology 0.0289600325947791 0.129112596731005 1.74229074889868 0.333333333333333 9.1 9 1 abnormal adrenal gland morphology 0.0289600325947791 0.129112596731005 1.74229074889868 0.333333333333333 9.1 9 1 abnormal impulse conducting system conduction 0.0289600325947791 0.129112596731005 1.74229074889868 0.333333333333333 9.1 9 1 decreased ovulation rate 0.0289600325947791 0.129112596731005 1.74229074889868 0.333333333333333 9.1 9 1 abnormal lung saccule morphology 0.0289600325947791 0.129112596731005 1.74229074889868 0.333333333333333 9.1 9 1 lowered ear position 0.055919792589231 0.211417716286054 1.74229074889868 0.333333333333333 9.1 9 1 abnormal mammary gland morphology 0.055919792589231 0.211417716286054 1.74229074889868 0.333333333333333 9.1 9 1 blepharoptosis 0.055919792589231 0.211417716286054 1.74229074889868 0.333333333333333 9.1 9 1 eye inflammation 0.055919792589231 0.211417716286054 1.74229074889868 0.333333333333333 9.1 9 1 abnormal thyroid cartilage morphology 0.055919792589231 0.211417716286054 1.74229074889868 0.333333333333333 9.1 9 1 abnormal thymus medulla morphology 0.055919792589231 0.211417716286054 1.74229074889868 0.333333333333333 9.1 9 1 absent allantois 0.055919792589231 0.211417716286054 1.74229074889868 0.333333333333333 9.1 9 1 abnormal redox activity 0.055919792589231 0.211417716286054 1.74229074889868 0.333333333333333 9.1 9 1 absent ureter 0.055919792589231 0.211417716286054 1.74229074889868 0.333333333333333 9.1 9 1 absent inner cell mass 0.055919792589231 0.211417716286054 1.74229074889868 0.333333333333333 9.1 9 1 small thoracic cage 0.055919792589231 0.211417716286054 1.74229074889868 0.333333333333333 9.1 9 1 abnormal macrophage chemotaxis 0.055919792589231 0.211417716286054 1.74229074889868 0.333333333333333 9.1 9 1 abnormal metanephric mesenchyme morphology 0.055919792589231 0.211417716286054 1.74229074889868 0.333333333333333 9.1 9 1 decreased bone mineral content 8.65953548289348e-10 8.12852623158398e-08 1.73391435106743 0.331730769230769 9.1 9 1 increased blood urea nitrogen level 3.17950216152954e-07 1.49226634468014e-05 1.73027495063041 0.331034482758621 9.1 9 1 abnormal craniofacial morphology 1.68472560901775e-05 0.000410858328669771 1.72537530473461 0.330097087378641 9.1 9 1 decreased cell proliferation 1.03077373743139e-08 7.12236019961271e-07 1.72345517323491 0.32972972972973 9.1 9 1 increased thermal nociceptive threshold 5.28992917462586e-05 0.00105692360015115 1.72314469671298 0.32967032967033 9.1 9 1 increased grip strength 5.28992917462586e-05 0.00105692360015115 1.72314469671298 0.32967032967033 9.1 9 1 abnormal visceral yolk sac morphology 0.000167270611298891 0.00274643990499004 1.72023643562148 0.329113924050633 9.1 9 1 decreased bone marrow cell number 0.000298449312235413 0.00435420917410903 1.71842375233842 0.328767123287671 9.1 9 1 decreased circulating calcium level 0.00172788677034803 0.0170560251636537 1.71061273528234 0.327272727272727 9.1 9 1 increased susceptibility to injury 0.00232396913123304 0.0214503644302122 1.7087851575737 0.326923076923077 9.1 9 1 impaired glucose tolerance 7.46723748990954e-11 8.25544589162222e-09 1.70716391928379 0.326612903225806 9.1 9 1 abnormal long bone hypertrophic chondrocyte zone 0.00313002670996831 0.027176060876252 1.70673379483952 0.326530612244898 9.1 9 1 absent kidney 0.00313002670996831 0.027176060876252 1.70673379483952 0.326530612244898 9.1 9 1 increased sensitivity to induced morbidity/mortality 2.14903986404052e-08 1.37070170815405e-06 1.70441486305306 0.326086956521739 9.1 9 1 increased oxygen consumption 0.000118175078469022 0.00209224560634656 1.70177235938941 0.325581395348837 9.1 9 1 increased susceptibility to weight loss 0.00772588770924661 0.0518708385337407 1.69873348017621 0.325 9.1 9 1 increased granulocyte number 0.000375140087908065 0.0051986683491438 1.69520180973925 0.324324324324324 9.1 9 1 increased white adipose tissue amount 0.0104857414894057 0.0655913805397971 1.69520180973925 0.324324324324324 9.1 9 1 abnormal branching of the mammary ductal tree 0.0104857414894057 0.0655913805397971 1.69520180973925 0.324324324324324 9.1 9 1 skin inflammation 0.0104857414894057 0.0655913805397971 1.69520180973925 0.324324324324324 9.1 9 1 abnormal respiratory electron transport chain 0.0104857414894057 0.0655913805397971 1.69520180973925 0.324324324324324 9.1 9 1 increased circulating free fatty acid level 0.000501529917935321 0.00653170508305817 1.69321213625365 0.323943661971831 9.1 9 1 decreased mean corpuscular hemoglobin 0.000671002378764147 0.00820205610405806 1.69104690334284 0.323529411764706 9.1 9 1 abnormal cardiovascular system physiology 2.57808873559564e-06 8.89257556341497e-05 1.68989102712729 0.323308270676692 9.1 9 1 prenatal lethality 0.00120413437719261 0.0127730672207532 1.68608782151485 0.32258064516129 9.1 9 1 pericardial effusion 0.00120413437719261 0.0127730672207532 1.68608782151485 0.32258064516129 9.1 9 1 abnormal retinal photoreceptor layer morphology 0.019482105765624 0.10170354269043 1.68608782151485 0.32258064516129 9.1 9 1 pale kidney 0.019482105765624 0.10170354269043 1.68608782151485 0.32258064516129 9.1 9 1 abnormal podocyte morphology 0.019482105765624 0.10170354269043 1.68608782151485 0.32258064516129 9.1 9 1 increased hemoglobin content 0.00161537058211827 0.01657003844544 1.68323004554618 0.322033898305085 9.1 9 1 abnormal seminal vesicle morphology 0.00216941213411132 0.0201286833185013 1.68006607929515 0.321428571428571 9.1 9 1 abnormal somite shape 0.026699367081037 0.121366472772745 1.68006607929515 0.321428571428571 9.1 9 1 abnormal hormone level 0.026699367081037 0.121366472772745 1.68006607929515 0.321428571428571 9.1 9 1 abnormal brainstem morphology 0.026699367081037 0.121366472772745 1.68006607929515 0.321428571428571 9.1 9 1 prolonged QRS complex duration 0.026699367081037 0.121366472772745 1.68006607929515 0.321428571428571 9.1 9 1 increased neuron apoptosis 0.000262877417358229 0.00396289289391786 1.67776146190243 0.320987654320988 9.1 9 1 increased circulating bilirubin level 0.00291700294066761 0.0254152182658867 1.67654392818552 0.320754716981132 9.1 9 1 abnormal cornea morphology 0.000350865399992438 0.00498730104274966 1.67527956624873 0.320512820512821 9.1 9 1 enlarged spleen 1.59722503378959e-11 2.03748578028288e-09 1.6696953010279 0.319444444444444 9.1 9 1 increased cellular sensitivity to gamma-irradiation 0.00529609498007994 0.0390341815198485 1.66815071703065 0.319148936170213 9.1 9 1 neuron degeneration 0.00529609498007994 0.0390341815198485 1.66815071703065 0.319148936170213 9.1 9 1 reduced female fertility 1.58173137987302e-09 1.35674372670142e-07 1.66719200972201 0.318965517241379 9.1 9 1 abnormal glucose homeostasis 9.03980511646029e-08 4.99700338382111e-06 1.66570654015588 0.318681318681319 9.1 9 1 increased spleen weight 2.32865802400914e-05 0.000533874362647257 1.66519823788546 0.31858407079646 9.1 9 1 decreased body weight 8.67807770529007e-45 4.31734365838181e-41 1.66347953570132 0.318255250403877 9.1 9 1 hyperglycemia 0.000183884431333991 0.00298962433296277 1.66309571485783 0.318181818181818 9.1 9 1 abnormal tail morphology 0.00112084116278362 0.0121170391584625 1.66309571485783 0.318181818181818 9.1 9 1 abnormal circadian rhythm 0.0071538007823617 0.0496375995707803 1.66309571485783 0.318181818181818 9.1 9 1 decreased macrophage cell number 0.0071538007823617 0.0496375995707803 1.66309571485783 0.318181818181818 9.1 9 1 abnormal oogenesis 0.0509042375693 0.199408332210447 1.66309571485783 0.318181818181818 9.1 9 1 aphakia 0.0509042375693 0.199408332210447 1.66309571485783 0.318181818181818 9.1 9 1 abnormal retinal layer morphology 0.0509042375693 0.199408332210447 1.66309571485783 0.318181818181818 9.1 9 1 abnormal temporal bone morphology 0.0509042375693 0.199408332210447 1.66309571485783 0.318181818181818 9.1 9 1 abnormal sperm midpiece morphology 0.0509042375693 0.199408332210447 1.66309571485783 0.318181818181818 9.1 9 1 increased leukocyte cell number 2.11839016201796e-06 7.63553496295185e-05 1.65818016102081 0.317241379310345 9.1 9 1 liver fibrosis 0.00968195700521335 0.0618327806173766 1.65730095626947 0.317073170731707 9.1 9 1 abnormal incisor morphology 0.00201300821966011 0.0191485963533634 1.65517621145374 0.316666666666667 9.1 9 1 abnormal nervous system morphology 0.000435862987350563 0.00600454802966516 1.65407349578988 0.316455696202532 9.1 9 1 delayed sexual maturation 0.0710101118844753 0.236480681301465 1.65059123579875 0.315789473684211 9.1 9 1 decreased tumor incidence 0.0710101118844753 0.236480681301465 1.65059123579875 0.315789473684211 9.1 9 1 increased liver adenoma incidence 0.0710101118844753 0.236480681301465 1.65059123579875 0.315789473684211 9.1 9 1 abnormal blastocyst morphology 0.0710101118844753 0.236480681301465 1.65059123579875 0.315789473684211 9.1 9 1 decreased liver glycogen level 0.0710101118844753 0.236480681301465 1.65059123579875 0.315789473684211 9.1 9 1 thin interventricular septum 0.0710101118844753 0.236480681301465 1.65059123579875 0.315789473684211 9.1 9 1 astrocytosis 0.000776985615884251 0.0092842178766009 1.64682276265765 0.315068493150685 9.1 9 1 decreased percent body fat/body weight 0.000776985615884251 0.0092842178766009 1.64682276265765 0.315068493150685 9.1 9 1 increased cell proliferation 0.00363027493499662 0.0305078003405543 1.64549681840431 0.314814814814815 9.1 9 1 increased tumor incidence 1.52211357814621e-05 0.000380528394536552 1.64393562597698 0.314516129032258 9.1 9 1 decreased total body fat amount 1.86039078074414e-12 2.98562714006519e-10 1.64317840090744 0.31437125748503 9.1 9 1 abnormal erythropoiesis 6.74898369530009e-05 0.00130687305360414 1.64273127753304 0.314285714285714 9.1 9 1 abnormal intestinal goblet cell morphology 0.0178598800436465 0.0941238381537516 1.64273127753304 0.314285714285714 9.1 9 1 decreased triglyceride level 0.0178598800436465 0.0941238381537516 1.64273127753304 0.314285714285714 9.1 9 1 decreased bone mineralization 0.0178598800436465 0.0941238381537516 1.64273127753304 0.314285714285714 9.1 9 1 abnormal dendritic spine morphology 0.00488408540429459 0.0366490571438395 1.63980305778699 0.313725490196078 9.1 9 1 abnormal motor coordination/ balance 0.000119176773881203 0.00210249804985456 1.63669737017755 0.313131313131313 9.1 9 1 cleft palate 1.06631171179218e-05 0.000287296086437397 1.63589131385143 0.312977099236641 9.1 9 1 decreased circulating LDL cholesterol level 0.00185876905002974 0.0182394004416133 1.63339757709251 0.3125 9.1 9 1 abnormal diaphragm morphology 0.0243620352365949 0.120345276109723 1.63339757709251 0.3125 9.1 9 1 abnormal bone marrow cell number 0.100024023869323 0.309657447884184 1.63339757709251 0.3125 9.1 9 1 abnormal mouth morphology 0.100024023869323 0.309657447884184 1.63339757709251 0.3125 9.1 9 1 disorganized yolk sac vascular plexus 0.100024023869323 0.309657447884184 1.63339757709251 0.3125 9.1 9 1 increased intestinal adenocarcinoma incidence 0.100024023869323 0.309657447884184 1.63339757709251 0.3125 9.1 9 1 impaired muscle relaxation 0.100024023869323 0.309657447884184 1.63339757709251 0.3125 9.1 9 1 small epididymis 0.100024023869323 0.309657447884184 1.63339757709251 0.3125 9.1 9 1 abnormal wound healing 0.100024023869323 0.309657447884184 1.63339757709251 0.3125 9.1 9 1 sepsis 0.100024023869323 0.309657447884184 1.63339757709251 0.3125 9.1 9 1 decreased circulating growth hormone level 0.100024023869323 0.309657447884184 1.63339757709251 0.3125 9.1 9 1 blepharitis 0.100024023869323 0.309657447884184 1.63339757709251 0.3125 9.1 9 1 dystonia 0.100024023869323 0.309657447884184 1.63339757709251 0.3125 9.1 9 1 abnormal Langerhans cell physiology 0.100024023869323 0.309657447884184 1.63339757709251 0.3125 9.1 9 1 decreased creatinine clearance 0.100024023869323 0.309657447884184 1.63339757709251 0.3125 9.1 9 1 impaired behavioral response to addictive substance 0.100024023869323 0.309657447884184 1.63339757709251 0.3125 9.1 9 1 decreased liver cholesterol level 0.100024023869323 0.309657447884184 1.63339757709251 0.3125 9.1 9 1 decreased skeletal muscle weight 0.100024023869323 0.309657447884184 1.63339757709251 0.3125 9.1 9 1 increased heart left ventricle size 0.100024023869323 0.309657447884184 1.63339757709251 0.3125 9.1 9 1 embryonic lethality between somite formation and embryo turning, incomplete penetrance 0.100024023869323 0.309657447884184 1.63339757709251 0.3125 9.1 9 1 cyanosis 1.19278953850881e-07 6.31043688479702e-06 1.63339757709251 0.3125 9.1 9 1 increased circulating insulin level 1.28967800203127e-06 5.0921810000838e-05 1.63339757709251 0.3125 9.1 9 1 abnormal retinal pigment epithelium morphology 0.0005383883034593 0.00692114162715767 1.63339757709251 0.3125 9.1 9 1 postnatal growth retardation 4.33847190938373e-21 2.69798721864801e-18 1.63126241686102 0.312091503267974 9.1 9 1 postnatal lethality, incomplete penetrance 1.44930666601325e-19 7.21030066341593e-17 1.62879645715704 0.311619718309859 9.1 9 1 neonatal lethality, incomplete penetrance 9.66059323805937e-10 8.90026877024914e-08 1.62837173839376 0.311538461538462 9.1 9 1 neonatal lethality, complete penetrance 6.02525712058972e-16 1.99837694499559e-13 1.62766635752377 0.31140350877193 9.1 9 1 respiratory failure 2.98463393765729e-06 9.89903589323001e-05 1.62690725559413 0.311258278145695 9.1 9 1 irregular heartbeat 0.00887953005970603 0.057943640217252 1.62613803230543 0.311111111111111 9.1 9 1 albuminuria 0.00887953005970603 0.057943640217252 1.62613803230543 0.311111111111111 9.1 9 1 abnormal cell migration 0.00887953005970603 0.057943640217252 1.62613803230543 0.311111111111111 9.1 9 1 lethality at weaning, complete penetrance 0.00887953005970603 0.057943640217252 1.62613803230543 0.311111111111111 9.1 9 1 abnormal trabecular bone morphology 3.28966070969193e-05 0.000717809738189358 1.62516195905675 0.310924369747899 9.1 9 1 abnormal bone structure 1.46183599012909e-07 7.49756087720846e-06 1.6249343772112 0.310880829015544 9.1 9 1 dermatitis 0.0033387090420538 0.0283932948448165 1.62213276621601 0.310344827586207 9.1 9 1 abnormal microglial cell morphology 0.0333510885858881 0.139664701780129 1.62213276621601 0.310344827586207 9.1 9 1 aphagia 0.0333510885858881 0.139664701780129 1.62213276621601 0.310344827586207 9.1 9 1 abnormal outer ear morphology 0.0333510885858881 0.139664701780129 1.62213276621601 0.310344827586207 9.1 9 1 embryonic growth arrest 1.26256000877483e-08 8.60443293651339e-07 1.62055864417213 0.310043668122271 9.1 9 1 increased monocyte cell number 0.00014641741801252 0.00248609779731156 1.62033039647577 0.31 9.1 9 1 decreased inflammatory response 0.000496590719160768 0.00649922827294669 1.61784140969163 0.30952380952381 9.1 9 1 increased heart weight 9.14293852373097e-06 0.000254112397517104 1.61694609070453 0.309352517985612 9.1 9 1 abnormal embryo development 1.20975908867725e-05 0.00031676586664049 1.61418113500907 0.308823529411765 9.1 9 1 pericardial edema 0.00170944692514699 0.0169075515956387 1.61418113500907 0.308823529411765 9.1 9 1 limb grasping 5.42506713128289e-07 2.38846982107366e-05 1.60826838359878 0.307692307692308 9.1 9 1 decreased trabecular bone volume 0.016260769316527 0.0882203849153193 1.60826838359878 0.307692307692308 9.1 9 1 decreased cardiac muscle contractility 0.000134970771409529 0.00233965013157633 1.60826838359878 0.307692307692308 9.1 9 1 cachexia 0.000134970771409529 0.00233965013157633 1.60826838359878 0.307692307692308 9.1 9 1 eyelids open at birth 0.00602191485898865 0.0438130812965569 1.60826838359878 0.307692307692308 9.1 9 1 thick skin 0.0458552200699886 0.181921626673201 1.60826838359878 0.307692307692308 9.1 9 1 abnormal Mullerian duct morphology 0.0458552200699886 0.181921626673201 1.60826838359878 0.307692307692308 9.1 9 1 increased thymocyte apoptosis 0.0458552200699886 0.181921626673201 1.60826838359878 0.307692307692308 9.1 9 1 postnatal lethality 1.78487123118607e-06 6.57758101863017e-05 1.60584629265963 0.307228915662651 9.1 9 1 premature death 2.18880987981301e-27 2.17786583041395e-24 1.60266466100784 0.306620209059233 9.1 9 1 abnormal epidermis stratum corneum morphology 0.00810238353093076 0.0542521642885337 1.60006293266205 0.306122448979592 9.1 9 1 narrow eye opening 0.0220793396035747 0.111972186062981 1.59709985315712 0.305555555555556 9.1 9 1 preweaning lethality, complete penetrance 2.35720881338924e-23 1.95451897443524e-20 1.59631503750446 0.305405405405405 9.1 9 1 increased circulating HDL cholesterol level 0.000164551455006912 0.00271074002867346 1.59295154185022 0.304761904761905 9.1 9 1 abnormal allantois morphology 0.0109170907704641 0.0674689771218121 1.59078720551618 0.304347826086957 9.1 9 1 abnormal lymphocyte physiology 0.0109170907704641 0.0674689771218121 1.59078720551618 0.304347826086957 9.1 9 1 embryonic lethality between implantation and placentation, complete penetrance 0.0109170907704641 0.0674689771218121 1.59078720551618 0.304347826086957 9.1 9 1 abnormal carpal bone morphology 0.0633841091399233 0.227679381206584 1.59078720551618 0.304347826086957 9.1 9 1 blistering 0.0633841091399233 0.227679381206584 1.59078720551618 0.304347826086957 9.1 9 1 abnormal circulating insulin level 0.0633841091399233 0.227679381206584 1.59078720551618 0.304347826086957 9.1 9 1 hypotension 0.0633841091399233 0.227679381206584 1.59078720551618 0.304347826086957 9.1 9 1 pancreas inflammation 0.0633841091399233 0.227679381206584 1.59078720551618 0.304347826086957 9.1 9 1 abnormal palatal shelf fusion at midline 0.0633841091399233 0.227679381206584 1.59078720551618 0.304347826086957 9.1 9 1 microcephaly 0.00209094056745526 0.0196272251379055 1.59078720551618 0.304347826086957 9.1 9 1 impaired balance 0.000218146629244767 0.00341282855500854 1.58855921223115 0.303921568627451 9.1 9 1 abnormal response to infection 0.00107560659422746 0.0117349622944772 1.58791055595829 0.30379746835443 9.1 9 1 decreased B cell proliferation 0.00107560659422746 0.0117349622944772 1.58791055595829 0.30379746835443 9.1 9 1 increased circulating triglyceride level 1.24870791302371e-05 0.000325252453784972 1.58608537141121 0.303448275862069 9.1 9 1 anophthalmia 0.000556505106207315 0.00709900744456768 1.58568034450329 0.303370786516854 9.1 9 1 belly spot 0.0300621266027043 0.133415771497283 1.58390068081698 0.303030303030303 9.1 9 1 cardiovascular system phenotype 0.0300621266027043 0.133415771497283 1.58390068081698 0.303030303030303 9.1 9 1 abnormal vertebrae morphology 0.000150885208966747 0.00252745425794467 1.58244756092632 0.302752293577982 9.1 9 1 abnormal renal glomerulus morphology 0.000150885208966747 0.00252745425794467 1.58244756092632 0.302752293577982 9.1 9 1 increased circulating creatinine level 0.000739307259656129 0.0089490355639641 1.58021719086159 0.302325581395349 9.1 9 1 abnormal organ of Corti morphology 0.0147330386572851 0.0832918946818108 1.58021719086159 0.302325581395349 9.1 9 1 abnormal left-right axis patterning 0.0147330386572851 0.0832918946818108 1.58021719086159 0.302325581395349 9.1 9 1 impaired macrophage phagocytosis 0.0147330386572851 0.0832918946818108 1.58021719086159 0.302325581395349 9.1 9 1 abnormal blood circulation 0.0147330386572851 0.0832918946818108 1.58021719086159 0.302325581395349 9.1 9 1 reduced fertility 2.17655965806834e-05 0.000508374849713145 1.57934269324628 0.302158273381295 9.1 9 1 abnormal mesoderm development 0.00736457947231665 0.0509579734002438 1.57792369711578 0.30188679245283 9.1 9 1 abnormal liver morphology 1.68653002812483e-06 6.31866864678725e-05 1.57682179509266 0.301675977653631 9.1 9 1 abnormal hair follicle morphology 0.00373040768634929 0.0308218994821445 1.57635829662261 0.301587301587302 9.1 9 1 seminiferous tubule degeneration 0.00190758439681921 0.0186336566812502 1.57522177297689 0.301369863013699 9.1 9 1 abnormal neural tube closure 0.00098241941534959 0.0111587593410142 1.57435911045061 0.301204819277108 9.1 9 1 postnatal lethality, complete penetrance 3.71532303663353e-12 5.43639179625053e-10 1.57076989797083 0.300518134715026 9.1 9 1 decreased insulin secretion 0.000674881141466372 0.00822924921273334 1.56806167400881 0.3 9.1 9 1 increased body length 0.00989161418187617 0.0628490173114099 1.56806167400881 0.3 9.1 9 1 abnormal axon extension 0.00989161418187617 0.0628490173114099 1.56806167400881 0.3 9.1 9 1 decreased respiratory quotient 0.00989161418187617 0.0628490173114099 1.56806167400881 0.3 9.1 9 1 abnormal hair cycle 0.0410628036542986 0.169392577263794 1.56806167400881 0.3 9.1 9 1 abnormal response to new environment 0.0410628036542986 0.169392577263794 1.56806167400881 0.3 9.1 9 1 abnormal pain threshold 0.0410628036542986 0.169392577263794 1.56806167400881 0.3 9.1 9 1 abnormal spleen marginal zone morphology 0.0410628036542986 0.169392577263794 1.56806167400881 0.3 9.1 9 1 abnormal brain vasculature morphology 0.0410628036542986 0.169392577263794 1.56806167400881 0.3 9.1 9 1 impaired ovarian folliculogenesis 0.0199185757196472 0.103764308068319 1.56806167400881 0.3 9.1 9 1 abnormal pancreatic beta cell morphology 0.0199185757196472 0.103764308068319 1.56806167400881 0.3 9.1 9 1 increased urine glucose level 0.0882026865235091 0.277902701364445 1.56806167400881 0.3 9.1 9 1 brain inflammation 0.0882026865235091 0.277902701364445 1.56806167400881 0.3 9.1 9 1 decreased myocardial infarction size 0.0882026865235091 0.277902701364445 1.56806167400881 0.3 9.1 9 1 abnormal incus morphology 0.0882026865235091 0.277902701364445 1.56806167400881 0.3 9.1 9 1 abnormal neuron proliferation 0.0882026865235091 0.277902701364445 1.56806167400881 0.3 9.1 9 1 decreased leukocyte cell number 3.47032358385616e-05 0.000753924010029887 1.56424643879224 0.299270072992701 9.1 9 1 infertility 0.000241644508071029 0.00373348269457569 1.56317674667545 0.299065420560748 9.1 9 1 abnormal spleen morphology 3.5268570247739e-06 0.00011468048168791 1.56205377487468 0.298850574712644 9.1 9 1 decreased compact bone thickness 0.00338908393854017 0.0287725129594494 1.56026037214807 0.298507462686567 9.1 9 1 hepatic necrosis 0.013301755651233 0.078875130351471 1.55694066922861 0.297872340425532 9.1 9 1 increased brown adipose tissue amount 0.0269843234211078 0.121366472772745 1.55393499226098 0.297297297297297 9.1 9 1 abnormal vocalization 0.0269843234211078 0.121366472772745 1.55393499226098 0.297297297297297 9.1 9 1 abnormal pancreatic beta cell physiology 0.0269843234211078 0.121366472772745 1.55393499226098 0.297297297297297 9.1 9 1 decreased body size 1.23203434235994e-22 8.75624407605814e-20 1.55234175747739 0.296992481203008 9.1 9 1 neurodegeneration 0.00893691822487245 0.057943640217252 1.54870288790994 0.296296296296296 9.1 9 1 abnormal palate morphology 0.0563037200390771 0.211417716286054 1.54870288790994 0.296296296296296 9.1 9 1 decreased bone ossification 0.0563037200390771 0.211417716286054 1.54870288790994 0.296296296296296 9.1 9 1 short femur 0.00107940794615274 0.0117506663722317 1.54430316379656 0.295454545454545 9.1 9 1 osteoporosis 0.0179114287338659 0.0941959386374028 1.54430316379656 0.295454545454545 9.1 9 1 decreased circulating alanine transaminase level 0.00408893269412065 0.0319813337923083 1.5373153666753 0.294117647058824 9.1 9 1 abnormal cued conditioning behavior 0.0119780845058685 0.0732172464670156 1.5373153666753 0.294117647058824 9.1 9 1 impaired hematopoiesis 0.0119780845058685 0.0732172464670156 1.5373153666753 0.294117647058824 9.1 9 1 abnormal thrombosis 0.0119780845058685 0.0732172464670156 1.5373153666753 0.294117647058824 9.1 9 1 abnormal endoderm development 0.0366421614793641 0.152547910761369 1.5373153666753 0.294117647058824 9.1 9 1 decreased regulatory T cell number 0.0366421614793641 0.152547910761369 1.5373153666753 0.294117647058824 9.1 9 1 increased susceptibility to weight gain 0.0366421614793641 0.152547910761369 1.5373153666753 0.294117647058824 9.1 9 1 increased susceptibility to viral infection induced morbidity/mortality 0.0366421614793641 0.152547910761369 1.5373153666753 0.294117647058824 9.1 9 1 abnormal urinary bladder morphology 0.123810056927925 0.342197240675792 1.5373153666753 0.294117647058824 9.1 9 1 hyperlipidemia 0.123810056927925 0.342197240675792 1.5373153666753 0.294117647058824 9.1 9 1 abnormal duodenum morphology 0.123810056927925 0.342197240675792 1.5373153666753 0.294117647058824 9.1 9 1 abnormal tarsal bone morphology 0.123810056927925 0.342197240675792 1.5373153666753 0.294117647058824 9.1 9 1 pancytopenia 0.123810056927925 0.342197240675792 1.5373153666753 0.294117647058824 9.1 9 1 increased brain size 0.123810056927925 0.342197240675792 1.5373153666753 0.294117647058824 9.1 9 1 enhanced behavioral response to cocaine 0.123810056927925 0.342197240675792 1.5373153666753 0.294117647058824 9.1 9 1 common atrium 0.123810056927925 0.342197240675792 1.5373153666753 0.294117647058824 9.1 9 1 abnormal ductus venosus valve morphology 0.123810056927925 0.342197240675792 1.5373153666753 0.294117647058824 9.1 9 1 decreased body fat mass 0.123810056927925 0.342197240675792 1.5373153666753 0.294117647058824 9.1 9 1 curly tail 0.0160694412496301 0.0873720985977156 1.52450440528634 0.291666666666667 9.1 9 1 curly vibrissae 0.077558728893806 0.256381844682183 1.52450440528634 0.291666666666667 9.1 9 1 hemolytic anemia 0.077558728893806 0.256381844682183 1.52450440528634 0.291666666666667 9.1 9 1 abnormal primitive streak formation 0.077558728893806 0.256381844682183 1.52450440528634 0.291666666666667 9.1 9 1 abnormal cardiac muscle contractility 0.077558728893806 0.256381844682183 1.52450440528634 0.291666666666667 9.1 9 1 abnormal tumor morphology 0.077558728893806 0.256381844682183 1.52450440528634 0.291666666666667 9.1 9 1 increased body temperature 0.077558728893806 0.256381844682183 1.52450440528634 0.291666666666667 9.1 9 1 abnormal placenta labyrinth morphology 0.00251198471544259 0.0228885054200126 1.52174761612669 0.291139240506329 9.1 9 1 decreased food intake 0.00251198471544259 0.0228885054200126 1.52174761612669 0.291139240506329 9.1 9 1 abnormal learning/memory/conditioning 0.0107648463891505 0.0668603130911658 1.5205446535843 0.290909090909091 9.1 9 1 increased lung adenoma incidence 0.0498912709723928 0.196212705998145 1.51747903936337 0.290322580645161 9.1 9 1 decreased double-negative T cell number 0.0498912709723928 0.196212705998145 1.51747903936337 0.290322580645161 9.1 9 1 abnormal mitochondrial ATP synthesis coupled electron transport 0.0498912709723928 0.196212705998145 1.51747903936337 0.290322580645161 9.1 9 1 abnormal liver physiology 0.000802370799532655 0.00948169769043933 1.51579295154185 0.29 9.1 9 1 increased lymphocyte cell number 0.00490443968459631 0.036746366612751 1.51503543382494 0.289855072463768 9.1 9 1 persistence of hyaloid vascular system 0.0326275136049609 0.136980489607325 1.51304196614885 0.289473684210526 9.1 9 1 decreased total retina thickness 0.0326275136049609 0.136980489607325 1.51304196614885 0.289473684210526 9.1 9 1 short tail 0.00226680276709811 0.0209616055135931 1.51138474603259 0.289156626506024 9.1 9 1 abnormal ovarian follicle morphology 0.0215806375702434 0.109666672024475 1.50998531571219 0.288888888888889 9.1 9 1 abnormal metabolism 0.0215806375702434 0.109666672024475 1.50998531571219 0.288888888888889 9.1 9 1 no abnormal phenotype detected 1.70302552586526e-43 4.23627599558984e-40 1.50931584760502 0.288760806916427 9.1 9 1 abnormal myocardial fiber morphology 0.00105831537213299 0.01159717836203 1.50878786502566 0.288659793814433 9.1 9 1 abnormal behavior 6.21621513876789e-08 3.63831415474944e-06 1.50413589832979 0.287769784172662 9.1 9 1 short limbs 0.00204335035643016 0.019326365063194 1.50197478353334 0.28735632183908 9.1 9 1 decreased circulating glucose level 7.35563988488409e-08 4.20624234796533e-06 1.49874473023542 0.28673835125448 9.1 9 1 spleen hypoplasia 0.000861476387706623 0.0100136566094403 1.49339207048458 0.285714285714286 9.1 9 1 domed cranium 0.00584940308028933 0.0427324233839052 1.49339207048458 0.285714285714286 9.1 9 1 abnormal pancreas morphology 0.0290146498784449 0.129112596731005 1.49339207048458 0.285714285714286 9.1 9 1 abnormal reproductive system morphology 0.0290146498784449 0.129112596731005 1.49339207048458 0.285714285714286 9.1 9 1 abnormal spleen white pulp morphology 0.0290146498784449 0.129112596731005 1.49339207048458 0.285714285714286 9.1 9 1 spina bifida 0.0290146498784449 0.129112596731005 1.49339207048458 0.285714285714286 9.1 9 1 increased carcinoma incidence 0.0441550740536511 0.176628368807222 1.49339207048458 0.285714285714286 9.1 9 1 abnormal hippocampus pyramidal cell morphology 0.0441550740536511 0.176628368807222 1.49339207048458 0.285714285714286 9.1 9 1 shortened head 0.0681454612222931 0.231273374881832 1.49339207048458 0.285714285714286 9.1 9 1 abnormal ovulation 0.0681454612222931 0.231273374881832 1.49339207048458 0.285714285714286 9.1 9 1 failure of blastocyst to hatch from the zona pellucida 0.0681454612222931 0.231273374881832 1.49339207048458 0.285714285714286 9.1 9 1 hypoxia 0.0681454612222931 0.231273374881832 1.49339207048458 0.285714285714286 9.1 9 1 abnormal salivary gland morphology 0.107446632542708 0.331604836786582 1.49339207048458 0.285714285714286 9.1 9 1 liver degeneration 0.107446632542708 0.331604836786582 1.49339207048458 0.285714285714286 9.1 9 1 abnormal erythrocyte physiology 0.107446632542708 0.331604836786582 1.49339207048458 0.285714285714286 9.1 9 1 complete atrioventricular septal defect 0.107446632542708 0.331604836786582 1.49339207048458 0.285714285714286 9.1 9 1 embryonic lethality at implantation, complete penetrance 0.107446632542708 0.331604836786582 1.49339207048458 0.285714285714286 9.1 9 1 increased sarcoma incidence 0.0192562643371098 0.100948277215091 1.49339207048458 0.285714285714286 9.1 9 1 abnormal respiratory system physiology 0.0192562643371098 0.100948277215091 1.49339207048458 0.285714285714286 9.1 9 1 increased bone mineral content 0.00077635994720879 0.0092842178766009 1.48654164814291 0.284403669724771 9.1 9 1 increased inflammatory response 0.00165600372240294 0.0167686369586694 1.48553211221887 0.284210526315789 9.1 9 1 increased liver weight 0.00242586718590534 0.0223494245368131 1.48490688826592 0.284090909090909 9.1 9 1 small seminiferous tubules 0.00524647336326187 0.0387833655010814 1.48330158352185 0.283783783783784 9.1 9 1 decreased white adipose tissue amount 0.00775356714312455 0.0519865182439955 1.48224735354067 0.283582089552239 9.1 9 1 abnormal pancreatic islet morphology 0.017167024877768 0.0911482911066126 1.47930346604605 0.283018867924528 9.1 9 1 small testis 2.04613845851533e-07 9.97994003050369e-06 1.47715954797931 0.282608695652174 9.1 9 1 abnormal circulating hormone level 0.0390573060039884 0.161925081141535 1.47424601829888 0.282051282051282 9.1 9 1 reduced male fertility 2.62679432940244e-06 8.95089163614872e-05 1.47365561140329 0.281938325991189 9.1 9 1 atelectasis 0.00693845506708958 0.0482780614807981 1.472358379351 0.28169014084507 9.1 9 1 corneal opacity 0.00693845506708958 0.0482780614807981 1.472358379351 0.28169014084507 9.1 9 1 abnormal lumbar vertebrae morphology 0.0598809719124877 0.221391496339705 1.47005781938326 0.28125 9.1 9 1 abnormal depression-related behavior 0.0598809719124877 0.221391496339705 1.47005781938326 0.28125 9.1 9 1 abnormal spongiotrophoblast layer morphology 0.0598809719124877 0.221391496339705 1.47005781938326 0.28125 9.1 9 1 microphthalmia 0.000114849649302729 0.00207748865834987 1.46899023926751 0.281045751633987 9.1 9 1 abnormal bone mineralization 0.000566208885858096 0.00720432022287475 1.46870790403029 0.28099173553719 9.1 9 1 improved glucose tolerance 1.47851642026643e-05 0.000371495918728559 1.46672435494021 0.280612244897959 9.1 9 1 abnormal motor capabilities/coordination/movement 0.000350357527959759 0.00498730104274966 1.46510812975571 0.28030303030303 9.1 9 1 weight loss 4.45399184767064e-05 0.000923275393423393 1.46352422907489 0.28 9.1 9 1 decreased heart rate 0.0017563096787551 0.0173022587164488 1.46352422907489 0.28 9.1 9 1 spontaneous skin ulceration 0.0934248253962938 0.293057065792284 1.46352422907489 0.28 9.1 9 1 abnormal nest building behavior 0.0934248253962938 0.293057065792284 1.46352422907489 0.28 9.1 9 1 abnormal primitive streak morphology 0.0934248253962938 0.293057065792284 1.46352422907489 0.28 9.1 9 1 increased cellular sensitivity to ionizing radiation 0.0934248253962938 0.293057065792284 1.46352422907489 0.28 9.1 9 1 decreased placenta weight 0.0934248253962938 0.293057065792284 1.46352422907489 0.28 9.1 9 1 abnormal vertebrae development 0.0934248253962938 0.293057065792284 1.46352422907489 0.28 9.1 9 1 lung inflammation 0.000315129684616822 0.00454794682266334 1.46044959834154 0.279411764705882 9.1 9 1 abnormal double-strand DNA break repair 0.0345430155124423 0.144413027037311 1.45866202233378 0.27906976744186 9.1 9 1 increased double-negative T cell number 0.0136219473334153 0.0806776047425489 1.45666931465299 0.278688524590164 9.1 9 1 increased circulating cholesterol level 5.22055432481851e-05 0.00105150841157782 1.4552087505006 0.278409090909091 9.1 9 1 axon degeneration 0.0203324505134971 0.105588665244936 1.45190895741557 0.277777777777778 9.1 9 1 abnormal neuromuscular synapse morphology 0.00818700791291198 0.0543071524889828 1.45190895741557 0.277777777777778 9.1 9 1 abnormal limb bone morphology 0.0526457411498343 0.205906102374549 1.45190895741557 0.277777777777778 9.1 9 1 abnormal megakaryocyte differentiation 0.149921697058191 0.371434909800017 1.45190895741557 0.277777777777778 9.1 9 1 underdeveloped hair follicles 0.149921697058191 0.371434909800017 1.45190895741557 0.277777777777778 9.1 9 1 abnormal stomach glandular epithelium morphology 0.149921697058191 0.371434909800017 1.45190895741557 0.277777777777778 9.1 9 1 abnormal white adipose tissue morphology 0.149921697058191 0.371434909800017 1.45190895741557 0.277777777777778 9.1 9 1 acidosis 0.149921697058191 0.371434909800017 1.45190895741557 0.277777777777778 9.1 9 1 decreased cellular sensitivity to gamma-irradiation 0.149921697058191 0.371434909800017 1.45190895741557 0.277777777777778 9.1 9 1 increased circulating renin level 0.149921697058191 0.371434909800017 1.45190895741557 0.277777777777778 9.1 9 1 abnormal body wall morphology 0.149921697058191 0.371434909800017 1.45190895741557 0.277777777777778 9.1 9 1 increased circulating glycerol level 0.149921697058191 0.371434909800017 1.45190895741557 0.277777777777778 9.1 9 1 abnormal eye anterior chamber morphology 0.149921697058191 0.371434909800017 1.45190895741557 0.277777777777778 9.1 9 1 darkened coat color 0.149921697058191 0.371434909800017 1.45190895741557 0.277777777777778 9.1 9 1 jerky movement 0.149921697058191 0.371434909800017 1.45190895741557 0.277777777777778 9.1 9 1 increased gastrointestinal tumor incidence 0.149921697058191 0.371434909800017 1.45190895741557 0.277777777777778 9.1 9 1 primary atelectasis 0.149921697058191 0.371434909800017 1.45190895741557 0.277777777777778 9.1 9 1 increased effector memory CD4-positive, alpha-beta T cell number 0.149921697058191 0.371434909800017 1.45190895741557 0.277777777777778 9.1 9 1 increased effector memory CD8-positive, alpha-beta T cell number 0.149921697058191 0.371434909800017 1.45190895741557 0.277777777777778 9.1 9 1 impaired leukocyte tethering or rolling 0.149921697058191 0.371434909800017 1.45190895741557 0.277777777777778 9.1 9 1 abnormal spermatogenesis 4.22743610162768e-05 0.000883676243932677 1.4487526335951 0.277173913043478 9.1 9 1 abnormal T-helper 1 physiology 0.0305530684418305 0.135099433349204 1.44573062142656 0.276595744680851 9.1 9 1 abnormal humoral immune response 0.00184799131204355 0.0181694797972661 1.44361233480176 0.276190476190476 9.1 9 1 increased total body fat amount 0.000481394624488199 0.00643800606674406 1.44324084423697 0.276119402985075 9.1 9 1 abnormal middle ear morphology 0.0814004603218761 0.266075749081034 1.44189579219201 0.275862068965517 9.1 9 1 abnormal circulating glucose level 0.0814004603218761 0.266075749081034 1.44189579219201 0.275862068965517 9.1 9 1 enlarged epididymis 0.0814004603218761 0.266075749081034 1.44189579219201 0.275862068965517 9.1 9 1 distended abdomen 0.0270299601672768 0.121366472772745 1.43482767556362 0.274509803921569 9.1 9 1 increased lung adenocarcinoma incidence 0.0270299601672768 0.121366472772745 1.43482767556362 0.274509803921569 9.1 9 1 abnormal cervical vertebrae morphology 0.0270299601672768 0.121366472772745 1.43482767556362 0.274509803921569 9.1 9 1 decreased litter size 9.24446830619427e-07 3.80092808457161e-05 1.43227460140781 0.274021352313167 9.1 9 1 abnormal fertility/fecundity 0.00961118638928485 0.0614597073093729 1.43201979361535 0.273972602739726 9.1 9 1 increased food intake 0.00580994544215493 0.0425065861392952 1.43116740088106 0.273809523809524 9.1 9 1 decreased birth weight 0.00353391573312369 0.0297986962242209 1.43051240435891 0.273684210526316 9.1 9 1 increased sensitivity to xenobiotic induced morbidity/mortality 0.00193106242793236 0.0187302039652156 1.42551061273528 0.272727272727273 9.1 9 1 increased circulating calcium level 0.0239203020601272 0.118411445521525 1.42551061273528 0.272727272727273 9.1 9 1 abnormal rostral-caudal axis patterning 0.0239203020601272 0.118411445521525 1.42551061273528 0.272727272727273 9.1 9 1 obese 0.00855525109531679 0.056523737316336 1.42551061273528 0.272727272727273 9.1 9 1 abnormal skin morphology 0.0142333149297675 0.082723418096667 1.42551061273528 0.272727272727273 9.1 9 1 decreased blood urea nitrogen level 0.0407798605544084 0.168925733770343 1.42551061273528 0.272727272727273 9.1 9 1 abnormal ovarian folliculogenesis 0.0710630389036564 0.236480681301465 1.42551061273528 0.272727272727273 9.1 9 1 decreased systemic arterial blood pressure 0.0710630389036564 0.236480681301465 1.42551061273528 0.272727272727273 9.1 9 1 abnormal enterocyte morphology 0.128650030657736 0.354001052279997 1.42551061273528 0.272727272727273 9.1 9 1 increased coping response 0.128650030657736 0.354001052279997 1.42551061273528 0.272727272727273 9.1 9 1 cleft upper lip 0.128650030657736 0.354001052279997 1.42551061273528 0.272727272727273 9.1 9 1 increased mammary gland tumor incidence 0.128650030657736 0.354001052279997 1.42551061273528 0.272727272727273 9.1 9 1 increased adenoma incidence 0.128650030657736 0.354001052279997 1.42551061273528 0.272727272727273 9.1 9 1 syndactyly 0.0211757130947595 0.107939726072161 1.41745688045994 0.271186440677966 9.1 9 1 oligodactyly 0.0359327013989335 0.150096716590843 1.41561123348018 0.270833333333333 9.1 9 1 increased insulin secretion 0.0621499699382516 0.224217621785933 1.41266817478271 0.27027027027027 9.1 9 1 abnormal hair follicle development 0.0621499699382516 0.224217621785933 1.41266817478271 0.27027027027027 9.1 9 1 increased circulating aspartate transaminase level 0.0187529423950445 0.0985173056128263 1.41042584434655 0.26984126984127 9.1 9 1 decreased rib number 0.00603527463064504 0.0438328339962906 1.40949363955848 0.269662921348315 9.1 9 1 abnormal testis morphology 0.00200565777121907 0.0191152249268485 1.40898295345719 0.269565217391304 9.1 9 1 abnormal nervous system physiology 0.00200565777121907 0.0191152249268485 1.40898295345719 0.269565217391304 9.1 9 1 increased circulating glucose level 0.000679324752084201 0.00826318005285794 1.40866060549255 0.269503546099291 9.1 9 1 increased circulating alanine transaminase level 0.00997474605893921 0.0632963796469676 1.40723483564893 0.269230769230769 9.1 9 1 abnormal brain wave pattern 0.0316857752218748 0.135099433349204 1.40723483564893 0.269230769230769 9.1 9 1 decreased body temperature 0.0316857752218748 0.135099433349204 1.40723483564893 0.269230769230769 9.1 9 1 abnormal kidney cortex morphology 0.11095046946388 0.340947088864509 1.40723483564893 0.269230769230769 9.1 9 1 small seminal vesicle 0.11095046946388 0.340947088864509 1.40723483564893 0.269230769230769 9.1 9 1 no spontaneous movement 0.11095046946388 0.340947088864509 1.40723483564893 0.269230769230769 9.1 9 1 abnormal ocular fundus morphology 0.11095046946388 0.340947088864509 1.40723483564893 0.269230769230769 9.1 9 1 decreased Peyer's patch number 0.11095046946388 0.340947088864509 1.40723483564893 0.269230769230769 9.1 9 1 decreased anxiety-related response 0.00159871006553226 0.0164330218512871 1.40233157838186 0.268292682926829 9.1 9 1 abnormal developmental patterning 0.00886332793820617 0.057943640217252 1.40233157838186 0.268292682926829 9.1 9 1 Leydig cell hyperplasia 0.0544430400828821 0.211417716286054 1.40233157838186 0.268292682926829 9.1 9 1 thick ventricular wall 0.0544430400828821 0.211417716286054 1.40233157838186 0.268292682926829 9.1 9 1 abnormal neuron differentiation 0.00260495358612294 0.0236489855674482 1.4000550660793 0.267857142857143 9.1 9 1 decreased circulating cholesterol level 0.000149672762619607 0.00252745425794467 1.39954502780386 0.26775956284153 9.1 9 1 epidermal hyperplasia 0.0246915842770974 0.120345276109723 1.39383259911894 0.266666666666667 9.1 9 1 decreased osteoclast cell number 0.0477613961850138 0.189182281863411 1.39383259911894 0.266666666666667 9.1 9 1 spleen hyperplasia 0.0130539828670104 0.078385203512561 1.39383259911894 0.266666666666667 9.1 9 1 increased anxiety-related response 0.00101593489724206 0.0112604541042488 1.39132570595506 0.266187050359712 9.1 9 1 decreased eosinophil cell number 0.021818561461428 0.110762595174086 1.38838794052863 0.265625 9.1 9 1 increased circulating LDL cholesterol level 0.0419547481157031 0.170974781885633 1.38672120830711 0.26530612244898 9.1 9 1 increased T cell derived lymphoma incidence 0.0419547481157031 0.170974781885633 1.38672120830711 0.26530612244898 9.1 9 1 decreased circulating creatinine level 0.0419547481157031 0.170974781885633 1.38672120830711 0.26530612244898 9.1 9 1 decreased susceptibility to injury 0.0192917001775678 0.101027587772 1.38358383000777 0.264705882352941 9.1 9 1 impaired synaptic plasticity 0.0834545547764017 0.271541144547154 1.38358383000777 0.264705882352941 9.1 9 1 abnormal spleen red pulp morphology 0.0834545547764017 0.271541144547154 1.38358383000777 0.264705882352941 9.1 9 1 abnormal brown adipose tissue morphology 0.0834545547764017 0.271541144547154 1.38358383000777 0.264705882352941 9.1 9 1 abnormal nervous system development 0.0834545547764017 0.271541144547154 1.38358383000777 0.264705882352941 9.1 9 1 abnormal placenta development 0.0368976343197593 0.153483052458865 1.38068323497631 0.264150943396226 9.1 9 1 abnormal forebrain development 0.0170673338996821 0.0907157971697846 1.37931350954479 0.263888888888889 9.1 9 1 increased body weight 5.66734411227602e-05 0.00112330824536148 1.37672081497797 0.263392857142857 9.1 9 1 impaired righting response 0.00718764458300156 0.0498029690813827 1.37549269649896 0.263157894736842 9.1 9 1 abnormal blood homeostasis 0.00347014161261755 0.0294104847065968 1.37549269649896 0.263157894736842 9.1 9 1 decreased susceptibility to induced arthritis 0.0324847899440985 0.136611859655021 1.37549269649896 0.263157894736842 9.1 9 1 abnormal circulating amino acid level 0.0324847899440985 0.136611859655021 1.37549269649896 0.263157894736842 9.1 9 1 abnormal triglyceride level 0.178104406048804 0.40057387888463 1.37549269649896 0.263157894736842 9.1 9 1 short vibrissae 0.178104406048804 0.40057387888463 1.37549269649896 0.263157894736842 9.1 9 1 abnormal neurotransmitter level 0.178104406048804 0.40057387888463 1.37549269649896 0.263157894736842 9.1 9 1 abnormal metatarsal bone morphology 0.178104406048804 0.40057387888463 1.37549269649896 0.263157894736842 9.1 9 1 osteoarthritis 0.178104406048804 0.40057387888463 1.37549269649896 0.263157894736842 9.1 9 1 eyelids fail to open 0.178104406048804 0.40057387888463 1.37549269649896 0.263157894736842 9.1 9 1 Leydig cell hypoplasia 0.178104406048804 0.40057387888463 1.37549269649896 0.263157894736842 9.1 9 1 decreased circulating magnesium level 0.178104406048804 0.40057387888463 1.37549269649896 0.263157894736842 9.1 9 1 increased or absent threshold for auditory brainstem response 5.71328652401492e-06 0.00016818698495251 1.3745407984391 0.262975778546713 9.1 9 1 decreased B cell number 0.000130149920742217 0.00228797122152837 1.37015097728925 0.262135922330097 9.1 9 1 abnormal retina morphology 0.000116335104070048 0.00208175563666252 1.36894273127753 0.261904761904762 9.1 9 1 abnormal optic nerve morphology 0.0634660172521985 0.227809116760236 1.36894273127753 0.261904761904762 9.1 9 1 abnormal innervation pattern to muscle 0.151685061781669 0.371434909800017 1.36353189044244 0.260869565217391 9.1 9 1 conjunctivitis 0.151685061781669 0.371434909800017 1.36353189044244 0.260869565217391 9.1 9 1 abnormal cochlear ganglion morphology 0.151685061781669 0.371434909800017 1.36353189044244 0.260869565217391 9.1 9 1 abnormal corneal stroma morphology 0.151685061781669 0.371434909800017 1.36353189044244 0.260869565217391 9.1 9 1 abnormal lens development 0.151685061781669 0.371434909800017 1.36353189044244 0.260869565217391 9.1 9 1 abnormal hindlimb morphology 0.0486503367644487 0.19224418221059 1.35898678414097 0.26 9.1 9 1 kidney inflammation 0.0486503367644487 0.19224418221059 1.35898678414097 0.26 9.1 9 1 abnormal circulating protein level 0.0486503367644487 0.19224418221059 1.35898678414097 0.26 9.1 9 1 polyuria 0.0174066965694747 0.0923222979031309 1.35762915498598 0.25974025974026 9.1 9 1 abnormal trigeminal ganglion morphology 0.130076831762561 0.356350351331906 1.35511502692119 0.259259259259259 9.1 9 1 abnormal brain commissure morphology 0.130076831762561 0.356350351331906 1.35511502692119 0.259259259259259 9.1 9 1 decreased circulating fructosamine level 0.130076831762561 0.356350351331906 1.35511502692119 0.259259259259259 9.1 9 1 abnormal object recognition memory 0.112130413244936 0.340947088864509 1.34887025721188 0.258064516129032 9.1 9 1 impaired coordination 2.59180594310587e-06 8.89257556341497e-05 1.34448447964147 0.257225433526012 9.1 9 1 increased red blood cell distribution width 0.0970582211804307 0.303879578585678 1.34405286343612 0.257142857142857 9.1 9 1 abnormal lens fiber morphology 0.0842924623909327 0.273909209924814 1.34022365299898 0.256410256410256 9.1 9 1 cataract 0.00463494516678647 0.0352043545110881 1.33911603014527 0.256198347107438 9.1 9 1 abnormal T-helper 2 physiology 0.0491064743174518 0.193738865764729 1.33047657188626 0.254545454545455 9.1 9 1 abnormal colon morphology 0.0430908571385414 0.172745378133959 1.3288658254312 0.254237288135593 9.1 9 1 increased B cell proliferation 0.0430908571385414 0.172745378133959 1.3288658254312 0.254237288135593 9.1 9 1 skin lesions 0.0378628332652231 0.15710391617555 1.32745961820852 0.253968253968254 9.1 9 1 gliosis 0.0378628332652231 0.15710391617555 1.32745961820852 0.253968253968254 9.1 9 1 abnormal CD4-positive, alpha-beta T cell physiology 0.0293338179515477 0.130416214753307 1.3251225414159 0.253521126760563 9.1 9 1 hunched posture 0.0228141190587983 0.11506413970609 1.32325879663191 0.253164556962025 9.1 9 1 abnormal lipid level 0.0201444706433614 0.104831319509125 1.32246165277851 0.253012048192771 9.1 9 1 small ovary 0.0157391267384328 0.0864262202248379 1.32107760081328 0.252747252747253 9.1 9 1 alopecia 0.0139252934849626 0.0823761416024839 1.320472988639 0.252631578947368 9.1 9 1 abnormal neuron morphology 0.0123274805730267 0.0750663596705116 1.31991723401415 0.252525252525253 9.1 9 1 abnormal hepatocyte morphology 0.00857806868007139 0.0565243598455035 1.31849029646386 0.252252252252252 9.1 9 1 decreased IgG level 0.00857806868007139 0.0565243598455035 1.31849029646386 0.252252252252252 9.1 9 1 hyperactivity 5.00157555427843e-06 0.000156495838883869 1.31024021278364 0.250673854447439 9.1 9 1 decreased circulating HDL cholesterol level 0.00602374826268239 0.0438130812965569 1.30671806167401 0.25 9.1 9 1 decreased lymphocyte cell number 0.00602374826268239 0.0438130812965569 1.30671806167401 0.25 9.1 9 1 enlarged liver 0.0139907169473815 0.0826648655738989 1.30671806167401 0.25 9.1 9 1 abnormal suckling behavior 0.0202305625838451 0.105169330046635 1.30671806167401 0.25 9.1 9 1 abnormal eye development 0.0561548942898654 0.211417716286054 1.30671806167401 0.25 9.1 9 1 absent corpus luteum 0.0641671167791043 0.229828226044668 1.30671806167401 0.25 9.1 9 1 abnormal skin condition 0.0641671167791043 0.229828226044668 1.30671806167401 0.25 9.1 9 1 polydipsia 0.129546893689085 0.355485822450744 1.30671806167401 0.25 9.1 9 1 abnormal lymphatic vessel morphology 0.129546893689085 0.355485822450744 1.30671806167401 0.25 9.1 9 1 neonatal lethality 0.129546893689085 0.355485822450744 1.30671806167401 0.25 9.1 9 1 increased fatty acid level 0.129546893689085 0.355485822450744 1.30671806167401 0.25 9.1 9 1 abnormal respiration 0.15072062194265 0.371434909800017 1.30671806167401 0.25 9.1 9 1 straub tail 0.15072062194265 0.371434909800017 1.30671806167401 0.25 9.1 9 1 waved hair 0.208071645890569 0.445611897677823 1.30671806167401 0.25 9.1 9 1 anencephaly 0.208071645890569 0.445611897677823 1.30671806167401 0.25 9.1 9 1 abnormal dopamine level 0.208071645890569 0.445611897677823 1.30671806167401 0.25 9.1 9 1 abnormal hair texture 0.208071645890569 0.445611897677823 1.30671806167401 0.25 9.1 9 1 absent placental labyrinth 0.208071645890569 0.445611897677823 1.30671806167401 0.25 9.1 9 1 spleen atrophy 0.208071645890569 0.445611897677823 1.30671806167401 0.25 9.1 9 1 abnormal response to tactile stimuli 0.208071645890569 0.445611897677823 1.30671806167401 0.25 9.1 9 1 abnormal induced retinal neovascularization 0.208071645890569 0.445611897677823 1.30671806167401 0.25 9.1 9 1 abnormal sperm mitochondrial sheath morphology 0.208071645890569 0.445611897677823 1.30671806167401 0.25 9.1 9 1 nuclear cataracts 0.208071645890569 0.445611897677823 1.30671806167401 0.25 9.1 9 1 abnormal heart electrocardiography waveform feature 0.208071645890569 0.445611897677823 1.30671806167401 0.25 9.1 9 1 abnormal heart left ventricle morphology 0.0334226459688362 0.139846647346476 1.30671806167401 0.25 9.1 9 1 abnormal hair shaft morphology 0.073460820342511 0.243807592531015 1.30671806167401 0.25 9.1 9 1 abnormal phalanx morphology 0.073460820342511 0.243807592531015 1.30671806167401 0.25 9.1 9 1 abnormal uterus morphology 0.111862381190629 0.340947088864509 1.30671806167401 0.25 9.1 9 1 reduced long term depression 0.111862381190629 0.340947088864509 1.30671806167401 0.25 9.1 9 1 abnormal trophoblast giant cell morphology 0.111862381190629 0.340947088864509 1.30671806167401 0.25 9.1 9 1 abnormal lysosome morphology 0.111862381190629 0.340947088864509 1.30671806167401 0.25 9.1 9 1 abnormal body weight 0.176393839410957 0.398166674713934 1.30671806167401 0.25 9.1 9 1 abnormal sensory capabilities/reflexes/nociception 0.176393839410957 0.398166674713934 1.30671806167401 0.25 9.1 9 1 abnormal cellular extravasation 0.176393839410957 0.398166674713934 1.30671806167401 0.25 9.1 9 1 abnormal gait 3.83864008345055e-05 0.000819623794642339 1.30248920063299 0.249190938511327 9.1 9 1 increased neutrophil cell number 0.00423455204408662 0.0323608239928278 1.29770621297281 0.248275862068966 9.1 9 1 female infertility 0.000149942671995773 0.00252745425794467 1.29689311384187 0.24812030075188 9.1 9 1 increased B cell number 0.00974369264749957 0.0621472704119364 1.29554953123235 0.247863247863248 9.1 9 1 decreased IgM level 0.0178933858422678 0.0941959386374028 1.29324674145057 0.247422680412371 9.1 9 1 abnormal seminiferous tubule morphology 0.00476856443645916 0.0358904811972531 1.28881781425382 0.246575342465753 9.1 9 1 seizures 0.0123913304625012 0.0750875384298947 1.28379318339903 0.245614035087719 9.1 9 1 abnormal craniofacial development 0.0836790059295841 0.272093499672994 1.28005034612964 0.244897959183673 9.1 9 1 abnormal autopod morphology 0.0961007258724439 0.301071228725068 1.2776798825257 0.244444444444444 9.1 9 1 increased circulating corticosterone level 0.0961007258724439 0.301071228725068 1.2776798825257 0.244444444444444 9.1 9 1 hypoactivity 1.75430022083226e-05 0.000421625294620313 1.27552320078524 0.244031830238727 9.1 9 1 abnormal cholesterol homeostasis 0.110663256233663 0.340947088864509 1.27484688943806 0.24390243902439 9.1 9 1 absent gastric milk in neonates 0.0377040247689704 0.156706368609547 1.27321247034903 0.243589743589744 9.1 9 1 abnormal chromosome morphology 0.127841370521751 0.352751424484588 1.27140135730444 0.243243243243243 9.1 9 1 increased T cell proliferation 0.0177632595136185 0.0939130882893219 1.2700811066738 0.242990654205607 9.1 9 1 thick epidermis 0.0487181844934926 0.192359498297719 1.26938325991189 0.242857142857143 9.1 9 1 abnormal epidermis stratum basale morphology 0.148261727220423 0.371434909800017 1.26712054465358 0.242424242424242 9.1 9 1 decreased brown adipose tissue amount 0.148261727220423 0.371434909800017 1.26712054465358 0.242424242424242 9.1 9 1 decreased sensitivity to xenobiotic induced morbidity/mortality 0.148261727220423 0.371434909800017 1.26712054465358 0.242424242424242 9.1 9 1 myeloid hyperplasia 0.148261727220423 0.371434909800017 1.26712054465358 0.242424242424242 9.1 9 1 abnormal lens morphology 0.0108862751934719 0.0674689771218121 1.2658831222467 0.2421875 9.1 9 1 abnormal enzyme/coenzyme activity 0.00531284558942657 0.0390890766429131 1.26510283677993 0.24203821656051 9.1 9 1 abnormal embryonic neuroepithelium morphology 0.0722430583817873 0.240086316265459 1.26165881816801 0.241379310344828 9.1 9 1 abnormal enzyme/coenzyme level 0.0722430583817873 0.240086316265459 1.26165881816801 0.241379310344828 9.1 9 1 focal hair loss 0.172777037003805 0.393034183399146 1.26165881816801 0.241379310344828 9.1 9 1 increased susceptibility to induced arthritis 0.172777037003805 0.393034183399146 1.26165881816801 0.241379310344828 9.1 9 1 polychromatophilia 0.172777037003805 0.393034183399146 1.26165881816801 0.241379310344828 9.1 9 1 increased retinal apoptosis 0.172777037003805 0.393034183399146 1.26165881816801 0.241379310344828 9.1 9 1 abnormal coat/hair pigmentation 0.0176334224584535 0.093325826309368 1.26004955947137 0.241071428571429 9.1 9 1 polyphagia 0.0826478753843359 0.269621757401358 1.25832109642682 0.240740740740741 9.1 9 1 impaired limb coordination 0.0826478753843359 0.269621757401358 1.25832109642682 0.240740740740741 9.1 9 1 decreased double-positive T cell number 0.02544991783526 0.120345276109723 1.25444933920705 0.24 9.1 9 1 abnormal inner ear vestibule morphology 0.202594580678745 0.4399424002081 1.25444933920705 0.24 9.1 9 1 mandible hypoplasia 0.202594580678745 0.4399424002081 1.25444933920705 0.24 9.1 9 1 abnormal thyroid gland morphology 0.202594580678745 0.4399424002081 1.25444933920705 0.24 9.1 9 1 abnormal cochlear outer hair cell morphology 0.202594580678745 0.4399424002081 1.25444933920705 0.24 9.1 9 1 decreased acute inflammation 0.202594580678745 0.4399424002081 1.25444933920705 0.24 9.1 9 1 abnormal preimplantation embryo development 0.202594580678745 0.4399424002081 1.25444933920705 0.24 9.1 9 1 increased liver glycogen level 0.202594580678745 0.4399424002081 1.25444933920705 0.24 9.1 9 1 decreased neutrophil cell number 0.0174686653006899 0.0925523001820365 1.25087540946572 0.239316239316239 9.1 9 1 arrest of spermatogenesis 0.0418911576249457 0.170974781885633 1.24449339207048 0.238095238095238 9.1 9 1 abnormal nervous system electrophysiology 0.0418911576249457 0.170974781885633 1.24449339207048 0.238095238095238 9.1 9 1 abnormal vibrissa morphology 0.125412393415371 0.346433457657673 1.24449339207048 0.238095238095238 9.1 9 1 increased incidence of induced tumors 0.239516962561776 0.50555659259433 1.24449339207048 0.238095238095238 9.1 9 1 abnormal embryonic/fetal subventricular zone morphology 0.239516962561776 0.50555659259433 1.24449339207048 0.238095238095238 9.1 9 1 increased acute inflammation 0.239516962561776 0.50555659259433 1.24449339207048 0.238095238095238 9.1 9 1 abnormal stapes morphology 0.239516962561776 0.50555659259433 1.24449339207048 0.238095238095238 9.1 9 1 increased bone ossification 0.239516962561776 0.50555659259433 1.24449339207048 0.238095238095238 9.1 9 1 abnormal posture 0.0475461221790921 0.188479647682058 1.24138215859031 0.2375 9.1 9 1 increased bone marrow cell number 0.144956163473777 0.371434909800017 1.23794342684906 0.236842105263158 9.1 9 1 decreased threshold for auditory brainstem response 0.144956163473777 0.371434909800017 1.23794342684906 0.236842105263158 9.1 9 1 decreased T cell proliferation 0.0104704516248673 0.0655913805397971 1.23608465293487 0.236486486486486 9.1 9 1 decreased T cell number 0.00817588452708103 0.0543071524889828 1.23367171040031 0.236024844720497 9.1 9 1 decreased cytotoxic T cell cytolysis 0.168202395664737 0.383680384425522 1.22985229334024 0.235294117647059 9.1 9 1 abnormal skin physiology 0.168202395664737 0.383680384425522 1.22985229334024 0.235294117647059 9.1 9 1 hydroencephaly 0.0244658372883317 0.120345276109723 1.2271787013982 0.234782608695652 9.1 9 1 increased exploration in new environment 0.0531003571891764 0.207521034576711 1.2260564529287 0.234567901234568 9.1 9 1 increased sacral vertebrae number 0.0797610812764836 0.26123198113924 1.22504818281938 0.234375 9.1 9 1 abnormal immune system physiology 0.0213491774271748 0.108712546264273 1.22241367059827 0.233870967741935 9.1 9 1 abnormal cytokine secretion 0.0114493731475314 0.0704086914820377 1.22186623948738 0.233766233766234 9.1 9 1 abnormal estrous cycle 0.196123052884503 0.427381597941481 1.21960352422908 0.233333333333333 9.1 9 1 abnormal fat pad morphology 0.196123052884503 0.427381597941481 1.21960352422908 0.233333333333333 9.1 9 1 ataxia 0.00479599253960452 0.0360423910642485 1.21615344353819 0.232673267326733 9.1 9 1 abnormal homeostasis 0.141171209874501 0.371434909800017 1.21555168527815 0.232558139534884 9.1 9 1 abnormal axon guidance 0.141171209874501 0.371434909800017 1.21555168527815 0.232558139534884 9.1 9 1 hyperkeratosis 0.0780576855020322 0.257688775960591 1.21202834705995 0.231884057971014 9.1 9 1 abnormal food intake 0.0780576855020322 0.257688775960591 1.21202834705995 0.231884057971014 9.1 9 1 abnormal response/metabolism to endogenous compounds 0.0590959515606178 0.220722491752307 1.21110454496615 0.231707317073171 9.1 9 1 abnormal eye electrophysiology 0.0266558363143086 0.121366472772745 1.20952415626024 0.231404958677686 9.1 9 1 increased embryonic tissue cell apoptosis 0.0670941758575625 0.231273374881832 1.20620128769909 0.230769230769231 9.1 9 1 abnormal leukocyte migration 0.119390326989821 0.342197240675792 1.20620128769909 0.230769230769231 9.1 9 1 acanthosis 0.163155273798631 0.374923354651885 1.20620128769909 0.230769230769231 9.1 9 1 increased leukemia incidence 0.230087814043205 0.488139392266501 1.20620128769909 0.230769230769231 9.1 9 1 decreased circulating glycerol level 0.230087814043205 0.488139392266501 1.20620128769909 0.230769230769231 9.1 9 1 male infertility 3.98949719382959e-05 0.000837457744274354 1.19501055341957 0.228628230616302 9.1 9 1 dehydration 0.0867508709860435 0.276253795052111 1.19471365638767 0.228571428571429 9.1 9 1 decreased circulating thyroxine level 0.189282151067494 0.413016974368764 1.19471365638767 0.228571428571429 9.1 9 1 increased circulating alkaline phosphatase level 0.015095564913707 0.0848931745816101 1.19379180943058 0.228395061728395 9.1 9 1 impaired natural killer cell mediated cytotoxicity 0.116089641074592 0.342197240675792 1.1920936702991 0.228070175438596 9.1 9 1 increased T cell number 0.0639516402032403 0.229386741176006 1.18792551061274 0.227272727272727 9.1 9 1 hypertension 0.157902611225183 0.371434909800017 1.18792551061274 0.227272727272727 9.1 9 1 abnormal myelopoiesis 0.157902611225183 0.371434909800017 1.18792551061274 0.227272727272727 9.1 9 1 abnormal gametogenesis 0.157902611225183 0.371434909800017 1.18792551061274 0.227272727272727 9.1 9 1 intestinal ulcer 0.272124883710023 0.537536546315548 1.18792551061274 0.227272727272727 9.1 9 1 intestinal inflammation 0.272124883710023 0.537536546315548 1.18792551061274 0.227272727272727 9.1 9 1 testis hypoplasia 0.272124883710023 0.537536546315548 1.18792551061274 0.227272727272727 9.1 9 1 parakeratosis 0.272124883710023 0.537536546315548 1.18792551061274 0.227272727272727 9.1 9 1 abnormal female reproductive system physiology 0.272124883710023 0.537536546315548 1.18792551061274 0.227272727272727 9.1 9 1 abnormal limb posture 0.272124883710023 0.537536546315548 1.18792551061274 0.227272727272727 9.1 9 1 decreased circulating estradiol level 0.272124883710023 0.537536546315548 1.18792551061274 0.227272727272727 9.1 9 1 abnormal cerebral cortex pyramidal cell morphology 0.272124883710023 0.537536546315548 1.18792551061274 0.227272727272727 9.1 9 1 rough coat 0.272124883710023 0.537536546315548 1.18792551061274 0.227272727272727 9.1 9 1 increased eosinophil cell number 0.112712617907945 0.341293532618396 1.1802614750604 0.225806451612903 9.1 9 1 abnormal nose morphology 0.22062090611271 0.468854766301039 1.1802614750604 0.225806451612903 9.1 9 1 decreased thymus weight 0.22062090611271 0.468854766301039 1.1802614750604 0.225806451612903 9.1 9 1 decreased neuronal precursor cell number 0.22062090611271 0.468854766301039 1.1802614750604 0.225806451612903 9.1 9 1 abnormal CD8-positive, alpha beta T cell morphology 0.22062090611271 0.468854766301039 1.1802614750604 0.225806451612903 9.1 9 1 abnormal T cell proliferation 0.22062090611271 0.468854766301039 1.1802614750604 0.225806451612903 9.1 9 1 decreased susceptibility to bacterial infection induced morbidity/mortality 0.22062090611271 0.468854766301039 1.1802614750604 0.225806451612903 9.1 9 1 reduced long term potentiation 0.0509781885577633 0.199540903284715 1.16671255506608 0.223214285714286 9.1 9 1 decreased startle reflex 0.0496024245096227 0.195540461121532 1.16152716593245 0.222222222222222 9.1 9 1 abnormal neuronal precursor proliferation 0.147333981693946 0.371434909800017 1.16152716593245 0.222222222222222 9.1 9 1 rectal prolapse 0.258662380409103 0.522470703424803 1.16152716593245 0.222222222222222 9.1 9 1 decreased susceptibility to pharmacologically induced seizures 0.258662380409103 0.522470703424803 1.16152716593245 0.222222222222222 9.1 9 1 increased bone mineral density 0.055830389674249 0.211417716286054 1.15638766519824 0.221238938053097 9.1 9 1 decreased circulating alkaline phosphatase level 0.168917201829307 0.384957892396152 1.14991189427313 0.22 9.1 9 1 increased circulating chloride level 0.168917201829307 0.384957892396152 1.14991189427313 0.22 9.1 9 1 increased dopamine level 0.246121629591324 0.5079860241341 1.14337830396476 0.21875 9.1 9 1 decreased susceptibility to parasitic infection 0.246121629591324 0.5079860241341 1.14337830396476 0.21875 9.1 9 1 abnormal serotonin level 0.246121629591324 0.5079860241341 1.14337830396476 0.21875 9.1 9 1 abnormal urine homeostasis 0.082351053819443 0.269006232929566 1.14337830396476 0.21875 9.1 9 1 abnormal inner ear morphology 0.19408954835448 0.423321132425926 1.1362765753687 0.217391304347826 9.1 9 1 failure of embryo implantation 0.305580389801233 0.55342644312382 1.1362765753687 0.217391304347826 9.1 9 1 abnormal sacral vertebrae morphology 0.305580389801233 0.55342644312382 1.1362765753687 0.217391304347826 9.1 9 1 abnormal hepatocyte physiology 0.305580389801233 0.55342644312382 1.1362765753687 0.217391304347826 9.1 9 1 abnormal eye physiology 0.156294551547207 0.371434909800017 1.13248898678414 0.216666666666667 9.1 9 1 abnormal T cell activation 0.127490835054624 0.351979414204636 1.13013453982617 0.216216216216216 9.1 9 1 abnormal breathing pattern 0.234453316985965 0.495920600342337 1.13013453982617 0.216216216216216 9.1 9 1 decreased circulating chloride level 0.234453316985965 0.495920600342337 1.13013453982617 0.216216216216216 9.1 9 1 abnormal calcium ion homeostasis 0.234453316985965 0.495920600342337 1.13013453982617 0.216216216216216 9.1 9 1 abnormal gastrulation 0.186041642288922 0.406124252034834 1.12736460222856 0.215686274509804 9.1 9 1 decreased exploration in new environment 0.118503756985751 0.342197240675792 1.12004405286344 0.214285714285714 9.1 9 1 decreased circulating progesterone level 0.288101041809045 0.537536546315548 1.12004405286344 0.214285714285714 9.1 9 1 corneal vascularization 0.288101041809045 0.537536546315548 1.12004405286344 0.214285714285714 9.1 9 1 increased startle reflex 0.114253479672981 0.342197240675792 1.11584913131713 0.213483146067416 9.1 9 1 abnormal innervation 0.213428187434668 0.454734574941101 1.11210047802043 0.212765957446809 9.1 9 1 absent vibrissae 0.272468526383491 0.537536546315548 1.10873047657189 0.212121212121212 9.1 9 1 abnormal T cell subpopulation ratio 0.272468526383491 0.537536546315548 1.10873047657189 0.212121212121212 9.1 9 1 increased grooming behavior 0.258319224589216 0.522201601922531 1.10039415719917 0.210526315789474 9.1 9 1 abnormal reproductive system physiology 0.258319224589216 0.522201601922531 1.10039415719917 0.210526315789474 9.1 9 1 maternal effect 0.17871655580036 0.401769030775775 1.09218226050365 0.208955223880597 9.1 9 1 retinal degeneration 0.129237945689806 0.355422211059582 1.08893171806167 0.208333333333333 9.1 9 1 abnormal kidney physiology 0.233507532658542 0.494550862058853 1.08893171806167 0.208333333333333 9.1 9 1 thymus atrophy 0.233507532658542 0.494550862058853 1.08893171806167 0.208333333333333 9.1 9 1 abnormal nursing 0.339576850430253 0.599714174970006 1.08893171806167 0.208333333333333 9.1 9 1 increased stereotypic behavior 0.339576850430253 0.599714174970006 1.08893171806167 0.208333333333333 9.1 9 1 apnea 0.339576850430253 0.599714174970006 1.08893171806167 0.208333333333333 9.1 9 1 blindness 0.339576850430253 0.599714174970006 1.08893171806167 0.208333333333333 9.1 9 1 increased hemangiosarcoma incidence 0.339576850430253 0.599714174970006 1.08893171806167 0.208333333333333 9.1 9 1 abnormal retinal ganglion layer morphology 0.339576850430253 0.599714174970006 1.08893171806167 0.208333333333333 9.1 9 1 increased circulating total protein level 0.339576850430253 0.599714174970006 1.08893171806167 0.208333333333333 9.1 9 1 azoospermia 0.0692097060636815 0.231552311813595 1.0848225417671 0.207547169811321 9.1 9 1 abnormal coat/ hair morphology 0.222509619680886 0.472666677161574 1.0848225417671 0.207547169811321 9.1 9 1 sparse hair 0.15752438135771 0.371434909800017 1.08361985602235 0.207317073170732 9.1 9 1 abnormal CD8-positive, alpha-beta T cell physiology 0.318185564801716 0.566358921248136 1.08142184414401 0.206896551724138 9.1 9 1 decreased pancreatic beta cell number 0.299500486199463 0.544795217126994 1.07612075667271 0.205882352941176 9.1 9 1 increased autoantibody level 0.282877663502915 0.537536546315548 1.07217892239919 0.205128205128205 9.1 9 1 abnormal photoreceptor outer segment morphology 0.267893832077272 0.537536546315548 1.06913295955146 0.204545454545455 9.1 9 1 lethality, incomplete penetrance 0.267893832077272 0.537536546315548 1.06913295955146 0.204545454545455 9.1 9 1 abnormal cochlea morphology 0.241740596840336 0.5079860241341 1.06473323543808 0.203703703703704 9.1 9 1 abnormal epidermal layer morphology 0.209500706201673 0.448479351701086 1.06052480367746 0.202898550724638 9.1 9 1 abnormal spatial learning 0.0908831599078295 0.286166911735096 1.0582011296992 0.202453987730061 9.1 9 1 abnormal action potential 0.225718141539673 0.479277743986288 1.04537444933921 0.2 9.1 9 1 abnormal ectoderm development 0.290977216907956 0.537536546315548 1.04537444933921 0.2 9.1 9 1 short stride length 0.275587539477158 0.537536546315548 1.04537444933921 0.2 9.1 9 1 decreased circulating phosphate level 0.308003112633343 0.557408324973038 1.04537444933921 0.2 9.1 9 1 abnormal skin pigmentation 0.308003112633343 0.557408324973038 1.04537444933921 0.2 9.1 9 1 salivary gland inflammation 0.34870119278102 0.613432968205648 1.04537444933921 0.2 9.1 9 1 enhanced paired-pulse facilitation 0.34870119278102 0.613432968205648 1.04537444933921 0.2 9.1 9 1 impaired conditioned place preference behavior 0.373822417868129 0.648428888817094 1.04537444933921 0.2 9.1 9 1 abnormal B cell differentiation 0.201616741170786 0.439160808811148 1.03388681802779 0.197802197802198 9.1 9 1 abnormal eyelid morphology 0.379440461581414 0.653641376858565 1.01165269290891 0.193548387096774 9.1 9 1 abnormal hair growth 0.319690930709539 0.568428298884902 1.00516773974924 0.192307692307692 9.1 9 1 abnormal female meiosis 0.319690930709539 0.568428298884902 1.00516773974924 0.192307692307692 9.1 9 1 increased percent body fat/body weight 0.319690930709539 0.568428298884902 1.00516773974924 0.192307692307692 9.1 9 1 increased susceptibility to otitis media 0.408044942588349 0.662948877659121 1.00516773974924 0.192307692307692 9.1 9 1 deafness 0.233212425725183 0.494346748181842 1.00313709785075 0.191919191919192 9.1 9 1 abnormal CNS synaptic transmission 0.233212425725183 0.494346748181842 1.00313709785075 0.191919191919192 9.1 9 1 abnormal spermiogenesis 0.323807151651715 0.575335921238315 0.991303357132007 0.189655172413793 9.1 9 1 thrombocytosis 0.323807151651715 0.575335921238315 0.991303357132007 0.189655172413793 9.1 9 1 circling 0.28428713237262 0.537536546315548 0.983881834672195 0.188235294117647 9.1 9 1 abnormal T cell differentiation 0.261889363950954 0.528774182490258 0.983272996903214 0.188118811881188 9.1 9 1 abnormal crypts of Lieberkuhn morphology 0.410206345886819 0.665181411599389 0.980038546255507 0.1875 9.1 9 1 abnormal long term potentiation 0.410206345886819 0.665181411599389 0.980038546255507 0.1875 9.1 9 1 abnormal lymph node morphology 0.362720520221647 0.637870126582784 0.980038546255506 0.1875 9.1 9 1 abnormal locomotor activation 0.287139377262381 0.537536546315548 0.976448661470688 0.186813186813187 9.1 9 1 abnormal intestinal mucosa morphology 0.385517256251272 0.662948877659121 0.972441348222518 0.186046511627907 9.1 9 1 impaired fertilization 0.32986109369002 0.58421464617581 0.970704845814978 0.185714285714286 9.1 9 1 cryptorchism 0.441995524901814 0.704145823205391 0.96793930494371 0.185185185185185 9.1 9 1 hyporesponsive to tactile stimuli 0.411266708696844 0.666662623668329 0.96284488754927 0.184210526315789 9.1 9 1 abnormal retinal pigmentation 0.318146255178596 0.566358921248136 0.96126386146134 0.183908045977011 9.1 9 1 increased fluid intake 0.387125606083311 0.662948877659121 0.960037759597231 0.183673469387755 9.1 9 1 teratozoospermia 0.335462074482492 0.593923067811529 0.950340408490188 0.181818181818182 9.1 9 1 abnormal amino acid level 0.411655794956605 0.666662623668329 0.950340408490188 0.181818181818182 9.1 9 1 diarrhea 0.440814750220893 0.704145823205391 0.950340408490188 0.181818181818182 9.1 9 1 abnormal inflammatory response 0.369250638582203 0.646156147360696 0.943740822320117 0.180555555555556 9.1 9 1 abnormal NK cell physiology 0.388788900746247 0.662948877659121 0.94255073301076 0.180327868852459 9.1 9 1 abnormal digestive system physiology 0.411609571923686 0.666662623668329 0.940837004405286 0.18 9.1 9 1 testicular atrophy 0.411609571923686 0.666662623668329 0.940837004405286 0.18 9.1 9 1 abnormal leukocyte adhesion 0.439351812333016 0.703953386910388 0.938156557099288 0.179487179487179 9.1 9 1 decreased B-1 B cell number 0.439351812333016 0.703953386910388 0.938156557099288 0.179487179487179 9.1 9 1 myoclonus 0.475450847313285 0.754503338240381 0.933370044052863 0.178571428571429 9.1 9 1 reddish skin 0.475450847313285 0.754503338240381 0.933370044052863 0.178571428571429 9.1 9 1 abnormal spleen germinal center morphology 0.475450847313285 0.754503338240381 0.933370044052863 0.178571428571429 9.1 9 1 cochlear inner hair cell degeneration 0.436077051148904 0.700437909790601 0.922389220005183 0.176470588235294 9.1 9 1 abnormal oocyte morphology 0.471096378225484 0.748309221478858 0.922389220005183 0.176470588235294 9.1 9 1 abnormal sleep pattern 0.463686138973996 0.736773727689438 0.909021260294963 0.173913043478261 9.1 9 1 decreased IgA level 0.460436936822261 0.731844651977874 0.904650965774314 0.173076923076923 9.1 9 1 cochlear ganglion degeneration 0.4574126039436 0.727269959929501 0.901184870120006 0.172413793103448 9.1 9 1 decreased granulocyte number 0.508214447836529 0.764781269808449 0.901184870120006 0.172413793103448 9.1 9 1 impaired behavioral response to xenobiotic 0.500898028206801 0.757995590490704 0.896035242290749 0.171428571428571 9.1 9 1 abnormal excitatory postsynaptic potential 0.446917863236178 0.710810859846543 0.89239282260664 0.170731707317073 9.1 9 1 scaly skin 0.494728794781487 0.757995590490704 0.89239282260664 0.170731707317073 9.1 9 1 increased systemic arterial blood pressure 0.489366765419213 0.757995590490704 0.889680382416346 0.170212765957447 9.1 9 1 decreased monocyte cell number 0.476365057313543 0.755713061267498 0.884547610979329 0.169230769230769 9.1 9 1 diluted coat color 0.508494992877685 0.764972056113239 0.871145374449339 0.166666666666667 9.1 9 1 gastrointestinal hemorrhage 0.540117098847631 0.808631527766165 0.871145374449339 0.166666666666667 9.1 9 1 liver hemorrhage 0.540117098847631 0.808631527766165 0.871145374449339 0.166666666666667 9.1 9 1 increased susceptibility to bacterial infection induced morbidity/mortality 0.493423519270114 0.757995590490704 0.871145374449339 0.166666666666667 9.1 9 1 decreased urine osmolality 0.539587801458807 0.808325598391317 0.853366897419761 0.163265306122449 9.1 9 1 abnormal male reproductive system morphology 0.548281422741879 0.817655898723275 0.850886179694703 0.162790697674419 9.1 9 1 abnormal inhibitory postsynaptic currents 0.540470007891283 0.808916452845707 0.845523451671418 0.161764705882353 9.1 9 1 autoimmune response 0.571016452168058 0.845038402268173 0.843043910757425 0.161290322580645 9.1 9 1 abnormal intestine physiology 0.571016452168058 0.845038402268173 0.843043910757425 0.161290322580645 9.1 9 1 abnormal coat appearance 0.561236582790447 0.836224018982471 0.833269488603716 0.159420289855072 9.1 9 1 abnormal retinal outer nuclear layer morphology 0.586145764524726 0.848930182972492 0.825295617899374 0.157894736842105 9.1 9 1 increased susceptibility to pharmacologically induced seizures 0.589119332708496 0.852988556526416 0.816698788546255 0.15625 9.1 9 1 cochlear outer hair cell degeneration 0.621091438028144 0.891240237724262 0.798549926578561 0.152777777777778 9.1 9 1 impaired swimming 0.631137312675409 0.905394501314925 0.79195034040849 0.151515151515152 9.1 9 1 abnormal female reproductive system morphology 0.638533559241822 0.908527325023557 0.784030837004405 0.15 9.1 9 1 abnormal maternal nurturing 0.662619050062852 0.924952237391327 0.771177872463349 0.147540983606557 9.1 9 1 abnormal male meiosis 0.662619050062852 0.924952237391327 0.771177872463349 0.147540983606557 9.1 9 1 abnormal vision 0.656651755382716 0.917137137290571 0.768657683337652 0.147058823529412 9.1 9 1 increased susceptibility to parasitic infection 0.704907942248655 0.970547749852035 0.754992657856094 0.144444444444444 9.1 9 1 holoprosencephaly 0.682610709912036 0.949533584765008 0.746696035242291 0.142857142857143 9.1 9 1 enhanced long term potentiation 0.696161936769939 0.967702049575425 0.746696035242291 0.142857142857143 9.1 9 1 abnormal excitatory postsynaptic currents 0.726933248849358 0.99710309154275 0.737123009149441 0.141025641025641 9.1 9 1 head tilt 0.707211893395243 0.970855179260854 0.725954478707783 0.138888888888889 9.1 9 1 abnormal social investigation 0.757532141456404 1 0.718694933920705 0.1375 9.1 9 1 abnormal response to novel object 0.731873334855436 1 0.717413837781809 0.137254901960784 9.1 9 1 head bobbing 0.791999787602464 1 0.653359030837004 0.125 9.1 9 1 arrested B cell differentiation 0.809890618578101 1 0.637423444719029 0.121951219512195 9.1 9 1 cochlear hair cell degeneration 0.856254432717016 1 0.593962755306368 0.113636363636364 9.1 9 1 organ of Corti degeneration 0.912396679876065 1 0.533354310887351 0.102040816326531 9.1 9 1 abnormal aorta tunica adventitia morphology 2.60257694410708e-05 0.000541749803218942 4.80691543991784 1 9.2 9 2 ectopic ureteric bud 2.60257694410708e-05 0.000541749803218942 4.80691543991784 1 9.2 9 2 abnormal hypodermis morphology 0.000151236606762323 0.00226627144169446 4.80691543991784 1 9.2 9 2 decreased collagen level 0.000155312105447466 0.00230215750999752 4.12021323421529 0.857142857142857 9.2 9 2 calcified joint 0.000777290793368585 0.00843361448137447 4.0057628665982 0.833333333333333 9.2 9 2 abnormal periodontal ligament morphology 0.000777290793368585 0.00843361448137447 4.0057628665982 0.833333333333333 9.2 9 2 thick myocardium 0.000777290793368585 0.00843361448137447 4.0057628665982 0.833333333333333 9.2 9 2 abnormal intestinal enteroendocrine cell morphology 0.000777290793368585 0.00843361448137447 4.0057628665982 0.833333333333333 9.2 9 2 delayed limb development 0.000777290793368585 0.00843361448137447 4.0057628665982 0.833333333333333 9.2 9 2 abnormal palatal shelf elevation 5.20847879517459e-06 0.000142374626406558 3.93293081447823 0.818181818181818 9.2 9 2 increased pheochromocytoma incidence 0.000116385450696034 0.00183233423168599 3.73871200882498 0.777777777777778 9.2 9 2 decreased bone trabecular spacing 0.000116385450696034 0.00183233423168599 3.73871200882498 0.777777777777778 9.2 9 2 abnormal aorta tunica media morphology 3.91764755597939e-06 0.000113978342637412 3.69762726147526 0.769230769230769 9.2 9 2 failure of vascular branching 0.00052995354203928 0.00618901143578736 3.60518657993838 0.75 9.2 9 2 dry eyes 0.00052995354203928 0.00618901143578736 3.60518657993838 0.75 9.2 9 2 decreased corneal stroma thickness 0.00052995354203928 0.00618901143578736 3.60518657993838 0.75 9.2 9 2 absent tympanic ring 0.00052995354203928 0.00618901143578736 3.60518657993838 0.75 9.2 9 2 binucleate 0.00052995354203928 0.00618901143578736 3.60518657993838 0.75 9.2 9 2 abnormal vertebral body development 0.00052995354203928 0.00618901143578736 3.60518657993838 0.75 9.2 9 2 increased aorta wall thickness 0.00052995354203928 0.00618901143578736 3.60518657993838 0.75 9.2 9 2 abnormal heart echocardiography feature 0.00052995354203928 0.00618901143578736 3.60518657993838 0.75 9.2 9 2 abnormal aorta wall morphology 2.69792292629318e-06 8.44161418761545e-05 3.52507132260641 0.733333333333333 9.2 9 2 decreased atrioventricular cushion size 7.73621183963082e-05 0.00132950676058785 3.49593850175843 0.727272727272727 9.2 9 2 abnormal radial glial cell morphology 7.73621183963082e-05 0.00132950676058785 3.49593850175843 0.727272727272727 9.2 9 2 abnormal ureter development 7.73621183963082e-05 0.00132950676058785 3.49593850175843 0.727272727272727 9.2 9 2 pharyngeal arch hypoplasia 7.73621183963082e-05 0.00132950676058785 3.49593850175843 0.727272727272727 9.2 9 2 abnormal palate development 7.73621183963082e-05 0.00132950676058785 3.49593850175843 0.727272727272727 9.2 9 2 increased hemangioma incidence 1.15782013774082e-05 0.000276930537752913 3.43351102851274 0.714285714285714 9.2 9 2 abnormal sagittal suture morphology 1.15782013774082e-05 0.000276930537752913 3.43351102851274 0.714285714285714 9.2 9 2 growth retardation of molars 0.00233223751317138 0.0202493571169767 3.43351102851274 0.714285714285714 9.2 9 2 abnormal circulating alanine transaminase level 0.00233223751317138 0.0202493571169767 3.43351102851274 0.714285714285714 9.2 9 2 abnormal tumor incidence 0.00233223751317138 0.0202493571169767 3.43351102851274 0.714285714285714 9.2 9 2 increased muscle weight 0.00233223751317138 0.0202493571169767 3.43351102851274 0.714285714285714 9.2 9 2 skeletal muscle interstitial fibrosis 0.00233223751317138 0.0202493571169767 3.43351102851274 0.714285714285714 9.2 9 2 absent deltoid tuberosity 0.00233223751317138 0.0202493571169767 3.43351102851274 0.714285714285714 9.2 9 2 increased adrenocorticotropin level 0.00233223751317138 0.0202493571169767 3.43351102851274 0.714285714285714 9.2 9 2 atherosclerotic lesions 0.00233223751317138 0.0202493571169767 3.43351102851274 0.714285714285714 9.2 9 2 abnormal retina inner limiting membrane morphology 0.00233223751317138 0.0202493571169767 3.43351102851274 0.714285714285714 9.2 9 2 embryonic lethality at implantation, incomplete penetrance 0.00233223751317138 0.0202493571169767 3.43351102851274 0.714285714285714 9.2 9 2 hydroureter 1.7613077629229e-06 6.08507369482045e-05 3.39311678111847 0.705882352941177 9.2 9 2 fused cornea and lens 0.000329882432657926 0.00418664566957444 3.36484080794248 0.7 9.2 9 2 impaired basement membrane formation 0.000329882432657926 0.00418664566957444 3.36484080794248 0.7 9.2 9 2 lymphedema 0.000329882432657926 0.00418664566957444 3.36484080794248 0.7 9.2 9 2 bifid ureter 0.000329882432657926 0.00418664566957444 3.36484080794248 0.7 9.2 9 2 osteosclerosis 0.000329882432657926 0.00418664566957444 3.36484080794248 0.7 9.2 9 2 abnormal heart and great artery attachment 0.000329882432657926 0.00418664566957444 3.36484080794248 0.7 9.2 9 2 thin ventricle myocardium compact layer 0.000329882432657926 0.00418664566957444 3.36484080794248 0.7 9.2 9 2 abnormal ureter morphology 6.56898627566915e-09 4.08041943482237e-07 3.32786453532773 0.692307692307692 9.2 9 2 dilated ureter 2.93387582796386e-05 0.000593334644069926 3.20461029327856 0.666666666666667 9.2 9 2 abnormal pericyte morphology 2.93387582796386e-05 0.000593334644069926 3.20461029327856 0.666666666666667 9.2 9 2 abnormal rectum morphology 0.000196844443543611 0.00280602036283514 3.20461029327856 0.666666666666667 9.2 9 2 abnormal aorta elastic tissue morphology 0.000196844443543611 0.00280602036283514 3.20461029327856 0.666666666666667 9.2 9 2 decreased red blood cell distribution width 0.000196844443543611 0.00280602036283514 3.20461029327856 0.666666666666667 9.2 9 2 pancreas cysts 0.00135708972472577 0.0133166102179698 3.20461029327856 0.666666666666667 9.2 9 2 abnormal thymus physiology 0.00135708972472577 0.0133166102179698 3.20461029327856 0.666666666666667 9.2 9 2 positive geotaxis 0.00135708972472577 0.0133166102179698 3.20461029327856 0.666666666666667 9.2 9 2 iris coloboma 0.00135708972472577 0.0133166102179698 3.20461029327856 0.666666666666667 9.2 9 2 abnormal artery morphology 2.51375284767924e-10 2.15619317538004e-08 3.15883014623172 0.657142857142857 9.2 9 2 abnormal adipose tissue morphology 1.73972431637621e-05 0.000384672376620963 3.1103570493586 0.647058823529412 9.2 9 2 abnormal cranial suture morphology 1.73972431637621e-05 0.000384672376620963 3.1103570493586 0.647058823529412 9.2 9 2 premature suture closure 0.000771792982615753 0.00843361448137447 3.05894618903862 0.636363636363636 9.2 9 2 abnormal sphenoid bone morphology 0.000771792982615753 0.00843361448137447 3.05894618903862 0.636363636363636 9.2 9 2 abnormal coronal suture morphology 0.000771792982615753 0.00843361448137447 3.05894618903862 0.636363636363636 9.2 9 2 abnormal aorta smooth muscle morphology 0.000771792982615753 0.00843361448137447 3.05894618903862 0.636363636363636 9.2 9 2 loose skin 6.61035667481808e-05 0.00120463459550256 3.00432214994865 0.625 9.2 9 2 dilated respiratory conducting tubes 6.61035667481808e-05 0.00120463459550256 3.00432214994865 0.625 9.2 9 2 abnormal ear pigmentation 0.00533604413172489 0.0351613504044123 3.00432214994865 0.625 9.2 9 2 abnormal urination 0.00533604413172489 0.0351613504044123 3.00432214994865 0.625 9.2 9 2 preneoplasia 0.00533604413172489 0.0351613504044123 3.00432214994865 0.625 9.2 9 2 abnormal pulmonary circulation 0.00533604413172489 0.0351613504044123 3.00432214994865 0.625 9.2 9 2 short ureter 0.00533604413172489 0.0351613504044123 3.00432214994865 0.625 9.2 9 2 altered response to CNS ischemic injury 0.00533604413172489 0.0351613504044123 3.00432214994865 0.625 9.2 9 2 early eyelid opening 0.00533604413172489 0.0351613504044123 3.00432214994865 0.625 9.2 9 2 abnormal canal of Schlemm morphology 0.00533604413172489 0.0351613504044123 3.00432214994865 0.625 9.2 9 2 ocular hypertension 0.00533604413172489 0.0351613504044123 3.00432214994865 0.625 9.2 9 2 abnormal ilium morphology 0.00533604413172489 0.0351613504044123 3.00432214994865 0.625 9.2 9 2 skin fibrosis 0.00533604413172489 0.0351613504044123 3.00432214994865 0.625 9.2 9 2 decreased hippocampus pyramidal cell number 0.00533604413172489 0.0351613504044123 3.00432214994865 0.625 9.2 9 2 abnormal cerebellum deep nucleus morphology 0.00533604413172489 0.0351613504044123 3.00432214994865 0.625 9.2 9 2 abnormal lateral plate mesoderm morphology 0.00533604413172489 0.0351613504044123 3.00432214994865 0.625 9.2 9 2 delayed suture closure 0.00533604413172489 0.0351613504044123 3.00432214994865 0.625 9.2 9 2 decreased alveolar lamellar body number 0.00533604413172489 0.0351613504044123 3.00432214994865 0.625 9.2 9 2 abnormal bronchiole epithelium morphology 0.00533604413172489 0.0351613504044123 3.00432214994865 0.625 9.2 9 2 absent ureteric bud 0.00533604413172489 0.0351613504044123 3.00432214994865 0.625 9.2 9 2 abnormal kidney mesenchyme morphology 0.00533604413172489 0.0351613504044123 3.00432214994865 0.625 9.2 9 2 lethality during fetal growth through weaning, incomplete penetrance 0.00533604413172489 0.0351613504044123 3.00432214994865 0.625 9.2 9 2 abnormal umbilical vein topology 0.00533604413172489 0.0351613504044123 3.00432214994865 0.625 9.2 9 2 abnormal xiphoid process morphology 5.38527401147713e-07 2.01441640654878e-05 2.95810180918021 0.615384615384615 9.2 9 2 absent myocardial trabeculae 0.000434270114137098 0.00528238097269453 2.95810180918021 0.615384615384615 9.2 9 2 abnormal exocrine pancreas morphology 0.000434270114137098 0.00528238097269453 2.95810180918021 0.615384615384615 9.2 9 2 absent inner cell mass 3.77425563753351e-05 0.000748084533734232 2.93755943550534 0.611111111111111 9.2 9 2 increased bone resorption 3.11552035770302e-07 1.27528664302003e-05 2.91848437423583 0.607142857142857 9.2 9 2 abnormal prostate gland morphology 0.000243063752340979 0.00329493778718358 2.8841492639507 0.6 9.2 9 2 abnormal lymph node B cell domain morphology 0.000243063752340979 0.00329493778718358 2.8841492639507 0.6 9.2 9 2 decreased bone volume 1.67685622200932e-08 9.64160981504919e-07 2.8841492639507 0.6 9.2 9 2 absent maxillary shelf 0.00289790066282753 0.0239788161233256 2.8841492639507 0.6 9.2 9 2 intestinal hypoperistalsis 0.00289790066282753 0.0239788161233256 2.8841492639507 0.6 9.2 9 2 abnormal hindlimb zeugopod morphology 0.00289790066282753 0.0239788161233256 2.8841492639507 0.6 9.2 9 2 abnormal retinal blood vessel pattern 0.00289790066282753 0.0239788161233256 2.8841492639507 0.6 9.2 9 2 decreased macrophage cytokine production 0.00289790066282753 0.0239788161233256 2.8841492639507 0.6 9.2 9 2 decreased circulating lactate level 0.00289790066282753 0.0239788161233256 2.8841492639507 0.6 9.2 9 2 increased skin papilloma incidence 1.21311910949705e-05 0.000287393693797516 2.84045003267872 0.590909090909091 9.2 9 2 abnormal basement membrane morphology 1.21311910949705e-05 0.000287393693797516 2.84045003267872 0.590909090909091 9.2 9 2 interstitial pneumonia 0.00157672093731676 0.01474471177284 2.80403400661874 0.583333333333333 9.2 9 2 increased papilloma incidence 0.00157672093731676 0.01474471177284 2.80403400661874 0.583333333333333 9.2 9 2 increased growth rate 0.00157672093731676 0.01474471177284 2.80403400661874 0.583333333333333 9.2 9 2 abnormal aorta elastic fiber morphology 0.00157672093731676 0.01474471177284 2.80403400661874 0.583333333333333 9.2 9 2 dilated bile duct 0.00157672093731676 0.01474471177284 2.80403400661874 0.583333333333333 9.2 9 2 abnormal rostral-caudal body axis extension 0.00157672093731676 0.01474471177284 2.80403400661874 0.583333333333333 9.2 9 2 pale placenta 0.00157672093731676 0.01474471177284 2.80403400661874 0.583333333333333 9.2 9 2 hematuria 0.00157672093731676 0.01474471177284 2.80403400661874 0.583333333333333 9.2 9 2 decreased prostaglandin level 0.00157672093731676 0.01474471177284 2.80403400661874 0.583333333333333 9.2 9 2 persistent right dorsal aorta 0.00157672093731676 0.01474471177284 2.80403400661874 0.583333333333333 9.2 9 2 increased type II pneumocyte number 0.00157672093731676 0.01474471177284 2.80403400661874 0.583333333333333 9.2 9 2 abnormal capillary morphology 3.58779921819443e-07 1.42794408884138e-05 2.79111219092003 0.580645161290323 9.2 9 2 increased susceptibility to ischemic brain injury 7.56469981830839e-05 0.00132950676058785 2.78295104416296 0.578947368421053 9.2 9 2 complete atrioventricular septal defect 4.21545930822534e-05 0.000822427845428277 2.74680882281019 0.571428571428571 9.2 9 2 abnormal kidney blood vessel morphology 0.000860191925114325 0.00916227255012568 2.74680882281019 0.571428571428571 9.2 9 2 vascular smooth muscle hypoplasia 0.000860191925114325 0.00916227255012568 2.74680882281019 0.571428571428571 9.2 9 2 spina bifida occulta 0.000860191925114325 0.00916227255012568 2.74680882281019 0.571428571428571 9.2 9 2 abnormal epicardium morphology 0.000470583990960291 0.00564133820488541 2.70388993495378 0.5625 9.2 9 2 blepharitis 0.000470583990960291 0.00564133820488541 2.70388993495378 0.5625 9.2 9 2 kidney degeneration 0.000470583990960291 0.00564133820488541 2.70388993495378 0.5625 9.2 9 2 decreased fibroblast apoptosis 0.000470583990960291 0.00564133820488541 2.70388993495378 0.5625 9.2 9 2 decreased adipocyte glucose uptake 0.000470583990960291 0.00564133820488541 2.70388993495378 0.5625 9.2 9 2 abnormal interventricular septum morphology 6.44276867676413e-10 4.93119602567716e-08 2.69187264635399 0.56 9.2 9 2 abnormal cell adhesion 2.06621660946398e-10 1.80340835650585e-08 2.67050857773213 0.555555555555556 9.2 9 2 trabecula carnea hypoplasia 6.64349696925853e-09 4.08041943482237e-07 2.67050857773213 0.555555555555556 9.2 9 2 abnormal atrioventricular cushion morphology 7.29939434521172e-06 0.00018815796304367 2.67050857773213 0.555555555555556 9.2 9 2 abnormal mitral valve morphology 0.000258110869807012 0.00342427087277303 2.67050857773213 0.555555555555556 9.2 9 2 abnormal eye anterior chamber morphology 0.000258110869807012 0.00342427087277303 2.67050857773213 0.555555555555556 9.2 9 2 decreased level of surface class I molecules 0.0103097371404738 0.0574366654802433 2.67050857773213 0.555555555555556 9.2 9 2 biliary cyst 0.0103097371404738 0.0574366654802433 2.67050857773213 0.555555555555556 9.2 9 2 premature bone ossification 0.0103097371404738 0.0574366654802433 2.67050857773213 0.555555555555556 9.2 9 2 impaired febrile response 0.0103097371404738 0.0574366654802433 2.67050857773213 0.555555555555556 9.2 9 2 decreased cellular sensitivity to ionizing radiation 0.0103097371404738 0.0574366654802433 2.67050857773213 0.555555555555556 9.2 9 2 abnormal posterior eye segment morphology 0.0103097371404738 0.0574366654802433 2.67050857773213 0.555555555555556 9.2 9 2 abnormal cerebellar layer morphology 0.0103097371404738 0.0574366654802433 2.67050857773213 0.555555555555556 9.2 9 2 abnormal incisor color 0.0103097371404738 0.0574366654802433 2.67050857773213 0.555555555555556 9.2 9 2 abnormal ureteric bud invasion 0.0103097371404738 0.0574366654802433 2.67050857773213 0.555555555555556 9.2 9 2 kidney cysts 1.16833898007685e-13 1.66071040739495e-11 2.6632909869815 0.554054054054054 9.2 9 2 decreased skin tensile strength 0.000141905520154292 0.00213286997814986 2.64380349195481 0.55 9.2 9 2 kidney atrophy 0.000141905520154292 0.00213286997814986 2.64380349195481 0.55 9.2 9 2 abnormal induced retinal neovascularization 0.000141905520154292 0.00213286997814986 2.64380349195481 0.55 9.2 9 2 decreased muscle cell glucose uptake 0.000141905520154292 0.00213286997814986 2.64380349195481 0.55 9.2 9 2 small lung 1.19328440597454e-09 8.60375350684539e-08 2.63909082975881 0.549019607843137 9.2 9 2 omphalocele 2.16508192402938e-08 1.21025646876923e-06 2.62195387631882 0.545454545454545 9.2 9 2 abnormal vascular branching morphogenesis 7.81826754669926e-05 0.00133205072071332 2.62195387631882 0.545454545454545 9.2 9 2 failure of palatal shelf elevation 7.81826754669926e-05 0.00133205072071332 2.62195387631882 0.545454545454545 9.2 9 2 abnormal stomach epithelium morphology 0.00544922987908166 0.0356709455900411 2.62195387631882 0.545454545454545 9.2 9 2 delayed hepatic development 0.00544922987908166 0.0356709455900411 2.62195387631882 0.545454545454545 9.2 9 2 patent ductus arteriosus 0.00544922987908166 0.0356709455900411 2.62195387631882 0.545454545454545 9.2 9 2 aberrant origin of the right subclavian artery 0.00544922987908166 0.0356709455900411 2.62195387631882 0.545454545454545 9.2 9 2 decreased core body temperature 0.00544922987908166 0.0356709455900411 2.62195387631882 0.545454545454545 9.2 9 2 abnormal dermal layer morphology 7.08625918325435e-07 2.51815281690646e-05 2.60946838166968 0.542857142857143 9.2 9 2 abnormal truncus arteriosus septation 4.31560792498546e-05 0.000835414374583762 2.60374586328883 0.541666666666667 9.2 9 2 abnormal lung development 1.24474418640267e-14 2.21164368834045e-12 2.60138953219083 0.541176470588235 9.2 9 2 increased leukemia incidence 2.38619545565345e-05 0.000503022135248979 2.58833908303268 0.538461538461538 9.2 9 2 absent trabeculae carneae 0.00290958023102636 0.0239788161233256 2.58833908303268 0.538461538461538 9.2 9 2 increased cochlear inner hair cell number 0.00290958023102636 0.0239788161233256 2.58833908303268 0.538461538461538 9.2 9 2 absent hypoglossal nerve 0.00290958023102636 0.0239788161233256 2.58833908303268 0.538461538461538 9.2 9 2 abnormal cell differentiation 1.23858011528588e-07 5.70549636439562e-06 2.57932047995591 0.536585365853659 9.2 9 2 absent corpus callosum 1.32137326338575e-05 0.000307188410530098 2.57513327138455 0.535714285714286 9.2 9 2 absent incisors 0.00156548126542672 0.01474471177284 2.56368823462285 0.533333333333333 9.2 9 2 vagina atresia 0.00156548126542672 0.01474471177284 2.56368823462285 0.533333333333333 9.2 9 2 arthritis 0.00156548126542672 0.01474471177284 2.56368823462285 0.533333333333333 9.2 9 2 delayed intramembranous bone ossification 0.00156548126542672 0.01474471177284 2.56368823462285 0.533333333333333 9.2 9 2 increased fibroblast apoptosis 4.06789491183183e-06 0.000116981371019441 2.55367382745635 0.53125 9.2 9 2 abnormal vascular development 3.83845409398635e-11 3.7443743367808e-09 2.54912182419885 0.53030303030303 9.2 9 2 abnormal bone remodeling 2.26091393594246e-06 7.30392651384011e-05 2.54483758583885 0.529411764705882 9.2 9 2 increased trabecular bone mass 0.000847346448152526 0.00910485654332358 2.54483758583885 0.529411764705882 9.2 9 2 decreased body fat mass 0.000847346448152526 0.00910485654332358 2.54483758583885 0.529411764705882 9.2 9 2 hydrops fetalis 6.83426838142532e-12 7.72738299945249e-10 2.53698314884553 0.527777777777778 9.2 9 2 abnormal angiogenesis 3.84542588101934e-12 4.66609603855395e-10 2.53337435347021 0.527027027027027 9.2 9 2 thin dermal layer 0.000460848504944708 0.00559200320024372 2.5299554946936 0.526315789473684 9.2 9 2 abnormal vitelline vasculature morphology 1.28478094692577e-17 3.75987365350336e-15 2.50795588169626 0.521739130434783 9.2 9 2 abnormal hematopoietic stem cell physiology 0.000137847611382538 0.00209722283372515 2.50795588169626 0.521739130434783 9.2 9 2 overriding aortic valve 3.79192299261604e-08 1.98577019876472e-06 2.50360179162387 0.520833333333333 9.2 9 2 abnormal fetal cardiomyocyte proliferation 4.1698557861036e-05 0.000816733564404151 2.49247467254999 0.518518518518518 9.2 9 2 decreased bone mineralization 3.90451301341932e-06 0.000113978342637412 2.47212794052917 0.514285714285714 9.2 9 2 double outlet right ventricle 6.70210171982554e-16 1.38928983567217e-13 2.4708443850045 0.514018691588785 9.2 9 2 decreased width of hypertrophic chondrocyte zone 2.16756601980156e-06 7.05023621554694e-05 2.46841603671456 0.513513513513513 9.2 9 2 abnormal myocardial trabeculae morphology 2.079784432006e-07 8.99732830367813e-06 2.45686789151356 0.511111111111111 9.2 9 2 intracranial hemorrhage 5.90469547057508e-09 3.81504674884559e-07 2.40345771995892 0.5 9.2 9 2 small heart 1.94068984195983e-07 8.46923856469314e-06 2.40345771995892 0.5 9.2 9 2 delayed wound healing 3.48097388332571e-07 1.39660040883431e-05 2.40345771995892 0.5 9.2 9 2 kidney cortex cysts 2.13703246307935e-05 0.000456297704026599 2.40345771995892 0.5 9.2 9 2 abnormal brain vasculature morphology 3.86908099419212e-05 0.000763836426432769 2.40345771995892 0.5 9.2 9 2 ventricular hypoplasia 0.000127589039616749 0.00198361085029165 2.40345771995892 0.5 9.2 9 2 heart inflammation 0.000127589039616749 0.00198361085029165 2.40345771995892 0.5 9.2 9 2 abnormal foregut morphology 0.000232539143515221 0.0031870034131907 2.40345771995892 0.5 9.2 9 2 abnormal basisphenoid bone morphology 0.000425080404400076 0.00520880544800586 2.40345771995892 0.5 9.2 9 2 abnormal chorion morphology 0.000425080404400076 0.00520880544800586 2.40345771995892 0.5 9.2 9 2 abnormal tracheal cartilage morphology 0.000425080404400076 0.00520880544800586 2.40345771995892 0.5 9.2 9 2 cleft upper lip 0.000425080404400076 0.00520880544800586 2.40345771995892 0.5 9.2 9 2 decreased cellular sensitivity to gamma-irradiation 0.00143658202649804 0.0139862927237334 2.40345771995892 0.5 9.2 9 2 abnormal bone marrow cell number 0.00266037853989316 0.0224709392800823 2.40345771995892 0.5 9.2 9 2 poor circulation 0.00266037853989316 0.0224709392800823 2.40345771995892 0.5 9.2 9 2 disorganized yolk sac vascular plexus 0.00266037853989316 0.0224709392800823 2.40345771995892 0.5 9.2 9 2 abnormal pulmonary elastic fiber morphology 0.00266037853989316 0.0224709392800823 2.40345771995892 0.5 9.2 9 2 bowed tibia 0.00266037853989316 0.0224709392800823 2.40345771995892 0.5 9.2 9 2 bowed radius 0.00266037853989316 0.0224709392800823 2.40345771995892 0.5 9.2 9 2 increased cochlear outer hair cell number 0.00266037853989316 0.0224709392800823 2.40345771995892 0.5 9.2 9 2 abnormal pulmonary alveolus wall morphology 0.00266037853989316 0.0224709392800823 2.40345771995892 0.5 9.2 9 2 abnormal supraoccipital bone morphology 0.00932173882084657 0.0551434609199901 2.40345771995892 0.5 9.2 9 2 abnormal thymus involution 0.00932173882084657 0.0551434609199901 2.40345771995892 0.5 9.2 9 2 loss of dopaminergic neurons 0.00932173882084657 0.0551434609199901 2.40345771995892 0.5 9.2 9 2 absent tail 0.00932173882084657 0.0551434609199901 2.40345771995892 0.5 9.2 9 2 abnormal vascular endothelial cell development 0.00932173882084657 0.0551434609199901 2.40345771995892 0.5 9.2 9 2 increased hepatocyte proliferation 0.00932173882084657 0.0551434609199901 2.40345771995892 0.5 9.2 9 2 abnormal fatty acid level 0.00932173882084657 0.0551434609199901 2.40345771995892 0.5 9.2 9 2 decreased mammary gland epithelial cell proliferation 0.00932173882084657 0.0551434609199901 2.40345771995892 0.5 9.2 9 2 abnormal colon goblet cell morphology 0.00932173882084657 0.0551434609199901 2.40345771995892 0.5 9.2 9 2 abnormal pericardium morphology 0.000779791489735127 0.00843361448137447 2.40345771995892 0.5 9.2 9 2 absent ductus venosus valve 0.000779791489735127 0.00843361448137447 2.40345771995892 0.5 9.2 9 2 translucent skin 0.0049589685369384 0.0351613504044123 2.40345771995892 0.5 9.2 9 2 irregularly shaped pupil 0.0049589685369384 0.0351613504044123 2.40345771995892 0.5 9.2 9 2 abnormal decidualization 0.0049589685369384 0.0351613504044123 2.40345771995892 0.5 9.2 9 2 decreased cornea thickness 0.0049589685369384 0.0351613504044123 2.40345771995892 0.5 9.2 9 2 pulmonary alveolar hemorrhage 0.0049589685369384 0.0351613504044123 2.40345771995892 0.5 9.2 9 2 decreased compact bone area 0.0049589685369384 0.0351613504044123 2.40345771995892 0.5 9.2 9 2 enlarged testis 0.0177215736181201 0.0877685584245696 2.40345771995892 0.5 9.2 9 2 absent trophoblast giant cells 0.0177215736181201 0.0877685584245696 2.40345771995892 0.5 9.2 9 2 abnormal airway responsiveness 0.0177215736181201 0.0877685584245696 2.40345771995892 0.5 9.2 9 2 abnormal primordial germ cell migration 0.0177215736181201 0.0877685584245696 2.40345771995892 0.5 9.2 9 2 abnormal bone healing 0.0177215736181201 0.0877685584245696 2.40345771995892 0.5 9.2 9 2 delayed dark adaptation 0.0177215736181201 0.0877685584245696 2.40345771995892 0.5 9.2 9 2 aneurysm 0.0177215736181201 0.0877685584245696 2.40345771995892 0.5 9.2 9 2 absent seminal vesicle 0.0177215736181201 0.0877685584245696 2.40345771995892 0.5 9.2 9 2 abnormal glial cell physiology 0.0177215736181201 0.0877685584245696 2.40345771995892 0.5 9.2 9 2 increased atrioventricular cushion size 0.0177215736181201 0.0877685584245696 2.40345771995892 0.5 9.2 9 2 increased heart rate variability 0.0177215736181201 0.0877685584245696 2.40345771995892 0.5 9.2 9 2 increased susceptibility to atherosclerosis 0.0177215736181201 0.0877685584245696 2.40345771995892 0.5 9.2 9 2 vascular smooth muscle hyperplasia 0.0177215736181201 0.0877685584245696 2.40345771995892 0.5 9.2 9 2 abnormal developmental vascular remodeling 0.0177215736181201 0.0877685584245696 2.40345771995892 0.5 9.2 9 2 decreased transitional stage T2 B cell number 0.0177215736181201 0.0877685584245696 2.40345771995892 0.5 9.2 9 2 increased circulating fructosamine level 0.0177215736181201 0.0877685584245696 2.40345771995892 0.5 9.2 9 2 fusion of atlas and odontoid process 0.0177215736181201 0.0877685584245696 2.40345771995892 0.5 9.2 9 2 decreased trabecular bone connectivity density 0.0177215736181201 0.0877685584245696 2.40345771995892 0.5 9.2 9 2 absent vitelline blood vessels 3.09958061845984e-08 1.65810898675674e-06 2.36129179504736 0.491228070175439 9.2 9 2 decreased bone trabecula number 5.70529699551088e-07 2.11819795169154e-05 2.35232032166192 0.48936170212766 9.2 9 2 kidney failure 1.83807570941021e-06 6.30650114090746e-05 2.34756335437848 0.488372093023256 9.2 9 2 hemopericardium 3.30351279547297e-06 9.84130308831021e-05 2.34483679995992 0.48780487804878 9.2 9 2 short mandible 8.94786767687683e-08 4.32190696043323e-06 2.3176199442461 0.482142857142857 9.2 9 2 abnormal mandible morphology 1.59963578072091e-07 7.10552500811298e-06 2.31444076736785 0.481481481481481 9.2 9 2 abnormal skin appearance 0.000207344486961339 0.00290574316234553 2.31444076736785 0.481481481481481 9.2 9 2 decreased circulating fructosamine level 0.000207344486961339 0.00290574316234553 2.31444076736785 0.481481481481481 9.2 9 2 delayed bone ossification 7.83046315231108e-10 5.90250820950722e-08 2.30731941116056 0.48 9.2 9 2 mandible hypoplasia 0.000377290201756987 0.00476400698919038 2.30731941116056 0.48 9.2 9 2 abnormal palatal shelf fusion at midline 0.000688377131332819 0.00774813626330492 2.29895955822157 0.478260869565217 9.2 9 2 abnormal erythropoiesis 6.30219143909021e-13 8.70927844707605e-11 2.28900735234183 0.476190476190476 9.2 9 2 spina bifida 5.28610101420713e-06 0.000142925829052611 2.28900735234183 0.476190476190476 9.2 9 2 increased muscle cell glucose uptake 0.00125993689864567 0.0126120444079722 2.28900735234183 0.476190476190476 9.2 9 2 impaired branching involved in ureteric bud morphogenesis 1.70664878128408e-05 0.000380743394030865 2.27695994522424 0.473684210526316 9.2 9 2 enlarged adrenal glands 0.00231474219589604 0.0202493571169767 2.27695994522424 0.473684210526316 9.2 9 2 abnormal metatarsal bone morphology 0.00231474219589604 0.0202493571169767 2.27695994522424 0.473684210526316 9.2 9 2 increased liver adenoma incidence 0.00231474219589604 0.0202493571169767 2.27695994522424 0.473684210526316 9.2 9 2 osteoarthritis 0.00231474219589604 0.0202493571169767 2.27695994522424 0.473684210526316 9.2 9 2 abnormal blastocyst morphology 0.00231474219589604 0.0202493571169767 2.27695994522424 0.473684210526316 9.2 9 2 increased liver cholesterol level 0.00231474219589604 0.0202493571169767 2.27695994522424 0.473684210526316 9.2 9 2 enlarged liver sinusoidal spaces 5.53287500264851e-05 0.00104661799004473 2.26207785407898 0.470588235294118 9.2 9 2 lung hemorrhage 5.53287500264851e-05 0.00104661799004473 2.26207785407898 0.470588235294118 9.2 9 2 abnormal bone marrow cavity morphology 0.00427196262144039 0.031815889283931 2.26207785407898 0.470588235294118 9.2 9 2 increased incidence of corneal inflammation 0.00427196262144039 0.031815889283931 2.26207785407898 0.470588235294118 9.2 9 2 pancytopenia 0.00427196262144039 0.031815889283931 2.26207785407898 0.470588235294118 9.2 9 2 increased brain size 0.00427196262144039 0.031815889283931 2.26207785407898 0.470588235294118 9.2 9 2 abnormal tendon morphology 0.00427196262144039 0.031815889283931 2.26207785407898 0.470588235294118 9.2 9 2 enhanced behavioral response to cocaine 0.00427196262144039 0.031815889283931 2.26207785407898 0.470588235294118 9.2 9 2 delayed heart development 0.00427196262144039 0.031815889283931 2.26207785407898 0.470588235294118 9.2 9 2 abnormal cell cytoskeleton morphology 0.00427196262144039 0.031815889283931 2.26207785407898 0.470588235294118 9.2 9 2 pale yolk sac 3.47402529716872e-10 2.88054597556907e-08 2.25867111032284 0.469879518072289 9.2 9 2 abnormal skeleton development 6.16822909856475e-10 4.79483433833744e-08 2.25509613230713 0.469135802469136 9.2 9 2 abnormal vertebral body morphology 9.98060031645772e-05 0.00162798316637302 2.25324161246149 0.46875 9.2 9 2 scoliosis 9.98060031645772e-05 0.00162798316637302 2.25324161246149 0.46875 9.2 9 2 abnormal depression-related behavior 9.98060031645772e-05 0.00162798316637302 2.25324161246149 0.46875 9.2 9 2 abnormal embryonic hematopoiesis 9.98060031645772e-05 0.00162798316637302 2.25324161246149 0.46875 9.2 9 2 pulmonary hypoplasia 2.58652469641673e-06 8.19615309851799e-05 2.25004552506792 0.468085106382979 9.2 9 2 spleen hyperplasia 3.45386257625903e-09 2.29106217558516e-07 2.24322720529499 0.466666666666667 9.2 9 2 delayed eyelid opening 0.000180294620036925 0.00263039804892582 2.24322720529499 0.466666666666667 9.2 9 2 abnormal lactation 0.000180294620036925 0.00263039804892582 2.24322720529499 0.466666666666667 9.2 9 2 hyperpigmentation 0.0079282698995111 0.0482780205019189 2.24322720529499 0.466666666666667 9.2 9 2 absent egg cylinders 0.0079282698995111 0.0482780205019189 2.24322720529499 0.466666666666667 9.2 9 2 abnormal ear development 0.0079282698995111 0.0482780205019189 2.24322720529499 0.466666666666667 9.2 9 2 abnormal olfactory nerve morphology 0.0079282698995111 0.0482780205019189 2.24322720529499 0.466666666666667 9.2 9 2 abnormal energy homeostasis 0.0079282698995111 0.0482780205019189 2.24322720529499 0.466666666666667 9.2 9 2 abnormal secondary palate development 0.0079282698995111 0.0482780205019189 2.24322720529499 0.466666666666667 9.2 9 2 abnormal coronary vessel morphology 0.0079282698995111 0.0482780205019189 2.24322720529499 0.466666666666667 9.2 9 2 delayed endochondral bone ossification 8.28438388794357e-06 0.000211357999192407 2.2357746232176 0.465116279069767 9.2 9 2 corneal vascularization 0.000326217443651381 0.00418664566957444 2.23178216853328 0.464285714285714 9.2 9 2 abnormal mammary gland development 1.48398405673035e-05 0.000336080038328458 2.22759495996192 0.463414634146341 9.2 9 2 ventricular septal defect 3.48450673356506e-15 6.42052629610598e-13 2.226732887609 0.463235294117647 9.2 9 2 lethality throughout fetal growth and development, complete penetrance 1.30556700475577e-20 5.90472349878179e-18 2.22636083533037 0.463157894736842 9.2 9 2 abnormal apoptosis 7.05620194337642e-07 2.51815281690646e-05 2.22542381477678 0.462962962962963 9.2 9 2 decreased tumor growth/size 7.05620194337642e-07 2.51815281690646e-05 2.22542381477678 0.462962962962963 9.2 9 2 impaired macrophage chemotaxis 2.66007166514913e-05 0.000546853575789955 2.21857635688516 0.461538461538462 9.2 9 2 decreased trabecular bone volume 2.66007166514913e-05 0.000546853575789955 2.21857635688516 0.461538461538462 9.2 9 2 increased foot pad pigmentation 0.0148178747549782 0.0778446957824884 2.21857635688516 0.461538461538462 9.2 9 2 pup cannibalization 0.0148178747549782 0.0778446957824884 2.21857635688516 0.461538461538462 9.2 9 2 lymphoid hypoplasia 0.0148178747549782 0.0778446957824884 2.21857635688516 0.461538461538462 9.2 9 2 abnormal lung interstitium morphology 0.0148178747549782 0.0778446957824884 2.21857635688516 0.461538461538462 9.2 9 2 abnormal tail bud morphology 0.0148178747549782 0.0778446957824884 2.21857635688516 0.461538461538462 9.2 9 2 anal atresia 0.0148178747549782 0.0778446957824884 2.21857635688516 0.461538461538462 9.2 9 2 abnormal skeleton morphology 6.72221433027748e-13 9.03865305219742e-11 2.2153610288317 0.460869565217391 9.2 9 2 decreased body height 0.00107408619794771 0.011007945649027 2.20316957662901 0.458333333333333 9.2 9 2 abnormal body weight 0.00107408619794771 0.011007945649027 2.20316957662901 0.458333333333333 9.2 9 2 cleft palate 2.95463166417942e-14 4.45433106948261e-12 2.20164065950435 0.458015267175573 9.2 9 2 thick pulmonary interalveolar septum 8.56667463981749e-05 0.00143499011222532 2.19744705824815 0.457142857142857 9.2 9 2 abnormal forelimb morphology 7.13491689266619e-06 0.000184876101776116 2.19446139648423 0.456521739130435 9.2 9 2 abnormal aorta morphology 0.000153931296204494 0.00229283891801605 2.18496156359902 0.454545454545455 9.2 9 2 abnormal skeleton physiology 0.000153931296204494 0.00229283891801605 2.18496156359902 0.454545454545455 9.2 9 2 intracerebral hemorrhage 0.00195565064385032 0.017689749005737 2.18496156359902 0.454545454545455 9.2 9 2 abnormal cochlear sensory epithelium morphology 0.00195565064385032 0.017689749005737 2.18496156359902 0.454545454545455 9.2 9 2 abnormal ear position 0.0279485267339854 0.124802435469392 2.18496156359902 0.454545454545455 9.2 9 2 increased mast cell number 0.0279485267339854 0.124802435469392 2.18496156359902 0.454545454545455 9.2 9 2 enlarged cranium 0.0279485267339854 0.124802435469392 2.18496156359902 0.454545454545455 9.2 9 2 abnormal large intestine morphology 0.0279485267339854 0.124802435469392 2.18496156359902 0.454545454545455 9.2 9 2 abnormal glossopharyngeal ganglion morphology 0.0279485267339854 0.124802435469392 2.18496156359902 0.454545454545455 9.2 9 2 abnormal hemoglobin 0.0279485267339854 0.124802435469392 2.18496156359902 0.454545454545455 9.2 9 2 abnormal bronchiole morphology 0.0279485267339854 0.124802435469392 2.18496156359902 0.454545454545455 9.2 9 2 retinal detachment 0.0279485267339854 0.124802435469392 2.18496156359902 0.454545454545455 9.2 9 2 fused joints 0.0279485267339854 0.124802435469392 2.18496156359902 0.454545454545455 9.2 9 2 rectal hemorrhage 0.0279485267339854 0.124802435469392 2.18496156359902 0.454545454545455 9.2 9 2 impaired luteinization 0.0279485267339854 0.124802435469392 2.18496156359902 0.454545454545455 9.2 9 2 abnormal lymph circulation 0.0279485267339854 0.124802435469392 2.18496156359902 0.454545454545455 9.2 9 2 dilated renal glomerular capsule 0.0279485267339854 0.124802435469392 2.18496156359902 0.454545454545455 9.2 9 2 abnormal pituitary gland development 0.0279485267339854 0.124802435469392 2.18496156359902 0.454545454545455 9.2 9 2 abnormal Bruch membrane morphology 0.0279485267339854 0.124802435469392 2.18496156359902 0.454545454545455 9.2 9 2 abnormal superovulation 0.0279485267339854 0.124802435469392 2.18496156359902 0.454545454545455 9.2 9 2 common atrioventricular valve 0.0279485267339854 0.124802435469392 2.18496156359902 0.454545454545455 9.2 9 2 abnormal pulmonary alveolar sac morphology 0.0279485267339854 0.124802435469392 2.18496156359902 0.454545454545455 9.2 9 2 increased subcutaneous adipose tissue amount 0.0279485267339854 0.124802435469392 2.18496156359902 0.454545454545455 9.2 9 2 abnormal phrenic nerve innervation pattern to diaphragm 0.0279485267339854 0.124802435469392 2.18496156359902 0.454545454545455 9.2 9 2 thin hypoglossal nerve 0.0279485267339854 0.124802435469392 2.18496156359902 0.454545454545455 9.2 9 2 reduced sympathetic cervical ganglion size 0.0279485267339854 0.124802435469392 2.18496156359902 0.454545454545455 9.2 9 2 enlarged kidney 1.92368745177125e-06 6.54840652180433e-05 2.17671642562317 0.452830188679245 9.2 9 2 abnormal cartilage morphology 2.27320601981224e-05 0.000481242551002803 2.17455698472474 0.452380952380952 9.2 9 2 pericardial effusion 2.93869968109685e-07 1.21833590945474e-05 2.17086503738225 0.451612903225806 9.2 9 2 pale kidney 0.000276857842189328 0.00365349539759126 2.17086503738225 0.451612903225806 9.2 9 2 abnormal cell proliferation 0.00357061095548224 0.0282862890183506 2.16311194796303 0.45 9.2 9 2 anencephaly 0.00357061095548224 0.0282862890183506 2.16311194796303 0.45 9.2 9 2 spleen atrophy 0.00357061095548224 0.0282862890183506 2.16311194796303 0.45 9.2 9 2 abnormal physiological neovascularization 0.00357061095548224 0.0282862890183506 2.16311194796303 0.45 9.2 9 2 abnormal heart right ventricle morphology 0.00357061095548224 0.0282862890183506 2.16311194796303 0.45 9.2 9 2 dilated vasculature 0.00357061095548224 0.0282862890183506 2.16311194796303 0.45 9.2 9 2 abnormal neuron proliferation 0.00357061095548224 0.0282862890183506 2.16311194796303 0.45 9.2 9 2 small liver 1.23746369986813e-08 7.2428022433458e-07 2.15694923586057 0.448717948717949 9.2 9 2 decreased trophoblast giant cell number 0.00049847118249915 0.00594698832837715 2.15482416272179 0.448275862068966 9.2 9 2 abnormal frontal bone morphology 7.25303296028001e-05 0.00128870853490689 2.15046217048956 0.447368421052632 9.2 9 2 incomplete somite formation 7.25303296028001e-05 0.00128870853490689 2.15046217048956 0.447368421052632 9.2 9 2 abnormal compact bone morphology 7.25303296028001e-05 0.00128870853490689 2.15046217048956 0.447368421052632 9.2 9 2 hemorrhage 8.64940321281045e-23 5.3788476229665e-20 2.14777072847393 0.446808510638298 9.2 9 2 abnormal maxilla morphology 2.89814125771817e-06 8.91694924637975e-05 2.13640686218571 0.444444444444444 9.2 9 2 abnormal uterus morphology 0.000129631058898183 0.00199047690746439 2.13640686218571 0.444444444444444 9.2 9 2 impaired wound healing 0.000129631058898183 0.00199047690746439 2.13640686218571 0.444444444444444 9.2 9 2 renal hypoplasia 0.000129631058898183 0.00199047690746439 2.13640686218571 0.444444444444444 9.2 9 2 short radius 0.000129631058898183 0.00199047690746439 2.13640686218571 0.444444444444444 9.2 9 2 rectal prolapse 0.000898499995181297 0.00937114774848417 2.13640686218571 0.444444444444444 9.2 9 2 increased brain weight 0.000898499995181297 0.00937114774848417 2.13640686218571 0.444444444444444 9.2 9 2 decreased bone ossification 0.000898499995181297 0.00937114774848417 2.13640686218571 0.444444444444444 9.2 9 2 abnormal heart shape 0.00654026709739427 0.0412916609258077 2.13640686218571 0.444444444444444 9.2 9 2 abnormal mammary gland morphology 0.00654026709739427 0.0412916609258077 2.13640686218571 0.444444444444444 9.2 9 2 thick dermal layer 0.00654026709739427 0.0412916609258077 2.13640686218571 0.444444444444444 9.2 9 2 blepharoptosis 0.00654026709739427 0.0412916609258077 2.13640686218571 0.444444444444444 9.2 9 2 abnormal bile duct morphology 0.00654026709739427 0.0412916609258077 2.13640686218571 0.444444444444444 9.2 9 2 abnormal metacarpal bone morphology 0.00654026709739427 0.0412916609258077 2.13640686218571 0.444444444444444 9.2 9 2 absent allantois 0.00654026709739427 0.0412916609258077 2.13640686218571 0.444444444444444 9.2 9 2 abnormal body wall morphology 0.00654026709739427 0.0412916609258077 2.13640686218571 0.444444444444444 9.2 9 2 abnormal anterior eye segment morphology 0.00654026709739427 0.0412916609258077 2.13640686218571 0.444444444444444 9.2 9 2 abnormal pregnancy 0.00654026709739427 0.0412916609258077 2.13640686218571 0.444444444444444 9.2 9 2 decreased fluid intake 0.00654026709739427 0.0412916609258077 2.13640686218571 0.444444444444444 9.2 9 2 abnormal placenta vasculature 5.13428820284636e-06 0.000141337933668527 2.12613567534827 0.442307692307692 9.2 9 2 abnormal vasculogenesis 3.41698039436805e-05 0.000682709938232171 2.12398589205672 0.441860465116279 9.2 9 2 abnormal blood circulation 3.41698039436805e-05 0.000682709938232171 2.12398589205672 0.441860465116279 9.2 9 2 pericardial edema 2.11556231132387e-07 9.0732090507209e-06 2.12069798819905 0.441176470588235 9.2 9 2 short maxilla 0.000231775411608185 0.0031853112506926 2.12069798819905 0.441176470588235 9.2 9 2 spontaneous skin ulceration 0.00162156876638328 0.0150509414417105 2.11504279356385 0.44 9.2 9 2 increased pre-B cell number 0.00162156876638328 0.0150509414417105 2.11504279356385 0.44 9.2 9 2 abnormal keratinocyte physiology 0.00162156876638328 0.0150509414417105 2.11504279356385 0.44 9.2 9 2 diaphragmatic hernia 0.00162156876638328 0.0150509414417105 2.11504279356385 0.44 9.2 9 2 palatal shelves fail to meet at midline 6.07553758954339e-05 0.00111534315527595 2.11035311996393 0.439024390243902 9.2 9 2 increased bone trabecula number 6.07553758954339e-05 0.00111534315527595 2.11035311996393 0.439024390243902 9.2 9 2 vertebral transformation 1.61047497229715e-05 0.000360905990413438 2.10302550496405 0.4375 9.2 9 2 abnormal heart atrium morphology 0.000414564828097464 0.00514329181991243 2.10302550496405 0.4375 9.2 9 2 abnormal spongiotrophoblast layer morphology 0.000414564828097464 0.00514329181991243 2.10302550496405 0.4375 9.2 9 2 pancreatic islet hyperplasia 0.000414564828097464 0.00514329181991243 2.10302550496405 0.4375 9.2 9 2 abnormal tympanic ring morphology 0.0120255187347695 0.065242045480347 2.10302550496405 0.4375 9.2 9 2 increased pancreatic beta cell number 0.0120255187347695 0.065242045480347 2.10302550496405 0.4375 9.2 9 2 abnormal amnion morphology 0.0120255187347695 0.065242045480347 2.10302550496405 0.4375 9.2 9 2 abnormal T-helper 2 physiology 4.3040008735918e-06 0.000120294406438872 2.09756310105506 0.436363636363636 9.2 9 2 decreased circulating total protein level 4.3040008735918e-06 0.000120294406438872 2.09756310105506 0.436363636363636 9.2 9 2 cleft secondary palate 2.05092677735173e-09 1.41713343296178e-07 2.09663333017693 0.436170212765957 9.2 9 2 edema 5.42723630554322e-16 1.2111032034792e-13 2.0960387092665 0.436046511627907 9.2 9 2 abnormal cornea morphology 4.83225817099126e-08 2.4283317576446e-06 2.09532211483598 0.435897435897436 9.2 9 2 abnormal response to injury 0.000108021394156084 0.00172245652540551 2.09532211483598 0.435897435897436 9.2 9 2 perimembraneous ventricular septal defect 3.12733608941595e-07 1.27528664302003e-05 2.08996323474689 0.434782608695652 9.2 9 2 abnormal pulmonary artery morphology 0.00293047642270994 0.0239788161233256 2.08996323474689 0.434782608695652 9.2 9 2 abnormal cranial nerve morphology 0.00293047642270994 0.0239788161233256 2.08996323474689 0.434782608695652 9.2 9 2 abnormal nasal cavity morphology 0.00293047642270994 0.0239788161233256 2.08996323474689 0.434782608695652 9.2 9 2 abnormal Wolffian duct morphology 0.00293047642270994 0.0239788161233256 2.08996323474689 0.434782608695652 9.2 9 2 increased susceptibility to fungal infection 0.00293047642270994 0.0239788161233256 2.08996323474689 0.434782608695652 9.2 9 2 pallor 4.56651058078279e-16 1.08182810187592e-13 2.08757470533575 0.434285714285714 9.2 9 2 abnormal kidney development 2.03760909167449e-06 6.75807015405374e-05 2.08299669063106 0.433333333333333 9.2 9 2 increased metastatic potential 0.000741782671440851 0.00827436948524268 2.08299669063106 0.433333333333333 9.2 9 2 abnormal microglial cell physiology 0.000741782671440851 0.00827436948524268 2.08299669063106 0.433333333333333 9.2 9 2 malocclusion 0.000192041345086732 0.00276929186030867 2.07866613618069 0.432432432432432 9.2 9 2 increased trabecular bone volume 0.000192041345086732 0.00276929186030867 2.07866613618069 0.432432432432432 9.2 9 2 decreased sensitivity to induced morbidity/mortality 5.0461612570998e-05 0.000961864071037222 2.07571348541907 0.431818181818182 9.2 9 2 failure of chorioallantoic fusion 1.33990178444323e-05 0.000310047040818841 2.07357136623907 0.431372549019608 9.2 9 2 glomerulosclerosis 3.58540152681422e-06 0.000105546583407697 2.07194631030941 0.431034482758621 9.2 9 2 abnormal heart development 2.67809320789197e-14 4.16359803414455e-12 2.06879905009122 0.430379746835443 9.2 9 2 lethality throughout fetal growth and development, incomplete penetrance 5.5990700864365e-16 1.2111032034792e-13 2.06777926745069 0.430167597765363 9.2 9 2 abnormal reproductive system morphology 8.9272862668418e-05 0.00149037748917913 2.06010661710764 0.428571428571429 9.2 9 2 abnormal circulating cholesterol level 0.00132771190882873 0.0131383039140547 2.06010661710764 0.428571428571429 9.2 9 2 small superior cervical ganglion 0.00132771190882873 0.0131383039140547 2.06010661710764 0.428571428571429 9.2 9 2 abnormal hormone level 0.00132771190882873 0.0131383039140547 2.06010661710764 0.428571428571429 9.2 9 2 abnormal renal tubule epithelium morphology 0.00132771190882873 0.0131383039140547 2.06010661710764 0.428571428571429 9.2 9 2 abnormal scapula morphology 0.00530361649810967 0.0351613504044123 2.06010661710764 0.428571428571429 9.2 9 2 abnormal hematopoietic system physiology 0.00530361649810967 0.0351613504044123 2.06010661710764 0.428571428571429 9.2 9 2 liver degeneration 0.00530361649810967 0.0351613504044123 2.06010661710764 0.428571428571429 9.2 9 2 left pulmonary isomerism 0.00530361649810967 0.0351613504044123 2.06010661710764 0.428571428571429 9.2 9 2 abnormal clavicle morphology 0.00530361649810967 0.0351613504044123 2.06010661710764 0.428571428571429 9.2 9 2 abnormal tumor vascularization 0.00530361649810967 0.0351613504044123 2.06010661710764 0.428571428571429 9.2 9 2 vascular ring 0.00530361649810967 0.0351613504044123 2.06010661710764 0.428571428571429 9.2 9 2 abnormal interparietal bone morphology 0.022212054418508 0.104447042279846 2.06010661710764 0.428571428571429 9.2 9 2 midline facial cleft 0.022212054418508 0.104447042279846 2.06010661710764 0.428571428571429 9.2 9 2 absent atrioventricular cushions 0.022212054418508 0.104447042279846 2.06010661710764 0.428571428571429 9.2 9 2 megacephaly 0.022212054418508 0.104447042279846 2.06010661710764 0.428571428571429 9.2 9 2 absent visceral yolk sac blood islands 0.022212054418508 0.104447042279846 2.06010661710764 0.428571428571429 9.2 9 2 abnormal fluid regulation 0.022212054418508 0.104447042279846 2.06010661710764 0.428571428571429 9.2 9 2 intestinal obstruction 0.022212054418508 0.104447042279846 2.06010661710764 0.428571428571429 9.2 9 2 abnormal ventral body wall morphology 0.022212054418508 0.104447042279846 2.06010661710764 0.428571428571429 9.2 9 2 abnormal vascular endothelial cell migration 0.022212054418508 0.104447042279846 2.06010661710764 0.428571428571429 9.2 9 2 abnormal squamosal bone morphology 0.022212054418508 0.104447042279846 2.06010661710764 0.428571428571429 9.2 9 2 abnormal viscerocranium morphology 0.022212054418508 0.104447042279846 2.06010661710764 0.428571428571429 9.2 9 2 sternebra fusion 0.022212054418508 0.104447042279846 2.06010661710764 0.428571428571429 9.2 9 2 embryonic lethality during organogenesis, complete penetrance 5.91776467427092e-46 2.94408792544978e-42 2.05152283953636 0.426785714285714 9.2 9 2 abnormal long bone morphology 2.97083768525134e-06 9.01214480739354e-05 2.04884920389941 0.426229508196721 9.2 9 2 increased cell proliferation 1.10810704877643e-05 0.00026761323143994 2.04738990959463 0.425925925925926 9.2 9 2 abnormal osteoblast physiology 1.10810704877643e-05 0.00026761323143994 2.04738990959463 0.425925925925926 9.2 9 2 liver inflammation 7.48491080559046e-11 7.02593042600236e-09 2.04293906196508 0.425 9.2 9 2 abnormal fertility/fecundity 3.78921633930969e-07 1.48678874769253e-05 2.0412928580473 0.424657534246575 9.2 9 2 abnormal tooth development 0.000606610588439652 0.00692176072818181 2.03929745935908 0.424242424242424 9.2 9 2 enlarged pericardium 0.000606610588439652 0.00692176072818181 2.03929745935908 0.424242424242424 9.2 9 2 abnormal epidermis stratum basale morphology 0.000606610588439652 0.00692176072818181 2.03929745935908 0.424242424242424 9.2 9 2 dilated heart atrium 0.000606610588439652 0.00692176072818181 2.03929745935908 0.424242424242424 9.2 9 2 single kidney 0.000606610588439652 0.00692176072818181 2.03929745935908 0.424242424242424 9.2 9 2 liver hypoplasia 1.94598195815953e-05 0.00042092435834103 2.03369499381139 0.423076923076923 9.2 9 2 kinked neural tube 1.94598195815953e-05 0.00042092435834103 2.03369499381139 0.423076923076923 9.2 9 2 abnormal Schwann cell morphology 0.00237708469757346 0.0204956609539479 2.03369499381139 0.423076923076923 9.2 9 2 abnormal reproductive system physiology 0.000278958447256864 0.00367147691826164 2.02396439575488 0.421052631578947 9.2 9 2 kyphoscoliosis 0.00961337611666568 0.0554044657526653 2.02396439575488 0.421052631578947 9.2 9 2 flaky skin 0.00961337611666568 0.0554044657526653 2.02396439575488 0.421052631578947 9.2 9 2 unresponsive to tactile stimuli 0.00961337611666568 0.0554044657526653 2.02396439575488 0.421052631578947 9.2 9 2 increased malignant tumor incidence 0.00961337611666568 0.0554044657526653 2.02396439575488 0.421052631578947 9.2 9 2 decreased tumor incidence 0.00961337611666568 0.0554044657526653 2.02396439575488 0.421052631578947 9.2 9 2 abnormal nasal septum morphology 0.00961337611666568 0.0554044657526653 2.02396439575488 0.421052631578947 9.2 9 2 oliguria 0.00961337611666568 0.0554044657526653 2.02396439575488 0.421052631578947 9.2 9 2 abnormal sternebra morphology 0.00961337611666568 0.0554044657526653 2.02396439575488 0.421052631578947 9.2 9 2 increased circulating VLDL cholesterol level 0.00961337611666568 0.0554044657526653 2.02396439575488 0.421052631578947 9.2 9 2 small kidney 4.03014334752322e-08 2.08853782853417e-06 2.02108944632909 0.420454545454545 9.2 9 2 embryonic lethality between implantation and somite formation, complete penetrance 5.58363527529007e-20 2.13681426881293e-17 2.0208664910675 0.420408163265306 9.2 9 2 osteopetrosis 0.00107756171478917 0.011007945649027 2.0158032489978 0.419354838709677 9.2 9 2 abnormal postnatal growth/weight/body size 0.00107756171478917 0.011007945649027 2.0158032489978 0.419354838709677 9.2 9 2 preaxial polydactyly 0.00107756171478917 0.011007945649027 2.0158032489978 0.419354838709677 9.2 9 2 abnormal rostral-caudal axis patterning 1.59520892729511e-05 0.000359102462139962 2.0101646385111 0.418181818181818 9.2 9 2 decreased compact bone thickness 2.01298474717363e-06 6.72120746120054e-05 2.00886018384626 0.417910447761194 9.2 9 2 abnormal visceral yolk sac morphology 2.57322776033787e-07 1.0913949829137e-05 2.00795201920618 0.417721518987342 9.2 9 2 abnormal eye morphology 9.63401701064886e-12 1.04193988321691e-09 2.00576327708802 0.41726618705036 9.2 9 2 abnormal adrenal gland morphology 0.00425646944039726 0.031815889283931 2.0028814332991 0.416666666666667 9.2 9 2 decreased metastatic potential 0.00425646944039726 0.031815889283931 2.0028814332991 0.416666666666667 9.2 9 2 blindness 0.00425646944039726 0.031815889283931 2.0028814332991 0.416666666666667 9.2 9 2 decreased ovulation rate 0.00425646944039726 0.031815889283931 2.0028814332991 0.416666666666667 9.2 9 2 abnormal mineral level 0.0412533752433704 0.153046638207135 2.0028814332991 0.416666666666667 9.2 9 2 amyloidosis 0.0412533752433704 0.153046638207135 2.0028814332991 0.416666666666667 9.2 9 2 mesocardia 0.0412533752433704 0.153046638207135 2.0028814332991 0.416666666666667 9.2 9 2 impaired embryo implantation 0.0412533752433704 0.153046638207135 2.0028814332991 0.416666666666667 9.2 9 2 myocarditis 0.0412533752433704 0.153046638207135 2.0028814332991 0.416666666666667 9.2 9 2 increased litter size 0.0412533752433704 0.153046638207135 2.0028814332991 0.416666666666667 9.2 9 2 altered tumor susceptibility 0.0412533752433704 0.153046638207135 2.0028814332991 0.416666666666667 9.2 9 2 abnormal tracheal ciliated epithelium morphology 0.0412533752433704 0.153046638207135 2.0028814332991 0.416666666666667 9.2 9 2 abnormal respiratory function 0.0412533752433704 0.153046638207135 2.0028814332991 0.416666666666667 9.2 9 2 abnormal corticospinal tract morphology 0.0412533752433704 0.153046638207135 2.0028814332991 0.416666666666667 9.2 9 2 increased circulating parathyroid hormone level 0.0412533752433704 0.153046638207135 2.0028814332991 0.416666666666667 9.2 9 2 increased osteosarcoma incidence 0.0412533752433704 0.153046638207135 2.0028814332991 0.416666666666667 9.2 9 2 abnormal defecation 0.0412533752433704 0.153046638207135 2.0028814332991 0.416666666666667 9.2 9 2 abnormal palatine bone morphology 0.0412533752433704 0.153046638207135 2.0028814332991 0.416666666666667 9.2 9 2 decreased keratinocyte proliferation 0.0412533752433704 0.153046638207135 2.0028814332991 0.416666666666667 9.2 9 2 increased fibrosarcoma incidence 0.0412533752433704 0.153046638207135 2.0028814332991 0.416666666666667 9.2 9 2 increased skeletal muscle glycogen level 0.0412533752433704 0.153046638207135 2.0028814332991 0.416666666666667 9.2 9 2 abnormal pulmonary valve cusp morphology 0.0412533752433704 0.153046638207135 2.0028814332991 0.416666666666667 9.2 9 2 prenatal growth retardation 0.0412533752433704 0.153046638207135 2.0028814332991 0.416666666666667 9.2 9 2 atrioventricular septal defect 2.78794827320581e-05 0.000570783648526705 1.99532339015457 0.415094339622642 9.2 9 2 Leydig cell hyperplasia 0.000226636578355349 0.00313199160366073 1.99311127996593 0.414634146341463 9.2 9 2 short ulna 0.000226636578355349 0.00313199160366073 1.99311127996593 0.414634146341463 9.2 9 2 increased mortality induced by gamma-irradiation 0.00191305830388491 0.0173676369741376 1.98906845789704 0.413793103448276 9.2 9 2 abnormal embryonic erythropoiesis 0.00191305830388491 0.0173676369741376 1.98906845789704 0.413793103448276 9.2 9 2 decreased bone strength 0.00191305830388491 0.0173676369741376 1.98906845789704 0.413793103448276 9.2 9 2 abnormal blood vessel morphology 6.52062514612379e-12 7.54421165161997e-10 1.98906845789704 0.413793103448276 9.2 9 2 abnormal lymphocyte physiology 0.000104806789825097 0.00168742323423903 1.98546507300954 0.41304347826087 9.2 9 2 atrial septal defect 0.000104806789825097 0.00168742323423903 1.98546507300954 0.41304347826087 9.2 9 2 thin skin 0.00086899521222168 0.00921801957527262 1.97931812231911 0.411764705882353 9.2 9 2 abnormal dorsal-ventral axis patterning 0.0174530080140999 0.0877685584245696 1.97931812231911 0.411764705882353 9.2 9 2 decreased vasoconstriction 0.0174530080140999 0.0877685584245696 1.97931812231911 0.411764705882353 9.2 9 2 abnormal embryonic-extraembryonic boundary morphology 0.0174530080140999 0.0877685584245696 1.97931812231911 0.411764705882353 9.2 9 2 abnormal tarsal bone morphology 0.0174530080140999 0.0877685584245696 1.97931812231911 0.411764705882353 9.2 9 2 abnormal survival 0.0174530080140999 0.0877685584245696 1.97931812231911 0.411764705882353 9.2 9 2 abnormal ductus venosus valve morphology 0.0174530080140999 0.0877685584245696 1.97931812231911 0.411764705882353 9.2 9 2 perinatal lethality, incomplete penetrance 1.87839552608892e-17 5.19167652349577e-15 1.97806697306353 0.411504424778761 9.2 9 2 increased vascular permeability 0.000397871179848712 0.00498591717820489 1.9720678727868 0.41025641025641 9.2 9 2 failure of heart looping 0.000397871179848712 0.00498591717820489 1.9720678727868 0.41025641025641 9.2 9 2 increased osteoclast cell number 1.05951858802309e-05 0.000258387498794846 1.97004731144174 0.409836065573771 9.2 9 2 decreased blood urea nitrogen level 0.00018328314736662 0.00266618028698519 1.96646540723911 0.409090909090909 9.2 9 2 abnormal abdominal fat pad morphology 0.00762143901259691 0.0469847076674964 1.96646540723911 0.409090909090909 9.2 9 2 abnormal germ layer development 0.00762143901259691 0.0469847076674964 1.96646540723911 0.409090909090909 9.2 9 2 increased myocardial infarction size 0.00762143901259691 0.0469847076674964 1.96646540723911 0.409090909090909 9.2 9 2 pulmonary vascular congestion 0.00762143901259691 0.0469847076674964 1.96646540723911 0.409090909090909 9.2 9 2 increased circulating creatine kinase level 0.00762143901259691 0.0469847076674964 1.96646540723911 0.409090909090909 9.2 9 2 embryonic lethality before implantation, incomplete penetrance 0.00762143901259691 0.0469847076674964 1.96646540723911 0.409090909090909 9.2 9 2 decreased erythrocyte cell number 2.93261915391586e-12 3.74096930531575e-10 1.95950693092192 0.407643312101911 9.2 9 2 abnormal axon morphology 7.05506213702086e-09 4.28035782093644e-07 1.95837295700356 0.407407407407407 9.2 9 2 abnormal long bone epiphyseal plate proliferative zone 3.94283911500099e-05 0.00077532113032134 1.95837295700356 0.407407407407407 9.2 9 2 abnormal heart valve morphology 0.00339361168046806 0.0272309969521429 1.95837295700356 0.407407407407407 9.2 9 2 abnormal trigeminal nerve morphology 0.00339361168046806 0.0272309969521429 1.95837295700356 0.407407407407407 9.2 9 2 abnormal brain commissure morphology 0.00339361168046806 0.0272309969521429 1.95837295700356 0.407407407407407 9.2 9 2 decreased heart weight 5.15550861995858e-07 1.9430799533556e-05 1.95837295700356 0.407407407407407 9.2 9 2 abnormal osteoclast physiology 8.59421947793001e-06 0.000215940615670211 1.95280939746662 0.40625 9.2 9 2 abnormal tooth morphology 8.59421947793001e-06 0.000215940615670211 1.95280939746662 0.40625 9.2 9 2 neonatal lethality 0.00153119116357824 0.01474471177284 1.95280939746662 0.40625 9.2 9 2 microcephaly 4.02710270703207e-06 0.000116481604462119 1.95063235243043 0.405797101449275 9.2 9 2 abnormal humerus morphology 0.000697508968433098 0.00783289526248817 1.94874950266939 0.405405405405405 9.2 9 2 abnormal somite development 8.89204181213954e-07 3.13744028477973e-05 1.94710498832115 0.40506329113924 9.2 9 2 abnormal muscle morphology 0.000320043905022465 0.00415722827020043 1.94565624949055 0.404761904761905 9.2 9 2 decreased hematocrit 3.11307436805554e-11 3.16072346552577e-09 1.9425206229805 0.404109589041096 9.2 9 2 increased mean corpuscular hemoglobin 4.40626220253208e-08 2.23685249567317e-06 1.94218805653246 0.404040404040404 9.2 9 2 decreased kidney weight 6.84532623289704e-05 0.00123838174576956 1.94125431227451 0.403846153846154 9.2 9 2 abnormal lung morphology 2.21437266576582e-09 1.50911013865547e-07 1.93892387492484 0.403361344537815 9.2 9 2 prenatal lethality 1.48618308406554e-05 0.000336080038328458 1.93827235480558 0.403225806451613 9.2 9 2 rib fusion 6.95329321854646e-06 0.00018111326577104 1.93711517728032 0.402985074626866 9.2 9 2 anemia 1.97962280242631e-15 3.78793209310419e-13 1.93643512982472 0.402843601895735 9.2 9 2 increased B cell derived lymphoma incidence 0.000118639867911752 0.00186193483552356 1.92276617596713 0.4 9.2 9 2 abnormal cartilage development 0.00025660941616288 0.00342427087277303 1.92276617596713 0.4 9.2 9 2 albuminuria 0.00025660941616288 0.00342427087277303 1.92276617596713 0.4 9.2 9 2 abnormal cell migration 0.00025660941616288 0.00342427087277303 1.92276617596713 0.4 9.2 9 2 small placenta 0.00025660941616288 0.00342427087277303 1.92276617596713 0.4 9.2 9 2 abnormal primitive streak morphology 0.00601306988973992 0.0389518524758543 1.92276617596713 0.4 9.2 9 2 abnormal vertebrae development 0.00601306988973992 0.0389518524758543 1.92276617596713 0.4 9.2 9 2 abnormal preimplantation embryo development 0.00601306988973992 0.0389518524758543 1.92276617596713 0.4 9.2 9 2 abnormal neurocranium morphology 2.63395836121664e-06 8.29363471332454e-05 1.92276617596713 0.4 9.2 9 2 abnormal eating behavior 2.56581384381767e-05 0.000538604382826705 1.92276617596713 0.4 9.2 9 2 emphysema 0.00269390872551429 0.0227155862871756 1.92276617596713 0.4 9.2 9 2 abnormal fontanelle morphology 0.0317345774311727 0.130911710381496 1.92276617596713 0.4 9.2 9 2 decreased chondrocyte number 0.0317345774311727 0.130911710381496 1.92276617596713 0.4 9.2 9 2 decreased hepatocyte number 0.0317345774311727 0.130911710381496 1.92276617596713 0.4 9.2 9 2 no suckling reflex 0.0317345774311727 0.130911710381496 1.92276617596713 0.4 9.2 9 2 abnormal apical ectodermal ridge morphology 0.0317345774311727 0.130911710381496 1.92276617596713 0.4 9.2 9 2 abnormal cricoid cartilage morphology 0.0317345774311727 0.130911710381496 1.92276617596713 0.4 9.2 9 2 abnormal bronchus morphology 0.0317345774311727 0.130911710381496 1.92276617596713 0.4 9.2 9 2 joint inflammation 0.0317345774311727 0.130911710381496 1.92276617596713 0.4 9.2 9 2 immune system phenotype 0.0317345774311727 0.130911710381496 1.92276617596713 0.4 9.2 9 2 abnormal neurotransmitter secretion 0.0317345774311727 0.130911710381496 1.92276617596713 0.4 9.2 9 2 decreased thymocyte apoptosis 0.0317345774311727 0.130911710381496 1.92276617596713 0.4 9.2 9 2 absent chorion 0.0317345774311727 0.130911710381496 1.92276617596713 0.4 9.2 9 2 liver vascular congestion 0.0317345774311727 0.130911710381496 1.92276617596713 0.4 9.2 9 2 ostium primum atrial septal defect 0.0317345774311727 0.130911710381496 1.92276617596713 0.4 9.2 9 2 heterochrony 0.0317345774311727 0.130911710381496 1.92276617596713 0.4 9.2 9 2 abnormal circulating enzyme level 0.0136418862241214 0.0732919913228982 1.92276617596713 0.4 9.2 9 2 abnormal dopamine level 0.0136418862241214 0.0732919913228982 1.92276617596713 0.4 9.2 9 2 abnormal hyoid bone morphology 0.0136418862241214 0.0732919913228982 1.92276617596713 0.4 9.2 9 2 increased skin tumor incidence 0.0136418862241214 0.0732919913228982 1.92276617596713 0.4 9.2 9 2 decreased bone mineral density 1.82555016069424e-18 5.67632003090865e-16 1.91553773169658 0.398496240601504 9.2 9 2 short snout 2.3438009814692e-08 1.28136372338563e-06 1.91386448070803 0.398148148148148 9.2 9 2 polydactyly 1.04835034099804e-07 4.92032353440119e-06 1.9129561444571 0.397959183673469 9.2 9 2 decreased bone marrow cell number 4.52256848575227e-06 0.000125697085009036 1.90959654462489 0.397260273972603 9.2 9 2 decreased circulating alanine transaminase level 9.64789433800682e-06 0.000236444701140807 1.90862818937914 0.397058823529412 9.2 9 2 decreased susceptibility to hepatic steatosis 2.0627336958938e-05 0.000442331902459986 1.90750612695152 0.396825396825397 9.2 9 2 small spleen 3.79542052174776e-07 1.48678874769253e-05 1.90163687733013 0.395604395604396 9.2 9 2 decreased hair follicle number 0.000970476699634991 0.0100795857634323 1.8974666210202 0.394736842105263 9.2 9 2 abnormal skeletal muscle fiber morphology 7.7517411446009e-06 0.000198788207187575 1.89568496222112 0.394366197183099 9.2 9 2 abnormal ovarian folliculogenesis 0.00213216853741833 0.0191818055581486 1.89363335511915 0.393939393939394 9.2 9 2 abnormal muscle physiology 6.47791386166186e-07 2.35238112859619e-05 1.89036000446207 0.393258426966292 9.2 9 2 rib bifurcation 0.00473037035623469 0.0346591936999523 1.88843106568201 0.392857142857143 9.2 9 2 abnormal jaw morphology 0.00473037035623469 0.0346591936999523 1.88843106568201 0.392857142857143 9.2 9 2 lymphoid hyperplasia 0.00473037035623469 0.0346591936999523 1.88843106568201 0.392857142857143 9.2 9 2 abnormal somite shape 0.00473037035623469 0.0346591936999523 1.88843106568201 0.392857142857143 9.2 9 2 increased triglyceride level 0.00473037035623469 0.0346591936999523 1.88843106568201 0.392857142857143 9.2 9 2 subcutaneous edema 0.00473037035623469 0.0346591936999523 1.88843106568201 0.392857142857143 9.2 9 2 abnormal placenta morphology 2.9215331199194e-06 8.91694924637975e-05 1.88625795743611 0.392405063291139 9.2 9 2 abnormal placenta labyrinth morphology 2.9215331199194e-06 8.91694924637975e-05 1.88625795743611 0.392405063291139 9.2 9 2 abnormal extraembryonic tissue morphology 1.16161726535926e-07 5.40097747211432e-06 1.88506487839915 0.392156862745098 9.2 9 2 abnormal trophoblast layer morphology 0.000163783364040778 0.00241071667486056 1.88506487839915 0.392156862745098 9.2 9 2 prenatal lethality, incomplete penetrance 8.30065171640141e-20 2.94969587779264e-17 1.88165439917836 0.391447368421053 9.2 9 2 fragile skeleton 0.0106370578203814 0.0584744338744724 1.8809669112722 0.391304347826087 9.2 9 2 abnormal blood vessel physiology 0.0106370578203814 0.0584744338744724 1.8809669112722 0.391304347826087 9.2 9 2 abnormal innervation pattern to muscle 0.0106370578203814 0.0584744338744724 1.8809669112722 0.391304347826087 9.2 9 2 hypotension 0.0106370578203814 0.0584744338744724 1.8809669112722 0.391304347826087 9.2 9 2 abnormal postnatal growth 0.0106370578203814 0.0584744338744724 1.8809669112722 0.391304347826087 9.2 9 2 dilated heart 0.0106370578203814 0.0584744338744724 1.8809669112722 0.391304347826087 9.2 9 2 abnormal corneal stroma morphology 0.0106370578203814 0.0584744338744724 1.8809669112722 0.391304347826087 9.2 9 2 abnormal basicranium morphology 0.0106370578203814 0.0584744338744724 1.8809669112722 0.391304347826087 9.2 9 2 abnormal vertebral artery topology 0.0106370578203814 0.0584744338744724 1.8809669112722 0.391304347826087 9.2 9 2 liver fibrosis 0.000769877300885702 0.00843361448137447 1.87586943996794 0.390243902439024 9.2 9 2 increased B cell proliferation 6.07220205775323e-05 0.00111534315527595 1.87388229013746 0.389830508474576 9.2 9 2 perinatal lethality, complete penetrance 3.88678171889704e-14 5.68727619162141e-12 1.87311728409944 0.389671361502347 9.2 9 2 increased inflammatory response 4.17848911108697e-07 1.62406119747326e-05 1.87216706607326 0.389473684210526 9.2 9 2 decreased embryo size 8.64631105427786e-30 7.16923291583873e-27 1.87047337201824 0.389121338912134 9.2 9 2 abnormal chondrocyte morphology 0.000130494341396357 0.00199756722599039 1.86935600441249 0.388888888888889 9.2 9 2 abnormal pharyngeal arch morphology 0.00168413143716042 0.0155735202599872 1.86935600441249 0.388888888888889 9.2 9 2 narrow eye opening 0.00168413143716042 0.0155735202599872 1.86935600441249 0.388888888888889 9.2 9 2 lowered ear position 0.0243974795065489 0.112909265623331 1.86935600441249 0.388888888888889 9.2 9 2 abnormal megakaryocyte differentiation 0.0243974795065489 0.112909265623331 1.86935600441249 0.388888888888889 9.2 9 2 delayed kidney development 0.0243974795065489 0.112909265623331 1.86935600441249 0.388888888888889 9.2 9 2 abnormal thymus cortex morphology 0.0243974795065489 0.112909265623331 1.86935600441249 0.388888888888889 9.2 9 2 abnormal thymus medulla morphology 0.0243974795065489 0.112909265623331 1.86935600441249 0.388888888888889 9.2 9 2 decreased activity of thyroid 0.0243974795065489 0.112909265623331 1.86935600441249 0.388888888888889 9.2 9 2 absent ureter 0.0243974795065489 0.112909265623331 1.86935600441249 0.388888888888889 9.2 9 2 long tibia 0.0243974795065489 0.112909265623331 1.86935600441249 0.388888888888889 9.2 9 2 jerky movement 0.0243974795065489 0.112909265623331 1.86935600441249 0.388888888888889 9.2 9 2 increased gastrointestinal tumor incidence 0.0243974795065489 0.112909265623331 1.86935600441249 0.388888888888889 9.2 9 2 decreased tumor latency 0.0243974795065489 0.112909265623331 1.86935600441249 0.388888888888889 9.2 9 2 internal hemorrhage 2.26395226032733e-05 0.000481242551002803 1.86537017071438 0.388059701492537 9.2 9 2 abnormal embryonic tissue morphology 4.44180457421529e-10 3.51935633210042e-08 1.86390598690692 0.387755102040816 9.2 9 2 absent kidney 0.000281459426297853 0.00369461911828977 1.86390598690692 0.387755102040816 9.2 9 2 respiratory distress 1.47028020097879e-11 1.55630723401478e-09 1.86163777152887 0.38728323699422 9.2 9 2 abnormal podocyte morphology 0.00371475946913014 0.0291320853797608 1.86074146061336 0.387096774193548 9.2 9 2 abnormal limb morphology 8.47854606460357e-06 0.000215207993221443 1.85867397010156 0.386666666666667 9.2 9 2 osteoporosis 0.000609771385446845 0.00694190536063628 1.85721732905916 0.386363636363636 9.2 9 2 incomplete embryo turning 0.000103828688872402 0.00168256588645016 1.85530069610864 0.385964912280702 9.2 9 2 abnormal craniofacial bone morphology 0.000103828688872402 0.00168256588645016 1.85530069610864 0.385964912280702 9.2 9 2 abnormal neural tube closure 3.18661881517626e-06 9.55025819608548e-05 1.85326860334182 0.385542168674699 9.2 9 2 abnormal renal glomerulus morphology 1.01775099210754e-07 4.82220112927145e-06 1.85220594932614 0.385321100917431 9.2 9 2 prenatal lethality, complete penetrance 2.432021768398e-17 6.36805699883161e-15 1.85014371248636 0.384892086330935 9.2 9 2 neonatal lethality, incomplete penetrance 2.79981781039286e-16 6.96454680335225e-14 1.84881363073763 0.384615384615385 9.2 9 2 increased grip strength 1.20117365207644e-06 4.1789083350212e-05 1.84881363073763 0.384615384615385 9.2 9 2 distended pericardium 0.000223364677610657 0.00310402031037157 1.84881363073763 0.384615384615385 9.2 9 2 eyelids open at birth 0.000223364677610657 0.00310402031037157 1.84881363073763 0.384615384615385 9.2 9 2 increased hepatocyte apoptosis 0.00132835514950141 0.0131383039140547 1.84881363073763 0.384615384615385 9.2 9 2 abnormal nasal bone morphology 0.00828556063484395 0.0500250778620736 1.84881363073763 0.384615384615385 9.2 9 2 abnormal kidney cortex morphology 0.00828556063484395 0.0500250778620736 1.84881363073763 0.384615384615385 9.2 9 2 small seminal vesicle 0.00828556063484395 0.0500250778620736 1.84881363073763 0.384615384615385 9.2 9 2 abnormal Mullerian duct morphology 0.00828556063484395 0.0500250778620736 1.84881363073763 0.384615384615385 9.2 9 2 increased thymocyte apoptosis 0.00828556063484395 0.0500250778620736 1.84881363073763 0.384615384615385 9.2 9 2 absent teeth 0.0577755630486154 0.198725625467709 1.84881363073763 0.384615384615385 9.2 9 2 absent common myeloid progenitor cells 0.0577755630486154 0.198725625467709 1.84881363073763 0.384615384615385 9.2 9 2 short hair 0.0577755630486154 0.198725625467709 1.84881363073763 0.384615384615385 9.2 9 2 abnormal renal/urinary system morphology 0.0577755630486154 0.198725625467709 1.84881363073763 0.384615384615385 9.2 9 2 abnormal grip strength 0.0577755630486154 0.198725625467709 1.84881363073763 0.384615384615385 9.2 9 2 increased pituitary adenoma incidence 0.0577755630486154 0.198725625467709 1.84881363073763 0.384615384615385 9.2 9 2 abnormal coping response 0.0577755630486154 0.198725625467709 1.84881363073763 0.384615384615385 9.2 9 2 abnormal soleus morphology 0.0577755630486154 0.198725625467709 1.84881363073763 0.384615384615385 9.2 9 2 axonal dystrophy 0.0577755630486154 0.198725625467709 1.84881363073763 0.384615384615385 9.2 9 2 abnormal dopaminergic neuron morphology 0.0577755630486154 0.198725625467709 1.84881363073763 0.384615384615385 9.2 9 2 small interparietal bone 0.0577755630486154 0.198725625467709 1.84881363073763 0.384615384615385 9.2 9 2 hyperalgesia 0.0577755630486154 0.198725625467709 1.84881363073763 0.384615384615385 9.2 9 2 increased circulating thyroxine level 0.0577755630486154 0.198725625467709 1.84881363073763 0.384615384615385 9.2 9 2 increased renin activity 0.0577755630486154 0.198725625467709 1.84881363073763 0.384615384615385 9.2 9 2 increased prostaglandin level 0.0577755630486154 0.198725625467709 1.84881363073763 0.384615384615385 9.2 9 2 decreased circulating serum albumin level 4.53862945006087e-07 1.73689857800406e-05 1.84507865370584 0.383838383838384 9.2 9 2 seminiferous tubule degeneration 1.43976419052087e-05 0.000328570038891804 1.84374838791369 0.383561643835616 9.2 9 2 absent mesoderm 8.25184878533484e-05 0.00140112449512085 1.84265091863517 0.383333333333333 9.2 9 2 embryonic lethality during organogenesis, incomplete penetrance 2.37913560548135e-14 3.93129462252205e-12 1.83916764657726 0.382608695652174 9.2 9 2 abnormal cell cycle 6.51654175926356e-08 3.17841129924865e-06 1.83916764657726 0.382608695652174 9.2 9 2 decreased mean corpuscular hemoglobin 3.06819591484382e-05 0.000617986829001943 1.83793825643917 0.382352941176471 9.2 9 2 overexpanded pulmonary alveoli 0.00291413297682577 0.0239788161233256 1.83793825643917 0.382352941176471 9.2 9 2 increased width of hypertrophic chondrocyte zone 0.00291413297682577 0.0239788161233256 1.83793825643917 0.382352941176471 9.2 9 2 decreased regulatory T cell number 0.00291413297682577 0.0239788161233256 1.83793825643917 0.382352941176471 9.2 9 2 abnormal head morphology 0.000177074245187372 0.00259865595813326 1.83536771342317 0.381818181818182 9.2 9 2 hydronephrosis 4.30161986749607e-06 0.000120294406438872 1.83120588187346 0.380952380952381 9.2 9 2 decreased inflammatory response 4.30161986749607e-06 0.000120294406438872 1.83120588187346 0.380952380952381 9.2 9 2 skin edema 0.00104669785218615 0.0108260328786406 1.83120588187346 0.380952380952381 9.2 9 2 abnormal cytotoxic T cell physiology 0.00104669785218615 0.0108260328786406 1.83120588187346 0.380952380952381 9.2 9 2 abnormal erythrocyte physiology 0.0187731291324362 0.0913858291916538 1.83120588187346 0.380952380952381 9.2 9 2 embryonic lethality at implantation, complete penetrance 0.0187731291324362 0.0913858291916538 1.83120588187346 0.380952380952381 9.2 9 2 absent segment of posterior cerebral artery 0.0187731291324362 0.0913858291916538 1.83120588187346 0.380952380952381 9.2 9 2 increased bone ossification 0.0187731291324362 0.0913858291916538 1.83120588187346 0.380952380952381 9.2 9 2 abnormal cranium morphology 7.52308869360773e-09 4.50932123502391e-07 1.82949766743142 0.380597014925373 9.2 9 2 abnormal bone mineralization 4.16142413359877e-08 2.13433866645916e-06 1.82742239864645 0.380165289256198 9.2 9 2 abnormal nervous system morphology 9.12335199395105e-06 0.000224696416682705 1.82541092655108 0.379746835443038 9.2 9 2 decreased B cell proliferation 9.12335199395105e-06 0.000224696416682705 1.82541092655108 0.379746835443038 9.2 9 2 abnormal myocardium layer morphology 9.12335199395105e-06 0.000224696416682705 1.82541092655108 0.379746835443038 9.2 9 2 abnormal parietal bone morphology 0.0064520610548929 0.0412916609258077 1.82331275307228 0.379310344827586 9.2 9 2 lordosis 0.0064520610548929 0.0412916609258077 1.82331275307228 0.379310344827586 9.2 9 2 abnormal spinal nerve morphology 0.0064520610548929 0.0412916609258077 1.82331275307228 0.379310344827586 9.2 9 2 short sternum 0.0064520610548929 0.0412916609258077 1.82331275307228 0.379310344827586 9.2 9 2 blood in lymph vessels 0.0064520610548929 0.0412916609258077 1.82331275307228 0.379310344827586 9.2 9 2 abnormal craniofacial morphology 4.87107917792223e-07 1.84989457329489e-05 1.82009419569705 0.378640776699029 9.2 9 2 increased granulocyte number 1.93761655227219e-05 0.00042092435834103 1.8188328691581 0.378378378378378 9.2 9 2 abnormal intestine morphology 1.93761655227219e-05 0.00042092435834103 1.8188328691581 0.378378378378378 9.2 9 2 impaired skeletal muscle contractility 0.00228468424421184 0.0202493571169767 1.8188328691581 0.378378378378378 9.2 9 2 abnormal bone structure 7.04787677091685e-12 7.79181931895808e-10 1.81815972597929 0.378238341968912 9.2 9 2 thin ventricular wall 2.72606287773628e-06 8.47635176046124e-05 1.81594583285785 0.377777777777778 9.2 9 2 altered response to myocardial infarction 0.000824191152512108 0.00889447068058077 1.81594583285785 0.377777777777778 9.2 9 2 decreased birth body size 1.46906866110381e-07 6.64419689908315e-06 1.81313477119708 0.37719298245614 9.2 9 2 increased double-negative T cell number 0.000111020200186439 0.00176461819785154 1.8124435265264 0.377049180327869 9.2 9 2 abnormal definitive hematopoiesis 2.16821334870087e-06 7.05023621554694e-05 1.80905419781854 0.376344086021505 9.2 9 2 abnormal cardiovascular system physiology 1.68607046011915e-08 9.64160981504919e-07 1.80711106763828 0.37593984962406 9.2 9 2 decreased hemoglobin content 6.41086578617306e-09 4.03722244129253e-07 1.80685473982727 0.375886524822695 9.2 9 2 abnormal osteoclast morphology 0.000648675794409588 0.00731782783942789 1.80259328996919 0.375 9.2 9 2 failure of primitive streak formation 0.00502490045246128 0.0351613504044123 1.80259328996919 0.375 9.2 9 2 abnormal diaphragm morphology 0.00502490045246128 0.0351613504044123 1.80259328996919 0.375 9.2 9 2 bradykinesia 0.00502490045246128 0.0351613504044123 1.80259328996919 0.375 9.2 9 2 abnormal digestive system morphology 0.0144654108483719 0.0768040757424227 1.80259328996919 0.375 9.2 9 2 abnormal cardiac muscle contractility 0.0144654108483719 0.0768040757424227 1.80259328996919 0.375 9.2 9 2 abnormal tumor morphology 0.0144654108483719 0.0768040757424227 1.80259328996919 0.375 9.2 9 2 abnormal lung saccule morphology 0.0144654108483719 0.0768040757424227 1.80259328996919 0.375 9.2 9 2 vasculature congestion 0.0435600126490146 0.158530404483429 1.80259328996919 0.375 9.2 9 2 decreased mast cell number 0.0435600126490146 0.158530404483429 1.80259328996919 0.375 9.2 9 2 abnormal mouth morphology 0.0435600126490146 0.158530404483429 1.80259328996919 0.375 9.2 9 2 abnormal olfaction 0.0435600126490146 0.158530404483429 1.80259328996919 0.375 9.2 9 2 increased intestinal adenocarcinoma incidence 0.0435600126490146 0.158530404483429 1.80259328996919 0.375 9.2 9 2 large intestinal inflammation 0.0435600126490146 0.158530404483429 1.80259328996919 0.375 9.2 9 2 abnormal Langerhans cell physiology 0.0435600126490146 0.158530404483429 1.80259328996919 0.375 9.2 9 2 decreased circulating triiodothyronine level 0.0435600126490146 0.158530404483429 1.80259328996919 0.375 9.2 9 2 decreased creatinine clearance 0.0435600126490146 0.158530404483429 1.80259328996919 0.375 9.2 9 2 impaired somite development 0.0435600126490146 0.158530404483429 1.80259328996919 0.375 9.2 9 2 decreased liver cholesterol level 0.0435600126490146 0.158530404483429 1.80259328996919 0.375 9.2 9 2 abnormal thoracic cage shape 0.0435600126490146 0.158530404483429 1.80259328996919 0.375 9.2 9 2 abnormal seminal vesicle morphology 0.000237691010441879 0.00324866147513282 1.80259328996919 0.375 9.2 9 2 distended abdomen 0.000510374096404254 0.00607442853973963 1.79081163447919 0.372549019607843 9.2 9 2 abnormal organ of Corti morphology 0.00140326437856856 0.0136887064379972 1.78861969857408 0.372093023255814 9.2 9 2 abnormal heart ventricle morphology 2.04808454663992e-05 0.000441091801711411 1.78718650971304 0.371794871794872 9.2 9 2 abnormal liver development 0.00391476596129855 0.029825360884319 1.78542573482662 0.371428571428571 9.2 9 2 increased red blood cell distribution width 0.00391476596129855 0.029825360884319 1.78542573482662 0.371428571428571 9.2 9 2 abnormal type II pneumocyte morphology 0.0111631776668297 0.0612313218219162 1.78033905182142 0.37037037037037 9.2 9 2 abnormal palate morphology 0.0111631776668297 0.0612313218219162 1.78033905182142 0.37037037037037 9.2 9 2 abnormal cell death 0.00109970507226934 0.0111882060011042 1.77646874953485 0.369565217391304 9.2 9 2 abnormal cell morphology 4.31481028223783e-07 1.664045050708e-05 1.77096884628552 0.368421052631579 9.2 9 2 increased hepatocellular carcinoma incidence 0.000315777364690739 0.0041125455218231 1.77096884628552 0.368421052631579 9.2 9 2 persistence of hyaloid vascular system 0.00305130531188167 0.02488564578133 1.77096884628552 0.368421052631579 9.2 9 2 irregular coat pigmentation 0.0330215398173141 0.134327195904446 1.77096884628552 0.368421052631579 9.2 9 2 small superior vagus ganglion 0.0330215398173141 0.134327195904446 1.77096884628552 0.368421052631579 9.2 9 2 abnormal stationary movement 0.0330215398173141 0.134327195904446 1.77096884628552 0.368421052631579 9.2 9 2 delayed sexual maturation 0.0330215398173141 0.134327195904446 1.77096884628552 0.368421052631579 9.2 9 2 abnormal digestive system development 0.0330215398173141 0.134327195904446 1.77096884628552 0.368421052631579 9.2 9 2 absent amnion 0.0330215398173141 0.134327195904446 1.77096884628552 0.368421052631579 9.2 9 2 decreased susceptibility to weight gain 0.0330215398173141 0.134327195904446 1.77096884628552 0.368421052631579 9.2 9 2 decreased liver glycogen level 0.0330215398173141 0.134327195904446 1.77096884628552 0.368421052631579 9.2 9 2 abnormal heart morphology 8.12077809253764e-13 1.06318081606249e-10 1.76877840862778 0.367965367965368 9.2 9 2 extramedullary hematopoiesis 1.14055307052823e-06 3.9959517787873e-05 1.76858209581883 0.367924528301887 9.2 9 2 abnormal long bone hypertrophic chondrocyte zone 0.000861898201700265 0.00916227255012568 1.76580567180655 0.36734693877551 9.2 9 2 increased T cell derived lymphoma incidence 0.000861898201700265 0.00916227255012568 1.76580567180655 0.36734693877551 9.2 9 2 abnormal incisor morphology 0.000248357317139906 0.0033575479694865 1.76253566130321 0.366666666666667 9.2 9 2 abnormal pain threshold 0.00862783345611211 0.0519026256882197 1.76253566130321 0.366666666666667 9.2 9 2 liver hemorrhage 0.00862783345611211 0.0519026256882197 1.76253566130321 0.366666666666667 9.2 9 2 postnatal lethality, incomplete penetrance 5.90548477157145e-29 4.197112391224e-26 1.76027889349104 0.366197183098592 9.2 9 2 corneal opacity 7.25210510244118e-05 0.00128870853490689 1.76027889349104 0.366197183098592 9.2 9 2 lethargy 6.3446237422819e-06 0.000168794134320067 1.75736693502373 0.365591397849462 9.2 9 2 gliosis 0.000195330091848284 0.00280602036283514 1.7549056367954 0.365079365079365 9.2 9 2 decreased body length 1.4986667976651e-14 2.5709887304772e-12 1.75434870069994 0.364963503649635 9.2 9 2 pale liver 5.71682429541798e-05 0.00107731821476153 1.75387455240245 0.364864864864865 9.2 9 2 abnormal neural tube morphology 3.71896586192193e-09 2.43445462671863e-07 1.75066673429106 0.364197530864198 9.2 9 2 renal interstitial fibrosis 0.00185668894606667 0.0170111003806293 1.74796925087921 0.363636363636364 9.2 9 2 belly spot 0.00667789011820012 0.0418306673095963 1.74796925087921 0.363636363636364 9.2 9 2 abnormal locomotor coordination 0.00667789011820012 0.0418306673095963 1.74796925087921 0.363636363636364 9.2 9 2 increased osteoblast cell number 0.00667789011820012 0.0418306673095963 1.74796925087921 0.363636363636364 9.2 9 2 abnormal enterocyte morphology 0.02514552348663 0.115511522941814 1.74796925087921 0.363636363636364 9.2 9 2 testis hypoplasia 0.02514552348663 0.115511522941814 1.74796925087921 0.363636363636364 9.2 9 2 abnormal circulating lipid level 0.02514552348663 0.115511522941814 1.74796925087921 0.363636363636364 9.2 9 2 abnormal cerebral cortex pyramidal cell morphology 0.02514552348663 0.115511522941814 1.74796925087921 0.363636363636364 9.2 9 2 increased adenoma incidence 0.02514552348663 0.115511522941814 1.74796925087921 0.363636363636364 9.2 9 2 increased tumor incidence 2.81538369941912e-07 1.17701965584959e-05 1.74444511932502 0.362903225806452 9.2 9 2 kinked tail 3.13399611447035e-06 9.44947313302425e-05 1.74368501251922 0.362745098039216 9.2 9 2 abnormal sternum morphology 0.000120836901140154 0.00189045151940964 1.74163602895574 0.36231884057971 9.2 9 2 decreased cell proliferation 4.45667234014727e-10 3.51935633210042e-08 1.74088288905132 0.362162162162162 9.2 9 2 abnormal trabecular bone morphology 5.86678572165678e-07 2.16201918261056e-05 1.7369526379535 0.361344537815126 9.2 9 2 abnormal neuromuscular synapse morphology 9.50511990645453e-05 0.00157626571782038 1.73583057552589 0.361111111111111 9.2 9 2 heart right ventricle hypertrophy 0.00517555938798533 0.0351613504044123 1.73583057552589 0.361111111111111 9.2 9 2 abnormal retinal blood vessel morphology 0.00517555938798533 0.0351613504044123 1.73583057552589 0.361111111111111 9.2 9 2 kidney inflammation 0.00113226165704958 0.0114725086432213 1.73048955837042 0.36 9.2 9 2 abnormal axon extension 0.00113226165704958 0.0114725086432213 1.73048955837042 0.36 9.2 9 2 kyphosis 2.63843503188677e-08 1.42676242213442e-06 1.73048955837042 0.36 9.2 9 2 abnormal kidney morphology 1.91332054416405e-09 1.35982424388802e-07 1.73048955837042 0.36 9.2 9 2 cyanosis 3.64046205294008e-10 2.96906536284867e-08 1.72748523622047 0.359375 9.2 9 2 increased urine protein level 5.88288537154037e-05 0.00110442848012881 1.72555938868845 0.358974358974359 9.2 9 2 abnormal iris morphology 0.0040161574028146 0.030457901035065 1.72555938868845 0.358974358974359 9.2 9 2 increased leukocyte cell number 5.47037577547077e-08 2.72151194829671e-06 1.72385933017743 0.358620689655172 9.2 9 2 increased circulating bilirubin level 0.000884906305663324 0.00930741833123686 1.72323383695168 0.358490566037736 9.2 9 2 abnormal femur morphology 0.000200612821570185 0.00284344383849479 1.72188015758251 0.358208955223881 9.2 9 2 decreased leukocyte cell number 1.43375567334852e-07 6.5439765824852e-06 1.71926172668594 0.357664233576642 9.2 9 2 respiratory failure 3.42277901238614e-08 1.81152399857671e-06 1.71902936261962 0.357615894039735 9.2 9 2 abnormal liver morphology 1.96448898147437e-09 1.37652572997676e-07 1.71867367684213 0.357541899441341 9.2 9 2 neonatal lethality, complete penetrance 1.00666462757566e-21 5.00815652218893e-19 1.71826144014607 0.357456140350877 9.2 9 2 shortened head 0.0147369595060492 0.0778446957824884 1.71675551425637 0.357142857142857 9.2 9 2 hypoxia 0.0147369595060492 0.0778446957824884 1.71675551425637 0.357142857142857 9.2 9 2 abnormal blood flow velocity 0.0775330678431195 0.234164173588701 1.71675551425637 0.357142857142857 9.2 9 2 increased aggression towards males 0.0775330678431195 0.234164173588701 1.71675551425637 0.357142857142857 9.2 9 2 abnormal adrenal gland secretion 0.0775330678431195 0.234164173588701 1.71675551425637 0.357142857142857 9.2 9 2 abnormal endplate potential 0.0775330678431195 0.234164173588701 1.71675551425637 0.357142857142857 9.2 9 2 increased lactate dehydrogenase level 0.0775330678431195 0.234164173588701 1.71675551425637 0.357142857142857 9.2 9 2 decreased vascular permeability 0.0775330678431195 0.234164173588701 1.71675551425637 0.357142857142857 9.2 9 2 amyloid beta deposits 0.0775330678431195 0.234164173588701 1.71675551425637 0.357142857142857 9.2 9 2 skeletal muscle necrosis 0.0775330678431195 0.234164173588701 1.71675551425637 0.357142857142857 9.2 9 2 abnormal maternal decidual layer morphology 0.0775330678431195 0.234164173588701 1.71675551425637 0.357142857142857 9.2 9 2 abnormal positive T cell selection 0.0775330678431195 0.234164173588701 1.71675551425637 0.357142857142857 9.2 9 2 increased circulating growth hormone level 0.0775330678431195 0.234164173588701 1.71675551425637 0.357142857142857 9.2 9 2 increased pulmonary respiratory rate 0.0775330678431195 0.234164173588701 1.71675551425637 0.357142857142857 9.2 9 2 increased stomach tumor incidence 0.0775330678431195 0.234164173588701 1.71675551425637 0.357142857142857 9.2 9 2 increased lung compliance 0.0775330678431195 0.234164173588701 1.71675551425637 0.357142857142857 9.2 9 2 multiple persisting craniopharyngeal ducts 0.0775330678431195 0.234164173588701 1.71675551425637 0.357142857142857 9.2 9 2 abnormal vitelline vein topology 0.0775330678431195 0.234164173588701 1.71675551425637 0.357142857142857 9.2 9 2 decreased bone mineral content 1.46548128826611e-10 1.35014248317109e-08 1.71015260843231 0.355769230769231 9.2 9 2 abnormal axial skeleton morphology 9.70931603788399e-05 0.00160477897968348 1.70771995891818 0.355263157894737 9.2 9 2 thymus hypoplasia 1.85352652947416e-07 8.16043759657871e-06 1.70680330837662 0.355072463768116 9.2 9 2 impaired glucose tolerance 3.32859423409662e-12 4.13993907865767e-10 1.70567967222891 0.354838709677419 9.2 9 2 decreased double-negative T cell number 0.0113300241489522 0.0617380833965358 1.70567967222891 0.354838709677419 9.2 9 2 abnormal response/metabolism to endogenous compounds 5.99196328257662e-05 0.00111534315527595 1.70000667997094 0.353658536585366 9.2 9 2 decreased total body fat amount 1.07182373107852e-15 2.13292922484626e-13 1.6982515626057 0.353293413173653 9.2 9 2 abnormal thrombosis 0.0014714730537652 0.014232478330284 1.69655839055924 0.352941176470588 9.2 9 2 decreased osteoblast cell number 0.00873084855894973 0.0523956231372436 1.69655839055924 0.352941176470588 9.2 9 2 increased susceptibility to viral infection induced morbidity/mortality 0.00873084855894973 0.0523956231372436 1.69655839055924 0.352941176470588 9.2 9 2 abnormal vagus nerve morphology 0.0578001969953317 0.198725625467709 1.69655839055924 0.352941176470588 9.2 9 2 absence seizures 0.0578001969953317 0.198725625467709 1.69655839055924 0.352941176470588 9.2 9 2 abnormal testis development 0.0578001969953317 0.198725625467709 1.69655839055924 0.352941176470588 9.2 9 2 increased regulatory T cell number 0.0578001969953317 0.198725625467709 1.69655839055924 0.352941176470588 9.2 9 2 increased circulating magnesium level 0.0578001969953317 0.198725625467709 1.69655839055924 0.352941176470588 9.2 9 2 common atrium 0.0578001969953317 0.198725625467709 1.69655839055924 0.352941176470588 9.2 9 2 abnormal ovary morphology 0.000203638998695485 0.00286998305526923 1.692575859126 0.352112676056338 9.2 9 2 atelectasis 0.000203638998695485 0.00286998305526923 1.692575859126 0.352112676056338 9.2 9 2 preweaning lethality, incomplete penetrance 1.11459728028765e-18 3.69674764628737e-16 1.69241032603464 0.352078239608802 9.2 9 2 abnormal small intestine morphology 0.00114733932905564 0.0115596559433449 1.69132209923035 0.351851851851852 9.2 9 2 impaired limb coordination 0.00114733932905564 0.0115596559433449 1.69132209923035 0.351851851851852 9.2 9 2 increased circulating phosphate level 0.00674145009086265 0.0420284639123329 1.68891623564681 0.351351351351351 9.2 9 2 increased erythroid progenitor cell number 0.00674145009086265 0.0420284639123329 1.68891623564681 0.351351351351351 9.2 9 2 abnormal pancreatic beta cell physiology 0.00674145009086265 0.0420284639123329 1.68891623564681 0.351351351351351 9.2 9 2 abnormal facial morphology 0.000895268780299864 0.00937114774848417 1.6866369964624 0.350877192982456 9.2 9 2 decreased double-positive T cell number 1.41514914010201e-05 0.000324440874286061 1.68242040397124 0.35 9.2 9 2 abnormal long bone epiphyseal plate morphology 0.000699056381215025 0.00783289526248817 1.68242040397124 0.35 9.2 9 2 perinatal lethality 0.00521451309627655 0.0351613504044123 1.68242040397124 0.35 9.2 9 2 abnormal basioccipital bone morphology 0.0434567379059563 0.158530404483429 1.68242040397124 0.35 9.2 9 2 abnormal vascular regression 0.0434567379059563 0.158530404483429 1.68242040397124 0.35 9.2 9 2 brain inflammation 0.0434567379059563 0.158530404483429 1.68242040397124 0.35 9.2 9 2 increased mammary adenocarcinoma incidence 0.0434567379059563 0.158530404483429 1.68242040397124 0.35 9.2 9 2 decreased myocardial infarction size 0.0434567379059563 0.158530404483429 1.68242040397124 0.35 9.2 9 2 abnormal lens epithelium morphology 0.0434567379059563 0.158530404483429 1.68242040397124 0.35 9.2 9 2 abnormal sperm mitochondrial sheath morphology 0.0434567379059563 0.158530404483429 1.68242040397124 0.35 9.2 9 2 abnormal circulating cytokine level 0.0434567379059563 0.158530404483429 1.68242040397124 0.35 9.2 9 2 short tail 7.70633734391793e-05 0.00132950676058785 1.67952467177852 0.349397590361446 9.2 9 2 increased circulating creatinine level 6.0490012676989e-05 0.00111534315527595 1.6768309674132 0.348837209302326 9.2 9 2 increased bone mineral content 6.89335659525329e-06 0.00018111326577104 1.67580538272365 0.348623853211009 9.2 9 2 abnormal skin morphology 0.000427006085434444 0.00521954613031047 1.67513719875925 0.348484848484849 9.2 9 2 anophthalmia 4.7494172664567e-05 0.000908782726947003 1.67431886109498 0.348314606741573 9.2 9 2 abnormal rib morphology 6.29634358164853e-07 2.30325803813981e-05 1.67351870871214 0.348148148148148 9.2 9 2 embryonic lethality, complete penetrance 2.44965092056651e-14 3.93129462252205e-12 1.67262574868614 0.347962382445141 9.2 9 2 abnormal testis morphology 4.27071879960404e-06 0.000120294406438872 1.67197058779751 0.347826086956522 9.2 9 2 abnormal immune system morphology 0.0031338830765243 0.0253513305783877 1.67197058779751 0.347826086956522 9.2 9 2 abnormal sleep pattern 0.0031338830765243 0.0253513305783877 1.67197058779751 0.347826086956522 9.2 9 2 abnormal myelin sheath morphology 0.0031338830765243 0.0253513305783877 1.67197058779751 0.347826086956522 9.2 9 2 blistering 0.0328833718419627 0.134327195904446 1.67197058779751 0.347826086956522 9.2 9 2 conjunctivitis 0.0328833718419627 0.134327195904446 1.67197058779751 0.347826086956522 9.2 9 2 pancreas inflammation 0.0328833718419627 0.134327195904446 1.67197058779751 0.347826086956522 9.2 9 2 abnormal cochlear ganglion morphology 0.0328833718419627 0.134327195904446 1.67197058779751 0.347826086956522 9.2 9 2 abnormal ulna morphology 0.0328833718419627 0.134327195904446 1.67197058779751 0.347826086956522 9.2 9 2 abnormal chondrocyte physiology 0.0328833718419627 0.134327195904446 1.67197058779751 0.347826086956522 9.2 9 2 abnormal brain morphology 5.82259459671064e-08 2.86806020976588e-06 1.67197058779751 0.347826086956522 9.2 9 2 increased lymphocyte cell number 0.00033400938416789 0.00422823584283779 1.67197058779751 0.347826086956522 9.2 9 2 abnormal forebrain development 0.000261398466584283 0.00345866322142768 1.66906786108258 0.347222222222222 9.2 9 2 decreased grip strength 3.16685120752108e-10 2.67035334871481e-08 1.66815330335048 0.34703196347032 9.2 9 2 abnormal pulmonary alveolus morphology 1.80947256452915e-05 0.00039832415966958 1.66576277620915 0.346534653465347 9.2 9 2 abnormal glucose homeostasis 1.10897021234621e-08 6.56800810288378e-07 1.66393226766387 0.346153846153846 9.2 9 2 increased circulating alanine transaminase level 0.000160321606678872 0.00236676555853824 1.66393226766387 0.346153846153846 9.2 9 2 increased percent body fat/body weight 0.00189280599444702 0.0173101283499521 1.66393226766387 0.346153846153846 9.2 9 2 abnormal stomach morphology 0.0250085954625922 0.115415364031907 1.66393226766387 0.346153846153846 9.2 9 2 no spontaneous movement 0.0250085954625922 0.115415364031907 1.66393226766387 0.346153846153846 9.2 9 2 decreased bone resorption 0.0250085954625922 0.115415364031907 1.66393226766387 0.346153846153846 9.2 9 2 decreased body size 3.88464571599719e-33 3.86522248741721e-30 1.66254218222722 0.345864661654135 9.2 9 2 increased sensitivity to xenobiotic induced morbidity/mortality 8.79473427335877e-06 0.000219868356833969 1.66057078833525 0.345454545454545 9.2 9 2 abnormal platelet physiology 0.00147331182715502 0.014232478330284 1.66057078833525 0.345454545454545 9.2 9 2 abnormal embryo size 6.91739112270495e-06 0.00018111326577104 1.659023912892 0.345132743362832 9.2 9 2 embryonic growth arrest 1.98164436109623e-10 1.76047869579531e-08 1.65828087228607 0.344978165938865 9.2 9 2 abnormal embryonic neuroepithelium morphology 0.00114783317306782 0.0115596559433449 1.65755704824753 0.344827586206897 9.2 9 2 abnormal microglial cell morphology 0.0190974323750789 0.0927829356113451 1.65755704824753 0.344827586206897 9.2 9 2 increased susceptibility to induced arthritis 0.0190974323750789 0.0927829356113451 1.65755704824753 0.344827586206897 9.2 9 2 short limbs 7.72391015364109e-05 0.00132950676058785 1.65755704824753 0.344827586206897 9.2 9 2 increased circulating follicle stimulating hormone level 0.0146327079899712 0.0775268607562371 1.65237718247176 0.34375 9.2 9 2 decreased white adipose tissue amount 0.000545348018818034 0.00632425732778489 1.65013515101657 0.343283582089552 9.2 9 2 increased circulating serum albumin level 0.0112435873055504 0.0613342618915714 1.64808529368612 0.342857142857143 9.2 9 2 abnormal intestinal goblet cell morphology 0.0112435873055504 0.0613342618915714 1.64808529368612 0.342857142857143 9.2 9 2 abnormal embryonic epiblast morphology 0.0112435873055504 0.0613342618915714 1.64808529368612 0.342857142857143 9.2 9 2 decreased glycogen level 0.0112435873055504 0.0613342618915714 1.64808529368612 0.342857142857143 9.2 9 2 abnormal hippocampus pyramidal cell morphology 0.0112435873055504 0.0613342618915714 1.64808529368612 0.342857142857143 9.2 9 2 increased sensitivity to induced morbidity/mortality 1.78427889470045e-08 1.00872585240168e-06 1.64584604736317 0.342391304347826 9.2 9 2 abnormal behavior 5.69528215146394e-12 6.74619731036502e-10 1.64265095968415 0.341726618705036 9.2 9 2 increased tumor growth/size 0.00668449859520182 0.0418306673095963 1.64138575997194 0.341463414634146 9.2 9 2 short humerus 0.00668449859520182 0.0418306673095963 1.64138575997194 0.341463414634146 9.2 9 2 lethality at weaning, incomplete penetrance 0.00668449859520182 0.0418306673095963 1.64138575997194 0.341463414634146 9.2 9 2 abnormal myelopoiesis 0.00516883516154433 0.0351613504044123 1.63872117269926 0.340909090909091 9.2 9 2 decreased macrophage cell number 0.00516883516154433 0.0351613504044123 1.63872117269926 0.340909090909091 9.2 9 2 abnormal T-helper 1 physiology 0.00400323037585238 0.0304062154501765 1.63639674550394 0.340425531914894 9.2 9 2 premature death 1.06729437694438e-33 1.32744738132457e-30 1.63580281521013 0.340301974448316 9.2 9 2 abnormal hindlimb morphology 0.00310487055873972 0.0252397565845263 1.63435124957206 0.34 9.2 9 2 decreased circulating alkaline phosphatase level 0.00310487055873972 0.0252397565845263 1.63435124957206 0.34 9.2 9 2 abnormal colon morphology 0.00145886982141606 0.0141479090868322 1.6294628609891 0.338983050847458 9.2 9 2 female infertility 3.72182275944341e-11 3.7032136456462e-09 1.62639996087446 0.338345864661654 9.2 9 2 abnormal embryo development 2.06366188186809e-06 6.79915090218129e-05 1.62586845761927 0.338235294117647 9.2 9 2 increased circulating free fatty acid level 0.000539722062710517 0.00627363846258136 1.62487282476096 0.338028169014085 9.2 9 2 decreased liver weight 0.000539722062710517 0.00627363846258136 1.62487282476096 0.338028169014085 9.2 9 2 cardiac hypertrophy 5.96170881736879e-05 0.00111501884836127 1.61865519915601 0.336734693877551 9.2 9 2 infertility 2.88078711911682e-05 0.00058737360318058 1.61727996109385 0.336448598130841 9.2 9 2 enlarged heart 1.00940618948521e-09 7.38499381277783e-08 1.61611812204134 0.336206896551724 9.2 9 2 reduced female fertility 1.00940618948521e-09 7.38499381277783e-08 1.61611812204134 0.336206896551724 9.2 9 2 embryonic lethality before implantation, complete penetrance 6.77480379140444e-06 0.000179280047139559 1.61512358781239 0.336 9.2 9 2 decreased litter size 2.83395973550179e-11 2.93728118419196e-09 1.60800730018604 0.334519572953737 9.2 9 2 insulin resistance 5.24333925490678e-06 0.000142544332203067 1.60230514663928 0.333333333333333 9.2 9 2 abnormal neuron morphology 7.47717072942141e-05 0.00132380513803813 1.60230514663928 0.333333333333333 9.2 9 2 muscular ventricular septal defect 0.0018387765415166 0.0168780688082012 1.60230514663928 0.333333333333333 9.2 9 2 increased macrophage cell number 0.00236420202602758 0.020419974096332 1.60230514663928 0.333333333333333 9.2 9 2 diluted coat color 0.0030430619442044 0.0248591677707995 1.60230514663928 0.333333333333333 9.2 9 2 abnormal gastrulation 0.00392156931122699 0.0298315096687374 1.60230514663928 0.333333333333333 9.2 9 2 abnormal cardiovascular system morphology 0.0050604971713481 0.0351613504044123 1.60230514663928 0.333333333333333 9.2 9 2 thymus atrophy 0.0050604971713481 0.0351613504044123 1.60230514663928 0.333333333333333 9.2 9 2 abnormal systemic arterial blood pressure 0.0142776012643329 0.076131903847863 1.60230514663928 0.333333333333333 9.2 9 2 abnormal epidermis stratum granulosum morphology 0.0142776012643329 0.076131903847863 1.60230514663928 0.333333333333333 9.2 9 2 reduced long term depression 0.0142776012643329 0.076131903847863 1.60230514663928 0.333333333333333 9.2 9 2 abnormal limb bone morphology 0.0142776012643329 0.076131903847863 1.60230514663928 0.333333333333333 9.2 9 2 abnormal trophoblast giant cell morphology 0.0142776012643329 0.076131903847863 1.60230514663928 0.333333333333333 9.2 9 2 dextrocardia 0.0186101169258568 0.0910376909598206 1.60230514663928 0.333333333333333 9.2 9 2 abnormal middle ear ossicle morphology 0.0186101169258568 0.0910376909598206 1.60230514663928 0.333333333333333 9.2 9 2 cardiovascular system phenotype 0.0186101169258568 0.0910376909598206 1.60230514663928 0.333333333333333 9.2 9 2 abnormal heart tube morphology 0.0243322318345623 0.112909265623331 1.60230514663928 0.333333333333333 9.2 9 2 thin epidermis 0.0319313043604733 0.131505164895161 1.60230514663928 0.333333333333333 9.2 9 2 abnormal eye muscle morphology 0.0319313043604733 0.131505164895161 1.60230514663928 0.333333333333333 9.2 9 2 abnormal malleus morphology 0.042092352338758 0.155579088324904 1.60230514663928 0.333333333333333 9.2 9 2 ocular hypertelorism 0.042092352338758 0.155579088324904 1.60230514663928 0.333333333333333 9.2 9 2 abnormal nursing 0.042092352338758 0.155579088324904 1.60230514663928 0.333333333333333 9.2 9 2 hemolytic anemia 0.042092352338758 0.155579088324904 1.60230514663928 0.333333333333333 9.2 9 2 abnormal osteoblast morphology 0.042092352338758 0.155579088324904 1.60230514663928 0.333333333333333 9.2 9 2 abnormal stomach glandular epithelium morphology 0.0745015557397233 0.234164173588701 1.60230514663928 0.333333333333333 9.2 9 2 abnormal radius morphology 0.0745015557397233 0.234164173588701 1.60230514663928 0.333333333333333 9.2 9 2 abnormal phrenic nerve morphology 0.0745015557397233 0.234164173588701 1.60230514663928 0.333333333333333 9.2 9 2 eye inflammation 0.0745015557397233 0.234164173588701 1.60230514663928 0.333333333333333 9.2 9 2 abnormal thyroid cartilage morphology 0.0745015557397233 0.234164173588701 1.60230514663928 0.333333333333333 9.2 9 2 abnormal white adipose tissue morphology 0.0745015557397233 0.234164173588701 1.60230514663928 0.333333333333333 9.2 9 2 increased circulating renin level 0.0745015557397233 0.234164173588701 1.60230514663928 0.333333333333333 9.2 9 2 darkened coat color 0.0745015557397233 0.234164173588701 1.60230514663928 0.333333333333333 9.2 9 2 abnormal glycogen homeostasis 0.0745015557397233 0.234164173588701 1.60230514663928 0.333333333333333 9.2 9 2 small thoracic cage 0.0745015557397233 0.234164173588701 1.60230514663928 0.333333333333333 9.2 9 2 primary atelectasis 0.0745015557397233 0.234164173588701 1.60230514663928 0.333333333333333 9.2 9 2 increased effector memory CD8-positive, alpha-beta T cell number 0.0745015557397233 0.234164173588701 1.60230514663928 0.333333333333333 9.2 9 2 abnormal metanephric mesenchyme morphology 0.0745015557397233 0.234164173588701 1.60230514663928 0.333333333333333 9.2 9 2 abnormal hypoglossal nerve topology 0.0745015557397233 0.234164173588701 1.60230514663928 0.333333333333333 9.2 9 2 increased adipocyte glucose uptake 0.0745015557397233 0.234164173588701 1.60230514663928 0.333333333333333 9.2 9 2 interdigital webbing 0.100432313049093 0.289988831932233 1.60230514663928 0.333333333333333 9.2 9 2 decreased salivation 0.100432313049093 0.289988831932233 1.60230514663928 0.333333333333333 9.2 9 2 abnormal enteric neuron morphology 0.100432313049093 0.289988831932233 1.60230514663928 0.333333333333333 9.2 9 2 abnormal pup retrieval 0.100432313049093 0.289988831932233 1.60230514663928 0.333333333333333 9.2 9 2 abnormal seizure response to electrical stimulation 0.100432313049093 0.289988831932233 1.60230514663928 0.333333333333333 9.2 9 2 placental labyrinth hypoplasia 0.100432313049093 0.289988831932233 1.60230514663928 0.333333333333333 9.2 9 2 abnormal respiratory system morphology 0.100432313049093 0.289988831932233 1.60230514663928 0.333333333333333 9.2 9 2 altered righting response 0.100432313049093 0.289988831932233 1.60230514663928 0.333333333333333 9.2 9 2 increased alcohol consumption 0.100432313049093 0.289988831932233 1.60230514663928 0.333333333333333 9.2 9 2 abnormal glial cell morphology 0.100432313049093 0.289988831932233 1.60230514663928 0.333333333333333 9.2 9 2 abnormal placenta size 0.100432313049093 0.289988831932233 1.60230514663928 0.333333333333333 9.2 9 2 abnormal cerebral aqueduct morphology 0.100432313049093 0.289988831932233 1.60230514663928 0.333333333333333 9.2 9 2 decreased trabecular bone mass 0.100432313049093 0.289988831932233 1.60230514663928 0.333333333333333 9.2 9 2 herniated liver 0.100432313049093 0.289988831932233 1.60230514663928 0.333333333333333 9.2 9 2 decreased brown adipose tissue mass 0.100432313049093 0.289988831932233 1.60230514663928 0.333333333333333 9.2 9 2 increased neuron apoptosis 0.000323947342905931 0.00418664566957444 1.60230514663928 0.333333333333333 9.2 9 2 increased incidence of induced tumors 0.0557985422927164 0.194668827423748 1.60230514663928 0.333333333333333 9.2 9 2 decreased cochlear outer hair cell number 0.0557985422927164 0.194668827423748 1.60230514663928 0.333333333333333 9.2 9 2 increased acute inflammation 0.0557985422927164 0.194668827423748 1.60230514663928 0.333333333333333 9.2 9 2 postnatal growth retardation 3.58404846923478e-22 1.98118234827145e-19 1.59445070964595 0.331699346405229 9.2 9 2 decreased T cell proliferation 1.96979822344224e-06 6.62145010920617e-05 1.59147876051334 0.331081081081081 9.2 9 2 thrombocytopenia 2.50323614790829e-06 7.98307681784854e-05 1.59125476631763 0.331034482758621 9.2 9 2 increased blood urea nitrogen level 2.50323614790829e-06 7.98307681784854e-05 1.59125476631763 0.331034482758621 9.2 9 2 lung inflammation 5.14214391839265e-06 0.000141337933668527 1.59052349114928 0.330882352941176 9.2 9 2 abnormal vertebrae morphology 4.50517771860487e-05 0.000868730974808498 1.5876050994224 0.330275229357798 9.2 9 2 increased monocyte cell number 9.33187102478654e-05 0.00155271098154893 1.58628209517289 0.33 9.2 9 2 enlarged spleen 5.36919074418601e-11 5.13686999083181e-09 1.58561446802845 0.329861111111111 9.2 9 2 abnormal developmental patterning 0.000404573177685015 0.00505716472106268 1.58276483997295 0.329268292682927 9.2 9 2 embryonic lethality between somite formation and embryo turning, complete penetrance 0.0010870551768942 0.011082171116903 1.57941507311586 0.328571428571429 9.2 9 2 decreased circulating HDL cholesterol level 1.31450793258127e-05 0.000307027087539522 1.57726912872304 0.328125 9.2 9 2 decreased circulating LDL cholesterol level 0.00178956790309473 0.0164567473528582 1.57726912872304 0.328125 9.2 9 2 decreased circulating calcium level 0.00380672416330949 0.0291809749036436 1.57317232579129 0.327272727272727 9.2 9 2 abnormal contextual conditioning behavior 0.00380672416330949 0.0291809749036436 1.57317232579129 0.327272727272727 9.2 9 2 abnormal snout morphology 0.00490696863652013 0.0351613504044123 1.57149158612698 0.326923076923077 9.2 9 2 increased susceptibility to injury 0.00490696863652013 0.0351613504044123 1.57149158612698 0.326923076923077 9.2 9 2 increased circulating LDL cholesterol level 0.00633386136004293 0.0408173060443181 1.56960504160582 0.326530612244898 9.2 9 2 abnormal craniofacial development 0.00633386136004293 0.0408173060443181 1.56960504160582 0.326530612244898 9.2 9 2 failure to gastrulate 0.0081882417184734 0.049800125366021 1.56747242606016 0.326086956521739 9.2 9 2 abnormal left-right axis patterning 0.010603939075026 0.0584744338744724 1.56504223625232 0.325581395348837 9.2 9 2 abnormal retinal pigment epithelium morphology 0.000642511089899264 0.00726475607329281 1.5622475179733 0.325 9.2 9 2 impaired ovarian folliculogenesis 0.0137595446017806 0.0738443736719077 1.5622475179733 0.325 9.2 9 2 increased B cell number 4.26795049231009e-05 0.000829416160126668 1.56122039928955 0.324786324786325 9.2 9 2 decreased body weight 1.42471042102254e-40 2.36264478152904e-37 1.56088853541759 0.324717285945073 9.2 9 2 small seminiferous tubules 0.00105296548954343 0.0108682641296236 1.55899960213551 0.324324324324324 9.2 9 2 increased brown adipose tissue amount 0.0178949538275986 0.0879717344785601 1.55899960213551 0.324324324324324 9.2 9 2 abnormal branching of the mammary ductal tree 0.0178949538275986 0.0879717344785601 1.55899960213551 0.324324324324324 9.2 9 2 abnormal hair follicle development 0.0178949538275986 0.0879717344785601 1.55899960213551 0.324324324324324 9.2 9 2 abnormal calcium ion homeostasis 0.0178949538275986 0.0879717344785601 1.55899960213551 0.324324324324324 9.2 9 2 decreased susceptibility to injury 0.00173036718065808 0.0159713853873357 1.5551785246793 0.323529411764706 9.2 9 2 impaired synaptic plasticity 0.0233349844056818 0.109417104069997 1.5551785246793 0.323529411764706 9.2 9 2 abnormal eyelid morphology 0.0305237593039004 0.127824665435105 1.55061788384446 0.32258064516129 9.2 9 2 abnormal object recognition memory 0.0305237593039004 0.127824665435105 1.55061788384446 0.32258064516129 9.2 9 2 abnormal nose morphology 0.0305237593039004 0.127824665435105 1.55061788384446 0.32258064516129 9.2 9 2 inner cell mass degeneration 0.0305237593039004 0.127824665435105 1.55061788384446 0.32258064516129 9.2 9 2 decreased insulin secretion 0.000379935476762001 0.00478526328326824 1.54889497508464 0.322222222222222 9.2 9 2 increased hemoglobin content 0.00366830500537695 0.0290140181267891 1.54798971793964 0.322033898305085 9.2 9 2 reduced long term potentiation 8.52608736468076e-05 0.00143301637294888 1.54507996283073 0.321428571428571 9.2 9 2 abnormal eye development 0.00472196095134739 0.0346591936999523 1.54507996283073 0.321428571428571 9.2 9 2 abnormal ovulation 0.0400759940283583 0.150815484335161 1.54507996283073 0.321428571428571 9.2 9 2 abnormal respiration 0.0400759940283583 0.150815484335161 1.54507996283073 0.321428571428571 9.2 9 2 abnormal spleen germinal center morphology 0.0400759940283583 0.150815484335161 1.54507996283073 0.321428571428571 9.2 9 2 premature aging 0.0400759940283583 0.150815484335161 1.54507996283073 0.321428571428571 9.2 9 2 decreased circulating progesterone level 0.0400759940283583 0.150815484335161 1.54507996283073 0.321428571428571 9.2 9 2 abnormal brainstem morphology 0.0400759940283583 0.150815484335161 1.54507996283073 0.321428571428571 9.2 9 2 increased body length 0.00785338644300912 0.0482353056221856 1.53821294077371 0.32 9.2 9 2 abnormal circulating protein level 0.00785338644300912 0.0482353056221856 1.53821294077371 0.32 9.2 9 2 abnormal egg cylinder morphology 0.0528558816098902 0.187238608972362 1.53821294077371 0.32 9.2 9 2 abnormal cochlear outer hair cell morphology 0.0528558816098902 0.187238608972362 1.53821294077371 0.32 9.2 9 2 decreased placenta weight 0.0528558816098902 0.187238608972362 1.53821294077371 0.32 9.2 9 2 abnormal energy expenditure 0.0528558816098902 0.187238608972362 1.53821294077371 0.32 9.2 9 2 abnormal tibia morphology 0.010149965785327 0.0571222621968348 1.53412194890995 0.319148936170213 9.2 9 2 abnormal cell nucleus morphology 0.010149965785327 0.0571222621968348 1.53412194890995 0.319148936170213 9.2 9 2 short femur 0.000596234200156622 0.00688228572106541 1.52947309451931 0.318181818181818 9.2 9 2 lethality, incomplete penetrance 0.0131403209013174 0.0709805607861607 1.52947309451931 0.318181818181818 9.2 9 2 abnormal female reproductive system physiology 0.0701032844022234 0.229752200198328 1.52947309451931 0.318181818181818 9.2 9 2 abnormal retinal layer morphology 0.0701032844022234 0.229752200198328 1.52947309451931 0.318181818181818 9.2 9 2 abnormal limb posture 0.0701032844022234 0.229752200198328 1.52947309451931 0.318181818181818 9.2 9 2 abnormal occipital bone morphology 0.0701032844022234 0.229752200198328 1.52947309451931 0.318181818181818 9.2 9 2 abnormal sperm midpiece morphology 0.0701032844022234 0.229752200198328 1.52947309451931 0.318181818181818 9.2 9 2 increased bone volume 0.0701032844022234 0.229752200198328 1.52947309451931 0.318181818181818 9.2 9 2 increased circulating aspartate transaminase level 0.00351391878245432 0.028150959650097 1.52600490156122 0.317460317460317 9.2 9 2 cachexia 0.000216068051415118 0.0030194903252534 1.52527124535854 0.317307692307692 9.2 9 2 decreased food intake 0.00124487970298226 0.0124864446014854 1.5211757721259 0.316455696202532 9.2 9 2 decreased brain weight 0.00581015737841808 0.0378344672220287 1.51797329681616 0.315789473684211 9.2 9 2 increased bone marrow cell number 0.0221570900360597 0.104447042279846 1.51797329681616 0.315789473684211 9.2 9 2 short vibrissae 0.0936461784731425 0.274214089407819 1.51797329681616 0.315789473684211 9.2 9 2 altered susceptibility to infection 0.0936461784731425 0.274214089407819 1.51797329681616 0.315789473684211 9.2 9 2 abnormal neural crest cell migration 0.0936461784731425 0.274214089407819 1.51797329681616 0.315789473684211 9.2 9 2 maternal imprinting 0.0936461784731425 0.274214089407819 1.51797329681616 0.315789473684211 9.2 9 2 decreased eye pigmentation 0.0936461784731425 0.274214089407819 1.51797329681616 0.315789473684211 9.2 9 2 decreased liver regeneration 0.0936461784731425 0.274214089407819 1.51797329681616 0.315789473684211 9.2 9 2 embryonic lethality between implantation and somite formation, incomplete penetrance 0.0936461784731425 0.274214089407819 1.51797329681616 0.315789473684211 9.2 9 2 abnormal locomotor behavior 0.000571025750620576 0.00660663513799388 1.51522334519149 0.315217391304348 9.2 9 2 axon degeneration 0.00748344638387645 0.04647958272133 1.51328819404821 0.314814814814815 9.2 9 2 decreased platelet aggregation 0.00748344638387645 0.04647958272133 1.51328819404821 0.314814814814815 9.2 9 2 domed cranium 0.00261260124896685 0.0223712413315148 1.51074485254561 0.314285714285714 9.2 9 2 abnormal midbrain development 0.0288768747432421 0.124802435469392 1.51074485254561 0.314285714285714 9.2 9 2 holoprosencephaly 0.0288768747432421 0.124802435469392 1.51074485254561 0.314285714285714 9.2 9 2 increased lung adenocarcinoma incidence 0.00965078856039523 0.0554044657526653 1.50805190271932 0.313725490196078 9.2 9 2 abnormal cervical vertebrae morphology 0.00965078856039523 0.0554044657526653 1.50805190271932 0.313725490196078 9.2 9 2 abnormal gluconeogenesis 0.00965078856039523 0.0554044657526653 1.50805190271932 0.313725490196078 9.2 9 2 abnormal response to novel object 0.00965078856039523 0.0554044657526653 1.50805190271932 0.313725490196078 9.2 9 2 increased kidney weight 0.00965078856039523 0.0554044657526653 1.50805190271932 0.313725490196078 9.2 9 2 microphthalmia 1.30228089395219e-05 0.000305606011670385 1.50805190271932 0.313725490196078 9.2 9 2 hydroencephaly 0.000155482396655109 0.00230215750999752 1.50477352901776 0.31304347826087 9.2 9 2 reduced male fertility 1.4846052601499e-07 6.65397402634751e-06 1.50348456490822 0.312775330396476 9.2 9 2 abnormal intestinal epithelium morphology 0.0124633606098629 0.0673969772109432 1.50216107497432 0.3125 9.2 9 2 oligodactyly 0.0124633606098629 0.0673969772109432 1.50216107497432 0.3125 9.2 9 2 curly tail 0.0124633606098629 0.0673969772109432 1.50216107497432 0.3125 9.2 9 2 abnormal lymphatic vessel morphology 0.0377469644465956 0.14669511663031 1.50216107497432 0.3125 9.2 9 2 increased dopamine level 0.0377469644465956 0.14669511663031 1.50216107497432 0.3125 9.2 9 2 abnormal lumbar vertebrae morphology 0.0377469644465956 0.14669511663031 1.50216107497432 0.3125 9.2 9 2 abnormal auditory brainstem response waveform shape 0.0377469644465956 0.14669511663031 1.50216107497432 0.3125 9.2 9 2 absent mandible 0.126283358685492 0.342375863466117 1.50216107497432 0.3125 9.2 9 2 failure of tooth eruption 0.126283358685492 0.342375863466117 1.50216107497432 0.3125 9.2 9 2 white spotting 0.126283358685492 0.342375863466117 1.50216107497432 0.3125 9.2 9 2 paternal imprinting 0.126283358685492 0.342375863466117 1.50216107497432 0.3125 9.2 9 2 decreased cochlear coiling 0.126283358685492 0.342375863466117 1.50216107497432 0.3125 9.2 9 2 impaired muscle relaxation 0.126283358685492 0.342375863466117 1.50216107497432 0.3125 9.2 9 2 abnormal molar crown morphology 0.126283358685492 0.342375863466117 1.50216107497432 0.3125 9.2 9 2 small pancreas 0.126283358685492 0.342375863466117 1.50216107497432 0.3125 9.2 9 2 increased thymus weight 0.126283358685492 0.342375863466117 1.50216107497432 0.3125 9.2 9 2 abnormal wound healing 0.126283358685492 0.342375863466117 1.50216107497432 0.3125 9.2 9 2 decreased circulating prolactin level 0.126283358685492 0.342375863466117 1.50216107497432 0.3125 9.2 9 2 abnormal pancreatic alpha cell morphology 0.126283358685492 0.342375863466117 1.50216107497432 0.3125 9.2 9 2 dystonia 0.126283358685492 0.342375863466117 1.50216107497432 0.3125 9.2 9 2 abnormal neuron differentiation 0.00019776936297954 0.00281115023092346 1.50216107497432 0.3125 9.2 9 2 abnormal NK cell physiology 0.0055190548645382 0.0360805492129797 1.49723595669572 0.311475409836066 9.2 9 2 abnormal motor capabilities/coordination/movement 6.89726109732221e-05 0.00124325630286877 1.49305706845933 0.310606060606061 9.2 9 2 thrombocytosis 0.0070941718076911 0.0441720960491404 1.49180134342278 0.310344827586207 9.2 9 2 abnormal middle ear morphology 0.0495163467723341 0.178510018255335 1.49180134342278 0.310344827586207 9.2 9 2 aphagia 0.0495163467723341 0.178510018255335 1.49180134342278 0.310344827586207 9.2 9 2 increased double-positive T cell number 0.0495163467723341 0.178510018255335 1.49180134342278 0.310344827586207 9.2 9 2 increased food intake 0.00144309213362016 0.0140222331342975 1.48785477902219 0.30952380952381 9.2 9 2 abnormal optic nerve morphology 0.0208895382631167 0.0996408943998138 1.48785477902219 0.30952380952381 9.2 9 2 abnormal learning/memory/conditioning 0.00912829579834059 0.0545832591307025 1.48577386324733 0.309090909090909 9.2 9 2 abnormal joint morphology 0.00912829579834059 0.0545832591307025 1.48577386324733 0.309090909090909 9.2 9 2 preweaning lethality, complete penetrance 3.77687156653314e-20 1.5658280036252e-17 1.48104962202874 0.308108108108108 9.2 9 2 abnormal lipid homeostasis 0.000105653308391204 0.0016955651911169 1.4790509045901 0.307692307692308 9.2 9 2 decreased cardiac muscle contractility 0.000492646357480357 0.00589162410688648 1.4790509045901 0.307692307692308 9.2 9 2 increased embryonic tissue cell apoptosis 0.00235378907360605 0.0203653924194611 1.4790509045901 0.307692307692308 9.2 9 2 absent corpus luteum 0.0117591529710065 0.0640063304494061 1.4790509045901 0.307692307692308 9.2 9 2 abnormal circulating hormone level 0.0271236147798677 0.123911830605915 1.4790509045901 0.307692307692308 9.2 9 2 abnormal leukocyte cell number 0.0652324532309117 0.221826011499512 1.4790509045901 0.307692307692308 9.2 9 2 thick skin 0.0652324532309117 0.221826011499512 1.4790509045901 0.307692307692308 9.2 9 2 pulmonary edema 0.0652324532309117 0.221826011499512 1.4790509045901 0.307692307692308 9.2 9 2 decreased neutrophil cell number 0.00022761671863936 0.00313682320008536 1.4790509045901 0.307692307692308 9.2 9 2 postnatal lethality 1.36344096816182e-05 0.00031403327854653 1.47682341828801 0.307228915662651 9.2 9 2 abnormal T cell differentiation 0.0006267192920974 0.00711855816937116 1.47538988749953 0.306930693069307 9.2 9 2 abnormal suckling behavior 0.00136724529988524 0.013363546889841 1.47484905542934 0.306818181818182 9.2 9 2 increased T cell number 0.00136724529988524 0.013363546889841 1.47484905542934 0.306818181818182 9.2 9 2 abnormal respiratory system physiology 0.0151675514553716 0.0795976460869976 1.47150472650546 0.306122448979592 9.2 9 2 decreased circulating cholesterol level 6.07395607475408e-06 0.000162461997160761 1.47096865920983 0.306010928961749 9.2 9 2 abnormal digit morphology 0.00384673075532176 0.0294422853965012 1.46877971775267 0.305555555555556 9.2 9 2 abnormal lysosome morphology 0.0353005550739622 0.139270627670866 1.46877971775267 0.305555555555556 9.2 9 2 sparse hair 0.00222379048416123 0.0199699596727475 1.46552299997495 0.304878048780488 9.2 9 2 abnormal allantois morphology 0.0195916885161512 0.0945462099854551 1.46297426432282 0.304347826086957 9.2 9 2 embryonic lethality between implantation and placentation, complete penetrance 0.0195916885161512 0.0945462099854551 1.46297426432282 0.304347826086957 9.2 9 2 abnormal carpal bone morphology 0.0863869961473373 0.254908247825031 1.46297426432282 0.304347826086957 9.2 9 2 abnormal circulating insulin level 0.0863869961473373 0.254908247825031 1.46297426432282 0.304347826086957 9.2 9 2 failure of embryo implantation 0.0863869961473373 0.254908247825031 1.46297426432282 0.304347826086957 9.2 9 2 abnormal cardiovascular development 0.0863869961473373 0.254908247825031 1.46297426432282 0.304347826086957 9.2 9 2 decreased T cell number 2.61978810782712e-05 0.000543060243184997 1.46297426432282 0.304347826086957 9.2 9 2 decreased spleen weight 0.00492167305513333 0.0351613504044123 1.46297426432282 0.304347826086957 9.2 9 2 impaired balance 0.000753776054859668 0.00837061578778314 1.46092528075934 0.303921568627451 9.2 9 2 hunched posture 0.00283767679896916 0.0238873808373461 1.46032874124086 0.30379746835443 9.2 9 2 postnatal lethality, complete penetrance 1.52936544048363e-10 1.38338055752838e-08 1.45701841054504 0.303108808290155 9.2 9 2 abnormal tail morphology 0.00630082479459025 0.0407098744845279 1.45664104239934 0.303030303030303 9.2 9 2 increased cardiomyocyte apoptosis 0.0460673329338733 0.166801296467263 1.45664104239934 0.303030303030303 9.2 9 2 abnormal QRS complex 0.0460673329338733 0.166801296467263 1.45664104239934 0.303030303030303 9.2 9 2 decreased sensitivity to xenobiotic induced morbidity/mortality 0.0460673329338733 0.166801296467263 1.45664104239934 0.303030303030303 9.2 9 2 no abnormal phenotype detected 4.96270124085412e-43 1.23447193366246e-39 1.45454213599819 0.302593659942363 9.2 9 2 increased oxygen consumption 0.00209566828891348 0.0188875901038851 1.45325350509144 0.302325581395349 9.2 9 2 abnormal male reproductive system morphology 0.0253466312446228 0.116113711272558 1.45325350509144 0.302325581395349 9.2 9 2 decreased oxygen consumption 0.0253466312446228 0.116113711272558 1.45325350509144 0.302325581395349 9.2 9 2 abnormal placenta development 0.0142126039514224 0.076131903847863 1.45114428374878 0.30188679245283 9.2 9 2 abnormal seminiferous tubule morphology 8.4787537635645e-05 0.00142989152453334 1.44865944764647 0.301369863013699 9.2 9 2 astrocytosis 0.00462641694318405 0.0342506313874117 1.44865944764647 0.301369863013699 9.2 9 2 decreased percent body fat/body weight 0.00462641694318405 0.0342506313874117 1.44865944764647 0.301369863013699 9.2 9 2 hypoglycemia 0.00154930856227142 0.01474471177284 1.44724335825483 0.301075268817204 9.2 9 2 decreased anxiety-related response 0.000309633215322523 0.0040537506479725 1.44598269330862 0.300813008130081 9.2 9 2 small testis 9.64386807453532e-08 4.61329266065512e-06 1.44555790403326 0.300724637681159 9.2 9 2 increased insulin sensitivity 0.00010722727191073 0.00171529156834688 1.44543611130396 0.300699300699301 9.2 9 2 abnormal retina morphology 3.45265958484426e-06 0.000102243937110715 1.44207463197535 0.3 9.2 9 2 oxidative stress 0.00197060802449476 0.0177926949580062 1.44207463197535 0.3 9.2 9 2 epidermal hyperplasia 0.0103476718727126 0.0575191816388212 1.44207463197535 0.3 9.2 9 2 increased erythrocyte cell number 0.0103476718727126 0.0575191816388212 1.44207463197535 0.3 9.2 9 2 decreased respiratory quotient 0.0183021936035269 0.0898849093559195 1.44207463197535 0.3 9.2 9 2 abnormal hair cycle 0.0603095388885221 0.20654598828643 1.44207463197535 0.3 9.2 9 2 gastrointestinal hemorrhage 0.0603095388885221 0.20654598828643 1.44207463197535 0.3 9.2 9 2 enhanced paired-pulse facilitation 0.0603095388885221 0.20654598828643 1.44207463197535 0.3 9.2 9 2 increased circulating insulin level 4.72282578795729e-05 0.000907183717957047 1.44207463197535 0.3 9.2 9 2 impaired fertilization 0.00591127525777611 0.038442607068544 1.44207463197535 0.3 9.2 9 2 abnormal skin pigmentation 0.0328510734276193 0.134327195904446 1.44207463197535 0.3 9.2 9 2 abnormal hearing physiology 0.115155938716223 0.31582182751555 1.44207463197535 0.3 9.2 9 2 abnormal fibula morphology 0.115155938716223 0.31582182751555 1.44207463197535 0.3 9.2 9 2 abnormal Peyer's patch T cell area morphology 0.115155938716223 0.31582182751555 1.44207463197535 0.3 9.2 9 2 decreased paired-pulse facilitation 0.115155938716223 0.31582182751555 1.44207463197535 0.3 9.2 9 2 absent placental labyrinth 0.115155938716223 0.31582182751555 1.44207463197535 0.3 9.2 9 2 abnormal male reproductive system physiology 0.115155938716223 0.31582182751555 1.44207463197535 0.3 9.2 9 2 abnormal optic stalk morphology 0.115155938716223 0.31582182751555 1.44207463197535 0.3 9.2 9 2 abnormal incus morphology 0.115155938716223 0.31582182751555 1.44207463197535 0.3 9.2 9 2 abnormal response to tactile stimuli 0.115155938716223 0.31582182751555 1.44207463197535 0.3 9.2 9 2 increased body weight 1.93490604764872e-06 6.54840652180433e-05 1.43778274318971 0.299107142857143 9.2 9 2 obese 0.00433838312535339 0.0322622661414546 1.43583188465078 0.298701298701299 9.2 9 2 seizures 0.00062947441789642 0.00713356544199246 1.43364144699304 0.298245614035088 9.2 9 2 decreased susceptibility to induced arthritis 0.0132755164644592 0.0716330741981393 1.43364144699304 0.298245614035088 9.2 9 2 neuron degeneration 0.0235972678565009 0.110438765367913 1.43184715231595 0.297872340425532 9.2 9 2 increased respiratory quotient 0.0235972678565009 0.110438765367913 1.43184715231595 0.297872340425532 9.2 9 2 abnormal T cell activation 0.00553278887051813 0.0361228669695901 1.42908296862422 0.297297297297297 9.2 9 2 abnormal long bone metaphysis morphology 0.0426644632935775 0.157576618326316 1.42908296862422 0.297297297297297 9.2 9 2 decreased caudal vertebrae number 0.00966519746282487 0.0554044657526653 1.42705302122561 0.296875 9.2 9 2 decreased eosinophil cell number 0.00966519746282487 0.0554044657526653 1.42705302122561 0.296875 9.2 9 2 increased sacral vertebrae number 0.00966519746282487 0.0554044657526653 1.42705302122561 0.296875 9.2 9 2 abnormal B cell differentiation 0.00234944341865471 0.0203632073306745 1.4262276579976 0.296703296703297 9.2 9 2 neurodegeneration 0.0170459334535471 0.0877685584245696 1.42427124145714 0.296296296296296 9.2 9 2 thick interventricular septum 0.0792539895974121 0.235396178057985 1.42427124145714 0.296296296296296 9.2 9 2 abnormal bone trabecula morphology 0.0792539895974121 0.235396178057985 1.42427124145714 0.296296296296296 9.2 9 2 increased circulating alkaline phosphatase level 6.66127302997823e-05 0.00120948296803437 1.42427124145714 0.296296296296296 9.2 9 2 improved glucose tolerance 1.29904493540137e-05 0.000305606011670385 1.42245456895528 0.295918367346939 9.2 9 2 abnormal nervous system physiology 0.000747796949434993 0.00832279602559081 1.42117499962788 0.295652173913043 9.2 9 2 azoospermia 8.39876871627042e-05 0.00142122021644372 1.42091211117068 0.29559748427673 9.2 9 2 abnormal astrocyte morphology 0.0304654065498799 0.127824665435105 1.42022501633936 0.295454545454545 9.2 9 2 muscular atrophy 0.0304654065498799 0.127824665435105 1.42022501633936 0.295454545454545 9.2 9 2 increased heart weight 0.000241555524372212 0.00329243488699111 1.41786714414843 0.294964028776978 9.2 9 2 absent gastric milk in neonates 0.00516830427426591 0.0351613504044123 1.41742378356552 0.294871794871795 9.2 9 2 hypoactivity 2.80690164699963e-09 1.88707239105718e-07 1.41529871042674 0.294429708222812 9.2 9 2 abnormal endoderm development 0.0555391448206196 0.194308892744432 1.41379865879936 0.294117647058824 9.2 9 2 abnormal spleen red pulp morphology 0.0555391448206196 0.194308892744432 1.41379865879936 0.294117647058824 9.2 9 2 abnormal interatrial septum morphology 0.154818009389726 0.362648150447024 1.41379865879936 0.294117647058824 9.2 9 2 abnormal urinary bladder morphology 0.154818009389726 0.362648150447024 1.41379865879936 0.294117647058824 9.2 9 2 abnormal ectoplacental cone morphology 0.154818009389726 0.362648150447024 1.41379865879936 0.294117647058824 9.2 9 2 decreased growth hormone level 0.154818009389726 0.362648150447024 1.41379865879936 0.294117647058824 9.2 9 2 coloboma 0.154818009389726 0.362648150447024 1.41379865879936 0.294117647058824 9.2 9 2 increased hepatoma incidence 0.154818009389726 0.362648150447024 1.41379865879936 0.294117647058824 9.2 9 2 decreased circulating glucose level 3.34061854286312e-07 1.35118514233691e-05 1.41278518305829 0.293906810035842 9.2 9 2 abnormal spermiogenesis 0.0158385130294606 0.0829437919174382 1.4089234910104 0.293103448275862 9.2 9 2 abnormal enzyme/coenzyme level 0.0158385130294606 0.0829437919174382 1.4089234910104 0.293103448275862 9.2 9 2 impaired coordination 2.29462202388393e-08 1.26841606320251e-06 1.40317473824191 0.291907514450867 9.2 9 2 abnormal heart left ventricle morphology 0.00838099236527103 0.0505399236572404 1.40201700330937 0.291666666666667 9.2 9 2 curly vibrissae 0.104625967127341 0.292160550468546 1.40201700330937 0.291666666666667 9.2 9 2 abnormal sensory capabilities/reflexes/nociception 0.104625967127341 0.292160550468546 1.40201700330937 0.291666666666667 9.2 9 2 abnormal primitive streak formation 0.104625967127341 0.292160550468546 1.40201700330937 0.291666666666667 9.2 9 2 increased body temperature 0.104625967127341 0.292160550468546 1.40201700330937 0.291666666666667 9.2 9 2 abnormal embryo turning 0.020294195055683 0.0968940694837071 1.39837540070337 0.290909090909091 9.2 9 2 decreased thymus weight 0.0724946305367764 0.234164173588701 1.39555609546002 0.290322580645161 9.2 9 2 decreased neuronal precursor cell number 0.0724946305367764 0.234164173588701 1.39555609546002 0.290322580645161 9.2 9 2 abnormal T cell proliferation 0.0724946305367764 0.234164173588701 1.39555609546002 0.290322580645161 9.2 9 2 small cranium 0.0724946305367764 0.234164173588701 1.39555609546002 0.290322580645161 9.2 9 2 abnormal mitochondrial ATP synthesis coupled electron transport 0.0724946305367764 0.234164173588701 1.39555609546002 0.290322580645161 9.2 9 2 abnormal liver physiology 0.00242443653643601 0.0208317301705857 1.39400547757617 0.29 9.2 9 2 decreased heart rate 0.00242443653643601 0.0208317301705857 1.39400547757617 0.29 9.2 9 2 abnormal dendritic cell physiology 0.00178640275794113 0.0164567473528582 1.39265774427526 0.289719626168224 9.2 9 2 increased neutrophil cell number 0.000314062267711179 0.00410094430935202 1.39234792052792 0.289655172413793 9.2 9 2 abnormal blood homeostasis 0.00131814454895498 0.0131383039140547 1.39147552208148 0.289473684210526 9.2 9 2 hyporesponsive to tactile stimuli 0.0510193190651588 0.183000081001561 1.39147552208148 0.289473684210526 9.2 9 2 decreased threshold for auditory brainstem response 0.0510193190651588 0.183000081001561 1.39147552208148 0.289473684210526 9.2 9 2 abnormal ovarian follicle morphology 0.0362927915372081 0.142845441374692 1.38866446042071 0.288888888888889 9.2 9 2 abnormal ectoderm development 0.0362927915372081 0.142845441374692 1.38866446042071 0.288888888888889 9.2 9 2 cardiomyopathy 0.0362927915372081 0.142845441374692 1.38866446042071 0.288888888888889 9.2 9 2 abnormal skin condition 0.0260209157320584 0.118983507138778 1.38661022305322 0.288461538461538 9.2 9 2 decreased body temperature 0.0260209157320584 0.118983507138778 1.38661022305322 0.288461538461538 9.2 9 2 abnormal thoracic vertebrae morphology 0.018769111513819 0.0913858291916538 1.38504343184073 0.288135593220339 9.2 9 2 abnormal spleen morphology 0.000111954829278137 0.00177380661037813 1.38129754020627 0.28735632183908 9.2 9 2 ataxia 3.43150603205761e-05 0.000682869700379465 1.38020344314473 0.287128712871287 9.2 9 2 skin lesions 0.0173362413220727 0.0877685584245696 1.3734044114051 0.285714285714286 9.2 9 2 increased fluid intake 0.0333875244767791 0.135264805110712 1.3734044114051 0.285714285714286 9.2 9 2 abnormal pancreas morphology 0.0467926642321368 0.169304366949004 1.3734044114051 0.285714285714286 9.2 9 2 ovary cysts 0.0662040528515708 0.22302900225653 1.3734044114051 0.285714285714286 9.2 9 2 increased carcinoma incidence 0.0662040528515708 0.22302900225653 1.3734044114051 0.285714285714286 9.2 9 2 straub tail 0.0949251878250335 0.277306406006777 1.3734044114051 0.285714285714286 9.2 9 2 failure of blastocyst to hatch from the zona pellucida 0.0949251878250335 0.277306406006777 1.3734044114051 0.285714285714286 9.2 9 2 enhanced coordination 0.0949251878250335 0.277306406006777 1.3734044114051 0.285714285714286 9.2 9 2 prolonged QRS complex duration 0.0949251878250335 0.277306406006777 1.3734044114051 0.285714285714286 9.2 9 2 small ears 0.138898897285625 0.353711255946986 1.3734044114051 0.285714285714286 9.2 9 2 abnormal bile salt homeostasis 0.138898897285625 0.353711255946986 1.3734044114051 0.285714285714286 9.2 9 2 decreased birth weight 0.00454559766775719 0.0337527588016299 1.36617596713454 0.284210526315789 9.2 9 2 increased spleen weight 0.0022789108128262 0.0202493571169767 1.36125039006523 0.283185840707965 9.2 9 2 abnormal mesoderm development 0.030682091434941 0.128379650873702 1.36044776601448 0.283018867924528 9.2 9 2 abnormal spermatogenesis 0.000131889527131825 0.00201273128061604 1.35847610258548 0.282608695652174 9.2 9 2 cardiac fibrosis 0.00783807311222679 0.0482353056221856 1.35724671244739 0.282352941176471 9.2 9 2 abnormal heart looping 0.0604069171772374 0.20654598828643 1.35579666254093 0.282051282051282 9.2 9 2 acanthosis 0.0604069171772374 0.20654598828643 1.35579666254093 0.282051282051282 9.2 9 2 abnormal lens fiber morphology 0.0604069171772374 0.20654598828643 1.35579666254093 0.282051282051282 9.2 9 2 abnormal long term potentiation 0.0860915433546731 0.254640563727407 1.35194496747689 0.28125 9.2 9 2 increased fatty acid level 0.0860915433546731 0.254640563727407 1.35194496747689 0.28125 9.2 9 2 impaired natural killer cell mediated cytotoxicity 0.028174418741648 0.124802435469392 1.34930959716992 0.280701754385965 9.2 9 2 abnormal excitatory postsynaptic potential 0.00990529057313576 0.0558716786863383 1.34828115997695 0.280487804878049 9.2 9 2 limb grasping 0.000191188010827531 0.00276929186030867 1.34699278810884 0.28021978021978 9.2 9 2 short stride length 0.0392540420385993 0.148395789621605 1.34593632317699 0.28 9.2 9 2 abnormal nest building behavior 0.124758778161905 0.341217658799052 1.34593632317699 0.28 9.2 9 2 weight loss 0.000257300853756166 0.00342427087277303 1.34593632317699 0.28 9.2 9 2 abnormal hepatocyte morphology 0.0033328677585137 0.0269172355496845 1.34247187961669 0.279279279279279 9.2 9 2 abnormal myocardial fiber morphology 0.00617008750236324 0.0399170160263422 1.33800739049259 0.278350515463918 9.2 9 2 underdeveloped hair follicles 0.185708953101265 0.388357310499704 1.33525428886607 0.277777777777778 9.2 9 2 cortical renal glomerulopathies 0.185708953101265 0.388357310499704 1.33525428886607 0.277777777777778 9.2 9 2 absent spleen 0.185708953101265 0.388357310499704 1.33525428886607 0.277777777777778 9.2 9 2 abnormal retinal rod cell morphology 0.185708953101265 0.388357310499704 1.33525428886607 0.277777777777778 9.2 9 2 abnormal Peyer's patch follicle morphology 0.185708953101265 0.388357310499704 1.33525428886607 0.277777777777778 9.2 9 2 increased susceptibility to autoimmune disorder 0.185708953101265 0.388357310499704 1.33525428886607 0.277777777777778 9.2 9 2 atrioventricular block 0.185708953101265 0.388357310499704 1.33525428886607 0.277777777777778 9.2 9 2 hyperactivity 2.58863533635812e-07 1.0913949829137e-05 1.33453447523325 0.277628032345013 9.2 9 2 increased or absent threshold for auditory brainstem response 5.94835940187112e-06 0.000159962637969237 1.33063403181117 0.27681660899654 9.2 9 2 abnormal coat/hair pigmentation 0.00386196733018489 0.0295134984142394 1.33048552354869 0.276785714285714 9.2 9 2 hepatic necrosis 0.050241769794685 0.180732324460273 1.32957235572195 0.276595744680851 9.2 9 2 abnormal innervation 0.050241769794685 0.180732324460273 1.32957235572195 0.276595744680851 9.2 9 2 increased systemic arterial blood pressure 0.050241769794685 0.180732324460273 1.32957235572195 0.276595744680851 9.2 9 2 decreased granulocyte number 0.112223793940347 0.309658000473227 1.32604563859802 0.275862068965517 9.2 9 2 absent long term depression 0.112223793940347 0.309658000473227 1.32604563859802 0.275862068965517 9.2 9 2 enlarged epididymis 0.112223793940347 0.309658000473227 1.32604563859802 0.275862068965517 9.2 9 2 polychromatophilia 0.112223793940347 0.309658000473227 1.32604563859802 0.275862068965517 9.2 9 2 abnormal social investigation 0.0145206318371034 0.0770150782405005 1.3219017459774 0.275 9.2 9 2 decreased circulating phosphate level 0.0708591337719203 0.232076491451813 1.3219017459774 0.275 9.2 9 2 abnormal cued conditioning behavior 0.0458178082189439 0.166260828511485 1.31954541487941 0.274509803921569 9.2 9 2 abnormal dendritic spine morphology 0.0458178082189439 0.166260828511485 1.31954541487941 0.274509803921569 9.2 9 2 male infertility 6.04811914184716e-09 3.85761445265251e-07 1.31879588610072 0.274353876739563 9.2 9 2 abnormal enzyme/coenzyme activity 0.000967048353849209 0.0100649907121335 1.31654371921317 0.273885350318471 9.2 9 2 alopecia 0.0089699051885913 0.0537653955581225 1.31557685724067 0.273684210526316 9.2 9 2 reduced fertility 0.0019074345744756 0.0173676369741376 1.31412076774732 0.273381294964029 9.2 9 2 cataract 0.00378699078365591 0.0291320853797608 1.31097693815941 0.272727272727273 9.2 9 2 abnormal CNS synaptic transmission 0.00824894052160935 0.0500250778620736 1.31097693815941 0.272727272727273 9.2 9 2 hypertension 0.0643302098724664 0.219207393229808 1.31097693815941 0.272727272727273 9.2 9 2 abnormal circadian rhythm 0.0643302098724664 0.219207393229808 1.31097693815941 0.272727272727273 9.2 9 2 embryonic lethality, incomplete penetrance 0.0643302098724664 0.219207393229808 1.31097693815941 0.272727272727273 9.2 9 2 absent vibrissae 0.101100622262473 0.290991249729659 1.31097693815941 0.272727272727273 9.2 9 2 decreased brown adipose tissue amount 0.101100622262473 0.290991249729659 1.31097693815941 0.272727272727273 9.2 9 2 decreased systemic arterial blood pressure 0.101100622262473 0.290991249729659 1.31097693815941 0.272727272727273 9.2 9 2 abnormal T cell subpopulation ratio 0.101100622262473 0.290991249729659 1.31097693815941 0.272727272727273 9.2 9 2 myeloid hyperplasia 0.101100622262473 0.290991249729659 1.31097693815941 0.272727272727273 9.2 9 2 intestinal ulcer 0.1646972521169 0.362648150447024 1.31097693815941 0.272727272727273 9.2 9 2 abnormal facial nerve morphology 0.1646972521169 0.362648150447024 1.31097693815941 0.272727272727273 9.2 9 2 abnormal tail movements 0.1646972521169 0.362648150447024 1.31097693815941 0.272727272727273 9.2 9 2 intestinal inflammation 0.1646972521169 0.362648150447024 1.31097693815941 0.272727272727273 9.2 9 2 abnormal lysosome physiology 0.1646972521169 0.362648150447024 1.31097693815941 0.272727272727273 9.2 9 2 decreased cardiac output 0.1646972521169 0.362648150447024 1.31097693815941 0.272727272727273 9.2 9 2 parakeratosis 0.1646972521169 0.362648150447024 1.31097693815941 0.272727272727273 9.2 9 2 prolonged PR interval 0.1646972521169 0.362648150447024 1.31097693815941 0.272727272727273 9.2 9 2 decreased circulating estradiol level 0.1646972521169 0.362648150447024 1.31097693815941 0.272727272727273 9.2 9 2 abnormal mesenteric lymph node morphology 0.1646972521169 0.362648150447024 1.31097693815941 0.272727272727273 9.2 9 2 rough coat 0.1646972521169 0.362648150447024 1.31097693815941 0.272727272727273 9.2 9 2 increased mammary gland tumor incidence 0.1646972521169 0.362648150447024 1.31097693815941 0.272727272727273 9.2 9 2 abnormal cytokine secretion 0.00120348116954145 0.0120955935726641 1.31097693815941 0.272727272727273 9.2 9 2 increased white adipose tissue amount 0.0912105876988546 0.26818715945733 1.29916633511293 0.27027027027027 9.2 9 2 decreased circulating chloride level 0.0912105876988546 0.26818715945733 1.29916633511293 0.27027027027027 9.2 9 2 increased insulin secretion 0.0912105876988546 0.26818715945733 1.29916633511293 0.27027027027027 9.2 9 2 skin inflammation 0.0912105876988546 0.26818715945733 1.29916633511293 0.27027027027027 9.2 9 2 enlarged liver 0.00948599903429505 0.0554044657526653 1.29786716877782 0.27 9.2 9 2 abnormal hair follicle morphology 0.0347853396244567 0.137346876691803 1.29710416632704 0.26984126984127 9.2 9 2 increased circulating glucose level 0.00250921624602904 0.0215230186620595 1.29548075685729 0.269503546099291 9.2 9 2 increased rib number 0.0210794674971135 0.100450527584425 1.29416954151634 0.269230769230769 9.2 9 2 abnormal hair growth 0.0531114001877963 0.187238608972362 1.29416954151634 0.269230769230769 9.2 9 2 increased susceptibility to otitis media 0.14668952945227 0.362173900260568 1.29416954151634 0.269230769230769 9.2 9 2 abnormal nerve conduction 0.14668952945227 0.362173900260568 1.29416954151634 0.269230769230769 9.2 9 2 increased circulating triglyceride level 0.00231030061536679 0.0202493571169767 1.29289449763307 0.268965517241379 9.2 9 2 increased total body fat amount 0.003387490846559 0.0272309969521429 1.29141011818688 0.26865671641791 9.2 9 2 thick ventricular wall 0.0823971667523096 0.244440014664723 1.28966023997796 0.268292682926829 9.2 9 2 abnormal cholesterol homeostasis 0.0823971667523096 0.244440014664723 1.28966023997796 0.268292682926829 9.2 9 2 decreased B cell number 0.000420000038031799 0.00519776166469702 1.28339975337612 0.266990291262136 9.2 9 2 lethality at weaning, complete penetrance 0.0745256347216511 0.234164173588701 1.28184411731142 0.266666666666667 9.2 9 2 salivary gland inflammation 0.131101704868284 0.353711255946986 1.28184411731142 0.266666666666667 9.2 9 2 disorganized myocardium 0.131101704868284 0.353711255946986 1.28184411731142 0.266666666666667 9.2 9 2 abnormal spleen marginal zone morphology 0.131101704868284 0.353711255946986 1.28184411731142 0.266666666666667 9.2 9 2 abnormal cellular respiration 0.131101704868284 0.353711255946986 1.28184411731142 0.266666666666667 9.2 9 2 abnormal immune system physiology 0.00568608377826095 0.0370750547796176 1.27925975417168 0.266129032258065 9.2 9 2 decreased lymphocyte cell number 0.00522171823930085 0.0351613504044123 1.27683691372818 0.265625 9.2 9 2 abnormal epidermis stratum corneum morphology 0.0674805562844066 0.22302900225653 1.27530409630473 0.26530612244898 9.2 9 2 increased sarcoma incidence 0.0674805562844066 0.22302900225653 1.27530409630473 0.26530612244898 9.2 9 2 abnormal lipid level 0.0220949610807987 0.104447042279846 1.2741221647975 0.265060240963855 9.2 9 2 abnormal oocyte morphology 0.11750275414154 0.321549065926383 1.27241879291943 0.264705882352941 9.2 9 2 abnormal nervous system development 0.11750275414154 0.321549065926383 1.27241879291943 0.264705882352941 9.2 9 2 increased susceptibility to weight gain 0.11750275414154 0.321549065926383 1.27241879291943 0.264705882352941 9.2 9 2 abnormal skin physiology 0.11750275414154 0.321549065926383 1.27241879291943 0.264705882352941 9.2 9 2 abnormal coat/ hair morphology 0.0611629469195904 0.208843967690434 1.26975124828018 0.264150943396226 9.2 9 2 abnormal pancreatic islet morphology 0.0611629469195904 0.208843967690434 1.26975124828018 0.264150943396226 9.2 9 2 abnormal locomotor activation 0.018462686666956 0.0905836944458641 1.26775791822009 0.263736263736264 9.2 9 2 decreased neuron apoptosis 0.105564612210889 0.292744674330642 1.2649777473468 0.263157894736842 9.2 9 2 decreased total retina thickness 0.105564612210889 0.292744674330642 1.2649777473468 0.263157894736842 9.2 9 2 abnormal neurotransmitter level 0.218588515468452 0.431025709257055 1.2649777473468 0.263157894736842 9.2 9 2 eyelids fail to open 0.218588515468452 0.431025709257055 1.2649777473468 0.263157894736842 9.2 9 2 increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 0.218588515468452 0.431025709257055 1.2649777473468 0.263157894736842 9.2 9 2 thin interventricular septum 0.218588515468452 0.431025709257055 1.2649777473468 0.263157894736842 9.2 9 2 abnormal posture 0.0276190644481771 0.124802435469392 1.26181530297843 0.2625 9.2 9 2 abnormal maternal nurturing 0.0503812279090034 0.180972280756167 1.26083027932271 0.262295081967213 9.2 9 2 abnormal male meiosis 0.0503812279090034 0.180972280756167 1.26083027932271 0.262295081967213 9.2 9 2 abnormal nervous system electrophysiology 0.0252021578336267 0.115664884891414 1.258954043788 0.261904761904762 9.2 9 2 abnormal spleen white pulp morphology 0.0950310224852745 0.277452662479014 1.258954043788 0.261904761904762 9.2 9 2 hyperglycemia 0.0230056657492804 0.10797470481384 1.25635289906943 0.261363636363636 9.2 9 2 abnormal sacral vertebrae morphology 0.192336165988511 0.396548871028944 1.25397794084813 0.260869565217391 9.2 9 2 increased susceptibility to age related obesity 0.192336165988511 0.396548871028944 1.25397794084813 0.260869565217391 9.2 9 2 abnormal lens development 0.192336165988511 0.396548871028944 1.25397794084813 0.260869565217391 9.2 9 2 decreased oocyte number 0.0773979802086093 0.234164173588701 1.24979801437864 0.26 9.2 9 2 abnormal cochlea morphology 0.0699956096878765 0.229752200198328 1.24623733627499 0.259259259259259 9.2 9 2 abnormal trigeminal ganglion morphology 0.170291968401471 0.362648150447024 1.24623733627499 0.259259259259259 9.2 9 2 cryptorchism 0.170291968401471 0.362648150447024 1.24623733627499 0.259259259259259 9.2 9 2 abnormal gait 7.74988865468294e-05 0.00132950676058785 1.24450885175866 0.258899676375405 9.2 9 2 abnormal cranial ganglia morphology 0.151486774200982 0.362648150447024 1.24049430707557 0.258064516129032 9.2 9 2 increased lung adenoma incidence 0.151486774200982 0.362648150447024 1.24049430707557 0.258064516129032 9.2 9 2 decreased susceptibility to bacterial infection induced morbidity/mortality 0.151486774200982 0.362648150447024 1.24049430707557 0.258064516129032 9.2 9 2 abnormal action potential 0.047323189095267 0.170975211146662 1.23606397026459 0.257142857142857 9.2 9 2 decreased circulating thyroxine level 0.135259996895761 0.353711255946986 1.23606397026459 0.257142857142857 9.2 9 2 abnormal double-strand DNA break repair 0.10875925213242 0.30126797291692 1.22967604276968 0.255813953488372 9.2 9 2 increased susceptibility to parasitic infection 0.0295226333203958 0.124802435469392 1.22843394575678 0.255555555555556 9.2 9 2 increased cellular sensitivity to gamma-irradiation 0.0978537515379267 0.285358976495419 1.22729755912796 0.25531914893617 9.2 9 2 syndactyly 0.0719856007701003 0.234164173588701 1.22209714574182 0.254237288135593 9.2 9 2 abnormal CD4-positive, alpha-beta T cell physiology 0.0535509281140235 0.1877490256288 1.21865461857072 0.253521126760563 9.2 9 2 abnormal response to infection 0.0441688001881772 0.16062849483639 1.21694061770072 0.253164556962025 9.2 9 2 increased thermal nociceptive threshold 0.0332634976296475 0.13520089927083 1.21493467162759 0.252747252747253 9.2 9 2 increased T cell proliferation 0.0229706455089383 0.107912144860215 1.21295997082039 0.252336448598131 9.2 9 2 abnormal spatial learning 0.00657449662843516 0.0414551593491317 1.20910142967258 0.251533742331288 9.2 9 2 abnormal inflammatory response 0.0603305494200449 0.20654598828643 1.20172885997946 0.25 9.2 9 2 abnormal brain wave pattern 0.0998984976143419 0.289988831932233 1.20172885997946 0.25 9.2 9 2 abnormal female meiosis 0.0998984976143419 0.289988831932233 1.20172885997946 0.25 9.2 9 2 abnormal kidney physiology 0.11099317997957 0.307114054726564 1.20172885997946 0.25 9.2 9 2 abnormal phalanx morphology 0.11099317997957 0.307114054726564 1.20172885997946 0.25 9.2 9 2 abnormal startle reflex 0.221572898942234 0.435873931292059 1.20172885997946 0.25 9.2 9 2 abnormal vasodilation 0.221572898942234 0.435873931292059 1.20172885997946 0.25 9.2 9 2 abnormal impulse conducting system conduction 0.221572898942234 0.435873931292059 1.20172885997946 0.25 9.2 9 2 increased hemangiosarcoma incidence 0.221572898942234 0.435873931292059 1.20172885997946 0.25 9.2 9 2 arrest of spermatogenesis 0.0451445853693849 0.164057203953754 1.20172885997946 0.25 9.2 9 2 enhanced long term potentiation 0.0900695298952078 0.265617019104125 1.20172885997946 0.25 9.2 9 2 abnormal female reproductive system morphology 0.13789526366004 0.353711255946986 1.20172885997946 0.25 9.2 9 2 abnormal pancreatic beta cell morphology 0.13789526366004 0.353711255946986 1.20172885997946 0.25 9.2 9 2 increased susceptibility to weight loss 0.13789526366004 0.353711255946986 1.20172885997946 0.25 9.2 9 2 abnormal stria vascularis morphology 0.195414228593617 0.401895736772734 1.20172885997946 0.25 9.2 9 2 abnormal mitotic spindle morphology 0.195414228593617 0.401895736772734 1.20172885997946 0.25 9.2 9 2 small gonad 0.253066041052529 0.487607883127936 1.20172885997946 0.25 9.2 9 2 abnormal trachea morphology 0.253066041052529 0.487607883127936 1.20172885997946 0.25 9.2 9 2 decreased circulating VLDL cholesterol level 0.253066041052529 0.487607883127936 1.20172885997946 0.25 9.2 9 2 spleen hypoplasia 0.0315551957561519 0.130911710381496 1.19028382321775 0.247619047619048 9.2 9 2 increased circulating HDL cholesterol level 0.0315551957561519 0.130911710381496 1.19028382321775 0.247619047619048 9.2 9 2 decreased IgM level 0.0380350784133001 0.14669511663031 1.18933990266008 0.247422680412371 9.2 9 2 increased exploration in new environment 0.0556756626345094 0.194649628676517 1.18689270121428 0.246913580246914 9.2 9 2 decreased monocyte cell number 0.0826033400238347 0.244905611810833 1.18324072367208 0.246153846153846 9.2 9 2 decreased urine osmolality 0.125105382259083 0.341789827973058 1.17720378120437 0.244897959183673 9.2 9 2 decreased circulating creatinine level 0.125105382259083 0.341789827973058 1.17720378120437 0.244897959183673 9.2 9 2 abnormal autopod morphology 0.139435882291765 0.353711255946986 1.17502377420214 0.244444444444444 9.2 9 2 decreased osteoclast cell number 0.139435882291765 0.353711255946986 1.17502377420214 0.244444444444444 9.2 9 2 thick epidermis 0.0835178460465091 0.247469496177119 1.16739374969433 0.242857142857143 9.2 9 2 abnormal motor coordination/ balance 0.0471462734376405 0.170459818569957 1.16531283391948 0.242424242424242 9.2 9 2 dermatitis 0.113404537908448 0.312569294235196 1.16028993377327 0.241379310344828 9.2 9 2 abnormal circulating glucose level 0.22188391234693 0.436140839164747 1.16028993377327 0.241379310344828 9.2 9 2 abnormal outer ear morphology 0.22188391234693 0.436140839164747 1.16028993377327 0.241379310344828 9.2 9 2 testicular atrophy 0.140170877643443 0.354705043884095 1.15365970558028 0.24 9.2 9 2 abnormal inner ear vestibule morphology 0.252145779188654 0.486399864855973 1.15365970558028 0.24 9.2 9 2 abnormal feces composition 0.252145779188654 0.486399864855973 1.15365970558028 0.24 9.2 9 2 increased cellular sensitivity to ionizing radiation 0.252145779188654 0.486399864855973 1.15365970558028 0.24 9.2 9 2 decreased acute inflammation 0.252145779188654 0.486399864855973 1.15365970558028 0.24 9.2 9 2 decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 0.252145779188654 0.486399864855973 1.15365970558028 0.24 9.2 9 2 increased liver glycogen level 0.252145779188654 0.486399864855973 1.15365970558028 0.24 9.2 9 2 abnormal inner ear morphology 0.156325087878296 0.362648150447024 1.14947977911079 0.239130434782609 9.2 9 2 maternal effect 0.102812191880666 0.290991249729659 1.14792010505501 0.238805970149254 9.2 9 2 disheveled coat 0.174787517153411 0.366906286007688 1.14450367617091 0.238095238095238 9.2 9 2 abnormal vibrissa morphology 0.174787517153411 0.366906286007688 1.14450367617091 0.238095238095238 9.2 9 2 abnormal salivary gland morphology 0.288743273479686 0.532638693130574 1.14450367617091 0.238095238095238 9.2 9 2 hypoalgesia 0.288743273479686 0.532638693130574 1.14450367617091 0.238095238095238 9.2 9 2 abnormal embryonic/fetal subventricular zone morphology 0.288743273479686 0.532638693130574 1.14450367617091 0.238095238095238 9.2 9 2 abnormal stapes morphology 0.288743273479686 0.532638693130574 1.14450367617091 0.238095238095238 9.2 9 2 decreased vocalization 0.288743273479686 0.532638693130574 1.14450367617091 0.238095238095238 9.2 9 2 increased grooming behavior 0.196025760960885 0.402986843297688 1.13847997261212 0.236842105263158 9.2 9 2 increased circulating calcium level 0.14030191704053 0.354856145031336 1.13618001307149 0.236363636363636 9.2 9 2 impaired hematopoiesis 0.156161386685208 0.362648150447024 1.13103892703949 0.235294117647059 9.2 9 2 abnormal brown adipose tissue morphology 0.220655472163571 0.43475682139159 1.13103892703949 0.235294117647059 9.2 9 2 decreased cytotoxic T cell cytolysis 0.220655472163571 0.43475682139159 1.13103892703949 0.235294117647059 9.2 9 2 polyuria 0.102994799310831 0.290991249729659 1.12369451842235 0.233766233766234 9.2 9 2 abnormal synaptic transmission 0.249513279840431 0.48338339844476 1.1216136026475 0.233333333333333 9.2 9 2 abnormal optic cup morphology 0.249513279840431 0.48338339844476 1.1216136026475 0.233333333333333 9.2 9 2 abnormal fat pad morphology 0.249513279840431 0.48338339844476 1.1216136026475 0.233333333333333 9.2 9 2 abnormal homeostasis 0.194796082311288 0.400955941042059 1.1178873116088 0.232558139534884 9.2 9 2 impaired macrophage phagocytosis 0.194796082311288 0.400955941042059 1.1178873116088 0.232558139534884 9.2 9 2 abnormal axon guidance 0.194796082311288 0.400955941042059 1.1178873116088 0.232558139534884 9.2 9 2 hyperkeratosis 0.125807338162316 0.342375863466117 1.11464705853167 0.231884057971014 9.2 9 2 abnormal eye electrophysiology 0.0579326939821296 0.199043613647165 1.11234406874132 0.231404958677686 9.2 9 2 abnormal excitatory postsynaptic currents 0.113336880266099 0.312555975234947 1.10928817844258 0.230769230769231 9.2 9 2 decreased IgA level 0.173040253406469 0.363545295902526 1.10928817844258 0.230769230769231 9.2 9 2 decreased B-1 B cell number 0.218492619892748 0.431025709257055 1.10928817844258 0.230769230769231 9.2 9 2 abnormal ocular fundus morphology 0.28378265410957 0.53215933064271 1.10928817844258 0.230769230769231 9.2 9 2 decreased circulating glycerol level 0.28378265410957 0.53215933064271 1.10928817844258 0.230769230769231 9.2 9 2 abnormal humoral immune response 0.0837690904278508 0.248066205284856 1.09872352912408 0.228571428571429 9.2 9 2 dehydration 0.138337558048481 0.353711255946986 1.09872352912408 0.228571428571429 9.2 9 2 decreased triglyceride level 0.245957835205885 0.477052721305761 1.09872352912408 0.228571428571429 9.2 9 2 teratozoospermia 0.111935198800065 0.309548423585505 1.09248078179951 0.227272727272727 9.2 9 2 abnormal gametogenesis 0.215745243907037 0.426263935042697 1.09248078179951 0.227272727272727 9.2 9 2 abnormal long bone epiphysis morphology 0.325227397409917 0.549407912432712 1.09248078179951 0.227272727272727 9.2 9 2 increased body size 0.325227397409917 0.549407912432712 1.09248078179951 0.227272727272727 9.2 9 2 increased coping response 0.325227397409917 0.549407912432712 1.09248078179951 0.227272727272727 9.2 9 2 aphakia 0.325227397409917 0.549407912432712 1.09248078179951 0.227272727272727 9.2 9 2 decreased IgG level 0.0906144326769378 0.267065641331615 1.08263861259411 0.225225225225225 9.2 9 2 increased anxiety-related response 0.0731223314269253 0.234164173588701 1.07204588947808 0.223021582733813 9.2 9 2 increased susceptibility to bacterial infection induced morbidity/mortality 0.165399475461439 0.362648150447024 1.06820343109285 0.222222222222222 9.2 9 2 polyphagia 0.209277963704881 0.415631884004705 1.06820343109285 0.222222222222222 9.2 9 2 abnormal neuronal precursor proliferation 0.209277963704881 0.415631884004705 1.06820343109285 0.222222222222222 9.2 9 2 increased circulating corticosterone level 0.237547918654258 0.466395160132559 1.06820343109285 0.222222222222222 9.2 9 2 wrinkled skin 0.316208564311884 0.534898880466379 1.06820343109285 0.222222222222222 9.2 9 2 decreased startle reflex 0.0973552819255815 0.284071863683148 1.06820343109285 0.222222222222222 9.2 9 2 increased circulating cholesterol level 0.0539102466930027 0.188875688237809 1.06516876225452 0.221590909090909 9.2 9 2 increased bone mineral density 0.1065427449925 0.295292566204839 1.06347686723846 0.221238938053097 9.2 9 2 abnormal inhibitory postsynaptic currents 0.182781921969555 0.383364275631761 1.06034899409952 0.220588235294118 9.2 9 2 increased circulating chloride level 0.233064464211916 0.457936694097267 1.05752139678192 0.22 9.2 9 2 small ovary 0.144041699664609 0.359316911799536 1.05646493185007 0.21978021978022 9.2 9 2 abnormal lens morphology 0.102658154214322 0.290991249729659 1.05151275248203 0.21875 9.2 9 2 abnormal retinal pigmentation 0.158265255290674 0.362648150447024 1.04978613055677 0.218390804597701 9.2 9 2 abnormal epidermal layer morphology 0.198608195249344 0.407790248190461 1.04498161737344 0.217391304347826 9.2 9 2 abnormal coat appearance 0.198608195249344 0.407790248190461 1.04498161737344 0.217391304347826 9.2 9 2 abnormal food intake 0.198608195249344 0.407790248190461 1.04498161737344 0.217391304347826 9.2 9 2 decreased epididymis weight 0.362141628360308 0.596574371222693 1.04498161737344 0.217391304347826 9.2 9 2 abnormal B cell morphology 0.362141628360308 0.596574371222693 1.04498161737344 0.217391304347826 9.2 9 2 abnormal hepatocyte physiology 0.362141628360308 0.596574371222693 1.04498161737344 0.217391304347826 9.2 9 2 abnormal vocalization 0.299048691210749 0.532638693130574 1.03933306809034 0.216216216216216 9.2 9 2 abnormal breathing pattern 0.299048691210749 0.532638693130574 1.03933306809034 0.216216216216216 9.2 9 2 abnormal respiratory electron transport chain 0.299048691210749 0.532638693130574 1.03933306809034 0.216216216216216 9.2 9 2 decreased exploration in new environment 0.187827499277962 0.392622608784816 1.03005330855382 0.214285714285714 9.2 9 2 increased circulating luteinizing hormone level 0.349152474053229 0.576130533470917 1.03005330855382 0.214285714285714 9.2 9 2 abnormal retinal inner nuclear layer morphology 0.349152474053229 0.576130533470917 1.03005330855382 0.214285714285714 9.2 9 2 deafness 0.177400836962878 0.372234991096718 1.01964872967954 0.212121212121212 9.2 9 2 diarrhea 0.337357025944551 0.56873981839178 1.01964872967954 0.212121212121212 9.2 9 2 impaired righting response 0.194065387352635 0.399948343860547 1.01198219787744 0.210526315789474 9.2 9 2 increased eosinophil cell number 0.262242229919982 0.505092951549327 1.0079016244989 0.209677419354839 9.2 9 2 retinal degeneration 0.207769157380608 0.41296506510928 1.00144071664955 0.208333333333333 9.2 9 2 abnormal lymph node morphology 0.307107623431738 0.532638693130574 1.00144071664955 0.208333333333333 9.2 9 2 increased stereotypic behavior 0.399133399259801 0.650192750922563 1.00144071664955 0.208333333333333 9.2 9 2 abnormal retinal ganglion layer morphology 0.399133399259801 0.650192750922563 1.00144071664955 0.208333333333333 9.2 9 2 hypopigmentation 0.399133399259801 0.650192750922563 1.00144071664955 0.208333333333333 9.2 9 2 abnormal cellular extravasation 0.399133399259801 0.650192750922563 1.00144071664955 0.208333333333333 9.2 9 2 cochlear ganglion degeneration 0.290020112192632 0.532638693130574 0.994534228948518 0.206896551724138 9.2 9 2 focal hair loss 0.382352968411394 0.626963090918485 0.994534228948518 0.206896551724138 9.2 9 2 decreased retinal photoreceptor cell number 0.382352968411394 0.626963090918485 0.994534228948518 0.206896551724138 9.2 9 2 abnormal CD8-positive, alpha-beta T cell physiology 0.382352968411394 0.626963090918485 0.994534228948518 0.206896551724138 9.2 9 2 increased retinal apoptosis 0.382352968411394 0.626963090918485 0.994534228948518 0.206896551724138 9.2 9 2 abnormal direction of heart looping 0.367612984332212 0.605387155595087 0.989659061159555 0.205882352941176 9.2 9 2 small lens 0.354399886215349 0.584595303024324 0.986033936393402 0.205128205128205 9.2 9 2 cochlear hair cell degeneration 0.342382415248686 0.570964050137402 0.983232703619557 0.204545454545455 9.2 9 2 increased startle reflex 0.264355532430231 0.508966243746285 0.972185145151922 0.202247191011236 9.2 9 2 abnormal thyroid gland morphology 0.435880304277587 0.659721482744446 0.961383087983567 0.2 9.2 9 2 abnormal eye physiology 0.333410640476985 0.563040711599797 0.961383087983567 0.2 9.2 9 2 abnormal response to new environment 0.415562890554135 0.655221638922363 0.961383087983567 0.2 9.2 9 2 abnormal estrous cycle 0.415562890554135 0.655221638922363 0.961383087983567 0.2 9.2 9 2 impaired behavioral response to xenobiotic 0.398026771613794 0.649240389763483 0.961383087983567 0.2 9.2 9 2 impaired adaptive thermogenesis 0.398026771613794 0.649240389763483 0.961383087983567 0.2 9.2 9 2 scaly skin 0.410750194407205 0.655221638922363 0.937934719983968 0.195121951219512 9.2 9 2 absent mature ovarian follicles 0.448552941730662 0.676842852626643 0.930370730306678 0.193548387096774 9.2 9 2 abnormal CD8-positive, alpha beta T cell morphology 0.448552941730662 0.676842852626643 0.930370730306678 0.193548387096774 9.2 9 2 increased liver weight 0.342213339746403 0.570964050137402 0.928608664529582 0.193181818181818 9.2 9 2 abnormal circulating amino acid level 0.391238424258399 0.64111039548272 0.927650348054319 0.192982456140351 9.2 9 2 abnormal leukocyte migration 0.405633520819133 0.655221638922363 0.924406815368815 0.192307692307692 9.2 9 2 abnormal erythrocyte osmotic lysis 0.472094030508068 0.707219722718679 0.924406815368815 0.192307692307692 9.2 9 2 decreased Peyer's patch number 0.472094030508068 0.707219722718679 0.924406815368815 0.192307692307692 9.2 9 2 decreased rib number 0.360596433140499 0.594619574038443 0.918174859310149 0.191011235955056 9.2 9 2 abnormal chromosome morphology 0.458597987406219 0.69179047524134 0.90941643457905 0.189189189189189 9.2 9 2 abnormal urine homeostasis 0.386190757177714 0.633047452045841 0.901296644984594 0.1875 9.2 9 2 abnormal hair shaft morphology 0.447801199426028 0.676118654672076 0.901296644984594 0.1875 9.2 9 2 polydipsia 0.481114303211766 0.714703988796218 0.901296644984594 0.1875 9.2 9 2 abnormal serotonin level 0.481114303211766 0.714703988796218 0.901296644984594 0.1875 9.2 9 2 impaired swimming 0.468290487239117 0.705342165914202 0.873984625439607 0.181818181818182 9.2 9 2 abnormal amino acid level 0.494584709755851 0.733400575569407 0.873984625439607 0.181818181818182 9.2 9 2 cochlear outer hair cell degeneration 0.473761390177394 0.707219722718679 0.867915287762943 0.180555555555556 9.2 9 2 abnormal leukocyte adhesion 0.517738991940082 0.755962055195237 0.862779694344227 0.179487179487179 9.2 9 2 increased autoantibody level 0.517738991940082 0.755962055195237 0.862779694344227 0.179487179487179 9.2 9 2 reddish skin 0.541950821965574 0.765097996390105 0.858377757128185 0.178571428571429 9.2 9 2 irregular heartbeat 0.521826584427972 0.755962055195237 0.854562744874282 0.177777777777778 9.2 9 2 abnormal metabolism 0.521826584427972 0.755962055195237 0.854562744874282 0.177777777777778 9.2 9 2 increased susceptibility to pharmacologically induced seizures 0.49162158733067 0.729224030104377 0.851224609152117 0.177083333333333 9.2 9 2 cochlear inner hair cell degeneration 0.525481517913245 0.755962055195237 0.848279195279618 0.176470588235294 9.2 9 2 circling 0.50319797185055 0.745284284000145 0.848279195279618 0.176470588235294 9.2 9 2 abnormal retinal photoreceptor morphology 0.54422766064695 0.767876520623533 0.848279195279618 0.176470588235294 9.2 9 2 abnormal vision 0.54422766064695 0.767876520623533 0.848279195279618 0.176470588235294 9.2 9 2 stomach inflammation 0.575200374789362 0.811347282273058 0.828778524123765 0.172413793103448 9.2 9 2 arrested T cell differentiation 0.607127871636407 0.841554788954002 0.801152573319639 0.166666666666667 9.2 9 2 head tilt 0.603688747451637 0.841554788954002 0.801152573319639 0.166666666666667 9.2 9 2 abnormal intestinal mucosa morphology 0.627596022422299 0.86227291122644 0.782521118126159 0.162790697674419 9.2 9 2 abnormal photoreceptor outer segment morphology 0.652760324818654 0.893638584472429 0.764736547259656 0.159090909090909 9.2 9 2 decreased susceptibility to parasitic infection 0.666606151807522 0.910589128292812 0.751080537487162 0.15625 9.2 9 2 decreased pancreatic beta cell number 0.719852177114443 0.965821084451012 0.706899329399682 0.147058823529412 9.2 9 2 arrested B cell differentiation 0.73160794208273 0.9733592578095 0.703451039987976 0.146341463414634 9.2 9 2 organ of Corti degeneration 0.762339931506838 1 0.686702205702548 0.142857142857143 9.2 9 2 abnormal reflex 0.76672551544732 1 0.667627144433033 0.138888888888889 9.2 9 2 abnormal retinal outer nuclear layer morphology 0.807382396590845 1 0.632488873673399 0.131578947368421 9.2 9 2 head bobbing 0.842186259078332 1 0.600864429989729 0.125 9.2 9 2 abnormal digestive system physiology 0.882282771576747 1 0.57682985279014 0.12 9.2 9 2 abnormal olfactory bulb mitral cell layer morphology 3.32556722912793e-05 0.00056080364396344 2.62784728905999 1 9.3 9 3 increased embryo size 0.00043812825682905 0.00493142099032697 2.62784728905999 1 9.3 9 3 chromatolysis 0.00043812825682905 0.00493142099032697 2.62784728905999 1 9.3 9 3 abnormal hippocampal fimbria morphology 0.00043812825682905 0.00493142099032697 2.62784728905999 1 9.3 9 3 absent parietal bone 0.00043812825682905 0.00493142099032697 2.62784728905999 1 9.3 9 3 abnormal olfactory bulb layer morphology 0.00043812825682905 0.00493142099032697 2.62784728905999 1 9.3 9 3 abnormal intestinal enteroendocrine cell morphology 0.00043812825682905 0.00493142099032697 2.62784728905999 1 9.3 9 3 abnormal hypodermis morphology 0.00159007835901825 0.0139027062146147 2.62784728905999 1 9.3 9 3 absent frontal bone 0.00159007835901825 0.0139027062146147 2.62784728905999 1 9.3 9 3 alveolitis 0.00159007835901825 0.0139027062146147 2.62784728905999 1 9.3 9 3 blind ureter 0.00159007835901825 0.0139027062146147 2.62784728905999 1 9.3 9 3 abnormal mammary gland bud morphology 0.00159007835901825 0.0139027062146147 2.62784728905999 1 9.3 9 3 decreased small intestinal villus height 0.00159007835901825 0.0139027062146147 2.62784728905999 1 9.3 9 3 adipose tissue inflammation 0.000226012279252857 0.00291298209658799 2.33586425694222 0.888888888888889 9.3 9 3 colon polyps 0.000732906044905669 0.00745645720532863 2.29936637792749 0.875 9.3 9 3 increased cardiac output 0.000732906044905669 0.00745645720532863 2.29936637792749 0.875 9.3 9 3 abnormal somite size 0.000732906044905669 0.00745645720532863 2.29936637792749 0.875 9.3 9 3 skin fibrosis 0.000732906044905669 0.00745645720532863 2.29936637792749 0.875 9.3 9 3 pulmonary artery hypoplasia 0.000732906044905669 0.00745645720532863 2.29936637792749 0.875 9.3 9 3 increased aorta wall thickness 0.000732906044905669 0.00745645720532863 2.29936637792749 0.875 9.3 9 3 increased circulating ferritin level 0.000732906044905669 0.00745645720532863 2.29936637792749 0.875 9.3 9 3 abnormal heart echocardiography feature 0.000732906044905669 0.00745645720532863 2.29936637792749 0.875 9.3 9 3 abnormal umbilical vein topology 0.000732906044905669 0.00745645720532863 2.29936637792749 0.875 9.3 9 3 midline facial cleft 9.69541965099563e-06 0.000190651038591712 2.25244053347999 0.857142857142857 9.3 9 3 mammary gland hyperplasia 0.00234262598459488 0.0185852423682732 2.25244053347999 0.857142857142857 9.3 9 3 abnormal gastrulation movements 0.00234262598459488 0.0185852423682732 2.25244053347999 0.857142857142857 9.3 9 3 abnormal brain ventricular system morphology 0.00234262598459488 0.0185852423682732 2.25244053347999 0.857142857142857 9.3 9 3 decreased mortality induced by ionizing radiation 0.00234262598459488 0.0185852423682732 2.25244053347999 0.857142857142857 9.3 9 3 skeletal muscle interstitial fibrosis 0.00234262598459488 0.0185852423682732 2.25244053347999 0.857142857142857 9.3 9 3 heart hemorrhage 0.00234262598459488 0.0185852423682732 2.25244053347999 0.857142857142857 9.3 9 3 coronary fistula 0.00234262598459488 0.0185852423682732 2.25244053347999 0.857142857142857 9.3 9 3 altered tumor pathology 0.00234262598459488 0.0185852423682732 2.25244053347999 0.857142857142857 9.3 9 3 abnormal xiphoid process morphology 2.11140392796799e-09 1.10570889912008e-07 2.22356309074307 0.846153846153846 9.3 9 3 abnormal rostral-caudal body axis extension 9.36713712209198e-05 0.00135168669311944 2.18987274088333 0.833333333333333 9.3 9 3 prenatal growth retardation 9.36713712209198e-05 0.00135168669311944 2.18987274088333 0.833333333333333 9.3 9 3 thin tail 0.00734982886996423 0.0437385151053493 2.18987274088333 0.833333333333333 9.3 9 3 abnormal lacrimal gland physiology 0.00734982886996423 0.0437385151053493 2.18987274088333 0.833333333333333 9.3 9 3 decreased posterior semicircular canal size 0.00734982886996423 0.0437385151053493 2.18987274088333 0.833333333333333 9.3 9 3 decreased liver function 0.00734982886996423 0.0437385151053493 2.18987274088333 0.833333333333333 9.3 9 3 abnormal periodontal ligament morphology 0.00734982886996423 0.0437385151053493 2.18987274088333 0.833333333333333 9.3 9 3 decreased prostate gland weight 0.00734982886996423 0.0437385151053493 2.18987274088333 0.833333333333333 9.3 9 3 abnormal aorta tunica adventitia morphology 0.00734982886996423 0.0437385151053493 2.18987274088333 0.833333333333333 9.3 9 3 thick myocardium 0.00734982886996423 0.0437385151053493 2.18987274088333 0.833333333333333 9.3 9 3 ectopic ureteric bud 0.00734982886996423 0.0437385151053493 2.18987274088333 0.833333333333333 9.3 9 3 additional anastomosis between intracranial vertebral arteries 0.00734982886996423 0.0437385151053493 2.18987274088333 0.833333333333333 9.3 9 3 abnormal bone marrow cavity morphology 4.05541636459357e-06 9.21264676431644e-05 2.16410953216705 0.823529411764706 9.3 9 3 abnormal proximal-distal axis patterning 0.000285315101535319 0.00352219014922633 2.15005687286727 0.818181818181818 9.3 9 3 abnormal radial glial cell morphology 0.000285315101535319 0.00352219014922633 2.15005687286727 0.818181818181818 9.3 9 3 pharyngeal arch hypoplasia 0.000285315101535319 0.00352219014922633 2.15005687286727 0.818181818181818 9.3 9 3 abnormal Bruch membrane morphology 0.000285315101535319 0.00352219014922633 2.15005687286727 0.818181818181818 9.3 9 3 abnormal palate development 0.000285315101535319 0.00352219014922633 2.15005687286727 0.818181818181818 9.3 9 3 abnormal pericardium morphology 1.61061869413867e-06 4.19519790750778e-05 2.10227783124799 0.8 9.3 9 3 increased skin tumor incidence 1.61061869413867e-06 4.19519790750778e-05 2.10227783124799 0.8 9.3 9 3 delayed intramembranous bone ossification 3.62043150193214e-05 0.000600092573190888 2.10227783124799 0.8 9.3 9 3 abnormal aorta wall morphology 3.62043150193214e-05 0.000600092573190888 2.10227783124799 0.8 9.3 9 3 increased cranium width 0.00085446190502816 0.00830263276858417 2.10227783124799 0.8 9.3 9 3 ketoaciduria 0.00085446190502816 0.00830263276858417 2.10227783124799 0.8 9.3 9 3 abnormal respiratory conducting tube morphology 0.00085446190502816 0.00830263276858417 2.10227783124799 0.8 9.3 9 3 decreased transitional stage T2 B cell number 0.00085446190502816 0.00830263276858417 2.10227783124799 0.8 9.3 9 3 abnormal hippocampus neuron morphology 0.00085446190502816 0.00830263276858417 2.10227783124799 0.8 9.3 9 3 premature bone ossification 0.00250703422469051 0.0193610214933862 2.04388122482444 0.777777777777778 9.3 9 3 increased neuronal precursor cell number 0.00250703422469051 0.0193610214933862 2.04388122482444 0.777777777777778 9.3 9 3 abnormal intervertebral disk development 0.00250703422469051 0.0193610214933862 2.04388122482444 0.777777777777778 9.3 9 3 decreased transitional stage T1 B cell number 0.00250703422469051 0.0193610214933862 2.04388122482444 0.777777777777778 9.3 9 3 iris coloboma 0.00250703422469051 0.0193610214933862 2.04388122482444 0.777777777777778 9.3 9 3 abnormal nasal bone morphology 2.35831728151249e-07 7.6683846245259e-06 2.02142099158461 0.769230769230769 9.3 9 3 increased cochlear inner hair cell number 0.00030484567277755 0.00369904200504466 2.02142099158461 0.769230769230769 9.3 9 3 small lung 5.32395320238179e-13 5.40544228201008e-11 2.00953027986941 0.764705882352941 9.3 9 3 abnormal cell differentiation 2.19774126199746e-10 1.40176445877402e-08 1.98690892587463 0.75609756097561 9.3 9 3 abnormal aorta elastic fiber morphology 0.000860246292478516 0.00831014622345751 1.970885466795 0.75 9.3 9 3 dilated bile duct 0.000860246292478516 0.00831014622345751 1.970885466795 0.75 9.3 9 3 persistent right dorsal aorta 0.000860246292478516 0.00831014622345751 1.970885466795 0.75 9.3 9 3 failure of vascular branching 0.0071717858036625 0.0432480416645102 1.970885466795 0.75 9.3 9 3 dry eyes 0.0071717858036625 0.0432480416645102 1.970885466795 0.75 9.3 9 3 absent eyelids 0.0071717858036625 0.0432480416645102 1.970885466795 0.75 9.3 9 3 short ureter 0.0071717858036625 0.0432480416645102 1.970885466795 0.75 9.3 9 3 tau protein deposits 0.0071717858036625 0.0432480416645102 1.970885466795 0.75 9.3 9 3 bowed fibula 0.0071717858036625 0.0432480416645102 1.970885466795 0.75 9.3 9 3 absent interparietal bone 0.0071717858036625 0.0432480416645102 1.970885466795 0.75 9.3 9 3 abnormal canal of Schlemm morphology 0.0071717858036625 0.0432480416645102 1.970885466795 0.75 9.3 9 3 enlarged inguinal lymph nodes 0.0071717858036625 0.0432480416645102 1.970885466795 0.75 9.3 9 3 abnormal olfactory bulb glomerular layer morphology 0.0071717858036625 0.0432480416645102 1.970885466795 0.75 9.3 9 3 abnormal lateral plate mesoderm morphology 0.0071717858036625 0.0432480416645102 1.970885466795 0.75 9.3 9 3 lung situs inversus 0.0071717858036625 0.0432480416645102 1.970885466795 0.75 9.3 9 3 decreased alveolar lamellar body number 0.0071717858036625 0.0432480416645102 1.970885466795 0.75 9.3 9 3 abnormal maxillary prominence morphology 0.0071717858036625 0.0432480416645102 1.970885466795 0.75 9.3 9 3 abnormal foramen magnum morphology 0.0071717858036625 0.0432480416645102 1.970885466795 0.75 9.3 9 3 abnormal kidney mesenchyme morphology 0.0071717858036625 0.0432480416645102 1.970885466795 0.75 9.3 9 3 increased cardiac stroke volume 0.0071717858036625 0.0432480416645102 1.970885466795 0.75 9.3 9 3 absent hypoglossal canal 0.0071717858036625 0.0432480416645102 1.970885466795 0.75 9.3 9 3 increased mammary adenocarcinoma incidence 1.39940619416313e-05 0.000255019993258666 1.970885466795 0.75 9.3 9 3 abnormal physiological neovascularization 1.39940619416313e-05 0.000255019993258666 1.970885466795 0.75 9.3 9 3 kidney atrophy 1.39940619416313e-05 0.000255019993258666 1.970885466795 0.75 9.3 9 3 abnormal postnatal growth/weight/body size 9.03203573813741e-08 3.18683530476834e-06 1.94969314994774 0.741935483870968 9.3 9 3 increased liver adenoma incidence 3.84320318761177e-05 0.000628945258498966 1.93630852878105 0.736842105263158 9.3 9 3 abnormal placenta size 0.000297710026689462 0.00362128944445005 1.92708801197733 0.733333333333333 9.3 9 3 ostium primum atrial septal defect 0.000297710026689462 0.00362128944445005 1.92708801197733 0.733333333333333 9.3 9 3 premature suture closure 0.00237218671434241 0.0185852423682732 1.9111616647709 0.727272727272727 9.3 9 3 abnormal ureter development 0.00237218671434241 0.0185852423682732 1.9111616647709 0.727272727272727 9.3 9 3 abnormal dorsal-ventral polarity of the somites 0.00237218671434241 0.0185852423682732 1.9111616647709 0.727272727272727 9.3 9 3 palatal shelf hypoplasia 0.00237218671434241 0.0185852423682732 1.9111616647709 0.727272727272727 9.3 9 3 aberrant origin of the right subclavian artery 0.00237218671434241 0.0185852423682732 1.9111616647709 0.727272727272727 9.3 9 3 common atrioventricular valve 0.00237218671434241 0.0185852423682732 1.9111616647709 0.727272727272727 9.3 9 3 abnormal artery morphology 8.54967386816487e-08 3.07215178995631e-06 1.8770337779 0.714285714285714 9.3 9 3 premature aging 1.74026660371282e-06 4.50928455909963e-05 1.8770337779 0.714285714285714 9.3 9 3 abnormal clavicle morphology 3.64277300710851e-05 0.000600092573190888 1.8770337779 0.714285714285714 9.3 9 3 increased muscle cell glucose uptake 3.64277300710851e-05 0.000600092573190888 1.8770337779 0.714285714285714 9.3 9 3 abnormal kidney blood vessel morphology 0.000802111926059695 0.00791767228600592 1.8770337779 0.714285714285714 9.3 9 3 increased hemangioma incidence 0.000802111926059695 0.00791767228600592 1.8770337779 0.714285714285714 9.3 9 3 spina bifida occulta 0.000802111926059695 0.00791767228600592 1.8770337779 0.714285714285714 9.3 9 3 decreased compact bone area 0.000802111926059695 0.00791767228600592 1.8770337779 0.714285714285714 9.3 9 3 abnormal renal tubule epithelial cell primary cilium morphology 0.000802111926059695 0.00791767228600592 1.8770337779 0.714285714285714 9.3 9 3 growth retardation of molars 0.0198678360833876 0.0943899634003083 1.8770337779 0.714285714285714 9.3 9 3 failure of atrioventricular cushion closure 0.0198678360833876 0.0943899634003083 1.8770337779 0.714285714285714 9.3 9 3 polyphalangy 0.0198678360833876 0.0943899634003083 1.8770337779 0.714285714285714 9.3 9 3 decreased Schwann cell number 0.0198678360833876 0.0943899634003083 1.8770337779 0.714285714285714 9.3 9 3 decreased lateral semicircular canal size 0.0198678360833876 0.0943899634003083 1.8770337779 0.714285714285714 9.3 9 3 increased cell nucleus count 0.0198678360833876 0.0943899634003083 1.8770337779 0.714285714285714 9.3 9 3 abnormal nephron morphology 0.0198678360833876 0.0943899634003083 1.8770337779 0.714285714285714 9.3 9 3 abnormal organ of Corti supporting cell morphology 0.0198678360833876 0.0943899634003083 1.8770337779 0.714285714285714 9.3 9 3 absent deltoid tuberosity 0.0198678360833876 0.0943899634003083 1.8770337779 0.714285714285714 9.3 9 3 atherosclerotic lesions 0.0198678360833876 0.0943899634003083 1.8770337779 0.714285714285714 9.3 9 3 retinal pigment epithelium atrophy 0.0198678360833876 0.0943899634003083 1.8770337779 0.714285714285714 9.3 9 3 decreased tidal volume 0.0198678360833876 0.0943899634003083 1.8770337779 0.714285714285714 9.3 9 3 abnormal spinal cord central canal morphology 0.0198678360833876 0.0943899634003083 1.8770337779 0.714285714285714 9.3 9 3 postaxial polydactyly 0.0198678360833876 0.0943899634003083 1.8770337779 0.714285714285714 9.3 9 3 decreased DN4 thymocyte number 0.0198678360833876 0.0943899634003083 1.8770337779 0.714285714285714 9.3 9 3 focal dorsal hair loss 0.0198678360833876 0.0943899634003083 1.8770337779 0.714285714285714 9.3 9 3 abnormal conotruncal ridge morphology 0.0198678360833876 0.0943899634003083 1.8770337779 0.714285714285714 9.3 9 3 abnormal aortic valve cusp morphology 0.0198678360833876 0.0943899634003083 1.8770337779 0.714285714285714 9.3 9 3 small lung saccule 0.0198678360833876 0.0943899634003083 1.8770337779 0.714285714285714 9.3 9 3 small lung lobe 0.0198678360833876 0.0943899634003083 1.8770337779 0.714285714285714 9.3 9 3 increased circulating lactate dehydrogenase level 0.0198678360833876 0.0943899634003083 1.8770337779 0.714285714285714 9.3 9 3 small tail bud 0.0198678360833876 0.0943899634003083 1.8770337779 0.714285714285714 9.3 9 3 impaired mammary gland growth during pregnancy 0.0198678360833876 0.0943899634003083 1.8770337779 0.714285714285714 9.3 9 3 embryo tumor 0.0198678360833876 0.0943899634003083 1.8770337779 0.714285714285714 9.3 9 3 decreased collagen level 0.0198678360833876 0.0943899634003083 1.8770337779 0.714285714285714 9.3 9 3 overriding aortic valve 5.64315190607039e-10 3.38249165454219e-08 1.86139182975083 0.708333333333333 9.3 9 3 abnormal adipose tissue morphology 0.000275246519880133 0.00344924795063894 1.85495102757176 0.705882352941177 9.3 9 3 hydroureter 0.000275246519880133 0.00344924795063894 1.85495102757176 0.705882352941177 9.3 9 3 abnormal maxilla morphology 7.45549036277985e-11 5.29872350783282e-09 1.84922587007925 0.703703703703704 9.3 9 3 abnormal atrioventricular cushion morphology 4.55122136471699e-06 0.000101535095468462 1.84922587007925 0.703703703703704 9.3 9 3 impaired basement membrane formation 0.00636303630390265 0.0400710197619186 1.839493102342 0.7 9.3 9 3 aneurysm 0.00636303630390265 0.0400710197619186 1.839493102342 0.7 9.3 9 3 lymphedema 0.00636303630390265 0.0400710197619186 1.839493102342 0.7 9.3 9 3 abnormal hindlimb zeugopod morphology 0.00636303630390265 0.0400710197619186 1.839493102342 0.7 9.3 9 3 increased heart rate variability 0.00636303630390265 0.0400710197619186 1.839493102342 0.7 9.3 9 3 increased susceptibility to atherosclerosis 0.00636303630390265 0.0400710197619186 1.839493102342 0.7 9.3 9 3 osteosclerosis 0.00636303630390265 0.0400710197619186 1.839493102342 0.7 9.3 9 3 protruding tongue 0.00636303630390265 0.0400710197619186 1.839493102342 0.7 9.3 9 3 increased circulating fructosamine level 0.00636303630390265 0.0400710197619186 1.839493102342 0.7 9.3 9 3 abnormal left subclavian artery morphology 0.00636303630390265 0.0400710197619186 1.839493102342 0.7 9.3 9 3 thin ventricle myocardium compact layer 0.00636303630390265 0.0400710197619186 1.839493102342 0.7 9.3 9 3 abnormal adaptive thermogenesis 0.00636303630390265 0.0400710197619186 1.839493102342 0.7 9.3 9 3 lethality during fetal growth through weaning, complete penetrance 0.00636303630390265 0.0400710197619186 1.839493102342 0.7 9.3 9 3 increased fatty acid oxidation 0.00636303630390265 0.0400710197619186 1.839493102342 0.7 9.3 9 3 abnormal blood vessel physiology 3.33664077614429e-05 0.00056080364396344 1.82806767934608 0.695652173913043 9.3 9 3 abnormal hematopoietic stem cell physiology 3.33664077614429e-05 0.00056080364396344 1.82806767934608 0.695652173913043 9.3 9 3 abnormal ureter morphology 1.17355086493478e-05 0.000221992986808006 1.81927889242615 0.692307692307692 9.3 9 3 increased foot pad pigmentation 0.00210989768680569 0.0171515375683959 1.81927889242615 0.692307692307692 9.3 9 3 abnormal tail bud morphology 0.00210989768680569 0.0171515375683959 1.81927889242615 0.692307692307692 9.3 9 3 empty decidua capsularis 0.00210989768680569 0.0171515375683959 1.81927889242615 0.692307692307692 9.3 9 3 abnormal aorta tunica media morphology 0.00210989768680569 0.0171515375683959 1.81927889242615 0.692307692307692 9.3 9 3 increased mortality induced by gamma-irradiation 4.14792937359504e-06 9.33753331838703e-05 1.81230847521379 0.689655172413793 9.3 9 3 decreased trophoblast giant cell number 4.14792937359504e-06 9.33753331838703e-05 1.81230847521379 0.689655172413793 9.3 9 3 failure of tooth eruption 0.000714556717127165 0.0074060826410576 1.80664501122875 0.6875 9.3 9 3 abnormal epicardium morphology 0.000714556717127165 0.0074060826410576 1.80664501122875 0.6875 9.3 9 3 bowed tibia 0.000714556717127165 0.0074060826410576 1.80664501122875 0.6875 9.3 9 3 increased cochlear outer hair cell number 0.000714556717127165 0.0074060826410576 1.80664501122875 0.6875 9.3 9 3 persistence of hyaloid vascular system 1.8713117388102e-07 6.20651726705383e-06 1.79800077672526 0.684210526315789 9.3 9 3 abnormal mammary gland development 6.6973969153264e-08 2.50069876688539e-06 1.79462741691902 0.682926829268293 9.3 9 3 abnormal abdominal fat pad morphology 8.51957970506699e-05 0.00125771243420499 1.79171406072272 0.681818181818182 9.3 9 3 abnormal chorion morphology 8.51957970506699e-05 0.00125771243420499 1.79171406072272 0.681818181818182 9.3 9 3 increased myocardial infarction size 8.51957970506699e-05 0.00125771243420499 1.79171406072272 0.681818181818182 9.3 9 3 rib bifurcation 1.04854591935036e-05 0.000202190540649924 1.783182089005 0.678571428571429 9.3 9 3 osteopetrosis 3.70744561539585e-06 8.65940935990346e-05 1.78015461516967 0.67741935483871 9.3 9 3 preaxial polydactyly 3.70744561539585e-06 8.65940935990346e-05 1.78015461516967 0.67741935483871 9.3 9 3 kidney cysts 9.05674196280387e-13 9.01145825298985e-11 1.7755724926081 0.675675675675676 9.3 9 3 liver hypoplasia 2.77837992163509e-09 1.38827620119461e-07 1.76874336763653 0.673076923076923 9.3 9 3 abnormal tooth development 3.26221420271327e-06 7.87840565946529e-05 1.75189819270666 0.666666666666667 9.3 9 3 abnormal type II pneumocyte morphology 2.61040832186095e-05 0.000450929909765911 1.75189819270666 0.666666666666667 9.3 9 3 abnormal fontanelle morphology 0.00181091572480016 0.015587034136472 1.75189819270666 0.666666666666667 9.3 9 3 absent incisors 0.00181091572480016 0.015587034136472 1.75189819270666 0.666666666666667 9.3 9 3 dilated ureter 0.00181091572480016 0.015587034136472 1.75189819270666 0.666666666666667 9.3 9 3 immune system phenotype 0.00181091572480016 0.015587034136472 1.75189819270666 0.666666666666667 9.3 9 3 heterochrony 0.00181091572480016 0.015587034136472 1.75189819270666 0.666666666666667 9.3 9 3 increased papilloma incidence 0.00539606755807019 0.0359376654637205 1.75189819270666 0.666666666666667 9.3 9 3 abnormal embryonic growth/weight/body size 0.00539606755807019 0.0359376654637205 1.75189819270666 0.666666666666667 9.3 9 3 increased osteosarcoma incidence 0.00539606755807019 0.0359376654637205 1.75189819270666 0.666666666666667 9.3 9 3 pale placenta 0.00539606755807019 0.0359376654637205 1.75189819270666 0.666666666666667 9.3 9 3 abnormal thymus corticomedullary boundary morphology 0.00539606755807019 0.0359376654637205 1.75189819270666 0.666666666666667 9.3 9 3 abnormal aorta elastic tissue morphology 0.00539606755807019 0.0359376654637205 1.75189819270666 0.666666666666667 9.3 9 3 decreased red blood cell distribution width 0.00539606755807019 0.0359376654637205 1.75189819270666 0.666666666666667 9.3 9 3 decreased mammary gland epithelial cell proliferation 0.00539606755807019 0.0359376654637205 1.75189819270666 0.666666666666667 9.3 9 3 embryonic lethality between implantation and placentation, incomplete penetrance 0.00539606755807019 0.0359376654637205 1.75189819270666 0.666666666666667 9.3 9 3 renal hypoplasia 1.15989040637669e-06 3.17057954490332e-05 1.75189819270666 0.666666666666667 9.3 9 3 abnormal scapula morphology 0.000213506425027588 0.00279524859082171 1.75189819270666 0.666666666666667 9.3 9 3 left pulmonary isomerism 0.000213506425027588 0.00279524859082171 1.75189819270666 0.666666666666667 9.3 9 3 abnormal tumor vascularization 0.000213506425027588 0.00279524859082171 1.75189819270666 0.666666666666667 9.3 9 3 abnormal metacarpal bone morphology 0.000618114133838331 0.00652891256018195 1.75189819270666 0.666666666666667 9.3 9 3 absent allantois 0.000618114133838331 0.00652891256018195 1.75189819270666 0.666666666666667 9.3 9 3 decreased cellular sensitivity to gamma-irradiation 0.000618114133838331 0.00652891256018195 1.75189819270666 0.666666666666667 9.3 9 3 abnormal body wall morphology 0.000618114133838331 0.00652891256018195 1.75189819270666 0.666666666666667 9.3 9 3 absent ureter 0.000618114133838331 0.00652891256018195 1.75189819270666 0.666666666666667 9.3 9 3 long tibia 0.000618114133838331 0.00652891256018195 1.75189819270666 0.666666666666667 9.3 9 3 primary atelectasis 0.000618114133838331 0.00652891256018195 1.75189819270666 0.666666666666667 9.3 9 3 increased effector memory CD8-positive, alpha-beta T cell number 0.000618114133838331 0.00652891256018195 1.75189819270666 0.666666666666667 9.3 9 3 heart hyperplasia 0.0165012889616065 0.0835986889857357 1.75189819270666 0.666666666666667 9.3 9 3 abnormal kindling response 0.0165012889616065 0.0835986889857357 1.75189819270666 0.666666666666667 9.3 9 3 abnormal posterior semicircular canal morphology 0.0165012889616065 0.0835986889857357 1.75189819270666 0.666666666666667 9.3 9 3 pancreas cysts 0.0165012889616065 0.0835986889857357 1.75189819270666 0.666666666666667 9.3 9 3 premature neuronal precursor differentiation 0.0165012889616065 0.0835986889857357 1.75189819270666 0.666666666666667 9.3 9 3 abnormal thymus physiology 0.0165012889616065 0.0835986889857357 1.75189819270666 0.666666666666667 9.3 9 3 decreased cellular sensitivity to ionizing radiation 0.0165012889616065 0.0835986889857357 1.75189819270666 0.666666666666667 9.3 9 3 abnormal proprioceptive neuron morphology 0.0165012889616065 0.0835986889857357 1.75189819270666 0.666666666666667 9.3 9 3 small scapula 0.0165012889616065 0.0835986889857357 1.75189819270666 0.666666666666667 9.3 9 3 abnormal stria vascularis vasculature morphology 0.0165012889616065 0.0835986889857357 1.75189819270666 0.666666666666667 9.3 9 3 liver hyperplasia 0.0165012889616065 0.0835986889857357 1.75189819270666 0.666666666666667 9.3 9 3 abnormal posterior eye segment morphology 0.0165012889616065 0.0835986889857357 1.75189819270666 0.666666666666667 9.3 9 3 abnormal inguinal fat pad morphology 0.0165012889616065 0.0835986889857357 1.75189819270666 0.666666666666667 9.3 9 3 positive geotaxis 0.0165012889616065 0.0835986889857357 1.75189819270666 0.666666666666667 9.3 9 3 abnormal liver vasculature morphology 0.0165012889616065 0.0835986889857357 1.75189819270666 0.666666666666667 9.3 9 3 abnormal incisor color 0.0165012889616065 0.0835986889857357 1.75189819270666 0.666666666666667 9.3 9 3 fusion of atlas and occipital bones 0.0165012889616065 0.0835986889857357 1.75189819270666 0.666666666666667 9.3 9 3 decreased effector memory CD4-positive, alpha-beta T cell number 0.0165012889616065 0.0835986889857357 1.75189819270666 0.666666666666667 9.3 9 3 abnormal lung lobe morphology 0.0165012889616065 0.0835986889857357 1.75189819270666 0.666666666666667 9.3 9 3 increased cardiac muscle glycogen level 0.0165012889616065 0.0835986889857357 1.75189819270666 0.666666666666667 9.3 9 3 abnormal vertebral body morphology 7.9751480855166e-06 0.000161286023274167 1.72452478344562 0.65625 9.3 9 3 scoliosis 7.9751480855166e-06 0.000161286023274167 1.72452478344562 0.65625 9.3 9 3 fragile skeleton 0.00018237590196797 0.00244412514720922 1.71381344938695 0.652173913043478 9.3 9 3 abnormal nasal cavity morphology 0.00018237590196797 0.00244412514720922 1.71381344938695 0.652173913043478 9.3 9 3 abnormal sacral vertebrae morphology 0.00018237590196797 0.00244412514720922 1.71381344938695 0.652173913043478 9.3 9 3 delayed endochondral bone ossification 3.12108878586847e-07 9.70463544355977e-06 1.71115637427162 0.651162790697674 9.3 9 3 abnormal cell proliferation 0.000524073657147348 0.00578107859048349 1.708100737889 0.65 9.3 9 3 spleen atrophy 0.000524073657147348 0.00578107859048349 1.708100737889 0.65 9.3 9 3 absent ductus venosus valve 0.000524073657147348 0.00578107859048349 1.708100737889 0.65 9.3 9 3 abnormal cranial suture morphology 0.00151995874541339 0.0135273609274269 1.70037177527411 0.647058823529412 9.3 9 3 abnormal tendon morphology 0.00151995874541339 0.0135273609274269 1.70037177527411 0.647058823529412 9.3 9 3 abnormal cell cytoskeleton morphology 0.00151995874541339 0.0135273609274269 1.70037177527411 0.647058823529412 9.3 9 3 lymphoid hyperplasia 5.42176064638e-05 0.000859020994131864 1.68933040011 0.642857142857143 9.3 9 3 failure of blastocyst to hatch from the zona pellucida 5.42176064638e-05 0.000859020994131864 1.68933040011 0.642857142857143 9.3 9 3 abnormal voluntary movement 0.00446391205614846 0.0309734483672784 1.68933040011 0.642857142857143 9.3 9 3 abnormal sagittal suture morphology 0.00446391205614846 0.0309734483672784 1.68933040011 0.642857142857143 9.3 9 3 split sternum 0.00446391205614846 0.0309734483672784 1.68933040011 0.642857142857143 9.3 9 3 increased stomach tumor incidence 0.00446391205614846 0.0309734483672784 1.68933040011 0.642857142857143 9.3 9 3 atrioventricular septal defect 2.9730880327022e-08 1.22240602997467e-06 1.68578882694415 0.641509433962264 9.3 9 3 abnormal neurocranium morphology 4.96840958462469e-11 3.63497612992762e-09 1.6818222649984 0.64 9.3 9 3 abnormal neural tube closure 5.64370845188331e-12 5.07914018002525e-10 1.67802296771301 0.63855421686747 9.3 9 3 abnormal extraembryonic tissue morphology 2.68267069537961e-14 3.70730186375376e-12 1.67460856655784 0.637254901960784 9.3 9 3 intracerebral hemorrhage 0.000438050023987194 0.00493142099032697 1.67226645667454 0.636363636363636 9.3 9 3 abnormal occipital bone morphology 0.000438050023987194 0.00493142099032697 1.67226645667454 0.636363636363636 9.3 9 3 increased bone volume 0.000438050023987194 0.00493142099032697 1.67226645667454 0.636363636363636 9.3 9 3 decreased atrioventricular cushion size 0.0133470230856331 0.0707904476023716 1.67226645667454 0.636363636363636 9.3 9 3 delayed hepatic development 0.0133470230856331 0.0707904476023716 1.67226645667454 0.636363636363636 9.3 9 3 abnormal sebaceous gland morphology 0.0133470230856331 0.0707904476023716 1.67226645667454 0.636363636363636 9.3 9 3 abnormal glossopharyngeal ganglion morphology 0.0133470230856331 0.0707904476023716 1.67226645667454 0.636363636363636 9.3 9 3 abnormal bronchiole morphology 0.0133470230856331 0.0707904476023716 1.67226645667454 0.636363636363636 9.3 9 3 retinal detachment 0.0133470230856331 0.0707904476023716 1.67226645667454 0.636363636363636 9.3 9 3 fused joints 0.0133470230856331 0.0707904476023716 1.67226645667454 0.636363636363636 9.3 9 3 impaired luteinization 0.0133470230856331 0.0707904476023716 1.67226645667454 0.636363636363636 9.3 9 3 abnormal coronal suture morphology 0.0133470230856331 0.0707904476023716 1.67226645667454 0.636363636363636 9.3 9 3 abnormal spinal cord ventral horn morphology 0.0133470230856331 0.0707904476023716 1.67226645667454 0.636363636363636 9.3 9 3 abnormal aorta smooth muscle morphology 0.0133470230856331 0.0707904476023716 1.67226645667454 0.636363636363636 9.3 9 3 abnormal phrenic nerve innervation pattern to diaphragm 0.0133470230856331 0.0707904476023716 1.67226645667454 0.636363636363636 9.3 9 3 hypolactation 0.0133470230856331 0.0707904476023716 1.67226645667454 0.636363636363636 9.3 9 3 eyelids open at birth 6.98373417038144e-08 2.57363537019612e-06 1.6676723180573 0.634615384615385 9.3 9 3 palatal shelves fail to meet at midline 1.75494435688492e-06 4.52375553134844e-05 1.66643974428195 0.634146341463415 9.3 9 3 abnormal lactation 4.55318962611501e-05 0.000733078265046025 1.66430328307133 0.633333333333333 9.3 9 3 decreased mean corpuscular hemoglobin 8.74728378155419e-10 5.06020195502699e-08 1.6617269621997 0.632352941176471 9.3 9 3 unresponsive to tactile stimuli 0.00125693118306687 0.011516082202132 1.65969302466947 0.631578947368421 9.3 9 3 abnormal nasal septum morphology 0.00125693118306687 0.011516082202132 1.65969302466947 0.631578947368421 9.3 9 3 abnormal cell adhesion 5.89693680846532e-08 2.22251974409962e-06 1.65457051533407 0.62962962962963 9.3 9 3 decreased circulating fructosamine level 0.00012820008680145 0.00179988993660247 1.65457051533407 0.62962962962963 9.3 9 3 abnormal cell cycle 4.34917560843104e-15 6.76160895373263e-13 1.64526091141147 0.626086956521739 9.3 9 3 delayed hair appearance 0.00363818073758849 0.0261182527698452 1.6424045556625 0.625 9.3 9 3 increased intestinal adenocarcinoma incidence 0.00363818073758849 0.0261182527698452 1.6424045556625 0.625 9.3 9 3 increased pancreatic beta cell number 0.00363818073758849 0.0261182527698452 1.6424045556625 0.625 9.3 9 3 bowed radius 0.00363818073758849 0.0261182527698452 1.6424045556625 0.625 9.3 9 3 blepharitis 0.00363818073758849 0.0261182527698452 1.6424045556625 0.625 9.3 9 3 loose skin 0.00363818073758849 0.0261182527698452 1.6424045556625 0.625 9.3 9 3 impaired somite development 0.00363818073758849 0.0261182527698452 1.6424045556625 0.625 9.3 9 3 abnormal thoracic cage shape 0.00363818073758849 0.0261182527698452 1.6424045556625 0.625 9.3 9 3 embryonic lethality between somite formation and embryo turning, incomplete penetrance 0.00363818073758849 0.0261182527698452 1.6424045556625 0.625 9.3 9 3 decreased adipocyte glucose uptake 0.00363818073758849 0.0261182527698452 1.6424045556625 0.625 9.3 9 3 abnormal exoccipital bone morphology 0.0410279198829294 0.155931169914113 1.6424045556625 0.625 9.3 9 3 schistocytosis 0.0410279198829294 0.155931169914113 1.6424045556625 0.625 9.3 9 3 pointed snout 0.0410279198829294 0.155931169914113 1.6424045556625 0.625 9.3 9 3 abnormal cecum morphology 0.0410279198829294 0.155931169914113 1.6424045556625 0.625 9.3 9 3 enlarged pituitary gland 0.0410279198829294 0.155931169914113 1.6424045556625 0.625 9.3 9 3 abnormal urination 0.0410279198829294 0.155931169914113 1.6424045556625 0.625 9.3 9 3 coarse hair 0.0410279198829294 0.155931169914113 1.6424045556625 0.625 9.3 9 3 altered response to CNS ischemic injury 0.0410279198829294 0.155931169914113 1.6424045556625 0.625 9.3 9 3 hypospadia 0.0410279198829294 0.155931169914113 1.6424045556625 0.625 9.3 9 3 absent tympanic ring 0.0410279198829294 0.155931169914113 1.6424045556625 0.625 9.3 9 3 abnormal cellular cholesterol metabolism 0.0410279198829294 0.155931169914113 1.6424045556625 0.625 9.3 9 3 abnormal umbilical artery morphology 0.0410279198829294 0.155931169914113 1.6424045556625 0.625 9.3 9 3 liver failure 0.0410279198829294 0.155931169914113 1.6424045556625 0.625 9.3 9 3 hair follicle degeneration 0.0410279198829294 0.155931169914113 1.6424045556625 0.625 9.3 9 3 abnormal eyelid aperture 0.0410279198829294 0.155931169914113 1.6424045556625 0.625 9.3 9 3 elevated level of mitotic sister chromatid exchange 0.0410279198829294 0.155931169914113 1.6424045556625 0.625 9.3 9 3 binucleate 0.0410279198829294 0.155931169914113 1.6424045556625 0.625 9.3 9 3 abnormal kidney epithelium morphology 0.0410279198829294 0.155931169914113 1.6424045556625 0.625 9.3 9 3 abnormal vertebral body development 0.0410279198829294 0.155931169914113 1.6424045556625 0.625 9.3 9 3 Sertoli cell hypoplasia 0.0410279198829294 0.155931169914113 1.6424045556625 0.625 9.3 9 3 abnormal ilium morphology 0.0410279198829294 0.155931169914113 1.6424045556625 0.625 9.3 9 3 craniofacial phenotype 0.0410279198829294 0.155931169914113 1.6424045556625 0.625 9.3 9 3 stomach epithelial hyperplasia 0.0410279198829294 0.155931169914113 1.6424045556625 0.625 9.3 9 3 impaired behavioral response to alcohol 0.0410279198829294 0.155931169914113 1.6424045556625 0.625 9.3 9 3 abnormal frontonasal prominence morphology 0.0410279198829294 0.155931169914113 1.6424045556625 0.625 9.3 9 3 abnormal sensory neuron physiology 0.0410279198829294 0.155931169914113 1.6424045556625 0.625 9.3 9 3 decreased quadriceps weight 0.0410279198829294 0.155931169914113 1.6424045556625 0.625 9.3 9 3 myocardial trabeculae hypoplasia 0.0410279198829294 0.155931169914113 1.6424045556625 0.625 9.3 9 3 delayed suture closure 0.0410279198829294 0.155931169914113 1.6424045556625 0.625 9.3 9 3 abnormal heart right ventricle pressure 0.0410279198829294 0.155931169914113 1.6424045556625 0.625 9.3 9 3 abnormal anterior commissure pars posterior morphology 0.0410279198829294 0.155931169914113 1.6424045556625 0.625 9.3 9 3 decreased lung compliance 0.0410279198829294 0.155931169914113 1.6424045556625 0.625 9.3 9 3 abnormal branching involved in ureteric bud morphogenesis 0.0410279198829294 0.155931169914113 1.6424045556625 0.625 9.3 9 3 decreased surfactant secretion 0.0410279198829294 0.155931169914113 1.6424045556625 0.625 9.3 9 3 impaired neuron differentiation 0.0410279198829294 0.155931169914113 1.6424045556625 0.625 9.3 9 3 increased testis apoptosis 0.0410279198829294 0.155931169914113 1.6424045556625 0.625 9.3 9 3 retropleural edema 0.0410279198829294 0.155931169914113 1.6424045556625 0.625 9.3 9 3 decreased body height 0.000362332158183783 0.00431244614106297 1.6424045556625 0.625 9.3 9 3 microcephaly 1.7013152899664e-09 9.20004735606831e-08 1.63764396274753 0.623188405797101 9.3 9 3 enlarged kidney 1.36013002975522e-07 4.63468965618645e-06 1.63620680262226 0.622641509433962 9.3 9 3 malocclusion 1.13153522181108e-05 0.000214862127042372 1.63352669319946 0.621621621621622 9.3 9 3 abnormal axon morphology 7.3268198199183e-14 8.89047039124232e-12 1.63023859599092 0.62037037037037 9.3 9 3 abnormal somite development 1.61005900895964e-10 1.05395310125977e-08 1.62993059701189 0.620253164556962 9.3 9 3 abnormal embryonic tissue morphology 3.27810148226004e-18 7.76597851154461e-16 1.62676260751333 0.619047619047619 9.3 9 3 short maxilla 3.13954395534566e-05 0.000533079562383777 1.62308214912529 0.617647058823529 9.3 9 3 enlarged liver sinusoidal spaces 3.13954395534566e-05 0.000533079562383777 1.62308214912529 0.617647058823529 9.3 9 3 abnormal vitelline vasculature morphology 1.90123032509366e-14 2.70246310495455e-12 1.62241006541965 0.617391304347826 9.3 9 3 increased respiratory quotient 1.02470266257912e-06 2.8479864504643e-05 1.62143768899446 0.617021276595745 9.3 9 3 short premaxilla 0.0106539393520934 0.0594874840366606 1.61713679326769 0.615384615384615 9.3 9 3 absent myocardial trabeculae 0.0106539393520934 0.0594874840366606 1.61713679326769 0.615384615384615 9.3 9 3 increased pituitary adenoma incidence 0.0106539393520934 0.0594874840366606 1.61713679326769 0.615384615384615 9.3 9 3 abnormal lung interstitium morphology 0.0106539393520934 0.0594874840366606 1.61713679326769 0.615384615384615 9.3 9 3 anal atresia 0.0106539393520934 0.0594874840366606 1.61713679326769 0.615384615384615 9.3 9 3 axonal dystrophy 0.0106539393520934 0.0594874840366606 1.61713679326769 0.615384615384615 9.3 9 3 decreased neuronal precursor cell number 8.72097753198329e-05 0.00128363500655671 1.61061608039161 0.612903225806452 9.3 9 3 rib fusion 8.77659985815976e-09 3.96941675403135e-07 1.6080856544994 0.611940298507463 9.3 9 3 abnormal lung development 9.34918947699098e-11 6.33242144832457e-09 1.60762422389553 0.611764705882353 9.3 9 3 lowered ear position 0.00293714313503134 0.022072941233808 1.60590667664777 0.611111111111111 9.3 9 3 abnormal mitral valve morphology 0.00293714313503134 0.022072941233808 1.60590667664777 0.611111111111111 9.3 9 3 underdeveloped hair follicles 0.00293714313503134 0.022072941233808 1.60590667664777 0.611111111111111 9.3 9 3 absent inner cell mass 0.00293714313503134 0.022072941233808 1.60590667664777 0.611111111111111 9.3 9 3 abnormal eye anterior chamber morphology 0.00293714313503134 0.022072941233808 1.60590667664777 0.611111111111111 9.3 9 3 increased gastrointestinal tumor incidence 0.00293714313503134 0.022072941233808 1.60590667664777 0.611111111111111 9.3 9 3 abnormal aerobic respiration 0.00293714313503134 0.022072941233808 1.60590667664777 0.611111111111111 9.3 9 3 perimembraneous ventricular septal defect 7.27149546515106e-09 3.38090560178752e-07 1.59955921942782 0.608695652173913 9.3 9 3 failure to gastrulate 2.31960407192703e-06 5.82829811001867e-05 1.59955921942782 0.608695652173913 9.3 9 3 abnormal cardiovascular development 0.000835765324905988 0.00820105027890984 1.59955921942782 0.608695652173913 9.3 9 3 abnormal chondrocyte physiology 0.000835765324905988 0.00820105027890984 1.59955921942782 0.608695652173913 9.3 9 3 shortened head 0.000242536647323271 0.00307027944130604 1.595478711215 0.607142857142857 9.3 9 3 small superior cervical ganglion 0.000242536647323271 0.00307027944130604 1.595478711215 0.607142857142857 9.3 9 3 abnormal renal tubule epithelium morphology 0.000242536647323271 0.00307027944130604 1.595478711215 0.607142857142857 9.3 9 3 abnormal mitotic spindle morphology 0.000242536647323271 0.00307027944130604 1.595478711215 0.607142857142857 9.3 9 3 subcutaneous edema 0.000242536647323271 0.00307027944130604 1.595478711215 0.607142857142857 9.3 9 3 lethality throughout fetal growth and development, complete penetrance 1.81014177969597e-21 5.00303075221526e-19 1.59053914864157 0.605263157894737 9.3 9 3 decreased hair follicle number 2.11826436563796e-05 0.000373700894292513 1.59053914864157 0.605263157894737 9.3 9 3 abnormal vasculogenesis 6.33645073515042e-06 0.000134144010244142 1.58893091896651 0.604651162790698 9.3 9 3 hemorrhage 4.66442967599227e-26 1.9337948031718e-23 1.58789070232561 0.604255319148936 9.3 9 3 vertebral transformation 1.90622170973496e-06 4.86330923381099e-05 1.58765773714041 0.604166666666667 9.3 9 3 abnormal osteoclast morphology 1.90622170973496e-06 4.86330923381099e-05 1.58765773714041 0.604166666666667 9.3 9 3 ventricular septal defect 1.34302647073824e-15 2.30398506618026e-13 1.58443733605088 0.602941176470588 9.3 9 3 abnormal liver development 5.80990091816036e-05 0.000903258033370244 1.576708373436 0.6 9.3 9 3 abnormal dermal layer morphology 5.80990091816036e-05 0.000903258033370244 1.576708373436 0.6 9.3 9 3 abnormal embryonic epiblast morphology 5.80990091816036e-05 0.000903258033370244 1.576708373436 0.6 9.3 9 3 delayed bone ossification 4.07616855803014e-09 1.95050958027519e-07 1.576708373436 0.6 9.3 9 3 abnormal myocardial trabeculae morphology 5.18346814986728e-06 0.000113104184410481 1.576708373436 0.6 9.3 9 3 emphysema 0.000196890519727882 0.00261208089505656 1.576708373436 0.6 9.3 9 3 disorganized myocardium 0.000196890519727882 0.00261208089505656 1.576708373436 0.6 9.3 9 3 spontaneous skin ulceration 0.000675284050409286 0.00711766557369957 1.576708373436 0.6 9.3 9 3 abnormal basioccipital bone morphology 0.00235621747194614 0.0185852423682732 1.576708373436 0.6 9.3 9 3 abnormal incus morphology 0.00235621747194614 0.0185852423682732 1.576708373436 0.6 9.3 9 3 decreased chondrocyte number 0.00844340655317091 0.0486179949097515 1.576708373436 0.6 9.3 9 3 placental labyrinth hypoplasia 0.00844340655317091 0.0486179949097515 1.576708373436 0.6 9.3 9 3 abnormal pericyte morphology 0.00844340655317091 0.0486179949097515 1.576708373436 0.6 9.3 9 3 abnormal ear development 0.00844340655317091 0.0486179949097515 1.576708373436 0.6 9.3 9 3 abnormal olfactory nerve morphology 0.00844340655317091 0.0486179949097515 1.576708373436 0.6 9.3 9 3 abnormal energy homeostasis 0.00844340655317091 0.0486179949097515 1.576708373436 0.6 9.3 9 3 decreased thymocyte apoptosis 0.00844340655317091 0.0486179949097515 1.576708373436 0.6 9.3 9 3 absent chorion 0.00844340655317091 0.0486179949097515 1.576708373436 0.6 9.3 9 3 abnormal lateral semicircular canal morphology 0.0317086679481623 0.128461419415397 1.576708373436 0.6 9.3 9 3 absent maxillary shelf 0.0317086679481623 0.128461419415397 1.576708373436 0.6 9.3 9 3 enlarged testis 0.0317086679481623 0.128461419415397 1.576708373436 0.6 9.3 9 3 abnormal mammary gland physiology 0.0317086679481623 0.128461419415397 1.576708373436 0.6 9.3 9 3 abnormal respiratory mechanics 0.0317086679481623 0.128461419415397 1.576708373436 0.6 9.3 9 3 abnormal neuron specification 0.0317086679481623 0.128461419415397 1.576708373436 0.6 9.3 9 3 delayed dark adaptation 0.0317086679481623 0.128461419415397 1.576708373436 0.6 9.3 9 3 acrania 0.0317086679481623 0.128461419415397 1.576708373436 0.6 9.3 9 3 bifid ureter 0.0317086679481623 0.128461419415397 1.576708373436 0.6 9.3 9 3 abnormal pillar cell morphology 0.0317086679481623 0.128461419415397 1.576708373436 0.6 9.3 9 3 abnormal reproductive system development 0.0317086679481623 0.128461419415397 1.576708373436 0.6 9.3 9 3 abnormal placental transport 0.0317086679481623 0.128461419415397 1.576708373436 0.6 9.3 9 3 abnormal corneal endothelium morphology 0.0317086679481623 0.128461419415397 1.576708373436 0.6 9.3 9 3 increased platelet aggregation 0.0317086679481623 0.128461419415397 1.576708373436 0.6 9.3 9 3 abnormal spinal cord dorsal column morphology 0.0317086679481623 0.128461419415397 1.576708373436 0.6 9.3 9 3 increased kidney iron level 0.0317086679481623 0.128461419415397 1.576708373436 0.6 9.3 9 3 abnormal heart and great artery attachment 0.0317086679481623 0.128461419415397 1.576708373436 0.6 9.3 9 3 fusion of atlas and odontoid process 0.0317086679481623 0.128461419415397 1.576708373436 0.6 9.3 9 3 double outlet right ventricle 2.82333469698708e-12 2.65020568254919e-10 1.5717965093443 0.598130841121495 9.3 9 3 lethality throughout fetal growth and development, incomplete penetrance 1.68067918182805e-19 4.18068946479728e-17 1.57083608899117 0.597765363128492 9.3 9 3 prenatal lethality 1.17499960392904e-07 4.08784827241049e-06 1.56823144669709 0.596774193548387 9.3 9 3 abnormal cartilage morphology 1.40770464994057e-05 0.000255596008520232 1.56419481491666 0.595238095238095 9.3 9 3 abnormal placenta morphology 2.74330127246855e-09 1.38827620119461e-07 1.56340281754202 0.594936708860759 9.3 9 3 decreased width of hypertrophic chondrocyte zone 4.71576616798551e-05 0.000756804409217029 1.56250379349513 0.594594594594595 9.3 9 3 decreased tumor growth/size 1.04000637615664e-06 2.87446206743294e-05 1.55724283796148 0.592592592592593 9.3 9 3 thin epidermis 0.00054337591883232 0.00595439470526607 1.55724283796148 0.592592592592593 9.3 9 3 increased brain weight 0.00054337591883232 0.00595439470526607 1.55724283796148 0.592592592592593 9.3 9 3 abnormal skeleton morphology 1.27976442295131e-12 1.24839764787898e-10 1.55385752744417 0.591304347826087 9.3 9 3 small kidney 5.63381815729461e-10 3.38249165454219e-08 1.55281885262636 0.590909090909091 9.3 9 3 abnormal germ layer development 0.00188197207707661 0.0157710255666151 1.55281885262636 0.590909090909091 9.3 9 3 abnormal tracheal cartilage morphology 0.00188197207707661 0.0157710255666151 1.55281885262636 0.590909090909091 9.3 9 3 abnormal vascular branching morphogenesis 0.00188197207707661 0.0157710255666151 1.55281885262636 0.590909090909091 9.3 9 3 prolonged PR interval 0.00188197207707661 0.0157710255666151 1.55281885262636 0.590909090909091 9.3 9 3 abnormal basement membrane morphology 0.00188197207707661 0.0157710255666151 1.55281885262636 0.590909090909091 9.3 9 3 rough coat 0.00188197207707661 0.0157710255666151 1.55281885262636 0.590909090909091 9.3 9 3 increased mammary gland tumor incidence 0.00188197207707661 0.0157710255666151 1.55281885262636 0.590909090909091 9.3 9 3 embryonic lethality before implantation, incomplete penetrance 0.00188197207707661 0.0157710255666151 1.55281885262636 0.590909090909091 9.3 9 3 pale yolk sac 1.83396702633717e-09 9.70636803832706e-08 1.55137972486674 0.590361445783133 9.3 9 3 abnormal long bone morphology 2.57094973384417e-07 8.25191930701596e-06 1.55086069518295 0.590163934426229 9.3 9 3 overexpanded pulmonary alveoli 0.000128382254974944 0.00179988993660247 1.54579252297647 0.588235294117647 9.3 9 3 abnormal interatrial septum morphology 0.00666421215498151 0.0414949380113054 1.54579252297647 0.588235294117647 9.3 9 3 hyperlipidemia 0.00666421215498151 0.0414949380113054 1.54579252297647 0.588235294117647 9.3 9 3 abnormal embryonic-extraembryonic boundary morphology 0.00666421215498151 0.0414949380113054 1.54579252297647 0.588235294117647 9.3 9 3 pancytopenia 0.00666421215498151 0.0414949380113054 1.54579252297647 0.588235294117647 9.3 9 3 enhanced behavioral response to cocaine 0.00666421215498151 0.0414949380113054 1.54579252297647 0.588235294117647 9.3 9 3 distended abdomen 2.79220333153238e-06 6.86218128334909e-05 1.54579252297647 0.588235294117647 9.3 9 3 abnormal trophoblast layer morphology 2.79220333153238e-06 6.86218128334909e-05 1.54579252297647 0.588235294117647 9.3 9 3 abnormal forelimb morphology 9.2531697343087e-06 0.00018340445987325 1.54243210444826 0.58695652173913 9.3 9 3 abnormal myelin sheath morphology 9.2531697343087e-06 0.00018340445987325 1.54243210444826 0.58695652173913 9.3 9 3 embryonic lethality between implantation and placentation, complete penetrance 9.2531697343087e-06 0.00018340445987325 1.54243210444826 0.58695652173913 9.3 9 3 abnormal limb morphology 1.58860502075661e-08 6.93272805110888e-07 1.54167040958186 0.586666666666667 9.3 9 3 abnormal embryonic neuroepithelium morphology 6.86719017690078e-07 1.95224406457608e-05 1.54046220393172 0.586206896551724 9.3 9 3 abnormal embryonic erythropoiesis 0.000435856824696795 0.00493142099032697 1.54046220393172 0.586206896551724 9.3 9 3 short sternum 0.000435856824696795 0.00493142099032697 1.54046220393172 0.586206896551724 9.3 9 3 decreased circulating serum albumin level 9.41907913921645e-11 6.33242144832457e-09 1.53954689662101 0.585858585858586 9.3 9 3 abnormal embryo size 5.9578824841836e-12 5.11042506186438e-10 1.53484885909699 0.584070796460177 9.3 9 3 intracranial hemorrhage 5.56554766332803e-07 1.60980230378238e-05 1.53291091861833 0.583333333333333 9.3 9 3 ocular hypertelorism 0.00149857175831707 0.0134089829094018 1.53291091861833 0.583333333333333 9.3 9 3 abnormal nursing 0.00149857175831707 0.0134089829094018 1.53291091861833 0.583333333333333 9.3 9 3 abnormal tumor morphology 0.00149857175831707 0.0134089829094018 1.53291091861833 0.583333333333333 9.3 9 3 abnormal truncus arteriosus septation 0.00149857175831707 0.0134089829094018 1.53291091861833 0.583333333333333 9.3 9 3 abnormal supraoccipital bone morphology 0.0244783608242212 0.103996451836465 1.53291091861833 0.583333333333333 9.3 9 3 abnormal rectum morphology 0.0244783608242212 0.103996451836465 1.53291091861833 0.583333333333333 9.3 9 3 absent optic nerve 0.0244783608242212 0.103996451836465 1.53291091861833 0.583333333333333 9.3 9 3 interstitial pneumonia 0.0244783608242212 0.103996451836465 1.53291091861833 0.583333333333333 9.3 9 3 altered tumor susceptibility 0.0244783608242212 0.103996451836465 1.53291091861833 0.583333333333333 9.3 9 3 decreased synaptic depression 0.0244783608242212 0.103996451836465 1.53291091861833 0.583333333333333 9.3 9 3 small intestinal inflammation 0.0244783608242212 0.103996451836465 1.53291091861833 0.583333333333333 9.3 9 3 abnormal nucleotide metabolism 0.0244783608242212 0.103996451836465 1.53291091861833 0.583333333333333 9.3 9 3 abnormal defecation 0.0244783608242212 0.103996451836465 1.53291091861833 0.583333333333333 9.3 9 3 increased hepatocyte proliferation 0.0244783608242212 0.103996451836465 1.53291091861833 0.583333333333333 9.3 9 3 bowed ulna 0.0244783608242212 0.103996451836465 1.53291091861833 0.583333333333333 9.3 9 3 small parietal bone 0.0244783608242212 0.103996451836465 1.53291091861833 0.583333333333333 9.3 9 3 hematuria 0.0244783608242212 0.103996451836465 1.53291091861833 0.583333333333333 9.3 9 3 abnormal pulmonary valve cusp morphology 0.0244783608242212 0.103996451836465 1.53291091861833 0.583333333333333 9.3 9 3 increased type II pneumocyte number 0.0244783608242212 0.103996451836465 1.53291091861833 0.583333333333333 9.3 9 3 abnormal respiratory motile cilium morphology 0.0244783608242212 0.103996451836465 1.53291091861833 0.583333333333333 9.3 9 3 hydrops fetalis 4.21219547540158e-08 1.62447073566844e-06 1.53291091861833 0.583333333333333 9.3 9 3 impaired wound healing 0.000103253196533287 0.00148463772471995 1.53291091861833 0.583333333333333 9.3 9 3 decreased embryo size 3.4163862741788e-45 2.83275361900658e-42 1.52832959489263 0.581589958158996 9.3 9 3 abnormal angiogenesis 3.41540305534877e-08 1.35933041602881e-06 1.52699234364297 0.581081081081081 9.3 9 3 inner cell mass degeneration 0.000348756165831333 0.00418087210845995 1.52584681300258 0.580645161290323 9.3 9 3 short stride length 6.03311738143352e-06 0.000128268200737743 1.5241514276548 0.58 9.3 9 3 perinatal lethality, incomplete penetrance 7.5799673319755e-22 2.21825514568106e-19 1.52322121622504 0.579646017699115 9.3 9 3 embryonic lethality between implantation and somite formation, complete penetrance 1.49765185465342e-23 5.3220128406434e-21 1.52307883692457 0.579591836734694 9.3 9 3 abnormal cell morphology 1.03418183544872e-11 8.43451578911048e-10 1.52138527261368 0.578947368421053 9.3 9 3 decreased birth body size 1.03418183544872e-11 8.43451578911048e-10 1.52138527261368 0.578947368421053 9.3 9 3 short vibrissae 0.0052474345689825 0.0355667397557056 1.52138527261368 0.578947368421053 9.3 9 3 maternal imprinting 0.0052474345689825 0.0355667397557056 1.52138527261368 0.578947368421053 9.3 9 3 increased circulating VLDL cholesterol level 0.0052474345689825 0.0355667397557056 1.52138527261368 0.578947368421053 9.3 9 3 decreased liver regeneration 0.0052474345689825 0.0355667397557056 1.52138527261368 0.578947368421053 9.3 9 3 increased liver cholesterol level 0.0052474345689825 0.0355667397557056 1.52138527261368 0.578947368421053 9.3 9 3 pallor 5.23109770012866e-17 1.08436296075584e-14 1.5166432925432 0.577142857142857 9.3 9 3 kinked neural tube 4.85982200265433e-06 0.000106980594969935 1.51606574368846 0.576923076923077 9.3 9 3 decreased kidney weight 4.85982200265433e-06 0.000106980594969935 1.51606574368846 0.576923076923077 9.3 9 3 abnormal brain wave pattern 4.85982200265433e-06 0.000106980594969935 1.51606574368846 0.576923076923077 9.3 9 3 abnormal kidney cortex morphology 0.00119065439713009 0.0110307367331885 1.51606574368846 0.576923076923077 9.3 9 3 thick skin 0.00119065439713009 0.0110307367331885 1.51606574368846 0.576923076923077 9.3 9 3 increased leukemia incidence 0.00119065439713009 0.0110307367331885 1.51606574368846 0.576923076923077 9.3 9 3 increased thymocyte apoptosis 0.00119065439713009 0.0110307367331885 1.51606574368846 0.576923076923077 9.3 9 3 abnormal vascular development 2.93768508982216e-07 9.2499894442185e-06 1.5130029846103 0.575757575757576 9.3 9 3 abnormal skeleton physiology 0.000278523401185095 0.00348154251481369 1.5130029846103 0.575757575757576 9.3 9 3 cleft secondary palate 1.12598011470937e-09 6.3656262166808e-08 1.50961440009829 0.574468085106383 9.3 9 3 pulmonary hypoplasia 1.60373111009792e-05 0.000289078343215114 1.50961440009829 0.574468085106383 9.3 9 3 abnormal chondrocyte morphology 3.90943527925743e-06 9.00437060847487e-05 1.50857899927518 0.574074074074074 9.3 9 3 embryonic lethality during organogenesis, complete penetrance 4.07745352396075e-50 6.76177709390158e-47 1.50631960676475 0.573214285714286 9.3 9 3 abnormal craniofacial morphology 2.27834182260349e-10 1.42107644882102e-08 1.50527174810233 0.572815533980582 9.3 9 3 abnormal erythropoiesis 1.8403452195193e-10 1.1890542165076e-08 1.50162702232 0.571428571428571 9.3 9 3 domed cranium 1.90761193562563e-07 6.28501283426324e-06 1.50162702232 0.571428571428571 9.3 9 3 abnormal craniofacial development 1.28628909591751e-05 0.000240574746322917 1.50162702232 0.571428571428571 9.3 9 3 abnormal midbrain development 0.000222093249366065 0.00286990627427577 1.50162702232 0.571428571428571 9.3 9 3 decreased glycogen level 0.000222093249366065 0.00286990627427577 1.50162702232 0.571428571428571 9.3 9 3 decreased bone volume 0.000222093249366065 0.00286990627427577 1.50162702232 0.571428571428571 9.3 9 3 abnormal circulating cholesterol level 0.000944494947511053 0.00896729458753338 1.50162702232 0.571428571428571 9.3 9 3 translucent skin 0.01890730908002 0.0930404180742822 1.50162702232 0.571428571428571 9.3 9 3 abnormal placing response 0.01890730908002 0.0930404180742822 1.50162702232 0.571428571428571 9.3 9 3 extended life span 0.01890730908002 0.0930404180742822 1.50162702232 0.571428571428571 9.3 9 3 absent visceral yolk sac blood islands 0.01890730908002 0.0930404180742822 1.50162702232 0.571428571428571 9.3 9 3 increased lactate dehydrogenase level 0.01890730908002 0.0930404180742822 1.50162702232 0.571428571428571 9.3 9 3 intestinal obstruction 0.01890730908002 0.0930404180742822 1.50162702232 0.571428571428571 9.3 9 3 amyloid beta deposits 0.01890730908002 0.0930404180742822 1.50162702232 0.571428571428571 9.3 9 3 failure of zygotic cell division 0.01890730908002 0.0930404180742822 1.50162702232 0.571428571428571 9.3 9 3 abnormal vascular endothelial cell migration 0.01890730908002 0.0930404180742822 1.50162702232 0.571428571428571 9.3 9 3 vascular smooth muscle hypoplasia 0.01890730908002 0.0930404180742822 1.50162702232 0.571428571428571 9.3 9 3 abnormal pancreas development 0.01890730908002 0.0930404180742822 1.50162702232 0.571428571428571 9.3 9 3 increased circulating growth hormone level 0.01890730908002 0.0930404180742822 1.50162702232 0.571428571428571 9.3 9 3 abnormal viscerocranium morphology 0.01890730908002 0.0930404180742822 1.50162702232 0.571428571428571 9.3 9 3 sternebra fusion 0.01890730908002 0.0930404180742822 1.50162702232 0.571428571428571 9.3 9 3 abnormal vitelline vein topology 0.01890730908002 0.0930404180742822 1.50162702232 0.571428571428571 9.3 9 3 decreased response to antigen 0.01890730908002 0.0930404180742822 1.50162702232 0.571428571428571 9.3 9 3 skin edema 5.31313550308641e-05 0.000847206702815863 1.50162702232 0.571428571428571 9.3 9 3 abnormal reproductive system morphology 5.31313550308641e-05 0.000847206702815863 1.50162702232 0.571428571428571 9.3 9 3 abnormal hematopoietic system physiology 0.00412618022208507 0.0289256793663086 1.50162702232 0.571428571428571 9.3 9 3 abnormal stapes morphology 0.00412618022208507 0.0289256793663086 1.50162702232 0.571428571428571 9.3 9 3 increased keratinocyte proliferation 0.00412618022208507 0.0289256793663086 1.50162702232 0.571428571428571 9.3 9 3 complete atrioventricular septal defect 0.00412618022208507 0.0289256793663086 1.50162702232 0.571428571428571 9.3 9 3 vascular ring 0.00412618022208507 0.0289256793663086 1.50162702232 0.571428571428571 9.3 9 3 absent segment of posterior cerebral artery 0.00412618022208507 0.0289256793663086 1.50162702232 0.571428571428571 9.3 9 3 edema 4.8750707208595e-16 9.32826032164463e-14 1.49726182748767 0.569767441860465 9.3 9 3 increased circulating creatinine level 9.4910563494858e-09 4.2538743548371e-07 1.49726182748767 0.569767441860465 9.3 9 3 embryonic lethality during organogenesis, incomplete penetrance 6.46736902765059e-21 1.69342952171377e-18 1.49673041246461 0.569565217391304 9.3 9 3 failure of chorioallantoic fusion 1.03052313563032e-05 0.000201053043127876 1.49426610554392 0.568627450980392 9.3 9 3 abnormal eye morphology 3.86467275053134e-13 4.17972759432466e-11 1.49352471824273 0.568345323741007 9.3 9 3 omphalocele 4.24614528161464e-05 0.000692608943476486 1.49309505060227 0.568181818181818 9.3 9 3 abnormal neural tube morphology 4.99606286889075e-15 7.53194326446408e-13 1.49235771971308 0.567901234567901 9.3 9 3 abnormal skeleton development 3.06700400537614e-08 1.25068401038904e-06 1.49235771971308 0.567901234567901 9.3 9 3 abnormal kidney development 2.02174959214397e-06 5.13173684740624e-05 1.48911346380066 0.566666666666667 9.3 9 3 abnormal sternum morphology 3.99926697210094e-07 1.22063516479768e-05 1.48530498946869 0.565217391304348 9.3 9 3 dilated heart 0.00324204085489841 0.023840842116627 1.48530498946869 0.565217391304348 9.3 9 3 abnormal ulna morphology 0.00324204085489841 0.023840842116627 1.48530498946869 0.565217391304348 9.3 9 3 abnormal corneal stroma morphology 0.00324204085489841 0.023840842116627 1.48530498946869 0.565217391304348 9.3 9 3 abnormal palatal shelf fusion at midline 0.00324204085489841 0.023840842116627 1.48530498946869 0.565217391304348 9.3 9 3 embryonic lethality, complete penetrance 1.60727581281467e-27 7.2692701534118e-25 1.48279784335674 0.564263322884012 9.3 9 3 abnormal heart looping 0.00014072928884778 0.00193941332968893 1.48237539382871 0.564102564102564 9.3 9 3 abnormal embryo turning 6.59590667319607e-06 0.000137876620584666 1.48115029019745 0.563636363636364 9.3 9 3 decreased circulating total protein level 6.59590667319607e-06 0.000137876620584666 1.48115029019745 0.563636363636364 9.3 9 3 abnormal lung morphology 4.05822752726696e-11 3.05904271941714e-09 1.47954427199176 0.563025210084034 9.3 9 3 abnormal osteoclast physiology 1.29690489291629e-06 3.46887195820352e-05 1.47816410009625 0.5625 9.3 9 3 curly tail 2.70418809662839e-05 0.000465513348814058 1.47816410009625 0.5625 9.3 9 3 kidney cortex cysts 0.000592431489259528 0.00642123455134238 1.47816410009625 0.5625 9.3 9 3 pancreatic islet hyperplasia 0.000592431489259528 0.00642123455134238 1.47816410009625 0.5625 9.3 9 3 abnormal molar crown morphology 0.0146215540303484 0.0767323114989273 1.47816410009625 0.5625 9.3 9 3 dystonia 0.0146215540303484 0.0767323114989273 1.47816410009625 0.5625 9.3 9 3 kidney degeneration 0.0146215540303484 0.0767323114989273 1.47816410009625 0.5625 9.3 9 3 decreased liver cholesterol level 0.0146215540303484 0.0767323114989273 1.47816410009625 0.5625 9.3 9 3 abnormal pulmonary alveolus wall morphology 0.0146215540303484 0.0767323114989273 1.47816410009625 0.5625 9.3 9 3 incomplete embryo turning 5.2707282204851e-06 0.000114505995183028 1.47528268859508 0.56140350877193 9.3 9 3 polydactyly 2.56522699618315e-09 1.32937544854283e-07 1.47481225406428 0.561224489795918 9.3 9 3 hemopericardium 0.000111877896686706 0.00159485632567017 1.47415823532634 0.560975609756098 9.3 9 3 preweaning lethality, complete penetrance 5.86357922330735e-61 2.91713066359541e-57 1.47372516886473 0.560810810810811 9.3 9 3 decreased erythrocyte cell number 5.50983880662884e-14 6.85286201574462e-12 1.47293351233936 0.560509554140127 9.3 9 3 abnormal interventricular septum morphology 2.15553300581187e-05 0.00037759777126458 1.4715944818736 0.56 9.3 9 3 decreased circulating alkaline phosphatase level 2.15553300581187e-05 0.00037759777126458 1.4715944818736 0.56 9.3 9 3 abnormal egg cylinder morphology 0.00254639247747244 0.0195498496534343 1.4715944818736 0.56 9.3 9 3 diaphragmatic hernia 0.00254639247747244 0.0195498496534343 1.4715944818736 0.56 9.3 9 3 abnormal vertebrae development 0.00254639247747244 0.0195498496534343 1.4715944818736 0.56 9.3 9 3 hypoglycemia 8.21794923843582e-09 3.75085297809342e-07 1.46933396807656 0.559139784946237 9.3 9 3 lung hemorrhage 0.000468702186384616 0.00522823627189118 1.46850289682764 0.558823529411765 9.3 9 3 kidney failure 8.88831206069955e-05 0.00130440567852449 1.46670546366139 0.558139534883721 9.3 9 3 abnormal placenta vasculature 1.71711822804691e-05 0.000307290042609114 1.46553021889884 0.557692307692308 9.3 9 3 prenatal lethality, complete penetrance 3.55825250389306e-23 1.18015374712453e-20 1.4651666539723 0.557553956834532 9.3 9 3 cleft palate 1.08985215567141e-11 8.74518463623433e-10 1.46437291680442 0.557251908396947 9.3 9 3 embryonic lethality between somite formation and embryo turning, complete penetrance 6.63070395347311e-07 1.90680648372998e-05 1.464086346762 0.557142857142857 9.3 9 3 prenatal lethality, incomplete penetrance 6.05374821204882e-25 2.31672287345714e-22 1.46087563108927 0.555921052631579 9.3 9 3 abnormal apoptosis 1.36713477470937e-05 0.000252843699040116 1.45991516058889 0.555555555555556 9.3 9 3 abnormal long bone epiphyseal plate proliferative zone 1.36713477470937e-05 0.000252843699040116 1.45991516058889 0.555555555555556 9.3 9 3 axon degeneration 1.36713477470937e-05 0.000252843699040116 1.45991516058889 0.555555555555556 9.3 9 3 rectal prolapse 0.0019997524950023 0.0164987871685513 1.45991516058889 0.555555555555556 9.3 9 3 abnormal eye muscle morphology 0.0019997524950023 0.0164987871685513 1.45991516058889 0.555555555555556 9.3 9 3 abnormal skin appearance 0.0019997524950023 0.0164987871685513 1.45991516058889 0.555555555555556 9.3 9 3 abnormal bone trabecula morphology 0.0019997524950023 0.0164987871685513 1.45991516058889 0.555555555555556 9.3 9 3 abnormal forebrain development 5.29644584689663e-07 1.56844155287564e-05 1.45991516058889 0.555555555555556 9.3 9 3 abnormal uterus morphology 0.000370643315407036 0.00435922102635934 1.45991516058889 0.555555555555556 9.3 9 3 short radius 0.000370643315407036 0.00435922102635934 1.45991516058889 0.555555555555556 9.3 9 3 delayed kidney development 0.0113230484299192 0.0621082314651026 1.45991516058889 0.555555555555556 9.3 9 3 blepharoptosis 0.0113230484299192 0.0621082314651026 1.45991516058889 0.555555555555556 9.3 9 3 abnormal anterior eye segment morphology 0.0113230484299192 0.0621082314651026 1.45991516058889 0.555555555555556 9.3 9 3 abnormal glycogen homeostasis 0.0113230484299192 0.0621082314651026 1.45991516058889 0.555555555555556 9.3 9 3 atrioventricular block 0.0113230484299192 0.0621082314651026 1.45991516058889 0.555555555555556 9.3 9 3 abnormal metanephric mesenchyme morphology 0.0113230484299192 0.0621082314651026 1.45991516058889 0.555555555555556 9.3 9 3 increased adipocyte glucose uptake 0.0113230484299192 0.0621082314651026 1.45991516058889 0.555555555555556 9.3 9 3 abnormal head movements 0.0716862085345831 0.22255416112574 1.45991516058889 0.555555555555556 9.3 9 3 crypts of Lieberkuhn abscesses 0.0716862085345831 0.22255416112574 1.45991516058889 0.555555555555556 9.3 9 3 synostosis 0.0716862085345831 0.22255416112574 1.45991516058889 0.555555555555556 9.3 9 3 abnormal sympathetic neuron morphology 0.0716862085345831 0.22255416112574 1.45991516058889 0.555555555555556 9.3 9 3 abnormal cholinergic neuron morphology 0.0716862085345831 0.22255416112574 1.45991516058889 0.555555555555556 9.3 9 3 abnormal lung volume 0.0716862085345831 0.22255416112574 1.45991516058889 0.555555555555556 9.3 9 3 abnormal laryngeal cartilage morphology 0.0716862085345831 0.22255416112574 1.45991516058889 0.555555555555556 9.3 9 3 genetic imprinting 0.0716862085345831 0.22255416112574 1.45991516058889 0.555555555555556 9.3 9 3 decreased fear-related response 0.0716862085345831 0.22255416112574 1.45991516058889 0.555555555555556 9.3 9 3 short frontal bone 0.0716862085345831 0.22255416112574 1.45991516058889 0.555555555555556 9.3 9 3 abnormal gallbladder physiology 0.0716862085345831 0.22255416112574 1.45991516058889 0.555555555555556 9.3 9 3 absent adrenal gland 0.0716862085345831 0.22255416112574 1.45991516058889 0.555555555555556 9.3 9 3 decreased susceptibility to atherosclerosis 0.0716862085345831 0.22255416112574 1.45991516058889 0.555555555555556 9.3 9 3 eye opacity 0.0716862085345831 0.22255416112574 1.45991516058889 0.555555555555556 9.3 9 3 abnormal hippocampus granule cell morphology 0.0716862085345831 0.22255416112574 1.45991516058889 0.555555555555556 9.3 9 3 abnormal cerebellar layer morphology 0.0716862085345831 0.22255416112574 1.45991516058889 0.555555555555556 9.3 9 3 prolonged RR interval 0.0716862085345831 0.22255416112574 1.45991516058889 0.555555555555556 9.3 9 3 abnormal heart left ventricle pressure 0.0716862085345831 0.22255416112574 1.45991516058889 0.555555555555556 9.3 9 3 abnormal ureteric bud invasion 0.0716862085345831 0.22255416112574 1.45991516058889 0.555555555555556 9.3 9 3 decreased bone trabecular spacing 0.0716862085345831 0.22255416112574 1.45991516058889 0.555555555555556 9.3 9 3 abnormal ductus venosus valve topology 0.0716862085345831 0.22255416112574 1.45991516058889 0.555555555555556 9.3 9 3 abnormal coronary sinus connection 0.0716862085345831 0.22255416112574 1.45991516058889 0.555555555555556 9.3 9 3 symmetric azygos veins 0.0716862085345831 0.22255416112574 1.45991516058889 0.555555555555556 9.3 9 3 decreased fatty acid oxidation 0.0716862085345831 0.22255416112574 1.45991516058889 0.555555555555556 9.3 9 3 decreased platelet dense granule number 0.0716862085345831 0.22255416112574 1.45991516058889 0.555555555555556 9.3 9 3 short tail 8.42043479372343e-08 3.05778562764774e-06 1.45639729273204 0.55421686746988 9.3 9 3 abnormal cell nucleus morphology 5.6016057838451e-05 0.00088469805633744 1.45370275565021 0.553191489361702 9.3 9 3 decreased neuron apoptosis 0.000293002748727944 0.00358154465582683 1.45223139658579 0.552631578947368 9.3 9 3 impaired branching involved in ureteric bud morphogenesis 0.000293002748727944 0.00358154465582683 1.45223139658579 0.552631578947368 9.3 9 3 increased insulin sensitivity 2.88976385370729e-12 2.66232873559144e-10 1.45174780304713 0.552447552447552 9.3 9 3 abnormal parietal bone morphology 0.00157051109866707 0.0138779621951486 1.44984678017103 0.551724137931034 9.3 9 3 lordosis 0.00157051109866707 0.0138779621951486 1.44984678017103 0.551724137931034 9.3 9 3 blood in lymph vessels 0.00157051109866707 0.0138779621951486 1.44984678017103 0.551724137931034 9.3 9 3 decreased cell proliferation 2.52174965468493e-15 4.04700146195404e-13 1.44886715396821 0.551351351351351 9.3 9 3 small liver 2.69254547675263e-07 8.53211066677984e-06 1.44868504396897 0.551282051282051 9.3 9 3 increased embryonic tissue cell apoptosis 2.69254547675263e-07 8.53211066677984e-06 1.44868504396897 0.551282051282051 9.3 9 3 increased circulating LDL cholesterol level 4.4443368702281e-05 0.000719118991751772 1.44799748580857 0.551020408163265 9.3 9 3 abnormal vertebrae morphology 1.38325150354817e-09 7.6463069223913e-08 1.44652144351926 0.55045871559633 9.3 9 3 muscular ventricular septal defect 6.88230888889471e-06 0.00014207255901349 1.445316008983 0.55 9.3 9 3 abnormal vascular regression 0.00878114435424911 0.0501563641359235 1.445316008983 0.55 9.3 9 3 anencephaly 0.00878114435424911 0.0501563641359235 1.445316008983 0.55 9.3 9 3 abnormal response to tactile stimuli 0.00878114435424911 0.0501563641359235 1.445316008983 0.55 9.3 9 3 abnormal sperm mitochondrial sheath morphology 0.00878114435424911 0.0501563641359235 1.445316008983 0.55 9.3 9 3 decreased muscle cell glucose uptake 0.00878114435424911 0.0501563641359235 1.445316008983 0.55 9.3 9 3 pale kidney 0.00123357379353132 0.0113438625190727 1.44107754561354 0.548387096774194 9.3 9 3 small cranium 0.00123357379353132 0.0113438625190727 1.44107754561354 0.548387096774194 9.3 9 3 abnormal rib morphology 2.30638835695921e-11 1.76527416551878e-09 1.44044962511437 0.548148148148148 9.3 9 3 decreased caudal vertebrae number 4.34825330643266e-06 9.74439648626237e-05 1.43710398620468 0.546875 9.3 9 3 kyphosis 2.38782685661839e-12 2.28450742532241e-10 1.43655651801946 0.546666666666667 9.3 9 3 short snout 2.79050492702433e-09 1.38827620119461e-07 1.43558324124574 0.546296296296296 9.3 9 3 abnormal skin morphology 3.45498438743563e-06 8.18502253690109e-05 1.43337124857818 0.545454545454545 9.3 9 3 abnormal aorta morphology 0.000969121194948842 0.00914872475307493 1.43337124857818 0.545454545454545 9.3 9 3 enlarged pericardium 0.000969121194948842 0.00914872475307493 1.43337124857818 0.545454545454545 9.3 9 3 increased osteoblast cell number 0.000969121194948842 0.00914872475307493 1.43337124857818 0.545454545454545 9.3 9 3 muscular atrophy 0.000144589121956013 0.00197076953898949 1.43337124857818 0.545454545454545 9.3 9 3 abnormal basisphenoid bone morphology 0.0068192299960952 0.0420914010304884 1.43337124857818 0.545454545454545 9.3 9 3 abnormal long bone epiphysis morphology 0.0068192299960952 0.0420914010304884 1.43337124857818 0.545454545454545 9.3 9 3 testis hypoplasia 0.0068192299960952 0.0420914010304884 1.43337124857818 0.545454545454545 9.3 9 3 increased skin papilloma incidence 0.0068192299960952 0.0420914010304884 1.43337124857818 0.545454545454545 9.3 9 3 cleft upper lip 0.0068192299960952 0.0420914010304884 1.43337124857818 0.545454545454545 9.3 9 3 failure of palatal shelf elevation 0.0068192299960952 0.0420914010304884 1.43337124857818 0.545454545454545 9.3 9 3 abnormal ear position 0.0537426417831973 0.188554049979835 1.43337124857818 0.545454545454545 9.3 9 3 abnormal sphenoid bone morphology 0.0537426417831973 0.188554049979835 1.43337124857818 0.545454545454545 9.3 9 3 abnormal enteric ganglia morphology 0.0537426417831973 0.188554049979835 1.43337124857818 0.545454545454545 9.3 9 3 abnormal eye distance/ position 0.0537426417831973 0.188554049979835 1.43337124857818 0.545454545454545 9.3 9 3 abnormal hemoglobin 0.0537426417831973 0.188554049979835 1.43337124857818 0.545454545454545 9.3 9 3 failure of somite differentiation 0.0537426417831973 0.188554049979835 1.43337124857818 0.545454545454545 9.3 9 3 loss of cortex neurons 0.0537426417831973 0.188554049979835 1.43337124857818 0.545454545454545 9.3 9 3 abnormal lymph circulation 0.0537426417831973 0.188554049979835 1.43337124857818 0.545454545454545 9.3 9 3 pathological neovascularization 0.0537426417831973 0.188554049979835 1.43337124857818 0.545454545454545 9.3 9 3 abnormal hair medulla 0.0537426417831973 0.188554049979835 1.43337124857818 0.545454545454545 9.3 9 3 abnormal palatal shelf elevation 0.0537426417831973 0.188554049979835 1.43337124857818 0.545454545454545 9.3 9 3 decreased palatine bone horizontal plate size 0.0537426417831973 0.188554049979835 1.43337124857818 0.545454545454545 9.3 9 3 aorta dilation 0.0537426417831973 0.188554049979835 1.43337124857818 0.545454545454545 9.3 9 3 abnormal pulmonary alveolar sac morphology 0.0537426417831973 0.188554049979835 1.43337124857818 0.545454545454545 9.3 9 3 decreased core body temperature 0.0537426417831973 0.188554049979835 1.43337124857818 0.545454545454545 9.3 9 3 chylous ascites 0.0537426417831973 0.188554049979835 1.43337124857818 0.545454545454545 9.3 9 3 reduced sympathetic cervical ganglion size 0.0537426417831973 0.188554049979835 1.43337124857818 0.545454545454545 9.3 9 3 abnormal cranium morphology 4.63122445220184e-11 3.43885696264241e-09 1.43158844851776 0.544776119402985 9.3 9 3 abnormal myocardium layer morphology 4.33488235258263e-07 1.31500242098162e-05 1.43034725860227 0.544303797468354 9.3 9 3 embryonic lethality before implantation, complete penetrance 2.28514805840565e-10 1.42107644882102e-08 1.42954892524864 0.544 9.3 9 3 delayed wound healing 0.000114239265748066 0.00161460325879724 1.42817787448913 0.543478260869565 9.3 9 3 decreased heart weight 3.44818428833188e-07 1.05893313792908e-05 1.42747260146469 0.54320987654321 9.3 9 3 thick pulmonary interalveolar septum 0.000761550299094149 0.00766945898379229 1.426545671204 0.542857142857143 9.3 9 3 ovary cysts 0.000761550299094149 0.00766945898379229 1.426545671204 0.542857142857143 9.3 9 3 increased red blood cell distribution width 0.000761550299094149 0.00766945898379229 1.426545671204 0.542857142857143 9.3 9 3 abnormal thoracic vertebrae morphology 1.39237305729729e-05 0.000255019993258666 1.42527310593084 0.542372881355932 9.3 9 3 small heart 9.02582668691938e-05 0.00132069081668894 1.42341728157416 0.541666666666667 9.3 9 3 abnormal adrenal gland morphology 0.00530250433267635 0.0357452019716326 1.42341728157416 0.541666666666667 9.3 9 3 abnormal body weight 0.00530250433267635 0.0357452019716326 1.42341728157416 0.541666666666667 9.3 9 3 increased hemangiosarcoma incidence 0.00530250433267635 0.0357452019716326 1.42341728157416 0.541666666666667 9.3 9 3 abnormal lung saccule morphology 0.00530250433267635 0.0357452019716326 1.42341728157416 0.541666666666667 9.3 9 3 abnormal long bone metaphysis morphology 0.000598601820558357 0.00643206059887219 1.42045799408648 0.540540540540541 9.3 9 3 increased circulating phosphate level 0.000598601820558357 0.00643206059887219 1.42045799408648 0.540540540540541 9.3 9 3 abnormal breathing pattern 0.000598601820558357 0.00643206059887219 1.42045799408648 0.540540540540541 9.3 9 3 increased erythroid progenitor cell number 0.000598601820558357 0.00643206059887219 1.42045799408648 0.540540540540541 9.3 9 3 increased B cell derived lymphoma incidence 7.13119358062971e-05 0.00108494458910192 1.4190375360924 0.54 9.3 9 3 impaired balance 1.75484922248456e-08 7.46185887338521e-07 1.41697647939509 0.53921568627451 9.3 9 3 abnormal snout morphology 5.63443425194407e-05 0.00088706678491841 1.41499469410923 0.538461538461538 9.3 9 3 ventricular hypoplasia 0.00412808690453852 0.0289256793663086 1.41499469410923 0.538461538461538 9.3 9 3 abnormal Mullerian duct morphology 0.00412808690453852 0.0289256793663086 1.41499469410923 0.538461538461538 9.3 9 3 absent teeth 0.0406068525417036 0.155931169914113 1.41499469410923 0.538461538461538 9.3 9 3 absent common myeloid progenitor cells 0.0406068525417036 0.155931169914113 1.41499469410923 0.538461538461538 9.3 9 3 abnormal grip strength 0.0406068525417036 0.155931169914113 1.41499469410923 0.538461538461538 9.3 9 3 abnormal soleus morphology 0.0406068525417036 0.155931169914113 1.41499469410923 0.538461538461538 9.3 9 3 absent lateral semicircular canal 0.0406068525417036 0.155931169914113 1.41499469410923 0.538461538461538 9.3 9 3 small otic vesicle 0.0406068525417036 0.155931169914113 1.41499469410923 0.538461538461538 9.3 9 3 small interparietal bone 0.0406068525417036 0.155931169914113 1.41499469410923 0.538461538461538 9.3 9 3 abnormal exocrine pancreas morphology 0.0406068525417036 0.155931169914113 1.41499469410923 0.538461538461538 9.3 9 3 abnormal vertebral arch development 0.0406068525417036 0.155931169914113 1.41499469410923 0.538461538461538 9.3 9 3 increased circulating ammonia level 0.0406068525417036 0.155931169914113 1.41499469410923 0.538461538461538 9.3 9 3 increased circulating thyroxine level 0.0406068525417036 0.155931169914113 1.41499469410923 0.538461538461538 9.3 9 3 orthokeratosis 0.0406068525417036 0.155931169914113 1.41499469410923 0.538461538461538 9.3 9 3 absent hypoglossal nerve 0.0406068525417036 0.155931169914113 1.41499469410923 0.538461538461538 9.3 9 3 small spleen 1.0955106958766e-07 3.83814486759582e-06 1.41499469410923 0.538461538461538 9.3 9 3 abnormal definitive hematopoiesis 8.70671004636068e-08 3.09399160576031e-06 1.41282112315053 0.537634408602151 9.3 9 3 internal hemorrhage 5.48989919024761e-06 0.000118234841867887 1.41197764785313 0.537313432835821 9.3 9 3 abnormal osteoblast physiology 4.45203315496574e-05 0.000719118991751772 1.41125132190259 0.537037037037037 9.3 9 3 abnormal embryo development 1.16235594513358e-10 7.71029443605277e-09 1.41053567721603 0.536764705882353 9.3 9 3 sparse hair 5.45842056951533e-07 1.58804925925958e-05 1.4100643990078 0.536585365853659 9.3 9 3 abnormal developmental patterning 5.45842056951533e-07 1.58804925925958e-05 1.4100643990078 0.536585365853659 9.3 9 3 short humerus 0.000370165345735072 0.00435922102635934 1.4100643990078 0.536585365853659 9.3 9 3 short ulna 0.000370165345735072 0.00435922102635934 1.4100643990078 0.536585365853659 9.3 9 3 increased bone trabecula number 0.000370165345735072 0.00435922102635934 1.4100643990078 0.536585365853659 9.3 9 3 thymus hypoplasia 9.25336037475507e-11 6.33242144832457e-09 1.40913550282927 0.536231884057971 9.3 9 3 short mandible 3.51796845768337e-05 0.00058731184822063 1.407775333425 0.535714285714286 9.3 9 3 abnormal somite shape 0.00321735735749222 0.0238189774606009 1.407775333425 0.535714285714286 9.3 9 3 preweaning lethality, incomplete penetrance 8.02640446524419e-29 4.43681802384332e-26 1.40708693472895 0.535452322738386 9.3 9 3 corneal opacity 3.446217942903e-06 8.18502253690109e-05 1.40645347865183 0.535211267605634 9.3 9 3 abnormal skeletal muscle fiber morphology 3.446217942903e-06 8.18502253690109e-05 1.40645347865183 0.535211267605634 9.3 9 3 perinatal lethality, complete penetrance 1.08531311669948e-15 1.99978990947404e-13 1.40645347865183 0.535211267605634 9.3 9 3 abnormal pulmonary alveolus morphology 3.47046421643862e-08 1.35949287218757e-06 1.40498765949742 0.534653465346535 9.3 9 3 increased erythrocyte cell number 2.19710696404908e-05 0.000383530075303305 1.40151855416533 0.533333333333333 9.3 9 3 trabecula carnea hypoplasia 0.00022917474045462 0.00293851632412818 1.40151855416533 0.533333333333333 9.3 9 3 small placenta 0.00022917474045462 0.00293851632412818 1.40151855416533 0.533333333333333 9.3 9 3 liver hemorrhage 0.00251012238456966 0.0193610214933862 1.40151855416533 0.533333333333333 9.3 9 3 abnormal cellular respiration 0.00251012238456966 0.0193610214933862 1.40151855416533 0.533333333333333 9.3 9 3 macrocytosis 0.0308660548249903 0.12711149561178 1.40151855416533 0.533333333333333 9.3 9 3 decreased hepatocyte number 0.0308660548249903 0.12711149561178 1.40151855416533 0.533333333333333 9.3 9 3 abnormal enteric neuron morphology 0.0308660548249903 0.12711149561178 1.40151855416533 0.533333333333333 9.3 9 3 abnormal prostate gland morphology 0.0308660548249903 0.12711149561178 1.40151855416533 0.533333333333333 9.3 9 3 absent egg cylinders 0.0308660548249903 0.12711149561178 1.40151855416533 0.533333333333333 9.3 9 3 abnormal coronary vessel morphology 0.0308660548249903 0.12711149561178 1.40151855416533 0.533333333333333 9.3 9 3 herniated liver 0.0308660548249903 0.12711149561178 1.40151855416533 0.533333333333333 9.3 9 3 pericardial effusion 1.73653038203429e-05 0.000308544237522163 1.39869291191903 0.532258064516129 9.3 9 3 hunched posture 1.35777353134106e-06 3.59304431830945e-05 1.39708336886734 0.531645569620253 9.3 9 3 abnormal nervous system morphology 1.35777353134106e-06 3.59304431830945e-05 1.39708336886734 0.531645569620253 9.3 9 3 polydipsia 0.0019602017383727 0.0162804735365679 1.39604387231312 0.53125 9.3 9 3 abnormal lumbar vertebrae morphology 0.0019602017383727 0.0162804735365679 1.39604387231312 0.53125 9.3 9 3 bradykinesia 0.0019602017383727 0.0162804735365679 1.39604387231312 0.53125 9.3 9 3 increased fibroblast apoptosis 0.0019602017383727 0.0162804735365679 1.39604387231312 0.53125 9.3 9 3 increased circulating alkaline phosphatase level 5.9533617606691e-12 5.11042506186438e-10 1.39503004234049 0.530864197530864 9.3 9 3 increased neuron apoptosis 1.07572116265456e-06 2.95674739458918e-05 1.39503004234049 0.530864197530864 9.3 9 3 absent kidney 0.000142049021318748 0.00194146670621091 1.39436794929714 0.530612244897959 9.3 9 3 abnormal epidermis stratum corneum morphology 0.000142049021318748 0.00194146670621091 1.39436794929714 0.530612244897959 9.3 9 3 increased T cell derived lymphoma incidence 0.000142049021318748 0.00194146670621091 1.39436794929714 0.530612244897959 9.3 9 3 hydroencephaly 6.92068289240603e-09 3.2481506971434e-07 1.39390160550139 0.530434782608696 9.3 9 3 abnormal tail morphology 1.08506633691453e-05 0.000206827778779685 1.39355538056212 0.53030303030303 9.3 9 3 pericardial edema 8.57829200697585e-06 0.000172084688446391 1.39121327067882 0.529411764705882 9.3 9 3 abnormal nervous system development 0.00153209257958359 0.0136110010418364 1.39121327067882 0.529411764705882 9.3 9 3 increased incidence of corneal inflammation 0.023573563640136 0.101630224641798 1.39121327067882 0.529411764705882 9.3 9 3 absence seizures 0.023573563640136 0.101630224641798 1.39121327067882 0.529411764705882 9.3 9 3 abnormal melanosome morphology 0.023573563640136 0.101630224641798 1.39121327067882 0.529411764705882 9.3 9 3 increased trabecular bone mass 0.023573563640136 0.101630224641798 1.39121327067882 0.529411764705882 9.3 9 3 kinked tail 5.40053108463688e-08 2.0509650493182e-06 1.39121327067882 0.529411764705882 9.3 9 3 increased kidney weight 0.000111880373398772 0.00159485632567017 1.39121327067882 0.529411764705882 9.3 9 3 short limbs 5.34993725655722e-07 1.57490756516995e-05 1.3894364976639 0.528735632183908 9.3 9 3 abnormal bone structure 9.82933966177097e-14 1.13723173993746e-11 1.38881048437368 0.528497409326425 9.3 9 3 abnormal digit morphology 5.3629885255877e-06 0.000116003773542604 1.38691940255944 0.527777777777778 9.3 9 3 abnormal trophoblast giant cell morphology 0.00119844633968563 0.0110822872489516 1.38691940255944 0.527777777777778 9.3 9 3 abnormal coat/hair pigmentation 1.69701625910164e-08 7.34143990350491e-07 1.38431241120125 0.526785714285714 9.3 9 3 abnormal axial skeleton morphology 3.35404017413672e-06 8.0610385827682e-05 1.38307752055789 0.526315789473684 9.3 9 3 abnormal frontal bone morphology 0.000938156344814368 0.00892414496262234 1.38307752055789 0.526315789473684 9.3 9 3 abnormal compact bone morphology 0.000938156344814368 0.00892414496262234 1.38307752055789 0.526315789473684 9.3 9 3 decreased total retina thickness 0.000938156344814368 0.00892414496262234 1.38307752055789 0.526315789473684 9.3 9 3 enlarged adrenal glands 0.0180737304976267 0.0905506638728025 1.38307752055789 0.526315789473684 9.3 9 3 thin dermal layer 0.0180737304976267 0.0905506638728025 1.38307752055789 0.526315789473684 9.3 9 3 oliguria 0.0180737304976267 0.0905506638728025 1.38307752055789 0.526315789473684 9.3 9 3 abnormal sternebra morphology 0.0180737304976267 0.0905506638728025 1.38307752055789 0.526315789473684 9.3 9 3 abnormal cochlear inner hair cell morphology 0.0180737304976267 0.0905506638728025 1.38307752055789 0.526315789473684 9.3 9 3 decreased susceptibility to weight gain 0.0180737304976267 0.0905506638728025 1.38307752055789 0.526315789473684 9.3 9 3 embryonic lethality between implantation and somite formation, incomplete penetrance 0.0180737304976267 0.0905506638728025 1.38307752055789 0.526315789473684 9.3 9 3 increased mean corpuscular hemoglobin 1.32396401076742e-07 4.54256617487444e-06 1.38028342455676 0.525252525252525 9.3 9 3 abnormal pancreatic beta cell morphology 0.000734904792383805 0.00746153335124374 1.3796198267565 0.525 9.3 9 3 decreased total body fat amount 5.89476105763299e-22 1.83290226635776e-19 1.37686609456736 0.523952095808383 9.3 9 3 abnormal heart morphology 1.24780962001755e-15 2.21709030699547e-13 1.37649143712666 0.523809523809524 9.3 9 3 abnormal muscle morphology 0.00057605588158866 0.00628482019934996 1.37649143712666 0.523809523809524 9.3 9 3 abnormal eye pigmentation 0.0139016048996296 0.0734187732225663 1.37649143712666 0.523809523809524 9.3 9 3 abnormal erythrocyte physiology 0.0139016048996296 0.0734187732225663 1.37649143712666 0.523809523809524 9.3 9 3 osteoporosis 0.000451810472163214 0.00506251598876574 1.37364744655409 0.522727272727273 9.3 9 3 lethality, incomplete penetrance 0.000451810472163214 0.00506251598876574 1.37364744655409 0.522727272727273 9.3 9 3 abnormal hepatocyte morphology 3.27931922229098e-08 1.31569460733045e-06 1.3731093942836 0.522522522522523 9.3 9 3 abnormal cell death 0.000354558894679949 0.00423004916314807 1.37105075950956 0.521739130434783 9.3 9 3 atrial septal defect 0.000354558894679949 0.00423004916314807 1.37105075950956 0.521739130434783 9.3 9 3 abnormal Wolffian duct morphology 0.0107216181501281 0.0597312993246217 1.37105075950956 0.521739130434783 9.3 9 3 abnormal vertebral artery topology 0.0107216181501281 0.0597312993246217 1.37105075950956 0.521739130434783 9.3 9 3 postnatal lethality, incomplete penetrance 1.23204428227811e-35 7.66177538041697e-33 1.3694415450031 0.52112676056338 9.3 9 3 abnormal ovary morphology 1.04129813673851e-05 0.000201574250205217 1.3694415450031 0.52112676056338 9.3 9 3 decreased liver weight 1.04129813673851e-05 0.000201574250205217 1.3694415450031 0.52112676056338 9.3 9 3 cardiac hypertrophy 2.55282397765759e-07 8.24694759016007e-06 1.36755318104143 0.520408163265306 9.3 9 3 abnormal liver physiology 2.02081752857708e-07 6.61418895044143e-06 1.3664805903112 0.52 9.3 9 3 abnormal hindlimb morphology 0.000218680863957235 0.00284800339839593 1.3664805903112 0.52 9.3 9 3 abnormal axon extension 0.000218680863957235 0.00284800339839593 1.3664805903112 0.52 9.3 9 3 mandible hypoplasia 0.00828829217581391 0.0486179949097515 1.3664805903112 0.52 9.3 9 3 abnormal primitive streak morphology 0.00828829217581391 0.0486179949097515 1.3664805903112 0.52 9.3 9 3 abnormal keratinocyte physiology 0.00828829217581391 0.0486179949097515 1.3664805903112 0.52 9.3 9 3 decreased placenta weight 0.00828829217581391 0.0486179949097515 1.3664805903112 0.52 9.3 9 3 increased liver glycogen level 0.00828829217581391 0.0486179949097515 1.3664805903112 0.52 9.3 9 3 distended pericardium 0.00017185928674845 0.00232336943362375 1.36445916931961 0.519230769230769 9.3 9 3 abnormal placenta labyrinth morphology 4.05008821571237e-06 9.21264676431644e-05 1.3638194791324 0.518987341772152 9.3 9 3 decreased bone mineral density 3.75425933035791e-17 8.12062616023069e-15 1.36331927026421 0.518796992481203 9.3 9 3 abnormal mandible morphology 0.000135119861154583 0.00187248275555445 1.36258748321629 0.518518518518518 9.3 9 3 abnormal small intestine morphology 0.000135119861154583 0.00187248275555445 1.36258748321629 0.518518518518518 9.3 9 3 abnormal trigeminal ganglion morphology 0.00642013934557751 0.0403285268235456 1.36258748321629 0.518518518518518 9.3 9 3 abnormal fetal cardiomyocyte proliferation 0.00642013934557751 0.0403285268235456 1.36258748321629 0.518518518518518 9.3 9 3 glomerulosclerosis 8.36217834771644e-05 0.0012493044228195 1.35923135641034 0.517241379310345 9.3 9 3 absent long term depression 0.00498183549194775 0.0341856987206069 1.35923135641034 0.517241379310345 9.3 9 3 decreased bone strength 0.00498183549194775 0.0341856987206069 1.35923135641034 0.517241379310345 9.3 9 3 anophthalmia 1.24817667248024e-06 3.35658321383199e-05 1.35821320558157 0.51685393258427 9.3 9 3 abnormal muscle physiology 1.24817667248024e-06 3.35658321383199e-05 1.35821320558157 0.51685393258427 9.3 9 3 absent mesoderm 6.58193612075085e-05 0.00100445190799802 1.35772109934766 0.516666666666667 9.3 9 3 abnormal long bone epiphyseal plate morphology 6.58193612075085e-05 0.00100445190799802 1.35772109934766 0.516666666666667 9.3 9 3 abnormal object recognition memory 0.00387177421501055 0.027477998173577 1.35630827822451 0.516129032258065 9.3 9 3 abnormal capillary morphology 0.00387177421501055 0.027477998173577 1.35630827822451 0.516129032258065 9.3 9 3 decreased thymus weight 0.00387177421501055 0.027477998173577 1.35630827822451 0.516129032258065 9.3 9 3 abnormal mitochondrial ATP synthesis coupled electron transport 0.00387177421501055 0.027477998173577 1.35630827822451 0.516129032258065 9.3 9 3 decreased brown adipose tissue amount 0.00301322481576055 0.0224749527112575 1.35373951254606 0.515151515151515 9.3 9 3 single kidney 0.00301322481576055 0.0224749527112575 1.35373951254606 0.515151515151515 9.3 9 3 increased carcinoma incidence 0.00234796087657241 0.0185852423682732 1.351464320088 0.514285714285714 9.3 9 3 holoprosencephaly 0.00234796087657241 0.0185852423682732 1.351464320088 0.514285714285714 9.3 9 3 impaired adaptive thermogenesis 0.00234796087657241 0.0185852423682732 1.351464320088 0.514285714285714 9.3 9 3 pale liver 1.24226946386063e-05 0.000233218512554967 1.34943509438216 0.513513513513513 9.3 9 3 abnormal vocalization 0.00183161555431998 0.0156299955107065 1.34943509438216 0.513513513513513 9.3 9 3 abnormal humerus morphology 0.00183161555431998 0.0156299955107065 1.34943509438216 0.513513513513513 9.3 9 3 enlarged heart 1.56047039835934e-14 2.28333536230521e-12 1.34790442844026 0.512931034482759 9.3 9 3 failure of heart looping 0.00143026289873671 0.012937378038573 1.34761399438974 0.512820512820513 9.3 9 3 abnormal bone mineralization 2.93950925144694e-08 1.21867154382904e-06 1.34650026381586 0.512396694214876 9.3 9 3 lethality at weaning, incomplete penetrance 0.00111788121136498 0.0104662318152546 1.34597056268926 0.51219512195122 9.3 9 3 hydronephrosis 3.80243307279094e-06 8.79865327308602e-05 1.34520754082833 0.511904761904762 9.3 9 3 abnormal blood circulation 0.000874458002290685 0.00842851117298033 1.34448000835628 0.511627906976744 9.3 9 3 abnormal autopod morphology 0.000684566009858564 0.0071850546393383 1.34312194774177 0.511111111111111 9.3 9 3 abnormal ovarian follicle morphology 0.000684566009858564 0.0071850546393383 1.34312194774177 0.511111111111111 9.3 9 3 embryonic growth arrest 3.70045443511101e-14 4.97561103099386e-12 1.34261193371187 0.510917030567686 9.3 9 3 abnormal locomotor behavior 1.47962073663667e-06 3.89476887024731e-05 1.34248720201978 0.510869565217391 9.3 9 3 abnormal blood vessel morphology 1.78796137883087e-09 9.56463210718662e-08 1.3411082716582 0.510344827586207 9.3 9 3 abnormal long bone hypertrophic chondrocyte zone 0.000420400261869764 0.00487588013371597 1.34073841278571 0.510204081632653 9.3 9 3 respiratory failure 8.88837585296185e-10 5.08272067453853e-08 1.3400280877988 0.509933774834437 9.3 9 3 abnormal dendritic spine morphology 0.000329753374138038 0.00399154023439595 1.33968685324627 0.509803921568627 9.3 9 3 abnormal rostral-caudal axis patterning 0.000203213012845621 0.00268548711935741 1.33781316533963 0.509090909090909 9.3 9 3 abnormal craniofacial bone morphology 0.000159644913284588 0.00217003673112247 1.3369749365393 0.508771929824561 9.3 9 3 abnormal kidney morphology 5.44374853031112e-11 3.92502158526055e-09 1.3364480498648 0.508571428571429 9.3 9 3 increased tumor incidence 3.46119989156913e-08 1.35949287218757e-06 1.33511596137725 0.508064516129032 9.3 9 3 decreased susceptibility to hepatic steatosis 7.76053782235383e-05 0.00117351597769636 1.33477957539555 0.507936507936508 9.3 9 3 abnormal lipid homeostasis 1.71611814017037e-08 7.36007564426516e-07 1.33413785444584 0.507692307692308 9.3 9 3 abnormal behavior 2.08505543497339e-16 4.14926031559705e-14 1.33282902071028 0.507194244604317 9.3 9 3 decreased bone marrow cell number 2.34909804189114e-05 0.000408628068475818 1.33192259856465 0.506849315068493 9.3 9 3 increased startle reflex 3.51972245030875e-06 8.29887165416399e-05 1.32868683154719 0.50561797752809 9.3 9 3 increased bone mineral content 3.33476785934448e-07 1.03046398138129e-05 1.32597798989266 0.504587155963303 9.3 9 3 abnormal testis morphology 1.64864356792773e-07 5.50469916136944e-06 1.32534906752591 0.504347826086956 9.3 9 3 premature death 7.00854127459427e-47 6.9734985682213e-44 1.32460595058309 0.504065040650406 9.3 9 3 decreased hemoglobin content 7.86002866241919e-09 3.62070764773477e-07 1.32324225193801 0.50354609929078 9.3 9 3 abnormal liver morphology 9.35804068249392e-11 6.33242144832457e-09 1.32126400008603 0.502793296089385 9.3 9 3 small testis 1.93692461308658e-15 3.21206665003524e-13 1.31392364453 0.5 9.3 9 3 insulin resistance 3.70139677856965e-08 1.43862882604562e-06 1.31392364453 0.5 9.3 9 3 extramedullary hematopoiesis 7.82126365245672e-07 2.20167022816002e-05 1.31392364453 0.5 9.3 9 3 increased oxygen consumption 8.29737869077662e-06 0.000167123315735278 1.31392364453 0.5 9.3 9 3 abnormal intestine morphology 3.45592661992164e-05 0.000578896799128289 1.31392364453 0.5 9.3 9 3 abnormal eating behavior 0.000185129115221197 0.0024692154107921 1.31392364453 0.5 9.3 9 3 increased cell proliferation 0.000382472397381042 0.0044666670820908 1.31392364453 0.5 9.3 9 3 impaired limb coordination 0.000382472397381042 0.0044666670820908 1.31392364453 0.5 9.3 9 3 thin skin 0.00449435705193748 0.0310547587963736 1.31392364453 0.5 9.3 9 3 abnormal spleen red pulp morphology 0.00449435705193748 0.0310547587963736 1.31392364453 0.5 9.3 9 3 increased width of hypertrophic chondrocyte zone 0.00449435705193748 0.0310547587963736 1.31392364453 0.5 9.3 9 3 failure of primitive streak formation 0.0057833466916484 0.0371733201433472 1.31392364453 0.5 9.3 9 3 abnormal spongiotrophoblast layer morphology 0.0057833466916484 0.0371733201433472 1.31392364453 0.5 9.3 9 3 abnormal optic cup morphology 0.00745354859932583 0.0442498857776206 1.31392364453 0.5 9.3 9 3 abnormal fat pad morphology 0.00745354859932583 0.0442498857776206 1.31392364453 0.5 9.3 9 3 abnormal stomach morphology 0.0124484974470893 0.0675368318421695 1.31392364453 0.5 9.3 9 3 heart inflammation 0.0124484974470893 0.0675368318421695 1.31392364453 0.5 9.3 9 3 decreased circulating glycerol level 0.0124484974470893 0.0675368318421695 1.31392364453 0.5 9.3 9 3 decreased bone resorption 0.0124484974470893 0.0675368318421695 1.31392364453 0.5 9.3 9 3 abnormal malleus morphology 0.0161407319675798 0.0835986889857357 1.31392364453 0.5 9.3 9 3 apnea 0.0161407319675798 0.0835986889857357 1.31392364453 0.5 9.3 9 3 abnormal impulse conducting system conduction 0.0161407319675798 0.0835986889857357 1.31392364453 0.5 9.3 9 3 abnormal osteoblast morphology 0.0161407319675798 0.0835986889857357 1.31392364453 0.5 9.3 9 3 abnormal circulating enzyme level 0.0273663166410042 0.114602209839222 1.31392364453 0.5 9.3 9 3 increased urine glucose level 0.0273663166410042 0.114602209839222 1.31392364453 0.5 9.3 9 3 abnormal fibula morphology 0.0273663166410042 0.114602209839222 1.31392364453 0.5 9.3 9 3 abnormal induced retinal neovascularization 0.0273663166410042 0.114602209839222 1.31392364453 0.5 9.3 9 3 absent mandible 0.0471105556196322 0.176221815193737 1.31392364453 0.5 9.3 9 3 decreased mast cell number 0.0471105556196322 0.176221815193737 1.31392364453 0.5 9.3 9 3 abnormal hair follicle orientation 0.0471105556196322 0.176221815193737 1.31392364453 0.5 9.3 9 3 disorganized retinal layers 0.0471105556196322 0.176221815193737 1.31392364453 0.5 9.3 9 3 reduced male mating frequency 0.0471105556196322 0.176221815193737 1.31392364453 0.5 9.3 9 3 poor circulation 0.0471105556196322 0.176221815193737 1.31392364453 0.5 9.3 9 3 abnormal olfaction 0.0471105556196322 0.176221815193737 1.31392364453 0.5 9.3 9 3 abnormal pulmonary elastic fiber morphology 0.0471105556196322 0.176221815193737 1.31392364453 0.5 9.3 9 3 small pancreas 0.0471105556196322 0.176221815193737 1.31392364453 0.5 9.3 9 3 decreased skeletal muscle weight 0.0471105556196322 0.176221815193737 1.31392364453 0.5 9.3 9 3 abnormal adipose tissue distribution 0.0830069227421734 0.239258076849544 1.31392364453 0.5 9.3 9 3 mesocardia 0.0830069227421734 0.239258076849544 1.31392364453 0.5 9.3 9 3 abnormal superior cervical ganglion morphology 0.0830069227421734 0.239258076849544 1.31392364453 0.5 9.3 9 3 abnormal mating frequency 0.0830069227421734 0.239258076849544 1.31392364453 0.5 9.3 9 3 abnormal thymus involution 0.0830069227421734 0.239258076849544 1.31392364453 0.5 9.3 9 3 increased litter size 0.0830069227421734 0.239258076849544 1.31392364453 0.5 9.3 9 3 abnormal tracheal ciliated epithelium morphology 0.0830069227421734 0.239258076849544 1.31392364453 0.5 9.3 9 3 increased growth rate 0.0830069227421734 0.239258076849544 1.31392364453 0.5 9.3 9 3 abnormal corticospinal tract morphology 0.0830069227421734 0.239258076849544 1.31392364453 0.5 9.3 9 3 abnormal AMPA-mediated synaptic currents 0.0830069227421734 0.239258076849544 1.31392364453 0.5 9.3 9 3 abnormal gastrocnemius morphology 0.0830069227421734 0.239258076849544 1.31392364453 0.5 9.3 9 3 abnormal vascular endothelial cell development 0.0830069227421734 0.239258076849544 1.31392364453 0.5 9.3 9 3 decreased left ventricle systolic pressure 0.0830069227421734 0.239258076849544 1.31392364453 0.5 9.3 9 3 stria vascularis degeneration 0.0830069227421734 0.239258076849544 1.31392364453 0.5 9.3 9 3 abnormal amacrine cell morphology 0.0830069227421734 0.239258076849544 1.31392364453 0.5 9.3 9 3 hemoperitoneum 0.0830069227421734 0.239258076849544 1.31392364453 0.5 9.3 9 3 reduced cerebellar foliation 0.0830069227421734 0.239258076849544 1.31392364453 0.5 9.3 9 3 decreased prostaglandin level 0.0830069227421734 0.239258076849544 1.31392364453 0.5 9.3 9 3 increased fibrosarcoma incidence 0.0830069227421734 0.239258076849544 1.31392364453 0.5 9.3 9 3 increased skeletal muscle glycogen level 0.0830069227421734 0.239258076849544 1.31392364453 0.5 9.3 9 3 abnormal vitelline vein connection 0.0830069227421734 0.239258076849544 1.31392364453 0.5 9.3 9 3 kidney hemorrhage 0.111663749121004 0.301752934208036 1.31392364453 0.5 9.3 9 3 abnormal prostate gland epithelium morphology 0.111663749121004 0.301752934208036 1.31392364453 0.5 9.3 9 3 fused cornea and lens 0.111663749121004 0.301752934208036 1.31392364453 0.5 9.3 9 3 absent trophoblast giant cells 0.111663749121004 0.301752934208036 1.31392364453 0.5 9.3 9 3 abnormal primordial germ cell migration 0.111663749121004 0.301752934208036 1.31392364453 0.5 9.3 9 3 peritoneal inflammation 0.111663749121004 0.301752934208036 1.31392364453 0.5 9.3 9 3 abnormal hypaxial muscle morphology 0.111663749121004 0.301752934208036 1.31392364453 0.5 9.3 9 3 increased left ventricle diastolic pressure 0.111663749121004 0.301752934208036 1.31392364453 0.5 9.3 9 3 abnormal gas homeostasis 0.111663749121004 0.301752934208036 1.31392364453 0.5 9.3 9 3 abnormal deltoid tuberosity morphology 0.111663749121004 0.301752934208036 1.31392364453 0.5 9.3 9 3 decreased cochlear inner hair cell number 0.111663749121004 0.301752934208036 1.31392364453 0.5 9.3 9 3 ascites 0.111663749121004 0.301752934208036 1.31392364453 0.5 9.3 9 3 abnormal gonadal fat pad morphology 0.111663749121004 0.301752934208036 1.31392364453 0.5 9.3 9 3 vascular smooth muscle hyperplasia 0.111663749121004 0.301752934208036 1.31392364453 0.5 9.3 9 3 abnormal developmental vascular remodeling 0.111663749121004 0.301752934208036 1.31392364453 0.5 9.3 9 3 abnormal sperm principal piece morphology 0.111663749121004 0.301752934208036 1.31392364453 0.5 9.3 9 3 increased serotonin level 0.111663749121004 0.301752934208036 1.31392364453 0.5 9.3 9 3 umbilical hernia 0.111663749121004 0.301752934208036 1.31392364453 0.5 9.3 9 3 acanthocytosis 0.111663749121004 0.301752934208036 1.31392364453 0.5 9.3 9 3 abnormal vibrissa follicle morphology 0.111663749121004 0.301752934208036 1.31392364453 0.5 9.3 9 3 abnormal inferior vena cava valve morphology 0.111663749121004 0.301752934208036 1.31392364453 0.5 9.3 9 3 thick aortic valve 0.111663749121004 0.301752934208036 1.31392364453 0.5 9.3 9 3 abnormal pulmonary interalveolar septum morphology 0.111663749121004 0.301752934208036 1.31392364453 0.5 9.3 9 3 increased compact bone area 0.111663749121004 0.301752934208036 1.31392364453 0.5 9.3 9 3 decreased circulating lactate level 0.111663749121004 0.301752934208036 1.31392364453 0.5 9.3 9 3 thin ventricular wall 5.16650082726622e-06 0.000113104184410481 1.31392364453 0.5 9.3 9 3 hyperglycemia 6.54673436147864e-06 0.000137876620584666 1.31392364453 0.5 9.3 9 3 abnormal neuromuscular synapse morphology 4.38777245157312e-05 0.000713371501522101 1.31392364453 0.5 9.3 9 3 decreased blood urea nitrogen level 0.00129710553241816 0.0118623162201845 1.31392364453 0.5 9.3 9 3 spina bifida 0.0016597065411413 0.0144860351617158 1.31392364453 0.5 9.3 9 3 incomplete somite formation 0.00272507476382558 0.0207933235429943 1.31392364453 0.5 9.3 9 3 hyporesponsive to tactile stimuli 0.00272507476382558 0.0207933235429943 1.31392364453 0.5 9.3 9 3 reduced long term depression 0.0034974754134592 0.0254757542927665 1.31392364453 0.5 9.3 9 3 abnormal lysosome morphology 0.0034974754134592 0.0254757542927665 1.31392364453 0.5 9.3 9 3 narrow eye opening 0.0034974754134592 0.0254757542927665 1.31392364453 0.5 9.3 9 3 straub tail 0.00962292133366281 0.054340560312114 1.31392364453 0.5 9.3 9 3 abnormal hormone level 0.00962292133366281 0.054340560312114 1.31392364453 0.5 9.3 9 3 abnormal brainstem morphology 0.00962292133366281 0.054340560312114 1.31392364453 0.5 9.3 9 3 corneal vascularization 0.00962292133366281 0.054340560312114 1.31392364453 0.5 9.3 9 3 abnormal circulating lipid level 0.020983979803164 0.0943899634003083 1.31392364453 0.5 9.3 9 3 abnormal limb posture 0.020983979803164 0.0943899634003083 1.31392364453 0.5 9.3 9 3 abnormal blood-brain barrier function 0.020983979803164 0.0943899634003083 1.31392364453 0.5 9.3 9 3 abnormal mesenteric lymph node morphology 0.020983979803164 0.0943899634003083 1.31392364453 0.5 9.3 9 3 increased adenoma incidence 0.020983979803164 0.0943899634003083 1.31392364453 0.5 9.3 9 3 abnormal radius morphology 0.0358240788503528 0.143152443598799 1.31392364453 0.5 9.3 9 3 abnormal mammary gland morphology 0.0358240788503528 0.143152443598799 1.31392364453 0.5 9.3 9 3 thick dermal layer 0.0358240788503528 0.143152443598799 1.31392364453 0.5 9.3 9 3 abnormal thyroid cartilage morphology 0.0358240788503528 0.143152443598799 1.31392364453 0.5 9.3 9 3 abnormal Peyer's patch follicle morphology 0.0358240788503528 0.143152443598799 1.31392364453 0.5 9.3 9 3 abnormal bile duct morphology 0.0358240788503528 0.143152443598799 1.31392364453 0.5 9.3 9 3 increased circulating renin level 0.0358240788503528 0.143152443598799 1.31392364453 0.5 9.3 9 3 increased circulating glycerol level 0.0358240788503528 0.143152443598799 1.31392364453 0.5 9.3 9 3 darkened coat color 0.0358240788503528 0.143152443598799 1.31392364453 0.5 9.3 9 3 jerky movement 0.0358240788503528 0.143152443598799 1.31392364453 0.5 9.3 9 3 small thoracic cage 0.0358240788503528 0.143152443598799 1.31392364453 0.5 9.3 9 3 abnormal hypoglossal nerve topology 0.0358240788503528 0.143152443598799 1.31392364453 0.5 9.3 9 3 megacephaly 0.0623063960033874 0.213334012468584 1.31392364453 0.5 9.3 9 3 irregularly shaped pupil 0.0623063960033874 0.213334012468584 1.31392364453 0.5 9.3 9 3 abnormal fluid regulation 0.0623063960033874 0.213334012468584 1.31392364453 0.5 9.3 9 3 abnormal kidney medulla morphology 0.0623063960033874 0.213334012468584 1.31392364453 0.5 9.3 9 3 abnormal ventral body wall morphology 0.0623063960033874 0.213334012468584 1.31392364453 0.5 9.3 9 3 abnormal imprinting 0.0623063960033874 0.213334012468584 1.31392364453 0.5 9.3 9 3 skeletal muscle necrosis 0.0623063960033874 0.213334012468584 1.31392364453 0.5 9.3 9 3 abnormal maternal decidual layer morphology 0.0623063960033874 0.213334012468584 1.31392364453 0.5 9.3 9 3 increased pulmonary respiratory rate 0.0623063960033874 0.213334012468584 1.31392364453 0.5 9.3 9 3 pulmonary alveolar hemorrhage 0.0623063960033874 0.213334012468584 1.31392364453 0.5 9.3 9 3 testis degeneration 0.0623063960033874 0.213334012468584 1.31392364453 0.5 9.3 9 3 multiple persisting craniopharyngeal ducts 0.0623063960033874 0.213334012468584 1.31392364453 0.5 9.3 9 3 thrombocytopenia 1.32137634569388e-08 5.81756399984696e-07 1.30486210215393 0.496551724137931 9.3 9 3 impaired glucose tolerance 1.33219285995235e-13 1.50628624505976e-11 1.30332748610637 0.495967741935484 9.3 9 3 abnormal nervous system physiology 4.43410716049876e-07 1.3369504923322e-05 1.30249822153408 0.495652173913044 9.3 9 3 abnormal neuron morphology 2.91528730425304e-06 7.07490455544336e-05 1.30065168852464 0.494949494949495 9.3 9 3 lethargy 5.92173007482669e-06 0.000126440373915291 1.29979543329849 0.494623655913978 9.3 9 3 abnormal glucose homeostasis 2.86792422244661e-10 1.76147197613233e-08 1.29948492316154 0.494505494505495 9.3 9 3 increased grip strength 7.50226302858995e-06 0.000153595714268457 1.29948492316154 0.494505494505495 9.3 9 3 decreased B cell proliferation 3.11581950217082e-05 0.000532687354752571 1.29729169966253 0.493670886075949 9.3 9 3 abnormal seminiferous tubule morphology 1.90620808543077e-08 8.03676713984583e-07 1.29592469049534 0.493150684931507 9.3 9 3 astrocytosis 6.37134755288538e-05 0.000981345327418104 1.29592469049534 0.493150684931507 9.3 9 3 atelectasis 8.09178737839551e-05 0.00121621275551413 1.29541767770563 0.492957746478873 9.3 9 3 increased circulating free fatty acid level 8.09178737839551e-05 0.00121621275551413 1.29541767770563 0.492957746478873 9.3 9 3 anemia 1.58857285837025e-11 1.25446824926857e-09 1.29524226569782 0.492890995260663 9.3 9 3 abnormal femur morphology 0.000130649846468473 0.00182068063355925 1.29431284386537 0.492537313432836 9.3 9 3 neonatal lethality, incomplete penetrance 8.63433120386032e-14 1.02275708902869e-11 1.29370943461415 0.492307692307692 9.3 9 3 increased B cell proliferation 0.000342188721140417 0.00411527054818943 1.29165375224983 0.491525423728814 9.3 9 3 decreased body size 4.15255659009517e-39 2.95128129081764e-36 1.2908723525207 0.491228070175439 9.3 9 3 absent vitelline blood vessels 0.000435808737932022 0.00493142099032697 1.2908723525207 0.491228070175439 9.3 9 3 increased hepatocellular carcinoma incidence 0.000435808737932022 0.00493142099032697 1.2908723525207 0.491228070175439 9.3 9 3 abnormal head morphology 0.000555329661040196 0.00607201112895599 1.29003412372036 0.490909090909091 9.3 9 3 abnormal mesoderm development 0.000708022818518553 0.00740002840783571 1.28913263236905 0.490566037735849 9.3 9 3 abnormal gastrulation 0.000903241088286385 0.00865823586555831 1.28816043581372 0.490196078431373 9.3 9 3 abnormal gluconeogenesis 0.000903241088286385 0.00865823586555831 1.28816043581372 0.490196078431373 9.3 9 3 abnormal tibia morphology 0.00147292986979188 0.0132750472866207 1.28596782230595 0.48936170212766 9.3 9 3 abnormal innervation 0.00147292986979188 0.0132750472866207 1.28596782230595 0.48936170212766 9.3 9 3 abnormal cartilage development 0.00188301290182299 0.0157710255666151 1.28472534131822 0.488888888888889 9.3 9 3 abnormal cell migration 0.00188301290182299 0.0157710255666151 1.28472534131822 0.488888888888889 9.3 9 3 abnormal cardiovascular system physiology 1.40147924768233e-07 4.74310153552352e-06 1.28428626908947 0.488721804511278 9.3 9 3 short femur 1.73058588927281e-05 0.000308544237522163 1.28406174351795 0.488636363636364 9.3 9 3 increased tumor growth/size 0.00308537318958929 0.022978640147016 1.28187672637073 0.48780487804878 9.3 9 3 decreased circulating glucose level 3.9199243544243e-14 5.13200622717393e-12 1.28095781832315 0.487455197132616 9.3 9 3 abnormal heart development 1.21343182621641e-08 5.39002083520235e-07 1.28065975479506 0.487341772151899 9.3 9 3 absent gastric milk in neonates 5.67121879657434e-05 0.000890041435739978 1.28023329467025 0.487179487179487 9.3 9 3 reduced female fertility 5.71722311721435e-12 5.07914018002525e-10 1.27994286061974 0.487068965517241 9.3 9 3 increased granulocyte number 9.13332527885083e-05 0.00132860506614862 1.27841219467783 0.486486486486487 9.3 9 3 small seminiferous tubules 9.13332527885083e-05 0.00132860506614862 1.27841219467783 0.486486486486487 9.3 9 3 abnormal hair follicle development 0.00507565843790688 0.0347337011397341 1.27841219467783 0.486486486486487 9.3 9 3 skin inflammation 0.00507565843790688 0.0347337011397341 1.27841219467783 0.486486486486487 9.3 9 3 abnormal hippocampus pyramidal cell morphology 0.00652150899533782 0.0409136283124914 1.276382968972 0.485714285714286 9.3 9 3 respiratory distress 3.37812262224705e-09 1.64766274957638e-07 1.27594897272277 0.485549132947977 9.3 9 3 abnormal motor coordination/ balance 7.55981198044415e-06 0.000154139609027498 1.27410777651394 0.484848484848485 9.3 9 3 abnormal ovarian folliculogenesis 0.00839052022189581 0.0486179949097515 1.27410777651394 0.484848484848485 9.3 9 3 abnormal locomotor coordination 0.00839052022189581 0.0486179949097515 1.27410777651394 0.484848484848485 9.3 9 3 abnormal QRS complex 0.00839052022189581 0.0486179949097515 1.27410777651394 0.484848484848485 9.3 9 3 abnormal middle ear ossicle morphology 0.00839052022189581 0.0486179949097515 1.27410777651394 0.484848484848485 9.3 9 3 cardiovascular system phenotype 0.00839052022189581 0.0486179949097515 1.27410777651394 0.484848484848485 9.3 9 3 reduced male fertility 1.62319836644177e-11 1.26178310516372e-09 1.27340617531542 0.484581497797357 9.3 9 3 abnormal myocardial fiber morphology 9.56853690121837e-06 0.000188902663030005 1.27328683078165 0.484536082474227 9.3 9 3 abnormal incisor morphology 0.000489115449258399 0.00544373458626518 1.27012618971233 0.483333333333333 9.3 9 3 decreased rib number 2.45965832560297e-05 0.000426369343898075 1.26963408347842 0.48314606741573 9.3 9 3 abnormal outer ear morphology 0.0139546014525968 0.0736205113750468 1.26861593264965 0.482758620689655 9.3 9 3 postnatal growth retardation 6.01563394116005e-28 2.99277788572713e-25 1.26669109521683 0.48202614379085 9.3 9 3 neurodegeneration 0.00101031963814625 0.00951958371169999 1.2652598058437 0.481481481481481 9.3 9 3 abnormal brain commissure morphology 0.0180462585413503 0.0905506638728025 1.2652598058437 0.481481481481481 9.3 9 3 decreased cardiac muscle contractility 6.66891551938051e-06 0.000138241061287159 1.26338811974038 0.480769230769231 9.3 9 3 cachexia 6.66891551938051e-06 0.000138241061287159 1.26338811974038 0.480769230769231 9.3 9 3 increased monocyte cell number 1.06679282106215e-05 0.000204126703260932 1.2613666987488 0.48 9.3 9 3 enlarged liver 1.06679282106215e-05 0.000204126703260932 1.2613666987488 0.48 9.3 9 3 spleen hyperplasia 0.000129318475221459 0.0018071893658055 1.2613666987488 0.48 9.3 9 3 ruffled hair 0.0233891379292099 0.101271506699582 1.2613666987488 0.48 9.3 9 3 abnormal thyroid gland morphology 0.0233891379292099 0.101271506699582 1.2613666987488 0.48 9.3 9 3 increased cellular sensitivity to ionizing radiation 0.0233891379292099 0.101271506699582 1.2613666987488 0.48 9.3 9 3 retinal degeneration 1.70734486593411e-05 0.000306644068881667 1.25917682600791 0.479166666666667 9.3 9 3 oligodactyly 0.00209736932684916 0.0171515375683959 1.25917682600791 0.479166666666667 9.3 9 3 decreased spleen weight 0.000264339171920374 0.00332933514000977 1.25679652955043 0.478260869565217 9.3 9 3 abnormal circulating insulin level 0.0303911446517802 0.126206965477969 1.25679652955043 0.478260869565217 9.3 9 3 hypotension 0.0303911446517802 0.126206965477969 1.25679652955043 0.478260869565217 9.3 9 3 abnormal postnatal growth 0.0303911446517802 0.126206965477969 1.25679652955043 0.478260869565217 9.3 9 3 conjunctivitis 0.0303911446517802 0.126206965477969 1.25679652955043 0.478260869565217 9.3 9 3 abnormal basicranium morphology 0.0303911446517802 0.126206965477969 1.25679652955043 0.478260869565217 9.3 9 3 decreased white adipose tissue amount 0.000335674972928026 0.0040533567726139 1.25509124253612 0.477611940298507 9.3 9 3 abnormal astrocyte morphology 0.00342470914178963 0.0250557764417697 1.25419984250591 0.477272727272727 9.3 9 3 microphthalmia 8.58349947344578e-08 3.07215178995631e-06 1.25380949085869 0.477124183006536 9.3 9 3 disheveled coat 0.00438143377908744 0.0305717153589902 1.25135585193333 0.476190476190476 9.3 9 3 abnormal pancreas morphology 0.00438143377908744 0.0305717153589902 1.25135585193333 0.476190476190476 9.3 9 3 abnormal embryonic/fetal subventricular zone morphology 0.0396069636786175 0.155931169914113 1.25135585193333 0.476190476190476 9.3 9 3 increased acute inflammation 0.0396069636786175 0.155931169914113 1.25135585193333 0.476190476190476 9.3 9 3 embryonic lethality at implantation, complete penetrance 0.0396069636786175 0.155931169914113 1.25135585193333 0.476190476190476 9.3 9 3 decreased body weight 1.13628148095429e-52 2.8265001838738e-49 1.25024398485972 0.475767366720517 9.3 9 3 enlarged spleen 3.35332184769061e-13 3.70728359828018e-11 1.25005235625423 0.475694444444444 9.3 9 3 increased osteoclast cell number 0.000688767500190325 0.00721393329146708 1.24930444889737 0.475409836065574 9.3 9 3 liver inflammation 2.53648236783441e-06 6.30949988998809e-05 1.2482274623035 0.475 9.3 9 3 abnormal retinal pigment epithelium morphology 0.000112686874989607 0.00160176343735227 1.2482274623035 0.475 9.3 9 3 impaired ovarian folliculogenesis 0.00561043058712846 0.0371733201433472 1.2482274623035 0.475 9.3 9 3 increased hemoglobin content 0.000875887492749916 0.00842851117298033 1.24711396768949 0.474576271186441 9.3 9 3 decreased brain weight 0.00111430372413288 0.0104597377878511 1.2447697685021 0.473684210526316 9.3 9 3 abnormal facial morphology 0.00111430372413288 0.0104597377878511 1.2447697685021 0.473684210526316 9.3 9 3 alopecia 3.01455517020392e-05 0.000517152136957397 1.2447697685021 0.473684210526316 9.3 9 3 abnormal retinal outer nuclear layer morphology 0.00719118374458003 0.0433125171056727 1.2447697685021 0.473684210526316 9.3 9 3 kyphoscoliosis 0.0517993923678061 0.187404614861096 1.2447697685021 0.473684210526316 9.3 9 3 abnormal triglyceride level 0.0517993923678061 0.187404614861096 1.2447697685021 0.473684210526316 9.3 9 3 irregular coat pigmentation 0.0517993923678061 0.187404614861096 1.2447697685021 0.473684210526316 9.3 9 3 flaky skin 0.0517993923678061 0.187404614861096 1.2447697685021 0.473684210526316 9.3 9 3 abnormal stationary movement 0.0517993923678061 0.187404614861096 1.2447697685021 0.473684210526316 9.3 9 3 abnormal neural crest cell migration 0.0517993923678061 0.187404614861096 1.2447697685021 0.473684210526316 9.3 9 3 increased susceptibility to ischemic brain injury 0.0517993923678061 0.187404614861096 1.2447697685021 0.473684210526316 9.3 9 3 abnormal optic vesicle formation 0.0517993923678061 0.187404614861096 1.2447697685021 0.473684210526316 9.3 9 3 osteoarthritis 0.0517993923678061 0.187404614861096 1.2447697685021 0.473684210526316 9.3 9 3 increased left ventricle weight 0.0517993923678061 0.187404614861096 1.2447697685021 0.473684210526316 9.3 9 3 abnormal blastocyst morphology 0.0517993923678061 0.187404614861096 1.2447697685021 0.473684210526316 9.3 9 3 absent amnion 0.0517993923678061 0.187404614861096 1.2447697685021 0.473684210526316 9.3 9 3 decreased circulating magnesium level 0.0517993923678061 0.187404614861096 1.2447697685021 0.473684210526316 9.3 9 3 shortened RR interval 0.0517993923678061 0.187404614861096 1.2447697685021 0.473684210526316 9.3 9 3 increased circulating calcium level 0.00141824168658616 0.0128520079977525 1.24225508210109 0.472727272727273 9.3 9 3 abnormal joint morphology 0.00141824168658616 0.0128520079977525 1.24225508210109 0.472727272727273 9.3 9 3 abnormal platelet physiology 0.00141824168658616 0.0128520079977525 1.24225508210109 0.472727272727273 9.3 9 3 decreased hematocrit 3.01052708760403e-07 9.41973098165413e-06 1.24192782839137 0.472602739726027 9.3 9 3 heart right ventricle hypertrophy 0.0092272232528082 0.0523437122950066 1.24092788650055 0.472222222222222 9.3 9 3 abnormal limb bone morphology 0.0092272232528082 0.0523437122950066 1.24092788650055 0.472222222222222 9.3 9 3 abnormal pharyngeal arch morphology 0.0092272232528082 0.0523437122950066 1.24092788650055 0.472222222222222 9.3 9 3 abnormal retinal blood vessel morphology 0.0092272232528082 0.0523437122950066 1.24092788650055 0.472222222222222 9.3 9 3 abnormal placenta development 0.00180593141573167 0.015587034136472 1.23955060804717 0.471698113207547 9.3 9 3 abnormal endoderm development 0.0118537763729699 0.0645920454058326 1.23663401838117 0.470588235294118 9.3 9 3 impaired synaptic plasticity 0.0118537763729699 0.0645920454058326 1.23663401838117 0.470588235294118 9.3 9 3 abnormal bone remodeling 0.0118537763729699 0.0645920454058326 1.23663401838117 0.470588235294118 9.3 9 3 abnormal skin physiology 0.0118537763729699 0.0645920454058326 1.23663401838117 0.470588235294118 9.3 9 3 abnormal vagus nerve morphology 0.0680323262680734 0.22208715431999 1.23663401838117 0.470588235294118 9.3 9 3 abnormal dorsal-ventral axis patterning 0.0680323262680734 0.22208715431999 1.23663401838117 0.470588235294118 9.3 9 3 abnormal ectoplacental cone morphology 0.0680323262680734 0.22208715431999 1.23663401838117 0.470588235294118 9.3 9 3 abnormal tarsal bone morphology 0.0680323262680734 0.22208715431999 1.23663401838117 0.470588235294118 9.3 9 3 increased brain size 0.0680323262680734 0.22208715431999 1.23663401838117 0.470588235294118 9.3 9 3 increased circulating magnesium level 0.0680323262680734 0.22208715431999 1.23663401838117 0.470588235294118 9.3 9 3 delayed heart development 0.0680323262680734 0.22208715431999 1.23663401838117 0.470588235294118 9.3 9 3 abnormal cued conditioning behavior 0.00230075715267924 0.0185852423682732 1.23663401838117 0.470588235294118 9.3 9 3 decreased grip strength 5.99253163055126e-10 3.50739351317559e-08 1.23592817704648 0.470319634703196 9.3 9 3 ataxia 2.73077907172895e-09 1.38827620119461e-07 1.23586877455792 0.47029702970297 9.3 9 3 increased fluid intake 0.00293274575628003 0.022072941233808 1.23347933976285 0.469387755102041 9.3 9 3 increased circulating triglyceride level 5.22813740345525e-07 1.55748404683772e-05 1.23236976314538 0.468965517241379 9.3 9 3 decreased circulating HDL cholesterol level 2.41449353706383e-06 6.03623384265958e-05 1.23180341674687 0.46875 9.3 9 3 decreased circulating LDL cholesterol level 0.000753222658491095 0.00763194037880489 1.23180341674687 0.46875 9.3 9 3 neonatal lethality 0.0152480344901858 0.0797675831636954 1.23180341674687 0.46875 9.3 9 3 abnormal embryonic hematopoiesis 0.0152480344901858 0.0797675831636954 1.23180341674687 0.46875 9.3 9 3 increased cellular sensitivity to gamma-irradiation 0.00374049718533791 0.0267370308865749 1.23005617785787 0.468085106382979 9.3 9 3 neuron degeneration 0.00374049718533791 0.0267370308865749 1.23005617785787 0.468085106382979 9.3 9 3 decreased bone trabecula number 0.00374049718533791 0.0267370308865749 1.23005617785787 0.468085106382979 9.3 9 3 abnormal renal glomerulus morphology 1.41593659818182e-05 0.000256155802761984 1.22954322699137 0.467889908256881 9.3 9 3 oxidative stress 8.4043026314547e-05 0.00125183849076309 1.22632873489466 0.466666666666667 9.3 9 3 irregular heartbeat 0.00477369335176044 0.0328480282503571 1.22632873489466 0.466666666666667 9.3 9 3 increased metastatic potential 0.0196430226992089 0.0943899634003083 1.22632873489466 0.466666666666667 9.3 9 3 abnormal brain vasculature morphology 0.0196430226992089 0.0943899634003083 1.22632873489466 0.466666666666667 9.3 9 3 interdigital webbing 0.0898166945344847 0.256508642542515 1.22632873489466 0.466666666666667 9.3 9 3 decreased salivation 0.0898166945344847 0.256508642542515 1.22632873489466 0.466666666666667 9.3 9 3 vagina atresia 0.0898166945344847 0.256508642542515 1.22632873489466 0.466666666666667 9.3 9 3 hyperpigmentation 0.0898166945344847 0.256508642542515 1.22632873489466 0.466666666666667 9.3 9 3 no suckling reflex 0.0898166945344847 0.256508642542515 1.22632873489466 0.466666666666667 9.3 9 3 audiogenic seizures 0.0898166945344847 0.256508642542515 1.22632873489466 0.466666666666667 9.3 9 3 abnormal cricoid cartilage morphology 0.0898166945344847 0.256508642542515 1.22632873489466 0.466666666666667 9.3 9 3 arthritis 0.0898166945344847 0.256508642542515 1.22632873489466 0.466666666666667 9.3 9 3 abnormal glial cell morphology 0.0898166945344847 0.256508642542515 1.22632873489466 0.466666666666667 9.3 9 3 abnormal dendritic cell morphology 0.0898166945344847 0.256508642542515 1.22632873489466 0.466666666666667 9.3 9 3 abnormal cerebral aqueduct morphology 0.0898166945344847 0.256508642542515 1.22632873489466 0.466666666666667 9.3 9 3 abnormal secondary palate development 0.0898166945344847 0.256508642542515 1.22632873489466 0.466666666666667 9.3 9 3 bicuspid aortic valve 0.0898166945344847 0.256508642542515 1.22632873489466 0.466666666666667 9.3 9 3 decreased B cell number 4.07744716278633e-09 1.95050958027519e-07 1.22462786286291 0.466019417475728 9.3 9 3 abnormal fertility/fecundity 0.000401252485293657 0.00467501431928792 1.22392887435671 0.465753424657534 9.3 9 3 abnormal organ of Corti morphology 0.00609636579169426 0.0390843038836069 1.22225455305116 0.465116279069767 9.3 9 3 decreased oxygen consumption 0.00609636579169426 0.0390843038836069 1.22225455305116 0.465116279069767 9.3 9 3 abnormal jaw morphology 0.0253464841213462 0.107044786505686 1.220071955635 0.464285714285714 9.3 9 3 increased bone resorption 0.0253464841213462 0.107044786505686 1.220071955635 0.464285714285714 9.3 9 3 hypoxia 0.0253464841213462 0.107044786505686 1.220071955635 0.464285714285714 9.3 9 3 prolonged QRS complex duration 0.0253464841213462 0.107044786505686 1.220071955635 0.464285714285714 9.3 9 3 cyanosis 2.01547718458965e-08 8.42604957422985e-07 1.21811671211635 0.463541666666667 9.3 9 3 liver fibrosis 0.00779116197591231 0.0461440843216235 1.21778289005219 0.463414634146341 9.3 9 3 abnormal cholesterol homeostasis 0.00779116197591231 0.0461440843216235 1.21778289005219 0.463414634146341 9.3 9 3 decreased birth weight 7.20699893958151e-05 0.00109313474769567 1.21710821809094 0.463157894736842 9.3 9 3 neonatal lethality, complete penetrance 8.06430961602067e-18 1.82363365180467e-15 1.21595565349048 0.462719298245614 9.3 9 3 increased blood urea nitrogen level 1.22622805148757e-06 3.33359811811512e-05 1.21424667839324 0.462068965517241 9.3 9 3 abnormal spermatogenesis 5.01571706669477e-08 1.91947633898511e-06 1.21395119331576 0.46195652173913 9.3 9 3 absent corpus luteum 0.00316879185330266 0.0234943956336523 1.21285259495077 0.461538461538462 9.3 9 3 abnormal hair growth 0.00316879185330266 0.0234943956336523 1.21285259495077 0.461538461538462 9.3 9 3 increased susceptibility to injury 0.00316879185330266 0.0234943956336523 1.21285259495077 0.461538461538462 9.3 9 3 increased susceptibility to otitis media 0.0327668297710276 0.132640340204119 1.21285259495077 0.461538461538462 9.3 9 3 short hair 0.119349840056862 0.319744455725842 1.21285259495077 0.461538461538462 9.3 9 3 abnormal renal/urinary system morphology 0.119349840056862 0.319744455725842 1.21285259495077 0.461538461538462 9.3 9 3 abnormal sympathetic ganglion morphology 0.119349840056862 0.319744455725842 1.21285259495077 0.461538461538462 9.3 9 3 tight skin 0.119349840056862 0.319744455725842 1.21285259495077 0.461538461538462 9.3 9 3 pup cannibalization 0.119349840056862 0.319744455725842 1.21285259495077 0.461538461538462 9.3 9 3 lymphoid hypoplasia 0.119349840056862 0.319744455725842 1.21285259495077 0.461538461538462 9.3 9 3 abnormal pulmonary alveolus epithelial cell morphology 0.119349840056862 0.319744455725842 1.21285259495077 0.461538461538462 9.3 9 3 abnormal coping response 0.119349840056862 0.319744455725842 1.21285259495077 0.461538461538462 9.3 9 3 abnormal telomere length 0.119349840056862 0.319744455725842 1.21285259495077 0.461538461538462 9.3 9 3 decreased endocochlear potential 0.119349840056862 0.319744455725842 1.21285259495077 0.461538461538462 9.3 9 3 small pituitary gland 0.119349840056862 0.319744455725842 1.21285259495077 0.461538461538462 9.3 9 3 increased circulating alanine transaminase level 0.000342456684814156 0.00411527054818943 1.21285259495077 0.461538461538462 9.3 9 3 small lens 0.00996493035222577 0.0560809145953882 1.21285259495077 0.461538461538462 9.3 9 3 impaired macrophage chemotaxis 0.00996493035222577 0.0560809145953882 1.21285259495077 0.461538461538462 9.3 9 3 decreased B-1 B cell number 0.00996493035222577 0.0560809145953882 1.21285259495077 0.461538461538462 9.3 9 3 abnormal hair follicle morphology 0.0013096786894159 0.0119334276187621 1.20964399020222 0.46031746031746 9.3 9 3 increased circulating cholesterol level 1.2467659938302e-07 4.30740334673975e-06 1.20940699098784 0.460227272727273 9.3 9 3 increased spleen weight 2.08834172021025e-05 0.000369733098151104 1.20927485868247 0.460176991150442 9.3 9 3 decreased heart rate 6.15721848932732e-05 0.000951309378397622 1.2088097529676 0.46 9.3 9 3 abnormal retinal pigmentation 0.000182756694424489 0.00244412514720922 1.20820565014253 0.459770114942529 9.3 9 3 abnormal brain morphology 4.54130722714047e-07 1.36102430451951e-05 1.20783043099652 0.459627329192547 9.3 9 3 abnormal branching of the mammary ductal tree 0.0127560533454743 0.0687555421383908 1.20738929497351 0.459459459459459 9.3 9 3 impaired skeletal muscle contractility 0.0127560533454743 0.0687555421383908 1.20738929497351 0.459459459459459 9.3 9 3 decreased circulating chloride level 0.0127560533454743 0.0687555421383908 1.20738929497351 0.459459459459459 9.3 9 3 abnormal respiratory electron transport chain 0.0127560533454743 0.0687555421383908 1.20738929497351 0.459459459459459 9.3 9 3 abnormal intestinal epithelium morphology 0.00513083614252073 0.0350149654445002 1.20443000748583 0.458333333333333 9.3 9 3 thymus atrophy 0.00513083614252073 0.0350149654445002 1.20443000748583 0.458333333333333 9.3 9 3 abnormal digestive system morphology 0.0424491861537961 0.160841356523332 1.20443000748583 0.458333333333333 9.3 9 3 decreased metastatic potential 0.0424491861537961 0.160841356523332 1.20443000748583 0.458333333333333 9.3 9 3 blindness 0.0424491861537961 0.160841356523332 1.20443000748583 0.458333333333333 9.3 9 3 decreased ovulation rate 0.0424491861537961 0.160841356523332 1.20443000748583 0.458333333333333 9.3 9 3 abnormal lipid level 0.000291071985071891 0.00358154465582683 1.20311080703952 0.457831325301205 9.3 9 3 abnormal colon morphology 0.00210505746767864 0.0171515375683959 1.20257418312915 0.457627118644068 9.3 9 3 decreased triglyceride level 0.016344106796239 0.0835986889857357 1.201301617856 0.457142857142857 9.3 9 3 decreased bone mineralization 0.016344106796239 0.0835986889857357 1.201301617856 0.457142857142857 9.3 9 3 abnormal allantois morphology 0.0065331663015828 0.0409351414992121 1.19966941457087 0.456521739130435 9.3 9 3 increased macrophage cell number 0.0026696515267822 0.0204331020703714 1.19866718448351 0.456140350877193 9.3 9 3 limb grasping 1.43483625633956e-07 4.82318268600628e-06 1.1984138735823 0.456043956043956 9.3 9 3 abnormal visceral yolk sac morphology 0.00046362082504734 0.0051831766395742 1.19750003045772 0.455696202531646 9.3 9 3 increased leukocyte cell number 2.80004583019068e-06 6.86218128334909e-05 1.1961235936411 0.455172413793103 9.3 9 3 decreased circulating calcium level 0.00338643859712302 0.0248122710172121 1.19447604048182 0.454545454545455 9.3 9 3 abnormal contextual conditioning behavior 0.00338643859712302 0.0248122710172121 1.19447604048182 0.454545454545455 9.3 9 3 abnormal epidermis stratum basale morphology 0.0209626297137608 0.0943899634003083 1.19447604048182 0.454545454545455 9.3 9 3 dilated heart atrium 0.0209626297137608 0.0943899634003083 1.19447604048182 0.454545454545455 9.3 9 3 increased cardiomyocyte apoptosis 0.0209626297137608 0.0943899634003083 1.19447604048182 0.454545454545455 9.3 9 3 decreased macrophage cell number 0.00832274633328155 0.0486179949097515 1.19447604048182 0.454545454545455 9.3 9 3 abnormal amino acid level 0.00832274633328155 0.0486179949097515 1.19447604048182 0.454545454545455 9.3 9 3 embryonic lethality, incomplete penetrance 0.00832274633328155 0.0486179949097515 1.19447604048182 0.454545454545455 9.3 9 3 abnormal enterocyte morphology 0.0551261169081624 0.192457846749549 1.19447604048182 0.454545454545455 9.3 9 3 abnormal tail movements 0.0551261169081624 0.192457846749549 1.19447604048182 0.454545454545455 9.3 9 3 abnormal lysosome physiology 0.0551261169081624 0.192457846749549 1.19447604048182 0.454545454545455 9.3 9 3 abnormal cochlear sensory epithelium morphology 0.0551261169081624 0.192457846749549 1.19447604048182 0.454545454545455 9.3 9 3 abnormal retinal layer morphology 0.0551261169081624 0.192457846749549 1.19447604048182 0.454545454545455 9.3 9 3 abnormal temporal bone morphology 0.0551261169081624 0.192457846749549 1.19447604048182 0.454545454545455 9.3 9 3 abnormal cerebral cortex pyramidal cell morphology 0.0551261169081624 0.192457846749549 1.19447604048182 0.454545454545455 9.3 9 3 abnormal stomach epithelium morphology 0.159931338569176 0.39002863204983 1.19447604048182 0.454545454545455 9.3 9 3 abnormal large intestine morphology 0.159931338569176 0.39002863204983 1.19447604048182 0.454545454545455 9.3 9 3 abnormal food preference 0.159931338569176 0.39002863204983 1.19447604048182 0.454545454545455 9.3 9 3 vasculitis 0.159931338569176 0.39002863204983 1.19447604048182 0.454545454545455 9.3 9 3 abnormal larynx morphology 0.159931338569176 0.39002863204983 1.19447604048182 0.454545454545455 9.3 9 3 patent ductus arteriosus 0.159931338569176 0.39002863204983 1.19447604048182 0.454545454545455 9.3 9 3 dilated renal glomerular capsule 0.159931338569176 0.39002863204983 1.19447604048182 0.454545454545455 9.3 9 3 enlarged placenta 0.159931338569176 0.39002863204983 1.19447604048182 0.454545454545455 9.3 9 3 increased glycogen level 0.159931338569176 0.39002863204983 1.19447604048182 0.454545454545455 9.3 9 3 increased circulating triiodothyronine level 0.159931338569176 0.39002863204983 1.19447604048182 0.454545454545455 9.3 9 3 abnormal platelet aggregation 0.159931338569176 0.39002863204983 1.19447604048182 0.454545454545455 9.3 9 3 increased number of Howell-Jolly bodies 0.159931338569176 0.39002863204983 1.19447604048182 0.454545454545455 9.3 9 3 increased subcutaneous adipose tissue amount 0.159931338569176 0.39002863204983 1.19447604048182 0.454545454545455 9.3 9 3 decreased embryonic cilium length 0.159931338569176 0.39002863204983 1.19447604048182 0.454545454545455 9.3 9 3 thin hypoglossal nerve 0.159931338569176 0.39002863204983 1.19447604048182 0.454545454545455 9.3 9 3 postnatal lethality, complete penetrance 4.98136704257375e-14 6.35443616328318e-12 1.19138154296761 0.453367875647668 9.3 9 3 increased heart weight 5.52936151484956e-06 0.000118571437656796 1.19103869935813 0.453237410071942 9.3 9 3 abnormal tooth morphology 0.00177074225789646 0.0154011236591519 1.19074330285531 0.453125 9.3 9 3 increased circulating bilirubin level 0.0042966763533614 0.0300646481828031 1.18996858372528 0.452830188679245 9.3 9 3 decreased leukocyte cell number 6.93544247122515e-06 0.000142577794604732 1.1892447585527 0.452554744525547 9.3 9 3 decreased percent body fat/body weight 0.000932063809597673 0.00891734125528542 1.18793096628739 0.452054794520548 9.3 9 3 postnatal lethality 8.72179572137944e-07 2.43769290527319e-05 1.18728040168373 0.451807228915663 9.3 9 3 abnormal cranial ganglia morphology 0.0269160726171045 0.113288884323261 1.18676974344645 0.451612903225806 9.3 9 3 absent mature ovarian follicles 0.0269160726171045 0.113288884323261 1.18676974344645 0.451612903225806 9.3 9 3 abnormal nose morphology 0.0269160726171045 0.113288884323261 1.18676974344645 0.451612903225806 9.3 9 3 abnormal podocyte morphology 0.0269160726171045 0.113288884323261 1.18676974344645 0.451612903225806 9.3 9 3 impaired hematopoiesis 0.00545287329914334 0.0362190182419735 1.18510760094862 0.450980392156863 9.3 9 3 abnormal response to novel object 0.00545287329914334 0.0362190182419735 1.18510760094862 0.450980392156863 9.3 9 3 decreased double-positive T cell number 0.000139686906857904 0.00193039544893909 1.182531280077 0.45 9.3 9 3 epidermal hyperplasia 0.00283384837057524 0.0215862916274094 1.182531280077 0.45 9.3 9 3 decreased circulating phosphate level 0.0135277028873055 0.0715960870897284 1.182531280077 0.45 9.3 9 3 abnormal female reproductive system morphology 0.0135277028873055 0.0715960870897284 1.182531280077 0.45 9.3 9 3 small gonad 0.071790090689735 0.22255416112574 1.182531280077 0.45 9.3 9 3 abnormal hearing physiology 0.071790090689735 0.22255416112574 1.182531280077 0.45 9.3 9 3 decreased skin tensile strength 0.071790090689735 0.22255416112574 1.182531280077 0.45 9.3 9 3 abnormal lens epithelium morphology 0.071790090689735 0.22255416112574 1.182531280077 0.45 9.3 9 3 abnormal heart right ventricle morphology 0.071790090689735 0.22255416112574 1.182531280077 0.45 9.3 9 3 decreased circulating VLDL cholesterol level 0.071790090689735 0.22255416112574 1.182531280077 0.45 9.3 9 3 increased sarcoma incidence 0.00692187275353169 0.042672016045626 1.17984980325143 0.448979591836735 9.3 9 3 increased rib number 0.000782658648138787 0.00780305966831757 1.17916224509102 0.448717948717949 9.3 9 3 abnormal cornea morphology 0.000782658648138787 0.00780305966831757 1.17916224509102 0.448717948717949 9.3 9 3 increased urine protein level 0.000782658648138787 0.00780305966831757 1.17916224509102 0.448717948717949 9.3 9 3 abnormal heart ventricle morphology 0.000782658648138787 0.00780305966831757 1.17916224509102 0.448717948717949 9.3 9 3 infertility 9.37350571107954e-05 0.00135168669311944 1.17884738200822 0.448598130841121 9.3 9 3 abnormal spleen morphology 7.83307799767486e-07 2.20167022816002e-05 1.17800050888896 0.448275862068966 9.3 9 3 abnormal spinal nerve morphology 0.0346023887897051 0.139729613822064 1.17800050888896 0.448275862068966 9.3 9 3 increased retinal apoptosis 0.0346023887897051 0.139729613822064 1.17800050888896 0.448275862068966 9.3 9 3 hypoactivity 4.43291120848383e-13 4.69228367281001e-11 1.17800050888896 0.448275862068966 9.3 9 3 maternal effect 0.00187376500953693 0.0157710255666151 1.17664803987761 0.447761194029851 9.3 9 3 abnormal retina morphology 6.73555044749029e-08 2.50069876688539e-06 1.17627450081733 0.447619047619048 9.3 9 3 increased grooming behavior 0.0172609477842934 0.0873583064362761 1.17561589247421 0.447368421052632 9.3 9 3 decreased bone mineral content 8.41333430735182e-08 3.05778562764774e-06 1.17495095135855 0.447115384615385 9.3 9 3 azoospermia 2.83445351272135e-06 6.91245403224938e-05 1.17344124228465 0.446540880503145 9.3 9 3 reduced fertility 1.2202570559897e-05 0.000229953744452604 1.17213332317784 0.446043165467626 9.3 9 3 decreased body length 1.22862921377529e-09 6.86789925677759e-08 1.17006339147927 0.445255474452555 9.3 9 3 impaired coordination 9.31223502221329e-12 7.85226597212053e-10 1.16961989166254 0.445086705202312 9.3 9 3 skin lesions 0.00298425484433596 0.0223258163166488 1.16793212847111 0.444444444444444 9.3 9 3 gliosis 0.00298425484433596 0.0223258163166488 1.16793212847111 0.444444444444444 9.3 9 3 increased circulating aspartate transaminase level 0.00298425484433596 0.0223258163166488 1.16793212847111 0.444444444444444 9.3 9 3 abnormal cochlea morphology 0.00574057452582008 0.0371733201433472 1.16793212847111 0.444444444444444 9.3 9 3 diluted coat color 0.00574057452582008 0.0371733201433472 1.16793212847111 0.444444444444444 9.3 9 3 abnormal neuronal precursor proliferation 0.00574057452582008 0.0371733201433472 1.16793212847111 0.444444444444444 9.3 9 3 abnormal heart valve morphology 0.0445432867547694 0.168391224623843 1.16793212847111 0.444444444444444 9.3 9 3 thick interventricular septum 0.0445432867547694 0.168391224623843 1.16793212847111 0.444444444444444 9.3 9 3 increased exploration in new environment 0.000824446568949673 0.00812202312975173 1.16793212847111 0.444444444444444 9.3 9 3 increased circulating corticosterone level 0.0111619887184984 0.0617696261118235 1.16793212847111 0.444444444444444 9.3 9 3 cardiomyopathy 0.0111619887184984 0.0617696261118235 1.16793212847111 0.444444444444444 9.3 9 3 lethality at weaning, complete penetrance 0.0111619887184984 0.0617696261118235 1.16793212847111 0.444444444444444 9.3 9 3 abnormal epidermis stratum granulosum morphology 0.0220376136309836 0.098153410139339 1.16793212847111 0.444444444444444 9.3 9 3 abnormal phrenic nerve morphology 0.0937989242022499 0.266200597778775 1.16793212847111 0.444444444444444 9.3 9 3 abnormal iron level 0.0937989242022499 0.266200597778775 1.16793212847111 0.444444444444444 9.3 9 3 eye inflammation 0.0937989242022499 0.266200597778775 1.16793212847111 0.444444444444444 9.3 9 3 abnormal thymus cortex morphology 0.0937989242022499 0.266200597778775 1.16793212847111 0.444444444444444 9.3 9 3 abnormal white adipose tissue morphology 0.0937989242022499 0.266200597778775 1.16793212847111 0.444444444444444 9.3 9 3 abnormal sperm axoneme morphology 0.0937989242022499 0.266200597778775 1.16793212847111 0.444444444444444 9.3 9 3 increased effector memory CD4-positive, alpha-beta T cell number 0.0937989242022499 0.266200597778775 1.16793212847111 0.444444444444444 9.3 9 3 increased circulating insulin level 3.72963184259114e-06 8.67052262471539e-05 1.16610723452037 0.44375 9.3 9 3 obese 0.00130271076628561 0.0118917175454512 1.16034815361091 0.441558441558442 9.3 9 3 abnormal direction of heart looping 0.0281538297196484 0.117800927548571 1.15934439223235 0.441176470588235 9.3 9 3 increased body length 0.00919301292015251 0.0523437122950066 1.1562528071864 0.44 9.3 9 3 testicular atrophy 0.00919301292015251 0.0523437122950066 1.1562528071864 0.44 9.3 9 3 abnormal nest building behavior 0.0574249383302566 0.199922371023811 1.1562528071864 0.44 9.3 9 3 increased pre-B cell number 0.0574249383302566 0.199922371023811 1.1562528071864 0.44 9.3 9 3 abnormal preimplantation embryo development 0.0574249383302566 0.199922371023811 1.1562528071864 0.44 9.3 9 3 decreased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 0.0574249383302566 0.199922371023811 1.1562528071864 0.44 9.3 9 3 female infertility 6.30018950589771e-09 2.98508978969915e-07 1.15585764218052 0.43984962406015 9.3 9 3 increased or absent threshold for auditory brainstem response 1.56194868792155e-09 8.53922496968098e-08 1.15479794363536 0.439446366782007 9.3 9 3 increased T cell proliferation 0.000203503245024672 0.00268548711935741 1.15428806154972 0.439252336448598 9.3 9 3 Leydig cell hyperplasia 0.0180171696875262 0.0905506638728025 1.15368905373366 0.439024390243902 9.3 9 3 improved glucose tolerance 6.76648023014183e-07 1.93466891637676e-05 1.15303503499571 0.438775510204082 9.3 9 3 seminiferous tubule degeneration 0.00205680243493948 0.0169413776718939 1.15193305821808 0.438356164383562 9.3 9 3 decreased lymphocyte cell number 6.08181460189413e-05 0.000942586530978919 1.14968318896375 0.4375 9.3 9 3 abnormal hair shaft morphology 0.0116338539597348 0.0636726330579545 1.14968318896375 0.4375 9.3 9 3 abnormal phalanx morphology 0.0116338539597348 0.0636726330579545 1.14968318896375 0.4375 9.3 9 3 increased circulating follicle stimulating hormone level 0.0359912133824857 0.143474588604059 1.14968318896375 0.4375 9.3 9 3 abnormal lymphatic vessel morphology 0.0359912133824857 0.143474588604059 1.14968318896375 0.4375 9.3 9 3 abnormal heart atrium morphology 0.0359912133824857 0.143474588604059 1.14968318896375 0.4375 9.3 9 3 abnormal tympanic ring morphology 0.123032580357148 0.326835267653261 1.14968318896375 0.4375 9.3 9 3 vasculature congestion 0.123032580357148 0.326835267653261 1.14968318896375 0.4375 9.3 9 3 paternal imprinting 0.123032580357148 0.326835267653261 1.14968318896375 0.4375 9.3 9 3 large intestinal inflammation 0.123032580357148 0.326835267653261 1.14968318896375 0.4375 9.3 9 3 abnormal level of surface class II molecules 0.123032580357148 0.326835267653261 1.14968318896375 0.4375 9.3 9 3 abnormal fertilization 0.123032580357148 0.326835267653261 1.14968318896375 0.4375 9.3 9 3 decreased circulating triiodothyronine level 0.123032580357148 0.326835267653261 1.14968318896375 0.4375 9.3 9 3 decreased creatinine clearance 0.123032580357148 0.326835267653261 1.14968318896375 0.4375 9.3 9 3 dilated respiratory conducting tubes 0.123032580357148 0.326835267653261 1.14968318896375 0.4375 9.3 9 3 decreased midbrain size 0.123032580357148 0.326835267653261 1.14968318896375 0.4375 9.3 9 3 decreased fibroblast apoptosis 0.123032580357148 0.326835267653261 1.14968318896375 0.4375 9.3 9 3 abnormal neuron differentiation 0.000169812071140286 0.00230194837581178 1.14968318896375 0.4375 9.3 9 3 abnormal trabecular bone morphology 0.000113445579546122 0.00160795372718507 1.14830301706823 0.436974789915966 9.3 9 3 abnormal iris morphology 0.0228987794363455 0.0994078775705226 1.14547189523128 0.435897435897436 9.3 9 3 acanthosis 0.0228987794363455 0.0994078775705226 1.14547189523128 0.435897435897436 9.3 9 3 increased hepatocyte apoptosis 0.0228987794363455 0.0994078775705226 1.14547189523128 0.435897435897436 9.3 9 3 abnormal response to injury 0.0228987794363455 0.0994078775705226 1.14547189523128 0.435897435897436 9.3 9 3 abnormal circulating hormone level 0.0228987794363455 0.0994078775705226 1.14547189523128 0.435897435897436 9.3 9 3 decreased trabecular bone volume 0.0228987794363455 0.0994078775705226 1.14547189523128 0.435897435897436 9.3 9 3 hyperkeratosis 0.00324427137948875 0.023840842116627 1.1425422995913 0.434782608695652 9.3 9 3 decreased T cell number 1.02697011262757e-05 0.000201053043127876 1.1425422995913 0.434782608695652 9.3 9 3 abnormal pulmonary artery morphology 0.0741530186438406 0.22255416112574 1.1425422995913 0.434782608695652 9.3 9 3 abnormal cranial nerve morphology 0.0741530186438406 0.22255416112574 1.1425422995913 0.434782608695652 9.3 9 3 decreased epididymis weight 0.0741530186438406 0.22255416112574 1.1425422995913 0.434782608695652 9.3 9 3 abnormal B cell morphology 0.0741530186438406 0.22255416112574 1.1425422995913 0.434782608695652 9.3 9 3 decreased compact bone thickness 0.0040727844205547 0.0288633938636177 1.13742643854836 0.432835820895522 9.3 9 3 no abnormal phenotype detected 5.51220304597577e-47 6.85580253843237e-44 1.1359570413804 0.432276657060519 9.3 9 3 abnormal motor capabilities/coordination/movement 8.17065554721068e-05 0.00122436781166787 1.13475223845772 0.431818181818182 9.3 9 3 increased T cell number 0.00116820161983071 0.0109039457010465 1.13475223845772 0.431818181818182 9.3 9 3 abnormal circadian rhythm 0.0186306687519643 0.0930404180742822 1.13475223845772 0.431818181818182 9.3 9 3 abnormal myelopoiesis 0.0186306687519643 0.0930404180742822 1.13475223845772 0.431818181818182 9.3 9 3 decreased circulating cholesterol level 4.01044786379695e-06 9.19445996423494e-05 1.13442587888382 0.431693989071038 9.3 9 3 increased inflammatory response 0.000774396450883925 0.00778307544070207 1.13412356685747 0.431578947368421 9.3 9 3 dermatitis 0.00782082233010146 0.0461549123277043 1.13269279700862 0.431034482758621 9.3 9 3 abnormal spermiogenesis 0.00782082233010146 0.0461549123277043 1.13269279700862 0.431034482758621 9.3 9 3 thrombocytosis 0.00782082233010146 0.0461549123277043 1.13269279700862 0.431034482758621 9.3 9 3 abnormal gait 3.27172189121124e-09 1.61156598106692e-07 1.13107990111644 0.43042071197411 9.3 9 3 abnormal response to infection 0.00220937892214983 0.0179017266086245 1.13097225098785 0.430379746835443 9.3 9 3 increased circulating serum albumin level 0.0370111219122053 0.147304265210577 1.12622026674 0.428571428571429 9.3 9 3 abnormal intestinal goblet cell morphology 0.0370111219122053 0.147304265210577 1.12622026674 0.428571428571429 9.3 9 3 increased circulating HDL cholesterol level 0.000530835068372204 0.00584270899369848 1.12622026674 0.428571428571429 9.3 9 3 abnormal B cell differentiation 0.00120543203448528 0.0111262047709912 1.12622026674 0.428571428571429 9.3 9 3 arrest of spermatogenesis 0.00182238608959827 0.0156047690116203 1.12622026674 0.428571428571429 9.3 9 3 abnormal nervous system electrophysiology 0.00182238608959827 0.0156047690116203 1.12622026674 0.428571428571429 9.3 9 3 increased food intake 0.00182238608959827 0.0156047690116203 1.12622026674 0.428571428571429 9.3 9 3 abnormal respiratory system physiology 0.0151678398643871 0.0795152827453382 1.12622026674 0.428571428571429 9.3 9 3 abnormal optic nerve morphology 0.0235741264797255 0.101630224641798 1.12622026674 0.428571428571429 9.3 9 3 abnormal ovulation 0.0589408887298368 0.204199806010402 1.12622026674 0.428571428571429 9.3 9 3 abnormal respiration 0.0589408887298368 0.204199806010402 1.12622026674 0.428571428571429 9.3 9 3 abnormal retinal inner nuclear layer morphology 0.0589408887298368 0.204199806010402 1.12622026674 0.428571428571429 9.3 9 3 increased triglyceride level 0.0589408887298368 0.204199806010402 1.12622026674 0.428571428571429 9.3 9 3 liver degeneration 0.095927435948073 0.266356803686917 1.12622026674 0.428571428571429 9.3 9 3 decreased cochlear outer hair cell number 0.095927435948073 0.266356803686917 1.12622026674 0.428571428571429 9.3 9 3 increased bone ossification 0.095927435948073 0.266356803686917 1.12622026674 0.428571428571429 9.3 9 3 abnormal interparietal bone morphology 0.162132423096968 0.39251036735154 1.12622026674 0.428571428571429 9.3 9 3 abnormal blood flow velocity 0.162132423096968 0.39251036735154 1.12622026674 0.428571428571429 9.3 9 3 increased aggression towards males 0.162132423096968 0.39251036735154 1.12622026674 0.428571428571429 9.3 9 3 abnormal pinna reflex 0.162132423096968 0.39251036735154 1.12622026674 0.428571428571429 9.3 9 3 absent otoliths 0.162132423096968 0.39251036735154 1.12622026674 0.428571428571429 9.3 9 3 abnormal decidualization 0.162132423096968 0.39251036735154 1.12622026674 0.428571428571429 9.3 9 3 lysosomal protein accumulation 0.162132423096968 0.39251036735154 1.12622026674 0.428571428571429 9.3 9 3 decreased cornea thickness 0.162132423096968 0.39251036735154 1.12622026674 0.428571428571429 9.3 9 3 decreased tongue size 0.162132423096968 0.39251036735154 1.12622026674 0.428571428571429 9.3 9 3 increased B cell number 0.000292549192655608 0.00358154465582683 1.12301166199145 0.427350427350427 9.3 9 3 decreased litter size 3.18778789879828e-08 1.28936949565215e-06 1.12221236543487 0.427046263345196 9.3 9 3 lung inflammation 0.000108009736987533 0.00154855458649272 1.12069957915794 0.426470588235294 9.3 9 3 abnormal posture 0.00283767532147251 0.0215862916274094 1.1168350978505 0.425 9.3 9 3 perinatal lethality 0.0298252273204186 0.124689500772338 1.1168350978505 0.425 9.3 9 3 belly spot 0.0470649066120724 0.176221815193737 1.11484430444969 0.424242424242424 9.3 9 3 myeloid hyperplasia 0.0470649066120724 0.176221815193737 1.11484430444969 0.424242424242424 9.3 9 3 syndactyly 0.0100774855863307 0.0566502720813507 1.11349461400847 0.423728813559322 9.3 9 3 circling 0.00233281388211177 0.0185852423682732 1.11297061654306 0.423529411764706 9.3 9 3 male infertility 5.19151673985109e-13 5.38079078765816e-11 1.11278622777292 0.423459244532803 9.3 9 3 hyperactivity 5.9099808671674e-10 3.50025652549498e-08 1.1120539740766 0.423180592991914 9.3 9 3 abnormal skin condition 0.0155254078546847 0.0810481679717275 1.11178154537154 0.423076923076923 9.3 9 3 small seminal vesicle 0.0755075512736912 0.22255416112574 1.11178154537154 0.423076923076923 9.3 9 3 no spontaneous movement 0.0755075512736912 0.22255416112574 1.11178154537154 0.423076923076923 9.3 9 3 decreased Peyer's patch number 0.0755075512736912 0.22255416112574 1.11178154537154 0.423076923076923 9.3 9 3 decreased insulin secretion 0.00191815417400063 0.0160383479254674 1.10953552204755 0.422222222222222 9.3 9 3 decreased osteoclast cell number 0.0240885503148816 0.103758041399598 1.10953552204755 0.422222222222222 9.3 9 3 cataract 0.000381851669918521 0.0044666670820908 1.1076050557195 0.421487603305785 9.3 9 3 abnormal circulating amino acid level 0.012624121181426 0.0683405907264354 1.10646201644631 0.421052631578947 9.3 9 3 abnormal nail morphology 0.124344038263663 0.327307719768109 1.10646201644631 0.421052631578947 9.3 9 3 small superior vagus ganglion 0.124344038263663 0.327307719768109 1.10646201644631 0.421052631578947 9.3 9 3 delayed sexual maturation 0.124344038263663 0.327307719768109 1.10646201644631 0.421052631578947 9.3 9 3 abnormal neurotransmitter level 0.124344038263663 0.327307719768109 1.10646201644631 0.421052631578947 9.3 9 3 abnormal metatarsal bone morphology 0.124344038263663 0.327307719768109 1.10646201644631 0.421052631578947 9.3 9 3 eyelids fail to open 0.124344038263663 0.327307719768109 1.10646201644631 0.421052631578947 9.3 9 3 decreased fertilization frequency 0.124344038263663 0.327307719768109 1.10646201644631 0.421052631578947 9.3 9 3 decreased liver glycogen level 0.124344038263663 0.327307719768109 1.10646201644631 0.421052631578947 9.3 9 3 right-sided stomach 0.124344038263663 0.327307719768109 1.10646201644631 0.421052631578947 9.3 9 3 abnormal suckling behavior 0.0023842277769613 0.0186209312250902 1.10489033744568 0.420454545454545 9.3 9 3 increased liver weight 0.0023842277769613 0.0186209312250902 1.10489033744568 0.420454545454545 9.3 9 3 abnormal enzyme/coenzyme activity 6.44415919458313e-05 0.000989496666452194 1.10470013425452 0.420382165605096 9.3 9 3 kidney inflammation 0.0194944386860741 0.0943899634003083 1.1036958614052 0.42 9.3 9 3 decreased respiratory quotient 0.0194944386860741 0.0943899634003083 1.1036958614052 0.42 9.3 9 3 increased body weight 2.31598921335839e-06 5.82829811001867e-05 1.10275734451625 0.419642857142857 9.3 9 3 decreased double-negative T cell number 0.0598550045041321 0.207078336166938 1.10200047605742 0.419354838709677 9.3 9 3 decreased neutrophil cell number 0.000585005208798827 0.0063684921526787 1.10055142875162 0.418803418803419 9.3 9 3 abnormal homeostasis 0.0303382428320676 0.126206965477969 1.10002909774604 0.418604651162791 9.3 9 3 abnormal double-strand DNA break repair 0.0303382428320676 0.126206965477969 1.10002909774604 0.418604651162791 9.3 9 3 increased thermal nociceptive threshold 0.00242916250044559 0.0189421370528477 1.09734282400307 0.417582417582418 9.3 9 3 weight loss 3.71986891987503e-05 0.00061077055697618 1.0961877262936 0.417142857142857 9.3 9 3 abnormal foregut morphology 0.0967986132795871 0.266356803686917 1.09493637044166 0.416666666666667 9.3 9 3 increased stereotypic behavior 0.0967986132795871 0.266356803686917 1.09493637044166 0.416666666666667 9.3 9 3 abnormal startle reflex 0.0967986132795871 0.266356803686917 1.09493637044166 0.416666666666667 9.3 9 3 hemolytic anemia 0.0967986132795871 0.266356803686917 1.09493637044166 0.416666666666667 9.3 9 3 abnormal sensory capabilities/reflexes/nociception 0.0967986132795871 0.266356803686917 1.09493637044166 0.416666666666667 9.3 9 3 abnormal retinal ganglion layer morphology 0.0967986132795871 0.266356803686917 1.09493637044166 0.416666666666667 9.3 9 3 increased circulating total protein level 0.0967986132795871 0.266356803686917 1.09493637044166 0.416666666666667 9.3 9 3 decreased digestive secretion 0.214877349874178 0.462985148707923 1.09493637044166 0.416666666666667 9.3 9 3 amyloidosis 0.214877349874178 0.462985148707923 1.09493637044166 0.416666666666667 9.3 9 3 abnormal enteric nervous system morphology 0.214877349874178 0.462985148707923 1.09493637044166 0.416666666666667 9.3 9 3 impaired embryo implantation 0.214877349874178 0.462985148707923 1.09493637044166 0.416666666666667 9.3 9 3 myocarditis 0.214877349874178 0.462985148707923 1.09493637044166 0.416666666666667 9.3 9 3 abnormal respiratory function 0.214877349874178 0.462985148707923 1.09493637044166 0.416666666666667 9.3 9 3 abnormal alisphenoid bone morphology 0.214877349874178 0.462985148707923 1.09493637044166 0.416666666666667 9.3 9 3 absent ovary 0.214877349874178 0.462985148707923 1.09493637044166 0.416666666666667 9.3 9 3 delayed somite formation 0.214877349874178 0.462985148707923 1.09493637044166 0.416666666666667 9.3 9 3 decreased cochlear nerve compound action potential 0.214877349874178 0.462985148707923 1.09493637044166 0.416666666666667 9.3 9 3 abnormal palatine bone morphology 0.214877349874178 0.462985148707923 1.09493637044166 0.416666666666667 9.3 9 3 abnormal fatty acid level 0.214877349874178 0.462985148707923 1.09493637044166 0.416666666666667 9.3 9 3 abnormal somatic nervous system physiology 0.214877349874178 0.462985148707923 1.09493637044166 0.416666666666667 9.3 9 3 decreased keratinocyte proliferation 0.214877349874178 0.462985148707923 1.09493637044166 0.416666666666667 9.3 9 3 abnormal colon goblet cell morphology 0.214877349874178 0.462985148707923 1.09493637044166 0.416666666666667 9.3 9 3 abnormal coat/ hair morphology 0.0197733789780105 0.0943899634003083 1.09080453508151 0.415094339622642 9.3 9 3 abnormal pancreatic islet morphology 0.0197733789780105 0.0943899634003083 1.09080453508151 0.415094339622642 9.3 9 3 abnormal response/metabolism to endogenous compounds 0.00456051656744796 0.0314681968419606 1.08959521741512 0.414634146341463 9.3 9 3 thick ventricular wall 0.0381892681437176 0.151750486433702 1.08959521741512 0.414634146341463 9.3 9 3 abnormal lens morphology 0.000498238281083219 0.00553289162586833 1.0880930181264 0.4140625 9.3 9 3 cochlear ganglion degeneration 0.0160146850764786 0.0835147361168567 1.08738508512827 0.413793103448276 9.3 9 3 abnormal middle ear morphology 0.0761210063346354 0.22255416112574 1.08738508512827 0.413793103448276 9.3 9 3 focal hair loss 0.0761210063346354 0.22255416112574 1.08738508512827 0.413793103448276 9.3 9 3 polychromatophilia 0.0761210063346354 0.22255416112574 1.08738508512827 0.413793103448276 9.3 9 3 abnormal immune system morphology 0.0306793892182797 0.12711149561178 1.08541518461174 0.41304347826087 9.3 9 3 abnormal lymphocyte physiology 0.0306793892182797 0.12711149561178 1.08541518461174 0.41304347826087 9.3 9 3 seizures 0.00111920308054582 0.0104662318152546 1.08341072443702 0.412280701754386 9.3 9 3 abnormal brown adipose tissue morphology 0.060302660436769 0.208337316439532 1.08205476608353 0.411764705882353 9.3 9 3 decreased osteoblast cell number 0.060302660436769 0.208337316439532 1.08205476608353 0.411764705882353 9.3 9 3 abnormal glutamate-mediated receptor currents 0.161532758219499 0.39251036735154 1.08205476608353 0.411764705882353 9.3 9 3 decreased vasoconstriction 0.161532758219499 0.39251036735154 1.08205476608353 0.411764705882353 9.3 9 3 abnormal duodenum morphology 0.161532758219499 0.39251036735154 1.08205476608353 0.411764705882353 9.3 9 3 abnormal involuntary movement 0.161532758219499 0.39251036735154 1.08205476608353 0.411764705882353 9.3 9 3 abnormal ductus venosus valve morphology 0.161532758219499 0.39251036735154 1.08205476608353 0.411764705882353 9.3 9 3 cardiac fibrosis 0.0046170713973675 0.0318143077588689 1.08205476608353 0.411764705882353 9.3 9 3 increased lung adenocarcinoma incidence 0.0247192936131317 0.104751691418509 1.08205476608353 0.411764705882353 9.3 9 3 abnormal cervical vertebrae morphology 0.0247192936131317 0.104751691418509 1.08205476608353 0.411764705882353 9.3 9 3 abnormal spatial learning 0.000128434357285201 0.00179988993660247 1.08015808814122 0.411042944785276 9.3 9 3 increased anxiety-related response 0.000420452779369678 0.00487588013371597 1.0776064422764 0.410071942446043 9.3 9 3 spleen hypoplasia 0.00207131085568918 0.0170326801769482 1.07616603266266 0.40952380952381 9.3 9 3 impaired swimming 0.0131079692043647 0.0705759164412495 1.07502843643363 0.409090909090909 9.3 9 3 increased body size 0.124174502975703 0.327307719768109 1.07502843643363 0.409090909090909 9.3 9 3 intestinal inflammation 0.124174502975703 0.327307719768109 1.07502843643363 0.409090909090909 9.3 9 3 abnormal oogenesis 0.124174502975703 0.327307719768109 1.07502843643363 0.409090909090909 9.3 9 3 parakeratosis 0.124174502975703 0.327307719768109 1.07502843643363 0.409090909090909 9.3 9 3 decreased circulating estradiol level 0.124174502975703 0.327307719768109 1.07502843643363 0.409090909090909 9.3 9 3 abnormal sperm midpiece morphology 0.124174502975703 0.327307719768109 1.07502843643363 0.409090909090909 9.3 9 3 pulmonary vascular congestion 0.124174502975703 0.327307719768109 1.07502843643363 0.409090909090909 9.3 9 3 increased circulating creatine kinase level 0.124174502975703 0.327307719768109 1.07502843643363 0.409090909090909 9.3 9 3 abnormal trigeminal nerve morphology 0.09679548313045 0.266356803686917 1.07060445109852 0.407407407407407 9.3 9 3 decreased bone ossification 0.09679548313045 0.266356803686917 1.07060445109852 0.407407407407407 9.3 9 3 abnormal diaphragm morphology 0.0761828615873639 0.22255416112574 1.06756296118062 0.40625 9.3 9 3 abnormal depression-related behavior 0.0761828615873639 0.22255416112574 1.06756296118062 0.40625 9.3 9 3 abnormal coat appearance 0.0131820986253857 0.0707904476023716 1.06637281295188 0.405797101449275 9.3 9 3 increased brown adipose tissue amount 0.0603863983973582 0.208481840407257 1.06534349556486 0.405405405405405 9.3 9 3 decreased food intake 0.00870872080490083 0.0500406216856808 1.06444447151797 0.40506329113924 9.3 9 3 abnormal spleen white pulp morphology 0.0481275644752322 0.179351785216689 1.06365247414333 0.404761904761905 9.3 9 3 hepatic necrosis 0.0385245791637659 0.152595367308706 1.06232124451361 0.404255319148936 9.3 9 3 abnormal T-helper 1 physiology 0.0385245791637659 0.152595367308706 1.06232124451361 0.404255319148936 9.3 9 3 polyuria 0.0107385250745038 0.0597338208257366 1.05796449299818 0.402597402597403 9.3 9 3 reduced long term potentiation 0.00258889462551207 0.0198455327610517 1.05583150006875 0.401785714285714 9.3 9 3 abnormal social investigation 0.0107460843495546 0.0597338208257366 1.051138915624 0.4 9.3 9 3 thick epidermis 0.0163050179590977 0.0835986889857357 1.051138915624 0.4 9.3 9 3 abnormal learning/memory/conditioning 0.0309155597367343 0.12711149561178 1.051138915624 0.4 9.3 9 3 abnormal T-helper 2 physiology 0.0309155597367343 0.12711149561178 1.051138915624 0.4 9.3 9 3 increased circulating chloride level 0.0384620451375956 0.15259064956901 1.051138915624 0.4 9.3 9 3 decreased oocyte number 0.0384620451375956 0.15259064956901 1.051138915624 0.4 9.3 9 3 altered response to myocardial infarction 0.0480134438333881 0.179060631987336 1.051138915624 0.4 9.3 9 3 abnormal ectoderm development 0.0480134438333881 0.179060631987336 1.051138915624 0.4 9.3 9 3 decreased circulating thyroxine level 0.0758303527864785 0.22255416112574 1.051138915624 0.4 9.3 9 3 abnormal heart tube morphology 0.0961737412008067 0.266356803686917 1.051138915624 0.4 9.3 9 3 delayed eyelid opening 0.0961737412008067 0.266356803686917 1.051138915624 0.4 9.3 9 3 enhanced paired-pulse facilitation 0.0961737412008067 0.266356803686917 1.051138915624 0.4 9.3 9 3 abnormal cochlear outer hair cell morphology 0.123047729912474 0.326835267653261 1.051138915624 0.4 9.3 9 3 abnormal energy expenditure 0.123047729912474 0.326835267653261 1.051138915624 0.4 9.3 9 3 abnormal hair texture 0.159380003312949 0.39002863204983 1.051138915624 0.4 9.3 9 3 abnormal trachea morphology 0.159380003312949 0.39002863204983 1.051138915624 0.4 9.3 9 3 decreased paired-pulse facilitation 0.159380003312949 0.39002863204983 1.051138915624 0.4 9.3 9 3 decreased myocardial infarction size 0.159380003312949 0.39002863204983 1.051138915624 0.4 9.3 9 3 abnormal hyoid bone morphology 0.159380003312949 0.39002863204983 1.051138915624 0.4 9.3 9 3 absent placental labyrinth 0.159380003312949 0.39002863204983 1.051138915624 0.4 9.3 9 3 dilated vasculature 0.159380003312949 0.39002863204983 1.051138915624 0.4 9.3 9 3 abnormal neuron proliferation 0.159380003312949 0.39002863204983 1.051138915624 0.4 9.3 9 3 abnormal heart electrocardiography waveform feature 0.159380003312949 0.39002863204983 1.051138915624 0.4 9.3 9 3 abnormal epidermis stratum spinosum morphology 0.21034290880529 0.462985148707923 1.051138915624 0.4 9.3 9 3 abnormal pup retrieval 0.21034290880529 0.462985148707923 1.051138915624 0.4 9.3 9 3 abnormal bronchus morphology 0.21034290880529 0.462985148707923 1.051138915624 0.4 9.3 9 3 abnormal lymph node B cell domain morphology 0.21034290880529 0.462985148707923 1.051138915624 0.4 9.3 9 3 altered righting response 0.21034290880529 0.462985148707923 1.051138915624 0.4 9.3 9 3 increased alcohol consumption 0.21034290880529 0.462985148707923 1.051138915624 0.4 9.3 9 3 decreased aggression towards males 0.21034290880529 0.462985148707923 1.051138915624 0.4 9.3 9 3 abnormal zygomatic bone morphology 0.21034290880529 0.462985148707923 1.051138915624 0.4 9.3 9 3 abnormal Muller cell morphology 0.21034290880529 0.462985148707923 1.051138915624 0.4 9.3 9 3 decreased trabecular bone mass 0.21034290880529 0.462985148707923 1.051138915624 0.4 9.3 9 3 abnormal branching involved in lung morphogenesis 0.21034290880529 0.462985148707923 1.051138915624 0.4 9.3 9 3 decreased brown adipose tissue mass 0.21034290880529 0.462985148707923 1.051138915624 0.4 9.3 9 3 decreased anxiety-related response 0.00212479292667332 0.0172444450411089 1.04686599320276 0.398373983739837 9.3 9 3 decreased susceptibility to injury 0.020084202949894 0.0943899634003083 1.04340995300912 0.397058823529412 9.3 9 3 increased sensitivity to induced morbidity/mortality 0.000244384503769849 0.00308581955902283 1.04256984837706 0.396739130434783 9.3 9 3 abnormal enzyme/coenzyme level 0.0307955621605279 0.12711149561178 1.04207737324793 0.396551724137931 9.3 9 3 abnormal kidney physiology 0.0477367379562352 0.178295999498701 1.04018955191958 0.395833333333333 9.3 9 3 abnormal locomotor activation 0.00871058861905519 0.0500406216856808 1.03958793852923 0.395604395604396 9.3 9 3 increased total body fat amount 0.00173714042281973 0.0151353303039022 1.03937243522522 0.395522388059701 9.3 9 3 abnormal left-right axis patterning 0.0597590440111473 0.20689021847979 1.03891637009349 0.395348837209302 9.3 9 3 abnormal blood homeostasis 0.00385788792336158 0.027477998173577 1.03730814041842 0.394736842105263 9.3 9 3 increased bone marrow cell number 0.075164758340875 0.22255416112574 1.03730814041842 0.394736842105263 9.3 9 3 abnormal reproductive system physiology 0.075164758340875 0.22255416112574 1.03730814041842 0.394736842105263 9.3 9 3 dextrocardia 0.0951095323213035 0.266356803686917 1.03521256841757 0.393939393939394 9.3 9 3 decreased systemic arterial blood pressure 0.0951095323213035 0.266356803686917 1.03521256841757 0.393939393939394 9.3 9 3 abnormal T cell subpopulation ratio 0.0951095323213035 0.266356803686917 1.03521256841757 0.393939393939394 9.3 9 3 head tossing 0.0951095323213035 0.266356803686917 1.03521256841757 0.393939393939394 9.3 9 3 abnormal seminal vesicle morphology 0.0379999457276362 0.151118888884884 1.032368577845 0.392857142857143 9.3 9 3 absent corpus callosum 0.121289632448494 0.324417162059816 1.032368577845 0.392857142857143 9.3 9 3 enhanced coordination 0.121289632448494 0.324417162059816 1.032368577845 0.392857142857143 9.3 9 3 abnormal thrombosis 0.0473283364437014 0.176903436369207 1.03052834865098 0.392156862745098 9.3 9 3 increased lymphocyte cell number 0.0245212700156494 0.104089862054484 1.02828806963217 0.391304347826087 9.3 9 3 abnormal innervation pattern to muscle 0.156331171474758 0.385787489130417 1.02828806963217 0.391304347826087 9.3 9 3 increased sacral vertebrae number 0.0303440135575562 0.126206965477969 1.02650284728906 0.390625 9.3 9 3 scaly skin 0.0742620367136914 0.22255416112574 1.02550138109658 0.390243902439024 9.3 9 3 increased circulating glucose level 0.00207962121710095 0.017072797945672 1.02504681488156 0.390070921985816 9.3 9 3 polyphagia 0.0468134382328445 0.176221815193737 1.02194061241222 0.388888888888889 9.3 9 3 decreased platelet aggregation 0.0468134382328445 0.176221815193737 1.02194061241222 0.388888888888889 9.3 9 3 abnormal megakaryocyte differentiation 0.204636107139567 0.459830457551647 1.02194061241222 0.388888888888889 9.3 9 3 abnormal stomach glandular epithelium morphology 0.204636107139567 0.459830457551647 1.02194061241222 0.388888888888889 9.3 9 3 cortical renal glomerulopathies 0.204636107139567 0.459830457551647 1.02194061241222 0.388888888888889 9.3 9 3 absent spleen 0.204636107139567 0.459830457551647 1.02194061241222 0.388888888888889 9.3 9 3 acidosis 0.204636107139567 0.459830457551647 1.02194061241222 0.388888888888889 9.3 9 3 decreased activity of thyroid 0.204636107139567 0.459830457551647 1.02194061241222 0.388888888888889 9.3 9 3 decreased lactate dehydrogenase level 0.204636107139567 0.459830457551647 1.02194061241222 0.388888888888889 9.3 9 3 decreased pulmonary respiratory rate 0.204636107139567 0.459830457551647 1.02194061241222 0.388888888888889 9.3 9 3 abnormal pregnancy 0.204636107139567 0.459830457551647 1.02194061241222 0.388888888888889 9.3 9 3 decreased tumor latency 0.204636107139567 0.459830457551647 1.02194061241222 0.388888888888889 9.3 9 3 decreased fluid intake 0.204636107139567 0.459830457551647 1.02194061241222 0.388888888888889 9.3 9 3 decreased circulating creatinine level 0.0584158370424261 0.20294608190368 1.01896119371714 0.387755102040816 9.3 9 3 abnormal eyelid morphology 0.119111890693443 0.319744455725842 1.01723120866838 0.387096774193548 9.3 9 3 increased lung adenoma incidence 0.119111890693443 0.319744455725842 1.01723120866838 0.387096774193548 9.3 9 3 renal interstitial fibrosis 0.073179950638842 0.22255416112574 1.01530463440954 0.386363636363636 9.3 9 3 decreased sensitivity to induced morbidity/mortality 0.073179950638842 0.22255416112574 1.01530463440954 0.386363636363636 9.3 9 3 decreased startle reflex 0.0067393375213294 0.0419102552107672 1.01071049579231 0.384615384615385 9.3 9 3 small ovary 0.0155024498659232 0.0810133278182436 1.01071049579231 0.384615384615385 9.3 9 3 increased percent body fat/body weight 0.0575664156134649 0.200134813191466 1.01071049579231 0.384615384615385 9.3 9 3 decreased body temperature 0.0575664156134649 0.200134813191466 1.01071049579231 0.384615384615385 9.3 9 3 increased vascular permeability 0.0921171034481304 0.262475709996821 1.01071049579231 0.384615384615385 9.3 9 3 abnormal Schwann cell morphology 0.152760341561713 0.377349900332433 1.01071049579231 0.384615384615385 9.3 9 3 pulmonary edema 0.152760341561713 0.377349900332433 1.01071049579231 0.384615384615385 9.3 9 3 abnormal nerve conduction 0.152760341561713 0.377349900332433 1.01071049579231 0.384615384615385 9.3 9 3 absent trabeculae carneae 0.27458204351 0.491342409282857 1.01071049579231 0.384615384615385 9.3 9 3 small trigeminal ganglion 0.27458204351 0.491342409282857 1.01071049579231 0.384615384615385 9.3 9 3 excessive scratching 0.27458204351 0.491342409282857 1.01071049579231 0.384615384615385 9.3 9 3 abnormal digestion 0.27458204351 0.491342409282857 1.01071049579231 0.384615384615385 9.3 9 3 dystrophic cardiac calcinosis 0.27458204351 0.491342409282857 1.01071049579231 0.384615384615385 9.3 9 3 abnormal otolith morphology 0.27458204351 0.491342409282857 1.01071049579231 0.384615384615385 9.3 9 3 abnormal bile duct development 0.27458204351 0.491342409282857 1.01071049579231 0.384615384615385 9.3 9 3 tracheoesophageal fistula 0.27458204351 0.491342409282857 1.01071049579231 0.384615384615385 9.3 9 3 abnormal insulin secretion 0.27458204351 0.491342409282857 1.01071049579231 0.384615384615385 9.3 9 3 muscle fatigue 0.27458204351 0.491342409282857 1.01071049579231 0.384615384615385 9.3 9 3 increased renin activity 0.27458204351 0.491342409282857 1.01071049579231 0.384615384615385 9.3 9 3 increased prostaglandin level 0.27458204351 0.491342409282857 1.01071049579231 0.384615384615385 9.3 9 3 abnormal hair follicle inner root sheath morphology 0.27458204351 0.491342409282857 1.01071049579231 0.384615384615385 9.3 9 3 decreased cardiac stroke volume 0.27458204351 0.491342409282857 1.01071049579231 0.384615384615385 9.3 9 3 deafness 0.0124860587647319 0.0676668217369728 1.00866865640687 0.383838383838384 9.3 9 3 abnormal oocyte morphology 0.11665664348792 0.314732538694361 1.0047651399347 0.382352941176471 9.3 9 3 abnormal cytotoxic T cell physiology 0.090344788860436 0.257868803545995 1.00108468154666 0.380952380952381 9.3 9 3 small ears 0.19842773707595 0.448513399342505 1.00108468154666 0.380952380952381 9.3 9 3 increased incidence of induced tumors 0.19842773707595 0.448513399342505 1.00108468154666 0.380952380952381 9.3 9 3 abnormal circulating protein level 0.0706455804679671 0.22255416112574 0.998581969842798 0.38 9.3 9 3 abnormal calcium ion homeostasis 0.114021857688989 0.307790961477331 0.994320595860538 0.378378378378378 9.3 9 3 albuminuria 0.0884596154850103 0.25467973786917 0.992742309200442 0.377777777777778 9.3 9 3 abnormal epidermal layer morphology 0.0432514969901816 0.163756619121883 0.990203326312461 0.376811594202899 9.3 9 3 abnormal T cell differentiation 0.0176556773244978 0.0892652385054639 0.988695019646334 0.376237623762376 9.3 9 3 increased dopamine level 0.144869308157091 0.366408138323094 0.985442733397498 0.375 9.3 9 3 increased fatty acid level 0.144869308157091 0.366408138323094 0.985442733397498 0.375 9.3 9 3 abnormal auditory brainstem response waveform shape 0.144869308157091 0.366408138323094 0.985442733397498 0.375 9.3 9 3 abnormal vasodilation 0.192050706391861 0.434889514929226 0.985442733397498 0.375 9.3 9 3 abnormal primitive streak formation 0.192050706391861 0.434889514929226 0.985442733397498 0.375 9.3 9 3 increased body temperature 0.192050706391861 0.434889514929226 0.985442733397498 0.375 9.3 9 3 abnormal bone marrow cell number 0.262729105874176 0.491342409282857 0.985442733397498 0.375 9.3 9 3 abnormal mouth morphology 0.262729105874176 0.491342409282857 0.985442733397498 0.375 9.3 9 3 disorganized yolk sac vascular plexus 0.262729105874176 0.491342409282857 0.985442733397498 0.375 9.3 9 3 intraventricular hemorrhage 0.262729105874176 0.491342409282857 0.985442733397498 0.375 9.3 9 3 decreased cochlear coiling 0.262729105874176 0.491342409282857 0.985442733397498 0.375 9.3 9 3 impaired muscle relaxation 0.262729105874176 0.491342409282857 0.985442733397498 0.375 9.3 9 3 small epididymis 0.262729105874176 0.491342409282857 0.985442733397498 0.375 9.3 9 3 increased thymus weight 0.262729105874176 0.491342409282857 0.985442733397498 0.375 9.3 9 3 abnormal wound healing 0.262729105874176 0.491342409282857 0.985442733397498 0.375 9.3 9 3 decreased circulating prolactin level 0.262729105874176 0.491342409282857 0.985442733397498 0.375 9.3 9 3 impaired behavioral response to addictive substance 0.262729105874176 0.491342409282857 0.985442733397498 0.375 9.3 9 3 abnormal urinary bladder physiology 0.262729105874176 0.491342409282857 0.985442733397498 0.375 9.3 9 3 increased heart left ventricle size 0.262729105874176 0.491342409282857 0.985442733397498 0.375 9.3 9 3 teratozoospermia 0.0269805896127495 0.113464440679145 0.985442733397498 0.375 9.3 9 3 abnormal skin pigmentation 0.11127645027591 0.301752934208036 0.985442733397498 0.375 9.3 9 3 abnormal male reproductive system morphology 0.108469674697051 0.297484361421075 0.977803642440928 0.372093023255814 9.3 9 3 increased bone mineral density 0.0164117780893723 0.0835986889857357 0.976722001243537 0.371681415929204 9.3 9 3 abnormal action potential 0.0512708335725429 0.187404614861096 0.976057564507998 0.371428571428571 9.3 9 3 abnormal palate morphology 0.185680846521279 0.422253444178725 0.973276773725924 0.37037037037037 9.3 9 3 abnormal inner ear morphology 0.105637148728789 0.29003576982656 0.971160954652606 0.369565217391304 9.3 9 3 decreased threshold for auditory brainstem response 0.136688498975389 0.34642143780059 0.968154264390524 0.368421052631579 9.3 9 3 shiny skin 0.251473147317177 0.491342409282857 0.968154264390524 0.368421052631579 9.3 9 3 abnormal long term depression 0.251473147317177 0.491342409282857 0.968154264390524 0.368421052631579 9.3 9 3 decreased germ cell number 0.251473147317177 0.491342409282857 0.968154264390524 0.368421052631579 9.3 9 3 abnormal digestive system development 0.251473147317177 0.491342409282857 0.968154264390524 0.368421052631579 9.3 9 3 abnormal photoreceptor inner segment morphology 0.251473147317177 0.491342409282857 0.968154264390524 0.368421052631579 9.3 9 3 decreased urine osmolality 0.102804839350388 0.282415282036543 0.965331657205712 0.36734693877551 9.3 9 3 abnormal eye physiology 0.0783722086624649 0.228815573999861 0.963544005988664 0.366666666666667 9.3 9 3 abnormal response to new environment 0.17941417363158 0.422253444178725 0.963544005988664 0.366666666666667 9.3 9 3 increased neutrophil cell number 0.0112288189074858 0.0620704156274912 0.960523491863308 0.36551724137931 9.3 9 3 abnormal female meiosis 0.0999917635432624 0.274839239573332 0.96017497100269 0.365384615384615 9.3 9 3 decreased T cell proliferation 0.0109875838456397 0.0610080687857786 0.958809146008376 0.364864864864865 9.3 9 3 increased susceptibility to pharmacologically induced seizures 0.0355533320157935 0.143152443598799 0.958069324136456 0.364583333333333 9.3 9 3 increased sensitivity to xenobiotic induced morbidity/mortality 0.0271825674930869 0.114217291620023 0.955580832385452 0.363636363636364 9.3 9 3 abnormal photoreceptor outer segment morphology 0.128635231301743 0.335656205549099 0.955580832385452 0.363636363636364 9.3 9 3 cochlear hair cell degeneration 0.128635231301743 0.335656205549099 0.955580832385452 0.363636363636364 9.3 9 3 diarrhea 0.173303465777541 0.418333208269415 0.955580832385452 0.363636363636364 9.3 9 3 decreased sensitivity to xenobiotic induced morbidity/mortality 0.173303465777541 0.418333208269415 0.955580832385452 0.363636363636364 9.3 9 3 intestinal ulcer 0.240858156561805 0.491342409282857 0.955580832385452 0.363636363636364 9.3 9 3 increased coping response 0.240858156561805 0.491342409282857 0.955580832385452 0.363636363636364 9.3 9 3 aphakia 0.240858156561805 0.491342409282857 0.955580832385452 0.363636363636364 9.3 9 3 impaired humoral immune response 0.240858156561805 0.491342409282857 0.955580832385452 0.363636363636364 9.3 9 3 abnormal heart left ventricle morphology 0.0704171429393109 0.22255416112574 0.948944854382775 0.361111111111111 9.3 9 3 head tilt 0.167376958203983 0.404616310527121 0.948944854382775 0.361111111111111 9.3 9 3 increased double-negative T cell number 0.0917894636586589 0.261692023897896 0.947748202611801 0.360655737704918 9.3 9 3 abnormal male meiosis 0.0917894636586589 0.261692023897896 0.947748202611801 0.360655737704918 9.3 9 3 abnormal digestive system physiology 0.120894422471749 0.3237081548961 0.946025024061598 0.36 9.3 9 3 abnormal inner ear vestibule morphology 0.230864880661517 0.491342409282857 0.946025024061598 0.36 9.3 9 3 decreased acute inflammation 0.230864880661517 0.491342409282857 0.946025024061598 0.36 9.3 9 3 decreased eosinophil cell number 0.0891595840039815 0.256508642542515 0.944382619505935 0.359375 9.3 9 3 abnormal excitatory postsynaptic currents 0.0666335718695912 0.218668878661752 0.943329796072818 0.358974358974359 9.3 9 3 abnormal lens fiber morphology 0.161648480470653 0.39251036735154 0.943329796072818 0.358974358974359 9.3 9 3 impaired righting response 0.0489264014880001 0.182192251050001 0.940492713979366 0.357894736842105 9.3 9 3 dehydration 0.0840809974918413 0.242213643614308 0.938516888949998 0.357142857142857 9.3 9 3 abnormal eye development 0.113544903505892 0.306669866960811 0.938516888949998 0.357142857142857 9.3 9 3 myoclonus 0.221453743228382 0.472036149340703 0.938516888949998 0.357142857142857 9.3 9 3 abnormal spleen germinal center morphology 0.221453743228382 0.472036149340703 0.938516888949998 0.357142857142857 9.3 9 3 decreased circulating progesterone level 0.221453743228382 0.472036149340703 0.938516888949998 0.357142857142857 9.3 9 3 abnormal vasoconstriction 0.337054054850574 0.557091004279604 0.938516888949998 0.357142857142857 9.3 9 3 absent atrioventricular cushions 0.337054054850574 0.557091004279604 0.938516888949998 0.357142857142857 9.3 9 3 abnormal adrenal gland secretion 0.337054054850574 0.557091004279604 0.938516888949998 0.357142857142857 9.3 9 3 abnormal spleen periarteriolar lymphoid sheath morphology 0.337054054850574 0.557091004279604 0.938516888949998 0.357142857142857 9.3 9 3 decreased vascular permeability 0.337054054850574 0.557091004279604 0.938516888949998 0.357142857142857 9.3 9 3 absent olfactory bulb 0.337054054850574 0.557091004279604 0.938516888949998 0.357142857142857 9.3 9 3 decreased CNS synapse formation 0.337054054850574 0.557091004279604 0.938516888949998 0.357142857142857 9.3 9 3 abnormal iris pigmentation 0.337054054850574 0.557091004279604 0.938516888949998 0.357142857142857 9.3 9 3 premature hair loss 0.337054054850574 0.557091004279604 0.938516888949998 0.357142857142857 9.3 9 3 increased lung compliance 0.337054054850574 0.557091004279604 0.938516888949998 0.357142857142857 9.3 9 3 abnormal respiratory motile cilium physiology 0.337054054850574 0.557091004279604 0.938516888949998 0.357142857142857 9.3 9 3 abnormal eye electrophysiology 0.0334415921301614 0.135261724266303 0.933863086194874 0.355371900826446 9.3 9 3 abnormal retinal photoreceptor layer morphology 0.212580429247555 0.462985148707923 0.932461941279353 0.354838709677419 9.3 9 3 abnormal CD8-positive, alpha beta T cell morphology 0.212580429247555 0.462985148707923 0.932461941279353 0.354838709677419 9.3 9 3 abnormal T cell proliferation 0.212580429247555 0.462985148707923 0.932461941279353 0.354838709677419 9.3 9 3 abnormal cardiovascular system morphology 0.145678835457567 0.368268397561684 0.930695914875414 0.354166666666667 9.3 9 3 abnormal retinal photoreceptor morphology 0.20420173248097 0.459830457551647 0.92747551378588 0.352941176470588 9.3 9 3 decreased pancreatic beta cell number 0.20420173248097 0.459830457551647 0.92747551378588 0.352941176470588 9.3 9 3 abnormal urinary bladder morphology 0.317927113685817 0.52863883375232 0.92747551378588 0.352941176470588 9.3 9 3 distended urinary bladder 0.317927113685817 0.52863883375232 0.92747551378588 0.352941176470588 9.3 9 3 enlarged sebaceous gland 0.317927113685817 0.52863883375232 0.92747551378588 0.352941176470588 9.3 9 3 nephrocalcinosis 0.317927113685817 0.52863883375232 0.92747551378588 0.352941176470588 9.3 9 3 increased regulatory T cell number 0.317927113685817 0.52863883375232 0.92747551378588 0.352941176470588 9.3 9 3 coloboma 0.317927113685817 0.52863883375232 0.92747551378588 0.352941176470588 9.3 9 3 abnormal circulating chemokine level 0.317927113685817 0.52863883375232 0.92747551378588 0.352941176470588 9.3 9 3 increased hepatoma incidence 0.317927113685817 0.52863883375232 0.92747551378588 0.352941176470588 9.3 9 3 common atrium 0.317927113685817 0.52863883375232 0.92747551378588 0.352941176470588 9.3 9 3 abnormal survival 0.317927113685817 0.52863883375232 0.92747551378588 0.352941176470588 9.3 9 3 abnormal T cell activation 0.0939982018496589 0.266356803686917 0.923297696156214 0.351351351351351 9.3 9 3 increased white adipose tissue amount 0.196277637649605 0.444056956483303 0.923297696156214 0.351351351351351 9.3 9 3 increased trabecular bone volume 0.196277637649605 0.444056956483303 0.923297696156214 0.351351351351351 9.3 9 3 impaired natural killer cell mediated cytotoxicity 0.131454482017741 0.335656205549099 0.922051680371928 0.350877192982456 9.3 9 3 head bobbing 0.188771881344746 0.428244464062979 0.919746551170998 0.35 9.3 9 3 abnormal dopamine level 0.301061763319454 0.510782390537216 0.919746551170998 0.35 9.3 9 3 abnormal Peyer's patch T cell area morphology 0.301061763319454 0.510782390537216 0.919746551170998 0.35 9.3 9 3 abnormal male reproductive system physiology 0.301061763319454 0.510782390537216 0.919746551170998 0.35 9.3 9 3 abnormal thymocyte activation 0.301061763319454 0.510782390537216 0.919746551170998 0.35 9.3 9 3 abnormal postnatal subventricular zone morphology 0.301061763319454 0.510782390537216 0.919746551170998 0.35 9.3 9 3 abnormal circulating cytokine level 0.301061763319454 0.510782390537216 0.919746551170998 0.35 9.3 9 3 impaired macrophage phagocytosis 0.181651896561184 0.422253444178725 0.91669091478837 0.348837209302326 9.3 9 3 abnormal axon guidance 0.181651896561184 0.422253444178725 0.91669091478837 0.348837209302326 9.3 9 3 abnormal carpal bone morphology 0.285939215274897 0.505958363232834 0.914033839673041 0.347826086956522 9.3 9 3 bidirectional circling 0.285939215274897 0.505958363232834 0.914033839673041 0.347826086956522 9.3 9 3 failure of embryo implantation 0.285939215274897 0.505958363232834 0.914033839673041 0.347826086956522 9.3 9 3 pancreas inflammation 0.285939215274897 0.505958363232834 0.914033839673041 0.347826086956522 9.3 9 3 abnormal crista ampullaris morphology 0.285939215274897 0.505958363232834 0.914033839673041 0.347826086956522 9.3 9 3 abnormal hepatocyte physiology 0.285939215274897 0.505958363232834 0.914033839673041 0.347826086956522 9.3 9 3 decreased effector memory CD8-positive, alpha-beta T cell number 0.285939215274897 0.505958363232834 0.914033839673041 0.347826086956522 9.3 9 3 cochlear outer hair cell degeneration 0.111140443828051 0.301752934208036 0.912446975368053 0.347222222222222 9.3 9 3 organ of Corti degeneration 0.168455645889505 0.407026147790328 0.911702120694283 0.346938775510204 9.3 9 3 abnormal immune system physiology 0.0492707929253361 0.18333746806548 0.911269624432095 0.346774193548387 9.3 9 3 abnormal leukocyte migration 0.162329838828768 0.392797153780701 0.909639446213075 0.346153846153846 9.3 9 3 abnormal dendritic cell physiology 0.0667847489625205 0.219020518186249 0.908694856964671 0.345794392523364 9.3 9 3 decreased exploration in new environment 0.0974573170369525 0.268021090248114 0.907232992651664 0.345238095238095 9.3 9 3 abnormal circulating glucose level 0.259643775590532 0.491342409282857 0.906154237606894 0.344827586206897 9.3 9 3 aphagia 0.259643775590532 0.491342409282857 0.906154237606894 0.344827586206897 9.3 9 3 abnormal CD8-positive, alpha-beta T cell physiology 0.259643775590532 0.491342409282857 0.906154237606894 0.344827586206897 9.3 9 3 increased double-positive T cell number 0.259643775590532 0.491342409282857 0.906154237606894 0.344827586206897 9.3 9 3 abnormal CNS synaptic transmission 0.0829632040872569 0.239258076849544 0.902493008364038 0.343434343434343 9.3 9 3 impaired fertilization 0.130974291191092 0.335656205549099 0.900976213391998 0.342857142857143 9.3 9 3 enhanced long term potentiation 0.17854293233565 0.422253444178725 0.891591044502498 0.339285714285714 9.3 9 3 decreased circulating alanine transaminase level 0.153798145460835 0.379724949710995 0.888830700711469 0.338235294117647 9.3 9 3 decreased IgG level 0.105969947611847 0.2907890178538 0.875949096353331 0.333333333333333 9.3 9 3 cochlear inner hair cell degeneration 0.219059686140002 0.467534079170531 0.875949096353331 0.333333333333333 9.3 9 3 abnormal metabolism 0.23821092028758 0.491342409282857 0.875949096353331 0.333333333333333 9.3 9 3 abnormal estrous cycle 0.299758576570009 0.510782390537216 0.875949096353331 0.333333333333333 9.3 9 3 abnormal spleen marginal zone morphology 0.299758576570009 0.510782390537216 0.875949096353331 0.333333333333333 9.3 9 3 abnormal microglial cell physiology 0.299758576570009 0.510782390537216 0.875949096353331 0.333333333333333 9.3 9 3 cryptorchism 0.315481090546185 0.526330793248581 0.875949096353331 0.333333333333333 9.3 9 3 decreased susceptibility to pharmacologically induced seizures 0.315481090546185 0.526330793248581 0.875949096353331 0.333333333333333 9.3 9 3 curly vibrissae 0.332883469716416 0.552215825888352 0.875949096353331 0.333333333333333 9.3 9 3 abnormal cardiac muscle contractility 0.332883469716416 0.552215825888352 0.875949096353331 0.333333333333333 9.3 9 3 prolonged QT interval 0.332883469716416 0.552215825888352 0.875949096353331 0.333333333333333 9.3 9 3 abnormal apical ectodermal ridge morphology 0.400409627873217 0.646345846420913 0.875949096353331 0.333333333333333 9.3 9 3 increased airway responsiveness 0.400409627873217 0.646345846420913 0.875949096353331 0.333333333333333 9.3 9 3 abnormal trophectoderm morphology 0.400409627873217 0.646345846420913 0.875949096353331 0.333333333333333 9.3 9 3 abnormal systemic arterial blood pressure 0.272247525186876 0.491342409282857 0.875949096353331 0.333333333333333 9.3 9 3 abnormal vibrissa morphology 0.248761407197356 0.491342409282857 0.875949096353331 0.333333333333333 9.3 9 3 increased autoantibody level 0.260071744404969 0.491342409282857 0.875949096353331 0.333333333333333 9.3 9 3 trunk curl 0.352378776441206 0.581647117715661 0.875949096353331 0.333333333333333 9.3 9 3 abnormal associative learning 0.352378776441206 0.581647117715661 0.875949096353331 0.333333333333333 9.3 9 3 decreased vocalization 0.352378776441206 0.581647117715661 0.875949096353331 0.333333333333333 9.3 9 3 abnormal heart shape 0.374572616958942 0.614002889413752 0.875949096353331 0.333333333333333 9.3 9 3 right pulmonary isomerism 0.374572616958942 0.614002889413752 0.875949096353331 0.333333333333333 9.3 9 3 abnormal thymus medulla morphology 0.374572616958942 0.614002889413752 0.875949096353331 0.333333333333333 9.3 9 3 abnormal neutrophil morphology 0.374572616958942 0.614002889413752 0.875949096353331 0.333333333333333 9.3 9 3 impaired leukocyte tethering or rolling 0.374572616958942 0.614002889413752 0.875949096353331 0.333333333333333 9.3 9 3 decreased IgM level 0.139740680813933 0.353976520900875 0.866918693298142 0.329896907216495 9.3 9 3 abnormal excitatory postsynaptic potential 0.167030093082895 0.403974094840739 0.865266790300242 0.329268292682927 9.3 9 3 abnormal maternal nurturing 0.218050798022371 0.465580566592831 0.861589275101637 0.327868852459016 9.3 9 3 abnormal sleep pattern 0.26885079006662 0.491342409282857 0.856906724693476 0.326086956521739 9.3 9 3 abnormal intestinal mucosa morphology 0.281159101987232 0.500990878361919 0.855578187135812 0.325581395348837 9.3 9 3 abnormal chromosome morphology 0.308713071204765 0.515624500840179 0.85227479645189 0.324324324324324 9.3 9 3 decreased regulatory T cell number 0.324264267433118 0.538635970110105 0.850185887637057 0.323529411764706 9.3 9 3 increased susceptibility to weight gain 0.324264267433118 0.538635970110105 0.850185887637057 0.323529411764706 9.3 9 3 abnormal urine homeostasis 0.177132203571766 0.422253444178725 0.84857568709229 0.322916666666667 9.3 9 3 increased eosinophil cell number 0.243046559550371 0.491342409282857 0.84769267389032 0.32258064516129 9.3 9 3 increased susceptibility to parasitic infection 0.190409508724856 0.431762673612653 0.846750793141553 0.322222222222222 9.3 9 3 decreased inflammatory response 0.204972366361102 0.460378114061617 0.844665200054998 0.321428571428571 9.3 9 3 abnormal stria vascularis morphology 0.360020360328302 0.591317693177055 0.844665200054998 0.321428571428571 9.3 9 3 reddish skin 0.360020360328302 0.591317693177055 0.844665200054998 0.321428571428571 9.3 9 3 abnormal feces composition 0.380892217506957 0.623950866676691 0.840911132499198 0.32 9.3 9 3 abnormal stomach mucosa morphology 0.380892217506957 0.623950866676691 0.840911132499198 0.32 9.3 9 3 abnormal gametogenesis 0.314798671755614 0.525544762410799 0.836133228337271 0.318181818181818 9.3 9 3 abnormal facial nerve morphology 0.404421732384927 0.652187396633715 0.836133228337271 0.318181818181818 9.3 9 3 decreased cardiac output 0.404421732384927 0.652187396633715 0.836133228337271 0.318181818181818 9.3 9 3 decreased susceptibility to viral infection induced morbidity/mortality 0.404421732384927 0.652187396633715 0.836133228337271 0.318181818181818 9.3 9 3 arrested B cell differentiation 0.329928125244574 0.547861289416474 0.833219872140973 0.317073170731707 9.3 9 3 stereotypic behavior 0.431387756793603 0.675055720137006 0.829846512334735 0.315789473684211 9.3 9 3 increased malignant tumor incidence 0.431387756793603 0.675055720137006 0.829846512334735 0.315789473684211 9.3 9 3 decreased tumor incidence 0.431387756793603 0.675055720137006 0.829846512334735 0.315789473684211 9.3 9 3 abnormal response to novelty 0.431387756793603 0.675055720137006 0.829846512334735 0.315789473684211 9.3 9 3 decreased eye pigmentation 0.431387756793603 0.675055720137006 0.829846512334735 0.315789473684211 9.3 9 3 Leydig cell hypoplasia 0.431387756793603 0.675055720137006 0.829846512334735 0.315789473684211 9.3 9 3 increased CD4-positive, CD25-positive, alpha-beta regulatory T cell number 0.431387756793603 0.675055720137006 0.829846512334735 0.315789473684211 9.3 9 3 thin interventricular septum 0.431387756793603 0.675055720137006 0.829846512334735 0.315789473684211 9.3 9 3 impaired behavioral response to xenobiotic 0.364127166473921 0.597865562114771 0.825894862275998 0.314285714285714 9.3 9 3 abnormal humoral immune response 0.216390386592504 0.462985148707923 0.825894862275998 0.314285714285714 9.3 9 3 abnormal crypts of Lieberkuhn morphology 0.383646444017951 0.623979760758628 0.821202277831248 0.3125 9.3 9 3 abnormal extraembryonic endoderm formation 0.462991683327326 0.677758597574744 0.821202277831248 0.3125 9.3 9 3 abnormal meiosis 0.462991683327326 0.677758597574744 0.821202277831248 0.3125 9.3 9 3 white spotting 0.462991683327326 0.677758597574744 0.821202277831248 0.3125 9.3 9 3 decreased aggression towards mice 0.462991683327326 0.677758597574744 0.821202277831248 0.3125 9.3 9 3 abnormal amnion morphology 0.462991683327326 0.677758597574744 0.821202277831248 0.3125 9.3 9 3 decreased circulating growth hormone level 0.462991683327326 0.677758597574744 0.821202277831248 0.3125 9.3 9 3 abnormal NK cell physiology 0.308752841809627 0.515624500840179 0.818509811346555 0.311475409836066 9.3 9 3 abnormal microglial cell morphology 0.405189823460298 0.653002711925812 0.815538813846205 0.310344827586207 9.3 9 3 decreased granulocyte number 0.405189823460298 0.653002711925812 0.815538813846205 0.310344827586207 9.3 9 3 decreased IgA level 0.351235016598303 0.580336834133695 0.808568396633844 0.307692307692308 9.3 9 3 abnormal leukocyte cell number 0.42919349527099 0.675055720137006 0.808568396633844 0.307692307692308 9.3 9 3 abnormal ocular fundus morphology 0.42919349527099 0.675055720137006 0.808568396633844 0.307692307692308 9.3 9 3 abnormal tectorial membrane morphology 0.42919349527099 0.675055720137006 0.808568396633844 0.307692307692308 9.3 9 3 abnormal erythrocyte osmotic lysis 0.42919349527099 0.675055720137006 0.808568396633844 0.307692307692308 9.3 9 3 decreased monocyte cell number 0.32413969067581 0.538635970110105 0.808568396633844 0.307692307692308 9.3 9 3 abnormal leukocyte adhesion 0.384630826301053 0.623979760758628 0.808568396633844 0.307692307692308 9.3 9 3 abnormal cytokine secretion 0.230179563048134 0.490425407350949 0.802005341466362 0.305194805194805 9.3 9 3 abnormal cochlear ganglion morphology 0.456257833620565 0.677758597574744 0.799779609713911 0.304347826086957 9.3 9 3 increased susceptibility to age related obesity 0.456257833620565 0.677758597574744 0.799779609713911 0.304347826086957 9.3 9 3 abnormal lens development 0.456257833620565 0.677758597574744 0.799779609713911 0.304347826086957 9.3 9 3 absent vibrissae 0.426353373536595 0.672513644053444 0.79631736032121 0.303030303030303 9.3 9 3 increased susceptibility to weight loss 0.42330061981552 0.668122012557808 0.788354186717998 0.3 9.3 9 3 abnormal hair cycle 0.450374643556137 0.677758597574744 0.788354186717998 0.3 9.3 9 3 gastrointestinal hemorrhage 0.450374643556137 0.677758597574744 0.788354186717998 0.3 9.3 9 3 salivary gland inflammation 0.450374643556137 0.677758597574744 0.788354186717998 0.3 9.3 9 3 abnormal synaptic transmission 0.450374643556137 0.677758597574744 0.788354186717998 0.3 9.3 9 3 abnormal optic stalk morphology 0.48724175399681 0.694364859963944 0.788354186717998 0.3 9.3 9 3 nuclear cataracts 0.48724175399681 0.694364859963944 0.788354186717998 0.3 9.3 9 3 increased insulin secretion 0.445102382170607 0.677758597574744 0.781251896747566 0.297297297297297 9.3 9 3 decreased cytotoxic T cell cytolysis 0.46889050107971 0.677758597574744 0.772896261488234 0.294117647058824 9.3 9 3 abnormal heart rate 0.523435254011288 0.733088543640348 0.772896261488234 0.294117647058824 9.3 9 3 abnormal touch/ nociception 0.523435254011288 0.733088543640348 0.772896261488234 0.294117647058824 9.3 9 3 aminoaciduria 0.523435254011288 0.733088543640348 0.772896261488234 0.294117647058824 9.3 9 3 abnormal testis development 0.523435254011288 0.733088543640348 0.772896261488234 0.294117647058824 9.3 9 3 decreased growth hormone level 0.523435254011288 0.733088543640348 0.772896261488234 0.294117647058824 9.3 9 3 abnormal electroretinogram waveform feature 0.523435254011288 0.733088543640348 0.772896261488234 0.294117647058824 9.3 9 3 decreased body fat mass 0.523435254011288 0.733088543640348 0.772896261488234 0.294117647058824 9.3 9 3 decreased fatty acid level 0.507059042286979 0.720130955003632 0.766455459309165 0.291666666666667 9.3 9 3 abnormal cellular extravasation 0.507059042286979 0.720130955003632 0.766455459309165 0.291666666666667 9.3 9 3 abnormal inner cell mass apoptosis 0.507059042286979 0.720130955003632 0.766455459309165 0.291666666666667 9.3 9 3 increased susceptibility to bacterial infection induced morbidity/mortality 0.424061587292619 0.66911081407573 0.766455459309165 0.291666666666667 9.3 9 3 abnormal intestine physiology 0.495007551351282 0.705229830461807 0.762923406501288 0.290322580645161 9.3 9 3 increased circulating luteinizing hormone level 0.523893219401635 0.733088543640348 0.750813511159998 0.285714285714286 9.3 9 3 abnormal salivary gland morphology 0.541186945019051 0.75312029411742 0.750813511159998 0.285714285714286 9.3 9 3 abnormal anxiety-related response 0.541186945019051 0.75312029411742 0.750813511159998 0.285714285714286 9.3 9 3 increased vasoconstriction 0.541186945019051 0.75312029411742 0.750813511159998 0.285714285714286 9.3 9 3 hypoalgesia 0.541186945019051 0.75312029411742 0.750813511159998 0.285714285714286 9.3 9 3 dry skin 0.541186945019051 0.75312029411742 0.750813511159998 0.285714285714286 9.3 9 3 abnormal long term potentiation 0.538583636829542 0.750547224993549 0.739082050048123 0.28125 9.3 9 3 abnormal inflammatory response 0.528573136837701 0.73680340593095 0.729957580294443 0.277777777777778 9.3 9 3 abnormal retinal rod cell morphology 0.580690114416036 0.800036920304564 0.729957580294443 0.277777777777778 9.3 9 3 abnormal redox activity 0.580690114416036 0.800036920304564 0.729957580294443 0.277777777777778 9.3 9 3 increased susceptibility to autoimmune disorder 0.580690114416036 0.800036920304564 0.729957580294443 0.277777777777778 9.3 9 3 abnormal macrophage chemotaxis 0.580690114416036 0.800036920304564 0.729957580294443 0.277777777777778 9.3 9 3 increased systemic arterial blood pressure 0.549448026086453 0.760209459262434 0.726851377825105 0.276595744680851 9.3 9 3 decreased retinal photoreceptor cell number 0.569113560712619 0.784957018171689 0.724923390085516 0.275862068965517 9.3 9 3 increased susceptibility to induced arthritis 0.569113560712619 0.784957018171689 0.724923390085516 0.275862068965517 9.3 9 3 enlarged epididymis 0.569113560712619 0.784957018171689 0.724923390085516 0.275862068965517 9.3 9 3 abnormal channel response 0.592473899756847 0.808013097483437 0.716685624289089 0.272727272727273 9.3 9 3 abnormal female reproductive system physiology 0.592473899756847 0.808013097483437 0.716685624289089 0.272727272727273 9.3 9 3 abnormal retinal outer plexiform layer morphology 0.592473899756847 0.808013097483437 0.716685624289089 0.272727272727273 9.3 9 3 abnormal lymph node morphology 0.584221878231562 0.804679912569774 0.711708640787082 0.270833333333333 9.3 9 3 abnormal pancreatic beta cell physiology 0.591123042100996 0.808013097483437 0.710228997043241 0.27027027027027 9.3 9 3 abnormal CD4-positive, alpha-beta T cell physiology 0.604855692274042 0.808013097483437 0.703226739325914 0.267605633802817 9.3 9 3 arrested T cell differentiation 0.612291348769522 0.808013097483437 0.700759277082665 0.266666666666667 9.3 9 3 abnormal pain threshold 0.612291348769522 0.808013097483437 0.700759277082665 0.266666666666667 9.3 9 3 abnormal vision 0.620910599978884 0.808013097483437 0.69560663533941 0.264705882352941 9.3 9 3 increased susceptibility to viral infection induced morbidity/mortality 0.620910599978884 0.808013097483437 0.69560663533941 0.264705882352941 9.3 9 3 altered susceptibility to infection 0.634012384995477 0.823124116741257 0.691538760278946 0.263157894736842 9.3 9 3 abnormal behavioral response to xenobiotic 0.634012384995477 0.823124116741257 0.691538760278946 0.263157894736842 9.3 9 3 abnormal food intake 0.652613703116851 0.846610996872577 0.685525379754781 0.260869565217391 9.3 9 3 abnormal retinal cone cell morphology 0.640550158393181 0.831178152844569 0.685525379754781 0.260869565217391 9.3 9 3 blistering 0.640550158393181 0.831178152844569 0.685525379754781 0.260869565217391 9.3 9 3 waved hair 0.682935928661699 0.885185270033872 0.656961822264998 0.25 9.3 9 3 hypopigmentation 0.685047197095249 0.885683421400433 0.656961822264998 0.25 9.3 9 3 abnormal inhibitory postsynaptic currents 0.724467865823141 0.903176369883172 0.656961822264998 0.25 9.3 9 3 decreased susceptibility to induced arthritis 0.739817111388858 0.920147532289892 0.645436176260349 0.245614035087719 9.3 9 3 stomach inflammation 0.725739323361241 0.904220669602348 0.634307966324826 0.241379310344828 9.3 9 3 increased activated T cell number 0.766867364371551 0.949518451405791 0.597238020240908 0.227272727272727 9.3 9 3 autoimmune response 0.791528167093575 0.975992814180196 0.593384871723224 0.225806451612903 9.3 9 3 wrinkled skin 0.795678082481544 0.975992814180196 0.583966064235554 0.222222222222222 9.3 9 3 abnormal single cell response 0.795678082481544 0.975992814180196 0.583966064235554 0.222222222222222 9.3 9 3 abnormal serotonin level 0.819605193764007 0.994520936335594 0.574841594481874 0.21875 9.3 9 3 abnormal regulatory T cell physiology 0.80195547714332 0.977156134897873 0.571271149795651 0.217391304347826 9.3 9 3 increased susceptibility to fungal infection 0.80195547714332 0.977156134897873 0.571271149795651 0.217391304347826 9.3 9 3 small lymph nodes 0.832720813998076 1 0.547468185220832 0.208333333333333 9.3 9 3 impaired conditioned place preference behavior 0.859461064657604 1 0.525569457811999 0.2 9.3 9 3 abnormal reflex 0.903312135150174 1 0.51097030620611 0.194444444444444 9.3 9 3 abnormal body temperature homeostasis 0.893359591913366 1 0.508615604334192 0.193548387096774 9.3 9 3 decreased susceptibility to bacterial infection induced morbidity/mortality 0.893359591913366 1 0.508615604334192 0.193548387096774 9.3 9 3 hypertension 0.946335233124327 1 0.477790416192726 0.181818181818182 9.3 9 3 decreased susceptibility to parasitic infection 0.963361390847157 1 0.410601138915624 0.15625 9.3 9 3